bluuebunny/crossref_metadata_2025_split huggingface dataset:
Litsea cubeba essential oil: Extraction, chemical composition, antioxidant and antimicrobial properties, and applications in the food industry
Authors: Liu Yao , Ren Huanhuan , Li Kehu 
Published: July 2024

AbstractLitsea cubeba (Lour.) Pers. (Lauraceae) is a valuable industrial crop that produces essential oil. The essential oil extracted from L. cubeba (LCEO) has broad‐spectrum antimicrobial activity and high antioxidant properties, with great potential for increased usage in the food industry. This literature review summarizes the extraction techniques, content and chemical composition, and antioxidant and antimicrobial activities of LCEO, with a focus on its usage in the food industry, which is an area of substantial recent research. The chemical composition of LCEO, which is affected by various factors, plays a key role in determining its bioactivity and usage in food. The potent antimicrobial activity of LCEO against various foodborne pathogens gives it potential for use in food packaging and preservation to extend shelf life. Future research challenges include the elucidation of the role and mechanism of individual chemical components of LCEO in inhibiting specific foodborne microorganisms; cultivar development to produce germplasm that yields essential oils of the desired chemical composition; and the development of commercial products that can be used in the food industry.
The effect of free and encapsulated probiotic bacteria on some physicochemical, microbiological, and textural properties of apricot leather (pestil) during storage
Authors: Bagdat Elif Seyma , Kutlu Gozde , Tornuk Fatih 
Published: July 2024

AbstractPestil, also known as fruit leather, has emerged as a promising non‐dairy carrier for probiotics, utilizing apricots and incorporating probiotics into its formulation. This study aimed to develop a healthy snack bar by incorporating three distinct strains of probiotic bacteria, both in free and encapsulated forms, into the recipe of apricot leather. The physicochemical, bioactive, microbiological, and textural attributes of the resulting apricot pestils were evaluated over a 120‐day storage period. Fluctuations in pH (4.74–4.97) were observed during storage, whereas water activity (0.31–0.45) and moisture content (8.05%–13.40%) exhibited a decreasing trend over time. Incorporating free or encapsulated bacteria resulted in a darker surface, attributed to the intermolecular interactions between probiotics and the pestil matrix. The initial total phenolic content was highest and declined significantly during storage (52.13–291.73 mg gallic acid equivalent/100 g) (p < 0.05). Viability was found to be higher in the encapsulated forms of bacteria at the conclusion of the storage period. Overall, apricot pestil emerged as a promising matrix for viable probiotics, facilitating their delivery and hosting in both free and encapsulated forms during storage.
Effect of testosterone formulations on hematocrit in transgender individuals: A systematic review
Authors: Okano Sérgio Henrique Pires , Braga Giordana Campos , Cantelli Débora Aiesha Leite , Filho Luis Antônio S. Pires , Brito Luiz Gustavo Oliveira , Lara Lucia Alves da Silva 
Published: July 2024

AbstractBackgroundApproximately, 11% of trans men experience erythrocytosis diagnosis due to testosterone administration during the first year of the gender‐affirming hormone treatment (GAHT).ObjectivesTo identify and compare the effect of different testosterone formulations on hematocrit (Hct) and diagnose erythrocytosis in trans men.Materials and methodsThis systematic review was based on PRISMA guidelines. We performed an electronic search of PubMed, Embase, and Web of Science in January 2024. The Newcastle–Ottawa scale was used to evaluate the quality of evidence in the observational studies.ResultsOf the 152 records retrieved, 18 met the eligibility criteria. Studies observed an increase of up to 5% in Hct in trans men using injectable testosterone undecanoate (TU), and up to 6.9% in trans men using intermediate injectable testosterone esters (TE). Trans men using TE experience a larger increase in serum Hct levels compared to those receiving TU. Erythrocytosis prevalence varies according to the cutoff used (50%, 52%, and 54%). Erythrocytosis was also associated with tobacco use, age at initiation of hormone therapy, body mass index (BMI), and pulmonary conditions. Studies that evaluated the effect of testosterone formulation on erythrocytosis diagnosis present conflicting result. Trans men have a hazard ratio of 7.4 (95% CI: 4.1, 13.4) of developing erythrocytosis compared to cisgender men, using a 52% hematocrit cutoff.ConclusionAll testosterone formulations result in an increase in Hct, irrespective of dose, formulation, and administration method. Smoking, higher age at initiation of the testosterone therapy, higher BMI, and a predisposing medical history are associated with this increase in Hct. The difference in effect of TE and TU on Hct is conflicting, although it is important to point out that these data come from observational studies, retrospective, and with a small‐sample size.
The “Temporal Rift” and the Temporalities of the Capitalist Social Metabolism
Authors: Rey‐Araújo Pedro M. 
Published: July 2024

AbstractThis paper advances a reading of the social metabolism as a dynamic orchestration of heterogeneous rhythms, encompassing those intrinsic to human bodies and other natural processes, and those of relations mediating both. Contrary to pre‐capitalist societies, as the collective mediation of the social metabolism adopts a capitalist form, it becomes autonomised from its conditions of existence, and a “temporal rift” emerges, with two distinct dimensions: the rhythmic conditions of regeneration of human bodies and natural processes, as well as the terms of occurrence of non‐subsumed practices, become subordinated to capital's reproductive needs, thus compromising the reproduction of all Earthly life.
Letter: Reflections on the role of over‐the‐scope clips in high‐risk upper gastrointestinal bleeding
Authors: Wang Yajie , Pan Yisheng 
Published: July 2024

LINKED CONTENTThis article is linked to He et al papers. To view these articles, visit https://doi.org/10.1111/apt.18093 and https://doi.org/10.1111/apt.18173
Outcomes of patients with alcohol‐associated hepatitis and acute kidney injury – Results from the HRS Harmony Consortium
Authors: Ma Ann T. , Allegretti Andrew S. , Cullaro Giuseppe , Ouyang Tianqui , Asrani Sumeet K. , Chung Raymond T. , Przybyszewski Eric M. , Wilechansky Robert M. , Robinson Jevon E. , Sharma Pratima , Simonetto Douglas A. , Jalal Prasun , Orman Eric S. , Wadei Hani M. , St. Hillien Shelsea A. , Saly Danielle , Ufere Nneka N. , Dageforde Leigh Anne , Regner Kevin R. , Belcher Justin M. , Patidar Kavish R. ,   from the HRS Harmony Consortium
Published: July 2024

SummaryBackground & AimsThe development of acute kidney injury (AKI) in the setting of alcohol‐associated hepatitis (AH) portends a poor prognosis. Whether the presence of AH itself drives worse outcomes in patients with cirrhosis and AKI is unknown.MethodsRetrospective cohort study of 11 hospital networks of consecutive adult patients admitted in 2019 with cirrhosis and AKI. AKI phenotypes, clinical course, and outcomes were compared between AH and non‐AH groups.ResultsA total of 2062 patients were included, of which 303 (15%) had AH, as defined by National Institute on Alcohol Abuse and Alcoholism (NIAAA) criteria. Patients with AH, compared to those without, were younger and had higher Model for End‐stage Liver Disease‐Sodium (MELD‐Na) scores on admission. AKI phenotypes significantly differed between groups (p < 0.001) with acute tubular necrosis occurring more frequently in patients with AH. Patients with AH reached more severe peak AKI stage, required more renal replacement therapy, and had higher 90‐day cumulative incidence of death (45% [95% CI: 39%–51%] vs. 38% [95% CI: 35%–40%], p = 0.026). Using no AH as reference, the unadjusted sHR for 90‐day mortality was higher for AH (sHR: 1.24 [95% CI: 1.03–1.50], p = 0.024), but was not significant when adjusting for MELD‐Na, age and sex. However, in patients with hepatorenal syndrome, AH was an independent predictor of 90‐day mortality (sHR: 1.82 [95% CI: 1.16–2.86], p = 0.009).ConclusionsHospitalised patients with cirrhosis and AKI presenting with AH had higher 90‐day mortality than those without AH, but this may have been driven by higher MELD‐Na rather than AH itself. However, in patients with hepatorenal syndrome, AH was an independent predictor of mortality.
Successful treatment of feline pancreatolithiasis associated with an ascending Providencia rettgeri infection using a novel surgical technique
Authors: Loh JR , Cleland N , Korman R 
Published: July 2024

A 12‐year‐old female spayed Domestic Shorthair cat presented with a 4‐day history of lethargy, inappetence and vomiting. Physical findings included a grade 2/6 heart murmur and cranial abdominal pain on palpation. Serum biochemistry revealed elevated total bilirubin and liver enzymes activities. Abdominal ultrasound revealed multiple pancreatoliths, cholelithiasis and dilation of the pancreatic duct. During exploratory laparotomy, catheterisation of the pancreatic duct with retrograde and orthograde flushing to remove the pancreatoliths was performed via a distal enterotomy and proximal left apical partial pancreatectomy respectively. Catheterisation and flushing of the common bile duct were performed to confirm patency prior to cholecystectomy. Bacterial culture of pancreatoliths, pancreatic tissue and bile grew a heavy, pure growth of Providencia rettgeri. Fluorescent immunostaining histopathology revealed clusters of rod‐shaped bacteria within the pancreatic parenchyma and gall bladder mucosa. The cat received pradofloxacin for two weeks. She made a complete recovery and remained well at a six‐month follow‐up.
How and when employees' attributions of their employers' CSR activities affect their extra‐role work behavior
Authors: Castro‐Casal Carmen , Vila‐Vázquez Guadalupe , García‐Chas Romina 
Published: July 2024

AbstractThe objective of this research is to examine how and when employees' attributions of corporate social responsibility (CSR) affect their extra‐role service behaviors. The research analyses the mediating role of work meaningfulness in the employees' CSR attributions–extra‐role behaviors relationships. The moderating role of employees' attitudes toward CSR in both the relationships between CSR attributions and work meaningfulness and in the mediated relationship is also studied. The hypotheses were tested on a sample of 204 frontline employees of four‐ and five‐star hotels in Spain using structural equations and the PROCESS macro. The results indicate that only substantive CSR attributions positively influenced employees' extra‐role service behaviors and that the relationship occurs through the work meaningfulness experienced by employees. While substantive CSR attributions boosted work meaningfulness and subsequent extra‐role service behavior regardless of personal attitudes toward CSR, the link between symbolic CSR attributions and work meaningfulness as well as the mediated relationship with extra‐role service behaviors were found to be moderated by employees' personal attitudes toward CSR. When employees had lower personal attitudes toward CSR, symbolic CSR attributions positively affected work meaningfulness and extra‐role service behavior; when attitudes toward CSR were higher, the relationships were not significant. Interesting theoretical contributions and practical insights follow from these findings.
Access to best‐evidenced mental health support for care‐experienced young people: Learnings from the implementation of cognitive therapy for PTSD
Authors: McGuire Rosie , Meiser‐Stedman Richard , Smith Patrick , Schmidt Davin , Bjornstad Gretchen , Bosworth Robyn , Clarke Timothy , Coombes Joe , Geijer Simpson Emma , Hudson Kristian , Oliveira Paula , Macleod John , McGovern Ruth , Stallard Paul , Wood Katie , Hiller Rachel M. 
Published: July 2024

AbstractObjectivesRates of PTSD are up to 12 times higher in care‐experienced young people (CEYP) compared to their peers. Trauma‐focused CBTs (tf‐CBT) are the best‐evidenced treatment for youth with PTSD, yet, in practice, CEYP often struggle to access this treatment. We worked alongside services to understand barriers and facilitators of the implementation of cognitive therapy for PTSD (a type of tf‐CBT) to CEYP.DesignThis was an active, open implementation trial.MethodsWe recruited 28 mental health teams across England, including general CAMHS, targeted CAMHS for CEYP and social care‐based teams. From these teams, participants were 243 mental health professionals, from a wide variety of professional backgrounds. Following recruitment/intervention training, teams participated in rolling three monthly focus groups and individual interviews, to understand what helped and hindered implementation. Data were analysed using a framework analysis conducted using CFIR 2.0.ResultsAlmost half of the teams were able to implement, but only approximately one quarter with CEYP, specifically. Universal barriers that were discussed by almost all teams particularly highlighted service structures and poor resourcing as major barriers to delivery to CEYP, as well as the complexities of the young person and their network. Unique factors that differentiated teams who did and did not implement included commissioning practices, the culture of the team, leadership engagement and style, and the development of supervision structures.ConclusionsFindings offer key considerations for mental health teams, service leads, commissioners and policy‐makers to enhance delivery of best‐evidenced mental health treatments like CT‐PTSD, for CEYP.
A systematic review of immersive technologies for education: Learning performance, cognitive load and intrinsic motivation
Authors: Poupard Matisse , Larrue Florian , Sauzéon Hélène , Tricot André 
Published: July 2024

AbstractImmersive technologies are assumed to have many benefits for learning due to their potential positive impact on optimizing learners' cognitive load and fostering intrinsic motivation. However, despite promising results, the findings regarding the actual impact on learning remain inconclusive, raising questions about the determinants of efficacy. To address these gaps, we conducted a PRISMA systematic review to investigate the contributions and limitations of virtual reality (VR) and augmented reality (AR) in learning, specifically by examining their effects on cognitive load and intrinsic motivations. Through the application of an analytical grid, we systematically classified the impact of VR/AR on the causal relationship between learning performance (ie, objective learning improvement) and cognitive load or motivation, while respecting the fundamental assumptions of the main theories related to these factors. Analysing 36 studies, the findings reveal that VR, often causing extraneous load, hinders learning, particularly among novices. In contrast, AR optimizes cognitive load, proving beneficial for novice learners but demonstrating less effectiveness for intermediate learners. The effects on intrinsic motivation remain inconclusive, likely due to variations in measurement methods. The review underscores the need for detailed, sophisticated evaluations and comprehensive frameworks that consider both cognitive load and intrinsic motivation to improve understanding of the impact of immersive technologies on learning.
Practitioner notesWhat is know

Virtual and augmented reality show promise for education, but findings are inconsistent.
Existing studies suggest that augmented reality optimizes learners' cognitive load.
The literature often asserts that VR and AR are expected to enhance learning motivation.
Adding

VR introduces unnecessary cognitive load, while AR proves effective for learning performance and cognitive load, particularly for novice learners.
The impact of AR and VR on motivation to learn is unclear.
Our analytical grid offers a comprehensive framework for assessing the effects of AR and VR on learning outcomes.
Implications

AR is more suitable than VR for education concerning cognitive load.
The cost/benefit balance of VR should be carefully considered before implementation, especially for novice learners.
Rigorous studies on motivation to learn in AR and VR contexts are essential.
Prenatal diagnosis of a 15q24.1 microdeletion in a fetus with cerebral and urogenital abnormalities
Authors: Previdi Anaïk , Jordan Pénélope , Egloff Charles , Coussement Aurélie , Ahmed‐Eli Samira , Tudal Laure , Bienvenu Thierry , Picone Olivier , Dupont Jean‐Michel 
Published: July 2024

Abstract15q24.1 microdeletion syndrome is a recently described condition often resulting from non‐allelic homologous recombination (NAHR). Typical clinical features include pre and post‐natal growth retardation, facial dysmorphism, developmental delay and intellectual disability. Nonspecific urogenital, skeletal, and digit abnormalities may be present, although other congenital malformations are less frequent. Consequently, only one case was reported prenatally, complicating the genotype–phenotype correlation and the genetic counseling. We identified prenatally a second case, presenting with cerebral abnormalities including hydrocephaly, macrocephaly, cerebellum hypoplasia, vermis hypoplasia, rhombencephalosynapsis, right kidney agenesis with left kidney duplication and micropenis. Genome‐wide aCGH assay allowed a diagnosis at 26 weeks of amenorrhea revealing a 1.6 Mb interstitial deletion on the long arm of chromosome 15 at 15q24.1‐q24.2 (arr[GRCh37] 15q24.1q24.2(74,399,112_76,019,966)x1). A deep review of the literature was undertaken to further delineate the prenatal clinical features and the candidate genes involved in the phenotype. Cerebral malformations are typically nonspecific, but microcephaly appears to be the most frequent in postnatal cases. Our case is the first reported with a frank cerebellar involvement.
Spectrum of psychiatric adverse reactions to cyclin‐dependent kinases 4/6 inhibitors: A pharmacovigilance analysis of the FDA adverse event reporting system
Authors: Xiao Zhijun , Cao Jinming , Wu Shenghong , Zhou Ting , Li Canye , Duan Jingjing , Yang Zhen , Xu Feng 
Published: July 2024

AbstractBackgroundThe emergence of cyclin‐dependent kinases 4/6 inhibitors (CDK4/6i) represented a major breakthrough in the treatment of breast cancer over the past decade. In both clinical trials and real‐world settings, it was observed that patients using CDK4/6i might experience psychiatric adverse events (PAEs). Herein, we conducted a pharmacovigilance study to comprehensively assess the correlation between CDK4/6i and PAEs.MethodWe obtained individual case safety reports submitted to the FDA Adverse Events Reporting System (FAERS) during the period from January 2015 to December 2023. In disproportionality analysis, the reporting odds ratio (ROR) and information component (IC) values were calculated for each adverse event‐drug combination. Univariate logistic regression analysis was utilized to explore factors associated with PAEs following CDK4/6i treatment.ResultsA total of 95,591 reports related to CDK4/6i were identified, with 6.72% reporting PAEs, and this proportion exhibited an annual upward trend. Based on the ROR and IC values, 17 categories of PAEs were defined as CDK4/6i‐related PAEs. Among these PAEs, insomnia, stress, eating disorder, depressed mood, and sleep disorder were very common, each accounting for over 10% of CDK4/6i reports. Ribociclib showed the highest risk signal of CDK4/6i‐related PAEs (ROR = 1.89[1.75–2.04], IC025 = 0.79), followed by palbociclib (ROR = 1.47[1.41–1.53], IC025 = 0.49), while abemaciclib did not exhibit a significant signal (ROR = 0.52[0.44–0.62], IC025 = −1.13). Female sex, younger age and weight exceeding 80 kg were significant risk factors for the incidence of CDK4/6i‐related PAEs.ConclusionsUsing data from a real‐world, large‐scale spontaneous reporting system for adverse drug reactions, our study delineated the spectrum of PAEs to CDK4/6i. This potentially offered valuable insights for healthcare professionals to manage the risk of PAEs in patients receiving CDK4/6i treatment, particularly those with psychiatric disorders.
Case of a CIC::DUX4 fusion gene in a vascular neoplasm extends the spectrum of CIC‐rearranged sarcomas
Authors: Jeck William R. , Rapisardo Sarah , Anderson Barbara A. , Hendrickson Peter , Jour George , Riedel Richard F. , Brigman Brian E. , Al‐Rohil Rami N. 
Published: July 2024

AbstractCIC‐rearranged sarcomas comprise a group of exceptionally aggressive round‐cell sarcomas. These tumors most commonly demonstrate CIC::DUX4 fusion and show similar histopathology to Ewing sarcomas, though lesions mimicking vascular neoplasms have recently been described. Here, we describe a case of a patient with CIC::DUX4 fusion sarcoma identified using RNA‐based molecular testing who was initially diagnosed with an endothelial neoplasm. The tumor showed extensive vasoformative growth, complete WT1 negativity, and global positive staining for ERG, CD31, and DUX4 by immunohistochemistry. Methylation testing of the tumor clustered more closely with angiosarcomas than with CIC‐rearranged sarcomas. Our findings suggest that CIC::DUX4 fused neoplasms may demonstrate a more diverse phenotypic range than previously appreciated and offer evidence that both molecular and immunohistochemical studies are needed for accurate diagnosis.
Systematic review of disparities in continuous glucose monitoring and insulin pump utilization in the United States: Key themes and evidentiary gaps
Authors: Patel Pranav M. , Thomas Divya , Liu Zhixi , Aldrich‐Renner Sarah , Clemons Marilee , Patel Bimal V. 
Published: July 2024

AbstractAimThis study aims to provide a comprehensive overview of real‐world evidence pertaining to disparities in the utilization of continuous glucose monitors (CGMs)/insulin pumps to highlight potential evidentiary gaps and discern emerging themes from the literature.Materials and MethodsA systematic review of published manuscripts and abstracts was conducted from: MEDLINE, EMBASE, Nursing and Allied Health, Web of Science and CINHAL. Attributes related to patients, outcomes, interventions (CGMs/pumps/both) and study type were captured. In addition, factors associated with disparities in device utilization were examined.ResultsThirty‐six studies were included in the final analysis; the studies predominantly focused on people living with type 1 diabetes. Only two studies included individuals with type 2 diabetes. Almost two‐thirds of the studies reported outcomes associated with disparities (e.g. glycated haemoglobin, diabetic ketoacidosis, resource utilization). Most studies highlighted disparities across race, ethnicity and insurance type. Evidentiary gaps were identified, particularly in the evidence for people with type 2 diabetes, the continuation of CGM/pump use and limited studies addressing disparities among Native Americans/American Indians.ConclusionThis study reveals critical disparities in diabetes technology use across race, ethnicity and insurance type, particularly among people with type 1 diabetes. Evidentiary gaps assessing disparities in diabetes technology use persist, particularly concerning people with type 2 diabetes, Native American/American Indian and LGBTQ+ populations, and in outcomes related to continuation of use. Social and digital determinants of health, such as income, transportation, residential location and technological literacy, are crucial to achieving equitable access. Future research should focus on the patient journey to identify opportunities for equitable access to diabetes technology as its use grows.