bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the Energy Intensity of Ammonia Production by Microbubbles
Authors: Kubicsek Ferenc , Hegedűs Ferenc 
Published: February 2025

The present paper investigates the energy intensity of ammonia production by a freely oscillating microbubble placed in an infinite liquid domain. The spherical bubble initially contains a mixture of nitrogen and hydrogen. The bubble is expanded from its equilibrium size to a specific maximum radius via an isothermal expansion. The work needed to expand the bubble is its potential energy calculated by the sum of the work done by the internal gas, the work needed to displace the mass of the surrounding liquid, and the work needed to increase the area of the bubble against the surface tension. During the radial pulsation of the freely oscillating bubble, the internal temperature can reach several thousands of kelvin inducing chemical reactions. The chemical yield is computed by solving a set of ordinary differential equations describing the radial dynamics of the bubble (Keller—Miksis equation), the temporal evolution of the internal temperature (first law of thermodynamics), and the concentrations of the chemical species (reaction mechanism). The control parameters during the simulations were the equilibrium bubble size, the initial expansion ratio, the ambient pressure, and the initial concentration ratio of nitrogen and hydrogen. In the best-case scenario, the energy requirement in terms of GJ/t is 18.4 times higher than the best available facility of the Haber—Bosch process (assuming that the hydrogen is produced via the electrolysis of water).
Faktor- Faktor yang Mempengaruhi Tingkat Profitabilitas Bank Umum Syariah Di Indonesia
Authors: Arsal Muryani , Rusli Andi Musyarrafah , Badoahi Ismail 
Published: February 2025

This aims of study to examine the effect of financial ratios which is Capital Adequacy Ratio (CAR), Operating Costs Operating Income (BOPO), Non Performing Financing (NPF), Financing to Deposit Ratio (FDR), and Inflation Rate on profitability in Sharia Commercial Banks in Indonesia for the 2018-2022 period. This research used quantitative research where using secondary data from the financial reports of Sharia Commercial Banks. The data analysis technique used is multiple linear regression. The research results show that BOPO, NPF, and FDR have a significant effect on profitability, while CAR and the Inflation Rate do not have a significant effect. This research contributes to understanding the factors that influence the profitability of Sharia Commercial Banks in Indonesia, so that it can be a consideration for management in making strategic decisions regarding financial management and bank operations.
Analisis Faktor-Faktor Konsumen Terhadap Purchase Intention Sepeda Listrik Menggunakan TAM3
Authors: Belananda Maulia Regita , Ian Muhammad Rezki , Jamal Jamal 
Published: February 2025

of people's strong purchasing power and the reasonable cost of electric bicycles. Purposive sampling was employed in questionnaire sampling. Because this study has forty indikator items, it requires a sample size of 200 respondents. The TAM3 model, which has 17 variables, is used in the research model. Only three variables—Subjective Norm, work relevance, and Output Quality—are known to be partially significant and to positively impact Perceived Usefulness . Five factors are identified as partially significant determinants of Perceived Ease of Use; three factors are positively correlated: Self-efficacy, Playfulness, and enjoyment; the other two are negatively correlated: Anxiety and Objective Usability. Perceived Usefulness and Perceived Ease of Use are partially known to have a positive and significant influence on Behavioral Intention. Then it is known that Behavioral Intention has a positive and significant influence on Purchase Intention.
Pengungkapan Perbankan Hijau dan Kinerja Bank Syariah di Indonesia: Eksplorasi Hubungan dan Peran Moderasi Regulasi
Authors: Khomsatun Siti , Aryani Habsyah Fitri , Pramesti Adista Ika 
Published: February 2025

The impact of globalization on economic growth has been predominantly negative, as widely noted. There is a need for environmental responsibility, including within Islamic banking. The environmental responsibility of Islamic banking aligns with the fundamental objectives of Sharia or maqashid sharia. Therefore, the aim of this study is to explore the relation of green banking disclosure and the maqasid shariah performance. The second objective is to investigate the moderating role of regulations on the relation of green banking disclosure and maqashid Shariah performance. This research utilizes 92 observations from 16 Islamic banks from 2017 to 2023, with employing an unbalanced panel data. Moderated regression analysis is conducted for each dimension of green banking disclosure. The findings indicate that green banking disclosure related to employees and customers dimension positively impact on maqashid sharia performance, which is the daily operational dimension of green demonstrates a significant negative. While the policy dimension of green banking shows no effect. Another finding of this study is the absence of evidence for moderation by regulation SEOJK No. 16 of 2021. However, if using 10% significance level, moderation role of regulation indicates that regulations weaken the negative effect of daily operational dimensions on maqashid Sharia performance.
3D connective micro-fragment enriched with stromal vascular fraction in osteoarthritis: chondroprotective evidence in a preclinical in vivo model
Authors: Desando Giovanna , Tschon Matilde , Martini Lucia , Sartori Maria , Giavaresi Gianluca , Fini Milena , Cellamare Antonella , Soranzo Carlo , Longinotti Cristina , D’Alessandro Martina , Roseti Livia , Grigolo Brunella 
Published: February 2025

IntroductionAdipose-derived cell therapies are one of the most common regenerative therapeutic options to alleviate the multi-component damage of osteoarthritis (OA). Adipose stromal vascular fraction (SVF) has gained scientific consensus for its ability to interact protectively with the joint microenvironment. Recently, the wide range of enzyme-free tissue processing systems has outperformed classical treatments, because of their ability to produce connective micrografts enriched with the SVF (mctSVF). This preclinical in vivo study evaluates the chondroprotective potential of a newly generated mctSVF compared with in vitro expanded adipose stromal cells (ASC) in OA.MethodsA mild grade of OA was induced through bilateral anterior cruciate ligament transection (ACLT) surgery in 32 Specific Pathogen Free (SPF) Crl: KBL (NZW) male rabbits followed by the surgical excision of inguinal adipose tissue. After 2 months, OA joints were treated with an intra-articular (IA) injection of mctSVF or ASC. Local biodistribution analysis was used to determine migration patterns of PKH26-labelled cells in the knee joint after 1 month. Efficacy was assessed by gross analysis, histology and immunohistochemistry on the osteochondral unit, synovial membrane and meniscus.ResultsWe elucidate the effectiveness of a one-step approach based on mechanical isolation of mctSVF. Through epifluorescence analysis, we found a similar pattern of cell distribution between cell treatments, mainly towards articular cartilage. Similar regenerative responses were observed in all experimental groups. These effects included: (i) osteochondral repair (promotion of typical anabolic markers and reduction of catabolic ones); (ii) reduction of synovial reactions (reduced synovial hypertrophy and inflammation, and change of macrophage phenotype to a more regenerative one); and (iii) reduction of degenerative changes in the meniscus (reduction of tears).DiscussionOur study demonstrates the validity of a novel mechanical system for the generation of the mctSVF micrograft with chondroprotective potential in a preclinical model of moderate OA. The resulting final product can counteract inflammatory processes beyond the OA microenvironment and protect cartilage through the colonization of its structure. The intact and active microanatomy of mctSVF makes it a suitable candidate for translational medicine to treat OA without the need for cell manipulation as with ASC.
Filtered and unfiltered lipoaspirates reveal novel molecular insights and therapeutic potential for osteoarthritis treatment: a preclinical in vitro study
Authors: Behn Alissa , Brendle Saskia , Ehrnsperger Marianne , Zborilova Magdalena , Grupp Thomas M. , Grifka Joachim , Schäfer Nicole , Grässel Susanne 
Published: February 2025

IntroductionOrthobiologics, such as autologous nanofat, are emerging as a potential treatment option for osteoarthritis (OA), a common degenerative joint causing pain and disability in the elderly. Nanofat, a minimally processed human fat graft rich in stromal vascular fraction (SVF) secretory factors, has shown promise in relieving pain. This study aimed to elucidate the molecular mechanisms underlying nanofat treatment of OA-affected cells and compare two filtration systems used for nanofat preparation.MethodsChondrocytes and synoviocytes were isolated from articular cartilage and synovium of 22 OA-patients. Lipoaspirates from 13 OA-patients were emulsified using the Adinizer® or Lipocube™ Nano filter systems to generate nanofat. The fluid phase of SVF from both filtered and unfiltered lipoaspirates was applied to OA-affected cells. Luminex multiplex ELISA were performed with lipoaspirates and cell supernatants alongside functional assays evaluating cell migration, proliferation, metabolic activity, and senescence.ResultsA total of 62 cytokines, chemokines, growth factors, neuropeptides, matrix-degrading enzymes, and complement components were identified in lipoaspirates. Among these, significant concentration differences were observed for TIMP-2, TGF-ß3, and complement component C3 between the filtered and unfiltered samples. Nanofat enhanced chondrocyte proliferation and migration, as well as synoviocyte migration and metabolic activity, while reducing chondrocyte metabolic activity. Pain-related factors like β-NGF, MCP-1, Substance P, VEGF, and αCGRP were reduced, while anti-inflammatory TGF-β1+3 increased and pro-inflammatory cytokines (IL-5, IL-7, IL-15, and IFN-γ) decreased. Nanofat also elevated secretion of complement components and TIMPs in both cell types. Notably, our results revealed no significant differences in cellular effects between sSVF filtered using the Adinizer® and Lipocube™ Nano systems, as well as compared to unfiltered sSVF.DiscussionHere, we provide first insights into how autologous nanofat therapy may ameliorate OA by enhancing chondrocyte proliferation and synoviocyte migration while modulating inflammatory and pain-related factors. However, further research is needed to determine its effects on cartilage regeneration.
Designing novel cabozantinib analogues as p-glycoprotein inhibitors to target cancer cell resistance using molecular docking study, ADMET screening, bioisosteric approach, and molecular dynamics simulations
Authors: Thakur Gajendra Singh , Gupta Ajay Kumar , Pal Dipti , Vaishnav Yogesh , Kumar Neeraj , Annadurai Sivakumar , Jain Sanmati Kumar 
Published: February 2025

IntroductionOne of the foremost contributors to mortality worldwide is cancer. Chemotherapy remains the principal strategy for cancer treatment. A significant factor leading to the failure of cancer chemotherapy is the phenomenon of multidrug resistance (MDR) in cancer cells. The primary instigator of MDR is the over expression of P-glycoprotein (P-gp), a protein that imparts resistance and facilitates the ATP-dependent efflux of various anticancer agents. Numerous efforts have been made to inhibit P-gp function with the aim of restoring the effectiveness of chemotherapy due to its broad specificity. The main objective has been to create compounds that either serve as direct P-gp inhibitors or interact with cancer therapies to modulate transport. Despite substantial in vitro achievements, there are currently no approved drugs available that can effectively “block” P-gp mediated resistance. Cabozantinib (CBZ), a multi-kinase inhibitor, is utilized in the treatment of various carcinomas. CBZ has been shown to inhibit P-gp efflux activity, thereby reversing P-gp mediated MDR. Consequently, P-gp has emerged as a critical target for research in anti-cancer therapies.MethodsThe purpose of this study was to computationally identify new andsafer analogues of CBZ using bioisosteric approach, focusing on improved pharmacokinetic properties andreduced toxicity. The physicochemical, medicinal, and ADMET profiles of generated analogues were computed using the ADMETLab 3.0 server. We also predicted the drug likeness (DL) and drug score (DS) of analogues. The molecular docking studies of screened analogues against the protein (PDB ID: 3G5U) were conducted using AutoDock Vina flowing by BIOVIA Discovery Studio for visualizing interactions.Molecular dynamics (MD) simulation of docked ligands was done using Schrödinger suite.Results and DiscussionThe docking scores for the ligands CBZ01, CBZ06, CBZ11, CBZ13, CBZ25, CBZ34, and CBZ38 ranged from −8.0 to −6.4 kcal/mol against the protein (PDB ID: 3G5U). A molecular dynamics (MD) simulation of CBZ01, CBZ13, and CBZ38 was conducted using the Schrödinger suite, revealing that these complexesmaintained stability throughout the 100 ns simulation.ConclusionAn integrated computational approach combining bioisosteric approach, molecular docking, drug likeness calculations, and MD simulations highlights the promise of ligands CBZ01 and CBZ13 as candidates for the development of potential anticancer agents for the treatment of various cancers.
Antimicrobial and cytotoxic activities of natural (Z)-13-docosenamide derived from Penicillium chrysogenum
Authors: El-Gazzar Nashwa , Said Lekaa , Al-Otibi Fatimah Olyan , AbdelGawwad Mohamed Ragab , Rabie Gamal 
Published: February 2025

IntroductionThe synthesis of natural compounds with strong biological activity from affordable sources has proven challenging for scientists. As a natural resource rich in a variety of bioactive substances, fungal metabolites have the potential to be used in medical applications to serve a global purpose towards a sustainable future.MethodsA total of 25 filamentous fungi were isolated, and their secondary metabolites were assessed for their antimicrobial efficiency. ResultsThe extracellular extract of the strain Penicillium chrysogenum Pc was selected for its high bioactivity compared with the other whole isolates. The GC-MS analysis of the extracellular extract of P. chrysogenum Pc was found to contain approximately 16 variable compounds. After several separation and purification processes using flash chromatography, HPLC, TLC, NMR, and FTIR, the most bioactive compound was identified as (Z)-13-docosenamide or erucylamide with a molecular formula of C22H43NO and a molecular weight of 337.0. The purified (Z)-13-docosenamide possessed antimicrobial activity with an MIC of approximately 10 μg/mL for the tested pathogenic bacteria (Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli), and 20 μg/mL against the tested fungi (Penicillium aurantiogriseum and Aspergillus fumigatus). Furthermore, MTT assay showed that (Z)-13-docosenamide inhibited cellviability and the proliferation of hepatocellular carcinoma, in vitro, with an IC {sb}{/sb}50 of 23.8 ± 0.8 μg/mL.ConclusionThe remarkable bioactivity of (Z)-13- docosenamide makes it a potential candidate to assist the pipeline for the creation of antibacterial and anticancer drugs, which will help to reduce the incidence of antimicrobial resistance (AMR) and fatalities related to cancer.
Myocardial intramural course may reduce left ventricular ejection fraction of patients suffering from coronary heart disease
Authors: Miaomiao Shi , Jiaqi Zheng , Xiaomeng Li , Shanshan Li , Jie Wang , Kaicheng Liu , Mei Jia , Ming Su 
Published: February 2025

BackgroundMyocardial intramural course (MIC), a benign anatomical lesion, is an abnormal anatomical structure formed due to abnormal blood vessel routing. An increasing number of studies indicate that MIC is associated with coronary heart disease (CHD). However, it remains unclear whether MIC contributes to cardiac function impairment in patients with CHD. Thus, this study is to observe the association between MIC and cardiac function in patients with CHD.MethodsAll participants were recruited from the Department of Cardiology, Peking University People's Hospital from August 2022 to September 2023. A total of 126 patients were diagnosed with MIC by coronary angiography and/or coronary CT angiography. Among them, a total of 39 patients diagnosed with MIC and CHD were enrolled in the MIC-CHD group. Sixty cases of monthly stratified CHD patients were randomly selected, into the CHD group as controls.ResultsThe left ventricular ejection fraction (LVEF) of patients in the MIC-CHD group was lower than that in the CHD group (0.62 vs. 0.67, p = 0.0153). LVEF in patients of MIC-CHD was negatively correlated with the systolic stenosis degree of mural coronary artery (MCA) (r = −0.6474, p = 0.0123) and MIC length (r = −0.5712, p = 0.0414).ConclusionsThe combination of MIC in patients with CHD may contribute to the reduction of LVEF, whereas MIC length and the systolic stenosis degree of MCA were negatively correlated with LVEF.
Case Report: Dual-chamber pacemaker for hypertrophic cardiomyopathy with bradyarrhythmia and idiopathic pericardial effusion: a report of two cases and literature review
Authors: Liu Chang , Zheng Fei , Gao Yuxia , Wang Zheming , Zhang Xinyu , Tian Xiuqing 
Published: February 2025

BackgroundHypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder characterized by asymmetric hypertrophy of the ventricles and the ventricular septum, leading to subsequent left ventricular outflow tract (LVOT) obstruction and diastolic dysfunction. Typically, patients with HCM experience sinus tachycardia and sinus arrest relatively infrequently. In addition, the concurrent occurrence of HCM with non-surgically induced (ablation or myectomy) bradyarrhythmia and idiopathic pericardial effusion in adult patients has not been previously reported.Case summaryIn this report, we present two elderly female patients with HCM who exhibited sinus bradycardia and sinus arrest, one of whom also presented with moderate pericardial effusion, they all presented with chest tightness. To manage the complex comorbidities, we opted for dual-chamber pacemaker implantation. Subsequent examinations and follow-up revealed that pacing significantly reduced LVOT obstruction and corrected heart rhythm. Additionally, there was no significant progression of pericardial effusion.DiscussionThe primary strategies for alleviating LVOT obstruction involve altering the structure of the septum, including septal myectomy (SME), alcohol septal ablation (ASA), and septal radiofrequency ablation. Meanwhile, a dual-chamber pacemaker can treat HCM by changing the sequence of myocardial contraction. Although pacemakers have been considered an inferior alternative due to their relatively large residual obstruction, their benefits may be significantly underestimated. This report underscores the additional efficacy of dual-chamber pacemakers in managing HCM, particularly in patients complicated by sinus node dysfunction and idiopathic pericardial effusion.
Biogenic polymer based patches for congenital cardiac surgery: future development of implants
Authors: Richert Emma , Grefen Linda , Zorin Alexandra , Hubrich Julian , Simon Stefan , Sommerhoff Christian P. , Hagl Christian , Herz Christopher , Obrist Dominik , Hörer Jürgen , Carrel Thierry , Grab Maximilian , Heinisch Paul Philipp 
Published: February 2025

ObjectiveDespite advancements in surgical techniques, many patients born with congenital heart defects (CHD) require repeated reinterventions due to the limitations of materials used in congenital cardiac surgery (CCS). Traditional biogenic polymers, such as bovine or equine pericardium, are prone to calcification, have limited durability, and fail to adapt to the growth of infants. This study aims to address these challenges by investigating bacterial cellulose (BC) as a promising material for CCS.MethodsVariability in patch quality from previous studies was addressed by refining the production protocol taking advantage of optical density (OD) measurements. After a 72 h incubation, patches were harvested and tested mechanically with burst pressure and uniaxial strain testing. BC's biomechanical properties were further explored by modifying nutrient concentrations, creating different media groups (N10, N30, N50). Hybrid patches combining BC with electrospun polyurethane (ESP-PU) were developed using a specially designed 3D-printed flask to ensure uniform coating and integration.ResultsThe initial bacterial concentration significantly influenced cellulose yield and growth rate, with static cultures outperforming shaken ones. Nutrient-enriched media (N10, N30, N50) produced cellulose with greater elasticity and strength compared to standard C-Medium, with stiffness correlating to nutrient concentration. Inflation tests showed that N10 and N30 samples withstood higher pressures than N50, which, despite being stiffer, performed worse under rapid inflation. All samples, however, maintained pressures above physiological levels. Scanning electron microscopy analysis confirmed effective BC coating of PU fibres without altering BC fibre orientation or bacterial activity.ConclusionBC patches demonstrated burst pressure resistance above 1,400 mmHg. BC's elasticity can be tailored, and in combination with ESP-PU, an innovative hybrid material can be produced, positioning BC as a promising biomaterial for future CCS implant development.
The impact of urban polycentralization and scale expansion on economic efficiency: evidence from Chinese cities
Authors: Jiang Xinyang , Wei Siyi , Yi Chen , Liu Siyu , Yang Bo , Wu Yao 
Published: February 2025

IntroductionThis study investigates the effects of urban polycentricity and city size on total factor productivity (TFP) in Chinese cities.MethodsUsing high-resolution population distribution data from Landscan and applying instrumental variable (IV) estimation to address endogeneity concerns, we construct a novel measure of urban polycentricity.ResultsOur findings show that while expanding city size enhances TFP through increased economies of scale, greater urban polycentricity negatively affects productivity by weakening agglomeration economies and innovation spillovers.DiscussionThe analysis suggests that polycentricity reduces the concentration of economic activities, which hampers knowledge diffusion and innovation, leading to lower productivity. Additionally, we identify the optimal city size for maximizing TFP, where excessive urban growth beyond a certain point becomes counterproductive.