bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crystallographic and structural characterization of heterometallic platinum compounds. Part II. Heterobinuclear Pt compounds with Pt⋯M (M = transition or lantanide metal) > 3.0 Å
Authors: Melnik Milan , Sprusansky Ondrej , Holloway Clive 
Published: August 2012

Abstract
This review covers almost two hundred and twenty heterobinuclear platinum compounds in which Pt⋯M separation is over 3.0 Å. The M is a transition metal (Cu, Ag, Au, Ti, V, Cr, Mo, W, Mn, Re, Fe, Ru, Os, Co, Rh, Ir, Ni and Pd). There is an example of a lanthanide, Yb and a actinide, U. The Pt atom has oxidation numbers 0, +2 and +4. The Pt coordination geometries include trigonal planar Pt(0); square planar Pt(II); trigonal bipyramidal, and pseudo octahedral Pt(IV), with the most frequent being square planar. The most common ligands for Pt are P and C donor atoms, as well as a chlorine atom. The Pt — Ag distance of 3.002(1) Å is the shortest found in this series. There are examples which contain two crystallographically independent molecules, which differ mostly by degree of distortion and even one unique example, which contains eight such molecules. These are examples of distortion isomerism. Factors affecting bond lengths and angles are discussed and some ambiguities in coordination polyhedral are outlined.
Improved hydrothermal synthesis of MoS2 sheathed carbon nanotubes
Authors: Robles-Nuñez Jaciel , Chiñas-Castillo Fernando , Sanchez-Rubio Manuel , Lara-Romero Javier , Huirache-Acuña Rafael , Jimenez-Sandoval Sergio , Alonso-Nuñez Gabriel 
Published: August 2012

AbstractMoS2 sheathed carbon nanotubes have been successfully synthesized using a hydrothermal route under controlled conditions. The resultant material was studied by XRD, EDS, HRTEM, and Raman spectroscopy. Advantages of the preparation presented here compared to other methods are: a) lower reaction temperature, b) high yield of sheathed nanotubes including ends and full body, c) simple process with non-toxic materials, and d) no damage inflicted to nanotubes.
Quantitative analysis of two adulterants in Cynanchum stauntonii by near-infrared spectroscopy combined with multi-variate calibrations
Authors: Dong Wen-Jiang , Ni Yong-Nian , Kokot Serge 
Published: August 2012

AbstractAuthentication of traditional Chinese medicines (TCMs) has become important because they can be adulterated with relatively cheap herbal medicines similar in appearance. Detection of such adulterated samples is needed because their presence is likely to reduce the pharmacological potency of the original TCM and, in the worst cases, the samples may be harmful. The aim of this study was to develop a rapid near-infrared spectroscopy (NIRS) analytical method which was supported by multi-variate calibration, e.g. partial least squares regression (PLSR) and radial basis function artificial neural networks (RBF-ANN), in order to quantify the TCM and the adulterants. In this work, Cynanchum stauntonii (CS), a commonly used TCM, in mixtures with one or two adulterants — two morphological types of TCM, Cynanchum atrati (CA) and Cynanchum paniculati (CP), were determined using NIR reflectance spectroscopy. The three sample sets, CS adulterated with CA or CP, and CS with both CA and CP, were measured in the range of 800–2500 nm. Both PLSR and RBF-ANN calibration models provided satisfactory results, even at an adulteration level of 5 mass %, but the RBF-ANN models with better root mean square error of prediction (RMSEP) values for CS, CA, and CP arguably performed better. Consequently, this work demonstrates that the NIR method of sampling complex mixtures of similar substances such as CS adulterated by CA and/or CP is capable of producing data suitable for the quantitative analysis of mixtures consisting of the original TCM adulterated by one or two similar substances, provided the spectral data are interrogated by multi-variate methods of data analysis such as PLS or RBF-ANN.
Determination of pK a of benzoic acid- and p-aminobenzoic acid-modified platinum surfaces by electrochemical and contact angle measurements
Authors: Tekin-Celebi Secil , Solak Ali , Ustundag Zafer , Demirci Serkan 
Published: August 2012

AbstractAcidity constant values of benzoic acid (BA)-modified platinum electrode (Pt-BA) and p-aminobenzoic acid (pABA)-modified platinum electrode (Pt-NHBA) surfaces were determined using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and contact angle measurements (CAM). Diazonium tetrafluoroborate salt reduction and pABA oxidation reactions were used to prepare (Pt-BA) and (Pt-NHBA) surfaces, respectively. Both surfaces exhibited pH dependence with [Fe(CN)6]3−/4− redox probe solutions at different pH; this allowed us to estimate the surface pK a values. Acidity constants for Pt-BA surface were found to be pK a (3.09 ± 0.25), (4.89 ± 0.11), and (3.91 ± 0.54) by CV, EIS, and CAM techniques, respectively, while the values for Pt-NHBA surface were pK a (3.16 ± 0.45), (4.24 ± 0.40), and (5.64 ± 0.12). The Pt-BA surface pK a values were lower in CV and CAM measurements relative to the bulk solution of BA, while a higher value was observed in EIS for Pt-BA surface. The pK a values determined for Pt-NHBA surface via both CV and EIS were lower than the bulk value; however, the result obtained from CAM was one unit higher than pK a of bulk pABA.
Palladium-catalysed Claisen rearrangement of 6-allyloxypurines
Authors: Koukal Petr , Dvořáková Hana , Dvořák Dalimil , Tobrman Tomáš 
Published: August 2012

Abstract6-Allyloxypurines readily undergo palladium-catalysed Claisen rearrangement under mild conditions affording N 1-substituted hypoxanthines. In contrast with the previously reported protocol, the Claisen rearrangement can be performed using Pd(PPh3)4 or Pd(dba)2/dppf in dry THF at 60°C. The reaction can accommodate variously substituted allyl fragments to position N 1 of the hypoxanthine skeleton with high yields. Retention of the double bond configuration during rearrangement was observed.
Sixteen novel microsatellite markers developed for Dendrocalamus sinicus (Poaceae), the strongest woody bamboo in the world
Authors: Dong Yu‐Ran , Zhang Zhi‐Rong , Yang Han‐Qi 
Published: August 2012

• Premise of the study: Microsatellite primers were developed in the strongest and most economically important bamboo species, Dendrocalamus sinicus, to investigate its genetic variability.• Methods and Results: Using the Fast Isolation by AFLP of Sequences COntaining Repeats (FIASCO) protocol, 16 polymorphic primer sets were identified within 24 individuals from two geographic locations. The number of alleles per locus ranged from two to four, with a mean of 2.6. The observed and expected heterozygosities varied from 0 to 1.000 and from 0.311 to 0.754, respectively. The cross‐amplification of the 16 primer pairs was tested in four other Dendrocalamus species, and nine to 13 (56.3–81.3%) primer pairs were successfully amplified.• Conclusions: These markers will be useful for studies on the genetic diversity of D. sinicus, which may facilitate conservation of this species.
Development of 35 microsatellite markers from heat stress transcription factors in Populus simonii (Salicaceae)
Authors: Wang Lu , Wang Bao‐Lei , Wei Zun‐Zheng , Du Qing‐Zhang , Zhang De‐Qiang , Li Bai‐Lian 
Published: August 2012

• Premise of the study: Microsatellite markers within regulators of heat stress transcription factors were identified in the Populus trichocarpa genome, and then developed for P. simonii to investigate the genetic diversity of germplasm resources and to further identify favorable alleles significantly associated with stress‐resistant traits.• Methods and Results: Thirty‐five novel microsatellite markers were identified from genes controlling heat stress transcription factors in P. simonii using a Sanger sequencing protocol. Polymorphisms in 48 individuals from 16 populations of P. simonii revealed that the number of alleles per locus ranged from two to nine with an average of 4.6; the observed heterozygosity and expected heterozygosity per locus varied from 0.143 to 0.857 and from 0.257 to 0.948, respectively.• Conclusions: The new polymorphic markers developed during this study will facilitate the construction of genetic linkage maps and will aid in marker‐assisted breeding of a new germplasm with desirable abiotic stress resistance in Populus species.
Lacan's dismanteling of his clinic
Authors: Allouch Jean 
Published: August 2012

Distinguée par Michel Foucault sous le nom de « fonction psy », la prégnance du discours psychologisant dans la cité est désormais d’une emprise telle en Occident qu’il apparaît presque naturel que le pouvoir, quel qu’il soit, s’adresse aux supposés détenteurs de ce discours lorsque vient au jour une question dite « de société ». On indique qu’à cet endroit le psychanalyste, lui en tout cas, ne peut que s’abstenir. Également qu’une telle abstention est interne à son exercice ; elle y prend ses racines dans un refus actif, quand il s’agit d’accueillir quelqu’un, d’user de quelque grille nosographique que ce soit, autrement dit de cataloguer.
Sexuality and disfiguration: from 19th century medical theories to psychoanalytic's infantile sexual theories
Authors: Linhares Andréa 
Published: August 2012

La littérature médicale du début du XIXe siècle établissait de façon récurrente un lien entre anatomie et préférences sexuelles. Selon nombre de médecins de cette époque, l’idée de la défiguration corporelle était articulée à des pratiques sexuelles déviantes. Elle était tantôt envisagée comme la cause des désirs interdits, tantôt comme la conséquence physique visible des rapports sexuels illicites. Ces conceptions historiques du corps et du sexe peuvent-elles apporter un éclairage sur certaines expériences recueillies dans la clinique analytique ? Tel est le pari de cet article. En effet, dès lors qu’elles se réfèrent aux désirs refoulés, du moins socialement, ces théorisations anatomo-pathologiques peuvent fonctionner comme un terrain privilégié pour le déploiement des fantasmes inconscients. Chez les médecins du XIX e siècle, l’idée de la défiguration venait rendre visibles les traces des pratiques sexuelles qui devaient rester invisibles en société (masturbation, pédérastie et saphisme). De la même manière, certaines situations cliniques laisseraient penser que le fantasme de défiguration vient donner une forme corporelle à des positions psychiques angoissantes, de par leur contenu sexuel refoulé. Comme si, afin d’être circonscrits et contenus, l’excès et le désordre pulsionnels du retour du refoulé appelaient la construction psychique d’une figure du corps.
In praise of subjectivity in psychiatry
Authors: Dimitriadis Yorgos 
Published: August 2012

La subjectivité du malade est systématiquement méconnue par la médecine depuis surtout qu’elle est devenue scientifique – à savoir depuis le début du XIXe siècle. La psychiatrie doit être, encore plus que le reste de la médecine, orientée vers le sujet malade plutôt que vers la maladie, mais l’exigence de scientificité la pousse de plus en plus vers l’exclusion de la subjectivité, tant celle du malade que celle du clinicien. De nos jours, le sujet est de plus en plus confondu avec son cerveau, et tout un discours neuroscientifique infiltre notre façon d’apercevoir l’individualité et notre rapport à la jouissance. La psychiatrie, même dans ses applications biologiques, doit tenir compte du fait que l’homme est un être parlant, ce qui signifie qu’il entretient un rapport particulier à son corps qui, par conséquent, est « dénaturalisé » ; de ce fait, le sujet ne saurait être confondu avec son cerveau.
Destins du corps et subjectivité dans une clinique sociale
Authors: Benhaïm Michèle 
Published: August 2012

Ce texte étudie trois temps logiques de la réinsertion sociale et surtout psychique à partir d’une pratique de clinique de rue : le premier temps recouvre l’espace de la rencontre dans la rue sur deux ans, le deuxième temps est celui de l’après-rue, temps au cours duquel émergent les points traumatiques suivis d’éventuelles décompensations, le troisième temps est celui où les sujets s’apaisent et se mettent à élaborer des demandes, en l’occurrence celles de comprendre ce qui les a menés dans la rue. L’objectif de ce texte est de construire une position clinique possible dans ces lieux (de) l’extrême.
A Sphingosine-1-Phosphate Receptor 1-Directed Agonist Reduces Central Nervous System Inflammation in a Plasmacytoid Dendritic Cell-Dependent Manner
Authors: Galicia-Rosas Georgina , Pikor Natalia , Schwartz Jordan A. , Rojas Olga , Jian Allen , Summers-Deluca Leslie , Ostrowski Mario , Nuesslein-Hildesheim Barbara , Gommerman Jennifer L. 
Published: August 2012

Abstract
Gradients of the sphingolipid sphingosine-1-phosphate (S1P) are responsible for the egress of lymphocytes from lymph nodes by activating the S1P1 receptor expressed on the surface of lymphocytes. Small molecule drugs that downregulate S1P receptors induce the sequestration of lymphocytes within lymph nodes, thus preventing lymphocytes from accessing sites of inflammation. In particular, FTY720, a pan-S1P receptor agonist, has been efficacious in the treatment of multiple sclerosis as well as its animal model, experimental autoimmune encephalomyelitis (EAE), by virtue of its ability to restrain lymphocytes within the lymph nodes, thus precluding their migration into the CNS. However, multiple leukocyte subsets express S1P receptors of varying types, and although it is beneficial to prevent transmigration of proinflammatory lymphocytes into the CNS, allowing access of regulatory leukocyte subsets to the CNS is desirable. In this study, we show that an S1P1-specific agonist (AUY954) is clinically efficacious in ameliorating pre-established EAE in SJL/J mice. Efficacy of AUY954 correlated with a reduction of lymphocytes in the CNS, but access of plasmacytoid dendritic cells (pDCs) to the CNS was unimpaired, and the presence of pDCs was found to be an important cofactor in mediating the clinical efficacy of AUY954. These results indicate that pDCs are important in quieting autoimmune responses during EAE, and that trafficking inhibitors that are permissive for pDC accumulation in the CNS may be of therapeutic value for the treatment of multiple sclerosis.
IRF4 Promotes Cutaneous Dendritic Cell Migration to Lymph Nodes during Homeostasis and Inflammation
Authors: Bajaña Sandra , Roach Kimberly , Turner Sean , Paul Jinny , Kovats Susan 
Published: August 2012

Abstract
Migration of resident dendritic cells (DC) from the skin to local lymph nodes (LN) triggers T cell-mediated immune responses during cutaneous infection, autoimmune disease, and vaccination. In this study, we investigated whether the development and migration of skin-resident DC were regulated by IFN regulatory factor 4 (IRF4), a transcription factor that is required for the development of CD11b+ splenic DC. We found that the skin of naive IRF4−/− mice contained normal numbers of epidermal Langerhans cells (eLC) and increased numbers of CD11b+ and CD103+ dermal DC (dDC) populations, indicating that tissue DC development and skin residency is not disrupted by IRF4 deficiency. In contrast, numbers of migratory eLC and CD11b+ dDC were significantly reduced in the cutaneous LN of IRF4−/− mice, suggesting a defect in constitutive migration from the dermis during homeostasis. Upon induction of skin inflammation, CD11b+ dDC in IRF4−/− mice did not express the chemokine receptor CCR7 and failed to migrate to cutaneous LN, whereas the migration of eLC was only mildly impaired. Thus, although dispensable for their development, IRF4 is crucial for the CCR7-mediated migration of CD11b+ dDC, a predominant population in murine and human skin that plays a vital role in normal and pathogenic cutaneous immunity.
IL-2 and IL-7 Determine the Homeostatic Balance between the Regulatory and Conventional CD4+ T Cell Compartments during Peripheral T Cell Reconstitution
Authors: Le Campion Armelle , Pommier Arnaud , Delpoux Arnaud , Stouvenel Laurence , Auffray Cédric , Martin Bruno , Lucas Bruno 
Published: August 2012

Abstract
Work over the last decades has led to the identification of the factors that influence the survival and homeostasis of conventional T cells. IL-7 and TCR signaling promote the survival of naive CD4+ and CD8+ T cells in lymphoreplete mice and their proliferation in a lymphopenic environment, whereas survival and homeostatic proliferation of memory CD4+ and CD8+ T cells crucially depend on a combination of IL-7 and IL-15. In contrast, there is little information regarding the factors driving the proliferation of regulatory CD4+ T cells in response to lymphopenia. In this study, we investigated whether regulatory CD4+ T cell proliferation in response to lymphopenia was guided by classical homeostatic resources, such as IL-2, IL-7, or TCR–MHC interactions. Altogether, our data suggest that, although homeostatic proliferation of conventional naive CD4+ T cells is closely related to IL-7 levels, the proliferation of regulatory CD4+ T cells in response to lymphopenia appears to be primarily controlled by IL-2. The capacity of IL-7 to augment conventional T cell proliferation with minimal concomitant regulatory T cell expansion may be clinically exploitable in the treatment of patients with lymphopenia, especially in the case of chronic viral diseases or cancer immunotherapy.
Human Lupus Serum Induces Neutrophil-Mediated Organ Damage in Mice That Is Enabled by Mac-1 Deficiency
Authors: Rosetti Florencia , Tsuboi Naotake , Chen Kan , Nishi Hiroshi , Ernandez Thomas , Sethi Sanjeev , Croce Kevin , Stavrakis George , Alcocer-Varela Jorge , Gómez-Martin Diana , van Rooijen Nico , Kyttaris Vasileios C. , Lichtman Andrew H. , Tsokos George C. , Mayadas Tanya N. 
Published: August 2012

Abstract
Systemic lupus erythematosus (SLE) is a chronic, multiorgan inflammatory autoimmune disorder associated with high levels of circulating autoantibodies and immune complexes. We report that passive transfer of human SLE sera into mice expressing the uniquely human FcγRIIA and FcγRIIIB on neutrophils induces lupus nephritis and in some cases arthritis only when the mice additionally lack the CD18 integrin, Mac-1. The prevailing view is that Mac-1 on macrophages is responsible for immune complex clearance. However, disease permitted by the absence of Mac-1 is not related to enhanced renal immune complex deposition or in situ C1q/C3 complement activation and proceeds even in the absence of macrophages. Instead, disease is associated with increased FcγRIIA-induced neutrophil accumulation that is enabled by Mac-1 deficiency. Intravital microscopy in the cremasteric vasculature reveals that Mac-1 mitigates FcγRIIA-dependent neutrophil recruitment in response to deposited immune complexes. Our results provide direct evidence that human SLE immune complexes are pathogenic, demonstrate that neutrophils are primary mediators of end organ damage in a novel humanized lupus mouse model, and identify Mac-1 regulation of FcγRIIA-mediated neutrophil recruitment as a key step in development of target organ damage.
The β-Glucan Receptor Dectin-1 Promotes Lung Immunopathology during Fungal Allergy via IL-22
Authors: Lilly Lauren M. , Gessner Melissa A. , Dunaway Chad W. , Metz Allison E. , Schwiebert Lisa , Weaver Casey T. , Brown Gordon D. , Steele Chad 
Published: August 2012

Abstract
Sensitization to fungi, such as the mold Aspergillus fumigatus, is increasingly becoming linked with asthma severity. We have previously shown that lung responses generated via the β-glucan receptor Dectin-1 are required for lung defense during acute, invasive A. fumigatus infection. Unexpectedly, in an allergic model of chronic lung exposure to live A. fumigatus conidia, β-glucan recognition via Dectin-1 led to the induction of multiple proallergic (Muc5ac, Clca3, CCL17, CCL22, and IL-33) and proinflammatory (IL-1β and CXCL1) mediators that compromised lung function. Attenuated proallergic and proinflammatory responses in the absence of Dectin-1 were not associated with changes in Ido (IDO), Il12p35/Ebi3 (IL-35), IL-10, or TGF-β levels. Assessment of Th responses demonstrated that purified lung CD4+ T cells produced IL-4, IL-13, IFN-γ, and IL-17A, but not IL-22, in a Dectin-1–dependent manner. In contrast, we observed robust, Dectin-1–dependent IL-22 production by unfractionated lung digest cells. Intriguingly, the absence of IL-22 alone mimicked the attenuated proallergic and proinflammatory responses observed in the absence of Dectin-1, suggesting that Dectin-1–mediated IL-22 production potentiated responses that led to decrements in lung function. To this end, neutralization of IL-22 improved lung function in normal mice. Collectively, these results indicate that the β-glucan receptor Dectin-1 contributes to lung inflammation and immunopathology associated with persistent fungal exposure via the production of IL-22.
Gestión universitaria: un enfoque holístico
Authors: Tamayo Horacio V. Barreda 
Published: August 2012

Un breve análisis comparativo de los resultados y características de las universidades en el Perú (Censo Universitario 2010); con referencia a las mejores universidades a nivel internacional (Oppenheimer, 2010). Nos permite alertar a la conciencia nacional, sobre la necesidad de hacer un cambio en la gestión universitaria vigente. De no hacer nada, podemos afirmar que a futuro vamos a estar peor que ahora, porque aumentará la brecha negativa. Para lograr mejores resultados a mediano plazo, se propone un enfoque holístico de la gestión universitaria. El enfoque holístico propuesto, considera dos niveles de gestión, uno a nivel macro y otro a nivel micro. La macro gestión universitaria vincula los resultados de la educación universitaria con el desarrollo sostenible de cada País y la educación en general. La micro gestión universitaria, es la que debe desarrollarse al interior de cada Institución a nivel funcional.
Gestão integrada de resíduos sólidos para instituições públicas de ensino superior
Authors: Juliatto Dante Luiz , Calvo Milena Juarez , Cardoso Thaianna Elpídio 
Published: August 2012

Este texto apresenta uma discussão a respeito da problemática resíduos sólidos frente à recente Lei Federal 12.305/2010, quanto à proposta de instrumentos para a gestão em Instituições Públicas e como tem se dado este enfrentamento em Universidades Públicas e órgãos de sua administração. Tem-se como objetivo a proposta de uma sistematização de procedimentos integrados, a partir de uma visão complexa desta realidade específica. A realização do estudo de caso na Universidade Federal de Santa Catarina culmina para consolidação de um modelo de gestão, que venha ajustar às legislações vigentes, possibilitando a sua adaptação à cultura da sustentabilidade. Para isto, aborda-se o papel fundamental das universidades como laboratório de idéias na constante busca por soluções, aliada às demais leis para o desenvolvimento sustentável.