bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Mesenchymal Stem Cell Transfusion Is Safe and Improves Liver Function in Acute-on-Chronic Liver Failure Patients
Authors: Shi Ming , Zhang Zheng , Xu Ruonan , Lin Hu , Fu Junliang , Zou Zhengsheng , Zhang Aimin , Shi Jianfei , Chen Liming , Lv Sa , He Weiping , Geng Hua , Jin Lei , Liu Zhenwen , Wang Fu-Sheng 
Published: October 2012

Abstract
Acute-on-chronic liver failure (ACLF) is a severe, life-threatening complication, and new and efficient therapeutic strategies for liver failure are urgently needed. Mesenchymal stem cell (MSC) transfusions have been shown to reverse fulminant hepatic failure in mice and to improve liver function in patients with end-stage liver diseases. We assessed the safety and initial efficacy of umbilical cord-derived MSC (UC-MSC) transfusions for ACLF patients associated with hepatitis B virus (HBV) infection. A total of 43 ACLF patients were enrolled for this open-labeled and controlled study; 24 patients were treated with UC-MSCs, and 19 patients were treated with saline as controls. UC-MSC therapy was given three times at 4-week intervals. The liver function, adverse events, and survival rates were evaluated during the 48-week or 72-week follow-up period. No significant side effects were observed during the trial. The UC-MSC transfusions significantly increased the survival rates in ACLF patients; reduced the model for end-stage liver disease scores; increased serum albumin, cholinesterase, and prothrombin activity; and increased platelet counts. Serum total bilirubin and alanine aminotransferase levels were significantly decreased after the UC-MSC transfusions. UC-MSC transfusions are safe in the clinic and may serve as a novel therapeutic approach for HBV-associated ACLF patients.
Le Train bleu : déraillement stylistique entre danse et musique ?
Authors: Harbec Jacinthe 
Published: October 2012

Sous-titré « opérette dansée », le balletLe Train bleu, élaboré à partir du livret de Jean Cocteau, de la musique de Darius Milhaud et de la chorégraphie de Bronislava Nijinska, est une parodie burlesque de la nouvelle société moderne des années 1920, axée sur l’hédonisme. Au lendemain de la création du 20 juin 1924, les critiques, tout en applaudissant les idées novatrices présentées dans l’argument, signalent une incohérence esthétique au sein de la production. Il est alors à se demander si la thématique de la modernité traitée sous l’angle de la frivolité poussée à son paroxysme a pu provoquer un déraillement stylistique entre le livret avant-gardiste, la musique passéiste à la Offenbach et la danse fondée essentiellement sur la pantomime. Avant de nous pencher sur cette problématique, nous examinerons brièvement les divers constituants artistiques du ballet, pour ensuite jeter un regard stylistique et formel sur la composition. Par la suite, nous aborderons la question d’indépendance entre la musique, le texte et la danse, nous menant finalement à discuter de la disparité stylistique et cinétique qui se crée entre la musique et la danse.
Francis Poulenc et la danse
Authors: Lacombe Hervé 
Published: October 2012

La danse constitue un axe important de la production de Poulenc et un modèle essentiel de son style, axe qu’il convient d’examiner globalement. Les références explicites (dans les titres) ou implicites aux danses irriguent toute son oeuvre, en dehors même des ballets, et contribuent à créer un imaginaire de la danse, lié à ses lectures et à ses souvenirs. Les danses populaires urbaines et les danses anciennes s’inscrivent logiquement dans l’esthétique néoclassique et permettent la constitution d’un « folklore personnel ». Le cas exemplaire des Biches, partition composée pour les Ballets russes de Diaghilev, permet à Poulenc de déployer sa propre poétique fondée sur une relation étroite nouant musique, danse et programme intime.
De nouvelles danses pour le vieux Monsieur B. Musique de J.-S. Bach avec chorégraphies et improvisations de la fin du XXe siècle
Authors: Schroedter Stephanie 
Published: October 2012

Un survol des développements choréomusicaux de la fin du XXe siècle révèle un nombre étonnant de productions en danse de tous genres et styles sur la musique de Jean-Sébastien Bach. Il ne fait aucun doute que Bach a été l’un des compositeurs les plus populaires chez les chorégraphes du siècle dernier, même si les oeuvres utilisées n’étaient pas forcément vouées à la danse. Ainsi, plusieurs faits peuvent expliquer ce phénomène. D’abord, les formes et les structures dans sa musique sont claires et évidentes, se prêtant admirablement aux chorégraphies. Deuxièmement, sa musique est très expressive, ce qui tient de la rhétorique et de la théorie des passions de son époque. Enfin, le compositeur a souvent été inspiré par les rythmes de la danse, même si sa musique est généralement beaucoup plus complexe que la musique de danse dite « idiomatique ». Nous comparerons deux démarches d’interprétation en danse afin de démontrer l’étendue possible des conceptions chorégraphiques de l’oeuvre de ce doyen de la musique occidentale. L’une est la création de Gerhard Bohner, chorégraphe allemand ayant évolué au sein du Tanztheater de Pina Bausch ; l’autre consiste en des improvisations de Steve Paxton.
Une lecture dialogique de l’improvisation libre et collective en musique actuelle et en contact-improvisation
Authors: Stévance Sophie 
Published: October 2012

Cet article propose une analyse de l’improvisation enmusique actuelle, un courant musical d’avant-garde qui s’est développé au Québec en 1979, à la lumière du contact-improvisation (mouvement chorégraphique apparu aux États-Unis en 1972). L’objectif est de comprendre la nature de ces arts improvisés où le rapport avec autrui en est le fondement. Comment l’individu et l’autre agissent-ils l’un sur l’autre? Comment prennent-ils la place qui leur revient dans le cadre d’un même processus conversationnel en cours? Ledialogismeselon Bakhtine, ici considéré comme métaphore, permet d’illustrer les interactions en jeu dans la musique actuelle et le contact-improvisation. Le dialogisme offre également l’occasion d’interroger la notion d’improvisation libre et collective, dont la musique actuelle et le contact improvisation sont les dignes représentants.
Successful clinical outcomes following decentralization of tertiary paediatric HIV care to a community‐based paediatric antiretroviral treatment network, Chiangrai, Thailand, 2002 to 2008
Authors: Hansudewechakul Rawiwan , Naiwatanakul Thananda , Katana Abraham , Faikratok Worawan , Lolekha Rangsima , Thainuea Vorapathu , McConnell Michelle S 
Published: October 2012

IntroductionMost paediatric antiretroviral treatments (ARTs) in Thailand are limited to tertiary care hospitals. To decentralize paediatric HIV treatment and care, Chiangrai Prachanukroh Hospital (CRH) strengthened a provincial paediatric HIV care network by training community hospital (CH) care teams to receive referrals of children for community follow‐up. In this study, we assessed factors associated with death and clinical outcomes of HIV‐infected children who received care at CRH and CHs after implementation of a community‐based paediatric HIV care network.MethodsClinical records were abstracted for all children who initiated ART at CRH. Paired Wilcoxon signed rank tests were used to assess CD4% and virological change among all children. Cox proportional hazard models were used to assess factors associated with death. Treatment outcomes (CD4%, viral load (VL) and weight‐for‐age Z‐score (WAZ)) were compared between CRH and CH children who met the criteria for analysis.ResultsBetween February 2002 and April 2008, 423 HIV‐infected children initiated ART and 410 included in the cohort analysis. Median follow‐up for the cohort was 28 months (interquartile range (IQR)=12 to 42); 169 (41%) children were referred for follow‐up at CH. As of 31 March 2008, 42 (10%) children had died. Baseline WAZ (<−2 (p=0.001)) and baseline CD4% (<5% (p=0.015)) were independently associated with death. At 48 months, 86% of ART‐naïve children in follow‐up had VL<400 copies/ml. For sub‐group analysis, 133 children at CRH and 154 at CHs were included for comparison. Median baseline WAZ was lower in CH children than in CRH children (p=0.001); in both groups, WAZ, CD4% and VL improved after ART with no difference in rate of WAZ and CD4% gain (p=0.421 and 0.207, respectively).ConclusionsChildren at CHs had more severe immunological suppression and low WAZ at baseline. Community‐ and tertiary care‐based paediatric ART follow‐ups result in equally beneficial outcomes with the strengthening of a provincial referral network between tertiary and community care. Nutrition interventions may benefit children in community‐based HIV treatment and care.
High‐Resolution Microfocus X‐Ray Computed Tomography for 3D Surface Roughness Measurements of Additive Manufactured Porous Materials
Authors: Kerckhofs Greet , Pyka Grzegorz , Moesen Maarten , Van Bael Simon , Schrooten Jan , Wevers Martine 
Published: October 2012

AbstractSince commercially available profiling systems fail when determining the surface roughness of porous materials, we propose a novel protocol for surface roughness quantification of 3D additive manufactured porous structures based on high‐resolution microfocus X‐ray computed tomography (micro‐CT) images. It allows to non‐destructively assess the roughness of these porous materials at the outer surface as well as inside the structure. The noise in the images and the spatial image resolution both have a significant effect on the accuracy of the micro‐CT‐based roughness measurements. Comparing the roughness parameters of flat substrates determined both with commercially available (optical and contact) profiling systems and the micro‐CT‐based roughness measurement protocol shows that micro‐CT can be applied accurately and in a robust manner for surface roughness quantification of 3D additive manufactured porous materials with a micro‐scale roughness. Depending on the dimensions of the roughness, the micro‐CT acquisition parameters, i.e., frame averaging and spatial image resolution, need to be fine‐tuned. Submicron‐scale roughness can currently not be quantified.
Micropatterned Freestanding Superelastic TiNi Films
Authors: Lima de Miranda Rodrigo , Zamponi Christiane , Quandt Eckhard 
Published: October 2012

AbstractMicropatterned freestanding superelastic TiNi films in the thickness range between 20 and 100 µm are attractive materials for medical in vivo applications. Micropatterning of these materials by UV lithography and etching is a challenging task, as wet etching has severe design limitations due to its isotropic nature while dry etching shows much to low etching rates. This study presents a method to fabricate freestanding TiNi films (with thicknesses higher than 20 µm) with a minimum feature size 5 µm based on UV lithography, sacrificial layer and wet etching technology. This method was successfully applied to the fabrication of TiNi films with 50 µm thickness and 25 µm feature size. These superelastic films showed remarkable tensile strengths up to 1100 MPa and elongations upon fracture of more than 40%.
Colloidal Stabilization of Calcium Carbonate Prenucleation Clusters with Silica
Authors: Kellermeier Matthias , Gebauer Denis , Melero‐García Emilio , Drechsler Markus , Talmon Yeshayahu , Kienle Lorenz , Cölfen Helmut , García‐Ruiz Juan Manuel , Kunz Werner 
Published: October 2012

AbstractCalcium carbonate precipitation proceeds via a complex multistage scenario involving neutral ion clusters as precursors and amorphous phases as intermediates, which finally transform to crystals. Although the existence of stable clusters in solution prior to nucleation has been demonstrated, the molecular mechanisms by which they precipitate are still obscure. Here, direct insight into the processes that drive the transformation of individual clusters into amorphous nanoparticles is provided by progressive colloidal stabilization of different transient states in silica‐containing environments. Nucleation of calcium carbonate in the presence of silica can only take place via cluster aggregation at low pH values. At higher pH, prenucleation clusters become colloidally stabilized and cannot aggregate. Nucleation through structural reorganization within the clusters is not observed under these conditions, indicating that this pathway is blocked by kinetic and/or thermodynamic means. The degree of stabilization against nucleation is found to be sufficient to allow for a dramatic enrichment of solutions with prenucleation clusters and enable their isolation into the dry state. This approach renders direct analyses of the clusters by conventional techniques possible and is thus likely to facilitate deeper insight into the chemistry and structure of these elusive species in the future.
Microorganism‐Derived Heteroatom‐Doped Carbon Materials for Oxygen Reduction and Supercapacitors
Authors: Zhu Hui , Yin Jiao , Wang Xiaolei , Wang Hongyu , Yang Xiurong 
Published: October 2012

AbstractHeteroatom‐doped carbon (HDC) has attracted tremendous attention due to its promising application in energy conversion and storage. Herein, due to its abundance high rate of reproduction, the microorganism, Bacillus subtilis, is selected as a precursor. An effective ionothermal process is adopted to produce the HDCs. Using acid activation, the obtained sample exhibits excellent electrocatalytic activity, long‐term stability, and excellent resistance to crossover effects in oxygen reduction. Additionally, the base‐treated sample exhibits superior performance in capacitors to most commercially available carbon materials. Even at a high current density, a relatively high capacitance is retained, indicating a great potential for direct application in energy storage.
Smart Design of Stable Extracellular Matrix Mimetic Hydrogel: Synthesis, Characterization, and In Vitro and In Vivo Evaluation for Tissue Engineering
Authors: Oommen Oommen P. , Wang Shujiang , Kisiel Marta , Sloff Marije , Hilborn Jöns , Varghese Oommen P. 
Published: October 2012

AbstractThe simplicity and versatility of hydrazone crosslinking has made it a strategy of choice for the conjugation of bioactive molecules. However, the labile nature of hydrazone linkages and reversibility of this coupling reaction restricts its full potential. Based on the fundamental understanding of hydrazone stability, this problem is circumvented by resonance‐stabilization of a developing N2 positive charge in a hydrazone bond. A novel chemistry is presented to develop a resilient hydrazone bond that is stable and non‐ reversible under physiological conditions. A carbodihydrazide (CDH) type hydrazide derivative of the biomolecule forms intrinsically stabilized hydrazone‐linkages that are nearly 15‐fold more stable at pH 5 than conventional hydrazone. This chemoselective coupling reaction is catalyst‐free, instantaneous, and virtually non‐cleavable under physiological conditions, therefore can serve as a catalyst‐free alternative to click chemistry. This novel crosslinking reaction is used to tailor a hyaluronan hydrogel, which delivered exceptional hydrolytic stability, mechanical properties, low swelling, and controlled enzymatic degradation. These desired characteristics are achieved without increasing the chemical crosslinking. The in vivo evaluation of this hydrogel revealed neo‐bone with highly ordered collagen matrix mimicking natural bone regeneration. The proximity ligation assay or PLA is used to detect blood vessels, which highlighted the quality of engineered tissue.
The Effect of He Implantation on the Tensile Properties and Microstructure of Cu/Fe Nano‐Bicrystals
Authors: Landau Peri , Guo Q. , Hattar K. , Greer J. R. 
Published: October 2012

AbstractIn situ uniaxial tensile experiments on as‐fabricated and helium‐implanted 100 nm‐diameter Cu/Fe bicrystals unearth the effect of individual face‐centred‐cubic/body‐centred‐cubic (fcc‐bcc) interfaces on improving radiation‐damage tolerance and helium absorption. Arrays of nanotensile specimens, each containing a single Cu grain in the bottom half and a single Fe grain on top, were fabricated by templated electron‐beam lithography and electrodeposition. Helium is implanted at 200 keV to a dose of 1014 ion/cm2 nominally into the interface region. High‐resolution, site‐specific transmission electron microscopy (TEM) and through‐focus analysis reveal that the interfaces are nonplanar and contain ≈5 nm‐spaced He bubbles with diameters of 1–2 nm. Nanomechanical experimental results show that the irradiated samples exhibit yield and ultimate tensile strengths more than 60% higher than the as‐fabricated ones, while they retain comparable ductility. Tensile failure always occurs gradually, along the interfaces, with no noticeable shape localization. The absence of brittle failure in He‐irradiated metals might be explained, in part, by the inability of the small He bubbles to serve as sufficient stress concentrators for cracking. In addition, the non‐orthogonal orientation of the interfaces with respect to the loading axes results in the development of both normal‐ and shear‐stress components. Tensile loading along the pillar axes may cause those interfacial regions subjected to normal stresses to detach, while the inclined regions, subjected to shear, to carry plastic deformation until final fracture.
PdAg Nanorings Supported on Graphene Nanosheets: Highly Methanol‐Tolerant Cathode Electrocatalyst for Alkaline Fuel Cells
Authors: Liu Minmin , Lu Yizhong , Chen Wei 
Published: October 2012

AbstractDue to the high costs, slow reaction kinetics, and methanol poisoning of platinum‐based cathode catalysts, designing and exploring non‐Pt or low‐Pt cathode electrocatalysts with a low cost, high catalytic performance, and high methanol‐tolerance are crucial for the commercialization of fuel cells. Here, a facile method to fabricate a system of PdAg nanorings supported by graphene nanosheets is demonstrated; the fabrication is based on the galvanic displacement reaction between pre‐synthesized Ag nanoparticles and palladium ions. X‐ray diffraction and high‐resolution transmission electron microscopy show that the synthesized PdAg nanocrystals exhibit a ring‐shaped hollow structure with an average size of 27.49 nm and a wall thickness of 5.5 nm. Compared to the commercial Pd–C catalyst, the PdAg nanorings exhibit superior properties as a cathode electrocatalyst for oxygen reduction. Based on structural and electrochemical studies, these advantageous properties include efficient usage of noble metals and a high surface area because of the effective utilization of both the exterior and interior surfaces, high electrocatalytic performance for oxygen reduction from the synergistic effect of the alloyed PdAg crystalline phase, and most importantly, excellent tolerance of methanol crossover at high concentrations. It is anticipated that this synthesis of graphene‐based PdAg nanorings will open up a new avenue for designing advanced electrocatalysts that are low in cost and that exhibit high catalytic performance for alkaline fuel cells.
A General and Efficient Method for the Alkoxycarbonylation of α‐Chloro Ketones
Authors: Wahl Benoit , Bonin Hélène , Mortreux André , Giboulot Steven , Liron Frédéric , Poli Giovanni , Sauthier Mathieu 
Published: October 2012

AbstractThe alkoxycarbonylation of α‐chloro ketones with carbon monoxide in alcoholic solvents could be optimized to generate β‐keto esters in high yields using much lower catalyst loadings than previously reported in the literature. Among the different screened parameters, the nature of the ligand proved to be the most crucial one, the Xantphos ligand affording the highest yields. The scope of the reaction could then be extended to a wide variety of chloro ketones with different types of alcohols.
Plasmon‐Active Nano‐Aperture Window Electrodes for Organic Photovoltaics
Authors: Stec Helena M. , Hatton Ross A. 
Published: October 2012

AbstractA lithography free approach to fabricating optically thin (∼10 nm) noble metal electrodes with a dense array of sub‐wavelength apertures is reported. These nano‐structured electrodes support surface plasmon resonances which couple strongly with visible light concentrating it near to the electrode surface. They are also remarkably robust and can be fabricated on glass and plastic substrates with a sheet resistance of <15 Ω sq−1. As the window electrode in solution processed and vacuum deposited organic photovoltaics (OPV) the photocurrent is increased by as much as 28% as compared to identical devices without apertures, demonstrating that the apertures do not need to have a tight size and/or shape distribution to be effective. As a drop‐in replacement for the indium‐tin oxide electrode in flexible OPV these plasmon‐active electrodes offer superior performance; 5.1% vs. 4.6%, demonstrating that this class of electrode is a truly viable alternative to conducting oxide window electrodes for OPV.
Association of KIBRA with episodic and working memory: A meta‐analysis
Authors: Milnik Annette , Heck Angela , Vogler Christian , Heinze Hans‐Jochen , de Quervain Dominique J.‐F. , Papassotiropoulos Andreas 
Published: October 2012

AbstractWWC1 was first implicated in human cognition through a genome wide association study in 2006 that reported an association of the intronic single nucleotide polymorphism (SNP) rs17070145 with episodic memory performance. WWC1 encodes the protein KIBRA, which is almost ubiquitously expressed. Together with its binding partners, KIBRA is assumed to play a role in synaptic plasticity. T‐allele carriers of SNP rs17070145 have been reported to outperform individuals that are homozygous for the C‐allele in episodic memory tasks. Here we report two random effects meta‐analyses testing the association of rs17070145 with episodic and working memory. All currently available population‐based association studies that investigated effects of rs17070145 on episodic or working memory were included in the analyses. Where performance measures for multiple domain‐specific tasks were available for a given study population, averaged effect size estimates were calculated. The performed meta‐analyses relied on 17 samples that were tested for episodic memory performance (N = 8,909) and 9 samples that had performed working memory tasks (N = 4,696). We report a significant association of rs17070145 with both episodic (r = 0.068, P = 0.001) and working memory (r = 0.035, P = 0.018). In summary, our findings indicate that SNP rs17070145 located within KIBRA explains 0.5% of the variance for episodic memory tasks and 0.1% of the variance for working memory tasks in samples of primarily Caucasian background. © 2012 Wiley Periodicals, Inc.
Genetic variant inKIAA0319, but not inDYX1C1, is associated with risk of dyslexia: An integrated meta‐analysis
Authors: Zou Li , Chen Wei , Shao Shanshan , Sun Zhao , Zhong Rong , Shi Junxin , Miao Xiaoping , Song Ranran 
Published: October 2012

AbstractDYX1C1 andKIAA0319have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth. The −3G > A inDYX1C1and the 931C > T inKIAA0319were of special interest for dyslexia but with inconsistent results. We performed a meta‐analysis integrating case–control and transmission/disequilibrium test (TDT) studies to clearly discern the effect of these two variants in dyslexia. Data from case–control and TDT studies were analyzed in an allelic model using the Catmap software. In overall meta‐analysis, the pooled OR for the −3A allele and the 931T allele was 0.68 (95% CI = 0.25–1.87,Pheterogeneity = 0.000) and 0.87 (95% CI = 0.78–0.98,Pheterogeneity = 0.125), respectively. The stratified analysis showed that the between‐study heterogeneity regarding the −3G > A polymorphism might be accounted by the publication year. Additionally, the sensitivity analysis of −3G > A polymorphism indicated the stability of the result. In conclusion, our results suggested that the 931C > T variant inKIAA0319, but not the −3G > A inDYX1C1, was significantly associated with the risk of dyslexia. © 2012 Wiley Periodicals, Inc.