bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatitis C risk score as a tool to identify individuals with HCV infection: a demonstration and cross-sectional epidemiological study in Egypt
Authors: El-Khoury Rayane , Chemaitelly Hiam , Alaama Ahmed S , Hermez Joumana G , Nagelkerke Nico , Abu-Raddad Laith J 
Published: July 2024

ObjectivesHepatitis C virus (HCV) infection poses a global health challenge. By the end of 2021, the WHO estimated that less than a quarter of global HCV infections had been diagnosed. There is a need for a public health tool that can facilitate the identification of people with HCV infection and link them to testing and treatment, and that can be customised for each country.MethodsWe derived and validated a risk score to identify people with HCV in Egypt and demonstrated its utility. Using data from the 2008 and 2014 Egypt Demographic and Health Surveys, two risk scores were constructed through multivariable logistic regression analysis. A range of diagnostic metrics was then calculated to evaluate the performance of these scores.ResultsThe 2008 and 2014 risk scores exhibited similar dependencies on sex, age and type of place of residence. Both risk scores demonstrated high and similar areas under the curve of 0.77 (95% CI: 0.76 to 0.78) and 0.78 (95% CI: 0.77 to 0.80), respectively. For the 2008 risk score, sensitivity was 73.7% (95% CI: 71.5% to 75.9%), specificity was 68.5% (95% CI: 67.5% to 69.4%), positive predictive value (PPV) was 27.8% (95% CI: 26.4% to 29.2%) and negative predictive value (NPV) was 94.1% (95% CI: 93.5% to 94.6%). For the 2014 risk score, sensitivity was 64.0% (95% CI: 61.5% to 66.6%), specificity was 78.2% (95% CI: 77.5% to 78.9%), PPV was 22.2% (95% CI: 20.9% to 23.5%) and NPV was 95.7% (95% CI: 95.4% to 96.1%). Each score was validated by applying it to a different survey database than the one used to derive it.ConclusionsImplementation of HCV risk scores is an effective strategy to identify carriers of HCV infection and to link them to testing and treatment at low cost to national programmes.
Unbalanced core detector (UCD): a novel direct-reading dosimeter for FLASH radiotherapy
Authors: Bedogni R. , Russo L. , Calamida A. , Castro-Campoy A. I. , Fontanilla A. , Dashdondog D. , Caballero-Pacheco M. A. , Napolitano T. , Cantone C. , Pietropaolo A. , Felici G. 
Published: July 2024

AbstractFLASH radiotherapy (FRT) is a novel radiotherapy technique based on dose rates that are several orders of magnitude greater than those used in conventional radiotherapy (40 Gy/s vs. 0.5–5 Gy/min). FRT is still in its preclinical and early clinical stage of development. However these studies indicate that FRT is more effective in sparing normal tissues from radiation-related side effects, as compared to conventional radiotherapy. This is the so-called "FLASH effect" and was observed with multi-MeV electron beams. Before FRT is made available to humans, more basic research is needed to fully understand its radiobiology fundamentals. Meanwhile, suitable radiation sources and dosimetric tools are gradually becoming available. Within this framework, INFN-LNF developed the Unbalanced Core Detector (UCD), a novel type of electron dosimeter designed to operate in the FRT domain. UCD main characteristics are the nearly isotropic response, the independence from the electron energy, the very high radiation resistance, the linearity up to dose rates of MGy/s and the possibility to record the time evolution of a single radiation pulse. UCD was tested using 7 and 9 MeV electron beams produced with the ElectronFlash accelerator from Sordina IORT Technologies (SIT S.p.A.) in Aprilia, Italy. UCD was used to measure dose distributions in a water phantom. The results well compare to those obtained with a flashDiamond detector from PTW.
Apalutamide and Goserelin for Androgen Receptor–Positive Salivary Gland Carcinoma: A Phase II Nonrandomized Clinical Trial, YATAGARASU
Authors: Honma Yoshitaka , Monden Nobuya , Yamazaki Keisuke , Kano Satoshi , Satake Hironaga , Kadowaki Shigenori , Utsumi Yoshitaka , Nakatogawa Tomohiko , Takano Ryo , Fujii Koji , Koroki Yosuke , Aoyama Junya , Ouchi Shohei , Ogawa Tetsuro , McCarthy Sharon , Brookman-May Sabine D. , Mundle Suneel , Li Jinhui , Thaper Daksh , Nagao Toshitaka , Tada Yuichiro 
Published: June 2024

Abstract

Purpose:
To assess the efficacy and safety of apalutamide plus goserelin for androgen receptor (AR)–positive unresectable or recurrent/metastatic salivary gland carcinoma.

Patients and Methods:
This trial was an open-label, single-arm, multicenter phase II study. Patients with histologically confirmed unresectable or recurrent/metastatic salivary gland carcinoma with AR expression were included. The primary endpoint was the overall response rate (ORR) according to RECIST v1.1 by an independent central radiology review in the first 24 response-evaluable (RE) patients who had been observed at least 24 weeks from study initiation (primary RE patients). The efficacy was to be declared when at least 8 of the 24 primary RE patients responded.

Results:
A total of 31 patients were enrolled. In the first 24 primary RE patients with a median follow-up of 7.4 months, confirmed ORR by independent central radiology review was 25.0% [6/24 patients; 95% confidence interval, 9.8%–46.7%; P = 0.11 (one-sided)], which did not meet the predefined criteria of efficacy. Clinical benefit rate (ORR + rate of stable disease for at least 24 weeks) and median progression-free survival were 50.0% and 7.4 months, respectively. Both median duration of response and overall survival were not reached. Exploratory analyses showed a better ORR of 54.5% (6/11) in patients with AR positivity ≥70% and no history of prior systemic therapy. Grade 3 or higher treatment-emergent adverse events were reported in 35.5% (11/31), which included skin rash, anemia, leukopenia, and cancer pain.

Conclusions:
Although this study did not meet the predefined efficacy criteria, apalutamide plus goserelin showed clinically meaningful efficacy in a subset of patients with AR-positive salivary gland carcinoma and safety consistent with prior experience in prostate cancer.
Precision Targeting of the Gut Microbiome for Cancer Immunotherapy
Authors: Lombardi Pasquale , Pinato David J. 
Published: July 2024

Summary:Transforming gut microbial status from a prognostic trait to a therapeutic target is a key goal to understand and reverse resistance to anticancer immunotherapy. Glitza and colleagues propose selective manipulation of the gut microbiome with SER401 following antibiotic preconditioning and highlight multiple challenges in delivering microbiome manipulation to the clinic.See related article by Glitza et al., p. 1161 (8)
Invasive Assessment of Coronary Artery Disease in Clonal Hematopoiesis of Indeterminate Potential
Authors: Heimlich J. Brett , Raddatz Michael A. , Wells John , Vlasschaert Caitlyn , Olson Sydney , Threadcraft Marcus , Foster Kristoff , Boateng Emmanuel , Umbarger Kelsey , Su Yan Ru , Roden Dan M. , Barker Colin M. , Bick Alexander G. 
Published: June 2024

BACKGROUND:
Clonal hematopoiesis of indeterminate potential (CHIP) occurs due to acquired mutations in bone marrow progenitor cells. CHIP confers a 2-fold risk of atherosclerotic cardiovascular disease. However, there are limited data regarding specific cardiovascular phenotypes. The purpose of this study was to define the coronary artery disease phenotype of the CHIP population-based on coronary angiography.

METHODS:
We recruited 1142 patients from the Vanderbilt University Medical Center cardiac catheterization laboratory and performed DNA sequencing to determine CHIP status. Multivariable logistic regression models and proportional odds models were used to assess the association between CHIP status and angiography phenotypes.

RESULTS:

We found that 18.4% of patients undergoing coronary angiography had a CHIP mutation. Those with CHIP had a higher risk of having obstructive left main (odds ratio, 2.44 [95% CI, 1.40–4.27];
P
=0.0018) and left anterior descending (odds ratio, 1.59 [1.12–2.24];
P
=0.0092) coronary artery disease compared with non-CHIP carriers. We additionally found that a specific CHIP mutation, ten eleven translocase 2
(TET2
), has a larger effect size on left main stenosis compared with other CHIP mutations.

CONCLUSIONS:

This is the first invasive assessment of coronary artery disease in CHIP and offers a description of a specific atherosclerotic phenotype in CHIP wherein there is an increased risk of obstructive left main and left anterior descending artery stenosis, especially among
TET2
mutation carriers. This serves as a basis for understanding enhanced morbidity and mortality in CHIP.
Radiology reporting in rectal cancer using magnetic resonance imaging: Comparison of reporting completeness between different reporting styles and structure
Authors: Alvfeldt Gustav , Aspelin Peter , Blomqvist Lennart , Sellberg Nina 
Published: July 2024

Background The radiology report is vital for providing imaging information to guide patient treatment, and template-based reporting can potentially increase the reporting completeness. In 2014, a national reporting template for radiological staging of rectal cancer using magnetic resonance imaging (MRI) was implemented in Sweden. Purpose To evaluate the impact of the national reporting template by comparing and analysing differences in content and completeness in MRI reports between 2010 and 2016. Focus was to compare reporting completeness (i) between different reporting years and (ii) between three defined reporting styles. Material and Methods 493 MRI reports were gathered from 10 hospitals in four healthcare regions in Sweden, comprising 243 reports from 2010 and 250 reports from 2016. Reports were classified into three reporting styles: Expanded structured, Minimised structured, and Unstructured, and analysed using qualitative content analysis based on the national template. Results In 2010, all reports adhered to Unstructured reporting. In 2016, 44, 42, and 164 reports were conformant to Expanded structured, Minimised structured, and Unstructured reporting, respectively. A comparison between the years revealed a reporting completeness of 48% for 2010 reports and 72% for 2016 reports. Among the 2016 reporting styles, Unstructured reporting had the largest gap compared to the national template, with completeness at 64% versus 77.5% for Minimised structured reporting and 93% for Expanded structured reporting. Conclusion Implementation of template-based reporting according to Expanded structure is key to conform to national decided evidence-based practice for radiological staging of rectal cancer.
Early detection of breast cancer through the diagnosis of Nipple Aspirate Fluid (NAF)
Authors: Pant Abhishek , Anjankar Ashish. P. , Shende Sandesh , Dhok Archana , Jha Roshan Kumar , Manglaram Anjali Vagga 
Published: June 2024

AbstractThe development of breast cancer has been mainly reported in women who have reached the post-menopausal stage; therefore, it is the primary factor responsible for death amongst postmenopausal women. However, if treated on time it has shown a survival rate of 20 years in about two-thirds of women. Cases of breast cancer have also been reported in younger women and the leading cause in them is their lifestyle pattern or they may be carriers of high penetrance mutated genes. Premenopausal women who have breast cancer have been diagnosed with aggressive build-up of tumors and are therefore at more risk of loss of life. Mammography is an effective way to test for breast cancer in women after menopause but is not so effective for premenopausal women or younger females. Imaging techniques like contrast-enhanced MRI can up to some extent indicate the presence of a tumor but it cannot adequately differentiate between benign and malignant tumors. Although the ‘omics’ strategies continuing for the last 20 years have been helpful at the molecular level in enabling the characteristics and proper understanding of such tumors over long-term longitudinal monitoring. Classification, diagnosis, and prediction of the outcomes have been made through tissue and serum biomarkers but these also fail to diagnose the disease at an early stage. Considerably there is no adequate detection technique present globally that can help early detection and provide adequate specificity, safety, sensitivity, and convenience for the younger and premenopausal women, thereby it becomes necessary to take early measures and build efficient tools and techniques for the same. Through biopsies of nipple aspirate fluid (NAF) biomarker profiling can be performed. It is a naturally secreted fluid from the cells of epithelium found in the breast. Nowadays, home-based liquid biopsy collection kits are also available through which a routine check on breast health can be performed with the help of NAF. Herein, we will review the biomarker screening liquid biopsy, and the new emerging technologies for the examination of cancer at an early stage, especially in premenopausal women.
A rare cause of abdominal pain in pregnancy - mesenteric artery thrombosis and miscarriage in a 34-year-old patient
Authors: Melicher Dóra , Gaál Szabolcs , Berényi Tamás , Fenyves Bánk Gábor , Nagy Norbert , Hegedűs Péter , Fülöp András , Szijártó Attila , Varga Csaba 
Published: June 2024

Abstract
Background
Mesenteric arterial thrombosis is an extremely rare thrombotic event, especially during pregnancy, that can cause rapid fatal consequences unless the patient receives early definitive treatment.

Case presentation
We report the case of a 34-year-old female presenting in her seventh week of gestation with severe abdominal pain who was promptly diagnosed with mesenteric artery occlusion amidst incipient miscarriage. The patient underwent a successful mesentery artery embolectomy, recovered and was later diagnosed with elevated factor VIII activity.

Conclusion
The diagnosis of mesenteric ischemia should be considered in pregnant women presenting with severe abdominal pain and any prior predisposing factors. Our case highlights the pivotal role of the emergency physician in maintaining a high index of suspicion coupled with timely and determined action. The prognosis of this high mortality condition depends on prompt diagnosis, early definite management and successful multidisciplinary cooperation.
Stigma and its associations with self-confidence and sexual relations in 4 types of premature ejaculation
Authors: Liu Jishuang , Bao Tong , Wang Qunfeng , Jiang Hui , Zhang Xiansheng 
Published: July 2024

Abstract
Background
Although men with premature ejaculation (PE) always show more negative emotions, including embarrassment, guilt and worry, this may be related to the stigma of PE. To investigated stigma and its associations with self-confidence and sexual relations in 4 PE syndromes, a survey was conducted in our hospital from December 2018 to December 2019 among 350 men with self-reported PE and 252 men without self-reported PE. The stigma, self-confidence and sexual relations were assessed by the Social Impact Scale (SIS) and Self-Esteem and Relationship questionnaire (SEAR), respectively. Ejaculation control, sexual life satisfaction and distress caused by PE were evaluated by the Index of PE.

Results
Men with self-reported PE had higher internalized shame and social isolation scores and lower SEAR scores than control subjects. The highest score of internalized shame and social isolation and the lowest score of SEAR appeared in men with lifelong PE (LPE). After age adjustment, the positive relationships were stronger between distress about PE and internalized shame. Whereas, the stronger negative associations were found between social isolation and sexual satisfaction. The strongest association was observed between social isolation and sexual relationship. Therefore, the stigma associated with PE adversely affects the self-confidence, self-esteem, and sexual relationships of men with PE.

Conclusion
Men with PE, especially LPE, have a high level of stigma and disharmonious sexual relations, and often lack self-confidence and self-esteem, which have a certain negative impact on their physical and mental health and life. These will be the key issues to be considered when we formulate a personalized treatment plan for PE.
Echocardiography of persistent fifth aortic arch confirmed by computed tomography angiography or surgery in children: a case series
Authors: Yuan Rui , Li Hezhou , Wu Juan , Yin Xing 
Published: June 2024

Abstract
Background
The purpose of this study was to review echocardiography-based diagnosis of persistent fifth aortic arch (PFAA) in children.

Methods
From January 2015 to December 2022, we retrospectively analyzed the echocardiographic findings and the relevant clinical data during follow-up of patients with PFAA who were treated in the Third Affiliated Hospital of Zhengzhou University. The diagnosis was confirmed by computed tomography angiography or surgery.

Results
Seven PFAA cases included two Weinberg type A and five Weinberg type B. The anatomical details of PFAA were assessed using a combination of the long-axis view of the left ventricular outflow tract (from the left high parasternal window) and the long-axis view of the aortic arch (from the suprasternal window). In Weinberg type A, the distal fifth and fourth aortic arches were connected to the descending aorta, which was associated with aortic coarctation. In Weinberg type B, the upper arch of the fourth aorta was interrupted, and only the lower arch of the fifth aorta was connected to the descending aorta. Surgical repair of PFAA was indicated in five patients with blood flow disruption, among which four had good postoperative results and one refused surgery. Two patients with unobstructed PFAA blood flow required follow-up rather than surgery.

Conclusions
It is feasible to diagnose PFAA by echocardiography. Combined application of the high parasternal left ventricular outflow tract view and the suprasternal aortic arch view can improve timely detection of different types of PFAA in children.
Factors associated with a history of critical wandering among Medic-Alert subscribers
Authors: Cruz Antonio Miguel , Perez Hector , Rutledge Emily , Daum Christine , Liu Lili 
Published: June 2024

Abstract
Background
Critical wandering occurs when an individual living with dementia leaves a location and is unaware of place or time. Critical wandering incidents are expected to increase with the growing prevalence of persons living with dementia worldwide. We investigated the association between demographic, psychopathological, and environmental factors and a history of critical wandering among Medic-Alert subscribers, both with and without dementia.

Methods
Our retrospective study included data of 25,785 Canadian Medic-Alert subscribers who were aged 40 years or older. We used multivariable logistic regression analysis to examine the associations between a history of critical wandering and dementia status as psychopathological independent variable, controlled by demographic (age, ethnic background, sex at birth, Canadian languages spoken) and environmental (living arrangement, population density) factors.

Results
The overall study sample comprised of mainly older adults (77.4%). Medic-Alert subscribers who were older, male sex at birth, living with dementia, of a minority ethnic group and who did not have proficiency in an official Canadian language had a higher likelihood of a history of critical wandering. Residing in an urban environment, in an institution or with a family member, were environmental factors associated with a higher likelihood of a history of critical wandering.

Conclusions
People living with dementia experience a higher likelihood of a history of critical wandering compared to those without dementia. Medic-Alert and similar organizations can develop algorithms based on the associated factors that can be used to flag risks of critical wandering. This can inform preventative strategies at the individual and community levels.
Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/ tropical spastic paraparesis
Authors: Gois Luana Leandro , Ribeiro-Soares Bárbara , Regis-Silva Carlos Gustavo , Zanette Dalila L , Lisboa Raphaella , Nascimento Regina Santos , Coutinho Junior Raimundo , Galvão-Castro Bernardo , Grassi Maria Fernanda Rios 
Published: June 2024

Abstract
Background
Human T-cell lymphotropic virus type 1 (HTLV-1), also denominated Human T-cell leukemia virus-1, induces immune activation and secretion of proinflammatory cytokines, especially in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Regulatory T lymphocytes (Tregs) may control of inflammation through the production of regulatory cytokines, including IL10 and TGF-β. In this study we determined the frequencies of CD4 + and CD8 + Tregs in a HAM/TSP population, compared to asymptomatic carriers and uninfected individuals, as well as investigated the profiles of regulatory and inflammatory cytokines.

Methods
Asymptomatic HTLV-1 carriers and HAM/TSP patients were matched by sex and age. The frequencies of IL10- and/or TGF-β-producing Tregs were quantified by flow cytometry. Real-time reverse transcription polymerase chain reaction (RT-PCR) was used to quantify HTLV-1 proviral load and the mRNA expression of cytokines and cellular receptors in peripheral blood mononuclear cells.

Results
Total frequencies of CD4 + Tregs, as well as the IL10-producing CD4 + and CD8 + Treg subsets, were statistically higher in patients with HAM/TSP compared to asymptomatic HTLV-1-infected individuals. In addition, a positive correlation was found between the frequency of CD4 + IL10 + Tregs and proviral load in the HAM/TSP patients evaluated. A positive correlation was also observed between gene expression of proinflammatory versus regulatory cytokines only in HAM / TSP group.

Conclusions
A higher frequencies of IL10-producing Tregs were identified in patients with HAM/TSP. Imbalanced production of IL10 in relation to TGF-β may contribute to the increased inflammatory response characteristically seen in HAM/TSP patients.
Crohn’s disease in hemophilic arthropathy patient: a case report
Authors: Zhang Zhongyi , Chen Lei , Zhou Haojing , Chen Guoqian , Tong Peijian 
Published: June 2024

AbstractCrohn’s disease (CD) is an inflammatory bowel disease affecting the digestive tract, the incidence of which is on the rise worldwide. The most common clinical manifestation of hemophilia is arthropathy secondary to recurrent joint effusions and chronic synovitis. This article reports on a rare 25-year-old male patient with both hemophilic arthropathy and Crohn’s disease who was at risk for pathogenic gastrointestinal bleeding. After undergoing endoscopic pathologic testing and genetic testing, a multidisciplinary expert work-up of a treatment and nutritional plan was performed. The patient improved clinically and adhered to conservative treatment. This case report is the first report of this rare co-morbidity, demonstrating the highly pathogenic mutation locus and summarizing the clinical experience of early diagnosis and treatment.