bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Regio‐ and Stereocontrolled Nucleophilic Trifluoromethylthiolation of Morita—Baylis—Hillmann Carbonates.
Authors: Dai Xiaoyang , Cahard Dominique 
Published: May 2015

AbstractAppropriate conditions to obtain various thermodynamically more stable primary allylic SCF3‐derivatives as well as one example for a kinetically more stable secondary allylic SCF3‐product are elaborated.
ChemInform Abstract: Stereodivergent Synthesis of Arylcyclopropylamines by Sequential C—H Borylation and Suzuki—Miyaura Coupling.
Authors: Miyamura Shin , Araki Misaho , Suzuki Takayoshi , Yamaguchi Junichiro , Itami Kenichiro 
Published: May 2015

AbstractA step‐economical and stereodivergent synthesis of 2‐arylcyclopropylamines (ACPAs) through a C(sp3)—H borylation and Suzuki—Miyaura coupling sequence has been developed.
ChemInform Abstract: Aerobic Oxynitration of Alkynes with tBuONO and TEMPO.
Authors: Dutta Uttam , Maity Soham , Kancherla Rajesh , Maiti Debabrata 
Published: May 2015

AbstractThe reaction tolerates a wide range of functionalized aryl alkynes and hetaryl alkynes, di‐ and triethynylbenzenes.
ChemInform Abstract: Self‐Propagated Lossen Rearrangement Induced by a Catalytic Amount of Activating Agents under Mild Conditions.
Authors: Hoshino Yujiro , Shimbo Yuki , Ohtsuka Naoya , Honda Kiyoshi 
Published: May 2015

AbstractThe acetic anhydride‐catalyzed rearrangement of aromatic and aliphatic hydroxamic acids to the corresponding amines is described.
ChemInform Abstract: Selective Aryl α‐Diimine/Palladium‐Catalyzed Bis‐alkoxycarbonylation of Olefins for the Synthesis of Substituted Succinic Diesters.
Authors: Fini Francesco , Beltrani Michela , Mancuso Raffaella , Gabriele Bartolo , Carfagna Carla 
Published: May 2015

AbstractAromatic and aliphatic olefins are converted into α‐substituted succinic acid diesters by using oxidative alkoxycarbonylation with carbon monoxide and alcohol.
ChemInform Abstract: Application of Bidentate Oxazoline—Carbene Ligands with Planar and Central Chirality in Asymmetric β‐Boration of α,β‐Unsaturated Esters.
Authors: Niu Zonghong , Chen Jianqiang , Chen Zhen , Ma Manyuan , Song Chun , Ma Yudao 
Published: May 2015

AbstractA series of chiral bidendate oxazoline‐carbene precursors, based on [2.2]paracyclophane, is developed and applied in copper‐catalyzed β‐boration of α,β‐unsaturated esters.
ChemInform Abstract: A Fast and Benign Synthesis of α‐Aminonitriles by Reusable Immobilized AlCl3 on γ‐Al2O3.
Authors: Pamar M. Geeta , Govender P. , Pillay K. , Abrahamse H. , Nanjundaswamy H. M. 
Published: May 2015

AbstractAlCl3 immobilized on γ‐Al2O3 is an efficient, safe, and environmentally friendly catalyst for the synthesis of a wide range of α‐aminonitriles (IV) via Strecker reaction.
ChemInform Abstract: Application of Bis(oxazoline) in Asymmetric β‐Amination of Chalcones.
Authors: Deng Tao , Wang Hongjun , Cai Chun 
Published: May 2015

Abstractβ‐Imidoketones (III) are enantioselectively synthesized using a chiral bis‐(oxazoline) ligand.
ChemInform Abstract: KOtBu‐Mediated Aerobic Transition‐Metal‐Free Regioselective β‐Arylation of Indoles: Synthesis of β‐(2‐/4‐Nitroaryl)‐indoles.
Authors: Kumar Shailesh , Rathore Vandana , Verma Ajay , Prasad Ch. Durga , Kumar Amit , Yadav Abhimanyu , Jana Sadhan , Sattar Moh. , Meenakshi Meenakshi , Kumar Sangit 
Published: May 2015

Abstractβ‐Arylation in unprotected indoles can be achieved chemo‐ and regioselectively by employing KOtBu at room temperature in air without using a transition metal catalyst and aryl halide coupling partner.
ChemInform Abstract: Regio‐ and Diastereoselective Vinylogous Mannich Addition of 3‐Alkenyl‐2‐oxindoles to a α‐Fluoroalkyl Aldimines.
Authors: Liu Yingle , Yang Yi , Huang Yangen , Xu Xiu‐Hua , Qing Feng‐Ling 
Published: May 2015

AbstractThe protocol tolerates a variety of functional groups.
ChemInform Abstract: Bifunctional Catalysts Based on m‐Phenylene‐Bridged Porphyrin Dimer and Trimer Platforms: Synthesis of Cyclic Carbonates from Carbon Dioxide and Epoxides.
Authors: Maeda Chihiro , Taniguchi Tomoya , Ogawa Kanae , Ema Tadashi 
Published: May 2015

AbstractHighly active bifunctional diporphyrin and triporphyrin catalysts are synthesized through Stille coupling reactions.
ChemInform Abstract: Magnetically Separable Nano CeO2: A Highly Efficient Catalyst for Ligand Free Direct C—H Arylation of Heterocycles.
Authors: Shelkar Radheshyam S. , Balsane Kishor E. , Nagarkar Jayashree M. 
Published: May 2015

AbstractThe catalytic system proves valuable for the 2‐functionalization of benzoxazole and benzothiazole with various aryl iodides, aryl bromides, and the cheaper aryl diazonium tetrafluoroborates.
ChemInform Abstract: Polymer Anchored Ruthenium Complex: A Highly Active and Recyclable Catalyst for One‐Pot Azide—Alkyne Cycloaddition and Transfer‐Hydrogenation of Ketones under Mild Conditions.
Authors: Molla Rostam Ali , Roy Anupam Singha , Ghosh Kajari , Salam Noor , Iqubal Md Asif , Tuhina K. , Islam Sk Manirul 
Published: May 2015

AbstractThe polymer anchored ruthenium catalyst can be easily recovered by filtration and reused for six consecutive cycles with consistent catalytic activity.
ChemInform Abstract: Synthesis of 5‐Cyanopyrazolo[1,5‐a]pyridine Derivatives via Tandem Reaction and Their Optical Properties.
Authors: Wang Bin , Su Fan , Jia Jiong , Wu Fan , Zhang Shu‐Yao , Ge Yan‐Qing , Wang Jason , Wang Jian‐Wu 
Published: May 2015

AbstractA novel tandem reaction of 5‐carbonylpyrazole derivatives with 4‐bromobut‐2‐enenitrile provides access to pyrazolopyridine derivatives displaying blue fluorescence.
ChemInform Abstract: Ag(I)‐Catalyzed Tandem [6 + 3] Annulation/Isomerization of Isocyanoacetates with Fulvenes: An Expedient Approach to Synthesize Fused Dihydropyridines.
Authors: He Zhao‐Lin , Wang Chun‐Jiang 
Published: May 2015

AbstractThe first Ag(I)‐catalyzed [6 + 3] cycloaddition/isomerization of fulvenes and isocyanoacetates for the facile access to fused dihydropyridines with high functionality is reported.
ChemInform Abstract: Synthesis of 5,7‐Diarylpyrazolo[1,5‐a]pyrimidines via KOH Mediated Tandem Reaction of 1H‐Pyrazol‐3‐amines and Chalcones.
Authors: Kaswan Pinku , Pericherla Kasiviswanadharaju , Purohit Deepshikha , Kumar Anil 
Published: May 2015

AbstractThe title process offers operational simplicity, short reaction times, and good functional group tolerance.
ChemInform Abstract: Copper‐Catalyzed Stereoselective Aminoboration of Bicyclic Alkenes.
Authors: Sakae Ryosuke , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: May 2015

AbstractA copper‐catalyzed, exo‐selective aminoboration of bicyclic alkenes, including oxa‐ and azabenzonorbornadienes, is developed.
ChemInform Abstract: First Total Synthesis of a Guanidine Alkaloid Nitensidine D Using Immobilized Ionic Liquid, Microwaves and Formamidinesulfinic Acid.
Authors: Shallu Shallu , Sharma M. L. , Singh Jasvinder 
Published: May 2015

AbstractA total synthesis of the guanidine alkaloid nitensidine D (I) is reported, which uses geraniol as starting material.
ChemInform Abstract: Unconventional, Chemically Stable, and Soluble Two‐Dimensional Angular Polycyclic Aromatic Hydrocarbons: From Molecular Design to Device Applications
Authors: Zhang Lei , Cao Yang , Colella Nicholas S. , Liang Yong , Bredas Jean‐Luc , Houk K. N. , Briseno Alejandro L. 
Published: May 2015

AbstractReview: 51 refs.
High‐Performance Liquid Chromatographic Enantioseparation of Cyclic β‐Amino Acids on Zwitterionic Chiral Stationary Phases Based on Cinchona Alkaloids
Authors: Ilisz István , Gecse Zsanett , Lajkó Gyula , Forró Enikõ , Fülöp Ferenc , Lindner Wolfgang , Péter Antal 
Published: May 2015

AbstractStereoselective high‐performance liquid chromatographic separations of eight sterically constrained cyclic β‐amino acid enantiomer pairs were carried out using the newly developed Cinchona alkaloid‐based zwitterionic chiral stationary phases Chiralpak ZWIX(+) and ZWIX(−). The effects of the mobile phase composition, the nature and concentrations of the acid and base additives, the counterions and temperature on the separations were investigated. The changes in standard enthalpy, Δ(ΔH°), entropy, Δ(ΔS°), and free energy, Δ(ΔG°), were calculated from the linear van't Hoff plots derived from the ln α vs. 1/T curves in the studied temperature range (10–50°C). The values of the thermodynamic parameters depended on the nature of the selectors and the structures of the analytes. Unusual temperature behavior was observed on the ZWIX(−) column: decreased retention times were accompanied by increased separation factors with increasing temperature. On the ZWIX(+) column only enthalpically, whereas on the ZWIX(−) column both enthalpically and entropically driven separations were observed. The elution sequence was determined in all cases and was observed to be the opposite on ZWIX(+) and on ZWIX(−). Chirality 27:563–570, 2015. © 2015 Wiley Periodicals, Inc.
Glycans in Medicinal Chemistry: An Underexploited Resource
Authors: Fernández‐Tejada Alberto , Cañada F. Javier , Jiménez‐Barbero Jesús 
Published: May 2015

AbstractThe biological relevance of glycans as mediators of key physiological processes, including disease‐related mechanisms, makes them attractive targets for a wide range of medical applications. Despite their important biological roles, especially as molecular recognition elements, carbohydrates have not been fully exploited as therapeutics mainly due to the scarcity of structure–activity correlations and their non‐drug‐like properties. A more detailed understanding of the complex carbohydrate structures and their associated functions should contribute to the development of new glycan‐based pharmaceuticals. Recent significant progress in oligosaccharide synthesis and chemical glycobiology has renewed the interest of the medicinal chemistry community in carbohydrates. This promises to increase our possibilities to harness them in drug discovery efforts for the development of new and more effective, synthetic glycan‐based therapeutics and vaccines.
A Phytochemical–Halogenated Quinoline Combination Therapy Strategy for the Treatment of Pathogenic Bacteria
Authors: Abouelhassan Yasmeen , Garrison Aaron T. , Bai Fang , Norwood Verrill M. , Nguyen Minh Thu , Jin Shouguang , Huigens Robert W. 
Published: May 2015

AbstractWith the continued rise of drug‐resistant bacterial infections coupled with the current discouraging state of the antibiotic pipeline, the need for new antibacterial agents that operate through unique mechanisms compared with conventional antibiotics and work in synergy with other agents is at an all‐time high. We have discovered that gallic acid, a plant‐derived phytochemical, dramatically potentiates the antibacterial activities of several halogenated quinolines (up to 11 800‐fold potentiation against Staphylococcus aureus) against pathogenic bacteria, including drug‐resistant clinical isolates. S. aureus demonstrated the highest sensitivity towards gallic acid–halogenated quinoline combinations, including one halogenated quinoline that demonstrated potentiation of biofilm eradication activity against a methicillin‐resistant S. aureus (MRSA) clinical isolate. During our studies, we also demonstrated that these halogenated quionlines operate through an interesting metal(II) cation‐dependent mechanism and display promising mammalian cytotoxicity.
Evolution of the hippocampus in reptiles and birds
Authors: Striedter Georg F. 
Published: May 2015

ABSTRACTAlthough the hippocampus is structurally quite different among reptiles, birds, and mammals, its function in spatial memory is said to be highly conserved. This is surprising, given that structural differences generally reflect functional differences. Here I review this enigma in some detail, identifying several evolutionary changes in hippocampal cytoarchitecture and connectivity. I recognize a lepidosaurid pattern of hippocampal organization (in lizards, snakes, and the tuatara Sphenodon) that differs substantially from the pattern of organization observed in the turtle/archosaur lineage, which includes crocodilians and birds. Although individual subdivisions of the hippocampus are difficult to homologize between these two patterns, both lack a clear homolog of the mammalian dentate gyrus. The strictly trilaminar organization of the ancestral amniote hippocampus was gradually lost in the lineage leading to birds, and birds expanded the system of intrahippocampal axon collaterals, relative to turtles and lizards. These expanded collateral axon branches resemble the extensive collaterals in CA3 of the mammalian hippocampus but probably evolved independently of them. Additional examples of convergent evolution between birds and mammals are the loss of direct inputs to the hippocampus from the primary olfactory cortex and the general expansion of telencephalic regions that communicate reciprocally with the hippocampus. Given this structural convergence, it seems likely that some similarities in the function of the hippocampus between birds and mammals, notably its role in the ability to remember many different locations without extensive training, likewise evolved convergently. The currently available data do not allow for a strong test of this hypothesis, but the hypothesis itself suggests some promising new research directions. J. Comp. Neurol. 524:496–517, 2016. © 2015 Wiley Periodicals, Inc.
Anatomical organization of the visual dorsal ventricular ridge in the chick (Gallus gallus): Layers and columns in the avian pallium
Authors: Ahumada‐Galleguillos Patricio , Fernández Máximo , Marin Gonzalo J. , Letelier Juan C. , Mpodozis Jorge 
Published: May 2015

ABSTRACTThe dorsal ventricular ridge (DVR) is one of the main components of the sauropsid pallium. In birds, the DVR is formed by an inner region, the nidopallium, and a more dorsal region, the mesopallium. The nidopallium contains discrete areas that receive auditory, visual, and multisensory collothalamic projections. These nidopallial nuclei are known to sustain reciprocal, short‐range projections with their overlying mesopallial areas. Recent findings on the anatomical organization of the auditory DVR have shown that these short‐range projections have a columnar organization that closely resembles that of the mammalian neocortex. However, it is unclear whether this columnar organization generalizes to other areas within the DVR. Here we examine in detail the organization of the visual DVR, performing small, circumscribed deposits of neuronal tracers as well as intracellular fillings in brain slices. We show that the visual DVR is organized in three main laminae, the thalamorecipient nucleus entopallium; a dorsally adjacent nidopallial lamina, the intermediate nidopallium; and a contiguous portion of the ventral mesopallium, the mesopallium ventrale. As in the case of the auditory DVR, we found a highly topographically organized system of reciprocal interconnections among these layers, which was formed by dorsoventrally oriented, discrete columnar bundles of axons. We conclude that the columnar organization previously demonstrated in the auditory DVR is not a unique feature but a general characteristic of the avian sensory pallium. We discuss these results in the context of a comparison between sauropsid and mammalian pallial organization. J. Comp. Neurol. 523:2618–2636, 2015. © 2015 Wiley Periodicals, Inc.
C‐5 Propynyl Modifications Enhance the Mechanical Stability of DNA
Authors: Aschenbrenner Daniela , Baumann Fabian , Milles Lukas F. , Pippig Diana A. , Gaub Hermann E. 
Published: May 2015

AbstractIncreased thermal or mechanical stability of DNA duplexes is desired for many applications in nanotechnology or ‐medicine where DNA is used as a programmable building block. Modifications of pyrimidine bases are known to enhance thermal stability and have the advantage of standard base‐pairing and easy integration during chemical DNA synthesis. Through single‐molecule force spectroscopy experiments with atomic force microscopy and the molecular force assay we investigated the effect of pyrimidines harboring C‐5 propynyl modifications on the mechanical stability of double‐stranded DNA. Utilizing these complementary techniques, we show that propynyl bases significantly increase the mechanical stability if the DNA is annealed at high temperature. In contrast, modified DNA complexes formed at room temperature and short incubation times display the same stability as non‐modified DNA duplexes.
Activation of brain steroidogenesis and neurogenesis during the gonadal differentiation in protandrous black porgy, Acanthopagrus schlegelii
Authors: Lin Chien‐Ju , Fan‐Chiang Yi‐Chun , Dufour Sylvie , Chang Ching‐Fong 
Published: May 2015

ABSTRACTThe early brain development, at the time of gonadal differentiation was investigated using a protandrous teleost, black porgy. This natural model of monosex juvenile fish avoids the potential complexity of sexual dimorphism. Brain neurogenesis was evaluated by histological analyses of the diencephalon, at the time of testicular differentiation (in fish between 90 and 150 days after hatching). Increases in the number of both Nissl‐stained total brain cells, and Pcna‐immunostained proliferative brain cells were observed in specific area of the diencephalon, such as ventromedialis thalami and posterior preoptic area, revealing brain cell proliferation. qPCR analyses showed significantly higher expression of the radial glial cell marker blbp and neuron marker bdnf. Strong immunohistochemical staining of Blbp and extended cellular projections were observed. A peak expression of aromatase (cyp19a1b), as well as an increase in estradiol (E2) content were also detected in the early brain. These data demonstrate that during gonadal differentiation, the early brain exhibits increased E2 synthesis, cell proliferation, and neurogenesis. To investigate the role of E2 in early brain, undifferentiated fish were treated with E2 or aromatase inhibitor (AI). E2 treatment upregulated brain cyp19a1b and blbp expression, and enhanced brain cell proliferation. Conversely, AI reduced brain cell proliferation. Castration experiment did not influence the brain gene expression patterns and the brain cell number. Our data clearly support E2 biosynthesis in the early brain, and that brain E2 induces neurogenesis. These peak activity patterns in the early brain occur at the time of gonad differentiation but are independent of the gonads. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 121–136, 2016
Absence of both Sos‐1 and Sos‐2 in peripheral CD4+ T cells leads to PI3K pathway activation and defects in migration
Authors: Guittard Geoffrey , Kortum Robert L. , Balagopalan Lakshmi , Çuburu Nicolas , Nguyen Phan , Sommers Connie L. , Samelson Lawrence E. 
Published: May 2015

Sos‐1 and Sos‐2 are ubiquitously expressed Ras‐guanine exchange factors involved in Erk‐MAP kinase pathway activation. Using mice lacking genes encoding Sos‐1 and Sos‐2, we evaluated the role of these proteins in peripheral T‐cell signaling and function. Our results confirmed that TCR‐mediated Erk activation in peripheral CD4+ T cells does not depend on Sos‐1 and Sos‐2, although IL‐2‐mediated Erk activation does. Unexpectedly, however, we show an increase in AKT phosphorylation in Sos‐1/2dKO CD4+ T cells upon TCR and IL‐2 stimulation. Activation of AKT was likely a consequence of increased recruitment of PI3K to Grb2 upon TCR and/or IL‐2 stimulation in Sos‐1/2dKO CD4+ T cells. The increased activity of the PI3K/AKT pathway led to downregulation of the surface receptor CD62L in Sos‐1/2dKO T cells and a subsequent impairment in T‐cell migration.
The ironic effect of national identification on support for collective action
Authors: Mähönen Tuuli Anna , Jasinskaja‐Lahti Inga 
Published: May 2015

AbstractPrevious research has suggested that dual and superordinate identities are not only prerequisites of collective action among minority group members but they can also be associated with greater acceptance of the ingroup's disadvantaged position. In this three‐wave study among Ingrian Finnish migrants from Russia to Finland (N=153T1−85T3), we tested the indirect association between superordinate national identification (T1) and support for collective action (T3), via perceived permeability of group boundaries (T2). Support for collective action was operationalized as one's personal willingness, and the perceived need of the Russian‐speaking community, to engage in it. When controlling for the direct association between Russian minority identification and support for collective action, perceived permeability was shown to mediate the negative association between Finnish national identification and support for community's collective action. Thus, being close to the majority may make immigrants perceive group boundaries as more permeable and be less inclined to improve their group's position.
The Processing of Food Stimuli in Abnormal Eating: A Systematic Review of Electrophysiology
Authors: Wolz Ines , Fagundo Ana B. , Treasure Janet , Fernández‐Aranda Fernando 
Published: May 2015

AbstractTo update the knowledge about attentional processing of food stimuli, a systematic review of electrophysiological studies was conducted using PubMed, PsychInfo and Web of Knowledge (2000–2014). Twenty‐one studies were included into a qualitative synthesis. Presentation of food and control pictures was used to analyze event‐related potentials related to sensory processing and motivated attention. Results show consistent attentional bias towards food pictures compared with neutral pictures for patient and control groups. Group comparisons between individuals with abnormal‐eating and healthy‐eating participants were more inconsistent. Results suggest that temporal differences in the millisecond range are essential for the understanding of visual food processing. In obesity, early attention engagement to food is followed by relatice disengagement. Loss of control eating, as well as external and emotional eating, are associated with a sustained maintenance of attention towards high‐caloric food. There is a lack of studies in anorexia nervosa, bulimia nervosa and binge eating disorder. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
Higher‐order surface treatment for discontinuous Galerkin methods with applications to aerodynamics
Authors: Silveira A. S. , Moura R. C. , Silva A. F. C. , Ortega M. A. 
Published: May 2015

SummaryWhen dealing with high‐order numerical methods, an adequate treatment of curved surfaces is required not only to guarantee that the expected high‐order is maintained in the vicinity of surfaces but also to avoid steady‐state convergence issues. Among the variety of high‐order surface treatment techniques that have been proposed, the ones employing NURBS (non‐uniform rational B‐splines) to describe curved surfaces can be considered superior both in terms of accuracy and compatibility with computer‐aided design softwares. The current study describes in detail the integration of NURBS‐based geometry description in a high‐order solver based on the discontinuous Galerkin formulation. Particularly, this work also discusses how and why NURBS curves of very high order can be employed within standard NURBS‐based boundary treatment techniques to yield reduced implementation complexity and computational overhead. Theoretical estimates are provided along with numerical experiments in order to support the proposed approach. Minding engineering applications in the context of compressible aerodynamics, additional simulations are addressed as numerical examples to illustrate the advantages of using higher‐order NURBS in practical situations. Copyright © 2015 John Wiley & Sons, Ltd.