bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon / Sila-Pharmaca, 31 th Communication [1] Synthesis, Structure, and Pharmacological Properties of Diphenyl(2-piperidinoethoxymethyl)silanol and its Carbon Analogue
Authors: Tacke Reinhold , Lange Hartwig , Sheldrick William S. , Lambrecht Günter , Moser Ulrich , Mutschier Ernst 
Published: February 2015

Abstract
In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).
Koordinationschemie funktioneller Phosphorylide, V [1] Die Molekülstrukturen der isomorphen Mangan-und Rheniumbromtricarbonyl- komplexe von 2-Methyl-2-(triphenylphosphonio)dithiopropionat / Coordination Chemistry of Functional Phosphorus Ylides, V [1] The Molecular Structures of the Isomorphous Manganese and Rhenium Bromotricarbonyl Complexes of 2-Methyl-2-(triphenylphosphonio)dithiopropionate
Authors: Winter Werner , Merkel Reinhard , Kunze Udo 
Published: February 2015

Abstract
The isomorphous crystal structures of the manganese and rhenium bromotricarbonyl complexes 2 a, b have been determined at room temperature (Mn) and at -110 °C (Mn, Re; P21/c, Z - 4). At room temperature, data collection is accompanied by crystal decomposi-tion, and a cleavage of the PPh3 group is suggested by the results as the primary process. The same initial step is thought to be valid for the photodecomposition in solution. The main structural difference between the free and coordinated betaine ligand 1 is the reduced electrostatic interaction of P and S in the complexed form.
Preparation and Stereochemistry of 12a-Hydroxymethyl Derivatives of Rotenone and Amorphigenin
Authors: Kostova I. , Ognyanov I. 
Published: February 2015

Abstract
A convenient method for the preparation of 12a-hydroxymethyl derivatives of rotenone 1 and amorphigenin 2, possibly applicable to other rotenoids with activated 12a-hydrogen atom is described. The stereochemistry of the products is discussed.
"Ag8SnTe6" — Ein neuer stabiler Vertreter der Argyrodite ? "Ag8SnTe6" -a New Stable Argyrodite ?
Authors: Gather Bernd , Blachnik Roger 
Published: February 2015

Abstract
DTA, X-ray and microprobe measurements show, that the compound "Ag8SnTe6" seems not to be a stable argyrodite.
Bindungsverhältnisse und magnetische Eigenschaften ternärer Arsenide ET2As2 / Bonding and Magnetic Properties in Ternary Arsenides ET2As2
Authors: Pfisterer Martin , Nagorsen Günter 
Published: February 2015

Abstract
The interatomic distances of ternary arsenides ET2As2 with ThCr2Si2-structure were determined by X-ray powder methods (E = Ca, Sr, Ba; T = Cr, Fe, Co, Ni, Cu). The phases were found to behave according to the Zintl-Klemm-Busmann concept. Magnetic susceptibilities were measured.
Aktivierung von CO2 an Übergangsmetallzentren: Struktur und Reaktivität eines C-C-Kopplungsproduktes von CO2 und 2.3-Dimethylbutadien am elektronenreichen Nickel(O) / Activation of CO2 at Transition Metal Centers: Structure and Reactivity of a C-C-Coupling Product of CO2 and 2,3-Dimethylbutadiene at Electron-Rich Nickel(O)
Authors: Walther Dirk , Dinjus Eckhard , Sieler Joachim , Thanh Nguyen Ngoc , Schade Wolfgang , Leban Ivan 
Published: February 2015

Carbon dioxide reacts with 2,3-dimethylbutadiene and bis-cyclooctadiene(1,5)-nickel(O) in the presence of N,N′-tetramethyl-ethylendiamine (tmeda) to form [(3,4,5-η3)-3,4-dimethyl-3-pentenylato](N,N′-tetramethyl-ethylendiamine)-nickel(II) as the product of the oxidative coupling of CO2 and the diene. The deep red complex crystallizes in the rhombic space group Pbca. The structure was determined by an X-ray analysis. The monodendate carboxylate group, the π-allyl system and a N-atom of tmeda form a planar coordination sphere around the central atom. The distance between Ni and the second N-atom of tmeda is very long (2.314 Å).
Reaction of the complex with R−X (R: H, CH3) yield 3-unsaturated carboxylic acids; tmeda can be substituted by 2,2′-bipyridine.
Photochemische Reaktionen von Übergangsmetall-Olefin-Komplexen, VII [1] Die Reaktion von Triearbonyl-η6-cyclooctatetraen-chrom(0) mit 6-mono-und 6.6-disubstituierten Fulvenen / Photochemical Reactions of Transition Metal Olefin Complexes, VII [1] The Reactions of Tricarbonyl-η6-cyclooctatetraene-chromium(0) with 6-Mono-and 6,6-Disubstituted Fulvenes
Authors: Kreiter Cornelius G. , Kurz Hans 
Published: February 2015

Tricarbonyl-η6-cyclooctatetraene-chromium(0) (1) reacts photochemically with 6-mono- and 6,6-disubstituted fulvenes (2-7) in a substitution-oxidative rearrangement-reaction to dicarbonyl-η-1′-3':1″-5″-(cycloocta-2′,4′,6′-trien-1′,8′-ylene-cyclopentadienylidene-methane)chromium complexes (8−13). Tricarbonyl-η-6,6-dimethylfulvene-chromium(0) (16) reacts with cyclooctatetraene, bicyclo[6,1,0]nona-2,4,6-triene and anti-9-methoxybicyclo-[6,1,0]nona-2,4,6-triene in a similar manner and forms 8 and 2-bicyclo[6,1,0]nona-4′,6′-dien-2′,3′-ylene-2-cyclopentadienylidene-propane complexes (19, 20). In addition to 13 6-dimethylaminofulvene (7) yields with 1 dicarbonyl-η-1′,6′,7′: 1″-5″-(2-cyclohepta-2′,4′,6′-trien-7′-ylidene-1 -cyclopentadienylidene-1-dimethylamino-ethane)-chromium (14) which involves an unexpected contraction of the eight-membered ring. The constitutions of 8−15 and 19−20 were determined by IR and NMR spectroscopy.
In Cr(CO)2[C(C6H5)2(C5H4)(C8H8)] (9) one of the phenyl groups shows hindered rotation around its two fold axis.
Quantum Chemical Interpretation of the Photoinitiated Autoxidation of Sulphite Catalysed by Ferric Ions
Authors: El-Wakil A. M. , Soliman M. S. , Farag A. B. 
Published: February 2015

Abstract
Autoxidation of sulphite is the first well known chain reaction proceeding through free radicals in solutions. Dark and photochemical autoxidation of sulphite were stated to take place by the same mechanism except in the initial steps. It was found that the formation of sulphite radicals in photoinitiated autoxidation of sulphite which is a metal catalysed reaction as well as the classical thermal reaction is due to the absorption of photons by ferrisulphite complexes rather than sulphite itself. Confirmation of this finding was achieved spectrophotometrically as well as by the fact that such complexes are specified by very high stability constants. The present work is a further evidence for the presence of such complexes and to cover the gap present before in the literature data. Quantum mechanical calculations using the extended Hückel molecular orbital method has proved that the range of absorption by sulphite lies in a region at which sulphite alone does absorb at all, and the absorption process is thus due to the formation of ferrisulphite complexes.
Untersuchungen an quartären Pyridinium-Salzen, XV [1] Pseudobasen und Redoxprodukte bei der Umsetzung von Pyridinium-Salzen mit Alkoholat / Investigations of Quaternary Pyridinium Salts, XV [1] Pseudobases and Redox Products in the Reaction of Pyridinium Salts with Alcoxides
Authors: Gündel Wolf-H. 
Published: February 2015

Abstract
Mono-and diquaternary pyridinium salts substituted in 3-position with electron with-drawing groups, react with alcohols under basic conditions to give 6-alcoxy-1,6-dihydro-pyridines. Symmetric dipyridinium salts react in aqueous alkaline solution to products with 6-pyridone and dihydropyridine moiety. This redox reaction depends on the length of the bridge connecting the pyridinium rings. Pyridinium salts can be reduced by aluminiumtriisopropoxide to 1,4-dihydropyridines.
Notizen: Einkristall-Daten der Hochdruck- Hochtemperaturphase von SrSi2 / Single Crystal Data of the High Pressure-High Temperature Phase of SrSi2
Authors: Evers Jürgen , Oehlinger Gilbert , Weiss Armin 
Published: February 2015

Abstract
The high pressure-high temperature phase of SrSi2 is a stoichiometric representative of the a-ThSi2 type of structure. A single crystal investigation leads to interatomic distances Si-Si: 233.0(2) pm (1 x) and 248.9(2) pm (2 x), Sr-Si: 319.1(4) pm (4 x) and 334.7(4) pm (8 x), Sr-Sr: 410.8(3) pm (4 x) and 443.8(3) pm (4 x).
Ringförmige [(GeTe2)4Te2]8- -Anionen im Na8Ge4Te10(II) / Cyclic [(GeTe2)4Te2]8- -Anions in Na8Ge4Te10(II)
Authors: Eisenmann Brigitte , Schäfer Herbert , Schwerer Heike 
Published: February 2015

Na8Ge4Te10 exists in two modifications I and II, of which structure I was determined previous by [3]. Modification II crystallizes in the triclinic system, space group P1̄ with the lattice constants:
a = 1070.1(5) pm, b = 963.9(5) pm, c = 792.3(4) pm
α = 67.9(1)°, β = 70.7(1)°, γ = 68.3(1)°.
In the structure there are [Ge4Te10]8- anions in the form of six-membered rings [(GeTe2)4Te2]8-.
Übergangsmetall-Komplexe mit Schwefelliganden, V. Synthese, Reaktivität und Struktur von Carbonyl-, Phosphin-und Hydrazin- Eisen(II)-Komplexen mit zwei- und vierzähnigen Schwefelliganden / Transition Metal Complexes with Sulfur Ligands, V. Synthesis, Reactivity and Structure of Carbonyl-, Phosphine-, and Hvdrazin-Iron(II). Complexes with Two-and Fourdentate Sulfur Ligands
Authors: Sellmanir Dieter , Lanzrath Günther , Hüttner Gottfried , Zsolnai Laszlo , Krüger Carl , Claus K. H. 
Published: February 2015

Reaction of FeCl3 · 4 H2O with dttd2-, the dianion of 2,3,8,9-dibenzo-1.4,7,10-tetru-thiadecane, leads to the solvated [Fe(dttd)], which coordinates CO, PMe3 and N3H4 yielding [Fe(CO)2dttd], [Fe(PMe3)2dttd], [Fe(CO)PMe3(dttd)], [Fe(N2H4)2dttd] and [Fe(N2H4)CO(dttd), respectively. With H2S and [Fe(dttd)] the Fe(III) complex (PPN)2[Fe2(S)2(dttd)2] is obtained. PPh3 cannot be coordinated to [Fe(dttd)], whereas the reaction between [Fe(PPh3)(CO)3I2] and LiSC6H4SCH3yields [Fe(PPh3)CO(CH3SCeH4S)2] besides the major product [Fe(CO)2(CH3SCeH4S)2]. A PPh3 complex can be obtained also with o-benzenedithiolate, C6H4S2
2-: Reacting [Fe(PPh3)(CO)3I3] with Li2S2C6H4 yields the binuclear [Fe(PPh3)(CO)2C6H4S2]2. Oxidation of [Fe(N3H4)CO(dttd)] by various agents leads to [Fo(CO)dttd]2 without evidence of formation of a N2 complex intermediate. Nucleophilic attack of [Fe(CO)2(CH3SC6H4S)2] by lithium organyls as e.g. LiPh leads to the benzoylato complex [Li(THF)3][Fe(CO)(PhCO)(CH3SC6H4S)2]; the structures of the starting complex as well as of the adduct have been elucidated by X-ray structure determination. Nucleophilic attack of the corresponding [Fe(CO)2dttd] by LiPh occurs reversibly at the Fe center; by cleavage of a Fe-S bond [Fe(Ph)(CO)2dttd′]- is formed, where dttd′ is acting as a tridentate ligand. This result shows how the reactions of formally equivalent complexes like [Fe(CO)2(CH3SC6H4S)2] and [Fe(CO)2dttd] depend strongly upon the denticity of the sulfur ligands. The dependence upon the character of the nucleophilic agent is shown by the reaction of [Fe(CO)2dttd] with Li[BEt3H]; in this case again a CO ligand is attacked reversibly yielding the formyl complex [LiBEt3][Fe(HCO)CO(dttd)], the structure of which could be elucidated so far only spectroscopically as well as by elemental analysis.
[Fe(Ph)(CO)gdttd′]- forms salts like e.g. (AsPh4)[Fe(Ph)(CO)2dttd]; in solution they slowly loose CO yielding e.g. binuclear (AsPh4)2[Fe(Ph)dttd]3. Attempts to isolate the anion as [Li(TMED)3]+ salt load to the loss of CO as well as of phenyl ligands yielding the paramagnetic [Fe(TMED)dttd], which is also obtained directly from [Fe(dttd)] and TMED. The phenyl complex [Fe(Ph)dttd]2
2- is also formed by reaction of [Fe(dttd)] with LiPh; on reaction with dimethyl-formamide it yields [Fe(DMF)dttd]2. A series of the above described compounds has been investigated by Mößbauer spectroscopy.
Über Naphtho[1.8-de]-1,3-dioxine / Naphtho[1,8-de]-1,3-dioxines
Authors: Daliacker Franz , Jacobs Johannes , Coerver Wim 
Published: February 2015

Treatment of 1,8-Dihydroxy-naphthaline with bromochloromethane/K3CO3 in DMF gives Naphtho[1,8-de]-1,3-dioxine (1a) in good yield. The bromo (1b) and nitro compound (1c) can be obtained free of isomorics by electrophilic substitution of la. Bromolithium exchange of 1b leads to a lithium organic compound, which possibles the synthesis of alkyl-, olefinic-, and carboxylic derivatives of the substrate 1a.
In a similar way the treatment of 2,3-dihydroxynaphthazarin with chlorobromomethane/K2CO3 gives the naphtho[1,8-de;4,5-d′e′]-bis-1,3-dioxine (3a). The substrate 3a can be subjected to electrophilic aromatic substitutions.
Fluorapatit Ca5F(PO4)3 - Ein Modell zur Synthese der Zahnhartsubstanz im System CaF2-Ca3(PO4)2 / Fluorapatite - A Model for the Synthesis of Dental Enamel in the System CaF2-Ca3(PO4)2
Authors: Franz Ernst-Dieter 
Published: February 2015

Abstract
Fluorapatite Ca5F(PO4)3 can be synthesized by melting of CaF2 together with Ca3(PO4)2 at 1660 °C in the molar ratio CaF2 · 3 Ca3(PO4)2. Fluorapatite is more resistant against acids than hydroxylapatite Ca5OH(PO4)2 and can activate the remineralisation in dental enamel. The apatite of dental enamel is more resistant against mechanical stress than synthetic apatite due to a different microstructure of the crystal grains.
Tetrathio -spiro -phosphonia -tetrachloroborateDie Struktur von 1.4.6.9-Tetrathio-5-phosphonia-spiro (4.4) nonan-tetrachloroborat / Tetrahio-spiro-phosphonia TetrachloroboratesThe X-Ray Crystal Structure of 1,4,6,9-Tetrahio-5-phosphonia-spiro(4,4)nonan Tetrachloroborate
Authors: Koblischek Alfred , Hausen Hans-Dieter , Weidlein Johann , Binder Herbert 
Published: February 2015

Abstract
A series of tetrathio-spiro-phosphonia tetrachloroborates have been synthesized by the reaction of PCl4+BCl4
- with 1,2-ethane-, 1,2-propane-and 1,3-propane dithiole. The crystal structure of 1,4,6,9-tetrathio-5-phosphonia-spiro(4,4)nonane tetrachloroborate, 3a, was determined from diffractometer data and refined to R = 0.056 for 4003 independent reflexions. 3a, orthorhombic, Pbcn, a = 1493.0(3), b = 1515.6(3), c = 1213.3(4) pm. The unit cell containes eight formula units.
Cyclische Diazastannylene, XVIII [1]Zur Frage der Bindungsbeschreibung in Polyedern des Typs Sn4X3Y:Die Kristall-und Molekülstrukturen von Sn4(NtBu)4 und Sn4(NtBu)3O / Cyclic Diazastannylenes, XVIII [1]Bonding Description in Polyhedra of the Sn4X3Y-Type:The Crystal and Molecular Structures of Sn4(NtBu)4 and Sn4(NtBu)3O
Authors: Veith M. , Recktenwald O. 
Published: February 2015

Abstract
Crystals of Sn4(NtBu)4 (1) are monoclinic, space group P21/c, with cell constants a = 1038.9(4), b = 1468.3(5), c = 1698.8(5) pm, β = 91.6(1)° and Z = 4, while those of Sn4(NtBu)3O (2) are triclinic, space group P 1̄, with dimensions a = 1293.0(5), b = 1027.1(5), c = 1716.7(9) pm, α = 90.9(1), β = 102.5(1), γ = 107.0(1)° and Z = 4. The molecules 1 are held together by van-der-Waals forces, whereas two molecules 2 interact in the crystal by weak 0→Sn donor bonds (290-332 pm) forming dimers. The outstanding structural elements of 1 and 2 are the Sn4N4 and Sn4N3O polyhedra, which can be described by two interpenetrating tetrahedra of tin atoms and of nitrogen or nitrogen and oxygen atoms forming a distorted cube, which approaches 4̄3 m symmetry in the case of 1 and 3m for 2. Characteristic distances are in 1: Sn-N 220.2 pm, in 2: Sn-N 221.3 pm and Sn-O 213.2 pm. An almost ionic bonding model and two covalent models are discussed on the basis of the structural data including Sn4(NtBu)3OAlMe3.
Siliciumverbindungen mit starken intramolekularen sterischen Wechselwirkungen, XIV [1] Versuche zur Synthese des Tetra-tert-butylsilans: Tri-tert-butylisopropylsilan und verwandte Verbindungen / Silicon Compounds with Strong Intramolecular Steric Interactions, XIV [1] Attempted Synthesis of Tetra-tert-butylsilane: Tri-tert-butylisopropylsilane and Related Compounds
Authors: Weidenbruch Manfred , Flott Hermann , Ralle Bernd , Peters Karl , Schnering Hans Georg von 
Published: February 2015

Abstract
Reaction of tri-tert-butyl(dihalomethyl)silanes (halo = chloro, bromo) with organolithium compounds, by lithium/halogen or lithium/hydrogen exchange, leads to the corresponding carbenoids which by lithium halide elimination could give the carbenes (t-C4H9)3SiCX. Further intermolecular or intramolecular reaction of these reactive intermediates provides a variety of crowded molecules including alkyltri-tert-butylsilanes, 1,2-bis(tri-tert-butylsilyl)- substituted ethanes and ethenes and ring substituted 1,2-di-tert-butyl-1-silacyclo-butanes. An X-ray structure determination of (E)-1,2-bis(tri-tert-butylsilyl)-1,2-dichloroethene reveals neither a twisting nor an elongation of the CC double bond, but the C = C-Si bond angles exhibit rather unusual values (up to 137.7°) and the Si-C (sp2) bonds are as long as 195 pm.
Tri-tert-butylisopropylsilane was prepared by a two step procedure and characterized by its variable temperature NMR spectra. The attempted synthesis of tetra-tert-butylsilane by reactions of the compound with bromine followed by treatment with methyllithium afforded only tri-tert-butylisopropenylsilane.
A New Synthesis of Organodifluorophosphites and their Reactions with Platinum(II) Complexes
Authors: Krüger Wieland , Sell Michael , Schmutzler Reinhard 
Published: February 2015

Abstract
Alkyldifluorophosphites, ROPF2 (R = p-substituted benzyl group, neopentyl, 1-adamantyl) have been obtained by a new method, involving reaction of the appropriate alkyl trimethylsilylether, ROSiMe3 with chlorodifluorophosphine, PF2Cl. Reactions of these difluorophosphites with platinum(II) complexes of the type [L2PtCl2] (L = PEt3, PPh3) led to products such as trans-[L2PtCl(POF2)] and {[p-XC6H4CH2PPh3]+}2[Pt(POF2)4]2-, (X = H, Me, Cl, NO2). The ease of carbon-oxygen cleavage in ROPF2 is characteristically related to the nature of the leaving group, R.
Acid and Polarity Effects in Benzene Photoreactions with Alkenes and Alkynes
Authors: Bryce-Smith D. , Gilbert A. , Al-Jalal N. , Deshpande R. R. , Grzonka J. , Hems M. A. , Yianni P. 
Published: February 2015

Abstract
The effects of polar solvents and proton donors on various photoreactions of the benzene ring with electron-acceptor alkenes and alkynes are described and discussed in relation to the various electronic excitation mechanisms involved. Proton donors prove valuable as mechanistic probes for polar intermediates in such processes, and can in some systems both initiate and divert reaction pathways.
2-Alkoxy-3-hydroxy-1,2-oxaphospholane-2-oxides (α-hydroxyphostones)
Authors: Pilgram Kurt H. , Gale Laird H. , Pollard Glenn E. 
Published: February 2015

Abstract
The addition-cyclocondensation reactions of three β-hydroxyketones with four dialkyl phosphites gave 2-alkoxy-3-hydroxy-1,2-oxaphospholane-2-oxides (“α-hydroxyphostones”) (7), in moderate yields. In the solid state and in solution, these compounds exist as dimers with hydrogen bonding between the hydroxyl group and the phosphoryl oxygen atom of an adjacent molecule. The crystal and molecular structure of 3-hydroxy-2-methoxy-3,5,5-trimethyl-1,2-oxaphospholane-2-oxide (7 a) has been determined by single-crystal X-ray crystallography: C7H15O4P, monoclinic space group P2-1/n, cell dimensions a = 8.087(1) Å, b = 13.386(2) Å, c = 9.306(1) Å, V = 1007.4 Å3 , Z = 4, final R = 0.052. The five-membered ring is puckered, with the carbon bearing the OH and CH3 groups lying out of the plane of the remaining four atoms in the ring. The doubly bonded oxygen attached to the phosphorus atom and the hydroxyl oxygen are in a cis-relationship. The O(1)-O(4) intermolecular bond distance of 2.75 Å suggests hydrogen bonding. The O(1)-H(1) intermolecular bond distance of 1.97 Å is consistent with this conclusion.
Anthraquinones and Anthraquinone Glycosides from the Roots of Cassia multijuga
Authors: Tiwari R. D. , Singh J. 
Published: February 2015

Abstract
From the roots of Cassia multijuga 1:3-dihydroxy-2-methyl anthraquinone, 1:3:8-tri-hydroxy-6-methoxy-2-methyl anthraquinone, 1:8-dihydroxy-6-methoxy-2-methyl an-thraquinone-3-O-rutinoside and 1:8-dihydroxy-2-methyl anthraquinone-3-O-rutinoside have been isolated and their structures elucidated.
In the Search for New Anticancer Drugs, IV+ Antitumor Activity of Seleno-TEPA
Authors: Konieczny Maria , Gutierrez Peter L. , Sosnovsky George 
Published: February 2015

Abstract
In order to test the effect of selenium on the anticancer activity of alkylating drugs, Seleno-TEPA (4), the selenium analog of the clinically used Thio-TEPA (1) was tested in vivo against the lymphocytic P 388 and lymphoid L1210 murine leukemias. Compound 4 is more active against P 388 leukemia than against L1210, and appears to be active over a narrower concentration range than Thio-TEPA (1). Compound 4 is less active against P 388 leukemia than 1, as evidenced by the T/C values of 164 for 4 and 239 for 1 at a dose of 4.2 mg/kg. The activity of 4 was also evaluated on the HL60 and K 562 human cell lines. Under the conditions of the cell colony assay technique, Seleno-TEPA (4) is less effective than Thio-TEPA (1).
In the Search for New Anticancer Drugs, V+ Study of the Binding of Spin-Labeled Thio-TEPA to Cells
Authors: Konieczny Maria , Gutierrez Peter L. , Sosnovsky George 
Published: February 2015

Abstract
The spin labeled analog, SL-O-TT (2), of Thio-TEPA (1) inhibits

the incorporation of 3H-thymidine by 50% (IC50) at a dose of 2.6 × 10-4 M in L 1210 and at a dose of 6 × 10-4 M in P 388 murine leukemias. On the basis of cell fractionation studies, compound 2 was found to bind about qeually to the cell nuclei, microsomes, and mitochondria. ESR experiments indicate different of immobilization of the label in various fractions. The efficiency of binding of 2 to cells appears to be at least 6%.
In the Search for New Anticancer Drugs, VI+ Structural Modifications of Cyclophosphamide
Authors: Sosnovsky George , Paul Buddha D. 
Published: February 2015

Abstract
Taking into consideration the known mechanism of the drug action of cyclophosphamide (1), several analogs and related compounds 5, 6, 7, 9, 11, 12 and 27 were synthesized, and tested against lymphocytic leukemia P 388 in mice.

Moderate to high activity was found with 5 (T/C × 100 = 243 at a dose of 300 mg/kg), 7 (T/C × 100 = 155 at a dose of 55 mg/kg). None of these compounds was found to be more active than 1 (T/C × 100 = 339 at a dose of 65 mg/kg). Although the essential position C 4 for the enzymatic activation is completely blocked in 5, the compound possesses a high degree of activity. This result justifies a reevaluation of the proposed mechanism of drug action of 1 and its analogs.
Bequeme Synthese von cis-1,2- Bis(diphenylphosphino)ethanplatin(II)- acetyliden / Convenient Synthesis of cis-1,2-Bis(diphen3dphosphino)- ethane-platinum (II) -acetylides
Authors: Sebald Angelika , Wrackmeyer Bernd 
Published: February 2015

Abstract
The title compounds (1) are obtained in quantitative yield from the reaction between dppePtCl2 (2) and alkynyl stannanes (CH3)3 Sn - C ≡ C-R (3) or (CH3)2Sn(C ≡ C-R)2 (4) in boiling tetrahydrofurane. The complexes 1 have been characterised by multinuclear NMR (13PC, 31P, 195Pt).
Contribution to the Chemistry of Boron, 136 [1]. A Reinvestigation of the Existence of 1,3,2-Dioxaborinium(1 + ) Cations
Authors: Narula Chaitanya K. , Nöth Heinrich 
Published: February 2015

Abstract
It is shown that the previously reported 1,3,2-dioxaborinium salts containing tricoordinated boron are in fact tetracoordinated coordination compounds. The same holds for the corresponding triflates.