bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized configuration rules extraction in product service systems by using Local Cluster Neural Network
Authors: Shen Jin , Wu Bin , Yu Li 
Published: September 2015

Purpose
– Configuration systems are used as a means for efficient design of customer tailored product service systems (PSS). In PSS configuration, mapping customer needs with optimal configuration of PSS components have become much more challenging, because more knowledge with personalization aspects has to be considered. However, the extant techniques are hard to be applied to acquire personalized configuration rules. The purpose of this paper is to extract the configuration rule knowledge in symbolism formulation from historical data.

Design/methodology/approach
– Customer characteristics (CCs) are defined and introduced into the construction of configuration rules. Personalized PSS configuration rules (PCRs) are thereby proposed to collect and represent more knowledge. An approach combining Local Cluster Neural Network and Rulex algorithm is proposed to extract rule knowledge from historical data.

Findings
– The personalized configuration rules with CCs are able to alleviate the burden of customers in expressing functional requirements. Furthermore, in the long-term relationship with a customer in PSS realization, PSS offerings can be reconfigured according to the changing CCs with the guide of PCRs.

Originality/value
– The contribution of this paper lies in introducing the attribute of CCs into the antecedents of PCRs and proposing the neural networks-based approach to extracting the rule knowledge from historical data.
What makes MNCs succeed in developing countries?
Authors: Hansen Michael W. , Gwozdz Wencke 
Published: September 2015

Purpose– The purpose of this paper is to examine the evolution in subsidiary performance and the factors influencing this performance based on a unique database of approximately 800 multi-national company (MNC) subsidiaries in developing countries. Developed-country multi-national companies (MNCs) are increasingly establishing subsidiaries in developing countries. The potential gains are high; however, so are the risks. While the issue of subsidiary performance should be at the heart of any international business (IB) enquiry into MNC activity in developing countries, surprisingly little research has examined this issue.Design/methodology/approach– Based on a comprehensive literature review of the IB performance literature, it is hypothesized that subsidiary performance essentially is shaped by five clusters of factors: location, industry, MNC capabilities, subsidiary role and entry strategy. These factors’ ability to explain variance in subsidiary performance is tested through a multiple regression analysis.Findings– MNC subsidiary performance in developing countries has improved enormously in recent decades. Especially, MNC capability and subsidiary role-related factors appear to explain variance in performance, while location factors appear to have less explanatory power. This suggests that strong MNC capabilities and organization can make MNCs succeed regardless of location.Practical implications– The key preparatory work for MNCs contemplating entry into developing countries is to carefully scrutinize internal capabilities and organization.Originality/value– The paper presents a model for explaining variation in subsidiary performance in developing countries specifically. The paper offers unique empirical insights into the state and drivers of subsidiary performance in developing countries.
Sensory approaches in mental health: A scoping review
Authors: Scanlan Justin Newton , Novak Theresa 
Published: September 2015

Background/aimSensory approaches in mental health are designed to assist consumers to regulate physiological and emotional arousal. They have been highlighted as non‐invasive, self‐directed and empowering interventions that may support recovery‐oriented and trauma‐informed mental health practice and may assist in efforts to reduce the use of seclusion and restraint. Over recent years, there has been a substantial increase in research in this area. However, there has not yet been any attempt to map and summarise this literature.MethodA five‐stage scoping review was conducted. Four databases were searched for literature evaluating sensory interventions implemented in mental health settings.ResultsA total of 17 studies were included in the final review. A range of sensory approaches was evaluated and a range of outcomes measured. In general, consumers reported reductions in distress associated with engaging in sensory interventions. Results in terms of reduction of seclusion and restraint were mixed, with some studies reporting a decrease, others reporting no change and one reporting an increase. Methodological limitations in the studies reviewed mean that results should be interpreted with caution.ConclusionsAlthough there is emerging evidence for the usefulness of sensory approaches in supporting consumers’ self‐management of distress, there is less evidence for sensory approaches supporting reductions in seclusion and restraint when used in isolation. More research is necessary, but sensory approaches do appear safe and effective. Services wishing to reduce seclusion and restraint should implement sensory approaches in conjunction with other strategies to achieve this important outcome.
Splenic gene expression profiling in White Leghorn layer inoculated with the Salmonella enterica serovar Enteritidis
Authors: Wu Guixian , Liu Liying , Qi Yukai , Sun Yu , Yang Ning , Xu Guiyun , Zhou Huaijun , Li Xianyao 
Published: September 2015

SummarySalmonella enterica serovar Enteritidis (SE) is a foodborne pathogen that can threaten human health through contaminated poultry products. Live poultry, chicken eggs and meat are primary sources of human salmonellosis. To understand the genetic resistance of egg‐type chickens in response to SE inoculation, global gene expression in the spleen of 20‐week‐old White Leghorn was measured using the Agilent 4 × 44 K chicken microarray at 7 and 14 days following SE inoculation (dpi). Results showed that there were 1363 genes significantly differentially expressed between inoculated and non‐inoculated groups at 7 dpi (I7/N7), of which 682 were up‐regulated and 681 were down‐regulated genes. By contrast, 688 differentially expressed genes were observed at 14 dpi (I14/N14), of which 371 were up‐regulated genes and 317 were down‐regulated genes. There were 33 and 28 immune‐related genes significantly differentially expressed in the comparisons of I7/N7 and I14/N14 respectively. Functional annotation revealed that several Gene Ontology (GO) terms related to immunity were significantly enriched between the inoculated and non‐inoculated groups at 14 dpi but not at 7 dpi, despite a similar number of immune‐related genes identified between I7/N7 and I14/N14. The immune response to SE inoculation changes with different time points following SE inoculation. The complicated interaction between the immune system and metabolism contributes to the immune responses to SE inoculation of egg‐type chickens at 14 dpi at the onset of lay. GC, TNFSF8, CD86, CD274, BLB1 and BLB2 play important roles in response to SE inoculation. The results from this study will deepen the current understanding of the genetic response of the egg‐type chicken to SE inoculation at the onset of egg laying.
Mevastatin ameliorates sphingosine 1‐phosphate‐induced COX‐2/PGE2‐dependent cell migration via FoxO1 and CREB phosphorylation and translocation
Authors: Hsu Chih‐Kai , Lin Chih‐Chung , Hsiao Li‐Der , Yang Chuen‐Mao 
Published: September 2015

Background and PurposeSphingosine 1‐phosphate (S1P), an important inflammatory mediator, has been shown to regulate COX‐2 production and promote various cellular responses such as cell migration. Mevastatin, an inhibitor of 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMG‐CoA), effectively inhibits inflammatory responses. However, the mechanisms underlying S1P‐evoked COX‐2‐dependent cell migration, which is modulated by mevastatin in human tracheal smooth muscle cells (HTSMCs) remain unclear.Experimental ApproachThe expression of COX‐2 was determined by Western blotting, real time‐PCR and promoter analyses. The signalling molecules were investigated by pretreatment with respective pharmacological inhibitors or transfection with siRNAs. The interaction between COX‐2 promoter and transcription factors was determined by chromatin immunoprecipitation assay. Finally, the effect of mevastatin on HTSMC migration and leukocyte counts in BAL fluid and COX‐2 expression induced by S1P was determined by a cell migration assay, cell counting and Western blot.Key ResultsS1P stimulated mTOR activation through the Nox2/ROS and PI3K/Akt pathways, which can further stimulate FoxO1 phosphorylation and translocation to the cytosol. We also found that S1P induced CREB activation and translocation via an mTOR‐independent signalling pathway. Finally, we showed that pretreatment with mevastatin markedly reduced S1P‐induced cell migration and COX‐2/PGE2 production via a PPARγ‐dependent signalling pathway.Conclusions and ImplicationsMevastatin attenuates the S1P‐induced increased expression of COX‐2 and cell migration via the regulation of FoxO1 and CREB phosphorylation and translocation by PPARγ in HTSMCs. Mevastatin could be beneficial for prevention of airway inflammation in the future.
Alcohol use in the Pacific region: Results from the STEPwise approach to surveillance, Global School‐Based Student Health Survey and Youth Risk Behavior Surveillance System
Authors: Kessaram Tara , McKenzie Jeanie , Girin Natalie , Roth Adam , Vivili Paula , Williams Gail , Hoy Damian 
Published: September 2015

AbstractIntroduction and AimsAlcohol use is a leading risk factor for disease and injury in Pacific Island countries and territories (PICT). This paper examines drinking patterns across 20 PICTs.Design and MethodsWe synthesised published data from the STEPwise approach to surveillance or similar surveys for adults 25–64 years, and from the Global School‐Based Student Health surveys and Youth Risk Behavior Surveillance System (YRBSS) for youth. We examined current and heavy drinking, and for adults also frequency of consumption. Using YRBSS, we studied trends in youth alcohol use in US‐affiliated PICTs between 2001 and 2013.ResultsAlcohol consumption in adults and youth varied considerably across PICTs. In eight PICT populations, over 60% of male adults were current drinkers. Male adults consumed alcohol more frequently and engaged in heavy drinking more than female adults. Similar gender differences occurred in current and heavy drinking among youth. Across 10 PICTs, current drinking prevalence in males 13–15 years ranged from 10% to over 40%. Declines in alcohol use among grade 9–12 students were observed in YRBSS, although the magnitude differed by island and sex.Discussion and ConclusionsAlcohol consumption varies widely between PICTs. There are marked gender differences in use and abstention. There is scope in PICTs for implementation of best practice strategies to reduce alcohol‐related harm. These need to be gender responsive and cognisant of concerning patterns of youth drinking. Strengthening surveillance of alcohol use and its consequences is vital to inform and monitor the impact of national and regional policies. [Kessaram T, McKenzie J, Girin N, Roth A, Vivili P, Williams G, Hoy D. Alcohol use in the Pacific region: Results from the STEPwise approach to surveillance, Global School‐Based Student Health Survey and Youth Risk Behavior Surveillance System. Drug Alcohol Rev 2016;35:412–423]
Bioethanol potential from miscanthus with low ILUC risk in the province of Lublin, Poland
Authors: Gerssen‐Gondelach Sarah J. , Wicke Birka , Borzęcka‐Walker Magdalena , Pudełko Rafał , Faaij Andre P. C. 
Published: September 2015

AbstractIncreasing production of biofuels has led to concerns about indirect land‐use change (ILUC). So far, significant efforts have been made to assess potential ILUC effects. But limited attention has been paid to strategies for reducing the extent of ILUC and controlling the type of LUC. This case study assesses five key ILUC mitigation measures to quantify the low‐ILUC‐risk production potential of miscanthus‐based bioethanol in Lublin province (Poland) in 2020. In 2020, a total area of 196 to 818 thousand hectare of agricultural land could be made available for biomass production by realizing above‐baseline yield developments (95–413 thousand ha), increased food chain efficiencies (9–30 thousand ha) and biofuel feedstock production on underutilized lands (92–375 thousand ha). However, a maximum 203–269 thousand hectare is considered legally available (not protected) and biophysically suitable for miscanthus production. The resulting low‐ILUC‐risk bioethanol production potential ranges from 12 to 35 PJ per year. The potential from this region alone is higher than the national Polish target for second‐generation bioethanol consumption of 9 PJ in 2020. Although the sustainable implementation potential may be lower, the province of Lublin could play a key role in achieving this target. This study shows that the mitigation or prevention of ILUC from bioenergy is only possible when an integrated perspective is adopted on the agricultural and bioenergy sectors. Governance and policies on planning and implementing ILUC mitigation are considered vital for realizing a significant bioenergy potential with low ILUC risk. One important aspect in this regard is monitoring the risk of ILUC and the implementation of ILUC mitigation measures. Key parameters for monitoring are land use, land cover and crop yields.
Does phylogeographical structure relate to climatic niche divergence? A test using maritime pine (Pinus pinaster Ait.)
Authors: Serra‐Varela M. J. , Grivet D. , Vincenot L. , Broennimann O. , Gonzalo‐Jiménez J. , Zimmermann N. E. 
Published: September 2015

AbstractAimTo disentangle the effects of environmental and geographical processes driving phylogenetic distances among clades of maritime pine (Pinus pinaster). To assess the implications for conservation management of combining molecular information with species distribution models (SDMs; which predict species distribution based on known occurrence records and on environmental variables).LocationWestern Mediterranean Basin and European Atlantic coast.MethodsWe undertook two cluster analyses for eight genetically defined pine clades based on climatic niche and genetic similarities. We assessed niche similarity by means of a principal component analysis and Schoener's D metric. To calculate genetic similarity, we used the unweighted pair group method with arithmetic mean based on Nei's distance using 266 single nucleotide polymorphisms. We then assessed the contribution of environmental and geographical distances to phylogenetic distance by means of Mantel regression with variance partitioning. Finally, we compared the projection obtained from SDMs fitted from the species level (SDMsp) and composed from the eight clade‐level models (SDMcm).ResultsGenetically and environmentally defined clusters were identical. Environmental and geographical distances explained 12.6% of the phylogenetic distance variation and, overall, geographical and environmental overlap among clades was low. Large differences were detected between SDMsp and SDMcm (57.75% of disagreement in the areas predicted as suitable).Main conclusionsThe genetic structure within the maritime pine subspecies complex is primarily a consequence of its demographic history, as seen by the high proportion of unexplained variation in phylogenetic distances. Nevertheless, our results highlight the contribution of local environmental adaptation in shaping the lower‐order, phylogeographical distribution patterns and spatial genetic structure of maritime pine: (1) genetically and environmentally defined clusters are consistent, and (2) environment, rather than geography, explained a higher proportion of variation in phylogenetic distance. SDMs, key tools in conservation management, better characterize the fundamental niche of the species when they include molecular information.
Cancer and serious mental illness – patient, caregiver and professional perspectives: study protocol
Authors: Millman James , Galway Karen , Santin Olinda , Reid Joanne 
Published: September 2015

AbstractAimTo explore the experience of serious mental illness and cancer from the perspective of patients, significant others and healthcare professionals involved in their care.BackgroundSerious mental illness is associated with poorer cancer outcomes. Those suffering from this comorbidity receive fewer specialist interventions and die earlier than the general population. Prior qualitative research in this area has comprised of a single study focussing on healthcare professionals and there is little evidence regarding the experiences of patients and caregivers.DesignA qualitative exploration using approximately 36 semi‐structured interviews.MethodsSemi‐structured digitally recorded interviews conducted with: adults living with serious mental illness and diagnosed with cancer; those providing them with informal support and care; and healthcare professionals. Questions will focus on the experience of having cancer and serious mental illness or caring for someone with this comorbidity, experiences of healthcare and priorities for patients and carers. Framework analysis will be used. Research Ethics Committee and Trust Research & Development approval was obtained. A steering group comprising six people with experience of either cancer or mental illness provided feedback and ratified the patient information sheets and interview schedules.DiscussionThere is a paucity of research addressing stakeholder perspectives on the experience of cancer and of cancer services for people with serious mental illness. Dissemination of findings will inform practice relating to the care of an often neglected population, informing better support for their significant others and the professionals involved in their care.
Brief report: cervical cancer screening in women with intellectual and developmental disabilities who have had a pregnancy
Authors: Brown H. K. , Plourde N. , Ouellette‐Kuntz H. , Vigod S. , Cobigo V. 
Published: September 2015

AbstractBackgroundWomen with intellectual and developmental disabilities (IDD) have lower cervical cancer screening rates than women without IDD. Key barriers to screening uptake include physician or caregiver assumptions that screening is unnecessary because women with IDD are not sexually active. Our objective was to compare cervical cancer screening rates in women with and without IDD who had had a pregnancy.MethodWe conducted a population‐based retrospective cohort study using linked Ontario (Canada) health and social services administrative data. We identified 20‐ to 64‐year‐old women with (N = 5033) and without (N = 527 437) IDD who had had a pregnancy. We examined the occurrence of cervical cancer screening between April 1, 2007 and March 31, 2010. We compared screening rates in women with and without IDD using logistic regression, controlling for age, region of residence, neighbourhood income quintile and morbidity level.ResultsWomen with IDD who had had a pregnancy were more likely than those without IDD to be young, to live in the lowest neighbourhood income quintile, to live in rural areas and to have high or very high morbidity. Even after controlling for these factors, women with IDD were less likely than women without IDD to be screened (67.7% vs. 77.0%; adjusted odds ratio 0.61; 95% confidence interval 0.58–0.65).ConclusionsEven among women who have had a pregnancy and are therefore known to have been sexually active, women with IDD face significant disparities in cervical cancer screening. Strategies to promote equitable uptake of cervical cancer screening for women with IDD need to be implemented.
Provocation tests for the diagnosis of food‐dependent exercise‐induced anaphylaxis
Authors: Asaumi Tomoyuki , Yanagida Noriyuki , Sato Sakura , Shukuya Akinori , Nishino Makoto , Ebisawa Motohiro 
Published: September 2015

AbstractBackgroundLittle has been reported regarding provocation tests for the diagnosis of food‐dependent exercise‐induced anaphylaxis (FDEIA), especially in children and adolescents. Hence, we here aimed to examine the usefulness and safety of such tests for FDEIA.MethodsWe retrospectively analyzed 41 patients with 184 provocation tests. The patients underwent ergometer stress tests after ingesting the suspected foods along with aspirin. When one or more allergic symptoms appeared, we judged the provocation test as positive.ResultsBased on 30 positive test results (16%), we diagnosed 20 patients (49%) as FDEIA. The major causative foods were as follows: wheat alone (five patients), combination of wheat and shrimp (three patients), combination of wheat and apple (two patients), and peach alone (two patients). The symptoms appeared within 45 min after initiating exercise in 29 tests (97%). The most frequent symptoms were cutaneous symptoms, which appeared in 25 tests (83%). Of the 30 positive tests, 6 (20%) required administration of adrenaline. After discharge, the patients with negative test results had no episodes of FDEIA due to the suspected foods that they had been tested for.ConclusionProvocation tests enabled us to confirm the diagnosis of FDEIA when positive and to exclude the diagnosis when negative. However, as severe symptoms may appear, these tests should be performed in a hospital under constant supervision of a physician.
Global agricultural intensification during climate change: a role for genomics
Authors: Abberton Michael , Batley Jacqueline , Bentley Alison , Bryant John , Cai Hongwei , Cockram James , Costa de Oliveira Antonio , Cseke Leland J. , Dempewolf Hannes , De Pace Ciro , Edwards David , Gepts Paul , Greenland Andy , Hall Anthony E. , Henry Robert , Hori Kiyosumi , Howe Glenn Thomas , Hughes Stephen , Humphreys Mike , Lightfoot David , Marshall Athole , Mayes Sean , Nguyen Henry T. , Ogbonnaya Francis C. , Ortiz Rodomiro , Paterson Andrew H. , Tuberosa Roberto , Valliyodan Babu , Varshney Rajeev K. , Yano Masahiro 
Published: September 2015

SummaryAgriculture is now facing the ‘perfect storm’ of climate change, increasing costs of fertilizer and rising food demands from a larger and wealthier human population. These factors point to a global food deficit unless the efficiency and resilience of crop production is increased. The intensification of agriculture has focused on improving production under optimized conditions, with significant agronomic inputs. Furthermore, the intensive cultivation of a limited number of crops has drastically narrowed the number of plant species humans rely on. A new agricultural paradigm is required, reducing dependence on high inputs and increasing crop diversity, yield stability and environmental resilience. Genomics offers unprecedented opportunities to increase crop yield, quality and stability of production through advanced breeding strategies, enhancing the resilience of major crops to climate variability, and increasing the productivity and range of minor crops to diversify the food supply. Here we review the state of the art of genomic‐assisted breeding for the most important staples that feed the world, and how to use and adapt such genomic tools to accelerate development of both major and minor crops with desired traits that enhance adaptation to, or mitigate the effects of climate change.