bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying proteins controlling key disease signaling pathways
Authors: Gitter Anthony , Bar-Joseph Ziv 
Published: June 2013

AbstractMotivation: Several types of studies, including genome-wide association studies and RNA interference screens, strive to link genes to diseases. Although these approaches have had some success, genetic variants are often only present in a small subset of the population, and screens are noisy with low overlap between experiments in different labs. Neither provides a mechanistic model explaining how identified genes impact the disease of interest or the dynamics of the pathways those genes regulate. Such mechanistic models could be used to accurately predict downstream effects of knocking down pathway members and allow comprehensive exploration of the effects of targeting pairs or higher-order combinations of genes.Results: We developed methods to model the activation of signaling and dynamic regulatory networks involved in disease progression. Our model, SDREM, integrates static and time series data to link proteins and the pathways they regulate in these networks. SDREM uses prior information about proteins’ likelihood of involvement in a disease (e.g. from screens) to improve the quality of the predicted signaling pathways. We used our algorithms to study the human immune response to H1N1 influenza infection. The resulting networks correctly identified many of the known pathways and transcriptional regulators of this disease. Furthermore, they accurately predict RNA interference effects and can be used to infer genetic interactions, greatly improving over other methods suggested for this task. Applying our method to the more pathogenic H5N1 influenza allowed us to identify several strain-specific targets of this infection.Availability: SDREM is available from http://sb.cs.cmu.edu/sdremContact: zivbj@cs.cmu.eduSupplementary information: Supplementary data are available at Bioinformatics online.
Experimental characterization of strain localization in rock
Authors: Zhang Hao , Huang Ganyun , Song Haipeng , Kang Yilan 
Published: June 2013

Abstract
In this study, damage evolution and strain localization in sandstone have been experimentally investigated in uniaxial compression tests. A digital image correlation technique has been applied to obtain apparent strain fields which can visually display the deformation and damage evolution of rock. The experimental results show that regions with apparent strain concentration (RASC) develop at the initial loading stage and distribute diffusely on the sample surface which may correspond to the damaged areas. With incremental load, the RASCs localize spatially, probably via coalescence into a line-shaped area that behaves like a macroscopic crack leading to the eventual failure of the specimen. A factor DRASC representing the deviation of the average apparent strain in RASCs from the average on the whole sample surface and a localization factor Lf, are proposed to characterize the evolution of damage and localization. DRASC increases slowly in the initial phase of loading and rises rapidly after the onset of localization. Lf decreases during loading which indicate the localization of spatial distribution of damage. The two factors can be used to well reflect the damage evolution and strain localization of rock specimens under compression.
Predicting house price via gene expression programming
Authors: Shekarian Ehsan , Fallahpour Alireza 
Published: June 2013

PurposeThe housing sector is one of the main sources of economic growth in both developing and developed countries. Although many methods for modeling house prices have been proposed, each has its own limitations. The present paper aims to propose gene expression programming (GEP) as a new approach for prediction of housing price.Design/methodology/approachThis study introduces gene expression programming (GEP) as a new approach for predicting housing price. This is the first time that this metaheuristic method is used in the housing literature.FindingsThe housing price model based on the gene expression programming is compared with a least square regression model that is derived from a stepwise process. The results indicate that the GEP‐based model provides superior performance to the traditional regression.Originality/valueData used in this study is derived from the Household Income and Expenditure Survey (HIES) in Iran that is conducted by the Statistical Center of Iran (SCI). Housing price model is estimated by administering the questionnaires of this survey in Hamedan Province. To show the applicability of the derived model by GEP technique, it is verified applying parts of the data, namely test data sets that were not included in the modeling process.
Formal housing finance outreach and the urban poor in India
Authors: Sandhu Kiran 
Published: June 2013

PurposeAccess to housing remains high on the agenda of the governments in the developing countries. One of the responses to low income housing access is by making the housing finance conduits reachable to the poor. But is this objective really achieved? The purpose of the research paper is to evaluate the access of formal housing finance specifically in the context of the urban poor in India.Design/methodology/approachThe purpose of the research is achieved by conducting a review into the available literature as well as drawing inferences from data in order to support the argument that the formal housing finance structures in India are failing to deliver to a majority of the population and primarily the urban poor when it comes to providing access to equitable housing. The paper uses qualitative method of research and analysis and presents the analysis in a descriptive approach.FindingsBased upon a comprehensive review of literature in terms of work of other authors, reports and documents, the paper generates evidence and critically examines the context of housing finance provision for the urban poor in India. It is found that the housing finance set‐up favours the higher income groups and sidelines the low income groups, largely due to the prerequisites for accessing housing finance.Practical implicationsThe research is perceived to be useful to policymakers and government organizations engaged in social housing to reflect on the fact that despite efforts, the outreach of finance is not adequate. It shall motivate them to re‐examine their credit policies and devise innovative mechanisms for housing finance delivery to the low income groups.Originality/valueThe paper presents a thorough and critical review of the housing finance structure with focus on the urban poor using current trends. It reflects on the issues and evidence so generated during research. The paper shall be useful to researchers in social housing and housing finance as well as decision makers in the Government in India and as a reference case for other countries in the developing world.
Management of the master data lifecycle: a framework for analysis
Authors: Hubert Ofner Martin , Straub Kevin , Otto Boris , Oesterle Hubert 
Published: June 2013

PurposeThe purpose of the paper is to propose a reference model describing a holistic view of the master data lifecycle, including strategic, tactical and operational aspects. The Master Data Lifecycle Management (MDLM) map provides a structured approach to analyze the master data lifecycle.Design/methodology/approachEmbedded in a design oriented research process, the paper applies the Component Business Model (CBM) method and suggests a reference model which identifies the business components required to manage the master data lifecycle. CBM is a patented IBM method to analyze the key components of a business domain. The paper uses a participative case study to evaluate the suggested model.FindingsBased on a participative case study, the paper shows how the reference model makes it possible to analyze the master data lifecycle on a strategic, a tactical and an operational level, and how it helps identify areas of improvement.Research limitations/implicationsThe paper presents design work and a participative case study. The reference model is grounded in existing literature and represents a comprehensive framework forming the foundation for future analysis of the master data lifecycle. Furthermore, the model represents an abstraction of an organization's master data lifecycle. Hence, it forms a “theory for designing”. More research is needed in order to more thoroughly evaluate the presented model in a variety of real‐life settings.Practical implicationsThe paper shows how the reference model enables practitioners to analyze the master data lifecycle and how it helps identify areas of improvement.Originality/valueThe paper reports on an attempt to establish a holistic view of the master data lifecycle, including strategic, tactical and operational aspects, in order to provide more comprehensive support for its analysis and improvement.
Selected FINRA notices and disciplinary actions, September 2012‐April 2013
Authors: Davis Henry A. 
Published: June 2013

PurposeThe purpose of this paper is to provide selected Financial Industry Regulatory Authority (FINRA) Regulatory Notices and Disciplinary Actions issued in June, July, and August 2012.Design/methodology/approachThe paper provides FINRA Regulatory Notice 12‐40, SEC Approves New FINRA Rule 5123 Regarding Private Placements of Securities; Regulatory Notice 12‐44, SEC Approves Amendments to FINRA Rule 4210 (Margin Requirements); Regulatory Notice 12‐55, Guidance on FINRA's Suitability Rule; and Regulatory Notice 13‐13, Trading and Quotation Halts in OTC Equity Securities; Trade Reporting Notice of April 17, 2013: Reduction of Reporting Times for Agency Pass‐Through Mortgage‐Backed Securities Traded TBA.FindingsNotice 12‐40: FINRA Rule 5123 is part of a multi‐pronged approach to enhance oversight and investor protection in private placements; the rule will provide FINRA with more timely and complete information about the private placement activities of firms on behalf of other issuers. Notice 12‐44: The SEC approved amendments to FINRA Rule 4210 (Margin Requirements) related to option spread strategies, maintenance margin requirements for non‐margin eligible equity securities, free‐riding, “exempt accounts” and stress testing in portfolio margin accounts. Notice 12‐55: This Notice addresses two issues discussed in Regulatory Notice 12‐25: the scope of the terms “customer” and “investment strategy.” Notice 12‐25 provided guidance in a “frequently asked questions” format in FINRA Rule 2111 (Suitability). Notice 13‐13: The SEC approved amendments to FINRA Rule 6440, which provides authority for FINRA to initiate trading and quotation halts in OTC equity securities in circumstances where it is necessary to protect investors and the public; the rule provides authority to impose foreign regulatory halts, derivative halts and extraordinary event halts. Trade Reporting Notice of April 17, 2013: FINRA reminds firms of the coming reduction in reporting periods for the timely reporting of transactions in agency pass‐through mortgage‐backed securities traded TBA (to be announced) for good delivery and products not traded for good delivery.Originality/valueThese FINRA notices are selected to provide a useful indication of regulatory trends.
Critical theory for women empowerment through ICT studies
Authors: Kenkarasseril Joseph Meera 
Published: June 2013

PurposeInformation and communication technology (ICT) is a powerful tool and an enabler of economic growth in under‐developed areas. ICTs have played an important role in women's development and provided opportunities for empowerment. ICTs have the potential to exchange information and empower marginalised communities. The purpose of this paper is to cover Habermas‐based critical theory to understand the politics of women's empowerment through the use of ICTs.Design/methodology/approachThe paper examines the role of ICTs in developing marginalised women from the coastal areas of southern India. The paper is based on a qualitative study and presents a set of questionnaires developed specifically to assess women's development through the use of ICTs.FindingsThis study presents Habermasian based approach to address women's developmental goals.Originality/valueThe paper provides meaningful discussion on ICT for Women's Development (ICT4WD) and explores theories related to the feminist inquiry.
Discourses of delusion in demanding times
Authors: Irving Barrie A. 
Published: June 2013

PurposeThe purpose of this paper is to demonstrate how critical discourse analysis can help to uncover the dominant discursive formations that underlie policy guidelines within education. Focusing on the policy guidelines for career education and guidance in New Zealand, it illustrates how these have been used by the state in an attempt to normalise ideological standpoints, shape “common‐sense” thinking and delimit the scope of practice.Design/methodology/approachCritical discourse analysis was employed as this approach helps to uncover the hidden meanings, political imperatives and uneven workings of power/dominance and oppression that are employed in/through textual representations.FindingsNeoliberal discourse is infused throughout the policy guidelines for career education and guidance in New Zealand, and demands that career advisers/teachers should produce entrepreneurial and self‐responsibilised global economic subjects.Research limitations/implicationsAlthough this paper is situated within a New Zealand context, given the creeping influence of neoliberalism in many English‐speaking states, the issues identified have international relevance in relation to the kind of citizen career education is expected to produce.Originality/valueMuch of the literature within the career arena adopts an uncritical, and apolitical, stance, with the truth‐claims made by neoliberal states tending to be positioned as authoritative and inviolable. Drawing from critical theory, this paper contributes a social justice perspective that looks beneath the surface of the seemingly benign and well‐intentioned discourses that permeate the guidelines for career education and guidance in New Zealand.
Long‐term prognosis after surgical excision of basal cell carcinoma: A single institutional study in Japan
Authors: Takenouchi Tatsuya , Takatsuka Sumiko 
Published: June 2013

AbstractConventional surgical excision (SE) is commonly used to treat patients with basal cell carcinoma (BCC). There have been few studies, however, evaluating the long‐term prognosis of Japanese patients receiving SE for treatment of BCC. The purpose of this retrospective study is to determine the effectiveness of SE in accomplishing the long‐term cure of patients with BCC. We enrolled 290 patients with primary BCC who underwent SE during 1998–2006. The prognosis of treated patients was subsequently investigated using data obtained through our hospital cancer registration section. In total, 205 patients (70.7%) were treated for BCC lesions located on the face. The mean tumor diameter of excised lesions was 12.8 mm. A majority of patients in the study (256 patients, 88.3%) had pigmented BCC. The mean surgical margin at SE was 3.8 mm. Two patients developed local recurrence during the postoperative course of 290 patients (mean duration, 80 months). One patient developed recurrent disease 21 months after surgery, and the other developed recurrence at 66 months after surgery. The 5‐ and 10‐year cumulative recurrence rates were 0.4% and 0.8%, respectively. In conclusion, this study demonstrated that long‐term high cure rates of BCC in Japanese patients may be achieved through conventional SE. A better prognosis was obtained in this study compared with similar studies reported previously in Caucasians. This may be related to the predominance of pigmented versus non‐pigmented lesions in the Japanese population.
Treatment burden in stage I seminoma: a comparison of surveillance and adjuvant radiation therapy
Authors: Leung Eric , Warde Padraig , Jewett Michael , Panzarella Tony , O'Malley Martin , Sweet Joan , Moore Malcolm , Sturgeon Jeremy , Gospodarowicz Mary , Chung Peter 
Published: June 2013

Objective
To examine the management and outcomes of patients with stage I seminoma and to relate these to overall treatment burden.
Patients and Methods
A total of 764 patients with stage I seminoma underwent surveillance or adjuvant radiation therapy (RT) at a single institution.
First relapse on surveillance was managed with RT alone, or with combination chemotherapy (ChT) for more extensive recurrence. Second relapse was managed with ChT.
Relapse after adjuvant RT was treated with ChT.
The treatment burden was measured, according to the specific treatment undertaken after orchiectomy, by defining treatment episodes as follows: surgery – one episode; one course of RT – one episode; one course of ChT – one episode.
Results
In all, 484 patients underwent surveillance and 280 received adjuvant RT. The 5‐ and 10‐year overall survival rates were 98.6 and 97.7% for surveillance, and 97.2 and 91.4% for adjuvant RT.
A total of 72 (15%) patients in the surveillance group relapsed; treatment for relapse was RT (n = 56), ChT (n = 15) and surgery (n = 1). Second relapse occurred in six patients; these patients were treated with ChT.
Of the patients in the adjuvant RT group, 14 (5%) relapsed: salvage treatment was 10 – ChT (n = 10) surgery (n = 1) and further RT (n = 3).
The overall treatment burden represented by number of treatment episodes per patient was 0.16 in the surveillance group and 1.05 in the adjuvant RT group.
Conclusions
Surveillance reduces the overall treatment burden in patients with stage I seminoma and is the preferred management option.
The selective use of RT at first relapse for patients on surveillance leads to a similar requirement for subsequent ChT to that for patients on adjuvant RT.
Sex Differences in the Cholinergic Basal Forebrain in the Ts65Dn Mouse Model of Down Syndrome and Alzheimer's Disease
Authors: Kelley Christy M. , Powers Brian E. , Velazquez Ramon , Ash Jessica A. , Ginsberg Stephen D. , Strupp Barbara J. , Mufson Elliott J. 
Published: June 2013

AbstractIn the Down syndrome (DS) population, there is an early incidence of dementia and neuropathology similar to that seen in sporadic Alzheimer's disease (AD), including dysfunction of the basal forebrain cholinergic neuron (BFCN) system. Using Ts65Dn mice, a model of DS and AD, we examined differences in the BFCN system between male and female segmentally trisomic (Ts65Dn) and disomic (2N) mice at ages 5–8 months. Quantitative stereology was applied to BFCN subfields immunolabeled for choline acetyltransferase (ChAT) within the medial septum/vertical limb of the diagonal band (MS/VDB), horizontal limb of the diagonal band (HDB) and nucleus basalis of Meynert/substantia innominata (NBM/SI). We found no sex differences in neuron number or subregion area measurement in the MS/VDB or HDB. However, 2N and Ts65Dn females showed an average 34% decrease in BFCN number and an average 20% smaller NBM/SI region area compared with genotype‐matched males. Further, relative to genotype‐matched males, female mice had smaller BFCNs in all subregions. These findings demonstrate that differences between the sexes in BFCNs of young adult Ts65Dn and 2N mice are region and genotype specific. In addition, changes in post‐processing tissue thickness suggest altered parenchymal characteristics between male and female Ts65Dn mice.
Metrics of salbutamol use as predictors of future adverse outcomes in asthma
Authors: Patel M. , Pilcher J. , Reddel H. K. , Pritchard A. , Corin A. , Helm C. , Tofield C. , Shaw D. , Black P. , Weatherall M. , Beasley R. 
Published: June 2013

SummaryBackgroundBeta‐agonist overuse is associated with adverse outcomes in asthma, however, the relationships between different metrics of salbutamol use and future risk are uncertain.ObjectiveTo investigate the relationship between metrics of salbutamol use and adverse outcome.MethodsIn a 24‐week randomized controlled trial of 303 asthma patients at risk of severe exacerbations which compared the efficacy and safety of combination budesonide/formoterol inhaler according to a single inhaler regimen (SMART) with a fixed‐dose regimen with salbutamol as reliever (‘Standard’), actual medication use was measured by electronic monitoring (Australian New Zealand Clinical Trials Registry Number ACTRN12610000515099). A nested cohort study explored the relationship between metrics of baseline salbutamol use over 2 weeks and future severe asthma exacerbations, poor asthma control (ACQ‐5 ≥ 1.5) or ‘extreme’ salbutamol overuse (> 32 salbutamol actuations/24‐h period).ResultsHigher mean daily salbutamol use (per two actuations/day) [Odds ratio (OR) (95% CI) 1.24 (1.06–1.46)], higher days of salbutamol use (per 2 days in 2 weeks) [OR 1.15 (1.00–1.31)] and higher maximal 24‐h use (per two actuations/day) [OR 1.09 (1.02–1.16)] were associated with future severe exacerbations. Higher mean daily salbutamol use was associated with future poor asthma control [OR 1.13 (1.02–1.26)]. Higher mean daily salbutamol use [OR 2.73 (1.84–4.07)], number of days of use [OR 1.46 (1.24–1.71)], and maximal daily use [OR 1.57 (1.31–1.89)] were associated with an increased risk of future extreme salbutamol overuse.Conclusion and Clinical RelevanceElectronically recorded frequency of current salbutamol use is a strong predictor of risk of future adverse outcomes in asthma, with average daily use performing the best. These findings provide new information for clinicians considering metrics of salbutamol as predictors of future adverse outcomes in asthma.
Perceptions of clinicians treating young people with first‐episode psychosis for post‐traumatic stress disorder
Authors: Gairns Sarah , Alvarez‐Jimenez Mario , Hulbert Carol , McGorry Patrick , Bendall Sarah 
Published: June 2013

AbstractAimEvidence shows that approximately half of young people with first‐episode psychosis have post‐traumatic stress disorder. Yet, post‐traumatic stress disorder is often left untreated in the presence of psychosis. To support the development of a post‐traumatic stress disorder intervention for young people with first‐episode psychosis, clinicians' perceptions of trauma‐focused interventions were sought. Two research questions were explored: What treatment barriers were associated with treating young people with first‐episode psychosis? What supports would be useful to implement post‐traumatic stress disorder intervention?MethodsA mixed‐methods design incorporated quantitative and qualitative data from a questionnaire with qualitative data from two focus groups. Sixteen (of 20) case managers from an early psychosis intervention centre participated in the study (16 completed a questionnaire, eight participated in focus groups). Descriptive statistics were generated for quantitative data and qualitative material was examined using a grounded theory approach.ResultsThe results showed that perceived barriers to delivering trauma‐focused intervention were increased mental health risks for clients with psychosis, workload pressures and poor client engagement. Targeted training and formal professional guidance were thought to best scaffold an intervention.ConclusionsPost‐traumatic stress disorder intervention for first‐episode psychosis clients should address engagement, make safeguarded provisions for family involvement and be sufficiently paced and flexible. Trauma‐focused intervention is perceived with a degree of caution, is often not prioritized, lacks institutional support and requires more targeted training. It is important to conduct further research regarding the safety of trauma interventions alongside psychosis in order to address widespread concerns.