bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal transsulfuration metabolism and reduced antioxidant capacity in Chinese children with autism spectrum disorders
Authors: Han Yu , Xi Qian‐qian , Dai Wei , Yang Shu‐han , Gao Lei , Su Yuan‐yuan , Zhang Xin 
Published: July 2015

AbstractAutism spectrum disorder (ASD) is a neurological disorder that presents a spectrum of qualitative impairments in social interaction, communication, as well as restricted and stereotyped behavioral patterns, interests, and activities. Several studies have suggested that the etiology of ASD can be partly explained by oxidative stress. However, the implications of abnormal transsulfuration metabolism and oxidative stress, and their relation with ASD are still unclear. The purpose of this study was to evaluate several transsulfuration pathway metabolites in Chinese participants diagnosed with ASD, to better understand their role in the etiology of this disorder. Fifty children (39 male, 11 female) diagnosed with ASD and 50 age‐ and gender‐matched non‐ASD children (i.e., control group) were included in this study. This prospective blinded study was undertaken to assess transsulfuration and oxidative metabolites, including levels of homocysteine (Hcy), cysteine (Cys), total glutathione (tGSH), reduced glutathione (GSH), oxidized glutathione (GSSG), and glutathione ratio (GSH/GSSG). The clinical severity of ASD was evaluated with the Childhood Autism Rating Scale (CARS), and the autistic children's present behavior was measured by the Autism Behavior Checklist (ABC). The results indicated that Hcy and GSSG levels were significantly higher in children diagnosed with ASD, Cys, tGSH and GSH levels as well as the GSH/GSSG ratio showed remarkably lower values in ASD children compared to control subjects. Hcy levels correlated significantly with increasing CARS scores and GSSG levels in children with ASD. Our results suggest that an abnormal transsulfuration metabolism and reduced antioxidant capacity (i.e., hyperhomocysteinemia and increased oxidative stress), and Hcy level appears to have a potentially negative impact on clinical severity of autistic disorder.
Programming of adaptive repair process chains using repair features and function blocks
Authors: Spöcker Gunter , Schreiner Thorsten , Huwer Tobias , Arntz Kristian 
Published: July 2015

Abstract
The current trends of product customization and repair of high value parts with individual defects demand automation and a high degree of flexibility of the involved manufacturing process chains. To determine the corresponding requirements this paper gives an overview of manufacturing process chains by distinguishing between horizontal and vertical process chains. The established way of modeling and programming processes with CAx systems and existing approaches is shown. Furthermore, the different types of possible adaptions of a manufacturing process chain are shown and considered as a cascaded control loop. Following this it is discussed which key requirements of repair process chains are unresolved by existing approaches. To overcome the deficits this paper introduces repair features which comprise the idea of geometric features and defines analytical auxiliary geometries based on the measurement input data. This meets challenges normally caused by working directly on reconstructed geometries in the form of triangulated surfaces which are prone to artifacts. Embedded into function blocks, this allows the use of traditional approaches for manufacturing process chains to be applied to adaptive repair process chains.
Highlights Definition of adaptive repair process chains as cascaded control loops. Introduction of repair features as a bridge between measurement input and analytical CAD data for manufacturing. Dynamic determination and adjustment of repair features and CAx repair process chain execution based on function blocks. Use case study of repairing worn-out turbine blades with repair features and function blocks.
Assessment of subjective well-being and quality of life in patients with intestinal stoma
Authors: Salomé Geraldo Magela , de Almeida Sergio Aguinaldo , Mendes Bruno , de Carvalho Maiume Roana Ferreira , Massahud Junior Marcelo Renato 
Published: July 2015

AbstractObjective To investigate the subjective well-being and quality of life in patients with intestinal stoma.Method This study was conducted at Ostomized People's Pole of Pouso Alegre. Data were collected in the period between December 2012 and May 2013, after approval by the Ethics Committee of the Universidade do Vale do Sapucaí under opinion No. 23,277. The participants were selected by a convenience non-probability sampling. The following instruments were used: a questionnaire on demographics and stoma; a Subjective Well-being Scale; and a Quality Outcome Scale.Results Regarding the Flanagan Quality of Life Scale, 16–22 points were obtained, indicating that these patients suffered changes in their quality of life. Regarding the scale of subjective well-being in three domains: positive affect – 43 (61.40%) individuals; negative affect – 31 (44.30%) individuals; and life satisfaction – 54 (77.10%), all subjects obtained a score of 3, characterizing a negative change in these domains. The mean Flanagan Quality of Life Scale score was 26.16, and the means for the domains included in the Subjective Well-being Scale were: positive affect: 2.51; negative affect: 2.23 and life satisfaction: 2.77, indicating that the intestinal stoma users who participated in the study had negative feelings related to their own self-esteem and to the loss of quality of life.Conclusion Patients with intestinal stoma who participated in this study had a change in their quality of life and in subjective well-being.
Transanal Endoscopic Proctectomy: a new approach to the total excision of the mesorectum
Authors: Mendes Carlos Ramon Silveira , de Miranda Ferreira Luciano Santana , Sapucaia Ricardo Aguiar , Lima Meyline Andrade , Cobas Eduardo Costa , Araujo Sergio Eduardo Alonso 
Published: July 2015

Abstract
Introduction Colorectal cancer is a serious public health problem. In 1982, Heald managed to reduce mortality by standardizing the total excision of mesorectum. The use of transanal endoscopic microsurgery has emerged to allow resection of rectal tumors as a minimally invasive method. With the association of Transanal Endoscopic Operation with total excision of mesorectum, it was possible to develop a new approach for total excision of mesorectum.
Surgical technique The procedure is started by the perineal time with Transanal Endoscopic Operation device; introduction of Transanal Endoscopic Operation system follows, with exposure of the lesion with a circumferential incision at a distance between 2 and 4 cm from distal tumor margin after making a purse string suture to close the rectal stump. Then, dissection is carried out by the posterior portion until reaching the presacral avascular fascia, completing the mesorectal circumferential dissection until the peritoneal reflection. After this step, a laparoscopic procedure is performed with the use of three trocars, with mobilization of splenic flexure and ligation of the inferior mesenteric artery, as well as confection of a protective ileostomy. Then, transanal removal of the surgical specimen is performed, and the procedure goes on with a coloanal anastomosis.
Treatment of Patellar Tendinopathy Refractory to Surgical Management Using Percutaneous Ultrasonic Tenotomy and Platelet‐Rich Plasma Injection: A Case Presentation
Authors: Nanos Katherine N. , Malanga Gerard A. 
Published: July 2015

AbstractChronic proximal patellar tendinopathy is a common condition in sports medicine that may be refractory to nonoperative treatments, including activity modification, medications, and comprehensive rehabilitation. Percutaneous ultrasonic tenotomy is a recently developed technique designed to cut and debride tendinopathic tissue, thus promoting pain relief and functional recovery. We present a case of a collegiate athlete with chronic proximal patellar tendinopathy who was effectively treated with percutaneous ultrasonic tenotomy after not responding to extensive nonoperative treatment, surgical debridement, and platelet‐rich plasma injections. Percutaneous ultrasonic tenotomy can be considered as a treatment option in patients presenting with refractory proximal patellar tendinopathy, including those who do not respond to previous operative intervention.
PSIKO2: a fast and versatile tool to infer population stratification on various levels in GWAS
Authors: Popescu Andrei-Alin , Huber Katharina T. 
Published: July 2015

Abstract
Summary: Genome-wide association studies are an invaluable tool for identifying genotypic loci linked with agriculturally important traits or certain diseases. The signal on which such studies rely upon can, however, be obscured by population stratification making it necessary to account for it in some way. Population stratification is dependent on when admixture happened and thus can occur at various levels. To aid in its inference at the genome level, we recently introduced psiko, and comparison with leading methods indicates that it has attractive properties. However, until now, it could not be used for local ancestry inference which is preferable in cases of recent admixture as the genome level tends to be too coarse to properly account for processes acting on small segments of a genome. To also bring the powerful ideas underpinning psiko to bear in such studies, we extended it to psiko2, which we introduce here.
Availability and implementation: Source code, binaries and user manual are freely available at https://www.uea.ac.uk/computing/psiko.
Contact: Andrei-Alin.Popescu@uea.ac.uk or Katharina.Huber@cmp.uea.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.
The Arab Legion and the 1948 War: The Conduct of ‘Collusion’?
Authors: Jevon Graham 
Published: July 2015

Abstract
The partition of Palestine and the 1948 Arab-Israeli War proved to be one of the defining moments of the twentieth century and its continued contemporary resonance has helped maintain a lively historiography. One of the key contentions remains the question of ‘collusion’ between the Hashemite Kingdom of Transjordan and the Zionists, with the approval of Britain, to partition Palestine in contravention of the UN partition plan. Based on unprecedented access to the unofficial archive of the strongest of the Arab armies—Transjordan’s Arab Legion—this article seeks to further the debate by examining the conduct of the Arab Legion, during the first half of 1948. This new material has enabled a more thorough assessment of the Arab Legion’s aims and actions than ever before. In so doing, this article dampens the revisionist notion of a firm or even tacit Hashemite–Zionist agreement, but nonetheless supports the revisionist argument that negotiations between the parties helped to shape the 1948 war. It reveals that the Arab Legion was used to establish Hashemite–Zionist partition by occupying the Arab areas of Palestine when the mandate ended and acquiescing in the establishment of Israel. Moreover, this article illustrates a significant nuance, concerning the intense fighting that took place, particularly in Jerusalem, after the end of the mandate, differentiating between the influence of King Abdullah of Transjordan and the British commander of his army, Glubb Pasha, in dictating the Arab Legion’s conduct.
Histone H2B Monoubiquitination Mediated by HISTONE MONOUBIQUITINATION1 and HISTONE MONOUBIQUITINATION2 Is Involved in Anther Development by Regulating Tapetum Degradation-Related Genes in Rice
Authors: Cao Hong , Li Xiaoying , Wang Zhi , Ding Meng , Sun Yongzhen , Dong Fengqin , Chen Fengying , Liu Li’an , Doughty James , Li Yong , Liu Yong-Xiu 
Published: July 2015

Abstract
Histone H2B monoubiquitination (H2Bub1) is an important regulatory mechanism in eukaryotic gene transcription and is essential for normal plant development. However, the function of H2Bub1 in reproductive development remains elusive. Here, we report rice (Oryza sativa) HISTONE MONOUBIQUITINATION1 (OsHUB1) and OsHUB2, the homologs of Arabidopsis (Arabidopsis thaliana) HUB1 and HUB2 proteins, which function as E3 ligases in H2Bub1, are involved in late anther development in rice. oshub mutants exhibit abnormal tapetum development and aborted pollen in postmeiotic anthers. Knockout of OsHUB1 or OsHUB2 results in the loss of H2Bub1 and a reduction in the levels of dimethylated lysine-4 on histone 3 (H3K4me2). Anther transcriptome analysis revealed that several key tapetum degradation-related genes including OsC4, rice Cysteine Protease1 (OsCP1), and Undeveloped Tapetum1 (UDT1) were down-regulated in the mutants. Further, chromatin immunoprecipitation assays demonstrate that H2Bub1 directly targets OsC4, OsCP1, and UDT1 genes, and enrichment of H2Bub1 and H3K4me2 in the targets is consistent to some degree. Our studies suggest that histone H2B monoubiquitination, mediated by OsHUB1 and OsHUB2, is an important epigenetic modification that in concert with H3K4me2, modulates transcriptional regulation of anther development in rice.
Synergistic Effect of Sodium Chlorite and Edible Coating on Quality Maintenance of Minimally Processed Citrus grandis under Passive and Active MAP
Authors: Ban Zhaojun , Feng Jianhua , Wei Wenwen , Yang Xiangzheng , Li Jilan , Guan Junfeng , Li Jiang 
Published: July 2015

AbstractEdible coating has been an innovation within the bioactive packaging concept. The comparative analysis upon the effect of edible coating, sodium chlorite (SC) and their combined application on quality maintenance of minimally processed pomelo (Citrus grandis) fruits during storage at 4 °C was conducted. Results showed that the combination of edible coating and SC dipping delayed the microbial development whereas the sole coating or dipping treatment was less efficient. The synergetic application of edible coating and SC treatment under modified atmosphere packaging (MAP, 10% O2, 10% CO2) was able to maintain the total soluble solids level and ascorbic acid content, while reduce the weight loss as well as development of mesophiles and psychrotrophs. Nonetheless, the N, O‐carboxymethyl chitosan solely coated samples showed significantly higher level of weight loss during storage with comparison to the untreated sample. Furthermore, the combined application of edible coating and SC dipping under active MAP best maintained the sensory quality of minimally processed pomelo fruit during storage.
Role of Heavy Meromyosin in Heat‐Induced Gelation in Low Ionic Strength Solution Containing l‐Histidine
Authors: Hayakawa Toru , Yoshida Yuri , Yasui Masanori , Ito Toshiaki , Wakamatsu Jun‐ichi , Hattori Akihito , Nishimura Takanori 
Published: July 2015

AbstractThe gelation of myosin has a very important role in meat products. We have already shown that myosin in low ionic strength solution containing l‐histidine forms a transparent gel after heating. To clarify the mechanism of this unique gelation, we investigated the changes in the nature of myosin subfragments during heating in solutions with low and high ionic strengths with and without l‐histidine. The hydrophobicity of myosin and heavy meromyosin (HMM) in low ionic strength solution containing l‐histidine was lower than in high ionic strength solution. The SH contents of myosin and HMM in low ionic strength solution containing l‐histidine did not change during the heating process, whereas in high ionic strength solution they decreased slightly. The heat‐induced globular masses of HMM in low ionic strength solution containing l‐histidine were smaller than those in high ionic strength solution. These findings suggested that the polymerization of HMM molecules by heating was suppressed in low ionic strength solution containing l‐histidine, resulting in formation of the unique gel.
Classification of Sunflower Oil Blends Stabilized by Oleoresin Rosemary (Rosmarinus officinalis L.) Using Multivariate Kinetic Approach
Authors: Upadhyay Rohit , Mishra Hari Niwas 
Published: July 2015

AbstractThe sunflower oil–oleoresin rosemary (Rosmarinus officinalis L.) blends (SORB) at 9 different concentrations (200 to 2000 mg/kg), sunflower oil–tertiary butyl hydroquinone (SOTBHQ) at 200 mg/kg and control (without preservatives) (SOcontrol) were oxidized using Rancimat (temperature: 100 to 130 °C; airflow rate: 20 L/h). The oxidative stability of blends was expressed using induction period (IP), oil stability index and photochemiluminescence assay. The linear regression models were generated by plotting ln IP with temperature to estimate the shelf life at 20 °C (SL20; R2 > 0.90). Principal component analysis (PCA) and hierarchical cluster analysis (HCA) was used to classify the oil blends depending upon the oxidative stability and kinetic parameters. The Arrhenius equation adequately described the temperature‐dependent kinetics (R2 > 0.90, P < 0.05) and kinetic parameters viz. activation energies, activation enthalpies, and entropies were calculated in the range of 92.07 to 100.50 kJ/mol, 88.85 to 97.28 kJ/mol, −33.33 to −1.13 J/mol K, respectively. Using PCA, a satisfactory discrimination was noted among SORB, SOTBHQ, and SOcontrol samples. HCA classified the oil blends into 3 different clusters (I, II, and III) where SORB1200 and SORB1500 were grouped together in close proximity with SOTBHQ indicating the comparable oxidative stability. The SL20 was estimated to be 3790, 6974, and 4179 h for SOcontrol, SOTBHQ, and SORB1500, respectively. The multivariate kinetic approach effectively screened SORB1500 as the best blend conferring the highest oxidative stability to sunflower oil. This approach can be adopted for quick and reliable estimation of the oxidative stability of oil samples.
Cytomegalovirus and other common enteric viruses are not commonly associated with NEC
Authors: Skeath Thomas , Stewart Christopher , Waugh Sheila , Embleton Nicholas , Cummings Stephen , Berrington Janet 
Published: July 2015

AbstractAimChanges in gut microbiota may contribute to NEC, but most studies focus on bacteria. Case reports suggest a link between cytomegalovirus (CMV) or other enteric viruses and NEC, but there are few case series systematically looking at common potential viral causes. We aimed to assess the presence of candidate viruses in blood or stool of a case series of infants with NEC managed in one surgical centre.MethodsWe identified 22 infants diagnosed with NEC (from November 2011 to March 2014): 17 had suitable blood stored, of whom 14 also had suitable stool samples stored. Blood was analysed with polymerase chain reaction (PCR) for CMV, Epstein–Barr virus (EBV) and adenovirus, and stool by PCR for norovirus, sappovirus, astrovirus, adenovirus and rotavirus.ResultsAll samples were negative.ConclusionAlthough case reports indicate an episodic association of enteric viruses in NEC, the inability to detect any of these viruses in our 17 NEC infants suggests that a viral aetiology is unlikely to be causative for most sporadic forms of NEC.
Social media and pharmacovigilance: A review of the opportunities and challenges
Authors: Sloane Richard , Osanlou Orod , Lewis David , Bollegala Danushka , Maskell Simon , Pirmohamed Munir 
Published: July 2015

AbstractAdverse drug reactions come at a considerable cost on society. Social media are a potentially invaluable reservoir of information for pharmacovigilance, yet their true value remains to be fully understood. In order to realize the benefits social media holds, a number of technical, regulatory and ethical challenges remain to be addressed. We outline these key challenges identifying relevant current research and present possible solutions.
Growth hormone replacement does not increase mortality in patients with childhood‐onset growth hormone deficiency
Authors: Berglund Agnethe , Gravholt Claus Højbjerg , Olsen Morten Smærup , Christiansen Jens Sandahl , Stochholm Kirstine 
Published: July 2015

SummaryContextLong‐term safety of growth hormone (GH) treatment is an area of much debate. Studies including children treated with GH not only due to GHD, but also due to non‐GHD causes like idiopathic short stature or like short stature in children born small for gestational age have suggested that GH treatment is associated with increased mortality or stroke.ObjectiveTo study the impact of GH replacement on overall and cause‐specific mortality in childhood‐onset GHD (CO GHD) patients.DesignA nationwide population‐based registry study on patients with CO GHD and general population controls matched on age and gender. Mortality hazard ratios (HRs) were computed comparing patients and controls, and comparing GH‐replaced patients and non‐GH‐replaced patients, using Cox regression. Comparing GH‐ and non‐GH‐replaced patients HRs were adjusted for birth year, year of diagnosis, gender, irradiation, ACTH insufficiency and primary disease.Patients and controlsA total of 494 patients with CO GHD each matched with 100 general population controls were included.ResultsMortality was substantially increased comparing patients with CO GHD and general population controls, HR = 7·51 (95% CI = 6·06–9·31). Comparing GH‐replaced patients with non‐GH‐replaced patients mortality was significantly decreased in total (HR = 0·27, CI = 0·17–0·43) and due to malignancy (HR = 0·14, CI = 0·07–0·28) in GH‐replaced patients. Adjusting for relevant confounders, this decrease remained significant both in total (HR = 0·56, CI = 0·32–0·96) and due to malignancy (HR = 0·33, CI = 0·16–0·69). Overall and cause‐specific mortality was increased in both GH‐replaced and non‐GH‐replaced patients compared to general population controls, but mortality was generally highest in non‐GH‐replaced patients.ConclusionThe present data from a national cohort of patients with CO GHD do not support the suggestion that GH replacement is associated with increased mortality.
Do Shareholder Coalitions Modify the Dominant Owner's Control? The Impact on Dividend Policy
Authors: López‐Iturriaga Félix J. , Santana‐Martín Domingo Javier 
Published: July 2015

AbstractManuscript TypeEmpiricalResearch QuestionWe examine the effect of shareholder coalitions on the corporate payout policy in Spain, a context characterized by the presence of dominant shareholders.Research FindingsOur results show that shareholder coalitions affect payout policy negatively (both for dividends and shares repurchases). We also find that the divergence between the voting rights involved in the coalition and the dominant owner's voting rights is negatively related to dividends.Theoretical/Academic ImplicationsOur findings suggest that shareholder coalitions can serve as an instrument for the dominant shareholders to extract private benefits. Our results also mean that the dominant owner uses the coalition as a mechanism to amplify his or her control over the firm and reduce the cost of expropriation.Practitioner/Policy ImplicationsRegulators should pay attention to the double role of shareholder agreements, as these coalitions could become an entrenchment mechanism for dominant shareholders. Our results highlight the importance of considering shareholder agreements when investors analyze the corporate dividend policy.