bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infection with haemoplasma species in 22 cats with anaemia
Authors: Weingart Christiane , Tasker Séverine , Kohn Barbara 
Published: March 2015

Objectives Information regarding the clinical course of natural infection with feline haemotropic mycoplasmas (haemoplasmas) is limited. The objective of the study was to describe the clinical findings and course of disease in naturally infected cats with haemoplasmosis and anaemia. Methods A retrospective analysis was performed on patient data from cats presenting with anaemia and haemoplasma infection regarding signalment, clinical signs, laboratory data and course of infection. The diagnosis was confirmed by conventional haemoplasma PCR analysis. Results Haemoplasma infection was found in 22 anaemic (haematocrit 5–25% [median 17%]; reference interval 30–44%) cats (‘ Candidatus Mycoplasma haemominutum’, n = 12; Mycoplasma haemofelis, n = 3; ‘ Candidatus Mycoplasma turicensis’, n = 2; species not determined, n = 4; coinfection with all three species, n = 1) between 2005 and 2014. Thirteen of the cats had concurrent diseases. All cats underwent antibiotic treatment; 15 cats received blood products. Six cats were euthanased within 11 weeks owing to concurrent disease, persistent severe anaemia or financial constraints. Ten cats underwent follow-up for a period of 14–199 weeks (median 26 weeks). Haemoplasma PCR was negative in 5/7 cases after 3–23 weeks. PCR remained positive in two cases after 18 and 199 weeks, respectively. Reactivation of the haemoplasma infection occurred in two cats, once and three times, respectively, up to 177 weeks after initial presentation. Reactivation was suspected in two further cases. Owing to concurrent disease, four of the 10 follow-up cats were euthanased 14–180 weeks after initial presentation. Conclusion and relevance Infection with haemoplasma species is often chronic, can reactivate months later and is rarely a reason for euthanasia.
Heidegger, education, nation and race
Authors: Aboutorabi Rozita 
Published: March 2015

There are many arguments about Heidegger's work Being and Time (1954). Many critics believe that Heidegger provides a new way of understanding ourselves from a philosophical perspective. However, while some critics emphasize the de-Nazification of Heidegger's thinking, other still promote the notion that Being and Time is pro-Nazi. What is more, this new way of understanding brings a new challenge to education. In this paper, the concepts of Volk (people) and its relation with Being and Time is studied. Also, education is investigated in order to bring up authentic Dasein on Heidegger's view. The exploration undertaken in this paper illustrates that the concept of Volk is not, in Heidegger's view, related to the biological features of a race, but to the mood of attunement to Being, which itself is determined by its historicity and its capacity to bring about both differentiation and order. In general, Heidegger's interpretation of work is based on his concept of Dasein in the Being and Time and, as Radloff ((2007) Heidegger and the Question of National Socialism: Disclosure and Gestalt. Toronto: University of Toronto Press) believed, this is not tactical accommodation to Nazism. In Being and Time, Heidegger tries to save Dasein from everydayness and what he calls ‘the they’ by calling attention to be authentic. In Heidegger's (1985) view, the questioning process unlocks the essentials in things by forcing us to focus on what would seem to be simple and obvious. Also questioning Dasein’s beliefs and behaviours unfold the causes of them and is a way of bringing up an authentic Dasein and open-minded person. In order to achieve this, we need an authentic teacher who is not lost in ‘the they’. Hence, we might speculate that if schools follow Heidegger's thinking, they would be attractive places in which to provide situations for students to ask question and not be bored. Students are encouraged to learn while pursuing questions. They are active and eager learners who learn through rethinking matters, even if these matters are completely obvious. They learn about them in a manner that their thinking enters unconcealment. If this were the case, education might lead students to become more thoughtful.
Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis
Authors: Dun Jiening , Chen Xueyan , Gao Haixia , Zhang Yan , Zhang Huajun , Zhang Yongjian 
Published: March 2015

Many studies have shown that natural dietary agents, in combination with chemical agents, can improve the therapeutic response of cancers to chemotherapy and reduce the associated side-effects. In the present study, we investigated the therapeutic potential and mechanisms of anticancer effects for the combination of 5-fluorouracil (5-FU) and resveratrol (Res). In these studies, we employed the cancer cell lines TE-1 and A431 and an animal model of skin cancer. The presented results provide the first evidence that Res can enhance the anti-tumor potency of 5-FU by inducing S-phase arrest. The combination of Res and 5-FU demonstrates synergistic efficacy, causing tumor regression in a two-stage model of mouse skin carcinogenesis induced by DMBA and TPA. There was clear evidence of Res augmenting the growth inhibitory effect of 5-FU on the TE-1 and A431 cancer cells in vitro. In the in vivo studies, the tumor regression rate in the combination group increased significantly after four weeks of treatment ( P < 0.01). The combination of 5-FU and Res significantly increased the percentage of apoptotic cells and the level of activated caspase-3, cleaved PARP and p53 proteins as well as increased the Bax/Bcl-2 ratio. In conclusion, the 5-FU/Res combination enabled a more effective inhibition of cell growth and the induction of apoptosis in cancer cells than 5-FU alone. The results of this study suggest that chemotherapy using natural dietary agents with chemical agents represents a superior cancer treatment option.
Application of the Barcelona Clinic Liver Cancer therapeutic strategy and impact on survival
Authors: Hernández-Guerra Manuel , Hernández-Camba Alejandro , Turnes Juan , Ramos Luis Martin , Arranz Laura , Mera José , Crespo Javier , Quintero Enrique 
Published: March 2015

BackgroundThe Barcelona Clinic Liver Cancer (BCLC) classification of hepatocellular carcinoma (HCC) has proved useful in the management of HCC patients. However, BCLC‐recommended first‐line treatment is not always applicable in clinical practice.ObjectiveWe performed a multicentre retrospective analysis of reasons for deviation from first‐line treatment in 2008–2012.MethodsOne to three‐year survival data were analysed using Kaplan‐Meier method.ResultsA total of 407 consecutive HCC patients (66.6 ± 3 years, 83% male) with cirrhosis were included. Tumours were detected during surveillance in 53% of patients, grouped as Child‐Pugh A (67%), B (25%) and C (8%); and BCLC A (including stage 0, 44%), B (26%), C (15%) and D (15%). In 31% of patients, first‐line treatment was not feasible (51% in early stages) due to: technical reasons (74%); patient non‐conformity (20%); medical decision (3%); and disease progression (3%). One to three‐year survival of patients not receiving the recommended first‐line treatment was similar to that of patients treated according to BCLC recommendations (log‐rank, p =  0.229).ConclusionIn real‐life practice one‐third of HCC patients could not receive first‐line BCLC treatment. In our cohort of patients, similar short and medium‐term survival was observed. Long‐term prospective studies are required to determine the best alternative treatment option when BCLC first‐line treatment is not feasible.
Enhanced recovery programmes in colorectal surgery are less enhanced later in the week: An observational study
Authors: Ihedioha Ugochukuwu , Esmail Faatimah , Lloyd G , Miller Andrew , Singh Baljit , Chaudhri Sanjay 
Published: March 2015

Summary Objectives Since the introduction and favourable early results of the enhanced recovery programme more than a decade ago, it has become increasingly popular following major abdominal surgery. The programme has now been adopted in the UK. The aim of our study was to see if the day of surgery affected hospital stay and we compared patients who had colorectal surgery early in the week (Monday to Wednesday) with those who had it later in the week (Thursday to Friday). Design Patient outcomes were studied between May 2010 and April 2011 from a prospectively maintained database. All colorectal surgeons involved in the enhanced recovery programme in our unit have a flexible rota and so no surgeon was operating on a particular day to avoid bias. An enhanced recovery programme protocol was utilised for all the patients with no bowel preparation, early feeding and early mobilisation. Setting Study was carried out at the University Hospitals of Leicester. Participants Patients undergoing elective colorectal resection between Monday and Friday. Main outcome measure Hospital stay. Results Two hundred and twenty-seven patients underwent surgery and were on the enhanced recovery programme during this period. Two (0.9%) patients who had surgery on a Sunday were excluded. Two hundred and twenty-five patients were analysed of which 155 (69%) were in the group (Monday to Wednesday) and 70 (31%) in the group (Thursday to Friday). No significant differences were observed amongst the groups for age (p = 0.129), sex (p = 0.555), tumour location (p = 0.140), operation performed (p = 0.127), type of surgery (laparoscopy or open, p = 0.892), complications (p = 0.428). However, a significant shorter length of stay was present in the first group six days (interquartile range: 4–10) versus eight days (interquartile range: 5–11) (p = 0.045). Conclusion Operating on colorectal patients early in the week is associated with a significant decreased hospital stay. This should be put into consideration by units practising enhanced recovery programme if the maximal benefit of this is to be attained.
Doctors currently in jobs with academic content and their future intentions to pursue clinical academic careers: questionnaire surveys
Authors: Lambert Trevor W , Smith Fay , Goldacre Michael J 
Published: March 2015

Summary Objectives Our aim was to report on doctors’ descriptions of their current post at about 12 years after qualification, in respect of academic content, and to compare this with their long-term intentions. By academic content, we mean posts that are designated as clinical academic posts or clinical service posts that include research and/or teaching commitments. Design Questionnaire survey. Participants All UK medical graduates of 1996 contacted in 2007, graduates of 1999 in 2012, and graduates of 2000 in 2012. Setting UK. Main outcome measures Responses about current posts and future intentions. Method Postal and email questionnaires. Results The response rate was 61.9% (6713/10844). Twenty eight per cent were working in posts with academic content (3.3% as clinical academics, 25% in clinical posts with some academic content). Seventeen per cent of women were working in clinical posts with some teaching and research, compared with 29% of men. A higher percentage of men than women intended to be clinical academics as their eventual career choice (3.9% overall, 5.4% of men, 2.7% of women). More doctors wished to move to a job with an academic component than away from one (N = 824 compared with 236). This was true for both men (433 compared with 118) and women (391 compared with 118). Conclusions Women are under-represented both in holding posts with academic content and in aspirations to do so. It is noteworthy that many more doctors hoped to move into an academic role than to move out of one. Policy should facilitate this wish in order to address current shortfalls in clinical academic medicine.
Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis
Authors: Denninger Katja CM , Litman Thomas , Marstrand Troels , Moller Kristian , Svensson Lars , Labuda Tord , Andersson Åsa 
Published: March 2015

Abstract
Introduction
Pathological bone changes differ considerably between inflammatory arthritic diseases and most studies have focused on bone erosion. Collagen-induced arthritis (CIA) is a model for rheumatoid arthritis, which, in addition to bone erosion, demonstrates bone formation at the time of clinical manifestations. The objective of this study was to use this model to characterise the histological and molecular changes in bone remodelling, and relate these to the clinical disease development.

Methods
A histological and gene expression profiling time-course study on bone remodelling in CIA was linked to onset of clinical symptoms. Global gene expression was studied with a gene chip array system.

Results
The main histopathological changes in bone structure and inflammation occurred during the first two weeks following the onset of clinical symptoms in the joint. Hereafter, the inflammation declined and remodelling of formed bone dominated.
Global gene expression profiling showed simultaneous upregulation of genes related to bone changes and inflammation in week 0 to 2 after onset of clinical disease. Furthermore, we observed time-dependent expression of genes involved in early and late osteoblast differentiation and function, which mirrored the histopathological bone changes. The differentially expressed genes belong to the bone morphogenetic pathway (BMP) and, in addition, include the osteoblast markers integrin-binding sialoprotein (Ibsp), bone gamma-carboxyglutamate protein (Bglap1), and secreted phosphoprotein 1 (Spp1). Pregnancy-associated protein A (Pappa) and periostin (Postn), differentially expressed in the early disease phase, are proposed to participate in bone formation, and we suggest that they play a role in early bone formation in the CIA model. Comparison to human genome-wide association studies (GWAS) revealed differential expression of several genes associated with human arthritis.

Conclusions
In the CIA model, bone formation in the joint starts shortly after onset of clinical symptoms, which results in bony fusion within one to two weeks. This makes it a candidate model for investigating the relationship between inflammation and bone formation in inflammatory arthritis.
Chronic rhinosinusitis: An under-researched epidemic
Authors: Rudmik Luke 
Published: March 2015

Background Chronic rhinosinusitis (CRS) is a highly prevalent inflammatory disease with significant impacts on patient quality of life and daily productivity. Evaluating the volume of research on CRS, relative to similar chronic diseases, may provide insight into current disparities in research prioritization. Methods A systematic review was performed using Ovid MEDLINE (R) (1970 – December 31st, 2014) to define the volume of research publications for CRS, asthma, and diabetes mellitus (DM). Primary outcomes were overall volume of research publications and volume of publications per year. A subgroup analysis was performed using chi-square (χ2) omnibus test with 2×3 contingency tables to identify significant differences in the proportion of total randomized controlled trials, systematic reviews, meta-analyses, and economic evaluation publications between CRS, asthma, and DM groups. Results There were substantial disparities in the volume of research published over the last 45 years for CRS (n = 7,962), asthma (n = 136,652), and DM (n = 337,411). Although the volume of research for CRS in increasing, the disparities in the annual publication volumes between CRS, asthma, and DM appeared consistent over the last 45 years. Conclusions Outcomes from this review have demonstrated a large disparity in the volume of published research for CRS compared to asthma and DM. Given the similarities in prevalence rates, impact on quality of life and economic burden, the relative under supply of CRS research should prompt efforts to increase research prioritization for this chronic disease.
Evolution of a block cave from time-lapse passive source body-wave traveltime tomography
Authors: Mercier Jean-Philippe , de Beer Willem , Mercier Jean-Pascal , Morris Simon 
Published: March 2015

Most underground mines are equipped with microseismic monitoring systems that allow the detection, location, and characterization of microseismic events. Microseismic events can be exploited to understand the rock mass response to mining. However, seismicity provides information only for regions that are seismically active. Although some information on nonseismically active regions can be obtained from point measurements and numerical modeling, these methods suffer from limitations of their own. Passive source traveltime body-wave tomography (passive source tomography [PST]) uses information readily collected by microseismic monitoring systems, namely, the P- and/or S-wave traveltimes and microseismic event hypocenter locations. This technique allowes the simultaneous estimation of the velocity distribution between sensors and microseismic events and the correction of microseismic event hypocenter locations. In this paper, we present an application of time-lapse PST to the Northparkes Mines E26 Lift 2 block cave showing that PST can be used to obtain information on evolution and distribution of seismic velocities, leading to a better understanding of stress distribution and redistribution and of rock mass behavior during the development and production phases. In particular, we found that (1) the magnitude of the velocity perturbation varied through time and appeared to be strongly correlated with the intensity of microseismic activity, the mining rate, and the nature of the mining activity, (2) the velocity models provided information that allowed for the inference of the cave geometry and its evolution through time, (3) the stress distributions inferred from the velocity model were not fully consistent with a widely accepted conceptual stress redistribution model, which may reflect the significant influence of rock mass inhomogeneities and the mining sequence, (4) seismicity was found in regions in which velocity was higher and lower than the background velocity, and (5) there was no obvious correlation between geology and velocity distribution and evolution.
Assessment of 4D seismic repeatability and CO2 detection limits using a sparse permanent land array at the Aquistore CO2 storage site
Authors: Roach Lisa A. N. , White Donald J. , Roberts Brian 
Published: March 2015

Two 3D time-lapse seismic surveys were acquired in 2012 and 2013 at the Aquistore [Formula: see text] storage site prior to the start of [Formula: see text] injection. Using these surveys, we determined the background time-lapse noise at the site and assessed the feasibility of using a sparse areal permanent receiver array as a monitoring tool. Applying a standard processing sequence to these data, we adequately imaged the reservoir at 3150–3350 m depth. Evaluation of the impact of each processing step on the repeatability revealed a general monotonic increase in similarity between the data sets as a function of processing. The prestack processing sequence reduced the normalized root mean squared difference (nrms) from 1.13 between the raw stacks to 0.13 after poststack time migration. The postmigration cross-equalization sequence further reduced the global nrms to 0.07. A simulation of the changes in seismic response due to a range of [Formula: see text] injection scenarios suggested that [Formula: see text] was detectable within the reservoir at the Aquistore site provided that zones of greater thickness than 6–13 m have reached [Formula: see text] saturations of greater than 5%.
Generating a high-resolution global gravity model for oil exploration: Part 1 — Land data compilations
Authors: Fairhead J. D. 
Published: March 2015

Summary During the 10-year period 1986–1995, Getech undertook five gravity and five magnetic continental-scale data-compilation projects funded by the oil and mineral industries. The projects significantly improved the resolution of the gravity and magnetic fields over most of the continental land areas to provide new geophysical exploration tools of 5-minute (∼ 10-km) grids for gravity and 1-km grids for magnetic data. The databases were designed to help evaluate the regional nature and extent of sedimentary basins and how they relate to plate-tectonic processes. The five projects discussed here were challenging and involved complex negotiations with Russian and Chinese authorities as well as encouraging oil companies to sponsor and open their archives to release long-forgotten data sets into the studies. This article examines how these studies came about, how they evolved with new data-processing methods and technologies, and how the projects tend to be open-ended.
Penguin lungs and air sacs: implications for baroprotection, oxygen stores and buoyancy
Authors: Ponganis P. J. , St Leger J. , Scadeng M. 
Published: March 2015

ABSTRACT
The anatomy and volume of the penguin respiratory system contribute significantly to pulmonary baroprotection, the body O2 store, buoyancy and hence the overall diving physiology of penguins. Therefore, three-dimensional reconstructions from computerized tomographic (CT) scans of live penguins were utilized to measure lung volumes, air sac volumes, tracheobronchial volumes and total body volumes at different inflation pressures in three species with different dive capacities [Adélie (Pygoscelis adeliae), king (Aptenodytes patagonicus) and emperor (A. forsteri) penguins]. Lung volumes scaled to body mass according to published avian allometrics. Air sac volumes at 30 cm H2O (2.94 kPa) inflation pressure, the assumed maximum volume possible prior to deep dives, were two to three times allometric air sac predictions and also two to three times previously determined end-of-dive total air volumes. Although it is unknown whether penguins inhale to such high volumes prior to dives, these values were supported by (a) body density/buoyancy calculations, (b) prior air volume measurements in free-diving ducks and (c) previous suggestions that penguins may exhale air prior to the final portions of deep dives. Based upon air capillary volumes, parabronchial volumes and tracheobronchial volumes estimated from the measured lung/airway volumes and the only available morphometry study of a penguin lung, the presumed maximum air sac volumes resulted in air sac volume to air capillary/parabronchial/tracheobronchial volume ratios that were not large enough to prevent barotrauma to the non-collapsing, rigid air capillaries during the deepest dives of all three species, and during many routine dives of king and emperor penguins. We conclude that volume reduction of airways and lung air spaces, via compression, constriction or blood engorgement, must occur to provide pulmonary baroprotection at depth. It is also possible that relative air capillary and parabronchial volumes are smaller in these deeper-diving species than in the spheniscid penguin of the morphometry study. If penguins do inhale to this maximum air sac volume prior to their deepest dives, the magnitude and distribution of the body O2 store would change considerably. In emperor penguins, total body O2 would increase by 75%, and the respiratory fraction would increase from 33% to 61%. We emphasize that the maximum pre-dive respiratory air volume is still unknown in penguins. However, even lesser increases in air sac volume prior to a dive would still significantly increase the O2 store. More refined evaluations of the respiratory O2 store and baroprotective mechanisms in penguins await further investigation of species-specific lung morphometry, start-of-dive air volumes and body buoyancy, and the possibility of air exhalation during dives.