bluuebunny/crossref_metadata_2025_split huggingface dataset:
The puzzle of mood rationality
Authors: Bradley Adam 
Published: July 2024

AbstractMoods, orthodoxy holds, exist outside the space of reasons. A depressed subject may change their thoughts and behaviors as a result of their depression. But, according to this view, their mood gives them no genuine reason to do so. Instead, moods are mere causal influences on cognition. The issue is that moods, with their diffuse phenomenology, appear to lack intentionality (Directionlessness). But intentionality appears to be a necessary condition on rationality (The Content Constraint). Together, these principles conflict with the idea that moods are rational states of mind (Mood Rationality). The inconsistency of these three principles is the Puzzle of Mood Rationality. Now to many, this puzzle is hardly vexing: we should reject Mood Rationality. But, I argue, Mood Rationality is true despite its unpopularity. Thus, we need another way of resolving the puzzle. To do so, I distinguish intentionality as a first‐personal, phenomenological notion from representation as a third‐personal, cognitive scientific notion. I then argue that moods satisfy a revised version of the Content Constraint and sketch an account of moods as representational but non‐intentional mental states, drawing on the Valuationist paradigm in affective neuroscience. I end by showing how this account enables us to explain moods’ rationality.
Association between ultraprocessed food consumption and excess adiposity in children and adolescents: A systematic review
Authors: Robles Brenda , Mota‐Bertran Anna , Saez Marc , Solans Marta 
Published: July 2024

SummaryUltraprocessed foods (UPF) consumption is associated with excess adiposity in adults, but this linkage remains unclear among children and adolescents. The present systematic review sought to address this research gap. Publications up to November 2023 were retrieved from PubMed, Web of Science, and Scopus databases. Outcomes included overweight/obesity anthropometric and body composition indicators; the exposure was UPF consumption based on the NOVA classification system. The review included 23 studies (i.e., 8 cohort and 15 cross‐sectional); approximately half were carried out in Brazil. Inconclusive and heterogeneous evidence exists as few cohort studies found positive/mixed associations between UPF consumption and excess adiposity in pediatric populations, whereas most cross‐sectional studies reported null associations. Such inconsistencies may be attributed to underlying methodological issues, especially heterogeneity in the outcomes assessed and UPF consumption operationalization and/or categorization. Future studies should adopt longitudinal designs with sufficiently extended follow‐up periods, account for relevant confounding factors, employ validated and standardized measurement tools to assess dietary exposure, ensure consistent operationalization of variables, and encompass diverse geographic contexts. Ultimately, strengthening the quality of existing research evidence may better inform current and forthcoming policy and practice interventions aimed at mitigating the increasing prevalence of overweight/obesity in childhood and across the life course.
Quantitative risk assessment for the introduction of bluetongue virus into mainland Europe by long‐distance wind dispersal of Culicoides spp.: A case study from Sardinia
Authors: Bibard Amandine , Martinetti Davide , Giraud Aymeric , Picado Albert , Chalvet‐Monfray Karine , Porphyre Thibaud 
Published: July 2024

AbstractEurope faces regular introductions and reintroductions of bluetongue virus (BTV) serotypes, most recently exemplified by the incursion of serotype 3 in the Netherlands. Although the long‐distance wind dispersal of the disease vector, Culicoides spp., is recognized as a virus introduction pathway, it remains understudied in risk assessments. A Quantitative Risk Assessment framework was developed to estimate the risk of BTV‐3 incursion into mainland Europe from Sardinia, where the virus has been present since 2018. We used an atmospheric transport model (HYbrid Single‐Particle Lagrangian Integrated Trajectory) to infer the probability of airborne dispersion of the insect vector. Epidemiological disease parameters quantified the virus prevalence in vector population in Sardinia and its potential first transmission after introduction in a new area. When assuming a 24h maximal flight duration, the risk of BTV introduction from Sardinia is limited to the Mediterranean Basin, mainly affecting the southwestern area of the Italian Peninsula, Sicily, Malta, and Corsica. The risk extends to the northern and central parts of Italy, Balearic archipelago, and mainland France and Spain, mostly when maximal flight duration is longer than 24h. Additional knowledge on vector flight conditions and Obsoletus complex‐specific parameters could improve the robustness of the model. Providing both spatial and temporal insights into BTV introduction risks, our framework is a key tool to guide global surveillance and preparedness against epizootics.
Untangling spatio‐temporal dynamics and determinants of technology transfer from a patent assignment perspective: The case of China's AI data
Authors: Zeng Wen , Wang Yuefen , Ba Zhichao , Cen Yonghua 
Published: July 2024

AbstractThis study delves into the spatio‐temporal dynamics and influencing mechanisms of technology transfer. Leveraging graph theory, we constructed a patent transfer network to understand its evolving patterns. We redefined technology transfer types, analyzed transition probabilities through Markov chain, and summarized their temporal and spatial shifts. Incorporating spatial and nonspatial methods, we explored the heterogeneity of key drivers, such as GDP and internal R&D expenditures, across regions. Our findings reveal that China's AI technology transfer network transformed from sparse to densely interconnected, with transfer types evolving from singular to diversified directions and objects. Provinces often maintain stability or transition to adjacent types, forming agglomerations of similar transfer types. GDP and internal R&D expenditures emerge as key drivers, exerting distinct impacts across regions. This study offers insights to enterprises and policymakers in developing tailored strategies for promoting technology transfer.
Digital Twin Applied to Predictive Maintenance for Industry 4.0
Authors: Kerkeni Rochdi , Khlif Safa , Mhalla Anis , Bouzrara Kais 
Published: July 2024

Abstract
The major concept of the future Industrial 4.0 framework is the integration of artificial intelligence (AI) and the implementation of digital twin (DT), which avoids serious economic losses caused by unexpected equipment failures and significantly improves system reliability. DT is an emerging technology in the context of digital transformation that enables the monitoring, diagnosis, energy efficiency, and optimization of different systems. Numerous initiatives have shown how AI can enhance the performance of DT for industrial applications. This paper describes a data-based DT architecture for the monitoring, and predictive maintenance (PdM) in manufacturing. This new concept is based on deep learning, specifically the autoencoder model. The system was tested on a real industry example, by developing the data collection, data system analysis, and applying the deep learning approach. The data were collected from a Profinet communication network installed on an automated system. This approach enables better quality results and more efficient management of the weaver's workshop. Lastly, to prove the efficiency and the accuracy of the newly developed approach, an example is shown.
Resolving the “megacryst paradox”: Feldspar orientation relationships record crystal mobility in granites
Authors: Gordon Charlotte , Wallis David 
Published: July 2024

Abstract
K-feldspar megacrysts are common in silicic plutons, but there is a long-running debate around how they form and what their presence tells us about magmatic systems. Field, textural, and geochemical evidence supports growth in a melt-rich environment, but experimental evidence and phase-equilibria modeling indicate that K-feldspar grows late in the crystallization sequence, when the magma is highly crystalline. We provide a new perspective on this problem by examining the arrangement of plagioclase inclusions within megacrysts to test whether they exhibit the systematic low-energy crystallographic relationships expected from attachment by synneusis in melt-rich environments where crystals have space to rotate. We use electron backscatter diffraction to quantify the crystal orientations and find that the megacrysts’ plagioclase inclusions do occupy these preferred orientations and therefore were incorporated in a melt-rich environment. K-feldspar is also present as an interstitial network, but plagioclase crystals hosted within this network have non-systematic orientations. This transition from systematic to non-systematic plagioclase orientations marks the point at which the crystals formed a rigid, interconnected framework that impeded rotation into low-energy orientations. Phase-equilibria modeling indicates that this transition occurred when the magma was ~55% crystalline. The remaining ~45% melt crystallized at the eutectic, forming the interstitial phases. Thus, we resolve the “megacryst paradox”; the megacrysts grew freely in melt, and the groundmass K-feldspar formed after crystal lock-up. Megacrysts therefore provide a detailed textural and chemical record of a critical period in the system’s evolution: the transition from a mobile and potentially eruptible magma to an immobile mush.
Treatment outcomes in the inpatient management of severe functional neurological disorder: a retrospective cohort study
Authors: Saunders Chloe , Bawa Hetashi , Aslanyan Daron , Coleman Frances , Jinadu Helen , Sigala Natasha , Medford Nick 
Published: July 2024

BackgroundFunctional neurological disorder (FND) is a heterogeneous condition; severe forms can be disabling. Multidisciplinary treatment and rehabilitation are recommended for severe FND, but there remains a lack of evidence for its efficacy and lack of understanding of the predictors and components of recovery.MethodsWe report clinical outcome data for an inpatient cohort with severe FND. Clinical Global Impression Improvement with treatment is the primary outcome measure. Admission and discharge measures (Euroqol quality of life measures, Beck Depression Inventory, Spielberger Trait Anxiety Inventory, Cambridge Depersonalisation Scale, Illness Perception Questionnaire (Revised) and Functional Mobility Scale) are reported as secondary outcomes.ResultsWe describe an FND cohort (n=52) with chronic illness (mean symptom duration 9.7 years). At admission, there were clinically relevant levels of depression, anxiety and depersonalisation derealisation. At the time of discharge, most (43/52) patients’ global condition had improved. Measures of mobility, depression and quality of life also significantly improved while at discharge, symptoms were experienced as more understandable and less distressing than at admission. An admission measure of patient confidence in treatment was predictive of eventual clinical outcome.ConclusionsThe most frequent outcome of inpatient rehabilitation is global improvement, even when symptoms are chronic and severe, reflected in measurable changes in both physical and psychological functioning. Significant levels of depersonalisation derealisation seen in this patient group suggest that routine enquiry into such experiences could help personalise FND treatment approaches. Patient confidence in treatment is key in determining clinical outcomes.
Effect of ripasudil after trabeculectomy with mitomycin C: a multicentre, randomised, prospective clinical study
Authors: Muhlisah Aisyah , Hirooka Kazuyuki , Nurtania Ariyanie , Onoe Hiromitsu , Okumichi Hideaki , Nitta Eri , Baba Tetsuya , Tanito Masaki , Matsuoka Yotaro , Nakakura Shunsuke , Kiuchi Yoshiaki 
Published: July 2024

BackgroundTo investigate if there are improvements in trabeculectomy outcomes supporting filtration bleb formation caused by Rho-associated protein kinase (ROCK) inhibitors.MethodsThis prospective, multicentre, randomised, open-label clinical study examined open-angle glaucoma patients who underwent trabeculectomy or trabeculectomy combined with cataract surgery followed by 3-month postoperative ripasudil treatments. After randomly allocating patients to ripasudil—ROCK inhibitor (ripasudil) or without ripasudil (non-ripasudil) groups. Mean intraocular pressure (IOP) changes, success rate, and number of eyedrops were compared for both groups.ResultsA total of 17 and 15 subjects dropped out in the ripasudil group and non-ripasudil group, respectively. At baseline, the mean IOP was 16.8±5.0 mm Hg in the ripasudil group (38 patients) and 16.2±4.4 in the non-ripasudil group (52 patients). The IOP decreased to 11.4±3.2 mm Hg, 10.9±3.9 mm Hg and 10.6±3.5 mm Hg at 12, 24 and 36 months in the ripasudil group, while it decreased to 11.2±4.1 mm Hg, 10.5±3.1 mm Hg and 10.9±3.2 mm Hg at 12, 24 and 36 months in the non-ripasudil group, respectively. There was a significant decrease in the number of IOP-lowering medications after trabeculectomy in the ripasudil group versus the non-ripasudil group at 24 (p=0.010) and 36 months (p=0.016). There was no statistically significant difference between the groups for the 3-year cumulative probability of success.ConclusionAlthough ripasudil application did not increase the primary trabeculectomy success rate, it did reduce IOP-lowering medications after trabeculectomy with mitomycin C.
Evaluating and mapping the evidence that screening for diabetic foot disease meets the criteria for population-wide screening: a scoping review
Authors: Pallin Jennifer A , Connell Lauren , McIntosh Caroline , Kavanagh Paul , Dinneen Sean F , Kearney Patricia M , Buckley Claire M 
Published: July 2024

ObjectiveTo evaluate and map the evidence around diabetes-related foot screening using the World Health Organisation screening principles, which set the gold standard for determining the appropriateness of introducing population-wide screening programmes internationally.DesignA scoping review methodology in line with Arksey and O’Malley and the Joanna Briggs Institute.Data sourcesMedline (EBSCO), Scopus, ScienceDirect and EMBASE between 24 May 2022 and 12 July 2022. Reference lists of the selected studies, and ‘Google’ and ‘Google Scholar’ were also searched.Eligibility criteriaInclusion criteria were informed by the principles of screening. Articles, published in English since 2000, reporting on the impact of the diabetes-related foot ulcers, effectiveness of treatment available for those identified as being at risk, reliability of screening tests for screening for the at-risk foot and the effectiveness, cost-effectiveness, safety and ethics of diabetes-related foot screening programmes were included.Data extraction and synthesisData were extracted by one reviewer, with data extraction headings relating to the principles of screening. A narrative synthesis approach was used to report the information from included studies.Results46 articles were deemed eligible for inclusion. Diabetes-related foot ulcers are an important health condition associated with increased risk of mortality and poorer quality of life. However, there is insufficient evidence on the effectiveness of treatments to prevent disease development. Moreover, while consensus exists on what screening tools should be used to screen for risk factors, there is no agreement on threshold values. Finally, there is no available information on the potential budgetary, organisational or societal implications of a whole-population diabetes-related foot screening programme.ConclusionExisting evidence does not support the introduction of an organised population-wide screening programme in the context of World Health Organisation screening principles. Further research on treatment and management strategies for the at-risk foot and of whole-population screening programmes is required.
Immune predictors of response to immune checkpoint inhibitors in mismatch repair-deficient endometrial cancer
Authors: Grau Bejar Juan Francisco , Yaniz Galende Elisa , Zeng Qinghe , Genestie Catherine , Rouleau Etienne , de Bruyn Marco , Klein Christophe , Le Formal Audrey , Edmond Elodie , Moreau Maëva , Plat Annechien , Gouy Sebastien , Maulard Amandine , Pautier Patricia , Michels Judith , Oaknin Ana , Colomba-Blameble Emeline , Leary Alexandra 
Published: July 2024

BackgroundPatients with mismatch repair-deficient (MMRd) endometrial cancer (EC) can derive great benefit from immune checkpoint inhibitors (ICI). However not all responses and predictors of primary resistance are lacking.MethodsWe compared the immune tumor microenvironment of MMRd EC ICI-responders (Rs) and ICI non-responders (NRs), using spatial multiplexed immune profiling and unsupervised hierarchical clustering analysis.ResultsOverall, NRs exhibited drastically lower CD8+, absent terminally differentiated T cells, lack of mature tertiary lymphoid structures and dendritic cells, as well as loss of human leukocyte antigen class I. However, no single marker could predict R versus NR with confidence. Clustering analysis identified a combination of four immune features that demonstrated that accurately predicted ICI response, with a discriminative power of 92%. Finally, 80% of NRs lacked programmed death-ligand 1, however, 60% exhibited another actionable immune checkpoint (T-cell immunoglobulin and mucin containing protein-3, indoleamine 2,3-dioxygenase 1, or lymphocyte activation gene 3).ConclusionsThese findings underscore the potential of immune tumor microenvironment features for identifying patients with MMRd EC and primary resistance to ICI who should be oriented towards trials testing novel immunotherapeutic combinations.
Identification of a pathogenic mutation inARPP21in patients with amyotrophic lateral sclerosis
Authors: Dols-Icardo Oriol , Carbayo Álvaro , Jericó Ivonne , Blasco-Martínez Olga , Álvarez-Sánchez Esther , López Pérez Maria Angeles , Bernal Sara , Rodríguez-Santiago Benjamín , Cusco Ivon , Turon-Sans Janina , Cabezas-Torres Manuel , Caballero-Ávila Marta , Vesperinas Ana , Llansó Laura , Pagola-Lorz Inmaculada , Torné Laura , Valle-Tamayo Natalia , Muñoz Laia , Rubio-Guerra Sara , Illán-Gala Ignacio , Cortés-Vicente Elena , Gelpi Ellen , Rojas-García Ricard 
Published: July 2024

Background and objectiveBetween 5% and 10% of amyotrophic lateral sclerosis (ALS) cases have a family history of the disease, 30% of which do not have an identifiable underlying genetic cause after a comprehensive study of the known ALS-related genes. Based on a significantly increased incidence of ALS in a small geographical region from Spain, the aim of this work was to identify novel ALS-related genes in ALS cases with negative genetic testing.MethodsWe detected an increased incidence of both sporadic and, especially, familial ALS cases in a small region from Spain compared with available demographic and epidemiological data. We performed whole genome sequencing in a group of 12 patients with ALS (5 of them familial) from this unique area. We expanded the study to include affected family members and additional cases from a wider surrounding region.ResultsWe identified a shared missense mutation (c.1586C>T; p.Pro529Leu) in the cyclic AMP regulated phosphoprotein 21 (ARPP21)gene that encodes an RNA-binding protein, in a total of 10 patients with ALS from 7 unrelated families. No mutations were found in other ALS-causing genes.ConclusionsWhile previous studies have dismissed a causal role ofARPP21in ALS, our results strongly supportARPP21as a novel ALS-causing gene.
Insights into the pathophysiology and response of persistent spinal pain syndrome type 2 to spinal cord stimulation: a human genome-wide association study
Authors: Fabregat-Cid Gustavo , Cedeno David L , De Andrés José , Harutyunyan Anushik , Monsalve-Dolz Vicente , Mínguez-Martí Ana , Escrivá-Matoses Natalia , Asensio-Samper Juan Marcos , Carnaval Thiago , Villoria Jesús , Rodríguez-López Raquel , Vallejo Ricardo 
Published: July 2024

BackgroundSpinal cord stimulation (SCS) provides pain relief for some patients with persistent spinal pain syndrome type 2 (PSPS 2), but the precise mechanisms of action and prognostic factors for a favorable pain response remain obscure. This in vivo human genome-wide association study provides some pathophysiological clues.MethodsWe performed a high-density oligonucleotide microarray analysis of serum obtained from both PSPS 2 cases and pain-free controls who had undergone lower back spinal surgery at the study site. Using multivariate discriminant analysis, we tried to identify different expressions between mRNA transcripts from PSPS 2 patients relative to controls, SCS responders to non-responders, or SCS responders to themselves before starting SCS. Gene ontology enrichment analysis was used to identify the biological processes that best discriminate between the groups of clinical interest.ResultsThirty PSPS 2 patients, of whom 23 responded to SCS, were evaluated together with 15 pain-free controls. We identified 11 significantly downregulated genes in serum of PSPS 2 patients compared with pain-free controls and two significantly downregulated genes once the SCS response became apparent. All were suggestive of enhanced inflammation, tissue repair mechanisms and proliferative responses among the former. We could not identify any gene differentiating patients who responded to SCS from those who did not respond.ConclusionsThis study points out various biological processes that may underlie PSPS 2 pain and SCS therapeutic effects, including the modulation of neuroimmune response, inflammation and restorative processes.
Development, validity, and reliability assessment of the Canadian Food Literacy Measure
Authors: Martin Alicia E. , Wallace Angela , Jacob Raphaëlle , Any Marciane , Laila Amar , Hernandez Kimberley , Perreault Maude , Hutchinson Joy M. , Sadowski Adam , Saher Amina , Dorais Veronique , Kirkpatrick Sharon I. , Haines Jess 
Published: July 2024

Food literacy is a growing area of interest given its potential to support healthy and sustainable diets. Most existing food literacy measures focus on nutrition and food skills but fail to address food systems and socio-environmental aspects of food literacy. Further, measures developed and tested in the Canadian context are lacking. The objective of this project was to develop and test the validity and reliability of a brief self-administered measure, in French and English, designed to assess multiple dimensions of food literacy among adults living in Canada. The 23-item Canadian Food Literacy Measure was developed through an iterative process that included assessment of face and content validity through expert review ( n = 20) and cognitive interviews ( n = 20) and construct validity and reliability, i.e., internal consistency through an online survey ( n = 154). The results indicate that the measure is well understood by both English- and French-speaking adults. The measure’s construct validity is demonstrated by the observed differences in total scores in hypothesized directions by gender ( p = 0.003), age ( p = 0.007), education level ( p = 0.002), health literacy ( p < 0.001) and smoking status ( p = 0.001), and the significant positive correlation ( r = 0.29; p = 0.002) between total scores and fruit and vegetable intake. The measure also has high internal consistency with a Cronbach’s coefficient alpha of 0.80. This measure can be used in surveillance studies to provide insight into the food literacy of adults living in Canada and in epidemiologic research that aims to explore how food literacy is associated with a variety of health outcomes.