bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concept analysis of health research translation nomenclature
Authors: Lizarondo Lucylynn , Jordan Zoe , Linedale Ecushla , Lockwood Craig 
Published: February 2025

IntroductionTranslating health research into clinical practice is a complex process aimed at enhancing healthcare quality and patient outcomes. The terminology surrounding this process is varied and often used interchangeably, leading to minimal consensus on the activities encompassed by each term.ObjectivesThis study aims to examine existing taxonomies and websites for operational definitions related to health research translation, culminating in a comprehensive synopsis of terms specific to this field.DesignIn 2019, a literature search was conducted using databases such as PubMed and CINAHL, along with relevant government and non-governmental organisation (NGO) websites, including grey literature. The search focused on English-language publications defining health research translation from 2000 onward and was updated in 2023. One author conducted the search, employing a mix of free-text and database-specific terms. Two authors independently evaluated the results for inclusion. Relevant data were extracted to aid in sorting and prioritising terminology based on frequency. A concept analysis approach, developed by Foley and Davis and informed by Rodgers’ seven phases, was used to map the nomenclature.ResultsA total of 51 papers were analysed, revealing that the most frequently used terms for health research translation were knowledge translation (KT), implementation and translational research. Both evidence-based healthcare and KT describe the process of integrating evidence into practice, positioning them as analogous. Two major domains were identified: practice and science, with practice-related language further categorised into people-focused, process-focused and outcome-focused.ConclusionsThis paper presents a conceptual nomenclature map that serves as a foundation for developing a consensus-driven ontology for health research translation. The framework highlights how language can be categorised into common domains, fostering meaningful communication across diverse groups and entities.
Admission temperature in very preterm infants 2012–2021: a Nationwide Quality Registry Study, Norway
Authors: Solvang Thale Amalie Westre , Herstad Vilde Bråten , Størdal Ketil , Tveiten Lars , Lang Astri , Eriksen Beate Horsberg , Rønnestad Arild , Stensvold Hans Jørgen 
Published: February 2025

ObjectiveTo examine the distribution and time trends of admission temperature in very preterm infants, effects of temperature-preserving interventions and associations between hypothermia and outcomes.MethodsPopulation-based cohort study of infants <32 gestational weeks without lethal malformations admitted to a neonatal intensive care unit within 2 hours of birth between 1 January 2012 and 31 December 2021. Hypothermia was defined as mild (36.0°C–36.4°C), moderate (34.5°C–35.9°C) or severe (<34.5°C). Associations between admission temperature and outcomes were investigated using multivariate logistic regression, adjusting for sex, weight Z-score, gestational age, antenatal steroids, surfactant and hospital.ResultsIn total, 2457/4879 (50.4%) had normal admission temperatures between 36.5°C and 37.5℃, 1314 (26.9%) had mild hypothermia and 886 (18.2%) had moderate to severe hypothermia, with a significant interhospital variance of 7%–40%. Moderate to severe hypothermia decreased from 24% in 2012 to 16% in 2021 (ptrend<0.001). Measuring temperature before leaving the delivery unit correlated with lower incidence of moderate to severe hypothermia (42% vs 58%, p<0.001). Admission temperature was inversely associated with mortality (adjusted OR 1.5, 95% CI 1.1 to 2.0 for moderate and 2.4, 95% CI 1.1 to 4.9 for severe hypothermia) and with surgical necrotising enterocolitis or intestinal perforation (adjusted OR 1.7, 95% CI 1.1 to 2.7 for moderate and 3.1, 95% CI 1.3 to 7.7 for severe hypothermia).ConclusionsAlthough the incidence of hypothermia decreased during the study period, it remains a concern due to significant associations with adverse outcomes. Areas for further improvement include addressing interhospital variance and enhancing temperature monitoring in the delivery unit.
Efficacy of oral tetra-arsenic tetra-sulfide maintenance therapy for ovarian cancer: a single-center observational study
Authors: Yang Yingchao , Li Xiaoping , Song Xuelian , Zhao Lijun , Wang Yue , Wu Yan , Wei Lihui 
Published: February 2025

ObjectiveTo investigate firstly Chinese patent medicine Realgar-Indigo Naturalis Formula (RIF), which mainly contains tetra-arsenic tetra-sulfide formula for the maintenance therapy of ovarian cancer.MethodsWe recruited all patients with ovarian epithelial cancer who were diagnosed at Peking University People’s Hospital between January 2018 and January 2021. All these patients received standard chemotherapy and achieved complete remission. The patients took RIF (60 mg/kg daily in an oral divided dose) in a 4-week-on and 4-week-off regimen. The main efficacy indicators, including progression-free interval (PFI) and overall survival (OS), were measured and evaluated regularly. Additionally, the safety and side effects were closely monitored.ResultsA total of 20 patients were included in this study. Regarding the treatment, patients received oral arsenic for 3–18 courses (the longest treatment interval was equivalent to 3 years). The median follow-up time was 43 months. Subsequently, data analysis was conducted, revealing that the median PFI was 23 months.P53mutations were worse thanP53wild-type PFI, and the median PFI was 19.2 months (p=0.03). RegardingP53wt status, the HR for disease progression or death was 0.25 (95% CI 0.07 to 0.91). The 3-year OS was 89%, and the 5-year OS was 77%. The common side effects were abdominal pain and diarrhoea.ConclusionsRIF compound proved to be an effective Chinese patent medicine maintenance therapy for ovarian cancer, thus prolonging the PFI of patients and controllable side effects, in particular simple and convenient for the method of administration and better potency ratio. These findings need to be validated in multicentre research studies with large sample sizes.Trial registration numberChiCTR2400090349.
Revolutionizing Patient Reported Outcomes Analysis for Oncology Drug Development Using Population Models
Authors: Zhou Jiawei , Muluneh Benyam , Li Quefeng , Hughes Jim H. 
Published: February 2025

Abstract
Patient reported outcome (PRO) plays a crucial role as clinical endpoint in oncology trials. Traditional statistical methods, such as hypothesis testing, have been commonly used by pharmaceutical industry and regulators to evaluate treatment efficacy on PRO endpoints. However, the analysis of PRO data remains challenging due to high variability and missing data issues. Here, we will present examples where inappropriate statistical analyses of PRO data can confound treatment efficacy analyses. To overcome these challenges, we propose the application of individual participant data and population models. Population models have been extensively used in pharmacokinetics and pharmacodynamics analyses and are well accepted by regulators. However, their potential in PRO data analyses, particularly in the field of oncology, remains largely untapped. This perspective paper aims to highlight the value of population modeling approaches in PRO data analyses for oncology clinicians and researchers. Population models integrate individual participant data and can effectively handle the substantial variability in PRO measurements by incorporating covariates, between-subject variability, and accounting for measurement noise. By leveraging information from the population, this approach also provides accurate estimations for participants with missing data or sparse sampling. Moreover, these models could be applied to predict long-term PRO dynamics. If used appropriately, population modeling approaches could revolutionize the analysis of PRO data in oncology drug development, enabling a more comprehensive understanding of the impact of treatment on patients' lives. Our aim is to encourage stakeholders to consider population modeling as a standard and effective tool to enhance decision-making and ultimately improve patient care.
Clinical Severity and Outcomes in Large Infarcts With Endovascular Therapy: A Post Hoc Analysis of the ANGEL-ASPECT Trial
Authors: Lu Qixuan , Zheng Lina , Nie Ximing , Wang Mengxing , Duan Wanying , Liu Xin , Zhang Zhe , Wen Miao , Yang Zhonghua , Leng Xinyi , Pan Yuesong , Nguyen Thanh N. , Liu Liping 
Published: February 2025

BACKGROUND:
Endovascular therapy (EVT) has been proven effective for patients with acute ischemic stroke with large infarcts. This study aimed to explore the impact of clinical severity on the efficacy of EVT in such patients.

METHODS:
This was a post hoc analysis of the ANGEL-ASPECT trial (Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core), a randomized controlled trial that enrolled patients from 46 centers across China between October 2, 2020, and May 18, 2022. These patients had large infarcts (defined as Alberta Stroke Program Early CT Score of 3–5 or infarct-core volume 70–100 mL) due to anterior-circulation large vessel occlusion within 24 hours after stroke onset with a National Institutes of Health Stroke Scale score of 6 to 30. Patients were randomized into either the EVT group or the medical management alone (MM) group. For this analysis, we categorized the patients into 2 subgroups: moderate stroke and severe stroke, based on a baseline National Institutes of Health Stroke Scale score of either <20 or ≥20. The primary outcome was the ordinal 90-day modified Rankin Scale score (0, no symptoms, to 6, death).

RESULTS:

Among 455 eligible patients, 347 (76.3%) presented with moderate stroke (170 received EVT, 177 underwent MM), and 108 (23.7%) had severe stroke (60 received EVT, 48 underwent MM). A significant shift toward better outcomes in the 90-day modified Rankin Scale distribution was observed in the EVT group compared with the MM group (generalized odds ratio, 1.66 [95% CI, 1.29–2.13];
P
<0.001) among patients with moderate stroke. However, this was not the case for those with severe stroke (generalized odds ratio, 1.06 [95% CI, 0.54–2.10];
P
=0.87), indicating a significant interaction (
P
=0.03).

CONCLUSIONS:
In patients with acute large infarcts, EVT was associated with improved functional outcomes compared with MM in patients with moderate stroke. However, no significant difference was observed in patients with severe stroke. Therefore, stroke severity should be considered when selecting patients with large infarcts for EVT.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04551664.
A New Species of Triaenodes (Trichoptera: Leptoceridae), based on morphological and molecular data, from Kaeng Khoi Waterfall, Chumphon Province, southern Thailand
Authors: LAUDEE PONGSAK , MALICKY HANS , TAKENAKA MASAKI , SAWANGARROM PHUWADON , SUWANNARAT NANNAPHAT 
Published: February 2025

A new species of Triaenodes tipmaneei sp. nov. is described and illustrated based on the male and female genitalia. The mitochondrial DNA (mtDNA) cytochrome c oxidase subunit I (COI) of the new species and of the most similar species T. themis Malicky and Prommi 2006 were analyzed. The male genitalia of Triaenodes tipmaneei sp. nov. is distinguished from other species in the genus by the shape of inferior appendages. Inferior appendages of the new species are without recurved processes; the dorsal branch is divided into a dorsal lobe and two processes, with the upper process curved upward and bifid, and the lower process slender and with pointed apex; the main body of the appendage has a short slender apicolateral process, the mesal process is short and pointed, the ventral process is stout, and the apex is pointed. The genetic distance between T. tipmaneei sp. nov. and T. themis, based on the mtDNA COI region, was 8.5 precent, indicating a large genetic differentiation between the two species.
Reply to “Comment on ‘Marathon versus Sprint: Two Modes of Tropical Cyclone Rapid Intensification in a Global Convection-Permitting Simulation’”
Authors: Judt Falko , Rios-Berrios Rosimar , Bryan George H. 
Published: February 2025

Abstract
This reply addresses the comments by Montgomery and Smith on “Marathon versus sprint: Two modes of tropical cyclone rapid intensification in a global convection-permitting simulation.”
Predicting Return-to-Manual Performance in Lower- and Higher-Degree Automation
Authors: Griffiths Natalie , Bowden Vanessa K. , Wee Serena , Loft Shayne 
Published: February 2025

Objective To examine operator state variables (workload, fatigue, trust in automation, task engagement) that potentially predict return-to-manual (RTM) performance after automation fails to complete a task action. Background Limited research has examined the extent to which within-person variability in operator states predicts RTM performance, a prerequisite to adapting work systems based on expected performance degradation/operator strain. We examine whether operator states differentially predict RTM performance as a function of degree of automation (DOA). Method Participants completed a simulated air traffic control task. Conflict detection was assisted by either a higher- or lower-DOA. When automation failed to resolve a conflict, participants needed to prevent that conflict (i.e., RTM). Participants’ self-reported workload, fatigue, trust in automation, and task engagement were periodically measured. Results Participants using lower DOA were faster to resolve conflicts (RTM RT) missed by automation than those using higher DOA. DOA did not moderate the relationship between operator states and RTM performance. Collapsed across DOA, increased workload (relative to participants’ own average) and increased fatigue (relative to sample average, or relative to own average) led to the resolution of fewer conflicts missed by automation (poorer RTM accuracy). Participants with higher trust (relative to own average) had higher RTM accuracy. Conclusions Variation in operator state measures of workload, fatigue, and trust can predict RTM performance. However, given some identified inconsistency in which states are predictive across studies, further research is needed. Applications Adaptive work systems could be designed to respond to vulnerable operator states to minimise RTM performance decrements.
Artificial UV and natural ageing of polycarbonate/poly(butylene terephthalate) binary blend and reprocessing of aged blends
Authors: Kuram Emel , Ozcelik Babur , Sarman Omer Faruk , Kocoglu Hurol , Ayas Hamza , Dogan Mehmet 
Published: February 2025

In this research, the effect of reprocessing for aged polycarbonate (PC)/poly (butylene terephthalate) (PBT) blends was determined on the mechanical properties (tensile, impact, flexural), melt flow index and morphology. Virgin PC/PBT blends were injection molded as the tensile, flexural and impact samples to evaluate the mechanical, rheological, and morphological properties. After that, samples were exposed to artificial accelerated ageing in an QUV chamber (simulating outdoor weathering with alternating cycles of ultraviolet (UV) light and moisture at controlled elevated temperature) for up to 336 hours and natural ageing in Gebze (Turkey) for up to 1 year between May 2017 and May 2018. After these ageing processes, naturally and UV aged specimens were ground, and the ground specimens were mixed with virgin PC/PBT blends at different ratios (25%, 50% and 75% by weight). The mixed materials were re-molded to fabricate test specimens and then characterized. In summary, in current study, the mechanical, rheological, and morphological properties of virgin, aged in natural for 12 months, aged in UV chamber for 336 hours and mixture of virgin-aged PC/PBT were investigated.
Sustainable biocomposites based on polylactic acid and agro waste biofillers for lightweight applications: Fabrication and properties
Authors: Ramesh M , Rajeshkumar L , Sanjay MR , Siengchin Suchart 
Published: February 2025

The utilization of agricultural biomass residues as biofillers in polymer composites enhances the evolution of green and sustainable biocomposites that assist in progressing towards sustainable development goals. Agricultural biomass residues such as peels, seeds, stalks, and bunches increase with the increase in crop production. The current research focuses on evaluating the influence of waste pomegranate peel biofiller as a novel particulate reinforcement on the mechanical, thermal, and thermomechanical properties of polylactic acid (PLA)-based biocomposites. The pomegranate peel particulate biofillers were characterized using various characterization techniques. Different concentrations of biofillers ranging from 5–25 wt. % was used for the preparation of PLA-based composites. The fabricated composites were subjected to various mechanical and thermal tests. The experimental investigations showed that 15 wt. % of biofiller-reinforced biocomposites exhibited a 13.6 % increase in tensile strength, 42 % increase in tensile modulus, 9.34% increase in compressive strength, 41% in impact strength, and 26 % increase in hardness and better thermal and thermomechanical behaviour when compared with virgin PLA. The failure morphology of the biocomposites portrayed better interfacial bonding between composite constituents. It can be concluded from this study that the pomegranate peel powder can act as potential biofiller reinforcements for producing biocomposites for various lightweight structural applications. Hybridization with biofibers and other biofillers may enhance the application spectrum of these biocomposites further.
Rhynchophylline promotes microglia phenotypic transformation and repair of cerebral ischaemic injury through the JAK2/STAT3 pathway
Authors: Bai Peng , Li Caixia , Yin Luwei , Li Yao , Ju Meng , Wang Laicang 
Published: February 2025

Background Rhynchophylline (RIN) is an alkaloid known for its ability to effectively block signal transduction related to various neurodegenerative diseases. However, the specific mechanism by which RIN regulates microglial activation and cerebral ischemia remains unexplored. This study aims to investigate the function and molecular pathways through which RIN activates the JAK2/STAT3 signaling cascade, promoting the transformation of microglial phenotypes that contribute to recovery from cerebral ischemic injury. Methods By establishing a microglia oxygen glucose deprivation/reoxygenation (OGD/R) model and a middle cerebral artery occlusion animal model, we assessed changes in the expression of phenotype-specific marker factors for M1 and M2 microglia, as well as key proteins in the JAK2/STAT3 pathway, utilizing ELISA and Western blot techniques. Histological examination, including HE staining, TUNEL assay, and immunofluorescence, was employed to evaluate pathological changes in brain tissue, along with cell apoptosis and proliferation. Results The results indicated that microglial activity was significantly reduced and shifted towards the M1 phenotype following OGD/R. However, RIN treatment reversed these changes. When JAK2/STAT3 inhibitors were combined with RIN, it inhibited RIN’s protective effect. Animal studies have shown that RIN reduces histopathological changes associated with cerebral ischemia. Additionally, RIN inhibited microglial proliferation in ischemic cortical tissue and increased the expression of M2-type marker proteins, as well as the levels of phosphorylated JAK2 and STAT3 in the ischemic tissue. Conclusion In conclusion, this study indicates that RIN may protect against cerebral ischemic injury by activating the JAK2/STAT3 pathway, which promotes the transition of microglia to the M2 phenotypic.
Infant feeding experiences of women with systemic lupus erythematosus: A qualitative study
Authors: Lieber Sarah B , Stamm Bessie C , Young Sarah R , Rose-Smith Jillian , Kleinman Juliette , Smole Amaya , Vega JoAnn , Siegel Caroline H , Barbhaiya Medha , Mandl Lisa A , Lockshin Michael D , Sammaritano Lisa R 
Published: February 2025

Background/Objective Although breastfeeding is safe in women with systemic lupus erythematosus (SLE) who take breastfeeding-compatible medications, rates of breastfeeding are inconsistent, and little is known about the lived experiences surrounding infant feeding among women with SLE. In this qualitative study, we identified factors that influence infant feeding practices of these women. Methods Using a phenomenological approach, we conducted and thematically analyzed semi-structured interviews on infant feeding practices with adult women with SLE evaluated at a single tertiary care musculoskeletal center who had given birth within the last 6 years. We collected and summarized maternal, SLE disease, and pregnancy characteristics using descriptive statistics. Results Semi-structured interviews were conducted among 19 women with SLE with mean age of 36.1 years at delivery. We identified four overarching themes: general considerations related to infant feeding, medical considerations related to infant feeding, perspectives on infant feeding, and messages to peers with SLE and healthcare providers. Conclusions We identified both SLE-specific and disease-agnostic factors impacting infant feeding behaviors in women with SLE. SLE-specific factors influencing infant feeding practices should be viewed holistically within the context of individuals’ personal preferences, which in turn may be shaped by interpersonal and cultural factors. Our findings can inform shared decision-making related to infant feeding practices in women with SLE, as well as tailored educational strategies to meet their unique needs.
Development of a New Simulator for Training Nelore Artificial Insemination
Authors: Azuaga Filho Heitor , Colaço Bruno , Payan-Carreira Rita 
Published: February 2025

Background Regular training is crucial for student and novice operators conducting artificial insemination to ensure successful cattle reproduction. Standardized repetitions help generate autonomy and self-confidence. It is also essential for proficiency in the technique, assuring consistency and success in the procedure. Training live animals for AI procedures raises ethical concerns and requires a regular supply of animals. Alternatives have been developed, either as manikins or simulators, usually based on Bos taurus genital tracts. Aims This work aimed to describe the development process of an artificial insemination simulator for Nelore cattle named “Training Artificial Insemination for Nelore” (TrAI4Nel). This simulator enables the effective training of professionals and reduces the number of animals used for this purpose. Methods The TrAI4Nel simulator was developed using 3D modeling and printing techniques that accurately reproduce the anatomical characteristics of the Nelore reproductive tract. Electronic components were incorporated to provide a realistic simulation and allow real-time procedure evaluation. Results Throughout the development of this simulator, two main shortcomings have been detected and corrected. Compared with commercially available products, TrAI4Nel incorporates significant innovations. The implemented electronic system provides greater precision in training, simulating the ideal moment for semen deposition, and allowing real-time assessment of the trainee. Conclusions This simulator can become a valuable tool in professional training. It allows interactive learning and provides a realistic, affordable experience. It also reduces trainees’ emotional stress and animal injuries, emphasizing ethical aspects and efficiency in training in this area.