bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survivorship of total knee arthroplasty in poliomyelitis patients: long-term results from the R.I.P.O. registry and single-institution retrospective study
Authors: Manzetti Marco , Digennaro V. , Di Martino A. , Bordini B. , Benvenuti L. , Ferri R. , Cecchin D. , Faldini C. 
Published: July 2024

Abstract
Introduction
The survival of total knee arthroplasty (TKA) in patients with poliomyelitis remains a debated topic due to the high recurrence of postoperative genu recurvatum. This study aims to report the long-term survival of TKA in patients with poliomyelitis, using data from the Italian Register of Prosthetic Implantology.

Materials and methods
A registry-based population study was conducted, utilizing data from the Emilia Romagna orthopedic arthroplasty implants registry (RIPO - Registro Implantologia Protesica Ortopedica). The cohort consisted of 71 patients with poliomyelitis-related arthritis who underwent TKA. The study assessed and analyzed demographic data, implant type, fixation method, insert type, and level of constraint. Additionally, variations in preoperative and postoperative both clinical and functional Knee Society Scores (KSS) were collected.

Results
Eight implants required revision surgery (16%), and three patients died (6.1%), resulting in a 10-year survival rate of 86.6% and a 15-year survival rate of 53.9%. Aseptic loosening was the primary cause of revision, accounting for 37.5% of failures, followed by insert wear (25%). No statistically significant correlation was found between the level of constraint and implant survival (p=0.0887, log-rank). Both the clinical and functional KSS improved postoperatively.

Conclusion
TKA is a viable alternative to knee arthrodesis and, in properly selected patients, might represent the first-choice treatment for articular degeneration due to its high survivorship. Despite the complexity of these cases, TKA can effectively alleviate articular pain, instability, and angular deviation, thereby preserving knee functionality.
Cancer and immune response: The role of PD-1/PD-L1 checkpoint in laryngeal carcinoma. Preliminary results
Authors: Verro Barbara , Saraniti Giuseppe , Ottoveggio Gaetano , Saraniti Carmelo 
Published: July 2024

Abstract
Purpose
The overall survival of laryngeal squamous cell carcinoma (LSCC) hasn’t changed significantly in the last decades, leading to a negative prognosis in advanced stages. So, the immunotherapy takes space with the inhibition of PD-1/PD-L1 checkpoint, involved in suppression of immune response.

Methods
A prospective study was conducted on LSCC patients, selected according to strict criteria. The study was approved by the ethics committee of our Hospital. Parameters were: sex, age, smoking and alcohol habits, C-reactive protein (CRP) level in the serum, laryngeal subsite involved, differentiation-based histopathologic grading of tumor, neck node involvement, tumor stage, expression levels of PD-L1 (as Combined Positive Score – CPS). P-value < 0.05 was statistically significant.

Results
58 patients were included: 31.03% were females, mean age 63.55±10.09. A statistically significant correlation between CPS and smoking habits and N stage was found. CRP resulted increased in 44.83% of patients with a statistically significant correlation with CPS. The most cases were glottic cancers (46.55%). 75.86% of tumors were moderately-differentiated, without correlation with CPS.

Conclusion
PD-L1 expression levels are variables independent of sex, age, alcohol consumption, differentiation degree of LSCC. A statistically significant correlation between PD-L1 expression levels and smoking habits, neck node status and CRP was found. This last finding demonstrates the involvement of PD-1/PD-L1 checkpoint in immune response in case of cancer. However, these results need further studies to detect the best patients tailored for treatment with anti-PD-1/PD-L1 blocking antibodies.
Performance of hybrid gain formula versus traditional fitting formulas in hearing aid fitting in tinnitus patients with hearing loss
Authors: Sendesen Eser , Colak Hasan 
Published: July 2024

Abstract
Purpose
Hearing aid fitting can be challenging when tinnitus accompanies hearing loss, as speech intelligibility and quality of life are affected by both hearing loss and tinnitus perception. However, studies focusing on the optimal hearing aid fitting for this group are scarce. Here, we aim to investigate the performance of alternative hearing aid fitting scenarios in improving hearing aid benefit and managing tinnitus.

Methods
Sixty-six participants were included in the study and randomly divided into three groups based on the fitting formula: NAL-NL2, DSL pediatric and hybrid gain fitting procedure (covering NAL-NL2 for low frequencies and DSL pediatric formulas for high frequencies). Hearing aid benefit was evaluated using the Abbreviated Profile of Hearing Aid Benefit (APHAB) questionnaire and speech perception in noise (SPIN). To evaluate tinnitus perception, psychoacoustic characteristics of tinnitus were determined, and the Tinnitus Handicap Inventory (THI) was gathered.

Results
The NAL-NL2 fitting procedure showed better results in hearing aid benefit and SPIN compared to the DSL pediatric procedure. In the DSL pediatric procedure, better results were obtained in tinnitus management compared to NAL-NL2. There was no difference between the hybrid fitting procedure and DSL pediatric in tinnitus management. The hybrid fitting procedure also did not differ from NAL-NL2 in SPIN and hearing aid benefit.

Conclusion
Here, we propose a hybrid gain fitting procedure that can be a better alternative to boost hearing aid performance and tinnitus management in clinical practice.
Management of uncontrolled/recurrent epistaxis by ligation or cauterization of the sphenopalatine artery: a scoping review
Authors: Dispenza Francesco , Lorusso Francesco , Di Vincenzo Salvatore Alberto , Dolce Anita , Immordino Angelo , Gallina Salvatore , Maniaci Antonino , Lechien Jerome Rene , Calvo-Henriquez Christian , Saibene Alberto Maria , Sireci Federico 
Published: July 2024

Abstract
Purpose
The control of epistaxis has always posed a significant challenge for otolaryngologists. One of the most viable options to address refractory cases is the ligation or cauterization of the sphenopalatine artery. The objective of this study was to assess the efficacy, safety, and long-term outcomes of these interventions.

Materials and methods
Two independent otolaryngologists conducted a comprehensive search for studies dealing with management of uncontrolled/recurrent epistaxis by consulting the main scientific databases on the web, including PubMed, Google Scholar, Medline, EMBASE, Web of Science, and the Cochrane Library. The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. The criteria for considering studies for the review were based on the population, intervention, comparison, outcome, timing and setting (PICOTS) framework.

Results
Sixteen studies were included in the systematic review, comprising a total of 454 patients. Among these, 289 individuals underwent ligation of the sphenopalatine artery, while 100 underwent cauterization of the same artery. Additionally, 56 patients underwent both ligation and cauterization of the sphenopalatine artery during the same surgery. The incidence of rebleeding and complications was respectively 12.1% (55/454) and 3% (14/454), resulting in relatively low rates in both cases.

Conclusions
Our review emphasizes the increasing importance of surgical approaches, specifically ligation or cauterization of the sphenopalatine artery, in addressing refractory cases. The low incidence of complications, predominantly temporary decreased lacrimation in patients undergoing ligation of the sphenopalatine artery, highlights the safety and feasibility of these interventions.
Alcohol-associated liver disease increases the risk of muscle loss and mortality in patients with cirrhosis
Authors: Hanai Tatsunori , Nishimura Kayoko , Unome Shinji , Miwa Takao , Nakahata Yuki , Imai Kenji , Suetsugu Atsushi , Takai Koji , Shimizu Masahito 
Published: July 2024

Abstract
Background
Rapid skeletal muscle loss adversely affects the clinical outcomes of liver cirrhosis. However, the relationships between the annual changes in skeletal muscle area (ΔSMA/year) and the etiology of cirrhosis, factors associated with muscle loss, and risk of mortality remains unclear.

Methods
A total of 384 patients who underwent multiple computed tomography (CT) scans between March 2004 and June 2021 were enrolled in this study (median age, 67 years; 64% men; median model for end-stage liver disease score, 9). Body composition and ΔSMA/year were estimated using a 3D image analysis system and data from at least two distinct CT scans. Differences in ΔSMA/year among different etiologies of cirrhosis, factors associated with rapid muscle loss (defined as ΔSMA/year ≤  − 3.1%), and the association between ΔSMA/year and mortality were examined.

Results
Patients with alcohol-associated liver disease (ALD) cirrhosis experienced more rapid muscle loss (ΔSMA/year, − 5.7%) than those with hepatitis B (ΔSMA/year, − 2.8%) and hepatitis C cirrhosis (ΔSMA/year, − 3.1%). ALD cirrhosis was independently associated with ΔSMA/year ≤  − 3.1% after adjusting for age, sex, and liver functional reserve. Over a median follow-up period of 3.8 years, ALD cirrhosis, ΔSMA/year ≤  − 3.1%, and low subcutaneous adipose tissue level were found to be significantly associated with reduced survival. ALD cirrhosis (hazard ratio [HR], 2.43; 95% confidence interval [CI] 1.12–5.28) and ΔSMA/year ≤  − 3.1% (HR, 3.68; 95% CI 2.46–5.52) were also predictive of mortality.

Conclusions
These results suggest that ALD cirrhosis increases the risk of rapid muscle loss and mortality in affected patients.
The role of tissue IgG4 levels in steroid therapy in patients with idiopathic granulomatous mastitis
Authors: Seyidli Celil , Aydoğdu Yunushan Furkan , Büyükkasap Çağrı , Kozan Ramazan , Nasirov Mahir , Dikmen Kürşat , Esendağli Yilmaz Güldal , Akin Murat 
Published: July 2024

AbstractIdiopathic granulomatous mastitis (IGM) is a benign, chronic inflammatory lesion of the breast. Immunoglobulin G4 (IgG4) associated disease is rare in the breast. In our study, we aimed to evaluate the efficacy of steroid treatment on IgG4 levels in tissue in patients diagnosed with IGM. Between 2008 and 2017, 55 patients diagnosed with IGM in our clinic were included in the study. Demographic, clinical, microbiologic and histopathologic characteristics, treatment modality and recovery time were evaluated retrospectively. Patients were divided into 3 groups according to tissue IgG4 levels: negative (Group I), infrequently and slightly positive (Group II), and highly positive (Group III). Group I patients had a complete response rate of 77.8%. In the rest of the patients (22.2%), insufficient response was detected from the beginning of the treatment. In Group II, the response rate was 91.3% and the permanent success rate after treatment was 87.0%. Although group III patients had a complete response at the beginning (95.65%), they relapsed in a short period of time (26.1%) after discontinuation of steroid treatment. At least one steroid-related side effect was observed in 47 (85.8%) patients in all groups. There is no consensus on the dose and duration of immunosuppressive treatment in IGM. In this study, responses to steroid treatment according to IgG4 concentration in pathologic breast tissue and recurrences after the end of treatment were determined. We think that high IgG4 concentration in the tissue is associated with recurrence and other immunosuppressive drugs should be added as maintenance after steroid treatment.
Towards a process selection method for embedded analytics
Authors: Bender Tobias 
Published: July 2024

AbstractDriven by technological progress, business analytics is gaining momentum while paving the path for next-generation business process management. Especially, embedded real-time analytics offers new opportunities for business process intelligence and value creation. However, there are several obstacles that organizations face in their adoption process. A key challenge is to identify business processes that are suitable for embedded analytics and hold relevant value potential. Our research addresses this need by introducing an exploratory BPM method, namely a process selection method. Applying action design research and situational method engineering, we iteratively built, used, evaluated, and refined the theory-ingrained method artifact. The method provides organizations with guidance in selecting operational business processes, for which a reengineering project should be initiated.
Strong activation of p53 by actinomycin D and nutlin-3a overcomes the resistance of cancer cells to the pro-apoptotic activity of the FAS ligand
Authors: Łasut-Szyszka Barbara , Gdowicz-Kłosok Agnieszka , Krześniak Małgorzata , Głowala-Kosińska Magdalena , Będzińska Agnieszka , Rusin Marek 
Published: July 2024

AbstractThe FAS ligand (FASLG) is expressed on lymphocytes, which employ it to activate death receptors on target cells. Cancer cells are generally resistant to apoptosis triggered by FASLG. In this work, we found a way to circumvent this resistance by treatment with actinomycin D (ActD) and nutlin-3a (Nut3a). We selected this drug combination based on our transcriptomic data showing strong activation of proapoptotic genes, including those for receptor-mediated apoptosis, in cells exposed to actinomycin D and nutlin-3a. To test our hypothesis, we pre-exposed cancer cell lines to this drug combination for 45 h and then treated them with recombinant FASLG. This almost instantaneously killed most cells. Actinomycin D and nutlin-3a strongly cooperated in the sensitization because the effect of the drugs acting solo was not as spectacular as the drug combination, which together with FASLG killed more than 99% of cells. Based on the caspase activation pattern (caspase-8, caspase-9, caspase-10), we conclude that both extrinsic and intrinsic pro-apoptotic pathways were engaged. In engineered p53-deficient cells, this pro-apoptotic effect was completely abrogated. Therefore, the combination of ActD + Nut3a activates p53 in an extraordinary way, which overcomes the resistance of cancer cells to apoptosis triggered by FASLG. Interestingly, other combinations of drugs, e.g., etoposide + nutlin-3a, actinomycin D + RG7112, and actinomycin D + idasanutlin had a similar effect. Moreover, normal human fibroblasts are less sensitive to death induced by ActD + Nut3a + FASLG. Our findings create the opportunity to revive the abandoned attempts of cancer immunotherapy employing the recombinant FAS ligand.
Graphical Abstract
Screening of heat stress-tolerant weedy rice and SNP identification of heat-tolerance-related genes
Authors: Sarker Mainul Hasan , Hussain Md Hamed , Neik Ting Xiang , Hasan Md Zobaer , Wee Wei Yee , Tan Hock Siew , Ko Swee-suak , Song Beng-Kah 
Published: July 2024

AbstractRice, a staple crop that feeds more than one-third of the world’s population, encounters a wide range of biotic and abiotic stresses due to climate change. Rising temperature is one of the significant abiotic stresses affecting rice productivity worldwide. The development of heat-tolerant rice cultivars is critical in this regard. Weedy rice could potentially serve as a natural resource for genes conferring agronomically important traits beneficial to cultivated rice. However, heat tolerance in both cultivated and weedy rice is still understudied. This study screened a set of 180 weedy rice accessions for heat stress tolerance and further characterised them using genome-wide single-nucleotide polymorphisms (SNPs) analysis. Five heat-tolerant (HT) accessions (MU244, MU235, MU249, MU260 and MU237), along with five heat-susceptible (HS) accessions (MU100, MU114, MU264, MU251 and MU005), were subjected to relative electrical conductivity (REC) test and reactive oxidative species assay (ROS). These tests verified that the five HT accessions performed better under heat stress than their HS counterparts. In addition, whole-genome sequences of three HT (MU235, MU237 and MU066) and four HS (MU100, MU114, MU022 and MU005) accessions were selected for the genome-wide SNPs comparison, revealing substantial amino acid variation in the heat-tolerance-related genes between the HT and HS rice groups. The proposed genes and genome-wide SNP markers may help rice breeders better understand how different rice cultivars respond to heat stress.
Lifestyle Intervention in Reducing Insulin Resistance and Preventing type 2 Diabetes in Asia Pacific Region: A Systematic Review and Meta-Analysis
Authors: Cao Yingting , Shrestha Abha , Janiczak Amy , Li Xia , Lu Yang , Haregu Tilahun 
Published: July 2024

Abstract
Purpose of Review
To update the evidence of lifestyle interventions for the prevention of type 2 diabetes mellites (T2DM) in adults, particularly in the Asia Pacific region. The key questions to ask are: 1) How effective are lifestyle interventions in preventing T2DM among at-risk adults in the Asia Pacific Region? 2)What are the key characteristics of the implementation of lifestyle interventions for diabetes prevention?

Recent Findings
Lifestyle interventions for the prevention of T2DM have been suggested to be effective. There is evidence of ethnic differences in some glycaemic and anthropometric outcomes.

Summary
The meta-analysis suggested a significant result in reducing waist circumference (standardised mean difference − 019, 95%CI ( -0.31, -0.06)), and no significant effects in other outcomes. However, the implementation outcomes suggested lifestyle intervention might be a cost-effective and sustainable approach in T2DM particularly in countries in the Asia Pacific Region. The focus of lifestyle intervention in the Asia Pacific Region should not only lie in the effectiveness of the trial but a thorough evaluation of the implementation outcomes, as well as cultural adaptations, with the support of all stakeholders through all stages of the implementation.
The Roles of Asylum Seeker–Led Organisations in Settlement Processes and Determinants: Evidence from Hong Kong
Authors: Lam Ka Wang Kelvin 
Published: July 2024

AbstractOrganisations led by refugees or migrants play an important role in their settlement, providing platforms for establishing connections and reaching the wider community. However, our knowledge of how they utilise these platforms for establishing connections and the factors affecting the formation of these connections remains limited. This paper, drawing on evidence from Hong Kong, examines the use of organisations led by asylum seekers as platforms for establishing connections, the roles of these connections in their settlement process, and the factors affecting the formation of these connections. Data were collected from an asylum seeker–led organisation in Hong Kong. The author conducted participant observation and 30 semi-structured interviews with adult asylum seekers while volunteering with this organisation between 2018 and 2021. The findings reinforce the importance of organisations led by refugees or migrants in their settlement process, particularly when official humanitarian aid is insufficient. They utilise these platforms to reach the wider community for support, thereby filling assistance gaps through establishing connections with the local community (bridging) and participating in policy advocacy activities (linking). Proficiency in the local language and institutional responsiveness were found to determine their ability to bridge with the local community and link with policymakers respectively. Overall, the findings suggest that, aside from the engagement of refugees or migrants, the support of host communities and institutional responsiveness are equally important in creating favourable conditions for them to adjust to and establish their lives in a new context.
Teacher Stereotypes and Teacher Expectations at the Intersection of Student Gender and Socioeconomic Status
Authors: Gentrup Sarah , Olczyk Melanie , Lorenz Georg 
Published: July 2024

Abstract: Gender and family socioeconomic status (SES) are central dimensions of educational inequality and may interact in shaping inequality. This study addresses teacher expectations and stereotypes that possibly contribute to intersectional inequality. The study relies on two samples of teachers and students in German primary schools (sample 1: NTeachers=69, 94 % female, NStudents= 1,049 (German language)/1,027 (mathematics), 48 % female; sample 2: NTeachers= 698 (German language)/614 (mathematics), 94 % female; NStudents= 4,732 (German language)/4,117 (mathematics), 51 % female). Two-level regression analyses revealed additive gender and socioeconomic bias in teacher expectations in German language and mathematics but no intersectional bias (i. e., constant gender bias along family SES and similar socioeconomic bias for girls and boys). Further, teachers with more traditional gender stereotypes showed stronger gender bias, while SES-related stereotypes were unrelated to teacher expectations. We discuss how additive teacher expectation biases relate to the broader concept of intersectionality, potentially shaping unique educational experiences at the intersection of gender and SES.
Slip‐Dependence of Fault Frictional Stability Under Hydrothermal Conditions
Authors: Feng Wei , Yao Lu , Gomila Rodrigo , Ma Shengli , Pennacchioni Giorgio , Di Toro Giulio 
Published: July 2024

AbstractIn the rate‐state friction law framework, the transition from velocity weakening (V‐W) to velocity strengthening (V‐S) behavior marks the base of the seismogenic crust. Here we investigate the role of fault slip displacement under hydrothermal conditions in controlling the V‐W to V‐S transition. We shear simulated gabbro gouges at slip velocities ranging from 16 nm/s (∼50 cm/year) to 10 μm/s (∼8 cm/day) under hydrothermal conditions (300–400°C temperature; 30 MPa pore fluid pressure). We observe that cumulative fault slip increases the critical velocity for the V‐W to V‐S transition. The transition is accompanied by localized to distributed deformation mode, the formation of smectite‐type clays and occurrence of intergranular mass transfer. Our results provide insights into understanding the deepening and shallowing of V‐W/V‐S boundary (lower limit of the seismogenic zone) following a mainshock. Besides strain rate effects, slip‐enhanced chemical alteration and grain size‐sensitive deformation may temporarily contribute to the shallowing process.