bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harm to children from others' drinking: A survey of caregivers in Australia
Authors: Hopkins Cassandra , Kuntsche Sandra , Dwyer Robyn , Anderson‐Luxford Dan , Laslett Anne‐Marie 
Published: August 2024

AbstractAimsThis study aimed to identify the prevalence and types of harm to children from others' drinking in Australia, as indicated by caregivers, and examine socio‐demographic characteristics of caregivers who indicated a child was affected by others' drinking.Design, setting, participants and measurementsA subsample of 854 adult respondents, who were caregivers of children under 18 years from the 2021 Australian Alcohol's Harm to Others study, were asked questions about whether children in their care had been negatively affected by others' drinking in the past year. Weighted prevalence estimates of overall and specific harms to children are presented. Logistic regressions were conducted to determine characteristics associated with indicating harms to children from others' drinking.FindingsOver 17% of caregivers (95% confidence interval [CI] = 13.0–19.0) indicated that one or more children in their care had been affected by others' drinking in the past 12 months. Verbal abuse (6.2%; 95% CI = 4.3–8.3) was the most common harm indicated, followed by financial harm (4.3%; 95% CI = 2.7–6.2). One percent of caregivers (95% CI = 0.4–2.3) indicated a child was physically hurt and less than 1% (95% CI = 0.2–1.4) indicated a child was the subject of a child protection call due to someone's drinking. Women and caregivers over 65 years were more likely to indicate a child had been affected compared with men and caregivers under 65 years. Caregivers who drank five or more drinks at least three times per week were four times more likely to indicate a child was affected compared with abstainers. Living in a household with someone who drinks heavily and who had negatively affected the child's caregiver was associated with an increased likelihood of child harm.ConclusionsIn 2021, a weighted survey estimate for caregivers in Australia indicated that almost one in six children had been affected by others' drinking. Heavier drinking of caregivers and other household members was the most substantial predictor for indicating a child had been negatively affected by others' drinking.
Class differences in gratitude and entitlement drive response to COVID‐19 measures
Authors: Wang Yang , Ding Yi , Xie Xiaona , Guo Yongyu 
Published: August 2024

AbstractOwing to the COVID‐19 pandemic, strict government interventions in China have been implemented for more than 3 years as of 2023. How do people of high or low social class respond to the prolonged COVID‐19 measures? Recent evidence has yielded inconsistent conclusions. In this study, we move beyond such debate and focus on the underlying motives that are closely related to both social class and COVID‐19 measure responses. Using a large Chinese sample (N = 1193, 48.50% women, Mage = 30.92 years, SD = 6.08), we found that participants with higher (vs. lower) social class, whether subjective or objective, reported greater gratitude, which in turn increased their willingness to support COVID‐19 measures (i.e. greater public health support and self‐prevention behaviour, and less pandemic burnout). However, those with higher (vs. lower) subjective social class also reported more psychological entitlement, which decreased their willingness to support COVID‐19 measures (i.e. less public health support and greater pandemic burnout). These findings contribute to a nuanced understanding of how social class may influence people's response to COVID‐19 measures.
Does knowledge matter? How a target's knowledge of their COVID‐19 infection during a violation of preventive policies affects perceived immorality and dehumanization
Authors: Tian Qirui , Pan Yuchen , Trémolière Bastien , Becker Maja 
Published: August 2024

AbstractDuring the COVID‐19 pandemic, behaviours that violated various precautionary policies were recurring. The present research examined how Chinese participants' perception of targets in terms of immorality and dehumanization depends on the target's knowledge of their COVID‐19 infection. In Study 1 (N = 223), we manipulated the presentation of the target's knowledge of their COVID‐19 infection before violating policies and observed that a target who knew they were infected was perceived as more immoral and less human than a target who knew they were not infected. In Study 2 (N = 267), we replicated this effect and further observed that a target was perceived as less moral and human even when they did not acquire knowledge of their COVID‐19 infection until after having violated the policies. Moreover, perceived immorality played a mediating role between the target's knowledge of their COVID‐19 infection and dehumanization, which was moderated by risk perception of COVID‐19 in Study 2, but not by fear of COVID‐19 in Study 1. These findings increase our understanding of the phenomenon of moralization in the context of a pandemic.
Oncological treatments have limited effects on the fertility prognosis in testicular cancer: A systematic review and meta‐analysis
Authors: Pape Janna , Fernando Jancy , Megaritis Dimitrios , Weidlinger Susanna , Vidal Angela , Birkhäuser Frédéric D. , Karrer Tanya , von Wolff Michael 
Published: August 2024

AbstractBackgroundTesticular cancer is the most common solid tumour among young men in the reproductive phase. After completing cancer treatment, up to 77% of cancer survivors report an interest in paternity after completing cancer treatment. To preserve fertility, most guidelines recommend that physicians should counsel their patients about sperm cryopreservation before initiating gonadotoxic therapy. However, few studies have assessed fertility parameters after testicular cancer therapies over the last 20 years.ObjectivesTo close the gap of data regarding gonadotoxicity of testicular cancer therapies to enable more accurate counselling regarding fertility preservation.Materials and methodsA systematic literature search was conducted in Medline, Embase and Cochrane until December 2022. The systematic review included studies of men who had undergone all types of unilateral testicular cancer treatment, whereas the meta‐analysis excluded studies with unspecified treatments, less than 10 patients for outcome evaluation or rare tumours. Infertility (i.e. azoospermia, failure to achieve paternity or the usage of cryosperm) was defined as outcome.ResultsThe qualitative analysis included 30 studies with a total of 13,718 men after unilateral testicular cancer. Treatment comprised active surveillance after unilateral orchidectomy (32.7%), radiotherapy (23.1%), standard‐ or low‐dose chemotherapy (33.7%) and high‐dose chemotherapy (1.4%). Post‐treatment spermiograms were analysed in 17 studies. The quantitative synthesis included 23 studies, revealing an overall pooled prevalence of infertility (95% CI) of 14% (9%–21%). Azoospermia occurred in 8% (6%–12%). For good‐prognosis patients who received standard therapy, the overall prevalence of infertility was only 4% (2%–10%).ConclusionSo far, this very first meta‐analysis of overall infertility prevalence provides the best approximation of fertility prognosis for men who have undergone testicular cancer therapy. Despite the low prevalence of infertility, it is still recommended to undergo sperm cryopreservation because of the uncertainty of the subsequent therapy and the lack of large longitudinal data on individual treatment effects.
Novel and recurrent hemizygous variants in BCORL1 cause oligoasthenoteratozoospermia by interfering transcription
Authors: Wang Yu , Xiang Mingfei , Zhou Yiru , Zheng Na , Zhang Jingjing , Zha Xiaomin , Duan Zongliu , Wang Fengsong , Zhang Ying , Wang Zhongxin , Cao Yunxia , Zhu Fuxi 
Published: August 2024

AbstractBackgroundOligoasthenoteratozoospermia (OAT) is a common cause of male infertility, of which the causes remain largely unknown. Recently, BCORL1 was identified as a contributor to male infertility from non‐obstructive azoospermia (NOA) to OAT.ObjectivesTo identify novel and hotspot variants in BCORL1 from infertile men with OAT and reveal their outcomes of assisted reproductive treatments (ARTs).Materials and methodsForty‐six infertile men characterized by OAT were recruited from 2017 to 2022. Variants in OAT patients were identified by whole‐exome sequencing (WES) and verified by Sanger sequencing. Papanicolaou staining was used for sperm morphology analysis. Pathogenicity of BCORL1 variants were analyzed by bioinformatics analysis, and further confirmed in vitro by using recombinant plasmids and cells. Meanwhile, ARTs were performed on these patients to investigate the appropriate clinical treatment strategy.ResultsWe identified a novel hemizygous missense variant (NM_021946: c.G4171A; p.G1391R) and a recurrent variant (NM_021946: c.T2615G; p.V872G) in BCORL1 from four OAT patients. Notably, routine semen assessment and Papanicolaou staining revealed a special OAT phenotype of patients with BCORL1 variants, whose rare mature sperm characterized by acephalic and abnormal acrosome. Pathogenicity analysis showed the interaction between BCORL1 with histone deacetylases (HDACs) were disrupted after variance, accompanied with epigenetic alterations and finally the orderly transcriptions of spermatogenetic genes were interfering. Besides, clinical record presented the poor outcomes of ARTs in these patients with BCORL1 variants.Discussion and conclusionsOur findings further expand the variant spectrum of BCORL1 related to OAT, and provide new evidences that BCORL1 acts as an important transcriptional regulator, participating in epigenetic regulation and directing the expression of key genes throughout spermatogenesis. The outcomes of ARTs will facilitate the genetic counseling and clinical treatment of infertile men with BCORL1 variants in the future.
Embraced: On hands and nerves
Authors: Manderson Lenore 
Published: August 2024

AbstractIn 2001, I experienced severe radial neuropathy, leading to permanent dysfunctions in the fingers of my left hand. In this personal account of nerve damage, medical and surgical treatment, and adaptation, I first describe the sequence of neuropathies, then turn to how through serendipity, the brace enabled other connections—nervelines—with individuals and places. The brace is a metonym of a severed nerve with its associated loss of movement and capacity; it is also both a functional orthotic and an affordance. It carries me forward, activating other nervelines and networks to make things happen. I write of literal and metaphoric nerves, evolving connectivities, and fiber lines, thought lines and collaborations. I then extend the idea of nervelines and networks to global connnections; I emphasize how the organization of labor, the distribution of goods and services, and the expectations of workers shape body histories and life outcomes.
Active components and mechanisms of action of psychological interventions in bipolar disorder: A systematic literature review
Authors: Serbetci Duygu , Koh Zhao Hui , Murray Greg , Tremain Hailey 
Published: August 2024

AbstractObjectiveThe efficacy of psychological interventions for bipolar disorder (BD) is well established, but much remains unknown about how change occurs. The primary objective of this exploratory study was to audit what is known about active components and mechanisms of action of psychological interventions for BD.MethodWe conducted a systematic review (PROSPERO CRD42022323276). Two independent reviewers screened references from four databases and extracted data from eligible studies.ResultsWe included four component studies, six studies with mediation analyses and 26 studies presenting subjective experiences of how psychological interventions bring change. Ten mediators were examined across six studies, with only one putative mediator, medication adherence, tested in more than one study. Some initial support for mediation of varied outcomes by control over thoughts, positive non‐verbal behaviour, self‐esteem, post‐trauma growth and medication adherence. Some preliminary support was found in two components, human support and IPT. Studies exploring participant experiences of therapeutic change enumerated a range of potential active components, mechanisms of action and contextual factors potentially warranting investigation in future research. However, the evidence base for active components and mechanisms of action in psychological interventions for BD is unsatisfactory. Findings were inconsistent, studies homogenous with significant methodological limitations and statistical approaches failed to meet quality criteria.ConclusionsPreliminary identification of potential components and mechanisms via qualitative analyses and the insights emerging from this review will inform future research aimed at investigating how psychological interventions work in BD.
In vitro assessment of cementation of CAD/CAM fabricated prostheses over titanium bases. A systematic review
Authors: Ntovas Panagiotis , Ladia Ourania , Pachiou Aspasia , Fehmer Vincent , Sailer Irena 
Published: August 2024

AbstractObjectivesThe objective of this study is to investigate the outcomes of clinically relevant laboratory studies regarding the cementation of implant‐supported restorations over ti‐bases.Materials and MethodsThe present study has been conducted according to PRISMA statement. An electronic search was performed, including publications up to March 2024, to identify studies investigating the parameters affecting the cementation between ti‐bases and CAD/CAM prostheses. An assessment of the internal validity was performed, using a custom‐made risk of bias tool (QUIN).ResultsFrom the included studies, 40.1% were reported on luting systems, 25% on ti‐base surface treatment, 25% on restoration surface, 21.8% on restoration material, and 18.7% on ti‐base height. The majority of the included studies were associated with a medium risk of bias. In the absence of micro‐retentive features, air‐abrasion of ti‐bases with a minimum height of 3.5 mm can be beneficial for restoration's retention. The bonding performance can vary not only between different bonding systems but also for different applications within the same system, based on a restoration's material and surface treatment as well as on ti‐base height and surface treatment.ConclusionsThe height of the ti‐base seems to be the prevailing factor as it constitutes the prerequisite for other modifications of the bonding surfaces to have an advantageous effect. Since the parameters that can affect bonding performance between ti‐base and restoration can interact with each other, it is important for the clinician to focus on verified bonding protocols.
Resting‐state functional connectivity of the occipital cortex in different subtypes of Parkinson's disease
Authors: Lan Yina , Yuan Hongjun , Ma Xiaoxaio , Yin ChunYu , Liu Xinyun , Zeng XiYu , Lyu Jinhao , Xiong Yongqin , Zhang Xiaobo , Lu Haoxuan , Zhong Yujue , Li Xuemei , Cui Zhiqiang , Lou Xin 
Published: August 2024

AbstractAimsTo examine whether functional connectivity (FC) of the occipital gyrus differs between patients with Parkinson's disease (PD) motor subtypes and healthy controls (HCs).MethodsWe enrolled 30 PD patients exhibiting tremor dominance (TD), 43 PD patients with postural instability and gait disturbance (PIGD), and 42 HCs. The occipital gyrus was partitioned into six areas of interest, as seed points, via the Anatomical Automatic Labeling template to compare the FC of the three groups and analyze the relationship of FC with clinical scales.ResultsCompared with the PIGD group, the TD group showed increased FC between the left superior occipital gyrus (SOG.L) and right median cingulate and paracingulate gyri (DCG.R)/right paracentral lobule/bilateral inferior parietal, but supramarginal and angular gyri; the left middle occipital gyrus (MOG.L) and left posterior cingulate gyrus (PCG.L); the MOG.R and SOG.L/right calcarine fissure and surrounding cortex/DCG.R/PCG.L/right cuneus; the left inferior occipital gyrus (IOG.L) and right caudate nucleus; and the IOG.R and PCG.L.ConclusionDifferentiated FC between the occipital gyrus and other brain areas within the PD motor subtypes, which may serve as neural markers to distinguish between patients with TD and PIGD PD.
Hand eczema in Italian patients referred for patch testing: A retrospective SIDAPA study (2016–2023)
Authors: Stingeni Luca , Napolitano Maddalena , Hansel Katharina , Foti Caterina , Corazza Monica , Borghi Alessandro , Gallo Rosella , Patruno Cataldo , Schena Donatella , Lauriola Maria Michela , Casciola Gabriele , Giuffrida Roberta , Guarneri Fabrizio ,   SIDAPA Study Group
Published: August 2024

AbstractBackgroundHand eczema (HE) is a common skin disease with a negative impact on patients' quality of life in occupational and non‐occupational settings. Up‐to‐date, data on HE in Italian patients referred for patch testing are lacking.ObjectivesTo characterise the profile in terms of demographics, aetiology and patch test results of Italian patients affected by HE referred for patch testing.MethodsA retrospective descriptive study on consecutive patients affected by HE who underwent patch testing from 2016 to 2023 in eight dermatology clinics was performed. HE patients were divided into two groups according to the exclusive (HE‐only group) and not‐exclusive (HE+ group) hand involvement, and compared to patients with eczema localised in body areas other than hands (NHE group).ResultsOne thousand five hundred and ninety‐seven patients were affected by HE (35.3% males; mean age 42.7 years), 60.2% belonging to the HE‐only group and 39.8% to the HE+ group. Occupational dermatitis was diagnosed in 33.2% of HE‐only patients, 25.0% of HE+ patients and 5.2% of NHE patients (p < 0.001). HE‐only patients presented: Allergic Contact Dermatitis (ACD), Irritant Contact Dermatitis (ICD), atopic HE in 48.1%, 47.5% and 7.1%, respectively; hyperkeratotic palmar, acute recurrent vesicular and nummular clinical subtypes in 52.2%, 43.9% and 11.9%, respectively; relevant positive patch test reactions in 48.1% (nickel sulphate 18.9%, methylchloroisothiazolinone/methylisothiazolinone 10.6%, methylisothiazolinone 8.6%, p‐phenylenediamine 6.0% and potassium dichromate 4.7%).ConclusionsHE patients, and particularly those with exclusive hand involvement, show a particular profile in terms of demographic and clinical characteristics, etiologies and relevant positive patch test reactions.
The intellectual base and research fronts of IL‐18: A bibliometric review of the literature from WoSCC (2012–2022)
Authors: Wang Zhongzhi 
Published: August 2024

AbstractInterleukin‐18 (IL‐18) is a vital pro‐inflammatory cytokine crucial for immune regulation. Despite its significance, bibliometric analysis in this field is lacking. This study aims to quantitatively and qualitatively assess IL‐18 research to construct its intellectual base and predict future hotspots. We conducted a thorough search on the Web of Science Core Collection for relevant publications between 1 January 2012 and 31 December 2022. English‐language articles and reviews were included. Visual analysis was performed using various tools including VOSviewer, Citespace, and Microsoft Excel. Our analysis covers interleukin‐18 (IL‐18) literature from 2012 to 2022, exploring research trends comprehensively. Key institutions like Yale University and Shanghai Jiao Tong University emerged as significant contributors. Prolific authors such as Kanneganti and Dinarello made notable contributions. Main focus areas included biology, medicine, and immunology. Co‐citation analysis highlighted influential works like Jianjin Shi. Hotspot keyword frequency cluster analysis revealed emerging themes like pyroptosis and psoriasis. Gene co‐occurrence clustering identified genes associated with immune regulation and inflammation. GO and KEGG pathway enrichment analysis provided insights into IL‐18‐related biological processes and pathways. Protein–protein interaction networks identified core proteins such as IL10 and TNF. Association disease analysis linked IL‐18 to various inflammatory, autoimmune, and metabolic disorders. This bibliometric review offers insights into IL‐18 research trends over the past decade, guiding future investigations and serving as a reference for researchers in this field.
S2k guideline lipedema
Authors: Faerber Gabriele , Cornely Manuel , Daubert Constance , Erbacher Gabriele , Fink Jodok , Hirsch Tobias , Mendoza Erika , Miller Anya , Rabe Eberhard , Rapprich Stefan , Reich‐Schupke Stefanie , Stücker Markus , Brenner Erich 
Published: August 2024

SummaryThis S2k guideline was developed on the initiative and under the German Society of Phlebology and Lymphology (DGPL) leadership. The guideline aims to optimize the diagnosis and treatment of lipedema. It is intended to bring together the different approaches of the respective professional groups in a consensus‐based manner and thus offer a basic concept for the best possible treatment of patients with lipedema. Sixty recommendations were formulated and agreed on in diagnostics, conservative and surgical treatment options, psychosocial factors and self‐management. The guideline is intended to reflect the current scientific knowledge and be widely used for diagnosis and treatment recommendations for patients with lipedema.In particular, the guideline comments on diagnostic criteria, differential diagnoses, and coinciding clinical pictures, their influence on diagnosis and treatment, sensible treatment measures, and self‐management options. The lipedema guideline summarizes the current national and international evidence and the German expert consensus and derives recommendations for the best treatment for patients with lipedema. The recommendations in the guideline are intended as an orientation aid in the sense of action and decision‐making corridors from which deviations are possible in justified cases.
Olfactory facilitation of visual categorization in the 4‐month‐old brain depends on visual demand
Authors: Kiseleva Anna , Rekow Diane , Schaal Benoist , Leleu Arnaud 
Published: August 2024

AbstractTo navigate their environment, infants rely on intersensory facilitation when unisensory perceptual demand is high, a principle known as inverse effectiveness. Given that this principle was mainly documented in the context of audiovisual stimulations, here we aim to determine whether it applies to olfactory‐to‐visual facilitation. We build on previous evidence that the mother's body odor facilitates face categorization in the 4‐month‐old brain, and investigate whether this effect depends on visual demand. Scalp electroencephalogram (EEG) was recorded in two groups of 4‐month‐old infants while they watched 6‐Hz streams of visual stimuli with faces displayed every 6th stimulus to tag a face‐selective response at 1 Hz. We used variable natural stimuli in one group (Nat Group), while stimuli were simplified in the other group (Simp Group) to reduce perceptual categorization demand. During visual stimulation, infants were alternatively exposed to their mother's versus a baseline odor. For both groups, we found an occipito‐temporal face‐selective response, but with a larger amplitude for the simplified stimuli, reflecting less demanding visual categorization. Importantly, the mother's body odor enhances the response to natural, but not to simplified, face stimuli, indicating that maternal odor improves face categorization when it is most demanding for the 4‐month‐old brain. Overall, this study demonstrates that the inverse effectiveness of intersensory facilitation applies to the sense of smell during early perceptual development.Research Highlights
Intersensory facilitation is a function of unisensory perceptual demand in infants (inverse effectiveness).
This inverse relation between multisensory and unisensory perception has been mainly documented using audiovisual stimulations.
Here we show that olfactory‐to‐visual facilitation depends on visual demand in 4‐month‐old infants.
The inverse effectiveness of intersensory facilitation during early perceptual development applies to the sense of smell.