bluuebunny/crossref_metadata_2025_split huggingface dataset:
13C-enriched carbonate precipitates reveal intense methanogenic oil degradation in the upper Wuerhe Formation, Northwest China
Authors: Liu Wendong , Hu Wenxuan , Zhang Wenjie , Wang Xiaolin , Cao Jian , Luo Xianglong , An Shichao , Li Wenwen , Zhi Dongming , Li Weiqiang 
Published: August 2024

Abstract
Microbial methanogenesis from crude oil is an important source of CH4 for gas reservoirs and atmospheric greenhouse gases. However, its petrological records have not been found in natural environments, and the geological conditions under which it may occur remain unclear. Here, we provide the first petrological evidence of Fe(III)-mediated methanogenic hydrocarbon degradation in a deep subsurface oil reservoir in Northwest China. The major findings are as follows: (1) highly positive δ13C values (up to +16‰) of secondary calcite attributed to methanogenesis; (2) paragenetic relation of high-δ13C calcite to biodegraded hydrocarbon; and (3) remarkably high FeO contents (up to 8 wt%) and heavy δ56Fe ratios (up to +0.52‰) in calcite, indicative of microbial Fe(III) reduction. Our study shows that methanogenic hydrocarbon degradation can occur in Fe(III)-reducing environments. This process transformed hydrocarbons into CO2 and CH4, where the former mostly precipitated as Fe-rich calcite (the carbon sink), while the latter, representing an estimated ~1968 Tg, might have escaped into the overburden and atmosphere from the Permian reservoir during the Late Triassic to Early Jurassic, which may have acted as an important CH4 source in changing global climate in the geological past.
Assessing the 3D resolution of refocused correlation plenoptic images using a general-purpose image quality estimator
Authors: Massaro Gianlorenzo 
Published: August 2024

AbstractCorrelation plenoptic imaging (CPI) is emerging as a promising approach to light-field imaging (LFI), a technique enabling simultaneous measurement of light intensity distribution and propagation direction from a scene. LFI allows single-shot 3D sampling, offering fast 3D reconstruction for a wide range of applications. However, the array of micro-lenses typically used in LFI to obtain 3D information limits image resolution, which rapidly declines with enhanced volumetric reconstruction capabilities. CPI addresses this limitation by decoupling the measurement of the light field on two photodetectors with spatial resolution, eliminating the need for micro-lenses. 3D information is encoded in a four-dimensional correlation function, which is decoded in post-processing to reconstruct images without the resolution loss seen in conventional LFI. This paper evaluates the tomographic performance of CPI, demonstrating that the refocusing reconstruction method provides axial sectioning capabilities comparable to conventional imaging systems. A general-purpose analytical approach based on image fidelity is proposed to quantitatively study axial and lateral resolution. The analysis fully characterizes the volumetric resolution of any CPI architecture, offering a comprehensive evaluation of its imaging performance.
Removal of Subinternal Limiting Membrane Hemorrhage Secondary to Valsalva Retinopathy Using a Fovea‐Sparing Internal Limiting Membrane Fissure Creation Technique
Authors: Sotani Yasuyuki , Imai Hisanori , Kishi Maya , Yamada Hiroko , Matsumiya Wataru , Miki Akiko , Kusuhara Sentaro , Nakamura Makoto 
Published: August 2024

Introduction: Valsalva retinopathy can cause submacular hemorrhage (SMH), which may lead to visual disturbances. SMH can extend into the subinternal limiting membrane (ILM) and vitreous spaces, sometimes occurring concomitantly with full‐thickness macular holes (FTMHs). Herein, we describe a case in which sub‐ILM hemorrhage was removed without peeling the ILM of the central fovea, thus preserving the foveal ILM.Case Presentation: A 48‐year‐old female patient developed rapid‐onset bilateral visual impairment due to SMH secondary to Valsalva retinopathy. The SMH predominantly consisted of sub‐ILM hemorrhage. However, detailed observation was challenging due to the dense sub‐ILM hemorrhage in the left eye. Initial best‐corrected visual acuity (BCVA) in the right and left eyes were 1.2 and 0.03, respectively. Intravitreal tissue plasminogen activator (tPA) and sulfur hexafluoride (SF6) gas injections were initially administered to displace the SMH in the left eye; however, the SMH could not be successfully displaced. A vitrectomy was then performed. Intraoperatively, an ILM fissure beyond the foveal region was created using ILM forceps. The balanced salt solution was sprayed onto the ILM, and the sub‐ILM hemorrhage was drained into the vitreous cavity from the ILM fissure. The surgery successfully displaced the sub‐ILM hemorrhage while preserving the foveal ILM. No postoperative complications were observed. Visual acuity remained at 1.2 in the right eye and improved to 1.2 in the left eye 6 months postoperatively.Conclusion: Removing foveal sub‐ILM hemorrhage without peeling the foveal ILM can be a viable treatment option to preserve the foveal ILM.
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression
Authors: Kobayashi Hiroki , Iida Tadashi , Ochiai Yosuke , Malagola Ermanno , Zhi Xiaofei , White Ruth A. , Qian Jin , Wu Feijing , Waterbury Quin T. , Tu Ruhong , Zheng Biyun , LaBella Jonathan S. , Zamechek Leah B. , Ogura Atsushi , Woods Susan L. , Worthley Daniel L. , Enomoto Atsushi , Wang Timothy C. 
Published: August 2024

Abstract
Cancer-associated fibroblasts (CAF) and nerves, components of the tumor microenvironment, have each been shown to directly promote gastrointestinal cancers. However, it remains unknown whether these cells interact with each other to regulate cancer progression. We found that in colorectal cancer, norepinephrine induces ADRB2 (β2-adrenergic receptor)–dependent nerve growth factor (NGF) secretion from CAFs, which in turn increases intratumor sympathetic innervation and norepinephrine accumulation. Adrenergic stimulation accelerates colorectal cancer growth through ADRA2A/Gi-mediated activation of Yes-associated protein (YAP). NGF from CAFs directly enhances colorectal cancer cell growth via the phosphatidylinositol-3-kinase/AKT pathway. Treatment with a tropomyosin receptor kinase (TRK) inhibitor decreased YAP and AKT activation and colorectal cancer progression in mice. In human colorectal cancer, high NGF expression is associated with mesenchymal-like tumor subtype and poor patient survival. These findings suggest a central role for reciprocal CAF–nerve cross-talk in promoting colorectal cancer progression. Blocking this feedforward loop with a TRK inhibitor may represent a potential therapeutic approach for colorectal cancer.

Significance:
Our work demonstrates that the bidirectional interplay between sympathetic nerves and NGF-expressing CAFs drives colorectal tumorigenesis. This study also offers novel mechanistic insights into catecholamine action in colorectal cancer. Inhibiting the neuro-mesenchymal interaction by TRK blockade could be a potential strategy for treating colorectal cancer.
Burden of Heart Failure in Patients With Tricuspid Regurgitation and Effect of Transcatheter Repair on Different Subdimensions of Quality of Life
Authors: Stocker Thomas J. , Sommer Saskia , Cohen David J. , Spertus John A. , Stolz Lukas , Doldi Philipp M. , Weckbach Ludwig T. , Nabauer Michael , Massberg Steffen , Hausleiter Jörg 
Published: August 2024

Background
Right‐sided heart failure (HF) due to severe tricuspid regurgitation (TR) is associated with reduced quality of life (QoL). Here, we analyzed the impact of TR on specific QoL dimensions and the effect of transcatheter tricuspid valve intervention (TTVI) on individual QoL items.

Methods and Results

In this study, we included 174 patients with HF (49% women; median age, 79 years; 97% New York Heart Association ≥3) with baseline QoL assessment undergoing TTVI by transcatheter edge‐to‐edge‐repair at our center between April 2016 and March 2022. QoL was assessed by the standardized Minnesota Living With HF Questionnaire. QoL change after TTVI and correlation to functional end points were analyzed. In addition, all QoL domains and the 21 individual items of the Minnesota Living With HF Questionnaire were analyzed. TTVI significantly reduced TR (TR ≥3: baseline 95%, 1‐year‐follow‐up 7%;
P
<0.001). Total Minnesota Living with HF Questionnaire score improved from 37 (interquartile range, 26–50) points to 31 (interquartile range, 17–42) points (median follow‐up‐interval, 355 days;
P
<0.001). QoL improvement was associated with positive New York Heart Association class, 6‐minute walking distance, and actigraphy changes (all
P
<0.05). The detailed analysis revealed that all items of the physical‐related QoL dimension were impaired at baseline and strongly improved after TTVI. In contrast, the emotional and “social” Minnesota Living With HF Questionnaire dimensions were largely unaffected at baseline, yet specific items improved with TTVI.

Conclusions
In this single‐center study, we delineate the QoL‐associated disease burden of TR and identify specific QoL items that improved after TTVI. Our findings support TTVI in patients with reduced QoL and may add to the development of specific tools assessing the functional status of an increasing patient population undergoing TTVI.
Distinct neural networks of task engagement and choice response in moral, risky, and ambiguous decision-making: An ALE meta-analysis
Authors: Ambrase Aiste , Müller Veronika I. , Camilleri Julia A. , Wong Hong Yu , Derntl Birgit 
Published: August 2024

Abstract
Moral, risky, and ambiguous decision-making are likely to be characterized by common and distinct cognitive processes and thus show partly overlapping neural correlates. Previously, two different analysis approaches have been used to assess the neural correlates in all three domains: (a) comparing general engagement in an experimental task versus a control task (task engagement) or (b) comparing actual opposite choices made during the experimental task (choice response). Several coordinate-based activation likelihood estimation meta-analyses were performed to delineate consistent activations across experiments of the two analysis categories and the different decision-making domains. Our results show that task engagement and choice response capture different aspects of salience network involvement and reward-related striatum processing during decision-making. When assessing domains separately, we discovered that moral cues are processed in a multi-modal social cognition network, while risk and ambiguity require engagement of the salience and the frontoparietal attention networks. This is the first meta-analysis to disentangle the two analysis approaches yielding new insight into common and distinct neural correlates of different kinds of decision-making.
Numerical discrimination in domestic horses: a spontaneous binary choice test
Authors: Balestrieri Alessandro , Corona Silvia , Gazzola Andrea , Romano Andrea 
Published: August 2024

Abstract
While domestic horses can be trained to choose the highest numerosity, spontaneous choice tests led to contrasting results, which in part might have depended upon the adopted experimental protocols. To bring further evidence, we carried out two experiments based on binary choice tests (1:4, 1:2, 2:3, 4:6 apple halves). We tested both horses used for schooling () and semi-wild bred horses (), using two different arenas. In both experiments, horses did not choose the highest quantity, irrespective of test difficulty. Horses preferentially chose the stimulus located at their left, while no other tested variable affected their choice. The consistency between the results suggests that the lack of discrimination did not depend on test protocols. The strong preference for a given side and high within-individual repeatability indicate that lateralization may affect the results of spontaneous tests.
Family Business Challenges and their Regulations under UAE Family Business Law
Authors: Saad Myrna 
Published: August 2024

Abstract
The United Arab Emirates (UAE) has created a unique, comprehensive, and flexible legal framework for regulating the ownership and governance of family companies. This article examines how Federal Decree-Law No. 37 of 2022 on family businesses (the Family Business Law) addresses the main challenges faced by these companies. The article begins with an overview of the various definitions of family businesses, followed by a description of the definition adopted by the Family Business Law. The article then explores how the new law helps family businesses navigate the complexities of growth while preserving family control and the family’s long-term vision. The article further discusses the challenges associated with business continuity and analyses how the Family Business Law establishes robust corporate governance measures to support their long-term continuity and facilitate their transfer across generations.
The Social Distribution of Public Debt in Portugal, 1529–1680
Authors: Miranda Susana Münch , Rodrigues Lisbeth , Lopes Bruno 
Published: August 2024

Abstract
This article examines the social distribution of public debt in Portugal between 1529–57 and 1641–82 and explores the extent to which the Portuguese debt system relied on personal relationships. A newly compiled dataset on the socioeconomic characteristics of lenders reveals a shift over time: from an elite group consisting of nobles and royal officials to a broader social base in the mid-seventeenth century when institutions and merchants entered the market. The data show that the changing social distribution of Portuguese public debt is the result of interest rate reduction operations and a fund-raising campaign, the latter of which involved some degree of financial repression.
Portuguese Public Finances in the Golden Age, 1950–1973: an Illustrated Overview
Authors: Ferraz Ricardo 
Published: August 2024

Abstract
The aim of this paper is to analyse the Portuguese public finances during the Golden Age of the world economy (1950–1973). The results obtained show that during most of this period, Portugal registered budgetary deficits, although none exceeded 3% of GDP, with the public debt/GDP ratio remaining below 25%, which appears to imply that Portuguese finances were sound. Additionally, and from an international perspective, it was also possible to conclude that Portugal was integrated in a restricted group of five European countries that simultaneously presented average values for deficit and debt that did not exceed 1% and 20% of GDP, respectively.
From Macau to Goa and Mozambique: Oyster Windows in Indo-Portuguese Architecture
Authors: Carita Helder 
Published: August 2024

Abstract
Substituting glass with small plaques [plaquettes] of mother-of-pearls, the carepa windows (oyster windows) – as they are called in Goa – constitute a very well-recognized signature of Goan architecture. The great variety of formal variations, the fine and delicate design, as well as their marked exoticism, make them a characteristic identitarian feature of Indo-Portuguese architecture. This essay seeks to explain the origins and the multiple manifestations of this manufacturing process and product: not only in Goa, but also in other territories of the Estado da India, as well as in faraway lands in southern China and the Philippine Islands. Through a wide range of examples and a broad perspective, we intend to reconstruct the circulation of this formal solution which, originated in Southern China and in the region of Guangdong, will transit through Macau and the Philippines, as much as multiple territories of the Luso-phone world, such as Baçaim, Damão and Mozambique in Africa. By assembling a preliminary catalogue and data bank for the study of this architectural and decorative phenomenon, we will offer some answers on its formal evolution through time and typologies.
Systematic Literature Review of the Research Design Based on the Tafsir Tahliliy Method
Authors: Zainudin Siti Aishah , Hassan Shahir Akram 
Published: August 2024

Abstract
There is an initiative to build a study design based on Islamic principles. However, there is yet to be a study that has systematically reviewed the literature pertaining to an Islamic study design based Tahliliy interpretation method (TIM). A systematic literature review (SLR) would provide a more specific picture of related publications. Hence, what elements of the Tahliliy interpretation method (TIM) can be applied in a study design? To answer this question, this study was guided by the PRISMA publication standards and used three databases, namely Google Scholar, Academia and ResearchGate, to search for articles published from 2011 to 2020. A total of 105 reference materials that used the keywords “research design” and “Tafsir Tahliliy” (TIM) were found, but only 10 were analysed after passing the screening process. The discussion was divided into three themes, namely Islamic-based research methods, study design and Tafsir Tahliliy (TIM). All three themes showed that is relevant for the TIM to be used as a study design in Islamic research; therefore, it is also this study’s suggestion that the TIM should be adopted as a research design in Islamic-based research methods.
Nonlinear Radiative Response to Patterned Global Warming due to Convection Aggregation and Nonlinear Tropical Dynamics
Authors: Quan Heng , Zhang Bosong , Wang Chenggong , Fueglistaler Stephan 
Published: August 2024

Abstract
Climate responses to global warming exhibit large dependence on the spatial pattern of sea surface temperature (SST) changes. A Green’s function (GF) approach—predicting the global climate response to a complex SST pattern change as the linear superposition of the response to finite-area SST perturbations evaluated in isolation—has been used to systematically evaluate and understand the top of atmosphere (TOA) radiation response to patterned warming. However, in general, the linear GF approach fails for TOA radiation reconstruction under future global warming scenarios in coupled models. Here, we show that the linear superposition of global mean TOA radiation responses to large SST warming perturbations at multiple patches (the GF approach prediction) overestimates the actual response to simultaneous multipatch perturbation. This is because the linear superposition overestimates tropical large-scale convection aggregation strengthening upon localized heating that enhances longwave radiative cooling, which is further explained by the overestimation of circulation response and associated horizontal water vapor transport. The nonadditivity of TOA radiation response is caused by the nonadditivity of convection aggregation, ultimately rooted in nonlinear tropical dynamics. We also demonstrate that the prediction error of the GF approach grows with decreasing patch size (equivalently, increasing patch number). We conclude that using the GF approach to predict future climate change could overestimate longwave radiative cooling and underestimate (effective) climate sensitivity. Numerical experiments may be used to identify specific perturbation patterns where the errors are smaller than the signal. Our research also highlights that an increase in the degree of large-scale convection aggregation has a nonlinear and negative feedback for mean warming.
Development and validation of the Unmet Needs Questionnaire for young stroke survivors
Authors: Kuo Wen-Yu , Chen Chen-Yin , Chang Ting-Yu , Wang Jeng , Wang Chin-Man , Tsay Pei-Kwei 
Published: August 2024

Objective Owing to the lack of a suitable tool for detecting the unmet needs of young stroke survivors, this study aims to develop a validated questionnaire for evaluating these unmet needs. Design A cross-sectional, observational research design. Setting Chang Gung Memorial Hospital Linkou and Taoyuan branches in Taiwan. Participants A total of 211 participants (average age 53 years; within 6 months post-stroke) completed the questionnaire. Main measures A qualitative approach was used to create an item pool. Experts verified item suitability, and content validity was evaluated using the item content validity index. Item analysis was applied to determine item quality, and factor analysis was used to explore construct validity. In addition, parallel analysis was employed to ascertain the optimal number of factors. Results The scale development procedure resulted in a 27-item questionnaire that assesses the unmet needs of young stroke survivors after a stroke. The item content validity index was 1.0. The Unmet Needs Questionnaire has five factors: restoring prestroke abilities and life, rehabilitation-related resources, social support and self-adjustment, economic and post-stroke life adjustment, and stroke-related information. These five factors accounted for 54% of the variance. Cronbach's alpha for the total scale was 0.91, while the alpha for the subscales ranged from 0.74 to 0.88. Conclusions The Unmet Needs Questionnaire showed acceptable reliability and validity. It can help clinical professionals and government agencies identify stroke survivors’ unmet needs and develop tailored care plans. Future research should explore the trajectory of post-stroke unmet needs using this tool.
Effects of high tibial osteotomy on the coronal, sagittal, and axial alignments of the ankle joint
Authors: Oh Byung Hak , Seo Kyung Deok , Yoo Hyun Jin , Jang Min Gu , Park Ji Seong , Song Jae Hwang 
Published: August 2024

Background No comprehensive study has been conducted on the effects of high tibial osteotomy (HTO) on the coronal, sagittal, and axial alignments of the ankle joint. Therefore, this study aimed to investigate the multiplane changes in the ankle joint following HTO using the EOS biplanar X-ray imaging system. Methods The medical records of 43 patients who underwent HTO for the treatment of medial knee osteoarthritis were retrospectively reviewed. Preoperative and postoperative EOS images and lower-extremity scanograms were evaluated; the correlations between the outcomes were evaluated. Results After HTO, the ankle joint axis point on the weight-bearing line showed significant lateralization ( p < .001). The knee lateral ankle surface angle increased significantly in the sagittal alignment ( p < .001). The distal tibia showed a significant internal rotation in the axial plane ( p = .022). Tibial rotation showed no significant relationship with the other parameters. Conclusions HTO induced lateralization of the ankle joint axis (coronal), increased the posterior tibial slope (sagittal), and caused the internal rotation of the distal tibia (axial). Axial changes in the distal tibia showed no significant relationship with other coronal and sagittal parameters of the ankle joint. We suggest that surgeons should consider, during HTO, that the ankle joint axis shifts laterally and distal tibia has tendency to rotate internally after HTO.