bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture
Authors: Barfield Dominic M , Gibson Andrew D , Lipscomb Vicky J 
Published: June 2015

Case summary A cat with a chronic diaphragmatic rupture presented with neurological signs, including twitching and focal seizures. Blood ammonia level was markedly elevated and therefore neurological signs were thought to be related to hepatic encephalopathy. Exploratory laparotomy revealed that the left lateral and medial liver lobes were herniated into the thorax and multiple acquired portosystemic shunts (MAPSS) were present. The hernia was reduced and the diaphragm repaired. Neurological signs gradually resolved following surgery and 1 year postoperatively the cat was clinically normal, was not on any medication and had no evidence of hepatic dysfunction. Relevance and novel information This is the first report of a chronic diaphragmatic rupture leading to MAPSS in a cat.
Evaluation of thromboelastography in two factor XII-deficient cats
Authors: Blois Shauna L , Holowaychuk Marie K , Wood R Darren 
Published: June 2015

Case summary The current report describes thromboelastography (TEG) findings in two cats with factor XII (FXII) deficiency. The first cat was diagnosed with bilateral perinephric pseudocysts; hemostatic testing was performed prior to performing renal aspirates. The second cat was healthy; hemostatic testing was performed prior to inclusion into a research project. Both cats had markedly prolonged partial thromboplastin times and hypocoagulable TEG tracings when samples were activated with kaolin. However, when tissue factor (TF) was used to activate the sample, both cats had normal-to-hypercoagulable TEG tracings. The cats each had a subnormal FXII level. Relevance and novel information TEG is becoming widely used to investigate hemostasis in veterinary patients, and TEG results in cats with FXII deficiency have not been previously reported. FXII deficiency is the most common hereditary hemostatic defect in cats. While FXII deficiency does not lead to in vivo hemorrhagic tendencies, it can lead to marked prolongation in activated partial thromboplastin and activated clotting times, and cannot be differentiated from true hemorrhagic diatheses without measuring individual factor activity. With the increased use of TEG to evaluate hemostasis in veterinary patients, it is important to recognize the effects of FXII deficiency on this testing modality. The finding of a hypocoagulable kaolin-activated TEG tracing and a concurrent normal TF-activated TEG tracing in samples should prompt clinicians to consider ruling out FXII deficiency.
Is Scheduled Intravenous Acetaminophen Effective in the Pain Management Protocol of Geriatric Hip Fractures?
Authors: Bollinger Alexander J. , Butler Paul D. , Nies Matthew S. , Sietsema Debra L. , Jones Clifford B. , Endres Terrence J. 
Published: June 2015

Background: Hip fractures have significant effects on the geriatric population and the health care system. Prior studies have demonstrated both the safety of intravenous (IV) acetaminophen and its efficacy in decreasing perioperative narcotic consumption. The purpose of this study is to evaluate the effect of scheduled IV acetaminophen for perioperative pain control on length of hospital stay, pain level, narcotic use, rate of missed physical therapy (PT) sessions, adverse effects, and discharge disposition in geriatric patients with hip fractures. Methods: A retrospective review was performed of all patients 65 years and older admitted to a level I trauma center, who received operative treatment for a hip fracture over a 2-year period. Demographic data, in-hospital variables, and outcome measures were analyzed. Three hundred thirty-six consecutive fractures in 332 patients met inclusion criteria. These patients were divided into 2 cohorts. Group 1 (169 fractures) consisted of patients treated before the initiation of a standardized IV acetaminophen perioperative pain control protocol, and group 2 (167 fractures) consisted of those treated after the protocol was initiated. Results: Group 2 had a statistically significant shorter mean length of hospital stay (4.4 vs 3.8 days), lower mean pain score (4.2 vs 2.8), lower mean narcotic usage (41.3 vs 28.3 mg), lower rate of PT sessions missed (21.8% vs 10.4%), and higher likelihood of discharge home (7% vs 19%; P ≤ .001). Use of IV acetaminophen was also consistently and independently predictive of the same variables ( P < .01). Conclusion: The utilization of scheduled IV acetaminophen as part of a standardized pain management protocol for geriatric hip fractures resulted in shortened length of hospital stay, decreased pain levels and narcotic use, fewer missed PT sessions, and higher rate of discharge to home. Level of Evidence: Therapeutic level III.
The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice
Authors: Cui Shuaiying , Lim Kim-Chew , Shi Lihong , Lee Mary , Jearawiriyapaisarn Natee , Myers Greggory , Campbell Andrew , Harro David , Iwase Shigeki , Trievel Raymond C. , Rivers Angela , DeSimone Joseph , Lavelle Donald , Saunthararajah Yogen , Engel James Douglas 
Published: June 2015

Key Points
RN-1 treatment of SCD mice results in increased human fetal γ-globin induction and fetal hemoglobin synthesis. RN-1 treatment of SCD mice significantly reduces sickling, hemolysis, and tissue injury with no obvious adverse side effects.
Altered effector functions of NK cells in chronic hepatitis C are associated with IFNL3 polymorphism
Authors: Rogalska-Taranta Magdalena , Markova Antoaneta A , Taranta Andrzej , Lunemann Sebastian , Schlaphoff Verena , Flisiak Robert , Manns Michael P , Cornberg Markus , Kraft Anke R M , Wedemeyer Heiner 
Published: June 2015

Abstract
Interferon α-mediated effector functions of NK cells may contribute to the control of HCV replication and the pathogenesis of liver disease. The single-nucleotide polymorphism rs12979860 near IFNL3 (previously known as IL28B) is important in response to IFN-α treatment and in spontaneous resolution of acute hepatitis C. The role of the IFNL3 polymorphism in NK cell function is unclear. Thus, we investigated the role of IFNL3 polymorphism in type I IFN-dependent regulation of NK cell functions in patients with cHC and healthy control subjects. We demonstrated a marked polarization of NK cells toward cytotoxicity in response to IFN-α stimulation in patients with hepatitis C. That TRAIL up-regulation was present, particularly in patients with the IFNL3-TT allele, was supported by a shift in the pSTAT-1:pSTAT-4 ratios toward pSTAT-1. In patients bearing the IFNL3-TT allele, NK cell effector function correlated with liver disease activity. In contrast, higher cytokine production of NK cells was observed in healthy individuals with the IFNL3-CC genotype, which may support spontaneous HCV clearance in acute infection. Overall, these findings show that the role of NK cells may differ in chronic infection vs. early antiviral defense and that the IFNL3 genotype differentially influences NK cell function.
The future of murine sepsis and trauma research models
Authors: Efron Philip A , Mohr Alicia M , Moore Frederick A , Moldawer Lyle L 
Published: June 2015

Abstract
Recent comparisons of the murine and human transcriptome in health and disease have called into question the appropriateness of the use of murine models for human sepsis and trauma research. More specifically, researchers have debated the suitability of mouse models of severe inflammation that is intended for eventual translation to human patients. This mini-review outlines this recent research, as well as specifically defines the arguments for and against murine models of sepsis and trauma research based on these transcriptional studies. In addition, we review newer advancements in murine models of infection and injury and define what we envision as an evolving but viable future for murine studies of sepsis and trauma.
Schleicher: Open data are available in the SEG Wiki
Authors: Farley Isaac 
Published: June 2015

This SEG Wiki interview, the fourth in the series, features Karl Schleicher, senior research fellow, Bureau of Economic Geology at the University of Texas at Austin. Schleicher joins Isaac Farley, SEG digital publications manager, to discuss open data in the SEG Wiki. In August, look for the final wiki interview of 2015 with John W. Stockwell Jr., 2014 SEG Wiki Champion. [Figure: see text]
Accurate Prediction and Validation of Response to Endocrine Therapy in Breast Cancer
Authors: Turnbull Arran K. , Arthur Laura M. , Renshaw Lorna , Larionov Alexey A. , Kay Charlene , Dunbier Anita K. , Thomas Jeremy S. , Dowsett Mitch , Sims Andrew H. , Dixon J. Michael 
Published: June 2015

PurposeAromatase inhibitors (AIs) have an established role in the treatment of breast cancer. Response rates are only 50% to 70% in the neoadjuvant setting and lower in advanced disease. Accurate biomarkers are urgently needed to predict response in these settings and to determine which individuals will benefit from adjuvant AI therapy.Patients and MethodsPretreatment and on-treatment (after 2 weeks and 3 months) biopsies were obtained from 89 postmenopausal women who had estrogen receptor–alpha positive breast cancer and were receiving neoadjuvant letrozole for transcript profiling. Dynamic clinical response was assessed with use of three-dimensional ultrasound measurements.ResultsThe molecular response to letrozole was characterized and a four-gene classifier of clinical response was established (accuracy of 96%) on the basis of the level of two genes before treatment (one gene [IL6ST] was associated with immune signaling, and the other [NGFRAP1] was associated with apoptosis) and the level of two proliferation genes (ASPM, MCM4) after 2 weeks of therapy. The four-gene signature was found to be 91% accurate in a blinded, completely independent validation data set of patients treated with anastrozole. Matched 2-week on-treatment biopsies were associated with improved predictive power as compared with pretreatment biopsies alone. This signature also significantly predicted recurrence-free survival (P = .029) and breast cancer –specific survival (P = .009). We demonstrate that the test can also be performed with use of quantitative polymerase chain reaction or immunohistochemistry.ConclusionA four-gene predictive model of clinical response to AIs by 2 weeks has been generated and validated. Deregulated immune and apoptotic responses before treatment and cell proliferation that is not reduced 2 weeks after initiation of treatment are functional characteristics of breast tumors that do not respond to AIs.
Mental Health Services for Parents Who Lost a Child to Cancer: If We Build Them, Will They Come?
Authors: Lichtenthal Wendy G. , Corner Geoffrey W. , Sweeney Corinne R. , Wiener Lori , Roberts Kailey E. , Baser Raymond E. , Li Yuelin , Breitbart William , Kissane David W. , Prigerson Holly G. 
Published: June 2015

Purpose To examine bereavement mental health service use, barriers to use, and factors associated with use in parents bereaved by cancer. Patients and Methods A multicenter, cross-sectional study of 120 parents bereaved by cancer between 6 months and 6 years after their loss was performed. Parents completed self-report assessments of mental health service use and barriers, prolonged grief, depression, anxiety, attachment styles, and sense of meaning by phone, in person, or on their own. Results Forty-one percent of bereaved parents were currently using mental health services (talk therapy, psychotropic medication, and/or a support group), most commonly within the first 2 years after their loss. Talk therapy was the most frequently used service, although 36% of parents who discontinued therapy did so because it was not helpful. Forty percent of parents who wanted bereavement support reported they were not receiving services. The most common barriers to service use were that it was too painful to speak about the loss (64%) and too difficult to find help (60%). Factors associated with current mental health service use included more recent loss, prior mental health service use, subclinical/increased depression, insecure attachment styles, and a decreased sense of meaning. Minority parents were more likely to have unmet needs than nonminority parents. Conclusion Parents appear to need, want, and often access bereavement mental health services, which could be offered in oncology settings. However, barriers to service use must be addressed, particularly for those with more debilitating grief symptoms and for minorities. High treatment dropout rates suggest the importance of improving retention, training providers, and developing effective grief interventions.
Transgression: Normativity’s Self-Inversion
Authors: Kirby Vicki 
Published: June 2015

Attempting to explain the how, what, and why of normativity has exercised the attentions of social analysts for centuries, remaining an enduring puzzle in sociology since its disciplinary inception. A nest of related riddles attend the subjectivation of the individual, or how the social gets under our skin. How does an outside (social norms, grids of intelligibility, and behavioral compliance) also articulate the inside (personal belief and conscience, and even biological symptomatologies)? Given this intricate involvement between the inside and the outside, an involvement whose causal origin cannot be determined, should the conscious strategies of antinormativity be understood as interventions that hail from outside these norms or as expressions of power’s internal and perverse machinations? If norms are considered the genetics of power that inform all of social life (without necessarily dictating it), then the peculiar identity and ubiquity of a norm is neither restricted nor prohibited. In sum, what is normal about a norm?
This essay explores power’s intransitivity, its “self-possession,” by interrogating the way that cultural analysis routinely assumes that the workings of power rest on a break with nature, a break that explains human exceptionalism as an unnatural perversion of nature’s previous conventions and prescriptions. By way of Georges Canguilhem, the argument dilates on the implications of this foundational assumption, itself a form of antinormativity, by shifting its frame of reference to that of life itself.
Apoptotic cell-derived membrane microparticles and IFN-α induce an inflammatory immune response
Authors: Niessen A. , Heyder P. , Krienke S. , Blank N. , Tykocinski L.-O. , Lorenz H.-M. , Schiller M. 
Published: June 2015

The dysregulation in clearance of apoptotic material is considered a major pathogenetic factor for the emergence of autoimmune diseases. Apoptotic cell-derived membrane microparticles (AdMPs), released from the cell surface during apoptosis, have been implicated in the pathogenesis of autoimmunity. Also of importance are cytokines such as interferon-alpha (IFN-α), known as a major player in patients with systemic lupus erythematosus (SLE). This study investigates the combined effect of AdMPs and IFN-α on professional phagocytes.
In the presence of IFN-α, phagocytosis of AdMPs by human monocytes was significantly increased in a dose-dependent manner. The combination of AdMPs and raised IFN-α concentrations resulted in an increase in the secretion of pro-inflammatory cytokines and an upregulation of surface molecule expression involved in antigen uptake. Also, macrophage polarisation was shifted towards a more inflammatory type of cell. The synergism between IFN-α and AdMPs seems to be mediated by an upregulation of phosphorylated STAT1.
Our results indicate that IFN-α together with AdMPs amplify the initiation and maintenance of inflammation. Especially in disorders with a defective clearance of apoptotic material, this mechanism might play a crucial role.
Standard Values of Coefficients When Forming the Rating of the Financial and Economic Condition of the Enterprise
Authors: Графова  , Grafova Galina , Аврашков  , Avrashkov Lyev , Шахватова  , Shakhvatova S. 
Published: June 2015

Criteria and indicators for more perfect methodical approaches to coefficients’ standard values definition and
formation of the rating assessment related to an enterprise’s financial and economic condition have been presented in this
paper as well as an analysis of these criteria and indicators.
Zwyczaj picia kawy i herbaty odzwierciedlony w polskim słownictwie i frazeologii
Authors: Piela Agnieszka 
Published: June 2015

The habit of drinking coffee and tea reflected in Polish lexicon and phraseology
The paper shows that it is not just the habit of drinking coffee and tea that has changed over the centuries, but also the lexicon of the related semantic circle. Polish preserves the basic vocabulary pertaining to the culture of coffee and tea drinking; some units have undergone a semantic metamorphosis and remained in the language, others did not withstand the test of time and faded into oblivion. It should be emphasized that the analysed lexical layer is constantly evolving, as is proven by new names for our stimulants, such as lura ‘weak tea’, słomka ‘weak tea’, pistoletówka ‘black coffee’, szatan ‘strong black coffee’ etc.
Etymologia a językowo-kulturowy obraz jałowca i kaliny
Authors: Kielak Olga 
Published: June 2015

Etymology and the cultural-linguistic image of jałowiec ‘juniper’ and kalina ‘viburnum’
The paper tries to answer the question about the onomastic base of the names for ‘juniper’ and ‘viburnum’, i.e. which of their features or what image of these plants has been preserved in their names. The author tests whether the features captured in literary and dialectal Polish names for these shrubs are confirmed by folk texts, popular narratives and beliefs. Hypotheses put forward by etymologists are verified and confronted with the linguistic material which the author used to reconstruct the linguistic-cultural image of juniper and viburnum in colloquial and folk Polish. The paper is a yet another voice in the discussion about the suitability of ethnolinguistic research for the study of etymology, and the usefulness of etymology for ethnolinguists.
Rosyjskie липа, липовый i polskie lipa, lipny
Authors: Skarżyński Mirosław 
Published: June 2015

Russian липа, липовый ‘counterfeit’ and Polish lipa, lipny ‘false’
The paper debates the interpretation of the etymology of Polish lipa ‘something untrue’ given by A. Bańkowski in his Etymologiczny słownik języka polskiego ‘Etymological dictionary of Polish’. Based on Russian and Polish lexicographical data, the author describes the rise of the Russian noun липа as a derivative from the older adjective липовый ‘false, counterfeit’ in the thieves’ slang of the 19th century, and subsequently its path into colloquial Russian. The word lipa was borrowed into Polish in the second half of the 19th century in the meaning ‘fake passport, document’, also ‘something counterfeit’. It first appeared in the slang of Polish thieves, then penetrated into the dialect of Warsaw, and eventually into colloquial Polish where it is used as a polysemous word, and became the base for the also polysemous derivative adjective lipny.
Archaizmy leksykalne w gwarach góralskich (na przykładzie wybranego słownictwa rodzinnego)
Authors: Gotówka Agnieszka 
Published: June 2015

Lexical archaisms in the dialects of Polish highlanders (using the example of selected native vocabulary)
The material for our analysis of archaisms came from peripheral dialects of Polish highlanders. These dialects are some of the varieties of Polish which have been quite well preserved. The term ‘highlanders’ dialect’ is understood broadly, to be any dialect of Polish highlanders from Podhale, Spiš, Orava, the Ƶywiec area, and Cieszyn Silesia. The lexical individuality of these regions is a result of different historical and geographical factors. My reasearch focused on vocabulary related to family, and in particular to the ways of referring to important figures in familial relations. Highlanders’ families did and still do traditionally hierarchize the roles of family members with regard to their age and position. The discussed lexemes have been long archived in literary Polish; they are now entirely passive in their primary meanings, but they continue to thrive in dialects.
Antroponimia Żydów w przestrzeni nazewniczej międzywojennej Bydgoszczy – system imion
Authors: Jaracz Małgorzata 
Published: June 2015

Jewish anthroponymy in the naming space of interwar Bydgoszcz – the system of given names
The article discusses the problem of given names of Jews who lived in Bydgoszcz between 1920 and 1939. The diaspora counted at most two thousand (about 1,5% of the total population) and, apart from Poznań, it was the largest concentration of Jews in the Poznań voivodeship. The data was extracted from a list of contribution payers of the Jewish religious community from 1939. The current paper continues the research started in my previous article (Jaracz 2007) (‘Last names of Bydgoszcz Jews in the context of the Polish anthroponymic system’).
O sposobach tworzenia nazw miejscowości w świetle etymologii ludowej
Authors: Rogowska-Cybulska Ewa 
Published: June 2015

On creation of place names in the light of folk etymology
The paper discusses the ways in which Polish place names were created, in the light of their folk etymologies. The author uses the example of selected morphological reinterpretations of place names from various regions of Poland. By comparing folk-etymologized place names, and the words and expression that they indicate as bases for derivation, the paper shows that, in fact, folk etymology divides Polish toponyms into similar structural categories as scientific etymology: the primary, the secondary, and the compound. Very few re-etymologized place names do not fit into any of these types. In details, however, pseudoetymologies differ from the results of onomastic research with regard to the methods of creation of place names. Among other differences, the former tend to prefer certain structural types, especially compounds, and display a greater degree of tolerance for phonetic differences.
Spontaniczne nabywanie umiejętności wymowy wybranych elementów segmentalnych w języku hiszpańskim przez rodowitych użytkowników języka polskiego – studium przypadku
Authors: Sobański Tomasz 
Published: June 2015

Spontaneous acquisition of pronunciation of selected segmental elements in Spanish, by native speakers of Polish. A case study
A contrastive analysis of the phonology and phonetics of the native and a foreign tongue cannot foresee all pronunciation errors in the foreign language; their character needs to be established experimentally. The goal of this paper is to determine whether subjects can spontaneously acquire the pronunciation of selected sounds of Spanish, and whether the form of the stimulus (written vs. oral) influences the phonetic correctness of the result. The experiment was conducted on two students. The corpus was made up by an oral statement (reading of a series of sentences), and free answers to oral questions. The results show that correct pronunciation occurs when sounds are identical in both languages, and to a certain degree, when L2 sounds are absent from L1. Errors arise when sounds are similar but not identical in L1 and L2. The correctness of realization increases during free speech, and the increase is independent from the skill level of the subject.