bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Sequential Deoxyfluorination Approach for the Synthesis of Protected α,β,γ‐Trifluoro‐δ‐amino Acids.
Authors: Cheerlavancha Raju , Lawer Aggie , Cagnes Marina , Bhadbhade Mohan , Hunter Luke 
Published: March 2014

AbstractThe synthesis of two novel δ‐amino acid derivatives (VII) and (X) containing three vicinal fluorine atoms placed stereospecifically in the backbone is detailed.
ChemInform Abstract: Development of Novel LpxC Inhibitors: Chiral‐Pool Synthesis of C‐Triazolyl Glycosides.
Authors: Jana Sunit Kumar , Loeppenberg Marius , Daniliuc Constantin G. , Jose Joachim , Holl Ralph 
Published: March 2014

AbstractIn a chiral pool synthesis starting from D‐mannose, hydroxamic acids (IV) are synthesized.
ChemInform Abstract: Domino Reaction Involving (Diacetoxyiodo)benzene‐Promoted Oxidative Rearrangement: A Novel Multicomponent and Efficient Strategy for the Synthesis of Thiadiazole N‐Nucleosides.
Authors: Siddiqui Ibadur R. , Siddiqui Naz Akhtar , Shamim Shayna , Shireen Shireen , Srivastava Anjali 
Published: March 2014

AbstractTitle compounds (IV) are efficiently synthesized by an environmentally benign three‐component one‐pot cyclization procedure via Hofmann rearrangement of thiamide (II).
ChemInform Abstract: Microwave Assisted Synthesis of Cu2O Crystals with Morphological Evolution from Octapod to Octahedron.
Authors: Cho Young‐Sik , Huh Young‐Duk 
Published: March 2014

AbstractCu2O crystals are prepared from aqueous mixtures of CuCl2, TMEDA, D(+)‐glucose, and polyethylene glycol (microwave irradiation, 2 min, ≈46% yield).
Aspartate‐containing neurons of the brainstem and rostral spinal cord of the sea lamprey Petromyzon marinus: Distribution and comparison with γ‐aminobutyric acid
Authors: Villar‐Cerviño Verona , Fernández‐López Blanca , Celina Rodicio María , Anadón Ramón 
Published: March 2014

ABSTRACTThe amino acid L‐aspartate (ASP) is one of the most abundant excitatory neurotransmitters in the mammalian brain, but its distribution in other vertebrates has not yet been well characterized. We investigated the distribution of ASP in the brainstem and rostral spinal cord of the adult sea lamprey by using ASP immunohistochemistry. Our results indicate that ASP is accumulated in specific neurons, but not in glia (tanycytes). ASP‐immunoreactive neuronal populations were rather similar as the glutamatergic populations reported in the adult sea lamprey (Villar‐Cerviño et al. [2013] J Comp Neurol 521:522–557), although some important differences were noted. Characteristically, the largest reticular neurons of the lamprey brainstem (Müller cells) showed ASP immunoreactivity in perikarya and processes, in contrast to the absence or faint glutamate immunoreactivity reported in these perikarya. We also compared the distribution of ASP and γ‐aminobutyric acid (GABA) in brainstem neurons by using double immunofluorescence methods. In regions such as the midbrain tectum, dorsal isthmus, and motor nuclei, ASP and GABA immunoreactivity was mostly located in different neurons, whereas in other nuclei (torus semicircularis, octavolateralis area, parvocellular reticular formation), many of the ASP‐immunonegative neurons displayed colocalization with GABA. These results, together with those of our previous studies of colocalization of glutamate and GABA, suggest that some lamprey neurons may co‐release both excitatory and inhibitory neurotransmitters. Further investigation is needed to elucidate the pathways of uptake and release of ASP by ASP‐immunoreactive neurons. Our results indicate that ASP is a neurotransmitter in the central nervous system representative of agnathans, the earliest vertebrate group. J. Comp. Neurol. 522:1209–1231, 2014. © 2013 Wiley Periodicals, Inc.
Delivering Web service load testing as a service with a global cloud
Authors: Yan Minzhi , Sun Hailong , Liu Xudong , Deng Ting , Wang Xu 
Published: March 2014

SummaryIn this paper, we present WS‐TaaS, a Web services load testing platform built on a global platform PlanetLab. WS‐TaaS enables load testing process to be simple, transparent, and as close as possible to the real running scenarios of the target services. First, we briefly introduce the base of WS‐TaaS, Service4All. Second, we provide detailed analysis of the requirements of Web service load testing and present its conceptual architecture as well as algorithm design for improving resource utilization. Third, we present the implementation details of WS‐TaaS. Finally, we perform the evaluation of WS‐TaaS with a set of experiments based on the testing of real Web services, and the results illustrate that WS‐TaaS can efficiently facilitate the whole process of Web service load testing. Especially, comparing with existing testing tools, WS‐TaaS can obtain more effective and accurate test results. Copyright © 2014 John Wiley & Sons, Ltd.
An economic market for the brokering of time and budget guarantees
Authors: Kavanagh Richard , Djemame Karim 
Published: March 2014

SummaryGrids offer best effort services to users. Service level agreements offer the opportunity to provide guarantees upon services offered, in such a way that it captures the users' requirements, while also considering concerns of the service providers. This is achieved via a process of converging requirements and service cost values from both sides towards an agreement. This paper presents the intelligent scheduling for quality of service market‐oriented mechanism for brokering guarantees upon completion time and cost for jobs submitted to a batch‐oriented compute service. Web Services agreement (negotiation) is used along with the planning of schedules in determining pricing, ensuring that jobs become prioritised depending on their budget constraints. An evaluation is performed to demonstrate how market mechanisms can be used to achieve this, whilst also showing the effects that scheduling algorithms can have upon the market in terms of rescheduling. The evaluation is completed with a comparison of the broker's capabilities in relation to the literature. Copyright © 2014 John Wiley & Sons, Ltd.
Modeling and performance analysis of information diffusion under information overload in Facebook‐like social networks
Authors: Li Pei , Sun Yunchuan 
Published: March 2014

SUMMARYResearch on social networks has received remarkable attention, because an increasing number of people use social networks to broadcast information and stay connected with their friends. However, because of the information overload in social networks, it becomes increasingly difficult for users to find useful information. This paper takes Facebook‐like social networks into account and proposes models to capture the characters such as the network, the user behaviors, and the process of information diffusion under information overload. The term type influence is introduced to characterize the information diffusion efficiency for users of a given type, which can be analyzed theoretically on the basis of the proposed models. Having noticed the inaccuracy of using type influence to estimate the information diffusion efficiency for a given user, we further introduce the term individual influence and propose a scalable approach to estimate it. We verify the accuracy of this approach by simulations and show that considering more nearby users leads to more computational costs, but more accurate results. Copyright © 2014 John Wiley & Sons, Ltd.
Physical infrastructure interdependency and regional resilience index after the 2011 Tohoku Earthquake in Japan
Authors: Cimellaro Gian Paolo , Solari Daniele , Bruneau Michel 
Published: March 2014

SUMMARYA resilience index is used to quantify preventive measures, emergency measures, and restoration measures of complex systems, such as physical infrastructures, when they are subjected to natural disasters like earthquakes, hurricanes, floods, etc. Interdependencies among these systems can generate cascading failures or amplification effects, which can also affect the restoration measures right after an extreme event and generate a reduction of the resilience index. In this article, a method is proposed to evaluate the physical infrastructure resilience of a region affected by a disaster considering infrastructure interdependency. It is illustrated using available restoration curves from the March 11 2011 Tohoku Earthquake in Japan. The weights assigned to each infrastructure, which are used to determine resilience, are evaluated using the degree of interdependency indices which are obtain by time series analysis. Results show that the weight coefficients thus obtained do not influence the resilience index significantly; however, the methodology proposed is unbiased from subjective judgment and is able to identify the critical lifelines. Furthermore, the results of the case study presented here suggest that to obtain meaningful estimation of the weight coefficients, it is necessary to consider the period range between two perturbations (e.g., main shock and aftershock). Future infrastructure disruption data (from this and other earthquakes) would be needed to generalize this finding that will allow also to quantify the changes in the restoration curves caused by the magnitude and distance of the shocks from the epicenter, as well as the intrinsic properties of the physical infrastructures. Copyright © 2014 John Wiley & Sons, Ltd.
Cytotoxic properties of the leaf essential oils of Guatteria blepharophylla and Guatteria hispida (Annonaceae)
Authors: Ferraz Rosana P. C. , Bomfim Diogo S. , Carvalho Nanashara C. , Soares Milena B. P. , Pinheiro Maria L. B. , Costa Emmanoel V. , Bezerra Daniel P. 
Published: March 2014

ABSTRACTGuatteria blepharophylla Mart. (synonym Guatteriopsis blepharophylla Mart.) and Guatteria hispida (R.E. Fr.) Erkens & Maas (synonym Guatteriopsis hispida R.E. Fr.) belong to the Annonaceae family and are found in the Brazilian and Colombian Amazon basin. Both species are popularly known as ‘envira’ or ‘envireira’. In the present study, the leaf essential oils of G. blepharophylla (EOGB) and G. hispida (EOGH) were selected to investigate their cytotoxic effects. Tumour cell lines were treated with increasing concentrations of both essential oils for 72 h and analysed by a methyl‐[3H]thymidine incorporation assay. The pro‐apoptotic effect of these essential oils was assessed in HepG2 cells by morphological analysis (using haematoxylin/eosin staining and acridine orange/ethidium bromide staining), flow cytometry (cell membrane integrity and internucleosomal DNA fragmentation analysis) and a caspase‐3 activation assay after 24 h incubation. Both essential oils displayed potent cytotoxicity in different tumour cell lines. EOGB showed IC50 values from 6.03 to 16.46 µg/ml for HepG2 and K562 cell lines, and EOGH showed IC50 values from 5.45 to 24.89 µg/ml for HepG2 and K562 cell lines, respectively. Cell morphologies consistent with apoptosis and a remarkable activation of caspase‐3 were observed in the HepG2 cells treated with essential oils for 24 h. Significant increases in internucleosomal DNA fragmentation without altered membrane integrity were also found. In conclusion, both essential oils investigated were able to inhibit tumour cell proliferation and induce cell death by apoptosis pathways. Copyright © 2014 John Wiley & Sons, Ltd.
Hypoxic regulation of the PERK/ATF4/LAMP3‐arm of the unfolded protein response in head and neck squamous cell carcinoma
Authors: Nagelkerke Anika , Sweep Fred C. G. J. , Stegeman Hanneke , Grénman Reidar , Kaanders Johannes H. A. M. , Bussink Johan , Span Paul N. 
Published: March 2014

AbstractBackgroundThe purpose of this study was to examine the hypoxic regulation of the PKR‐like endoplasmic reticulum kinase (PERK)/activating transcription factor‐4 (ATF4)/lysosome‐associated membrane protein 3 (LAMP3)‐arm of the unfolded protein response (UPR) in head and neck squamous cell carcinoma (HNSCC).MethodsLAMP3 expression was determined in patient biopsies by immunohistochemistry and correlated to clinicopathological parameters. mRNA and protein expression for PERK, ATF4, and LAMP3 was evaluated after hypoxic exposure of HNSCC cell lines.ResultsIn patients with HNSCC, high LAMP3 expression correlated with N classification (p = .019) and the occurrence of distant metastases during follow‐up (p = .039). Patients with high LAMP3 levels had a worse metastasis‐free survival (p = .008). Intriguingly, LAMP3 expression was localized exclusively in normoxic areas of tumors and xenografts. Expression of PERK, p‐PERK, p‐eIF2α, ATF4, and LAMP3 was not universally induced in hypoxic HNSCC cell lines. Exposure to endoplasmic reticulum‐stress stimulated PERK, ATF4, and LAMP3 expression.ConclusionLAMP3 is relevant for prognosis in HNSCC. However, the PERK/ATF4/LAMP3‐arm of the UPR responds differently to hypoxia in HNSCC compared to other tumor types. © 2014 Wiley Periodicals, Inc. Head Neck 37: 896–905, 2015
Race/ethnicity, nativity and trends in BMI among U.S. adults
Authors: Krueger Patrick M. , Coleman‐Minahan Kate , Rooks Ronica N. 
Published: March 2014

ObjectiveThe average BMI is rising even as the U.S. population grows increasingly diverse. Prior research by examining BMI trends in diverse groups including whites, blacks, Chinese, Filipinos, Asian Indians, Mexicans, Puerto Ricans, and Cubans who are U.S. born, recent immigrants, or long‐term immigrants was extended.MethodsCross‐sectional data from the 1989 to 2011 waves of the National Health Interview Survey (N = 989,273) have been pooled and linear regression models to examine trends in BMI among U.S. adults have been used.ResultsAnnual increases in BMI are greatest among U.S.‐born Puerto Ricans and Mexicans and slowest among foreign born Chinese. Among the U.S. born in 2011, Chinese adults have an average BMI below the threshold for overweight, whereas blacks, Mexicans, and Puerto Ricans have average BMIs in the obese range. Foreign‐born adults average lower BMIs than U.S. born adults in most race/ethnic groups, and nativity disparities generally widen over time. BMI increases across calendar periods rather than birth cohorts.ConclusionOur results suggest that calendar period interventions may be particularly useful in reversing rising BMIs in the United States. However, interventions must be tailored to different race/ethnic and nativity groups in order to reduce disparities in body mass.
Perceptions of body mass index (BMI) in pediatric cancer survivors and their providers
Authors: Elchuri Swati V. , Patterson Briana C. , Wasilewski‐Masker Karen , Mertens Ann C. , Record Elizabeth , Meacham Lillian R. 
Published: March 2014

AbstractBackgroundAbnormalities in BMI are well documented in childhood cancer survivors. Perceptions of BMI status in cancer survivors have been understudied. This study determines the accuracy of parent/survivor and provider reporting of BMI status in a cancer survivor program.ProcedureThis is a retrospective study. Parent/survivor assessment of BMI status was obtained from a baseline questionnaire of subjects enrolled in Children's Healthcare of Atlanta‐Childhood, Adolescent, and Young Adult Cancer Survivor Study (CHOA‐CAYACSS). Provider reporting of BMI was obtained from a clinic visit close in date to completion of the survey. Perceptions of BMI were compared to actual BMI status calculated from clinic visits and categorized based on the Centers for Disease Control and Prevention (CDC) BMI guidelines.ResultsPerceptions of BMI were collected from 290 survivors of pediatric cancer or their parents (range, 4.3–22.9 years). Nearly 5% of survivors were underweight, 19.7% overweight and 16.2% obese. High BMI was the BMI state least likely to be correctly identified by parents, survivors, and providers. Among survivors with high BMI, parents, survivors, and providers failed to identify the problem 49.4%, 66.7%, and 26.9% of the time, respectively. Providers were less likely to correctly identify overweight compared to obese status (P < 0.0001). Accuracy of BMI recognition was independent of gender of survivor, ethnicity, or primary cancer diagnosis.ConclusionAbnormal BMI states, especially overweight, are frequently not correctly perceived by parents/survivors or providers. Assessment of BMI status and discussion about steps to normalize BMI is needed to prevent weight related morbidities in this population. Pediatr Blood Cancer 2014; 61:1445–1450. © 2014 Wiley Periodicals, Inc.
Secondary malignant neoplasms after high‐dose chemotherapy and autologous stem cell rescue for high‐risk neuroblastoma
Authors: Martin Alissa , Schneiderman Jennifer , Helenowski Irene B. , Morgan Elaine , Dilley Kimberley , Danner‐Koptik Karina , Hatahet Mohamad , Shimada Hiroyuki , Cohn Susan L. , Kletzel Morris , Hijiya Nobuko 
Published: March 2014

BackgroundOutcomes for high‐risk neuroblastoma remain poor. Modern treatment protocols utilizing intense induction followed by myeloablative consolidation chemotherapy with autologous stem cell rescue (ASCR) have improved survival rates, but the long‐term sequelae, including development of secondary malignant neoplasms (SMN), are just now surfacing.MethodsWe retrospectively reviewed data from 87 patients with high‐risk neuroblastoma who were treated with intensive induction chemotherapy followed by ASCR between January 1991 and July 2011 following one of two institutional protocols: Chicago Pilot 1 (CP1; n = 12) and Chicago Pilot 2 (CP2; n = 75).ResultsThe 15‐year overall survival rate for all 87 patients was 33.9% (95% confidence interval [CI], 23.1–45.0%). The 10‐ and 15‐year cumulative incidence of SMN was 16.5% (95%CI, 7.2–38.0%) and 34.2% (95%CI, 18.6–63.1%), respectively, without evidence of a plateau at 15 years. Six of the 10 patients (n = 2 in CP1 and n = 8 in CP2) who developed SMN had hematologic malignancies including acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS). Solid tumors included thyroid papillary carcinoma, chondrosarcoma, hepatocellular carcinoma, and biliary adenocarcinoma.ConclusionA significantly higher incidence of SMN, especially hematological malignancies, was observed in this cohort compared to older neuroblastoma studies, potentially due to exposure to epipodophyllotoxins and a high cumulative dose of alkylating agents these patients received. The risk of developing an SMN continued to increase with survival time and did not reach the plateau at 15 years. Although the number of the patients is relatively small, our study emphasizes the need for life‐long follow‐up of survivors who were treated using modern therapy. Pediatr Blood Cancer 2014; 61:1350–1356. © 2014 Wiley Periodicals, Inc.
Constructing a place for critical practice in China: the history and outlook of the journal Time + Architecture
Authors: Ding Guanghui , Hale Jonathan , Parnell Steve 
Published: March 2014

This paper investigates the history and programme of the Chinese architectural journal Time + Architecture (Shidai Jianzhu). As one of the newly established architectural periodicals in post-Mao China, the journal was launched in 1984 by academics Luo Xiaowei, Wang Shaozhou and their colleagues at the Department of Architecture in Tongji University, Shanghai. The journal's close association with academic institutions and commercial design firms shaped its dual nature; that is, both scholarly and professional. At the turn of the millennium, the journal's substantial reform of editorial policy redefined its character from a ‘presenter’ of received materials to a ‘producer’ of selected collaborative work, and enabled it to maintain editorial distinctiveness in the Chinese architectural publishing scene.This paper argues that Time + Architecture constructed a significant place for critical practice in contemporary China through the presentation of critical architecture and architectural criticism. Over the past few decades, the journal, under the editorship of Zhi Wenjun, published a number of special issues on the work of emerging independent architects such as Yung Ho Chang, Wang Shu, Liu Jiakun and others. The thematic topics, projects and criticisms presented by the journal exemplified an editorial agenda to publish innovative and exploratory work and demonstrated the editors' and contributors' collective endeavours to develop a critical discourse that confronted the dominant ideology of architecture.
Mitochondrial thiol oxidase Erv1: both shuttle cysteine residues are required for its function with distinct roles
Authors: Ang Swee Kim , Zhang Mengqi , Lodi Tiziana , Lu Hui 
Published: March 2014

Erv1 (essential for respiration and viability 1), is an essential component of the MIA (mitochondrial import and assembly) pathway, playing an important role in the oxidative folding of mitochondrial intermembrane space proteins. In the MIA pathway, Mia40, a thiol oxidoreductase with a CPC motif at its active site, oxidizes newly imported substrate proteins. Erv1 a FAD-dependent thiol oxidase, in turn reoxidizes Mia40 via its N-terminal Cys30–Cys33 shuttle disulfide. However, it is unclear how the two shuttle cysteine residues of Erv1 relay electrons from the Mia40 CPC motif to the Erv1 active-site Cys130–Cys133 disulfide. In the present study, using yeast genetic approaches we showed that both shuttle cysteine residues of Erv1 are required for cell growth. In organelle and in vitro studies confirmed that both shuttle cysteine residues were indeed required for import of MIA pathway substrates and Erv1 enzyme function to oxidize Mia40. Furthermore, our results revealed that the two shuttle cysteine residues of Erv1 are functionally distinct. Although Cys33 is essential for forming the intermediate disulfide Cys33–Cys130′ and transferring electrons to the redox active-site directly, Cys30 plays two important roles: (i) dominantly interacts and receives electrons from the Mia40 CPC motif; and (ii) resolves the Erv1 Cys33–Cys130 intermediate disulfide. Taken together, we conclude that both shuttle cysteine residues are required for Erv1 function, and play complementary, but distinct, roles to ensure rapid turnover of active Erv1.
Establishing IMMULITE® 2000 cut‐off values for serum allergen‐specific immunoglobulin and exploring their relationship to exhaled nitric oxide
Authors: Evjenth Bjørg , Hansen Tonje E. , Brekke Ole‐Lars , Holt Jan 
Published: March 2014

AbstractAimPaediatric cut‐off values for serum allergen‐specific IgE (sIgE) using the Siemens IMMULITE® 2000 system to diagnose allergic rhinoconjunctivitis have not been established. We aimed to determine cut‐off levels for sIgE for 10 common inhalant allergens and to study the relationship between sIgE, total IgE and fractional exhaled nitric oxide (FENO).MethodsWe enrolled 243 schoolchildren, including 164 with allergic rhinoconjunctivitis. Parental interviews, skin prick tests, sIgE, total IgE, FENO measurements, spirometry and exercise tests were performed.ResultsCut‐off values with the best combined sensitivity and specificity were above the detection limit of the assay for seven of the ten allergens (0.23–1.1 kU/L). The overall accuracy of the IMMULITE® in detecting allergic rhinoconjunctivitis was good. sIgE was superior to total IgE and FENO in predicting allergic rhinoconjunctivitis to timothy, birch, mugwort, cat, dog and house dust mite. FENO was elevated in children with allergic rhinoconjunctivitis, irrespective of asthma.ConclusionCut‐off values for sIgE were dependent on the allergic phenotype and were above the IMMULITE® detection limit for seven of ten inhalant allergens. Consequently, using the detection limit for sIgE as the decision point would result in over‐diagnosing allergic rhinoconjunctivitis. When measuring elevated FENO in children, allergic rhinoconjunctivitis should be suspected.