bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Facile Synthesis of 2‐Arylphenols via Palladium‐Catalyzed Cross‐Coupling of Aryl Iodides with 6‐Diazo‐2‐cyclohexenones.
Authors: Yang Ke , Zhang Jun , Li Yun , Cheng Bin , Zhao Liang , Zhai Hongbin 
Published: June 2013

AbstractThe new approach for the synthesis of a wide range of the title compounds is developed.
ChemInform Abstract: Palladium‐Supported Hybrid Cellulose—Aluminum Oxide Composite for Suzuki—Miyaura Cross‐Coupling Reaction.
Authors: Kumbhar Arjun , Jadhav Sanjay , Kamble Santosh , Rashinkar Gajanan , Salunkhe Rajashri 
Published: June 2013

AbstractThe robust catalyst allows the synthesis of various biphenyls from aryl bromides in an aqueous medium.
ChemInform Abstract: Alkenylation of 1‐ and 2‐Naphthols by Using Magnesium Alkylidene Carbenoids as Electrophilic Alkenylating Agents.
Authors: Kimura Tsutomu , Watanabe Masaya , Kashiwamura Gaku , Sakurada Jo , Satoh Tsuyoshi 
Published: June 2013

AbstractThe procedure provides various C‐alkenylated naphthols regioselectively.
ChemInform Abstract: Asymmetric Synthesis of trans‐Dihydroarylfurans in a Friedel—Crafts/Substitution Domino Reaction under Squaramide Catalysis.
Authors: Jarava‐Barrera Carlos , Esteban Francisco , Navarro‐Ranninger Carmen , Parra Alejandro , Aleman Jose 
Published: June 2013

AbstractEnantiopure trans‐dihydroarylfurans (II), (V) and (VII) are synthesized from (Z)‐bromonitroalkenes (II) and naphthol (I) or phenol derivatives (IV) and (VI), resp., in good yields and high enantioselectivity by using a squaramide catalyst.
ChemInform Abstract: (.+‐.)‐CSA‐Catalyzed Friedel—Crafts Alkylation of Indoles with 3‐Ethoxycarbonyl‐3‐hydroxyisoindolin‐1‐one: An Easy Access of 3‐Ethoxycarbonyl‐3‐indolylisoindolin‐1‐ones Bearing a Quaternary α‐Amino Acid Moiety.
Authors: Srivastava Anvita , Singh Shivendra , Samanta Sampak 
Published: June 2013

AbstractThe approach is advantageous with regards to simple operation, mild conditions, and high yields.
ChemInform Abstract: Unexpected Formation of Pyrrolo[1,2‐a]quinoxaline Derivatives During the Multicomponent Synthesis of Pyrrolo[1,2‐a]benzimidazoles.
Authors: Nicolescu Alina , Deleanu Calin , Georgescu Emilian , Georgescu Florentina , Iurascu Ana‐Maria , Shova Sergiu , Filip Petru 
Published: June 2013

AbstractThree‐component reaction of N‐benzylbenzimidazole (I), α‐bromoacetophenones and carbonyl‐activated alkynes gives pyrrolobenzimidazoles (IV) in refluxing 1,2‐epoxybutane.
ChemInform Abstract: Stereochemical Control on the Michael Addition of Chiral 1,3‐Oxazolidine‐2‐thiones to N‐Crotonyl 1,3‐Oxazolidin‐2‐ones.
Authors: Munive Laura , Dzakuma Sena A. , Olivio Horacio F. 
Published: June 2013

AbstractConjugated addition of non‐chiral oxazolidinethione (II) to chiral N‐crotonyl oxazolidinones proceeds with poor diastereoselectivity.
ChemInform Abstract: Enantioselective Construction of Spirooxindole Derivatives Through [3 + 2] Annulation Catalyzed by a Bisthiourea as a Multiple‐Hydrogen‐Bond Donor.
Authors: Shi Yan , Lin Aijun , Mao Haibin , Mao Zhijie , Li Weipeng , Hu Hongwen , Zhu Chengjian , Cheng Yixiang 
Published: June 2013

AbstractThe products with three contiguous stereocenters including one spiroquaternary center are obtained with excellent dia‐ and enantioselectivity.
ChemInform Abstract: Study on the Tandem Synthesis of Optically Active 2‐Substituted 4 (or 5)‐Phenyl‐1,3‐oxazolines.
Authors: Jiang Haizhen , Lu Wenjun , Cai Yeshan , Wan Wen , Wu Shaoxiong , Zhu Shizheng , Hao Jian 
Published: June 2013

AbstractThe proposed mechanism for this reaction involves an aziridine intermediate with the acidities of the carboxylic acids playing a key role in the selective formation of various intermediates.
ChemInform Abstract: Straightforward Method for Regioselective Reduction of 3‐Acyl‐Substituted 2‐(Trifluoromethyl)‐2H‐chromen‐5‐one and Chromane Scaffolds in NaBH4/Ethanol Medium.
Authors: Bonacorso Helio G. , Navarini Jussara , Luz Fabio M. , Whietan Carson W. , Junges Andrizia F. , Cavinatto Susiane , Martins Marcos A. P. , Zanatta Nilo 
Published: June 2013

AbstractReduction of the title 3‐acylchromenones (I) with NaBH4 in EtOH regio‐ and stereoselectively affords 8a‐hydroxyoctahydrochromenones (II).
ChemInform Abstract: Cu‐Mediated Selective O‐Arylation on C‐6 Substituted Pyridin‐2‐ones.
Authors: Chen Taijie , Huang Qingqing , Luo Yu , Hu Youhong , Lu Wei 
Published: June 2013

AbstractOptimized conditions are developed for the Chan—Evans—Lam cross‐coupling of pyridin‐2‐ones with arylboronic acids to yield the O‐arylated products selectively.
ChemInform Abstract: Synthesis of Selective Inhibitors of Sphingosine Kinase 1.
Authors: Baek Dong Jae , MacRitchie Neil , Pyne Nigel J. , Pyne Susan , Bittman Robert 
Published: June 2013

AbstractAmong the novel compounds screened for their inhibitory potency against sphingosine kinase 1, derivative (IIIb) exhibits the highest activity.
ChemInform Abstract: Palladium‐Catalyzed Desulfitative Arylation of 3‐Haloquinolines with Arylsulfinates.
Authors: Colomb Julie , Billard Thierry 
Published: June 2013

AbstractConditions A) are elaborated as the most efficient ones: halogenated nitrogen heteroarenes substituted at the aryl moiety afford moderate to good yields of the desired compounds.
ChemInform Abstract: Carbophilic 3‐Component Cascades: Access to Complex Bioactive Cyclopropyl Diindolylmethanes.
Authors: Groome Nigel M. , Elboray Elghareeb E. , Inman Martyn W. , Dondas H. Ali , Phillips Roger M. , Kilner Colin , Grigg Ronald 
Published: June 2013

AbstractCycloisomerization of nitrogen‐tethered 1,6‐dienynes is catalyzed by PtCl2 and affords the corresponding azabicyclo[4.1.0]hept‐4‐enes [viz.
ChemInform Abstract: Regioselective Bromination of Fused Heterocyclic N‐Oxides.
Authors: Wengryniuk Sarah E. , Weickgenannt Andreas , Reiher Christopher , Strotman Neil A. , Chen Ke , Eastgate Martin D. , Baran Phil S. 
Published: June 2013

AbstractA simple, mild, and scalable method for the title reaction is presented which can also be extended to complex molecules [e.g. the antimalarial agent (XIV)] and the incorporation of chlorine using Bu4NCl [viz.
ChemInform Abstract: Regioisomeric 4‐Amino‐ and 6‐Aminopyrazolo[3,4‐b]pyridines: Synthesis and Structure Determination by NMR Spectroscopy and X‐Ray Diffraction.
Authors: Petrov A. A. , Kasatochkin A. N. , Emelina E. E. , Haukka M. 
Published: June 2013

AbstractHeating 5‐aminopyrazoles (I) with ethoxymethylidenemalononitrile in refluxing MeOH selectively affords 4‐aminopyrazolopyridines (III).
ChemInform Abstract: A New Series of C‐6 Unsubstituted Tetrahydropyrimidines: Convenient One‐Pot Chemoselective Synthesis, Aggregation‐Induced and Size‐Independent Emission Characteristics.
Authors: Zhu Qiuhua , Huang Lan , Chen Zhipeng , Zheng Sichao , Lv Longyun , Zhu Zhibo , Cao Derong , Jiang Huanfeng , Liu Shuwen 
Published: June 2013

AbstractTitle compounds are directly synthesized via a convenient urea‐catalyzed chemoselective multicomponent reaction under mild conditions.
ChemInform Abstract: Electrocatalytic and Chemical Methods in MHIRC Reactions: The First Example of the Multicomponent Assembly of Medicinally Relevant Spirocyclopropylbarbiturates from Three Different Molecules.
Authors: Vereshchagin Anatolii N. , Elinson Michail N. , Dorofeeva Evgeniya O. , Stepanov Nikita O. , Zaimovskaya Tatiana A. , Nikishin Gennady I. 
Published: June 2013

AbstractElectrolysis of barbituric acids, malononitrile and aromatic aldehydes in an undivided cell in the presence of sodium bromide results in a Michael halogenation initiated ring closure (MHIRC) reaction yielding spirocyclopropylbarbiturates (IV).
ChemInform Abstract: Direct Access to Novel Chromeno—Pyrimidine N‐Oxides via Tandem Base‐Catalyzed Double Nucleophilic Addition/Dehydration Reaction.
Authors: Jalli Venkata Prasad , Jaggavarapu Satyanarayana Reddy , Kamalakaran Anand Solomon , Gangisetty Sravan Kumar , Nanubolu Jagadeesh Babu , Gaddamanugu Gopikrishna 
Published: June 2013

AbstractThe process is regioselective to give the target compounds (13 examples) in good yields.
ChemInform Abstract: Catalytic Dehydrogenative Si—N Coupling of Pyrroles, Indoles, Carbazoles as well as Anilines with Hydrosilanes Without Added Base.
Authors: Koenigs C. David F. , Mueller Maria F. , Aiguabella Nuria , Klare Hendrik F. T. , Oestreich Martin 
Published: June 2013

AbstractAn efficient protocol for the base‐free dehydrogenative Si‐N coupling of monohydrosilanes with weakly to moderately nucleophilic NH‐groups is described.
ChemInform Abstract: Cycloaddition of Primary Phosphines to Divinyl Sulfide.
Authors: Gusarova N. K. , Malysheva S. F. , Kuimov V. A. , Belogorlova N. A. , Vashchenko A. V. , Trofimov B. A. 
Published: June 2013

AbstractA preparative procedure for the synthesis of 4‐substituted 1,4‐thiaphosphinanes (III) via radical‐initiated cycloaddition of primary phosphines to divinyl sulfide is developed.
ChemInform Abstract: Synthesis of Azahomosteroid Ring System Through Intramolecular [4 + 2] Cycloaddition of in situ Generated Azaisobenzofuran Intermediates.
Authors: Roy Priyabrata , Mitra Partha , Ghorai Binay Krishna 
Published: June 2013

AbstractThe reaction of the N‐heterocyclic substrates with carbene complex (II) produces azaisobenzofuran intermediates.
ChemInform Abstract: Metal‐Mediated Alkynediol Cycloisomerization: First and Second Generation Formal Total Syntheses of Didemniserinolipid B.
Authors: Das Shyamsundar , Induvadana Boddeti , Ramana C. V. 
Published: June 2013

AbstractA formal total synthesis of didemniserinolipid B (III), a natural serinolipid first isolated from the tunicate Didemnum sp., is developed by employing a regioselective metal‐mediated 6‐endo‐dig alkynol‐cycloisomerization reaction as the key step.
ChemInform Abstract: Green Chemistry: Why and How — For Sustainable Chemical Industry and Environmentally Commendable Civilization
Authors: Patil Harshada I. , Singh Meera C. , Gaikwad Preeti , Lade Kedar S. , Gadhave Nilam A. , Sawant Sanjay D. 
Published: June 2013

AbstractReview: 37 refs.
ChemInform Abstract: Physico‐Chemical Foundations Underpinning Microarray and Next Generation Sequencing Experiments
Authors: Harrison Andrew , Binder Hans , Buhot Arnaud , Burden Conrad J. , Carlon Enrico , Gibas Cynthia , Gamble Lara J. , Halperin Avraham , Hooyberghs Jef , Kreil David P. , et al. et al. 
Published: June 2013

AbstractReview: 92 refs.
ChemInform Abstract: Chromogenic and Fluorogenic Chemosensors and Reagents for Anions. A Comprehensive Review of the Years 2010—2011
Authors: Santos‐Figueroa Luis E. , Moragues Maria E. , Climent Estela , Agostini Alessandro , Martinez‐Manez Ramon , Sancenon Felix 
Published: June 2013

AbstractReview: 359 refs.
Carboligation Reactions Mediated by Benzoylformate Decarboxylase Immobilized on a Magnetic Solid Support
Authors: Tural Bilsen , Tural Servet , Demir Ayhan S. 
Published: June 2013

ABSTRACTIn this study, magnetic nanoparticles (Fe3O4, magnetite) with immobilized metal affinity ligands (MSS) were prepared and characterized by X‐ray diffraction (XRD), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), and vibrating‐sample magnetometer (VSM) methods for purification and immobilization of the histidine‐tagged recombinant benzoylformate decarboxylase (BFD). The MSS support was shown to be eligible for selective binding of HIS‐tagged BFD by SDS‐page analysis. Loading capacity of the MSS support was determined as 43.6 ± 1.1 mg/g. The regeneration ability for protein binding was also studied. An immobilized BFD was tested to catalyze benzoin condensation and representative cross acyloin reaction. Conversion and enantiomeric excess values were comparable with that of free enzyme catalyzed reactions. Chirality 25:415–421, 2013. © 2013 Wiley Periodicals, Inc.
Inhibition of Leishmania infantum Trypanothione Reductase by Azole‐Based Compounds: a Comparative Analysis with Its Physiological Substrate by X‐ray Crystallography
Authors: Baiocco Paola , Poce Giovanna , Alfonso Salvatore , Cocozza Martina , Porretta Giulio Cesare , Colotti Gianni , Biava Mariangela , Moraca Francesca , Botta Maurizio , Yardley Vanessa , Fiorillo Annarita , Lantella Antonella , Malatesta Francesco , Ilari Andrea 
Published: June 2013

AbstractHerein we report a study aimed at discovering a new class of compounds that are able to inhibit Leishmania donovani cell growth. Evaluation of an in‐house library of compounds in a whole‐cell screening assay highlighted 4‐((1‐(4‐ethylphenyl)‐2‐methyl‐5‐(4‐(methylthio)phenyl)‐1H‐pyrrol‐3‐yl)methyl)thiomorpholine (compound 1) as the most active. Enzymatic assays on Leishmania infantum trypanothione reductase (LiTR, belonging to the Leishmania donovani complex) shed light on both the interaction with, and the nature of inhibition by, compound 1. A molecular modeling approach based on docking studies and on the estimation of the binding free energy aided our rationalization of the biological data. Moreover, X‐ray crystal structure determination of LiTR in complex with compound 1 confirmed all our results: compound 1 binds to the T(SH)2 binding site, lined by hydrophobic residues such as Trp21 and Met113, as well as residues Glu18 and Tyr110. Analysis of the structure of LiTR in complex with trypanothione shows that Glu18 and Tyr110 are also involved in substrate binding, according to a competitive inhibition mechanism.
Solution‐Processable Graphene Quantum Dots
Authors: Zhou Xuejiao , Guo Shouwu , Zhang Jingyan 
Published: June 2013

AbstractThis minireview describes recent progress in solution‐processable graphene quantum dots (SGQDs). Advances in the preparation, modification, properties, and applications of SGQDs are highlighted in detail. As one of emerging nanostructured materials, possible ongoing research related to the precise control of the lateral size, edge structure and surface functionality; the manipulation and characterization; the relationship between the properties and structure; and interfaces with biological systems of SGQDs have been speculated upon.
In Vivo Magnetic Resonance Imaging Detection of Paramagnetic Liposomes Loaded with Amphiphilic Gadolinium(III) Complexes: Impact of Molecular Structure on Relaxivity and Excretion Efficiency
Authors: Cittadino Evelina , Botta Mauro , Tei Lorenzo , Kielar Filip , Stefania Rachele , Chiavazza Enrico , Aime Silvio , Terreno Enzo 
Published: June 2013

AbstractThe magnetic resonance imaging (MRI) performance of two liposome formulations incorporating amphiphilic 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA)‐like GdIII complexes has been investigated both in vitro and in vivo. The complexes differ in one donor group of the coordination cage (carboxylate versus carboxoamide), and in the length (C12 versus C18) and the point of attachment of the aliphatic chains to the chelators. The in vitro 1H relaxometric characterisation of the systems, performed with a newly developed relaxation model that takes into account the contributions of the GdIII chelates pointing in‐ and outwards of the liposome, indicates that their efficacy is optimal in the range 0.5–1.5 T. The tetracarboxylic C12‐containing liposomes (LIPO‐GdDOTA(GAC12)2; GA=glutaric acid) are four‐fold more efficient than the monoamide C18‐based analogue (LIPO‐GdDOTAMA(C18)2). Such a difference is also found in vivo at 1 T in a melanoma tumour model on mice. A few hours after intravenous injection, the T1 contrast enhancement in the organs where the nanovesicles typically distribute (liver, spleen, kidneys and tumour) is much higher for LIPO‐GdDOTA(GAC12)2. Interestingly, after about 7 h post‐injection the contrast enhancement observed for the more efficient liposomes decreases rapidly and becomes lower than for LIPO‐GdDOTAMA(C18)2. The relaxometric data and the quantification of the GdIII complexes in the organs, determined ex vivo by inductively coupled plasma mass spectrometry, indicate that: 1) the differences in the contrast enhancement can be attributed to the different rate of water exchange and rotational dynamics of the Gd complexes, and 2) the rapid contrast decrease is caused by a faster clearance of GdDOTA(GAC12)2 from the organs. This is also confirmed by using a newly synthesised amphiphilic cyanine‐based fluorescent probe (Cy5‐(C16)2). As one of the main limitations for the clinical translation of liposomes incorporating amphiphilic imaging agents is related to their very long persistence in the body, the results reported herein suggest that the clearance of the probes can be accelerated, without compromising their role, by a proper selection of the lipophilic portion of the incorporated compound as well as of the ligand site at which the aliphatic tails are linked. Then, GdDOTA(GAC12)2 complex may represent a good candidate for the development of improved MRI protocols based on paramagnetically labelled lipidic nanoparticles.
An enhanced XOR‐based scheme for wireless packet retransmission problem
Authors: Gao Zhenguo , Xiang Weidong , Tan Guozhen , Yao Nianmin , Li Peihua 
Published: June 2013

SUMMARYSolving wireless packet retransmission problem (WPRTP) using network coding (NC) is increasingly attracting research efforts. However, existing NC‐based schemes for WPRTP are with high computational complexity resulting from computation on larger Galois field (GF(2q)), or the solutions on GF(2) found by the schemes are less efficient. In this paper, combining the basic ideas in two existing schemes, denoted as ColorNC and CliqueNC, respectively, we present a new scheme named as ColorCliqueNC. The advantages of ColorCliqueNC include the following: (i) it is suitable for all kinds of WPRTP instances; (ii) it works on GF(2); thus, it is computationally efficient than the schemes working on larger Galois fields; and (iii) the solutions found by ColorCliqueNC usually have fewer packet retransmissions than those by ColorNC and CliqueNC despite that they all work on GF(2). Theoretical analysis indicates that ColorCliqueNC is superior to ColorNC and CliqueNC. Simulation results show that ColorCliqueNC generally outperforms ColorNC and CliqueNC. Compared with ColorNC, ColorCliqueNC can save up to 10% packet retransmissions. Copyright © 2013 John Wiley & Sons, Ltd.
Binge/purge thoughts in nonsuicidal self‐injurious adolescents: An ecological momentary analysis
Authors: Shingleton Rebecca M. , Eddy Kamryn T. , Keshaviah Aparna , Franko Debra L. , Swanson Sonja A. , Yu Jessica S. , Krishna Meera , Nock Matthew K. , Herzog David B. 
Published: June 2013

ABSTRACTObjectiveAdolescents who self‐injure often engage in bingeing/purging (BP). Ecological momentary assessment (EMA) has potential to offer insight into the relationship between self‐injury and BP. The aims of this study were to examine the frequency and context of BP using EMA in a sample of nonsuicidal self‐injurious (NSSI) adolescents.MethodThirty adolescents with a history of NSSI responded to questions regarding self‐destructive thoughts/behaviors using a palm‐pilot device. Descriptive analyses compared thought/behavior contexts during reports of BP and NSSI thoughts/behaviors (occurring together vs. individually).ResultsBP thoughts were present in 22 (73%) participants, occurring on 32% of the person‐days recorded; 59% of these participants actually engaged in BP behavior. Seventy‐nine percent of BP thoughts co‐occurred with other self‐destructive thoughts. Adolescents were more often with friends/peers than alone or with family when having BP thoughts. Worry and pressure precipitated both BP and NSSI thoughts, but perceived criticism and feelings of rejection/hurt were associated more often with BP thoughts than with NSSI thoughts.DiscussionBP thoughts and behaviors were common in this sample, often occurring with other self‐destructive thoughts. Future EMA research is needed to address the function of BP symptoms, the contextual variables that increase risk for BP thoughts, and the factors that predict the transition of thoughts into behaviors in adolescents with and without self‐injury. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:684–689)
Lack of pattern of birth in patients with bulimia nervosa
Authors: Vellisca María Y. , Latorre José I. , Santed Miguel A. , Reales José M. , Orejudo Santos , Cañete Miguel 
Published: June 2013

ABSTRACTObjectiveAn excess of bulimia nervosa (BN) births during the fall has been recently reported, but this finding has not been yet adequately replicated. The purpose of our study was to evaluate the presence of a seasonal birth pattern in a representative clinical sample of women with BN.MethodWe registered the month of birth of 216 female patients who fulfilled all the criteria for BN according to DSM‐IV on admission to a specialized eating disorders service in Spain.ResultsOur analyses showed no significant variation in the season of birth of our BN sample when compared to a general population.DiscussionOur data do not support the hypothesis of a season of birth bias in BN. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:690–692)
Sunlight Photolysis of Decamethyltitanocene Dihydrosulfide Affords the Titanium Sulfide Cage Clusters (Cp*Ti)6S8 and (Cp*Ti)4S6
Authors: Gyepes Róbert , Císařová Ivana , Pinkas Jiří , Kubišta Jiří , Horáček Michal , Mach Karel 
Published: June 2013

AbstractSunlight photolysis of decamethyltitanocene dihydrosulfide [Cp*2Ti(SH)2] (1, Cp* = η5‐C5Me5) in toluene affords the titanium sulfide clusters [(Cp*Ti)6(μ3‐S)8] (4) and [(Cp*Ti)4(μ3‐S)3(μ2‐S)3] (5), the former in very low yield and the latter in good yield. The crystal structures of both compounds are toluene solvates and are based on a nearly regular titanium octahedron for 4 and a trigonal pyramid for 5. The [(Cp*Ti)3(μ3‐S)(μ2‐S)3] (6) complex isolated in a trace amount from the photolysis of 1 in hexane could be a precursor of 4. A plausible mechanism for the formation of 5 and 6 follows a mechanism recently proposed for photolysis of [Cp*2Ti(OH)2] by U. Rosenthal et al.
Conditional spectrum‐based ground motion selection. Part I: Hazard consistency for risk‐based assessments
Authors: Lin Ting , Haselton Curt B. , Baker Jack W. 
Published: June 2013

SUMMARYThe conditional spectrum (CS, with mean and variability) is a target response spectrum that links nonlinear dynamic analysis back to probabilistic seismic hazard analysis for ground motion selection. The CS is computed on the basis of a specified conditioning period, whereas structures under consideration may be sensitive to response spectral amplitudes at multiple periods of excitation. Questions remain regarding the appropriate choice of conditioning period when utilizing the CS as the target spectrum. This paper focuses on risk‐based assessments, which estimate the annual rate of exceeding a specified structural response amplitude. Seismic hazard analysis, ground motion selection, and nonlinear dynamic analysis are performed, using the conditional spectra with varying conditioning periods, to assess the performance of a 20‐story reinforced concrete frame structure. It is shown here that risk‐based assessments are relatively insensitive to the choice of conditioning period when the ground motions are carefully selected to ensure hazard consistency. This observed insensitivity to the conditioning period comes from the fact that, when CS‐based ground motion selection is used, the distributions of response spectra of the selected ground motions are consistent with the site ground motion hazard curves at all relevant periods; this consistency with the site hazard curves is independent of the conditioning period. The importance of an exact CS (which incorporates multiple causal earthquakes and ground motion prediction models) to achieve the appropriate spectral variability at periods away from the conditioning period is also highlighted. The findings of this paper are expected theoretically but have not been empirically demonstrated previously. Copyright © 2013 John Wiley & Sons, Ltd.