bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN ARSITEKTUR PERILAKU PADA FASILITAS SEKOLAH LUAR BIASA BHAKTI WIYATA SURABAYA
Authors: Izzulhaq Thariq , Winasih Sri Suryani Yuprapti 
Published: August 2024

Pembelajaran pendidikan bagi siswa penyandang disabilitas di Indonesia mendapatkan perhatian yang kurang. Menurut Pendiri Lembaga Pemberdayaan Tunanetra (LPT), Tutus Setiawan menilai fasilitas untuk pembelajaran pendidikan Inklusi perlu perbaikan. Dengan adanya fasilitas yang menunjang untuk anak berkebutuhan khusus, akan dapat membantu lingkup pembelajaran yang sama dengan sekolah umum dan membantu meningkatkan kesadaran masyarakat sekitar. Fasilitas menjadi permasalah utama dalam pembelajar untuk anak berkebutuhan khusus. Untuk memenuhi kebutuhan desain, maka digunakan pendekatan perilaku. Arsitektur perilaku dirasa cocok dalam penerapan, guna membuat penyandang disabilitas mendapat rasa nyaman terhadap fasilitas yang digunakan. Aspek kebutuhan fasilitas terhadap penyandang disabilitas merupakan hal penting dari segi pembelajaran. Hal ini sudah tertulis pada UUD Pasal 31 ayat (1) “Tiap-tiap warga negara berhak mendapat pengajaran”. Warga negara tersebut termasuk dengan anak berkebutuhan dengan fasilitas yang memadai. Hal ini dapat meningkatkan pendidikan untuk anak berkebutuhan khusus. Metode pada penelitian ini menggunakan metode deskriptif kualitatif dengan cara melakukan kunjungan langsung dan pengamatan secara langsung pada objek, selain itu terdapat sesi wawancara dengan pemilik bangunan SLB Bhakti Wiyata. Hal ini untuk memahami metode pembelajaran di sekolah dari segi perilaku maupun suasana ruangan. Penelitian ini bertujuan untuk mendapatkan pemahaman arsitektur perilaku yang pada bangunan SLB Bhakti Wiyata dari segi fasilitas untuk pembelajaran anak berkebutuhan khusus.
Library user digital profiling: The structural and functional approach. (Part II)
Authors: Kapterev A. I. 
Published: August 2024

The article continues on the topic raised in the Part I. In the Part I, the model library user digital profile (DP) is introduced, and the options for its structuring and application are discussed. The following issues are examined: a) user digital profile structure with specifying the layers, namely, subject, object, domain, communications, – and b) layer function – identification, clusterization, filtration, or collaboration. While the DP subject and object layers and the dominating factors were discussed in the Part I, the Part II details the DP domain and communications layers which would enable to meet library user information needs proactively.The article is prepared under the Government Order to RNPLS&T No. 1021062311368-2-5.8.3 “Development of e-librarianship as a scientific and academic discipline in the circumstances of transforming library collections, reference and bibliographic and document services in the digital environment” (FNEG-2022-0004) for 2022-2024.
Penghentian Perkara Berdasarkan Restorative Justice Dalam Perkara Tindak Pidana Pencurian Di Kota Sorong
Authors: Ramli Irfan , Hidaya Wahab Aznul , Muharuddin Muharuddin 
Published: August 2024

Pokok permasalahan ini adalah mengetahui bagaimana proses penanganan restorative justice pada tindak pidana pencurian yang ada pada kantor kejaksaan negeri sorong. Penelitian ini menggunakan metode penelitian emperis dengan memadukan daya yang ada di lapangan dan yang berkaitan dengan apa yang akan dibahas skripsi ini. Hasil penelitian dalam penulisan skripsi adalah menjelaskan atau membahas terkait tindak pidana pencurian yang dapat diselesaikan dengan proses restorative justice yang ada pada kantor kejaksaan negeri sorong yang mana dari proses P-21 dari kepolisian hingga tahap pemeriksaan tersangka, korban, jaksa, kepala kejaksaan (kajari), Kepala kejaksaan tinggi (kajati), tetua adat atau yang dituakan, sehingga proses pemeriksaan dari bapak jaksa agung tindak pidana umum (jampidum), sampai proses pembahasan tersangka. Kesimpulan dari penelitian ini adalah dengan adanya pendekatan penyelesaian perkara restorative justice untuk berjuang mendorong seseorang yang melakukan pidana tidak menjalani proses pidana melalui musyawarah secara bersama diharapkan dapat memberikan sebuah solusi dan alternatif penyelesaian perkara tindak pidana.

Kata Kunci : Penghentian Perkara; Restorative Justice; Tindak Pidana
Changes in epinephrine dispensings and allergy hospitalisations in Sweden in the years following the removal of autoinjector co-payments
Authors: Ahlstedt Staffan , Bergström Anna , Nilsson Lennart , Kivistö Juho E , Protudjer Jennifer L P 
Published: August 2024

IntroductionTo understand any possible healthcare system benefits and changes of behavior for the patients with the change in prescription co-payment in Sweden we aimed to provide an update on the trends of EAI dispensings and hospitalizations for the Swedish paediatric population (ages 0–19 years), from 2018 to 2022, including by sex and geographic region.MethodsUsing publically-available, population-level aggregate data from Sweden's National Board of Health and Welfare, we extracted information on annual epinephrine (ATC C01CA24) dispensings per 1,000 inhabitants from 2018 to 2023, overall, as well as stratified by sex, age groups and geographic region; and on inpatient stays 2018–2022 (ICD-10 code T78), anaphylaxis and other allergic reactions, per 100,000 individuals. We compared these estimates to those for adults ages 18 + years, for whom prescription co-payments remained in place.ResultsEAI dispensings remained stable for children and adults across the study period, with the exception of statistically significant decreases amongst dispensings for children across all ages in 2021 (6.65/1,000) and 2022 (7.37/1,000), compared to 2018 (8.63/1,000) (each year p = 0.03 compared to 2018 dispensings). National EAI dispensings did not statistically significantly differ from 2018 (8.63/1,000) to 2023 (6.70/1,000) amongst children. EAI dispensings for children ages 5 + years consistently exceed dispensings for adults per 1,000 inhabitants; only children aged 0–4 years had proportionately fewer dispensings. Children ages 0–4 years tended to be hospitalised more often than older children, albeit these differences were not statistically significant (all p &gt; 0.97).ConclusionSubsequent to the removal of out-of-pocket costs for EAI, dispensings did not increase for children, although more EAI were dispensed to children from age 5 years, compared to younger children. Allergy-related hospitalisations were highest amongst children ages 0–4, lower amongst children ages 5–14 years, and again higher amongst those ages 15–19 years.
The effects of antimicrobial peptides buCaTHL4B and Im-4 on infectious root canal biofilms
Authors: Hu Ziqiu , Ren Haixia , Min Yifan , Li Yixin , Zhang Yuyuan , Mao Min , Leng Weidong , Xia Lingyun 
Published: August 2024

PurposeThe primary cause of pulp and periapical diseases is the invasion of bacteria into the root canal, which results from the continuous destruction of dental hard tissues. Effective management of infections during root canal therapy necessitates effectively irrigation. This study aims to investigate the effects of two antimicrobial peptides (AMPs), buCaTHL4B and Im-4, on root canal biofilms in vitro.MethodsTwo-species biofilms (Enterococcus faecalis and Fusobacterium nucleatum) were selected and anaerobically cultivated. The following treatments were applied: 10 μg/mL buCaTHL4B, 10 μg/mL Im-4, 5 μg/mL buCaTHL4B, 5 μg/mL Im-4, 1 μg/mL buCaTHL4B, 1 μg/mL Im-4, 1% NaOCl, and sterile water. Each group was treated for 3 min. Subsequently, the two strains were co-cultured with 10 μg/mL buCaTHL4B, 10 μg/mL Im-4, 1% NaOCl, and sterile water for 24, 48, and 72 h. The biofilms were examined using confocal laser scanning microscopy (CLSM) with fluorescent staining, and the percentages of dead bacteria were calculated. Quantitative real-time PCR (qRT-PCR) was employed to assess the variations in bacterial proportions during biofilm formation.ResultsCompared to 1% NaOCl, 10 μg/mL buCaTHL4B or Im-4 exhibited significantly greater bactericidal effects on the two-species biofilms (p &lt; 0.05), leading to their selection for subsequent experiments. Over a 48-hour period, 10 μg/mL Im-4 demonstrated a stronger antibiofilm effect than buCaTHL4B (p &lt; 0.05). Following a 24-hour biofilm formation period, the proportion of F. nucleatum decreased while the proportion of E. faecalis increased in the sterile water group. In the buCaTHL4B and 1% NaOCl groups, the proportion of F. nucleatum was lower than that of E. faecalis (p &lt; 0.05), whereas in the Im-4 group, the proportion of F. nucleatum was higher than that of E. faecalis (p &lt; 0.05). The proportions of bacteria in the two AMPs groups gradually stabilized after 24 h of treatment.ConclusionbuCaTHL4B and Im-4 exhibited remarkable antibacterial and anti-biofilm capabilities against pathogenic root canal biofilms in vitro, indicating their potential as promising additives to optimize the effectiveness of root canal treatment as alternative irrigants.
Epidemiological characteristics of mycoplasma pneumoniae in hospitalized children before, during, and after COVID-19 pandemic restrictions in Chongqing, China
Authors: You Jingyi , Zhang Linghuan , Chen Wei , Wu Qifan , Zhang Dayong , Luo Zhengxiu , Fu Zhou 
Published: August 2024

BackgroundMycoplasma pneumoniae (MP) is a significant cause of community-acquired pneumonia with high macrolide resistance rates. Various COVID-19 pandemic restrictions have impacted the prevalence of MP.ObjectiveTo assess the changes in the pattern of MP infections among children before, during, and after the COVID-19 pandemic.MethodsA total of 36685 enrolled patients, aged 0-18 years, diagnosed with pneumonia and admitted to Children’s Hospital of Chongqing Medical University from January 2019 to December 2023, were retrospectively reviewed in this study. The epidemiological characteristics of pediatric MP infection were analyzed.ResultsAmong 36685 patients, 7610 (20.74%) tested positive for MP. The highest positive rate was observed among children aged over 6 years (55.06%). There was no gender disparity in MP infection across the three phases of the COVID-19 pandemic. Hospital stays were longest for children during the COVID-19 pandemic (P &lt;0.001). MP infection was most prevalent in the summer (29.64%). The lowest positive rate was observed during the pandemic, with the highest rate found after easing the measures across all age groups (P &lt;0.001). There was a surge in the positive rate of MP in the third year after the COVID-19 pandemic. Regression analyses demonstrated a shift in the age range susceptible to MP infection, with children aged 3.8 to 13.5 years post-pandemic compared to the pre-pandemic range of 5.3 to 15.5 years old. Additionally, the average macrolide resistance rate was 79.84%. We observed a higher resistance rate during the pandemic than in the pre- and post-pandemic phases (P &lt;0.001).ConclusionThe restrictive measures implemented during the COVID-19 pandemic have influenced the spread of MP to some extent and altered demographic and clinical characteristics, such as age, age group, season, length of stay, and macrolide resistance. We recommend continuous surveillance of the evolving epidemiological characteristics of MP infection in the post-pandemic period when restrictions are no longer necessary.
Potential treatment of glutathione in bullfrogs with abnormal hepatic lipid metabolism revealed by hepatic lipid metabolism and serum metabolomics analysis
Authors: Su Zehui , Gao Fu , Shu Rui , Cai Kai , Fang Shugaung , Lei Xiaoting , Li Dan , Hu Kun 
Published: August 2024

IntroductionWith the continuous growth of bullfrog supply, it has become an important aquaculture species. Due to the lack of actionable industry standards and regulation, the misuse of anti-disease drugs and abnormal liver lipid metabolism in bullfrogs have become a major obstacle to the development of bullfrog aquaculture industry. Glutathione is a natural tripeptide that can be synthesized intracellularly, and its physiological functions mainly include the treatment of liver diseases, antioxidant, detoxification, anti-tumor, enhancement of immunity, and delaying aging.MethodsIn this study, the therapeutic effect of glutathione on bullfrogs with abnormal liver lipid metabolism was revealed from hepatic lipid metabolism and serum metabolomics analysis. The survival rate, liver histomorphology, serum antioxidant enzyme activity, liver lipase activity and serum metabolomics, liver metabolomics were studied and analyzed by feeding the bullfrogs with abnormal lipid metabolism with glutathione for 20 days in the NC, FI and GSH groups.ResultsThe results of the study showed that glutathione was able to repair the liver and improve the survival rate of bullfrogs with abnormal lipid metabolism; the activity of serum SOD enzymes was significantly increased; the activities of ACP and AKP were significantly decreased; the activities of HDL-C and T-CHO were significantly increased; and the activities of LDL-C, TBA, and TG were significantly decreased in the liver; the contents of metabolites, such as PC, PS, and PE were significantly up-regulated, and the levels of up-regulated Autophagy - other, Necroptosis and ErbB signaling pathway, and down-regulated Sphingolipid metabolism, D-Amino acid metabolism metabolic pathway, to some extent The metabolic pathways of Sphingolipid metabolism and D-Amino acid metabolism were down-regulated to alleviate the disorders of glycerophospholipid and amino acid metabolism to a certain extent, thus alleviating the abnormalities of liver lipid metabolism.DiscussionThe results showed that glutathione could effectively treat the liver lipid metabolism disorder of bullfrogs, promote the growth and development of bullfrogs, repair the liver function, reduce the inflammation, and promote the healthy and green development of bullfrog industry.
Reducing isolation for educators through ECHO virtual communities of practice
Authors: Dickson Elizabeth , Lardier David T. , Verdezoto Carolina S. , Hackett Janna M. 
Published: August 2024

IntroductionStudents in U.S. rural schools experience lower educational outcomes than their urban peers related to social determinants of health such as under resourced schools, shortages of qualified teachers and staff, and high poverty levels. Geographic, social, or professional isolation in rural communities can compound these disparities by contributing to high turnover of educators and staff. Virtual communities of practice (VCoPs) can address the needs of individuals in remote and rural communities. However, it is critical to understand if VCoPs meet rural school staff needs to support their students. Wenger’s Community of Practice (CoP) framework and the Project ECHO model for VCoPs guided this descriptive, qualitative arm of our study to explore experiences of school staff participating in VCoPs through Project ECHO.MethodsThirteen ECHO for Education participants joined virtual focus groups to discuss their experiences and perspectives of VCoPs. Interview transcripts were inductively coded using the CoP framework with enhanced rigor through audit trails and member checking.ResultsFour predominant themes emerged from the interviews: 1) belonging/connected with others; 2) reduced sense of isolation; 3) exchange of new ideas/knowledge; and 4) sense of collaboration. Participants described how the VCoP they participated in resulted in positive professional and personal experiences including the support offered in context of working in rural schools during the COVID 19 pandemic.DiscussionVCoPs can establish supportive professional networks for rural school staff working with students in under-resourced settings. Our theoretically-grounded results substantiate VCoP development as a systems-level approach to facilitate professional collaboration, mitigate staff turnover, diminish professional isolation, and support students in rural communities.
Oncocytic cell carcinoma of the thyroid with TERT promoter mutation presenting as asphyxia in an elderly: a case report
Authors: Wang Xiqian , Liu Yingao , Chen Lijie , Zhang Jie , Jiang Ruoyu , Zhang Lei , Yan Han , Zhang Jie 
Published: August 2024

IntroductionThe prevalence of thyroid nodules and malignancies in the elderly is a growing concern. Thyroid nodules in this population have unique characteristics, requiring careful treatment strategies that balance risks and benefits. Oncocytic carcinoma of the thyroid (OCA) is a rare, aggressive subtype with diagnostic challenges.MethodsThis case features an 84-year-old patient who presented with a neck mass and symptoms of asphyxia. Clinical evaluation, imaging studies, and biopsy were conducted to assess the nature of the thyroid lesion. Molecular testing, including genetic analysis, was performed to identify specific mutations associated with OCA and guide treatment decisions.ResultsThe patient was diagnosed with oncocytic carcinoma of the thyroid. The molecular testing revealed specific genetic mutations indicative of OCA, confirming the diagnosis. The presence of these mutations guided the treatment plan, emphasizing the importance of molecular diagnostics in managing thyroid malignancies, especially in the elderly.DiscussionThis case illustrates the complexities of diagnosing and treating thyroid malignancies in the elderly. Biopsy and molecular testing provided diagnostic accuracy and informed treatment. Individualized approaches are essential for better outcomes, especially in aggressive subtypes, balancing the risks and benefits of intervention.
Incidence of bronchiectasis in patients with acromegaly: a cohort study
Authors: Gil Hyun-Il , Han Kyungdo , Hong Sangmo , Park Cheol-Young 
Published: August 2024

ObjectiveAssociations between acromegaly and several respiratory diseases, such as obstructive lung disease or sleep apnea, have been suggested, but the relationship between bronchiectasis and acromegaly is unclear. We investigated whether acromegaly is related to the development of bronchiectasis.Materials and methodsUsing the Korean National Health Insurance System database between 2006 and 2016, we studied the relationship between acromegaly and bronchiectasis in patients with acromegaly (n=2593) and controls (1:5 age- and sex-matched subjects without acromegaly, n=12965) with a mean follow-up period of 8.9 years. Cox proportional hazards regression analysis was used to assess the risk of bronchiectasis in patients with acromegaly compared with controls after adjusting for age, sex, household income, place, type 2 diabetes, hypertension, and dyslipidemia.ResultsThe mean age of the participants was 47.65 years, and male subjects comprised 45.62% of the cohort. The incidence rate of bronchiectasis in patients with acromegaly was 3.64 per 1,000 person-years and was significantly higher than that in controls (2.47 per 1,000 person-years) (log-rank test p = 0.002). In multivariable Cox proportional hazards regression modeling, the risk of bronchiectasis was significantly higher in patients with acromegaly than that in controls (HR: 1.49; 95% CI: 1.15–1.94, p = 0.0025) after adjusting for age, sex, household income, place, type 2 diabetes, hypertension, and dyslipidemia.ConclusionsOur results suggest that acromegaly may be associated with bronchiectasis.
Global research trends and hotspots of oxidative stress in diabetic retinopathy (2000-2024)
Authors: Du Kejie , Liu Yichong , Zhao Xintong , Wang Haowen , Wan Xiaomei , Sun Xiaoyan , Luo Wenjuan 
Published: August 2024

IntroductionOxidative stress has been identified as a major contributor to the pathogenesis of DR, and many diagnostic and therapeutic strategies have been developed to target oxidative stress. Our aim was to understand the contribution of the country of origin of the publication, the institution, the authors, and the collaborative relationship between them.MethodsWe performed a bibliometric analysis to summarize and explore the research hotspots and trends of oxidative stress in the DR.ResultsWe observe an upward trend in the number of posts on related topics from year to year. Expanding on this, Queens University Belfast is the most influential research institution. Current research hotspots and trends focus on the mechanism of autophagy and NLRP3 inflammasome's role in oxidative stress in DR.DiscussionWe conducted a multi-dimensional analysis of the research status of oxidative stress in diabetic retinopathy through bibliometric analysis, and proposed possible future research trends and hotspots.
Projected distribution and dispersal patterns of prevalent ticks and tick-borne pathogens in the Sanjiangyuan area of Qinghai province, China, under intense climatic conditions
Authors: Xu Luyao , Guo Yunhai , Yang Limin , Li Zengkui , Kang Ming , Han Xiaoling , Chen Changjiang , He Shunfu , Hu Xiaoyu , He Yongcai , Wang Yuezhong , Li Zhongyu , Chen Jiyong , Geng Pengcheng , Chen Qiang , Jiang Shuo , Ma Jinghua , Zhang Xiao , Tai Ximei , Li Ying 
Published: August 2024

Introduction: The Maximum Entropy models (MaxEnt) is commonly employed for early detection of disease transmission, particularly effective in assessing the risk zones and intensity of tick-borne disease transmission based on climatic factors.Methods: Utilizing the diversity data of common ticks in Qinghai, along with surveillance statistics tick-borne pathogens of ticks and epidemiological information, we have charted and predicted the prevalence of tick and tick-borne pathogens across Qinghai province.Results and Discussion: The findings indicate that the pivotal environmental factors influencing the distribution of ticks and tick-borne pathogens include land use and land cover (Lucc), elevation (Elev), annual precipitation (Bio12) and annual mean temperature (Bio1). Notably, for Dermacentor nuttalli, the significant environmental factors accounted for 35.2% for Lucc, 24.7% for Elev and 18.6% for Bio12. In the case of Dermacentor silvaru, the pivotal factors contributed 33.2% for Lucc, 23.7% for Elev and 22.6% for Bio1. For Haemaphysalis qinghaiensis, the key environmental variables were 45% for Elev, 30.9% for Lucc and 18.4% for Bio12. Regarding the pathogens, the environmental factors influencing Borrelia burgdorferi contributed 61.5% for Lucc, 13.3% for Elev and 11.9% for Bio1. For Piroplasmida, the contribution was 62.1% for Lucc, 16.7% for Bio1 and 9.9% for Bio12. Rickettsia was influenced by factors accounting for 34.2% for Lucc, 29.7% for Elev and 17.3% for Bio12, while Anaplasma variables contributed 38.2% for Bio1, 26.6% for Lucc and 18.9% for Bio12. The finding indicated that the three predominantly ticks species (D. nuttalli, D. silvaru, and H. qinghaiensis) and the primary tick-borne pathogens (B. burgdorferi, Piroplasmida, Rickettsia, and Anaplasma) are predominantly concentrated in the source regions of the Yellow River, the Yangtze River, the Lancang River, and the eastern part of the Haixi Autonomous Prefecture. Projected under the ssp245 scenario, there is a notable expansion trend in the risk areas for ticks and tick-borne pathogens These findings are consistent with previous epidemiological studies on major ticks and tick-borne diseases in Qinghai conducted by our laboratory, this suggests the feasibility of using the MaxEnt model to predict the distribution of tick-borne disease transmission and compensates for the paucity of research on the Maxent model in the Qinghai Province.