bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoliberalismo, economía keynesiana y la respuesta a la inflación actual
Authors: Stiglitz Joseph E. 
Published: July 2024

El artículo hace una crítica a las políticas neoliberales que usualmente se aplican para solucionar las distintas crisis y problemas económicos de las últimas décadas. Argumenta que tales acciones no se basan en la realidad económica, por lo que no son efectivas ni se enfocan en las formas en que afectan negativamente a distintos grupos sociales —como desempleo, aumento de desigualdad, crisis de vivienda—, pues sólo se conciben como daños colaterales. Aterriza esta reflexión en las políticas económicas aplicadas a dos fenómenos actuales: la crisis por la pandemia de covid-19 y la inflación, que han dejado en evidencia la necesidad de una intervención más activa del gobierno.
Monitoring vegetation cover trends in the steppe region of western Algeria using MODIS imagery
Authors: Kious Chahrazed , Maatoug M’hamed , Bouacha Mohamed Islam , Maatoug Zakaria Zineddine 
Published: July 2024

The steppe region of Chehaima (Tiaret Province, northwestern Algeria) covers an area of 2,202 km², representing 10.94% of the total area of Tiaret. This study identified the ecological state of the area using a spatial theme from a 24-year synchronized moderate-resolution imaging spectroradiometer (MODIS) satellite image campaign (2000–2023). The adopted method consists of analyzing spectral indices (normalized difference vegetative index, low surface temperature (LST), and soil moisture index) from MODIS sensors (MOD13Q1), making it possible to evaluate the spatiotemporal dynamics of the vegetation in the study area and to identify regions degraded by several biotic and abiotic factors. The results show a vegetation cover rate of intense fluctuations in unfavorable conditions over 24 years. The percentage of plant growth recorded does not exceed 32%. The abundance of LST vegetation decreases when the LST exceeds 35°C, with a soil that has a water deficit. The De Martonne aridity index (<em>I</em>) classifies the study area as a lower semiarid bioclimatic zone. These indicators made it possible to determine the spatiotemporal dynamics of vegetation, which modifies the plant cover, leading to the loss of native species such as alfa <em>Stipa tenacissima</em> L. Defensive measures are necessary over large areas of the study area to allow successful protection of steppe rangelands through a sustainable conservation strategy, preserving endemic species, stabilizing dunes, and adopting the steppe rotation system.
The Business Value of an Employee Assistance Programme in the Oil Industry in Trinidad and Tobago - A Ten Year Stakeholder Review (1988 - 1999)
Authors: Remy L. F. 
Published: July 2024

Abstract
Petrotrin is an integrated national oil company in the republic of Trinidad and Tobago, located in the southernmost tip of the Caribbean Archipelago seven miles east of Venezuela. Petrotrin is the result of a merger of two former state owned companies Trintoc and Trintopec which was consummated in 1993. The current employee population is four thousand (4000).
An Employee Assistance Program (EAP) was established in 1988. The EAP was intended as a support system designed to prevent and reduce human factor problems associated with performance deficiencies at the individual as well as the organisational levels. The EAP became fully integrated fully integrated with the HSE function and this led to certain measurable outcomes with the operating business units. This paper will present the results of a Stakeholder evaluation of the impact and value to the Board of Management. the Executive council. The Strategic Business Units, the worker representatives as well as employees. The use of Video vignettes will be included to provide examples of selected stake holder feedback within the context of the presentation. The paper will also present utilisation data and an evaluation of the effectiveness of strategies implemented during the ten year period.
Mapping Mitochondrial Channel Toxicity: A Case Study for Predicting Mito-Target Interactions for the Per- and Poly-Fluoroalkyl Compounds on the Zebrafish Voltage-Dependent Anion Channel 2
Authors: González-Durruthy Michael , Halder Amit Kumar , Moura Ana Silveira , Cordeiro Maria Natália Dias Soeiro 
Published: July 2024

Abstract

The significance of effective and reliable prediction of ecotoxicity, particularly across various trophic levels, including humans, is gaining increasing prominence as ecosystems face new threats and challenges. Computational ecotoxicological predictive approaches have already been deemed as a swifter and economical feasible answer. This work presents a new proposal in that context, integrating structure-based virtual screening and quantitative structure-activity relationship (QSAR) methodologies to address the ecotoxicity of per- and poly-fluoroalkyl substances (PFAS) in aquatic organisms, such as zebrafish. By focusing on the interaction between PFAS and the zebrafish mitochondrial voltage-dependent anion channel (zfVDAC2), resembling bioaccumulation in low concentrations, we analyzed 123 PFAS compounds. Our findings reveal that the top-ranked docked PFAS exhibits a predominant affinity for van der Waal interactions, followed by fluorine (F)-halogen bonds and hydrogen bonds interactions. The latter suggests that PFAS interaction strength may influence mitochondrial ATP transport via zfVDAC2. Similarly, the derived QSAR models identified packing density index, a descriptor linked to van der Waal interactions, as the most significant PFAS factor. Moreover, the high predictive power and statistical robustness of these models positioning them as valuable tools for environmental risk assessment in PFAS applications, while offering mechanistic insights into ecotoxicity.
Management of an extremely severe internal herniation in a 39-week pregnant female with a history of Roux-en-Y gastric bypass resulting in short bowel syndrome: a case report.
Authors: Poucke Evelien , Terryn Francois-Xavier , Devlieger Roland 
Published: July 2024

Abstract

Internal herniation (IH) is a common but potentially fatal complication (up to 10%) of gastric bypass which is often lately or misdiagnosed during pregnancy. While in non-pregnant bariatric patients, nausea, vomiting, and abdominal pain are red flags, these symptoms are frequently reported in normal pregnancies, therefore leading to serious treatment delays and possible life-threatening complications. Intestinal obstruction and volvulus can lead to necrosis and perforation within 8-16 hours. Previous reviews report higher risk of maternal (9%) and fetal (13.6%) death when diagnosis is delayed over 48 hours. The lack of clear clinical or laboratory findings and the reticence for radiologic imaging techniques during pregnancy delays diagnosis even more. If bowel necrosis is extended, bowel resection may be indicated, possibly leading to short bowel syndrome for life. Here, a rare case of short bowel syndrome is presented, requiring home parenteral nutrition (HPN) after extremely severe internal hernia at 39 weeks of pregnancy and several practical challenges encountered in the recognition and management of IH during pregnancy.
A case of Pierre Robin sequence in a child with multiple organ dysfunction
Authors: Pan HuiYi , Pan HuiYi 
Published: July 2024

Abstract

The Pierre Robin sequence (PRS) has an incidence rate of 1/20000 ~ 1/8500. Due to recurring lung infections and difficulty in swallowing, the patient was diagnosed with PRS after birth. The patient displayed multiple organ dysfunction, including the heart and kidneys, during the treatment. Subsequent treatment with mandibular lengthening device implantation, prone ventilation, and rehabilitation training improved the patient’s swallowing and breathing difficulties. However, the patient died due to severe lung infection and multiple organ dysfunction. Thus, timely surgery, oxygen therapy, rehabilitation visits, and strengthened nursing care can improve the quality of life of such children. Hence, further understanding of Pirot syndrome and entirely realizing the collaboration between multiple disciplines is necessary for jointly developing effective treatment plans for the disease.
Non-uniform flow and heat transfer characteristics and parametric study of generator hydrogen double-flow ring seal
Authors: Meng-Li ZHANG , Jiang Jinbo , Hong Jun , Xu Yongli , Meng Xiangkai , Peng Xudong 
Published: July 2024

Abstract

The double-flow floating ring seal is a key basic component to prevent crossflow between the hydrogen-cooled generator chamber and the bearing lubricating oil chamber of the hydrogen-cooled turbogenerator. Considering the relationship between lubricating oil physical properties and temperature, as well as the heat exchange between fluid domain and solid domain, the effect of oil physical property model and heat transfer model on the temperature rise and crossflow characteristics of double-flow ring seal were compared and analyzed. The quantitative characterization, formation mechanism, impact parameters and their interactive effects on the axial and circumferential non-uniform flow and heat transfer characteristics of the oil film in the sealing gap of double-flow ring seal were discussed in detail. The results show that the viscosity-temperature relationship of lubricating oil and the fluid-solid heat transfer have a significant impact on the flow and heat transfer characteristics of the ring seal. The oil flow in the sealing gap both on the air-side and hydrogen-side of the seal is closer to the adiabatic flow. Remarkble local high temperature rise region formed both at air-hydrogen section and hydrogen-side outlet, and it is sensitive to the pressure differential between oil inlet and outlet and axial length of sealing ring. The circumferential non-uniform pressure and temperature rise are mainly caused by eccentric clearance, and are highly sensitive to initial seal clearance and rotating speed. There is a strong interactive relationship among the temperature rise, crossflow and floating characteristics of the double-flow ring seal.
Development and In Vitro - In Vivo Evaluation of Composite Hydrogel-Forming Microneedles Containing Diclofenac Sodium with Box-Behnken Design Using SLA 3D-Printed Microneedle Molds
Authors: Tunçel Emre , Tort Serdar , Han Sevtap , Yücel Çiğdem , Tırnaksız Figen 
Published: July 2024

Abstract

With developing manufacturing technologies, the use of 3D printers in microneedle production is becoming widespread. In recent years, microneedles have gained considerable popularity as dermal drug delivery systems. Hydrogel-forming microneedles (HFMs), a variant of microneedles, demonstrate distinctive features such as a high loading capacity, controlled drug release, and enhanced drug absorption. In this study, the molds, created using a Stereolithography (SLA) 3D printer, were utilized to create composite HFMs containing diclofenac sodium. Using an experimental design approach (Box–Behnken Design), the effects of different polymers on the in vitro performance of the developed HFMs, as well as the impact of polymer mixtures on microneedle formation were investigated. The skin penetration and drug release properties of the proposed formulations were assessed. Ex vivo studies were conducted on formulations to determine drug penetration and accumulation in tissue, and the MTT testing revealed non-cytotoxicity. Subsequently, in in vivo studies, the efficacy of the optimal formulation was assessed for the treatment of xylene-induced ear edema by contrasting it to the conventional dosage form. As a result, it was observed that HFMs could provide high amounts of drug accumulation in the skin tissue.
Validation of 3D multiphase pyroclastic dilute current model: Effects of confinement on the flows
Authors: Tonoyama Shungo , Nakamura Takashi , Lube Gert 
Published: July 2024

Abstract

The volcanology community started to systematically test numerical models for pyroclastic density currents (PDCs) against benchmarks that are defined through large-scale experiments. Here, we present the results of a three-dimensional LES model for the case of a partially channel-confined, fully dilute, fully turbulent experimental PDC. Our LES model is based on solving the three- dimensional Navier-Stokes equations using a finite-difference method, CIP-CUP scheme. The model results are compared to the experimental benchmark and to the results of a previous validation of a one-dimensional depth-averaged model. To better understand the effect of three dimensionalities of the flow and entrainment of ambient air on flow evolution, we contrast two scenarios: (1) a fully channel-confined simulation, limiting lateral entrainment of air, and representing a three-dimensional scenario of the two-dimensional case, and (2) a partially confined simulation following the set-up geometry of the experimental benchmark. For the first case, the modelling results are similar to those obtained in the depth-averaged simulation, with a close agreement of the position of the flow front against time but showing a more prominent head shape and body height than the physical experiment. In the second case, the front velocity is slightly overpredicting. However, the height of the gravity current nose, the body thickness, and the vertical velocity profiles closely mimic those measured in the experiment. The downstream dilution of the PDCs is significantly enhanced in the partially confined scenario due to the formation of vortexes that laterally spill over the sidewalls, which is also seen in the large-scale experiment.
Impairment of Theta Oscillation in Hippocampus CA1 mediates age-dependent movements’ alternations in 5xFAD Mouse Model of Alzheimer's Disease
Authors: Ni Hong , Guo Zhongzhao , Wang Jie , Zhu Zilu , Xia Chenyi , Xu Ming , Zhang Guohui , Wang Deheng 
Published: July 2024

Abstract

Clinical evidences indicate that multifaceted gait abnormalities may manifest in Alzheimer's disease (AD) patients, which associated with cognitive decline. Although the correlation between hippocampal theta power and locomotion has been known for a long time, the mechanisms by how hippocampus impairment participates in the altered gait seen in AD is not fully understood. To explore the manifestations of gait disorders in AD, we characterized gait performance in 3-, 6-, and 9-month-old male 5xFAD and control mice in the semi-automated, highly sensitive, Catwalk XT system. The 5xFAD mice displayed a decrease in kinetic parameters (average speed and cadence), and spatial parameters (paw area), while the temporal parameters (stance and swing time) were significantly increased. The parameters of interlimb coordination also displayed deficits. The majority of impairment variables related to the slow speed in 5xFAD mice at 9-month-old. We further explored the theta oscillations in the brain by tetrode in vivo recording of the hippocampus CA1. The results showed that the theta oscillations reduced in the hippocampus CA1 of 5xFAD mice, which related to the gait impairments. In conclusion, gait impairments started at 6 months of age, manifested at 9 months of age in 5xFAD mice. A reduction in theta oscillation power of the hippocampus CA1 might be responsible for the gait impairments.
Purification and identification of hydrolyzed peptides from Lates calcarifer by-products and their anti-inflammatory function in lipopolysaccharide-induced RAW 264.7 macrophage cells
Authors: Cheng Ann-Chang , Liang Hua Yi , Balantyne Rolissa , Liu Chun-Hung 
Published: July 2024

Abstract

Fish by-product is considered a sustainable source for obtaining natural protein and hydrolysates with functional and biological activity. The present study explored the potential of barramundi, Lates calcarifer by-products as a natural source to generate bioactive peptides with anti-inflammatory properties in LPS-induced RAW264.7 macrophage cells. The results indicated that the highest degree of hydrolysis was achieved at 4% papain at a rate of 26.15 ± 2.67% in 48 hours. The hydrolyzed peptides had a total amino acid content of 51.55%, with essential and non-essential amino acids accounting for 27.28% and 24.27%, respectively. The active peptides were purified with ultrafiltration and Sephadex G-15 column. Eight peptide exhibited anti-inflammatroy properties were identified by using LC-MS/MS. Evaluation of anti-inflammatory peptides using the PreAIP database revealed high anti-inflammatory scores (0.501–0.659) for peptide sequences LKLLLL, KPKLLL, and LQLLL, and moderate scores (0.433–0.436) for peptide sequences LALDIEIATYR and LQLL, while GPVS, FGVS, and AMSP had lower scores (0.261–0.293). Molecular docking simulations revealed that two peptide sequences, LALDIEIATYR and LKLLLL, can effectively bind to Toll-like receptor (TLR4), with leucine playing a major role in receptor binding. The hydrolyzed peptides from barramundi by-products exhibit potential for improving the inflammatory response, as they effectively inhibited the production of proinflammatory cytokines such as IL-6, IL-1β, and TNF-α after LPS stimulation and increased the gene expression levels of anti-inflammatory factors such as IL-10 and IL-12. Therefore, the study suggests that the hydrolyzed peptides from barramundi by-products offer a promising therapeutic strategy for the treatment of inflammatory responses.
The effect of low molecular weight heparin on prognosis of patients with radical gastrectomy
Authors: Wei Yanqiang , Li Wenxing , Lin Jinhe , Wang Danfang , Dang Chengxue , Diao Dongmei , Zhang Xin 
Published: July 2024

Abstract

The safety and feasibility of perioperative anticoagulation remains unclear and controversial. In this study, we aim to explored whether postoperative anticoagulation with low molecular weight heparin (LMWH) can improve long-term survival in patients undergoing radical gastrectomy. We retrospectively enrolled 1486 patients diagnosed with primary gastric cancer (GC) and undergoing radical resection in our medical center between January 2015 and February 2018. Patients were grouped into anticoagulation group and non-anticoagulation group based on postoperative anticoagulant therapy, and clinicopathological features were collected and compared. The correlation between parameters and survival was assessed using the Kaplan-Meier method and univariate and multivariate COX regression models. Forest plots were constructed based on subgroup analysis and multivariate Cox regression analysis. Among the 1486 patients, 513 (34.5%) received postoperative anticoagulation therapy. In multivariate survival analysis, non-anticoagulation significantly reduced overall survival (OS), but not disease-free survival (DFS). Furthermore, elevated plasma CEA, CA19-9, lower erythrocyte and lymphocyte counts, and advanced N stage were also shown to be independent poor prognostic factors for OS, and they were also independent prognostic factors for DFS, in addition to lymphocyte counts. Anticoagulation with LMWH after radical gastrectomy can significantly improve the OS of GC patients.
The prognosis associated factors of chronic hepatitis C patients and a case report of resistance-associated substitutions to sofosbuvir-velpatavir treatment
Authors: Xiong Hao , Pan Shaokun , Zhou Zhaohui , Shi Hong , Xie Youhua , Guo Jinsheng 
Published: July 2024

Abstract

This study retrospectively analyzed the risk factors associated with liver cancer and cirrhosis in 358 HCV infected chinese patients with positive viral load. Among them, 80 patients treated with sofosbuvir-velpatavir (SOF-VEL) were further investigated for the efficacy and safety. An unusual SOF-VEL resistance case was investigated for the resistance-associated substitutions (RAS) using next-generation sequencing. HCV genotype 1 infection (45.5%) was most prevalent in this Chinese cohort. By single and multivariate factor analyses it was found that genotype 3 infection had a poorer prognosis. Age ≥50 years, male gender, Child-Pugh Grade B and C, and FIB-4 ≥3.25 were risk factors for liver cancer, while age ≥50 years, with diabetes, and ANA positive were risk factors for cirrhosis. Treating CHC patients with SOF-VEL revealed a sustained virologic response (SVR12) rate reaching 95%. The patient who experienced response-relapses once SOF-VEL was withdrawn had a HCV genotype 2a strain infection which harbored F28S mutation in NS5A, and T273A, M289L, A421V mutations in NS5B as RAS sites. We concluded thatSOF-VEL-basedpan-genotypic direct-acting antiviral treatment for CHC patients resulted in a high rate of achieving primary endpoint. However, the patients should be carefully monitored for SVR12 after the end of treatment.
On the effect of thermal expansion coefficient in prestressed concrete beams
Authors: Ruano Gonzalo , Quintana Virginia , Scala Armando La , Foti Dora 
Published: July 2024

Abstract

Prestressed concrete beams are commonly employed for building concrete slabs. These structures could be exposed to accidental fires and recently there has been a significant effort to understand how them perform under extreme load conditions. One key issue is the stress state of prestressed concrete beams subjected to thermal loads because stresses vary in time according to the temperature profile and are added to the prestressing process. For high temperature and transient thermo-mechanical analysis, temperature-dependent properties are extensively employed. Slender structures, like prestressed beams, are particularly sensitive to temperature changes, unlike the more robust cross-sections found in reinforced concrete. Particularly this paper analyses the structural influence of the coefficient of thermal expansion in slender structures subjected solely to high temperature through validation with experimental tests. Additionally, subjecting the structure only to a temperature rise does not overlap for other effects such as mechanical loads. The mechanical response of the tests under high temperature is noteworthy, and the finite element numerical analysis is used to properly capture the influence of the temperature-dependent coefficient of thermal expansion in these structures. A better understanding of this problem is achieved and structural engineers could be aware of the use of commonly used temperature-dependent properties into their assessments.