bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of surface glycoconjugates inLeishmaniamidgut attachment examined by competitive binding assays and experimental development in sand flies
Authors: JECNA LUCIE , DOSTALOVA ANNA , WILSON RAY , SEBLOVA VERONIKA , CHANG KWANG-POO , BATES PAUL A. , VOLF PETR 
Published: April 2013

SUMMARYBinding of promastigotes to the sand fly midgut epithelium is regarded as an essential part of theLeishmanialife cycle in the vector. AmongLeishmaniasurface molecules putatively involved in attachment to the sand fly midgut, two GPI-anchored molecules are the most prominent: lipophosphoglycan (LPG) and promastigote surface protease gp63. In this work, we examined midgut attachment ofLeishmanialines mutated in GPI-anchored molecules and compared results from 2 different techniques:in vivodevelopment in sand flies andin vitrocompetitive binding assays using fluorescently labelled parasites. In combination with previous studies, our data provide additional support for (1) an LPG-independent parasite-binding mechanism ofLeishmania majorwithin the midgut of the permissive vectorPhlebotomus perniciosus, and provide strong support for (2) the crucial role ofL. majorLPG in specific vectorPhlebotomus papatasi, and (3) a role forLeishmania amazonensisgp63 inLutzomyia longipalpismidgut binding. Moreover, our results suggest a critical role for GPI-anchored proteins and gp63 inLeishmania mexicanaattachment toL. longipalpismidguts, as the wild type (WT) line accounted for over 99% of bound parasites.
Sociodemographic, psychiatric and somatic risk factors for suicide: a Swedish national cohort study
Authors: Crump C. , Sundquist K. , Sundquist J. , Winkleby M. A. 
Published: April 2013

BackgroundMore effective prevention of suicide requires a comprehensive understanding of sociodemographic, psychiatric and somatic risk factors. Previous studies have been limited by incomplete ascertainment of these factors. We conducted the first study of this issue using sociodemographic and out-patient and in-patient health data for a national population.MethodWe used data from a national cohort study of 7140589 Swedish adults followed for 8 years for suicide mortality (2001–2008). Sociodemographic factors were identified from national census data, and psychiatric and somatic disorders were identified from all out-patient and in-patient diagnoses nationwide.ResultsThere were 8721 (0.12%) deaths from suicide during 2001–2008. All psychiatric disorders were strong risk factors for suicide among both women and men. Depression was the strongest risk factor, with a greater than 15-fold risk among women or men and even higher risks (up to 32-fold) within the first 3 months of diagnosis. Chronic obstructive pulmonary disease (COPD), cancer, spine disorders, asthma and stroke were significant risk factors among both women and men (1.4–2.1-fold risks) whereas diabetes and ischemic heart disease were modest risk factors only among men (1.2–1.4-fold risks). Sociodemographic risk factors included male sex, unmarried status or non-employment; and low education or income among men.ConclusionsAll psychiatric disorders, COPD, cancer, spine disorders, asthma, stroke, diabetes, ischemic heart disease and specific sociodemographic factors were independent risk factors for suicide during 8 years of follow-up. Effective prevention of suicide requires a multifaceted approach in both psychiatric and primary care settings, targeting mental disorders (especially depression), specific somatic disorders and indicators of social support.
Transcending objectivism, subjectivism, and the knowledge in-between: the subject in/of ‘strong reflexivity’
Authors: HAMATI-ATAYA INANNA 
Published: April 2013

AbstractThis article addresses theproblématiqueof the subject and the subject-object dichotomy from a post-objectivist, reflexivist perspective informed by a ‘strong’ version of reflexivity. It clarifies the rationale and epistemic-ontological requirements of strong reflexivity comparatively, through a discussion of autoethnography and autobiography, taken as representatives of other variants of reflexive scholarship. By deconstructing the ontological, epistemic, and reflexive statuses of the subject in the auto-ethnographic and auto-biographical variants, the article shows that the move from objectivism to post-objectivism can entail different reconfigurations of the subject-object relation, some of which can lead to subjectivism or an implicit positivist view of the subject. Strong reflexivity provides a coherent and empowering critique of objectivism because it consistently turns the ontological fact of the social situatedness of knowledge into an epistemic principle of social-scientific research, thereby providing reflexivist scholars with a critique of objectivism from within that allows them to reclaim the philosophical, social, and ethical dimensions of objectivity rather than surrender them to the dominant neopositivist tradition.
X-ray powder diffraction data for [Ru(II) Cl η -6-p-cymene (1R,2R)-N-[((1R,2R)-7,7-dimethyl-2-hydroxy-bicyclo-[2.2.1]- heptan-1-yl)-methansulphonyl]-1,2-diphenylethylene-1,2-diamine] complex
Authors: Pažout R. , Maixner J. , Přech J. , Kačer P. 
Published: April 2013

X-ray powder diffraction data, unit-cell parameters, and space group for a new Ru Cl diamide complex, C36H48N2SO3RuCl, are reported [a = 12.487(4) Å, b = 16.624(5) Å, c = 17.230(3) Å, unit-cell volume V = 3576,79 Å3, Z = 4, and space group P212121]. All measured lines were indexed and are consistent with the P212121 space group. No detectable impurity was observed.
Outcome and patient-reported toxicity in localised prostate cancer treated with dose-escalated hypofractionated intensity-modulated radiotherapy
Authors: Thomson David , Merrick Sophie , Swindell Ric , Wylie James , Cowan Richard , Elliott Tony , Logue John , Livsey Jacqueline , Choudhury Ananya 
Published: April 2013

AbstractObjectiveTo report outcomes and late toxicity for a hypofractionated dose-escalated radiotherapy schedule in patients treated using intensity-modulated radiotherapy (IMRT) for localised prostate cancer.Materials and methodsEighty-eight men with localised prostate cancer were treated with 57 Gy in 19 daily fractions over 4 weeks. A total of 70 out of 88 had high-risk disease. Overall survival, cause-specific survival and biochemical progression-free survival (bPFS, Phoenix definition) were reported. Toxicity was measured retrospectively using Radiation Therapy Oncology Group (RTOG) criteria and assessed prospectively with a validated Late Effects in Normal Tissues Subjective, Objective, Management and Analytic (LENT/SOMA) patient questionnaire.ResultsAt 5 years, overall survival was 84%, cause-specific survival 88% and bPFS 65%. In patients with high-risk disease, 5-year bPFS was 62%. There was no RTOG toxicity above grade III. LENT/SOMA questionnaires were returned by 74% patients. Median scores for bowel and urinary function were <1. Maximum bowel and urinary toxicity scores ≥2 were reported by 64% and 59% of patients, respectively. The median score for sexual function was 1·5, but nearly all (96%) patients recorded a toxicity score ≥2 for at least one question.ConclusionsDose-escalated hypofractionated radiotherapy delivered using IMRT has promising outcomes and acceptable late toxicity. This fractionation schedule is being compared with conventional treatment within an on-going multicentre phase III clinical trial.
Miniature single-sideband subharmonically-pumped 60 GHz direct upconverter in a uniplanar GaAs pHEMT technology using inductive and capacitive loading techniques
Authors: Hettak Khelifa , Ross Tyler N. , Irfan Nazish , Cormier Gabriel , Yagoub Mustapha C. E. , Morin Gilbert A. , Wight Jim S. 
Published: April 2013

This paper presents a novel, compact, single-sideband (SSB) subharmonically-pumped (SHP) direct upconverter developed in a uniplanar 0.18 μm GaAs technology. A total of 100 MHz in-phase and quadrature signals directly modulate the second harmonic of a 30 GHz carrier signal, producing a 60.1 GHz output. Two pairs of antiparallel diodes reduce feed-through of the 30 GHz local oscillator (LO) signal to the mixer's RF output. Novel structures patterned in the center conductor of a coplanar waveguide (CPW) provide matching and size-reduction simultaneously. The 2.1mm2 circuit also uses a miniaturized Wilkinson divider based on asymmetric coplanar stripline and a standard CPW 90° coupler. The SSB SHP direct upconverter exhibits a conversion loss of 10 dB, a lower-sideband rejection of 15 dB and 2fLO suppression of approximately 25 dB over a wide frequency range from 52–61 GHz.
MEMS reconfigurable millimeter-wave surface for V-band rectangular-waveguide switch
Authors: Baghchehsaraei Zargham , Shah Umer , Åberg Jan , Stemme Göran , Oberhammer Joachim 
Published: April 2013

This paper presents for the first time a novel concept of a microelectromechanical systems (MEMS) waveguide switch based on a reconfigurable surface, whose working principle is to block the wave propagation by short-circuiting the electrical field lines of the TE10 mode of a WR-12 rectangular waveguide. The reconfigurable surface is only 30 µm thick and consists of up to 1260 micromachined cantilevers and 660 contact points in the waveguide cross-section, which are moved simultaneously by integrated MEMS comb-drive actuators. Measurements of fabricated prototypes show that the devices are blocking wave propagation in the OFF-state with over 30 dB isolation for all designs, and allow for transmission of less than 0.65 dB insertion loss for the best design in the ON-state for 60–70 GHz. Furthermore, the paper investigates the integration of such microchips into WR-12 waveguides, which is facilitated by tailor-made waveguide flanges and compliant, conductive-polymer interposer sheets. It is demonstrated by reference measurements where the measured insertion loss of the switches is mainly attributed to the chip-to-waveguide assembly. For the first prototypes of this novel MEMS microwave device concept, the comb-drive actuators did not function properly due to poor fabrication yield. Therefore, for measuring the OFF-state, the devices were fixated mechanically.
Pandora's box? Drone strikes underjus ad bellum, jus in bello, and international human rights law
Authors: Casey-Maslen Stuart 
Published: April 2013

AbstractArmed drones pose a major threat to the general prohibition on the inter-state use of force and to respect for human rights. On the battlefield, in a situation of armed conflict, the use of armed drones may be able to satisfy the fundamental international humanitarian law rules of distinction and proportionality (although attributing international criminal responsibility for their unlawful use may prove a significant challenge). Away from the battlefield, the use of drone strikes will often amount to a violation of fundamental human rights. Greater clarity on the applicable legal regime along with restraints to prevent the further proliferation of drone technology are urgently needed.
The Spanish Guitar in the Newspapers, Novels, Drama and Verse of Eighteenth-Century England
Authors: Page Christopher 
Published: April 2013

For Paul SparksFor the most part, the history of the Spanish guitar in eighteenth-century England seems to be no history at all. There appears to be little to place between Samuel Pepys and the beginning of the nineteenth century when the six-string guitar emerged as a favoured instrument of the parlour musician. Thus it is widely supposed that the gut-strung guitar was little used in England until Fernando Sor and other foreign players made it fashionable in the decades after Waterloo (1815). This article proposes to correct that deeply entrenched view with a chronological checklist of material, much of it presented in this connection for the first time, that illuminates the fortunes of the guitar in eighteenth-century England, principally London.
Automated annotation and quantification of glycans using liquid chromatography–mass spectrometry
Authors: Yu Chuan-Yih , Mayampurath Anoop , Hu Yunli , Zhou Shiyue , Mechref Yehia , Tang Haixu 
Published: April 2013

Abstract
Summary: As a common post-translational modification, protein glycosylation plays an important role in many biological processes, and it is known to be associated with human diseases. Mass spectrometry (MS)-based glycomic profiling techniques have been developed to measure the abundances of glycans in complex biological samples and applied to the discovery of putative glycan biomarkers. To automate the annotation of glycomic profiles in the liquid chromatography-MS (LC–MS) data, we present here a user-friendly software tool, MultiGlycan, implemented in C# on Windows systems. We tested MultiGlycan by using several glycomic profiling datasets acquired using LC–MS under different preparations and show that MultiGlycan executes fast and generates robust and reliable results.
Availability: MultiGlycan can be freely downloaded at http://darwin.informatics.indiana.edu/MultiGlycan/.
Contact: chuyu@indiana.edu or hatang@indiana.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Value of N‐terminal pro brain natriuretic peptide levels in different types of Fontan circulation
Authors: Heck Pinar Bambul , Müller Jan , Weber Ruth , Hager Alfred 
Published: April 2013

AimsN‐terminal pro brain natriuretic peptide (NT‐proBNP) is an important biomarker in congestive heart failure. This has also been confirmed in congenital heart disease. However, its clinical value in patients with different types of Fontan circulation remains questionable.Methods and resultsWe prospectively analysed 124 patients with various types of Fontan surgery between October 2006 and February 2011. We included 49 patients with older Fontan modification [atriopulmonary connection (APC) and atrioventricular connection (AVC)] and 75 patients with total cavopulmonary connection (TCPC). The NT‐proBNP levels of patients with APC/AVC were significantly higher than in patients with TCPC (P < 0.001), even after accounting for sex, age, ventricular function, atrioventricular regurgitation, ventricular morphology, and arrhythmia (P = 0.035). Levels of NT‐proBNP positively correlated with atrioventricular valve regurgitation (r = 0.29, P = 0.013) and ventricular dysfunction (r = 0.23, P = 0.052) only in patients with TCPC, but not in patients with APC or AVC (r = 0.01, P = 0.509 and r = 0.10, P = 0.493, respectively).ConclusionLevels of NT‐pro BNP are related to the type of Fontan circulation. The older types (APC/AVC) that involve more atrial tissue in the systemic venous pathway show higher NT‐proBNP levels independently of their cardiac status. Their NT‐proBNP levels should be interpreted with care.
Rousseau and the Reserve of Nature: A Rejoinder to Derrida
Authors: Di Palma Marco Michael 
Published: April 2013

Abstract

This article re-examines Derrida's presentation of Rousseau's philosophy of nature and culture in
De la grammatologie
to interrogate that work's conclusions about the inescapability of the logic of the
supplément
. Drawing on a close reading of the first book of
Émile
, it argues that Rousseau's ontological commitments neither originate from nor entail a metaphysics of pure presence. The challenge to Derrida derives from the category of habit understood as an ontological principle that structures the conceptualization of nature in
Émile
. Rousseau's formulation of nature as a
réserve
, a theory of innateness as sleeping potentiality, indicates not a ‘presence’ but a store of potencies bearing an indeterminate ontology. As well as a capacity and an agency, nature is also a state of being. Habit, meanwhile, reveals the two senses of nature — as teleology and being — and mediates between them. Nature, for its part, arises as the outcome, as well as the origin and determination, of habit. This signifies that nature and culture are not the terms of a dichotomy but arise simultaneously when habit draws from nature's reserve. The article concludes that Derrida simplifies and exploits Rousseau by reading him through the distorting lens of Lévi-Strauss's structuralist anthropology.
REGRESSION OF TAKAYASU RETINOPATHY AFTER REVASCULARIZATION OF OCCLUDED BRANCHES OF THE AORTIC ARCH BY PERCUTANEOUS ANGIOPLASTY
Authors: Peter Jayanthi , Joseph George , David Sarada , Danda Debashish 
Published: April 2013

Purpose:
To present a patient with decreased vision because of Takayasu retinopathy who had improvement in vision and regression of retinopathy after percutaneous angioplasty of occluded aortic arch vessels.

Methods:
Interventional case report.

Results:
A 37-year-old woman with multiple cerebral infarcts and recurrent seizures was referred with painless progressive reduction in vision in the right eye of few months’ duration and left eye for 2 years. Vision was 20/120 in the right eye and perception of light in the left eye. There was mild disk pallor in the right eye, optic atrophy in the left eye, and microaneursyms in both eyes. Angiographic findings were consistent with type I Takayasu arteritis. Angioplasty and stenting was performed initially to the right subclavian and common carotid arteries and to the left subclavian, and left internal carotid arteries 6 weeks later. There was improvement in vision to 20/80 and regression of Takayasu retinopathy in the right eye at 3 months post procedure that improved further to 20/50, 6 months post procedure. Vision, as expected, remained poor in the left eye despite revascularization.

Conclusion:
Restoration of flow in the aortic arch vessels may result in reversal of ischemic retinal changes in patients with Takayasu retinopathy.
Using Arabidopsis to Study Shoot Branching in Biomass Willow
Authors: Ward Sally P. , Salmon Jemma , Hanley Steven J. , Karp Angela , Leyser Ottoline 
Published: April 2013

AbstractThe success of the short-rotation coppice system in biomass willow (Salix spp.) relies on the activity of the shoot-producing meristems found on the coppice stool. However, the regulation of the activity of these meristems is poorly understood. In contrast, our knowledge of the mechanisms behind axillary meristem regulation in Arabidopsis (Arabidopsis thaliana) has grown rapidly in the past few years through the exploitation of integrated physiological, genetic, and molecular assays. Here, we demonstrate that these assays can be directly transferred to study the control of bud activation in biomass willow and to assess similarities with the known hormone regulatory system in Arabidopsis. Bud hormone response was found to be qualitatively remarkably similar in Salix spp. and Arabidopsis. These similarities led us to test whether Arabidopsis hormone mutants could be used to assess allelic variation in the cognate Salix spp. hormone genes. Allelic differences in Salix spp. strigolactone genes were observed using this approach. These results demonstrate that both knowledge and assays from Arabidopsis axillary meristem biology can be successfully applied to Salix spp. and can increase our understanding of a fundamental aspect of short-rotation coppice biomass production, allowing more targeted breeding.
Long distance autonomous trajectory tracking for an orchard vehicle
Authors: Bayar Gokhan 
Published: April 2013

PurposeThe purpose of this paper is to present work which is a part of the Comprehensive Automation for Specialty Crops project (CASC). Desired trajectory tracking objective has been previously performed by using a non‐model based approach in this project. Long distance autonomous drive has been achieved; however the results haven't met the expectations of the project requirements. In order to provide these requirements, this study is conducted. In this study, long distance autonomous trajectory tracking for an orchard vehicle is studied. Besides longitudinal motion, lateral motion of the vehicle is also considered. The longitudinal and lateral errors are objected to keep into a region of less than 10 cm.Design/methodology/approachCar‐like robot kinematic modeling approach is used to create desired trajectory. In order to control longitudinal velocity and steering angle of the vehicle, a controller methodology is proposed. Stability of the controller proposed is shown by using Lyapunov stability approach.FindingsThe proposed model is adapted into a four‐wheeled autonomous orchard vehicle and tested in an experimental orchard for long distance autonomous drives. More than 15 km autonomous drive is successfully achieved and the details are presented in this paper.Originality/valueIn this study, long distance autonomous trajectory tracking for an orchard vehicle is focused. A model based control strategy, including the information about longitudinal and lateral motion of the vehicle, is constructed. A new approach to create steering angles for turning operations of the orchard vehicle is introduced. It is objected that the longitudinal and lateral errors should be less than 10 cm during the trajectory tracking task.
Users' attitudes toward service robots in South Korea
Authors: Park Eunil , del Pobil Angel P. 
Published: April 2013

PurposeThe purpose of this paper is to understand users' acceptance of service robots by integrating perceived enjoyment of service robots and users' need to belong in a technology acceptance model (TAM) framework. Service robots are currently being used in homes and firms to provide various services.Design/methodology/approachThe authors conducted a web‐based survey from 904 users in South Korea to test a research model and employed structural equation modelling as the analysis method.FindingsThis study found that perceived enjoyment and the need to belong played an important role in the perceived ease of use and usefulness of service robots. Furthermore, it was discovered that the research supported relationships proposed by the original TAM with regard to users' attitudes and intentions to use service robots. Therefore, this study provides a framework to understand users' acceptance of service robots.Originality/valueThis paper is of value to researchers designing and improving service robots for use in our society.
A time‐controllable Allan variance method for MEMS IMU
Authors: Zhao Hongyu , Wang Zhelong , Shang Hong , Hu Weijian , Qin Gao 
Published: April 2013

PurposeThe purpose of this paper is to reduce the calculation burden and speed up the estimation process of Allan variance method while ensuring the exactness of the analysis results.Design/methodology/approachA series of six‐hour static tests have been implemented at room temperature, and the static measurements have been collected from MEMS IMU. In order to characterize the various types of random noise terms for the IMU, the basic definition and main procedure of the Allan variance method are investigated. Unlike the normal Allan variance method, which has the shortcomings of processing large data sets and requiring long computation time, a modified Allan variance method is proposed based on the features of data distribution in the log‐log plot of the Allan standard deviation versus the averaging time.FindingsExperiment results demonstrate that the modified Allan variance method can effectively estimate the noise coefficients for MEMS IMU, with controllable computation time and acceptable estimation accuracy.Originality/valueThis paper proposes a time‐controllable Allan variance method which can quickly and accurately identify different noise terms imposed by the stochastic fluctuations.