bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Accuracy of Ultrasonography and Biopsy Necessity in the Management of Breast Lumps in Women Less than 40 Years
Authors: Itanyi Ukamaka Dorothy , Chukwuegbo James Nwabueze , Okafor Ugochukwu Egbunike , Richard Samuel Kelechi , Yawe King-David Terna 
Published: July 2024

AbstractBackground:Following recommended guidelines, palpable breast lumps in young women should be subjected to clinical–radiologic evaluation and tissue diagnosis where necessary. However, in our local practice, most benign breast lumps are also subjected to excision biopsy. Ultrasonography is the modality of choice in the evaluation of palpable breast lumps in young women.Aim:This study aims to determine the accuracy of ultrasonography and the necessity of tissue biopsy in the management of palpable breast lumps in women less than 40 years of age and to determine lesions that can safely be managed conservatively based on histological diagnosis.Materials and Methods:This was a prospective cross-sectional study of 87 adult females who had breast US and biopsy for palpable breast lumps in a tertiary healthcare center over a period of 10 months (July 2020–May 2021).Results:The age range of the women was 18–39 years (mean 27.9 ± 7.09 years).Benign lesions were noted in 86.2% of patients. No malignancy was detected in women < 25 years. Ultrasonography had sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 100%, 93.4%, 70.6%, 100%, and 94.3%, respectively, in differentiating benign from malignant breast lumps following tissue diagnosis.Conclusion:Ultrasonography and tissue biopsy are vital in the evaluation of breast lumps in women less than 40 years of age. Most (86.2%) of the lumps were benign, and no malignancy was detected in women < 25 years. The high accuracy of ultrasonography in distinguishing benign from malignant lesions suggests the need for conservative management of benign lumps in young women.
Assessment of Body Image Perception and Quality of Life of Breast Cancer Patients Accessing Care at the University College Hospital, Southwest Nigeria
Authors: Sarimiye F , Folasire A , Asuzu CC 
Published: July 2024

Background:
Breast cancer is the most prevalent cancer type globally. The female breasts are important for beauty and sexuality, comprising the body image, which includes the individual self-perception and others. This varied perception may influence the quality of life of individuals with breast cancer.

Aim:
To assess the body image perception and quality of life of breast cancer patients accessing care at the University College Hospital Ibadan.

Methods:
Eligible female adults (18 years and above), with a confirmed histologic diagnosis of breast cancer participated in this study after obtaining informed consent. The participants were without other debilitating conditions and had access to care for at least 12 months. We used a questionnaire to collect information on body image perception and quality of life (QoL) from all the participants. Data were analyzed using descriptive and inferential statistics.

Results:
One hundred sixty (160) female participants were recruited, with 74.38% having been diagnosed with breast cancer for 3 years or more, and 84.38% of them detected abnormality during breast self-examination. Over 50% of the participants had negative body image perceptions. Educational level, social/family well-being, and physical well-being were significantly associated with the QoL. There was a three-fold increase in the social and family well-being subscale score among participants with higher education levels.

Conclusion:
Negative body image results in poorer QoL in breast cancer patients, and this underscores the importance of addressing body image concerns as part of comprehensive care for breast cancer patients.
Predictors of Time to Return to Work Following Surgical Reconstruction of Upper Limb Injuries in a Cosmopolitan City in Western Nigeria
Authors: Michael AI , Isamah CP , Ugwu IC 
Published: July 2024

Background:
The management of upper limb injury is aimed at a timely return to work, and other activities of daily living. The modified hand injury severity score (MHISS) has been found to predict a return to work. Upper limb injuries are common in our subregion, but there is little or no data on the time to return to work.

Aim:
This study, therefore, aimed to determine the prevalence of return to work and to identify the predictors of time to return to work following reconstruction of upper limb injuries.

Method:
This was a cross-sectional analytic study carried out between April 2022 and March 2023. The statistical test was at a confidence interval of 95%, and statistical significance set at a P value of <0.05.

Result:
A total of 49 upper-limb-injured patients had reconstruction in the time under review. Male-to-female ratio was 4.4:1. The mean MHISS was 87.9 ± 79.2. Of the 43 patients who participated in the return-to-work analysis, 41.9% had returned to work, with a mean time of 14.3 ± 10.5 weeks. Work-related injuries (r = 0.357, P = 0.019), male gender (r = 0.354, P = 0.020), and MHISS (r = 0.333, P = 0.029) correlated significantly with late return to work. On multiple logistic regression, work-related injuries (β =0.321, P = 0.037), MHISS (β =0.376, P = 0.032), and male gender (β =0.326, P = 0.044) were found to be the significant predictors of late return to work.

Conclusion:
There is a low prevalence of return to work, with a high mean time to return. Work-related injuries, MHISS, and male gender are significant predictors of time to return to work.
Fucoidan Inhibits Prostate Cancer Growth Through Modulation of Different Cell Deaths
Authors: Tutuncu M , Sanlav G , Aktaş S , Yilmaz O , Altun ZS 
Published: July 2024

Background:
Docetaxel (DOC) is the main chemotherapeutic agent for the treatment of advanced metastatic prostate cancer. Docetaxel shows anticancer effects by preventing the depolymerization of microtubules in the cell, therefore preventing cell division. However, the low survival effect of docetaxel has prompted researchers to search for novel therapeutic agents. Fucoidan (FUC) is a sulfated polysaccharide derived from brown algae. It has many bioactivities which makes fucoidan a promising anticancer agent. In this study, the potential anti-tumorigenic and preventive effects of fucoidan with or without docetaxel in prostate cancer were investigated by analyzing different cell death modalities.

Methods:
The in-vivo six groups (n = 8) were conducted; preventive (Pt), docetaxel treated after preventive (Pt-D), control, fucoidan (FUC), docetaxel (DOC), and FUC and DOC (FUC+DOC) combination. Apoptotic, necroptotic, and autophagic cell death-related protein expressions were assessed in tumor tissues by using immunohistochemical staining. Oxidative stress-related lipid peroxidation, glutathione peroxidase, and glutathione levels were also determined in tumor tissues.

Results:
Although apoptotic, necroptotic, and autophagic cell deaths were significantly induced in agent-treated groups compared to the control. Apoptotic cell death was more significantly induced in FUC and FUC+DOC-treated groups. Necroptotic cell death was increased considerably by inducing MLKL protein expression in all treatment groups. In the FUC, Pt, and DOC groups, LC3A/B expressions were significantly increased. DOC, FUC+DOC, and Pt-D treatments caused a significant increase in Beclin-1 expression. Oxidative stress-related MDA, GPX, and GSH levels significantly decreased with FUC treatment. The anti-tumorigenic effects of FUC and DOC were also demonstrated through tumor size reduction.

Conclusion:
According to the findings of this study, FUC inhibited tumor growth temporally and dimensionally, especially in preventive applications. FUC and FUC+DOC combinations in both treatment groups showed anti-tumorigenic effects. The results of this study suggest that fucoidan is a promising anticancer agent against prostate cancer. FUC can be considered as a preventive or treatment agent in prostate cancer therapy with DOC. Further studies are needed to fully elucidate the mechanism of action of fucoidan in metastatic prostate cancer.
Prevalence and Pattern of Tooth Impaction: A Radiographic Study in a Trinidadian Population
Authors: Naraynsingh CN , Henry K , Hunte R , Ramlogan N , Bissoon A 
Published: July 2024

Objective:
The aim of this retrospective study was to determine the prevalence and patterns of impacted third molars in a Trinidadian population.

Methods:
A total of 1500 orthopantomograms (OPG) taken at the School of Dentistry, University of the West Indies, from 2008 to 2019 in patients between 15 and 67 years old were evaluated. From the data collected, the prevalence of third molar impaction, the parameters of gender, angulation, level of impaction, and associated pathologies were evaluated. Other types of impacted teeth were also recorded.

Results:
Of the 1500 OPG viewed, 408 (27.2%) of the study sample presented with at least one impacted third molar. 161 (39.5%) were males and 247 (60.5%) were females, with a male-to-female ratio of 1:1.5. There was a greater incidence of mandibular third molars versus maxillary third molars, which had a frequency of 77.9% and 22.1%, respectively. The most common type of impaction (Winter’s classification) was horizontal in the mandible and distoangular in the maxilla. The most common level of impaction in the mandible (Pell and Gregory classification) was level 1A. The total number of impacted teeth was 775, and of these, 75 (9.7%) showed other impacted teeth besides the third molars. Canines and second premolars were the most prevalent with 7.6% and 1.5%, respectively. Caries on the second molar (49.3%) and third molars (40%) were the most frequently associated pathologies identified.

Conclusion:
The prevalence of impacted wisdom teeth in this study was 27%. These results raise awareness and provide insight among dental professionals in Trinidad as to the prevalence of impacted third molars, their patterns, as well as commonly associated pathologies, and the need for screening within the population.
Granulomatosis with Polyangiitis: A Rare but Clinically Important Disease for the Otolaryngologist
Authors: Webb H , Toppi J , Fairley J , Phillips D 
Published: July 2024

Introduction:
Granulomatosis with polyangiitis (GPA) is rare but debilitating autoimmune disease and commonly presents with sinonasal as well as other head and neck symptoms.

Aims:
To summarize the ear, nose, and throat-specific symptomatology and management of GPA.

Methods and Results:
We performed a literature review by using the PubMed search engine to provide a summary of recent and important literature that is pertinent to an otolaryngologist’s clinical practice. We provide a guide on the pathophysiology, epidemiology, clinical features, investigation, and management (operative and nonoperative) of this important disease.

Conclusions:
This review illustrates the important role that an otolaryngologist can play in the work up and symptom management of patients with GPA. Knowledge of the common presenting symptoms as well as more rare presentations of GPA is extremely important for otolaryngologists as prompt diagnosis and management is extremely important to avoid significant morbidity and mortality.
Analyzing the Relationships between State School Policies and Absenteeism Rates for 9-12th Grade Students in Texas-Mexico Border Districts
Authors: Gallegos Gabriela Angelina , Schaper Kylie , Roy Sharmily , Gao Jingjing 
Published: July 2024

Chronic absenteeism can impact high school students’ long- and short-term development, especially in socio-economically challenged areas such as the Texas-Mexico border. We aimed to identify effective public school absenteeism policies and provide a roadmap for further investigation and state policy advocacy. This study analyzed four district-level school absenteeism policies in 88 public school districts along the Texas-Mexico border: requiring parental notification after one absence, offering incentives for student attendance, assignment of a Truancy Prevention Facilitator, and punishing students for absenteeism. District policies were collected through a review of district websites, student handbooks, codes of conduct, District Improvement Plans, and District of Innovation Plans. The chronic absenteeism and emergent bilingual/English learner (EB/EL) absenteeism rates reported in Texas Education Agency Texas Academic Performance Reports for grades 9-12 were utilized as attendance indicators. Hierarchical linear modeling, an ordinary least square regression-based analysis, was used to examine association relationships between the policies as independent variables and absenteeism rates as the dependent variables. School districts that do not offer attendance incentives and assign officers as truancy prevention facilitators have the highest predicted total chronic absenteeism rate; districts that do not offer attendance incentives and assign support services personnel as truancy prevention facilitators have the highest predicted EB/EL absenteeism rate. Districts with attendance incentives also are associated with higher EB/EL absenteeism. Identifying effective school policies to reduce chronic absenteeism will help districts better tailor the implementation of state policies and promote access to education and services.
Hubungan Kadar Glukosa Darah Puasa dengan Kadar Trigliserida dalam Darah
Authors: Christyawardani Lidwina Septie , Haiti Margareta 
Published: July 2024

Kadar glukosa darah yang tinggi memiliki potensi mengganggu metabolisme lipid dengan mengakibatkan peningkatan tingkat kolesterol total, trigliserida (TG), low density lipoprotein (LDL), dan penurunan high density lipoprotein (HDL). Jika tingkat trigliserida dalam aliran darah terus meningkat, ini disebut hipertrigliserida, dan ini dapat menyebabkan aterosklerosis. Penelitian ini bertujuan untuk mengetahui bagaimana kadar glukosa darah dan tingkat trigliserida dalam aliran darah berhubungan satu sama lain. Peneliti melihat dan menganalisis pengaruh variabel independen terhadap variabel dependen dalam penelitian ini. Jenis penelitian yang digunakan adalah desain observasional analitik dimana sampel yang digunakan adalah mahasiswa D IV Teknologi Laboratorium Medis Fakultas Ilmu Kesehatan UKMC. Data yang diperoleh dianalisis menggunakan uji korelasi spearmen’rho Tidak ada korelasi yang signifikan antara kedua variabel yang diteliti, seperti yang ditunjukkan oleh analisis hubungan antara konsentrasi glukosa dalam darah dan trigliserida, dengan nilai p=0,842. Penelitian ini menunjukkan bahwa tidak ada korelasi yang signifikan antara variabel.
Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells
Authors: Kulinich T. M. , Kiseleva Ya. Yu. , Shishkin A. M. , Kudinova E. A. , Knyazeva O. B. , Ranjit R. , Bozhenko V. K. , Solodky V. A. 
Published: July 2024

Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific to the CA125 antigen in relation to both CA125-positive and CA125negative cell cultures.Materials and methods. We performed an in vitro study on CA125-positive human ovarian cancer cells (OVCAR-3, OVKATE) and CA125 negative cells (breast cancer MCF 7, embryonic kidney HEK293). Cytotoxic effects on tumor cells were evaluated after 0, 4, 8 and 24 hours using the 3’-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and Lactate Dehydrogenase (LDH) tests. We also studied the changes in the number of cells “in real time” when exposed to transfected lymphocytes using the RTCA iCELLIgence device (ACEA Biosciences, USA). Lymphokineactivated killer (LAK) cells were used as a specificity control.Results. The study demonstrated that anti-CA125 CAR-T lymphocytes exhibited a pronounced cytotoxic effect on OVCAR-3 and OVKATE cell cultures, exceeding the effect of LAK by 1.3 times. The cell population in the experimental samples decreased by 70 ± 4%, which exceeded the LAK effect by 9 ± 8.2%. With regard to the MCF-7 cell line, the cytotoxic effect of anti-CA125 CAR-T lymphocytes was minimal as evidenced by a 25.8% decrease in the relative number of live cells in comparison to the LAK cytotoxicity of 68%. Real-time monitoring of cell proliferation and viability proved a high specific cytotoxic effect of anti-CA125 CAR-T lymphocytes against tumor cultures expressing CA-125, while inferior to LAK in cultures not expressing CA125 (MCF-7, HEK293).Conclusions. The use of anti-CA125 CAR-T lymphocytes against CA125-positive tumor cell lines OVCAR-3 and OVKATE demonstrated a pronounced specific cytotoxic effect exceeding the cytotoxic effect of LAK, which was not achieved against CA125-negative MCF-7 and HEK293 cells.
Fatty acid composition of blood serum and erythrocyte membranes in men with steatosis and steatohepatitis with normal transaminase activity
Authors: Kruchinina M. V. , Osipenko M. F. , Shestov A. A. , Parulikova M. V. 
Published: July 2024

Aim. To study the characteristics of the fatty acid (FA) profi le of blood serum and erythrocyte membranes in patients with two forms of fatty liver disease (metabolic + alcoholic): steatosis and steatohepatitis with normal transaminase activity.Materials and methods. We examined 33 men (50.7 ± 9.6 years) with fatty liver disease (metabolic and alcoholic) with fi brosis F ≤ 1 (FibroTest). According to the ActiTest results, patients were divided into groups of steatosis – with minimal (A0–1) activity (n = 17) and steatohepatitis – with moderate/severe (A2–3) necroinfl ammatory activity (n = 16). The FA composition of blood serum and erythrocyte membranes was studied using gas chromatography/mass spectrometry Agilent 7000B (Agilent Technologies, Inc., USA). Methods of unpaired statistics using volcano plot and discriminant analysis based on orthogonal least squares (Orthogonal Partial Least Squares Discriminant Analysis, OPLS-DA), ROC analysis were applied.Results. Volcano plot analysis showed that in patients with fatty liver disease (metabolic and alcoholic) with normal transaminase activity, serum levels of stearic C18:0 (p = 0.016), arachidic C20:0 (p = 0.023), ratio saturated / polyunsaturated fatty acids (PUFA) (p = 0.001) were statistically signifi cantly higher in the steatohepatitis group compared with the steatosis group. The total content in the blood serum of all PUFA (p = 0.003), margaric C17:0 (p = 0.011), the sum of two omega-3 PUFA – eicosapentaenoic acid (C20:5n-3) and docosahexaenoic acid (C22:6n-3) (p = 0.04), the total content of all omega-3 PUFA (p = 0.042) were statistically signifi cantly lower in patients with steatohepatitis. OPLS-DA demonstrated fairly accurate separation of steatohepatitis and steatosis using individual FA and their ratios. When individual FA and their ratios were included in the analysis, a model was obtained with AUC = 0.827 (95% confi dence interval 0.499–1.0), sensitivity 82.2% and specifi city 80.7%.Conclusion. FA in blood serum and erythrocyte membranes appear to be promising biomarkers of steatohepatitis with normal levels of transaminases.
The “Whole” in Our Holiness: New Covenant Wholeness in James 1
Authors: Baker Mark H. 
Published: July 2024

Abstract
This article argues that the new covenant promises in Jer 31:31–34 and Isa 52:11–54:17 stand as key theological antecedents to Jas 1. This background informs the author’s meaning of the concept of wholeness. This “new covenant wholeness” connects the central themes in the chapter: Steadfastness through travails produce wholeness (1:4). God’s wholeness is put on display as he gives “generously” to all (1:5), and his gifts are “whole” (1:17). New covenant members have received the “implanted word” (1:21) and show no division between faith and action through their meditation on the “perfect law of liberty” (1:25).
Dampak Penggunaan Media Sosial Facebook Bagi Ibu Rumah Tangga
Authors: Sinta Dwi Ramadhani  , Tiara Indri Astuti  , Andhita Risko Faristiana  
Published: July 2024

Facebook is one of the most used social media platforms. Facebook offers a variety of features, including status updates, photos, videos, user-generated content, and even a user-to-user marketplace. The trend of appearing on social media is currently dominated by housewives. This study aims to This research aims to find out the social media that is often used by housewives ladder. the average duration of using social media and knowing their opinions about the use of social media. Data collection is done through literature study, interviews. The purpose of this study is: To find out what features are most often used by housewives in using Facebook social media, To find out the impact of using Facebook social media among housewives Changes in the behavior of respondents using Facebook among housewives The impact of the use of Facebook social media consists of 2 impacts, namely positive and negative impacts. Positive impacts include: As household harmony, entrepreneurial development, online business. Negative impacts include: Abandoned household affairs, fraud and disputes.

Housewives
Perbandingan Pengembangan Sistem Dengan Pendekatan Konvensional dan Low-Code Pada Sistem Pendukung Keputusan Penilaian Kinerja Pegawai
Authors: Carissa Maharani Chandra  , Muhammad Rachmadi  
Published: July 2024

PT XYZ is a company engaged in the supply of materials, suppliers, and services, especially in the field of electrical equipment, such as generators, mechanical devices, electrical devices, cables, electricity meters, and so on. The company has a total of 26 employees, all of whom are permanent employees. This company has assessed employee performance every month, but it is done using narratives so it is still subjective and there is no ranking. This is certainly very difficult for HR staff in determining the best employees every month. The purpose of this Employee Performance Assessment Decision Support System design is to improve accuracy and efficiency in calculating employee performance to determine the best employees. In this research, the system development method used is the Rational Unified Process (RUP). This system development also uses two main approaches, which are low- code approach (OutSystems platform) and conventional approach (Laravel framework). From the development using the RUP method, it can develop a Decision Support System for Employee Performance Assessment for PT XYZ.
Analisis Audit Sistem Informasi Menggunakan Framework Cobit 5 Pada E-Learning (Studi Kasus : Universitas XYZ)
Authors: Putra Djoelham Sembiring  , Boyke Gunawan Manurung  , Win Gomgom Parsaulian Sirait  
Published: July 2024

In the era of globalization, information technology is growing rapidly in Indonesia. Globalization is a worldwide integration process that encompasses many aspects of life and is characterized by openness, creativity, sophistication, speed, commitment, excellence, strength and free competition. Education as a field of human resource development requires the integration of modern science and technology to transform tacit knowledge gained from direct experience and create explicit knowledge that creates new, sophisticated, and competitive products. As an educational institution, XYZ University has implemented information technology to support academic activities such as e-learning service.