bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responsiveness and minimal important change of specific and generic patient-reported outcome measures for back patients: the Norwegian Neck and Back Register
Authors: Skatteboe Sigrid , Røe Cecilie , Heide Marte , Brox Jens Ivar , Ignatius Janica , Bratsberg Andrea , Wilhelmsen Maja , Bjørneboe John 
Published: July 2024

Abstract
Purpose
To evaluate responsiveness and minimal important change (MIC) of Oswestry Disability Index (ODI), pain during activity on a numeric rating scale (NRSa) and health related quality of life (EQ-5D) based on data from the Norwegian neck and back registry (NNRR).

Methods
A total of 1617 patients who responded to NNRR follow-up after both 6 and 12 months were included in this study. Responsiveness was calculated using standardized response mean and area under the receiver operating characteristic (ROC) curve. We calculated MIC with both an anchor-based and distribution-based method.

Results
The condition specific ODI had best responsiveness, the more generic NRSa and EQ-5D had lower responsiveness. We found that the MIC for ODI varied from 3.0 to 9.5, from 0.4 to 2.5 for NRSa while the EQ5D varied from 0.05 to 0.12 depending on the method for calculation.

Conclusion
In a register based back pain population, the condition specific ODI was more responsive to change than the more generic tools NRSa and EQ5D. The variations in responsiveness and MIC estimates also indicate that they should be regarded as indicative, rather than fixed estimates.
The short peptide encoded by long non-coding RNA RNF217-AS1 inhibits stomach cancer tumorigenesis, macrophage recruitment, and pro-inflammatory responses
Authors: Ma Qi , Ma Fei , Zhang Bin , Zhang Yonglei , Peng Liangqun , Li Xiangnan 
Published: July 2024

AbstractCertain long non-coding RNAs (lncRNAs) have potential peptide-coding abilities. Here, the role and molecular basis of the RNF217-AS1-encoded peptide in stomach cancer (SC) tumorigenesis were explored. Here, lncRNAs associated with SC pathogenesis and macrophage infiltration and lncRNAs with peptide-coding potential were searched by bioinformatics analysis. The gene mRNA and protein levels were examined by RT-qPCR and western blot assays, respectively. Cell viability, migratory, and invasive abilities were measured by CCK-8, Transwell migration, and Transwell invasion assays, respectively. The potential biological processes related to lncRNA RNF217-AS1 were identified by single-gene GSEA analysis. The effect of RNF217-AS1-encoded peptide on SC tumorigenesis was examined by mouse xenograft experiments. The results showed that lncRNA NR2F1-AS1 and RNF217-AS1 were differentially expressed and associated with macrophage infiltration in SC, and they had the ability to translate into short peptides. The RNF217-AS1 ORF-encoded peptide could reduce SC cell viability, inhibit cell migration and invasion, as well as hinder the development of SC xenograft tumors. The RNF217-AS1 ORF-encoded peptide in human SC AGS cells suppressed THP-1 cell migration, triggered the differential expression of CXCL1/CXCL2/CXCL8/CXCL12, and inactivated the TLR4/NF-κB/STAT1 signaling pathways. As a conclusion, the RNF217-AS1 ORF-encoded peptide hindered SC progression in vitro and in vivo and suppressed macrophage recruitment and pro-inflammatory responses in SC.
Home Treatment in der Kinder- und Jugendpsychiatrie in Niederösterreich
Authors: Zauner Johanna , Dörfler Sylvia , Schrank Beate , Mittmann Gloria , Dorczok Marie Celine , Neumann Matthias , Steiner-Hofbauer Verena 
Published: July 2024

ZusammenfassungAngesichts des globalen Anstiegs psychiatrischer Erkrankungen gewinnen Behandlungen im häuslichen Umfeld von Patient:innen (Home Treatments, HTs) in der psychiatrischen Versorgung zunehmend an Bedeutung. Die vorliegende Studie folgt einem thematischen Analyseansatz, um Daten aus Interviews mit acht Expert:innen zu analysieren, die im Rahmen von HTs der Kinder- und Jugendpsychiatrie des Universitätsklinikums Tulln, Niederösterreich, tätig sind. Ziel war es, ihre Erfahrungen und Ansichten zu HTs zu erfassen, mit einem speziellen Fokus auf die Evaluierung von HTs. Es wurde eine iterative Framework-Analyse angewendet, um Haupt- und Unterthemen zu identifizieren.Im Rahmen der Analyse der durchgeführten Interviews wurden insgesamt 88 Kodierungen ermittelt, die vier Hauptthemen umfassen: wichtige Aspekte, Anforderungen, Evaluation und mögliche Verbesserungen. HTs bieten eine niedrigschwellige und individuell zugeschnittene Behandlungs- bzw. Versorgungsmöglichkeit für junge Patient:innen mit starker Einbindung des sozialen Umfelds, welche ein tieferes Verständnis und eine engere Beziehung zu Gesundheitsfachkräften fördert. Anforderungen umfassen vorrangig den Wunsch nach Veränderung, realistische Zielsetzungen und Compliance der Patient:innen. Im Rahmen der Evaluation können diverse Ergebnisvariablen miteingeschlossen werden. Dabei sollen Einschätzungen verschiedener Evaluator:innen berücksichtigt und das Patient:innenumfeld miteinbezogen werden. Zukünftige Forschungen sollten sich auf die Evaluierung von HTs konzentrieren, um deren Einsatz und Angebote weiter zu fördern und auszubauen.
Clinical effects of teriparatide, abaloparatide, and romosozumab in postmenopausal osteoporosis
Authors: Ebina Kosuke , Etani Yuki , Noguchi Takaaki , Nakata Ken , Okada Seiji 
Published: July 2024

AbstractIn the management of osteoporosis, anti-resorptive agents serve as a primary therapeutic approach. However, in cases where individuals exhibit an increased susceptibility to fractures, such as those characterized by severe low bone mass or a history of vertebral or hip fractures that markedly diminish life expectancy, the immediate reduction of fracture risk through the administration of osteoanabolic agents could be beneficial. Teriparatide, available in daily, once-weekly, or twice-weekly dosages, along with abaloparatide and romosozumab, constitutes a trio of such agents. Each of these medications is defined by unique characteristics, distinct efficacy profiles, and specific adverse effects. There is growing evidence to suggest that these agents have a superior effect on enhancing bone mineral density and reducing fracture incidence when compared to traditional bisphosphonate therapies. Nonetheless, their employment demands thorough consideration of clinical indications, which includes evaluating economic factors, the frequency of injections required, and the potential for adverse effects. The objective of this review is to consolidate the current evidence focusing primarily on the efficacy of these agents, with the goal of enhancing understanding and aiding in making more informed treatment decisions, particularly for those individuals who are at an elevated risk of fractures.
Virtual reality exposure effect in acrophobia: psychological and physiological evidence from a single experimental session
Authors: Kristína Varšová , Dagmar Szitás , Oto Janoušek , Lenka Jurkovičová , Kateřina Bartošová , Vojtěch Juřík 
Published: July 2024

AbstractIn recent years, virtual reality (VR) has gained attention from researchers in diverse fields, particularly in therapy of phobias. Currently, virtual reality exposure therapy therapy (VRET) is considered a promising cognitive-behavioral therapy technique. However, specific psychological and physiological responses of VR users to virtual exposure in such a context are still only vaguely explored. In this experimental study, we mapped VR exposure in a height environment in people with a moderate fear of heights–acrophobia. Thirty-six participants were divided into experimental and control groups–with and without psychological guidance during exposure. Participants' subjective level of anxiety was examined, and objective physiological response was captured via heart rate variability (HRV) measurement. Psychological assessments recorded an anticipated rise in participant anxiety following exposure to height; nevertheless, no distinctions were observed in self-reported anxiety concerning psychological guidance. Notably, objective physiological measures revealed that VR exposure prompts physiological responses akin to real-world scenarios. Moreover, based on the analysis of heart rate variability, participants who received psychological guidance were identified as better at compensating for anxiety compared to those without such support. These findings support VRET as a promising tool for psychotherapy and advocate for psychological guidance as beneficial in reducing anxiety and managing stress during exposure. The results may help improve our understanding of anxiety during exposure to phobic stimuli.
Cognitive asymmetry in rats in response to emergent vs. disappearing affordances
Authors: Pisula Wojciech , Modlinska Klaudia , Chrzanowska Anna , Goncikowska Katarzyna 
Published: July 2024

Abstract
This study examines the effects of novel environmental changes on the behavior of rats in an experimental chamber. We hypothesized that newly discovered opportunities, detected by the animal’s cognitive system, would motivate greater investigation of environmental changes than comparable changes that prevent a given behavior. Three experiments differed in the emergence vs. elimination of affordances represented by open or closed tunnels. In Experiment 1, rats were habituated to a chamber with all four tunnels closed, and then two tunnels were opened. In Experiment 2, rats were habituated to a chamber where all four tunnels were open, and then two tunnels were closed. In Experiment 3, rats were habituated to a chamber with two open tunnels on one side, and two closed tunnels on the other. Then, the arrangement of open and closed tunnels was swapped. Results of the Exp. 1 show that the rats responded by spending more time near the newly opened tunnels and less time near the closed tunnels, the central zone, and the transporter. This suggests that rats are more motivated to investigate the environmental change combined with the emergent affordance (opening of the tunnels) than the environmental change alone. In Exp. 2, the rats responded by spending more time near the open tunnels and less time in the central zone. This suggests that the rats are more triggered by the available affordances (open tunnels) than by the environmental change (closed tunnels). Finally, in Exp. 3, the rats responded by spending more time near the newly opened tunnels and less near the central zone. However, they did not spend less time near the newly closed tunnels. These results suggest that rats process both the novelty itself and the emergence/disappearance of available affordances. The results are discussed regarding the cognitive asymmetry in the perception of emergent vs. disappearing affordances. It is proposed that the rat’s cognitive system is specialized for detecting newly emergent environmental opportunities/affordances rather than novelty in general.
Impact of acid and laser etching of enamel on microleakage in different adhesive systems
Authors: Atilan Yavuz Sevim , Erturk Avunduk Ayse Tugba , Karatas Ozcan , Çakır Kılınç Nazire Nurdan , Delikan Ebru 
Published: July 2024

Abstract
This study aimed to evaluate the microleakage of light-cured and self-cured adhesives on enamel surfaces selectively etched with Er, Cr: YSGG laser or 35% phosphoric acid. A total of 60 class V cavities were prepared 1 mm above the cemento-enamel junction (CEJ). The specimens were randomly divided into six groups. Group 1: Clearfil SE Bond with no conditioning, Group 2: Tokuyama Universal Bond with no conditioning, Group 3: Clearfil SE Bond conditioned with 35% phosphoric acid, Group 4: Tokuyama Universal Bond conditioned with 35% phosphoric acid, Group 5: Clearfil SE Bond conditioned with Er, Cr: YSGG laser and Group 6: Tokuyama Universal Bond conditioned with Er, Cr: YSGG laser. Microleakage was evaluated qualitatively (visually) and quantitatively (ImageJ). The data were analyzed using IBM SPSS V23 and submitted to Kruskal–Wallis and Wilcoxon tests. The significance level was set at p < 0.05. In all evaluation methods, the microleakage scores exhibit significant differences (p*<0.001). Group 1 and Group 3 exhibited similar and lower microleakage values than the Group 5. In the occlusal margin, the microleakage values were similar in Group 2, Group 4, and Group 6, whereas in the gingival margin Group 4 showed significantly lower leakage compared to Group 2. Regardless of the etching protocols and adhesive systems used, less microleakage was observed on the occlusal surface than on the gingival surface. Phosphoric acid etching provides better results than laser etching for enamel surface treatment on both occlusal and gingival surfaces.
Knowledge, attitudes, and practices of Japanese physicians relating to climate change impacts on health, delivery of climate-specific advice, and advocacy for climate change policies
Authors: Igarashi Niaya Harper , Suzuki Shu , Cahill Eri , Shimabukuro Akira , Sugawara Joji , Hashizume Masahiro 
Published: July 2024

Abstract
Aim
This study aimed to assess the knowledge, attitudes, and practices (KAP) of physicians in Japan toward climate change and health, their delivery of climate-specific advice to patients, and their advocacy for climate change policy.

Subject and methods
This cross-sectional study included licensed physicians active in clinical practice in Japan. Data were collected through a web-based platform from November 21 through November 27, 2023, using a 32-item self-administered questionnaire.

Results
A total of 1100 physicians with a mean age of 51.2 years (SD11.9) were included in the analysis. More than half (56.7%) agreed that physicians should advise their patients on the links climate change has on their health; however, less than half (32.6%) of the physicians responded that they do. Among the factors that reduced their action to deliver climate-specific health advice and advocacy were a lack of information/resources and knowledge. The multivariable logistic regression model showed that having prior climate change education or training, knowledge, and awareness is associated with physicians’ delivery of climate-specific advice to patients and advocating for climate change policy.

Conclusion
Many physicians recognize their responsibility to educate their patients on the impact climate change has on their health. There is a significant gap between the physicians’ willingness and what happens in practice. Among the main factors that reduce their action to engage in delivering climate-specific health advice and advocacy were a lack of information/resources and a lack of knowledge. Physicians need to be better equipped with the education, resources, and support to apply their expertise and influence to combat climate change.
SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients
Authors: Chen Can , Li Yun , Li Yiwei , Chen Zhenzhen , Shi Pengfei , Xie Yaping , Qian Shenxian 
Published: July 2024

AbstractCuprotosis related genes (CRGs) have been proved to be potential therapeutic targets for coronavirus disease 2019 (COVID-19) and cancer, but their immune and molecular mechanisms in COVID-19 infection in Diffuse Large B-cell Lymphoma (DLBC/DLBCL) patients are rarely reported. Our research goal is first to screen the key CRGs in COVID-19 through univariate analysis, machine learning and clinical samples. Secondly, we determined the expression and prognostic role of key CRGs in DLBCL through pan-cancer analysis. We validated the expression levels and prognosis using multiple datasets and independent clinical samples and validated the functional role of key CRGs in DLBCL through cell experiments. Finally, we validated the expression levels of CRGs in COVID-19 infected DLBCL patients samples and analyzed their common pathways in COVID-19 and DLBCL. The results show that synuclein-alpha (SNCA) is the common key differential gene of COVID-19 and DLBCL. DLBCL cells confirm that high expression of SNCA can significantly promote cell apoptosis and significantly inhibit the cycle progression of DLBCL. High expression of SNCA can regulate the binding of major histocompatibility complexes (MHCs) and T cell receptor (TCR) by regulating immune infiltration of Dendritic cells, effectively enhancing T cell-mediated anti-tumor immunity and clearing cancer cells. In conclusion, SNCA may be a potential therapeutic target for COVID-19 infection in DLBCL patients. Our study provides a theoretical basis for improving the clinical treatment of COVID-19 infection in DLBCL patients.
Needs, Experiences, and Hopes for Aging Futures among Older Adults in the LGBTQ Communities: A Qualitative Study in Israel
Authors: Sperling Daniel 
Published: July 2024

AbstractOlder lesbian, gay, bisexual, trans, and queer (LGBTQ) individuals tend to live alone, mostly without children and with scarce support from nuclear family members or biological kin. Moreover, traditional resources may not suit their specific end-of-life care needs. While studies have examined these topics in general, they lack focus on end-of-life needs, care, and planning in Israel. Moreover, research on this topic among members of LGBTQ communities is specifically lacking. This study, therefore, aimed at identifying and understanding the attitudes, perceptions, and meanings of older LGBTQ individuals in Israel regarding their needs and challenges, as they age and near end of life. The phenomenological qualitative research methodology was applied, following the interpretive approach. Twenty-one middle-aged and older LGBTQ individuals in Israel, aged ≥ 55, participated in the study. In-depth semi-structured interviews, conducted from November 2020 to April 2021, were audio-recorded, transcribed, and de-identified. Five themes emerged from the interviews: (1) Experiences of loneliness, marginalization, and trauma, and coping through liberation; (2) ageism and exclusion of older adults; (3) elastic and challenging relationships; (4) end of life as reverting into the closet and heteronormativity; and (5) death as a source of generativity and creativity. The study demonstrates that loneliness is an existential experience, exacerbated by the intersectionality of LGBTQ communities. In turn, chosen family members play a minimal role in the end-of-life care of their loved ones. While conveying ambivalence toward social services and housing for the aging, participants in this study expressed fear of being discriminated against and having to re-enter the closet as they age. Ageism and end of life do not represent finality and extinction, yet instead, signify hope and revival. Following Sandberg and Marshall’s (2017) concept of queering aging futures, this study refines our understanding of life courses, demonstrating that living and thriving in old age could be positive and desirable. As such, ageism and end of life do not necessarily represent finality and extinction, and may instead signify hope and revival. The unique challenges associated with family and social support of older adults who are LGBTQ members, and their implications on care, deserve further research and are important for practice.
The Treatment Needs and Experiences of Pedohebephiles: A Systematic Review
Authors: Chronos Agatha , Jahnke Sara , Blagden Nicholas 
Published: July 2024

AbstractPeople with a sexual interest in children face significant barriers to seeking and receiving mental health treatment. This review aims to bridge the gap between the treatment needs and experiences of pedohebephiles, and the services aiming to support them. Reviewers screened 1705 database hits and extracted findings from 22 qualitative, 15 quantitative, and 3 mixed-method studies on the treatment needs and experiences of pedohebephiles. Research suggests that this population experiences significant levels of distress, depression, and anxiety related to their sexual interest. Many individuals belonging to this population would seek (median = 42.3%), or have sought (median = 46.5%), treatment to cope with their sexual interest or with potential related mental health repercussions. Their experiences in treatment have been mixed, with some reporting positive experiences with empathic therapists and others reporting rejection. Most frequently, pedohebephiles report fear of exposure and rejection as barriers to seeking treatment, in addition to fear of the legal repercussions. The current study is the first to summarize and discuss previous findings on the treatment needs and experiences of pedohebephiles. The findings indicate that the treatment needs of pedohebephiles often remain unaddressed. Suggestions to increase the fit between treatment services and the needs of pedohebephiles are put forward.
Analysis of eigenvalue condition numbers for a class of randomized numerical methods for singular matrix pencils
Authors: Kressner Daniel , Plestenjak Bor 
Published: July 2024

AbstractThe numerical solution of the generalized eigenvalue problem for a singular matrix pencil is challenging due to the discontinuity of its eigenvalues. Classically, such problems are addressed by first extracting the regular part through the staircase form and then applying a standard solver, such as the QZ algorithm, to that regular part. Recently, several novel approaches have been proposed to transform the singular pencil into a regular pencil by relatively simple randomized modifications. In this work, we analyze three such methods by Hochstenbach, Mehl, and Plestenjak that modify, project, or augment the pencil using random matrices. All three methods rely on the normal rank and do not alter the finite eigenvalues of the original pencil. We show that the eigenvalue condition numbers of the transformed pencils are unlikely to be much larger than the $$\delta $$
δ
-weak eigenvalue condition numbers, introduced by Lotz and Noferini, of the original pencil. This not only indicates favorable numerical stability but also reconfirms that these condition numbers are a reliable criterion for detecting simple finite eigenvalues. We also provide evidence that, from a numerical stability perspective, the use of complex instead of real random matrices is preferable even for real singular matrix pencils and real eigenvalues. As a side result, we provide sharp left tail bounds for a product of two independent random variables distributed with the generalized beta distribution of the first kind or Kumaraswamy distribution.