bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Ionotropic NMDA Receptor Signaling Drives Activity-Induced Dendritic Spine Shrinkage
Authors: Stein Ivar S. , Gray John A. , Zito Karen 
Published: September 2015

The elimination of dendritic spine synapses is a critical step in the refinement of neuronal circuits during development of the cerebral cortex. Several studies have shown that activity-induced shrinkage and retraction of dendritic spines depend on activation of the NMDA-type glutamate receptor (NMDAR), which leads to influx of extracellular calcium ions and activation of calcium-dependent phosphatases that modify regulators of the spine cytoskeleton, suggesting that influx of extracellular calcium ions drives spine shrinkage. Intriguingly, a recent report revealed a novel non-ionotropic function of the NMDAR in the regulation of synaptic strength, which relies on glutamate binding but is independent of ion flux through the receptor (Nabavi et al., 2013). Here, we tested whether non-ionotropic NMDAR signaling could also play a role in driving structural plasticity of dendritic spines. Using two-photon glutamate uncaging and time-lapse imaging of rat hippocampal CA1 neurons, we show that low-frequency glutamatergic stimulation results in shrinkage of dendritic spines even in the presence of the NMDARd-serine/glycine binding site antagonist 7-chlorokynurenic acid (7CK), which fully blocks NMDAR-mediated currents and Ca2+transients. Notably, application of 7CK or MK-801 also converts spine enlargement resulting from a high-frequency uncaging stimulus into spine shrinkage, demonstrating that strong Ca2+influx through the NMDAR normally overcomes a non-ionotropic shrinkage signal to drive spine growth. Our results support a model in which NMDAR signaling, independent of ion flux, drives structural shrinkage at spiny synapses.SIGNIFICANCE STATEMENTDendritic spine elimination is vital for the refinement of neural circuits during development and has been linked to improvements in behavioral performance in the adult. Spine shrinkage and elimination have been widely accepted to depend on Ca2+influx through NMDA-type glutamate receptors (NMDARs) in conjunction with long-term depression (LTD) of synaptic strength. Here, we use two-photon glutamate uncaging and time-lapse imaging to show that non-ionotropic NMDAR signaling can drive shrinkage of dendritic spines, independent of NMDAR-mediated Ca2+influx. Signaling through p38 MAPK was required for this activity-dependent spine shrinkage. Our results provide fundamental new insights into the signaling mechanisms that support experience-dependent changes in brain structure.
Epigenetic Profiling Identifies Novel Genes for Ascending Aortic Aneurysm Formation with Bicuspid Aortic Valves
Authors: Shah Asad A 
Published: September 2015

<p><strong>Background: </strong>Bicuspid aortic valves predispose to ascending aortic aneurysms, but the mechanisms underlying this aortopathy remain incompletely characterized. We sought to identify epigenetic pathways predisposing to aneurysm formation in bicuspid patients.</p><p><strong>Methods: </strong>Ascending aortic aneurysm tissue samples were collected at the time of aortic replacement in subjects with bicuspid and trileaflet aortic valves. Genome-wide DNA methylation status was determined on DNA from tissue using the Illumina 450K methylation chip, and gene expression was profiled on the same samples using Illumina Whole-Genome DASL arrays. Gene methylation and expression were compared between bicuspid and trileaflet individuals using an unadjusted Wilcoxon rank sum test. </p><p><strong>Results: </strong>Twenty-seven probes in 9 genes showed significant differential methylation and expression (P&lt;5.5x10<sup>-4</sup>). The top gene was protein tyrosine phosphatase, non-receptor type 22 (<em>PTPN22</em>), which was hypermethylated (delta beta range: +15.4 to +16.0%) and underexpressed (log 2 gene expression intensity: bicuspid 5.1 vs. trileaflet 7.9, P=2x10<sup>-5</sup>) in bicuspid patients, as compared to tricuspid patients. Numerous genes involved in cardiovascular development were also differentially methylated, but not differentially expressed, including <em>ACTA2</em> (4 probes, delta beta range: -10.0 to -22.9%), which when mutated causes the syndrome of familial thoracic aortic aneurysms and dissections</p><p><strong>Conclusions: </strong>Using an integrated, unbiased genomic approach, we have identified novel genes associated with ascending aortic aneurysms in patients with bicuspid aortic valves, modulated through epigenetic mechanisms. The top gene was <em>PTPN22</em>, which is involved in T-cell receptor signaling and associated with various immune disorders. These differences highlight novel potential mechanisms of aneurysm development in the bicuspid population.</p>
Open Distal Anastomosis Technique for Ascending Aortic Aneurysm Repair without Cerebral Perfusion
Authors: Kaplan Mehmet , Temur Bahar , Can Tolga , Abay Gunseli , Olsun Adlan , Aydogan Hakki 
Published: September 2015

<p><strong>Background</strong><strong>: </strong>This study aimed to report the outcomes of patients who underwent proximal thoracic aortic aneurysm surgery with open distal anastomosis technique but without cerebral perfusion, instead under deep hypothermic circulatory arrest.</p><p><strong>Methods: </strong>Thirty patients (21 male, 9 female) who underwent ascending aortic aneurysm repair with open distal anastomosis technique were included. The average age was 60.2±11.7 years. Operations were performed under deep hypothermic circulatory arrest and the cannulation for cardiopulmonary bypass was first done over the aneurysmatic segment and then moved over the graft. Intraoperative and early postoperative mortality and morbidity outcomes were reported.</p><p><strong>Results</strong><strong>: </strong>Average duration of cardiopulmonary bypass and cross-clamps were 210.8±43 and 154.9±35.4 minutes, respectively. Average duration of total circulatory arrest was 25.2±2.4 minutes. There was one hospital death (3.3%) due to chronic obstructive pulmonary disease at postoperative day 22. No neurological dysfunction was observed during the postoperative period.<strong></strong></p><p><strong>Conclusion: </strong>These results demonstrate that open distal anastomosis under less than 30 minutes of deep hypothermic circulatory arrest without antegrade or retrograde cerebral perfusion and cannulation of the aneurysmatic segment is a safe and reliable procedure in patients undergoing proximal thoracic aortic aneurysm surgery.</p><p> </p>
The Suramadu Bridge Affair: Un-bridging the State and the Kyai in New Order Madura
Authors: Pribadi Yanwar 
Published: September 2015

This paper by and large explores state-society relations and for the most part discusses the Indonesian government’s plans to ‘modernize’ Madura during the New Order administration and how a number of kyai responded to these plans. Specifically, it is concerned with a conflict between the state and the kyai in the Suramadu Bridge Affair, particularly in the rejection of the industrialization scheme by the Kyai of Bassra. An obvious aspect that can be highlighted from the conflict is the inability of state officials, especially at regional levels, to cope with the high expectations of the central government. Another central aspect underlined is the undemocratic approach of the government towards the implementation of its plans. The government’s plans to ‘modernize’ Madura eventually created resistance among some segments in society, and they made use of, among other things, Islamic symbols in resisting the government’s plans.DOI: 10.15408/sdi.v22i2.1919
Poet in an Islamic Community: Cultural and Social Activities of Acep Zamzam Noor in Tasikmalaya, West Java
Authors: Moriyama Mikihiro 
Published: September 2015

This article brings out the significance of social leader in the time of socio-political change in Indonesia since Soeharto left office in 1998 by describing and analyzing the projects and writings including poems of Acep Zamzam Noor (born in 1960), an activist and poet based in the Pesantren Cipasung (Cipasung Islamic school complex) in Tasikmalaya, West Java. He is respected not by his Islamic knowledge based on learning books, rather by his faith to God and deed based on his own experience. Acep’s oppositional stance in relation to political and religious authorities is manifest in various public projects including political parody and cultural activities in the local community. These respective projects constituted bases for the respect and support from which the institution of the social leader derives its significance in Islamic communities in Indonesia. This article adds to the literature by describing and analyzing an important stand of religious authority.DOI: 10.15408/sdi.v22i2.1920
Acceso y uso de los dispositivos portátiles de la población estudiantil de primaria a bachillerato: Estudio de caso en Ensenada, México
Authors: Organista Sandoval Javier , Serrano Santoyo Arturo 
Published: September 2015

El artículo identifica los principales dispositivos portátiles e Internet que disponen los estudiantes de Educación Primaria, Secundaria y Bachillerato en Ensenada, México y se determina la frecuencia y restricción de su uso en los espacios escolares. Se construyó un indicador de nivel socio-tecnológico (NST) con base en siete variables asociadas con posesiones tecnológicas y servicios en la vivienda para ubicar a estudiantes adscritos a escuelas con NST alto y bajo. Estas variables se recuperaron de la información demográfica publicada por el Instituto Nacional de Estadística y Geografía (INEGI). Se desarrolló una encuesta para recuperar información general de los estudiantes, de sus posesiones tecnológicas, del contexto de uso, entre otros. La encuesta se aplicó a 1972 estudiantes de las escuelas seleccionadas. La posesión de Internet en el NST alto fue mayor al 90% en todos los niveles, mientras que en el NST bajo de Educación Primaria apenas llega a 57%. Los resultados muestran una cobertura superior al 90% en cuanto a computadora y teléfono celular, el mayor porcentaje de posesión de tabletas (46%) corresponde a estudiantes de Educación Primaria. Al comparar las posesiones tecnológicas de los estudiantes en el NST alto y bajo, se encontraron diferencias significativas (p&lt;0.05) en cuanto a la posesión de equipo de cómputo y tabletas. Se destaca que la mayoría de los estudiantes lleva su teléfono a la escuela, sin embargo, se prohíbe su uso. Los hallazgos muestran que 2 de cada 5 estudiantes cuentan con los tres dispositivos. Esta condición anticipa una generación de estudiantes con mayores recursos tecnológicos y con posibilidad de apoyar sus estudios. <em> </em>
Programmable Skins based on Core-Shell Microsphere/Nanotube/Polymer Composites
Authors: Panchapakesan Balaji , Onal Cagdas , Loomis James 
Published: September 2015

ABSTRACTIn this paper, we describe unique thermally responsive polymer system based on nanotube-elastomers dispersed with core-shell expanding microspheres (phase-change material). Upon thermal or infrared stimuli, liquid hydrocarbon cores encapsulated within the microspheres vaporize, expanding the surrounding shells and stretching the matrix. Microsphere transformation resulted in visible dimensional changes associated with macroscopic volume increase (>500%), reduction in density (>80%), and increase in elastic modulus (>675%). Additionally, electrically conductive nanotubes allowed for expansion dependent electrical responses. We present our new findings on expansion dependent superhydrophobicity in these materials and present some outlook and comparison of our stimuli responsive polymers with other material systems for future origami based applications.
Patient Attitudes Regarding the Cost of Illness in Cancer Care
Authors: Meisenberg Barry R. , Varner Ashley , Ellis Erin , Ebner Stephen , Moxley John , Siegrist Erika , Weng David 
Published: September 2015

Abstract

Background and Purpose.
The cost of illness in cancer care and the subsequent distress has attracted scrutiny. Guidelines recommend enhanced discussion of costs, assuming this will reduce both stress and costs. Little is known about patient attitudes about cost considerations influencing treatment decisions.

Methods.
A convenience-sample survey of patients currently receiving radiation and/or intravenous chemotherapy at an outpatient cancer center was performed. Assessments included prevalence and extent of financial burden, level of financial distress, attitudes about using costs to influence treatment decisions, and frequency or desirability of cost discussions with oncologists.

Results.
A total of 132 participants (94%) responded. Overall, 47% reported high financial stress, 30.8% felt well informed about costs prior to treatment, and 71% rarely spoke to their oncologists about cost. More than 71% of patients did not want either society's or personal costs to influence treatment, and this result did not change based on degree of financial stress. Even when asked to assume that lower cost regimens were equally effective, only 28% would definitely want the lower cost regimen. Patients did not believe it was the oncologist's duty to perform cost discussions.

Conclusion.
Even insured patients have a high degree of financial distress. Most, including those with the highest levels of distress, did not speak often with oncologists about costs and were strongly adverse to having cost considerations influence choice of regimen. The findings suggest that patients are not cost sensitive with regard to treatment decisions. Oncologists will require improved tools to have meaningful cost discussion, as recommended by the American Society of Clinical Oncology.

Implications for Practice:
This study raises important questions regarding optimal communication with patients about costs. If patients are not cost sensitive regarding treatment decisions, they will not be full partners in the desire to reduce financial burden and financial distress by lowering costs. Better patient educational tools are needed to help increase not just cost awareness but also awareness of value. To master this mode of discourse and to help ease patients’ financial toxicity, oncologists will need to master a new set of data and develop new skills. This new knowledge and proficiency are as vital to good oncology care as all other clinical acumen.
Vergelijkingen en verbindingen De arbeidsdeelname van vrouwen in Nederland en Nederlands-Indië, 1813-1940
Authors: Van Nederveen Meerkerk Elise 
Published: September 2015

Comparisons and Connections: Women’s Labour Force Participation in the Netherlands and the Netherlands-Indies, 1813-1940Elise van Nederveen Meerkerk investigates the extent to which colonial ties between the Netherlands and the Netherlands East-Indies influenced women’s labour patterns in the colony as well as the metropolis. On the one hand, comparisons are made between quantitative and qualitative developments in women’s labour force participation in the Netherlands and the Netherlands Indies in the colonial period. On the other hand, various connections are made between developments in the metropolis and the colony. Not only did Dutch economic and colonial policies, such as the Cultivation System and the exports of Dutch textiles by the Dutch Trading Company (nhm), lead to changes in women’s work in both regions. Moreover, social policy, for instance the Social Question and Ethical Policy, also influenced legislation on and practices of women’s work in colony and metropolis. The underlying rhetorics were generally patronising, containing elements of class, ethnicity and gender to justify intervention (and the differences therein) in both parts of the empire. This article is part of the special issue 'De Vrouw 1813-1913' and was nominated for the first Low Countries History Award in 2016 (for the best article in BMGN - Low Countries Historical Review over the years 2013-2014-2015). Vergelijkingen en verbindingen De arbeidsdeelname van vrouwen in Nederland en Nederlands-Indië, 1813-1940Elise van Nederveen Meerkerk onderzoekt in hoeverre de koloniale banden tussen Nederland en Nederlands-Indië de arbeidspatronen van zowel vrouwen in de kolonie als vrouwen in het moederland beïnvloedden. Enerzijds wordt een vergelijking gemaakt van de ontwikkelingen in de arbeidsdeelname van vrouwen in Nederland en Nederlands-Indië in de koloniale periode, in kwantitatief en kwalitatief opzicht. Anderzijds worden verschillende verbindingen gelegd tussen ontwikkelingen in het moederland en de kolonie. Niet alleen het economische en koloniale beleid van Nederland, zoals het Cultuurstelsel en de exporten van Nederlands textieldoor de Nederlandsche Handel-Maatschappij (nhm), leidde tot veranderingen in vrouwenarbeid in beide regio’s. Ook het sociaal beleid, zoals de ‘Sociale Quaestie’ en de Ethische Politiek, beïnvloedde de wetgeving en praktijk van de arbeid van vrouwen in moederland en kolonie. De retoriek hierachter was meestal bevoogdend, en bevatte elementen van klasse, etniciteit en gender ter verantwoording van het ingrijpen (en de verschillen daarin) in beide delen van het koloniale rijk. Dit artikel maakt deel uit van het themanummer 'De Vrouw 1813-1913'.
Vrouw en opvoeding sinds de late negentiende eeuw. Het bijzondere van de Nederlandse casus
Authors: Dekker Jeroen J.H. 
Published: September 2015

Women and Child Rearing since the Late Nineteenth Century: The Speciality of the Dutch CaseIn the last two centuries only a few people would contest that Dutch mothers should raise their children. Until the end of the nineteenth century this task often went together with women’s labour. From that point until the 1960s there was a special period in Dutch history, with the great majority of mothers devoting themselves full-time to motherhood and only a very small minority working outside the home. This deviation from a European pattern – almost a Dutch Sonderweg in the first half of the twentieth century – changed into another deviation from the 1970s. Then more and more Dutch mothers started to work outside the home, eventually even in greater numbers than in other European countries, but with the majority of mothers preferring part-time work. As a result, it became a matter of course for Dutch mothers to combine working outside the home with raising their own children. This article is part of the special issue 'De Vrouw 1813-1913'. Dat Nederlandse vrouwen hun eigen kinderen behoren op te voeden is een opvatting die in de laatste tweehonderd jaar weinig is aangevochten. Tot het einde van de negentiende eeuw ging dat vaak samen met vrouwenarbeid. Toen ontstond een bijzondere Nederlandse situatie waarbij tot in de jaren zestig bijna alle moeders zich volledig aan het moederschap wijdden en nauwelijks buitenshuis werkten. Deze afwijking van het Europese patroon – een Nederlandse Sonderweg – veranderde vanaf de jaren zeventig in haar omkering toen gehuwde vrouwen steeds vaker gingen werken, zelfs vaker dan moeders in andere Europese landen. Ook in een ander opzicht pakten Nederlandse moeders het anders aan dan inandere Europese landen: ze werkten in meerderheid in deeltijd. Tegelijk werken en opvoeden van de eigen kinderen werden vanaf toen een vanzelfsprekendheid. Dit artikel maakt deel uit van het themanummer 'De Vrouw 1813-1913'.
Multipurpose Masculinities: Gender and Power in Low Countries Histories of Masculinity
Authors: Dudink Stefan 
Published: September 2015

This article introduces the contributions to a BMGN - Low Countries Historical Review special issue on Low Countries masculinities. It outlines a shared theoretical framework that focuses on what historian Mrinalini Sinha has called, 'the rhetorical and ideological efficacy' of notions of masculinity 'in underwriting various arrangements of power'. The article's central argument is that the history of masculinity should move 'beyond masculinity' by analysing the deployment of masculinity in the making, legitimisation and contestation of not just power relations of gender, but also other power relations. It points to the origins of this framework in post-structuralist strands of women's and gender history and evaluates critically the usefulness of the notion of 'hegemonic masculinity' for such an approach. This article is part of the special issue 'Low Countries Histories of Masculinity'.
Voorbij Bijltjesdag? Recente werken over de bestraffing van collaboratie na beide wereldoorlogen in de Lage Landen
Authors: Grevers Helen 
Published: September 2015

Lijst van besproken publicaties: Guido Abuys, Bas Kortholt, Interneringskamp Westerbork. Verhalen van een vergeten verleden 1945-1948 (Hilversum: Just Publishers, 2010, 175 p. + dvd, ISBN 978 90 8975 143 0)Guillaume Baclin, Laurence Bernard, Xavier Rousseaux, En première ligne: La justice militaire belge face à ‘l’incivisme’ au sortir de la Première Guerre Mondiale (Études sur la Première Guerre mondiale. Studies over de Eerste Wereldoorlog. Studies on World War One 16; Bruxelles: Archives générales du Royaume, 2010, 249 pp., ISBN 978 90 5746 257 3)Koos Groen, Fout en niet goed. De vervolging van collaboratie en verraad na de Tweede Wereldoorlog (Hilversum: Just Publishers, 2009, 695 p., ISBN 978 90 77895 64 1)Xavier Rousseaux, Laurence Van Ypersele (eds.), La Patrie crie vengeance! La Répression des ‘inciviques’ belges au sortir de la guerre 1914-1918 (Histoire; Bruxelles: Le Cri, 2008, 437 pp., ISBN 978 2 8710 6493 0)Frank Seberechts, Frans-Jos, Verdoodt, Leven in twee werelden. Belgische collaborateurs en de diaspora na de Tweede Wereldoorlog (Leuven: Davidsfonds, 2010, 236 p., ISBN 978 90 5826 664 4)Jan Sintemaartensdijk, Yfke Nijland, Operatie Black Tulip. De uitzetting van Duitse Burgers na de oorlog (Amsterdam: Boom, 2009, 175 p., ISBN 978 90 8506 808 2)Pierre-Alain Tallier, Patrick Nefors (eds.), Quand les canons se taisent. En toen zwegen de kanonnen. When the Guns fall Silent. Actes du colloque international organisé par les Archives de l’État et le Musée royal de l’Armée et d’Histoire militaire (Bruxelles, 3-6 novembre 2008) (Études sur la Première Guerre mondiale. Studies over de Eerste Wereldoorlog. Studies on World War One 18; Bruxelles: Archives générales du Royaume, 2010, 631 pp., ISBN 978 90 5746 284 9)Marc Van den Wijngaert, e.a., Beulen van Breendonk. Schuld en boete (Antwerpen: Standaard, 2010, 223 p., ISBN 978 90 02 23956 4)