bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usability Testing Situs Daring Sebagai Evaluasi User Experience (Studi Kasus Situs PERUMDAM Among Tirto)
Authors: Soetam Rizky Wicaksono  , Vennina Githa Ananta  
Published: August 2024

Tampilan dalam sebuah situs daring tidak hanya menjadi antar muka pertama yang dilihat oleh pengguna, terutama dari segi kemudahan akses serta familiaritas dari interaksi dalam situs tersebut. Kemudahan tersebut menjadi relatif pada saat pengguna situs sebuah perusahaan berinteraksi, sehingga desainer serta pengembang situs harus menyerap aspirasi dari pengguna tanpa harus meninggalkan fungsionalitas, ehingga situs yang telah dalam tahapan daring dan dipublikasikan ke pihak pelanggan perlu menjalani evaluasi demi terciptanya kepuasan pelanggan. Evaluasi untuk keperluan tersebut dapat dilakukan dengan menggunakan usability testing yang dapat menghasilkan saran dan pertimbangan agar situs dapat lebih fokus kepada pelanggan dan mampu berjalan secara efisien, efektif dan memuaskan dalam konteks penggunaannya. Hal tersebut juga menjadi perhatian bagi pengelola situs di PERUMDAM Among Tirto Kota Batu yang membutuhkan adanya evaluasi situs untuk pengembangan versi berikutnya. Evaluasi usability testing dilakukan dengan menggunakan metode FGD (Focus Group Discussion) sesuai dengan prinsip dari pelaksanaan teknik think aloud dalam usability testing. serta prinsip discounted usability testing. Responden diberikan delapan aspek pertanyaan yang didalamnya meliputi aspek usability Nielsen yaitu: learnability, efficiency, memorability, errors dan satisfaction. Berdasarkan hasil dari evaluasi usability testing yang telah dilakukan, maka didapatkan bahwa secara umum masih belum memenuhi unsur learnability yang baik, unsur memorability juga wajib diperbaiki dengan menambahkan breadcrumb yang lebih jelas dan terlihat oleh pengguna. Hal lain yang mendapatkan nilai baik adalah unsur errors yang tidak terlihat dalam navigasi menu di dalam situs. Sedangkan dari unsur efficiency, masih kurang puas, dikarenakan banyaknya redundansi menu. Secara umum responden masih mengungkapkan unsur satisfaction namun wajib diredesain sesuai dengan saran yang telah mereka berikan.
Exploration of The Social Context of The Pandemic in The Andromeda Strain by Michael Crichton: A Recent Review
Authors: Ali Muhammad Ilham 
Published: August 2024

This study looks at how this novel depicts a society that is both fascinated by science and terrified. This study in the book "The Andromeda Strain" offers a perceptive viewpoint on pandemics and their social repercussions. This research analyzes the social conditions and circumstances during the pandemic in The Andromeda Strain. This research uses the descriptive qualitative method with the Mimetic and sociological approaches. Based on the research findings and analysis, the result shows the existence of social changes due to the pandemic in this novel. These changes are the actions all the characters involved in the book take. These actions include cases of mass death due to a bacterium called Andromeda and cases of suicide, but there are also prevention efforts such as lockdowns and quarantines or efforts tackling bacteria; research called the wildfire project was also held, and there was also cooperation in dealing with existing cases of andromeda bacteria.Keywords: Pandemic, Social Situation, The Andromeda Strain.
Exploring Entrepreneurial Intentions among Vocational High School Graduates: The Impact of Entrepreneurial Knowledge and Attitude
Authors: Maulida Fita Hanan , Noviani Leny , Sudarno Sudarno 
Published: August 2024

This research addresses the significant issue of unemployment among vocational school graduates in Indonesia and the low level of entrepreneurship among them. While previous studies have predominantly focused on the entrepreneurial intentions of high school and university student samples, there isthere needs to be more understanding of the entrepreneurial intentions of vocational school graduates. Bridging the gap, this study explores the determinants of entrepreneurial intentions among vocational school graduates, particularly examining the roles of entrepreneurial knowledge and attitude toward entrepreneurship. Additionally, this research explores attitude toward entrepreneurship as a mediating variable. The study employs a survey method with data from 305 vocational school graduates in Indonesia as participants. D ta analysis uses partial least squares structural equation modelling (PLS-SEM) with SmartPLS 4.0 software. The findings indicate that entrepreneurial Knowledge has a significant positive relationship with attitude toward entrepreneurship and entrepreneurial intention. Furthermore, this research finds that attitude toward entrepreneurship exhibits a complementary partial mediation effect between entrepreneurial Knowledge and entrepreneurial intention. The study also suggests that interest in entrepreneurship and professional experience can enhance the entrepreneurial intentions of vocational high school graduates. These insights offer valuable guidance for policymakers and educators in designing strategies to promote entrepreneurship among vocational school graduates, ultimately addressing unemployment challenges in Indonesia.
Pengaruh Motivasi dan Lingkungan Belajar Terhadap Prestasi Belajar Ilmu Pengetahuan Sosial
Authors: Maesaroh Imas , Kasyadi Soeparlan , Sumarto Sumaryati Tjitro 
Published: August 2024

<p>Tujuan dari penelitian ini adalah untuk mengetahui Pengaruh motivasi dan lingkungan belajar secara bersama-sama terhadap prestasi belajar IPS siswa SMP Negeri di Jakarta Selatan. Sampel yang digunakan 84 siswa sebagai sampel penelitian menggunakan teknik proposional random sampling dengan regresi linear berganda. Berdasarkan hasil hipotesis dan analisis data, disimpulkan sebagai berikut: 1). Terdapat pengaruh yang signifikan motivasi dan lingkungan belajar secara bersama-sama terhadap prestasi belajar IPS siswa SMP Negeri di Jakarta Selatan. Hal ini dibuktikan dengan nilai Sig = 0,000 &lt; 0,05 dan Fhitung = 23,531. 2). Terdapat pengaruh yang signifikan motivasi belajar terhadap prestasi belajar IPS siswa SMP Negeri di Jakarta Selatan. Hal ini dibuktikan dengan nilai Sig = 0,002 &lt; 0,05 dan thitung = 3,217. 3). Terdapat pengaruh yang signifikan lingkungan belajar terhadap prestasi belajar IPS siswa SMP Negeri di Jakarta Selatan. Hal ini dibuktikan dengan nilai Sig = 0,000 &lt; 0,05 dan thitung = 4,545. </p>
Pengaruh Model Discovery Learning Terhadap Kemampuan Berfikir Kreatif Mata Pelajaran PAI Kelas VIII di SMP Negeri 49 Bandung
Authors: Fauziah Siti Arofah , Suhendi Endi 
Published: August 2024

Penelitian ini berfokus pada masalah siswa yaitu siswa kurang mandiri saat proses pembelajaran dan hanya menunggu perintah guru, dan kurangnya pengetahuan bagaimana cara untuk kreatif dalam pembelajaran.tujuan dalam penelitian ini, yaitu 1) Untuk mengetahui Model Discovery learning di SMP Negeri 49 Bandung 2) Untuk mengetahui kemampuan berfikir kreatif siswa mata pelajaran PAI kelas VIII di SMP Negei 49 Bandung 3) Untuk mengetahui pengaruh Model Discovery learning terhadap kemampuan berfikir kreatif mata pelajaran PAI kelas VIII di SMP Negeri 49 Bandung. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan pendekatan kuantitatif. Teknik atau dalam pengambilan data yang di gunakan dalam penelitian ini adalah angket, observasi, dan dokumentasi. Dalam pengambilan samppelnya menggunakan random sampling. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis instrumen, uji asumsi klasik, uji statistik deskriptif dan pengujian hipotesis uji t, untuk mengetahui besarnya pengaruh varabel tanggapan siswa tentang discovery learning terhadap kemampuan berfikir kreatif, peneliti menggunakan analisis regresi linear sederhana. Hasil dalam penelitian ini yakni, hasil pengujian statistik deskriptif pada variabel (X) tanggapan siswa tentang model discovery learning mendapatkan hasil rata-rata sebesar (48,97) dengan di kategorikan cukup , hasil pengujian statistik deskriptif pada variabel (Y) kemampuan berfikir kreatif (49,43) di kategorikan cukup, Hasil dari pengujian statistik yang menggunakan SPSS 20 pada tanggapan siswa tentang model discovery learning terhadap kemampuan berfikir kreatif siswa diperoleh nilai t hitung nya = 2,025 < 2,048 = t tabel, dan sig. = 0,052 > 0,05 (5%) jadi Ho di terima, ini berarti tanggapan siswa tentang discovery learning tidak berpengaruh signifikan terhadap kemampuan berfikir kreatif, berdasarkan besarnya R square 88%, jadi 88% di pengaruhi oleh sebab-sebab lain bukan dipengaruhi oleh model discovery learning.
टाइपिस्ट कथामा लैङ्गिक सचेतना
Authors: बरई Barai त्रिभुवन Tribhuvan 
Published: August 2024

प्रस्तुत लेखमा लैङ्गिक समालोचनाको सैद्धान्तिक पर्याधारको केन्द्रीयतामा भवानी भिक्षुद्वारा लिखित ‘टाइपिस्ट’ कथाको मूल्याङ्कन गरिएको छ । ‘टाइपिस्ट’ कथामा लैङ्गिक सचेतनाका केकस्ता अभिलक्षणहरूको प्रयोग गरिएको छ भन्ने जिज्ञासाको परिपूर्ति गर्नाका निम्ति यो अध्ययन गरिएको हो । प्राथमिक एवम् द्वितीयक स्रोतका सामग्रीको उपयोग गरी लैङ्गिक समालोचनाको सैद्धान्तिक पर्याधारलाई आधार मानी गुणात्मक र पाठविश्लेषणात्मक शोधविधि अपनाई यस लेखलाई पूर्णता प्रदान गरिएको छ । समन्यायको अवधारणाको अभिव्यक्ति, लैङ्गिक प्रतिप्रभुत्वको प्रस्तुति तथा महिला र पुरुषको सहकार्यात्मक सम्बन्धमा जोड गरी तीनओटा सूचकका केन्द्रीयतामा प्रस्तुत कथाको मूल्याङ्कन यस अध्ययनमा गरिएको छ । यस लेखको अन्त्यमा मानव हुनुको गरिमालाई कलङ्कित तुल्याउने लैङ्गिक विभेद र उत्पीडनलाई किनाराकृत गरी इमानदारी र जवाफदेहिताका साथ पुरुषले महिलाको र महिलाले पुरुषको अस्तित्व र अस्मितालाई स्विकार्ने, एउटा पक्षले अर्को पक्षलाई हार्दिक प्रेम गर्ने, आपसी समन्वय र सहकार्यमा जीवन बिताउनेजस्ता कुराहरूलाई सर्वोपरि महङ्खव दिँदा समाजबाट लैङ्गिक विषमता हटी सामाजिक समानता कायम भई समतामूलक समाजको स्थापना हुने र त्यस कार्यले समग्र मानवजीवनमूल्य र मानवीय श्रेष्ठता कायम भई लोकमङ्गल हुने सचेतनासम्बन्धी विचारको सञ्चार यस कथामा गरिएको एवम् यस्तो जनहितकारी विचारधारालाई जीवन्त, कलात्मक र प्रभावान्वितिपूर्ण ढङ्गले पाठकसमक्ष पु¥याउने विशिष्ट सिर्जनात्मक सामथ्र्य कथाकार भवानी भिक्षुमा सशक्त रूपमा रहेको तथा साहित्यकारलाई लैङ्गिक समता र समविकासको केन्द्रीयतामा साहित्यिक कृतिको रचना, समालोचक र अध्येतालाई लैङ्गिक समालोचनाका आधारमा साहित्यिक कृतिको अध्ययन एवम् पाठकलाई लैङ्गिक समानता, सहकार्य र समन्यायको अवधारणाअनुसारको आचरण र व्यवहार अपनाई मानवजीवनको गरिमा, श्रेष्ठता र सार्थकता सिद्ध गर्ने कार्यमा सघाउने सार प्राप्त हुनुलाई निष्कर्षात्मक प्राप्तिका रूपमा प्रस्तुत गरिएको छ ।
A comparative ultrasound evaluation of two cases of prenatal and postnatal hydrocele
Authors: Afodun Adam Moyosore , Quadri Khadijah Kofoworola , Ayinde Taofeek Olanrewaju , Odumeru Emmanuel Adeyemi , Mukangendo Mecthilde , Okesina Akeem Ayodeji 
Published: August 2024

Background: Ultrasonography plays a major role in distinguishing extra-testicular and intratesticular abnormalities. A hydrocele of a male fetus characterised by a ‘half-moon’ hypoechoic fluid rim around the testis was observed. In adults, it is evidenced by serous fluid collection between the parietal and visceral layers of the tunica vaginalis.
Case presentation: A comparative analysis of two cases of in-vitro and in-vivo diagnosis of hydrocele in a woman at 30 weeks of gestation and a 38-year-old male was made. The crux of the report on the prenatal hydroceles’ variety showed constancy of unchanged fluid volume, suggesting it to be a non-communicating type. The report is contrary to a communicating variety that enlarges throughout gravidae with possible inguinal hernia. There are few comparative hydrocele case sonograms in literature.
Conclusion: Ultrasound is a safe, reliable, and accurate method for evaluating patients with scrotal diseases, and the approach to dual sono-diagnosis is surgery when unresolved to eliminate spermatic cord compromise.
Inovasi Layanan Ritel Pangan Melalui Penciptaan Nilai Bersama: Kolaborasi Business-to-Business Kelompok Tani dan Ritel Online Berbasis Start-Up
Authors: Utami Hesty Nurul , Wiyono Sulistyodewi Nur 
Published: August 2024

Perkembangan teknologi informasi telah memungkinkan pelaku agribisnis untuk berinteraksi secara interaktif dengan konsumen sebagai upaya memahami dan memenuhi tuntutan kebutuhan konsumen yang semakin beragam. Penyediaan layanan sebagai kombinasi pemasaran produk pangan dapat dijadikan dasar kustomisasi penawaran dan penciptaan nilai bersama. Penelitian ini bertujuan untuk mengeksplorasi konsep penciptaan nilai bersama yang dilakukan melalui kolaborasi antar entitas bisnis (business-to-business – B2B) antara kelompok tani dengan peritel pangan online sebagai bentuk inovasi layanan ritel pangan. Penelitian ini menggunakan pendekatan induktif kualitatif menggunakan wawancara mendalam dengan pelaku usaha yang terlibat di jalur pemasaran ritel online pangan segar dan data diolah menggunakan analisis tematik. Hasil analisis menunjukkan bahwa petani dan pedagang besar melakukan transformasi kelembagaan pemasaran untuk melakukan penetrasi pasar baru untuk pasar online dengan membentuk lembaga kelompok tani dengan mengusung prinsip inklusif, kolaboratif, transparansi, pemberdayaan, edukasi, dan keadilan sosial. Penciptaan nilai bersama merupakan bentuk kolaborasi yang dilakukan antara kelompok tani dengan ritel online dengan luaran berupa peningkatan wawasan pengelolaan bisnis pangan yang lebih professional, pemahaman penanggungan risiko dalam bisnis, pemanfaatan arus informasi yang lebih cepat, penetrasi dan portofolio pasar yang lebih menguntungkan, peningkatan pengetahuan dan kapabilitas petani, pemahaman kolaborasi bisnis yang lebih baik di era digital dan persaingan, serta terciptanya mental capital petani di dalam kelompok tani, serta upaya penawaran produk pangan yang lebih baik kepada konsumen. Penciptaan nilai bersama dapat menjadi konsep bisnis dan pemasaran yang digunakan pelaku usaha agribisnis sayuran untuk memperoleh keunggulan kompetitif yang berkeadilan bagi semua pihak yang terlibat di dalam jalur pemasaran ritel online pangan.
Використання бандури в сучасних мистецьких проєктах: відновлення традицій у сучасному світі
Authors: Buchkivska Galyna , Kachurynets Serhii , Tsyhaniuk Liutsiia 
Published: August 2024

У статті здійснено аналіз історичних та суспільно-політичних умов виникнення та розвитку бандурного мистецтва в Україні, охарактеризовано основні засади академізації бандурного виконавства, що розпочалося на початку ХХ століття і пов’язане з діяльністю видатного українського діяча, композитора, літератора, інженера, кобзаря та конструктора бандури Гната Хоткевича та його послідовників. Здійснено огляд процесу виведення бандурного мистецтва за межі автентичної кобзарської традиції, запровадження професіоналізації бандурного виконавства на різних рівнях освіти, удосконалення конструкції бандури, що здійснило значний вплив на зміну історико-суспільних функцій цього інструменту на зламі ХХ–ХХІ століть, аналізуються наслідки радянського втручання в розвиток бандурного мистецтва в Україні. У дослідженні розглянуто використання бандури в мистецьких проєктах у ХХІ столітті.
Presentation, surgical outcome, and supplementary motor area syndrome risk of posterior superior frontal gyrus tumors
Authors: Bauman Megan M. J. , Jusue-Torres Ignacio , White Jaclyn J. , Bouchal Samantha M. , Hsu Andrea R. , Ha Yooree , Pumford Andrew D. , Hong Sukwoo , Riviere-Cazaux Cecile , Wang Kimberly , Brown Desmond A. , Helal Ahmed , Parney Ian F. 
Published: August 2024

OBJECTIVE
Following resection of posterior superior frontal gyrus (PSFG) tumors, patients can experience supplementary motor area (SMA) syndrome consisting of contralateral hemiapraxia and/or speech apraxia. Given the heterogeneity of PSFG tumors, the authors sought to determine the risk of postoperative deficits and assess predictors of outcomes for all intraparenchymal PSFG tumors undergoing surgery (biopsy or resection), regardless of histology.

METHODS
This was a retrospective single-center cohort study of adult PSFG-region tumors undergoing biopsy or resection by a single surgeon.

RESULTS
A total of 106 consecutive patients undergoing 123 procedures (21 biopsies, 102 resections) fulfilled inclusion and exclusion criteria. Anaplastic astrocytomas were the most frequent among resected tumors (39% vs 29%), while glioblastomas were most common among biopsies (38% vs 27%) (p < 0.0001). The biopsy cohort was more likely to have tumor involvement outside the PSFG (90% vs 62%) (p = 0.011), most commonly in the motor cortex (67% vs 31%) (p = 0.005). Seizures were the most common presenting symptom in the resection cohort (p = 0.017), while motor deficits were more common in the biopsy cohort (58% vs 29%) (p < 0.001). Immediate postoperative neurological deficits occurred in 71 cases (58%), but only 3 of the deficits were permanent at 6 months of follow-up (2%). Postoperative SMA syndrome occurred in 48 cases (47%) and was significantly associated with involvement of the motor cortex (p = 0.018) or cingulate gyrus (p = 0.023), which were also significant in multivariate analysis as risk factors for SMA syndrome. However, postoperative SMA syndrome was not significantly associated with overall survival (p = 0.51). There were no perioperative deaths, but corpus callosum involvement (p < 0.001), contrast enhancement (p = 0.003), and glioblastoma pathology (p = 0.038) predicted worse overall survival in patients undergoing resection.

CONCLUSIONS
Nearly half of all patients undergoing resection of PSFG-region tumors experience a postoperative SMA syndrome. Individuals with corpus callosum and/or motor cortex involvement may be at an increased risk of experiencing SMA syndrome. However, these deficits are usually transient, and the risk of permanent new deficits is very low (3%). Preoperative characteristics including corpus callosum involvement and tumor enhancement—in addition to pathology—might serve as predictors of overall survival within this patient population.
Long-term survivors in 976 supratentorial glioblastoma, IDH-wildtype patients
Authors: Aboubakr Oumaima , Moiraghi Alessandro , Elia Angela , Tauziede-Espariat Arnault , Roux Alexandre , Leclerc Arthur , Planet Martin , Bedioui Aziz , Simboli Giorgia Antonia , Dhermain Frédéric , Parraga Eduardo , Benevello Chiara , Fathallah Houssem , Muto Jun , Chrétien Fabrice , Dezamis Edouard , Oppenheim Catherine , Varlet Pascale , Zanello Marc , Pallud Johan 
Published: August 2024

OBJECTIVE
Glioblastoma, isocitrate dehydrogenase (IDH)–wildtype is the most aggressive glioma with poor outcomes. The authors explored survival rates and factors associated with long-term survival in patients harboring a glioblastoma, IDH-wildtype.

METHODS
In an observational, retrospective, single-center study, the authors examined the medical records of 976 adults newly diagnosed with supratentorial glioblastomas, IDH-wildtype between January 2000 and January 2021. They analyzed clinical-, imaging-, and treatment-related factors associated with 2-year and 5-year survival.

RESULTS
The median overall survival was 11.2 months (12.2 months for patients included after 2005 and the introduction of standard combined chemoradiotherapy). The median progression-free survival was 9.4 months (10.0 months for patients included after 2005). Overall, 17.6% of patients reached a 2-year overall survival, while 2.2% of patients reached a 5-year overall survival. Furthermore, 6.6% of patients survived 2 years without progression, while 1.1% of patients survived 5 years without progression. Two factors that were consistently associated with 2-year and 5-year survival were first-line oncological treatment with standard combined chemoradiotherapy and methylated O6-methylguanine-DNA methyltransferase promoter. Other factors that were significantly associated with 2-year or 5-year survival were age at diagnosis ≤ 60 years, headaches or signs of raised intracranial pressure at diagnosis, cortical contact of contrast enhancement, no contrast enhancement crossing the midline on initial imaging, total or subtotal tumor resection, and a second line of oncological treatment at recurrence. Within 21 cases of 5-year survival, 18 were confirmed to be glioblastomas, IDH-wildtype, and 7 of the 5-year survivors (38.9%) had additional genetic alterations: 3 cases had an FGFR mutation or fusion, 3 cases had a PIK3CA mutation, 1 case had a PTPN11 mutation, and 1 case had a PMS2 mutation in the context of constitutional mismatch repair deficiency syndrome.

CONCLUSIONS
Five-year overall survival in patients with glioblastoma, IDH-wildtype is extremely low. Predictors of a longer survival are mostly treatment factors, emphasizing the importance of a complete oncological treatment plan, when achievable. Glioblastoma, IDH-wildtype 5-year survivors could be screened for actionable targets in case of recurrence.
Clinicogenomic predictors of survival and intracranial progression after stereotactic radiosurgery for colorectal cancer brain metastases
Authors: Gui Chengcheng , Walch Henry S. , Mueller Kirin D. , Boe Lillian A. , Ilica A. Turan , Strong James , Eichholz Jordan E. , Yu Kenny K. H. , Wilcox Jessica A. , Manca Paolo , Yu Yao , Yamada Yoshiya , Imber Brandon S. , Maron Steven B. , Foote Michael B. , Yaeger Rona , Schultz Nikolaus , Pike Luke R. G. 
Published: August 2024

OBJECTIVE
Brain metastases (BM) from colorectal cancer (CRC) are associated with dismal prognosis. When BM-directed therapy is considered, better methods are needed to identify patients at risk of poor oncological outcomes in order to optimize patient selection for closer surveillance or escalated therapy. The authors sought to identify clinicogenomic predictors of survival and intracranial disease progression after CRC BM have been treated with stereotactic radiosurgery (SRS).

METHODS
Patients with newly diagnosed CRC BM treated with SRS between 2009 and 2022 who had next-generation genomic sequencing data available were included. Frameless SRS was delivered in 1–5 fractions, alone or after neurosurgical resection. Outcomes included overall survival (OS) and intracranial progression (IP), evaluated per patient treated with SRS, and local progression (LP), evaluated per BM. Associations between baseline clinicogenomic features and outcomes were evaluated with Cox regression and competing risk regression, with death as a competing risk.

RESULTS
This analysis included 123 patients with 299 BM. At BM diagnosis, 111 patients (90%) had progressive extracranial disease, and 79 patients (64%) had ≥ 3 sites of extracranial metastasis. The median (IQR) number of BM was 2 (1–3) per patient. The median (IQR) biologically effective dose (BED) was 51.3 (51.3–65.1) Gy, corresponding to a prescription of 27 Gy in 3 fractions. OS, IP, and LP estimates at 1 year after SRS were 36%, 55%, and 12%, respectively. OS was independently associated with progressive extracranial disease (HR 4.26, 95% CI 1.63–11.2, p = 0.003) and ≥ 3 extracranial metastatic sites (HR 1.84, 95% CI 1.12–3.01, p = 0.02). LP was less likely when BM received BED ≥ 51.3 Gy (HR 0.24, 95% CI 0.07–0.78, p = 0.02), independent of BM diameter (HR 1.21/cm, 95% CI 0.8–1.84, p = 0.4). IP was independently associated with genomic alterations; TP53 driver alterations were associated with higher risk of IP (HR 2.71, 95% CI 1.26–5.79, p = 0.01), whereas MYC pathway alterations were associated with lower risk (HR 0.15, 95% CI 0.03–0.68, p = 0.01).

CONCLUSIONS
The authors identified clinicogenomic features associated with adverse outcomes after SRS for CRC BM. Progressive and extensive extracranial metastases predicted worse OS. Insufficient SRS doses predicted greater risk of LP. Wild-type TP53 and alterations in the MYC pathway were independently associated with lower risk of IP. Patients at high risk of IP may be considered for closer surveillance or escalated therapy.