bluuebunny/crossref_metadata_2025_split huggingface dataset:
The 24‐year course of substance use disorders in patients with borderline personality disorder and personality‐disordered comparison subjects
Authors: Zanarini Mary C. , Temes Christina M. , Glass Isabel V. , Frankenburg Frances R. , Fitzmaurice Garrett M. , Unruh Brandon T. , Weiss Roger D. 
Published: February 2025

AbstractBackground and ObjectivesThe purpose of this study is to detail the long‐term course of substance use disorders (SUDs) among patients with borderline personality disorder (BPD) and subjects with other personality disorders (OPD).MethodsTwo hundred and ninety patients with BPD and 72 subjects with OPD were assessed at baseline and 12 contiguous waves of follow‐up as part of the McLean Study of Adult Development (MSAD). The SCID‐I for DSM‐III‐R Axis I disorders was administered 13 times (at baseline admission and at 12 follow‐up periods). Kaplan–Meier analyses were used to assess time‐to‐remission (2–12 years in length), time‐to‐recurrence (2–12 years after first remission), and cumulative time‐to‐new onsets of alcohol and drug use disorders.ResultsBoth study groups achieved high rates of remission (ranging from 12‐year long to 2‐year long) from alcohol use disorder (AUD) (BPD: 64%–91%; OPD: 80%–100%) and drug use disorder (DUD) (BPD: 71%–100%; OPD: 75%–100%). Recurrences (following 12‐year long and 2‐year long remissions) of AUD (BPD: 24%–63%; OPD: 46%–70%) and DUD (BPD: 28%–67%; OPD: 0%–38%) were not uncommon. Cumulative rates of new onsets during the 24 years of prospective follow‐up of AUD (BPD: 5%–27%; OPD: 2%–10%) and DUD (BPD: 5%–21%; OPD: 7%–18%) were less common.Discussion and ConclusionsRemissions of alcohol and drug use disorders among borderline patients are very common but recurrences are not uncommon. Results also suggest that new onsets of these disorders are relatively rare.Scientific SignificanceThe course of SUDs in those with BPD is more complex than found in prior shorter‐term studies.
Fine‐tuning established morphometric models through citizen science data
Authors: Biskis Veronika N. , Townsend Kathy A. , Morgan David L. , Lear Karissa O. , Holmes Bonnie J. , Wueringer Barbara E. 
Published: February 2025

AbstractFor globally threatened species, patchy data pose challenges in both establishing historical baselines and assessing current distributions. In the case of sawfishes, much previous research has relied on amputated trophy rostra or historical photographs to fill data gaps in distribution and population estimates. However, the established morphometric models that allow the estimation of total length from rostra are restricted by the data available to generate them, with many constructed solely from juvenile morphometric data, and robust error testing rarely performed. This study generates an independent dataset from citizen science photographs and field measurements, incorporating sawfishes of all life history stages, to test the robustness of previously proposed models for the four Indo‐Pacific sawfish species. Rostrum‐to‐length morphometric models (RLMs) were confirmed for Pristis clavata and Pristis pristis, and a new model was proposed for Pristis zijsron. A key source of error in previous RLMs for Anoxypristis cuspidata was identified as changing rostrum morphology with body size, but there were insufficient measurements in the present dataset to propose a new robust model for this species. This study highlights the problems associated with extrapolating total lengths of animals beyond the size bounds used to produce the original model. For historically exploited species like sawfishes, which are often represented in collections by trophies alone, these methods outline a critical step prior to use in further ecological study.
Sex‐Related Differences in Outcomes of Endovascular Treatment in Large Vessel Occlusion Stroke—Analyses From the German Stroke Registry‐Endovascular Treatment
Authors: Single Constanze , Mengel Annerose , Laichinger Kornelia , Sartor‐Pfeiffer Jennifer , Selo Nadja , Hennersdorf Florian , Bender Benjamin , Deb‐Chatterji Milani , Thomalla Götz , Mbroh Joshua , Poli Sven , Ziemann Ulf , Ernemann Ulrike , Feil Katharina ,   German Stroke Registry—Endovascular Treatment (GSR)
Published: February 2025

ABSTRACTBackgroundSex‐related differences in acute ischemic stroke may affect outcomes, yet evidence remains inconsistent. This large‐scale study investigated sex‐related differences in clinical presentation, peri‐interventional parameters, and outcomes after endovascular thrombectomy (EVT) for large vessel occlusion (LVO) using data from the German Stroke Registry—Endovascular Treatment (GSR‐ET).MethodsWe analyzed 11.896 EVT patients (52.2% female) from the GSR‐ET (June 2015–December 2021) comparing clinical characteristics, treatment details, and outcomes by sex. Two propensity score matchings (PSM) were applied: (1) logistic regression model with a caliper width of 0.1 on age, pre‐stroke modified Rankin Scale (pmRS), and National Institutes of Health Stroke Scale at admission, and (2) 1:1 nearest neighbor matching with a caliper of 0.01. Primary outcomes were good (mRS 0–2) and excellent (mRS 0–1) outcomes at discharge and 90‐day follow‐up.ResultsWomen were older (76.3 ± 12.7 vs. 70.2 ± 12.9 years, p < 0.001) and had higher pre‐stroke disability (median pmRS 0 (0, 2) vs. 0 (0, 1), p < 0.001). Cardioembolic strokes were more frequent in women, even after PSM. Despite this, women had better odds of achieving good outcomes at discharge (adjusted OR 1.20, 95% CI 1.04–1.38, p = 0.013), but not at follow‐up (OR 0.91, 95% CI 0.78–1.05, p = 0.193). Both PSM analyses confirmed these findings.ConclusionsWhile women demonstrated better short‐term functional outcomes after EVT, these benefits diminished in follow‐up. The persistence of cardioembolic stroke in women suggests potential sex‐specific mechanisms. Understanding and addressing sex‐related differences in stroke is essential to optimize acute stroke care and improve outcomes. Future studies should explore biological and socio‐economic factors influencing sex‐related differences.Trial RegistrationClinicalTrials.gov identifier: NCT03356392
Assessing the Therapeutic Value of Primary Tumor Resection in Colorectal Cancer Lung Metastases: A Dynamic Visualization Clinical Tool Constructed Based on the SEER Database
Authors: Xu Jinyi , Niu Xiaoqiang 
Published: February 2025

ABSTRACTBackgroundThe efficacy of primary tumor resection (PTR) for colorectal cancer lung metastases (CRLM) is unclear. This study used the SEER database to investigate if PTR improves prognosis in CRLM patients and developed a nomogram to predict the likelihood of benefiting from PTR.MethodsPatients with CRLM from the SEER database (2010–2019) were included. Propensity score matching (PSM) balanced PTR and non‐PTR groups. Kaplan–Meier analysis compared overall and cancer‐specific survival. Cox regression identified survival factors. The PTR group was divided into training and validation sets (7:3 ratio) for nomogram development using logistic regression. Nomogram performance was validated using ROC curves, calibration curves, and decision curve analysis.ResultsA total of 3264 CRLM patients were included (2459 with PTR, 805 without). After 1:1 PSM, each group had 484 patients. PTR significantly improved survival (p < 0.001). Logistic regression identified age, race, T‐stage, chemotherapy, and metastases to the liver, brain, and bone as risk factors. The nomogram showed excellent predictive performance and clinical utility.ConclusionPTR improves survival in CRLM patients, and the nomogram effectively predicts the benefit of PTR.
Association of early versus late tracheostomy with prognosis in hypoxic‐ischaemic encephalopathy patients: A propensity‐matched cohort study
Authors: Li Yeling , Wan Dingyuan , Liu Hongmei , Guo Keying , Liu Yilin , Zhao Lihong , Li Ming , Li Jijie , Liu Yiwen , Dong Wei 
Published: February 2025

AbstractBackgroundThe optimal timing for exchanging an endotracheal tube for a tracheostomy cannula in patients with hypoxic‐ischaemic encephalopathy is controversial.AimThis study aimed to evaluate the effects of early versus late tracheostomy on the prognosis of patients with hypoxic‐ischaemic encephalopathy.Study DesignThe study was an observational retrospective study that followed the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. We included adults with hypoxic‐ischaemic encephalopathy who underwent tracheostomy between January 2012 and September 2020. The patients were classified into early or late tracheostomy groups. To eliminate differences in baseline characteristics, propensity score matching was conducted, and the outcomes between the two groups were compared.ResultsA total of 132 patients were included, and through propensity score matching, 54 pairs of patients were matched. The early tracheostomy group showed a significant reduction in the duration of mechanical ventilation (median, 12 days; interquartile range 7–20 vs. median, 28 days; interquartile range, 15.75–58.25, p < .001), intensive care unit length of stay (median, 14.5 days; interquartile range, 6.75–26 vs. median, 35 days; interquartile range, 20–59, p < .001) and hospital length of stay (median, 19.5 days; interquartile range, 10.87–36.5 vs. median, 39.5 days; interquartile range, 22–66, p < .001). Over a 1‐year follow‐up period, there were no significant differences between the two groups regarding inhospital mortality (57.4% vs. 46.3%, p = .248), 30‐day mortality (59.3% vs. 46.3%, p = .177) and 1‐year mortality (61.1% vs. 48.1%, p = .176).ConclusionsIn patients with hypoxic‐ischaemic encephalopathy undergoing mechanical ventilation, early tracheostomy is associated with a reduction in the duration of mechanical ventilation and decreased intensive care unit and hospital length of stay.Relevance to Clinical PracticeFor patients with hypoxic‐ischaemic encephalopathy who are at a high risk of requiring prolonged mechanical ventilation, the benefits of early tracheostomy suggest considering it a viable treatment option.
Effectiveness of self-management digital interventions in improving health-related outcomes in patients with chronic obstructive pulmonary disease: an umbrella review protocol
Authors: Salgado Ricardo , Fernandes Hugo , de Goumoëns Véronique , Kiszio Blanche , Costa Patrício , Delmas Philippe , Padilha Miguel 
Published: February 2025

Objective:
This review will aim to assess the effectiveness of self-management digital interventions in improving health-related outcomes in patients with chronic obstructive pulmonary disease (COPD).

Introduction:
Respiratory rehabilitation programs that promote self-management are crucial for COPD patients. However, current face-to-face strategies involve challenges, such as low participation, high dropout rates, and short-lived post-intervention benefits. Digital self-management interventions may address these issues by improving access to support and enhancing health-related outcomes. Several systematic reviews have examined the effectiveness of these interventions in improving health-related outcomes, prompting the current umbrella review to summarize the existing evidence.

Inclusion criteria:
This review will consider systematic reviews that examine the effectiveness of self-management digital interventions in improving health-related outcomes in COPD patients. It will not be restricted by COPD stage, phase, comorbidity, sex or gender, setting, or context.

Methods:
The JBI methodology for umbrella reviews will be followed. A comprehensive search will be conducted in PubMed, Embase, Cochrane Database of Systematic Reviews, CINAHL, PEDro, the International Network of Agencies for Health Technology Assessment, Epistemonikos, Web of Science, ProQuest, and COPD-related websites to identify reviews published in any language from inception to date. Titles and abstracts, and then full texts, will be screened independently by 2 reviewers against the inclusion criteria. Methodological quality will be assessed using the JBI critical appraisal checklist for systematic reviews and research syntheses. Data will be extracted using an adapted and piloted JBI data extraction tool. The findings will be presented in tabular format, along with narrative descriptions and visual support. A citation matrix will be produced to assess study overlap.

Umbrella review registration:
PROSPERO CRD42024517476
Multidisciplinary Modeling and Control Co-Design of a Floating Offshore Vertical-Axis Wind Turbine System
Authors: Lee Yong Hoon , Bayat Saeid , Allison James T. , Hossain Md Sanower , Griffith D. Todd 
Published: February 2025

Abstract
This study investigates the modeling and design of a floating vertical-axis wind turbine (FloatVAWT) system with multidisciplinary design optimization (MDO) and control co-design (CCD) approaches. By integrating various associated disciplinary models, the study aims to holistically optimize the physical and control designs of the FloatVAWT system. Through the identification of impactful design elements and capitalizing on synergistic interactions, the study aims to provide insights to subsystem designers and aid their detailed decisions. The model developed for this CCD framework utilizes automated geometric manipulation and mesh generation to explore various FloatVAWT configurations during the early design stages. Surrogate models facilitate efficient design studies within limited computing resources by exchanging model information between disciplinary models and subsystems without requiring extensive simulations during the optimization loop. The model incorporates an aero-hydro-servo dynamic representation of the FloatVAWT system, considering physical and control constraints. Additionally, the study investigates the potential benefits of varying both the average and intracycle rotational speeds of the vertical-axis wind turbine (VAWT) rotor to enhance energy production and minimize adverse platform motions, thus reducing the levelized cost of energy (LCOE). System-level design solutions are analyzed to identify design trade-offs and propose mitigation strategies for potential mechanical failures of the rotor. In conclusion, this study provides modeling strategies for the FloatVAWT system and analyzes the system design solutions through MDO and CCD approaches. The outcomes of the study offer insights into system-optimal solutions for subsystem-level decisions considering multidisciplinary couplings.
Acute Effects of Static Stretching on Handgrip Strength and Wrist Joint Flexibility in Physically Active Older Women
Authors: Palmer Ty B. , Palmer Bailey M. 
Published: February 2025

Background/Objective: The muscle strength and flexibility responses to stretching in older adults are unclear. We aimed to examine the acute effects of static stretching on handgrip strength and wrist joint flexibility in older women. Methods: Twenty physically active older women (68 ± 6 years) performed handgrip contractions and wrist joint flexibility assessments before and after a control condition (quiet resting) and an experimental condition of static stretching for 30 s. Peak force and rate of force development variables were obtained from each contraction. Wrist joint range of motion was determined from the flexibility assessments. Results: There were no significant changes in handgrip peak force or rate of force development variables after the stretching treatment (p = .11–.88). There was, however, a significant stretch-induced increase in wrist joint range of motion (p < .01). Conclusion: These findings indicate that a 30-s bout of static stretching may be an effective intervention for increasing wrist joint flexibility without decreasing handgrip strength. Significance/Implications: The results of our study may have important implications for creating stretching interventions that can be used as part of a warm-up routine to help attenuate the negative effects of age on range of motion. Such interventions may be beneficial for improving functional performance and reducing the risk of injury in older populations.
Child-, Family-, and Community-Level Correlates of 24-Hour Movement Behaviors in Ethiopian Young Children: The SUNRISE Study
Authors: Abdeta Chalchisa , Cliff Dylan , Kariippanon Katharina , Deksisa Alem , Garoma Sileshi , Tesfaye Debrework , Okely Anthony D. 
Published: February 2025

Background: Understanding the factors influencing 24-hour movement behaviors is important for designing appropriate health promotion strategies. We examined the multidimensional correlates of physical activity, sedentary behavior, screen time, and sleep among children under 5 years of age in Ethiopia. Methods: Cross-sectional study conducted in Adama and Lume district, Ethiopia. Children were recruited from urban kindergartens and rural villages. Physical activity, sedentary time, and sleep were assessed using accelerometry. Screen time and correlates were parent reported. Variables were selected a priori, using the social ecological model and considering country context. Linear mixed models were used to test associations between child-, family-, and community-level correlates and time spent in 24-hour movement behaviors, accounting for clustering effect. Results: Four hundred and thirty children participated (mean age 4.2 [0.6] y). Girls spent less time in total of physical activity (TPA) and moderate- to vigorous-intensity physical activity (MVPA) and more time sedentary than boys. Children who spent more time outdoors had higher TPA and MVPA, longer sleep duration, and shorter sedentary and screen time. Children of educated parents had lower TPA and MVPA and higher sedentary time than those with no formal education. Children of parents who reported using a screen device with their child for educational purposes spent less time in MVPA, had shorter sleep, and had more screen time than those who did not. Rural children had higher TPA and MVPA, longer sleep, and shorter sedentary and screen time than urban children. Conclusion: We identified key correlates of 24-hour movement behaviors in Ethiopian children. Designing tailored health promotion strategies to support healthy levels of movement behaviors, particularly in urban areas, is needed.
Cognitive, Affective, and Behavioral Approaches to the Formation of Individual Sport Fans’ Psychological Ownership and Its Impacts on Prosocial Behavior, Attendance Intention, and Psychological Well-Being
Authors: Park Seong-Jin , Lee Hyun-Woo 
Published: February 2025

The authors aimed to (a) investigate the underlying mechanism of how individual sport fans form psychological ownership using cognitive, affective, and behavioral approaches and (b) identify the outcomes of psychological ownership. Across three studies with between-subjects experimental designs (NCognitive-approach = 278; NAffective-approach = 436, NBehavioral-approach = 412), we revealed that fans in group-self-identification (vs. personal-self-identification) condition perceived a higher degree of empowerment, resulting in the formation of psychological ownership in all studies. Furthermore, we identified that prosocial behavior, attendance intention, and psychological well-being were the downstream consequences for psychological ownership. The results of the cross-validation analysis in Study 3 indicated no significant interaction effect of identification type (personal-self-identification vs. group-self-identification) and cultures (individualism vs. collectivism) on perceived empowerment. However, an additional three-way interaction analysis revealed a significant and negative conditional interaction effect only in the low collective identification group. Last, theoretical and practical implications were discussed based on these findings.
Multi-omics analysis reveals associations between gut microbiota and host transcriptome in colon cancer patients
Authors: Qin Yuling , Wang Qiang , Lin Qiumei , Liu Fengfei , Pan Xiaolan , Wei Caibiao , Chen Junxian , Huang Taijun , Fang Min , Yang Weilong , Pan Linghui 
Published: February 2025

ABSTRACT

Colon cancer (CC) is one of the most common cancers globally, which is associated with the gut microbiota intimately. In current research, exploring the complex interaction between microbiomes and CC is a hotspot. However, the information on microbiomes in most previous studies is based on fecal, which does not fully display the microbial environment of CC. Herein, we collected mucosal and tissue samples from both the tumor and normal regions of 19 CC patients and clarified the composition of mucosal microbiota by 16S rRNA and metagenomic sequencing. Additionally, RNA-Seq was also conducted to identify the different expression genes between tumor and normal tissue samples. We revealed significantly different microbial community structures and expression profiles to CC. Depending on correlation analysis, we demonstrated that 1,472 genes were significantly correlated with CC tumor microbiota. Our study reveals a significant enrichment of
Campylobacter jejuni
in the mucosa of CC, which correlates with bile secretion. Additionally, we observe a negative correlation between
C. jejuni
and immune cells CD4+ Tem and mast cells. Finally, we discovered that metabolic bacterial endosymbiont of
Bathymodiolus
sp.,
Bacillus wiedmannii
, and
Mycobacterium tuberculosis
had a significant survival value for CC, which was ignored by previous research. Overall, our study expands the understanding of the complex interplay between microbiota and CC and provides new targets for the treatment of CC.

IMPORTANCE

This study contributes to our understanding of the interaction between microbiota and colon cancer (CC). By examining mucosal and tissue samples rather than solely relying on fecal samples, we have uncovered previously unknown aspects of CC-associated microbiota. Our findings reveal distinct microbial community structures and gene expression profiles correlated with CC progression. Notably, the enrichment of
Campylobacter jejuni
in CC mucosa, linked to bile secretion, underscores potential mechanisms in CC pathogenesis. Additionally, observed correlations between microbial taxa and immune cell populations offer new avenues for immunotherapy research in CC. Importantly, this study introduces CC-associated microbiota with survival implications for CC, expanding therapeutic targets beyond conventional strategies. By elucidating these correlations, our study not only contributes to uncovering the potential role of gut microbiota in colon cancer but also establishes a foundation for mechanistic studies of gut microbiota in colon cancer, emphasizing the broader impact of microbiota research on cancer biology.