bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric Evaluation of the Eating Disorder Examination Adapted for Children
Authors: Hilbert Anja , Buerger Arne , Hartmann Andrea S. , Spenner Kristina , Czaja Julia , Warschburger Petra 
Published: March 2013

AbstractThe Eating Disorder Examination adapted for children (ChEDE) is the child version of the semi‐structured gold standard eating disorder interview for adults. This study was a comprehensive test statistic evaluation of the German ChEDE in a large sample of children and adolescents with anorexia nervosa, binge eating disorder, loss of control eating, overweight and obesity, as well as non‐eating‐disordered and chronically ill control probands (n = 352). Excellent inter‐rater reliability, adequate internal consistency and satisfactory stability of ChEDE indicators were demonstrated. ChEDE indicators discriminated between diverse forms of eating and weight disturbances and normative eating and were significantly correlated with conceptually related measures. Factorial validity was not convincing; a brief eight‐item scale showed the best fit. Item statistics were mostly acceptable. Overall, the ChEDE's German translation reliably and validly assesses psychopathology across the eating and weight disorder spectrum and facilitates international comparison of eating disorder research. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
Complexity reduction for non‐coherent iteratively detected differentially encoded quaternary phase shift keying based on trellis decomposition
Authors: van Houtum W.J. , Willems F.M.J. 
Published: March 2013

AbstractIn this letter, we investigate complexity reduction for non‐coherent iterative detection of differentially encoded quadrature phase shift keying applied to digital audio broadcast receivers. We use 2D blocks in an orthogonal frequency division multiplexing scheme and trellis decomposition to calculate, iteratively, the a posteriori probabilities of the information symbols. Furthermore, the trellis decomposition method allows us to estimate the unknown channel phase efficiently. This phase is related to sub‐trellises of which we can determine the a posteriori probabilities. In our first approach, we investigate a method that is based on finding, at the start of each new iteration, the dominant sub‐trellis first and then do the forward–backward processing for demodulation only in this dominant sub‐trellis. This method reduces the number of multiplications by a factor of 3, the normalizations by a factor 8 and, after five iterations, introducing ≈ 0.05 dB loss in performance on the COST‐207 TU‐6 channel. Our second approach involves choosing the dominant sub‐trellis only once, before starting with the iterations. This results in reducing the number of multiplications and normalizations by a factor of 8 and introduces ≈ 0.5 dB loss in performance. Copyright © 2013 John Wiley & Sons, Ltd.
Dynamic and Asymmetric Dependences Between Chinese Yuan and Other Asia‐Pacific Currencies
Authors: Lien Donald , Wu Chongfeng , Yang Li , Zhou Chunyang 
Published: March 2013

AbstractThis paper examines the dynamic dependence structure between Chinese Yuan and each of five other currencies in the Asia‐Pacific region on non‐deliverable forward contracts over the period of July 4, 2006 throughout August 31, 2011. Using the date that Lehman Brothers filed for bankruptcy as the starting date of financial crisis, we find that, before the crisis, the dependences between Chinese Yuan and four out of five other Asian pacific currencies under consideration are much stronger when Chinese Yuan against the U.S. dollar depreciates than when it appreciates. During the crisis, the asymmetric tail dependences still prevail with the magnitude of both upper and lower tail dependences as well as correlation increasing substantially. The dynamic and asymmetric dependence structure documented in this study has important implications for the investors in the region. © 2013 Wiley Periodicals, Inc. Jrl Fut Mark
Pre‐modern Arctic Ocean circulation from surface sediment neodymium isotopes
Authors: Haley Brian A. , Polyak Leonid 
Published: March 2013

AbstractWe present a survey of Nd isotopes measured from authigenic phases on surface sediments from the Arctic Ocean seafloor. Comparison with published dissolved water column Nd isotope distributions suggests that εNd from sediment leachates accurately represents bottom water circulation of the Arctic Ocean, with Atlantic (~−11 εNd) and Pacific (~−5 εNd) water end‐members clearly distinguishable. Nd isotopic data from the Chukchi margin show several apparent deviations from the expected pattern, which imply that this margin has been a region of sustained shelf‐to‐basin sediment redistribution and/or a region where deep water cascades downslope, such as through brine rejection during ice formation. These data also provide insights into a pre‐anthropocene “baseline” (several thousand years) for investigating Arctic Ocean circulation in a changing climate; the data presented here are indicative that these changes may be impacting the deep as well as surface ocean.
Intraoperative high‐dose‐rate radiotherapy in the management of locoregionally recurrent head and neck cancer
Authors: Scala L. Matthew , Hu Kenneth , Urken Mark L. , Jacobson Adam S. , Persky Mark S. , Tran Theresa N. , Smith Mark L. , Schantz Stimson , Harrison Louis B. 
Published: March 2013

AbstractBackgroundThe purpose of this article was to present the Beth Israel Medical Center experience using high‐dose‐rate intraoperative radiotherapy (HDR‐IORT) in the management of recurrent head and neck cancer.MethodsWe conducted a retrospective review of all patients with locally or regionally recurrent head and neck cancer who underwent HDR‐IORT at our institution between 2001 and 2010.ResultsSeventy‐six patients were identified who underwent treatment to a total of 87 sites after gross‐total resection. The 2‐year estimate of in‐field tumor control was found to be 62%. Median overall survival was 19 months with 42% of the patients surviving at least 2 years. Significantly longer survival was found for patients achieving in‐field control versus infield progression (33 months vs 17 months, respectively; p = .01).ConclusionHDR‐IORT is well tolerated and associated with encouraging in‐field disease control. In‐field control is associated with improved survival. Further study is warranted to more fully investigate HDR‐IORT in the salvage setting. © 2013 Wiley Periodicals, Inc. Head Neck, 2013
C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice
Authors: Chu Po-sung , Nakamoto Nobuhiro , Ebinuma Hirotoshi , Usui Shingo , Saeki Keita , Matsumoto Atsuhiro , Mikami Yohei , Sugiyama Kazuo , Tomita Kengo , Kanai Takanori , Saito Hidetsugu , Hibi Toshifumi 
Published: March 2013

Abstract

Chemokine receptors mediate migration of immune cells into the liver, thereby promoting liver inflammation. C-C motif chemokine receptor (CCR) 9+ macrophages are crucial in the pathogenesis of acute liver inflammation, but the role and underlying mechanisms of this macrophage subset in chronic liver injury and subsequent liver fibrosis are not fully understood. We confirmed that tumor necrosis factor alpha (TNF-α)-producing CCR9+ macrophages accumulated during the initiation of carbon tetrachloride (CCl4)-induced liver injury, and CCR9 deficiency attenuated the degree of liver damage. Accumulation of CCR9+ macrophages persisted prominently during the process of liver fibrosis induced by repetitive CCl4 or thioacetamide (TAA)/leptin administration. Increased CCR9 expression was also found on activated hepatic stellate cells (HSCs). Importantly, experimental liver fibrosis was significantly ameliorated in CCR9
−/− mice compared with wild-type (WT) mice, assessed by α-smooth muscle actin (α-SMA) immunostain, Sirius red staining, and messenger RNA (mRNA) expression levels of α-SMA, collagen 1α1, transforming growth factor (TGF)-β1, and tissue inhibitor of metalloproteinase (TIMP)-1. Accumulated CD11b+ macrophages in CCl4-treated WT mice showed marked increases in TNF, NO synthase-2, and TGF-β1 mRNA expression compared with CCR9
−/− mice, implying proinflammatory and profibrogenic properties. Hepatic CD11b+ macrophages from CCl4-treated WT mice (i.e., CCR9+ macrophages), but not CD8+ T lymphocytes or non-CD11b+ cells, significantly activated HSCs in vitro compared with those from CCR9
−/− mice. TNF-α or TGF-β1 antagonism attenuated CCR9+ macrophage-induced HSC activation. Furthermore, C-C motif chemokine ligand (CCL) 25 mediated migration and, to a lesser extent, activation of HSCs in vitro. Conclusion: Accumulated CD11b+ macrophages are critical for activating HSCs through the CCR9/CCL25 axis and therefore promote liver fibrosis. CCR9 antagonism might be a novel therapeutic target for liver fibrosis. (HEPATOLOGY 2013;)
Sexual experience restores age‐related decline in adult neurogenesis and hippocampal function
Authors: Glasper Erica R. , Gould Elizabeth 
Published: March 2013

AbstractAging is associated with compromised hippocampal function and reduced adult neurogenesis in the dentate gyrus. As new neurons have been linked to hippocampal functions, such as cognition, age‐related decline in new neuron formation may contribute to impaired hippocampal function. We investigated whether a rewarding experience known to stimulate neurogenesis in young adult rats, namely sexual experience, would restore new neuron production and hippocampal function in middle‐aged rats. Sexual experience enhanced the number of newly generated neurons in the dentate gyrus with both single and repeated exposures in middle‐aged rats. Following continuous long‐term exposure to sexual experience, cognitive function was improved. However, when a prolonged withdrawal period was introduced between the final mating experience and behavioral testing, the improvements in cognitive function were lost despite the presence of more new neurons. Taken together, these results suggest that repeated sexual experience can stimulate adult neurogenesis and restore cognitive function in the middle‐aged rat as long as the experience persists throughout the testing period. The extent to which changes in adult neurogenesis underlie those in cognition remain unknown. © 2013 Wiley Periodicals, Inc.
Differential role of the dorsal hippocampus, ventro‐intermediate hippocampus, and medial prefrontal cortex in updating the value of a spatial goal
Authors: Blanquat Paul De Saint , Hok Vincent , Save Etienne , Poucet Bruno , Chaillan Franck A. 
Published: March 2013

AbstractEncoding of a goal with a specific value while performing a place navigation task involves the medial prefrontal cortex (mPFC) and the dorsal hippocampus (dHPC), and depends on the coordination between mPFC and the ventro‐intermediate hippocampus (vHPC).The present work investigates the contribution of mPFC, dHPC, and vHPC when the rat has to update the value of a goal. Rats were trained to navigate to an uncued goal in order to release a food pellet in a continuous place navigation task. When they had reached criterion performance level in the task, they were subjected to a single “flash session” in which they were exposed to an aversive strobe light during goal visits instead of receiving a food reward. Just before the flash session, the GABAA agonist muscimol was injected to temporarily inactivate mPFC, dHPC, or vHPC. The ability to recall the changed value of the goal was tested on the next day. We first demonstrate the aversive effect of the strobe light by showing that rats learn to avoid the goal much more rapidly in the flash session than during a simple extinction session in which goal visits are not rewarded. Furthermore, while dHPC inactivation had no effect on learning and recalling the new goal value, vHPC muscimol injections considerably delayed goal value updating during the flash session, which resulted in a slight deficit during recall. In contrast, mPFC muscimol injections induced faster goal value updating but the rats were markedly impaired on recalling the new goal value on the next day. These results suggest that, contrary to mPFC and dHPC, vHPC is required for updating the value of a goal. In contrast, mPFC is necessary for long‐term retention of this updating. © 2013 Wiley Periodicals, Inc.
Knock down of caveolin‐1 affects morphological and functional hallmarks of human endothelial cells
Authors: Madaro Luca , Antonangeli Fabrizio , Favia Annarita , Esposito Bianca , Biamonte Filippo , Bouché Marina , Ziparo Elio , Sica Gigliola , Filippini Antonio , D'Alessio Alessio 
Published: March 2013

AbstractCaveolin‐1 (CAV1) is the principal structural component of caveolae which functions as scaffolding protein for the integration of a variety of signaling pathways. In this study, we investigated the involvement of CAV1 in endothelial cell (EC) functions and show that siRNA‐induced CAV1 silencing in the human EC line EA.hy926 induces distinctive morphological changes, such as a marked increase in cell size and formation of stress fibers. Design‐based stereology was employed in this work to make unbiased quantification of morphometric properties such as volume, length, and surface of CAV1 silenced versus control cells. In addition, we showed that downregulation of CAV1 affects cell cycle progression at G1/S phase transition most likely by perturbation of AKT signaling. With the aim to assess the contribution of CAV1 to typical biological processes of EC, we report here that CAV1 targeting affects cell migration and matrix metalloproteinases (MMPs) activity, and reduces angiogenesis in response to VEGF, in vitro. Taken together our data suggest that the proper expression of CAV1 is important not only for maintaining the appropriate morphology and size of ECs but it might represent a prospective molecular target for studying key biological mechanisms such as senescence and tumorigenesis. J. Cell. Biochem. 114: 1843–1851, 2013. © 2013 Wiley Periodicals, Inc.
Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk‐1‐dependent Mcl‐1 transcription and inducing Akt/GSK3β‐dependent protein degradation
Authors: Sun Nian‐Kang , Huang Shang‐Lang , Chang Ting‐Chang , Chao Chuck C.‐K. 
Published: March 2013

AbstractEndometrial carcinoma (EC) is one of the main gynecologic malignancies affecting women, but effective treatments are currently lacking. In the present study, we investigated the effect of sorafenib, a general kinase inhibitor, on several EC cell lines (HEC1A, HEC1B, and RL95‐2). Sorafenib induced cell death in EC cells with the following order of sensitivity: HEC1A > HEC1B > RL95‐2. Sorafenib suppressed several anti‐apoptotic proteins in HEC1A cells, including myeloid cell leukemia 1 (Mcl‐1). Ectopic overexpression of Mcl‐1 prevented the cell killing effect of sorafenib. Sorafenib suppressed Mcl‐1 at the gene transactivation level by inactivating the ERK/Elk‐1 pathway. Accordingly, the inhibitory effect of sorafenib on Mcl‐1 expression decreased following knockdown of Elk‐1 using short‐hairpin RNA (shRNA). Elk‐1 overexpression rescued both the inhibitory effect of sorafenib on Mcl‐1 expression and the cell killing effect of sorafenib. Furthermore, sorafenib reduced the stability of the Mcl‐1 protein by enhancing its ubiquitination and degradation by the proteasome via the AKT/GSK3β and the ERK pathways. Similar results were detected in other EC cell lines. These results indicate that sorafenib induces apoptosis in EC cells by down‐regulating the anti‐apoptotic protein Mcl‐1 via transcriptional inhibition and protein degradation. Our results thus support the notion that sorafenib may be used in endometrial cancer therapy. J. Cell. Biochem. 114: 1819–1831, 2013. © 2013 Wiley Periodicals, Inc.
Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels
Authors: Parks Scott K. , Mazure Nathalie M. , Counillon Laurent , Pouysségur Jacques 
Published: March 2013

AbstractThe efficacy of targeting pH disruption to induce cell death in the acidic and hypoxic tumor microenvironment continues to be assessed. Here we analyzed the impact of varying levels of hypoxia in acidic conditions on fibroblast and tumor cell survival. Across all cell lines tested, hypoxia (1% O2) provided protection against acidosis induced cell death compared to normoxia. Meanwhile severe hypoxia (0.1% O2) removed this protection and in some cases exacerbated acidosis‐induced cell death. Differential survival between cell types during external acidosis correlated with their respective intracellular pH regulating capabilities. Cellular ATP measurements were conducted to determine their contribution to cell survival under these combined stresses. In general, hypoxia (1% O2) maintained elevated ATP levels in acidic conditions while severe hypoxia did not. To further explore this interaction we combined acidosis with ATP depletion using 2‐deoxyglucose and observed an enhanced rate of cell mortality. Striking results were also observed with hypoxia providing protection against cell death in spite of a severe metabolic stress induced by a combination of acidosis and oligomycin. Finally, we demonstrated that both HIF1α and HIF2α expression were drastically reduced in hypoxic and acidic conditions indicating a sensitivity of this protein to cellular pH conditions. This knockdown of HIF expression by acidosis has implications for the development of therapies targeting the disruption of cellular pH regulation. Our results reinforce the proof of concept that acidosis and metabolic disruption affecting ATP levels could be exploited as a tumor cell killing strategy. J. Cell. Physiol. 228: 1854–1862, 2013. © 2013 Wiley Periodicals, Inc.
mTOR signaling for biological control and cancer
Authors: Alayev Anya , Holz Marina K. 
Published: March 2013

AbstractMammalian target of rapamycin (mTOR) is a major intersection that connects signals from the extracellular milieu to corresponding changes in intracellular processes. When abnormally regulated, the mTOR signaling pathway is implicated in a wide spectrum of cancers, neurological diseases, and proliferative disorders. Therefore, pharmacological agents that restore the regulatory balance of the mTOR pathway could be beneficial for a great number of diseases. This review summarizes current understanding of mTOR signaling and some unanswered questions in the field. We describe the composition of the mTOR complexes, upstream signals that activate mTOR, and physiological processes that mTOR regulates. We also discuss the role of mTOR and its downstream effectors in cancer, obesity and diabetes, and autism. J. Cell. Physiol. 228: 1658–1664, 2013. © 2013 Wiley Periodicals, Inc.
Intracranial hemangiopericytoma: MR imaging findings and diagnostic usefulness of minimum ADC values
Authors: Liu Gang , Chen Zhi‐Ye , Ma Lin , Lou Xin , Li Shi‐Jun , Wang Yu‐Lin 
Published: March 2013

PurposeTo describe the clinical and magnetic resonance (MR) imaging features of primary intracranial hemangiopericytoma (HPC), and to assess the usefulness of minimum apparent diffusion coefficient (MinADC) value of HPC in the differential diagnosis from meningioma.Materials and MethodsFrom 2004 to 2010, fifteen patients with primary intracranial HPC were included. The clinical data, conventional MR findings (n = 15), and diffusion weighted image (DWI) features (n = 10) were retrospectively analyzed. MinADC value of the HPCs (n = 10) was measured on ADC map and was compared with that of meningiomas (n = 37).ResultsIn 15 cases of HPC, isointense signal was detected on both T1‐weighted images (T1WI) and T2‐weighted images (T2WI) in 11 cases, and heterogeneous signal was demonstrated in 4 cases. Isointensity (n = 9) and iso‐ and slight hyperintensity (n = 1) were shown on DWI. The mean MinADC value of HPC [(1.116 ± 0.127) × 10−3 mm2/s] was significantly higher than that of meningioma [(0.875 ± 0.104) × 10−3 mm2/s] (P < 0.01). For the differentiation between HPC and meningioma, the critical cutoff MinADC value was 0.991 × 10−3 mm2/s, which provided the best combination of sensitivity (88.9%) and specificity (82.4%).ConclusionMinADC value may be an useful tool for the differentiation between HPC and meningioma. J. Magn. Reson. Imaging 2013;38:1146–1151. © 2013 Wiley Periodicals, Inc.
Shaped beam synthesis of phased arrays using the cross entropy method
Authors: Weatherspoon Mark H. , Connor Jeffrey D. , Foo Simon Y. 
Published: March 2013

AbstractThis paper describes the shaped‐beam synthesis of phased arrays using the cross entropy (CE) method. The CE method is a general stochastic optimization technique based on minimizing the CE (or Kullback–Leibler divergence) between sets of probability distributions to solve complex multi‐extremal, multi‐objective optimization problems. In this work, the CE method will be utilized to choose the complex weights of array element excitations to control the shape of far‐field radiation pattern side lobe power, main lobe beamwidth, and introduce side lobe notches using amplitude‐only and complex weight synthesis. Compared with similar stochastic techniques previously used to solve this problem, such as the genetic algorithm and particle swarm optimization, the CE method is a competitive alternative, possessing attractive convergence properties. Copyright © 2013 John Wiley & Sons, Ltd.