bluuebunny/crossref_metadata_2025_split huggingface dataset:
Réflexions sur le choix du manuscrit de base aujourd’hui ou La précaution inutile ?
Authors: Delsaux Olivier , Hemelryck Tania Van 
Published: October 2012

Cet article propose une réflexion sur les enjeux actuels du choix du manuscrit de base dans les éditions de textes en moyen français. Il vise notamment à mesurer la place qu’occupe et que peut occuper l’approche externe du manuscrit dans l’évaluation de son utilité éditoriale. Sont plus particulièrement envisagés les critères suivants : technologie (manuscrit vs imprimé), facture, support, calligraphie, illustration, producteur, premier possesseur, dédicataire, lecteur. L’article offre ainsi un panorama de la façon dont les sciences auxiliaires de l’archéologie du livre ont influencé les cadres théoriques et pratiques de la philologie française depuis les trente dernières années.
Contribution of Pulmonary KLRG1high and KLRG1low CD8 T Cells to Effector and Memory Responses during Influenza Virus Infection
Authors: Ye Fang , Turner Joanne , Flaño Emilio 
Published: October 2012

Abstract
In response to pathogen insult, CD8 T cells undergo expansion and a dynamic differentiation process into functionally different subpopulations. In this study, we show that during the effector response to influenza virus infection lung CD8 T cell subsets expressing killer cell lectin-like receptor G1 (KLRG1)high or KLRG1low had similar effector functions and immediate recall efficacy. The KLRG1 expression profile of lung CD8 T cells was not permanent after adoptive transfer and recall. Airway CD8 T cells exhibited a unique phenotype expressing low levels of KLRG1 together with high levels of markers of cellular activation. We investigated the functional characteristics of these cells by analyzing their capacity to survive and to respond to a secondary challenge outside of the airway environment. KLRG1high CD8 T cells isolated from the lung during the peak of the effector T cell response could survive for more than a month in the absence of cognate viral Ags after systemic adoptive transfer, and these “rested” CD8 T cells proliferated and participated in a recall response to influenza virus infection. These data highlight the unique phenotype and plasticity of effector CD8 T cell responses in the lung.
GM-CSF and IL-4 Stimulate Antibody Responses in Humanized Mice by Promoting T, B, and Dendritic Cell Maturation
Authors: Chen Qingfeng , He Fang , Kwang Jimmy , Chan Jerry K. Y. , Chen Jianzhu 
Published: October 2012

Abstract
Engraftment of human hematopoietic stem cells into immunodeficient mice that lack T cells, B cells, and NK cells results in reconstitution of human blood lineage cells, especially B cells, in the recipient mice. However, these humanized mice do not make any significant level of IgG Ab in response to Ag stimulation. In this study, we show that in humanized mice, B cells are immature, and there is a complete deficiency of CD209+ (DC-SIGN) human dendritic cells. These defects can be corrected by expression of human GM-CSF and IL-4 in humanized mice. As a result, these cytokine-treated humanized mice produced significant levels of Ag-specific IgG after immunization, including the production of neutralizing Abs specific for H5N1 avian influenza virus. A significant level of Ag-specific CD4 T cell response was also induced. Thus, we have identified defects in humanized mice and devised approaches to correct these defects such that the platform can be used for studying Ab responses and to generate novel human Abs against virulent pathogens and other clinically relevant targets.
Prosthetic Joint Infections due to Staphylococcus Aureus and Coagulase-Negative Staphylococci
Authors: Tornero Eduard , García-Oltra Ester , García-Ramiro Sebastían , Martínez-Pastor Juan C. , Bosch Jordi , Climent Consuelo , Morata Laura , Camacho Pilar , Mensa Josep , Soriano Alex 
Published: October 2012

Purposes To evaluate the specific characteristics, outcome, and predictors of failure of prosthetic joint infections (PJI) due to S. aureus and coagulase-negative staphylococci (CNS) treated with open debridement and retention of the implant. Methods PJI due to S. aureus or CNS prospectively registered in a database from 1999 to 2009 were retrospectively reviewed. During the study period, 106 patients met the inclusion criteria. The mean follow-up period was 3.8 years and for at least 2 years in all patients. The failure rate was 23.6% (25 out of 106). The only variable significantly associated with failure in the global cohort was polymicrobial infection (38.7% vs. 17.3%, p = 0.024). Fifty-seven (53.8%) patients had an infection due to S. aureus and 49 (46.2%) due to CNS. Among S. aureus infections, 95% corresponded to primary arthroplasties while 98% of PJIs due to CNS were after revision arthroplasties (p<0.001). C-reactive protein was significantly higher in PJI due to S. aureus (9.5 mg/dl vs. 4.9 mg/dl, p = 0.007). The rate of methicillin-resistance (8.8% vs. 59.2%, p<0.001) and fluoroquinolone-resistance (15.8% vs. 34.7%, p = 0.005) was significantly higher in CNS infections. The global failure rate was higher in S. aureus infections (28% vs. 18.3. p = 0.26). In S. aureus infections, patients diagnosed within the first 15 days after joint arthroplasty (p = 0.031) and with bacteremia (p = 0.046) had poor prognosis. In CNS infections only the location of the prosthesis (knee 27.6% vs. hip 5%, p = 0.045) was associated with failure. Conclusions PJIs due to S. aureus were mainly in primary arthroplasties; they had a higher inflammatory response; and the strains were more susceptible to fluoroquinolones and methicillin than CNS infections. S. aureus infections had a higher failure rate than CNS infections, however, the difference was not statistically significant. There were few factors associated with failure and they were different in S. aureus and CNS infections.
Folk Illusions: An Unrecognized Genre of Folklore
Authors: Barker K. Brandon , Rice Claiborne 
Published: October 2012

Abstract
Pulling from previous works on childlore, recently gathered adult remembrances, and systematic observations of children, the authors identify a heretofore unrecognized category of folklore we call folk illusions. Folk illusions are traditionalized, communicative performances that consistently effect an intended embodied illusion for one or more participants. Describing four types of folk illusions, the authors outline the salient features of the category--namely, director and actor roles, performance positions, priming periods, and verbal continuum. We argue that folk illusions are an under-studied aspect of embodiment and community in folkloristics and related epistemological fields. Ultimately, we contend that the study of folk illusions furthers our understanding of both illusions and folkloric intersubjectivity.
Bull Sharks in North Carolina
Authors: Schwartz Frank J. 
Published: October 2012

Abstract
A total of 113 bull sharks, Carcharhinus leucas, frequented North Carolina waters between 1965 and 2011. Young entered Pamlico Sound, adults were captured throughout the year, most commonly May to September, and frequented fresh to ocean waters. Bull sharks have caused nine attacks between 1990 and 2011, all victims but one survived.
Functional Limitations Due to Axial and Peripheral Joint Impairments in Patients With Ankylosing Spondylitis: Are Focused Measures More Informative?
Authors: Bethi Siddharth , Dasgupta Abhijit , Weisman Michael H. , Learch Thomas J. , Gensler Lianne S. , Davis John C. , Reveille John D. , Ward Michael M. 
Published: October 2012

AbstractObjectiveFunctional limitations in ankylosing spondylitis (AS) may be due to peripheral joint or axial involvement. To determine if the Bath Ankylosing Spondylitis Functional Index (BASFI), an axial‐focused measure, can detect limitations related to peripheral joint involvement equally as well as the Health Assessment Questionnaire modified for the spondyloarthropathies (HAQ‐S), a peripheral arthritis–focused measure, and vice versa, we compared associations of each questionnaire with spinal and hip range of motion, peripheral arthritis, and enthesitis in patients with AS.MethodsWe examined patients every 4–6 months in this prospective longitudinal study. We used mixed linear models to analyze the associations between 10 physical examination measures and the BASFI and HAQ‐S.ResultsWe studied 411 patients for a median of 1.5 years (median 3 visits). In multivariate analyses, cervical rotation, chest expansion, lateral thoracolumbar flexion, hip motion, tender joint count, and tender enthesis count were equally strongly associated with the BASFI and HAQ‐S. Peripheral joint swelling was more strongly associated with the HAQ‐S. Individual items of the BASFI were more likely than items of the HAQ‐S to be associated with unrelated physical examination measures (e.g., the association between difficulty rising from a chair and cervical rotation), which may have diminished the axial/peripheral distinction for the BASFI.ConclusionThe BASFI and HAQ‐S had similar associations with impairments in axial measures, while the HAQ‐S had stronger associations with the number of swollen peripheral joints. The HAQ‐S should be considered for use in studies focused on spondyloarthritis with peripheral joint involvement.
A rule‐based model for integrated operation of bus priority signal timings and traveling speed
Authors: Ma Wanjing , Liu Yue , Han Baoxin 
Published: October 2012

SUMMARYThis paper focuses on integrated operation of signal timings and bus speed to provide priority to buses at isolated intersections when real‐time adjustment of bus speed is available (e.g., through Connected Vehicle). Most previous work assumes that the speed of a bus is given as an exogenous input and focuses merely on optimization of signal timings. The bus‐passing window and the bus‐arriving window are defined with respect to the real‐time signal status and bus arrivals to capture explicitly the interaction between bus speed and transit priority signal timings. A set of integrated operational rules is developed on the basis of these windows for buses with and without schedule deviation with the objective of minimizing bus schedule deviation, bus fuel consumption, and emissions. Four subsets are included: impacts of preceding bus analysis rules, priority requests generation rules, priority passing rules, and speed adjustment without priority rules. A VISSIM‐based simulation platform was designed and used for simulating and evaluating the proposed method. Extensive experimental analyses have shown that the proposed rule‐based integrated operational approach outperforms the no priority and conventional priority strategies (no bus speed adjustment) in terms of reducing bus delays, improving schedule adherence, saving energy, reducing emission, and minimizing the impacts on general traffic. The sensitivity analysis has further demonstrated the potential of the proposed approach to be applied in real‐time bus priority control system under different levels of transit and traffic demand. Copyright © 2012 John Wiley & Sons, Ltd.
Multimodality image fusion to guide peripheral artery chronic total arterial occlusion recanalization in a swine carotid artery occlusion model: Unblinding the interventionalist
Authors: Klein Andrew J. , Tomkowiak Michael T. , Vigen Karl K. , Hacker Timothy A. , Speidel Michael A. , VanLysel Michael S. , Shah Nehal , Raval Amish N. 
Published: October 2012

AbstractObjectivesTo demonstrate the feasibility of magnetic resonance imaging (MRI) to X‐ray fluoroscopy (XRF) image fusion to guide peripheral artery chronic total occlusion (CTO) recanalization.BackgroundEndovascular peripheral artery CTO revascularization is minimally invasive, but challenging, because the occlusion is poorly visualized under XRF. Devices may steer out of the artery, which can lead to severe perforation. Merging preacquired MRI of the CTO to the live XRF display may permit upfront use of aggressive devices and improve procedural outcomes.MethodsSwine carotid artery CTOs were created using a balloon injury model. Up to 8 weeks later, MRI of the carotid arteries was acquired and segmented to create three‐dimensional surface models, which were then registered onto live XRF. CTO recanalization was performed using incrementally aggressive CTO devices (group A) or an upfront aggressive directed laser approach (group B). Procedural success was defined as luminal or subintimal device position without severe perforation.ResultsIn this swine model, MRI to XRF fusion guidance resulted in a procedural success of 57% in group A and 100% in group B, which compared favorably to 33% using XRF alone. Fluoroscopy time was significantly less for group B (8.5 ± 2.6 min) compared to group A (48.7 ± 23.9 min), P < 0.01. Contrast dose used was similar between groups A and B.ConclusionsMRI to XRF fusion‐guided peripheral artery CTO recanalization is feasible. Multimodality image fusion may permit upfront use of aggressive CTO devices with improved procedural outcomes compared to XRF‐guided procedures. © 2012 Wiley Periodicals, Inc.
Stereoselective Determination of Metoprolol and its Metabolite α‐Hydroxymetoprolol in Plasma by LC‐MS/MS: Application to Pharmacokinetics during Pregnancy
Authors: Antunes Natalícia De Jesus , Cavalli Ricardo Carvalho , Marques Maria Paula , Lanchote Vera Lucia 
Published: October 2012

ABSTRACTMetoprolol is available for clinical use as a racemic mixture. The S‐(−)‐metoprolol enantiomer is the one expressing higher activity in the blockade of the β1‐adrenergic receptor. The α‐hydroxymetoprolol metabolite also has activity in the blockade of the β1‐adrenergic receptor. The present study describes the development and validation of a stereoselective method for sequential analysis of metoprolol and of α‐hydroxymetoprolol in plasma using high‐performance liquid chromatography with tandem mass spectrometry (LC‐MS/MS). 1‐ml aliquots of plasma were extracted with dichloromethane : diisopropyl ether (1:1, v/v). Metoprolol enantiomers and α‐hydroxymetoprolol isomers were separated on a Chiralpak AD column (Daicel Chemical Industries, New York, NY, USA) and quantitated by LC‐MS/MS. The limit of quantitation obtained was 0.2 ng of each metoprolol enantiomer/ml plasma and 0.1 ng/ml of each α‐hydroxymetoprolol isomer/ml plasma. The method was applied to the study of kinetic disposition of metoprolol in plasma samples collected up to 24 h after the administration of a single oral dose of 100‐mg metoprolol tartrate to a hypertensive parturient with a gestational age of 42 weeks. The clinical study showed that the metoprolol pharmakokinetics is enantioselective, with the observation of higher area under the curve (AUC)0−∞ values for S‐(−)‐metoprolol (AUCS‐(−)/AUCR‐(+) = 1.81) and the favoring of the formation of the new chiral center 1′R of α‐hydroxymetoprolol (AUC0−∞1′R/1′S = 2.78). Chirality, 25:1–7, 2013. © 2012 Wiley Periodicals, Inc.
Aromatic Core Extension in the Series of N‐Cyclic Bay‐Substituted Perylene G‐Quadruplex Ligands: Increased Telomere Damage, Antitumor Activity, and Strong Selectivity for Neoplastic over Healthy Cells
Authors: Franceschin Marco , Rizzo Angela , Casagrande Valentina , Salvati Erica , Alvino Antonello , Altieri Alessandro , Ciammaichella Alina , Iachettini Sara , Leonetti Carlo , Ortaggi Giancarlo , Porru Manuela , Bianco Armandodoriano , Biroccio Annamaria 
Published: October 2012

AbstractBased on previous work on both perylene and coronene derivatives as G‐quadruplex binders, a novel chimeric compound was designed: N,N′‐bis[2‐(1‐piperidino)‐ethyl]‐1‐(1‐piperidinyl)‐6‐[2‐(1‐piperidino)‐ethyl]‐benzo[ghi]perylene‐3,4:9,10‐tetracarboxylic diimide (EMICORON), having one piperidinyl group bound to the perylene bay area (positions 1, 12 and 6, 7 of the aromatic core), sufficient to guarantee good selectivity, and an extended aromatic core able to increase the stacking interactions with the terminal tetrad of the G‐quadruplex. The obtained “chimera” molecule, EMICORON, rapidly triggers extensive DNA damage of telomeres, associated with the delocalization of telomeric protein protection of telomeres 1 (POT1), and efficiently limits the growth of both telomerase‐positive and ‐negative tumor cells. Notably, the biological effects of EMICORON are more potent than those of the previously described perylene derivative (PPL3C), and more interestingly, EMICORON appears to be detrimental to transformed and tumor cells, while normal fibroblasts expressing telomerase remain unaffected. These results identify a new promising G‐quadruplex ligand, structurally and biologically similar on one side to coronene and on the other side to a bay‐monosubstituted perylene, that warrants further studies.
Development of a Metabolically Stable Neurotensin Receptor 2 (NTS2) Ligand
Authors: Held Cornelia , Plomer Manuel , Hübner Harald , Meltretter Jasmin , Pischetsrieder Monika , Gmeiner Peter 
Published: October 2012

AbstractSubtype‐selective neurotensin receptor 2 (NTS2) ligands can be used as molecular probes to investigate the physiological role of neurotensinergic systems and serve as lead compounds to initiate the development of drugs for the treatment of tonic pain. Starting from our recently described NTS2 ligand 1, structural variants of type 2 were synthesized to further improve binding affinity and selectivity to gain metabolic stability. The peptide–peptoid hybrid 2 b showed excellent NTS2 binding affinity (Ki=2.8 nM) and 22 000‐fold selectivity over NTS1, as well as metabolic stability over 32 h in a serum degradation assay. Employing a MAPK‐driven luciferase reporter gene assay and an IP accumulation assay, the neurotensin mimetic 2 b displayed respective inhibitions of constitutive activity exceeding 4.3‐ and 3.9‐fold that of the inverse agonist activity of the endogenous ligand neurotensin.
Electrochemically Induced Release of a Luminescent Probe from a Rhenium‐Containing Metallopolymer
Authors: Valenti Giovanni , O'Reilly Emmet J , McNally Andrea , Keyes Tia E. , Marcaccio Massimo , Paolucci Francesco , Forster Robert J. 
Published: October 2012

AbstractThe photophysical and electrochemical properties of a novel metallopolymer containing [Re(bpy)(CO)3]+ moieties coordinated to a poly(4‐vinylpyridine) polymer chain are reported. Significantly, the release of the metal complexes can be triggered by oxidation or reduction of the rhenium complex. Solvent rapidly binds to the vacant coordination site to give a luminescent product. The redox and photophysical properties of the parent metallopolymer and the released solvated complex are compared. Along with photoemission, the metallopolymer generates significant electrogenerated chemiluminescence upon reduction in the presence of benzoyl peroxide as coreactant.
Tuning Fluorescent Molecules by Inclusion in a Metal–Organic Framework: An Experimental and Computational Study
Authors: Yan Dongpeng , Lloyd Gareth O. , Delori Amit , Jones William , Duan Xue 
Published: October 2012

AbstractFluorescent molecules included within a metal–organic framework (MOF) offer a new opportunity to develop luminescent host–guest materials. Two linear π‐conjugated fluorescent molecules, 1,4‐bis‐p‐cyanostyrylbenzene (bpcb) and 1,4‐bis(5‐phenyloxazol‐2‐yl)benzene (bpob), incorporated into MOF‐5 systems are reported. The as‐obtained bpcb@MOF‐5 and bpob@MOF‐5 displayed tunable blue fluorescent properties (emission wavelength, fluorescent lifetime, and quantum yield) compared with the pure guest molecule and host matrix. Moreover, bpcb@MOF‐5 and bpob@MOF‐5 thin films were fabricated by the solvent‐evaporation method. The MOF‐based thin films exhibit well‐defined polarized blue emission with a fluorescent anisotropy of approximately 0.15, demonstrating the uniform dispersion and well‐oriented bpcb and bpob chromophores within the MOF matrix. Furthermore, a periodic density functional theoretical (DFT) calculation demonstrates that the photoactive molecule assembled MOFs systems feature energy and/or electron transfer between the guest and host framework during the photoexcitation process, thus suggesting that the encapsulated molecule can further modify the electronic structure of the host MOF materials. Based on the combination of experimental and theoretical studies on the fluorescent guests@MOF systems, this study not only presents a feasible method for fabricating MOF‐based powders and films with tunable luminescence, but also gives detailed information on the geometric and electronic structures of the photoactive molecule confined within the MOF matrix.
Peroxometalates Immobilized on Magnetically Recoverable Catalysts for Epoxidation
Authors: Qiao Yunxiang , Li Huan , Hua Li , Orzechowski Lars , Yan Kai , Feng Bo , Pan Zhenyan , Theyssen Nils , Leitner Walter , Hou Zhenshan 
Published: October 2012

AbstractMagnetically separable catalysts were prepared and employed for the epoxidation of olefins with hydrogen peroxide. In all cases the magnetic core was firstly covered with a silica layer to prevent iron ion‐initiated decomposition of hydrogen peroxide. The catalytic active species, an ionic liquid‐type peroxotungstate, was then immobilized either by hydrogen bonding (catalyst 1) or by covalent SiO linkage (catalyst 2). In addition to a thorough characterization by FT‐IR, XRD, NMR, DRIFT, XPS, and TEM, the catalytic potential was evaluated in the epoxidation of a variety of olefins as well as allylic alcohols. Both catalysts showed essentially a constant activity after at least ten consecutive cycles. On the basis of the research above, a new type of magnetically separable catalyst was constructed by immobilization of lacunary‐type phosphotungstate by hydrogen bonding between the sulfonate anion and silanol group on the surface of the core–shell magnetic nanoparticles. After the detailed characterization, the catalyst was used in the epoxidation of a variety of olefins and allylic alcohols and was found to possess high activity, selectivity towards epoxides, and a constant activity after at least ten catalytic recycles without solvent.
Measuring bluff erosion part 2: pairing aerial photographs and terrestrial laser scanning to create a watershed scale sediment budget
Authors: Day Stephanie S. , Gran Karen B. , Belmont Patrick , Wawrzyniec Tim 
Published: October 2012

ABSTRACTEffectively managing and reducing high suspended sediment loads in rivers requires an understanding of the magnitude of major sediment sources as well as erosion and transport processes that deliver excess fine sediments to the channel network. The focus of this research is to determine the magnitude of erosion from tall bluffs, a primary sediment source in the 2880 km2 Le Sueur watershed, Minnesota, USA. We coupled analyses of seven decades of aerial photographs with four years of repeat terrestrial laser scanning (TLS) to determine erosion rates on bluffs. Together, these datasets provide decadal‐scale retreat rates throughout the entire watershed and high‐resolution geomorphic change detection on a subset of bluffs to both constrain erosion rates and document how environmental conditions affect bluff retreat. Erosion rates from aerial photographs and TLS were extrapolated from 243 and 15 measured bluffs, respectively, to all 480 bluffs in the Le Sueur watershed using multiple techniques to obtain estimates of sediment loading from these features at the watershed‐scale. Despite different spatial and temporal measurement scales, the aerial photograph and TLS estimates yielded similar results for bluff retreat rate and total mass of sediment derived from bluffs, with bluffs in the Le Sueur watershed yielding 135 000 ± 39 000 Mg/yr of fine sediment. Comparing this value to the average annual total suspended solids (TSS) load determined from gauging from 2000 to 2010, we determined that bluffs comprise 57 ± 16% of the total TSS load, making bluffs the single most abundant fine sediment source in the basin. Copyright © 2012 John Wiley & Sons, Ltd.