bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of Bile Acid in Regulating Platelet Function and Thrombotic Diseases
Authors: Zhou Xianghui , Zhou Xin , Zhang Zhao , Zhu Ruirui , Lu Meng , Lv Keyu , Fang Chao , Ming Zhangyin , Cheng Zhipeng , Hu Yu 
Published: June 2024

AbstractPlatelets play a key role in physiological hemostasis and pathological thrombosis. Based on the limitations of current antiplatelet drugs, it's important to elucidate the mechanisms of regulating platelet activation. In addition to dissolving lipid nutrients, bile acids (BAs) can regulate platelet function. However, the specific mechanisms underlying BAs‐mediated effects on platelet activation and thrombotic diseases remain unknown. Therefore, the effects of BAs on platelets and intracellular regulatory mechanisms are explored. It is showed that the inhibitory effect of secondary BAs is more significant than that of primary BAs; lithocholic acid (LCA) shows the highest inhibitory effect. In the process of platelet activation, BAs suppress platelet activation via the spleen tyrosine kinase (SYK), protein kinase B (Akt), and extracellular signal‐regulated kinase1/2 (Erk1/2) pathways. Nck adaptor proteins (NCK1) deficiency significantly suppress the activity of platelets and arterial thrombosis. Phosphorylated proteomics reveal that LCA inhibited phosphorylation of syntaxin‐11 at S80/81 in platelets. Additional LCA supplementation attenuated atherosclerotic plaque development and reduced the inflammation in mice. In conclusion, BAs play key roles in platelet activation via Syk, Akt, ERK1/2, and syntaxin‐11 pathways, which are associated with NCK1. The anti‐platelet effects of BAs provide a theoretical basis for the prevention and therapy of thrombotic diseases.
Unsupervised Segmentation of 3D Microvascular Photoacoustic Images Using Deep Generative Learning
Authors: Sweeney Paul W. , Hacker Lina , Lefebvre Thierry L. , Brown Emma L. , Gröhl Janek , Bohndiek Sarah E. 
Published: June 2024

AbstractMesoscopic photoacoustic imaging (PAI) enables label‐free visualization of vascular networks in tissues with high contrast and resolution. Segmenting these networks from 3D PAI data and interpreting their physiological and pathological significance is crucial yet challenging due to the time‐consuming and error‐prone nature of current methods. Deep learning offers a potential solution; however, supervised analysis frameworks typically require human‐annotated ground‐truth labels. To address this, an unsupervised image‐to‐image translation deep learning model is introduced, the Vessel Segmentation Generative Adversarial Network (VAN‐GAN). VAN‐GAN integrates synthetic blood vessel networks that closely resemble real‐life anatomy into its training process and learns to replicate the underlying physics of the PAI system in order to learn how to segment vasculature from 3D photoacoustic images. Applied to a diverse range of in silico, in vitro, and in vivo data, including patient‐derived breast cancer xenograft models and 3D clinical angiograms, VAN‐GAN demonstrates its capability to facilitate accurate and unbiased segmentation of 3D vascular networks. By leveraging synthetic data, VAN‐GAN reduces the reliance on manual labeling, thus lowering the barrier to entry for high‐quality blood vessel segmentation (F1 score: VAN‐GAN vs. U‐Net = 0.84 vs. 0.87) and enhancing preclinical and clinical research into vascular structure and function.
In Situ Quantitative Monitoring of Adsorption from Aqueous Phase by UV–vis Spectroscopy: Implication for Understanding of Heterogeneous Processes
Authors: Yang Xu‐Dan , Gong Bo , Chen Wei , Chen Jie‐Jie , Qian Chen , Lu Rui , Min Yuan , Jiang Ting , Li Liang , Yu Han‐Qing 
Published: June 2024

AbstractThe development of in situ techniques to quantitatively characterize the heterogeneous reactions is essential for understanding physicochemical processes in aqueous phase. In this work, a new approach coupling in situ UV–vis spectroscopy with a two‐step algorithm strategy is developed to quantitatively monitor heterogeneous reactions in a compact closed‐loop incorporation. The algorithm involves the inverse adding‐doubling method for light scattering correction and the multivariate curve resolution‐alternating least squares (MCR‐ALS) method for spectral deconvolution. Innovatively, theoretical spectral simulations are employed to connect MCR‐ALS solutions with chemical molecular structural evolution without prior information for reference spectra. As a model case study, the aqueous adsorption kinetics of bisphenol A onto polyamide microparticles are successfully quantified in a one‐step UV–vis spectroscopic measurement. The practical applicability of this approach is confirmed by rapidly screening a superior adsorbent from commercial materials for antibiotic wastewater adsorption treatment. The demonstrated capabilities are expected to extend beyond monitoring adsorption systems to other heterogeneous reactions, significantly advancing UV–vis spectroscopic techniques toward practical integration into automated experimental platforms for probing aqueous chemical processes and beyond.
Integrated Solution for As(III) Contamination in Water Based on Crystalline Porous Organic Salts
Authors: Yang Xiaoxia , Guo Qi , Liu Xingman , Ma Jing‐xin 
Published: June 2024

AbstractA stable crystalline organic porous salt (CPOSs‐NXU‐1) with 1D apertures has been assembled by the solvothermal method, which shows high‐sensitivity “turn‐on” fluorescence detection and large‐capacity adsorption of As(III) ions in water. The detection limits, saturated adsorption capacity, and removal rate of CPOSs‐NXU‐1 for As(III) ions in an aqueous solution can reach 74.34 nm (5.57 ppb), 451.01 mg g−1, and 99.6%, respectively, at pH = 7 and room temperature. With the aid of XPS, IR, Raman, and DFT theoretical calculations, it is determined that CPOSs‐NXU‐1 adsorbed As(III) ions in the form of H2AsO3− and H3AsO3 through hydrogen bonding between the host and guest. The mechanism for fluorescence sensitization of As(III) ions to CPOSs‐NXU‐1 is mainly to increase the energy level difference between the ground state and excited state investigated by UV–vis absorption spectra, UV–vis diffuse reflectance spectra, and theoretical calculations. By constructing fluorescent CPOSs, an integrated solution has been achieved to treating As(III) contamination in the water that is equipped with detection and removal. These results blaze a promising path for addressing trivalent arsenic contamination in water efficiently, rapidly, and economically.
Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology
Authors: Pramotton Francesca Michela , Spitz Sarah , Kamm Roger D. 
Published: June 2024

AbstractNeurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing a significant global health challenge as well as a high socioeconomic burden. With aging constituting one of the main risk factors for some NDDs such as Alzheimer's disease (AD) and Parkinson's disease (PD), this societal toll is expected to rise considering the predicted increase in the aging population as well as the limited progress in the development of effective therapeutics. To address the high failure rates in clinical trials, legislative changes permitting the use of alternatives to traditional pre‐clinical in vivo models are implemented. In this regard, microphysiological systems (MPS) such as organ‐on‐a‐chip (OoC) platforms constitute a promising tool, due to their ability to mimic complex and human‐specific tissue niches in vitro. This review summarizes the current progress in modeling NDDs using OoC technology and discusses five critical aspects still insufficiently addressed in OoC models to date. Taking these aspects into consideration in the future MPS will advance the modeling of NDDs in vitro and increase their translational value in the clinical setting.
Easy‐to‐Lay Poly‐N Heterocyclic Additives Enable Long‐Term Stabilization of Zinc‐Ion Capacitor Anodes under Deep Plating/Stripping
Authors: Bu Yongfeng , Kang Qin , Zhu Zhaomin , Zhang Hongyu , Li Yuman , Wang Shihao , Tang Shengda , Pan Li , Yang Lijun , Liang Hongyu 
Published: June 2024

AbstractAddition of organic compounds containing O/N heteroatoms to aqueous electrolytes such as ZnSO4 (ZS) solutions is one of the effective strategies to inhibit Zn anode dendrites and side reactions. However, addressing the stability of Zn plating/stripping at high current densities and areal capacities by this method is still a challenge, especially in capacitors known for high power and long life. Herein, an organic heterocyclic compound of 1, 4, 7, 10‐tetraazacyclododecane (TC) containing four symmetrically distributed N atoms is employed as ZS additive, expanding the life of Zn anodes from ≈ 30 h to 1000 and 240 h at deep plating/stripping conditions of 10 and 20 mA cm−2/mAh cm−2, respectively; the cumulative capacity is as high as 5.0 Ah cm−2 with 99% Coulombic efficiency, far exceeding reported additives. TC with higher binding energies than H2O for Zn species tends to adsorb to Zn (002) in a lying manner and participate in the solvation shell of Zn2+, thus avoiding Zn dendrites and side‐reaction damage, especially at high current densities. The TC‐endowed Zn anode's stability under such extreme conditions is verified in Zn‐ion capacitors (i.e., > 94.6% capacity retention after 28 000 cycles), providing new insights into the development of high‐power Zn‐based energy storage devices.
Manipulating the Crosstalk between Cancer and Immunosuppressive Cells with Phototherapeutic Gold‐Nanohut for Reprogramming Tumor Microenvironment
Authors: Cheng Hung‐Wei , Lee Wei , Hsu Fei‐Ting , Lai Yen‐Ho , Huang Shu‐Rou , Lim Chris Seh Hong , Lin Zhen‐Kai , Hsu Shih‐Chao , Chiang Chih‐Sheng , Jeng Long‐Bin , Shyu Woei‐Cherng , Chen San‐Yuan 
Published: June 2024

AbstractPhotoimmunotherapy faces challenges due to insufficient intratumoral accumulation of photothermal agents and the reversion of the cancer‐immunity cycle during treatment. In this study, an anti‐PD‐L1‐immobilized magnetic gold nanohut, AuNH‐2‐Ab, with photoresponsive, thermosensitive, and immunomodulatory properties to effectively suppress the growth of primary tumors, elevate immunogenic cell death (ICD) levels, reverse the tumor immune microenvironment (TIME), and consequently inhibit metastases are developed. AuNH‐2‐Ab achieves high tumor accumulation (9.54% injected dose) following systemic administration, allowing the modulation of hyperthermia dose of over 50 °C in the tumor. By optimizing the hyperthermia dose, AuNH‐2‐Ab simultaneously target and eliminate cancer cells and tumor‐associated macrophages, thereby activating potent antitumor immunity without being compromised by immunosuppressive elements. Hyperthermia/pH induced morphological transformation of AuNH‐2‐Ab involving the detachment of the surface antibody for in situ PD‐L1 inhibition, and exposure of the inner fucoidan layer for natural killer (NK) cell activation. This precision photoimmunotherapy approach reprograms the TIME, significantly prolongs survival in a murine hepatocellular carcinoma model (Hep55.1c), and harnesses the synergistic effects of ICD production and checkpoint inhibitors by utilizing a single nanoplatform.
Female social dynamics as viewed from grooming networks in the Central Himalayan Langur (Semnopithecus schistaceus)
Authors: Nautiyal Himani , Romano Valéria , Tanaka Hiroyuki , Huffman Michael A. 
Published: June 2024

AbstractEnhanced survival and reproduction are associated with an individual's direct and indirect social connections with members of a group. Yet, the role of these connections is little known in a vast range of primate species. We studied female Central Himalayan Langur (CHL) to investigate the link between four specific attributes (dominance rank, age, genetic relatedness, and the presence of females carrying infants) and a female's direct and indirect social relationships. By analyzing grooming networks, we revealed different behavioral strategies: high‐ranking females form relationships with many females (high degree), whereas females with dependent infants have strong relationships (high strength and eigenvector). Subadult females are important individuals that hold the social network together (high betweenness), while an immigrant female strategy is to integrate herself into the group by forming strong bonds with females who themselves have strong bonds (high eigenvector). Our study sheds light on how behavioral strategies shape female CHL grooming networks, which may help them to secure fitness and survival advantages.
Shaft structure of the first metatarsal contains a strong phylogenetic signal in apes and humans
Authors: Tomizawa Yuma , Nakatsukasa Masato , Ponce de León Marcia S. , Zollikofer Christoph P. E. , Morimoto Naoki 
Published: June 2024

AbstractObjectivesMetatarsal bones constitute a key functional unit of the foot in primates. While the form‐function relationships of metatarsals have been extensively studied, particularly in relation to the loss of the grasping ability of the foot in humans in contrast to apes, the effect of phyletic history on the metatarsal morphology and its variability remains largely unknown.Materials and MethodsHere, we evaluate how the strength of the phylogenetic signal varies from the first to the fifth metatarsal in humans, chimpanzees, gorillas, orangutans, gibbons, and Japanese macaques. We use computed tomography imaging and morphometric mapping to quantify the second moment of area around and along the metatarsal shaft and evaluate the strength of the phylogenetic signal with multivariate K‐statistics.ResultsThe shaft structure of the first metatarsal, but not the others, correlates well with the phylogeny of apes and humans.DiscussionGiven the importance of the first metatarsal for grasping and bipedal/quadrupedal locomotion, the strong phylogenetic but weak functional signal in its structure is unexpected. These findings suggest that the evolutionary diversification of hominoid locomotor behaviors, including human bipedality, is only partly reflected in form‐function relationships of key skeletal elements, and that phylogenetic history acted as a major evolutionary constraint.
Assessing the existence of the male–female health‐survival paradox in the past: Dental caries in medieval London
Authors: DeWitte Sharon N. 
Published: June 2024

AbstractObjectivesThis study seeks to identify signals of the male–female health‐survival paradox in medieval London.Materials and MethodsThis study uses skeletal data on age, sex, dental caries (n = 592) and antemortem tooth loss (n = 819) from adult individuals from medieval London cemeteries (c. 1200–1540 CE). The association between age and dental caries was assessed using binary logistic regression. The associations among age, time period (pre‐ vs. post‐Black Death), oral biomarker (dental caries or antemortem tooth loss), and sex were tested using hierarchical log‐linear analysis.ResultsThe analyses reveal significantly higher odds of dental caries with increasing adult ages, more older adults after the Black Death, different age distributions of dental caries between the sexes, and a greater decrease in the prevalence of dental caries for females after the Black Death. These results appear not to be an artifact of trends in AMTL. However, this study does not yield evidence suggesting that females experienced both a survival advantage and a decline in oral health at late adult ages after the Black Death relative to males.ConclusionsThese results do not provide evidence of the existence of a male–female health‐survival paradox, but they do corroborate existing evidence of improvements in health in general in the aftermath of the Black Death. The decreased prevalence of dental caries after the Black Death may reflect dietary improvements or the effects of selective mortality during the epidemic.
Improving comprehensive performance of norbornene‐furan functionalized benzoxazine resins by regulating the bridge length
Authors: Yang Yi , Lu Yin , Zhang Kan 
Published: June 2024

AbstractIn this study, we designed and synthesized a series of norbornene‐furan functionalized benzoxazine monomers (HPAP‐fa, HPAMP‐fa, and HPTM‐fa) by regulating the bridge length in benzoxazine structure in order to improve the comprehensive performance of norbornene‐furan functionalized benzoxazine system. This research systematically examined the impact of flexible segments on the structural information, polymerization behaviors, thermal stability, and flame retardancy of resulting polybenzoxazines. Initially, the structural characteristics of benzoxazine were confirmed through nuclear magnetic resonance, Fourier‐transform infrared (FT‐IR), and HR‐MS. Subsequently, the polymerization mechanisms of each benzoxazine monomer were investigated utilizing differential scanning calorimeter and in situ FT‐IR analyses. Finally, the thermal stability and flame‐retardant properties were investigated by TGA and micro‐combustion calorimetry measurements. Consequently, HPAP‐fa exhibited the lowest polymerization temperature and the corresponding poly(HPAP‐fa) showed very high thermal stability (Td5 of 392°C and Td10 of 437°C) as well as excellent flame retardancy (HRC of 83.7 J g−1 K−1), which shows a significant improvement compared to poly(HPTM‐fa). As a result, the modulation of bridge segments within the monomer represents a viable approach towards enhancing the holistic efficacy of norbornene‐furan functionalized benzoxazine systems.
Predicting seagrass ecosystem resilience to marine heatwave events of variable duration, frequency and re‐occurrence patterns with gaps
Authors: Hatum Paula Sobenko , McMahon Kathryn , Mengersen Kerrie , Kilminster Kieryn , Wu Paul Pao‐Yen 
Published: June 2024

AbstractBackgroundSeagrass, a vital primary producer habitat, is crucial for maintaining high biodiversity and offers numerous ecosystem services globally. The increasing severity and frequency of marine heatwaves, exacerbated by climate change, pose significant risks to seagrass meadows.AimsThis study acknowledges the uncertainty and variability of marine heatwave scenarios and aims to aid managers and policymakers in understanding simulated responses of seagrass to different durations, frequencies and recurrence gaps of marine heatwaves.Materials and MethodsUsing expert knowledge and observed data, we refined a global Dynamic Bayesian Network (DBN) model for a specific case study on Halophila ovalis in Leschenault Estuary, Australia. The model evaluates the potential impact of marine heatwaves on seagrass resilience, examining stress resistance, recovery and extinction risk.ResultsSimulations of different marine heatwave scenarios reveal significant impacts on seagrass ecosystems. Scenarios ranged from 30‐ to 90‐day heatwaves, with longer durations causing more significant biomass decline, reduced resistance, higher extinction risk and prolonged recovery. For instance, recovery time may increase from 18 to 26 months with four 60‐day and from 24 to 47 months with four 90‐day marine heatwave events. Increasing the frequency of marine heatwaves from one to four annual events, with no gaps between occurrences, could raise extinction risk from 11% to 55% for 60‐day events and from 17% to 83% for 90‐day events. However, introducing gaps between heatwaves enhanced resilience, with spaced events showing lower extinction risks and quicker recovery than consecutive yearly events.DiscussionThe study demonstrates the DBN model's utility in simulating the impact of marine heatwaves on seagrass, providing tools for risk‐informed assessment of management and restoration efforts. While these simulations align with existing research on temperature impacts on seagrass, they are not empirical.ConclusionFurther research is necessary to expand our understanding of climate change effects on seagrass ecosystems, guide policy and develop strategies to strengthen marine ecosystem resilience.
Assessment of drug–drug interaction of dapagliflozin with LCZ696 based on an LC–MS/MS method
Authors: Wang Lingmei , Liang Bohan , Teng Yunhua , Zhang Chenchen , Zhang Yufeng , Zhang Zhidan , Zhang Aijie , Dong Shiqi , Fan Huirong 
Published: June 2024

AbstractThe co‐administration of dapagliflozin (DPF) and sacubitril/valsartan (LCZ696) has emerged as a promising therapeutic approach for managing heart failure. Given that DPF and LCZ696 are substrates for P‐glycoprotein, there is a plausible potential for drug–drug interactions when administered concomitantly. To investigate the pharmacokinetic changes when these drugs are co‐administered, we have established and validated a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method capable of simultaneously detecting DPF, LBQ657 (the active metabolite of sacubitril) and valsartan in rat plasma. This method has demonstrated selectivity, sensitivity, and accuracy. Drug–drug interactions were examined by the LC–MS/MS method. The mechanisms were investigated using everted intestinal sac models and Caco‐2 cells. The results showed that DPF significantly increased the area under the curve (AUC(0–t)) (3,563.3 ± 651.7 vs. 7,146.5 ± 1,714.9 h μg/L) of LBQ657 (the active metabolite of sacubitril) and the AUC(0–t) (24,022.4 ± 6,774.3 vs. 55,728.3 ± 32,446.3 h μg/L) of valsartan after oral co‐administration. Dapagliflozin significantly increased the amount of LBQ657 and valsartan in intestinal sacs by 1‐ and 1.25‐fold at 2.25 h. Caco‐2 cell uptake studies confirmed that P‐glycoprotein is the transporter involved in this interaction. This finding enhances the understanding of drug–drug interactions in the treatment of heart failure and provides a guidence for clinical therapy.
Sustainability meets metaverse: A conceptual framework of sustainable dimensions of the metaverse
Authors: Rajguru Kunjan , Brüggemann Philipp 
Published: June 2024

AbstractThe rise of the metaverse brings about a host of changes for consumers, impacting various aspects of their online experiences, personal and professional relationships, and overall welfare. Consumers are increasingly mindful of sustainability in their online and offline activities. Thus, users will become aware of sustainable solutions for their virtual engagement. Additionally, there is growing pressure on consumers, corporations, and governments to adopt sustainable practices due to mounting concerns about climate change. The United Nations has responded to these concerns by setting Sustainable Development Goals. In this context, our research combines these goals with the dimensions of the metaverse, leading to the identification of the Sustainable Dimensions of the Metaverse. In the context of research and practice implications, we illustrate how the proposed framework can be harnessed to promote a more sustainable future for society. Ultimately, we urge all stakeholders involved in the metaverse to integrate sustainability considerations from the outset of its development. Addressing sustainability concerns retroactively may present challenges and prove to be substantially more complex and resource‐intensive.
Controlled mitral valvuloplasty using steerable catheter‐ waist‐ formed balloon system: A clinical case series
Authors: Nobile Edoardo , Piscione Mariagrazia , Cammalleri Valeria , Gaudio Dario , Antonelli Giorgio , De Luca Valeria Maria , Coletti Federica , Carpenito Myriam , Cocco Nino , Nusca Annunziata , Ussia Gian Paolo 
Published: June 2024

AbstractAs the general population ages, the incidence of degenerative mitral stenosis (MS) among patients has increased. Percutaneous mitral valvuloplasty (PMV) has emerged as a well‐established option for mitral rheumatic stenosis with specific characteristics. However, a blank therapeutic space must be filled with the treatment options for degenerative or rheumatic mitral stenosis in patients with many comorbidities and contraindication for valvuloplasty. We here present a comprehensive overview of the current possibilities, despite their scarce success. That is the reason why we propose a case series to facilitate a better understanding of our innovative technique in this challenging clinical context.