Brazilian consensus recommendations on the diagnosis and treatment of autoimmune encephalitis in the adult and pediatric populations
Authors: Dutra Lívia Almeida , Silva Pedro Victor de Castro , Ferreira João Henrique Fregadolli , Marques Alexandre Coelho , Toso Fabio Fieni , Vasconcelos Claudia Cristina Ferreira , Brum Doralina Guimarães , Pereira Samira Luisa dos Apóstolos , Adoni Tarso , Rocha Leticia Januzi de Almeida , Sampaio Leticia Pereira de Brito , Sousa Nise Alessandra de Carvalho , Paolilo Renata Barbosa , Pizzol Angélica Dal , Costa Bruna Klein da , Disserol Caio César Diniz , Pupe Camila , Valle Daniel Almeida do , Diniz Denise Sisterolli , Abrantes Fabiano Ferreira de , Schmidt Felipe da Rocha , Cendes Fernando , Oliveira Francisco Tomaz Meneses de , Martins Gabriela Joca , Silva Guilherme Diogo , Lin Katia , Pinto Lécio Figueira , Santos Mara Lúcia Schimtz Ferreira , Gonçalves Marcus Vinícius Magno , Krueger Mariana Braatz , Haziot Michel Elyas Jung , Barsottini Orlando Graziani Povoas , Nascimento Osvaldo José Moreira do , Nóbrega Paulo Ribeiro , Proveti Priscilla Mara , Castilhos Raphael Machado do , Daccach Vanessa , Glehn Felipe von 
Published: August 2024

Abstract
Background Autoimmune encephalitis (AIE) is a group of inflammatory diseases characterized by the presence of antibodies against neuronal and glial antigens, leading to subacute psychiatric symptoms, memory complaints, and movement disorders. The patients are predominantly young, and delays in treatment are associated with worse prognosis.
Objective With the support of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN) and the Brazilian Society of Child Neurology (Sociedade Brasileira de Neurologia Infantil, SBNI), a consensus on the diagnosis and treatment of AIE in Brazil was developed using the Delphi method.
Methods A total of 25 panelists, including adult and child neurologists, participated in the study.
Results The panelists agreed that patients fulfilling criteria for possible AIE should be screened for antineuronal antibodies in the serum and cerebrospinal fluid (CSF) using the tissue-based assay (TBA) and cell-based assay (CBA) techniques. Children should also be screened for anti-myelin oligodendrocyte glucoprotein antibodies (anti-MOG). Treatment should be started within the first 4 weeks of symptoms. The first-line option is methylprednisolone plus intravenous immunoglobulin (IVIG) or plasmapheresis, the second-line includes rituximab and/or cyclophosphamide, while third-line treatment options are bortezomib and tocilizumab. Most seizures in AIE are symptomatic, and antiseizure medications may be weaned after the acute stage. In anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the panelists have agreed that oral immunosuppressant agents should not be used. Patients should be evaluated at the acute and postacute stages using functional and cognitive scales, such as the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Modified Rankin Scale (mRS), and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE).
Conclusion The present study provides tangible evidence for the effective management of AIE patients within the Brazilian healthcare system.