bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Vaginal Cerclage Assisted Laparoscopic Cervico-Sacropexy Technique for Uterovaginal Prolapse
Authors: Aydın Serdar , Çekiç Sebile Güler 
Published: August 2024

Aim Laparoscopic hysteropexy is a complicated procedure that requires specialized surgical skills, including precise dissection and suturing. The aim is to describe the technical considerations for performing a new, feasible, and minimally invasive technique to correct apical and concurrent apical and anterior vaginal wall defects. Method A retrospective analysis was conducted on 70 consecutive women who underwent surgery for stage ≥3 uterovaginal prolapse. As a part of the technique, an anterior 2-cm long transverse incision was made at the anterior cervicovaginal junction, and the bladder was dissected through blunt and sharp dissection to the level of the isthmus. A posterior colpotomy was performed. A polypropylene tape was inserted into the cervical connective tissue, and the free arms of the tape were inserted into the peritoneum via the posterior colpotomy. Two arms of the tape were passed from the tunnel parallel and medial to a right sacrouterine fold, then fixed to the anterior longitudinal ligament via the laparoscopic route. Results The tape can be inserted into the cervix in a median of 15 min, and the laparoscopy procedure can be completed in 24 min. No mesh erosion or long-term complications occurred. At a 1-year control, there were no cases of recurrence. Conclusions This novel cervico-sacrocolpopexy technique is a feasible and safe, minimally invasive way to correct apical or multicompartment defects, with a short operation time and an anatomical result that mimics the normal sacrouterine ligament.
Electronic Glycemic Management System Improved Glycemic Control and Reduced Complications in Patients With Diabetes Undergoing Coronary Artery Bypass Surgery: A Randomized Controlled Trial
Authors: Câmara de Souza Alexandre Barbosa , Toyoshima Marcos Tadashi Kakitani , Cukier Priscilla , Lottenberg Simão Augusto , Bolta Paula Mathias Paulino , Lima Eduardo Gomes , Serrano Júnior Carlos Vicente , Nery Marcia 
Published: August 2024

Background: In-hospital hyperglycemia poses significant risks for patients with diabetes mellitus undergoing coronary artery bypass graft (CABG) surgery. Electronic glycemic management systems (eGMSs) like InsulinAPP offer promise in standardizing and improving glycemic control (GC) in these settings. This study evaluated the efficacy of the InsulinAPP protocol in optimizing GC and reducing adverse outcomes post-CABG. Methods: This prospective, randomized, open-label study was conducted with 100 adult type 2 diabetes mellitus (T2DM) patients post-CABG surgery, who were randomized into two groups: conventional care (gCONV) and eGMS protocol (gAPP). The gAPP used InsulinAPP for insulin therapy management, whereas the gCONV received standard clinical care. The primary outcome was a composite of hospital-acquired infections, renal function deterioration, and symptomatic atrial arrhythmia. Secondary outcomes included GC, hypoglycemia incidence, hospital stay length, and costs. Results: The gAPP achieved lower mean glucose levels (167.2 ± 42.5 mg/dL vs 188.7 ± 54.4 mg/dL; P = .040) and fewer patients-day with BG above 180 mg/dL (51.3% vs 74.8%, P = .011). The gAPP received an insulin regimen that included more prandial bolus and correction insulin (either bolus-correction or basal-bolus regimens) than the gCONV (90.3% vs 16.7%). The primary composite outcome occurred in 16% of gAPP patients compared with 58% in gCONV ( P < .010). Hypoglycemia incidence was lower in the gAPP (4% vs 16%, P = .046). The gAPP protocol also resulted in shorter hospital stays and reduced costs. Conclusions: The InsulinAPP protocol effectively optimizes GC and reduces adverse outcomes in T2DM patients’ post-CABG surgery, offering a cost-effective solution for inpatient diabetes management.
SH003 Induces DR5-Mediated Caspase-Dependent Apoptosis of NSCLC Through Inhibition of AKT Survival Pathway
Authors: Kim Ji Hye , Kang Sooyeon , Lee Gyu-Ri , Ko Seong-Gyu 
Published: August 2024

Background Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is well known to selectively induce apoptotic cell death in cancer cells, not in normal cells, with death receptors (DRs)—DR4 and DR5. In consequence of this specialty, this cytokine and its receptors are considered for candidates of target therapy in clinic. SH003, a new traditional medicine-based polyherbal preparation, consists of Astragalus membranaceus (Am), Angelica gigas (Ag) and Trichosanthes kirilowii Maximowicz (Tk). In this study, we investigated whether SH003 can induce apoptosis through DRs in non-small-cell lung cancer (NSCLC) cells. Methods Cell proliferation and cytotoxicity were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), clonogenic assay, and, trypan blue exclusion staining, protein expression by western blot analysis, and apoptosis by fluorescence-activated cell sorting analysis. Results We found that SH003-induced apoptosis in NSCLC cells through several mechanisms. First of all, MTT and colony formation assay confirmed the growth-inhibitory effect of SH003 in H460 cells. Second, SH003 upregulated the expression of DR4 and DR5. Third, it activated caspase-8, caspase-7, and caspase-3 cascades, which are essential for DR-mediated extrinsic apoptosis. The effect of SH003-induced apoptosis was significantly abolished by inhibition of caspases enzymes. And also, SH003 cleaved caspse-9. Fourth, SH003 reduced AKT kinase phosphorylation, and overexpression of AKT abrogated the caspase-dependent apoptosis by SH003. Fifth, SH003 inactivated ERK, but, constitutive ERK expression did not completely reduce SH003-mediated growth inhibition and apoptosis. Conclusions SH003 potentiates caspase-dependent apoptosis of NSCLC through the upregulation of DRs, activation of caspase cascades and downregulation of AKT cell survival pathways.
Chondrocyte Response to Fresh Autologous Conditioned Serum Versus Freeze-Dried Allogenic Conditioned Serum
Authors: Credille Kevin , Elias Tristan J. , Allahabadi Sachin , Wang Zachary , Hakimiyan Arnavaz , Chubinskaya Susan , Cole Brian J. , Frisbie David , Yanke Adam B. 
Published: August 2024

Objective To investigate the cytokine release profile and histological response of human cartilage after exposure to autologous conditioned serum (ACS) and freeze-dried allogenic conditioned serum (FD-CS). Design Cartilage explants were collected from 6 patients undergoing total knee arthroplasty. ACS and FD-CS were created from patient serum samples. Cartilage samples were divided into 6 groups: (1) untreated control, (2) ACS, (3) FD-CS, (4) untreated interleukin (IL)-1β (5 ng/ml), (5) IL-1β + ACS, and (6) IL-1β + FD-CS. After 12 days, cartilage samples were analyzed with glycosaminoglycan (GAG) concentration normalized to wet weight while comparing cytokine concentrations, and histological scoring. Results There was a significant decrease in pathology scoring for ACS ( P = 0.0368) and FD-CS ( P = 0.0368) in the IL-1β injury groups compared with the untreated IL-1β insult group. ACS and FD-CS significantly mitigate the IL-1β induced increase in basic fibroblast growth factor (bFGF) ( P = 0.0009 and P = 0.0002, respectively). FD-CS showed a significant decrease in IL-1β concentration in the presence of IL-1β insult compared with the untreated IL-1β group ( P < 0.0001). ACS-treated samples had significantly higher concentration of tumor necrosis factor (TNF)-α independent of IL-1β when compared with samples not treated with biologics ( P = 0.0053). Conclusions Explanted osteoarthritic cartilage responds favorably and equivalently to treatment with ACS and FD-CS from a histological perspective. Both ACS and FD-CS were able to mitigate the IL-1β-induced increases in bFGF and FD-CS lowered IL-1β concentration while increasing interleukin-1 receptor antagonist (IL-1Ra) concentration. Although the cytokine profile of cartilage tissue explants treated with FD-CS appears to be different than that of ACS, this difference does not seem to affect biologic activity of FD-CS.
Association of the dietary inflammatory index with sarcopenic obesity and frailty in older adults
Authors: Jung Sukyoung , Lee Yunhwan , Kim Kirang , Park Sohyun 
Published: August 2024

Abstract
Objectives
This study examined whether a higher dietary inflammatory index (DII®) is associated with the risk of sarcopenic obesity (SO) and frailty among Korean older adults.

Methods
A total of 950 participants aged 70–84 years, who completed the baseline nutrition survey of the Korean Frailty and Aging Cohort Study, were included in the analysis. The DII, quantifying the dietary inflammatory potential, was calculated using 23 foods and nutrients as assessed by a 24-h dietary recall. SO was defined as the coexistence of sarcopenia (dual-energy X-ray absorptiometry-measured appendicular skeletal muscle mass index of < 7.0 for males; <5.4 for females) and abdominal obesity (waist circumference of ≥ 90 cm for males; ≥85 cm for females). Frailty status was assessed using the Fried frailty index (range, 0–5), a simple tool for defining frailty that consists of three or more of five frailty items. Multinomial logistic regression models were used to estimate odds ratios (ORs) with 95% confidence intervals (CIs), adjusting for confounders.

Results
The prevalence of SO and frailty was 9.8% and 10.8%, respectively. The DII was significantly higher in the frail group (2.7) compared to the robust and SO groups (2.0 vs. 1.8) (P < 0.001). Among nutrients and foods included in the DII, the frail group exhibited lower vitamin E, niacin, vitamin B6, energy, and protein intakes than the robust and SO groups. Multivariable-adjusted OR (95% CI) for frailty versus robust (comparing DII tertile 3 to tertile 1) was 2.3 (1.1–4.8; P-trend = 0.02). However, no significant association was observed between the DII and SO (OR, 1.1; 95% CI, 0.5–2.1; P-trend = 0.6).

Conclusions
A higher DII score was associated with increased odds of frailty but not with SO in Korean older adults, suggesting that proinflammatory diets have a greater impact on frailty than that on SO in the older population.
Children’s screen time and psychosocial symptoms at 5 years of age – the role of parental factors
Authors: Niiranen Janette , Kiviruusu Olli , Vornanen Riitta , Kylliäinen Anneli , Saarenpää-Heikkilä Outi , Paavonen E. Juulia 
Published: August 2024

Abstract
Background and objectives
Electronic media (e-media) has become a universal part of young children’s daily lives. Previous studies have found an association between increased screen time and children’s psychosocial symptoms. We investigated whether parents’ psychological distress and parenting style dimensions explain the association between children’s screen time and psychosocial symptoms. Moreover, we investigated whether parents’ mental well-being and parenting style dimensions moderate this association.

Methods
We used data from the Finnish CHILD-SLEEP birth cohort study. Parents and the child were assessed when the child was 5 years old (N = 671). The measure of screen time included program viewing from TV and other devices. Child’s psychosocial problems and parents’ depression, stress and parenting style dimensions were assessed by self-reports.

Results
A high level of screen time in children was associated with attention and concentration difficulties, hyperactivity and impulsivity symptoms as well as internalizing and externalizing symptoms among 5-year-olds. For the most part, the associations remained significant despite controlling for parents’ mental health, parenting style dimensions and multiple background factors, especially associations relating to attention and concentration difficulties and hyperactivity symptoms were robust. Maternal stress and depression moderated the association between children’s screen time and psychosocial symptoms, indicating a more pronounced association among stressed or depressed mothers.

Conclusion
There is an independent association between children’s screen time and psychosocial symptoms which is especially pronounced among those children whose mothers had poorer mental well-being. In clinical practice, the length of screen time should be inquired already at a young age and parents should be offered guidance to reduce the possible ill effects of excessive screen time, as well as help with their own mental health problems.
Impact of virtual reality on peri-interventional pain, anxiety and distress in a pediatric oncology outpatient clinic: a randomized controlled trial
Authors: Reitze Alicia , Voigt Marie , Klawonn Frank , Dusch Martin , Grigull Lorenz , Mücke Urs 
Published: August 2024

Abstract
Purpose
Pain and anxiety-inducing interventions have a major impact on pediatric patients. Pain reduction by virtual reality (VR) during port and vein punctures is well studied. This study investigates peri-interventional reduction of pain, anxiety and distress using VR compared to the standard of care (SOC) in a pediatric oncology outpatient clinic.

Methods
In a randomized, controlled cross-over design, patients aged 6–18 years experience potentially painful interventions accompanied by VR. Observational instruments include NRS, FPS-r, BAADS, mYPAS-SF, PedsQL and SSKJ3-8R. All patients undergo two observations: SOC (A) and VR (B) in a randomized order. In addition, parents and staff are interviewed. Specific conditions for VR in an outpatient clinic setting derived from interprofessional focus group discussion are being explored.

Results
Between July 2021 and December 2022 57 eligible patients were included and randomized to the orders A/B (n = 28) and B/A (n = 29). Thirty-eight patients completed both observations. Characteristics in both groups did not differ significantly. More than half of the patients had no previous experience with VR, 5% decided to discontinue VR prematurely. Peri-interventional pain, anxiety and distress were significantly reduced by VR compared with SOC. 71% of patients and 76% of parents perceived punctures with VR to be more relaxed than previous ones. 95% of patients perceived fun with VR goggles. Detailed questionnaires on individual stress and anxiety were returned from 26 of 38 patients. Focus group discussion with staff yielded evidence for successful implementation of VR in an outpatient clinic.

Conclusions
The present study shows that VR can be used for peri-interventional reduction of pain, anxiety, and distress in the special environment of a pediatric outpatient clinic. Specific conditions must be met for successful implementation. Further studies are needed to identify particularly susceptible patients and to illuminate alternatives for distraction that are feasible to implement with limited resources.

Trial registration number
(ClinicalTrials.gov ID): NCT06235723; 01/02/2024; retrospectively registered. This study adheres to the standard checklist of CONSORT guidelines.
Patient with Herlyn–Werner–Wunderlich syndrome and endometriosis achieves successful full-term pregnancy (40 weeks and 6 days): a case report
Authors: Oliveira Juliana Vieira Queiroz Almeida , Philip Chris Elizabeth , Pereira Thayná Andreza Ribeiro , Garcia Gabriela Martins Perez , Villamil Quésia Tamara Mirante Ferreira 
Published: August 2024

Abstract
Introduction
Herlyn–Werner–Wunderlich syndrome , a rare Müllerian ducts congenital disease, is characterized by a diphtheritic uterus, blind hemivagina, and ipsilateral renal agenesis. Diagnosis is at young age by ultrasound and magnetic resonance imaging, and the prognosis is good. Usually, complications evolve endometriosis and secondary pelvic inflammation.

Case report
A 40-year-old female patient, Brazilian, white, primigravida, diagnosed at 30 years with a didelphic uterus on ultrasound, and 4 years later, with a left ovarian endometrioma, multiple ovarian cysts, and left renal agenesis on magnetic resonance imaging. Subsequently, due to dyspareunia and a feeling of swelling, the patient underwent transvaginal ultrasound with bowel preparation, and a hematocolpos was found and Herlyn–Werner–Wunderlich syndrome was suspected; 10 years after the diagnosis she had a planned pregnancy. She presented frequent contractions following the 15th week of pregnancy and fortunately there were no complications or premature labor. Labor was inducted at 40 weeks and 6 days without progress and a cesarean section was indicated and performed without complications. Herlyn–Werner–Wunderlich syndrome often goes unnoticed, leading to inadequate treatment. Individuals with Herlyn–Werner–Wunderlich syndrome commonly face fertility issues, such as high miscarriage rate (21–33%), and obstetric complications, such as spontaneous abortions (40% risk), intrauterine growth restriction, postpartum hemorrhage, increased fetal mortality, preterm delivery (21–29%), and elevated rates of cesarean sections. In addition, there is higher susceptibility of developing endometriosis, especially with hemivaginal obstruction, and pelvic adhesions.

Conclusion
Early diagnosis enables timely treatment and, consequently, fewer complications. Still, when these factors are absent, vaginal birth may still be possible. The true prevalence and incidence of complications related to Herlyn–Werner–Wunderlich syndrome are still unknown.
Strategi Integrated Marketing Communication Mossa Coffee untuk Meningkatkan Brand Awareness
Authors: Luturmas Natan , Vanel Zon , Huwae George Nicholas 
Published: August 2024

Dalam era persaingan bisnis yang semakin ketat dan munculnya berbagai coffee shop di Indonesia Mossa Coffee diharapkan mampu bersaing dengan kompetitor lainnya. Namun, untuk bertahan dan sukses dalam pasar yang kompetitif ini, Mossa Coffee perlu mengembangkan Brand Awareness yang kuat dan berkelanjutan. Penelitian ini bertujuan untuk menginvestigasi dan menganalisis efektifitas strategi Integrated Marketing Communication (IMC) dalam meningkatkan Brand Awareness Mossa Coffee. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif. Data akan dikumpulkan melalui wawancara mendalam, dokumentasi, dan survey terhadap masyarakat yang datang mengunjungi Mossa Coffee. Data akan dianalisis secara deskriptif untuk mengidentifikasi praktik terbaik dan hambatan yang dihadapi oleh Mossa Coffee dalam upaya meningkatkan Brand Awareness-nya. Hasil dari penelitian ini diharapkan akan memberi wawasan mendalam tentang bagaimana strategi IMC diterapkan dan memengaruhi Brand Awareness Mossa Coffee. Penelitian ini akan membantu menggambarkan praktik dan tantangan yang dihadapi oleh Mossa Coffee dalam upaya membangun Brand Awareness yang kuat. Temuan penelitian ini memiliki potensi untuk menjadi panduan bagi pemilik Mossaa Coffee dan praktisi pemasaran dalam memperbaiki strategi mereka.
RANCANG BANGUN ALAT PEMBERI MAKAN KUCING TERJADWAL MENGGUNAKAN MODUL RTC BERBASIS ARDUINO
Authors: Ramadhan Nova , Badarudin Rohjai 
Published: August 2024

Abstrak. Penelitian ini untuk perancangan dan mengembangkan perangkat pemberi pakan kucing otomatis terjadwal berbasis Arduino Uno yang menggunakan modul RTC untuk mengatur waktu. Alat ini dilengkapi dengan motor servo sebagai mekanisme penggerak, LCD I2C untuk menampilkan informasi, LED sebagai lampu indikator, dan enam tombol push button yang masing-masing berfungsi untuk mengoperasikan alat secara manual, mengatur jam dan menit, serta mengatur dan menyetel waktu pemberian pakan secara terjadwal. Metode penelitian meliputi perancangan perangkat keras dan perangkat lunak, integrasi komponen, serta pengujian fungsionalitas alat. Hasil penelitian menunjukkan bahwa alat ini mampu memberikan pakan kucing dengan otomatis dalam tiga jadwal yang sudah ditetapkan dengan akurasi yang tinggi. Penggunaan modul RTC memastikan ketepatan waktu, sementara Arduino Uno memudahkan proses pemrograman dan kontrol alat. Kesimpulan dari penelitian ini adalah bahwa alat pemberi pakan kucing otomatis ini dapat membantu pemilik hewan peliharaan dalam mengatur pemberian pakan secara tepat waktu dan efisien, serta dapat menjadi solusi praktis bagi pemilik yang memiliki keterbatasan waktu untuk memberi makan secara manual. Pentingnya hasil penelitian ini terletak pada peningkatan kenyamanan dan kesejahteraan hewan peliharaan melalui otomatisasi proses pemberian pakan.
The Challenges of Artificial Intelligence (AI) in journalism in the Kurdistan region of Iraq
Authors:   Department of Media Technique, Technical College of Administration, Sulaimani Polytechnic University, Sulaymaneyah, Kurdistan region, Iraq, Rauf Aziz Arkan , Abdulqadir Mohammed Shakar ,   Department of Media Technique, Technical College of Administration, Sulaimani Polytechnic University, Sulaymaneyah, Kurdistan region, Iraq
Published: August 2024

ئامانجى ئەم توێژینەوەیە ئەوەیە کە چەمکى زیرەکى دەستکرد بناسێنێت و لەگەڵ خستنەرووى دەرفەت و ئاڵنگارییەکانى بەردەم زیرەکى دەستکرد لە ژینگەى پراکتیکى ڕۆژنامەوانی لە هەرێمى کوردستاندا.	بایەخى ئەم توێژینەوە لەوەدایە کە دەیەوێت بابەتێکى نوێ لە بوارى تەکنەلۆژیاى پەیوەندیکردن و ڕۆژنامەوانى گەنگەشە بکات کە پێشتر توێژینەوەى زۆرکەمى لەبارەوەکراوە، لەهەمانکاتدا بابەتە جێ بایەخە لەو روانگەی کە گۆرانکارى زۆرى لە ژینگەى پراکتیکى رۆژنامەوانیدا دروستکردووە، ئەنجامەکانى ئەم توێژینەوەیە دەبێتە بنەمایەکى باش بۆ ڕۆژنامەوانان و ناوەندە زانستى و دامەزراوە ئەکادیمییەکانى هەرێمى کوردستان.	توێژینەوەکە لە جۆرى توێژینەوەی وەسفییە، توێژەران بۆ گەشتن بە ئامانجەکانى توێژینەوەکە، میتۆدى چۆنایەتییان بەکارهێناوە. سامپڵی توێژینەوەکە بە شێوەى مەبەستدار وەرگیراوە، کە بەشێکە لە سامپڵی نائەگەرى، ژماریەک لە مامۆستایی زانکۆ لە بوارى رۆژنامەوانى و چەند رۆژنامەوانێک وەک سامپڵی توێژینەوەکە وەرگیراوە. توێژینەوەکە بەچەند دەرئەنجامێک گەشتووە: 1- ئاڵنگارییە (ئەخلاقی و پیشەییەكان) ئەو ئاڵنگاریانەن ئەگەر بەووریایەوە مامەڵەیان لەگەڵ نەكرێت مەترسی لەسەر ژیانی تاك و پیشەی ڕۆژنامەوانان دروست دەكەن، دەتوانن ئاسایشی كۆمەڵگە تێكبدەن . 2- بەكارهێنانەكانی زیرەكی دەستكرد لە بواری ڕۆژنامەوانیدا لە ئێستادا خۆی لە كاری داڕشتنەوەی تێكست و دروستكردنی وێنە و ڤیدیۆ وبەكارهێنانی بۆ كاری مۆنتاژ و ئیدیتینگ دەبینیتەوە، هەروەها لەژووری هەواڵ بۆ شیكردنەوەی داتاكان و ووردبینیكردنی سودی لێوەردەگیریت . 3-	ژێرخانى تەکنیکى زیرەکى دەستکرد لە دامەزراوە رۆژنامەوانیە كوردییەكان لە ئاستێکى لاوازدایە، و عەقڵیەتی بەرێوەبردنی دامەزراوەكانیش ڕێگرە لە بەرەوپێشچوون و بەكارهێنانی زیرەكی دەستكرد، بۆیە ئاستى پشتبەستنى ئەو دامەزراوانە بەزیرەکى دەستکرد لە ئاستێکى زۆر سەرەتاییدایە.
ОРГАНІЗАЦІЙНО-ЕКОНОМІЧНИЙ МЕХАНІЗМ ЦИКЛУ УТИЛІЗАЦІЇ ШИН В НАЦІОНАЛЬНІЙ ГВАРДІЇ УКРАЇНИ
Authors: Коломійцев Олексій , Посохов Віталій , Дерев’янко Максим , Переход Сергій 
Published: August 2024

В роботі досліджено організаційно-економічний механізм циклу утилізації шин в Національній гвардії України (НГУ). Обґрунтована актуальність утилізації шин у частинах (підрозділах) НГУ, що викликано зростанням автомобільного парку колісної техніки та колісних технічних засобів, а також інтенсивністю їх використання та призвело до накопичення списаних шин на складах військових частин (підрозділів). Проведено аналіз нормативно-правової бази, яка регламентує питання утилізації списаних шин. Встановлено, що у сучасних умовах господарювання не вирішено питання щодо утилізації списаних шин та є актуальним науковим завданням. Розглянуто найбільш оптимальні процеси переробляння шин та визначений напрямок для прийняття управлінських рішень та змін нормативно-правової бази, які направлені на вирішення питань щодо утилізації списаних шин та подальшого використання продуктів утилізації. Наведено порівняльний аналіз запуску лінії переробки автомобільних шин в гумову крихту цивільним підприємством та підрозділом НГУ. Запропоновано ряд заходів, які спрямовані на вирішення завдання щодо утилізації списаних шин. Розроблено організаційно-економічний механізм циклу утилізації списаних шин, а також наданий моніторинг цін існуючих автоматичних ліній для подрібнення зношених шин, що пропонує сучасний ринок.