bluuebunny/crossref_metadata_2025_split huggingface dataset:
R-CHOP with dose-attenuated radiation therapy could induce good prognosis in gastric diffuse large B cell lymphoma
Authors: Mishima Yuko , Terui Yasuhito , Yokoyama Masahiro , Nishimura Noriko , Sakajiri Sakura , Ueda Kyoko , Kuboki Yasutoshi , Nakano Kenji , Suzuki Kazuhito , Nara Eriko , Tsuyama Naoko , Takeuchi Kengo , Oguchi Masahiko , Hatake Kiyohiko 
Published: September 2012

Abstract

Background
The treatment strategy for gastric diffuse large cell lymphoma (DLBCL) has not been standardized in such as to the cycles of chemotherapy, dose of radiation, or necessity for the surgery. Although the results of CHOP or R-CHOP treatments have demonstrated the good prognosis, the treatments have been controversial in many cases.

Methods
We retrospectively analyzed 40 gastric DLBCL patients receiving chemotherapy with or without radiation in our institute. Those in stages II-IV were treated with six cycles of R-CHOP without radiation; for those in stage I, we administered three cycles of R-CHOP with radiation.

Results
The three-year overall survival (OS) and progression-free survival (PFS) rates were 95.2 and 91.8%, respectively. Those in stage I obtained 100% of OS. The radiation dose prescribed was 30.6 Gy for CR cases and 39.6 to 40 Gy for PR after chemotherapy. Although survival rates tended to correlate with staging groups or age-adjusted IPI classifications, multivariate statistical analysis did not show clear differences. All 14 patients with initial bleeding were successfully managed without surgery during treatment.

Conclusion
R-CHOP therapy was very effective for gastric DLBCL. It may be not necessary to use more than 30.6 Gy of radiotherapy in the highly chemo-sensitive cases. Less toxic treatments should be made available to gastric DLBCL patients.
The removal of acetabular bone in hip resurfacing and cementless total hip replacement
Authors: Cross M. B. , Dolan M. M. , Sidhu G. S. , Nguyen J. , Mayman D. J. , Su E. P. 
Published: September 2012

The purpose of this study was to compare the amount of acetabular bone removed during hip resurfacing (HR) and cementless total hip replacement (THR), after controlling for the diameter of the patient’s native femoral head. Based on a power analysis, 64 consecutive patients (68 hips) undergoing HR or THR were prospectively enrolled in the study. The following data were recorded intra-operatively: the diameter of the native femoral head, the largest reamer used, the final size of the acetabular component, the size of the prosthetic femoral head and whether a decision was made to increase the size of the acetabular component in order to accommodate a larger prosthetic femoral head. Results were compared using two-sided, independent samples Student’s t-tests. A statistically significant difference was seen in the mean ratio of the size of the acetabular component to the diameter of the native femoral head (HR: 1.05 (sd 0.04) versus THR: 1.09 (sd 0.05); p < 0.001) and largest acetabular reamer used to the diameter of the native femoral head (HR: 1.03 (sd 0.04) versus THR: 1.09 (sd 0.05); p < 0.001). The ratios varied minimally when the groups were subdivided by gender, age and obesity. The decision to increase the size of the acetabular component to accommodate a larger femoral head occurred more often in the THR group (27% versus 9%). Despite the emphasis on avoiding damage to the femoral neck during HR, the ratio of the size of the acetabular component to the diameter of the native femoral head was larger in cementless THR than in HR.
Array-Based Karyotyping in Plasma Cell Neoplasia After Plasma Cell Enrichment Increases Detection of Genomic Aberrations
Authors: Zehentner Barbara K. , Hartmann Luise , Johnson Krystal R. , Stephenson Christine F. , Chapman Douglas B. , de Baca Monica E. , Wells Denise A. , Loken Michael R. , Tirtorahardjo Budi , Gunn Shelly R. , Lim Lony 
Published: September 2012

Abstract
The discovery of genomic abnormalities present in monoclonal plasma cells has diagnostic, prognostic, and disease-monitoring implications in plasma cell neoplasms (PCNs). However, technical and disease-related limitations hamper the detection of these abnormalities using cytogenetic analysis or fluorescence in situ hybridization (FISH). In this study, 28 bone marrow specimens with known PCNs were examined for the presence of genomic abnormalities using microarray analysis after plasma cell enrichment. Cytogenetic analysis was performed on 15 of 28 samples, revealing disease-related genomic aberrations in only 3 (20%) of 15 cases. FISH analysis was performed on enriched plasma cells and detected aberrations in 84.6% of specimens while array comparative genomic hybridization (aCGH) detected abnormalities in 89.3% of cases. Furthermore, aCGH revealed additional abnormalities in 24 cases compared with FISH alone. We conclude that aCGH after plasma cell enrichment, in combination with FISH, is a valuable approach for routine clinical use in achieving a more complete genetic characterization of patients with PCN.
Elastin peptides in aging and pathological conditions
Authors: Baud Stéphanie , Duca Laurent , Bochicchio Brigida , Brassart Bertrand , Belloy Nicolas , Pepe Antonietta , Dauchez Manuel , Martiny Laurent , Debelle Laurent 
Published: September 2012

AbstractElastin is the protein responsible for the resilience of vertebrate tissue. It is an extremely stable protein deposited during the early stages of life and experiencing almost no renewal. As a consequence, it can be considered that each individual has an elastin capital for life. Despite its extreme stability, elastin can be degraded by several enzymes termed elastases. Elastases are among the most aggressive proteases, and their presence is increased with age. As a consequence, elastin fragmentation resulting in the generation of elastin peptides is one of the hallmarks of aging. This review will examine their nature and further expose our current understanding of the role played by these peptides in aging and their contribution to tissue homeostasis and several pathologies.
Cooperation experience in a multicentre study to define the upper limits in a normal population for the diagnostic assessment of the functional lupus anticoagulant assays
Authors: Pradella Paola , Azzarini Gabriella , Santarossa Liliana , Caberlotto Livio , Bardin Cristina , Poz Alessandra , D’Aurizio Federica , Giacomello Roberta 
Published: September 2012

AbstractBackground:Phospholipid-dependent coagulation tests for lupus anticoagulant (LA) are considered an important step for the diagnosis of anti-phospholipid syndrome; however, LA laboratory detection is difficult because of many variables. Five hospital laboratories, located in a North-Italy area and using the same method for LA testing, cooperated to standardise sample treatment and analytical procedure in order to define the upper values for LA negativity.Methods:In total, 200 normal subjects (40 for each centre) were studied for six LA functional assays, using the same procedure, reagent lot and analyser type. The first tests done were LA screen and LA confirm assays, based on diluted Russell’s Viper Venom Time, with low and high phospholipid content, respectively. The second tests performed were silica clotting time screen and confirm assays, based on activated partial thromboplastin time, with low and high phospholipid content, respectively. Finally, two mixing assays were executed for both screening assays, diluting patient sample with a pool prepared with plasma collected from the study population.Results:Data analysis demonstrated a difference between centres for all assays when results were expressed in seconds; the difference disappeared when results are normalised with the local mean normal value of each centre and are expressed as a normalised ratio. The study population was normally distributed; so the value corresponding to 99th percentile was used as limit value for LA negativity. Values expressed as normalised ratio, for LA and silica clotting time screenings were 1.22 and 1.23, respectively.Conclusions:The study allowed us to define a uniform approach to LA testing and evaluation for laboratories employing the same methods.
Faecal calprotectin: comparative study of the Quantum Blue rapid test and an established ELISA method
Authors: Coorevits Liselotte , Baert Filip J. , Vanpoucke Hilde J.M. 
Published: September 2012

Abstract

Background: Faecal calprotectin is a non-invasive marker for neutrophilic intestinal inflammation. It can be used in the differential diagnosis between functional and organic bowel disease. Moreover, it correlates with endoscopic organic bowel disease activity. The objective of this study is to evaluate a recently launched quantitative immunochromatographic point-of-care test: Quantum Blue Calprotectin (Bühlmann Laboratories AG, Schönenbuch, Switzerland) in comparison to an established ELISA method (Bühlmann Laboratories AG).

Methods: We included 142 samples, either archived (–80°C) faecal extracts or fresh routine samples. Both the normal range cartridges as well as the high range cartridge from the point-of-care test were used. The ELISA was compared with the point-of-care test and the optimal the point-of-care test cut-off values were searched for using Microsoft® Excel 2002 and MedCalc Software version 10.0.0.0 (Mariakerke, Belgium).

Results: In the method comparison a determination coefficient (R2) of 0.89 was found. The Passing Bablok regression analysis showed a significant deviation from linearity (y=–40.8+1.0x). The use of a cut-off value of 30 μg/g faeces and a grey zone of 30–110 μg/g faeces resulted in the best agreement between the ELISA interpretation and the point-of-care test interpretation, with 89.4% (127/142) agreement and 10.6% (15/142) mismatches.

Conclusions: We may conclude that the point-of-care test can serve as a reliable alternative to the time consuming ELISA in the differential diagnosis between functional and organic bowel disease. Furthermore, it seems to be reliable in the follow-up of inflammatory bowel disease patients.
In vitro effects of three antidepressant drugs on plasma paraoxonase activity
Authors: Saadaoui Mohamed Hachem , Hellara Ilhem , Neffati Fadoua , Mechri Anouar , Douki Wahiba , Gaha Lotfi , Najjar Mohamed Fadhel 
Published: September 2012

Abstract

Background: Paraoxonase 1 (PON1) is important in organophosphates and xenobiotic metabolism and as an antioxidant bio-scavenger. PON1 activity was shown to significantly decrease in depressed patients after antidepressant treatment instauration. Our aim was to investigate the in vitro inhibitory effects of three antidepressants (imipramine, amitriptyline and fluoxetine) on PON1 activity.

Methods: Plasma from healthy volunteers was spiked with antidepressant drugs. The working solutions were then diluted with plasma to obtain concentrations that covered the therapeutic margin. PON1 was tested by a kinetic method in triplicate after incubation at 37°C for 2 h.

Results: Tricyclic antidepressants significantly inhibited PON1. Fluoxetine had no effect. The inhibition percentage for imipramine was 15.6% at 100 μg/L after incubation for 1 h (131±1 vs. 155±2 IU/L; p<0.01). At 350 μg/L, the inhibition percentage for imipramine 19.2% after 1 h and 20.2% after 2 h. Amitriptyline was a stronger inhibitor: 26% after 30 min at 125 μg/L. At 250 μg/L, the inhibition percentage for amitriptyline was 36.5% after 30 min (100±4 vs. 159±2 IU/L; p<0.01).

Conclusions: The tested tricyclic antidepressants significantly inhibit PON1 activity in a concentration-dependent manner. Amitriptyline had a higher inhibition potency than imipramine.
Implementing a Classification Scheme for Enterprise 2.0
Authors: Back Andrea , Irmler Peter 
Published: September 2012

Abstract
Enterprise 2.0 is a broad term. It comprises not only the diverse applications of social software in organisations, but also the cultural and organisational change along with them. A generally accepted classification scheme that covers the diverse aspects of specific social software solutions had not yet been established. Such a classification scheme would be helpful to clarify young terms like Enterprise 2.0 or social software and to establish a common understanding. In this paper we present a classification scheme and how it was developed. Through a literature analysis of publications from academia and practice and of keywords used in online case study sites, 37 classification categories were derived. Based on a survey, 13 classification categories were chosen to be implemented in a web-based case study platform, and their value ranges were determined. Round about 100 case studies in the Enterprise 2.0 Case Study Network e20cases.org have been tagged accordingly and can be easily used for search and retrieval. In this article we describe selected categories in more detail: objectives, fields of application and success factors as well as barriers in the implementation process of Enterprise 2.0 in organizations, as they are not self-explanatory.
From Groupware to Social Media — Extending an Existing Shared Workplace System with Social Media Features
Authors: Prinz Wolfgang , Kolvenbach Sabine 
Published: September 2012

Abstract
This paper investigates major differences between organizational cooperation and social media platforms to identify ways for the evolution of a cooperation platform into a social media platform. This analysis starts with an investigation of existing social media application to identify important characteristics related to organizational cooperation. This is followed by mapping these to traditional cooperation platforms using BSCW for illustration.
Blick in die Zukunft der Fertigungsmesstechnik
Authors: Imkamp Dietrich , Schmitt Robert , Berthold Jürgen 
Published: September 2012

Zusammenfassung
“Scheller, Sicherer, Genauer und Flexibler” ist der Titel der von der VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik herausgegebenen “Roadmap Fertigungsmesstechnik”. Das Dokument liefert einen Ausblick auf die Entwicklung der Messtechnik in der industriellen Produktion in den nächsten zehn Jahren. Es wurde von einer deutschen Expertengruppe aus Forschung und Industrie erarbeitet. Dieses Manuskript fasst den Inhalt der Roadmap zusammen und erläutert die einzelnen Überschriften “Scheller, Sicherer, Genauer und Flexibler” anhand von Beispielen.
Application of Light Refractive Tomography for Reconstructing Ultrasound Fields in Various Media
Authors: Chen Lizhuo , Rupitsch Stefan J. , Lerch Reinhard 
Published: September 2012

Abstract
This paper describes an optical measurement technique, referred to as light refractive tomography (LRT), which enables noninvasive measurement of ultrasound pressure fields in water. The pressure field arising from a cylindrically focused ultrasound transducer is measured separately by means of LRT and hydrophone. Good agreement is achieved between the results obtained by these two different methods. After that, LRT is extended and applied to the reconstruction of density variations in a PMMA block induced by ultrasound. The results appear plausible, however, a quantitative verification is currently still missing, since we know of no other published methods succeeding so far in the measurement of density change in solids induced by ultrasound.
Impedance Spectra of Pt(100) in Aqueous H2SO4 and HCl Solutions Around the Hydrogen Adsorption-Desorption Peak
Authors: Pajkossy Tamás 
Published: September 2012

Abstract
Impedance spectra of Pt(100) in aqueous 0.5 M H2SO4 and 1 M HCl solutions have been measured in a potential range which includes the hydrogen adsorption/desorption peak and the double layer region. In the latter potential region the positive surface charge and the large dc capacitance imply that the double layer consist mostly of adsorbed anions; the capacitance spectra are markedly different for the two systems, revealing that adsorption/desorption is much faster for sulphate than for chloride.
Adsorption of Additives: Hardness and Softness at Electrified Interfaces
Authors: Plieth Waldfried 
Published: September 2012

Abstract
The search for effective additives is important for the development of new metal deposition processes. The hard/soft concept is a possible way for the selection of suitable substances.
Hardness or softness are connected with molecular properties like electronegativity or the chemical potential of electrons. The density functional theory (DFT) provides methods for calculating the respective values. Corresponding function of the side of the electrode is the Fermi energy, the upper level of occupied electron energy levels. Hardness and softness of the electrode depend on the electrode potential. This dependence will be discussed.
Parahydrogen Induced Polarization in Scalar Coupled Systems: Analytical Solutions for Spectral Patterns and their Field Dependence
Authors: Ivanov Konstantin L. , Yurkovskaya Alexandra V. , Vieth Hans-Martin 
Published: September 2012

Abstract
We have obtained analytical solutions for Para-Hydrogen Induced Polarization (PHIP) for several types of coupled spin systems, namely, for AB-, ABX-, AA´A´´- and A2B-systems. Scalar spin-spin interactions were considered the factor, that determines the PHIP spectral pattern; it is the variation of the spin coupling regime (from strong coupling at low field to weak coupling at high field), which is responsible for the PHIP magnetic field dependence. The field dependence of polarization was considered in detail, general peculiarities of PHIP were found, PHIP patterns were calculated for the systems mentioned. Special attention was paid to the effects of field switching on PHIP.
NMR Study of Local and Long Range Dynamics of Adsorbed Water in Zeolite NaY(Br)
Authors: Pahlke Hannes , Lusceac Sorin Adrian , Geil Burkhard , Fujara Franz 
Published: September 2012

AbstractThe dynamics of partially deuterated water in zeolite NaY(Br) are investigated by a combination of several NMR methods for two different loadings, 4 water molecules and 18 water molecules per supercage. Information on local dynamics is obtained by1H and2H NMR spin-lattice relaxation,2H NMR solid-echo spectra and2H NMR stimulated echo decay curves. The water long range diffusion has been studied by1H NMR static field gradient experiments. The most important findings are as follows: The mechanism of water dynamics depends strongly on the degree of loading. This is clearly reflected in both, local and long range motion. The intermediate2H NMR spectra might be explained referring to a model proposed by O'Hare et al.: It is based on two different populations of water molecules performing tetrahedral jumps respectively C2-flips of their OH bonds. Alternative models for the local water dynamics, distorted tetrahedral jumps and a distribution of correlation times, are also discussed.
Lifting of Thermally-Induced Surface Reconstruction on Au(100) Electrode by Protonated Molecules of Dopamine
Authors: Skoluda Piotr 
Published: September 2012

Abstract
A study of the current-potential and capacity curves of Au(100) electrode prepared by flame method provide evidence that not only anions or organic molecules but also cations (protonated molecules of dopamine) can lift the reconstruction. Our investigation indicate also that coumarin hinders the adsorption of these cations and thus delays lifting of the reconstruction. It was found that the deprotonated form of dopamine also lifts the reconstruction but at much more negative potentials.
New Environmental Friendly Process Aids Improve Bitumen Recovery and Accelerate Tailings Settling of Low Grade Oil Sands
Authors: Mahmoudkhani Amir , Fenderson Thomas , Watson Philip , Wu Yongfu , Nair Mohan 
Published: September 2012

Abstract
Current water management strategies require recycling and reuse of oil sand process affected water (OSPW) to as much as 80%. Continuous recycling and reuse of OSPW degrades water quality as the concentrations of total dissolved solids (TDS) and dissolved organic materials (DOM) accumulate. This results in a net increase in operating and maintenance costs and an impact on the extraction process and bitumen recovery. Remaining water containing fines and suspended clays adds to the mature fine tailings and associated problems for tailings pond treatment and management. Presence of residual bitumen and other organics is known to create difficulties in common practices for flocculation and dewatering of tailings. With the problems stated above, one may consider a pre-treatment approach rather than the common post-treatment remedies.
The ore grade profoundly affects the efficiency of bitumen recovery in the hot water extraction of bitumen, the principal step in the bitumen extraction process. Sodium hydroxide is commonly added to the conditioning step to improve bitumen recovery. As the sodium ions build in concentration, they disperse clays in the ore and create tailings that resist dewatering. This is especially true for low-grade and oxidized ores, which present the greatest challenges in bitumen recovery and produce the major portion of tailings due to high fines content. With current trends for increasing production from mining operations to almost double by 2020, industry has to adopt new technologies to manage tradeoffs between water and energy.
We present a new approach toward total water management by introducing environmentally friendly process aids that can improve bitumen recovery from low-grade oil sands ores. Lab-scale experimental data from a Denver flotation cell and hydrotransport loop were analyzed to evaluate the efficiency on the processability of high and low grade oil sands, water chemistry and tailings management. The results demonstrate that using new process aids during the conditioning stage improves bitumen recovery from low-grade oil sands and can accelerate tailings settling. This pretreatment approach can be incorporated into current oil sands mining processing facilities and delivers environmental and economical benefits. A critical evaluation for use of new process aids versus sodium hydroxide is given in detail.
The Transformation of an E&P Company's Approach to Asset Development
Authors: Mills Tim , Luan Pete 
Published: September 2012

Abstract
This paper tells the story of the steps that an E&P company took in implementing a methodology to plan, deliver and execute capital projects predictably. It addresses the challenges that any organization faces in effecting change, as well as the actions taken to ensure success for the initiative. This story can serve as a blueprint for any organization that wishes to improve capital performance.
The focus of the paper is not so much the solution implemented, but rather the steps the organization took to ensure a successful implementation. In this paper, the terms "project delivery system" and "asset development system" will be used interchangeably.
The company wanted to improve the predictability of its delivery of major capital projects. The company felt that to meet its business objectives, one of many things it needed to do was improve its capital execution or asset development performance.
E&P companies have many paths to growth while achieving sustainability. A traditional approach is to grow via exploration while producing efficiently. Exploration and production are recognized critical competencies for E&P firms. What is often not appreciated is that the path from exploration to production must go through asset development or capital project execution.
The figure below illustrates the three major competencies that an E&P company needs to grow. Often, firms choose the acquisition path in lieu of exploration. Nonetheless, short of acquiring fully mature assets, there is always some exploration work necessary