bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timing and Determinants of the Introduction of Complementary Foods in Kuwait
Authors: Scott Jane A. , Dashti Manal , Al-Sughayer Mona , Edwards Christine A. 
Published: April 2015

Background: The early introduction of complementary foods is common in Middle Eastern countries but little is known about the determinants of this practice in this region. Objectives: This prospective cohort study conducted from October 2007 to October 2008 investigated the determinants of the very early (before 17 weeks) introduction of complementary foods in Kuwait and compared rates of this practice against rates reported in the mid-1990s. Methods: A total of 373 women were recruited from maternity hospitals in Kuwait City and followed to 26 weeks postpartum. Data on complementary feeding practices were available from 303 women. Multivariate logistic regression was used to estimate the association of very early introduction of complementary foods with infant sex and maternal characteristics including age, years of education, employment intentions at 6 months postpartum, parity, prepregnancy body mass index, and prepregnancy smoking status. Results: All infants had received complementary foods by 26 weeks of age, with 30.4% receiving complementary foods before 17 weeks of age. Women born in other Arabic countries were less likely to introduce complementary foods before 17 weeks (adjusted odds ratio [adj OR] = 0.40; 95% confidence interval [CI], 0.22-0.73) than women born in Kuwait. Women who were exclusively formula feeding at 6 weeks postpartum were less likely to introduce complementary foods before 17 weeks (adj OR = 0.40; 95% CI, 0.23-0.71) than women who were still breastfeeding. Conclusion: Compared to the mid-1990s, fewer infants in Kuwait were receiving complementary foods before 17 weeks. Nevertheless, all infants had received complementary foods by 6 months of age.
Somatostatin receptor subtype 2 in high-grade gliomas: PET/CT with 68Ga-DOTA-peptides, correlation to prognostic markers, and implications for targeted radiotherapy
Authors: Kiviniemi Aida , Gardberg Maria , Frantzén Janek , Pesola Marko , Vuorinen Ville , Parkkola Riitta , Tolvanen Tuula , Suilamo Sami , Johansson Jarkko , Luoto Pauliina , Kemppainen Jukka , Roivainen Anne , Minn Heikki 
Published: April 2015

Abstract

Background
High-grade gliomas (HGGs) express somatostatin receptors (SSTR), rendering them candidates for peptide receptor radionuclide therapy (PRRT). Our purpose was to evaluate the potential of 68Ga-DOTA-1-Nal3-octreotide (68Ga-DOTANOC) or 68Ga-DOTA-Tyr3-octreotide (68Ga-DOTATOC) to target SSTR subtype 2 (SSTR2) in HGGs, and to study the association between SSTR2 expression and established biomarkers.

Methods
Twenty-seven patients (mean age 52 years) with primary or recurrent HGG prospectively underwent 68Ga-DOTA-peptide positron emission tomography/computed tomography (PET/CT) before resection. Maximum standardized uptake values (SUVmax) and receptor binding potential (BP) were calculated on PET/CT and disruption of blood–brain barrier (BBB) from contrast-enhanced T1-weighted magnetic resonance imaging (MRI-T1-Gad). Tumor volume concordance between PET and MRI-T1-Gad was assessed by Dice similarity coefficient (DC) and correlation by Spearman’s rank. Immunohistochemically determined SSTR2 status was compared to receptor imaging findings, prognostic biomarkers, and survival with Kruskal-Wallis, Pearson chi-square, and multivariate Cox regression, respectively.

Results
All 19 HGGs with disrupted BBB demonstrated tracer uptake. Tumor SUVmax (2.25 ± 1.33) correlated with MRI-T1-Gad (r = 0.713, P = 0.001) although DC 0.41 ± 0.19 suggested limited concordance. SSTR2 immunohistochemistry was regarded as positive in nine HGGs (32%) but no correlation with SUVmax or BP was found. By contrast, SSTR2 expression was associated with IDH1 mutation (P = 0.007), oligodendroglioma component (P = 0.010), lower grade (P = 0.005), absence of EGFR amplification (P = 0.021), and longer progression-free survival (HR 0.161, CI 0.037 to 0.704, P = 0.015).

Conclusions
In HGGs, uptake of 68Ga-DOTA-peptides is associated with disrupted BBB and cannot be predicted by SSTR2 immunohistochemistry. Thus, PET/CT shows limited value to detect HGGs suitable for PRRT. However, high SSTR2 expression portends favorable outcome along with established biomarkers such as IDH1 mutation.

Trial registration
ClinicalTrials.gov NCT01460706
Applications of order-theoretic fixed point theorems to discontinuous quasi-equilibrium problems
Authors: Zhang Congjun , Wang Yuehu 
Published: April 2015

AbstractIn this paper, we apply order-theoretic fixed point theorems and isotone selection theorems to study quasi-equilibrium problems. Some existence theorems of solutions to quasi-equilibrium problems are obtained on Hilbert lattices, chain-complete lattices and chain-complete posets, respectively. In contrast to many papers on equilibrium problems, our approach is order-theoretic and all results obtained in this paper do not involve any topological continuity with respect to the considered mappings.
The double absorbing boundary method for elastodynamics in homogeneous and layered media
Authors: Rabinovich Daniel , Givoli Dan , Bielak Jacobo , Hagstrom Thomas 
Published: April 2015

Abstract

Background
Recently the Double Absorbing Boundary (DAB) method was introduced as a new approach for solving wave problems in unbounded domains. It has common features to each of two types of existing techniques: local high-order Absorbing Boundary Conditions (ABC) and Perfectly Matched Layers (PML). However, it is different from both and enjoys relative advantages with respect to both.

Methods
The DAB method is based on truncating the unbounded domain to produce a finite computational domain, and on applying a local high-order ABC on two parallel artificial boundaries, which are a small distance apart, and thus form a thin non-reflecting layer. Auxiliary variables are defined on the two boundaries and within the layer, and participate in the numerical scheme. In previous studies DAB was developed for acoustic waves which are solutions to the scalar wave equation. Here the approach is extended to time-dependent elastic waves in homogeneous and layered media. The equations are written in second-order form in space and time. Standard Finite Elements (FE) are used for space discretization and the damped Newmark scheme is used for time discretization.

Results
The performance of the scheme is demonstrated via numerical examples. The DAB was applied to elastodynamics problems in conjunction with the FE method to demonstrate the performance of the method.

Conclusions
DAB is a viable method for solving wave problems in unbounded domains.
Predicting Anthracycline Benefit: TOP2A and CEP17—Not Only but Also
Authors: Bartlett John M.S. , McConkey Christopher C. , Munro Alison F. , Desmedt Christine , Dunn Janet A. , Larsimont Denis P. , O'Malley Frances P. , Cameron David A. , Earl Helena M. , Poole Christopher J. , Shepherd Lois E. , Cardoso Fatima , Jensen Maj-Britt , Caldas Carlos , Twelves Christopher J. , Rea Daniel W. , Ejlertsen Bent , Di Leo Angelo , Pritchard Kathleen I. 
Published: April 2015

Purpose Evidence supporting the clinical utility of predictive biomarkers of anthracycline activity is weak, with a recent meta-analysis failing to provide strong evidence for either HER2 or TOP2A. Having previously shown that duplication of chromosome 17 pericentromeric alpha satellite as measured with a centromere enumeration probe (CEP17) predicted sensitivity to anthracyclines, we report here an individual patient–level pooled analysis of data from five trials comparing anthracycline-based chemotherapy with CMF (cyclophosphamide, methotrexate, and fluorouracil) as adjuvant chemotherapy for early breast cancer. Patients and Methods Fluorescent in situ hybridization for CEP17, HER2, and TOP2A was performed in three laboratories on samples from 3,846 of 4,864 eligible patients from five trials evaluating anthracycline-containing chemotherapy versus CMF. Methodologic differences did not affect HER2-to-CEP17 ratios but necessitated different definitions for CEP17 duplication: > 1.86 observed copies per cell for BR9601, NEAT, Belgian, and DBCG89D trials and > 2.25 for the MA.5 trial. Results Fluorescent in situ hybridization data were available in 89.3% (HER2), 83.9% (CEP17), and 80.6% (TOP2A) of 3,846 patient cases with available tissue. Both CEP17and TOP2A treatment-by-marker interactions remained significant in adjusted analyses for recurrence-free and overall survival, whereas HER2 did not. A combined CEP17 and TOP2A–adjusted model predicted anthracycline benefit across all five trials for both recurrence-free (hazard ratio, 0.64; 95% CI, 0.51 to 0.82; P = .001) and overall survival (hazard ratio, 0.66; 95% CI, 0.51 to 0.85; P = .005). Conclusion This prospectively planned individual-patient pooled analysis of patient cases from five adjuvant trials confirms that patients whose tumors harbor either CEP17 duplication or TOP2A aberrations, but not HER2 amplification, benefit from adjuvant anthracycline chemotherapy.
Impact of Specific Epidermal Growth Factor Receptor (EGFR) Mutations and Clinical Characteristics on Outcomes After Treatment With EGFR Tyrosine Kinase Inhibitors Versus Chemotherapy in EGFR-Mutant Lung Cancer: A Meta-Analysis
Authors: Lee Chee Khoon , Wu Yi-Long , Ding Pei Ni , Lord Sarah J. , Inoue Akira , Zhou Caicun , Mitsudomi Tetsuya , Rosell Rafael , Pavlakis Nick , Links Matthew , Gebski Val , Gralla Richard J. , Yang James Chih-Hsin 
Published: April 2015

Purpose We examined the impact of different epidermal growth factor receptor (EGFR) mutations and clinical characteristics on progression-free survival (PFS) in patients with advanced EGFR-mutated non–small-cell lung cancer treated with EGFR tyrosine kinase inhibitors (TKIs) as first-line therapy. Patients and Methods This meta-analysis included randomized trials comparing EGFR TKIs with chemotherapy. We calculated hazard ratios (HRs) and 95% CIs for PFS for the trial population and prespecified subgroups and calculated pooled estimates of treatment efficacy using the fixed-effects inverse-variance-weighted method. All statistical tests were two sided. Results In seven eligible trials (1,649 patients), EGFR TKIs, compared with chemotherapy, significantly prolonged PFS overall (HR, 0.37; 95% CI, 0.32 to 0.42) and in all subgroups. For tumors with exon 19 deletions, the benefit was 50% greater (HR, 0.24; 95% CI, 0.20 to 0.29) than for tumors with exon 21 L858R substitution (HR, 0.48; 95% CI, 0.39 to 0.58; Pinteraction < .001). Never-smokers had a 36% greater benefit (HR, 0.32; 95% CI, 0.27 to 0.37) than current or former smokers (HR, 0.50; 95% CI, 0.40 to 0.63; Pinteraction < .001). Women had a 27% greater benefit (HR, 0.33; 95% CI, 0.28 to 0.38) than men (HR, 0.45; 95% CI, 0.36 to 0.55; treatment-sex interaction P = .02). Performance status, age, ethnicity, and tumor histology did not significantly predict additional benefit from EGFR TKIs. Conclusion Although EGFR TKIs significantly prolonged PFS overall and in all subgroups, compared with chemotherapy, greater benefits were observed in those with exon 19 deletions, never-smokers, and women. These findings should enhance drug development and economic analyses, as well as the design and interpretation of clinical trials.
Subgroup Analyses in Reporting of Phase III Clinical Trials in Solid Tumors
Authors: Zhang Sheng , Liang Fei , Li Wenfeng , Hu Xichun 
Published: April 2015

Purpose Treatment decisions in clinical oncology are guided by results from phase III randomized clinical trials (RCTs). The results of subgroup analyses may be potentially important in individualizing patient care. We investigated the appropriateness of the use and interpretation of subgroup analyses in oncology RCTs on the basis of the CONSORT statement requirements. Methods Phase III RCTs published between January 1, 2011, and December 31, 2013, were reviewed to identify eligible studies of solid tumor treatments. Information related to the subgroup analyses included prespecification, number, subgroup factors, interaction test use, and claim of subgroup difference. Results A total of 221 publications reporting data on 184,500 patients were analyzed. One hundred eighty-eight (85%) RCTs were reported with subgroup analyses. Of those, 146 (78%) trials were reported with at least six subgroups. For the majority of trials with subgroup analyses (173; 92%), the actual number of subgroup analyses conducted cannot be determined. Only 59 (31%) RCTs were reported with fully prespecified subgroups and only 64 (34%) trials were reported with interaction tests. In addition, 102 (54%) RCTs were reported with claims of subgroup differences. Of those, only 18 claims of RCTs (18%) were based on significant interaction test results. Conclusion The reporting of subgroup analyses in contemporary oncology RCTs is neither uniform nor complete; it requires improvement to ensure consistency and to provide critical information for guiding patient care. Major problems include testing of a large number of subgroups, subgroups without prespecifications, and inadequate use of interaction tests.
The stabilizing effect of dehydroepiandrosterone on clinical parameters of metabolic syndrome in patients with schizophrenia treated with olanzapine - a randomized, double-blind trial.
Authors: Holka-Pokorska Justyna , Radzio Rafał , Jarema Marek , Wichniak Adam 
Published: April 2015

CelBadania epidemiologiczne wykazały, że niski poziom dehydroepiandrosteronu łączy się ze zwiększonym ryzykiem rozwoju zespołu metabolicznego. Celem badania była ocena, czy suplementacja dehydroepiandrosteronu w dawce 100mg/dobę u chorych na schizofrenię leczonych olanzapiną wpływa na antropometryczne oraz biochemiczne parametry zespołu metabolicznego.MetodaW dwunastotygodniowym badaniu, podwójnie ślepym, z randomizacją i kontrolą placebo uczestniczyło 55 chorych płci męskiej, z rozpoznaniem schizofrenii paranoidalnej, w wieku 21-59 lat. Otrzymywali oni dehydroepiandrosteron (DHEA) lub placebo w dawce 100mg, jako terapię dodaną do stabilnej dawki olanzapiny (średnio 15 mg/dobę). Oceniano efekty wpływu DHEA lub placebo na wartości lipidogramu, poziomu glikemii na czczo, BMI oraz obwodu pasa.WynikiBadanie ukończyło 45 chorych. Nie wykazano istotnych zmian w zakresie wartości cholesterolu całkowitego, cholesterolu HDL, cholesterolu LDL oraz trójglicerydów w obu podgrupach pacjentów, którzy ukończyli badanie. Wyniki analizy z powtarzalnymi pomiarami w układzie: poziom glikemii na czczo 2x tj. pomiar na początku i na końcu badania x 2 (grupa badawcza i kontrolna), wykazały znaczący efekt interakcji (F =5,7, df= 1,000 p= 0,021). Poziom glikemii znacząco zmalał w podgrupie DHEA. Dodatkowo obserwowano wzrost wartości obwodu pasa w cm (delta= -1,11, t=-2,87; df=20; p=0,01) oraz wartości BMI (delta= -0,48, t=-2,38; df=19; p=0,028) dla podgrupy placebo, przy braku zmian powyższych parametrów dla podgrupy DHEA.WnioskiSuplementacja dehydroepiandrosteronu może wywierać efekt stabilizujący wartości BMI, obwodu pasa oraz glikemii na czczo u chorych na schizofrenię leczonych olanzapiną. Potwierdzenie insulinopodobnego działania dehydroepiandorsteronu w grupie pacjentów ze schizofrenią wymaga jednak przeprowadzenia dalszych badań długoterminowych z zastosowaniem bardziej szczegółowych narzędzi z zakresu oceny biochemicznej metabolizmu glukozy.
Using Digital Service Inventories to Create Customer Value
Authors: Davis Mark M. , Field Joy , Stavrulaki Euthemia 
Published: April 2015

Technology continues to affect today’s businesses in general and services in particular. With the globalization of business, service organizations have access to many of the same external resources. As a result, services must look internally to how they design their delivery processes to increase the value of their offerings. One element that appears to offer such opportunities is the creation of service inventories in the design of the service delivery process. We define service inventory as any tangible or intangible operand resource that is transformed by the service provider with or without customer input and is stored prior to the customer’s arrival. The goal of service inventories is to facilitate the steps in the service delivery process, thereby creating customer value during the service encounter. Within this context, service inventories can be either physical or digital; we focus primarily on the creation of digital service inventories and how they add value for both the provider and the customer. We introduce a framework that relates the degree of customer interaction and the degree of service inventory differentiation to operational “stickiness.” Our objective is to acknowledge the increasing role of technology in the delivery of services, and we discuss how services can leverage this technology by incorporating service inventories into the design of their delivery processes. The resulting synergy from both increasing the level of customer interaction during the value cocreation process and creating service inventories (both of which are integral elements in our framework) provides firms with increased customer satisfaction and loyalty.
Ubiquitous computing, digital failure and citizenship learning in Swedish popular education
Authors: Rahm Lina , Fejes Andreas 
Published: April 2015

Abstract
How do adult students enact citizenship, and what discursive and material conditions make certain enactments more or less possible? This article draws on 37 interviews with adult students at Swedish Folk High Schools and focuses on the everyday material-discursive enactments of interactive media in adult students’ statements about citizenship. Drawing on a post-constructional perspective, the analysis illustrates how students’ statements about citizenship are made possible by ever-present media technologies and the associated practices of ‘living in media’. Students’ statements continuously reiterate how notions of citizenship are entangled with the Internet (and other new media). However, while new media are deeply embedded in the everyday lives of citizens and enables important citizenship enactments, they are also a source of discomfort, giving rise to ambiguous statements. These double-edged statements refer on the one hand to negative implications on physical health, distraction from important tasks and an over-reliance on the Internet as an everyday need, and on the other hand to improved access to information, convivial communities and empowered citizenship.
Students as citizens of their university: Student involvement in programme prioritization
Authors: Steeves Josie 
Published: April 2015

Abstract
Higher education is a rapidly changing environment for policy creation and administration. Since the 1960s students have been included in governing bodies and are viewed as central to the development of a democratic organizational culture at universities. However, many student activists and leaders do not feel their interests are being represented appropriately or adequately within the university. Through an examination of the literature on organizational culture and citizenship, and the use of a brief example from a university in Canada, I posit that students are not core contributing members of the organizational culture of the university and are not included in a significant manner in governance. As a result, they are not ‘citizens’ of universities and are instead seen as ‘clients’. This could have potential impacts on student reactions to changing administrative practices such as programme changes and fee structures.
How to Design for Large-Scale Multi-Stakeholder Co-Creation Initiatives: Reframing Crime Prevention Challenges with the Police in Denmark
Authors: Degnegaard Rex , Degnegaard Stine , Coughlan Peter 
Published: April 2015

Abstract
The police in Denmark have made a strategic intent to engage and activate external stakeholders in crime prevention efforts. However, knowledge of how to unfold the potential of such multi-stakeholder, co-creation-based business models is scarce. The current study was initiated to explore the roles of design thinking and strategic visualization in designing for multi-stakeholder, co-creation-based business models. The study is based on the design, execution and results of a workshop with the Danish police in which almost 100 innovation professionals worked on designing solutions for crime prevention challenges identified and put forth by the Danish police. The article points to how design thinking and strategic visualization can be essential vehicles in realizing the potential of co-creation-based business models by allowing for emergence, while at the same time creating clarity that potentially leads to a productive reframing of the targeted challenge.
Eastern Desekratorz and Nuclear Metal Lust:1 Performing ‘Authentic’ black metal in Malaysian Borneo
Authors: Ferrarese Marco 
Published: April 2015

Abstract
Among the globalized metal scenes of South East Asia, Malaysian Borneo’s black metal (BM) demonstrates a great deal of referencing to the satanic themes and sonic rawness of the first wave of western BM bands such as Venom and Bathory. However, the ways in which Malaysian Borneo black metallers perform what they perceive to be ‘authentic’ BM identity clash with the reality of their everyday lives. In fact, their social backgrounds seem incompatible with the features of BM authenticity they strive to perform. What remains unclear is how and why Malaysian Borneo BM fans and musicians manifested their authentic belonging to this subculture by adopting the genre’s dominant anti-Christian imagery, when in most instances Christianity is not their religion of choice. Qualitative data were collected by ten weeks of ethnographic fieldwork and semi-structured interviews with eight members of Malaysian Borneo’s BM scene in the states of Sarawak and Sabah. Findings were supported by content analysis of local BM recordings, lyrics and interviews published in independently produced metal fanzines. BM ‘authenticity’ in Malaysian Borneo emerged as a theatrical pursuit of the most shocking global examples of primeval BM, which allows for a troubled, precarious coexistence between perceived ‘authentic’ BM aspirations and everyday social life in the respondents’ lives.
Re-conceptualizing women’s marginalization in heavy metal: A feminist post-structuralist perspective
Authors: Riches Gabby 
Published: April 2015

Abstract
The continuing expansion of the field of metal music studies has evoked an increased interest from scholars to critically explore women’s participation within heavy metal, along with other axes of identity, from a variety of theoretical perspectives and methodological approaches. Since Weinstein’s ([1991] 2000) canonical sociological study of heavy metal the notion that heavy metal is masculinist remains theoretically pervasive in gendered analyzes of heavy metal and its practices. The upcoming special issue ‘Metal and Marginalization’ signals the ‘disruptive return of the excluded’ (Butler 2004) whereby concepts of marginalization, inclusivity and agency are called into question. Drawing upon my own doctoral research, this article deconstructs the synonymous and obstructive relationship heavy metal has with masculinity by focusing on women’s embodied practices. Influenced by Butler’s (1990) theory of performativity and poststructural notions of ‘equality’ and ‘inclusivity’ (Butler et al. 1997; Scott 1988), I discuss how heavy metal scenes should be considered spaces of equality and potentiality as they permit different performativities and understandings; thus, creating real pathways for doing metal fandom differently.