bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fully automated hybrid approach on conventional MRI for triaging clinically significant liver fibrosis: A multi‐center cohort study
Authors: Zha Jun‐hao , Xia Tian‐yi , Chen Zhi‐yuan , Zheng Tian‐ying , Huang Shan , Yu Qian , Zhou Jia‐ying , Cao Peng , Wang Yuan‐cheng , Tang Tian‐yu , Song Yang , Xu Jun , Song Bin , Liu Yu‐pin , Ju Sheng‐hong 
Published: August 2024

AbstractEstablishing reliable noninvasive tools to precisely diagnose clinically significant liver fibrosis (SF, ≥F2) remains an unmet need. We aimed to build a combined radiomics‐clinic (CoRC) model for triaging SF and explore the additive value of the CoRC model to transient elastography‐based liver stiffness measurement (FibroScan, TE‐LSM). This retrospective study recruited 595 patients with biopsy‐proven liver fibrosis at two centers between January 2015 and December 2021. At Center 1, the patients before December 2018 were randomly split into training (276) and internal test (118) sets, the remaining were time‐independent as a temporal test set (96). Another data set (105) from Center 2 was collected for external testing. Radiomics scores were built with selected features from Deep learning‐based (ResUNet) automated whole liver segmentations on MRI (T2FS and delayed enhanced‐T1WI). The CoRC model incorporated radiomics scores and relevant clinical variables with logistic regression, comparing routine approaches. Diagnostic performance was evaluated by the area under the receiver operating characteristic curve (AUC). The additive value of the CoRC model to TE‐LSM was investigated, considering necroinflammation. The CoRC model achieved AUCs of 0.79 (0.70, 0.86), 0.82 (0.73, 0.89), and 0.81 (0.72‐0.91), outperformed FIB‐4, APRI (all p < 0.05) in the internal, temporal, and external test sets and maintained the discriminatory power in G0‐1 subgroups (AUCs range, 0.85–0.86; all p < 0.05). The AUCs of joint CoRC‐LSM model were 0.86 (0.79–0.94), and 0.81 (0.72–0.90) in the internal and temporal sets (p = 0.01). The CoRC model was useful for triaging SF, and may add value to TE‐LSM.
High rates of anal Merkel Cell Polyomavirus and HPV co‐infection among people living with HIV
Authors: Passerini Sara , Fracella Matteo , Benvenuto Domenico , Bugani Ginevra , D'Auria Alessandra , Coratti Eleonora , Babini Giulia , Moens Ugo , Cavallari Eugenio Nelson , Torti Carlo , Antonelli Guido , Ciccozzi Massimo , Pierangeli Alessandra , d'Ettorre Gabriella , Scagnolari Carolina , Pietropaolo Valeria 
Published: August 2024

AbstractKnowledge of Human Polyomavirus (HPyV) infection in the anal area and its association with sexually transmitted infections such as Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) remains limited. Therefore, anal specimens from 150 individuals of both sexes were analyzed for screening purposes. HPV DNA was found in 50.7% of cases, with a predominance of high‐risk (HR) genotypes. HPyV DNA was found in 39.3% of samples, with Merkel Cell Polyomavirus (MCPyV) being the most common, with a higher viral load than JCPyV and BKPyV. In addition, MCPyV viral load increased in people living with HIV (PLWH) with HPV infection (p < 0.0001).
Mean sea level, tidal components and surges in Guanabara Bay (Rio de Janeiro) from 1990 to 2021
Authors: Tecchio Rodrigo , de Souza Danilo Couto , da Silva Matheus Bonjour Laviola , de Oliveria Costa Marcia Carolina , de Camargo Ricardo , Harari Joseph 
Published: August 2024

AbstractGuanabara Bay, located in the Metropolitan Region of Rio de Janeiro, one of the largest urban coastal areas in the Southern Hemisphere, is subject to intense maritime traffic due to the presence of several ports. These facilities are affected by sea level fluctuations, influenced by atmospheric and astronomical forces, which motivates synoptic and climatological analysis, including meteorological and astronomical tidal phenomena. This study aimed to assess the evolution of tidal components and the relative mean sea level (MSL) between 1990 and 2021, as well as the atmospheric influence on extreme meteorological tide events, in which the MSL exceeded ±2 and ±3 (±29.98 and ±44.97 cm) standard deviations. The results have shown that, albeit small, the main tidal components (, , , , , , and ) indicated positive trends in the increase of amplitude and phase, despite the small quantities. For the relative MSL, an increase of 0.30 cm·year−1 was observed in agreement with estimates from global series from satellite altimeters and climate model predictions. Pressure and wind field analyses led to the identification of seasonal variability and the pattern of evolution of atmospheric systems associated with extreme events. In the case of positive surges, very intense winds from the SW, extending along the S/SE Brazilian coast, are caused by the presence of a high‐pressure centre over the continent and low‐pressure centres over the ocean, leading to water piling up. In turn, negative surges are caused by the presence of an anticyclone over the ocean, generating NE winds parallel to the coast of Rio de Janeiro, inducing Ekman transport and lowering the sea level. Therefore, the extreme sea level events in the Guanabara Bay are not triggered by local forces, but rather depend on the temporal persistence and direction of winds along the S/SE Brazilian coast.
Obvious difference of dominant circulation patterns between dry‐type and humid‐type heatwaves in North China
Authors: Ding Ting , Gao Hui , Xie Tiejun 
Published: August 2024

AbstractBased on the observed maximum temperature (Tmax), relative humidity (RH) and NCEP/NCAR reanalysis data during 1981–2021, basic temporal features and dominant atmospheric circulation patterns of dry‐type and humid‐type heatwaves in North China are investigated and compared. Statistical results indicate the dry heatwaves occur mainly in early summer (from early June to early July), that is, before the rainy season of North China, while the humid heatwaves have a high frequency in mid‐July to mid‐August. During the research period, the increasing trend of dry heatwaves is 0.67 days·decade−1, while the humid heatwaves increase at a greatly higher rate of 1.85 days·decade−1. For the dry heatwave, a high ridge in the subtropical westerlies plays the main role, and the northerly wind in the east of the ridge reduces the air moisture convergence over the region. However, for the humid heatwave, the westward and northward propagations of the western Pacific subtropical high (WPSH) may make the major contribution, and the southerly wind anomalies in the west of the WPSH enlarge the water vapour to the region. The adiabatic heating in subsiding air at all levels and horizontal temperature advection at lower troposphere are stronger for dry heatwaves than for humid heatwaves, which cause a higher Tmax for the former type. These results highlight the diversity of the heatwaves in North China, which suggests that multiple local and large‐scale subseasonal circulations should be considered to improve the subseasonal to seasonal forecast skills for heat extremes.
Heatwaves in Vietnam: Characteristics and relationship with large‐scale climate drivers
Authors: Pham‐Thanh Ha , Pham‐Thi Ly , Phan Hien , Fink Andreas H. , van der Linden Roderick , Phan‐Van Tan 
Published: August 2024

AbstractThis study analyses the spatio‐temporal variability of heatwave characteristics and their association with large‐scale climate drivers across seven climatic sub‐regions in Vietnam, including the Northwest (R1), Northeast (R2), Red River Delta (R3), North Central (R4), South Central (R5), Central Highlands (R6) and the South (R7). The analysis is based on observed daily maximum temperatures from 102 meteorological stations, spanning the period 1980–2020. The obtained results reveal diverse heatwave patterns across the country. Amongst the seven climatic sub‐regions of Vietnam, the R3 and R4 sub‐regions experienced more frequent heatwaves and a higher number of heatwave days, but shorter durations. In contrast, other sub‐regions had fewer heatwave events and heatwave days but experienced longer‐lasting heatwaves. The intensity of heatwave events varies amongst sub‐regions, with the highest value in the R4 sub‐region, and the lowest in R7. Notably, the R1–R5 sub‐regions are affected by heatwaves over larger areas, compared to others. Additionally, the findings confirm that the lagged influence of El Niño–Southern Oscillation (ENSO) is the primary climatic driver of heatwave characteristics in Vietnam. Generally, heatwaves tend to occur more frequently in the years following El Niño events than after La Niña events. This observation provides opportunities for developing a system of seasonal predictions of heatwaves in Vietnam. The impact of ENSO on the number of heatwave events and heatwave days is evident in five out of seven sub‐regions, with less impact in the R2 and R7 sub‐regions. However, it does not significantly affect heatwave intensity.
Effect of hot‐air drying on drying characteristics and quality of tiger nut
Authors: Chen Pengxiao , Bao Han , Jiang Mengmeng , Zhu Wenxue , Zhao Yating , Zhang Runyang , Zhu Kaihao 
Published: August 2024

AbstractBACKGROUNDThe delayed drying of newly harvested tiger nuts can lead to mold and rancidity. Timely drying is therefore important. However, few studies have analyzed the impact of hot‐air drying on the quality of tiger‐nut oil and starch, making it essential to establish optimal drying conditions.RESULTSThe results showed that the drying temperature was the most important factor affecting the drying speed, followed by drying airflow rate and loading capacity. A logarithmic model can describe the hot‐air drying process of tiger nuts. The oil yield of tiger nut was highest after drying at 60 °C, reaching 22.40%. Meanwhile, the starch extracted from after drying at 60 °C had the highest solubility and expansion rate, 4.77% and 9.74%, respectively. Starch has the highest viscosity after drying at 70 °C, and it forms gel easily after aging.CONCLUSIONHigh‐quality tiger nuts should be produced under optimal conditions: a hot‐air drying temperature of 60 °C, an airflow rate of 1.0 m s−1, and a loading capacity of 100 g. The results of this study have practical implications for the effective drying of tiger nuts. © 2024 Society of Chemical Industry.
Drug sensitivity tumor cell clusters in malignant peritoneal mesothelioma
Authors: Su Yan‐Dong , Ma Ru , Fu Yu‐Bin , Wu He‐Liang , Liang Xin‐Li , Liu Yi‐Tong , Yu Yang , Yang Zhi‐Ran , Li Yan 
Published: August 2024

AbstractBackgroundTo explore the most effective adjuvant chemotherapy regimen for malignant peritoneal mesothelioma (MPM) through patient derived tumor‐like cell clusters (PTC) drug sensitivity test.MethodsPTC were cultured in vitro with intraoperative specimens, and drug sensitivity test was performed to calculate the most effective chemotherapy regimen for MPM. The patients were divided into conventional and individualized chemotherapy group according to whether they received PTC drug testing. Univariate and multivariate analyses were conducted to identify independent prognostic factors.ResultsAmong 186 MPM patients included, 63 underwent PTC culture and drug sensitivity test. The results showed that the most effective chemotherapy regimen was oxaliplatin + gemcitabine. After propensity score matching, a total of 64 patients were enrolled in the following study, including 32 patients receiving individualized chemotherapy guided by PTC drug results as group 1 and 32 patients receiving conventional chemotherapy as group 2. Survival analysis showed that the median OS of group 1 was not reached, significantly longer than that of group 2 (23.5 months) (p < 0.05).ConclusionsCompared with conventional chemotherapy, individualized chemotherapy guided by PTC drug sensitivity tests can prolong patient survival, and oxaliplatin + gemcitabine + apatinib could be the optimal adjuvant treatment regimen for MPM.
The influence of fence design on the movement patterns of eastern long‐necked turtles
Authors: Dowling James M. , Bower Deborah S. , Boscarino‐Gaetano Remo , Nordberg Eric J. 
Published: August 2024

AbstractFences disturb the movements of terrestrial species, altering migration patterns, limiting access to vital resources, and reducing genetic diversity. With almost 40% of the Earth's land surface converted for agriculture, farm fencing to protect crops and corral livestock is expected to stretch into the millions of kilometers. As semi‐terrestrial ectotherms, freshwater turtles are threatened by fences that limit access to resources and increase risks of desiccation, entanglement, and overheating, often resulting in death. To determine the effect of fences, we quantified the movement patterns for a population of eastern long‐necked turtles (Chelodina longicollis) inhabiting an agricultural landscape near Armidale, New South Wales, Australia from November 2022 to September 2023. There was considerable variation in the distance traveled, home range size, and movement corridor selection between turtles that was not explained by the morphological factors of size, mass, or the loss of a limb (likely due to predation attempts). On average, 38% ± 4.70 ( ± SE) of turtle movements were terrestrial (overland) during their active season (spring and summer) during which they encountered fences frequently because of a complex matrix of paddocks. Fence design dictated the distance turtles traveled to locate a suitable passage point. The majority of fences allowed turtles to pass (turtle‐friendly fences, 71.4% of total fence distance) as opposed to turtle‐unfriendly fences (28.6% of total fence distance). Turtles were required to travel almost 4 times the distance to locate a suitable crossing point (a gap or fault in the fence) when they encountered an unfriendly fence (85.32 m ± 29.81) compared to a turtle‐friendly fence (25.85 m ± 3.58). Our results highlight the need for land managers to avoid small‐diameter exclusion fencing and fence designs containing chicken wire that extend to or below ground level. In settings where small‐diameter wire fencing is required, we recommend the installation of turtle gates for small terrestrial fauna or elevating bottom wires at least 50 mm above ground level to facilitate fence permeability.
A Sixteen‐user Time‐bin Entangled Quantum Communication Network With Fully Connected Topology
Authors: Huang Yiwen , Qi Zhantong , Yang Yilin , Zhang Yuting , Li Yuanhua , Zheng Yuanlin , Chen Xianfeng 
Published: August 2024

AbstractQuantum key distribution (QKD) promises unconditionally information‐theoretic secure communication guaranteed by the laws of physics and has become one of the most crucial candidates in future security aspects. Developing a large‐scale network with a scalable and integrated scheme is of great significance for expanding the advantages of QKD protocols among multiple users. Here, a sixteen‐user fully connected quantum network by using a novel time‐bin entangled source implemented in the integrated multi‐channel periodically poled lithium niobate waveguides is proposed. Based on this entangled source, the quantum processor prepares 120 entangled photon pairs to allocate 15 links to each user by utilizing dense wavelength division multiplexing technology. To enable the users’ communication with each other simultaneously, a phase‐compensated Mach‐Zehnder Interferometer based on a Fourier‐transform setup to control the relative phase of the interferometer for all the involved wavelength channels is developed. The experimental results show that the network can support sixteen users for long‐distance communication with each other simultaneously. The novel scheme of time‐bin entangled sources paves an efficient way for implementing large‐scale quantum resources in a compact integrated platform, and the time‐bin entangled network promises a new potential for constructing large‐scale and extensible quantum networks with an integrated photonic architecture.
Eco‐Friendly, Recyclable Supramolecular Inks Incorporating Multi‐Walled Carbon Nanotubes
Authors: Ding Chunxiao , Bai Meng , Liu Ruirui , Zhang Xinyue , Ma Ning , Abd‐El‐Aziz Alaa S. 
Published: August 2024

AbstractIn contemporary society, with its emphasis on environmental stewardship, the development of “green” (eco‐friendly) inks is of paramount importance. These inks are utilized across a broad spectrum of applications, ranging from the printing of packaging material to the 3D printing of functional components. This study explores the synthesis of eco‐friendly, biodegradable supramolecular polymer materials predicated on ureido‐pyrimidinone (UPy). The subsequent formulation of these materials into functional inks is achieved by the incorporation of multi‐walled carbon nanotubes (MWCNTs). These resultant inks exhibit outstanding photothermal conversion properties, robust electrical conductivity, intrinsic self‐repair capabilities, and superior writability. Moreover, this research demonstrates the recyclability of MWCNTs within the ink matrix, exhibiting a recovery efficiency of ≈90%. Such a high recovery rate offers a novel perspective on the sustainable reuse of conductive fillers in polymer‐based inks.
Measure theoretic aspects of the finite Hilbert transform
Authors: Curbera Guillermo P. , Okada Susumu , Ricker Werner J. 
Published: August 2024

AbstractThe finite Hilbert transform , when acting in the classical Zygmund space (over ), was intensively studied in [8]. In this note, an integral representation of is established via the ‐valued measure for each Borel set . This integral representation, together with various non‐trivial properties of , allows the use of measure theoretic methods (not available in [8]) to establish new properties of . For instance, as an operator between Banach function spaces is not order bounded, it is not completely continuous and neither is it weakly compact. An appropriate Parseval formula for plays a crucial role.
Controllable Design and Synthesis of Polyurethane Elastomers Containing Polar Dangling Chains with High Mechanical Properties and Wide Damping Temperature Range
Authors: Zhang Zhenpeng , Li Lin , Jiang Xiaolin , Lu Xun 
Published: August 2024

AbstractVibration and noise severely affect the operation of mechanical equipment and is also detrimental to human health. Therefore, the development of high performance damping materials is crucial. However, current methods to improve damping properties often come at the expense of mechanical properties, resulting in inferior mechanical performance of materials. In order to address the issue of imbalance between damping properties and mechanical properties in polyurethane damping elastomers. In this study, polyester dangling chains containing polar groups are synthesized and introduced into polyurethane. The obtained polyurethane exhibited an effective damping temperature range of 154 °C (−54 °C to 100 °C) and a tensile strength of 15.82 MPa. Furthermore, dynamic mechanical analysis and broadband dielectric relaxation spectroscopy are combined to investigate the influence of polar dangling chains on the structure and properties of polyurethane. The degree of microphase separation increases after the introduction of polar dangling chains, indicating enhances intermolecular interaction forces, facilitating the formation of hydrogen bond between the main chain and dangling chains, thereby increasing molecular chain friction and energy dissipation. This work overcomes the challenge of balancing the damping and mechanical properties of polyurethane, providing a new strategy for designing high performance polyurethane damping elastomers.
An inflammatory liquid fingerprint predicting tumor recurrence after liver transplantation for hepatocellular carcinoma
Authors: Yang Modan , Lin Zuyuan , Zhuang Li , Pan Linhui , Wang Rui , Chen Hao , Hu Zhihang , Shen Wei , Zhuo Jianyong , Yang Xinyu , Li Huigang , He Chiyu , Yang Zhe , Xie Qinfen , Dong Siyi , Chen Junli , Su Renyi , Wei Xuyong , Yin Junjie , Zheng Shusen , Lu Di , Xu Xiao 
Published: August 2024

AbstractTumor recurrence is a life‐threatening complication after liver transplantation (LT) for hepatocellular carcinoma (HCC). Precise recurrence risk stratification before transplantation is essential for the management of recipients. Here, we aimed to establish an inflammation‐related prediction model for posttransplant HCC recurrence based on pretransplant peripheral cytokine profiling. Two hundred and ninety‐three patients who underwent LT in two independent medical centers were enrolled, and their pretransplant plasma samples were sent for cytokine profiling. We identified four independent risk factors, including alpha‐fetoprotein, systemic immune‐inflammation index, interleukin 6, and osteocalcin in the training cohort (n = 190) by COX regression analysis. A prediction model named inflammatory fingerprint (IFP) was established based on the above factors. The IFP effectively predicted posttransplant recurrence (area under the receiver operating characteristic curve [AUROC]: 0.792, C‐index: 0.736). The high IFP group recipients had significantly worse 3‐year recurrence‐free survival rates (37.9 vs. 86.9%, p < 0.001). Simultaneous T‐cell profiling revealed that recipients with high IFP were characterized by impaired T cell function. The IFP also performed well in the validation cohort (n = 103, AUROC: 0.807, C‐index: 0.681). In conclusion, the IFP efficiently predicted posttransplant HCC recurrence and helped to refine pretransplant risk stratification. Impaired T cell function might be the intrinsic mechanism for the high recurrence risk of recipients in the high IFP group.
Endoplasmic reticulum stress in diseases
Authors: Liu Yingying , Xu Chunling , Gu Renjun , Han Ruiqin , Li Ziyun , Xu Xianrong 
Published: August 2024

AbstractThe endoplasmic reticulum (ER) is a key organelle in eukaryotic cells, responsible for a wide range of vital functions, including the modification, folding, and trafficking of proteins, as well as the biosynthesis of lipids and the maintenance of intracellular calcium homeostasis. A variety of factors can disrupt the function of the ER, leading to the aggregation of unfolded and misfolded proteins within its confines and the induction of ER stress. A conserved cascade of signaling events known as the unfolded protein response (UPR) has evolved to relieve the burden within the ER and restore ER homeostasis. However, these processes can culminate in cell death while ER stress is sustained over an extended period and at elevated levels. This review summarizes the potential role of ER stress and the UPR in determining cell fate and function in various diseases, including cardiovascular diseases, neurodegenerative diseases, metabolic diseases, autoimmune diseases, fibrotic diseases, viral infections, and cancer. It also puts forward that the manipulation of this intricate signaling pathway may represent a novel target for drug discovery and innovative therapeutic strategies in the context of human diseases.