bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unravelling the genomic and environmental diversity of the ubiquitous Solirubrobacter
Authors: Jara‐Servin Angélica , Mejia Gerardo , Romero Miguel F. , Peimbert Mariana , Alcaraz Luis David 
Published: August 2024

AbstractSolirubrobacter, though widespread in soils and rhizospheres, has been relatively unexplored despite its ubiquity. Previously acknowledged as a common soil bacterium, our research explores its phylogenomics, pangenomics, environmental diversity, and interactions within bacterial communities. By analysing seven genomic sequences, we have identified a pangenome consisting of 19,645 protein families, of which 2644 are shared across all studied genomes, forming the core genome. Interestingly, despite the non‐motility of reported isolates, we discovered genes for flagellin and a partial flagellum assembly pathway. Examining the 16S ribosomal RNA genes of Solirubrobacter revealed substantial diversity, with 3166 operational taxonomic units identified in Mexican soils. Co‐occurrence network analysis further demonstrated its significant integration within bacterial communities. Through phylogenomic scrutiny, we conclusively excluded the NCBI's GCA_009993245.1 genome from being classified as a Solirubrobacter. Our research into the metagenomic diversity of Solirubrobacter across various environments confirmed its presence in rhizospheres and certain soils, underscoring its adaptability. The geographical ubiquity of Solirubrobacter in rhizospheres raises intriguing questions regarding its potential interactions with plant hosts and the biotic and abiotic factors influencing its presence in soil. Given its ecological significance and genetic diversity, Solirubrobacter warrants further investigation as a potentially crucial yet underappreciated keystone species.
The Changing Face of Allotments: Findings from a Comprehensive Birmingham Study
Authors: Bloomfield Jon , Draycott David 
Published: August 2024

AbstractInterest in allotments is growing across the country, yet relatively little is known about them. Who are the current plot‐holders; what do they grow and the volumes of crops harvested; what are the wider health and social benefits gained from being a plot‐holder; how are allotments responding to an era of local government austerity?To explore these issues, we undertook a survey of allotment tenants and site secretaries across Birmingham's 113 sites in the most substantial study of plot‐holders undertaken in recent years. This article highlights the key findings and the potential implications for policy makers, local councillors and national politicians. It also indicates the need for similar studies elsewhere in the country to confirm or modify the picture suggested from this initial study.
Do Celebrities Make Policy?
Authors: Street John 
Published: August 2024

AbstractDo celebrities exercise power over policy making? It can seem that they do, at least in the way the media reports their political activities. We need to think only of the coverage of the footballer Marcus Rashford's seemingly successful campaign to get the Johnson administration to change its policy on free school meals. But are such accounts to be trusted? This is a question whose answer has implications for how we understand and judge contemporary democracy. Celebrities, after all, are unelected and unaccountable. This article asks, therefore, whether it is plausible to claim that stars of popular culture are to be counted amongst the politically powerful.
The effectiveness of the Mediterranean Diet for primary and secondary prevention of cardiovascular disease: An umbrella review
Authors: Hareer Laima W. , Lau Yan Ying , Mole Frances , Reidlinger Dianne P. , O'Neill Hayley M. , Mayr Hannah L. , Greenwood Hannah , Albarqouni Loai 
Published: August 2024

AbstractAimsThis study aimed to review meta‐analyses of randomised controlled trials that evaluated the effectiveness of the Mediterranean Diet for the primary and secondary prevention of cardiovascular disease.MethodsFive databases (Medline, Embase, Cochrane, CINAHL and ProQuest) were searched from inception to November 2022. Inclusion criteria were: (i) systematic review of randomised controlled studies with metanalysis; (ii) adults ≥18 years from the general population with (secondary prevention) and without (primary prevention) established cardiovascular disease; (iii) Mediterranean Diet compared with another dietary intervention or usual care. Review selection and quality assessment using AMSTAR‐2 were completed in duplicate. GRADE was extracted from each review, and results were synthesised narratively.ResultsEighteen meta‐analyses of 238 randomised controlled trials were included, with an 8% overlap of primary studies. Compared to usual care, the Mediterranean Diet was associated with reduced cardiovascular disease mortality (n = 4 reviews, GRADE low certainty; risk ratio range: 0.35 [95% confidence interval: 0.15–0.82] to 0.90 [95% confidence interval: 0.72–1.11]). Non‐fatal myocardial infarctions were reduced (n = 4 reviews, risk ratio range: 0.47 [95% confidence interval: 0.28–0.79] to 0.60 [95% confidence interval: 0.44–0.82]) when compared with another active intervention. The methodological quality of most reviews (n = 16/18; 84%) was low or critically low and strength of evidence was generally weak.ConclusionsThis review showed that the Mediterranean Diet can reduce fatal cardiovascular disease outcome risk by 10%–67% and non‐fatal cardiovascular disease outcome risk by 21%–70%. This preventive effect was more significant in studies that included populations with established cardiovascular disease. Better quality reviews are needed.
Seven new Rhopalomyia gall midges (Diptera: Cecidomyiidae) from Australia broaden the scope of the genus
Authors: Adair Robin J. , Kolesik Peter , Bronstein Omri , Dorchin Netta 
Published: August 2024

AbstractSeven new species of Rhopalomyia Rübsaamen, 1892 are described from eastern Australia feeding on a diverse range of plant genera and families. All induce galls on flower or growth buds: Rhopalomyia cassiniae Adair & Kolesik, sp. nov. on Cassinia subtropica (Asteraceae), Rhopalomyia digitata Adair & Kolesik, sp. nov. on Podolobium ilicifolium (Fabaceae), Rhopalomyia glebosa Adair & Kolesik, sp. nov. on Parsonsia straminea (Apocynaceae), Rhopalomyia inconspicua Adair & Kolesik, sp. nov. on Kunzea sp. (Myrtaceae), Rhopalomyia ozothamniae Adair & Kolesik, sp. nov. on Ozothamnus ferrugineus (Asteraceae), Rhopalomyia pultenicola Adair & Kolesik, sp. nov. on Pultenaea forsythiana (Fabaceae) and Rhopalomyia stypheliae Adair & Kolesik, sp. nov. on Syphelia triflora (Ericaceae). The scope of Rhopalomyia is broadened to contain species with a partially setulose gonostyle and a four‐segmented palp, a decision supported by a phylogenetic analysis based on the barcoding section of the mitochondrial COI gene. Apocynaceae, Ericaceae, Fabaceae and Myrtaceae are recorded as hosts of Rhopalomyia for the first time.
New insect family for Australia: Chrysostylops australiensis Benda & Straka, gen. et sp. nov. (Strepsiptera: Stylopidae) described from Chrysocolletes aureus Leijs & Hogendoorn, 2021 (Hymenoptera: Colletidae)
Authors: Benda Daniel , Parslow Ben A. , Leijs Remko , Straka Jakub 
Published: August 2024

AbstractA new genus and species of Strepsiptera, Chrysostylops australiensis Benda & Straka, gen. et sp. nov., is described. It represents the first record of the family Stylopidae from Australia. It was parasitising the bee species Chrysocolletes aureus Leijs & Hogendoorn, 2021 (Neopasiphaeinae). The diagnosis and description of the genus and species are provided based on the characters of the female cephalothorax. Diagnostic characters are discussed. The male and first instar larvae of C. australiensis are unknown. We removed Hylecthrini Ulrich, 1930 reinst. stat. from synonymy based on the specific sculpture on the female cephalothorax. The tribe is specialised for bees of the family Colletidae.
Subjective sleep may mediate the associations between tomorrow anticipations and next‐day affect
Authors: Lee Soomi 
Published: August 2024

AbstractThis study investigated whether stress and positive anticipations about tomorrow are associated with emotional experiences the following day, mediated by the preceding night's sleep. Data were from 141 full‐time nurses, utilizing a 14‐day ecological momentary assessment combined with actigraphy sleep monitoring. Each evening, participants rated the anticipated pleasantness or stressfulness of the following day. Each morning, participants reported on their previous night's sleep. Additionally, participants reported their momentary positive affect (PA) and negative affect (NA) three times per day, with daily averages computed. Multilevel mediation models, adjusted for sociodemographics, work shift, workday, and previous day's affect, revealed that days following more stress anticipations were associated with reduced PA and increased NA. Conversely, days following more pleasantness anticipations were associated with increased PA and decreased NA. These within‐person associations were mediated by self‐reported time‐in‐bed, sufficiency, and quality, such that less stressful and more pleasant anticipations were associated with better sleep, and better sleep was subsequently associated with increased PA and decreased NA. No mediation was found by the actigraphy sleep parameters. Findings suggest that emotional states may covary not only with present stimuli but also with anticipation of future events and subjective sleep recovery in the context of those anticipations.
Applying current European periodontitis clinical practice guidelines is not feasible even for the richest countries in the world
Authors: Raittio Eero , Grytten Jostein , Lopez Rodrigo , Blich Carl Christian , Vettore Mario Vianna , Baelum Vibeke 
Published: August 2024

AbstractClinical practice guidelines aim to enhance the quality, equality and consistency of care but often demand more time than is available, rendering adherence impractical and exceeding feasible resources. The 2017 introduction of a new periodontal classification system by the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) sought to refine clinical and epidemiological practices by serving as the basis for clinical practice guidelines and epidemiological investigations around the world. Following this classification, the EFP recommends supportive periodontal care visits every 3–12 months for all periodontitis cases. Given that in Norway, approximately 72% of the adult population are identified as periodontitis cases under the current AAP/EFP case definition, this poses a significant demand on healthcare resources. We calculated that between 60% and 70% of all estimated available working hours available for adult dental care provided by dentists and dental hygienists in Norway in 2017 would be spent on supportive periodontal care visits alone if the recommendations were to be met. This situation calls for a reevaluation of disease definitions and clinical practice guidelines to ensure they are practical, financially feasible and patient‐outcome relevant.
Unveiling the shield: Troglitazone's impact on epilepsy‐induced nerve injury through ferroptosis inhibition
Authors: Wang Zhi‐Bin , Liu Jun‐Yan , Jiang Shi‐Long , Zhuo Wei , Xie Pan , Dai Wen‐Ting , Mao Xiao‐Yuan , Liu Zhao‐Qian 
Published: August 2024

AbstractBackgroundEpilepsy is a widespread central nervous system disorder with an estimated 50 million people affected globally. It is characterized by a bimodal incidence peak among infants and the elderly and is influenced by a variety of risk factors, including a significant genetic component. Despite the use of anti‐epileptic drugs (AEDs), drug‐refractory epilepsy develops in about one‐third of patients, highlighting the need for alternative therapeutic approaches.AimsThe primary aim of this study was to evaluate the neuroprotective effects of troglitazone (TGZ) in epilepsy and to explore the potential mechanisms underlying its action.MethodsWe employed both in vitro and in vivo models to assess TGZ's effects. The in vitro model involved glutamate‐induced toxicity in HT22 mouse hippocampal neurons, while the in vivo model used kainic acid (KA) to induce epilepsy in mice. A range of methods, including Hoechst/PI staining, CCK‐8 assay, flow cytometry, RT‐PCR analysis, Nissl staining, scanning electron microscopy, and RNA sequencing, were utilized to assess various parameters such as cellular damage, viability, lipid‐ROS levels, mitochondrial membrane potential, mRNA expression, seizure grade, and mitochondrial morphology.ResultsOur results indicate that TGZ, at doses of 5 or 20 mg/kg/day, significantly reduces KA‐induced seizures and neuronal damage in mice by inhibiting the process of ferroptosis. Furthermore, TGZ was found to prevent changes in mitochondrial morphology. In the glutamate‐induced HT22 cell damage model, 2.5 μM TGZ effectively suppressed neuronal ferroptosis, as shown by a reduction in lipid‐ROS accumulation, a decrease in mitochondrial membrane potential, and an increase in PTGS2 expression. The anti‐ferroptotic effect of TGZ was confirmed in an erastin‐induced HT22 cell damage model as well. Additionally, TGZ reversed the upregulation of Plaur expression in HT22 cells treated with glutamate or erastin. The downregulation of Plaur expression was found to alleviate seizures and reduce neuronal damage in the mouse hippocampus.ConclusionThis study demonstrates that troglitazone has significant therapeutic potential in the treatment of epilepsy by reducing epileptic seizures and the associated brain damage through the inhibition of neuronal ferroptosis. The downregulation of Plaur expression plays a crucial role in TGZ's anti‐ferroptotic effect, offering a promising avenue for the development of new epilepsy treatments.
Comparative Analysis of Fistula Development After Parotid Gland Surgery: Lateral Parotidectomy Versus Extracapsular Dissection Technique
Authors: Sadok Nadia , Bastian Tobias , Voss Noemi , Stähr Kerstin , Arweiler‐Harbeck Diana , Lang Stephan , Meyer Moritz 
Published: August 2024

ABSTRACTPurposeThe primary objective of this study was to explore the potential disparity in postoperative fistula occurrence rates between patients who undergo (partial) lateral parotidectomy and those who undergo the extracapsular dissection technique for the management of benign parotid gland tumours.MethodsA consecutive series of 363 patients treated with (partial) lateral parotidectomy and extracapsular dissection technique for benign parotid gland tumours at one tertiary centre between 2018 and 2022 were included. To evaluate the impact of the surgical technique and possible other risk factors (tumour location, tumour size, Body Mass Index, age, smoking, diabetes mellitus, arterial hypertension) for the development of fistulas, multivariate logistic regression analyses using backward lection were applied to estimate odds ratios (ORs) and 95%‐confidence intervals (CIs).ResultsIn 363 patients, 21 patients (5.8%) developed a fistula. Patients who underwent (partial) lateral parotidectomy had three times higher chance of developing a fistula compared to patients who were operated using the extracapsular dissection technique (ORadjusted = 2.6, 4.1% vs. 12.5%, p = 0.044). In the multivariate analyses, no other risk factors for the development of fistulas were statistically significant in this cohort. The incidence of facial nerve paralysis was not significantly different between the extracapsular dissection and lateral parotidectomy group (5/73 = 6.8% vs. 11/290 = 3.8%, p = 0.333).ConclusionFistulas occur more often in patients treated by means of a (partial) lateral parotidectomy approach compared to patients treated using the extracapsular dissection technique. Therefore, surgeons should be vigilant about postoperative fistula risks in lateral parotidectomy and consider preventive measures.
The Deubiquitinase USP22‐Stabilized COL17A1 Promotes Lung Adenocarcinoma Progression
Authors: Chen Guangxi , Du Dandan , Wang Haihua , Li Huifeng 
Published: August 2024

ABSTRACTBackgroundLung adenocarcinoma (LUAD) is a highly aggressive and rapidly fatal malignancy worldwide. Collagen XVII (COL17A1) has been implicated in various protumorigenic processes. However, the functions and mechanisms of COL17A1 in LUAD progression still remain elusive.MethodsCOL17A1 and ubiquitin‐specific protease 22 (USP22) mRNA analysis was performed by quantitative PCR, and their protein levels were detected by immunoblotting and immunohistochemistry. The functional influence was evaluated by determining cell viability, proliferation, apoptosis, invasion, migration, and ferroptosis in vitro, as well as xenograft growth in vivo. Co‐immunoprecipitation (Co‐IP) and IP experiments were used to examine the USP22/COL17A1 interaction and COL17A1 deubiquitination. Cycloheximide treatment was used to analyze COL17A1 protein stability.ResultsCOL17A1 and USP22 were upregulated in human LUAD tissues and cell lines. Functionally, COL17A1 knockdown acted for the suppression of LUAD cell growth, invasion, and migration as well as promotion of cell apoptosis and ferroptosis in vitro. COL17A1 knockdown could diminish the tumorigenicity of LUAD cells in vivo. Mechanistically, USP22 stabilized and upregulated COL17A1 by enhancing the deubiquitination of COL17A1. Additionally, reexpression of COL17A1 could reverse USP22 silencing‐induced phenotype changes of LUAD cells in vitro.ConclusionOur findings demonstrate that USP22‐stabilized COL17A1 possesses oncogenic activity in LUAD. We propose that USP22 and COL17A1 would be potential targets for the establishment of therapeutic approaches against LUAD.
Clinical evidence for high‐risk CE‐marked medical devices for glucose management: A systematic review and meta‐analysis
Authors: Bano Arjola , Künzler Juri , Wehrli Faina , Kastrati Lum , Rivero Tania , Llane Adea , Valz Gris Angelica , Fraser Alan G. , Stettler Christoph , Hovorka Roman , Laimer Markus , Bally Lia ,   CORE‐MD investigators
Published: August 2024

AbstractAimsTo conduct a systematic review and meta‐analysis, within the Coordinating Research and Evidence for Medical Devices (CORE‐MD) project, evaluating CE‐marked high‐risk devices for glucose management.Materials and MethodsWe identified interventional and observational studies evaluating the efficacy and safety of eight automated insulin delivery (AID) systems, two implantable insulin pumps, and three implantable continuous glucose monitoring (CGM) devices. We meta‐analysed randomized controlled trials (RCTs) comparing AID systems with other treatments.ResultsA total of 182 studies published between 2009 and 2024 were included, comprising 166 studies on AID systems, six on insulin pumps, and 10 on CGM devices; 26% reported industry funding; 18% were pre‐market; 37% had a comparator group. Of the studies identified, 29% were RCTs, 24% were non‐randomized trials, and 47% were observational studies. The median (interquartile range) sample size was 48 (28–102), age 34.8 (14–44.2) years, and study duration 17.5 (12–26) weeks. AID systems lowered glycated haemoglobin by 0.5 percentage points (absolute mean difference [MD] = −0.5; 21 RCTs; I2 = 86%) and increased time in target range for sensor glucose level by 13.4 percentage points (MD = 13.4; 14 RCTs; I2 = 90%). At least one safety outcome was assessed in 71% of studies.ConclusionsHigh‐risk devices for glucose monitoring or insulin dosing, in particular AID systems, improve glucose control safely, but evidence on diabetes‐related end‐organ damage is lacking due to short study durations. Methodological heterogeneity highlights the need for developing standards for future pre‐ and post‐market investigations of diabetes‐specific high‐risk medical devices.
Outcomes of older adults undergoing allogeneic hematopoietic cell transplantation with post‐transplant cyclophosphamide based prophylaxis
Authors: Murillo Victoria , Charry Paola , Suárez‐Lledó María , Guardia Laia , Moreno Cristina , Cid Joan , Lozano Miquel , Pedraza Alexandra , Salinas Raquel , Vilas Vanessa , Duch Montserrat , Díaz‐Beya Marina , Rosiñol Laura , Esteve Jordi , Carreras Enric , Fernández‐Avilés Francesc , Martínez Carmen , Rovira Montserrat , Salas María Queralt 
Published: August 2024

AbstractThis study evaluates the feasibility of using post‐transplant cyclophosphamide (PTCY) prophylaxis in allo‐hematopoietic cell transplantation (HCT) for adults aged 65 and older. PTCY is increasingly used to prevent graft‐versus‐host disease (GVHD) across all donor types, but concerns remain about potential risks, especially in older patients. Fifty‐seven adults aged 65 or older with hematological malignancies, undergoing their first allo‐HCT with PTCY prophylaxis between January 2011 and January 2023 were included. Overall, 94.8% of patients achieved primary engraftment. The median durations for neutrophil and platelet engraftments were 19 and 21 days. The day +30 cumulative incidence of bacterial bloodstream infection was 43.9%. No CMV reactivations occurred within the first 100 days after letermovir implementation. The day +180 cumulative incidences of grade II–IV and III–IV acute GVHD, and the 2‐year cumulative incidence of moderate/severe chronic GVHD were 26.3%, 10.5%, and 4.8%. Eighteen patients (31.6%) relapsed, and 30 (52.6%) died, with relapse (16.4%) and infection (11.5%) being the main causes of death. The estimated 2‐year overall survival, non‐relapse mortality, cumulative incidence of relapse, and GVHD‐free relapse‐free survival rates were 45.5%, 27.1%, 33.9%, and 37.0%. Adults aged 70 or older had similar outcomes to those aged 65–69. This study confirms the safety and feasibility of PTCY‐based allo‐HCT in older adults.
The value of talents
Authors: Sabah Nasim , Thompson Linh , Wei Zuobao 
Published: August 2024

AbstractWe exploit Employment Non‐Discrimination Acts, Paid Family Medical Leave Acts, and Lilly Ledbetter Fair Pay Act as quasi‐natural experiments to study the value of talents. Our findings suggest that firms with larger capacity to secure and maintain talent pipelines enjoy higher valuations. We further identify a channel through which talents increase firm value: innovation. The value of talents is more significant among high innovation intensity industries in which talents exhibit their value most evidently. Our findings also indicate that talents are costly to obtain and replace.