bluuebunny/crossref_metadata_2025_split huggingface dataset:
The electrical properties and in vitro osteogenic properties of 3D‐printed MgO@BT/HA piezoelectric ceramic disk
Authors: Chen Kai , Qin Zhenyao , Zhang Mingjun , Wang Lin , Zheng Shikang , Wang Yingtong , Chen Chuang , Tang Haoyu , Zhong Yuhao , Yang Hongxuan , Wu Guomin 
Published: July 2024

AbstractThe repair of bone defects from various causes remains a significant challenge in clinical settings. Piezoelectric materials have been demonstrated to promote osteogenic differentiation, among which barium titanate (BT) has been widely reported. Magnesium oxide (MgO) dopants not only enhance the piezoelectric properties but also stimulate the osteogenic and angiogenic properties in stem cells. In this study, a MgO‐modified BT/hydroxyapatite (MgO@BT/HA) piezoelectric ceramic scaffold was constructed using three‐dimensional (3D)‐printed technology. The results indicated that the addition of MgO improved the electrical properties of BT (d33 = 68.26 pC/N), and facilitated an increase in the proportion of HA (30%) while maintaining the piezoelectric coefficient (d33 = 2.04 pC/N) of the ceramic system. Furthermore, under the induction of low‐intensity pulsed ultrasound (LIPUS) stimulation, in vitro biosafety experiments confirmed that MgO@BT/HA exhibits excellent biosafety and promotes the osteogenic differentiation of dental pulp stem cells (DPSCs).
Molecular profile of vestibular compensation in the medial vestibular nucleus after unilateral labyrinthectomy
Authors: Wang Jun , Liu Dan , Tian E. , Zhang Yuejin , Guo Zhaoqi , Chen Jingyu , Guo Jiaqi , Zhou Zhanghong , Shi Shiyu , Lu Yisheng , Zhang Sulin 
Published: July 2024

AbstractLong non‐coding RNAs (lncRNAs) have emerged as crucial regulators in the central nervous system, yet their role in vestibular compensation remains elusive. To address this knowledge gap, we employed unilateral labyrinthectomy (UL) in rats to establish animal models of peripheral vestibular dysfunction. Utilizing ribonucleic acid sequencing (RNA‐seq), we comprehensively analysed the expression profiles of genes dysregulated in the medial vestibular nucleus (MVN) of these rats at distinct time points: 4 h, 4 days, and 14 days post‐UL. Through trans‐target prediction analysis integrating differentially co‐expressed messenger RNAs (mRNAs) and lncRNAs, we constructed lncRNA‐mRNA regulatory networks. Validation of selected mRNAs and lncRNAs was performed using RT‐qPCR. Our RNA‐seq analysis revealed significant aberrant expression of 3054 lncRNAs and 1135 mRNAs compared to control samples. By applying weighted gene co‐expression network analysis (WGCNA), we identified 11 co‐expressed modules encompassing all genes. Notably, within the MEmagenta module, we observed an initial upregulation of differentially expressed genes (DEGs) at 4 h, followed by downregulation at 4‐ and 14‐days post‐UL. Our findings indicated that 3068 lncRNAs positively regulated 1259 DEGs, while 1482 lncRNAs negatively regulated 433 DEGs in the MVN. The RT‐qPCR results corroborated the RNA‐seq data, validating our findings. This study offers novel insights into the lncRNA‐mRNA expression landscape during vestibular compensation, paving the way for further exploration of lncRNA functions in this context.
Cover Image
Authors: Ko Young‐Chang , Lee Jungwon , Urban Istvan , Seol Yang‐Jo , Lee Yong‐Moo , Koo Ki‐Tae 
Published: July 2024

The cover image is based on the Original Article The adjunctive effect of polydeoxyribonucleotide on bone formation in alveolar ridge preservation: A pre‐clinical in vivo study by Young‐Chang Ko et al., https://doi.org/10.1111/jcpe.13988.image
Evaluation of the transition program at the University Hospital of Reims from 2015 to 2020
Authors: Chibane Sonia , Berot Aurélie , Lukas‐croisier Céline , Dollez Laure , Barraud Sara , Delemer Brigitte , Vitellius Géraldine 
Published: July 2024

ABSTRACTThe transition of young type 1 diabetic (T1D) patients from pediatric to adult healthcare is a high‐risk period of loss to follow‐up. Since 2015, we have implemented a transition program, involving both pediatric and adult clinicians. The main objective was to evaluate the number of patients who had succeeded this transition program at 1 year. We found that 86% of patients underwent the complete transition program. However, adverse outcomes occurred in 19.1% of patients at 1 year but decreased to 2.9% after 3 years. In 63% of patients their HbA1c level had deteriorated 1 year after the transition day and this level stabilized at around 8% in the following 2 and 3 years. In patients who had improved HbA1c levels the body mass index was lower (P = 0.03) and they lived alone (P = 0.04). Although our program seemed to allow a better follow‐up than previously described, this study highlights the importance of further supporting this transition period.
Parents who migrate without their children: Gendered and psychosocial reconfigurations of parenting in transnational families
Authors: Larrinaga‐Bidegain Nerea , Gemignani Marco , Hernández‐Albújar Yolanda 
Published: July 2024

AbstractWhat psychosocial impacts does migrating without children have on parents? How do the reconfigurations of gendered dynamics in transnational families (TFs) affect the well‐being and subjectivities of mothers and fathers in the hosting and sending communities? Through this literature meta‐synthesis, we describe six main areas of concern for parents who migrate without their children: (a) migration and family roles; (b) affects; (c) negotiations of gender, subjectivity, and family expectations; (d) family cohesion, tensions, and arrangements; (e) communication and the digital relational space; and (f) narratives on family reunification. We discuss the ways in which these areas and processes interact with each other within and around TFs. This article contributes to theories on family transnationality and transnational parenting by identifying and discussing specific dynamics of change and possibilities of becoming, which will be helpful to professionals working with TFs and to migrant parents to understand and anticipate likely family challenges.
SERKs serve as co‐receptors for SYR1 to trigger systemin‐mediated defense responses in tomato
Authors: Cho Hyewon , Seo Dain , Kim Minsoo , Nam Bo Eun , Ahn Soyoun , Kang Minju , Bang Geul , Kwon Choon‐Tak , Joo Youngsung , Oh Eunkyoo 
Published: July 2024

ABSTRACTSystemin, the first peptide hormone identified in plants, was initially isolated from tomato (Solanum lycopersicum) leaves. Systemin mediates local and systemic wound‐induced defense responses in plants, conferring resistance to necrotrophic fungi and herbivorous insects. Systemin is recognized by the leucine‐rich‐repeat receptor‐like kinase (LRR‐RLK) receptor SYSTEMIN RECEPTOR1 (SYR1), but how the systemin recognition signal is transduced to intracellular signaling pathways to trigger defense responses is poorly understood. Here, we demonstrate that SERK family LRR‐RLKs function as co‐receptors for SYR1 to mediate systemin signal transduction in tomato. By using chemical genetic approaches coupled with engineered receptors, we revealed that the association of the cytoplasmic kinase domains of SYR1 with SERKs leads to their mutual trans‐phosphorylation and the activation of SYR1, which in turn induces a wide range of defense responses. Systemin stimulates the association between SYR1 and all tomato SERKs (SlSERK1, SlSERK3A, and SlSERK3B). The resulting SYR1‐SlSERK heteromeric complexes trigger the phosphorylation of TOMATO PROTEIN KINASE 1B (TPK1b), a receptor‐like cytoplasmic kinase that positively regulates systemin responses. Additionally, upon association with SYR1, SlSERKs are cleaved by the Pseudomonas syringae effector HopB1, further supporting the finding that SlSERKs are activated by systemin‐bound SYR1. Finally, genetic analysis using Slserk mutants showed that SlSERKs are essential for systemin‐mediated defense responses. Collectively, these findings demonstrate that the systemin‐mediated association of SYR1 and SlSERKs activates defense responses against herbivorous insects.
Genome sequencing projects reveal new insights into the mammalian Gonadotropin‐releasing Hormone II system
Authors: Morgan Kevin , Millar Robert P. 
Published: July 2024

AbstractThe type II gonadotropin‐releasing hormone (GnRH‐II) was first discovered in chicken (Gallus gallus) brain and then shown to be present in many vertebrates. Indeed, its structure is conserved unchanged throughout vertebrate evolution from teleost fish through to mammals suggesting a crucial function. Yet the functional significance has been largely unexplored. Studies in comparative endocrinology show that the GnRH‐II system is differentially functional in mammalian species. Intact GnRH‐II neuropeptide and receptor genes (GnRH2 and GnRH receptor 2 GnRHR2) occur in marmoset monkeys (Callithrix jacchus), musk shrews (Suncus murinus) and pigs (Sus scrofa). However, one or other or both of these genes are inactivated in other species, where mutations or remnants affecting GnRH2 neuropeptide and/or type II GnRHR exons are retained in conserved genomic loci. New data from DNA sequencing projects facilitate extensive analysis of species‐specific variation in these genes. Here, we describe GnRH2 and GnRHR2 genes spanning a collection of 21 taxonomic orders, encompassing around 140 species from Primates, Scandentia, Eulipotyphla, Rodentia, Lagomorpha, Artiodactyla, Carnivora, Perissodactyls, Pholidota, Chiroptera, Afrotheria, Xenarthra and Marsupialia. Intact coding exons for both GnRH2 and GnRHR2 occur in monkeys, tree shrews, shrews, moles, hedgehogs, several rodents (degu, kangaroo‐rat, pocket mouse), pig, pecarry and warthog, camels and alpaca, bears, Weddell seal, hyena, elephant, aardvark and marsupials. Inactivating mutations affecting GnRH2 and GnRHR2, some located at conserved sites within exons, occur in species of primates, most rodents, lagomorphs, bovidae, cetaceans, felidae, canidae and other carnivora, pangolins, most bats, armadillo, brushtail and echidna. A functional GnRH‐II system appears retained within several taxonomic families of mammals, but intact retention does not extend to whole taxonomic orders. Defining how endogenous GnRH‐II neuropeptide operates in different mammals may afford functional insight into its actions in the brain, especially as, unlike the type I GnRH system, it is expressed in the mid brain and not the hypothalamus.
Effect of inhaled aromatherapy on sleep quality in critically ill patients: A systematic review and network meta‐analysis
Authors: Fang Chiu‐Shu , Tu Yu‐Kang , Chou Fan‐Hao , Fang Ching‐Ju , Chang Shih‐Lun 
Published: July 2024

AbstractAimThis study aimed to compare the effect of inhaled aromatherapy using various essential oils on the sleep quality of critically ill patients.BackgroundInhalation of essential oils significantly promotes the physiological and psychological health of patients in intensive care units (ICUs). However, research identifying and ranking the effects of different essential oils on the sleep quality of critically ill patients is lacking.DesignThis study followed the PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta‐Analyses of Health Care Interventions (PRISMA‐NMA) guidelines.MethodsA comprehensive search of five databases (Embase, MEDLINE, the Cochrane Library, CINAHL and PsycINFO) was conducted from their inception to March 15, 2023 (with an additional eligible study included dated August 14, 2023). Google Scholar was used as a supplementary method. Frequentist NMA was used to determine the effects of various essential oils. Certainty of evidence (CoE) was assessed using Confidence in Network Meta‐Analysis (CINeMA).ResultsA total of 11 trials involving 690 critically ill patients were included in the analysis. The NMA of inhaled aromatherapy revealed that the combination of lavender, Matricaria recutita, and neroli essential oils (ratio 6:2:0.5) resulted in the most significant improvement in sleep quality compared to usual care, followed by Rosa damascene, peppermint, Citrus aurantium, pure sunflower oil and lavender oil alone. The overall CoE for the results was rated as low.ConclusionsThe results of this study indicate that a combination of lavender, Matricaria recutita and neroli essential oils significantly positively affected sleep quality among critically ill patients. Despite the low quality of evidence, inhaled aromatherapy is non‐invasive and easy to use.Relevance to Clinical PracticeInhaled aromatherapy can effectively improve sleep quality among critically ill patients.Patient or Public ContributionNo patient or public contribution applies to this work.Study RegistrationThe study protocol was registered to the PROSPERO International Prospective Register of Systematic Reviews (protocol number CRD42023433194).
What comes next? A cross‐sectional study on post‐discharge referrals of adolescents treated in emergency services following a suicide attempt
Authors: Souza Danton Matheus de , Treichel Carlos Alberto dos Santos , Ribeiro Lucca Garcia Moreira , Boska Gabriella de Andrade , Rossato Lisabelle Mariano 
Published: July 2024

AbstractAimTo assess the proportions and associated factors of different post‐discharge referrals among adolescents treated in the emergency department after a suicide attempt.DesignObservational, cross‐sectional retrospective study.MethodsWe conducted a study using the medical records of 140 adolescents treated for a suicide attempt between January 2015 and May 2023 in a Brazilian emergency department, focusing on post‐discharge referrals, defined as discharge without referral, unaddressed referral and referral addressed to the network. Associations between the outcomes and other variables were analysed using a Poisson regression model.ResultsDischarges without referrals prevailed, followed by addressed and unaddressed referrals. Regression models showed associations between post‐discharge and age, prior continuous use of psychotropic medications, location of care, continued suicidal ideation at discharge and evaluation by a multi‐professional team.ConclusionA high number of adolescents were discharged from emergency departments without co‐ordination with the mental health network, and the involvement of the multi‐professional team was positively associated with addressed referrals.Implications for the Profession and/or Patient CareThis study informs healthcare professionals by raising awareness of their practices in discharging adolescents after suicide attempts in emergency departments, with the possibility of improving care quality and reducing the likelihood of readmission.Reporting MethodSTrengthening the Reporting of OBservational studies in Epidemiology (STROBE).Patient or Public ContributionNo patient or public contribution.
Risk factors associated with temporomandibular joint disorder: A mendelian randomization analysis
Authors: Yan Qinghan , Liao Lingzi , He Dengqi 
Published: July 2024

AbstractBackgroundTemporomandibular joint disorder (TMD), a prevalent orofacial disorder with complex aetiologies and considerable socioeconomic costs. This underscores the critical importance of developing a comprehensive understanding of the risk factors associated with TMD, as existing research is hindered by deficiencies in establishing causal relationships and the limitations of traditional research methodologies.ObjectivesThis research explores the causal link between certain risk factors and temporomandibular joint disorder (TMD) through Mendelian randomization (MR), providing multidimensional perspectives in addressing this worldwide health issue.MethodsUtilizing instrumental variables, we applied advanced statistical methods, including the weighted median, inverse variance weighted (IVW) and MR‐Egger, to evaluate the impact of twelve potential risk factors on TMD.ResultsOur results identified a significant positive association of TMD with malocclusion (p < .001), sleeping disorders (p = .006), anxiety (p = .002), major depression (p = .0002), daily cigarettes consumption (p = .029) and autoimmune diseases (p = .039). Conversely, a negative association was observed with educational attainment (p = .003).ConclusionThese findings suggest that malocclusion, sleeping disorders, anxiety, major depression, daily cigarettes consumption and autoimmune diseases, could potentially increase TMD risk while educational attainment might mitigate its increase. No direct causal relationships were established between serum 25‐hydroxyvitamin D levels, menopause, frequent alcohol consumption, coffee intake and severely worn dentition and TMD.
Politics and income taxes: Progress and progressivity
Authors: Berliant Marcus , Boyer Pierre C. 
Published: July 2024

AbstractThis paper begins with a survey of the literature on the political economy approaches to labor income taxation. We focus on recent progress made by examining in detail the specific properties of nonlinear taxes derived in the context of voting. Next, we present new results on the existence of a majority voting equilibrium that unifies work in the standard framework. Finally, we discuss how recent theoretical results help us uncover empirical patterns from the last 50 years in the US tax system, namely, a sharp decrease in top marginal tax rates, the rise of the Earned Income Tax Credit, and increased progressivity in the middle of the income distribution.
Feeding protocol for the Amazonian ornamental cichlid Apistogramma cacatuoides and a histological approach to the nutritional condition of larvae
Authors: Zanfurlin‐Lima Edmilson , Abe Higo Andrade , Gonçalves‐Junior Lucas Pedro , de Freitas Thiago Mendes 
Published: July 2024

AbstractThe aim of this study was to develop a feeding protocol for the larviculture of Apistogramma cacatuoides, using the histological approach to larval nutrition conditions. For this, three experiments were carried out. Experiment 1 was carried out in a randomized design to determine the optimal amount of Artemia nauplii (AN) per larva, and three treatments were evaluated: P1—feeding with 25 A. nauplii per larva (AN/L) during the first 5 days, followed by 50 AN/L from the 6th to the 10th day and 100 AN/L from the 11th to the 20th day; P2 and P3—37 and 50 AN/L during the first 5 days, 75 and 100 AN/L from the 6th to the 10th day and 150 and 200 AN/L from the 11th to the 20th day. Experiment 2 was carried out in a randomized design to determine the daily frequency of feeding and evaluated four feeding frequencies: F1—feeding only once a day (09:00); (F2)—feeding twice a day (09:00 and 17:00); F3—feeding three times a day (09:00, 11:30 and 17:00); and F4—feeding four times a day (09:00, 11: 30, 14:00 and 17:00). Experiment 3 lasted 40 days and was conducted in a randomized design to evaluate three periods for the beginning of the feeding transition: WE10:AN for 10 days, followed by 3 days of co‐feeding and commercial feed until the end of the experimental period; WE15:AN for 15 days, followed by 3 days of co‐feeding and commercial feed; WE20:AN for 20 days, followed by 3 days of co‐feeding and commercial feed. The results of this study showed that, for the best development of the larvae, they should receive the feeding protocol 50−100−200 AN/L (P3) until the 20th day of exogenous feeding. From the 21st day, the transition to inert food should begin with 3 days of co‐feeding, and feeding during larviculture should be carried out at a frequency of twice a day; this protocol provided a good nutritional status for the larvae, as shown by the histological approach.
Habitat loss and isolation threaten specialist flora in Baltic coastal meadows
Authors: Rimondini Lukas , Kimberley Adam , Cousins Sara A. O. 
Published: July 2024

AbstractQuestionsBaltic coastal meadows are ecologically unique habitats that have been severely impacted by habitat loss and environmental change. To determine the effects of habitat loss and isolation on their plant communities, we analysed the relationships between species richness and habitat size and amount. Because coastal meadows host species with a vast array of traits, we expected responses to vary between species groups.LocationSwedish Baltic coast.MethodsWe inventoried the presence of vascular plant species in twenty‐eight 1‐m2 plots placed along edaphically defined transects in fifteen coastal meadows. We determined the richness of three species groups: all species, halophytes and inland grassland specialists. We then mapped the habitat for coastal grassland plants using GIS overlay analysis. Using this habitat map, we calculated two variables: “habitat size” and “habitat amount”. We tested correlations between species richness measures and habitat variables, as well as determining the distribution of species traits within meadows.ResultsWe recorded 174 plant species, of which 6 were halophytes and 35 were inland grassland specialists. Species traits coincided with edaphic sea‐to‐land gradients. Halophyte and inland grassland specialist richness were significantly correlated with both habitat variables (r = 0.52–0.71). No correlations were found with total species richness. Our habitat map showed that there are 8,900 ha of managed Baltic coastal meadow left in Sweden, mostly in the south.ConclusionsSpecies traits and distribution play a major role in determining persistence in the face of habitat loss and environmental change. This is especially true for some halophyte populations, which are more susceptible to habitat size and isolation because of their specialisation. Furthermore, they risk being squeezed between the dual threats of encroaching succession and sea‐level rise. Preventing habitat loss, restoring meadows and increasing connectivity is crucial for the persistence of specialist plant species.
Philosophical research in Brazil: A structural topic modeling approach with a focus on temporal and gender trends
Authors: Fanton Marcos , Mota Hugo Ribeiro , de Melo Bomfim Araújo Carolina , da Silva Mitieli Seixas , Canuto Raquel 
Published: July 2024

AbstractThis paper employs structural topic modeling (STM) to describe the academic philosophy landscape in Brazil. Based on a public national database, a corpus consisting of 12,515 abstracts of monographs defended in philosophy graduate programs between 1991 and 2021 was compiled. The final STM model identified 74 meaningful research topics, clustered into 7 thematic categories. This study discusses the prevalence of the most significant topics and categories, their trends across three decades, and their (positive or negative) association with the supervisor's gender. Results show the first empirical evidence that Brazilian philosophical research exhibits a greater focus on philosophers than on specific themes or problems. Moreover, by visualizing the variations in topic prevalence over time, it was possible to track the rise or decline of the major interest categories and topics. Finally, results also show which topics are more influenced or less influenced by gender.
Baking bad: plants in a toasty world with necrotrophs
Authors: Suraj H. M. , van Kan Jan A. L. 
Published: July 2024

SummaryRising global temperatures pose a threat to plant immunity, making them more susceptible to diseases. The impact of temperature on plant immunity against biotrophic and hemi‐biotrophic pathogens is well documented, while its effect on necrotrophs remains poorly understood. We venture into the uncharted territory of necrotrophic fungal pathogens in the face of rising temperatures. We discuss the role of the plant hormones salicylic acid (SA) and jasmonic acid (JA) in providing resistance to necrotrophs and delve into the temperature sensitivity of the SA pathway. Additionally, we explore the repercussions of increased temperatures on plant susceptibility to necrotrophs. We put forward a research agenda with an experimental framework aimed at providing a comprehensive understanding of how plants and pathogens adapt to increasing temperatures.