bluuebunny/crossref_metadata_2025_split huggingface dataset:
Channel estimation errors impact on the sum rate maximisation in a JP‐CoMP transmission systems
Authors: Abdelkefi Fatma , Feki Souhaila , Mohamed Siala , Ferré Guillaume 
Published: July 2013

AbstractCooperation between multicell base stations (BSs) is a promising technique that has the potential to mitigate inter‐cell interference (ICI) and increase data rates without sacrificing additional frequency spectrum. Classical beamforming techniques have been used to eliminate the existing ICI and improve the sum rate of downlink cooperative multiple input multiple output transmission systems. However, a perfect knowledge of the channel state information at the transmitter is needed to perform adequate beamforming such as block diagonalisation or zero‐forcing preprocessing. In practice, this is not the case due to the presence of channel estimation errors.In this paper, we consider one particular scenario of the transmission coordination among multiple cell sites, namely the joint processing coordinated multipoint transmission scheme. A joint processing coordinated multipoint is composed of several BSs that cooperate to serve a set of mobile stations (MSs) and where both BSs and MSs are equipped with multiple antennas. In the context of this transmission scenario, we model the multicell cooperative system under the presence of channel estimation errors that are often neglected but that can significantly influence the obtained results. Furthermore, we consider a general framework where the distributed power from the BSs to the MSs is not constrained to be identical. We then propose a modified version of the classical block diagonalisation and zero‐forcing beamforming to efficiently mitigate the existing ICI. Finally, we evaluate the sum rate expression of the considered cooperative system, and we propose efficient alternatives to improve it without coupling the beamforming and the power control processes. Simulation results are given to support our claims. Copyright © 2013 John Wiley & Sons, Ltd.
A survey on energy awareness mechanisms in routing protocols for wireless sensor networks using optimization methods
Authors: Shamsan Saleh Ahmed M. , Ali Borhanuddin Mohd , Rasid Mohd Fadlee A. , Ismail Alyani 
Published: July 2013

ABSTRACTOver recent years, enormous amounts of research in wireless sensor networks (WSNs) have been conducted; this is because of its multifarious applications such as in environmental monitoring, object tracking, disaster management, manufacturing, monitoring and control. Nevertheless, optimising the energy consumption of sensor nodes (SNs) in WSNs and realising the anticipated quality of solutions supplied from them present considerable challenges. In WSNs, the sudden ‘death’ of critical nodes can cause an entire network to malfunction. This is usually caused by uneven depletion of battery power of the individual nodes. Therefore, this survey investigates the methods that aim to minimise usage of energy in SNs, especially during routing. This is because network activities start to be challenged when the first SN exhausts its battery. In addition, this paper introduces a comprehensive categorization of the energy‐aware protocols in WSNs. Thus, the motivation of this survey is to present some decentralised energy‐aware routing using optimization methods that is generic and applicable to most of WSN applications that require reduction of energy consumptions and extend a network's life time. Copyright © 2013 John Wiley & Sons, Ltd.
Identification of Grouped Rare and Common Variants via Penalized Logistic Regression
Authors: Ayers Kristin L. , Cordell Heather J. 
Published: July 2013

ABSTRACTIn spite of the success of genome‐wide association studies in finding many common variants associated with disease, these variants seem to explain only a small proportion of the estimated heritability. Data collection has turned toward exome and whole genome sequencing, but it is well known that single marker methods frequently used for common variants have low power to detect rare variants associated with disease, even with very large sample sizes. In response, a variety of methods have been developed that attempt to cluster rare variants so that they may gather strength from one another under the premise that there may be multiple causal variants within a gene. Most of these methods group variants by gene or proximity, and test one gene or marker window at a time. We propose a penalized regression method (PeRC) that analyzes all genes at once, allowing grouping of all (rare and common) variants within a gene, along with subgrouping of the rare variants, thus borrowing strength from both rare and common variants within the same gene. The method can incorporate either a burden‐based weighting of the rare variants or one in which the weights are data driven. In simulations, our method performs favorably when compared to many previously proposed approaches, including its predecessor, the sparse group lasso [Friedman et al., 2010].
An Exploratory Study of Maternal Depressive Symptoms and Infant's Social Skills in Korea: The Mediating Role of Mothers’ Social Interactions with their Infants
Authors: Choi Eunsil 
Published: July 2013

ABSTRACTThe purpose of this study is to examine the potential mediating role of mothers’ social interactions with their infants in the association between maternal depressive symptoms (MDSs) at three time points and infants’ social skills in Korea. Data were taken from 1,472 infants and mothers of the Public Study of Korean Children. Mothers completed the Kessler 6 to examine MDSs at three time points. Mothers also completed the Parenting Style Questionnaires to assess infants’ social skills. Correlational analyses revealed that mothers who had depressive symptons when infants were 4 months of age were less likely to be responsive and sensitive when mothers interacted with their infants. In addition, sensitive and responsive interactions with their infants were positively correlated with infants’ social skills. Structural equation model analyses showed that mothers’ responsive and sensitive interactions with their infants entirely mediated the association between MDSs at 4 months’ postpartum and infants’ social skills. The findings suggest that the mediating role of sensitive and responsive interactions with their infants in the association betweemn MDSs and infants’ social skills is potentially similar in Asian samples.
Modulation of apoptosis by caprine herpesvirus 1 infection in a neuronal cell line
Authors: Montagnaro Serena , Ciarcia Roberto , De Martinis Claudio , Pacilio Carmen , Sasso Simona , Puzio Maria Valeria , De Angelis Morena , Pagnini Ugo , Boffo Silvia , Kenez Ivanna , Iovane Giuseppe , Giordano Antonio 
Published: July 2013

ABSTRACTCaprine herpesvirus type 1 (CpHV‐1), like other members of the alpha subfamily of herpesviruses, establishes latent infections in trigeminal ganglion neurons. Our groups previously demonstrated that CpHV‐1 induces apoptosis in goat peripheral blood mononuclear cells and in an epithelial bovine cell line, but the ability of CpHV‐1 to induce apoptosis in neuronal cells remains unexplored. In this report, the susceptibility of Neuro 2A cells to infection by CpHV‐1 was examined. Following infection of cultured cells with CpHV‐1, expression of cell death genes was evaluated using real‐time PCR and Western blot assays. Analysis of virus‐infected cells revealed activation of caspase‐8, a marker for the extrinsic pathway of apoptosis, and caspase‐9, a marker for the intrinsic pathway of apoptosis at 12 and 24 h post‐infection. Significant increase in the levels of cleaved caspase‐3 was also observed at the acme of cytopathic effect at 24 h post‐infection. In particular, at 3 and 6 h post‐infection, several proapototic genes were under‐expressed. At 12 h post‐infection several proapototic genes such as caspases, TNF, Cd70, and Traf1 were over expressed while Bcl2a1a, Fadd, and TNF genes were underexpressed. In conclusion, the simultaneous activation of caspase‐8 and caspase‐9 suggests that CpHV‐1 can trigger the death‐receptor pathway and the mitochondrial pathway separately and in parallel. Our findings are significant because this is the first published study showing the effect of CpHV‐1 infection in neuronal cells in terms of gene expression and apoptosis modulation. J. Cell. Biochem. 114: 2809–2822, 2013. © 2013 Wiley Periodicals, Inc.
Safety, Pharmacokinetic, Immunogenicity, and Pharmacodynamic Responses in Healthy Volunteers Following a Single Intravenous Injection of Purified Staphylococcal Protein A
Authors: Ballow Charles , Leh Anissa , Slentz‐Kesler Kimberly , Yan Jim , Haughey David , Bernton Edward 
Published: July 2013

AbstractA single‐dose study was conducted to characterize the safety, pharmacokinetic, immunogenicity, and pharmacodynamic activity of highly purified Staphylococcal protein A (SPA), a native bacterial protein with immune‐modulatory activity. Twenty healthy adults received a single intravenous dose of either 0.3 µg/kg (n = 8) or 0.45 µg/kg (n = 8) of SPA or placebo (n = 4). Changes in C‐reactive protein and neopterin were used as markers of immune activation. All treatment‐related AEs were of mild severity. Twelve of 16 active‐dosed subjects developed detectable anti‐protein A antibodies after dosing. These subjects had notably more rapid plasma clearance of SPA even prior to development of detectable titers. A transient post‐dose decrease in circulating lymphocytes was observed as a notable pharmacodynamic effect, but was not correlated with plasma clearance or AUC. In peripheral blood mononuclear cells, SPA dosing increased transcription of multiple genes regulated by type‐1 interferons, and up‐regulation of several of these genes correlated with the degree of lymphopenia seen 24 hours after dosing. This study demonstrates the safety and tolerability of small intravenous doses of SPA and delineates acute and transient pharmacodynamic effects not previously reported.
Evaluation of Hepatic Impairment Dosing Recommendations in FDA‐Approved Product Labels
Authors: Chang Yang , Burckart Gilbert J. , Lesko Lawrence J. , Dowling Thomas C. 
Published: July 2013

AbstractPharmacokinetic (PK) studies in patients with liver disease are an important clinical pharmacology component of drug development. In 2003, FDA released the guidance for industry on “Pharmacokinetics in Patients with Impaired Hepatic Function,” which provides recommendations to sponsors on study design, data analysis, and impact on dosing and labeling. We evaluated the quality and consistency of hepatic dosing recommendations, and compared contemporary clinical practice of dosing in patients with impaired hepatic function with product labels. All new molecular entities (NME) and labels approved by the FDA during the period of January 2004 to December 2011 were reviewed. The fraction of the dose hepatically eliminated, quality of hepatic impairment PK studies reported, and any dose recommendations provided in the label and in a tertiary clinical reference (Micromedex) were reviewed. Out of 157 NMEs, 67 met the criteria for evaluation of dosing in hepatic disease. Problem areas were identified related to the lack of specific hepatic metabolism information in 90% of FDA‐approved labels, inconsistent terminology, and “use with caution in liver disease” in 27% of NME. Updating the FDA guidance on PK studies in patients with impaired hepatic function could provide a standardized approach to improve the clinical usefulness of this dosing information for practitioners.
Statistical shape modeling of cam femoroacetabular impingement
Authors: Harris Michael D. , Datar Manasi , Whitaker Ross T. , Jurrus Elizabeth R. , Peters Christopher L. , Anderson Andrew E. 
Published: July 2013

ABSTRACTStatistical shape modeling (SSM) was used to quantify 3D variation and morphologic differences between femurs with and without cam femoroacetabular impingement (FAI). 3D surfaces were generated from CT scans of femurs from 41 controls and 30 cam FAI patients. SSM correspondence particles were optimally positioned on each surface using a gradient descent energy function. Mean shapes for groups were defined. Morphological differences between group mean shapes and between the control mean and individual patients were calculated. Principal component analysis described anatomical variation. Among all femurs, the first six modes (or principal components) captured significant variations, which comprised 84% of cumulative variation. The first two modes, which described trochanteric height and femoral neck width, were significantly different between groups. The mean cam femur shape protruded above the control mean by a maximum of 3.3 mm with sustained protrusions of 2.5–3.0 mm along the anterolateral head‐neck junction/distal anterior neck. SSM described variations in femoral morphology that corresponded well with areas prone to damage. Shape variation described by the first two modes may facilitate objective characterization of cam FAI deformities; variation beyond may be inherent population variance. SSM could characterize disease severity and guide surgical resection of bone. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1620–1626, 2013
Postirradiation otitis media with effusion in nasopharyngeal carcinoma patients treated by intensity‐modulated radiotherapy
Authors: Hsin Chung‐Han , Chen Tsai‐Hsin , Liang Kai‐Li , Tseng Hsien‐Chun , Liu Wen‐Shan 
Published: July 2013

Objectives/HypothesisPostirradiation otitis media with effusion (OME) is a common adverse otologic effect in nasopharyngeal carcinoma (NPC) patients treated by radiotherapy. The purpose of this study was to determine the long‐term incidence of postirradiation OME in NPC patients following intensity‐modulated radiotherapy (IMRT) and to evaluate the potential factors associated with the development of this otologic complication.Study DesignRetrospective observational study.MethodsA retrospective review of NPC patients treated by IMRT between January 2002 and June 2008 was conducted. Otologic complications were regularly evaluated during follow‐up. Presence of OME was detected by findings of otoscopic exam, pure‐tone audiometry, impedance audiometry, and tympanocentesis. Incidence of postirradiation OME and relevant factors were analyzed.ResultsA total of 105 patients (210 ears) were enrolled in the study. There were 34 patients (32.4%) with unilateral or bilateral postirradiation OME 3 years or more following radiotherapy. There was no correlation between the complication and the stage of primary tumor. The presence of pretreatment OME, however, was significantly associated with the development of postirradiation OME. Although there was no significant relationship between the radiation dose and post‐treatment OME, the link with radiation toxicity was demonstrated by the finding that 28% of postirradiation OME developed in the ears contralateral to the side of primary nasopharyngeal tumor.ConclusionsPostirradiation OME remains a common late toxicity in NPC patients treated by modern radiotherapy. Pretreatment injuries by the tumor and radiation‐induced damages to the eustachian tube both play a major role in the development of the otologic complication.Level of EvidenceLevel of Evidence: 3b (nonconsecutive cohort study). Laryngoscope, 123:2148–2153, 2013
Results of myringoplasty operations in active and inactive ears in adults
Authors: Mills Robert , Thiel Gundula , Mills Nadtaya 
Published: July 2013

Objectives/HypothesisTo determine whether the presence of aural discharge at the time of surgery adversely affects the success rate of myringoplasty operations.Study DesignCase series comparing the success rate of surgery in active and inactive ears.MethodsData pertaining to 268 operations involving repair of the tympanic membrane without ossiculoplasty carried out in Edinburgh, United Kingdom, between 1999 and 2009 by one senior surgeon and trainees working under his supervision were collected prospectively. Other factors that might potentially influence the outcome of the surgery were investigated using logistical regression analysis. The main outcome measure was number of patients with an intact tympanic membrane 6 months after surgery in the two groups (active and inactive).ResultsOf the 268 operations carried out, 203 were successful, with an intact tympanic membrane, 6 months postoperatively, 43 had persistent perforations, and 22 patients were lost to follow‐up before 6 months. The success rates for closure of the perforation at 6 months after surgery were 83% for inactive and 82% for active ears (P = .9).ConclusionsThere is no clinically significant difference in the success rate for myringoplasty in patients whose ears are active or inactive at the time of surgery.Level of Evidence4. Laryngoscope, 123:2245–2249, 2013
Sudden sensorineural hearing loss is correlated with an increased risk of acute myocardial infarction: A population‐based cohort study
Authors: Lin Charlene , Lin Shih‐Wei , Lin Yung‐Song , Weng Shih‐Feng , Lee Tsung‐Ming 
Published: July 2013

Objectives/HypothesisPrevious studies have indicated that hypercholesterolemia and a high burden of cardiovascular risk factors are associated with the development of sudden sensorineural hearing loss (SSHL). The purpose of this study was to test the hypothesis that SSHL is a risk factor for the development of myocardial infarction (MI).Study DesignA retrospective cohort study.MethodsUsing the Taiwan Longitudinal Health Insurance Database, we compared patients diagnosed with SSHL between January 1, 2001, and December 31, 2006, (N = 44,830) with age‐matched controls (1:1) (N = 44,830). We followed up on each patient until the end of 2009 to evaluate the incidence of MI for a minimum period of 3 years after their initial SSHL diagnosis.ResultsWe found that after adjusting for potential confounds with an adjusted hazard ratio (HR) of 1.254 (95% confidence interval, 1.092–1.440, P < 0.05), patients with SSHL were more likely to suffer MI than the control population. When stratified by patient age, the incidence of MI was 1.62‐fold and 1.28‐fold higher for SSHL‐diagnosed patients aged between 50 and 64 years and those aged ≥ 65 years (P = 0.0064 and P = 0.0001), respectively, than in the non‐SSHL group.ConclusionsSSHL may confer an independent risk of MI. This observation may prompt the early detection and timely treatment of patients at a high risk of MI.Level of Evidence2B. Laryngoscope, 123:2254–2258, 2013
Protein carbonylation as a major hallmark of oxidative damage: Update of analytical strategies
Authors: Fedorova Maria , Bollineni Ravi Chand , Hoffmann Ralf 
Published: July 2013

AbstractProtein carbonylation, one of the most harmful irreversible oxidative protein modifications, is considered as a major hallmark of oxidative stress‐related disorders. Protein carbonyl measurements are often performed to assess the extent of oxidative stress in the context of cellular damage, aging and several age‐related disorders. A wide variety of analytical techniques are available to detect and quantify protein‐bound carbonyls generated by metal‐catalyzed oxidation, lipid peroxidation or glycation/glycoxidation. Here we review current analytical approaches for protein carbonyl detection with a special focus on mass spectrometry‐based techniques. The utility of several carbonyl‐derivatization reagents, enrichment protocols and especially advanced mass spectrometry techniques are compared and discussed in detail. Furthermore, the mechanisms and biology of protein carbonylation are summarized based on recent high‐throughput proteomics data. © 2013 Wiley Periodicals, Inc. Mass Spec Rev 33: 79–97, 2014.
A new genome scan for primary nonsyndromic vesicoureteric reflux emphasizes high genetic heterogeneity and shows linkage and association with various genes already implicated in urinary tract development
Authors: Darlow J. M. , Dobson M. G. , Darlay R. , Molony C. M. , Hunziker M. , Green A. J. , Cordell H. J. , Puri P. , Barton D. E. 
Published: July 2013

AbstractPrimary vesicoureteric reflux (VUR), the retrograde flow of urine from the bladder toward the kidneys, results from a developmental anomaly of the vesicoureteric valve mechanism, and is often associated with other urinary tract anomalies. It is the most common urological problem in children, with an estimated prevalence of 1–2%, and is a major cause of hypertension in childhood and of renal failure in childhood or adult life. We present the results of a genetic linkage and association scan using 900,000 markers. Our linkage results show a large number of suggestive linkage peaks, with different results in two groups of families, suggesting that VUR is even more genetically heterogeneous than previously imagined. The only marker achieving P < 0.02 for linkage in both groups of families is 270 kb from EMX2. In three sibships, we found recessive linkage to KHDRBS3, previously reported in a Somali family. In another family we discovered sex‐reversal associated with VUR, implicating PRKX, for which there was weak support for dominant linkage in the overall data set. Several other candidate genes are suggested by our linkage or association results, and four of our linkage peaks are within copy‐number variants recently found to be associated with renal hypodysplasia. Undoubtedly there are many genes related to VUR. Our study gives support to some loci suggested by earlier studies as well as suggesting new ones, and provides numerous indications for further investigations.
FSH modulates the expression of inhibin‐alpha and the secretion of inhibins via orphan nuclear receptor NUR77 in ovarian granulosa cells
Authors: He Qin‐Yuan , Ding Li‐Jun , Sun Hai‐Xiang , Yu Bin , Dai An‐Yi , Zhang Ning‐Yuan , Wang Bin , Yan Gui‐Jun , Xu Pei‐Zhen , Hu Ya‐Li 
Published: July 2013

SUMMARYIt has been previously reported that follicle‐stimulating hormone (FSH) regulates the expression of inhibin‐alpha in human granulosa cells, but the precise molecular pathway remains unknown. In the present study, we investigated the role of the orphan nuclear receptor, NUR77, in both the transcriptional regulation of the inhibin α‐subunit gene and the secretion of inhibins. Our results showed that in a human granulosa cell tumor‐derived cell line (KGN) and in human granulosa‐lutein cells (hGL), FSH induced the expression of NUR77 and inhibin‐alpha, although inhibin‐alpha expression did not increased following FSH treatment if NUR77 was knocked down. Furthermore, simply overexpressing or reducing NUR77 levels affected inhibin‐alpha expression, while NUR77 overexpression improved the secretion of inhibin A and B from human granulosa cells. In addition, chromatin immunoprecipitation–PCR, avidin–biotin‐conjugated DNA precipitation, and luciferase reporter assays confirmed that NUR77 directly regulated the transcription of the inhibin‐alpha gene through the specific NGFI‐B response element located within its promoter. In the ovarian granulosa cells of the Nur77 knockout mice, the mRNA levels of inhibin‐alpha were decreased relative to wild‐type mice. These data indicate a role of NUR77 in the regulation of inhibin‐alpha in ovarian granulosa cells. Mol. Reprod. Dev. 80: 734–743, 2013. © 2013 Wiley Periodicals, Inc.