bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wideband dipole antenna using multiple‐mode resonator for long‐term evolution application
Authors: Zheng Yu‐Fa , Wong Sai‐Wai , Huang Qi‐Kai , Wang Kai , Zhu Lei , Chu Qing‐Xin 
Published: November 2015

A coplanar waveguide fed wideband dipole antenna using a multiple‐mode resonator is proposed and developed. A simple dipole antenna structure is investigated for its wideband radiation performance by virtue of its single, double, triple and quadruplet resonant modes. Later, a metallic reflector is properly installed in order to provide a unidirectional radiation pattern as demanded for the long‐term evolution (LTE) application. In the design, a quadruplet‐mode wideband dipole antenna is explored to cover the LTE operation band with a 10 dB fractional bandwidth of 46.8%. Finally, an antenna prototype is fabricated and tested to experimentally verify the expected wideband property and predicted results.
Power plant control in large‐scale photovoltaic plants: design, implementation and validation in a 9.4 MW photovoltaic plant
Authors: Bullich‐Massagué Eduard , Ferrer‐San‐José Ricard , Aragüés‐Peñalba Mònica , Serrano‐Salamanca Luis , Pacheco‐Navas Carlos , Gomis‐Bellmunt Oriol 
Published: November 2015

This study proposes an algorithm for active and reactive power management in large photovoltaic (PV) power plants. The algorithm is designed in order to fulfil the requirements of the most demanding grid codes and combines the utilisation of the PV inverters, fixed switched capacitors and static synchronous compensators. The control algorithm is simulated as required by the grid codes and validated on a real 9.4 MW PV power plant.
Shifts in coral reef biogeochemistry and resulting acidification linked to offshore productivity
Authors: Yeakel Kiley L. , Andersson Andreas J. , Bates Nicholas R. , Noyes Timothy J. , Collins Andrew , Garley Rebecca 
Published: November 2015

Significance
Ocean acidification is hypothesized to have a negative impact on coral reef ecosystems, but to understand future potential impacts it is necessary to understand the natural variability and controls of coral reef biogeochemistry. Here we present a 5-y study from the Bermuda coral reef platform that demonstrates how rapid interannual acidification events on the local reef scale are driven by shifts in reef biogeochemical processes toward increasing net calcification and net respiration. These biogeochemical shifts are possibly linked to offshore productivity that ultimately may be controlled by large-scale climatological and oceanographic processes.
HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart
Authors: Lam Chi Keung , Zhao Wen , Liu Guan-Sheng , Cai Wen-Feng , Gardner George , Adly George , Kranias Evangelia G. 
Published: November 2015

SignificanceThe massive cell death, associated with a heart attack, is mainly due to disruption of mitochondrial membrane integrity upon activation of the mitochondrial permeability transition pore. Thus, it is important to understand how this pore is regulated to prevent cardiac cell death. In this study, we reported that hematopoietic-substrate-1 associated protein X-1 (HAX-1) is an inhibitor of the pore and promotes cell survival. HAX-1 works through recruitment of a chaperone protein called Hsp90 from cyclophilin-D, a major component of the pore. Displacement of Hsp90 from cyclophilin-D promotes cyclophilin-D degradation, resulting in inhibition of pore opening and cell death. Given that the opening of the mitochondrial permeability transition pore contributes to various diseases, our findings have broader applications reaching beyond the heart.
Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck
Authors: Banjade Sudeep , Wu Qiong , Mittal Anuradha , Peeples William B. , Pappu Rohit V. , Rosen Michael K. 
Published: November 2015

Significance
Many eukaryotic proteins are composed of tandem arrays of modular domains, which bind peptide ligands that also often appear in tandem arrays. The interdomain linkers in such systems are often considered merely passive elements that flexibly connect the functional domains. Collective interactions among multivalent molecules lead to micron-sized phase-separated states that are thought to be important in cellular organization. Here, we show that in the multivalent signaling adaptor protein Nck, weak interactions involving an interdomain linker play a significant role in self-assembly and phase separation with ligands neuronal Wiskott-Aldrich syndrome protein (N-WASP) and phosphorylated nephrin. Our results suggest that interactions mediated by ordered modular domains may generally act synergistically with weak interactions of disordered interdomain linkers to promote phase separation.
Choosing experiments to accelerate collective discovery
Authors: Rzhetsky Andrey , Foster Jacob G. , Foster Ian T. , Evans James A. 
Published: November 2015

Significance
Scientists perform a tiny subset of all possible experiments. What characterizes the experiments they choose? And what are the consequences of those choices for the pace of scientific discovery? We model scientific knowledge as a network and science as a sequence of experiments designed to gradually uncover it. By analyzing millions of biomedical articles published over 30 y, we find that biomedical scientists pursue conservative research strategies exploring the local neighborhood of central, important molecules. Although such strategies probably serve scientific careers, we show that they slow scientific advance, especially in mature fields, where more risk and less redundant experimentation would accelerate discovery of the network. We also consider institutional arrangements that could help science pursue these more efficient strategies.
Allosteric N-WASP activation by an inter-SH3 domain linker in Nck
Authors: Okrut Julia , Prakash Sumit , Wu Qiong , Kelly Mark J. S. , Taunton Jack 
Published: November 2015

Significance
Actin is a monomeric protein that can polymerize into branched networks. Actin polymerization acts like an engine to drive cell movement and is regulated by multiple interacting proteins on the cell membrane. To understand the molecular details of how cells transmit signals from the membrane to the actin polymerization engine, we reconstituted this process in a test tube using seven purified proteins and membrane-coated glass beads. Using this “biomimetic” system, we discovered a sequence motif in the human protein Nck that activates a core component of the actin polymerization engine. This motif shares similarity with certain bacterial virulence factors that stimulate actin polymerization in infected human cells, suggesting that similar activation mechanisms have evolved in humans and bacterial pathogens.
Self-assembly of smallest magnetic particles
Authors: Mehdizadeh Taheri Sara , Michaelis Maria , Friedrich Thomas , Förster Beate , Drechsler Markus , Römer Florian M. , Bösecke Peter , Narayanan Theyencheri , Weber Birgit , Rehberg Ingo , Rosenfeldt Sabine , Förster Stephan 
Published: November 2015

Significance
We discovered that small magnetic nanocubes spontaneously assemble into highly ordered chains, sheets, and cuboids in solution by applying a magnetic field. We elucidate how these assemblies are formed by working out the three-dimensional equilibrium arrangement of the dipoles. This classic physics problem turned out to be amazingly complex. The discovered solution self-assembly process is of high relevance in various fields reaching from high-density data storage over magnetotactic cells to medical applications.
Optimal directional volatile transport in retronasal olfaction
Authors: Ni Rui , Michalski Mark H. , Brown Elliott , Doan Ngoc , Zinter Joseph , Ouellette Nicholas T. , Shepherd Gordon M. 
Published: November 2015

Significance
We have analyzed adaptations of the human airway to enhance transport of food volatiles underlying retronasal smell during expiration as well as limit transport in the opposite orthonasal direction toward the lung during inspiration. We show experimentally using an anatomically based flow dynamic model that the structure of the human airway at the back of the mouth enhances the entrainment of volatiles during expiration and minimizes it during inspiration. Unexpectedly, this effect is largest in a small range of flow rates, which coincides with quiet breathing. Our findings provide insight into the retronasal olfaction process and the adaptation of the shape of the human airway.
Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection
Authors: Au Hilda H. , Cornilescu Gabriel , Mouzakis Kathryn D. , Ren Qian , Burke Jordan E. , Lee Seonghoon , Butcher Samuel E. , Jan Eric 
Published: November 2015

Significance
Viruses use alternate mechanisms to increase the coding capacity of their viral genomes. The dicistrovirus intergenic region internal ribosome entry site (IRES) adopts an RNA structure that can direct translation in 0 and +1 reading frames to produce the viral structural proteins and an overlapping ORFx product. Here we provide structural and biochemical evidence that the PKI domain of the IRES mimics a complete tRNA-like structure to facilitate reading frame selection and allows the viral IRES to engage the ribosome. These findings provide insight into how a viral IRES can increase the coding capacity of a viral genome.
Dynamic response of desert wetlands to abrupt climate change
Authors: Springer Kathleen B. , Manker Craig R. , Pigati Jeffrey S. 
Published: November 2015

SignificanceA paleohydrologic record from the Las Vegas Valley (southern Nevada, United States) shows that desert wetlands were extremely sensitive to rapid climatic changes during the past 35,000 years and exhibit temporal congruence with the Greenland ice core record. Wetlands in the valley expanded and contracted many times in response to climatic events during this period, including Dansgaard–Oeschger cycles and other millennial and submillennial climatic perturbations. Widespread erosion occurred when entire wetland systems collapsed during exceptionally dry times. Drought-like conditions typically lasted for a few centuries, which highlights the threat of anthropogenic warming to endemic fauna and flora that depend on desert wetlands to provide a consistent source of water in an otherwise arid landscape.
Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver
Authors: Atger Florian , Gobet Cédric , Marquis Julien , Martin Eva , Wang Jingkui , Weger Benjamin , Lefebvre Grégory , Descombes Patrick , Naef Felix , Gachon Frédéric 
Published: November 2015

Significance
Rhythmic gene regulation in mouse liver results from an intertwined relationship between feeding cycles and the circadian clock. Significant efforts have been made to understand this interaction but a complete picture of the resulting diurnal transcription–translation processes is still missing. Through the simultaneous quantification of temporal transcription, accumulation, and translation of mRNA in the liver, we investigated the regulatory landscape of mice with intact or deficient circadian clock subjected to different feeding regimens. We showed that circadian clock and feeding rhythms coordinate rhythmic transcription to drive downstream rhythmic mRNA accumulation and translation. However, a subset of genes harboring 5′-Terminal Oligo Pyrimidine tract or Translation Initiator of Short 5′-UTR elements encoding proteins involved in translation and mitochondrial activity, respectively, present a transcription-independent rhythmic translation mainly regulated by feeding.
Accurate estimation of influenza epidemics using Google search data via ARGO
Authors: Yang Shihao , Santillana Mauricio , Kou S. C. 
Published: November 2015

SignificanceBig data generated from the Internet have great potential in tracking and predicting massive social activities. In this article, we focus on tracking influenza epidemics. We propose a model that utilizes publicly available Google search data to estimate current influenza-like illness activity level. Our model outperforms all available Google-search–based real-time tracking models for influenza epidemics at the national level of the United States, including Google Flu Trends. Our model is flexible, self-correcting, robust, and scalable, making it a potentially powerful tool that can be used for estimation and prediction at multiple temporal and spatial resolutions for other social events.
Ultraflexible, large-area, physiological temperature sensors for multipoint measurements
Authors: Yokota Tomoyuki , Inoue Yusuke , Terakawa Yuki , Reeder Jonathan , Kaltenbrunner Martin , Ware Taylor , Yang Kejia , Mabuchi Kunihiko , Murakawa Tomohiro , Sekino Masaki , Voit Walter , Sekitani Tsuyoshi , Someya Takao 
Published: November 2015

Significance
We have successfully fabricated very unique ultraflexible temperature sensors that exhibit changes in resistivity by six orders of magnitude or more for a change in temperature of only 5 °C or less. Our approach offers an ideal solution to measure temperature over a large area with high spatial resolution, high sensitivity of 0.1 °C or less, and fast response time of 100 ms. Indeed, such a large change of resistivity for our sensors can significantly simplify the readout circuitry, which was the key to demonstrate, to our knowledge, the world’s first successful measurement of dynamic change of temperature in the lung during very fast artificial respiration. Furthermore, we have demonstrated real-time multipoint thermal sensing using organic transistor active-matrix circuits.
Using prediction markets to estimate the reproducibility of scientific research
Authors: Dreber Anna , Pfeiffer Thomas , Almenberg Johan , Isaksson Siri , Wilson Brad , Chen Yiling , Nosek Brian A. , Johannesson Magnus 
Published: November 2015

Significance
There is increasing concern about the reproducibility of scientific research. For example, the costs associated with irreproducible preclinical research alone have recently been estimated at US$28 billion a year in the United States. However, there are currently no mechanisms in place to quickly identify findings that are unlikely to replicate. We show that prediction markets are well suited to bridge this gap. Prediction markets set up to estimate the reproducibility of 44 studies published in prominent psychology journals and replicated in The Reproducibility Project: Psychology predict the outcomes of the replications well and outperform a survey of individual forecasts.
Dynamic allostery governs cyclophilin A–HIV capsid interplay
Authors: Lu Manman , Hou Guangjin , Zhang Huilan , Suiter Christopher L. , Ahn Jinwoo , Byeon In-Ja L. , Perilla Juan R. , Langmead Christopher J. , Hung Ivan , Gor'kov Peter L. , Gan Zhehong , Brey William , Aiken Christopher , Zhang Peijun , Schulten Klaus , Gronenborn Angela M. , Polenova Tatyana 
Published: November 2015

Significance
The mechanisms of how Cyclophilin A (CypA) regulates HIV-1 infectivity remain poorly understood. We examined the role of dynamics in capsid (CA) protein assemblies by magic-angle-spinning NMR. The assembled CA is highly dynamic. Dipolar tensors calculated from molecular dynamics trajectories are in quantitative agreement with the NMR results. Motions in the CypA loop are sequence-dependent and attenuated in the escape mutants A92E and G94D. Dynamics are similar in escape mutants and CA/CypA complex. These findings suggest that CA escapes from CypA dependence through dynamic allostery. Thus, a host factor's function in HIV infectivity may not be primarily associated with a structural change of the capsid core, but with altering its dynamics, such as the reduction of motions for the CypA loop.
Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives
Authors: Li Xin-min , Zheng Ke-wei , Zhang Jia-yu , Liu Hong-he , He Yi-de , Yuan Bi-feng , Hao Yu-hua , Tan Zheng 
Published: November 2015

Significance
Guanine-rich nucleic acids fold into a four-stranded structure named G-quadruplex that has implications in essential cellular processes, pharmaceutical applications, and nanodevices. We found a unique type of G-quadruplex that contains a G-vacancy and is stabilized by guanine derivatives such as te physiological concentration of GTP by fill-in at the G-vacancy of a guanine base. In response to changes in the concentration of guanine derivatives, this type of G-quadruplex is able to manipulate the tracking activity of protein on DNA as exemplified by a DNA polymerase-catalyzed DNA synthesis. Because guanine derivatives are natural metabolites in cells, such G-quadruplexes may potentially play an environment-responsive regulation in cellular processes, a functional property not found in the canonical G-quadruplexes.
Retrading, production, and asset market performance
Authors: Gjerstad Steven D. , Porter David , Smith Vernon L. , Winn Abel 
Published: November 2015

Significance
We conduct the first experimental study to our knowledge of production and trade in a stock-flow market for durable assets. When inexperienced consumers are allowed to resell assets they compete with producers and depress prices, disrupting production and causing inefficiency. Consumers with experience specializing as buyers compete less vigorously, which allows prices and production to converge to equilibrium.
Heterogeneous lamella structure unites ultrafine-grain strength with coarse-grain ductility
Authors: Wu Xiaolei , Yang Muxin , Yuan Fuping , Wu Guilin , Wei Yujie , Huang Xiaoxu , Zhu Yuntian 
Published: November 2015

Significance
For centuries it has been a challenge to avoid strength–ductility trade-off, which is especially problematic for ultrastrong ultrafine-grained metals. Here we evade this trade-off dilemma by architecting a heterogeneous lamella structure, i.e., soft micrograined lamellae embedded in hard ultrafine-grained lamella matrix. The heterogeneous deformation of this previously unidentified structure produces significant back-stress hardening in addition to conventional dislocation hardening, rendering it higher strain hardening than coarse-grained metals. The high back-stress hardening makes the material as strong as ultrafine-grained metals and as ductile as coarse-grained metals.
Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V
Authors: Trivedi Darshan V. , Muretta Joseph M. , Swenson Anja M. , Davis Jonathon P. , Thomas David D. , Yengo Christopher M. 
Published: November 2015

Significance
Myosins interact with actin filaments and convert the chemical energy from ATP hydrolysis into mechanical work. The swinging lever arm hypothesis describes the molecular mechanism of actomyosin-based force generation that is essential for cell motility, muscle contraction, and cell division. In this model the light chain-binding region of myosin undergoes a major conformational change, which drives force generation. However, the temporal kinetics of structural changes in the lever arm in relation to the product release steps of the catalytic cycle are not well established. By using a FRET-based strategy, we demonstrate the lever arm swing occurs in two steps, a rapid step prior to phosphate release and a slower step prior to ADP release.
Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA
Authors: Yin Ai-hua , Peng Chun-fang , Zhao Xin , Caughey Bennett A. , Yang Jie-xia , Liu Jian , Huang Wei-wei , Liu Chang , Luo Dong-hong , Liu Hai-liang , Chen Yang-yi , Wu Jing , Hou Rui , Zhang Mindy , Ai Michael , Zheng Lianghong , Xue Rachel Q. , Mai Ming-qin , Guo Fang-fang , Qi Yi-ming , Wang Dong-mei , Krawczyk Michal , Zhang Daniel , Wang Yu-nan , Huang Quan-fei , Karin Michael , Zhang Kang 
Published: November 2015

Significance
Noninvasive prenatal testing (NIPT) using sequencing of fetal cell-free DNA from maternal plasma has allowed accurate prenatal diagnosis of aneuploidy without requirement of an invasive procedure; this approach has gained increasing clinical acceptance. In this manuscript, we evaluate whether NIPT using semiconductor sequencing platform (SSP) could reliably detect subchromosomal deletions/duplications in women carrying a high-risk fetus. We show that detection of fetal subchromosomal abnormalities is a viable extension of NIPT using SSP. Given the recent strong interest in NIPT using cell-free DNA, these results should be of broad interest and immediate clinical importance, even beyond the NIPT field, such as for detection of cell-free tumor DNA.
Mapping transient electric fields with picosecond electron bunches
Authors: Chen Long , Li Runze , Chen Jie , Zhu Pengfei , Liu Feng , Cao Jianming , Sheng Zhengming , Zhang Jie 
Published: November 2015

Significance
Transient electric fields driven by intense lasers and particle beams play a key role in a number of applications from plasma-based particle accelerators to implosion dynamics of inertial fusion targets. Here, a method to map the 3D transient field structures with high resolutions both in time and space by use of picosecond electron bunches is presented. It is applied to measure the transient field evolution induced at a solid surface irradiated by a short pulse laser. This method can be applied to monitor field structures with much higher strength, which may find wide application in relevant research fields.
Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope
Authors: Tsai Shang-Yi A. , Chuang Jian-Ying , Tsai Meng-Shan , Wang Xiao-fei , Xi Zheng-Xiong , Hung Jan-Jong , Chang Wen-Chang , Bonci Antonello , Su Tsung-Ping 
Published: November 2015

Significance
The endoplasmic reticulum (ER), although functioning as protein synthesis machinery in the cell, plays other important roles that have yet to be fully unveiled. We found here that the ER can directly send an envoy protein, the sigma-1 receptor (Sig-1R), to the nuclear envelope (NE), where the Sig-1R begins to recruit chromatin-remodeling molecules through the NE integral protein emerin to control gene transcription. Thus, the Sig-1R represents a molecule that shapes the functional connection between the NE and the DNA. We also demonstrate in this study that cocaine, a Sig-1R agonist, down-regulates the critical enzyme monoamine oxidase B that influences the cocaine-induced dopamine level in a dopamine transporter-independent manner via this never-before-described, to our knowledge, Sig-1R-linked genomic action of cocaine.
Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow
Authors: Dore Kim , Aow Jonathan , Malinow Roberto 
Published: November 2015

Significance
NMDA receptors (R) are ion channels that participate in many important physiological and pathophysiological processes in the brain. Recent studies suggest that NMDARs can also act in a manner that does not require ion flow. One way this could occur is for agonist binding to the NMDAR to produce conformational movement of its cytoplasmic domain in the absence of ion flow. Here we use FRET imaging of genetically encoded fluorescent proteins linked to the cytoplasmic domain of NMDAR subunits to monitor directly agonist-driven movement within the cytoplasmic domain of NMDARs. This study demonstrates that transmembrane information transfer through the NMDAR is possible in the absence of ion flow through the receptor.