bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of α‐Tetrasubstituted Triazoles by Copper‐Catalyzed Silyl Deprotection/Azide Cycloaddition.
Authors: Palchak Zachary L. , Nguyen Paula T. , Larsen Catharine H. 
Published: October 2015

AbstractThe applied starting material is prepared in one step by means of copper‐catalyzed ketone‐amine‐alkyne (KA2) coupling.
ChemInform Abstract: [3 + 2] Cycloadditions of Azides with Arynes via Photolysis of Phthaloyl Peroxide Derivatives.
Authors: Chang Denghu , Zhu Dan , Shi Lei 
Published: October 2015

AbstractCycloaddition of photo‐generated benzynes with azides affords benzotriazoles in moderate to good yields at room temperature.
ChemInform Abstract: Visible Light Induced, Catalyst Free, Convenient Synthesis of Chromene Nucleus and Its Derivatives Using Water—Ethanol Mixture as a Solvent.
Authors: Yadav Snehlata , Srivastava Madhulika , Rai Pratibha , Singh Jaya , Prasad Tiwari Kamla , Singh Jagdamba 
Published: October 2015

AbstractA highly efficient, green, eco‐friendly, one pot protocol is presented for the synthesis of 2‐imino‐2H‐chromene‐3‐carbonitrile (III), 2‐aminochromene (IV), and chromeno(2,3‐b)pyridines (V).
ChemInform Abstract: Coproduct Promoted Povarov Reaction: Synthesis of Substituted Quinolines from Methyl Ketones, Arylamines, and α‐Ketoesters.
Authors: Gao Qinghe , Liu Shan , Wu Xia , Zhang Jingjing , Wu Anxin 
Published: October 2015

AbstractThe reaction utilizes catalytic HI co‐product as a promoter.
ChemInform Abstract: Synthesis and Fluorescence Properties of 4‐Diarylmethylene Analogues of the Green Fluorescent Protein Chromophore.
Authors: Miyashita Kazuyuki , et al.  
Published: October 2015

AbstractThe novel condensation reaction between imidates or thioimidates with N‐(diarylmethylene)glycinates affords imidazolinone derivatives with interesting fluorescence properties.
ChemInform Abstract: β‐Cyclodextrin‐propyl Sulfonic Acid: A New and Eco‐Friendly Catalyst for One‐Pot Multi‐Component Synthesis of 3,4‐Dihydropyrimidones via Biginelli Reaction.
Authors: Gong Kai , Wang Hualan , Wang Shuxin , Ren Xiaoxue 
Published: October 2015

AbstractThe title reaction starts from aromatic aldehydes, 1,3‐dicarbonyl compounds and urea or thiourea.
ChemInform Abstract: Direct Synthesis of 5‐Aryl Barbituric Acids by Rhodium(II)‐Catalyzed Reactions of Arenes with Diazo Compounds.
Authors: Best Daniel , Burns David J. , Lam Hon Wai 
Published: October 2015

AbstractThe coupling of arenes with 5‐diazobarbituric acids in the presence of a Rh(II)‐catalyst provides medicinally important compounds in a direct fashion which is more suited to drug discovery than existing technologies.
ChemInform Abstract: Expedient Synthesis of 6‐Acylindolo[1,2‐a]quinoxalines.
Authors: Trawczynski Adam , Telega Magdalena , Wrobel Zbigniew 
Published: October 2015

AbstractOne unsubstituted CH3‐group in the diketone is necessary for the condensation: hepta‐3,5‐dione does not react.
ChemInform Abstract: Ligand‐Controlled Regiodivergent Cu‐Catalyzed Aminoboration of Unactivated Terminal Alkenes.
Authors: Sakae Ryosuke , Hirano Koji , Miura Masahiro 
Published: October 2015

AbstractFunctionalized alkylamines are obtained by reaction of unactivated terminal alkenes with diboron reagents and hydroxylamines.
ChemInform Abstract: Transformation of Azulenes to Bicyclic [4]Dendralene and Heptafulvene Derivatives via Photochemical Cycloaddition of Dialkylsilylene.
Authors: Kosai Tomoyuki , Ishida Shintaro , Iwamoto Takeaki 
Published: October 2015

AbstractRegioselective cycloaddition of dialkylsilylene (II) upon irradiation at 440 nm converts azulene and guaiazulene to bicyclic [4]dendralene (III) and heptafulvene (V) derivatives, respectively.
ChemInform Abstract: Photoinduced Reductive Perfluoroalkylation of Phosphine Oxides: Synthesis of P‐Perfluoroalkylated Phosphines Using TMDPO and Perfluoroalkyl Iodides.
Authors: Sato Yuki , Kawaguchi Shin‐ichi , Ogawa Akiya 
Published: October 2015

AbstractA photoinduced reaction of (diphenyl(2,4,6‐trimethylbenzoyl)‐phosphine oxide) and perfluoroalkyl iodides successfully affords P‐(perfluoroalkyl)diphenylphosphines as promising ligands for recyclable catalysts.
ChemInform Abstract: Copper‐Mediated Synthesis of Aryldifluoromethylphosphonates: A Sandmeyer Approach.
Authors: Bayle Alexandre , Cocaud Chloe , Nicolas Cyril , Martin Olivier R. , Poisson Thomas , Pannecoucke Xavier 
Published: October 2015

AbstractThe CuCF2‐PO(O‐Et)2 species, generated in situ under optimized mild conditions, reacts with various aryl diazonium salts to produce the synthetically and pharmaceutically important target compounds bearing various functionalities at the phenyl moiety.
ChemInform Abstract: Antiinflammatory Activity of Pyrrolizidine Alkaloids from the Leaves of Madhuca pasquieri (Dubard)
Authors: Hoang Le Son , Tran Manh Hung , Lee Joo Sang , To Dao Cuong , Nguyen Van Thu , Kim Jeong Ah , Lee Jeong Hyung , Woo Mi Hee , Min Byung Sun 
Published: October 2015

Abstractisolation and structure elucidation of madhumidine A (I)
ChemInform Abstract: Fistulains A and B, New Bischromones from the Bark of Cassia fistula, and Their Activities.
Authors: Zhou Min , Zhou Kun , Gao Xue‐Mei , Jiang Zhi‐Yong , Lv Jun‐Jiang , Liu Zhi‐Hua , Yang Guang‐Yu , Miao Ming‐Ming , Che Chun‐Tao , Hu Qiu‐Fen 
Published: October 2015

AbstractFistulain A (I) displays anti‐TMV (tobacco mosaic virus) activity, and both Fistulains show weak cytotoxicity.
Fast Screening of Whole Blood Samples and Pharmaceutical Compounds for Enantiorecognition of Free L‐T3, L‐T4, and D‐T4
Authors: Mitrofan Grigorina , Stefan‐van Staden Raluca‐Ioana , Comnea‐Stancu Ionela Raluca , van Staden Jacobus Frederick , Bazylak Grzegorz , Kapnissi‐Christodoulou Constantina P. , Aboul‐Enein Hassan Y. 
Published: October 2015

AbstractA fast screening method of whole blood was proposed for enantiorecognition of free L‐T3, L‐T4, and D‐T4. Stochastic microsensors based on four inulins (IN, IQ, TEX, and HD) immobilized on diamond paste (DP) were used for recognition of free L‐T3, L‐T4, and D‐T4. For the enantiorecognition of free L‐T4 and D‐T4 in whole blood and pharmaceutical samples, the best microsensor was the one based on TEX/DP (wide linear concentration ranges, and low limits of quantification). The best limit of detection for the assay of free L‐T3 (400 fmol/L) was recorded using the microsensors based on HD/DP, while for the assay of free L‐T4, and D‐T4 the best limit of determination (1 pmol/L) was recorded using the TX/DP‐based microsensor. For the enantiorecognition of free L‐T3 in whole blood and pharmaceutical samples the best microsensor was the one based on HD/DP (the wider linear concentration range, and the lower limit of quantification – of pmol/L magnitude order). For the enantiorecognition of free L‐T3 in whole blood and pharmaceutical samples the best microsensor was the one based on HD/DP (the wider linear concentration range, and the lower limit of quantification – of pmol/L magnitude order). Free L‐T3, L‐T4, and D‐T4 were recovered with high reliabilities in whole blood samples (recoveries higher than 99.00%, with RSD values lower than 1.00%) and pharmaceutical samples (recoveries higher than 95.00% with RSD values lower than 1.00%). Chirality 27:973–978, 2015. © 2015 Wiley Periodicals, Inc.
Stopped‐Flow Enantioselective HPLC‐CD Analysis and TD‐DFT Stereochemical Characterization of Methyl Trans‐3‐(3,4‐Dimethoxyphenyl)Glycidate
Authors: Tedesco Daniele , Fabini Edoardo , Barbakadze Vakhtang , Merlani Maia , Zanasi Riccardo , Chankvetadze Bezhan , Bertucci Carlo 
Published: October 2015

AbstractCaffeic acid‐derived polyethers are a class of natural products isolated from the root extracts of comfrey and bugloss, which are endowed with intriguing pharmacological properties as anticancer agents. The synthesis of new polyether derivatives is achieved through ring‐opening polymerization of chiral 2,3‐disubstituted oxiranes, whose absolute configurations define the overall stereochemistry of the produced polymer. The absolute stereochemistry of one of these building blocks, methyl trans‐3‐(3,4‐dimethoxy‐phenyl)glycidate (3), was therefore characterized by the combination of enantioselective high‐performance liquid chromatography (HPLC), electronic circular dichroism (ECD) spectroscopy, and time‐dependent density functional theory (TD‐DFT) calculations. Initial efforts aiming at the isolation of enantiomers by means of a standard preparative HPLC protocol followed by offline ECD analysis failed due to unexpected degradation of the samples after collection. The stopped‐flow HPLC‐CD approach, by which the ECD spectra of enantiomers are measured online with the HPLC system, was applied to overcome this issue and allowed a fast, reliable, and chemical‐saving analysis, while avoiding the risks of sample degradation during the collection and processing of enantiomeric fractions. Subsequent TD‐DFT calculations identified ((2S,3R)-3 as the first eluted enantiomeric fraction on the Lux Cellulose‐2 column, therefore achieving a full stereochemical characterization of the chiral oxirane under investigation. Chirality 27:914–918, 2015. © 2015 Wiley Periodicals, Inc.
Design, Synthesis, and Photophysical Properties of Pyrroloquinoline‐Based Compounds Showing Strong Blue Fluorescence as Potential Dyes for Biomedical Applications
Authors: Carta Davide , Balasso Anna , Caliceti Paolo , Ferlin Maria Grazia 
Published: October 2015

AbstractA small library of 3‐ethylpyrrolo[3,2‐f]quinoline derivatives was synthesized to identify a novel class of dyes for use in biological studies. According to the spectroscopic analyses performed to evaluate the fluorimetric parameters of quantum yield and brightness, 7‐methyl‐ and 6,7‐dimethylpyrroloquinolin(9)one derivatives were found to be the best blue luminescent dyes for biological applications. To enhance the luminescence profiles and to obtain probes that could be conjugated to functional groups of supramolecular drug delivery systems, these compounds were further modified at position 3 to obtain 3‐heptanoic acid and 3‐aminohexylpyrroloquinolin(9)one methylated derivatives. The most brilliant 6,7‐dimethyl‐3‐aminohexylpyrroloquinolinone hydrochloride was conjugated to pullulan, a biocompatible polysaccharide used to produce colloidal systems for drug delivery. Comparative studies showed that this compound can be properly exploited as a blue fluorescent label in biological investigations, namely cell trafficking and pharmacokinetics/biodistribution studies. These molecules possess higher fluorescence efficiency than commercial dyes in biological media, making them suitable alternatives to commercially available products in current use.
Marital status, education, and income in relation to the risk of esophageal and gastric cancer by histological type and site
Authors: Lagergren Jesper , Andersson Gunnar , Talbäck Mats , Drefahl Sven , Bihagen Erik , Härkönen Juho , Feychting Maria , Ljung Rickard 
Published: October 2015

BACKGROUNDMarital status, income, and education might influence the risk of esophageal and gastric cancer, but the literature is limited. A large study addressing subtypes of these tumors was used to clarify these associations.METHODSA nationwide, Swedish population–based cohort study from 1991 to 2010 included individuals who were 50 years old or older. Data on exposures, covariates, and outcomes were obtained from well‐maintained registers. Four esophagogastric tumor subtypes were analyzed in combination and separately: esophageal adenocarcinoma, esophageal squamous cell carcinoma, cardia adenocarcinoma, and noncardia gastric adenocarcinoma. Poisson regression was used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Analyses were stratified by sex and adjusted for confounders.RESULTSAmong 4,734,227 participants (60,634,007 person‐years), 24,095 developed esophageal or gastric cancer. In comparison with individuals in a long marriage, increased IRRs were found among participants who were in a shorter marriage or were never married, remarried, divorced, or widowed. These associations were indicated for each tumor subtype but were generally stronger for esophageal squamous cell carcinoma. Higher education and income were associated with decreased IRRs in a seemingly dose‐response manner and similarly for each subtype. In comparison with the completion of only primary school, higher tertiary education rendered an IRR of 0.64 (95% CI, 0.60‐0.69) for men and an IRR of 0.68 (95% CI, 0.61‐0.75) for women. Comparing participants in the highest and lowest income brackets (highest 20% vs lowest 20%) revealed an IRR of 0.74 (95% CI, 0.70‐0.79) for men and an IRR of 0.83 (95% CI, 0.76‐0.91) for women.CONCLUSIONSDivorce, widowhood, living alone, low educational attainment, and low income increase the risk of each subtype of esophageal and gastric cancer. These associations require attention when high‐risk individuals are being identified. Cancer 2016;122:207–212. © 2015 American Cancer Society.
A benchmark for evaluation of algorithms for identification of cellular correlates of clinical outcomes
Authors: Aghaeepour Nima , Chattopadhyay Pratip , Chikina Maria , Dhaene Tom , Van Gassen Sofie , Kursa Miron , Lambrecht Bart N. , Malek Mehrnoush , McLachlan G. J. , Qian Yu , Qiu Peng , Saeys Yvan , Stanton Rick , Tong Dong , Vens Celine , Walkowiak Sławomir , Wang Kui , Finak Greg , Gottardo Raphael , Mosmann Tim , Nolan Garry P. , Scheuermann Richard H. , Brinkman Ryan R. 
Published: October 2015

AbstractThe Flow Cytometry: Critical Assessment of Population Identification Methods (FlowCAP) challenges were established to compare the performance of computational methods for identifying cell populations in multidimensional flow cytometry data. Here we report the results of FlowCAP‐IV where algorithms from seven different research groups predicted the time to progression to AIDS among a cohort of 384 HIV+ subjects, using antigen‐stimulated peripheral blood mononuclear cell (PBMC) samples analyzed with a 14‐color staining panel. Two approaches (FlowReMi.1 and flowDensity‐flowType‐RchyOptimyx) provided statistically significant predictive value in the blinded test set. Manual validation of submitted results indicated that unbiased analysis of single cell phenotypes could reveal unexpected cell types that correlated with outcomes of interest in high dimensional flow cytometry datasets. © 2015 International Society for Advancement of Cytometry
Axonal PPARγ promotes neuronal regeneration after injury
Authors: Lezana Juan Pablo , Dagan Shachar Y. , Robinson Ari , Goldstein Ronald S. , Fainzilber Mike , Bronfman Francisca C. , Bronfman Miguel 
Published: October 2015

ABSTRACTPPARγ is a ligand‐activated nuclear receptor best known for its involvement in adipogenesis and glucose homeostasis. PPARγ activity has also been associated with neuroprotection in different neurological disorders, but the mechanisms involved in PPARγ effects in the nervous system are still unknown. Here we describe a new functional role for PPARγ in neuronal responses to injury. We found both PPAR transcripts and protein within sensory axons and observed an increase in PPARγ protein levels after sciatic nerve crush. This was correlated with increased retrograde transport of PPARγ after injury, increased association of PPARγ with the molecular motor dynein, and increased nuclear accumulation of PPARγ in cell bodies of sensory neurons. Furthermore, PPARγ antagonists attenuated the response of sensory neurons to sciatic nerve injury, and inhibited axonal growth of both sensory and cortical neurons in culture. Thus, axonal PPARγ is involved in neuronal injury responses required for axonal regeneration. Since PPARγ is a major molecular target of the thiazolidinedione (TZD) class of drugs used in the treatment of type II diabetes, several pharmaceutical agents with acceptable safety profiles in humans are available. Our findings provide motivation and rationale for the evaluation of such agents for efficacy in central and peripheral nerve injuries. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 688–701, 2016
Electrochemical and Computational Study of the Reactivity of a Diiron Azadithiolate Complex towards Protons in the Presence of Coordinating Anions
Authors: Bourrez Marc , Gloaguen Frederic 
Published: October 2015

AbstractIn a continued effort to gain understanding of the impact of the second coordination sphere on the catalytic activity of the FeFe‐H2ase models, we report the results of an electrochemical and computational study of the reactivity of [Fe2(μ‐adtH)(CO)6] {1, adtH = (SCH2)2NH} towards protons in the presence of coordinating anions. The voltammetric behavior of 1 in the presence of HCl (pKa ≈ 9.5) in Bu4NPF6/MeCN is very similar to that of adtR derivatives in the presence of HBF4·Et2O (pKa ≈ 3), suggesting an effect of coordinating anion (i.e. Cl– or BF4–) rather than an effect of acid strength on the catalytic pathway. This hypothesis is supported by DFT calculations, which indicate a weak but significant interaction between Cl– and the proton of the amine group the closest to the metal center in the N‐protonated and reduced form of 1.
Diboranyl Phosphonium Cations: Synthesis and Chemical Properties
Authors: Litters Sebastian , Ganschow Michael , Kaifer Elisabeth , Himmel Hans‐Jörg 
Published: October 2015

AbstractHydride abstraction from the diborane [HB(hpp)]2 (hpp = 1,3,4,6,7,8‐hexahydro‐2H‐pyrimido[1,2‐a]pyrimidinate) followed by base stabilization led to the first (highly water sensitive) diboranyl phosphonium cations of the general formulas [HB(hpp)2BPR3]+ and [HB(hpp)2BPHR2]+. The B–P bond strength could be varied over a relatively large range by choice of the substituents R on the phosphine. The cation [HB(hpp)2BPCy3]+ (Cy = cyclohexyl) was structurally characterized. The PCy3 base of this cation could be substituted by a stronger base (a carbene or a bicyclic guanidine). In solution, [HB(hpp)2BPCy3]+ very slowly decomposes, and [HB(hpp)3BH]+ was identified as one of the decomposition products.
Luminescent Thermochromism in a Gold(I)–Copper(I) Phosphine–Pyridine Complex
Authors: Chen Kelly , Catalano Vincent J. 
Published: October 2015

AbstractThe AuI complex [Au(Ph2PCH2py)2]BF4 (1) was prepared by mixing (tetrahydrothiophene)gold(I) chloride with 2‐[(diphenylphosphino)methyl]pyridine (Ph2PCH2py) in dichloromethane. The addition of [Cu(NCCH3)4]BF4 to 1 produced green‐luminescent [AuCu(Ph2PCH2py)2(NCCH3)2](BF4)2 (2). When crystals of 2 were exposed to air, two acetonitrile molecules were lost to form crystals of yellow‐luminescent [AuCu(Ph2PCH2py)2](BF4)2 (3). This simple solvent loss perturbs the environment around the CuI center, and the Au···Cu distance shortens from 3.3 to 2.8 Å. Crystallization of 2 or 3 from dichloromethane produced the two‐coordinate CuI–solvate complex, [AuCu(Ph2PCH2py)2](BF4)2·CH2Cl2 (3·CH2Cl2). Compound 3 exhibits temperature‐dependent emissions from 77 to 298 K (543 nm), 298 to 343 K (551 nm), and above 343 K (505 nm) that is reversed upon return to room temperature. The low‐temperature emission is typical of complexes with luminescent rigidochromic properties. However, based on differential scanning calorimetry, a phase change is responsible for the high‐temperature emission of 3.
Palladium‐ and Nickel‐Catalyzed Synthesis of Sodium Acrylate from Ethylene, CO2, and Phenolate Bases: Optimization of the Catalytic System for a Potential Process
Authors: Manzini Simone , Huguet Núria , Trapp Oliver , Schaub Thomas 
Published: October 2015

AbstractThe synthesis of sodium acrylate through catalytic carboxylation of ethylene with CO2 in the presence of a base is a reaction of high interest. To develop a more efficient and sustainable method to access this valuable acrylate monomer, we optimized the system in a one‐step homogeneous nickel‐ or palladium‐catalyzed reaction, without the need for stoichiometric amounts of an additional reducing agent. Suitable nontoxic solvents such as anisole instead of the previously reported tetrahydrofuran or chlorobenzene were found to lead to acrylate formation. In combination with appropriate phenolate bases, this could allow a rational process concept for a simple catalyst recycling, product separation, and base regeneration.
Responses to exclusion are moderated by its perceived fairness
Authors: Tuscherer Taylor , Sacco Donald F. , Wirth James H. , Claypool Heather M. , Hugenberg Kurt , Wesselmann Eric D. 
Published: October 2015

AbstractExperimental exclusion manipulations may induce exclusion in a way that participants perceive as unfair. Groups often use exclusion punitively to correct inappropriate behavior, however, which may lead to perceptions that it is potentially justified or fair. The current studies examined if individuals' perceptions of fairness with respect to an exclusion experience moderated their reactions. Participants wrote about or imagined a time in which they were excluded after they did something wrong (fair exclusion) or excluded even though they did nothing wrong (unfair exclusion) or about a mundane experience unrelated to exclusion (control). Compared with fair exclusion, unfair exclusion resulted in significantly weaker efficacy needs satisfaction (Studies 1, 2, and 4), greater antisocial intent (Study 3), and greater sensitivity to signs of interpersonal acceptance and rejection in a visual search task (Study 4). These results suggest that it is important to consider the role of perceived fairness in shaping responses to exclusion.
The influence of solar‐induced thermal stresses on the mechanical weathering of rocks in humid mid‐latitudes
Authors: Aldred Jennifer , Eppes Martha Cary , Aquino Kimberly , Deal Rebecca , Garbini Jacob , Swami Suraj , Tuttle Alea , Xanthos George 
Published: October 2015

AbstractThe role of solar‐induced thermal stresses in the mechanical breakdown of rock in humid‐temperate climates has remained relatively unexplored. In contrast, numerous studies have demonstrated that cracks in rocks found in more arid mid‐latitude locations exhibit preferred northeast orientations that are interpreted to be a consequence of insolation‐related cracking. Here we hypothesize that similar insolation‐related mechanisms may be efficacious in humid temperate climates, possibly in conjunction with other mechanical weathering processes. To test this hypothesis, we collected rock and crack data from a total of 310 rocks at a forested field site in North Carolina (99 rocks, 266 cracks) and at forested and unforested field sites in Pennsylvania (211 rocks, 664 cracks) in the eastern United States. We find that overall, measured cracks exhibit statistically preferred strike orientations (47° ± 16), as well as dip angles (52° ± 24°), that are similar in most respects to comparable datasets from mid‐latitude deserts. There is less variance in strike orientations for larger cracks suggesting that cracks with certain orientations are preferentially propagated through time. We propose that diurnally repeating geometries of solar‐related stresses result in propagation of those cracks whose orientations are favorably oriented with respect to those stresses. We hypothesize that the result is an oriented rock heterogeneity that acts as a zone of weakness much like bedding or foliation that can, in turn, be exploited by other weathering processes. Observed crack orientations vary somewhat by location, consistent with this hypothesis given the different latitude and solar exposure of the field sites. Crack densities vary between field sites and are generally higher on north‐facing boulder‐faces and in forested sites, suggesting that moisture‐availability also plays a role in dictating cracking rates. These data provide evidence that solar‐induced thermal stresses facilitate mechanical weathering in environments where other processes are also likely at play. Copyright © 2015 John Wiley & Sons, Ltd.