bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospect for future MeV gamma-ray active galactic nuclei population studies
Authors: Inoue Yoshiyuki , Tanaka Yasuyuki T. , Odaka Hirokazu , Takada Atsushi , Ichinohe Yuto , Saito Shinya , Takeda Shin'ichiro , Takahashi Tadayuki 
Published: June 2015

Abstract
While the X-ray, GeV gamma-ray, and TeV gamma-ray skies have been extensively studied, the MeV gamma-ray sky has not yet been well investigated since the Imaging Compton Telescope (COMPTEL) scanned the sky about two decades ago. In this paper, we investigate the prospects for active galactic nuclei population studies with future MeV gamma-ray missions using recent spectral models and luminosity functions of Seyferts and flat-spectrum radio quasars (FSRQs). Both of them are plausible candidates for the origins of the cosmic MeV gamma-ray background. If the cosmic MeV gamma-ray background radiation is dominated by non-thermal emission from Seyferts, a sensitivity of 10−12 erg cm−2 s−1 is required to detect several hundred Seyferts in the entire sky. If FSRQs make up the cosmic MeV gamma-ray background, a sensitivity of ∼ 4 × 10−12 erg cm−2 s−1 is required to detect several hundred FSRQs following the recent FSRQ X-ray luminosity function. However, based on the latest FSRQ gamma-ray luminosity function, with which FSRQs can explain up to ∼ 30% of the MeV background, we can expect several hundred FSRQs even with a sensitivity of 10−11 erg cm−2 s−1, which is almost the same as the sensitivity goal of the next-generation MeV telescopes.
Evaluation of a New Software Version of the RTVue Optical Coherence Tomograph for Image Segmentation and Detection of Glaucoma in High Myopia
Authors: Holló Gábor , Shu-wei Hsu , Naghizadeh Farzaneh 
Published: June 2015

Purpose:
To compare the current (6.3) and a novel software version (6.12) of the RTVue-100 optical coherence tomograph (RTVue-OCT) for ganglion cell complex (GCC) and retinal nerve fiber layer thickness (RNFLT) image segmentation and detection of glaucoma in high myopia.

Materials and Methods:
RNFLT and GCC scans were acquired with software version 6.3 of the RTVue-OCT on 51 highly myopic eyes (spherical refractive error ≤−6.0 D) of 51 patients, and were analyzed with both the software versions. Twenty-two eyes were nonglaucomatous, 13 were ocular hypertensive and 16 eyes had glaucoma.

Results:
No difference was seen for any RNFLT, and average GCC parameter between the software versions (paired t test, P≥0.084). Global loss volume was significantly lower (more normal) with version 6.12 than with version 6.3 (Wilcoxon signed-rank test, P<0.001). The percentage agreement (κ) between the clinical (normal and ocular hypertensive vs. glaucoma) and the software-provided classifications (normal and borderline vs. outside normal limits) were 0.3219 and 0.4442 for average RNFLT, and 0.2926 and 0.4977 for average GCC with versions 1 and 2, respectively (McNemar symmetry test, P≥0.289). No difference in average RNFLT and GCC classification (McNemar symmetry test, P≥0.727) and the number of eyes with at least 1 segmentation error (P≥0.109) was found between the software versions, respectively.

Conclusion:
Although GCC segmentation was improved with software version 6.12 compared with the current version in highly myopic eyes, this did not result in a significant change of the average RNFLT and GCC values, and did not significantly improve the software-provided classification for glaucoma.
The migration game in habitat network: the case of tuna
Authors: Mariani Patrizio , Křivan Vlastimil , MacKenzie Brian R , Mullon Christian 
Published: June 2015

AbstractLong distance migration is a widespread process evolved independently in several animal groups in terrestrial and marine ecosystems. Many factors contribute to the migration process and of primary importance are intra-specific competition and seasonality in the resource distribution. Adaptive migration in direction of increasing fitness should leads to the ideal free distribution (IFD) which is the evolutionary stable strategy of the habitat selection game. We introduce a migration game which focuses on migrating dynamics that lead to the IFD for age-structured populations in time varying environments where dispersal is costly. The model assumes a network of habitats and predicts migration dynamics between these habitats and the corresponding population distribution. When applied to Atlantic bluefin tunas it predicts their migration routes and their seasonal distribution. The largest biomass is located in the spawning areas which have also the largest diversity in the age-structure. Distant feeding areas are occupied on a seasonal base and often by larger individuals, in agreement with empirical observation. Moreover we show that only a selected number of migratory routes emerge as those effectively used by tunas.
Effect of organizational factors on employees’ generation of innovative ideas
Authors: Abdel Aziz Hadia Hamdy , Rizkallah Ashraf 
Published: June 2015

Purpose
– The purpose of this paper is to measure the relationship between the organizational factors that affect innovation performance and the idea generation of employees. Factors examined include: appropriate use of rewards inside the organization, management support for developing new ideas, the tolerance in accepting failures and taking risks, allocation of resources and specially the free time, and finally the organizational structure and the related centralization of decision making.

Design/methodology/approach
– The purpose of the study is achieved through an empirical quantitative study on the software development industry of Egypt.

Findings
– Results indicate that, while all factors proved to be significantly correlated with employees’ innovative ideas generation; the availability of innovation based rewards, action based managerial support and decentralized decision making proved to be the most important factors contributing to the increase of innovation ideas generated and shared by employees. Results also indicate that managers and leaders generate more ideas than junior employees.

Originality/value
– Understanding the organizational factors that contribute to the employee’s generation of innovative ideas enables organizations to adapt their practices towards maximizing the contribution of their employees to more successful organizational innovation.
Numerical simulation of Nusselt-Rayleigh correlation in Bénard cells. A solution based on the network simulation method
Authors: Cánovas Manuel , Alhama Iván , Trigueros Emilio , Alhama Francisco 
Published: June 2015

Purpose
– Natural convection with heat transfer in porous media has been subject of extensive study in engineering due to its numerous applications. A case of particular interest is the Bénard-type flow.The paper aims to discuss this issue.

Design/methodology/approach
– Based on the network simulation method in order to solve this problem, a numerical model is proposed.

Findings
– Nusselt-Rayleigh correlation is determined for a broad range of Rayleigh, the dimensionless number that influences the solution, above and below the threshold which separates the conduction and convection pure mechanisms.

Originality/value
– Based on the network simulation method.
Morning in refugee health: an introduction for medical students
Authors: Duke Pauline S. , Brunger Fern , Ohle Elizabeth 
Published: June 2015

Purpose
– Migration is increasing worldwide. health care practitioners must provide care to migrants in a culturally competent manner that is sensitive to cultural, political and economic contexts shaping health and illness. Many studies have provided strong evidence that health providers benefit from training in cross-cultural care. Cultural competence education of medical students during their early learning can begin to address attitudes and responsiveness toward refugees. At Memorial University in Canada, the authors designed “Morning in Refugee Health”, an innovative program in cultural competency training for first year medical students in the Clinical Skills and Ethics course. The purpose of this paper is to discuss these issues.

Design/methodology/approach
– Here the authors introduce the curriculum and provide the rationale for the specific pedagogical techniques employed, emphasizing the consideration of culture in its relation to political and economic contexts. The authors describe the innovation of training standardized patients (SPs) who are themselves immigrants or refugees. The authors explain how and why the collaboration of community agencies and medical school administration is key to the successful implementation of such a curriculum.

Findings
– Medical students benefit from early pre-clinical education in refugee health. Specific attention to community context, SP training, small group format, linkages between clinical skills and medical ethics, medical school administrative and community agency support are essential to development and delivery of this curriculum. As a result of the Morning in Refugee Health, students initiated a community medical outreach project for newly arriving refugees.

Originality/value
– The approach is unique in three ways: integration of training in clinical skills and ethics; training of SPs who are themselves immigrants or refugees; and reflection on the political, economic and cultural contexts shaping health and health care.
High PEEP levels are associated with overdistension and tidal recruitment/derecruitment in ARDS patients
Authors: Retamal J. , Bugedo G. , Larsson A. , Bruhn A. 
Published: June 2015

BackgroundPositive end‐expiratory pressure (PEEP) improves gas exchange and respiratory mechanics, and it may decrease tissue injury and inflammation. The mechanisms of this protective effect are not fully elucidated. Our aim was to determine the intrinsic effects of moderate and higher levels of PEEP on tidal recruitment/derecruitment, hyperinflation, and lung mechanics, in patients with acute respiratory distress syndrome (ARDS).MethodsNine patients with ARDS of mainly pulmonary origin were ventilated sequential and randomly using two levels of PEEP: 9 and 15 cmH2O, and studied with dynamic computed tomography at a fix transversal lung region. Tidal recruitment/derecruitment and hyperinflation were determined as non‐aerated tissue and hyperinflated tissue variation between inspiration and expiration, expressed as percentage of total weight. We also assessed the maximal amount of non‐aerated and hyperinflated tissue weight.ResultsPEEP 15 cmH2O was associated with decrease in non‐aerated tissue in all the patients (P < 0.01). However, PEEP 15 cmH2O did not decrease tidal recruitment/derecruitment compared to PEEP 9 cmH2O (P = 1). In addition, PEEP 15 cmH2O markedly increased maximal hyperinflation (P < 0.01) and tidal hyperinflation (P < 0.05). Lung compliance decreased with PEEP 15 cmH2O (P < 0.001).ConclusionIn this series of patients with ARDS of mainly pulmonary origin, application of high levels of PEEP did not decrease tidal recruitment/derecruitment, but instead consistently increased tidal and maximal hyperinflation.
Stage‐specific reference genes significant for quantitative PCR during mouse retinal development
Authors: Adachi Hiroko , Tominaga Hiroyuki , Maruyama Yuko , Yoneda Kazuhito , Maruyama Kazuichi , Yoshii Kengo , Kinoshita Shigeru , Nakano Masakazu , Tashiro Kei 
Published: June 2015

Developing mouse retina has been serving as an ideal model for investigating the molecular mechanism of neural development and angiogenesis, because several significant events associated with these physiological phenomena are drastically occurring in conjunction with retinal development. However, as many genes are influencing on each other to establish mature retina within 21 days from E10 to P12, we must carefully design the experiments, such as in the case of quantitating the amount of altered gene expression toward the establishment of retina by quantitative PCR. As we have seen considerable variations of quantitative results in different developmental stages of retina depending on the reference genes used for compensation, we here attempted to determine a reliable reference gene to accurately quantitate the target genes in each stage. According to the results of in silico prediction and comparison with a database of SAGE, we found that the most stable gene from early to late stages was Sdha, whereas one of the most popular housekeeping genes, Actb, was the one that could mislead the quantitative results even in the adult stage. Consequently, we pointed out the importance of selecting an appropriate reference gene, especially to quantitate the amount of gene expression in the developmental stages of a certain tissue.
Assessing effective population size, coancestry and inbreeding effects on litter size using the pedigree and SNP data in closed lines of the Iberian pig breed
Authors: Silió L. , Barragán C. , Fernández A.I. , García‐Casco J. , Rodríguez M.C. 
Published: June 2015

SummaryThe complete pedigree of two closed Iberian pig lines (Gamito and Torbiscal), with 798 and 4077 reproducers, has been used to measure the evolution of coancestry (f) and inbreeding (F) for autosomal and X‐linked genes along 16 and 28 respective equivalent discrete generations. At the last generation, the mean values of each line were f = 0.41 and 0.22, F = 0.35 and 0.18, fX = 0.46 and 0.22 and FX = 0.47 and 0.19, respectively. Other calculated parameters were the effective number of founders (final values, 6.8 and 35.2) and non‐founders (1.5 and 2.4), founder genome equivalents (1.2 and 2.3) and effective population size (16.0 and 57.7). Measures of Torbiscal effective size based on rates of coancestry (66.1), inbreeding (65.0) and linkage disequilibrium (71.0) were estimated from whole‐genome SNP genotyping data. Values of new and old inbreeding and their respective rates by generation were computed to detect purging effects of natural selection. The analysis of 6854 Torbiscal litters showed significant negative impacts of new and fast inbreeding on litter size, as expected from the purging hypothesis: −0.20 born piglets per litter by a 10% of new inbreeding, and −0.03 and −0.02 piglets by 1% of total and new inbreeding rates, respectively. The analysis performed on 1274 litters of the Gamito line failed to show purging effects. The only significant results were reductions in −0.91 and −0.17 piglets by a 10% of old and X‐linked genes inbreeding, respectively. These results may be useful for some practical issues in conservation programs of farm or captive wild animals.
Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancer
Authors: Mi J.‐Q. , Chen S.‐J. , Zhou G.‐B. , Yan X.‐J. , Chen Z. 
Published: June 2015

AbstractAcute promyelocytic leukaemia (APL), the M3 subtype of acute myeloid leukaemia, was once a lethal disease, yet nowadays the majority of patients with APL can be successfully cured by molecularly targeted therapy. This dramatic improvement in the survival rate is an example of the advantage of modern medicine. APL is characterized by a balanced reciprocal chromosomal translocation fusing the promyelocytic leukaemia (PML) gene on chromosome 15 with the retinoic acid receptor α (RARα) gene on chromosome 17. It has been found that all‐trans‐retinoic acid (ATRA) or arsenic trioxide (ATO) alone exerts therapeutic effect on APL patients with the PML‐RARα fusion gene, and the combination of both drugs can act synergistically to further enhance the cure rate of the patients. Here, we provide an insight into the pathogenesis of APL and the mechanisms underlying the respective roles of ATRA and ATO. In addition, treatments that lead to more effective differentiation and apoptosis of APL cells, including leukaemia‐initiating cells, and more thorough eradication of the disease will be discussed. Moreover, as a model of translational research, the development of a cure for APL has followed a bidirectional approach of ‘bench to bedside’ and ‘bedside to bench’, which can serve as a valuable example for the diagnosis and treatment of other malignancies.
Agreement between clinical and portable EMG/ECG diagnosis of sleep bruxism
Authors: Castroflorio T. , Bargellini A. , Rossini G. , Cugliari G. , Deregibus A. , Manfredini D. 
Published: June 2015

SummaryThe aim of this study was to compare clinical sleep bruxism (SB) diagnosis with an instrumental diagnosis obtained with a device providing electromyography/electrocardiography (EMG/ECG) recordings. Forty‐five (N = 45) subjects (19 males and 26 females, mean age 28 ± 11 years) were selected among patients referring to the Gnathology Unit of the Dental School of the University of Torino. An expert clinician assessed the presence of SB based on the presence of one or more signs/symptoms (i.e. transient jaw muscle pain in the morning, muscle fatigue at awakening, presence of tooth wear, masseter hypertrophy). Furthermore, all participants underwent an instrumental recording at home with a portable device (Bruxoff®; OT Bioelettronica, Torino, Italy) allowing a simultaneous recording of EMG signals from both the masseter muscles as well as heart frequency. Statistical procedures were performed with the software Statistical Package for the Social Science v. 20.0 (SPSS 20.0®; IBM, Milan, Italy). Based on the EMG/ECG analysis, 26 subjects (11 males, 15 females, mean age 28 ± 10 years) were diagnosed as sleep bruxers, whilst 19 subjects (7 males, 12 females, mean age 30 ± 10 years) were diagnosed as non‐bruxers. The correlation between the clinical and EMG/ECG SB diagnoses was low (ϕ value = 0·250), with a 62·2% agreement (28/45 subjects) between the two approaches (kappa = 0·248). Assuming instrumental EMG/ECG diagnosis as the standard of reference for definite SB diagnosis in this investigation, the false‐positive and false‐negative rates were unacceptable for all clinical signs/symptoms. In conclusion, findings from clinical assessment are not related with SB diagnosis performed with a portable EMG/ECG recorder.
Improved genetic counseling in Alport syndrome by new variants of COL4A5 gene
Authors: Fernandez‐Rosado Francisco , Campos Ana , Alvarez‐Cubero Maria Jesus , Ruiz Ana , Entrala‐Bernal Carmen 
Published: June 2015

AbstractThere are current requirements of using genetic databases for offering a better genetic assistance to patients of some syndromes, especially those with X‐linked heredity patterns (like Alport Syndrome) for the high probability of having descendants affected by the disease. We describe the first reported case of COL4A5 gene missense c.1499 G > T mutation in a 16‐year‐old girl confirmed to be affected by Alport Syndrome after genetic counseling. Next Generation Sequencing procedures let discover this mutation and offer an accurate clinical treatment to this patient. Current scientific understanding of genetic syndromes suggests the high importance of updated databases and the inclusion of Variant of Unknown Significance related to clinical cases. All of this updating could enable patients to have a better opportunity of diagnosis and having genetic and clinical counseling. This event is even more important in women planning to start a family to have correct genetic counseling regarding the risk posed to offspring, and allowing the decision to undergo prenatal testing.
Barley Ant1 is a homolog of maize C1 and its product is part of the regulatory machinery governing anthocyanin synthesis in the leaf sheath
Authors: Shoeva Olesya Y. , Kukoeva Tatyana V. , Börner Andreas , Khlestkina Elena K. 
Published: June 2015

AbstractAnthocyanins contribute to plants’ defence against a number of abiotic and biotic stress agents. The anthocyanin pigmentation of the barley leaf sheath is genetically determined by Ant1, a gene which maps to a region of chromosome 7HS delimited by the microsatellite loci Xgbms0226 and Xgbms0240. The sequence of the maize gene C1 (encoding an R2R3 MYB factor regulating anthocyanin synthesis) was used for the PCR‐based cloning of Ant1. In ant1 genotypes, no transcript is generated in the leaf sheath, whereas the gene is active in the presence of the dominant allele. A comparison of the coding and promoter sequences of Ant1 (which induces purple pigmentation in the leaf sheath) and ant1 (which does not) showed that the key polymorphisms lay in the promoter sequence. The transcription of four anthocyanin synthesis structural genes (Chi, F3h, Dfr, Ans) was dependent on the allelic status of Ant1.
De novo development of antibodies to kidney‐associated self‐antigens angiotensin II receptor type I, collagen IV, and fibronectin occurs at early time points after kidney transplantation in children
Authors: Hesemann Laura E. , Subramanian Vijay , Mohanakumar Thalachallour , Dharnidharka Vikas R. 
Published: June 2015

AbstractChronic rejection is the leading cause of graft loss following pediatric kidney transplantation. Our group and others have demonstrated an association between the development of Abs to self‐antigens and chronic rejection following adult lung and heart transplantation. The goal of this study was to determine whether Abs to kidney‐associated self‐antigens develop following pediatric renal transplantation. We investigated post‐transplant development of Abs to kidney‐associated self‐antigens angiotensin II receptor type I, Fn, and collagen IV in a pediatric cohort. Using ELISA, we measured Abs to kidney‐associated self‐antigens in serum. Our cohort included 29 subjects with samples collected pretransplant and for 12 months post‐transplant. No samples had Abs to kidney‐associated self‐antigen pretransplant. In contrast, 50% (10/20) of subjects developed Abs to one or more kidney‐associated self‐antigen post‐transplantation. The median time to antibody appearance and duration of persistence were 103 and 61 days, respectively. Development of Abs did not correlate with graft function. Half of subjects developed Abs to kidney‐associated self‐antigens angiotensin II receptor type I, Fn, or collagen IV in the first year after kidney transplantation—a higher rate of early antibody development than expected. In this small study, Abs did not correlate with worse clinical outcomes.
Size does matter! Perceptual stimulus properties affect event‐related potentials during feedback processing
Authors: Pfabigan Daniela M. , Sailer Uta , Lamm Claus 
Published: June 2015

AbstractThe current study investigated whether or not the physical aspect of stimulus size has an effect on neuronal correlates of feedback processing. A time estimation task was administered applying three different feedback stimulus categories: small, middle, and large size stimuli. Apart from early visual ERPs such as P1 and N1 components, later feedback processing stages were also affected by the size of feedback stimuli. In particular, small size stimuli compared to middle and large size ones led to diminished amplitudes in both FRN and P300 components, despite intact discrimination between negative and positive outcomes in these two ERPs. In contrast, time estimation performance was not influenced by feedback size. The current results indicate that small size feedback stimuli were perceived as less salient and hence were processed less deeply than the others. This suggests that future feedback studies could manipulate feedback salience simply by presenting differently sized feedback stimuli, at least when the focus lies on FRN and P300 amplitude variation.