bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simplified method for autologous stem cell transplantation in multiple myeloma
Authors: Bekadja Mohamed-Amine , Brahimi Mohamed , Osmani Soufi , Arabi Abdessamed , Bouhass Rachid , Yafour Nabil , Entasoltan Badra , Rasheed Walid , Attaf Fadela 
Published: July 2014

BACKGROUND AND OBJECTIVES:
We evaluated the efficacy and safety of non-cryopreserved storage of autologous hematopoietic stem cells with no post-transplant granulocyte colony-stimulating factor (G-CSF) support in adult patients undergoing autologous stem cell transplantation (ASCT) for multiple myeloma (MM).

DESIGN AND SETTING:
Retrospective review of patients undergoing ASCT from May 2009 to July 2011.

PATIENTS AND METHODS:
Autologous stem cell were mobilized using G-CSF. Leukapheresis to harvest stem cells was performed on day -2 and -1. The grafts were kept in a conventional blood bank refrigerator at 4°C until reinfusion on day 0. The conditioning regimen consisted of melphalan 200 mg/m2 in all patients. The postchemotherapy myeloablative phase was managed without growth factors.

RESULTS:
Between May 2009 to July 2011, 54 adults with MM were treated in our center in oran. The median age at ASCT was 55 years (range, 35-65). There were 37 males and 17 females. the median harvested CD34+ cell count was 3.60×106/kg (range, 1.90 to 10.52). All patients had neutrophil engraftment on the median of day 10 (range, 6-17) and platelet transfusion independence on the median of day 13 (range 9-24). In the 47 evaluable patients the median post-transplant overall survival had not been reached; the estimated overall survival at 30 months was 93.8% (0.05%), and the estimated disease-free survival at 27 months was 93.6% (0.05%).

CONCLUSION:
High -dose chemotherapy and ASCT using non-cryopreserved stem cells and no G-CSF support is safe and feasible in the treatment of MM under our work conditions in developing countries.
Effect of Soaking and Cooking Methods on Extraction of Solids and Acceptability of Tiger Nut (Cyperus Esculentus L) Milk
Authors: Asante Frank A. , Ellis William O. , Oduro Ibok , Saalia Firibu K. 
Published: July 2014

Vegetable milk is a nutritious alternative for consumers who for dietary and other constraints cannot consume dairy milk. The production of vegetable milk solids of acceptable taste and quantity is however an important consideration. The study determined the effect of soaking in combination with boiling, steaming and roasting on the yield of milk, solids and its sensory quality. Boiling of tubers before soaking yielded the highest quantity of milk for all tubers with a range of 4395.5 g kg-1 to 6530.4 g kg-1. Boiling before soaking however gave the lowest milk solids for the tubers with the lowest and highest recorded as 101.0 g kg-1 and 139.0 g kg-1 respectively. Expected milk solids for all pre-treatments ranged from 541.4 g kg-1 to 619.4 g kg-1 for black tubers and 571.4 g kg-1 to 710.2 g kg-1 for the brown tubers. Roasting before soaking of brown tubers enhanced the flavor of milk however there were no differences in overall acceptability of milk extracted from different pre-treated tubers. This sequence of pretreatments will enhance the extraction of good quality tiger nut milk and solids to broaden its utilization as ingredient in the food industry.
Maximizing the benefits of antiretroviral therapy for key affected populations
Authors: Grubb Ian R , Beckham Sam W , Kazatchkine Michel , Thomas Ruth M , Albers Eliot R , Cabral Mauro , Lange Joep , Vella Stefano , Kurian Manoj , Beyrer Chris ,   for the IAS Treatment for Key Affected Populations Working Group
Published: July 2014

IntroductionScientific research has demonstrated the clinical benefits of earlier initiation of antiretroviral treatment (ART), and that ART can markedly reduce HIV transmission to sexual partners. Ensuring universal access to ART for those who need it has long been a core principle of the HIV response, and extending the benefits of ART to key populations is critical to increasing the impact of ART and the overall effectiveness of the HIV response. However, this can only be achieved through coordinated efforts to address political, social, legal and economic barriers that key populations face in accessing HIV services.DiscussionRecent analyses show that HIV prevalence levels among key populations are far higher than among the general population, and they experience a range of biological and behavioural factors, and social, legal and economic barriers that increase their vulnerability to HIV and have resulted in alarmingly low ART coverage. World Health Organization 2014 consolidated guidance on HIV among key populations offers the potential for increased access to ART by key populations, following the same principles as for the general adult population. However, it should not be assumed that key populations will achieve greater access to ART unless stigma, discrimination and punitive laws, policies and practices that limit access to ART and other HIV interventions in many countries are addressed.ConclusionsRights‐based approaches and investments in critical enablers, such as supportive legal and policy environments, are essential to enable wider access to ART and other HIV interventions for key populations. The primary objective of ART should always be to treat the person living with HIV; prevention is an important, additional benefit. ART should be provided only with informed consent. The preventive benefits of treatment must not be used as a pretext for failure to provide other necessary HIV programming for key populations, including comprehensive harm reduction and other prevention interventions tailored to meet the needs of key populations. An end to AIDS is only possible if we overcome the barriers of criminalization, stigma and discrimination that remain key drivers of the HIV epidemics among key populations.
Local time resolved dynamics of field‐aligned currents and their response to solar wind variability
Authors: He Maosheng , Vogt Joachim , Lühr Hermann , Sorbalo Eugen 
Published: July 2014

AbstractUsing 10 years of CHAMP measurements condensed into the empirical model of field‐aligned currents through empirical orthogonal function analysis, the dynamics of field‐aligned currents (FACs) is modeled and studied in separate magnetic local time (MLT) sectors. We investigate the distributions of FAC intensity and latitude and evaluate their predictability in terms of geospace parameters which are ranked according to their relative importance measured by a multivariate regression procedure. The response time to changes in solar wind variables is studied in detail and found to be much shorter for dayside FACs than on the nightside (15–25 min versus 35–95 min). Furthermore, dayside FACs can be parameterized more accurately: R2 values maximize greater than 0.7 for FAC latitude and greater than 0.3 for FAC intensity, whereas the corresponding values on the nightside are smaller than 0.3 and 0.15, respectively. The results support the separation between directly driven coupling processes acting on the dayside and unloading processes controlling the nightside. In addition, the MLT‐resolved standardized regression coefficients suggest that (1) FAC latitude is affected most significantly by the transpolar potential, substorm evolution, solar activity as represented by the F10.7 index and its square, and the dipole tilt; (2) Region‐1/2 current intensity is controlled most efficiently by substorm evolution, IMF Bz and IMF By; and (3) cusp current intensity is influenced by conductivity, IMF By and their cross item.
Recent Advances in Polymeric Solvent‐Resistant Nanofiltration Membranes
Authors: Cheng Xi Quan , Zhang Yong Ling , Wang Zhen Xing , Guo Zhan Hu , Bai Yong Ping , Shao Lu 
Published: July 2014

AbstractWhen considering energy consumption and environmental issues, solvent‐resistant nanofiltration (SRNF) based on polymeric materials emerges as a process for substituting conventional separation processes of organic solutions, such as distillation, which consume high amounts of energy. Because SRNF does not involve phase transition, this process can potentially decrease the energy consumption and solvent waste and increase the yield of active components. Such improvements could significantly benefit a number of fields, such as pharmaceutical manufacturing and catalysis recovery, among others. Therefore, SRNF has gained a lot of attention since the recent introduction of solvent‐stable polymeric materials in the manufacture of nanofiltration membranes. The membrane materials and the membrane structures depending on the fabrication methods determine the separation performance of polymeric SRNF membranes. Therefore, this article gives a comprehensive overview of the current state‐of‐art technologies of generating membrane materials and corresponding fabrication methods for SRNF membranes made from polymeric materials expected to provide the most benefit. The transport mechanisms and the corresponding models of SRNF membranes in organic media are also reviewed to better understand the mass transfer process. Various SRNF applications, such as in pharmaceutical and catalyst, among others, are also discussed. Finally, the difficulties and future research directions to overcome the challenges faced by SRNF processes are proposed.
A genome‐wide linkage scan of bipolar disorder in Latino families identifies susceptibility loci at 8q24 and 14q32
Authors: Gonzalez Suzanne , Camarillo Cynthia , Rodriguez Marco , Ramirez Mercedes , Zavala Juan , Armas Regina , Contreras Salvador A. , Contreras Javier , Dassori Albana , Almasy Laura , Flores Deborah , Jerez Alvaro , Raventós Henriette , Ontiveros Alfonso , Nicolini Humberto , Escamilla Michael 
Published: July 2014

AbstractA genome‐wide nonparametric linkage screen was performed to localize Bipolar Disorder (BP) susceptibility loci in a sample of 3757 individuals of Latino ancestry. The sample included 963 individuals with BP phenotype (704 relative pairs) from 686 families recruited from the US, Mexico, Costa Rica, and Guatemala. Non‐parametric analyses were performed over a 5 cM grid with an average genetic coverage of 0.67 cM. Multipoint analyses were conducted across the genome using non‐parametric Kong & Cox LOD scores along with Sall statistics for all relative pairs. Suggestive and significant genome‐wide thresholds were calculated based on 1000 simulations. Single‐marker association tests in the presence of linkage were performed assuming a multiplicative model with a population prevalence of 2%. We identified two genome‐wide significant susceptibly loci for BP at 8q24 and 14q32, and a third suggestive locus at 2q13‐q14. Within these three linkage regions, the top associated single marker (rs1847694, P = 2.40 × 10−5) is located 195 Kb upstream of DPP10 in Chromosome 2. DPP10 is prominently expressed in brain neuronal populations, where it has been shown to bind and regulate Kv4‐mediated A‐type potassium channels. Taken together, these results provide additional evidence that 8q24, 14q32, and 2q13‐q14 are susceptibly loci for BP and these regions may be involved in the pathogenesis of BP in the Latino population. © 2014 Wiley Periodicals, Inc.
The Effects of Age on the Morphometry of the Cervical Spinal Cord and Spinal Column in Adult Rats: An MRI‐Based Study
Authors: Laing Andrew C. , Brenneman Elora C. , Yung Andrew , liu Jie , Kozlowski Piotr , Oxland Thomas 
Published: July 2014

ABSTRACTRat models are commonly used to investigate the pathophysiological pathways and treatment outcomes after spinal cord injury (SCI). The high incidence of fall‐induced SCI in older adults has created a need for aging models of SCI in rats to investigate potential age‐related differences in SCI severity and outcomes. The aims of this study were to determine the influences of age and vertebral level on the geometries of the cervical spinal cord and spinal column in a rat model. Three young (3 months) and three aged (12 months) Fischer 344 rats were imaged in a high field (7 T) small‐animal magnetic resonance imaging system. All spinal cord geometry variables (including depth, width, and axial cross‐sectional area) and one spinal canal variable (depth) were significantly larger in the aged specimens by an average of 8.1%. There were main effects of vertebral level on all spinal cord variables and four spinal canal variables with values generally larger at C4 as compared to C6 (average increases ranged from 5.7% to 12.9% in spinal cord measures and 5.4% to 6.8% in spinal canal measures). High inter‐rater reliability between two measurers was observed with a mean intraclass correlation of 0.921 and percent difference of 0.9% across all variables measured. This study clearly demonstrates that cervical spinal cord geometry changes between the ages of 3 and 12 months in Fischer 344 rats. This information can aid in the planning and interpretation of studies that use a rat model to investigate the influence of age on cervical SCI. Anat Rec, 297:1885–1895, 2014. © 2014 Wiley Periodicals, Inc.
Effect of thermal annealing on the structural and optical properties of tris‐(8‐hydroxyquinoline)aluminum(III) (Alq3) films
Authors: Cuba M. , Muralidharan G. 
Published: July 2014

AbstractTris‐(8‐hydroxyquionoline)aluminum (Alq3) was synthesized and coated on to a glass substrate using the dip coating method. The structural and optical properties of the Alq3 film after thermal annealing from 50°C to 300°C in 50° steps was studied. The films have been prepared with 2 to 16 layers (42–324 nm). The thickness and thermal annealing of Alq3 films were optimized for maximum luminescence yield. The Fourier transform infrared spectrum confirms the formation of quinoline with absorption in the region 700 − 500/cm. Partial sublimation and decomposition of quinoline ion was observed with the Alq3 films annealed at 300°C. The X‐ray diffraction pattern of the Alq3 film annealed at 50°C to 150°C reveals the amorphous nature of the films. The Alq3 film annealed above 150°C were crystalline nature. Film annealed at 150°C exhibits a photoluminescence intensity maximum at 512 nm when excited at 390 nm. The Alq3 thin film deposited with 10 layers (220 nm) at 150°C exhibited maximum luminescence yield. Copyright © 2014 John Wiley & Sons, Ltd.
Impact of adverse events, treatment modifications, and dose intensity on survival among patients with advanced renal cell carcinoma treated with first‐line sunitinib: a medical chart review across ten centers in five European countries
Authors: Porta Camillo , Levy Antonin , Hawkins Robert , Castellano Daniel , Bellmunt Joaquim , Nathan Paul , McDermott Ray , Wagstaff John , Donnellan Paul , McCaffrey John , Vekeman Francis , Neary Maureen P. , Diaz Jose , Mehmud Faisal , Duh Mei Sheng 
Published: July 2014

AbstractAngiogenesis inhibitors have become standard of care for advanced and/or metastatic renal cell carcinoma (RCC), but data on the impact of adverse events (AEs) and treatment modifications associated with these agents are limited. Medical records were abstracted at 10 tertiary oncology centers in Europe for 291 patients ≥18 years old treated with sunitinib as first‐line treatment for advanced RCC (no prior systemic treatment for advanced disease). Logistic regression models were estimated to compare dose intensity among patients who did and did not experience AEs during the landmark periods (18, 24, and 30 weeks). Cox proportional hazard models were used to explore the possible relationship of low‐dose intensity (defined using thresholds of 0.7, 0.8, and 0.9) and treatment modifications during the landmark periods to survival. 64.4% to 67.9% of patients treated with sunitinib reported at least one AE of any grade, and approximately 10% of patients experienced at least one severe (grade 3 or 4) AE. Patients reporting severe AEs were statistically significantly more likely to have dose intensities below either 0.8 or 0.9. Dose intensity below 0.7 and dose discontinuation during all landmark periods were statistically significantly associated with shorter survival time. This study of advanced RCC patients treated with sunitinib in Europe found a significant relationship between AEs and dose intensity. It also found correlations between dose intensity and shorter survival, and between dose discontinuation and shorter survival. These results confirm the importance of tolerable treatment and maintaining dose intensity.
Key Success Factors in Continuing Education
Authors: Meschke Stephan 
Published: July 2014

AbstractEin neues Programm des Bundesministeriums für Bildung und Forschung soll die Innovationsfähigkeit der neuen Bundesländer stärken. Dazu gehört Kompetenzbündelung sowie die Möglichkeit, erhaltene Forschungsergebnisse in der Wirtschaft anzuwenden. Gerade dieser Wissenstransfer aus Forschungsprojekten gestaltet sich jedoch schwierig. Daher wird im Deutschen EnergieRohstoff‐Zentrum unter der dem Titel Professional School speziell an Möglichkeiten der Hochschulweiterbildung geforscht. Dieser Beitrag stellt die damit verbundenen Ziele sowie als Ergebnis der Forschung ausgewählte Erfolgsfaktoren näher dar.
Bayesian sensitivity analyses for hidden sub‐populations in weighted sampling
Authors: Xia Michelle , Gustafson Paul 
Published: July 2014

AbstractIn this paper, we propose several Bayesian model‐based approaches for sensitivity analyses on assessments of population averages and measures of association under complex models. In particular, the proposed methods adjust for a potential impact from a hidden sub‐population when weighted sampling from the non‐hidden sub‐population is possible. Bayesian models are presented for estimating population medical expenditure and health care utilization, as well as measures of association with a binary covariate. Large‐sample limiting versions of the posteriors are obtained for all the models. Using Medical Expenditure Panel Survey data, in which individuals with higher expenditures and more frequent health care visits are more likely to be included, we illustrate how the assumption about the hidden proportion of never‐respondents may impact the final estimates of expenditure, utilization, and measures of association with a binary covariate. The Canadian Journal of Statistics 42: 436–450; 2014 © 2014 Statistical Society of Canada
New Thermodynamics for Evaluating the Surface‐phase Enrichment in the Lower Surface Tension Component
Authors: Santos M. Soledade C. S. , Reis João Carlos R. 
Published: July 2014

AbstractRegarding the surface phase of liquid mixtures as a thermodynamic phase, ideal surface phases are designed so that at fixed bulk‐phase composition, real and ideal surface phases have the same chemical composition and identical limiting slopes for the dependence of surface tension on mole fraction. Standard chemical potentials are introduced for surface phase components, and quasi‐exact expressions are worked out to compute ideal surface tensions and surface‐phase compositions of real liquid mixtures. Guidelines for choosing molecular models to estimate the molar surface area of pure constituents are given. Ideal and excess surface tensions are calculated by using literature data for aqueous ethanol solutions at 298 K. These results show treatment based on Butler’s equations grossly overestimate predicted surface tensions, thus leading to lower ethanol content in the surface phase. These inaccuracies are ascribed to the use of molar surface areas in model equations that are too small.
Synthesis, Properties, and Applications of Light‐Insensitive Silver(I) Cyanoximates
Authors: Gerasimchuk Nikolay 
Published: July 2014

AbstractThe reaction between AgNO3 and ML [M = K+, Na+; L = anion of the deprotonated cyanoxime – 39 of these anions are known, but only twelve form light‐stable silver(I) complexes] at room temperature in aqueous solutions leads to sparingly soluble, colored AgL in high yield. All twelve of the known Ag complexes were characterized by using a variety of spectroscopic methods and single‐crystal X‐ray analysis, which revealed the formation of coordination polymers of various complexities. The silver(I) compounds demonstrate a very significant (for multiple years!) stability towards visible light. There are three areas of potential practical applications of these unusual complexes: (1) detectors of UV radiation that do not require electric feed, (2) non‐electrical indicators for gases of industrial importance, (3) antimicrobial additives to light‐curable acrylate polymeric glues, fillers, and adhesives used during the introduction of indwelling medical devices. The chemical, structural, technological, and biological aspects of the application of coordination polymers based on AgI cyanoximates are reviewed.
Phosphorescent PtII Systems Featuring Both 2,2′‐Dipyridylamine and 1,3,5‐Triazapentadiene Ligands
Authors: Eliseev Ivan I. , Gushchin Pavel V. , Chen Yi‐An , Chou Pi‐Tai , Haukka Matti , Starova Galina L. , Kukushkin Vadim Yu. 
Published: July 2014

AbstractThe treatment of cis‐[Pt(dpa)(RCN)2][SO3CF3]2 {dpa = 2,2′‐dipyridylamine, R = Me, Et, CH2Ph, Ph; [2a–d](OTf)2} (OTf = SO3CF3) with 2 equiv. of N,N′‐diphenylguanidine [NH=C(NHPh)2] in CH2Cl2 solutions at room temp. for 16 h gives [Pt(dpa){NH=C(R)NC(NHPh)=NPh}][SO3CF3] {[3a,b,d](OTf)} as the addition products and [Pt(dpa){NH=C(R)NHC(R)=NH}][SO3CF3]2 {[4a,b](OTf)2} as the tailoring products. The formulation of complexes [3a,b,d](OTf) and [4a,b](OTf)2 was supported by satisfactory C, H, and N elemental analyses and agreeable high‐resolution ESI‐MS, IR, and 1H (including 1H–1H COSY experiments) and 13C{1H} NMR data. The structures of all of the platinum species were determined by single‐crystal X‐ray diffraction. The resultant complexes are nonemissive in solution, mainly because of the interaction between the empty d orbital in a square‐planar configuration and solvent molecules. However, in the solid state, complexes [3a,b,d](OTf) exhibit strong phosphorescence with quantum yields (peak wavelength) of 0.23 (490 nm), 0.27 (483 nm), and 0.20 (532 nm), respectively.
Synthesis of KF/CaO as a catalyst for the production of bio‐fuel from cracking of Cornus wisoniana oil
Authors: Lin Lin , Cui Haiying , Vittayapadung Saritporn , Xiao Zhihong , Zhang Aihua , Liu Rukuan , Li Changzhu 
Published: July 2014

This study aimed to prepare KF/CaO catalyst with high catalytic activity that can be applied to produce bio‐fuel from Cornus wisoniana oil. The KF/CaO catalyst was characterized by Brunauer–Emmett–Teller surface area (BET), XRD, scanning electron microscopy (SEM), and temperature programmed desorption (TPD). The chemical compositions of C. wisoniana oil and bio‐fuel oil were analyzed by GC–MS. The effect of the catalyst preparation conditions on catalytic activity was investigated. The optimal process conditions for the KF/CaO preparation were KF loading rate of 40%, calcination temperature of 600°C, and 4 h calcination time. Under the optimum process conditions, the bio‐fuel yield reached 82.7 and 65% bio‐fuel yield was obtained after being reused nine times. The bio‐fuel oil obtained by catalytic cracking has similar chemical compositions to petroleum‐based diesel, which exhibited good fuel properties.KF/CaO was used as a catalyst for the production of bio‐fuel from cracking of Cornus wisoniana oil.