bluuebunny/crossref_metadata_2025_split huggingface dataset:
The right to education and attitudes toward Hijras in Bangladesh: assessing educational support to achieve sustainable communities
Authors: Kalam Abul , Alam Md Jahangir , Basharat Lubaba , Sarker Golam Faruk , Mamun M. Abdullah Al , Ahsan Abu Hossain Muhammad 
Published: August 2024

Purpose
This study aims to evaluate the current educational opportunities available to hermaphrodite (Hijra) students, analyze their difficulties while pursuing academic degrees and suggest potential approaches to address these issues.

Design/methodology/approach
This research used a qualitative method to analyze the challenges Hijra individuals face in pursuing education. A total of 20 interviews were conducted with two Hijra groups those who are pursuing an education and those who have abandoned it to collect primary data. The purposive sampling technique was used to identify and choose diverse sources of information. Moreover, the phenomena have been comprehended using the Access Theory and the Gender Stratification Theory.

Findings
The findings show that although every Bangladeshi has the right to a decent education, few Hijra youngsters attend schools. Numerous barriers, such as discriminatory views and remarks about third-gender people, physical and mental harassment, a lack of emotional and financial support, family issues, discrimination in the school community and hostility from classmates and teachers, make it difficult for hermaphrodite students to receive a proper education.

Originality/value
This research paper fills a gap in the current body of knowledge by presenting empirical evidence regarding young people’s perceptions of the third-gender, the societal barriers faced by Hijra individuals in their pursuit of quality education, their future opportunities, the root causes of these challenges and possible solutions.
Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes
Authors: Kitano Takamichi , Koiwai Toshikazu , Fujikawa Koki , Mori Sachi , Matsumoto Tatsumi , Sato Takashi 
Published: August 2024

AbstractAcne vulgaris is a complex condition involving factors that affect the pilosebaceous unit. A primary manifestation of acne pathology is the development of comedones, often linked to the overproduction of sebum resulting from 5α‐dihydrotestosterone (5α‐DHT) and insulin activity. Ozenoxacin is a topical quinolone that exhibits potent antibacterial activity against Cutibacterium acnes (C. acnes). It is commonly used to treat acne associated with this bacterium; however, its effect on sebum production within the sebaceous glands remains unclear. In this study, the effects of ozenoxacin on sebum production were examined using insulin‐ and 5α‐DHT‐differentiated hamster sebocytes. Ozenoxacin showed a dose‐dependent inhibition of lipid droplet formation and triacylglycerol (TG) production, which is a major component of sebum. In addition, it suppressed the expression of diacylglycerol acyltransferase 1, stearoyl‐CoA desaturase‐1, and perilipin‐1 mRNA, all important factors involved in sebum synthesis, in a dose‐dependent manner. Moreover, ozenoxacin decreased phosphorylated 40S ribosomal protein S6 levels downstream of the mechanistic/mammalian target of rapamycin complex 1 (mTORC1), without altering the phosphorylation of Akt, an upstream regulator of mTORC1, in both insulin‐ and 5α‐DHT‐treated hamster sebocytes. Interestingly, nadifloxacin, but not clindamycin, exhibited a similar suppression of sebum production, albeit with lesser potency compared with ozenoxacin. Furthermore, a topical application of a 2% ozenoxacin‐containing lotion to the auricle skin of hamsters did not affect the size of the sebaceous glands or epidermal thickness. Notably, it decreased the amount of TG on the skin surface. The results provide novel insights into the sebum‐inhibitory properties of ozenoxacin, indicating its potential efficacy in controlling microbial growth and regulating sebum production for acne management.
Antecedents of sustainable agricultural supply chain financing for achieving food security in resource‐constrained developing economies: A complex adaptive systems theory perspective
Authors: Muntaka Abdul Samed , Apike Isaac Akurugu , Antwi David 
Published: August 2024

AbstractThe aim of this research is to examine what antecedents of supply chain financing (SCF) should be overcome to ensure that the agricultural supply chain from preplanting to postharvesting generates enough food to achieve sustainable food security in developing countries. Drawing from complex adaptive systems (CAS) theory, we develop and test a model of how a prospective and challenging financing scheme navigates complex social and repayment systems to achieve sustainable SCF. The results of the study show that a challenging financing scheme must navigate complex social and repayment systems to achieve sustainable SCF, while a prospective financing scheme even though it shows a positive influence on sustainable SCF, its effect is higher when it is able to navigate these. The study hence concludes that for agricultural SCF schemes to lead to sustainable food security, they must be accessible and appropriate to the needs of the community, overcome default risk and cumbersome financial arrangements and be able to navigate the complex social and repayment systems. The study recommends that financing schemes should establish proximity to farming communities and engage farmers to determine appropriate funds for different stages among others.
Emotion Regulation, Relationship and Therapeutic Change in Analytical Psychology and Contemporary Psychodynamic Approaches
Authors: Roesler Christian 
Published: August 2024

AbstractAll contemporary psychotherapies agree that (failing) emotion regulation is central to psychological disorders and that psychotherapy is about improving emotion regulation. In his research on the “emotion‐laden” complex Jung put an emphasis on the role of failing emotion regulation in contributing to psychological disorders as well as to change in the process of psychotherapy, but he left this field of research and took a very different direction in favour of his archetype concept. Psychodynamic approaches generally argue that changes in emotion regulation are accomplished through corrective emotional experiences in the therapeutic relationship. Insights from affective neurosciences and attachment research have had a major influence on how the therapeutic relationship is constructed in contemporary psychodynamic approaches. There is a lack of similar developments in analytical psychology, which leads to substantial differences between the models of Jungian psychotherapy in contrast to other contemporary psychodynamic approaches. The implications of these differences for the practice of psychotherapy and especially the role of the therapeutic relationship are pointed out.
Risk factors for older people re‐presenting to the emergency department with falls: A case–control analysis
Authors: San Juan Charlene , Appiah‐Kubi Linda , Mitropoulos Joanna , Thomson Lorne , Demosthenous Athena , Kelly Anne‐Maree 
Published: August 2024

AbstractObjectiveFalls are a leading cause for ED presentations among older adults. Existing secondary falls prevention interventions have not been shown to decrease fall‐related ED re‐presentation, indicating a need to better understand contributing factors. Our aim was to evaluate risk factors for fall re‐presentations among the older patient population presenting to the ED.MethodsThis is a single‐centre case–control study. Cases were patients aged ≥65 years with two falls‐related ED presentations within 6 months. Age‐ and sex‐matched controls had a corresponding index, but no subsequent ED fall presentation. Data collected included falls risk factors and clinical features of the index presentation. Univariate and multivariate analyses were conducted to assess the relationship between potential exposures and fall re‐presentation.ResultsA total of 300 patients (mean age 83.8 years) were studied. On univariate analysis, factors significantly associated with ED fall re‐presentation included increasing multimorbidity (P < 0.0001), increasing number of medications (P < 0.0001) and residing in residential aged care facility (RACF) (odds ratio [OR] 3.06, P < 0.001). No factors remained significant on multivariate analysis. Post‐hoc analyses for the RACF subgroup showed that psychotropic medication use (OR 1.65, P = 0.04) and prior fall within 12 months (OR 2.68, P < 0.001) were significantly associated with re‐presentation. Initial presentation with serious musculoskeletal injury was a significant protective factor (OR 0.21, P = 0.02).ConclusionThe present study failed to identify factors independently associated with ED fall re‐presentation, suggesting that the factors are complex and inter‐related. Two high‐risk populations were identified – those from RACF and those initially presenting with falls not resulting in serious injury.
Inactivation kinetics for surrogates of common foodborne pathogens during food residue drying
Authors: Shea Emily , Toniato Juliano , Simmons Christopher 
Published: August 2024

AbstractPostconsumer household food residues can act as useful substrates for other industries, but transporting high‐moisture material corresponds to high fuel use and associated greenhouse gas production. Drying food residues at the household level reduces transportation weight, increases stability, and preserves the nutritional quality of recovered material. Mitigating foodborne microbiological safety risks is crucial to encourage the development of novel methods to rapidly dry and stabilize food residues. The objective of this study was to improve the prediction of bacterial pathogen inactivation under various thermal and drying processes in a synthetic mixture of residual food material (RFM). The log reduction rate was measured for Escherichia coli, Enterococcus faecium, and Listeria innocua (surrogates of common foodborne pathogens) in RFM under different moisture contents (12% and 25% by fresh weight) and temperatures (50, 55, and 60°C). Inactivation data were used to determine D‐ and z‐values and to fit a multiple regression model to predict log(D‐values) in response to temperature and moisture content. Across conditions, D‐values were measured to be 5.1–120, 4.6–123, and 32–545 min for E. coli, L. innocua, and E. faecium, respectively. Temperature sensitivities were significantly higher in lower moisture RFM for E. coli and L. innocua. Applying E. coli inactivation models during RFM at 55°C yielded inactivation rates that aligned with experimental values after 5 min (0.1 vs. 0–0.1 logs), 30 min (2.1 vs. 1.3–2.3 logs), and 90 min (7.2 vs. 7.1–8.9 logs). These results can inform the design of RFM drying and stabilization processes to promote pathogen inactivation and safety in downstream applications of dried material.
Efficacy of first‐line immune checkpoint inhibitor and anti‐angiogenic agent combination therapy for Kirsten rat sarcoma viral antigen‐mutant advanced non‐small‐cell lung cancer: a systematic review and network meta‐analysis
Authors: Tsukada Akinari , Morita Chie , Shimizu Yosuke , Uemura Yukari , Naka Go , Takasaki Jin , Nokihara Hiroshi , Izumi Shinyu , Hojo Masayuki 
Published: August 2024

AbstractBackgroundRecent advancements in advanced non‐small‐cell lung cancer (NSCLC) treatment have significantly improved primary therapy outcomes owing to the emergence of various molecular targeted therapies and immune checkpoint inhibitors (ICIs). However, for Kirsten rat sarcoma viral antigen (KRAS) mutations, molecular targeted drugs, such as sotorasib, are not applicable as first‐line treatments, and the optimal primary treatment remains unclear. Therefore, we aimed to investigate the efficacy of ICI combination therapy as first‐line treatment for KRAS‐mutant NSCLC.MethodsWe conducted a systematic search for phase 3 randomized controlled trials (RCTs) that presented data on KRAS mutation status in advanced NSCLC. The primary endpoints were progression‐free survival (PFS) and overall survival (OS). A random‐effects network meta‐analysis was conducted to perform direct and indirect comparisons among treatment groups.ResultsSix RCTs were eligible for inclusion. In the network meta‐analysis for KRAS‐mutant NSCLC, Chemo + bevacizumab (Bev) + ICI was associated with improved PFS (hazard ratio [HR] 0.38, 95% confidence interval [CI] 0.22–0.64), followed by Chemo + ICI + ICI (HR 0.66, 95% CI 0.47–0.93) and Chemo + ICI (HR 0.67, 95% CI 0.49–0.91). The most beneficial effect on OS was observed with Chemo + Bev + ICI (HR 0.50, 95% CI 0.34–0.73), followed by Chemo + ICI + ICI (HR 0.64, 95% CI 0.48–0.87) and Chemo + ICI (HR 0.72, 95% CI 0.56–0.92). Regarding OS in wild‐type KRAS, ICI + ICI (HR 0.73, 95% CI 0.50–1.07) produced the most favorable effects, followed by Chemo + ICI (HR 0.79, 95% CI 0.63–0.99).ConclusionThe efficacy of Chemo + Bev + ICI is potentially high for improving PFS and OS in KRAS‐mutant NSCLC. In advanced NSCLC, the presence or absence of KRAS mutations may need to be considered when administering first‐line treatment.
Biological control of cat's claw creeper (Dolichandra unguis‐cati; Bignoniaceae): Current status and future prospects
Authors: Dhileepan Kunjithapatham , King Anthony M. , Taylor Dianne B. J. , Pollard Kathryn M. , Seier Marion K. 
Published: August 2024

AbstractCat's claw creeper (Dolichandra unguis‐cati), native to tropical South America, is a major invasive species and a target for biological control in Australia, South Africa and some South Pacific Island countries. Native range surveys in Argentina, Brazil, Paraguay and Venezuela have identified eight insects and four fungal pathogens as potential agents. Five leaf‐feeding insects a tortoise beetle Charidotis auroguttata, two tingids Carvalhotingis visenda and C. hollandi, a leaf‐tying moth Hypocosmia pyrochroma and a leaf‐mining beetle Hedwigiella jureceki, have been tested and all were released in South Africa. Four of these have become established but are not widespread and cause only limited damage. In Australia, only three of these, C. visenda, H. pyrochroma and H. jureceki were released, while C. auroguttata was not approved due to perceived non‐target risks. All agents have become widely established, except for H. pyrochroma which is restricted to riparian corridors in southeast Queensland. In South Africa, an accidentally introduced leaf‐spot pathogen, Neoramulariopsis unguis‐cati, causes necrotic lesions and premature abscission of leaves in cat's claw creeper infestations, resulting in widespread defoliation. Based on its impact and field‐host specificity in its native range and in South Africa, the pathogen has been prioritised for evaluation as a potential additional agent in Australia. The current priority is to seek approval for the introduction of this leaf‐spot pathogen into Australia. Future research should focus on the gall‐inducing rust Uropyxis rickiana and the seed‐feeding weevil Apteromechus notatus as prospective agents.
Kv7 channel opener retigabine reduces self‐administration of cocaine but not sucrose in rats
Authors: Urena Esteban S. , Diezel Cody C. , Serna Mauricio , Hala'ufia Grace , Majuta Lisa , Barber Kara R. , Vanderah Todd W. , Riegel Arthur C. 
Published: August 2024

AbstractThe increasing rates of drug misuse highlight the urgency of identifying improved therapeutics for treatment. Most drug‐seeking behaviours that can be modelled in rodents utilize the repeated intravenous self‐administration (SA) of drugs. Recent studies examining the mesolimbic pathway suggest that Kv7/KCNQ channels may contribute to the transition from recreational to chronic drug use. However, to date, all such studies used noncontingent, experimenter‐delivered drug model systems, and the extent to which this effect generalizes to rats trained to self‐administer drugs is not known. Here, we tested the ability of retigabine (ezogabine), a Kv7 channel opener, to regulate instrumental behaviour in male Sprague Dawley rats. We first validated the ability of retigabine to target experimenter‐delivered cocaine in a conditioned place preference (CPP) assay and found that retigabine reduced the acquisition of place preference. Next, we trained rats for cocaine‐SA under a fixed‐ratio or progressive‐ratio reinforcement schedule and found that retigabine pretreatment attenuated the SA of low to moderate doses of cocaine. This was not observed in parallel experiments, with rats self‐administering sucrose, a natural reward. Compared with sucrose‐SA, cocaine‐SA was associated with reductions in the expression of the Kv7.5 subunit in the nucleus accumbens, without alterations in Kv7.2 and Kv7.3. Therefore, these studies reveal a reward‐specific reduction in SA behaviour and support the notion that Kv7 is a potential therapeutic target for human psychiatric diseases with dysfunctional reward circuitry.
A narrative review of the literature: The role of biologics and JAK inhibitors in vitiligo
Authors: Russell Rhiannon , Daniel Benjamin S. 
Published: August 2024

AbstractVitiligo is a chronic depigmenting disorder that significantly impacts the quality of life of patients. Though there have been significant advancements in targeted therapies in skin diseases such as psoriasis or eczema, the progress in the treatment of vitiligo has been slow, with minimal studies assessing the effect of biologics, though there has been recent evidence of the effectiveness of JAK inhibition. This paper reviews the published case reports and studies for the use of systemic targeted therapies including biologics and JAK inhibitors in vitiligo.
The cardiovascular risk in bullous pemphigoid: Insights from a population‐based study
Authors: Kridin Khalaf , Goychberg Rina , Kridin Mouhammad , Kafri Niv , Barhoum Masad , Cohen Arnon D. 
Published: August 2024

AbstractBackgroundThe risk of life‐threatening major cardiovascular outcomes among patients with bullous pemphigoid (BP) is inconsistent in the current literature.ObjectiveTo evaluate the risk and prognostic outcomes of myocardial infarction (MI), cerebrovascular accident (CVA), peripheral vascular disease (PVD) and pulmonary embolism (PE) in patients with BP. We additionally aimed to explore the influence of different therapeutic approaches on the risk of these outcomes.MethodsA population‐based retrospective cohort study was conducted to compare BP patients (n = 3924) with age‐, gender‐ and ethnicity‐matched control subjects (n = 19,280) with regard to incident cases of MI, CVA, PVD and PE. Adjusted hazard ratio (HR) and 95% confidence intervals (CI) were estimated by multivariate Cox regression analysis. Data were retrieved from Clalit Health Services' computerized database.ResultsRelative to their matched controls, patients with BP were at an elevated risk of MI (fully‐adjusted HR: 1.44; 95% CI: 1.14–1.81; p = 0.002), CVA (fully‐adjusted HR: 1.24; 95% CI: 1.06–1.45; p = 0.007), PVD (fully‐adjusted HR: 1.60; 95% CI: 1.27–2.03; p = 0.003) and PE (fully‐adjusted HR: 1.72; 95% CI: 1.28–2.32; p < 0.008). Patients with BP experienced heightened risk of all‐cause mortality in the presence of comorbid MI (fully‐adjusted HR: 1.61; 95% CI: 1.44–1.81; p < 0.001), CVA (fully‐adjusted HR: 1.70; 95% CI: 1.52–1.89; p < 0.001), PVD (fully‐adjusted HR: 1.38; 95% CI: 1.20–1.58; p < 0.001) and PE (fully‐adjusted HR: 1.44; 95% CI: 1.10–1.88; p = 0.007). The therapeutic approach utilized to manage BP did not significantly influence the risk of cardiovascular outcomes.ConclusionsBP is associated with an elevated risk of MI, CVA, PVD, PE and cardiovascular mortality. Primary, secondary and tertiary cardiovascular prevention measures should be implemented among patients with BP.
Transhumance Urbanism as an Urban Otherwise: Inhabiting Agrarian Incompletion at the Intersections of Extended Urbanisation‐Extended Ruralisation
Authors: Bathla Nitin 
Published: August 2024

AbstractAmid the ongoing transformation of agrarian territories in peripheral geographies across the world through extended urbanisation, this paper delves into the persistence of peasant and pastoral strategies amidst the closing down effects of land enclosure and fragmentation. Based on ethnographic research conducted with transhumant pastoralists in Delhi National Capital Region, this paper finds that instead of diminishing under agrarian‐urban transformation, pastoralists reassign use value to the fallows, wastelands, and surpluses of real estate speculation, thereby crafting a transhumance urbanism beyond the sedentary ontology of land and property. Understood as an urban otherwise, this urbanism remakes the fragments of material incompletion inherent within the agrarian‐urban transformation, offering socio‐ecological alternatives beyond the current impasse. The paper discusses the tentative, unsettled, and transient nature of this urbanism, which is always inter‐mixed with its non‐urban other. Contributing further to the scholarship emerging at the interstices of urban and agrarian studies, this paper calls for further comparative research on the territorial adaptation of peasant and pastoral populations routinely excluded from capitalist urbanisation processes unfolding in peripheral regions where sizeable itinerant populations coexist with extreme pressures of land enclosure.
Diuresis‐led volume replacement strategy in extremely low birth weight infants
Authors: Salloum Jonas Abbas , Garten Lars , Bührer Christoph 
Published: August 2024

AbstractAimIn extremely low birth weight infants, fluid overload has been associated with bronchopulmonary dysplasia and death. Excessive weight loss may increase the risk of meconium obstruction and intestinal perforation. As these infants display oliguria followed by polyuria, we embarked on a diuresis‐led volume replacement strategy as of January 2020.MethodsThis single‐centre analysis presents data of infants <1000 g birth weight surviving for more than 3 days admitted 2017–2019 (n = 217, daily volume increase) versus 2020–2022 (n = 2022, diuresis‐led volume replacement).ResultsThe second cohort had lower gestational age (median [interquartile range]: 253/7 [243/7–264/7] vs. 263/7 [251/7–282/7] weeks), less antenatal steroids (58% vs. 69%), more indomethacin (66% vs. 47%) and higher initial diuresis (5.6 [4.9–6.8] vs. 4.8 [4.2–5.5] mL/kg/h) but did not differ by relative weight loss at Day 7 of life. Employing binary logistic regression with gestational age, antenatal steroids and indomethacin as covariates, the cohorts did not differ by rates of patent ductus arteriosus, abdominal surgery or severe retinopathy of prematurity, while there were significant declines in sepsis (from 32% to 19%), bronchopulmonary dysplasia (from 26% to 23%) and mortality (from 13% to 7%).ConclusionDiuresis‐led volume replacement appears to be safe and maybe beneficial.