bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Unique European Governance Structure : Office of the High Representative in Bosnia and Herzegovina Basis of Its Legitimacy and Controversial Accountability
Authors: Gutic-Bjelica Biljana 
Published: July 2024

In order to assess the successes and failures of Bosnia and Herzegovina’s (BiH) challenging road towards a fully functional democratic state aiming at membership in the European Union (EU), this paper examines the state-building process in BiH, and the transition from the post-Dayton political development, the work of the interim, ad-hoc political institution of the Office of the High Representative (OHR) in BiH, as well as the justification – if any - of its future existence and operation. Guided by the coordination dilemma, the research question of this paper is a reflection on the challenges of self-enforcing democratic institutions and how the OHR substitutes for it. This paper claims that the original purpose of the Dayton Peace Agreement (DPA) was to create a powerful yet limited institution of the OHR, one that is to be given sufficient power to institute behaviour, but is prevented from abusing its power. However, this purpose deviated in the years that followed the signing of the DPA, creating and institution which doings resemble liberal imperialism. The hypothesis of the paper is that the OHR has been abusing its power and that it is time to close it because it is no more a substitute for the self-enforcing democratic institutions. This paper claims that the problem of political officials’ lack of respect for the political and economic rights of citizens they administer, as investigated by Weingast, is one of the central features of the operation of the OHR in BiH. The novelty of the paper lies in the attempt to test if OHR could be a case that could serve as a very good field to test Weingast’s model (1997).
ASUHAN KEPERAWATAN DENGAN DIAGNOSA KEPERAWATAN KONFUSI AKUT DENGAN PENERAPAN STIMULASI AUDITORI TERHADAP PERUBAHAN NILAI GLASGOW COMA SCALE (GCS) PADA PASIEN STROKE HEMORAGIK DENGAN PENURUNAN KESADARAN DI RUANG INTENSIVE CARE UNIT (ICU) RSUD ABDOEL WAHAB SJAHRANIE SAMARINDA
Authors: Syifa Zahrotusy , Dwiyana Ana , Hadi Fauzi Muhammad 
Published: July 2024

Pendahuluan : Stroke dapat menyebabkan penurunan kesadaran. Pada kasus stroke dengan penurunan kesadaran dapat mengakibatkan pasien mengalami kematian, defisit neurologi, semakin lamanya waktu perawatan, dan akan meningkatkan biaya perawatan. Pasien stroke yang mengalami penurunan kesadaran memerlukan terapi non farmakologi sebagai terapi tambahan penunjang proses penyembuhan, salah satu intervensi non farmakologi yakni stimulasi sensori auditori. Stimulasi sensori auditori merupakan suatu intervensi dimana pasien yang menerima intervensi mendengarkan suara yang direkam secara digital, rekaman tersebut merupakan rekaman suara orang yang dikenal dekat dengannya, rekaman berisi suatu kisah yang berkesan dengan pasien. Tujuan : untuk mengetahui perubahan nilai Glasgow Coma Scale (GCS) sebelum dan sesudah dilakukan penerapan Stimulasi Auditori. Metode : Metode analisis yang digunakan dimulai dari pengkajian, diagnosa, intervensi, implementasi dan evaluasi keperawatan.. Hasil : Kasus kelolaan pada Tn. S (55 tahun) dengan diagnosa medis Stroke Hemoragik intracerebral Hemmorhage Post EVD hari pertama sebelum dilakukan tindakan Stimulasi auditori rekaman suara Istrinya, GCS = 5, setelah dilakukan tindakan GCS = 6. Hari kedua sebelum dilakukan tindakan GCS = 6, setelah dilakukan tindakan GCS = 5. Hari ketiga sebelum dilakukan tindakan GCS = 5, setelah dilakukan tindakan GCS = 5. Kasus Resume pada Tn.E (36 tahun), dengan diagnosa medis Stroke Hemoragik Intracerebral Hemmorhage HT Emergency hari pertama sebelum dilakukan tindakan Stimulasi auditori rekaman suara Orang Tuanya, GCS = 4, setelah dilakukan tindakan GCS = 5. Hari kedua sebelum dilakukan tindakan GCS = 4, setelah dilakukan tindakan GCS = 5. Hari ketiga sebelum dilakukan tindakan GCS = 4, setelah dilakukan tindakan GCS = 4. Kasus Resume Ny.N (59 tahun), dengan diagnosa Stroke Hemoragik Intracerebral Hemmorhage HT Emergency hari pertama sebelum dilakukan tindakan Stimulasi auditori rekaman suara Anaknya, GCS = 5, setelah dilakukan tindakan GCS = 6. Hari kedua sebelum dilakukan tindakan GCS = 5, setelah dilakukan tindakan GCS = 6. Hari ketiga sebelum dilakukan tindakan GCS = 6, setelah dilakukan tindakan GCS = 7. Kesimpulan : Hasil yang didapatkan dari ke tiga pasien tersebut dapat dilihat bahwa setelah dilakukan Intervensi Stimulasi Auditori tidak terjadi perubahan Glasgow Coma Scale (GCS) yang signifikan
HUBUNGAN POSISI IBU SAAT MENYUSUI DENGAN MUSCULOSKELETAL DISORDERS (MSDs) DI POSYANDU BALITA DESA TUMPUK KECAMATAN WLINGI BLITAR
Authors: Hargiani Fransisca Xaveria , Rulyana Nindi , Fariz Achmad , Halimah Nurul 
Published: July 2024

Pendahuluan: Menyusui merupakan salah satu fitrah seorang perempuan hal ini juga tertuang dalam organisasi dunia yang merekomendasikan menyusui selama 2 tahun. Ibu menyusui mengadopsi berbagai posisi menyusui berbeda yang menimbulkan musculoskeletal disoders. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan posisi ibu saat menyusui dengan musculoskeletal disorders.. Metode: Desain penelitian ini adalah cross sectional dengan populasi semua ibu menyusui di Posyandu Balita di desa Tumpuk Kecamatan Wlingi Blitar sebanyak 135 orang dengan jumlah sampel 50 orang dengan teknik purposive sampling dan memenuhi kriteria inklusi dan eksklusi, instrument penelitian menggunakan nordic body map (NBM). Variabel independen musculoskeletal disoders, variabel dependen posisi ibu saat menyusui. Kemudian data tersebut dianalisis menggunakan uji statistik tabulating dan spearman dengan taraf koefisien korelasi. Hasil: Pada penelitian ini menggunakan uji korelasi dengan uji spearman menunjukaan angka koefisien korelasi sebesar 0.216. Kesimpulan: tidak ada hubungan antara posisi ibu menyusui dengan musculoskeletal disorder dan posisi menyusui yang sering dilakukan ibu adalah berbaring dengan tingkat musculoskeletal disoders kategori keluhan ringan di Posyandu Balita Desa Tumpuk Kecamatan Wlingi Blitar.
ANALISA BEBAN KERJA TERHADAP KEJADIAN NYERI LEHER DAN NYERI PUNGGUNG BAWAH PADA FISIOTERAPIS DI RUMAH SAKIT WILAYAH JAWA TIMUR
Authors: Revani Hilda Dea , Dewi Prima , Wardani Ratna , Ellina Agusta Dian 
Published: July 2024

Pendahuluan: Gangguan sistem muskuloskeletal menjadi salah satu permasalahan kesehatan yang paling sering terjadi di industri dan di dunia. Sebagian penyakit yang ada bisa jadi merupakan akibat dari kegiatan mekanika atau pergerakan tubuh yang tidak baik. Dalam memberikan tindakan fisioterapi kepada pasien, fisioterapis melakukan kegiatannya dengan menerapkan tindakan manual material handling. Manual material handling (MMH) dalam rentang waktu tertentu yang dapat menimbulkan masalah pada area muskuloskeletal jika tidak dilakukan secara prinsip ergonomis. Tujuan: menganalisa hubungan antara beban kerja dengan kejadian nyeri pada leher dan punggung bawah pada fisioterapis yang bekerja di rumah sakit di wilayah Jawa Timur. Metode: menggunakan metode deskriptif kuantitatif, yang bertujuan untuk mendapatkan pemahaman umum tentang realitas dari sudut pandang partisipan. Penelitian ini bersifat observasional dimana peneliti hanya melakukan pengamatan dengan menggunakan google form tanpa memberikan intervensi terhadap variabel yang akan diteliti, dan bersifat analitik untuk mengidentifikasi hubungan sebab akibat antara variabel yang berfungsi sebagai penyebab (variabel bebas) dan akibat (variabel terikat). Pendekatan menggunakan cross sectional, dimana proses pengumpulan data baik variabel dependen maupun independen dilakukan secara bersamaan pada suatu waktu tertentu. Hasil: ada hubungan antara beban kerja dengan nyeri leher (p value : 0,001) dan nyeri punggung bawah (p value: 0,02) pada fisioterapis di rumah sakit wilayah Jawa Timur. Kesimpulan: perlu melakukan stretching di saat tidak menangani pasien, agar meminimalisir terjadi nyeri punggung bawah dan nyeri leher yang dapat berakibat kurang baik.
PENGARUH PEMBERIAN LATIHAN CORE STABILITY TERHADAP PERUBAHAN LINGKAR PINGGANG MAHASISWI STIKES KESDAM IV / DIPONEGORO SEMARANG
Authors: Luberto Purna , Pradita Angria , Endaryanto Agung Hadi , Fariz Achmad 
Published: July 2024

Pendahuluan: Latihan Core Stability menggunakan prinsip motor learning untuk memfasilitasi koordinasi dari otot bagian dalam dari spine. Pemberian latihan Core Stability juga dapat membantu aktivasi otot perut bagian dalam, mengembalikan fungsi otot yang lemah dan menambah kemampuan untuk menunjang dan mengontrol tulang belakang serta panggul. Tujuan: Penelitian ini bertujuan untuk mengidentifikasi pengaruh latihan Core Stability terhadap perubahan lingkar pinggang mahasiswi .Metode: Desain penelitian ini adalah eksperimental pre-posttest dengan sampel penelitian 20 mahasiswi Stikes Kesdam IV Diponegoro Semarang pada bulan Juni - Juli 2023 yang memenuhi kriteria inklusi dengan teknik purposive sampling. Pengukuran panjang lingkar pinggang menggunakan pita pengukur sebelum dan sesudah treatment fisioterapi, yakni pemberian latihan Core Stability setiap 5 kali seminggu selama 4 minggu. Hasil: Diperoleh nilai p = 0,000 (p < 0,01) antara perubahan panjang lingkar pinggang sebelum dan sesudah diberikan latihan Core Stability. Kesimpulan: Terdapat pengaruh latihan Core Stability terhadap perubahan panjang lingkar pinggang.
Seasonal and Spatial Distribution of Zooplankton Communities with Relation to some Physico-Chemical Parameters in the South East Coast of Bangladesh
Authors: Uddin Mohammad Muslem , Rahman Mohammad Shafiqur , Islam Md. Hasibul , Shamsuzzaman Mostafa 
Published: July 2024

Seasonal and spatial distribution of zooplankton communities in relation with some physico-chemical parameters in the south eastern coastal waters of Bangladesh was carried out from January 2016 to November 2016. Zooplankton samples were collected from seven different selected stations covering various ecosystems, viz.: Riverine (Bhola, Barishal & Chandpur), Offshore Island water (Sandwip & Hatia) and Nearshore (Cox’s bazar & Naf River) regions. In total 33 genera were recorded during sampling periods and the highest abundance of zooplankton were recorded at Naf River (331.318 ind/m3) and the lowest at Chandpur (22.6414ind/m3) during post-monsoon. In pre-monsoon the highest abundance was recorded at Sandwip (31.49435ind/m3) and the lowest at Bhola (8.239854ind/m3). During monsoon the highest abundance was recorded at Cox’s Bazar (51.64085ind/m3) and the lowest at Barishal (4.389972ind/m3). A total of 24, 22 and 32 individuals (genera) of zooplankton identified during monsoon, pre-monsoon and post-monsoon respectively from all sampling stations. Calanoida, Cyclopoida, Fish larvae, Lucifer and Shrimp Zoea were common in every sampling station. Dictoyptera was the only species found in marine water. The statistical analysis of water quality parameters as temperature, pH, salinity, transparency, DO, TDS and TSS indicated the substantial relationship with seasonal and spatial distribution, diversity and abundance of zooplankton. Diversity index also indicated seasonal and spatial variation of zooplankton communities in the south eastern coastal waters of Bangladesh.
The Chittagong Univ. J. B. Sci.,Vol. 10(1 &2):95-119, 2020
The Beneish M-Score Model in Detecting Fraudulent Financial Reporting: The Hexagon Perspective Theory
Authors: Kusuma Sherawanti Permata , Oktafiyani Melati , Pamungkas Imang Dapit , Ratnawati Juli 
Published: July 2024

This research aims to investigate the effect of fraud on fraudulent financial reports (FFR) using the hexagon theory. The seven factors were financial stability, external pressure, ineffective monitoring, auditor changes, director changes, arrogance, and collusion. This study has a population of health companies listed on the IDX in 2018-2021. This study uses a quantitative approach. Based on the logistic regression analysis, the study finds that financial stability, change director, and arrogance affect FFR. On the other hand, external pressure, ineffective monitoring, auditor change, and collusion do not affect FFR. Keywords:Fraudulent financial reporting, Hexagon theory, Beneish M-Score
Rapid isolation method for extracellular vesicles based on Fe3O4@ZrO2
Authors: Ma Cuidie , Xu Zhihui , Hao Kun , Fan Lingling , Du Wenqian , Gao Zhan , Wang Chong , Zhang Zheng , Li Ningxia , Li Qi , Gao Qi , Yu Changyuan 
Published: July 2024

Extracellular vesicles (EVs) are pivotal in intercellular communication, disease mechanisms. Despite numerous methods for EVs isolation, challenges persist in yield, purity, reproducibility, cost, time, and automation. We introduce a EVs isolation technique using Fe3O4@ZrO2 beads, leveraging ZrO2-phosphate interaction. The results indicated that EVs were efficiently separated from large volumes of samples in 30 minutes without preconcentration. Our method demonstrated capture efficiency (74%–78%) compared to ultracentrifugation, purity (97%), and reproducibility (0.3%–0.5%), with excellent linearity (R2 &gt; 0.99). EVs from urine samples showed altered expression of miRNAs. The logistic regression model achieved an AUC of 0.961, sensitivity of 0.92, and specificity of 0.94. With potential for automation, this magnetic bead-based method holds promise for clinical applications, offering an efficient and reliable tool for EVs research and clinical studies.
Research on wire icing simulation technology considering the weights of meteorological elements
Authors: Zhou Fangrong , Huai Xiaowei , Yan Pengcheng , Jiang Xingliang , Pan Hao , Ma Yi , Geng Hao 
Published: July 2024

Wire icing seriously threatens the safety and reliability of power systems. Strengthening the simulation study of icing thickness is crucial for disaster prevention and mitigation, as well as the adjustment of power system operation strategies. The meteorological elements, including air temperature, precipitation and wind speed, are the key factors affecting wire icing. In this study, the meteorological elements related to icing thickness are obtained by numerical models, and the relationship between these elements and icing thickness observations is established to develop a model for simulating icing thickness. The model is applied to study typical icing in Yunnan Province, China. The results indicate that the deviation of the simulated icing thickness is about 2 mm, smaller than that from the traditional model. Batch experiments demonstrate that the new model developed in this research is applicable to the vast majority of 238 observation stations in Yunnan Province for icing thickness simulation, and the method can yield lower simulation deviations.
Platelet indices and inflammatory bowel disease: a Mendelian randomization study
Authors: Li Hong-yang , Liu Tie-mei 
Published: July 2024

BackgroundPlatelets play a significant role in the innate and adaptive processes of immunity and inflammation. Inflammatory bowel disease (IBD) is an autoimmune disease that is widely understood to be caused by a combination of genetic predisposition, aberrant immune responses, etc.MethodsTo examine the relationships between genetically determined platelet indices and IBD, we conducted a Mendelian randomization (MR) study. Data associated with platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) were used from the UK Biobank. The outcome data, including IBD, Crohn’s disease (CD), ulcerative colitis (UC), were from the FinnGen database. The inverse variance-weighted (IVW), MR-Egger, weighted median methods were used for MR analyses.ResultsThe MR estimations from the IVW approach show a significant connection between PLT and IBD. Similarly, PCT and IBD have a relationship following the IVW and MR-Egger approaches. While PLT and PCT have strong relationships with CD, according to the findings of all three approaches respectively. Nevertheless, PDW was the only relevant indicator of UC. The only significant result was IVW’s.ConclusionOur findings suggest that the fluctuation of platelet indicators is of great significance in the development of IBD. PLT and PCT have a close association with IBD and CD, respectively; PDW only has a connection with UC. Platelets play an important role in the progression of IBD (UC, CD).
Developing an advanced diagnostic model for hepatocellular carcinoma through multi-omics integration leveraging diverse cell-death patterns
Authors: Wang Chengbang , Yang Guanglin , Feng Guanzheng , Deng Chengen , Zhang Qingyun , Chen Shaohua 
Published: July 2024

IntroductionHepatocellular carcinoma (HCC), representing more than 80% of primary liver cancer cases, lacks satisfactory etiology and diagnostic methods. This study aimed to elucidate the role of programmed cell death-associated genes (CDRGs) in HCC by constructing a diagnostic model using single-cell RNA sequencing (scRNA-seq) and RNA sequencing (RNA-seq) data.MethodsSix categories of CDRGs, including apoptosis, necroptosis, autophagy, pyroptosis, ferroptosis, and cuproptosis, were collected. RNA-seq data from blood-derived exosomes were sourced from the exoRBase database, RNA-seq data from cancer tissues from the TCGA database, and scRNA-seq data from the GEO database. Subsequently, we intersected the differentially expressed genes (DEGs) of the HCC cohort from exoRBase and TCGA databases with CDRGs, as well as DEGs obtained from single-cell datasets. Candidate biomarker genes were then screened using clinical indicators and a machine learning approach, resulting in the construction of a seven-gene diagnostic model for HCC. Additionally, scRNA-seq and spatial transcriptome sequencing (stRNA-seq) data of HCC from the Mendeley data portal were used to investigate the underlying mechanisms of these seven key genes and their association with immune checkpoint blockade (ICB) therapy. Finally, we validated the expression of key molecules in tissues and blood-derived exosomes through quantitative Polymerase Chain Reaction (qPCR) and immunohistochemistry experiments.ResultsCollectively, we obtained a total of 50 samples and 104,288 single cells. Following the meticulous screening, we established a seven-gene diagnostic model for HCC, demonstrating high diagnostic efficacy in both the exoRBase HCC cohort (training set: AUC = 1; testing set: AUC = 0.847) and TCGA HCC cohort (training set: AUC = 1; testing set: AUC = 0.976). Subsequent analysis revealed that HCC cluster 3 exhibited a higher stemness index and could serve as the starting point for the differentiation trajectory of HCC cells, also displaying more abundant interactions with other cell types in the microenvironment. Notably, key genes TRIB3 and NQO1 displayed elevated expression levels in HCC cells. Experimental validation further confirmed their elevated expression in both tumor tissues and blood-derived exosomes of cancer patients. Additionally, stRNA analysis not only substantiated these findings but also suggested that patients with high TRIB3 and NQO1 expression might respond more favorably to ICB therapy.ConclusionsThe seven-gene diagnostic model demonstrated remarkable accuracy in HCC screening, with TRIB3 emerging as a promising diagnostic tool and therapeutic target for HCC.
Retroductal dexamethasone administration promotes the recovery from obstructive and inflammatory salivary gland dysfunction
Authors: Hwang Seungyeon , Cho Jae-Min , Yoon Yeo-Jun , Seo Sunyoung , Hong Yongpyo , Lim Jae-Yol 
Published: July 2024

IntroductionSalivary gland dysfunction, often resulting from salivary gland obstruction-induced inflammation, is a prevalent condition. Corticosteroid, known for its anti-inflammatory and immunomodulatory properties, is commonly prescribed in clinics. This study investigates the therapeutic implications and potential side effects of dexamethasone on obstructive sialadenitis recovery using duct ligation mice and salivary gland organoid models.MethodsFunctional and pathological changes were assessed after administering dexamethasone to the duct following deligation 2 weeks after maintaining ligation of the mouse submandibular duct. Additionally, lipopolysaccharide- and tumor necrosis factor-induced salivary gland organoid inflammation models were established to investigate the effects and underlying mechanisms of action of dexamethasone.ResultsDexamethasone administration facilitated SG function restoration, by increasing salivary gland weight and saliva volume while reducing saliva lag time. Histological evaluation revealed, reduced acinar cell atrophy and fibrosis with dexamethasone treatment. Additionally, dexamethasone suppressed pro-inflammatory cytokines IL-1β and TNF expression. In a model of inflammation in salivary gland organoids induced by inflammatory substances, dexamethasone restored acinar markers such as AQP5 gene expression levels, while inhibiting pro-inflammatory cytokines TNF and IL6, as well as chemokines CCL2, CXCL5, and CXCL12 induction. Macrophages cultured in inflammatory substance-treated media from salivary gland organoid cultures exhibited pro-inflammatory polarization. However, treatment with dexamethasone shifted them towards an anti-inflammatory phenotype by reducing M1 markers (Tnf, Il6, Il1b, and Cd86) and elevating M2 markers (Ym1, Il10, Cd163, and Klf4). However, high-dose or prolonged dexamethasone treatment induced acino-ductal metaplasia and had side effects in both in vivo and in vitro models.ConclusionsOur findings suggest the effectiveness of corticosteroids in treating obstructive sialadenitis-induced salivary gland dysfunction by regulating pro-inflammatory cytokines.