bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percepção dos Discentes sobre o Uso de Práticas Pedagógicas Proativas no Ensino Híbrido de Anatomia
Authors: Freitas Emília , Spiegel Carolina , Tavares Kátia 
Published: July 2024

As tecnologias digitais de informação e comunicação têm sido gradualmente incorporadas ao ensino de Anatomia, com estudos destacando experiências de sua integração ao ensino tradicional. Contudo, tais práticas ainda ocorrem de maneira pontual, não sendo contínuas na disciplina. Este artigo visa analisar a percepção de Licenciandos em Educação Física de uma Universidade Pública do Rio de Janeiro sobre práticas pedagógicas inovadoras em Anatomia, que adotam o ensino híbrido e metodologias ativas. A pesquisa-ação prática foi conduzida pela professora em sua sala de aula, com dados gerados por meio de diário de pesquisa, notas de campo e questionário. Para tabular os dados quantitativos e produzir os gráficos utilizou-se o Microsoft Excel. Os resultados foram analisados em conjunto com os dados qualitativos provenientes das questões abertas do questionário. Os resultados obtidos foram favoráveis à inovação pedagógica implementada, uma vez que os estudantes se perceberam como protagonistas nas práticas pedagógicas e relataram que aprenderam de forma motivadora, dinâmica, lúdica e divertida os conteúdos da disciplina de Anatomia. A integração consistente dessas práticas pode, assim, promover uma transformação mais ampla e duradoura no ensino de Anatomia.

Palavras-chave: Ensino híbrido. Metodologias ativas. Educação física. Educação superior.
CITRA BAHASA INDONESIA PADA PENAMAAN FASILITAS PARIWISATA LOMBOK BARAT
Authors: Suganam Agusman 
Published: July 2024

Penggunaan bahasa Indonesia harus ditempatkan pada urutan pertama sehingga bahasa asing diposisikan setelah bahasa Indonesia/daerah. Namun demikian, fakta di lapangan cukupberbeda dari apa yang diharapkan dan dijabarkan dalam peraturan tersebut. Faktanya ialah nama-nama fasiliatas pariwisata di kawasan Lombok Barat dan sekitarnya didominasi oleh penggunaan bahasa asing. Hal tersebut lantas membuat citra bahasa Indonesia hilang dan loyalitas terhadap bahasa Indonesia pun semakin menurun. Tujuan penelitian inipenelitian ialah mendeskripsikan citra bahasa Indonesia pada nama-nama fasiliatas pariwisata di kawasan Lombok Barat. Metode penelitian yang digunakan ialah kualitatif deskriptif. Eknik pengumpulan data yang digunakan ialah teknik catat dengan data penelitian berupa kata-kata yang memuat nama hotel, vila, kafe, dan restoran yang diperoleh dari fasilitas pariwisata. Teknik analisis data yang digunakan ialah deskriptif dengan membandingkan, menjelaskan dan menafsirkan data serta penarikan simpulan. Hasil penelitian menunjukkan bahwa nama fasilitas pariwisata di kawasan Lombok Barat didminasi oleh bahasa asing baik pada hotel, vila, kafe maupun restoran. Terdapat pola penamaan berupa menggunakan bahasa asing keseluruhan, menggunakan bahasa Indonesia/daerah dan campuran. Citra bahasa Indonesia pada nama-nama fasilitas pariwisata sangat tidak baik karena dinilai tidak memiliki gaya dan daya tarik sehingga dikalahkan oleh bahasa asing. Buruknya citra bahasa Indonesia merupakan implikasi dari rendahnya sikap bahasa masyarakat terhadap bahasa nasional.
MAKNA KONTEKSTUAL LEKSIKON DALAM RUBRIK POLITIK BLOG MOJOK.CO EDISI FEBRUARI 2022
Authors: Widyani Lisa , Rijadi Arief , Widjajanti Anita 
Published: July 2024

Semantik adalah cabang ilmu linguistik yang mempelajari tentang arti atau makna berupa perubahan dan perkembangan. Makna memiliki tiga aspek yakni meliputi makna leksikal, makna gramatikal, dan makna kontekstual. Makna kontekstual sederhananya yakni makna yang bergantung pada situasi kata atau ujaran tersebut digunakan. Permasalahan yang dikaji pada penelitian ini adalah Bentuk makna kontekstual leksikon dalam rubrik Politik pada blog Mojok.co edisi Februari 2022 dan Bentuk perubahan makna kontekstual leksikon dalam rubrik Politik pada blog Mojok.co edisi Februari 2022. Rancangan penelitian yang digunakan yakni naturalistic langkah-langkah umum. Pendekatan yang digunakan pada penelitian ini adalah Kualitatif., sedangkan Jenis penelitian yang digunakan adalah penelitian deskriptif. Hasil penelitian menunjukkan bahwa pada rubrik Politik Blog Mojok.co Edisi Februari 2022 terdapat lima bentuk satuan leksikon yang ditemukan yakni yaitu (1) Perbedaan bidang pemakaian (2) adanya asosiasi, (3) tanggapan indera (sinestesia), (4) perbedaan tanggapan, (5) pengembangan istilah. Bentuk perubahan makna kontekstual yang ditemukan dalam rubrik Politik Blog Mojok.co Edisi Februari 2022 yakni (1) Ditemukannya data perbedaan bidang pemakaian leksikon yang penggunaannya berbeda dengan makna sebenarnya (2) Adanya bentuk pengembangan istilah baik itu berupa meluas, dan pengasaran.
Fenomena Hijab dalam Perspektif Edmund Husserl pada Novel Kerudung di Titik Api Karya Moch. Taufik Hidayatullah dan Pemanfaatannya sebagai Alternatif Materi Pembelajaran Sastra di SMA
Authors: Ma’rifatin Ma’rifatin , Husniah Furoidatul , Siswanto Siswanto , Taufiq Akhmad , Edi Pornomo Bambang 
Published: July 2024

Kerudung adalah pakaian untuk perempuan muslimah yang menutupi bagian rambut, utamanya kepala. Bentuk kerudung yang variatif memiliki peran dan tampilan yang berbeda bagi para pemakaianya oleh karena itu, fenomena hijab khususnya kerudung dan bagaimana kerudung mempengaruhi tindak kesadaran penggunanya menjadi pembahasan dalam penelitian ini. Penelitian ini mengkaji fenomena hijab melalui salah satu karya sastra novel yang berjudul Kerudung Di Titik Api karya Moch. Taufik Hidayatullah. Tujuan pada penelitian ini adalah untuk mendiskripsikan bentuk dan peran kerudung serta kesadaran individual tokoh terhadap kerudung. dalam novel. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan sosiologi sastra yang menggunakan teori fenomenologi Edmund Husserl. Hasil pembahasan dalam penelitian ini dapat direlevansikan pada materi pembalajaran sastra di jenjang pendidikan SMA. Hasil pembahasan dalam penelitian ini yang pertama, bentuk kerudung yang berbeda memiliki peran yang berbeda pula terhadap kehidupan tokoh dalam novel. Kedua, kesadaran individual tokoh terhadap fenomena hijab memengaruhi ideologi dan relasi sosial tokoh dalam lingkungan hidupnya. Ketiga, hasil penelitian ini dapat direlevansikan sebagai alternatif materi pembelajaran bahasa Indonesia SMA kelas XII, tepatnya pada kompetensi dasar 3.9 (menganalisis isi dan kebahasaan novel).

A headscarf is clothing for Muslim women that covers the hair, especially the head. The varied forms of headscarves have different roles and appearances for those who wear them. Therefore, the phenomenon of the hijab, especially the headscarf, and how the headscarf influences the user's conscious actions are discussed in this research. This research examines the hijab phenomenon through a novel literary work entitled Veil at Point Api by Moch. Taufik Hidayatullah. The aim of this research is to describe the form and role of the veil as well as the individual characters' awareness of the veil. in the novel. The method used in this research is qualitative with a literary sociology approach using Edmund Husserl's phenomenological theory. The results of the discussion in this research can be relevant to literature learning material at the high school education level. The first result of the discussion in this research is that different forms of headscarves have different roles in the lives of the characters in the novel. Second, the character's individual awareness of the hijab phenomenon influences the character's ideology and social relations in their environment. Third, the results of this research can be relevant as an alternative Indonesian language learning material for class XII high school, specifically at basic competency 3.9 (analyzing the content and language of novels).
Mapping Evidence in Teaching Palliative Care in Undergraduate Curriculum of Healthcare Professionals Qualification: A Systematic Scoping Review Protocol
Authors: Nkambule Sphamandla Josias , Gaede  
Published: July 2024

Abstract

Background
Clinical Practice Guidelines recommend interprofessional collaboration in palliative care. However, healthcare profession educators lack clear curricular guidance, particularly for undergraduate programs, to adequately train future professionals for effective participation in such teams.
Objective
This systematic scoping review protocol aims to address this gap by: (i) mapping evidence on key characteristics of teaching palliative and end-of-life (EOL) care to undergraduate healthcare and social care students, and (ii) identifying the nature and effectiveness of educational interventions for improving palliative care education in the undergraduate curriculum.
Methods and Expected Outputs
The protocol adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol Extension for Scoping Reviews (PRISMA-P-ScR) guidelines, while the proposed systematic scoping review study will be conducted based on methods and steps identified by Arksey and O’Malley and experts in the field. We will conduct systematic searches across five EBSCOhost databases using relevant search terms. Additionally, a limited grey literature search will be conducted on the first 100 results of Google Scholar and Open-Grey. The selection process will follow PRISMA-Extension for Scoping Reviews. Two independent reviewers will screen titles and abstracts for eligibility. Data extraction will be done on standardized forms in duplicate with cross-checking by a third reviewer. Braun and Clarke's thematic analysis approach, combining thematic and directed content analysis, will be employed for analysis. Intervention effectiveness will be narratively summarized based on the TIDieR checklist. Meta-analysis will be considered if applicable and data is homogeneous.
Discussion
Palliative care education (PCE) is a crucial element of undergraduate health professions education. This study's findings may aid educators in fostering optimal learning among healthcare students, who can then positively influence community health outcomes.
Ethics and dissemination
The protocol was submitted for ethical clearance to the University of KwaZulu-Natal's Biomedical Research Ethics Committee and granted exemption from ethics review (00024289). We will disseminate findings through scientific journal publication and by sharing a summary with relevant institutions and attendees at health promotion and interprofessional education conferences.
Protocol registration number: CRD42023481892
https://www.crd.york.ac.uk/prospero/export_details_pdf.php
Generation of hypoimmunogenic universal iPSCs through HLA-type gene knockout
Authors: Ju Ji Hyeon , Kim Juryun , Nam Yoojun , Jeon Doyeong , Choi Yujin , Choi SeonJu , Hong Chang Pyo , Jung Hyerin , Park Narae , Sohn Yeowon , Rim Yeri Alice 
Published: July 2024

Abstract

Hypoimmunogenic universal induced pluripotent stem cells (iPSCs) were generated through the targeted disruption of key genes, including human leukocyte antigen (HLA)-A, HLA-B, and HLA-DR alpha (DRA), using the CRISPR/Cas9 system. This approach aimed to minimize immune recognition and enhance the potential of iPSCs for allogeneic therapy. Heterozygous iPSCs were used for guide RNA (gRNA) design and validation to facilitate the knockout (KO) of HLA-A, HLA-B, and HLA-DRA genes. Electroporation of iPSCs using the selected gRNAs enabled the generation of triple-KO iPSCs, followed by single-cell cloning for clone selection. Clone A7, an iPSC with a targeted KO of HLA-A, HLA-B, and HLA-DRA genes, was identified as the final candidate. mRNA analysis revealed robust expression of pluripotency markers, such as octamer-binding transcription factor 4 (OCT4), SRY (sex-determining region Y)-box 2 (SOX2), Krüppel-like factor 4 (KLF4), Lin-28 homolog A (LIN28), and Nanog homeobox (NANOG), while protein expression assays confirmed the presence of OCT4, stage-specific embryonic antigen 4 (SSEA4), NANOG, and tumor rejection antigen 1–60 (TRA-1-60). Karyotype examination demonstrated no anomalies, and three germ layer differentiation assays confirmed differentiation potential. Following interferon-gamma (INF-γ) stimulation, the gene-corrected clone A7 exhibited the absence of HLA-A, HLA-B, and HLA-DR protein expression. Immunogenicity testing further confirmed the hypoimmunogenicity of Clone A7, which was evidenced by the absence of proliferation in central memory T cells (TCM) and effector memory T cells (TEM). In conclusion, Clone A7, a triple KO iPSC clone that demonstrates immune evasion properties, retained its intrinsic iPSC characteristics and exhibited no immunogenicity.
Crosstalk between adult human retinas: exploring neurovascular coupling through photic stimulation for contralateral retina reflex insights.
Authors: Bernardes Rui , Jordão João , Figueira João , Morgado Miguel , Guimarães Pedro , Serranho Pedro , Farias Daniela Castro , DeBuc Delia Cabrera , Castelo-Branco Miguel , Paques Michel 
Published: July 2024

Abstract

Crosstalk mechanisms between retinas were never documented in humans despite being documented for several other species, including non-human primates. Here, we report the results of the first-in-human study that documents the crosstalk between retinas by measuring the vascular response in one retina to the photic stimulation of the contralateral eye in health and disease. We developed a stimulation apparatus and integrated it into an adaptive-optics fundus camera to image 22 healthy control (HC) subjects and 7 type 1 diabetes mellitus (DM) patients. We documented both the ipsilateral and the contralateral neurovascular coupling effect and established criteria to consider an actual response to find positive and negative responses. Eight (36.4%) and two (9.1%) subjects of the HC group presented contralateral positive and negative responses, respectively, and two (28.6%), one positive and one negative responses, were found for the DM group. Also, statistically significant differences in the ipsilateral and contralateral responses were found for the HC group, rejecting the null (non-response) hypothesis. This finding raises the need to revisit the current knowledge of neurovascular coupling mechanisms and the association between its dysregulation and neurological disorders. Further studies involving distinct populations and imaging centers are necessary to validate the findings herein.
Western U.S. snowfall loss derived from regional climate model large ensemble
Authors: Norris Jesse , Rahimi Stefan , Huang Lei , Bass Benjamin , Thackeray Chad , Hall Alex 
Published: July 2024

Abstract

The western United States is dependent on winter snowfall over its major mountain ranges, which gradually melts each year, serving as a natural reservoir for water resources. In a future warmer climate, much of this snowfall could be replaced by rain, making it more challenging to capture and store water. In this study, we utilize an ensemble of dynamically downscaled simulations forced by 12 global climate models (GCMs). These GCMs project wildly different futures, in terms of both temperature and precipitation change, producing significant uncertainty in snowfall projections. Here we exploit the robust statistics of the downscaled ensemble, and diagose the sensitivity of end-of-century snowfall loss across the region to both warming and regional wetting/drying in the driving GCM. The windward slopes of the Sierra Nevada and Cascades are particularly sensitive to warming (losing ∼15% annual snowfall per degree warming), with little influence of precipitation. By contrast, snowfall loss in the inter-mountain west is less sensitive to warming (∼5%/K), but is significantly offset/exacerbated by precipitation changes (∼0.5% snow per 1% precipitation). Combining such sensitivities with the warming and regional precipitation signals in the full CMIP6 ensemble, we can fully quantify likely snowfall loss and its uncertainty at any location, for any emissions scenario. We find that the western U.S. as a whole will lose 34±8% of its total volumetric snowfall by end-of-century under the high-emissions SSP3-7.0 scenario, but 25±6% and 17±6% under the lower-emissions SSP2-4.5 and SSP1-2.6 scenarios.
Voriconazole-induced periostitis in a child with finger pain and nodules: case report and literature review
Authors: Urakawa Hiroshi , Ikuta Kunihiro , Sakai Tomohisa , Koike Hiroshi , Fujito Takeo , Nishida Yoshihiro , Imagama Shiro 
Published: July 2024

Abstract

Background
Voriconazole-induced periostitis is predominantly reported in adults, with pediatric cases being exceedingly rare.
Case presentation:
This report describes an 8-year-old boy with voriconazole-induced periostitis presenting with finger pain and nodules, initially suspected to be bone tumors. The patient had been on voriconazole for three years to treat Aspergillus pneumonia and had been hospitalized for six months due to chronic graft-versus-host disease following hematopoietic stem cell transplantation and total body irradiation for severe congenital neutropenia. The patient presented with a five-month history of pain and a one-month history of a mass in the middle finger of his right hand. Radiographs revealed bone formation outside the cortical bone in the proximal phalanx of the right middle finger and the distal ulna. Differential diagnoses included benign bone-forming tumors, such as osteochondroma post-total body irradiation, and bizarre parosteal osteochondromatous proliferation. The diagnosis of voriconazole-induced periostitis was confirmed as multiple bone lesions and new bone formation became apparent during the disease course.
Conclusions
Voriconazole-induced periostitis should be considered, even in pediatric patients, when multiple nodular periosteal reactions are observed in immunosuppressed patients undergoing long-term voriconazole therapy.
Unveiling the Uncommon: Fallopian Tube Cavernous Hemangioma in pregnancy with endometriosis background – a case report and literature review
Authors: Ntalianis Konstantinos Malligiannis , Hulipas Gladys , Mohanraj Hemapriya , Resta Christina Anastasia , Nayar Anitha , Sathiyathasan Sahathevan 
Published: July 2024

Abstract

This case report presents a fallopian tube cavernous hemangioma, a highly rare benign tumour, which was found during a caesarean section. Previous medical and gynaecology histories involved endometriosis, adenomyosis, and irritable bowel syndrome. Fallopian tube hemangiomas are sporadic benign vascular tumours, with only 16 cases documented in the literature. These tumours are typically small, ranging from 5 mm to 30 mm in size. The aetiology of hemangiomas is still unclear, but it is commonly believed that the growth of fallopian tube hemangiomas is stimulated by oestrogens, which promote blood vessel growth. Most hemangiomas, which are mainly asymptomatic, are discovered incidentally during surgeries for other conditions or complications. To the best of our knowledge, we report the first ever case of cavernous haemangioma of the fallopian tube identified in pregnancy.
Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome
Authors: Jiang Yong-hui , Wang Sung Eun , Cheng Yubao , Lim Jaechul , Jang Mi-Ae , Forrest Emily , Kim Yuna , Donahue Meaghan , Qiao Sheng-Nan , Xiong Yan , Jin Jian , Wang Siyuan 
Published: July 2024

Abstract

Prader-Willi Syndrome (PWS) is caused by loss of expression of paternally expressed genes in the human 15q11.2-q13 imprinting domain. A set of imprinted genes that are active on the paternal but silenced on the maternal chromosome are intricately regulated by a bipartite imprinting center (PWS-IC) located in the PWS imprinting domain. In past work, we discovered that euchromatic histone lysine N-methyltransferase-2 (EHMT2/G9a) inhibitors were capable of un-silencing PWS-associated genes by restoring their expression from the maternal chromosome. Here, in mice lacking the Ehmt2 gene, we document unsilencing of the imprinted Snrpn/Snhg14 gene on the maternal chromosome in the late embryonic and postnatal brain. Using PWS and Angelman syndrome patient derived cells with either paternal or maternal deletion of 15q11-q13, we have found that chromatin of maternal PWS-IC is closed and has compact 3D folding confirmation. We further show that a new and distinct noncoding RNA preferentially transcribed from upstream of the PWS-IC interacts with EHMT2 and forms a heterochromatin complex to silence gene expression of SNRPN in CIS on maternal chromosome. Taken together, these findings demonstrate that allele-specific recruitment of EHMT2 is required to maintain the maternal imprints. Our findings provide novel mechanistic insights and support a new model for imprinting maintenance of the PWS imprinted
domain.
Evaluating LRRC15 as a Dual Prognostic and Therapeutic Biomarker in Glioma
Authors: Zhu Junrou , Wang Heng , Wang Haiyang , Zhang Li , Zhang keyang , Xue Letian , Yu Wenhua 
Published: July 2024

Abstract

Background Glioma is the most common type of malignant brain tumor, presenting substantial treatment challenges. LRRC15, a leucine-rich repeat (LRR) protein and a type I transmembrane protein, has been linked to cancer progression but its specific role in glioma has not been fully elucidated.Methods This research examined LRRC15 expression in various cancers with a focus on glioma, utilizing data from The Cancer Genome Atlas (TCGA). We explored the correlation between LRRC15 expression and survival (both overall and disease-specific) in glioma patients, and investigated the relationship of LRRC15 with immune cell infiltration in the tumor microenvironment. Functional impacts of LRRC15 on glioma cell proliferation, motility, and invasiveness were assessed through colony formation assays, transwell migration tests, and wound healing assays.Results LRRC15 expression was notably elevated in glioma among other cancers. Higher levels of LRRC15 correlated with adverse survival outcomes in glioma patients. Functionally, reducing LRRC15 expression in glioma cell lines diminished their proliferative, motile, and invasive properties.Conclusions Our findings highlight LRRC15 as a significant prognostic biomarker and potential therapeutic target in glioma. Inhibiting LRRC15 could decelerate tumor progression and enhance clinical outcomes, representing a promising advancement in glioma therapy.