bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenging the Conventional Treatment Initiation Paradigm: Early Detection of Irreversible Cellular Damage in Cardiac Biopsies of Fabry Disease Before the Formation of Gb3 Inclusion Bodies
Authors: Lee Chung-Lin , Chen Pei-Sin , Lu Yu-Ying , Chiang Yu-Ting , Yen Ching-Tzu , Huang Chun-Ying , Cheng Yen-Fu , Lin Hsiang-Yu , Chen Yun-Ru , Niu Dau-Ming 
Published: July 2024

AbstractBackground:Fabry disease (FD) is a lysosomal storage disorder impacting multiple organs, including the heart. We investigated whether early-stage globotriaosylceramide (Gb3) accumulation, before occurrence of inclusion bodies, could cause significant stress and irreversible damages of the cardiomyocytes in FD patients. To assess the cellular stress and irreversible damage of cardiomyocytes in FD during early-stage Gb3 accumulation before the occurrence of typical pathology.Methods:Immunofluorescent (IF) staining or Western blotting were performed on fibroblasts from FD patients and myocardial biopsies from G3Stg/GLAko mice and FD patients. Notably, all biopsies exhibited detectable Gb3 accumulation under IF but lacked typical FD (Gb3 inclusion body) pathology. Staining targeted nuclear factor-κB (NF-κB), interleukin-18 (IL-18), phospho-p42/44 mitogen-activated protein kinase (MAPK), and inducible nitric oxide synthase (iNOS) as inflammatory and oxidative stress markers. Alpha-smooth muscle actin (α-SMA) IF staining was conducted to detect myofibroblasts.Results:Fibroblasts from FD patients, in conjunction with cardiomyocytes from both G3Stg/GLAko mice and FD patients, exhibited significant accumulation of inflammatory markers such as NF-κB IL-18 and phospho-p42/44 MAPK, as well as the oxidative stress marker iNOS. Despite the absence of typical FD pathology, the presence of fibrosis was confirmed in myocardial biopsies from these patients through strong positive staining of α-SMA.Conclusions:Significant cellular stress and even irreversible damage may occur before the onset of typical pathological changes in cardiomyocytes of FD. Based on our findings, treatment should be initiated much earlier than we currently thought to prevent irreversible damage and improve the prognosis of FD patients.
Variants in Vitamin D-related Genes and Prostate Cancer Risk in Black Men
Authors: Layne Tracy M. , Rothstein Joseph H. , Song Xiaoyu , Andersen Shaneda Warren , Benn Emma K.T. , Sieh Weiva , Klein Robert J. 
Published: July 2024

ABSTRACTBACKGROUNDThe relationship between vitamin D and prostate cancer has primarily been characterized among White men. However, Black men have higher prostate cancer incidence and mortality rates, chronically low circulating vitamin D levels, and ancestry-specific genetic variants in vitamin D-related genes. Here, we examine six critical genes in the vitamin D pathway and prostate cancer risk in Black men.METHODSWe assessed a total of 69 candidate variants in six genes (GC, CYP27A1, CYP27B1, CYP24A1, VDR, andRXRA) including functional variants previously associated with prostate cancer and circulating 25(OHD) in White men. Associations with prostate cancer risk were examined using genome-wide association study data for approximately 10,000 prostate cancer cases and 10,000 controls among Black men and over 85,000 cases and 91,000 controls among White men. A statistical significance threshold of 0.000724 was used to account for the 69 variants tested.RESULTSNone of the variants examined were significantly associated with prostate cancer risk among Black men after multiple comparison adjustment. Four variants tested P<0.05 in Black men, including two inRXRA(rs41400444 OR=1.09, 95% CI: 1.01-1.17,P= 0.024 and rs10881574 OR = 0.93, 0.87-1.00,P= 0.046) and two inVDR(rs2853563 OR = 1.07, 1.01-1.13,P= 0.017 and rs1156882 OR = 1.06, 1.00-1.12,P= 0.045). Two variants inVDRwere also positively associated with risk in White men (rs11568820 OR = 1.04, 1.02-1.06,P= 0.00024 and rs4516035 OR = 1.03, 1.01-1.04,P= 0.00055).CONCLUSIONWe observed suggestive non-significant associations between genetic variants inRXRAandVDRand prostate cancer risk in Black men. Future research exploring the relationship of vitamin D with cancer risk in Black men will need larger sample sizes to identify ancestry-specific variants relevant to risk in this population.
Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells
Authors: Moerkens Renée , Mooiweer Joram , Smits Eline , Berg Marijn , Ramírez-Sánchez Aarón D. , Modderman Rutger , Puschhof Jens , Pleguezuelos-Manzano Cayetano , Barrett Robert J. , Wijmenga Cisca , Jonkers Iris H. , Withoff Sebo 
Published: July 2024

AbstractThe human intestinal epithelial barrier is shaped by various biological and biomechanical influences such as growth factor gradients and the flow of intestinal contents. Exposure to these cuesin vitroimpacts the cell type composition and function of adult stem cell (ASC)-derived intestinal epithelial cells, but their effect on human induced pluripotent stem cell (hiPSC)-derived cells is largely unexplored. Here, we characterize and compare the cellular composition and gene expression profiles of hiPSC-derived intestinal epithelial cells exposed to various medium compositions and cultured as organoids, in Transwell and in microfluidic intestine-on-chip systems. We demonstrate that inhibition and activation of the WNT, BMP, NOTCH and MAPK pathways regulates the presence of dividing, absorptive and secretory epithelial lineages within these systems, as has been described for ASC-based systems. Upon differentiation, intestinal epithelial organoids and monolayers in Transwell systems expressed genes involved in important intestinal functions, including digestive enzymes, nutrient transporters and members of the Cytochrome P450 family implicated in drug metabolism. However, the dynamic microenvironment of the intestine-on-chip system induced the strongest upregulation of these genes, with an expression profile that suggests a more mature developmental state. Overall, these results underscore the value of hiPSC-derived intestinal epithelial cells for modeling important functions of the human intestinal epithelial barrier and facilitates the selection of relevant culture conditions for specific applications.
Phosphorylation-induced flexibility of proto-oncogenic Bcl3 regulates transcriptional activation by NF-κB p52 homodimer
Authors: Pan Wenfei , Biswas Tapan , Shahabi Shandy , Suryajaya William , Vasquez Andres , Du Qian , Ghosh Gourisankar , Wang Vivien Ya-fan 
Published: July 2024

AbstractB cell lymphoma 3 (Bcl3), a member of the IκB family proteins, modulates transcription by primarily associating with NF-κB p50 and p52 homodimers. Bcl3 undergoes extensive phosphorylation, though the functions of many of these modifications remain unclear. We previously described that phosphorylation at Ser33, Ser114 and Ser446 partially switches Bcl3 from acting as an IκB-like inhibitor to a transcription regulator by associating with the (p52:p52):DNA binary complex. Here, we identified another critical phosphorylation site, Ser366. Substituting at all four residues to phospho-mimetic glutamate further enhances Bcl3’s transcriptional activity. Phospho-modifications retain Bcl3’s ability to stably bind p52 but induces reciprocal structural changes as revealed by HDX-MS experiments; the N-terminal region stiffens, while the C-terminus becomes more flexible. The increased flexibility allowed the Bcl3:(p52p52) binary complex to better accommodate DNA. The removal of the C-terminal 28-residues transformed Bcl3 into a transcriptional activator independent of phosphorylation. Notably, most identified mutations in Bcl3 from various cancers map to its C-terminus, suggesting the functional relevance of Bcl3 C-terminal structural flexibility and enhanced interaction with (p52p52):DNA complex to transcriptional potential and disease. Overall, this study uncovers the mechanistic basis by which phosphorylation-driven structural changes convert Bcl3 from an inhibitor to a transcriptional cofactor of NF-κB, and how deregulation of its activity through altered phosphorylation or mutation can lead to cancer.
Transcriptional noise sets fundamental limits to spatially resolved cell-state decoding of the circadian clock
Authors: Nikhat Anjoom , Mandal Taniya , Veerasubramanian Nivedha , Chakrabarti Shaon 
Published: July 2024

AbstractCell-state discovery at single-cell resolution is currently a major endeavor of modern biology. While immense effort has gone into dealing with associated technical noise, there is little appreciation of the fundamental limits imposed by intrinsic biological stochasticity. Using the circadian clock as an example where true cell-states can be precisely defined (the oscillator phase), we study how bursty transcription limits the achievable cellular and spatial resolution of circadian-phase inference. Combining multiplexed smFISH to measure endogenous gene-expression and a novel supervised learning algorithm, we demonstrate how accurate inference is possible using just 3 genes but only after averaging over 20-70 cells. Commonly used algorithms generate single-cell clusters completely different from the true states, successfully recovering them only after averaging. Further, by decoding all states within a population of asynchronized cells, we demonstrate how coarse-graining provides a principled approach to spatially-resolved phase inference. Our results argue that coarse-graining is likely essential for meaningful cell-state assignment across biological systems, even when technical noise is minimized.
Electronic structure and resonant inelastic x-ray scattering in
Ca3Ru2O7
Authors: Antonov V. N. , Kukusta D. A. , Bekenov L. V. 
Published: July 2024

We have investigated the electronic structure of the transition metal oxide Ca3Ru2O7 within density-functional theory using the generalized gradient approximation while considering strong Coulomb correlations in the framework of the fully relativistic spin-polarized Dirac linear muffin-tin orbital band structure method. Ca3Ru2O7 can be classified as a Mott insulator since it was expected to be metallic from band structure calculations. We found that the magnetic ground state of Ca3Ru2O7 possesses an AFM−b magnetic structure with the Ru spin moments ordered antiferromagnetically along the b axis. We have investigated the resonant inelastic x-ray scattering (RIXS) spectra at the Ru and Ca K, L3, and M3 edges as well as at the OK edge. The experimentally measured RIXS spectrum of Ca3Ru2O7 at the Ru L3 edge possesses a sharp feature ≤2eV corresponding to transitions within the Ru t2g levels. The excitation located from 2 to 4 eV is due to t2g→ eg transitions. The third wide structure situated at 4.5−11eV appears due to transitions between the Ru 4dO states derived from the tails of oxygen 2p states and eg and t2g states. The RIXS spectra at the Ru L3 and M3 edges are quite similar. However, the corresponding RIXS spectra at the Ca site are quite different from each other due to the significant difference in the widths of core levels. The RIXS spectrum at the OK edge consists of three major inelastic excitations. We found that the first two low energy features ≤2.5eV are due to interband transitions between occupied and empty Ot2g states which appear due to the strong hybridization between oxygen 2p and Ru t2g states in close vicinity to the Fermi level. The next major peak between 2.5 and 8 eV reflects interband transitions from occupied O2p to empty Ot2g states. A wide energy interval between 4 and 11 eV is occupied by rather weak O2p→Oeg transitions.

Published by the American Physical Society
2024
Optimization on frequency constraints with FFT using automatic differentiation on hybrid ODE applications
Authors: Agobert Lucas , Delinchant Benoit , Gerbaud Laurent 
Published: July 2024

Purpose
This study aims to optimize electrical systems represented by ordinary differential equations and events, using their frequency spectrum is an important purpose for designers, especially to calculate harmonics.

Design/methodology/approach
This paper presents a methodology to achieve this, by using a gradient-based optimization algorithm. The paper proposes to use a time simulation of the electrical system, and then to compute its frequency spectrum in the optimization loop.

Findings
The paper shows how to proceed efficiently to compute the frequency spectrum of an electrical system to include it in an optimization loop. Derivatives of the frequency spectrum such as the optimization inputs can also be calculated. This is possible even if the sized system behavior cannot be defined a priori, e.g. when there are static converters or electrical devices with natural switching.

Originality/value
Using an efficient sequential quadratic programming optimizer, automatic differentiation is used to compute the model gradients. Frequency spectrum derivatives with respect to the optimization inputs are calculated by an analytical formula. The methodology uses a “white-box” approach so that automatic differentiation and the differential equations simulator can be used, unlike most state-of-the-art simulators.
Job advertisements and lived experiences of victims of job scams in Ibadan, Nigeria
Authors: Obuene Henry Uche , Tade Oludayo , Rasak Bamidele , Arisukwu Ogadimma , Okafor Emeka E. 
Published: July 2024

PurposeAn increase in informal job advertisements has been attributed to high unemployment. However, less scholarly attention has been placed on the experiences of victims of advertised job scams.Design/methodology/approachThis explorative study investigates the lived experiences of victims of advertised job scams in Ibadan, Oyo State, Nigeria, adopting Durkheim’s Functionalism and Anomie Theory. Around 35 victims were purposively engaged in in-depth and telephone interviews.FindingsThe findings of the study indicated the link between functionalism and anomie, an increasing rate of advertised job scams and a high rate of unemployment and poverty as well as the desperation of victims in getting jobs. The value orientation of an individual is determined by the dynamics of the social institutions. The pattern of job scammers revealed extremists conditioned by the large number of youths seeking employment. The advertised scam jobs are usually unavailable. In addition, employers, through informal job advertisements, subject victims to extortions, exploitation, street begging, kidnapping and rituals as well as sexual harassment and rape. Owing to the high rate of unemployment, many genuine job offers are characterised by bribes, besides trivializing merit.Originality/valueThe government should design measures to tackle the rate of corruption and unemployment. This can be achieved by introducing entrepreneurship and skill acquisition programmes in the nation’s education system.
Gold characteristics as safe haven and assets diversification for Sharia stocks in Indonesia
Authors: Rusmita Sylva Alif , Filianti Dian , Mayasani Ega Nuriayu , Samad Khairunnisa Abd 
Published: July 2024

Purpose
This study aims to determine the role of gold as a safe haven, hedge and asset diversification for Shariah stock in conditions of extreme stock market declines.

Design/methodology/approach
Quantitative approach is used by applying the threshold generalized autoregressive conditional heteroskedasticity (TGARCH) model to capture bad or good news in the market condition and quantile regression method to obtain the extreme values of stock returns in several market conditions. The data used were the daily closing price of gold and the Jakarta Islamic Index from January 2011 to October 2022.

Findings
The average conditions show gold does not have a hedge property and only acts as an asset diversification. Second, gold has a substantial, safe haven property in every economic condition. However, the safe-haven property of gold seemed to weaken during the most extreme stock market decline. Thus, although gold appears as a safe haven and asset diversification, it remains a risky investment and only provides a minor role in the face of the extreme stock market period.

Practical implications
This research provides a discourse and literature for Islamic investors and investor managers to choose the right investment instrument in various economic conditions where gold has a function as diversification and safe haven in their asset portfolio under any other asset portfolio conditions which is also in line with modern portfolio theory. For policymakers, the study can be used as material for consideration in making policies related to the accessibility of gold as an investment instrument.

Originality/value
This study presents the originality by using the price of Antam gold as a proxy for gold investment during the latest research year data and focusing on case studies in Islamic capital market in Indonesia. Moreover, this research provides quantile regression that sharply discussion in various economics condition.
Librarians as guardians of information quality: navigating the challenges of misinformation and disinformation
Authors: Adewojo Akinade Adebowale , Esan Adedoyin Oluwatosin , Aleem Abdulmalik Oyindamola 
Published: July 2024

Purpose
This study aims to explore the pivotal role of libraries in combating misinformation and disinformation in the contemporary information landscape, emphasizing their significance as guardians of information integrity.

Design/methodology/approach
Drawing on a review of literature and surveying librarian perspectives, this study examines the multifaceted strategies used by libraries to address misinformation and disinformation. It delves into the roles of librarians in distinguishing between different forms of false information, promoting information literacy and fostering community engagement.

Findings
Libraries serve as bastions of knowledge, curating diverse and reliable resources while actively combating false information through educational initiatives, technological innovations and community outreach. Librarians play a crucial role in empowering users with the skills to critically evaluate information and navigate the complexities of the digital age.

Originality/value
This study contributes to the scholarly discourse by highlighting the evolving role of libraries as guardians of information integrity in the face of misinformation and disinformation. It underscores the importance of libraries in promoting a more informed and resilient society, enriching public discourse with the values of truth and understanding.
Does self-sacrificial leadership reduce the subordinate’s organizational cynicism? The mediating role of distributive justice and ethical corporate social responsibility
Authors: Yan Dong , Li Longzhen , Jeon Hyangsuk 
Published: July 2024

PurposeAlthough self-sacrificial leadership and ethical leadership exhibit similarities in their moral dimensions, recent research suggests that self-sacrificial leadership may be linked to an increase in unethical behavior for the collective benefit of one’s group. Existing studies have demonstrated that ethical leadership can mitigate organizational cynicism. However, the potential misalignment between group interests and ethics associated with self-sacrificial leadership raises concerns about its potential to foster cynicism. This study investigates the mechanisms by which self-sacrificial leadership influences organizational cynicism.Design/methodology/approachSurvey data from 493 organizational members across 9 Chinese companies were analyzed using multiple regression analysis, and bootstrapping was employed to confirm the mediating effects.FindingsSelf-sacrificial leadership was found to have an overall reducing effect on organizational cynicism, with distributive justice and ethical CSR perceptions as significant mediating factors.Originality/valueThis study sheds light on the unique characteristics of self-sacrificial leadership, highlighting the elements of sacrifice and loyalty that may result in unethical, self-centered behaviors, and explores its influence on organizational cynicism. By revealing that the recognition of augmented group interests can diminish cynicism among organizational members regardless of morality, this study contributes to broadening the theoretical perspective.
Evaluating the financial reporting quality under changes in accounting standards of the Indian textile sector
Authors: Shayf Abdulfatah Abdullah Abdulkareem , Abdullah Mohd , Tabash Mosab I. , Saleem Shahrukh , Chaudhary Asiya , Ali Ammar , Shamsi Mushahid Ali 
Published: July 2024

Purpose
The study evaluates whether an application of Ind-AS that converged with IFRS in India has enhanced financial reporting quality (FRQ) and how that is reflected in financial performance (FP).

Design/methodology/approach
Design/methodology/approach: The study uses discretionary accruals (DACC) to measure FRQ. In addition, it uses ordinary least square (OLS) regression to examine the association between Corporate Governance attributes, FRQ, and financial performance for a sample of 24 textile companies from 2010 to 2021.

Findings
The results indicate that adopting IFRS has a role in monitoring CG attributes to enhance FRQ; this means the financial reporting qualit improves somewhat with some CG attributes under Ind-AS. In addition, the results demonstrate that financial reporting quality positively influences FP.

Practical implications
There are significant effects on authorities and decision-makers. The findings from this research can benefit lawmakers by providing Ind-AS policy enforcement with more consideration. The results are also helpful for policymakers who want to improve CG and need proof of the significance of high FRQ in this respect.

Originality/value
Given the dearth of research on FRQ in India, the study extends prior literature on FRQ by examining the quality of financial reporting according to the transformation to IFRS in Indian textile firms. The theoretical contribution of the current study is the testing of agency theory towards practices of corporate governance mechanisms on FRQ and FP in the context of the textile sector.
CSR research in the hotel industry: how it relates to promoting the SDGs
Authors: Moyeen Abdul , Mehjabeen Melita 
Published: July 2024

Purpose
Research suggests the hotel industry has grown to integrate corporate social responsibility (CSR) programs towards addressing issues relating to the sustainable development goals (SDGs). Nevertheless, how the progression of research has influenced the field of CSR and the SDGs remains unexplored. This paper aims to address the knowledge gap.

Design/methodology/approach
The research is based on a review of 230 papers from Scopus Indexed Journals – both mainstream and specialty. A content analysis was conducted to identify the major themes and the evolution of CSR research in the hotel industry.

Findings
Recent CSR research has tended to shift towards issues such as CSR communication and reporting from its earlier focus on the perceptions and practices of CSR. The SDGs, in general, and environmental sustainability, in particular, remain on the periphery of hotel industry’s CSR initiatives. This raises concern about the ability of CSR programs to facilitate the SDGs by 2030. This study highlights that both stakeholders (e.g. consumers, employees) and business forces (e.g. financial bottom line) can shape the hotel industry’s CSR strategies in contributing to the SDGs and greater sustainability.

Originality/value
The research advances the CSR and sustainability literature by undertaking a comprehensive review of business research on CSR in the hotel industry focusing on the SDGs, and advancing and facilitating discussion on existing knowledge in this field and how the field can be further developed.