bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minnesota diatomists: The first 150 years
Authors: EDLUND MARK B. 
Published: August 2013

Minnesota boasts over 12,000 lakes, most of glacial origin, three major continental drainage systems (Mississippi River to the Gulf of Mexico, Lake Superior via the other Great Lakes to the Atlantic Ocean, and the Red River of the North via the Nelson River, to Hudson Bay), and a diversity of landforms comprising seven major ecological regions. Such landscape and aquatic variability hosts a high diversity of diatoms, which have been studied for over 150 years. Diatom communities range from saline and eutrophic in the southwest agricultural lands, to oligotrophic and endemic forms in the cold waters of Lake Superior. Early diatom collections were distributed to reknowned diatomists such as C.G. Ehrenberg and H.L. Smith. Other botanists and phycologists, including Tilden, Eddy, and Drouet, were active in Minnesota but only rarely included diatoms in their studies. Interest in Minnesota diatoms increased in the latter half of the 20th century with taxonomic and floristic surveys (e.g., Czarnecki, Koppen, and Kingston) and the inclusion of diatoms in applied research efforts that set the groundwork for understanding post-glacial ecology, effects of Euroamerican settlement, impacts of climate, and the effects of acid precipitation. Important to these latter developments were the efforts of Dr. Herb Wright Jr., who invited several European diatomists (e.g., Florin, Battarbee, and Haworth) to work on paleoecological projects in and near Minnesota. Although not a diatomist per se, Wright's subsequent efforts to promote diatom research included the appointment of Platt Bradbury as a research associate and later John Kingston, Dick Brugam, and Brian Cumming. Students Sheri Fritz, Kate Laird, and Virginia Card completed diatom research for their doctoral degrees. These workers and others have left a legacy that continues to fuel several active labs in Minnesota that have used diatoms to develop water quality standards, assess and restore impaired waters, and understand the impacts of climate, management, and landuse change across the state.
Arabic-speaking religious leaders’ perceptions of the causes of mental illness and the use of medication for treatment
Authors: Youssef Jacqueline , Deane Frank P 
Published: August 2013

Objectives: The Arabic-speaking clergy is highly revered and considered the first point of contact for people who suffer from mental illness within their community. The current study aimed to explore the beliefs of Arabic-speaking religious leaders regarding the causes of mental illness and the use of medication for their treatment. Method: Participants consisted of 170 Arabic-speaking clerics of Muslim ( n = 85) and Christian ( n = 85) denominations residing in Sydney, Australia. A questionnaire was administered during face-to-face interviews and included items regarding the causes of mental illness and beliefs about whether psychiatric medications were viewed as helpful or harmful. Results: Most of the Arabic-speaking clerics viewed drug and alcohol addiction and psychosocial factors as the most important causes of mental illness. Biological causes such as a chemical imbalance in the brain were less frequently endorsed. Although medications were viewed by most religious clerics as helpful in the treatment of mental illness, there were also concerns about the potential harms of medications, particularly among Muslim clerics. Muslim clerics also endorsed the religious causes for mental illness, such as spiritual poverty, as being more important more so than did Christian clerics. Conclusions: The beliefs of Arabic-speaking religious leaders influence how they respond to people with mental illness and may determine whether they refer people to professional mental health services or not. Understanding their perspectives allows opportunities to share information to facilitate collaborative work in the care of Arabic-speaking people with mental illness. Arabic-speaking religious leaders need to be better educated about the mechanisms of action and benefits of medication in the treatment of mental illness.
Muriel Driver Memorial Lecture 2013
Authors: Finlayson Marcia L. 
Published: August 2013

Background. Given the nature of occupational therapy philosophy and practice, it is not surprising that “change agent” has been identified as one of the seven professional roles that occupational therapists fulfill. Purpose. This Muriel Driver lecture examines the change agent role, what it means, and what knowledge, skills, and personal qualities are necessary to be effective. Key Issues. Overall, relatively little has been written about the change agent role in the occupational therapy literature. Much of what does exist is implicit and often embedded in related topics, such as advocacy. An examination of literature from outside of occupational therapy uncovered four major themes about this role: (a) Change agents are insightful, reflective, and disciplined; (b) Change agents are visionary leaders and mobilizers; (c) Change agents are knowledge integrators and translators; and (d) Change agents are diplomatic interventionists who produce meaningful outcomes. These themes point to several areas of silence in the occupational therapy literature. Implications. Overcoming these areas of silence and moving forward will require open, challenging, and scholarly debates; reconsideration of change agent role competencies; and clear messaging that we all have the capacity to be competent and effective change agents regardless of our title or setting.
Prospects for using a hemoconcentrator as an alternative hemodialysis method in cardiopulmonary bypass surgeries
Authors: Tagaya M , Matsuda M , Yakehiro M , Izutani H 
Published: August 2013

Objective: Cardioplegic solutions often cause high blood concentrations of potassium. The conventional hemoconcentration circuit was improved to correct electrolyte imbalances through a method involving dilutional ultrafiltration (DUF) and an alternative hemodialysis (ALTHD) method. This study aimed to determine the effectiveness of this ALTHD method. Methods: Bovine blood was used, in conjunction with a hemoconcentrator, in an experimental hemodialysis (HD) circuit to evaluate an ALTHD method. The effectiveness of the method was determined by electrolyte and hematocrit measurements following the procedure. Results: The ALTHD method corrected electrolyte levels as effectively as DUF and was less affected by dilution than DUF. Conclusion: The ALTHD method may provide faster electrolyte adjustments than DUF because its efficiency depends on both the blood and dialysate flow rates. In addition, the ALTHD method is expected to provide increased efficiency. Thus, our DUF/ALTHD circuit-switching method may be clinically useful when rapid electrolyte correction is required.
RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice
Authors: Vries Boukje de , Eising Else , Broos Ludo AM , Koelewijn Stephany C , Todorov Boyan , Frants Rune R , Boer Judith M , Ferrari Michel D , Hoen Peter AC ‘t , Maagdenberg Arn MJM van den 
Published: August 2013

Background Various CACNA1A missense mutations cause familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of migraine with aura. FHM1 mutation R192Q is associated with pure hemiplegic migraine, whereas the S218L mutation causes hemiplegic migraine, cerebellar ataxia, seizures, and mild head trauma-induced brain edema. Transgenic knock-in (KI) migraine mouse models were generated that carried either the FHM1 R192Q or the S218L mutation and were shown to exhibit increased CaV2.1 channel activity. Here we investigated their cerebellar and caudal cortical transcriptome. Methods Caudal cortical and cerebellar RNA expression profiles from mutant and wild-type mice were studied using microarrays. Respective brain regions were selected based on their relevance to migraine aura and ataxia. Relevant expression changes were further investigated at RNA and protein level by quantitative polymerase chain reaction (qPCR) and/or immunohistochemistry, respectively. Results Expression differences in the cerebellum were most pronounced in S218L mice. Particularly, tyrosine hydroxylase, a marker of delayed cerebellar maturation, appeared strongly upregulated in S218L cerebella. In contrast, only minimal expression differences were observed in the caudal cortex of either mutant mice strain. Conclusion Despite pronounced consequences of migraine gene mutations at the neurobiological level, changes in cortical RNA expression in FHM1 migraine mice compared to wild-type are modest. In contrast, pronounced RNA expression changes are seen in the cerebellum of S218L mice and may explain their cerebellar ataxia phenotype.
Freeze-dried and spray-dried zinc-containing silica microparticles entrapping insulin
Authors: Vanea Emilia , Moraru Corina , Vulpoi Adriana , Cavalu Simona , Simon Viorica 
Published: August 2013

New approaches for oral administration of insulin are strongly related to novel insulin carriers. The aim of this study was the insulin microencapsulation in a new zinc-silica matrix for drug protection and controlled release. Zinc-silica microparticles loaded with insulin were obtained by sol-gel process via spray drying and freeze drying methods. Inorganic silica matrix isolates and constrains the movement of the biomolecules preventing their aggregation and denaturation, while the zinc oxide improves the system stability. Moreover, formation of insulin hexamers in the presence of zinc ions leads to an increased stability of the insulin three-dimensional structure during preparation, storage and release. The particles were characterized with respect to average size, specific surface area, porosity and morphology. In vitro behavior of insulin-loaded particles together with protein structural conformation was also evaluated. The release profile can be adapted by synthesis route of microparticles.
Rapamycin regulates connective tissue growth factor expression of lung epithelial cells via phosphoinositide 3-kinase
Authors: Xu Xuefeng , Wan Xuan , Geng Jing , Li Fei , Yang Ting , Dai Huaping 
Published: August 2013

The pathogenesis of idiopathic pulmonary fibrosis (IPF) remains largely unknown. It is believed that IPF is mainly driven by activated alveolar epithelial cells that have a compromised migration capacity, and that also produce substances (such as connective tissue growth factor, CTGF) that contribute to fibroblast activation and matrix protein accumulation. Because the mechanisms regulating these processes are unclear, the aim of this study was to determine the role of rapamycin in regulating epithelial cell migration and CTGF expression. Transformed epithelial cell line A549 and normal human pulmonary alveolar or bronchial epithelial cells were cultured in regular medium or medium containing rapamycin. Real time reverse transcriptase polymerase chain reaction was employed to determine CTGF mRNA expression. Western blotting and an enzyme-linked immunosorbent assay were used for detecting CTGF protein. Wound healing and migration assays were used to determine the cell migration potential. Transforming growth factor (TGF)-β type I receptor (TβRI) inhibitor, SB431542 and phosphoinositide 3-kinase (PI3K) inhibitor, LY294002 were used to determine rapamycin’s mechanism of action. It was found that treatment of A549 and normal human alveolar or bronchial epithelial cells with rapamycin significantly promoted basal or TGF-β1 induced CTGF expression. LY294002, not SB431542 attenuated the promotional effect of rapamycin on CTGF expression. Cell mobility was not affected by rapamycin in wound healing and migration assays. These data suggest rapamycin has a profibrotic effect in vitro and underscore the potential of combined therapeutic approach with PI3K and mammalian target of rapamycin inhibitors for the treatment of animal or human lung fibrosis.
A mixed methods exploration of family members’/friends’ roles in a self-care intervention for depressive symptoms
Authors: Sussman Tamara , Yaffe Mark , Mccusker Jane , Burns Victoria , Strumpf Erin , Sewitch Maida , Belzile Eric 
Published: August 2013

Objectives The aims of this exploratory study were to examine the: (1) family and friend (F/F) support patients reported receiving and F/F reported providing to patients while participating in a self-care intervention (SCI) for depressive symptoms and (2) associations between different types of F/F support and patients’ use of the self-care tools in the SCI. Methods Fifty-seven patients aged 40 + participating in an uncontrolled feasibility study of an SCI, completed structured telephone interviews about the support they received from F/F while participating in the SCI. Eighteen F/F completed questionnaires on the support they provided to patients during the SCI. Seven F/F participated in a post-study qualitative interview on their involvement in the SCI. Results About 35% of patients reported receiving F/F support with the SCI. Patients’ use of the behavioral tools was positively associated with patients’ report of F/F support, and with F/F’s report of instrumental support provided. F/F reported uncertainty about the type of support they should offer to patients in the SCI. Discussion F/F involvement in SCIs for depressive symptoms may be helpful to patients and may foster adherence to these interventions. More research is warranted on the nature of such involvement from the perspective of patients and F/F.
Illness perceptions in Turkish migrants with diabetes: A qualitative study
Authors: Yilmaz-Aslan Yüce , Brzoska Patrick , Bluhm Martina , Aslan Abdulselam , Razum Oliver 
Published: August 2013

Objectives Illness perceptions are usually conceptualized using the self-regulatory model of illness. Although a few examinations of illness perceptions among Turkish language populations exist, the validity of the self-regulatory model of illness has never been confirmed for this population group. The aim of our study was to explore the validity of the self-regulatory model of illness in chronically ill Turkish migrants residing in Germany using diabetes mellitus type 2 as an example. Methods Qualitative semi-structured interviews were conducted with 24 Turkish migrants with self-reported diabetes who were recruited through key persons. The core aspects of the qualitative data were extracted through a hermeneutic approach. Subsequently, a system of categories and sub-categories was developed by means of content analysis. Results Seven distinct core dimensions of illness perceptions, each with a different number of sub-domains, could be identified in the sample. They comprised the perceived timeline of diabetes, its consequences, its causes, its controllability as well as the identity/coherence and the emotional response with respect to the condition. Discussion As regards the conceptualization of illness perceptions, the dimensions identified are in line with the self-regulatory model of illness. Addressing illness perceptions through tailored interventions may contribute to improving health care and health outcomes in Turkish migrants.
The Use of an Orthopaedic Rating System in Major League Baseball
Authors: McGahan Patrick J. , Fronek Jan , Hoenecke Heinz R. , Keefe Daniel 
Published: August 2013

Background: Although the majority of Major League Baseball teams use an orthopaedic rating system to evaluate draft picks, little has been published on the topic. Hypothesis: Our goal was to assess the attitudes among Major League Baseball physicians regarding 3 common diagnoses in pitching prospects, through the use of an orthopaedic rating system. Our hypothesis was that the assigned orthopaedic grades would vary among physicians, diagnoses, and operative-versus-nonoperative and recent-versus-past treatment. Study Design: Survey. Level of Evidence: Level 4. Methods: A survey in the form of 12 clinical vignettes was used to query Major League Baseball physicians regarding ulnar collateral ligament (UCL) injuries, type II superior labrum anterior posterior (SLAP) tears, and internal impingement. Respondents graded draft picks using an orthopaedic rating system. The vignettes covered both operative and nonoperative and recent and past treatment (successful return to pitching for 1 year). Results: The orthopaedic grades assigned by respondents were as follows (minimal, moderate, severe risk): past UCL reconstruction (73%, 27%, 0%), recent UCL reconstruction (19%, 77%, 4%), past UCL strain (28%, 60%, 12%), recent UCL strain (0%, 48%, 52%), past SLAP repair (52%, 48%, 0%), recent SLAP repair (4%, 64%, 32%), past SLAP nonoperative (28%, 60%, 12%), recent SLAP nonoperative (0%, 36%, 64%), past internal impingement operative (24%, 68%, 8%), recent internal impingement operative (8%, 32%, 60%), past internal impingement nonoperative (24%, 68%, 8%), and recent internal impingement nonoperative (4%, 48%, 44%). Conclusion: Team physicians are optimistic regarding the outcome of UCL reconstruction. In contrast, UCL strains, type II SLAP lesions, and internal impingement carry a guarded prognosis. For all diagnoses, regardless of treatment, the prognosis improved if a player returned to pitching for 1 full season. Clinical Relevance: This study represents a first step toward developing a standardized orthopaedic rating system that will facilitate more accurate player assessment and clearer communication among physicians.
Approximation of homomorphisms and derivations on Lie "Equation missing" -algebras via fixed point method
Authors: Cho Yeol Je , Saadati Reza , Yang Young-Oh 
Published: August 2013

Abstract
In this paper, using fixed point methods, we prove the generalized Hyers-Ulam stability of homomorphisms in

C
∗

-algebras and Lie

C
∗

-algebras and of derivations on C∗-algebras and Lie C∗-algebras for an m-variable additive functional equation.

MSC:39A10, 39B52, 39B72, 46L05, 47H10, 46B03.
P-TRAP: a Panicle Trait Phenotyping tool
Authors: AL-Tam Faroq , Adam Helene , Anjos António dos , Lorieux Mathias , Larmande Pierre , Ghesquière Alain , Jouannic Stefan , Shahbazkia Hamid Reza 
Published: August 2013

Abstract

Background
In crops, inflorescence complexity and the shape and size of the seed are among the most important characters that influence yield. For example, rice panicles vary considerably in the number and order of branches, elongation of the axis, and the shape and size of the seed. Manual low-throughput phenotyping methods are time consuming, and the results are unreliable. However, high-throughput image analysis of the qualitative and quantitative traits of rice panicles is essential for understanding the diversity of the panicle as well as for breeding programs.

Results
This paper presents P-TRAP software (Panicle TRAit Phenotyping), a free open source application for high-throughput measurements of panicle architecture and seed-related traits. The software is written in Java and can be used with different platforms (the user-friendly Graphical User Interface (GUI) uses Netbeans Platform 7.3). The application offers three main tools: a tool for the analysis of panicle structure, a spikelet/grain counting tool, and a tool for the analysis of seed shape. The three tools can be used independently or simultaneously for analysis of the same image. Results are then reported in the Extensible Markup Language (XML) and Comma Separated Values (CSV) file formats. Images of rice panicles were used to evaluate the efficiency and robustness of the software. Compared to data obtained by manual processing, P-TRAP produced reliable results in a much shorter time. In addition, manual processing is not repeatable because dry panicles are vulnerable to damage. The software is very useful, practical and collects much more data than human operators.

Conclusions
P-TRAP is a new open source software that automatically recognizes the structure of a panicle and the seeds on the panicle in numeric images. The software processes and quantifies several traits related to panicle structure, detects and counts the grains, and measures their shape parameters. In short, P-TRAP offers both efficient results and a user-friendly environment for experiments. The experimental results showed very good accuracy compared to field operator, expert verification and well-known academic methods.
Factors associated with burnout among Chinese hospital doctors: a cross-sectional study
Authors: Wu Hui , Liu Li , Wang Yang , Gao Fei , Zhao Xue , Wang Lie 
Published: August 2013

Abstract

Background
Burnout has been a major concern in the field of occupational health. However, there is a paucity of research exploring the factors related to burnout among Chinese doctors. Investigation of these factors is important to improve the health of doctors and the quality of healthcare services in China.

Methods
The study population consisted of 1,618 registered hospital doctors from Liaoning province of China. Burnout was measured using the Chinese version of the Maslach Burnout Inventory-General Survey. Occupational stress was measured using the Chinese versions of the Job Content Questionnaire and the Effort-Reward Imbalance Questionnaire. Data were collected on the respondents’ demographic characteristics and work situations. Of the doctors solicited for enrollment, 1,202 returned the completed questionnaire (555 men, 647 women), giving a response rate of 74.3%. A general linear regression model was applied to analyze the factors associated with burnout.

Results
The burnout mean scores were 11.46 (7.51) for emotional exhaustion, 6.93 (5.15) for cynicism, and 24.07 (9.50) for professional efficacy. In descending order of standardized estimates, variables that predicted a high level of emotional exhaustion included: high extrinsic effort, dissatisfaction with doctor-patient relationship, high overcommitment, working >40 h per week, low reward, and high psychological job demands. Variables that predicted a high level of cynicism included: high extrinsic effort, low reward, dissatisfaction with doctor-patient relationship, high overcommitment, low decision authority, low supervisor support, and low skill discretion. Variables that predicted a low perceived professional efficacy included: high psychological job demands, low coworker support, high extrinsic effort, low decision authority, low reward, and dissatisfaction with doctor-patient relationship.

Conclusions
These findings suggest that occupational stress is strongly related to burnout among hospital doctors in China. Strategies that aim to improve work situations and decrease occupational stress are necessary to reduce burnout, including health education, health promotion, and occupational training programs.