bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poorer Right Ventricular Systolic Function and Exercise Capacity in Women After Repair of Tetralogy of Fallot
Authors: Sarikouch Samir , Boethig Dietmar , Peters Brigitte , Kropf Siegfried , Dubowy Karl-Otto , Lange Peter , Kuehne Titus , Haverich Axel , Beerbaum Philipp 
Published: October 2013

Background—
In repaired congenital heart disease, there is increasing evidence of sex differences in cardiac remodeling, but there is a lack of comparable data for specific congenital heart defects such as in repaired tetralogy of Fallot.

Methods and Results—

In a prospective multicenter study, a cohort of 272 contemporary patients (158 men; mean age, 14.3±3.3 years [range, 8–20 years]) with repaired tetralogy of Fallot underwent cardiac magnetic resonance for ventricular function and metabolic exercise testing. All data were transformed to standard deviation scores according to the Lambda–Mu–Sigma method by relating individual values to their respective 50th percentile (standard deviation score, 0) in sex-specific healthy control subjects. No sex differences were observed in age at repair, type of repair conducted, or overall hemodynamic results. Relative to sex-specific controls, repaired tetralogy of Fallot in women had larger right ventricular end-systolic volumes (standard deviation scores: women, 4.35; men, 3.25;
P
=0.001), lower right ventricular ejection fraction (women, −2.83; men, −2.12;
P
=0.011), lower right ventricular muscle mass (women, 1.58; men 2.45;
P
=0.001), poorer peak oxygen uptake (women, −1.65; men, −1.14;
P
<0.001), higher VE/VCO
2
(ventilation per unit of carbon dioxide production) slopes (women, 0.88; men 0.58;
P
=0.012), and reduced peak heart rate (women, −2.16; men −1.74;
P
=0.017). Left ventricular parameters did not differ between sexes.

Conclusions—
Relative to their respective sex-specific healthy control subjects, derived standard deviation scores in repaired tetralogy of Fallot suggest that women perform poorer than men in terms of right ventricular systolic function as tested by cardiac magnetic resonance and exercise capacity. This effect cannot be explained by selection bias. Further outcome data are required from longitudinal cohort studies.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00266188.
Another Stage in the Redactional History of the Bel Story (Dan 14:1-22): The Evidence of Polemic against Foreign Priests and the Focus on Daniel in the Old Greek
Authors: Trotter Jonathan R. 
Published: October 2013

Abstract
It is the contention of this paper that a comparison between the Theodotion and Old Greek versions of the Bel narrative (Dan 14:1-22) gives indications about some specific stages of the textual history of the story. Many of the distinctive elements in the Old Greek story suggest that in its core narrative the Old Greek represents a more thoroughly modified version of the story and even a variant literary edition. In the Old Greek, evidence of the development of the Bel narrative can be seen in its very concentrated focus on (1) the deception of the priests of Bel and (2) the centrality and cunning of Daniel. Both of these emphases in the Old Greek are interconnected and, it will be argued, result in a more pronounced tension between Daniel and the priests of Bel as well as a concentration of control almost exclusively with Daniel in the Old Greek.
Using an AGCM to Diagnose Historical Effective Radiative Forcing and Mechanisms of Recent Decadal Climate Change
Authors: Andrews Timothy 
Published: October 2013

AbstractAn atmospheric general circulation model is forced with observed monthly sea surface temperature and sea ice boundary conditions, as well as forcing agents that vary in time, for the period 1979–2008. The simulations are then repeated with various forcing agents, individually and in combination, fixed at preindustrial levels. The simple experimental design allows the diagnosis of the model’s global and regional time-varying effective radiative forcing from 1979 to 2008 relative to preindustrial levels. Furthermore the design can be used to (i) calculate the atmospheric model’s feedback/sensitivity parameters to observed changes in sea surface temperature and (ii) separate those aspects of climate change that are directly driven by the forcing from those driven by large-scale changes in sea surface temperature. It is shown that the atmospheric response to increased radiative forcing over the last 3 decades has halved the global precipitation response to surface warming. Trends in sea surface temperature and sea ice are found to contribute only ~60% of the global land, Northern Hemisphere, and summer land warming trends. Global effective radiative forcing is ~1.5 W m−2 in this model, with anthropogenic and natural contributions of ~1.3 and ~0.2 W m−2, respectively. Forcing increases by ~0.5 W m−2 decade−1 over the period 1979–2008 or ~0.4 W m−2 decade−1 if years strongly influenced by volcanic forcings—which are nonlinear with time—are excluded from the trend analysis. Aerosol forcing shows little global decadal trend due to offsetting regional trends whereby negative aerosol forcing weakens in Europe and North America but continues to strengthen in Southeast Asia.
3.0T MRI tractography of lumbar nerve roots in disc herniation
Authors: Chuanting Li , Qingzheng Wang , Wenfeng Xiao , Yiyi Hui , Bin Zhao 
Published: October 2013

Background Diffusion tensor imaging (DTI) with fiber tracking (FT) has found clinical applications in the evaluation of the central nervous system and has been extensively used to image white matter tract. The feasibility of FT of the lumbar nerve roots in disc herniation is unclear. Purpose To demonstrate the feasibility of FT in the lumbar nerve roots, and to assess potential differences in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of L4, L5, and S1 nerves between healthy disc and disc herniation. Material and Methods Twenty patients with unilateral sciatica related to posterolateral or foraminal disc herniation and 20 healthy volunteers were enrolled in our study. Anatomical fusion with the axial T2 sequences was used to estimate the relevance of reconstructions. DTI with tractography of the L4, L5, and S1 nerves was performed. Mean FA and ADC values were calculated from tractography images. Results Lumbosacral root compression sites could be clearly identified on the tractography images. There was no significant difference in FA or ADC between left and right nerve roots at the same level ( P > 0.05) in healthy volunteers. The mean FA value of the compressed spinal nerve roots was significantly lower than that of FA of the contralateral nerve roots ( P = 0.0001). ADC was significantly higher in compressed nerve roots than that in the contralateral nerve root ( P = 0.0002). Conclusion 3 T magnetic resonance imaging (MRI) DTI and FT of the lumbosacral region nerve is possible. There are significant changes in FA and ADC values in the compressed L4, L5, and S1 nerves.
Common cerebral networks associated with distinct deep brain stimulation targets for cluster headache
Authors: Clelland Claire D , Zheng Zhong , Kim Won , Bari Ausaf , Pouratian Nader 
Published: October 2013

Background Several centers have reported efficacious cluster headache suppression with deep brain stimulation (DBS) of the hypothalamic region using a variety of targets. While the connectivity of some of these targets has individually been studied, commonalities across these targets, especially with respect to network-level connectivity, have not previously been explored. Methods We examined the anatomic connectivity of the four distinct DBS targets reported in the literature using probabilistic diffusion tensor tractography in normal subjects. Results Despite being described as hypothalamic, the DBS targets localized in the midbrain tegmentum posterior to the hypothalamus. Common tracts across DBS targets and subjects included projections to the ipsilateral hypothalamus, reticular formation, and cerebellum. Discussion Although DBS target coordinates are not located within the hypothalamus, a strong connection between DBS targets and the hypothalamus likely exists. Moreover, a common projection to the medial ipsilateral cerebellum was identified. Understanding the common connectivity of DBS-targeted regions may elucidate anatomic pathways that are involved in modulating cluster headache attacks and facilitate more precise patient-specific targeting of DBS.
Pharmacological Management of the Obese Patient
Authors: Schumacher Donald 
Published: October 2013

Being obese goes beyond moral failure or a character flaw. Obesity has the defining characteristics of a chronic disease for which there is no cure. Treatment may require lifelong treatment which may include pharmacotherapy. Experience with long term use of obesity drugs is limited but evidence suggests that pharmacotherapy can improve patient outcomes and patient outlook. With current obesity drugs, weight loss is usually modest but clinically significant satisfying the FDA threshold for drug effectiveness. This weight loss is associated with clinically significant improvements in many obesity co morbidities and risk factors and could eliminate some risk factors with continued use. When used in conjunction with a comprehensive program for weight management, obesity drugs can reduce appetite or hunger, increase satiety, provide improved control over aberrant eating behaviors and modify food seeking behaviors. Pharmacotherapy can enhance weight loss and compliance during the periods of weight loss and in maintaining that weight loss, increasing physical activity and may enhance a focus on making life long changes. This article will discuss mechanisms of action of obesity drugs, theories of altered body defense of body weight, Food and Drug Administration (FDA) approved obesity drugs, and off-label use of FDA approved drugs. The value of over-the counter (OTC) medications and diet supplements, as well as fat substitutes in the treatment of obesity drugs will be explored. Obesity drugs awaiting FDA approval and compounds under development will be reviewed. The section on approaches to drug management will include clinical considerations for; who should receive pharmacotherapy and when, length of treatment and drug discontinuation, weight regain and the role of pharmacotherapy.
Health in arts: are arts settings better than sports settings for promoting anti-smoking messages?
Authors: Davies Christina , Knuiman Matthew , Pikora Terri , Rosenberg Michael 
Published: October 2013

Aim: Tobacco smoking is a leading cause of preventable mortality and morbidity. Since 1991, the Western Australian Health Promotion Foundation (Healthway) has sponsored the arts and sport in exchange for cigarette smoke-free events, smoke-free policies and the promotion of anti-smoking messages (e.g. Quit, Smoke Free or Smarter than Smoking). As health promoters often look for innovative and effective settings to advocate health, and as the approach of sponsoring the arts to promote health to the general population is uncommon, the purpose of this study was to evaluate the effectiveness of ‘health in arts’ by measuring the cognitive impact (message awareness, comprehension, acceptance and intention) of promoting anti-smoking messages at arts events, and comparing findings to sports events, a more traditional health promotion setting. Method: A secondary analysis of the 2004–2009 Healthway Sponsorship Monitor data was conducted. A total of 12 arts events ( n = 592 respondents) and 9 sports events ( n = 420 respondents) sponsored by Healthway to promote an anti-smoking message were evaluated. The study was cross-sectional in design. Participants were residents of Western Australia aged 15 years or above and attended events as part of an audience or as a spectator. Descriptive and regression analyses were conducted. Results: After adjustment for demographic variables, smoking status and clustering, arts events were found to be as effective in promoting anti-smoking message awareness, comprehension and acceptance and twice as effective on intention to act ( p = .03) compared with sports events. Conclusion: This study provides evidence of the effectiveness of arts sponsorship to promote health to the general population, that is, health in arts. Promoting an anti-smoking message in arts settings was as, or more, effective than in sports settings. Results suggest that the arts should be utilised to communicate and reinforce anti-smoking messages to the general population. The suitability of the arts to promote other types of health messages should be investigated further.
Influence of losartan on the hypoglycemic activity of glimepiride in normal and diabetic rats
Authors: Murthy T.E.G.K. , Kommineni Manogna K. , Mayuren Candasamy 
Published: October 2013

Background: The influence of losartan on the hypoglycemic effect of glimepiride was studied in normal and diabetic rats. Method: Losartan and glimepiride were studied at a dose of 4.5 and 0.09 mg/kg and in normal and diabetic rats, respectively. The blood samples were collected at 0, 1, 2, 3, 4, 6, 8, 10, 12, and 16 hours and analyzed for glucose levels using a glucometer. Results: Glimepiride exhibited a maximum reduction of blood glucose levels at the 4th hour in normal and diabetic rats. The maximum hypoglycemic effect was observed at the 6th hour in normal rats treated with losartan. In normal rats, losartan did not have any significant effect on the hypoglycemic activity of glimepiride in either the single- or multiple-dose interaction study. In the case of diabetic rats, losartan did not have any significant effect on the hypoglycemic activity of glimepiride in the single-dose interaction study, but a significant change was observed in the multiple-dose study of diabetic rats. Hence, the interaction was found to be pharmacodynamic. Conclusions: The study indicates that chronic losartan pretreatment elevates the hypoglycemic effect of glimepiride by a possible rise in insulin sensitivity and improving insulin homeostasis or may be due to the inhibition of CYP2C9. The study also suggests that caution may be recommended concerning combined use of losartan and an oral hypoglycemic agent, glimepiride.
The genetic basis of myelodysplasia and its clinical relevance
Authors: Cazzola Mario , Della Porta Matteo G. , Malcovati Luca 
Published: October 2013

Abstract
Myelodysplasia is a diagnostic feature of myelodysplastic syndromes (MDSs) but is also found in other myeloid neoplasms. Its molecular basis has been recently elucidated by means of massive parallel sequencing studies. About 90% of MDS patients carry ≥1 oncogenic mutations, and two thirds of them are found in individuals with a normal karyotype. Driver mutant genes include those of RNA splicing (SF3B1, SRSF2, U2AF1, and ZRSR2), DNA methylation (TET2, DNMT3A, and IDH1/2), chromatin modification (ASXL1 and EZH2), transcription regulation (RUNX1), DNA repair (TP53), signal transduction (CBL, NRAS, and KRAS), and cohesin complex (STAG2). Only 4 to 6 genes are consistently mutated in ≥10% MDS patients, whereas a long tail of ∼50 genes are mutated less frequently. At presentation, most patients typically have 2 or 3 driver oncogenic mutations and hundreds of background mutations. MDS driver genes are also frequently mutated in other myeloid neoplasms. Reliable genotype/phenotype relationships include the association of the SF3B1 mutation with refractory anemia with ring sideroblasts, TET2/SRSF2 comutation with chronic myelomonocytic leukemia, and activating CSF3R mutation with chronic neutrophilic leukemia. Although both founding and subclonal driver mutations have been shown to have prognostic significance, prospective clinical trials that include the molecular characterization of the patient’s genome are now needed.
Conditional over-expression of RAGE by embryonic alveolar epithelium compromises the respiratory membrane and impairs endothelial cell differentiation
Authors: Winden Duane R , Ferguson Nicholas T , Bukey Benjamin R , Geyer Alexander J , Wright Alex J , Jergensen Zac R , Robinson Adam B , Stogsdill Jeffrey A , Reynolds Paul R 
Published: October 2013

Abstract

Background
Receptors for advanced glycation end-products (RAGE) are cell surface receptors prominently expressed by lung epithelium. Previous research demonstrated that over-expression of RAGE by murine alveolar epithelial cells during embryogenesis caused severe lung hypoplasia and neonatal lethality. However, the effects of RAGE over-expression on adjacent matrix and endothelial cells remained unknown.

Methods
RAGE transgenic (TG) mice were generated that conditionally over-expressed RAGE in alveolar type II cells when fed doxycycline (dox) from conception to E18.5. To evaluate effects on the basement membrane, immunostaining and immunoblotting were performed for collagen IV and MMP-9, a matrix metalloprotease capable of degrading basement membranes. To assess changes in vasculature, immunostaining, immunoblotting and qRT-PCR were performed for Pecam-1, a platelet endothelial cell adhesion marker also known as CD31. Lastly, to characterize potential regulatory mechanisms of endothelial cell differentiation, immunoblotting and qRT-PCR for FoxM1, a key endothelium-specific transcription factor of the Forkhead Box (Fox) family, were completed.

Results
Qualitative immunostaining for collagen IV was less in RAGE TG mice compared to controls and immunoblotting revealed decreased collagen IV in the RAGE TG mouse lung. Additionally, elevated MMP-9 detected via immunostaining and immunoblotting implicated MMP-9 as a possible down stream effector in matrix destabilization mediated by RAGE signaling. Lastly, Pecam-1 assessment revealed a decrease in the prevalence of microvascular endothelial cells coincident with FoxM1 abrogation in RAGE TG mice compared to controls.

Conclusions
RAGE over-expression by alveolar epithelium weakened the basement membrane and associated matrix via increased MMP-9 activity. Furthermore, over-expression of RAGE inhibited FoxM1, suggesting that anomalous transcriptional control contributes to decreased endothelial cell prevalence in the TG mouse lung.
Partner support in a cohort of African American families and its influence on pregnancy outcomes and prenatal health behaviors
Authors: Straughen Jennifer K , Caldwell Cleopatra H , Young Alford A , Misra Dawn P 
Published: October 2013

Abstract

Background
We examined how two indicators of partner involvement, relationship type and paternal support, influenced the risk of pregnancy outcomes (preterm birth, low birth weight) and health behaviors (prenatal care, drug use, and smoking) among African American women.

Methods
Interview and medical record data were obtained from a study of 713 adult African American women delivering singletons between March 2001 and July 2004. Women were enrolled prenatally if they received care at one of three Johns Hopkins Medical Institution (JHMI) prenatal clinics or post-partum if they delivered at JHMI with late, no or intermittent prenatal care. Relationship type was classified as married, unmarried/cohabitating, or unmarried/non-cohabitating. Partner support was assessed using an 8-item scale and was dichotomized at the median. Differences in partner support by pregnancy outcome and health behaviors were assessed using linear regression. To assess measures of partner support as predictors of adverse pregnancy outcomes and health behaviors, Poisson regression was used to generate crude and adjusted prevalence ratios (PR) and 95% confidence intervals (CI).

Results
There were no statistically significant differences in pregnancy outcomes or health behaviors by relationship type or when partner support was examined as a continuous or categorical variable. Modeled as a dichotomous variable, partner support was not associated with the risk of preterm birth (PR = 0.81, 95% CI = 0.56, 1.56), low birth weight (PR = 0.77, 96% CI = 0.48, 1.26), or health behaviors.

Conclusions
Paternal involvement was not associated with pregnancy outcomes or maternal health behaviors. Attention to measurement issues and other factors relevant for African American women are discussed.
Independent associations of socioeconomic factors with disability and pain in adults with knee osteoarthritis
Authors: Cleveland Rebecca J , Luong My-Linh N , Knight Joshua B , Schoster Britta , Renner Jordan B , Jordan Joanne M , Callahan Leigh F 
Published: October 2013

Abstract

Background
The purpose of this study is to explore the relationship between function, pain and stiffness outcomes with individual and community socioeconomic status (SES) measures among individuals with radiographic knee osteoarthritis (rOA).

Methods
Cross-sectional data from the Johnston County Osteoarthritis Project were analyzed for adults age 45 and older with knee rOA (n = 782) and a subset with both radiographic and symptomatic knee OA (n = 471). Function, pain and stiffness were measured using the Western Ontario and McMasters Universities Index of Osteoarthritis (WOMAC). Individual SES measures included educational attainment (<12 years, ≥12 years) and occupation type (managerial, non-managerial), while community SES was measured using Census block group poverty rate (<12%, 12-25%, ≥25%). SES measures were individually and simultaneously examined in linear regression models adjusting for age, gender, race, body mass index (BMI), occupational physical activity score (PAS), comorbidity count, and presence of hip symptoms.

Results
In analyses among all individuals with rOA, models which included individual SES measures were observed to show that occupation was significantly associated with WOMAC Function (β =2.91, 95% Confidence Interval (CI) = 0.68-5.14), WOMAC Pain (β =0.93, 95% CI = 0.26-1.59) and WOMAC Total scores (β =4.05, 95% CI = 1.04-7.05), and education was significantly associated with WOMAC Function (β =3.57, 95% CI = 1.25-5.90) and WOMAC Total (β =4.56, 95% CI = 1.41-7.70) scores. In multivariable models including all SES measures simultaneously, most associations were attenuated. However, statistically significant results for education remained between WOMAC Function (β =2.83, 95% CI = 0.38-5.28) and WOMAC Total (β =3.48, 95% CI = 0.18-6.78), as well as for the association between occupation and WOMAC Pain (β =0.78, 95% CI = 0.08-1.48). In rOA subgroup analyses restricted to those with symptoms, we observed a significant increase in WOMAC Pain (β =1.36, 95% CI = 0.07-2.66) among individuals living in a block group with poverty rates greater than 25%, an association that remained when all SES measures were considered simultaneously (β =1.35, 95% CI = 0.06-2.64).

Conclusions
Lower individual and community SES are both associated with worse function and pain among adults with knee rOA.