bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foraminifera and Late Cenomanian-Turonian biostratigraphy of the northern palaeobiogeographic district of Western Siberia
Authors: Podobina Vera 
Published: October 2013

Abstract
The study of 114 core samples from seven borehole sections of the Van-Eganskaya area in the central part of Western Siberia yielded sufficient data to investigate the Late Cenomanian-Turonian foraminifers, palaeoenvironments, and the Late Cenomanian-Turonian biostratigraphy of this poorly studied area. Two Late Cenomanian foraminifer zones were established, viz. a (lower) Saccammina micra - Ammomarginulina sibirica Zone and an (upper) Trochammina wetteri tumida - Verneuilinoides kansasensis Zone. They reflect changes in the species composition of the foraminifer assemblages and lithology of the host rocks of the Uvatskian Horizon. In the lower part of the upper zone, beds with Gaudryinopsis nanushukensis elongatus are present. The changes in the species composition and lithology of the upper Cenomanian resulted from water-depth variations during the Boreal transgression. Two distinct assemblages and two homonymous zones, viz. the (lower) Gaudryinopsis angustus and the (upper) Pseudoclavulina hastata zones occur in the Turonian clayey cap-rocks of the superimposed Kuznetsovskian Horizon. Comparison of the Late Cenomanian-Turonian assemblages from the West-Siberian and Canadian provinces of the same Arctic palaeobiogeographical realm shows that the West-Siberian species are the same as, and closely related to, Canadian taxa, along with geographical subspecies. This comparison allows a detailed correlation, which results in a precise dating of the foraminifer zones.
The chevkinite group: underestimated accessory phases from a wide range of parageneses
Authors: Bagiński Bogusław , Macdonald Ray 
Published: October 2013

Abstract
Chevkinite-group minerals are widespread in a very wide range of igneous and metamorphic parageneses, forming important components of accessory mineral assemblages. Their presence in a rock may be difficult to establish by standard optical techniques, which has contributed to their importance being underestimated; a combination of SEM and EMPA is recommended here. Currently, there are eleven IMAapproved members of the group but undoubtedly several more will be described in the near future. There is considerable compositional variation in the group, which can be expressed as:
REE + M2+
C + M3+
C = Ca2+
A + Sr + Ti4+
C + Zr4+
C

where A and C are structural sites. Chevkinite-group minerals strongly fractionate geochemically coherent pairs, such as LREE-HREE, Nb-Ta, Zr-Hf and Th-U, and thus play a critical role in geochemical modelling.
Essential Killing fields of parabolic geometries: projective and conformal structures
Authors: Čap Andreas , Melnick Karin 
Published: October 2013

AbstractWe use the general theory developed in our article [Čap A., Melnick K., Essential Killing fields of parabolic geometries, Indiana Univ. Math. J. (in press)], in the setting of parabolic geometries to reprove known results on special infinitesimal automorphisms of projective and conformal geometries.
Langmuir isotherm models applied to the sorption of acid dyes from effluent onto polyamide nanofibers
Authors: Wang Yan , Wiener Jakub , Zhu Guocheng 
Published: October 2013

Abstract
The ability of polyamide 6 nanofibers membrane (P6NM) to remove acid dyes from effluent solution by adsorption has been studied. Equilibrium isotherms for the adsorption of three acid dyes, Acid blue 41 (AB41), Acid blue 78 (AB78), and Acid yellow 42 (AY42), on P6NM were measured experimentally. Simulated wastewater of acid dyes with the concentration of 10 mg/L for sorption process electrospun polyamide 6 with mass per unit area 12 g/m2 was used as the sorbent material. Ten sets of P6NM were dipped in separate simulated effluent. The weight of the original P6NM and the concentration of left solution were detected. Results were analyzed by the Langmuir equation using a linearized correlation coefficient. And it showed that all the dyes tested could follow the Langmuir adsorption isotherm, which gave excellent correlation for all the dyes.
Intravenous Immunoglobulin in Neonatal Sepsis
Authors: Li Jiang , Gautam Mahesh Kumar 
Published: October 2013

Neonatal sepsis remains the major cause of mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay in newborn infants. Despite of advances in technology and optimal antibiotic treatment, incidence of neonatal sepsis and its complications remains unacceptably high especially in developing countries. Premature neonates in particular are at higher risk due to developmentally immature host defense mechanisms. Though not approved by Food and Drug Administration (FDA) U.S.A, off label use of intravenous immunoglobulin continues in many countries. Recent evidences showed no significant decrease in the mortality rate or other outcomes when intravenous immunoglobulin is administered in addition to standard therapies. Hence, use of intravenous immunoglobulin in suspected or proven neonatal sepsis is not recommended. The expense of prophylactic use of intravenous immunoglobulin administration for both term and preterm newborn population, given the minimal benefit is not justified. Future studies are required which should focus on other prophylactic or adjuvant treatment modalities in addition to the standard therapy in neonatal sepsis. DOI: http://dx.doi.org/10.3126/jnps.v33i2.7400 J Nepal Paediatr Soc. 2013; 33(2):125-128
Management Issues of HIV Infection in Poor Resource Setting Due to Unavailability of Drug Sensitivity Testing
Authors: Ahmadu Baba Usman 
Published: October 2013

Despite the obvious benefits that rapid scale-up of antiretroviral therapy (ART) has had on cases of human immunodeficiency virus (HIV), treatment failure that is mostly associated with the emergence of HIV drug resistance still remains a major challenge. Index case is a stage 4 HIV patient who failed multiple ART, including nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs) and protease inhibitors (PIs). His clinical and immunological markers continued to fail despite completion of anti tuberculosis drugs, adequate nutrition, and treatment for opportunistic infections. This case indicates an emerging need to consider providing facility for HIV drug sensitivity testing at various sites in order to select appropriate second line antiretrovirals that would be of benefit to a patient. DOI: http://dx.doi.org/10.3126/jnps.v33i2.7699 J Nepal Paediatr Soc. 2013; 33(2):141-143
Clinical and Nutritional Assessment of Short Statured Indian Children with Celiac Disease
Authors: Mali Lalit P , Meena Shyam Sundar , Khatri Poonam Chand , Kumar T V Ram , Kumar Praveen 
Published: October 2013

Introduction: Celiac disease is an autoimmune disease, which is increasingly recognized as a cause of short stature in genetically susceptible population. The present study was undertaken to look for prevalence of celiac disease among the pediatric population with short stature (SS) and to study characteristics of these short statured children with celiac disease. Materials and Methods: This is a prospective study conducted at a tertiary teaching hospital at Bikaner, Rajasthan to look for the occurrence of celiac disease amongst the pediatric population (<15 years) with short stature (n=100). Other common causes of short stature were also identified. Results: Out of 100 short statured children, 38 (38%) had celiac disease and other major causes responsible were hypothyroidism, pituitary disorders, constitutional growth delay, and familial short stature. Chronic diarrhea, anorexia, anemia and behavioral changes were statistically more common in short statured children (<15 years) having celiac disease than non celiac patients. Conclusion: We conclude that celiac disease is not an uncommon cause of short stature and stunted growth in this region. All short statured patients should be screened for celiac disease. DOI: http://dx.doi.org/10.3126/jnps.v33i2.7912 J Nepal Paediatr Soc. 2013; 33(2):91-94
Role of CRP in Lower Respiratory Tract Infections
Authors: Kaur Jaskaranjot , Narang Gursharan Singh , Arora Sunita 
Published: October 2013

Introduction: Better diagnostic tests that establish the cause of LRTIs can reduce irrational antibiotic use. CRP is an acute phase protein that increases on inflammatory triggers can solve the purpose. The study aimed at role of CRP in distinguishing between bacterial and viral etiology. Materials and Methods: Fifty patients, aged 2 months to 5 years, with complaints of fever, cough and respiratory distress were included. Along with all other basic investigations like CBC, PBF, ESR, CRP Quantitative was also by Nycocard CRP Single Test for in vitro rapid determination. Results: In LRTI of probable bacterial aetiology mean CRP was 61.72 ±36.665 mg/l which was significantly higher than those with probable viral aetiology with mean CRP of 5.24 ±1.4 mg/l. The cut off level of CRP is taken as 9 mg/l with sensitivity of 100% and specificity of 96 %. Conclusion: CRP levels are both sensitive and specific for differentiating between viral and bacterial LRTI, thus reducing the overuse of antibiotics in clinical practice. DOI: http://dx.doi.org/10.3126/jnps.v33i2.8106 J Nepal Paediatr Soc. 2013; 33(2):117-120
Thrombocytopenia and Absent Radii (TAR) Syndrome in Non Identical Twins
Authors: Kage Anup , Marinova Jasmina 
Published: October 2013

This is a case report of female non identical twins with bilateral absent radii and severe thrombocytopenia. Genetic studies confirmed 1q21.1 deletion. A review of literature showed TAR syndrome in 2 pairs of identical twins (reported in 1986) and one pair of non identical twins (reported in 1979). DOI: http://dx.doi.org/10.3126/jnps.v33i2.8378 J Nepal Paediatr Soc. 2013; 33(2):150-151
Concentration et spécialisation sectorielle des cabinets d'audit sur le marché des sociétés cotées en 1997-1998
Authors: Piot Charles 
Published: October 2013

Cette étude analyse la concentration globale et sectorielle des cabinets d’audit, ainsi que les déterminants de la spécialisation sectorielle de l’auditeur nommé, pour les sociétés françaises cotées fin 1997. L’analyse descriptive montre une concentration globale de type oligopolistique, mais sensiblement moins élevée par rapport aux marchés anglo-saxons. Il existe des différences marquées entre secteurs d’activité qui ne semblent pas étrangères au degré de réglementation. Enfin, malgré la domination des Big Six , les grands réseaux nationaux (Majors) s’affirment comme une composante significative, possiblement grâce à l’obligation légale de cocommissariat. L’analyse déterministe révèle que la présence d’un auditeur spécialisé augmente avec la complexité organisationnelle de la firme ; et que l’appartenance à un secteur réglementé affecte positivement l’implication sectorielle des auditeurs nommés. Ces résultats appuient une demande de compétences spécifiques.
Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update
Authors: Wolff Antonio C. , Hammond M. Elizabeth H. , Hicks David G. , Dowsett Mitch , McShane Lisa M. , Allison Kimberly H. , Allred Donald C. , Bartlett John M.S. , Bilous Michael , Fitzgibbons Patrick , Hanna Wedad , Jenkins Robert B. , Mangu Pamela B. , Paik Soonmyung , Perez Edith A. , Press Michael F. , Spears Patricia A. , Vance Gail H. , Viale Giuseppe , Hayes Daniel F. 
Published: October 2013

Purpose.—To update the American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline recommendations for human epidermal growth factor receptor 2 (HER2) testing in breast cancer to improve the accuracy of HER2 testing and its utility as a predictive marker in invasive breast cancer.Methods.—ASCO/CAP convened an Update Committee that included coauthors of the 2007 guideline to conduct a systematic literature review and update recommendations for optimal HER2 testing.Results.—The Update Committee identified criteria and areas requiring clarification to improve the accuracy of HER2 testing by immunohistochemistry (IHC) or in situ hybridization (ISH). The guideline was reviewed and approved by both organizations.Recommendations.—The Update Committee recommends that HER2 status (HER2 negative or positive) be determined in all patients with invasive (early stage or recurrence) breast cancer on the basis of one or more HER2 test results (negative, equivocal, or positive). Testing criteria define HER2-positive status when (on observing within an area of tumor that amounts to &gt;10% of contiguous and homogeneous tumor cells) there is evidence of protein overexpression (IHC) or gene amplification (HER2 copy number or HER2/CEP17 ratio by ISH based on counting at least 20 cells within the area). If results are equivocal (revised criteria), reflex testing should be performed using an alternative assay (IHC or ISH). Repeat testing should be considered if results seem discordant with other histopathologic findings. Laboratories should demonstrate high concordance with a validated HER2 test on a sufficiently large and representative set of specimens. Testing must be performed in a laboratory accredited by CAP or another accrediting entity. The Update Committee urges providers and health systems to cooperate to ensure the highest quality testing.
Contre une littérature de l’épuisement
Authors: Decout Maxime 
Published: October 2013

Alors que le début du XXe siècle tend vers une intériorisation de l’aventure qui en diminue la prégnance au sein du réel, Albert Cohen choisit, avecSolal, de s’opposer à tout ce qui pourrait ressembler à une forme ou une autre de littérature de l’épuisement. Faisant du héros qu’est Solal le pivot du romanesque, ce récit tente le pari risqué de maintenir ensemble toutes les formes possibles de l’aventure : épique, chevaleresque, amoureuse, sociale, mythique, biblique, imaginaire, discursive, symbolique… Avec ce roman, Cohen multiplie, pour les essayer et les mettre à l’épreuve, les modèles intertextuels de l’aventure pour en refonder les possibilités. Dans ce jeu de tous les excès, c’est bien une autre façon de concevoir le roman qui est en germe et qui livrera tous ses fruits avec le chef-d’oeuvre de l’auteur,Belle du Seigneur.
Estudo transversal em escolares de 12 anos de idade sobre a necessidade de tratamento, etiologia e ocorrência de traumatismo dentário em Montes Claros, brasil.
Authors: Paiva Paula Cristina Pelli , Paiva Haroldo Neves de , Jorge Kelly Oliva , Filho Paulo Messias de Oliveira 
Published: October 2013

Objetivo: Avaliar a necessidade de tratamento, etiologia e o local de ocorrência do acidente que resultou em traumatismo dentário nos incisivos permanentes de escolares com 12 anos de idade, na cidade deMontes Claros. Materiais e Métodos: Para cálculo amostral utilizou-se a variabilidade populacional máxima (0,25), com nível de confiança de 95%, Zα/2 = 1,96; erro de estimação de 4%, d = 0,03. O tamanho daamostra mínima calculada foi 546 crianças, sendo acrescido de 10%, totalizando 638 crianças, selecionadas aleatoriamente nas escolas públicas e particulares. Em um primeiro momento foi investigada a prevalência detraumatismo dentário por meio de exames clínicos adotando a classificação Children´s Dental Health Survey do UK, realizado por um dentista treinado e calibrado (Kappa= 0,87 e 0,96). As crianças foram examinadas naescola sob luz artificial. Após os exames foi aplicado um questionário semi-estruturado direcionado às crianças a fim de investigar o conhecimento da ocorrência de traumatismo dentário, etiologia e local do acidente.Para obtenção dos resultados foi realizada análise descritiva e univariada (teste qui-quadrado). Resultados: A prevalência de traumatismos dentários foi de 34,9% em 605 exames clínicos realizados (94,8%). O traumatismodentário estava presente em 279 incisivos permanentes. A necessidade de tratamento restaurador foi observada em 35,8% dentes (n= 100), sendo que 13,97% deles apresentavam tratamento restaurador (n= 39). O principal fator etiológico foi a queda (49,7%) e a maioria dos escolares relatou que o traumatismo dentário havia ocorrido em casa (48,2%). Conclusão: A necessidade de tratamento restaurador devido ao traumatismo dentário foielevada e o principal fator etiológico foram as quedas ocorridas em casa.Descritores: Traumatismos dentários, Saúde bucal, Dentição permanente, Adolescente.
Metal‐Coordinated Polydopamine Structures for Tumor Imaging and Therapy
Authors: Wang Lihua , Song Kaiyue , Jiang Cong , Liu Shanping , Huang Shaorong , Yang Huang , Li Xianglong , Zhao Feng 
Published: July 2024

AbstractMeticulously engineered nanomaterials achieve significant advances in the diagnosis and therapy of solid tumors by improving tumor delivery efficiency; and thereby, enhancing imaging and therapeutic efficacy. Currently, polydopamine (PDA) attracts widespread attention because of its biocompatibility, simplicity of preparation, abundant surface groups, and high photothermal conversion efficiency, which can be applied in drug delivery, photothermal therapy, theranostics, and other nanomedicine fields. Inspired by PDA structures that are rich in catechol and amino functional groups that can coordinate with various metal ions, which have charming qualities and characteristics, metal‐coordinated PDA structures are exploited for tumor theranostics, but are not thoroughly summarized. Herein, this review summarizes the recent progress in the fabrication of metal‐coordinated PDA structures and their availabilities in tumor imaging and therapy, with further in‐depth discussion of the challenges and future perspectives of metal‐coordinated PDA structures, with the aim that this systematic review can promote interdisciplinary intersections and provide inspiration for the further growth and clinical translation of PDA materials.
Multifunctional Nanomesh Enables Cellular‐Resolution, Elastic Neuroelectronics
Authors: Ryu Jaehyeon , Qiang Yi , Chen Longtu , Li Gen , Han Xun , Woon Eric , Bai Tianyu , Qi Yongli , Zhang Shaopeng , Liou Jyun‐you , Seo Kyung Jin , Feng Bin , Fang Hui 
Published: July 2024

AbstractSilicone‐based devices have the potential to achieve an ideal interface with nervous tissue but suffer from scalability, primarily due to the mechanical mismatch between established electronic materials and soft elastomer substrates. This study presents a novel approach using conventional electrode materials through multifunctional nanomesh to achieve reliable elastic microelectrodes directly on polydimethylsiloxane (PDMS) silicone with an unprecedented cellular resolution. This engineered nanomesh features an in‐plane nanoscale mesh pattern, physically embodied by a stack of three thin‐film materials by design, namely Parylene‐C for mechanical buffering, gold (Au) for electrical conduction, and Poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulfonate) (PEDOT:PSS) for improved electrochemical interfacing. Nanomesh elastic neuroelectronics are validated using single‐unit recording from the small and curvilinear epidural surface of mouse dorsal root ganglia (DRG) with device self‐conformed and superior recording quality compared to plastic control devices requiring manual pressing is demonstrated. Electrode scaling studies from in vivo epidural recording further revealed the need for cellular resolution for high‐fidelity recording of single‐unit activities and compound action potentials. In addition to creating a minimally invasive device to effectively interface with DRG sensory afferents at a single‐cell resolution, this study establishes nanomeshing as a practical pathway to leverage traditional electrode materials for a new class of elastic neuroelectronics.
Controlled Migration of Lithium Cations by Diamine Bridges in Water‐Processable Polymer‐Based Solid‐State Electrolyte Memory Layers for Organic Synaptic Transistors
Authors: Lee Woongki , Kim Taehoon , Kim Hwajeong , Kim Youngkyoo 
Published: July 2024

AbstractSynaptic transistors require sufficient retention (memory) performances of current signals to exactly mimic biological synapses. Ion migration has been proposed to achieve high retention characteristics but less attention has been paid to polymer‐based solid‐state electrolytes (SSEs) for organic synaptic transistors (OSTRs). Here, OSTRs with water‐processable polymer‐based SSEs, featuring ion migration‐controllable molecular bridges, which are prepared by reactions of poly(4‐styrenesulfonic acid) (PSSA), diethylenetriamine (DETA), and lithium hydroxide (LiOH) are demonstrated. The ion conductivity of PSSA:LiOH:DETA (1:0.4:X, PLiD) films is remarkably changed by the molar ratio (X) of DETA, which is attributed to the extended distances between the PSSA chains by the DETA bridges. The devices with the PLiD layers deliver noticeably changed hysteresis reaching an optimum at X = 0.2, leading to the longest retention of current signals upon single/double pulses. The long‐term potentiation test confirms that the present OSTRs can gradually build up the postsynaptic current by gate pulses of −2 V, while the long‐term depression can be adjusted by varying the depression gate pulses (≈0.2–1.2 V). The artificial neural network simulations disclose that the present OSTRs with the ion migration‐controlled PLiD layers can perform synaptic processes with an accuracy of ≈96%.
Blue Laser Triggered Hemostatic Peptide Hydrogel for Gastrointestinal Bleeding Treatment
Authors: Luo Qiang , Luo Jie , Luan Zhaohui , Xu Kaige , Tian Lixing , Zhang Kebin , Peng Xue , Yuan Mengxue , Zheng Chuanhao , Shu Zhenzhen , Zhang Yuchen , Tan Shali , Dan Ruijue , Mequanint Kibret , Fan Chaoqiang , Xing Malcolm , Yang Shiming 
Published: July 2024

AbstractIn an emergency, nonvariceal upper gastrointestinal bleeding (NVUGIB), endoscopic hemostasis is considered the gold standard intervention. However, current endoscopic hemostasis is very challenging to manage bleeding in large‐diameter or deep lesions highly prone to rebleeding risk. Herein, a novel hemostatic peptide hydrogel (HPH) is reported, consisting of a self‐assembly peptide sequence CFLIVIGSIIVPGDGVPGDG (PFV) and gelatin methacryloyl (GelMA), which can be triggered by blue laser endoscopy (BLE) for nonvariceal upper gastrointestinal bleeding treatment without recurring bleeding concerns. Upon contact with GelMA solution, PFV immediately fibrillates into β‐sheet nanofiber and solvent‐induced self‐assembly to form HPH gel. HPH nanofiber networks induced ultrafast coagulation by enveloping blood cells and activating platelets and coagulation factors even to the blood with coagulopathy. Besides its remarkable hemostatic performance in artery and liver injury models, HPH achieves instant bleeding management in porcine NVUGIB models within 60 s by preventing the rebleeding risk. This work demonstrates an extraordinary hemostatic agent for NVUGIB intervention by BLE for the first time, broadening potential application scenarios, including patients with coagulopathy and promising clinical prospects.