bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disposition of ampicillin trihydrate in plasma, uterine tissue, lochial fluid, and milk of postpartum dairy cattle
Authors: Credille B. C. , Giguère S. , Vickroy T. W. , Fishman H. J. , Jones A. L. , Mason M. E. , DiPietro R. O. , Ensley D. T. 
Published: November 2014

The objective of this study was to determine the disposition of ampicillin in plasma, uterine tissue, lochial fluid, and milk of postpartum dairy cattle. Ampicillin trihydrate was administered by intramuscular (i.m.) injection at a dose of 11 mg/kg of body weight every 24 h (n = 6, total of 3 doses) or every 12 h (n = 6, total of 5 doses) for 3 days. Concentrations of ampicillin were measured in plasma, uterine tissue, lochial fluid, and milk using HPLC with ultraviolet absorption. Quantifiable ampicillin concentrations were found in plasma, milk, and lochial fluid of all cattle within 30 min, 4 h, and 4 h of administration of ampicillin trihydrate, respectively. There was no significant effect of dosing interval (every 12 vs. every 24 h) and no significant interactions between dosing interval and sampling site on the pharmacokinetic variable measured or calculated. Median peak ampicillin concentration at steady‐state was significantly higher in lochial fluid (5.27 μg/mL after q 24 h dosing) than other body fluids or tissues and significantly higher in plasma (3.11 μg/mL) compared to milk (0.49 μg/mL) or endometrial tissue (1.55 μg/mL). Ampicillin trihydrate administered once daily by the i.m. route at the label dose of 11 mg/kg of body weight achieves therapeutic concentrations in the milk, lochial fluid, and endometrial tissue of healthy postpartum dairy cattle.
Control of hypertension and survival in haemodialysis patients
Authors: Iseki Kunitoshi 
Published: November 2014

AbstractHypertension is common in approximately 80% to 90% of patients at the start of dialysis therapy and is an established risk factor for cardiovascular disease. Therefore, it should be controlled, even in the chronic dialysis population. Observational studies indicate a U‐shaped phenomenon, as the mortality rate is high among those with hypertension as well as those with hypotension. Among chronic dialysis patients, randomized controlled trials on the effect of anti‐hypertensive treatment are not conclusive, at least not as demonstrated by studies with a large sample size. Similar to other potentially effective drug therapies such as erythropoietin stimulating agent, statins, and uraemic toxin adsorbents, the benefit of anti‐hypertensive treatment remains to be demonstrated in dialysis patients. The blood pressure target level, however, is difficult to determine as evidence for the level of appropriate target is lacking. Currently, it should be determined individually, as the priority is to perform haemodialysis as prescribed. The target levels of blood pressure for chronic haemodialysis patients are not stated except in the Guidelines in the Japanese Society for Dialysis Therapy. In this guideline, systolic blood pressure between 140 to 159 mmHg is preferable among elderly patients with comorbid conditions. Rapid ultrafiltration, such as >600 mL/h, is to be avoided. Intra‐dialysis hypotension, muscle cramps, and other complaints during HD are preventable. Moreover, the nutritional status should be maintained within the normal range with adequate intake of protein and calories, but with salt restriction. Further studies are necessary for better management of hypertension in the dialysis population.
Optimal duration of allergen immunotherapy in children with dust mite respiratory allergy
Authors: Arroabarren Esozia , Tabar Ana I. , Echechipía Susana , Cambra Koldo , García Blanca E. , Alvarez‐Puebla Maria J. 
Published: November 2014

AbstractBackgroundSubcutaneous immunotherapy (SCIT) discontinuation data in children remain scarce.ObjectiveWe sought for differences in the clinical efficacy of 3 vs. 5 yr of SCIT in children with dust mite respiratory allergy.MethodsWe performed a 5‐yr, phase IV prospective study. After the first year, the patients were randomized to 3 (IT3) or 5 yr of treatment (IT5). Efficacy was assessed at 3rd and 5th year by symptom and medication scores and visual analog scales (VAS). Skin tests with common allergens and in vitro assessments were also performed.ResultsEighty‐one children (mean age: 9 yr) were randomly assigned to 3 (IT3: 41) or 5 yr (IT5: 40) of immunotherapy. After 3 years, rhinitis global scores decreased in IT3 (44%; p = 0.002) and in IT5 (50%; p = 0.001). Asthma global, symptom and medication scores decreased by 100% in IT3 (p = 0.001) and IT5 (p = 0.001). VAS scores also diminished significantly (IT3: 70%, p = 0.001; IT5: 62.5%; p = 0.001). At 5th year, global rhinitis scores were reduced an additional 30% in IT5 children. Comparisons between both groups did not show differences in rhinitis (p = 0.055), asthma global scores (p = 0.948) or VAS scores at 5th year. Twenty percent of IT5 (p = 0.002) and 7% of IT3 children (p = 0.705) developed new sensitizations. At 5th year, sIgG4 determinations decreased in IT3 without significant variations in IT5.ConclusionsThree years of SCIT induced significant improvement in children with dust mite respiratory allergy, but a 5‐yr course added clinical improvement in rhinitis.
Toxoplasma gondii‐induced neuronal alterations
Authors: Parlog A. , Schlüter D. , Dunay I. R. 
Published: November 2014

SummaryThe zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The intracellular parasite can persist lifelong in the CNS within neurons modifying their function and structure, thus leading to specific behavioural changes of the host. In recent years, several in vitro studies and murine models have focused on the elucidation of these modifications. Furthermore, investigations of the human population have correlated Toxoplasma seropositivity with changes in neurological functions; however, the complex underlying mechanisms of the subtle behavioural alteration are still not fully understood. The parasites are able to induce direct modifications in the infected cells, for example by altering dopamine metabolism, by functionally silencing neurons as well as by hindering apoptosis. Moreover, indirect effects of the peripheral immune system and alterations of the immune status of the CNS, observed during chronic infection, might also contribute to changes in neuronal connectivity and synaptic plasticity. In this review, we will provide an overview and highlight recent advances, which describe changes in the neuronal function and morphology upon T. gondii infection.
EP217609, a neutralisable dual-action FIIa/FXa anticoagulant, with antithrombotic effects in arterial thrombosis
Authors: Alame Ghina , Mangin Pierre H. , Freund Monique , Riehl Nadia , Magnenat Stéphanie , Petitou Maurice , Hechler Béatrice , Gachet Christian 
Published: November 2014

SummaryEP217609 is a new synthetic parenteral dual-action anticoagulant combining a direct thrombin inhibitor (α-NAPAP analog), an indirect factor Xa inhibitor (fondaparinux analog) and a biotin moiety allowing its neutralisation. EP217609 exhibited similar in vitro anticoagulant properties as its parent compounds. On the basis of dose-response curves, we identified low and moderate doses of EP217609 resulting in similar ex vivo prolongation of the APTT as α-NAPAP analog and comparable ex vivo anti-FXa activity as fondaparinux. The effects of EP217609 were compared to those of its parent compounds used alone or in combination in two models of experimental thrombosis induced by FeCl3 injury of the carotid artery or mechanical injury of atherosclerotic plaques in ApoE-deficient mice. When administered at low doses increasing the APTT by only 1.1 fold, EP217609 significantly reduced the thrombus area in both models as compared to α-NAPAP analog or fondaparinux alone, but not to the combination of these drugs. In contrast, at higher doses increasing the APTT 1.5 times, EP217609 was not superior to either parent compound. Low doses of EP217609 did not prolong the tail bleeding time or increase the volume of blood loss, although a tendency towards an increased blood loss was observed in five out of 12 mice. Finally, the effects of EP217609 could be neutralised in vivo by injection of avidin. The pharmacological profile of EP217609, its performance in arterial thrombosis models and its possible neutralisation make it an interesting molecule and a potential candidate as an antithrombotic drug.
First report of intersex in the signal crayfish Pacifastacus leniusculus (Dana, 1852)
Authors: Yazicioglu B. , Yazicioglu B. , Linhartova Z. , Yazicioglu B. , Linhartova Z. , Niksirat H. , Yazicioglu B. , Linhartova Z. , Niksirat H. , Kozak P. 
Published: November 2014

The reproductive strategies of species of non-indigenous crayfish make an important issue in astacological research. Although crayfish reproduction has been well studied, there is little information available on the occurrence of intersexuality. We report the first evidence of intersex in the signal crayfish, Pacifastacus leniusculus (Dana, 1852). An intersexual specimen was found among five tested signal crayfish. Morphology revealed both male and female genital openings, as well as male gonopods. The specimen superficially appeared male but contained both testes and ovaries, with an atypical dispersed structure. Sperm was obtained from this crayfish. Histology showed both spermatocytes and oocytes. The gonadosomatic index (GSI = 3.79) was considered as a morphometric parameter of the intersexual crayfish. The ova present in the intersex male raised its GSI to the three-fold of that of normal males.
Recent trends on the stent research for blood arteries by bibliometric analysis
Authors: Ahn Sejung , Sung Jung-Suk , Choi Brad , Kim Hackjoo , Sung Yong Kiel 
Published: November 2014

Abstract
The research trends on stent for blood arteries are reviewed by bibliometric analysis using 7,790 journal articles published from 1986 to 2013 of the Web of Science database. The bibliometric indicators are applied to analyze the journal article data, which are simple number of publications for selecting key players, citation indicators for measuring qualitative research performance, collaboration indicators for figuring out the degree of international collaboration and keyword mapping for identifying the research trends. The studies of stent for blood arteries are investigated on the basis of the analysis by countries, institutions and topic changing. The leading countries and institutions published many high-quality journal articles with strong international collaboration. In this report, the current status and future of research trends are clearly revealed from the periodic topic changing analysis. The keywords such as ‘drug eluting stent’, ‘stent coated with new polymers’ and ‘drug delivery systems’ have come into the recent stent-related research, which means lots of efforts are under way to overcome the present limitations of the research.
Chemistry of Anthracene–Acetylene Oligomers. XXIV. Theoretical Evaluation of Molecular Strain and Interactions in Anthracene–Acetylene Cyclic Oligomers by Homodesmotic Reaction Method
Authors: Toyota Shinji , Wakamatsu Kan , Kawakami Takahiro , Iwanaga Tetsuo 
Published: November 2014

Abstract
The structures and stabilities of 1,8-anthrylene cyclic oligomers having acetylene or diacetylene linkers were investigated by DFT calculations with M05 and M06 series functionals. The structures of the cyclic oligomers were reasonably reproduced at the M05-2X/6-31G* level by using the interlayer distance between stacking anthracene planes in the anthracene–acetylene cyclic tetramer as benchmark. The structural features of the cyclic oligomers ranging from dimers to hexamers were discussed on the basis of the optimized structures. The stabilities of the cyclic oligomers were analyzed by thermochemical calculations of the homodesmotic reactions. The decreased stabilities of the odd-numbered oligomers are mainly attributable to molecular strain due to bending deformations at acetylene carbons. The increased stabilities of the tetramers and the hexamers are attributable to the intramolecular π···π interactions between anthracene units. The contributions of other factors influencing the overall stability, such as conjugation, steric hindrance, aromaticity, and CH···π interaction, are also discussed.
The Impact of Corporate Sustainability on Organizational Processes and Performance
Authors: Eccles Robert G. , Ioannou Ioannis , Serafeim George 
Published: November 2014

We investigate the effect of corporate sustainability on organizational processes and performance. Using a matched sample of 180 U.S. companies, we find that corporations that voluntarily adopted sustainability policies by 1993—termed as high sustainability companies—exhibit by 2009 distinct organizational processes compared to a matched sample of companies that adopted almost none of these policies—termed as low sustainability companies. The boards of directors of high sustainability companies are more likely to be formally responsible for sustainability, and top executive compensation incentives are more likely to be a function of sustainability metrics. High sustainability companies are more likely to have established processes for stakeholder engagement, to be more long-term oriented, and to exhibit higher measurement and disclosure of nonfinancial information. Finally, high sustainability companies significantly outperform their counterparts over the long term, both in terms of stock market and accounting performance.This paper was accepted by Bruno Cassiman, business strategy.
Investigations on Prevalence and Antimicrobial Resistance of Enterohaemorrhagic Escherichia Coli (Ehec) Among Dairy Farms in the North Part of the Republic of Bulgaria
Authors: Urumova Valentina , Lyutzkanov Mihni , Petrov Vladimir 
Published: November 2014

Abstract
Over a 2-year period, from January 2011 to May 2013, a total of 1094 faecal swab samples were collected from cattle at different age at 4 farms in North Bulgaria: Okorsh, Slavyanovo (Popovo municipality), Dobri dol and Trem. Out of them, 36 coli strains (3.3%) positive in the E. coli O:157 antiserum agglutination test and identified by the BBL CRYSTAL identification system as belonging to the E. coli O:157 serotype were isolated. The distribution of isolates was as followed: 5 (0.5%) E. coli O:157 strains at the Okorsh dairy cattle farm, 7 (0.6%) E. coli isolates at the Slavyanovo dairy farm, 16 (1.5%) isolates at the Dobri dol farm and 8 (0.7%) isolates at the Trem farm. Colibacteria exhibited 100% sensitivity to oxyimino-cephalosporins, gentamicin and enrofloxacin, and were resistant to ampicillin (19.4%) and tetracycline (41.6%). From the 15 strains resistant to tetracycline, 11 were isolated from the cows at Dobri dol, while the other 4 originated from the other three farms. The 7 ampicillin-resistant E. coli isolates were detected only at the Dobri dol cattle farm.
L’attachement à soi face aux fins morales: une question stoïcienne
Authors: Kühn Wilfried 
Published: November 2014

Abstract:According to current interpretation of their ethics the Stoics incorporated in the theory of happiness the conception of attachment to oneself (οἰκείωσις πρὸς ἑαυτόν) supposed to be changed into attachment to reason. This article aims to show that there is no textual evidence to corroborate this idea, and that, on the contrary, several texts and conceptual configurations tell against it. The same seems to hold true for the life of human adults who are not wise and keep their animal attachment to themselves (Hierocles): as Cicero apparently suspected, the moral maxim of this life, i.e. self-preservation
Measuring Self-Service Technology Latent Difficulties: Insurance Decisions on Utilitarian and Hedonic Influences
Authors: Yang Ann Shawing 
Published: November 2014

Abstract
This study investigates the difficulties encountered by consumers in forming insurance decisions when using self-service technology (SST) channels, such as electronic insurance. Rasch measurement model is applied. This model employs the expectation disconfirmation theory to categorize and rank the order of importance of latent utilitarian and hedonic insurance purchase motives. Consumers find that electronic insurance has high risks and high premiums with respect to utilitarian motives but lacks information and performs unsatisfactorily in terms of hedonic motives. Nevertheless, electronic insurance is preferred for the convenience brought by SST channels, and because it provides greater discounts and offers product–channel matching through self-consultation in the absence of agents. Being middle-aged and having a high income are factors that significantly influence electronic insurance purchases.
A Contrastive Perspective on the Appraisal Strategies of English Writing of Chinese and Western Reviewers
Authors: Xu Yusu 
Published: November 2014

AbstractUnder the guidance of Contrastive Rhetoric, this paper applies the attitudinal system of Appraisal Theory in the comparative study of the appraisal strategies between Chinese and Western literary reviews. Analysis of 12 English literary reviews by native speakers of both cultures reveals that they exert strategic differences. First, the Chinese reviews employ fewer appraisal resources than their Western counterparts. Second, they differ in their preference for the patterning of the three attitudinal sub-systems (Affect, Judgment, Appreciation). This study discloses that the reviewers construct the appropriate appraisal strategies from their respective interpersonal perspective to conform to the generic features of the discourse and the cultural context.
A case of a cervico-isthmic pregnancy without abnormal location of placenta
Authors: Yoshida Hiroko , Fujita Yasuyuki , Yumoto Yasuo , Hidaka Nobuhiro , Fukushima Kotaro , Kato Kiyoko 
Published: November 2014

Abstract
Cervico-isthmic pregnancies (CIP) are often complicated by massive hemorrhage due to placenta previa and adhesion. Herein, we present a case of CIP without placenta previa, complicated by cervical incompetency. A 39-year-old multiparous woman was diagnosed with CIP at 8 weeks. The placenta was located on the normal site, and no significant ultrasonographic findings were noted after 14 weeks. At 20 weeks, a cervical incompetency was complicated. A healthy infant was delivered by a cesarean hysterectomy at term. Histopathological examination confirmed CIP with placenta increta. In cases with CIP without placenta previa, the diagnosis during early gestation and careful evaluation of uterine cervix is essential to avoid severe complications.
Some Tauberian conditions obtained through weighted generator sequences
Authors: Belen Cemal 
Published: November 2014

Abstract
Recently, the concept of weighted
generator sequence has been introduced by Çanak and Totur
[Comput. Math. Appl. 62 (2011), no. 6, 2609–2615]. They proved that certain conditions in terms of
weighted generator sequences are Tauberian conditions for the
weighted mean method. In this paper, we present the necessary and
sufficient Tauberian conditions based on a weighted generator
sequence under which statistical convergence follows from
statistical summability by weighted means.
The role of serpins in tumor cell migration
Authors: Fortenberry Yolanda 
Published: November 2014

Abstract
Tumor cells are characterized by uncontrolled cell growth at a primary site that is caused by genetic alterations. Tumor cells that metastasize from their primary site to distant locations are commonly referred to as malignant. Cell migration is a critical step in this process. The ability of tumor cells to migrate and invade is partly controlled by proteolytic enzymes. These enzymes are secreted by either the tumor cells themselves or adjacent cells. They represent all classes of proteases, including serine and cysteine proteases. Serine proteases, in particular urokinase plasminogen activator (uPA), initiate a proteolytic cascade that culminates in degrading components of the extracellular matrix (ECM). Some serine proteases are controlled by a superfamily of proteins known as serpins. This minireview provides an overview of serpins that are vital in regulating tumor cell migration and progressing cancer.
Endothelial and metabolic disorders in adolescence: low birth weight is not an isolated risk factor
Authors: dos Santos Alves Priscila de Jesus , P.T. Henriques Ana Ciléia , Pinto Livia R.M. , S. Mota Rosa Maria , M. Alencar Carlos Henrique , Alves Renata S. , C. Carvalho Francisco Herlânio 
Published: November 2014

AbstractLow birth weight (LBW) seems to be a determining factor for many cardiovascular diseases in adult life.The objectives of this study were to investigate the occurrence of metabolic syndrome (MetS) and endothelial dysfunction in adolescents with LBW and compare them with subjects with normal birth weights (NBW).This retrospective cohort study evaluated 172 adolescents (86 in each group) aged 10–20 years, who were born in a reference maternity hospital. The following criteria were adopted: International Diabetes Federation parameters for the diagnosis of MetS and flow-mediated brachial artery dilatation for endothelial dysfunction. Student’s t-test or Mann-Whitney tests were used for continuous variables (depending on the normality of distribution evaluated by the Shapiro-Wilk test), and the Fisher exact test was used for categorical variables. The significance level was determined at 0.05.MetS was present in three cases of LBW and in four cases of NBW (p=0.70). The number of components of the syndrome was, on average, 0.6 and 0.5 in LBW and NBW, respectively (p=0.77). Endothelial dysfunction occurred in 25 (29.1%) cases of LBW and in 31 (36.1%) cases of NBW (p=0.33).LBW did not represent a risk factor in the occurrence of MetS or endothelial dysfunction in adolescence.
Inhibin B in adolescents and young adults with Turner syndrome
Authors: Messina Maria Francesca , Aversa Tommaso , Salzano Giuseppina , Costanzo Daria , Sferlazzas Concetta , Mirabelli Silvestro , Zirilli Giuseppina , Lombardo Fortunato 
Published: November 2014

AbstractPrimary gonadal failure may occur in most individuals with Turner syndrome (TS). Since ovaries in TS girls undergo premature apoptosis and cryopreservation of ovarian tissue is now feasible, it would be useful to identify a reliable marker of ovarian reserve in these patients. We planned to evaluate ovarian function in a group of TS patients by measuring both traditional markers and inhibin B and to compare these results with those of a control group.We enrolled 23 patients with TS and 17 age-matched healthy girls. The median age of our TS patients was 17.6 years. Three out of the 23 patients (13%) showed spontaneous pubertal development and regular menstrual cycles; the remaining 20 (86.9%) presented with primary amenorrhea.The median level of inhibin B in the TS patients with primary amenorrhea was 42 pg/mL and did not differ significantly among the different subgroups in relation to karyotype. The median inhibin B level in the control group was significantly higher than in the TS girls with primary amenorrhea (83 vs. 42 pg/mL, p<0.00001). In the three patients with TS and spontaneous menstrual cycles, the inhibin B levels were significantly higher when compared to the values of the TS girls with primary amenorrhea.TS patients with primary amenorrhea have significantly lower levels of inhibin B than TS girls with spontaneous puberty and healthy controls. Inhibin B does not correlate with follicle-stimulating hormone/luteinizing hormone. If our results are confirmed in further studies, inhibin B could become a first-line screening test for assessing ovarian reserve and a longitudinal marker of the possible decline of ovarian function in TS.