bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empty stomach sensation and Bothersome hunger sensation: Two Relevant Clinical Manifestations in Patients with Dyspepsia
Authors: Téllez Francisco Alejandro Félix , Troche José María Remes , Viramontes Ana Luisa Mateos , Avilés Alex René Sandoval , Álvarez Héctor Ricardo Ordaz , Velasco José Antonio Velarde Ruiz , Rendón Ángel Ricardo Flores 
Published: August 2024

Abstract

Background
Dyspepsia, characterized by symptoms in the gastroduodenal region, poses diagnostic challenges despite Rome IV criteria.
Aim
This study aimed to investigate the prevalence of two underreported symptoms, Empty Stomach Sensation and Bothersome Hunger Sensation, in dyspeptic patients, and their association with the disorder of gut-brain interaction.
Methods
A cross-sectional study surveyed 1,211 individuals in northwest Mexico, assessing dyspeptic symptoms with pictograms and a 7-point Likert scale. Logistic regression analyzed associations between dyspepsia, Empty Stomach Sensation, and Bothersome Hunger Sensation.
Results
Dyspepsia prevalence was 39.1%, being overlap syndrome the most common (42.7%) phenotypic presentation. Empty Stomach Sensation prevalence in dyspeptic patients was 43.8% versus 12.6% in non-dyspeptics (p < 0.001). Bothersome Hunger Sensation prevalence in dyspeptics was 25.4% compared to 5.6% in non-dyspeptics (p < 0.001). Both symptoms were associated with epigastric pain syndrome, postprandial distress syndrome, overlap syndrome, anxiety disorders and other gastroduodenal symptoms.
Conclusions
Empty Stomach Sensation and Bothersome Hunger Sensation, though prevalent in dyspeptic patients, are often overlooked. Strengths of this study include its large sample size and comprehensive assessment of symptoms. Limitations include the lack of diagnostic endoscopy and long-term follow-up. Future research should explore the underlying mechanisms of these symptoms and their implications for clinical management.
Primary Renal Lymphoma: A Single-Center Study of 14 Cases
Authors: Wang Tao , Zhai Hongyun , Ding Xiaohui 
Published: August 2024

Abstract

Objective
Primary renal lymphoma (PRL) is defined as a non-Hodgkin lymphoma(NHL)restricted to kidneys without extensive nodal disease. The literature on epidemiology and outcome in PRL is rare.
Methods
We re-examined the findings from cases previously diagnosed with renal lymphoma at the Department of Urology, People’s Liberation Army General Hospital, Beijing, China, between January 2009 and January 2022. Fourteen cases were identified that met the diagnostic criteria of PRL. Clinical information, including follow-up data, was collected from medical records.
Results
A total of 14 PRL patients were eligible for the study. Among these patients, there were 7 males and 7 females with an average age of 60.4 years. All cases were unilateral, with 6 cases involving the left kidney and 8 cases involving the right kidney. Eleven patients underwent radical nephrectomy, and two patients underwent partial nephrectomy, all of which were completed successfully. The subtypes included 8 cases of diffuse large B-cell lymphoma(DLBCL), 5 cases of extranodal marginal zone B-cell lymphoma༈MZBL༉, and 1 case of extranodal NK/T-cell lymphoma. Among the 14 patients, 9 received 4–6 cycles of adjuvant chemotherapy postoperatively. Four patients were treated with the R-CHOP regimen, 4 patients received the CHOP regimen, and 1 patient with extranodal NK/T-cell lymphoma was treated with COP-L combined with chidamide. As of June 2022, 7 patients were alive and 7 had died. Of the 5 patients who did not receive adjuvant chemotherapy.The progression-free survival (PFS) had a median duration of 33 (19–66) months. The overall survival (OS) had a median duration of 38 (20–72) months.
Conclusions Primary renal lymphoma is a rare lymphoma. In this
study, we desscribe demographic,clinical,and pathological
characteristics of PRL and factors affecting survival among these
patients.
DLBCL is the most common histological subtype. Nephrectomy combined with R-CHOP is recommended for treatment, with early diagnosis being crucial for improving patient outcomes.
Antibiotic Susceptibility and Risk Factors for Listeriosis in Women with Spontaneous Abortion in Ugandan Tertiary Hospitals: A cross-sectional study
Authors: Ssentongo Emmanuel , Kasujja Musa , Musinguzi Ronald , Kanika Jean Claude , Bivako Rachael , Kintu Mugagga , Byonanuwe Simon , Enyamitoit Ralph Samson , Okurut Emmanuel 
Published: August 2024

Abstract

Background
Listeriosis, caused by Listeria monocytogenes, poses significant health risks globally, particularly among pregnant women. Despite its established impact in other regions, its prevalence and antibiotic susceptibility patterns in Uganda, especially among women experiencing spontaneous abortion, remain understudied.
Objective
This cross-sectional study aimed to determine the prevalence, antibiotic susceptibility, and associated risk factors of listeriosis among women admitted with spontaneous abortion in Ugandan tertiary hospitals.
Methods
A total of 384 women from Jinja and Kayunga Regional Referral Hospitals were included. Data on socio-demographic characteristics, obstetric history, and dietary habits were collected using structured interviews and high vaginal swab cultures. Antibiotic susceptibility testing was performed, and logistic regression analysis was used to assess risk factors.
Results
The prevalence of listeriosis among participants was 11.2%. L. monocytogenes showed high susceptibility to Vancomycin (88.37%) and Clindamycin (81.40%), but significant resistance to Ampicillin (81.40%) and Amoxicillin (76.74%). Risk factors significantly associated with listeriosis included lack of formal education (adjusted odds ratio [aOR] = 7.0, 95% CI: 1.779–27.655), multiple abortions (aOR = 3.3, 95% CI: 1.486–7.427), and consumption of soft cheese, ice cream, yogurt, or ghee (aOR = 4.3, 95% CI: 1.331–14.082).
Conclusion
This study provides critical insights into the prevalence, antibiotic resistance patterns, and risk factors for listeriosis among Ugandan women with spontaneous abortion. Findings underscore the need for targeted public health interventions and antibiotic stewardship to mitigate the impact of this infection.
Prolonged Oropharyngeal Mother's Own Milk Administration to Extremely Preterm Infants: The POP-MOM Study – A Quasiexperimental Study
Authors: Guedes Flávia Magalhães , Volkmer Desirée de Freitas Valle , Scheeren Marôla Flores Cunha , Ferreira Cristina Targa , de Oliveira Mariana González 
Published: August 2024

Abstract

Background: Previous studies have assessed the safety of short-term application of oropharyngeal colostrum to preterm infants for 5-7 days. These studies revealed no differences in necrotizing enterocolitis (NEC) rates, infection, death, or feeding at discharge.
Research aims: This study aimed to investigate the association between prolonged oropharyngeal mother's own milk (POP-MOM) administration (from birth to oral transition) and the prevalence of receiving mothers’ own milk and head growth at discharge or survival without morbidities in extremely preterm (EPT < 30 weeks) infants.
Methods: The study design is quasiexperimental, with an intervention group using POP-MOM administration and a historical control group before implementing this practice. The intervention group received POP-MOM as soon as it became available and continued until the oral transition of feedings was achieved. All EPT infants admitted to the NICU without contraindications to human milk were included. The main outcome measured was receiving any volume of the mother's own milk (MOM) at discharge. The secondary outcomes assessed were insufficient head growth (head circumference < P3) at discharge and preterm-related morbidities, including severe intraventricular hemorrhage (IVH≥3), chronic lung disease (CLD), necrotizing enterocolitis (NEC), sepsis, and cystic periventricular leukomalacia (PVL).
Results: The study included 217 EPT infants, 120 patients in the control group, and 97 in the intervention group. No antenatal or clinical differences were observed between the two groups. Of the total number of infants, 189 (87.0%) survived in the NICU, and at the time of discharge, 171 (90.4%) were breastfed at least once a day. After implementing the POP-MOM protocol, there was an increased likelihood of receiving any volume of MOM at discharge in extremely preterm infants (RR=1.10, 95% CI=1.02-1.21; p=0.01). The intervention group also had lower rates of insufficient head growth (RR=0.47; 95% CI 0.23-0.98; p=.04). We did not observe complications as a result of implementing this practice.
Conclusions: Prolonged administration of the oropharyngeal mother's milk protocol was associated with an increased frequency of infants receiving any MOM volume and improved head growth at NICU discharge.
Study registration: This study is registered under the number 61359516.1.0000.5330 at the Brazilian Federal Research Registration Platform.
Establishment of an efficient pathologic diagnostic platform using core needle biopsy for salivary gland carcinoma
Authors: Kobayashi Kenya , Yoshimoto Seiichi , Omura Go , Matsumoto Yoshifumi , Sakai Azusa , Eguchi Kohtaro , Sakai Toshihiko , Honma Yoshitaka , Matsumoto Fumihiko , Kawazu Masahito , Saito Yuki , Ryo Eigitsu , Yatabe Yasushi , Moti Taisuke 
Published: August 2024

Abstract

Purpose:
A major problem in establishing treatment strategies for salivary gland cancer is the difficulty of preoperative histologic typing. In recent years, genetic evaluation has become essential for salivary gland tumor diagnosis. The core needle biopsy (CNB) allows a small piece of the center of the tumor to be taken intact and analyzed in detail. The purpose of this study was to clarify the efficacy and the limitations of CNB in the preoperative diagnosis, and to establish a generalizable preoperative histologic typing platform.
Methods: Paired preoperative 20-gauge core needle biopsy (CNB) and surgical specimens from 41 patients with malignant salivary gland tumors were reviewed. Morphological evaluation, immunohistochemical evaluation, and break-apart fluorescence in situ hybridization (FISH) assay were performed as histologic typing methods for CNB. The quality of biopsy specimens, diagnostic accuracy, and immunostaining concordance rates between biopsy and surgical specimens were analyzed.
Results: For CNB, 95% (39/41) of the specimens were of high quality, allowing adequate morphologic, immunohistologic, and genomic analysis. Two patients had unanalyzable specimens due to cystic fluid or tumor firmness. Overall, 75% (31/41) had correct preoperative histologic typing. Compared to other histologic types, carcinoma ex pleomorphic adenoma (CXPA) and salivary duct carcinoma arising from CXPA had a significantly lower concordance rate for histologic typing (50% vs. 89.6%, p=0.016) and poorer HER2 immunostaining concordance rates between CNB and surgical specimens (60% vs. 0%, p=0.001). There were no recurrences due to tumor seeding after CNB.
Conclusions: Detailed analysis of CNB specimens allows for highly accurate determination of salivary gland carcinoma histologic type with molecular diagnosis. However, careful histologic typing is necessary in pathologically heterogeneous tumors.
Characterizing Gene Therapy Medicinal Products Post-Marketing Safety Reports based on WHO Pharmacovigilance Database, VigiBase
Authors: Lim Min-Jung , Paek Eunah , Shin Ju-Young 
Published: August 2024

Abstract

Background Safety assessments of gene therapy medicinal products (GTMPs) require comprehensive data collection from a variety of sources to ensure thorough evaluation. This study aimed to analyze the characteristics of adverse event (AE) reports for GTMPs, dividing them into Solicited Reports (SRs) and Unsolicited Reports (USRs), and to provide insights for developing effective pharmacovigilance strategies customized for GTMPs.Methods Individual case safety reports (ICSRs) collected from GTMPs were retrieved using VigiBase. We identified GTMPs approved by the United States Food and Drug Administration (US FDA) and/or European Medicines Agency (EMA) by December 31, 2022, and maintained their approval status as of July 28, 2023. Descriptive statistics were used to summarize the ICSRs’ characteristics. The reported AEs were classified into System Organ Classes (SOCs) and Preferred Terms (PTs).Results A total of 12,180 ICSRs for 13 GTMPs were retrieved from VigiBase. Of these, 27.6% were SR and 72.4% USR. As the number of ICSRs increased, the proportion of USR tended to increase. Compared to the SR, consumer reports were much less common in the USR. The majority of the reported events were serious in both groups. In the drug-AE pairs, cytokine release syndrome and pyrexia were the most commonly reported in both the SR and USR. Meanwhile the most frequently reported SOCs were “Investigations” in SR and “Nervous system disorders” in USR, respectively.Conclusions Our study highlights the need for robust pharmacovigilance measures customized for GTMPs. The continued refinement of pharmacovigilance strategies customized for GTMPs is essential to ensure their safe and effective use.
Potential links between intense volcanism and the late-Archean “whiff” of oxygen
Authors: Watanabe Yasuto , Ozaki Kazumi , Harada Mariko , Matsumoto Hironao , Tajika Eiichi 
Published: August 2024

Abstract

The Archean Earth was characterized by a persistent weakly reducing atmosphere, while accumulated geological records suggest occurrence of transient atmospheric oxygenation events—whiff of oxygen—during the late Archean, the precise nature and causes of which remain elusive. We used a biogeochemical model to propose the eruption of large igneous provinces (LIPs) as a plausible mechanistic explanation for the transient oxygenation events in the late Archean atmosphere. Here we show that biogeochemical dynamics induced by LIP eruptions could have caused transient increase in the level of atmospheric oxygen (O2) for more than several million years. Notably, continental growth during the late Archean would have mitigated the conditions for transient oxygenation, suggesting that the late Archean Earth system approached a tipping point for permanent oxidation of the atmosphere. The late Archean atmosphere might have evolved dynamically through interactions with the ocean and the biosphere, modified by LIP eruptions.
Validity and Reliability of the Turkish Version of the Salzburg Emotional Eating Scale: A Psychometric Study
Authors: Gültekin Ayşenur , Bozkır Çiğdem 
Published: August 2024

Abstract

Background: The Salzburg Emotional Eating Scale (SEES) measures emotional eating by evaluating responses to both positive and negative emotions. This study aimed to establish the validity and reliability of the Turkish version of the SEES (SEES-TR).
Method: The SEES was translated into Turkish and back-translated into English. The translated version was reviewed by experts and pretested on a preliminary sample. The final version was administered to 303 participants from Namık Kemal University. The data collected included demographic information and responses to the SEES and the Emotional Eating subscale of the Dutch Eating Behavior Questionnaire (DEBQ). Reliability was assessed using Cronbach's alpha, McDonald's omega, and test-retest analyses. Validity was evaluated using exploratory and confirmatory factor analyses, along with content and surface validity.
Results: The SEES-TR demonstrated high internal consistency, with Cronbach's alpha values of 0.924 for the total scale and above 0.90 for the subscales. McDonald's omega values supported these findings. Test-retest reliability indicated stability over time. Exploratory factor analysis confirmed a four-factor structure corresponding to happiness, sadness, anger, and anxiety, which was further supported by confirmatory factor analysis. Content and surface validity were established through expert reviews and pretesting.
Conclusion: The Turkish version of the Salzburg Emotional Eating Scale is a valid and reliable instrument for assessing emotional eating behaviors in the Turkish population. This tool can be effectively used in both clinical and research settings to evaluate emotional eating in response to various emotional states.
Identification and validation of novel characteristic genes based on multi-tissue osteoarthritis
Authors: Zheng guihao , Ouyang yulong , Chen shuilin , Hu bei , Xu shuai , Sun guicai 
Published: August 2024

Abstract

Background Osteoarthritis (OA) is characterized by synovial inflammation, articular cartilage degradation, and subchondral bone changes. Currently, there are no reliable biomarkers for the diagnosis and treatment of OA. Therefore, exploring OA biomarkers is crucial for its prevention, diagnosis, and treatment.Materials and Methods The GSE51588, GSE12021, GSE55457, GSE56409, GSE114007, GSE168505, GSE169077, GSE55235, GSE129147, and GSE48556 datasets of patients with OA and normal control samples were obtained from the GEO database. Differentially expressed genes (DEGs) in OA and normal controls were identified using R language. Protein-protein interaction (PPI) network and module analysis were performed to screen and filter key genes. Enrichment analyses were conducted to determine the biological functions and pathways of key DEGs and predict potential transcription factors. Machine learning models (XGBoost, LASSO regression, and SVM) were used to identify the best characteristic genes, and the intersection of hub genes was used as the final diagnostic genes. ROC analysis and nomogram were used to evaluate the diagnostic value of candidate genes. The expression levels of characteristic genes were validated in external GEO datasets containing cartilage, synovial membrane, and blood samples from patients. The expression levels of the key gene IRS2 in chondrocytes were further confirmed through in vitro experiments.Results Fifteen OA characteristic genes (IRS2, ADM, SIK1, PTN, CX3CR1, WNT5A, IL21R, APOD, CRLF1, FKBP5, PNMAL1, NPR3, RARRES1, ASPN, POSTN) were identified using three machine learning algorithms. Enrichment analysis indicated that abnormal expression of DEGs and hub genes may be mediated by extracellular matrix organization, extracellular structure organization, Relaxin signaling pathway, IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, and PI3K-Akt signaling pathway, which are involved in OA occurrence. Four diagnostic genes (IRS2, WNT5A, PTN, POSTN) were highly correlated with OA. Validation data set analysis showed that IRS2 was down-regulated, while WNT5A, PTN, and POSTN were up-regulated in the experimental group compared to the normal group. qRT-PCR and WB results verified that the expression level of diagnostic gene IRS2 was consistent with bioinformatics analysis results.Conclusion This study integrates bioinformatics analysis and machine learning algorithms to identify and validate four promising biomarkers: IRS2, WNT5A, PTN, and POSTN. POSTN can be used as a biomarker for OA cartilage, and early diagnosis of PTN in OA deserves attention. WNT5A and IRS2 offer new diagnostic perspectives for OA.
Modified-liquid-liquid phase separation: A novel technique to synthesize 2-dimensional CuO nanosheets
Authors: Mahajan Abha , Saroja Ajay Piriya Vijaya Kumar , Sundara Ramaprabhu , Nagar Rupali 
Published: August 2024

Abstract

The 2-dimensional materials are seeing an upsurge in research and various applications. In this work, the growth of cupric oxide (CuO) nanostructures in different morphologies is reported by employing modified-liquid-liquid phase separation (m-LLPS) technique. Here, two binary phases copper sulphate-polyethylene glycol (PEG) i.e. C&P and sodium hydroxide-PEG i.e. N&P are used in tandem and reduction of copper salt is employed. Sheet-like agglomerated growth could be restrained into nice flattened disks by merely modifying the interaction of binary phases in time. X-ray diffraction (XRD) for structural information, UV-Visible spectroscopy for optical bandgap estimation, micro-Raman spectroscopy for vibrational levels investigation, and Fourier Transform Infrared spectroscopy (FTIR) as fingerprint for bond/ compound formation have been employed. The flat-disk CuO sample was used for detection of glucose. Limit of detection and limit of quantification levels were estimated and were found to be 4 mM and 13 mM, respectively. The mechanism of the modified-LLPS method leading to oriented growth from disoriented growth is discussed. By taking CuO as an example, a very simple concept of phase separation has been demonstrated to prepare 2-dimensional materials.
Efficacy of artificial intelligence preoperative planning for two patients who underwent bilateral hip joint replacement via anterior or posterior approaches for the same disease respectively
Authors: Zhu Jiaqing , Xia Tianwei , Hu Haibo , Shen Jirong 
Published: August 2024

Abstract

Objective
To summarize the diagnostic and treatment experiences of two patients who underwent bilateral hip joint replacement via anterior or posterior approaches for the same disease
Methods
Between August 2021 and April 2023, two patients with bilateral hip comorbidities were admitted. The ages of the patients were 58 and 46 years, the Harris scores were 31.3 and 34.0 on the anterior hip replacement side and 32.5 and 33.3 on the posterior hip replacement side, respectively, and the visual analog scale (Vas) was 5 on both sides. Anterior and posterior approach arthroplasties were performed on both sides of the patient's hip joints
Results
The patients' postoperative incisions healed well, with Harris scores of 45.5 and 53.0 on the anterior approach hip replacement side and 50.0 and 44.5 on the posterior approach hip replacement side at 1 week after surgery. At 3 months after surgery, the Harris scores on the side of anterior approach hip replacement were 95.0 and 91.0, respectively and the Harris scores on the side of posterior approach hip replacement were 90.5 and 83.5, respectively. The Vas score was 0 at 3 months after surgery, and no complications such as lower extremity venous thrombosis, dislocation, or infection occurred in either patient
Conclusion
For patients who undergo bilateral hip joint replacement surgery, anterior and posterior approaches can be adopted flexibly according to patient needs
Genome-wide identification and expression profiling analysis of the SPX gene family in Setaria italica
Authors: Meng Chaomin , Guo Haojie , Wang Cheng , Yang Furong , Du Bing 
Published: August 2024

Abstract

Background
In plant adaptation to adversity, phosphorus is pivotal and exerts a beneficial influence on both yield and quality formation in foxtail millet. Proteins containing SPX domains are essential for the maintenance of phosphate ion (Pi) balance in plants. However, the mechanisms that control phosphorus deficiency in foxtail millet are not yet fully understood.
Results
Through genome-wide analysis, we identified 15 members of the millet SPX gene family, which were categorized into four subfamilies (SPX, SPX-MFS, SPX-EXS, and SPX-RING) according to their structural characteristics. The genes encoding proteins with SPX domains were found on six out of the 9 chromosomes. Enrichment for multiple biotic and abiotic stresses, as well as hormone responses, was observed in the promoter regions of SiSPXs. Analysis of transcriptome data (RNA-seq) revealed diverse expression patterns among 15 genes encoding SPX-domain-containing proteins. Under low phosphate (Pi) stress, specific members, such as SiSPX3, and SiSPX9, showed a pronounced response.
Conclusions
The SPX gene primarily regulates phosphorus homeostasis and transport in foxtail millet by binding to the signal molecule InsP8.This study enhanced the comprehension of the millet SPX gene family, thereby advancing future biological investigations of SiSPX genes in millet. Additionally, it offers a selection of potential candidate genes for functional research on phosphate ion (Pi) nutrition in millet.