bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphine compromises bronchial epithelial TLR2/IL17R signaling crosstalk, necessary for lung IL17 homeostasis
Authors: Banerjee Santanu , Ninkovic Jana , Meng Jingjing , Sharma Umakant , Ma Jing , Charboneau Richard , Roy Sabita 
Published: June 2015

AbstractOpportunistic lung infection and inflammation is a hallmark of chronic recreational/clinical use of morphine. We show that early induction of IL17 from the bronchial epithelium, following pathogenic encounter is a protective response, which contributes to pathogenic clearance and currently attributed to TLR2 activation in immune cells. Concurrent activation of TLR2 and IL17R in bronchial epithelium results in the sequestration of MyD88 (TLR2 adapter) by Act1/CIKS (IL17R adapter), thereby turning off TLR2 signaling to restore homeostasis. Morphine inhibits the early IL17 release and interaction between Act1 and MyD88, leading to decreased pathogenic clearance and sustained inflammation. Hence, we propose that therapeutically targeting either TLR2 or IL17 in bronchial epithelia, in the context of morphine, can restore inflammatory homeostasis.
Achieving waste to energy through sewage sludge gasification using hot slags: syngas production
Authors: Sun Yongqi , Nakano Jinichiro , Liu Lili , Wang Xidong , Zhang Zuotai 
Published: June 2015

AbstractTo relieve the environmental issues of sewage sludge (SS) disposal and greenhouse gas (GHG) emission in China, we proposed an integrated method for the first time to simultaneously deal with these two problems. The hot slags below 920 °C could act as a good heat carrier for sludge gasification and the increasing CO2 concentration in CO2/O2 atmospheres enhanced the production of CO and H2 at 400–800 °C. Three stages of syngas release were clearly identified by Gaussian fittings, i.e., volatile release, char transformation and fixed carbon reaction. Additionally, the effect of sulfur retention of slags and the synergy effect of the stabilization of toxic elements in the solid residuals were discovered in this study. Furthermore, a novel prototype of multiple industrial and urban systems was put forward, in which the produced CO + H2 could be utilized for direct reduced iron (DRI) production and the solid residuals of sludge ash and glassy slags would be applied as cementitious materials. For a steel plant with an annual production of crude steel of 10 million tons in China, the total annual energy saving and GHG emission reduction achieved are 3.31*105 tons of standard coal and 1.74*106 tons of CO2, respectively.
Super-resolution of fluorescence-free plasmonic nanoparticles using enhanced dark-field illumination based on wavelength-modulation
Authors: Zhang Peng , Lee Seungah , Yu Hyunung , Fang Ning , Ho Kang Seong 
Published: June 2015

AbstractSuper-resolution imaging of fluorescence-free plasmonic nanoparticles (NPs) was achieved using enhanced dark-field (EDF) illumination based on wavelength-modulation. Indistinguishable adjacent EDF images of 103-nm gold nanoparticles (GNPs), 40-nm gold nanorods (GNRs) and 80-nm silver nanoparticles (SNPs) were modulated at their wavelengths of specific localized surface plasmon scattering. The coordinates (x, y) of each NP were resolved by fitting their point spread functions with a two-dimensional Gaussian. The measured localization precisions of GNPs, GNRs and SNPs were 2.5 nm, 5.0 nm and 2.9 nm, respectively. From the resolved coordinates of NPs and the corresponding localization precisions, super-resolution images were reconstructed. Depending on the spontaneous polarization of GNR scattering, the orientation angle of GNRs in two-dimensions was resolved and provided more elaborate localization information. This novel fluorescence-free super-resolution method was applied to live HeLa cells to resolve NPs and provided remarkable sub-diffraction limit images.
Reconfigurable multi‐band radio‐frequency transceiver based on photonics technology for future optical wireless communications
Authors: Borges Ramon Maia , Rodovalho Tércio Naves , Cerqueira Sodré Junior Arismar 
Published: June 2015

This study presents the concept and the implementation of a fully photonics‐based and reconfigurable multi‐band radio‐frequency (RF) transceiver for future optical‐wireless communications networks. The proposed device is based on frequency multiplication using optical external modulation technique, which enables to achieve discrete tuning of the wireless frequency by simply manipulating the modulator bias voltage. The physical mechanism behind the frequency multiplication is analytically explained and experimentally demonstrated by generating RF carriers at 5.2 GHz with signal‐to‐noise ratio of up to 54 dB. High spectral purity, distortion absence and low phase noise of the generated RF signals have been observed. Furthermore, the photonics‐based reconfigurable RF transceiver has been implemented and tested in a real optical‐wireless network from the telecom operator Telecom Italia Mobile using a femtocell base station. Data transmission and a high‐quality voice call have been realised using the proposed approach in order to illustrate its applicability.
Grape seed proanthocyanidin extracts prevent high glucose-induced endothelia dysfunction via PKC and NF-κB inhibition
Authors: Jiang Yanfei , Li Yujie , Ding Ye , Dai Xiaoqian , Ma Xiaotao , Bao Lei , Zhang Zhaofeng , Li Yong 
Published: June 2015

AbstractIn our study, it has been detected in vivo and in vitro that GSPE reversed high glucose-induced the increase of ICAM-1 and VCAM-1. It is shown that by western blotting detection, GSPE significantly inhibited the activation of NF-κB induced by high glucose while there was significant decrease of the expression of PKC with GSPE intervention. By adding the NF-κB blocker PDTC and the PKC inhibitor peptide 19–31(10−6 M), no significant difference was found in the levels of VCAM-1 and ICAM-1 among GSPE group, the PKC inhibitor peptide 19–31-added GSPE group and the PDTC-added GSPE group. So the conclusion could be drawn that PKC inhibition must be involved in GSPE decreasing the level of ICAM-1 and VCAM-1.We proved for the first time that GSPE prevented high glucose-induced the increase of ICAM-1 and VCAM-1 by PKC and NF-κB inhibition. These findings show a novel mechanism of the action GSPE preventing endothelial dysfunction, which may have clinical application values.
Scholarly impact in the organizational sciences in and from Iberoamerica
Authors: Kausel Edgar E. 
Published: June 2015

Purpose– The purpose of this paper is to offer the author’s view about the conceptualization of scholarly impact, and some of the challenges young Iberoamerican scholars face to have an impact.Design/methodology/approach– This is a personal account based on previous theory and the author’s personal experience.Findings– The paper presents a short critique of the conceptualization and measurement of scholarly impact, and introduces dimensions and challenges of being a scholar in Iberoamerica.Originality/value– The paper offers an analytical perspective of scholarly impact in Iberoamerica and offers some insights to help overcome different challenges.
Perceptions of corporate social responsibility, organizational commitment and job satisfaction
Authors: Closon Caroline , Leys Christophe , Hellemans Catherine 
Published: June 2015

Purpose– This paper aims to, first, investigate the impact of corporate social responsibility (CSR)’s various dimensions on organizational commitment and job satisfaction, and, second, to examine the moderating role of employee expectations in this relationship. Studies have increasingly focused the attention on the links between perceptions of CSR and employees’ attitudes. However, a majority of studies do concentrate on internal CSR impact.Design/methodology/approach– A field study based on data from 621 workers. The constructs were measured by validated self-report questionnaires.Findings– The results show that ethical and legal internal and external practices significantly influence the affective organizational commitment. The results also indicate that job satisfaction is positively influenced by internal and external ethico-legal practices as well as by philanthropic practices. Nonetheless, the role of expectation as moderator could not be demonstrated. This matter is discussed in the section dedicated to the limitations of the study.Originality/value– The originality of the contribution is undoubtedly to have integrated the concept of citizen-worker in this research on CSR.
Generational perceptions and their influences on organizational commitment
Authors: Silva Rodrigo Cunha da , Dutra Joel Souza , Veloso Elza Fátima Rosa , Fischer André  Luiz , Trevisan Leonardo Nelmi 
Published: June 2015

Purpose
– This study aims to investigate the existence of delimitations more suited to the emergence of generations in Brazil, and to assess generational perceptions on constructs of the work environment and their influences on organizational commitment.

Design/methodology/approach
– The perceptions of 102,540 respondents employed by 394 organizations were classified into nine constructs. The methodology used entailed an initial confirmatory factorial analysis, which was undertaken to investigate the validity of the proposed measurement model. Regression analyses were applied to test the relationship between work environment and commitment.

Findings
– The results highlight that the Baby Boomer generation attributed more value to the meaning of work and corporate social responsibility. Meaning of work, learning and development were given a high level of importance in the results for Generation X. Generation Y values learning and development, relationships with co-workers and Work-life balance more than the other two generations.

Research limitations/implications
– This research is classified as a cross-sectional study that does not allow us to substantiate whether differences between the groups were caused by influence of generations or the age of respondents. Therefore, nationwide surveys capable of offsetting the age effect on generational differences are still necessary. Another constraint is related to the fact that only data from the survey that annually elects the “Best Companies to Work for in Brazil” were used for undertaking this study. Moreover, because all variables were collected simultaneously from the same source, the authors recognize that the results could have problems related to common method biases.

Practical implications
– The authors believe that the identification of critical dimensions of workers’ perception regarding the work environment equips human resources professionals with the ability to implement policies and practices that align people management with the differing desires of each generation, effectively ensuring commitment from these professionals.

Social implications
– This study may contribute to researchers by highlighting the need for temporal outlines suited to the Brazilian reality, which might also inspire further research on the country’s generations, even associating them with other themes, such as values, personality and professional motivation.

Originality/value
– As the main contributions, the authors have sought to highlight that generational differences may be related to specific periods in each country’s historical context. The authors also show the determining factors influencing each generation’s affective commitment and justify each of their choices.
The media of sociology: tight or loose translations?
Authors: Guggenheim Michael 
Published: June 2015

AbstractSociologists have increasingly come to recognize that the discipline has unduly privileged textual representations, but efforts to incorporate visual and other media are still only in their beginning. This paper develops an analysis of the ways objects of knowledge are translated into other media, in order to understand the visual practices of sociology and to point out unused possibilities. I argue that the discourse on visual sociology, by assuming that photographs are less objective than text, is based on an asymmetric media‐determinism and on a misleading notion of objectivity. Instead, I suggest to analyse media with the concept of translations. I introduce several kinds of translations, most centrally the distinction between tight and loose ones. I show that many sciences, such as biology, focus on tight translations, using a variety of media and manipulating both research objects and representations. Sociology, in contrast, uses both tight and loose translations, but uses the latter only for texts. For visuals, sociology restricts itself to what I call ‘the documentary’: focusing on mechanical recording technologies without manipulating either the object of research or the representation. I conclude by discussing three rare examples of what is largely excluded in sociology: visual loose translations, visual tight translations based on non‐mechanical recording technologies, and visual tight translations based on mechanical recording technologies that include the manipulation of both object and representation.
Improving Hospital Reporting of Patient Race and Ethnicity—Approaches to Data Auditing
Authors: Zingmond David S. , Parikh Punam , Louie Rachel , Lichtensztajn Daphne Y. , Ponce Ninez , Hasnain‐Wynia Romana , Gomez Scarlett Lin 
Published: June 2015

ObjectiveTo investigate new metrics to improve the reporting of patient race and ethnicity (R/E) by hospitals.Data SourcesCalifornia Patient Discharge Database (PDD) and birth registry, 2008–2009, Healthcare and Cost Utilization Project's State Inpatient Database, 2008–2011, cancer registry 2000–2008, and 2010USCensus Summary File 2.Study DesignWe examined agreement between hospital reported R/E versus self‐report among mothers delivering babies and a cancer cohort in California. Metrics were created to measure root mean squared differences (RMSD) by hospital between reported R/E distribution and R/E estimates using R/E distribution within each patient's zip code of residence.RMSDcomparisons were made to corresponding “gold standard” facility‐level measures within the maternal cohort for California and six comparison states.Data CollectionMaternal birth hospitalization (linked to the state birth registry) and cancer cohort records linked to preceding and subsequent hospitalizations. Hospital discharges were linked to the corresponding Census zip code tabulation area using patient zip code.Principal FindingsOverall agreement between thePDDand the gold standard for the maternal cohort was 86 percent for the combined R/E measure and 71 percent for race alone. TheRMSDmeasure is modestly correlated with the summary level gold standard measure for R/E (r = 0.44). TheRMSDmetric revealed general improvement in data agreement and completeness across states. “Other” and “unknown” categories were inconsistently applied within inpatient databases.ConclusionsComparison between reported R/E and R/E estimates using zip code level data may be a reasonable first approach to evaluate and track hospital R/E reporting. Further work should focus on using more granular geocoded data for estimates and tracking data to improve hospital collection of R/E data.
Use of a syndromic surveillance system to describe the trend in cycling‐related presentations to emergency departments in Sydney
Authors: Dinh Michael M , Kastelein Christopher , Bein Kendall J , Green Timothy C , Bautovich Tanya , Ivers Rebecca 
Published: June 2015

AbstractObjectivesTo describe population‐based trends in cycling‐related presentations to EDs over the past decade.MethodsA retrospective cohort of road trauma patients (motor vehicle, motor cyclist, cyclist and pedestrian) presenting to EDs in the Sydney Greater Metropolitan Area between 2004 and 2013 was obtained using the Public Health Real‐time Emergency Department Surveillance System. The outcomes of interest were the cycling‐related ED presentation rate per 1000 population, as well as the proportion of cycling‐related presentations that died in ED or were admitted to a critical care ward. Trends in ED presentation rates based on presentation counts and Sydney population data were plotted and described.ResultsThere were 68 438 cycling‐related presentations identified, representing 30% of all road trauma patients presenting to EDs in Sydney. There was a 91% increase in cycling‐related presentations for the 35 to 64‐year‐old age group and a 123% increase in cycling‐related presentations in the 65‐year‐old and over age group. All other age groups were associated with a stable or decrease in cycling‐related ED presentation rates. The proportion of presentations requiring critical care ward admission or death in ED has decreased by 20%.ConclusionUsing an ED syndromic surveillance system, cycling‐related ED presentation rates in Sydney Australia have increased in those aged 35 years and over the past 10 years, with a relative decrease in the proportion of deaths in ED or those requiring critical care admission.
Regional and Temporal Differences in Nitrate Trends Discerned from Long‐Term Water Quality Monitoring Data
Authors: Stets E.G. , Kelly V.J. , Crawford C.G. 
Published: June 2015

AbstractRiverine nitrate (NO3) is a well‐documented driver of eutrophication and hypoxia in coastal areas. The development of the elevated river NO3 concentration is linked to anthropogenic inputs from municipal, agricultural, and atmospheric sources. The intensity of these sources has varied regionally, through time, and in response to multiple causes such as economic drivers and policy responses. This study uses long‐term water quality, land use, and other ancillary data to further describe the evolution of river NO3 concentrations at 22 monitoring stations in the United States (U.S.). The stations were selected for long‐term data availability and to represent a range of climate and land‐use conditions. We examined NO3 at the monitoring stations, using a flow‐weighting scheme meant to account for interannual flow variability allowing greater focus on river chemical conditions. River NO3 concentration increased strongly during 1945‐1980 at most of the stations and have remained elevated, but stopped increasing during 1981‐2008. NO3 increased to a greater extent at monitoring stations in the Midwest U.S. and less so at those in the Eastern and Western U.S. We discuss 20th Century agricultural development in the U.S. and demonstrate that regional differences in NO3 concentration patterns were strongly related to an agricultural index developed using principal components analysis. This unique century‐scale dataset adds to our understanding of long‐term NO3 patterns in the U.S.
Making an Almost Joyful Noise: Augustan Imitation and the Psalms of David
Authors: Lund Roger 
Published: June 2015

AbstractThis essay examines the transformation of psalmody in the long eighteenth century, from metrical translation set to music and sung by an English congregation into a purely literary imitation designed to be appreciated like any other form of modern poetry. Under the influence of an Augustan theory of poetic imitation, poets move beyond simple paraphrase or translation to create a new literary commodity. While these poems identify themselves as Psalms, assuming the cachet of scriptural authority, they seem largely unrelated to worship or liturgy; they are intended not so much to express private devotion as to ‘amuse’ ingenious readers.
Computed tomography‐guided percutaneous microwave ablation of early stage non‐small cell lung cancer in a pneumonectomy patient
Authors: Wei Zhigang , Wang Jiao , Ye Xin , Yang Xia , Huang Guanghui 
Published: June 2015

AbstractA squamous cell lung cancer patient was treated with pneumonectomy. A recurrent lung cancer (adenocarcinoma) was found 45 months later and successfully biopsied and treated with microwave ablation. After 18 months of follow up, no evidence of tumor recurrence was observed.
Disease recurrence and survival in patients with multifocal breast cancer: a follow‐up study with 7‐year results
Authors: Kuan Li Lian , Tiong Leong Ung , Parkyn Robert , Walters David , Lai Christine , Walsh David 
Published: June 2015

AbstractBackgroundFew studies have shown that multifocal breast cancer (MBC) has poorer outcomes compared with unifocal breast cancer (UBC). Currently, there is no long‐term data on disease recurrence and survival in patients with MBC. The aim of this study is to evaluate whether patients with MBC have worse outcomes compared with UBC in respect to disease recurrence and survival.MethodsThis is a retrospective study of patients diagnosed with stage I–III MBC from 2000 to 2007 in comparison with UBC with a median follow‐up of 7 years. Prognostic factors were prospectively collected from the breast cancer unit database. Univariate and multivariable analyses for disease recurrence and survival were performed as well as Kaplan–Meier curves.ResultsA total of 152 patients were included; 75 with MBC, 77 with UBC. The multifocal group was treated more aggressively with mastectomy (73% versus 25%, P < 0.0001) and chemotherapy (53% versus 42%). Breast cancer recurred in nine (11.7%) patients in the UBC group and nine (12%) patients in the MBC group respectively (hazard ratio (HR): 1.13, 95% confidence interval (CI): 0.45–2.86, P = 0.794). There were 10 (13%) mortalities in the unifocal group as compared with 11 (14.7%) in the multifocal group (HR: 1.02, 95% CI: 0.42–2.48, P = 0.969). There were no statistically significant differences in the all‐cause mortality and disease recurrence rates between both groups.DiscussionThere were no statistically significant differences in disease recurrence or mortality rates between MBC and UBC at a median follow‐up of 7 years. However, patients in the MBC group received more aggressive treatment than the unifocal group.
Synchronous colorectal liver metastases in pregnancy and post‐partum
Authors: Robson Danielle E. , Lewin Joel , Cheng Anthony W. , O'Rourke Nicholas A. , Cavallucci David J. 
Published: June 2015

AbstractBackgroundMetastatic colorectal cancer (mCRC) in pregnancy and post‐partum is rare, but represents significant diagnostic and therapeutic challenges for clinicians. A multidisciplinary team (MDT) approach is essential. This study reports the first series in the Australasian literature, describing our experience with and management of pregnant and post‐partum patients diagnosed with synchronous colorectal liver metastases (sCRLM).MethodA retrospective review of prospectively collected data for patients with sCRLM diagnosed during pregnancy or post‐partum, presenting to a tertiary referral hospital between 2009 and 2014, was performed. Data regarding patient presentation, imaging, management, histopathology and survival were analysed. Patient characteristics and outcomes were reviewed, including age, presenting complaint and median survival.ResultsFive patients were identified with sCRLM: three patients were diagnosed antepartum and two post‐partum. Median age was 31 years (range 26–34). All patients were diagnosed with colorectal primary and synchronous liver lesions. All patients received folinic acid, fluorouracil, oxaliplatin chemotherapy, two intrapartum. One patient had both the primary lesion and liver metastases excised early post‐partum. Second‐line chemotherapy with folinic acid, fluorouracil, irinotecan and other biological agents was used in some cases post‐partum. One patient suffered a fetal loss, while the other four had uncomplicated live births. Median survival was 7.6 months, with two patients dying shortly after delivery.ConclusionThe diagnosis of mCRC in pregnancy is challenging and survival is poor. A MDT approach to management is essential. Chemotherapy remains the mainstay of treatment from the second trimester. Rapid confirmation of diagnosis and early chemotherapy, followed by post‐partum colorectal and liver resection may improve survival.