bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dexmedetomidine ameliorates diabetic intestinal injury by promoting the polarization of M2 macrophages through the MMP23B pathway
Authors: Lu Man , Guo Xiao-Wen , Zhang Fang-Fang , Wu Dan-Hong , Xie Di , Luo Feng-Qin 
Published: August 2024

BACKGROUND
Diabetes is often associated with gastrointestinal dysfunctions, which can lead to hypoglycemia. Dexmedetomidine (DEX) is a commonly used sedative in perioperative diabetic patients and may affect gastrointestinal function.
AIM
To investigate whether sedative doses of DEX alleviate diabetes-caused intestinal dysfunction.
METHODS
Sedation/anesthesia scores and vital signs of streptozotocin (STZ)-induced diabetic mice under DEX sedation were observed. Diabetic mice were divided into saline and DEX groups. After injecting sedatives intraperitoneally, tight junctions (TJs) and apoptotic levels were evaluated 24 hours later to assess the intestinal barrier function. The role of DEX was validated using Villin-MMP23B flox/flox mice with intestinal epithelial deletion. In vitro , high glucose and hyperosmolarity were used to culture Caco-2 monolayer cells with STZ inter-vention. Immunofluorescence techniques were used to monitor the barrier and mitochondrial functions.
RESULTS
MMP23B protein levels in the intestinal tissue of STZ-induced diabetic mice were significantly higher than those in the intestinal tissue of control mice, with the DEX group displaying decreased MMP23B levels. Diabetes-mediated TJ dis-ruption, increased intestinal mucosal permeability, and systemic inflammation in wild-type mice might be reversed by DEX. In Caco-2 cells, MMP23B was associated with increased reactive oxygen species accumulation, mitochondrial membrane potential depolarization, and TJ disruption.
CONCLUSION
DEX reduces MMP23B, which may potentially contribute to STZ-induced intestinal barrier dysfunction, affecting TJ modification through mitochondrial dysfunction.
Motivation, Cues to Action, and Barriers to COVID-19 Vaccine Uptake: A Qualitative Application of the Health Belief Model among Women in Rural Zambia
Authors: Kuhfeldt Kayla J. , Kaiser Jeanette L. , Morgan Allison J. , Ngoma Thandiwe , Hamer Davidson H. , Fink Günther , Rockers Peter C. , Chirwa Benson , Scott Nancy A. 
Published: August 2024

ABSTRACT.
Vaccine hesitancy has played a major role in slowing the global COVID-19 response. Using cross-sectional, primarily qualitative data collected in four rural districts in Zambia, we aimed to explore community perceptions of COVID-19 disease and vaccines, including perceived motivators, cues to action, benefits, and barriers to vaccine uptake as guided by the Health Belief Model. In-depth interviews (IDIs) were conducted in late 2021 with women of reproductive age who were enrolled in an early childhood development study. Although two-thirds of the 106 respondents reported low perceived risk of catching COVID-19, they expressed concern that the COVID-19 pandemic had impacted their daily lives and feared effects of the disease. They had generally positive beliefs that the vaccine would be accepted among their communities when it became more widely available. Reported motivators to vaccine uptake included desire for protection against COVID-19 and understanding vaccine purpose, due to ongoing education from health personnel, neighbors, friends, radio, and church leaders. Misinformation or reported bad experiences served as cues away from vaccine uptake. Examples of misinformation included the vaccine causing COVID-19 or another disease and death and vaccines being associated with the devil and against Christian beliefs. Accounts of pain after receiving the vaccine also discouraged uptake. Perceived benefits included a desire to be protected from the disease, belief in the effectiveness of the vaccine, fear of catching COVID-19, and belief the vaccine would limit negative effects. Health system implementers and policy makers should consider recipient motivators and cues to action to further increase vaccination rates.
Visceral Leishmaniasis in Sub-Himalayan India (1967–2023): A Systematic Review
Authors: Mewara Abhishek , Satapathy Prakasini , Dhatwalia Sunil Kumar 
Published: August 2024

ABSTRACT.
Substantial gains have been achieved in the control of visceral leishmaniasis (VL) in the four endemic states of India; however, cases are sporadically reported from other nonendemic regions of India such as the sub-Himalayan region, which can be a hurdle to VL elimination. We analyzed VL reports published from the sub-Himalayan regions of India over seven decades (1967–2023) in this systematic review. Medline, Embase, Scopus, and Web of Science were searched for VL cases from sub-Himalayan regions of India. The demographic data, clinical presentation, diagnostic modality, treatment, outcomes of the cases, and overall year-wise and geographical distribution of the cases were analyzed; studies on the sand fly vector were also included. From 535 articles, 33 studies were included in the analysis. Overall, 228 patients were diagnosed with VL in the sub-Himalayan region of India from 1967 to 2023. These cases were reported from Uttarakhand (n = 178), Himachal Pradesh (n = 39), and Jammu and Kashmir (n = 11). Most patients (88.4%) did not have a history of travel outside their native places. Three pediatric cases were reported from Jammu and Kashmir. The DNA of Leishmania donovani was detected in four of the 52 (7.7%) sand flies collected from Himachal Pradesh. The published literature points toward the existence of local transmission of VL in the sub-Himalayan region of India, strongly substantiated by the emergence of pediatric VL in some places. Thus, these difficult-to-reach hilly states of India will require focused surveillance for VL to successfully achieve elimination goals.
Pelatihan dan Pedampingan Pembuatan Media Pembelajaran bagi Para Guru di SMK N 1 Sambirejo
Authors: Srirahayu Agustina , Tominanto Tominanto , Suryono Afif 
Published: August 2024

SMK Negeri 1 Sambirejo memiliki 5 jurusan dan memiliki jumlah guru sebanyak 71 orang. Pelatihan dan pedampingan pembuatan media pembelajaran untuk menjadi langkah pertama dalam upaya meningkatkan mutu dan kualitas media pembelajaran di SMK Negeri 1 Sambirejo. Pelatihan dan pendampingan media pembelajaran mempunyai dampak positif yaitu dapat menyampaikan pelajaran menjadi lebih baku, menarik dan interaktif. Beban guru untuk menyampaikan materi menjadi berkurang karena tidak lagi menyampaikan secara berulang. Materi pelatihan yang disajikan dalam pelaksanaan pengabdian ini yaitu : Pengantar Desain Komunikasi Visual, Prinsip-prinsip Desain Grafis, Teknik Pemilihan Warna yang Efektif, Penggunaan Tipografi dalam Desain, Pemanfaatan Visualisasi Data dalam Media Pembelajaran, dan Pengenalan Software Desain Grafis (opsional). Kegiatan pendampingan pembuatan Google Form, Multimedia Interaktif dan Video Pembelajaran berjalan dengan baik dan antusias guru yang sangat besar dalam mengikuti kegiatan ini. Tujuan pelaksanaan dan solusi yang ditawarkan dalam kegiatan pelatihan dan pedampingan pembuatan media pembelajaran bagi Guru di SMK N 1 Sambirejo yaitu : (1) Meningkatkan pemahaman guru tentang media pembelajaran, (2) Memberikan keterampilan kepada guru dalam merancang media pembelajaran yang menarik dan efektif, dan (3) Mendorong guru untuk mengintegrasikan prinsip-prinsip Desain Komunikasi Visual dalam kegiatan pembelajaran mereka. Semoga kegiatan ini dapat memberikan manfaat yang besar bagi pengembangan pendidikan di SMK Negeri 1 Sambirejo. Disarankan agar dilakukan pelatihan lanjutan yang lebih mendalam mengenai kegiatan belajar mengajar dengan pemanfaatan media pembelajaran
The kynurenine pathway in patients with rheumatoid arthritis during tumor necrosis factor α inhibitors treatment
Authors: Witoszyńska-Sobkowiak Joanna , Sikorska Dorota , Niklas Karolina , Żychowska Iwona , Rutkowski Rafał , Samborski Włodzimierz 
Published: August 2024

ObjectivesThe importance of the kynurenine pathway in normal immune system function has led to an appreciation of its possible contribution to autoimmune disorders such as rheumatoid arthritis (RA). The aim of the study was to evaluate the effect of treatment with tumor necrosis factor α (TNF-α) inhibitors on the activity of the kynurenine pathway in patients with RA.Material and methodsThis was an investigator-initiated, prospective, observational study. The study was performed on 30 RA patients (Caucasian, 11 male, 19 female; mean age 45 ±16 years) treated with TNF-α inhibitors. All patients were assessed before and after 6 months of therapy.
As a control group, age- and sex-matched, 20 healthy volunteers were recruited. Disease activity was evaluated by the Modified Disease Activity Score with 28-joint count (DAS28). Inflammatory markers were assessed routinely by the hospital central laboratory. Serum concentrations of kynu­renine, serotonin and tryptophan were measured with specific immunoassays. To estimate indoleamine 2,3-dioxygenase (IDO) activity, kynurenine-to-tryptophan ratio was calculated.ResultsThe results of our study showed changes in tryptophan metabolism in RA patients, compared with healthy controls. Surprisingly, RA patients had statistically significant decreased kynu­renine-to-tryptophan ratio (p = 0.003), which could indicate diminished IDO activation in RA. Moreover, we found no significant changes in kynurenine-to-tryptophan ratio after treated with TNF-α inhibitors (p = 0.490), despite disease remission. Additionally, tryptophan metabolism activity did not correlate with objective markers of inflammation.ConclusionsThe RA patients had altered tryptophan metabolism, compared with healthy controls. The mechanisms affecting tryptophan metabolism in RA may be complex. We believe that continuing elucidation of pathophysiological pathways relevant in RA offer substantial hope for the development of specific pharmacotherapy for treatment of RA – especially for comorbidity of RA and depression.
Model Aplikasi Sistem Pendaftaran Pasien Berbasis Web Pada Emotion Theraphy Clinic Grahita Psychologic Garut
Authors: Wijayanti Diah , Haryadi Eko , Azizah Nurul , Widyastuti Indria 
Published: August 2024

Perkembangan zaman ini bukan hanya berpengaruh terhadap teknologi informasi namun juga diimbangin dengan tingginya mobilitas masyarakat, hal ini membuat seseorang makin mengembangkan sumber daya manusia. Keadaan sosial yang makin kompetitif menuntut masyarakat umum memiliki spesifikasi personal yang lebih tinggi dikarenakan makin bervariasinya emosi, karakter hingga personality karena itu maka dibutuhkan Lembaga psikologi terapan guna menjadi pengembang sumberdaya manusia serta memperbaharui emosi. Grahita Indonesia merupakan suatu perusahaan yang bergerak dibidang klinik serta laboratorium psikologi projektif terapan dan memiliki beberapa sentra pelayanan psikologi lainnya.Salah satunya di garut yang biasa disebut Grahita psychologic. Sistem yang ada sekarang Ini masih merupakan web company profile yang belum bisa dimanfaatkan oleh pasien untuk pendaftarannya maupun pemeriksaan. Para pasien masih mendaftar secara manual yaitu datang langsung ke klinik Grahita psychologic, Dengan adanya permasalahan tersebut maka di buat lah suatu sistem informasi mengenai pendaftaran berbasis web pada Emotion Theraphy Clinic Grahita Psychologic Garut, yang dapat mempermudah pasien dalam berobat di klinik grahita psychologic. Dalam hal ini metode waterfall dipilih sebagai meode penelitian Dan hasil pengujian yang dilakukan melalui black box testing. Hasil pengujian ini di fokuskan pada proses input dan output program. Dimana hal ini dilakukan untuk untuk melihat adakah kesalahan ataupun kekurangan dari program tersebut. Selain itu juga untuk mengetahui apakah sesuai dan harapan program telah berjalan dan melihat apakah semua kebutuhan fungsional berjalan dengan baik dan benar. Hasil dari penelitian ini adalah berupa aplikasi sistem pendaftaran pasien secara online atau berbasis web yang diharapkan dapat memudahkan admin dalam proses pengolah data pasien pada klinik Emotion Theraphy Clinic Grahita Psychologic Garut.
PELATIHAN DAUR ULANG SAMPAH UNTUK MENINGKATKAN EKONOMI KREATIF SISWA-SISWI MA SRIWIJAYA
Authors: Afifah Pipit , Rahman Wahid Moh. Abdur , Pertiwi Kartika Eka 
Published: August 2024

Kelestarian lingkungan merupakan upaya untuk menjaga dan memelihara lingkungan agar tetap berfungsi untuk mempertahankan kelangsungan hidup masyarakat.perubahan lingkungan juga dapat mempengaruhi beberapa aspek kehidupan, perubahan yang terjadi pada lingkungan hidup dapat menjadi penyebab terjadinya lingkungan kurang berfungsi. Oleh karena itu, masyarakat dituntut untuk menjaga atau memelihara kelestarian. Tujuan program Pengabdian Kepada Masyarakat (PKM) ini adalah . Mendeskripsikan bentuk kegiatan pengelolaan sampah Organik Dan anorganik menjadi aneka kreasi daur ulang pada Siswa-Siswi MA Sriwijaya. Target khusus untuk memberikan mampu mengolah bahan bekas atau sampah menjadi bahan produk yang lebih kreatif dan meningkatkan ekonomi dan mampu membuka peluang lapangan kerja. Metode yang digunakan dalam pengabdian ini adalah metode service learning. Hasil dari pelatihan ini siswa dapat mendaur ulang sampah dan diajadikan produk yang lebih kreatif. Selain itu dengan adanya kegiatan ini dapat mengurangi atau memanfaatkan limbah sampah.
Theoretical Aspects of Transdisciplinarity in Telerehabilitation
Authors: Malakhov Kyrylo S. , Kotlyk Sergii V. , Petrenko Mykola G. 
Published: August 2024

This article explores the theoretical aspects of transdisciplinary research, with a specific focus on its application to telerehabilitation. The integration of multiple disciplines – ranging from medicine, digital health, and informatics to engineering and the social sciences – is increasingly necessary to address the complex challenges of delivering effective remote rehabilitation services. The article begins by outlining the conceptual framework, distinguishing between disciplinary, interdisciplinary, multidisciplinary, and transdisciplinary approaches, and highlighting the importance of transcending traditional disciplinary boundaries.
The theoretical foundations discussed provide a basis for understanding how the convergence of diverse fields can lead to innovative solutions in telerehabilitation. The integration of disciplines is examined in detail, illustrating how collaborative efforts across medicine, technology, and behavioral sciences can enhance patient outcomes, improve accessibility, and foster the development of personalized rehabilitation plans. The article also covers the practical implications for clinical practice, emphasizing the need for a more collaborative model of care delivery and the potential for cost-effective, scalable solutions.
Looking toward the future, the article identifies key areas for research, including the development of advanced technologies, exploration of new therapeutic modalities, and consideration of ethical and social impacts. The need for standardization and interoperability in telerehabilitation systems is also underscored, as these will be critical to ensuring the seamless integration of various technologies and platforms.
Spatial and Seasonal Variations in the Size-Weight Relationship and Condition Index of the Mangrove Oyster Crassostrea tulipa (Lamarck, 1819) in the Saloum Delta, Senegal
Authors: Thiao Ibrahima , Houménou Abdou Karim , Tamigneaux Éric , Fall Jean , Fontaine Pierre-Olivier , Diouf Malick 
Published: August 2024

In the Saloum delta in Senegal, the mangrove oyster Crassostrea tulipa is under increasing human pressure, leading to a decline in wild stocks, a decrease in the quality of the marketed oysters and the degradation of mangrove tree roots. Previous studies have pinpointed some of these disturbances and yet, there is little information available on the structure of the population and the condition index of the species. The aim of this study was to document these aspects in order to support a sustainable management of the resource. From January 2021 to December 2022, monthly sampling was carried out at five stations to study the size-weight relationship and the condition index (CI) of oysters. A total of 26,790 individuals ranging in size from 0.23 to 93.19 mm with an average of 33.86±16.38 mm shell height were collected. The species was found to have a minority allometry (b = 2.54 <3), with a strong correlation between individual weight and oyster shell height (r = 0.88). CI showed seasonal and inter-site variations over the two years, with an overall mean value of 11.17±2.72%. The highest CI values were observed during the hot season and the lowest during the hot-cold transition period.
Középiskola-választás szempontjainak vizsgálata fenntartók, németet és angolt tanulók, valamint tanítók véleménye alapján
Authors: Sebestyén Krisztina 
Published: August 2024

Egy oktatási intézmény népszerűségét, teljesítményét az intézmény különböző jellemzői határozzák meg, például az intézmény által kínált oktatási lehetőségek, az oda bekerülő tanulók teljesítménye, versenyeztetési, tehetséggondozási, illetve felzárkóztatási tevékenységek. Mindezek a jellemzők a következő években hatással vannak arra, hogy kik és miért választják az adott intézményt, ezért érdemes megvizsgálni, hogy milyen iskolaválasztást befolyásoló tényezők alapján választják a diákok az adott oktatási intézményt. A tanárok szemszögéből azért lehet fontos az ilyen irányú vizsgálat, hogy megismerjék az általuk tanítandó diákok bázisát, motivációit.
Tanulmányunkban ezek alapján a „Némettanulás, illetve -tanítás Hajdú-Bihar és Szabolcs-Szatmár-Bereg megyében 2018-2019” című kutatás tanulói (890 fő), illetve tanári (100 fő) adatbázisa segítségével azt vizsgáljuk, hogy milyen középiskola-választási tényezők befolyásolták az adott intézményben való továbbtanulást. A tanulói eredményeket összehasonlítjuk a tanári válaszokkal, hogy megtudjuk, mennyire ismerik a tanulóikat ebből a szempontból. Az adatok vizsgálatát SPSS programmal végeztük, amely segítségével két- és háromdimenziós variancia-analízist készítettünk. Ezekhez az alábbi változókat vontuk be: tanított/tanult idegen nyelv, az intézmény fenntartója, valamint ötfokú Likert-skálán értékelt, középiskola-választásra vonatkozó állítások.
Tanulmányunkban az alábbi három hipotézist vizsgáljuk meg. (1) A nyelvtanárok válaszai megegyeznek a tanulókéval, vagyis ismerik a középiskola-választás háttérokait. (2) Az eltérő idegen nyelvet tanulók, illetve tanítók válaszai idegen nyelvenként különböznek egymástól. (3) Fenntartónként eltérő, hogy milyen tényezők befolyásolták a tanulók középiskola-választását. Eredményeink szerint az első hipotézis nem igazolódott, a második és a harmadik igen, és összességében a tanárok válaszai között kevesebb szignifikáns összefüggést találtunk, mint a tanulóknál.
PENGARUH INFLUENCER MARKETING TERHADAP MINAT BELI (STUDI PRODUK SCARLETT WHITENING)
Authors: Tiara Marlina Putri  , Koernia Purwihartuti  
Published: August 2024

Munculnya era digitalisasi modern telah berdampak besar pada bidang pemasaran. Perusahaan berlomba-lomba menunjukkan keunggulan mereka. Guna beradaptasi dengan era yang berkembang pesat ini, banyak perusahaan telah beralih ke pemasaran online sebagai strategi utama. Scarlett Whitening telah menggunakan taktik bermitra dengan influencer media sosial. Dengan memanfaatkan kekuatan pemasaran digital dan konten berkelanjutan yang disediakan oleh para influencer ini, kemungkinan besar merek tersebut akan secara langsung menarik lebih banyak pembeli untuk produknya. Pada tahun ini Scarlet mengalami penurunan penjualan di ecommerce. Penelitian ini bertujuan untuk menyelidiki kondisi serta dampak Influencer Marketing terhadap kecenderungan pembelian produk Scarlett Whitening. Penelitian ini menggunakan metode deskriptif dengan pendekatan penelitian kuantitatif rasional. Teknik pengambilan sampel menggunakan non-probability sampling. Ukuran sampel yakni 174 pelanggan sebagai responden. Alat analisis yang digunakan yaitu mean dan regresi sederhana. Dari pengujian hipotesis, ditemukan bahwa terdapat hubungan positif dan signifikan antara Influencer Marketing dan minat pembelian. Minat beli 63,8% dipengaruhi oleh influencer marketing, sedangkan sisanya dipengaruhi faktor lain. Kondisi Influencer Marketing dan minat beli konsumen produk scarlet whitening dalam kategori baik.
Software Sistem Pelaporan Akuntansi Koperasi (Silakop) Sebagai Solusi Pencatatan dan Pelaporan Keuangan Koperasi Wanita
Authors: Syaiful Hidayat Ujang , Siwidyah Desi Lastianti  , Yanna Eka Pratiwi  , Indra Wijayanto  , Ida  
Published: August 2024

This article discusses women's cooperatives, which have an important role in efforts to empower women and
help improve the welfare of their members. However, women's cooperatives face financial reporting problems and a lack of knowledge and skills in preparing financial reports in accordance with Financial Accounting Standards for Entities Without Public Accountability (SAK-ETAP). This study aims to design and develop accounting software that can provide solutions to the problems of recording and reporting finances for women's cooperatives. This action research uses a qualitative approach, carried out in the cities of Malang and Surabaya in the period October-November 2022, with data collected through interviews, observations and financial documents. The result of this research is a cooperative accounting reporting software (SiLaKop) that has been used in several KopWans in the City and Regency of Malang.
IMPLEMENTATION OF CHARACTER EDUCATION IN HISTORY LEARNING IN HIGH SCHOOL
Authors: Rahman Kholilur , Eka Rahayu  , Medani P. Bhandari  
Published: August 2024

Character education in schools, both formal and non-formal, especially inMadrasas, is considered important. However, its implementation has not been fullyrealized in the field. The aim of this research is to determine the application ofcharacter education in history learning. This research uses a qualitative methodwith a descriptive approach, the data collection techniques used by researchers inthis research are observation, and documentation. Data analysis techniques usingdomain data analysis. The research results show that character education has beenimplemented by history teachers. The implementation of character education inhistory learning at school aims to shape student character. Among the character values listed include love for Allah SWT, discipline, mutualcooperation.
Dinamika Perbankan Syariah dalam Konstelasi Hukum Nasional di Indonesia
Authors: Syaugi Syaugi , Alamaud Ichwan Anaz 
Published: August 2024

Lahirnya Sejemlah regulasi terkait perbankan syariah menjadikan titik awal penerapan bank berbasis bagi hasil yang selama ini didominasi oleh bank berbasis bunga. Upaya pemerintah dalam mengundangkan sejumlah Undang-Undang terkait perbankan, setidaknya sebagai usaha pemerintah dalam aspek instrumental hukumnya. Ada 3 (tiga) aspek yang diharapkan yaitu pertama, regulasi harus mampu mendukung kegiatan operasional perbankan syariah yang sehat dan sesuai dengan karakteristik operasionalnya. Kedua, regulasi harus mampu mendorong perkembangan bank syariah di masa depan.. Ketiga, regulasi harus mampu memberi landasan dan menjawab ketiadaan institusi-institusi pendukung yang diperlukan bagi industri perbankan syariah