bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micro-Nanostructured Polymeric Scaffolds for Bone Tissue Engineering
Authors: Abdulmalik Sama , Wijekoon Suranji , Danazumi Khadija Basiru , Srinivasan Sai Sadhananth , Vobbineni Laxmi , Obopilwe Elifho , Kumbar Sangamesh G. 
Published: July 2024

While bone tissue allograft and autograft are commonly used in bone healing, their application is limited by factors such as availability, donor site morbidity, and immune response to the grafted tissue. Tissue-engineered implants, such as acellular or cellular polymeric structures, offer a promising alternative, and are a current trend in tissue engineering. Leveraging recent advancements in bone tissue engineering (BTE), we utilize 3D printing to develop biodegradable scaffolds that combine mechanical strength and bioactivity to facilitate bone repair and regeneration. This study focuses on the design and fabrication of mechanically competent 3D printed poly (L-lactic acid) (PLLA) micro-structured scaffolds. These scaffolds are enhanced with collagen type I nanofibrils to create bioactive scaffolds that promote tissue regeneration. The performance of these mechanically competent, micro-nanostructured polymeric matrices, in combination with bone marrow stromal cells (BMSCs), is evaluated in PLLA and PLLA-collagen scaffolds. The resulting micro-nanostructured PLLA-Collagen scaffolds mimic trabecular bone architecture, mechanical strength, and the extracellular matrix environment found in native bone tissue. The composite PLLA-collagen scaffolds exhibit mechanical properties in the mid-range of human trabecular bone. Both PLLA and PLLA-Collagen scaffolds support human BMSCs adhesion, proliferation, and osteogenic differentiation. A significantly higher number of implanted host cells are distributed in the PLLA-Collagen scaffolds with greater bone density, more uniform cell distribution, and attachment compared to the PLLA microstructure. Additionally, the biomimetic collagen nanostructure potently induces osteogenic transcription evidenced by increased alkaline phosphatase activity and upregulation of bone markers such as sialoprotein and collagen type I, ultimately guiding stem cell-mediated formation of a mature, mineralized bone matrix throughout the interconnected scaffold pores. This study underscores the benefits of micro-nanostructured scaffolds in successfully generating the inductive microenvironment of native bone extracellular matrix, triggering the cascade of cellular events required for functional bone regeneration, repairing critical-sized bone defects, and ultimately serving as an alternative material platform for bone regeneration, thereby instilling confidence in the potential of our research.
Botensilimab, an Fc-Enhanced Anti–CTLA-4 Antibody, Is Effective against Tumors Poorly Responsive to Conventional Immunotherapy
Authors: Chand Dhan , Savitsky David A. , Krishnan Shanmugarajan , Mednick Gabriel , Delepine Chloe , Garcia-Broncano Pilar , Soh Kah Teong , Wu Wei , Wilkens Margaret K. , Udartseva Olga , Vincent Sylvia , Joshi Bishnu , Keith Justin G. , Manrique Mariana , Marques Marilyn , Tanne Antoine , Levey Daniel L. , Han Haiyong , Ng Serina , Ridpath Jackson , Huber Olivia , Morin Benjamin , Galand Claire , Bourdelais Sean , Gombos Randi B. , Ward Rebecca , Qin Yu , Waight Jeremy D. , Costa Matthew R. , Sebastian-Yague Alvaro , Rudqvist Nils-Petter , Pupecka-Swider Malgorzata , Venkatraman Vignesh , Slee Andrew , Patel Jaymin M. , Grossman Joseph E. , Wilson Nicholas S. , Von Hoff Daniel D. , Stebbing Justin , Curiel Tyler J. , Buell Jennifer S. , O’Day Steven J. , Stein Robert B. 
Published: July 2024

Abstract
Conventional immune checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) elicit durable survival but primarily in patients with immune-inflamed tumors. Although the mechanisms underlying response to anti–CTLA-4 remain poorly understood, Fc-gamma receptor (FcγR) IIIA coengagement seems critical for activity, potentially explaining the modest clinical benefits of approved anti–CTLA-4 antibodies. We demonstrate that anti–CTLA-4 engineered for enhanced FcγR affinity leverages FcγR-dependent mechanisms to potentiate T-cell responsiveness, reduce intratumoral regulatory T cells, and enhance antigen-presenting cell activation. Fc-enhanced anti–CTLA-4 promoted superior efficacy in mouse models and remodeled innate and adaptive immunity versus conventional anti–CTLA-4. These findings extend to patients treated with botensilimab, an Fc-enhanced anti–CTLA-4 antibody, with clinical activity across multiple poorly immunogenic and ICI treatment–refractory cancers. Efficacy was independent of tumor neoantigen burden or FCGR3A genotype. However, FCGR2A and FCGR3A expression emerged as potential response biomarkers. These data highlight the therapeutic potential of Fc-enhanced anti–CTLA-4 antibodies in cancers unresponsive to conventional ICI therapy.

Significance:
This study reveals that Fc-enhanced anti–CTLA-4 harnesses novel mechanisms to overcome the limitations of conventional anti–CTLA-4, effectively treating poorly immunogenic and treatment-refractory cancers. Our findings support the development of a new class of immuno-oncology agents, capable of extending clinical benefit to patients with cancers resistant to current immunotherapies.
There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study
Authors: Zhong Aifang , Tan Yejun , Liu Yaqiong , Chai Xiangping , Peng Weijun 
Published: July 2024

Background
The association between poor cardiovascular health and cognitive decline as well as dementia progression has been inconsistent across studies. This study used Mendelian randomization (MR) to investigate the causal relationship between Alzheimer disease (AD), circulating levels of total‐tau, and coronary artery disease (CAD).

Methods and Results

This study used MR to investigate the causal relationship between AD or circulating levels of total‐tau and CAD, including ischemic heart disease, myocardial infarction, coronary heart disease, coronary atherosclerosis, and heart failure. The primary analysis used the inverse‐variance weighted method, with pleiotropy and heterogeneity assessed using MR‐Egger regression and the
Q
statistic. The overall results of the MR analysis indicated that AD did not exhibit a causal effect on heart failure (odds ratio [OR], 0.969 [95% CI, 0.921–1.018];
P
=0.209), myocardial infarction (OR, 0.972 [95% CI, 0.915–1.033];
P
=0.359), ischemic heart disease (OR, 1.013 [95% CI, 0.949–1.082];
P
=0.700), coronary heart disease (OR, 1.005 [95% CI, 0.937–1.078];
P
=0.881), or coronary atherosclerosis (OR, 0.987 [95% CI, 0.926–1.052];
P
=0.690). No significant causal effect of CAD was observed on AD in the reverse MR analysis. Additionally, our findings revealed that CAD did not influence circulating levels of total‐tau, nor did circulating levels of total‐tau increase the risk of CAD. Sensitivity analysis and assessment of horizontal pleiotropy suggested that these factors did not distort the causal estimates.

Conclusions
The findings of this study indicate the absence of a direct causal relationship between AD and CAD from a genetic perspective. Therefore, managing the 2 diseases should be more independent and targeted. Concurrently, investigating the mechanism underlying their comorbidity may not yield meaningful insights for advancing treatment strategies.
Conflict Resolution through Indigenous Knowledge Systems
Authors: Abdo Mohammedawol Reshad 
Published: July 2024

Abstract
Indigenous knowledge is the local knowledge that is unique to a given culture or society. It is the basis for local decision-making in agriculture, medicine, food education, environmental management, craft skills, linguistics and conflict management. The study explored mengehacha, an indigenous system of conflict resolution among the Gumuz people in northwest Ethiopia, which aims to restore peace and harmony within the community when conflicts result from natural resource competition, exchange marriage, clan-based conflict and theft. Data was collected through semi-structured interviews, focus group discussions, non-participatory observation and document analysis, and analysed qualitatively. The indigenous mechanisms of conflict resolution were found to be relatively participatory and supplementary to the state justice system. It is recommended that indigenous systems of conflict management be supported and given equal treatment with the modern court system and that exchange marriage be curbed, since it is becoming a trigger for conflict eruption among the Gumuz.
The Identity, Etymology, and Material Context of סֹחֶרֶת in Esther 1:6
Authors: Ayil Ephraim S. 
Published: July 2024

Abstract
The hapax legomenon סֹחֶרֶת (sōḥereth) has eluded identification. Comparison with Ancient Egyptian ṯḥnt “faience, blue chalcedony” is phonologically plausible. “Faience” does indeed match the material evidence of the Susan palace.
Creating Community through Church-based Pollinator Gardening
Authors: Dohe Carrie B. 
Published: July 2024

Abstract
Bees for Peace promotes pollinator protection by establishing blooming feeding sites for bees and other pollinators on the grounds of houses of worship. In Canada, the project’s primary aim was to educate people about native bees, invoking positive feelings that moved people to protect these relatively unfamiliar creatures. To do so, I developed fun, educational games and talks on the cultural history of bees, which I presented at numerous churches in the Greater Toronto Area. Despite ongoing challenges posed by the COVID-19 pandemic, the project and its student researchers were able to partner with two churches to plant pollinator gardens. The educational activities that accompanied the care and maintenance of these gardens resulted in individuals in and around the churches experiencing an expanded sense of community as well as a heightened awareness of native pollinators and the desire to protect them.
“Therefore I Say, Mary”
Authors: Parkhouse Sarah 
Published: July 2024

Abstract
The recently published P.Oxy. 5577 bears such striking similarities to the Gospel of Mary that this article argues that it may be from the missing pages in which Mary recalls her vision of Jesus and their private conversation. By examining the shared themes of cosmology and eschatology, incarnation and divine goodness, baptism and salvation, Jesus appearing as and through the νοῦς, and the privileged role of Mary, this article argues that we see a continuous teaching from the beginning of the extant Coptic Gos. Mary, through the Greek fragments including P.Oxy. 5577, to the end of the gospel. Although P.Oxy. 5577 cannot definitively be identified as Gos. Mary, the correlations are enough to take the suggestion of its likelihood seriously.
Triads, Groups, and the Text of Jude 22–23
Authors: Prothro James B. 
Published: July 2024

Abstract
The text of Jude 22–23 is notoriously difficult and continually disputed. While many now acknowledge the antiquity and external evidence in favor of the shortest, two-clause reading found in 𝔓⁷² and other sources, it is often argued that a longer reading with three clauses (printed in the NA/UBS) has greater intrinsic probability owing to Jude’s triadic style. Recent proponents of the longer reading also argue its plausibility within Jude’s argumentation and the “groups” addressed therein. The present article defends and aims to enhance the probability of the shortest reading on internal grounds. In particular, this article shows that this reading fits Jude’s triadic style and Jude’s call for the “beloved” to exercise mercy on the “disputers” with particular caution.
Social fish use different submission signals depending on spatial position
Authors: Reddon Adam R. , Richardson Christian , Jose Amy , Frommen Joachim G. , Swaney William T. 
Published: July 2024

Abstract
Animals often possess multiple distinct threat signals which indicate their level of aggressive motivation or resource holding potential. In contrast, the diversity of submission signals is considerably lower. Still, some social species exhibit multiple distinct submission signals which could have different strategic functions or serve to enhance signal transmission. In the current study, we examine submission signalling in the daffodil cichlid (Neolamprologus pulcher), a cooperatively breeding fish which produces two distinct submission signals: a tail quiver, and a head-up posture. Observing interactions within stable social groups revealed that submission signal selection depends on the location of the interaction, with tail quivers being preferentially displayed near the substrate, and head-up postures being deployed when the interaction takes place further away from the substrate. Our findings suggest that variation in submission signalling in daffodil cichlids may serve to enhance signal transmission across spatial contexts rather than to convey distinct information.
Vulnerable Group Theory of Financial Inclusion
Authors: Ozili Peterson K. 
Published: July 2024

Abstract
In this article, I propose the vulnerable group theory of financial inclusion. The theory begins with the premise that vulnerable people are often left behind in society, they suffer the most from economic hardship and crises, and they are at risk of being excluded from the formal financial sector. The theory therefore proposes that financial inclusion efforts should be targeted at all vulnerable people and groups in society. Bringing vulnerable people into the formal financial sector will give them access to available formal financial services, which they can use to earn income and acquire assets that they can use to take themselves out of the vulnerability bracket. The study also identifies the vulnerable groups in need of financial inclusion and proposes a vulnerability grid. Several avenues to expand the theory are suggested.
New Hellenistic Coin Finds from the Baysun and Kugitang Piedmonts, Southern Uzbekistan (season 2018)
Authors: Stančo Ladislav , Shaydullaev Shapulat , Militký Jiří , Kmošek Matěj , Bek Tomáš 
Published: July 2024

Abstract
The article presents assemblage of Seleucid and Greco-Bactrian coins found by the Czech-Uzbek archaeological expedition in the frame of a sampling metal detector survey in the upper reaches of Sherabad Darya, from the sites of the Darband Wall, Daganajam, Kurganzol and Iskandar Tepa in 2018. Sixteen specimens, of both silver and copper alloys, which were determined including a very rare Seleukos I (?) coin are assessed not only from the numismatic and historical point of view, but also analysed in terms of elemental composition.
Young Scientists and Model Children
Authors: Brzycki Melissa A. 
Published: July 2024

Abstract
During the Great Leap Forward (1958–1961), the state attempted to rapidly transform the country into a socialist, industrial powerhouse, necessitating the mobilisation of all members of society, including children. This article demonstrates that during the Great Leap Forward in particular, periodicals, storybooks, and newspaper stories portrayed children as independent problem-solvers and political actors, who often acted outside of, and sometimes in defiance of, adult authority. However, during this period, in daily life, teachers, parents, and Young Pioneer counsellors rewarded children for many aspects of the same behaviour as in the early years of the PRC: studying hard, helping one’s classmates, supporting the teacher, doing chores at home, and being kind and obedient to adults and authority figures. Thus, the heroic child of national media and the obedient child of daily life diverged significantly during the Great Leap Forward.
Madness and the Apostle: Paul’s Jewishness in the Euthalian Prologue to the Letters of Paul and in the Writings of John Chrysostom
Authors: Drake Luke 
Published: July 2024

Abstract
The Euthalian Prologue to the Letters of Paul is found in hundreds of late ancient and medieval editions of the Pauline corpus, presenting readers with a prefatory biography of the apostle that both aligns and departs from canonical traditions. Notably, the Prologue depicts Paul’s violence against early Christian assemblies as a manifestation of Jewish μανία, triggered by prophetic foresight and healed by Christ on the road to Damascus. Previous studies primarily examine the Prologue’s connection to canonical sources. This article explores its relationship with other late ancient expressions of Paul’s life. It argues specifically that the Prologue’s depiction of Paul has been shaped – either directly or indirectly – by the writings of John Chrysostom, based on otherwise unique shared thematic elements. Its findings contribute to our understanding of the Prologue’s nebulous origins, its rhetorical objectives, and Chrysostom’s already massive impact on the reception of Pauline literature and tradition in the late ancient and medieval periods.
The Twilight of the Law of the Fairs: Inventing International Cooperation on Bankruptcies in Early Modern Europe (Lyon, 1660–1710)
Authors: Saint-Cast Benoît 
Published: July 2024

Abstract
Bankruptcy was a key institution in the development of markets in Europe. However, the territoriality of jurisdictions and legal systems made international insolvencies difficult to manage. In the middle of the seventeenth century, cities such as Lyon developed networks of cooperation by granting foreign merchants equal rights to local creditors on a reciprocal basis. However, courts were reluctant to give foreign authorities control over assets and creditors on their territory. The article examines how the Lyon commercial court changed its policy towards international insolvencies during the second half of the seventeenth century. Whereas equal treatment of foreign creditors was conditioned on the recognition of an extraterritorial jurisdiction in the medieval fairs system, it now depended on the reciprocity of the legal status granted to merchants abroad. This system of cooperation between equally sovereign courts prefigured in many ways the current situation of private international law in bankruptcy matters.
Argentina’s Commitment to International Criminal Justice to Address the Crimes of the Last Dictatorship (1976–1983)
Authors: Vegh Weis Valeria , Rey Sebastian 
Published: July 2024

Abstract
This article will explain how Argentina developed a strong commitment to international criminal justice to address the crimes of the last dictatorship (1976–1983) that transcended the local dimension and shaped the field globally. In particular, the article will focus on three specific dimensions: the disputes surrounding the concept of ‘dirty war’ in relation to the crimes committed in the 1970s and how its legal conceptualisation has evolved over time; how domestic courts have applied international and domestic criminal law to judge these crimes and how this has changed over time; and, finally, what was the role of human rights organisations in fostering the accountability process.
The Contribution of the European Court of Human Rights to the Construction of a Corruption-Free Society
Authors: Oriolo Anna 
Published: July 2024

Abstract
Corruption is a serious threat to the stability and security of societies, undermining institutions and democratic values, ethical principles, and justice, as well as sustainable development and the rule of law. It manifests itself in many ways and in a multitude of contexts, affecting almost all human rights, including economic and social rights (i.e., the right to work, the right to food, the right to housing, the right to health, the right to education, the right to public services, the right to development), as well as civil and political rights (i.e., the right to equality and non-discrimination, the right to political participation, the right to an effective remedy and to a fair trial). In this perspective, starting from an examination of the direct and negative impact of corruption on the enjoyment of human rights (Section 1), the analysis that follows focuses on the obligations of States to respect, promote, and above all, protect human rights (i.e., take all necessary measures to ensure their full enjoyment) (Section 2), traces the ECtHR’s most incisive pronouncements on violations of individual guarantees in the context of corruption (Section 3), and highlights the crucial role of the Court’s case law in defining more effective, preventive, and punitive measures against corruption (Section 4).
Healing the Incurable? Pentecostal Prayer Camps and Healing of Chronic Illnesses in Ghana
Authors: Benyah Francis Ethelbert Kwabena 
Published: July 2024

Abstract
Healing is one of the distinctive features of the Pentecostal movement. In Pentecostal missiology healing is fundamental and is geared towards the transformation of the human person and society. Healing thus encompasses both physical and spiritual ailments. It also concerns the healing of unjust structures of society – inequality, corruption, bad governance, and so on. In this article I examine some of the plausible factors that make persons living with chronic illnesses go to prayer camps in search of solutions for their illnesses. The article highlights how prayer camps in Ghana help those living with chronic illnesses negotiate their sense of self and identity in the midst of persistent illness. It argues that in a situation where healthcare systems cannot provide a cure for an illness, people identify with and rely on religious institutions and their resources such as those the prayer camps produce for support, meaning, and enhancement.
Missional Masculinities in Pentecostalism in Africa
Authors: Kaunda Chammah J. 
Published: July 2024

Abstract
The article argues for missional masculinities from an incarnational framework as the foundation for imitatio Christi among Pentecostal men in Africa. It suggests that since masculinities are defined by societal ideals that men are expected to embody, Pentecostal men should reclaim the divine vision of the new ‘manity’ in Christ. Here, Christ serves not only as the epitome of new humanity but also as the exemplar, setting the standard and modeling what it means to be human. Jesus is the primordial model, the definition, the determination, the illustration, and most importantly, the beginning and the end of what it means to be human. Therefore, missional masculinities, modeled after Christ, are primed to exhibit kenotic, relational, agapeic, redemptive characteristics, and are everyday prophetic performances of abundant life for humanity and creation.
A Sonic Vaccine for a White-Collar Disease
Authors: Lorea Carola 
Published: July 2024

Abstract
Members of the Matua religion, a displaced Dalit community from Bengal, believe that the coronavirus can affect only the upper-caste/class layers of society, those who sit in air-conditioned offices and live in the big cities. Matua devotees, on the other hand, are predominantly part of an agriculturist community inhabiting multiple fringes: the borderlands of India and Bangladesh, the peripheries of unorthodox Vaishnavism, and the social margins of untouchability. Conducting remote ethnography with Matua participants based in West Bengal, Bangladesh, and the Andamans, one comes across insistent narratives of immunity and recurrent interpretations of the pandemic that fit into the onto-cosmology and sociocultural imagination of the Matua religious movement. I discuss these as dissident tales of immunity that describe COVID-19 as an urban-based white-collar disease. Matua practitioners successfully prevent it through a sonic vaccine – the practice of kīrtan – and a kind of power (śakti) accumulated through physical agricultural labor.