bluuebunny/crossref_metadata_2025_split huggingface dataset:
The development and validation of a questionnaire for rotator cuff disorders: The Functional Shoulder Score
Authors: Iossifidis Anestis , Ibrahim Edward F , Petrou Charalambos , Galanos Antonis 
Published: March 2015

Background The purpose of the present study was to validate the Functional Shoulder Score (FSS), a new patient-reported outcome score specifically designed to evaluate patients with rotator cuff disorders. Methods One hundred and nineteen patients were assessed using two shoulder scoring systems [the FSS and the Constant–Murley Score (CMS)] at 3 weeks pre- and 6 months post-arthroscopic rotator cuff surgery. The reliability, validity, responsiveness and interpretability of the FSS were evaluated. Results Reliability analysis (test–retest) showed an intraclass correlation coefficient value of 0.96 [95% confidence interval (CI) = 0.92 to 0.98]. Internal consistency analysis revealed a Cronbach's alpha coefficient of 0.93. The Pearson correlation coefficient FSS-CMS was 0.782 pre-operatively and 0.737 postoperatively ( p < 0.0005). There was a statistically significant increase in FSS scores postoperatively, an effect size of 3.06 and standardized response mean of 2.80. The value for minimal detectable change was ±8.38 scale points (based on a 90% CI) and the minimal clinically important difference for improvement was 24.7 ± 5.4 points. Conclusions The FSS is a patient-reported outcome measure that can easily be incorporated into clinical practice, providing a quick, reliable, valid and practical measure for rotator cuff problems. The questionnaire is highly sensitive to clinical change.
The research capacity and culture of Australian podiatrists
Authors: Williams Cylie M , Lazzarini Peter A 
Published: March 2015

AbstractBackgroundBest practice clinical health care is widely recognised to be founded on evidence based practice. Enhancing evidence based practice via the rapid translation of new evidence into every day clinical practice is fundamental to the success of health care and in turn health care professions. There is little known about the collective research capacity and culture of the podiatry profession across Australia. Thus, the aim of this study was to investigate the research capacity and culture of the podiatry profession within Australia and determine if there were any differences between podiatrists working in different health sectors and workplaces.MethodAll registered podiatrists were eligible to participate in a cross‐sectional online survey. The Australian Podiatry Associations disseminated the survey and all podiatrists were encouraged to distribute it to colleagues. The Research Capacity and Culture (RCC) tool was used to collect all research capacity and culture item variables using a 10‐point scale (1 = lowest; 10 = highest). Additional demographic, workplace and health sector data variables were also collected. Mann–Whitney‐U, Kruskal–Wallis and logistic regression analyses were used to determine any difference between health sectors and workplaces. Word cloud analysis was used for qualitative responses of individual motivators and barriers to research culture.ResultsThere were 232 fully completed surveys (6% of Australian registered podiatrists). Overall respondents reported low success or skills (Median rating < 4) on the majority of individual success or skill items. Podiatrists working in multi‐practitioner workplaces reported higher individual success or skills in the majority of items compared with sole practitioners (p < 0.05). Non‐clinical and public health sector podiatrists reported significantly higher post‐graduate study enrolment or completion, research activity participation, provisions to undertake research and individual success or skill than those working privately.ConclusionsThis study suggests that podiatrists in Australia report similar low levels of research success or skill to those reported in other allied health professions. The workplace setting and health sector seem to play key roles in self reported research success and skills. This is important knowledge for podiatrists and researchers aiming to translate research evidence into clinical practice.
Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients
Authors: Kalfon Pierre , Le Manach Yannick , Ichai Carole , Bréchot Nicolas , Cinotti Raphaël , Dequin Pierre-François , Riu-Poulenc Béatrice , Montravers Philippe , Annane Djilalli , Dupont Hervé , Sorine Michel , Riou Bruno ,   on behalf of the CGAO-REA Study Group
Published: March 2015

Abstract
Introduction
In a randomized controlled trial comparing tight glucose control with a computerized decision support system and conventional protocols (post hoc analysis), we tested the hypothesis that hypoglycemia is associated with a poor outcome, even when controlling for initial severity.

Methods
We looked for moderate (2.2 to 3.3 mmol/L) and severe (<2.2 mmol/L) hypoglycemia, multiple hypoglycemic events (n ≥3) and the other main components of glycemic control (mean blood glucose level and blood glucose coefficient of variation (CV)). The primary endpoint was 90-day mortality. We used both a multivariable analysis taking into account only variables observed at admission and a multivariable matching process (greedy matching algorithm; caliper width of 10−5 digit with no replacement).

Results
A total of 2,601 patients were analyzed and divided into three groups: no hypoglycemia (n =1,474), moderate hypoglycemia (n =874, 34%) and severe hypoglycemia (n =253, 10%). Patients with moderate or severe hypoglycemia had a poorer prognosis, as shown by a higher mortality rate (36% and 54%, respectively, vs. 28%) and decreased number of treatment-free days. In the multivariable analysis, severe (odds ratio (OR), 1.50; 95% CI, 1.36 to 1.56; P =0.043) and multiple hypoglycemic events (OR, 1.76, 95% CI, 1.31 to 3.37; P <0.001) were significantly associated with mortality, whereas blood glucose CV was not. Using multivariable matching, patients with severe (53% vs. 35%; P <0.001), moderate (33% vs. 27%; P =0.029) and multiple hypoglycemic events (46% vs. 32%, P <0.001) had a higher 90-day mortality.

Conclusion
In a large cohort of ICU patients, severe hypoglycemia and multiple hypoglycemic events were associated with increased 90-day mortality.

Trial registration
Clinicaltrials.gov Identifier: NCT01002482. Registered 26 October 2009.
Systolic blood pressure and short-term mortality in the emergency department and prehospital setting: a hospital-based cohort study
Authors: Kristensen Anders Kasper Bruun , Holler Jon Gitz , Mikkelsen Søren , Hallas Jesper , Lassen Annmarie 
Published: March 2015

Abstract
Introduction
Systolic blood pressure is a widely used tool to assess circulatory function in acutely ill patients. The systolic blood pressure limit where a given patient should be considered hypotensive is the subject of debate and recent studies have advocated higher systolic blood pressure thresholds than the traditional 90 mmHg. The aim of this study was to identify the best performing systolic blood pressure thresholds with regards to predicting 7-day mortality and to evaluate the applicability of these in the emergency department as well as in the prehospital setting.

Methods
A retrospective, hospital-based cohort study was performed at Odense University Hospital that included all adult patients in the emergency department between 1995 and 2011, all patients transported to the emergency department in ambulances in the period 2012 to 2013, and all patients serviced by the physician-staffed mobile emergency care unit (MECU) in Odense between 2007 and 2013. We used the first recorded systolic blood pressure and the main outcome was 7-day mortality. Best performing thresholds were identified with methods based on receiver operating characteristics (ROC) and multivariate regression. The performance of systolic blood pressure thresholds was evaluated with standard summary statistics for diagnostic tests.

Results
Seven-day mortality rates varied from 1.8 % (95 % CI (1.7, 1.9)) of 112,727 patients in the emergency department to 2.2 % (95 % CI (2.0, 2.5)) of 15,862 patients in the ambulance and 5.7 % (95 % CI (5.3, 6.2)) of 12,270 patients in the mobile emergency care units. Best performing thresholds ranged from 95 to 119 mmHg in the emergency department, 103 to 120 mmHg in the ambulance, and 101 to 115 mmHg in the MECU but area under the ROC curve indicated poor overall discriminatory performance of SBP thresholds in all cohorts.

Conclusions
Systolic blood pressure alone is not sufficient to identify patients at risk regardless of the defined threshold for hypotension. If, however, a threshold is to be defined, a systolic blood pressure threshold of 100 to 110 mmHg is probably more relevant than the traditional 90 mmHg.
Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy
Authors: Snyder Kimberly A , Hughes Michael R , Hedberg Bradley , Brandon Jill , Hernaez Diana Canals , Bergqvist Peter , Cruz Frederic , Po Kelvin , Graves Marcia L , Turvey Michelle E , Nielsen Julie S , Wilkins John A , McColl Shaun R , Babcook John S , Roskelley Calvin D , McNagny Kelly M 
Published: March 2015

Abstract
Introduction
Podocalyxin (gene name PODXL) is a CD34-related sialomucin implicated in the regulation of cell adhesion, migration and polarity. Upregulated expression of podocalyxin is linked to poor patient survival in epithelial cancers. However, it is not known if podocalyxin has a functional role in tumor progression.

Methods
We silenced podocalyxin expression in the aggressive basal-like human (MDA-MB-231) and mouse (4T1) breast cancer cell lines and also overexpressed podocalyxin in the more benign human breast cancer cell line, MCF7. We evaluated how podocalyxin affects tumorsphere formation in vitro and compared the ability of podocalyxin-deficient and podocalyxin-replete cell lines to form tumors and metastasize using xenogenic or syngeneic transplant models in mice. Finally, in an effort to develop therapeutic treatments for systemic cancers, we generated a series of antihuman podocalyxin antibodies and screened these for their ability to inhibit tumor progression in xenografted mice.

Results
Although deletion of podocalyxin does not alter gross cell morphology and growth under standard (adherent) culture conditions, expression of PODXL is required for efficient formation of tumorspheres in vitro. Correspondingly, silencing podocalyxin resulted in attenuated primary tumor growth and invasiveness in mice and severely impaired the formation of distant metastases. Likewise, in competitive tumor engraftment assays where we injected a 50:50 mixture of control and shPODXL (short-hairpin RNA targeting PODXL)-expressing cells, we found that podocalyxin-deficient cells exhibited a striking decrease in the ability to form clonal tumors in the lung, liver and bone marrow. Finally, to validate podocalyxin as a viable target for immunotherapy, we screened a series of novel antihuman podocalyxin antibodies for their ability to inhibit tumor progression in vivo. One of these antibodies, PODOC1, potently blocked tumor growth and metastasis.

Conclusions
We show that podocalyxin plays a key role in the formation of primary tumors and distant tumor metastasis. In addition, we validate podocalyxin as potential target for monoclonal antibody therapy to inhibit primary tumor growth and systemic dissemination.
HIV effects on age-associated neurocognitive dysfunction: premature cognitive aging or neurodegenerative disease?
Authors: Cohen Ronald A , Seider Talia R , Navia Bradford 
Published: March 2015

AbstractMarked improvements in survival and health outcome for people infected with HIV have occurred since the advent of combination antiretroviral therapy over a decade ago. Yet HIV-associated neurocognitive disorders continue to occur with an alarming prevalence. This may reflect the fact that infected people are now living longer with chronic infection. There is mounting evidence that HIV exacerbates age-associated cognitive decline. Many middle-aged HIV-infected people are experiencing cognitive decline similar that to that found among much older adults. An increased prevalence of vascular and metabolic comorbidities has also been observed and is greatest among older adults with HIV. Premature age-associated neurocognitive decline appears to be related to structural and functional brain changes on neuroimaging, and of particular concern is the fact that pathology indicative of neurodegenerative disease has been shown to occur in the brains of HIV-infected people. Yet notable differences also exist between the clinical presentation and brain disturbances occurring with HIV and those occurring in neurodegenerative conditions such as Alzheimer’s disease. HIV interacts with the aging brain to affect neurological structure and function. However, whether this interaction directly affects neurodegenerative processes, accelerates normal cognitive aging, or contributes to a worsening of other comorbidities that affect the brain in older adults remains an open question. Evidence for and against each of these possibilities is reviewed.
Fixed point and common fixed point results in cone metric space and application to invariant approximation
Authors: Kumar Anil , Rathee Savita 
Published: March 2015

AbstractIn this work, the concept of almost contraction for multi-valued mappings in the setting of cone metric spaces is defined and then we establish some fixed point and common fixed point results in the set-up of cone metric spaces. As an application, some invariant approximation results are obtained. The results of this paper extend and improve the corresponding results of multi-valued mapping from metric space theory to cone metric spaces. Further our results improve the recent result of Arshad and Ahmad (Sci. World J. 2013:481601, 2013).
The medial circumflex femoral artery origin variability and its radiological and surgical intervention significance
Authors: Al-Talalwah Waseem 
Published: March 2015

AbstractThe medial circumflex femoral artery usually arises from the deep femoral artery. It supplies the supplies adductors and hamstring group as well as sciatic nerve and femoral head and neck through anastomosis. In current study includes 342 dissected hemipelvis to clarify the origin of medial circumflex femoral artery. The medial circumflex femoral artery arose from the common and deep femoral artery in 39.3% and 57%. Infrequently, it arose from the superficial femoral artery in 2.5% whereas it arose from the lateral circumflex femoral artery in 0.6%. In contrast, it found to be congenital absent in 0.6%. In current study, the usual origin level of medial circumflex femoral artery found to be proximal to lateral circumflex femoral artery in 52% and distal to the deep femoral artery in 57.3%. Knowing the medial circumflex femoral artery limits avascular necrosis of the femoral head such as embolization procedure. Therefore, knowing the origin variability of the medial circumflex femoral artery may lead to avoid iatrogenic fault in several procedures such as arterial bypass procedure to protect vascular supply of lower limb. Radiologists as well as orthopedics and vascular surgeons have to be aware of the medial circumflex femoral artery variation.
The numerical frontier of the high-redshift Universe
Authors: Greif Thomas H 
Published: March 2015

AbstractThe first stars are believed to have formed a few hundred million years after the big bang in so-called dark matter minihalos with masses $\sim 10^{6}\mbox{ M}_{\odot}$
∼

10

6

M
⊙

. Their radiation lit up the Universe for the first time, and the supernova explosions that ended their brief lives enriched the intergalactic medium with the first heavy elements. Influenced by their feedback, the first galaxies assembled in halos with masses $\sim10^{8}\mbox{ M}_{\odot}$
∼

10

8

M
⊙

, and hosted the first metal-enriched stellar populations. In this review, I summarize the theoretical progress made in the field of high-redshift star and galaxy formation since the turn of the millennium, with an emphasis on numerical simulations. These have become the method of choice to understand the multi-scale, multi-physics problem posed by structure formation in the early Universe. In the first part of the review, I focus on the formation of the first stars in minihalos - in particular the post-collapse phase, where disk fragmentation, protostellar evolution, and radiative feedback become important. I also discuss the influence of additional physical processes, such as magnetic fields and streaming velocities. In the second part of the review, I summarize the various feedback mechanisms exerted by the first stars, followed by a discussion of the first galaxies and the various physical processes that operate in them.
Human tendon adaptation in response to mechanical loading: a systematic review and meta-analysis of exercise intervention studies on healthy adults
Authors: Bohm Sebastian , Mersmann Falk , Arampatzis Adamantios 
Published: March 2015

Abstract

Background
The present article systematically reviews recent literature on the in vivo adaptation of asymptomatic human tendons following increased chronic mechanical loading, and meta-analyzes the loading conditions, intervention outcomes, as well as methodological aspects.

Methods
The search was performed in the databases PubMed, Web of Knowledge, and Scopus as well as in the reference lists of the eligible articles. A study was included if it conducted (a) a longitudinal exercise intervention (≥8 weeks) on (b) healthy humans (18 to 50 years), (c) investigating the effects on mechanical (i.e., stiffness), material (i.e., Young’s modulus) and/or morphological properties (i.e., cross-sectional area (CSA)) of tendons in vivo, and was reported (d) in English language. Weighted average effect sizes (SMD, random-effects) and heterogeneity (Q and I

2
statistics) of the intervention-induced changes of tendon stiffness, Young’s modulus, and CSA were calculated. A subgroup analysis was conducted regarding the applied loading intensity, muscle contraction type, and intervention duration. Further, the methodological study quality and the risk of bias were assessed.

Results
The review process yielded 27 studies with 37 separate interventions on either the Achilles or patellar tendon (264 participants). SMD was 0.70 (confidence interval: 0.51, 0.88) for tendon stiffness (N=37), 0.69 (0.36, 1.03) for Young’s modulus (N=17), and 0.24 (0.07, 0.42) for CSA (N=33), with significant overall intervention effects (p<0.05). The heterogeneity analysis (stiffness: I

2
=30%; Young’s modulus: I

2
=57%; CSA: I

2
=21%) indicated that differences in the loading conditions may affect the adaptive responses. The subgroup analysis confirmed that stiffness adaptation significantly (p<0.05) depends on loading intensity (I

2
=0%), but not on muscle contraction type. Although not significantly different, SMD was higher for interventions with longer duration (≥12 weeks). The average score of 71±9% in methodological quality assessment indicated an appropriate quality of most studies.

Conclusions
The present meta-analysis provides elaborate statistical evidence that tendons are highly responsive to diverse loading regimens. However, the data strongly suggests that loading magnitude in particular plays a key role for tendon adaptation in contrast to muscle contraction type. Furthermore, intervention-induced changes in tendon stiffness seem to be more attributed to adaptations of the material rather than morphological properties.
Effects of rotational acetabular osteotomy on the mechanical stress within the hip joint in patients with developmental dysplasia of the hip
Authors: Ike H. , Inaba Y. , Kobayashi N. , Yukizawa Y. , Hirata Y. , Tomioka M. , Saito T. 
Published: March 2015

In this study we used subject-specific finite element analysis to investigate the mechanical effects of rotational acetabular osteotomy (RAO) on the hip joint and analysed the correlation between various radiological measurements and mechanical stress in the hip joint. We evaluated 13 hips in 12 patients (two men and ten women, mean age at surgery 32.0 years; 19 to 46) with developmental dysplasia of the hip (DDH) who were treated by RAO. Subject-specific finite element models were constructed from CT data. The centre–edge (CE) angle, acetabular head index (AHI), acetabular angle and acetabular roof angle (ARA) were measured on anteroposterior pelvic radiographs taken before and after RAO. The relationship between equivalent stress in the hip joint and radiological measurements was analysed. The equivalent stress in the acetabulum decreased from 4.1 MPa (2.7 to 6.5) pre-operatively to 2.8 MPa (1.8 to 3.6) post-operatively (p < 0.01). There was a moderate correlation between equivalent stress in the acetabulum and the radiological measurements: CE angle (R = –0.645, p < 0.01); AHI (R = –0.603, p < 0.01); acetabular angle (R = 0.484, p = 0.02); and ARA (R = 0.572, p < 0.01). The equivalent stress in the acetabulum of patients with DDH decreased after RAO. Correction of the CE angle, AHI and ARA was considered to be important in reducing the mechanical stress in the hip joint. Cite this article: Bone Joint J 2015;97-B:492–7.
The effect of frictional torque and bending moment on corrosion at the taper interface
Authors: Panagiotidou A. , Meswania J. , Osman K. , Bolland B. , Latham J. , Skinner J. , Haddad F. S. , Hart A. , Blunn G. 
Published: March 2015

The aim of this study was to assess the effect of frictional torque and bending moment on fretting corrosion at the taper interface of a modular femoral component and to investigate whether different combinations of material also had an effect. The combinations we examined were 1) cobalt–chromium (CoCr) heads on CoCr stems 2) CoCr heads on titanium alloy (Ti) stems and 3) ceramic heads on CoCr stems.In test 1 increasing torque was imposed by offsetting the stem in the anteroposterior plane in increments of 0 mm, 4 mm, 6 mm and 8 mm when the torque generated was equivalent to 0 Nm, 9 Nm, 14 Nm and 18 Nm.In test 2 we investigated the effect of increasing the bending moment by offsetting the application of axial load from the midline in the mediolateral plane. Increments of offset equivalent to head + 0 mm, head + 7 mm and head + 14 mm were used.Significantly higher currents and amplitudes were seen with increasing torque for all combinations of material. However, Ti stems showed the highest corrosion currents. Increased bending moments associated with using larger offset heads produced more corrosion: Ti stems generally performed worse than CoCr stems. Using ceramic heads did not prevent corrosion, but reduced it significantly in all loading configurations.Cite this article: Bone Joint J 2015;97-B:463–72.