bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathogenicity of Bovine Neonatal Pancytopenia-associated vaccine-induced alloantibodies correlates with Major Histocompatibility Complex class I expression
Authors: Benedictus Lindert , Luteijn Rutger D. , Otten Henny , Jan Lebbink Robert , van Kooten Peter J. S. , Wiertz Emmanuel J. H. J. , Rutten Victor P. M. G. , Koets Ad P. 
Published: August 2015

AbstractBovine Neonatal Pancytopenia (BNP), a fatal bleeding syndrome of neonatal calves, is caused by maternal alloantibodies absorbed from colostrum and is characterized by lymphocytopenia, thrombocytopenia and bone marrow hypoplasia. An inactivated viral vaccine is the likely source of alloantigens inducing BNP-associated alloantibodies in the dam. In this study the specificity of BNP alloantibodies was assessed and was linked to the pathology of BNP. We demonstrated that Major Histocompatibility Complex class I (MHC I) and Very Late Antigen-3, an integrin α3/β1 heterodimer, were the major targets of BNP alloantibodies. However, alloantibody binding to various bovine cell types correlated with MHC I expression, rather than integrin β1 or α3 expression. Likewise, alloantibody-dependent complement-mediated cell lysis correlated strongly with MHC I expression. Examination of several tissues of third trimester bovine foetuses revealed that cells, shown to be affected in calves with BNP, were characterized by high MHC class I expression and high levels of alloantibody binding. We conclude that in spite of the heterogeneous specificity of BNP associated maternal alloantibodies, MHC I-specific antibodies mediate the pathogenicity of BNP in the calf and that cells with high MHC I expression were preferentially affected in BNP.
The heat shock response restricts virus infection in Drosophila
Authors: Merkling Sarah H. , Overheul Gijs J. , van Mierlo Joël T. , Arends Daan , Gilissen Christian , van Rij Ronald P. 
Published: August 2015

AbstractInnate immunity is the first line of defence against pathogens and is essential for survival of the infected host. The fruit fly Drosophila melanogaster is an emerging model to study viral pathogenesis, yet antiviral defence responses remain poorly understood. Here, we describe the heat shock response, a cellular mechanism that prevents proteotoxicity, as a component of the antiviral immune response in Drosophila. Transcriptome analyses of Drosophila S2 cells and adult flies revealed strong induction of the heat shock response upon RNA virus infection. Dynamic induction patterns of heat shock pathway components were characterized in vitro and in vivo following infection with different classes of viruses. The heat shock transcription factor (Hsf), as well as active viral replication, were necessary for the induction of the response. Hsf-deficient adult flies were hypersensitive to virus infection, indicating a role of the heat shock response in antiviral defence. In accordance, transgenic activation of the heat shock response prolonged survival time after infection and enabled long-term control of virus replication to undetectable levels. Together, our results establish the heat shock response as an important constituent of innate antiviral immunity in Drosophila.
Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension
Authors: He XiaoCong , Lin Min , Sha BaoYong , Feng ShangSheng , Shi XingHua , Qu ZhiGuo , Xu Feng 
Published: August 2015

AbstractUnderstanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane tension on translocation, it is generally thought that tension should disorder the membrane structure and weaken its strength, thereby facilitating penetration. However, our coarse-grained molecular dynamics simulation results showed that membrane tension can restrain polyarginine translocation across the asymmetric membrane and that this effect increases with increasing membrane tension. We also analyzed the structural properties and lipid topology of the tensed membrane to explain the phenomena. Simulation results provide important molecular information on the potential translocation mechanism of peptides across the asymmetric membrane under tension as well as new insights in drug and gene delivery.
ACS‐fed UWB‐MIMO antenna with shared radiator
Authors: Zhang Jing‐Yi , Zhang Fan , Tian Wen‐Peng , Luo Yong‐Lun 
Published: August 2015

A novel asymmetric coplanar strip (ACS)‐fed multiple‐input–multiple‐output (MIMO) antenna working in the ultra‐wideband (UWB) frequency band with a shared radiator is discussed. The proposed antenna is composed of a radiator which is shared by two antenna elements in order to achieve a very compact size of 26 × 26 mm2. By etching an I‐shaped slot in the radiator and attaching a rectangular patch on the back, the operating bandwidth is broadened and a high isolation between the two antenna elements is realised. The stub from the ground also has a great effect on the return loss and isolation. The measured results show that the working frequency band of the MIMO antenna covers 3.1–10.6 GHz with an isolation of more than 15 dB. Furthermore, the simple feeding structure and compact size could enable the proposed antenna to be used in portable devices.
Multi‐round dynamic swap optimisation for table‐based steganography
Authors: Mao Qian , Bharanitharan Karunanithi , Chang Chin‐Chen 
Published: August 2015

The reference‐table‐based (RTB) steganography employs two pixels to conceal a secret digit, according to a predetermined reference table. Most of the RTB steganographic schemes discussed in the literature do not consider the non‐uniformity of the secret digits and the locating numbers indicated by the pixel pairs. In contrast, the non‐uniformity of the locating numbers exists for most of host images. When a non‐uniform secret sequence is embedded, the quality control of the stego image is quite challengeable when compared with a uniform secret sequence. To the best of the authors knowledge, most of the existing algorithms focus on the uniform sequences. In this study, they propose a multi‐round dynamic swap optimisation (MRDSO) algorithm for RTB steganography, which is more suitable for non‐uniform secret sequences. By optimising the permutation of the reference table, the proposed algorithm increases the scenarios that the locating number indicated by the pixel pair is equal to the secret digit, which means that these host pixels can carry the secret digit without any distortion. The experimental results show that the proposed MRDSO algorithm increases the quality of the stego image by 0.1–1.7 dB.
Long‐distance non‐line‐of‐sight ultraviolet communication channel analysis: experimentation and modelling
Authors: Liao Linchao , Drost Robert J. , Li Zening , Lang Tian , Sadler Brian M. , Chen Gang 
Published: August 2015

In this study, the long‐distance non‐line‐of‐sight (NLOS) ultraviolet (UV) communication channel is characterised using experimental data and theoretical modelling. Experimental measurements of path loss and pulse broadening effects at distances of up to 4 km are reported and analysed, and comparisons between the field test data and a Monte Carlo multiple‐scattering channel model provides strong evidence for the validity of the theoretical modelling approach. In addition, measurements probing the effects of turbulence are also considered, but in this case, the authors find limited experimental support for existing turbulence models, an important result suggesting the need for refined turbulence modelling. Finally, implications for NLOS UV communication performance at long ranges are examined. Overall, the experimental and numerical results serve to advance the study of NLOS UV channel modelling, an essential component of communication system design.
Soft‐switching forward DC–DC converter using a continuous current mode for electric vehicle applications
Authors: Ibanez Federico Martin , Echeverria Jose Martin , Astigarraga Daniel , Fontan Luis 
Published: August 2015

This study presents the analysis and design of a novel technique that improves the efficiency of the conventional forward DC–DC converter by reducing switching losses, along with a comprehensive analysis of the circuit and detailed information for designers. The converter uses the current control mode to trigger the switches. To use this control mode, an equalising circuit is presented in the input port to guarantee that the voltage in each half‐switching period will be equal; otherwise, the current control mode cannot be applied. A 5 kW step‐down (from 350–500 to 28.8 V) prototype is presented and compared with the traditional hard‐switching forward converter for fully electric vehicle applications. In addition, the small‐signal characteristics and the dynamic response for load variation are presented. Efficiency improvements of over 2% are obtained.
Robust lateral double‐diffused MOS with interleaved bulk and source for high‐voltage electrostatic discharge protection
Authors: Wang Yang , Jin Xiangliang , Yang Liu 
Published: August 2015

A device with bulk and source interleaved dotting is fabricated in a 0.5‐µm 24 V CDMOS process, and the root cause of why it improves the multi‐finger high‐voltage lateral double‐diffused MOS (LDMOS)’s electrostatic discharge (ESD) robustness is detected by Atlas three‐dimensional device simulation and transmission line pulse system. Such device structure obtains strong ESD robustness by enlarging the intrinsic base resistance without increasing device area and sacrificing any ESD performance of nLDMOS. The measurement results demonstrated that, compared with traditional gate‐grounded nLDMOS (GG‐nLDMOS) with a total length of 400 μm, the proposed device can effectively raise the secondary breakdown current (It2) from 2.43 A up to 5.55 A, and enhance the ESD current discharge efficiency from 0.29 to 0.70 mA/μm2.
Parallel operation of inverter using trans‐Z‐source network
Authors: Aleem Zeeshan , Shin Dongsul , Cha Honnyong , Lee Jong‐Pil , Yoo Dong‐Wook , Peng Fang Z. 
Published: August 2015

There is strong demand for high‐power application for photovoltaic and wind power generation systems. The realisation of a high power conversion system is usually limited by the available switching devices because of the maximum voltage and current ratings, losses and switching frequency. Thus, utilising parallel‐connected power converters rated at more minute power levels are highly desirable. A robust approach for such a realisation would result in many advantages, such as modularity, ease of maintenance, (n + 1) redundancy and high reliability. The parallel operation of a voltage‐fed (VF) trans‐Z‐source inverter (ZSI) is presented. A two parallel connected VF‐trans‐ZSI is introduced and a similar concept is extended to N‐parallel connected inverter. A 2.9 kW prototype inverter is built and tested to verify the performance of the proposed inverter.
Convergent synthesis of 4,5-branched inner-core oligosaccharides of lipopoly- and lipooligosaccharides
Authors: Yi Ruiqin , Narimoto Hirofumi , Nozoe Miku , Ichiyanagi Tsuyoshi 
Published: August 2015

Abstract
The convergent synthesis of branched inner-core oligosaccharides of lipopoly- and lipooligosaccharide with a 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) disaccharide acceptor was achieved. The l-glycero-d-manno-heptopyranose (Hep) units for the branched core oligosaccharide Galβ(1-4)Glcβ(1-4)Hep and Hepα(1-3)Hep were prepared from the corresponding Hep building blocks. To obtain 4,5-branched core oligosaccharide structures, the common acceptor Kdoα(2-4)Kdo was glycosylated with the Hep units.
Negative expectancies measured with the Substance Use Beliefs Questionnaire can differentiate controls from those in treatment for alcohol dependence
Authors: Kouimtsidis Christos , Stahl Daniel , West Robert , Drummond Colin 
Published: August 2015

Purpose
– The purpose of this paper is to test the discriminative validity of the Substance Use Beliefs Questionnaire (SUBQ) with alcohol dependent users, by assessing if the new tool can successfully differentiate between two extreme groups.

Design/methodology/approach
– The criterion used to select the two extreme groups was participation or not in treatment for alcohol dependence. Score of the Severity of Alcohol Dependence Questionnaire (SADQ) was used as a secondary confirmation criterion of extreme difference.

Findings
– In all, 98 staff and 94 people in treatment for alcohol dependence were recruited. The treatment group scored 30.83 higher than the control on SADQ, 10.76 on positive and 28.98 on negative expectancies. Negative expectancies score had correctly classified 88.5 per cent and positive expectancies score only 66 per cent of the original grouped cases. The area under the Receiver Operating Characteristics (ROC) curve for negative expectancies was 0.94 (very good) with a cut-off point of 43.5 with 89 per cent sensitivity and 92 per cent specificity. The area under the ROC curve for positive expectancies was 0.73 (fair). Due to the shape it was difficult to identify a cut-off point.

Research limitations/implications
– The results support the discriminative validity of the negative expectancies sub scale of the SUBQ between two extreme groups. With only the use of negative expectancies score participants could be classified correctly to those of the control and those of the treatment group.

Originality/value
– SUBQ is the first tool to measure outcome expectancies across substances, facilitating relevant research with poly substance users. Future research needs to explore the discriminative validity of the tool with the other three substance groups (smokers, stimulant and opioids users), involved in the development and validation of the SUBQ.
“Take home” naloxone: what does the evidence base tell us?
Authors: Breedvelt Josefien J. F. , Tracy Derek K. , Dickenson Emily C. , Dean Lucy V. 
Published: August 2015

Purpose
– Opiod users are at high risk of suffering from drug overdoses. Naloxone has been used for decades in emergency treatment settings to reverse the symptoms of opioid overdose. Pilot studies and regional programmes have been rolled out to make naloxone more widely available. This review of user/carer administration of naloxone – so-called “take home naloxone” – aims to provide health professionals and interested readers with an up-to-date evidence base, clinical implications and practical concern considerations for such community management. The paper aims to discuss these issues.

Design/methodology/approach
– A review and analysis of the recent literature on naloxone.

Findings
– The evidence base suggests training and education is effective in preparing users for wider naloxone distribution. Furthermore, studies of varying quality indicate that naloxone may prove useful in reducing overdose-related deaths. However, even after implementation ineffective response techniques continued to be used at times and there remained a heistance to call medical services post overdose. Intranasal naloxone may reduce some of the risks associated with intramuscular naloxone. Ethical considerations, including provision of a needle and syringe kit to the community, should be considered. Studies suffered from a lack of follow-up data and methodological difficulties are associated with establishing opioid-related deaths post implementation. Two running trials in the UK might mitigate these concerns.

Research limitations/implications
– Future research is needed to address wider context of an overdose and targeting associated risk factors.

Originality/value
– Clinicians and other professionals will be informed on the most up-to-date evidence base and which areas are improtant to consider when take-home naloxone is introduced in their services.
Dissidents with an innovation cause? Non-institutionalized actors’ online social knowledge sharing, solution-finding tensions and technology management innovation
Authors: de Kervenoael Ronan , Bisson Christophe , Palmer Mark 
Published: August 2015

Purpose– Traditionally, most studies focus on institutionalized management-driven actors to understand technology management innovation. The purpose of this paper is to argue that there is a need for research to study the nature and role of dissident non-institutionalized actors’ (i.e. outsourced web designers and rapid application software developers). The authors propose that through online social knowledge sharing, non-institutionalized actors’ solution-finding tensions enable technology management innovation.Design/methodology/approach– A synthesis of the literature and an analysis of the data (21 interviews) provided insights in three areas of solution-finding tensions enabling management innovation. The authors frame the analysis on the peripherally deviant work and the nature of the ways that dissident non-institutionalized actors deviate from their clients (understood as the firm) original contracted objectives.Findings– The findings provide insights into the productive role of solution-finding tensions in enabling opportunities for management service innovation. Furthermore, deviant practices that leverage non-institutionalized actors’ online social knowledge to fulfill customers’ requirements are not interpreted negatively, but as a positive willingness to proactively explore alternative paths.Research limitations/implications– The findings demonstrate the importance of dissident non-institutionalized actors in technology management innovation. However, this work is based on a single country (USA) and additional research is needed to validate and generalize the findings in other cultural and institutional settings.Originality/value– This paper provides new insights into the perceptions of dissident non-institutionalized actors in the practice of IT managerial decision making. The work departs from, but also extends, the previous literature, demonstrating that peripherally deviant work in solution-finding practice creates tensions, enabling management innovation between IT providers and users.
Information disclosure of social media users
Authors: Benson Vladlena , Saridakis George , Tennakoon Hemamaali 
Published: August 2015

Purpose
– The purpose of this paper is to bridge the gap in the existing literature by exploring the antecedents of information disclosure of social media users. In particular, the paper investigates the link between information disclosure, control over personal information, user awareness and security notices in the social context, all of which are shown to be different from existing studies in e-commerce environments.

Design/methodology/approach
– The authors collected and analysed data from 514 social network users. The model is estimated using ordinary least squares and robust standard errors are estimated using the Huber-White sandwich estimators.

Findings
– The results show that in social networking contexts, control over personal information is negatively and statistically associated with information disclosure. However, both user awareness and security notices have a positive statistical effect on information disclosure.

Originality/value
– Whilst research on issues of individual information privacy in e-commerce is plentiful, the area of social networking and privacy protection remains under-explored. This paper provides a useful model for analysing information disclosure behaviour on social networks. The authors discuss the practical implications of the findings for actors in social media interactions.
Are all signals equal? Investigating the differential effects of online signals on the sales performance of e-marketplace sellers
Authors: Li Huifang , Fang Yulin , Wang Youwei , Lim Kai H. , Liang Liang 
Published: August 2015

Purpose– In the competitive e-marketplace today, sellers are using an increasing number of signals to entice customers to make online purchases. However, how differential these signals are in terms of their capacity to improve sales performance has not yet been investigated. The paper aims to discuss this issue.Design/methodology/approach– Drawing on signaling theory and grounded in the context of China’s largest e-marketplace, Taobao, this study investigated the different effects of five commonly used signals on the sales performance of e-marketplace sellers.Findings– The authors find that warranty has the highest effect on sales performance, followed by overall rating, mean detailed seller rating, percent of positives, and web site quality.Originality/value– First, this study builds on signaling theory and contributes to the e-marketplace literature by providing new insights into how specific signals differentially affect sales performance in the e-marketplace (with evidence from a large-scale empirical analysis). Second, the study extends the applicability of signaling theory to the e-marketplace domain by incorporating distinctive features of the e-marketplace into the original signaling theory. Finally, the findings lend practical support to e-marketplace sellers’ investment decisions on signals and provide guidelines for deployment of such signals.
Competitive priorities and knowledge management
Authors: Hussain Matloub , Ajmal Mian M. , Khan Mehmood , Saber Hussein 
Published: August 2015

Purpose– The purpose of this paper is to identify attributes of knowledge management (KM) for large and small manufacturing companies in United Arab Emirates (UAE) and to propose a process to evaluate the competitive priorities of these companies.Design/methodology/approach– This research is designed by composing multi criteria decision making of KM attributes in order to identify competitive priorities of large and small manufacturing companies to achieve better customer focus. To deal with this complexity of multi criteria decision-making process, Analytical Hierarchical Process (AHP) method has been used in this research.Findings– Results show that large manufacturing companies are putting more emphasis on “Know-Why” knowledge attribute in all four competitive priorities for achieving customer focus. While, small size manufacturing companies put higher weight on “Know-What” knowledge attribute by focussing on two competitive priorities (flexibility and quality).Research limitations/implications– Results are derived from a limited number of empirical data only in one country, therefore these cannot be generalized. Future research with larger samples of small and large manufacturing firms from other countries is needed.Practical implications– To be competitive, manufacturing companies must reshuffle their production strategies to allow them to play a role in global knowledge-intensive market. Therefore, they must incorporate knowledge attributes as a way to achieve higher levels of performance.Originality/value– This study is among the first and most exhaustive ones carried out in the small and large size firms operating in the manufacturing sector of UAE. It provides a systematic approach to identify the operational competencies and knowledge attributes being followed by large and small manufacturing companies.