bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuromyelitis optica and neuromyelitis optica spectrum disorder: Natural history and long-term outcome, an Indian experience
Authors: Jagtap Sujit Abajirao , Mandliya Alok , Sarada C. , Nair M. D. 
Published: June 2015

Abstract
Background: Neuromyelitis optica (NMO) has evolved from devic′s classical description to a broader disease spectrum, from monophasic illness to a polyphasic illness with multiple recurrences, disease confined to optic nerve and spinal cord to now brain stem, cerebrum and even endocrinopathy due to hypothalamic involvement. Objectives: To report, the epidemiological characteristics, clinical presentations, recurrence rate, treatment and response to therapy in 26 patients with NMO and NMO spectrum disorder among the Indian population. Methods: We performed observational, retrospective analysis of our prospectively maintained data base of patients with NMO, longitudinally extensive transverse myelitis during the period of January 2003-December 2012 who satisfied the national multiple sclerosis society (NMSS) task force criteria for diagnosis of NMO and NMO spectrum disorder. Results: There were 26 patients (female: male, 21:5), the mean age of onset of symptom was 27 years (range 9-58, standard deviation = 12). Twenty-one patients (80%) fulfilled NMSS criteria for NMO while rest 5 patients (20%) were considered as NMO spectrum disorder. Seven patients (27%) had a monophasic illness, 19 patients (73%) had a polyphasic illness with recurrences. The Median recurrence rate was 4/patient in the polyphasic group. 13 (50%) patient were tested for aquaporin 4 antibody, 8 (61%) were positive while 5 patients (39%) were negative. All patients received intravenous methyl prednisolone, 9 patients (35%) required further treatment for acute illness in view of unresponsiveness to steroids. Thirteen patients (50%) received disease-modifying agents for recurrences. Mean duration of follow-up was 5 years. All patients had a good outcome (modified Rankin scale, <3) except one who had poor visual recovery. Conclusion: Neuromyelitis optica/NMO spectrum disorder is demyelinating disorder with female predominance, polyphasic course, myelitis being most common event although brain stem involvement is not uncommon with NMO antibody positivity in 60% patients, confirms the literature data.
Craniopharyngioma causing bilateral vision loss 4 months after unremarkable magnetic resonance imaging of the brain
Authors: Betts Rainy , Margo Curtis E. , Drucker Mitchell 
Published: June 2015

ABSTRACTA 65-year-old man developed bilateral vision loss 4 months after magnetic resonance imaging demonstrated no lesion in the vicinity of the optic chiasm, hypothalamus, and suprasellar tissues. Repeat computed tomography 3 months later showed a predominantly cystic mass of the suprasellar cistern with extension into the anterior third ventricle, which histologically was a craniopharyngioma. The clinical course of this case fuels the controversy whether craniopharyngiomas arise from embryonic rests or can be acquired. From a clinical perspective, it raises questions about when to obtain imaging studies dedicated to the chiasm and the appropriate interval in which a scan should be repeated to exclude structural causes of bilateral vision loss.
Metastatic sacrococcygeal yolk sac tumor: A misleading diagnosis
Authors: Nsir Atef Ben , Darmoul Mehdi , Arous Sarra Ben , Hattab Nejib 
Published: June 2015

ABSTRACTSacrococcygeal yolk sac tumor (YST) is an extremely rare malignant extra-gonadal germ-cell tumor, which usually succeeds to the degeneration of more common benign teratoma.We describe here an unprecedented case of conus medullaris compression by a spinal metastasis from a pure sacrococcygeal YST in a 1½ years old girl, which was misdiagnosed initially as an anal fissure and stress the need of a meticulous clinical examination and further screening in young patients presenting with sphincter disturbances.
A series of enterococcal brain abscesses
Authors: Maiti Tanmoy K. , Nagarathna S. , Veena Kumari H. B. , Shukla Dhaval P. 
Published: June 2015

ABSTRACT
Background: Neurosurgeons in developing countries come across brain abscess frequently, but Enterococcus as a cause of abscess is rare. Aims: To describe clinical profile and treatment of a series of patients with enterococcal brain abscess. Materials and Methods: We retrospectively reviewed microbiological records of patients with brain abscess to identify Enterococcus as a causative organism. Results: 12 patients (nine males) were diagnosed to have enterococcal brain abscess. All were due to E. species. All were due to E. species. Conclusions: The clinical feature and management are not different from other etiological agents. The prognosis of enterococcal brain abscess is more favourable than bacteremia.
Clinical spectrum and radiographic features of the syndrome of the trephined
Authors: Sedney Cara L. , Dillen William , Julien Terrence 
Published: June 2015

ABSTRACT
Object: Craniectomy is a common neurosurgical procedure. Syndrome of the trephined (ST) occurring after craniectomy results in neurologic symptoms that are reversible with cranioplasty. While well-documented, previous literature consisted of case reports, symptom spectrum and risk factors have not been well characterized. Materials and Methods: A retrospective review of 29 consecutive cases who underwent decompressive craniectomy within a 30-month period was performed. Patients were considered affected by ST if a previously stable neurological deficit improved within 3 weeks after cranioplasty. Prevalence of ST was measured and association with demographic information, clinical symptoms patterns, indication for and size of craniectomy, as well as radiological signs were tested. Results: Seven patients (24%) developed ST. Chronic rehabilitation arrest was more common than acute neurologic decline. Factors such as craniectomy size and patient age did not reach statistical significance in development of ST. Radiographic factors were predictive, with a sunken skin flap contour being most sensitive, while ventricular effacement was most specific.Conclusion: ST may have a higher incidence than previously thought, with a chronic rehabilitation arrest being a more common presentation than an acute decline. Medical providers involved in the post surgical care and rehabilitation of these patients should maintain a high index of suspicion for ST.
Primary angiitis of central nervous system: The story of a great masquerader
Authors: Bajaj Bhupender , Pandey Shweta , Ramanujam Bhargavi , Wadhwa Ankur 
Published: June 2015

ABSTRACTPrimary angiitis of central nervous system (PACNS) is characterized by non-caseating granulomatous angiitis restricted to CNS. The condition often masquerades as migraine, stroke, epilepsy, dementia, demyelinating disorder and CNS infection. The protean manifestations frequently lead to misdiagnoses. We present a case of a young male from rural background that remained undiagnosed for years as the possibility of PACNS was not considered. He had history suggestive of migraine-like headaches followed by seizures. Subsequently, he developed rapidly progressive dementia and two episodes of hemorrhagic strokes over a short period. The diagnosis was finally clinched by the absence of evidence of systemic vasculitis and the presence of characteristic non-caseating granuloma around vessels of duramater and cerebral parenchyma on brain biopsy. He was started on pulse therapy with intravenous cyclophosphamide and methylprednisolone. The current literature about the condition and its management is reviewed in this report.
Hypnic jerks possibly induced by escitalopram
Authors: Sathe Harshal , Karia Sagar , Desousa Avinash , Shah Nilesh 
Published: June 2015

ABSTRACTHypnic jerks or sleep starts are benign myoclonic jerks that usually occur on falling asleep. Various factors like excessive caffeine intake, physical, and emotional stress can increase their frequency. Here we report a case of a female who suffered from hypnic jerks with use of selective serotonin reuptake inhibitor drug escitalopram and responding to treatment with clonazepam.
Calf heads on a trophy sign: Miyoshi myopathy
Authors: Shyma M. Mundayadan , Roopchand P. Sreedharan , Ram K. Mohan , Shaji C. Velayudhan 
Published: June 2015

ABSTRACTMiyoshi myopathy is an autosomal recessive distal myopathy with predominant involvement of the posterior calf muscles attributed to mutations in the dysferlin gene. We report a 26-year-old male, born of nonconsanginous parentage. He noticed weakness and atrophy of leg muscles with inability to walk on his heels. The creatine kinase concentration was high. The electromyography showed myopathic pattern and the muscle biopsy disclosed dystrophic changes with absence of dysferlin. Miyoshi myopathy may be distinct among the hereditary distal myopathies. There are only few reported cases of Miyoshi myopathy in the world literature. In India only 12 cases were reported who had classical features of Miyoshi myopathy. Our’s is a typical case of Miyoshi myopathy, with an affected twin sister as well. He also had “calf heads on a trophy sign” on physical examination, which is considered to be pathognomonic of this disease.
Antischistosomal Activity of Two Active Constituents Isolated from the Leaves of Egyptian Medicinal Plants
Authors: Ali Sanaa A. , El-Regal Nagy S. , Saeed Samar M. 
Published: June 2015

Highlights D-mannitol, a naturally occurring sugar isolated from the leaves Ixora undulata Roxb., and a linear chain pectin homogalacturonan (HG) polysaccharide isolated from the leaves of Linum grandiflorum Desf. (scarlet flax) were evaluated for their therapeutic effect against schistosomiasis with biochemical and histochemical evaluations, and compared with the reference drug praziquantel, to assess the antioxidant and antischistosomal effects of D-mannitol and pectin. In this paper, we investigate the role of two active constituents isolated from the leaves of Egyptian medicinal plants. D-mannitol a naturally occurring sugar isolated from the leaves Ixora undulata Roxb., and the pectin a linear chain homogalacturonan (HG) polysaccharide isolated from the leaves of Linum grandiflorum Desf. (scarlet flax). Both are evaluated for their therapeutic effect against schistosomiasis with biochemical and histochemical evaluations and compared with praziquantel, a reference drug. Biochemical studies of hepatic glucose, the glycogen content, and total serum protein were carried out, and histochemical evaluations through serum protein fractions separated by polyacrylamide gel electrophoresis with different molecular weights (260–10 kDa) were made in all groups, in addition to liver and body weight. D-mannitol and pectin show a remarkable effect in enhancing liver and kidney functions through enhancing most protein fractions in the serum of mice infected with Schistosoma mansoni. Also, the glucose and glycogen content in injured liver tissues improved, in addition liver and body weight in the infected groups. Thus they may be of therapeutic potential in the treatment hepatoxicity and nephrotoxicity.
A Geometric Extension of Schwarz’s Lemma and Applications
Authors: Cleanthous Galatia 
Published: June 2015

Abstract
Let f be a holomorphic function of the unit disc , preserving the origin. According to Schwarz’s Lemma, |f'(0)| ≤ 1, provided that . We prove that this bound still holds, assuming only that f() does not contain any closed rectilinear segment [0, eiϕ], ϕ ∊ [0, zπ], i.e., does not contain any entire radius of the closed unit disc. Furthermore, we apply this result to the hyperbolic density and give a covering theorem.
Turismo on line, identidad virtual y explotación sexual
Authors: Castillo Murillejo Norma Constanza , Cárdenas Pinto Guillermo H. , Rodriguez Mercado Humberto 
Published: June 2015

El presente artículo de revisión, ofrece un marco de referencia para la interpretación de los asuntos relacionados con la explotación sexual en el contexto de viajes y turismo. Cumple con los propósitos de identificar y establecer relaciones de intertextualidad entre el turismo en línea y la explotación sexual comercial, así como de definir categorías de análisis útiles para la interpretación de ambos fenómenos. Para lograrlo, hace visible el proceso de construcción de la identidad virtual que sucede durante la interacción entre usuarios de redes y consumidores de medios. A partir del diálogo establecido entre autores consultados, se “fue hilando fino” en los tres campos de estudio que se definieron –Turismo on line, identidad virtual y explotación sexual– realizando así, la sistematización de conocimientos fragmentados que permitan contestar ¿qué estrategias comunicativas turísticas implícitas utilizadas por internet facilitan la explotación de niños, niñas y adolescentes en el contexto de viajes y turismo?
Prevalence and Risk Profile Of Unread Messages To Patients In A Patient Web Portal
Authors: Mostaghimi A. , O’Brien J. , Bajracharya A. , Safran C. , Landon B.E. , Crotty B.H. 
Published: June 2015

Summary
Background: Excitement around the adoption of electronic communication between physicians and patients is tempered by the possibility of increased clinical and legal risk. If patients do not read messages in a timely fashion, duplicative communication efforts may be required and patient safety may be jeopardized.
Objective: We sought to assess the prevalence and risk profile of unread messages in a mature patient portal.
Methods: We analyzed six years of messages (2005–2010) from physicians to patients to determine the prevalence and associated characteristics of unread messages in a patient portal. We focused on clinical messages, and excluded announcements. Because some physicians sent clinical messages to groups of patients, we labeled messages sent to more than 5 patients as “outreach” messages and excluded them from general analyses. We performed a chart review of 75 clinical messages to assess for harm.
Results: We found that 3% of clinical messages were unread after 21 days. Messages arriving outside of business hours were slightly more likely to go unread (RR 1.15 95% CI 1.11–1.19). Patients who were male (OR 1.14 CI 1.04–1.26) African American (OR 1.69 CI 1.29–2.22) or Hispanic (OR 1.74 CI 1.17–2.59), or in the lowest income group (OR 1.72 CI 1.19–2.49) were more likely to have unread messages. Chart review showed no evidence of harm, but 13% of sampled unread messages were associated with potential delays in care. Incidentally, we found 50% of the physician-initiated outreach messages were unread.
Conclusions: Overall, secure messaging appears a safe form of communication, but systems to notify senders when messages are unread may have value. While most clinical messages were read, many outreach messages were not, providing caution for relying on such systems for information dissemination. Similar to other studies, differences by race and income were observed and require further study.
Citation: Crotty BH, Mostaghimi A, O’Brien J, Bajracharya A, Safran C, Landon B. Prevalence and Risk Profile Of Unread Messages To Patients In A Patient Web Portal. Appl Clin Inf 2015; 6: 375–382http://dx.doi.org/10.4338/ACI-2015-01-CR-0006
The Impact of Expasyl® Gingival Retraction Paste on the Bond Strength of Self-etch and Total-etch Systems
Authors: Ahmad Zeeshan H , Anil Sukumaran , Araby Alaa El , Amri Mohammad D Al 
Published: June 2015

ABSTRACT

Objective
To evaluate the influence of Expasyl® gingival retraction paste on the shear bond strength of self-etch and total-etch adhesive systems.

Materials and methods
Twenty-four specimens of extracted, caries-free, sound human molars were used in this study. The molars were then cut vertically into halves through the buccal and lingual cusps. Forty-eight specimens were divided into four groups (total-etch, total-etch with Expasyl application, self-etch, self-etch with Expasyl application) and the shear bond strength was tested.

Results
Expasyl significantly reduced the shear bond strength of the self-etch and total-etch adhesive systems. The self-etch system showed relatively lower performance compared with the total-etch adhesive system. The shear bond strength values of the total-etch adhesive without Expasyl showed the highest bond strength (21.48 ± 2.89), while the self-etching group adhesive treated with Expasyl showed the lowest shear bond strength value (14.89 ± 1.81).

Conclusion
From the observations of this in vitro study, it can be concluded that the use of Expasyl® gingival retraction system can negatively affect bond strength of adhesives. The total-etch system showed better compatibility to the Expasyl gingival retraction system than the self-etch.

How to cite this article
Al Baker AMA, El Araby A, Al Amri MD, Sukumaran A. The Impact of Expasyl® Gingival Retraction Paste on the Bond Strength of Self-etch and Total-etch Systems. J Contemp Dent Pract 2015;16(5):335-339.
Comparison of Canal Transportation, Centering Ratio by Cone-beam Computed Tomography after Preparation with Different File Systems
Authors: Türker Sevinç Aktemur , Uzunoglu Emel 
Published: June 2015

ABSTRACTAimOne Shape Apical 1 (OSA 1) is a new file for preparing the apical aspect of the root canal after One Shape (OS, Micro Mega, Besançon, France). This study compared apical transportation and centering ratios in curved root canals, which were instrumented with ProTaper Next (PTN, Dentsply Tulsa Dental Specialties, Tulsa, OK) up to size X3 and with OS up to OSA 1.Materials and methodsForty-eight mesial canals of mandibular molars were assigned into two groups (n = 24) with respect to canal length and curvature. Root canals were accessed conventionally and preperation was completed with PTN files up to X3 or with OS up to OSA 1 according to the manufacturer's protocols. Apical transportation was assessed pre- and postinstrumentation using cone-beam computed tomographic (CBCT) scans of 1, 2, 3, 4, and 5 mm sections. A Friedman test was performed to assess the significance between file systems.ResultsNo significant difference was found between the file systems regarding apical transportation and centering ratio values (p > 0.05). Transportation in the mesial direction was greater than the distal transportation for both file systems.ConclusionConsidering apical transportation and centering ratio in curved canals, two systems provided similar results.Clinical significancePreparation up to One Shape Apical 1 or ProTaper Next X3 was shown similar results regarding apical transportation and centering ratio. Both systems were safe to use in curved molar root canals.How to cite this articleUzunoglu E, Turker SA. Comparison of Canal Transportation, Centering Ratio by Cone-beam Computed Tomography after Preparation with Different File Systems. J Contemp Dent Pract 2015;16(5):360-365.
Lichenoid Features and Fibrosis: Coexistence in Quid-induced Oral Lesions
Authors: Yanduri Sarita , Kumar Veerendra B , Suma S , Madhura MG 
Published: June 2015

ABSTRACTBackgroundOral submucous fibrosis (OSF) and quid associated oral lichenoid lesions (QOLL) are caused because of areca nut chewing and both show very characteristic histological changes. The present study aims to determine the histopathological presence of lichenoid features in cases of OSF as well as to determine the presence of fibrosis in cases of QOLL.Materials and methodsThe study involved the retrospective analysis of hematoxylin and eosin stained slides of OSF (n = 50) and QOLL (n = 16).ResultsSeven cases of OSF revealed histopathological features of lichenoid reaction and four cases of QOLL revealed the presence of fibrosis in the underlying connective tissue.ConclusionThis study put forths a new finding that is, the presence of concomitant disease processes seen in the same patient at a histological level. It thus, stresses the need to evaluate all cases of OSF and QOLL for additional features which may be induced by areca nut chewing.How to cite this articleYanduri S, Kumar VB, Suma S, Madhura MG. Lichenoid Features and Fibrosis: Coexistence in Quid-induced Oral Lesions. J Contemp Dent Pract 2015;16(5):389-393.
Le concept de "hantises": de Derrida à Ricoeur (et retour)
Authors: Stavo-Debauge Joan 
Published: June 2015

Cet article considère l’utilisation du concept de « hantise » chez Derrida et Ricœur. Commençant par l’usage du concept par Derrida dans Spectre de Marx, l’article vient ensuite sur la façon dont Ricœur dessine deux usages distincts du même concept dans La mémoire, l’histoire et l’oubli et dans Parcours de la reconnaissance. Après avoir évalué les différents usages de ce concept dans le travail de Ricœur, l’article propose une nouvelle compréhension de ce phénomène de la "hantise", à l’horizon de son utilisation par les sciences sociales et historiques.
Engine Of Innovation: Building the High Performance Catalog
Authors: Owen Will , Michalak Sarah C. 
Published: June 2015

Numerous studies have indicated the sophisticated web-based search engines have eclipsed the primary importance of the library catalog as the premier tool for researchers in Higher education. We submit that the catalog remains central to the research process. Through a series of strategic enhancements, the University of North Carolina at Chapel Hill, in partnership with the other members of the Triangle Research Libraries Network, has made the catalog a carrier of services in addition to bibliographic data, facilitating not simply discovery but also delivery of the information researchers seek.
Quelles utilisations des images de l’exposition sur les sites Internet de musées ? Congruence et incohérence entre objets et images numériques
Authors: Sandri Eva 
Published: June 2015

Dans cet article, l’auteure observe la relation entre les objets d’une collection muséale tels qu’ils sont disposés dans l’exposition et tels qu’ils sont valorisés sur les sites Internet des institutions muséales. L’objectif étant d’évaluer le degré de congruence entre ces deux lieux, il s’agira de comparer les deux médias que sont l’exposition et le site Internet afin de mettre au jour la relation qui les unit et de comprendre s’il y a un rapport de subordination ou de complémentarité entre les deux. Cette analyse sera menée à l’aide des outils descriptifs du webdesign avec les exemples de trois institutions muséales visitées en mai 2013 : Boréalis Centre d’histoire de l’industrie papetière de Trois-Rivières, le Centre d’histoire de Montréal et le musée Grévin de Montréal. À travers l’analyse de la place des substituts numériques de ces objets sur les sites Internet de ces institutions se dessine une typologie de ces sites : ceux qui expliquent l’image et ceux qui donnent simplement à voir le lieu d’exposition. On observera que la majorité des sites Internet étudiés n’accordent pas une place centrale à leurs objets de collection. Le contenu des sites semble davantage focalisé sur l’évocation du lieu et les informations pratiques. Il y aurait donc un décalage dans la façon dont les objets de musée (notamment des musées d’histoire et d’ethnographie) sont exposés dans les deux médias. En outre, cette circulation de l’objet de collection entre le statut d’expôt, de document, de source et d’oeuvre, complexifie la mise en place d’un site Internet qui distingue clairement ce qui relève de la collection et ce qui relève de la description de la collection. À l’heure où le document et l’archive tendent à faire partie des collections, les sites Internet observés rendent compte de cette indécision. En observant le parti pris de ces sites, on remarque que les images numériques montrent les lieux de l’exposition (notamment l’organisation spatiale de l’espace) plus que leurs objets.