bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene‐environment interaction of genome‐wide association study‐identified susceptibility loci and meat‐cooking mutagens in the etiology of renal cell carcinoma
Authors: Melkonian Stephanie C. , Daniel Carrie R. , Ye Yuanqing , Tannir Nizar M. , Karam Jose A. , Matin Surena F. , Wood Christopher G. , Wu Xifeng 
Published: November 2015

BACKGROUNDMeat‐cooking mutagens may be associated with renal cell carcinoma (RCC) risk. In the current study, the authors examined associations between meat‐cooking mutagens, genetic susceptibility variants, and risk of RCC.METHODSThe authors used 659 newly diagnosed RCC cases and 699 healthy controls to investigate the association between dietary intake of meat‐cooking mutagens and RCC. They examined whether associations varied by risk factors for RCC and genetic susceptibility variants previously identified from genome‐wide association studies. Odds ratios and 95% confidence intervals were estimated using tertiles of intake of dietary polycyclic aromatic hydrocarbons/heterocyclic amines.RESULTSDietary intake of the mutagenic compounds 2‐amino‐3,8‐dimethylimidazo‐(4,5‐f) quinoxaline (MeIQx) and 2‐amino‐1 methyl‐6‐phenylimidazo(4,5‐b)pyridine (PhIP) were found to be significantly associated with an increased risk of RCC (odds ratios across tertiles: 1.00 [referent], 1.28 [95% confidence interval, 0.94‐1.74], and 1.95 [95% confidence interval, 1.43‐2.66] [P for trend <.001], respectively; and 1.00 [referent], 1.41 [95% confidence interval, 1.04‐1.90], and 1.54 [95% confidence interval, 1.14‐2.07] [P for trend =.02], respectively). The authors observed evidence of interactions between PhIP and RCC susceptibility variants in 2 genes: inositol 1,4,5‐trisphosphate receptor, type 2 (ITPR2) (rs718314; multiplicative P for interaction = .03 and additive P for interaction =.002) and endothelial PAS domain‐containing protein 1 (EPAS1) (rs7579899; additive P for interaction =.06).CONCLUSIONSThe intake of meat may increase the risk of RCC through mechanisms related to the cooking compounds MeIQx and PhIP. These associations may be modified by genetic susceptibility to RCC. Further research is necessary to understand the biological mechanisms underlying these interactions. Cancer 2016;122:108–115. © 2015 American Cancer Society.
The clinical significance of plasma neopterin in heart failure with preserved left ventricular ejection fraction
Authors: Yamamoto Eiichiro , Hirata Yoshihiro , Tokitsu Takanori , Kusaka Hiroaki , Tabata Noriaki , Tsujita Kenichi , Yamamuro Megumi , Kaikita Koichi , Watanabe Hiroshi , Hokimoto Seiji , Maruyama Toru , Ogawa Hisao 
Published: November 2015

AbstractAimsAlthough inflammation plays an important role in the pathogenesis of heart failure (HF), the precise pathophysiological role of inflammation in HF with preserved left ventricular ejection fraction (HFpEF) still remains unclear. Hence, we examined the clinical significance of plasma neopterin, an inflammatory biomarker, in HFpEF patients.Methods and resultsIn the present study, we recruited consecutive HFpEF patients hospitalized in Kumamoto University Hospital, and further measured plasma neopterin by high‐performance liquid chromatography and serum derivatives of reactive oxidative metabolites (DROM), a new biomarker of reactive oxygen species. Compared with risk factors (number of patients, age, sex, and equal incidence of diabetes mellitus, hypertension, and dyslipidemia) ‐matched non‐HF patients (n = 68), plasma neopterin levels, but not serum high‐sensitivity C‐reactive protein levels, were significantly increased in patients with HFpEF (n = 68) (P < 0.001 and P = 0.15, respectively), accompanied by an elevation in serum DROM levels (P < 0.001). Plasma neopterin levels in New York Heart Association (NYHA) class III/IV HFpEF patients were significantly higher than in NYHA class II patients (P < 0.004). Furthermore, plasma ln‐neopterin levels had significant and positive correlation with ln‐DROM values (r = 0.57) and parameters of cardiac diastolic dysfunction [the ratio of early transmitral flow velocity to tissue Doppler early diastolic mitral annular velocity (r = 0.34), left atrial volume index (r = 0.17), and B‐type natriuretic peptide (r = 0.38)]. Kaplan–Meier analysis showed that the high‐neopterin group (>51.5 nM: median value of neopterin in HFpEF patients) had a higher probability of cardiovascular events than the low‐neopterin group (log‐rank test, P = 0.003).ConclusionsPlasma neopterin levels significantly increased in HFpEF and correlated with the severity of HF. Furthermore, high neopterin were significantly correlated with future cardiovascular events, indicating that measurement of plasma neopterin might provide clinical benefits for risk stratification of HFpEF patients. © 2015 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
Synthesis and Structures of Ti‐Pd Hetero­bimetallic Complexes
Authors: Suzuki Noriyuki , Haraga Kenji , Shimamura Tatsuki , Masuyama Yoshiro 
Published: November 2015

AbstractHeterobimetallic complexes containing titanium and palladium were prepared from O,N,O–N,N multidentate ligands. The ligands each contained an O,N,O‐tridentate part based on a 2,6‐lutidine scaffold and an N,N‐bidentate di(pyridin‐2‐yl) part. The O,N,O‐moiety selectively coordinated to a titanium atom on treatment with titanium(tetraisopropoxide), although one of the di(pyridin‐2‐yl) groups in the N,N‐moiety coordinated to the titanium atom. The N,N‐bidentate di(pyridin‐2‐yl) moiety coordinated to the palladium atom on treatment with bis(benzonitrile)palladium(II) chloride to afford a heterobimetallic complex. The dynamic behavior of the complexes in solution was studied by NMR spectroscopy.
Synthesis and Structure of N‐Hetero‐ortho‐phenylene Hexamers Containing 2,3‐Substituted Pyridine Moieties
Authors: Tokoro Yuichiro , Ohtsuka Nobuhiko , Toh Ayumi , Fukuzawa Shin‐ichi 
Published: November 2015

AbstractN‐Hetero‐ortho‐phenylene hexamers with two 2,3‐substituted pyridine moieties (i.e., 1a–c) were prepared by palladium‐catalyzed homocoupling with pyridine‐directed C–H cleavage as the key step. The conformations of the resulting hexamers in solution and in the solid state were investigated by computational methods, X‐ray analysis, and 1H NMR spectroscopy. Calculations at the SCS‐MP2/def2‐TZVPP//B97‐D3(bj)/def2‐SVP level suggested that helical folding of 1a as the pyridine moieties are stacked is thermally more stable than the equivalent folding in the unsubstituted ortho‐phenylene hexamer. The conformations of single crystals of 1 were consistent with the optimized structures obtained by DFT calculations. Except for rotation of the terminal phenyl groups, only one set of signals corresponding to a helical conformation was observed by analysis of 1 by 1H NMR spectroscopy in CDCl3 solution.
The Revised Structure of Trichodermatide A
Authors: Shigehisa Hiroki , Kikuchi Harue , Suzuki Tsuyoshi , Hiroya Kou 
Published: November 2015

AbstractA revised structure for trichodermatide A, which is a C10 epimer of the originally reported structure, is proposed. The revision is supported by the X‐ray structure of a synthetic intermediate synthesized according to our previous route for trichodermatide A. The revised stereochemistry was also supported by NOESY experiment. Finally, we synthesized Trauner's compound corresponding to the originally reported structure from our synthetic intermediate of trichodermatide A through a Mitsunobu reaction at C10.
Determining octanol–water partition coefficients for extremely hydrophobic chemicals by combining “slow stirring” and solid-phase microextraction
Authors: Jonker Michiel T.O. 
Published: November 2015

Abstract

Octanol–water partition coefficients (KOW) are widely used in fate and effects modeling of chemicals. Still, high-quality experimental KOW data are scarce, in particular for very hydrophobic chemicals. This hampers reliable assessments of several fate and effect parameters and the development and validation of new models. One reason for the limited availability of experimental values may relate to the challenging nature of KOW measurements. In the present study, KOW values for 13 polycyclic aromatic hydrocarbons were determined with the gold standard “slow-stirring” method (log KOW 4.6–7.2). These values were then used as reference data for the development of an alternative method for measuring KOW. This approach combined slow stirring and equilibrium sampling of the extremely low aqueous concentrations with polydimethylsiloxane-coated solid-phase microextraction fibers, applying experimentally determined fiber–water partition coefficients. It resulted in KOW values matching the slow-stirring data very well. Therefore, the method was subsequently applied to a series of 17 moderately to extremely hydrophobic petrochemical compounds. The obtained KOW values spanned almost 6 orders of magnitude, with the highest value measuring 1010.6. The present study demonstrates that the hydrophobicity domain within which experimental KOW measurements are possible can be extended with the help of solid-phase microextraction and that experimentally determined KOW values can exceed the proposed upper limit of 109. Environ Toxicol Chem 2016;35:1371–1377. © 2015 SETAC
Altered sensorimotor activation patterns in idiopathic dystonia—an activation likelihood estimation meta‐analysis of functional brain imaging studies
Authors: Løkkegaard Annemette , Herz Damian M. , Haagensen Brian N. , Lorentzen Anne K. , Eickhoff Simon B. , Siebner Hartwig R. 
Published: November 2015

AbstractDystonia is characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements or postures. Functional neuroimaging studies have yielded abnormal task‐related sensorimotor activation in dystonia, but the results appear to be rather variable across studies. Further, study size was usually small including different types of dystonia. Here we performed an activation likelihood estimation (ALE) meta‐analysis of functional neuroimaging studies in patients with primary dystonia to test for convergence of dystonia‐related alterations in task‐related activity across studies. Activation likelihood estimates were based on previously reported regional maxima of task‐related increases or decreases in dystonia patients compared to healthy controls. The meta‐analyses encompassed data from 179 patients with dystonia reported in 18 functional neuroimaging studies using a range of sensorimotor tasks. Patients with dystonia showed bilateral increases in task‐related activation in the parietal operculum and ventral postcentral gyrus as well as right middle temporal gyrus. Decreases in task‐related activation converged in left supplementary motor area and left postcentral gyrus, right superior temporal gyrus and dorsal midbrain. Apart from the midbrain cluster, all between‐group differences in task‐related activity were retrieved in a sub‐analysis including only the 14 studies on patients with focal dystonia. For focal dystonia, an additional cluster of increased sensorimotor activation emerged in the caudal cingulate motor zone. The results show that dystonia is consistently associated with abnormal somatosensory processing in the primary and secondary somatosensory cortex along with abnormal sensorimotor activation of mesial premotor and right lateral temporal cortex. Hum Brain Mapp 37:547–557, 2016. © 2015 Wiley Periodicals, Inc.
A framework for energy use indicators and their reporting in life cycle assessment
Authors: Arvidsson Rickard , Svanström Magdalena 
Published: November 2015

Abstract
Energy use is a common impact category in life cycle assessment (LCA). Many different energy use indicators are used in LCA studies, accounting for energy use in different ways. Often, however, the choice behind which energy use indicator is applied is poorly described and motivated. To contribute to a more purposeful selection of energy use indicators and to ensure consistent and transparent reporting of energy use in LCA, a general framework for energy use indicator construction and reporting in LCA studies will be presented in this article. The framework differentiates between 1) renewable and nonrenewable energies, 2) primary and secondary energies, and 3) energy intended for energy purposes versus energy intended for material purposes. This framework is described both graphically and mathematically. Furthermore, the framework is illustrated through application to a number of energy use indicators that are frequently used in LCA studies: cumulative energy demand (CED), nonrenewable cumulative energy demand (NRCED), fossil energy use (FEU), primary fossil energy use (PFEU), and secondary energy use (SEU). To illustrate how the application of different energy use indicators may lead to different results, cradle-to-gate energy use of the bionanomaterial cellulose nanofibrils (CNF) is assessed using 5 different indicators and showing a factor of 3 differences between the highest and lowest results. The relevance of different energy use indicators to different actors and contexts will be discussed, and further developments of the framework are then suggested. Integr Environ Assess Manag 2016;12:429–436. © 2015 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of SETAC.
Key Points
This article presents a framework for energy use indicators in LCA, with the aim of contributing to a consistent selection of energy use indicators and transparent reporting of energy use in LCA. Common energy use indicators in LCA are described using the framework. An assessment of cellulose nanofibrils using different energy use indicators shows that results can vary notably depending on the choice of indicator. The relevance of different energy use indicators to societal actors, and further developments of the framework, are discussed.
Observed variability of summer precipitation pattern and extreme events in East China associated with variations of the East Asian summer monsoon
Authors: Wang Lei , Qian Yun , Zhang Yaocun , Zhao Chun , Leung L. Ruby , Huang Anning , Xiao Chuliang 
Published: November 2015

ABSTRACTThis article presents a comprehensive analysis of interannual and interdecadal variations of summer precipitation and precipitation‐related extreme events in East China associated with variations of the East Asian summer monsoon (EASM) from 1979 to 2012. A high‐quality daily precipitation data set covering 2076 observational stations in China is analysed. Based on the precipitation pattern analysis using empirical orthogonal functions and the regime shift detection method, three sub‐periods of 1979–1992 (period I), 1993–1999 (period II) and 2000–2012 (period III) are identified to be representative of the precipitation variability. Similar significant variability of the extreme precipitation indices is found across four sub‐regions in eastern China. The spatial patterns of summer mean precipitation, the number of days with daily rainfall exceeding 95th percentile precipitation (R95p) and the maximum number of consecutive wet days (CWD) anomalies are consistent, but opposite to that of maximum consecutive dry days (CDD) anomalies to some extent during the three sub‐periods. However, the spatial patterns of hydroclimatic intensity (HY‐INT) are notably different from that of the other three extreme indices, but highly correlated to the dry events. The changes of precipitation anomaly patterns are accompanied by the change of the EASM regime and the abrupt shift of the position of the west Pacific subtropical high around 1992/1993 and 1999/2000, respectively, which influence the moisture transport and contributes to the precipitation anomalies. In addition, the EASM intensity is linked to sea surface temperature anomaly over the tropical Indian and Pacific Ocean through its effects on convective activity over the west Pacific that induces the cyclonic or anticyclonic anomaly over the South China and northwest Pacific.
Exploring Brand Personality–Celebrity Endorser Personality Congruence in Celebrity Endorsements in the Indian Context
Authors: Mishra Aditya S. , Roy Subhadip , Bailey Ainsworth Anthony 
Published: November 2015

ABSTRACTThe objective of the research reported in this paper was to develop and test a model of brand personality–celebrity endorser personality congruence and its impact on consumers’ attitudes and intentions. In particular, the study drew on social adaptation and attribution theories to develop hypotheses related to the impact of this congruence on consumers’ perceptions of endorser credibility and suitability, and the subsequent impact of these perceptions on consumers’ attitudes and intentions. The study was motivated by recent attention being paid to the importance of personality in choosing celebrities for product endorsements and the fact that the brand personality–celebrity endorser personality congruence has not been explored before. The model was tested based on data obtained from a sample of participants in India. Results from path analyses indicated a positive and significant impact of personality‐based congruence on endorser credibility and suitability, which, in turn, positively and significantly impacted ad believability. Ad believability in turn significantly impacted attitude toward the ad, which had a significant impact on brand attitude and purchase intentions. Research and managerial implications are discussed, as are directions for future research.
Powell–Sabin B‐splines and unstructured standard T‐splines for the solution of the Kirchhoff–Love plate theory exploiting Bézier extraction
Authors: May Stefan , Vignollet Julien , Borst René de 
Published: November 2015

SummaryThe equations that govern Kirchhoff–Love plate theory are solved using quadratic Powell–Sabin B‐splines and unstructured standard T‐splines. Bézier extraction is exploited to make the formulation computationally efficient. Because quadratic Powell–Sabin B‐splines result in
‐continuous shape functions, they are of sufficiently high continuity to capture Kirchhoff–Love plate theory when cast in a weak form. Unlike non‐uniform rational B‐splines (NURBS), which are commonly used in isogeometric analysis, Powell–Sabin B‐splines do not necessarily capture the geometry exactly. However, the fact that they are defined on triangles instead of on quadrilaterals increases their flexibility in meshing and can make them competitive with respect to NURBS, as no bending strip method for joined NURBS patches is needed. This paper further illustrates how unstructured T‐splines can be modified such that they are
‐continuous around extraordinary points, and that the blending functions fulfil the partition of unity property. The performance of quadratic NURBS, unstructured T‐splines, Powell–Sabin B‐splines and NURBS‐to‐NURPS (non‐uniform rational Powell–Sabin B‐splines, which are obtained by a transformation from a NURBS patch) is compared in a study of a circular plate. Copyright © 2015 John Wiley & Sons, Ltd.
Residual‐based a posteriori estimators for the potential formulations of electrostatic and time‐harmonic eddy current problems with voltage or current excitation
Authors: Chen Chao , Creusé Emmanuel , Nicaise Serge , Tang Zuqi 
Published: November 2015

SummaryIn this paper, we consider some potential formulations of electrostatic as well as time‐harmonic eddy current problems with voltage or current excitation sources. The well‐posedness of each formulation is first established. Then, the reliability of the corresponding residual‐based a posteriori estimators is derived in the context of the finite element method approximation. Finally, the implementation in an industrial code is performed, and the obtained theoretical results are illustrated on an academic and on an industrial benchmark. Copyright © 2015 John Wiley & Sons, Ltd.
Spray pyrolysed thin films of copper antimony sulfide as photovoltaic absorber
Authors: Ramos Aquino Jose Agustin , Rodriguez Vela Dorian Leonardo , Shaji Sadasivan , Avellaneda David Avellaneda , Krishnan Bindu 
Published: November 2015

AbstractCopper antimony sulfide (CuSbS2) thin films have been gained interest recently as an emerging light absorbing material for photovoltaic applications. In this work we report synthesis and characterization of spray pyrolised CuSbS2 thin films. The precursor solution consisted of SbCl3, CuCl2 and NH2CSNH2 dissolved ethanol. The substrate temperature was kept at 200 °C. Samples were prepared at different molar ratios of Cu:Sb:S. These thin films were characterized using X‐ray diffraction, Raman spectroscopy, X‐ray photoelectron spectroscopy, atomic force microscopy, UV‐visible spectroscopy, photocurrent and Hall effect measurements. P‐type CuSbS2 thin films of orthorhombic structure were formed and the films showed photocurrent response. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Robot‐assisted resection of gastrointestinal stromal tumors (GIST): a single center case series and literature review
Authors: Vicente Emilio , Quijano Yolanda , Ielpo Benedetto , Duran Hipolito , Diaz Eduardo , Fabra Isabel , Malave Luis , Ferri Valentina , Ferronetti Antonio , Caruso Riccardo 
Published: November 2015

AbstractBackgroundRobotic techniques are claimed to be an alternative to laparoscopic and open approaches for gastrointestinal stromal tumors (GIST) treatment. Our aim is to present our single center experience and a literature review.Materials and methodsFrom June 2012 to August 2014, six patients with preoperative diagnosis of GIST were treated by robotic surgery at Sanchinarro University Hospital.ResultsTwo GIST tumors were localized in the second part of the duodenum, one in the first portion, two in the gastricantrum and another in the angular notch. Surgical procedures performed were two subtotal gastrectomies, one gastric wedge resection and three duodenal enucleations. None of the interventions needed conversion to open surgery. Mean operative time was 245 min (150–540). Mean hospital stay was 10.5 days (6–24). All lesions had microscopically negative resection margins. Mean follow‐up was 24 months (8–33) with a disease‐free survival rate of 100%.ConclusionsA robotic approach for GIST tumors is a safe and feasible procedure with a well‐accepted oncological surgical result. Copyright © 2015 John Wiley & Sons, Ltd.
DVB‐S2X: extending DVB‐S2 flexibility for core markets and new applications
Authors: Morello Alberto , Mignone Vittoria 
Published: November 2015

SummaryDigital Video Broadcasting–Satellite–Second Generation (DVB‐S2) has been specified about 10 years ago, with a strong focus on Direct‐to‐Home, but interactive broadband applications (forward link), digital satellite news gathering and other professional links such as internet trunking were included. Since then, new requirements have come up, including extended efficiency and flexibility in the core applications of DVB‐S2, with specific focus on ultra‐high‐definition television delivery to the home, using High Efficiency Video Coding, the new video coding technique jointly developed by ITU and MPEG, and new ones for emerging markets. DVB‐S2X provides the necessary technical specifications for covering traditional DVB‐S2 use cases and new ones for operating at very low signal‐to‐noise ratio down to −10 dB, such as mobile services for business jets, fast trains and boats, and low aperture terminals for journalists.This paper and the others in this special issue describe the details of the standard and its performance in the various application scenarios. Copyright © 2015 John Wiley & Sons, Ltd.