bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motion-induced blindness continues outside visual awareness and without attention
Authors: Dieter Kevin C. , Tadin Duje , Pearson Joel 
Published: July 2015

AbstractVisual phenomena demonstrating striking perceptual disappearances of salient stimuli have fascinated researchers because of their utility in identifying neural processes that underlie subjective visibility and invisibility. Motion-induced blindness (MIB) is appealing for such purposes because it, like a class of ostensibly related paradigms such as binocular rivalry, features periods of unequivocal subjective disappearances despite constant physical stimulation. It remains unclear, however, exactly how the mechanisms that cause MIB are related to subjectively observed fluctuations in visual awareness. To address this question, we used continuous flash suppression (CFS) to present the MIB stimulus outside visual awareness. Results indicated that MIB occasionally reappeared from suppression with its salient yellow target absent. To quantify this observation, we measured reaction times (RTs) to detect the yellow dot target following visible or perceptually suppressed MIB and indeed found no difference in RTs between these conditions. We also provide evidence that MIB fluctuations can occur without attention. In sum, these experiments indicate that MIB fluctuations are effectively changes in stimulus strength, which under typical conditions result in unmistakable subjective disappearances, but are not inherently fluctuations in stimulus visibility. More broadly, these results challenge the assumed privileged link between bistable stimuli and visual awareness.
Can plasmonic Al nanoparticles improve absorption in triple junction solar cells?
Authors: Yang L. , Pillai S. , Green M. A. 
Published: July 2015

AbstractPlasmonic nanoparticles located on the illuminated surface of a solar cell can perform the function of an antireflection layer, as well as a scattering layer, facilitating light-trapping. Al nanoparticles have recently been proposed to aid photocurrent enhancements in GaAs photodiodes in the wavelength region of 400–900 nm by mitigating any parasitic absorption losses. Because this spectral region corresponds to the top and middle sub-cell of a typical GaInP/GaInAs/Ge triple junction solar cell, in this work, we investigated the potential of similar periodic Al nanoparticles placed on top of a thin SiO2 spacer layer that can also serve as an antireflection coating at larger thicknesses. The particle period, diameter and the thickness of the oxide layers were optimised for the sub-cells using simulations to achieve the lowest reflection and maximum external quantum efficiencies. Our results highlight the importance of proper reference comparison and unlike previously published results, raise doubts regarding the effectiveness of Al plasmonic nanoparticles as a suitable front-side scattering medium for broadband efficiency enhancements when compared to standard single-layer antireflection coatings. However, by embedding the nanoparticles within the dielectric layer, they have the potential to perform better than an antireflection layer and provide enhanced response from both the sub-cells.
DNA methylation as a potential diagnosis indicator for rapid discrimination of rare cancer cells and normal cells
Authors: Si Xingyu , Zhao Yaoyao , Yang Chengdui , Zhang Sichun , Zhang Xinrong 
Published: July 2015

AbstractThe global DNA methylation degree may be a ubiquitous and early biomarker to distinguish cancer cells from benign cells. However, its usefulness in clinical diagnosis was scarcely demonstrated, because the cancer cells isolated from patients were usually very rare. Even if 10 mL of peripheral blood was sampled from a patient, only tens of cancer cells could be isolated. So a method to quantify DNA methylation from small number of cells was needed to apply DNA methylation in clinical environment. In this study, we found that normal breast cell line MCF10A and breast cancer cell line MCF7 cells present significantly different percentage of genomic 5-methylcytosine (p < 0.02, n = 8), it could be a potential indicator for rapid discrimination of rare cancer cells from normal cells. However, conventional mass spectrometry needs usually ~106 cells to quantify DNA methylation degree, which was too large to be applied in clinical diagnosis. Here we developed a fast mass spectrometry-based method capable of analyzing the DNA methylation degree from only ~100 human cells. Our method could reveal the different DNA methylation degree between MCF10A and MCF7 cells in less than two hours, having the potential to provide reliable information for clinical application.
Proteasome Accessory Factor C (pafC) Is a novel gene Involved in Mycobacterium Intrinsic Resistance to broad-spectrum antibiotics - Fluoroquinolones
Authors: Li Qiming , Xie Longxiang , Long Quanxin , Mao Jinxiao , Li Hui , Zhou Mingliang , Xie Jianping 
Published: July 2015

AbstractAntibiotics resistance poses catastrophic threat to global public health. Novel insights into the underlying mechanisms of action will inspire better measures to control drug resistance. Fluoroquinolones are potent and widely prescribed broad-spectrum antibiotics. Bacterial protein degradation pathways represent novel druggable target for the development of new classes of antibiotics. Mycobacteria proteasome accessory factor C (pafC), a component of bacterial proteasome, is involved in fluoroquinolones resistance. PafC deletion mutants are hypersensitive to fluoroquinolones, including moxifloxacin, norfloxacin, ofloxacin, ciprofloxacin, but not to other antibiotics such as isoniazid, rifampicin, spectinomycin, chloramphenicol, capreomycin. This phenotype can be restored by complementation. The pafC mutant is hypersensitive to H2O2 exposure. The iron chelator (bipyridyl) and a hydroxyl radical scavenger (thiourea) can abolish the difference. The finding that pafC is a novel intrinsic selective resistance gene provided new evidence for the bacterial protein degradation pathway as druggable target for the development of new class of antibiotics.
QoL analyses from INFORM study, a phase III study of gefitinib versus placebo as maintenance therapy in advanced NSCLC
Authors: Yang Yun-Peng , Ma Yu-Xiang , Huang Yan , Zhao Yuan-Yuan , Fang Wen-Feng , Hong Shao-Dong , Tian Ying , Xue Cong , Sheng Jin , Zhang Li 
Published: July 2015

AbstractThis report aimed to provide the full results of QoL assessment in INFORM study. QoL was assessed by FACT-L questionnaire. QoL improvement ratio in gefitinib arm was higher than placebo arm (FACT-L: 46% vs. 22%, p < 0.001; TOI: 41% vs. 18%, p < 0.001; LCS: 46% vs. 22%, p < 0.001). Gefitinib prolonged time-to-worsening of QoL (FACT-L: 2.8 m vs 1.4 m, p = 0.019; TOI: 3.5 m vs 1.4 m, p = 0.006; LCS: 2.8 vs 1.4 m, p = 0.028). Patients with an improvement in QoL had longer PFS (FACT-L: 9.4 m vs. 2.8 m vs. 2.7 m, P < 0.001; TOI: 9.9 m vs. 2.8 m vs. 2.1 m, P < 0.001; LCS: 9.4 m vs. 2.9 m vs. 2.1 m, P < 0.001) and OS (FACT-L: 25.4 m vs. 19.9 m vs. 14.4 m, P = 0.003; TOI: 25.7 m vs. 19.0 m vs. 12.7 m, P = 0.002; LCS: 25.4 m vs. 19.3 m vs. 14.7 m, P = 0.004) compared with patients with stable or worsened QoL. Furthermore, in patients with good QoL at baseline, the treatment of gefitinib couldn’t improve OS compared to placebo, whereas patients with low QoL experienced marginal significant improvement in OS (20.6 m vs 14.4, p = 0.051). Our study indicated that gefitinib could improve patients’ QoL, confirmed the prognostic value of QoL changes during treatment and implied patients with low QoL at baseline may be the potential population which will gain OS benefit from maintenance EGFR-TKI therapy.
Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies
Authors: Moilanen Anu-Maarit , Riikonen Reetta , Oksala Riikka , Ravanti Laura , Aho Eija , Wohlfahrt Gerd , Nykänen Pirjo S. , Törmäkangas Olli P. , Palvimo Jorma J. , Kallio Pekka J. 
Published: July 2015

AbstractActivation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR and several mechanisms have been proposed to explain the addiction. Known causes of CRPC include gene amplification and overexpression as well as point mutations of AR. We report here the pharmacological profile of ODM-201, a novel AR inhibitor that showed significant antitumor activity and a favorable safety profile in phase 1/2 studies in men with CRPC. ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509, inhibits testosterone-induced nuclear translocation of AR. Importantly, ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies, including the F876L mutation that confers resistance to enzalutamide and ARN-509. In addition, ODM-201 reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model. In contrast to other antiandrogens, ODM-201 shows negligible brain penetrance and does not increase serum testosterone levels in mice. In conclusion, ODM-201 is a potent AR inhibitor that overcomes resistance to AR-targeted therapies by antagonizing both overexpressed and mutated ARs. ODM-201 is currently in a phase 3 trial in CRPC.
The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients
Authors: He Miao , Fu Yingzi , Yan Yuanyuan , Xiao Qinghuan , Wu Huizhe , Yao Weifan , Zhao Haishan , Zhao Lin , Jiang Qian , Yu Zhaojin , Jin Feng , Mi Xiaoyi , Wang Enhua , Cui Zeshi , Fu Liwu , Chen Jianju , Wei Minjie 
Published: July 2015

BCSCs (breast cancer stem cells) have been shown to be resistant to chemotherapy. However, the mechanisms underlying BCSC-mediated chemoresistance remain poorly understood. The Hh (Hedgehog) pathway is important in the stemness maintenance of CSCs. Nonetheless, it is unknown whether the Hh pathway is involved in BCSC-mediated chemoresistance. In the present study, we cultured breast cancer MCF-7 cells in suspension in serum-free medium to obtain BCSC-enriched MCF-7 MS (MCF-7 mammosphere) cells. We showed that MCF-7 MS cells are sensitive to salinomycin, but not paclitaxel, distinct from parent MCF-7 cells. The expression of the critical components of Hh pathway, i.e. PTCH (Patched), SMO (Smoothened), Gli1 and Gli2, was significantly up-regulated in MCF-7 MS cells; salinomycin, but not paclitaxel, treatment caused a remarkable decrease in expression of those genes in MCF-7 MS cells, but not in MCF-7 cells. Salinomycin, but not paclitaxel, increased apoptosis, decreased the migration capacity of MCF-7 MS cells, accompanied by a decreased expression of c-Myc, Bcl-2 and Snail, the target genes of the Hh pathway. The salinomycin-induced cytotoxic effect could be blocked by Shh (Sonic Hedgehog)-mediated Hh signalling activation. Inhibition of the Hh pathway by cyclopamine could sensitize MCF-7 MS cells to paclitaxel. In addition, salinomycin, but not paclitaxel, significantly reduced the tumour growth, accompanied by decreased expression of PTCH, SMO, Gli1 and Gli2 in xenograft tumours. Furthermore, the expression of SMO and Gli1 was positively correlated with the expression of CD44+/CD24−, and the expression of SMO and Gli1 in CD44+/CD24− tissues was associated with a significantly shorter OS (overall survival) and DFS (disease-free survival) in breast cancer patients receiving chemotherapy.
Thin Versus Thick Description: Analyzing Representations of People and Their Life Worlds in the Literature of Communication Sciences and Disorders
Authors: Hengst Julie A. , Devanga Suma , Mosier Hillary 
Published: July 2015

Purpose
Evidence-based practice relies on clinicians to translate research evidence for individual clients. This study, the initial phase of a broader research project, examines the textual resources of such translations by analyzing how people with acquired cognitive-communication disorders (ACCD) and their life worlds have been represented in Communication Sciences and Disorders (CSD) research articles.

Method

Using textual analysis, we completed a categorical analysis of 6,059 articles published between 1936 and 2012, coding for genre, population, and any evidence of thick representations of people and their life worlds, and a discourse analysis of representations used in 56 ACCD research articles, identifying
thin
and
thick
representations in 4 domains (derived from the International Classification of Functioning, Disability, and Health) and across article sections.

Results
The categorical analysis identified a higher percentage of ACCD articles with some evidence of thick representation (30%) compared with all CSD articles (12%) sampled. However, discourse analysis of ACCD research articles found that thick representations were quite limited; 34/56 articles had thin representational profiles, 19/56 had mixed profiles, and 3/56 had thick profiles.

Conclusions
These findings document the dominance of thin representations in the CSD literature, which we suggest makes translational work more difficult. How clinicians translate such evidence will be addressed in the next research phase, an interview study of speech-language pathologists.
Pleural effusion detection system using wideband slot‐loaded loop antenna
Authors: Ahdi Rezaeieh S. , Abbosh A.M. , Zamani A. , Bialkowski K. 
Published: July 2015

Pleural effusion (PE) is the accumulation of fluids around the lungs due to various diseases, such as cancer, liver and heart failure. Given the fact that fluid provides a high contrast in terms of dielectric constant at microwave frequencies, a radar‐based microwave imaging system is proposed to utilise that change in properties for the early detection of PE. The system uses a wideband slot‐loaded loop antenna to scan the torso, a portable vector network analyser for signal generation and recording, and a laptop for signal processing and image formation using a frequency‐based imaging algorithm. The utilised antenna is designed to have a compact size (in wavelengths) of 0.23 × 0.23 that is one‐third the size of recent designs. By using proper slots in a conventional slot‐loaded loop and adding a staircase‐shaped patch to the loop's perimeter, the antenna achieves a fractional bandwidth of 50% (0.72–1.19 GHz), and a peak gain of 4.9 dBi. The practicality of the proposed system is successfully tested by detecting a small amount of fluid (3 mL) around the lungs of a realistic life‐size torso phantom.
Detecting small attractors of large Boolean networks by function‐reduction‐based strategy
Authors: Zheng Qiben , Shen Liangzhong , Shang Xuequn , Liu Wenbin 
Published: July 2015

Boolean networks (BNs) are widely used to model gene regulatory networks and to design therapeutic intervention strategies to affect the long‐term behaviour of systems. A central aim of Boolean‐network analysis is to find attractors that correspond to various cellular states, such as cell types or the stage of cell differentiation. This problem is NP‐hard and various algorithms have been used to tackle it with considerable success. The idea is that a singleton attractor corresponds to n consistent subsequences in the truth table. To find these subsequences, the authors gradually reduce the entire truth table of Boolean functions by extending a partial gene activity profile (GAP). Not only does this process delete inconsistent subsequences in truth tables, it also directly determines values for some nodes not extended, which means it can abandon the partial GAPs that cannot lead to an attractor as early as possible. The results of simulation show that the proposed algorithm can detect small attractors with length p = 4 in BNs of up to 200 nodes with average indegree K = 2.
Behandlung einer erwachsenen Patientin mit dolichofazialem Wachstum, skelettaler Klasse III und asymmetrischem Unterkiefer
Authors: Sánchez B. I. , Pérez-Varela J. C. 
Published: July 2015

ZusammenfassungIn diesem Fallbericht wird die Behandlung einer Patientin mit skelettaler Klasse III und asymmetrischem Unterkiefer vorgestellt. Die Patientin zeigte ein konkaves Gesichtprofil, das untere Gesichtsdrittel war vergrößert, die oberen Schneidezähne standen normal und die unteren retroklin.Um sämtliche Behandlungsziele sowie die ästhetische Verbesserung des Gesichtes zu erreichen, wäre hier ein kieferorthopädisch-chirurgisches Verfahren notwendig.Obwohl es sich dabei um die ideale Behandlungsoption handelt, verweigern Patienten häufig eine kombinierte kieferorthopädisch-chirurgische Therapie. In solchen Fällen sind kompensierende Behandlungsmaßnahmen erforderlich.Wir präsentieren hier einen Fall, in dem bei einer erwachsenen dolichofazialen Patientin mit skelettaler Klasse III und Asymmetrie des Unterkiefers eine ausschließlich kieferorthopädische kompensierende Behandlung mit einseitiger Extraktion von Zähnen durchgeführt wurde.
Anomalous behavior of water inside the SecY translocon
Authors: Capponi Sara , Heyden Matthias , Bondar Ana-Nicoleta , Tobias Douglas J. , White Stephen H. 
Published: July 2015

Significance
α-Helical membrane proteins are assembled cotranslationally into cell membranes with the aid of the heterotrimeric membrane-embedded translocon complex. The structures of several translocons reveal that the interior has an hourglass shape filled with water. Because nascent peptide chains emerging from the ribosome are thought to pass through the translocon during secretion or membrane insertion, the translocon is often referred to as a protein-conducting channel. We show by all-atom molecular-dynamics simulations that the water molecules within a translocon do not behave as in a bulk phase, which raises fundamental questions not only about the current conceptual model of translocon-assisted insertion of membrane proteins but also about the physical principles of partitioning of solutes between bulk and confined water.
Chicken heat shock protein HSPB1 increases and interacts with αB-crystallin in aged skeletal muscle
Authors: Ueda Shuji , Kokaji Yoshito , Simizu Shunsaku , Honda Kazuhisa , Yoshino Ken-ichi , Kamisoyama Hiroshi , Shirai Yasuhito , Yamanoue Minoru 
Published: July 2015

Abstract
International trading markets of meat require the animal’s age information to prevent cross-contamination of ineligible meat products. Individual livestock age is either evaluated from physiological features or verified by breeding history. However, it remains impossible to perform age verification on meat when a suspicion of error occurred in the importing country. To investigate an age-related protein in skeletal muscle of livestock, we compared protein expression among chicken pectoralis major of different ages. Results indicated that the level of expression of chicken HSPB1, one of the small heat shock proteins, was increased in aged muscles. On the other hand, other heat shock proteins, heat shock factors, and myosin heavy chain isoform did not change the expression levels in aged chicken muscle. In addition, we identified that αB-crystallin interacted with HSPB1 in aged chicken muscle. These results suggest that HSPB1 protein forms complexes with αB-crystallin in aged chicken muscle and suppose to become the candidate of age-related bio-marker for verifying the age of chicken meat.
Key comparison of liquid density standards
Authors: Buchner Christian , Zelenka Zoltan , Kajastie Heikki , Madec Tanguy , Wolf Henning , Vámossy Csilla , Lorefice Salvatore , Garberg Torgunn , Lenard Elżbieta , Spohr Isabel , Mares Gabriela , Spurný Robert , Lumbreras Angel , Medina Nieves , Akçadağ Ümit Y , Perkin Michael 
Published: July 2015

Hydrostatic density determination for liquids is mainly performed by laboratories to provide means for calibrating liquid density measuring instruments such as oscillation-type density meters. From 2002 to 2005 the CIPM key comparison CCM.D-K2 ‘comparison of liquid density standards’ was carried out piloted by the PTB. The aim was to compare the results of the density determination by the participating laboratories to support entries to the CMC tables in this sub-field. To provide further laboratories the possibility to support their entries to the CMC tables at the meeting of the EUROMET Working Group on Density in 2007 this comparison was agreed on.
BEV (Austria) organized the comparison supported by the PTB (Germany).
For the comparison samples of pentadecane, water, tetrachloroethylene and of an oil of high viscosity were measured in the temperature range from 5 °C to 60 °C at atmospheric pressure by hydrostatic weighing.
The measurements were completed in 2008. The reference values of the first reports based on the draft of the CCM.D-K2. After the official publication of the CCM.D-K2 the reference values were recalculated and the report was finalised in 2015.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
ERGC: an efficient referential genome compression algorithm
Authors: Saha Subrata , Rajasekaran Sanguthevar 
Published: July 2015

Abstract
Motivation: Genome sequencing has become faster and more affordable. Consequently, the number of available complete genomic sequences is increasing rapidly. As a result, the cost to store, process, analyze and transmit the data is becoming a bottleneck for research and future medical applications. So, the need for devising efficient data compression and data reduction techniques for biological sequencing data is growing by the day. Although there exists a number of standard data compression algorithms, they are not efficient in compressing biological data. These generic algorithms do not exploit some inherent properties of the sequencing data while compressing. To exploit statistical and information-theoretic properties of genomic sequences, we need specialized compression algorithms. Five different next-generation sequencing data compression problems have been identified and studied in the literature. We propose a novel algorithm for one of these problems known as reference-based genome compression.
Results: We have done extensive experiments using five real sequencing datasets. The results on real genomes show that our proposed algorithm is indeed competitive and performs better than the best known algorithms for this problem. It achieves compression ratios that are better than those of the currently best performing algorithms. The time to compress and decompress the whole genome is also very promising.
Availability and implementation: The implementations are freely available for non-commercial purposes. They can be downloaded from http://engr.uconn.edu/∼rajasek/ERGC.zip.
Contact: rajasek@engr.uconn.edu