bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiologically‐based pharmacokinetic model of in vitro porcine ear skin permeation for drug delivery research
Authors: Krumpholz Laura , Polak Sebastian , Wiśniowska Barbara 
Published: August 2024

AbstractIn silico techniques, such as physiologically based pharmacokinetic modeling (PBKP), are recently gaining importance. Computational methods in drug discovery and development and the generic drugs industry enhance research effectiveness by saving time and money and avoiding ethical issues. One key advantage is the ability to conduct toxicology studies without risking harm to living beings. This study aimed to repurpose the multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) PBPK model for simulation permeation through porcine ear skin under in vitro conditions. The work was divided into four steps: (1) the development of a pig ear skin model based on a previously collected dataset; (2) testing the model's ability to discriminate permeation between pig ear, human abdomen, and human back skin; (3) development of a caffeine permeation model; and (4) testing the caffeine model's performance against in vitro generated data sourced from the scientific literature. Data from 31 manuscripts were used for the development of the pig skin model. Based on these data, values specific to pig skin were found for 22 parameters of the MPML MechDermA model. The model was able to discriminate permeation between pig and human skin. A caffeine model was developed and used to simulate seven experiments identified in the literature. The model's performance was assessed by comparing simulated to observed results. Based on a visual check, all simulations were considered acceptable, whereas three out of seven experiments met the twofold difference criterion. The variability of the experimental data was considered the biggest challenge for reliable model assessment.
Effect of photobiomodulation in an experimental in vitro model of asthma‐Copd overlap
Authors: Guerra Marina Bertoni , Santana Kelly Gomes , Momolli Marcos , Labat Rodrigo , Chavantes Maria Cristina , Zammuner Stella Regina , Júnior José Antonio Silva , da Palma Renata Kelly , Aimbire Flavio , de Oliveira Ana Paula Ligeiro 
Published: August 2024

AbstractThe objective of the study was to evaluate the effect of photobiomodulation (PBM) with laser on the inflammatory process in an experimental in vitro model of ACO. The groups were: (1) human bronchial epithelial cells (BEAS‐2B); (2) BEAS‐2B cells treated with dexamethasone; (3) BEAS‐2B cells irradiated with laser; (4) BEAS‐2B cells stimulated with cigarette smoke extract (CSE) + House Dust Mite (HDM); (5) BEAS‐2B cells stimulated with CSE + HDM and treated with dexamethasone; (6) BEAS‐2B cells incubated with CSE + HDM and irradiated with laser. After 24 h, cytokines were quantified. There was a reduction in TNF‐α, IL‐1β, IL‐6, IL‐4, IL‐5, IL‐13, IL‐17, IL‐21, IL‐23, and an increase in IL‐10 and IFN‐γ in cells from the laser‐irradiated ACO group compared to only ACO group. With these results, we can suggest that photobiomodulation acts in the modulation of inflammation observed in ACO, and may be a treatment option.
Extended benchmark set for lattice parameters of inorganic solids
Authors: Lima Elodie Fernandes , Bredow Thomas 
Published: August 2024

AbstractThe development of novel methods in solid‐state quantum chemistry necessitates reliable reference data sets for their assessment. The most fundamental solid‐state property of interest is the crystal structure, quantified by the lattice parameters. In the last decade, several studies were conducted to assess theoretical approaches based on the agreement of calculated lattice parameters with respect to experiment as a measure. However, most of these studies used a limited number of reference systems with high symmetry. The present work offers a more comprehensive reference benchmark denoted as Sol337LC, which consists of 337 inorganic compounds with 553 symmetry‐inequivalent lattice parameters, representing every element of the periodic table for atomic numbers between 1 and 86, except noble gases, the radioactive elements and lanthanoids. The reference values were taken from earlier benchmarks and from measurements at very low temperature or extrapolation to 0 K. The experimental low‐temperature lattice parameters were then corrected for zero‐point energy effects via the quasi‐harmonic approximation for direct comparison with quantum‐chemical optimized structures. A selection of standard density functional approximations was assessed for their deviations from the experimental reference data. The calculations were performed with the crystal orbital program CRYSTAL23, applying optimized atom‐centered basis sets of triple‐zeta plus polarization quality. The SCAN functional family and the global hybrid functional PW1PW, augmented with the D3 dispersion correction, were found to provide closest agreement with the Sol337LC reference data.
Anxiety during transition from primary to secondary schools in neurodivergent children
Authors: Sideropoulos Vassilis , Palikara Olympia , Burchell Elizabeth , Ashworth Maria , Van Herwegen Jo 
Published: August 2024

AbstractTransition from primary to secondary school is an educational milestone that coincides with other key developmental changes associated with the onset of adolescence. Although previous studies have examined the impact of school transition on autistic students, no studies thus far have examined whether the impacts experienced are similar across different neurodivergent populations. In this paper, we examined how the transition to secondary school affects anxiety experienced by autistic children, children with Down syndrome (DS) and Williams syndrome (WS). Sixty‐one parents completed an online survey at two time‐points, answering questions about their neurodivergent child's anxiety, adjustment, well‐being, skills, and experiences of the transition to secondary school. The children themselves completed a short interview, which included completing a set of standardised measures with a researcher. Both neurodivergent children and parents expressed concerns about bullying and adjustment to new environments during transition from primary to secondary school. Although wide variability was found in our sample, no significant differences were revealed in the overall levels of parent‐reported anxiety pre‐ and post‐transition. However, different factors predicted anxiety during pre‐ and post‐school transition. The impact of these findings for theory and practice are discussed.
Functional near‐infrared spectroscopy and language development: An integrative review
Authors: Januário Gabriela Cintra , Bertachini Ana Lívia Libardi , Escarce Andrezza Gonzalez , de Resende Luciana Macedo , de Miranda Débora Marques 
Published: August 2024

AbstractFunctional near‐infrared spectroscopy (fNIRS) stands poised to revolutionize our understanding of auditory detection, speech perception, and language development in infants. In this study, we conducted a meticulous integrative review across Medline, Scopus, and LILACS databases, targeting investigations utilizing fNIRS to explore language‐related features and cortical activation during auditory stimuli in typical infants. We included studies that used the NIRS technique to study language and cortical activation in response to auditory stimuli in typical infants between 0 and 3 years old. We used the ROBINS‐I tool to assess the quality and the risk of bias in the studies. Our analysis, encompassing 66 manuscripts, is presented in standardized tables for streamlined data extraction. We meticulously correlated findings with children's developmental stages, delineating crucial insights into brain development and its intricate interplay with language outcomes. Although most studies have a high risk for overall bias, especially due to the high loss of data in NIRS studies, the low risk in the other domains is predominant and homogeneous among the studies. Highlighted are the unique advantages of fNIRS for pediatric studies, underscored by its innate suitability for use in children. This review accentuates fNIRS' capacity to elucidate the neural correlates of language processing and the sequential steps of language acquisition. From birth, infants exhibit abilities that lay the foundation for language development. The progression from diffuse to specific neural activation patterns is extremely influenced by exposure to languages, social interaction, and prosodic features and, reflects the maturation of brain networks involved in language processing. In conclusion, fNIRS emerges as an indispensable functional imaging modality, providing insights into the temporal dynamics of language acquisition and associated developmental milestones. This synthesis presents the pivotal role of fNIRS in advancing our comprehension of early language development and paves the way for future research endeavors in this domain.
Assessment of blood viral load in asymptomatic and symptomatic cases of congenital cytomegalovirus infection
Authors: Güneş Ömer , Gülhan Belgin , Üçkardeş Fatih , Güney Ahmet Yasin , Coşkun Zehra Nihan , Özen Seval , Kanık‐Yüksek Saliha , Özkaya‐Parlakay Aslınur 
Published: August 2024

AbstractThis study aimed to retrospectively evaluate the baseline and follow‐up viral loads and viral clearance times in cases followed for asymptomatic and symptomatic congenital cytomegalovirus (cCMV) infection between August 2010 and August 2022. Among 93 cases, they had asymptomatic (n: 55) and symptomatic (n: 38). The median baseline blood viral load detected in the symptomatic cCMV (ScCMV) infection (13 054 IU/mL) was significantly higher than that of asymptomatic cCMV (AcCMV) infection (4636 IU/mL) (p < 0.013). There was no difference in median viral clearance times (75 and 90 days, respectively) in baseline viremic cases in the ScCMV and AcCMV infection groups. There were no differences in median baseline blood viral load (6930 IU/mL and 14 268 IU/mL, respectively) and median viral clearance times (75 and 85 days, respectively) between the 6‐week and 6‐month antiviral treatment group. No correlation was found between baseline blood viral load, clinical severity, and the number of systems involved. However, in initial viremic cases, the viral load threshold for a symptomatic case was 8856 IU/mL, with 85.7% sensitivity and 54.5% specificity.
Activation of neurotoxic A1‐reactive astrocytes by SFTS virus infection accelerates fatal brain damage in IFNAR1‐/‐ mice
Authors: Kim Seon‐Hee , Choi Ha Nyeoung , Jo Min Gi , Lee Bina , Kim Young Jin , Seong Hyemin , Song Chieun , Yoo Han Sol , Lee Jeong Hyun , Seong Daseul , Park Hyun‐Jin , Roh In‐Soon , Yang Jinsung , Lee Min Young , Kim Hye Jung , Park Sang Won , Kim Mingyo , Kim Seong Jae , Kim Minkyeong , Kim Hyun‐Jeong , Hong Kyung‐Wook , Yun Seung Pil 
Published: August 2024

AbstractSevere fever with thrombocytopenia syndrome (SFTS) has a high mortality rate compared to other infectious diseases. SFTS is particularly associated with a high risk of mortality in immunocompromised individuals, while most patients who die of SFTS exhibit symptoms of severe encephalitis before death. However, the region of brain damage and mechanisms by which the SFTS virus (SFTSV) causes encephalitis remains unknown. Here, we revealed that SFTSV infects the brainstem and spinal cord, which are regions of the brain associated with respiratory function, and motor nerves in IFNAR1‐/‐ mice. Further, we show that A1‐reactive astrocytes are activated, causing nerve cell death, in infected mice. Primary astrocytes of SFTSV‐infected IFNAR1‐/‐ mice also induced neuronal cell death through the activation of A1‐reactive astrocytes. Herein, we showed that SFTSV induces fatal neuroinflammation in the brain regions important for respiratory function and motor nerve, which may underlie mortality in SFTS patients. This study provides new insights for the treatment of SFTS, for which there is currently no therapeutic approach.
Functionalization of Filter Media for Improved Crystalline Silica Analysis Using Raman Spectroscopy
Authors: Elahifard Mohammadreza , Wang Xiaoliang , Chow Judith C. , Watson John G. 
Published: August 2024

ABSTRACTRespirable crystalline silica (RCS) poses significant health risks in workplaces, including underground coal mines, metal and nonmetal mining, construction sites, fire suppression, and oil and gas industries. Raman spectroscopy offers a promising avenue for direct analysis of RCS on sample filters with minimal pretreatment. However, the presence of organic compounds (OC) in the samples can generate fluorescence signals that interfere with RCS measurements, potentially saturating the detector even at short integration times, particularly when using portable Raman instruments. This study explores a novel approach to address these challenges by functionalizing filters with a hydroxyapatite/silver bromide/titanium dioxide (HAT) photocatalyst, facilitating the oxidation and removal of OC using the Raman excitation laser. Photocatalytic degradation experiments conducted on polyvinyl chloride (PVC) filters preloaded with HAT and anatase titanium dioxide (TiO2) particles demonstrated that HAT significantly enhances the degradation of OC, such as oxalic acid, under visible light irradiation compared to TiO2. Additionally, fluorescence interferences were reduced for coal dust samples analyzed on functionalized silver filters using a portable Raman instrument. The efficacy of HAT in OC photocatalytic degradation on silver filters was further confirmed using a benchtop micro‐Raman system. Filter functionalization had minimal impact on filtration efficiencies and pressure drops, indicating the feasibility of this approach for improving RCS analysis while maintaining filter performance.
A re‐analysis of about 60,000 sparse data meta‐analyses suggests that using an adequate method for pooling matters
Authors: Schulz Maxi , Kramer Malte , Kuss Oliver , Mathes Tim 
Published: August 2024

AbstractIn sparse data meta‐analyses (with few trials or zero events), conventional methods may distort results. Although better‐performing one‐stage methods have become available in recent years, their implementation remains limited in practice. This study examines the impact of using conventional methods compared to one‐stage models by re‐analysing meta‐analyses from the Cochrane Database of Systematic Reviews in scenarios with zero event trials and few trials. For each scenario, we computed one‐stage methods (Generalised linear mixed model [GLMM], Beta‐binomial model [BBM], Bayesian binomial‐normal hierarchical model using a weakly informative prior [BNHM‐WIP]) and compared them with conventional methods (Peto‐Odds‐ratio [PETO], DerSimonian‐Laird method [DL] for zero event trials; DL, Paule‐Mandel [PM], Restricted maximum likelihood [REML] method for few trials). While all methods showed similar treatment effect estimates, substantial variability in statistical precision emerged. Conventional methods generally resulted in smaller confidence intervals (CIs) compared to one‐stage models in the zero event situation. In the few trials scenario, the CI lengths were widest for the BBM on average and significance often changed compared to the PM and REML, despite the relatively wide CIs of the latter. In agreement with simulations and guidelines for meta‐analyses with zero event trials, our results suggest that one‐stage models are preferable. The best model can be either selected based on the data situation or, using a method that can be used in various situations. In the few trial situation, using BBM and additionally PM or REML for sensitivity analyses appears reasonable when conservative results are desired. Overall, our results encourage careful method selection.
A cold‐adapted and robust alkaline lipase from Marinobacter nanhaiticus boosts laundry detergent performance
Authors: Cai Qinzhou , Zhang Huifang , Zhao Bingshan , Ren Lei , Wang Yonghua , Wang Fanghua 
Published: August 2024

AbstractCold‐adapted, alkali‐stable lipases with surfactant tolerance are highly sought after in the detergent industry. In this study, we recombinantly expressed and characterized a novel lipase from Marinobacter nanhaiticus (MNL). The purified MNL exhibited high stability within a temperature range of 10–30°C and pH values of 8–10, demonstrating optimal activity at 20°C and pH 8. MNL has a preference for substrates with medium chains with the best activity being 3768.6 U/mg using p‐nitrophenyl decanoate as a substrate. Remarkably, MNL showed enhanced enzymatic activity in the presence of ionic surfactants and displayed notable resilience when exposed to proteases. Washing performance analysis further revealed MNL's high proficiency in removing oil‐based stains from fabrics. Collectively, these results suggest that MNL holds significant promise as a valuable component in laundry detergent formulations.
Comprehensive review of combustion ion chromatography for the analysis of total, adsorbable, and extractable organic fluorine
Authors: Shelor Charles Phillip , Warren Cable , Odinaka Chimauchem V. , Dumre Kalpana 
Published: August 2024

Poly‐ and perfluoroalkyl substances (PFAS) are a class of persistent organic pollutants whose high stability and appreciable water solubility have led to near‐global contamination. PFAS are bioaccumulative toxins that have been linked to a myriad of disorders and have been detected nearly universally in human blood. Liquid chromatography‐tandem mass spectrometry is the most frequent method used for quantitation, though this typically only measures a few dozen of the >14 000 known PFAS and has been shown to account for a small portion of the total organic fluorine present. Sum parameter methods such as total, extractable, and adsorbable organic fluorine have emerged as alternative measurements for PFAS determination. Combustion ion chromatography has become the preferred method for organofluorine measurement where the sorbent or extract containing PFAS is combusted and the emitted hydrofluoric acid (HF) is a measure of the cumulative organofluorine present. Herein we critically review the types of organofluorine measurement, their separation from the sample matrix, and key parameters of the analytical instrument that affect sensitivity, reproducibility, and recovery with regards to PFAS analysis.
Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson's Disease: Exploratory Outcomes and Open‐Label Extension
Authors: Lizarraga Karlo J. , Gnanamanogaran Bhairavei , Al‐Ozzi Tameem M. , Cohn Melanie , Tomlinson George , Boutet Alexandre , Elias Gavin J.B. , Germann Jürgen , Soh Derrick , Kalia Suneil K. , Hodaie Mojgan , Munhoz Renato P. , Marras Connie , Hutchison William D. , Lozano Andres M. , Lang Anthony E. , Fasano Alfonso 
Published: August 2024

AbstractBackgroundA randomized trial suggested that reducing left‐sided subthalamic stimulation amplitude could improve axial dysfunction.ObjectivesTo explore open‐label tolerability and associations between trial outcomes and asymmetry data.MethodsWe collected adverse events in trial participants treated with open‐label lateralized settings for ≥3 months. We explored associations between trial outcomes, location of stimulation and motor asymmetry.Results14/17 participants tolerated unilateral amplitude reduction (left‐sided = 10, right‐sided = 4). Two hundred eighty‐four left‐sided and 1113 right‐sided stimulated voxels were associated with faster gait velocity, 81 left‐sided and 22 right‐sided stimulated voxels were associated with slower gait velocity. Amplitude reduction contralateral to shorter step length was associated with 2.4‐point reduction in axial MDS‐UPDRS. Reduction contralateral to longer step length was associated with 10‐point increase in MDS‐UPDRS.ConclusionsLeft‐sided amplitude reduction is potentially more tolerable than right‐sided amplitude reduction. Right‐sided more than left‐sided stimulation could be associated with faster gait velocity. Shortened step length might reflect contralateral overstimulation.
Endogenous coalition formation and free trade agreements
Authors: Cao Vi , Fu Haifeng , Henry Wang X. 
Published: August 2024

AbstractThis paper studies the endogenous formation of free trade agreements. There are four countries belonging to two types according to market demand and production technology. A unique strong Nash equilibrium exists for the coalition formation game. In equilibrium, two coalition structures may emerge: global free trade, wherein a single coalition encompassing all countries is established, or polarization, characterized by the formation of two symmetric agreements between the same type countries. The specific coalition structure that emerges in equilibrium depends on both the disparity in demand and the gap in unit cost of production between the two types of countries.
Managerial decisions and team performance: Evidence from professional elite soccer
Authors: Boto‐García David , Bucciol Alessandro , Zarri Luca 
Published: August 2024

AbstractHow do managerial decisions influence team performance? Using tournament data from four sources on 76 managers coaching 34 teams in 1580 matches covering 10 seasons of the Italian male soccer premier league, we provide field evidence on the impact of managerial perseverance in playing style and risk aversion on team performance. We document that managers' perseverance is positively related to team outcomes. Our core findings are robust to a battery of checks. By shedding light on key features of decision‐making in a high‐powered incentives industry with frequent feedback, our results help qualify the “managers matter” view advanced in prior research.
Transverse tensile behavior of carbon fiber/epoxy composite at different temperatures and strain rates
Authors: Wu Qiaoguo , Wu Yuxiang , Zu Lei , Wang Qiankun , Zhang Qian , Zhang Guiming , Fu Jianhui , Zhou Lichuan , Pan Helin 
Published: August 2024

AbstractThis research explores the transverse tensile properties of a unidirectional carbon fiber/epoxy composite under quasi‐static and dynamic conditions, across various temperatures (−30, 25, 85°C). To conduct the investigation, a universal testing machine and a split Hopkinson tensile bar are utilized. The findings reveal that the transverse tensile properties are influenced by temperature and strain rate. At −30, and 25°C, the quasi‐static stress and strain curves exhibit linearity, while at 85, nonlinearity is observed. On the other hand, the dynamic stress and strain curves demonstrate approximate linearity across all temperatures. The quasi‐static tensile strength decreases with rising temperature, but the dynamic tensile strength remains relatively unaffected by temperature variations. Furthermore, both the quasi‐static and dynamic tensile elastic moduli decrease as temperature increases. The transverse tensile strength and elastic modulus exhibit an approximately linear relationship with the logarithm of the strain rate. The study also delves into the analysis of fracture morphologies and mechanisms through macroscopic and microscopic observations. By introducing the dynamic enhancement factor of strain rate, the formulas of the transverse tensile strength and elastic modulus at different temperatures are proposed. These formulas provide a comprehensive representation of the experimental results.Highlights
Tensile properties at different temperatures and strain rates are tested.
Stress and strain curves at various temperatures and strain rates are studied.
Variation of tensile properties with temperature and strain rate is analyzed.
Change of fracture mechanism with temperature and strain rate is discussed.
Formulas for transverse tensile strength and elastic modulus are given.