bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Four-Year Follow-up Study of Renal Epithelioid Angiomyolipoma: A Multi-Center Experience and Literature Review
Authors: Lei Jun H. , Liu Liang R. , Wei Qiang , Song Tu R. , Yang Lu , Yuan Hai C. , Jiang Yong , Xu Huan , Xiong Sheng H. , Han Ping 
Published: May 2015

AbstractIn this study, we systematically explored the clinical manifestations, diagnosis, treatment and prognosis of renal epithelioid angiomyolipoma (EAML) retrospectively by analyzing data of 52 patients diagnosed with EAML at four centers. Our results showed that the onset of EAML was usually inconspicuous and so no obvious symptoms or signs had occurred in most patients at diagnosis. Its diagnoses always depended on postoperative pathological examination. The immunohistochemical (IHC) results [HMB45 ( + ), cytokeratin (-) and S100 (-)] could be used to differentiate EAML from other malignancies such as renal cell cancer (RCC) and sarcomas. For treatment, surgery resulted in satisfactory short-term prognosis. The long-term prognosis of patients with EAML was poor, particularly when a large size, a high percentage of epithelioid component, tumor thrombus formation and necrosis were present. In conclusion, EAML is a tumor with malignant potential. Once diagnosed, integrated approaches, including surgery, chemotherapy and targeted therapy, should be considered; a close follow-up regimen is necessary for cases that met: 1) tumor size >9 cm, 2) tumor thrombus formation in the vein, 3) epithelioid cells >70% or atypia cells >60% and 4) necrosis.
Comparison of Saline-Irrigated Catheter vs. Temperature-Controlled Catheter for Renal Denervation in a Canine Model
Authors: Wang Zhenglong , Chen Shaojie , Zhou Tingquan , Su Li , Ling Zhiyu , Fan Jinqi , Chen Weijie , Du Huaan , Lu Jiayi , Xu Yanping , Tan Zhen , Yang Hanxuan , Hu Xinyu , Li Chengzhi , Yan Xue , Hu Guangxin , Liu Chang , Yin Yuehui 
Published: May 2015

BACKGROUND
The effectiveness of catheter-based renal denervation (RDN) remains controversial. Although the reasons for this have not yet been elucidated, ineffective denervation appears to be an important factor. The present study aimed to investigate the difference in RDN between a saline-irrigated catheter (SIC) and a temperature-controlled catheter (TCC).

METHODS
Dogs (n = 6) from the Kunming province in Chinese were ablated; the SIC was introduced into the right renal artery, while the TCC was introduced into the left renal artery. After 6 months, histopathology and renal angiography were performed, and the change in neural density was evaluated using morphometric software. The average values of heart rate (HR), blood pressure (BP), and catecholamine metabolites were assessed at baseline and follow-up.

RESULTS
Histopathology showed nerve demyelination and denaturation, as well as interstitial hyperplasia, although these changes were more pronounced when the SIC was used. The change in neural density was greater and ablation was deeper when the SIC was used. Intimal hyperplasia was greater when the TCC was used, whereas medial hyperplasia was greater when the SIC was used. A trend toward a decrease in HR, BP, metanephrine, and normetanephrine between baseline and follow-up was observed.

CONCLUSIONS
Our findings suggest that SIC ablation results in more extensive neural degeneration, deeper penetration, and less extensive intimal hyperplasia than TCC ablation for RDN.
The Early Career of William of Ypres in England: A New Charter of King Stephen
Authors: Nieus Jean-François 
Published: May 2015

Abstract
The abstract for your paper is included below. This will appear online only. This article discusses a newly discovered writ addressed by King Stephen to his military commander and leading supporter William of Ypres. This undated writ, copied by the French antiquary Étienne Baluze from a twelfth-century cartulary of the abbey of Saint-Bertin in northern France, was most probably issued in or around 1140. It sheds interesting new light on the English holdings of Stephen of Blois before his coronation, as well as on the (poorly documented) early career of William of Ypres in service to the new king. It records a grant to William of two knight’s fees in Suffolk, along with the port of Orford, which, as we learn from the text, had been previously awarded to Stephen by King Henry I. Orford was indeed associated with the honour of Eye, held by Stephen after 1113–5 and—as we can now confirm—transferred to William’s own custody around 1137. It mattered to both men as a strategic sea connection between East Anglia and their continental interests, i.e. the county of Boulogne and the recruitment area of Flemish mercenaries. This is probably why William retained it after his appointment in Kent around 1139. William of Ypres’ early tenancy in Eye eventually helps us to reassess his traditional image as a ‘mercenary captain’, and gives new insight into King Stephen’s administrative reforms on the eve of the civil war.
Pre-release processes influencing short-term mortality of glass eels in the French eel (Anguilla anguilla, Linnaeus 1758) stocking programme
Authors: Josset Q. , Trancart T. , Mazel V. , Charrier F. , Frotté L. , Acou A. , Feunteun E. 
Published: May 2015

Abstract
The decline in the European eel has led the European Union to require that its Member States establish an Eel Management Plan, which includes a set of measures to help preserve and restore the wild eel populations. Stocking has been conducted in France since 2011 as part of this Management Plan. This stocking programme is based on a protocol designed by the French National Museum of Natural History and includes an assessment of the short-term (15 d after release) mortality and three recapture surveys at 6, 12, and 36 months after release. The present study aims to assess the different processes influencing the short-term mortality to provide recommendations to reduce mortality and increase the efficiency of the releases. A linear model was built to examine the different variables selected modelling. The resulting model explained 56.4% of the total deviance; the main factor in terms of explained deviance was the operation (31.2%), which actually includes a number of handling parameters. The other factors influencing the short-term mortality were the release year, the fishmonger that provided the glass eels, the duration of stalling (period of captivity) before release, the body condition, the marking, and the type of mortality test. It appears that some of these variables could be adjusted to reduce the short-term mortality. For instance, selecting the most suitable release sites to stock or selecting glass eels with good body condition, adjusting the duration of stalling, or limiting the marking should help reduce short-term mortality.
Reactivation of Chagas Disease in a Patient With Follicular Lymphoma Diagnosed by Means of Quantitative Real-Time Polymerase Chain Reaction
Authors: Garzón Maria I. , Sánchez Ariel G. , Goy Maria C. , Alvarellos Teresita , Zarate Abel H. , Basquiera Ana L. , Garcia Juan J. , Caeiro Juan P. 
Published: May 2015

Abstract
We report a case of Chagas disease reactivation in a patient with stage IIb follicular lymphoma in the cecum. He was admitted to the hospital with neutropenia and fever. He had a history of right hemicolectomy 6 months earlier and had received the sixth cycle of chemotherapy with cyclophosphamide/doxorubicin/vincristine/prednisone/rituximab. Blood and urine cultures were negative, but the fever persisted. Reactivation of Chagas disease was confirmed by means of quantitative real-time polymerase chain reaction (qRT-PCR). Parasitic load was 577 950 parasite equivalents/mL. The patient began treatment with benznidazole 5 mg/k per day every 12 hours. After 1 month, the qRT-PCR control was undetectable. The patient completed 60 days of treatment and is currently asymptomatic. Trypanosoma cruzi qRT-PCR may become a useful diagnostic method for reactivation of Chagas disease.
Increased Regulatory T-Cell Percentage Contributes to Poor CD4+ Lymphocytes Recovery: A 2-Year Prospective Study After Introduction of Antiretroviral Therapy
Authors: Saison Julien , Maucort Boulch Delphine , Chidiac Christian , Demaret Julie , Malcus Christophe , Cotte Laurent , Poitevin-Later Francoise , Miailhes Patrick , Venet Fabienne , Trabaud Mary Anne , Monneret Guillaume , Ferry Tristan 
Published: May 2015

Abstract
Background.  The primary aim of this study was to determine the impact of regulatory T cells (Tregs) percentage on immune recovery in human immunodeficiency virus (HIV)-infected patients after antiretroviral therapy introduction.
Methods.  A 2-year prospective study was conducted in HIV-1 chronically infected naive patients with CD4 count &lt;500 cells/mm3. Regulatory T cells were identified as CD4+CD25highCD127low cells among CD4+ lymphocytes. Effect of Treg percentage at inclusion on CD4 evolution overtime was analyzed using a mixed-effect Poisson regression for count data.
Results.  Fifty-eight patients were included (median CD4 = 293/mm3, median Treg percentage = 6.1%). Percentage of Treg at baseline and CD4 nadir were independently related to the evolution of CD4 absolute value according to time: (1) at any given nadir CD4 count, 1% increase of initial Treg was associated with a 1.9% lower CD4 absolute value at month 24; (2) at any given Treg percentage at baseline, 10 cell/mm3 increase of CD4 nadir was associated with a 2.4% increase of CD4 at month 24; and (3) both effects did not attenuate with time. The effect of Treg at baseline on CD4 evolution was as low as the CD4 nadir was high.
Conclusions.  Regulatory T-cell percentage at baseline is a strong independent prognostic factor of immune recovery, particularly among patients with low CD4 nadir.
Securities and Exchange Commission announces enforcement initiative directed at reporting violations by public company insiders
Authors: Parrino Richard J. , Romeo Peter , Dye Alan 
Published: May 2015

Purpose
– The purpose of this paper is to review the enforcement initiative announced by the US Securities and Exchange Commission (SEC) in September 2014 directed at reporting violations of the Securities Exchange Act of 1934 (Exchange Act) by public company officers, directors and significant stockholders. The paper considers the notable features of the first round of SEC enforcement actions pursuant to that initiative and proposes measures public companies and their insiders can adopt to enhance compliance with their reporting and related disclosure obligations under the Exchange Act.

Design/methodology/approach
– The paper examines the SEC’s enforcement initiative against the backdrop of the agency’s enforcement activity since 1990 for violations by public company insiders of the reporting provisions of Sections 13 and 16 of the Exchange Act. The paper summarizes the features of the reporting violations that attracted SEC enforcement interest in the recent proceedings and identifies the factors apparently weighed by the SEC in determining the amount of the penalties sought against those charged with the violations.

Findings
– The SEC’s latest enforcement actions are unprecedented for insider reporting violations. The new enforcement initiative represents an abandonment by the SEC of its largely passive approach of the past dozen years in which it charged insider reporting violations only when they related to fraud or other major violations of the securities laws. If reporting violations are flagrant, the SEC now promises to target the offenders for enforcement on a stand-alone basis without regard to other possible wrongdoing. The SEC also cautions that, as it did in some of the recent enforcement actions, it may charge companies that promise to assist their insiders in the preparation and filing of their reports, but do not to make the filings in a timely manner, with contributing to the filing failures.

Originality/value
– The paper provides expert guidance from experienced securities lawyers.
Perceived organizational support and its outcomes
Authors: Ahmed Ishfaq , Nawaz Muhammad Musarrat , Ali Ghulam , Islam Talat 
Published: May 2015

Purpose– Riggleet al.’s (2009) research of 20 years literature (1986-2006) is the latest available meta-analysis on perceived organizational support and outcomes. There are seven years since no work has been done to see the changes in the research and its emphasis, which is the main target of this research. This study aimed at five major outcomes: employee engagement, job satisfaction, organizational commitment, organizational citizenship behavior and turnover intentions.Design/methodology/approach– Hundred and twelve studies were included in meta-analysis containing at least one of the outcomes. Riggleet al.included 167 studies in their investigation from 1986 to 2006. This study adds value to the work of Riggleet al.by looking at the studies conducted from January 2007 to April 2014.Findings– Findings of the study revealed that perceived organizational support had a strong positive impact on employee engagement, job satisfaction and organizational commitment, while its impact on organizational citizenship behavior and turnover intentions is moderate.Originality/value– This study adds value by offering meta-analysis of the perceived organizational support and its outcomes for latest available literature (i.e. 2007-2014).
Seasonal demography of a cyclic lemming population in theCanadianArctic
Authors: Fauteux Dominique , Gauthier Gilles , Berteaux Dominique 
Published: May 2015

SummaryThe causes of cyclical fluctuations in animal populations remain a controversial topic in ecology. Food limitation and predation are two leading hypotheses to explain small mammal population dynamics in northern environments. We documented the seasonal timing of the decline phases and demographic parameters (survival and reproduction) associated with population changes in lemmings, allowing us to evaluate some predictions from these two hypotheses.We studied the demography of brown lemmings (Lemmus trimucronatus), a species showing 3‐ to 4‐year population cycles in the Canadian Arctic, by combining capture–mark–recapture analysis of summer live‐trapping with monitoring of winter nests over a 10‐year period. We also examined the effects of some weather variables on survival.We found that population declines after a peak occurred between the summer and winter period and not during the winter. During the summer, population growth was driven by change in survival, but not in fecundity or proportion of juveniles, whereas in winter population growth was driven by changes in late summer and winter reproduction.We did not find evidence for direct density dependence on summer demographic parameters, though our analysis was constrained by the paucity of data during the low phase. Body mass, however, was highest in peak years.Weather effects were detected only in early summer when lemming survival was positively related to snow depth at the onset of melt but negatively related to rainfall.Our results show that high mortality causes population declines of lemmings during summer and fall, which suggests that predation is sufficient to cause population crashes, whereas high winter fecundity is the primary factor leading to population irruptions. The positive association between snow depth and early summer survival may be due to the protective cover offered by snow against predators. It is still unclear why reproduction remains low during the low phase.
Citrinin Determination in Red Fermented Rice Products by Optimized Extraction Method Coupled to Liquid Chromatography Tandem Mass Spectrometry (LC‐MS/MS)
Authors: Ji Xiaofeng , Xu Junfeng , Wang Xiaofu , Qi Peipei , Wei Wei , Chen Xiaoyun , Li Rui , Zhou Yu 
Published: May 2015

AbstractA rapid and sensitive method was developed and validated for citrinin determination in red fermented rice products by liquid chromatography tandem mass spectrometry (LC‐MS/MS) under the selected reaction monitoring mode. Sample preparation was especially focused, and the quantitative methods of LC‐MS/MS and high‐performance liquid chromatography with fluorescence detection (HPLC‐FLD) were compared. In red fermented rice samples, the limit of detection was 1.0 μg/kg for LC‐MS/MS compared to 250 μg/kg for HPLC‐FLD, the limit of quantification was 3.0 μg/kg for LC‐MS/MS compared to 825 μg/kg for HPLC‐FLD. High correlation coefficient was obtained (R2 = 0.999) within the linear range (0.1 to 100 μg/L) in the MS method. The recoveries ranging from 80.9% to 106.5% were obtained in different spiking concentrations. The average intra‐ and inter‐day accuracy ranged from 75.4% to 103.1%, and the intra‐ and inter‐day precisions were from 3.3% to 7.9%. The developed method was applied to 12 commercial red fermented rice products, and citrinin was found in 10 samples ranging from 0.14 to 44.24 mg/kg. Compared to traditional qualitative and quantitative methods, the newly developed LC‐MS/MS method for citrinin determination includes the merits of using a small amount of extraction solvent, simple preparation steps, and high sensitivity.
Violent suicidal behaviour in bipolar disorder is associated with nitric oxide synthase 3 gene polymorphism
Authors: Oliveira J. , Debnath M. , Etain B. , Bennabi M. , Hamdani N. , Lajnef M. , Bengoufa D. , Fortier C. , Boukouaci W. , Bellivier F. , Kahn J.‐P. , Henry C. , Charron D. , Krishnamoorthy R. , Leboyer M. , Tamouza R. 
Published: May 2015

ObjectiveGiven the importance of nitric oxide system in oxidative stress, inflammation, neurotransmission and cerebrovascular tone regulation, we postulated its potential dysfunction in bipolar disorder (BD) and suicide. By simultaneously analysing variants of three isoforms of nitric oxide synthase (NOS) genes, we explored interindividual genetic liability to suicidal behaviour in BD.MethodA total of 536 patients with BD (DSM‐IV) and 160 healthy controls were genotyped for functionally relevant NOS1, NOS2 and NOS3 polymorphisms. History of suicidal behaviour and violent suicide attempt was documented for 511 patients with BD. Chi‐squared test was used to perform genetic association analyses and logistic regression to test for gene–gene interactions.ResultsNOS3 rs1799983 T homozygous state was associated with violent suicide attempts (26.4% vs. 10.8%, in patients and controls, P = 0.002, corrected P (Pc) = 0.004, OR: 2.96, 95% CI = 1.33–6.34), and this association was restricted to the early‐onset BD subgroup (37.9% vs. 10.8%, in early‐onset BD and controls, P = 0.0003, Pc = 0.0006 OR: 5.05, 95% CI: 1.95–12.45), while we found no association with BD per se and no gene–gene interactions.ConclusionOur results bring further evidence for the potential involvement of endothelial NOS gene variants in susceptibility to suicidal behaviour. Future exploration of this pathway on larger cohort of suicidal behaviour is warranted.
Owned dog and cat populations in remote Indigenous communities in the Northern Territory: a retrospective study
Authors: Burleigh A , McMahon S , Kiely S 
Published: May 2015

ObjectiveTo determine the population of owned dogs and cats in Indigenous communities in the Northern Territory (NT), and compare the data with those for the average Australian household.MethodsResults of 20 Indigenous community animal health programs were analysed for species present and dog and cat numbers. The female breeding and puppy populations were also identified.ResultsThe average dog population density was significantly higher than the average Australian household, with an average of 24.4 dogs per 10 households, but the average cat population density was similar (3.3 cats per 10 households). Numbers of other species were not determined. The average percentage of puppies in these communities was 17.6% of the treated canine population, the average percentage of breeding canine females was 18.6% of the treated canine population, and the average percentage of breeding feline females was 19.7% of the total feline population.ConclusionsDog populations in NT Indigenous communities were at least 6.3‐fold higher per household compared with data for the rest of Australia. Cat populations per household were similar to the overall population. Factors contributing to the relatively high dog populations in remote Indigenous communities include a lack of veterinary presence, community remoteness, poor socioeconomic factors, poor house and yard designs, cultural reasons, communal beliefs, lack of community animal management and a lack of funding. We believe that animal health programs are an important way of addressing a number of these issues. Other elements that should be addressed include improving house and yard design, increasing education regarding animal health, care and welfare, and increasing the training and presence of health and animal professionals.
Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model
Authors: Gassner Franz J. , Zaborsky Nadja , Catakovic Kemal , Rebhandl Stefan , Huemer Michael , Egle Alexander , Hartmann Tanja N. , Greil Richard , Geisberger Roland 
Published: May 2015

SummaryAlthough chronic lymphocytic leukaemia (CLL) is a B cell malignancy, earlier studies have indicated a role of T cells in tumour growth and disease progression. In particular, the functional silencing of antigen‐experienced T cells, called T cell exhaustion, has become implicated in immune evasion in CLL. In this study, we tested whether T cell exhaustion is recapitulated in the TCL1tg mouse model for CLL. We show that T cells express high levels of the inhibitory exhaustion markers programmed cell death 1 (PDCD1, also termed PD‐1) and lymphocyte‐activation gene 3 (LAG3), whereas CLL cells express high levels of CD274 (also termed PD‐ligand 1). In addition, the fraction of exhausted T cells increases with CLL progression. Finally, we demonstrate that exhausted T cells are reinvigorated towards CLL cytotoxicity by inhibition of PDCD1/CD274 interaction in vivo.These results suggest that T cell exhaustion contributes to CLL pathogenesis and that interference with PDCD1/CD274 signalling holds high potential for therapeutic approaches.