bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis
Authors: Meednu Nida , Zhang Hengwei , Owen Teresa , Sun Wen , Wang Victor , Cistrone Christopher , Rangel‐Moreno Javier , Xing Lianping , Anolik Jennifer H. 
Published: November 2015

ObjectiveRheumatoid arthritis (RA) is a systemic autoimmune disease that often leads to joint damage. The mechanisms of bone damage in RA are complex, involving activation of bone‐resorbing osteoclasts (OCs) by synoviocytes and Th17 cells. This study was undertaken to investigate whether B cells play a direct role in osteoclastogenesis through the production of RANKL, the essential cytokine for OC development.MethodsRANKL production by total B cells or sorted B cell subpopulations in the peripheral blood and synovial tissue from healthy donors or anti–cyclic citrullinated peptide–positive patients with RA was examined by flow cytometry, real‐time polymerase chain reaction, enzyme‐linked immunosorbent assay, and immunohistochemical analysis. To define direct effects on osteoclastogenesis, B cells were cocultured with CD14+ monocytes, and OCs were enumerated by tartrate‐resistant acid phosphatase staining.ResultsHealthy donor peripheral blood B cells were capable of expressing RANKL upon stimulation, with switched memory B cells (CD27+IgD−) having the highest propensity for RANKL production. Notably, switched memory B cells in the peripheral blood from RA patients expressed significantly more RANKL compared to healthy controls. In RA synovial fluid and tissue, memory B cells were enriched and spontaneously expressed RANKL, with some of these cells visualized adjacent to RANK+ OC precursors. Critically, B cells supported OC differentiation in vitro in a RANKL‐dependent manner, and the number of OCs was higher in cultures with RA B cells than in those derived from healthy controls.ConclusionThese findings reveal the critical importance of B cells in bone homeostasis and their likely contribution to joint destruction in RA.
Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology
Authors: Kharlamova Nastya , Jiang Xia , Sherina Natalia , Potempa Barbara , Israelsson Lena , Quirke Anne‐Marie , Eriksson Kaja , Yucel‐Lindberg Tülay , Venables Patrick J. , Potempa Jan , Alfredsson Lars , Lundberg Karin 
Published: November 2015

ObjectiveTo investigate the role of the periodontal pathogen Porphyromonas gingivalis in the etiology of rheumatoid arthritis (RA) by analyzing the antibody response to the P gingivalis virulence factor arginine gingipain type B (RgpB) in relation to anti–citrullinated protein antibodies (ACPAs), smoking, and HLA–DRB1 shared epitope (SE) alleles in patients with periodontitis, patients with RA, and controls.MethodsAnti‐RgpB IgG was measured by enzyme‐linked immunosorbent assay in 65 periodontitis patients and 59 controls without periodontitis, and in 1,974 RA patients and 377 controls without RA from the Swedish population‐based case–control Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study. Autoantibody status, smoking habits, and genetic data were retrieved from the EIRA database. Differences in antibody levels were examined using the Mann‐Whitney U test. Unconditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (95% CIs) for the association of anti‐RgpB IgG with different subsets of RA patients.ResultsAnti‐RgpB antibody levels were significantly elevated in periodontitis patients compared to controls without periodontitis, in RA patients compared to controls without RA, and in ACPA‐positive RA patients compared to ACPA‐negative RA patients. There was a significant association between anti‐RgpB IgG and RA (OR 2.96 [95% CI 2.00, 4.37]), which was even stronger than the association between smoking and RA (OR 1.37 [95% CI 1.07, 1.74]), and in ACPA‐positive RA there were interactions between anti‐RgpB antibodies and both smoking and the HLA–DRB1 SE.ConclusionOur study suggests that the previously reported link between periodontitis and RA could be accounted for by P gingivalis infection, and we conclude that P gingivalis is a credible candidate for triggering and/or driving autoimmunity and autoimmune disease in a subset of RA patients.
Solving Fixed Final Time Fractional Optimal Control Problems Using the Parametric Optimization Method
Authors: Idiri Ghania , Djennoune Saïd , Bettayeb Maamar 
Published: November 2015

AbstractIn this paper, the parametric optimization method is used to find optimal control laws for fractional systems. The proposed approach is based on the use for the fractional variational iteration method to convert the original optimal control problem into a nonlinear optimization one. The control variable is parameterized by unknown parameters to be determined, then its expression is substituted into the system state‐space model. The resulting fractional ordinary differential equations are solved by the fractional variational iteration method, which provides an approximate analytical expression of the closed‐form solution of the state equations. This solution is a function of time and the unknown parameters of the control law. By substituting this solution into the performance index, the original fractional optimal control problem reduces to a nonlinear optimization problem where the unknown parameters, introduced in the parameterization procedure, are the optimization variables. To solve the nonlinear optimization problem and find the optimal values of the control parameters, the Alienor global optimization method is used to achieve the global optimal values of the control law parameters. The proposed approach is illustrated by two application examples taken from the literature.
Everybody Will Win, and All Must Be Hired: Comparing Additivity Neglect with the Nonselective Superiority Bias
Authors: Riege Anine H. , Teigen Karl Halvor 
Published: November 2015

AbstractTwo streams of research looking at referent‐dependent judgments from slightly different angles are subadditivity research and research on the nonselective superiority bias. Both biases violate basic formal constraints: the probabilities of a set of exclusive events cannot add up to more than 100%, and a set of attractive candidates cannot all be rated as superior to the group mean. We examine in three experiments how these two biases are related, by asking the same participants to perform both kinds of tasks on the same material. Both biases appear to be widespread, even for sets where all alternatives are presented together, but they differ in the way they are affected by response format and experimental setup. Thus, presenting participants with an unbiased set of ratings will reduce but not normalize their probability estimates of the same alternatives; while presenting them with an unbiased (additive) set of probabilities will make most alternatives appear inferior to the group mean, inverting the superiority bias. Self‐reports reveal that additivity neglect and the nonselective superiority bias can be based on two main response‐strategies: (i) considering each alternative independently or (ii) comparing alternatives, while neglecting their complementarity. In both cases, assessments will be the outcome of a compromise between the perceived “absolute” merits of each alternative, its standing relative to referents, and properties of the response scale. Copyright © 2015 John Wiley & Sons, Ltd.
Construction of photodynamic‐effect immunofluorescence probes by a complex of quantum dots, immunoglobulin G and chlorin e6 and their application in HepG2 cell killing
Authors: Yan Zheng‐Yu , Wang Li‐Li , Fei Meng‐Ying , Liu Xin‐Ying , Su Yi‐Long , Du Qing‐Qing , Wu Sheng‐Mei 
Published: November 2015

AbstractIn this study, tri‐functional immunofluorescent probes (Ce6–IgG–QDs) based on covalent combinations of quantum dots (QDs), immunoglobulin G (IgG) and chlorin e6 (Ce6) were developed and their photodynamic ability to induce the death of cancer cells was demonstrated. Strategically, one type of second‐generation photosensitizer, Ce6, was first coupled with anti‐IgG antibody using the EDC/NHS cross‐linking method to construct the photosensitive immunoconjugate Ce6–IgG. Then, a complex of Ce6–IgG–QDs immunofluorescent probes was obtained in succession by covalently coupling Ce6–IgG to water soluble CdTe QDs. The as‐manufactured Ce6–IgG–QDs maintained the bio‐activities of both the antigen–antibody‐based tumour targeting effects of IgG and the photodynamic‐related anticancer activities of Ce6. By way of polyclonal antibody interaction with rabbit anti‐human epidermal growth factor receptor (anti‐EGFR antibody, N‐terminus), Ce6–IgG–QDs were labelled indirectly onto the surface of human hepatocarcinoma (HepG2) cells in cell recognition and killing experiments. The results indicated that the Ce6–IgG–QDs probes have excellent tumour cell selectivity and higher photosensitivity in photodynamic therapy (PDT) compared with Ce6 alone, due to their antibody‐based specific recognition and location of HepG2 cells and the photodynamic effects of Ce6 killed cells based on efficient fluorescence resonance energy transfer between QDs and Ce6. Copyright © 2015 John Wiley & Sons, Ltd.
ChemInform Abstract: Discovery of Novel Delafossite‐Type Compounds Composed of Copper(I) Lithium Titanium with Photocatalytic Activity for H2 Evolution under Visible Light.
Authors: Kato Hideki , Fujisawa Tsuyoshi , Kobayashi Makoto , Kakihana Masato 
Published: November 2015

AbstractNew delafossite‐type 3R‐ and 2H‐Cu(Li1/3Ti2/3)O2 are prepared by heat treatment of mixtures of Cu2O and Li4Ti5O12 in the presence of CuCl as a flux (quartz ampule, 873—973 K, 5—40 h).
ChemInform Abstract: An Oxofluoride Catalyst Comprised of Transition Metals and a Metalloid for Application in Water Oxidation.
Authors: Svengren Henrik , Hu Shichao , Athanassiadis Ioannis , Laine Tanja M. , Johnsson Mats 
Published: November 2015

AbstractBoth single crystals and ground powder of the solid solution (CoxNi1‐x) 3Sb4O6F6 exhibit catalytic activity for water oxidation, chemical resistance to wear after repeated in situ tests, and a mechanical hardness of 2.86 GPa using Vickers indentation test on single crystals.
ChemInform Abstract: Enantioselective Haloetherifications Catalyzed by 1,1′‐Bi‐2‐naphthol (BINOL) Phosphates: From Symmetrical Alkenediols to Simple Alkenols.
Authors: Mueller Christian H. , Roesner Christian , Hennecke Ulrich 
Published: November 2015

AbstractOptimized conditions are developed to permit the haloetherification of symmetrical (Z)‐ and (E)‐alkenediols using N‐halopyrrolidinones or NBS as halogen source and BINOL‐derived phosphates as catalyst.
ChemInform Abstract: Asymmetric Dearomatization of 1‐Aminonaphthalene Derivatives Through C—C Bond Formation with Electron‐Rich Heterocycles as Nucleophiles.
Authors: Baba Takafumi , Oka Junko , Noguchi Keiichi , Tanaka Ken 
Published: November 2015

AbstractThe gold catalyzed asymmetric intramolecular C—C bond forming reaction of 1‐aminonaphthalene derivatives provides access to pentacyclic heterocycles with low to moderate enantioselectivities.
ChemInform Abstract: Enantioselective Hydroalkynylation of Non‐Polar Carbon—Carbon Double Bonds: Iridium‐Catalyzed Asymmetric Addition Reaction of Terminal Alkyne C—H Bonds to Substituted Norbornadienes.
Authors: Yang Qingjing , Choy Pui Ying , Fan Baomin , Kwong Fuk Yee 
Published: November 2015

AbstractThe hydroalkynylation of azanorbornadienes catalyzed by an iridium system is reported for the first time.
ChemInform Abstract: Alkylation of Amines with Alcohols and Amines by a Single Catalyst under Mild Conditions.
Authors: Zou Qingzhu , Wang Chao , Smith Jen , Xue Dong , Xiao Jianliang 
Published: November 2015

AbstractAryl amines and aryldiamines as well as primary and secondary acyclic and cyclic amines are N‐alkylated with benzylic, primary and secondary alkyl alcohols including methanol.
ChemInform Abstract: Palladium(II)‐Catalyzed meta‐C—H Olefination: Constructing Multisubstituted Arenes Through Homo‐Diolefination and Sequential Hetero‐Diolefination.
Authors: Bera Milan , Maji Arun , Sahoo Santosh K. , Maiti Debabrata 
Published: November 2015

AbstractUsing an o‐cyanophenoxy group as directing group benzylsulfonic acid esters are olefinated in meta‐position by terminal and internal olefins.
ChemInform Abstract: A Safe and Scalable Synthesis of 2‐Hydroxy‐3‐alkoxypropionates by Epoxide Ring Opening.
Authors: Waring Michael J. , Bennett Stuart N. L. , Campbell Leonie , Hallam Stephen , Martin Nathaniel G. , Tickner Christopher 
Published: November 2015

AbstractPrimary, secondary, and tertiary alcohol nucleophiles are employed in the magnesium triflate catalyzed ring‐opening of epoxide (I) to form the title products in moderate yields.
ChemInform Abstract: A General Direct Arylation of Polyfluoroarenes with Heteroaryl and Aryl Chlorides Catalyzed by Palladium Indolylphosphine Complexes
Authors: Yuen On Ying , Charoensak Mueangkaew , So Chau Ming , Kuhakarn Chutima , Kwong Fuk Yee 
Published: November 2015

Abstractunder mild reaction conditions and a catalyst loading down to 1 mol% Pd
ChemInform Abstract: Copper‐Catalyzed C‐2 Arylation or Vinylation of Indole Derivatives with Iodonium Salts.
Authors: Liu Chuan , Zhang Wei , Dai Li‐Xin , You Shu‐Li 
Published: November 2015

AbstractDiaryliodonium salts are described as efficient reagents for the copper catalyzed 3‐arylation of 3‐functionalized indoles.
ChemInform Abstract: Use of 1‐Pentafluorosulfanyl‐phenylacetylenes for the Preparation of SF5‐Substituted Five‐Membered Ring Heterocycles Through 1,3‐Dipolar Cycloadditions. Isoxazoles and Isoxazolines.
Authors: Lopez Simon E. , Mitani Akira , Pena Priscila , Ghiviriga Ion , Dolbier William R. Jr. 
Published: November 2015

Abstract1,3‐Dipolar cycloaddition reactions of SF5‐substituted arylacetylenes with nitrile oxides generated in situ from (IV) or with nitrones (VI) affords isoxazole or isoxazoline derivatives of type (V) or (VII).
ChemInform Abstract: One‐Pot Synthesis of Phenanthridinones by Using a Base‐Catalyzed/Promoted Bicyclization of α,β‐Unsaturated Carbonyl Compounds with Dimethyl Glutaconate.
Authors: Li Lei , Chen Jia‐Jia , Kan Xing‐Lan , Zhang Lu , Zhao Yu‐Long , Liu Qun 
Published: November 2015

AbstractIn the base‐promoted reactions of compounds (VI) complete aromatization of the C‐ring is observed.
ChemInform Abstract: Facile and Efficient Synthesis of Pyrazoloisoquinoline and Pyrazolopyridine Derivatives Using Recoverable Carbonaceous Material as Solid Acid Catalyst.
Authors: Chen Zhu , Shi Yingxia , Shen Qingqing , Xu Haixia , Zhang Furen 
Published: November 2015

AbstractA novel procedure for the one‐pot condensation of aminopyrazoles, aldehydes, and cycloketones is developed using carbon functionalized with sulfonic acid groups as solid catalyst.
ChemInform Abstract: Synthesis of 2‐Triazolyl‐imidazo[1,2‐a]pyridine Through a One‐Pot Three‐Component Reaction Using a Nano Copper Oxide Assisted Click‐Catalyst.
Authors: Bagdi Prasanta Ray , Basha R. Sidick , Khan Abu T. 
Published: November 2015

AbstractThe synthesis of 2‐triazolyl imidazopyridine derivatives (IV) is accomplished by combined coupling reaction followed by 5‐exo dig cyclization of triazole carbaldehyde, amidine and terminal alkynes in the presence of nanocopper oxide and sodium ascorbate as a click‐catalyst.
ChemInform Abstract: Effective Synthesis of Quinoxalines over Ceria Based Solid Acids Coated on Honeycomb Monoliths.
Authors: Venkatesh Venkatesh , Shamshuddin S. Z. Mohamed , Mubarak N. M. 
Published: November 2015

AbstractThe solid acid, CeO2‐ZrO2 is found to be highly active in quinoxaline synthesis (III) with 100% selectivity.
ChemInform Abstract: Boron‐Catalyzed Regioselective Deoxygenation of Terminal 1,2‐Diols to 2‐Alkanols Enabled by the Strategic Formation of a Cyclic Siloxane Intermediate.
Authors: Drosos Nikolaos , Morandi Bill 
Published: November 2015

AbstractThe title reaction is also suitable for the selective deoxygenation of 1,2‐diol (VI).
ChemInform Abstract: One‐Pot Reductive N‐Vinylation and C(4)‐Phosphorylation of Pyridines with Alkylpropiolates and Secondary Phosphine Chalcogenides.
Authors: Gusarova Nina K. , Volkov Pavel A. , Ivanova Nina I. , Arbuzova Svetlana N. , Khrapova Kseniya O. , Albanov Alexander I. , Smirnov Vladimir I. , Borodina Tatyana N. , Trofimov Boris A. 
Published: November 2015

AbstractThe title reaction proceeds under mild conditions to form the corresponding products with high regio‐ and stereoselectivity.
ChemInform Abstract: Tetragonal Heusler‐Like Mn‐Ga Alloys Based Perpendicular Magnetic Tunnel Junctions
Authors: Ma Qinli , Sugihara Atsushi , Suzuki Kazuya , Zhang Xianmin , Miyazaki Terunobu , Mizukami Shigemi 
Published: November 2015

AbstractReview: 105 refs.
Schneiden und Bohren mit flüssigem Kohlendioxid
Authors: Engelmeier Lena , Kretzschmar Michael , Pollak Stefan , Weidner Eckhard 
Published: November 2015

AbstractWasserstrahlschneiden wird seit Jahrzehnten zum Schneiden verschiedener Werkstoffe eingesetzt. Allerdings können aufgrund der Nachteile dieser Methode nicht alle Materialien bearbeitet werden. Viele Nachteile können vermieden werden, wenn CO2 anstelle von Wasser verwendet wird. Dieses verdampft nach der Bearbeitung und ermöglicht einen trockenen, rückstandsfreien Schneidprozess. Vorgestellt wird ein Verfahren zum Strahlschneiden mit flüssigem Kohlendioxid und erste Ergebnisse von Schneidversuchen an verschiedenen Materialen.
Partner selection of agricultural products supply chain based on data mining
Authors: He Xuefeng , Ai Xingzheng , Jing Yuewu , Liu Yuanyuan 
Published: November 2015

SummaryNow, with the development of modern business, the traditional competition between enterprises has been displaced by the competition between supply chains. Any incorrect decision from supply chain member may have negative influences on other members or the whole supply chain. Therefore, choosing the appropriate supply chain partners is quite necessary and significant to the supply chain performance improvement because the partners can share risks and benefits with proper contract. Concentrating on the agricultural products supply chain, the supply chain partner selection model and indexes system are put forward in this paper, the clustering and classification analyses of potential supply chain partners are made by data mining technology, and the empirical analysis is made for agricultural products supply chain. This study may provide some insights into supply chain longitudinal governance and guidance for the Chinese agriculture economic development. Copyright © 2015 John Wiley & Sons, Ltd.
Citizen science in risk communication in the era of ICT
Authors: Kar Bandana 
Published: November 2015

SummaryRisk communication is the exchange of information among stakeholders about an impending disaster and its risks to help individuals take appropriate actions to mitigate hazard impacts. While traditional risk communication follows a command and control structure such that information from hierarchical and vertically integrated organizations is disseminated to broader community, social media uses a decentralized, collaborative, and network based communication approach. The growth of information and communication technologies has made social media a popular channel for disseminating alert and warning messages both by citizens and agencies. However, social media suffers from spreading rumors and hoaxes. To minimize rumors and increase citizen communication, a science gateway (Cyber‐Infrastructure for GeoInformatics and Community Resilience) has been deployed. This gateway, resulted from a research conducted along the Mississippi Gulf Coast communities, incorporates citizen science to evaluate warning message sources, message contents and dissemination channels to increase public response to warnings. This gateway built on the social construct of risk communication provides opportunities to citizens to share data and information about a hazard, and participate in building community resilience. Copyright © 2015 John Wiley & Sons, Ltd.
Isolation of a Tetranuclear Intermediate Complex in the Synthesis of Paddlewheel‐Type Dirhodium Tetraacetate
Authors: Kataoka Yusuke , Yano Natsumi , Kawamoto Tatsuya , Handa Makoto 
Published: November 2015

AbstractTo investigate the detailed mechanism of formation of the paddlewheel‐type dirhodium tetraacetate [Rh2(O2CCH3)4(L)2] ([1‐(L)2]; L = axial‐coordinated solvent ligand), we performed a step‐by‐step synthesis. The isolated red intermediate complex [Rh4(μ‐Cl)4(O2CCH3)4(L)4] ([2‐(L)4]) was characterized by means of single‐crystal X‐ray diffraction, 1H NMR spectroscopy, infrared spectroscopy, and elemental analysis. The crystal structure of [2‐(MeOH)4], which was crystallized from MeOH solution, has a unique twisted‐box Rh4(μ‐Cl)4 core coordinated by four μ‐carboxylato bridging ligands and four MeOH molecules as axially coordinated solvent molecules. The electronic structure and absorption properties of [2‐(MeOH)4] in MeOH were also carefully investigated both experimentally and theoretically.
Green Synthesis of a Microporous, Partially Fluorinated ZnII Paddlewheel Metal–Organic Framework: H2/CO2 Adsorption Behavior and Solid‐State Conversion to a ZnO–C Nanocomposite
Authors: Dhankhar Sandeep Singh , Kaur Manjodh , Nagaraja C. M. 
Published: November 2015

AbstractA microporous, partially fluorinated metal–organic framework consisting of ZnII dimeric paddlewheel units, formulated as [Zn(hfipbba)(4bpdb)0.5]·H2O (1) [hfipbba = 4,4′‐(hexaflouroisopropylene)bis(benzoic acid); 4bpdb = 1,4‐bis(4‐pyridyl)‐2,3‐diaza‐1,3‐butadiene], was synthesized by room‐temperature self‐assembly and characterized structurally by single‐crystal XRD. Compound 1 adopts a 3D microporous framework structure constituted by six‐connected ZnII dimeric paddlewheel nodes with {44.610.8}‐net topology. Further, rapid synthesis of phase‐pure 1 by green synthetic approaches such as mechanochemical and sonochemical routes was achieved. The 3D framework of 1 houses 1D helical channels with narrow pore dimensions of about 3.11 × 4.17 Å and exhibits interesting gas‐uptake (H2/CO2) properties. The isosteric heats of adsorption Qst for H2 and CO2 were estimated to be 8.8 and 36.4 kJ mol–1, respectively. Interestingly, solid‐state conversion of 1 to phase‐pure hexagonal ZnO nanocrystals of 6.1 ± 0.63 nm in size, embedded in carbonaceous layers to form a ZnO–C nanocomposite (NC), occurred on heating of 1 to 600 °C under vacuum for 2 h. The ZnO–C NC was characterized by XRD, UV/Vis, energy‐dispersive X‐ray, and TEM analyses. The as‐synthesized ZnO–C NC exhibits good photocatalytic activity for the degradation of methylene blue.