bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neck recurrence of oral squamous cell carcinoma in unusual sites: Retrospective study of 1658 cases
Authors: Feng Zhien , Niu Li Xuan , Zhang Jian Yun , Gao Yan , Guo Chuan Bin 
Published: April 2015

ABSTRACTBackgroundThe purpose of this study was to explore the frequency and prognosis of irregular neck recurrences in the prelaryngeal, parotid, and lateral retropharyngeal regions in patients with oral squamous cell carcinoma (OSCC).MethodsWe conducted a retrospective study.ResultsTwenty‐four patients (1.4%) had irregular neck recurrences: 17 in the parotid (1.0%), 4 in the prelaryngeal (0.2%), and 3 in the lateral retropharyngeal (0.2%) regions. The 1‐year/5‐year overall survival rates after the N‐relapse date for these areas were 40.0%/25.0%, 42.9%/20.0%, and 33.3%/0%, respectively. Patients with irregular neck recurrences had a poorer salvage success rate than controls (21.7% vs 68.8%, respectively; p < .001) as well as a significantly lower 5‐year disease‐specific survival (23.8% vs 60.8%, respectively; p < .001).ConclusionPatients with OSCC with irregular neck recurrences were extremely rare and had poor prognoses. The management of irregular metastases in patients with OSCC remains challenging for surgeons. Further study will be worthwhile to evaluate the best diagnostic and management strategies for unusual neck recurrences of OSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E680–E686, 2016
Genetic polymorphisms in UDP‐glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland
Authors: Lacko Martin , Voogd Adri C. , van de Goor Rens C.E. , Roelofs Hennie M.J. , te Morsche Rene H.M. , Bouvy Nicole D. , Peters Wilbert H.M. , Manni Johannes J. 
Published: April 2015

AbstractBackgroundWarthin's tumors of the parotid gland are associated with smoking, whereas pleomorphic adenomas are not. Genetic polymorphisms in biotransformation enzymes, involved in detoxification of toxins and carcinogens in cigarette smoke, might modify the corresponding enzyme activity and influence detoxifying capacity. We hypothesize that these genetic polymorphisms may influence the individual risk for Warthin's tumor, but not for pleomorphic adenomas.MethodsBlood from 146 patients with benign parotid gland tumors and 437 controls were investigated for polymorphisms in several biotransformation enzymes. Based on these polymorphisms, patients and controls were divided according to predicted enzyme activity (low, intermediate, and high).ResultsPrevalence of predicted intermediate and high activity UGT1A7 and UGT1A6 genotypes was significantly higher in the patients with Warthin's tumors, but not in patients with pleomorphic adenomas, compared with healthy controls.ConclusionPredicted intermediate and high activity UGT1A7 and UGT1A6 genotypes are associated with an increased risk for Warthin's tumor. © 2015 Wiley Periodicals, Inc. Head Neck 38: E717–E723, 2016
Intraoral sebaceous carcinoma metastatic to the lung and subcutis: Case report and discussion of the literature
Authors: Rowe Meghan E. , Khorsandi Azita S. , Urken Grant R. , Wenig Bruce M. 
Published: April 2015

AbstractBackgroundIntraoral sebaceous carcinoma is a rare form of sebaceous carcinoma with only 9 published cases in the world literature to date. We present a 10th case of intraoral sebaceous carcinoma located in the anterior maxillary gingiva with metastases to the lung and subcutis and discuss 3 possible etiologies for this unique presentation.MethodsWe analyze the clinical presentation, pathology, histology, and genetic testing for a single case study and review relevant literature.ResultsThe histologic findings of the lung tumor and surgical excisions of the tumors in the gingiva and subcutis suggest the gingiva is the primary site. There is no evidence for the genetic abnormalities consistent with Muir–Torre syndrome.ConclusionThe histologic findings suggest the oral cavity is the most likely site of tumor origin. This is the first case of intraoral sebaceous carcinoma reported to arise in the gingiva as well as to spread to cutaneous sites. © 2015 Wiley Periodicals, Inc. Head Neck 38: E20–E24, 2016
Dissociation of MIF‐rpS3 Complex and Sequential NF‐κB Activation Is Involved in IR‐Induced Metastatic Conversion of NSCLC
Authors: Youn HyeSook , Son Beomseok , Kim Wanyeon , Jun Se Young , Lee Jung Sub , Lee Jae‐Myung , Kang ChulHee , Kim Joon , Youn BuHyun 
Published: April 2015

ABSTRACTFrequent relapse and spreading of tumors during radiotherapy are principal obstacles to treatment of non‐small cell lung cancer (NSCLC). In this study, we aimed to investigate how macrophage migration inhibitory factor (MIF) which is expressed at high levels in metastatic and primary lung cancer cells could regulate NSCLC metastasis in response to ionizing radiation (IR). The results indicated that MIF and ribosomal protein S3 (rpS3) were shown to be connected to inflammation, proliferation, and metastasis of NSCLC via IR‐induced activation of the NF‐κB pathway. Under unirradiated conditions, MIF physically established a complex with rpS3. MIF‐rpS3 dissociation induced by IR activated NF‐κB and made the expression of target genes of this factor transactivated in two NSCLC cell lines, A549, and NCI‐H358. We also found that IR‐induced dissociation of this complex led to increased secretion of pro‐inflammatory cytokines and modulated the expression of epithelial–mesenchymal transition marker proteins. Finally, the effects of IR‐induced dissociation of the MIF‐rpS3 complex on tumor metastasis were confirmed by in vivo xenograft studies. Taken together, the present study revealed that dissociation of the MIF‐rpS3 complex and subsequent activation of NF‐κB is a critical post‐IR exposure event that accounts for IR‐induced metastatic conversion of NSCLC. J. Cell. Biochem. 116: 2504–2516, 2015. © 2015 Wiley Periodicals, Inc.
An Investigation of Depression, Trauma History, and Symptom Severity in Individuals Enrolled in a Treatment Trial for Chronic PTSD
Authors: Bedard‐Gilligan Michele , Duax Jakob Jeanne M. , Doane Lisa Stines , Jaeger Jeff , Eftekhari Afsoon , Feeny Norah , Zoellner Lori A. 
Published: April 2015

ObjectiveTo explore how factors such as major depressive disorder (MDD) and trauma history, including the presence of childhood abuse, influence diverse clinical outcomes such as severity and functioning in a sample with posttraumatic stress disorder (PTSD).MethodIn this study, 200 men and women seeking treatment for chronic PTSD in a clinical trial were assessed for trauma history and MDD and compared on symptom severity, psychosocial functioning, dissociation, treatment history, and extent of diagnostic co‐occurrence.ResultsOverall, childhood abuse did not consistently predict clinical severity. However, co‐occurring MDD, and to a lesser extent a high level of trauma exposure, did predict greater severity, worse functioning, greater dissociation, more extensive treatment history, and additional co‐occurring disorders.ConclusionThese findings suggest that presence of co‐occurring depression may be a more critical marker of severity and impairment than history of childhood abuse or repeated trauma exposure. Furthermore, they emphasize the importance of assessing MDD and its effect on treatment seeking and treatment response for those with PTSD.
GaN Ku‐band low‐noise amplifier design including RF life test
Authors: D'Angelo Sara , Nalli Andrea , Resca Davide , Raffo Antonio , Florian Corrado , Scappaviva Francesco , Vannini Giorgio , Rochette Stephane , Muraro Jean‐Luc 
Published: April 2015

AbstractAs well as largely exploited for microwave high‐power applications, aluminum gallium nitride (AlGaN)/GaN high electron mobility transistor (HEMT) technologies have demonstrated promising results for the design of low‐noise, high dynamic range, and highly robust amplifiers. In this manuscript, we describe the design and characterization of a Ku‐band monolithic microwave integrated circuit low‐noise amplifier for telecom space applications, exploiting an industrial AlGaN/GaN 0.25‐µm HEMT on silicon carbide process. In the frequency band 12.75–14.8 GHz, the LNA features over 20 dB linear gain with a noise figure around 1.8 dB. Input and output return losses are nearly 10 dB. Power dissipation is 700 mW in linear operation. An innovative transistor model based on electromagnetic analyses and small‐signal and noise measurements has been developed to improve the predictions of the foundry model on source‐degenerated devices. A systematic radio frequency (RF) life stress test campaign performed on the designed low‐noise amplifier demonstrated a safe operating area of 15 dBm of overdrive input power. Copyright © 2015 John Wiley & Sons, Ltd.
Primary cutaneous and subcutaneous Ewing sarcoma
Authors: Di Giannatale Angela , Frezza Anna Maria , Le Deley Marie‐Cécile , Marec‐Bérard Perrine , Benson Charlotte , Blay Jean‐Yves , Bui Binh , Judson Ian , Oberlin Odile , Whelan Jeremy , Gaspar Nathalie 
Published: April 2015

BackgroundPrimary cutaneous/subcutaneous Ewing sarcoma (scEWS) is extremely rare. We describe clinical features, treatment, and outcome of this Ewing localization.ProcedureRetrospective study (1996–2012) on 56 patients.ResultsMost primary scEWS occurred in late adolescent/young adult females (F/M = 1.9; median age 21.5 years), with primary tumor in the extremity/trunk (48.5%/39%). Only 35/56 samples had Real‐Time‐Polymerase‐Chain‐Reaction/Fluorescent‐In‐Situ‐Hybridization analysis, 32/35 had EWS‐translocation. Most of them exhibited known favorable prognostic factors: localized disease (54/56), initial tumor volume < 200 ml (51/53). Thirty and 25 patients received chemotherapy according to Euro‐Ewing99 or a shorter/less intense chemotherapy regimen associated with milder toxicity. One patient had not received chemotherapy. Surgery was performed at diagnosis in 37 patients (18/37 marginal/intra‐lesional resections) followed by secondary surgery in 8/37 (three remained marginal). Nineteen other patients had an initial biopsy followed by chemotherapy, 15/19 underwent late surgery (4/15 marginal/intra‐lesional resections). Overall, 27/56 patients received radiotherapy. Median follow‐up was six years (1–15). Two patients with metastatic disease progressed at metastatic sites. Four patients with localized disease experienced progression/relapse (local n = 3, metastatic n = 1). Survival was excellent: 5y‐OS and 5y‐EFS were 93.8% (95%CI = 83–98%) and 88.5% (95%CI–= 77–95), respectively.ConclusionsUnplanned primary surgery should be avoided to try to minimize potential long term sequels due to secondary surgery or radiotherapy. Biopsy with molecular analysis and staging should be performed at diagnosis to inform treatment recommendations. Patients with metastases should be treated aggressively as for other metastatic EWS. Further studies are necessary to clarify whether a less intensive chemotherapy regimen could be safely used in localized disease to minimize acute/late toxicities. Pediatr Blood Cancer 2015;62:1555–1561. © 2015 Wiley Periodicals, Inc.
Medical and sociodemographic factors associated with human papillomavirus (HPV) vaccination adherence among female survivors of childhood cancer
Authors: Klosky James L. , Russell Kathryn M. , Simmons Jessica L. , Foster Rebecca H. , Peck Kelly , Green Daniel M. , Hudson Melissa M. 
Published: April 2015

BackgroundAmong those 9–26 years of age, vaccination can prevent specific types of genital human papillomavirus (HPV), the most common sexually transmitted infection and cause of cervical and other cancers. The objective of this study was to estimate the prevalence of and factors associated with HPV vaccine initiation and completion among females surviving childhood cancer.ProcedureOne‐hundred fourteen young adults and 230 mothers with daughters surviving childhood cancer completed surveys querying HPV vaccination history along with medical and sociodemographic factors potentially associated with vaccination outcomes. Vaccination rate differences by age necessitated analysis of outcomes by age group: 9–13 years (preadolescents), 14–17 years (adolescents), and 18–26 years (young adults). Multivariable logistic regression was utilized to identify factors associated with HPV vaccination outcomes.ResultsOverall, 34.6% (119/344) of survivors initiated and 20.9% (72/344) completed HPV vaccination. Preadolescents were least likely to have initiated vaccination (P < 0.001). Physician recommendation was associated with initiation across age groups (OR = 6.81–11.96, Ps < 0.001–.01), whereas older age at diagnosis (≥12 years of age) was associated with lower vaccination initiation among young adults only (OR = 0.28; 95%CI, 0.10–0.76, P = 0.012). Physician recommendation (OR = 7.54; 95%CI, 1.19–47.69, P = 0.032; adolescent group) and greater treatment intensity (OR = 5.25; 95%CI, 1.00–27.61, P = 0.050; young adult group) were associated with vaccine completion, whereas being non‐White was associated with decreased vaccination completion (OR = 0.17; 95%CI, 0.05–0.66, P = 0.010; adolescent group).ConclusionsA minority of youths surviving childhood cancer have initiated or completed HPV vaccination. Strategies to increase vaccination among survivors are discussed. Pediatr Blood Cancer 2015;62:1630–1636. © 2015 Wiley Periodicals, Inc.
Long‐term renal function in unilateral non‐syndromic renal tumor survivors treated according to International Society of Pediatric Oncology protocols
Authors: Schiavetti Amalia , Altavista Pierluigi , De Luca Laura , Andreoli Gianmarco , Megaro Giacomina , Versacci Paolo 
Published: April 2015

BackgroundThe risk of renal impairment among survivors of childhood unilateral non‐syndromic renal tumors (RTs) is not well defined. We evaluated the prevalence of and possible risk factors for renal impairment by estimating Glomerular Filtration Rate (eGFR) categories and chronic kidney disease (CKD) according to Kidney Disease: Improving Global Outcomes guidelines.ProcedureSince 1978, 82 patients were treated for RT, according to the International Society of Pediatric Oncology protocols in a single oncology unit. Of the 67 survivors, those who underwent nephron sparing surgery, those with short‐term follow‐up or those who had bilateral and/or syndromic disease or a second malignancy were excluded. Thirty‐five adult survivors (14 M/21F; mean age 25 years; mean follow‐up 20 years) were studied by chemistry, kidney ultrasound, blood pressure measurement, urinanalysis. Correlations were investigated between the prevalence of eGFR categories and CKD and gender, age at diagnosis, radiotherapy, chemotherapy, body mass index, time of follow‐up, and age at study.ResultsEight (22.9%) survivors presented a mildly decreased eGFR (G2 category), the mean value was 80 ± 9.78 ml/min/1.73m2 (median 84.5, range 63–89). Three (8.6%) survivors had CKD and a fourth (2.9%) hypertension. No significant correlations between G2 category and clinical variables were found.ConclusionsA small percentage of survivors had CKD or hypertension after two decades. It is not yet clear whether a mildly decreased eGFR that does not constitute CKD in the absence of other markers (albuminuria and/or kidney ultrasound abnormalities) is likely to progress to CKD. Health promotion programs to avoid comorbidities are required. Pediatr Blood Cancer 2015;62:1637–1644. © 2015 Wiley Periodicals, Inc.
Sunitinib reduces tumor hypoxia and angiogenesis, and radiosensitizes prostate cancer stem‐like cells
Authors: Diaz Roque , Nguewa Paul A. , Redrado Miriam , Manrique Irene , Calvo Alfonso 
Published: April 2015

INTRODUCTIONThe need for new treatments for advanced prostate cancer has fostered the experimental use of targeted therapies. Sunitinib is a multi‐tyrosine kinase inhibitor that mainly targets membrane‐bound receptors of cells within the tumor microenvironment, such as endothelial cells and pericytes. However, recent studies suggest a direct effect on tumor cells. In the present study, we have evaluated both direct and indirect effects of Sunitinib in prostate cancer and how this drug regulates hypoxia, using in vitro and in vivo models.METHODSWe have used both in vitro (PC‐3, DU145, and LNCaP cells) and in vivo (PC‐3 xenografts) models to study the effect of Sunitinib in prostate cancer. Analysis of hypoxia based on HIF‐1α expression and FMISO uptake was conducted. ALDH activity was used to analyze cancer stem cells (CSC).RESULTSSunitinib strongly reduced proliferation of PC‐3 and DU‐145 cells in a dose dependent manner, and decreased levels of p‐Akt, p‐Erk1/2, and Id‐1, compared to untreated cells. A 3‐fold reduction in tumor growth was also observed (P < 0.001 with respect to controls). Depletion of Hif‐1α levels in vitro and a decrease in FMISO uptake in vivo showed that Sunitinib inhibits tumor hypoxia. When combined with radiotherapy, this drug enhanced cell death in vitro and in vivo, and significantly decreased CD‐31, PDGFRβ, Hif‐1α, Id1, and PCNA protein levels (whereas apoptosis was increased) in tumors as compared to controls or single‐therapy treated mice. Moreover, Sunitinib reduced the number of ALDH + cancer stem‐like cells and sensitized these cells to radiation‐mediated loss of clonogenicity.DISCUSIONOur results support the use of Sunitinib in prostate cancer and shows that both hypoxia and cancer stem cells are involved in the effect elicited by this drug. Combination of Sunitinib with radiotherapy warrants further consideration to reduce prostate cancer burden. Prostate 75: 1137–1149, 2015. © 2015 Wiley Periodicals, Inc.
The 21st Annual Prostate Cancer Foundation Scientific Retreat report
Authors: Miyahira Andrea K. , Simons Jonathan W. , Soule Howard R. 
Published: April 2015

AbstractThe 21st Annual Prostate Cancer Foundation (PCF) Scientific Retreat was held from October 23‐25, 2014, in Carlsbad, CA. This event is the world's foremost scientific meeting focusing on prostate cancer and brings together leading basic, translational and clinical researchers in prostate cancer and other diverse disciplines to discuss the newest findings most likely to advance the understanding of prostate cancer and the clinical care of prostate cancer patients. This year's meeting highlighted themes including: (i) research integrity and standards for scientific reproducibility; (ii) prostate cancer disparities; (iii) mechanisms and models of prostate cancer progression and dormancy; (iv) mechanisms of therapeutic resistance; and (v) advancements in precision medicine treatments, treatment models, and predictive and prognostic biomarkers. Prostate 75: 1119–1128, 2015. © 2015 Wiley Periodicals, Inc.
Prostate stromal cell telomere shortening is associated with risk of prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial
Authors: Heaphy Christopher M. , Gaonkar Gaurav , Peskoe Sarah B. , Joshu Corinne E. , De Marzo Angelo M. , Lucia M. Scott , Goodman Phyllis J. , Lippman Scott M. , Thompson Ian M. , Platz Elizabeth A. , Meeker Alan K. 
Published: April 2015

BackgroundTelomeres are repetitive nucleoproteins that help maintain chromosomal stability by inhibiting exonucleolytic degradation, prohibiting inappropriate homologous recombination, and preventing chromosomal fusions by suppressing double‐strand break signals. We recently observed that men treated for clinically localized prostate cancer with shorter telomeres in their cancer‐associated stromal cells, in combination with greater variation in cancer cell telomere lengths, were significantly more likely to progress to distant metastases, and die from their disease. Here, we hypothesized that shorter stromal cell telomere length would be associated with prostate cancer risk at time of biopsy.MethodsTelomere‐specific fluorescence in situ hybridization (FISH) analysis was performed in normal‐appearing stromal, basal epithelial, and luminal epithelial cells in biopsies from men randomized to the placebo arm of the Prostate Cancer Prevention Trial. Prostate cancer cases (N = 32) were either detected on a biopsy performed for cause or at the end of the study per trial protocol, and controls (N = 50), defined as negative for cancer on an end‐of‐study biopsy performed per trial protocol (e.g., irrespective of indication), were sampled. Logistic regression was used to estimate the association between mean telomere length of the particular cell populations, cell‐to‐cell telomere length variability, and risk of prostate cancer.ResultsMen with short stromal cell telomere lengths (below median) had 2.66 (95% CI 1.04–3.06; P = 0.04) times the odds of prostate cancer compared with men who had longer lengths (at or above median). Conversely, we did not observe statistically significant associations for short telomere lengths in normal‐appearing basal (OR = 2.15, 95% CI 0.86–5.39; P= 0 .10) or luminal (OR = 1.15, 95% CI 0.47–2.80; P = 0.77) cells.ConclusionsThese findings suggest that telomere shortening in normal stromal cells is associated with prostate cancer risk. It is essential to extend and validate these findings, while also identifying the cellular milieu that comprises the subset of cells with short telomeres within the prostate tumor microenvironment. Prostate 75: 1160–1166, 2015. © 2015 Wiley Periodicals, Inc.
A Simple Method of Liver Retraction for Various Types of Laparoscopic Upper Gastrointestinal Surgeries: The Prolene Hanging‐Up Method
Authors: Lee Jeong‐Sun , Kim Jin‐Jo , Park Seung‐Man 
Published: April 2015

AbstractThis study describes a safe and the simple method for liver retraction during various types of laparoscopic upper gastrointestinal surgeries. The technique was performed using only a 75 cm 2–0 prolene suture, which was passed through the abdominal wall with a straight needle at the two points of the epigastrium and at the pars condensa of the gastrohepatic ligament without any protective material or knotting. Seventy‐six patients who underwent various types of laparoscopic upper gastrointestinal surgeries from August, 2012 to March, 2013 at Incheon St. Mary’s Hospital were included in the study. The mean time for the liver retraction was 2.7 ± 0.6 min. Among the 76 cases, complication of this method was one case of the puncture site bleeding on the abdominal wall. The mean levels of alanine aminotransferase and aspartate aminotransferase on the day of the surgery were 54.9 ± 26.3 U/L and 45.2 ± 23.1 U/L, respectively, and these had decreased to 22.4 ± 13.2 U/L and 21.8 ± 14.0 U/L, respectively, on the fourth postoperative day. The prolene hanging‐up method is very simple and safe, and it can be used in various types of laparoscopic upper gastrointestinal surgeries.