bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Arterial Rigidity with Incident Kidney Disease and Kidney Function Decline
Authors: Madero Magdalena , Peralta Carmen , Katz Ronit , Canada Robert , Fried Linda , Najjar Samer , Shlipak Michael , Simonsick Eleanor , Lakatta Edward , Patel Kushang , Rifkin Dena , Hawkins Marquis , Newman Anne , Sarnak Mark 
Published: December 2012

Summary

Background and objective
The association of large arterial rigidity and kidney function decline in longitudinal analyses is not well established. This study evaluated the association of aortic pulse wave velocity (aPWV) and pulse pressure (PP) with rapid kidney function decline and incident CKD in the Health, Aging and Body Composition study.

Design, setting, participants, & measurements
Participants were 2129 older adults with a baseline measurement of aPWV, PP, and cystatin C and at least one additional measurement of cystatin C, either at year 3 or year 10. Outcomes were rapid kidney function decline (estimated GFRcysC loss of >3 ml/min per 1.73 m2 per year) and incident CKD (eGFRcysC < 60 ml/min per 1.73 m2 in participants with baseline estimated GFR > 60 ml/min per 1.73 m2). Multivariate regression models were used to evaluate association of aPWV and PP with each outcome.

Results
Mean (SD) baseline estimated GFRcysC was 79±29 ml/min per 1.73 m2. Median follow-up duration was 8.9 years. In multivariable analyses, aPWV was not associated with rapid decline (odds ratio [OR], 95% confidence interval [CI] 1.16, 0.89–1.52) but was associated with incident CKD (incident rate ratio [IRR], 95% CI, 1.39, 1.09–1.77) and PP was associated with both rapid decline (OR, 95% CI 1.10, 1.04–1.16) and incident CKD (IRR, 95% CI, 1.06, 1.01–1.11).

Conclusions
Large arterial stiffness assessed by aPWV and pulsatility assessed by PP were associated with incident CKD among older adults. Pulsatility assessed by PP was associated with rapid kidney function decline and incident CKD. Future research should determine whether interventions targeting arterial rigidity will prevent CKD development and progression.
Evaluation of matrix metalloproteinase-2 and -9 in the cerebrospinal fluid of dogs with intracranial tumors
Authors: Mariani Christopher L. , Boozer Lindsay B. , Braxton Alicia M. , Platt Simon R. , Vernau Karen M. , McDonnell John J. , Guevar Julien 
Published: December 2012

Abstract
Objective—To identify matrix metalloproteinase (MMP)-2 and -9 in CSF from dogs with intracranial tumors.
Sample—CSF from 55 dogs with intracranial tumors and 37 control dogs.
Procedures—Latent and active MMP-2 and -9 were identified by use of gelatin zymography. The presence of MMPs in the CSF of dogs with intracranial tumors was compared with control dogs that were clinically normal and with dogs that had idiopathic or cryptogenic epilepsy or peripheral vestibular disease. Relationships between MMP-9 and CSF cell counts and protein were also investigated.
Results—Latent MMP-2 was found in CSF samples from all dogs, although active MMP-2 was not detected in any sample. Latent MMP-9 was detected in a subset of dogs with histologically documented intracranial tumors, including meningiomas (2/10), gliomas (3/10), pituitary tumors (1/2), choroid plexus tumors (5/6), and lymphoma (4/4), but was not detected in any control samples. Dogs with tumors were significantly more likely than those without to have detectable MMP-9 in the CSF, and the presence of MMP-9 was associated with higher CSF nucleated cell counts and protein concentration.
Conclusions and Clinical Relevance—Latent MMP-9 was detected in most dogs with choroid plexus tumors or lymphoma but in a smaller percentage of dogs with meningiomas, gliomas, or pituitary tumors. Detection of MMP in CSF may prove useful as a marker of intracranial neoplasia or possibly to monitor response of tumors to therapeutic intervention.
Effects of interstitial cystitis on the acoustic startle reflex in cats
Authors: Hague Devon W. , Stella Judi L. , Buffington C. A. Tony 
Published: December 2012

Abstract
Objective—To compare acoustic startle reflexes (ASRs) of healthy cats and cats with interstitial cystitis (IC).
Animals—28 healthy cats (11 males and 17 females) and 20 cats with IC (13 males and 7 females).
Procedures—To evaluate the effect of neutering on ASRs, ASRs in neutered and unneutered healthy cats were measured. To evaluate the effect of housing facility acclimation on ASRs in cats with IC, ASRs were measured in cats with IC within 1 month after arrival at the housing facility and again 2 to 3 months after arrival. To evaluate the effect of the environment on ASRs, ASRs were evaluated in all cats with and without IC after acclimation but before and then after environmental enrichment.
Results—Neutering led to a significant decrease in overall ASR in the healthy cats. Habituation to the housing facility resulted in a significant decrease in overall ASR of female but not male cats with IC. Environmental enrichment led to a significant decrease in ASR in cats with IC but not in healthy cats.
Conclusions and Clinical Relevance—The magnitude of the ASR appeared to be sensitive to environmental conditions and affected by sex, both in healthy cats and cats with IC. It was also higher in cats with IC versus healthy cats, except when cats were housed in a highly enriched environment.
Impact for Human Medicine—Treatment approaches that include reduction of a patient's perception of environmental unpredictability may benefit humans with IC.
Comparison of a body-mounted inertial sensor system–based method with subjective evaluation for detection of lameness in horses
Authors: Keegan Kevin G. , Wilson David A. , Kramer Joanne , Reed Shannon K. , Yonezawa Yoshiharu , Maki Hiromitchi , Pai P. Frank , Lopes Marco A. F. 
Published: December 2012

Abstract
Objective—To compare data obtained with an inertial sensor system with results of subjective lameness examinations performed by 3 experienced equine veterinarians for evaluation of lameness in horses.
Animals—106 horses.
Procedures—Horses were evaluated for lameness with a body-mounted inertial sensor system during trotting in a straight line and via subjective evaluation by 3 experienced equine practitioners who performed complete lameness examinations including lunging in a circle and limb flexion tests. Agreement among evaluators regarding results of subjective evaluations and correlations and agreements between various inertial sensor measures and results of subjective lameness evaluations were determined via calculation of Fleiss’ κ statistic, regression analysis, and calculation of 95% prediction intervals.
Results—Evaluators agreed on classification of horses into 3 mutually exclusive lameness categories (right limb lameness severity greater than left limb lameness severity, left limb lameness severity greater than right limb lameness severity, or equal right and left limb lameness severity) for 58.8% (κ = 0.37) and 54.7% (κ = 0.31) of horses for forelimb and hind limb lameness, respectively. All inertial sensor measures for forelimb and hind limb lameness were positively and significantly correlated with results of subjective evaluations. Agreement between inertial sensors measures and results of subjective evaluations was fair to moderate for forelimb lameness and slight to fair for hind limb lameness.
Conclusions and Clinical Relevance—Results of lameness evaluation of horses with an inertial sensor system and via subjective lameness examinations were significantly correlated but did not have strong agreement. Inertial sensor-based evaluation may augment but not replace subjective lameness examination of horses.
Development of FeOOH nanoarrays using magnetic cations
Authors: Garcia-Casillas Perla , Martinez-Pérez Carlos , González Claudia , Camacho-Montes Héctor , Martel Estrada Santos , Armendáriz Imelda 
Published: December 2012

Abstract
Abstract In this work, FeOOH arrays were obtained using two different magnetic cations. The nanoparticles were grouped into a package having different orientations through the van der Waals interaction with the magnetic cations. With Fe2+, the FeOOH nanoparticles have a rod shape with a 30-nm diameter and approximately 1-micron length, and are aligned in a star structure. With Co2+, a somatoidal shape was observed, with 20-nm diameter and 150-nm length and a pathway structure to the array. The chemical synthesis method was used to obtain the nanoarrays. The morphology and the average size of the nanorods and nanowires were determined using Field Emission Scanning Electron Microscopy (FESEM). Fourier Transform Infrared Spectroscopy (FTIR) was used to study the interaction between the nanorods and the cobalt ions. The phases of the material were identified using X-ray Diffraction. Graphical abstract
Differentiation of mesenchymal stem cells derived from human bone marrow and subcutaneous adipose tissue into pancreatic islet-like clusters in vitro
Authors: Marappagounder Dhanasekaran , Somasundaram Indumathi , Dorairaj Sudarsanam , Sankaran Rajkumar 
Published: December 2012

AbstractAlthough stem cells are present in various adult tissues and body fluids, bone marrow has been the most popular source of stem cells for treatment of a wide range of diseases. Recent results for stem cells from adipose tissue have put it in a position to compete for being the leading therapeutic source. The major advantage of these stem cells over their counterparts is their amazing proliferative and differentiation potency. However, their pancreatic lineage transdifferentiation competence was not compared to that for bone marrow-derived stem cells. This study aims to identify an efficient source for transdifferentiation into pancreatic islet-like clusters, which would increase potential application in curative diabetic therapy. The results reveal that mesenchymal stem cells (MSC) derived from bone marrow and subcutaneous adipose tissue can differentiate into pancreatic islet-like clusters, as evidenced by their islet-like morphology, positive dithizone staining and expression of genes such as Nestin, PDX1, Isl 1, Ngn 3, Pax 4 and Insulin. The pancreatic lineage differentiation was further corroborated by positive results in the glucose challenge assay. However, the results indicate that bone marrow-derived MSCs are superior to those from subcutaneous adipose tissue in terms of differentiation into pancreatic islet-like clusters. In conclusion, bone marrow-derived MSC might serve as a better alternative in the treatment of diabetes mellitus than those from adipose tissue.
Application of Hurwitz-Radon matrices in curve interpolation and almost-smoothing
Authors: Jakóbczak Dariusz 
Published: December 2012

AbstractDedicated methods for dealing with curve interpolation and curve smoothing have been developed. One such method, Hurwitz-Radon Matrices (MHR), can be used in reconstruction and interpolation of curves in the plane. The method is based on a family of Hurwitz-Radon (HR) matrices. The matrices are skew-symmetric and possess columns composed of orthogonal vectors. The of Hurwitz-Radon Operator (OHR), built from these matrices, is described. It is shown how to create the orthogonal and discrete OHR and how to use it in a process of curve interpolation and modelling. The method needs suitable choice of nodes, i.e. points of the curve to be reconstructed: nodes should be settled at each local extremum and nodes should be monotonic in one of coordinates (for example equidistance). Application of MHR gives a very good interpolation accuracy in the process of modeling and reconstruction of the curve. Created from the family of N-1 HR matrices and completed with the identity matrix, the system of matrices is orthogonal only for vector spaces of dimensions N = 2, 4 or 8. Orthogonality of columns and rows is very important and significant for stability and high precision of calculations. The MHR method models the curve point by point without using any formula or function. Main features of the MHR method are: the accuracy of curve reconstruction depends on the number of nodes and method of choosing nodes, interpolation of L points of the curve has a computational cost of rank O(L), and the smoothing of the curve depends on the number of OHR operators used to build the average matrix operator. The problem of curve length estimation is also considered. Algorithms and numerical results are presented.
DRL-Prefixspan: A novel pattern growth algorithm for discovering downturn, revision and launch (DRL) sequential patterns
Authors: George Aloysius , Binu D. 
Published: December 2012

AbstractDiscovering sequential patterns is a rather well-studied area in data mining and has been found many diverse applications, such as basket analysis, telecommunications, etc. In this article, we propose an efficient algorithm that incorporates constraints and promotion-based marketing scenarios for the mining of valuable sequential patterns. Incorporating specific constraints into the sequential mining process has enabled the discovery of more user-centered patterns. We move one step ahead and integrate three significant marketing scenarios for mining promotion-oriented sequential patterns. The promotion-based market scenarios considered in the proposed research are 1) product Downturn, 2) product Revision and 3) product Launch (DRL). Each of these scenarios is characterized by distinct item and adjacency constraints. We have developed a novel DRL-PrefixSpan algorithm (tailored form of the PrefixSpan) for mining all length DRL patterns. The proposed algorithm has been validated on synthetic sequential databases. The experimental results demonstrate the effectiveness of incorporating the promotion-based marketing scenarios in the sequential pattern mining process.
Word sense disambiguation to improve precision for ambiguous queries
Authors: Chifu Adrian-Gabriel , Ionescu Radu-Tudor 
Published: December 2012

AbstractSuccess in Information Retrieval (IR) depends on many variables. Several interdisciplinary approaches try to improve the quality of the results obtained by an IR system. In this paper we propose a new way of using word sense disambiguation (WSD) in IR. The method we develop is based on Naïve Bayes classification and can be used both as a filtering and as a re-ranking technique. We show on the TREC ad-hoc collection that WSD is useful in the case of queries which are difficult due to sense ambiguity. Our interest regards improving the precision after 5, 10 and 30 retrieved documents (P@5, P@10, P@30), respectively, for such lowest precision queries.
Book Reviews
Authors: Stan Sabina , Murphy Fiona 
Published: December 2012

Esin Bozkurt (2009), Conceptualising 'Home': The Question of Belonging Among Turkish Families in Germany (Frankfurt/M. and New York: Campus), 243 pp., Pb: €32.90, ISBN: 978-3593387918.Brigitte Bönisch-Brednich and Catherine Trundle (eds) (2010), Local Lives: Migration and the Politics of Place (Aldershot: Ashgate), 218 pp., Hb: £55.00, ISBN: 978-1-4094-0103-2.
Internationalization among emerging countries: insights from Brazilian-Russian beef network
Authors: Thomé Karim Marini , Vieira Luciana Marques 
Published: December 2012

Abstract
This paper examines the expansion (or internationalization) of Brazilian firms into the Russian market, by applying the revised model of Uppsala in the context of emerging economies. The study is an exploratory descriptive study based on case studies of four Brazilian meatpackers with operations in Russia. The results show that the revised model of Uppsala partially explains the internationalization of the firms studied. Some evidence regarding the influence of the business network was empirically found. However, some concepts proposed by the revised model, such as the manner in which a network limits company expansion, were not found. This study contributes empirical evidence to support the theoretical framework and opens avenues for further research on business networks among emerging countries.
Managing Russian agri-food supply chain networks with power
Authors: Belaya Vera , Hanf Jon Henrich 
Published: December 2012

Abstract
The importance of power is underlined by many scientists who view it as a key behavioural construct. Power distinguishes itself as an effective tool in coordinating and promoting harmonious relationships, solving conflicts, and enhancing performance. An important challenge is to find out what role power plays in managing supply chain networks, paying specific attention to its effects on coordination and cooperation. The aim of our work is to investigate the role of power in supply chain networks in order to work out a strategy that enables supply chain managers to select an effective mix of power mechanisms. We critically examine the existing literature and elaborate on the role of power in supply chain relationships. We work out and test a theoretical model of the effects of power on cooperation and coordination and discuss possible managerial implications of using power as an effective tool for promoting supply chain management. To verify our research hypotheses we conducted semi-structured in-depth expert interviews via telephone about relationships of international food processing companies with their suppliers in Russia and tested the model using the Partial Least Squares (PLS) approach. Depending on the origin of power, it may have different effects on cooperation and coordination. Based on the results of the survey we worked out a special ranking system for the use of power depending on its expected effect on coordination and cooperation. Expert power has the highest ranking among the other types of power for improving coordination. Therefore, we recommend using this strategy as a first priority for improving coordination. The data in our PLS analysis represent only a single perspective in the dyad: food processing companies. Gathering data from other companies’ perspectives, such as retailers or agricultural producers, could have produced different (presumably more realistic or complete) findings. Our study offers recommendations for managers about the use of different types of power in managing the Russian agri-food supply chains, with specific attention paid to coordination and cooperation issues. In order to manage supply chain networks successfully, knowledge of different types of power is essential. The developed ranking of different types of power according to their effects on coordination and cooperation is designed to help managers make the right decisions in choosing the appropriate type of power for coordination purposes.
Review of Most Important Biomedical Databases for Searching of Biomedical Scientific Literature
Authors: Masic Izet , Ferhatovica Asima 
Published: December 2012

ABSTRACT
We are living in the time of displossion of medical scientific information. Only in PubMed/MedLine, one of the largest host of scientific biomedical literature is indexed in almost 5,000 scientific biomedical journals. Each scientific paper is recorded in data written by rules recommended by several scientific associations and institutions. Databases can contain information about the author(s) and his/their published scientific works or results of research/investigation, including bibliographic data, abstract or full text of the paper. The databases are collecting and processing the best scientific and professional papers, or reviews and case reports published in scientific and professional journals or other publications. The reliability and quality of information guarantees producers of databases. Most important databases are located in famous university/academic centers like Bethesda [National Library Medicine (NLM)], Philadelphia (ISI), Amsterdam (Elsevier), Ipswitch (EBSCO), Geneva (WHO), Moscow (RAS), Shiraz [Islamic World Science Citation Center (ISC)], Warsaw [Index Copernicus (IC)]. Author of this review article shortly described most important online databases of biomedical literature today which will be usefull for scientists or other medical professionals.

How to cite this article
Masic I. Review of Most Important Biomedical Databases for Searching of Biomedical Scientific Literature. Donald School J Ultrasound Obstet Gynecol 2012;6(4):343-361.
Three-dimensional/Four-dimensional Sonography moved Prenatal Diagnosis of Fetal Anomalies from the Second to the First Trimester of Pregnancy
Authors: Pooh Ritsuko K 
Published: December 2012

ABSTRACT
The introduction of three-dimensional (3D)/four-dimensional (4D) sonography with high-frequency transvaginal transducer has resulted in remarkable progress in ultrasonographic visualization of early embryos and fetuses and development of new fields of 3D sonoembryology. With the proper use of this new diagnostic modality and with experienced examiner, both structural and functional development in the first trimester of gestation can be assessed more objectively and reliable.
Indeed, new technology moved embryology from postmortem studies to the in vivo environment. Furthermore, there are good reasons to believe that 3D/4D sonography moved prenatal diagnosis of fetal abnormalities from the second to the first trimester of pregnancy. We will try to illustrate it with the number of convincing figures.

How to cite this article
Pooh RK, Kurjak A. Three-dimensional/ Four-dimensional Sonography moved Prenatal Diagnosis of Fetal Anomalies from the Second to the First Trimester of Pregnancy. Donald School J Ultrasound Obstet Gynecol 2012;6(4):376-390.
EZH2 Is Required for Breast and Pancreatic Cancer Stem Cell Maintenance and Can Be Used as a Functional Cancer Stem Cell Reporter
Authors: van Vlerken Lilian E. , Kiefer Christine M. , Morehouse Chris , Li Ying , Groves Chris , Wilson Susan D. , Yao Yihong , Hollingsworth Robert E. , Hurt Elaine M. 
Published: December 2012

Abstract
Although cancer is largely seen as a disease stemming from genetic mutations, evidence has implicated epigenetic regulation of gene expression as a driving force for tumorigenesis. Epigenetic regulation by histone modification, specifically through polycomb group (PcG) proteins such as EZH2 and BMI-1, is a major driver in stem cell biology and is found to be correlated with poor prognosis in many tumor types. This suggests a role for PcG proteins in cancer stem cells (CSCs). We hypothesized that epigenetic modification by EZH2, specifically, helps maintain the CSC phenotype and that in turn this epigenetic modifier can be used as a reporter for CSC activity in an in vitro high-throughput screening assay. CSCs isolated from pancreatic and breast cancer lines had elevated EZH2 levels over non-CSCs. Moreover, EZH2 knockdown by RNA interference significantly reduced the frequency of CSCs in all models tested, confirming the role of EZH2 in maintenance of the CSC population. Interestingly, genes affected by EZH2 loss, and therefore CSC loss, were inversely correlated with genes identified by CSC enrichment, further supporting the function of EZH2 CSC regulation. We translated these results into a novel assay whereby elevated EZH2 staining was used as a reporter for CSCs. Data confirmed that this assay could effectively measure changes, both inhibition and enrichment, in the CSC population, providing a novel approach to look at CSC activity. This assay provides a unique, rapid way to facilitate CSC screening across several tumor types to aid in further CSC-related research.