bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion‐weighted MRI
Authors: Brown Anna M. , Nagala Sidhartha , McLean Mary A. , Lu Yonggang , Scoffings Daniel , Apte Aditya , Gonen Mithat , Stambuk Hilda E. , Shaha Ashok R. , Tuttle R. Michael , Deasy Joseph O. , Priest Andrew N. , Jani Piyush , Shukla‐Dave Amita , Griffiths John 
Published: May 2015

PurposeUltrasound‐guided fine needle aspirate cytology fails to diagnose many malignant thyroid nodules; consequently, patients may undergo diagnostic lobectomy. This study assessed whether textural analysis (TA) could noninvasively stratify thyroid nodules accurately using diffusion‐weighted MRI (DW‐MRI).MethodsThis multi‐institutional study examined 3T DW‐MRI images obtained with spin echo echo planar imaging sequences. The training data set included 26 patients from Cambridge, United Kingdom, and the test data set included 18 thyroid cancer patients from Memorial Sloan Kettering Cancer Center (New York, New York, USA). Apparent diffusion coefficients (ADCs) were compared over regions of interest (ROIs) defined on thyroid nodules. TA, linear discriminant analysis (LDA), and feature reduction were performed using the 21 MaZda‐generated texture parameters that best distinguished benign and malignant ROIs.ResultsTraining data set mean ADC values were significantly different for benign and malignant nodules (P = 0.02) with a sensitivity and specificity of 70% and 63%, respectively, and a receiver operator characteristic (ROC) area under the curve (AUC) of 0.73. The LDA model of the top 21 textural features correctly classified 89/94 DW‐MRI ROIs with 92% sensitivity, 96% specificity, and an AUC of 0.97. This algorithm correctly classified 16/18 (89%) patients in the independently obtained test set of thyroid DW‐MRI scans.ConclusionTA classifies thyroid nodules with high sensitivity and specificity on multi‐institutional DW‐MRI data sets. This method requires further validation in a larger prospective study. Magn Reson Med, 2015. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Magn Reson Med 75:1708–1716, 2016. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance.
Health professionals’ and patients’ perspectives on pelvic floor muscle training adherence—2011 ICS State‐of‐the‐Science Seminar research paper IV of IV
Authors: Frawley Helena C. , McClurg Doreen , Mahfooza Aishath , Hay‐Smith Jean , Dumoulin Chantale 
Published: May 2015

AbstractAimsThere is scant information on pelvic floor muscle training (PFMT) adherence barriers and facilitators. A web‐based survey was conducted (1) to investigate whether responses from health professionals and the public broadly reflected findings in the literature, (2) if responses differed between the two groups, and (3) to identify new research directions.MethodsHealth professional and public surveys were posted on the ICS website. PFMT adherence barriers and facilitators were divided into four categories: physical/condition, patient, therapy, and social‐economic. Responses were analyzed using descriptive statistics from quantitative data and thematic data analysis for qualitative data.ResultsFive hundred and fifteen health professionals and 51 public respondents participated. Both cohorts felt “patient‐related factors” constituted the most important adherence barrier, but differed in their rankings of short‐ and long‐term barriers. Health professionals rated “patient‐related” and the public “therapy‐related” factors as the most important adherence facilitator. Both ranked “perception of PFMT benefit” as the most important long‐term facilitator. Contrary to published findings, symptom severity was not ranked highly. Neither cohort felt the barriers nor facilitators differed according to PFM condition (urinary/faecal incontinence, pelvic organ prolapse, pelvic pain); however, a large number of health professionals felt differences existed across age, gender, and ethnicity. Half of respondents in both cohorts felt research barriers and facilitators differed from those in clinical practice.ConclusionsAn emphasis on “patient‐related” factors, ahead of “condition‐specific” and “therapy‐related,” affecting PFMT adherence barriers was evident. Health professionals need to be aware of the importance of long‐term patient perception of PFMT benefits and consider enabling strategies. Neurourol. Urodynam. 34:???–???, 2015. © 2015 Wiley Periodicals, Inc.
2014 consensus statement on improving pelvic floor muscle training adherence: International Continence Society 2011 State‐of‐the‐Science Seminar
Authors: Dumoulin Chantale , Hay‐Smith Jean , Frawley Helena , McClurg Doreen , Alewijnse Dianne , Bo Kari , Burgio Kathryn , Chen Shu‐Yueh , Chiarelli Pauline , Dean Sarah , Hagen Suzanne , Herbert Julia , Mahfooza Aishath , Mair Frances , Stark Diane , Van Kampen Marijke 
Published: May 2015

AimsTo summarize the findings and “expert‐panel” consensus of the State‐of‐the‐Science Seminar on pelvic floor muscle training (PFMT) adherence held prior to the 41st International Continence Society scientific meeting, Glasgow, 2011.MethodsSummaries of research and theory about PFMT adherence (based on a comprehensive literature search) were presented by subject experts at the 2011 Seminar to generate discussion and guidance for clinical practice and future research. Supplemental research, post‐seminar, resulted in, three review papers summarizing: (1) relevant behavioral theories, (2) adherence measurement, determinants and effectiveness of PFMT adherence interventions, and (3) patients' PFMT experiences. A fourth, reported findings from an online survey of health professionals and the public.ResultsFew high‐quality studies were found. Paper I summarizes 12 behavioral frameworks relevant to theoretical development of PFMT adherence interventions and strategies. Findings in Paper II suggest both PFMT self‐efficacy and intention‐to‐adhere predict PFMT adherence. Paper III identified six potential adherence modifiers worthy of further investigation. Paper IV found patient‐related factors were the biggest adherence barrier to PFMT adherence.ConclusionGiven the lack of high‐quality studies, the conclusions were informed by expert opinion. Adherence is central to short‐ and longer‐term PFMT effect. More attention and explicit reporting is needed regarding: (1) applying health behavior theory in PFMT program planning; (2) identifying adherence determinants; (3) developing and implementing interventions targeting known adherence determinants; (4) using patient‐centred approaches to evaluating adherence barriers and facilitators; (5) measuring adherence, including refining and testing instruments; and (6) testing the association between adherence and PFMT outcome. Neurourol. Urodynam. 34:???–???, 2015. © 2015 Wiley Periodicals, Inc.
Conjugated fluorescent polymer sensor for proteolytic activity detection with designed specificity
Authors: Komarova Elena , Bogomolova Anastasia , Aldissi Matt 
Published: May 2015

AbstractA portable fluorescence assay for direct endopeptidase activity detection has been developed with the use of a cyclophane‐based conductive conjugated fluorescent polymer and peptide substrates. The substrates, carrying internal quenching amino acid, were designed to be cleaved in a sequence‐specific manner by a protease of interest. Intact substrates were incapable of quenching the fluorescence of the polymer due to steric constraints. Upon specific cleavage, the quencher became exposed and could interact with the ring structure of the fluorescent polymer, disrupting the conjugation and quenching the fluorescence along the polymer chain. The approach was developed using a model Glu‐C endopeptidase from Staphylococcus aureus strain V8, detected in the picomolar to micromolar concentration range. The developed assay was tested for the detection of endopeptidase activity of botulinum toxin. The feasibility study showed that botulinum neurotoxin (BoNT)‐A could be detected down to picomolar concentration, with limit of detection of 5 pg, or 33 amol in 5 µL of sample, and a total assay time under 2 h. The assay exhibited high specificity and no cross‐reactivity with BoNT‐B was detected. Following this proof‐of‐concept work, the assay can be further optimized and expanded to differentiate between various botulinum toxin serotypes in their active proteolytic form, or modified for detection of proteases with other specificities. © 2015 Society of Chemical Industry
Scent properties by natural fragrance microencapsulation for footwear applications
Authors: Sánchez‐Navarro M Magdalena , Pérez‐Limiñana M Ángeles , Arán‐Ais Francisca , Orgilés‐Barceló César 
Published: May 2015

AbstractThe aim of this study was to develop footwear materials and footwear packaging with scent properties using microencapsulated fragrances from essential oils. For that purpose, gelatine–carboxymethylcellulose (CMC) and melamine–formaldehyde (MF) resin‐based microcapsules containing limonene were synthesised using complex coacervation and in situ polymerisation processes, respectively. The microcapsules were characterised using various experimental techniques and applied to footwear materials (leather and textile) as well as to paperboard as packaging material to evaluate their performance. The microcapsule durability under various conditions, such as rubbing and ironing, was analysed in order to simulate shoe manufacturing and shoe wearing conditions. The characterisation of the synthesised microcapsules showed two different delivery behaviours. On the one hand, MF microcapsules are more resistant so they may be incorporated into footwear materials that have to be exposed to high mechanical and thermal stresses, such as linings. On the other hand, gelatine–CMC microcapsules should be incorporated into footwear components, such as insoles, which are exposed to lower stresses because they are less resistant and might not resist the process conditions. The combination of both kinds of microcapsules could ensure a rapid as well as a long‐lasting fragrance release. © 2015 Society of Chemical Industry
Comparison of Measurement Systems for Sustainable Development at the National Level
Authors: Schoenaker Niels , Hoekstra Rutger , Smits Jan Pieter 
Published: May 2015

AbstractEconomic indicators, such as GDP, do not measure all dimensions of society's progress. Hundreds of alternative measurement systems have been proposed to measure sustainable development. This paper argues for harmonization of these methods, and facilitates this discussion by providing a detailed comparison of country‐level measures. The analysis includes 55 systems (12 composite indicators and 43 sustainable development indicator (SDI) sets). The analysis shows that SDI sets are more common than composite indicators. This paper also shows that composite indicators generally focus on environmental themes, while SDI sets are broader in scope through inclusion of more social themes. Overall, we find a great degree of agreement on the most popular indicators and themes in SDI sets. However, we do find that certain indicators are more prevalent in higher and lower income countries. The article emphasizes the need for harmonization of measurement systems, but also shows the importance of flexibility at the country level. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
Synovial Mesenchymal Stem Cells Promote Meniscus Regeneration Augmented by an Autologous Achilles Tendon Graft in a Rat Partial Meniscus Defect Model
Authors: Ozeki Nobutake , Muneta Takeshi , Matsuta Seiya , Koga Hideyuki , Nakagawa Yusuke , Mizuno Mitsuru , Tsuji Kunikazu , Mabuchi Yo , Akazawa Chihiro , Kobayashi Eiji , Saito Tomoyuki , Sekiya Ichiro 
Published: May 2015

Abstract
Although meniscus defects and degeneration are strongly correlated with the later development of osteoarthritis, the promise of regenerative medicine strategies is to prevent and/or delay the disease's progression. Meniscal reconstruction has been shown in animal models with tendon grafting and transplantation of mesenchymal stem cells (MSCs); however, these procedures have not shown the same efficacy in clinical studies. Here, our aim was to investigate the ability of tendon grafts pretreated with exogenous synovial-derived MSCs to prevent cartilage degeneration in a rat partial meniscus defect model. We removed the anterior half of the medial meniscus and grafted autologous Achilles tendons with or without a 10-minute pretreatment of the tendon with synovial MSCs. The meniscus and surrounding cartilage were evaluated at 2, 4, and 8 weeks (n = 5). Tendon grafts increased meniscus size irrespective of synovial MSCs. Histological scores for regenerated menisci were better in the tendon + MSC group than in the other two groups at 4 and 8 weeks. Both macroscopic and histological scores for articular cartilage were significantly better in the tendon + MSC group at 8 weeks. Implanted synovial MSCs survived around the grafted tendon and native meniscus integration site by cell tracking assays with luciferase+, LacZ+, DiI+, and/or GFP+ synovial MSCs and/or GFP+ tendons. Flow cytometric analysis showed that transplanted synovial MSCs retained their MSC properties at 7 days and host synovial tissue also contained cells with MSC characteristics. Synovial MSCs promoted meniscus regeneration augmented by autologous Achilles tendon grafts and prevented cartilage degeneration in rats. Stem Cells 2015;33:1927–1938
Berardinelli-Seip syndrome and achalasia: a shared pathomechanism?
Authors: van der Pol Rachel J. , Benninga Marc A. , Magré Jocelyne , Van Maldergem Lionel , Rotteveel Joost , van der Knaap Marjo S. , de Meij Tim G. 
Published: May 2015

Abstract
Berardinelli-Seip congenital lipodystrophy (BSCL) is an uncommon autosomal recessive disorder. Patients with BSCL present with a distinct phenotype since subcutaneous fat is largely lacking and musculature has become more prominent. During childhood, diabetes and acanthosis nigricans evolve and female patients may develop hirsutism. Different genes encoding this entity have been described. Achalasia is a rare esophageal motility disorder, characterized by its distinct motility pattern with absent or incomplete lower esophageal sphincter (LES) relaxations. The exact cause of achalasia is yet unknown. Here, we describe a patient with achalasia in the context of BSCL, which might be linked by a shared pathophysiologic background, as evaluated in this case report.
Conclusion: In a BSCL patient presenting with gastrointestinal symptoms, a motility disorder of the gastrointestinal tract should be considered.

What is Known:• Berardinelli-Seip congenital lipodystrophy (BSCL) and achalasia are both disorders characterized by low prevalence.

What is New:• Co-existence of both diseases is described in this report. Linkage by a potential common pathophysiologic background is discussed in this paper.
Functional role of oppA encoding an oligopeptide-binding protein from Lactobacillus salivarius Ren in bile tolerance
Authors: Wang Guohong , Li Dan , Ma Xiayin , An Haoran , Zhai Zhengyuan , Ren Fazheng , Hao Yanling 
Published: May 2015

Abstract
Lactobacillus salivarius is a member of the indigenous microbiota of the human gastrointestinal tract (GIT), and some L. salivarius strains are considered as probiotics. Bile tolerance is a crucial property for probiotic bacteria to survive the transit through the GIT and exert their beneficial effects. In this work, the functional role of oppA encoding an oligopeptide transporter substrate-binding protein from L. salivarius Ren in bile salt tolerance was investigated. In silico analysis revealed that the oppA gene encodes a 61.7-kDa cell surface-anchored hydrophilic protein with a canonical lipoprotein signal peptide. Homologous overexpression of OppA was shown to confer 20-fold higher tolerance to 0.5 % oxgall in L. salivarius Ren. Furthermore, the recombinant strain exhibited 1.8-fold and 3.6-fold higher survival when exposed to the sublethal concentration of sodium taurocholate and sodium taurodeoxycholate, respectively, while no significant change was observed when exposed to sodium glycocholate and sodium glycodeoxycholate (GDCA). Our results indicate that OppA confers specific resistance to taurine-conjugated bile salts in L. salivarius Ren. In addition, the OppA overexpression strain also showed significant increased resistance to heat and salt stresses, suggesting the protective role of OppA against multiple stresses in L. salivarius Ren.
Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy
Authors: Srivastava Gunjan , Matta Ajay , Fu Guodong , Somasundaram Raj Thani , Datti Alessandro , Walfish Paul G. , Ralhan Ranju 
Published: May 2015

Oral squamous cell carcinoma (OSCC) patients diagnosed in late stages have limited chemotherapeutic options, underscoring the great need for development of new anticancer agents for more effective disease management. We aimed to identify novel anticancer agents for OSCC using quantitative high throughput assays for screening six chemical libraries consisting of 5170 small molecule inhibitors. In depth characterization resulted in identification of pyrithione zinc (PYZ) as the most effective cytotoxic agent inhibiting cell proliferation and inducing apoptosis in OSCC cells in vitro. Further, treatment with PYZ reduced colony forming, migration and invasion potential of oral cancer cells in a dose‐dependent manner. PYZ treatment also led to altered expression of several key components of the major signaling pathways including PI3K/AKT/mTOR and WNT/β‐catenin in OSCC cells. In addition, treatment with PYZ also reduced expression of 14‐3‐3ζ, 14‐3‐3σ, cyclin D1, c‐Myc and pyruvate kinase M2 (PKM2), proteins identified in our earlier studies to be involved in development and progression of OSCCs. Importantly, PYZ treatment significantly reduced tumor xenograft volume in immunocompromised NOD/SCID/Crl mice without causing apparent toxicity to normal tissues. Taken together, we demonstrate in vitro and in vivo efficacy of PYZ in OSCC. In conclusion, we identified PYZ in HTS assays and demonstrated in vitro and in vivo pre‐clinical efficacy of PYZ as a novel anticancer therapeutic candidate in OSCC.
Otto Toeplitz's 1927 Paper on the Genetic Method in the Teaching of Mathematics
Authors: Fried Michael N. , Jahnke Hans Niels 
Published: May 2015

Argument“The problem of university courses on infinitesimal calculus and their demarcation from infinitesimal calculus in high schools” (1927) is the published version of an address Otto Toeplitz delivered at a meeting of the German Mathematical Society held in Düsseldorf in 1926. It contains the most detailed exposition of Toeplitz's ideas about mathematics education, particularly his thinking about the role of the history of mathematics in mathematics education, which he called the “genetic method” to teaching mathematics. The tensions and assumptions about mathematics, history of mathematics, and historiography revealed in this piece dedicated to educational ideas are what make Toeplitz's text interesting in the study of historiography of mathematics. In general, the ways historiography of mathematics and teaching of mathematics, even without an immediate concern for history, are deeply entangled and, in our view, worth attention both in historical and educational research.
Disciplined by the Discipline: A Social-Epistemic Fingerprint of the History of Science
Authors: Vanderstraeten Raf , Vandermoere Frederic 
Published: May 2015

ArgumentThe scientific system is primarily differentiated into disciplines. While disciplines may be wide in scope and diverse in their research practices, they serve scientific communities that evaluate research and also grant recognition to what is published. The analysis of communication and publication practices within such a community hence allows us to shed light on the dynamics of this discipline. On the basis of an empirical analysis ofIsis, we show how the process of discipline-building in history of science has led its practitioners to be socialized and sensitized in relatively strong intra-disciplinary terms – with minimal interdisciplinary openness.
Strange Birds: Ornithology and the Advent of the Collared Dove in Post-World War II Germany
Authors: Lachmund Jens 
Published: May 2015

ArgumentIn this paper I study the engagement of German ornithologists with the Collared Dove, a bird species of Asian origin that spread massively throughout Central Europe in the 1940s and 1950s. Never before had the spread of a single species attracted so much attention from European ornithologists. Ornithologists were not only fascinated by the exotic origin of the bird, but even more so by the unprecedented rapidity of its expansion. As it is argued in the paper, the advent of the bird created an outstanding opportunity for ornithologists to study the process of biogeographic range expansion. The paper traces how knowledge on the dove's expansion took shape in the social, discursive, and material practices of a large-scale observation campaign of German ornithologists (both amateurs and academics). The paper also argues that ornithologists’ observation practices have contributed to the construction of a benevolent cultural image of the Collared Dove. This sets the case of the Collared Dove apart from many recent debates in which newly arriving species have been framed as a threat to biodiversity. The paper contributes both to a historical understanding of scientific fieldwork as well as of the role of scientific knowledge in the shaping of cultural meanings of animals.
Modernizing Science: Between a Liberal, Social, and Socialistic University – The Case of Poland and the University of Łódź (1945–1953)
Authors: Zysiak Agata 
Published: May 2015

ArgumentThis paper examines the postwar reconstruction of the Polish academic system. It analyzes a debate that took place in the newly established university in the proletarian city of Łódź. The vision of the shape of the university was a bone of contention between the professors. This resulted in two contentious models of a university: “liberal” and “socialized.” Soon, universities were transformed into crucial institutions of the emerging communist state, where national history, ideology, and the future elite were produced and shaped. The social university was transformed into a socialistic university. Analysis of this process of transformation enables me to scrutinize the difficult clashes between the leftist intellectuals and the rising system of power that was not entirely hostile to them. The case of Poland also shows that sovietization did not mean solely a ruthless convergence of Central and Eastern Europe with a universal model most completely implemented in the USSR. Power hitting the ground was redeployed along various local interests, institutional conjunctures, and personal intransigencies. On a more universal level, I present this case in the context of the challenge of modernization and its many respective accommodations.