bluuebunny/crossref_metadata_2025_split huggingface dataset:
GDC: An Integrated Resource to Explore the Pathogenesis of Hearing Loss through Genetics and Genomics
Authors: Cheng Hui , Wang Xuegang , Zhong Mingjun , Geng Jia , Li Wenjian , Pei Kanglu , Lu Yu , Cheng Jing , Bu Fengxiao , Yuan Huijun 
Published: August 2024

AbstractEffective research and clinical application in audiology and hearing loss (HL) often require the integration of diverse data. However, the absence of a dedicated database impeded understanding and insight extraction in HL. To address this, the Genetic Deafness Commons (GDC) was developed by consolidating extensive genetic and genomic data from 51 public databases and the Chinese Deafness Genetics Consortium, encompassing 5,983,613 variants across 201 HL genes. This comprehensive dataset detailed the genetic landscape of HL, identifying six novel mutational hotspots within DNA binding domains of transcription factor genes, which were eligible for evidence-based variant pathogenicity classification. Comparative phenotypic analyses highlighted considerable disparities between human and mouse models, with only 130 human HL genes exhibiting hearing abnormality in mice. Moreover, gene expression analyses in the cochleae of mice and rhesus macaques demonstrated a notable correlation (R2= 0.76). Utilizing gene expression, function, pathway, and phenotype data, a SMOTE-Random Forest model identified 18 candidate HL genes, includingTBX2andERCC2, newly confirmed as HL genes. The GDC, as a comprehensive and unified repository, significantly advances audiology research and clinical practice by enhancing data accessibility and usability, thereby facilitating deeper insights into hearing disorders.
Linguistic vitality improves health and wellbeing in Indigenous communities: a scoping review
Authors: Harding Louise , DeCaire Ryan , Delaurier-Lyle Karleen , Ellis Ursula , Schillo Julia , Turin Mark 
Published: August 2024

AbstractIntroductionWhile Indigenous communities have long recognized the importance of their languages for their wellbeing, this topic has only recently received attention in scholarship, research and public policy. This scoping review synthesizes and assesses existing literature on the links between Indigenous linguistic vitality and health or wellness in English-speaking settler colonial countries (Australia, Canada, New Zealand, and the United States).MethodsThe JBI methodology for scoping reviews was followed by an interdisciplinary research team. Key databases searched included MEDLINE, PsycInfo, and Cumulative Index to Nursing and Allied Health Literature. Searches were restricted to English language literature. The last search was on February 8, 2021. Quantitative and qualitative analyses were conducted to categorize and elucidate the nature of the links reported.ResultsOver 10,000 records were reviewed and 262 met the inclusion criteria – 70% academic and 30% gray literature. The largest number of studies focus on Canadian contexts. 78% of the original research studies report only supportive links between Indigenous languages and health, while 98% of the literature reviews report supportive links. Linguistic vitality tends to support health and wellness outcomes, while the diminishment of languages is associated with worse health. The most prevalent links with linguistic vitality are healthcare outcomes, overall health and healing, and mental, cognitive, and psychological health and development. The results of the remaining original research studies were mixed (10%), statistically non-significant (6%), adverse (5%) and neutral (1%).ConclusionsThe results of this scoping review suggest that linguistic vitality is a determinant of health for Indigenous peoples in the contexts studied. Recommendations for harnessing the healing effects of language include increasing tangible support to language programs, delivering linguistically tailored health care and promotion, and advancing knowledge through funding relevant community-engaged research and education.Article HighlightsOur interdisciplinary authorship team conducted a scoping review involving the screening of nearly 10,000 publications.262 academic and grey literature reports were published between 1949-2019 which had a central focus on exploring the links between Indigenous languages and health.78% of original research studies and 98% of reviews report exclusively supportive links between linguistic vitality and the health and wellness of Indigenous peoples.Key areas linked to health include healthcare outcomes, overall health and healing, and mental, cognitive, and psychological health and development.Linguistic vitality is a determinant of health for Indigenous peoples and should be leveraged through supporting language programs, delivering linguistically tailored care, and funding community-engaged research and education.
Single-residue effects on the behavior of a nascent polypeptide chain inside the ribosome exit tunnel
Authors: Pardo-Avila Fátima , Kudva Renuka , Levitt Michael , von Heijne Gunnar 
Published: August 2024

AbstractNascent polypeptide chains (NCs) are extruded from the ribosome through an exit tunnel (ET) traversing the large ribosomal subunit. The ET’s irregular and chemically complex wall allows for various NC-ET interactions. Translational arrest peptides (APs) bind in the ET to induce translational arrest, a property that can be exploited to study NC-ET interactions by Force Profile Analysis (FPA). We employed FPA and molecular dynamics (MD) simulations to investigate how individual residues placed in a glycine-serine repeat segment within an AP-stalled NC interact with the ET to exert a pulling force on the AP and release stalling. Our results indicate that large and hydrophobic residues generate a pulling force on the NC when placed ≳10 residues away from the peptidyl transfer center (PTC). Moreover, an asparagine placed 12 residues from the PTC makes a specific stabilizing interaction with the tip of ribosomal protein uL22 that reduces the pulling force on the NC, while a lysine or leucine residue in the same position increases the pulling force. Finally, the MD simulations suggest how the Mannheimia succiniproducens SecM AP interacts with the ET to promote translational stalling.Graphical Abstract
Mechanical control of the insect extracellular matrix nanostructure
Authors: Itakura Yuki , Wada Housei , Inagaki Sachi , Hayashi Shigeo 
Published: August 2024

SummaryNanoscale modifications of apical extracellular matrix (ECM) have created a variety of functional surfaces with distinct physical properties, as exemplified by structural coloration and superhydrophobicity in animals and plants1. While the surface nanostructures of various organisms have inspired numerous biomimetic applications, the biological mechanisms underlying ECM patterning at the nanoscale remain largely unknown. Here, we investigated the morphogenesis of cuticular pores inDrosophilaolfactory organs2,3. Hundreds of uniform-sized nanopores of ∼50 nm permit selective access of odorant molecules to olfactory neurons. We showed that matrices composed of the zona pellucida domain (ZPD) protein4–6cover sensory organs in cell type-specific patterns and combinations. The ZPD proteins Dyl, Tyn, Mey, and Nyo form matrices with specific mixing and sorting properties, restricting cell growth and movement. The disruption of ZPD matrices leads to detachment of the envelope layer of the cuticle from the plasma membrane, and reduced numbers and irregularly sized nanopores. Our results suggest that compressive force from the ECM is essential for robust nanopore morphogenesis. This work reveals a previously unrecognized role for ZPD proteins as modular units that establish the mechanical environment required to modulate the nanoscale assembly of cuticle materials, opening a new biological context to these biomimetically important structures.
The contronymity of project accounting for performing the relevance of project outcomes
Authors: Themsen Tim Neerup , Jacobsen Peter Holm , Tryggestad Kjell 
Published: August 2024

PurposeThis paper aims to advance recent literature on the performativity of accounting by examining how project accounting affects a project organization’s ability to deliver a relevant project outcome, such as a product or a building, for a receiving client organization.Design/methodology/approachThe paper draws on a longitudinal case study of a 41.4-billion-kroner (5.5-billion-euro) Danish project of constructing 16 new public hospitals. Its objective was to reduce the average unit costs and improve the quality of patient care. Each hospital construction was managed by a separate project organization and handed over to a separate receiving hospital organization. The project organizations applied a common approach to project accounting. The paper relies on Michel Callon’s concepts of performativity and sociotechnical agencement – approaching project accounting as an arrangement of devices.FindingsThe paper shows that the project-accounting agencement simultaneously supported and undermined the project organizations’ ability to deliver hospitals relevant to the receiving hospital organizations. The agencement performed hospital designs, disciplined project actors and guided decision-making, thus supporting the overall work of the project organizations. It also, however, compelled the project organizations to compromise on hospital designs when unexpected events occurred. These compromises led to the delivery of hospitals, which largely prevented the receiving hospital organizations from achieving the project’s objective.Originality/valueThis paper advances our limited understanding of the dynamic and complex relationship between project accounting and the relevance of project outcomes. It introduces the concept of a “contronymity device” to capture the way project accounting simultaneously produces two opposing consequences, both supporting and undermining the enactment of a particular reality. The paper lastly enriches our understanding of how project-accounting devices impact hospital organizations’ operating cost structures and challenge patient care capabilities.
Revisiting the ability of research and development activities to improve value relevance
Authors: Sulistiawan Dedhy , Rudiawarni Felizia Arni 
Published: August 2024

PurposeThis article aims to evaluate the informativeness of accruals on stock prices. Investors may misinterpret the information contained in accruals and produce accrual anomalies. Accruals accounting improves the quality of financial statements by providing useful information, although it also contains judgments and is less objective than operating cash-flows.Design/methodology/approachWe employ data panel regression analysis to investigate the value relevance of financial information. Our study takes the object of companies listed on the Nasdaq stock exchange (NASDAQ) as the representative of the prominent stock exchange for technology-driven enterprises and entrepreneurs. Expanding the findings, we also use Shanghai Stock Exchange (SSE) data.FindingsOur research finds that accruals are still relevant. However, firms with R&D expenditures reduce the ability of accruals to explain stock prices for non-technology firms and firms without intangible assets. After analyzing only tech firms (and firms with intangible assets), our tests show that R&D expenditures improve the relevancy of accruals. These findings apply to both Nasdaq and SSE.Practical implicationsPractitioners and the investment community get valuable insights into how the recognition and measurement of R&D expenditures affect the value relevance. Information about R&D increases relevancy only in firms with intangible assets and those that operate in the technology industry.Originality/valueOur paper provides benefits by using R&D expenses to affect accruals' informativeness by comparing two countries with different recognition of R&D.
The manner in which you craft your job depends on the context: evidence from Poland and China
Authors: Wojtczuk-Turek Agnieszka , Turek Dariusz , Tan Le , Gao Hanyu 
Published: August 2024

PurposeDrawing on the job demands-resources theory (JD-R), this study aims to discuss the relationship between paradoxical leadership and job crafting (approach and avoidance), considering the moderating role of overwork climate and organisational identification in two cultural context (China and Poland).Design/methodology/approachThe research was conducted on employees from diversified organisations in two different cultural context: China (N = 408) and Poland (N = 400). Statistical verifications of the three-way interaction effect were conducted with Jamovi version 2.3 and multigroup analysis with SPSS AMOS version 29.FindingsThe results showed that employees who perceive high levels of paradoxical leadership and overwork climate as well as possess a high level of organisational identification engage stronger in job crafting, both approach and avoidance. Moreover, the results demonstrated that the dimensions of culture: individualism-collectivism moderate the relationship between the variables tested, in such a way that the relationship is stronger with the lower level of individualism.Research limitations/implicationsThis study has two limitations: its cross-sectional design and the use of self-reported questionnaire data.Originality/valueThe study expands knowledge of the relationship between paradoxical leadership and job crafting in two different cultural contexts.
The determinants of IT audit usage in Saudi Arabia with specific reference to computer audit assisted tools
Authors: Almaqtari Faozi A. 
Published: August 2024

Purpose
The purpose of this study is to investigate the determinants and the intention to use information technology (IT) audit technologies.

Design/methodology/approach
The research model explores the external and internal factors that influence IT audit usage in Saudi Arabia. The external factors include IT audit education, professional support provided by professional accounting and auditing bodies, external pressure and social factors. The internal factors include the firm’s organizational support, complexity of accounting information systems, IT audit competency, adoption risk, ease of use and readiness. These factors affect the intention to use IT audits, represented by the perceived benefits and intention to use IT audits, which in turn affect IT audit usage. The study uses structural equation modelling to estimate a sample size of 261 respondents.

Findings
The findings suggest that internal factors significantly influence both IT audit usage and intention to use IT audits. However, the external factors exhibit insignificant associations with IT audit usage. The findings also indicate that IT auditors in Saudi Arabia heavily rely on Microsoft Excel, Microsoft Word and email/Outlook as essential IT audit tools. However, the findings reveal that there is still a role for specialized IT audit tools such as generalized audit software and Audit Command Language but this usage is marginal.

Practical implications
The present study provides significant insights for auditors, companies’ boards, professional bodies and policymakers to enhance the development and usage of IT audits. The study revealed the absence of supportive external factors that policymakers and professional bodies should exercise in this regard. The findings also indicate that IT audit education and capacity programmes are required to promote competency and adoption of IT audit technologies.

Originality/value
The study contributes to IT auditing by identifying significant factors influencing IT audit adoption. It underlines the relevance of internal and external determinants and perceived benefits as drivers of IT audit adoption. The current study provides an original piece of research that highlights a comprehensive investigation of the determinates of IT audit usage in a developing country that is shifting towards artificial intelligence and IT advancements.
Unlocking trade potential: gender equality, economic complexity and trade openness in the Developing-8 (D-8) countries
Authors: Sajid Saima , Hassan Syed Saqlain Ul , Rehman Shafique Ur , Arooj Maryam , Sadekin Md Nazmus 
Published: August 2024

PurposePrioritizing the shift from a traditional economy towards complex integrated economies has been the top priority among policymakers to achieve sustainable development goals (SDGs). Countries involved in economic integration must safeguard their labor markets. The Developing-8 (D-8) is an alliance of economic cooperation including Bangladesh, Egypt, Indonesia, Iran, Malaysia, Nigeria, Pakistan and Turkey, all of which are among the world’s largest labor-abundant countries but have insufficient attention toward labor market policies, especially in gender roles. This issue motivated this study, which aims to investigate the impact of economic complexity on trade through with the interaction of gender equality.Design/methodology/approachThe annual data for the panel of D-8 countries from 1990 to 2020 were collected. The Driscoll and Kraay (D-K) regression was employed for empirical investigation after observing the presence of autocorrelation, heteroscedasticity and cross-sectional dependency (CSD) across the sample.FindingsFindings show that the economic complexity index (ECI) and gender equality (GE) have a significant impact on trade openness (TO). Moreover, the interaction of GE and ECI strengthens the relationship between ECI and TO. Therefore, both factors worked together to enhance the trading system by supplying the nation with highly sophisticated and complex products.Research limitations/implicationsPolicymakers in D-8 countries should enable equal access to resources, investment and decision-making for both men and women. This leads toward stubble, innovative and complex products that enhance trade and goodwill in the international market.Originality/valueThis study incorporated GE as an interaction term in economic complexity and TO in D-8 countries for the first time, to the best of the authors' knowledge.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-11-2023-0908
The role of source attractiveness and source credibility in advertising field hockey: a minority sport
Authors: Gazley Aaron , Coombes Jamie 
Published: August 2024

PurposeThe purpose of this research is to examine the extent to which source attractiveness and source credibility (or skill in a sporting context) provide an effective marketing strategy for Field Hockey in New Zealand, a minority sport Minority sports struggle to generate capital and have minimal sponsorship backing due to small participation and viewership rates compared to “major sports”. By understanding how source attractiveness and source credibility work in the context of a minority sport such as hockey, more effective advertising towards target audiences can be achieved. We also consider differences between advertising to players and no-players of the sport. This is the first research to consider these issues.Design/methodology/approachFour advertisements were created in an experimental design that manipulated the two variables: source credibility and source attractiveness, in an advertisement promoting Hockey. A survey was conducted, using an online questionnaire.FindingsResults show that a mixture physical attractiveness and skill (credibility) increase attitudes towards the advertisement. This results in positive intentions to both watch and play hockey. When the respondents were segmented into hockey players and non-hockey players, only skill is effective for the Hockey Player segment, whereas both skill and attractiveness are effective for non-players.Research limitations/implicationsFuture research should include comparing hockey to further minority sports codes. Additionally, understanding if male models created the same effects would be particularly interesting for further research.Practical implicationsManagement should focus on skill, with physical attractiveness being considered, but not as the most important attribute. If targeting hockey players, skill needs to be especially visible. Even though these elements could be argued to be within the “proverbial eye of the beholder”, the results have shown that in terms of sports advertising, it is possible to portray these two attributes in a generalised way.Originality/valueThis research to focuses on source credibility and attractiveness in a minority sporting context, in particular field hockey, whereas the majority of research considers major sporting codes. In addition, involvement with the sport is also considered.
Echoes of dysfunction: a thematic exploration of toxic leadership in higher education
Authors: Azeez Fousia , Aboobaker Nimitha 
Published: August 2024

Purpose
Numerous studies have examined effective or positive leadership styles and their effects on employees and organizational outcomes. In recent years, toxic leadership has drawn the attention of several organizations, and toxic managers undoubtedly harm an organization’s social, economic and individual quality of life. This study aims to examine academicians’ perceptions of toxic leadership behavior exhibited by their immediate leaders in the higher education sector.

Design/methodology/approach
A qualitative interpretive phenomenological research design was used, and data was analyzed using Clarke & Braun’s thematic analysis method. Data were collected through individual semi-structured interviews with 26 teachers from the technical education sector within higher education who had five years or more of experience in the higher education sector.

Findings
Five themes emerged from the teacher's narratives based on the research questions that were framed with the help of expert opinions and a thorough literature review (“frequency of occurrences,” “outward behavior,” “repercussions,” “coping strategies” and “support mechanisms”). Using the NVIVO 14.0 software, auto-coded themes were generated and corroborated with the findings. The triangulation of outcomes reveals toxic behaviors exhibited by the leaders in universities and colleges, which conforms with the toxic leadership literature.

Originality/value
This study advances the understanding of the harmful or toxic side of leadership, specifically in the higher education sector. This work advances earlier studies in the field by examining teachers’ perceptions of toxic leadership behavior exhibited by their leaders in the higher education sector. The study continues by highlighting areas of toxic leadership research that are yet to be explored in academic literature and are still to be studied.