bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a topically applied 2% delta-9-tetrahydrocannabinol ophthalmic solution on intraocular pressure and aqueous humor flow rate in clinically normal dogs
Authors: Fischer Kristin M. , Ward Daniel A. , Hendrix Diane V. H. 
Published: January 2013

Abstract
Objective—To determine the effects of topically applied 2% delta-9-tetrahydrocannabinol (THC) ophthalmic solution on aqueous humor flow rate (AHFR) and intraocular pressure (IOP) in clinically normal dogs.
Animals—21 clinically normal dogs.
Procedures—A randomized longitudinal crossover design was used. Following acquisition of baseline IOP (morning and evening) and AHFR (afternoon only) data, dogs were randomly assigned to 2 treatment groups and received 1 drop of either 2% THC solution or a control treatment (olive oil vehicle) to 1 randomly selected eye every 12 hours for 9 doses. The IOPs and AHFRs were reassessed after the final treatment. Following a washout period of ≥ 7 days, dogs were administered the alternate treatment in the same eye, and measurements were repeated.
Results—Mean ± SD IOPs in the morning were 15.86 ± 2.48 mm Hg at baseline, 12.54 ± 3.18 mm Hg after THC treatment, and 13.88 ± 3.28 mm Hg after control treatment. Mean ± SD IOPs in the evening were 13.69 ± 3.36 mm Hg at baseline, 11.69 ± 3.94 mm Hg after THC treatment, and 12.13 ± 2.99 mm Hg after control treatment. Mean IOPs were significantly decreased from baseline after administration of THC solution but not the control treatment. Changes in IOP varied substantially among individual dogs. Mean ± SD AHFRs were not significantly different from baseline for either treatment.
Conclusions and Clinical Relevance—Topical application of 2% THC ophthalmic solution resulted in moderate reduction of mean IOP in clinically normal dogs. Further research is needed to determine efficacy in dogs with glaucoma.
Effects of topical ocular administration of high doses of human recombinant interferon alpha-2b and feline recombinant interferon omega on naturally occurring viral keratoconjunctivitis in cats
Authors: Slack Jessica M. , Stiles Jean , Leutenegger Christian M. , Moore George E. , Pogranichniy Roman M. 
Published: January 2013

Abstract
Objective—To determine whether 14-day topical ocular administration of high doses of feline recombinant interferon omega (FelFN) or human recombinant interferon alpha-2b (HulFN) solution improves clinical disease and decreases virus shedding in cats with naturally acquired viral keratoconjunctivitis.
Animals—36 cats with upper respiratory tract disease and ocular involvement.
Procedures—Cats received 1 drop of FelFN solution (1 × 106 U/mL), HulFN solution (1 × 106 U/mL), or saline (0.9% NaCl) solution (12 cats/group) in each eye twice daily for 14 days (beginning day 1). Oropharyngeal and conjunctival swab samples were collected from each cat before (day 0) and on day 14 of treatment for virus isolation (VI) and real-time quantitative PCR (RT-qPCR) testing to detect feline herpesvirus-1 and feline calicivirus. Subjective clinical scores were recorded on days 0, 3, 7, 10, and 14.
Results—The number of cats for which feline herpesvirus-1 was detected via VI or RT-qPCR assay was generally (albeit not always significantly) lower on day 14, compared with day 0 findings; however, findings on days 0 or 14 did not differ among groups. The number of cats for which feline calicivirus was detected via VI or RT-qPCR assay did not differ significantly between days 0 and 14 for any group. Clinical scores significantly decreased over the 14-day period but did not differ among groups.
Conclusions and Clinical Relevance—In cats with naturally occurring viral keratoconjunctivitis, bilateral ocular administration of high doses of FelFN or HulFN twice daily for 14 days did not improve clinical disease or virus shedding, compared with treatment with saline solution.
Evaluation of mass spectrometry of urinary proteins and peptides as biomarkers for cats at risk of developing azotemia
Authors: Jepson Rosanne E. , Coulton Gary R. , Cowan Matthew L. , Markwell Peter , Syme Harriet M. , Elliott Jonathan 
Published: January 2013

Abstract
Objective—To evaluate proteomic delineation of feline urine by mass spectrometry as a method for identifying biomarkers in cats at risk of developing azotemia.
Samples—Urine samples from geriatric cats (> 9 years old) with chronic kidney disease and nonazotemic cats that either remained nonazotemic (n = 10) or developed azotemia (10) within 1 year.
Procedures—Optimization studies with pooled urine were performed to facilitate the use of surface enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF-MS) for analysis of the urinary proteome of cats. Urine samples from nonazotemic cats at entry to the study were analyzed via SELDI-TOF-MS with weak cation exchange and strong anion exchange arrays. Spectral data were compared to identify biomarkers for development of azotemia.
Results—Low protein concentration in feline urine precluded direct application to array surfaces, and a buffer exchange and concentration step was required prior to SELDI-TOF-MS analysis. Three preparation conditions by use of weak cation and strong anion exchange arrays were selected on the basis of optimization studies for detection of biomarkers. Eight potential biomarkers with an m/z of 2,822, 9,886, 10,033, 10,151, 10,234, 11,653, 4,421, and 9,505 were delineated.
Conclusions and Clinical Relevance—SELDI-TOF-MS can be used to detect urinary low-molecular weight peptides and proteins that may represent biomarkers for early detection of renal damage. Further study is required to purify and identify potential biomarkers before their use in a clinical setting.
Outcome evaluation of a thoracoscopic pericardial window procedure or subtotal pericardectomy via thoracotomy for the treatment of pericardial effusion in dogs
Authors: Case J. Brad , Maxwell Mac , Aman Anna , Monnet Eric L. 
Published: January 2013

Abstract
Objective—To evaluate the disease-free interval (DFI) and median survival time (MST) in dogs with idiopathic and neoplastic pericardial effusion surgically treated by a thoracoscopic pericardial window procedure or subtotal pericardectomy via thoracotomy and to compare DFI and MST in dogs with and without a mass on preoperative echocardiography that underwent either surgical technique.
Design—Retrospective cohort study.
Animals—58 dogs with pericardial effusion.
Procedures—Medical records between 1985 and 2010 were evaluated. Dogs were included in the study if they had confirmed pericardial effusion and underwent a thoracoscopic pericardial window procedure or subtotal pericardectomy via thoracotomy.
Results—Clinical signs of dogs at initial evaluation were similar, with the exception of lethargy, between dogs treated by subtotal pericardectomy via thoracotomy or the pericardial window procedure. Dogs with idiopathic pericardial effusion that underwent the thoracoscopic pericardial window procedure had significantly shorter DFI and MST than did those treated by subtotal pericardectomy via thoracotomy. For neoplastic pericardial effusion, DFI and MST were not significantly different between dogs treated with either surgical technique.
Conclusions and Clinical Relevance—Dogs with idiopathic pericardial effusion treated with a subtotal pericardectomy via thoracotomy had a significantly longer DFI and MST, compared with dogs treated by the thoracoscopic pericardial window procedure. This difference in outcome may be related to inaccuracy of the initial diagnosis or ineffectiveness of the pericardial window to palliate the signs of idiopathic pericardial effusion long term.
Effects of postanesthetic sedation with romifidine or xylazine on quality of recovery from isoflurane anesthesia in horses
Authors: Woodhouse Kerry J. , Brosnan Robert J. , Nguyen Kyvan Q. , Moniz Gale W. , Galuppo Larry D. 
Published: January 2013

Abstract
Objective—To test the hypothesis that postanesthetic sedation with romifidine would dose-dependently improve recovery quality of recovery from isoflurane anesthesia in horses more than postanesthetic sedation with xylazine.
Design—Prospective, randomized, blinded clinical trial.
Animals—101 healthy adult horses examined at the University of California-Davis Veterinary Medical Teaching Hospital from 2007 to 2009.
Procedures—Horses were sedated with xylazine, and anesthesia was induced with guaifenesin, diazepam, and ketamine via a standardized drug protocol. Anesthesia for surgical or diagnostic procedures was maintained with isoflurane in oxygen for 1 to 4 hours. At the end of anesthesia, horses were moved to a padded stall for recovery. Once the breathing circuit was disconnected and the patient was spontaneously breathing, either xylazine (100 or 200 μg/kg [45 or 91 μg/lb]) or romifidine (10 or 20 μg/kg [4.5 or 9.1 μg/lb]) was administered IV. Objective patient, surgical, and anesthesia data were recorded. Subjective visual analog scale (VAS) scores of recovery quality were assigned by a single individual who was unaware of the treatment received. A stepwise linear regression model was used to correlate patient and procedure factors with the VAS score.
Results—Painful procedures, longer anesthesia times, and the Arabian horse breed were associated with poorer VAS scores. Adjustment for these factors revealed an improved VAS recovery score associated with the use of a romifidine dose of 20 μg/kg.
Conclusions and Clinical Relevance—In healthy adult horses anesthetized with isoflurane for > 1 hour, the results of this study supported the use of 20 μg of romifidine/kg, IV, rather than lower romifidine doses or xylazine, for postanesthetic sedation to improve recovery quality.
Treatment of effluents from a membrane bioreactor by nanofiltration using tubular membranes
Authors: Karakulski Krzysztof , Gryta Marek , Bastrzyk Justyna 
Published: January 2013

AbstractProduction of bioproducts is associated with the generation of considerable amounts of effluents from the bioreactors used. Application of the nanofiltration process was proposed for the treatment of these effluents in order to separate both inorganic and organic solutes. Composition of the fermentation broth precludes the utilization of traditional spiral-wound modules (high turbidity) for the solutes separation in the NF process. The tubular module with AFC30 membranes applied in this work enables such a possibility. Transport and separation characteristics of the NF membrane were determined for the reference solutions containing components present in the effluents generated during the fermentation of glycerol with the use of bacteria.
Kinetics of thermal decomposition of aseptic packages
Authors: Haydary Juma , Susa Dalibor 
Published: January 2013

AbstractKinetics of thermal decomposition of aseptic packages (e.g. Tetrapak cartons) and pyrolysis of this waste in a laboratory flow reactor was studied. Three different models for the calculation of the reaction rate and the determination of apparent kinetic parameters of thermal decomposition were used. The first method assumes a two stage thermal decomposition and the kinetic parameters were determined by fitting a derivative thermogravimetric (DTG) curve to experimentally determined thermogravimetric data of whole aseptic cartons. The second method uses kinetic parameters determined by fitting DTG curves to thermogravimetric data of individual components of aseptic packages. The last method was a multi-curve isoconversion method assuming a change of kinetic parameters with the increasing conversion. All types of the determined kinetic parameters were used in a mathematical model for thermal decomposition of mini briquettes made from aseptic packages at the temperature of 650°C. The model calculated also the heat conduction in the particles and it was verified by an independent set of experiments conducted in a laboratory screw type flow reactor.
A new, fully validated and interpreted quantitative structure-activity relationship model of p-aminosalicylic acid derivatives as neuraminidase inhibitors
Authors: Hartmman Ana , Jornada Daniela , Melo Eduardo 
Published: January 2013

AbstractA multivariate QSAR study with a set of 34 p-aminosalicylic acid derivatives, described as neuraminidase inhibitors of the H1N1 viruses, is presented in this work. The variable selection was performed with the Ordered Predictors Selection (OPS) algorithm and the model was built with the Partial Least Squares (PLS) regression method. Leave-N-out cross-validation and y-randomization tests showed that the model was robust and free from chance correlation. The external predictive ability was superior to the 3D-QSAR model previously published. Moreover, it was possible to perform a mechanistic interpretation, where the descriptors referred directly to the mechanism of interaction with the neuraminidase.
Effect of ionic liquid on polyaniline chemically synthesised under falling-pH conditions
Authors: Krishna Anurag , Laslau Cosmin , Waterhouse Geoffrey , Zujovic Zoran , Travas-Sejdic Jadranka 
Published: January 2013

AbstractThis study investigates the effect of the ionic liquid 1-butyl-3-methyl imidazolium chloride ([bmim]Cl) on the morphological, structural, and electronic properties of polyaniline (PANI) products synthesised by the falling-pH method. Products were characterised by SEM, FT-IR, UVVIS, N2-physisorption, and conductivity measurements. The [bmim]Cl addition strongly influenced the PANI morphology, specific surface area, porosity, and conductivity. Depending on the [bmim]Cl: ANI ratio and the synthesis pH, a wide range of PANI nanostructures could be prepared, with rod-like, and fibre-like elongated structures being the dominant morphology under most experimental conditions. Samples prepared in the presence of [bmim]Cl exhibit specific areas of ca 22–35 m2 g−1. The conductivity of the final products depends on the [bmim]Cl: ANI ratio. Temperature dependence of conductivity in the temperature range from 77 K to 300 K was also studied.
Normal modes of a coupled ice-shelf/sub-ice-shelf cavity system
Authors: Sergienko Olga V. 
Published: January 2013

AbstractIce shelves and ice tongues are dynamically coupled to their cavities. Here we compute normal modes (eigenfrequencies and eigenfunctions) of this coupled system using a thin-plate approximation for the ice shelf and potential water flow in the ice-shelf cavity. Our results show that normal modes depend not only on the ice-shelf parameters (length, thickness, Young’s modulus, etc.) but also on the cavity depth. The dominant eigenmodes are higher for ice shelves floating over deeper cavities; they are also higher for shorter ice shelves and ice tongues (<50 km long). The higheigenfrequency eigenmodes are primarily controlled by the ice flexure and have similar periods to sea swell. These results suggest that both long ocean waves with periods of 100–400 s and shorter sea swell with periods of 10–20 s can have strong impacts on relatively short ice shelves and ice tongues by exciting oscillations with their eigenfrequencies, which can lead to iceberg calving and, in some circumstances, ice-shelf disintegration.
Modes of failure in tubular plant organs
Authors: Spatz Hanns–Christof , Niklas Karl J. 
Published: January 2013

• Premise of study: Hollow tubular organs can bend and deform in one of two ways, i.e., either globally in long‐wave deformation or locally in short‐wave deformation (i.e., Brazier buckling). Either of these two types of behavior can cause death. Understanding the biophysical advantages and disadvantages of possessing hollow plant organs is important therefore to understanding plant ecology and avoiding damage to private or public property.• Methods: We present computer simulations that successfully predict when a hollow organ experiences different modes of failure as a function of organ length and wall thickness as well as material properties.• Key results and conclusions: When self‐supporting, tubular plant organs are amenable to long‐wave buckling and Brazier (short‐wave) buckling under gravitational or wind‐induced forces. For very slender tubes constructed of isotropic tissues, Brazier buckling depends on the outer wall radius and wall thickness (specifically Rt2). Particularly for organs constructed of anisotropic tissues, Brazier buckling becomes a complex phenomenon that depends on a number of geometric parameters (including length of the hollow section) as well as the material properties of tissues. This complexity precludes a definitive (canonical) limit to the relationship between wall thickness and outer radius and the safety limits for Brazier buckling.
Relancer la dynamique de connaissances dans des contextes relationnels dégradés
Authors: Simoni Gilda 
Published: January 2013

Résumé L’enchaînement de plus en plus rapide des projets et la généralisation d’outils d’évaluation individualisants peuvent dégrader les « interactions relations connaissances » au sein des équipes de R&D. L’objectif de cet article est d’analyser les modes d’action des managers pour améliorer ces interactions. A partir de l’étude de quatre équipes de R&D d’une multinationale haute technologie, nous montrons que, si la relance de la dynamique des connaissances peut se réaliser au moyen de modes d’action diversifiés, son effectivité dépend de la prise en compte de l’état dégradé des relations par les managers. Cette analyse contribue à préciser comment intégrer la dimension relationnelle dans les projets de management des connaissances.
Dualités de forme de pratique féminine de ski et de consommation de matériel de glisse
Authors: Vignal Bénédicte , Champely Stéphane , Chantelat Pascal 
Published: January 2013

Résumé L’objectif de cet article est d’améliorer la connaissance de la pratiquante de ski alpin et de ses logiques de consommation de matériel de glisse. Quelques questions simples peuvent schématiser notre réflexion : Qui est la pratiquante de ski ? Que fait-elle sur les planches ? Comment achète-t-elle son matériel de glisse ? Sa consommation est-elle influencée par sa position sociale et sa modalité de pratique ? Ces questions seront étudiées dans le cadre des théories sociologiques des pratiques sportives et de la consommation. La méthodologie repose sur un sondage (n=318) par questionnaire en station de sports d’hiver. On repère deux dimensions-profils de pratiquantes : l’une majoritaire, que nous avons qualifiée de « jouisseuse », à la recherche de convivialité, de détente et de contemplation, l’autre minoritaire, que nous avons appelée « performeuse » et dont la pratique répond à une dépense d’énergie, une prise de risque et un souci technique. Paradoxalement, c’est ce second profil que visent prioritairement les marques dans leur communication. En ce qui concerne le matériel de glisse, la segmentation du marché entre location (70%) et achat (30%) conduit à des critères de choix communs d’abord centrés sur une technologie adaptée aux femmes, facile à skier, légère, mais qui se différencient en demandant un rapport qualité/prix avantageux chez les acheteuses alors que les loueuses avouent aussi un « choix par défaut ». Ce dernier renvoie au rôle essentiel du conseilleur loueur ou vendeur et aux répercussions managériales que cela implique. Les critères esthétiques souvent évoqués pour la consommation féminine ne sont pas mis en avant ici. La segmentation acheteuse versus loueuse est opérée par la technique statistique innovante de la régression logistique avec lasso qui relève d’abord des éléments spatiaux et temporels de la sociodémographie et des formes de pratiques et, secondairement, motivationnels. Enfin, les deux profils de pratiquantes seront reliés à leurs formes de pratique et modes de consommation.
Le risque de l'implicite sur l'acceptation d'une innovation et sur l'attitude envers la marque : une recherche exploratoire
Authors: Hetet Blandine , Moutot Jean-Michel 
Published: January 2013

Résumé Cette recherche exploratoire analyse le risque que représente l’implicite sur l’acceptation d’une innovation et l’attitude des consommateurs envers la marque. L’impact des attitudes implicites sur la diffusion et l’acceptation d’une innovation sont examinés dans le contexte d’une recherche étudiant les attitudes de participants à des focus group vis-à-vis d’une innovation technologique. Une analyse a permis de mettre en évidence les nouvelles implications des attitudes implicites envers deux champs de recherche très présents dans le marketing : l’innovation et la marque. Une analyse approfondie du discours des participants et la mise en place d’une méthode telle que le TAI est envisagée pour étayer ces premiers résultats exploratoires.
Façonner la Cour suprême des années 2020 : les nominations Roberts et Alito
Authors: Michelot Vincent 
Published: January 2013

Résumé Les nominations récentes de John Roberts à la présidence de la Cour puis de Samuel Alito furent exceptionnelles à trois titres au moins : l’absence de nominations à la Cour suprême pendant une période anormalement longue de onze ans et les bouleversements dans le calendrier, la personnalité et le rôle dans l’institution des juges appelés à être remplacés, enfin le contexte politique de tension autour de la guerre en Irak et de déclin concomitant de la popularité du président dans lequel ces changements de personnel à la Cour interviennent.
UE-Otan-États-Unis : vers un « ménage à trois » vertueux
Authors: Michel Leo G. 
Published: January 2013

Résumé Le temps et l’expérience ont permis de mieux juger les forces et les faiblesses de l’ Otan , de l’UE, des opérations bilatérales et autres « coalitions volontaires ». Étant donné la complexité des questions de sécurité internationale après le 11/9, n’est-il pas temps de réfléchir de façon à la fois plus ambitieuse et plus pratique à un ménage à trois vertueux entre l’UE, les États-Unis et l’ Otan ? La France soutiendra-t-elle ou affaiblira-t-elle cet effort ?
Les conversions de l'hystérie
Authors: Usobiaga Isabel 
Published: January 2013

Résumé Je propose que les structures mentales peuvent être modifiables à l’âge adulte à travers le parcours analytique. Je parle de l’hystérie. Je fais un court parcours par l’œuvre de Freud, et l’hystérie aujourd’hui pour évoquer, à travers mon expérience clinique, plusieurs cas dans lesquels je pense que ce fonctionnement a été possible, fonctionnement les menant vers une « certaine hystérisation ». Je trouve que l’humour est le point commun de mes interventions. Je parle du contre-transfert de base et je passe à l’analyste aujourd’hui face aux nouvelles pathologies, entre autres les « conversions de l’hystérie ».
L'identification primaire et la bisexualité psychique
Authors: Abrevaya Elda 
Published: January 2013

Résumé Freud définit les identifications primaires comme constituant la base de l’édifice du complexe d’Œdipe et de la bisexualité psychique. En premier abord, il s’agit de l’identification au « père de la préhistoire individuelle ». Cependant, l’identification de l’enfant par le père et l’assignation d’un genre – fille ou garçon – à celui-ci, semble un moment aussi fondamental que l’identification au père. Ces deux mouvements identificatoires passent par le désir de la mère pour le père.
Du côté du père amant. Censure ou refoulement ?
Authors: Schaeffer Jacqueline 
Published: January 2013

Résumé La « censure de l’amante » ne paraît pas transposable, symétriquement, du côté d’une « censure de l’amant ». Le contre-investissement de la confusion des émois érotiques de la mère, par une alternance nuit/jour, est transmis à l’enfant dans une relation de corps et de chair avec un bébé. La relation du père amant n’a lieu qu’avec le corps de l’enfant, et c’est sur l’objet qu’il doit opérer un refoulement entre le corps de mère et le corps de femme. La différence des sexes influence l’organisation du complexe de castration. La « partiellisation » du sein est génératrice d’un conflit entre sein maternel et érotique, ainsi qu’entre sein maternel et pénis phallique, et nécessite une opération de refoulement. Le tabou de l’inceste prégénital originel est au cœur de la problématique.