bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curative Strategy for High-Risk Smoldering Myeloma: Carfilzomib, Lenalidomide, and Dexamethasone (KRd) Followed by Transplant, KRd Consolidation, and Rd Maintenance
Authors: Mateos María-Victoria , Martínez-López Joaquin , Rodriguez Otero Paula , González-Calle Verónica , Gonzalez Marta Sonia , Oriol Albert , Gutiérrez Norma C. , Ríos-Tamayo Rafael , Rosiñol Laura , Alvarez Rivas Miguel Angel , Bargay Joan , Gonzalez-Rodriguez Ana Pilar , Alegre Adrián , Escalante Fernando , Iñigo Rodríguez María Belén , De La Rubia Javier , Teruel Ana Isabel , de Arriba Felipe , Palomera Luis , Hernández Miguel T. , Lopez Jiménez Javier , Reinoso-Segura Marta , García Mateo Aránzazu , Ocio Enrique M. , Paiva Bruno , Puig Noemi , Cedena M. Teresa , Bladé Joan , Lahuerta Juan Jose , San-Miguel Jesus F. ,   on behalf of the Spanish Myeloma Group (GEM-Pethema)
Published: July 2024

PURPOSE Early treatment of high-risk smoldering myeloma has been shown to delay progression to multiple myeloma (MM). We conducted this trial with curative intention using a treatment approach employed for newly diagnosed patients with MM. METHODS Patients with high-risk smoldering myeloma (>50% progression risk at 2 years) and transplant candidates were included and received induction therapy with carfilzomib, lenalidomide, and dexamethasone (KRd), six cycles, followed by high-dose melphalan (200 mg/m2) autologous stem-cell transplantation (HDM-ASCT), two KRd consolidation cycles, and Rd maintenance for 2 years. The primary end point was undetectable measurable residual disease (uMRD) rate by next-generation flow after ASCT. Sustained uMRD 4 years after ASCT was the secondary end point. RESULTS Between June 2015 and June 2017, 90 patients were included, and 31% met at least one SixtyLightchain MRI (SLiM)-hypercalcemia, renal impairment, anemia, bone disease (CRAB) criterion. After a median follow-up of 70.1 months, 3 months after ASCT, in the intention-to-treat population, 56 (62%) of 90 patients had uMRD, and 4 years later, it was sustained in 29 patients (31%). Five patients progressed to MM, and the 70-month progression rate was 94% (95% CI, 84 to 89). The presence of any SLiM CRAB criteria predicted progression to MM (four of the five patients; hazard ratio, 0.12; 95% CI, 0.14 to 1.13; P = .03). Thirty-six patients showed biochemical progression, and failure to achieve uMRD at the end of treatment predicted it. The 70-month overall survival was 92% (95% CI, 82 to 89). Neutropenia and infections were the most frequent adverse events during treatment, resulting in one treatment-related death. Three second primary malignancies have been reported. CONCLUSION Although a longer follow-up is needed, this curative approach is encouraging and more effective than active MM, with 31% of the patients maintaining the uMRD 4 years after HDM-ASCT.
A Propensity-Matched Cohort Study of Intravenous Iron versus Red Cell Transfusions for Preoperative Iron-Deficiency Anemia
Authors: Choi Una E. , Nicholson Ryan C. , Thomas Ananda J. , Crowe Elizabeth P. , Ulatowski John A. , Resar Linda M.S. , Hensley Nadia B. , Frank Steven M. 
Published: July 2024

BACKGROUND:
While preoperative anemia is associated with adverse perioperative outcomes, the benefits of treatment with iron replacement versus red blood cell (RBC) transfusion remain uncertain. We used a national database to establish trends in preoperative iron-deficiency anemia (IDA) treatment and to test the hypothesis that treatment with preoperative iron may be superior to RBC transfusion.

METHODS:
This study is a propensity-matched retrospective cohort analysis from 2003 to 2023 using TriNetX Research Network, which included surgical patients diagnosed with IDA within 3 months preoperatively. After matching for surgery type and comorbidities, we compared a cohort of patients with preoperative IDA who were treated with preoperative intravenous (IV) iron but not RBCs (n = 77,179), with a cohort receiving preoperative RBCs but not IV iron (n = 77,179). Propensity-score matching was performed for age, ethnicity, race, sex, overweight and obesity, type 2 diabetes, hyperlipidemia, essential hypertension, heart failure, chronic ischemic heart disease, neoplasms, hypothyroidism, chronic kidney disease, nicotine dependence, surgery type, and lab values from the day of surgery including ferritin, transferrin, and hemoglobin split into low (<7 g/dL), medium (7–<12 g/dL), and high (≥12 g/dL) to account for anemia severity. The primary outcome was 30-day postoperative mortality with the secondary outcomes being 30-day morbidity, postoperative hemoglobin level, and 30-day postoperative RBC transfusion.

RESULTS:
Compared with RBC transfusion, preoperative IV iron was associated with lower risk of postoperative mortality (n = 2550/77,179 [3.3%] vs n = 4042/77,179 [5.2%]; relative risk [RR], 0.63, 95% confidence interval [CI], 0.60–0.66), and a lower risk of postoperative composite morbidity (n = 14,174/77,179 [18.4%] vs n = 18,632/77,179 [24.1%]; RR, 0.76, 95% CI, 0.75–0.78) (both P = .001 after Bonferroni adjustment). Compared with RBC transfusion, IV iron was also associated with a higher hemoglobin in the 30-day postoperative period (10.1 ± 1.8 g/dL vs 9.4 ± 1.7 g/dL, P = .001 after Bonferroni adjustment) and a reduced incidence of postoperative RBC transfusion (n = 3773/77,179 [4.9%] vs n = 12,629/77,179 [16.4%]; RR, 0.30, 95% CI, 0.29–0.31).

CONCLUSIONS:
In a risk-adjusted analysis, preoperative IDA treatment with IV iron compared to RBC transfusion was associated with a reduction in 30-day postoperative mortality and morbidity, a higher 30-day postoperative hemoglobin level, and reduced postoperative RBC transfusion. This evidence represents a promising opportunity to improve patient outcomes and reduce blood transfusions and their associated risk and costs.
Robotic Spine Surgery: Systematic Review of Common Error Types and Best Practices
Authors: Gautam Diwas , Vivekanandan Sheela , Mazur Marcus D. 
Published: July 2024

BACKGROUND AND OBJECTIVES:
Robotic systems have emerged as a significant advancement in the field of spine surgery. They offer improved accuracy in pedicle screw placement and reduce intraoperative complications, hospital length of stay, blood loss, and radiation exposure. As the use of robotics in spine surgery continues to grow, it becomes imperative to understand common errors and challenges associated with this new and promising technology. Although the reported accuracy of robot-assisted pedicle screw placement is very high, the current literature does not capture near misses or incidental procedural errors that might have been managed during surgery or did not alter treatment of patients. We evaluated errors that occur during robot-assisted pedicle screw insertion and identify best practices to minimize their occurrence.

METHODS:
In this systematic review, we characterized 3 types of errors encountered during robot-assisted pedicle screw insertion—registration errors, skiving, and interference errors—that have been reported in the literature.

RESULTS:
Our search yielded 13 relevant studies reporting robot-assisted screw errors. Nine studies reported registration errors, with 60% of failed screws in those studies caused by registration issues. Seven studies highlighted skiving errors; 26.8% of the failed screws in those studies were caused by skiving. Finally, interference errors were reported in 4 studies, making up 19.5% of failed screws.

CONCLUSION:
On the basis of these findings, we suggest best practices—including close attention to preoperative planning, patient positioning, image registration, and equipment selection—to minimize the occurrence of these errors. Awareness of how errors occur may increase the safety of this technology.
Effects of maternal androgens and their metabolite etiocholanolone on prenatal development in birds
Authors: Wang Yuqi , Riedstra Bernd , Groothuis Ton 
Published: July 2024

ABSTRACT
Offspring phenotypes can be affected by maternal testosterone and androstenedione (A4), which are considered a tool of mothers to adjust offspring to a fluctuating environment. Yet testosterone and A4 are very rapidly metabolized by developing avian embryos, suggesting that either the maternal testosterone and A4 have potent organizational effects on the embryos extremely early before being metabolized or it is the metabolites that evoke phenotypic variation in the offspring. One of the metabolites, etiocholanolone, increases substantially during early embryonic development and is a likely candidate for mediating maternal effects as it can promote erythropoiesis. To investigate and compare the effects of testosterone and A4 with the possible effects of etiocholanolone during prenatal embryonic development, we increased their levels in black-headed gull eggs (Larus ridibundus), and used sham-injected eggs as controls. This species usually has 3-egg clutches in which maternal androgen levels increase with the egg-laying sequence. We analysed embryonic heart rate, peri-hatching biometric traits, the ratio of white to red blood cells (W/R ratio) and bursa development. We found that testosterone and A4 treatment increased embryonic heart rate irrespective of egg-laying sequence and decreased bill length and W/R ratio, whereas etiocholanolone did not mimic these effects. Instead, etiocholanolone treatment decreased tarsus length and brain mass. Our finding that etiocholanolone does not mimic the effects induced by testosterone and A4 suggests that the embryonic metabolism of maternal testosterone and A4 can potentially diversify the function of these maternal androgens.
Mitochondrial functions and fatty acid profiles in fish heart: an insight into physiological limitations linked to thermal tolerance and age
Authors: Chouinard-Boisvert Simon , Ghinter Léopold , St-Pierre Amélie , Mortz Mathieu , Desrosiers Véronique , Dufresne France , Tardif Jean-Claude , Huard Johnny , Sirois Pascal , Fortin Samuel , Blier Pierre U. 
Published: July 2024

ABSTRACT
Heart failure is among the first major consequences of heat stress in aquatic ectotherms. Mitochondria produce most of the ATP used by the heart and represent almost half of the volume in cardiac cells. It has therefore been hypothesized that mitochondrial dysfunction may be a major cause of heart failure associated with heat stress. The present study aims to investigate if CTmax is linked to the thermal sensitivity of cardiac mitochondria in the three-spined stickleback (Gasterosteus aculeatus), and if it is influenced by heart fatty acid composition and age. To do so, we measured the CTmax of 30 fish. The cardiac mitochondrial oxygen consumption was measured by high resolution respirometry at three temperatures and heart lipid profiles were obtained by gas chromatography (GC) coupled with a flame ionization detector (FID). Fish age was estimated via otolith readings. Fatty acid profiles showed no correlation with CTmax, but EPA levels were higher in older individuals. Mitochondrial respiration was measured in 35 fish using high-resolution respirometry. It was strongly affected by temperature and showed a drastic drop in OXPHOS respiration fed by complex I and complex I+complex II, while uncoupled respiration plateaued at CTmax temperature. Our results suggest that complex I is an important modulator of the impact of temperature on mitochondrial respiration at high temperatures but is not the main limiting factor in physiological conditions (maximal OXPHOS). Mitochondrial respiration was also affected by fish age, showing a general decrease in older individuals.
Association between depression and infertility based on the PHQ-9 score: Analyses of NHANES 2013–2018
Authors: Wan Li , He Sijie 
Published: July 2024

Background
Over the past decade, nationally representative research elucidating the association between depression and infertility has been notably lacking. Our study aimed to investigate the association between depression and infertility among women of childbearing age.

Methods
Our study encompassed 3,654 women aged 18 to 45 years from the National Health and Nutrition Examination Survey (NHANES) 2013–2018. Infertility was defined as a positive response to the query: “Have you attempted to conceive for a minimum of one year without achieving pregnancy?” Depression was evaluated by the Patient Health Questionnaire (PHQ-9) score (range, 0–27). Multiple logistic regression analyses and subgroup analyses stratified by age and race/ethnicity were conducted to investigate the association between depression and infertility. Furthermore, fitted smoothing curves and threshold effect analysis were utilized to depict the nonlinear relationship.

Results
Total PHQ-9 score was associated with infertility in the fully adjusted model (OR 1.04, 95% CI 1.01–1.07, P = 0.010), and this relationship exhibited a non-linear pattern, reaching a saturation point at 13, as substantiated by the fitting of smoothed curves. Additionally, the association remained robust when stratified by age but not by race/ethnicity.

Limitations
Cross-sectional design and recall biases.

Conclusions
In this cross-sectional study, depression was associated with infertility among women of childbearing age in the fully adjusted models. This observed association holds potential relevance for clinicians tasked with enhancing psychological well-being during infertility management strategies.
Endurance training volume cannot entirely substitute for the lack of intensity
Authors: Matomäki Pekka , Heinonen Olli J. , Nummela Ari , Kyröläinen Heikki 
Published: July 2024

Purpose
Very low intensity endurance training (LIT) does not seem to improve maximal oxygen uptake. The purpose of the present study was to investigate if very high volume of LIT could compensate the lack of intensity and is LIT affecting differently low and high intensity performances.

Methods
Recreationally active untrained participants (n = 35; 21 females) cycled either LIT (mean training time 6.7 ± 0.7 h / week at 63% of maximal heart rate, n = 16) or high intensity training (HIT) (1.6 ± 0.2 h /week, n = 19) for 10 weeks. Two categories of variables were measured: Low (first lactate threshold, fat oxidation at low intensity exercise, post-exercise recovery) and high (aerobic capacity, second lactate threshold, sprinting power, maximal stroke volume) intensity performance.

Results
Only LIT enhanced pooled low intensity performance (LIT: p = 0.01, ES = 0.49, HIT: p = 0.20, ES = 0.20) and HIT pooled high intensity performance (LIT: p = 0.34, ES = 0.05, HIT: p = 0.007, ES = 0.48).

Conclusions
Overall, very low endurance training intensity cannot fully be compensated by high training volume in adaptations to high intensity performance, but it nevertheless improved low intensity performance. Therefore, the intensity threshold for improving low intensity performance is lower than that for improving high intensity performance. Consequently, evaluating the effectiveness of LIT on endurance performance cannot be solely determined by high intensity performance tests.
Primer reporte Kretzschmaria zonata (Lév.) P.M.D. Martin causando pudrición de la raíz en Tectona grandis L. en Costa Rica
Authors: Rodríguez Solís María , Méndez Álvarez Dawa , Berrocal Jiménez Alexander 
Published: July 2024

Se encontraron árboles enfermos en plantaciones de Tectona grandis en la provincia de Guanacaste, Costa Rica, que mostraban síntomas de pudrición del cuello y la raíz. A nivel morfológico y molecular, se identificó la especie Kretzschmaria zonata como el agente causal de la enfermedad. El micelio del patógeno creció de forma circuncéntrica en un medio PDA, con coloración gris en el centro y blanca en los bordes. Se registraron ascosporas de color café oscuro, cuyo tamaño era (21.6-) 27.4 – 32.1 (-33.5) x (6.2-) 8.7 – 10.9 (-11.8) µm. Las plantas inoculadas con el patógeno presentaron lesiones, con diferencias altamente significativas respecto a las plantas testigo. Se realizaron reaislamientos y se recuperó el hongo K. zonata, cumpliendo con los postulados de Koch. Es la primera vez que se reporta este patógeno causando enfermedad en plantaciones forestales de teca en Costa Rica, lo que constituye un avance para el estudio de estrategias de manejo de la enfermedad.
How to sustain a centralised approach to learning design
Authors: Bearman Margaret , Mahoney Paige , Chandir Harsha , Contessotto Christine , Dunn Matthew , Fox Brandi , McKay Fiona , Taylor Darci 
Published: July 2024

Innovative changes to online teaching practices are becoming increasingly important with the rise of e-learning across the higher education sector. Such innovations ideally become part of teaching repertoires rather than reverting to prior approaches. This study investigated the sustainability of a centralised approach to online learning design. Of the 74 survey respondents, more than 70% described changes to their teaching or work practices, uptake of learning design tools or development of student-facing materials, and these changes were mostly reported as sustained. Changes to system-level supports were less common and less likely to be sustained. Free-text comments highlight the importance of adaptation, collaboration and iteratively developed learning design templates. These provide guidance on how to promote sustained changes to online teaching practice.

Implications for practice or policy:

Outcomes for sustained changes to online teaching practice can be improved through innovations that are adaptable and collaborative and build educator capability.
Learning design templates and resources can guide educators to develop their online teaching practice while allowing flexible and iterative implementation.
Sustained changes to online teaching practices may be impeded by aging student-facing materials, withdrawal of support and unfeasible workloads.
A novel design of a Wilkinson power divider based on the circular-shape resonator
Authors: El Bouslemti Rahmouna , Farah Chemseddine M. 
Published: July 2024

Abstract
This paper describes the general properties of power dividers, in particular matching and isolation. This original works relates to three different divider structures based on the circular-shaped resonator. These prototypes resemble the Wilkinson power divider due to their geometric configuration. These power dividers provide very good isolation between their output ports of −51.26 dB. In fact, the originality of these new structures stems from the idea of minimizing the size of this classic power divider. The required design parameters for the three proposed dividers came from a simulation study using the Ansoft HFSS tool in addition to a design theory. The experimental prototypes are well presented and operate at 2.4 GHz. They demonstrate excellent performance in adaptation, which refers to impedance matching, ensuring consistent impedance at the component terminations. Additionally, they exhibit low insertion losses and high isolation at 2.4 GHz. The measurement results agree well with those of the simulation. The benefits demonstrated by this study are significant, justifying the preference for these components.
Bidirectional triple-band truly incident angle insensitive polarization converter using graphene-based transmissive metasurface for terahertz frequency
Authors: Mistri Hiranmay , Ghosh Anumoy , Dandapathak Manaj 
Published: July 2024

Abstract
The design and response of a triple-band linear-to-circular polarization converter (LTCPC) in the terahertz frequency regime using a graphene-based transmission-type metasurface have been studied numerically and analytically. The unit cell of the converter is constructed using lossy silicon dioxide (SiO2) with a relative permittivity of 3.9 as the substrate. And two similar layers of graphene-based sub-wavelength structures are used at the top and bottom of it. Multiband linear to circular polarization conversion is achieved from 0.74 THz to 0.98 THz, 1.70 THz to 2.33 THz, and 4.06 THz to 5.19 THz, i.e., about 28 %, 31 %, and 24 % fractional bandwidths, respectively. As the same metasurface configuration is used at the top and bottom layers of the transmission-type unit cell, it can be used as a bidirectional polarization converter with identical responses from both sides. The geometrical optimization of the unit cell is done, and an equivalent lumped parameter circuit model is also proposed for the same, considering analogous responses. Tunability over the operating frequency is achieved by varying the chemical potential and relaxation time of graphene. Moreover, due to the ultrathin width and special types of identical configuration of the metasurfaces, the response of the system remains excellent over a wide range of incident angle variations up to 80° angle of incidence.
The names of the Dusky Striped Squirrel (Funambulus obscurus, Sciuridae) and Kathleen Ryley in the Bombay Natural History Society’s Mammal Survey
Authors: Dissanayake Rajith , Zijlstra Jelle S. , Darwich Martina 
Published: July 2024

Abstract
We review the history of the Sri Lankan squirrel Funambulus obscurus in the context of the Bombay Natural History Society’s Mammal Survey of South Asia. Kathleen Ryley (1883–1935), who helped to compile the results of the Survey, was among the earliest women to name a species of mammal. She was the first to recognise the Sri Lankan species as distinct from its closest relative in southern India. This decision has been confirmed by recent research, but her chosen name for the species is no longer considered valid. We record the rediscovery of the holotype specimen of F. obscurus in Vienna, confirming its identity. We suggest the common name “Dusky Striped Squirrel” for the Sri Lankan F. obscurus and “Pygmy Striped Squirrel” for the Indian Funambulus sublineatus.
Existence and properties of soliton solution for the quasilinear Schrödinger system
Authors: Zhang Xue , Zhang Jing 
Published: July 2024

Abstract
In this article, we consider the following quasilinear Schrödinger system:

−
ε
Δ
u
+
u
+

k

2

ε

[

Δ

∣
u
∣

2

]

u
=

2
α

α
+
β

∣
u
∣

α
−
2

u

∣
v
∣

β

,

x
∈

R

N

,

−
ε
Δ
v
+
v
+

k

2

ε

[

Δ

∣
v
∣

2

]

v
=

2
β

α
+
β

∣
u
∣

α

∣
v
∣

β
−
2

v
,

x
∈

R

N

,

\left\{\begin{array}{ll}-\varepsilon \Delta u+u+\frac{k}{2}\varepsilon \left[\Delta \hspace{-0.25em}{| u| }^{2}]u=\frac{2\alpha }{\alpha +\beta }{| u| }^{\alpha -2}u{| v| }^{\beta },& x\in {{\mathbb{R}}}^{N},\\ -\varepsilon \Delta v+v+\frac{k}{2}\varepsilon \left[\Delta \hspace{-0.25em}{| v| }^{2}]v=\frac{2\beta }{\alpha +\beta }{| u| }^{\alpha }{| v| }^{\beta -2}v,& x\in {{\mathbb{R}}}^{N},\end{array}\right.

where

ε
>
0
,
k
<
0

\varepsilon \gt 0,k\lt 0

are real constants,

N
≥
3

N\ge 3

,

α
,
β

\alpha ,\beta

are integers multiple of constant 2. By using the Mountain Pass Theorem in a suitable Orlicz space proposed by Abbas Moameni [Existence of soliton solutions for a quasilinear Schrödinger equation involving critical exponent in

R

N

{{\mathbb{R}}}^{N}

, J. Differential Equations 229 (2006), 570–587], we proved the existence of soliton solution

(

u

ε

,

v

ε

)

\left({u}_{\varepsilon },{v}_{\varepsilon })

for the above system, and

(

u

ε

(

x

)

,

v

ε

(

x

)

)

→

(

0
,
0

)

({u}_{\varepsilon }\left(x),{v}_{\varepsilon }\left(x))\to \left(0,0)

as

∣
ε
∣
→
0

| \varepsilon | \to 0

.
Crystal structure of poly[(μ4-(3-amino-1H-1,2,4-triazol-1-yl)benzene-1,3-dicarboxylato-κ
4

N:O:O':O')(1-methylpyrroldin-2-one-κ1O)dicopper(II)] – 1-methylpyrroldin-2-one (1/3), C40H48Cu2N12O12
Authors: Xia Yu-Pei , Huang Yu-Xin 
Published: July 2024

Abstract
C40H48Cu2N12O12, monoclinic, P21/n (no. 14), a = 10.9519(1) Å, b = 17.4351(2) Å, c = 24.4288(3) Å, β = 102.143(1)°, V = 4560.25(9) Å3, Z = 4, Rgt
(F) = 0.0647, wRref
(F
2) = 0.1904, T = 120 K.
Crystal structure of (3,6-di(2-pyridyl)-4-methylphenyl pyridazine-k
2
N,N′)-bis(1-phenyl-pyrazole-κ
2
C,N) iridium(III) hexafluorophosphate, C39H29F6IrN8P
Authors: Qian Jun , Ma Liang , Wang Yida 
Published: July 2024

Abstract
C39H29F6IrN8P, orthorhombic, Pbca (no. 61), a = 19.6205(7) Å, b = 16.2026(6) Å, c = 23.0700(8) Å, V = 7334.0(5) Å3, Z = 8, R

gt
(F) = 0.0258, wR

ref
(F
2) = 0.0611, T = 293 K.