bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of antioxidant, phenolic profile, melatonin, and volatile compounds of some selected plant samples
Authors: Binici Halil İbrahim , Şat İhsan Güngör , Yilmaz Bilal 
Published: July 2024

AbstractIt was aimed to examine the antioxidant, phenolic profile, and volatile compound contents of seven different aromatic plant samples (broccoli, yarpuz, walnut leaves, marshmallow, wild clary, harmala, and common yarrow) collected from Adilcevaz district of Bitlis province in Türkiye. Gas chromatography–mass spectrometry (GC–MS) device was used for the volatile profile of the plant varieties. The most abundant volatile compounds were generally heptacosane compound that showed anticancer and antimicrobial effects. Piperitone oxide was detected only in yarpuz samples. Phenolic content and antioxidant activity of the plant samples were found to be highly significant (p < .01). When the amounts of total flavonoids were ranked from the largest to the smallest according to plant varieties, it was determined as wild clary > walnut leaves > yarpuz > common yarrow > marshmallow > harmala > broccoli. According to both antioxidant activity methods, wild clary had the lowest IC50 (half‐maximal inhibitory concentration) value, i.e. the highest antioxidant activity. The highest amount of epicatechin was determined in yarpuz (898.30 μg/g) and the lowest amount of epicatechin was determined in wild clary (86.09 μg/g). No epicatechin was detected in the other four plant samples. Among the samples, melatonin hormone was detected only in common yarrow, harmala, and broccoli and the highest value was determined in common yarrow (3996.27 ng/g). Therefore, it shows that plant samples are rich sources of phytochemicals that can play an important role in preventing the progression of many diseases related to oxidative stress in traditional medicine treatment as functional food sources.
Option‐Implied Ambiguity and Equity Return Predictability
Authors: Liu Yanchu , Liu Chen , Chen Yiyao , Sun Xianming 
Published: July 2024

ABSTRACTWe propose a model‐guided option‐implied ambiguity measure to capture uncertainty regarding the return distribution of a risky asset underlying a set of options, and investigate its predictive power on the asset return. A representative investor's ambiguous beliefs or prior distributions on the underlying asset returns are extracted from the market prices of options, the expected volatility of which is then defined as the option‐implied ambiguity and is calculated in line with Brenner and Izhakian. Simulated paths of the calibrated models are utilized to compute all pertinent probability characteristics from a forward‐looking perspective. The empirical results with SSE 50 ETF options indicate that the proposed option‐implied ambiguity has strong predictive power for future returns of SSE 50 ETF. Out‐of‐sample tests also verify the significant predictive ability of the option‐implied ambiguity to the equity returns.
Cerebellum and social abilities: A structural and functional connectivity study in a transdiagnostic sample
Authors: Kong Yue , Roser Mathilde , Bègue Indrit , Elandaloussi Yannis , Neu Nathan , Grigis Antoine , Duchesnay Edouard , Leboyer Marion , Houenou Josselin , Laidi Charles 
Published: July 2024

AbstractThe cerebellum has been involved in social abilities and autism. Given that the cerebellum is connected to the cortex via the cerebello‐thalamo‐cortical loop, the connectivity between the cerebellum and cortical regions involved in social interactions, that is, the right temporo‐parietal junction (rTPJ) has been studied in individuals with autism, who suffer from prototypical deficits in social abilities. However, existing studies with small samples of categorical, case–control comparisons have yielded inconsistent results due to the inherent heterogeneity of autism, suggesting that investigating how clinical dimensions are related to cerebellar–rTPJ functional connectivity might be more relevant. Therefore, our objective was to study the functional connectivity between the cerebellum and rTPJ, focusing on its association with social abilities from a dimensional perspective in a transdiagnostic sample. We analyzed structural magnetic resonance imaging (MRI) and functional MRI (fMRI) scans obtained during naturalistic films watching from a large transdiagnostic dataset, the Healthy Brain Network (HBN), and examined the association between cerebellum–rTPJ functional connectivity and social abilities measured with the social responsiveness scale (SRS). We conducted univariate seed‐to‐voxel analysis, multivariate canonical correlation analysis (CCA), and predictive support vector regression (SVR). We included 1404 subjects in the structural analysis (age: 10.516 ± 3.034, range: 5.822–21.820, 506 females) and 414 subjects in the functional analysis (age: 11.260 ± 3.318 years, range: 6.020–21.820, 161 females). Our CCA model revealed a significant association between cerebellum–rTPJ functional connectivity, full‐scale IQ (FSIQ) and SRS scores. However, this effect was primarily driven by FSIQ as suggested by SVR and univariate seed‐to‐voxel analysis. We also demonstrated the specificity of the rTPJ and the influence of structural anatomy in this association. Our results suggest that there is a complex relationship between cerebellum–rTPJ connectivity, social performance and IQ. This relationship is specific to the cerebellum–rTPJ connectivity, and is largely related to structural anatomy in these two regions.Practitioner Points
We analyzed cerebellum–right temporoparietal junction (rTPJ) connectivity in a pediatric transdiagnostic sample.
We found a complex relationship between cerebellum and rTPJ connectivity, social performance and IQ.
Cerebellum and rTPJ functional connectivity is related to structural anatomy in these two regions.
Survival rates and extra‐regional migration patterns of children and adolescents with cancer in Italy: The 30‐year experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP) with the Italian hospital‐based registry of pediatric cancer (Mod. 1.01)
Authors: Pession Andrea , Quarello Paola , Zecca Marco , Mosso Maria Luisa , Rondelli Roberto , Milani Lorenzo , De Rosa Marisa , Rosso Tiziana , Maule Milena , Fagioli Franca 
Published: July 2024

AbstractSince the 1970s, Italian pediatric oncologists have collaborated through the Italian Association for Pediatric Hematology Oncology (AIEOP) network using a common centralized system for the registration of childhood cancer, known as Model 1.01 (Mod. 1.01). In this study, we report on recruitment trends, extra‐regional migration and changes in outcome over time in the Italian population of children (0–14 years) and adolescents (15–19 years) registered and treated within the national AIEOP network in the period between 1989 and 2017. In almost 30 years, a cohort of 43,564 patients with a neoplasia diagnosis was registered in Mod. 1.01. The analysis of national extra‐regional migration showed that patients tend to migrate from the South to the North and, to a lesser extent, to the Center of the country. During the study period, migration apparently decreased, especially for lymphohematopoietic diseases, whereas it remained substantial for solid tumors. Our data showed a progressive and significant increase in the cumulative survival 5 years after diagnosis since the 1990s, reaching almost 84% for all patients diagnosed in the last decade. Survival rates of Mod. 1.01 patients are similar to those provided by the main national and international reports showing childhood cancer surveillance estimates. The AIEOP Mod 1.01 has proved to be an invaluable tool from both an epidemiological and a health policy point of view, allowing us, in this study, to examine the survival experience of the largest cohort of Italian pediatric cancer patients with a very long follow‐up.
Evaluating recovery capital to promote long‐term recovery for justice‐involved persons in South Florida
Authors: Howard Heather , Skinner‐Osei Precious , Freeman Katherine , Hulick John 
Published: July 2024

AbstractResearchers used a longitudinal design panel to examine the impact of housing stability and peer support on long‐term recovery and recidivism reduction for individuals with justice involvement and substance use histories (N = 97). Using the Recovery Capital Index, bivariate associations were assessed at 90 days for personal capital, rearrest, and housing stability. Of 97 participants, 14 (14%) experienced rearrest and 74 (76%) achieved housing stability. Results showed as social capital increases, personal capital increases (p < 0.0001). This study demonstrates that peer support specialists, care coordination, and building community connections significantly support long‐term recovery and reducing recidivism rates.
Functional characterization of native Piezo1 as calcium and magnesium influx pathway in human myeloid leukemia cells
Authors: Vasileva Valeria Y. , Lysikova Daria V. , Sudarikova Anastasia V. , Khairullina Zuleikha M. , Kirillova Polina I. , Morachevskaya Elena A. , Chubinskiy‐Nadezhdin Vladislav I. 
Published: July 2024

AbstractPiezo1 is a Ca2+‐permeable mechanically activated ion channel that is involved in various physiological processes and cellular responses to mechanical stimuli. The study of biophysical characteristics of Piezo1 is important for understanding the mechanisms of its function and regulation. Stretch activation, a routine approach that is applied to stimulate Piezo1 activity in the plasma membrane, has a number of significant limitations that complicate precise single‐channel analysis. Here, we aimed to determine pore properties of native Piezo1, specifically to examine permeation for physiologically relevant signaling divalent ions (calcium and magnesium) in human myeloid leukemia K562 cells using Piezo1‐specific chemical agonist, Yoda1. Using a combination of low‐noise single‐current patch‐clamp recordings of Piezo1 activity in response to Yoda1, we have determined single‐channel characteristics of native Piezo1 under various ionic conditions. Whole‐cell assay allowed us to directly measure Piezo1 single currents carried by Ca2+ or Mg2+ ions in the absence of other permeable cations in the extracellular solutions; unitary conductance values estimated at various concentrations of Mg2+ revealed strong saturation effect. Patch clamp data complemented with fluorescent imaging clearly evidenced Ca2+ and Mg2+ entry via native Piezo1 channel in human leukemia K562 cells. Mg2+ influx via Piezo1 was detected under quasi‐physiological conditions, thus showing that Piezo1 channels could potentially provide the physiological relevant pathway for Mg2+ ion transport and contribute to the regulation of Mg2+‐dependent intracellular signaling.
Safety, Pharmacokinetics, and Pharmacodynamics of the New Aldose Reductase Inhibitor Govorestat (AT‐007) After a Single and Multiple Doses in Participants in a Phase 1/2 Study
Authors: Perfetti Riccardo , Bailey Evan , Wang Stella , Mills Richard , Mohanlal Ramon , Shendelman Shoshana 
Published: July 2024

AbstractIn classic galactosemia (CG) patients, aldose reductase (AR) converts galactose to galactitol. In a phase 1/2, placebo‐controlled study (NCT04117711), safety, pharmacokinetics (PK), and pharmacodynamics (PD) of govorestat were evaluated after single and multiple ascending doses (0.5‐40 mg/kg) in healthy adults (n = 81) and CG patients (n = 14). Levels of govorestat in plasma and cerebrospinal fluid (CSF) and blood levels of galactitol, galactose, and galactose‐1‐phosphate (Gal‐1p) were measured for population PK and PK/PD analyses. Govorestat was well tolerated. Adverse event frequency was comparable between placebo and govorestat. Govorestat PK displayed a 2‐compartment model with sequential zero‐ and first‐order absorption, and no effect of demographic factors. Multiple‐dose PK of govorestat was linear in the 0.5‐40 mg/kg range, and CSF levels increased dose dependently. Elimination half‐life was ∼10 h. PK/PD modeling supported once‐daily dosing. Change from baseline in galactitol was −15% ± 9% with placebo and −19% ± 10%, −46% ± 4%, and −51% ± 5% with govorestat 5, 20, and 40 mg/kg, respectively, thus was similar for 20 and 40 mg/kg. Govorestat did not affect galactose or Gal‐1p levels. In conclusion, govorestat displayed a favorable safety, PK, and PD profile in humans, and reduced galactitol levels in the same magnitude (∼50%) as in a rat model of CG that demonstrated an efficacy benefit on neurological, behavioral, and ocular outcomes.
A NSC‐34 cell line‐derived spheroid model: Potential and challenges for in vitro evaluation of neurodegeneration
Authors: Arnaldi Pietro , Casarotto Elena , Relucenti Michela , Bellese Grazia , Gagliani Maria Cristina , Crippa Valeria , Castagnola Patrizio , Cortese Katia 
Published: July 2024

AbstractThree‐dimensional (3D) spheroid models aim to bridge the gap between traditional two‐dimensional (2D) cultures and the complex in vivo tissue environment. These models, created by self‐clustering cells to mimic a 3D environment with surrounding extracellular framework, provide a valuable research tool. The NSC‐34 cell line, generated by fusing mouse spinal cord motor neurons and neuroblastoma cells, is essential for studying neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), where abnormal protein accumulation, such as TAR‐DNA‐binding protein 43 (TDP‐43), occurs in affected nerve cells. However, NSC‐34 behavior in a 3D context remains underexplored, and this study represents the first attempt to create a 3D model to determine its suitability for studying pathology. We generated NSC‐34 spheroids using a nonadhesive hydrogel‐based template and characterized them for 6 days. Light microscopy revealed that NSC‐34 cells in 3D maintained high viability, a distinct round shape, and forming stable membrane connections. Scanning electron microscopy identified multiple tunnel‐like structures, while ultrastructural analysis highlighted nuclear bending and mitochondria alterations. Using inducible GFP‐TDP‐43‐expressing NSC‐34 spheroids, we explored whether 3D structure affected TDP‐43 expression, localization, and aggregation. Spheroids displayed nuclear GFP‐TDP‐43 expression, albeit at a reduced level compared with 2D cultures and generated both TDP‐35 fragments and TDP‐43 aggregates. This study sheds light on the distinctive behavior of NSC‐34 in 3D culture, suggesting caution in the use of the 3D model for ALS or TDP‐43 pathologies. Yet, it underscores the spheroids' potential for investigating fundamental cellular mechanisms, cell adaptation in a 3D context, future bioreactor applications, and drug penetration studies.Research Highlights
3D spheroid generation: NSC‐34 spheroids, developed using a hydrogel‐based template, showed high viability and distinct shapes for 6 days.
Structural features: advanced microscopy identified tunnel‐like structures and nuclear and mitochondrial changes in the spheroids.
Protein dynamics: the study observed how 3D structures impact TDP‐43 behavior, with altered expression but similar aggregation patterns to 2D cultures.
Research implications: this study reveals the unique behavior of NSC‐34 in 3D culture, suggests a careful approach to use this model for ALS or TDP‐43 pathologies, and highlights its potential in cellular mechanism research and drug testing applications.
Synthesis of 6‐R‐N‐aryl‐4‐(trichloromethyl)‐4H‐1,3,5‐oxadiazin‐2‐amines based on N‐(2,2,2‐trichloro‐1‐(3‐R‐thioureido)ethyl)carboxamides: Their spectral characteristics and molecular structure
Authors: Lomynoha Yelyzaveta R. , Zadorozhnii Pavlo V. , Kiselev Vadym V. , Kharchenko Aleksandr V. 
Published: July 2024

AbstractIn this work, we report the synthesis of a series of new 4H‐1,3,5‐oxadiazine derivatives. The method of their production is based on the dehydrosulfurization reaction of N‐(2,2,2‐trichloro‐1‐(3‐R‐thioureido)ethyl)carboxamides under the action of a mixture of iodine and triethylamine in DMF. A possible reaction mechanism has been proposed. The target products have been obtained in 58%–75% yield. The structure of the obtained compounds has been confirmed by 1H, 13C NMR, IR spectroscopy data, and x‐ray diffraction analysis carried out for 6‐(tert‐butyl)‐N‐phenyl‐4‐(trichloromethyl)‐4H‐1,3,5‐oxadiazin‐2‐amine.
Programme science methodologies and practices that address “FURRIE” challenges: examples from the field
Authors: Hargreaves James R , Baptiste Solange , Bhattacharjee Parinita , Cowan Frances M , Herce Michael E , Lauer Krista , Sikazwe Izukanji , Geng Elvin 
Published: July 2024

AbstractIntroduction“Programme science” deploys scientific methods to address questions that are a priority to support the impact of public health programmes. As such, programme science responds to the challenges of making such studies: (1) feasible to undertake, (2) useful, (3) rigorous, (4) real‐world‐relevant, (5) informative, and undertaken by (6) equitable partnerships. The acronym “FURRIE” is proposed to describe this set of six challenges. This paper discusses selected HIV/STI (sexually transmitted infection) programme science case studies to illustrate how programme science rises to the FURRIE challenges.DiscussionOne way in which programme science is made more feasible is through the analysis and interpretation of data collected through service delivery. For some questions, these data can be augmented through methods that reach potential clients of services who have not accessed services or been lost to follow‐up. Process evaluation can enhance the usefulness of programme science by studying implementation processes, programme−client interactions and contextual factors. Ensuring rigour by limiting bias and confounding in the real‐world context of programme science studies requires methodological innovation. Striving for scientific rigour can also have the unintended consequence of creating a gap between what happens in a study, and what happens in the “real‐world.” Community‐led monitoring is one approach to grounding data collection in the real‐world experience of clients. Evaluating complex, context‐specific strategies to strengthen health outcomes in a way that is informative for other settings requires clear specification of the intervention packages that are planned and delivered in practice. Programme science provides a model for equitable partnership through co‐leadership between programmes, researchers and the communities they serve.ConclusionsProgramme science addresses the FURRIE challenges, thereby improving programme impact and ultimately health outcomes and health equity. The adoption and adaptation of the types of novel programme science approaches showcased here should be promoted within and beyond the HIV/STI field.
Academic accountability to local communities and society through Programme Science: a case study from the HPV self‐sampling programme HOPE in Peru
Authors: Garcia Patricia Jannet , Santos Carlos , Chiappe Marina , Valderrama María , Carcamo Cesar Paul 
Published: July 2024

AbstractIntroductionHealth challenges in the 21st century underscore the need for adaptable and innovative approaches in public health. Academic institutions can and should contribute much more effectively to generate and translate scientific knowledge that will result in better programmes to improve societal health. Academic accountability to local communities and society requires universities to actively engage with local communities, understanding the context, their needs, and leveraging their knowledge and local experience. The Programme Science initiative provides a framework to optimize the scale, quality and impact of public health programmes, by integrating diverse approaches during the iterative cycle of research and practice within the strategic planning, programme implementation and programme management and evaluation. We illustrate how the Programme Science framework could be a useful tool for academic institutions to accomplish accountability to local communities and society through the experience of Project HOPE in Peru.DiscussionProject HOPE applied the Programme Science framework to introduce HPV self‐sampling into a women's health programme in Peru. Collaboration with local authorities and community members was pivotal in all phases of the project, ensuring interventions aligned with community needs and addressing social determinants of health. The HOPE Ladies—community women trained and empowered to promote and provide the HPV kits—crafted the messages used through the study and developed strategies to reach individuals and provided support to women's journey through health centres. By engaging communities in co‐creating knowledge and addressing health inequities, academic institutions can generate contextually relevant and socially just scientific knowledge. The active participation of community women in Project HOPE was instrumental in improving service utilization and addressing barriers to self‐sampling.ConclusionsThe Programme Science approach offers a pathway for academic institutions to enhance their accountability to communities and society at large. By embedding researchers within public health programmes and prioritizing community engagement, academic institutions can ensure that research findings directly inform policy improvements and programmatic decisions. However, achieving this requires a realignment of research agendas and recognition of the value of community engagement. Establishing Programme Science networks involving academia, government and funding entities can further reinforce academic accountability and enhance the impact of public health programmes.
The resister, the talker and the confessor: A closer look at suspect responses in investigative interviews
Authors: Kelly Christopher E. , Jenaway Elizabeth M. , Kyong‐McClain Akiko , McClary Michael , Meehan Nathan 
Published: July 2024

AbstractResearch on investigative interviewing tends to focus on a limited number of interview methods employed during an interview in pursuit of a singular outcome. The present study took an expansive view of the techniques used, questions asked and interviewer disposition, and related them to three interview goals—overcoming resistance, gathering information and eliciting confessions. Drawing upon theory and prior research, we hypothesised that certain methods would be more relevant to certain outcomes than others, such as question types would have a greater effect on information gain than techniques or interviewer disposition. Using a sample of 43 suspect interviews provided by the Las Vegas Metropolitan Police Department (LVMPD), we found partial support for our hypotheses. Rapport‐based approaches and a respectful disposition reduced resistance, open‐ended questions elicited more information than closed‐ended ones and in the final model, only open‐ended questions increased confessions. Implications for research and practice are discussed.