bluuebunny/crossref_metadata_2025_split huggingface dataset:
Idiopathic bilateral vocal cord paralysis in infants: Case series and literature review
Authors: Lesnik Maria , Thierry Briac , Blanchard Marion , Glynn Fergal , Denoyelle Françoise , Couloigner Vincent , Garabedian Noël , Leboulanger Nicolas 
Published: November 2014

Objectives/HypothesisVocal fold paralysis is the second most common congenital laryngeal anomaly in newborns. Bilateral paralysis is a severe condition and often remains of unknown etiology. We report our experience of congenital idiopathic bilateral vocal fold paralysis in newborns and infants, and discuss the therapeutic options.Study DesignRetrospective review.MethodsA retrospective review was carried out at a single tertiary referral center over a 15‐year period of children presenting with congenital idiopathic bilateral laryngeal paralysis (CIBP).ResultsTwenty‐six patients were identified and managed over period of the study (mean follow‐up, 6.7 years). A tracheostomy was eventually performed in 14 patients, 12 during the neonatal period. Endoscopic treatment was performed in 16 patients and an external approach in five patients after endoscopic failure. Three patients were managed by watchful waiting. Spontaneous recovery occurred in 16 patients (median age, 14.5 months), including nine with a tracheostomy. Decannulation was achieved in 12 patients (median age, 42 months), and noninvasive positive pressure ventilation (NPPV) was applied in six patients.ConclusionsOnly inhomogeneous series of pediatric bilateral laryngeal palsies have been published so far, making it difficult to identify prognostic and predictive markers, as well as therapeutic guidelines. Focusing on CIBP, our data suggest that the management strategy must take into account the possibility of a delayed spontaneous recovery. NPPV is an interesting therapeutic tool in this situation. A systematic somatic assessment is mandatory to look for associated conditions.Level of Evidence4 Laryngoscope, 125:1724–1728, 2015
First Appraisal of the Current Structure of Research on Land and Soil Degradation as Evidenced by Bibliometric Analysis of Publications on Desertification
Authors: Escadafal Richard , Barbero‐Sierra Celia , Exbrayat Williams , Marques Maria Jose , Akhtar‐Schuster Mariam , El Haddadi Anass , Ruiz Manuel 
Published: November 2014

AbstractFighting land and soil degradation is in the mandate of the United Nations Convention to Combat Desertification (UNCCD). However, it is often suggested that a lack of scientific guidance has resulted from inadequate institutional mechanisms to channel science into UNCCD decision making, rather than from a lack of research on UNCCD‐related issues. To explore this issue in more depth, this study explores the corpus of international publications dealing with land and/or with soil degradation. We extracted information from the ‘Web of Science’. By applying bibliometric methods and data mining, we mapped the key actors (laboratories, teams, and institutions) involved in research on land and on soils. Several filters were applied to the databases in combination with the word ‘desertification’. The further use of text mining software (Tetralogie®) allowed the analyses of similarities and differences between keywords, disciplines, authors, and regions and identifies obvious clusters. Understanding interconnections between these clusters ultimately allowed a first diagnosis of some of the strengths and weaknesses of the scientific community dealing with desertification. This type of detailed analyses can contribute to clarify the scientific landscape at large, and further in‐depth studies could lead to improvements in the way scientific advice is channeled into the UNCCD. Copyright © 2015 John Wiley & Sons, Ltd.
3‐Chlorotyramine Acting as Ligand of the D2Dopamine Receptor. Molecular Modeling, Synthesis and D2Receptor Affinity
Authors: Angelina Emilio , Andujar Sebastian , Moreno Laura , Garibotto Francisco , Párraga Javier , Peruchena Nelida , Cabedo Nuria , Villecco Margarita , Cortes Diego , Enriz Ricardo D. 
Published: November 2014

AbstractWe synthesized and tested 3‐chlorotyramine as a ligand of the D2dopamine receptor. This compound displayed a similar affinity by this receptor to that previously reported for dopamine. In order to understand further the experimental results we performed a molecular modeling study of 3‐chlorotyramine and structurally related compounds. By combining molecular dynamics simulations with semiempirical (PM6), ab initio and density functional theory calculations, a simple and generally applicable procedure to evaluate the binding energies of these ligands interacting with the D2dopamine receptors is reported here. These results provided a clear picture of the binding interactions of these compounds from both structural and energetic view points. A reduced model for the binding pocket was used. This approach allowed us to perform more accurate quantum mechanical calculations as well as to obtain a detailed electronic analysis using the Quantum Theory of Atoms in Molecules (QTAIM) technique. Molecular aspects of the binding interactions between ligands and the D2dopamine receptor are discussed in detail. A good correlation between the relative binding energies obtained from theoretical calculations and experimental IC50 values was obtained. These results allowed us to predict that 3‐chlorotyramine possesses a significant affinity by the D2‐DR. Our theoretical predictions were experimentally corroborated when we synthesized and tested 3‐chlorotyramine which displayed a similar affinity by the D2‐DR to that reported for DA.
IL‐1α induces CD11blow alveolar macrophage proliferation and maturation during granuloma formation
Authors: Huaux François , Lo Re Sandra , Giordano Giulia , Uwambayinema Francine , Devosse Raynal , Yakoub Yousof , Panin Nadtha , Palmai‐Pallag Mihaly , Rabolli Virginie , Delos Monique , Marbaix Etienne , Dauguet Nicolas , Couillin Isabelle , Ryffel Bernhard , Renauld Jean‐Christophe , Lison Dominique 
Published: November 2014

AbstractMacrophages play a central role in immune and tissue responses of granulomatous lung diseases induced by pathogens and foreign bodies. Circulating monocytes are generally viewed as central precursors of these tissue effector macrophages. Here, we provide evidence that granulomas derive from alveolar macrophages serving as a local reservoir for the expansion of activated phagocytic macrophages. By exploring lung granulomatous responses to silica particles in IL‐1‐deficient mice, we found that the absence of IL‐1α, but not IL‐1β, was associated with reduced CD11bhigh phagocytic macrophage accumulation and fewer granulomas. This defect was associated with impaired alveolar clearance and resulted in the development of pulmonary alveolar proteinosis (PAP). Reconstitution of IL‐1α−/− mice with recombinant IL‐1α restored lung clearance functions and the pulmonary accumulation of CD11bhigh phagocytic macrophages. Mechanistically, IL‐1α induced the proliferation of CD11blow alveolar macrophages and differentiated these cells into CD11bhigh macrophages which perform critical phagocytic functions and organize granuloma. We newly discovered here that IL‐1α triggers lung responses requiring macrophage proliferation and maturation from tissue‐resident macrophages. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease
Authors: Paquet Claire , Amin Jay , Mouton‐Liger François , Nasser Mariam , Love Seth , Gray Françoise , Pickering Ruth M , Nicoll James AR , Holmes Clive , Hugon Jacques , Boche Delphine 
Published: November 2014

AbstractAmyloid β peptide (Aβ) immunization of Alzheimer's disease (AD) patients has been reported to induce amyloid plaque removal, but with little impact on cognitive decline. We have explored the consequences of Aβ immunotherapy on neurons in post mortem brain tissue. Eleven immunized (AN1792, Elan Pharmaceuticals) AD patients were compared to 28 non‐immunized AD cases. Immunohistochemistry on sections of neocortex was performed for neuron‐specific nuclear antigen (NeuN), neurofilament protein (NFP) and phosphorylated‐(p)PKR (pro‐apoptotic kinase detected in degenerating neurons). Quantification was performed for pPKR and status spongiosis (neuropil degeneration), NeuN‐positive neurons/field, curvature of the neuronal processes and interneuronal distance. Data were corrected for age, gender, duration of dementia and APOE genotype and also assessed in relation to Aβ42 and tau pathology and key features of AD. In non‐immunized patients, the degree of neuritic curvature correlated with spongiosis and pPKR, and overall the neurodegenerative markers correlated better with tau pathology than Aβ42 load. Following immunization, spongiosis increased, interneuronal distance increased, while the number of NeuN‐positive neurons decreased, consistent with enhanced neuronal loss. However, neuritic curvature was reduced and pPKR was associated with Aβ removal in immunized patients. In AD, associations of spongiosis status, curvature ratio and pPKR load with microglial markers Iba1, CD68 and CD32 suggest a role for microglia in neurodegeneration. After immunization, correlations were detected between the number of NeuN‐positive neurons and pPKR with Iba1, CD68 and CD64, suggesting that microglia are involved in the neuronal loss. Our findings suggest that in established AD this form of active Aβ immunization may predominantly accelerate loss of damaged degenerating neurons. This interpretation is consistent with in vivo imaging indicating an increased rate of cerebral atrophy in immunized AD patients. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Spectral and dynamical study of III–V triple junction solar cells and the application to multiflash I–V measurement
Authors: Socolovsky Hernán. , Yaccuzzi Exequiel , Plá Juan 
Published: November 2014

AbstractThis paper presents a method to predict the I–V characteristic of triple junction InGaP/GaAs/Ge solar cells when different illumination spectra are used, and it is based on the measurement of a set of commercial isotype cells together with numerical simulations. The study includes the utilization of continuous and pulsed light sources. Several spectra were considered for the continuous light sources, where different subcells limit the current of the tandem cell. For pulsed light sources, a dynamical analysis was carried out by simulating a triple junction cell through PSpice software. For the simulations, the subcell capacitances were estimated and introduced into an electrical model of the triple junction. When a fast pulse in the multiflash I–V measurement technique is used, dynamical effects associated with this kind of source were observed and accounted for by the simulations. It was established that the dynamical effects did not affect the I–V characteristics measured with this technique. Finally, the proposed method and analysis were successfully applied to the electrical characterization of the Aquarius/SAC‐D Argentine satellite solar array modules. Copyright © 2014 John Wiley & Sons, Ltd.
New electroactive and electrochromic aromatic polyamides with ether‐linked bis(triphenylamine) units
Authors: Hsiao Sheng‐Huei , Cheng Shou‐Lun 
Published: November 2014

ABSTRACTA new class of electroactive polyamides with ether‐linked bis(triphenylamine) [O(TPA)2] units were prepared through the direct phosphorylation polycondensation from N,N‐di(4‐aminophenyl)‐N′,N′‐diphenyl‐4,4′‐oxydianiline and aromatic dicarboxylic acids. These polyamides were amorphous with good solubility in many organic solvents, such as NMP and DMAc, and could be solution‐cast into strong and flexible polymer films. Their decomposition temperatures (Td) at a 10% weight‐loss in nitrogen and air were recorded at 556–568 °C and 537–555 °C, respectively. The glass‐transition temperatures (Tg) of all the polyamides were observed in the range of 218−253 °C by DSC. Cyclic voltammograms of the polyamide films cast onto an indium‐tin oxide (ITO)‐coated glass substrate exhibited two reversible oxidation redox couples at 0.80–0.82 V and 0.96–0.98 V versus Ag/AgCl in an electrolyte containing acetonitrile solution. The polyamide films showed excellent electrochemical and electrochromic stability, with a color change from a colorless or pale yellowish neutral form to green and purple oxidized forms at applied potentials ranging from 0 to 1.2 V. These polymers can also be used to fabricate electrochromic devices, and they showed high coloration efficiency, high redox stability, and fast response time. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 496–510
Suppressing the environmental dependence of the open‐circuit voltage in inverted polymer solar cells through a radical polymer anodic modifier
Authors: Rostro Lizbeth , Galicia Lucio , Boudouris Bryan W. 
Published: November 2014

ABSTRACTDeveloping stable, readily‐synthesized, and solution‐processable transparent conducting polymers for interfacial modifying layers in organic photovoltaic (OPV) devices has become of great importance. Here, the radical polymer, poly(2,2,6,6‐tetramethylpiperidinyloxy methacrylate (PTMA), is shown to not affect the absorption of the well‐studied poly(3‐hexylthiophene) (P3HT) and [6,6]‐phenyl‐C61‐butyric acid methyl ester (PCBM) active layer when incorporated into inverted OPV devices, as it is highly transparent in the visible spectrum due to the non‐conjugated nature of the PTMA backbone. The inclusion of this radical polymer as an anode‐modifying layer enhanced the open‐circuit voltage and short‐circuit current density values over devices that did not contain an anodic modifier. Importantly, devices fabricated with the PTMA interlayer had performance metrics that were time‐independent over the entire course of multiples days of testing after exposing the OPV devices to ambient conditions. Furthermore, these high performance values were independent of the metal used as the top electrode contact in the inverted OPV devices. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 53, 311–316
Crystal structure of Thermobifida fuscaCse1 reveals target DNA binding site
Authors: Tay Melanie , Liu Su , Yuan Y. Adam 
Published: November 2014

AbstractThe Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)‐CRISPR‐associated (Cas) defense system is the only adaptive and inheritable immunity found in prokaryotes. The immunity is achieved through a multistep process of adaptation, expression, and interference. In the Type I‐E system, interference is mediated by the CRISPR‐associated complex for antiviral defense (Cascade), which recognizes invading double‐stranded DNA (dsDNA) through the protospacer adjacent motif (PAM) by one of the Cascade components, Cse1. Here, we report the crystal structure of Thermobifida fusca Cse1 at 3.3 Å resolution. T. fusca Cse1 reveals the chair‐like two‐domain architecture with a well‐defined flexible loop, L1, located at the larger N‐terminal domain, which was not observed in previous structures of the single Cse1 protein. Structure‐based mutagenesis analysis demonstrates that the well‐defined flexible loop and a partially conserved structural motif ([FW]‐X‐[TH]) are involved in PAM binding and recognition, respectively. Moreover, structural docking of T. fusca Cse1 into Escherichia coli Cascade cryoelectron microscopy maps, coupled with structural comparison, reveals a conserved positive patch that is contiguous with Cse2 in the Cascade complex and adjacent to the Cas3 binding site, suggesting its role in R‐loop formation/stabilization and the recruitment of Cas3 for target cleavage. Consistent with the structural observation, the introduction of alanine mutations at this positive patch abolished DNA binding activity by Cse1. Taken together, these results suggest that Cse1 is a critical Cascade component involved in Cascade assembly, dsDNA target recognition, R‐loop formation, and Cas3 recruitment for target cleavage.
A coordinated multi‐point‐based quality of service provision resource allocation scheme with inter‐cell interference mitigation
Authors: Gong Ming , Ho Pin‐Han , Lin Chih‐Hao 
Published: November 2014

AbstractThe paper investigates resource allocation via power control for inter‐cell interference (ICI) mitigation in an orthogonal frequency division multiple access‐based cellular network. The proposed scheme is featured by a novel subcarrier assignment mechanism at a central controller for ICI, which is further incorporated with an intelligent power control scheme. We formulate the system optimization task into a constrained optimization problem for maximizing accepted users' requirements. To improve the computation efficiency, a fast yet effective heuristic approach is introduced for divide and conquer. Simulation results demonstrate that the proposed resource allocation scheme can significantly improve the network capacity compared with a common approach by frequency reuse. Copyright © 2014 John Wiley & Sons, Ltd.
Cardiac catheterization: consequences for the endothelium and potential for nanomedicine
Authors: Sobolewski Peter , El Fray Miroslawa 
Published: November 2014

Cardiac catheterization results in interactions between the catheter and surfaces and the artery lumen, which is lined by the endothelium. These interactions can range from minor rubbing to severe mechanical injury. Further, in the case of radial access, even atraumatic interactions have consequences ranging from clinical complications, such as radial spasm and radial occlusion, to lasting endothelial cell dysfunction. These consequences may be underappreciated; however, endothelial cells play a central role in maintaining vascular homeostasis via nitric oxide production. Existing treatment paradigms do not address endothelial dysfunction or damage and, thus, novel therapeutic approaches are needed. Nanomedicine, in particular, offers great potential in the form of targeted drug delivery, via functionalized coatings or nanocarriers, aimed at increased nitric oxide bioavailability or reduced inflammation. WIREs Nanomed Nanobiotechnol 2015, 7:458–473. doi: 10.1002/wnan.1316This article is categorized under:

Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease
Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement
Inside single cells: quantitative analysis with advanced optics and nanomaterials
Authors: Cui Yi , Irudayaraj Joseph 
Published: November 2014

Single‐cell explorations offer a unique window to inspect molecules and events relevant to mechanisms and heterogeneity constituting the central dogma of biology. A large number of nucleic acids, proteins, metabolites, and small molecules are involved in determining and fine‐tuning the state and function of a single cell at a given time point. Advanced optical platforms and nanotools provide tremendous opportunities to probe intracellular components with single‐molecule accuracy, as well as promising tools to adjust single‐cell activity. To obtain quantitative information (e.g., molecular quantity, kinetics, and stoichiometry) within an intact cell, achieving the observation with comparable spatiotemporal resolution is a challenge. For single‐cell studies, both the method of detection and the biocompatibility are critical factors as they determine the feasibility, especially when considering live‐cell analysis. Although a considerable proportion of single‐cell methodologies depend on specialized expertise and expensive instruments, it is our expectation that the information content and implication will outweigh the costs given the impact on life science enabled by single‐cell analysis. WIREs Nanomed Nanobiotechnol 2015, 7:387–407. doi: 10.1002/wnan.1321This article is categorized under:

Diagnostic Tools > Biosensing
Nanotechnology Approaches to Biology > Cells at the Nanoscale
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
SrBa2(NH2)6: A New Ternary Amide from Ammonothermal Synthesis
Authors: Hertrampf Jan , Alt Nicolas S. A. , Schlücker Eberhard , Niewa Rainer 
Published: November 2014

AbstractSingle crystals of SrBa2(NH2)6 were obtained from the reaction of barium and strontium metal under ammonothermal conditions at a pressure of 180 MPa and a temperature of 573 K. The crystal structure [a = 6.395(2) Å, b = 7.195(2) Å, c = 10.471(2) Å, β = 97.99(2)°, Z = 2, V = 477.13(2) Å3, P21/n] contains Ba in sevenfold and Sr in octahedral coordination by amide ions, similar to the enviroments of these metal ions in the binary amides. Further, IR and Raman data are reported.
Effects of the Dietary Approach to Stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis
Authors: Siervo Mario , Lara Jose , Chowdhury Shakir , Ashor Ammar , Oggioni Clio , Mathers John C. 
Published: November 2014

The Dietary Approach to Stop Hypertension (DASH) is recommended to lower blood pressure (BP), but its effects on cardiometabolic biomarkers are unclear. A systematic review and meta-analysis of randomised controlled trials (RCT) was conducted to determine the effects of the DASH diet on cardiovascular risk factors. Medline, Embase and Scopus databases were searched from inception to December 2013. Inclusion criteria were as follows: (1) DASH diet; (2) RCT; (3) risk factors including systolic and diastolic BP and glucose, HDL, LDL, TAG and total cholesterol concentrations; (4) control group. Random-effects models were used to determine the pooled effect sizes. Meta-regression analyses were carried out to examine the association between effect sizes, baseline values of the risk factors, BMI, age, quality of trials, salt intake and study duration. A total of twenty articles reporting data for 1917 participants were included in the meta-analysis. The duration of interventions ranged from 2 to 24 weeks. The DASH diet was found to result in significant decreases in systolic BP ( − 5·2 mmHg, 95 % CI − 7·0, − 3·4; P< 0·001) and diastolic BP ( − 2·6 mmHg, 95 % CI − 3·5, − 1·7; P< 0·001) and in the concentrations of total cholesterol ( − 0·20 mmol/l, 95 % CI − 0·31, − 0·10; P< 0·001) and LDL ( − 0·10 mmol/l, 95 % CI − 0·20, − 0·01; P= 0·03). Changes in both systolic and diastolic BP were greater in participants with higher baseline BP or BMI. These changes predicted a reduction of approximately 13 % in the 10-year Framingham risk score for CVD. The DASH diet improved cardiovascular risk factors and appeared to have greater beneficial effects in subjects with an increased cardiometabolic risk. The DASH diet is an effective nutritional strategy to prevent CVD.