bluuebunny/crossref_metadata_2025_split huggingface dataset:
The comparative cost-effectiveness of colorectal cancer screening using faecal immunochemical test vs. colonoscopy
Authors: Wong Martin CS , Ching Jessica YL , Chan Victor CW , Sung Joseph JY 
Published: September 2015

AbstractFaecal immunochemical tests (FITs) and colonoscopy are two common screening tools for colorectal cancer(CRC). Most cost-effectiveness studies focused on survival as the outcome and were based on modeling techniques instead of real world observational data. This study evaluated the cost-effectiveness of these two tests to detect colorectal neoplastic lesions based on data from a 5-year community screening service. The incremental cost-effectiveness ratio (ICER) was assessed based on the detection rates of neoplastic lesions and costs including screening compliance, polypectomy, colonoscopy complications and staging of CRC detected. A total of 5,863 patients received yearly FIT and 4,869 received colonoscopy. Compared with FIT, colonoscopy detected notably more adenomas (23.6% vs. 1.6%) and advanced lesions or cancer (4.2% vs. 1.2%). Using FIT as control, the ICER of screening colonoscopy in detecting adenoma, advanced adenoma, CRC and a composite endpoint of either advanced adenoma or stage I CRC was US$3,489, US$27,962, US$922,762 and US$23,981 respectively. The respective ICER was US$3,597, US$439,513, -US$2,765,876 and US$32,297 among lower-risk subjects; whilst the corresponding figure was US$3,153, US$14,852, US$184,162 and US$13,919 among higher-risk subjects. When compared to FIT, colonoscopy is considered cost-effective for screening adenoma, advanced neoplasia and a composite endpoint of advanced neoplasia or stage I CRC.
Highly Efficient Photocatalytic Hydrogen Production of Flower-like Cadmium Sulfide Decorated by Histidine
Authors: Wang Qizhao , Lian Juhong , Li Jiajia , Wang Rongfang , Huang Haohao , Su Bitao , Lei Ziqiang 
Published: September 2015

AbstractMorphology-controlled synthesis of CdS can significantly enhance the efficiency of its photocatalytic hydrogen production. In this study, a novel three-dimensional (3D) flower-like CdS is synthesized via a facile template-free hydrothermal process using Cd(NO3)2•4H2O and thiourea as precursors and L-Histidine as a chelating agent. The morphology, crystal phase and photoelectrochemical performance of the flower-like CdS and pure CdS nanocrystals are carefully investigated via various characterizations. Superior photocatalytic activity relative to that of pure CdS is observed on the flower-like CdS photocatalyst under visible light irradiation, which is nearly 13 times of pure CdS. On the basis of the results from SEM studies and our analysis, a growth mechanism of flower-like CdS is proposed by capturing the shape evolution. The imidazole ring of L-Histidine captures the Cd ions from the solution and prevents the growth of the CdS nanoparticles. Furthermore, the photocatalytic contrast experiments illustrate that the as-synthesized flower-like CdS with L-Histidine is more stable than CdS without L-Histidine in the hydrogen generation.
A novel recombinant slow-release TNF α-derived peptide effectively inhibits tumor growth and angiogensis
Authors: Ma Yi , Zhao Shaojun , Shen Shutao , Fang Shixiong , Ye Zulu , Shi Zhi , Hong An 
Published: September 2015

AbstractRMP16, a recombinant TNF α-derived polypeptide comprising a specific human serum albumin (HSA)-binding 7-mer peptide identified by phage display screening (WQRPSSW), a cleavage peptide for Factor Xa (IEGR) and a 20-amino acid bioactive peptide P16 (TNF α segment including amino acid residues 75–94), was prepared by gene-engineering technology. RMP16 showed prolonged half-life, 13.11 hours in mice (half-lives of P16 and TNF α are 5.77 and 29.0 minutes, respectively) and obviously higher receptor selectivity for TNFRI than TNF α. RMP16 had significant inhibition effects for multiple tumor cells, especially prostate cancer Du145 cells and human vascular endothelial cells but not for human mammary non-tumorigenic epithelial cells. RMP16 can more effectively induce apoptosis and inhibit proliferation for DU145 cells than P16 and TNF α via the caspase-dependent apoptosis pathway and G0/G1 cell cycle arrest. In nude mice with transplanted tumor of DU145 cells, RMP16 significantly induced apoptosis and necrosis of tumor tissues but causing less side effects and tumor inhibitory rate reached nearly 80%, furthermore, RMP16 can potently inhibit tumor angiogenesis and neovascularization. These findings suggest that RMP16 may represent a promising long-lasting antitumor therapeutic peptide with less TNF α-induced toxicity.
The nitric oxide synthase 3 G894T polymorphism associated with Alzheimer’s disease risk: a meta-analysis
Authors: Liu Shengyuan , Zeng Fangfang , Wang Changyi , Chen Zhongwei , Zhao Bin , Li Keshen 
Published: September 2015

AbstractThe association between the G894T polymorphism (Glu298Asp) of nitric oxide synthase 3 (NOS3) and risk of Alzheimer’s disease (AD) was explored by performing a meta-analysis of case-control studies. Bibliographical searches were conducted in the MEDLINE, EMBASE and China National Knowledge Infrastructure (CNKI) databases without any language limitations. Two investigators independently assessed abstracts for relevant studies and reviewed all eligible studies. We adopted regrouping in accordance with the most probably appropriate genetic model. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of this association. We performed a meta-analysis including 21 published articles with 23 case-control studies (5,670 cases and 5,046 controls). In the analyses, we found significant association between G894T polymorphism and AD risk under a complete overdominant model (GG + TT vs. GT) (OR = 1.18; 95%CI, 1.04–1.35; P = 0.010). When stratified by time of AD onset, we found the association between this polymorphism and AD susceptibility to be more substantial among late onset patients than among early onset patients (OR for late vs. early onset: 1.33 vs. 1.02, P interaction = 0.049). The meta-analysis showed that the polymorphism G894T of NOS3 was associated with risk of AD.
Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function
Authors: Jamali Somayeh , Klier Michael , Ames Samantha , Felipe Barros L. , McKenna Robert , Deitmer Joachim W. , Becker Holger M. 
Published: September 2015

AbstractThe most aggressive tumour cells, which often reside in hypoxic environments, rely on glycolysis for energy production. Thereby they release vast amounts of lactate and protons via monocarboxylate transporters (MCTs), which exacerbates extracellular acidification and supports the formation of a hostile environment. We have studied the mechanisms of regulated lactate transport in MCF-7 human breast cancer cells. Under hypoxia, expression of MCT1 and MCT4 remained unchanged, while expression of carbonic anhydrase IX (CAIX) was greatly enhanced. Our results show that CAIX augments MCT1 transport activity by a non-catalytic interaction. Mutation studies in Xenopus oocytes indicate that CAIX, via its intramolecular H+-shuttle His200, functions as a “proton-collecting/distributing antenna” to facilitate rapid lactate flux via MCT1. Knockdown of CAIX significantly reduced proliferation of cancer cells, suggesting that rapid efflux of lactate and H+, as enhanced by CAIX, contributes to cancer cell survival under hypoxic conditions.
Associations between antioxidant vitamins and the risk of invasive cervical cancer in Chinese women: A case-control study
Authors: Guo Liyuan , Zhu Hong , Lin Chengjun , Che Jianhua , Tian Xiujuan , Han Shiyu , Zhao Honghui , Zhu Yumei , Mao Dongwei 
Published: September 2015

AbstractPrevious studies on the associations between dietary antioxidant vitamins and the risk of cervical cancer remain inconsistent and little evidence is available for serum antioxidant vitamins, which provide more accurate measurements of these nutrients. We conducted a case-control study of 458 incident cases with invasive cervical cancer and 742 controls to assess the effects of diet or serum antioxidant vitamins. Higher serum antioxidant vitamins were associated with a lower risk of cervical cancer after adjusting for potential confounders. The odds ratios (ORs) for the highest (vs. lowest) quartile were 0.66 (95% confidence interval [CI] = 0.46–0.93; P = 0.024) for α-carotene, 0.63 (95% CI = 0.45–0.90; P = 0.006) for β-carotene, 0.53 (95% CI = 0.37–0.74; P < 0.001) for vitamin E and 0.48 (95% CI = 0.33–0.69; P < 0.001) for vitamin C. Dietary intakes of vitamins E and C were inversely associated with the risk of cervical cancer. Risk of cervical cancer from serum antioxidant vitamins was more evident in passive smokers than non-passive smokers. These findings indicated that antioxidant vitamins (mainly α-carotene, β-carotene and vitamins E and C) might be beneficial in reducing the risk of invasive cervical cancer in Chinese women, especially in passive smokers.
Dimeric interactions and complex formation using direct coevolutionary couplings
Authors: dos Santos Ricardo N. , Morcos Faruck , Jana Biman , Andricopulo Adriano D. , Onuchic José N. 
Published: September 2015

AbstractWe develop a procedure to characterize the association of protein structures into homodimers using coevolutionary couplings extracted from Direct Coupling Analysis (DCA) in combination with Structure Based Models (SBM). Identification of dimerization contacts using DCA is more challenging than intradomain contacts since direct couplings are mixed with monomeric contacts. Therefore a systematic way to extract dimerization signals has been elusive. We provide evidence that the prediction of homodimeric complexes is possible with high accuracy for all the cases we studied which have rich sequence information. For the most accurate conformations of the structurally diverse dimeric complexes studied the mean and interfacial RMSDs are 1.95Å and 1.44Å, respectively. This methodology is also able to identify distinct dimerization conformations as for the case of the family of response regulators, which dimerize upon activation. The identification of dimeric complexes can provide interesting molecular insights in the construction of large oligomeric complexes and be useful in the study of aggregation related diseases like Alzheimer’s or Parkinson’s.
Acoustic build-up in on-chip stimulated Brillouin scattering
Authors: Wolff C. , Steel M. J. , Eggleton B. J. , Poulton C. G. 
Published: September 2015

AbstractWe investigate the role of the spatial evolution of the acoustic field in stimulated Brillouin scattering processes in short high-gain structures. When the gain is strong enough that the gain length becomes comparable to the acoustic wave decay length of order 100 microns, standard approximations treating the acoustic field as a local response no longer apply. Treating the acoustic evolution more accurately, we find that the backward SBS gain of sub-millimetre long waveguides is significantly reduced from the value obtained by the conventional treatment because the acoustic mode requires several decay lengths to build up to its nominal value. In addition, the corresponding resonance line is broadened with the development of side bands. In contrast, we argue that intra-mode forward SBS is not expected to show these effects. Our results have implications for several recent proposals and experiments on high-gain stimulated Brillouin scattering in short semiconductor waveguides.
Interface-Free Area-Scalable Self-Powered Electroluminescent System Driven by Triboelectric Generator
Authors: Yan Wei Xiao , Kuang Shuang Yang , Yang Li Hua , Pan Caofeng , Zhu Guang , Wang Zhong Lin 
Published: September 2015

AbstractSelf-powered system that is interface-free is greatly desired for area-scalable application. Here we report a self-powered electroluminescent system that consists of a triboelectric generator (TEG) and a thin-film electroluminescent (TFEL) lamp. The TEG provides high-voltage alternating electric output, which fits in well with the needs of the TFEL lamp. Induced charges pumped onto the lamp by the TEG generate an electric field that is sufficient to excite luminescence without an electrical interface circuit. Through rational serial connection of multiple TFEL lamps, effective and area-scalable luminescence is realized. It is demonstrated that multiple types of TEGs are applicable to the self-powered system, indicating that the system can make use of diverse mechanical sources and thus has potentially broad applications in illumination, display, entertainment, indication, surveillance and many others.
Clinical characteristics of protracted bacterial bronchitis in Chinese infants
Authors: Wang Yuqing , Hao Chuangli , Chi FanFan , Yu Xingmei , Sun Huiquan , Huang Li , Wang Meijuan , Ji Wei , Yan Yongdong , Zhu Hong , Shao Xuejun 
Published: September 2015

AbstractProtracted bacterial bronchitis (PBB) is the common cause of chronic cough in children worldwide, but its etiology has not been fully recognized in China. We retrospectively investigated a total of 66 hospitalized infants under the age of three years with chronic wet cough enrolled in the Affiliated Children’s Hospital of Soochow University from October 2010 to March 2014. All patients underwent bronchoscopy and broncho-alveolar lavage (BAL) samples were processed for microbiological and cytological analysis. Of 66 patients with wet cough, 50 (75.8%) were diagnosed with PBB. In the PBB group, wet cough was accompanied by wheezing (90%). Airway malacia were identified in 22 cases (44%). The clinical manifestations of PBB with airway malacia did not differ from those without malacia. Haemophilus influenzae (47.4%) and Streptococcus pneumoniae (36.8%) were the most commonly identified pathogens. Furthermore, CD3+ and CD3+CD4+ cells were significantly lower in the PBB group (p < 0.01), while CD19+, CD16+CD56+ and CD23+ cells were elevated (p < 0.01) in the PBB group. Our study revealed PBB is an important cause of chronic wet cough in Chinese infants and that changes of lymphocyte subsets are observed in children with PBB. Airway malacia frequently co-existed with PBB, but did not exacerbate the disease.
Personality traits predict brain activation and connectivity when witnessing a violent conflict
Authors: Van den Stock Jan , Hortensius Ruud , Sinke Charlotte , Goebel Rainer , de Gelder Beatrice 
Published: September 2015

AbstractAs observers we excel in decoding the emotional signals telling us that a social interaction is turning violent. The neural substrate and its modulation by personality traits remain ill understood. We performed an fMRI experiment in which participants watched videos displaying a violent conflict between two people. Observers’ attention was directed to either the aggressor or the victim. Focusing on the aggressor (vs. focusing on the victim) activated the superior temporal sulcus (STS), extra-striate body area (EBA), occipital poles and centro-medial amygdala (CMA). Stronger instantaneous connectivity occurred between these and the EBA, insula and the red nucleus. When focusing on the victim, basolateral amygdala (BLA) activation was related to trait empathy and showed increased connectivity with the insula and red nucleus. STS activation was associated with trait aggression and increased connectivity with the hypothalamus. The findings reveal that focusing on the aggressor of a violent conflict triggers more activation in categorical (EBA) and emotion (CMA, STS) areas. This is associated with increased instantaneous connectivity among emotion areas (CMA-insula) and between categorical and emotion (EBA-STS) areas. When the focus is on the victim, personality traits (aggression/empathy) modulate activity in emotion areas (respectively STS and postcentral gyrus/ BLA), along with connectivity in the emotional diencephalon (hypothalamus) and early visual areas (occipital pole).
Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells
Authors: Jin Xiaodong , Li Feifei , Zheng Xiaogang , Liu Yan , Hirayama Ryoichi , Liu Xiongxiong , Li Ping , Zhao Ting , Dai Zhongying , Li Qiang 
Published: September 2015

AbstractHeavy ion beams have advantages over conventional radiation in radiotherapy due to their superb biological effectiveness and dose conformity. However, little information is currently available concerning the cellular and molecular basis for heavy ion radiation-induced autophagy. In this study, human glioblastoma SHG44 and cervical cancer HeLa cells were irradiated with carbon ions of different linear energy transfers (LETs) and X-rays. Our results revealed increased LC3-II and decreased p62 levels in SHG44 and HeLa cells post-irradiation, indicating marked induction of autophagy. The autophagic level of tumor cells after irradiation increased in a LET-dependent manner and was inversely correlated with the sensitivity to radiations of various qualities. Furthermore, we demonstrated that high-LET carbon ions stimulated the unfolded protein response (UPR) and mediated autophagy via the UPR-eIF2α-CHOP-Akt signaling axis. High-LET carbon ions more severely inhibited Akt-mTOR through UPR to effectively induce autophagy. Thus, the present data could serve as an important radiobiological basis to further understand the molecular mechanisms by which high-LET radiation induces cell death.
Association of Juvenile Salmon and Estuarine Fish with Intertidal Seagrass and Oyster Aquaculture Habitats in a Northeast Pacific Estuary
Authors: Dumbauld Brett R. , Hosack Geoffrey R. , Bosley Katelyn M. 
Published: September 2015

AbstractStructured estuarine habitats, such as salt marshes, seagrass beds, and oyster reefs, are recognized as critical nurseries for juvenile fish and crustaceans. Estuarine habitat usage by fish, including juvenile Pacific salmon Oncorhynchus spp., was characterized by sampling with a modified tow net in Willapa Bay, Washington, where 20% of the intertidal area is utilized for shellfish aquaculture and thus is difficult to sample with conventional gear. Our goal was to compare fish use of relatively undisturbed habitats (open mudflat, seagrass, and channel habitats) with the use of nearby oyster culture habitat. Although many species showed significant temporal and spatial trends within the estuary, only Shiner Perch Cymatogaster aggregata exhibited a significant association with habitat. Juveniles of three salmonid species exhibited few associations with the low intertidal habitats over which they were captured or in the prey types they consumed there. Chinook Salmon O. tshawytscha, likely hatchery‐released ocean‐type fish, were the most common salmonid captured, and they utilized low intertidal areas throughout the summer as their mean size increased from 85 to 100 mm FL. Diets consumed by these larger juvenile Chinook Salmon were not associated with benthic habitat but instead consisted primarily of (1) insects from nearby marsh or terrestrial habitats and (2) planktonic prey, like decapod larvae and tunicate larvaceans. Juvenile Coho Salmon O. kisutch and Chum Salmon O. keta were captured earlier (April and May) and fed on a slightly different suite of prey taxa, which were also primarily pelagic rather than associated with the intertidal benthos. Our findings suggest that in this relatively shallow coastal estuary, the role of benthic habitat is not closely linked to its value as a source of food for large juvenile salmon out‐migrants utilizing the low intertidal areas where aquaculture occurs.
Discovering hospital admission patterns using models learnt from electronic hospital records
Authors: Arandjelović Ognjen 
Published: September 2015

Abstract
Motivation: Electronic medical records, nowadays routinely collected in many developed countries, open a new avenue for medical knowledge acquisition. In this article, this vast amount of information is used to develop a novel model for hospital admission type prediction.
Results: I introduce a novel model for hospital admission-type prediction based on the representation of a patient’s medical history in the form of a binary history vector. This representation is motivated using empirical evidence from previous work and validated using a large data corpus of medical records from a local hospital. The proposed model allows exploration, visualization and patient-specific prognosis making in an intuitive and readily understood manner. Its power is demonstrated using a large, real-world data corpus collected by a local hospital on which it is shown to outperform previous state-of-the-art in the literature, achieving over 82% accuracy in the prediction of the first future diagnosis. The model was vastly superior for long-term prognosis as well, outperforming previous work in 82% of the cases, while producing comparable performance in the remaining 18% of the cases.
Availability and implementation: Full Matlab source code is freely available for download at: http://ognjen-arandjelovic.t15.org/data/dprog.zip.
Contact: ognjen.arandjelovic@gmail.com
Potential growth of pelagic juvenile cod in relation to the 1978–2006 winter–spring zooplankton on the Northeast US continental shelf
Authors: Lough R. G. , Kristiansen T. 
Published: September 2015

Abstract
Environmental conditions during the pelagic juvenile cod period determine their fitness to survive settlement as demersal juveniles (0-group) and recruitment. This study examines the potential growth of pelagic juvenile cod in five areas of the New England Shelf based on time series of zooplankton and ocean temperature from surveys. An individual-based model was used to estimate the temporal variation in growth of juvenile cod at each survey station based on available prey of appropriate sized copepods of Calanus finmarchicus, Pseudocalanus spp., Centropages typicus, and Centropages hamatus. Mean juvenile cod growth was low (1–7% d−1) during January–February and March–April time series across all areas, Gulf of Maine (GOM), Eastern Georges Bank, Western Georges Bank, southern New England to Middle Atlantic Bight (MAB). Growth increased significantly in May–June with the seasonal increase in copepod density and temperature generally from South to North. The 1990–1999 warm years had the highest growth of 12–14% d−1 compared with the cooler 2000–2006 years and colder 1978–1989 years of similarly lower growth of 8–11% d−1. Growth in the MAB stayed the same 13% d−1 as in 1990–1999, whereas GOM growth decreased significantly to ∼6% d−1. High prey densities during May–June 1990–1999 for Georges Bank and GOM, followed by a strong decrease in 2000–2006 may explain the decrease in growth during the same periods. While all four copepod species contributed to potential growth, C. typicus, a more southern species, could be the more important prey for juveniles in the coastal areas during all months in contrast to Pseudocalanus spp. for the larvae. Centropages typicus also is the most adaptable and likely species able to expand and thrive under warmer climatic conditions, which could be of significance to future recruitment. Age-1 recruitment for Georges Bank cod was found to be related to juvenile growth.