bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health policy in South Australia 2003–10: primary health care workforce perceptions of the impact of policy change on health promotion
Authors: Jolley Gwyn , Freeman Toby , Baum Fran , Hurley Catherine , Lawless Angela , Bentley Michael , Labonté Ronald , Sanders David 
Published: August 2014

Issue addressedThis paper examines recent Australian health reform policies and considers how the primary health care (PHC) workforce experiences subsequent change and perceives its impact on health promotion practice.MethodsHealth policy documents were analysed to determine their intended impact on health promotion. Interviews were conducted with 39 respondents from four State‐funded PHC services to gain their perceptions of the impact of policy change on health promotion.ResultsThere have been a plethora of policy and strategy documents over the last decade relevant to PHC, and these suggest an intention to strengthen health promotion. However, respondents report that changes to the role and focus of PHC services have led to fewer opportunities for health promotion. Services are struggling to engage in health promotion activity, while funding and policy directions are prioritised to targeted, individual behaviour change.ConclusionThe experience of PHC workforce respondents in South Australia suggests that, despite policy intentions, health promotion practice is much reduced. Our research suggests that rigorous evaluation of health sector reforms should be undertaken to assess both intended and unintended outcomes in terms of service quality and delivery.So what?Health promoters are experiencing a contradictory policy and practice environment, and this research should assist health promoters in advocating for more government accountability in the implementation of policies in order to advance comprehensive PHC.?
Individual-level analysis of differential expression of genes and pathways for personalized medicine
Authors: Wang Hongwei , Sun Qiang , Zhao Wenyuan , Qi Lishuang , Gu Yunyan , Li Pengfei , Zhang Mengmeng , Li Yang , Liu Shu-Lin , Guo Zheng 
Published: August 2014

AbstractMotivation: The differential expression analysis focusing on inter-group comparison can capture only differentially expressed genes (DE genes) at the population level, which may mask the heterogeneity of differential expression in individuals. Thus, to provide patient-specific information for personalized medicine, it is necessary to conduct differential expression analysis at the individual level.Results: We proposed a method to detect DE genes in individual disease samples by using the disrupted ordering in individual disease samples. In both simulated data and real paired cancer-normal sample data, this method showed excellent performance. It was found to be insensitive to experimental batch effects and data normalization. The landscape of stable gene pairs in a particular type of normal tissue could be predetermined using previously accumulated data, based on which dysregulated genes and pathways for any disease sample can be readily detected. The usefulness of the RankComp method in clinical settings was exemplified by the identification and application of prognostic markers for lung cancer.Availability and Implementation: RankComp is implemented in R script that is freely available from Supplementary Materials.Contact: guoz@ems.hrbmu.edu.cn or slliu@ucalgary.caSupplementary information: Supplementary data are available at Bioinformatics online.
MR_predictor: a simulation engine for Mendelian Randomization studies
Authors: Voight Benjamin F. 
Published: August 2014

Abstract
Summary: I present MR_predictor, a simulation engine designed to guide the development and interpretation of statistical tests of causality between phenotypes using genetic instruments. MR_predictor provides a framework to model either individual traits or complex scenarios where multiple phenotypes are correlated or dependent on each other. Crucially, MR_predictor can incorporate the effects of multiple biallelic loci (linked or unlinked) contributing genotypic variability to one or more simulated phenotypes. The software has a range of options for sample generation, and output files generated by MR_predictor port into commonly used analysis tools (e.g. PLINK, R), facilitating analyses germane for Mendelian Randomization studies. Benchmarks for speed and power calculations for summary statistic-based Mendelian Randomization analyses are presented and compared with analytical expectation.
Availability and implementation: The simulation engine is implemented in PERL, and the associated scripts can be downloaded from github.com, and online documentation, tutorial and example datasets are available at http://coruscant.itmat.upenn.edu/mr_predictor.
Contact: bvoight@upenn.edu
Supplementary information: Supplementary derivations are available at Bioinformatics online.
MIRPIPE: quantification of microRNAs in niche model organisms
Authors: Kuenne Carsten , Preussner Jens , Herzog Mario , Braun Thomas , Looso Mario 
Published: August 2014

Abstract
Summary: MicroRNAs (miRNAs) represent an important class of small non-coding RNAs regulating gene expression in eukaryotes. Present algorithms typically rely on genomic data to identify miRNAs and require extensive installation procedures. Niche model organisms lacking genomic sequences cannot be analyzed by such tools. Here we introduce the MIRPIPE application enabling rapid and simple browser-based miRNA homology detection and quantification. MIRPIPE features automatic trimming of raw RNA-Seq reads originating from various sequencing instruments, processing of isomiRs and quantification of detected miRNAs versus public- or user-uploaded reference databases.
Availability and implementation: The Web service is freely available at http://bioinformatics.mpi-bn.mpg.de. MIRPIPE was implemented in Perl and integrated into Galaxy. An offline version for local execution is also available from our Web site.
Contact: Mario.Looso@mpi-bn.mpg.de
Supplementary information: Supplementary data are available at Bioinformatics online.
Severe Outbreak of the Emerging Soybean Viruses in Korea: An Increasing Threat
Authors: Seo Jang-Kyun , Park Ja-Yeon , Kwak Hae-Ryun , Kim Mi-Kyeong , Nam Moon , Lee Su-Heon , Kim Jeong-Soo , Choi Hong-Soo 
Published: August 2014

To determine the current incidence of Soybean yellow mottle mosaic virus (SYMMV), Soybean yellow common mosaic virus (SYCMV), and Soybean mosaic virus (SMV) in Korea, a nationwide survey was performed in 2013. A total of 417 soybean samples with typical virus symptoms were collected from 9 large-scale soybean-cultivated areas. To identify viruses from the collected samples, RT-PCR was performed using specific primers for SMV, SYMMV, or SYCMV. To confirm the RT-PCR results, PCR products were purified and sequenced. 22 July 2014. 18 August 2014.
New challenges in beamline instrumentation for the ESRF Upgrade Programme Phase II
Authors: Susini Jean , Barrett Raymond , Chavanne Joel , Fajardo Pablo , Götz Andy , Revol Jean-Luc , Zhang Lin 
Published: August 2014

Although beamline instrumentation is by nature driven by science, some recent examples serve as reminders that new technologies also enable new science. Indeed, exploiting the full scientific potential of forthcoming new storage rings with unprecedented source characteristics will, in many cases, require the development and implementation of novel instrumentation. In comparison with present synchrotron radiation facilities, the majority of beamlines should reap immediate performance benefits from the improved source emittance, principally through increased flux and/or horizontal beam size reduction at the sample. Instrumentation will have to develop along similar quantitative and qualitative trends. More speculative and more challenging is anticipating instrumentation that will be required by the new science made possible thanks to the unique coherence properties of diffraction-limited storage rings (DLSRs). ESRF has recently carried out a detailed feasibility study for a new ultra-low-emittance 6 GeV hybrid multibend storage ring, identified as ESRF Upgrade Programme Phase II. Although its performance is not expected to be equivalent to a DLSR source, the successful implementation of the ESRF Phase II project has to address scientific instrumentation issues that are also common to DLSRs. This article aims at providing a comprehensive review of some of the challenges encountered by the ESRF, in the context of the preparation of Phase II of its upgrade programme.
Alcohol related brain damage – a case of neglect?
Authors: Place Charlie 
Published: August 2014

Purpose
– The purpose of this paper is to argue that alcohol-related brain damage (ARBD) is a neglected problem. ARBD is a term that has begun to be used over the past decade to describe prolonged cognitive impairment caused by alcohol use, including Wernicke's encephalopathy and Korsakoff syndrome, alcohol dementia and alcohol-related brain injury.

Design/methodology/approach
– The paper provides an overview of ARBD describing the research around its prevalence and prognosis. There is a consensus in the literature that there is little research and a lack of awareness of this condition. The author uses case studies from his own experience working with people with ARBD to describe the difficulties in accessing appropriate assessment and care for this group, and suggests that they are often excluded in a way that is familiar from the experience of the person with “dual diagnosis”.

Findings
– Recommendations are made including raising awareness, improving screening for cognitive impairment and developing specialist services.

Originality/value
– ARBD appears to have been neglected in the “dual diagnosis” world and this paper attempts to address this, and so should be of interest to a wide range of professionals working with substance use, mental health, homelessness and social work.
Exploring coping strategies of carers looking after people with intellectual disabilities and dementia
Authors: D. Perera Bhathika , J. Standen Penny 
Published: August 2014

Purpose
– Carers play a vital role in looking after people with intellectual disabilities (ID). Caring role can be stressful and challenging in nature. Carers use various coping strategies to deal with stressors. The purpose of this paper is to explore coping strategies of carers looking after people with ID and dementia.

Design/methodology/approach
– Qualitative methodology was used to explore coping strategies. Focus groups and face-to-face interviews were carried out. These interviews were transcribed and analysed using thematic analysis.

Findings
– Nine interviews with carers (six paid carers and three family carers) and two focus groups with nursing staff looking after people with ID were carried out. Three key themes of “Narrative”, “Strategy toolbox” and “Compartmentalisation” emerged from analysis. Narrative and strategy took box were further subthemed. Carers had narratives about them and the person they look after. These “narratives” helped them to deal with day to day stressors. They also carried a “strategy toolbox”, which they used when they were in stressful situations. Compartmentalisation helped them to separate their personal life from work life as a carer.

Originality/value
– Understanding carers’ coping strategies is important when planning services to help carers who play an important role in our society. Professionals can support carers to understand and improve their existing coping skills and help them to thrive in their role as carers.
Prader-Willi syndrome and hyperphagia: an update
Authors: Stanley K. 
Published: August 2014

Purpose
– Prader-Willi syndrome (PWS) is a genetic disorder characterised by excessive appetite and progressive obesity. The causes of hyperphagia are unknown and this has implications on treatment limiting the options available. The purpose of this paper is to systematically synthesise the latest evidence regarding all causes as well as management of hyperphagia in people with PWS.

Design/methodology/approach
– A computer-based literature search, citation tracking and related articles search was undertaken. Primary research studies using genetically confirmed Prader-Willi participants specifically focused on the causes and treatment of overeating was included. Studies were described, critically analysed, presented and discussed in the review.

Findings
– In total, 18 relevant studies were identified. Nine studies were included in the causes of hyperphagia and focused largely on the roles of secretory hormones, and reward-related areas of the brain. Nine studies were included in the management of hyperphagia and related to physical exercise and food control, antidiabetic agents and weight loss surgery.

Originality/value
– The causes and the management of hyperphagia are still to be determined despite promising findings. The small number and heterogeneity of the included studies and participants limits conclusions. There is the need for future research to use larger systematic studies to validate findings so far.
Adapting to trauma: disengagement as a holding strategy
Authors: Barton David , Ward Kath , Roddam Hazel 
Published: August 2014

Purpose
– The purpose of this paper is to draw upon a range of material to improve the understanding of disengagement with everyday life, by some individuals who have learning disabilities and mental health difficulties. Illustrative incidents from historical clinical cases are utilised, to consider whether this reframing may enhance the interpretation of presenting behaviours.

Design/methodology/approach
– Key recurring themes within transpersonal literature were reviewed, relevant to adults with behaviour indicating a degree of disengagement from everyday life. These were grouped into Physical Realm, Psychosocial Realm and Realm of Being. Illustrative examples of behaviour are reviewed and re-interpreted within this framework.

Findings
– These examples generated plausible interpretations for the presenting behaviours within this framework of the Three Realms. These interpretations support a fresh understanding of the quality of the individual's inner experience. This paper suggests a potential framework to consider the way in which some individuals may experience a different quality of consciousness than the usual.

Practical implications
– Use of the Three Realms for behaviour interpretation should result into a more empathetic and client-centred approach that could reduce the need for aversive approaches, lessening risk for the client and any employing organisation. The identification of behaviours that signal participation in the Realm of Being could be defined and evaluated with the potential to be used to inform the nature and content of the support provided.

Originality/value
– This paper, rooted in clinical examples, offers an original synthesis with reasons to include the immaterial realm in the perspective of the human condition. This could benefit people with substantial episodes of disconnection from the Physical Realm and everyday culture and those who support them.
Current U.S. trends in formal performance appraisal: practices and opportunities – Part One
Authors: O. Longenecker Clinton , S. Fink Laurence , Caldwell Sheri 
Published: August 2014

Purpose
– The purpose of this two-part paper is to explore the current practices being employed in the formal performance appraisal process in a cross-section of US service and manufacturing organizations. In this paper, the authors identify the current trends that emerged from this research study and the improvement opportunities that exist for organizations that currently engage in the practice of formally appraising their personnel.

Design/methodology/approach
– The formal performance appraisal process, procedure, and rating form from 183 US organizations were reviewed by a three-person review panel and were content analyzed to identify current trends and opportunities for improvement.

Findings
– This qualitative analysis revealed that the average rating procedure had been in place for 5.5 years, to serve a wide variety of purposes, identified critical gaps in training, made it clear that organizations employ a wide variety of performance criteria in assessing their people.

Research limitations/implications
– The biggest limitation of this research is the fact that a convenience sample of 183 organizations was employed as the basis for this study.

Practical implications
– Data on the actual formal performance appraisal process of organizations are rather limited and this research provides critical insight into current practice limiting potential generalizability.

Social implications
– The social implications of this research suggests that organizations can do a much better job of equipping their leaders/employees to more effectively reap the organizational benefits of this key practice.

Originality/value
– Research in this area is not prevalent so this is a descriptive research study that both researchers and organizations can use to further their knowledge in formal performance appraisals.
Design, fabrication and test of an embedded lightweight kinematic autopilot (ELKA)
Authors: Petricca Luca , Hrishikeshavan Vikram , Ohlckers Per , Chopra Inderjit 
Published: August 2014

Purpose
– Unmanned vehicles flight is controlled by embedded circuits in the aircraft, under the remote control of a pilot on the ground. This circuit, called autopilot, represents one of the key elements inside the vehicles. The authors developed one of the smallest autopilot, specifically designed for low-weight low-power applications. The paper aims to discuss these issues.

Design/methodology/approach
– The system is based on STM32 ARM Cortex M3 microcontroller. It includes an onboard 9 DOF IMU (MPU9150) and a 2.4 GHz wireless transceiver (nRF24L01+).

Findings
– The embedded lightweight kinematic autopilot (ELKA) can pilot up to eight servomotors, and can be used to monitor more than 100 sensors. The final assembled board is 28×21 mm2 and weighs around 1.2 grams (battery excluded), and has successfully passed initial functionality tests.

Originality/value
– The authors presented the design, fabrication and initial tests of a lightweight kinematic autopilot (ELKA board version 1.0). The system has been designed in order to upgrade the state-of-art capability in sensing and processing over a previous autopilot (GINA), which is of similar weight and size. The small size (28×21 mm2) and the lightweight (around 1.2 grams) make ELKA one of the smallest autopilot in the world.
L1adaptive pitch control of an autonomous underwater vehicle
Authors: Sarhadi Pouria , Ranjbar Noei Abolfazl , Khosravi Alireza 
Published: August 2014

Purpose– The purpose of this paper is to show the application of an L1adaptive controller to control an autonomous underwater vehicle (AUV), considering realistic perturbations.Design/methodology/approach– In this paper, an L1adaptive controller is proposed to control the pitch channel of an AUV, for the first time. Based on a six degree of freedom (6-DOF) nonlinear equations, an appropriate linear model considering real perturbations is derived for the pitch channel of AUV. Then L1adaptive controller is applied on the model in the presence of the bounded disturbances and uncertainties. For this purpose, verified parameters of the REMUS AUV have been considered. Several simulations are performed in different operating conditions.Findings– The results confirm the quality of the proposed method in various situations. Furthermore, it is shown that the L1adaptive controller is potential to contribute in practical applications of AUVs such as other autonomous systems.Originality/value– This is the first time that this method has been applied to an AUV.
The acquisition puzzle and mispricing: evidence of over-optimism
Authors: Donnelly Ray , Hajbaba Amir 
Published: August 2014

Purpose– Researchers suspect that the overvaluation of equity issuing acquirers is a major cause of their subsequent post-event underperformance. Definitive conclusions regarding this overpricing hypothesis have not been possible since indicators of overpricing such as the book-to-market ratio and subsequent underperformance are open to alternative interpretations. The purpose of this paper is to corroborate or refute overvaluation as a driver of equity issuing acquirers’ subsequent underperformance.Design/methodology/approach– The literature has linked overvaluation of acquirers to over-optimistic expectations. The authors use analysts’ earnings forecasts to reflect the market's expectations. Over-optimism is indicated by subsequent earnings disappointments. The authors examine the relation between acquirers’ choice of payment method and their tendency to report disappointing earnings. The authors also examine the effect of including a more direct measure of over-optimism in a model to explain the long-run post-event buy-and-hold-abnormal returns of acquirers.Findings– The post-acquisition earnings of equity issuing acquirers disappoint more often than those of acquirers employing alternative financing methods. This relationship is confined to glamour acquirers. The ability of financing method to predict long-run post-acquisition performance is subsumed when direct measures of optimism are included in a model explaining long-run post-acquisition performance. This result is robust to controls for overpayment and other potential explanations of post-acquisition underperformance.Research limitations/implications– Acquirers’ management exploit their information advantage to exchange overvalued equity for the assets of the target company in accordance with Loughran and Ritter's (2000) behavioural timing hypothesis.Originality/value– The study provides new and unambiguous evidence that equity-issuing acquirers are optimistically priced at the time of acquisition.