bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrothermal Synthesis, Structure, and Optical Properties of Two Nanosized Ln26@CO3 (Ln=Dy and Tb) Cluster‐Based Lanthanide–Transition‐Metal–Organic Frameworks (Ln MOFs)
Authors: Zhang Yu , Huang Lian , Miao Hao , Wan Hong Xiang , Mei Hua , Liu Ying , Xu Yan 
Published: December 2014

AbstractTwo Ln26@CO3 (Ln=Dy and Tb) cluster‐based lanthanide–transition‐metal–organic frameworks (Ln MOFs) formulated as [Dy26Cu3(Nic)24(CH3COO)8(CO3)11(OH)26(H2O)14]Cl ⋅3 H2O (1; HNic=nicotinic acid) and [Tb26NaAg3(Nic)27(CH3COO)6(CO3)11(OH)26Cl(H2O)15]⋅7.5 H2O (2) have been successfully synthesized by hydrothermal methods and characterized by IR, thermogravimetric analysis (TGA), elemental analysis, and single X‐ray diffraction. Compound 1 crystallizes in the monoclinic space group Cc with a=35.775(12) Å, b=33.346(11) Å, c=24.424(8) Å, β=93.993(5)°, V=29065(16) Å3, whereas 2 crystallizes in the triclinic space group P with a=20.4929(19) Å, b=24.671(2) Å, c=29.727(3) Å, α=81.9990(10)°, β=88.0830(10)°, γ=89.9940(10)°, V=14875(2) Å3. Structural analysis indicates the framework of 1 is a 3D perovskite‐like structure constructed out of CO3@Dy26 building units and Cu+ centers by means of nicotinic acid ligand bridging. In 2, however, nanosized CO3@Tb26 units and [Ag3Cl]2+ centers are connected by Nic− bridges to give rise to a 2D structure. It is worth mentioning that this kind of 4d–4f cluster‐based MOF is quite rare as most of the reported analogous compounds are 3d–4f ones. Additionally, the solid‐state emission spectra of pure compound 2 at room temperature suggest an efficient energy transfer from the ligand Nic− to Tb3+ ions, which we called the “antenna effect”. Compound 2 shows a good two‐photon absorption (TPA) with a TPA coefficient of 0.06947 cm GM−1 (1 GM=10−50 cm4 s photon−1), which indicates that compound 2 might be a good choice for third‐order nonlinear optical materials.
Metal Complexes of a Boron‐Dipyrromethene (BODIPY)‐Tagged N‐Heterocyclic Carbene (NHC) as Luminescent Carbon Monoxide Chemodosimeters
Authors: Kos Pavlo , Plenio Herbert 
Published: December 2014

AbstractSeveral metal complexes with a boron dipyrromethene (BODIPY)‐functionalized N‐heterocyclic carbene (NHC) ligand 4 were synthesized. The fluorescence in [(4)(SIMes)RuCl2(ind)] complex is quenched (Φ=0.003), it is weak in [(4)PdI2(Clpy)] (Φ=0.033), and strong in [(4)AuI] (Φ=0.70). The BODIPY‐tagged complexes can experience pronounced changes in the brightness of the fluorophore upon ligand‐exchange and ligand‐dissociation reactions. Complexes [(4)MX(1,5‐cyclooctadiene)] (M=Rh, Ir; X=Cl, I; Φ=0.008–0.016) are converted into strongly fluorescent complexes [(4)MX(CO)2] (Φ=0.53–0.70) upon reaction with carbon monoxide. The unquenching of the Rh and Ir complexes appears to be a consequence of the decreased electron density at Rh or Ir in the carbonyl complexes. In contrast, the substitution of an iodo ligand in [(4)AuI] by an electron‐rich thiolate decreases the brightness of the BODIPY fluorophore, rendering the BODIPY as a highly sensitive probe for changes in the coordination sphere of the transition metal.
A Bowl‐Shaped Circular Trinuclear Helicate Generated from a TiO4N2 Motif by a Multicomponent Self‐Assembly Approach
Authors: Mobian Pierre , Baradel Nathalie , Kyritsakas Nathalie , Khalil Georges , Henry Marc 
Published: December 2014

AbstractThe synthesis of a bowl‐shaped trinuclear circular titanium‐based helicate is reported. The strategy allowing access to this neutral architecture is based on a multicomponent self‐assembly approach in which the ligands involved in the process are a bis‐biphenol strand and 2,2′‐ bipyrimidine. By reacting the bis‐biphenol ligand and 2,2′‐bipyrimidine with an equimolar amount [Ti(OiPr)4], a bowl‐shaped architecture is obtained through the formation of 18 new coordination bonds. This aggregate built from three octahedral TiO4N2 nodes displays an unusually high stability in solution compared to related species. In addition, by modifying the stoichiometry of the initial components, two assemblies incorporating two titanium centers bridged by a 2,2′‐bipyrimidine ligand are obtained. The crystal structures of these species are reported.
Control over Nanostructures and Associated Mesomorphic Properties of Doped Self‐Assembled Triarylamine Liquid Crystals
Authors: Domoto Yuya , Busseron Eric , Maaloum Mounir , Moulin Emilie , Giuseppone Nicolas 
Published: December 2014

AbstractWe have synthesized a series of triarylamine‐cored molecules equipped with an adjacent amide moiety and dendritic peripheral tails in a variety of modes. We show by 1H NMR and UV/Vis spectroscopy that their supramolecular self‐assembly can be promoted in solution upon light stimulation and radical initiation. In addition, we have probed their molecular arrangements and mesomorphic properties in the bulk by integrated studies on their film state by using differential scanning calorimetry (DSC), variable‐temperature polarizing optical microscopy (VT‐POM), variable‐temperature X‐ray diffraction (VT‐XRD), and atomic force microscopy (AFM). Differences in the number and the disposition of the peripheral tails significantly affect their mesomorphic properties associated with their lamellar‐ or columnar‐packed nanostructures, which are based on segregated stacks of the triphenylamine cores and the lipophilic/lipophobic periphery. Such structural tuning is of interest for implementation of these soft self‐assemblies as electroactive materials from solution to mesophases.
Peptoid‐Ligated Pentadecanuclear Yttrium and Dysprosium Hydroxy Clusters
Authors: Thielemann Dominique T. , Wagner Anna T. , Lan Yanhua , Oña‐Burgos Pascual , Fernández Ignacio , Rösch Esther S. , Kölmel Dominik K. , Powell Annie K. , Bräse Stefan , Roesky Peter W. 
Published: December 2014

AbstractA new family of pentadecanuclear coordination cluster compounds (from now on simply referred to as clusters) [{Ln15(OH)20(PepCO2)10(DBM)10Cl}Cl4] (PepCO2=2‐[{3‐(((tert‐butoxycarbonyl)amino)methyl)benzyl}amino]acetate, DBM=dibenzoylmethanide) with Ln=Y and Dy was obtained by using the cell‐penetrating peptoid (CPPo) monomer PepCO2H and dibenzoylmethane (DBMH) as supporting ligands. The combination of an inorganic cluster core with an organic cell‐penetrating peptoid in the coordination sphere resulted in a core component {Ln15(μ3‐OH)20Cl}24+ (Ln=Y, Dy), which consists of five vertex‐sharing heterocubane {Ln4(μ3‐OH)4}8+ units that assemble to give a pentagonal cyclic structure with one Cl atom located in the middle of the pentagon. The solid‐state structures of both clusters were established by single‐crystal X‐ray crystallography. MS (ESI) experiments suggest that the cluster core is robust and maintained in solution. Pulsed gradient spin echo (PGSE) NMR diffusion measurements were carried out on the diamagnetic yttrium compound and confirmed the stability of the cluster in its dicationic form [{Y15(μ3‐OH)20(PepCO2)10(DBM)10Cl}Cl2]2+. The investigation of both static (dc) and dynamic (ac) magnetic properties in the dysprosium cluster revealed a slow relaxation of magnetization, indicative of single‐molecule magnet (SMM) behavior below 8 K. Furthermore, the χT product as a function of temperature for the dysprosium cluster gave evidence that this is a ferromagnetically coupled compound below 11 K.
Approach to High Open‐Circuit Voltage in Organic Solar Cells Utilizing a Structural Change of the Oxazolino‐C70 Derivative
Authors: Li Shu‐Hui , Li Zong‐Jun , Nakagawa Takafumi , Ryan James W. , Matsuo Yutaka , Gao Xiang 
Published: December 2014

AbstractReactions of 2,5‐Bn2C70 (Bn=CH2Ph) with hydroxide and ArCN (Ar=Ph, m‐ClPh) followed by quenching with I2 and BnBr afforded dibenzylated and tetrabenzylated oxazolino[70]fullerenes, respectively. The latter has a novel structural configuration, in which the addends are positioned from the polar to the transequatorial region. A key structural feature of this compound is that the oxygen atom of the oxazoline ring is bound to the equatorial belt region of C70, giving structural change in its reduced state. This enables stabilization of the reduced state, suppressing charge recombination dynamics in organic solar cells to give a high open‐circuit voltage (0.85, 0.93, and 1.11 V in devices using P3HT, PTB7, and DPP(TBFu)2, respectively).
Synthesis of (±)‐Spongiolactone Enabling Discovery of a More Potent Derivative
Authors: Harvey Natalie L. , Krysiak Joanna , Chamni Supakarn , Cho Sung Wook , Sieber Stephan A. , Romo Daniel 
Published: December 2014

AbstractAn eleven‐step synthesis of (±)‐spongiolactone from 1,3‐cyclohexanedione is reported that relies on a diastereoselective, nucleophile‐catalyzed aldol lactonization (NCAL) process with an advanced ketoacid intermediate that installed the anticipated β‐lactone pharmacophore of the natural product. In addition, a stereoselective cyclohexenyl zinc addition to a substituted cyclohexanone simultaneously installed two fully substituted vicinal stereocenters. The reported synthesis enabled preliminary structure–activity studies that revealed a regio‐ and stereoisomeric derivative of spongiolactone with greater antiproliferative activity towards a leukemia (K562) cell line. Furthermore, unusual antiproliferative selectivity of these spongiolactone derivatives toward the K562 cell line was observed with no inhibition of the breast, liver, and lung cancer cell lines tested.
Friedelin aus Kork
Authors: Seupel Raina , Roth Alexander , Steinke Katrin , Sicker Dieter , Siehl Hans‐Ullrich , Zeller Klaus‐Peter , Berger Stefan 
Published: December 2014

AbstractDer Kork der Korkeiche ist ein faszinierendes Naturmaterial, das seit der Antike genutzt wird. Kork war 1665 auch Namensgeber für die “Zelle” in der Biologie. Friedelin, ein kompliziertes pentacyclisches Triterpenketon, ist ein Korkbestandteil. Wir beschreiben seine Isolierung und berichten über seine Historie. Alle analytischen Spektren sind vollständig entweder im Hauptteil oder in der supporting information wiedergegeben. Die NMR‐ sowie die Massenspektren werden eingehend interpretiert und mit theoretischen Berechnungen der 13C chemischen Verschiebungen verglichen. Das Projekt stellt eine Fortsetzung des Buches “Classics in Spectroscopy” von S. Berger und D. Sicker (Wiley‐VCH 2009) dar.
Die Ostsee atmet auf
Authors: Naumann Michael , Nausch Günther 
Published: December 2014

AbstractAktuelle Messdaten zur Umweltüberwachung der Ostsee zeigen einen größeren Einstrom von sauerstoffreichem Salzwasser aus der Nordsee an. Zum ersten Mal seit 2003 wurde das Tiefenwasser der zentralen Ostsee mit größeren Mengen von Sauerstoff versorgt und Schwefelwasserstoff verdrängt. Dieser Effekt wurde durch ein Zusammenwirken mehrerer kleiner Einstromphasen im Winter bis Frühjahr 2013/2014 ausgelöst, die die Wirkung eines in der Fachterminologie als “Major Baltic Inflow” (MBI) bezeichneten Salzwassereinbruchs erzielen. Ende Juli 2014 wurde das Gotlandtief (240 m Wassertiefe, Abbildung 1) von diesen Wassermassen erreicht und die durch langanhaltende Stagnation gekennzeichneten schlechten Umweltbedingungen des Tiefenwassers wurden verbessert.
Phosphatfreie Seife
Authors: Feil Sylvia 
Published: December 2014

AbstractSilanole haben die gleichen funktionellen Gruppen wie die in der Natur vorkommende Kieselsäue, industriell sind sie Vorläufer für Polysiloxane, also Silicone. Sie kondensieren sehr leicht, sind aber über ihre Verknüpfung gut steuerbar in Richtung Siliconöle oder Siliconharze. Bisher wurde aber wenig untersucht, wie sich gelöste Silanole verhalten. Die Idee, sie als grenzflächenaktiven Stoff zu verwenden, überraschte.
Tunable Nonlinear Optical Property and Photocatalytic Activity on Luminescent Chiral Lanthanide Chains
Authors: Qu Mei , Liu Minmin , Liu Jiang , Zhang Xianming 
Published: December 2014

AbstractFive chiral (P21) isostructural lanthanide coordination complexes Ln(pic)3 [pic=picolinic acid, Ln=La (1), Gd (2), Nd (3), Sm (4) and Eu (5)] have been hydrothermally generated, featuring one dimensional right‐handed 21 helical chains constructed from LnN3O6 of square antiprism geometry and N,O‐chelated pic− groups, in which 3, 4 and 5 have been reported, but we explore undiscovered properties of their own systematically. In special, 1 undergoes an abnormal transformation of symmetry as the temperature cooling to 100 K. TG‐DSC studies demonstrated that all isologues have good thermal stability with the decomposition temperature up to 400°C. Then, UV‐Vis‐NIR transmission spectroscopy measurements indicated that they possess a short‐wavelength absorption edge onset at 377 nm, corresponding to the optical band gap of 3.29 eV. Meanwhile, powder second harmonic generation (SHG) measurements revealed that the SHG intensity of 1, 2, 4 and 5 may be about 1.2, 2.0, 0.9 and 0.75 times that of KH2PO4, respectively. Interestingly, 1 and 3 exhibit efficient photocatalytic degradation for MB (Methylene Blue) upon UV‐light irradiation. Moreover, both 1 and 2 show strong blue luminescence.
The Impact of Processes of Care on Myocardial Infarct Size in Patients With ST‐Segment Elevation Myocardial Infarction: Observations From the CRISP‐AMI Trial
Authors: Jones W. Schuyler , Clare Robert M. , Chiswell Karen , Perera Divaka , French John K. , Kumar A. Sreenivas , Blaxill Jonathan , Pijls Nico , Mills James , Ohman E. Magnus , Patel Manesh R. 
Published: December 2014

AbstractBackgroundPrimary percutaneous coronary intervention (PCI) is the most common method of reperfusion in patients with ST‐segment elevation myocardial infarction (STEMI) in the United States. The intersection between processes of care and performance measures such as door‐to‐balloon (D2B) times and clinical trials evaluating novel therapies for STEMI has not been fully investigated.HypothesisProcesses of STEMI care, incorporating clinical trial enrollment and randomization, in patients undergoing reperfusion with primary PCI in the Counterpulsation Reduces Infarct Size Pre–Percutaneous Coronary Intervention Acute Myocardial Infarction trial (CRISP‐AMI) will conform to current standards of care.MethodsPatients enrolled in CRISP‐AMI were included in the current analysis. Processes of care during reperfusion were recorded prospectively and compared between groups.ResultsA total of 337 patients with anterior STEMI without cardiogenic shock were randomized in CRISP‐AMI. Complete processes‐of‐care data were available for 303 patients (89.9%). In this cohort, 68.0% of patients underwent reperfusion within 90 minutes of hospital contact, and the median D2B time was 71 minutes. Time from hospital contact to informed consent was significantly different across different regions (North America, 45 minutes; India, 35 minutes; Europe, 20 minutes).ConclusionsIn CRISP‐AMI, reperfusion was accomplished in a timely fashion while incorporating informed consent and randomization among patients with anterior myocardial infarction. Further study of patients' comprehension and preferences during the informed‐consent process in STEMI patients is warranted so that innovative drugs and devices can be safely and ethically tested.
The use of adjuvant radiotherapy in elderly patients with early‐stage breast cancer: Changes in practice patterns after publication of Cancer and Leukemia Group B 9343
Authors: Palta Manisha , Palta Priya , Bhavsar Nrupen A. , Horton Janet K. , Blitzblau Rachel C. 
Published: December 2014

BACKGROUNDThe Cancer and Leukemia Group B (CALGB) 9343 randomized phase 3 trial established lumpectomy and adjuvant therapy with tamoxifen alone, rather than both radiotherapy and tamoxifen, as a reasonable treatment course for women aged >70 years with clinical stage I (AJCC 7th edition), estrogen receptor‐positive breast cancer. An analysis of the Surveillance, Epidemiology, and End Results (SEER) registry was undertaken to assess practice patterns before and after the publication of this landmark study.METHODSThe SEER database from 2000 to 2009 was used to identify 40,583 women aged ≥70 years who were treated with breast‐conserving surgery for clinical stage I, estrogen receptor‐positive and/or progesterone receptor‐positive breast cancer. The percentage of patients receiving radiotherapy and the type of radiotherapy delivered was assessed over time. Administration of radiotherapy was further assessed across age groups; SEER cohort; and tumor size, grade, and laterality.RESULTSApproximately 68.6% of patients treated between 2000 and 2004 compared with 61.7% of patients who were treated between 2005 and 2009 received some form of adjuvant radiotherapy (P < .001). Coinciding with a decline in the use of external beam radiotherapy, there was an increase in the use of implant radiotherapy from 1.4% between 2000 and 2004 to 6.2% between 2005 to 2009 (P < .001). There were significant reductions in the frequency of radiotherapy delivery over time across age groups, tumor size, and tumor grade and regardless of laterality (P < .001 for all).CONCLUSIONSRandomized phase 3 data support the omission of adjuvant radiotherapy in elderly women with early‐stage breast cancer. Analysis of practice patterns before and after the publication of these data indicates a significant decline in radiotherapy use; however, nearly two‐thirds of women continue to receive adjuvant radiotherapy. Cancer 2015;121:188–93. © 2014 American Cancer Society.
Radiation for diffuse large B‐cell lymphoma in the rituximab era: Analysis of the National Comprehensive Cancer Network lymphoma outcomes project
Authors: Dabaja Bouthaina S. , Vanderplas Ann M. , Crosby‐Thompson Allison L. , Abel Gregory A. , Czuczman Myron S. , Friedberg Jonathan W. , Gordon Leo I. , Kaminski Mark , Niland Joyce , Millenson Michael , Nademanee Auayporn P. , Zelenetz Andrew , LaCasce Ann S. , Rodriguez Maria Alma 
Published: December 2014

BACKGROUNDThe role of consolidation radiotherapy was examined for patients with diffuse large B‐cell lymphoma who were treated at institutions of the National Comprehensive Cancer Network during the rituximab era.METHODSFailure‐free survival (FFS) and overall survival (OS) were analyzed in terms of patient and treatment characteristics. Potential associations were investigated with univariate and multivariate survival analysis and matched pair analysis.RESULTSThere were 841 patients, and most (710 or 84%) received 6 to 8 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP); 293 (35%) received consolidation radiation therapy (RT). Failure occurred for 181 patients: 126 patients (70%) who did not receive RT and 55 patients (30%) who did. At 5 years, both OS and FFS rates were better for patients who had received RT versus those who did not (OS, 91% vs 83% [P = .01]; FFS, 83% vs 76% [P = .05]). A matched pair analysis (217 pairs matched by age, stage, International Prognostic Index [IPI] score, B symptoms, disease bulk, and response to chemotherapy) showed that the receipt of RT improved OS (hazard ratio [HR], 0.53 [P = .07]) and FFS (HR, 0.77 [P = .34]) for patients with stage III/IV disease, but too few events took place among those with stage I/II disease for meaningful comparisons (HR for OS, 0.94 [P = .89]; HR for FFS, 1.81 [P = .15]). A multivariate analysis suggested that the IPI score and the response to chemotherapy had the greatest influence on outcomes.CONCLUSIONSThere was a trend of higher OS and FFS rates for patients who had received consolidation RT after R‐CHOP (especially for patients with stage III/IV disease), but the difference did not reach statistical significance. Cancer 2014. © 2014 American Cancer Society. Cancer 2015;121:1032–1039. © 2014 American Cancer Society.
Cost‐effectiveness of patient navigation to increase adherence with screening colonoscopy among minority individuals
Authors: Ladabaum Uri , Mannalithara Ajitha , Jandorf Lina , Itzkowitz Steven H. 
Published: December 2014

BACKGROUNDColorectal cancer (CRC) screening is underused by minority populations, and patient navigation increases adherence with screening colonoscopy. In this study, the authors estimated the cost‐effectiveness of navigation for screening colonoscopy from the perspective of a payer seeking to improve population health.METHODSA validated model of CRC screening was informed with inputs from navigation studies in New York City (population: 43% African American, 49% Hispanic, 4% white, 4% other; base‐case screening: 40% without navigation, 65% with navigation; navigation costs: $29 per colonoscopy completer, $21 per noncompleter, $3 per non‐navigated individual). Two analyses compared: 1) navigation versus no navigation for 1‐time screening colonoscopy in unscreened individuals aged ≥50 years; and 2) programs of colonoscopy with versus without navigation versus fecal occult blood testing (FOBT) or fecal immunochemical testing (FIT) for individuals ages 50 to 80 years.RESULTSIn the base case: 1) 1‐time navigation gained quality‐adjusted life‐years (QALYs) and decreased costs; 2) longitudinal navigation cost $9800 per QALY gained versus no navigation, and, assuming comparable uptake rates, it cost $118,700 per QALY gained versus FOBT but was less effective and more costly than FIT. The results were most dependent on screening participation rates and navigation costs: 1) assuming a 5% increase in screening uptake with navigation, and a navigation cost of $150 per completer, 1‐time navigation cost $26,400 per QALY gained; and 2) longitudinal navigation with 75% colonoscopy uptake cost <$25,000 per QALY gained versus FIT when FIT uptake was <50%. Probabilistic sensitivity analyses did not alter the conclusions.CONCLUSIONSNavigation for screening colonoscopy appears to be cost‐effective, and 1‐time navigation may be cost‐saving. In emerging health care models that reward outcomes, payers should consider covering the costs of navigation for screening colonoscopy.Cancer 2015;121:1088–1097.©2014 American Cancer Society.
US breast cancer mortality trends in young women according to race
Authors: Ademuyiwa Foluso O. , Gao Feng , Hao Lin , Morgensztern Daniel , Aft Rebecca L. , Ma Cynthia X. , Ellis Matthew J. 
Published: December 2014

BACKGROUNDYoung age at diagnosis has a negative prognostic impact on outcome in patients with breast cancer (BC). In the current study, the authors sought to determine whether there is a differential effect of race and examined mortality trends according to race and age.METHODS: The Surveillance, Epidemiology, and End Results program was used to identify women aged <50 years with invasive BC diagnosed between 1990 and 2009. Multivariate regression analyses were performed to determine the risk‐adjusted likelihood of survival for white and black patients. Annual hazards of BC death according to race and calendar period and adjusted relative hazards of death for white and black women stratified by age were computed.RESULTSA total of 162,976 women were identified, 126,573 of whom were white, 20,405 of whom were black, and 15,998 of whom were of other races. At a median follow‐up of 85 months, the 5‐year disease specific survival rates were 90.1% for white patients and 79.3% for black patients. Annual hazards of death in white patients decreased by 26% at 5 years after diagnosis in contrast to the hazards in black patients, which decreased by only 19%. With 1990 as the referent year, the adjusted relative hazards of death in women aged <40 years in 2005 were 0.55 (95% confidence interval [95% CI], 0.46‐0.66) and 0.68 (95% CI, 0.49‐0.93), respectively, for white and black women. In women aged 40 to 49 years, adjusted hazards of death were 0.53 (95% CI, 0.47‐0.60) and 0.78 (95% CI, 0.61‐0.99), respectively, for white and black women.CONCLUSIONSAmong young women diagnosed with BC, black patients have a worse outcome compared with white patients. Mortality declines have been observed over time in both groups, although more rapid gains have been reported to occur in white women. Emphasis should be placed on improving outcomes for young patients with BC. Cancer 2015;121:1469–1476. © 2014 American Cancer Society.