bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stromal cell–derived factor-1 promoted angiogenesis and inflammatory cell infiltration in aneurysm walls
Authors: Hoh Brian L. , Hosaka Koji , Downes Daniel P. , Nowicki Kamil W. , Wilmer Erin N. , Velat Gregory J. , Scott Edward W. 
Published: October 2013

Object
A small percentage of cerebral aneurysms rupture, but when they do, the effects are devastating. Current management of unruptured aneurysms consists of surgery, endovascular treatment, or watchful waiting. If the biology of how aneurysms grow and rupture were better known, a novel drug could be developed to prevent unruptured aneurysms from rupturing. Ruptured cerebral aneurysms are characterized by inflammation-mediated wall remodeling. The authors studied the role of stromal cell–derived factor-1 (SDF-1) in inflammation-mediated wall remodeling in cerebral aneurysms.

Methods
Human aneurysms, murine carotid artery aneurysms, and murine intracranial aneurysms were studied using immunohistochemistry. Flow cytometry analysis was performed on blood from mice developing carotid or intracranial aneurysms. The effect of SDF-1 on endothelial cells and macrophages was studied by chemotaxis cell migration assay and capillary tube formation assay. Anti–SDF-1 blocking antibody was given to mice and compared with control (vehicle)-administered mice for its effects on the walls of carotid aneurysms and the development of intracranial aneurysms.

Results
Human aneurysms, murine carotid aneurysms, and murine intracranial aneurysms all expressed SDF-1, and mice with developing carotid or intracranial aneurysms had increased progenitor cells expressing CXCR4, the receptor for SDF-1 (p < 0.01 and p < 0.001, respectively). Human aneurysms and murine carotid aneurysms had endothelial cells, macrophages, and capillaries in the walls of the aneurysms, and the presence of capillaries in the walls of human aneurysms was associated with the presence of macrophages (p = 0.01). Stromal cell–derived factor-1 promoted endothelial cell and macrophage migration (p < 0.01 for each), and promoted capillary tube formation (p < 0.001). When mice were given anti–SDF-1 blocking antibody, there was a significant reduction in endothelial cells (p < 0.05), capillaries (p < 0.05), and cell proliferation (p < 0.05) in the aneurysm wall. Mice given anti–SDF-1 blocking antibody developed significantly fewer intracranial aneurysms (33% vs 89% in mice given control immunoglobulin G, respectively; p < 0.05).

Conclusions
These data suggest SDF-1 is associated with angiogenesis and inflammatory cell migration and proliferation in the walls of aneurysms, and may have a role in the development of intracranial aneurysms.
Stereotactic radiosurgery for arteriovenous malformations of the cerebellum
Authors: Bowden Greg , Kano Hideyuki , Tonetti Daniel , Niranjan Ajay , Flickinger John , Lunsford L. Dade 
Published: October 2013

Object
Arteriovenous malformations (AVMs) of the posterior fossa have an aggressive natural history and propensity for hemorrhage. Although the cerebellum accounts for the majority of the posterior fossa volume, there is a paucity of stereotactic radiosurgery (SRS) outcome data for AVMs of this region. The authors sought to evaluate the long-term outcomes and risks of cerebellar AVM radiosurgery.

Methods
This single-institution retrospective analysis reviewed the authors' experience with Gamma Knife surgery during the period 1987–2007. During this time 64 patients (median age 47 years, range 8–75 years) underwent SRS for a cerebellar AVM. Forty-seven patients (73%) presented with an intracranial hemorrhage. The median target volume was 3.85 cm3 (range 0.2–12.5 cm3), and the median marginal dose was 21 Gy (range 15–25 Gy).

Results
Arteriovenous malformation obliteration was confirmed by MRI or angiography in 40 patients at a median follow-up of 73 months (range 4–255 months). The actuarial rates of total obliteration were 53% at 3 years, 69% at 4 years, and 76% at 5 and 10 years. Elevated obliteration rates were statistically higher in patients who underwent AVM SRS without prior embolization (p = 0.005). A smaller AVM volume was also associated with a higher rate of obliteration (p = 0.03). Four patients (6%) sustained a hemorrhage during the latency period and 3 died. The cumulative rates of AVM hemorrhage after SRS were 6% at 1, 5, and 10 years. This correlated with an overall annual hemorrhage rate of 2.0% during the latency interval. One patient experienced a hemorrhage 9 years after confirmed MRI and angiographic obliteration. A permanent neurological deficit due to adverse radiation effects developed in 1 patient (1.6%) and temporary complications were seen in 2 additional patients (3.1%).

Conclusions
Stereotactic radiosurgery proved to be most effective for patients with smaller and previously nonembolized cerebellar malformations. Hemorrhage during the latency period occurred at a rate of 2.0% per year until obliteration occurred.
Le silence, à l'adolescence, a une voix
Authors: Le Fourn Jean-Yves 
Published: October 2013

La voix résonne sur fond de silence. L’enfant, être parlé, est appelé à devenir un être qui parle. Dès lors, comment entendre le silence de l’adolescent ? L’auteur de cet article nous invite à distinguer différents types de silences à l’adolescence, et rappelle, à l’heure de la transparence, que le silence est un temps logique de construction du sujet adolescent, comme le silence du thérapeute est nécessaire, sous conditions, à la prise de parole du sujet lui-même.
Abdominal cocoon
Authors: Sureka Binit , Mittal Mahesh Kumar , Sinha Mukul , Mittal Aliza , Thukral Brij Bhushan 
Published: October 2013

AbstractAbdominal cocoon is an acquired benign condition in which there is encapsulation of bowel loops by a fibrous membrane. Pre-operative clinical diagnosis is usually difficult. Imaging plays a critical role in timely and accurate diagnosis. We present a brief discussion on this topic with relevant imaging findings.
De la responsabilité individuelle au « vivre ensemble » : une recherche-action sur la sanction à l’école
Authors: Ollivier Christian , Paltrinieri Luca 
Published: October 2013

Nous rendons compte ici de la conduite d’une recherche-action sur la sanction dans deux classes d’une section BAC Professionnel d’une école de l’environnement de la Chambre de Commerce de Paris. Nous présentons la problématique de recherche à partir d’une perspective historique pour expliciter les présupposés théoriques de notre recherche et des solutions que nous avons esquissées : repenser collectivement les règles du « vivre ensemble » au lieu de réformer tout simplement le système de sanction. Nous décrivons ensuite la co-construction et l’évaluation d’un dispositif de recherche-action basé sur la participation active des étudiants, des enseignants, des chercheurs et qui a pour but de reformuler certaines parties du règlement de l’école.
L’apprentissage du vivre ensemble par la pratique du dialogue philosophique en classe : propos d’adolescents
Authors: Gagnon Mathieu , Couture Élisabeth , Yergeau Sébastien 
Published: October 2013

L’apprentissage du vivre ensemble est considéré par l’UNESCO (2010) comme une mission éducative fondamentale. Seulement, au-delà de la noblesse de cette finalité, se pose la question des moyens et stratégies à mettre en place afin de rencontrer les composantes associées à un tel apprentissage, dont l’ouverture d’esprit, la tolérance, l’attention, le respect des différences, l’écoute, l’autocritique, l’autocorrection... En ce sens, certaines études tendent à montrer des liens entre la pratique du dialogue philosophique (PDP) et le développement du jugement moral (Leleux, 2009 ; Robert, Roussin, Ratte et Guèye, 2009). Cependant, ces études portent essentiellement sur des enfants et ne prennent pas en compte le point de vue des élèves. Les résultats exposés à l’intérieur du présent article s’appuient sur une enquête menée auprès de 97 élèves du secondaire pratiquant la philosophie sur une base régulière. Selon 94% d’entre eux, la PDP a des impacts positifs sur leurs relations avec les autres. Ces apports sont présentés à partir de 7 catégories émergentes, à savoir: ouverture d’esprit, pensée critique et habiletés intellectuelles, pratique réflexive, vie courante, pratique dialogique, résolutions de conflits et entraide, questionnement éthique.
Peut-on enseigner le vivre-ensemble ?
Authors: Plante Maxime 
Published: October 2013

La nécessité de former au vivre-ensemble témoigne du caractère problématique de celui-ci. Pourquoi le vivre-ensemble est-il problématique sinon parce qu’il sous-entend qu’il nous faut à tout prix coexister, soi et l’autre, c’est-à-dire vivre ensemble dans la différence ? Le respect d’une telle injonction grâce au support de l’éducation est-il possible ? Deux écueils à éviter tracent la voie à emprunter. Celui, d’une part, d’une éducation dont l’herméneutique ne peut que violer le principe de respect de l’altérité au moment même où elle prétend l’enseigner. De l’autre, celui de considérer l’éthique simplement comme ouverture totale à la différence. Entre ces deux écueils, une voie difficile à négocier, celle d’une responsabilité face à des choix éducatifs immanquablement voués à trahir l’Autre.
Soustraite aux regards, une éducation alternative d’enfants « placés » dans une famille illettrée
Authors: Derycke Marc 
Published: October 2013

Se rendant invisible de par son illettrisme, une « famille d’accueil » reçoit des enfants rendus invisibles eux aussi, en ce que, retirés à leur famille, ils sont intégrés avec les enfants biologiques. Certains de ces enfants placés présentent des problèmes de comportement qui nuisent au vivre ensemble dans l’espace domestique. Le matériau empirique est prélevé selon une méthode ethnographique liant son interprétation dans le cadre d’une démarche dialectique associant chercheurs, enquêtés et professionnels (« sensing »). Il est encadré par une réflexion philosophique portant sur la prise de part au monde commun développée par Rancière (1987). Les résultats positifs que le couple obtient enrichissent cette orientation ; elle peut servir de source d’inspiration.
Osteopathic Manipulative Treatment in Tarsal Somatic Dysfunction: A Case Study
Authors: Batt Joshua , Neeki Michael M. 
Published: October 2013

Abstract
The authors present a case of a 24-year-old woman with left foot pain that began after an inversion injury obtained while running. The pain minimally improved with nonsteroidal anti-inflammatory medications. Clinical examination revealed a relatively normal foot with palpable changes in the bony structures at the midfoot consistent with a tarsal subluxation. Cuboid reduction was performed using high-velocity, low-amplitude manipulation, after which the patient reported immediate and near-complete pain relief. The authors also review mechanisms of injury, clinical findings, and treatment modalities for patients with tarsal subluxation.
Aerosol optical depths over oceans: A view from MISR retrievals and collocated MAN and AERONET in situ observations
Authors: Witek Marcin L. , Garay Michael J. , Diner David J. , Smirnov Alexander 
Published: October 2013

AbstractIn this study, aerosol optical depths over oceans are analyzed from satellite and surface perspectives. Multiangle Imaging SpectroRadiometer (MISR) aerosol retrievals are investigated and validated primarily against Maritime Aerosol Network (MAN) observations. Furthermore, AErosol RObotic NETwork (AERONET) data from 19 island and coastal sites is incorporated in this study. The 270 MISR/MAN comparison points scattered across all oceans were identified. MISR on average overestimates aerosol optical depths (AODs) by 0.04 as compared to MAN; the correlation coefficient and root‐mean‐square error are 0.95 and 0.06, respectively. A new screening procedure based on retrieval region characterization is proposed, which is capable of substantially reducing MISR retrieval biases. Over 1000 additional MISR/AERONET comparison points are added to the analysis to confirm the validity of the method. The bias reduction is effective within all AOD ranges. Setting a clear flag fraction threshold to 0.6 reduces the bias to below 0.02, which is close to a typical ground‐based measurement uncertainty. Twelve years of MISR data are analyzed with the new screening procedure. The average over ocean AOD is reduced by 0.03, from 0.15 to 0.12. The largest AOD decrease is observed in high latitudes of both hemispheres, regions with climatologically high cloud cover. It is postulated that the screening procedure eliminates spurious retrieval errors associated with cloud contamination and cloud adjacency effects. The proposed filtering method can be used for validating aerosol and chemical transport models.
Polychlorinated biphenyls and dibenzofurans in patients with yusho and their toxicological significance: A review
Authors: Masuda Yoshito , Yoshimura Hidetoshi 
Published: October 2013

AbstractThe rice oil ingested by the patients with Yusho and their blood, liver, and adipose tissue were analyzed for individual congeners of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). The individual congeners identified were examined for accumulation in the liver of monkeys and rats, inducing activities of benzo[a]pyrene 3‐hydroxylase, benzphetamine demethylase, and DT‐diaphorase in rats, and gravimetric changes of the thymus and liver in rats. Among the six PCB congeners detected in Yusho patients, 2,3,4,5,3′,4′‐hexa‐CB seems to be the compound most related to Yusho judging from its strong enzyme‐inducing activities in the liver and the thymus atrophy and liver hypertrophy caused by feeding it to rats. PCDF congeners identified in the patients' tissues showed a stronger toxicity in rats than these PCBs, exhibiting stronger enzyme induction activities and gravimetric changes of the tissues. These PCDF congeners, especially 2,3,4,7,8‐penta‐CDF, were also very accumulative in the liver. Therefore, they are considered as the most important etiologic agents for the current symptoms and signs of Yusho patients.
Causal Agents of Yusho
Authors: Kunita Nobuharu , Kashimoto Takashi , Miyata Hideaki , Fukushima Shigehiko , Hori Shinjiro , Obana Hirotaka 
Published: October 2013

AbstractThrough the analysis of polychlorinated biphenyls (PCBs), polychlorinated quaterphenyls (PCQs), and polychlorinated dibenzofurans (PCDFs) retained in the blood of Japanese and Taiwanese patients who had been poisoned by ingesting contaminated cooking oils, in the blood of workers occupationally exposed to PCBs, and in the blood of unexposed individuals, it was strongly suggested that PCDFs might be the responsible compounds for the development of Yusho disease. To confirm this, animal experiments were done. The dermal signs resembling those of Yusho were observed among the cynomolgus monkeys that received a PCDF mixture consisting of PCDF components similar to those in the Yusho oils. In addition, significant thymic atrophy and decreased body weight gain were noted in the rats fed PCDFs. However, the administration of PCBs or PCQs alone failed to cause such signs in the monkeys or rats. As a result, it became clear that PCDFs were the main causative agents in the pathogenesis of Yusho disease.
Polychlorinated biphenyls, dibenzofurans, and quaterphenyls in the toxic rice‐bran oil and PCBs in the blood of patients with PCB poisoning in Taiwan
Authors: Chen Paul Hsi‐Sung , Luo Mei‐Lan , Wong Chu‐Kwan , Chen Chiou‐Jye 
Published: October 2013

AbstractA mass outbreak of poisoning occurred in central Taiwan in 1979 due to the ingestion of rice‐bran oil contaminated with polychlorinated biphenyls (PCBs). In addition to PCBs, polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls (PCQs) were also found in the contaminated oil. The levels of toxic agents in the rice‐oil samples collected from factory and school cafeterias and the families of the intoxicated patients were in the range of 53–99 ppm, 0.18–0.40 ppm, and 25–53 ppm for PCBs, PCDFs, and PCQs, respectively. Major components of PCBs and PCDFs in the toxic oil were separated and identified by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) using glass capillary columns. The most toxic PCB reported in commercial PCB preparations, 3,4,3′,4′‐tetrachlorobiphenyl, was found in the toxic oil as well as in one of the patients' blood and adipose tissue at an early stage of poisoning. The blood samples of 165 patients collected 9 to 18 months after the onset of poisoning contained 10 to 720 ppb of PCBs with a mean value of 38 ppb. One of the most toxic PCDFs, 2,3,4,7,8‐pentachlorodibenzofuran, was retained in the liver of a deceased patient. This compound could play an important role in the etiology of PCB poisoning in Taiwan.
A trial of fasting cure for PCB‐poisoned patients in Taiwan
Authors: Imamura Motoo , Tung Ta‐Cheng 
Published: October 2013

AbstractSixteen patients poisoned by ingestion of a rice oil contaminated with polychlorobiphenyls (PCBs) in Taiwan voluntarily joined a trial of fasting cure for either seven or ten days approximately 26 or 35 months after being poisoned. During fasting, mixed juice made of fresh vegetables and fruits and milk or “tohnyu,” that is, boiled soybean juice, were given on a fixed schedule. All these patients showed improvements of their symptoms and signs caused by the poisoning. Some of them enjoyed a dramatic relief of their sufferings such as severe headache, lumbago, arthralgia, pain at the sole, cough, sputa, and/or acneiform eruptions. The eruptions forming abscesses or cysts were, however, hard to cure. Thus, the fasting cure was demonstrated to be effective in the treatment of the patients. PCB concentrations in blood were rather elevated during and after the fasting.
A proportional mortality ratio study of workers in a construction equipment and diesel engine manufacturing plant
Authors: Mallin Katherine , Berkeley Lon , Young Quentin 
Published: October 2013

AbstractThe mortality of 461 workers who were employed 10 or more years in a Midwest engine and construction equipment plant was examined, using the method of proportional mortality ratios. Both state and national deaths were used as the standard population. Major exposures in this plant included solvents, cutting oils, and metal fumes and dusts. However, precise exposure data were not available. Among white males, no significant deviations from expected deaths were found. Among black males, significant excess deaths were found for all malignant neoplasms combined, for cancer of the pancreas, and for non‐Hodgkin's lymphomas. Proportional cancer mortality ratios produced similar results, although the excess of pancreatic cancer in blacks was only significant among those with 20 or more years of service. Although complete occupational histories were not available, these results may provide hypotheses for future studies of workers in heavy machinery production.
Chronic cadmium intoxication: Tissue response in an occupationally exposed patient
Authors: Garry Vincent F. , Pohlman Barbara L. , Wick Mark R. , Garvey Justine S. , Zeisler Rolf 
Published: October 2013

AbstractThis case report describes the natural history of chronic cadmium intoxication in a woman who was exposed to excessive cadmium in her occupation. We document the clinical, laboratory, and tissue response to the toxicant.
Subclinical cervico‐spino‐bulbar effects of lead: A study of short‐latency somatosensory evoked potentials in workers exposed to lead, zinc, and copper
Authors: Araki Shunichi , Murata Katsuyuki , Aono Hiroshi 
Published: October 2013

AbstractSubclinical central and peripheral nervous system dysfunction among lead‐exposed workers was studied by measuring short‐latency somatosensory evoked potentials (SSEP) and maximal motor and sensory nerve conduction velocities (MCV and SCV) following stimulation of the median nerve at the wrist. The examinations were conducted in 20 gun‐metal foundry workers exposed to lead, zinc, copper, and tin, with blood lead (BPb) concentrations of 16 to 64 μg/dl (mean, 42 μg/dl). The interpeak latency of SSEP in the cervico‐spino‐bulbar region [N9(Erb)‐N13 latency] was significantly prolonged, and the MCV and SCV in the forearm were significantly slowed. Multiple regression analysis revealed that the yield of urinary lead following challenge with calcium disodium ethylenediamine tetraacetate (CaEDTA) and packed red blood cell volume were the major factors associated with the prolongation of SSEP latency in the cervico‐spino‐bulbar region. Similarly, the interpeak latency in the upper central nervous system (N13–N20 latency) was inversely related to the zinc concentration in erythrocytes; latency up to the Erb's point [N9(Erb) latency], which reflects conduction time in a long pathway of the sensory median nerve, was inversely related to urinary zinc level; the MCV and SCV in the palm were positively related to erythrocyte zinc concentration and plasma copper concentration, respectively. These findings suggest that the subclinical neurophysiological effects of lead occur not only in peripheral nerves but also in the central nervous system. It appears that zinc antagonizes the central and peripheral neurologic dysfunction caused by lead; similarly, copper antagonizes the peripheral sensory nerve dysfunction.
Clinical findings among asbestos workers in U.S.: Influence of cigarette smoking
Authors: Lerman Yehuda , Selikoff Irving J. , Lilis Ruth , Seidman Herbert , Gelb MS Steven K. 
Published: October 2013

AbstractAll members of a large union were invited to participate in a study of potentially adverse effects of asbestos exposure. Clinical findings among 1,117 workers (90% of those eligible for examination) are presented in this study. Cough was much less common among those without a history of cigarette smoking, although duration from onset of employment did not appreciably affect the prevalence of cough among the smokers. Rhonchi present among nonsmokers were limited in extent, but were marked and diffuse among cigarette smokers. Although dyspnea was as prevalent among nonsmokers as in smokers forty years and more after onset of exposure, it was relatively uncommon and found only among smokers when examined shortly after onset of exposure. Cigarette smoking had less influence on the prevalence of rǎles among asbestos workers; both smokers and nonsmokers showed this finding when examined 30 years and more after onset of asbestos exposure. Analysis of powerhouse work experience and mask use as possible confounders indicated no difference in prevalence of these characteristics between the smokers and nonsmokers.