bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Australasian Maternity Outcomes Surveillance System: An evaluation of stakeholder engagement, usefulness, simplicity, acceptability, data quality and stability
Authors: Halliday Lesley E. , Peek Michael J. , Ellwood David A. , Homer Caroline , Knight Marion , Mclintock Claire , Jackson‐Pulver Lisa , Sullivan Elizabeth A. 
Published: December 2012

BackgroundThe Australasian Maternity Outcomes Surveillance System (AMOSS) conducts active, prospective surveillance of severe maternal conditions in Australia and New Zealand (ANZ). AMOSS captures greater than 96% of all births, and utilises an online, active case‐based negative reporting system.AimTo evaluate AMOSS using the United States Centres for Disease Control (MMWR 2001; 50 (RR13): 1–35.) surveillance system evaluation framework.MethodsData were gathered using multiple methods, including an anonymous online survey administered to 353 AMOSS data collectors, in addition to review of case data received during 2009–2011, documented records of project board and advisory group meeting minutes, publications, annual reports and the AMOSS database.ResultsAMOSS is a research system characterised by its simplicity and efficiency. The socio‐demographic, risk factor and severe morbidity clinical data collected on rare conditions are not duplicated in other routine data systems. AMOSS is functioning well and has sustained buy‐in from clinicians, stakeholders and consumers and a high level of acceptability to data collectors in ANZ maternity units.ConclusionsAMOSS is the only existing national system of surveillance for rare and severe maternal conditions in ANZ and therefore serves an important function, utilising data collected from reliable sources, in an effective, efficient and timely way.
Antagonism of P2Y1‐induced vasorelaxation by acyl CoA: a critical role for palmitate and 3′‐phosphate
Authors: Alefishat E , Alexander SPH , Ralevic V 
Published: December 2012

Background and PurposeAcyl derivatives of CoA have been shown to act as antagonists at human platelet and recombinant P2Y1 receptors, but little is known about their effects in the cardiovascular system. This study evaluated the effect of these endogenous nucleotide derivatives at P2Y1 receptors natively expressed in rat and porcine blood vessels.Experimental ApproachIsometric tension recordings were used to evaluate the effects of CoA, acetyl CoA, palmitoyl CoA (PaCoA) and 3′‐dephospho‐palmitoyl‐CoA on concentration relaxation–response curves to ADP and uridine triphosphate (UTP). A FlexStation monitored ADP‐ and UTP‐evoked calcium responses in HEK293 cells.Key ResultsAcetyl CoA and PaCoA, but not CoA, inhibited endothelium‐dependent relaxations to ADP with apparent selectivity for P2Y1 receptors (over P2Y2/4 receptors) in rat thoracic aorta; PaCoA was more potent than acetyl CoA (331‐fold vs. fivefold shift of ADP response curve evoked by 10 μM PaCoA and acetyl CoA, respectively); the apparent pA2 value for PaCoA was 6.44. 3′‐dephospho‐palmitoyl‐CoA (10 μM) was significantly less potent than PaCoA (20‐fold shift). In porcine mesenteric arteries, PaCoA and the P2Y1 receptor antagonist MRS2500 blocked ADP‐mediated endothelium‐dependent relaxations; in contrast, they were ineffective against ADP‐mediated endothelium‐independent relaxation in porcine coronary arteries (which does not involve P2Y1 receptors). Calcium responses evoked by ADP activation of endogenous P2Y1 receptors in HEK293 cells were inhibited in the presence of PaCoA, which failed to alter responses to UTP (acting at endogenous P2Y2/4 receptors).Conclusions and ImplicationsAcyl derivatives of CoA can act as endogenous selective antagonists of P2Y1 receptors in blood vessels, and this inhibitory effect critically depends on the palmitate and 3′‐ribose phosphate substituents on CoA.
Implications of new European Union driving regulations on patients with Type 1 diabetes who participated in the Diabetes Control and Complications Trial
Authors: Kilpatrick E. S. , Rigby A. S. , Warren R. E. , Atkin S. L. 
Published: December 2012

AbstractAimsRecurrent severe hypoglycaemia in a patient with diabetes is strongly associated with a crash risk while driving. To help ensure road safety, recent changes were made to European Union driving regulations for patients with diabetes. These included the recommendation that more than one episode of severe hypoglycaemia within 12 months would lead to the loss of a driving licence. This study has assessed the impact of this regulation if applied to patients who participated in the Diabetes Control and Complications Trial.MethodsAll patients in the Diabetes Control and Complications Trial were assumed to be drivers. Repeated hypoglycaemic episodes within a year were determined during the mean 6.5 years of the study.ResultsOf the 1441 patients in the Diabetes Control and Complications Trial, 439 (30%) had more than one severe hypoglycaemic episode during a 12‐month period of their study participation. Amongst the study groups, 312/711 (44%) of intensively treated and 127/730 (17%) of conventionally treated patients would have lost their licence at some point during the trial. The risk of licence loss increased with lower mean HbA1c, longer duration of diabetes and younger age (all P < 0.001).ConclusionsMore than one episode of severe hypoglycaemia within a year was a frequent event in subjects in the Diabetes Control and Complications Trial, especially in intensively treated patients. If applied to current practice, improving road safety through these changes to European Union regulations could have a substantial impact on drivers who have Type 1 diabetes. This emphasizes the need to take into account the potential effects of severe hypoglycaemia in those who rely on a driving licence.
Chinese overseas M&A performance and the Go Global policy1
Authors: Gu Lulu , Reed W.R. 
Published: December 2012

AbstractIt is well known that government plays an important role in the business activities of Chinese firms. Less certain is the effect this influence has on the wealth of those firms’ shareholders. We contribute to the literature by analysing stock market reactions to announcements by Chinese firms of overseas mergers and acquisitions (OMAs). OMAs are of particular interest because there can exist a conflict between the interests of the public sector in acquiring overseas assets, and the interests of the private sector in maximizing shareholder wealth. Our main dataset consists of 213 observations of 157 OMA events that occurred between 1994 and 2009, using share market returns from the Shanghai, Shenzhen, Hong Kong and US markets. The aggregation of share price data across multiple markets, and the listing of firms in multiple exchanges, raise econometric issues for the standard event‐study methodology. To address these, we use a new, feasible generalized least squares (GLS) procedure developed by Gu and Reed (2012). On the basis of an analysis using both aggregated and disaggregated samples, and of daily and cumulative abnormal returns, we find consistent evidence that (i) Chinese OMAs have not lowered the wealth of shareholders of Chinese acquiring firms, and (ii) shareholders of Chinese acquiring firms have not fared worse under under China's ‘Go Global’ policy of encouraging outward investment by Chinese firms.
IgG‐Based Elimination Diet in Migraine Plus Irritable Bowel Syndrome
Authors: Aydinlar Elif Ilgaz , Dikmen Pinar Yalinay , Tiftikci Arzu , Saruc Murat , Aksu Muge , Gunsoy Hulya G. , Tozun Nurdan 
Published: December 2012

Objectives.To evaluate therapeutic potential of the immunoglobulin G (IgG)‐based elimination diet among migraine patients with irritable bowel syndrome (IBS).Background.Food elimination has been suggested as an effective and inexpensive therapeutic strategy in patients with migraine and concomitant IBS in the past studies.Methods.A total of 21 patients (mean [standard deviation] age: 38.0 [11.2] years; 85.7% females) diagnosed with migraine and IBS were included in this double‐blind, randomized, controlled, cross‐over clinical trial composed of baseline (usual diet), first diet (elimination or provocation diets), and second diet (interchange of elimination or provocations diets) phases and 4 visits.Results.IgG antibody tests against 270 food allergens revealed mean (standard deviation) reaction count to be 23.1 (14.1). Compared with baseline levels, elimination diet per se was associated with significant reductions in attack count (4.8 [2.1] vs 2.7 [2.0]; P < .001), maximum attack duration (2.6 [0.6] vs 1.4 [1.1] days; P < .001), mean attack duration (1.8 [0.5] vs 1.1 [0.8] days; P < .01), maximum attack severity (visual analog scale 8.5 [1.4] vs visual analog scale 6.6 [3.3]; P < .001), and number of attacks with acute medication (4.0 [1.5] vs 1.9 [1.8]; P < .001). There was a significant reduction in pain‐bloating severity (1.8 [1.3] vs 3.2 [0.8]; P < .05), pain‐bloating within the last 10 days (3.2 [2.8] vs 5.5 [3.1]; P < .05), and improvement obtained in quality of life (3.6 [1.4] vs 2.9 [1.0]; P < .05) by the elimination diet as compared with provocation diet.Conclusions.Our findings indicate that food elimination based on IgG antibodies in migraine patients who suffer from concomitant IBS may effectively reduce symptoms from both disorders with possible positive impact on the quality of life of the patients as well as potential savings to the health‐care system.
Effects of Rotation and Osteotomy Angulation on Patellar Tendon Insertion Position during Circular Tibial Tuberosity Osteotomy
Authors: Rovesti Gian Luca , Katic Nikola , Dalpozzo Boris , Dondi Francesco , Dupré Gilles 
Published: December 2012

ObjectiveTo evaluate the influence of rotation of the tibial tuberosity (TT) in the sagittal plane and angulation of osteotomy in the frontal plane (FPA) on the displacement of patellar tendon (PT) insertion.Study DesignEx vivo biomechanical study.Sample PopulationCanine tibiae (n = 36).MethodsNine groups of 4 tibiae each had a circular osteotomy of the TT at an FPA from –20° to +20° with increments of 5° for each group. The osteotomized TT was rotated by angles of rotation (AORs) of 10°, 20°, or 30° in the sagittal plane. The craniocaudal (CCD), distoproximal (DPD), and mediolateral (MLD) displacements of a marker located at the PT insertion on the TT were evaluated radiographically. Differences between groups were analyzed by Mann–Whitney U test and Friedman 2‐way ANOVA.ResultsThere was a significant correlation between the AOR and CCD. A positive FPA resulted in a high CCD and lateral shift of the TT at every AOR. Performing an osteotomy at an FPA of 0° produced the maximum amount of DPD.ConclusionsFPA and AOR during circular osteotomy of the TT influence the final displacement of the PT insertion in all 3 planes.
The Effect of Short‐ and Long‐Term Treatment with Manuka Honey on Second Intention Healing of Contaminated and Noncontaminated Wounds on the Distal Aspect of the Forelimbs in Horses
Authors: Bischofberger Andrea S. , Dart Christina M. , Perkins Nigel R. , Kelly Ashley , Jeffcott Leo , Dart Andrew J. 
Published: December 2012

ObjectivesTo compare the effects of manuka honey and manuka honey gel on second intention healing of noncontaminated distal limb wounds and those contaminated with feces.Study DesignExperimental study.AnimalsStandardbred horses (n = 10).MethodsFive full‐thickness wounds (2 × 2 cm) were created on both metacarpi. Wounds on 1 forelimb were covered with horse feces for 24 hours. Wounds on the contralateral limb were left uncontaminated. Wounds were assigned to the following 5 different treatments: manuka honey, manuka honey gel or gel applied for 12 days, manuka honey gel applied throughout healing and untreated control. Wound area was measured on day 1 then weekly until day 42 and time to complete healing was recorded.ResultsWounds treated with manuka honey gel throughout healing healed faster than all other wounds (P< .05). Wounds treated with manuka honey and manuka honey gel for 12 days healed faster than gel control and untreated control wounds (P< .05). Wounds treated with manuka honey and manuka honey gel for 12 days and throughout healing were smaller than gel control and untreated control wounds until day 35 (P< .05). Wounds contaminated with feces had greater retraction for 7 days, but healed faster than noncontaminated wounds (P< .05).ConclusionsTreatment of wounds with manuka honey and manuka honey gel reduced wound retraction and overall healing time compared with gel and untreated control wounds.
Who Plays the Key Role among Shanghai, Shenzhen and Hong Kong Stock Markets?
Authors: Wang Jian , Zhu Junfeng , Dou Feifei 
Published: December 2012

AbstractIn this paper we examine the daily frequency stock market indices of Shanghai, Shenzhen and Hong Kong from January 2000 to June 2012, and use the Morlet wavelet coherence model to determine who is playing the most important role in the financial markets of China. We find that there are significant comovements between these stock markets in the medium and long run. This provides investors with opportunities to increase their capital gains. The Hong Kong stock market plays a leading role in the long run, but its leader position is threatened by fast‐growing Chinese mainland stock markets, especially the Shanghai Stock Exchange. Based on our analysis, the following suggestions apply to the Chinese stock markets: establish and improve international and regional finance centers in Chinese mainland; encourage more qualified institutional investors; reposition the market relations among Hong Kong, Shanghai and Shenzhen; and increase deregulation and internationalization to speed up the integration of financial resources.
No relation between sleep duration and adiposity indicators in 9–36 months old children: the SKOT cohort
Authors: Klingenberg L. , Christensen L. B. , Hjorth M. F. , Zangenberg S. , Chaput J.‐P. , Sjödin A. , Mølgaard C. , Michaelsen K. F. 
Published: December 2012

SummaryBackgroundEpidemiological studies in adults and children have repeatedly reported an association between short sleep duration and the risk of obesity. Studies using both objective measurements of sleep and dual‐energy X‐ray absorptiometry in children aged three are, however, lacking.ObjectiveThe study aims to examine both the longitudinal and cross‐sectional associations between sleep duration and adiposity indicators in children aged 3 and younger.MethodsOn a cohort of 311 infants born at term, we used parent‐reported sleep duration at 9 months, 18 months and 3 years of age, and accelerometer estimated nocturnal sleep duration at 3 years of age. Sleep duration at 9 and 18 months were used to predict adiposity at 3 years of age.ResultsWe found no associations between any of the adiposity indicators at 3 years of age and (i) parent‐reported total sleep duration at 9 months, 18 months and 3 years, and (2) nocturnal sleep duration measured with accelerometry at 3 years of age. Multivariate adjustments were used in both approaches.ConclusionOur results do not support the hypothesis that short sleep duration is associated with increased adiposity in this cohort of young Danish children.
Non‐bacterial protein expression in periodontal pockets by proteome analysis
Authors: Bertoldi Carlo , Bellei Elisa , Pellacani Chiara , Ferrari Davide , Lucchi Andrea , Cuoghi Aurora , Bergamini Stefania , Cortellini Pierpaolo , Tomasi Aldo , Zaffe Davide , Monari Emanuela 
Published: December 2012

AbstractObjectivesTo compare the proteomic profile of inter‐proximal pocket tissues with inter‐proximal healthy tissues in the same subject to reveal proteins associated with periodontal disease in sites where periodontopathogenic bacteria were not detectable.MethodsTwenty‐five healthy patients, with moderate‐to‐advanced chronic periodontitis and presenting with at least one intra‐bony defect next to a healthy inter‐proximal site were enrolled. The periodontal defects were treated with osseous resective surgery, and the flap design included both the periodontal pockets and the neighbouring inter‐proximal healthy sites. Pocket‐associated and healthy tissues were harvested for proteomic analyses.ResultsFifteen proteins were differently expressed between pathological and healthy tissues. In particular, annexin A2, actin cytoplasmic 1, carbonic anhydrase 1 & 2; Ig kappa chain C region (two spots) and flavinreductase were overexpressed, whereas 14‐3‐3 protein sigma and zeta/delta, heat‐shock protein beta ‐1 (two spots), triosephosphateisomerase, peroxiredoxin‐1, fatty acid‐binding protein‐epidermal, and galectin‐7 were underexpressed in pathological tissue.ConclusionsThe unbalanced functional network of proteins involved could hinder adequate tissue response to pathogenic noxa. The study of periodontal pocket tissue proteomic profile would be crucial to better understand the pathogenesis of and the therapeutic strategies for periodontitis.
Hemin ameliorates indomethacin‐induced small intestinal injury in mice through the induction of heme oxygenase‐1
Authors: Yoriki Hiroyuki , Naito Yuji , Takagi Tomohisa , Mizusima Katsura , Hirai Yasuko , Harusato Akihito , Yamada Shinya , Tsuji Toshifumi , Kugai Munehiro , Fukui Akifumi , Higashimura Yasuki , Katada Kazuhiko , Kamada Kazuhiro , Uchiyama Kazuhiko , Handa Osamu , Yagi Nobuaki , Ichikawa Hiroshi , Yosikawa Toshikazu 
Published: December 2012

AbstractBackground and AimAlthough non‐steroidal anti‐inflammatory drugs can induce intestinal injury, the mechanisms are not fully understood, and treatment has yet to be established. Heme oxygenase‐1 (HO‐1) has recently gained attention for anti‐inflammatory and cytoprotective effects. This study aimed to investigate the effects of hemin, an HO‐1 inducer, on indomethacin‐induced enteritis in mice.MethodsEnteritis was induced by single subcutaneous administration of indomethacin (10 mg/kg) in male C57BL/6 mice. Hemin (30 mg/kg) was administered by intraperitoneal administration 6 h before indomethacin administration. Mice were randomly divided into four groups: (i) sham + vehicle; (ii) sham + hemin; (iii) indomethacin + vehicle; or (iv) indomethacin + hemin. Enteritis was evaluated by measuring ulcerative lesions. Myeloperoxidase activity was measured as an index of neutrophil accumulation. The mRNA expression of inflammatory cytokines and chemokines, such as tumor necrosis factor‐α, monocyte chemoattractant protein‐1, macrophage inflammatory protein‐1α, and keratinocyte chemoattractant, were analyzed by real‐time polymerase chain reaction.ResultsThe area of ulcerative lesions, myeloperoxidase activity, and mRNA expression of inflammatory cytokines and chemokines were significantly increased in mice administrated with indomethacin compared with vehicle‐treated sham mice. Development of intestinal lesions, increased levels of myeloperoxidase activities, and mRNA expressions of inflammatory cytokines and chemokines were significantly suppressed in mice treated with hemin compared with vehicle‐treated mice. Protective effects of hemin were reversed by co‐administration of tin protoporphyrin, an HO‐1 inhibitor.ConclusionsInduction of HO‐1 by hemin inhibits indomethacin‐induced intestinal injury through upregulation of HO‐1. Pharmacological induction of HO‐1 may offer a novel therapeutic strategy to prevent indomethacin‐induced small intestinal injury.
Insulin resistance and inflammation markers: correlations in obese adolescents
Authors: Aguilar María J , González‐Jiménez Emilio , Antelo Aránzazu , Perona Javier S 
Published: December 2012

Aims and objectivesTo ascertain whether inflammation markers also correlate with parameters related to insulin resistance and the metabolic syndrome in a group of adolescents.BackgroundObesity is now considered a chronic low‐grade inflammatory process, characterised by alterations in the systemic concentrations of some inflammation markers. Adiponectin, leptin and other inflammatory proteins have been shown to correlate with insulin resistance and the metabolic syndrome in adults.DesignCross‐sectional study in two groups of obese and normal weight adolescents.MethodsSerum levels of adiponectin, leptin, ceruloplasmin and insulin levels were determined and correlated among them and with anthropometric parameters, blood pressure body mass index and body mass index z‐score.ResultsWaist circumference, body mass index and blood pressure values correlated significantly with both homoeostasis model assessment for insulin resistance and insulin levels. Ceruloplasmin also correlated with both parameters with a high level of significance. However, leptin levels did not correlate with either homoeostasis model assessment for insulin resistance or insulin, and adiponectin correlated with homoeostasis model assessment for insulin resistance but not insulin. All inflammation markers studied correlated with the body mass index z‐score. These correlations were stronger in the group of obese individuals compared to lean ones.ConclusionsWe found a relationship between insulin resistance and some inflammation in adolescents, which was particularly strong in obese individuals and was associated with the development of metabolic syndrome. Among the inflammation markers studied, ceruloplasmin revealed as a potential string marker of insulin resistance in obese adolescents.Relevance to clinical practiceThe results obtained in this study imply a significant advance in the field of clinical practice of nursing. The adequate understanding by nursing personnel of the inflammatory processes inherent to obesity constitutes a key factor for the prevention of the disease and its complications in adolescents.
Fibrinogen may mediate the association between long sleep duration and coronary heart disease
Authors: Hale Lauren , Parente Victoria , Dowd Jennifer Beam , Sands Megan , Berger Jeffrey S. , Song Yiqing , Martin Lisa W. , Allison Matthew A. 
Published: December 2012

SummaryLong sleep duration has been associated with increased risk of cardiovascular disease (CVD) and all‐cause mortality. Inflammation and coagulation have been hypothesized as possible physiological pathways to explain this association, although specific biomarkers have not been studied. Using longitudinal data from 3942 postmenopausal women in the Women's Health Initiative observational study and clinical trials, we investigated whether fibrinogen, an acute‐phase inflammatory protein involved in blood clotting, mediates the associations between sleep duration and coronary heart disease (CHD) and mortality among women. Fibrinogen levels were associated positively with self‐reported long sleep duration (9+ h per night), CHD and all‐cause mortality, even after adjustment for a range of sociodemographic characteristics, cardiovascular risk factors and comorbidities.Compared with self‐reported 7–8 h per night sleep duration, self‐reported long sleep duration was associated with increased odds of CHD [odds ratio (OR) = 2.05, 95% confidence interval (CI): 1.02–4.11]. Adjustment for fibrinogen levels reduced the increased odds of CHD associated with long sleep by approximately 8 percentage points (OR = 1.97, 95% CI: 0.98–3.97). A similar reduction in the OR was observed with mortality. For both outcomes there is support for partial mediation of 6–7%, suggesting that fibrinogen may be a mechanism through which long sleep duration is associated with CHD and mortality.