bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case for open, viable print accounting
Authors: Kalochristianakis Michael 
Published: October 2014

Purpose
– This paper aims to describe the design and business characteristics of the system pertaining to efficient and viable public services, the technical perspective and also usage results from the productive prototype. When the academic library of our institution turned to consider cost-effective solutions that would combine management and accounting for both printing and photocopying, it was realized that there are no open-source or enterprise platforms that can support such characteristics. Instead of relying on commercial solutions, the construction of a service was planned by means of integrating community-based projects and developing any missing components.

Design/methodology/approach
– The implementation of the system was based on the identification of appropriate open-source modules and on the development of ones that do not exist but are necessary to realize business procedures for credit reception, control and billing. Thus, the system integrates software for the management of printers and print tasks, for accounting for printing tasks, for user catalogues, for authentication modules and for the control of low level I/O operations. The aforementioned systems were integrated along with the following new modules that were developed to create a complete service.

Findings
– Our prototype has been operating at our University since May 2011. The system was installed at four sites in reading rooms of the library. Three of them are located in different departments within the University campus, while the fourth is located in the last reading room that has not yet moved within the campus. In two years, more than 28,000 pages were printed and charged. The steady rise in the number of served requests leads us to the conclusion that the system can cope with the heavy use of photocopying machines.

Originality/value
– The prototype described in this paper is a complete productive platform that is capable to accept money or credit over the counter or by using money receivers and provide billing and management for printing and photocopying. The system does not depend on any vendor technology, offers control, monitoring, receipts and reports and because it relies on open source can minimize the total costs of ownership. Scrutiny of the bibliography and market did not find any systems that could meet the aforementioned characteristics.
Changes in biophysical properties of the skin following radiotherapy for breast cancer
Authors: Hu Stephen Chu‐Sung , Hou Ming‐Feng , Luo Kuei‐Hau , Chuang Hung‐Yi , Wei Shu‐Yi , Chen Gwo‐Shing , Chiang Wenchang , Huang Chih‐Jen 
Published: October 2014

AbstractAcute radiation dermatitis is a common adverse effect in patients undergoing radiotherapy for breast cancer. However, the effects of radiotherapy on biophysical properties of the skin have rarely been investigated. In this prospective cohort study, we seek to determine the effects of radiotherapy for breast cancer on skin biophysical parameters. We measured various skin biophysical parameters (skin hydration, pH, sebum level, pigmentation, and blood flow) in 144 breast cancer patients by non‐invasive techniques before and after radiotherapy. The measurements were simultaneously performed on the irradiated breast and the corresponding contralateral unirradiated breast for comparison. Following radiotherapy, the irradiated breast showed a significant decrease in skin hydration, increase in skin pH, increase in pigmentation, and increase in cutaneous blood flow. The contralateral unirradiated breast showed a slight increase in pigmentation but no significant changes in any of the other biophysical parameters after radiotherapy. No significant associations were found between patient characteristics (diabetes mellitus, hypertension, type of surgery, chemotherapy, hormone therapy) and changes in skin biophysical parameters following radiotherapy. In conclusion, radiation therapy for breast cancer induces measurable and significant changes in biophysical properties of the skin including hydration, pH, pigmentation, and blood flow. These findings give us a greater understanding of the effects of ionizing radiation on skin physiology, and provide non‐invasive and objective methods to assess radiation dermatitis.
Immunological response in Stevens–Johnson syndrome and toxic epidermal necrolysis
Authors: Abe Riichiro 
Published: October 2014

AbstractStevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life‐threatening cutaneous adverse drug reactions that induce widespread epidermal necrosis. Recent advances in pharmacogenomic studies have provided evidence of genetic predispositions to SJS/TEN. Several concepts have been proposed to explain the pathogenesis of severe cutaneous adverse drug reactions. In the hapten concept, small molecules called haptens elicit an immune response only when attached to proteins. The “p‐i” concept postulates that the causative drugs can stimulate cells by binding directly and reversibly to immune receptors. In addition, there is the idea that drugs alter the antigen by binding to the human leukocyte antigen pocket. With regard to keratinocyte death, several cell death mediators, such as FasL, granulysin and annexin A1, have been proposed as playing a role in SJS/TEN pathogenesis. A subset of T lymphocytes, including regulatory T cells, also may play a role in SJS/TEN.
Benefits, barriers and guideline recommendations for the implementation of serious games in education for stakeholders and policymakers
Authors: Tsekleves Emmanuel , Cosmas John , Aggoun Amar 
Published: October 2014

AbstractSerious games and game‐based learning have received increased attention in recent years as an adjunct to teaching and learning material. This has been well echoed in the literature with numerous articles on the use of games and game theory in education. Despite this, no policy for the incorporation of serious games in education exists to date. This review paper draws from the literature to provide guideline recommendations that would help educators and policymakers in making the first step towards this.
Fire Damage in Seasonally Flooded and Upland Forests of the Central Amazon
Authors: de Resende Angélica F. , Nelson Bruce W. , Flores Bernardo M. , de Almeida Danilo R. 
Published: October 2014

AbstractNeighboring upland and nutrient‐poor seasonally flooded Amazon forests were penetrated by a fire in 2009, providing a natural comparative experiment of fire damage for these widespread forest types. In upland, only 16 ± 10% (±2 SEM) of stems and 21 ± 8% of basal area were lost to fire, while seasonally flooded forest lost 59 ± 13% of stems and 57 ± 13% of basal area. Drier understory contributes to greater flammability. Much of the area occupied by seasonally flooded woody vegetation (>11.5 percent of the Amazon region) is vulnerable to fire due to high flammability and slow recovery.
Evaluating the Qualitative Effectiveness of a Novel Pollinator: a Case Study of Two Endemic Hawaiian Plants
Authors: Aslan Austin , Hart Patrick , Wu Joanna , Aslan Clare E. 
Published: October 2014

AbstractIn situations where native mutualists have become extinct, non‐native species may partner with remnant native species. However, non‐native mutualists may differ behaviorally from extinct native mutualists. In the case of pollination, novel relationships between natives and non‐natives could differ both quantitatively and qualitatively from native–native relationships. In Hawai'i, the non‐native Japanese White‐eye (Zosterops japonicus) has largely replaced endemic birds as pollinator of the endemic Clermontia parviflora and C. montis‐loa. We surveyed Clermontia patches and found that they ranged from 106 to 1198 m in diameter. We performed manual pollination of flowers with pollen taken from plants at five distance categories, ranging from 0 (self‐fertilization) to 20 km, and examined the germination of resulting seeds. We used radiotelemetry to estimate daily Japanese White‐eye movement distances. Percent germination of seeds after short‐ to intermediate‐distance pollination crosses (i.e., 20–1200 m, or intra‐patch pollen transfer distances) significantly exceeded germination of seeds from selfed trials for C. parviflora. No significant differences in germination rates among treatments were detected for C. montis‐loa. The maximum daily movement distances of radio‐tracked birds were generally <1 km. Together, these results suggest that this novel pollinator may be an effective mutualist for both Clermontia species. This study serves as an example of research examining qualitative components of novel mutualism, which are generally neglected relative to quantitative components.
Microclimate and Stream Noise Predict Geographic Divergence in the Auditory Signal of a Threatened Poison Frog
Authors: Vargas‐Salinas Fernando , Dorado‐Correa Adriana , Amézquita Adolfo 
Published: October 2014

AbstractAccording to the acoustic adaptation hypothesis, abiotic noise generated by streams should promote the evolution of high‐pitched signals in acoustically communicating animals. The putatively selective effect is best demonstrated by studying trait–environment correlations across recently or currently diverging lineages, and when we understand the ecological interactions that underlie the selective pressures. We studied microclimate, frog distribution, abiotic noise, and the frequency of the advertisement call of the Andean poison frogAndinobates bombetesacross variable environmental clines at five localities. Our general hypothesis involves three steps: microclimatic clines determine frogs’ distribution, which in turn is associated with different levels of abiotic noise that select for differentially pitched calls. Microclimate changed more abruptly with distance to streams in comparatively dry localities. There, frogs were more aggregated alongside streams and, in turn, experienced higher levels of abiotic noise. As predicted, frogs living alongside streams in dry forests called at higher frequencies, and thus attained comparable signal‐to‐noise ratios, compared with stream‐away frogs. Our data support a role for microclimate in determining frog distribution and thereby the noise conditions that promoted a divergence in a mate‐recognition signal.
Spiky follicular mycosis fungoides: a clinicopathologic study of 8 cases
Authors: Tomasini Carlo , Kempf Werner , Novelli Mauro , Fava Paolo , Annessi Giorgio , Rongioletti Franco , Fierro Maria Teresa , Quaglino Pietro 
Published: October 2014

BackgroundThe early stages of follicular mycosis fungoides (FMF) have not been described previously in the literature.ObjectiveOur goal was to better categorize the clinicopathologic features of early stages of FMF.MethodsThe clinical notes of patients with a diagnosis of FMF seen during the previous 5 years were reviewed to identify any cases that at presentation had only hyperkeratotic follicular lesions.ResultsEight patients (five male, three female) with a mean age of 55.4 years were enrolled. Noteworthy, FMF was not a clinical consideration in any of these patients initially. Patients presented with disseminated, slightly erythematous, hyperkeratotic, spiky follicular papules which, histopathologically, showed hyperkeratotic columns protruding from follicular plugging in concert with selective infiltration of the infundibular epithelium by atypical, mostly CD4+, lymphocytes. T‐cell clonality was demonstrated in four of eight cases. The mean duration of the lesions before diagnosis was 17.1 months. The course was indolent in most of the cases (median follow up: 18 months), whilst progression to overt FMF was noted in two patients.LimitationsThe number of cases is small and follow up relatively short.ConclusionsSpiky FMF is a deceptive clinicopathologic presentation of FMF that has been poorly described and that can mimic numerous follicular disorders.
Clinical and genetic investigation of 17 Japanese patients with hyperekplexia
Authors: Mine Jun , Taketani Takeshi , Yoshida Kazushi , Yokochi Fusako , Kobayashi Junpei , Maruyama Koichi , Nanishi Etsuro , Ono Mayumi , Yokoyama Atsushi , Arai Hidee , Tamaura Shiho , Suzuki Yasuhiro , Otsubo Shusuke , Hayashi Takashi , Kimura Masahiko , Kishi Kazuko , Yamaguchi Seiji 
Published: October 2014

AimThe aim of the study was to determine clinical and genetic characteristics of Japanese patients with hyperekplexia.MethodClinical courses, responses to antiepileptic drugs, outcomes, and genetic testing were investigated in 17 Japanese patients (nine males, eight females, median age 1y, range birth–45y) with hyperekplexia.ResultsIn all patients, muscle stiffness and startle responses appeared soon after birth. Only seven patients were diagnosed with hyperekplexia before 1 year of age. Seven patients had been misdiagnosed with other disorders such as epilepsy and adult‐onset anxiety neurosis. Umbilical/inguinal hernias were seen in 10 patients. Life‐threatening events were noted in four patients. Clonazepam was the most effective drug. Muscle stiffness completely disappeared in 12 patients before 5 years of age, whereas startle responses resolved in only three patients. Mutations in the GLRA1 and GLRB genes were identified in 16 patients and one patient respectively. In 14 patients, the mutation showed autosomal dominant inheritance; in the other three, inheritance was autosomal recessive. p.R271Q of GLRA1 was the most frequent mutation, found in 10 patients. Novel mutations, p.A272P and p.A384P of GLRA1, were detected. Clinical severity and outcome varied even in the same family.InterpretationEarly correct diagnosis is essential for prevention of accidental injuries and to provide appropriate treatments for hyperekplexia. Clonazepam is effective, although the time taken for startle responses to resolve varied.
From the Editors: Epilepsia's survey on the necessity of the Wada test and intracranial electrodes for cortical mapping
Authors: Mathern Gary W. , Beninsig Laurie , Nehlig Astrid 
Published: October 2014

SummaryObjectiveFrom April 4 to August 1, 2014, Epilepsia conducted an online survey seeking opinions related to the use of the Wada test and intracranial electrodes in localizing cortical functions for epilepsy surgery patients. This study reports the findings of that poll.MethodsThe survey consisted of six questions. Two questions addressed: (1) If a Wada test was always necessary for patients with temporal lobe epilepsy; and (2) if magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) data could replace intracranial electrodes in localizing cortical motor‐sensory and language functions. Four questions addressed the type of medical personnel, geographic region of residence based on International League Against Epilepsy (ILAE) regions, if responders had read the paper, and if they were ILAE/International Bureau for Epilepsy (IBE) members.ResultsOf 115 that started the survey, 92 (80%) completed it, and most were epilepsy specialists (87%) from North America (49%) and Europe (28%). Of responders, 85% indicated that Wada tests were unnecessary for temporal lobe epilepsy surgery patients. There were differences based on residency, with 100% of those from Europe indicating that the Wada test was unnecessary compared with 75% of those from North America (p = 0.01). Of responders, 56% indicated that intracranial electrodes were necessary to localize functional cortex.SignificanceThis survey found that the majority considered the Wada test unnecessary for temporal lobe epilepsy surgery patients, with more of those from Europe saying it is not needed compared with North America. In addition, just over half indicated that intracranial electrodes are still needed to localize motor‐sensory and language functions. These findings, although based on opinions, support that there are divergent views on the use of these procedures in epilepsy surgery patients that require additional study.
IL6 −174G>C polymorphism is associated with an increased risk of psoriasis but not response to treatment
Authors: Białecka Monika , Ostasz Roksana , Kurzawski Mateusz , Klimowicz Adam , Fabiańczyk Honorata , Bojko Piotr , Dziedziejko Violetta , Safranow Krzysztof , Droździk Marek 
Published: October 2014

AbstractInterleukin‐6 (IL‐6) is implicated in the pathogenesis of psoriasis as well as in its treatment efficacy. The aim of this study of 406 patients with psoriasis and 203 healthy controls was to evaluate the association between the IL6 −174G>C (rs1800795) polymorphism and psoriasis susceptibility, as well as treatment efficacy. The frequency of genotype GG (33.7% vs 20.7%; P = 0.00022; OR = 0.51, 95% confidence interval 0.34–0.76) and of allele G (56.2% vs 46.8%; P = 0.0023) was significantly higher in the psoriasis group compared with controls. No polymorphism variants were associated with better response to topical or combined topical/narrow‐band ultraviolet B (NB‐UVB) treatment. We conclude that the IL6 −174G>C polymorphism can be a marker of susceptibility to psoriasis, with an almost twofold increased risk of the disease in individuals carrying the GG genotype; however, it was not associated with treatment response to topical and/or NB‐UVB therapy.
Macrophyte effects on algal turbidity in subtropical versus temperate lakes: a reply to Dolman (2014)
Authors: Wang Hai‐Jun , Wang Hong‐Zhu 
Published: October 2014

Summary

Dolman (2014) argued that our recent finding (Wang et al., 2014) of no marked effect of submerged macrophytes on the chlorophyll a (Chl a) to total phosphorus (TP) relationship in Yangtze subtropical lakes may not necessarily be valid due to the statistical procedure used to analyse the relationship between these two variables.

We agree with Dolman (2014) that a likelihood ratio test could provide an alternative statistical approach to analyse the effect of macrophytes on Chl a versus TP. However, we do not consider it would be appropriate to use the test on only a limited sub‐data set corresponding to where TP values overlap for the vegetated and non‐vegetated states, as suggested by Dolman (2014).

Besides testing slopes of the log10(Chl a)–log10(TP) relationship, we compared log10(Chl a)/log10(TP) values between vegetated and non‐vegetated lakes at a range of overlapping TP concentrations (Wang et al., 2014).

The conclusion drawn by Dolman (2014) from a highly cited work on subtropical lakes in Florida was shown to be invalid. Re‐analysis of these lakes demonstrated similar results to those found in Yangtze subtropical lakes. We therefore consider that our original conclusions are valid and that submersed macrophytes in subtropical lakes do not necessarily exert the same strong effects on algal turbidity as in temperate lakes.
Compartment‐specific transcriptomics in a reef‐building coral exposed to elevated temperatures
Authors: Mayfield Anderson B. , Wang Yu‐Bin , Chen Chii‐Shiarng , Lin Chung‐Yen , Chen Shu‐Hwa 
Published: October 2014

AbstractAlthough rising ocean temperatures threaten scleractinian corals and the reefs they construct, certain reef corals can acclimate to elevated temperatures to which they are rarely exposedin situ. Specimens of the model Indo‐Pacific reef coralPocillopora damicorniscollected from upwelling reefs of Southern Taiwan were previously found to have survived a 36‐week exposure to 30°C, a temperature they encounter infrequently and one that can elicit the breakdown of the coral–dinoflagellate (genusSymbiodinium) endosymbiosis in many corals of the Pacific Ocean. To gain insight into the subcellular pathways utilized by both the coral hosts and their mutualisticSymbiodiniumpopulations to acclimate to this temperature,mRNAs from both control (27°C) and high (30°C)‐temperature samples were sequenced on an Illumina platform and assembled into a 236 435‐contig transcriptome. TheseP. damicornisspecimens were found to be ~60% anthozoan and 40% microbe (Symbiodinium, other eukaryotic microbes, and bacteria), from anmRNA‐perspective. Furthermore, a significantly higher proportion of genes from theSymbiodiniumcompartment were differentially expressed after two weeks of exposure. Specifically, at elevated temperatures,Symbiodiniumpopulations residing within the coral gastrodermal tissues were more likely to up‐regulate the expression of genes encoding proteins involved in metabolism than their coral hosts. Collectively, these transcriptome‐scale data suggest that the two members of this endosymbiosis have distinct strategies for acclimating to elevated temperatures that are expected to characterize many of Earth's coral reefs in the coming decades.
Structure and function of enterotoxigenic Escherichia coli fimbriae from differing assembly pathways
Authors: Mortezaei Narges , Epler Chelsea R. , Shao Paul P. , Shirdel Mariam , Singh Bhupender , McVeigh Annette , Uhlin Bernt Eric , Savarino Stephen J. , Andersson Magnus , Bullitt Esther 
Published: October 2014

SummaryPathogenic enterotoxigenic Escherichia coli (ETEC) are the major bacterial cause of diarrhea in young children in developing countries and in travelers, causing significant mortality in children. Adhesive fimbriae are a prime virulence factor for ETEC, initiating colonization of the small intestinal epithelium. Similar to other Gram‐negative bacteria, ETEC express one or more diverse fimbriae, some assembled by the chaperone‐usher pathway and others by the alternate chaperone pathway. Here, we elucidate structural and biophysical aspects and adaptations of each fimbrial type to its respective host niche. CS20 fimbriae are compared with colonization factor antigen I (CFA/I) fimbriae, which are two ETEC fimbriae assembled via different pathways, and with P‐fimbriae from uropathogenic E. coli. Many fimbriae unwind from their native helical filament to an extended linear conformation under force, thereby sustaining adhesion by reducing load at the point of contact between the bacterium and the target cell. CFA/I fimbriae require the least force to unwind, followed by CS20 fimbriae and then P‐fimbriae, which require the highest unwinding force. We conclude from our electron microscopy reconstructions, modeling and force spectroscopy data that the target niche plays a central role in the biophysical properties of fimbriae that are critical for bacterial pathophysiology.
A Semi‐empirical Bayesian Chart to Monitor Weibull Percentiles
Authors: Erto Pasquale , Pallotta Giuliana , Mastrangelo Christina M. 
Published: October 2014

AbstractThis paper develops a Bayesian control chart for the percentiles of the Weibull distribution, when both its in‐control and out‐of‐control parameters are unknown. The Bayesian approach enhances parameter estimates for small sample sizes that occur when monitoring rare events such as in high‐reliability applications. The chart monitors the parameters of the Weibull distribution directly, instead of transforming the data as most Weibull‐based charts do in order to meet normality assumption. The chart uses accumulated knowledge resulting from the likelihood of the current sample combined with the information given by both the initial prior knowledge and all the past samples. The chart is adapting because its control limits change (e.g. narrow) during Phase I. An example is presented and good average run length properties are demonstrated.