bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of stability indicating assay method for mitapivat: Identification of novel hydrolytic, photolytic, and oxidative forced degradation products employing quadrupole‐time of flight mass spectrometry
Authors: Bagul Manasi Ashok , Patil Yatesh , Mane Sayalee Sanjay , Kunnath Shaji Anandhu , Das Pintu , Ranjan Om Prakash , Dengale Swapnil Jayant 
Published: July 2024

Mitapivat is a novel, first‐in‐class orally active pyruvate kinase activator approved by the US Food and Drug Administration in 2022 for the treatment of hemolytic anemia. There is no literature available regarding the identification of degradation impurities of mitapivat. The present study deals with the degradation behavior of mitapivat under various stress conditions such as hydrolytic, photolytic, thermal, and oxidative stress. The multivariate analysis found that the independent variables, that is, molarity, temperature, and time, are interacting with each other to affect the degradation of mitapivat. A specific, accurate, and precise high‐performance liquid chromatographic (HPLC) method was developed to separate mitapivat from its degradation products. The separation was achieved on the C‐18 column (250 mm × 4.6 mm × 5 µm) using the combination of 0.1% formic acid buffer and acetonitrile in gradient elution profile. The method was validated as per the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use Q2(R2) guideline. LC‐electrospray ionization‐Quadrupole‐time of flight was employed to identify degradation products. A total of seven novel degradation products of mitapivat were identified based on tandem mass spectrometry and accurate mass measurement. In‐silico toxicity of mitapivat and its degradation products was qualitatively evaluated by the DEREK toxicity prediction tool.
Exploring residents' tourism support behaviors: A framework of the psychological perspective of the human‐place relationship
Authors: Song Huimin , Zeng Wei , Wu Mengjie 
Published: July 2024

AbstractBased on cognitive‐affective personality system theory and social exchange theory, this study establishes a psychological model of the human‐place relationship that reflects the process by which residents' tourism support for tourist destinations is formed and examines the mediating role of residents' tolerance and the chain‐mediated effect of residents' perceived tourism impact and tolerance. To test the hypothetical model, a survey of 405 residents of Quanzhou Ancient City, China, was conducted. The results confirm the relationships among psychological empowerment, place attachment, perceived tourism impact and tolerance on residents' tourism support behaviors. The findings contribute to residents' tourism support behaviors education and guidance.
An investigation of technological innovation and tourism industrial structure upgrading as drivers of tourism economic growth
Authors: Yang Chunyu , Yang Jiayu , Huang Jue , You Biying , Hong Huanzhou 
Published: July 2024

AbstractThis study focuses on the drivers of tourism economic growth with technological innovation and tourism industrial structure upgrading as the key predictors. An empirical study was done with panel data of 71 countries for 1996–2016. Three‐stage least squares (3SLS) regression with cross‐sectional fixed effects was applied to estimate the parameters. The results suggest that both predictors are the driving force for tourism economic growth. Moreover, the results reveal that technological innovation has significant negative effects on tourism industrial structure upgrading. This suggests that if technological development is not firmly anchored in the regional economic development, any one‐sided pursuit of technological innovation can produce a “decoupling” effect, which constrains the upgrading of tourism industrial structure. The study has important practical implications for policy formulation to sustain long‐term development of the tourism economy.
Self‐interest, ethical and environmental considerations of air traveler weight policies
Authors: Tolkach Denis , Pratt Stephen , Masiero Lorenzo , Jørgensen Matias Thuen , Zoltan Judit , Schuckert Markus , Chon Kaye 
Published: July 2024

AbstractThere is ongoing debate about whether airlines should charge passengers based on their weight. This study examines the ethics of three policies by surveying 1012 US air travelers: A Standard policy with a uniform price irrespective of the weight. A Threshold policy with a penalty if the body weight exceeds 160 pounds (72.6 kg). And a Unit‐of‐Body‐Weight policy with an individual price based on body and baggage weight. The study demonstrates levels of acceptance of these policies by different segments of passengers across various normative ethical theories. Younger generations were more accepting of alternatives to the current standard policy. Self‐interest was evident as a major influence of respondents' views. The core of the theoretical contribution highlights the importance of a differentiated view on, and separation of ethical and environmental issues in tourism research, as it shows, that the more environmentally sustainable choice may not be the more ethical one.
Formulation and Characterization of Lentil Milk–Based Soft Cheese Analogs: Insights on Physicochemical and Textural Properties
Authors: Naeem Hafsa , Akhtar Aqsa , Akram Nadia , Suleria Hafiz Ansar Rasul , Khalid Nauman 
Published: July 2024

ABSTRACTLentil milk–based soft cheese (LBC) is one of the emerging partial substitutes for animal milk‐based cheese. With time, more people want to reduce their meat and dairy intake for ethical, environmental, and chronic health–related concerns. This study focused on the formulation of LBC using milk extracted from green gram (S1 (6.5 g) of proteins), red gram (S2 (5 g) proteins), and black gram (S3 (3.5 g) proteins). All formulated LBC samples were investigated by determining proximate analysis, syneresis, viscosity, texture, color change, storage time, microbial count, and sensory attributes to evaluate the quality during 15 days of storage. The results reported that pH levels decreased for both S1 and S3, while S2 showed an increasing trend from Day 1 to Day 15. Viscosity and syneresis increased from Days 1 to 15 in S1, S2, and S3. Moreover, assessment of storage stability showed significant changes (p < 0.05) in the microbial count for S1 (7.89–4.98 CFU/mL), S2 (2.88–9.68 CFU/mL), and S3 (1.39–7.09 CFU/mL) from Day 1 to Day 15. The puncture force test reported that S1 showed a decreasing trend while S2 and S3 showed an increasing trend. The color attributes also showed a rising trend across all LBC samples. For sensory evaluation, LBC prepared using green gram showed the highest scores, particularly in appearance, texture, and color. Overall findings concluded the potential of lentil milk as a suitable ingredient for plant‐based soft cheese production, offering a new nutritious option for consumers with dietary preferences or restrictions.
Characterizing Dry Pea (Pisum sativum L.) for Improved Nutritional Traits and the Potential for Biofortification
Authors: Windsor Nathan , Boatwright Lucas , Boyles Rick , Bridges William , Rubiales Diego , Thavarajah Dil 
Published: July 2024

ABSTRACTDry pea (Pisum sativum L.) is a highly nutritious cool season food legume or pulse crop within the Fabaceae family that features high levels of protein (20%–25%), prebiotic carbohydrates, and a range of minerals and vitamins. Dry pea is cultivated globally in temperate climates and consumed as a whole food, snack, or protein powder. Dry pea is featured in plant‐based meat items such as the “beyond” branded plant‐based meats. Dry pea is an excellent candidate for plant‐based protein alternatives due to the high protein and low‐fat concentrations present in the mature seed, but improvements are still needed for more widespread use. Breeding efforts are ongoing to further improve dry pea proteins' quality, quantity, and digestibility through biofortification. Global dry pea germplasm contains a wide array of accessions that are vital for dry pea breeding efforts focused on developing cultivars enriched with the most bioavailable forms of plant‐based proteins. The objective of this review is to summarize prior research exploring the factors that contribute to the nutritional value of the dry pea—especially protein quality and quantity.
What's hot and what's not in the aquatic sciences—Understanding and improving news coverage
Authors: Downing John A. 
Published: July 2024

AbstractThe frequency of news reporting about scientific topics is positively related to public interest as well as to public support for science funding and public policy change. This correlation can also have positive impacts on individual scientific careers depending on the chosen subject area of research. Analysis of a public news database shows the frequency and trends in news reporting of several popular research areas in the aquatic sciences. The frequency of appearance of topics in the news varies over more than three orders of magnitude. Temporal trends in reporting vary from steeply increasing (+25% per year) to declining (−4% per year). Suggestions are offered concerning the framing of research topics and overall better communication of research findings to journalists and the general public. This understanding may increase news prominence, public interest, science funding, and policy change in aquatic research areas.
Mental illness and marketing: A 50‐year scoping review and future research framework
Authors: Farrell Justine Rapp , Machin Jane , Mirabito Ann M. , Drenten Jenna , Chan‐Park Christina , Crosby Elizabeth , Adkins Natalie Ross 
Published: July 2024

AbstractMarketing scholars wield untapped potential to expand research into the wellbeing of consumers with mental illness beyond existing clinical and medical perspectives, enriching the field with unique insights into consumer behavior, market dynamics, and strategic interventions. This scoping review maps over 50 years of research at the intersection of mental illness and marketing in business disciplines. We examine a corpus of 1064 peer‐reviewed journal articles using the population, concept, and context framework to integrate extant knowledge and identify research gaps. We present a comprehensive future‐facing research framework that highlights gaps at the consumer, market, policy, and society levels that marketing researchers are particularly qualified to investigate. Through a series of illustrative research directives, we highlight areas of opportunities for better understanding and addressing the interdependencies that exist within this complex and multidisciplinary domain.
Conceptualizing sustainable consumption priming: A scoping review
Authors: Hao Jianyu , Plangger Kirk , West Douglas 
Published: July 2024

AbstractWhile many psychological interventions encourage sustainable consumption by altering attitudes, these modified attitudes often do not result in sustainable choices leading to the need to test alternative interventions to facilitate sustainable consumption, such as priming. Priming uses stimuli that trigger nonconscious processing that influences decisions. Despite its popularity, studies that employ priming strategies in sustainable consumption research are widely dispersed across several conceptual domains. This article unpacks and summarizes different approaches to priming sustainable behavior by delineating theoretical and methodological perspectives in various contexts across diverse consumer characteristics. The method employed is a scoping review of 74 articles published over 23 years (2000–2022). The resulting review (1) provides an overview of priming in sustainable consumption, (2) highlights knowledge gaps, (3) identifies knowledge clusters, and (4) proposes a research agenda for future investigations. Primarily, this paper provides an integrated map that deconstructs how researchers have explored priming interventions to promote sustainable consumption and to enable the best, or at least, better practice.
Potential of Phenylalanine‐, Tryptophan‐, and Tyrosine‐MOF‐5 Composites for Selective Carbon Dioxide and Methane Adsorption
Authors: Moyosore Abdullahi , Ahmad Haslina , Latif Muhammad Alif Muhammad , Borzehandani Mostafa Yousefzadeh , AbdulRahman Mohd Basyaruddin , Abdelmalek Emilia 
Published: July 2024

AbstractMetal‐organic frameworks (MOFs) have emerged as versatile materials with exceptional properties, including high porosities, large surface areas, and remarkable stabilities, making them attractive for various applications. MOF‐5 stands out for its thermal stability and surface area, making it promising for diverse applications, including drug delivery and gas adsorption. This study explores the potential of amino acid MOF (AA‐MOF) composites, integrating phenylalanine, tryptophan, and tyrosine, for selective CO2 and CH4 adsorption using grand canonical Monte Carlo (GCMC) simulations. The impact of amino acid composition and spatial arrangement within MOF‐5 on selective CO2 and CH4 adsorption performance have been investigated. The results indicate that tryptophan‐MOF‐5 exhibits the highest CO2 uptake due to the interaction between CO2 and tryptophan, while phenylalanine‐MOF‐5 demonstrated the lowest affinity for gas adsorption. Radial distribution function (RDF) analysis reveals distinct gas distribution patterns within the composites, with tryptophan playing a dominant role in gas adsorption. Additionally, analysis of total energy, enthalpy of adsorption, and Henry's coefficient provide insights into the thermodynamic aspects of gas adsorption onto AA‐MOF composites. This study enhances the understanding of the fundamental mechanisms underlying CO2 and CH4 selective adsorption in amino acid MOF composites, facilitating the development of efficient gas separation technologies.
A novel high‐risk model identified by epithelial–mesenchymal transition predicts prognosis and radioresistance in rectal cancer
Authors: Qin Feiyu , Bian Zehua , Jiang Lingzhen , Cao Yulin , Tang Junhui , Ming Liang , Qin Yan , Huang Zhaohui , Yin Yuan 
Published: July 2024

AbstractMany studies have shown that tumor cells that survive radiotherapy are more likely to metastasize, but the underlying mechanism remains unclear. Here we aimed to identify epithelial–mesenchymal transition (EMT)‐related key genes, which associated with prognosis and radiosensitivity in rectal cancer. First, we obtained differentially expressed genes by analyzing the RNA expression profiles of rectal cancer retrieved from The Cancer Genome Atlas database, EMT‐related genes, and radiotherapy‐related databases, respectively. Then, Lasso and Cox regression analyses were used to establish an EMT‐related prognosis model (EMTPM) based on the identified independent protective factor Fibulin5 (FBLN5) and independent risk gene EHMT2. The high‐EMTPM group exhibited significantly poorer prognosis. Then, we evaluated the signature in an external clinical validation cohort. Through in vivo experiments, we further demonstrated that EMTPM effectively distinguishes radioresistant from radiosensitive patients with rectal cancer. Moreover, individuals in the high‐EMTPM group showed increased expression of immune checkpoints compared to their counterparts. Finally, pan‐cancer analysis of the EMTPM model also indicated its potential for predicting the prognosis of lung squamous cell carcinoma and breast cancer patients undergoing radiotherapy. In summary, we established a novel predictive model for rectal cancer prognosis and radioresistance based on FBLN5 and EHMT2 expressions, and suggested that immune microenvironment may be involved in the process of radioresistance. This predictive model could be used to select management strategies for rectal cancer.
Sensitivity of Advanced Magnetic Resonance Imaging to Progression over Six Months in Early Spinocerebellar Ataxia
Authors: Rezende Thiago J.R. , Petit Emilien , Park Young Woo , Tezenas du Montcel Sophie , Joers James M. , DuBois Jonathan M. , Moore Arnold H. , Povazan Michal , Banan Guita , Valabregue Romain , Ehses Philipp , Faber Jennifer , Coupé Pierrick , Onyike Chiadi U. , Barker Peter B. , Schmahmann Jeremy D. , Ratai Eva‐Maria , Subramony Sub H. , Mareci Thomas H. , Bushara Khalaf O. , Paulson Henry , Klockgether Thomas , Durr Alexandra , Ashizawa Tetsuo , Lenglet Christophe , Öz Gülin ,   READISCA Consortium
Published: July 2024

AbstractBackgroundClinical trials for upcoming disease‐modifying therapies of spinocerebellar ataxias (SCA), a group of rare movement disorders, lack endpoints sensitive to early disease progression, when therapeutics will be most effective. In addition, regulatory agencies emphasize the importance of biological outcomes.ObjectivesREADISCA, a transatlantic clinical trial readiness consortium, investigated whether advanced multimodal magnetic resonance imaging (MRI) detects pathology progression over 6 months in preataxic and early ataxic carriers of SCA mutations.MethodsA total of 44 participants (10 SCA1, 25 SCA3, and 9 controls) prospectively underwent 3‐T MR scanning at baseline and a median [interquartile range] follow‐up of 6.2 [5.9–6.7] months; 44% of SCA participants were preataxic. Blinded analyses of annual changes in structural, diffusion MRI, MR spectroscopy, and the Scale for Assessment and Rating of Ataxia (SARA) were compared between groups using nonparametric testing. Sample sizes were estimated for 6‐month interventional trials with 50% to 100% treatment effect size, leveraging existing large cohort data (186 SCA1, 272 SCA3) for the SARA estimate.ResultsRate of change in microstructural integrity (decrease in fractional anisotropy, increase in diffusivities) in the middle cerebellar peduncle, corona radiata, and superior longitudinal fasciculus significantly differed in SCAs from controls (P < 0.005), with high effect sizes (Cohen's d = 1–2) and moderate‐to‐high responsiveness (|standardized response mean| = 0.6–0.9) in SCAs. SARA scores did not change, and their rate of change did not differ between groups.ConclusionsDiffusion MRI is sensitive to disease progression at very early‐stage SCA1 and SCA3 and may provide a >5‐fold reduction in sample sizes relative to SARA as endpoint for 6‐month‐long trials. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Multisystem disorder associated with a pathogenic variant in CLCN7 in the absence of osteopetrosis
Authors: Lee Chung‐Lin , Chang Yeun‐Wen , Lin Hsiang‐Yu , Lee Hung‐Chang , Yeh Ting‐Chi , Fang Li‐Ching , Lee Ni‐Chung , Tsai Jeng‐Daw , Lin Shuan‐Pei 
Published: July 2024

AbstractBackgroundWe clinically and genetically evaluated a Taiwanese boy presenting with developmental delay, organomegaly, hypogammaglobulinemia and hypopigmentation without osteopetrosis. Whole‐exome sequencing revealed a de novo gain‐of‐function variant, p.Tyr715Cys, in the C‐terminal domain of ClC‐7 encoded by CLCN7.MethodsNicoli et al. (2019) assessed the functional impact of p.Tyr715Cys by heterologous expression in Xenopus oocytes and evaluating resulting currents.ResultsThe variant led to increased outward currents, indicating it underlies the patient's phenotype of lysosomal hyperacidity, storage defects and vacuolization. This demonstrates the crucial physiological role of ClC‐7 antiporter activity in maintaining appropriate lysosomal pH.ConclusionElucidating mechanisms by which CLCN7 variants lead to lysosomal dysfunction will advance understanding of genotype–phenotype correlations. Identifying modifier genes and compensatory pathways may reveal therapeutic targets. Ongoing functional characterization of variants along with longitudinal clinical evaluations will continue advancing knowledge of ClC‐7's critical roles and disease mechanisms resulting from its dysfunction. Expanded cohort studies are warranted to delineate the full spectrum of associated phenotypes.
Hybrid algorithms for SAR matrix compression and the impact of post‐processing on SAR calculation complexity
Authors: Orzada Stephan , Fiedler Thomas M. , Ladd Mark E. 
Published: July 2024

AbstractPurposeThis study proposes faster virtual observation point (VOP) compression as well as post‐processing algorithms for specific absorption rate (SAR) matrix compression. Furthermore, it shows the relation between the number of channels and the computational burden for VOP‐based SAR calculation.MethodsThe proposed new algorithms combine the respective benefits of two different criteria for determining upper boundedness of SAR matrices by the VOPs. Comparisons of the old and new algorithms are performed for head coil arrays with various channel counts. The new post‐processing algorithm is used to post‐process the VOP sets of nine arrays, and the number of VOPs for a fixed median relative overestimation is compared.ResultsThe new algorithms are faster than the old algorithms by a factor of two to more than 10. The compression efficiency (number of VOPs relative to initial number of SAR matrices) is identical. For a fixed median relative overestimation, the number of VOPs increases logarithmically with the number of RF coil channels when post‐processing is applied.ConclusionThe new algorithms are much faster than previous algorithms. Post‐processing is very beneficial for online SAR supervision of MRI systems with high channel counts, since for a given number of VOPs the relative SAR overestimation can be lowered.
Optimal enhanced backstepping method for trajectory tracking control of the wheeled mobile robot
Authors: Zhang Ke , Chai Bin , Tan Minghu 
Published: July 2024

AbstractThis paper proposes a novel control method applied to the trajectory tracking of the wheeled mobile robot. This method can solve the tracking difficulty caused by the non‐holonomic constraint and the under‐actuated properties. First, according to the kinematic and dynamic tracking error models, the desired velocities for trajectory tracking purposes are obtained. Second, the control method, consisting of an enhanced backstepping controller with fewer gains and an optimization algorithm, is designed. The actual trajectory of the mobile robot is exactly converged and kept at the predefined reference trajectory by the operation of this method. Next, this method with globally uniformly asymptotically stability is theoretically analyzed. Finally, simulation comparisons and physical experiments are conducted in different scenarios. The tracking performance is evaluated by three metrics, namely convergence speed, tracking accuracy and robustness, thus verifying the effectiveness of the novel control method.