bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and clinical significance of tertiary lymphoid structures in OSCC
Authors: Yao Mianfeng , Yang Tianru , Li Qiulan , Zhang Xinle , Zheng Ziran , Li Jiang , Huang Jiajun , Sun Yuanxin , Gao Xing , Fang Changyun 
Published: July 2024

AbstractObjectivesThis study aimed to investigate the characteristics of tertiary lymphoid structures (TLSs) in oral squamous cell carcinoma (OSCC) and their association with clinical and pathological features.Materials and Methods12 TLS‐related chemokines in TCGA database were analyzed to investigate the TLSs in OSCC. The density, maturity, and location of TLSs in a large cohort of 189 OSCC patients (114 of which had clinical and prognostic information) were assessed. And the significance between TLSs and clinicopathologic characteristics was analyzed.ResultsBioinformatics and analysis showed that TLSs were associated with better clinical outcomes in OSCC. Histological staining and analysis showed that the overall survival rate of the high‐density group (71/112, 63.4%) was significantly higher (p < 0.0001) than that of the low‐density group (41/112, 36.6%), and the high‐density group had fewer lymph node metastases (50.0%/68.3%, p = 0.021). And TLSs were divided into 4 types according to the maturity and location. Different types of TLSs are associated with prognosis (OS, p < 0.0001), clinical features (T stage, p = 0.028; degree of differentiation, p = 0.043), and precancerous lesion types (OSF, p = 0.049) of OSCC patients.ConclusionTLSs were closely associated with better OSCC prognosis, and a more systematic classification may better guide the formulation of further treatment options.
The invertase gene PWIN1 confers chilling tolerance of rice at the booting stage via mediating pollen development
Authors: Wang Yanli , Gong Chunyan , Liu Lingtong , Wang Tai 
Published: July 2024

AbstractPollen fertility is a primary regulator of grain yield and is highly susceptible to cold and other environmental stress. We revealed the roles of rice cell wall invertase gene PWIN1 in pollen development and chilling tolerance. We uncovered its preferential expression in microspores and bicellular pollen and identified its knock‐down and knock‐out mutants. pwin1 mutants produced a higher proportion of abnormal pollen than wild‐type plants. The contents of sucrose, glucose, and fructose were increased, while ATP content and primary metabolism activity were reduced in the mutant pollen. Furthermore, the loss of function of PWIN1 coincided with an increase in SnRK1 activity and a decrease in TOR activity. Under chilling conditions, pwin1 mutants displayed significantly reduced pollen viability and seed‐setting rate, while overexpressing PWIN1 notably increased pollen viability and seed‐setting rate as compared with the wild‐type, indicating that PWIN1 is essential for rice pollen development and grain yield under cold stress. This study provides insights into the molecular mechanisms underlying rice pollen fertility during chilling stress, and a new module to improve chilling tolerance of rice at the booting stage by molecular design.
Efficacy of aprepitant for refractory pruritus in patients with epidermolysis bullosa and atopic dermatitis: A retrospective study
Authors: Hartzell Cheryl J. , Szabova Alexandra , Collins Andrew B. , Morel Armand N. , Mijatovic Desimir , Goldschneider Kenneth R. 
Published: July 2024

AbstractIntroductionAt a single‐center pediatric hospital, the neurokinin‐1 receptor antagonist aprepitant was used to treat refractory pruritus in epidermolysis bullosa (EB) and atopic dermatitis (AD).MethodsThirty‐seven patients were included (24 EB patients, 13 AD patients), ages 10 months to 37 years.Results58% (14/24) of patients with EB and 85% (11/13) of patients with AD reported aprepitant was effective in decreasing their pruritus, with age‐related differences in efficacy observed in EB patients, and access to the medication by insurance denial or availability of the drug as a barrier to use.ConclusionsAprepitant shows promise in controlling refractory pruritus in pediatric EB and AD patients and deserves further study.
Is rapid urbanisation in Africa jeopardising the health and education of the population?
Authors: Ngounou Borice Augustin , Tekam Oumbe Honoré , Fowagap Jean‐Marie Gankou , Domguia Edmond Noubissi 
Published: July 2024

AbstractImproving and achieving better health and education is one of the main objectives of the Sustainable Development Goals (SDGs), and there is an extremely fertile literature on this issue. Therefore, in this paper, we study the impact of urbanisation on health and education in a sample of 49 African countries. To this end, we specify and estimate panel data models using fixed effects methods, the Driscoll–Kraay method, whose robustness has been demonstrated by Lewbel, 2SLS and the Kinky least squares method over the period 1996–2020. Our results suggest that urbanisation has a positive impact on healthcare spending and education in African countries. We obtain the same result by regional zone (North and West Africa), by level of development (Low Middle‐Income Countries) and by dominant religion (Christianity) with the exception of Central Africa, East Africa, Southern Africa, Middle Income Countries and Islamic religion and Others. Similarly, our results reveal that although urbanisation significantly worsens healthcare spending and significantly improves education in African countries, this result may be further amplified by the level of development and religious practices. This result remains the same when we take into account public (national government health expenditure) and private (private health insurance and household consumption expenditure on health) health expenditure, as well as secondary and tertiary education enrolment rates, with the exception of reducing external support for health in government, where urbanisation rather contributes to its reduction. Furthermore, taking into account other health measures, such as life expectancy at birth, prevalence of undernutrition, birth rate, prevalence of tuberculosis and mortality rate, our results indicate that urbanisation plays an important role. This leads to an increase in life expectancy, a higher prevalence of undernutrition, an increase in the birth rate and a decrease in tuberculosis and mortality rates. We therefore suggest that the governments of African countries invest in advanced information and communication technologies and encourage their adoption, particularly among marginalised populations, as these new tools have the potential to considerably improve health outcomes. These technologies make it possible to monitor and manage epidemics and sexually transmitted diseases more effectively. They can also facilitate better training in health and education, leading to better results in both areas.
Mapping Black geographies
Authors: Hawthorne Camilla 
Published: July 2024

AbstractThis paper unfolds in three parts. In Part 1, I describe how I have contended with the fraught relationships among mapping, nationalism, and colonialism in my teaching and research. When writing my first book, Contesting Race and Citizenship, I had to reckon with the positivist impulse to enumerate and map Black Italianness—and, more broadly, with the politics of visibility at a time of increasingly virulent racial nationalisms, xenophobia, and outright anti‐Black violence. In Part 2, I describe the ways my own thinking about mapping has been pushed in new directions by insights from Black geographies. Drawing on Clyde Woods, Katherine McKittrick, and Édouard Glissant—as well as essays from the edited volume The Black Geographic—I argue that Black geographic counter‐cartographies foreground insurgent Black spatial knowledges and practices that have always exceeded racial‐spatial violence, and approach mapping as both a material and poetic process. In Part 3, I conclude by advancing some tentative ideas about what it might mean to map new or alternative geographies of abolitionist struggle that attend to the interconnections between Black Atlantic and Black Mediterranean histories of racial capitalism.
The sharp doubling threshold for approximate convexity
Authors: van Hintum Peter , Keevash Peter 
Published: July 2024

AbstractWe show for of equal volume and that if , then (up to translation) is bounded. This establishes the sharp threshold for the quantitative stability of the Brunn–Minkowski inequality recently established by Figalli, van Hintum, and Tiba, the proof of which uses our current result. We additionally establish a similar sharp threshold for iterated sumsets.
Practical updates in clinical antiviral resistance testing
Authors: Wang Hannah 
Published: July 2024

ABSTRACT

The laboratory diagnosis of antiviral resistance is a quickly changing field due to new drug availability, the sunsetting of older drugs, the development of novel technologies, rapid viral evolution, and the financial/logistic pressures of the clinical laboratory. This mini-review summarizes the current state of clinically available antiviral resistance testing in the United States in 2024, covering the most commonly used test methods, mechanisms, and clinical indications for herpes simplex virus, cytomegalovirus, human immunodeficiency virus, influenza, hepatitis B virus, and hepatitis C virus drug resistance testing. Common themes include the move away from phenotypic to genotypic methods for first-line clinical testing, as well as uncertainty surrounding the clinical meaningfulness of minority variant detection as next-generation sequencing methods have become more commonplace.
Complete genome of
Priestia filamentosa
H146 isolated from tobacco leaves
Authors: Gao Qin , Yang Mengmeng , Ji Yuan , Hu Liwei , Dong Xiangzhou , Liang Taibo , Zhai Zhen , Cheng Yanming , Dai Huaxin , Zhao Limei , Zhang Guo , Zhou Qifa 
Published: July 2024

ABSTRACT

We report the complete genome of
Priestia filamentosa
H146 isolated from tobacco leaves. H146 contained a circular chromosome and five circular plasmids. A total of 4,669 genes were predicted, of which 4,372 genes were in the chromosome and other genes were located on plasmids. The genome sequence data provide an important basis for studying
Priestia filamentosa
.
Associations of Pap test utilisation with comorbidity and functional impairment among middle-aged non-Hispanic black women in the USA: a cross-sectional analysis of the 2018 BRFSS data
Authors: Zhu Zhikai , Wang Yali , Han Jiefei , Li Yang 
Published: July 2024

Objectives
Limited evidence exists on the association of Pap test utilisation with comorbidity and functional impairment among middle-aged non-Hispanic black (NHB) women in the USA. We aimed to assess whether middle-aged NHB women with a higher burden of comorbidity and functional impairment have a lower rate of Pap test utilisation.

Design
Nationwide cross-sectional survey in the USA.

Setting
2018 Behavioral Risk Factor Surveillance System.

Participants
6359 middle-aged NHB women.

Exposures and outcome
The primary exposures were comorbidity and functional impairment. The outcome of interest was whether a woman reported having a Pap test in the last 3 years.

Data analysis
We fit unadjusted and multivariable logistic regression models to calculate ORs and 95% CI for comorbidity and functional impairment. Sensitivity analysis was restricted to women without a history of hysterectomy or cancer. We added interaction terms between exposures and age, as well as lifestyle indicators.

Results
Of the 6359 women, 4141 (65.1%) had comorbidity and 2429 (38.2%) had functional impairment. Middle-aged NHB women with comorbidity (≥2 vs 0, aOR=0.72, 95% CI=0.61 to 0.85, p trend<0.01) or functional impairment (≥2 vs 0, aOR=0.69, 95% CI=0.57 to 0.83, p trend<0.01) had a lower rate of Pap test utilisation compared with healthier counterparts, regardless of histories of hysterectomy and prior cancer. The analyses for age and lifestyle indicators subgroup difference indicated no statistically significant effect (p interaction>0.05). However, the magnitude of these associations was stronger among women with adverse lifestyle factors (eg, comorbidity ≥2 v.s. 0, aOR=0.53, 95% CI=0.40, to 0.71; functional impairment ≥2 v.s. 0, aOR=0.35, 95% CI=0.16, to 0.72 among binge drinkers).

Conclusion
Comorbidity or functional impairment could be a potential barrier to Pap test utilisation among middle-aged NHB women in the USA. Our study highlights the importance of implementing targeted intervention programmes and prioritised health resource allocation to promote Pap test utilisation. Cohort studies with clear temporality and indicators reflecting disease severity will be essential for further understanding this association.
Immune cell topography of head and neck cancer
Authors: Muijlwijk Tara , Nijenhuis Dennis N L M , Ganzevles Sonja H , Ekhlas Fatima , Ballesteros-Merino Carmen , Peferoen Laura A N , Bloemena Elisabeth , Fox Bernard A , Poell Jos B , Leemans C René , Brakenhoff Ruud H , van de Ven Rieneke 
Published: July 2024

BackgroundApproximately 50% of head and neck squamous cell carcinomas (HNSCC) recur after treatment with curative intent. Immune checkpoint inhibitors are treatment options for recurrent/metastatic HNSCC; however, less than 20% of patients respond. To increase this response rate, it is fundamental to increase our understanding of the spatial tumor immune microenvironment (TIME).MethodsIn total, 53 HNSCC specimens were included. Using a seven-color multiplex immunohistochemistry panel we identified tumor cells, CD163+macrophages, B cells, CD8+T cells, CD4+T helper cells and regulatory T cells (Tregs) in treatment-naive surgical resection specimens (n=29) and biopsies (n=18). To further characterize tumor-infiltrating CD8+T cells, we stained surgical resection specimens (n=12) with a five-color tumor-resident panel including CD103, Ki67, CD8 and pan-cytokeratin. Secretome analysis was performed on matched tumor suspensions (n=11) to measure protein levels.ResultsBased on CD8+T cell infiltrates, we identified four different immunotypes: fully infiltrated, stroma-restricted, immune-excluded, and immune-desert. We found higher cytokine levels in fully infiltrated tumors compared with other immunotypes. While the highest immune infiltrates were observed in the invasive margin for all immune cells, CD163+macrophages and Tregs had the highest tendency to infiltrate the tumor center. Within the tumor center, especially B cells stayed at the tumor stroma, whereas CD163+macrophages, followed by T cells, were more often localized within tumor fields. Also, B cells were found further away from other cells and often formed aggregates while T cells and CD163+macrophages tended to be more closely located to each other. Across resection specimens from various anatomical sites within the head and neck, oral cavity tumors exhibited the highest densities of Tregs. Moreover, the distance from B cells and T cells to tumor cells was shortest in oral cavity squamous cell carcinoma (OCSCC), suggesting more interaction between lymphocytes and tumor cells. Also, the fraction of T cells within 10 µm of CD163+macrophages was lowest in OCSCC, indicating fewer myeloid/T-cell suppressive interactions in OCSCC.ConclusionsWe comprehensively described the TIME of HNSCC using a unique data set of resection specimens. We discovered that the composition, as well as the relative localization of immune cells in the TIME, differed in distinct anatomical sites of the head and neck.
A Brief Review of Electronic and Magnetic Structure of TIF3
Authors: Fernando Gayanath W. , Sheets Donal , Hancock Jason , Ernst Arthur , Matthias Geilhufe R. 
Published: July 2024

Materials with perovskite structure are known to exhibit fascinating physical properties such as high-temperature superconductivity, negative thermal expansion (NTE) and colossal magnetoresistance. However, transition metal trifluoride perovskites are less well studied compared to their oxide counterparts though they display marked differences such as NTE behavior in ScF3. Doping of such MF3 perovskites has been the focus of the experimental work of Morelock et al. [ 1 ] which provides a comprehensive structural study of the material class Sc1[Formula: see text]Ti[Formula: see text]F3. As shown in Fig. 1, there is a structural phase transition assumed to be tied to tilting of corner sharing octahedrons in this class of crystal structures which is believed to have an electrostatic dipolar origin, seen for example even in AlF3 [ 2 ]. However, the insulating and magnetic properties of TiF3 are closely related to the transition metal 3d-electrons. The extra valence [Formula: see text]-electron that Ti carries compared to Sc [ 1 , 3 ] gives rise to unusual electronic and magnetic properties.
Pathophysiologic Vasodilation in Cardiogenic Shock and Its Impact on Mortality
Authors: Chavez Miguel A. , Anderson McHale , Kyriakopoulos Christos P. , Scott Monte , Dranow Elizabeth , Maneta Eleni , Hamouche Rana , Taleb Iosif , Leon Jacy , Kogelschatz Benjamin , Goldstein Jake , Billia Filio , Baran David A. , Tehrani Behnam , Goodwin Matt , Selzman Craig H. , Tonna Joseph E. , Fang James C. , Drakos Stavros G. , Hanff Thomas C. 
Published: July 2024

BACKGROUND:
Cardiogenic shock (CS) mortality remains near 40%. In addition to inadequate cardiac output, patients with severe CS may exhibit vasodilation. We aimed to examine the prevalence and consequences of vasodilation in CS.

METHODS:
We analyzed all patients hospitalized at a CS referral center who were diagnosed with CS stages B to E and did not have concurrent sepsis or recent cardiac surgery. Vasodilation was defined by lower systemic vascular resistance (SVR), higher norepinephrine equivalent dose, or a blunted SVR response to pressors. Threshold SVR values were determined by their relation to 14-day mortality in spline models. The primary outcome was death within 14 days of CS onset in multivariable-adjusted Cox models.

RESULTS:

This study included 713 patients with a mean age of 60 years and 27% females; 14-day mortality was 28%, and 38% were vasodilated. The median SVR was 1308 dynes•s•cm
−5
(interquartile range, 870–1652), median norepinephrine equivalent was 0.11 µg/kg per minute (interquartile range, 0–0.2), and 28% had a blunted pressor response. Each 100-dynes•s•cm
−5
decrease in SVR below 800 was associated with 20% higher mortality (adjusted hazard ratio, 1.23;
P
=0.004). Each 0.1-µg/kg per minute increase in norepinephrine equivalent dose was associated with 15% higher mortality (adjusted hazard ratio, 1.12;
P
<0.001). A blunted pressor response was associated with a nearly 2-fold mortality increase (adjusted hazard ratio, 1.74;
P
=0.003).

CONCLUSIONS:

Pathophysiologic vasodilation is prevalent in CS and independently associated with an increased risk of death. CS vasodilation can be identified by SVR <800 dynes•s•cm
−5
, high doses of pressors, or a blunted SVR response to pressors. Additional studies exploring mechanisms and treatments for CS vasodilation are needed.
Bridging the COSMOS: How the Inclusion of and Collaboration with Faith-Based Understandings and Indigenous Knowledges Can Transform the Weather, Water, and Climate Enterprise
Authors: Martinez Carlos J. , Das Debanjana , Bloomfield Emma Frances , Abraham James D. , Knox John A. , Simmonds Ricardo , Hilderbrand Douglas C. , Giovannettone Jason , Gouw Arvin M. , RoyChowdhury Abhishek 
Published: July 2024

Abstract
Climate change is a global existential threat with far-reaching implications for natural ecosystems, biodiversity, and human societies. Adapting to and mitigating climate change require global cooperation and participation from all mindsets and belief systems, including the traditionally western weather, water, and climate enterprise (WWCE), faith-based understandings (FBUs), and Indigenous Knowledges (IKs). Epistemological differences and language barriers between knowledges and the historical marginalization and exploitation of IKs by western ideologies and some FBUs make coproduction and relationship building challenging. Acknowledging their historical tensions and distinctions, there is meaningful overlap between the WWCE, FBUs, and IKs on environmental stewardship, justice, and mental health. This article highlights three themes at the intersection of FBUs, IKs, and environmentalism: 1) increasing faith-based and Indigenous community resilience to weather extremes; 2) developing kindergarten through grade 12 (K-12) and collegiate weather, water, and climate education that weaves FBUs and IKs; and 3) increasing communication flows between weather, water, and climate science, and faith-based and Indigenous communities. These initiatives aim to foster relationships and trust between the WWCE, faith-based, and Indigenous communities; transform the WWCE into a multiknowledge enterprise; and promote a climate-resilient society. The American Meteorological Society’s Committee on Spirituality, Multifaith Outreach, and Science (COSMOS) plays a pivotal role in facilitating dialogue and collaboration on these themes while acknowledging distinctions and historical tensions between FBUs, IKs, and the WWCE. Collaborative efforts between the WWCE, faith-based, and Indigenous communities hold immense potential for addressing climate challenges, fostering resilience, and building a more inclusive and sustainable future grounded in mutual respect and understanding.
The impacts of stress and loneliness on gambling and gaming problems: A nationwide longitudinal study
Authors: Vuorinen Ilkka , Savolainen Iina , Sirola Anu , Oksanen Atte 
Published: July 2024

Background: Problems related to gambling and digital gaming have been a topic of concern for years. Less attention has been paid to the probable psychosocial factors behind these problems. While previous studies have established links between stress, loneliness, and addiction, there is a lack of longitudinal research investigating how stress and loneliness affect addictive behaviors, including problem gambling and gaming. Aims: This study uses multilevel mixed-effects generalized linear models to analyze the between- and within-person effects of stress and loneliness on gambling and gaming problems. The interaction between stress and loneliness was also investigated. Methods: A representative sample of Finns ( N = 1,530) answered a survey in 6-month intervals between spring 2021 and autumn 2023; 49.22% of the sample took part at all six time points. The Problem Gambling Severity Index and the Internet Gaming Disorder Test were used to measure gambling and gaming problems. The three-item UCLA Loneliness Scale was used to assess loneliness, and the Perceived Stress Scale was used to evaluate stress. Results: After controlling for gender and age, loneliness was found to increase only gaming problems at both the between- and within-person levels, but not gambling. In contrast, stress enhanced both gambling and gaming problems at the between- and within-person levels. Additionally, loneliness and stress were found to have negative interaction suggesting that their combined effect was lower than their separate effects. Conclusion: The findings provide longitudinal insight into the psychosocial vulnerabilities behind problem gambling and gaming, which can be helpful in designing targeted interventions.