bluuebunny/crossref_metadata_2025_split huggingface dataset:
TREATMENT OF DISTAL RADIAL FRACTURES WITH THE DVR-A PLATE — THE EARLY BRISTOL EXPERIENCE
Authors: Loveridge J. , Ahearn N. , Gee C. , Pearson D. , Sivaloganathan S. , Bhatia R. 
Published: July 2013

Aim: The aim of the study was to assess how adequately distal radial fracture reduction was reproduced and maintained with the distal volar radius anatomic DVR-A (Biomet, Inc) locking plate. Methods: We looked at a consecutive series of 111 patients treated with the DVR-A plate at our institution from 2007–2010. The preoperative, intra-operative, and postoperative films were reviewed. The AO and Frykman classification was recorded. The sagittal tilt, radial inclination, and radial length were measured on intra-operative X-rays and compared with final follow-up X-rays. The last recorded range of motion at follow-up and a functional assessment using the Disabilities of the Arm, Shoulder, and Hand (DASH) score was recorded. Results: At final follow-up a mean radial inclination of 22.22 degrees (11 to 38 degrees), radial height of 11.85 mm (6 to 18 mm), and sagittal tilt of 6.71 degrees volar (-9 to 19 degrees) was achieved. From initial post-operative films, to final follow-up X-rays there was a mean increase of 0.17 degrees in radial inclination, a mean loss of 0.36 mm radial height, and a mean loss of 2.17 degrees volar tilt. The mean extension was 46.8 degrees, flexion 48.3 degrees, pronation 77.4 degrees, supination 74.8 degrees, radial deviation 15.3 degrees and the ulnar deviation 19 degrees. The mean DASH score was 12.8 (0–68). Conclusion: The DVR-A plate achieved a highly satisfactory reduction of radial length and radial inclination, with a small loss of volar sagittal tilt at final follow-up. A good functional outcome was reported, with a satisfactory range of motion achieved. The DVR-A plate is a safe and effective treatment for unstable and intra-articular displaced distal radius fractures, particularly in younger patients, in the short term.
A MODIFIED TENSION BAND WIRING TECHNIQUE FOR TREATMENT OF THE BONY MALLET FINGER
Authors: Kakinoki Ryosuke , Ohta Soichi , Noguchi Takashi , Kaizawa Yukitoshi , Itoh Hiromu , Duncan Scott F. , Matsuda Shuichi 
Published: July 2013

Purpose: To report the outcomes of mallet fractures treated with our modified tension band wiring technique.Methods: Eleven men and two women (mean age; 33 years) with mallet fractures in which happened more than five weeks before surgery, or with fracture fragments involving more than 2/3 or less than 1/3 of the distal phalanx articular surface or with previous surgical intervention, were subjected to this study. The fracture fragment was fixed with a modified tension band wiring technique using a stainless steel wire and an injection needle.Results: All patients achieved bone union in nine weeks in average. All patients had no pain except one with mild pain. No patient showed a gap or step-off greater than 1 mm.Conclusions: Our tension band wiring technique can be used regardless of the size of the dorsal fracture fragment or the interval between injury and surgery.
Fault and fracture distribution within a tight-gas sandstone reservoir: Mesaverde Group, Mamm Creek Field, Piceance Basin, Colorado, USA
Authors: Baytok Sait , Pranter Matthew J. 
Published: July 2013

The distribution and orientation of faults, fracture intensity and seismic-reflection characteristics of the Mesaverde Group (Williams Fork and Iles formations) at Mamm Creek Field vary stratigraphically, and with lithology and depositional setting. For the Mesaverde Group, the occurrence of faults and natural fractures is important as they provide conduits for gas migration, and enhance the permeability and productivity of the tight-gas sandstones. The Upper Cretaceous Mesaverde Group represents fluvial, alluvial-plain, coastal-plain and shallow-marine depositional environments.
Structural interpretations based on three-dimensional (3D) seismic-amplitude data, ant-track (algorithm that enhances seismic discontinuities) seismic attributes and curvature attributes are utilized jointly to understand the complex fault characteristics of the Williams Fork Formation. This study reveals that the lowermost lower Williams Fork Formation is characterized by NNW- and east–west-trending small-scale thrust and normal faults. Study suggests that the uppermost lower Williams Fork Formation, and the middle and upper Williams Fork formations, exhibit NNE- and east–west-trending arrays of fault splays that terminate upwards and do not appear to displace the upper Williams Fork Formation. In the uppermost Williams Fork Formation and Ohio Creek Member, NNE-trending discontinuities are displaced by east–west-trending events and the east–west-trending events dominate.

Fracture analysis, based on borehole-image logs, together with ant-track and attenuation-related seismic attributes, illustrates the spatial variability of fracture intensity and lithological controls on fracture distribution. In general, higher fracture intensity occurs within the southern, southwestern and western portions of the field, and fracture intensity is greater within the fluvial sandstone deposits of the middle and upper Williams Fork formations. More than 90% of natural fractures occur in sandstones and siltstones.
In situ
stress analysis, based on induced-tensile fractures and borehole breakouts, indicates a NNW orientation of present-day maximum horizontal stress (

S

H

max

), an approximate 20° rotation (in a clockwise direction) in the orientation of

S

H

max

with depth and an abrupt stress shift below the Williams Fork Formation within the Rollins Sandstone Member.
The Mamluk Sultanate as a Military Patronage State: Household Politics and the Case of the Qalāwūnid bayt (1279-1382)
Authors: Van Steenbergen Jo 
Published: June 2013

Abstract
This article focuses on the conceptualisation of Mamluk socio-political organisation in late thirteenth and early to mid-fourteenth-century Egypt and Syria. Breaking free of the heuristic constraints imposed on Mamluk studies by the paradigm of the political elite as defined by the normative exclusivism of elite military slavery—the so-called Mamluk system—it demonstrates that apparent dynastic attitudes were no mere façade for that system but rather powerful representations of the Mamluk version of a long-standing regional tradition of socio-political organisation: the military patronage state. It is argued here that this tradition, with its focus on military leadership, patronage ties, household bonds, and unstable devolved authorities, coalesced between 1279 and 1382 in Qalāwūnid leadership over and monopolisation of Syro-Egyptian societies.
A Partnership Gone Bad: Business Relationships and the Evolving Law of the Cairo Geniza Period
Authors: Cohen Mark R. 
Published: June 2013

Abstract
Economic historians, beginning with Avner Greif, have looked to business letters from the Cairo Geniza to understand how medieval merchants in the Islamic Mediterranean organized business collaboration. They have noticed the prevalence of agency relations, which followed “informal” arrangements, unlike formal partnerships, which employed written contracts. This “method” was called ṣuḥba (“companionship”) in Arabic, and it entailed reciprocal exchange of favors between business “friends.” Much attention has been given to what Greif calls “private order” enforcement of agency contracts, whereby merchants belonging to a “closed” consortium reported instances of cheating or opportunism by a fellow merchant, in place of enforcement by religious courts. However, economic historians relying on the Geniza documents have paid inadequate attention to evolving Jewish law in the Islamic milieu. The present article, focusing on a mercantile dispute, brings evidence to show that Jewish legal scholars adopted a feature of Islamic judicial practice to strengthen their role in enforcement of informal agency contracts. In his Code, the Mishneh Torah, Maimonides put the final touches on this accommodation by incorporating agency into the law pertaining to contract enforcement among partners.
Silver Flow and Horse Supply to Sultanate Bengal with Special Reference to Trans-Himalayan Trade (13th-16th Centuries)
Authors: Hussain Syed Ejaz 
Published: June 2013

Abstract
The establishment of the Sultanate rule in Bengal marked the beginning of a standard monetized economy as well as emergence of new urban centres. These two most decisive factors transformed not only the economic life of the region but brought about a new era of political economy. Sustained minting of high-quality silver coinage and regular supply of war-horses for maintaining a strong cavalry formed two fundamental tasks for the Sultanate regime particularly in view of the fact that both the items i.e. raw silver and horses were not indigenous and the rulers were wholly depended on import. The primary goal of the paper is to reflect on the silver inflow and outflow into and from Bengal region through 13th to 16th centuries and correlate this with the expenditure faced by the Bengal Sultans on the maintenance of cavalry. *
Coping Strategy and Caregiver Burden Among Caregivers of Patients With Dementia
Authors: Huang Mei-Feng , Huang Wen-Hui , Su Yi-Ching , Hou Shu-Ying , Chen Hui-Mei , Yeh Yi-Chun , Chen Cheng-Sheng 
Published: June 2013

Background: This study aims to examine whether coping strategies employed by caregivers are related to distinct symptoms of patients with dementia and to investigate the associations between burden and coping among caregivers of patients with dementia. Methods: A cross-sectional study design was used. A total of 57 caregivers of patients with dementia were enrolled. Coping strategies were assessed using the Ways of Coping Checklist, and burden was assessed using the Chinese version of Caregiver Burden Inventory. Correlations between coping and patients’ behavior or memory problems were examined. Severities of behavior and memory problems were adjusted to examine the correlations between caregiver burden and coping strategies. Results: The patients’ disruptive behavior problems were associated with avoidance, and depression problems were associated with avoidance and wishful thinking. After adjusting for severity of behavior problems, coping strategies using avoidance were positively correlated with caregiver burden. Conclusions: Emotion-focused coping strategies are a marker of caregiver burden.
Suicidal Behavior in Dementia
Authors: Sabodash Valeriy , Mendez Mario F. , Fong Sylvia , Hsiao Julia J. 
Published: July 2013

Background: Some studies report a low suicide risk in general dementia and in Alzheimer’s disease (AD). Objective: To evaluate suicidal behavior among patients with semantic dementia (SD), a disorder that impairs semantic knowledge. Methods: We reviewed the presence of active suicidal behavior and related factors among 25 patients with SD compared to 111 age-matched patients with early-onset AD. Results: In all, 5 (20%) patients with SD had suicidal behavior (2 successfully killed themselves) compared to 1 (0.9%) with AD ( P < .001). There was significantly more depression and greater premorbid history of suicidal behavior among the patients with SD compared to those with AD. Among the patients with SD, those with suicidal behavior, compared to those without, had more depression and greater insight into their deficits. Conclusions: Patients with SD are at special risk of committing suicide, particularly if they have depression and preserved insight. Possible mechanisms include an impaired sense of semantic competence with increased impulsivity.
Discriminative Analysis of Mild Alzheimer’s Disease and Normal Aging Using Volume of Hippocampal Subfields and Hippocampal Mean Diffusivity
Authors: Li Ya-Di , Dong Hai-Bo , Xie Guo-Ming , Zhang Ling-jun 
Published: June 2013

Background: Studies discovered that the hippocampal subfields are differentially affected by pathological damage, and magnetic resonance (MR) diffusion tensor imaging parameters might be more sensitive measures of early degeneration in Alzheimer’s disease (AD) than conventional MR imaging techniques. The purpose of this study was to evaluate the significance of the volume of hippocampal subfields and the mean diffusivity (MD) value of hippocampus in discrimination between mild AD and normal aging. Methods: A total of 29 patients with mild AD and 30 normal aging were scanned. Binary logistic regression analysis was applied to assess the diagnostic significance of the volumes of hippocampal subfields and the MD value of hippocampus. Results: All hippocampal subfields except right tail atrophied significantly in the mild AD group ( P < .05). The relative volumes of right CA1 and subiculum subfields entered the binary logistic regression model. The accuracy was 91.8%, which was improved to 93.9% as the MD value of right hippocampus entered the model. Conclusion: Atrophy was present in almost all hippocampal subfields at mild AD stage. The volumes of CA1 and subiculum were of the most diagnostic significance in discrimination of mild AD, which can be improved by the combination of volume and diffusivity analysis.
Coracohumeral Distances and Correlation to Arm Rotation
Authors: Brunkhorst John P. , Giphart J. Erik , LaPrade Robert F. , Millett Peter J. 
Published: July 2013

Background: Reduced coracohumeral distances have been reported to be associated with anterior shoulder disorders such as subscapularis tears, biceps tendon injuries, and leading edge supraspinatus tears. Purpose: To determine the variability in coracohumeral distance as a function of arm rotation in healthy male subjects. The null hypothesis was that no differences in coracohumeral distance would exist with respect to arm rotation. Study Design: Descriptive laboratory study. Methods: A total of 9 male participants who had full range of motion, strength, and no prior surgery or symptoms in their tested shoulders were enrolled in this institutional review board–approved study. Computed tomography scans of the shoulder were obtained for each subject. A dynamic biplane fluoroscopy system recorded internal and external shoulder rotation with the arm held in the neutral position. Three-dimensional reconstructions of each motion were generated, and the coracohumeral distance and coracoid index (lateral extension of the coracoid) were measured. Results: The mean coracohumeral distance in neutral rotation was 12.7 ± 2.1 mm. A significantly shorter minimum coracohumeral distance of 10.6 ± 1.8 mm was achieved ( P = .001) at a mean glenohumeral joint internal rotation angle of 36.6° ± 19.2°. This corresponded to a reduction in coracohumeral distance of 16.4% (range, 6.6%-29.8%). The mean coracoid index was 14.2 ± 6.8 mm. A moderate correlation ( R = −0.75) existed between the coracohumeral distance and coracoid index. Conclusion: Coracohumeral distance was reduced during internal rotation. Decreased coracohumeral distance was correlated with larger coracoid indices. Clinical Relevance: This study provides a reference value for coracohumeral distance in the healthy male population. Knowledge of how coracohumeral distance varies over the range of arm internal-external rotation may improve the clinical diagnosis and treatment plan for patients with anterior shoulder pathology, specifically subcoracoid impingement. Imaging of the coracohumeral distance during internal rotation with the hand at approximately midline should be considered to assess patients with anterior shoulder pain.
Some criteria for boundedness and compactness of the Hardy operator with some special kernels
Authors: Kufner Alois , Kuliev Komil , Oinarov Ryskul 
Published: July 2013

Abstract
We present necessary and sufficient conditions for boundedness and compactness of Hardy operator (1.4) with kernel (1.3) for

1
<
p
≤
q
<
∞

.

MSC:26D10, 26D15, 47B07, 47B34, 47B38.
Transgenically mediated shRNAs targeting conserved regions of foot-and-mouth disease virus provide heritable resistance in porcine cell lines and suckling mice
Authors: Jiao Ye , Gong Xiuli , Du Junzheng , Liu Mingqiu , Guo Xinbing , Chen Linlin , Miao Weinan , Jin Tao , Chang Huiyun , Zeng Yitao , Zheng Zhaoxin 
Published: July 2013

Abstract
Foot-and-mouth disease virus (FMDV) is responsible for substantial economic losses in livestock breeding each year, and the development of new strategies is needed to overcome the limitations of existing vaccines and antiviral drugs. In this study, we evaluated the antiviral potential of transgenic porcine cells and suckling mice that simultaneously expressed two short-hairpin RNAs (shRNAs) targeting the conserved regions of the viral polymerase protein 3D and the non-structural protein 2B. First, two recombinant shRNA-expressing plasmids, PB-EN3D2B and PB-N3D2B, were constructed and the efficiency of the constructs for suppressing an artificial target was demonstrated in BHK-21 cells. We then integrated PB-EN3D2B into the genome of the porcine cell line IBRS-2 using the piggyBac transposon system, and stable monoclonal transgenic cell lines (MTCL) were selected. Of the 6 MTCL that were used in the antiviral assay, 3 exhibited significant resistance with suppressing ratios of more than 94% at 48 hours post-challenge (hpc) to both serotype O and serotype Asia 1 FMDV. MTCL IB-3D2B-6 displayed the strongest antiviral activity, which resulted in 100% inhibition of FMDV replication until 72 hpc. Moreover, the shRNA-expressing fragment of PB-N3D2B was integrated into the mouse genome by DNA microinjection to produce transgenic mice. When challenged with serotype O FMDV, the offspring of the transgenic mouse lines N3D2B-18 and N3D2B-81 exhibited higher survival rates of 19% to 27% relative to their non-transgenic littermates. The results suggest that these heritable shRNAs were able to suppress FMDV replication in the transgenic cell lines and suckling mice.
NF-κB activation in myeloid cells mediates ventilator-induced lung injury
Authors: Ko Yi-An , Yang Ming-Chieh , Huang Hung-Tu , Hsu Ching-Mei , Chen Lee-Wei 
Published: July 2013

Abstract

Background
Although use of the mechanical ventilator is a life-saving intervention, excessive tidal volumes will activate NF-κB in the lung with subsequent induction of lung edema formation, neutrophil infiltration and proinflammatory cytokine/chemokine release. The roles of NF-κB and IL-6 in ventilator-induced lung injury (VILI) remain widely debated.

Methods
To study the molecular mechanisms of the pathogenesis of VILI, mice with a deletion of IкB kinase in the myeloid cells (IKKβ△mye), IL-6-/- to WT chimeric mice, and C57BL/6 mice (WT) were placed on a ventilator for 6 hr.
WT mice were also given an IL-6-blocking antibody to examine the role of IL-6 in VILI.

Results
Our results revealed that high tidal volume ventilation induced pulmonary capillary permeability, neutrophil sequestration, macrophage drifting as well as increased protein in bronchoalveolar lavage fluid (BALF). IL-6 production and IL-1β, CXCR2, and MIP2 expression were also increased in WT lungs but not in those pretreated with IL-6-blocking antibodies. Further, ventilator-induced protein concentrations and total cells in BALF, as well as lung permeability, were all significantly decreased in IKKβ△mye mice as well as in IL6-/- to WT chimeric mice.

Conclusion
Given that IKKβ△mye mice demonstrated a significant decrease in ventilator-induced IL-6 production, we conclude that NF-κB–IL-6 signaling pathways induce inflammation, contributing to VILI, and IкB kinase in the myeloid cells mediates ventilator-induced IL-6 production, inflammation, and lung injury.
Clinical, radiographic characteristics and immunomodulating changes in neuromyelitis optica with extensive brain lesions
Authors: Cheng Chen , Jiang Ying , Chen Xiaohong , Dai Yongqiang , Kang Zhuang , Lu Zhengqi , Peng Fuhua , Hu Xueqiang 
Published: July 2013

Abstract

Background
Neuromyelitis optica (NMO) shows various brain magnetic resonance imaging (MRI) abnormalities with recurrent central nervous system (CNS) attacks, although predominantly affecting the spinal cord and optic nerve. However, NMO with extensive involvement of the brain has infrequently been studied. We investigated the clinical, radiographic features and immunomodulating changes of NMO patients with extensive brain lesions (EBLs) in China.

Methods
NMO patients (including 16 NMO patients with EBLs and 53 NMO patients without EBLs) hospitalized during January 2006 and February 2010 were recruited and analyzed retrospectively. Data of clinical characteristics, magnetic resonance imaging (MRI) features, laboratory abnormalities, treatment details and outcomes were analyzed. All the patients received the follow-up visits for two years.

Results
EBLs in NMO were classified into four categories according to their respective MRI characteristics: 1) Tumefactive-like lesions (n=4, 25%); 2) Acute disseminated encephalomyelitis (ADEM)-like lesions (n=6, 37.5%); 3) Multiple sclerosis (MS)-like lesions (n=5, 31.25%); 4) Posterior reversible encephalopathy syndrome (PRES)-like lesions (n=1, 6.25%). NMO patients with EBLs had higher rates of encephalopathy symptoms (37.5% vs. 5.6%, p = 0.004), homonymous hemianopia (18.8% vs. 0%, p = 0.011) and AQP4 seropositivity (100% vs. 69.8%, p = 0.008) than NMO patients without EBLs (NEBLs). Immunomodulating changes (including the levels of C3, C4, ESR and CRP) were significantly higher in patients with EBLs than those without EBLs. The relapse times in EBLs during the follow-up period were more frequent than those happened in NEBLs (1.88 ± 0.30 vs. 1.23 ± 0.14, p = 0.04). The EDSS scores in EBLs patients were also much higher than those in NEBLs throughout all the whole visits of follow-up.

Conclusions
The presence of EBLs in NMO may indicate a higher diseases activity and portend a worse prognosis. CRP is a useful marker in monitoring diseases activity. Systemic inflammation may be crucial to the formation of EBLs in NMO.
Combinatorial targeting of 2 different steps in adenoviral DNA replication by herpes simplex virus thymidine kinase and artificial microRNA expression for the inhibition of virus multiplication in the presence of ganciclovir
Authors: Ibrišimović Mirza , Lion Thomas , Klein Reinhard 
Published: July 2013

Abstract

Background
Human adenoviruses are a frequent threat to immunocompromised patients, and disseminated disease is associated with severe morbidity and mortality. Current drugs are not capable of preventing all fatalities, thus indicating the need for alternative treatment strategies. Adenoviruses can be rendered susceptible to antiherpetic prodrugs such as ganciclovir (GCV), upon expression of the herpes simplex virus thymidine kinase (HSV-TK) gene in adenovirus-infected cells. Furthermore, adenoviruses are amenable to post-transcriptional gene silencing via small interfering RNAs (siRNAs) or artificial micro RNAs (amiRNAs).

Results
In this study, we combined these 2 approaches by constructing a combinatorial gene expression cassette that comprises the HSV-TK gene and multiple copies of an amiRNA directed against the mRNA encoding the adenoviral preterminal protein (pTP). HSV-TK gene expression was controlled by the adenoviral E4 promoter, which is activated in the presence of the adenoviral E1 gene products (i.e., when adenovirus is present in the cell). When inserted into a replication-deficient (E1-, E3-deleted) adenoviral vector, this cassette effectively inhibited the replication of wild-type adenovirus in vitro. The reduction rate mediated by the combinatorial approach was higher compared to that achieved by either of the 2 approaches alone, and these obvious additive effects became most pronounced when the GCV concentration was low.

Conclusions
The concept presented here has the potential to aid in the inhibition of wild-type adenovirus replication. Furthermore, the combinatorial expression cassette may constitute a safeguard to potentially control unintended replication of adenoviral vectors and to prevent immune responses provoked by them.