bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection
Authors: Ichinohe Takeshi , Yamazaki Tatsuya , Koshiba Takumi , Yanagi Yusuke 
Published: October 2013

Significance
Mitochondria play pivotal roles not only in the energy production, apoptosis, and calcium storages, but also in innate antiviral immunity. Mitochondrial antiviral signaling expressed on the outer membrane of mitochondria is essential for intracellular viral RNA-mediated induction of type I interferon. In addition, damaged mitochondria generate reactive oxygen species required for nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome-dependent inflammatory responses. Here, we demonstrate that mitochondrial membrane potential-dependent association between NLRP3 and mitochondrial outer membrane protein mitofusin 2, a key regulator of mitochondrial fusion, is required for the full activation of the NLRP3 inflammasome after infection with RNA viruses. Our results highlight the importance of mitochondria as a platform of NLRP3 inflammasome activation.
A naturally occuring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms
Authors: Thomas-Chollier Morgane , Watson Lisa C. , Cooper Samantha B. , Pufall Miles A. , Liu Jennifer S. , Borzym Katja , Vingron Martin , Yamamoto Keith R. , Meijsing Sebastiaan H. 
Published: October 2013

Significance
For proteins to be able to have context-specific activities, they can adopt context-specific conformations that enhance or restrict their activity. For transcriptional regulatory factors, such a context-specific signal is provided by the sequence of the DNA response element to which it binds. Here we show how one signal, an alternative splicing event, rewires a transcriptional regulatory protein to respond differently to a second signal, the DNA sequence to which it binds, by changing the functional interplay between protein domains. Together, our findings argue that bidirectional allosteric signaling between the DNA:protein interface and other regulatory domains fine tunes the activity of transcriptional regulatory factors toward individual target genes.
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region
Authors: Reshetnyak Andrey V. , Nelson Bryce , Shi Xiarong , Boggon Titus J. , Pavlenco Alevtina , Mandel-Bausch Elizabeth M. , Tome Francisco , Suzuki Yoshihisa , Sidhu Sachdev S. , Lax Irit , Schlessinger Joseph 
Published: October 2013

Significance
The receptor tyrosine kinase KIT is aberrantly activated primarily by somatic mutations in gastrointestinal stromal tumors and in a subset of acute myeloid leukemia, melanoma, and other cancers. Treatment of these cancers with tyrosine kinase inhibitors shows durable clinical response, but drug resistance and disease progression eventually occur in all patients. Here we describe monoclonal antibodies that block the activity of KIT and its oncogenic mutant. Structural and biochemical analyses of anti-KIT antibodies in complex with a KIT fragment demonstrated that KIT antibodies bind to a critical Achilles heel region that is essential for receptor activation. These antibodies may provide a potentially unique therapeutic approach for the treatment of tumors driven by WT or oncogenically mutated KIT.
Drug interactions and dual diagnosis
Authors: Hamilton Ian , Pringle Rose 
Published: October 2013

Purpose
– Adverse drug reactions (ADR) and interactions for patients who use substances and have a mental health problem is an area that lacks attention in research, practice and policy. The purpose of this paper is to examine what is currently known about this topic.

Design/methodology/approach
– The paper explores the available literature and specialist information available on this subject.

Findings
– This is a complex area, which is compounded by limited empirical evidence. However, information is available which when combined with individual patient assessment there is the potential to reduce the risk of detrimental ADR and improve concordance to medication.

Originality/value
– The paper offers pragmatic suggestions which aim to improve the knowledge of practitioners and lessen the potential harm to patients.
Developing inter-disciplinary and inter-agency networks: reflections on a “community of practice” approach
Authors: E. Anderson Sarah , Hennessy Catherine , Cornes Michelle , Manthorpe Jill 
Published: October 2013

Purpose
– People with a dual diagnosis or other multiple and complex needs often require support from a range of services and agencies. Social policy has focused on achieving an integrated response from practitioners; however, service responses to this group frequently remain fragmented. Practitioners supporting these clients are likely to need knowledge drawn from multiple disciplines and awareness of complex and changing services. Research suggests the value of professional networks for knowledge transfer. The purpose of this paper is to describe one's approach to supporting integration and facilitating knowledge exchange through the development of “communities of practice”.

Design/methodology/approach
– The paper describes a “communities of practice” model, as implemented by researchers from King's College London and Revolving Doors Agency through their Communities of Practice Development Programme. It outlines potential benefits of the model – identified through focus groups and survey responses of members, facilitator interviews and the authors’ observations as community of practice members. Finally, it discusses challenges and limitations of this approach.

Findings
– Communities of practice are able to provide a forum for peer support and supervision to mediate feelings of role or service isolation and to sustain practitioner motivation. They can also facilitate inter-disciplinary and inter-agency knowledge transfer. However, the limited resources available to these local networks act as a barrier to developing their capacity to improve responses to people with multiple and complex needs.

Originality/value
– The paper uses a case study approach to outline the potential for a “communities of practice” approach to be used to improve responses to people with multiple and complex needs.
Online self and peer assessment of team work in accounting education
Authors: Anne Delaney Deborah , Fletcher Marty , Cameron Craig , Bodle Kerry 
Published: October 2013

Purpose
– The purpose of this study is to describe and evaluate the implementation of an online self and peer assessment model (SPARKPLUS) to assess team work skills of accounting students.

Design/methodology/approach
– This study describes the background and implementation of SPARKPLUS and employs a survey questionnaire administered to students enrolled in an undergraduate company accounting subject before and after the implementation of the model. The survey results and selected qualitative data are used to evaluate students' attitudes to group work and the impact of SPARKPLUS.

Findings
– The study suggests that students understand the benefits of group work activities in developing their technical knowledge in company accounting. However, students do not appreciate the value of group work activities in developing generic skills or how SPARKPLUS supports group work activities.

Practical implications
– Professional and accreditation bodies require evidence of teaching and learning activities and assessment of team work skills during the students' undergraduate accounting degree. This study demonstrates that students require significant teaching and learning activities in relation to team work skills and the assessment model for successful implementation.

Originality/value
– This study makes an original contribution to the accounting education literature pertaining to assessment of team work skills in two respects. First, the study outlines the design, implementation and preliminary evaluation of an online self and peer assessment model in an undergraduate company accounting course. Second, preliminary evidence concerning the impact of this model on group work activities and team work skills is provided.
Case studies in a passive learning environment: some Malaysian evidence
Authors: Nazli Nik Ahmad Nik , Sulaiman Maliah 
Published: October 2013

Purpose
– The purpose of this paper is to explore accounting students' perceived usefulness of case studies in Malaysia, which has a more passive learning environment, and if gender, prior academic performance and prior exposure to case studies influenced students' perceptions.

Design/methodology/approach
– A questionnaire survey on students' perceived usefulness of case studies based on Weil et al. was used with final-year students enrolled in an advanced management accounting course. The data were gathered over two semesters in 2006/2007.

Findings
– Findings reveal that generally students felt that the case method was very useful and gave them numerous benefits. However, there were no significant differences in the perceived usefulness of case studies across gender and prior academic performance. Some differences were observed between students with prior exposure to case studies and students without such exposure, in that students without prior exposure perceived higher benefits of case studies.

Research limitations/implications
– The study showed that students in a passive learning environment generally find case studies to be very beneficial.

Practical implications
– The case approach should be used more extensively and introduced earlier in accounting undergraduate programmes.

Originality/value
– This study is one of very few studies which have investigated students' perceived usefulness of case studies, in a developing country, Malaysia, where a more passive learning environment exists – addressing an important gap in the accounting education literature.
The readiness of universities in managing electronic records
Authors: Eze Asogwa Brendan 
Published: October 2013

Purpose
– The purpose of this study was to survey the level of readiness of three universities in Nigeria towards managing their digital records by assessing the e-records frameworks, infrastructures, and structural facilities that are available.

Design/methodology/approach
– The population of the study was 30 staff of the Registry Department in three Nigerian universities. Questionnaires, oral interviews, and check list were used during data collection. Data were analyzed using frequency tables, simple percentages, and bar charts.

Findings
– The paper found that universities in Nigeria are not ready to manage electronic records due to weak legislative and organizational frameworks. The paper recommends creation of awareness about e-records management, training of records personnel, adoption of hybrid records management and periodic auditing, provision of sustainable framework and infrastructure, among other things in Nigerian universities.

Research limitations/implications
– This study was carried out on only three out of more than 20 federal universities in Nigeria. Therefore, the sample size and geographical spread was inadequate for generalization of the findings.

Practical implications
– The paper demonstrates that, without proper planning and adoption of various international standards for records management, e-records created using modern technologies are likely to be inaccessible in Nigerian universities in future and consequently, the ability to remain accountable to the citizens will be compromised.

Originality/value
– The study exposed the simple tools and strategies for assessing a university's readiness before embarking on electronic records management in a digital age. The paper will serve as a catalyst to further discussion and research into e-records and archives management in Nigeria. It will lead to other records management initiatives in the library, archives and information management.
Health sciences information literacy in CMS environments: learning from our peers
Authors: Lyons Tierney , Warlick Stefanie 
Published: October 2013

Purpose
– With academic institutions' adoption of Course/Learning Management Systems (CMS), librarians are increasingly providing content through this delivery method. This study aims to identify practical information for librarians considering CMS content development or re-evaluation of online offerings.

Design/methodology/approach
– Academic libraries with health sciences information literacy programs within CMS were examined through a literature review and then queried through an online survey. Trends and issues identified within the literature were utilized to develop the survey. Collected data was analyzed to determine how librarians incorporate CMS into information literacy. Analysis focused on strategies used in development and delivery, benefits and challenges of CMS and pairing its content with traditional instruction methods.

Findings
– An overarching theme is the ease and accessibility of CMS, especially for distance learners and those with time restrictions. However, although online tools and learning spaces are readily available and beneficial, librarians maintain in-person instruction. A shift from primarily positive published reports by early adopters to more constructive feedback that stems from longer-term CMS experience is identified. Assessment practices of online library instruction need additional attention to provide a more robust approach.

Originality/value
– This unique examination of the last ten years of publications focusing on information literacy librarians' CMS activity is paired with a broad, updated examination of current trends. It identifies best practices related to time commitment, faculty relationships, and assessment for implementation in CMS environments and the importance of utilizing blended learning strategies.
Understanding the purchase intention towards remanufactured product in closed-loop supply chains
Authors: Wang Yacan , Wiegerinck Vincent , Krikke Harold , Zhang Hongdan 
Published: October 2013

Purpose– The paper aims to explore the reasons underlying the key assumption in the closed-loop supply chain (CLSC) literature that consumers' purchase intention is lower for remanufactured products than for new products. It aims to complement the predominantly operation-focused CLSC research by examining consumers' perception of and behavior relating to remanufactured products.Design/methodology/approach– A theoretical model is developed by integrating the concepts of perceived benefits and product knowledge with the theory of planned behavior and the theory of perceived risk. Then the model is examined through an empirical study in the Chinese automobile spare parts industry involving 288 respondents and using structural equation modeling.Findings– The results indicate that purchase intention is directly influenced by purchase attitude followed by perceived behavioral control and indirectly influenced by perceived risk, perceived benefit and product knowledge via attitude. Therefore, effective measures to promote consumers' purchase intention rely on coordinated policies built on multiple pillars instead of single factors.Originality/value– This is one of the first empirical studies to explore the factors that underpin consumers' purchase intention regarding remanufactured products. The results can be used to validate the key assumptions in operational models and foster new research in the context of CLSCs.
On the measurement and benchmarking of research impact among active logistics scholars
Authors: Rao Shashank , Iyengar Deepak , J. Goldsby Thomas 
Published: October 2013

Purpose– Scholarly interest in carrying out impactful research continues to remain high. Yet, given that citations of scholarly work can never decrease with time, traditional measures of research impact (such as raw counts of citations) unwittingly discriminate against early career researchers and also make it hard to identify future high impact scholars. In the current study, the paper compares several commonly used measures of research impact to identify one that best normalizes for the effect of career stage. The measure thus applies equally across most career stages, providing a usable impact benchmark for logistics scholars irrespective of seniority level. The paper also aims to present benchmarks on that metric to help logistics scholars identify their research impactvis-à-vistheir peers.Design/methodology/approach– Bibliometric data on the research of 702 logistics scholars were collected and analyzed by dividing the scholars into different cohorts based on seniority. Comparisons of different citation metrics were then made.Findings– The h-rate provides the most appropriate basis for comparing research impact across logistics scholars of various career stages. Benchmark h-rates are provided for scholars to identify their research impact.Originality/value– The authors are unaware of any other work in the logistics field that measures the research impact of logistics scholars in this manner.
Dynamic capabilities for fashion-luxury supply chain innovation
Authors: Caniato Federico , Moretto Antonella , Caridi Maria 
Published: October 2013

Purpose– This paper aims at developing a conceptual framework to identify the main features of supply chain innovation and to analyse the role of dynamic capabilities in implementing such innovations in the context of the fashion-luxury industry.Design/methodology/approach– The paper follows an exploratory approach based on one in-depth case study. The theoretical framework, developed through the literature review, is applied to a Italian fashion-luxury company, thus exploring its applicability in a real context and obtaining evidence in the area of supply chain innovation.Findings– The paper offers insights on supply chain innovation, by investigating an area under-explored in the existing literature. The paper provides a conceptual framework oriented to analyse the main features of supply chain innovation for fashion-luxury companies, by investigating the main determinants of innovation.Research limitations/implications– The proposed model provides initial insights into the topic of supply chain innovation in fashion-luxury companies. To date, the analysis is predominantly qualitative and therefore replication is needed to generalise the results.Practical implications– The paper identifies three different perspectives of supply chain innovation and the relationships between supply chain innovation and other types of innovations, which are hopefully useful for managers that are willing to introduce innovation inside fashion-luxury companies.Originality/value– The paper addresses a new topic, underexplored in the supply chain management literature, by considering a peculiar area of investigation, the fashion-luxury. Moreover, the paper investigates the topic of supply chain innovation through the support of empirical data.
Legitimate vs illegitimate: the luxury supply chain and its doppelganger
Authors: D'Amato Iolanda , Papadimitriou Thanos 
Published: October 2013

Purpose
– The increase in international trade, the advances in technology, the growing importance of the emerging markets are the main factors that have contributed to the explosion of counterfeiting experienced in recent years, estimated to be valued at about 5-7 per cent of the world trade. The luxury industry in Italy has been particularly hard hit and most brands nowadays are urgently looking for demand-side and supply-side strategies to track and control the phenomenon. The aim of this paper is to provide a supply chain view of counterfeiting and illegitimate trade phenomena, in a supply chain risk management perspective, to define and illuminate the interaction of the legitimate and the illegitimate supply chains.

Design/methodology/approach
– The paper introduces the LISC model to represent and include all the illegitimate trade phenomena under analysis such as pure counterfeiting, factory overruns, grey and parallel market, supply chain infiltrations, product diversion and sale of stolen goods

Findings
– The interrelations between legitimate and illegitimate supply chains are crucial to approach counterfeiting issue and define which illegitimate trade paths are more harmful to companies and customers.

Research limitations/implications
– The first limitation of the work is that the illegitimate trade categories defined in this paper mainly rely on data and phenomena collected from secondary sources that have not yet been directly observed by the authors. The second one is that a specific focus on high-end fashion industry was employed throughout this work: further analysis for evaluating the applicability and the significance of the illegitimate trade in other industries is still pending. The final limitation stems from the fact that it will be necessary to investigate the implications and the applicability of the model to the illegitimate on-line trade.

Practical implications
– During the course of the MI-FIDO project, the model and the selection rules identified for illegitimate trade family classification were used as a basis for defining the rules for anomalies detection to be included in a “track and trace” system developed the project team currently under with a major Italian fashion brand.

Originality/value
– To the authors
'
knowledge, this is the first work that attempts to present a concise and systematic approach to luxury illegitimate trade from a supply chain perspective. Understanding which legitimate-illegitimate supply chain interactions are the most damaging will help fashion luxury and other industries to battle the counterfeiting phenomenon more effectively
Comparing online and in-store shopping behavior towards luxury goods
Authors: Liu Xia , Burns Alvin C , Hou Yingjian 
Published: October 2013

Purpose
– The purpose of this paper is to compare and contrast the online and in-store shopping behavior towards luxury goods.

Design/methodology/approach
– Two studies are presented. Study one is qualitative in nature. It uses a mixed method approach and explores why luxury consumers decide to purchase luxury products online or in-store. The second study is a quantitative one. It tests the hypotheses drawn from the first study and validates the qualitative results.

Findings
– Online and in-store luxury shoppers are influenced by different motivational factors. Online luxury shoppers are price-conscious, prefer the online product availability and have a higher level of trust towards online customer reviews. In-store shoppers who are more averse to online risks find it very important to see the product personally before the purchase and value shopping experience and interactions. In addition, differences exist between the online shopping behaviors of regular and luxury shoppers.

Research limitations/implications
– It contributes to luxury consumption research and expands shopping motivation literature by investigating luxury buyer behavior in the online context.

Practical implications
– Luxury retailers should pay attention to the newly emerging segment of online luxury consumers. Lack of trust prevents more luxury consumers from shopping on the internet and the trustworthiness of the sellers can help attract potential shoppers. Luxury retailers can cater to the needs of different types of luxury buyers.

Originality/value
– This paper is the first exploratory, comparative study on luxury consumption in the online and physical store environments. It investigates the motivational factors that drive the shopping behavior of internet and in-store luxury shoppers.