bluuebunny/crossref_metadata_2025_split huggingface dataset:
The 1‐year decline in estimated glomerular filtration rate (eGFR) after radical nephrectomy in patients with renal masses and matched living kidney donors is the same
Authors: Hew Miki N. , Opondo Dedan , Cordeiro Ernesto R. , van Donselaar‐van der Pant Karlijn A.M.I. , Bemelman Frederike J. , Idu Mirza M. , de la Rosette Jean J.M.C.H. , Laguna M. Pilar 
Published: July 2013

Objectives
To determine short‐term differences in renal function evolution between patients with renal cell carcinoma (RCC) submitted to radical nephrectomy (RN) and living kidney donors matched for age and gender.
To assess the role of co‐morbidity as a risk factor for developing an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2.
Patients and Methods
In this retrospective study patients undergoing Radical Nefrectomy (RN) between January 2000 and February 2011 for suspicion of localised RCC were matched by age and gender to living kidney donors.
Renal function was compared between the groups using the Modification in Diet and Renal Disease (MDRD) equation at 1 year after RN.
Charlson co‐morbidity score, incidence of hypertension, diabetes and cardiovascular disease were compared and assessed as predictors for developing an eGFR of <60 mL/min/1.73 m2.
Results
In all, 196 patients were included, 98 in each group.
The mean age was respectively 60.6 (RCC group) and 59.1 years (donors). The 1‐year postoperative mean eGFR (available in 89 patients with RCC and 87 donors) was similar, at a mean (sd) of 56.7 (16.4) mL/min/1.73 m2 in patients with RCC and 56.2 (9.8) mL/min/1.73 m2 in donors (P = 0.83).
In patients with RCC the incidence and severity of co‐morbidities was significantly higher.
A preoperative eGFR of 60–89 mL/min/1.73 m2 was the only independent risk factor for developing a postoperative eGFR of <60 mL/min/1.73 m2 (odds ratio 4.4, confidence interval 2.1–9.5, P < 0.001, 95% confidence interval).
Conclusions
In our cohorts with advanced age the 1‐year follow‐up eGFR was similar in both groups.
Despite increased co‐morbidity in the RCC group there was no increased decline in renal function.
Only reduced preoperative eGFR could be identified as risk factor for developing a postoperative eGFR of <60 mL/min/1.73 m2.
Radiofrequency ablation (RFA) of renal cell carcinoma (RCC): experience in 200 tumours
Authors: Wah Tze M. , Irving Henry C. , Gregory Walter , Cartledge Jon , Joyce Adrian D. , Selby Peter J. 
Published: July 2013

Objectives
To evaluate our clinical experience with percutaneous image‐guided radiofrequency ablation (RFA) of 200 renal tumours in a large tertiary referral university institution.
Patients and Methods
Image‐guided RFA (ultrasonography or computed tomography [CT]) of 200 renal tumours in 165 patients from June 2004 to 2012 was prospectively evaluated. Institutional Review Board approval was granted.
The treatment response and technical success were defined by absence of contrast enhancement within the tumour on contrast enhanced CT or magnetic resonance imaging.
Both major and minor complications, glomerular filtration rate (GFR) before and after RFA, the management and outcomes of the complications, as well as oncological outcome were prospectively documented.
Multivariate analysis was used to determine variables associated with major complications and also the percentage GFR change after RFA.
The overall (OS), 5‐year cancer‐specific (CSS), local recurrence‐free (LRFS) and metastasis‐free survival (MFS) rates are presented using the Kaplan–Meier curves.
Results
In all, 200 tumours were RF ablated with a mean (range) tumour size of 2.9 (1–5.6) cm and the mean (range) patient age was 67.7 (21–88.6) years with a mean follow‐up period of 46.1 months. The primary technical and overall technical success rate was 95.5% and 98.5%, respectively. Two independent predictors of successful RFA in a single sitting were tumour size (<3 cm) and exophytic location in multivariate logistic regression analysis.
Major complications included ureteric injury (six patients), calyceal‐cutaneous fistula (one), acute tubular necrosis (one) and abscess (two). Two independent predictors of ureteric injury were central location and lower pole position.
Within this cohort of patients, only four patients developed significant renal function deterioration i.e. >25% decreased in GFR. In all, 161 (98%) patients of the 165 patients have preservation of renal function. Any change in renal function after RFA was not influenced by tumour factors or solitary kidney status.
In our clinical series, this yielded a 5‐year OS, CSS, LRFS and MFS rates of 75.8%, 97.9%, 93.5% and 87.7% respectively.
Conclusions
Image‐guided RFA is a safe, nephron sparing and effective treatment for small renal cell carcinoma (RCC) tumours with a low rate of recurrence and has good 5‐year CSS and MFS rates.
Climate‐driven generation of a fluvial sheet sand body at the Paleocene–Eocene boundary in north‐west Wyoming (USA)
Authors: Foreman B. Z. 
Published: July 2013

AbstractAn unusually thick and laterally persistent fluvial sand body crops out at the Paleocene–Eocene boundary within the northern part of the Bighorn Basin in northwest Wyoming, USA. The generation of this ‘Boundary Sandstone’ was previously ascribed to a period of reduced subsidence; however, a new carbon isotope record presented herein shows it to be intimately correlated to the Paleocene–Eocene Thermal Maximum (PETM), an extreme global warming event ca. 56 Ma. This study evaluates the impacts of the PETM on fluvial deposition in the basin by integrating sedimentological data with geochemical, palaeoichnological, and palaeobotanical proxy records. Compared to pre‐ and post‐PETM fluvial sand bodies, the Boundary Sandstone is more highly amalgamated, both vertically and laterally, but shows no changes in lithofacies associations, palaeodispersal directions, palaeoflow depths, or palaeochannel widths. At its thickest, the Boundary Sandstone resides entirely within the main body of the PETM, an ca. 113 kyr time interval when global pCO2 levels and temperatures were at their highest, and local mean annual rainfall low, floodplains well drained and vegetation comparatively sparse. The totality of data sets imply that the Boundary Sandstone is related to the preferential removal of fine‐grained floodplain deposits by either: (i) rapid readjustments in river gradients related to documented short‐term precipitation oscillations or (ii) reductions in the cohesiveness of overbank sediments related to decreased rooting density and water table fluctuations. Hence, short‐term climate perturbations may manifest within large‐scale depositional patterns in ways ostensibly like tectonics.
Synthesis, Antibacterial Activities, and 3D‐QSAR of Sulfone Derivatives Containing 1, 3, 4‐Oxadiazole Moiety
Authors: Li Pei , Yin Juan , Xu Weiming , Wu Jian , He Ming , Hu Deyu , Yang Song , Song Baoan 
Published: July 2013

A series of sulfone derivatives containing 1, 3, 4‐oxadiazole moiety were prepared and evaluated for their antibacterial activities by the turbidimeter test. Most compounds inhibited growth of Ralstonia solanacearum (R. solanacearum) from tomato and tobacco bacterial wilt with high potency, among which compounds 5a and 5b exhibited the most potent inhibition against R. solanacearum from tomato and tobacco bacterial wilts with EC50 values of 19.77 and 8.29 μg/mL, respectively. Our results also demonstrated that 5a, 5b, and a number of other compounds were more potent than commercial bactericides Kocide 3000 and Thiodiazole Copper, which inhibited R. solanacearum from tomato bacterial wilt with EC50 values of 93.59 and 99.80 μg/mL and tobacco bacterial wilt with EC50 values of 45.91 and 216.70 μg/mL, respectively. The structure–activity relationship (SAR) of compounds was studied using three‐dimensional quantitative structure–activity relationship (3D‐QSAR) models created by comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) based on compound bioactivities against tomato and tobacco bacterial wilts. The 3D‐QSAR models effectively predicted the correlation between inhibitory activity and steric–electrostatic properties of compounds.
Live anatomy of the perineal body in patients with third‐degree rectocele
Authors: Wagenlehner F. M. E. , Del Amo E. , Santoro G. A. , Petros P. 
Published: July 2013

AbstractAimIn many pelvic floor disorders, the perineal body is damaged or destroyed. There is still a considerable variation in anatomical descriptions of the perineal body and even more debate with regard to its attachments and relationships. Cadaveric dissections do not always reflect the functional behaviour of structures in the pelvis and description of live anatomy on imaging studies is not always reliable. This study aimed to define the anatomy of the perineal body in patients with rectocele during the live dissection required for minimally invasive surgical repair.MethodFrom January 2007 to December 2009 consecutive patients requiring surgery for third‐degree rectocele and symptoms of obstructed defaecation were recruited. Participants underwent dissection of the perineal body, rectum and vagina preliminary to a tissue fixation system, an operation which inserts a tensioned tape to repair the perineal body.ResultsThirty Caucasian female patients, mean age 61 (range 47–87) years, mean parity 2.6 (range 1–5), were included. Live dissection demonstrated that the perineal body was divided into two parts, joined by a stretched central part, anchored laterally by the deep transverse perineii muscle to the descending ramus of the pubic bone. The mean longitudinal length of the perineal body was 4.5 (3.5–5.5) cm, accounting for 50% of the posterior vaginal support.ConclusionIn women with low rectocele, the perineal body appears to be divided into two parts, severely displaced behind the ischial tuberosities.
Cultural Diversity, Innovation, and Entrepreneurship: Firm‐level Evidence from London
Authors: Nathan Max , Lee Neil 
Published: July 2013

AbstractA growing body of research is making links between diversity and the economic performance of cities and regions. Most of the underlying mechanisms take place within firms, but only a handful of organization‐level studies have been conducted. We contribute to this underexplored literature by using a unique sample of 7,600 firms to investigate links among cultural diversity, innovation, entrepreneurship, and sales strategies in London businesses between 2005 and 2007. London is one of the world's major cities, with a rich cultural diversity that is widely seen as a social and economic asset. Our data allowed us to distinguish owner/partner and wider workforce characteristics, identify migrant/minority‐headed firms, and differentiate firms along multiple dimensions. The results, which are robust to most challenges, suggest a small but significant “diversity bonus” for all types of London firms. First, companies with diverse management are more likely to introduce new product innovations than are those with homogeneous “top teams.” Second, diversity is particularly important for reaching international markets and serving London's cosmopolitan population. Third, migrant status has positive links to entrepreneurship. Overall, the results provide some support for claims that diversity is an economic asset, as well as a social benefit.
Trapping ofEuropean buprestid beetles in oak forests using visual and olfactory cues
Authors: Domingue Michael J. , Imrei Zoltán , Lelito Jonathan P. , Muskovits József , Janik Gergely , Csóka György , Mastro Victor C. , Baker Thomas C. 
Published: July 2013

AbstractTrapping approaches developed for the emerald ash borer (EAB),Agrilus planipennisFairmaire (Coleoptera:Buprestidae), were adapted for trapping severalEuropean oak buprestid species. These approaches included the use of natural leaf surfaces as well as green and purple plastic in sticky trap designs. Plastic surfaces were incorporated into novel ‘branch‐trap’ designs that each presented two 5 × 9‐cm2rectangular surfaces on a cardboard structure wrapped around the leaves of a branch. We used visual adultAgrilusdecoys in an attempt to evoke male mating approaches toward the traps. Our first experiment compared the attractiveness of visual characteristics of the surfaces of branch‐traps. The second looked at the effect on trap captures of adding semiochemical lures, including manuka oil, (Z)‐3‐hexen‐1‐ol, and (Z)‐9‐tricosene. In total, 1 962 buprestid specimens including 14 species from the genusAgriluswere caught on 178 traps in a 22‐day time‐span. Overall, the green plastic‐covered branch‐traps significantly out‐performed the other trap designs. We further found that the presence of anEABvisual decoy placed on the trap surface often increased captures on these green traps, but this effect was stronger for certainAgrilusspecies than for others. The visual decoy was particularly important for the most serious pest detected,Agrilus biguttatusFabricius, which was captured 13 times on traps with decoys, but only once without a decoy. There were some small but significant effects of odor treatment on the capture of buprestids of two common species,Agrilus angustulusIlliger andAgrilus sulcicollisLacordaire. There were also 141Elateridae specimens on these traps, which were not influenced by trap type or decoys. The results suggest that small branch‐traps of this nature can provide a useful new tool for monitoring of buprestids, which have the potential to be further optimized with respect to visual and olfactory cues.
The effect of exercise on plasma concentrations of inflammatory markers in normal and previously laminitic ponies
Authors: Menzies‐Gow N. J. , Wray H. , Bailey S. R. , Harris P. A. , Elliott J. 
Published: July 2013

SummaryReasons for performing studyThe mechanisms underlying predisposition to pasture‐associated laminitis remain unclear; chronic inflammation is implicated, and this may be exacerbated by physical inactivity.ObjectivesTo determine whether exercise affects the inflammatory profile of normal and previously laminitic ponies.Study designProspective case–control study.MethodsThe short (1 day) and longer term (14 days) effects of low intensity (10 min walking and 5 min trotting) exercise on plasma inflammatory marker concentrations in normal (NL) and previously laminitic (PL) nonobese ponies (n = 6/group) was determined. Plasma concentrations ofTNF‐α, serum amyloid A (SAA), haptoglobin, insulin, adiponectin and fibrinogen were assayed by validated/standard methods. Data were analysed using a linear mixed effects model.ResultsBefore exercise, plasma [adiponectin] was significantly (P = 0.0001) lower inPL(mean ± s.d. 2.4 ± 0.1 ng/l) than inNL(4.03 ± 0.2 ng/l), but exercise had no effect. Previous laminitis and exercise had no effect on plasma [TNF‐α] or [fibrinogen]. Serum amyloid A concentrations in all ponies were significantly (P = 0.00001) reduced after longer term exercise compared to Day 1 values. Plasma [haptoglobin] was significantly (P = 0.00001) higher inPLcompared toNLon Day 1. This difference was no longer apparent after longer term exercise, such that [haptoglobin] inPLhad decreased to concentrations similar toNL. Following short‐term exercise, all ponies had an initial decrease in serum [insulin] immediately after exercise, followed by an increase peaking 10 min after exercise cessation, before returning to pre‐exercise values. On Day 14 these fluctuations were significantly (P = 0.001) reduced in all ponies.ConclusionsFourteen days of low intensity exercise significantly decreased [SAA] in all ponies and plasma [haptoglobin] inPLsuch that it was no longer increased compared toNL. Regular low intensity exercise appears to have an anti‐inflammatory effect, which is possibly greater inPLand so may be beneficial in reducing this putative risk factor in pasture‐associated laminitis.
Ageing and colony‐forming efficiency of human hair follicle keratinocytes
Authors: Lecardonnel Jennifer , Deshayes Nathalie , Genty Gaïanne , Parent Nathalie , Bernard Bruno A. , Rathman‐Josserand Michelle , Paris Maryline 
Published: July 2013

AbstractThe decline of tissue regenerative potential of skin and hair is a hallmark of physiological ageing and may be associated with age‐related changes in tissue‐specific stem cells and/or their environment. Human hair follicles (hHF) contain keratinocytes having the property of stem cells such as clonogenic potential. Growth capacity of hHF keratinocytes shows that most of the colony‐forming cells are classified as holoclones, meroclones or paraclones when analysed in a clonal assay (Cell, Volume 76, page 1063). Despite the well‐known impact of ageing on human hair growth, little is known about changes in hHF keratinocyte clonogenic potential with age. This study aimed at assessing the clone‐forming efficiency (CFE) of hHF keratinocytes from three age groups of human donors. It demonstrates that ageing affects hHF keratinocyte CFE.
Management of hypertension in adults: the 2013 French Society of Hypertension guidelines
Authors: Blacher Jacques , Halimi Jean‐Michel , Hanon Olivier , Mourad Jean‐Jacques , Pathak Atul , Schnebert Bruno , Girerd Xavier ,   the French Society of Hypertension
Published: July 2013

AbstractTo improve the management of hypertension in the French population, the French Society of Hypertension has decided to issue a new set of guidelines that include the following practical characteristics: usefulness for clinical practice, short, easy‐to‐read format, comprehensive writing for non‐physicians, wide dissemination among healthcare professionals and the hypertensive population, assessment of their impact among healthcare professionals and with regard to public health goals. These guidelines, so‐called the appointments of the hypertensive patient, include 15 recommendations, divided into three chapters, according to the timing of the medical management: prior to treatment initiation, the initial treatment plan (first 6 months) and the long‐term care plan (beyond 6 months). We hope that a vast dissemination of these simple guidelines will help to improve hypertension control in the French population from 50% to 70%, an objective expected to be achieved in 2015 in France.
Serum albumin level is a notable profiling factor for non‐B, non‐C hepatitis virus‐related hepatocellular carcinoma: A data‐mining analysis
Authors: Yamada Shingo , Kawaguchi Atsushi , Kawaguchi Takumi , Fukushima Nobuyoshi , Kuromatsu Ryoko , Sumie Shuji , Takata Akio , Nakano Masahito , Satani Manabu , Tonan Tatsuyuki , Fujimoto Kiminori , Shima Hiroji , Kakuma Tatsuyuki , Torimura Takuji , Charlton Michael R. , Sata Michio 
Published: July 2013

AimVarious factors are underlying for the onset of non‐B, non‐C hepatitis virus‐related hepatocellular carcinoma (NBNC‐HCC). We aimed to investigate the independent risk factors and profiles associated with NBNC‐HCC using a data‐mining technique.MethodsWe conducted a case‐control study and enrolled 223 NBNC‐HCC patients and 669 controls from a health checkup database (n = 176 886). Multivariate analysis, random forest analysis and a decision‐tree algorithm were employed to examine the independent risk factors, factors distinguishing between the case and control groups, and to identify profiles for the incidence of NBNC‐HCC, respectively.ResultsIn multivariate analysis, besides γ‐glutamyltransferase (GGT) levels and the Brinkman index, albumin level was an independent negative risk factor for the incidence of NBNC‐HCC (odds ratio = 0.67; 95% confidence interval = 0.60–0.70; P < 0.0001). In random forest analysis, serum albumin level was the highest‐ranked variable for distinguishing between the case and control groups (98 variable importance). A decision‐tree algorithm was created for albumin and GGT levels, the aspartate aminotransferase‐to‐platelet ratio index (APRI) and the Brinkman index. The serum albumin level was selected as the initial split variable, and 82.5% of the subjects with albumin levels of less than 4.01 g/dL were found to have NBNC‐HCC.ConclusionData‐mining analysis revealed that serum albumin level is an independent risk factor and the most distinguishable factor associated with the incidence of NBNC‐HCC. Furthermore, we created an NBNC‐HCC profile consisting of albumin and GGT levels, the APRI and the Brinkman index. This profile could be used in the screening strategy for NBNC‐HCC.
Using iterated local search for solving the flow‐shop problem: Parallelization, parametrization, and randomization issues
Authors: Juan Angel A. , Lourenço Helena R. , Mateo Manuel , Luo Rachel , Castella Quim 
Published: July 2013

AbstractIterated local search (ILS) is a powerful framework for developing efficient algorithms for the permutation flow‐shop problem (PFSP). These algorithms are relatively simple to implement and use very few parameters, which facilitates the associated fine‐tuning process. Therefore, they constitute an attractive solution for real‐life applications. In this paper, we discuss some parallelization, parametrization, and randomization issues related to ILS‐based algorithms for solving the PFSP. In particular, the following research questions are analyzed: (a) Is it possible to simplify even more the parameter setting in an ILS framework without affecting performance? (b) How do parallelized versions of these algorithms behave as we simultaneously vary the number of different runs and the computation time? (c) For a parallelized version of these algorithms, is it worthwhile to randomize the initial solution so that different starting points are considered? (d) Are these algorithms affected by the use of a “good‐quality” pseudorandom number generator? In this paper, we introduce the new ILS‐ESP (where ESP is efficient, simple, and parallelizable) algorithm that is specifically designed to take advantage of parallel computing, allowing us to obtain competitive results in “real time” for all tested instances. The ILS‐ESP also uses “natural” parameters, which simplifies the calibration process. An extensive set of computational experiments has been carried out in order to answer the aforementioned research questions.
Evaluation of mixed‐model U‐line operational designs
Authors: Hong Yunsook , Visich John K. , Pinto Peter A. , Khumawala Basheer M. 
Published: July 2013

AbstractOften in lean manufacturing, multiple products are produced in U‐shaped manufacturing cells to simultaneously achieve product variety and production efficiency. We examine two design issues for mixed‐model U‐lines: work rules (a first‐come‐first‐serve rule and a crossover‐and‐return rule) and inventory flow choices (direct flow and buffered flow). Simulation results indicated that throughput and labor utilization can be improved by implementing a “buffer” with the first‐come‐first‐serve rule. Interestingly, the effectiveness of an inventory flow choice was dependent on the work rule (interaction effect), and relationships among performance dimensions differed across the designs.