bluuebunny/crossref_metadata_2025_split huggingface dataset:
Celastrol Derivative/DOX Co-Assembled Nanodrug for Enhanced Antitumor Therapy
Authors: Su Jiangtao , Chen Xue , Ye Fan , Liu Chuchu , Liang Jiahao , Zhang Xuejun , Guo Xiaoxia 
Published: August 2024

Background:
Multidrug resistance (MDR) is a key challenge in clinical chemotherapy.
The combination of drugs can effectively reverse multi-drug resistance.

Objective:
In this study, doxorubicin (DOX) was capsulated into nanoparticles formed by an amphiphilic
PEGylated-poly (α-lipoic acid)-methanamide analogue of celastrol (mPEG-PαLA-CEN)
prodrug polymer. CEN was linked to the branched chain of poly (α-lipoic acid) by forming ester
bonds. DOX was physically trapped inside the nanoparticles via electrostatic interaction. Both
drugs can be simultaneously released in response to low pH and high GSH in order to overcome
DOX resistance.

Methods:
The chemical structure of the mPEG-PαLA-CEN-DOX NPs was confirmed through 1H
NMR, FT-IR spectroscopy, UV-Vis spectrum, DLS, and TEM. Drug-loading content, efficacy,
and drug release were measured using HPLC. Cell toxicity was examined using an MTT assay.

Results:
CEN/DOX-loaded nanoparticles were found to have spherical shapes with diameters of
around 229.7 nm. The NPs exhibited high biocompatibility and released 92% DOX and 71.8%
CEN in response to low pH and high GSH of tumor microenvironments. As dual drug-loaded
nanoparticles, the efficacy of mPEG-PαLA-CEN-DOX NPs against tumor cell lines in vitro was
enhanced for both MCF-7 and MCF-7/ADR compared to free DOX. Compared to free DOX, the
IC50 of mPEG-PαLA-CEN-DOX NPs reduced from 46.10 μM to 8.36 μM for the MCF-7/ADR
cell line.

Conclusion:
In conclusion, this study demonstrated that PEGylated poly (α-lipoic acid)-CEN
copolymers can be used not only as biocompatible, stimulation-responsive anticancer drug nanocarriers
but also as chemosensitizers to overcome multidrug resistance, which provide a theoretical
base for clinical application of CEN/DOX nanodrug.
Harnessing Natural Resources for Advancements in Dengue Virus Treatment
Authors: Amin Hapis Nur Aina Najiha , Rashid Nurshamimi Nor , Choo Yeun-Mun 
Published: August 2024

:
Dengue fever, caused by the Dengue virus (DENV) and transmitted by Aedes aegypti
mosquitoes, has become endemic in over 100 countries. Despite considerable research, there is a
lack of specific drugs for clinical use against dengue. Hence, further exploration to identify antidengue
compounds is essential. In recent years, natural products have gained attention for their antiviral
properties. Plant-based medicines are particularly appealing due to their safety and low
toxicity. This review summarizes natural compounds with potential antiviral activity against
DENV, highlighting their mechanisms of action. Various compounds, from traditional herbal
remedies to novel plant isolates, show promise against dengue, targeting crucial viral proteins like
the envelope protein, proteases, and RNA polymerase. Exploring natural sources of antiviral
agents against dengue is crucial. These compounds offer hope for effective treatments and mitigating
dengue's global impact.
Simultaneous Qualitative and Quantitative Determination of 33 Compounds from Rubus Alceifolius Poir Leaves Using UHPLC-Q-Orbitrap-MS/MS
Analysis
Authors: Li Xican , Zeng Jingyuan , Li Chunhou , Chai Hanxiao , Chen Shaoman , Jin Nana , Chen Tingshan , Lin Xiaohua , Khan Sunbal , Cai Rongxin 
Published: August 2024

Background:
Rubus alceifolius Poir leaves are a widely distributed medicinal plant material
in the Eastern Hemisphere. However, there has been no report regarding their chemistry until
now.

Methods:
Fresh R. alceifolius leaves were treated using a set of experimental protocols to prepare a
lyophilized aqueous extract. Subsequently, the extract was qualitative and quantitatively analyzed
using the database-affinity ultra-high-performance liquid chromatography-quadrupole-Exactive-
Orbitrap-tandem mass spectrometry (UHPLC-Q-Exactive-Orbitrap-MS/MS) technology.

Results:
Based on MS/MS elucidation and comparison with the database in UHPLC-Q-Exactive-
Orbitrap-MS/MS apparatus, 33 compounds were qualitatively identified. Especially, 12 isomers were
strictly distinguished, including apigenin vs. 2'-hydroxydaidzein, luteolin 7-O-glucuronide vs. scutellarin,
(+) catechin vs. (-) epicatechin, 3-O-caffeoylquinic acid vs. 4-O-caffeoylquinic acid vs. 5-Ocaffeoylquinic
acid, and 3,4-O-dicaffeoylquinic acid vs 3,5-O-dicaffeoylquinic acid vs 4,5-Odicaffeoylquinic
acid. In addition, 21 non-isomeric compounds, such as ellagic acid and gallic acid,
were also found under negative or positive ion models. The quantitative analysis suggested that ellagic
acid was found to be of the highest level (133.00 ± 3.50 μg/g), while (+)-4-cholesten-3-one was
calculated to be of the lowest level (0.035 ± 0.0050 μg/g).

Conclusion:
These findings will help to understand the substance basis of the traditional medicinal
functions of R. alceifolius leaves and to find their suitable quality markers.
Characterization of Antibiotic Actinomycin D Isolated from Streptomyces parvulus Collected from Marine Sponge of Barrang Lompo Island, Makassar, Indonesia
Authors: Rante Herlina , Alam Gemini , Bayu Murti Yosi , Ali Alimuddin 
Published: August 2024

Background:
Microorganisms associated with sea sponges have proven to be good natural product resources that are biologically active and pharmaceutically important.

Objective:
This research aimed to identify actinomycetes related to a sponge from Bar-ranglompo Island Makassar and the antibacterial compounds.

Methods:
Identification of actinomycetes was based on molecular characterization of sequence gen16S rRNA. The antibacterial compound was separated using vacuum liquid chromatog-raphy and preparative Thin Layer Chromatography (TLC). The structure determination was done based on spectroscopy 1H-NMR, 13C-NMR, 2D NMR, and mass spectra.

Results:
Molecular characterization showed that actinomycetes strain BLP 20 had the closest relationship with Streptomyces parvulus and Uncultured Streptomyces sp. with a similarity value of 83%. The results obtained from the characterization of antibacterial compounds based on spectroscopic data indicate that these compounds lead to Actinomycin D.

Conclusion:
Characterization and identification of Strain 20 / BLP by molecular phylogenetic analysis of 16S rRNA sequences revealed the closest relationship with Uncultured Streptomy-ces sp and S. parvulus with a similarity value of 83 %, which indicated a new species. The structure of the active compound isolated from actinomycetes strain 20 / BLP leads to Actino-mycin D.
Blood Pressure Estimation from Wavelet Scalogram of PPG signals using Convolutional Neural Networks
Authors: Maharajan Ramakrishnan 
Published: August 2024

Introduction
In this work, calibration-free blood pressure estimation using wavelet scalograms of PPG signals using Convolutional Neural Network (CNN) has been proposed. The PPG signal, easily obtained from a subject, serves as a reliable indicator for predicting blood pressure (BP).

Methods
The proposed methodology involves employing Continuous Wavelet Transform (CWT) scalograms of the PPG signal as inputs for the CNN. Two distinct architectures for BP estimation are explored: one employing regression with a fully connected neural network and another utilizing CNN with Support Vector Regression (SVR).

Results
The results demonstrate superior BP estimation with the CNN-SVR architecture. With the CNN-SVR model, the Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) are estimated with a Root Mean Square Error (RMSE) of 6.7 mmHg and 8.9 mmHg, respectively.

Conclusion
The proposed CNN-SVR model gives 52% better estimation error performance in SBP estimation compared to a machine learning model reported in a previous work.
Left Ventricular Wall Motion as an Additional Valuable Parameter in Diabetic Patients with Normal Myocardial Perfusion Imaging
Authors: Davari Amirhesam , Jalali-zefrei Fatemeh , Gholami-chabok Bahareh , Tabaghi Shiva , Farzipour Soghra , Delpasand Kourosh , Mousavi Seyed Mehdi 
Published: August 2024

Background:
Gated SPECT is an established technique for assessment of left ventricular
function in cardiovascular disease patients. However, there is little information about the influence
of diabetes mellitus on gated SPECT parameters. This study was established to assess gated
SPECT parameters in Diabetes Mellitus (DM) and non-diabetes mellitus (non-DM) patients with
normal Myocardial Perfusion Imaging (MPI).

Methods:
In this analytical cross-sectional study, 314 patients (157 DM, 157 non-DM) with normal
MPI were enrolled. Prevalence of risk factors for CAD like hypertension (HTN), and dyslipidemia
were found to be significantly higher (p <0.01) in DM patients compared to non-DM.

Results:
No statistically significant difference was observed among the TID, ESV, EDV, PFR,
TTPF, and Wall Thickness (WT) parameters between DM and non-DM patients. Wall motion
(Wm) in DM patients was significantly higher compared to non-DM patients. (3.9 ± 0.51 vs. 2.69
± 0.48 for DM and non-DM patients, respectively, p-value:0.01). Also, there was no significant
difference in Wm in the two groups with and without HTN. This shows the independent effect of
DM on the Wm.

Conclusion:
This study believes that the Wm parameter should be noted for the early diagnosis or
prevention of heart disease in DM patients. These findings can indicate the gradual changes in the
movements of the left ventricle and the beginning of the progression of diabetic cardiomyopathy.
Study on Fingerprint and Multiple Indicators for Quantitative Detection Method Development in Powdered Milk Thistle Extract
Authors: Lan Tao , Zhang Wenyu , Zhou Qi , Huang Jinli , Wu Qi , Yu Congcong , Luo Shihui , Zhao Xi , He Ruikun 
Published: August 2024

Introduction:
Silymarins are the main active ingredient in milk thistle extract, reflecting
the quality of extract products. The detection methods for silymarins in different pharmacopoeia
standards may vary, which may lead to inconsistent detection results.

Method:
Due to the lack of research on related fingerprint spectra, its qualitative work is hard to
carry out. Hence, based on existing standard methods, an HPLC method was established by optimizing
the gradient program of the mobile phase.

Results:
The effectiveness of this method and the fingerprint was also studied. The similarity of 31
batches of samples ranged from 0.791 to 1.000, indicating the characteristic spectrum formed can be
well used for qualitative analysis.

Conclusion:
Under optimal analytical conditions, the six silymarin compounds in the samples can
achieve good baseline separation from the matrix with good resolution. At the same time, the LOD
was 25 mg/kg, and the recovery rates at three levels ranged from 92% to 108%, with RSDs less than
4%. The fingerprint spectrum and content determination method established in this study had good
repeatability and high accuracy, which can provide a new method for quality control of milk thistle
extract.
ANALISIS KESENJANGAN PROSES BISNIS DENGAN BLUEPRINT IMPLEMENTASI SISTEM ENTERPRISE RESOURCE PLANNING (ERP)
Authors: Bagaskara Wahyu Fahmi , Anggraeni Rila 
Published: August 2024

Mendekorumah is a small medium enterprise, engaged in furniture and interior design, and production by make to order. The problems process of distribution information SME’s with business activities conducted manually. An information system can help the industry SME’s in improving the effectiveness of the activities of companies is the enterprise resource planning. The research purposes is to be able to implement ERP for SME’s Mendekorumah so that the problems faced can be resolved. The type of research used is descriptive qualitative method, data analysis methods data obtained from interviews, field notes and documents. In the results, in Mendekorumah it was found that automatic records such as business partner master data, product master data recording, running business processes.Mendekorumah has not implemented the ERP system, the blueprint used to find out changes in business processes later when implemented next step. The gaps found in business processes between the ERP implementation blueprint and current business processes Mendekorumah updated business processes by implementing an ERP system for recording all activities and further modernizing business processes.
Pengaruh Hedonic Shopping Motivation dan Shopping Lifesytle Terhadap Impulse Buying Melalui Positive Emotion
Authors: Rabbani M Rizki , Wijayanto Gatot , Novrianti Dian Puspita 
Published: August 2024

This study aims to analyze the effect of Hedonic Shopping Motivation and Shopping Lifestyle on Impulse Buying through Positive Emotion on H&M consumers in Pekanbaru. The data collection technique in this research is literature study and questionnaires. The population in this study were H&M consumers in Pekanbaru. The number of samples taken in this study were 384 samples. The sampling method used in this study is non-probability sampling using the accidental sampling technique. The data processed using the SEM-PLS method with SmartPLS 3.0 software. The results of this study indicate that Hedonic Shopping Motivation has an effect on Positive Emotion, Shopping Lifestyle has an effect on Positive Emotion, Positive Emotion has an effect on Impulse Buying, Hedonic Shopping Motivation has no effect on Impulse Buying, Shopping Lifestyle has an effect on Impulse Buying, Hedonic Shopping Motivation affects Impulse Buying through Positive Emotion, and Shopping Lifestyle affects Impulse Buying through Positive Emotion.

Abstrak
Penelitian ini bertujuan untuk menganalisis pengaruh Hedonic Shopping Motivation dan Shopping Lifestyle terhadap Impulse Buying melalui Positive Emotion pada konsumen H&M di Pekanbaru. Teknik pengumpulan data dalam penelitian ini adalah studi pustaka dan kuesioner. Populasi dalam penelitian ini adalah konsumen H&M di Pekanbaru. Jumlah sampel yang diambil dalam penelitian adalah 384 sampel. Metode pengambilan sampel yang digunakan dalam penelitian ini adalah non-probability sampling dengan menggunakan teknik accidental sampling. Pengolahan data menggunakan metode SEM-PLS dengan software SmartPLS 3.0. Hasil penelitian ini menunjukkan bahwa Hedonic Shopping Motivation berpengaruh terhadap Positive Emotion, Shopping Lifestyle berpengaruh terhadap Positive Emotion, Positive Emotion berpengaruh terhadap Impulse Buying, Hedonic Shopping Motivation tidak berpengaruh terhadap Impulse Buying, Shopping Lifestyle berpengaruh terhadap Impulse Buying, Hedonic Shopping Motivation memengaruhi Impulse Buying melalui Positive Emotion, dan Shopping Lifestyle memengaruhi Impulse Buying melalui Positive Emotion.
Pengaruh Product Quality, Service Quality, dan Perceived Value terhadap Repurchase Intention
Authors: Hanggara Darma Kusuma , Hussein Ananda Sabil 
Published: August 2024

The objective of this research is to assess and analyze the effects of product quality, service quality, and perceived value on the intention to purchase culinary products at the Lowokwaru branch of Nakoa Café Suhat in Malang. This study is categorized as explanatory research since it explains the positions of the examined variables and the effects of one variable to others. The data was harvested from questionnaires distributed to 150 samples and was analyzed using multiple linear regression in SPSS 25. This study finds that product quality has no significant influence on the repurchase intention, that service quality significantly affects the repurchase intention, that perceived value has a significant influence on the repurchase intention, and that product quality service quality, and perceived value simultaneously have significant effects on the repurchase intention.

Abstrak
Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh product quality, service quality, dan perceived value terhadap repurchase intention pada kuliner di Nakoa Cafe Suhat cabang Lowokwaru, Malang. Jenis penelitian ini adalah explanatory research yang menjelaskan kedudukan pada variabel-variabel yang diteliti serta pengaruh antara variabel satu dengan variabel lainnya. Sampel penelitian ini adalah konsumen Nakoa Cafe Suhat cabang Lowokwaru, Malang dengan jumlah sampel yang dikumpulkan dan berhasil dianalisis sebanyak 150 responden. Data dikumpulkan menggunakan kuesioner. Analisis data yang dilakukan menggunakan analisis regresi linier berganda menggunakan SPSS 25. Hasil penelitian menunjukkan bahwa product quality tidak berpengaruh signifikan terhadap repurchase intention, bahwa service quality berpengaruh signifikan terhadap repurchase intention, bahwa perceived value berpengaruh signifikan terhadap repurchase intention, dan bahwa product quality, service quality, dan perceived value secara simultan berpengaruh signifikan terhadap repurchase intention.
Analisis Tingkat Kepuasan Pelanggan Terhadap Transaksi Nontunai Pada Usaha Makanan Dan Minuman
Authors: Savira Dilla , Rahayu Deny Danar , Wasnury Rendra 
Published: August 2024

This study aims to determine the level of Customer Satisfaction and indicators that deserve attention regarding QRIS non-cash transactions in food and beverage businesses in Pekanbaru City. The population in this study included people in Pekanbaru City who had used QRIS as a payment method in the food and beverage business by taking samples using a purposive sampling technique with a total sample of 120 respondents. Data analysis used in this study is the Customer Satisfaction Index (CSI) and Importance Performance Analysis (IPA). From the results of calculations with CSI, a value of 81.62% was obtained and entered into the very satisfied category. The IPA results show that there are nine indicators whose performance needs to be maintained and six indicators that need to be considered for improvement to increase Customer Satisfaction with QRIS non-cash transactions in food and beverage businesses in Pekanbaru City.

Abstrak
Penelitian ini bertujuan untuk mengetahui Tingkat Kepuasan Pelanggan dan indikator yang patut untuk diperhatikan terkait transaksi nontunai QRIS pada usaha makan dan minuman di Kota Pekanbaru. Populasi dalam penelitian meliputi masyarakat di Kota Pekanbaru yang pernah menggunakan QRIS sebagai metode pembayaran pada usaha makanan dan minuman dengan pengambilan sampel menggunakan teknik purposive sampling dengan jumlah sampel sebanyak 120 responden. Analisis data yang digunakan pada penelitian ini adalah Customer Satisfaction Index (CSI) dan Importance Perfomance Analysis (IPA). Dari hasil perhitungan dengan CSI diperoleh nilai sebesar 81,62% dan masuk kedalam kategori sangat puas. Hasil IPA menunjukkan terdapat sembilan indikator yang perlu dipertahankan kinerjanya dan enam indikator yang perlu dilakukan pertimbangan peningkatan untuk meningkatkan Kepuasan Pelanggan terhadap transaksi nontunai QRIS pada usaha makanan dan minuman di Kota Pekanbaru.
Efektivitas E-Wom, Store Atmosphere, Dan Price Dalam Mempengaruhi Purchase Intention
Authors: Ikraam Mochammad Nibraas Faalih 
Published: August 2024

Purchase intention is an important issue to study in various industrial fields at this time, especially the tourism industry, especially restaurant industry. Purposes of this research is to determine the influence of electronic word of mouth (e-WOM), store atmosphere and price on purchase intention at Concrete Cafe. This type of research is quantitative with a population of all potential Concrete Cafe consumers, because the population size is unknown and its nature is dynamic, the sample size was determined using the Lameshow formula and 100 respondents were obtained. The data is primary data collected using a questionnaire. The data was then analyzed using multiple linear regression with the help of SPSS 25. The research results showed that E-Wom on Instagram and Tik-Tok social media did not have a significant effect on Concrete consumers' Purchase Intention. Store Atmosphere and Price have a positive and significant effect on Purchase Intention of Stone Concrete consumers. There is a simultaneous influence (together) of E-Wom, Store Atmosphere, and Price on the Purchase Intention of Concrete Cafe Batu consumers.

Abstrak
Purchase intention menjadi isu yang penting untuk dikaji di berbagai bidang industri pada saat ini, khususnya industri pariwisata yaitu industri restoran. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh electronic word of mouth (e-wom), store atmosphere dan harga berpengaruh terhadap purchase intention pada Concrete Cafe. Jenis penelitian ini Kuantitatif dengan populasi seluruh calon konsumen Concrete Cafe, karena jumlah populasi tidak diketahui dan sifatnya dinamis maka penentuan jumlah sampel ditentukan dengan rumus Lameshow dan didapat 100 responden. Data merupakan data primer yang dikumpulkan dengan kuisioner. Data kemudian dianalisa dengan regresi linier berganda dengan bantuan SPSS 25. Hasil penelitian menunjukkan E-Wom di Media Sosial Instagram dan Tik-Tok tidak berpengaruh signifikan terhadap Purchase Intention konsumen Concrete. Store Atmosphere dan Price berpengaruh positif dan signifikan terhadap Purchase Intention konsumen Concrete Batu. Terdapat pengaruh secara simultan (bersama-sama) E-Wom, Store Atmosphere, dan Price terhadap Purchase Intention konsumen Concrete Batu.
Analisis Intention to Re-Use Aplikasi yang Ditinjau dari Persepsi Kegunaan dan Persepsi Kemudahan
Authors: Insyira Nabila Khadijah 
Published: August 2024

Intention to reuse is an important indicator for the acceptance of a system or application and their usage continuity. It has two crucial factors: perceived ease of use and perceived usefulness. Perceived usefulness is a perception when users feel the benefit of using a system or application, while perceived ease of use indicates the simplicity and flexibility of the operation of a system or application. The objective of this descriptive research is to analyze and illustrate the effects of perceived usefulness and perceived ease of use on the intention of people in Surabaya to reuse PLN Mobile application. The population is all customers of PLN in Surabaya who have the Customer ID. Unsing nonprobability method and purposive technique, 175 people with the minimum age of eighteen years and have used the application were selected as the respondents. The results of the multiple linear regression show that perceived usefulness and perceived ease of use positively and significantly affect the intention to reuse.

Abstrak
Intention to reuse adalah indikator penting dalam penerimaan suatu sistem atau aplikasi dari niat penggunaan kembali dan aspek kontinuitas penggunaan. Dalam praktiknya intention to use memiliki dua faktor penting yaitu perceived usefulness dan perceived ease of use. Perceived usefulness merupakan persepsi dimana pengguna merasakan adanya manfaat dari suatu sistem atau aplikasi. Perceived ease of use menunjukkan tingkat kemudahan dan fleksibilitas dari penggunaan sistem atau aplikasi. Penelitian ini bertujuan untuk menganalisis dan menjelaskan pengaruh perceived usefulness, dan perceived ease of use terhadap intention to reuse pengguna Aplikasi PLN Mobile di Kota Surabaya. Jenis penelitian ini adalah descriptive analysis. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah non-probability sampling dengan menggunakan metode purposive sampling. Populasi dalam penelitian ini adalah seluruh pelanggan PLN di Kota Surabaya yang tercatat memiliki ID Pelanggan dan diperoleh sampel sebanyak 175 responden dengan kriteria responden minimal berusia 18 tahun dan pernah menggunakan aplikasi PLN Mobile minimal sebanyak satu kali. Penelitian ini menggunakan analisis linier berganda dan hasil penelitian ini menunjukkan bahwa perceived usefulness dan perceived ease of use memiliki pengaruh positif dan signfikan terhadap intention to reuse.