bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibrinogen post‐translational modifications are biochemical determinants of fibrin clot properties and interactions
Authors: Tenopoulou Margarita 
Published: August 2024

The structure of fibrinogen and resulting fibrin formed during the coagulation process have important biological functions in human physiology and pathology. Fibrinogen post‐translational modifications (PTMs) increase the complexity of the protein structure and many studies have emphasized the potential associations of post‐translationally altered fibrinogen with the formation of a fibrin clot with a prothrombotic phenotype. However, the mechanisms by which PTMs exert their action on fibrinogen, and their causal association with disease pathogenesis are relatively unexplored. Moreover, the significance of fibrinogen PTMs in health has yet to be appreciated. In this review, the impact of fibrinogen PTMs on fibrinogen functionality is discussed from a biochemical perspective, emphasizing the potential mechanisms by which PTMs mediate the acquisition of altered fibrinogen properties. A brief discussion on dysfibrinogenemias of genetic origin, attributed to single point variations of the fibrinogen molecule is also provided, highlighting the influence that amino acid properties have on fibrinogen structure, properties, and molecular interactions that arise during thrombus formation.
‘DAS MÖRDERISCHE GESETZ DES LEBENS’: ABORTION, EUGENICS AND SOCIAL DARWINISM IN DOLOROSA'S UNFRUCHTBARKEIT (1905) AND DIE STARKEN (1907)
Authors: Borrmann Fatima 
Published: August 2024

ABSTRACTThis article deals with the literary contributions of the overlooked writer Dolorosa (a pseudonym for Maria Eichhorn), examining her work in conjunction with the eugenic and abortion debates prevalent in early twentieth‐century Germany. I analyse two of Dolorosa's novels, Unfruchtbarkeit (1905) and Die Starken (1907), and contextualise them within a broader artistic, cultural, and scientific milieu characterised by a pervasive emphasis on Social Darwinist principles of survival struggle. I also explore how the glorification of strength and competition was gendered during this period: men were often associated with attributes of power and conflict, while women were characterised by selfless and benevolent traits due to their maternal roles. In contrast to many feminists of her time who utilised eugenic ideals of motherhood to advocate for emancipation, Dolorosa diverges from the male‐dominated narrative surrounding survival struggle. Rather than reinforcing the legitimacy of the new ethics of the ‘right of the strong’, Dolorosa's portrayal of mothers grappling for survival prompts critical questioning of these emerging ideologies.
Evaluation of a Faith‐Placed Health Education Service on Bowel Cancer Screening in Mosques in East London
Authors: Waqar Salman , Yerrakalva Dharani , Duffy Thomas E. , Chambers Jake , Ali Zohra , Thomas Paul , Cook Caroline , Alam Sufia , Khagram Leena , Quaife Samantha , Duffy Stephen W. 
Published: August 2024

ABSTRACTBackgroundBowel cancer screening using faecal immunochemical testing is provided in the United Kingdom with the aim of reducing mortality from colorectal cancer. However, there are low participant rates among ethnic minorities across the United Kingdom. Faith‐placed interventions have the potential to improve screening rates among such populations, but studies examining their effectiveness are scarce.MethodsWe delivered a presentation on bowel cancer screening to 204 Muslims in seven mosques in East London (intervention group). All participants completed a questionnaire regarding attitudes, perceptions and knowledge of bowel cancer screening before and after the presentation. Concurrently, we administered the questionnaire to 72 subjects attending a mosque that did not receive the presentation (comparison group).ResultsThe intervention group showed a greater willingness to do the test (90% vs. 67%, p < 0.001) and to recommend it to others (96% vs. 74%, p < 0.001), ability to complete the test by themselves (94% vs. 56%, p < 0.001) and confidence in noticing symptoms (78% vs. 32%, p < 0.001) after the presentation compared to before. There was a significant difference between the intervention group post‐presentation and the comparison group on intention to do the test (90% vs. 79%, p = 0.02), recommending it to others (96% vs. 83%, p < 0.001), and confidence in their ability to complete the test by themselves (94% vs. 63%, p < 0.001).ConclusionA culture‐sensitive, faith‐placed health education intervention delivered in mosques can substantially improve knowledge of bowel cancer screening and increase the intention to participate in the screening programme.Patient or Public ContributionThe intervention presentation was developed using insights from four public involvement sessions with four to six members representative of the East London Muslim community. The sessions sought attendees’ thoughts on appropriate ways to approach the intervention design for their community and asked for their views on the acceptability, appropriateness of messaging, format/design and likely impact of the presentation. Their views were then utilised to improve the presentation.
Processing, microstructure, and mechanical properties of chopped SiC fibers reinforced ZrB2–hBN–based composites
Authors: Zou Ji , Zhao Guanlin , Liang Huayue , Liu Jingjing , Ji Wei , Wang Weimin , Fu Zhengyi 
Published: August 2024

AbstractThis study selected ZrB2–hBN ceramics as the matrix for low‐cost second‐generation SiC fibers, due to their low modulus and ability to be sintered at relatively low temperatures. The resulting composites, which contained up to 30 wt.% short‐chopped SiCf, were consolidated using reactive spark plasma sintering at 1550 and 1700°C under 50 MPa for 5 min. Without needing to prepare interfaces on the SiCf surfaces, fiber pullout, strengthening, and toughening during the fracture process were realized. By constructing the volatility phase diagram for the fiber, the microstructural changes that occurred on the fiber surfaces during sintering were successfully illustrated. Mechanical properties of ZrB2–hBN ceramics with 10 wt.% SiCf sintered at 1550°C still showed considerable improvements, including an elastic modulus of 187 GPa, a flexural strength of 337 ± 16 MPa, and a fracture toughness of 4.12 ± 0.25 MPa m1/2, increases of 12.6%, 61.2%, and 118%, respectively, compared to the counterparts without adding chopped fibers. Variations in these properties were linked to the matrix porosity and SiCf pullout behaviors, which were subsequently analyzed using the He–Hutchinson model.
A passage through India: The biotic ferry model supports the build‐up of Indo‐Australian biodiversity of an ancient soil arthropod clade
Authors: Manivannan Maya , Gurung Nehal , Edgecombe Gregory D. , Joshi Jahnavi 
Published: August 2024

AbstractAimScutigeromorpha is a globally distributed, ancient group of centipedes with at least 400 million years of evolutionary history. We assess the biogeographic history of the order, with a particular focus on the Peninsular Indian Plate (PIP), a Gondwanan fragment. We hypothesize that continental vicariance explains the disjunct distribution of extant scutigeromorphs, that PIP scutigeromorphs are of ancient Gondwanan origins, and that East Gondwana vicariance explains the diversification of the subfamily Thereuoneminae into its Asian and Australian clades.LocationGlobal.TaxaCentipedes, Scutigeromorpha.MethodsWe use a novel molecular dataset sampled across the PIP and a global sequence database representing the geographic distribution of all families and subfamilies. We employ molecular phylogenetic analyses on two mitochondrial and three nuclear markers, molecular species delimitation and ancestral range estimation to reconstruct biogeographic history.ResultsAncestral scutigeromorphs were likely widely distributed across Gondwana and diverged prior to any continental vicariance. Their subsequent biogeography is shaped by continental vicariance, long‐distance dispersal and jump dispersal, indicating an ability to colonize areas far from their ancestral range. The PIP emerged as the ancestral range of Thereuoneminae, which started diversifying during the Cretaceous Period. Subsequent in‐situ diversification within the PIP and dispersals into Asia, Australia and the Pacific Islands best explained the extant distribution of Thereuoneminae, more so than East Gondwana vicariance.Main ConclusionsThe in‐situ diversification of PIP species and their ancient divergence suggest they represent Gondwanan relicts in a landmass whose biota is primarily dispersal‐driven. A single dispersal event from the PIP generated most of the extant diversity in Australia, another Gondwanan fragment. Furthermore, the discovery of 11 putative species from the PIP and the Andaman Islands, five times more than was known, highlights the Wallacean and Linnean shortfalls in tropical Asia.
How well do connectivity tools agree over the full life cycle? A case study of Irish Sea plaice Pleuronectes platessaLinnaeus, 1758
Authors: Geffen Audrey J. , Nash Richard D. M. , Fox Clive J. 
Published: August 2024

AbstractAdult plaice in the Irish Sea have distinct traits that reflect the spawning locations that could suggest a number of different populations. However, do connectivity pathways support this concept? Different tools are directed at measuring exchange or connectivity between different life‐history stages, and the challenge is to integrate the signals to obtain full life‐cycle estimates. Collectively, the different methods reveal stable connectivity between known spawning and nursery grounds, with sufficient exchange to maintain a single population with weak genetic structure.
Veterans' use of inpatient and outpatient palliative care: The national landscape
Authors: Kaufman Brystana G. , Woolson Sandra , Stanwyck Catherine , Burns Madison , Dennis Paul , Ma Jessica , Feder Shelli , Thorpe Joshua M. , Hastings S. Nicole , Bekelman David B. , Van Houtven Courtney H. 
Published: August 2024

AbstractBackgroundPalliative care improves the quality of life for people with life‐limiting conditions, which are common among older adults. Despite the Veterans Health Administration (VA) outpatient palliative care expansion, most research has focused on inpatient palliative care. This study aimed to compare veteran characteristics and hospice use for palliative care users across care settings (inpatient vs. outpatient) and dose (number of palliative care encounters).MethodsThis national cohort included veterans with any VA palliative care encounters from 2014 through 2017. We used VA and Medicare administrative data (2010–2017) to describe veteran demographics, socioeconomic status, life‐limiting conditions, frailty, and palliative care utilization. Specialty palliative care encounters were identified using clinic stop codes (353, 351) and current procedural terminology codes (99241–99245).ResultsOf 120,249 unique veterans with specialty palliative care over 4 years, 67.8% had palliative care only in the inpatient setting (n = 81,523) and 32.2% had at least one palliative care encounter in the outpatient setting (n = 38,726), with or without an inpatient palliative care encounter. Outpatient versus inpatient palliative care users were more likely to have cancer and less likely to have high frailty, but sociodemographic factors including rurality and housing instability were similar. Duration of hospice use was similar between inpatient (median = 37 days; IQR = 11, 112) and outpatient (median = 44 days; IQR = 14, 118) palliative care users, and shorter among those with only one palliative care encounter (median = 18 days; IQR = 5, 64).ConclusionsThis national evaluation provides novel insights into the care setting and dose of VA specialty palliative care for veterans. Among veterans with palliative care use, one‐third received at least some palliative care in the outpatient care setting. Differences between veterans with inpatient and outpatient use motivate the need for further research to understand how care settings and number of palliative care encounters impact outcomes for veterans and older adults.
Commensal Attraction: Eating Together as a Social Tool
Authors: Neuman Nicklas 
Published: August 2024

AbstractSocial and human sciences have demonstrated again and again how commensality—the practice of eating together—has substantial implications, across time and place, for how social life is configured. Closely related phenomena have also been explored in biologically oriented sciences focused on human behavior. Yet, there is still little dialogue between these and the mainstream social science analysis of food and eating, despite their shared interests in the role played by food and eating in the organization of social life. The paper strengthens this dialogue and proposes that eating together be analyzed as a social tool: an innovation for the organization of complex behavior. More precisely, the proposition is that the habitual, routinized, and ritualized communal eating we see today developed into a social tool for exercising a diverse set of biologically evolved social traits. Through in‐depth analyses of food sharing, meal sharing, and feasting, I propose three distinct propositions of commensality as a social tool: social coordination of needs (mainly nutritional); social order and complex interaction (primarily conversations); and the symbolic display of stratified social relations. Understanding communal eating as a social tool thus opens up for a unified theory to explain seemingly disparate social phenomena, such as the underlying sociality displayed through different meal arrangements. For a thorough understanding of this, intensified conversations across the borders of scientific paradigms are required. Commensality is a social tool that satisfies both the social and biological appetites.
Performance of the IMMY® sona Aspergillus lateral flow assay for the detection of galactomannan in tracheal aspirate samples from Brazilian patients with COVID‐19‐associated pulmonary aspergillosis: Cross‐sectional and systematic review of literature
Authors: dos Santos Arthur Pereira , Amorim Bárbara Casella , da Silva Danielle Gomes , de Rodrigues Dality Keffelen Barros , da Costa Marques Ana Paula , Gasparoto Antonio Luiz Dal Bello , da Costa Alvarenga de Brito Eliana , Fava Wellington Santos , de Oliveira Caroline Tieppo Flores , Canassa Ana Luiza , Gonçalves Crhistinne Cavalheiro Maymone , Grande Antonio Jose , de Souza Carvalho Melhem Marcia , Paniago Anamaria Mello Miranda , Volpe‐Chaves Cláudia Elizabeth , Venturini James 
Published: August 2024

AbstractDuring the COVID‐19 pandemic, many patients in intensive care units (ICUs) were affected by invasive fungal infections, including aspergillosis, contributing to a high mortality rate. Diagnosing proven COVID‐19‐associated pulmonary aspergillosis (CAPA) requires clinical and radiological evaluations, along with laboratory testing of bronchoalveolar lavage samples or lung biopsies. However, these procedures and equipment are often inaccessible in developing countries or regions with limited resources, including Brazil. Consequently, alternative diagnostic methods, such as measuring Aspergillus galactomannan (GM) in tracheal aspirate (TA), have been explored for CAPA diagnosis. Nonetheless, research on the efficacy of TA‐based diagnostic tests is limited. This study aimed to assess the performance of the IMMY® Sona Aspergillus lateral flow assay (LFA) for GM detection in TA samples from 60 ICU patients with suspected CAPA at two tertiary hospitals in Campo Grande, Brazil. The ELISA method (Platelia Aspergillus AG, Bio‐Rad®) was used to detect Aspergillus GM in TA samples, serving as the microbiological criterion and reference test. Fifteen patients (12.4%) were identified as having possible CAPA. The overall accuracy of LFA was 94%, and the tests demonstrated an agreement of 93.1% (Cohen's kappa of 0.83). Based on our findings, the LFA for Aspergillus GM detection in TA samples exhibited excellent performance, proving to be a valuable diagnostic tool for potential CAPA. In a systematic review, two studies were included, and the meta‐analysis revealed pooled estimates provided a sensitivity of 86% (95% CI, 80%–91%) and specificity of 93% (95% CI, 86%–97%). The diagnostic odds ratio (DOR) for identification of Aspergillus using LFA was 103.38 (95% CI, 38.03–281.03). Despite its lower sensitivity compared to our study, the LFA appears to be a promising diagnostic option for CAPA, particularly in suspected cases that have not received antifungal therapy. This enables timely antifungal treatment and could reduce mortality rates in regions where bronchoscopy is unavailable or limited.
The transmembrane domain of the rice small protein OsS1Fa1 is responsible for subcellular localization and drought tolerance
Authors: Kwak J. S. , Lee K. H. , Min W. K. , Lee S. J. , Song J. T. , Seo H. S. 
Published: August 2024

Abstract

OsS1Fa1, a homologue of spinach S1Fa, is a small protein in rice that contains four distinct conserved motifs and participates in drought tolerance. However, the biological functions of these conserved motifs have not been characterized to date. Therefore, we investigated the roles of these conserved domains in the localization and cellular function of OsS1Fa1.
We analysed the subcellular localization of OsS1Fa1 using confocal laser scanning microscopy (CLSM), following particle bombardment and bacterial infiltration. An E. coli in vivo reconstituted sumoylation assay was conducted to investigate sumoylation of OsS1Fa1. We characterized the function of the transmembrane domain of OsS1Fa1 in drought tolerance using transgenic Arabidopsis plants.
Fluorescence analysis showed that OsS1Fa1 localized to the nuclear and cytoplasmic membranes. Mutation and cell fractionation analyses revealed that the membrane localization domain determined the subcellular localization of OsS1Fa1. The rice homologue OsS1Fa2 and Arabidopsis orthologs AtS1Fa1, AtS1Fa2, and AtS1Fa3 also exhibited similar localization patterns as OsS1Fa1. Sumoylation analysis demonstrated that OsS1Fa1 was conjugated with the small ubiquitin‐related modifier (SUMO). Transgenic analysis showed that overexpression of OsS1Fa1(TMm1), a mutant form of the transmembrane domain of OsS1Fa1, in Arabidopsis did not enhance drought stress tolerance, whereas OsS1Fa1 overexpression improved the drought tolerance of transgenic Arabidopsis.
Our data indicate that rice and Arabidopsis S1Fa1 proteins localize in the nuclear and cytoplasmic membranes, and that transmembrane domain determines subcellular localization and plays an important role in drought stress tolerance.
Sustainability risk management: Exploring the role of artificial intelligence capabilities through an information‐processing lens
Authors: Kong Kai Yuan , Yuen Kum Fai 
Published: August 2024

AbstractThe global sustainability movement is reshaping the operational requirements and managerial approaches of maritime firms, resulting in the emergence of unprecedented and complex risks in the sector. This has driven maritime firms to leverage digital tools, such as artificial intelligence (AI) capabilities, to enhance their sustainability risk management (SRM) endeavors. Drawing on the organizational information‐processing theory (OIPT), this study proposes four AI capabilities: customer value proposition, key process optimization, key resource optimization, and societal good. It examines their influence on sustainability‐related knowledge management capabilities (SKMC), stakeholder engagement, and SRM. A survey questionnaire was used to gather responses from 157 maritime professionals across various sectors of the industry, providing empirical data for analysis. Employing structural equation modeling, the findings reveal that AI capabilities can improve SKMC. These findings enhance existing literature by using OIPT concepts to investigate the interplay among the constructs that lead to better SRM in maritime firms. Furthermore, the study offers managerial guidance by providing insights into AI capabilities that maritime firms should incorporate into their operations, fostering best practices to effectively manage sustainability risks and ensure the firm's long‐term survival.
Shared sanitation facilities and risk of respiratory virus transmission in resource‐poor settings: A COVID‐19 modeling case study
Authors: Hayashi Michael A. L. , Simon Sophia M. , Zou Kaiyue , Van Wyk Hannah , Zahid Mondal Hasan , Eisenberg Joseph N. S. , Freeman Matthew C. 
Published: August 2024

AbstractWater supply and sanitation are essential household services frequently shared in resource‐poor settings. Shared sanitation can increase the risk of enteric pathogen transmission due to suboptimal cleanliness of facilities used by large numbers of individuals. It also can potentially increase the risk of respiratory disease transmission. As sanitation is an essential need, shared sanitation facilities may act as important respiratory pathogen transmission venues even with strict control measures such as stay‐at‐home recommendations in place. This analysis explores how behavioral and infrastructural conditions surrounding shared sanitation may individually and interactively influence respiratory pathogen transmission. We developed an individual‐based community transmission model using COVID‐19 as a motivating example parameterized from empirical literature to explore how transmission in shared latrines interacts with transmission at the community level. We explored mitigation strategies, including infrastructural and behavioral interventions. Our review of empirical literature confirms that shared sanitation venues in resource‐poor settings are relatively small with poor ventilation and high use patterns. In these contexts, shared sanitation facilities may act as strong drivers of respiratory disease transmission, especially in areas reliant on shared facilities. Decreasing dependence on shared latrines was most effective at attenuating sanitation‐associated transmission. Improvements to latrine ventilation and handwashing behavior were also able to decrease transmission. The type and order of interventions are important in successfully attenuating disease risk, with infrastructural and engineering controls being most effective when administered first, followed by behavioral controls after successful attenuation of sufficient alternate transmission routes. Beyond COVID‐19, our modeling framework can be extended to address water, sanitation, and hygiene measures targeted at a range of environmentally mediated infectious diseases.