bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediation of Clathrin-Dependent Trafficking during Cytokinesis and Cell Expansion by Arabidopsis STOMATAL CYTOKINESIS DEFECTIVE Proteins
Authors: McMichael Colleen M. , Reynolds Gregory D. , Koch Lisa M. , Wang Chao , Jiang Nan , Nadeau Jeanette , Sack Fred D. , Gelderman Max B. , Pan Jianwei , Bednarek Sebastian Y. 
Published: November 2013

Abstract
STOMATAL CYTOKINESIS DEFECTIVE1 (SCD1) encodes a putative Rab guanine nucleotide exchange factor that functions in membrane trafficking and is required for cytokinesis and cell expansion in Arabidopsis thaliana. Here, we show that the loss of SCD2 function disrupts cytokinesis and cell expansion and impairs fertility, phenotypes similar to those observed for scd1 mutants. Genetic and biochemical analyses showed that SCD1 function is dependent upon SCD2 and that together these proteins are required for plasma membrane internalization. Further specifying the role of these proteins in membrane trafficking, SCD1 and SCD2 proteins were found to be associated with isolated clathrin-coated vesicles and to colocalize with clathrin light chain at putative sites of endocytosis at the plasma membrane. Together, these data suggest that SCD1 and SCD2 function in clathrin-mediated membrane transport, including plasma membrane endocytosis, required for cytokinesis and cell expansion.
Crosstalk between the Unfolded Protein Response and Pathways That Regulate Pathogenic Development inUstilago maydis
Authors: Heimel Kai , Freitag Johannes , Hampel Martin , Ast Julia , Bölker Michael , Kämper Jörg 
Published: November 2013

AbstractThe unfolded protein response (UPR) is a conserved eukaryotic signaling pathway regulating endoplasmic reticulum (ER) homeostasis during ER stress, which results, for example, from an increased demand for protein secretion. Here, we characterize the homologs of the central UPR regulatory proteins Hac1 (for Homologous to ATF/CREB1) and Inositol Requiring Enzyme1 in the plant pathogenic fungus Ustilago maydis and demonstrate that the UPR is tightly interlinked with the b mating-type-dependent signaling pathway that regulates pathogenic development. Exact timing of UPR is required for virulence, since premature activation interferes with the b-dependent switch from budding to filamentous growth. In addition, we found crosstalk between UPR and the b target Clampless1 (Clp1), which is essential for cell cycle release and proliferation in planta. The unusual C-terminal extension of the U. maydis Hac1 homolog, Cib1 (for Clp1 interacting bZIP1), mediates direct interaction with Clp1. The interaction between Clp1 and Cib1 promotes stabilization of Clp1, resulting in enhanced ER stress tolerance that prevents deleterious UPR hyperactivation. Thus, the interaction between Cib1 and Clp1 constitutes a checkpoint to time developmental progression and increased secretion of effector proteins at the onset of biotrophic development. Crosstalk between UPR and the b mating-type regulated developmental program adapts ER homeostasis to the changing demands during biotrophy.
Digitization projects in university libraries in Nigeria: the journey so far
Authors: Emmanuel Baro Ebikabowei , Gboyega Oyeniran Kayode , Ateboh Benedict 
Published: November 2013

Purpose
– The purpose of this paper is to investigate digitization activities in university libraries in Nigeria and to identify the challenges encountered in their various digitization projects.

Design/methodology/approach
– Data collection for the study was in two phase. First, a telephone conversation with university librarians is to investigate whether they have adopted digitization of materials. Second, e-mail questionnaire was sent to the various university libraries into digitization projects.

Findings
– The study revealed that only few university libraries have adopted digitization of their information resources in Nigeria. The main aim of the digitization projects is to have greater access to local contents globally. However, the digitization projects are faced with challenges such as unstable internet connectivity, lack of fund, irregular power supply, collecting materials for digitization, lack of IT personnel, absence of digitization policy, and copyright issues. Ways to overcome the challenges were suggested such as provision of stable internet connectivity, installation of solar energy, purchase of giant generators, and training of staff.

Originality/value
– Findings from this study might be useful to university libraries in developing countries that are planning to go into digitization of information resources for global accessibility.
Physicochemical properties of fermented wheat-chickpea-rice weaning blend
Authors: M. Adhikari Bhaskar , Elizabeth Adelakun Oluyemisi , B. Katawal Surendra 
Published: November 2013

Purpose
– This paper aims to focus on the effect of fermentation on wheat-chickpea-rice weaning blend.

Design/methodology/approach
– Wheat, chickpea, and rice were blended and fermented with Rhizopus koji for 60 h at 29±2°C at an interval of 15 h. Blends were analyzed using methods reported in the literature for physicochemical and sensory properties.

Findings
– Protein content of the weaning blends increased progressively from 14.63 percent in the unfermented to 20.89 percent after 60 h of fermentation, while the fat content decreased as fermentation time increases. The pH of the samples gradually decreased from 4.53 to 3.83 with gradual increase in titratable acidity as fermentation time increases. The water absorption capacity, total plate count, and yeast and mold count were found to be in the range 112.2±1.16 to 171±1.67 percent, 1.0×103 to 1.3×103 cfu/g, and 700 to 800 cfu/g, respectively. In terms of sensory analysis, 15-h fermented sample was found to be the best.

Originality/value
– The paper has demonstrated effect of fermentation on wheat-chickpea-rice weaning blend.
Dietary and lifestyle habits among adolescent girls in Saudi Arabia
Authors: Obaid Musaiger Abdulrahman , Zagzoog Nisreen 
Published: November 2013

Purpose
– The main purpose of this study was to explore the differences in dietary habits and lifestyle between girls in government and private schools in Saudi Arabia.

Design/methodology/approach
– A cross-sectional multistage stratified survey was carried out on schoolgirls aged 12-19 years. The total sample was 512 girls (291 and 221 girls from government and private schools, respectively). A pretested questionnaire was used to collect the data.

Findings
– The findings revealed that girls in private schools were significantly more likely to consume vegetables, fruits, red meat, and chicken than those in government schools. Furthermore, private schoolgirls were less prone to watch television and use the internet daily than girls in government schools.

Originality/value
– Intervention for promoting healthy lifestyles in schoolchildren should not exclude private schools.
Making sense of liaison consultations: using reflection to understand information-seeking behavior
Authors: Suarez Doug 
Published: November 2013

Purpose
– The purpose of this paper is to reflect on past liaison library practice to make sense of student information-seeking behavior. Experiential data created from liaison consultations was used to gain student perspectives. Liaison consultations enhance student experiences and provide strategic benefits for academic libraries to counter perceived under-utilization of information services in general.

Design/methodology/approach
– Grounded theory framed the study and thematic analysis was applied to liaison librarian consultation notes representing 25 years of past practice. Themes that characterize information-seeking behaviors were noted and used to help explain student behavior.

Findings
– Despite significant changes in information formats, the pervasive use of internet technology, and student searching habits, the key finding is that students will continue to consult with librarians to the extent that they find the experience useful. Both parties contribute and define the reference consultation to help formulate productive information-seeking behaviors.

Originality/value
– Analyzing evidence through the lens of reflection and the use of unobtrusive methods provided useful insights into the roles that librarians and students play in the consultation process. The findings suggest that information-searching behaviors can be influenced and shaped to produce successful searching outcomes. Several recommendations for strengthening library practice are provided.
The Big Society and English public libraries: where are we now?
Authors: Goulding Anne 
Published: November 2013

Purpose
– The purpose of this paper is to analyse the impact of the Big Society on public libraries in England. It evaluates the conceptualisation of public libraries as agents in the Big Society agenda and explores the practical implications of this positioning.

Design/methodology/approach
– The author critically evaluates evidence from a range of literature, documentation and other sources on the topics of the Big Society, localism and public libraries, the majority of which is of English or UK origin, including that from academic journals, books, grey literature and web sites including blogs and discussion lists. Recent and current developments are reviewed and commented on from the author's viewpoint.

Findings
– The paper advances the view that although public libraries encapsulate many Big Society values, including community empowerment and social action, many local councils are seizing on Big Society rhetoric as an expedient method for driving through cutbacks and closures, rather than as a way of making a true shift of power from governors to the governed.

Originality/value
– The paper critically evaluates discourses surrounding public libraries and the Big Society with the aim of raising awareness of the local authority policy context and stimulating discussion of the future of public libraries in England.
Strategy essentials: organizational simulators
Authors: Páscoa Carlos , Ferreira Nelson , Tribolet José 
Published: November 2013

Purpose
– The aim of this article is to: provide an overview of the role of organizational simulators as essential tools to assess, at early stages of the planning phase, organizational objectives and strategy; propose recommendations on how to advance the subject area in terms of research and development; demonstrate that aeronautical concepts can be applied in the organizational context.

Design/methodology/approach
– The article refers concepts and theories related with the subject and presents a methodology for social investigation, which was used in this research.

Findings
– Organizational simulators have a fundamental role in organizational self-awareness because they help to control the organization's vital parameters, in a proactive manner, considering the creation of different scenarios that allow, beforehand, a predictive assessment.

Research limitations/implications
– The research provides empirical evidence of use in the operational domain of the Portuguese Air Force and also an example of the valuable collaboration between real operations use and academia research. It also offers an insight, by using the metaphor “Flying the Organization”, on how flying concepts can be applied in the organizational context.

Practical implications
– The research lab was done using Microsoft Excel in what was related to the simulator development. All relevant data was gathered from organization's information systems (IS) and inserted into Microsoft Excel. Future implementations should be integrated with the organization's IS.

Originality/value
– This article contributes to the “state of art” of organizational simulators by providing a real case and provides both the entrepreneurial and academia communities for conducting future actions within this subject. The article also provides value to organizational management actors on how organizational simulators can be applied.
Digital preservation cost: a cost accounting approach
Authors: Boté Juanjo , Fernandez-Feijoo Belen , Ruiz Silvia 
Published: November 2013

Purpose
– Digital preservation (DP) is the term used to describe the processes that guarantee the accessibility of data in the long term. The high value of health information justifies the use of electronic health records and the DP of them. This paper aims to examine one of the economic aspects of DP, presenting a cost model proposal for DP in health care organizations.

Design/methodology/approach
– Using a cost accounting methodology and beginning from the product and productive process definition, the authors propose a customized application of cost calculation to digital preservation for health data.

Findings
– This paper contributes to the existing literature with a cost model proposal to calculate the cost of DP applying a cost analysis methodology.

Research limitations/implications
– The authors present a cost model to the DP process in the health care field, with specific, concrete and limited kind of digital formats to be preserved. This can represent a limitation to this paper.

Practical implications
– Implementing a cost model of DP in hospital is a practical way to obtain basic information for making decisions regarding preservation.

Originality/value
– This paper sheds light on how to apply the methodology of one of the most traditional information systems, accounting, to one of the newest information systems, DP.
An e-marketplace of healthcare and social care services: the perceived interest
Authors: Manuela Cruz-Cunha Maria , Miranda Isabel , Lopes Nuno , Simoes Ricardo 
Published: November 2013

Purpose
– The health and social care sector is receiving growing attention due to the increased life expectancy and to the public demand for a better quality of life and better health services. New cost-efficient approaches are required, and the paper aims to present and discuss the main results of a study undertaken in a Portuguese municipality on the perceived relevance of an e-marketplace of social and healthcare services for the inhabitants in general, and for people with special needs in particular, and the identification of the most relevant services to be offered through this platform.

Design/methodology/approach
– A wide survey was undertaken to identify the needs of potential users and their expectancies with relation to the proposed platform. The results of the study are a support for the project promoters to understand the viability of the solution and the requirements to the deployment of the pilot experiment, as well as to drive the selection of domains of activities/classes of services to be offered by the platform.

Findings
– Services such as information about healthcare services, home monitoring/accompanying services 24 hours per day, and personal hygiene services provided at home are the ones recognized by the inquired citizens as the most important, which indicates that the potential users will be mostly people with special needs or their family or caregivers.

Originality/value
– While still at a preliminary development phase, the project represents a good opportunity to develop a totally innovative service with high potential impact for the senior population and for individuals with special needs.
Impact of placement type on the development of clinical competency in speech–language pathology students
Authors: Sheepway Lyndal , Lincoln Michelle , McAllister Sue 
Published: November 2013

AbstractBackgroundSpeech–language pathology students gain experience and clinical competency through clinical education placements. However, currently little empirical information exists regarding how competency develops. Existing research about the effectiveness of placement types and models in developing competency is generally descriptive and based on opinions and perceptions. The changing nature of education of speech–language pathology students, diverse student cohorts, and the crisis in finding sufficient clinical education placements mean that establishing the most effective and efficient methods for developing clinical competency in students is needed.AimsTo gather empirical information regarding the development of competence in speech–language pathology students; and to determine if growth of competency differs in groups of students completing placements that differ in terms of caseload, intensity and setting.Methods & ProceduresParticipants were students in the third year of a four‐year undergraduate speech–language pathology degree who completed three clinical placements across the year and were assessed with the COMPASS® competency assessment tool. Competency development for the whole group across the three placements is described. Growth of competency in groups of students completing different placement types is compared. Interval‐level data generated from the students’ COMPASS® results were subjected to parametric statistical analyses.Outcomes & ResultsThe whole group of students increased significantly in competency from placement to placement across different placement settings, intensities and client age groups. Groups completing child placements achieved significantly higher growth in competency when compared with the competency growth of students completing adult placements. Growth of competency was not significantly different for students experiencing different intensity of placements, or different placement settings.Conclusions & ImplicationsThese results confirm that the competency of speech–language pathology students develops across three clinical placements over a one‐year period regardless of placement type or context, indicating that there may be a transfer of learning between placements types. Further research investigating patterns of competency development in speech–language pathology students is warranted to ensure that assumptions used to design clinical learning opportunities are based on valid evidence.
Phonology in Swedish‐speaking 3‐year‐olds born with cleft lip and palate and the relationship with consonant production at 18 months
Authors: Klintö Kristina , Eva‐Kristina‐Salameh  , Olsson Maria , Flynn Traci , Svensson Henry , Lohmander Anette 
Published: November 2013

AbstractBackgroundApproximately 50% of children born with cleft palate present speech difficulties around 3 years of age, and several studies report on persisting phonological problems after palatal closure. However, studies on early phonology related to cleft palate are few and have so far mainly been carried out on English‐speaking children. Studies on phonology related to cleft palate in languages other than English are also warranted.AimsTo assess phonology in Swedish‐speaking children born with and without unilateral cleft lip and palate (UCLP) at 3 years of age, and to identify variables at 18 months that are associated with restricted phonology at age 3 years.Methods & ProceduresEighteen consecutive children born with UCLP and 20 children without cleft lip and palate were included. Transcriptions of audio recordings at 18 months and 3 years were used. Per cent correct consonants adjusted for age (PCC‐A), the number of established phonemes, and phonological simplification processes at 3 years were assessed and compared with different aspects of consonant inventory at 18 months.Outcomes & ResultsPCC‐A, the number of established phonemes, and the total number of phonological processes differed significantly at 3 years between the two groups. Total number of oral consonants, oral stops, dental/alveolar oral stops and number of different oral stops at 18 months correlated significantly with PCC‐A at 3 years in the UCLP group.Conclusions & ImplicationsAs a group, children born with UCLP displayed deviant phonology at 3 years compared with peers without cleft lip and palate. Measures of oral consonant and stop production at 18 months might be possible predictors for phonology at 3 years in children born with cleft palate.
Validation of the Thai version of the Health Assessment Questionnaire for patients with psoriatic arthritis
Authors: Katchamart Wanruchada , Benjamanukul Saovanee , Chiowchanwesawakit Praveena 
Published: November 2013

AbstractObjectiveTo validate the Thai version of the Health Assessment Questionnaire (HAQ) for patients with psoriatic arthritis (PsA).MethodsThe Thai version of the HAQ was administered to 47 patients with PsA attending our rheumatology clinic. Clinical assessments included the measures of disease activity, disease severity and functional status. The correlation of the single items and total score of the Thai HAQ with the measures of disease activity, disease severity and functional status was assessed using Pearson's correlation or Spearman rank correlation, as appropriate.ResultsOf 47 patients who fulfilled the Classification Criteria for Psoriatic Arthritis (CASPAR), 21 were male. Their mean age ± standard deviation (SD) and mean disease duration ± SD were 49 ± 10 years and 6.97 ± 6.17 years, respectively. Spondylitis was the most common manifestation (38%). The mean Thai HAQ score was 0.47. The single items and total score of the Thai HAQ were moderately to highly correlated with several measures of disease activity (r = 0.32–0.81, P < 0.01), except for swollen joint count (r = 0.16). For functional status and disease severity, the Thai HAQ was moderately correlated with grip strength (r = −0.39, P < 0.01), but poorly correlated with the range of spinal movement and the number of damaged joints. (r = −0.01 to 0.17). Cronbach's alpha coefficient for internal consistency reliability was 0.88. These results were comparable to the original version.ConclusionThe Thai version of the HAQ is valid for assessing functional status in patients with PsA; however, its validity may be limited in patients who have axial involvement or permanent joint damage.
Cerebral radiation necrosis
Authors: Na Angelika , Haghigi Neda , Drummond Katharine J 
Published: November 2013

AbstractCerebral radiation‐induced injury ranges from acute reversible edema to late irreversible radiation necrosis (RN). Cerebral RN is poorly responsive to treatment, is associated with permanent neurological deficits and occasionally progresses to death. We review the literature regarding cerebral RN after radiotherapy for various brain and head and neck lesions and discuss its clinical features, imaging characteristics, pathophysiology and treatment. For new enhancing lesions on computed tomography or magnetic resonance imaging, apart from tumor progression or recurrence, RN needs to be considered in the differential diagnosis. Further studies are required to design chemoradiotherapy protocols that are effective in treating tumors while minimizing risk of RN. Current available treatments for RN, steroid and surgery, only relieve the mass effect. None of the experimental treatments to date have consistently been shown to reverse the pathologic process of RN.
Safety and accuracy of core biopsy in retroperitoneal sarcomas
Authors: Hwang Sang Yun , Warrier Sanjay , Thompson Stephen , Davidson Trent , Yang Jia Lin , Crowe Philip 
Published: November 2013

AbstractAimRetroperitoneal sarcomas (RPSs) are large, rare tumors. The role of core biopsy for retroperitoneal masses identified by preoperative imaging is unclear and we report the safety and accuracy of core biopsies at a specialized sarcoma unit in Sydney, Australia.MethodsA retrospective analysis of a prospectively collected database was performed to identify the safety and accuracy of core biopsies in patients who were confirmed to have RPS.ResultsTwenty‐two patients underwent biopsies with no recorded morbidity or tumor seeding. RPS was correctly identified in 82%. Median follow‐up was 19 months.ConclusionWe demonstrate that core biopsy is safe and can identify RPSs.