bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Psychological and Physiological Effects of Igusa (Juncus effusus L. var. decipiens “Suzukaze”) Scent： A Pilot Study Using Igusa Water
Authors: Goto Seiko , Hamano Hiroshi , Nakajima Taisuke , Kishida Fumi , Isa Akiko , Zennifa Fadilla , Xu Yanli , Shimizu Kuniyoshi 
Published: August 2024

Abstract

Background
Tatami mats, an integral part of traditional Japanese architecture, are renowned for their distinctive scent primarily derived from rush (Juncus effusus L. var. decipiens) or igusa in Japanese. Although the aroma of tatami is deeply ingrained in Japanese culture, its potential psychological and physiological effects remain underexplored.
Methods
This study investigated the effects of igusa scent on mood, cognitive function, and behavior. The experiment was conducted in three stages to clarify its effects; 1. on brain activity when individuals inhaled a scent released from an inhaler in a small closed room, 2. on healthy subjects’ moods in a normal living environment with a scent emitted by a diffuser, and 3. on the well-being of elderly individuals in a normal living environment using scents emitted by a diffuser. EEG monitor, visual stimuli tests, POMS mood test, 100 square calculation tests, and questionnaire were used for healthy individuals. MMSE test, DBD test, and CMAI test were used for individuals with dementia.
Results
Subsequent experiments involving healthy individuals and elderly participants in nursing homes revealed that igusa scent enhanced cognitive function, improved mood, and reduced behavioral symptoms, especially among elderly individuals with dementia.
Conclusions
The scent of igusa water demonstrated its effects regardless of preference. It can also be expected to have an effect through long-term exposure, even for those who do not perceive the scent.
Peer-led intervention for individuals with major depression: study protocol for a randomized controlled trial (SUPEERMood)
Authors: Gonzalez-Garcia Xandra , Moreno-Sancho M. Lucia , Roa-Díez Patricia , Caceres-Tejeiro Yolanda , Flowers Sarah-Louise Auvergne , Montes Concha Gómez , Bennasar-Veny Miquel , García-Toro Mauro , Yañez Aina M. 
Published: August 2024

Abstract

Background: Major Depressive Disorder (MDD) is one of the most disabling mental health problems worldwide. The Recovery Model emphasizes peer support to empower individuals with MDD, improve self-management, and patients' quality of life. Despite the demonstrated efficacy of peer-led interventions, further research is needed due to methodological limitations and variability in interventions across studies. Therefore, the objective of this trial is to evaluate the effectiveness of an adjuvant peer-led intervention for the reduction of depressive symptoms in individuals diagnosed with MDD attended in primary care mental health units.
Methods: A controlled, parallel, randomized clinical trial will be conducted. The intervention group (n=35) will receive 6 weeks of peer-led sessions based on a peer support program drive whilst supervised by nurses, while the control group (n=35) will use a mobile Health (mHealth) application for emotional wellness based on CBT for 6 weeks. Measurements will be collected at baseline, at 6 weeks, at 6 and 12 months after the intervention to evaluate post-intervention effects. The primary outcome is the reduction of depressive symptoms through the Beck Depression Inventory (BDI-II) after the intervention. Secondary outcomes will involve measures such as adherence to psychiatric treatment, quality of life, adherence to mediterranean diet, alcohol consumption and physical activity.
Discussion: We hypothesize that this peer-led intervention, in contrast to the mHealth, will show improvement in BDI-II score reduction of 6 points after six weeks, 6 and 12 months. Standardized peer-led programs can benefit patients and professionals in terms of efficacy and feasibility of clinical treatment of depression, healthy habits, self-care and quality of life. In addition, they can provide recovery and relapse reduction, improved psychosocial support, minimization of intensive care use, and support for patient autonomy through self-management.
Trial registration: The trial protocol is prospectively registered with ClinicalTrials.gov under protocol registration number NCT06398561. Date of registration: May 01, 2024. Recruitment is ongoing.
The explanation of electrical properties changes under NH3 and H2 containing atmospheres in risen temperatures of ceria- and zirconia-based solid electrolytes by means of electrochemical impedance spectroscopy
Authors: Dziubaniuk Małgorzata 
Published: August 2024

Abstract

In the presented research, commercial powders of nominal compositions: Ce0.8Gd0.2O1.9, Sc0.1Ce0.01Zr0.89O1.95, Sc0.09Yb0.01Zr0.9O1.95 structural and electrochemical properties were investigated. The X-ray diffraction of the specimens at room temperature showed a cubic phase. Electrical properties studies over a wide range of frequencies (0.1 Hz to 32 MHz) and temperature (200–600 °C) were analyzed using impedance spectroscopic technique in different atmospheres (synthetic air, 3000 ppm NH3 in argon, 10% H2 in argon). The impedance plane plot shows semicircle arcs at different temperatures and electrical equivalent circuit have been proposed to analyze the impedance results. Basing on comparison of the spectra in different atmospheres the reactions on the three-phase boundaries were proposed as well as the conduction mechanisms of the electrolytes were described. The material based on ceria is mixed ionic-electronic conductor, while in zirconia-based materials electrical conduction is realized by oxygen ion carriers. The electrochemical properties of the powders were compared from the applicative point of view as a candidate for element in fuel cells and gas sensors.
Human Papillomavirus Vaccine Uptake among Adolescent Survivors of Hematopoietic Stem Cell Transplant
Authors: Morrison Aimee , Myers Kasiani , Streich-Tilles Tara 
Published: August 2024

Abstract

Purpose
To characterize the rate of human papillomavirus (HPV) vaccine uptake in the adolescents after hematopoietic stem cell transplant (HSCT).
Methods
This retrospective study evaluated the vaccine history of adolescent HSCT patients ≥ 11 years of age transplanted between 2015 and 2022 at a tertiary care medical center. Logistic regression was used to examine bivariate associations between HPV vaccine uptake and covariates including demographic factors, indication for and type of HSCT, receipt of HPV vaccine prior to transplant, and receipt of other vaccines after transplant.
Results
Among 119 (n = 53 female; n = 66 male) eligible patients, 66 (55.5%) received ≥ one dose of the HPV vaccine after HSCT. Among those who initiated vaccination, 45/66 (68.2%) completed two or more doses. Of 69 patients who were eligible to receive the vaccine prior to HSCT, 19/36 (52%) were vaccinated both before and after HSCT, compared to 14/33 (42%) who did not receive the vaccine before HSCT but chose to be vaccinated after HSCT. No statistically significant difference was identified between those who did and did not initiate HPV vaccination after HSCT among covariates examined.
Conclusions
Rate of HPV vaccine uptake after HSCT was lower compared to the general U.S. adolescent population and lower than the rate of other recommended vaccines. Receiving HPV vaccine prior to HSCT was not associated with HPV re-uptake after HSCT.
Implications for Cancer Survivors: HPV vaccination continues to be suboptimal in HSCT survivorship and should be a targeted goal for improvement in preventing secondary malignancy in this high-risk population.
Inflammation patterns in early postoperative cholangitis predict long-term outcomes in biliary atresia: A potential role of non-suppurative cholangitis
Authors: Harumatsu Toshio , Muraji Toshihiro , Masuya Ryuta , Tsuruno Yudai , Iwamoto Yumiko , Ogata Masato , Takada Lynne , Kedoin Chihiro , Nagano Ayaka , Murakami Masakazu , Sugita Koshiro , Yano Keisuke , Onishi Shun , Kawano Takafumi , Muto Mitsuru , Kaji Tatsuru , Ieiri Satoshi 
Published: August 2024

Abstract

Purpose
Frequent postoperative cholangitis in biliary atresia (BA) affects the long-term native liver survival. This study assessed the characteristics of early cholangitis and their influence on the prognosis.
Methods
Forty-three patients with BA who underwent surgery between 2000 and 2020 were analyzed for routine inflammatory markers. Early cholangitis characteristics were compared between native liver survivor (NLS) and living donor liver transplant (LDLT) patients.
Results
Among the 43 patients, 30 (69.8%) experienced 130 episodes of cholangitis. In the area under the receiver operating characteristics curve (AUROC) analysis, the cutoff value of the total cholangitis episodes was 3, with an area under the AUROC curve of 0.695 (95% confidence interval: 0.522–0.868). Before 3 years old, 113 episodes (86.9%) of cholangitis were observed. The white blood cell, C-reactive protein, and alanine aminotransferase values at cholangitis onset did not markedly differ between the LDLT and NLS groups. Conversely, the neutrophil-to-lymphocyte ratio in the NLS group was significantly lower than in the LDLT group (0.85 vs. 1.63, p < 0.001).
Conclusions
Cholangitis in the NLS group was lymphocyte-dominant and atypical in its pathogenesis. Lymphocyte-dominant cholangitis is non-suppurative, and future research should clarify its pathogenesis to improve the treatment and prognosis of BA.
An ultrasound-guided supraclavicular approach for tunneled central venous catheter insertion can be safely performed by junior residents
Authors: Iwamoto Yumiko , Onishi Shun , Sugita Koshiro , Nakame Kazuhiko , Kaji Tatsuru , Yano Keisuke , Ogata Masato , Takada Lynne , Kedoin Chihiro , Nagano Ayaka , Murakami Masakazu , Harumatsu Toshio , Yamada Koji , Yamada Waka , Masuya Ryuta , Kawano Takafumi , Muto Mitsuru , Ieiri Satoshi 
Published: August 2024

Abstract

Purpose
Ultrasound-guided supraclavicular catheterization (UGSC) of the brachiocephalic vein (BCV) for long-term tunneled central venous catheter (tCVC) insertion may be safer than the internal jugular vein approach due to its superior field of view. We examined the clinical outcomes of tCVC insertions performed by junior residents through UGSC of the BCV.
Patients and Methods:
From January 2018 to December 2023, we assessed clinical outcomes and compared the experience levels of surgeons conducting tCVC insertions. Surgeons were categorized into three groups: junior residency (JR), senior residency (SR), and board-certified pediatric surgeons (BCPS).
Results
177 tCVC insertions were done on 146 patients. Intraoperative complications included 6 cases of arterial puncture, 1 case of pneumothorax, 1 case of over insertion of catheter tip, and 1 case of suspected hemothorax. Distribution across groups was as follows: 28 cases (15.8%) in JR group, 92 (52.0%) in SR group, and 57 (32.2%) in BCPS group. Although the JR group exhibited longer operation times than the BCPS group, no significant differences in intraoperative complications were noted.
Conclusion
Junior residents can safely perform UGSC for tCVC insertion. However, careful consideration of complications such as arterial or thoracic puncture is essential, and case selection should be based on experience.
Rheumatoid Arthritis and Risk of Nontuberculous Mycobacterial Pulmonary Disease: A Nationwide Longitudinal Cohort Study
Authors: Yang Bumhee , Han Kyungdo , Jung Jin-Hyung , Jung Wonyoung , Kim Bo-Guen , Eun Yeonghee , Kim Hyungjin , Shin Dong Wook , Lee Hyun 
Published: August 2024

Abstract

Background
In this study, we aimed to evaluate the risk of incident nontuberculous mycobacteria pulmonary disease (NTM-PD) in subjects with rheumatoid arthritis (RA) versus age- and sex-matched controls, while focusing on the impact of RA serologic status on this association.
Methods
From the Korean National Health Insurance Service data from 2010 to 2017, we identified 60,315 participants aged ≥ 20 years with RA and 301,575 without RA who were age- and sex-matched 1:5. The participants were followed up from 1 year after RA diagnosis (or the corresponding index date for matched controls) to the date of NTM-PD diagnosis, censored date, or December 31, 2019, whichever occurred first.
Results
During a median 4.5 (interquartile range, 2.6–6.4)-year follow-up, NTM-PD occurred in 0.23% and 0.06% of the RA and matched cohort (incidence: 0.54 and 0.14 per 1,000 person-years), respectively. Compared to controls, participants with RA had a 3.11-fold (95% confidence interval [CI]: 2.50–3.88) higher risk of NTM-PD. In the subgroup analysis stratified by seropositivity, seropositive patients with RA had a 3.77-fold (95% CI: 3.00–4.73) higher risk of NTM-PD than controls whereas participants with seronegative RA did not have a significantly higher risk (adjusted hazard ratio: 1.18, 95% CI: 0.68–2.04). Stratified analyses showed a more prominent association of RA with NTM-PD in males, alcohol drinkers, and obese individuals (p < 0.05).
Conclusion
The risk of incident NTM-PD was approximately 3-fold higher in participants with RA than in matched controls, although the association was significant only for patients with seropositive RA.
Impact of mixing and shaking on mRNA-LNP drug product quality characteristics
Authors: Matthessen Roman , Pottelberge Robbe Van , Goffin Ben , De Winter Giel 
Published: August 2024

Abstract

Since the COVID-19 pandemic, the interest in RNA - lipid nanoparticle (LNP) based drug products has increased drastically. While one RNA-LNP drug product, Onpattro, was already on the market in 2018, high volume manufacturing was only initiated end of 2020 with the approval of the mRNA-LNP vaccines, Comirnaty and Spikevax. As such, deep product knowledge for RNA-LNPs is continuously increasing. In this article the effect of large-scale mixing and lab-scale shaking on mRNA-LNP drug product quality characteristics is investigated. It is shown that mixing and shaking can have a profound impact on both LNP size distribution and mRNA encapsulation, suggesting a direct correlation between both quality characteristics, and further supported by a proposed underlying mechanism. An in-depth investigation of different drug product (DP) presentations reveals a consistent effect of headspace volume and LNP content on the shaking stress sensitivity. Results reported in this study are of utter importance for both small- and large-scale manufacturers but also for care givers and patients using these products.
Impact of Surgical Revascularization on Regression of Enlarged Perivascular Spaces in Adult Moyamoya Disease
Authors: Yamamoto Shusuke , Akai Takuya , Kashiwazaki Daina , Maruyama Kunitaka , Hori Emiko , Akioka Naoki , Noguchi Kyo , Kuroda Satoshi 
Published: August 2024

Abstract

Objective
Previous studies have suggested that enlarged perivascular spaces (EPVSs) are potential radiological markers of cerebral ischemia in moyamoya disease (MMD). However, serial changes in EPVSs after surgical revascularization have not yet been clarified. In the present study, we evaluated the change of EPVSs after surgical revascularization in adult patients with MMD.
Methods
This was a single-center study. We counted the EPVSs in the basal ganglia (BG) and centrum semiovale (CSO) in each hemisphere on T2-weighted MRI performed upon admission. EPVSs were also quantified three months and two years after combined bypass surgery in surgically treated patients and compared with the number of EPVSs before surgery. We performed multivariate logistic regression analysis to identify the clinical and radiological factors associated with the number of EPVSs.
Results
This study included 120 hemispheres of 65 adults with MMD. Older age (P = 0.04) and hypertension (P = 0.04) were significantly associated with a larger baseline number of EPVSs in the BG. Older age (P < 0.01), posterior cerebral artery (PCA) involvement (P < 0.01), and cerebral blood flow (CBF) impairment (P = 0.02) were significantly associated with a large number of EPVSs in the CSO. The number of EPVSs only in the CSO markedly decreased at three months and two years after surgery compared with that before surgery (P < 0.01).
Conclusions
The number of EPVSs in the CSO was closely associated with age, PCA involvement, and CBF impairment in adult patients with MMD, which remarkably regressed after surgical revascularization. EPVSs are reversible radiological markers reflecting impaired cerebral hemodynamics in adult patients with MMD.
Comprehensive Assessment of Cardiovascular Risk Factors among Long-Haul Truck Drivers in South Brazil and its Impact on 3-year follow-up of Cardiovascular Events
Authors: Sangaleti Carine Teles , Brügge Joelson , Santos Jordana Canestraro , Gonçalves Wyndson Ribeiro , Trincaus Maria Regiane , Baratieri Tatiane , Lentsck Maicon Henrique , Pelazza Bruno Bordin , Silveira João Vicente , Irigoyen Maria Claudia , Consolim-Colombo Fernanda 
Published: August 2024

Abstract

Background
Cardiovascular diseases are a significant concern among truck drivers due to their profession's nature, involving long hours of sedentary work and exposure to various risk factors. Prevalence of risk factors associated with cardiovascular health in long-haul truck drivers and their impact on incidence of cardiovascular events are less studied.
Methods
A prospective cohort study was conducted among long-haul truck drivers traveling on BR 277, a major federal highway in Brazil. Truck drivers aged 18 years and above were recruited from four strategically selected locations along the route and were sequentially invited to participate while waiting to load and unload cargo. Clinical evaluations, including socio-demographic information, occupational factors, chronic disease history, medication use, lifestyle habits, and screening for obstructive sleep apnea, were performed. Physical measurements, blood glucose levels, lipid profile, ultrasensitive protein C-reactive, ankle-brachial index, left ventricular hypertrophy and heart rate variability were assessed. Participants were followed up for three years to detect the incidence of major cardiovascular events.
Results
The study revealed that obesity, diabetes and smoking were highly prevalent among long-haul truck drivers. A significant proportion of drivers met the criteria for metabolic syndrome and had a high-risk score for cardiovascular events. Moreover, subclinical inflammation, vascular stiffness, left ventricular overload and increased cardiac sympathetic modulation were also highly prevalent. The presence of multiple risk factors and medical conditions was associated with an increased likelihood of a major cardiovascular event.
Conclusion
The findings emphasize the need for targeted interventions to improve the cardiovascular health of truck drivers and promote roadway safety.
Modification on PBS using epoxy-functionalized core-shell starch particles
Authors: Liu Qiang , Ren Liang , Li Xinyang , Sui Xinyan , Shen Yunda , Wang Y.B. , Li Y.Q , Zhang Mingyao 
Published: August 2024

Abstract

Polybutylene succinate (PBS) is an aliphatic linear polyester that is known for its excellent biodegradability and biocompatibility, making it one of the most promising application polymers. However, its disadvantages of poor toughness, low thermostability, and high crystallinity limit its large-scale commercial applications. In this article, a novel epoxy-functionalized core-shell starch particle (CSP-GMA) is successfully synthesized by virtue of soap-free emulsion polymerization, which consists of a "hard" starch (St) core and a "soft" ethyl acrylate (EA) shell grafted with glycidyl methacrylate (GMA). A binary blend of biodegradable polymers is prepared via a melt blend process with CSP-GMA as a core-shell particle modifier and PBS as a polymer matrix. The mechanical properties, thermal behavior, crystallization properties, stability and microscopic morphology of PBS/CSP-GMA blends are thoroughly studied. The incorporation of 20 wt% CSP-GMA into the PBS blend promotes an increase in the impact strength by 55% and the elongation at break by 173% higher than that of pure PBS respectively, which indicates that our work proposes an efficient strategy for fabricating PBS blends with good comprehensive properties and low cost. The DSC testing shows that the crystallinity of PBS blend is reduced in comparison to PBS, while the crystallization temperature is also decreased, confirming that CSP-GMA can facilitate the crystallization of PBS. The SEM observation reveals that owing to the compatibility arising between two phases interface due to the presence of epoxy group on core-shell starch particle surface, CSP-GMA is better dispersed in the PBS matrix, resulting in the improvement for performance of PBS blends.
Concurrent Acute Cystitis, Pancolitis, and Tubo-Ovarian Abscess Following Laparoscopic Ovarian Cystectomy: A Case Report
Authors: AlHabil Yazan , Owda Anas N. , Zaid Basil J. , Hameedi Seema , Saadeddin Liza , Awad Mohammad A.A. 
Published: August 2024

Abstract

Background
Inadequate surgical interventions can lead to serious complications such as tubo-ovarian abscesses in the upper female genital system, often resulting from untreated pelvic inflammatory disease. Pelvic inflammatory disease, caused by infections like Chlamydia trachomatis and Neisseria gonorrhoeae, leads to scarring and adhesions in the reproductive organs, with common risk factors including intrauterine device use and multiple sexual partners. Pelvic inflammatory disease primarily affects sexually active young women and can manifest with varied symptoms, potentially leading to complications like ectopic pregnancy, infertility, and chronic pelvic pain if untreated.
Case presentation
This case report presents a unique scenario involving a 17-year-old sexually inactive female who experienced concurrent tubo-ovarian abscess, acute cystitis, and pancolitis following laparoscopic ovarian cystectomy. Pelvic inflammatory disease and its complications are well-documented, but the simultaneous occurrence of acute cystitis and pancolitis in this context is unprecedented in the medical literature. The patient’s presentation, clinical course, and management are detailed, highlighting the importance of considering diverse and severe complications in individuals with a history of gynecological surgeries.
Conclusions
Our case report highlights the need for healthcare professionals to remain vigilant for atypical presentations of gynecological complications and emphasizes the value of interdisciplinary collaboration for optimal patient care. We encourage further research and awareness to enhance understanding and recognition of complex clinical scenarios associated with gynecological procedures.