bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient Bayesian inference using physics-informed invertible neural networks for inverse problems
Authors: Guan Xiaofei , Wang Xintong , Wu Hao , Yang Zihao , Yu Peng 
Published: July 2024

Abstract
This paper presents an innovative approach to tackle Bayesian inverse problems using physics-informed invertible neural networks (PI-INN). Serving as a neural operator model, PI-INN employs an invertible neural network (INN) to elucidate the relationship between the parameter field and the solution function in latent variable spaces. Specifically, the INN decomposes the latent variable of the parameter field into two distinct components: the expansion coefficients that represent the solution to the forward problem, and the noise that captures the inherent uncertainty associated with the inverse problem. Through precise estimation of the forward mapping and preservation of statistical independence between expansion coefficients and latent noise, PI-INN offers an accurate and efficient generative model for resolving Bayesian inverse problems, even in the absence of labeled data. For a given solution function, PI-INN can provide tractable and accurate estimates of the posterior distribution of the underlying parameter field. Moreover, capitalizing on the INN’s characteristics, we propose a novel independent loss function to effectively ensure the independence of the INN’s decomposition results. The efficacy and precision of the proposed PI-INN are demonstrated through a series of numerical experiments.
State-level structural racism and adolescent mental health in the United States
Authors: Adkins-Jackson Paris B , Joseph Victoria A , Ford Tiffany N , Avila-Rieger Justina F , Gobaud Ariana N , Keyes Katherine M 
Published: July 2024

Abstract
We explored state-level indicators of structural racism on internalizing symptoms of depressive affect among US adolescents. We merged 16 indicators of state-level structural racism with 2015-19 Monitoring the Future surveys (n = 41 258) examining associations with loneliness, self-esteem, self-derogation, and depressive symptoms using regression analyses. Students racialized as Black in states with bans on food stamp eligibility and temporary assistance for drug felony conviction had 1.37 times the odds of high depressive symptoms (95% confidence interval [CI], 1.01-1.89) compared to students in states without bans. In contrast, students racialized as White living in states with more severe disenfranchisement of people convicted of felonies had lower odds of high self-derogation (odds ratio [OR], 0.89; 95% CI, 0.78-1.02) and high depressive symptoms (OR, 0.83; 95% CI, 0.70-0.99) compared to states with less severe disenfranchisement. These findings demonstrate the need to address the legacy of structural racism at the state level to reduce mental distress for US youth.
This article is part of a Special Collection on Mental Health.
Exposure to structural racism–related state laws is associated with worse cardiovascular health among US adults, BRFSS 2011 and 2013
Authors: Needham Belinda L , Dokshina Darya , Ali Talha , Allgood Kristi L , Douglas Megan , Dulin Akilah , Fleischer Nancy L , Johnson Amber E , Ro Annie , Agénor Madina 
Published: July 2024

Abstract
The objective of this study was to determine whether exposure to structural racism–related state laws is associated with cardiovascular health among a racially and ethnically diverse sample of US adults. Data were from the Database of Structural Racism–Related State Laws and the Behavioral Risk Factor Surveillance System (BRFSS). The sample included 958 019 BRFSS 2011 and 2013 respondents aged 18 years or older from all 50 US states. The exposure was a summary index of 22 state laws related to the criminal legal system, economics and labor, education, health care, housing, immigration, and political participation. The outcome was the American Heart Association’s Life’s Simple 7 (LS7), a summary index of 7 cardiovascular health indicators. Linear regression models included fixed effects for year and state to control for time trends and unmeasured, time-invariant, state-level contextual factors. In the full sample, a 1 SD increase in the structural racism state legal index was associated with a 0.06-unit decrease in the LS7 (b = −0.06; 95% CI, −0.09 to 0.02; P = .001), controlling for individual- and state-level covariates. Contrary to expectations, stratified models revealed no statistically significant differences by race and ethnicity in the association between the structural racism state legal index and the LS7.
Trends in and characteristics of drug overdose morbidity among pregnant and postpartum individuals in California, 2010-2018
Authors: Goldman-Mellor Sidra , Jensen Jordan , Cruz Shaina Sta , Olfson Mark , Gemmill Alison , Yan Yueqi , Margerison Claire 
Published: July 2024

Abstract
Fatal drug overdoses among pregnant and postpartum individuals have risen dramatically over the past 10 years. Trends in and characteristics of nonfatal drug overdoses in this population, however, remain unknown, despite the importance of this outcome for maternal and infant health. We used statewide, longitudinally linked hospital and emergency department administrative claims data from California to characterize the incidence, trends, drug type involvement, and sociodemographic disparities in pregnancy-associated drug overdose between 2010 and 2019. Generalized linear models accounting for multiple deliveries per individual were used to test for trends; descriptive statistics were used for other study analyses. Of California individuals with a live delivery between 2010 and 2018, approximately 0.2% had a pregnancy-associated drug overdose. Nonfatal overdoses were nearly 60 times more common than fatal overdoses. Incidence of overdoses involving stimulants increased in frequency, while incidence of overdoses involving sedative/hypnotic drugs and psychotropic medications decreased in frequency. Risk of overdose was substantially higher among delivering individuals who were young, non-Hispanic Black, Medicaid patients, or who lived in nonmetropolitan areas. Ongoing public health surveillance of pregnancy-associated nonfatal drug overdose events and clinical interventions to reduce these events are critical for prevention efforts.
Parity, faultlessness and relativism: A response to Wright and Ferrari
Authors: Zeman Dan 
Published: July 2024

Abstract
Crispin Wright and Filippo Ferrari have accused relativism of not accounting for ‘parity’ – the idea that, when we argue over matters of taste, we take our opponents’ opinions to be ‘as good as ours’ from our own committed perspective. In this paper, I show that (i) explaining parity has not been taken to be a desideratum by relativists and thus they cannot be accused of failing to fulfil a promise; (ii) Wright’s and Ferrari’s reasons for claiming that parity should be a desideratum are unconvincing.
Barking up the wrong frog: global prevalence of misdirected amplexus in anuran amphibians
Authors: Soni Shubham P , Apte Vaishnavi , Joshi Pranav , Cyriac Vivek P 
Published: July 2024

Abstract
Reproduction is an energy-expensive life process in many organisms, and accurate conspecific recognition is crucial to successful reproduction. Nonetheless, misdirected attempts at amplexus towards heterospecifics appear to be common in many anuran amphibians. Such reproductive interference can have significant ecological and evolutionary consequences, but its prevalence remains unknown. Here, we compile a global dataset of anuran misdirected amplexus and test how phylogenetic relatedness, ecological niche, breeding phenology, and geography influence the prevalence of anuran misdirected amplexus. We find misdirected amplexus to be significantly higher among more closely related heterospecific pairs than between random pairs, but still occurred between species of different families. Misdirected amplexus was also significantly more common in arboreal and terrestrial anurans, and among species pairs with similar body sizes or with similar microhabitat use. We also show that misdirected amplexus is significantly more common among explosive breeders compared with prolonged breeders and is more prevalent in temperate regions compared with the tropics. Overall, we show that misdirected amplexus among anuran amphibians is not a rare phenomenon and that its prevalence is influenced by evolutionary relatedness, microhabitat use, ecological similarity, and breeding phenology. These interactions have the potential to cause species decline, hence understanding them is crucial.
A case of IgG4-related disease manifesting as a spinal epidural mass
Authors: Chau Hatty Hoi Ting , Lo Bill Archie , Chu Wai Pong , Ho Ho Nam , Tsui Wilson Man-shan 
Published: July 2024

Abstract
IgG4-related disease is an immune-mediated fibroinflammatory condition. Isolated manifestation in the spine as hypertrophic pachymeningitis is very rare and the mass-like lesion on MRI often mimic tumour or infection. Patients would present with symptoms that result from mass effect or neurovascular compression. Studies showed that serum and CSF IgG4 levels are rarely informative, and therefore, tissue biopsy is crucial for accurate diagnosis. Apart from supporting the diagnosis, MRI is helpful in delineating the extent of disease and follow-up after treatment. A 18F-FDG PET/CT scan is useful in detecting systemic manifestations of IgG4-related disease. Although IgG4-related disease generally responds well to corticosteroid at inflammatory state, relapse is not uncommon. Current treatment strategies for IgG4-related hypertrophic pachymeningitis are high dose corticosteroid therapy and early decompressive surgery to avoid chronic neurological complications. We described a case of a 27-year-old gentleman complaining of lower limb weakness and numbness. MRI showed a mass-like epidural lesion at the thoracic spine causing cord compression. Open biopsy of the epidural mass demonstrated histopathological characteristics of IgG4-related disease. Patient responded well to early surgical decompression of the spinal cord and corticosteroid as evidenced by symptom improvement and resolving mass on subsequent MRI study. However, a follow-up MRI revealed disease recurrence years later.
A prefrontal–habenular circuitry regulates social fear behaviour
Authors: Tian Yuanyuan , Zheng Junqiang , Zhu Xiao , Liu Xue , Li Haoyang , Wang Jun , Yang Qian , Zeng Ling-Hui , Shi Zhiguo , Gong Mengyuan , Hu Yuzheng , Xu Han 
Published: July 2024

Abstract
The medial prefrontal cortex (mPFC) has been implicated in the pathophysiology of social impairments, including social fear. However, the precise subcortical partners that mediate mPFC dysfunction on social fear behaviour have not been identified.
Using a social fear conditioning paradigm, we induced robust social fear in mice and found that the lateral habenula (LHb) neurons and LHb-projecting mPFC neurons are activated synchronously during social fear expression. Moreover, optogenetic inhibition of the mPFC–LHb projection significantly reduced social fear responses. Importantly, consistent with animal studies, we observed an elevated prefrontal–habenular functional connectivity in subclinical individuals with higher social anxiety characterized by heightened social fear.
These results unravel a crucial role of the prefrontal–habenular circuitry in social fear regulation and suggest that this pathway could serve as a potential target for the treatment of social fear symptoms often observed in many psychiatric disorders.
Neural dysfunction underlying working memory processing at different stages of the illness course in schizophrenia: a comparative meta-analysis
Authors: Yao Yuhao , Zhang Shufang , Wang Boyao , Lin Xiaoyong , Zhao Gaofeng , Deng Hong , Chen Ying 
Published: July 2024

Abstract
Schizophrenia, as a chronic and persistent disorder, exhibits working memory deficits across various stages of the disorder, yet the neural mechanisms underlying these deficits remain elusive with inconsistent neuroimaging findings. We aimed to compare the brain functional changes of working memory in patients at different stages: clinical high risk, first-episode psychosis, and long-term schizophrenia, using meta-analyses of functional magnetic resonance imaging studies. Following a systematic literature search, 56 whole-brain task-based functional magnetic resonance imaging studies (15 for clinical high risk, 16 for first-episode psychosis, and 25 for long-term schizophrenia) were included. The separate and pooled neurofunctional mechanisms among clinical high risk, first-episode psychosis, and long-term schizophrenia were generated by Seed-based d Mapping toolbox. The clinical high risk and first-episode psychosis groups exhibited overlapping hypoactivation in the right inferior parietal lobule, right middle frontal gyrus, and left superior parietal lobule, indicating key lesion sites in the early phase of schizophrenia. Individuals with first-episode psychosis showed lower activation in left inferior parietal lobule than those with long-term schizophrenia, reflecting a possible recovery process or more neural inefficiency. We concluded that SCZ represent as a continuum in the early stage of illness progression, while the neural bases are inversely changed with the development of illness course to long-term course.
Polycomb repressive complex 2 is critical for mouse cortical glutamatergic neuron development
Authors: Currey Laura , Mitchell Benjamin , Al-Khalily Majd , McElnea Sarah-Jayne , Kozulin Peter , Harkins Danyon , Pelenyi Alexandra , Fenlon Laura , Suarez Rodrigo , Kurniawan Nyoman D , Burne Thomas H , Harris Lachlan , Thor Stefan , Piper Michael 
Published: July 2024

Abstract
The Polycomb Repressive Complex 2 (PRC2) regulates corticogenesis, yet the consequences of mutations to this epigenetic modifier in the mature brain are poorly defined. Importantly, PRC2 core genes are haploinsufficient and causative of several human neurodevelopmental disorders. To address the role of PRC2 in mature cortical structure and function, we conditionally deleted the PRC2 gene Eed from the developing mouse dorsal telencephalon. Adult homozygotes displayed smaller forebrain structures. Single-nucleus transcriptomics revealed that glutamatergic neurons were particularly affected, exhibiting dysregulated gene expression profiles, accompanied by aberrations in neuronal morphology and connectivity. Remarkably, homozygous mice performed well on challenging cognitive tasks. In contrast, while heterozygous mice did not exhibit clear anatomical or behavioral differences, they displayed dysregulation of neuronal genes and altered neuronal morphology that was strikingly different from homozygous phenotypes. Collectively, these data reveal how alterations to PRC2 function shape the mature brain and reveal a dose-specific role for PRC2 in determining glutamatergic neuron identity.
2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Utility of Blood Cultures in Adults, Children, and Pregnant People
Authors: Bonomo Robert A , Humphries Romney , Abrahamian Fredrick M , Bessesen Mary , Chow Anthony W , Dellinger E Patchen , Edwards Morven S , Goldstein Ellie , Hayden Mary K , Kaye Keith S , Potoski Brian A , Rodríguez-Baño Jesús , Sawyer Robert , Skalweit Marion , Snydman David R , Tamma Pranita D , Pahlke Sarah , Donnelly Katelyn , Loveless Jennifer 
Published: July 2024

Abstract
This article is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America. In this guideline, the panel provides recommendations for obtaining blood cultures in patients with known or suspected intra-abdominal infection. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.
Making a Pathogen? Evaluating the Impact of Protist Predation on the Evolution of Virulence in Serratia marcescens
Authors: Hopkins Heather A , Lopezguerra Christian , Lau Meng-Jia , Raymann Kasie 
Published: July 2024

Abstract
Opportunistic pathogens are environmental microbes that are generally harmless and only occasionally cause disease. Unlike obligate pathogens, the growth and survival of opportunistic pathogens do not rely on host infection or transmission. Their versatile lifestyles make it challenging to decipher how and why virulence has evolved in opportunistic pathogens. The coincidental evolution hypothesis postulates that virulence results from exaptation or pleiotropy, i.e. traits evolved for adaptation to living in one environment that have a different function in another. In particular, adaptation to avoid or survive protist predation has been suggested to contribute to the evolution of bacterial virulence (the training ground hypothesis). Here, we used experimental evolution to determine how the selective pressure imposed by a protist predator impacts the virulence and fitness of a ubiquitous environmental opportunistic bacterial pathogen that has acquired multidrug resistance: Serratia marcescens. To this aim, we evolved S. marcescens in the presence or absence of generalist protist predator, Tetrahymena thermophila. After 60 d of evolution, we evaluated genotypic and phenotypic changes by comparing evolved S. marcescens with the ancestral strain. Whole-genome shotgun sequencing of the entire evolved populations and individual isolates revealed numerous cases of parallel evolution, many more than statistically expected by chance, in genes associated with virulence. Our phenotypic assays suggested that evolution in the presence of a predator maintained virulence, whereas evolution in the absence of a predator resulted in attenuated virulence. We also found a significant correlation between virulence, biofilm formation, growth, and grazing resistance. Overall, our results provide evidence that bacterial virulence and virulence-related traits are maintained by selective pressures imposed by protist predation.
Assessment of unmeasured confounding in the association between perceived discrimination and mental health in a predominantly African American cohort using g-estimation
Authors: Luo Jiajun , Saulsberry Loren , Krakowka William Isaac , Ahsan Habibul , Aschebrook-Kilfoy Briseis 
Published: July 2024

Abstract

Background
Perceived discrimination in health care settings can have adverse consequences on mental health in minority groups. However, the association between perceived discrimination and mental health is prone to unmeasured confounding. The study aims to quantitatively evaluate the influence of unmeasured confounding in this association, using g-estimation.

Methods
In a predominantly African American cohort, we applied g-estimation to estimate the association between perceived discrimination and mental health, adjusted and unadjusted for measured confounders. Mental health was measured using clinical diagnoses of anxiety, depression and bipolar disorder. Perceived discrimination was measured as the number of patient-reported discrimination events in health care settings. Measured confounders included demographic, socioeconomic, residential and health characteristics. The influence of confounding was denoted as α1 from g-estimation. We compared α1 for measured and unmeasured confounding.

Results
Strong associations between perceived discrimination in health care settings and mental health outcomes were observed. For anxiety, the odds ratio (95% confidence interval) unadjusted and adjusted for measured confounders were 1.30 (1.21, 1.39) and 1.26 (1.17, 1.36), respectively. The α1 for measured confounding was –0.066. Unmeasured confounding with α1=0.200, which was over three times that of measured confounding, corresponds to an odds ratio of 1.12 (1.01, 1.24). Similar results were observed for other mental health outcomes.

Conclusion
Compared with measured confounding, unmeasured that was three times measured confounding was not enough to explain away the association between perceived discrimination and mental health, suggesting that this association is robust to unmeasured confounding. This study provides a novel framework to quantitatively evaluate unmeasured confounding.
The Simplicial Coalgebra of Chains Under Three Different Notions of Weak Equivalence
Authors: Raptis George , Rivera Manuel 
Published: July 2024

Abstract
We study the simplicial coalgebra of chains on a simplicial set with respect to three notions of weak equivalence. To this end, we construct three model structures on the category of reduced simplicial sets for any commutative ring $R$. The weak equivalences are given by: (1) an $R$-linearized version of categorical equivalences, (2) maps inducing an isomorphism on fundamental groups and an $R$-homology equivalence between universal covers, and (3) $R$-homology equivalences. Analogously, for any field ${\mathbb{F}}$, we construct three model structures on the category of connected simplicial cocommutative ${\mathbb{F}}$-coalgebras. The weak equivalences in this context are (1′) maps inducing a quasi-isomorphism of dg algebras after applying the cobar functor, (2′) maps inducing a quasi-isomorphism of dg algebras after applying a localized version of the cobar functor, and (3′) quasi-isomorphisms. Building on a previous work of Goerss in the context of (3)–(3′), we prove that, when ${\mathbb{F}}$ is algebraically closed, the simplicial ${\mathbb{F}}$-coalgebra of chains defines a homotopically full and faithful left Quillen functor for each one of these pairs of model categories. More generally, when ${\mathbb{F}}$ is a perfect field, we compare the three pairs of model categories in terms of suitable notions of homotopy fixed points with respect to the absolute Galois group of ${\mathbb{F}}$.
Laboratory capacity expansion: lessons from establishing molecular testing in regional referral laboratories in Ethiopia
Authors: Chekol Leulseged , Waktola Ebba , Nawaz Saira , Tadesse Lehageru , Muluye Samuel , Bonger Zelalem , Bogale Addisu , Eshetu Frehywot , Degefaw Desalegne , Tayachew Adamu , Delelegn Hulemenaw , Daves Sharon , Seyoum Eyasu , Moon Kyle , Melese Daniel , Balada Joan-Miquel , Wang Shu-Hua , Williams Desmond , Gebreyes Wondwossen , Mekuria Zelalem 
Published: July 2024

Abstract
Respiratory viruses contribute to high morbidity and mortality in Africa. In 2020, the Ohio State University's Global One Health Initiative, in collaboration with the Ethiopian Public Health Institute and the US Centers for Disease Control and Prevention, took action to strengthen Ethiopia's existing respiratory virus surveillance system through decentralization of laboratory testing and scale-up of national and regional capacity for detecting respiratory viruses. In August 2022, four regional laboratories were established, thereby raising the number of reference laboratories conducting respiratory virus surveillance to five. This article highlights lessons learned during implementation and outlines processes undertaken for laboratory scale-up and decentralization.