bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finding the Factors of Reduced Genetic Diversity on X Chromosomes of Macaca fascicularis: Male-Driven Evolution, Demography, and Natural Selection
Authors: Osada Naoki , Nakagome Shigeki , Mano Shuhei , Kameoka Yosuke , Takahashi Ichiro , Terao Keiji 
Published: September 2013

Abstract
The ratio of genetic diversity on X chromosomes relative to autosomes in organisms with XX/XY sex chromosomes could provide fundamental insight into the process of genome evolution. Here we report this ratio for 24 cynomolgus monkeys (Macaca fascicularis) originating in Indonesia, Malaysia, and the Philippines. The average X/A diversity ratios in these samples was 0.34 and 0.20 in the Indonesian–Malaysian and Philippine populations, respectively, considerably lower than the null expectation of 0.75. A Philippine population supposed to derive from an ancestral population by founding events showed a significantly lower ratio than the parental population, suggesting a demographic effect for the reduction. Taking sex-specific mutation rate bias and demographic effect into account, expected X/A diversity ratios generated by computer simulations roughly agreed with the observed data in the intergenic regions. In contrast, silent sites in genic regions on X chromosomes showed strong reduction in genetic diversity and the observed X/A diversity ratio in the genic regions cannot be explained by mutation rate bias and demography, indicating that natural selection also reduces the level of polymorphism near genes. Whole-genome analysis of a female cynomolgus monkey also supported the notion of stronger reduction of genetic diversity near genes on the X chromosome.
Impact of the 2004 Tsunami on Self-Reported Physical Health in Thailand for the Subsequent 2 Years
Authors: Isaranuwatchai Wanrudee , Coyte Peter C. , McKenzie Kwame , Noh Samuel 
Published: September 2013

Objectives. We examined self-reported physical health during the first 2 years following the 2004 tsunami in Thailand. Methods. We assessed physical health with the revised Short Form Health Survey. We evaluated 6 types of tsunami exposure: personal injury, personal loss of home, personal loss of business, loss of family member, family member’s injury, and family’s loss of business. We examined the relationship between tsunami exposure and physical health with multivariate linear regression. Results. One year post-tsunami, we interviewed 1931 participants (97.2% response rate), and followed up with 1855 participants 2 years after the tsunami (96.1% follow-up rate). Participants with personal injury or loss of business reported poorer physical health than those unaffected (P < .001), and greater health impacts were found for women and older individuals. Conclusions. Exposure to the tsunami disaster adversely affected physical health, and its impact may last for longer than 1 year, which is the typical time when most public and private relief programs withdraw.
Environmental Conditions in Low-Income Urban Housing: Clustering and Associations With Self-Reported Health
Authors: Adamkiewicz Gary , Spengler John D. , Harley Amy E. , Stoddard Anne , Yang May , Alvarez-Reeves Marty , Sorensen Glorian 
Published: September 2013

Objectives. We explored prevalence and clustering of key environmental conditions in low-income housing and associations with self-reported health. Methods. The Health in Common Study, conducted between 2005 and 2009, recruited participants (n = 828) from 20 low-income housing developments in the Boston area. We interviewed 1 participant per household and conducted a brief inspection of the unit (apartment). We created binary indexes and a summed index for household exposures: mold, combustion by-products, secondhand smoke, chemicals, pests, and inadequate ventilation. We used multivariable logistic regression to examine the associations between each index and household characteristics and between each index and self-reported health. Results. Environmental problems were common; more than half of homes had 3 or more exposure-related problems (median summed index = 3). After adjustment for household-level demographics, we found clustering of problems in site (P < .01) for pests, combustion byproducts, mold, and ventilation. Higher summed index values were associated with higher adjusted odds of reporting fair–poor health (odds ratio = 2.7 for highest category; P < .008 for trend). Conclusions. We found evidence that indoor environmental conditions in multifamily housing cluster by site and that cumulative exposures may be associated with poor health.
Taxing Junk Food to Counter Obesity
Authors: Franck Caroline , Grandi Sonia M. , Eisenberg Mark J. 
Published: September 2013

We examined the advantages and disadvantages of implementing a junk food tax as an intervention to counter increasing obesity in North America. Small excise taxes are likely to yield substantial revenue but are unlikely to affect obesity rates. High excise taxes are likely to have a direct impact on weight in at-risk populations but are less likely to be politically palatable or sustainable. Ultimately, the effectiveness of earmarked health programs and subsidies is likely to be a key determinant of tax success in the fight against obesity.
Medicaid Expansion Initiative in Massachusetts: Enrollment Among Substance-Abusing Homeless Adults
Authors: Zur Julia , Mojtabai Ramin 
Published: September 2013

Objectives. We assessed whether homeless adults entering substance abuse treatment in Massachusetts were less likely than others to enroll in Medicaid after implementation of the MassHealth Medicaid expansion program in 1997. Methods. We used interrupted time-series analysis in data on substance abuse treatment admissions from the Treatment 0Episode Data Set (1992–2009) to evaluate Medicaid coverage rates in Massachusetts and to identify whether trends differed between homeless and housed participants. We also compared Massachusetts data with data from 17 other states and the District of Columbia combined. Results. The percentage of both homeless and housed people entering treatment with Medicaid increased approximately 21% after expansion (P = .01), with an average increase of 5.4% per year over 12 years (P = .01). The increase in coverage was specific to Massachusetts, providing evidence that the MassHealth policy was the cause of this increase. Conclusions. Findings provide evidence in favor of state participation in the Medicaid expansion in January 2014 under the Affordable Care Act and suggest that hard-to-reach vulnerable groups such as substance-abusing homeless adults are as likely as other population groups to benefit from this policy.
Secondhand Smoke Exposure and Smoking Behavior Among Young Adult Bar Patrons
Authors: Kalkhoran Sara , Neilands Torsten B. , Ling Pamela M. 
Published: September 2013

Objectives. We described frequency of secondhand smoke (SHS) exposure among young adults patronizing bars and associations between SHS exposure, attitudes, and smoking behavior. Methods. We collected cross-sectional surveys from randomized time–location samples of bar patrons aged 18 to 26 years in San Diego, California, and Oklahoma City and Tulsa, Oklahoma, in 2010 to 2011. Multivariate logistic regression evaluated associations between SHS exposure, attitudes about dangers of SHS, susceptibility to smoking initiation among nonsmokers, and quit attempts among current smokers. Results. More than 80% of respondents reported past 7-day exposure to any SHS, and more than 70% reported exposure at a bar. Current smokers reported more SHS exposure in cars and their own homes than did nonsmokers. Among nonsmokers, SHS exposure was associated with susceptibility to initiation, but those who believed that SHS exposure is harmful were less susceptible. Belief that SHS is dangerous was associated with quit attempts among smokers. Conclusions. Smoke-free environments and education about the harms of SHS may decrease tobacco use among young adults who frequent bars, where they are heavily exposed to SHS.
Modern Cholera in the Americas: An Opportunistic Societal Infection
Authors: Cerda Rodrigo , Lee Patrick T. 
Published: September 2013

In the Americas, the only two cholera epidemics of the past century have occurred in the past 25 years. Lessons from the 1991 Peruvian cholera epidemic can help to focus and refine the response to the current Haitian epidemic. After three years of acute epidemic response, we have an opportunity to refocus on the chronic conditions that make societies vulnerable to cholera. More importantly, even as international attention wanes in the aftermath of the earthquake and acute epidemic, we are faced with a need for continued and coordinated investment in improving Haiti’s structural defenses against cholera, in particular access to improved water and sanitation.
Influence of active reminders on oral hygiene compliance in orthodontic patients
Authors: Eppright Matthew , Shroff Bhavna , Best Al M. , Barcoma Elvi , Lindauer Steven J. 
Published: September 2013

ABSTRACTObjective:To determine if text message reminders regarding oral hygiene compliance have an influence on the level of compliance within an orthodontic population.Materials and Methods:In this prospective, randomized, controlled clinical trial, 42 orthodontic patients were assigned to a text message or control group. Parents of patients assigned to the text message group received a reminder text message one weekday each week. Oral hygiene compliance was measured using bleeding index (BI), modified gingival index (MGI), and plaque index (PI), and visual examination of white spot lesion (WSL) development at baseline (T0), two appointments after baseline (T1), and four appointments after baseline (T2).Results:BI, MGI, and PI scores were significantly lower in the text message group than in the control group at T2.Conclusion:A text message reminder system is effective for improving oral hygiene compliance in orthodontic patients.
Prediction of Retinopathy at 20 Years After Onset in Younger-Onset Type 1 Diabetes Using Mean Metabolic Memory-Free HbA1c Values
Authors: Hirose Akira , Furushima Daisuke , Yamaguchi Naohito , Kitano Shigehiko , Uchigata Yasuko 
Published: September 2013

OBJECTIVE
Metabolic memory, in which past hyperglycemia could affect future retinopathy, is a potential issue in studying the relationship between glycemia and retinopathy. We examined retrospectively if mean “metabolic memory-free” glycosylated hemoglobin A1C (HbA1c) values covering total diabetes duration could predict retinopathy in younger-onset type 1 diabetes mellitus (T1DM).

RESEARCH DESIGN AND METHODS
Inclusion criteria were T1DM onset before age 30 years, first visit to our center between 1988 and 1990 soon after onset, continuous HbA1c data for 20 years, and a 20-year follow-up retinopathy examination. Retinopathy predictive capabilities of HbA1c variables were examined.

RESULTS
Of 15 subjects, 5 were retinopathy-positive and 10 were retinopathy-negative at the 20-year follow-up. Mean metabolic memory-free HbA1c values for the 20 years showed a substantial capacity to predict retinopathy at 20 years. The longer the period without HbA1c data following onset in simulation, the less accurate the prediction.

CONCLUSIONS
HbA1c values may predict retinopathy better if metabolic memory-free data are used.
B-Lymphocyte Depletion With Rituximab and β-Cell Function: Two-Year Results
Authors: Pescovitz Mark D. , Greenbaum Carla J. , Bundy Brian , Becker Dorothy J. , Gitelman Stephen E. , Goland Robin , Gottlieb Peter A. , Marks Jennifer B. , Moran Antoinette , Raskin Philip , Rodriguez Henry , Schatz Desmond A. , Wherrett Diane K. , Wilson Darrell M. , Krischer Jeffrey P. , Skyler Jay S. ,   the Type 1 Diabetes TrialNet Anti-CD20 Study Group
Published: September 2013

OBJECTIVE
We previously reported that selective depletion of B-lymphocytes with rituximab, an anti-CD20 monoclonal antibody, slowed decline of β-cell function in recent-onset type 1 diabetes mellitus (T1DM) at 1 year. Subjects were followed further to determine whether there was persistence of effect.

RESEARCH DESIGN AND METHODS
Eighty-seven subjects (aged 8–40 years) were randomly assigned to, and 81 received, infusions of rituximab or placebo on days 1, 8, 15, and 22. The primary outcome—baseline-adjusted mean 2-h area under the curve (AUC) serum C-peptide during a mixed-meal tolerance test (MMTT) at 1 year—showed higher C-peptide AUC with rituximab versus placebo. Subjects were further followed with additional MMTTs every 6 months.

RESULTS
The rate of decline of C-peptide was parallel between groups but shifted by 8.2 months in rituximab-treated subjects. Over 30 months, AUC, insulin dose, and HbA1c were similar for rituximab and placebo. However, in evaluating change in C-peptide over the entire follow-up period, the rituximab group means were significantly larger as compared within assessment times with the placebo group means using a global test (P = 0.03). Odds ratio for loss of C-peptide to &lt;0.2 nmol/L following rituximab was 0.565 (P = 0.064). B-lymphocytes recovered to baseline values by 18 months. Serum IgG levels were maintained in the normal range but IgM levels were depressed.

CONCLUSIONS
Like several other immunotherapeutic approaches tested, in recent-onset T1DM, rituximab delays the fall in C-peptide but does not appear to fundamentally alter the underlying pathophysiology of the disease.
Feasibility of Closed-Loop Insulin Delivery in Type 2 Diabetes: A Randomized Controlled Study
Authors: Kumareswaran Kavita , Thabit Hood , Leelarathna Lalantha , Caldwell Karen , Elleri Daniela , Allen Janet M. , Nodale Marianna , Wilinska Malgorzata E. , Evans Mark L. , Hovorka Roman 
Published: September 2013

OBJECTIVE
Closed-loop insulin delivery offers a promising treatment option, but to date, it has only been evaluated in type 1 diabetes. Our aim was to evaluate the feasibility of fully closed-loop subcutaneous insulin delivery in insulin-naïve patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
Twelve subjects (seven males, age 57.2 years, BMI 30.5 kg/m2) with noninsulin-treated type 2 diabetes (HbA1c 8.4% [68 mmol/mol], diabetes duration 7.6 years) underwent two 24-h visits (closed-loop and control) in a randomized crossover design. During closed-loop visits, the subjects’ routine diabetes therapy was replaced with model predictive control algorithm-driven subcutaneous insulin pump delivery based on real-time continuous glucose monitoring. Meals were unannounced, and no additional insulin was administered for carbohydrates consumed. During control visits, the usual diabetes regimen was continued (metformin 92%, sulfonylureas 58%, dipeptidyl peptidase-4 inhibitors 33%). On both visits, subjects consumed matched 50- to 80-g carbohydrate meals and optional 15-g carbohydrate snacks and remained largely sedentary. Plasma glucose measurements evaluated closed-loop performance.

RESULTS
Compared with conventional therapy, 24 h of closed-loop insulin delivery increased overall the median time in target plasma glucose (3.9–8.0 mmol/L) from 24 to 40% (P = 0.016), despite sensor under-reading by a median of 1.2 mmol/L. The benefit of the closed-loop system was more prominent overnight, with greater time in target glucose (median 78 vs. 35%; P = 0.041) and less time in hyperglycemia (22 vs. 65%; P = 0.041). There was no hypoglycemia during either intervention.

CONCLUSIONS
A closed-loop system without meal announcement and using subcutaneous insulin delivery in insulin-naïve patients with type 2 diabetes appears feasible and safe. Improvement in postprandial glucose control may require further optimization of system performance.
Correlates of Treatment Patterns Among Youth With Type 2 Diabetes
Authors: Badaru Angela , Klingensmith Georgeanna J. , Dabelea Dana , Mayer-Davis Elizabeth J. , Dolan Lawrence , Lawrence Jean M. , Marcovina Santica , Beavers Daniel , Rodriguez Beatriz L. , Imperatore Giuseppina , Pihoker Catherine 
Published: September 2013

OBJECTIVE
To describe treatment regimens in youth with type 2 diabetes and examine associations between regimens, demographic and clinical characteristics, and glycemic control.

RESEARCH DESIGN AND METHODS
This report includes 474 youth with a clinical diagnosis of type 2 diabetes who completed a SEARCH for Diabetes in Youth study visit. Diabetes treatment regimen was categorized as lifestyle alone, metformin monotherapy, any oral hypoglycemic agent (OHA) other than metformin or two or more OHAs, insulin monotherapy, and insulin plus any OHA(s). Association of treatment with demographic and clinical characteristics (fasting C-peptide [FCP], diabetes duration, and self-monitoring of blood glucose [SMBG]), and A1C was assessed by χ2 and ANOVA. Multiple linear regression models were used to evaluate independent associations of treatment regimens and A1C, adjusting for demographics, diabetes duration, FCP, and SMBG.

RESULTS
Over 50% of participants reported treatment with metformin alone or lifestyle. Of the autoantibody-negative youth, 40% were on metformin alone, while 33% were on insulin-containing regimens. Participants on metformin alone had a lower A1C (7.0 ± 2.0%, 53 ± 22 mmol/mol) than those on insulin alone (9.2 ± 2.7%, 77 ± 30 mmol/mol) or insulin plus OHA (8.6 ± 2.6%, 70 ± 28 mmol/mol) (P &lt; 0.001). These differences remained significant after adjustment (7.5 ± 0.3%, 58 ± 3 mmol/mol; 9.1 ± 0.4%, 76 ± 4 mmol/mol; and 8.6 ± 0.4%, 70 ± 4 mmol/mol) (P &lt; 0.001) and were more striking in those with diabetes for ≥2 years (7.9 ± 2.8, 9.9 ± 2.8, and 9.8 ± 2.6%). Over one-half of those on insulin-containing therapies still experience treatment failure (A1C ≥8%, 64 mmol/mol).

CONCLUSIONS
Approximately half of youth with type 2 diabetes were managed with lifestyle or metformin alone and had better glycemic control than individuals using other therapies. Those with longer diabetes duration in particular commonly experienced treatment failures, and more effective management strategies are needed.
Protective effect of tea polyphenols on the blood-brain barrier
Authors: Xue Rongliang , Lv Jianrui , Gao Jing , Fu Rongguo , Li Wei , Lei Xiaoming , Wu Gang , Xue Li , Zhang Zhenni 
Published: September 2013

AbstractThis study was to investigate the protective effects of tea polyphenols on the blood-brain barrier (BBB) of rats with global cerebral ischemia/reperfusion (GCIR) injury. Sprague Dawley rats underwent four-vessel occlusion to construct the model of GCIR. Half an hour before complete occlusion, they were treated with tea polyphenols (TP) (6.4%; 100 or 200 mg/kg) via tail intravenous injection. 24 h after reperfusion, BBB permeability was evaluated by measuring brain water content (BWC) and residual amount of Evan’s blue dye in cerebral tissue. In addition to this, MMP-9 and collagen IV protein expression in cerebral tissue were also detected using immunohistochemistry. ANOVA and SNK-q were used to do statistical analysis. Statistical significance was considered at P<0.05. Compared to the untreated, the TP-treated rats had significantly decreased BWC (P<0.05), decreased residual amount of Evan’s blue dye in cerebral tissue (P<0.05), down-regulated MMP-9 (P<0.05) and up-regulated collagen IV expression in brain tissue (P<0.05). It can be concluded from these findings that TP may reduce the MMP-9 mediated collagen IV degradation caused by GCIR to protect the BBB.
Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors
Authors: Štefulj Jasminka , Panzenboeck Ute , Hof Patrick , Šimić Goran 
Published: September 2013

AbstractThe pathogenesis of Alzheimer’s disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.
Assessing the Temporal Variation in the Perceived Eects of Invasive Plant Species on Rural Livelihoods: A Case of Mikania micrantha Invasion in Nepal
Authors: Rai Rajesh Kumar , Rai Roshani 
Published: September 2013

Aim This study aims to assess effects of invasion of Mikania micrantha on the livelihoods of rural communities and evaluates how perceived effects vary with the presence duration of invasive plants in a particular landscape. Location The study was conducted in the buffer zone communities of two protected areas in Nepal—Koshi Tappu Wildlife Reserve and Chitwan National Park. Materials and Methods Questionnaire interviews were performed among a total of 473 households from the target communities. The questionnaire mainly focused on a five-year gap evaluation of the current situation. The households were stratified into three strata based on their proximity to the forest and a systematic random sampling was used to select the households. Household heads of either gender were interviewed based on their availability during the visit. Key findings The results show that time decay effects exist in the interface between invasive plants and rural livelihoods, as people gradually start to consider that these plants have self-grown in their landscape. However, the number of affected households increases with duration of the stay of invasive plants in the landscape. Conservation implications The study shows that the perceived effects of invasive plants on rural households vary over time, and hence the response of rural households to the invasion. On the contrary, the perceived ecological effects of invasive plants remain the same. The results indicate the complication in managing the invaded area particularly in rural areas, which has forced the local people to use invasive plants such as Mikania in their daily lives in the absence of any strategy to control its spread. However, it can be concluded that Mikania cannot win the support of local communities in the invaded areas. DOI: http://dx.doi.org/10.3126/cs.v1i1.8579 Conservation Science 2013 1(1), 13-18