bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of electronic diabetes registry ‘Meaningful Use’ on quality of care and hospital utilization
Authors: Han Wencui , Sharman Raj , Heider Arvela , Maloney Nancy , Yang Min , Singh Ranjit 
Published: July 2015

Abstract
Objective To investigate whether the use of diabetes registries meeting Meaningful Use core objectives in primary care practices is associated with differences in quality of care and hospital utilization rates.
Materials and methods A practice assessment survey was conducted to identify whether and how practices were using diabetes registries. Insurance claims data from 2010 were used to compare the health outcomes of patients from practices that used diabetes registries meeting Meaningful Use–related objectives to the outcomes of patients from other practices. Logistic hierarchical linear modeling was used to analyze the data.
Results Records from 12,514 diabetic patients (including 10 809 with type 2 diabetes) from 50 urban practices were included in the analysis. The results suggest that patients with type 2 diabetes who were treated in practices using registries for patient reminders were more likely to have completed the recommended laboratory testing (odds ratio [OR] 1.26, p &lt; 0.01) and dilated retinal examinations (OR 1.14, p &lt; 0.01). Patients in practices using registries for quality improvement were less likely to have ‘avoidable hospitalization’ (OR 0.83, p &lt; 0.01) and emergency room visits (OR 0.76, p &lt; 0.01). The use of a diabetes registry did not have a significant impact on the quality of care or hospital utilization for patients with type 1 diabetes.
Conclusion Use of diabetes registries meeting Meaningful Use core objectives is associated with higher completion or recommended lab tests and a lower hospital utilization rate for patients with type 2 diabetes.
Tim O'Brien
Authors: Calloway Catherine 
Published: July 2015

Tim O’Brien (b. 1946) is a well-known contemporary American writer of seven novels, one memoir, and numerous short stories, nonfiction essays, and reviews. He has been a regular contributor to The New Yorker, The Atlantic, and Esquire, and selections from The Things They Carried and other works are frequently anthologized in textbooks and short-story collections, including The Best American Short Stories of the Century. One of three children, O’Brien lived in his birth town of Austin, Minnesota, until the age of ten when his family relocated to Worthington, Minnesota. After a public school education, he graduated from Macalaster College in Saint Paul, Minnesota, summa cum laude with a degree in political science. Shortly after graduation, his plans for graduate school were interrupted by the Vietnam War. The United States Army drafted O’Brien, and he served in Quang Ngai Province in Vietnam in 1969 and 1970. Upon his discharge from the military, O’Brien enrolled in graduate school at Harvard University, planning to study government, and worked briefly as a reporter for the Washington Post. When the short sketches that O’Brien published in magazines and newspapers while in Vietnam led to the publication of If I Die in A Combat Zone in 1973, O’Brien began a full-time writing career and left graduate school. His reputation was established in 1979 when he received the National Book Award for his second novel, Going After Cacciato (1978). In addition to that novel, his best-known work includes The Things They Carried (1990), which received the Chicago Tribune Heartland Award for fiction and France’s Prix du Meilleur Livre Estranger and was a finalist for the Pulitzer Prize, and In the Lake of the Woods (1994), which received the novel of the year award from Time magazine and the Society of American Historians’ James Fenimore Cooper Prize for outstanding historical novel. O’Brien has also received the National Magazine Award and the Katherine Anne Porter Award, as well as numerous other accolades. In 2012 he received the Dayton Literary Peace Prize Foundation’s Richard C. Holbrooke Distinguished Achievement Award, and in 2013 he had the distinction of becoming the first fiction writer to receive The Pritzker Literature Award for Lifetime Achievement in Military Writing. O’Brien is well known for blurring the boundaries between fiction and fact and for debating the issue of relative truth in his work while treating such universal subjects as love, death, the imagination, memory, the art of writing, aging, and war. While the topic of Vietnam emerges in all of O’Brien’s major works, he does not consider himself a war writer per se. Since 1999, O’Brien has taught at Texas State University at San Marcos where he holds the Roy F. and Joann Cole Mitte Chair in Creative Writing. He continues to give readings and talks around the country.
Epidemiologic Investigation of a Cluster of Neuroinvasive Bacillus cereus Infections in 5 Patients With Acute Myelogenous Leukemia
Authors: Rhee Chanu , Klompas Michael , Tamburini Fiona B. , Fremin Brayon J. , Chea Nora , Epstein Lauren , Halpin Alison Laufer , Guh Alice , Gallen Rachel , Coulliette Angela , Gee Jay , Hsieh Candace , Desjardins Christopher A. , Pedamullu Chandra Sekhar , DeAngelo Daniel J. , Manzo Veronica E. , Folkerth Rebecca Dunn , Milner Danny A. , Pecora Nicole , Osborne Matthew , Chalifoux-Judge Diane , Bhatt Ami S. , Yokoe Deborah S. 
Published: July 2015

Abstract
Background.  Five neuroinvasive Bacillus cereus infections (4 fatal) occurred in hospitalized patients with acute myelogenous leukemia (AML) during a 9-month period, prompting an investigation by infection control and public health officials.
Methods.  Medical records of case-patients were reviewed and a matched case-control study was performed. Infection control practices were observed. Multiple environmental, food, and medication samples common to AML patients were cultured. Multilocus sequence typing was performed for case and environmental B cereus isolates.
Results.  All 5 case-patients received chemotherapy and had early-onset neutropenic fevers that resolved with empiric antibiotics. Fever recurred at a median of 17 days (range, 9–20) with headaches and abrupt neurological deterioration. Case-patients had B cereus identified in central nervous system (CNS) samples by (1) polymerase chain reaction or culture or (2) bacilli seen on CNS pathology stains with high-grade B cereus bacteremia. Two case-patients also had colonic ulcers with abundant bacilli on autopsy. No infection control breaches were observed. On case-control analysis, bananas were the only significant exposure shared by all 5 case-patients (odds ratio, 9.3; P = .04). Five environmental or food isolates tested positive for B cereus, including a homogenized banana peel isolate and the shelf of a kitchen cart where bananas were stored. Multilocus sequence typing confirmed that all case and environmental strains were genetically distinct. Multilocus sequence typing-based phylogenetic analysis revealed that the organisms clustered in 2 separate clades.
Conclusions.  The investigation of this neuroinvasive B cereus cluster did not identify a single point source but was suggestive of a possible dietary exposure. Our experience underscores the potential virulence of B cereus in immunocompromised hosts.
The anatomical distribution of genetic associations
Authors: Wells Alan , Kopp Nathan , Xu Xiaoxiao , O’Brien David R. , Yang Wei , Nehorai Arye , Adair-Kirk Tracy L. , Kopan Raphael , Dougherty J.D. 
Published: July 2015

AbstractDeeper understanding of the anatomical intermediaries for disease and other complex genetic traits is essential to understanding mechanisms and developing new interventions. Existing ontology tools provide functional annotations for many genes in the genome and they are widely used to develop mechanistic hypotheses based on genetic and transcriptomic data. Yet, information about where a set of genes is expressed may be equally useful in interpreting results and forming novel mechanistic hypotheses for a trait. Therefore, we developed a framework for statistically testing the relationship between gene expression across the body and sets of candidate genes from across the genome. We validated this tool and tested its utility on three applications. First, using thousands of loci identified by GWA studies, our framework identifies the number of disease-associated genes that have enriched expression in the disease-affected tissue. Second, we experimentally confirmed an underappreciated prediction highlighted by our tool: variation in skin expressed genes are a major quantitative genetic modulator of white blood cell count - a trait considered to be a feature of the immune system. Finally, using gene lists derived from sequencing data, we show that human genes under constrained selective pressure are disproportionately expressed in nervous system tissues.
Concerted activities of Mcm4, Sld3 and Dbf4 in control of origin activation and DNA replication fork progression
Authors: Sheu Yi-Jun , Kinney Justin B. , Stillman Bruce 
Published: July 2015

ABSTRACTEukaryotic chromosomes initiate DNA synthesis from multiple replication origins in a temporally specific manner during S phase. The replicative helicase Mcm2-7 functions in both initiation and fork progression and thus is an important target of regulation. Mcm4, a helicase subunit, possesses an unstructured regulatory domain that mediates control from multiple kinase signaling pathways, including the Dbf4-dependent Cdc7 kinase (DDK). Following replication stress in S phase, Dbf4 and Sld3, an initiation factor and essential target of Cyclin-Dependent Kinase (CDK), are targets of the checkpoint kinase Rad53 for inhibition of initiation from origins that have yet to be activated, so-called late origins. Here, whole genome DNA replication profile analysis is employed to access under various conditions the effect of mutations that alter the Mcm4 helicase regulatory domain and the Rad53 targets, Sld3 and Dbf4. Late origin firing occurs under genotoxic stress when the controls on Mcm4, Sld3 and Dbf4 are simultaneously eliminated. The regulatory domain of Mcm4 plays an important role in the timing of late origin firing, both in an unperturbed S phase and dNTP limitation. Furthermore, checkpoint control of Sld3 impacts fork progression under replication stress. This effect is parallel to the role of the Mcm4 regulatory domain in monitoring fork progression. Hypomorph mutations insld3are suppressed by amcm4regulatory domain mutation. Thus, in response cellular conditions, the functions executed by Sld3, Dbf4 and the regulatory domain of Mcm4 intersect to control origin firing and replication fork progression, thereby ensuring genome stability.
Producing the Ethylene Signal: Regulation and Diversification of Ethylene Biosynthetic Enzymes
Authors: Booker Matthew A. , DeLong Alison 
Published: July 2015

Abstract
Strictly controlled production of ethylene gas lies upstream of the signaling activities of this crucial regulator throughout the plant life cycle. Although the biosynthetic pathway is enzymatically simple, the regulatory circuits that modulate signal production are fine tuned to allow integration of responses to environmental and intrinsic cues. Recently identified posttranslational mechanisms that control ethylene production converge on one family of biosynthetic enzymes and overlay several independent reversible phosphorylation events and distinct mediators of ubiquitin-dependent protein degradation. Although the core pathway is conserved throughout seed plants, these posttranslational regulatory mechanisms may represent evolutionarily recent innovations. The evolutionary origins of the pathway and its regulators are not yet clear; outside the seed plants, numerous biochemical and phylogenetic questions remain to be addressed.
The Soybean-Specific Maturity Gene E1 Family of Floral Repressors Controls Night-Break Responses through Down-Regulation of FLOWERING LOCUS T Orthologs
Authors: Xu Meilan , Yamagishi Noriko , Zhao Chen , Takeshima Ryoma , Kasai Megumi , Watanabe Satoshi , Kanazawa Akira , Yoshikawa Nobuyuki , Liu Baohui , Yamada Tetsuya , Abe Jun 
Published: July 2015

Abstract
Photoperiodism is a rhythmic change of sensitivity to light, which helps plants to adjust flowering time according to seasonal changes in daylength and to adapt to growing conditions at various latitudes. To reveal the molecular basis of photoperiodism in soybean (Glycine max), a facultative short-day plant, we analyzed the transcriptional profiles of the maturity gene E1 family and two FLOWERING LOCUS T (FT) orthologs (FT2a and FT5a). E1, a repressor for FT2a and FT5a, and its two homologs, E1-like-a (E1La) and E1Lb, exhibited two peaks of expression in long days. Using two different approaches (experiments with transition between light and dark phases and night-break experiments), we revealed that the E1 family genes were expressed only during light periods and that their induction after dawn in long days required a period of light before dusk the previous day. In the cultivar Toyomusume, which lacks the E1 gene, virus-induced silencing of E1La and E1Lb up-regulated the expression of FT2a and FT5a and led to early flowering. Therefore, E1, E1La, and E1Lb function similarly in flowering. Regulation of E1 and E1L expression by light was under the control of E3 and E4, which encode phytochrome A proteins. Our data suggest that phytochrome A-mediated transcriptional induction of E1 and its homologs by light plays a critical role in photoperiodic induction of flowering in soybean.
User studies and user education programmes in archival institutions
Authors: Katuu Shadrack 
Published: July 2015

Purpose
– The purpose of this paper is to examine user studies as well as user education within the context of public services offered by archival institutions. It highlighted some of the key aspects that constitute both concepts drawing from history in order to provide a better understanding in the context of current professional discussions.

Design/methodology/approach
– The review analysed peer-reviewed articles ranging from the late 1970s to the present time to illuminate debates in the archival professional underpinning the current understanding of user studies and user education.

Findings
– The paper outlined the different paths used in user studies to ensure data collection is exhaustive and provides a nuanced assessment of user needs. It also outlined the two related paradigms of structuring user education programmes, highlighted the points at which they differ and the rich discussions resulting from comparative analysis.

Originality/value
– The paper demonstrated that there is a rich corpus of professional literature on both user studies and user education, expounding on different aspects that would ensure both are designed and implemented effectively.
Knowledge management reliability assessment: an empirical investigation
Authors: Hesamamiri Roozbeh , Mahdavi Mazdeh Mohammad , Jafari Mostafa , Shahanaghi Kamran 
Published: July 2015

Purpose
– A perfect knowledge management (KM) initiative is one that achieves its objectives without any failure during a pre-defined period. However, KM implementation is not perfect in every organization as it requires substantial changes in organizational infrastructures, including culture, structure, and technology. Therefore, the purpose of this paper is to propose a model for assessing the reliability of KM to help organizations evaluate their ability to implement KM successfully by identifying key reliability variables, modeling the complex interaction structure among variables, and determining the probability of failure for each KM capability.

Design/methodology/approach
– In this study, relevant variables are identified by a thorough analysis of related references in literature. In order to determine the compound structure of complicated interactions among variables, a group-based approach is utilized. Based on the combined cognitive maps, a cognitive network is constructed as a framework for graphically representing the logical relationships between variables and capturing the uncertainty in the dependency among these variables using conditional probabilities. The applicability of the proposed approach and the efficacy of the model was verified and validated with data from a banking institution.

Findings
– Results show that KM reliability can be defined by the degree to which required KM capabilities, including infrastructure and process capabilities, have the ability to perform as intended in a certain organizational environment. Furthermore, it is demonstrated that reliability assessment of KM through a hybrid approach of fuzzy cognitive map and Bayesian network is possible and useful.

Practical implications
– The proposed reliability assessment model facilitates the process of understanding why and how failures occur in KM. Moreover, the proposed approach evaluates the probability of success for each variable as well as for the entire KM initiative. Therefore, it can provide insight for managers and executives into the degree of reliability for their existing KM and prevention of failures in vital factors through necessary actions.

Originality/value
– The suggested approach to KM reliability assessment is a novel method that provides powerful arguments for a more holistic view of KM reliability factors, which is crucial for the successful implementation of KM.
Book or NOOK? Information behavior of academic librarians
Authors: McDonald Elizabeth , Rosenfield Marina , Furlow Tim , Kron Tara , Lopatovska Irene 
Published: July 2015

Purpose– The purpose of this paper is to understand patterns in information behavior of academic librarians, individuals who influence information technology adoption in academic libraries and parent institutions. Librarians’ perception of their student patrons’ information behavior was also investigated.Design/methodology/approach– An exploratory study investigated professional and personal information behavior of eight librarians employed by various academic institutions in the Greater New York City area. The data were collected in face-to-face interviews and analyzed using the content analysis technique.Findings– The study found that librarians’ institutional affiliations had no effect on their information behavior. The patterns in librarians’ information behavior at work and leisure suggest that those behaviors are influenced by contextual variables, personal preferences and tasks, and are no different from the general population. Overall, librarians had accurate, evidence-driven understanding of their student patrons’ information behavior.Research limitations/implications– The study findings have limited generalizability due to the small sample size and limited geographical pool of participants.Practical implications– Academic library is often seen as the hub of the adoption of information technologies as librarians introduce new digital content and resources to the rest of academia. Understanding information behavior of academic librarians contributes to understanding factors that are affecting technology adoption in academia overall, and can potentially inform recommendations for optimizing academic library offerings.Originality/value– The study is an original investigation of the relationships between institutional characteristics and librarian demographics, librarian information behavior at work and leisure, and librarians’ perception of students’ information behavior and information preferences.
Dynamic phasor analysis and design of phase-locked loops for single phase grid connected converters
Authors: Rashed Mohamed , Klumpner Christian , Asher Greg 
Published: July 2015

Purpose
– The purpose of the paper is to introduce the dynamic phasor modelling (DPM) approach for stability investigation and control design of single-phase phase-locked loops (PLLs). The aim is to identify the system instabilities not predicted using the existent analysis and design methods based on the simplified average model approach.

Design/methodology/approach
– This paper starts by investigating the performance of three commonly used PLL schemes: the inverse park-PLL, the second-order generalised integrators (SOGI)-frequency-locked loop and the enhanced-PLL, designed using the simplified average model and will show that following this approach, there is a mismatch between their actual and desired transient performance. A new PLL design method is then proposed based on the DPM approach that allows the development of fourth-order DPM models. The small-signal eigenvalues analysis of the fourth-order DPM models is used to determine the control gains and the stability limits.

Findings
– The DPM approach is proven to be useful for single-phase PLLs stability analysis and control parameters design. It has been successfully used to design the control parameters and to predict the PLL stability limits, which have been validated via simulation and experimental tests consisting of grid voltage sag, phase jump and frequency step change.

Originality/value
– This paper has introduced the use of DPM approach for the purpose of single-phase PLL stability analysis and control design. The approach has enabled accurate control gains design and stability limits identification of single-phase PLLs.
Efficiency optimization of a two-port microwave oven: a robust automated procedure
Authors: Bressan Fernando , Dughiero Fabrizio , Bullo Marco , Di Barba Paolo 
Published: July 2015

Purpose
– In the paper, a single-objective optimization problem characterized by high-frequency field analysis is investigated: the optimal design of a two-port microwave (MW) oven, taking into account the possibility of two independently controlled sources, with the aim of improving the efficiency is considered as the case study. The paper aims to discuss these issues.

Design/methodology/approach
– A high-frequency field analysis has been coupled to a robust evolutionary-computing algorithm in order to create an appropriate procedure for the optimal design of a MW oven based on a cascade optimization: in the first step the optimized geometry has been identified, while in the second step the optimized electrical supply values have been synthesized. In particular, the direct problem has been faced by means of a 3D-FEM approach in order to obtain realistic results; the inverse problem has been faced by means of a derivative-free robust algorithm based on evolutionary strategy in order to get a fast convergence of the solution.

Findings
– A new design procedure for high efficiency MW ovens for household application by means of the proposed numerical approach.

Practical implications
– These results allow industrial designers to improve this kind of devices.

Originality/value
– The original contribution of the paper is the systematic approach to the optimal design of a MW oven with multiple feeding, based on the link between an algorithm of evolutionary strategy optimization algorithm and a finite-element solver.