bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reforming the Way: The Palace and the Village in Daoist Paradise
Authors: Walker Nathaniel Robert 
Published: April 2013

ABSTRACT
Like any major religion, Daoism has a complex history and multiple branches, but among its most persistent elements are secluded mountain paradises populated both by divinities and by human beings. Ideas regarding the means of access to these transcendent abodes have been less consistent: Should Daoist adepts strive to be virtuous, or should they labor to “restore” themselves through esoteric, elite magic? A provocative answer to this question was given by the poet Tao Qian (a.d. 365–427), who sided with Daoism's most ancient authority by suggesting that Daoist harmony could not be achieved through mere individual study but, rather, could be found only in an uncorrupted social fabric, in his case defined as a humble lost village. This utopian vision, brought to life in the poem Peach Blossom Spring, not only rejected the esoteric values of the Daoist elite but also called into question imperial hegemonic structures in general. The fact that the poem's rustic utopian enclave was understood in these terms by generations of Chinese scholars and artists is revealed by the contrasting architectural forms used to represent these alternative concepts of the Daoist ideal: the palace and the village, the garden of leisure and the working farm.
Local Tomography Study of the Fracture of an ERG Metal Foam
Authors: Zhang Tao , Maire Eric , Adrien Jerome , Onck Patrick R. , Salvo Luc 
Published: April 2013

AbstractAs one of the most important analysis techniques for non‐destructive imaging, X‐ray tomography has been widely used in materials science, medical science, and industry to evaluate the behavior of porous materials. By using this method, a three dimensional volume can be inspected in order to visualize in situ the progress of damage in materials and this can be analyzed qualitatively and quantitatively. In the present study, we have used X‐ray tomography to investigate the fracture behavior of an ERG open cell aluminum foam. The process of damage development of a sample undergoing tension and the relation between the inter‐metallics and the cracks can be observed totally by the X‐ray tomography set‐up. Local tomography has in particular been used to image the microstructure at high resolution. A finite element model has also been developed in order to simulate this process of the damage using the 3D data obtained by the tomography.
Bio‐Inspired Superoleophobic Fluorinated Wax Crystalline Surfaces
Authors: Pechook Sasha , Kornblum Noga , Pokroy Boaz 
Published: April 2013

AbstractA novel, single‐step and single‐component bio‐inspired fabrication method of hierarchical superoleophobic surfaces is presented. The method consists in thermal deposition of self‐assembling ultra‐low‐surface‐energy fluorinated wax on diverse surfaces. The thermal deposition results in crystalline, oriented, three‐dimensional hierarchical structures with high surface roughness and re‐entrant curvature, which in combination with the low surface energy of the fluorinated wax results in high contact angles of low‐surface‐tension liquids and low contact‐angle hysteresis (CAH) values (Δθ). The values achieved for Δθ are below 10° even for ethanol, which exhibits a surface tension as low as 22.4 mN·m−1. In addition to their superoleophobic properties our substrates exhibit extreme superhydrophobic qualities (CAH as low as 2° and contact angle >170°) with exceptional surface stability over many months. The proposed fabrication method may be utilized for a variety of applications where non‐wetting of low‐surface‐tension liquids is required, for example non‐staining surfaces and antifouling. The ease of fabrication and the variety of substrates that can be modified will undoubtedly widen its use.
The Formation of Performance Enhancing Pseudo‐Composites in the Highly Active La1–xCaxFe0.8Ni0.2O3 System for IT‐SOFC Application
Authors: Ortiz‐Vitoriano Nagore , de Larramendi Idoia Ruiz , Cook Stuart N. , Burriel Mónica , Aguadero Ainara , Kilner John A. , Rojo Teófilo 
Published: April 2013

AbstractThe La1–xCaxFe0.8Ni0.2O3–δ (0 ≤ x ≤ 0.9) system is investigated for potential application as a cathode material for intermediate temperature solid oxide fuel cells (IT‐SOFCs). A broad range of experimental techniques have been utilized in order to elucidate the characteristics of the entire compositional range. Low A‐site Ca content compositions (x ≤ 0.4) feature a single perovskite solid solution. Compositions with 40% Ca content (x = 0.4) exhibit the highest electrical and ionic conductivities of these single phase materials (250 and 1.9 × 10−3 S cm−1 at 800 °C, respectively), a level competitive with state‐of‐the‐art (La,Sr)(Fe,Co)O3. Between 40 and 50% Ca content (0.4 > x > 0.5) a solubility limit is reached and a secondary, brownmillerite‐type phase appears for all higher Ca content compositions (0.5 ≤ x ≤ 0.9). While typically seen as detrimental to electrochemical performance in cathode materials, this phase brings with it ionic conductivity at operational temperatures. This gives rise to the effective formation of pseudo‐composite materials which feature significantly enhanced performance characteristics, while also providing the closest match in thermal expansion behavior to typical electrolyte materials. This all comes with the advantage of being produced through a simple, single‐step, low‐cost production route without the issues associated with typical composite materials. The highest performing pseudo‐composite material (x = 0.5) exhibits electronic conductivity of 300–350 S cm−1 in the 600–800 °C temperature range while the best polarisation resistance (Rp) values of approximately 0.2 Ω cm2 are found in the 0.5 ≤ x ≤ 0.7 range.
A de novo GLI3 mutation in a patient with acrocallosal syndrome
Authors: Speksnijder Leonie , Cohen‐Overbeek Titia E. , Knapen Maarten F.C.M. , Lunshof Simone M. , Hoogeboom A. Jeannette M. , van den Ouwenland Ans M. , de Coo Irenaneus F.M. , Lequin Maarten H. , Bolz Hanno J. , Bergmann Carsten , Biesecker Leslie G. , Willems Patrick J. , Wessels Marja W. 
Published: April 2013

AbstractAcrocallosal syndrome is characterized by postaxial polydactyly, macrocephaly, agenesis of the corpus callosum, and severe developmental delay. In a few patients with this disorder, a mutation in the KIF7 gene has been reported, which was associated with impaired GLI3 processing and dysregulaton of GLI3 transcription factors. A single patient with acrocallosal syndrome and a de novo p.Ala934Pro mutation in GLI3 has been reported, whereas diverse and numerous GLI3 mutations have also been described in syndromes with overlapping clinical manifestations, including Greig cephalopolysyndactyly syndrome, Pallister–Hall syndrome, trigonocephaly with craniosynostosis and polydactyly, oral–facial‐digital syndrome, and non‐syndromic polydactyly. Here, we describe a second patient with acrocallosal syndrome, who has a de novo, novel c.2786T > C mutation in GLI3, which predicts p.Leu929Pro. This mutation is in the same domain as the mutation in the previously reported patient. These data confirm that mutations in GLI3 are a cause of the acrocallosal phenotype. © 2013 Wiley Periodicals, Inc.
Development of the human heart
Authors: Sylva Marc , van den Hoff Maurice J.B. , Moorman Antoon F.M. 
Published: April 2013

AbstractMolecular and genetic studies around the turn of this century have revolutionized the field of cardiac development. We now know that the primary heart tube, as seen in the early embryo contains little more than the precursors for the left ventricle, whereas the precursor cells for the remainder of the cardiac components are continuously added, to both the venous and arterial pole of the heart tube, from a single center of growth outside the heart. While the primary heart tube is growing by addition of cells, it does not show significant cell proliferation, until chamber differentiation and expansion starts locally in the tube, by which the chambers balloon from the primary heart tube. The transcriptional repressors Tbx2 and Tbx3 locally repress the chamber‐specific program of gene expression, by which these regions are allowed to differentiate into the distinct components of the conduction system. Molecular genetic lineage analyses have been extremely valuable to assess the distinct developmental origin of the various component parts of the heart, which currently can be unambiguously identified by their unique molecular phenotype. Despite the enormous advances in our knowledge on cardiac development, even the most common congenital cardiac malformations are only poorly understood. The challenge of the newly developed molecular genetic techniques is to unveil the basic gene regulatory networks underlying cardiac morphogenesis. © 2013 Wiley Periodicals, Inc.
Ring chromosome 9 in a girl with developmental delay and dysmorphic features: Case report and review of the literature
Authors: Sibbesen Else la Cour , Jespersgaard Cathrine , Alosi Daniela , Bisgaard Anne‐Marie , Tümer Zeynep 
Published: April 2013

AbstractIn this report, we describe a female child with dysmorphic features and developmental delay. Chromosome microarray analysis followed by conventional karyotyping revealed a ring chromosome 9 with a 12 Mb deletion at 9pter‐p23 and a 540 kb deletion at 9q34.3‐qter. Four percent of the analyzed cells had monosomy 9. The patient has the features of both the Kleefstra syndrome and the chromosome 9p‐syndrome, including trigonocephaly, long philtrum, hypertelorism, and retro‐/micronagthia. The deletion of the patient overlaps with several of the proposed critical regions for the 9p deletion syndrome. © 2013 Wiley Periodicals, Inc.
A novel inverted 17p13.3 microduplication disrupting PAFAH1B1 (LIS1) in a girl with syndromic lissencephaly
Authors: Classen Sabrina , Goecke Timm , Drechsler Matthias , Betz Beate , Nickel Natalie , Beier Manfred , Schaper Jörg , Karenfort Michael , Royer‐Pokora Brigitte 
Published: April 2013

AbstractWe describe a female patient with mild lissencephaly (pachygyria), severe intellectual disability, and facial dysmorphisms with an inverted 1.4 Mb microduplication of chromosome 17p13.3. The 17p13.3 microduplication syndrome is associated with mild intellectual disabiltiy and contains, among others, the PAFAH1B1 (LIS1) gene, whereas microdeletions of the same segment cause Miller–Dieker syndrome (MDS) with severe to profound retardation. The duplication identified in our patient encompasses 29 genes, including CRK and YWHAE. The proximal breakpoint of the duplication is located in the first intron of the PAFAH1B1 gene. Analysis of total RNA showed that only one PAFAH1B1 allele is expressed. Therefore, this patient has a unique alteration: a duplication including YWHAE and CRK and haploinsufficiency of PAFAH1B1. Overexpression of YWHAE is associated with macrosomia, mild developmental delay, autism and facial dysmorphisms, and deletion of PAFAH1B1 alone leads to isolated lissencephaly (ILS). The patient described here shares features with MDS, but she is affected to a lesser degree. Her facial features are similar to MDS, and she has manifestations seen in other cases with YWHAE duplication. © 2013 Wiley Periodicals, Inc.
Data mining using regularized adaptive B‐splines regression with penalization for multi‐regime traffic stream models
Authors: Sun Lu , Pan Yiyong , Gu Wenjun 
Published: April 2013

SUMMARYThis paper presents a new data mining method that integrates adaptive B‐spline regression and traffic flow theory to develop multi‐regime traffic stream models (TSMs). Parameter estimation is implemented adaptively and optimally through a constrained bi‐level programming method. The slave programming determines positions of knots and coefficients of the B‐spline by minimizing the error of B‐spline regression. The master programming model determines the number of knots through a regularized function, which balances model accuracy and model complexity. This bi‐level programming method produces the best fitting to speed–density observations under specific order of splines and possesses great flexibility to accommodate the exhibited nonlinearity in speed–density relationships. Jam density can be estimated naturally using spline TSM, which is sometimes hardly obtainable in many other TSM. Derivative continuity up to one order lower than the highest spline degree can be preserved, a desirable property in some application. A five‐regime B‐spline model is found to exist for generalized speed–density relationships to accommodate five traffic operating conditions: free flow, transition, synchronized flow, stop and go traffic, and jam condition. A typical two‐regime B‐spline form is also explicitly given, depending only on free‐flow speed, optimal speed, optimal density, and jam density. Copyright © 2013 John Wiley & Sons, Ltd.
Effects of 940 MHz EMF on luciferase solution: Structure, function, and dielectric studies
Authors: Sefidbakht Yahya , Hosseinkhani Saman , Mortazavi Mojtaba , Tavakkolnia Iman , Khellat Mohammad R. , Shakiba‐Herfeh Mahdi , Saviz Mehrdad , Faraji‐Dana Reza , Saboury Ali A. , Sheibani Nader , Moosavi‐Movahedi Ali A. 
Published: April 2013

AbstractWe designed a rectangular waveguide exposure system to study the effects of mobile phone frequency (940 MHz) electromagnetic fields (EMF) on luciferase structure and activity. The luciferase activity of exposed samples was significantly higher than that of unexposed samples. Dynamic light scattering of the exposed samples showed smaller hydrodynamic radii compared to unexposed samples (20 nm vs. 47 nm ± 5%). The exposed samples also showed less tendency to form aggregates, monitored by turbidity measurements at λ = 360 nm. A microwave dielectric measurement was performed to study the hydration properties of luciferase solutions with a precision network analyzer over frequency ranges from 0.2 to 20 GHz before and after exposure. The change in the dielectric properties of the exposed luciferase solution was related to the disaggregation potency of the applied field. Together, our results suggested that direct interactions with luciferase molecules and its dipole moment were responsible for the reduced aggregation and enhanced luciferase activity upon exposure to the EMF. Bioelectromagnetics. 34:489–498. © 2013 Wiley Periodicals, Inc.
Thermal quenching of luminescence of LiSr4(BO3)3:Eu2+ orange‐emitting phosphor
Authors: Zhang Xinguo , Zhou Liya , Gong Menglian 
Published: April 2013

ABSTRACTAn orange‐emitting phosphor, Eu2+‐activated LiSr4(BO3)3, was synthesized using the conventional solid‐state reaction. The photoluminescence excitation and emission spectra, and temperature dependence of the luminescence intensity of the phosphor were investigated. The results showed that LiSr4(BO3)3:Eu2+ could be efficiently excited by incident light of 250–450 nm, and emits a strong orange light. With increasing temperature, the emission bands of LiSr4(BO3)3:Eu2+ show an abnormal blue‐shift with broadening bandwidth and decreasing emission intensity. Copyright © 2013 John Wiley & Sons, Ltd.
Evaluation of lophine derivatives as L‐012 (luminol analog)‐dependent chemiluminescence enhancers for measuring horseradish peroxidase and H2O2
Authors: Ichibangase T. , Ohba Y. , Kishikawa N. , Nakashima K. , Kuroda N. 
Published: April 2013

ABSTRACT8‐Amino‐5‐chloro‐7‐phenylpyrido[3,4‐d]pyridazine‐1,4(2H,3H)dione (L‐012) was recently synthesized as a new chemiluminescence (CL) probe; the light intensity and the sensitivity of L‐012 are higher than those of other CL probes such as luminol. Previously, our group developed four lophine‐based CL enhancers of the horseradish peroxidase (HRP)‐catalyzed CL oxidation of luminol, namely 2‐(4‐hydroxyphenyl)‐4,5‐diphenylimidazole (HDI), 2‐(4‐hydroxyphenyl)‐4,5‐di(2‐pyridyl)imidazole (HPI), 4‐(4,5‐diphenyl‐1H‐imidazol‐2‐yl)phenylboronic acid (DPA), and 4‐[4,5‐di(2‐pyridyl)‐1H‐imidazol‐2‐yl]phenylboronic acid (DPPA), and showed that DPPA was suitable for the photographic detection of HRP. In this study, we replaced luminol with L‐012 and evaluated these as L‐012‐dependent CL enhancers. In addition, to detect HRP and/or H2O2 with higher sensitivity, each detection condition for the L‐012–HRP–H2O2 enhanced CL was optimized. All the derivatives enhanced the L‐012‐dependent CL as well as luminol CL; HPI generated the highest enhanced luminescence. Under optimized conditions for HRP detection, the detection limit of HRP was 0.08 fmol. By contrast, the detection limit of HRP with the enhanced L‐012‐dependent CL using 4‐iodophenol, which is a common enhancer of luminol CL, was 1.1 fmol. With regard to H2O2 detection, the detection limits for enhanced CL with HPI and 4‐iodophenol were 0.29 and 1.5 pmol, respectively. Therefore, it is demonstrated that HPI is the most superior L‐012‐dependent CL enhancer. Copyright © 2013 John Wiley & Sons, Ltd. Copyright © 2013 John Wiley & Sons, Ltd.
Robust stability analysis inspired by classical statistical principles
Authors: Silva Nilton , Bispo Heleno , Brito Romildo , Manzi João 
Published: April 2013

AbstractAn analysis was made of robust stability by estimating the robust confidence region for the roots of the characteristic Equation of a process, which uses a typical PID controller with auto‐tuning. From standard statistical concepts, considerations on the statistical distance associated with the chi‐square distribution were taken into account when establishing the methodology, which enabled the region of robust stability to be found. The results show the robust stability region for all eigenvalues of characteristic equation, thus demonstrating the ability of the procedure. The region of stability can be updated online, thus enabling the stability of the system to be continuously evaluated, with little computational effort.
Outcomes in stage I testicular seminoma: A population‐based study of 9193 patients
Authors: Beard Clair J. , Travis Lois B. , Chen Ming‐Hui , Arvold Nils D. , Nguyen Paul L. , Martin Neil E. , Kuban Deborah A. , Ng Andrea K. , Hoffman Karen E. 
Published: April 2013

BACKGROUNDFew studies have quantified temporal patterns of cause‐specific mortality in contemporary cohorts of men with early‐stage seminoma. Given that several management strategies can be applied in these patients, each resulting in excellent long‐term survival, it is important to evaluate associated long‐term sequelae. In particular, data describing long‐term risks of cardiovascular disease (CVD) are conflicting.METHODSWe identified 9193 men diagnosed with stage I seminoma (ages 15‐70 years) in the population‐based SEER registries (1973‐2001). We calculated survival estimates, standardized mortality ratios (SMRs), and adjusted hazard rates (AHRs).RESULTSDuring 121,037 person‐years of follow‐up (median, 12.3 years), 915 deaths (SMR, 1.23; 95% CI, 1.16‐1.32) were reported, with significant excesses for suicide (n = 39; SMR, 1.45; 95% CI, 1.06‐1.98), infection (n = 58; SMR, 2.32; 95% CI, 1.80‐3.00), and second malignant neoplasms (SMNs; n = 291; SMR, 1.81; 95% CI, 1.61‐2.03), but not CVD (n = 201; SMR, 0.91; 95% CI, 0.80‐1.05). After radiotherapy (78% patients), CVD deaths were not increased (n = 158; SMR, 0.89; 95% CI, 0.76‐1.04), in contrast to SMN deaths (n = 246; SMR, 1.89; 95% CI, 1.67‐2.14). SMN mortality was higher among patients administered radiotherapy than among those not given radiotherapy (AHR, 1.36; 95% CI, 0.99‐1.88;P = .059), with a cumulative 15‐year risk of 2.64% (95% CI, 2.19‐3.16). Suicide, although rare, accounted for 1 in 230 deaths.CONCLUSIONSModern radiotherapy as applied in this large population‐based study is not associated with excess CVD mortality. Although increased all‐cause mortality exists, cumulative SMN risk is considerably smaller than reported in historical series, but additional follow‐up will be required to characterize long‐term trends. The increased risk of suicide, previously unreported in men with stage I seminoma, requires confirmation.Cancer2013;119:2771–2777. ©2013 American Cancer Society.
Posterior reversible encephalopathy syndrome in neuroblastoma patients receiving anti‐GD2 3F8 monoclonal antibody
Authors: Kushner Brian H. , Modak Shakeel , Basu Ellen M. , Roberts Stephen S. , Kramer Kim , Cheung Nai‐Kong V. 
Published: April 2013

BACKGROUNDPosterior reversible encephalopathy syndrome (PRES) comprises clinical and radiologic findings with rapid onset and potentially dire consequences. Patients experience hypertension, seizures, headache, visual disturbance, and/or altered mentation. Magnetic resonance imaging reveals edematous changes in the brain (especially in the parietal and occipital lobes). In this report, the authors describe PRES associated with antidisialoganglioside (anti‐GD2) monoclonal antibody (MoAb) immunotherapy, which is now standard for high‐risk neuroblastoma but has not previously been implicated in PRES.METHODSSuccessive clinical trials using the anti‐GD2 MoAb 3F8 (a murine immunoglobulin 3 MoAb specific for GD2) for patients with neuroblastoma involved multiple cycles of standard‐dose 3F8 (SD‐3F8) (20 mg/m2 daily for 5 days per cycle) or 2 cycles of high‐dose 3F8 (HD‐3F8) (80 mg/m2 daily for 5 days per cycle) followed by cycles of SD‐3F8.RESULTSPRES was diagnosed in 5 of 215 patients (2.3%), including 3 of 160 (1.9%) who received SD‐3F8 and 2 of 55 (3.6%) who received HD‐3F8 (P = .6). All 5 patients had a rapid return to clinical‐radiologic baseline. PRES occurred in 3 of 26 patients (11.5%) whose prior treatment included external‐beam radiotherapy to the brain (2 of 6 patients status‐post total body irradiation and 1 of 20 patients status‐post craniospinal irradiation) compared with 2 of 189 patients (1.1%) who had not received prior brain irradiation (P = .01). Hypertension, which is strongly linked to PRES, reached grade 3 toxicity in 12 of 215 patients (5.6%), including the 5 patients with PRES and 7 patients without PRES.CONCLUSIONSPatients who receive anti‐GD2 MoAb immunotherapy should be closely monitored for, and undergo urgent treatment or evaluation of, symptoms that may herald PRES (eg, hypertension or headaches). Prior brain irradiation may be a predisposing factor for PRES with this immunotherapy. Cancer 2013;119:2789–2795. © 2013 American Cancer Society.
Syntheses of New Carbanucleosides by Pericyclic Reactions
Authors: Scagnelli Luca , Memeo Misal Giuseppe , Carosso Serena , Bovio Bruna , Quadrelli Paolo 
Published: April 2013

AbstractThe synthesis of heterobase‐functionalized cyclopentene derivatives as valuable substrate for the introduction of suitable substituents through pericyclic reactions is reported. The structures of ene and 1,3‐dipolar adducts are discussed, and the primary antiviral activities of some adenine derivatives are reported.
Purging Disorder: A Comparison to Established Eating Disorders with Purging Behaviour
Authors: Koch Sonja , Quadflieg Norbert , Fichter Manfred 
Published: April 2013

AbstractThis study is part of the larger Christina Barz Study, and it compared consecutively admitted patients with purging disorder (PurD; N = 225) with consecutively admitted patients with anorexia nervosa binge eating/purging subtype (AN‐bp; N = 503) and bulimia nervosa purging subtype (BN‐p; N = 756). Participants answered self‐rating questionnaires on admission, at the end of inpatient treatment, and in a 5‐year follow‐up. Patients with PurD reported lower severity of general psychopathology than patients with AN‐bp and lower severity of eating disorder symptoms than patients with AN‐bp and BN‐p on admission. Eating disorder symptoms of patients with PurD improved less during the course than of the comparison groups. Diagnostic perseverance was stronger in the PurD group than for patients with AN‐bp; mortality was higher than for patients with BN‐p. Predictors for better outcome differed for the groups. Our results provide new data about the long‐term course of patients with PurD and indicate clinical relevance of the disorder. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.