bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysen an alten Kris-Dolchen sowie Nachschmiedung eines Dolchs
Authors: Scheiblechner Wolfgang , Strobl Susanne , Haubner Roland 
Published: July 2024

ZusammenfassungIndonesische Krisdolche wurden mittels eines tragbaren RFA-Geräts untersucht. Zwei von vier Krisen enthielten Ni, was auf die Verwendung von Meteoriteneisen hindeutet. Bei einem weiteren Kris aus Privatbesitz wurden Ni Konzentrationen im Prozentbereich gemessen, was eher auf die Verwendung eines Ni-reichen Stahls hindeutet. Es wurde auch ein gewellter Kris nachgeschmiedet und das Gefüge sowie die Qualität der Feuerverschweißungen metallographisch überprüft.
Health Literacy und Empowerment für Menschen mit schweren psychischen Erkrankungen
Authors: Mües Hanna M. , Grabovac Igor , Löffler-Stastka Henriette 
Published: July 2024

ZusammenfassungPsychische Störungen gehen mit einer erhöhten Krankheitslast einher. Des Weiteren stellen somatische Erkrankungen, u. a. aufgrund erhöhter Risikofaktoren sowie des „diagnostic overshadowing“, eine zusätzliche potenzielle Problematik bei Menschen mit psychischen Erkrankungen dar. Dennoch suchen Menschen mit psychischen Störungen erst spät oder gar keine professionelle Unterstützung. Eine Förderung der Health Literacy und des Empowerments stellen wichtige Ansatzpunkte für die Gesundheitsförderung und die Verringerung von Ungleichheiten in der Gesundheitsversorgung von Menschen mit psychischen Erkrankungen dar. In diesem Beitrag werden die Konzepte Health Literacy und Empowerment näher erläutert, Möglichkeiten zur Förderung in der Praxis präsentiert und ein Fallbeispiel vorgestellt. Das Gesundheitspersonal spielt für den Ausbau von Health Literacy und Empowerment eine entscheidende Rolle.
The water weakening effect on the progressive slope failure under excavation and rainfall conditions
Authors: Yu Xiang , Zhao Tao , Gong Bin , Tang Chun’an 
Published: July 2024

AbstractThe water weakening effect refers to the gradual deterioration of soil mechanical properties under long-term saturation. This paper analyzed the impact of water weakening on slope stability under alternating excavation and rainfall. The field investigation speculated shale hydration as the cause of overall slope instability. The mechanical parameters of hydrated shale were determined by the parameter inversion and empirical estimation methods. The simulations were used to restore the process of parameter weakening and slope failure, and confirmed the fact that hydration causes landslide. Furthermore, the failure mechanism of slope and support structure under hydration were investigated. The results show that the mechanical parameters of the slope decreased linearly, whereas the plastic strain–time and total displacement-maximum shear stress curves of the hydrated shale exhibited three stages: slow initial growth, rapid growth in the middle term, and rapid increase in the later period; the rate of slope deformation and the factor of safety reduction also gradually increase over time; under middle stage of hydration, the middle to rear of shale were extruded, while the front first underwent tensile shear deformation, forming a plastic zone of at rear and front excavated slope; In the late stage, hydrated shale quickly reaches its yield limit (maximum shear stress of 270 kPa), the middle and rear shale is damaged and compresses the front, causing it to transform from tensile shear to compressive shear failure. The plastic zone in the rear extends forward and connects with the front ones, forming an overall landslide. Besides, preventing deep landslides caused by hydration through waterproofing, drainage, protection, and support for excavated slopes has proven difficult. Therefore, it is necessary to redesign treatment schemes based on the characteristics of stress, strain, and seepage.
Assessing the readability and quality of online patient information for laser tattoo removal
Authors: Jean-Pierre Philippe , Scheinkman Ryan , Nouri Keyvan 
Published: July 2024

Abstract
Just as tattoos continue to increase in popularity, many people with tattoos also seek removal, often due to career concerns. Prospective clients interested in laser tattoo removal may do research about the procedure online, as the internet increasingly becomes a resource to get preliminary health information. However, it is important that the online health information on the topic be of high quality and be accessible to all patients. We analyzed 77 websites from a Google search query using the terms “Laser tattoo removal patient Information” and “Laser tattoo removal patient Instructions” to assess this. The websites were evaluated for their readability using multiple validated indices and comprehensiveness. We found that websites had a broad readability range, from elementary to college, though most were above the recommended eighth-grade reading level. Less than half of the websites adequately discussed the increased risk of pigmentary complications in the skin of color clients or emphasized the importance of consulting with a board-certified dermatologist/plastic surgeon before the procedure. Over 90% of the websites noted that multiple laser treatments are likely needed for complete clearance of tattoos. The findings from our study underscore a significant gap in the accessibility and quality of online information for patients considering laser tattoo removal, particularly in addressing specific risks for patients with darker skin tones and emphasizing the need for consulting a board-certified physician before undergoing the procedure. It is important that online resources for laser tattoo removal be appropriately written to allow better decision-making, expectations, and future satisfaction for potential clients interested in the procedure.
GPC2 promotes prostate cancer progression via MDK-mediated activation of PI3K/AKT signaling pathway
Authors: Chen Sijin , Liao Jiaxing , Li Juhua , Wang Saihui 
Published: July 2024

AbstractProstate cancer is a major medical problem for men worldwide. Advanced prostate cancer is currently incurable. Recently, much attention was paid to the role of GPC2 in the field of oncology. Nevertheless, there have been no investigations of GPC2 and its regulatory mechanism in prostate cancer. Here, we revealed a novel action of GPC2 and a tumor promoting mechanism in prostate cancer. GPC2 was upregulated in prostate cancer tissues and cell lines. Higher expression of GPC2 was correlated with higher Gleason score, lymphatic metastasis, and worse overall survival in prostate cancer patients. Decreased expression of GPC2 inhibited cell proliferation, migration, and invasion in prostate cancer, whereas GPC2 overexpression promoted these properties. Mechanistically, GPC2 promoted the activation of PI3K/AKT signaling pathway through MDK. The rescue assay results in prostate cancer cells demonstrated that overexpression of MDK could attenuate GPC2 knockdown induced inactivation of PI3K/AKT signaling and partly reverse GPC2 knockdown induced inhibition of cell proliferation, migration, and invasion. In all, our study identified GPC2 as an oncogene in prostate cancer. GPC2 promoted prostate cancer cell proliferation, migration, and invasion via MDK-mediated activation of PI3K/AKT signaling pathway. GPC2 might be a promising prognosis predictor and potential therapeutic target in prostate cancer.
Phase 3 THOR Japanese subgroup analysis: erdafitinib in advanced or metastatic urothelial cancer and fibroblast growth factor receptor alterations
Authors: Matsubara Nobuaki , Miura Yuji , Nishiyama Hiroyuki , Taoka Rikiya , Kojima Takahiro , Shimizu Nobuaki , Hwang Jason , Ote Tatsuya , Oyama Ryo , Toyoizumi Kiichiro , Mukhopadhyay Sutapa , Triantos Spyros , Deprince Kris , Loriot Yohann 
Published: July 2024

Abstract
Background
In the THOR trial (NCT03390504) Cohort 1, erdafitinib demonstrated significantly prolonged overall survival (OS) (median 12.1 versus 7.8 months) and reduced risk of death by 36% (hazard ratio 0.64, P = 0.005) compared with chemotherapy in metastatic urothelial carcinoma (mUC) patients with FGFR alterations who progressed after ≥ 1 prior treatments, including anti-PD-(L)1. There have been no reports of the Japanese subgroup results yet.

Methods
THOR Cohort 1 randomized patients to erdafitinib once daily or docetaxel/vinflunine once every 3 weeks. Primary endpoint was OS. Secondary endpoints included progression-free survival (PFS) and objective response rate (ORR). No specific statistical power was set for this Japanese subgroup analysis.

Results
Of 266 patients randomized, 27 (14 erdafitinib; 13 chemotherapy) were Japanese. Baseline characteristics were generally similar between treatments and to the overall population, except for more males, lower body weight, and more upper tract primary tumors among Japanese patients. Compared with chemotherapy, erdafitinib showed improved OS (median 25.4 versus 12.4 months), PFS (median 8.4 versus 2.9 months) and ORR (57.1% versus 15.4%). Any grade treatment-related adverse events (AEs) occurred in all patients from both arms but Grade 3/4 AEs and AEs leading to discontinuation were lower in the erdafitinib arm. No new safety signals were observed in the Japanese subgroup.

Conclusion
In the Japanese subgroup, erdafitinib showed improved survival and response compared to chemotherapy, with no new safety concerns. These results support erdafitinib as a treatment option for Japanese mUC patients with FGFR alterations, and early FGFR testing after diagnosis of mUC should be considered.
The influence of conservation policies and legislations on communities in Tanzania
Authors: Kegamba Juma J. , Sangha Kamaljit K. , Wurm Penelope A.S. , Kideghesho Jafari R. , Garnett Stephen T. 
Published: July 2024

AbstractBenefit-sharing mechanisms have been instrumental in securing the support of local communities living on the edge of protected areas, and in resolving human-wildlife conflicts. Understanding how current conservation policies influence benefit-sharing and the management of human-wildlife conflicts is vital for designing strong mechanisms to achieve both conservation and ethical community outcomes. Here we examined how benefit-sharing and human-wildlife conflicts are acknowledged and addressed within the current conservation policies (wildlife policies, legislations, regulations and strategic plans) using the Greater Serengeti Ecosystem (GSE) as a case study. The fourteen policies focusing primarily on wildlife conservation in Tanzania are analysed. We also drew on the findings of three studies conducted during 2021 and 2022 documenting community interactions with wildlife and adjacent protected areas. These studies covered the types of benefit provided by various conservation institutions to local communities, the effectiveness of benefit-sharing mechanisms, and the conservation-related losses incurred by communities. The study uncovered a wide range of benefits provided to local communities in the form of social amenities, livelihood support and employment. However, the losses and costs experienced are far greater than these benefits. Integrating these findings with policy analysis, we identified that the main limitations reducing the impacts of benefits in motivating positive conservation behaviours to be: losses of livestock and crops were more than four times the value of benefits/compensation offered to communities; a lack of details and clarity of benefit-sharing mechanisms; benefit/conservation rates that have not been indexed against inflation and; shortcomings in implementation. To achieve conservation outcomes, we recommend revising the conservation policies and legislation across the country in collaboration with local communities who experience the impacts of conservation in their day-to-day life. We also propose a coordinated approach for all conservation institutions managing wildlife to address widespread human-wildlife conflicts across the country effectively and to achieve better conservation outcomes rather than leaving that task to a single organization (i.e. Tanzania Wildlife Management Authority).
Curve-lifted codes for local recovery using lines
Authors: Matthews Gretchen L. , Morrison Travis , Murphy Aidan W. 
Published: July 2024

AbstractIn this paper, we introduce curve-lifted codes over fields of arbitrary characteristic, inspired by Hermitian-lifted codes over $$\mathbb {F}_{2^r}$$

F

2
r

. These codes are designed for locality and availability, and their particular parameters depend on the choice of curve and its properties. Due to the construction, the numbers of rational points of intersection between curves and lines play a key role. To demonstrate that and generate new families of locally recoverable codes (LRCs) with high availabilty, we focus on norm-trace-lifted codes.
Soil carbon storage under different types of arid land use in Algeria
Authors: Benslama Abderraouf , Benbrahim Fouzi , Rym-Gadoum Lydia , Gómez-Lucas Ignacio , Mordan-Vidal Manuel Miguel , Navarro-Pedreño Jose , Bech-Borrás Jaume 
Published: July 2024

AbstractThis study aims to assess the amount of organic carbon stored in soils, as it is an intention of knowing the sustainable soil management, by using two common methods for determining soil organic matter (SOM), namely oxidation with acidified wet dichromate (Walkley–Black method-WB) and loss on ignition (LOI). The study was carried with soil samples collected from a depth of 0 to 30 cm in the Saharan arid region of Ghardaïa (Algeria), with different land uses: agricultural, forest and pastoral. The results obtained from the LOI and WB methods were subjected to statistical analysis, and the relations between both methods were tested to investigate their relationship. The mean percentage of SOM values were 1.86, 2.42, 1.54 by using LOI, but, lower values of 0.34, 0.33, 0.36 were determined by using WB method, for agricultural, forest and pastoral soils respectively. A weak linear relationship between the two analytical procedures was obtained (R2 of 0.19 and 0.13 for agricultural and forest soils), while a medium relationship (R2 = 0.65) was found for pastoral soils when using linear adjustment. However, the opposite behaviour was found when we use the logarithmic adjustment. The study outcomes indicated discrepancies in the measurements of SOM values between the two methods, been higher those estimated with LOI. Finally, in order to identify the best methodology to measure soil organic matter in arid soils, more research is required in these extreme arid regions as they are a gap in world soil organic matter maps.
Neuroprotective efficiency of celecoxib vesicular bilosomes for the management of lipopolysaccharide-induced Alzheimer in mice employing 23 full factorial design
Authors: Darwish Asmaa Badawy , Salama Abeer , Younis Mostafa Mohammed 
Published: July 2024

AbstractThe aim of this study was to develop and evaluate bilosomes loaded with Celecoxib (CXB) for the efficient treatment of Alzheimer. The thin-film hydration approach was utilized in the formulation of CXB bilosomes (CXB-BLs). The study used a 23-factorial design to investigate the impact of several formulation variables. Three separate parameters were investigated: bile salt type (X1), medication amount (X2), and lipid–bile salt ratio (X3). The dependent responses included entrapment efficiency (Y1: EE %), particle size (Y2: PS), and zeta potential (Y3: ZP). The formulation factors were statistically optimized using the Design-Expert® program. The vesicles demonstrated remarkable CXB encapsulation efficiency, ranging from 94.16 ± 1.91 to 98.38 ± 0.85%. The vesicle sizes ranged from 241.8 ± 6.74 to 352 ± 2.34 nm. The produced formulations have high negative zeta potential values, indicating strong stability. Transmission electron microscopy (TEM) revealed that the optimized vesicles had a spherical form. CXB release from BLs was biphasic, with the release pattern following Higuchi's model. In vivo studies confirmed the efficiency of CXB-BLs in management of lipopolysaccharide-induced Alzheimer as CXB-BLs ameliorated cognitive dysfunction, decreased acetylcholinesterase (AChE), and inhibited neuro-inflammation and neuro-degeneration through reducing Toll-like receptor (TLR4), and Interleukin-1β (IL-1β) levels. The findings suggested that the created CXB-BLs could be a potential drug delivery strategy for Alzheimer's treatment.
Completion of Upper Secondary Mainstream School in Autistic Students in Sweden
Authors: Stark Isidora , Rast Jessica E. , Lundberg Michael , Döring Nora , Ohlis Anna , Idring Nordström Selma , Rai Dheeraj , Magnusson Cecilia 
Published: July 2024

AbstractHigher education is an increasingly necessary achievement to attain employment. However, even in cases where a student has the academic skills to succeed, educational environments may not support students across all other domains necessary for education success, including social and communication needs. This is especially true for students with disabilities and autistic students, where the rate of completion of non-compulsory education is unknown. We used the Stockholm Youth Cohort (children aged 0–17 years from 2001 to 2011), a total population cohort (N = 736,180) including 3,918 autistic individuals, to investigate the association between autism without intellectual disability and completion of upper secondary education. We assessed the impact of sex and co-occurring Attention-Deficit/Hyperactivity Disorder (ADHD) on this association. By age 20 years (the expected age of completion), 68% of autistic students and 91% of non-autistic students admitted to upper secondary education had completed. In logistic regression models adjusted for student demographics, autistic students had almost five-fold higher odds of not completing secondary school (OR 4.90, 95% CI 4.56 5.26) compared to their non-autistic peers. Autistic students with ADHD had particularly high odds of non-completion of upper secondary school. Autistic students without intellectual disability attending mainstream education are substantially less likely to complete upper secondary education as compared to their peers. These findings have implications for the appraisal of how inclusive school policies serve autistic students’ academic and social needs, ultimately addressing population health and independent living.
A simple method for repeated in vivo sperm collection from laboratory mice
Authors: Burgstaller Sophie M. , Auer Kerstin E. , Rülicke Thomas 
Published: July 2024

Abstract
Purpose
Mouse spermatozoa for archiving laboratory mice or for in vitro fertilization (IVF) are routinely obtained from the cauda epididymis of adult males sacrificed for this purpose. To avoid the death of the donor, we tested whether a precisely timed interruption of the mating act could be used for repeated sperm collection from laboratory mice.

Methods
Sperm donors (B6D2F1) were mated with a receptive female, and mating behavior was observed. The stud was separated from the female 1–2 s after the onset of the ejaculatory shudder. The ejected copulatory plug with the yellowish viscous ejaculate was carefully removed from the penile cup.

Results
A total of 80 ejaculates were successfully obtained from 100 ejaculations. The latency to first mount was 1.1 ± 1.1 min (mean ± SD) and to ejaculation 8.1 ± 4.7 min. The average number of mounts to ejaculation was 10.5 ± 5.8, and the mean number of spermatozoa per collected ejaculate was 1.86 ± 1.05 × 106. An average fertilization rate of 76% was observed after IVF.

Conclusions
Separating the stud from the female just before ejaculation is feasible, easy to learn, and requires no special equipment. The sperm count of collected ejaculates is lower than natural ejaculations, but higher than previous in vivo sperm collection methods achieved. We recommend this simple sperm collection method in mice, especially when the donor cannot be sacrificed and/or repeated sperm collection from the same animal is required for experimental purposes.
Towards the Development of an In-Process Quality Monitoring System for Polyethylene Recyclates by Pyrolysis Gas Chromatography Ion Mobility Spectrometry
Authors: Ahrens André , Shamsuyeva Madina , Endres Hans-Josef , Zimmermann Stefan 
Published: July 2024

AbstractOver the past few decades, the topic of recycling has become increasingly prominent in the field of sustainable materials and circular economy. One significant challenge is the physical separation of different types of plastics to obtain recyclates of one plastic type as pure as possible with comparable quality and properties to those of virgin material. Given the substantial effort involved in such separation, small amounts of contamination from other plastics may be tolerated. However, these contaminations must be monitored to ensure high-level recyclate quality. In recent years, compact, low-cost ion mobility spectrometers (IMS) with high analytical performance have been developed, and have thus become widely used in a variety of sensing applications. Due to their high sensitivity, IMS are particularly suited for detecting lowest concentration levels of various compounds, as required for the detection of impurities in recyclate quality monitoring. When coupled to a miniature gas chromatograph (GC), GC-IMS reach even higher separation power while being still compact. To bring recyclate samples to the gas phase, pyrolysis (Py) is used in this work. A first feasibility study was conducted to assess the potential of such a pyrolysis–gas chromatography-ion mobility spectrometer (Py-GC-IMS) with the objective of detecting contaminations of polyethylene terephthalate (PET) in polyethylene (PE) recyclates. The study clearly demonstrates the ability to identify PET-related fingerprints while suppressing the PE background matrix by design so that Py-GC-IMS seems a promising approach for in-process monitoring PET contaminations in PE recyclates.
The effect of landscape composition, complexity, and heterogeneity on bird richness: a systematic review and meta-analysis on a global scale
Authors: Lu Xinghao , Jia Yifei , Wang Yuncai 
Published: July 2024

Abstract
Context
Birds, as indicators of biodiversity, are experiencing habitat reduction and loss due to landscape changes. Evidence is mounting that the response of bird richness to landscape patterns remains controversial on a global scale. In this study, we conducted a quantitative global synthesis to gain a comprehensive understanding of this relationship. Our findings contribute to the development of bird conservation strategies that align with the objectives of SDG15.

Objective
Through a quantitative review, this study investigated the effects of landscape patterns on bird richness and analyzed the sources of heterogeneity in the results.

Methods
A random-effects model was utilized to merge the impacts of landscape metrics on bird richness, and a meta-regression analysis was performed to investigate the origins of heterogeneity.

Results
The review encompassed 101 articles from 51 countries worldwide. Field sampling emerged as the primary method for acquiring bird data, with multiple linear regression and generalized linear models as the main analytical approaches. The meta-analysis results highlighted landscape area as a crucial factor influencing bird richness. Regarding landscape composition, the proportions of forests, shrublands, and water bodies positively impacted bird richness, while agricultural land and urban land had negative effects. The relationship between landscape complexity and bird richness is influenced by factors, including net primary productivity (NPP) and precipitation. Landscape heterogeneity was identified as a contributing factor to increased species richness.

Conclusion
Compared to landscape complexity, indicators of landscape composition and heterogeneity are more suitable as reference tools for bird conservation. The results of landscape complexity exhibit variation. Moreover, our findings underscore the crucial role of preserving forested areas in supporting bird diversity, emphasizing the necessity to account for regional variations when establishing forest cover thresholds.