bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breakfast Frequency and Development of Metabolic Risk
Authors: Odegaard Andrew O. , Jacobs David R. , Steffen Lyn M. , Van Horn Linda , Ludwig David S. , Pereira Mark A. 
Published: June 2013

OBJECTIVE
The relation of breakfast intake frequency to metabolic health is not well studied. The aim of this study was to examine breakfast intake frequency with incidence of metabolic conditions.

RESEARCH DESIGN AND METHODS
We performed an analysis of 3,598 participants from the community-based Coronary Artery Risk Development in Young Adults (CARDIA) study who were free of diabetes in the year 7 examination when breakfast and dietary habits were assessed (1992–1993) and participated in at least one of the five subsequent follow-up examinations over 18 years.

RESULTS
Relative to those with infrequent breakfast consumption (0–3 days/week), participants who reported eating breakfast daily gained 1.9 kg less weight over 18 years (P = 0.001). In a Cox regression analysis, there was a stepwise decrease in risk across conditions in frequent breakfast consumers (4–6 days/week) and daily consumers. The results for incidence of abdominal obesity, obesity, metabolic syndrome, and hypertension remained significant after adjustment for baseline measures of adiposity (waist circumference or BMI) in daily breakfast consumers. Hazard ratios (HRs) and 95% CIs for daily breakfast consumption were as follows: abdominal obesity HR 0.78 (95% CI 0.66–0.91), obesity 0.80 (0.67–0.96), metabolic syndrome 0.82 (0.69–0.98), and hypertension 0.84 (0.72–0.99). For type 2 diabetes, the corresponding estimate was 0.81 (0.63–1.05), with a significant stepwise inverse association in black men and white men and women but no association in black women. There was no evidence of differential results for high versus low overall dietary quality.

CONCLUSIONS
Daily breakfast intake is strongly associated with reduced risk of a spectrum of metabolic conditions.
Designing a Software Transactional Memory for Peer-To-Peer Systems
Authors: Paulovič Aurel , Lacko Peter 
Published: June 2013

AbstractTransactional memory is a rather novel approach to concurrency control in parallel computing, that has just recently found its way into distributed systems research. However, the research concentrates mainly on single processor solutions or cluster environment. In this paper we argue, that peer-to-peer systems would require a different design of transactional memory because of the increased failure-rate of nodes, slower network and possibility of network splits. We also present a few of our design ideas, namely increased performance and fault tolerance through the use of higher-level conflict detection and resolution via abstract data types and eventually consistency, that as we think could be important to a successful implementation of a scalable and resilient transactional memory.
The economic, financial and legal situation of private estates in Poland during the interwar period
Authors: Zając Stanisław 
Published: June 2013

Abstract
The bad economic situation for agro-forest farms in Poland during the interwar period was caused by war damage, a global economic crisis, crop failure, indebtedness prior to World War I, and by tribute payments towards rebuilding the country. Although the timber harvest was substantial, farm owners were forced to take loans. In 1938, the debt level of agro-forest farms accounted for 18 per cent of their total value. The average debt level for this period oscillated between 9.8 and 126.0 PLN/ha-1. The assistance programme implemented by the government provided for a reduction in the interest rate of loans, particularly for farms with an area up to 300 ha.
Growth of Ulmus glabra Huds. grafts in the clone archive in Bielsk Forest District
Authors: Mioduszewski Sławomir , Korczyk Adolf F. 
Published: June 2013

Abstract
Vegetative progeny were obtained from 46 elms (Ulmus glabra Huds.) by grafting. These grafted trees were planted in 2009 in a clone archive in forest plot 264j in the Bielsk Forest District.
After one year of growth, elm clone survival ranged from 38% to 100% (89% on average). Although all clones were of similar age and were grown under similar conditions, their average height was highly variable and ranged from 99.0 cm (clone no. 9473z) to 186.6 cm (clone no. 9645z), while average root collar diameter ranged from 8.4 mm (clone no. 9473z) to 18.0 mm (clone no. 9645z).
There were large differences crown architectural among the different clones, and variation in average shape of the crown was high (from 2.6 in clone no. 9655 to 3.8 in clone no. 9446z).
Index breeding values determined on the standardized data for height, root collar diameter, crown shape and survival, ranged from -0.71 (clone no. 9473z) to 0.61 (clone no. 9645z). Clones from Czerwony Dwór reached a better breeding value (0.17) than clones from Gołdap (-0.0266), and variation in their average breeding values was high (0.197).
Susceptibility of Polish provenances and families of pedunculate oak (Quercus robur L.) to colonisation by Phytophthora cambivora
Authors: Jankowiak Robert , Banach Jacek , Balonek Angelika 
Published: June 2013

Abstract
Phytophthora cambivora (Straminipila, Oomycota) causes root rot and stem canker on several deciduous tree species in Europe. However, very little is known about the variation in susceptibility to P. cambivora colonisation among provenances and families of pedunculate oak (Quercus robur L.). We studied variation in susceptibility of one French and 16 Polish provenances, representing 62 families. Samples were taken from three test plots located in the Brzesko Forest District. Oak susceptibility to P. cambivora was assessed by measuring lesion length following inoculation of excised shoots with two isolates of P. cambivora. There was significant variability in susceptibility among the 17 provenances tested. The highest susceptibility to P. cambivora was apparent in several provenances including Tronçais, Zaporowo, Runowo, Opole and Krotoszyn; while the most resistant provenances originated from Chojnów, Siedlce, Płock, Krotoszyn-90 and Wioska. There was also significant within-provenances variation in susceptibility to P. cambivora.
Osteoblastic bone metastases from renal cell carcinoma
Authors: Salapura Vladka , Zupan Irena , Seruga Bostjan , Gasljevic Gorana , Kavcic Pavel 
Published: June 2013

Abstract
Background. RCC accounts for only 2-3% of all cancers. Due to its’ non-specific symptoms disease is often diagnosed in advanced stage. Disseminated RCC frequently produces bone metastases that are almost always highly destructive, hyper vascularized and purely osteolytic.
Case report. In this article we describe a case of a 71-year old male patient with disseminated osteoblastic bone metastases from renal cell carcinoma (RCC), and present a short review of published literature reporting cases of osteoblastic bone metastases from RCC. Our patient presented with thoracic pain aggravated by movement. He was diagnosed with predominantly osteoblastic bone metastases in the skeleton of thoracic and lumbar vertebra along with metastases in iliac bones, ribs, humerus and clavicles. Initially, origin of bone metastases was unknown, but later a small tumor in patient’s right kidney was identified. Microscopic evaluation of the open bone biopsy showed clear cell RCC with sarcomatoid differentiation.
Conclusions. Although, due to its’ rarity, RCC is not included in the primary differential diagnosis in patients with osteoblastic metastases, such rare cases suggest that RCC may be considered in the diagnosis when there no other primary tumor is found
The role of extracellular vesicles in phenotypic cancer transformation
Authors: Ogorevc Eva , Kralj-Iglic Veronika , Veranic Peter 
Published: June 2013

AbstractBackground.Cancer has traditionally been considered as a disease resulting from gene mutations. New findings in biology are challenging gene-centered explanations of cancer progression and redirecting them to the non-genetic origins of tumorigenicity. It has become clear that intercellular communication plays a crucial role in cancer progression. Among the most intriguing ways of intercellular communication is that via extracellular vesicles (EVs). EVs are membrane structures released from various types of cells. After separation from the mother membrane, EVs become mobile and may travel from the extracellular space to blood and other body fluids.Conclusions.Recently it has been shown that tumour cells are particularly prone to vesiculation and that tumour-derived EVs can carry proteins, lipids and nucleic acids causative of cancer progression. The uptake of tumour-derived EVs by noncancerous cells can change their normal phenotype to cancerous. The suppression of vesiculation could slow down tumour growth and the spread of metastases. The purpose of this review is to highlight examples of EVmediated cancer phenotypic transformation in the light of possible therapeutic applications.
Management of intramedullary astrocytomas
Authors: Serban Daniel , Exergian Florin , Gorgan R.M. 
Published: June 2013

Abstract
Primitive IMT represent 8-10% of all primary tumors of the spinal cord. Only 2- 4% of all CNS tumors in adults are IMT. Adult astrocytomas are 25-35% of total IMT (1).
We prospectively analyzed clinical, imaging and pathological data from all consecutive patients operated for intramedullary tumors in our department (Neurosurgery I Clinic, Ward II) between January 2003 and August 2009 (80 months). All surgical interventions were performed by the same surgical team. We emphasized the technical difficulties raised by ablation of IMT depending on the type of the tumor and postoperative neurological outcome.
La mort à l'œuvre dans les écrits d'Hervé Guibert
Authors: Brun Anne 
Published: June 2013

L’œuvre d’Hervé Guibert (1955-1991) se définit comme une écriture et une mise en image du corps et évolue avec sa maladie du sida vers le spectacle de la dégénérescence de son corps devenu martyr. Une approche psychanalytique de ses derniers livres autobiographiques montre comment les sources du processus créateur consistent pour l’écrivain, confronté à la déchéance de son corps, à l’intrusion des nouvelles technologies médicales de soin et à la certitude de sa fin prochaine, à déployer dans l’écriture des stratégies de survie pour échapper à la mort. Cette écriture d’un corps extrême permet d’aborder les fonctions de la création dans le contexte d’une maladie mortelle. Cette œuvre met en lumière certains processus de survie chez des patients confrontés à des « situations extrêmes » de la subjectivité, dans différents contextes de rencontre clinique.
Inhaled Birch Pollen Extract Induces Airway Hyperresponsiveness via Oxidative Stress but Independently of Pollen-Intrinsic NADPH Oxidase Activity, or the TLR4–TRIF Pathway
Authors: Shalaby Karim H. , Allard-Coutu Alexandra , O’Sullivan Michael J. , Nakada Emily , Qureshi Salman T. , Day Brian J. , Martin James G. 
Published: June 2013

Abstract
Oxidative stress in allergic asthma may result from oxidase activity or proinflammatory molecules in pollens. Signaling via TLR4 and its adaptor Toll–IL-1R domain–containing adapter inducing IFN-β (TRIF) has been implicated in reactive oxygen species–mediated acute lung injury and in Th2 immune responses. We investigated the contributions of oxidative stress and TLR4/TRIF signaling to experimental asthma induced by birch pollen exposure exclusively via the airways. Mice were exposed to native or heat-inactivated white birch pollen extract (BPEx) intratracheally and injected with the antioxidants, N-acetyl-l-cysteine or dimethylthiourea, prior to sensitization, challenge, or all allergen exposures, to assess the role of oxidative stress and pollen-intrinsic NADPH oxidase activity in allergic sensitization, inflammation, and airway hyperresponsiveness (AHR). Additionally, TLR4 signaling was antagonized concomitantly with allergen exposure, or the development of allergic airway disease was evaluated in TLR4 or TRIF knockout mice. N-acetyl-l-cysteine inhibited BPEx-induced eosinophilic airway inflammation and AHR except when given exclusively during sensitization, whereas dimethylthiourea was inhibitory even when administered with the sensitization alone. Heat inactivation of BPEx had no effect on the development of allergic airway disease. Oxidative stress–mediated AHR was also TLR4 and TRIF independent; however, TLR4 deficiency decreased, whereas TRIF deficiency increased BPEx-induced airway inflammation. In conclusion, oxidative stress plays a significant role in allergic sensitization to pollen via the airway mucosa, but the pollen-intrinsic NADPH oxidase activity and TLR4 or TRIF signaling are unnecessary for the induction of allergic airway disease and AHR. Pollen extract does, however, activate TLR4, thereby enhancing airway inflammation, which is restrained by the TRIF-dependent pathway.
SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling
Authors: Dauphinee Shauna M. , Clayton Ashley , Hussainkhel Angela , Yang Cindy , Park Yoo-Jin , Fuller Megan E. , Blonder Josip , Veenstra Timothy D. , Karsan Aly 
Published: June 2013

Abstract
Recognition of microbial products by TLRs is critical for mediating innate immune responses to invading pathogens. In this study, we identify a novel scaffold protein in TLR4 signaling called SAM and SH3 domain containing protein 1 (SASH1). Sash1 is expressed across all microvascular beds and functions as a scaffold molecule to independently bind TRAF6, TAK1, IκB kinase α, and IκB kinase β. This interaction fosters ubiquitination of TRAF6 and TAK1 and promotes LPS-induced NF-κB, JNK, and p38 activation, culminating in increased production of proinflammatory cytokines and increased LPS-induced endothelial migration. Our findings suggest that SASH1 acts to assemble a signaling complex downstream of TLR4 to activate early endothelial responses to receptor activation.
Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination
Authors: Bonduelle Olivia , Yahia Nora , Siberil Sophie , Benhabiles Nora , Carrat Fabrice , Krivine Anne , Rozenberg Flore , Dimitrov Jordan , Kaveri Srini V. , Curjol Angélique , Tindel Malka , Louet Martine , Desert Florent , Launay Odile , Loulergue Pierre , Badre Gwenaelle , Katlama Christine , Bricaire François , Samri Assia , Rousset Dominique , van der Werf Sylvie , Jauréguiberry Stephane , Combadiere Behazine 
Published: June 2013

Abstract
Most vaccines, including those against influenza, were developed by focusing solely on humoral response for protection. However, vaccination activates different adaptive compartments that might play a role in protection. We took advantage of the pandemic 2009 A(H1N1) influenza vaccination to conduct a longitudinal integrative multiparametric analysis of seven immune parameters in vaccinated subjects. A global analysis underlined the predominance of induction of humoral and CD4 T cell responses, whereas pandemic 2009 A(H1N1)–specific CD8 responses did not improve after vaccination. A principal component analysis and hierarchical clustering of individuals showed a differential upregulation of influenza vaccine–specific immunity including hemagglutination inhibition titers, IgA+ and IgG+ Ab-secreting cells, effector CD4 or CD8 T cell frequencies at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination. This is related to individual factors including the magnitude and quality of influenza-specific immune responses before vaccination. We propose a graphical delineation of immune determinants that would be essential for a better understanding of vaccine-induced immunity in vaccination strategies.
HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 Monochain Transgenic/H-2 Class I Null Mice: Novel Versatile Preclinical Models of Human T Cell Responses
Authors: Boucherma Rachid , Kridane-Miledi Hédia , Bouziat Romain , Rasmussen Michael , Gatard Tanja , Langa-Vives Francina , Lemercier Brigitte , Lim Annick , Bérard Marion , BenMohamed Lbachir , Buus Søren , Rooke Ronald , Lemonnier François A. 
Published: June 2013

Abstract
We have generated a panel of transgenic mice expressing HLA-A*01:03, -A*24:02, -B*08:01, -B*27:05, -B*35:01, -B*44:02, or -C*07:01 as chimeric monochain molecules (i.e., appropriate HLA α1α2 H chain domains fused with a mouse α3 domain and covalently linked to human β2-microglobulin). Whereas surface expression of several transgenes was markedly reduced in recipient mice that coexpressed endogenous H-2 class I molecules, substantial surface expression of all human transgenes was observed in mice lacking H-2 class I molecules. In these HLA monochain transgenic/H-2 class I null mice, we observed a quantitative and qualitative restoration of the peripheral CD8+ T cell repertoire, which exhibited a TCR diversity comparable with C57BL/6 WT mice. Potent epitope-specific, HLA-restricted, IFN-γ–producing CD8+ T cell responses were generated against known reference T cell epitopes after either peptide or DNA immunization. HLA-wise, these new transgenic strains encompass a large proportion of individuals from all major human races and ethnicities. In combination with the previously created HLA-A*02:01 and -B*07:02 transgenic mice, the novel HLA transgenic mice described in this report should be a versatile preclinical animal model that will speed up the identification and optimization of HLA-restricted CD8+ T cell epitopes of potential interest in various autoimmune human diseases and in preclinical evaluation of T cell–based vaccines.
Utility of mobile devices in the computerized tomography evaluation of intracranial hemorrhage
Authors: Panughpath Sridhar G , Kumar Savith , Kalyanpur Arjun 
Published: June 2013

Abstract
Aim: To evaluate the utility of a mobile device to detect and assess intracranial hemorrhage (ICH) on head computed tomographys (CT) performed in the emergency setting. Materials and Methods: 100 head CT scans were randomly selected from our emergency radiology database and anonymized for patient demographics and clinical history. The studies were independently interpreted by two experienced radiologists in a blinded manner, initially on a mobile device (iPad, Apple computers) and subsequently, at an interval of one week, on a regular desktop workstation. Evaluation was directed towards detection, localization and characterization of hemorrhage. The results were assessed for accuracy, sensitivity, specificity and positive predictive value. Statistical significance was ascertained using Fisher′s exact test. Results: 27 of the examinations were positive for ICH, of which 11 had multiple hemorrhages. Of these there were 17 subdural, 18 intraparenchymal, 8 subarachnoid, 4 intraventricular and 2 extradural hemorrhages. In 96 of the studies there was complete concurrence between the iPad and desktop interpretations for both radiologists. Of 49 hemorrhages, 48 were accurately detected on the iPad by one of the radiologists. In the remaining case, a tiny intraventricular hemorrhage was missed by both radiologists on the iPad as well as on the workstation, indicating that the miss was more likely related to the very small size of the hemorrhage than the viewer used. Conclusion: We conclude that in the emergency setting, a mobile device with appropriate web-based pictue archiving and communication system (PACS) is effective in the detection of intracranial hemorrhage present on head CT.
Multimodality imaging of carotid atherosclerotic plaque: Going beyond stenosis
Authors: Hingwala Divyata , Kesavadas Chandrasekharan , Sylaja Padmavathy N , Thomas Bejoy , Kapilamoorthy Tirur Raman 
Published: June 2013

AbstractApart from the degree of stenosis, the morphology of carotid atherosclerotic plaques and presence of neovascularization are important factors that may help to evaluate the risk and ′vulnerability′ of plaques and may also influence the choice of treatment. In this article, we aim to describe the techniques and imaging findings on CTA, high resolution MRI and contrast enhanced ultrasound in the evaluation of carotid atherosclerotic plaques. We also discuss a few representative cases from our institute with the related clinical implications.
Quantitative Evaluation and Comparison of Stress Transmission Characteristics of Bar-Clip and Short Coping Overdenture Attachments Under Dynamic Loading: A Photoelastic Stress Analysis
Authors: Gupta Anurag , Dwivedi Alok , Vyas Rajesh 
Published: June 2013

ABSTRACT

Statement of problem
When two canine abutment teeth are used to support an overdenture prosthesis, optimal stress distribution to minimize forces to abutments is desired.

Purpose
This study used photoelastic stress analysis to compare the stress patterns generated around canine abutments using two different overdenture retainer designs.

Materials and methods
Two canine abutments were anchored in the photoelastic mandible and overdentures were fabricated using two different overdenture attachments. The fitting surface of dentures were lined with resilient layer of light bodied silicon rubberbase impression material to simulate oral mucosa. The attachments used were Bar-Clip and Short coping type. Verticalload of 5 to 50 lb was applied by jaw simulator. Resultant stress fringes were photographed and evaluated quantitatively.

Results
Bar-Clip type of attachment transmitted more amount of stress than short coping type transmitted. There was gross difference in magnitude of stresses between two types of retainers.

Conclusion
As the retentivity of the attachment increased there was more stress concentration around the abutments.

How to cite this article
Dwivedi A, Vyas R, Gupta A. Quantitative Evaluation and Comparison of Stress Transmission Characteristics of Bar-Clip and Short Coping Overdenture Attachments Under Dynamic Loading: A Photoelastic Stress Analysis. J Contemp Dent Pract 2013;14(2):287-292.
Tissue Inhibitor of Metalloproteinases-1 as a Biological Marker in Colorectal Cancer: Influence of Smoking on Plasma Levels?
Authors: Rasmussen Louise , Ladelund Steen , Brünner Nils , Jørgensen Lars N. , Nielsen Hans J. , Sørensen Lars T. 
Published: June 2013

Background At present plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) is undergoing validation as a biological marker in colorectal cancer (CRC). The clinical implementation of plasma TIMP-1 in prognosis, prediction, screening and monitoring CRC requires robust information as to the influence of preanalytical factors, including inter- and intrapersonal biological variations. The aim of the present study was to evaluate the possible effects of smoking on the level of TIMP-1 in plasma from healthy subjects. Materials and Methods Forty-six never-smokers and 48 daily smokers participated in the 13-week study. Smokers were randomized into 3 groups of 16 subjects each: one group continued to smoke, a second group refrained from smoking and used a transdermal nicotine patch, and a third group refrained from smoking and used placebo patches. Plasma TIMP-1 levels were determined using ELISA. Results No significant differences in TIMP-1 levels could be shown between the smoking group, the 2 different abstinent smoking groups and the never-smoking group. Conclusion Smoking does not appear to have any influence on TIMP-1 levels in plasma collected from healthy subjects.