bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS NILAI-NILAI MORAL PADA NOVEL BIDADARI-BIDADARI SURGA KARYA TERE LIYE
Authors: . Chica , Landa Jumiati , . Kamal , . Saifullah 
Published: August 2024

Tujuan penelitian ini adalah untuk mendeskripsikan nilai-nilai moral yang terkandung dalam novel tersebut serta untuk mengetahui strategi pengarang menyampaikan nilai-nilai moral dalam karyanya. Penelitian ini menggunakan metode deskriptif kualitatif. Data pada penelitian ini yaitu teks yang mengandung nilai moral pada novel Bidadari-Bidadari Surga karya Tere Liye. Sumber data pada penelitian ini ada dua, yaitu sumber data primer dan sumber data sekunder. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah teknik baca dan teknik catat. Prosedur yang digunakan untuk menganalisis data yang dikumpulkan menggunakan model penelitian Miles dan Huberman yaitu reduksi data, penyajian data, dan kesimpulan/verifikasi. Hasil yang diperoleh dalam penelitian ini yaitu ditemukan empat bentuk nilai moral yang sesuai dengan teori Rachels, di antaranya nilai moral keberanian sebanyak bentuk 11, nilai moral kemurahan hati sebanyak 8, nilai moral kejujuran sebanyak 6 dan nilai moral kesetiaan kepada keluarga sebanyak 39. Berdasarkan temuan tersebut, penggunaan nilai moral yang paling dominan adalah nilai moral kesetiaan. Diketahui penulis Tere Liye banyak menulis karya sastra novel yang banyak berkaitan dengan keluarga. Hal ini dapat berimplikasi terhadap pembaca dengan memperoleh gambaran tentang nilai-nilai yang terkandung dalam setiap karyanya terkhusus nilai moral kesetiaan yang terdapat dalam novel Bidadari-Bidadari Surga karya Tere Liye.
Pelatihan Pengelolaan Keuangan untuk Keluarga : Mengelola Resiko dan Cerdas Finansial
Authors: Saragih Susanti , Widiastuti Ratna , Zaniarti Sri , Margaretha Yolla , Kristine Fanny , Nursalin Kezia Kurniawati , Margaretha Meily , Lu Cen 
Published: August 2024

This community service activity aims to increase the knowledge and skills of parents of Bandung Baptist Christian Junior High School students regarding families' financial planning and management to avoid family financial risk. This community service implementation method uses training with 25 participants, who are parents of students. The evaluation of this community service activity was carried out by conducting a survey to measure the reaction of participants, their knowledge level, and their change intention. Descriptive analysis was performed on the data collected. The results of the community service activity showed that more than 96% of the participants who attended found the activity relevant to their conditions. Additionally, 62% of the participants experienced an increase in knowledge regarding the concept of financial management, and all participants committed to taking concrete actions to improve their family's financial conditions, including avoiding debt, making financial records, using an application to simplify financial management, and setting a budget (financial prioritization).
Promoting the "Cempaka Tegal Slumpring Market" Tourism Through E-Tourism : Benchmarking Approach
Authors: Mubarok Abdulloh , Gashimov Elchin , Rahmatika Dien Noviany , Gashimov Denis , Susilawati Agnes Dwita , Amalia Mei Rani , Firmansyah Fahmi , Hapsari Yustia , Prasetyono Agus 
Published: August 2024

This community service aims to socialize the concept of digital promotion to introduce the Cempaka Tegal tourist village to the community in a wider area, both locally, nationally and internationally. The method of implementing this service uses socialization and benchmarking. Data collection was carried out through observation and interviews which were then analyzed descriptively. The results of this activity showed that the practice of implementing digital promotion of tourist attractions in the Samara province of Moscow, Russia can be applied to introduce Cempaka Tegal Slumpring Market Tourism to all corners of the world. The digital promotional practices include creating official websites for tourist attractions, utilizing social media such as Facebook, Instagram, and Twitter, utilizing virtual and augmented reality (VR/AR) technology, collaborating with influencers and travel bloggers, optimizing search engines (SEO) and provide a tourist village tourism application. Some of these promotional media have now been implemented, such as Facebook (Desa Wisata Cempaka, n.d.), Instagram (instagram.com/explore/locations/351643408686716/), collaboration with travel bloggers (Agus Fadilah, n.d.).
Ecoprint-Preneurship : Strategies for Local Economic Development and Sustainable Tourism Through Ecoprint Training
Authors: Rahmaningtyas Wisudani , Widhiastuti Ratieh , Purasani Hana Netti , Apriliana Shalum Rizki 
Published: August 2024

This service program aims to educate the community about the ecoprint method, an environmentally friendly printing technique that uses natural materials, such as local plant leaves, to create value-added products. The service method includes counseling, skill development, as well as lectures, practice, mentoring, monitoring, and evaluation. The data analysis used is descriptive analysis. The results of this service activity are increased community knowledge and skills in optimally utilizing natural potential and supporting sustainable economic development in Nyatnyono Village. Evaluation results showed high satisfaction with the relevance of the material, clarity of presentation, team responsiveness, and resource availability, although areas for improvement included language clarity, presentation structure, and ensuring adequate time for skill mastery. Overall, the community service activity had a significant positive impact on enhancing technical skills and creating new economic opportunities for the community.
Analisis Pemanfaatan APBD Kota Yogyakarta dalam Pengembangan Aplikasi Jogja Smart Service: Studi Kualitatif Deskriptif
Authors: Anggrayni Irena , Devandra Marsheila Hera 
Published: August 2024

Dalam penelitian ini akan lebih mengulik bagaimana pengalokasian dana APBD serta bentuk ilmpementasi yang dilakukan DISKOMINFOSAN dalam pemanfaatan aplikasi Jogja Smart Service. Penelitian ini menggunakan metode deskriptif kualitatif dengan teknik pengumpulan data melalui observasi, wawancara dan dokumentasi dengan menggunakan teori yang dikemukakan oleh Indrajit menyebutkan bahwa ada 3 elemen sukses dalam pengembangan E-Government berdasarkan kajian yang dilakukan oleh Harvard JFK School Of Government dengan memfokuskan pada elemen dukungan, elemen kapasitas dan elemen nilai (Indrajit, 2001) dengan 3 elemen antara lain: elemen pendukung, elemen kapasistas dan elemen nilai. Hasil penelitian menunjukan bahwasannya dalam pengalokasian dana APBD Kota Yogyakarta mulai dari tahun anggaran 2019 sebesar Rp. 2.260.970.585 sampai tahun 2023 sebesar Rp. 43.079.079.458 sudah terimplementasi dengan baik berdasar pada elemen pendukung yaitu pemerintah dengan pengesahan peraturan tentang digitalisasi pemerintah, kemudan elemen kapasitas berkaitan dengan finansial (dukungan APBD), fasilitas (jaringan wifi dan perangkat lunak) dan sumber daya manusia. Sehingga aplikasi JSS ini dapat digunakan oleh masyarakat secara mudah dan cepat, aplikasi JSS ini pula dalam implemntasinya mendapat penghargaan antara lain: top inovasi pelayanan pelayanan publik nasional dmana JSS ini masuk dalam top 45 inovasi pelayanan publik, JSS ini mewakili Indonesia dalam kompetensi layanan publik internasional masuk pada jajaran 11 nominasi United Nation of Public Service Award (UNPSA). Namun begitu masih ada saya kekurangan yang terjadi sepertin kendala jaringan, sosialisasi serta perangkat yang kurang mumpuni.
Kata Kunci : Anggaran, Jogja Smart Service, Implementasi
Sex-specific alterations in the gut and lung microbiome of allergen-induced mice
Authors: Ekpruke Carolyn Damilola , Alford Rachel , Rousselle Dustin , Babayev Maksat , Sharma Shikha , Parker Erik , Davis Kyle , Hemmerich Christopher , Rusch Douglas B. , Silveyra Patricia 
Published: August 2024

IntroductionRecent evidence has demonstrated that the microbiome is a driver of the underlying pathophysiological mechanisms of respiratory disease. Studies have indicated that bacterial metabolites produced in the gut and lung can impact lung inflammation and immune cell activity, affecting disease pathology. Despite asthma being a disease with marked sex differences, experimental work linking microbiomes and asthma has not considered the sex variable.MethodsTo test the hypothesis that the lung and gut microbial composition impacts allergic lung inflammation in a sex-specific manner, we evaluated lung and gut microbiome alterations in a mouse model of allergic inflammation and assessed their association with lung function and inflammation phenotypes. For this, we exposed male and female adult C57BL/6J mice intranasally to 25 µg of a house dust mite extract mix (HDM) daily, or phosphate-buffered saline (PBS) as control, for 5 weeks (n = 4–6/group). DNA from fecal pellets collected before and after the 5-week treatment, and from lung tissue collected at endpoint, was extracted using the ZymoBIOMICS®-96 MagBead DNA Kit and analyzed to determine the 16S microbiome via Targeted Metagenomic Sequencing.ResultsThe HDM treatment induced a sex-specific allergic inflammation phenotype with significantly higher neutrophilia, lymphocytosis, inflammatory gene expression, and histopathological changes in females than males following exposure to HDM, but higher airway hyperresponsiveness (AHR) in males than females. In addition, sex-specific lung gene expression and associated pathways were identified HDM mix after challenge. These changes corresponded to sex-specific alterations in the gut microbiome, where the Firmicutes to Bacteroidetes ratio (F:B) was significantly reduced in fecal samples from only male mice after HDM challenge, and alpha diversity was increased in males, but decreased in females, after 5-weeks of HDM treatment.DiscussionOverall, our findings indicate that intranasal allergen challenge triggers sex-specific changes in both gut and lung microbiomes, and induces sex-specific lung inflammation, AHR, and lung inflammatory gene expression pathways, suggesting a contribution of the lung-gut axis in allergic airway disease.
Molecular characteristics and pathogenic mechanisms of KPC-3 producing hypervirulent carbapenem-resistant Klebsiella pneumoniae (ST23-K1)
Authors: Tu Yanye , Gao Hui , Zhao Rongqing , Yan Jiliang , Wu Xingbing 
Published: August 2024

ObjectiveThis study aimed to comprehensively investigate hypervirulent carbapenem-resistant Klebsiella pneumoniae (CR-hvKP) in the Ningbo region. Importantly, we sought to elucidate its molecular characteristics and pathogenic mechanisms. This information will provide evidence-based insights for preventing and controlling nosocomial infections and facilitate improved clinical diagnosis and treatment in this region. Methods96 carbapenem-resistant Klebsiella pneumoniae strains were collected from the Ningbo region between January 2021 and December 2022. Whole genome sequencing and bioinformatic methods were employed to identify and characterize CR-hvKP strains at the molecular level. The minimum inhibitory concentrations (MICs) of common clinical antibiotics were determined using the VITEK-2 Compact automatic microbiological analyzer. Plasmid conjugation experiments evaluated the transferability of resistance plasmids. Finally, mouse virulence assays were conducted to explore the pathogenic mechanisms.ResultsAmong the 96 strains, a single CR-hvKP strain, designated CR-hvKP57, was identified, with an isolation frequency of 1.04%. Whole-genome sequencing revealed the strain to be ST23 serotype with a K1 capsule. This strain harbored three plasmids. Plasmid 1, a pLVPK-like virulence plasmid, carried multiple virulence genes, including rmpA, rmpA2, iroB, iucA, and terB. Plasmid 2 contained transposable element sequences such as IS15 and IS26. Plasmid 3, classified as a resistance plasmid, harbored the blaKPC-3 carbapenem resistance gene. Mouse virulence assays demonstrated a high mortality rate associated with CR-hvKP57 infection. Additionally, there was a significant increase in IL-1β, IL-6, and TNF-α levels in response to CR-hvKP57 infection, indicating varying degrees of inflammatory response. Western blot experiments further suggested that the pathogenic mechanism involves activation of the NF-κB signaling pathway.ConclusionThis study confirms the emergence of hypervirulent CR-hvKP in the Ningbo region, which likely resulted from the acquisition of a pLVPK-like virulence plasmid and a blaKPC-3 resistance plasmid by the ST23-K1 type Klebsiella pneumoniae. Our findings highlight the urgent need for more judicious use of antibiotics to limit the emergence of resistance. Additionally, strengthening infection prevention and control measures is crucial to minimize the spread of virulence and resistance plasmids.
An in-depth study on survival mechanism of bacterial isolates in disinfectants within the hospital environment
Authors: Rakshit Pue , Singh Aradhana , Singh Ravindra , Banerjee Tuhina 
Published: August 2024

IntroductionThe emergence of disinfectant resistance has become a severe threat due to reduced effectiveness. This study was undertaken to determine how bacteria adapt to survive exposure to disinfectants in the busiest section of a tertiary care hospital in Varanasi, India.MethodsFour isolates (two Klebsiella pneumoniae, Kp1 and Kp2; two Pseudomonas aeruginosa, Pa1 and Pa2) were obtained from chlorhexidine (CHX)–based handwash during microbiological surveillance of “in-use disinfectants” in hospital. Six disinfectants [4% CHX, 2% glutaraldehyde, 7.5% hydrogen peroxide, 1% sodium hypochlorite and 0.1% benzalkonium chloride (BAC), and 70% ethyl alcohol] were tested against these four isolates to determine minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Antibiotic profile, change in MIC on exposure to disinfectants and biofilm formation in the presence and absence of disinfectants was studied. Whole genome sequencing (WGS) was done to identify the resistance mechanisms.ResultThe isolates showed the highest MBC/MIC ratio (4) against glutaraldehyde. Exposure to supra-inhibitory concentration of BAC for 21 days resulted in doubling of MIC/MBC. The majority (75%) of the isolates were multidrug resistant. All the isolates were strong biofilm producers. The reduction rate of biofilm formation decreased with an increase in the concentration of disinfectants (p = 0.05 for BAC). WGS revealed multiple AMR genes including blaDIM-1, disinfectant-resistant gene and efflux pump genes.ConclusionThe study emphasized the various adaptation strategies of these isolates for survival in disinfectant environment, thus posing a huge challenge for their control in the hospital environment.
Cognitive function, mood and sleep changes in response to a Tai Chi/Qigong intervention among older breast cancer survivors: an exploratory analysis
Authors: James Dara L. , Maxfield Molly , Han SeungYong , Hawley Nanako A. , Petrov Megan E. , Sears Dorothy D. , Vance David E. , Larkey Linda K. 
Published: August 2024

IntroductionCognitive decline is a significant, persistent issue among breast cancer survivors (BCSs) affecting more than 50% and greatly impacting health and wellbeing, particularly among those who are aging. Scalable, lifestyle interventions to mitigate cognitive decline in this population are needed. This study aimed to explore the effects of Tai Chi Easy (TCE) on perceived cognition function among older BCSs.MethodsThe current work was part of a larger NCI-funded trial (R01CA182901, primary results reported elsewhere). Female BCSs, aged 45–75 years, were randomized to one of three conditions: two active interventions, Tai Chi Easy (TCE) or sham Qigong (SQG), or an education control group (EDC). In this exploratory analysis of older female participants (aged 60–75y), perceived cognitive function and performance and related factors (including anxiety, depression, and insomnia symptom severity) were examined. We anticipated TCE and SQG would show greater improvements in perceived cognitive function and performance compared to EDC.ResultsA total of 75 female BCS were included in the analysis (TCE = 23; SQG = 22; EDC = 30). Linear mixed model results showed BCS randomized to TCE and SQG reported improvements in perceived cognitive impairment and cognition-related effects on quality of life relative to EDC (with small to medium effect sizes; Cohen's d = 0.46 and 0.76), whereas no results were found for cognitive performance measures. Relative to EDC, TCE did not exact changes in depression, anxiety, and insomnia symptom severity; however, SQG showed decreases in depression and insomnia symptom severity (with corresponding small to medium effect sizes, Cohen's d = −0.36 and −0.56).DiscussionFindings from the current exploratory study suggest that low-exertion, gentle exercise, with or without breath and meditative focus, may improve perceived cognitive function, and, that without breath and meditative focus, may improve depressed mood and insomnia symptoms among older BCS. These promising findings may have immediate and long-term implications on accessible treatment options recommended by geriatricians and oncologists treating older BCS at an elevated risk for cognitive impairment.Clinical trial registrationThe parent study was registered on ClinicalTrials.gov, identifier: NCT02690116.
Safety and efficacy of aspirin and indobufen in the treatment of coronary heart disease: a systematic review and meta-analysis
Authors: Zhang Xiaochen , Yan Qiaoyan , Jiang Jiao , Luo Hua , Ren Yu 
Published: August 2024

PurposeThis meta-analysis aimed to compare the safety and efficacy of aspirin and indobufen in patients with coronary heart disease. The primary focus was on the incidence of cardiovascular events, bleeding events, and gastrointestinal reactions. Given the relatively limited research on indobufen, this study utilized aspirin as a control drug and employed meta-analysis to integrate existing clinical studies. The goal was to provide a reference for the clinical use of indobufen and to suggest directions for further largescale, multicenter prospective studies.MethodsThis review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We conducted a comprehensive search of the PubMed, EMBASE, WOS, and Cochrane Library databases to identify all relevant literature on indobufen. A total of nine trials met the inclusion criteria, encompassing seven randomized controlled trails (RCTs) and two retrospective studies. Categorical variables were analyzed using odds ratio and random effects models.ResultsThe meta-analysis included nine trials, comprising seven RCTs and two retrospective studies. The pooled results indicated that indobufen significantly reduced the incidence of minor bleeding events, and gastrointestinal discomfort compared to aspirin. However, both drugs had similar effects on the incidence of recurrent angina pectoris, myocardial infarction and mortality due to coronary heart disease.ConclusionIndobufen was associated with fewer gastrointestinal reactions and a low risk of bleeding, making it a viable option for patients with high-risk factors for bleeding and gastric ulcers. Despite this, indobufen's short history and limited evidence base compared to aspirin highlight the need for further research. Aspirin remains widely available, cost-effective, and the preferred drug for the primary and secondary prevention of cardiovascular and cerebrovascular diseases. Indobufen or other antiplatelet agents should only be considered when aspirin is not tolerated or contraindicated. Further clinical trials are necessary to determine whether indobufen can replace aspirin.Systematic Review Registrationhttps://www.crd.york.ac.uk/, identifier [CRD42024523477].
Framework for optimal energy storage duration for maximum-reliability renewable electricity
Authors: Sadhukhan Jhuma , Sen Sohum , Randriamahefasoa T. M. S. 
Published: August 2024

Energy system optimization is needed for optimal sustainable net-zero electricity (NZE) mix even at regional/local scales because of the energy storage needs for addressing the intermittency of renewable energy supply. This study presents a novel regional/local energy planning model for optimum sustainable NZE mix under spatiotemporal climate/meteorological and electrical load demand constraints. A generic robust non-linear constrained mathematical programming (NLP) algorithm has been developed for energy system optimization; it minimizes the levelized cost and greenhouse gas emissions while maximizing reliability against stored energy discharge analysis (RADA). Reliability, defined as the ratio of excess stored renewable power discharge to unmet load demand, is a measure of the extent of unmet load demand met by the excess stored renewable power. Coupled with the NLP, the RADA and energy storage evaluations are used to determine the seasonal energy storage (SES) conditions and realistic renewable proportions for NZE. The significance of the proposed framework lies in determining the maximum hours of viable electrical energy storage beyond which the reliability enhancement is infinitesimal. The significant observations of this work include 96 h of maximum viable electrical energy storage beyond which the reliability enhancement is infinitesimal. While this observation is robust based on previous reports for the case of the United States, a realistic NZE mix for Southern United Kingdom is obtained as follows. Direct wind and solar sources can meet 63%, 62%, and 55% of the electricity demands in the southwest, Greater London, and southeast regions of the United Kingdom, respectively; further, battery energy storage systems can increase the renewable proportions by 21%, 22%, and 13% in these three regions. The unmet demands can be met by renewable electricity through SES. Compressed air energy storage (CAES) and pumped hydro storage offer viable SES. Following these, natural gas with carbon capture and storage (CCS), bioenergy, and hydrogen SES are the choices based on increasing cost per lifecycle climate impact potential to meet the electricity demands.
Identification and validation of Rab GTPases RAB13 as biomarkers for peritoneal metastasis and immune cell infiltration in colorectal cancer patients
Authors: Lv Fei , Li Xiaoqi , Wang Zhe , Wang Xiaobo , Liu Jing 
Published: August 2024

BackgroundAs one of the most common cancer, colorectal cancer (CRC) is with high morbidity and mortality. Peritoneal metastasis (PM) is a fatal state of CRC, and few patients may benefit from traditional therapies. There is a complex interaction between PM and immune cell infiltration. Therefore, we aimed to determine biomarkers associated with colorectal cancer peritoneal metastasis (CRCPM) and their relationship with immune cell infiltration.MethodsBy informatic analysis, differently expressed genes (DEGs) were selected and hub genes were screened out. RAB13, one of the hub genes, was identificated from public databases and validated in CRC tissues. The ESTIMATE, CEBERSORT and TIMER algorithms were applied to analyze the correlation between RAB13 and immune infiltration in CRC. RAB13’s expression in different cells were analyzed at the single-cell level in scRNA-Seq. The Gene Set Enrichment Analysis (GSEA) was performed for RAB13 enrichment and further confirmed. Using oncoPredict algorithm, RAB13’s impact on drug sensitivity was evaluated.ResultsHigh RAB13 expression was identified in public databases and led to a poor prognosis. RAB13 was found to be positively correlated with the macrophages and other immune cells infiltration and from scRNA-Seq, RAB13 was found to be located in CRC cells and macrophages. GSEA revealed that high RAB13 expression enriched in a various of biological signaling, and oncoPredict algorithm showed that RAB13 expression was correlated with paclitaxel sensitivity.ConclusionOur study indicated clinical role of RAB13 in CRC-PM, suggesting its potential as a therapeutic target in the future.