bluuebunny/crossref_metadata_2025_split huggingface dataset:
Koebner Phenomenon in an ANCA‐Positive Patient with Pyoderma Gangrenosum
Authors: Papi Massimo , Didona Biagio , Chinni Luca Massimo , Gobello Tommaso , Mazzanti Cinzia , De Pità Ornella , Cavalieri Rino 
Published: April 2015

AbstractA male with pyoderma gangrenosum is reported. The clinical and histological features were typical. The initial lesions resolved with characteristic cribriform scars. A few days after the complete recovery, he developed several necrotizing focal lesions localized to the scarred areas. A further histological examination revealed a granulation tissue rich in neutrophils and signs of necrotizing vasculitis. We found a high titer of circulating perinuclear antineutrophil antibodies (p‐ANCA), which are a serological marker for various systemic diseases. An immunological circulating factor has been repeatedly suggested to be the “primum movens” of pyoderma gangrenosum. We discuss the unusual clinical presentation interpreted as a Koebner phenomenon and the possible role of immune factors in enhancing circulating‐endothelial cell interactions in relation to the pathogenesis of pyoderma gangrenosum.
Clear Cell Acanthoma Developing in Epidermal Nevus
Authors: Yamasaki Kenshi , Hatamochi Atsushi , Shinkai Hiroshi , Manabe Toshiaki 
Published: April 2015

AbstractA 33‐year‐old Japanese woman presented with a black papule on a pigmented lesion which had been on her right thigh since her early childhood. A hematoxylin‐eosin‐stained section revealed a sharply demarcated, acanthotic epidermis composed of enlarged clear cells, which stained positively for epithelial membrane antigen and negatively for carcinoembryonic antigen. With antikeratin antibodies, the tumor cells stained for AE1 and AE3, but did not stain for CAM5.2. They contained abundant glycogen. Histologically, we diagnosed the case as a clear cell acanthoma which developed in the pre‐existing epidermal nevus. This is the second such case in the literature.
A Case of Hidroacanthoma Simplex
Authors: Suh Ho Seok , Lee Hwa Jung , Kim Hyun Su , Choi Jee Ho , Sung Kyung Jeh , Moon Kee Chan , Koh Jai Kyoung 
Published: April 2015

AbstractThere are many conditions characterized by nests of cells within the epidermis. One of them, hidroacanthoma simplex, has been regarded as an epidermal tumor differentiating to intraepidermal eccrine duct cell. We report a case of hidroacanthoma simplex with the results of immunohistochemical study. Staining for 35βH11 (reacting with keratin No. 8), 35βE12 (reacting with keratin No. 1, 5, 10, 11), S‐100 protein, and CEA was negative in the tumor cell nests; these monoclonal antibodies stained the nests of eccrine poroma.
Evaluation of Acceleration Plethysmograms in Dermatology—Efficacy of Lipo PGE1 Preparations against Herpes Zoster and Neuralgia Following Herpes
Authors: Okuda Tomoki , Oh‐i Tsunao , Koga Michiyuki 
Published: April 2015

AbstractReports published in recent years indicate that administration of lipo PGE1 is effective against herpes zoster and neuralgia following herpes. However, there are presently no standards to objectively assess efficacy. We therefore looked into the possibility of achieving this goal by using an acceleration plethysmograph. The results showed a significant difference in the rate of change of pulse waves after initiation of drip infusion as compared to before drip infusion among the effective group, the control group, and the non‐effective group. This method appears to be useful to objectively assess both the analgesic effects of lipo PGE1 and the efficacy of drugs in general, based on data analysis. Our results suggest that investigations using this method may be able to predict the therapeutic effects of vasodilators and analyze hemodynamic disorders of the skin.
Dermatomyofibroma (Plaqueförmige Dermale Fibromatose)
Authors: Tani Masashiro , Komura Akihiko , Ichihashi Masamitsu 
Published: April 2015

AbstractWe reported a patient with dermatomyofibroma and reviewed the literature to characterize the immunohistochemical features of dermatomyofibroma.A 25‐year‐old woman presented with an asymptomatic, well‐circumscribed, red‐brown plaque on the left posterior shoulder. Microscopic examination revealed a non‐encapsulated but well‐circumscribed tumor in the mid‐dermis extending into the upper subcutaneous fatty tissue. The tumor was composed of faintly eosinophilic, thin, wavy collagen fibers arranged as intersecting fascicles with an arrangement predominantly parallel to the skin surface. Embedded among the wavy fibers, there were a fair number of nuclei that were elongated, vesicular, and uniform in size. Immunohistochemical studies using a peroxidase‐antiperoxidase technique disclosed that the cytoplasm of the tumor cells was positive for muscle actin. The tumor cells were negative for α‐smooth muscle actin, desmin, factor XIIIa, S‐100 protein, and CD34. Clinical, histopathologic, and immunohistochemical analysis confirmed dermatomyofibroma.
Potential Efficacy of Low Metal Diets and Dental Metal Elimination in the Management of Atopic Dermatitis: An Open Clinical Study
Authors: Adachi Atsuko , Horikawa Tatsuya , Takashima Tsutomu , Komura Tokiko , Komura Akihiko , Tani Masahiro , Ichihashi Masamitsu 
Published: April 2015

AbstractWe performed an open clinical study on the effects of low metal diets and/or dental metal elimination on 27 patients with moderate to severe atopic dermatitis (AD), who showed positive patch tests for metal allergens and/or clinical exacerbation by oral provocation tests with metal salts. All the patients were recommended to ingest low metal diets for 3 months and/or undergo dental metal elimination. Marked or moderate improvement was noted in 18 patients (67%); 7 patients (26%) showed marked improvement and 11 patients (41%), moderate improvement. Nine patients (33%) showed minimal improvement or no change. In the patients who showed marked or moderate improvement, we observed statistically significant decreases (p<0.05) in both peripheral blood eosinophil counts and serum LDH levels after 3 months of treatment. The present study suggests that restriction of ingested metal allergens to which patients have positive patch tests and/or oral challenge tests may be useful in the management of some patients with AD who have metal sensitivity.
Lichen Planus and Sjögren‐type Sicca Syndrome in a Patient with Chronic Hepatitis C
Authors: Tanei Ryoji , Ohta Yukinori , Katsuoka Kensei 
Published: April 2015

AbstractWe report a 54‐year‐old Japanese male with lichen planus and Sjögren‐type sicca syndrome, accompanied by the latent complication of chronic hepatitis C. The patient first showed erythematous and erosive lesions with white irregular striae in the buccal mucous membrane, and blepharitis and hyperemia of conjunctiva in his eyes. He later had two small erosions on the glans penis, and flat‐topped violaceous papules on the dorsa manus and nape. A biopsy specimen of the lower lip lesion demonstrated a lichenoid tissue reaction at the basement membrane zone, and lymphocytic focal accumulations in the salivary glands. Immunohistochemical study of this specimen revealed CD45RO+ (T) cells associated with the expression of HLA‐DR antigens predominantly in both the lichenoid tissue reaction and the lymphocytic sialadenitis. Objective keratoconjunctivitis sicca was confirmed by the Schirmer and Rose‐Bengal tests. Anti‐DNA antibody was positive; however anti‐SS‐A, and anti‐SS‐B antibodies were negative. Increased levels of transaminase enzymes, TTT, ZTT, and IgG were observed in first laboratory examinations; thereafter, anti‐hepatitis C virus (HCV) antibodies and HCV‐RNA were detected. The high serum amylase level, in which salivary amylase predominated, was normalized by etretinate therapy in parallel with the clinical improvement of the oral LP lesions. Our case is considered to support the hypothesis that an etiologic association may be present among lichen planus, Sjögren's syndrome, and chronic hepatitis C.
Evaluation of Soluble Cell Adhesion Molecules in Atopic Dermatitis
Authors: Koide Masayo , Furukawa Fukumi , Tokura Yoshiki , Shirahama Shigeho , Takigawa Masahiro 
Published: April 2015

AbstractRecent studies have indicated the importance of cell adhesion molecules (CAMs) between the vascular endothelium and activated leukocytes in various inflammatory skin diseases. Soluble forms of CAMs (sCAMs) have also been detected in sera from such diseases. In order to elucidate the role of the soluble forms in skin inflammation, we determined the serum levels of E‐selectin, vascular cell adhesion molecule‐1 (VCAM‐1), and intercellular adhesion molecule‐1 (ICAM‐1) in patients with atopic dermatitis (AD). Using an enzyme‐linked immunosorbent assay, we quantified sCAMs levels in 21 patients with atopic dermatitis and in 16 healthy controls. In severe AD patients, levels of these three types of sCAMs were markedly elevated. sE‐selectin was significantly elevated in severe AD over the levels in mild AD. A positive correlation with individual clinical activity was found for changes in the sE‐selectin and sVCAM‐1 levels. sE‐selectin levels were correlated with the serum IgE levels and the number of eosinophils. The sVCAM‐1 level was also significantly correlated with the number of monocytes. Among these three molecules, sE‐selectin appeared to be the most sensitive clinical parameter in monitoring the clinical course of AD patients.
Lymphoepithelioma‐like Carcinoma of the Skin
Authors: Ko Toshiko , Muramatsu Tsutomu , Shirai Toshihiko 
Published: April 2015

AbstractWe report a case of lymphoepithelioma‐like carcinoma of the skin on the right cheek of a 67‐year‐old man. Histologically, the entire dermis was occupied by multiple lobules of atypical epithelial tumor cell nests surrounded by inflammatory cells. Immunohistochemical examination showed that the epithelial tumor cells were positive for cytokeratin and epithelial membrane antigen. The inflammatory cells were positive for leukocyte common antigen and T‐cell marker. Among the tumor nests, small ductal structures were positive for carcinoembryonic antigen. Ultrastructurally, these epithelial tumor cells had well‐developed desmosomes and were joined to each other; no tonofilaments were observed in the cytoplasm. These findings strongly suggest that these tumor cells tended to differentiate to the adnexa of the skin.
Ultrastructure of the Lesions of Psoriasis Vulgaris Transplanted into the Subcutaneous Tissue of Nude Mice by the Skin Fenestrating Transplantation Method
Authors: Ueda Keiichi , Yanagihara Makoto , Fujita Tomozo 
Published: April 2015

AbstractWe have developed a new skin transplantation method, called the skin fenestrating transplantation method, in which the nude mouse skin covering the lesion was removed one week after the transplant was embedded. One week later, transplanted psoriatic skin was biopsied and specimens were examined by electron microscopy. The basal cells and the nuclei of transplanted psoriatic epidermis were long and slender. Projections of basal cells extended to the dermis. Erythrocytes and lymphcytes were seen in the intercellular space. In the spinous cell layer, the cytoplasm and the nuclei were round. In the cytoplasm, mitochondria and endoplasmic reticuli were abundant, and tonofibrillar formation was poor. In the upper part of the epidermis, the cells were horizontally elliptic and, in the cytoplasm, short tonofibril bundles were formed. In the uppermost layers, in the cytoplasm of flat cells, degenerated flat nuclei, low dense lipid droplets and clumps of ribosomes were observed. These findings resembled the findings of intact psoriasis lesions more closely than those obtained by the skin embedding transplantation method.
A Case of Adult T‐cell Leukemia/Lymphoma (ATLL) with Angiocentric and Angiodestructive Features
Authors: Ohtake Naoki , Setoyama Mitsuru , Fukumaru Seita , Kanzaki Tamotsu 
Published: April 2015

AbstractThis report describes a case of adult T‐cell leukemia/lymphoma (ATLL) with angiocentric and angiodestructive features. The patient was a 66‐year‐old Japanese woman who began developing widespread skin lesions ten months prior to admission. The diagnosis of ATLL was made on the basis of her having an antibody to human T‐cell lymphotropic virus type ‐1 (HTLV‐1) and typical flower cells (ATLL cells) in peripheral blood smears. Once hospitalized, the course of her disease was very acute and severe, as is seen with angiocentric lymphoma. Based on histological features, this case was judged not to be angiocentric lymphoma; however, it may lie within the spectrum of angiocentric immunoproliferative lesions (AIL). The findings in this case strongly suggest that HTLV‐1 can be a pathogenic factor in the expression of angiocentric and angiodestructive features in ATLL, as is Epstein‐Barr virus (EBV) (1–4). To our knowledge, the present case is the sixth reported in the literature of lymphoma in which these features are associated with HTLV‐1 infection (5–7).
Bullous Pemphigoid in an HB Virus Carrier: Interaction between Corticosteroids and HB Virus
Authors: Inadomi Toru , Saito Tamiko , Kaneko Miki , Hashimoto Takashi , Suzuki Hiroyuki 
Published: April 2015

AbstractA case of bullous pemphigoid (BP) in a 47‐year‐old female hepatitis B virus (HBV) carrier is reported. Disseminated bullae covered the patient's entire body including the hands and feet. BP was diagnosed on the basis of pathological and immunological observations examining immunofluorescence and cross reactions to both bullous pemphigoid antigen (BPAG) 1 and BPAG 2. Although oral prednisolone (80 mg daily) rapidly healed the eruption, liver function failed to respond, resulting in the patient's death. This liver dysfunction was attributed to the HBV infection. Use of the polymerase chain reaction showed that HBV in this case had transformed into its precore mutation form during the therapy. Standard tests on first examination did not detect HBV in this patient, but later detailed analysis suggested that she had been an HBV carrier since birth. Such carriers sometimes test negative for HBs antigen, when only a little HBV is present in the liver. Great care should also be exercised when using high doses of corticosteroids to treat bullous diseases in HBV carriers, because these drugs may aggravate HBV infections and cause liver failure.
Fixed Drug Eruption Caused by Iopamidol, A Contrast Medium
Authors: Yamauchi Ritsuko , Morita Akimichi , Tsuji Takuo 
Published: April 2015

AbstractWe report a patient who developed a fixed drug eruption caused by the contrast medium, Iopamidol. We diagnosed it by her episode pattern and the results of patch tests. This substance has not been previously implicated as a cause of fixed drug eruption. Immunohistochemical studies showed Fas expression in keratinocytes of the lesion, but not in the uninvolved skin. This finding may explain the preferential localization of fixed drug eruption.
Foot Ulcer Due to Arteriovenous Malformation: Report of a Case
Authors: Lee Sang Goang , Ohtoshi Eriko , Matsuyoshi Norihisa , Ohta Keiji , Horiguchi Yuji , Imamura Sadao 
Published: April 2015

AbstractA 41‐year‐old woman had erosive eruptions surrounded by irregularly shaped pigmentation on the lateral aspect of her right foot, where she had noted gradually increasing warmth and pain for 10 years. The eruptions waxed and waned without complete healing, and an ulcer which had formed one year previously did not respond to topical treatments. Arteriography performed on the right lower extremity disclosed multiple diffuse arteriovenous malformations in the right lower leg and foot. The ulcer was treated by bed rest, surgical debridement, and topical application of bucladesine sodium ointment. After three months, the ulcer healed, leaving a shallow scar and pigmentation.
A Case of Apple‐Shaped Pedunculated Lipofibroma
Authors: Kwon Kyung‐Sool , Seo Kyung‐Hyung , Jang Ho‐Sun , Chung Tae‐Ahn 
Published: April 2015

AbstractIn 1975, Mehregan et al (1) proposed the term pedunculated lipofibroma for the solitary form of NLCS in the view of its distinctive clinicopathologic features. Subsequently, Nogita et al reported and reviewed 32 cases of pedunculated lipofibroma in 1994. Pedunculated lipofibroma is a relatively rare form of benign connective tissue proliferation abnormality characterized by ectopic adipose tissue in the dermis. We observed a case of pedunculated lipofibroma with a prominent stalk containing feeding vessels, a history of congenital onset, a remarkable globular apple‐shaped mass and an accompanying small sessile lesion. We report this case with a review of the literature.
A Case of Linear IgA Disease: An Immunofluorescent Study Using Confocal Laser Scan Microscopy
Authors: Kobayashi Takashi , Konohana Akira , Hattori Shunji 
Published: April 2015

AbstractA 79‐year‐old Japanese woman presented with erythema and bullae on her trunk and limbs. Histological examination of the skin lesions showed subepidermal bullae and polymorphonuclear leukocyte infiltration into the papillary dermis. A direct immunofluorescent study showed the linear deposition of IgA, but not of IgG or IgM, in the basement membrane zone. Indirect immunofluorescence of the serum using confocal laser scan microscopy showed IgA, but not IgG, reactivity in the basement membrane zone. In double immunostaining experiments, IgA reactivity was also observed on the epidermal side; laminin 5 was detected on the dermal side.
Two Cases of Basal Cell Carcinoma Arising in Seborrheic Keratosis
Authors: Akasaka Toshihide , Kon Saiichi 
Published: April 2015

AbstractThe present study reports two cases of basal cell carcinoma arising in seborrheic keratosis. The first case is a seventy‐three‐year‐old female who presented with a blackish nodule arising from a pigmented lesion on her chest. Histopathological analysis of the nodule and the pigmented lesion revealed a basal cell carcinoma with hair follicular differentiation and an acanthotic seborrheic keratosis, respectively. The second case is a seventy‐year‐old female with a blackish nodule arising from a pigmented lesion on her back. Histological analysis of the nodule revealed an atypical basaloid cell mass surrounded by a seborrheic keratosis lesion. In addition to the coexisting seborrheic keratosis with the basal cell carcinoma, a basaloid follicular hamartoma that showed muliple hamartomatous hair follicles or small cysts replaced by a branching cord or lace‐like network of basaloid cells surrounded by fibrovascular stroma was identified. We concluded that both cases presented a rare combination of a seborrheic keratosis which underwent a malignant change to basal cell carcinoma. It appears that both basal cell carcinomas and seborrheic keratosis may derive from a similar source: pluripotential cells of either the epidermis or hair follicle epithelium.
In vitro Comparison between Mouse B16 and Human Melanoma Cell Lines of the Expression of ICAM‐1 Induced by Cytokines and/or Hyperthermia
Authors: Nakayama Juichiro , Guan Xiao‐Chun , Nakashima Manabu , Mashino Toshihiko , Hori Yoshiaki 
Published: April 2015

AbstractThe expression of intercellular adhesion molecule‐1 (ICAM‐1) in mouse B16 and human melanoma cell lines was investigated by indirect immunofluorescence using a FACScan analyzer. Mouse B16 melanoma cell lines (B16‐F1 and F10) did not express ICAM‐1 under ordinary culture conditions. Neither in vitro hyperthermia at 41°C for 3 or 6 hr nor cytokines such as γ interferon (IFN‐γ) or tumor necrosis factor α (TNF‐α) induced ICAM‐1 expression in B16 melanoma cell lines. A combination of IFN‐γ with TNF‐α caused slight induction of ICAM‐1 expression in the B16‐F10 melanoma cell line. Hyperthermia at 41°C for 3 hr in combination with the cytokines induced a slight expression of ICAM‐1 in the B16‐F1 melanoma cell line. Hyperthermia at 41°C for 3 hr or 6 hr did not induce de novo ICAM‐1 expression but hyperthermia at 43°C for 6 hr caused rather suppression of the expression of ICAM‐1 in the three human melanoma cell lines tested. In contrast, they showed a clear increase in the expression of ICAM‐1 after treatment with either with IFN‐γ or TNF‐α, and the expression was further augmented by a combination of the two cytokines. Treatment with cytokines in combination with hyperthermia at 41°C or 43°C for 3 hr did not augment the expression of ICAM‐1 over that in cytokine‐treated human melanoma cell lines, at normal temperatures. Thus, it is concluded that mouse B16‐F1 and F10 melanoma cell lines are different from human melanoma cell lines in terms of induction of ICAM‐1 expression by cytokines and/or hyperthermia.
Phenotypic Differences between Human Blood Monocyte Subpopulations in Psoriasis and Atopic Dermatitis
Authors: Zheng Min , Mrowietz Ulrich 
Published: April 2015

AbstractPeripheral blood monocytes seem to be of importance in the initiation and maintenance of cutaneous inflammatory disorders such as psoriasis and atopic dermatitis. Functional abnormalities of monocytes have been observed in both diseases. We sought to determine whether these abnormalities are reflected by an altered phenotypic expression of functionally active surface molecules. Peripheral blood monocyte subsets varying in cellular density and cell size from patients with psoriasis and atopic dermatitis were investigated using FACS analysis employing a panel of monoclonal antibodies (CD14, CD16, HLA‐DR, HLA‐DQ, FcɛRII, IL‐2R, ICAM‐1, CR3). Furthermore, the modulation of expression by interferon‐γ in monocyte subsets from patients was compared to normal controls. The results show that HLA‐DR and ‐DQ expression on monocyte subsets in psoriatic patients was significantly decreased; “large” monocytes expressed significantly less HLA‐DR than “small” monocyte subpopulations. Decreased HLA‐DR and ‐DQ expression could be upregulated by incubation of psoriatic monocytes with IFNγ. In atopic dermatitis, a different phenotype pattern of monocyte subsets was demonstrated: HLA‐DR expression and HLA‐DQ expression were both decreased in both “large” and “small” monocytes as compared to normal controls. However, there were no significant differences in HLA‐DR and HLA‐DQ expression between “large” and “small” monocyte subpopulations in atopic dermatitis. Moreover, the ICAM‐1 and IL‐2R expression of “large” and “small” monocyte subpopulations was significantly decreased in atopic patients from levels in normal controls and psoriatic patients. The altered expression of HLA‐DR, ‐DQ, ICAM‐1 and IL‐2R could be upregulated by incubation of atopic monocytes with IFNγ. In addition, there was a significant increase in the percentage of monocytes in the differential count of patients with psoriasis or atopic dermatitis. We conclude that the differential phenotype pattern of surface molecules on monocytes in psoriasis and atopic dermatitis may reflect an abnormal monocyte maturation/differentiation state. This may explain the functional abnormalities of monocytes observed in patients with psoriasis and atopic dermatitis.