bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of genetic factors in patients with hepatocellular carcinoma and iron overload – a prospective series of 234 patients
Authors: Funakoshi Natalie , Chaze Iphigénie , Alary Anne‐Sophie , Tachon Gaëlle , Cunat Séverine , Giansily‐Blaizot Muriel , Bismuth Michael , Larrey Dominique , Pageaux Georges‐Philippe , Schved Jean‐François , Donnadieu‐Rigole Hélène , Blanc Pierre , Aguilar‐Martinez Patricia 
Published: October 2015

AbstractBackground & AimsIron overload (IO) in HFE‐related hereditary haemochromatosis is associated with increased risk of liver cancer. This study aimed to investigate the role of other genes involved in hereditary IO among patients with hepatocellular carcinoma (HCC).MethodsPatients with HCC diagnosed in our institution were included in this prospective study. Those with ferritin levels ≥300 μg/L (males) or ≥200 μg/L (females) and/or transferrin saturation ≥50% (males) or ≥45% (females) had liver iron concentration (LIC) evaluated by MRI. HFE C282Y and H63D mutations were screened. Genetic analyses of genes involved in hereditary IO (HFE, HJV/HFE2, HAMP, TFR2, SLC40A1, GNPAT) were performed in patients with increased LIC.ResultsA total of 234 patients were included; 215 (92%) had common acquired risk factors of HCC (mainly alcoholism or chronic viral hepatitis). 119 patients had abnormal iron parameters. Twelve (5.1%) were C282Y homozygotes, three were compound C282Y/H63D heterozygotes. LIC was measured by MRI in 100 patients. Thirteen patients with a LIC>70 μmol/g were enrolled in further genetic analyses: two unrelated patients bore the HAMP:c.‐153C>T mutation at the heterozygous state, which is associated with increased risk of IO and severe haemochromatosis. Specific haplotypes of SLC40A1 were also studied.ConclusionsAdditional genetic risk factors of IO were found in 18 patients (7.7%) among a large series of 234 HCC patients. Screening for IO and the associated at‐risk genotypes in patients who have developed HCC, is useful for both determining etiologic diagnosis and enabling family screening and possibly primary prevention in relatives.
MULTILEVEL POLICY ENFORCEMENT: INNOVATIONS IN HOW TO ADMINISTER LIBERALIZED GLOBAL MARKETS
Authors: HEIDBREDER EVA G. 
Published: October 2015

AbstractMultilevel governance that spans beyond traditional hierarchical steering within states creates new policy enforcement challenges because it involves autonomous administrations of different jurisdictions in a single administrative act. Scrutinizing concrete new coordination tools, the article aims at conceptualizing coordination strategies and instruments to overcome structural problems in multilevel policy execution and trans‐boundary administration. The empirical findings on instrument innovation in the European Union highlight the increased strategic promotion of horizontal administrative coordination. The functioning logic and autonomy‐preserving character of such vertical coordination makes it a potential solution to functionally equivalent enforcement challenges on the global scale, exemplified by the administrative implementation of international trade agreements.
Genomic selection in biparental populations: assessment of parameters for optimum estimation set design
Authors: Marulanda Jose J. , Melchinger Albrecht E. , Würschum Tobias 
Published: October 2015

AbstractThe prediction accuracy in genomic selection is affected by complex interactions of molecular, genetic and phenotypic factors. Despite the extensive use of biparental populations for empirical‐ and simulation‐based studies, the highly variable prediction accuracies produced by cross‐validation have not been further investigated. Understanding factors correlated with the variability in prediction accuracy could provide new insights for estimation set (ES) design. In this study, we employed simulations and show that parameters derived from marker data are not associated with prediction accuracy within biparental populations and, therefore, cannot serve as tool for optimum ES design. In contrast, the phenotypic variance in the ES is a major factor correlated with prediction accuracy. In particular, for estimation sets of small size, a large phenotypic variance probably ensures that more quantitative trait loci are segregating in the ES which consequently allows a better marker effect estimation. While the ES phenotypic variance is not known beforehand, we discuss approaches how prediction accuracy could nevertheless be maximized for small estimation sets, towards a more efficient implementation of genomic selection within biparental families in plant breeding.
N1 and P2 to words and wordlike stimuli in late elementary school children and adults
Authors: Coch Donna , Meade Gabriela 
Published: October 2015

AbstractIn an investigation of the development of fine‐tuning for word processing across the late elementary school years as indexed by the posterior N1 and P2 components of the ERP waveform, third, fourth, and fifth graders and a comparison group of adults viewed words, pseudowords, nonpronounceable letter strings, and false font strings in a semantic categorization task. In adults, N1 was larger to and P2 was later to words as compared to pseudowords, a finely tuned effect of lexicality reflecting specialization for word processing. In contrast, in each group of children, N1 was larger to letter strings than false font strings and P2 was larger to false font strings than letter strings, reflecting coarse encoding for orthography. In regression analyses, scores on standardized behavioral test measures of orthographic knowledge, decoding skill, and fluency predicted N1 amplitude; these effects were not significant with age included as a separate predictor. None of the behavioral scores, in models including or not including age, predicted P2 amplitude. In direct comparisons between groups, there were multiple differences between the child and adult groups for both N1 and P2 amplitude effects, and only a single significant difference between two child groups. Overall, the findings suggest a lengthy developmental time course for the fine‐tuning of early word processing as indexed by N1 and P2.
A Three‐factor Structure of Emotion Understanding in Third‐grade Children
Authors: Castro Vanessa L. , Halberstadt Amy G. , Garrett‐Peters Patricia 
Published: October 2015

AbstractTheoretical conceptualizations of emotion understanding generally imply a two‐factor structure comprised of recognition of emotional expressions and understanding emotion‐eliciting situations. We tested this structure in middle childhood and then explored the unique predictive value of various facets of emotion understanding in explaining children's socioemotional competence. Participants were 201 third‐grade children and their mothers. Children completed five different measures, which provided eight distinct indices of emotion understanding. Mothers completed two questionnaires assessing children's socioemotional skills and problems. Results indicated that: (a) emotion understanding in third‐grade children was differentiated into three unique factors: Prototypical Emotion Recognition, Prototypical Emotion Knowledge, and Advanced Emotion Understanding, (b) skills within factors were modestly related, (c) factors varied in complexity, supporting theoretical and empirical models detailing developmental sequencing of skills, and (d) skills in Prototypical Emotion Knowledge were uniquely related to mothers’ reports of third‐grade children's socioemotional competence. Implications regarding elementary‐school‐age children's social cognitive development are discussed.
New Carboniferous fossils of Spilapteridae enlighten postembryonic wing development in Palaeodictyoptera
Authors: PROKOP JAKUB , NEL ANDRÉ , ENGEL MICHAEL S. , PECHAROVÁ MARTINA , HÖRNSCHEMEYER THOMAS 
Published: October 2015

AbstractA new palaeodictyopterid nymphBizarrea obscuragen.n.etsp.n.(Spilapteridae) and a new adult specimen ofHomaloneuracf.dabasinskasiCarpenter are described from thePennsylvanian (Moscovian) ironstone nodules ofMazonCreek (IL,U.S.A.). Both taxa share enlarged prothoracic lobes (interpreted by some as winglets), heteronomous meso‐ and metathoracic wing pads or wings, a slender abdomen with pointed laterotergites, and a unique division of the abdominal segments by two transverse sulci. An alternative hypothesis for the placement ofBizarreawithinHomoiopteridae is considered on the basis of its large body size and relatively short wing pads. Based on the morphology of the new material, postembryonic development of wing pads inPalaeodictyoptera (Palaeodictyopterida) is reconsidered. Detailed investigation of the abdominal segments, including examination by scanning electron microscopy, reveals the presence of subcircular, sclerotized structures partially covered at the bases of the nymphal laterotergites I–VII, ?VIII. Based on their position and shape, these structures are interpreted as abdominal spiracles, and thus a terrestrial or semiaquatic habitat for these immatures is hypothesized. Moreover, our discovery of the same, supposedly homologous structures in the enigmaticVogesonymphidae (Permoplectoptera), from theMiddleTriassic ofGrès àVoltzia inFrance, is evidence for the parallel coexistence of ancestrally terrestrial and derived aquatic lineages ofEphemerida (Ephemeropterida) in earlyMesozoic ecosystems.This published work has been registered in ZooBank,http://zoobank.org/urn:lsid:zoobank.org:pub:A7270D99‐5B48‐4EAC‐AEB8‐EFB8A9F55FBD.
Central diabetes insipidus following cardiopulmonary arrest in a dog
Authors: Bellis Tara , Daly Meredith , Davidson Benjamin 
Published: October 2015

AbstractObjectiveTo describe a clinical case of transient central diabetes insipidus (CDI) occurring post cardiopulmonary arrest (CPA) in a dog.Case SummaryAn 8‐week‐old dog presented for intensive care after successful resuscitation following CPA. The patient exhibited neurologic deficits at initial presentation and over the following days developed marked polyuria, isosthenuria, and low urine osmolality. Treatment with synthetic vasopressin resulted in a reduction in urine output, increase in urine specific gravity (>50%), and increase in urine osmolality, suggesting a diagnosis of partial CDI. Clinical signs resolved over the following weeks and treatment was discontinued.New or Unique Information ProvidedCPA has been described as a cause of ischemic injury to the pituitary gland resulting in CDI in people. To the authors’ knowledge, this is the first report of a dog developing transient partial CDI following CPA and successful resuscitation.
Dressing with epigallocatechin gallate nanoparticles for wound regeneration
Authors: Lin Yu‐Hsin , Lin Jui‐Hsiang , Li Tzong‐Shiun , Wang Shih‐Hao , Yao Chun‐Hsu , Chung Wan‐Yu , Ko Tse‐Hao 
Published: October 2015

AbstractSeveral reagents have been studied to overcome the problems encountered with antiseptic use, such as moderate cutaneous wound cytotoxicity and skin thinning. We successfully prepared a gelatin/chitosan/epigallocatechin gallate nanoparticle incorporated in a poly(γ‐glutamic acid)/gelatin hydrogel, which comprised activated carbon fibers with gentamicin, to fabricate a sandwiched dressing to enhance wound regeneration. The inner layer of activated carbon fibers with gentamicin was designed to prevent bacterial infection, and the outer layer of gelatin/chitosan/epigallocatechin gallate nanoparticles incorporated in a poly(γ‐glutamic acid)/gelatin hydrogel was designed to prevent inflammation and facilitate reepithelialization. An in vitro study demonstrated that the dressing effectively inhibited target microorganisms, and scanning electron microscope and confocal laser scanning microscope indicated that the nanoparticles were homogeneously dispersed and migrated into the hydrogel. The in vivo study reported that the sandwiched dressing, comprising the poly(γ‐glutamic acid)/gelatin hydrogel, was easy to remove from the wound and facilitated wound tissue regeneration and accelerated healing process.
Lung deformations and radiation‐induced regional lung collapse in patients treated with stereotactic body radiation therapy
Authors: Diot Quentin , Kavanagh Brian , Vinogradskiy Yevgeniy , Garg Kavita , Gaspar Laurie , Miften Moyed 
Published: October 2015

Purpose:To differentiate radiation‐induced fibrosis from regional lung collapse outside of the high dose region in patients treated with stereotactic body radiation therapy (SBRT) for lung tumors.Methods:Lung deformation maps were computed from pre‐treatment and post‐treatment computed tomography (CT) scans using a point‐to‐point translation method. Fifty anatomical landmarks inside the lung (vessel or airway branches) were matched on planning and follow‐up scans for the computation process. Two methods using the deformation maps were developed to differentiate regional lung collapse from fibrosis: vector field and Jacobian methods. A total of 40 planning and follow‐ups CT scans were analyzed for 20 lung SBRT patients.Results:Regional lung collapse was detected in 15 patients (75%) using the vector field method, in ten patients (50%) using the Jacobian method, and in 12 patients (60%) by radiologists. In terms of sensitivity and specificity the Jacobian method performed better. Only weak correlations were observed between the dose to the proximal airways and the occurrence of regional lung collapse.Conclusions:The authors presented and evaluated two novel methods using anatomical lung deformations to investigate lung collapse and fibrosis caused by SBRT treatment. Differentiation of these distinct physiological mechanisms beyond what is usually labeled “fibrosis” is necessary for accurate modeling of lung SBRT‐induced injuries. With the help of better models, it becomes possible to expand the therapeutic benefits of SBRT to a larger population of lung patients with large or centrally located tumors that were previously considered ineligible.
Draft Genome Sequences of Acinetobacter parvus CM11, Acinetobacter radioresistens CM38, and Stenotrophomonas maltophilia BR12, Isolated from Murine Proximal Colonic Tissue
Authors: Saffarian Azadeh , Mulet Céline , Naito Tomoaki , Bouchier Christiane , Tichit Magali , Ma Laurence , Grompone Gianfranco , Sansonetti Philippe J. , Pédron Thierry 
Published: October 2015

ABSTRACT

Here, we report three genome sequences of bacteria isolated from murine proximal colonic tissue and identified as
Acinetobacter parvus
CM11,
Acinetobacter radioresistens
CM38, and
Stenotrophomonas maltophilia
BR12.
Genome Sequences of Poaceae-Associated Gemycircularviruses from the Pacific Ocean Island of Tonga
Authors: Male Maketalena F. , Kami Viliami , Kraberger Simona , Varsani Arvind 
Published: October 2015

ABSTRACT

We sampled and analyzed 43 Poaceae plants from the Pacific Ocean island of Tonga for the presence of circular DNA viruses. From these samples, we recovered three gemycircularvirus genomes, which share >99% identity, from
Brachiaria deflexa
(
n
= 2) and sugarcane (
n
= 1). These genomes share <61% genome-wide identity with other gemycircularvirus sequences in public databases.
Genome Sequence of a Urease-Positive Campylobacter lari Strain
Authors: Meinersmann Richard J. , Bono James L. , Lindsey Rebecca L. , Genzlinger Linda L. , Loparev Vladimir N. , Oakley Brian B. 
Published: October 2015

ABSTRACT

Campylobacter lari
is frequently isolated from shore birds and can cause illness in humans. Here, we report the draft whole-genome sequence of a urease-positive strain of
C. lari
that was isolated in estuarial water on the coast of Delaware, USA.
Draft Genome Sequence of the Animal and Human Pathogen
Malassezia pachydermatis
Strain CBS 1879
Authors: Triana Sergio , González Andrés , Ohm Robin A. , Wösten Han A. B. , de Cock Hans , Restrepo Silvia , Celis Adriana 
Published: October 2015

ABSTRACT

Malassezia pachydermatis
is a basidiomycetous yeast that causes infections in humans and animals. Here, we report the genome sequence of
Malassezia pachydermatis
strain CBS 1879, which will facilitate the study of mechanisms underlying pathogenicity of the only non-lipid-dependent
Malasezzia
species.
Complete Genome Sequence of Klebsiella variicola Strain HKUOPLA, a Cellulose-Degrading Bacterium Isolated from Giant Panda Feces
Authors: Lu Matthew Guan-Xi , Jiang Jingwei , Liu Lirui , Ma Angel Po-Yee , Leung Frederick Chi-Ching 
Published: October 2015

ABSTRACT

We report here the complete genome sequence of
Klebsiella variicola
strain HKUOPLA, isolated from a giant panda feces sample collected from Ocean Park, Hong Kong. The complete genome of this bacterium may contribute toward the discovery of efficient cellulose-degrading pathways.
Draft Genome Sequence of Salmonella enterica subsp.
enterica
Serovar Mishmarhaemek Isolated from Bovine Feces
Authors: Cooper Ashley , Lambert Dominic , Koziol Adam G. , Seyer Karine , Carrillo Catherine D. 
Published: October 2015

ABSTRACT

Salmonella enterica
subsp.
enterica
serovar Mishmarhaemek is a Gram-negative, non-spore-forming, rod-shaped bacterium implicated in human clinical disease. Here, we report a 4.8-Mbp draft genome sequence of a nalidixic acid-resistant isolate of
S.
serovar Mishmarhaemek.
Co-occurrence of developmental and behavioural problems in moderate to late preterm-born children
Authors: Potijk Marieke R , de Winter Andrea F , Bos Arend F , Kerstjens Jorien M , Reijneveld Sijmen A 
Published: October 2015

ObjectiveTo determine the occurrence of emotional and behavioural problems (EBP) in moderate to late preterm (MLP) and full-term children with developmental delay.DesignParticipants were recruited from 13 randomly selected preventive child healthcare (PCH) centres in the Netherlands. We included 903 MLP children of 32–36 weeks’ gestation and 538 full-term controls, born between January 2002 and June 2003. Parents completed the Ages and Stages Questionnaire (ASQ) and Child Behaviour Checklist (CBCL) shortly before the scheduled PCH visit at 4 years of age. Co-occurrence was defined as: ASQ total or domain score >2 SDs below the mean and a CBCL score >84th percentile on total problems, internalising (emotional) or externalising (behavioural) problems.ResultsEBP were more prevalent among MLP children with abnormal ASQ total problems scores than among full-term children, particularly regarding externalising problems (33.8% vs 23.8%). In MLP children, rates of EBP differed per developmental domain and were highest for the domains problem-solving (36.0% had externalising problems, 95% CI 24.1% to 49.9%) and personal-social skills (38.7% had internalising problems, 95% CI 26.4% to 52.8%). The risk of any type of co-occurrence was higher for MLP than for full-term children (OR 1.86; 95% CI 1.14 to 3.03). Independent risk factors for co-occurrence were male gender, low socioeconomic status and young maternal age.ConclusionsUp to 39% of 4-year-old MLP children with developmental delay also have EBP, indicating that increased awareness of EBP is warranted in MLP children with developmental delay. Further research is needed to determine whether early detection of co-occurring problems results in better long-term health.
Cost trajectories from the final life year reveal intensity of end-of-life care and can help to guide palliative care interventions
Authors: von Wyl Viktor , Telser Harry , Weber Andreas , Fischer Barbara , Beck Konstantin 
Published: October 2015

ObjectiveExploration of healthcare utilisation patterns in the final life year to assess palliative care potential.MethodsRetrospective cluster analyses (k-means) of anonymised healthcare expenditure (HCE) trajectories, derived from health insurance claims of a representative sample of Swiss decedents who died between 2008 and 2010 (2 age classes: 4818 <66 years, 22 691 elderly).Results3 (<66 years) and 5 (elderly) trajectory groups were identified, whose shapes were dominated by HCE from inpatient care in hospitals and at nursing homes. In each age class, the most expensive group (average cumulative HCE for <66 years: SFr 84 295; elderly: SFr 84 941) also had the largest abundance of cancers (<66 years: 55%; elderly: 32%) and showed signs of continued treatment intensification until shortly before death. Although sizes of these high-cost groups were comparatively small (26% in younger; 6% in elderly), they contributed substantially to the end-of-life HCE in each age class (62% and 18%, respectively).As age increased, these potential target groups for palliative care gained in share among <66-year olds (from 9% in children to 28% in 60–65-year olds), but decreased from 17% (66–70-year olds) to 1% (>90-year olds) among elderly.ConclusionsCost trajectory clustering is well suited for first-pass population screenings of groups that warrant closer inspection to improve end-of-life healthcare allocation. The Swiss data suggest that many decedents undergo intensive medical treatment until shortly before death. Investigations into the clinical circumstances and motives of patients and physicians may help to guide palliative care.
Leedsichthys problematicus
: Arthur Smith Woodward's ‘most embarrassing enigma'
Authors: Liston J. J. 
Published: October 2015

Abstract

The link between the renowned palaeoichthyologist Arthur Smith Woodward and the similarly lauded marine reptile collector Alfred Nicholson Leeds may seem an unlikely one, but they formed a close family friendship during their professional acquaintance. Amongst the many fish specimens described by Smith Woodward from Leeds’ Oxford Clay collection, the large suspension feeder
Leedsichthys problematicus
was a challenge that he failed to resolve in print. Work is done to resolve the confused storage history of the material, in order to identify and reappraise the bones that comprised the type material, in the process revealing a key misidentification that undoubtedly coloured Smith Woodward's type description, and his initial understanding and interpretation of the animal.