bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolution of deep angiosperm phylogeny using conserved nuclear genes and estimates of early divergence times
Authors: Zeng Liping , Zhang Qiang , Sun Renran , Kong Hongzhi , Zhang Ning , Ma Hong 
Published: September 2014

AbstractAngiosperms are the most successful plants and support human livelihood and ecosystems. Angiosperm phylogeny is the foundation of studies of gene function and phenotypic evolution, divergence time estimation and biogeography. The relationship of the five divergent groups of the Mesangiospermae (~99.95% of extant angiosperms) remains uncertain, with multiple hypotheses reported in the literature. Here transcriptome data sets are obtained from 26 species lacking sequenced genomes, representing each of the five groups: eudicots, monocots, magnoliids, Chloranthaceae and Ceratophyllaceae. Phylogenetic analyses using 59 carefully selected low-copy nuclear genes resulted in highly supported relationships: sisterhood of eudicots and a clade containing Chloranthaceae and Ceratophyllaceae, with magnoliids being the next sister group, followed by monocots. Our topology allows a re-examination of the evolutionary patterns of 110 morphological characters. The molecular clock estimates of Mesangiospermae diversification during the late to middle Jurassic correspond well to the origins of some insects, which may have been a factor facilitating early angiosperm radiation.
Similarity‐Based Modeling Applied to Signal Detection in Pharmacovigilance
Authors: Vilar S , Ryan PB , Madigan D , Stang PE , Schuemie MJ , Friedman C , Tatonetti NP , Hripcsak G 
Published: September 2014

One of the main objectives in pharmacovigilance is the detection of adverse drug events (ADEs) through mining of healthcare databases, such as electronic health records or administrative claims data. Although different approaches have been shown to be of great value, research is still focusing on the enhancement of signal detection to gain efficiency in further assessment and follow‐up. We applied similarity‐based modeling techniques, using 2D and 3D molecular structure, ADE, target, and ATC (anatomical therapeutic chemical) similarity measures, to the candidate associations selected previously in a medication‐wide association study for four ADE outcomes. Our results showed an improvement in the precision when we ranked the subset of ADE candidates using similarity scorings. This method is simple, useful to strengthen or prioritize signals generated from healthcare databases, and facilitates ADE detection through the identification of the most similar drugs for which ADE information is available.CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e137; doi:10.1038/psp.2014.35; published online 24 September 2014
A directional wave measurement attack against the Kish key distribution system
Authors: Gunn Lachlan J. , Allison Andrew , Abbott Derek 
Published: September 2014

AbstractThe Kish key distribution system has been proposed as a classical alternative to quantum key distribution. The idealized Kish scheme elegantly promises secure key distribution by exploiting thermal noise in a transmission line. However, we demonstrate that it is vulnerable to nonidealities in its components, such as the finite resistance of the transmission line connecting its endpoints. We introduce a novel attack against this nonideality using directional wave measurements and experimentally demonstrate its efficacy.
Hes7 3′UTR is required for somite segmentation function
Authors: Fujimuro Takeshi , Matsui Takaaki , Nitanda Yasuhide , Matta Tatsuro , Sakumura Yuichi , Saito Michiko , Kohno Kenji , Nakahata Yasukazu , Bessho Yasumasa 
Published: September 2014

AbstractA set of genes in the posterior end of developing mouse embryos shows oscillatory expression, thereby regulating periodic somite segmentation. Although the mechanism for generating oscillation has extensively been clarified, what regulates the oscillation period is still unclear. We attempted to elongate the oscillation period by increasing the time to transcribe Hes7 in this research. We generated knock-in mice, in which a large intron was inserted into Hes7 3′UTR. The exogenous intron was unexpectedly not properly spliced out and the transcripts were prematurely terminated. Consequently, Hes7 mRNA lost its 3′UTR, thereby reducing the amount of Hes7 protein. Oscillation was damped in the knock-in embryos and periodic somite segmentation does not occur properly. Thus, we demonstrated that Hes7 3′UTR is essential to accumulate adequate amounts of Hes7 protein for the somite segmentation clock that orchestrates periodic somite formation.
Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice
Authors: Park Hyeon Soo , Hwang Yong Hyeon , Kim Mun Ki , Hong Gyeong Eun , Lee Ho Jeong , Nagappan Arulkumar , Yumnam Silvia , Kim Eun Hee , Heo Jeong Doo , Lee Sang Joon , Won Chung Kil , Kim Gon Sup 
Published: September 2014

Abstract
Grifola frondosa (GF), distributed widely in far east Asia including Korea, is popularly used as traditional medicines and health supplementary foods, especially for enhancing the immune functions of the body. To extend the application of GF polysaccharides (GFP) for atopic dermatitis (AD), we investigated the effects of GFP on the 2,4-dinitrochlorobenzene-induced AD-like skin lesion in NC/Nga mice. GFP treatment significantly reduced the dorsa skin dermatitis score and combination treatment with GFP, and dexamethasone has a synergistic effect in AD-like skin lesion by reduced Serum IgE, mast cells infiltration, and cytokines expression. These results indicate that GFP suppressed the AD-like skin lesions by controlling the Th-1/Th-2-type cytokines in NC/Nga mice. These findings strongly suggest that GFP can be useful for AD patients as a novel therapeutic agent and might be used for corticosteroids replacement or supplement agent.
Aerobic, resistance and combined exercise training on arterial stiffness in normotensive and hypertensive adults: A review
Authors: Li Yanlei , Hanssen Henner , Cordes Mareike , Rossmeissl Anja , Endes Simon , Schmidt‐Trucksäss Arno 
Published: September 2014

AbstractExercise training has different effects on arterial stiffness according to training modalities. The optimal exercise modality for improvement of arterial function in normotensive and hypertensive individuals has not been well established. In this review, we aim to evaluate the effects of aerobic, resistance and combined aerobic and resistance training on arterial stiffness in individuals with and without hypertension. We systematically searched the Pubmed and Web of Science database from 1985 until December 2013 for relevant randomised controlled trials (RCTs). The data were extracted by one investigator and checked by a second investigator. The training effects on arterial stiffness were estimated using weighted mean differences of the relative changes (%) with 95% confidence intervals (CIs). We finally reviewed the results from 17 RCTs. The available evidence indicates that aerobic exercise tends to have a beneficial effect on arterial stiffness in normotensive and hypertensive patients, but does not affect arterial stiffness in patients with isolated systolic hypertension. Resistance exercise has differing effects on arterial stiffness depending on type and intensity. Vigorous resistance training is associated with an increase in arterial stiffness. There seem to be no unfavourable effects on arterial stiffness if the training is of low intensity, in a slow eccentric manner or with lower limb in healthy individuals. Combined training has neutral or even a beneficial effect on arterial stiffness. In conclusion, our review shows that exercise training has varying effects on arterial stiffness depending on the exercise modalities.
Comparability of accelerometer‐ and IPAQ‐derived physical activity and sedentary time in South Asian women: A cross‐sectional study
Authors: Curry Whitney Babakus , Thompson Janice L. 
Published: September 2014

AbstractThere is limited research documenting objectively measured physical activity (PA) and sedentary time (ST) in South Asian (SA) women, with no published evidence of the validity of self‐report methods for assessment of PA/ST in SA. The purpose of this study was to compare accelerometer‐ and International Physical Activity Questionnaire (IPAQ)‐derived PA/ST among SA women in the United Kingdom (UK) via a mixed‐methods approach. One hundred and forty SA women wore an accelerometer for seven consecutive days; a sub‐sample (n = 50) completed the IPAQ‐Short Form (IPAQ‐SF) and a brief structured interview. Accelerometer‐derived metabolic equivalent (MET) minutes per week (min/wk) moderate‐to‐vigorous physical activity (MVPA) (mean ± SD) for the full sample was 793.94 (±519.44) and mean accelerometer‐derived ST wk was 530.20 (±81.76). IPAQ‐SF‐derived MVPA (MET min/wk) was 636.80 (±2113.56) and mean ST wk was 315.31 (±266.98). Pearson correlations were not significant between accelerometer‐ and IPAQ‐SF‐assessed MVPA (r = −.119, p =. 579) and ST (r = −.140, p =. 229). Major themes synthesised from interviews included inability to recall sitting time and limited general knowledge of real‐life examples of MVPA. These results suggest that the IPAQ‐SF may not accurately measure PA/ST in the UK SA women. These findings are supported by qualitative evidence indicating several issues with interpretation and recall of PA/ST as assessed via this questionnaire.
Fewer eggs from larger size limits: counterintuitive outcomes in a spatially heterogeneous fishery
Authors: Gardner Caleb , Hartmann Klaas , Punt André E. , Hoshino Eriko 
Published: September 2014

Abstract
The legal minimum length (LML) of female Southern Rock Lobster (Jasus edwardsii) was reduced in the Tasmanian fishery in 1966 for higher sustainable catches. Originally, the LML was to be reduced in slow growth southern areas only; however, the change was implemented across the entire fishery due to lobbying by commercial fishers. The lower LML has been controversial ever since, including during recent years when low recruitment resulted in a lower total allowable catch (TAC). Fishers argued that this could have been prevented with a higher female LML across the jurisdiction. A length- and sex-based bioeconomic model was used to examine probable outcomes of the larger statewide LML. This model showed that management of egg production would be poorly served by raising the statewide LML because of spatial patterns in the stock and fishery. Catch would be displaced from areas where egg production was already high and into the most depleted areas thus reducing production in areas of greatest concern. Spatial variation in biological parameters can have a profound effect on outcomes of management perceived to be conservative, possibly leading to negative impacts. This risk exists wherever catch is displaced, such as with Marine Protected Areas, spatial TACs and gear restrictions.
Lamiophlomis rotata, an Orally Available Tibetan Herbal Painkiller, Specifically Reduces Pain Hypersensitivity States through the Activation of Spinal Glucagon-like Peptide-1 Receptors
Authors: Zhu Bin , Gong Nian , Fan Hui , Peng Chong-Sheng , Ding Xiu-Juan , Jiang Yi , Wang Yong-Xiang 
Published: September 2014

Abstract

Background:

Lamiophlomis rotata is an orally available Tibetan herb prescribed for the management of pain, with shanzhiside methylester (SM) and 8-O-acetyl-SM as quality control ingredients. This study aimed to evaluate the antinociceptive properties of L. rotata, determine whether SM and 8-O-acetyl-SM are principle effective ingredients, and explore whether L. rotata produces antinociception through activation of spinal glucagon-like peptide-1 receptors (GLP-1Rs).

Methods:
Formalin test, neuropathic pain, and bone cancer pain models were used, and the animal sample size was 5 to 6 in each group. Hydrogen peroxide–induced oxidative damage was also assayed.

Results:
The L. rotata aqueous extract blocked formalin-induced tonic hyperalgesia and peripheral nerve injury– and bone cancer–induced mechanical allodynia by 50 to 80%, with half-effective doses of 130 to 250 mg/kg, close to the human dosage. The herb was not effective in alleviating acute nociceptive pain. A 7-day gavage with L. rotata aqueous extract did not lead to antiallodynic tolerance. Total iridoid glycosides, rather than total flavonoids, were identified by the activity-tracking method as effective ingredients for antihyperalgesia, whereas both SM and 8-O-acetyl-SM were principal components. Further demonstrations using the GLP-1R antagonist and gene silencer against GLP-1R at both the spinal and the cellular levels indicated that L. rotata inhibited pain hyperactivity by activation of spinal GLP-1Rs, and SM and 8-O-acetyl-SM appeared to be orthosteric, reversible, and fully intrinsic agonists of both rat and human GLP-1Rs.

Conclusions:
Results support the notion that the activation of spinal GLP-1Rs leads to specific antinociception in pain hypersensitivity and further suggest that GLP-1R is a human-validated target molecule for the treatment of chronic pain.
Outcomes of Aortic Valve and Concomitant Ascending Aorta Replacement Performed via a Minimally Invasive Right Thoracotomy Approach
Authors: LaPietra Angelo , Santana Orlando , Pineda Andrés M. , Mihos Christos G. , Lamelas Joseph 
Published: September 2014

Objective Replacement of the aortic valve with concomitant replacement of the ascending aorta performed via a minimally invasive right anterior thoracotomy approach has not been reported. We evaluated the feasibility and safety of this procedure. Methods We retrospectively reviewed all minimally invasive aortic valve replacements (AVRs) with concomitant replacement of the ascending aorta performed at our institution between January 1, 2012, and December 30, 2012. The operative times, intensive care unit and hospital lengths of stay, postoperative outcomes, as well as mortality were analyzed. Results A total of 20 consecutive patients who underwent minimally invasive AVR with concomitant replacement of the ascending aorta were identified. There were 16 men (80%), with a mean (SD) age of 61 (13) years. The mean (SD) left ventricular ejection fraction was 58% (8%). The aortic valve was bicuspid in 18 patients (80%), with 14 (70%) being stenotic. The median aortic cross-clamp and cardiopulmonary bypass times were 163 [interquartile range (IQR), 141–170] minutes and 291 (IQR, 177–215) minutes, respectively. Hypothermic circulatory arrest was required in 19 patients (95%), with a median hypothermic circulatory arrest time of 35 (IQR, 33–39.5) minutes. The median intensive care unit and hospital lengths of stay were 24 (IQR, 23–41) hours and 5 (IQR, 4–6) days, respectively. There were no strokes, reoperations for bleeding, or conversions to sternotomy. The 30-day mortality was zero. Conclusions Minimally invasive AVR with concomitant replacement of the ascending aorta, via a right anterior thoracotomy approach, can be performed with low morbidity and mortality.
Assessing the Metabolic Impact of Nitrogen Availability Using a Compartmentalized Maize Leaf Genome-Scale Model
Authors: Simons Margaret , Saha Rajib , Amiour Nardjis , Kumar Akhil , Guillard Lenaïg , Clément Gilles , Miquel Martine , Li Zhenni , Mouille Gregory , Lea Peter J. , Hirel Bertrand , Maranas Costas D. 
Published: September 2014

AbstractMaize (Zea mays) is an important C4 plant due to its widespread use as a cereal and energy crop. A second-generation genome-scale metabolic model for the maize leaf was created to capture C4 carbon fixation and investigate nitrogen (N) assimilation by modeling the interactions between the bundle sheath and mesophyll cells. The model contains gene-protein-reaction relationships, elemental and charge-balanced reactions, and incorporates experimental evidence pertaining to the biomass composition, compartmentalization, and flux constraints. Condition-specific biomass descriptions were introduced that account for amino acids, fatty acids, soluble sugars, proteins, chlorophyll, lignocellulose, and nucleic acids as experimentally measured biomass constituents. Compartmentalization of the model is based on proteomic/transcriptomic data and literature evidence. With the incorporation of information from the MetaCrop and MaizeCyc databases, this updated model spans 5,824 genes, 8,525 reactions, and 9,153 metabolites, an increase of approximately 4 times the size of the earlier iRS1563 model. Transcriptomic and proteomic data have also been used to introduce regulatory constraints in the model to simulate an N-limited condition and mutants deficient in glutamine synthetase, gln1-3 and gln1-4. Model-predicted results achieved 90% accuracy when comparing the wild type grown under an N-complete condition with the wild type grown under an N-deficient condition.
The Small Regulatory RNA SyR1/PsrR1 Controls Photosynthetic Functions in Cyanobacteria
Authors: Georg Jens , Dienst Dennis , Schürgers Nils , Wallner Thomas , Kopp Dominik , Stazic Damir , Kuchmina Ekaterina , Klähn Stephan , Lokstein Heiko , Hess Wolfgang R. , Wilde Annegret 
Published: September 2014

Abstract
Little is known so far about RNA regulators of photosynthesis in plants, algae, or cyanobacteria. The small RNA PsrR1 (formerly SyR1) has been discovered in Synechocystis sp PCC 6803 and appears to be widely conserved within the cyanobacterial phylum. Expression of PsrR1 is induced shortly after a shift from moderate to high-light conditions. Artificial overexpression of PsrR1 led to a bleaching phenotype under moderate light growth conditions. Advanced computational target prediction suggested that several photosynthesis-related mRNAs could be controlled by PsrR1, a finding supported by the results of transcriptome profiling experiments upon pulsed overexpression of this small RNA in Synechocystis sp PCC 6803. We confirmed the interaction between PsrR1 and the ribosome binding regions of the psaL, psaJ, chlN, and cpcA mRNAs by mutational analysis in a heterologous reporter system. Focusing on psaL as a specific target, we show that the psaL mRNA is processed by RNase E only in the presence of PsrR1. Furthermore, we provide evidence for a posttranscriptional regulation of psaL by PsrR1 in the wild type at various environmental conditions and analyzed the consequences of PsrR1-based regulation on photosystem I. In summary, computational and experimental data consistently establish the small RNA PsrR1 as a regulatory factor controlling photosynthetic functions.
Benchmarking of industrial park infrastructures in Germany
Authors: Festel Gunter , Würmseher Martin 
Published: September 2014

Purpose– The purpose of this paper is to evaluate the operational performance of industrial park infrastructures in Germany to find first indications for cost saving potentials.Design/methodology/approach– Between 2006 and 2007, six chemical parks and chemical related industrial parks in Germany participated in a benchmarking study with focus on operation and maintenance of buildings, communication infrastructures and traffic infrastructures. Based on data analysis in combination with workshops, numerous key performance indicators were defined and calculated.Findings– To compare the different complexities of the analysed infrastructures, the most important key performance indicators were adjusted using correction factors defined and verified during the workshops. This made a discussion based on comparable and comprehensible figures possible which increased the acceptance and applicability of the benchmarking methodology. The benchmarking results showed large differences in performance levels, indicating that there are significant cost saving potentials in some industrial parks.Research limitations/implications– The comparability may remain limited due to the partly insufficient availability of data from the participants. Other limitations are due to the small number of investigated industrial parks and the focus of the benchmarking study on Germany.Originality/value– The developed benchmark and best practice methodology is well suited to evaluate best practice in the field of industrial park infrastructures. It is important for industrial parks to understand the individual performance level and to adapt best practice in all areas.
An i-AHP&QFD warranty model
Authors: Jenab Kouroush , Pourmohammadi Hamid , Sarfaraz Matin 
Published: September 2014

Purpose
– The purpose of this paper is to present a new warranty model to improve warranty management. As a case study, the developed model has been applied on an industrial vehicle manufacturing company. The model is composed of quality function deployment (QFD) and interval-based analytical hierarchy process (i-AHP). The i-AHP is an extension of the concept of analytical hierarchy process (AHP) that takes the benefits of interval computations in order to mitigate the shortcomings of AHP and fuzzy AHP.

Design/methodology/approach
– Using a combination of i-AHP and QFD, the authors analyzed the several options and alternatives available, weighting each one by means of an interval pair-wise comparison. Using collected data, the authors have shown how to map the capability of each option against each alternative and thereby build a relationship matrix under the QFD approach based on interval computations.

Findings
– The use of i-AHP&QFD integrated methodology helps to identify the best options to solve several decision problems in diverse fields and could be applied successfully in warranty management. This methodology is especially useful when dealing with several options and equal numbers of alternatives for each warranty option.

Research limitations/implications
– The case study includes competitiveness analysis at the first house of quality (HOQ), but not at the subsequent HOQ, due to a lack of information from the relevant competitors. However, the paper demonstrates the kind of competitiveness analysis at the first HOQ which can be extended to all subsequent HOQs.

Practical implications
– The research would be useful to academics and practitioners in developing integrated versions of the QFD and i-AHP methodologies to improve warranties.

Originality/value
– This study contributes to the diffusion of a new form of integrated warranty model, through the presentation of practical examples of industrial vehicle warranty management. Also, the model presents the i-AHP in order to quantify and compare variables via the use of geometrical averages and to synthesize a subsequent solution.