bluuebunny/crossref_metadata_2025_split huggingface dataset:
6-C-(E-phenylethenyl)-Naringenin Suppresses Colorectal Cancer Growth by Inhibiting Cyclooxygenase-1
Authors: Li Haitao , Zhu Feng , Chen Hanyong , Cheng Ka Wing , Zykova Tatyana , Oi Naomi , Lubet Ronald A. , Bode Ann M. , Wang Mingfu , Dong Zigang 
Published: November 2013

Abstract
Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors and cyclooxygenase-1 (COX-1) is now being reconsidered as a target for chemoprevention. Our aims were to determine whether selective COX-1 inhibition could delay or prevent cancer development and also clarify the underlying mechanisms. Data clearly showed that COX-1 was required for maintenance of malignant characteristics of colon cancer cells or tumor promoter-induced transformation of preneoplastic cells. We also successfully applied a ligand-docking computational method to identify a novel selective COX-1 inhibitor, 6-C-(E-phenylethenyl)-naringenin (designated herein as 6CEPN). 6CEPN could bind to COX-1 and specifically inhibited its activity both in vitro and ex vivo. In colorectal cancer cells, it potently suppressed anchorage-independent growth by inhibiting COX-1 activity. 6CEPN also effectively suppressed tumor growth in a 28-day colon cancer xenograft model without any obvious systemic toxicity. Taken together, COX-1 plays a critical role in human colorectal carcinogenesis, and this specific COX-1 inhibitor merits further investigation as a potential preventive agent against colorectal cancer. Cancer Res; 74(1); 243–52. ©2013 AACR.
A Genome-Wide Association Study of Renal Cell Carcinoma among African Americans
Authors: Purdue Mark P. , Ye Yuanqing , Wang Zhaoming , Colt Joanne S. , Schwartz Kendra L. , Davis Faith G. , Rothman Nathaniel , Chow Wong-Ho , Wu Xifeng , Chanock Stephen J. 
Published: November 2013

Abstract
Genome-wide association studies (GWAS) of renal cell carcinoma (RCC) in populations of European ancestry have identified four susceptibility loci. No GWAS has been conducted among African Americans (AA), who experience a higher incidence of RCC. We conducted a GWAS in which we analyzed 1,136,723 common single-nucleotide polymorphisms (SNP) among 255 cases and 375 controls of African ancestry, and further investigated 16 SNPs in a replication set (140 cases and 543 controls). The 12p11.23 variant rs10771279, located 77 kb from the European-ancestry RCC marker rs718314, was associated with RCC risk in the GWAS (P = 1.2 × 10−7) but did not replicate (P = 0.99). Consistent with European-ancestry findings, the A allele of rs7105934 on 11q13.3 was associated with decreased risk [OR, 0.76, 95% confidence interval (CI), 0.64–0.91; P = 0.0022]. The frequency of this allele was higher than that observed in the European-ancestry GWAS (0.56 and 0.07, respectively, among controls). The rs7105934 association was stronger for clear cell RCC (ccRCC: OR, 0.56; P = 7.4 × 10−7) and absent for cases of other or unknown histology (OR, 1.02; P = 0.86). Analyses of rs7105934 by subtype among European-ancestry participants from these studies yielded similar findings (ORs 0.69 and 0.92, respectively). This study provides, to our knowledge, the first evidence that rs7105934 is an RCC susceptibility locus among AAs. Our finding that the association with this SNP may be specific to clear-cell RCC is novel and requires additional investigation. Additional investigation of rs10771279 and other suggestive GWAS findings is also needed. Cancer Epidemiol Biomarkers Prev; 23(1); 209–14. ©2013 AACR.
Lappaol F, a Novel Anticancer Agent Isolated from PlantArctium LappaL.
Authors: Sun Qing , Liu Kanglun , Shen Xiaoling , Jin Weixin , Jiang Lingyan , Saeed Sheikh M. , Hu Yingjie , Huang Ying 
Published: November 2013

AbstractIn an effort to search for new cancer-fighting therapeutics, we identified a novel anticancer constituent, Lappaol F, from plant Arctium Lappa L. Lappaol F suppressed cancer cell growth in a time- and dose-dependent manner in human cancer cell lines of various tissue types. We found that Lappaol F induced G1 and G2 cell-cycle arrest, which was associated with strong induction of p21 and p27 and reduction of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Depletion of p21 via genetic knockout or short hairpin RNA (shRNA) approaches significantly abrogated Lappaol F–mediated G2 arrest and CDK1 and cyclin B1 suppression. These results suggest that p21 seems to play a crucial role in Lappaol F–mediated regulation of CDK1 and cyclin B1 and G2 arrest. Lappaol F–mediated p21 induction was found to occur at the mRNA level and involved p21 promoter activation. Lappaol F was also found to induce cell death in several cancer cell lines and to activate caspases. In contrast with its strong growth inhibitory effects on tumor cells, Lappaol F had minimal cytotoxic effects on nontumorigenic epithelial cells tested. Importantly, our data also demonstrate that Lappaol F exhibited strong growth inhibition of xenograft tumors in nude mice. Lappaol F was well tolerated in treated animals without significant toxicity. Taken together, our results, for the first time, demonstrate that Lappaol F exhibits antitumor activity in vitro and in vivo and has strong potential to be developed as an anticancer therapeutic. Mol Cancer Ther; 13(1); 49–59. ©2013 AACR.
Differences in the Profile, Treatment, and Prognosis of Patients With Cardiogenic Shock by Myocardial Infarction Classification
Authors: Anderson Monique L. , Peterson Eric D. , Peng S. Andrew , Wang Tracy Y. , Ohman E. Magnus , Bhatt Deepak L. , Saucedo Jorge F. , Roe Matthew T. 
Published: November 2013

Background—
Cardiogenic shock is a deadly complication of an acute myocardial infarction (MI). We sought to characterize differences in patient features, treatments, and outcomes of cardiogenic shock by MI classification: ST–segment-elevation MI (STEMI) versus non–ST-segment elevation MI (NSTEMI).

Methods and Results—

We compared differences in care by the shock status of 235 541 patients with STEMI and NSTEMI treated at 392 US hospitals from 2007 to 2011. Cardiogenic shock occurred in 12.2% of patients with STEMI versus 4.3% of patients with NSTEMI. Compared with STEMI shock, NSTEMI shock was more likely in patients who were older and predominantly women; had diabetes mellitus, hypertension, previous heart failure, MI, or peripheral arterial disease; and who received coronary artery bypass grafting (11.6% versus 21.2%;
P
<0.0001) but less likely to have received percutaneous coronary intervention (84.2% versus 35.3%;
P
<0.0001). Compared with patients with STEMI presenting with shock at admission, patients with NSTEMI presenting with shock had longer delays to percutaneous coronary intervention (1.2 versus 3.2 hours) and coronary artery bypass grafting (7.9 versus 55.9 hours). Cardiogenic shock in patients with STEMI was associated with a lower mortality risk (33.1% shock versus 2.0% no shock; adjusted odds ratio, 14.1; 95% confidence interval, 13.0–15.4; interaction
P
value <0.0001) compared with patients with NSTEMI (40.8% shock versus 2.3% no shock, odds ratio, 19.0; 95% confidence interval, 17.1–21.2).

Conclusions—
Cardiogenic shock is associated with high mortality in patients with STEMI and NSTEMI. However, urgent revascularization is more commonly pursued in patients with STEMI presenting with shock than in patients with NSTEMI. More research is needed to improve the outcomes for patients with MI presenting with shock, particularly those presenting with NSTEMI.
The YOU CALL–WE CALL Randomized Clinical Trial
Authors: Rochette Annie , Korner-Bitensky Nicol , Bishop Duane , Teasell Robert , White Carole L. , Bravo Gina , Côté Robert , Green Teri , Lebrun Louise-Hélène , Lanthier Sylvain , Kapral Moira , Bayley Mark 
Published: November 2013

Background—
Comparison of a multimodal intervention WE CALL (study initiated phone support/information provision) versus a passive intervention YOU CALL (participant can contact a resource person) in individuals with first mild stroke.

Methods and Results—
This study is a single-blinded randomized clinical trial. Primary outcome includes unplanned use of health services (participant diaries) for adverse events and quality of life (Euroquol-5D, Quality of Life Index). Secondary outcomes include planned use of health services (diaries), mood (Beck Depression Inventory II), and participation (Assessment of Life Habits [LIFE-H]). Blind assessments were done at baseline, 6, and 12 months. A mixed model approach for statistical analysis on an intention-to-treat basis was used where the group factor was intervention type and occasion factor time, with a significance level of 0.01. We enrolled 186 patients (WE=92; YOU=94) with a mean age of 62.5±12.5 years, and 42.5% were women. No significant differences were seen between groups at 6 months for any outcomes with both groups improving from baseline on all measures (effect sizes ranged from 0.25 to 0.7). The only significant change for both groups from 6 months to 1 year (n=139) was in the social domains of the LIFE-H (increment in score, 0.4/9±1.3 [95% confidence interval, 0.1–0.7]; effect size, 0.3). Qualitatively, the WE CALL intervention was perceived as reassuring, increased insight, and problem solving while decreasing anxiety. Only 6 of 94 (6.4%) YOU CALL participants availed themselves of the intervention.

Conclusions—
Although the 2 groups improved equally over time, WE CALL intervention was perceived as helpful, whereas YOU CALL intervention was not used.

Clinical Trial Registration—

URL:
http://www.controlled-trials.com
. Unique identifier: ISRCTN95662526.
Association Between Perceived Life Chaos and Medication Adherence in a Postmyocardial Infarction Population
Authors: Zullig Leah L. , Shaw Ryan J. , Crowley Matthew J. , Lindquist Jennifer , Grambow Steven C. , Peterson Eric , Shah Bimal R. , Bosworth Hayden B. 
Published: November 2013

Background—
The benefits of medication adherence to control cardiovascular disease (CVD) are well defined, yet multiple studies have identified poor adherence. The influence of life chaos on medication adherence is unknown. Because this is a novel application of an instrument, our preliminary objective was to understand patient factors associated with chaos. The main objective was to evaluate the extent to which an instrument designed to measure life chaos is associated with CVD-medication nonadherence.

Methods and Results—
Using baseline data from an ongoing randomized trial to improve postmyocardial infarction (MI) management, multivariable logistic regression identified the association between life chaos and CVD-medication nonadherence. Patients had hypertension and a myocardial infarction in the past 3 years (n=406). Nearly 43% reported CVD-medication nonadherence in the past month. In simple linear regression, the following were associated with higher life chaos: medication nonadherence (β=1.86; 95% confidence interval [CI], 0.96–2.76), female sex (β=1.22; 95% CI [0.22–2.24]), minority race (β=1.72; 95% CI [0.78–2.66]), having less than high school education (β=2.05; 95% CI [0.71–3.39]), low health literacy (β=2.06; 95% CI [0.86–3.26]), and inadequate financial status (β=1.93; 95% CI [0.87–3.00]). Being married (β=−2.09, 95% CI [−3.03 to −1.15]) was associated with lower life chaos. As chaos quartile increased, patients exhibited more nonadherence. In logistic regression, adjusting for sex, race, marital status, employment, education, health literacy, and financial status, a 1-unit life chaos increase was associated with a 7% increase (odds ratio, 1.07; 95% CI [1.02–1.12]) in odds of reporting medication nonadherence.

Conclusions—
Our results suggest that life chaos may be an important determinant of medication adherence. Life chaos screenings could identify those at risk for nonadherence.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT000901277
The China Patient-Centered Evaluative Assessment of Cardiac Events (China PEACE) Retrospective Study of Acute Myocardial Infarction: Study Design
Authors: Dharmarajan Kumar , Li Jing , Li Xi , Lin Zhenqiu , Krumholz Harlan M. , Jiang Lixin 
Published: November 2013

Background—
Cardiovascular diseases are rising as a cause of death and disability in China. To improve outcomes for patients with these conditions, the Chinese government, academic researchers, clinicians, and >200 hospitals have created China Patient-Centered Evaluative Assessment of Cardiac Events (China PEACE), a national network for research and performance improvement. The first study from China PEACE, the Retrospective Study of Acute Myocardial Infarction (China PEACE-Retrospective AMI Study), is designed to promote improvements in acute myocardial infarction (AMI) quality of care by generating knowledge about the characteristics, treatments, and outcomes of patients hospitalized with AMI across a representative sample of Chinese hospitals during the past decade.

Methods and Results—
The China PEACE-Retrospective AMI Study will examine >18 000 patient records from 162 hospitals identified using a 2-stage cluster sampling design within economic–geographic regions. Records were chosen from 2001, 2006, and 2011 to identify temporal trends. Data quality will be monitored by a central coordinating center and will, in particular, address case ascertainment, data abstraction, and data management. Analyses will examine patient characteristics, diagnostic testing patterns, in-hospital treatments, in-hospital outcomes, and variation in results by time and site of care. In addition to publications, data will be shared with participating hospitals and the Chinese government to develop strategies to promote quality improvement.

Conclusions—
The China PEACE-Retrospective AMI Study is the first to leverage the China PEACE platform to better understand AMI across representative sites of care and during the past decade in China. The China PEACE collaboration among government, academicians, clinicians, and hospitals is poised to translate research about trends and patterns of AMI practices and outcomes into improved care for patients.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01624883.
Formation and Function of Acute Stroke–Ready Hospitals Within a Stroke System of Care Recommendations From the Brain Attack Coalition
Authors: Alberts Mark J. , Wechsler Lawrence R. , Jensen Mary E. Lee , Latchaw Richard E. , Crocco Todd J. , George Mary G. , Baranski James , Bass Robert R. , Ruff Robert L. , Huang Judy , Mancini Barbara , Gregory Tammy , Gress Daryl , Emr Marian , Warren Margo , Walker Michael D. 
Published: November 2013

Background and Purpose—
Many patients with an acute stroke live in areas without ready access to a Primary or Comprehensive Stroke Center. The formation of care facilities that meet the needs of these patients might improve their care and outcomes and guide them and emergency responders to such centers within a stroke system of care.

Methods—
The Brain Attack Coalition conducted an electronic search of the English medical literature from January 2000 to December 2012 to identify care elements and processes shown to be beneficial for acute stroke care. We used evidence grading and consensus paradigms to synthesize recommendations for Acute Stroke–Ready Hospitals (ASRHs).

Results—
Several key elements for an ASRH were identified, including acute stroke teams, written care protocols, involvement of emergency medical services and emergency department, and rapid laboratory and neuroimaging testing. Unique aspects include the use of telemedicine, hospital transfer protocols, and drip and ship therapies. Emergent therapies include the use of intravenous tissue-type plasminogen activator and the reversal of coagulopathies. Although many of the care elements are similar to those of a Primary Stroke Center, compliance rates of ≥67% are suggested in recognition of the staffing, logistical, and financial challenges faced by rural facilities.

Conclusions—
ASRHs will form the foundation for acute stroke care in many settings. Recommended elements of an ASRH build on those proven to improve care and outcomes at Primary Stroke Centers. The ASRH will be a key component for patient care within an evolving stroke system of care.
Loss of Mural Cells Leads to Wall Degeneration, Aneurysm Growth, and Eventual Rupture in a Rat Aneurysm Model
Authors: Marbacher Serge , Marjamaa Johan , Bradacova Katerina , von Gunten Michael , Honkanen Petri , Abo-Ramadan Usama , Hernesniemi Juha , Niemelä Mika , Frösen Juhana 
Published: November 2013

Background and Purpose—
The biological mechanisms predisposing intracranial saccular aneurysms to growth and rupture are not yet fully understood. Mural cell loss is a histological hallmark of ruptured cerebral aneurysms. It remains unclear whether mural cell loss predisposes to aneurysm growth and eventual rupture.

Methods—
Sodium dodecyl sulfate decellularized and nondecellularized saccular aneurysm from syngeneic thoracic aortas were transplanted to the abdominal aorta of Wistar rats. Aneurysm patency and growth was followed up for 1 month with contrast-enhanced serial magnetic resonance angiographies. Endoscopy and histology of the aneurysms were used to assess the role of periadventitial environment, aneurysm wall, and thrombus remodeling.

Results—
Nondecellularized aneurysms (n=12) showed a linear course of thrombosis and remained stable. Decellularized aneurysms (n=12) exhibited a heterogeneous pattern of thrombosis, thrombus recanalization, and growth. Three of the growing aneurysms (n=5) ruptured during the observation period. Growing and ruptured aneurysms demonstrated marked adventitial fibrosis and inflammation, complete wall disruption, and increased neutrophil accumulation in unorganized intraluminal thrombus.

Conclusions—
In the presented experimental setting, complete loss of mural cells acts as a driving force for aneurysm growth and rupture. The findings suggest that aneurysms missing mural cells are incapable to organize a luminal thrombus, leading to recanalization, increased inflammatory reaction, severe wall degeneration, and eventual rupture.
Integral Constraints for Momentum and Energy in Zonal Flows with Parameterized Potential Vorticity Fluxes: Governing Parameters
Authors: Ivchenko V. O. , Danilov S. , Sinha B. , Schröter J. 
Published: November 2013

Abstract
Integral constraints for momentum and energy impose restrictions on parameterizations of eddy potential vorticity (PV) fluxes. The impact of these constraints is studied for a wind-forced quasigeostrophic two-layer zonal channel model with variable bottom topography. The presence of a small parameter, given by the ratio of Rossby radius to the width of the channel, makes it possible to find an analytical/asymptotic solution for the zonally and time-averaged flow, given diffusive parameterizations for the eddy PV fluxes. This solution, when substituted in the constraints, leads to nontrivial explicit restrictions on diffusivities. The system is characterized by four dimensionless governing parameters with a clear physical interpretation. The bottom form stress, the major term balancing the external force of wind stress, depends on the governing parameters and fundamentally modifies the restrictions compared to the flat bottom case. While the analytical solution bears an illustrative character, it helps to see certain nontrivial connections in the system that will be useful in the analysis of more complicated models of ocean circulation. A numerical solution supports the analytical study and confirms that the presence of topography strongly modifies the eddy fluxes.
Summer Precipitation Events over the Western Slope of the Subtropical Andes
Authors: Viale Maximiliano , Garreaud René 
Published: November 2013

AbstractSummertime [December–February (DJF)] precipitation over the western slopes of the subtropical Andes (32°–36°S) accounts for less than 10% of the annual accumulation, but it mostly occurs as rain and may trigger landslides leading to serious damages. Based on 13 year of reanalysis, in situ observations, and satellite imagery, a synoptic climatology and physical diagnosis reveal two main weather types lead to distinct precipitation systems. The most frequent type (~80% of the cases) occurs when a short-wave midlevel trough with weak winds and thermally driven mountain winds favor the development of convective precipitation during the daytime. The trough progresses northwest of a long-lasting warm ridge, which produces low-level easterly airflow that enhances its buoyancy as it moves over the arid land of western Argentina toward the Andes. The weak winds aloft facilitate the penetration of the moist easterly flow into the Andes. Midlevel flow coming from the west side of the Andes is decoupled from the low-level maritime air by a temperature inversion, and thus provides little moisture to support precipitation. The less frequent type (~20% of the cases) occurs when a deep midlevel trough and strong westerly flow produces stratiform precipitation. This type has a baroclinic nature akin to winter storms, except that they are rare in summer and there is no evidence of a frontal passage at low levels. The lifting and cooling ahead of the trough erode the typical temperature inversion over the Pacific coast, and thus allows upslope transport of low-level marine air by the strong westerlies forming a precipitating cloud cap on the western slope of the Andes.
Transnational Migration, Customary Governance, and the Future of Community
Authors: Robson James P. , Wiest Raymond 
Published: November 2013

Common-property regimes owned and governed by predominantly indigenous communities are widespread in the Mexican state of Oaxaca. The traditional governance systems of these communities are under strain because of transnational migration, which reduces the number of resident adults available to assume public offices and contribute labor to community projects. A study of responses to this situation in two such communities identified adaptations including the establishment of hometown associations in migrant communities in the United States and the requirement that migrants hire substitutes to fulfill their obligations in the home community. Given shifts in migration patterns and migrant profiles, however, these adaptations have so far been insufficient to relieve the stress on governance institutions, and this has implications for community identity and governance in the future. Regímenes de propiedad comunitaria en donde los propietarios y gobernantes son las comunidades indígenas son comunes en el estado mexicano de Oaxaca. En la actualidad las estructuras tradicionales de gobernación de estas comunidades sufren bajo la tensión causada por la migración trasnacional, la cual reduce el número de residentes adultos disponibles para asumir cargos públicos y prestar mano de obra para proyectos de la comunidad. Un estudio de las respuestas a esta situación en dos de esas comunidades identificó adaptaciones que incluyen el establecimiento de asociaciones de tierra de origen en las comunidades de migrantes en los Estados Unidos y el requerimiento de contratar a suplentes que cumplan las obligaciones de los migrantes en sus comunidades de origen. Sin embargo, dados los cambios en el modelo migratorio y el perfil del migrante, estas adaptaciones han sido hasta el momento insuficientes para aliviar la tensión en las instituciones de gobierno, lo cual tiene implicaciones para el futuro de la identidad y gobernación comunitarias.