bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuclear β-catenin accumulation is associated with increased expression of Nanog protein and predicts poor prognosis of non-small cell lung cancer
Authors: Li Xi-Qing , Yang Xing-Long , Zhang Gong , Wu Si-Pei , Deng Xu-Bing , Xiao Sheng-Jun , Liu Qiu-Zhen , Yao Kai-Tai , Xiao Guang-Hui 
Published: May 2013

Abstract

Background
Although the prognostic roles of β-catenin expression in non-small cell lung cancer (NSCLC) have been reported in several immunohistochemical (IHC) studies, the results were not consistent because some studies lack sufficient number of the positive cases or did not evaluate the subcellular localization features of the protein.

Method
In this study, we have evaluated the expression levels and subcellular localization of β-catenin and Nanog proteins IHC staining in tissue specimens from 309 patients with NSCLC, and explored their association with clinicopathological features and patient outcome.

Results
We showed that patients with negative expression of membranous beta-catenin had a trend towards shorter survival (p=0.064) than those with positive expression. In contrast to previous studies, we found that increased expression of either cytoplasmic or nuclear β-catenin was strongly associated with poor prognosis and was an independent prognosticator for overall survival (p <0.01). We further found that NSCLC cells frequently exhibited an abundance of nuclear Nanog protein which was significantly correlated with nuclear β-catenin expression (p <0.01) and poor prognosis (p <0.01). Interestingly, immunofluorescent staining results revealed that increased expression of Nanog and nuclear translocation of β-catenin occurred concomitantly in response to epidermal growth factor receptor(EGFR) signaling in A549 and H23 cells. Furthermore, western blot analysis show that nuclear β-catenin rather than cytoplasmic β-catenin expression in the A549 and H23 cells can be enhanced by adding EGF, Nanog expression in the A549 and H23 cells with knockdown of β-catenin can not be obviously enhanced by adding EGF.

Conclusion
We propose that evaluation of subcellular localization of β-catenin and Nanog expression is of clinical significance for patients with NSCLC.
Patterns of failure in patients with locally advanced rectal cancer receiving pre-operative or post-operative chemoradiotherapy
Authors: Yeo Seung-Gu , Kim Min-Jeong , Kim Dae Yong , Chang Hee Jin , Kim Min Ju , Baek Ji Yeon , Kim Sun Young , Kim Tae Hyun , Park Ji Won , Oh Jae Hwan 
Published: May 2013

Abstract

Background
We investigated patterns of failure in patients with locally advanced rectal cancer (LARC) according to chemoradiotherapy (CRT) timing: pre-operative versus post-operative. Also, patterns of failure, particularly distant metastasis (DM), were analyzed according to tumor location within the rectum.

Methods
In total, 872 patients with LARC who had undergone concurrent CRT and radical surgery between 2001 and 2007 were analyzed retrospectively. Concurrent CRT was administered pre-operatively (cT3–4) or post-operatively (pT3–4 or pN+) in 550 (63.1%) and 322 (36.9%) patients, respectively. Median follow-up period was 86 (range, 12–133) months for 673 living patients. Local recurrence (LR) was defined as any disease recurrence within the pelvis, and any failure outside the pelvis was classified as a DM. Only the first site of recurrence was scored.

Results
In total, 226 (25.9%) patients developed disease recurrence. In the pre-operative CRT group, the incidences of isolated LR, combined LR and DM, and isolated DM were 17, 21, and 89 patients, respectively. In the post-operative CRT group, these incidences were 8, 15, and 76 patients, respectively. LR within 2 years constituted 44.7% and 60.9% of all LRs in the pre-operative and post-operative CRT groups, respectively. Late (> 5 years) LR comprised 13.2% and 4.3% of all LRs in the pre-operative and post-operative CRT groups, respectively. The lung was the most common DM site (108/249, 43.4%). Lung or para-aortic lymph node metastasis developed more commonly from low-to-mid rectal tumors while liver metastasis developed more commonly from upper rectal tumors. Lung metastasis occurred later than liver metastasis (n = 54; 22.6 ± 15.6 vs. 17.4 ± 12.1 months; P = 0.035).

Conclusions
This study showed that LARC patients receiving pre-operative CRT tended to develop late LR more often than those receiving post-operative CRT. Further extended follow-up than is conventional may be necessary in LARC patients who are managed with optimized multimodal treatments, and the follow-up strategy may need to be individualized according to tumor location within the rectum.
Life Experiences of Instability and Sexual Risk Behaviors Among High‐Risk Adolescent Females
Authors: Secor‐Turner Molly , McMorris Barbara , Sieving Renee , Bearinger Linda H. 
Published: May 2013

ContextUnderstanding the interplay of multiple contexts of adolescents’ sexual risk behaviors is essential to helping them avoid pregnancy and STDs. Although a body of research has identified multiple individual‐ and family‐level variables associated with adolescents’ sexual risk behaviors, relatively few studies have examined relationships between these behaviors and latent indicators of unstable, chaotic environments.MethodsIn 2007–2008, a sample of 241 sexually active adolescent females who were at high risk for pregnancy and STDs were recruited through two school‐based clinics and two community clinics in Minneapolis and St. Paul. Confirmatory factor analysis was used with baseline data to specify latent constructs of individual risk and family disengagement. Structural equation models examined longitudinal relationships between baseline measures of these constructs and sexual risk behaviors assessed six months later.ResultsThe latent construct of individual risk encompassed substance use, violence perpetration, violence victimization and having witnessed violence; that of family disengagement included family disconnection, poor family communication and perceived lack of safety at home. Baseline level of individual risk was positively associated with number of male sex partners six months later (path coefficient, 0.2); it was not associated with consistent condom use at follow‐up. Level of family disengagement was negatively associated with condom use consistency six months later (−0.3), but was not associated with number of male sex partners.ConclusionsTo meet the health needs of vulnerable adolescents, health systems should incorporate coordinated and interdisciplinary services that acknowledge adolescents’ relevant familial and social contexts.
From exceptional collections to motivic decompositions via noncommutative motives
Authors: Marcolli Matilde , Tabuada Gonçalo 
Published: May 2013

Abstract

Making use of noncommutative motives we relate exceptional collections (and more generally semi-orthogonal decompositions) to motivic decompositions. On one hand we prove that the Chow motive M(𝒳)ℚ of every smooth and proper Deligne–Mumford stack 𝒳, whose bounded derived category 𝒟
b
(𝒳) of coherent schemes admits a full exceptional collection, decomposes into a direct sum of tensor powers of the Lefschetz motive. Examples include projective spaces, quadrics, toric varieties, homogeneous spaces, Fano threefolds, and moduli spaces. On the other hand we prove that if M(𝒳)ℚ decomposes into a direct sum of tensor powers of the Lefschetz motive and moreover 𝒟
b
(𝒳) admits a semi-orthogonal decomposition, then the noncommutative motive of each one of the pieces of the semi-orthogonal decomposition is a direct sum of ⊗-units. As an application we obtain a simplification of Dubrovin's conjecture.
Combination of neutron imaging (NI) and digital image correlation (DIC) to determine intra-ring moisture variation in Norway spruce
Authors: Lanvermann Christian , Sanabria Sergio J. , Mannes David , Niemz Peter 
Published: May 2013

Abstract
The hygroscopic behavior of wood has a strong influence on its mechanical performance, yet the moisture gradients within the growth ring structure have not been sufficiently investigated. The main challenge is that moisture variations are coupled with strong sample deformation, which complicates the spatial referencing of moist and dry states. In this work, neutron imaging (NI) for the detection of water and digital image correlation (DIC) for the detection of local deformation were combined to calculate the local gravimetric moisture content (MCgrav) and the volumetric moisture content (MCvol) within single growth rings. Specimens of Norway spruce [Picea abies (L.) Karst.] were exposed to an adsorption-desorption cycle, with relative humidity (RH) steps varying from 0% (oven dry) up to 95% RH. After each acclimatization step, neutron transmission and DIC images were acquired. The local deformations determined by DIC were used to assign the corresponding dry density in the undeformed state to the compartment in a moist state and thus to calculate its MC by NI. No significant MC gradients could be found between earlywood (EW) and latewood (LW) within ±0.5% accuracy. However, strong density gradients between EW and LW can be directly correlated with MCvol. It appears that the MC in the cell wall is constant regardless of the particular growth ring position.
Is yoga an effective treatment in the management of patients with chronic low back pain compared with other care modalities – a systematic review
Authors: Hill Christopher 
Published: May 2013

Abstract

Objective: The aim of the study was to assess randomized-control trials (RCTs) to ascertain whether yoga is an effective treatment in the management of patients with chronic low back pain (cLBP) compared with other care modalities.

Methods: A search strategy was formulated with key concepts identified using the PICO process. Four databases were searched in June 2012. Appropriate eligibility criteria were set and implemented.

Results: Four randomized control trials met the inclusion criteria. All four papers found that yoga lead to a significant improvement in back function, and three demonstrated a significant improvement in back pain when compared with certain care modalities. All papers had significant limitations identified, however.

Conclusions: Given the limitations identified within the studies, the conclusions drawn must be considered conservatively. Although early results appear promising, but further well-designed RCTs are warranted, with multiple, specified comparator care modalities before firm conclusions can be gained.
Task Allocation Optimization in Collaborative Customized Product Development Based on Adaptive Genetic Algorithm
Authors: Bao Beifang , Yang Yu , Liu Aijun , Zhao Jiali , Li Leiting 
Published: May 2013

Abstract
Due to the currently insufficient consideration of task fitness and task coordination for task allocation in collaborative customized product development, this research was conducted based on the analysis of collaborative customized product development process and task allocation strategy. The definitions and calculation formulas of task fitness and task coordination efficiency were derived, and a multiobjective optimization model of product customization task allocation was constructed. A solution based on adaptive genetic algorithm was proposed, and the feasibility and effectiveness of the task allocation algorithm were tested and verified using a 5-MW wind turbine product development project as example.
Cloud Manufacturing Concept as a Tool of Multimodal Manufacturing Systems Integration
Authors: Kłosowski Grzegorz 
Published: May 2013

Abstract
The following article deals with a novel approach to manufacturing in the context of the increasing demand for system and process integration. This integration chiefly applies to concrete facets of manufacturing tasks which must be taken into consideration in the stage of planning and preparation for complex production processes. Those facets are primarily exemplified by order types (such as production, service and cooperative commissions etc.), production models (e.g. discrete and process modeling), product categorization based on established criteria (e.g. production technology, complexity level, used materials and extras, weight, etc.) as well as many other aspects that hold great significance in the automatization of manufacturing processes. When more advanced orders are to be realized, one of the main challenges posed by this situation is the need to accomplish multiple operations which due to their different nature, scope and scale (e.g. varied processing types: heat and plastic treating, machining etc.) have to be conducted by different contractors. In order to address those key problems and reduce the negative impact of multimodality, the author proposes a manufacturing cloud (also known as cloud manufacturing) which is a variant of a groundbreaking, yet well-established concept - cloud computing. This paper presents the chief notions of this method created specifically with integrated multimodal systems and production processes. The author also highlights key problems that should be addressed before this solution can be used in practice.
The Risk Assessment in the Logistic Processes Structures
Authors: Kulińska Ewa 
Published: May 2013

Abstract
This paper presents the nature of logistic processes functioning in manufacturing companies with special risk factors situations. The author's parameterization model of the value added was generated as a result of the logistic processes. Author refers to differences between all-in and real costs caused by appearance of risk factors in logistic processes. Author also identifies the change of the value added measured with the net profit and its results.
The hidden population: Some methodological issues about estimation of problematic drug use
Authors: Dahlberg Mikael , Anderberg Mats 
Published: May 2013

Aim This article analyses and discusses the estimation of serious or problematic drug use through an empirical example based on a local Swedish study in Gothenburg. Methods and Data This was a case-finding study with questionnaires directed at organisations which have contact with the target group. The material was supplemented with information from the two documentation systems DOK and ASI. A total of 2,148 reports were collected. Health care data of 1,096 individuals was also collected for analysis with the truncated Poisson method. Analyses with capture-recapture or truncated Poisson were conducted to calculate the size of the hidden population. Results The statistical analyses resulted in variable numbers for the hidden population, and the total prevalence of serious drug abuse in Gothenburg is estimated to be between 2,200 and 4,400 people. Conclusion The study shows that estimation of the presence and prevalence of problematic drug abuse involves many methodological difficulties and challenges. The significant variation of the size of the hidden population presented in the study raises doubts about the reliability and validity of the different methods. The methods are clearly sensitive to the importance of fulfilling the different basic assumptions.
Working with Different Logics: A Case Study on the use of the Addiction Severity Index in Addiction Treatment Practice
Authors: Björk Alexander 
Published: May 2013

Aim This article explores the implementation and use of the Addiction Severity Index in addiction treatment practice, both as a clinical instrument and as a way of facilitating outcome measurement. This is regarded as incorporating “laboratory logic” into clinical practice characterised by “the logic of care”. Data The data is based on ethnographic fieldwork in a Swedish metropolitan social service agency known for its systematic ASI work. Results The findings suggest that much effort must be dedicated to co-ordinate activities in the agency in line with the laboratory logic, making sure that the interviews are administered systematically. In use, the ASI and the variables in clinical practice are adjusted to each other, making it possible to follow both logics at the same time. In some cases, however, there is a conflict: the ASI becomes an extra task that does not further the clinical work. Once collected, the ASI data must be co-ordinated in line with other information. This has not yet been realised in the agency, which makes the value of the ASI data unknown. Conclusions It requires hard work to handle the two logics simultaneously in addiction treatment practice: activities must be co-ordinated, and instruments and variables in clinical practice must be continuously “tinkered” with. Further, outcome measurement is not only about systematic use of standardised instruments, but much work must be done after the ASI data has been collected.
Alkoholmissbruk och självbestämmande – en kartläggning av den svenska hemtjänstens förutsättningar att arbeta med äldre personer med alkoholproblem
Authors: Gunnarsson Evy 
Published: May 2013

Aim Alcohol abuse and self-determination-a mapping of the conditions for home care work with older persons with alcohol problems in Sweden. The aim of this study was to investigate the conditions within home care services when working with older persons with alcohol abuse. Design A telephone survey has been carried out and middle managers for needs assessment officers and middle managers for home care staff have been interviewed. The managers in 25 municipalities in the Stockholm area took part in the study. Results It was common that care workers were in regular contact with older people with alcohol abuse. However, very few had any training regarding how to treat older people with alcohol abuse and there was no specialization within this field. A conflicting task was the question of buying alcohol to alcohol addicts. The self determination of older people was the guideline. The home care workers had little or no cooperation with misuse teams in the municipalities. The municipalities had no guidelines for the work with older people with alcohol abuse and the responsibility was pressed down to the lowest level in the organization. Conclusions To a great extent, home care workers stand alone in the work with older people with alcohol problems.
Mohammed VI, despote malgré lui
Authors: Benchemsi Ahmed 
Published: May 2013

À en croire les médias internationaux, impressionnés par la manière subtile dont la monarchie marocaine a tiré son épingle du Printemps arabe, Mohammed VI serait un jeune roi avisé et ouvert à la démocratie. Mais à y voir de plus près, le roi du Maroc dispose de la panoplie du satrape oriental : pouvoirs absolus légitimés par le droit divin, richesse personnelle illimitée, culte de la personnalité extravagant... tout y est. Sauf, peut-être la personnalité autocratique qui va avec.
Au-delà de « l'opposition à sa Majesté » : mobilisations, contestations et conflits politiques au Maroc
Authors: Catusse Myriam 
Published: May 2013

Le Mouvement du 20 février questionne les dynamiques qui traversent les oppositions marocaines et plus généralement l’état des forces politiques. Au sein d’un régime de pluralisme limité, dominé par l’institution monarchique où le « dissensus » politique fut souvent neutralisé par la force autant que par la persuasion (ou la cooptation), d’aucuns seraient tentés de réactualiser un schéma maintes fois convoqué pour rendre compte des relations entre le souverain et les élites politiques : celui d’un désamorçage savant mais imparable de toute forme de dissidence. Pourtant, l’histoire sociale et politique des oppositions marocaines peut se lire bien différemment. En considérant des formes plurielles de contestations, de mobilisations et de conflits politiques, cet article montre au contraire que les arènes de l’opposition sont à géométrie variable, qu’elles sont négociées et non d’avance fixées par en haut ; qu’elles sont le lieu de pratiques, d’engagements qui se réinventent et s’adaptent selon les enjeux, la conjoncture et la répression.
Changement de cap et transition politique au Maroc et en Tunisie
Authors: Mohsen-Finan Khadija 
Published: May 2013

L’analyse comparative des transitions marocaine et tunisienne montre qu’au Maroc, même si le roi reste la pièce maîtresse du dispositif politique, le changement n’en demeure pas moins réel. Profitant des espaces de liberté concédés à la faveur d’une ouverture – aussi stratégique fût-elle – et de l’effet de contagion des autres soulèvements, le mode de revendication des Marocains et leurs attentes sont aujourd’hui radicalement différents. En Tunisie, malgré la révolution, la rupture avec le passé est loin d’être franche. La transition s’opère en se référant à « l’esprit et aux valeurs de la révolution », tout en conservant de nombreuses institutions et pratiques du passé. Malgré cela, la dynamique du changement réel et profond est engagée de manière irréversible.
Deep-Hole Subsea Excavation Utilizing the Most Current Technology
Authors: Webb Chuck 
Published: May 2013

Abstract
TETRA Offshore Services has developed a novel approach to the use of heavy subsea excavation tools in conjunction with USBL positioning and three dimensional sonar systems to successfully and safely excavate two subsea holes, 75 foot and 60 foot below mud line, to support the plug and abandonment of several wells and removal of two downed platforms in the Gulf of Mexico (GOM). This work took place at two locations within the GOM and over a period of three years. This manuscript will discuss, in detail, the lessons learned during these excavations including the modeling of how GOM clays hydrate and the proper application of excavation tools to varying soil hardness, the development of three dimensional sonar to assist in diver safety and in positioning of the excavation tools in a real-time environment, and a comparison of the various types of excavation tools and how to maximize their utility. The discussion will include the best methods found for employing each type of technology and the techniques developed to use multiple tools in concert to move soils in the most effective manner possible. To conclude, concepts for integrating and utilizing the next tier of emerging technologies and efforts to integrate those technologies will be suggested within the current process to maximize execution efficiency and assist in future excavation as the abandonment market moves into deeper water.

Introduction
For the sake of this discussion, a deep subsea hole will be defined as any seafloor excavation that is deeper than 15 feet below mud line (BML) which will require diver access to conduct some form of work will extend beyond the hydration period of the soils being excavated. In the Gulf of Mexico oil and gas sector, this type of hole is generally excavated where limited access exists to a subsea wellbore for well plug and abandonment (P&A) usually due to bending of the conductor or internal casings. This casing bending usually occurs after a catastrophic collapse of a platform during a severe storm. Most subsea P&A operations require wellhead access to be within twenty degrees of vertical and have at least 1.5 inches of access within the tubing. If either of these criteria is not met within the conductor interface with the seafloor, then the well conductor must be excavated until " straight?? pipe conditions are met. This presentation will focus on two deep holes dug in Eugene Island and Ship Shoal to respective depths of 75 and 60 feet BML. Each of these excavations were executed in varying water depths and led to specific lessons, which then led to more specialized processes being developed.