bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Assembled Nanohelixes Driven by Host‐Guest Interactions and Metal Coordination
Authors: Lou Xin‐Yue , Zhang Kun , Bai Yujie , Zhang Siyuan , Li Yuanyuan , Yang Ying‐Wei 
Published: August 2024

AbstractHelical nanostructures fabricated via the self‐assembly of artificial motifs have been a captivating subject because of their structural aesthetics and multiple functionalities. Herein, we report the facile construction of a self‐assembled nanohelix (NH) by leveraging an achiral aggregation‐induced emission (AIE) luminogen (G) and pillar[5]arene (H), driven by host–guest interactions and metal coordination. Inspired by the “sergeants and soldiers” effect and “majority rule” principle, the host–guest complexation between G and H is employed to fixate the twisted conformation of G for the generation of “contortion sites”, which further induced the emergence of helicity as the 1D assemblies are formed via Ag(I) coordination and hexagonally packed into nano‐sized fibers. The strategy has proved feasible in both homogeneous and heterogeneous syntheses. Along with the formation of NH, boosted luminescence and enhanced productivity of reactive oxygen species (ROS) are afforded because of the efficient restriction on G, indicating the concurrent regulation of NH′s morphology and photophysical properties by supramolecular assembly. In addition, NH also exhibits the capacity for bacteria imaging and photodynamic antibacterial activities against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli).
Leveraging long short‐term memory networks and transfer learning for the soft‐measurement of flue gas flowrate from coal‐fired boilers
Authors: Lu Jiahui , Tang Hongjian , Duan Lunbo 
Published: August 2024

AbstractThe dynamic operation and deep peak‐shaving of power‐generating units cause significant fluctuations in flue gas flowrate, thus affecting the accuracy of CO2 emissions measured by continuous emission monitoring systems (CEMS). This study established a long short‐term memory network with an attention mechanism (LSTM‐AM) for the soft measurement of the flue gas flowrate in real‐time. First, flue gas flowrate data and continuous operation parameters over 25 days were sampled from a typical 660 MW coal‐fired boiler in China. Then, a carbon balance model was established to verify the data reliability. The LSTM‐AM model was trained and testified at the 660 MW coal‐fired boiler. Results show that the LSTM‐AM model significantly surpassed the pristine LSTM model without attention, the convolutional neural network (CNN) with LSTM, and the static support vector regression (SVR) model in the real‐time prediction of flue gas flowrate. Finally, the LSTM‐AM model was generalized to a 630 MW coal‐fired power unit via transfer learning, which was further demonstrated to outperform the model re‐trained from scratch. This work manifests the feasibility of deep learning for the soft measurement of flue gas flowrate, which is promising to solve data‐lagging issues when measuring CO2 emissions from coal‐fired power plants.
Impact of citric acid on guar gum carboxymethylcellulose crosslinked blend films
Authors: Morais Marcos Antonio Pereira , Silva Mauricio , Barros Maria , Halley Peter , Almeida Yeda , Vinhas Gloria 
Published: August 2024

AbstractThis research intends to create biodegradable packaging films using solution casting method. The films are composed of guar gum, carboxymethylcellulose, and blends of these materials with citric acid as a crosslinking agent. The concentration of citric acid ranges from 10 to 30% (w w−1). This study performs a curing treatment at 140°C for 30 min on the dried films containing the crosslinking additive to promote the esterification between the polymeric matrix and the crosslinking agent. The thin films have a smooth, homogeneous, and transparent aspect. Although the crosslinking reaction – evidenced by FTIR spectra – does not affect the thickness of the material, it causes a slight color variation making the samples assume a yellowish shade. Moreover, the crosslinking process enhances the water resistance, decreases the crystallinity index, and improves the water vapor barrier and thermal resistance of the films. The SEM images reveal the excess of unreacted crosslinking agent accumulated on the samples; these particles work as a plasticizer, affecting the morphology of the films as well as their water resistance, crystallinity, and thermal resistance.
Archaeological LiDAR in Mediterranean Karst Landscapes. A Multiproxy Dating Method for Archaeological Landscape and a Case Study From Prehistoric Kras Plateau (Slovenia)
Authors: Lozić Edisa , Štular Benjamin 
Published: August 2024

ABSTRACTThe case study area is a small but typical prehistoric landscape in the Kras Plateau on the north coast of the central Mediterranean. The Late Bronze and Iron Age Kras Plateau was an emblematic Mediterranean archaeological landscape dotted with numerous hillforts. Since the mid‐20th century, the landscape had been overgrown with some of the most archaeology‐hostile vegetation, severely impeding landscape archaeology until archaeological LiDAR revealed thousands of archaeological features that attest to a carefully constructed and managed agro‐pastoral landscape. However, these discoveries were hampered by insecure chronology typical of any LiDAR guided analysis. This case study meticulously documented two prehistoric hillforts and a previously unknown agro‐pastoral landscape with hundreds of archaeological features. The focus of the article, however, was on establishing a more precise and objective dating method. We proposed a multiproxy method to date the archaeological landscape. It combines relative dating using remote sensing data and historical maps; dating based on historical context; relative stratigraphic dating; indirect dating based on associated archaeological finds; and dating by association. Particularly, we focused on the association‐based dating of archaeological features. We proposed a method based on the concept of taskscapes that relies on kernel density estimation. Using these methods, we objectively demonstrated that agro‐pastoral landscape features documented with archaeological LiDAR were contemporaneous with Late Bronze Age and Iron Age hillforts and have no connection to the post‐medieval landscape. The latter has important methodological implications for the prehistoric archaeology of Mediterranean karst landscapes, where backdating post‐Medieval landscapes is a common practise.
Dry‐Pressed Fabrication of Lithium‐Ion Electrodes Over 500 μm Thick
Authors: Hu Kedi , Fu William , West Alan C. , Steingart Daniel A. 
Published: August 2024

AbstractIn stationary storage, thick electrodes can minimize inactive material components to increase energy density and decrease cost, but they face challenges in performance and manufacturability. This work discusses a method to fabricate thick‐format lithium‐ion electrodes and a model to explore transport constraints for functional thick electrodes. Thick lithium iron phosphate (LFP) electrodes were fabricated using a solvent‐free pressing process that adopts methods from alkaline electrode manufacturing for low‐cost scale‐up. LFP electrodes with thicknesses up to 1 mm and capacities up to ~15 mAh/cm2 exhibited good rate performance (~98 % utilization at C/10, ~95 % at C/5, ~76 % at C/2). A physics‐based LFP half‐cell model was developed to aid in characterizing transport within these thick electrodes, revealing opportunities to further improve performance by decreasing tortuosity.
Folate and Vitamin B12 Status in Women of Reproductive Age in Rural Haryana, India: Estimating Population‐Based Prevalence for Neural Tube Defects
Authors: Das Reena , Duggal Mona , Rosenthal Jorge , Kankaria Ankita , Senee Hari K. , Jabbar Shameem , Kaur Manmeet , Kumar Vishal , Bhardwaj Swati , Singh Neha , Dhanjal Gursharan S. , Kumar Akash , Rose Charles E. , Bhatia Rita , Gupta Rachita , Dalpath Suresh , Crider Krista S. , Zhang Mindy , Pfeiffer Christine M. , Gupta Rakesh , Mehta Rajesh , Raina Neena , Yeung Lorraine F. 
Published: August 2024

ABSTRACTBackgroundFolate and vitamin B12 deficiencies in pregnant women are associated with increased risk for adverse maternal and infant health outcomes, including neural tube defects (NTDs).MethodsA population‐based cross‐sectional survey was conducted in two rural areas in Ambala District, Haryana, India in 2017 to assess baseline folate and vitamin B12 status among women of reproductive age (WRA) and predict the prevalence of NTDs. We calculated the prevalence of folate and vitamin B12 deficiency and insufficiency by demographic characteristics among 775 non‐pregnant, non‐lactating WRA (18–49 years). Using red blood cell (RBC) folate distributions and an established Bayesian model, we predicted NTD prevalence. All analyses were conducted using SAS‐callable SUDAAN Version 11.0.4 to account for complex survey design.ResultsAmong WRA, 10.1% (95% CI: 7.9, 12.7) and 9.3% (95% CI: 7.4, 11.6) had serum (<7 nmol/L) and RBC folate (<305 nmol/L) deficiency, respectively. The prevalence of RBC folate insufficiency (<748 nmol/L) was 78.3% (95% CI: 75.0, 81.3) and the predicted NTD prevalence was 21.0 (95% uncertainly interval: 16.9, 25.9) per 10,000 live births. Prevalences of vitamin B12 deficiency (<200 pg/mL) and marginal deficiency (≥200 pg/mL and ≤300 pg/mL) were 57.7% (95% CI: 53.9, 61.4) and 23.5% (95% CI: 20.4, 26.9), respectively.ConclusionsThe magnitude of folate insufficiency and vitamin B12 deficiency in this Northern Indian population is a substantial public health concern. The findings from the survey help establish the baseline against which results from future post‐fortification surveys can be compared.
Propolis suppresses atopic dermatitis through targeting the MKK4 pathway
Authors: Cho Ye‐Ryeong , Han Eui Jeong , Heo Eun , Jayasinghe Arachchige Maheshika Kumari , Won Jihyun , Lee Soohwan , Kim Taegun , Kim Sung‐Kuk , Lim Seokwon , Woo Soon Ok , Han Gyoonhee , Kang Wonku , Ahn Ginnae , Byun Sanguine 
Published: August 2024

AbstractPropolis is a natural resinous substance made by bees through mixing various plant sources. Propolis has been widely recognized as a functional food due to its diverse range of beneficial bioactivities. However, the therapeutic effects of consuming propolis against atopic dermatitis (AD) remain largely unknown. The current study aimed to investigate the potential efficacy of propolis against AD and explore the active compound as well as the direct molecular target. In HaCaT keratinocytes, propolis inhibited TNF‐α‐induced interleukin (IL)‐6 and IL‐8 secretion. It also led to a reduction in chemokines such as monocyte chemoattractant protein‐1 (MCP‐1) and macrophage‐derived chemokine (MDC), while restoring the levels of barrier proteins, filaggrin and involucrin. Propolis exhibited similar effects in AD‐like human skin, leading to the suppression of AD markers and the restoration of barrier proteins. In DNCB‐induced mice, oral administration of propolis attenuated AD symptoms, improved barrier function, and reduced scratching frequency and transepidermal water loss (TEWL). In addition, propolis reversed the mRNA levels of AD‐related markers in mouse dorsal skin. These effects were attributed to caffeic acid phenethyl ester (CAPE), the active compound identified by comparing major components of propolis. Mechanistic studies revealed that CAPE as well as propolis could directly and selectively target MKK4. Collectively, these findings demonstrate that propolis may be used as a functional food agent for the treatment of AD.
A Hydrogen Bonded Non‐Porous Organic‐Inorganic Framework for Measuring Cysteine in Blood Plasma and Endogenous Cancer Cell
Authors: Ghosh Riya , Pradhan Debjani , Debnath Snehasish , Mansingh Arushi , Nagesh Narayana , Chatterjee Pabitra B. 
Published: August 2024

AbstractAn imbalance in cysteine (Cys) levels in the cells and plasma has been identified as the risk indicator for various human diseases. The structural similarity of cysteine with its congener homocysteine and glutathione offers challenges in its measurement. Herein, we report a hydrogen‐bonded organic‐inorganic framework of Cu(II) (HOIF) for the selective detection of cysteine over other biothiols. The non‐fluorescent HOIF showed 12‐fold green emission in the presence of cysteine. The monomeric unit of HOIF is stabilized via intermolecular hydrogen bonds, resulting in a non‐porous network structure. Non‐interference from homocysteine, glutathione, and other competitive bio‐analytes revealed explicit affinity of HOIF for cysteine. Fluorimetric titration showed a wide working concentration window (650 nM–800 μM) for measuring cysteine in an aqueous medium. The mechanistic investigation involving HRMS, EPR, and UV‐vis spectroscopic studies revealed the decomplexation of HOIF with Cys, resulting in a fluorescence turn‐on response from the luminescent ligand. Validation using a commercial dye, “Cysteine Green”, confirmed the prospect of HOIF for early diagnostic purposes. Utilizing the fluorescence turn‐on property of HOIF in the presence of cysteine, we measured cysteine quantitatively in the blood plasma samples. Bio‐imaging of endogenous cysteine in cancer cells indicated the ability of HOIF to monitor the intracellular cysteine.
Main‐Group Elements Enhance Electrochemical Nitrogen Reduction Reaction of Vanadium‐Based Single Atom Catalysts Through d‐p Orbital Hybridization
Authors: Wang Haoyu , Hu Riming , Zhu Ruochen , Xue Liang , Yang Shuaijun , Nie Yong , Yu Jiayuan , Jiang Xuchuan 
Published: August 2024

AbstractDeveloping active sites with flexibility and diversity is crucial for single atom catalysts (SACs) towards sustainable nitrogen fixation at ambient conditions. Herein, the effects of doping main group metal elements (MGM) on the stability, catalytic activity, and selectivity of vanadium‐based SACs is systematically investigated based on density functional theory calculations. It is found that the catalytic activity of V site can be significantly enhanced by the synergistic effect between MGM and vanadium atoms. More importantly, a volcano curve between the catalytic activity and the adsorption free energy of NNH* can be established, in which V−Pb dimer embedded on N‐coordinated graphene (VPb‐NG) exhibits optimal NRR activity due to its location at the top of volcano. Further analysis of electronic structures reveals that the unoccupancy ratio (eg/t2g) of V site is dramatically increased by the strong d‐p orbital hybridization between V and Pb atoms, subsequently, N2 is activated to a larger extent. These interesting findings may provide a new path for designing active sites in SACs with excellent performance.
Peripheral immune biomarkers for immune checkpoint inhibition of solid tumours
Authors: Goswami Meghali , Toney Nicole J. , Pitts Stephanie C. , Celades Carolina , Schlom Jeffrey , Donahue Renee N. 
Published: August 2024

AbstractBackgroundWith the rapid adoption of immunotherapy for the treatment of cancer comes the pressing need for readily accessible biomarkers to guide immunotherapeutic strategies and offer insights into outcomes with specific treatments. Regular sampling of solid tumour tissues outside of melanoma for immune monitoring is not often feasible; conversely, routine, frequent interrogation of circulating immune biomarkers is entirely possible. As immunotherapies and immune checkpoint inhibitors, in particular, are more widely used in first‐line, neoadjuvant, and metastatic settings, the discovery and validation of peripheral immune biomarkers are urgently needed across solid tumour types for improved prediction and prognostication of clinical outcomes in response to immunotherapy, as well as elucidation of mechanistic underpinnings of the intervention. Careful experimental design, encompassing both retrospective and prospective studies, is required in such biomarker identification studies, and concerted efforts are essential for their advancement into clinical settings.ConclusionIn this review, we summarize shared immune features between the tumour microenvironment and systemic circulation, evaluate exploratory peripheral immune biomarker studies, and discuss associations between candidate biomarkers with clinical outcomes. We also consider integration of multiple peripheral immune parameters for better prediction and prognostication and discuss considerations in study design to further evaluate the clinical utility of candidate peripheral immune biomarkers for immunotherapy of solid tumours.Highlights
Peripheral immune biomarkers are critical for improved prediction and prognostication of clinical outcomes for patients with solid tumours treated with immune checkpoint inhibition.
Candidate peripheral biomarkers, such as cytokines, soluble factors, and immune cells, have potential as biomarkers to guide immunotherapy of solid tumours.
Multiple peripheral immune parameters may be integrated to improve prediction and prognostication.
The potential of peripheral immune biomarkers to guide immunotherapy of solid tumours requires critical work in biomarker discovery, validation, and standardization.
The role of maximal inspiratory pressure on functional performance in adults with heart failure
Authors: Shah Rohan V. , Cahalin Lawrence P. , Haus Jacob M. , Allsup Kelly , Delligatti Amanda , Wolf Cody , Checko (Scioli) Erica R. , Aragam Jayashri R. , Gottlieb Daniel J. , Byard Thomas D. , Forman Daniel E. 
Published: August 2024

AbstractBackgroundExercise intolerance is common among adults with heart failure (HF) and is a strong prognostic indicator. We examined maximal inspiratory pressure (MIP) as an indicator of maximal and submaximal exercise capacity in older HF patients.MethodsFifty‐one patients age ≥ 50 years with HF underwent MIP testing via the PrO2 device. Peak oxygen uptake (VO2), 6 min walk distance (6MWD), 30 s sit‐to‐stand test (STS), gait speed (GS), grip strength and lower extremity muscle strength [one‐repetition maximum (1RM)] were measured. Correlation and exploratory multiple regression analyses investigated relationships between MIP, left ventricular ejection fraction (LVEF), age, body mass index (BMI) and physical function. MIP was then stratified by median (64 cm H2O), and endpoints were compared between median groups.ResultsThe median age was 69 years [interquartile range (IQR): 66–73], and the median LVEF was 36.5% (IQR: 30%–45%). Regression identified MIP as an independent predictor for grip strength, 6MWD, 1RM weight and 30 s STS after adjustment for age, BMI and LVEF. MIP greater than the median (n = 25) independently predicted and reflected greater peak VO2 [14.2 (12.8–18.1) vs. 11.5 (9.7–13.0) mL/kg/min; P = 0.0007] as well as 6MWD, 1RM, 30 s STS and GS (all P < 0.05).ConclusionThe analysis demonstrates that MIP is a novel biometric for exercise tolerance in adults with HF. Assessments of MIP are safe and convenient, with the potential to enhance routine HF surveillance and provide novel biometrics to guide HF therapeutics.
Functionalized Phosphorus‐Doped Porous Organic Polymers (FPPOPs) ‐Promoted Pd‐Catalyzed Arylation of Hydrosilanes
Authors: Chen Yi‐Lin , Tian Shu‐Yuan , Wang Yan , Lu Si‐Qi , Xu Zheng , Yin Guan‐Wu , Yang Ke‐Fang , Xu Li‐Wen 
Published: August 2024

AbstractThe development of novel catalyst systems, especially as highly efficient heterogeneous catalysts for Si−C bond ‐forming arylation reaction of hydrosilanes is highly desirable. Herein, we developed a simple and eco‐friendly methodology for construction of functionalized phosphorus‐doped porous organic polymers (FPPOPs) and its heterogeneous palladium catalyst through anchoring on FPPOPs bearing a phosphine ligand, in which the fabrication of FPPOPs was completed through the vinyl‐substituted triphenylphosphine (ViPPh3) and vinyl‐substituted polyhedral oligomeric silsequioxane (ViPOSS) as well as functional olefins via radical co‐polymerization. All these FPPOPs could act as a phosphine ligand for Pd‐catalyzed arylation of hydrosilanes have been characterized by SEM, FTIR, and X‐RAD. Moreover, the POSS‐based functionalized phosphorus‐doped porous organic polymers (POSS‐PPOPs) proved to be a high efficiency catalyst system for Si−C bond ‐forming arylation of hydrosilanes with aryl iodides and with good yields as well as excellent chemoselectivity with low amount of catalyst under mild conditions. The mechanistic studies supported the effect of functional group on the catalytic activity of Pd/FPPOPs catalyst, which revealed that the weak coordination as well as non‐covalent interaction between porous organic polymers and substrate played important role in the enhancement of chemoselectivity.
Introducing the brief reverse correlation: An improved tool to assess visual representations
Authors: Schmitz Mathias , Rougier Marine , Yzerbyt Vincent 
Published: August 2024

AbstractThe reverse correlation is an innovative method to capture visual representations (i.e., classification images, CIs) of social targets. However, this method necessitates many trials to compute high‐quality CIs, which poses important practical and economic challenges. We introduce a new version of the reverse correlation method, namely, the Brief‐RC. By increasing the number of stimuli (i.e., noisy faces) presented at each trial, the Brief‐RC improves the quality of individual (and average) CIs and lowers the overall task length. In two experiments, assessments by external judges confirmed that the new method delivers equally good (Experiment 1) or higher‐quality (Experiment 2) outcomes than the traditional method for the same number of trials, time length and number of stimuli. The informational values of CIs were also compared using a more objective metric (infoVal). Because the Brief‐RC facilitates the production of higher‐quality individual CIs, social psychology researchers may more easily address a series of relevant research questions.
The curse of objectivity: Choosing objectively better products hinders consumers from receiving help
Authors: Qiu Tian , Lu Jingyi 
Published: August 2024

AbstractConsumers who desire to be ‘rational’ tend to rely on reason and resist affective influences and thus choose objective options that are superior on quantifiable and measurable attributes but inferior on subjective and malleable attributes. Existing research reveals that consumers experience intrapersonal benefits from choosing objective options. Beyond these benefits, this study reveals the novel and interpersonal curse of choosing objective options that hinders consumers from receiving help. Six studies found that, compared to subjective‐option choosers, objective‐option choosers were considered less warm and received less help. Moreover, this social curse was attenuated when consumers’ choices did not reflect their own preferences. The current research contributes to the literature on objectivity–subjectivity trade‐offs by extending it from the intrapersonal to the interpersonal perspective, and to the literature on helping by revealing how consumption reduces future help received in irrelevant contexts beyond current consumption.