bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Multicomponent Synthesis of Highly Functionalized Piperidines Using Sulfamic Acid as a Heterogeneous and Cost Effective Catalyst.
Authors: Patil Dayanand , Chandam Dattatray , Mulik Abhijeet , Patil Prasad , Jagdale Suryabala , Deshmukh Madhukar 
Published: October 2015

AbstractThe reaction is restricted to aromatic amines and aldehydes.
ChemInform Abstract: Stereoselective Rearrangement of (Trifluoromethyl)prolinols to Enantioenriched 3‐Substituted 2‐(trifluoromethyl)piperidines.
Authors: Rioton Sarah , Orliac Aurelie , Antoun Zeina , Bidault Roselyne , Gomez Pardo Domingo , Cossy Janine 
Published: October 2015

AbstractThe straightforward regio‐ and diastereoselective title reaction allows for the synthesis of a broad range of 3‐substituted 2‐(trifluoromethyl)piperidines which are formed via ring‐opening of a (trifluoromethyl)aziridinium intermediate by various electrophiles including iodine, secondary amines, aniline, alcohols and thiols, sodium phenolate and water as well as C‐anions such as cyanide.
ChemInform Abstract: Regioselective Pd‐Catalyzed Synthesis of 2,3,6‐Trisubstituted Pyridines from Isoxazolinones.
Authors: Rieckhoff Stefan , Hellmuth Tina , Peters Rene 
Published: October 2015

AbstractPd(II)‐catalyzed C‐regioselective 1,4‐addition of isoxazolinones to vinyl ketones, followed by a Pd(0)‐catalyzed cyclization yields pyridines.
ChemInform Abstract: P2Et Phosphazene: A Mild, Functional Group Tolerant Base for Soluble, Room Temperature Pd‐Catalyzed C—N, C—O, and C—C Cross‐Coupling Reactions.
Authors: Buitrago Santanilla Alexander , Christensen Melodie , Campeau Louis‐Charles , Davies Ian W. , Dreher Spencer D. 
Published: October 2015

AbstractThe organic superbase P2‐Et is shown to possess distinct reactivity across a diverse set of cross‐coupling reactions at room temperature.
ChemInform Abstract: Enantioselective Synthesis of Functionalized 3,4‐Disubstituted Dihydro‐2(1H)‐quinolinones via Michael—Hemiaminalization/Oxidation Reaction.
Authors: Xia Ai‐Bao , Zhang Xiao‐Long , Wang Tao , Du Xiao‐Hua , Xu Dan‐Qian , Xu Zhen‐Yuan 
Published: October 2015

AbstractA concise synthesis of highly functionalized dihydroquinolinones with excellent diastereoselectivities and enantioselectivities by sequential organocatalytic Michael—hemiaminalization/oxidation reactions under mild reaction conditions is presented.
ChemInform Abstract: Synthesis of Indolizines Through Oxidative Linkage of C—C and C—N Bonds from 2‐Pyridylacetates.
Authors: Chandra Mohan Darapaneni , Ravi Chitrakar , Pappula Venkatanarayana , Adimurthy Subbarayappa 
Published: October 2015

AbstractAn Ortoleva—King reaction of pyridineacetate and ketones followed by intramolecular Aldol condensation under mild reaction conditions affords indolizine‐1‐carboxylates.
ChemInform Abstract: Direct One‐Pot Synthesis of Zolimidine Pharmaceutical Drug and Imidazo[1,2‐a]pyridine Derivatives via I2/CuO‐Promoted Tandem Strategy.
Authors: Cai Qun , Liu Mei‐Cai , Mao Bi‐Ming , Xie Xuan , Jia Feng‐Cheng , Zhu Yan‐Ping , Wu An‐Xin 
Published: October 2015

AbstractA new I2/CuO‐promoted one‐pot tandem strategy is presented for the synthesis of imidazo[1,2‐a]pyridine derivatives which has a broad scope of substrates, including aryl methyl ketones, heteroaryl ketones, α,β‐unsaturated methyl ketones, β‐ketone esters, and substituted 2‐aminopyridines.
ChemInform Abstract: Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones (DHPMs) by Natural L‐Ascorbic Acid.
Authors: Kodape Manisha M. , Gawhale Nandkishor D. , Awjare Nikita V. 
Published: October 2015

AbstractLemon juice contains ascorbic acid, which catalyzes the Biginelli synthesis of dihydropyrimidine derivatives.
ChemInform Abstract: Synthesis, Characterization and Antimicrobial Activity of Some New Baylis—Hillmann Derived Benzothiazolo Pyrimidinone Derivatives.
Authors: Gampa Raghavachary , Chebrolu Lavanya Devi , Jarapula Ravi , Vaidya Jayathirtha Rao , Ghanakota Venkateshwar Rao , Manda Sarangapani 
Published: October 2015

AbstractA series of 22 benzothiazolo pyrimidinones are prepared by cyclization of Baylis—Hillman acetates and aminobenzothiazole.
ChemInform Abstract: Carbon—Carbon Bond Cleavage Reaction: Synthesis of Multisubstituted Pyrazolo[1,5‐a]pyrimidines.
Authors: Saikia Pallabi , Gogoi Sanjib , Boruah Romesh C 
Published: October 2015

AbstractA base‐induced cyclization of 1,3,5‐triphenylpentane‐1,5‐diones and 3‐pyrazolamines affords 5,7‐diphenylpyrazolo[1,5‐a]pyrimidines in good yields via C—C bond cleavage.
ChemInform Abstract: Iodine Catalyzed Oxidative Synthesis of Quinazolin‐4(3H)‐ones and Pyrazolo[4,3‐d]pyrimidin‐7(6H)‐ones via Amination of sp3 C—H Bond.
Authors: Mohammed Shabber , Vishwakarma Ram A. , Bharate Sandip B. 
Published: October 2015

AbstractAn oxidative coupling of 2‐aminobenzamides with aryl methyl ketones using I2 as catalyst gives 2‐arylquinazolinones.
ChemInform Abstract: Iron‐Catalyzed Intramolecular C(sp2)—N Cyclization of 1‐(N‐Arylpyrrol‐2‐yl)ethanone O‐Acetyl Oximes Toward Pyrrolo[1,2‐a]quinoxaline Derivatives.
Authors: Zhang Zhiguo , Li Junlong , Zhang Guisheng , Ma Nana , Liu Qingfeng , Liu Tongxin 
Published: October 2015

AbstractSuccessive N—O bond cleavage and intramolecular directed C—H arylation of O‐acetyl(N‐arylpyrrole)acetoximes in AcOH yield pyrrolo[1,2‐a]quinoxalines.
ChemInform Abstract: Microwave‐Assisted Synthesis of Fused Piperazine‐Benzimidazoles via a Facile, One‐Pot Procedure.
Authors: Song Gui‐Ting , Li Shi‐Qiang , Yang Zhi‐Wei , Yuan Jian‐Hui , Wang Ming‐Shu , Zhu Jin , Chen Zhong‐Zhu , Xu Zhi‐Gang 
Published: October 2015

AbstractA convenient one‐pot protocol is developed for the synthesis of the title compounds (V) and (VII) through Ugi reaction/deprotection/cyclization strategy followed by an intramolecular nucleophilic substitution reaction.
ChemInform Abstract: Sulfamic Acid: An Efficient and Recyclable Solid Acid Catalyst for the Synthesis of 4,5‐Dihydropyrrolo[1,2‐a]quinoxalines.
Authors: Kamal Ahmed , Babu Korrapati Suresh , Hussaini S.M. Ali , Srikanth P. S. , Balakrishna Moku , Alarifi Abdullah 
Published: October 2015

AbstractSulfamic acid catalyzed reaction of substrate (I) with aldehydes provides the title compounds in excellent yields.
ChemInform Abstract: Heck—Suzuki Tandem Reaction for the Synthesis of 3‐Benzazepines.
Authors: Peshkov Anatoly A. , Peshkov Vsevolod A. , Pereshivko Olga P. , Van Hecke Kristof , Kumar Rakesh , V. Van der Eycken Erik 
Published: October 2015

AbstractThe microwave‐assisted title reaction between N‐protected 2‐(2‐bromoaryl)alkylpropargylamides and organo‐boron compounds gives the corresponding 3‐benzazepin‐2‐ones.
ChemInform Abstract: Cyclic α‐Alkoxyphosphonium Salts from (2‐(Diphenylphosphino)phenyl)methanol and Aldehydes and Their Application in Synthesis of Vinyl Ethers and Ketones via Wittig Olefination.
Authors: Huang Wenhua , Rong Hong‐Ying , Xu Jie 
Published: October 2015

AbstractThe obtained vinyl ethers can be easily converted into the corresponding ketones by heating in aq.
ChemInform Abstract: A Single‐Step One Pot Synthesis of Dialkyl Fluorophosphates from Dialkylphosphites.
Authors: Purohit Ajay Kumar , Pardasani Deepak , Kumar Ajeet , Goud D. Raghavender , Jain Rajiv , Dubey D. K. 
Published: October 2015

AbstractThe one‐pot chlorination of phosphites (I) and subsequent displacement of chloride by fluoride gives access to fluorophosphates (II) under mild conditions.
ChemInform Abstract: Novel Dammarane‐Type Triterpenes Isolated from Hydrolyzate of Total Gynostemma pentaphyllum Saponins.
Authors: Zhang Xiao‐Shu , Cao Jia‐Qing , Zhao Chen , Wang Xu‐de , Wu Xiao‐jun , Zhao Yu‐Qing 
Published: October 2015

AbstractIsolation and structure determination of five novel triterpenes, gypensapogenins H (Ia), I (Ib), L (II), J (III), and K (IV) are reported.
ChemInform Abstract: Cytotoxic Triterpene Saponins from Cercodemas anceps
Authors: Cuong Nguyen Xuan , Vien Le Thi , Hanh Tran Thi Hong , Thao Nguyen Phuong , Thao Do Thi , Thanh Nguyen Van , Nam Nguyen Hoai , Thung Do Cong , Kiem Phan Van , Minh Chau Van 
Published: October 2015

Abstractisolation and structure of five new holostane‐type triterpene saponins, cercodemasoides A—E (structures of cercodemasoides D (Ia) and E (Ib) are shown)
ChemInform Abstract: Two New Isopimarane Diterpenoids from the Endophytic Fungus Xylaria sp. SNB‐GTC2501.
Authors: Sorres Jonathan , Nirma Charlotte , Toure Seinde , Eparvier Veronique , Stien Didier 
Published: October 2015

AbstractThe novel diterpenoids xylabisboein A (I) and B (II) are isolated as well as three known secondary metabolites.
ChemInform Abstract: Cytotoxic Triterpenoids from Ficus pomifera Wall.
Authors: Wangkheirakpam Sujata D. , Wadawale Amey , Leishangthem Surendrajit S. , Gurumayum Jitendra S. , Laitonjam Warjeet S. 
Published: October 2015

AbstractTwo new triterpenoids, pomiferate (Ia) and 3β‐hydroxyurs‐12‐ene (Ib), are isolated together with three known compounds.
ChemInform Abstract: Efficient and Selective Azidation of per‐O‐Acetylated Sugars Using Ultrasound Activation: Application to the One‐Pot Synthesis of 1,2,3‐Triazole Glycosides.
Authors: Marzag Hamid , Alaoui Soukaina , Amdouni Hella , Martin Anthony R. , Bougrin Khalid , Benhida Rachid 
Published: October 2015

AbstractAn inexpensive, simple, and highly efficient process is developed for the selective anomeric azidation of protected sugars using ultrasound activation and an of iron catalyst.
ChemInform Abstract: Agelamadin F and Tauroacidin E, Bromopyrrole Alkaloids from an Okinawan Marine Sponge Agelas sp.
Authors: Kusama Taishi , Tanaka Naonobu , Kashiwada Yoshiki , Kobayashi Jun'ichi 
Published: October 2015

Abstractisolation and structure elucidation of agelamadin F (I) and tauroacidin E (II)
ChemInform Abstract: A Convenient Synthesis of Phebalosin: First Total Synthesis of Murraxocin.
Authors: Sen Indira , Sasmal Swarnendu , Ghorai Sujit K. , Pal Sitaram 
Published: October 2015

AbstractThe Corey—Chaykovsky reaction of aldehyde (I) and sulfonium salt (II) is the key step in the synthesis of phebalosin (III).
ChemInform Abstract: New PKS‐NRPS Tetramic Acids and Pyridinone from an Australian Marine‐Derived Fungus, Chaunopycnis sp.
Authors: Shang Zhuo , Li Li , Esposito Breno P. , Salim Angela A. , Khalil Zeinab G. , Quezada Michelle , Bernhardt Paul V. , Capon Robert J. 
Published: October 2015

AbstractTetramic acid F‐14329 (Ia), chaunolidines A‐C (Ib)—(III), chaunolidone A (IV), and pyridoxatin (V) are isolated from the title fungus.
ChemInform Abstract: Phosphonate Analogues of 1α, 25‐ Dihydroxyvitamin D3 Are Promising Candidates for Antitumoural Therapies
Authors: Salomon D. G. , Mascaro E. , Grioli S. M. , Ferronato M. J. , Vitale C. A. , Radivoy G. E. , Curino A. C. , Facchinetti M. M. 
Published: October 2015

AbstractReview: 162 refs.
ChemInform Abstract: Discovery of Novel Synthetic Methodologies and Reagents During Natural Product Synthesis in the Post‐Palytoxin Era
Authors: Armaly Ahlam M. , DePorre Yvonne C. , Groso Emilia J. , Riehl Paul S. , Schindler Corinna S. 
Published: October 2015

AbstractReview: 271 refs.
ChemInform Abstract: Pursuing Chemical Efficiency by Using Supported Organocatalysts for Asymmetric Reactions under Aqueous Conditions
Authors: Guillena Gabriela , Alonso Diego , Baeza Alejandro , Chinchilla Rafael , Flores‐Ferrandiz Jesus , Gomez‐Martinez Melania , Trillo Paz 
Published: October 2015

AbstractReview: 171 refs.
Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed
Authors: Van Liefferinge Joeri , Bentea Eduard , Demuyser Thomas , Albertini Giulia , Follin‐Arbelet Virginie , Holmseth Silvia , Merckx Ellen , Sato Hideyo , Aerts Joeri L. , Smolders Ilse , Arckens Lutgarde , Danbolt Niels C. , Massie Ann 
Published: October 2015

ABSTRACTThe cystine/glutamate antiporter or system
exchanges cystine for glutamate, thereby supporting intracellular glutathione synthesis and nonvesicular glutamate release. The role of system
in neurological disorders can be dual and remains a matter of debate. One important reason for the contradictory findings that have been reported to date is the use of nonspecific anti‐xCT (the specific subunit of system
) antibodies. Often studies rely on the predicted molecular weight of 55.5 kDa to identify xCT on Western blots. However, using brain extracts from xCT knockout (xCT−/−) mice as negative controls, we show that xCT migrates as a 35‐kDa protein. Misinterpretation of immunoblots leads to incorrect assessment of antibody specificity and thereby to erroneous data interpretation. Here we have verified the specificity of most commonly used commercial and some in‐house‐developed anti‐xCT antibodies by comparing their immunoreactivity in brain tissue of xCT+/+ and xCT−/− mice by Western blotting and immunohistochemistry. The Western blot screening results demonstrate that antibody specificity not only differs between batches produced by immunizing different rabbits with the same antigen but also between bleedings of the same rabbit. Moreover, distinct immunohistochemical protocols have been tested for all the anti‐xCT antibodies that were specific on Western blots in order to obtain a specific immunolabeling. Only one of our in‐house‐developed antibodies could reveal specific xCT labeling and exclusively on acetone‐postfixed cryosections. Using this approach, we observed xCT protein expression throughout the mouse forebrain, including cortex, striatum, hippocampus, midbrain, thalamus, and amygdala, with greatest expression in regions facing the cerebrospinal fluid and meninges. J. Comp. Neurol. 524:1015–1032, 2016. © 2015 Wiley Periodicals, Inc.
Realtime 31P NMR Investigation on the Catalytic Behavior of the Enzyme Adenylate kinase in the Matrix of a Switchable Ionic Liquid
Authors: Rogne Per , Sparrman Tobias , Anugwom Ikenna , Mikkola Jyri‐Pekka , Wolf‐Watz Magnus 
Published: October 2015

AbstractThe integration of highly efficient enzymatic catalysis with the solvation properties of ionic liquids for an environmentally friendly and efficient use of raw materials such as wood requires fundamental knowledge about the influence of relevant ionic liquids on enzymes. Switchable ionic liquids (SIL) are promising candidates for implementation of enzymatic treatments of raw materials. One industrially interesting SIL is constituted by monoethanol amine (MEA) and 1,8‐diazabicyclo‐[5.4.0]‐undec‐7‐ene (DBU) formed with sulfur dioxide (SO2) as the coupling media (DBU‐SO2‐MEASIL). It has the ability to solubilize the matrix of lignocellulosic biomass while leaving the cellulose backbone intact. Using a novel 31P NMR‐based real‐time assay we show that this SIL is compatible with enzymatic catalysis because a model enzyme, adenylate kinase, retains its activity in up to at least 25 wt % of DBU‐SO2‐MEASIL. Thus this SIL appears suitable for, for example, enzymatic degradation of hemicellulose.
Functional diversity of urban bird communities: effects of landscape composition, green space area and vegetation cover
Authors: Schütz Claudia , Schulze Christian H. 
Published: October 2015

AbstractIn this study, we aim to gain a better insight on how habitat filtering due to urbanization shapes bird communities of Vienna city parks. This may help to derive implications for urban planning in order to promote and maintain high diversity and ecosystem function in an increasing urbanized environment. The structure of wintering bird communities of 36 Vienna city parks – surveyed once a month in January 2009, December 2009, December 2012, and January 2013 – was described by species richness and the functional diversity measurements FRic (functional richness), FEve (functional evenness), and FDiv (functional divergence). Environmental filtering was quantified by park size, canopy heterogeneity within the park, and the proportion of sealed area surrounding each park. Species richness, FRic, and FDiv increased with increasing park size. Sealed area had a strong negative effect on species richness and FDiv. Canopy heterogeneity played a minor role in explaining variance in FDiv data. FEve did not respond to any of these park parameters. Our results suggest a loss of species richness and functional diversity, hence most likely indicate a decline in ecosystem function, with decreasing park size and increasing sealed area of the surrounding urban landscape matrix.
Lithium Polymer Electrolytes Based on Sulfonated Poly(ether ether ketone) for Lithium Polymer Batteries
Authors: Thayumanasundaram Savitha , Rangasamy Vijay Shankar , Seo Jin Won , Locquet Jean‐Pierre 
Published: October 2015

AbstractWe studied a lithium‐ion conducting polymer based on sulfonated poly(ether ether ketone) (SPEEK) doped with lithium bis(trifluoromethane)sulfonimide (LiTFSI). Self‐standing membranes were prepared by the solvent‐casting technique with a LiTFSI loading of 0 to 30 wt.‐%. The thermogravimetric analysis curves showed that the SO3H groups decompose earlier in the SPEEK–LiTFSI membranes than in pure SPEEK, owing to interactions between the Li+ ions and the SO3H groups. X‐ray diffraction and differential scanning calorimetry studies showed that the addition of LiTFSI decreased the crystallinity and the glass‐transition temperature of the polymer, which revealed the plasticizing effect of the lithium salt on the polymer matrix. The 7Li NMR spectroscopy results showed a single central transition line at around δ = –1.2 ppm, which indicated the presence of free mobile lithium ions. Dynamic mechanical analysis of the membrane showed it to be mechanically stable up to 100 °C, a prerequisite for flexible lithium polymer batteries. The highest room‐temperature conductivity in the order of 10–5 S cm–1 was observed for the 20 wt.‐% LiTFSI‐doped SPEEK membrane, which increased to 5 × 10–4 S cm–1 at 100 °C.
Enhanced Reactivity of Aerobic Diimide Olefin Hydrogenation with Arylboronic Compounds: An Efficient One‐Pot Reduction/Oxidation Protocol
Authors: Santra Surojit , Guin Joyram 
Published: October 2015

AbstractA catalyst‐free and efficient method for simultaneous olefin hydrogenation and oxidation of arylboronate esters to phenols with hydrazine hydrate and molecular oxygen is presented. The process is based on the utilization of a readily available Lewis acidic arylboron compound, which evades common problems associated with the catalyst‐free aerobic hydrogenation of olefins with diimide. Using an operationally simple procedure, the protocol smoothly delivers phenol derivatives and various alkanes in excellent yields with remarkable functional group compatibility. The method allows the reaction to be scaled up to 1 g of the starting materials.
Long‐term opioid therapy for chronic non‐cancer pain in Germany
Authors: Marschall U. , L'hoest H. , Radbruch L. , Häuser W. 
Published: October 2015

AbstractBackgroundNo data are available on the prevalence and predictors of (high‐dose) long‐term opioid therapy (LTOT) and on abuse/addiction of prescribed opioids by patients with chronic non‐cancer pain (CNCP) outside North America and Scandinavia.MethodsWe analysed randomly selected claims records of 870,000 persons (10% of insureds) in a large German medical health insurance organization during the fiscal year 2012.ResultsThe prevalence of LTOT prescriptions (defined by at least one opioid prescription per quarter for at least three consecutive quarters) for CNCP was 1.3% of all insureds. The mean daily dosage of LTOT was 58 (SD 79; minimum 0.3, maximum 2010) mg morphine equivalent/day. The percentage of insureds with high‐dose opioid prescriptions (≥100 mg morphine equivalent/day) among LTOT insureds was 15.5%. High‐dose LTOT (compared to traditional dose) prescription was associated with younger age, male gender, diagnoses of chronic pain disease, somatoform pain disorder, depression and prescription of anticonvulsants. The pooled 1‐year prevalence of abuse/addiction of prescribed opioids (defined by hospital stays because of mental and behavioural disorders due to alcohol, opioids, tranquilizers, multiple substances and intoxications by narcotic agents) was 0.56%. Abuse/addiction of prescribed opioids was associated with younger age, diagnoses of somatoform pain disorder, depression and prescription of tranquilizers.ConclusionsThe study found no signals of an ‘opioid epidemic’ in Germany. However, careful selection of patients with CNCP considered for LTOT and continuous evaluation during LTOT are warranted.
The association of total and central body fat with pain, fatigue and the impact of fibromyalgia in women; role of physical fitness
Authors: Segura‐Jiménez V. , Castro‐Piñero J. , Soriano‐Maldonado A. , Álvarez‐Gallardo I.C. , Estévez‐López F. , Delgado‐Fernández M. , Carbonell‐Baeza A. ,   the al‐Ándalus project.
Published: October 2015

AbstractBackgroundThe relationship between estimates of total and central body fat with fibromyalgia pain, fatigue and overall impact has not been fully described. We aimed to assess the individual and combined association of body fat (total and central) with pain, fatigue and the overall impact in fibromyalgia women; and to study the possible mediation role of physical fitness in these associations.MethodsA total of 486 fibromyalgia women with a mean (standard deviation) age of 52.2 (8.0) years participated. Pain was measured with self‐reported measures and algometry, whereas fatigue with the Multidimensional Fatigue Inventory. The impact of fibromyalgia was measured with the Revised Fibromyalgia Impact Questionnaire (FIQR) total score. Total and central body fat were assessed by means of bioelectrical impedance and waist circumference, respectively. The Functional Senior Fitness Test battery and the handgrip strength test were used to assess physical fitness.ResultsTotal and central body fat were positively associated with pain‐ and fatigue‐related measures and the FIQR total score (β from 0.10 to 0.25; all, p < 0.05). A combined effect of total and central body fat was observed on pain (FIQR and 36‐item Short‐Form Health Survey), general and physical‐related fatigue and FIQR total score (all, overall p < 0.05), so that the group with no total and central obesity had more favourable results than those with total and central obesity. Cardiorespiratory fitness partially mediated (between 22–40% of the total effect) the associations between total and central body fat with pain, general fatigue, physical fatigue and reduced activity, and largely mediated (80%) the association of central body fat with the FIQR total score.ConclusionsPhysical fitness might potentially explain the association between obesity and fibromyalgia symptoms.