bluuebunny/crossref_metadata_2025_split huggingface dataset:
Four Cases of Pustulotic Arthro‐Osteitis
Authors: Jang Kyoung Ae , Sung Kyung Jeh , Moon Kee Chan , Koh Jai Kyoung , Choi Jee Ho 
Published: April 2015

AbstractWe describe four cases of pustulotic arthro‐osteitis. All of them suffered from anterior chest wall symptoms, such as swelling and pain on the sternoclavicular joint, sternal angle area, sternocostal joint, and costochondral junction. Although chest X‐ray findings were all normal, 90mTc‐scintigraphy revealed increased uptake in the affected areas in all cases. Laboratory examinations including rheumatoid factor were negative or normal except for elevation of the erythrocyte sedimentation rate and C‐reactive protein in 2 cases. After treatment with non‐steroidal anti‐inflammatory drugs and etretinate or topical PUVA, the skin lesions on the palms and soles and the arthro‐osteitis were moderately improved. Pustulotic arthro‐osteitis should be considered when a patient with pustulosis palmoplantaris complains of anterior chest wall pain and other joint pain.
The Proliferation and Differentiation of Neonatal Epidermal Melanocytes in F1 Hairless Mice of HR‐1 × HR/De in Serum‐Free Culture
Authors: Furuya Rikako , Akiu Satoru , Naganuma Masako , Fukuda Minoru , Hirobe Tomohisa 
Published: April 2015

AbstractTo investigate the characteristics of the proliferation and differentiation of epidermal melanocytes in F1 hairless mice of HR‐1 × HR/De parents in vitro, cell suspensions of the neonatal epidermis were cultured in a serum‐free medium supplemented with dibutyryl adenosine 3‘,5‘‐cyclic monophosphate (DBcAMP) and/or basic fibroblast growth factor (bFGF). The differentiation of melanocytes was induced by treatment with DBcAMP. In contrast, the sustained proliferation of melanoblasts was induced by combined treatment with DBcAMP and bFGF. The melanoblasts could be subcultured in serum‐free medium supplemented with the two factors in the presence of keratinocytes, but not in their absence. This is the first report of successful culture of melanoblasts and melanocytes from hairless mice; it is expected to be useful in understanding the mechanism of the development of pigmented spots in the epidermis of (HR‐1 × HR/De) F1 mice, which are reported to be induced by repeated exposure to ultraviolet light B.
Treatment of Cutaneous Leishmaniasis by Direct Current Electrotherapy: The Baghdadin Device
Authors: Sharquie Khalifa E. , Al‐Hamamy Hayder , El‐Yassin Dhafir 
Published: April 2015

AbstractElectrical stimulation has been used as a mode of therapy for a number of clinical conditions. However, it has not been used for the treatment of cutaneous leishmaniasis (CL). For this purpose, we designed the “Baghdadin device”. A total of 146 lesions of acute CL in 54 patients were treated by this device. Twenty‐one lesions in the same patients were left untreated as controls. In addition, 36 lesions in 15 patients were treated with intralesional sodium stibogluconate. Treatment by the Baghdadin device consisted of weekly sessions of 10 minutes of direct current electrical stimulation. The intensity of the direct current ranged between 5 and 15 milliamperes, and the voltage was kept below 40 volts. Of the 146 lesions, 135 (92.5%) showed total clearance or marked improvement in 4–6 weeks time. Approximately 67% of the lesions needed only one or two sessions. Scarring was not observed after resolution. None of the untreated lesions showed any signs of improvement in 6 weeks. Of the lesions treated with sodium stibogluconate, 32 lesions (88.9%) showed total clearance or marked improvement, which was not significantly different from the results with the Baghdadin device.
High Incidence of IgG Antibodies to Phenolic Glycolipid in Non‐Leprosy Patients in India
Authors: Kumar Bhushan , Sinha Raghu , Sehgal Shobha 
Published: April 2015

AbstractPurified phenolic glycolipid (PGL‐1) from Mycobacterium leprae was used to detect IgG antibodies against PGL‐1 in leprosy patients in an enzyme‐linked immunosorbent assay (ELISA). A total of 698 sera were screened; they came from patients suffering from leprosy, autoimmune disease, myeloma, tuberculosis and sexually transmitted diseases (STDs). Cases with miscellaneous diseases and persons undergoing AIDS screening were also included. Sera from lepromatous and tuberculoid leprosy patients gave positivity rates of 60.5% and 41.7%, respectively. In non‐leprosy cases, the PGL‐1 ELISA showed an overall positivity rate of 6.9%; this was greatest in patients with tuberculosis (43.8%) followed by autoimmune diseases (40.9%) and miscellaneous cases including liver diseases (37.9%). This study emphasizes that PGL‐1 ELISA has a low predictive value for diagnosis of active infection by Mycobacterium leprae. Positive reactions in a significant percentage of patients with autoimmune disease are intriguing and need indepth study.
Metastasis of Esophageal Carcinoma Manifesting as Whitlow‐like Lesions
Authors: Umebayashi Yoshihiro 
Published: April 2015

AbstractA rare case of phalangeal metastasis of esophageal carcinoma in an 81‐year‐old man is described. The patient developed a tender, red, and swollen right index finger. From the clinical features, he was erroneously diagnosed with whitlow at first and treated with antibiotics with no success. A bone X‐ray showed that the distal phalanx of the index finger was completely dissolved. Histopathological examination revealed proliferation of squamous cell carcinoma into the deep dermis. It is important to understand that the phalangeal metastases commonly display inflammatory symptoms that mimic acute infection.
Membranous and Soluble Forms of Fas Antigen in Cutaneous Lupus Erythematosus
Authors: Fushimi Misao , Furukawa Fukumi , Tokura Yoshiki , Itoh Taisuke , Shirahama Shigeho , Wakita Hisashi , Takigawa Masahiro 
Published: April 2015

AbstractThe role of Fas‐mediated apoptosis in cutaneous lupus erythematosus (LE) is still unclear, although the Fas/FasL system has been investigated in autoimmune diseases in relation to impaired apoptosis. In order to elucidate the connections between acute cutaneous LE (ACLE) and chronic cutaneous LE (CCLE), we determined the expression of membranous Fas antigen (mFas) on peripheral blood mononuclear cells (PBMC) by flow cytometry and the levels of the soluble form of the Fas antigen (sFas) in sera. The ratio and the mean fluorescence intensity of mFas were much higher in ACLE patients than in others, including patients with CCLE and atopic dermatitis and normal healthy controls. The levels of sFas in ACLE and CCLE patients were also elevated, and there was a significant increase in sFas levels in ACLE patients over that in CCLE patients. Immunohistochemical studies revealed that Fas antigen was predominantly expressed on infiltrating cells around blood vessels and appendages in ACLE and CCLE patients. Based on these findings, it is suggested that the expression of Fas antigen is closely associated with the activation of circulating lymphocytes, especially in ACLE patients, but is not directly associated with keratinocyte damage.
Sarcomatoid Carcinoma of the Skin: Report of a Case
Authors: Ríos‐Martín Juan J. , Parra‐Martín Jose A. , Gómez‐Pascual Amparo , Hevia‐Vázquez Alberto , González‐Cámpora Ricardo 
Published: April 2015

AbstractWe report the histological, immunohistochemical and ultrastructural findings of an exophytic cutaneous tumor composed of a mixture of typical basal cell carcinoma (BCC) and malignant fibrous histiocytoma. Nine previously reported carcinosarcomas of the skin are reviewed. We prefer the term “sarcomatoid carcinoma” for this rare neoplasm. Only the BCC showed a positive immunoreaction to cytokeratin; the sarcomatous component was negative, but it did express vimentin, and, focally, smooth‐muscle‐specific actin and KP1 (CD68). Both components showed p53 immunostaining.
A Case of Rudimentary Meningocele
Authors: Yanagi Toshiaki , Sato Toshihiro , Fuijwara Sakuhei , Takayasu Susumu , Terashi Hiroto , Yokoyama Shigeo 
Published: April 2015

AbstractA 2‐year‐old girl had an alopecic, atrophied macule on the midline of the occipital area. X‐ray and CT scan of the scalp revealed no underlying bone defect. Histologically, the whole dermis and subcutis showed dense, hyalinized collagen bundles intermingled with cuboidal, epithelioid cells that surrounded pseudovascular spaces or gathered in clusters. These flattened or cuboidal cells were positive for anti‐vimentin antibody; some of them were also positive for an anti‐epithelial membrane antigen antibody, but negative for anti‐factor VIII‐related antigen and Ulex europaeus I lectin.
Leopard Syndrome: A Tropical Rarity
Authors: Gupta Piyush , Loiwal Vikas , Rai Rajesh , Baruah M.C. , Mishra Kiran , Krishna Anurag 
Published: April 2015

AbstractThis is a case report of a classical presentation of the Leopard syndrome from the Indian subcontinent. The male patient had progressively increasing generalised multiple lentiginosis, ocular hypertelorism, pulmonary stenosis, short stature, cryptorchidism, and pectus excavatum. The case is documented for its rarity in this part of the world and typical clinical presentation.
Gigantic Pyoderma Gangrenosum
Authors: Ikeda Isamu , Johno Masayoshi , Higashi Shuichi , Ono Tomomichi 
Published: April 2015

AbstractA 71‐year‐old Japanese female with gigantic pyoderma gangrenosum is reported. The pyoderma lesions had been treated as an infectious condition for seventeen months and had extended to enormously large areas. The nature of the chronic type of pyoderma gangrenosum may need to be stressed, even for dermatologists.
Neurotropic Melanoma Invading the Median Nerve
Authors: Iyadomi Minako , Ohtsubo Haruhiko , Gotoh Yumiko , Kohda Hiromu , Narisawa Yutaka 
Published: April 2015

AbstractWe report a case of acral lentiginous melanoma of the right thumbnail bed which demonstrated characteristic intraneural invasion and extension along the median nerve. Four years after amputation of the involved thumb, a melanotic tumor recurred on the right thenar. Radiation therapy was given. The tumor invaded the median nerve, however, causing progressive pain and paralysis of the right hand. Despite right arm amputation, the tumor extensively metastasized, and the patient died three years later.Histopathologically, the tumors were characterized by extensive proliferation of spindle‐shaped cells forming neuroid fascicles especially prominent in the metastatic region. Tumor cells were positive immunohistochemically with S‐100 protein antisera.
Coexistence of Generalized Morphea with Histological Changes in Lichen Sclerosus et Atrophicus and Lichen Planus
Authors: Sawamura Daisuke , Yaguchi Tadashi , Hashimoto Isao , Nomura Kazuo , Konta Ritsuko , Umeki Kaoru 
Published: April 2015

AbstractWe reported a 44‐year‐old Japanese woman with generalized multiple sclerotic plaques, which showed hisological findings of morphea. This patient also had an erosive lesion on her mouth; its histological findings were consistent with lichen planus. A sclerotic lesion on her thigh showed the histological findings of lichen sclerosus et atrophicus (LSA). These data suggest that similar etiologic events or closely related pathologic processes are involved in morphea, lichen planus, and LSA.
Contact Dermatitis Due to Sodium Colistimethate
Authors: Sasaki Satsuki , Mitsuhashi Yoshihiko , Kondo Shigeo 
Published: April 2015

AbstractColistin methanesulfonate sodium (CLMS) is a widely‐used antibiotic. To our best knowledge, only two cases of contact allergy to CLMS have been reported. We described a 4‐year‐old girl with contact dermatitis evoked by CLMS that had been applied as an ophthalmic solution. The dermatitis started after administration for 21 days. The diagnosis was confirmed by as is and constituent patch tests. We reviewed the literature in which contact allergy due to CLMS and colistin sulfate is described.
Management of Female Genital Warts with an Analog of Imiquimod 2% in Cream: A Randomized, Double‐Blind, Placebo‐Controlled Study
Authors: Syed Tanweer A. , Ahmadpour Oliver Abbas , Ahmad Seyed Ali , Ahmad Seyed Hamzeh 
Published: April 2015

AbstractThe purpose of this randomized, double‐blind, placebo‐controlled study was to determine the clinical efficacy and tolerability of an analog of imiquimod (2%) in cream to cure genital warts in women. Sixty preselected women, ranging between 18 and 45 years of age (mean 24.3) and having 411 lesions (mean 6.8) with clinical, histopathological and polymerase chain reaction (PCR) confirmed diagnosis of human papilloma virus (HPV) infection were randomized to two parallel groups. Each patient received a precoded 40‐g tube and instructions on how to apply the trial medication to their lesions at home two times daily for five consecutive days per week. The active treatment period was six weeks. Patients were evaluated on a weekly basis. A clinically and PCR established total clearance of target warts was recorded as a cure. By the end of the treatment, 43.3% of patients and 42.8% of warts were cured. Code disclosure revealed that imiquimod cream had cured 83.3% of the treated patients and 84.3% of the treated warts, while the placebo healed one subject and four warts (p<0.0001). Eight patients (13.3%) in the imiquimod group experienced mild to moderate, non‐objective, drug‐induced symptoms with no dropouts. Among the 26 cured patients, five had a relapse after 11 months. In conclusion, the data presented demonstrate that 2% imiquimod in cream with mild to moderate subjective side effects is significantly more effective than placebo in eliminating genital warts in women.
Solitary Basaloid Follicular Hamartoma
Authors: Toyoda Masahiko , Kagoura Masayori , Morohashi Masaaki 
Published: April 2015

AbstractWe present a case of solitary basaloid follicular hamartoma of 8 years' duration on the nose of a 55‐year‐old Japanese man. Clinical examination revealed a solitary, asymptomatic, smooth‐surfaced, black papule. Histologically, the lesion showed multifocal proliferation of basaloid cells forming islands, branching cords and anastomosing strands that were continuous with the basal layer of the epidermis. Individual hair follicles were replaced by these undifferentiated basaloid proliferating cells. Some abortive hair folliclelike structures composed of follicular bulbs and contiguous rudimentary dermal papillae were observed. This solitary papular type of basaloid follicular hamartoma is quite rare; our case is clearly distinguished from other neoplasms with hair follicle differentiation as well as from infundibulocystic basal cell carcinoma, which have been the most problematic differential diagnoses in the recent dermatopathologic literature.
Sublingual Foregut Cyst
Authors: Kim Yi‐Sun , Ahn Sung Ku , Lee Seung Hun 
Published: April 2015

AbstractForegut cysts are usually found in the mediastinum, the lung, or the wall of the upper gastrointestinal tract, but only rarely at the base of tongue. We report a sublingual foregut cyst in a 27‐year‐old man.
Linear IgA Bullous Dermatosis with Circulating IgG Autoantibodies to the 230 kD Epidermal Antigen
Authors: Honoki Kumiko , Muramatsu Tsutomu , Tsubakimoto Akiko , Shirai Toshihiko 
Published: April 2015

AbstractThe patient was a 54‐year‐old woman with wide‐spread bullous lesions on her trunk and oral mucosa. Histologic examination revealed a subepidermal blister with infiltration of neutrophils and eosinophils. Direct immunofluorescence showed an exclusively IgA deposition at the basement membrane zone (BMZ). Indirect immunofluorescence showed that the blister fluid, but not the serum, contained IgG antibodies against the BMZ antigen on the epidermal side of salt‐split skin. Using immunoblot analysis with normal human epidermal extracts, both serum and blister fluid reacted with the 230 kD epidermal antigen. Using colloidal gold and direct immunoelectron microscopy, IgA deposition was detected in the lamina lucida. Clinically, the skin lesions responded well to dapsone.We diagnosed this case as linear IgA bullous dermatosis (LABD) with IgG class circulating autoantibodies against the epidermal 230 kD antigen. These antibodies were considered to be secondary to the damage to the epidermal basal keratinocyte in this case.
Clinical Phenotype of Bart's Syndrome Seen in a Family with Dominant Dystrophic Epidermolysis Bullosa
Authors: Wakasugi Shoji , Mizutari Kumiko , Ono Tomomichi 
Published: April 2015

AbstractBackground: Bart's syndrome is one type of dominant dystrophic epidermolysis bullosa (EB). It is known that, in some familial cases of dominant dystrophic EB, the symptoms differ depending on the individual. We observed the way Bart's syndrome affected four generations in the same family. The proband was a newborn boy who showed congenital localized absence of skin (CLAS) and bullae on the anterior aspects of both legs. Histologically, the bullae were located subepidermally. The CLAS and bullae disappeared within 4 months after birth, leaving scars. His father retained scarring and scaling from the knees down along the anterior aspect of the legs, and the nails of the toes were either lacking or deformed. His paternal grandmother and great‐grandmother also presented deformed nails of the toes, although they had not had CLAS or bullae on the legs at birth. The individuals in this family thus showed some heterogeneity depending on the sex: blistering and CLAS were seen on the legs soon after birth in the male family members, but the female members did not share this pattern of symptoms, suggesting that the expression of symptoms may differ depending on the sex of the affected individual.
Toxic Epidermal Necrolysis with Severe Gastrointestinal Mucosal Cell Death: A Patient Who Excreted Long Tubes of Dead Intestinal Epithelium
Authors: Sugimoto Yasuko , Mizutani Hitoshi , Sato Takayuki , Kawamura Noriko , Ohkouchi Kumiko , Shimizu Masayuki 
Published: April 2015

AbstractTEN is a severe inflammatory disease which is characterized by generalized epithelial destruction. The epidermis is the most common target of TEN, however, any epithelium can be involved. We report a toxic epidermal necrolysis (TEN) patient who excreted long tubes of dead intestinal epithelium. Epidermal keratinocytes and intestinal epithelium were found to undergo extensive apoptosis by TUNEL method. Drugs were speculated as the causative agents for this case, the causative drug has not been identified. In contrast to marked improvement of cutaneous manifestation and hepatic function by methyl prednisolone pulse therapy, the gastrointestinal symptoms did not respond to therapies, and the patient died by heart failure. Present case suggested a pathogenetic mechanism targeting antigens commonly expressed on the gastrointestinal epithelium and epidermis.
The Discrepancy in Hardness between Clinical and Histopathological Findings in Localized Scleroderma Treated with PUVA
Authors: Yamaguchi Keiko , Takeuchi Izuho , Yoshii Noriko , Gushi Akira , Kanekura Takuro , Kanzaki Tamotsu 
Published: April 2015

AbstractTopical PUVA therapy was applied to a patient with localized scleroderma. Her localized scleroderma responded very well to the topical PUVA therapy, i.e., her sclerotic skin softened to normal skin texture. However, despite this dramatic clinical change the histopathological findings did not change at all and were still “hard”.
HLA Class I and II Alleles and Susceptibility to Generalized Pustular Psoriasis: Significant Associations with HLA‐Cw1 and HLA‐DQB1*0303
Authors: Ozawa Akira , Miyahara Motomi , Sugai Junichi , Iizuka Mariko , Kawakubo Yo , Matsuo Itsuro , Ohkido Muneo , Naruse Taeko , Ando Hitoshi , Inoko Hidetoshi , Kobayashi Hitoshi , Ohkawara Akira , Takahashi Hidetoshi , Iizuka Hajime , Morita Eishin , Yamamoto Shoso , Hide Michihiro , Taniguchi Yoshiki , Shimizu Masayuki 
Published: April 2015

AbstractHLA alleles in generalized pustular psoriasis (GPP) were investigated to clarify the etiology and/or pathogenesis of this disease. Not only serological typing of HLA class I and II antigens but also genotyping of HLA class II alleles were carried out in twenty‐six unrelated Japanese patients with GPP. These patients were classified according to their history of psoriasis vulgaris (PV). Serological typing revealed a significantly high incidence of HLA‐Cw1 (Pc=0.04) in the patients as compared with Japanese healthy controls. The frequency of HLA‐B46 was particularly high in the patients with GPP and a previous history of PV. Genotyping of HLA class II alleles showed a highly significant increase in HLA‐DQB1*0303 (Pc=0.01) in the patients vs. the healthy controls. In particular, HLA‐DQB1*0303 was significantly more frequent in the patients with no prior history of PV than in those with a history of PV. Analysis on linkage disequilibrium showed remarkably different patterns for HLA class II haplotypes between the patients and the healthy controls. Based on the comparative analysis among the amino acid sequences of the β1‐domain of the HLA‐DQB1*03 alleles, proline at residue 55 was suggested to be important as a common amino acid for determination of the susceptibility to GPP. These results revealed not only an association between the etiology and/or pathogenesis of GPP and HLA, but also different mechanisms of the immune response between the patients with GPP and PV.
Peripheral T‐Cell Activation in Non‐Segmental Vitiligo
Authors: Mahmoud Fadia , Abul Habib , Al‐Saleh Qasem , Haines Donald , Burleson Joe , Morgan Gareth 
Published: April 2015

AbstractVitiligo is a hypopigmentary dermatosis of probable autoimmune origin. Previously reported aberrations in peripheral blood mononuclear cells (PBMC), especially T cells and T cell subsets, have been inconsistent. Lymphocyte subpopulations were examined using flow cytometry and monoclonal antibodies against CD4, CD8, CD20, CD25, CD45RA, and HLA‐DR in 34 patients with non‐segmental vitiligo. Twelve patients had not received any previous treatment and 22 had previously received at least one course of PUVA therapy that was discontinued at least four months prior to our study. Compared to matched controls, we found significant increases in CD25 and HLA‐DR in vitiligo patients (p=0.000). An inverse correlation was observed between HLA‐DR and patient status with regard to treatment (p=0.001). These results suggest a role for T cells in the pathogenesis of vitiligo and imply that previous PUVA therapy may be reflected by an alteration in circulating DR + ve cells.
Stevensjohnson Syndrome Caused by a Health Drink (Eberu®) Containing Ophiopogonis Tuber
Authors: Mochitomi Yuji , Inoue Akiyo , Kawabata Hisashi , Ishida Sanemasa , Kanzaki Tamotsu 
Published: April 2015

AbstractStevens‐Johnson syndrome is considered to be a severe type of erythema exsudativum multiforme. It is characterized by erythema with bullous and eroded lesions of skin and mucous membranes. We report a case of Stevenjohnson syndrome following consumption of a health drink containing ophiopogonis tuber. A 66‐year‐old female took an O.T.C. health drink for fever. The next morning, she noted erythema and swelling of her face, neck, and chest. She started to develop bullous and eroded lesions on the skin of her entire body and the mucous membranes of her oral cavity, conjunctiva, and cornea, and she became feverish. She had high degrees of corneal erosion and liver dysfunction. Skin biopsy showed diffuse necrosis of the epidermis. After admission to the hospital, steroid pulse therapy (1000 mg/day of methylprednisolone sodium succinate) was continued for 5 days. The health drink induced a positive drug lymphocyte stimulation test (DLST) and patch test. A challenge test was done with a one hundredth dose, and it was positive. We did patch tests with all components of the drink and found that Mai‐Meu‐Dong‐Tang (ophiopogonis) alone was positive at 72 hours. There is no previous report of Stevens‐Johnson syndrome caused by a health drink or Mai‐Meu‐Dong‐Tang. Even though it is a health drink, we should be aware of the possibility of a severe reaction.