bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Toxicity and Outcomes in High-risk Prostate Cancer Patients Treated With Hypofractionated IMRT and Long-term Androgen Suppression Treatment
Authors: Pervez Nadeem , Boychak Alex , Drodge Claudia S. , Yee Don , Le Duc , Murtha Albert , Parliament Matthew , Amanie John , Mihai Alina , Field Colin , Mackenzie Marc , Ghosh Sunita , Fallone Gino , Pearcey Robert 
Published: September 2014

Objective:
To assess late toxicity and outcomes in high-risk prostate cancer patients treated with hypofractionated radiation treatment with androgen suppression therapy.

Methods:
Sixty high-risk prostate cancer patients were enrolled. IMRT prescription was 68 Gy/25 fractions (2.7 Gy/fraction) to the prostate and proximal seminal vesicles (SV). The pelvic lymph nodes (PLN) and distal SV concurrently received 45 Gy/25 fractions (1.8 Gy/fraction). The patients were treated with helical TomoTherapy-based IMRT and underwent daily megavoltage CT image–guided verification before each treatment. RTOG Toxicity scores were recorded for a 5-year period.

Results:
Sixty patients completed RT with median follow-up of 63 months (range, 7 to 80 mo).
At 5 years follow-up timepoint: Grade (G)2 and G3 late genitourinary toxicity was experienced in 7 (17.0%) and 1 (2.44%), respectively; gastrointestinal G2 as highest toxicity recorded in only 1 (2.44%) patient. There was no G3 gastrointestinal toxicity recorded at this timepoint.
With 63-month median follow-up (mean of 65.41±1.72 mo), the 5-year overall survival was 86.67%; 5 years freedom from biochemical failure was 91.67% and freedom from clinical failure was 96.67%.

Conclusions:
Dose escalation and hypofractionated radiation treatment with IMRT treating the prostate and proximal SV concurrently with the pelvic lymph nodes and distal SV and long-term androgen suppression therapy is well tolerated with respect to acute and late toxicity with 5-year actuarial overall survival 86.67%, freedom from biochemical failure 91.38%, and freedom from clinical failure 96.67%. Longer follow-up will provide more information on 10-year survival outcomes.
On the correlation of CTCF binding and c-myc amplification in human prostate cancer cell lines
Authors: Fleischmann Tobias T. , Assum Günter 
Published: September 2014

2.AbstractBackgroundBackground: One of the hallmarks of prostate cancer development is the amplification ofC-MYCcopy numbers. It is not yet clear what the driving force behind the activation ofC-MYCexpression in prostate cancer is. CTCF, which is known for its role as chromatin organiser, is thought to be involved in the activation ofC-MYCexpression. The affinity of CTCF to its binding site on the DNA is negatively affected by methylation of CpG islands, including its binding site within the promoter sequences ofC-MYC. DNA hypermethylation is often found in cancer cells and could therefore be responsible for reduced binding of CTCF at theC-MYCpromoter, which can in turn lead to enhanced expression.ResultsHere, the copy number ofC-MYCof five different prostate cancer cell lines has been determined by FISH, and the state of methylation of the binding site of CTCF upstream ofC-MYCwas investigated. TheC-MYClocus was shown to be amplified to various degrees in all cell lines, reflecting the copy number of actual tumors very well, but methylation was found to remain unchanged compared to healthy cells in all examined cell lines. Hence, no correlation betweenC-MYC-copy number and CTCF binding possibilities could be established.ConclusionsThe enhanced expression ofC-MYCin prostate cancer cell lines is not affected by CTCF, whose binding presumably still persists.C-MYCactivation in prostate cancer must therefore be caused by a disparate mechanism, which also deviates from other well known mechanisms that are seen in Burkitt-Lymphoma, Leukemia and breast cancer.
Optional classification for reassembly methods with different precision remanufactured parts
Authors: Liu Mingzhou , Liu Conghu , Zhu Qinghua 
Published: September 2014

Purpose
– The purpose of this study was to research how the reassembly (remanufacturing assembly) achieves a quality that is not lower than original production with different precision remanufactured parts based on the integration of mechanics, mathematics (measurement uncertainty) and management (optional classification). Remanufactured product quality is the soul of the remanufacturing project.

Design/methodology/approach
– First, this paper studies the recycled parts features and reassembly features. Then, we build the mathematical sub-model with remanufactured parts and dimensional precision, which is proven that optional classification can effectively improve the reassembly accuracy mathematically. The optimization model of optional classification for reassembly is proposed under the constraint of a dimensional chain, and the solutions are studied based on particle swarm optimization. Finally, this method is applied in a remanufacturing enterprise and achieves good results.

Findings
– The method can reduce the cost of quality loss and improve the quality of remanufactured products.

Originality/value
– It provides a new solution and idea for reassembly with different precision remanufactured parts and promotes the healthy development of reverse logistics with a high level of customer satisfaction. This method can maximize the use of different levels of quality remanufactured parts and improve reassembly accuracy by mathematical proofs and examples.
Human factors automatic evaluation for entire maintenance processes in virtual environment
Authors: Qiu Shiguang , Yang Yunfei , Fan Xiumin , He Qichang 
Published: September 2014

Purpose
– The paper aims to propose a systematic approach for human factors (HFs) automatic evaluation for entire maintenance processes in virtual environment.

Design/methodology/approach
– First, a maintenance process information model is constructed to map real maintenance processes into computer environment. Next, based on this information model, the automatic evaluation methods for visibility, operation comfort and reachability are presented. All evaluation results are weighted and added up to establish a comprehensive HFs evaluation model. Then, the methods mentioned above are realized as an HFs evaluation module, which is integrated into virtual maintenance simulation platform, software developed by our lab.

Findings
– An application in HFs evaluation of repairing hydraulic motor on container spreader is implemented, and an on-site survey is carried out. The comparison between the result from the survey and the result we get using the presented methods shows that our solution can support HFs fast assessment accurately and effectively.

Practical implications
– Through evaluating maintenance operation processes, engineers can better analyze and validate the maintainability design of complex equipment, and some potential ergonomic issues can be found and dealt earlier.

Originality/value
– The paper contributes to present a systematic approach to achieve HFs fast and accurate evaluation for entire maintenance processes, rather than for a few maintenance postures.
How congruent are managers’ perceptions of cultural distance with objective reality?
Authors: Azar Goudarz 
Published: September 2014

Purpose– The purpose of this paper is to examine the extent to which managers’ perceptions of cultural distance – one of the most important explanatory factors in the field of international business – are congruent with objective reality.Design/methodology/approach– By subjecting a sample of 242 export ventures to correlation and confirmatory factor analyses, managers’ perceptions of the cultural distance (i.e. perceived cultural distance) between 29 international markets and Sweden (the home market) were compared, with “objective” cultural distance gauged using Hofstede's (1980) scores for dimensions of national culture.Findings– A statistically significant correlation was found between managers’ perceptions of cultural distance and “objective” cultural distance.Originality/value– Despite the importance of perceptual data in many theoretical and practical domains, few studies analyze the validity of such data. The present findings validate the congruence of perceptual data regarding cultural distance with “objective” cultural distance.
Metacognition, cultural psychological capital and motivational cultural intelligence
Authors: Gulistan Yunlu Dilek , Clapp-Smith Rachel 
Published: September 2014

Purpose– The purpose of this paper is to discuss the concept of cultural psychological capital, its impact on motivational cultural intelligence (CQ), the influence of motivational cultural intelligence on metacognitive awareness, and the moderating role of perspective taking on the relationship between motivational cultural intelligence and metacognition.Design/methodology/approach– Collected data from international management program alumni to test the hypotheses.Findings– The results show that cultural psychological capital has a positive relationship with motivational cultural intelligence, which in turn relates to metacognitive awareness, and perspective taking does not moderate the relationship between motivational cultural intelligence and metacognition.Research limitations/implications– The data were collected from a single source. The study supports broaden-and-build theory (Fredrickson, 2001) by demonstrating that cultural psychological capital has an important association with motivational cultural intelligence.Practical implications– Cultural psychological capital can be improved. Therefore, organizations that desire to increase the motivation of employees may consider improving the cultural psychological capital of employees. Learning is an important outcome of motivational cultural intelligence, and it is an asset for today's organizations.Originality/value– The study takes a positive perspective for cross-cultural experiences and identifies cultural psychological capital as an important resource for expatriates. Metacognitive awareness, as an outcome, provides support that cross-cultural experience results in higher learning for individuals who are motivated.
Social capital and national innovation system: a cross-country analysis
Authors: Ghazinoory Sepehr , Bitaab Ali , Lohrasbi Ardeshir 
Published: September 2014

Purpose– In the last two decades, researchers have paid much attention to the role of cultural values on economic and social development. In particular, the crucial role of different aspects of culture on the development of innovation has been stressed in the literature. Consequently, it is vital to understand how social capital, as a core cultural value, affects the innovation process and the innovative performance at the national level. However, to date, the impact of different dimensions of social capital and innovation has not been properly portrayed or explained. Thus, the purpose of this paper is to investigate the influence of four different dimensions of social capital (institutional and interpersonal, associational life and norms) on two of the main functions of national innovation system (NIS) (entrepreneurship and knowledge creation) based on over 50,000 observations in 34 countries.Design/methodology/approach– In this regard, national-level data from the World Values Survey database was employed to quantify social capital. Entrepreneurship is, in turn, assumed to consist of three sub-indexes and 14 indicators based on the Global Entrepreneurship Index. Knowledge creation is also measured through US Patent Office applications. Also, exploratory factor analysis and structural equation modeling approach were used to build the measurement model and investigate the impact that each factor of social capital had on entrepreneurship and knowledge application, respectively. Measurement and structural models were built and their reliability and validity were tested using various fit indices. Research findings suggest the strong positive effect of institutional trust and networking on entrepreneurship. Also, interpersonal trust and networks were shown to have high influence on knowledge development at the national level. Norms appear to have naïve to medium negative effects on both functions.Findings– Research findings suggest the strong positive effect of institutional trust and networking on entrepreneurship. Also, interpersonal trust and networks were shown to have high influence on knowledge development at the national level. Norms appear to have naïve to medium negative effects on both functions.Originality/value– However, to date, the impact of different dimensions of social capital and innovation has not been properly portrayed or explained.
Eulerian-Eulerian modelling and computational fluid dynamics simulation of wire mesh demisters in MSF plants
Authors: Al-Fulaij Hala , Cipollina Andrea , Micale Giorgio , Ettouney Hisham , Bogle David 
Published: September 2014

Purpose
– The purpose of this study is to focus on simulation of wire mesh demisters in multistage flash desalination (MSF) plants. The simulation is made by the use of computational fluid dynamics (CFD) software.

Design/methodology/approach
– A steady state and two-dimensional (2D) model was developed to simulate the demister. The model employs an Eulerian-Eulerian approach to simulate the flow of water vapor and brine droplets in the demister. The computational domain included three zones, which are the vapor space above and below the demister and the demister. The demister zone was modeled as a tube bank arrange or as a porous media.

Findings
– Sensitivity analysis of the model showed the main parameters that affect demister performance are the vapor velocity and the demister permeability. On the other hand, the analysis showed that the vapor temperature has no effect on the pressure drop across the demister.

Research limitations/implications
– The developed model was validated against previous literature data as well as real plant data. The analysis shows good agreement between model prediction and data.

Originality/value
– This work is the first in the literature to simulate the MSF demister using CFD modeling. This work is part of a group effort to develop a comprehensive CFD simulation for the entire flashing stage of the MSF process, which would provide an extremely efficient and inexpensive design and simulation tool to the desalination community.
A novel improved accelerated particle swarm optimization algorithm for global numerical optimization
Authors: Wang Gai-Ge , Hossein Gandomi Amir , Yang Xin-She , Hossein Alavi Amir 
Published: September 2014

Purpose
– Meta-heuristic algorithms are efficient in achieving the optimal solution for engineering problems. Hybridization of different algorithms may enhance the quality of the solutions and improve the efficiency of the algorithms. The purpose of this paper is to propose a novel, robust hybrid meta-heuristic optimization approach by adding differential evolution (DE) mutation operator to the accelerated particle swarm optimization (APSO) algorithm to solve numerical optimization problems.

Design/methodology/approach
– The improvement includes the addition of DE mutation operator to the APSO updating equations so as to speed up convergence.

Findings
– A new optimization method is proposed by introducing DE-type mutation into APSO, and the hybrid algorithm is called differential evolution accelerated particle swarm optimization (DPSO). The difference between DPSO and APSO is that the mutation operator is employed to fine-tune the newly generated solution for each particle, rather than random walks used in APSO.

Originality/value
– A novel hybrid method is proposed and used to optimize 51 functions. It is compared with other methods to show its effectiveness. The effect of the DPSO parameters on convergence and performance is also studied and analyzed by detailed parameter sensitivity studies.
Advancing the equality and diversity agenda in armed forces: global perspectives
Authors: Ishaq Mohammed , Maaria Hussain Asifa 
Published: September 2014

Purpose– Focusing on some of the key strands of equality and diversity (E&D), the purpose of this paper is to highlight the progress made by armed forces in implementing the E&D agenda, with specific focus on Anglophone countries and their allies. The research also looks at the obstacles encountered by managers and policymakers in attempting to establish effective diversity management in a traditionally highly conservative public sector institution.Design/methodology/approach– Using an approach known as secondary analysis, there is an in-depth review of a wide range of data sources.Findings– The analysis reveals that E&D issues in armed forces have been under researched and there is also unbalanced coverage and reporting of E&D across nations. There is also evidence of greater progress on diversity management in the armed forces of some countries but a distinct lack of progress in others. A combination of political, legal, economic and social influences are impinging on the culture of militaries. Whilst in the long-term these pressures are likely to result in armed forces becoming more reflective of developments in wider society, the road to achieving this is still fraught with uncertainty.Originality/value– To increase the understanding of diversity management in public institutions characterised by an mono culture and traditionally associated with resistance to change, and establish the extent to which the legal, social justice and business cases for promoting E&D are wholly applicable to the armed forces.
Apposition, contradiction, conflict and domination
Authors: Pynnönen Anu , Takala Tuomo 
Published: September 2014

Purpose
– The purpose of this paper is to qualitatively describe and explain the contemporary Finnish discourse of municipal managers. The emphasis within is on analyzing the encounters of the public sector management discourse and the private sector management discourse, and the effects that these encounters have on the construction and representation of municipal management.

Design/methodology/approach
– The study is based on a three-phase discourse analysis, proceeding from the textual and linguistic level through interpretive analysis to critical analysis. This analysis is based on the proceedings and presentations of a seminar of municipal leadership and management, arranged in 2013 in Finland.

Findings
– The encounters of the discourses form three types: apposition of actors; contradiction and conflict of contexts; and domination of the private sector discourse. Apposition is a surface-level phenomenon, synonymizing the actors of the two discourses. Contradiction and conflict are caused by the incompatibility of operational and value contexts. Domination is a phenomenon of prioritizing the private sector principles and values in conflict situations. All these may affect the role and work of, as well as expectations toward, the municipal manager.

Research limitations/implications
– Further research and more samples are needed to assess wider applicability of the present findings.

Originality/value
– The study highlights the roles of language and discourse in the construction and representation of municipal management and managers. It increases the importance of understanding the discursive elements of the new public management phenomenon. In addition, the study supplements the existing macro-level studies.
Consumer characteristics and social influence factors on green purchasing intentions
Authors: Wang Shih-Tse 
Published: September 2014

Purpose– Green consumer behavior has recently attracted the attention of academic researchers. To address a lack of relevant research, the effects that consumer characteristics (i.e. external locus of control and collectivism) and social influence factors (i.e. environmental visibility and subjective norms) exert on green purchasing intentions are investigated in this study. The paper aims to discuss these issues.Design/methodology/approach– Data were collected through a quantitative online survey of 1,866 participants in Taiwan, and structural equation modeling (SEM) was used to analyze the data.Findings– The results show that although an external locus of control exerted a negative effect on consumers’ green consumption intentions, collectivism values exerted a positive influence. In addition, both environmental visibility and subjective norms exerted a significant effect on green purchasing intentions.Originality/value– Consumer characteristics and social influence factors were integrated into green consumer research in this study. The findings can improve green market managers’ understanding of the role that consumer characteristics and social influence factors play in consumer decisions.
Integrating corporate social responsibility into efforts to realize millennium development goals
Authors: Katamba David , Marvin Nkiko Cedric , Tushabomwe-Kazooba Charles , Babiiha Mpisi Sulayiman , Kemeza Imelda , M.J. Wickert Christopher 
Published: September 2014

Purpose– The purpose of this paper is to present corporate social responsibility (CSR) as an alternative roadmap to accelerating realization of Millennium Development Goals (MDGs) in Uganda, even after 2015.Design/methodology/approach– Using a mixed research methodology, this research documented CSR activities of 16 companies operating in Uganda. Data collection was guided by quantitative and qualitative methodologies (semi-structured interviews with CSR managers, plus non-participant observation of CSR activities and projects linked with MDGs). Triangulation was used to ensure credibility and validity of the results. For data analysis, the authors followed a three-stepwise process, which helped to develop a framework within which the collected data could be analyzed. For generalization of the findings, the authors were guided by the “adaptive theory approach”.Findings– Uganda will not realize any MDGs by 2015. However, CSR activities have the potential to contribute to a cross-section of various MDGs that are more important and relevant to Uganda when supported by the government. If this happens, realization of the MDGs is likely to be stepped up. CSR's potential contributions to the MDGs were found to be hindered by corruption and cost of doing business. Lastly, MDG 8 and MDG 3 were perceived to be too ambiguous to be integrated into company CSR interventions, and to a certain extent were perceived to be carrying political intentions which conflict with the primary business intentions of profit maximization.Practical implications– Governments in developing countries that are still grappling with the MDGs can use this research when devising collaborations with private-sector companies. These documented CSR activities that contribute directly to specific MDGs can be factored into the priority public-private partnership arrangements. Private companies can also use these findings to frame their stakeholder engagement, especially with the government and also when setting CSR priorities that significantly contribute to sustainable development.Originality value– This research advances the “Post-2015 MDG Development Agenda” suggested during the United Nations MDG Summit in 2010, which called for academic and innovative contributions on how MDGs can be realized even after 2015.