bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated Aging, Decreased White Matter Integrity, and Associated Neuropsychological Dysfunction 25 Years After Pediatric Lymphoid Malignancies
Authors: Schuitema Ilse , Deprez Sabine , Van Hecke Wim , Daams Marita , Uyttebroeck Anne , Sunaert Stefan , Barkhof Frederik , van Dulmen-den Broeder Eline , van der Pal Helena J. , van den Bos Cor , Veerman Anjo J.P. , de Sonneville Leo M.J. 
Published: August 2013

PurposeCNS-directed chemotherapy (CT) and cranial radiotherapy (CRT) for childhood acute lymphoblastic leukemia or lymphoma have various neurotoxic properties. This study aimed to assess their impact on the maturing brain 20 to 30 years after diagnosis, providing a much stronger perspective on long-term quality of life than previous studies.Patients and MethodsNinety-three patients treated between 1978 and 1990 at various intensities, with and without CRT, and 49 healthy controls were assessed with magnetic resonance diffusion tensor imaging (DTI) and neuropsychological tests. Differences in fractional anisotropy (FA)—a DTI measure describing white matter (WM) microstructure—were analyzed by using whole brain voxel-based analysis.ResultsCRT-treated survivors demonstrated significantly decreased FA compared with controls in frontal, parietal, and temporal WM tracts. Trends for lower FA were seen in the CT-treated survivors. Decreases in FA correlated well with neuropsychological dysfunction. In contrast to the CT group and controls, the CRT group showed a steep decline of FA with age at assessment. Younger age at cranial irradiation and higher dosage were associated with worse outcome of WM integrity.ConclusionCRT-treated survivors show decreased WM integrity reflected by significantly decreased FA and associated neuropsychological dysfunction 25 years after treatment, although effects of CT alone seem mild. Accelerated aging of the brain and increased risk of early onset dementia are suspected after CRT, but not after CT.
How Do Social Factors Explain Outcomes in Non–Small-Cell Lung Cancer Among Hispanics in California? Explaining the Hispanic Paradox
Authors: Patel Manali I. , Schupp Clayton W. , Gomez Scarlett L. , Chang Ellen T. , Wakelee Heather A. 
Published: August 2013

PurposeHispanics in the United States have lower age-adjusted mortality resulting from non–small-cell lung cancer (NSCLC) compared with non-Hispanic whites (NHWs). The purpose of this study was to evaluate individual, clinical, and neighborhood factors in survival among Hispanics with NSCLC.Patients and MethodsWe performed a retrospective analysis of NHWs and Hispanics with NSCLC between 1998 and 2007 in the California Cancer Registry (follow-up to December 2009). Kaplan-Meier curves depict survival by nativity for Hispanics with NSCLC. Cox proportional hazards models estimated hazard of mortality by race with adjustment for individual (age, sex, marital status), clinical (histologic grade, surgery, irradiation, chemotherapy), and neighborhood factors (neighborhood socioeconomic status, ethnic enclave).ResultsWe included 14,280 Hispanic patients with NSCLC. Foreign-born Hispanics had 15% decreased risk of disease-specific mortality resulting from NSCLC compared with NHWs (hazard ratio [HR], 0.85; 95% CI, 0.83 to 0.88) after adjustment for individual, clinical, and neighborhood factors. After adjustment for individual factors, compared with US-born Hispanics, foreign-born Hispanics had 10% decreased risk of disease-specific mortality (HR, 0.90; 95% CI, 0.87 to 0.96). Clinical and neighborhood factors slightly moderated the survival benefit for foreign-born patients. A modestly more pronounced survival advantage was seen for foreign-born Hispanics living in low socioeconomic and high Hispanic enclave neighborhoods as compared with US-born Hispanics (HR, 0.86; 95% CI, 0.81 to 0.90).ConclusionForeign-born Hispanics with NSCLC have a decreased risk of disease-specific mortality compared with NHWs and US-born Hispanics with NSCLC. Neighborhood factors slightly moderate this survival advantage. This survival advantage is slightly more pronounced in lower socioeconomic and higher Hispanic enclave neighborhoods.
Onshore and Offshore Hedge Funds: Are They Twins?
Authors: Aragon George , Liang Bing , Park Hyuna 
Published: August 2013

Contrary to offshore hedge funds, U.S.-domiciled (“onshore”) funds are subject to strict marketing prohibitions, accredited investor requirements, a limited number of investors, and taxable accounts. We exploit these differences to test predictions about organizational design, investment strategy, capital flows, and fund performance. We find that onshore funds are associated with greater share restrictions, more liquid assets, and a reduced sensitivity of capital flows to superior past performance. We also find some evidence that onshore funds outperform offshore funds, depending on the sample period. The results suggest that a fund's investment and financial policies reflect differences in investor clienteles and the regulatory environment. This paper was accepted by Wei Xiong, finance.
Optimal Software Reuse in Incremental Software Development: A Transfer Pricing Approach
Authors: Ceran Yasin , Dawande Milind , Liu Dengpan , Mookerjee Vijay 
Published: August 2013

This study develops optimal transfer pricing schemes that manage software reuse in incremental software development, namely, a development regime wherein users begin utilizing parts of the system that are released to them even before the system is entirely completed. In this setting, conflicts can arise between developers and users from divergent interests concerning the release of functionalities in the project. The release of functionalities is influenced by reuse, i.e., the effort spent by the development team to write code that can be reused within the same project or in future projects. For example, the development team may choose to spend extra effort to make certain portions of the system reusable because doing so could reduce the effort needed to develop the entire system. However, the additional effort spent on reuse could delay the release of certain critical functionality, making such a strategy suboptimal for the users. Thus, optimal reuse decisions for developers and users could be different. In addition, from the firm's perspective, reuse decisions must not only balance the objectives of developers and users for the current project, but reuse effort may be spent to benefit future projects. Our study also highlights the fact that reuse may not always be beneficial for the firm. To this end, we consider different instances of the user–developer conflict and provide transfer pricing schemes that operate under information asymmetry and achieve two key properties: firm-level optimality and truth revelation. This paper was accepted by Sandra Slaughter, information systems.
Identification of novel nucleus pulposus markers
Authors: Rodrigues-Pinto R. , Richardson S. M. , Hoyland J. A. 
Published: August 2013

Mesenchymal stem-cell based therapies have been proposed as novel treatments for intervertebral disc degeneration, a prevalent and disabling condition associated with back pain. The development of these treatment strategies, however, has been hindered by the incomplete understanding of the human nucleus pulposus phenotype and by an inaccurate interpretation and translation of animal to human research. This review summarises recent work characterising the nucleus pulposus phenotype in different animal models and in humans and integrates their findings with the anatomical and physiological differences between these species. Understanding this phenotype is paramount to guarantee that implanted cells restore the native functions of the intervertebral disc. Cite this article: Bone Joint Res 2013;2:169–78.
MicroRNA Signature Helps Distinguish Early from Late Biochemical Failure in Prostate Cancer
Authors: Lichner Zsuzsanna , Fendler Annika , Saleh Carol , Nasser Aurfan N , Boles Dina , Al-Haddad Sahar , Kupchak Peter , Dharsee Moyez , Nuin Paulo S , Evans Kenneth R , Jung Klaus , Stephan Carsten , Fleshner Neil E , Yousef George M 
Published: August 2013

PURPOSEProstate-specific antigen testing has led to overtreatment of prostate cancer (PCa). Only a small subset of PCa patients will have an aggressive disease that requires intensive therapy, and there is currently no biomarker to predict disease aggressiveness at the time of surgery. MicroRNAs (miRNAs) are reported to be involved in PCa pathogenesis.METHODSThis study involved 105 participants. For the discovery phase, prostatectomy samples were dichotomized to high-risk (n = 27, biochemical failure &lt;36 months after prostatectomy) and low-risk groups (n = 14, ≥36 months without biochemical failure). Expression of 754 mature miRNAs was compared between the 2 groups. Linear regression models were built to accurately predict biochemical failure risk. miRNA mimics were transfected into PCa model cell lines to test effects on proliferation and to deduce responding signaling pathways.RESULTSWe identified 25 differentially expressed miRNAs between the biochemical failure risk groups. Based on the expression of 2–3 miRNAs, 3 logistic regression models were developed, each with a high positive predictive value. Candidate miRNAs and the best-performing model were also verified on an independent PCa set. miRNA-152, featured in the models, was further investigated by using cell line models and was shown to affect cell proliferation. Predicted interaction between miR-152 and (mRNA)ERBB3 (erythroblastic leukemia viral oncogene homolog 3) was experimentally validated in vitro.CONCLUSIONSmiRNAs can help to predict biochemical failure risk at the time of prostatectomy.
Zahlen, Daten, Fakten – ein Forschungsinformationssystem als Grundlage des Qualitätsmanagements für die Forschung am Karlsruher Institut für Technologie (KIT)
Authors: Fondermann Philipp , Köppen Dominique 
Published: August 2013

Zusammenfassung
Der Beitrag zeigt zunächst, wie sehr ein Qualitätsmanagement-Regelkreis für die Forschung auf die Dokumentation von Forschungsinformationen mithilfe eines Forschungsinformationssystems (FIS) angewiesen ist. Nach einem Überblick über die generellen Einsatzmöglichkeiten dieser Systeme wird als Fallstudie das Projekt KIM-FIS vorgestellt, in dessen Rahmen die Bibliothek des Karlsruher Instituts für Technologie (KIT) derzeit ein Forschungsinformationssystem als Grundlage eines Qualitätsmanagements für die Forschung implementiert.
Surface Modification of Polyetheretherketone by Helium/nitrogen and Nitrous Oxide Plasma Enhanced Chemical Vapour Deposition
Authors: Kluska Stanisława , Pamuła Elżbieta , Jonas Stanisława , Grzesik Zbigniew 
Published: August 2013

AbstractThe surface of the polyetheretherketone (PEEK) samples was modified by the plasma enhanced chemical vapor deposition (PECVD) in the mixture of He and N2 as well as in the N2O atmosphere. Morphological characterization of the PEEK as well as its surface roughness, chemical structure, and surface free energy were investigated by atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and sessile drop technique, respectively. The highest increase in the polar component of the total surface energy was observed for PEEK modified by He+N2 plasma, which correlated with significant increase in the concentration of oxygen and nitrogen-containing chemical functionalities as revealed by XPS. For PEEK submitted to N2O plasma treatment significant changes in surface topography and increase in roughness were observed, but changes in surface chemistry and surface free energy were mild.
Reduction of FeO in EAF Steelmaking Slag by Blends of Metallurgical Coke and Waste Polypropylene
Authors: Dankwah James R. , Koshy Pramod 
Published: August 2013

AbstractThe reduction of FeO-containing slag by blends of metallurgical coke and waste polypropylene (PP) has been investigated through experiments conducted in a laboratory scale horizontal tube furnace. Composite pellets of EAF slag (47.1% FeO) with coke, PP and blends of coke/PP (in three different proportions) were rapidly heated at 1500 °C under high purity argon gas and the off gas was continuously analysed for CO and CO2 using an online infrared gas analyser (IR). The extent of reduction after fifteen minutes, level of carburisation and desulphurization were determined for each carbonaceous reductant. The results show that FeO can be effectively reduced from EAF slag to produce metallic iron using waste PP and its blends with coke as reductants; improvements in the extent of reduction and levels of carburisation and desulphurisation of the reduced metal were observed when coke was blended with PP.
Effects of Lanthanum and Boron on the Microstructure and Magnetic Properties of Non-oriented Electrical Steels
Authors: Wan Yong , Chen Wei-qing , Wu Shao-jie 
Published: August 2013

AbstractThe effects of lanthanum and boron on the inclusion size distribution, microstructure, texture and magnetic properties of three non-oriented electrical steels have been studied. After final annealing, lanthanum effectively inhibited the precipitation of MnS precipitates and promoted the growth of grains, an addition of 0.0041 wt.% boron led to the precipitation of Fe2B particles and inhibited grain growth. On the other hand, steel containing 0.0055 wt.% lanthanum had the strongest {100} and {111} fiber texture and the weakest {112}〈110〉 texture among the steels. Compared to steel without lanthanum and boron, steel with 0.0050 wt.% lanthanum and 0.0041 wt.% boron obtained slightly stronger intensities of {100} and {111} fiber texture, and a little weaker intensity of {112}〈110〉 texture. Steel containing 0.0055 wt.% lanthanum achieved the best magnetic properties, whose core loss and magnetic flux density were 4.268 W/kg and 1.768 T, respectively.
Bisphenol A and Chronic Disease Risk Factors in US Children
Authors: Eng Donna S. , Lee Joyce M. , Gebremariam Achamyeleh , Meeker John D. , Peterson Karen , Padmanabhan Vasantha 
Published: August 2013

OBJECTIVE:To evaluate the relationship between urinary bisphenol A (BPA) levels and measures of adiposity and chronic disease risk factors for a nationally representative US pediatric sample.METHODS:We used the NHANES 2003–2010 to evaluate cross-sectional associations between urinary BPA and multiple measures of adiposity, cholesterol, insulin, and glucose for children aged 6 to 18 years, adjusting for relevant covariates (eg, demographics, urine creatinine, tobacco exposure, and soda consumption).RESULTS:We found a higher odds of obesity (BMI ≥95th percentile) with increasing quartiles of BPA for quartiles 2 vs 1 (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.17–2.60, P = .008), 3 vs 1 (OR 1.64, 95% CI 1.09–2.47, P = .02), and 4 vs 1 (OR 2.01, 95% CI 1.36–2.98, P = .001). We also found a higher odds of having an abnormal waist circumference–to–height ratio (quartiles 2 vs 1 [OR 1.37, 95% CI 0.98–1.93, P = .07], 3 vs 1 [OR 1.41, 95% CI 1.07–1.87, P = .02], and 4 vs 1 [OR 1.55, 95% CI 1.12–2.15, P = .01]). We did not find significant associations of BPA with any other chronic disease risk factors.CONCLUSIONS:Higher levels of urinary BPA were associated with a higher odds of obesity (BMI &gt;95%) and abnormal waist circumference–to–height ratio. Longitudinal analyses are needed to elucidate temporal relationships between BPA exposure and the development of obesity and chronic disease risk factors in children.
Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials
Authors: Elazab Nancy , Mendy Angelico , Gasana Janvier , Vieira Edgar R. , Quizon Annabelle , Forno Erick 
Published: August 2013

BACKGROUND AND OBJECTIVE:
Probiotics may reduce the risk of atopy and asthma in children. However, results from clinical trials have been conflicting, and several of them may have been underpowered. We performed a meta-analysis of randomized, placebo-controlled trials to assess the effects of probiotic supplementation on atopic sensitization and asthma/wheeze prevention in children.

METHODS:
Random-effects models were used to calculate pooled risk estimates. Meta-regression was conducted to examine the effect of potential factors on probiotics efficacy.

RESULTS:
Probiotics were effective in reducing total immunoglobulin E (IgE) (mean reduction: –7.59 U/mL [95% confidence interval (CI): –14.96 to –0.22]; P = .044). Meta-regression showed that the reduction in IgE was more pronounced with longer follow-up. Probiotics significantly reduced the risk of atopic sensitization when administered prenatally (relative risk: 0.88 [95% CI: 0.78 to 0.99]; P = .035 for positive result on the skin prick test and/or elevated specific IgE to common allergens) and postnatally (relative risk: 0.86 [95% CI: 0.75 to 0.98]; P = .027 for positive result on skin prick test). Administration of Lactobacillus acidophilus, compared with other strains, was associated with an increased risk of atopic sensitization (P = .002). Probiotics did not significantly reduce asthma/wheeze (relative risk: 0.96 [95% CI: 0.85 to 1.07]).

CONCLUSIONS:
Prenatal and/or early-life probiotic administration reduces the risk of atopic sensitization and decreases the total IgE level in children but may not reduce the risk of asthma/wheeze. Follow-up duration and strain significantly modified these effects. Future trials for asthma prevention should carefully select probiotic strain and consider longer follow-up.
Use of a Computerized Decision Aid for ADHD Diagnosis: A Randomized Controlled Trial
Authors: Carroll Aaron E. , Bauer Nerissa S. , Dugan Tamara M. , Anand Vibha , Saha Chandan , Downs Stephen M. 
Published: August 2013

OBJECTIVE:
To determine if implementing attention-deficit/hyperactivity disorder (ADHD) diagnosis and treatment guidelines in a clinical decision support system would result in better care, including higher rates of adherence to clinical care guidelines.

METHODS:
We conducted a cluster randomized controlled trial in which we compared diagnosis and management of ADHD in 6- to 12-year-olds after implementation of a computer decision support system in 4 practices.

RESULTS:
Eighty-four charts were reviewed. In the control group, the use of structured diagnostic assessments dropped from 50% in the baseline period to 38% in the intervention period. In the intervention group, however, it rose from 60% to 81%. This difference was statistically significant, even after controlling for age, gender, and race (odds ratio of structured diagnostic assessment in intervention group versus control group = 8.0, 95% confidence interval 1.6–40.6). Significant differences were also seen in the number of ADHD core symptoms noted at the time of diagnosis. Our study was not powered to detect changes in care and management, but the percent of patients who had documented medication adjustments, mental health referrals, and visits to mental health specialists were higher in the intervention group than the control.

CONCLUSIONS:
The introduction of a clinical decision support module resulted in higher quality of care with respect to ADHD diagnosis including a prospect for higher quality of ADHD management in children. Future work will examine how to further develop the ADHD module and add support for other chronic conditions.
Unusual oxidation behavior of light metal hydride by tetrahydrofuran solvent molecules confined in ordered mesoporous carbon
Authors: Klose Markus , Lindemann Inge , Minella Christian Bonatto , Pinkert Katja , Zier Martin , Giebeler Lars , Nolis Pau , Baró Maria Dolors , Oswald Steffen , Gutfleisch Oliver , Ehrenberg Helmut , Eckert Jürgen 
Published: August 2013

Abstract
β-Catenin Mutation Status and Outcomes in Sporadic Desmoid Tumors
Authors: Mullen John T. , DeLaney Thomas F. , Rosenberg Andrew E. , Le Long , Iafrate A. John , Kobayashi Wendy , Szymonifka Jackie , Yeap Beow Y. , Chen Yen-Lin , Harmon David C. , Choy Edwin , Yoon Sam S. , Raskin Kevin A. , Hornicek Francis J. , Nielsen Gunnlauger P. 
Published: August 2013

Learning Objectives
Describe the frequency of CTNNB1 mutations in sporadic desmoid tumors. Summarize findings regarding CTNNB1 mutation status and disease outcome.
Laboratory Measurement of Sorption Isotherm Under Confining Stress With Pore-Volume Effects
Authors: Santos J.M.. M. , Akkutlu I.Y.. Y. 
Published: August 2013

Summary
For unconventional gas resources such as coal and organic-rich shale, sorbed phase is an important component of storage and transport calculations. Routine measurements of sorption are, however, performed separately from the porosity and permeability measurements. In this work, a new gas-storage measurement technique is proposed that combines the porosity and sorption measurements. Because the measurement is performed by use of core plugs under confining stress, it allows investigating the storage capacity for varying effective stress and incorporating the storage data into a subsequent permeability measurement under the same conditions.
During the construction of the sorption isotherm in the laboratory with the volumetric (gas expansion) method, at each pressure step, the sorbed gas taken up by the sample reduces the pore volume (PV) of the sample. As a result, the initially determined PV at low pressure must be corrected at the beginning and at the end of the pressure step. This correction can be performed relatively easily during the routine sorption measurements with the crushed samples; however, it is a challenging task with core plugs under confining stress because at each pressure step the PV could also change as a result of pore compressibility. Our approach is based on a new analytical model of total gas storability developed to interpret the measured multiple-step pressure data on a graphical domain in which the storage-parameter estimation can be performed fast and accurately with a straight line. The approach considers both the compressibility and the sorbed-phase effects on the porosity and the sorption parameters.
Experimental storage data of shale and coal samples with varying total organic content (TOC) and maturity are used to demonstrate the applicability of the analytical method to the measurements. The results show that the sorption measurements can be performed with increased accuracy and relatively fast. The work is important for organic-rich sample characterization in the laboratory, and for gas-in-place and transport calculations.