bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet-Rich Plasma Attenuates 30-kDa Fibronectin Fragment–Induced Chemokine and Matrix Metalloproteinase Expression by Meniscocytes and Articular Chondrocytes
Authors: Wang Chih-Chien , Lee Chian-Her , Peng Yi-Jen , Salter Donald M. , Lee Herng-Sheng 
Published: August 2015

Background: Proteolytic fragments of fibronectin have catabolic effects on cartilage and menisci. Platelet-rich plasma (PRP) is increasingly being used to treat a range of joint conditions, but it is unknown whether PRP influences fibronectin fragment (FN-f) procatabolic activity. Hypotheses: The procatabolic activity of FN-f on meniscocytes and articular chondrocytes is attenuated by cotreatment with PRP. Study Design: Controlled laboratory study. Methods: Human meniscocytes were treated with FN-f (30 kDa) with or without PRP coincubation, and gene expression was analyzed by complementary DNA microarray analysis. Validation of altered expression of known and novel chemokine and protease genes was undertaken by real-time polymerase chain reaction (RT-PCR) in articular chondrocytes and meniscocytes. Chemokine release was assayed by enzyme-linked immunosorbent assay, and intracellular pathway signaling was evaluated by Western immunoblotting. Results: Microarray analysis and RT-PCR showed increased expression of matrix metalloproteinase ( MMP)1, MMP2, MMP3, MMP9, MMP13, interleukin ( IL)– 6, IL-8 ( CXCL8), CCL5, CCL20, and CXCL10 chemokines in meniscocytes after treatment with FN-f. Upregulation of these genes was significantly attenuated by PRP. Similar results were seen with articular chondrocytes, although no changes in MMP2 or MMP9 levels were identified. PRP-induced suppression of gene expression was associated with activation of Akt and p44/p42. Conclusion: PRP treatment attenuates the 30-kDa FN-f–induced expression of a range of proinflammatory chemokines and MMPs, including IL-8, IL-6, CCL20, CCL5, CXCL10, MMP1, MMP3, and MMP13, by both meniscocytes and articular chondrocytes. Clinical Relevance: These observations provide support for the use and further trials of PRP in management of cartilage and meniscal injuries.
The Ultimate Management: Unfinished Agenda of Management Education and Development
Authors: Prasad Rao DR. C.R. , Tammaiah DR. T. , Subba Raju MR. G.V. , Raju S.V.K.P.& DR. K.S. 
Published: August 2015

The central theme of this paper is self-managed development of Management Cadres. Self-managed is an exciting, revelational, and evolutional experience. Management being essentially normative, consciousness based management education and development is preferable to the intellect based one. The end result of consciousness-based subjective management is creativity which is essential in conditions of chaos and flux in the management field. Management development is better based on Indian mysticism to acquire the elements of subjectivity and creativity. The ultimate in management development is the Hindu mystical Yogic consciousness.
Managing Performance Through Excellence
Authors: Gill Satinder , Mehta Madhavi 
Published: August 2015

The present paper contends that it is the organization's focus on the critical aspects such as leadership, organizations culture, strategy, and HRD which results in excellent performance. The paper reemphasizes that leadership is considered to be the most influential factor contributing to the performance of excellent organizations whereas Organisation Culture, is the source of behavioural and functional patterns in an organization and determines the performance and productivity of the organization. Strategy outlines the organizations' goals and the means for attaining these goals. Whereas HRD plays a facilitating role in improving performance of an organization through Performance Appraisals, Training and Development, Feedback and Counselling and Career Planning and Development.
Marketing Strategy of Family Business in FMCG Sector
Authors: Shirur Srinivas 
Published: August 2015

Indian family business is moving through a transition phase. Before liberalisation, Industry was tightly controlled by the government and demand usually exceeding supply. In most of the sectors, there was suppliers market. Only resource which was scarce was finance. This will change after liberalisation. I have taken five companies which have developed core competency in FMCG Sector and compared their strategy with HLL. These companies are Dabur, Marico, Parry, Nirma & Godrej. Indian companies should shift their priority from finance and production to marketing in FMCG sector. Indian companies should try to launch a product in each segment, try to put their effort in managing the brands, improve their distribution network, try to compete head on with MNCs in premium brands, take advantage of information technology to keep track of the market and should follow contracting out strategy seriously in order to increase flexibility in the market.
Organizational Culture in Action
Authors: Kumar DR. Harish 
Published: August 2015

Organizational Culture represents one of the newest topics in the field of Organizational Behaviour. It refers to a set of key values, beliefs and understanding that are shared by the members of an organization. The focus of culture is to provide members with a sense of identity and to generate within them a commitment to the beliefs and values of the organization. If an organization understands its culture it can effectively respond to external problems of adaptation and survival and internal problems of integration.
Relationship between Size of the Organization and Quality of Worklife of Indian Managers
Authors: Karrir Naval , Khurana Amulya 
Published: August 2015

The study examines Quality of Worklife of 491 Managers with respect to size of organization (N: Large = 241, Medium = 132 and Small 118) from 30 organizations (Public =12, Private = 9, Cooperative = 9) of Indian Industry, using various univariate, bivariate and multivariate, statistical techniques. Results have revealed significant correlation between quality of worklife of Managers and size of organization. To arrive at specific results, superimposition of size of organization and sectoral differences have been done and results discussed. Key Words: Quality of Worklife feelings/Conditions (QWL F/C), Managers, Size of Organization (Small, Medium Large), Sectors (Public, Private, Cooperative)
E-Commerce and Globalisation
Authors: Bisht N S , Joshi Amit , Belwal Rakesh 
Published: August 2015

Simplistically put, E-Commerce means selling of products/services on the net a practice which has existed at least for the last two decades in the form of fax or phone. This is distinctly a post-Y2K focus. Merill Lynch proclaimed that on the IT front they would essentially cue in on E-Commerce for the economy of scales. Forrester research foresees the B2B potential hovering around US $ 842 Billion by 2002. The phenomenal growth of �Commerce has been due to the customer satisfaction. It has had its inimitable impact on the 4 Ps of marketing. �-Commerce in short has multidimensional potential. It is bound to have a telling effect on the pricing policies through the Webster listings. The futuristic growth of Ecommerce in India too is beyond doubt. The various aspects have to be harmonised and synchronised with the various situations. Sincere and careful analysis is required to encash the forthcoming opportunities.
Strategic Traps: A Case Based Analysis
Authors: Roy Dilip , Dutta Anindya 
Published: August 2015

Earlier functional approaches like marketing research, operation research management information system are now Jailing to yield successful strategic planning because of a continuous increase in the environmental entropy. This problem is engulfing the corporate world and there is a dire dearth for a remedial measure. While most of the thinkers are busy in search of an overall end solution, we have tried to define the starting problem and get into the roots of the same by critically examining many real life cases. And in the process of doing so, several strategic traps have been identified. We have grouped those strategic traps into seven different categories and illustrated them with a few typical examples.
Impact of Rosuvastatin in Contrast-Induced Acute Kidney Injury in the Elderly
Authors: Tropeano Francesco , Leoncini Mario , Toso Anna , Maioli Mauro , Dabizzi Laura , Biagini Debora , Villani Simona , Bellandi Francesco 
Published: August 2015

Background: Age is a major predictor of contrast-induced acute kidney injury (CI-AKI). Few studies have focused on CI-AKI in elderly patients with acute coronary syndrome (ACS). Methods: We compare the incidence of CI-AKI in patients <75 and ≥75 years enrolled in the Protective effect of Rosuvastatin and Antiplatelet Therapy On contrast-induced acute kidney injury and myocardial damage in patients with ACS (PRATO-ACS) study and explore the impact of high-dose rosuvastatin on CI-AKI and clinical outcomes in the 2 age-groups. Statin-naive patients with non-ST-segment elevation ACS scheduled for early invasive strategy (total 504) were randomized to rosuvastatin (40 mg on admission followed by 20 mg/day) or no statin treatment. Contrast-induced acute kidney injury was defined as creatinine increase ≥0.5 mg/dL or ≥25% above baseline within 72 hours after contrast administration. All patients were stratified in tertiles according to baseline high-sensitivity C-reactive protein (hs-CRP). Results: Rate of CI-AKI was significantly higher in patients ≥75 years (15.9% vs 8.7%, odds ratio: 2.001; 95% confidence interval: 1.14-3.53, P = .015). No significant interaction was observed between age and statin treatment ( P = .17). Pretreatment with rosuvastatin was associated with 65% relative reduction in CI-AKI rate (22/170 [12.9%] vs 8/177 [4.5%], P = .007) in younger patients and 38% (16/82 [19.5%] vs 9/75 [12%], P = .20) in the elderly individuals. The greatest protective effect of statin treatment was achieved in patients with the highest hs-CRP values in both age-groups. Conclusion: Patients ≥75 years with ACS had a higher risk of developing CI-AKI. Early high-dose rosuvastatin is efficacious in reducing kidney injury in all patients, especially those with the highest baseline hs-CRP values.
Epidemiology and statistics at the Nordic School of Public Health: Teaching and research 1979–2014
Authors: Eriksson Bo 
Published: August 2015

The Nordic School of Public Health (NHV) was jointly founded in 1953 by the Nordic countries. Until 1979, the school provided ad hoc courses on public health topics, using external teachers drawn mainly from the Nordic countries. At the time, the permanent staff of the school was small. In 1979, it began a Master’s degree programme and a few academic positions were established and filled, to support these courses. The programme included four main areas: Epidemiology, Social Medicine, Environmental Health and Health Services Administration. Epidemiology was compulsory in all Master of Public Health (MPH) exams, but there were a handful of optional courses that could be substituted for the other subjects. This paper tells the story of Epidemiology at NHV from about 1980, up until closure of the school in 2014. The original MPH model ran until 1995. Nursing Science entered NHV from about 1985 and worked mainly with qualitative research that often focused on individual patients. The new methods attracted nurses, midwives, psychologists and other groups that previously had been less represented in NHV. Being quantitative and population oriented, Epidemiology lost its unique position as a mandatory subject for the MPH examination. In addition the ‘New Public Health’ proposed by the World Health Organisation (WHO) that advocated health promotion and the philosophy of salutogenesis became a challenge for the programme in epidemiology: pathogenesis no longer was of primary interest. From 1995, the MPH format changed repeatedly and a DrPH programme was begun. For the last 8 years of its existence, NHV offered a reasonably comprehensive, basic course in Epidemiology. Throughout the years, epidemiology training and research at NHV were very traditional. In being a relatively free institution in terms of academic choices, NHV should have contributed to the development and innovation of epidemiology in public health. For several reasons, this did not happen.
Stenting as a bail-out option after failed percutaneous transluminal angioplasty in infrainguinal vein bypass grafts
Authors: Mathur K , Ayyappan MK , Hodson J , Hopkins J , Duddy MJ , Tiwari A , Vohra RK 
Published: August 2015

Objectives To study the safety and efficacy of bare and covered stents in infrainguinal vein grafts after failure of PTA for treating graft stenoses. Methods An analysis of a prospective database of all patients who underwent stenting of infrainguinal vein bypass grafts at this institution between 1 January 2008 and 31 December 2012 was carried out. The main outcome considered was primary patency, which was reported at 1, 6 and 12 months. Results A total of 18 patients with a mean age of 73 years (range: 56 to 86) were included. The indications for stent placement were significant recoil (7, 39%), graft rupture (6, 33%), residual vein cusps (3, 17%) and aneurysmal degeneration (2, 11%). There was a high overall technical success rate of 94% (17/18) and arrest of haemorrhage was achieved in all cases of graft rupture. The primary patency at 1, 6 and 12 months was 89%, 71% and 59%, respectively. Conclusion The use of bare and covered stents in infrainguinal vein grafts appears safe and effective. They are an excellent bail-out option for the treatment of graft rupture and give acceptable short-term results.
Validity of the Disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and the Quickdash when used in Dupuytren’s disease
Authors: Rodrigues J. , Zhang W. , Scammell B. , Russell P. , Chakrabarti I. , Fullilove S. , Davidson D. , Davis T. 
Published: August 2015

This study investigated aspects of the validity and reliability of the 30-item Disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and its relationship with the shorter 11-item QuickDASH in patients with Dupuytren’s disease. Seven hundred and fifty-nine DASH questionnaires were studied, covering pre- and postoperative patients undergoing different treatments for Dupuytren’s disease. Items related to pain rose early after treatment before returning to baseline, suggesting that studying pain is relevant during postoperative recovery. Across all 759 sets of responses, the QuickDASH agreed closely with the DASH. In exploratory factor analysis, the DASH was not unidimensional, questioning the validity of the DASH summary score in Dupuytren’s disease. Further validation of existing PROMs for use in Dupuytren’s disease is needed. These data suggest that pain is a relevant symptom to study during postoperative recovery following treatment for Dupuytren’s disease. Level of evidence: III.
Foreign Body Reaction to Implantable Biosensors
Authors: Wang Yan , Vaddiraju Santhisagar , Gu Bing , Papadimitrakopoulos Fotios , Burgess Diane J. 
Published: August 2015

Background: Implantable biosensors for continuous glucose monitoring can greatly improve diabetes management. However, their applications are still associated with some challenges and one of these is the gradual functionality loss postimplantation as a consequence of the foreign body response (FBR). Sensor miniaturization in combination with drug-eluting biocompatible coatings is a promising strategy to enhance in vivo performance. However, limited study has been performed to understand the effect of initial trauma and implant size on foreign body reaction as well as in vivo performance of implantable glucose sensors. Methods: Different initial trauma was induced by implanting composite coated dummy sensors into rats using various sized needles and 3 different-sized dummy sensors were implanted to examine the size effect. Histological evaluation was performed to relate the inflammatory cell counts and foreign body capsule thickness with the implantation needle size and sensor size respectively. The effect of biocompatible coating on the performance of implantable glucose sensors was determined using both coated amperometric glucose sensors and microdialysis probes. Results: The results revealed that the degree of acute inflammation was mainly controlled by the extent of the initial trauma: the greater the trauma, the greater the acute inflammatory response. Implant size did not affect the acute inflammatory phase. However, the extent of chronic inflammation and fibrous encapsulation were affected by sensor size: the smaller the size the less the extent of chronic inflammation and fibrous encapsulation. Glucose sensors implanted using 14 gauge needles showed significantly lower initial in vivo response compared to those implanted using 16 gauge needles. This was not observed for sensors with dexamethasone-eluting biocompatible coatings since inflammation was suppressed. Conclusions: The results of the current study indicate that the extent of the inflammatory response post–sensor implantation varies as a function of the initial tissue trauma as well as the sensor size. Accordingly, miniaturization of implantable biosensors together with the utilization of a drug-eluting biocompatible composite coating may be a promising strategy to achieve long-term reliable continuous glucose monitoring.
The accuracy of clinical symptoms in detecting cauda equina syndrome in patients undergoing acute MRI of the spine
Authors: Ahad Abdul , Elsayed Mohammed , Tohid Hassaan 
Published: August 2015

A large number of patients do not have cauda equina syndrome (CES) on MRI to account for their clinical findings; consequently, the majority of urgent scans requested are normal. We aimed to determine whether any clinical manifestation of CES, as stated in Royal College of Radiology guidelines, could predict the presence of established CES on MRI. We also aimed to support a larger study to develop a more universal assessment tool for acute lower back pain. A retrospective analysis of consecutive patients who warranted urgent MRI was conducted. Seventy-nine patients were eligible for study. The Kendall’s tau test was used for statistical analysis of all data. A p value of less than 0.05 was considered to be significant. MRI was performed in 62 patients out of 79. A total of 32.9% of patients had scans within 24 hours of admission. Nine of these patients were referred to neurosurgery for urgent neurosurgical review. Of these, 6.3% of patients had an established CES on MRI scan. One patient who had an out-patient MRI spine (15 days from hospital presentation) was found to have an established CES, was urgently referred to spinal surgery and underwent primary fenestration excision of the lumbar vertebra. No clinical features that were able to predict the presence of an established CES on MRI were elucidated. Findings included decreased anal tone 7.6% ( p = 0.282), faecal incontinence 3.8% ( p = 0.648), urinary retention 7.6% ( p = 0.510), bladder incontinence 8.9% ( p = 0.474), constipation 2.5% ( p = 0.011) and saddle anaesthesia 8.9% ( p = 0.368). Patients who had an abnormal MRI spine for back pain prior to this presentation showed a correlation with a newly diagnosed CES on MRI ( p = 0.016) with a correlation coefficient of 0.272.
Management of Sleep Quality and Pain in an Individual Living with HIV and Hepatitis C Coinfection Using an Activity Monitor
Authors: Sandoval Roberto , Gilkerson Rachel 
Published: August 2015

Study Design: Case report. Background: Twenty-five percent of people living with HIV/AIDS (PLWHA) are also coinfected with hepatitis C virus (HCV). There are limited reports to assist in the symptom management of PLWHA and HCV coinfection. Case Description: Our case was a 67-year-old man living with HIV/HCV coinfection and other medical complications. Our intervention consisted of a 6-week progressive conditioning program, while his activity and sleep pattern were monitored using a wrist accelerometer. Outcomes: After completing a conditioning training, there was a 64% decrease in the number of waking episodes per night and 68% decrease in activity at night. Based on Pittsburgh Sleep Quality Index scores, the participant transitioned from being a “poor sleeper” to a “good sleeper.” A 40% decrease in pain was reported. Functional outcome measures also showed improvements. Discussion: There were improvements in the participant’s sleep quality and pain. The use of a commercial accelerometer may assist in objectively tracking compliance and activity changes.
Features of Metabolic Syndrome and Its Associated Factors during Highly Active Antiretroviral Therapy in Ouagadougou (Burkina Faso)
Authors: Guira Oumar , Tiéno Hervé , Diendéré Arnaud Eric , Sagna Yempabou , Diallo Ismael , Yaméogo Bertille , Zoungrana Lassané , Yaméogo Tènè Marceline , Bognounou Réné , Drabo Joseph Youssouf 
Published: August 2015

Background: To study the features of metabolic syndrome (MS) and its associated factors during highly active antiretroviral therapy (HAART), in Ouagadougou. Methods: It was a cross-sectional study from March to November 2011 in Yalgado Ouédraogo hospital. A nonprobability sample of adults receiving antiretroviral drugs for at least 6 months was studied. Pregnancy, ascites, or abdominal mass were noninclusion criteria. Metabolic syndrome met the criteria of International Diabetes Federation 2005. Results: The authors studied 300 patients. Metabolic syndrome was diagnosed in 54 (18%) patients: mean age 44.8 ± 7.4 years, sex ratio 0.17, and mean duration of HAART 71 ± 30.9 months. The current anomaly of MS was low high-density lipoprotein (HDL)-cholesterol in 37 patients (68.5%), and the common profile of MS was high waist circumference + low HDL-cholesterol + abnormal blood pressure (29.6%). Associated factors were protease inhibitor regimens ( P = .000), female gender ( P = .004), age > 42 years ( P = .001), and lipodystrophy ( P = .01). Conclusion: Cardiovascular risks should be regarded during the care of HIV-infected patients.