bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in Aerobic Capacity and Running Speed Across Various Somatotype Structures and Body Fat Compositions among Professional Football Athletes in Indonesia
Authors: Dhoni Akbar Ghozali  , Muhammad Syauqi Ridhallah  , Syania Shabrina  , Ahmad Isnaini Shidqi Nurhani  , Yunia Hastami  , Dwi Rahayu  , Lukman Aryoseto  , Selfi Handayani  , Siti Munawaroh  , Nanang Wiyono  , Agus Sugeng Riyanto  , Enrico Ananda Budiono  , Annisa Aghnia Rahma  , Muhana Fawwazy Ilyas  
Published: July 2024

Highlights:1. This study emphasizes the significance of understanding professional football players' various somatotype structures and body fat compositions as an important contribution to the area of sports science.This study lays the groundwork for future research to better understand the intricate interactions between somatotype structures, body composition, and athletic performance.2. Since a one-size-fits-all approach may not be successful, this study advocates for tailored evaluations of training regimens to cater to athletes' unique requirements and skills, which may lead to higher overall performance.

Abstract
This study investigated the effects of somatotype structures and body fat composition on professional football athletes' aerobic capacities and running speed. This study used an analytical observational design with a cross-sectional approach. The subjects comprised 27 professional football athletes from Bhayangkara Football Club, located in Bekasi, Indonesia. This study measured several variables, i.e., players' age, playing position, somatotype structures assessed using the Somatotype Rating Form and Heath-Carter Somatochart, body fat composition measured using Brozek and Siri formulas, aerobic capacities determined by the maximum rate of oxygen (VO2 max) through the Yo-Yo Intermittent Recovery Test Level 2, and running speed over a 30 m distance. The data were presented as mean ± standard deviation (SD), frequency (n), and percentage. The Shapiro-Wilk was used to determine the normality of the data distribution. The statistical analyses were conducted using one-way analysis of variance (ANOVA) followed by the post-hoc least significant difference (LSD) test, the Kruskal-Wallis test followed by the post-hoc Mann-Whitney test, as well as the independent t-test, the Mann-Whitney test, and Pearson's or Spearman's correlation tests. A value of p<0.05 was considered statistically significant. The athletes exhibited a predominant somatotype structure of mesomorph-endomorph (88.9%). Notable associations were found between mesomorphy rating and running speed (r=-0.548; p=0.003), body fat composition and aerobic capacity (r=-0.448; p=0.019), as well as age and aerobic capacity (r=-0.515; p=0.006). Notably, differences in aerobic capacity were observed among various age groups (p=0.031). There were also differences in body fat composition (p=0.003) and running speed (p=0.036) between two distinct somatotype structures. These findings underscore the importance of considering individualized training and conditioning programs that account for athletes' unique body compositions and ages.
The Impact of Confucian Culture on Corporate Environmental Governance
Authors: Wu Xiancong , Hao Meng , Wu Di , Skolnik Richard 
Published: July 2024

Using A-share listed companies in Shanghai and Shenzhen from 2010 to 2019 and the density of Confucian temples and schools near sample company headquarters, this paper uses regression analysis to estimate the impact of Confucian culture on corporate environmental governance. Enterprise environmental capital investment as a percent of total assets is the dependent variable used as a proxy for environmental governance. The log of the number of the number of Confucian temples and Confucian academies within a 200-kilometer radius of the company's registered location plus one is the independent variable. This study finds that the environmental capital expenditures increase by 0.007% for every unit increase in the independent variable. Similar results are found when the radius is expanded to 300 kilometers. The greater the influence of Confucian culture is, the more inclined enterprises are to participate in corporate environmental governance. Additionally, environmental governance information disclosure can be a key influence path for this correlation. Further analysis finds that the relationship between Confucian culture and environmental governance is stronger with more experienced managers, a more developed institutional environment, and after 2015 following the People's Republic of China’s enactment of the Environmental Protection Law. This study expands the literature on the factors that influence Confucian culture on corporate environmental governance, enriches the empirical evidence of the influence of the informal system of corporate environmental governance on enterprise decision-making, and confirms the modern commercial value of Confucian culture.
Validasi Metode Analisis Kandungan Nitrogen Dioksida di Lingkungan Kerja menggunakan Metode Griess-Saltzman
Authors: Al Faruq Fauzan Mujahid , Purnomo Dwi 
Published: July 2024

Abstrak
Nitrogen dioksida merupakan adalah gas beracun yang dihasilkan terutama sebagai produk sampingan dari proses pembakaran seperti mesin mobil, pembangkit listrik, dan asap rokok. Gas NO2 dapat menyebabkan berbagai penyakit pernafasan akut. Karne NO2 termasuk polutan berbahaya, maka dibutuhkan pemantauan pada NO2 untuk membuat lingkungan lebih aman dan bersih. Dalam pemantauan konsentrasi NO2 di udara ambien terdapat suatu metode yang telah ditetapkan dalam SNI:7119-2:2017. Metode tersebut diperlukan diuji kembali agar sesuai dengan ketentuan dalam pengujian kadar NO2 di lingkungan kerja yang memiliki nilai ambang batas yang berbeda dengan udara ambien. Untuk mencapai hal tersebut harus dilakukan validasi metode sebagai pemenuhan syarat bahwa metode dapat diaplikasikan dalam analisa. Validasi metode tersebut dilakukan penentuan linearitas, batas deteksi dan batas kuantifikasi, uji presisi dan akurasi metode, ketahanan dan ketangguhan metode uji, dan estimasi ketidakpastian pengukuran. Hasil menunjukkan bahwa dari seluruh parameter uji telah memenuhi syarat keberterimaan.
Kata kunci: lingkungan kerja, metode griess-saltzman, nitrogen dioksida
Abstract
Nitrogen dioxide is a toxic gas produced mainly as a by-product of combustion processes such as automobile engines, power plants, and cigarette smoke. NO2 gas can cause various acute respiratory diseases. Since NO2 is a hazardous pollutant, it is necessary to monitor NO2 to make the environment safer and cleaner. In monitoring the concentration of NO2 in ambient air, there is a method that has been established in SNI: 7119-2: 2017. The method needs to be tested again so that it is in accordance with the provisions in testing NO2 levels in the work environment which has a different threshold value from ambient air. To achieve this, method validation must be carried out as a fulfillment of the requirement that the method can be applied in analysis. The validation of the method is carried out by determining linearity, detection limit and limit of quantification, precision and accuracy test of the method, durability and robustness of the test method, and estimation of measurement uncertainty. The results show that all test parameters have met the acceptance requirements.
Keywords: griess-saltzman method, nitrogen dioxide, work environment
Osseous Triceps Avulsion in a 12-Year-Old Girl
Authors: Hernandez Sean G. , McQueen Ryan G. , Erickson John B. 
Published: July 2024

Case:
A 12-year-old girl presented with significant right elbow pain following a fall during soccer which caused an osseous triceps avulsion injury and nondisplaced type II Salter-Harris radial neck fracture. The patient was treated with successful open repair utilizing suture anchor fixation, resulting in full return of function and return to previous activities.

Conclusion:
Timely and accurate diagnosis and treatment of displaced triceps sleeve avulsion injuries is critical and can result in excellent patient outcomes and return to previous functional level. This unique case contributes to the diagnosis and management of this rare condition in pediatric populations.
Divergent pathogenic dynamics of immature tick-borne and mosquito-borne flaviviruses: a paradigm shift in prM-containing particle infectivity
Authors: Ruzek Daniel , Holoubek Jiri , Salat Jiri , Matkovic Milos , Bednar Petr , Novotny Pavel , Hradilek Martin , Majerova Tatana , Rosendal Ebba , Eyer Ludek , Fortova Andrea , Duskova Michaela , Sakyi Lesley Bell- , Överby Anna , Cavalli Andrea 
Published: July 2024

Abstract

Maturing flaviviruses undergo pH-dependent conformational changes, transitioning from trimeric pre-membrane protein prM and envelope protein E (prM-E) complexes to dimeric E with cleaved prM. However, little is known about the intermediate maturation stages and whether immature virions contribute to infection. Here we demonstrated that immature prM-containing particles of tick-borne flaviviruses—tick-borne encephalitis virus (TBEV), Langat virus, and louping ill virus—exhibited infectivity in mammalian cells under physiological conditions. This finding challenges the long-standing assumption that prM-containing flavivirus particles are non-infectious, as is the case for immature mosquito-borne flaviviruses, including Usutu virus, Zika virus, and West Nile virus (WNV). In a mouse model, prM-TBEV exhibited high pathogenicity, contrasting with the reduced pathogenicity of prM-WNV. Structural modelling, functional validation, and site-directed mutagenesis revealed interactions within the prM-E complex that influence pH sensitivity, furin cleavage site accessibility, and virus infectivity. This study, therefore, elucidates the distinctive dynamics of infectivity of tick- and mosquito-borne flaviviruses.
CD38+ Alveolar macrophages mediate early control of M. tuberculosis proliferation in the lung
Authors: Russell David , Pisu Davide , Mattila Joshua , Johnston Luana 
Published: July 2024

Abstract

Tuberculosis, caused by M.tuberculosis (Mtb), remains an enduring global health challenge, especially given the limited efficacy of current therapeutic interventions. Much of existing research has focused on immune failure as a driver of tuberculosis. However, the crucial role of host macrophage biology in controlling the disease remains underappreciated. While we have gained deeper insights into how alveolar macrophages (AMs) interact with Mtb, the precise AM subsets that mediate protection and potentially prevent tuberculosis progression have yet to be identified. In this study, we employed multi-modal scRNA-seq analyses to evaluate the functional roles of diverse macrophage subpopulations across different infection timepoints, allowing us to delineate the dynamic landscape of controller and permissive AM populations during the course of infection.
Our analyses at specific time-intervals post-Mtb challenge revealed macrophage populations transitioning between distinct anti- and pro-inflammatory states. Notably, early in Mtb infection, CD38- AMs showed a muted response. As infection progressed, we observed a phenotypic shift in AMs, with CD38+ monocyte-derived AMs (moAMs) and a subset of tissue-resident AMs (TR-AMs) emerging as significant controllers of bacterial growth. Furthermore, scATAC-seq analysis of naïve lungs demonstrated that CD38+ TR-AMs possessed a distinct chromatin signature prior to infection, indicative of epigenetic priming and predisposition to a pro-inflammatory response. BCG intranasal immunization increased the numbers of CD38+ macrophages, substantially enhancing their capability to restrict Mtb growth.
Collectively, our findings emphasize the pivotal, dynamic roles of different macrophage subsets in TB infection and reveal rational pathways for the development of improved vaccines and immunotherapeutic strategies.
Hemodynamic Effect of Handgrip During Cyclic Exercise: Study Protocol for a Randomized Crossover Clinical Trial
Authors: Sacramento Marvyn de Santana do , Leite Josias Melo , de Oliveira Alice Miranda , Barbosa Ramon Martins , Souza Pedro Elias Santos , Petto Jefferson 
Published: July 2024

Abstract

Objective: To test the hypothesis that isometric contraction with the Handgrip device modulates the response of heart rate, systolic and diastolic blood pressure, double product, and subjective perception of exertion (Borg) during cyclic exercise.
Method: This randomized crossover clinical trial consists of three intervention arms. Forty male volunteers aged between 20 and 30 will be recruited. After screening, the volunteers will be randomized to treatment protocols (I: without HG; II: with HG at 30% of Handgrip Strength - HGS and III: with HG at 50% of HGS) which involve performing cyclic exercise on a treadmill, with four sprints at moderate intensity. The data will be presented by the variation (∆) of the sprint-rest and post-exercise-rest moments. The one-way Analysis of Variance (ANOVA) test will be performed in the case of symmetrical distribution and Kruskal-Wallys for non-parametric distribution, to analyze the three protocols during the same phases and then the same test to evaluate the individual responses over time. A p≤0.05 will be considered statistically significant.
Impact of the project: This study will provide answers to the hemodynamic effects of isometric activity with handgrip associated with cyclic exercise and, if the hypotheses of this study are confirmed, we will have robust mechanistic evidence to broaden the field of scientific exploration in different clinical contexts.
Clinical trial registration:
Brazilian Registry of Clinical Trials (REBEC): RBR-78fhyrf, registered on November 17, 2023.
Funding: Postgraduate Support Program for Private IES (PROSUP - CAPES) of the Bahiana School of Medicine and Public Health.
Navigating the Future of Learning: A Systematic Review of AI-Driven Intelligent Tutoring Systems (ITS) in K-12 Education
Authors: Charland Patrick , Létourneau Angélique , Martineau Marion Deslandes , Boasen Jared , Léger Pierre-Majorique 
Published: July 2024

Abstract

The use of artificial intelligence in education (AIEd) has grown exponentially in the last decade, particularly using intelligent tutoring systems (ITSs). Despite the increased use of ITSs and their promise to improve learning, their real educational value remains unclear. Therefore, this systematic review aims to identify which experimental designs are currently used to evaluate the effects of ITSs and what are the effects of ITSs on K-12 students' learning and performance. Studies retrieved from ERIC USDE and Scopus databases reporting effects of an ITS in a formal learning setting published after 2009 were screened and the data extracted was categorized by experimental design. The 20 studies analyzed in this systematic review included a total of 2853 students (N = 2853), predominantly in middle and high school Science, Technology, Engineering and Mathematics (STEM) -related classes. These studies used quasi-experimental designs with varying intervention durations, with half of them categorized as very short. Some studies reported positive effects of ITSs on learning and performance in contrast to traditional teaching. However, the effects were found to be mitigated when compared to non-intelligent tutoring systems. The included studies have identified optimal conditions or contexts for the application of specific ITSs. Overall, our findings suggest that the effects of ITSs on learning and performance in K-12 education are generally positive. However, additional research with longer interventions and increased sample sizes with greater diversity is warranted. Additionally, the ethical implications of using AI for teaching should be investigated.
Multigram-scale Synthesis of Volasertib, an Inhibitor of Polo-like Kinases in Clinical Evaluation
Authors: Wang Kang , Zhao Dong , Jin Mingli , Li Yuan , Sun Lei , Zhu Yanli , Wang Chen , Li Shuang , Wang Yu , Miao Qianying , Chen Xiao , Zhao Yanfang , Hou Yunlei 
Published: July 2024

Abstract

This paper described the development of a practical, improved and efficient method for the multigram-scale synthesis of Volasertib, an injectable bioavailable potent and selective inhibitor of PLK1. The key to this optimization was the design and development of a novel synthetic strategy, which involved the preparation of key intermediate 4-amino-N-{4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-3-methoxybenzamide (W-5) through nitro reduction sequence and (7R)-2-Chloro-7-ethyl-7,8-dihydro-8-(1-methylethyl)-6(5H)-pteridinone (W-11) through reductive cyclization and N-methylation reaction. The developed process provided 46.1% overall yield, which enabled us to rapidly synthesize multi-gram quantities of Volasertib in 99.42% purity.
TARGET Based m 6 A Methylation-Related Genes Predict Prognosis Relapsed B-cell Acute Lymphoblastic Leukemia
Authors: Qiu Kun-yin , Liao Xiong-yu , Fang Jian-pei , Zhou Dun-hua 
Published: July 2024

Abstract

Purpose
The current study aim to investigate the significance of N6-methyladenosine (m6A) methylationrelated genes in the clinical prognosis of childhood relapsed B-cell acute lymphoblastic leukemia patient.
Methods
Transcriptome data and corresponding clinical data on m6A methylation-related genes (including 20 genes) were obtained from the Therapeutically Applicable Research To Generate Effective Treatments (TARGET) database.
Results
The bone marrow (BM) samples of 134 newly diagnosed (naive) and 116 relapsed B-ALL from TARGET were enrolled in the current study. Three genes (FTO, HNRNPC, RBM15B) showed significant up-regulation in relapsed B-ALL compared with that in naive B-ALL.The three genes had a significantly worse survival (P < 0.05). The LASSO Cox regression model was used to select the most predictive genes as prognostic indicators, and YTHDC1 and FTO were identified as prognostic factors for relapsed ALL. Finally, the results of multivariate regression analysis showed that the risk score of m6A methylation-related genes was an independent prognostic factor in relapsed B-ALL (P < 0.05).
Conclusion
We found that the expression levels of m6A methylation-related genes were different in naive and relapsed patients with B-ALL and correlated with survival and prognosis.This implies that m6A methylation-related genes may be promising prognostic indicators or therapeutic targets for relapsed B-ALL.
ATF3 is required for the prevention of cardiomyopathy via the regulation of mitochondrial oxidative stress
Authors: Kim Won-Ho , Jeong Myong-Ho , Jeong Yideul , Cho Su-Yeon , Lee Seung Hee , Kim Geun-Young , Kim Min-Ju 
Published: July 2024

Abstract

Activating transcription factor 3 (ATF3) is a critical regulator for cellular stress responses and is implicated in stress-induced cardiac hypertrophy and fibrosis. However, the role of ATF3 in cardiomyopathy remains controversial. Here, we demonstrate that ATF3 plays a cardioprotective role by controlling mitochondrial oxidative stress in angiotensin II (Ang II)-triggered cardiomyopathy. The expression of ATF3 was significantly upregulated in hypertrophic hearts chronically infused with Ang II, which correlated with Ang II-treated cardiomyocytes. In neonatal mouse ventricular myocytes (NMVMs), Ang II-elicited hypertrophic responses were either aggravated or suppressed by ATF3 depletion or overexpression, respectively. Similar results were also obtained in human embryonic stem cell-derived cardiomyocytes (hESC-CMs). To analyze the direct role of ATF3 in cardiomyopathy, we generated mice with a cardiomyocyte-specific ATF3 deletion using a tamoxifen-inducible Cre-recombinase (αMHC-MerCreMer/loxP) system. In response to Ang II infusion, mice with cardiomyocyte-specific ablation of ATF3 (ATF3 cKO) exhibited aggravated cardiac hypertrophy and fibrosis concurrent with decreased fractional shortening and ejection fraction. In addition, the transcriptome analysis of control and cKO hearts revealed alterations in genes related to mitochondrial function and organization. In particular, the expression of Sirt3/Sod2 transcripts, well known as a mechanism for regulating mitochondrial oxidative stress, was increased in Ang II-infused mice, which was downregulated by the depletion of ATF3, suggesting the cardioprotective function of ATF3 through the improvement of mitochondrial function. These results suggest that ATF3 may be a potential therapeutic target for hypertrophic cardiomyopathy.
The relationship between Happiness with Sleep quality and Self-care ability in community-dwelling older adults
Authors: Bakhtiyary Milad , Sharifi Farshad , Karimi Keyvan , Salehpoor-emran Mohammad , Mirzadeh Fatemeh Sadat , Afshar Pouya Farokhnezhad 
Published: July 2024

Abstract

Background
Population aging is one of the challenges of the future, which requires large-scale planning. Examining happiness and its relationship with the quality of sleep and self-care is an aspect that has received less attention in old age. Therefore, this study aimed to determine the relationship between happiness with sleep quality and self-care ability in community-dwelling older adults.
Methods
This is a cross-sectional correlation descriptive research. We selected 306 eligible community-dwelling older adults by multistage sampling referring to comprehensive health service centers. The Oxford Happiness Inventory (OHI), Pittsburgh Sleep Quality Questionnaire (PSQI), and The Self-care Ability Scale for the Elderly (SASE) were used to collect data. Data were analyzed using SPSS v.27 software by Spearman test, univariate and multivariate regression.
Results
The findings showed that 58% of older adults were male, 67.6% were married, and 44% were retired. Multivariate logistic regression showed a significant relationship between self-care ability (β = -1.50, p < 0.001) and sleep quality (β = 0.50, p < 0.001) with happiness.
Conclusion
The level of happiness is directly affected by the self-care ability and sleep quality. Therefore, policymakers and planners should pay more attention to the importance of happiness and its relationship to sleep and self-care ability.