bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delirium in Neurocritical Care: Uncovering Undisclosed Psychotropic Substance and Medication Use and Stress Exposure by Hair Analysis
Authors: Bögli Stefan Yu , Capone Crescenzo , Baumgartner Markus R. , Quednow Boris B. , Kraemer Thomas , Keller Emanuela , Binz Tina Maria 
Published: July 2024

Abstract

Objective
In intensive care, delirium is frequent, prolongs the stay, increases health care costs, and worsens patient outcome. Several substances and medications as well as stress can impact the risk of delirium; however, assessment of previous exposure to psychotropic agents and stress by self-reports or third-party information is not always reliable. Hair analysis can be used to objectively assess medication and substance use (including chronic alcohol consumption), and allows for the determination of stress-related long-term changes in steroid hormones and endocannabinoids.

Methods
Consecutive adult patients with acute brain injury admitted to the neurocritical care unit were included. Delirium was diagnosed using the Confusion Assessment Method for the Intensive Care Unit. Liquid chromatography coupled with tandem mass spectrometry was used to investigate psychoactive substances and medications, ethyl glucuronide, steroid hormones, and endocannabinoids in hair samples. Univariable and multivariable analyses were used to reveal any associations with the occurrence of delirium.

Results
Of 50 consecutive patients, 21 (42%) were diagnosed with delirium. Detection of antipsychotics or antidepressants in hair was more frequent in patients with delirium (antidepressants: 43% vs. 14%, p = 0.040; antipsychotics: 29% vs. 0%, p = 0.021). These patients also displayed higher ethyl glucuronide levels (p = 0.049). Anandamide (AEA) concentrations were higher in patients with delirium (p = 0.005), whereas oleoylethanolamide (p = 0.045) and palmitoylethanolamide (PEA) (p = 0.017) concentrations were lower in patients with delirium. Backward stepwise logistic regression analysis revealed antidepressants and AEA/PEA to be independent relevant predictors of delirium.

Conclusions
Hair analysis provides crucial and otherwise unattainable information regarding chronic stress and the use of psychotropic substances and medications. Undisclosed antidepressant/antipsychotic use or intense chronic alcohol consumption is susceptible to treatment (continuation of medication or provision of low-dose benzodiazepines in case of alcohol). Chronic stress can be evaluated using stress markers and endocannabinoids in hair, potentially allowing for personalized delirium risk stratification and preventive measures.
SEOM–GEICO clinical guideline on epithelial ovarian cancer (2023)
Authors: Perez-Fidalgo Jose Alejandro , Gálvez-Montosa Fernando , Guerra Eva María , Madariaga Ainhoa , Manzano Aranzazu , Martin-Lorente Cristina , Rubio-Pérez Maria Jesús , Alarcón Jesus , Barretina-Ginesta María Pilar , Gaba Lydia 
Published: July 2024

AbstractIn recent years, the incorporation of new strategies to the therapeutic armamentarium has completely changed the outcomes of epithelial ovarian cancer (EOC). The identification of new predictive and prognostic biomarkers has also enabled the selection of those patients more likely to respond to targeted agents. Nevertheless, EOC is still a highly lethal disease and resistance to many of these new agents is common. The objective of this guideline is to summarize the most relevant strategies to manage EOC, to help the clinician throughout the challenging diagnostic and therapeutic processes and to provide evidence-based recommendations.
Handekzem
Authors: Kränke Birger 
Published: July 2024

ZusammenfassungDas Handekzem in all seinen klinischen Spielarten gehört zu den entzündlichen Hautkrankheiten und zählt zu den häufigsten beruflich bedingten Erkrankungen. Dadurch betrifft es durch Einschränkung der Handlungsfähigkeit Betroffener viele berufliche wie soziale Bereiche mit teils erheblichen finanziellen Konsequenzen und Kosten. Ein adäquates medizinisches Management ermöglicht therapeutische Erfolge und beugt Langzeitbehandlungen, unerwünschten Therapieeffekten und einer schlechten Patienten-Compliance vor. Neue Erkenntnisse auch der Pathophysiologie ermöglichten in den aktuellen Leitlinien eine klinische Klassifikation des Handekzems in vier ätiologische und vier morphologische Subtypen, die Grundlage einer adäquaten Therapieplanung sein sollten. Das diagnostische Procedere wird als Ablaufplan dargestellt, und die therapeutischen Möglichkeiten inklusive ihrer Limitationen werden erläutert.
Ag and Pb isotope systematics in galena ores from southern Sardinia and southern France flag potential silver sources in antiquity
Authors: Albarede Francis , Boni Maria , Blichert-Toft Janne , Vaxevanopoulos Markos , Westner Katrin , Milot Jean , Pinto Marine , Télouk Philippe 
Published: July 2024

AbstractWhile lead isotopes serve to determine potential ore provenance, silver isotopes help evaluate if a specific ore flagged by Pb isotopes has actually been exploited as a silver source of bullion in antiquity. The combination of Ag and Pb isotopes thus constitutes a powerful tool to address provenance and identify potential ore sources. It has recently been observed that the vast majority of silver isotopic abundances in hundreds of silver coins from different historical periods (pre-Roman and Roman, Middle Ages, early modern times) and different localities (Persia, Greece, Rome, Western Europe, England, Spanish Americas) falls in a remarkably narrow interval (± 0.1 permil, or ± 1 on the epsilon scale used by geochemists to enhance the visibility of small isotopic differences, group 1). Five Greek coins and some pieces from Levantine hacksilber hoards dated to the Late Bronze and Early Iron Ages have isotopic abundances somewhat below the range of group 1 (–0.2 to –0.1 permil, or -2 to -1 on the epsilon scale, group 2).The coverage of Ag isotopes in ores from the western Mediterranean, with the exception of Iberia, is inexistant. Here the above-mentioned approach is illustrated with new Pb and Ag isotopic analyses of samples from southern Sardinia and southern France. The majority of Ag isotope compositions of galena samples from Sardinia belongs to group 2 and none to group 1. While scholarly works imply that Sardinia may have provided silver to the Levant during the Iron Age, the exact location of the Sardinian ores that contributed to classical and archaic Greek coins is still unknown. Galena samples from southern France (the Pyrenees, Montagne Noire, Cévennes) are characterized by Ag isotope compositions from both groups 1 and 2, indicating that silver-bearing ore deposits in Gaul could be considered a potential source for silver bullion, both before and during the Roman era.
Current trends and future perspectives in hadron therapy: radiobiology
Authors: Story Michael D. , Davis Anthony J. , Sishc Brock J. 
Published: July 2024

Abstract
Purpose
The purpose of this article was to highlight current and future trends in radiobiology in an effort to move hadron therapy forward through the application of new knowledge in DNA damage and subsequent response to heavy ion radiotherapy, immune oncology and the interconnection between.

Methods
The subject matter begins with a description of the role of radiation in eliciting either an immunogenic or tolerogenic response to radiation exposure. The role of fragmented DNA in an immunogenic response is described, followed by the definitive role that DNA damage and subsequent repair, or not, of complex DNA damage after hadron exposure plays in the survival response of hadron irradiated cells.

Results
The process by which ionizing radiation elicits an immunogenic rather than tolerogenic response is becoming clearer. The timing of fractionated radiotherapy when combined with an immune checkpoint inhibitor is not clear and may be tumor site specific. Furthermore, whether hadron therapy is more effective at generating a durable immunogenic response is unknown.

Conclusions
Cytosolic DNA plays a significant role in eliciting an innate immune response with the likelihood that hadron therapy would generate complex DNA damage that because it is less likely to be repaired, is more likely to become cytosolic DNA, and more likely to activate an immunogenic response. Lastly, DNA repair pathway choice appears to be a credible bio-indicator for hadron therapy selection as well identify druggable targets to enhance hadron therapy.
From Startup to Scaleup: Public Policies for Emerging Entrepreneurial Ecosystems
Authors: Pardo-del-Val Manuela , Cerver-Romero Elvira , Martinez-Perez Juan Francisco , Mohedano-Suanes Antonia 
Published: July 2024

AbstractThe transition from startup to scaleup is a complex process, intricately tied to the dynamic ecosystem in which a startup originates and flourishes. Recognizing the substantial socioeconomic benefits that high-growth firms bring to their operating environments, policy makers try to strategically craft public policies to bolster their development, constituting a pivotal facet of entrepreneurial ecosystems (EE). This research aims to identify the challenges to growth faced by startups and to pinpoint policy focal areas conductive to addressing these challenges in an emerging EE. Effective public policies must be tailored to the specific context, serving as enablers while entrusting leadership roles to entrepreneurs and other EE stakeholders. To achieve our objective, we selected an emerging EE and approached entrepreneurs and influential agents in the EE through questionnaires and focus groups. The findings conclude with a set of recommended public policy actions designed to fortify essential components within an emerging EE that fosters the growth of its startups. These actions are categorized into three broad topics: enhancing talent availability, promoting networking opportunities, and reinforcing the entrepreneurial culture of the region.
Heritability and correlations for honey yield, handling ease, brood quantity, and traits related to resilience in a French honeybee population
Authors: Kistler Tristan , Kouchner Coline , Brascamp Evert W. , Dumas Charlène , Mondet Fanny , Vignal Alain , Basso Benjamin , Bijma Piter , Phocas Florence 
Published: July 2024

AbstractThere is growing interest in selective breeding of the honeybee, resulting in the emergence of new breeding projects, often with an emphasis on improving resilience traits, in particular toward brood diseases. Lately, feed autonomy is also gaining importance. Here, we use data from a small breeding nucleus in France to estimate genetic parameters for common bee breeding traits and a novel trait reflecting honey reserves in the brood chamber. Open-mated queens were produced each year from inseminated dams between 2019 and 2021, and ~330 colonies were phenotyped each following year at three periods during the entire beekeeping season. Genetic parameters were estimated using ReML with an animal model. Narrow-sense heritability estimates ranged from low (around 0.15) for calmness and total capped brood surface both measured in early summer, to moderate (0.30 to 0.40) for hygienic behavior in spring, honey yield, and phoretic V. destructor load in early summer. Honey reserves in the brood chamber showed an intermediate heritability throughout the season (around 0.25). Gentleness had a null heritability. Most correlations between phenotypes adjusted for environmental fixed effects were close to zero. Among exceptions, there were honey reserves in the brood chamber in early summer with honey yield (around −0.2) and with the total capped brood surface in early summer (around −0.3). These estimates, although uncertain due to the dataset size, suggest that selection for production and resilience will be effective, even though simultaneous selection for honey yield and feed reserves might be difficult due to a possible genetic antagonism between both traits.
Carbon footprint of mixed farming crop-livestock rotational-based grazing beef systems using long term experimental data
Authors: Pereyra-Goday Fabiana , Jebari Asma , Takahashi Taro , Rovira Pablo , Ayala Walter , Lee Michael R. F. , Rivero M. Jordana , McAuliffe Graham A. 
Published: July 2024

AbstractIn the context of ever-growing demand for food and associated concerns regarding the environmental impacts of high-input agricultural systems, there is growing interest in mixed farm enterprises to deliver greater sustainability compared with mono-enterprise production systems. However, assessments of such systems are complex and require high-resolution data to determine the true value and interconnectivity across enterprises. Given the scarcity of information on mixed crop–livestock systems and the difficulties of its analysis, we perform life cycle assessment using temporally high-resolution data (2019–2022) from a long-term experiment in South America to evaluate the ‘cradle-to-farmgate exit’ greenhouse gas emissions intensities of four rotational crop–livestock systems. Systems evaluated were continuous cropping: 2 years of continuous cropping; short rotation: 2-year continuous cropping plus 2-year pasture; long rotation: 2-year continuous cropping followed by 4-year pasture; and forage rotation: continuous pasture. Emissions intensities for beef throughput were reported as kilograms of carbon dioxide equivalents (CO2-eq) per kilogram of liveweight gain (LWG) using the Intergovernmental Panel for Climate Change’s Sixth Assessment Report (AR6 2021) CO2 characterisation factors. Point estimate results were found to be 11.3, 11.8, 11.8 and 16.4 kg CO2-eq/kg/LWG for continuous cropping, short rotation, long rotation and forage rotation, respectively. Emission averages arising from crops, which were separated from animal-based emissions using economic allocation, were 1.23, 0.53 and 0.52 kg CO2-eq/kg for soybean, wheat and oat, respectively. The inclusion of soil organic carbon stock changes had notable effects on reducing each system’s emissions: by 22.4%, 19.2%, 25.3% and 42.1% under continuous cropping, short rotation, long rotation and forage rotation, respectively, when soil organic carbon was included. Given there are few life cycle assessment studies available on such mixed-enterprise ‘semi-circular’ systems, particularly with novel primary data, this study adds critical knowledge to agri-food-related sustainability literature by addressing environmental issues in complex production systems compared to extant and broad coverage of mono-enterprise systems.
Location-Specific Microstructure Characterization Within AM Bench 2022 Nickel Alloy 718 3D Builds
Authors: Levine L. E. , Williams M. E. , Creuziger A. , Stoudt M. R. , Young S. A. , Moon K. W. , Lane B. M. 
Published: July 2024

AbstractThe Additive Manufacturing Benchmark Test Series (AM Bench) is a broad effort to produce rigorous measurement datasets for validating AM computer simulations across the range of processing, structure, and properties, for many additive manufacturing (AM) build methods and material classes. Here, the microstructures of nickel alloy 718 AM Bench 2022 test artifacts produced using laser-based powder bed fusion (PBF-LB), in both as-built and fully heat-treated conditions, are examined. Cross sections are primarily characterized using large area scanning electron microscopy (SEM) electron backscatter diffraction (EBSD) and example analyses of the crystallographic textures are described. These data are part of a large set of in situ and ex situ measurements from both three-dimensional builds and laser tracks on bare plates. All the measurement data are available online with download links at www.nist.gov/ambench.
The myth of a “human right to sport”: how human rights can lead to true inclusion for children with disability
Authors: Pearce Simone , Sanderson Jay 
Published: July 2024

AbstractFundamental Principle 4 of the Olympic Charter provides, ‘[t]he practice of sport is a human right’. However, to think of the practice of sport as a human right is misleading and potentially unhelpful to the true inclusion of children with disability in sport. The various permutations of a human right to sport—a right in sport; a right to participate in sport; a right to the practice of sport; and a right to sport—result in an attitude that children with disability are provided sporting opportunities in a way that are separate, segregated, or unnecessarily different. In this article, we argue that sport should be thought about and analysed through a different human right: the right to non-discrimination. If the right being applied to the experience for a child with a disability in sport, is that of non-discrimination, then the aim is to provide the child with the same experience as a mainstream child. This also means that the focus changes from providing a right to ‘sport’, which results in access to simply the physical activities of sport and shifts to the experience the child has within a sport. Most importantly, the human right to non-discrimination means that a child with disability should have the opportunity to be included in mainstream sport, with adjustments to provide them with a fair and meaningful contest.
A novel bayesian network-based ensemble classifier chains for multi-label classification
Authors: Wang Zhenwu , Zhang Shiqi , Chen Yang , Han Mengjie , Zhou Yang , Wan Benting 
Published: July 2024

AbstractIn this paper, we address the challenges of random label ordering and limited interpretability associated with Ensemble Classifier Chains (ECC) by introducing a novel ECC method, ECC-MOO&BN, which integrates Bayesian Networks (BN) and Multi-Objective Optimization (MOO). This approach is designed to concurrently overcome these ECC limitations. The ECC-MOO&BN method focuses on extracting diverse and interpretable label orderings for the ECC classifier. We initiated this process by employing mutual information to investigate label relationships and establish the initial structures of the BN. Subsequently, an enhanced NSGA-II algorithm was applied to develop a series of Directed Acyclic Graphs (DAGs) that effectively balance the likelihood and complexity of the BN structure. The rationale behind using the MOO method lies in its ability to optimize both complexity and likelihood simultaneously, which not only diversifies DAG generation but also helps avoid overfitting during the production of label orderings. The DAGs, once sorted topologically, yielded a series of label orderings, which were then seamlessly integrated into the ECC framework for addressing multi-label classification (MLC) problems. Experimental results show that when benchmarked against eleven leading-edge MLC algorithms, our proposed method achieves the highest average ranking across seven evaluation criteria on nine out of thirteen MLC datasets. The results of the Friedman test and Nemenyi test also indicate that the performance of the proposed method has a significant advantage compared to other algorithms.
Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications
Authors: Meng Tingting , He Danfeng , Han Zhuolei , Shi Rong , Wang Yuhan , Ren Bibo , Zhang Cheng , Mao Zhengwei , Luo Gaoxing , Deng Jun 
Published: July 2024

AbstractMacrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease symptoms. Nanomaterials (NMs) have been engineered to monitor macrophage metabolism, enabling the evaluation of disease progression and the replication of intricate physiological signal patterns. They achieve this either directly or by delivering regulatory signals, thereby mapping phenotype to effector functions through metabolic repurposing to customize macrophage fate for therapy. However, a comprehensive summary regarding NM-mediated macrophage visualization and coordinated metabolic rewiring to maintain phenotypic equilibrium is currently lacking. This review aims to address this gap by outlining recent advancements in NM-based metabolic immunotherapy. We initially explore the relationship between metabolism, polarization, and disease, before delving into recent NM innovations that visualize macrophage activity to elucidate disease onset and fine-tune its fate through metabolic remodeling for macrophage-centered immunotherapy. Finally, we discuss the prospects and challenges of NM-mediated metabolic immunotherapy, aiming to accelerate clinical translation. We anticipate that this review will serve as a valuable reference for researchers seeking to leverage novel metabolic intervention-matched immunomodulators in macrophages or other fields of immune engineering.
Boosting Electrochemical Urea Synthesis via Constructing Ordered Pd–Zn Active Pair
Authors: Zhou Weiliang , Feng Chao , Li Xuan , Jiang Xingxing , Jing Lingyan , Qi Shuai , Huo Qihua , Lv Miaoyuan , Chen Xinbao , Huang Tianchi , Zhao Jingwen , Meng Na , Yang Hengpan , Hu Qi , He Chuanxin 
Published: July 2024

AbstractElectrochemical co-reduction of nitrate (NO3–) and carbon dioxide (CO2) has been widely regarded as a promising route to produce urea under ambient conditions, however the yield rate of urea has remained limited. Here, we report an atomically ordered intermetallic pallium-zinc (PdZn) electrocatalyst comprising a high density of PdZn pairs for boosting urea electrosynthesis. It is found that Pd and Zn are responsible for the adsorption and activation of NO3– and CO2, respectively, and thus the co-adsorption and co-activation NO3– and CO2 are achieved in ordered PdZn pairs. More importantly, the ordered and well-defined PdZn pairs provide a dual-site geometric structure conducive to the key C–N coupling with a low kinetical barrier, as demonstrated on both operando measurements and theoretical calculations. Consequently, the PdZn electrocatalyst displays excellent performance for the co-reduction to generate urea with a maximum urea Faradaic efficiency of 62.78% and a urea yield rate of 1274.42 μg mg–1 h–1, and the latter is 1.5-fold larger than disordered pairs in PdZn alloys. This work paves new pathways to boost urea electrosynthesis via constructing ordered dual-metal pairs.
Enhancement the physical properties of V2O5/Ni0.1Fe2.9O4 nanocomposite
Authors: Ramadan Rania 
Published: July 2024

AbstractNanocomposite containing vanadium oxide (V2O5) and magnetite (Fe3O4) doped with nickel (Ni) ion were synthesized according to the formula of Ni0.1Fe2.9O4 /V2O5. The obtained composition was characterized by XRD, FTIR, FESEM. The FESEM micrograph shows that the existence of two different phases related to V2O5 and Ni-Magnetite. Moreover,the roughness parameters have values of 281, 85 and 385nm for roughness average Ra, root mean square roughness Rq, Maximum height of roughness RT respectively. Moreover, the magnetic behavior of the sample was studied, and we found that by adding V2O5 to Ni dopped magnetite, the curie temperature value was lowered from 750 oC to 625 oC. The activation energy was calculated and found to be 0.22 eV and 0.08 eV for 1000 Hz and 3MHz respectively.
Information geometry of Wasserstein statistics on shapes and affine deformations
Authors: Amari Shun-ichi , Matsuda Takeru 
Published: July 2024

AbstractInformation geometry and Wasserstein geometry are two main structures introduced in a manifold of probability distributions, and they capture its different characteristics. We study characteristics of Wasserstein geometry in the framework of [32] for the affine deformation statistical model, which is a multi-dimensional generalization of the location-scale model. We compare merits and demerits of estimators based on information geometry and Wasserstein geometry. The shape of a probability distribution and its affine deformation are separated in the Wasserstein geometry, showing its robustness against the waveform perturbation in exchange for the loss in Fisher efficiency. We show that the Wasserstein estimator is the moment estimator in the case of the elliptically symmetric affine deformation model. It coincides with the information-geometrical estimator (maximum-likelihood estimator) when the waveform is Gaussian. The role of the Wasserstein efficiency is elucidated in terms of robustness against waveform change.