bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of Validity for the Japanese Version of the Foot and Ankle Ability Measure
Authors: Uematsu Daisuke , Suzuki Hidetomo , Sasaki Shogo , Nagano Yasuharu , Shinozuka Nobuyuki , Sunagawa Norihiko , Fukubayashi Toru 
Published: October 2014

Context:
The Foot and Ankle Ability Measure (FAAM) is a valid, reliable, and self-reported outcome instrument for the foot and ankle region.

Objective:
To provide evidence for translation, cross-cultural adaptation, validity, and reliability of the Japanese version of the FAAM (FAAM-J).

Design:
Cross-sectional study.

Setting:
Collegiate athletic training/sports medicine clinical setting.

Patients or Other Participants:
Eighty-three collegiate athletes.

Main Outcome Measure(s):
All participants completed the Activities of Daily Living and Sports subscales of the FAAM-J and the Physical Functioning and Mental Health subscales of the Japanese version of the Short Form-36v2 (SF-36). Also, 19 participants (23%) whose conditions were expected to be stable completed another FAAM-J 2 to 6 days later for test-retest reliability. We analyzed the scores of those subscales for convergent and divergent validity, internal consistency, and test-retest reliability.

Results:
The Activities of Daily Living and Sports subscales of the FAAM-J had correlation coefficients of 0.86 and 0.75, respectively, with the Physical Functioning section of the SF-36 for convergent validity. For divergent validity, the correlation coefficients with Mental Health of the SF-36 were 0.29 and 0.27 for each subscale, respectively. Cronbach α for internal consistency was 0.99 for the Activities of Daily Living and 0.98 for the Sports subscale. A 95% confidence interval with a single measure was ±8.1 and ±14.0 points for each subscale. The test-retest reliability measures revealed intraclass correlation coefficient values of 0.87 for the Activities of Daily Living and 0.91 for the Sports subscales with minimal detectable changes of ±6.8 and ±13.7 for the respective subscales.

Conclusions:
The FAAM was successfully translated for a Japanese version, and the FAAM-J was adapted cross-culturally. Thus, the FAAM-J can be used as a self-reported outcome measure for Japanese-speaking individuals; however, the scores must be interpreted with caution, especially when applied to different populations and other types of injury than those included in this study.
Characterization of Human Anulus Fibrosus– and Nucleus Pulposus–Derived Cells During Monolayer Expansion and in Hydrogel Cultures
Authors: Schulze-Tanzil Gundula , Lemke Marion , Meier Carola , Ertel Wolfgang , Kohl Benjamin , Huang Zhao , Muschik Michael , Markart Markus , Hoyer Mariann , Arens Stephan 
Published: October 2014

In vitro-expanded intervertebral disc (IVD) cells could be a source for disc repair. However, IVD cell characterization still remains challenging and is demanded to detect phenotypical shifts. Therefore, the aim of the present study was to determine IVD cell expression profile during two- and three-dimensional culturing in direct comparison to in situ conditions. Human IVD tissue was analyzed immunohistologically and anulus fibrosus (AF) and nucleus pulposus (NP) cells were isolated and characterized for cytoskeletal architecture and expression of typical markers (type I, II, and III collagens, aggrecan, decorin, cartilage oligomeric protein, the chondrogenic transcription factor sox9, the tendon markers scleraxis and tenascin C) during 6 monolayer passages using real-time detection polymerase chain reaction and/or immunolabellings. Cells were introduced in alginate and collagen hydrogels and cell morphology and viablility was determined after 7 days. In addition to typical extracellular matrix components, IVD tissue and isolated cells revealed scleraxis expression. In early passages of cell expansion, genes of sox9, scleraxis, and the small proteoglycan decorin were expressed higher, but type I and III collagen genes were expressed lower in NP cells compared with AF cells. However, in passage 6, actin stress fibers increased and the expression levels of sox9 were nearly similar in NP and AF cells. The immunolabeling indicated that the fibroblast marker tenascin C could only be detected in vitro in both cell types but not in situ. Decorin protein expression decreased in both cell types in vitro in passage 6. IVD cells survived in both hydrogel cultures, and some cells elongated in collagen gels.
Hormonal Regulation of Calcium Signaling in Endocrine Cancers
Authors: George Nelson , Changtoo Megha , Singh Aru , Muthuswamy Srinivasan , Chakraborthy Bandana 
Published: October 2014

ABSTRACT
The calcium ion (Ca2+) plays a fundamental role in a number of physiological functions including bone formation, muscle contraction, secretion, enzyme cofactor, stabilization of membrane potentials, blood coagulation, etc. Calcium is homeostatically regulated by hormones that determines calcium balance within the body. The hormones PTH, 1,25-(OH)2D3 and calcitonin are altered in endocrine cancers which are in turn regulated by calcium. The main focus of this review is how hormones can regulate calcium homeostasis in endocrine cancers.

How to cite this article
George N, Changtoo M, Singh A, Kumar P, Muthuswamy S, Chakraborthy B. Hormonal Regulation of Calcium Signaling in Endocrine Cancers. World J Endoc Surg 2014;6(2):77-80.
A INVESTIGAÇÃO DOS CONHECIMENTOS PRÉVIOS SOBRE GEOMETRIA EUCLIDIANA, ESFÉRICA E HIPERBÓLICA POR MEIO DA UTILIZAÇÃO DE QUESTIONÁRIO
Authors: Brum Wanderley Pivatto , Schuhmacher Elcio 
Published: October 2014

A presente investigação consiste na identificação dos conhecimentos prévios sobre Geometria Euclidiana, Esférica e Hiperbólica, em estudantes da 2ª série do ensino médio de uma escola da rede pública de Tijucas, Santa Catarina. Para o reconhecimento das referidas concepções, foi utilizado um questionário semiestruturado, favorecendo a exposição de ideias por meio de textos e desenhos. O pensamento sobre aprendizagem significativa estudada por Ausubel e seus colaboradores foi o aporte teórico utilizado para reflexões e discussões a partir dos dados coletados. O estudo revelou diversas lacunas e fragilidades conceituais nas concepções dos estudantes sobre geometria.DOI: 10.5216/rir.v1i16.27228
De schadeclaim van het slachtoffer van strafbare feiten; bruggenbouwer tussen twee rechtsgebieden?
Authors: Ruitenbeek-Bart F.M. , Schijns A.J.J.G. 
Published: October 2014

De schadeclaim van het slachtoffer van strafbare feiten; bruggenbouwer tussen twee rechtsgebieden?
Zowel in het strafrecht als in het civiele letselschaderecht is (toenemende) aandacht voor de behoeften van slachtoffers. Bij beide categorieën slachtoffers leven zowel materiële als immateriële behoeften. Toch geven de beide disciplines op eigen wijze invulling aan deze behoeften. In deze bijdrage signaleren de auteurs overeenkomsten en verschillen in de benadering van het slachtoffer in het strafrecht en het civiele letselschaderecht en verkennen zij de mogelijkheden voor kruisbestuiving tussen de beide disciplines. Zij gaan onder andere in op de mogelijkheid om de civiele vordering van de benadeelde partij in het strafproces onder te brengen in een parallel civiel traject.
Bewijsvoering in de deelgeschilprocedure
Authors: Hogeling L.C. 
Published: October 2014

Bewijsvoering in de deelgeschilprocedure
De deelgeschilprocedure bestaat sinds juli 2010. De sindsdien verschenen jurisprudentie geeft een wisselend beeld van het toepassingsbereik. Regelmatig wordt een verzoek afgewezen omdat het zich volgens de rechter niet leent voor behandeling in een deelgeschilprocedure. In een deel van die gevallen ligt de oorzaak voor de afwijzing in het feit dat tijdens de behandeling van het deelgeschil is gebleken dat nadere bewijsvoering nodig is om daarover te kunnen beslissen. De deelgeschilprocedure biedt daartoe slechts beperkt ruimte. In deze bijdrage zal, op basis van de jurisprudentie, worden getracht aan te geven waar de grenzen liggen van de mogelijkheden tot bewijsvoering in een deelgeschilprocedure.
Hoger beroep in een deelgeschilprocedure, de einddatum van toekomstige schade en verhoging van het smartengeld vanwege in de literatuur bestaande discussie
Authors: Veendrick L.L. 
Published: October 2014

Hoger beroep in een deelgeschilprocedure, de einddatum van toekomstige schade en verhoging van het smartengeld vanwege in de literatuur bestaande discussie
Annotatie bij de uitspraken van het Gerechtshof Arnhem-Leeuwarden van 14 januari 2014 ( ECLI:NL:GHARL:2014:181, 183 en 185) over de einddatum van toekomstige schade en verhoging van het smartengeld vanwege in de literatuur bestaande discussie.
Beroepsziekten in Europa
Authors: Sorgdrager B. 
Published: October 2014

Beroepsziekten in Europa
Hoe de aanpak van beroepsziekten in Europa is geregeld, is onderwerp van een studie geweest in opdracht van de Europese Commissie. In deze bijdrage worden de conclusies van het rapport samengevat gepresenteerd, in het bijzonder de wijze waarop de diagnose beroepsziekte in Nederland wordt vastgesteld en voor het slachtoffer gewenste ontwikkelingen ten aanzien van de schadevergoeding.
Quantifying gravity wave momentum fluxes with Mesosphere Temperature Mappers and correlative instrumentation
Authors: Fritts David C. , Pautet P.‐Dominique , Bossert Katrina , Taylor Michael J. , Williams Bifford P. , Iimura Hiroyuki , Yuan Tao , Mitchell Nicholas J. , Stober Gunter 
Published: October 2014

AbstractAn Advanced Mesosphere Temperature Mapper and other instruments at the Arctic Lidar Observatory for Middle Atmosphere Research in Norway (69.3°N) and at Logan and Bear Lake Observatory in Utah (42°N) are used to demonstrate a new method for quantifying gravity wave (GW) pseudo‐momentum fluxes accompanying spatially and temporally localized GW packets. The method improves on previous airglow techniques by employing direct characterization of the GW temperature perturbations averaged over the OH airglow layer and correlative wind and temperature measurements to define the intrinsic GW properties with high confidence. These methods are applied to two events, each of which involves superpositions of GWs having various scales and character. In each case, small‐scale GWs were found to achieve transient, but very large, momentum fluxes with magnitudes varying from ~60 to 940 m2 s−2, which are ~1–2 decades larger than mean values. Quantification of the spatial and temporal variations of GW amplitudes and pseudo‐momentum fluxes may also enable assessments of the total pseudo‐momentum accompanying individual GW packets and of the potential for secondary GW generation that arises from GW localization. We expect that the use of this method will yield key insights into the statistical forcing of the mesosphere and lower thermosphere by GWs, the importance of infrequent large‐amplitude events, and their effects on GW spectral evolution with altitude.
Friedel–Crafts Reaction of Benzyl Fluorides: Selective Activation of CF Bonds as Enabled by Hydrogen Bonding
Authors: Champagne Pier Alexandre , Benhassine Yasmine , Desroches Justine , Paquin Jean‐François 
Published: October 2014

AbstractA Friedel–Crafts benzylation of arenes with benzyl fluorides has been developed. The reaction produces 1,1‐diaryl alkanes in good yield under mild conditions without the need for a transition metal or a strong Lewis acid. A mechanism involving activation of the CF bond through hydrogen bonding is proposed. This mode of activation enables the selective reaction of benzylic CF bonds in the presence of other benzylic leaving groups.
Total Synthesis of Hapalindole‐Type Natural Products
Authors: Lu Zhaohong , Yang Ming , Chen Pengxi , Xiong Xiaochun , Li Ang 
Published: October 2014

AbstractA unified and bioinspired oxidative cyclization strategy was used in the first total syntheses of naturally occurring 12‐epi‐hapalindole Q isonitrile, hapalonamide H, deschloro 12‐epi‐fischerindole I nitrile, and deschloro 12‐epi‐fischerindole W nitrile, as well as the structural revision of the latter. Hapalindoles H and Q were also synthesized.
Synthesis of Axially Chiral Biaryls through Sulfoxide‐Directed Asymmetric Mild CH Activation and Dynamic Kinetic Resolution
Authors: Hazra Chinmoy Kumar , Dherbassy Quentin , Wencel‐Delord Joanna , Colobert Françoise 
Published: October 2014

AbstractA mild and robust direct CH functionalization strategy has been applied to the synthesis of axially chiral biaryls. Such an efficient and stereoselective transformation occurs through an original dynamic kinetic resolution pathway enabling the conversion of diastereomeric mixtures of non‐prefunctionalized substrates into atropisomerically pure, highly substituted biaryl scaffolds. The main feature of this transformation is the use of an enantiopure sulfoxide as both chiral auxiliary and traceless directing group. The potential of newly synthesized biaryls as valuable building blocks is further illustrated.
Stereodivergent Total Synthesis of Δ9‐Tetrahydrocannabinols
Authors: Schafroth Michael A. , Zuccarello Giuseppe , Krautwald Simon , Sarlah David , Carreira Erick M. 
Published: October 2014

AbstractAll four stereoisomers of Δ9‐tetrahydrocannabinol (Δ9‐THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same set of starting materials, selective access to the four stereoisomers of THC was achieved in five steps.
Enantioselective Discrimination of Alcohols by Hydrogen Bonding: A SERS Study
Authors: Wang Yue , Yu Zhi , Ji Wei , Tanaka Yoshito , Sui Huimin , Zhao Bing , Ozaki Yukihiro 
Published: October 2014

AbstractEfficient and generic enantioselective discrimination of various chiral alcohols is achieved by using surface‐enhanced Raman scattering (SERS) spectroscopy through charge–transfer (CT) contributions. The relative intensities of the peaks in the SERS spectra of a chiral selector are strongly dependent on the chirality of its surroundings. This highly distinct spectral discrepancy may be due to the tendency of chiral isomers to form intermolecular hydrogen‐bonding complexes with the chiral selector in different molecular orientations, resulting in different CT states and SERS intensities of the adsorbates in the system. This study opens a new avenue leading to the development of novel enantiosensing strategies. A particular advantage of this approach is that it is label‐free and does not employ any chiral reagents, including chiral light.
Intramolecular Metalloamination of N,N‐Dimethylhydrazinoalkenes: A Versatile Method to Access Functionalized Piperidines and Pyrrolidines
Authors: Sunsdahl Bryce , Smith Adrian R. , Livinghouse Tom 
Published: October 2014

AbstractHighly diastereoselective metalloamination/cyclization reactions of zinc(II) hydrazides obtained through reaction of diethylzinc with N,N‐dimethylhydrazinoalkenes are described. The resulting organozinc intermediates undergo facile allylation and acylation, in situ, to provide the corresponding functionalized piperidines and pyrrolidines.
Synthesis of All Eight L‐Glycopyranosyl Donors Using CH Activation
Authors: Frihed Tobias Gylling , Pedersen Christian Marcus , Bols Mikael 
Published: October 2014

AbstractThe synthesis of all eight rare, but biologically important L‐hexoses as the according thioglycosyl donors was achieved through a procedure involving the CH activation of their corresponding 6‐deoxy‐L‐hexoses. The key steps of the procedure were the silylation of the OH group at C4 followed by an intramolecular CH activation of the methyl group in γ‐position; both steps were catalyzed by iridium. The following Fleming–Tamao oxidation and acetylation gave the suitably protected L‐hexoses. This is the first general method for the preparation of all eight L‐hexoses as their thioglycosyl donors ready for glycosylation and the first example of an iridium‐catalyzed C(sp3)H activation on sulfide‐containing compounds.
Fundamental Change in the Nature of Chemical Bonding by Isotopic Substitution
Authors: Fleming Donald G. , Manz Jörn , Sato Kazuma , Takayanagi Toshiyuki 
Published: October 2014

AbstractIsotope effects are important in the making and breaking of chemical bonds in chemical reactivity. Here we report on a new discovery, that isotopic substitution can fundamentally alter the nature of chemical bonding. This is established by systematic, rigorous quantum chemistry calculations of the isotopomers BrLBr, where L is an isotope of hydrogen. All the heavier isotopomers of BrHBr, BrDBr, BrTBr, and Br4HBr, the latter indicating the muonic He atom, the heaviest isotope of H, can only be stabilized as van der Waals bound states. In contrast, the lightest isotopomer, BrMuBr, with Mu the muonium atom, alone exhibits vibrational bonding, in accord with its possible observation in a recent experiment on the Mu+Br2 reaction. Accordingly, BrMuBr is stabilized at the saddle point of the potential energy surface due to a net decrease in vibrational zero point energy that overcompensates the increase in potential energy.
Increasing Hybridization Rate and Sensitivity of Bead‐Based Assays Using Isotachophoresis
Authors: Shintaku Hirofumi , Palko James W. , Sanders Glenn M. , Santiago Juan G. 
Published: October 2014

AbstractWe present an electrokinetic technique to increase the reaction rate and sensitivity of bead‐based assays. We use isotachophoresis (ITP) to preconcentrate and co‐focus target molecules and beads into a single ITP zone. The process achieves rapid mixing, stirring, and strongly increases the binding reaction rate. We demonstrate our assay with quantitative detection of 24 nt single‐stranded DNA over a dynamic range of three orders of magnitude and multiplexed detection of ten target species per sample. We show that ITP can achieve approximately the same sensitivity as a well‐stirred standard reaction in 60‐fold reduced reaction time (20 min versus 20 h). Alternately, compared to standard reaction times of 30 min, we show that 20 min ITP hybridization can achieve 5.3‐fold higher sensitivity.
Endothelial Cells Enhance the Migration of Bovine Meniscus Cells
Authors: Yuan Xiaoning , Eng George M. , Arkonac Derya E. , Chao Pen‐hsiu Grace , Vunjak‐Novakovic Gordana 
Published: October 2014

ObjectiveTo study the interactions between vascular endothelial cells and meniscal fibrochondrocytes from the inner avascular and outer vascular regions of the meniscus and to identify angiogenic factors that enhance cell migration and integrative repair.MethodsBovine meniscal fibrochondrocytes (bMFCs) from the inner and outer regions of meniscus were cultured for 7 days with or without human umbilical vein endothelial cells (HUVECs) in a micropatterned 3‐dimensional hydrogel system for assessment of cell migration. Angiogenic factors secreted by HUVECs were probed for their role in paracrine mechanisms governing bMFC migration and applied to a full‐thickness defect model of meniscal repair in explants from the inner and outer meniscal regions over 4 weeks.ResultsEndothelial cells enhanced the migration of inner and outer bMFCs in the micropatterned system via endothelin 1 (ET‐1) signaling. Supplementation with ET‐1 significantly enhanced the integration strength of full‐thickness defects in the inner and outer explants, as well as cell migration at the macroscale level, as compared to controls without ET‐1 treatment.ConclusionThis study is the first to show that bMFCs from both the avascular and vascular regions of the meniscus respond to the presence of endothelial cells with increased migration. Paracrine signaling by endothelial cells regulates the bMFCs differentially by region, but we identified ET‐1 as an angiogenic factor that stimulates the migration of inner and outer cells at the microscale level and the integrative repair of inner and outer explants at the macroscale level. These findings reveal the regional interactions between the vasculature and MFCs, and suggest ET‐1 as a potential new treatment for avascular meniscus injuries in order to prevent the development of osteoarthritis.
Association of Anti–Acidic Ribosomal Protein P0 and Anti–Galectin 3 Antibodies With the Development of Skin Lesions in Systemic Lupus Erythematosus
Authors: Shi Zhen‐rui , Tan Guo‐zhen , Meng Zhen , Yu Min , Li Kai‐wen , Yin Jing , Wei Kai‐hua , Luo Yi‐jin , Jia Shu‐qing , Zhang Shu‐juan , Wu Jian , Mi Xiang‐bin , Wang Liangchun 
Published: October 2014

ObjectiveThe specific autoantibodies and antigens that mediate systemic lupus erythematosus (SLE)–related organ injuries remain largely unknown. This study was undertaken to investigate the antibody‐mediated immune response that leads to SLE skin lesions.MethodsThe study included 85 SLE patients with lupus‐specific skin lesions and 31 without skin lesions. The reactivity of serum antibody with skin antigens was determined by immunoblotting using human foreskin as the substrate. Skin antigens were identified using mass spectrometry. Serum antibody was isolated by affinity purification and was injected intracutaneously into mouse skin to determine pathogenicity. Serum antibody levels were monitored by enzyme‐linked immunosorbent assay.ResultsWe determined that 78% of the patients with skin lesions had serum antibodies reactive with 35‐kd and/or 25‐kd skin antigens, which was significantly higher than the percentage of patients without skin lesions (P < 0.0001), suggesting a correlation between immune response and skin lesions. Acidic ribosomal protein P0 (RPLP0) and galectin 3 were 2 target antigens identified from 35‐kd and 25‐kd proteins, respectively. Purified serum anti‐RPLP0 and anti–galectin 3 antibodies induced lupus‐like histologic changes after intracutaneous injection. Anti‐RPLP0 and anti–galectin 3 antibody levels were significantly higher in SLE patients than in healthy controls and decreased with skin recovery. Anti–galectin 3 antibody levels were not significantly higher in SLE patients than in patients with dermatomyositis or scleroderma, but strongly related to lupus cutaneous vasculitis. Additionally, levels of the 2 antibodies were positively correlated with leukopenia and C3 deficiency, and the anti‐RPLP0 antibody level was also positively correlated with arthritis and SLE disease activity.ConclusionOur findings indicate that the immune response mediated by serum anti‐RPLP0 and anti–galectin 3 antibodies plays a key role in the pathogenesis of SLE skin lesions. These findings provide new insights into the mechanism of SLE‐related organ disorders.