bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between diabetes mellitus and subsequent non-communicable diseases in Indonesia
Authors: Pratiwi Jasmine A. Dwi , Huang Chun-Ta , Juber Nirmin F. , Liu Jason J. 
Published: June 2024

Abstract
Objective
To understand how diabetes mellitus (DM) diagnosed at different ages of adulthood are associated with various incident subsequent non-communicable diseases (NCDs).

Methods
We performed a nationwide population-based analysis comparing 212 participants first diagnosed with DM at 20–39, 40–49, 50–59, or 60–69 years of age, with 17,541 participants without DM history, using data from the Indonesian Family Life Survey. Subsequent NCDs that were examined included hypertension, lung diseases, heart diseases, arthritis, liver diseases, kidney diseases, and digestive diseases. We estimated weighted risk ratios and 95% confidence intervals using Poisson regression, adjusting for age, sex, urbanicity, and tobacco use history.

Results
Those diagnosed with DM in all age groups had significantly higher risk of hypertension, compared with those without DM history. Compared with those without DM history, younger individuals with DM diagnosed at 20–39 years of age had significantly higher risks of lung diseases and arthritis, and those with DM diagnosed at 20–49 years of age had significantly higher risk of digestive diseases. Older individuals with DM diagnosed at 40–69 years of age had significantly higher risk of liver diseases, and those with DM diagnosed at 40–59 years of age had significantly higher risk of heart diseases, compared with those without DM history. Participants with DM were diagnosed with subsequent NCDs at younger ages compared with those without DM history.

Conclusion
Our findings contribute to health surveillance and may promote beneficial lifestyle changes in those with early-onset and later-onset DM, which can help prevent subsequent NCDs and improve public health.
Fuzzy Decision Support Systems to Improve the Effectiveness of Training Programs in the Field of Sports Fitness
Authors: An Peng 
Published: June 2024

AbstractTo maximize training programs and improve individual performance, the sports fitness profession is always looking for new and innovative solutions. Fuzzy decision support systems provide a strong basis for improving training regimen efficacy through flexible and adaptive decision-making. In sports fitness, doing things differently might affect the way one can train and even lead to injury. Particularly if exercises call for expert training regimens, determining if fitness requirements are sufficiently satisfied is a difficult task. Athletes participate in training programs focusing on strengthening their bodies and minds to perform better. Each sport has unique needs, and athletes should prepare to meet those demands while still meeting their sport’s general fitness activity requirements. A novel strategy for assisting athletes with fitness-related decision-making is presented in this study as the Fitness Mamdani Decision System. At the outset, the system provides an adaptive decision framework to improve the effectiveness of training programs by applying the principles of intuitionistic fuzzy numbers and fuzzy logic. The study wants to know how to train effectively, and it takes important factors like your mood, degree of preparation, sleep quality, and stress levels into account. Using language-specific terminology and triangle membership functions, the Mamdani fuzzy inference system generates rules based on analyzing these crucial elements. Regarding measures like adaptability index, training load capacity, long-term program efficiency, and participation ratio among sports fitness individuals, the system is guided by fuzzy rules that infer decisions.
The role of language in transcending core knowledge
Authors: Carey Susan 
Published: June 2024

Abstract
What Babies Know (WBK) argues that core knowledge has a unique place in cognitive architecture, between fully perceptual and fully conceptual systems of representation. Here I argue that WBK's core knowledge is on the perception side of the perception/cognition divide. I discuss some implications of this conclusion for the roles language learning might play in transcending core knowledge.
Core knowledge and its role in explaining uniquely human cognition: Some questions
Authors: Schulz Armin W. 
Published: June 2024

Abstract
Questions can be raised about the central status that evolutionarily ancient core knowledge systems are given in Spelke's otherwise very compelling theory. So, the existence of domain-general learning capacities has to be admitted, too, and no clear reason is provided to doubt the existence of uniquely human cognitive adaptations. All of these factors should be acknowledged when explaining human thought.
Response to commentaries on What Babies Know
Authors: Spelke Elizabeth S. 
Published: June 2024

Abstract
Twenty-five commentaries raise questions concerning the origins of knowledge, the interplay of iconic and propositional representations in mental life, the architecture of numerical and social cognition, the sources of uniquely human cognitive capacities, and the borders among core knowledge, perception, and thought. They also propose new methods, drawn from the vibrant, interdisciplinary cognitive sciences, for addressing these questions and deepening understanding of infant minds.
Developmental cascades from early childhood attachment security to adolescent level of personality functioning among high-risk youth
Authors: O’Gorman Emily T. , Meyer Gregory J. 
Published: June 2024

Abstract
This study examines associations between early childhood attachment security and adolescent personality functioning in a high-risk sample within a developmental psychopathology framework. Data from 2,268 children (1165 male; 1103 female) and caregivers participating in Future of Families and Child Well-Being Study (FFCWS) were used to examine (1) effects of genetic polymorphisms of the serotonin transporter (5-HTTLPR) and dopamine D4 receptor (DRD4) genes and adverse childhood experiences (ACEs) on attachment security and emotional and behavioral dysregulation in early childhood and (2) longitudinal associations and transactional relationships among attachment security, dysregulation, negative parenting attitudes and behaviors, social competence, and adolescent personality functioning. Results revealed that ACEs predicted attachment security over and above sex or the genetic risk, and gene × environment interactions did not increment prediction. Results of cascade models showed that greater early childhood attachment security predicted higher adolescent level of personality functioning via pathways through intermediary variables. Limitations and future research directions are discussed.
Model‐Based Investigation of Electron Precipitation‐Driven Density Structures and Their Effects on Auroral Scintillation
Authors: Vaggu Pralay Raj , Zettergren Matt , Deshpande Kshitija , Nishimura Yukitoshi , Semeter Joshua , Hirsch Michael , Hampton Don , Lamarche Leslie , Datta‐Barua Seebany 
Published: June 2024

AbstractElectron density irregularities in the ionosphere can give rise to scintillations, affecting radio wave phase and amplitude. While scintillations in the cusp and polar cap regions are commonly associated with mesoscale density inhomogeneities and/or shearing, the auroral regions exhibit a strong correlation between scintillation and density structures generated by electron precipitation (arcs). We aim to examine the impact of electron precipitation on the formation of scintillation‐producing density structures using a high‐resolution physics‐based plasma model, the “Geospace Environment Model of Ion‐Neutral Interactions,” coupled with a radio propagation model, the “Satellite‐beacon Ionospheric‐scintillation Global Model of the upper Atmosphere.” Specifically, we explore the effects of varying spatial and temporal characteristics of the precipitation, including electron total energy flux and their characteristic energies, obtained from the all‐sky‐imagers and Poker Flat Incoherent Scatter Radar observations, on auroral scintillation. To capture small‐scale structures, we incorporate a power‐law turbulence spectrum that induces short wavelength features sensitive to scintillation. Finally, we compare our simulated scintillation results with satellite‐observed scintillations, along with spectral comparisons.
Why do adolescents attempt suicide? Insights from leading ideation-to-action suicide theories: a systematic review
Authors: Kirshenbaum Jaclyn S. , Pagliaccio David , Bitran Alma , Xu Elisa , Auerbach Randy P. 
Published: June 2024

AbstractSuicide is a leading cause of death among adolescents, and recent suicide theories have sought to clarify the factors that facilitate the transition from suicide ideation to action. Specifically, the Interpersonal Theory of Suicide (IPTS), Integrated Motivational-Volitional Model (IMV), and Three Step Theory (3ST) have highlighted risk factors central to the formation of suicidal ideation and suicidal behaviors, which is necessary for suicide death. However, these models were initially developed and tested among adults, and given core socioemotional and neurodevelopmental differences in adolescents, the applicability of these models remains unclear. Directly addressing this gap in knowledge, this systematic review aimed to (1) describe the evidence of leading ideation-to-action theories (i.e., IPTS, IMV, 3ST) as they relate to suicide risk among adolescents, (2) integrate ideation-to-action theories within prevailing biological frameworks of adolescent suicide, and (3) provide recommendations for future adolescent suicide research. Overall, few studies provided a complete test of models in adolescent samples, and empirical research testing components of these theories provided mixed support. Future research would benefit from integrating neurodevelopmental and developmentally sensitive psychosocial frameworks to increase the applicability of ideation-to-action theories to adolescents. Further, utilizing real-time monitoring approaches may serve to further clarify the temporal association among risk factors and suicide.
Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence
Authors: Joruiz Sebastien M. , Von Muhlinen Natalia , Horikawa Izumi , Gilbert Mark R. , Harris Curtis C. 
Published: June 2024

AbstractDespite being mutated in 92% of TP53 mutant cancers, how mutations on p53 isoforms affect their activities remain largely unknown. Therefore, exploring the effect of mutations on p53 isoforms activities is a critical, albeit unexplored area in the p53 field. In this article, we report for the first time a mutant Δ133p53α-specific pathway which increases IL4I1 and IDO1 expression and activates AHR, a tumor-promoting mechanism. Accordingly, while WT Δ133p53α reduces apoptosis to promote DNA repair, mutant R273H also reduces apoptosis but fails to maintain genomic stability, increasing the risks of accumulation of mutations and tumor’s deriving towards a more aggressive phenotype. Furthermore, using 2D and 3D spheroids culture, we show that WT Δ133p53α reduces cell proliferation, EMT, and invasion, while the mutant Δ133p53α R273H enhances all three processes, confirming its oncogenic potential and strongly suggesting a similar in vivo activity. Importantly, the effects on cell growth and invasion are independent of mutant full-length p53α, indicating that these activities are actively carried by mutant Δ133p53α R273H. Furthermore, both WT and mutant Δ133p53α reduce cellular senescence in a senescence inducer-dependent manner (temozolomide or radiation) because they regulate different senescence-associated target genes. Hence, WT Δ133p53α rescues temozolomide-induced but not radiation-induced senescence, while mutant Δ133p53α R273H rescues radiation-induced but not temozolomide-induced senescence. Lastly, we determined that IL4I1, IDO1, and AHR are significantly higher in GBMs compared to low-grade gliomas. Importantly, high expression of all three genes in LGG and IL4I1 in GBM is significantly associated with poorer patients’ survival, confirming the clinical relevance of this pathway in glioblastomas. These data show that, compared to WT Δ133p53α, R273H mutation reorientates its activities toward carcinogenesis and activates the oncogenic IL4I1/IDO1/AHR pathway, a potential prognostic marker and therapeutic target in GBM by combining drugs specifically modulating Δ133p53α expression and IDO1/Il4I1/AHR inhibitors.
MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma
Authors: Olarewaju Olaniyi , Hu Yuhai , Tsay Hsin-Chieh , Yuan Qinggong , Eimterbäumer Simon , Xie Yu , Qin Renyi , Ott Michael , Sharma Amar Deep , Balakrishnan Asha 
Published: June 2024

AbstractHepatocellular carcinoma is a primary liver cancer, characterised by diverse etiology, late diagnoses, and poor prognosis. Hepatocellular carcinoma is mostly resistant to current treatment options, therefore, identification of more effective druggable therapeutic targets is needed. We found microRNA miR-20a-5p is upregulated during mouse liver tumor progression and in human hepatocellular carcinoma patients. In this study, we elucidated the therapeutic potential of targeting oncogenic miR-20a-5p, in vivo, in a xenograft model and in two transgenic hepatocellular carcinoma mouse models via adeno-associated virus-mediated miR-20a-Tough-Decoy treatment. In vivo knockdown of miR-20a-5p attenuates tumor burden and prolongs survival in the two independent hepatocellular carcinoma mouse models. We identified and validated cytochrome c as a novel target of miR-20a-5p. Cytochrome c plays a key role in initiation of the apoptotic cascade and in the electron transport chain. We show for the first time, that miR-20a modulation affects both these key functions of cytochrome c during HCC development. Our study thus demonstrates the promising ‘two birds with one stone’ approach of therapeutic in vivo targeting of an oncogenic miRNA, whereby more than one key deregulated cellular process is affected, and unequivocally leads to more effective attenuation of HCC progression and significantly longer overall survival.
The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects
Authors: Wu Yalan , Liu Huixia , Sun Zhe , Liu Jieling , Li Kai , Fan Ronghui , Dai Fujun , Tang Hui , Hou Qi , Li JinSong , Tang Xiaolong 
Published: June 2024

AbstractADGRF5 (GPR116) has been identified as a facilitator of breast cancer cell migration and metastasis, yet the underlying mechanisms remain largely elusive. Our current study reveals that the absence of ADGRF5 in breast cancer cells impairs extracellular matrix (ECM)-associated cell motility and impedes in vivo tumor growth. This correlates with heightened expression of matrix metalloproteinase 8 (MMP8), a well-characterized antitumorigenic MMP, and a shift in the polarization of tumor-associated neutrophils (TANs) towards the antitumor N1 phenotype in the tumor microenvironment (TME). Mechanistically, ADGRF5 inhibits ERK1/2 activity by enhancing RhoA activation, leading to decreased phosphorylation of C/EBPβ at Thr235, hindering its nuclear translocation and subsequent activation. Crucially, two C/EBPβ binding motifs essential for MMP8 transcription are identified within its promoter region. Consequently, ADGRF5 silencing fosters MMP8 expression and CXCL8 secretion, attracting increased infiltration of TANs; simultaneously, MMP8 plays a role in decorin cleavage, which leads to trapped-inactivation of TGF-β in the TME, thereby polarizing TANs towards the antitumor N1 neutrophil phenotype and mitigating TGF-β-enhanced cell motility in breast cancer. Our findings reveal a novel connection between ADGRF5, an adhesion G protein-coupled receptor, and the orchestration of the TME, which dictates malignancy progression. Overall, the data underscore ADGRF5 as a promising therapeutic target for breast cancer intervention.
Efficient removal of nanoplastics from industrial wastewater through synergetic electrophoretic deposition and particle-stabilized foam formation
Authors: Abdeljaoued Amna , Ruiz Beatriz López , Tecle Yikalo-Eyob , Langner Marie , Bonakdar Natalie , Bleyer Gudrun , Stenner Patrik , Vogel Nicolas 
Published: June 2024

AbstractMicroplastic particles have been discovered in virtually all ecosystems worldwide, yet they may only represent the surface of a much larger issue. Nanoplastics, with dimensions well below 1 µm, pose an even greater environmental concern. Due to their size, they can infiltrate and disrupt individual cells within organisms, potentially exacerbating ecological impacts. Moreover, their minute dimensions present several hurdles for removal, setting them apart from microplastics. Here, we describe a process to remove colloidally stable nanoplastics from wastewater, which synergistically combines electrophoretic deposition and the formation of particle-stabilized foam. This approach capitalizes on localized changes in particle hydrophilicity induced by pH fluctuations resulting from water electrolysis at the electrode surface. By leveraging these pH shifts to enhance particle attachment to nascent bubbles proximal to the electrode, separation of colloidal particles from aqueous dispersions is achieved. Using poly(methyl methacrylate) (PMMA) colloidal particles as a model, we gain insights into the separation mechanisms, which are subsequently applied to alternative model systems with varying surface properties and materials, as well as to real-world industrial wastewaters from dispersion paints and PMMA fabrication processes. Our investigations demonstrate removal efficiencies surpassing 90%.
Distributable, metabolic PET reporting of tuberculosis
Authors: Khan R. M. Naseer , Ahn Yong-Mo , Marriner Gwendolyn A. , Via Laura E. , D’Hooge Francois , Seo Lee Seung , Yang Nan , Basuli Falguni , White Alexander G. , Tomko Jaime A. , Frye L. James , Scanga Charles A. , Weiner Danielle M. , Sutphen Michelle L. , Schimel Daniel M. , Dayao Emmanuel , Piazza Michaela K. , Gomez Felipe , Dieckmann William , Herscovitch Peter , Mason N. Scott , Swenson Rolf , Kiesewetter Dale O. , Backus Keriann M. , Geng Yiqun , Raj Ritu , Anthony Daniel C. , Flynn JoAnne L. , Barry Clifton E. , Davis Benjamin G. 
Published: June 2024

AbstractTuberculosis remains a large global disease burden for which treatment regimens are protracted and monitoring of disease activity difficult. Existing detection methods rely almost exclusively on bacterial culture from sputum which limits sampling to organisms on the pulmonary surface. Advances in monitoring tuberculous lesions have utilized the common glucoside [18F]FDG, yet lack specificity to the causative pathogen Mycobacterium tuberculosis (Mtb) and so do not directly correlate with pathogen viability. Here we show that a close mimic that is also positron-emitting of the non-mammalian Mtb disaccharide trehalose – 2-[18F]fluoro-2-deoxytrehalose ([18F]FDT) – is a mechanism-based reporter of Mycobacteria-selective enzyme activity in vivo. Use of [18F]FDT in the imaging of Mtb in diverse models of disease, including non-human primates, successfully co-opts Mtb-mediated processing of trehalose to allow the specific imaging of TB-associated lesions and to monitor the effects of treatment. A pyrogen-free, direct enzyme-catalyzed process for its radiochemical synthesis allows the ready production of [18F]FDT from the most globally-abundant organic 18F-containing molecule, [18F]FDG. The full, pre-clinical validation of both production method and [18F]FDT now creates a new, bacterium-selective candidate for clinical evaluation. We anticipate that this distributable technology to generate clinical-grade [18F]FDT directly from the widely-available clinical reagent [18F]FDG, without need for either custom-made radioisotope generation or specialist chemical methods and/or facilities, could now usher in global, democratized access to a TB-specific PET tracer.
Hydrogen bond symmetrisation in D2O ice observed by neutron diffraction
Authors: Komatsu Kazuki , Hattori Takanori , Klotz Stefan , Machida Shinichi , Yamashita Keishiro , Ito Hayate , Kobayashi Hiroki , Irifune Tetsuo , Shinmei Toru , Sano-Furukawa Asami , Kagi Hiroyuki 
Published: June 2024

AbstractHydrogen bond symmetrisation is the phenomenon where a hydrogen atom is located at the centre of a hydrogen bond. Theoretical studies predict that hydrogen bonds in ice VII eventually undergo symmetrisation upon increasing pressure, involving nuclear quantum effect with significant isotope effect and drastic changes in the elastic properties through several intermediate states with varying hydrogen distribution. Despite numerous experimental studies conducted, the location of hydrogen and hence the transition pressures reported up to date remain inconsistent. Here we report the atomic distribution of deuterium in D2O ice using neutron diffraction above 100 GPa and observe the transition from a bimodal to a unimodal distribution of deuterium at around 80 GPa. At the transition pressure, a significant narrowing of the peak widths of 110 is also observed, attributed to the structural relaxation by the change of elastic properties.
Expression of tumor antigens within an oncolytic virus enhances the anti-tumor T cell response
Authors: Webb Mason J. , Sangsuwannukul Thanich , van Vloten Jacob , Evgin Laura , Kendall Benjamin , Tonne Jason , Thompson Jill , Metko Muriel , Moore Madelyn , Chiriboga Yerovi Maria P. , Olin Michael , Borgatti Antonella , McNiven Mark , Monga Satdarshan P. S. , Borad Mitesh J. , Melcher Alan , Roberts Lewis R. , Vile Richard 
Published: June 2024

AbstractAlthough patients benefit from immune checkpoint inhibition (ICI) therapy in a broad variety of tumors, resistance may arise from immune suppressive tumor microenvironments (TME), which is particularly true of hepatocellular carcinoma (HCC). Since oncolytic viruses (OV) can generate a highly immune-infiltrated, inflammatory TME, OVs could potentially restore ICI responsiveness via recruitment, priming, and activation of anti-tumor T cells. Here we find that on the contrary, an oncolytic vesicular stomatitis virus, expressing interferon-ß (VSV-IFNß), antagonizes the effect of anti-PD-L1 therapy in a partially anti-PD-L1-responsive model of HCC. Cytometry by Time of Flight shows that VSV-IFNß expands dominant anti-viral effector CD8 T cells with concomitant relative disappearance of anti-tumor T cell populations, which are the target of anti-PD-L1. However, by expressing a range of HCC tumor antigens within VSV, combination OV and anti-PD-L1 therapeutic benefit could be restored. Our data provide a cautionary message for the use of highly immunogenic viruses as tumor-specific immune-therapeutics by showing that dominant anti-viral T cell responses can inhibit sub-dominant anti-tumor T cell responses. However, through encoding tumor antigens within the virus, oncolytic virotherapy can generate anti-tumor T cell populations upon which immune checkpoint blockade can effectively work.