bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olfactory Impairment and Frailty
Authors: Yeo Brian Sheng Yep , Chan Jun He , Tan Benjamin Kye Jyn , Liu Xuandao , Tay Laura , Teo Neville Wei Yang , Charn Tze Choong 
Published: July 2024

ImportanceOlfactory impairment (OI) and frailty are prevalent conditions associated with aging, but studies investigating their association with each other have been discordant.ObjectiveTo summarize current evidence surrounding the association between OI and frailty.Data SourcesPubMed, Embase, Cochrane Library, SCOPUS, and CINAHL from inception to November 28, 2023.Study SelectionThis study included observational studies investigating the association between objectively or subjectively assessed OI and objectively evaluated frailty among adults.Data Extraction and SynthesisTwo independent authors extracted data into a structured template. Maximally adjusted estimates were pooled using a random-effects model, and statistical heterogeneity was evaluated using I2 values. Additional prespecified subgroup and sensitivity analyses were performed. This study used the Newcastle-Ottawa Scale for bias assessment and the Grading of Recommendations Assessment, Development and Evaluation framework for overall evidence quality evaluation.Main Outcomes and MeasuresThe primary outcome was the cross-sectional association between OI and frailty, for which the odds of frailty were compared between participants with and without OI. The secondary outcome was the cross-sectional association between frailty and OI, for which the odds of OI were compared between participants with and without frailty.ResultsThis study included 10 studies with 10 624 patients (52.9% female; mean [SD] age, 62.9 [9.6] years). The Newcastle-Ottawa Scale score of studies ranged from low to moderate. Grading of Recommendations Assessment, Development and Evaluation scores ranged from low to moderate. OI was associated with a 2.32-fold (odds ratio [OR], 2.32; 95% CI, 1.63-3.31; I2 = 0%) greater odds of frailty compared with individuals with healthy olfactory function. The odds of OI was progressively greater with categorical frailty status, with a 1.55-fold (OR, 1.55; 95% CI, 1.32-1.82; I2 = 0%), 2.28-fold (OR, 2.28; 95% CI, 1.96-2.65; I2 = 0%), and 4.67-fold (OR, 4.67; 95% CI, 2.77-7.86; I2 = 0%) increase in odds for individuals with prefrailty, frailty, and the most frailty, respectively, compared with robust individuals. The results demonstrated stability in subgroup analyses (geographical continent of study, objective vs subjective olfactory assessment) and sensitivity tests.Conclusions and RelevanceThe results of this systematic review and meta-analysis suggest that there is an association between OI and frailty, with an increase in the odds of OI with worsening categorical frailty status among individuals with prefrailty, frailty, and the most frailty. OI may be a potential biomarker for frailty. Future studies could delve into whether OI may be a modifiable risk factor for frailty.
A method for empirically validating FMEA RPN scores in a radiation oncology clinic using physics QC data
Authors: Kim Leonard H. , Juneja Badal R. , Viscariello Natalie N. 
Published: July 2024

AbstractIn failure modes and effects analysis (FMEA), the components of the risk priority number (RPN) for a failure mode (FM) are often chosen by consensus. We describe an empirical method for estimating the occurrence (O) and detectability (D) components of a RPN. The method requires for a given FM that its associated quality control measure be performed twice as is the case when a FM is checked for in an initial physics check and again during a weekly physics check. If instances of the FM caught by these checks are recorded, O and D can be computed. Incorporation of the remaining RPN component, Severity, is discussed. This method can be used as part of quality management design ahead of an anticipated FMEA or afterwards to validate consensus values.
Supramolecular 3D Printing Enabling One‐Step Generation of Healable and Recyclable Structurally Colored Objects
Authors: Hu Zhen , Li Miaomiao , Lyu Quanqian , Chen Xiaodong , Zhang Xiujuan , Yu Ying , Zhang Lianbin , Zhu Jintao 
Published: July 2024

AbstractStructurally colored objects with 3D geometries are intriguing in optical devices and visual sensors, but their preparation is bottlenecked by complicated procedures and limited material choices. Herein, a facile supramolecular 3D printing strategy is proposed via direct ink writing (DIW) supramolecular colloidal inks (SCIs) consisting of polymers and colloids based on supramolecular interactions to construct healable and recyclable structurally colored objects. Optimized supramolecular interactions balance the rheological requirements for DIW and the high particle volume fraction for the one‐step and immediate generation of structural color. The shear‐thinning and thixotropy features of the SCIs, characterized by a two‐order‐of‐magnitude decrease in viscosity during the printing process and 50% storage modulus recovery thereafter, ensure the reversible solid–liquid transition during the extrusion and deposition process. The short‐range ordered arrangements of colloids within the matrix give rise to angle‐independent structural color. Moreover, 3D structurally colored objects from the SCIs are healable and, more importantly, can be closed‐looped recycled thanks to the reversibility of supramolecular interactions. Leveraging optimized supramolecular interactions, various SCIs with a wide range of material choices meeting the DIW process are extended to construct 3D structurally colored objects directly. This study paves the way for constructing advanced 3D materials with a supramolecular strategy.
Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation
Authors: Krymchenko Roman , Coşar Kutluoğlu Gizem , van Hout Noor , Manikowski Dominique , Doberenz Claudia , van Kuppevelt Toin H. , Daamen Willeke F. 
Published: July 2024

AbstractElastin, a fibrous extracellular matrix (ECM) protein, is the main component of elastic fibers that are involved in tissues’ elasticity and resilience, enabling them to undergo reversible extensibility and to endure repetitive mechanical stress. After wounding, it is challenging to regenerate elastic fibers and biomaterials developed thus far have struggled to induce its biosynthesis. This review provides a comprehensive summary of elastic fibers synthesis at the cellular level and its implications for biomaterial formulation, with a particular focus on dermal substitutes. The review delves into the intricate process of elastogenesis by cells and investigates potential triggers for elastogenesis encompassing elastin‐related compounds, ECM components, and other molecules for their potential role in inducing elastin formation. Understanding of the elastogenic processes is essential for developing biomaterials that trigger not only the synthesis of the elastin protein, but also the formation of a functional and branched elastic fiber network.
Super Stable Silk Nanofibrils Prepared by an Improved Exfoliation Method and Their Related Applications
Authors: Chen Ling , Liu Wen , Xiao Menglin , Sun Liangyan , Chen Xiaoxuan , Ni Lingyue , Yao Jinrong , Shao Zhengzhong , Zhao Bingjiao , Chen Xin 
Published: July 2024

AbstractThe high crystallinity and sophisticated hierarchical architecture of native animal silk endow it with comprehensive mechanical properties that are superior to those of most synthetic fibers. However, these features also make the direct exfoliation of silk nanofibrils (SNFs) highly challenging. On the other hand, silk‐based materials prepared by conventional method (i.e., through silk fibroin aqueous solution) are usually weak, so the preparation methods based on SNFs have attracted much attention in recent years. Herein, a facile and environmentally friendly route is developed to directly exfoliate SNFs from natural Bombyx mori silkworm silk via ammonium persulfate oxidation followed by ultrasonication. The obtained SNFs have a high yield (nearly 40%) and are well dispersed in water in a wide pH range, so they can act as a good starting material to prepare subsequent silk‐based materials. The main application of the SNFs demonstrated in this article is a curcumin (Cur)/SNFs hydrogel as wound dressing. In vivo experimental results show that the Cur/SNFs hydrogel significantly enhanced the healing rate of wounds on diabetic mice. Therefore, the preparation method developed in this study provides an efficient way to produce SNFs, which have great potential for a wide range of applications, including as wound dressings for diabetics.
A Green, Fire‐Retarding Ether Solvent for Sustainable High‐Voltage Li‐Ion Batteries at Standard Salt Concentration
Authors: Xia Dawei , Tao Lei , Hou Dong , Hu Anyang , Sainio Sami , Nordlund Dennis , Sun Chengjun , Xiao Xianghui , Li Luxi , Huang Haibo , Lin Feng 
Published: July 2024

AbstractLithium‐ion batteries (LIBs) are increasingly encouraged to enhance their environmental friendliness and safety while maintaining optimal energy density and cost‐effectiveness. Although various electrolytes using greener and safer glyme solvents have been reported, the low charge voltage (usually lower than 4.0 V vs Li/Li+) restricts the energy density of LIBs. Herein, tetraglyme, a less‐toxic, non‐volatile, and non‐flammable ether solvent, is exploited to build safer and greener LIBs. It is demonstrated that ether electrolytes, at a standard salt concentration (1 m), can be reversibly cycled to 4.5 V vs Li/Li+. Anchored with Boron‐rich cathode‐electrolyte interphase (CEI) and mitigated current collector corrosion, the LiNi0.8Mn0.1Co0.1O2 (NMC811) cathode delivers competitive cyclability versus commercial carbonate electrolytes when charged to 4.5 V. Synchrotron spectroscopic and imaging analyses show that the tetraglyme electrolyte can sufficiently suppress the overcharge behavior associated with the high‐voltage electrolyte decomposition, which is advantageous over previously reported glyme electrolytes. The new electrolyte also enables minimal transition metal dissolution and deposition. NMC811||hard carbon full cell delivers excellent cycling stability at C/3 with a high average Coulombic efficiency of 99.77%. This work reports an oxidation‐resilient tetraglyme electrolyte with record‐high 4.5 V stability and enlightens further applications of glyme solvents for sustainable LIBs by designing Boron‐rich interphases.
Ce‐Doping Rather Than CeO2 Modification and Their Synergistic Effect: Promotion from Ce Species in the Electrocatalytic Oxidation of 5‐Hydroxymethylfurfural Over NiFe–LDH
Authors: Zhang Yanyan , Hai Guangtong , Huang Zhuoshen , Liu Zhimeng , Huang Xiubing , Wang Ge 
Published: July 2024

AbstractElectrocatalytic oxidation of 5‐hydroxymethylfurfural (HMFOR) is an effective route to produce value‐added chemicals with low energy consumption. In this work, efficient electrocatalysts are prepared by varying the amount of Ce doping and CeO2 modification on NiFe layered double hydroxide (NiFe–LDH) nanosheets supported on carbon cloth (CC). Through Ce doping and heterogeneous interface construction, the electronic structure and coordination chemistry of NiFe–LDH are greatly changed. Compared to CeO2 modification and the synergistic effect of Ce‐doping and CeO2 modification, CC@NiFeCe(3%)‐LDH with only Ce‐doping show excellent charge transfer ability, higher HMF conversion (95.73%), 2,5‐furandicarboxylic acid (FDCA) selectivity (93.31%), and Faraday efficiency (99.47%) at only 1.44 VRHE. Density‐functional theory calculations and X‐ray fine structure spectroscopy demonstrate that Ce doping, compared with CeO2 modification and their synergistic effects, significantly facilitates the electron transport and optimizes intermediate adsorption by effectively lowering the activation energy for the transformation of 5‐formyl‐2‐furancarboxylic acid (FFCA) and encourage the conversion of FFCA to FDCA. Overall, this work systemically investigates the HMFOR behaviors of CC@NiFe–LDH under Ce doping, CeO2 modification, and their synergetic effect, which provides some guidance on the development of high‐performance electrocatalysts for HMFOR performance.
Exceptional Nitrate Reduction to Ammonia Catalyst Enabled by BO2− Anion Induction Effects Combining Heterogeneous Branching Architecture‐Driven Mass Transport Enhancement
Authors: Ding Liping , Yan Han , Zhang Lin , Bai Ruijie , Du Qian , Xu Chun , Gu Haojie , Guo Suer , Cheng Guoxia , Fu Qiaomei , Liu Siqi , Yin Kang , Li Qi , Wang Yanqing 
Published: July 2024

AbstractIn this paper, an exceptional nitrate reduction to ammonia catalyst is reported, enabled by BO2− anion induction effects combining heterogeneous branching architecture‐driven mass transport enhancement strategies. The implantation of the BO2− anion can inductively enhance the electron cloud density and electron transmission paths of intrinsic catalysts, makes electron more active to improve the conductivity, regulates the adsorption and desorption rates of intermediates by space barrier effect, reduces the binding energy of the electron and 3d orbital of Ni in NiFe(BO2)O(OH), thereby lowing the transform free energy of the determining *NO3 to *HNO3 step. 3D hollow sea urchin lattice heterogeneous branching structure can self‐drive generate differentiated micro convection intervals, which will be beneficial for improving mass transfer dynamics especially localized disturbance mass transfer effect of catalyst for nitrate reduction reaction (NO3RR) catalysis process. Amazingly, the as‐prepared 3D NiFe metaborate oxyhydroxide hollow bionic sea urchins lattice catalyst has a high NH3 rate 6.27mmol·h−1·cm−2 with 98.7% Faradaic efficiency at low ‐0.25V(vs RHE) NO3RR potential. Moreover, the catalytic activity of this highly stable catalyst decreases only slightly over 100 h at ultra‐high 1500mA·cm−2 current. This work breaks through the bottleneck that plagues the performance improvement of non Cu‐based high‐current NO3RR catalysts.
Measuring leaf and root functional traits uncovers multidimensionality of plant responses to arbuscular mycorrhizal fungi
Authors: Stahlhut Katherine N. , Neupert Deannah G. , Laing Josie E. , Witt Lydia J. , Bauer Jonathan T. 
Published: July 2024

AbstractPremiseWhile many studies have measured the aboveground responses of plants to mycorrhizal fungi at a single time point, little is known about how plants respond belowground or across time to mycorrhizal symbiosis. By measuring belowground responses and growth over time in many plant species, we create a more complete picture of how mycorrhizal fungi benefit their hosts.MethodsWe grew 26 prairie plant species with and without mycorrhizal fungi and measured 14 functional traits to assess above‐ and belowground tissue quality and quantity responses and changes in resource allocation. We used function‐valued trait (FVT) modeling to characterize changes in species growth rate when colonized.ResultsWhile aboveground biomass responses were positive, the response of traits belowground were much more variable. Changes in aboveground biomass accounted for 60.8% of the variation in mycorrhizal responses, supporting the use of aboveground biomass response as the primary response trait. Responses belowground were not associated with aboveground responses and accounted for 18.3% of the variation. Growth responses over time were highly variable across species. Interestingly, none of the measured responses were phylogenetically conserved.ConclusionsMycorrhizal fungi increase plant growth in most scenarios, but the effects of these fungi belowground and across time are more complicated. This study highlights how differences in plant allocation priorities might affect how they utilize the benefits from mycorrhizal fungi. Identifying and characterizing these differences is a key step to understanding the effects of mycorrhizal mutualisms on whole plant physiology.
Total adiponectin in indigenous Melanesians on Kitava
Authors: Carrera‐Bastos Pedro , Fontes‐Villalba Maelán , Ahrén Bo , Lindblad Ulf , Råstam Lennart , Frostegård Johan , Åkerfeldt Torbjörn , Granfeldt Yvonne , Sundquist Kristina , Jönsson Tommy 
Published: July 2024

AbstractObjectivesExperimental and small human studies have indicated that high total adiponectin levels have beneficial cardiometabolic effects. In contrast, however, high total adiponectin levels are also associated with higher all‐cause and cardiovascular mortality in thoroughly adjusted epidemiological studies. To gain further insight into these seemingly contradictory results, we report results on total adiponectin from the indigenous Melanesian population of Kitava, Trobriand Islands, Papua New Guinea, where an apparent absence of cardiometabolic disease has been previously reported.MethodsFasting levels of serum total adiponectin were measured cross‐sectionally in ≥40‐year‐old Kitavans (n = 102) and Swedish controls matched for age and sex (n = 108). Multivariable linear regression was used for the analysis of associations with total adiponectin when controlled for group, sex, smoking, hypertension and/or type 2 diabetes, age, and body mass index.ResultsTotal adiponectin was lower for Kitavans compared to Swedish controls (Median [Mdn] 4.6 μg/mL, range 1.0–206 μg/mL and Mdn 9.7 μg/mL, range 3.1–104 μg/mL, respectively, r = .64, p < .001). Lower total adiponectin was associated with Kitavan group, male sex (only in Swedish controls), smoking (only in Kitavans and Swedish controls combined), younger age (not in Swedish controls), higher BMI, lower total, low‐density lipoprotein, high‐density lipoprotein (HDL) (only in Kitavans and Swedish controls combined), and non‐HDL cholesterol, and higher anti‐PC IgG (only in Kitavans and Swedish controls combined).ConclusionTotal adiponectin in Kitavans was significantly lower than in Swedish controls.
Chitosan‐based crosslinking for controlled topical drug release in rhinosinusitis
Authors: Cho Do‐Yeon , Lim Dong Jin , Kelly Olivia J. , Skinner Daniel , Zhang Shaoyan , Jones Martin P. , Grayson Jessica , Woodworth Bradford A. 
Published: July 2024

Key points
Chitosan is a promising drug delivery vector for therapeutics owing to its biocompatibility.
Once crosslinked with chitosan, prolonged drug release was noted regardless of hydrophilicity.
Hydrophilic drugs may require different strategies to obtain a sustained release profile.
Applications and advancements in animal models for antiviral research on mosquito‐borne arboviruses
Authors: Tang Megan Caifeng , Wong Ka Heng , Azman Adzzie Shazleen , Lani Rafidah 
Published: July 2024

AbstractVector‐borne diseases caused by arthropod‐borne viruses (arboviruses) are a considerable challenge to public health globally. Mosquito‐borne arboviruses, such as Chikungunya, Dengue, and Zika viruses, cause a range of human illnesses and may be fatal. Currently, efforts to control these diseases still face challenges due to growing vector resistance towards insecticides, urbanization, and limited effective antiviral treatments and vaccines. Animal models are crucial in antiviral research on mosquito‐borne arboviruses, playing a role in understanding disease mechanisms, vaccine development, and toxicity testing, but the application of animal models still faces the challenges of ethical considerations and animal‐to‐human translational success. Genetically engineered mouse models, hamster models and non‐human primate (NHP) are currently used in arbovirus research, but new models such as tree shrews and novel humanized mice are emerging. In the context of Malaysian research, the use of long‐tailed macaques as potential NHP models for arbovirus research is possible; however, it faces the ethical dilemma of using an endangered species for scientific purposes. Overall, animal models play a crucial role in advancing infectious disease research, but a balance between medical research and species conservation must be upheld.
Strain‐Release‐Driven Modular Synthesis of Oxetane‐Based Amide Bioisosteres: Concise, Robust and Scalable Approach
Authors: Spránitz Péter , Sőregi Petra , Hegedüs Kristóf , Igriczi Barbara , Szakács Gergely , Jemnitz Katalin , Szabó Pál , Galushchak Yarema , Mykhailiuk Pavel K. , Soós Tibor 
Published: July 2024

AbstractAmide bioisoterism is a widely used strategy in drug development to fine‐tune physicochemical, pharmacokinetic, and metabolic properties, eliminate toxicity and gain intellectual property rights in uncharted chemical space. Of these, oxetane‐amines offer particularly exciting possibilities as bioisosteres, although they are less frequently investigated than warranted due to the lack of simple and widely applicable synthetic methods. Herein, we report a two‐step, practical, modular, robust, and scalable method for the construction of oxetane‐containing amide bioisosteres that relies on the readily available oxetan‐3‐one. This operationally simple procedure exploits the enhanced reactivity of the keto group of the commercially available oxetan‐3‐one to form amine‐benzotriazole intermediates, which springloaded adducts are then reacted with various aliphatic and aromatic organometallic reagents under mild conditions to afford various amino‐oxetanes in good to high yields. The simplicity and broad applicability of the method greatly facilitates the synthesis of derivatives that were previously difficult or impossible to produce. The usefulness of this method in the field medicinal chemistry was also demonstrated by eliminating the well‐known metabolic problem of ketoconazole.
Non‐Classical Deactivation Mechanism in a Supported Intermetallic Catalyst for Propane Dehydrogenation
Authors: Tian Jinshu , Kong Ru , Deng Bin , Cheng Yi , Hu Kerou , Zhong Zhangnan , Sun Tulai , Tan Mingwu , Chen Luwei , Zhao Jia , Wang Yong , Li Xiaonian , Zhu Yihan 
Published: July 2024

AbstractPlatinum‐based supported intermetallic alloys (IMAs) demonstrate exceptional performance in catalytic propane dehydrogenation (PDH) primarily because of their remarkable resistance to coke formation. However, these IMAs still encounter a significant hurdle in the form of catalyst deactivation. Understanding the complex deactivation mechanism of supported IMAs, which goes beyond conventional coke deposition, requires meticulous microscopic structural elucidation. In this study, we unravel a nonclassical deactivation mechanism over a PtZn/γ‐Al2O3 PDH catalyst, dictated by the PtZn to Pt3Zn nanophase transformation accompanied with dezincification. The physical origin lies in the metal support interaction (MSI) that enables strong chemical bonding between hydroxyl groups on the support and Zn sites on the PtZn phase to selectively remove Zn species followed by the reconstruction towards Pt3Zn phase. Building on these insights, we have devised a solution to circumvent the deactivation by passivating the MSI through surface modification of γ‐Al2O3 support. By exchanging protons of hydroxyl groups with potassium ions (K) on the γ‐Al2O3 support, such a strategy significantly minimizes the dezincification of PtZn IMA via diminished metal‐support bonding, which dramatically reduces the deactivation rate from 0.2044 to 0.0587 h−1. These findings decode the nonclassical PDH deactivation mechanism over supported IMA catalysts and elaborate a new logic for the design of high‐performance IMA based PDH catalysts with long‐term stability.