bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robotic Mitral Valve Repair for Simple and Complex Degenerative Disease
Authors: Suri Rakesh M. , Taggarse Amit , Burkhart Harold M. , Daly Richard C. , Mauermann William , Nishimura Rick A. , Li Zhuo , Dearani Joseph A. , Michelena Hector I. , Enriquez-Sarano Maurice 
Published: October 2015

Background—
Severe primary (degenerative) mitral regurgitation (MR) is repaired with durable results when simple single-scallop disease is addressed. The midterm quality outcomes of minimally invasive repair for complex disease are unknown, however.

Methods and Results—

From January 2008 to January 2015, 487 patients (56±11 years, 360 men, ejection fraction 65±6%, 98.8% complete follow-up) underwent robotic mitral valve repair for severe nonischemic degenerative MR. Simple pathology was addressed in 289 of 487 (59%) patients, and complex repair (all others) was performed in 198 of 487 (41%). Four patients died during follow-up with a 5-year survival rate 99.5% (99.4% simple; 99.5% complex; hazard ratio, 0.48; 95% confidence interval, 0.05–4.59); and New York Heart Association functional class I/II was documented in 97.9% (477/487). Eight patients had recurrence of moderate-to-severe MR (4 simple, 4 complex), with a 5-year freedom from MR of 94.6% (96.2% simple; 92.7%, complex;
P
=0.67; hazard ratio, 1.36; 95% confidence interval, 0.34–5.43). Seven patients (2 simple, 5 complex), underwent mitral reoperation, with a 5-year freedom from reoperation of 97.7% (99.1% simple; 95.7% complex;
P
=0.13; hazard ratio, 3.35; 95% confidence interval, 0.65–17.32).

Conclusions—
At a large tertiary care referral center, midterm quality outcomes after robotic correction of degenerative MR are excellent, with very high survival, infrequent complications, and a low likelihood of MR recurrence, regardless of mitral valve repair complexity. Awareness of these improvements in outcome is important to inform contemporary decisions regarding high-quality alternatives to conventional and percutaneous mitral repair.
A Few GIS Clarifications on Tornado Density Mapping
Authors: Deng Yongxin , Wallace Brendan , Maassen Derek , Werner Johnathan 
Published: October 2015

AbstractA geographical information system (GIS) perspective is taken to examine conceptual and methodological complications present in tornado density and probability mapping. Tornado density is defined as the inverse-distance-weighted count of tornado touchdown points or tornado-affected cells within a neighborhood area. The paper first adds a few geographic elements into the tornado definition and then characterizes tornado density as a density field in GIS that depends on predefined, modifiable areas to exist. Tornado density is therefore conceptually distinguished from both individual tornadoes and tornado probability. Three factors are identified to be vital in tornado density mapping: the neighborhood size, the distance decay function, and the choice of tornado properties. Correspondingly, 12 neighborhood sizes ranging from 20 to 360 km are tested, four distance decay functions are compared, and two tornado properties—tornado touchdown locations and pathlengths—are separately incorporated in mapping. GIS interpretations, clarifications, and demonstrations are provided for these factors to reach a thorough understanding of how the factors function and affect the resultant tornado density maps. Historical tornado data of the eastern half of the United States from 1973 to 2013 are used in these demonstrations. Uncertainty and propagation analyses are recommended for future tornado density and probability mapping, and a Monte Carlo simulation using tornado pathlength data is conducted as an example of uncertainty modeling. In all, tornado density mapping is diagnosed as a largely subjective activity, and the mapper needs to make multiple choices according to the mapping purpose, scale, and the involved tornado record data.
The M2 Internal Tide Simulated by a 1/10° OGCM
Authors: Li Zhuhua , Storch Jin-Song von , Müller Malte 
Published: October 2015

AbstractUsing a concurrent simulation of the ocean general circulation and tides with the ° Max Planck Institute Ocean Model (MPI-OM), known as STORMTIDE, this study provides a near-global quantification of the low-mode M2 internal tides. The quantification is based on wavelengths and their near-global distributions obtained by applying spectral analysis to STORMTIDE velocities and on comparisons of the distributions with those derived by solving the Sturm–Liouville eigenvalue problem. The simulated wavelengths, with respect to both their magnitudes and their geographical distributions, compare well with those obtained by solving the eigenvalue problem, suggesting that the STORMTIDE internal waves are, to a first approximation, linear internal waves satisfying local dispersion relations. The simulated wavelengths of modes 1 and 2 range within 100–160 and 45–80 km, respectively. Their distributions reveal, to different degrees for both modes, a zonal asymmetry and a tendency of a poleward increase with stratification N and the Coriolis parameter f being responsible for these two features, respectively. Distributions of mode 1 wavelengths are found to be determined by both N and f, but those of mode 2 are mainly controlled by variations in N. Larger differences between the STORMTIDE wavelengths and those of the eigenvalue problem occur, particularly for mode 2, primarily in high-latitude oceans and the Kuroshio and Gulf Stream and their extensions.
The implementation trap: the local level and diversity policies
Authors: Schiller Maria 
Published: October 2015

There is widespread agreement that the local level has become more self-confident and self-reliant in formulating its own immigrant policies and sometimes developing distinct philosophies of immigrant incorporation. However, to date we know little about the actual capacities of cities to implement these philosophies consistently. This article offers a level-specific study of the governance of immigrant incorporation by European municipalities. It focuses on cities with diversity policies and it compares the meaning of diversity in formulated policies with policy implementation. Identifying an implementation gap of diversity policies in Antwerp, Amsterdam and Leeds, it argues that cities may have become more self-reliant and self-confident in coming up with their own ideas and concepts for governing immigration, but this may not mean that they also consistently implement these ideas. This article identifies two explanations for an implementation gap and different capacities across cities to consistently implement such policies. Points for practitioners The article establishes two explanations for the inconsistent implementation of policies, focusing on the case of local diversity policies, and delineates how this plays out across different cities. These findings are relevant as they allow us to define the conditions for consistent policy implementation.
Trigeminal neuralgia (part I): Revisiting the clinical phenotype
Authors: Haviv Y , Khan J , Zini A , Almoznino G , Sharav Y , Benoliel R 
Published: October 2015

Aims We conducted a cross-sectional study to re-examine the clinical profile of patients with a clinical diagnosis of classical trigeminal neuralgia (CTN). Methods Inclusion criteria consisted of the International Headache Society’s published classification of CTN. For the specific purposes of the study, features such as autonomic signs, persistent background pain, attack durations of >2 minutes and reports of pain-related awakening were included. The demographic and clinical phenotype of each patient were carefully recorded for analysis. Results The study cohort consisted of 81 patients and based on reported attack duration these were divided into short (≤ 2 minutes, n = 61) and long (> 2 minutes, n = 20) groups for further analysis. The group with short attack duration neatly fit most of the criteria for CTN while the long attack group presents a more challenging diagnosis. There were no significant differences in pain severity, quality and location between the short and long attack groups. The frequency of persistent background pain was significantly higher in the long (70%) compared to the short attack group (29.5%, p = 0.001). There were significantly more reports of pain-related awakenings in the long (55%) than in the short attack groups (29.5%, p = 0.04). There were no significant differences in the frequency of autonomic signs between the short (21.3%) and long attack groups (40%, p = 0.1). In the short attack group, the presence of autonomic signs was significantly associated with longer disease duration, increased pain-related awakenings, and a reduced prognosis. Conclusion There are clear diagnostic criteria for CTN but often patients present with features, such as long pain attacks, that challenge such accepted criteria. In our cohort the clinical phenotype of trigeminal, neuralgiform pain with or without autonomic signs and background pain was observed across both short and long attack groups and the clinical implications of this are discussed.
Valproic acid improves second-line regimen of small cell lung carcinoma in preclinical models
Authors: Hubaux Roland , Vandermeers Fabian , Cosse Jean-Philippe , Crisanti Cecilia , Kapoor Veena , Albelda Steven M. , Mascaux Céline , Delvenne Philippe , Hubert Pascale , Willems Luc 
Published: October 2015

With 5-year survival rates below 5%, small cell lung carcinoma (SCLC) has very poor prognosis and requires improved therapies. Despite an excellent overall response to first-line therapy, relapses are frequent and further treatments are disappointing. The goal of the study was to improve second-line therapy of SCLC.The effect of chemotherapeutic agents was evaluated in cell lines (apoptosis, reactive oxygen species, and RNA and protein expression) and in mouse models (tumour development).We demonstrate here that valproic acid, a histone deacetylase inhibitor, improves the efficacy of a second-line regimen (vindesine, doxorubicin and cyclophosphamide) in SCLC cells and in mouse models.Transcriptomic profiling integrating microRNA and mRNA data identifies key signalling pathways in the response of SCLC cells to valproic acid, opening new prospects for improved therapies.
Role of Chemoradiotherapy in Elderly Patients With Limited-Stage Small-Cell Lung Cancer
Authors: Corso Christopher D. , Rutter Charles E. , Park Henry S. , Lester-Coll Nataniel H. , Kim Anthony W. , Wilson Lynn D. , Husain Zain A. , Lilenbaum Rogerio C. , Yu James B. , Decker Roy H. 
Published: October 2015

Purpose To investigate outcomes for elderly patients treated with chemotherapy (CT) alone versus chemoradiotherapy (CRT) in the modern era by using a large national database. Patients and Methods Elderly patients (age ≥ 70 years) with limited-stage small-cell lung cancer clinical stage I to III who received CT or CRT were identified in the National Cancer Data Base between 2003 and 2011. Hierarchical mixed-effects logistic regression with clustering by reporting facility was performed to identify factors associated with treatment selection. Overall survival (OS) of patients receiving CT versus CRT was compared by using the log-rank test, Cox proportional hazards regression, and propensity score matching. Results A total of 8,637 patients were identified, among whom 3,775 (43.7%) received CT and 4,862 (56.3%) received CRT. The odds of receiving CRT decreased with increasing age, clinical stage III disease, female sex, and the presence of medical comorbidities (all P < .01). Use of CRT was associated with increased OS compared with CT on univariable and multivariable analysis (median OS, 15.6 v 9.3 months; 3-year OS, 22.0% v 6.3%; log-rank P < .001; Cox P < .001). Propensity score matching identified a matched cohort of 6,856 patients and confirmed a survival benefit associated with CRT (hazard ratio, 0.52; 95% CI, 0.50 to 0.55; P < .001). Subset analysis of CRT treatment sequence showed that patients alive 4 months after diagnosis derived a survival benefit with concurrent CRT over sequential CRT (median OS, 17.0 v 15.4 months; log-rank P = .01). Conclusion In elderly patients with limited-stage small-cell lung cancer, modern CRT appears to confer an additional OS advantage beyond that achieved with CT alone in a large population-based cohort. Our findings suggest that CRT should be the preferred strategy in elderly patients who are expected to tolerate the toxicities of the combined approach.
The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice
Authors: Ceddia Ryan P. , Lee DaeKee , Maulis Matthew F. , Carboneau Bethany A. , Threadgill David W. , Poffenberger Greg , Milne Ginger , Boyd Kelli L. , Powers Alvin C. , McGuinness Owen P. , Gannon Maureen , Breyer Richard M. 
Published: October 2015

AbstractMice carrying a targeted disruption of the prostaglandin E2 (PGE2) E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted PGE2-EP3 signaling on diabetes in a setting of diet-induced obesity. Although no differences in body weight were seen in mice fed the control diet, when fed a HFD, EP3−/− mice gained more weight relative to EP3+/+ mice. Overall, EP3−/− mice had increased epididymal fat mass and adipocyte size; paradoxically, a relative decrease in both epididymal fat pad mass and adipocyte size was observed in the heaviest EP3−/− mice. The EP3−/− mice had increased macrophage infiltration, TNF-α, monocyte chemoattractant protein-1, IL-6 expression, and necrosis in their epididymal fat pads as compared with EP3+/+ animals. Adipocytes isolated from EP3+/+ or EP3−/− mice were assayed for the effect of PGE2-evoked inhibition of lipolysis. Adipocytes isolated from EP3−/− mice lacked PGE2-evoked inhibition of isoproterenol stimulated lipolysis compared with EP3+/+. EP3−/− mice fed HFD had exaggerated ectopic lipid accumulation in skeletal muscle and liver, with evidence of hepatic steatosis. Both blood glucose and plasma insulin levels were similar between genotypes on a control diet, but when fed HFD, EP3−/− mice became hyperglycemic and hyperinsulinemic when compared with EP3+/+ fed HFD, demonstrating a more severe insulin resistance phenotype in EP3−/−. These results demonstrate that when fed a HFD, EP3−/− mice have abnormal lipid distribution, developing excessive ectopic lipid accumulation and associated insulin resistance.
Torsion in tensor powers of modules
Authors: Celikbas Olgur , Iyengar Srikanth B. , Piepmeyer Greg , Wiegand Roger 
Published: October 2015

AbstractTensor products usually have nonzero torsion. This is a central theme of Auslander's 1961 paper; the theme continues in the work of Huneke and Wiegand in the 1990s. The main focus in this article is on tensor powers of a finitely generated module over a local ring. Also, we study torsion-free modules N with the property that M ⊗R N has nonzero torsion unless M is very special. An important example of such a module N is the Frobenius power peR over a complete intersection domain R of characteristic p > 0.
Isolation and screening of rhizobacteria from soil in Ngawi, East Java,as candidates of agent for liquid organic fertilizer production
Authors: IMAMUDDIN HARTATI , DEWI TIRTA KUMALA , ANTONIUS SARJIYA 
Published: October 2015

Abstract. Imamuddin H, Dewi TK, Antonius S. 2015. Isolation and screening of rhizobacteria from soil in Ngawi, East Java as candidates of agent for liquid organic fertilizer production. Nusantara Bioscience 7: 107-111. A series of activities have been done to find indigenous microbes from Ngawi, East Java, as candidates for living organic fertilizers. The study was started with sampling of soils from 17 locations in Ngawi. Then, the samples were isolated to get population of soil microbes, including total, phosphate-solubilizing, N-fixing, and IAA-(Indol Acetic Acid)-producing bacteria. Five soil samples were used to test bacterial growth in several concentration of propoxur. Method of isolation used in this study was enrichment culture and the growth was determined using spectrophotometer at 436 nm wave length. The resuts showed that the populations of total and IAA-producing bacteria in Ngawi soil were relatively high, namely 106 CFU/g soil, but the population N-fixing bacteria was only 10-5, and no phosphate-solubilizing bacteria could grow. Twenty one isolates of bacteria were found, 16 of which postively produced IAA and 5 isolates of which could grow in propoxur medium. The highest production of IAA was found in sample number 6.3 with a concentration of 123.535 ppm and isolate H-2-NG (sample number 2) could grow at concentration of 1000 ppm (MM medium)-3000 ppm (MSB medium). It is hoped that these isolates can be used as candidates of agent for liquid living organic fertilizers.
Planar Functionalized Surfaces for Direct Immunoaffinity Desorption/Ionization Mass Spectrometry
Authors: Pompach Petr , Nováková Jana , Kavan Daniel , Benada Oldřich , Růžička Viktor , Volný Michael , Novák Petr 
Published: October 2015

Abstract

BACKGROUND
Recent studies show that the haptoglobin phenotype in individuals with diabetes mellitus is an important factor for predicting the risk of myocardial infarction, cardiovascular death, and stroke. Current methods for haptoglobin phenotyping include PCR and gel electrophoresis. A need exists for a reliable method for high-throughput clinical applications. Mass spectrometry (MS) can in principle provide fast phenotyping because haptoglobin α 1 and α 2, which define the phenotype, have different molecular masses. Because of the complexity of the serum matrix, an efficient and fast enrichment technique is necessary for an MS-based assay.

METHODS
MALDI plates were functionalized by ambient ion landing of electrosprayed antihaptoglobin antibody. The array was deposited on standard indium tin oxide slides. Fast immunoaffinity enrichment was performed in situ on the plate, which was further analyzed by MALDI-TOF MS. The haptoglobin phenotype was determined from the spectra by embedded software script.

RESULTS
The MALDI mass spectra showed ion signals of haptoglobin α subunits at m/z 9192 and at m/z 15 945. A cohort of 116 sera was analyzed and the reliability of the method was confirmed by analyzing the identical samples by Western blot. One hundred percent overlap of results between the direct immunoaffinity desorption/ionization MS and Western Blot analysis was found.

CONCLUSIONS
MALDI plates modified by antihaptoglobin antibody using ambient ion landing achieve low nonspecific interactions and efficient MALDI ionization and are usable for quick haptoglobin phenotyping.
Investigation of writing tendencies of secondary school students with regards to various variables<p>Ortaokul öğrencilerinin yazma eğilimlerinin farklı değişkenler açısından incelenmesi
Authors: Kana Fatih , Özbaşı Durmuş , Ünlü Süleyman 
Published: October 2015

<p>The purpose of this study is to investigate writing tendencies of secondary school students with regards to different variables. Descriptive survey model was used in the study to find out students’ general writing tendencies. Writing Tendency Inventory which was adapted into Turkish by İşeri and Ünal (2010) and which has 21 items, was used in this study. The sampling of this study consists of 1145 secondary school students in 2013-2014 academic year. T-test and one-way variance analysis were used in the analysis of the collected data in this study. The findings of this study reveal that there has been a significant difference in students’ writing tendencies depending on their classes, gender, their state of keeping or not keeping a diary, the number of the books that they read in the former year, the reading group that they feel they belong to and the state of their liking or not liking to read. As a conclusion of the study, it can be suggested that secondary students’ writing tendencies (with regards to reliance, passion and continuity sub-dimensions) are higher at first years compared to other classes (especially at the 5th year) and they have more tendency to write. Besides, female students were found to have higher writing tendencies, and it can also be suggested that writing tendency is closely related to the number of read books, the state of keeping or not keeping a diary or the state of liking or not liking to read.</p><p> </p><p><strong>Özet</strong></p><p>Bu çalışmanın amacı ortaokul öğrencilerinin yazma eğilimlerini çeşitli değişkenler açısından incelemektir. Araştırma öğrencilerin genel yazma eğilimlerinin araştırılması bakımından betimsel türde tarama modelinde bir araştırmadır. Çalışmada öğrencilerin okuma yazma eğilimlerini tespit etmek amacıyla İşeri ve Ünal (2010) tarafından Türkçe ’ye uyarlanan 21 maddeden oluşan yazma eğilimi ölçeği kullanılmıştır. Araştırmanın çalışma grubunu 2013-2014 eğitim öğretim yılında öğrenim görmekte olan 1145 ortaokul öğrencisi oluşturmaktadır. Verilerin analizinde t-testi ve tek yönlü varyans analizi kullanılmıştır. Araştırmanın bulgularına göre, öğrencilerin yazma eğilimleri okudukları sınıf, cinsiyet, günlük tutup tutmamaları, son bir yıl içerisinde okudukları kitap sayısı, kendilerini hissettikleri okuyucu grubu, yazmayı sevip sevmedikleri bakımından anlamlı fark bulunmuştur. Çalışmanın sonucu olarak, yazma eğilimi (güven, tutku ve süreklilik alt boyutlarında) ortaokul öğrencilerinin ilk yıllarında (özellikle beşinci sınıfta) diğer sınıflara göre daha yüksek olduğu, öğrencilerin yazmaya daha yatkın olduğu söylenebilir. Ayrıca kız öğrencilerin yine yazma eğilimlerinin daha yüksek odluğu; yazma eğiliminde okunan kitap sayısının, günlük tutmanın ve yazmayı sevmenin etkili olduğu araştırma sonucuna söylenebilir.</p>
Understanding entry and exit: a business cycle accounting approach
Authors: Macnamara Patrick 
Published: October 2015

AbstractThis paper considers a model of firm dynamics to study how well aggregate shocks account for fluctuations in the entry and exit of establishments. To do this, I construct measures of aggregate technology, labor and investment shocks. Under reasonable parameters, the model indicates that labor shocks (and not technology or investment shocks) best account for cyclical fluctuations in entry and exit rates. Moreover, this has had significant implications for the aggregate economy, as entry and exit have made output and hours more volatile and persistent.
Optimization of Nickel Chemical Extraction from Hazardous Residue
Authors: Gharabaghi Mahdi , Azadmehr Amirreza 
Published: October 2015

Abstract
Statistical design of experiments was used for design and analysis of nickel extraction from hazardous waste. Sulphuric acid leaching of zinc plant residue has been performed for monitoring and evaluating the effects of process factors on the nickel leaching yield. Factorial design was planned first in order to study the effect of six process factors and screen main variables. These factors were reaction time, acid concentration, solid-liquid ratio % (w/v), particle size, stirring speed and reaction temperature. The main factors and their interaction were studied by analysis of variance (ANOVA), and the results showed that the reaction time, acid concentration and solid-liquid ratio were the most significant factors. In the second set of experiments, response surface methodology (RSM) was used for modelling and optimisation of significant factors. Quadratic model was derived for the prediction of nickel extraction. The optimum values for maximum nickel was identified to be a leaching time of 30 min, acid concentration 10% (V/V) and solid liquid ratio of 10%. Using these optimum conditions, more than 94% nickel was extracted. In addition the results of model equation showed a good agreement with the experimental data.