bluuebunny/crossref_metadata_2025_split huggingface dataset:
« Gegen-Haltung » : La collection Henkel de livres d’artistes de la RDA, conservée au Getty Research Institute
Authors: Horakova Anna 
Published: June 2024

Avant 1989, la scène artistique et littéraire non officielle qui s’était développée en République démocratique allemande au cours de sa dernière décennie d’existence faisait circuler ses œuvres multimédias principalement par le biais d’un réseau de périodiques et de livres d’artistes produits de façon artisanale. Après la chute du mur de Berlin, ces publications ont été conservées dans des fonds d’archives en Allemagne, au Royaume-Uni et aux États-Unis. Cet article a pour but d’analyser un fonds peu étudié jusqu’à présent, la collection Henkel, conservée au Getty Research Institute de Los Angeles. Celle-ci a été offerte au GRI par le collectionneur et spécialiste allemand du livre d’art Jens Henkel. En prenant la collection Henkel comme cas d’étude, cette contribution examine comment les livres d’artistes produits en RDA peuvent nous conduire à modifier notre compréhension de l’ambition de ces objets, à savoir « faire entendre une voix ou rendre une vision accessible » (Johanna Drucker). En mettant l’accent sur leur intermédialité radicale, leurs formats non conventionnels, leurs contenus singuliers et leurs références aux mouvements historiques et néo-avant-gardistes, cette étude s’applique à démontrer que les livres d’artistes et les périodiques faits à la main et produits, entre autres, par Uwe Warnke, Gabriele Stötzer, Stefan Th. Wagner, Bert Papenfuß, Jörg Kowalski et Ulrich Tarlatt constituent une forme d’opposition ou, pour reprendre les termes de Henkel, une « Gegen-Haltung » face aux mécanismes complexes de la censure en RDA.
Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse
Authors: Xu Lei-Mei , Yu Xin-Xin , Zhang Ning , Chen Yi-Song 
Published: June 2024

BACKGROUND
Pelvic organ prolapse (POP) involves pelvic organ herniation into the vagina due to pelvic floor tissue laxity, and vaginal structure is an essential factor. In POP, the vaginal walls exhibit abnormal collagen distribution and decreased fibroblast levels and functions. The intricate etiology of POP and the prohibition of transvaginal meshes in pelvic reconstruction surgery present challenges in targeted therapy development. Human umbilical cord mesenchymal stromal cells (hucMSCs) present limitations, but their exosomes (hucMSC-Exo) are promising therapeutic tools for promoting fibroblast proliferation and extracellular matrix remodeling.
AIM
To investigate the effects of hucMSC-Exo on the functions of primary vaginal fibroblasts and to elucidate the underlying mechanism involved.
METHODS
Human vaginal wall collagen content was assessed by Masson’s trichrome and Sirius blue staining. Gene expression differences in fibroblasts from patients with and without POP were assessed via RNA sequencing (RNA-seq). The effects of hucMSC-Exo on fibroblasts were determined via functional experiments in vitro . RNA-seq data from fibroblasts exposed to hucMSC-Exo and microRNA (miRNA) sequencing data from hucMSC-Exo were jointly analyzed to identify effective molecules.
RESULTS
In POP, the vaginal wall exhibited abnormal collagen distribution and reduced fibroblast 1 quality and quantity. Treatment with 4 or 6 μg/mL hucMSC-Exo suppressed inflammation in POP group fibroblasts, stimulated primary fibroblast growth, and elevated collagen I (Col1) production in vitro . High-throughput RNA-seq of fibroblasts treated with hucMSC-Exo and miRNA sequencing of hucMSC-Exo revealed that abundant exosomal miRNAs downregulated matrix metalloproteinase 11 (MMP11) expression.
CONCLUSION
HucMSC-Exo normalized the growth and function of primary fibroblasts from patients with POP by promoting cell growth and Col1 expression in vitro . Abundant miRNAs in hucMSC-Exo targeted and downregulated MMP11 expression. HucMSC-Exo-based therapy may be ideal for safely and effectively treating POP.
Epidemiology and Clinical Features of Burkholderia Bacteremia at a Hospital in India
Authors: Kar Mitra , Tejan Nidhi , Jamwal Ashima , Dubey Akanksha , Singh Romya , Sahu Chinmoy , Patel Sangram Singh , Kumari Pooja , Ghar Malay 
Published: June 2024

ABSTRACT.
Burkholderia spp. are opportunistic pathogens that cause infection in patients with disrupted immunity. The study intended to demonstrate the epidemiology and clinical features associated with Burkholderia spp. bacteremia. This retrospective study was performed to assess the clinical and laboratory characteristics of patients whose blood cultures were growing Burkholderia spp. and, based on their underlying comorbidities, were subjected to survival analysis from January 2022 to December 2022 at a university hospital in northern India. Three hundred patients with Burkholderia spp. bacteremia were included in this study conducted over 1 year. The mean age of the patients was 33.86 years with a male predominance of 56.67% (170/300, 56.67%). Underlying malignancies (207/300, 69.0%) were the most common clinical diagnosis, and catheter in situ (300/300, 100.0%) was the most common risk factor. Burkholderia cenocepacia (244/300, 81.33%) was the most common Burkholderia spp. isolated. All isolates were highly susceptible to minocycline. Kidney disease (P = 0.029), hypertension (P = 0.005), type 2 diabetes mellitus (P = 0.039), and respiratory disease (P <0.001) in patients were significantly associated with death owing to Burkholderia spp. bacteremia, whereas patients with malignancies (P <0.001) and undergoing treatment were significantly associated with a better outcome when the microorganism was susceptible to empirical antibiotics. The presence of indwelling devices, mechanical ventilation (P <0.001), and a hemodialysis catheter (P = 0.026) were statistically significant risk factors associated with poor outcomes.
Integrated Serosurveillance for Onchocerciasis, Lymphatic Filariasis, and Schistosomiasis in North Darfur, Sudan
Authors: Coalson Jenna E. , Noland Gregory S. , Nute Andrew W. , Goodhew Erica Brook , Martin Diana L. , Abdalla Zeinab , Zarroug Isam , Gabralla Soheir , Ismail Hassan Ahmed Hassan Ahmed , Secor William Evan , Callahan Elizabeth Kelly , Sanders Angelia M. , Elshafie Balgesa , Nash Scott D. 
Published: June 2024

ABSTRACT.
Sudan is endemic for multiple neglected tropical diseases, including trachoma, onchocerciasis (OV), lymphatic filariasis (LF), and schistosomiasis (SCH). In 2019, dried blood spot samples were collected for a baseline trachoma serosurvey in three localities (El Seraif, Kotom, and Saraf Omrah) in North Darfur State. None were classified previously as OV- or LF-endemic, although low levels of SCH had been identified in all three. Approximately 30 households from 25 communities in each locality were selected by multistage cluster random sampling. Collections of DBSs were analyzed by multiplex bead assay for antibodies to multiple pathogens. This paper presents data on OV (Ov16), LF (Wb123, Bm14, Bm33), and SCH (soluble egg antigen [SEA], Sm25) antibodies among 8,322 individuals from 2,119 households. The survey-adjusted seroprevalence estimates for Ov16 were <0.3% in all localities. Lymphatic filariasis–antigen seroprevalences were discordant. Seroprevalence estimates ranged from 4.6–6.0% (Wb123), 0.99–1.4% (Bm14), and 29.2–33.3% (Bm33). Schistosomiasis seroprevalence estimates among school-aged children ranged from 2.7–8.0% (SEA) and 10.9–15.6% (Sm25). Ov16 seropositivity was low and supported the localities’ classification as nonendemic. The results suggested LF exposure, but discordance between antigens, challenges defining seropositivity thresholds, and the absence of programmatic guidance based on antibody serology alone for Wuchereria bancrofti indicate a need for remapping surveys to confirm transmission. Schistosomiasis antibody levels were high enough to warrant further mapping to guide treatment decisions. The lack of gold standards limited interpretation of results, particularly for LF, but in resource-challenged areas, integrated serological surveillance offers the possibility of efficient monitoring of exposure to multiple diseases.
Severity of Trachomatous Scarring among Adults in Trachoma-Endemic Amhara Region of Ethiopia
Authors: Bromfield Jaymie A. , Aguwa Ugochi T. , Sata Eshetu , Jensen Kimberly A. , Mihretu Fetene , Callahan E. Kelly , West Sheila K. , Wolle Meraf A. , Nash Scott D. 
Published: June 2024

ABSTRACT.
Trachomatous scarring has been shown to progress regardless of active ocular Chlamydia trachomatis infection, indicating that scarring drivers may be unrelated to ongoing transmission. Although scarring prevalence is commonly associated with older age and female sex, less is known about other potential contributors to its development. This study identified and assessed risk factors associated with scarring magnitude in a trachoma-endemic setting, utilizing a five-point photographic scale (S0–S4). During 2017 trachoma surveys of Amhara, Ethiopia, photographers captured left and right conjunctival images of adults (ages 15 years and older) from 10 districts. Subsequently, two graders independently assessed photographs for scarring, with discrepancies adjudicated by an expert grader. Scarring scores for 729 individuals were aggregated from the eye level to the participant level, excluding 17 participants because of poor photograph quality. Among those with scarring, most cases (20.4%) were severe (S4, comprising more than 90% of the tarsal conjunctiva) compared with the prevalence of moderate S3-A/B (11.2%), S2 (8.3%), and mild S1 (19.2%). The youngest group (ages 15–19 years) exhibited all scarring stages. Older participants (60 years and older) experienced a greater burden of severe scarring (S4 prevalence: 32.6%) than their younger (15–19 years) counterparts (6.2%). Multivariate ordinal logistic regression models indicated female sex, increasing age, and district-level trachomatous follicular–inflammation prevalence were significant predictors of scarring severity. Trachomatous scarring and its progression to trichiasis, may prove a barrier to meeting WHO timelines for trachoma elimination and will necessitate ongoing surveillance and interventions after elimination thresholds have been met.
Do Residents Believe that Onchocerciasis Transmission Was Eliminated? Results of A Post-Treatment Surveillance Knowledge, Attitude, and Practices Survey in Three Foci of Uganda
Authors: Bernard Lauri , Khainza Annet T. , Byamukama Edson , Katabarwa Moses , Coalson Jenna , Noland Gregory S. , Richards Frank O. 
Published: June 2024

ABSTRACT.
In Uganda, 15 of 17 foci have interrupted transmission of onchocerciasis (river blindness) and stopped mass drug administration (MDA) of ivermectin. This 2016 study describes the results of a knowledge, attitude, and practices survey regarding river blindness among participants (N = 1,577) 3–5 years after ivermectin MDA was halted in three foci: Imaramagambo halted in 2012, Kashoya-Kitomi in 2013, and Mt. Elgon in 2011. The study showed high levels of composite knowledge (focus-specific range: 66.8–81.2%) related to river blindness transmission, signs, symptoms, and treatment. However, 38.1% of respondents did not know that blackflies transmitted river blindness. Notably, 72.2% claimed they had not been informed why MDA was stopped, 56.3% did not believe river blindness had been eliminated, and 83.1% wanted ivermectin MDA to resume. During the 3–5 year post-treatment surveillance period, only 27.7% (438 of 1,577) reported being informed of what to do once treatments stopped, with the most knowledgeable hailing from the Mt. Elgon focus (47.9%). This study reinforces the need for programs to intensify health education and information dissemination when MDA is stopped. Programs must remind residents that although biting insects may persist, they no longer transmit river blindness. Incorporating messages about the elimination of river blindness into community health education campaigns can help improve the community’s perceptions related to the disease’s absence and the ending of a long-standing MDA intervention.
Digital twins and their economically effective using in the logistics field
Authors: Mayorov A. V. , Egorova N. Yu. 
Published: June 2024

The characteristics of digital twin technology are given and its use in the field of logistics operations is described. The digitalization of business processes and current concepts of Industry 4.0 and Logistics 4.0, the possibility of using simulation models in the context of improving the technological base of information systems are considered.The need for digitalization in modern Industry 4.0 and Logistics 4.0 is indicated, since currently the most effective way to improve production, speed of transportation, and responsiveness of an organization’s business processes is the introduction of digital technologies, one of which is a digital twin. With its help, it becomes possible to create virtual copies of warehouses, conveyors and even cities. The introduction of this technology provides new opportunities for data analysis and risk-free forecasting of scenarios for the behavior of a digital model, and conducting all kinds of stress tests. When integrated with Internet of Things technology, data can be analyzed in real time and compared with other digitized objects. This approach helps improve the efficiency of both the specific problematic element of the supply chain and the entire system as a whole. It is also possible to improve the safety of workers; the model independently learns from its mistakes using machine learning and displays the results of its activities to people.Digital twins not only show a copy of the required element, but also understand its dynamics, predict behavior, and are also capable of analyzing their own activities.
Creation of low-waste technologies at Russian Railways through the introduction of the Bars pyrolysis plant
Authors: Belevtseva A. N. 
Published: June 2024

The volume of industrial and household waste is growing annually, for the storage of which agricultural land is being withdrawn. Waste produced by Russian Railways can cause the destruction of natural ecosystems and lead to the extinction of species.To reduce the impact on natural ecosystems, Russian Railways financed the construction of the largest waste recycling plant in Russia. The uniqueness of the plant lies in its closed-loop processing system without oxygen access. No harmful substances are released into the atmosphere during the combustion process. This method of waste disposal is intended for the processing and disposal of tires, rubber-containing, polymer-containing waste, oil sludge and waste oils.Introduction of modern waste recycling technologies (Bars pyrolysis plant) by all divisions of JSC Russian Railways, it will help reduce the negative impact on the environment, will allow you to quickly and efficiently dispose of hazardous waste, as well as be cost-effective by obtaining secondary raw materials that will give the company profit and pay off the cost of installing equipment.
Kajian Biblika Tentang Allah Tritunggal Untuk Menyikapi Keimanan Terhadap “Tuhan Yang Maha Esa” Dalam Bingkai Iman Kristen
Authors: Pasaribu Ferdinan , Sakkiadat Anetrin 
Published: June 2024

Pemahaman manusia akan Allah tetap saja terbatas karena Allah itu tak terbatas adanya dan kemungkinan besar pemahaman manusia pun bisa berbeda walau sumbernya sama. Hal pertama menyangkut istilah KeAllahan. Istilah “Trinitas” atau “Trinity” tidak ada di dalam Alkitab. Istilah yang ada adalah Keallahan (Divinity atau Godhead). Istilah Trinitas muncul sebagai hasil usaha manusia (gereja) memanahami Allah di dalam Alkitab. Dalam penulisan karya ilmiah ini penulis menggunakan pendekatan kualitatif dengan metode deskriptif dan menggunakan berbagai literatur. Tujuan dari penulisan karya ilmiah ini ialah untuk memberikan pengetahuan mengenai Tuhan yang Esa.
Relato de experiência: a dimensão social da docência
Authors: Lopes Rosimeire Batista 
Published: June 2024

O presente relato propõe uma reflexão acerca do ofício da educação, apresentando os desafios encontrados nas atividades diárias advindas do ato de lecionar, a fim de favorecer a construção da identidade docente. O objetivo é evidenciar as adversidades encontradas no início da carreira, além de revelar as aprendizagens provenientes da experiência profissional. Para seu desenvolvimento foram apresentados os caminhos percorridos durante a trajetória como educadora, explorando a conexão da experiência com a literatura contemplada. Os resultados observados apontam a relevância de aprimorar as competências socioemocionais dos estudantes, além da construção da identidade docente, motivação profissional e necessidade de instigar a aprendizagem ativa. Assim sendo, no contexto do conhecimento dos conteúdos, é fundamental que os discentes se tornem cidadãos reflexivos e engajados na sociedade, visando um mundo com empatia e respeito ao próximo. Nesse viés, é perceptível a dimensão social do trabalho docente, já que, o professor precisa desenvolver o protagonismo estudantil no ambiente educacional, para ser perceptível na sociedade. Entretanto, o professor precisa de valorização e respeito, para que, a motivação seja vivenciada, e, consequentemente, excelência no seu desempenho profissional.
HUBUNGAN KEPUASAN KERJA PERAWAT DENGAN SIKAP ETIS PERAWAT TERHADAP PASIEN
Authors: Damayanti Ranti , Setiadi Diding Kelana , Inriyana Ria 
Published: June 2024

Kepuasan kerja diduga dapat menentukan atau mendorong kinerja perawat ke arah yang baik atau sebaliknya. Salah satu yang termasuk ke dalam kinerja perawat adalah sikap etis perawat terhadap pasien. Penelitian ini bertujuan untuk mengetahui hubungan kepuasan kerja perawat dengan sikap etis perawat terhadap pasien. Penelitian ini adalah penelitian kuantitatif dengan desain cross sectional. Penelitian ini melibatkan seluruh perawat pelaksana di 11 ruang rawat inap Rumah Sakit Umum Daerah Sumedang dengan jumlah sampel 160 responden yang dipilih melalui simple random sampling. Pengambilan data dilakukan dengan menggunakan kuesioner untuk mengukur kepuasan kerja dan sikap etis perawat terhadap pasien dengan bentuk google form. Hasil penelitian menunjukkan 94,37% responden memiliki tingkat kepuasan kerja tinggi. Sebagian besar responden memiliki sikap etis yang baik terhadap pasien (90,00%). Hasil uji spearman correlation diperoleh nilai p= 0,001 dengan koefisien korelasi 0,677, yang berarti ada hubungan kuat dan memiliki arah positif antara kepuasan kerja perawat dengan sikap etis perawat terhadap pasien. Disarankan pihak rumah sakit untuk melakukan pengukuran kepuasan kerja perawat dan evaluasi untuk mempertahankan kepuasan kerja perawat tetap tinggi sehingga menunjukkan sikap yang positif. Job satisfaction is believed to influence or drive nurse performance positively or negatively. One aspect of nurse performance is the ethical attitude of nurses towards patients. This study aims to determine the relationship between nurse job satisfaction and the moral attitude of nurses toward patients. This is a quantitative study with a cross-sectional design. The study involved all implementing nurses in 11 inpatient wards of Sumedang Regional General Hospital, with a sample size of 160 respondents selected through simple random sampling. Data collection was conducted using a questionnaire to measure job satisfaction and the ethical attitude of nurses towards patients via Google Forms. The results showed that 94.37% of respondents had high job satisfaction. Most respondents had a good ethical attitude towards patients (90.00%). The Spearman correlation test results showed a p-value of 0.001 with a correlation coefficient of 0.677, indicating a strong and positive relationship between nurse job satisfaction and the ethical attitude of nurses towards patients. It is recommended that the hospital conduct regular measurements of nurse job satisfaction and evaluations to maintain high job satisfaction, thus fostering a positive attitude.
HUBUNGAN TINGKAT PENGETAHUAN DENGAN PENERAPAN EARLY WARNING SYSTEM (EWS) OLEH PERAWAT DI RUANG RAWAT INAP
Authors: Djala Fany Lairin , Nirmalasari Nining , Yulius  
Published: June 2024

Kematian adalah salah satu indikator mutu pelayanan kesehatan yang sangat penting. Tingginya angka kematian di rumah sakit merupakan pertanda kemungkinan adanya masalah mutu pelayanan yang membutuhkan tindakan perbaikan, salah satunya adalah penerapan Early Warning Sytem (EWS). Keberhasilan penerapan EWS oleh perawat salah satunya dipengaruhi oleh faktor pengetahuan. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan dengan penerapan EWS oleh perawat di ruang rawat inap Rumah Sakit Umum Daerah Poso. Desain penelitian ini menggunakan deskriptif korelasional dengan pendekatan cross-sectional. Populasi penelitian ini yaitu perawat di ruang rawat inap RSUD Poso. Sampel penelitian ini berjumlah 56 perawat. Data dianalisis dengan menggunakan uji statistik menggunakan fisher-exact. Hasil penelitian ini menunjukkan sebagian besar responden memiliki pengetahuan baik (96,4%). Penerapan EWS oleh perawat dalam kategori baik (85,7%). Ada hubungan yang signifikan antara pengetahuan perawat dengan penerapan EWS (p=0,000). Upaya peningkatan pengetahuan tentang penerapan EWS perlu ditingkatkan melalui pelatihan dan penyegaran informasi.

Mortality is one of the most important indicators of the quality of healthcare services. High mortality rates in hospitals may indicate potential quality issues that require corrective actions, such as implementing an Early Warning System (EWS). Their level of knowledge influences the successful implementation of EWS by nurses. This study aims to determine the relationship between the level of knowledge and the implementation of EWS by nurses in the inpatient wards of Poso Regional General Hospital. This research design uses a descriptive correlational approach with a cross-sectional method. The study population consisted of nurses in the inpatient wards of Poso Regional General Hospital, with a sample size of 56 nurses. Data were analyzed using the Fisher exact test. The results showed that the majority of respondents had good knowledge (96.4%), and the implementation of EWS by nurses was in a good category (85.7%). There is a significant relationship between nurses' knowledge and the implementation of EWS (p=0.000). Efforts to improve knowledge about the implementation of EWS need to be enhanced through training and information refreshment.
WEBSITE PENGADUAN MASYARAKAT DESA SUKARAPIH MENGGUNAKAN METODE PROTOTYPE
Authors: Nurul Ilham  , Anik Sri Wahyuningsih  
Published: June 2024

Salah satu Peningkatan kualitas pelayanan public bagi masyarakat pedesaan adalah dapat dengan dilakukan melalui sebuah penyelesaian pengaduan yang mendapatkan respon yang cepat dari penyedia layanan yaitu dalam hal ini instansi pemerintah terkait baik di pusat maupun daerah. Segala bentuk kritik, saran maupun aduan yang disampaikan masyarakat pada suatu instansi merupakan sebuah koreksi untuk perbaikan pelayanan tersebut. Banyak Kantor Desa di Indonesia belum memiliki sistem layanan pengaduan yang teridentifikasi dan terdokumentasi dengan baik, sehingga timbul kendala dalam memberikan layanan pengaduan kepada masyarakat, seperti respon time pelayanan yang lambat dan dokumentasi pengaduan tidak tertata dengan rapi.
Kendala lain timbul saat masyarakat kebingungan untuk menyampaikan keluhan tersebut dikarenakan tidak mengetahui harus mengadu kemana. Untuk mengatasi masalah tersebut, akan dirancang aplikasi layanan pengaduan berbasis Website yang menggunakan model prototype dan menggunakan MySql sebagai database pada server yang digunakan. Dengan itu diharapkan agar dapat memudahkan masyarakat dalam membuat laporan pengaduan. Aplikasi Website ini dapat digunakan masyarakat untuk melakukan layanan pengaduan secara online. Aplikasi ini juga dapat memudahkan Pemerintah desa dalam melakukan dokumentasi dan mengevaluasi sistem layanan pengaduan masyarakat desa.