bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linear Array Double Difference Adjoint Ambient Noise Tomography of the Central Tanlu Fault Zone, Eastern China
Authors: Yan Mengxuan , Yao Huajian , Lei Ting , Luo Song , Feng Jikun 
Published: July 2024

AbstractIn response to the need for high‐resolution imaging of shallow crustal structure, we present a linear array double‐difference (DD) adjoint tomography method, using DD Rayleigh wave traveltime measurements for enhanced spatial resolution. This method, validated through synthetic experiments, improves velocity anomaly detection with fewer iterations compared to absolute traveltime measurements. Applied to data from four linear seismic arrays in the central Tanlu fault zone (TLFZ) in the eastern China, our approach integrated both DD and absolute difference (AD) of adjoint traveltime measurements. We performed cluster analysis for data quality control, reducing data outliers and increasing reliability, particularly in suppressing cycle skipping for short‐period measurements. The resulting high‐resolution S‐wave velocity profiles in the shallow crust well delineate geological structures, revealing a continuous low‐velocity anomaly beneath the eastern branch of TLFZ. Our comparative analysis with the southern segment of TLFZ further highlights the segmented nature of the fault zone structure. These variations might suggest a dominant influence of deep magmatic processes due to destruction of the North China Craton. Our study links shallow structural features to deeper geodynamic activities, emphasizing the role of TLFZ as a critical tectonic boundary.
Fine Sediment in Mixed Sand‐Silt Environments Impacts Bedform Geometry by Altering Sediment Mobility
Authors: de Lange S. I. , Niesten I. , van de Veen S. H. J. , Baas J. H. , Lammers J. , Waldschläger K. , Boelee D. , Hoitink A. J. F. 
Published: July 2024

AbstractGeometric characteristics of subaqueous bedforms, such as height, length and leeside angle, are crucial for determining hydraulic form roughness and interpreting sedimentary records. Traditionally, bedform existence and geometry predictors are primarily based on uniform, cohesionless sediments. However, mixtures of sand, silt and clay are common in deltaic, estuarine, and lowland river environments, where bedforms are ubiquitous. Therefore, we investigate the impact of fine sand and silt in sand‐silt mixtures on bedform geometry, based on laboratory experiments conducted in a recirculating flume. We systematically varied the fraction of sand and silt for different discharges, and utilized an acoustic Doppler velocimeter to measure flow velocity profiles. The final bed geometry was captured using a line laser scanner. Our findings reveal that the response of bedforms to an altered fine sediment percentage is ambiguous, and likely depends on, among others, bimodality‐driven bed mobility and sediment cohesiveness. When fine, non‐cohesive material (fine sand or coarse silt) is mixed with the base material (medium sand), an increased dune height and length is observed, possibly caused by the hiding‐exposure effect, resulting in enhanced mobility of the coarser material. However, weakly cohesive fine silt suppresses dune height and length, possibly caused by reduced sediment mobility. Finally, in the transition from dunes to upper stage plane bed, there are indications that the bed becomes unstable and dune heights vary over time. The composition of the bed material does not significantly impact the hydraulic roughness, but mainly affects roughness via the bed morphology, especially the leeside angle.
The m6A methyltransferase METTL14 promotes cell proliferation via SETBP1-mediated activation of PI3K-AKT signaling pathway in myelodysplastic neoplasms
Authors: Jiang Lingxu , Zhang Yudi , Qian Jiejing , Zhou Xinping , Ma Liya , Zhu Shuanghong , Wang Lu , Wang Wei , Yang Wenli , Luo Yingwan , Lang Wei , Xu Gaixiang , Ren Yanling , Mei Chen , Ye Li , Zhang Qi , Liu Xiaozhen , Jin Jie , Sun Jie , Tong Hongyan 
Published: July 2024

AbstractN6-methyladenosine (m6A) is the most prevalent epitranscriptomic modification in mammalian mRNA. Recent studies have revealed m6A is involved in the pathogenesis of various malignant tumors including hematologic neoplasms. Nevertheless, the specific roles of m6A modification and m6A regulators in myelodysplastic neoplasms (MDS) remain poorly understood. Herein, we demonstrated that m6A level and the expression of m6A methyltransferase METTL14 were elevated in MDS patients with bone marrow blasts ≥5%. Additionally, m6A level and METTL14 expression were upregulated as the disease risk increased and significantly associated with adverse clinical outcomes. Knockdown of METTL14 inhibited cell proliferation and colony formation ability of MDS cells. Moreover, in vivo experiments showed METTL14 knockdown remarkably reduced tumor burden and prolonged the survival of mice. Mechanistically, METTL14 facilitated the m6A modification of SETBP1 mRNA by formation of METTL3-METTL14 complex, leading to increased stabilization of SETBP1 mRNA and subsequent activation of the PI3K-AKT signaling pathway. Overall, this study elucidated the involvement of the METTL14/m6A/SETBP1/PI3K-AKT signaling axis in MDS, highlighting the therapeutic potential of targeting METTL3-METTL14 complex-mediated m6A modification for MDS therapy.
Immune and neural response to acute social stress in adolescent humans and rodents
Authors: Gabbay Vilma , Ely Benjamin A. , Vileisis Julia N. , Petrovic Zorica , Cicvaric Ana , Asnis Gregory M. , Kim-Schulze Seunghee , Radulovic Jelena 
Published: July 2024

AbstractStudies in adults have linked stress-related activation of the immune system to the manifestation of psychiatric conditions. Using a translational design, this study aimed to examine the impact of social stress on immune activity in adolescents and on neuronal activity in a preclinical mouse model. Participants were 31 adolescents (ages 12–19), including 25 with mood and anxiety symptoms. Whole-blood samples were collected before and after the Trier Social Stress Test (TSST), a stress-inducing public speaking task, then cultured for 6 hours in the presence and absence of the inflammatory endotoxin lipopolysaccharide (LPS). Effects of TSST and LPS on 41 immune biomarkers were examined using repeated-measures analysis of variance. Separately, juvenile (8-week-old) male mice were non-stressed or exposed to reminder social defeat then intraperitoneally injected with saline or LPS (n = 6/group). Brains were perfused and collected for immunohistochemistry and confocal microscopy at 0, 1, 6, and 24 hours post-injection. The activity was determined by the density of cFos-positive neurons in the paraventricular hypothalamus, paraventricular thalamus, and basolateral amygdala, regions known to show sustained activation to immunological challenge. Analyses in the adolescent study indicated a strong effect of LPS but no effects of TSST or TSST×LPS interaction on immune biomarkers. Similarly, reminder social defeat did not induce sustained neuronal activity changes comparable to LPS immunological challenge in juvenile mice. Our convergent findings across species suggest that the acute immune response to stress documented in adults is not present in youth. Thus, aging and chronicity effects may play an important role in the inflammatory response to acute psychosocial stress.
IgG replacement in multiple myeloma
Authors: Wonnaparhown Alex , Hilal Talal , Squire Jacqueline , Freeman Catherine , Fonseca Rafael 
Published: July 2024

AbstractT cell engagers (TCE) such as chimeric antigen receptor (CAR) T cell therapy and bispecific antibodies (BiAbs) for the treatment of multiple myeloma (MM) have significantly improved clinical outcomes, but have also raised awareness for ensuing post-treatment secondary immunodeficiency and hypogammaglobulinemia (HG). As patients with MM live longer, recurrent infections become a significant component of therapy-associated morbidity and mortality. Treatment of HG with immunoglobulin G replacement therapy (IgG-RT) has been a mainstay of the primary immunodeficiency (PI) world, and extrapolation to MM has recently started to show promising clinical outcomes. However, IgG-RT initiation, dosing, route, timing, monitoring, and management in MM has not been standardized in the setting of TCE. Progress in MM treatment will involve greater recognition and screening of underlying secondary immunodeficiency, identification of risk-stratification markers, optimizing IgG-RT management, and implementing other approaches to decrease the risk of infection. In this review, we summarize infection risk, risk of HG, and management strategies for IgG-RT in patients with relapsed MM after TCE.
Predictive value of serum inflammatory markers in retinopathy of prematurity
Authors: Kıran Yenice Eşay , Kara Caner , Karsli Türkoglu Tijen , Ulubaş Işık Dilek , Çelik İstemi Han 
Published: July 2024

Abstract
Purpose
To evaluate the relationship between the development of retinopathy of prematurity (ROP) and neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR).

Material and methods
The medical records of 153 preterm infants born before the 34th week of gestation, were retrospectively reviewed. Complete blood cell (CBC) and C-reactive protein (CRP) results measured within the first 24 h of life were recorded. NLR, LMR and PLR were calculated by dividing neutrophil count by lymphocyte count, lymphocyte count by monocyte count, and platelet count by lymphocyte count, respectively. Analysis of possible risk factors related with ROP development was evaluated using logistic regression analysis. Results were compared between infants with and without ROP.

Results
A total of 153 infants, of which 64 (41.9%) with ROP and 89 (58.1%) without ROP, were included in the study. While lymphocyte count and LMR were found to be significantly lower in infants with ROP (p = 0.015 and p = 0.044), neutrophil count and NLR were found to be significantly higher (p = 0.021 and p = 0.046, respectively). No significant difference were observed in platelet and monocyte count and PLR (p = 0.808, p = 0.170 and p = 0.075, respectively). Multivariate logistic regression analysis revealed that gestational age, birth weight and NLR were major risk factors for the development of ROP (OR:0.59; p = 0.01, OR:1.00; p = 0.02 and OR: 2.56; p = 0.02, respectively).

Conclusion
This study supports that, in addition to prematurity, NLR on the first postnatal day has a significant predictive value in ROP.
Universal subunit vaccine protects against multiple SARS-CoV-2 variants and SARS-CoV
Authors: Wang Gang , Verma Abhishek K. , Shi Juan , Guan Xiaoqing , Meyerholz David K. , Bu Fan , Wen Wei , Liu Bin , Li Fang , Perlman Stanley , Du Lanying 
Published: July 2024

AbstractAlthough Omicron RBD of SARS-CoV-2 accumulates many mutations, the backbone region (truncated RBD) of spike protein is highly conserved. Here, we designed several subunit vaccines by keeping the conserved spike backbone region of SARS-CoV-2 Omicron BA.1 subvariant (S-6P-no-RBD), or inserting the RBD of Delta variant (S-6P-Delta-RBD), Omicron (BA.5) variant (S-6P-BA5-RBD), or ancestral SARS-CoV-2 (S-6P-WT-RBD) to the above backbone construct, and evaluated their ability to induce immune responses and cross-protective efficacy against various SARS-CoV-2 variants and SARS-CoV. Among the four subunit vaccines, S-6P-Delta-RBD protein elicited broad and potent neutralizing antibodies against all SARS-CoV-2 variants tested, including Alpha, Beta, Gamma, and Delta variants, the BA.1, BA.2, BA.2.75, BA.4.6, and BA.5 Omicron subvariants, and the ancestral strain of SARS-CoV-2. This vaccine prevented infection and replication of SARS-CoV-2 Omicron, and completely protected immunized mice against lethal challenge with the SARS-CoV-2 Delta variant and SARS-CoV. Sera from S-6P-Delta-RBD-immunized mice protected naive mice against challenge with the Delta variant, with significantly reduced viral titers and without pathological effects. Protection correlated positively with the serum neutralizing antibody titer. Overall, the designed vaccine has potential for development as a universal COVID-19 vaccine and/or a pan-sarbecovirus subunit vaccine that will prevent current and future outbreaks caused by SARS-CoV-2 variants and SARS-related CoVs.
Early Cretaceous troodontine troodontid (Dinosauria: Theropoda) from the Ohyamashimo Formation of Japan reveals the early evolution of Troodontinae
Authors: Kubota Katsuhiro , Kobayashi Yoshitsugu , Ikeda Tadahiro 
Published: July 2024

AbstractA new troodontid dinosaur, Hypnovenator matsubaraetoheorum gen. et sp. nov., is described based on an articulated postcranial skeleton recovered from the fluvial deposits of the Albian Ohyamashimo Formation of the Sasayama Group in Tambasasayama City, Hyogo Prefecture, Japan. Hypnovenator is distinguished from other troodontids by four autapomorphies and a combination of additional features. Our phylogenetic analysis positions Hypnovenator as the oldest and one of the most basal troodontines, forming a clade with Gobivenator mongoliensis. The discovery of Hypnovenator suggests that small-bodied maniraptorans with a sleeping posture were common not only in environments with volcanic and eolian events or alluvial systems but also in fluvial systems. Geometric morphometric analysis of manual ungual phalanges shows that manual ungual phalanges I and III of Hypnovenator exhibit considerable morphological variation but are functionally similar, which differs from those of non-troodontine troodontids, reflecting the transition of manual motion within Troodontinae. Hypnovenator also has mosaic features in the pes related to cursoriality. This study reveals that asymmetrical arctometatarsus occurred by the Albian, and some morphological changes, such as shorter digit IV than digit III and non-ungual phalanges of digits III with roller joints and digit IV with weakly ginglymoid articulation, arose during the early Late Cretaceous.
LPAM: A lightweight medical segmentation network based on Mamba improved by prompt attention
Authors: Hu Kaiqi , Xu Chudong 
Published: July 2024

AbstractPresently, State Space Models (SSMs), including frameworks like Mamba, have been incorporated into the realm of computer vision. These models not only sustain remote interactions and encapsulate global semantic information effectively, but also preserve linear computational complexity, offering a balance between performance and computational efficiency. Given that Mamba inherently adheres to the principle of selectivity when constructing sequence models, the goal is to further unleash the potential of Mamba through this innovative combination of convolution and self‐attention, improve accuracy and minimize the number of parameters while achieving linear complexity. Mamba is employed as an encoder to distill semantic information from the image, and it is supplemented with convolutional blocks, thereby conserving the details of the image. Concurrently, embedding prompts at a deeper level enhances its adaptability to cater to diverse requirements. Lastly, a bidirectional attention mechanism is incorporated for inference, striving to retain both global connections and local details to the maximum extent. This culminates in a novel, lightweight medical segmentation model. Exhaustive experiments were executed on six public datasets. The empirical results show that the proposed model exhibits competitive performance in medical image segmentation tasks.
Circular synthetic aperture radar sub‐aperture angle information complementation based on azimuth‐controllable generative adversarial network
Authors: Li Bingxuan , Ma Yanheng , Chu Lina , Li Wei , Shi Yuanping 
Published: July 2024

AbstractA conditional generative adversarial network (CGAN) framework is proposed to address the issue of incomplete circular synthetic aperture radar (CSAR) azimuthal information due to motion errors. Specifically, the authors propose a novel CGAN architecture that can control the azimuth angle for arbitrary angle generation, capable of complementing missing CSAR sub‐aperture information. The network incorporates angular labels for various scenarios and integrates a dynamic region‐aware convolution (DRconv) module. Additionally, to counteract the common challenge of mode collapse in GAN training, a mode seeking regularisation technique is innovativrly introduced into the authors’ loss function. The efficacy of the proposed network is rigorously tested using both the MSTAR dataset and an X‐band SAR dataset. The results demonstrate that the authors’ network can generate high‐fidelity SAR images with controllable azimuths, closely resembling authentic images. Furthermore, the proposed method excels in complementing missing CSAR sub‐aperture information, effectively supplying the lost angular information due to motion errors. A new technical approach for SAR image generation is not only offered but it also has the potential to significantly expand SAR datasets. This advancement is expected to enhance the quality and utility of SAR imagery in applications such as surveillance, reconnaissance, and environmental monitoring.
Multi‐source DOA estimation based on multi‐UAV collaboration in complex GNSS spoofing environments
Authors: Zhou Jianwei , Wang Wenjie , Zhang Chenhao 
Published: July 2024

AbstractUnmanned Aerial Vehicles (UAVs) are widely used in both military and civilian sectors due to their maneuverability and versatility. However, UAVs rely on the Global Navigation Satellite System (GNSS) for real‐time accurate navigation and are therefore vulnerable to attacks, particularly spoofing attacks, in GNSS‐challenging environments. Furthermore, UAV payloads are generally limited to carrying only a single antenna, significantly restricting the spatial Degrees of Freedom (DoFs) available. A new scheme is presented to address the challenges posed by multiple spoofing sources for UAV GNSS navigation. Unlike conventional multi‐antenna techniques, our approach extends centralised multi‐antenna Direction of Arrival (DOA) estimation to distributed scenarios using UAV collaboration techniques. The multi‐source DOA estimation of GNSS spoofing is achieved using the space‐time DOA matrix (ST‐DOAMatrix) technique, which enhances system resilience and spatial DoFs. Simulation results validate the effectiveness of the proposed method and demonstrate the feasibility and potential of the technique in ensuring the proper and safe operation of UAVs using GNSS navigation.
Large Interferometer For Exoplanets (LIFE)
Authors: Alei E. , Quanz S. P. , Konrad B. S. , Garvin E. O. , Kofman V. , Mandell A. , Angerhausen D. , Mollière P. , Meyer M. R. , Robinson T. , Rugheimer S. ,   the LIFE Collaboration
Published: July 2024

Context. Following the recommendations to NASA (in the Astro2020 Decadal survey) and ESA (through the Voyage2050 process), the search for life on exoplanets will be a priority in the next decades. Two concepts for direct imaging space missions are being developed for this purpose: the Habitable Worlds Observatory (HWO) and the Large Interferometer for Exoplanets (LIFE). These two concepts operate in different spectral regimes: HWO is focused on reflected light spectra in the ultraviolet, visible, and near-infrared (UV/VIS/NIR), while LIFE will operate in the mid-infrared (MIR) to capture the thermal emission of temperate exoplanets.
Aims. In this study, we aim to assess the potential of HWO and LIFE to characterize a cloud-free Earth twin orbiting a Sun-like star at a distance of 10 pc, both as separate missions and in synergy with each other. We aim to quantify the increase in information that can be gathered by joint atmospheric retrievals on a habitable planet.
Methods. We performed Bayesian retrievals on simulated data obtained by an HWO-like mission and a LIFE-like one separately, then jointly. We considered the baseline spectral resolutions currently assumed for these concepts and used two increasingly complex noise simulations, obtained using state-of-the-art noise simulators.
Results. An HWO-like concept would allow one to strongly constrain H2O, O2, and O3 in the atmosphere of a cloud-free Earth twin, while the atmospheric temperature profile is not well constrained (with an average uncertainty ≈100 K). LIFE-like observations would strongly constrain CO2, H2O, and O3 and provide stronger constraints on the thermal atmospheric structure and surface temperature (down to ≈10 K uncertainty). For all the investigated scenarios, both missions would provide an upper limit on CH4. A joint retrieval on HWO and LIFE data would accurately define the atmospheric thermal profile and planetary parameters. It would decisively constrain CO2, H2O, O2, and O3 and find weak constraints on CO and CH4. The significance of the detection is in all cases greater than or equal to the single-instrument retrievals.
Conclusions. Both missions provide specific information that is relevant for the characterization of a terrestrial habitable exoplanet, but the scientific yield can be maximized by considering synergistic studies of UV/VIS/NIR+MIR observations. The use of HWO and LIFE together will provide stronger constraints on biosignatures and life indicators, with the potential to be transformative for the search for life in the Universe.
KMT-2021-BLG-2609Lb and KMT-2022-BLG-0303Lb: Microlensing planets identified through signals produced by major-image perturbations
Authors: Han Cheongho , Albrow Michael D. , Lee Chung-Uk , Chung Sun-Ju , Gould Andrew , Hwang Kyu-Ha , Jung Youn Kil , Ryu Yoon-Hyun , Shvartzvald Yossi , Shin In-Gu , Yee Jennifer C. , Yang Hongjing , Zang Weicheng , Cha Sang-Mok , Kim Doeon , Kim Dong-Jin , Kim Seung-Lee , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W. 
Published: July 2024

Aims. We investigate microlensing data collected by the Korea Microlensing Telescope Network (KMTNet) survey during the 2021 and 2022 seasons to identify planetary lensing events displaying a consistent anomalous pattern. Our investigation reveals that the light curves of two lensing events, KMT-2021-BLG-2609 and KMT-2022-BLG-0303, exhibit a similar anomaly, in which short-term positive deviations appear on the sides of the low-magnification lensing light curves.
Methods. To unravel the nature of these anomalies, we meticulously analyze each of the lensing events. Our investigations reveal that these anomalies stem from a shared channel, wherein the source passed near the planetary caustic induced by a planet with projected separations from the host star exceeding the Einstein radius. We find that interpreting the anomaly of KMT-2021-BLG-2609 is complicated by the “inner–outer” degeneracy, whereas for KMT-2022-BLG-0303, there is no such issue despite similar lens-system configurations. In addition to this degeneracy, interpreting the anomaly in KMT-2021-BLG-2609 involves an additional degeneracy between a pair of solutions, in which the source partially envelops the caustic and the other three solutions in which the source fully envelopes the caustic. As in an earlier case of this so-called von Schlieffen–Cannae degeneracy, the former solutions have substantially higher mass ratio.
Results. Through Bayesian analyses conducted based on the measured lensing observables of the event time scale and angular Einstein radius, the host of KMT-2021-BLG-2609L is determined to be a low-mass star with a mass ~0.2 M⊙ in terms of a median posterior value, while the planet’s mass ranges from approximately 0.032 to 0.112 times that of Jupiter, depending on the solutions. For the planetary system KMT-2022-BLG-0303L, it features a planet with a mass of approximately 0.51 MJ and a host star with a mass of about 0.37 M⊙. In both cases, the lenses are most likely situated in the bulge.