bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic Resonance Imaging–Based Three‐Dimensional Bone Shape of the Knee Predicts Onset of Knee Osteoarthritis: Data From the Osteoarthritis Initiative
Authors: Neogi Tuhina , Bowes Michael A. , Niu Jingbo , De Souza Kevin M. , Vincent Graham R. , Goggins Joyce , Zhang Yuqing , Felson David T. 
Published: May 2013

ObjectiveTo examine whether magnetic resonance imaging (MRI)–based 3‐dimensional (3‐D) bone shape predicts the onset of radiographic knee osteoarthritis (OA).MethodsWe conducted a case–control study using data from the Osteoarthritis Initiative by identifying knees that developed incident tibiofemoral radiographic knee OA (case knees) during followup, and matching them each to 2 random control knees. Using knee MRIs, we performed active appearance modeling of the femur, tibia, and patella and linear discriminant analysis to identify vectors that best classified knees with OA versus those without OA. Vectors were scaled such that −1 and +1 represented the mean non‐OA and mean OA shapes, respectively. We examined the relation of 3‐D bone shape to incident OA (new‐onset Kellgren and Lawrence [K/L] grade ≥2) occurring 12 months later using conditional logistic regression.ResultsA total of 178 case knees (incident OA) were matched to 353 control knees. The whole joint (i.e., tibia, femur, and patella) 3‐D bone shape vector had the strongest magnitude of effect, with knees in the highest tertile having a 3.0 times higher likelihood of developing incident radiographic knee OA 12 months later compared with those in the lowest tertile (95% confidence interval [95% CI] 1.8–5.0, P < 0.0001). The associations were even stronger among knees that had completely normal radiographs before incidence (K/L grade of 0) (odds ratio 12.5 [95% CI 4.0–39.3]). Bone shape at baseline, often several years before incidence, predicted later OA.ConclusionMRI‐based 3‐D bone shape predicted the later onset of radiographic OA. Further study is warranted to determine whether such methods can detect treatment effects in trials and provide insight into the pathophysiology of OA development.
Assessment of the water supply to Mediterranean heavy precipitation: a method based on finely designed water budgets
Authors: Duffourg F. , Ducrocq V. 
Published: May 2013

AbstractA major ingredient for Mediterranean Heavy Precipitating Events (HPEs) is the low‐level moisture transport towards the coast. This paper proposes a methodology allowing a spatially and temporally continuous study of the water supply to Mediterranean HPEs. It is based on water budgets computed from mesoscale numerical simulation outputs. The method is applied on four typical HPEs over Southeastern France. It allows to identify and assess quantitatively the contributions of local Mediterranean and remote African and Atlantic moisture sources.
Diurnal cycle of precipitation over the eastern Indian Ocean off Sumatra Island during different phases of Indian Ocean Dipole
Authors: Fujita Mikiko , Takahashi Hiroshi G. , Hara Masayuki 
Published: May 2013

AbstractObserved difference in diurnal cycle of precipitation over the eastern Indian Ocean between positive and negative Indian Ocean Dipole (IOD) phases was investigated using a regional model. During the negative IOD phase, prominent precipitation peak was over the land during evening in both observation and model, while precipitation often appeared over the ocean during early morning. In the positive IOD phase, precipitation peak was shifted to the northern area where sea surface temperature was warm. The amount of precipitation in the southern area during the negative phase was more than three times larger than that in the positive phase.
Fluorescence quenching investigation on the interaction of glutathione‐CdTe/CdS quantum dots with sanguinarine and its analytical application
Authors: Shen Yizhong , Liu Shaopu , He Youqiu 
Published: May 2013

ABSTRACTWater‐soluble glutathione (GSH)‐capped core/shell CdTe/CdS quantum dots (QDs) were synthesized. In pH 5.4 sodium phosphate buffer medium, the interaction between GSH‐CdTe/CdS QDs and sanguinarine (SA) was investigated by spectroscopic methods, including fluorescence spectroscopy and ultraviolet‐visible absorption spectroscopy. Addition of SA to GSH‐CdTe/CdS QDs results in fluorescence quenching of GSH‐CdTe/CdS QDs. Quenching intensity was in proportion to the concentration of SA in a certain range. Investigation of the quenching mechanism, proved that the fluorescence quenching of GSH‐CdTe/CdS QDs by SA is a result of electron transfer. Based on the quenching of the fluorescence of GSH‐CdTe/CdS QDs by SA, a novel, simple, rapid and specific method for SA determination was proposed. The detection limit for SA was 3.4 ng/mL and the quantitative determination range was 0.2–40.0 µg/mL with a correlation coefficient of 0.9988. The method has been applied to the determination of SA in synthetic samples and fresh urine samples of healthy human with satisfactory results. Copyright © 2013 John Wiley & Sons, Ltd.
The effect of immune therapy on surgical site infection following Crohn's Disease resection
Authors: Serradori T , Germain A , Scherrer M L , Ayav C , Perez M , Romain B , Palot J P , Rohr S , Peyrin-Biroulet L , Bresler L 
Published: May 2013

Abstract

Background
Patients with Crohn's disease are increasingly receiving antitumour necrosis factor α (anti-TNF-α) therapy. Whether anti-TNF-α therapy increases the risk of postoperative infectious complications in Crohn's disease is a matter of debate.

Methods
This was a retrospective study of three referral centres. The charts of patients who underwent ileocaecal or ileocolonic resection for Crohn's disease between 2000 and 2011 were reviewed. The impact of baseline characteristics and Crohn's disease-related medications on the risk of postoperative intra-abdominal infectious complications was investigated by univariable and multivariable analysis.

Results
A total of 217 patients were included in the study. Median age at the time of surgery was 36·8 (range 15–78) years. A postoperative intra-abdominal infection occurred in 24 (11·1 per cent) of 217 patients. No deaths were reported. On univariable analysis, age less than 25 years (P = 0·023), steroid use (P = 0·017), anti-TNF-α therapy (P = 0·043) and anti-TNF-α treatment in combination with steroids (P = 0·004) were associated with an increased risk of postoperative intra-abdominal infectious complications. On multivariable analysis, only anti-TNF-α therapy in combination with steroids significantly increased this risk (odds ratio 8·03, 95 per cent confidence interval 1·93 to 33·43; P = 0·035).

Conclusion
Combined use of steroids and anti-TNF-α therapy was associated with an increased risk of postoperative intra-abdominal infectious complications.
Dendrimer‐Encapsulated Bimetallic Pt‐Ni Nanoparticles as Highly Efficient Catalysts for Hydrogen Generation from Chemical Hydrogen Storage Materials
Authors: Aranishi Kengo , Singh Ashish Kumar , Xu Qiang 
Published: May 2013

AbstractBimetallic Pt‐Ni dendrimer‐encapsulated nanoparticles (DENs) with different Pt/Ni ratios have been successfully synthesized through the co‐complexation of Pt2+ and Ni2+ cations to the internal tertiary amine of fourth‐generation hydroxyl‐terminated poly(amidoamine) dendrimers (G4‐OH) followed by coreduction by NaBH4 in aqueous solution. The catalytic activities for the decomposition of hydrous hydrazine and the hydrolysis of ammonia borane over the Pt‐Ni DENs have been studied in aqueous solution, and the Pt‐Ni DENs show high catalytic performances for these hydrogen‐generation reactions. TEM measurements reveal that the size‐controlled Pt‐Ni NPs, which have an average particle size of 1.1±0.3 nm, are encapsulated in the G4‐OH dendrimer.
Aptamer‐Based SERS Assay of ATP and Lysozyme by Using Primer Self‐Generation
Authors: Ye Sujuan , Xiao Jie , Guo Yuanyuan , Zhang Shusheng 
Published: May 2013

AbstractA simple bifunctional surface‐enhanced Raman scattering (SERS) assay based on primer self‐generation strand‐displacement polymerization (PS‐SDP) is developed to detect small molecules or proteins in parallel. Triphosphate (ATP) and lysozyme are used as the models of small molecules and proteins. Compared to traditional bifunctional methods, the method possesses some remarkable features as follows: 1) by virtue of the simple PS‐SDP reaction, a bifunctional aptamer assembly binding of trigger 1 and trigger 2 was used as a functional structure for the simultaneous sensing of ATP or lysozyme. 2) The concept of isothermal amplification bifunctional detection has been first introduced into SERS biosensing applications as a signal‐amplification tool. 3) The problem of high background induced by excess bio‐barcodes is circumvented by using magnetic beads (MBs) as the carrier of signal‐output products and massive of hairpin DNA binding with SERS active bio‐barcodes relied on Au nanoparticles (Au NPs), SERS signal is significantly enhanced. Overall, with multiple amplification steps and one magnetic‐separation procedure, this flexible biosensing system exhibited not only high sensitivity and specificity, with the detection limits of ATP and lysozyme of 0.05 nM and 10 fM, respectively.
Advanced simulation of transient multiphase flow & flow assurance in the oil & gas industry
Authors: Lakehal Djamel 
Published: May 2013

AbstractWe discuss here current computational trends (beyond Mechanistic 1D Models) related to transient multiphase flow and flow assurance problems in the oil and gas sector. The developments needed to bring advanced Computational fluid & Multiphase‐fluid dynamics (CFD & CMFD) techniques and models to a mature stage will also be discussed. The contribution presents the possibilities offered today by these simulation technologies to treat complex, multiphase, multicomponent flow problems occurring in the gas and petroleum engineering in general. Examples of various degrees of sophistication will be presented, without focusing on the validation aspect as such. The models are briefly introduced (phase averages, N‐phase, interface tracking, Lagrangian particle tracking and granular flow model). © 2013 Canadian Society for Chemical Engineering
Physician Factors Affecting Cardiac Rehabilitation Referral and Patient Enrollment: A Systematic Review
Authors: Ghisi Gabriela L. M. , Polyzotis Peter , Oh Paul , Pakosh Maureen , Grace Sherry L. 
Published: May 2013

AbstractPhysicians play an important role in CR referral and enrollment. Despite established benefits and recommendations, cardiac rehabilitation (CR) enrollment rates are pervasively low. The reasons cardiac patients are missing from CR programs are multifactorial and include provider factors. A number of studies have now investigated physician factors associated with referral to CR programs and patient enrollment. The objective of this study was to qualitatively and systematically review this literature. A literature search of MEDLINE, PsycINFO, CINAHL, Embase, and EBM was conducted for published articles from database inception to October 2011. Overall, 17 articles were included following a process of independent review of each article by 2 authors. Seven (41.2%) were graded as good quality according to Downs and Black criteria. There were no randomized controlled trials. Results showed that medical specialty (ie, cardiac specialists more likely to refer; n = 8 studies) and other physician‐reported reasons (eg, physician report of their reasons for CR referral and physician sex) were related to referral. Physician factors related to patient enrollment in CR were physician endorsement, medical specialty, being referred, and physician attitudes toward CR. Physician factors are consistently related to CR referral and enrollment. The role of physician endorsements in promoting patient enrollment should be optimized and exploited.
Discovery of Piperidine‐Linked Pyridine Analogues as Potent Non‐nucleoside HIV‐1 Reverse Transcriptase Inhibitors
Authors: Chen Xuwang , Li Yuanyuan , Ding Shufang , Balzarini Jan , Pannecouque Christophe , De Clercq Erik , Liu Huiqing , Liu Xinyong 
Published: May 2013

AbstractIn our continued efforts to discover more active and less toxic HIV‐1 non‐nucleoside reverse transcriptase inhibitors, we recently designed a novel series of piperidine‐linked pyridine analogues on the basis of diarylpyrimidine derivatives, among which two drugs—etravirine and rilpivirine—are approved for use by the US FDA. The title compounds were evaluated for activity against wild‐type and resistant mutant strains of HIV‐1 as well as HIV‐2 in MT‐4 cells. The highly potent compound BD‐c1 (EC50=10 nM, CC50≥146 μM, SI≥14 126) displays lower cytotoxicity and higher selectivity than etravirine (EC50=2.2 nM, CC50=28 μM, SI=12 884) against wild‐type HIV‐1. Compound BD‐e2 (EC50=5.1 nM) shows greater antiviral efficacy against wild‐type HIV‐1 than do the four reference drugs nevirapine, delavirdine, efavirenz, and zidovudine. Many compounds were also found to be active against the frequently observed drug‐resistant double mutant (K103N+Y181C) HIV‐1 strain. Herein we report the design, synthesis, anti‐HIV evaluation, preliminary structure–activity relationships, and molecular simulations of novel piperidine‐linked pyridine analogues.
Reconstruction of retrospective cardiac activity—numerical study in a single cell and in a linear strand
Authors: Zafrir Zohar , Zlochiver Sharon 
Published: May 2013

SUMMARYAlthough computational modeling of the prospective electrical activity in the cardiac tissue is well established and robust, the retrospective extrapolation of this activity has not been explored to date. Here, we establish an algorithm for the backward‐in‐time extrapolation of electrical activity from measurements taken in the present. Using minimal human cardiac kinetic models and a modified Newton–Raphson algorithm, we demonstrate the feasibility of past activity reconstruction in a single cell and in a linear strand. In a single cell, reconstruction of state variables' shape, the action potential morphology, and the time of stimulation was successful for up to 1300 ms poststimulation and for data with signal‐to‐noise ratio levels higher than 40 dB. For linear strands, the action potential morphology was reconstructed for 500 ms poststimulation, and the reconstructed conduction velocity remained unaffected for signal‐to‐noise ratio levels higher than 50 dB. Moreover, tissue restitution properties due to various pacing rates were successfully reconstructed by the backward‐in‐time algorithm. These preliminary results demonstrate that past cardiac activity may be reconstructed from measurements in the present. We envision that this methodology could be implemented in future clinical applications, for example to trace the location and timing of ectopic foci during ablation procedures. Copyright © 2013 John Wiley & Sons, Ltd.
Deposition and Characterization of Luminescent Eu(tta)3phen‐Doped Parylene‐Based Thin‐Film Materials
Authors: Maggioni Gianluigi , Campagnaro Antonio , Tonezzer Michele , Carturan Sara , Quaranta Alberto 
Published: May 2013

AbstractHerein, novel host–guest films produced by coarse vacuum cosublimation of the parylene C dimer and Eu(tta)3phen are prepared and studied. Eu(tta)3phen sublimation at different temperatures allows films with different concentrations of the Eu complex to be obtained. The films are characterized by Rutherford backscattering spectrometry (RBS), FTIR spectroscopy, X‐ray diffraction (XRD), atomic force microscopy (AFM), and UV/Vis absorption and emission spectroscopy. RBS, FTIR, and XRD reveal the incorporation of Eu(tta)3phen into the parylene matrix. AFM evidences the very flat film surface, which is particularly advantageous for optical applications. UV/Vis absorption and emission analyses confirm that the optical properties of Eu(tta)3phen are preserved in the deposited films. Fluorescence measurements evidence the occurrence of an energy‐transfer process between parylene and Eu(tta)3phen, and this results in an increase in the light emitted by the Eu complex that is as much as five times higher than that emitted by Eu(tta)3phen alone.
Liquid Phase Isobutane/2‐Butene Alkylation Promoted by Hydrogen Chloride Using Lewis Acidic Ionic Liquids
Authors: Pöhlmann Ferdinand , Schilder Lisa , Korth Wolfgang , Jess Andreas 
Published: May 2013

AbstractIn isobutane/2‐butene alkylation, chloroaluminate ionic liquid catalysts (CAIL) deactivate fast with time on stream with respect to activity and selectivity. Hence, the effect of anhydrous hydrogen chloride (HCl), which shows co‐catalytic behavior, was studied in a batch reactor and its effect on both parameters was investigated. The co‐catalyst leads to an increased reaction rate and improves the yield of trimethylpentanes, the primarily desired high‐octane compounds of alkylation. Moreover, already deactivated CAIL catalysts are reactivated by gaseous HCl. In addition saturation of the ionic liquid with HCl prior to the reaction effectively suppresses the deactivation of the CAIL catalyst. Thus, the solubility of hydrochloric acid is reported for both the CAIL (IL: [BMIM]Cl/AlCl3, x=0.64) and organic phase to gain a deeper understanding of the reaction system. Finally conjunct polymers dissolved in the ionic liquid were extracted to study their influence on deactivation.
Recognition of a Bromide Ion by the Protonated Form of 2‐(1H‐Imidazol‐2‐ylthio)‐3‐methylnaphthalene‐1,4‐dione
Authors: Jali Bigyan R. , Baruah Jubaraj B. 
Published: May 2013

AbstractThe interactions of various acids, such as hydrochloric, hydrobromic, nitric, perchloric, and tetrafluoroboric acids with 2‐(1H‐imidazole‐2‐ylthio)‐3‐methylnaphthalene‐1,4‐dione (L) enhance the intensity of the fluorescence emission of L. Exceptionally, the interaction of hydrogen bromide with L not only enhances the emission intensity, but also leads to a sharp characteristic emission at λ=480 nm (λex=350 nm), which is different from the other acids. Bromide‐ion recognition by protonated L is explained on the basis of a tautomeric equilibrium. The Stokes shifts were calculated for each case and they were dependent on the anions and, in general, were found at λ>100 nm. Fluorescence lifetimes were measured and it was shown that two independent paths operated for the emission processes in solutions of the salts of L. Various salts of L with the general composition [HL][X] (in which X=Cl− (1), Br− (2), NO3− (3), ClO4− (4), and BF4− (5)) are structurally characterized. The coordination environment of the corresponding anion in these salts in the solid state is guided by electrostatic N+H⋅⋅⋅O interactions.
Superhydrophobic Activated Carbon‐Coated Sponges for Separation and Absorption
Authors: Sun Hanxue , Li An , Zhu Zhaoqi , Liang Weidong , Zhao Xinhong , La Peiqing , Deng Weiqiao 
Published: May 2013

AbstractHighly porous activated carbon with a large surface area and pore volume was synthesized by KOH activation using commercially available activated carbon as a precursor. By modification with polydimethylsiloxane (PDMS), highly porous activated carbon showed superhydrophobicity with a water contact angle of 163.6°. The changes in wettability of PDMS‐ treated highly porous activated carbon were attributed to the deposition of a low‐surface‐energy silicon coating onto activated carbon (confirmed by X‐ray photoelectron spectroscopy), which had microporous characteristics (confirmed by XRD, SEM, and TEM analyses). Using an easy dip‐coating method, superhydrophobic activated carbon‐coated sponges were also fabricated; those exhibited excellent absorption selectivity for the removal of a wide range of organics and oils from water, and also recyclability, thus showing great potential as efficient absorbents for the large‐scale removal of organic contaminants or oil spills from water.
Biodegradable radiopaque iodinated poly(ester urethane)s containing poly(ε‐caprolactone) blocks: Synthesis, characterization, and biocompatibility
Authors: Sang Lin , Wei Zhiyong , Liu Keliang , Wang Xinhui , Song Kedong , Wang Hong , Qi Min 
Published: May 2013

AbstractBiodegradable radiopaque iodinated poly(ester‐urethane) (I‐PU), consisting of poly(ε‐caprolactone) (PCL) diol and iodinated bisphenol A (IBPA), has been successfully synthesized via a coupling reaction of PCL‐diisocyanate and IBPA with varying compositions. The IBPA with four iodine atoms per molecule was applied as a chain extender to endow the I‐PUs with intrinsic X‐ray visibility. The chemical structure and molecular weights of I‐PUs were characterized by Fourier transform infrared spectroscopy (FT‐IR), proton‐nuclear magnetic resonance, and gel permeation chromatography (GPC). The effects of IBPA on the physical properties of I‐PUs were systematically studied by means of differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and wide‐angle X‐ray diffraction (WAXD). The DSC results showed that the crystallization of PCL segments in I‐PUs was restrained with increasing amount of IBPA, which was also confirmed by WAXD. In the X‐radiography analysis, all the synthesized I‐PUs exhibited high radiopacity compared with an aluminum wedge of equivalent thickness. Enzymatic degradation tests showed that the incorporation of IBPA prolonged the degradation of I‐PUs and distinct mass loss and degradation happened in the third month. Basic cytocompatibility conducted using rat adipose‐derived cells proved that all the I‐PUs and their biodegradation products were nontoxic. The radiopaque I‐PUs is expected to possess a significant advantage over the traditional polymer counterparts in some related biomedical fields. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1121–1130, 2014.
Antioxidant Properties and UV Absorbance Pattern of Mycosporine‐Like Amino Acids Analogs Synthesized in an Environmentally Friendly Manner
Authors: Andreguetti Daniel , Stein Erika M. , Pereira Claudio M. P. , Pinto Ernani , Colepicolo Pio 
Published: May 2013

ABSTRACTIn current study, we report efficient and clean procedure for preparing mycosporine‐like amino acids (MMAs) analogs and evaluate their ultraviolet absorbance properties and antioxidant activities. The ultraviolet radiation absorbance patterns of the compounds were recorded and then used to define their molar absorptivities. The antioxidant activities were assessed using 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging and superoxide radical scavenging assays. Eight of nine compounds showed good activity against superoxide radicals, as only one of the analogs exhibited a measurable IC50 in the DPPH assay. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:305‐312, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21489
Novel basic ionic liquids from cyclic guanidines and amidines – new catalysts for transesterification of oleochemicals
Authors: Nowicki Janusz , Muszyński Marcin , Gryglewicz Stanisław 
Published: May 2013

AbstractBACKGROUNDAlkylguanidinium and alkylamidinium hydroxides have been developed as new basic ionic liquids for the first time from cyclic guanidine (TBD) and amidines (DBN, DBU). The method of preparation of [bmim]OH decribed in the literature was adopted for the synthesis of new ionic liquids. Synthesis was carried out using cyclohexane as the solvent for the synthesis of alkylguanidine and alkylamidine bromides. Anion metathesis was carried out over anionic resins in water as solvent. The structures of the new ionic liquids were confirmed by spectral analysis. The catalytic activity of the new ionic liquids was tested in transesterification of fatty acid methyl esters with trimethylolpropane, neopentyl glycol and 2‐ethylhexyl alcohol.RESULTSThe new ionic liquids have good thermal stability and can be applied for transesterification processes. The highest conversion of FAME (83%) was obtained for TMP ester of oleic acid and ionic liquid [TBD‐Bu]OH.CONCLUSIONAmong the ionic liquids derived from cyclic guanidine and amidine only ionic liquids obtained from TBD are good catalysts for transesterification of FAME and polyols. In comparision with [bmim]OH, catalytic activity of TBD ionic liquids was comparable in the synthesis of TMP ester but better in the synthesis of 2EH esters. © 2013 Society of Chemical Industry