bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Cr Content on Hot Deformation Behavior and Microstructure Evolution of Cu–Cr–Ni Bridge Weathering Steel
Authors: Xu Gaoshan , Zhang Tenghao , Zhang Ke , Xu Dangwei , Huang Zhong , Li Jinghui , Li Zhaodong , Huang Zhenyi 
Published: August 2024

The hot compression tests (T = 850–1100 °C,  = 0.1–10 s−1) of Cu–Cr–Ni bridge weathering steel with different Cr content (0.46% (#1), 0.64% (#2)) were performed on Gleeble‐3800‐D thermomechanical simulator. The effects of Cr content on hot deformation and microstructure evolution are systematically investigated by the Arrhenius constitutive equation, processing map, electron backscatter diffraction technology, and transmission electron microscope. In the results, it is demonstrated that the increase of Cr content from 0.46% to 0.64% enhances the solution strengthening and inhibits the dynamic recrystallization of the experimental steels during hot compression, resulting in the increase of flow stress. The Arrhenius constitutive equation with strain compensation is constructed. The increase of Cr content results in an augmentation of hot deformation activation energy, rising from Q#1 = 358.47 kJ mol−1 to Q#2 = 396.79 kJ mol−1, causing the increase of deformation resistance of Cu–Cr–Ni bridge weathering steel in hot compression. The optimal hot processing window of #1 and #2 experimental steels is as follows:  = 0.1–0.2 s−1, T = 1050–1100 °C,  = 0.1–0.15 s−1, and T = 1050–1100 °C, the increase of Cr content leads to the narrowing of the hot processing window of the experimental steels.
Ertüchtigung des Brückengeräts SB30
Authors: Klähne Thomas , Schöne Julian , Schreiber Oliver , Gautier François , Stihl Thomas , Heiland Uwe 
Published: August 2024

AbstractDas Bundesministerium für Digitales und Verkehr (BMDV) und die Fa. SYSTEC GmbH verfügen über ca. 7500 t der Systembrücke SB30 für den Einsatz beim Katastrophenschutz und für temporäre Maßnahmen bei der Instandsetzung der Verkehrsinfrastruktur. Allerdings genügt das in den 1970er‐Jahren in der DDR entwickelte Brückengerät nicht mehr den heutigen Anforderungen und ist dementsprechend nur noch stark eingeschränkt verwendbar. Zur Vermeidung einer ressourcenintensiven Ersatzbeschaffung dieser Vorräte entwickelt die Fa. SYSTEC GmbH gemeinsam mit SEH Engineering GmbH und dem Ingenieurbüro KLÄHNE BUNG verschiedene Ertüchtigungskonzepte, welche eine Weiterverwendung des überalterten Brückengeräts SB30 im Sinne des von der Europäischen Kommission ausgerufenen Green Deal ermöglichen.
In vivo CRISPR‐Cas9 expression in Candida glabrata, Candida bracarensis, and Candida nivariensis: A versatile tool to study chromosomal break repair
Authors: Métivier Killian , Zhou‐Li Youfang , Fairhead Cécile 
Published: August 2024

AbstractThe CRISPR‐Cas9 system is extremely useful for genome editing in many species, including the model yeast Saccharomyces cerevisiae, and other yeast species. We have previously reported the use of an inducible CRISPR‐Cas9 system in Candida glabrata, which allows genome editing but also the study of double‐strand break (DSB) repair. We report, in this study, a comparable system for C. glabrata, relying on a new plasmid, which is more stable than the previous one. We also report the use of this plasmid to induce DSBs in two additional human pathogens, Candida bracarensis and Candida nivariensis. We examine lethality induced by an in vivo DSB in the three species and describe the different types of nonhomologous end‐joining (NHEJ) events detected in these three pathogens.
Mining and Metallurgy in Early Imperial Russia
Authors: Graber Anna 
Published: August 2024

AbstractThe global turn in the history of science enables us to account for the non-Western and transcultural origins of modern science. While the knowledge traditions of some non-Western empires have begun receiving substantial historical treatment, the Russian Empire has been little considered by historians of science and technology. This gap in the literature is particularly surprising in the case of the earth and mining sciences given Russia’s dominance in early modern Eurasian metallurgy. The aim of this chapter is to bring together two literatures—the history of Russian imperial mining and the global history of earth science and mining technology—that are not often in conversation with one another. As historians of an empire that was independent yet deeply engaged with the earth and mining sciences of a variety of Wests, Russianists offer novel approaches to the some of the shared issues facing scholars of global science history.
Changemakers: Designers in Healthcare
Authors: Miller Evonne , Winter Abbe 
Published: August 2024

AbstractThis chapter makes the argument for why a transformative design-led approach is so urgently needed in healthcare. Healthcare and design are both about creating transformation through innovative change, but their approaches differ. This chapter describes the 4-year HEAL (Healthcare Excellence AcceLerator) collaboration between clinicians and designers in Queensland, Australia to tackle wicked problems, using the distinct design approaches of design thinking, design doing, prototyping, and implementing. As healthcare systems need continuous innovation, health is particularly suitable for the iterative, human-centred and interdisciplinary methods of design—where (1) challenges are reframed as opportunities for discovery and innovation, with (2) a focus on ongoing engagement, co-creating, testing, and refining implementable solutions, through (3) empathy, visual thinking, and rapid prototyping. Inherently optimistic, user-centred, and experiential, our design-led approach is a constructive new approach to healthcare innovation, and for creating transformative solutions with and for end-users: consumers and clinicians.
Improving Interpreter Service Uptake and Access to Just Healthcare for CALD Consumers: Reflections from Clinicians and Designers on Animation and Experience-Based Co-design (EBCD)
Authors: Rieger Janice , Johnstone Sarah , Beaver Karen , Chari Ruby , Brunner Thalia 
Published: August 2024

AbstractThis chapter describes a common problem in healthcare—finding ways to increase the use of interpreter services for culturally and linguistically diverse (CALD) consumers. The team took a threefold approach, beginning with a survey of clinicians, followed by a short (90 min) workshop with clinicians to more deeply investigate their reasons for not using the available interpreter services, and finally the development of an animated resource that could be played and shared to encourage clinicians to schedule interpreter services for their CALD consumers.
Empathy in Action: A Rapid Design Thinking Sprint for Paediatric Pain—Perspective-Storming, Pain Points, and the Power of Personas
Authors: Miller Evonne 
Published: August 2024

AbstractThis chapter deeply describes the design thinking process and contextualises it in the context of what is known as a sprint—a focused time dedicated to one topic. The design sprint discussed here was about reducing procedural pain for paediatric patients at the Queensland Children’s Hospital, during their annual week-long event Dream Big. The unique aspect of the design sprint for that event was its short time, taking place over only 1 h.
Asking the Right Questions: Cancer Wellness and Stroke Care
Authors: Cheers Jessica 
Published: August 2024

AbstractThis chapter provides a reflective lens on two separate projects from the HEAL initiative, which were both undertaken by HDR Intern and Experience Designer Jessica Cheers. The first, Cancer Wellness at the Princess Alexandra hospital, describes the experience of being a designer coming into a partly-planned solution to the problem of there being too much wellbeing information available in too many places for cancer patients, to the point that they were overwhelmed and could not select what they needed. By taking them through a design thinking process, the team were able to identify the critical information that cancer patients needed at different stages of their journey. The second project, on Stroke Care, comprehensively mapped the different experiences (including waiting times) that stroke patients had across the state of Queensland. This tool enabled clinicians and decision-makers to prioritise the best solutions for each case.
Thinking Differently: Six Principles for Crafting Rapid Co-design and Design Thinking Sprints as ‘Transformative Learning Experiences in Healthcare’
Authors: Miller Evonne 
Published: August 2024

AbstractThis chapter presents six principles drawn from lived experience of running over 30 rapid design thinking and co-design sprints on diverse healthcare topics as part of the HEAL initiative. Starting with an explanation of the value of a co-design approach to healthcare and situating these activities as transformative learning experiences for attendees, the six principles address the empathetic role of the facilitator, the importance of looking for the positive, the need to work through the hard stuff, the value of enabling consumers to have their say, ways to facilitate important conversations, and how to ensure a memorable experience. The chapter ends with a research poem that highlights the importance of thinking differently about design sprints.
Bringing the University to the Hospital: QUT Design Internships at the Queensland Children’s Hospital Paediatric Intensive Care Unit (PICU)
Authors: Tyurina Anastasia , Winter Abigail , Ness Wilson Leighann 
Published: August 2024

AbstractThis chapter is the second of three chapters in this book that discuss the HEAL project’s work with the Paediatric Intensive Care Unit (PICU) at the Queensland Children’s Hospital in 2021. This chapter describes the activities of a group of undergraduate students undertaking an industry placement, known as Work Integrated Learning (WIL), to support the design artefacts that needed to be created, including those for the PICU Marketplace data gathering. The project also evaluated whether the students who took part in this industry placement project had expanded their professional identity to consider working as a designer in healthcare as a potential future career aspiration.
Exploring Clinical Healthcare Challenges and Solutions Through a Design Thinking Education Program for Senior Health Professionals
Authors: Matthews Judy , Wright Natalie 
Published: August 2024

AbstractThe purpose of this chapter is to reflect on the value of teaching clinicians a design thinking human-centred process through exploring the challenges/issues/problems from their own practice settings, developing their collaborative prototyping mindset, and generating and testing new solutions. This chapter focuses on an introductory program for health professionals to increase their awareness of the benefits of engaging in the design thinking process and new ways of thinking, doing, and working, to address health service quality improvement issues. Using insights from their patients’ experiences, clinicians worked with their colleagues and designers in a half-day workshop to co-design, prototype and test some potential solutions to their patients’ health-related problems. These workshops were supported by an online program of five modules introducing further useful tools for implementing design thinking in healthcare settings during the five phases of the design process, and a recorded discussion capturing reflections of members of the QUT HEAL Design Lab and their experiences working with clinicians. Team reflections as well as recommendations for future educational interventions and implications for designers working with medical professionals are discussed.
‘It Takes a Village’: The Power of Conceptual Framing in the Participatory Redesign of Family-Centred Care in a Paediatric Intensive Care Unit
Authors: Wright Natalie , Wilson Leighann Ness , Tyurina Anastasia , Harnischfeger Jane , Johnstone Sarah , Matthews Judy 
Published: August 2024

AbstractFamily-centred care (FCC) is a global approach to the planning, delivery, and evaluation of safe, quality health care that is grounded in mutually-beneficial partnerships among health care providers, patients, and families. This perspective not only relates to direct care interactions, but also to quality improvement, safety initiatives, education of health professionals, research, facility design, and policy development. This chapter presents and discusses the process and outcomes of a truly collaborative and values-led participatory design quality improvement project undertaken by the QUT HEAL team at the Queensland Children’s Hospital (QCH) Paediatric Intensive Care Unit (PICU) in Brisbane, Australia in 2020–2021, to optimise family-centred care quality through a spatial redesign proposal. It discusses the importance of conceptual framing at the outset of the project to galvanise a large team of staff, current and past parents and families, and hospital administration to support the three core principles of FCC—partnership, participation, and protection, and promote the health and well-being of individuals and families both through the design process and in the final conceptual interior design outcome.
Designing Hospital Emergency Departments for a Post Pandemic World: The Value of a BaSE Mindset—Biophilia (Natural), Salutogenesis (Healthy), and Eudaimonia (Contentment) in Architectural Design
Authors: Burton Lindy Osborne , Miller Evonne , Carthey Jane , Schofield Scott 
Published: August 2024

AbstractThis chapter reports on research conducted across Australia with clinicians during the COVID-19 pandemic in 2020–21. The researchers worked with clinicians in hospital Emergency departments, often the first point of contact at the hospital for many consumers, to investigate ways to make the layout and wayfinding easier, both for consumers and clinicians. Research suggests that a biophilic (bringing in elements of nature), salutogenic (promoting good health), and eudaimonic (supporting happiness and contentment) environment will make Emergency departments in hospitals more positive places, and clinician feedback provides specific examples of how these architectural goals could be achieved.
A computation of two-loop six-point Feynman integrals in dimensional regularization
Authors: Henn Johannes , Matijašić Antonela , Miczajka Julian , Peraro Tiziano , Xu Yingxuan , Zhang Yang 
Published: August 2024

Abstract
We compute three families of two-loop six-point massless Feynman integrals in dimensional regularization, namely the double-box, the pentagon-triangle, and the hegaxon-bubble family. This constitutes the first analytic computation of two-loop master integrals with eight scales. We use the method of canonical differential equations. We describe the corresponding integral basis with uniform transcendentality, the relevant function alphabet, and analytic boundary values at a particular point in the Euclidean region up to the fourth order in the regularization parameter ϵ. The results are expressed as one-fold integrals over classical polylogarithms. We provide a set of supplementary files containing our results in machine-readable form, including a proof-of-concept implementation for numerical evaluations of the one-fold integrals valid within a subset of the Euclidean region.
Out-of-time-order asymptotic observables are quasi-isomorphic to time-ordered amplitudes
Authors: Borsten Leron , Jonsson D. Simon H. , Kim Hyungrok 
Published: August 2024

Abstract
Asymptotic observables in quantum field theory beyond the familiar S-matrix have recently attracted much interest, for instance in the context of gravity waveforms. Such observables can be understood in terms of Schwinger-Keldysh-type ‘amplitudes’ computed by a set of modified Feynman rules involving cut internal legs and external legs labelled by time-folds.In parallel, a homotopy-algebraic understanding of perturbative quantum field theory has emerged in recent years. In particular, passing through homotopy transfer, the S-matrix of a perturbative quantum field theory can be understood as the minimal model of an associated (quantum) L∞-algebra.Here we bring these two developments together. In particular, we show that Schwinger-Keldysh amplitudes are naturally encoded in an L∞-algebra, similar to ordinary scattering amplitudes. As before, they are computed via homotopy transfer, but using deformation-retract data that are not canonical (in contrast to the conventional S-matrix). We further show that the L∞-algebras encoding Schwinger-Keldysh amplitudes and ordinary amplitudes are quasi-isomorphic (meaning, in a suitable sense, equivalent). This entails a set of recursion relations that enable one to compute Schwinger-Keldysh amplitudes in terms of ordinary amplitudes or vice versa.
Runge–Kutta convolution quadrature based on Gauss methods
Authors: Banjai Lehel , Ferrari Matteo 
Published: August 2024

AbstractAn error analysis of Runge–Kutta convolution quadrature based on Gauss methods applied to hyperbolic operators is given. Order reduction is observed, with the order of convergence depending heavily on the parity of the number of stages, a more favourable situation arising for the odd cases than the even ones. An exception is observed when the associated kernel exhibits exponential decay. In this case, for the 2-stage Gauss method full order is obtained. For particular situations the order of convergence is higher than for Radau IIA or Lobatto IIIC methods when using the same number of odd stages. We investigate an application to transient acoustic scattering where, for certain scattering obstacles, the favourable situation occurs in the important case of the exterior Dirichlet-to-Neumann map. Numerical experiments and comparisons illustrate the performance of the method.
Application of chokeberry pomace as pectin substitute in nonconventional freeze-dried snacks: physicochemical characteristics of the products
Authors: Karwacka Magdalena , Galus Sabina , Janowicz Monika 
Published: August 2024

AbstractThe objective of the study was the development of nonconventional restructured freeze-dried multicomponent snacks obtained with the addition of chokeberry pomace powder (CP) supported by calcium ions (0, 0.01 and 0.05%). The study consisted of the evaluation of the impact of various quantities (1, 3 and 5%) of dried chokeberry pomace powder on selected physicochemical characteristics compared to snacks structured by pectin (0.5 and 1.5%). The results showed that the application of CP caused a significant reduction in the snacks’ water content and activity, which could contribute to enhanced stability. Hygroscopic properties and porosity also decreased with increasing quantity of CP, which was a consequence of structural changes in the material. The CP addition elevated the hardness of the snacks, however the effect was notably lower than after pectin incorporation. The use of the CP promoted the bioactive compound content and antioxidant activity of the freeze-dried snack. Total phenolic and anthocyanin contents elevated with the increasing quantity of CP, also followed by antioxidant activity improvement. The introduction of anthocyanins, which are red colorants, also caused notable changes in the color of the products. Overall, the application of chokeberry pomace resulted in obtaining an innovative snack option characterized by fortified bioactive compounds content and antioxidant activity. However, more research is needed to optimize also nutritional characteristics of the products.
Antifungal characterizations of a novel endo-β-1,6-glucanase from Flavobacterium sp. NAU1659
Authors: Xie TingTing , Shen Jiming , Geng Zhitao , Wu Fan , Dong Yiwei , Cui Zhongli , Liang Yongheng , Ye Xianfeng 
Published: August 2024

Abstract
β-1,6-Glucan plays a crucial role in fungal cell walls by linking the outer layer of mannoproteins and the inner layer of β-1,3-glucan, contributing significantly to the maintenance of cell wall rigidity. Therefore, the hydrolysis of β-1,6-glucan by β-1,6-glucanase directly leads to the disintegration of the fungal cell wall. Here, a novel β-1,6-glucanase FlGlu30 was identified from the endophytic Flavobacterium sp. NAU1659 and heterologously expressed in Escherichia coli BL21 (DE3). The optimal reaction conditions of purified FlGlu30 were 50℃ and pH 6.0, resulting in a specific activity of 173.1 U/mg using pustulan as the substrate. The hydrolyzed products of FlGlu30 to pustulan were mainly gentianose within 1 h of reaction. With the extension of reaction time, gentianose was gradually hydrolyzed to glucose, indicating that FlGlu30 is an endo-β-1,6-glucanase. The germination of Magnaporthe oryzae Guy11 spores could not be inhibited by FlGlu30, but the appressorium formation of spores was completely inhibited under the concentration of 250.0 U/mL FlGlu30. The disruptions of cell wall and accumulation of intracellular reactive oxide species (ROS) were observed in FlGlu30-treated M. oryzae Guy11 cells, suggesting the significant importance of β-1,6-glucan as a potential antifungal target and the potential application of FlGlu30.

Key points
• β-1,6-Glucan is a key component maintaining the rigid structure of fungal cell wall.
• β-1,6-Glucanase is an antifungal protein with significant potential applications.
• FlGlu30 is the first reported β-1, 6-glucanase derived from Flavobacterium.
Vignette-based comparative analysis of ChatGPT and specialist treatment decisions for rheumatic patients: results of the Rheum2Guide study
Authors: Labinsky Hannah , Nagler Lea-Kristin , Krusche Martin , Griewing Sebastian , Aries Peer , Kroiß Anja , Strunz Patrick-Pascal , Kuhn Sebastian , Schmalzing Marc , Gernert Michael , Knitza Johannes 
Published: August 2024

Abstract
Background
The complex nature of rheumatic diseases poses considerable challenges for clinicians when developing individualized treatment plans. Large language models (LLMs) such as ChatGPT could enable treatment decision support.

Objective
To compare treatment plans generated by ChatGPT-3.5 and GPT-4 to those of a clinical rheumatology board (RB).

Design/methods
Fictional patient vignettes were created and GPT-3.5, GPT-4, and the RB were queried to provide respective first- and second-line treatment plans with underlying justifications. Four rheumatologists from different centers, blinded to the origin of treatment plans, selected the overall preferred treatment concept and assessed treatment plans’ safety, EULAR guideline adherence, medical adequacy, overall quality, justification of the treatment plans and their completeness as well as patient vignette difficulty using a 5-point Likert scale.

Results
20 fictional vignettes covering various rheumatic diseases and varying difficulty levels were assembled and a total of 160 ratings were assessed. In 68.8% (110/160) of cases, raters preferred the RB’s treatment plans over those generated by GPT-4 (16.3%; 26/160) and GPT-3.5 (15.0%; 24/160). GPT-4’s plans were chosen more frequently for first-line treatments compared to GPT-3.5. No significant safety differences were observed between RB and GPT-4’s first-line treatment plans. Rheumatologists’ plans received significantly higher ratings in guideline adherence, medical appropriateness, completeness and overall quality. Ratings did not correlate with the vignette difficulty. LLM-generated plans were notably longer and more detailed.

Conclusion
GPT-4 and GPT-3.5 generated safe, high-quality treatment plans for rheumatic diseases, demonstrating promise in clinical decision support. Future research should investigate detailed standardized prompts and the impact of LLM usage on clinical decisions.