bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic susceptibility and geochemical characterization of an upper Mississippian cyclothemic section Polotnyanyi Zavod, (Moscow Basin, Russia)
Authors: Alekseev A. O. , Kabanov P. B. , Alekseeva T. V. , Kalinin P. I. 
Published: January 2015

Abstract

This case study provides insight into magnetic susceptibility (MS), iron and bulk-sample geochemistry patterns in an Upper Mississippian siliciclastic–carbonate cyclothemic section Polotnyanyi Zavod (Moscow Basin, Russia), with many subaerial disconformities and
Stigmaria
impressions. The goal of this paper is to test whether the MS and geochemical signals in this section are linked to any specific geological processes. The section is dominated by limestones but contains several siliciclastic units and numerous subaerial disconformities. This lithological heterogeneity is vividly expressed on MS and bulk geochemical logs. MS shows the strongest positive correlation to bulk iron and also strong correlations to Al
2
O
3
, MgO, K
2
O and TiO
2
, pointing to close association of iron with siliciclastic fines rich in detrital mica and clays. The correlation of iron and MS to siliciclastic fines or subaerial exposure horizons is not straightforward. The highest ferruginization with most intense MS excursions occurs in basal sooty silts and shales of three main siliciclastic units of the studied section. In addition, many other thin pedogenized shales are ferruginized and show a relative high magnetism, but some ferruginized shales are not palaeosols.
Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production
Authors: Chafe Shawn C. , Lou Yuanmei , Sceneay Jaclyn , Vallejo Marylou , Hamilton Melisa J. , McDonald Paul C. , Bennewith Kevin L. , Möller Andreas , Dedhar Shoukat 
Published: January 2015

Abstract
The mobilization of bone marrow–derived cells (BMDC) to distant tissues before the arrival of disseminated tumor cells has been shown preclinically to facilitate metastasis through the establishment of metastatic niches. Primary tumor hypoxia has been demonstrated to play a pivotal role in the production of chemokines and cytokines responsible for the mobilization of these BMDCs, especially in breast cancer. Carbonic anhydrase IX (CAIX, CA9) expression is highly upregulated in hypoxic breast cancer cells through the action of hypoxia-inducible factor-1 (HIF1). Preclinical evidence has demonstrated that CAIX is required for breast tumor growth and metastasis; however, the mechanism by which CAIX exerts its prometastatic function is not well understood. Here, we show that CAIX is indispensable for the production of granulocyte colony-stimulating factor (G-CSF) by hypoxic breast cancer cells and tumors in an orthotopic model. Furthermore, we demonstrate that tumor-expressed CAIX is required for the G-CSF–driven mobilization of granulocytic myeloid-derived suppressor cells (MDSC) to the breast cancer lung metastatic niche. We also determined that CAIX expression is required for the activation of NF-κB in hypoxic breast cancer cells and constitutive activation of the NF-κB pathway in CAIX-depleted cells restored G-CSF secretion. Together, these findings identify a novel hypoxia-induced CAIX–NF-κB–G-CSF cellular signaling axis culminating in the mobilization of granulocytic MDSCs to the breast cancer lung metastatic niche. Cancer Res; 75(6); 996–1008. ©2015 AACR.
Human Papillomavirus 16 E6 Antibodies in Individuals without Diagnosed Cancer: A Pooled Analysis
Authors: Lang Kuhs Krystle A. , Anantharaman Devasena , Waterboer Tim , Johansson Mattias , Brennan Paul , Michel Angelika , Willhauck-Fleckenstein Martina , Purdue Mark P. , Holcátová Ivana , Ahrens Wolfgang , Lagiou Pagona , Polesel Jerry , Simonato Lorenzo , Merletti Franco , Healy Claire M. , Kjaerheim Kristina , Conway David I. , Macfarlane Tatiana V. , Thomson Peter , Castellsagué Xavier , Znaor Ariana , Black Amanda , Huang Wen-Yi , Krogh Vittorio , Trichopoulou Antonia , Bueno-de-Mesquita H. B(as). , Clavel-Chapelon Françoise , Weiderpass Elisabete , Ekström Johanna , Riboli Elio , Tjønneland Anne , Sánchez María-José , Travis Ruth C. , Hildesheim Allan , Pawlita Michael , Kreimer Aimée R. 
Published: January 2015

Abstract
Background: The increasing incidence of oropharyngeal cancer in many developed countries has been attributed to human papillomavirus type 16 (HPV16) infections. Recently, HPV16 E6 serology has been identified as a promising early marker for oropharyngeal cancer. Therefore, characterization of HPV16 E6 seropositivity among individuals without cancer is warranted.
Methods: A total of 4,666 controls were pooled from several studies of cancer and HPV seropositivity, all tested within the same laboratory. HPV16 E6 seropositive controls were classified as having (i) moderate [mean fluorescent intensity (MFI) ≥ 484 and &lt;1,000] or (ii) high seroreactivity (MFI ≥ 1,000). Associations of moderate and high HPV16 E6 seroreactivity with (i) demographic risk factors; and seropositivity for (ii) other HPV16 proteins (E1, E2, E4, E7, and L1), and (iii) E6 proteins from non-HPV16 types (HPV6, 11, 18, 31, 33, 45, and 52) were evaluated.
Results: Thirty-two (0.7%) HPV16 E6 seropositive controls were identified; 17 (0.4%) with moderate and 15 (0.3%) with high seroreactivity. High HPV16 E6 seroreactivity was associated with former smoking [odds ratio (OR), 5.5; 95% confidence interval (CI), 1.2–51.8], and seropositivity against HPV16 L1 (OR, 4.8; 95% CI, 1.3–15.4); E2 (OR, 7.7; 95% CI, 1.4–29.1); multiple HPV16 proteins (OR, 25.3; 95% CI, 2.6–119.6 for three HPV16 proteins beside E6) and HPV33 E6 (OR, 17.7; 95% CI, 1.9–81.8). No associations were observed with moderate HPV16 E6 seroreactivity.
Conclusions: High HPV16 E6 seroreactivity is rare among individuals without diagnosed cancer and was not explained by demographic factors.
Impact: Some HPV16 E6 seropositive individuals without diagnosed HPV-driven cancer, especially those with seropositivity against other HPV16 proteins, may harbor a biologically relevant HPV16 infection. Cancer Epidemiol Biomarkers Prev; 24(4); 683–9. ©2015 AACR.
Very Long-term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis
Authors: Dal Molin Marco , Zhang Ming , de Wilde Roeland F. , Ottenhof Niki A. , Rezaee Neda , Wolfgang Christopher L. , Blackford Amanda , Vogelstein Bert , Kinzler Kenneth W. , Papadopoulos Nickolas , Hruban Ralph H. , Maitra Anirban , Wood Laura D. 
Published: January 2015

Abstract
Purpose: The median survival following surgical resection of pancreatic ductal adenocarcinoma (PDAC) is currently &lt;20 months. However, survival ≥10 years is achieved by a small subset of patients who are defined as very long-term survivors (VLTS). The goal of this study was to determine whether specific genetic alterations in resected PDACs determined very long-term survival.
Experimental Design: We sequenced the exomes of eight PDACs from patients who survived ≥10 years. On the basis of the results of the exomic analysis, targeted sequencing of selected genes was performed in a series of 27 additional PDACs from VLTSs.
Results: KRAS mutations were identified in 33 of 35 cancers (94%) from VLTSs and represented the most prevalent alteration in our cohort. TP53, SMAD4, and CDKN2A mutations occurred in 69%, 26%, and 17%, respectively. Mutations in RNF43, which have been previously associated with intraductal papillary mucinous neoplasms, were identified in four of the 35 cancers (11%). Taken together, our data show no difference in somatic mutations in carcinomas from VLTSs compared with available data from PDACs unselected for survival. Comparison of clinicopathologic features between VLTSs and a matching control group demonstrated that younger age, earlier stage, well/moderate grade of differentiation, and negative resection margins were associated with VLTS. However, more advanced stage, poor grade, or nodal disease did not preclude long-term survival.
Conclusions: Our results suggest that in most patients, somatic mutations in commonly mutated genes are unlikely to be the primary determinant of very long-term survival following surgical resection of PDAC. Clin Cancer Res; 21(8); 1944–50. ©2015 AACR.
Id1 Deficiency Protects against Tumor Formation in ApcMin/+ Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer
Authors: Zhang Ning , Subbaramaiah Kotha , Yantiss Rhonda K. , Zhou Xi Kathy , Chin Yvette , Benezra Robert , Dannenberg Andrew J. 
Published: January 2015

Abstract
Different mechanisms contribute to the development of sporadic, hereditary and colitis-associated colorectal cancer. Inhibitor of DNA binding/differentiation (Id) proteins act as dominant-negative antagonists of basic helix–loop–helix transcription factors. Id1 is a promising target for cancer therapy, but little is known about its role in the development of colon cancer. We used immunohistochemistry to demonstrate that Id1 is overexpressed in human colorectal adenomas and carcinomas, whether sporadic or syndromic. Furthermore, elevated Id1 levels were found in dysplasia and colon cancer arising in patients with inflammatory bowel disease. Because levels of PGE2 are also elevated in both colitis and colorectal neoplasia, we determined whether PGE2 could induce Id1. PGE2 via EP4 stimulated protein kinase A activity resulting in enhanced pCREB-mediated Id1 transcription in human colonocytes. To determine the role of Id1 in carcinogenesis, two mouse models were used. Consistent with the findings in humans, Id1 was overexpressed in tumors arising in both ApcMin/+ mice, a model of familial adenomatous polyposis, and in experimental colitis-associated colorectal neoplasia. Id1 deficiency led to significant decrease in the number of intestinal tumors in ApcMin/+ mice and prolonged survival. In contrast, Id1 deficiency did not affect the number or size of tumors in the model of colitis-associated colorectal neoplasia, likely due to exacerbation of colitis associated with Id1 loss. Collectively, these results suggest that Id1 plays a role in gastrointestinal carcinogenesis. Our findings also highlight the need for different strategies to reduce the risk of colitis-associated colorectal cancer compared with sporadic or hereditary colorectal cancer. Cancer Prev Res; 8(4); 303–11. ©2015 AACR.
Induced PD-L1 Expression Mediates Acquired Resistance to Agonistic Anti-CD40 Treatment
Authors: Zippelius Alfred , Schreiner Jens , Herzig Petra , Müller Philipp 
Published: January 2015

Abstract
CD40 stimulation on antigen-presenting cells (APC) allows direct activation of CD8+ cytotoxic T cells, independent of CD4+ T-cell help. Agonistic anti-CD40 antibodies have been demonstrated to induce beneficial antitumor T-cell responses in mouse models of cancer and early clinical trials. We report here that anti-CD40 treatment induces programmed death ligand-1 (PD-L1) upregulation on tumor-infiltrating monocytes and macrophages, which was strictly dependent on T cells and IFNγ. PD-L1 expression could be counteracted by coadministration of antibodies blocking the PD-1 (programmed death-1)/PD-L1 axis as shown for T cells from tumor models and human donors. The combined treatment was highly synergistic and induced complete tumor rejection in about 50% of mice bearing MC-38 colon and EMT-6 breast tumors. Mechanistically, this was reflected by a strong increase of IFNγ and granzyme-B production in intratumoral CD8+ T cells. Concomitant CTLA-4 blockade further improved rejection of established tumors in mice. This study uncovers a novel mechanism of acquired resistance upon agonistic CD40 stimulation and proposes that the concomitant blockade of the PD-1/PD-L1 axis is a viable therapeutic strategy to optimize clinical outcomes. Cancer Immunol Res; 3(3); 236–44. ©2015 AACR.
Hyperlipidemia in Early Adulthood Increases Long-Term Risk of Coronary Heart Disease
Authors: Navar-Boggan Ann Marie , Peterson Eric D. , D’Agostino Ralph B. , Neely Benjamin , Sniderman Allan D. , Pencina Michael J. 
Published: January 2015

Background—
Many young adults with moderate hyperlipidemia do not meet statin treatment criteria under the new American Heart Association/American College of Cardiology cholesterol guidelines because they focus on 10-year cardiovascular risk. We evaluated the association between years of exposure to hypercholesterolemia in early adulthood and future coronary heart disease (CHD) risk.

Methods and Results—

We examined Framingham Offspring Cohort data to identify adults without incident cardiovascular disease to 55 years of age (n=1478), and explored the association between duration of moderate hyperlipidemia (non–high-density lipoprotein cholesterol≥160 mg/dL) in early adulthood and subsequent CHD. At median 15-year follow-up, CHD rates were significantly elevated among adults with prolonged hyperlipidemia exposure by 55 years of age: 4.4% for those with no exposure, 8.1% for those with 1 to 10 years of exposure, and 16.5% for those with 11 to 20 years of exposure (
P
<0.001); this association persisted after adjustment for other cardiac risk factors including non–high-density lipoprotein cholesterol at 55 years of age (hazard ratio, 1.39; 95% confidence interval, 1.05–1.85 per decade of hyperlipidemia). Overall, 85% of young adults with prolonged hyperlipidemia would not have been recommended for statin therapy at 40 years of age under current national guidelines. However, among those not considered statin therapy candidates at 55 years of age, there remained a significant association between cumulative exposure to hyperlipidemia in young adulthood and subsequent CHD risk (adjusted hazard ratio, 1.67; 95% confidence interval, 1.06–2.64).

Conclusions—
Cumulative exposure to hyperlipidemia in young adulthood increases the subsequent risk of CHD in a dose-dependent fashion. Adults with prolonged exposure to even moderate elevations in non–high-density lipoprotein cholesterol have elevated risk for future CHD and may benefit from more aggressive primary prevention.
Projected Changes in Climate Extremes over the Northeastern United States
Authors: Ning Liang , Riddle Emily E. , Bradley Raymond S. 
Published: January 2015

AbstractProjections of historical and future changes in climate extremes are examined by applying the bias-correction spatial disaggregation (BCSD) statistical downscaling method to five general circulation models (GCMs) from phase 5 of the Coupled Model Intercomparison Project (CMIP5). For this analysis, 11 extreme temperature and precipitation indices that are relevant across multiple disciplines (e.g., agriculture and conservation) are chosen. Over the historical period, the simulated means, variances, and cumulative distribution functions (CDFs) of each of the 11 indices are first compared with observations, and the performance of the downscaling method is quantitatively evaluated. For the future period, the ensemble average of the five GCM simulations points to more warm extremes, fewer cold extremes, and more precipitation extremes with greater intensities under all three scenarios. The changes are larger under higher emissions scenarios. The inter-GCM uncertainties and changes in probability distributions are also assessed. Changes in the probability distributions indicate an increase in both the number and interannual variability of future climate extreme events. The potential deficiencies of the method in projecting future extremes are also discussed.
Observational Evidence that Great Plains Irrigation Has Enhanced Summer Precipitation Intensity and Totals in the Midwestern United States
Authors: Alter Ross E. , Fan Ying , Lintner Benjamin R. , Weaver Christopher P. 
Published: January 2015

AbstractSignificant increases in summer precipitation have occurred in the midwestern United States over the last century for reasons that remain unclear. It is postulated that the expansion of irrigation and cropland in the central United States over the past 60 yr has been a major contributor to these observed increases in precipitation. As a first step toward attribution of these precipitation changes, a detailed analysis of observed daily summer precipitation frequency and intensity is conducted for the contiguous United States over multiple spatial scales and time periods from 1895 to 2011. Robust increases in precipitation frequency, total precipitation, and moderate to heavy precipitation intensity are identified during July and August in the midwestern United States. Analysis of changes in mean monthly precipitation from the early to late twentieth century initially points to increasing frequency as the source of increasing monthly precipitation in the midwestern United States during the summer, especially during August; however, these large frequency increases are not unique to the summer. On the other hand, changes in precipitation intensity and total precipitation are both greatest during July and August and coincide spatially in the midwestern United States. Additionally, the greatest intensity change occurs downwind of the most heavily irrigated regions, especially for the period between 1950 and 1980 when irrigation rapidly intensified. Thus, the seasonality and location of these regional signatures of increasing precipitation intensity (and total precipitation) are found to be broadly consistent with spatiotemporal trends in irrigation and cropland in the central United States and may be indicative of a causal link.
Radar Remote Sensing Estimates of Waves and Wave Forcing at a Tidal Inlet
Authors: Díaz Méndez Guillermo M. , Haller Merrick C. , Raubenheimer Britt , Elgar Steve , Honegger David A. 
Published: January 2015

AbstractThe time and space variability of wave transformation through a tidal inlet is investigated with radar remote sensing. The frequency of wave breaking and the net wave breaking dissipation at high spatial resolution is estimated using image sequences acquired with a land-based X-band marine radar. Using the radar intensity data, transformed to normalized radar cross section σ0, the temporal and spatial distributions of wave breaking are identified using a threshold developed via the data probability density function. In addition, the inlet bathymetry is determined via depth inversion of the radar-derived frequencies and wavenumbers of the surface waves using a preexisting algorithm (cBathy). Wave height transformation is calculated through the 1D cross-shore energy flux equation incorporating the radar-estimated breaking distribution and bathymetry. The accuracy of the methodology is tested by comparison with in situ wave height observations over a 9-day period, obtaining correlation values R = 0.68 to 0.96, and root-mean-square errors from 0.05 to 0.19 m. Predicted wave forcing, computed as the along-inlet gradient of the cross-shore radiation stress was onshore during high-wave conditions, in good agreement (R = 0.95) with observations.
Influence of graphene on the cell morphology and mechanical properties of extruded polystyrene foam
Authors: Okolieocha Chimezie , Köppl Thomas , Kerling Sabrina , Tölle Folke J , Fathi Amir , Mülhaupt Rolf , Altstädt Volker 
Published: January 2015

The incorporation of nanoparticles to polymer foams not only reinforces the cell walls and struts but can also lead to a decrease of cell size and enhanced cell morphology which in turn, yield foams with superior mechanical properties. For this purpose, several studies have focused on identifying close-to-ideal nucleating agents as well as understanding the influence of processing parameters on foam cell morphology. This research provides a systemic approach to low-density polystyrene foams produced with graphene (thermally reduced graphite oxide), talc and carbon nanotubes (MWCNTs) via foam extrusion. Remarkably, the cell morphologies of polystyrene/thermally reduced graphite oxide foams show enhanced cell homogeneity with a tremendous increase of the cell densities by more than one order of magnitude compared to neat polystyrene and its counterparts.
Safety of Modified Coronal Approach with Dissection Deep to Temporalis Fascia for Facial Nerve Preservation
Authors: Kleinberger Andrew J. , Jumaily Jeffrey , Spiegel Jeffrey H. 
Published: January 2015

ObjectiveTo evaluate the safety of a modified coronal approach to the upper craniofacial skeleton with dissection deep to the temporalis fascia for enhanced preservation of the frontal branch of the facial nerve.Study DesignCase series with chart review.SettingTertiary academic medical center.Subjects and MethodsIn total, 271 patients undergoing coronal flap approaches to the upper craniofacial skeleton by a single surgeon from January 2008 through December 2013 were included. Primary outcomes are temporary or permanent weakness of the frontal branch of the facial nerve as well as the incidence of temporal hollowing following surgery. Secondary outcomes include the presence of postoperative hematoma, seroma, infection, scarring, and alopecia.ResultsThere were no cases involving either temporary or permanent facial nerve weakness. The incidence of other postoperative complications was also exceedingly low, including a hematoma rate of less than 1%, widened scarring in 2.6% of patients, and no cases of clinically significant temporal hollowing encountered during a mean follow‐up period of 3 years.ConclusionA modified coronal approach with dissection deep to the temporalis fascia offers a safe and reliable surgical technique for accessing the upper craniofacial skeleton. Observed complications were minimal, and despite this deeper plane of dissection, there were no cases of either temporary or permanent facial nerve weakness in a large retrospective series of patients from over the past 6 years. Consideration should be given for the routine use of this modified coronal approach for both reconstructive as well as cosmetic indications.