bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enabling AI‐Generated Content for Gadolinium‐Free Contrast‐Enhanced Breast Magnetic Resonance Imaging
Authors: Wang Pingping , Wang Hongyu , Nie Pin , Dang Yanli , Liu Rumei , Qu Mingzhu , Wang Jiawei , Mu Gengming , Jia Tianju , Shang Lei , Zhu Kaiguo , Feng Jun , Chen Baoying 
Published: July 2024

BackgroundThere is increasing interest in utilizing AI‐generated content for gadolinium‐free contrast‐enhanced breast MRI.PurposeTo develop a generative model for gadolinium‐free contrast‐enhanced breast MRI and evaluate the diagnostic utility of the generated scans.Study TypeRetrospective.PopulationTwo hundred seventy‐six women with 304 breast MRI examinations (49 ± 13 years, 243/61 for training/testing).Field Strength/SequenceZOOMit diffusion‐weighted imaging (DWI), T1‐weighted volumetric interpolated breath‐hold examination (T1W VIBE), and axial T2 3D SPACE at 3.0 T.AssessmentA generative model was developed to generate contrast‐enhanced scans using precontrast T1W VIBE and DWI images. The generated and real images were quantitatively compared using the structural similarity index (SSIM), mean absolute error (MAE), and Dice similarity coefficient. Three radiologists with 8, 5, and 5 years of experience independently rated the image quality and lesion visibility on AI‐generated and real images within various subgroups using a five‐point scale. Four breast radiologists, with 8, 8, 5, and 5 years of experience, independently and blindly interpreted four reading protocols: unenhanced MRI protocol alone and combined with AI‐generated scans, abbreviated MRI protocol, and full‐MRI protocol.Statistical AnalysisResults were assessed using t‐tests and McNemar tests. Using pathology diagnosis as reference standard, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for each reading protocol. A P value <0.05 was considered significant.ResultsIn the test set, the generated images showed similarity to the real images (SSIM: 0.935 ± 0.047 [SD], MAE: 0.015 ± 0.012 [SD], and Dice coefficient: 0.726 ± 0.177 [SD]). No significant difference in lesion visibility was observed between real and AI‐generated scans of the mass, non‐mass, and benign lesion subgroups. Adding AI‐generated scans to the unenhanced MRI protocol slightly improved breast cancer detection (sensitivity: 92.86% vs. 85.71%, NPV: 76.92% vs. 70.00%); achieved non‐inferior diagnostic utility compared to the AB‐MRI protocol and full‐protocol (sensitivity: 92.86%, 95.24%; NPV: 75.00%, 81.82%).Data ConclusionAI‐generated gadolinium‐free contrast‐enhanced breast MRI has potential to improve the sensitivity of unenhanced MRI in detecting breast cancer.Evidence Level4Technical EfficacyStage 3
Enterovirus D68 disease burden and epidemiology in hospital‐admitted influenza‐like illness, Valencia region of Spain, 2014–2020 influenza seasons
Authors: Mengual‐Chuliá Beatriz , Tamayo‐Trujillo Rafael , Mira‐Iglesias Ainara , Cano Laura , García‐Esteban Sandra , Ferrús Maria Loreto , Puig‐Barberà Joan , Díez‐Domingo Javier , López‐Labrador F. Xavier ,   the VAHNSI network
Published: July 2024

AbstractEnterovirus D68 (EV‐D68) is an emerging agent for which data on the susceptible adult population is scarce. We performed a 6‐year analysis of respiratory samples from influenza‐like illness (ILI) admitted during 2014‐2020 in 4‐10 hospitals in the Valencia Region, Spain. EV‐D68 was identified in 68 (3.1%) among 2210 Enterovirus (EV)/Rhinovirus (HRV) positive samples. Phylogeny of 59 VP1 sequences showed isolates from 2014 clustering in B2 (6/12), B1 (5/12), and A2/D1 (1/12) subclades; those from 2015 (n = 1) and 2016 (n = 1) in B3 and A2/D1, respectively; and isolates from 2018 in A2/D3 (42/45), and B3 (3/45). B1 and B2 viruses were mainly detected in children (80% and 67%, respectively); B3 were equally distributed between children and adults; whereas A2/D1 and A2/D3 were observed only in adults. B3 viruses showed up to 16 amino acid changes at predicted antigenic sites. In conclusion, two EV‐D68 epidemics linked to ILI hospitalized cases occurred in the Valencia Region in 2014 and 2018, with three fatal outcomes and one ICU admission. A2/D3 strains from 2018 were associated with severe respiratory infection in adults. Because of the significant impact of non‐polio enteroviruses in ILI and the potential neurotropism, year‐round surveillance in respiratory samples should be pursued.
Impact of tourism destination image on perceived usefulness of online reviews: Psychological distance effect and two methodologies
Authors: Chang Minhui , Ko Eunhee Erica 
Published: July 2024

AbstractThis study aimed to empirically verify the impact of tourism destination image on perceived usefulness from the perspective of construal‐level theory. It also attempted to compare the results of the survey and data mining techniques regarding methodology. An online survey was initially conducted, and statistical analysis was performed using the R program. Concurrently, 25,952 reviews from TripAdvisor were gathered using a web crawler, Octoparse, and analyzed using the Tidyverse approach. The results indicated that, in the probabilistically distant group, affective destination image had a significant effect on perceived usefulness, whereas cognitive image did not affect perceived usefulness. Contrastingly, in the probabilistically close group, cognitive images had a stronger effect on perceived usefulness than affective images. Both the influential relationship between affective and cognitive images and the comparison of the two research methods were partially supported. These findings have theoretical and practical implications.
Comparison of Explainable Artificial Intelligence Model and Radiologist Review Performances to Detect Breast Cancer in 752 Patients
Authors: Oztekin Pelin Seher , Katar Oguzhan , Omma Tulay , Erel Serap , Tokur Oguzhan , Avci Derya , Aydogan Murat , Yildirim Ozal , Avci Engin , Acharya U. Rajendra 
Published: July 2024

ObjectivesBreast cancer is a type of cancer caused by the uncontrolled growth of cells in the breast tissue. In a few cases, erroneous diagnosis of breast cancer by specialists and unnecessary biopsies can lead to various negative consequences. In some cases, radiologic examinations or clinical findings may raise the suspicion of breast cancer, but subsequent detailed evaluations may not confirm cancer. In addition to causing unnecessary anxiety and stress to patients, such diagnosis can also lead to unnecessary biopsy procedures, which are painful, expensive, and prone to misdiagnosis. Therefore, there is a need for the development of more accurate and reliable methods for breast cancer diagnosis.MethodsIn this study, we proposed an artificial intelligence (AI)‐based method for automatically classifying breast solid mass lesions as benign vs malignant. In this study, a new breast cancer dataset (Breast‐XD) was created with 791 solid mass lesions belonging to 752 different patients aged 18 to 85 years, which were examined by experienced radiologists between 2017 and 2022.ResultsSix classifiers, support vector machine (SVM), K‐nearest neighbor (K‐NN), random forest (RF), decision tree (DT), logistic regression (LR), and XGBoost, were trained on the training samples of the Breast‐XD dataset. Then, each classifier made predictions on 159 test data that it had not seen before. The highest classification result was obtained using the explainable XGBoost model (X2GAI) with an accuracy of 94.34%. An explainable structure is also implemented to build the reliability of the developed model.ConclusionsThe results obtained by radiologists and the X2GAI model were compared according to the diagnosis obtained from the biopsy. It was observed that our developed model performed well in cases where experienced radiologists gave false positive results.
Lateral to medial fluoroscopic view improves the accuracy of identifying the MPFL femoral footprint using Schottle's technique
Authors: Cetin Hakan , Kose Ozkan , Selcuk Huseyin , Egerci Omer Faruk , Kilic Koray Kaya , Sarikcioglu Levent 
Published: July 2024

AbstractPurposeThis study investigated the effect of different fluoroscopy settings on the accuracy of locating Schottle's point during medial patellofemoral ligament (MPFL) reconstruction.MethodsThe centre of the MPFL femoral footprint was identified and marked on 44 dry femurs. Two standard true lateral knee fluoroscopic images were obtained: (1) medial to lateral (ML) and (2) lateral to medial (LM). The deviation between the anatomically determined MPFL femoral footprint and the fluoroscopically identified point was measured on both fluoroscopic images. An ‘acceptable tunnel location’ was defined as within a 5‐ or 7‐mm margin of error from the anatomic MPFL footprint. Distal femoral morphometric dimensions were also measured using digital calipers. Statistical analysis determined discrepancies between techniques and their relation to femoral morphometry.ResultsThe LM view yielded a significantly smaller distance between the anatomical MPFL footprint and Schottle's point compared to the ML view (3.2 ± 1.5 vs. 4.5 ± 2.1 mm, p < 0.001). The LM view achieved acceptable tunnel locations, meeting the 5‐mm error criterion in 90.9% of cases, while the ML view achieved 65.9% (p < 0.001). Both views yielded acceptable tunnel locations at similar rates using the 7‐mm error criterion (n.s.). The anatomic MPFL footprint was displaced towards the anterior and proximal location in the ML view in reference to the Schottle point. No correlation was observed between any of the morphometric measurements and the deviations.ConclusionsThis study demonstrated that using the LM fluoroscopic view improves the accuracy of femoral tunnel placement when identifying the MPFL footprint via the Schottle technique. Adopting the LM view in surgical practice will help surgeons locate the anatomical femoral footprint accurately, replicating the native MPFL and enhancing clinical outcomes.Level of EvidenceLevel 4, cadaveric study.
The Greco‐Roman Contribution to Lifestyle Medicine
Authors: Panegyres Konstantine 
Published: July 2024

ABSTRACTBackgroundLifestyle has become a major and well‐recognized aspect of modern healthcare, but there is little awareness of the origins of lifestyle medicine.ResultsThis paper shows that a major contribution to lifestyle medicine was made by Greco‐Roman physicians. Ancient Greek and Roman doctors placed considerable emphasis on the role lifestyle played in determining the state of their patients’ health.
Fine‐grained sediment production by endolithic sponges on Caribbean coral reefs
Authors: de Bakker Didier M. , Perry Chris T. , Magaña‐Gallegos Eden , Pérez‐Cervantes Esmeralda , Alvarez‐Filip Lorenzo 
Published: July 2024

AbstractEndolithic sponges are key players in carbonate cycling on coral reef systems. While their bioerosion of reef framework is relatively well studied, their role in biogenic sediment generation is poorly understood. In this study, the sedimentary attributes and production rates of eight Caribbean endolithic sponge species were characterized. The findings revealed notable species‐specific variations in sediment production rates (range: 1.0–6.3 kg CaCO3 m−2 yr−1), alongside consistency in sediment characteristics (modal sizes ranging from 39 to 48 μm). The species‐specific rates were used to explore reef‐scale variations in sponge‐derived sediment generation across 50 reef sites in the Mexican Caribbean. Significant between‐site variability was observed, with estimated annual sediment production ranging from < 0.01 to 0.84 kg m−2 of reef. Production was primarily driven by sponge abundance, with discernible spatial variations in the contributions of different species, which could be related to variability in local environmental conditions. The rapidity at which these sediment producers can utilize dead coral substrates, coupled with their positive response to the changing marine environment, highlights the growing importance of these sponges in modern degraded Caribbean reef systems.
Parkinson's Disease Gene Screening in Familial Cases from Central and South America
Authors: Lorenzo‐Betancor Oswaldo , Mehta Seysha , Ramchandra Janvi , Mumuney Sekinat , Schumacher‐Schuh Artur F. , Cornejo‐Olivas Mario , Sarapura‐Castro Elison H. , Torres Luis , Inca‐Martinez Miguel A. , Mazzetti Pilar , Cosentino Carlos , Micheli Federico , Tumas Vitor , Dieguez Elena , Raggio Victor , Borges Vanderci , Ferraz Henrique B. , Chana‐Cuevas Pedro , Jimenez‐Del‐Rio Marlene , Velez‐Pardo Carlos , Moreno Sonia , Lopera Francisco , Orozco‐Velez Jorge L. , Muñoz‐Ospina Beatriz , Rieder Carlos R.M. , Medina‐Escobar Alex , Yearout Dora , Zabetian Cyrus P. , Mata Ignacio F. ,   Latin American Research Consortium on the Genetics of PD (LARGE‐PD)
Published: July 2024

AbstractBackgroundParkinson's disease (PD) is the second most common neurodegenerative disease following Alzheimer's disease. Nearly 30 causative genes have been identified for PD and related disorders. However, most of these genes were identified in European‐derived families, and little is known about their role in Latin American populations.ObjectivesOur goal was to assess the spectrum and frequency of pathogenic variants in known PD genes in familial PD patients from Latin America.MethodsWe selected 335 PD patients with a family history of PD from the Latin American Research Consortium on the Genetics of PD. We capture‐sequenced the coding regions of 26 genes related to neurodegenerative parkinsonism. Of the 335 PD patients, 324 had sufficient sequencing coverage to be analyzed.ResultsWe identified pathogenic variants in 41 individuals (12.7%) in FBXO7, GCH1, LRRK2, PARK7, PINK1, PLA2G6, PRKN, SNCA, and TARDBP, GBA1 risk variants in 25 individuals (7.7%), and variants of uncertain significance in another 24 individuals (7.4%) in ATP13A2, ATP1A3, DNAJC13, DNAJC6, GBA1, LRKK2, PINK1, VPS13C, and VPS35. Of the 70 unique variants identified, 19 were more frequent in Latin Americans than in any other population.ConclusionsThis is the first screening of known PD genes in a large cohort of patients with familial PD from Latin America. There were substantial differences in the spectrum of variants observed in comparison to previous findings from PD families of European origin. Our data provide further evidence that differences exist between the genetic architecture of PD in Latinos and European‐derived populations. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Prokineticin‐2 Is Highly Expressed in Colonic Mucosa of Early Parkinson's Disease Patients
Authors: Bellini Gabriele , Rettura Francesco , Palermo Giovanni , Ippolito Chiara , Segnani Cristina , Pierucci Clarissa , Fontanelli Lorenzo , Frosini Daniela , Nardini Vincenzo , Lambiase Christian , Bernardini Nunzia , Pellegrini Carolina , Ceravolo Roberto 
Published: July 2024

AbstractBackgroundElevated levels of prokineticin‐2 (PK2), regarded as a protein involved in modulating immune/inflammatory responses, have been detected in the substantia nigra, serum, and olfactory neurons of Parkinson's disease (PD) patients. Of note, emerging evidence suggests that gut alterations, including dysbiosis and enteric inflammation, play a role in PD via the gut‐brain axis.ObjectivesOur goal was to investigate the expression of PK2 in colonic biopsies of PD patients.MethodsMucosal biopsies from the descending colon were obtained in 11 PD patients and five asymptomatic subjects. Biopsy samples were processed for PK2 immunofluorescence and western blot.ResultsWe revealed an increased PK2 expression in colonic mucosa from PD patients in the early stages compared to controls. In addition, we found that PK2 was expressed by activated enteric glial cells and macrophages.ConclusionsPK2 is highly expressed within neurogenic/inflammatory cells of colonic mucosa from early PD patients, suggesting a potential role of PK2 in gut inflammation, especially in the early stages of PD. © 2024 International Parkinson and Movement Disorder Society.
Persistent response to combination treatment of pemigatinib and chemotherapy in a patient with advanced gastric cancer: A case report
Authors: Wu Jing , Cui Yuehong , Yu Shan 
Published: July 2024

AbstractObjectiveThis study aimed to report the treatment and outcomes of a patient with advanced gastric cancer (GC) using a combination of a targeted molecular therapy and chemotherapy.Patients and methodsA 40‐year‐old woman presented with abdominal metastatic nodules and peritoneal effusion. Biopsy and cytology identified signet ring cell carcinoma. Ten months after the onset of initial symptoms, gastroscopy confirmed signet ring cell carcinoma of the gastric body. Genetic testing revealed amplification of the fibroblast growth factor receptor (FGFR) gene. Consequently, the patient received FGFR inhibitor pemigatinib in addition to a chemotherapy regimen of albumin paclitaxel plus 5‐fluorouracil.ResultsDuring the treatment, the patient experienced recurrent liver function abnormalities and intestinal obstruction, which were managed with symptom‐specific medications and supportive therapies. The combined treatment regimen resulted in a progression‐free survival (PFS) period of ten months.ConclusionThe integration of FGFR inhibitor pemigatinib with standard chemotherapy showed promising results in prolonging PFS in a patient with advanced GC characterized by FGFR gene amplification, despite the occurrence of manageable side effects.
Face stability assessment of a longitudinally inclined tunnel considering pore water pressure
Authors: Chen Guang‐Hui , Zou Jin‐Feng , Guo Yuan‐Cheng , Tan Zi‐An , Dan Shu 
Published: July 2024

AbstractThe face stability analysis of a longitudinally inclined shield tunnel using an analytical approach in water‐rich areas is still a research gap. To solve this face stability problem, a numerical simulation based on the FLAC3D is first conducted to calculate the seepage field behind the inclined tunnel face. An improved rotational failure mechanism is developed to make it possible to investigate the face stability of inclined tunnels using analytical approaches. In the framework of the kinematic approach of limit analysis, the limit support pressures and corresponding failure surfaces of the inclined tunnel face are determined to analyze the face stability issue. The interpolation tool (griddata) in MATLAB is adopted to involve the obtained numerical values of pore water pressures into the analysis of the stability issue. The analytical solutions obtained from the proposed method are validated by comparisons with existing results from published literatures and numerical results. For a quick estimation of the inclined tunnel face stability in water‐rich areas, a series of design charts are then presented for various soil strength parameters, water tables, and inclined angles. Finally, an application of the proposed method to a practical tunneling case is provided, which further illustrates the effectiveness of the proposed method.
MRI assessment of adipose tissue fatty acid composition in the UK Biobank and its association with diet and disease
Authors: Thanaj Marjola , Basty Nicolas , Whitcher Brandon , Bell Jimmy D. , Thomas E. Louise 
Published: July 2024

AbstractObjectiveThis study aimed to assess the fatty acid (FA) composition of abdominal subcutaneous and visceral adipose tissue (ASAT and VAT, respectively) in the UK Biobank imaging cohort (N = 33,823) using magnetic resonance imaging (MRI).MethodsWe measured the fractions of saturated, monounsaturated, and polyunsaturated FA (fSFA, fMUFA, and fPUFA, respectively) in ASAT and VAT from multiecho MRI scans. We selected a subcohort of participants who followed a vegan and an omnivore diet (N = 36) to validate the effect of diet on adipose tissue. In the wider imaging cohort, we examined the relationships between adipose tissue FA composition and various traits related to disease and body size.ResultsWe measured adipose tissue FA composition for over 33,000 participants, revealing higher fSFA and fPUFA and lower fMUFA in VAT (p < 0.00016). fMUFA and fPUFA were higher in ASAT and lower in VAT for women (p < 0.00016). Vegan participants exhibited lower fSFA in both ASAT and VAT (p < 0.00016). VAT fSFA and fMUFA showed significant associations with disease, as well as anthropometric variables.ConclusionsThis extensive analysis revealed the relationships between adipose tissue FA composition and a range of factors in a diverse population, highlighting the importance of studying body adipose tissue beyond its quantity.
Green thermal insulators: A review into the role of biopolymer‐based aerogels in thermal insulation applications
Authors: Giuma Abdussalam , Khalil H. P. S. Abdul , Yahya Esam Bashir , Sukeksi Lilis , Alfatah Tata , Nurazzi N. M. , Jaber Mohamed , Surya Indra 
Published: July 2024

AbstractThe need for green thermal insulation materials, such as biopolymer aerogels, has become increasingly critical in the face of escalating environmental concerns and the urgent push toward sustainable practices. The unique characteristics of biopolymer aerogels, coupled with their environmental benefits, position them as potential disruptors in the insulation industry. As research continues, addressing challenges and refining fabrication techniques will likely lead to wider adoption of these materials, contributing to a greener and more energy‐efficient built environment. This review presents the latest developments concerning the properties and versatile applications of biopolymer‐based thermal insulators as a new type of green materials. It comprehensively examines the fundamental principles of thermal insulation, factors that influence its efficacy, and the compatibility and mechanisms underlying bioaerogels within this context. The review also addresses the latest works about the utilization of different biopolymer aerogels in different thermal insulation applications and critically assesses the obstacles currently faced by biopolymer‐based aerogels and elucidates potential avenues for future advancement.Highlights
Biopolymer aerogels offer a sustainable alternative in insulation.
Challenges in production limit current aerogel adoption rates.
Latest advancements highlight aerogels' versatile insulation applications.
Future research aims to enhance biopolymer aerogel technology and use.