bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fistula awareness among sisters of women with fistula
Authors: Zheng Alice X. , Harrington Alexander H. , Love Stephanie A. , Thélémaque Linda D. , Anderson Frank W.J. 
Published: December 2012

AbstractObjectiveTo determine whether sisters of women with obstetric fistula (OF) were aware of their sisters’ condition, in order to inform the development of survey questions that adapt the sister‐based method to fistula rate estimation.MethodsTwelve women with OF and 20 of their sisters were interviewed using semi‐structured questionnaires in rural Uganda in 2007. Topics included fistula awareness and perceptions of causality.ResultsEleven women had vesicovaginal fistula and 1 had rectovaginal fistula. Three were primiparous at time of fistula occurrence; 6 had a parity of 6 or more. Nineteen sisters were aware their sister had OF; 12 became aware at the time of occurrence. The majority of participants (fistula patients and their sisters) associated OF with mistakes made by hospital personnel or problems during procedures.ConclusionSisters were generally aware of OF within their family. Larger studies are needed to assess the validity and reliability of the sister‐based method in capturing fistula through household surveys. In the present study, there was a widespread perception among fistula patients and their sisters that fistula is caused by medical procedures. More research is needed to understand this perception, and program development efforts are required to improve patient perceptions of hospital care.
Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaints
Authors: van Harten Argonde C. , Visser Pieter Jelle , Pijnenburg Yolande A.L. , Teunissen Charlotte E. , Blankenstein Marinus A. , Scheltens Philip , van der Flier Wiesje M. 
Published: December 2012

AbstractBackgroundThe need to recognize Alzheimer's disease (AD) as early as possible led us to evaluate the predictive value of amyloid β(1‐42) (Aβ42), total tau (tau), and phosphorylated tau (ptau) in cerebrospinal fluid (CSF) for clinical progression in patients with subjective complaints.MethodsWe recruited nondemented patients with subjective complaints (i.e., criteria for mild cognitive impairment [MCI] not fulfilled) from our memory clinic. We assessed the predictive value of CSF Aβ42, tau, and ptau for clinical progression using Cox proportional hazards models adjusted for age, gender, and baseline findings on the Mini‐Mental State Examination (MMSE). Clinical progression was defined as progression to MCI or AD.ResultsWe included 127 patients with subjective complaints (age 60 ± 10 years, 61 [48%] females, MMSE 29 ± 1). At baseline, Aβ42 and tau were abnormal in 20 patients (both 16%), and ptau in 32 patients (25%). Thirteen patients (10%) progressed to MCI (n = 11) or AD (n = 2). Aβ42 was the strongest predictor of progression to MCI or AD with an adjusted hazard ratio (HR) of 16.0 (3.8–66.4). The adjusted HR associated with tau was 2.8 (0.9–9.2) and with ptau 2.6 (0.8–8.2). Combinations of biomarkers had a lower predictive value than Aβ42 alone.ConclusionLow Aβ42 was the strongest predictor of clinical progression in patients with subjective complaints. These results are in line with the hypothesis that the cascade of pathologic events starts with deposition of Aβ42, whereas neuronal degeneration and hyperphosphorylation of tau are more downstream events, closer to clinical manifestation of AD.
The enemy hypothesis: correlates of gall morphology with parasitoid attack rates in two closely related rose cynipid galls
Authors: László Z. , Tóthmérész B. 
Published: December 2012

AbstractWe tested the enemy hypothesis for gall morphology on a model system comprising twoDiplolepisrose gall wasp species and their associated parasitoids. The enemy hypothesis predicts both that gall traits will influence parasitoid attack rates within species, and that galls with contrasting morphologies will support different parasitoid communities. This hypothesis is supported by studies at both intraspecific and broader taxonomic levels (i.e. between genera), but patterns remain to be explored in closely related species. Our aims were to explore the relationships between aspects of gall morphology (number of larval chambers, overall gall size and thickness of the gall wall) in each ofDiplolepis mayriandD. rosae, and to explore correlations between these traits and both the presence/absence (=incidence) and attack rates imposed by parasitoids. We found in both galls that chamber number is positively correlated with gall size. In galls ofD. mayri, parasitoid incidence was negatively correlated with thickness of the wall of the larval chamber, but there was no significant correlation between parasitoid attack rates and overall gall size. InD. rosaegalls, parasitoid incidence was positively correlated with chamber wall thickness, but parasitoid attack rates were negatively correlated with gall size, suggesting that selection may favour the induction of galls containing more larval chambers. These results confirm that gall extended phenotypes can significantly influence enemy attack rates, consistent with the ‘enemy hypothesis’. Further, differences in gall morphology between the twoDiplolepisspecies may underlie differences in their associated parasitoid communities – further research is required to test this hypothesis.
Management of an incidental malignant peripheral nerve sheath tumour in the parapharyngeal space
Authors: Mushi E , Winter S 
Published: December 2012

AbstractBackground:Parapharyngeal space tumours are uncommon and represent 0.5–1 per cent of all head and neck neoplasms; 20–30 per cent of these are malignant. Malignant peripheral nerve sheath tumours are rare and mostly encountered in patients with neurofibromatosis type 1. Only four cases of parapharyngeal space tumours have been reported in the English language in patients without neurofibromatosis type 1.Case report:We report the case of a 64-year-old man with no stigmata of neurofibromatosis type 1, in whom a mass in the left pre-styloid region of the parapharyngeal space was an incidental finding following magnetic resonance imaging for investigation of cervical spine problems. The mass was consequently removed using a transcervical approach. A histological review revealed a low-grade malignant peripheral nerve sheath tumour.Discussion:We consider the pathophysiology of this highly malignant tumour as well as the challenging anatomy of the parapharyngeal space and the surgical and other therapeutic modalities utilised to treat this condition.
Intratympanic gentamicin treatment for unilateral Ménière's disease: long-term follow up of a proven regime
Authors: Wasson J , Upile N , Pfleiderer A 
Published: December 2012

AbstractObjective:To determine the long-term efficacy of a fixed-dose intratympanic gentamicin treatment regime in controlling unilateral Ménière's disease.Methods:Pfleiderer (1998) published two-year follow-up results for a series of 16 patients treated with a 4-day, 12-dose intratympanic gentamicin regime for unilateral Ménière's disease that was refractory to medical treatment. In 2010, a long-term telephone follow up (mean 17 years and 3 months) of this same cohort was conducted to determine long-term vertigo control. Of the 16 patients, 13 were eligible for the long-term follow up.Results:At 2 years' follow up, all 16 patients experienced substantial control of vertigo, with complete control achieved in 87 per cent of cases. At the long-term follow up, 9 of the 13 eligible patients were contactable, and all reported complete control of vertigo.Conclusion:Fixed-dose intratympanic gentamicin controlled symptomatic unilateral Ménière's disease in both the short and long term.
Unwitnessed lithium ion disc battery ingestion: case report and review of best practice management of an increasing clinical concern
Authors: Dawe N , Puvanendran M , Flood L 
Published: December 2012

AbstractObjective:To describe a case of unwitnessed lithium ion disc battery ingestion, with a review of radiology findings and current best practice management.Case report:A three-year-old girl presented following ingestion of a foreign body, which her four-year-old brother claimed was a one pound coin. The patient was managed non-urgently and transferred for specialist ENT assessment 6 hours following the initial ingestion, with no evidence of airway compromise. A corroded battery was removed from the level of the cricopharyngeus after 8 hours, with an associated circumferential mucosal burn.Conclusion:There is increasing concern regarding the acknowledged rising incidence of lithium ion disc battery ingestion. The lack of a high index of suspicion and the inability to recognise subtleties on imaging may lead to suboptimal management with a higher degree of unnecessary immediate and delayed morbidity. The recently published American Academy of Pediatrics Guidelines may guide the approach to managing battery ingestions.
Prevalence of preventable ear disorders in over 15 000 schoolchildren in northern India
Authors: Chadha S K , Sayal A , Malhotra V , Agarwal A K 
Published: December 2012

AbstractBackground:There is a considerable scarcity of reliable population-based data on the prevalence of preventable ear disorders in developing countries. This study was conducted to determine the prevalence of preventable ear disorders in primary school children (aged 5 to 12 years) in northern India.Method:A pro forma questionnaire was used to screen 15 718 primary school children in New Delhi for ear disorders. Ear examinations were conducted using otoscopy and impedance audiometry.Results:Impacted cerumen was prevalent in 7.93 per cent of schoolchildren, 4.79 per cent suffered from chronic otitis media and 3.06 per cent suffered from otitis media with effusion. Acute otitis media was detected in 0.65 per cent and foreign bodies were found in 0.34 per cent of the children.Conclusion:Preventable ear diseases posed a significant health problem among children at primary school level. Regular screening of children during this stage would ensure that their school lives were not affected by hearing impairments or preventable ear disorders. Information gathered in this study will help in effective treatment prioritisation of ear disorders, planning and resource allocation.
Double J stent of frontal sinus outflow tract in revision frontal sinus surgery
Authors: Mansour H A K A 
Published: December 2012

AbstractObjective:Frontal sinus surgery continues to challenge even the most experienced endoscopic sinus surgeon. Revision frontal sinus surgery is even more challenging. The use of stents in frontal sinus surgery has long been described, as an attempt to decrease the incidence of synechiae and stenosis.Method:This study included five patients who had previously undergone functional endoscopic sinus surgery but suffered recurrence of frontal sinusitis. Two had bilateral disease. Double J stents were used after endoscopic frontal sinusotomy. The stents were left in place for six months.Results:Four of the 5 patients (6 out of 7 sinuses) had a patent frontal outflow tract after 10 to 36 months’ follow up.Conclusion:Double J stents can be used as frontal sinus stents. They are well tolerated by patients, easily applied, and self-retaining with no need for sutures. The length of the stent can be altered according to the patient's anatomy and pathology.
True carcinosarcoma of the larynx
Authors: Zhang M , Zhao L-M , Li X-M , Zhou L , Lin L , Wang S-Y 
Published: December 2012

AbstractObjective:To explore the diagnosis and treatment of carcinosarcoma of the larynx.Methods:Clinical information, including presentation, pathology, treatment and outcome, was obtained from a review of patient charts.Results:Seven male patients were confirmed pathologically to have had carcinosarcoma between 2003 and 2009 in our hospital. All patients underwent surgery: four total laryngectomies, two vertical partial laryngectomies, and one supracricoid partial laryngectomy-cricohyoidopexy. The mean follow up was 40.6 months. At the time of writing, six patients were alive and being followed; two of these suffered regional metastasis to the cervical lymphatic nodes and underwent radical neck dissection. One patient died of multiple distant metastases 60 months post-operatively.Conclusion:Carcinosarcoma of the larynx describes a biphasic tumour showing both carcinomatous and sarcomatous differentiation. It is extraordinarily rare and prone to metastasise to the cervical lymph nodes. Complete surgical resection of laryngeal primary lesions with wide margins and suitable neck dissection of cervical nodes is reasonable therapy.
Biomolecular electrostatics and solvation: a computational perspective
Authors: Ren Pengyu , Chun Jaehun , Thomas Dennis G. , Schnieders Michael J. , Marucho Marcelo , Zhang Jiajing , Baker Nathan A. 
Published: December 2012

AbstractAn understanding of molecular interactions is essential for insight into biological systems at the molecular scale. Among the various components of molecular interactions, electrostatics are of special importance because of their long-range nature and their influence on polar or charged molecules, including water, aqueous ions, proteins, nucleic acids, carbohydrates, and membrane lipids. In particular, robust models of electrostatic interactions are essential for understanding the solvation properties of biomolecules and the effects of solvation upon biomolecular folding, binding, enzyme catalysis, and dynamics. Electrostatics, therefore, are of central importance to understanding biomolecular structure and modeling interactions within and among biological molecules. This review discusses the solvation of biomolecules with a computational biophysics view toward describing the phenomenon. While our main focus lies on the computational aspect of the models, we provide an overview of the basic elements of biomolecular solvation (e.g. solvent structure, polarization, ion binding, and non-polar behavior) in order to provide a background to understand the different types of solvation models.
“Fatal attraction” syndrome: Not a good way to keep your man
Authors: Campbell Anne 
Published: December 2012

AbstractFemale behavior that is driven by ambivalent attachment is far from passive or withdrawn. As dramatised in the movie “Fatal Attraction,” such women's emotional hyper-reactivity is often expressed in violence, which is antithetical to securing investment from mates or peers. Single motherhood, rather than reflecting an avoidant strategy in which close relationships are devalued, is often the result of ecological conditions in which paternal investment is desired but unavailable.
Attachment styles within sexual relationships are strategic
Authors: Symons Douglas K. , Szielasko Alicia L. 
Published: December 2012

AbstractDel Giudice's examination of sex differences in reproductive strategy within an attachment context is well taken. Sex has been studied as behavior within romantic relationships, but attachment styles should also be reflected in strategic behavior within relationships that are sexual. This seems particularly true within adolescence, and sex differences may be better reflected as differences in correlation patterns of process variables than as main effects models.
Learning grammatical gender: The use of rules by novice learners
Authors: PRESSON NORA , MacWHINNEY BRIAN , TOKOWICZ NATASHA 
Published: December 2012

ABSTRACTTwo experiments successfully trained novices to categorize French nouns by grammatical gender, resulting in high levels of performance after delay. Training with a frequent exemplar and training with a more diverse exemplar set led to equivalent learning. However, providing explicit rules with correctness feedback led to better generalization and retention than did correctness feedback alone or feature focusing without explicit rule information. This suggests that, at least for some grammar tasks, explicit information about form–function mappings improves learning. Moreover, the advantage of rule instruction was robust to testing and training under time pressure. Thus, rule instruction may be helpful even when speeded performance is required, supporting the prediction that practice leads to proceduralization of declarative grammatical knowledge.
Portal or pot hole? Exploring how older people use the ‘information superhighway’ for advice relating to problems with a legal dimension
Authors: DENVIR CATRINA , BALMER NIGEL J. , PLEASENCE PASCOE 
Published: December 2012

ABSTRACTAs an increasing number of Government services have moved away from traditional modes of provision to online formats, there has been a corresponding need to ensure greater access to the internet. Although older people (those over 60) are least likely of all age groups to have access to the internet in their homes, the internet holds much potential as an information and advice resource for those older people who may find it difficult to access advice over the telephone or in person. Realising this potential extends beyond issues of physical access; consideration must necessarily be given to issues of internet literacy and the inclination of this cohort to utilise what may be new and unfamiliar technology. This paper examines these matters in the context of the resolution of everyday problems with a legal dimension. Looking first at the use of the internet for information and advice seeking related to such problems, we find that those aged over 60 demonstrate the least use of the internet for problems with a legal dimension. Simultaneously, those aged over 60 are also the group with the lowest level of home access – a particular issue given that for over 60-year-olds, home access is a far stronger determinant of internet use for problems than it is for other age groups. Examining use of the internet for advice seeking over the last decade, findings demonstrate the existence of a general increase in use amongst all age groups over time, albeit with a lower rate of growth amongst those currently over 60. As an indication of future growth, this will have implications for the provision of services. Whilst the ‘young old’ will utilise the internet to a greater degree and will require websites which are tailored to their needs, those individuals at the older end of the age spectrum may best be served by continued access to face-to-face or outreach advice. The implications these findings pose for policy makers in setting priorities in the remit of online service provision are discussed, with results having particular relevance in England and Wales given planned changes to civil legal aid.
Satisfaction with the Standard of Living in Reform-Era China
Authors: Han Chunping 
Published: December 2012

AbstractPopular satisfaction with current standards of living in reform-era China is explored in this article, using survey data from the 2004 China Inequality and Distributive Justice Project. Three major patterns are found: first, people of rural origin, with low levels of education and living in the west region, who are disadvantaged in the inequality hierarchy, report greater satisfaction with current standards of living than do privileged urbanites, the highly educated and residents in the coastal east. Second, inequality-related negative life experiences and social cognitive processes including temporal and social comparisons, material aspirations, and life goal orientations mediate the effects of socioeconomic characteristics. Third, the social sources of satisfaction with current standards of living vary across urban, rural and migrant residents. It is suggested that these patterns have largely stemmed from the unique political economic institutional arrangement and stratification system in China.
Stability and Change in Financial Transfers from Adult Children to Older Parents
Authors: Szinovacz Maximiliane E. , Davey Adam 
Published: December 2012

RÉSUMÉNous avons cherché à identifier l’ampleur et les facteurs prédictifs de l’évolution longitudinale de l’aide financière aux parents des descendants adultes et des réseaux de transferts pendant une période de deux ans. Les analyses s’appuyent sur les données regroupées de l’Étude de la Santé et de la Retraite (1994–2000), utilisant les familles dans lesquelles les descendants adultes ont au moins un, mais pas plus de quatre frères et sœurs, qui ont fourni un soutien financier aux parents pendant deux ans. Certains changements dans le réseau d’aide surviennent dans environ 40 pour cent de ces familles au cours de la période de deux ans. Quand le changement se produit, il s’agit le plus souvent de la cessation du soutien par un enfant, suivie par l’addition d’un nouvel enfant au réseau, alors que l’échange de soutien aux enfants est relativement rare. Le changement reflète la capacité de la progéniture avant tout à fournir des soins et le fardeau créé par les besoins des parents. Cependant, la taille et la composition du réseau adulte-enfant et du groupe de soutien initial jouaient un rôle important aussi bien. Les résultats soulignent le caractère dynamique et systémique des réseaux financiers intergénérationnels.
Patents, Biopolitics, and Feminisms: Locating Patent Law Struggles over Breast Cancer Genes and theHoodiaPlant
Authors: Foster Laura A. 
Published: December 2012

AbstractThis article suggests three critical inquiries for formulating a feminist analysis of patent law. The first questions how patent law functions as a strategy within neoliberal, biopolitics. The second examines how patent law is structured through biopolitical techniques of governance by examining two conceptions of the public domain I callopen public domainandprotective public domain. The third inquiry, drawing upon feminist science studies, asks how women's reproductive and intellectual labor are valued and devalued in various different ways through new patent law technologies. In addition, two recent patent law are struggles are examined. These include an American Civil Liberties Union case against the patenting of breast cancer gene sequences and Southern African San struggles against patents related to theHoodia gordoniiplant. In conclusion, I argue that patent law functions within gendered and ethno-racialized forms of neoliberal, biopolitics involving the patenting of women's reproductive and intellectual labor within new bioeconomics.
Protecting Traditional Knowledge Holders' Interests and Preventing Misappropriation—Traditional Knowledge Commons and Biocultural Protocols: Necessary but Not Sufficient?
Authors: Srinivas Krishna Ravi 
Published: December 2012

AbstractThe experience of the indigenous communities regarding access and benefit sharing under the national regimes based on provisions of Convention on Biological Diversity and Bonn Guidelines has not been satisfactory. The communities expect that noncommercial values should be respected and misappropriation should be prevented. Some academics and civil society groups have suggested that traditional knowledge commons and biocultural protocols will be useful in ensuring that while noncommercial values are respected, access and benefit sharing takes place on conditions that are acceptable to the communities. This proposal is examined in this context in the larger context of access and benefit sharing under the Convention on Biological Diversity and implementing prior informed consent principles in access and benefit sharing. This article examines knowledge commons, provides examples from constructed commons in different sectors and situates traditional knowledge commons in the context of debates on commons and public domain. The major shortcomings of traditional commons and bicultural protocol are pointed out, and it is suggested that these are significant initiatives that can be combined with the Nagoya Protocol to fulfill the expectations of indigenous communities.