bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parents' experiences on handling paediatric anticancer drugs at home after an educational intervention
Authors: Akkawi El Edelbi Ranaa , Eksborg Staffan , Kreicbergs Ulrika , Lövgren Malin , Ekman Jennie , Lindemalm Synnöve 
Published: July 2024

AbstractBackgroundThe shift of treatment of paediatric cancer patients to include more care at home puts a lot of pressure on health care professionals (HCPs) to prepare and train parents on safe and correct drug handling at home. Parents must take in and understand the information presented to them while coping with their own fear related to their child's cancer diagnosis. In Sweden, parents are expected to handle and manipulate oral anticancer drugs (OADs) in the home setting. There is however a lack of a standardized method to inform and educate parents on how to handle OADs in a correct way at home.AimTo describe parents' experiences of handling OADs at home after participating in an educational intervention.MethodEducational intervention in the present study aimed to improve parents' knowledge in key concepts that is, handling OADs at home by using information presented in different forms. Fifteen parents to 12 children with cancer were recruited from a paediatric oncology ward in Sweden to participate in an interview. The interviews were transcribed verbatim and subjected to qualitative content analysis.ResultsParents' experiences are presented in categories: Relieved stress, Awareness of own exposure, Facilitated my everyday life, Parents need continued support individually. The educational intervention resulted in both positive and negative feelings, increased awareness of drug exposure and correct drug handling at home. Practical training and information presented in different ways facilitated the process of drug handling. To handle the drug correctly at home parents requested to be trained and informed in the beginning of their child's oral drug treatment. In addition, parents requested to be individually approached by HCP to get answers to questions and concerns.ConclusionsThis educational intervention study shows promising results for the method used by HCPs to inform and educate parents on complicated topics such as handling OADs at home.
Are Peruvians moving toward healthier diets with lower environmental burden? Household consumption trends for the period 2008–2021
Authors: Sanchez‐Matos Joan , Vázquez‐Rowe Ian , Kahhat Ramzy 
Published: July 2024

AbstractPeru is one of the most diverse countries in the world in terms of food production, but also suffers a wide range of food security challenges, including malnutrition, the impact of natural hazards, and rising food prices. People living in poverty conditions are the main victims of these problems, which trigger undernutrition, obesity, and diet‐related non‐transmittable diseases. Despite these challenges, Peru lacks historical food intake data. Therefore, in the current study, we assess the diet quality evolution in the period 2008–2021 based on apparent household purchases extracted from the National Household Survey. The results reveal significant variations in the consumption of certain food items and groups, and the consequences of these changes are discussed in environmental and human health terms. The consumption of lower environmental impact animal protein, such as chicken, eggs, and marine fish, has increased by 37%, 69%, and 29%, respectively; whereas the consumption of high environmental impact foods, such as beef and other red meat, has decreased. Moreover, consumption of less processed carbohydrate sources (e.g., legumes, fruits, and vegetables) has risen, while refined sugar and sugar‐sweetened beverages have decreased significantly (almost 45%). Regional differences were also visible; hence, cities on the Northern coast and the Amazon basin had similar consumption habits, whereas Central/Southern coastal and Andean cities had closer consumption patterns. On average, this improvement was reflected in the increase in calories (9.9%) and macronutrient intake (up to 15%), but at the socioeconomic level, food inequality persists, with consumption of many food groups below minimum thresholds in lower socioeconomic strata. This article met the requirements for a gold/gold JIE data openness badge described at http://jie.click/badges.
Isochemical metamorphism origin of the newly discovered Baqing jadeitoid, eastern‐central Tibet, China
Authors: Jin Xin , Whitney Donna L. , Zhang Yu‐Xiu , Blatchford Hannah J. , Zhang Kai‐Jun , Tsujimori Tatsuki , Xiao Yuan‐Yuan , Liu Hai‐Yang , von der Handt Anette , Yan Li‐Long , Liu Yao , Lu Lu , Li Cong‐Ying 
Published: July 2024

AbstractThe formation of most jadeitites and other jadeite‐rich rocks (jadeitoids) during subduction is thought to occur by precipitation (P‐type) or metasomatism (R‐type) by infiltration of Na‐Al‐Si‐rich aqueous fluids because of the compositional similarity of the rocks to inferred subduction fluids. Whether these rocks can form by isochemical metamorphism (I‐type) during subduction is still hotly debated. A characteristic of I‐type jadeitoid is that it exhibits a similar prograde metamorphic record as associated eclogite, in contrast to P‐ and R‐type jadeitite and jadeitoids that are typically enclosed in serpentinite derived from the mantle wedge and either lack a prograde metamorphic history (R‐type and P‐type) or probably experience a prograde history (R‐type) that is difficult to discern owing to the high variance of the jadeite‐dominated assemblages and alteration by subduction fluids. The recently discovered Baqing (eastern‐central Tibet) jadeitoid is enclosed by quartzo‐feldspathic schist and has a peak metamorphic assemblage of almandine + jadeite/omphacite + phengite/paragonite + rutile + quartz, similar to eclogite. Abundant mineral inclusions in almandine, especially rutile inclusions with increasing Zr contents from the core to rim of almandine, provide an opportunity to further decode the jadeitoid‐forming processes. In this study, pseudosections and Zr‐in‐rutile thermometry, together with conventional geothermobarometers, were employed to decipher the metamorphic history of Baqing jadeitoids. Two analysed Baqing jadeitoids exhibit a similar clockwise P–T path, starting from early metamorphic conditions of 5–7 kbar, 350–440°C, to different peak conditions (27–29 kbar, 730–760°C, or 20–23 kbar, 670–710°C), followed by relatively consistent retrograde metamorphic conditions of 6–7 kbar, 530–600°C. This result indicates a similar subduction history to the Baqing eclogite. In addition, the Baqing jadeitoids show similar geochemical characteristics to some Na‐rich, K‐depleted and Ca‐depleted sedimentary rocks or plagiogranite. Therefore, we propose an isochemical genesis for the Baqing jadeitoid, rather than a metasomatic origin.
Neuromuscular electrical stimulation for facial wrinkles and sagging: The 8‐week prospective, split‐face, controlled trial in Asians
Authors: Omatsu Jun , Yamashita Takashi , Mori Toko , Osuji Yurika , Kawanabe Ruriko , Kuzumi Ai , Yoshizaki Asako , Yokota Tomomi , Yamazaki Kentaro , Sato Shinichi , Yoshizaki Ayumi 
Published: July 2024

AbstractObjectiveThis study aims to fill the knowledge gap regarding the effects of high frequency facial neuromuscular electrical stimulation (fNMES) on facial aging, using a device equipped with CERTEC (Cell Energy Regeneration Technology) operating between 40 and 190 kHz.MethodsThis prospective split‐face study was conducted at Tokyo University Hospital between March and May 2023 with 24 healthy adult women aged 30–59. The intervention group used the fNMES device along with basic skin care on one side of the face, and basic skin care alone on the other side for 8 weeks. Evaluations included changes in skin wrinkles, sagging, and blood flow.ResultsThis study found significant improvements in skin elasticity and degree of wrinkles in the areas intervened with fNMES (p < 0.05, respectively). In addition, the intervention resulted in significant improvements in jawline angle (p < 0.01), submental volume (p < 0.05), cheek volume (p < 0.05), maximum nasolabial fold depth (p = 0.03), and total volume of the nasolabial folds (p = 0.03). The fNMES intervention also showed improvement in blood flow (p < 0.05). These improvements were also subjectively assessed by the participants in subject questionnaires at 8 weeks after the intervention (p < 0.05).ConclusionThis study suggests that high frequency fNMES effectively improves facial skin elasticity, reduces wrinkles and sagging, promotes blood flow, and contributes to overall facial appearance rejuvenation. Although further studies are needed, high frequency fNMES appeared promising as a noninvasive anti‐aging therapy.
Influence of multi‐stressor combinations of pCO2, temperature, and salinity on the toxicity of Heterosigma akashiwo (Raphidophyceae), a fish‐killing flagellate
Authors: Allaf Malihe Mehdizadeh , Trick Charles G. 
Published: July 2024

AbstractClimate change and global warming have led to more frequent harmful algal blooms in the last decade. Among these blooms, Heterosigma akashiwo, a golden‐brown phytoflagellate, is one of the 40 species with a high potential to form harmful blooms, leading to significant fish mortality. Climate change leads to rising atmospheric and ocean temperatures. These changes, along with altered rainfall patterns and meltwater input, can cause fluctuations in ocean salinity. Elevated atmospheric carbon dioxide (CO2) levels increase water acidity as oceans absorb CO2. This study investigated the effects of temperature, salinity, and CO2 levels on lipid production, hemolytic activity, and toxicity of H. akashiwo using the design of experiment approach, which can be used to investigate the effect of two or more factors on the same response simultaneously in a precise manner with fewer experiments and materials but in a larger region of the factor space. The lipid content was measured using a high‐throughput Nile Red method, and the highest level of lipid content was detected at 25°C, a salinity of 30, and a CO2 concentration of 400 ppm. Hemolytic activity was assessed using rabbit blood erythrocytes in a 96‐well plate, and the optimal conditions for achieving the highest hemolytic activity were determined at 15°C, a salinity of 10, and a CO2 concentration of 400 ppm. As the chemical structure of the toxin is not known, we used the toxicity against the cell line RTgill‐W1 as the cell toxicity proxy. The maximum toxicity was identified at 15°C, a salinity of 10, and a CO2 level of 700 ppm.
Gut microbial dysbiosis and inflammation: Impact on periodontal health
Authors: Zhao Yifan , Liu Yi , Jia Lu 
Published: July 2024

AbstractPeriodontitis is widely acknowledged as the most prevalent type of oral inflammation, arising from the dynamic interplay between oral pathogens and the host's immune responses. It is also recognized as a contributing factor to various systemic diseases. Dysbiosis of the oral microbiota can significantly alter the composition and diversity of the gut microbiota. Researchers have delved into the links between periodontitis and systemic diseases through the “oral–gut” axis. However, whether the associations between periodontitis and the gut microbiota are simply correlative or driven by causative mechanistic interactions remains uncertain. This review investigates how dysbiosis of the gut microbiota impacts periodontitis, drawing on existing preclinical and clinical data. This study highlights potential mechanisms of this interaction, including alterations in subgingival microbiota, oral mucosal barrier function, neutrophil activity, and abnormal T‐cell recycling, and offers new perspectives for managing periodontitis, especially in cases linked to systemic diseases.
Centralized management of copyright royalties: A case study on the National Collective Management Organization for songs and music in Indonesia
Authors: Ayu Palar Miranda Risang , Rafianti Laina , Puspitasari Wina , Novianti Isti 
Published: July 2024

AbstractThis paper tries to examine the role and function of the National Collective Management Organization (NCMO) and Collective Management Organizations (CMOs) for songs and music authors along with their related rights based on the existing law and implementing regulations in Indonesia. The discussion specifically revolves around controversies, challenges, advantages, and disadvantages that occurred from the centralized management system in songs and music conducted by NCMO to ease the royalties payment process for commercial users. The research was made by analyzing qualitative data on the laws and their implementing regulations in Indonesia, and also formal reports, it is supported by in‐depth observation and interviews with selected sources in the fields. Results show that to perform its task as the centralized management body for royalties of copyrights in Indonesia, the NCMO has to transform the way they operate. There are three practicable and acceptable options of transformation which all shall require a structural change, transparency, and reasonable operational costs shared in terms of NCMO's and CMOs' operation. It must also involve improvement in consistency to NCMO, CMOs, and other related agencies to act as trustee bodies.
Ontogenetic variation in the marine foraging of Atlantic salmon functionally links genomic diversity with a major life history polymorphism
Authors: Aykanat Tutku , Jacobsen Jan Arge , Hindar Kjetil 
Published: July 2024

AbstractThe ecological role of heritable phenotypic variation in free‐living populations remains largely unknown. Knowledge of the genetic basis of functional ecological processes can link genomic and phenotypic diversity, providing insight into polymorphism evolution and how populations respond to environmental changes. By quantifying the marine diet of Atlantic salmon, we assessed how foraging behaviour changes along the ontogeny, and in relation to genetic variation in two loci with major effects on age at maturity (six6 and vgll3). We used a two‐component, zero‐inflated negative binomial model to simultaneously quantify foraging frequency and foraging outcome, separately for fish and crustaceans diets. We found that older salmon forage for both prey types more actively (as evidenced by increased foraging frequency), but with a decreased efficiency (as evidenced by fewer prey in the diet), suggesting an age‐dependent shift in foraging dynamics. The vgll3 locus was linked to age‐dependent changes in foraging behaviour: Younger salmon with vgll3LL (the genotype associated with late maturation) tended to forage crustaceans more often than those with vgll3EE (the genotype associated with early maturation), whereas the pattern was reversed in older salmon. Vgll3 LL genotype was also linked to a marginal increase in fish acquisition, especially in younger salmon, while six6 was not a factor explaining the diet variation. Our results suggest a functional role for marine feeding behaviour linking genomic diversity at vgll3 with age at maturity among salmon, with potential age‐dependent trade‐offs maintaining the genetic variation. A shared genetic basis between dietary ecology and age at maturity likely subjects Atlantic salmon populations to evolution induced by bottom‐up changes in marine productivity.
The violence of curriculum: Dismantling systemic racism, colonisation and indigenous erasure within medical education
Authors: Razack Saleem , Richardson Lisa , Pillay Suntosh R. 
Published: July 2024

AbstractBackgroundEpistemic violence is enacted in medical curricula in mundane ways all the time, negatively impacting learners, teachers and patients. In this article, we address three forms of such violence: White supremacy, indigenous erasure and heteronormativity.MethodsIn this article, we examine the knowledge systems of medicine as a global phenomenon, impacted by Western and European ideologies of race and colonisation, both produced by them, helping to reproduce them through authoritative and hegemonic ideologies. We seek not only to problematise but also to propose alternative teaching approaches rooted in the Global South and in Indigenous ways of knowing. Taking inspiration from Paulo Freire, we advocate for the development of critical consciousness through the integration of critical pedagogies of love, emancipation and shared humanity. Drawing on Irihapeti Ramsden, we advocate for cultural safety, which emphasises power relations and historical trauma in the clinical encounter and calls for a rights‐based approach in medical education. Deliberately holding space for our own vulnerabilities and that of our students requires what Megan Boler calls a pedagogy of discomfort.Conclusions and SignificanceOur perspectives converge on the importance of critical consciousness development for culturally safe practice in medical education, acknowledging the need to emphasise a curriculum of shared humanity, introducing the concept of Ubuntu from Southern Africa. Ubuntu can be encapsulated in the phrase ‘I am because we are’, and it promotes a collective approach to medical education in which there is active solidarity between the profession and the diverse populations which it serves.
Aristotle's tyche (τύχη) and contemporary debates about luck
Authors: Groarke Louis 
Published: July 2024

AbstractThis paper proposes an interpretation of Aristotle's understanding of tyche (τύχη), a Greek term that can be alternatively translated as luck, fortune, or fate. The paper disentangles various threads of argument in the primary sources to argue for a realist understanding of what we moderns call “luck.” In short, it contends that Aristotle's account of these issues is mostly correct and merits close attention when canvassing recent philosophical debates about luckology. Aristotle argues that science pertains to the general rule; it is not about the particular. Particular events have contingent content that exceeds the scope of science. Even if we could predict all future events with ultimate accuracy, we would still be left wondering why good or bad things happen to specific people. Although luck is not a scientific category, it has an existential reality that leaves momentous events open to metaphysical and even religious interpretation.
A dimensional analysis of experienced intensive care unit nurses' clinical decision‐making for bleeding after cardiac surgery
Authors: Lavoie Patrick , Arbour Caroline , Garneau Amélie Blanchet , Côté José , Crétaz Maude , Denault André , Gosselin Émilie , Lapierre Alexandra , Mailhot Tanya , Tessier Virginie 
Published: July 2024

AbstractBackgroundBleeding following cardiac surgery is common and serious, yet a gap persists in understanding how experienced intensive care nurses identify and respond to such complications.AimTo describe the clinical decision‐making of experienced intensive care unit nurses in addressing bleeding after cardiac surgery.Study DesignThis qualitative study adopted the Recognition‐Primed Decision Model as its theoretical framework. Thirty‐nine experienced nurses from four adult intensive care units participated in semi‐structured interviews based on the critical decision method. The interviews explored their clinical judgements and decisions in bleeding situations, and data were analysed through dimensional analysis, an alternative to grounded theory.ResultsParticipants maintained consistent vigilance towards post‐cardiac surgery bleeding, recognizing it through a haemorrhagic dimension associated with blood loss and chest drainage and a hypovolemic dimension focusing on the repercussions of reduced blood volume. These dimensions organized their understanding of bleeding types (i.e., normal, medical, surgical, tamponade) and necessary actions. Their decision‐making encompassed monitoring bleeding, identifying the cause, stopping the bleeding, stabilizing haemodynamic and supporting the patient and family. Participants also adapted their actions to specific circumstances, including local practices, professional autonomy, interprofessional dynamics and resource availability.ConclusionsNurses' decision‐making was shaped by their personal attributes, the patient's condition and contextual circumstances, underscoring their expertise and pivotal role in anticipating actions and adapting to diverse conditions. The concept of actionability emerged as the central dimension explaining their decision‐making, defined as the capability to implement actions towards specific goals within the possibilities and constraints of a situation.Relevance to Clinical PracticeThis study underscores the need for continual updates to care protocols to align with current evidence and for quality improvement initiatives to close existing practice gaps. Exploring the concept of actionability further, developing adaptability‐focused educational programmes, and understanding decision‐making intricacies are crucial for informing nursing education and decision‐support systems.
He Uiui Aromatawai Tūraru: Guidance for ‘risky’ and uncertain resource use decision‐making in Aotearoa
Authors: Le Heron Erena , Le Heron Richard , Awatere Shaun , Blackett Paula , Logie June , Hyslop Jade 
Published: July 2024

AbstractRecent environmental events in land, coastal and ocean domains in Aotearoa have raised serious questions about risks and uncertainties connected with natural resource decision‐making at all levels and in all places. Evidence from consenting processes associated with proposed investments in seabed mining of Chatham Rock Phosphate and sub‐division development at Okura, Auckland City, illustrate the presence and nature of three key but often invisible influences – personal positionalities, discipline assumptions and worldviews – affecting decision processes. Readers are invited to go on a ‘risk journey’, of discovery, to help develop their capabilities to engage in investment decision‐making processes.
CASTing the net wider: A case report of PLACK syndrome associated with dilated cardiomyopathy
Authors: Nguyen Cassidy , Hughes Connor , Little Samantha , Carruth Alexander , Nolan Daniel , Ruth Jennifer 
Published: July 2024

AbstractPLACK syndrome (OMIM 616295) is a rare genodermatosis associated with peeling skin, leukonychia, acral punctate keratosis, cheilitis, and knuckle pads and is caused by loss‐of‐function mutations in the CAST gene, which encodes calpastatin, a calcium‐dependent protease. This case report highlights a case of PLACK syndrome presenting with the unique findings of striate hyperkeratosis on the palms as well as life‐threatening cardiomyopathy. We review why CAST mutations might impact cardiac function and raise awareness of the potential association between PLACK syndrome and cardiac manifestations.