bluuebunny/crossref_metadata_2025_split huggingface dataset:
Five‐year clinical follow‐up of a randomized comparison of a polymer‐free sirolimus‐eluting stent versus a polymer‐based paclitaxel‐eluting stent in patients with diabetes mellitus (LIPSIA Yukon trial)
Authors: Stiermaier Thomas , Heinz Anja , Schloma Denis , Kleinertz Klaus , Dänschel Wilfried , Erbs Sandra , Linke Axel , Boudriot Enno , Lauer Bernward , Schuler Gerhard , Thiele Holger , Desch Steffen 
Published: July 2013

ObjectivesThe long‐term performance of polymer‐free stent systems in patients with diabetes mellitus has not been investigated extensively. This study reports long‐term results of the LIPSIA Yukon trial which compared the polymer‐free sirolimus‐eluting Yukon Choice stent with the polymer‐based paclitaxel‐eluting Taxus Liberté stent in this subpopulation. At 9 months, the Yukon Choice stent failed to show non‐inferiority in terms of the primary end point late lumen loss, while no significant difference in clinical outcome was detected.Methods and ResultsThe LIPSIA Yukon trial randomized 240 patients with diabetes mellitus to a polymer‐free sirolimus eluting stent (Yukon Choice, Translumina) versus a polymer‐based paclitaxel‐eluting stent (Taxus Liberté, Boston Scientific). Clinical follow‐up was conducted with a standardized telephone follow‐up and all events were centrally adjudicated. Follow‐up was available for 98.3% of patients after a median of 5.0 years. The incidence of all‐cause death (16.9% versus 14.0%, P = 0.67), respectively definite or presumed cardiovascular death (7.6% versus 8.8%, P = 0.94) were similar in the Yukon Choice and the Taxus Liberté group. There were no significant differences in the rates of myocardial infarction (9.3% versus 7.9%, P = 0.88), definite stent thrombosis (0.8% versus 0.9%, P = 1.0), target lesion revascularization (15.3% versus 15.8%, P = 1.0), target vessel revascularization (18.6% versus 23.7%, P = 0.44), non‐target vessel revascularization (18.6% versus 26.3%, P = 0.21), and stroke (3.4% versus 4.4%, P = 0.96) between patients assigned to the Yukon Choice and the Taxus Liberté stent.ConclusionAt 5 years of follow‐up, clinical outcome was similar between the polymer‐free sirolimus‐eluting Yukon Choice stent and the polymer‐based paclitaxel‐eluting Taxus Liberté stent. © 2013 Wiley Periodicals, Inc.
Unusual Stepwise Protonation and J‐Aggregation of meso‐Tetrakis(N‐methylpyridinium‐4‐yl)porphine on Binding Poly(sodium vinylsulfonate)
Authors: Castriciano Maria Angela , Samperi Mario , Camiolo Salvatore , Romeo Andrea , Monsù Scolaro Luigi 
Published: July 2013

AbstractThe binding of a tetracationic porphyrin to a highly charged polymer like poly(sodium vinylsulfonate) has been investigated over a wide pH range and under various experimental conditions. We present evidence that, depending on the pH, the high electrostatic field exerted by the polymer stabilizes the diprotonated form of the free base porphyrin at unusual pH values or otherwise causes the formation of H‐type aggregates. In particular, at a low polymer concentration, lowering the pH at first allows the formation of the diacid species then it determines its reorganization in close‐packed J‐type aggregates. The employment of various metallo‐derivatives of the title porphyrin enables a better insight into the nature of all the detected species.
Versatile Reactivity of Scorpionate‐Anchored YttriumDialkyl Complexes towards Unsaturated Substrates
Authors: Yi Weiyin , Zhang Jie , Zhang Fangjun , Zhang Yin , Chen Zhenxia , Zhou Xigeng 
Published: July 2013

AbstractA series of unusual chemical‐bond transformations were observed in the reactions of high active yttriumdialkyl complexes with unsaturated small molecules. The reaction of scorpionate‐anchored yttriumdibenzyl complex [TpMe2Y(CH2Ph)2(thf)] (1, TpMe2=tri(3,5‐dimethylpyrazolyl)borate) with phenyl isothiocyanate led to CS bond cleavage to give a cubane‐type yttrium–sulfur cluster, {TpMe2Y(μ3‐S)}4 (2), accompanied by the elimination of PhNC(CH2Ph)2. However, compound 1 reacted with phenyl isocyanate to afford a C(sp3)H activation product, [TpMe2Y(thf){μ‐η1:η3‐OC(CHPh)NPh}{μ‐η3:η2‐OC(CHPh)NPh}YTpMe2] (3). Moreover, compound 1 reacted with phenylacetonitrile at room temperature to produce γ‐deprotonation product [(TpMe2)2Y]+[TpMe2Y(N=CCHPh)3]− (6), in which the newly formed NCCHPh ligands bound to the metal through the terminal nitrogen atoms. When this reaction was carried out in toluene at 120 °C, it gave a tandem γ‐deprotonation/insertion/partial‐TpMe2‐degradation product, [(TpMe2Y)2(μ‐Pz)2{μ‐η1:η3‐NC(CH2Ph)CHPh}] (7, Pz=3,5‐dimethylpyrazolyl).
A Robust One‐Compartment Fuel Cell with a Polynuclear Cyanide Complex as a Cathode for Utilizing H2O2 as a Sustainable Fuel at Ambient Conditions
Authors: Yamada Yusuke , Yoneda Masaki , Fukuzumi Shunichi 
Published: July 2013

AbstractA robust one‐compartment H2O2 fuel cell, which operates without membranes at room temperature, has been constructed by using a series of polynuclear cyanide complexes that contain Fe, Co, Mn, and Cr as cathodes, in sharp contrast to conventional H2 and MeOH fuel cells, which require membranes and high temperatures. A high open‐circuit potential of 0.68 V was achieved by using Fe3[{CoIII(CN)6}2] on a carbon cloth as the cathode and a Ni mesh as the anode of a H2O2 fuel cell by using an aqueous solution of H2O2 (0.30  M, pH 3) with a maximum power density of 0.45 mW cm−2. The open‐circuit potential and maximum power density of the H2O2 fuel cell were further increased to 0.78 V and 1.2 mW cm−2, respectively, by operation under these conditions at pH 1. No catalytic activity of Co3[{CoIII(CN)6}2] and Co3[{FeIII(CN)6}2] towards H2O2 reduction suggests that the N‐bound Fe ions are active species for H2O2 reduction. H2O2 fuel cells that used Fe3[{MnIII(CN)6}2] and Fe3[{CrIII(CN)6}2] as the cathode exhibited lower performance compared with that using Fe3[{CoIII(CN)6}2] as a cathode, because ligand isomerization of Fe3[{MIII(CN)6}2] into (FeM2)[{FeII(CN)6}2] (M=Cr or Mn) occurred to form inactive FeC bonds under ambient conditions, whereas no ligand isomerization of Fe3[{CoIII(CN)6}2] occurred under the same reaction conditions. The importance of stable Fe2+N bonds was further indicated by the high performance of the H2O2 fuel cells with Fe3[{IrIII(CN)6}2] and Fe3[{RhIII(CN)6}2], which also contained stable Fe2+N bonds. The stable Fe2+N bonds in Fe3[{CoIII(CN)6}2], which lead to high activity for the electrocatalytic reduction of H2O2, allow Fe3[{CoIII(CN)6}2] to act as a superior cathode in one‐compartment H2O2 fuel cells.
A General Approach To Fabricate Fe3O4 Nanoparticles Decorated with Pd, Au, and Rh: Magnetically Recoverable and Reusable Catalysts for Suzuki CC Cross‐Coupling Reactions, Hydrogenation, and Sequential Reactions
Authors: Gonzàlez de Rivera Ferran , Angurell Inmaculada , Rossell Marta D. , Erni Rolf , Llorca Jordi , Divins Núria J. , Muller Guillermo , Seco Miquel , Rossell Oriol 
Published: July 2013

AbstractA facile strategy has been explored for loading noble metals onto the surface of ferrite nanoparticles with the assistance of phosphine‐functionalized linkers. Palladium loading is shown to occur with participation of both the phosphine function and the surface hydroxyl groups. Hybrid nanoparticles containing simultaneously Pd and Au (or Rh) are obtained by successive loading of metals. Similarly, ferrite nanoparticles decorated with Pd, Au, and Rh have also been formed by using the same strategy. The catalytic properties of the new nanoparticles are evidenced in processes such as reduction of 4‐nitrophenol or hydrogenation of styrene. Besides, the sequential process involving a cross‐coupling reaction followed by reduction of 1‐nitrobiphenyl has been successfully achieved by employing Pd/Au decorated nanoferrite particles.
Recent progress in non‐precious metal catalysts for PEM fuel cell applications
Authors: Higgins Drew C. , Chen Zhongwei 
Published: July 2013

AbstractThe development of non‐precious metal catalysts (NPMCs) that are practical for use at the cathode of polymer electrolyte membrane fuel cells (PEMFCs) would provide immense economic advantages, perpetuating the looming widespread commercialisation of these devices. NPMC materials with excellent activity towards the oxygen reduction, coupled with PEMFC performance approaching that of state‐of‐the‐art platinum catalysts brings this technology one step closer to practical application. Currently, the stability of these materials is still limited, and developing NPMC with excellent activity, performance and operational stability is the holy grail of PEMFC catalyst research. Fundamental knowledge available, along with recent progress made in this field of research will be the subject of this review paper.
Stability testing and shelf live prediction of a spouted bed dried phytopharmaceutical preparation from Maytenus ilicifolia
Authors: Souza Claudia R. F. , Ramos Danielle N. , Cortes‐Rojas Diego F. , Oliveira Wanderley P. 
Published: July 2013

AbstractIn this work the storage stability of a Maytenus ilicifolia phytopharmaceutical preparation produced by spouted bed drying was investigated. Powder samples of M. ilicifolia extracts were submitted to stress storage conditions at temperatures of 25, 34 and 45°C and relative humidities of 32.4% and 63.5%. The effect of the storage conditions on the physical and chemical properties of the product were evaluated through total polyphenols, tannin and catechin determination, moisture content, macroscopic changes in powder appearance and X‐ray difractograms. The results showed that high storage temperature and high relative humidity lead to increased degradation of the bioactive marker compounds. The shelf life of the spouted bed dried extracts was 276.2 days when the powder is stored at 25°C and 32.4% relative humidity.
Spouting of non‐spherical particles in conical‐cylindrical spouted bed
Authors: Shao Yingjuan , Zhong Wenqi , Chen Xi , Chen Yu , Jin Baosheng 
Published: July 2013

AbstractExperiments on the spouting of non‐spherical particles in a conical–cylindrical spouted bed, with an inside diameter of 200 mm and a conical base of 60°, were carried out. The minimum spouting status of six kinds of non‐spherical particles, the equi‐volume sphere diameter ranges from 1.9 to 6.2 mm and the sphericity ranges from 0.73 to 0.95, were tested and compared with two spherical particles. It was found that the changes of minimum spouting velocity with initial bed height and spout gas inlet diameter were similar to the spouting of spherical particles in conventional spouted beds, while decrease in particle sphericity would lead to an increase in the minimum spouting velocity. The tested minimum spouting velocities were well represented by the Mathur−Gishler equation of Ums, however a more satisfied prediction could be achieved for non‐spherical particles when replacing dp in Mathur−Gishler equation with a modified term φ−0.5dv.
A General and Highly Selective Method for the Asymmetric Synthesis of Trifluoromethyl‐Substituted α‐ and β‐Aminophosphonates
Authors: Wang Lijing , Shen Qilong , Lu Long 
Published: July 2013

AbstractA highly selective method for the asymmetric formation of trifluoromethyl‐substituted α‐ and β‐aminophosphonates was described. The reaction proceeded with high yields and good to excellent diastereoselectivity. The product can be easily converted into corresponding trifluoromethyl‐substituted aminophosphoric acids.
Synthesis and Biological Evaluation of Quinolinone Compounds as SARS CoV 3CLpro Inhibitors
Authors: Sun Yuanpei , Zhang Ning , Wang Jian , Guo Yu , Sun Bo , Liu Wei , Zhou Honggang , Yang Cheng 
Published: July 2013

AbstractSARS CoV 3CLpro is known to be a promising target for development of therapeutic agents against the severe acute respiratory syndrome (SARS). A quinolinone compound 1 was selected via virtual screening, and it was synthetized and tested for enzymatic inhibition in vitro. Compound 1 showed potent inhibitory activity (IC50=0.44 µmol/L) toward SARS CoV 3CLpro. Further work on a series of quinolinone derivatives resulted in the discovery of the most potent compound 23, inhibiting SARS CoV 3CLpro with an IC50 of 36.86 nmol/L. The structure‐activity relationships were also discussed.
Copper‐Mediated Trifluoromethylation of Terminal Alkynes by S‐(Trifluoromethyl)diarylsulfonium Salt
Authors: Wang Xiaoping , Lin Jinhong , Zhang Chengpan , Xiao Jichang , Zheng Xing 
Published: July 2013

AbstractThe copper‐mediated trifluoromethylation of terminal alkynes with S‐(trifluoromethyl)diarylsulfonium salt has been carefully investigated. The reactions proceeded smoothly to afford trifluoromethylated acetylenes in moderate to good yields. This approach is a convenient method to synthesize a variety of functional trifluoromethylated acetylenes.
Copper(I)‐Catalyzed Intramolecular Direct C‐Arylation of Azoles with Aryl Bromides
Authors: Huang Yuan , Chen Wei , Zhao Dan , Chen Chen , Yin Huiqing , Zheng Likang , Jin Ming , Han Shiqing 
Published: July 2013

AbstractA concise route to access 5H‐imidazo[2,1‐a]isoindole heterofused compounds by copper(I)‐catalyzed intramolecular coupling of non‐activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10‐phenanthroline as ligand, and K3PO4 as base, the reactions of 1‐(2‐bromobenzyl)‐1H‐imidazoles in DMF/o‐xylene (1:1, V:V) at 145°C afford the corresponding substituted 5H‐imidazo[2,1‐a]isoindoles in high yields via intramolecular C‐arylation.
On Water: Free Catalysis Approach for the Synthesis of Nitrones from Hydroxamic Acids and Dimethy/Diethyl Acetylenedicarboxylate
Authors: Li Jian , He Yongqin , Ren Xiaoyu , Shi Xiaokang , Yang Sizhuo , Gao Xiai , Huang Guosheng 
Published: July 2013

AbstractBenzohydroxamic acid reacts with dimethyl acetylenedicarboxylate in the presence of 10 mol% NaOAc to generate (E)‐N‐(1,4‐dimethoxy‐1,4‐dioxobutan‐2‐ylidene)‐1‐phenylcarboxamide oxide in good‐to‐excellent yield in water at room temperature for 2 h, which supplies a simple, efficient and environmentally friendly method to synthesize a wide range of nitrones. The benefits of this strategy not only conform to the requirment of green chemisty, but also possess atom economy.
Efficient Synthesis of Spiro[furan‐3,3′‐indoline] Derivatives via Reactions of Pyridinium Salts with Isatinylidene Acetoacetates
Authors: Liu Zhenming , Fang Jun , Yan Chaoguo 
Published: July 2013

AbstractAn efficient synthetic procedure for the functionalized spiro[furan‐3,3′‐indoline] derivatives was successfully developed by domino reactions of N‐phenacylpyridinium bromides or N‐ethoxycarbonylmethylenepyridinium bromide with isatinylidene acetoacetate in the presence of triethylamine in ethanol at room temperature. The mechanism included sequential Michael addition of the in situ generated pyridinium ylide and intramolecular substitution of enolate.
Direct Introduction of Ethoxycarbonyldifluoromethyl‐Group to Heteroarenes with Ethyl Bromodifluoroacetate via Visible‐Light Photocatalysis
Authors: Lin Qingyu , Chu Lingling , Qing Feng‐Ling 
Published: July 2013

AbstractA mild and versatile approach for the direct introduction of ethoxycarbonyldifluoromethyl‐group to heteroarenes via visible‐light photocatalysis has been developed. The new photoredox protocol has enabled the difluoromethylenation of heteroarenes containing a wide range of common functional groups under mild conditions.
Biodegradation of a Paper and Pulp Effluent by Rhodococcus sp. NCIM 2891 and Its Toxicity Assessments
Authors: Nadaf Naiem H. , Ghosh Jai S. 
Published: July 2013

AbstractThis investigation is aimed to reduce the pollution and ecotoxicological impact of the paper and pulp industry effluent by Rhodococcus sp. NCIM 2891. It was observed that the Rhodococcus sp. NCIM 2891, when grown in the presence of the effluent, there was a significant decrease in levels of biological oxygen demand (81.25%) 30 mg/L and chemical oxygen demand (53.23%) 363 mg/L as compared to untreated samples with 160 and 776 mg/L, respectively. Reduction in total dissolved solids could be observed (81%) along with reduction in heavy metal concentration. Further analysis of the degraded effluent compounds was carried out by atomic absorption spectroscopy. The eco‐compatibility of the effluent and degraded product was checked in terms of their toxicity on Allium cepa, Acantopsis choirorhynchus, and different microorganisms. The degraded products obtained after biodegradation are found to be eco‐compatible and non‐toxic.
Glioblastoma survival in the United States improved after Food and Drug Administration approval of bevacizumab: A population‐based analysis
Authors: Johnson Derek R. , Leeper Heather E. , Uhm Joon H. 
Published: July 2013

BACKGROUNDBevacizumab received US Food and Drug Administration approval for use in recurrent glioblastoma based on promising radiographic response data, but without clear evidence that it prolongs survival. A population‐based analysis was conducted to determine whether bevacizumab approval was associated with improved glioblastoma survival in the United States.METHODSSurveillance, Epidemiology, and End Results (SEER) Program data were used to compare survival of glioblastoma patients who died in 2006, 2008 (both prior to approval of bevacizumab), and 2010 (after approval of bevacizumab).RESULTSThe SEER database contained 1715 patients with glioblastoma who died in 2006, 1924 who died in 2008, and 1968 who died in 2010 who met study inclusion criteria. Median survival was 8 months for those who died in 2006, 7 months in 2008, and 9 months in 2010. The difference in survival between 2008 (pre‐bevacizumab) and 2010 (post‐bevacizumab) was highly significant. This difference is unlikely to be due to improvements in supportive care in this short interval, because there was no significant difference (P = .4440) between patients who died in 2006 versus those who died in 2008. Between 2008 and 2010, a statistically significant improvement in survival was seen in all age groups except those patients aged 18 to 39 years.CONCLUSIONSPatients who died of glioblastoma in 2010 had lived with disease significantly longer than patients who died in 2008. The most likely explanation for this change is the approval and use of bevacizumab for progressive glioblastoma, indicating that at a population level, treatment strategies involving bevacizumab prolong survival. Cancer 2013;119:3489–3495.. © 2013 American Cancer Society.
Numerical quadrature and operator splitting in finite element methods for cardiac electrophysiology
Authors: Krishnamoorthi Shankarjee , Sarkar Mainak , Klug William S. 
Published: July 2013

SUMMARYWe study the numerical accuracy and computational efficiency of alternative formulations of the finite element solution procedure for the monodomain equations of cardiac electrophysiology, focusing on the interaction of spatial quadrature implementations with operator splitting and examining both nodal and Gauss quadrature methods and implementations that mix nodal storage of state variables with Gauss quadrature. We evaluate the performance of all possible combinations of ‘lumped’ approximations of consistent capacitance and mass matrices. Most generally, we find that quadrature schemes and lumped approximations that produce decoupled nodal ionic equations allow for the greatest computational efficiency, this being afforded through the use of asynchronous adaptive time‐stepping of the ionic state variable ODEs. We identify two lumped approximation schemes that exhibit superior accuracy, rivaling that of the most expensive variationally consistent implementations. Finally, we illustrate some of the physiological consequences of discretization error in electrophysiological simulation relevant to cardiac arrhythmia and fibrillation. These results suggest caution with the use of semi‐automated free‐form tetrahedral and hexahedral meshing algorithms available in most commercially available meshing software, which produce nonuniform meshes having a large distribution of element sizes. Copyright © 2013 John Wiley & Sons, Ltd.
Modeling the dispersion in electromechanically coupled myocardium
Authors: Eriksson Thomas S. E. , Prassl Anton J. , Plank Gernot , Holzapfel Gerhard A. 
Published: July 2013

SUMMARYWe present an approach to model the dispersion of fiber and sheet orientations in the myocardium. By utilizing structure parameters, an existing orthotropic and invariant‐based constitutive model developed to describe the passive behavior of the myocardium is augmented. Two dispersion parameters are fitted to experimentally observed angular dispersion data of the myocardial tissue. Computations are performed on a unit myocardium tissue cube and on a slice of the left ventricle indicating that the dispersion parameter has an effect on the myocardial deformation and stress development. The use of fiber dispersions relating to a pathological myocardium had a rather big effect. The final example represents an ellipsoidal model of the left ventricle indicating the influence of fiber and sheet dispersions upon contraction over a cardiac cycle. Although only a minor shift in the pressure–volume (PV) loops between the cases with no dispersions and with fiber and sheet dispersions for a healthy myocardium was observed, a remarkably different behavior is obtained with a fiber dispersion relating to a diseased myocardium. In future simulations, this dispersion model for myocardial tissue may advantageously be used together with models of, for example, growth and remodeling of various cardiac diseases. Copyright © 2013 John Wiley & Sons, Ltd.
Influence of the Metal Ion on the Two‐Photon Absorption Properties of Lanthanide Complexes Including Near‐IR Emitters
Authors: Bourdolle Adrien , Allali Mustapha , D'Aléo Anthony , Baldeck Patrice L. , Kamada Kenji , Williams J. A. Gareth , Le Bozec Hubert , Andraud Chantal , Maury Olivier 
Published: July 2013

AbstractThe synthesis of tris(2‐thenoyltrifluoroacetonate)lanthanide(III) complexes featuring a diethylaminostyryl‐2,2′‐bipyridine coligand was achieved for lanthanum; the near‐infrared (NIR) emitters neodymium, erbium, and ytterbium; and the transition‐metal yttrium. The photophysical properties were thoroughly studied, and it was demonstrated that the conjugated bipyridine ligand acts as a good antenna for the sensitization of the NIR emitters. The two‐photon absorption (TPA) properties of all five complexes were investigated by using both two‐photon excited fluorescence and the Z‐scan method. We demonstrate that the nature of the rare earth ion has almost no influence on the TPA properties centered on the conjugated bipyridyl ligand. Finally, we show that YbIII is sensitized by a two‐photon antenna effect, and that NdIII is mostly sensitized by a one‐photon process involving direct excitation of forbidden f–f transitions.
Superhydrophobic Mesoporous Graphene for Separation and Absorption
Authors: Fan Zong‐Liang , Qin Xiao‐Juan , Sun Han‐Xue , Zhu Zhao‐Qi , Pei Chun‐juan , Liang Wei‐Dong , Bao Xue‐Mei , An Jin , La Pei‐Qing , Li An , Deng Wei‐Qiao 
Published: July 2013

AbstractMesoporous graphene with a surface area of 306 m2 g−1 was synthesized by employing CaCO3 microspheres as hard templates. By surface modification with polydimethylsiloxane (PDMS) through chemical vapor deposition, the wettability of as‐treated mesoporous graphene can be tailored to be superhydrophobic to water while superoleophilic to oils. The deposition of the low‐surface‐energy silicon‐coating originated from PDMS pyrolysis on porous graphene was confirmed by X‐ray photoelectron spectroscopy. As a result of its porous structures and excellent surface superhydrophobicity, the PDMS‐treated mesoporous graphene exhibits good selectivity, excellent recyclability, and good absorption performance (up to 66 g g−1) for a wide range of oils and organic solvents. Thus, leading to potential use in a variety of applications such as water treatment and purification as well as cleanup of oil spills.