bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epithelial‐myoepithelial carcinoma occurrence in the site of previously treated ductal carcinoma in situ of the breast: Imaging features with histopathologic correlation, a case report and review of the literature
Authors: Hui Jessica , Zhan Xin , Bashir Amani , Policeni Fabiana , Kim Hsieh Su 
Published: August 2024

Key Clinical MessageEpithelial‐myoepithelial carcinoma of the breast is an extremely rare biphasic tumor. This report documents the first case of epithelial‐myoepithelial carcinoma presenting in the location of a previously treated ductal carcinoma in order to increase the awareness of this entity as a potential differential for recurrent breast lesions.AbstractEpithelial‐myoepithelial carcinoma of the breast is an exceedingly rare biphasic tumor, seldom documented in medical literature. This report describes the first known case of this entity at the site of a previously treated neoplasm in a 75‐year‐old female with a history of high‐grade ductal carcinoma in situ who presented with a new breast mass. Imaging demonstrated an oval shaped mass with microlobulated borders and hypoechoic echogenicity on ultrasound. Following multidisciplinary discussion, she underwent a mastectomy, revealing epithelial‐myoepithelial carcinoma with metaplastic squamous cell carcinoma. The patient began chemotherapy but discontinued due to poor tolerance and neurological complications. Generally, prognosis for epithelial‐myoepithelial carcinoma (World Health Organization Classification of Breast Tumors 2019, 8562/3) is highly variable, with limited available data suggesting that epithelial‐myoepithelial carcinoma may follow a course similar to that of breast adenocarcinomas with both hematogenous and lymphatic spread. Treatment typically involves curative excision, though the role of axillary lymph node sampling remains under discussion. This case underscores the need for vigilance in post‐treatment surveillance for breast cancer and highlights the importance of recognizing this entity in recurrent breast pathology.
Right sided posterior diaphragmatic hernia with liver incarceration: A case report
Authors: Alexi Boitsios , Sacha Lacroix , François Jehaes , Benoit Monami 
Published: August 2024

Key clinical MessageRight sided posterior diaphragmatic hernias are a rare diagnosis, especially in adult populations. This patient presented with right thoracic pain for 20 years before investigation. Imaging has provided an accurate diagnosis in this case. Repair can be done safely laparoscopically.
Silicalite‐1 Encapsulated Cu‐Based Catalyst for Selective Hydrogenation of Maleic Anhydride to γ‐Butyrolactone
Authors: Si Wuqiang , Liu Xuangan , Xu Zhiren , Chen Shuyao , Kou Shunli , Zhang Meixiao , Yao Su , Huang Weiguo , Xing Chuang , Sun Jian 
Published: August 2024

Abstractγ‐Butyrolactone (GBL) is a crucial product derived from the hydrogenation of maleic anhydride (MA). This study synthesized a Cu@Silicalite‐1 (Cu@S1) catalyst with 20 % Cu loading through a combination of impregnation and solid‐phase synthesis methods. The impact of Cu and Silicalite‐1 zeolite binding techniques on the MA hydrogenation was systematically investigated. The results show MA conversion of 96.2 % and GBL selectivity of 27.6 % at 240 °C, with sustained catalytic activity even after 150 hours of propionic acid corrosion on the Cu@S1 catalyst. The Silicalite‐1 zeolite plays a pivotal role in enhancing MA selective hydrogenation over Cu‐based catalysts, improving GBL selectivity, and minimizing the formation of propionic acid by‐products. The encapsulation of Cu particles by Silicalite‐1 zeolite facilitates improved dispersion of the metal and enhanced adsorption of reactants, thereby serving as a valuable catalyst for enhancing the acid and water resistance in GBL production.
S‐Scheme MnO2/Co3O4 Sugar‐Gourd Nanohybrids with Abundant Oxygen Vacancies for Efficient Visible‐Light‐Driven CO2 Reduction
Authors: Jin Linfeng , Yu Hangjing , Wang Chenhui , Guo Changfa , Wabaidur Saikh Mohammad , Zhong Yijun , Hu Yong 
Published: August 2024

AbstractConverting CO2 to carbon‐based fuels using solar energy via photocatalysis is a promising approach to boost carbon neutrality. However, the solar‐to‐chemical conversion efficiency is hampered by interconnected multiple factors including insufficient light absorption, low separation efficiency of photogenerated carriers as well as complex and sluggish surface reaction kinetics. Herein, we incorporate MnO2 nanowires and Co3O4 hollow polyhedrons with abundant oxygen vacancies (VO) into MnO2/Co3O4 sugar‐gourd nanohybrids for boosting CO2 photoreduction. The MnO2/Co3O4 nanohybrids not only display strong absorption in the visible–near infrared region, but also facilitate the separation of photogenerated carriers in terms of S‐scheme transfer pathway, supplying abundant electrons for CO2 reduction reaction. Furthermore, the presence of VO enhances the separation efficiency of photogenerated carriers and promotes the chemical adsorption to CO2 molecules. In addition, the interfacial electronic interaction between MnO2 and Co3O4 also contributes to the chemical adsorption and activation to CO2. Owing to the synergy of S‐scheme transfer pathway and VO, the MnO2/Co3O4 hybrids exhibit greatly enhanced photocatalytic activity towards CO2 reduction under the irradiation of visible light in comparison with bare MnO2 and Co3O4, delivering a CO evolution rate of 15.9 umol g−1 h−1 with a 100 % selectivity.
Dynamic Metabolic Bottlenecks of a Geobacter Sulfurreducens Bioelectrochemical System Studied Using Microfluidics and the Arrhenius Equation
Authors: Khodaparastasgarabad Nastaran , Couture Manon , Greener Jesse 
Published: August 2024

AbstractTo target development of bioelectrochemical systems, we developed an advanced microfluidic method to identify reaction bottlenecks in the metabolic activity of a pure‐culture Geobacter sulfurreducens electroactive biofilm (EAB). The microfluidic system was devised to include perpendicular flow orientation for improved boundary layer uniformity and was combined with an embedded 3‐electrode system to accurately apply a constant potential during the entire experimental duration which lasted se. A 3‐sensor temperature control system provided the basis of accurate temperature pulsing, which modified the EAB metabolic activity over short time intervals relative to the bacterial doubling rate. The system, together with the unique ability to control hydrodynamic, electrochemical, and thermal conditions, was used as the basis for an Arrhenius approach to obtain activation energy barrier values at different growth times, acetate concentrations, and flow rates. The results indicated that bottlenecks in the overall metabolic activity after 1 month of growth time were related to electron transfer through extracellular cytochrome c. After the EAB further matured to 4 months old, the bottleneck appeared to switch to enzyme‐driven acetate oxidation. Based on this hypothesis, we observed after 4‐months, that strong increases in effective enzyme concentration were primarily obtained by increasing flow rate, and secondarily by increasing acetate concentration
Attenuating Nucleophilicity of Titanocene Hydrides Beyond Steric Effects en Route to Fatty Alcohols
Authors: Höthker Sebastian , Goli Harie , Klare Sven , Krebs Tim , Schacht Jonathan H. , Gansäuer Andreas 
Published: August 2024

AbstractHere, we introduce a new class of titanocene catalysts for epoxide hydrosilylation that frustrates their hydridicity and thereby emphasizes their electron transfer reactivity. This unique attenuation of hydridicity is accomplished by introducing Lewis acidic silicon centers to the cyclopentadienyl ligands for an intramolecular coordination of the titanium‐bound hydride. The superiority of our rationally designed catalysts over classic titanocenes with alkyl‐substituted cyclopentadienyl ligands is demonstrated in the dramatically improved regioselectivity of the hydrosilylation of monosubstituted epoxides to primary alcohols.
Inherently Chiral Oligomers Based on Indole–Benzothiophene Core
Authors: Bonczak Bartlomiej , Grecchi Sara , Niamlaem Malinee , Salinas Gerardo , Cirilli Roberto , Arnaboldi Serena 
Published: August 2024

ABSTRACTIn recent years, transductors of chiral information based on conducting polymers have gained considerable attention. In particular, inherently chiral materials, which allow differentiation between the antipodes of a chiral analyte in terms of energetic variations, are highly desired. In this work, we successfully synthesized a novel inherently chiral oligomer based on an indole–benzothiophene core, namely, 2‐([2,2′‐bithiophen]‐5‐yl)‐3‐(2‐([2,2′‐bithiophen]‐5‐yl)benzo[b]thiophen‐3‐yl)‐N‐methylindole (BTIndT4). The electrochemical characterization evidences a stabilization of electrogenerated radical cations due to the presence of the indole group, which guides the oligomerization, producing well‐ordered polymeric matrices. Furthermore, the in situ electrochemical conductance analysis demonstrates a simultaneous intrachain and interchain transfer of charge carriers. Finally, the highly efficient enantiorecognition capabilities of the antipodes of the oligo‐BTIndT4 films toward the enantiomers of tryptophan and 3,4‐dihydroxyphenylalanine (DOPA), as model chiral analytes, were demonstrated.
Surface Defects, Ni3+ Species, Charge Transfer Resistance, and Surface Area Dictate the Oxygen Evolution Reaction Activity of Mesoporous NiCo2O4 Thin Films
Authors: Dubai Erik , Wu Qingyang , Lauterbach Stefan , Hofmann Jan P. , Einert Marcus 
Published: August 2024

AbstractFor catalyzing the oxygen evolution reaction, earth‐abundant materials with high activity and stability need to be developed. NiCo2O4 has been proven to show high OER activity, however facile and inexpensive techniques for preparation of this compound as mesostructured thin film, possessing a high surface area, is lacking. In this study, the sol‐gel synthesis of nanocrystalline, mesoporous spinel NiCo2O4 thin films by dip‐coating and soft‐templating using the evaporation‐induced self‐assembly approach and utilizing the tri‐block‐copolymer Pluronic® F‐127 as structure‐directing agent is reported. The morphology and crystallographic structure were thoroughly probed by various physicochemical characterization techniques collectively validating the development of uniform mesoporous NiCo2O4 architectures crystallizing exclusively in the cubic spinel phase after calcination in air at ether 300 °C, 400 °C, or 500 °C. The surface area of thin films increased from 300 °C to 400 °C owing to degradation of the organic template, while the growth of the mesopores from 400 °C to 500 °C resulted in significant decline of the overall (electrochemical) surface area. XPS investigations showed that the amount of octahedrally coordinated Ni3+ and defective (low‐coordinated) oxygen species increased for decreasing calcination temperatures. The nanomorphology and presence of catalytically active surface sites of the mesoporous NiCo2O4 electrodes were correlated with the electrochemical properties, presenting that the overall surface area, Ni3+ content, charge transfer resistance, and amount of defective oxygen sites collectively control the OER performance. After an optimized annealing procedure at 300 °C and chronopotentiometric analysis at 10 mA/cm2 for 1.5 h, a low overpotential of 330 mV vs. RHE at 10 mA/cm2 in alkaline solution was achieved. The results highlight the necessity of precise selection of the appropriate calcination temperature and tailoring of the nanostructure and electrochemical pre‐treatment conditions of NiCo2O4 sol‐gel thin films for adjusting the concentration of electrocatalytically active reaction sites.
Perceived Change Processes in Dialectical Behaviour Therapy From the Perspective of Clients With a Diagnosis or Traits of Borderline Personality Disorder: A Systematic Literature Review
Authors: Middlehurst Ruth , Moghaddam Nima , Dawson David L. , Reeve Andy 
Published: August 2024

ABSTRACTPurposeTo synthesise qualitative research on individuals diagnosed with (or reportedly showing traits of) borderline pattern personality disorder who underwent dialectical behaviour therapy, aiming to comprehend their perceptions of change processes and the therapy's effects.MethodA comprehensive literature search was conducted across multiple online databases and grey literature sources. Papers were quality appraised using an adapted version of the Critical Appraisal Skills Programme tool. A metaethnographic approach was employed during the synthesis.ResultsEleven studies met criteria for inclusion in the review. The main themes identified through the synthesis process were the impact of DBT, the supportive structure and the 1:1 therapy component.ConclusionsThe synthesis uncovered the importance of various processes within DBT that patients perceived as active ingredients for their change. Many of these processes aligned with proposed theoretical processes of change and quantitative research on DBT's effectiveness.
High‐selectivity wideband four‐way filtering power divider with input absorptive feature
Authors: Zhang Siran , Liu Hongmei , Wang Zhongbao , Fang Shaojun 
Published: August 2024

AbstractIn the paper, a high‐selectivity wideband four‐way filtering power divider with input absorptive feature is presented. It consists of two parallel‐coupled lines (CLs), two three‐coupled lines (TCLs), two open‐ended stepped branches, one absorptive branch, and two isolation resistors. The wideband filtering response is achieved by cascading the TCLs and CLs. While high selectivity is obtained by loading the open‐ended stepped branch, where two extra transmission zeros are generated. In addition, wide absorptive bandwidth with good isolations between adjacent output ports are realized by combining the absorptive branch with the isolation resistors. Equations are derived by using the two‐parity mode analysis, and main parameters are investigated in detail. For validation, a prototype was designed and fabricated. Test results show that the 3‐dB FBW can reach 87% with a 10‐dB input absorptive FBW of 200%. Besides, for the output ports with 10‐dB return loss and 10‐dB isolation, the FBWs are 94% and 91.5%, respectively. It also features high frequency selectivity and low insertion loss.
Exosomal circ‐0100519 promotes breast cancer progression via inducing M2 macrophage polarisation by USP7/NRF2 axis
Authors: Zhuang Minyu , Zhang Xiaoqiang , Ji Jie , Zhang Hongfei , Shen Li , Zhu Yanhui , Liu Xiaoan 
Published: August 2024

AbstractBackgroundBreast cancer (BC) is one of the most prevalent malignant tumours that threatens women health worldwide. It has been reported that circular RNAs (circRNAs) play an important role in regulating tumour progression and tumour microenvironment (TME) remodelling.MethodsDifferentially expression characteristics and immune correlations of circRNAs in BC were verified using high‐throughput sequencing and bioinformatic analysis. Exosomes were characterised by nanoparticle transmission electron microscopy and tracking analysis. The biological function of circ‐0100519 in BC development was demonstrated both in vitro and in vivo. Western blotting, RNA pull‐down, RNA immunoprecipitation, flow cytometry, and luciferase reporter were conducted to investigate the underlying mechanism.ResultsCirc‐0100519 was significant abundant in BC tumour tissues and related to poor prognosis. It can be encapsulated into secreted exosomes, thereby promoting BC cell invasion and metastasis via inducing M2‐like macrophages polarisation.Mechanistically, circ‐0100519 acted as a scaffold to enhance the interaction between the deubiquitinating enzyme ubiquitin‐specific protease 7 (USP7) and nuclear factor‐like 2 (NRF2) in macrophages, inducing the USP7‐mediated deubiquitination of NRF2. Additionally, HIF‐1α could function as an upstream effector to enhance circ‐0100519 transcription.ConclusionsOur study revealed that exosomal circ‐0100519 is a potential biomarker for BC diagnosis and prognosis, and the HIF‐1α inhibitor PX‐478 may provide a therapeutic target for BC.
Genetic erosion in domesticated barley and a hypothesis of a North African centre of diversity
Authors: Civáň Peter , Fricano Agostino , Russell Joanne , Pont Caroline , Özkan Hakan , Kilian Benjamin , Brown Terence A. 
Published: August 2024

AbstractBarley is one of the founder crops of the Neolithic transition in West Asia. While recent advances in genomics have provided a rather detailed picture of barley domestication, there are contradictory views on how the domestication process affected genetic diversity. We set out to revisit this question by integrating public DNA sequencing data from ancient barley and wide collections of extant wild and domesticated accessions. Using two previously overlooked approaches – analyses of chloroplast genomes and genome‐wide proportions of private variants – we found that the barley cultivated six millennia ago was genetically unique and more diverse when compared to extant landraces and cultivars. Moreover, the chloroplast genomes revealed a link between the ancient barley, an obscure wild genotype from north‐eastern Libya, and a distinct population of barley cultivated in Ethiopia/Eritrea. Based on these results, we hypothesize past existence of a wider North African population that included both wild and cultivated types and suffered from genetic erosion in the past six millennia, likely due to a rapid desertification that ended the Holocene African humid period. Besides providing clues about the origin of Ethiopian landraces, the hypothesis explains the post‐domestication loss of diversity observed in barley. Analyses of additional samples will be necessary to resolve the history of African barley and its contribution to the extant cultivated gene pool.
Masked invader in Iran! Habitat suitability analysis for invasive raccoon (Procyon lotor) in the west of Guilan Province
Authors: Hekmat Amin , Naderi Saeid , Zamani Wahid 
Published: August 2024

AbstractNowadays, in addition to the destruction and fragmentation of the world's habitats, invasive species, and damage caused by them, are one of the most important factors in the destruction of ecosystems. The raccoon (Procyon lotor) is a medium‐sized mammal that is placed in mid‐levels of the food web and can affect a wide range of species. Considering the damage done to local ecosystems by this invasive species, habitat assessment and determining the factors affecting its habitat suitability would be a key step in managing this species. In this study, using the MaxEnt model and examining 12 environmental parameters (elevation, slope, aspect, geological units, soil type, vegetation, land use, distance to villages, distance to main roads, distance to waterways, average temperature, and rainfall) in the west of Guilan Province, habitat suitability of this alien species was determined, and the most important factors affecting this suitability were investigated. Results showed that the validity value of the model (AUC) was estimated to be 0.852 and parameters such as distance to village (34.5%), elevation (24.2%), and land use (15.9%) are among the most important and effective factors. Also, the results showed that 0.60% of the study area has high suitability, 6.14% moderate, 24.87% low, and 68.36% unsuitable areas for raccoons. The overall result shows that despite the lack of vast favorable areas for this invasive species, an increase in the number and expansion of this species is very likely because of its omnivorous diet, high adaptability to different environments and conditions, as well as extensive niche. All of these factors cause raccoons to spread further in the region and consequently increase the risks and damages to the native ecosystem.
Plant resistance and predators influence the density dependence of herbivore survival and distribution of herbivory
Authors: Paniagua Montoya Monica , Forde Alexander J. , Inouye Brian , Underwood Nora 
Published: August 2024

AbstractPlant resistance and predators can influence density‐dependent survivorship and growth of herbivores, and their damage to plants. Although the independent effects of plant resistance and predators on herbivores and herbivory are well known, little is known about their interactive and density‐dependent effects on herbivores and the amount and distribution of damage on plants. These relationships are important for understanding how herbivore and plant populations influence each other. We used a laboratory density‐manipulation experiment to determine how plant resistance (three treatments: jasmonate‐insensitive, unmanipulated wild type, and jasmonate‐sprayed wild‐type plants) and predation (two treatments: predator or no predator) affect the survivorship and growth of an herbivore, as well as per capita damage and the distribution of damage on plants. We found evidence that the density dependence of herbivore survivorship was influenced by predators and an interactive effect of plant resistance and predation. Herbivore growth was reduced by higher plant resistance but was not density‐dependent nor affected by predation. Per capita plant damage was reduced by plant resistance, predation, and herbivore density. The within‐plant distribution of damage became more even with increasing herbivore density but was not affected by predation or the independent effect of plant resistance. The distribution of damage was also affected by an interaction between plant resistance and herbivore density; damage became less aggregated with density across all plant resistance treatments, but the decrease was strongest for the jasmonate‐insensitive plants. These results show that predators influence herbivore density dependence, and that plant resistance can affect the impact of predators on herbivores. Though plant resistance, predation, and herbivore density all reduced per capita herbivore damage to plants, only herbivore density and plant resistance affected the distribution of damage. Distributions of herbivory can influence plant success; documenting patterns of herbivory is an under‐appreciated avenue for integrating effects of plant resistance, predators, and herbivore density on plant–herbivore interactions.
Does habitat modification impact morphology, performance, and inflammatory responses in an amphibian with limited dispersal capacity (Lisssotriton helveticus)?
Authors: Bettencourt‐Amarante Soline , Furet Robin , Abensur Raphaëlle , Herrel Anthony 
Published: August 2024

AbstractThe environment of an organism exerts selective pressures that affect mobility, feeding, reproduction as well as predator–prey and conspecific interactions. Land use changes induced by human activities modify these selective pressures and may result in the adaptation of organisms. Amphibians are ectotherms that typically show a biphasic life cycle with an aquatic and terrestrial phase, which makes them particularly sensitive to environmental change. We studied the impact of habitat modifications on palmate newt populations in the Ile de France region across four types of habitats: urban, mixed, agricultural, and natural with at least two replicates for each habitat type. We measured the morphology of newts using callipers, quantified maximal running and swimming speed and acceleration using high‐speed video recordings, and quantified the swelling of the hind limb linked to an inflammatory reaction. Our results show that in urban habitats, newts are larger and heavier and have a better body condition. Females, moreover, have a larger head in natural habitats, possibly due to diet specialisation of females during the breeding season. In mixed and agricultural habitats, newts have longer limbs and show a tendency to run faster, possibly associated with the selective pressures on movement in mixed habitats. Differences in inflammatory responses were observed between sexes but not habitat types. Overall, our results show differences in morphology and trends for differences in performance in newts living in different habitats suggesting that animals are adapting to human‐induced changes in their environment.