bluuebunny/crossref_metadata_2025_split huggingface dataset:
PARENTS' PSYCHOLOGICAL WELL‐BEING AND PARENTAL SELF‐EFFICACY IN RELATION TO THE FAMILY'S TRIADIC INTERACTION
Authors: Korja Riikka , Piha Jorma , Otava Riia , Lavanchy Scaiola Chloé , Ahlqvist‐Björkroth Sari , Junttila Niina , Aromaa Minna , Räihä Hannele , Study Group Steps 
Published: May 2015

ABSTRACTThe aim of the study was to assess whether a parent's psychological well‐being and/or self‐efficacy relate to interaction within the family. This study is part of a Finnish follow‐up study called Steps to the Healthy Development and Well‐Being of Children (STEPS;). The study group included 120 families. Mother's and father's social anxiety and depression were assessed during pregnancy and at 18 months of the child's age using self‐report questionnaires; the mother's and father's self‐efficacy were assessed at 18 months using a parental self‐efficacy scale validated within the STEPS study. Mother–father–child triadic interaction was studied at 18 months within a Lausanne Triadic Play setting. Results showed that maternal symptoms of depression during pregnancy and maternal social anxiety at 18 months were related to triadic interaction within the family. There was no relation between father's psychological well‐being and triadic interaction within the family. Father's self‐efficacy in teaching tasks and the Mother's self‐efficacy in emotional support were associated with family interaction. The findings suggest that maternal psychological well‐being and self‐efficacy in emotional support may be important components of family triadic interaction whereas paternal self‐efficacy in teaching tasks seems to support family coordination in triadic interaction.
Synthesis and Structure of a New Copper(II) Coordination Polymer Alternately Bridged by Oxamido and Carboxylate Groups: Evaluation of DNA/BSA Binding and Cytotoxic Activities
Authors: Jin Xiao‐Ting , Zheng Kang , Li Yan‐Tuan , Wu Zhi‐Yong , Yan Cui‐Wei 
Published: May 2015

ABSTRACTA new one‐dimensional (1D) copper(II) coordination polymer {[Cu2(dmaepox)(dabt)](NO3)·0.5 H2O}n, where H3dmaepox and dabt denote N‐benzoato‐N′‐(3‐methylaminopropyl)oxamide and 2,2′‐diamino‐4,4′‐bithiazole, respectively, was synthesized and characterized by single‐crystal X‐ray diffraction and other methods. The crystal structure analysis revealed that the two copper(II) ions are bridged alternately by cis‐oxamido and carboxylato groups to form a 1‐D coordination polymer with the corresponding Cu···Cu separations of 5.1946(19) and 5.038(2) Å. There is a three‐dimensional supramolecular structure constructed by hydrogen bonding and π–π stacking interactions in the crystal. The reactivity towards herring sperm DNA (HS‐DNA) and bovine serum albumin (BSA) indicated that the copper(II) polymer can interact with the DNA in the mode of intercalation, and bind to BSA responsible for quenching of tryptophan fluorescence by the static quenching mechanism. The in vitro cytotoxicity suggested that the copper(II) polymer exhibits cytotoxic effects against the selected tumor cell lines.
An automated imaging system for radiation biodosimetry
Authors: Garty Guy , Bigelow Alan W. , Repin Mikhail , Turner Helen C. , Bian Dakai , Balajee Adayabalam S. , Lyulko Oleksandra V. , Taveras Maria , Yao Y. Lawrence , Brenner David J. 
Published: May 2015

ABSTRACTWe describe here an automated imaging system developed at the Center for High Throughput Minimally Invasive Radiation Biodosimetry. The imaging system is built around a fast, sensitive sCMOS camera and rapid switchable LED light source. It features complete automation of all the steps of the imaging process and contains built‐in feedback loops to ensure proper operation. The imaging system is intended as a back end to the RABiT—a robotic platform for radiation biodosimetry. It is intended to automate image acquisition and analysis for four biodosimetry assays for which we have developed automated protocols: The Cytokinesis Blocked Micronucleus assay, the γ‐H2AX assay, the Dicentric assay (using PNA or FISH probes) and the RABiT‐BAND assay. Microsc. Res. Tech. 78:587–598, 2015. © 2015 Wiley Periodicals, Inc.
Cytotoxic chemotherapy for pancreatic neuroendocrine tumors
Authors: Okusaka Takuji , Ueno Hideki , Morizane Chigusa , Kondo Shunsuke , Sakamoto Yasunari , Takahashi Hideaki , Ohno Izumi , Shimizu Satoshi , Mitsunaga Shuichi , Ikeda Masafumi 
Published: May 2015

AbstractAdvanced neuroendocrine tumors are incurable, and most patients will succumb to the disease. Chemotherapies with cytotoxic agents such as streptozocin, 5‐fluorouracil, or temozolomide have been frequently used as drug therapies for neuroendocrine tumors. Streptozocin, which is the only approved cytotoxic agent available for the treatment of this disease in many countries, has been considered a key agent for the treatment of advanced neuroendocrine tumors based on the results of phase III studies. However, the widespread acceptance of streptozocin‐based chemotherapy for this indication has been limited by concerns regarding toxicity. Recent prospective and retrospective studies showed the promising activity of a temozolomide‐based regimen, although an adequate prospective controlled study defining the role of temozolomide in the treatment of neuroendocrine tumors is lacking. The promising activity of cytotoxic agents awaits confirmation; solid evidence‐based recommendations and treatment decisions are needed for the optimal use of chemotherapy against this disease.
Demographic factors and hospital size predict patient satisfaction variance—implications for hospital value‐based purchasing
Authors: McFarland Daniel C. , Ornstein Katherine A. , Holcombe Randall F. 
Published: May 2015

BACKGROUNDHospital Value‐Based Purchasing (HVBP) incentivizes quality performance‐based healthcare by linking payments directly to patient satisfaction scores obtained from Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys. Lower HCAHPS scores appear to cluster in heterogeneous population‐dense areas and could bias Centers for Medicare & Medicaid Services (CMS) reimbursement.OBJECTIVEAssess nonrandom variation in patient satisfaction as determined by HCAHPS.DESIGNMultivariate regression modeling was performed for individual dimensions of HCAHPS and aggregate scores. Standardized partial regression coefficients assessed strengths of predictors. Weighted Individual (hospital) Patient Satisfaction Adjusted Score (WIPSAS) utilized 4 highly predictive variables, and hospitals were reranked accordingly.SETTINGA total of 3907 HVBP‐participating hospitals.PATIENTSThere were 934,800 patient surveys by the most conservative estimate.MEASUREMENTSA total of 3144 county demographics (US Census) and HCAHPS surveys.RESULTSHospital size and primary language (non–English speaking) most strongly predicted unfavorable HCAHPS scores, whereas education and white ethnicity most strongly predicted favorable HCAHPS scores. The average adjusted patient satisfaction scores calculated by WIPSAS approximated the national average of HCAHPS scores. However, WIPSAS changed hospital rankings by variable amounts depending on the strength of the predictive variables in the hospitals’ locations. Structural and demographic characteristics that predict lower scores were accounted for by WIPSAS that also improved rankings of many safety‐net hospitals and academic medical centers in diverse areas.CONCLUSIONSDemographic and structural factors (eg, hospital beds) predict patient satisfaction scores even after CMS adjustments. CMS should consider WIPSAS or a similar adjustment to account for the severity of patient satisfaction inequities that hospitals could strive to correct. Journal of Hospital Medicine 2015;10:503–509. © 2015 Society of Hospital Medicine
Change in T2* relaxation time of Hoffa fat pad correlates with histologic change in a rat anterior cruciate ligament transection model
Authors: Wang Chao‐Ying , Tsai Ping‐Huei , Siow Tiing Yee , Lee Herng‐Sheng , Chang Yue‐Cune , Hsu Yi‐Chih , Chiang Shih‐Wei , Lin Ming‐Huang , Chung Hsiao‐Wen , Huang Guo‐Shu 
Published: May 2015

ABSTRACTThe Hoffa fat pad (infrapatellar fat pad) is a source of post‐traumatic anterior knee pain, and Hoffa disease is a syndrome leading to chronic inflammation of the fat pad. Herein, change in T2* relaxation time of the fat pad was measured in a rodent anterior cruciate ligament transection (ACLX) model in order to (i) examine the causal relationship of anterior cruciate ligament (ACL) deficiency and Hoffa disease and (ii) demonstrate the feasibility of using T2* as an imaging biomarker to monitor disease progression. Three groups of male Sprague Dawley rats (n = 6 each group), received either (i) no intervention; (ii) sham surgery at the right knee; or (iii) right ACLX. T2* relaxation time was measured and histology was examined in the Hoffa fat pad after surgery. At 13 and 18 weeks after surgery, T2* values were significantly higher in the right fat pad than the left (p < 0.001) and significantly higher in the ACLX group than the control and sham groups (p < 0.001). Histology showed fibrosis and degeneration of adipocytes in the right knees of the ACLX group. We conclude that ACL deficiency and Hoffa disease are causally related and that MRI T2* value can serve as an imaging biomarker of Hoffa disease progression. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1348–1355, 2015.
Coordination and symmetry patterns during the drop vertical jump, 6‐months after first‐time lateral ankle sprain
Authors: Doherty Cailbhe , Bleakley Chris , Hertel Jay , Caulfield Brian , Ryan John , Sweeney Kevin , Patterson Matthew R. , Delahunt Eamonn 
Published: May 2015

ABSTRACTTo evaluate the adaptive movement and motor control patterns of a group with a 6‐month history of first‐time lateral ankle sprain (LAS) injury during a drop vertical jump (DVJ) task. Fifty‐one participants with a 6‐month history of first‐time acute LAS injury and twenty controls performed a DVJ task. 3D kinematic and sagittal plane kinetic profiles were plotted for the lower extremity joints of both limbs for the drop jump (phase 1) and drop landing (phase 2) phases of the DVJ. Inter‐limb symmetry and the rate of impact modulation (RIM) relative to bodyweight (BW) during both phases of the DVJ were also determined. LAS participants displayed bilateral increases in knee flexion and an increase in ankle inversion during phases 1 and 2, respectively. They also displayed reduced ankle plantar flexion on their injured limb during both phases of the DVJ (p < 0.05); increased inter‐limb asymmetry of RIM was noted for both phases of the DVJ, while the moment‐of‐force profile exhibited bilaterally greater hip extensor dominance during phase 1. Participants with a 6‐month history of first‐time LAS display some movement patterns consistent with those observed in chronic ankle instability populations during similar tasks. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1537–1544, 2015.
Charge Carrier Transport and Photogeneration in P3HT:PCBM Photovoltaic Blends
Authors: Laquai Frédéric , Andrienko Denis , Mauer Ralf , Blom Paul W. M. 
Published: May 2015

This article reviews the charge transport and photogeneration in bulk‐heterojunction solar cells made from blend films of regioregular poly(3‐hexylthiophene) (RR‐P3HT) and methano­fullerene (PCBM). The charge transport, specifically the hole mobility in the RR‐P3HT phase of the polymer:fullerene photovoltaic blend, is dramatically affected by thermal annealing. The hole mobility increases more than three orders of magnitude and reaches a value of up to 2 × 10−4 cm2 V−1 s−1 after the thermal annealing process as a result of an improved semi‐crystallinity of the film. This significant increase of the hole mobility balances the electron and hole mobilities in a photovoltaic blend in turn reducing space‐charge formation, and this is the most important factor for the strong enhancement of the photovoltaic efficiency compared to an as cast, that is, non‐annealed device. In fact, the balanced charge carrier mobility in RR‐P3HT:PCBM blends in combination with a field‐ and temperature‐independent charge carrier generation and greatly reduced non‐geminate recombination explains the large quantum efficiencies mea­sured in P3HT:PCBM photovoltaic devices.
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Chromatin remodelling and histone mRNA accumulation in bovine germinal vesicle oocytes
Authors: Labrecque R. , Lodde V. , Dieci C. , Tessaro I. , Luciano A. M. , Sirard M. A. 
Published: May 2015

SUMMARYMajor remodelling of the chromatin enclosed within the germinal vesicle occurs towards the end of oocyte growth in mammals, but the mechanisms involved in this process are not completely understood. In bovine, four distinct stages of chromatin compaction—ranging from a diffused state (GV0) to a fully compacted configuration (GV3)—are linked to the gradual acquisition of developmental potential. To better understand the molecular events and to identify mRNA modulations occurring in the oocyte during the GV0‐to‐GV3 transition, transcriptomic analysis was performed with the EmbryoGENE microarray platform. The mRNA abundance of several genes decreased as chromatin compaction increased, which correlates with progressive transcriptional silencing that is characteristic of the end of oocyte growth. On the other hand, the abundance of some transcripts increased during the same period, particularly several histone gene transcripts from the H2A, H2B, H3, H4, and linker H1 family. In silico analysis predicted RNA‐protein interactions between specific histone transcripts and the bovine stem‐loop binding protein 2 (SLBP2), which helps regulate the translation of histone mRNA during oogenesis. These results suggest that some histone‐encoding transcripts are actively stored, possibly to sustain the needs of the embryo before genome activation. This dataset offers a unique opportunity to survey which histone mRNAs are needed to complete chromatin compaction during oocyte maturation and which are stockpiled for the first three cell cycles following fertilization. Mol. Reprod. Dev. 82: 450–462, 2015. © 2015 Wiley Periodicals, Inc.
Active Layer Thickness Prediction on the Western Antarctic Peninsula
Authors: Wilhelm Kelly R. , Bockheim James G. , Kung Samuel 
Published: May 2015

AbstractThe effects of climate change along the climatically sensitive Western Antarctic Peninsula (WAP) on active layer dynamics have just begun to be monitored. But extreme climates and difficult access make borehole installation here challenging. This study was designed to examine the ability of two commonly used, minimally intrusive techniques (the Stefan and Kudryavtsev equations) to predict active layer temperature dynamics and maximum active layer thickness (ALT) on Amsler Island, on the WAP. The ALT in soils and unconsolidated materials was predicted to be between 4.7 and 8.7 m, and between 11.9 and 18.6 m in bedrock, consistent with measurements made in a 14.6 m deep borehole. The thermal model HYDRUS accurately predicted temperature dynamics at several monitored borehole depths. The success of the HYDRUS method indicates that the model can be a useful tool in predicting active layer temperatures and approximating ALTs in regions that are too difficult to install monitoring boreholes. Copyright © 2015 John Wiley & Sons, Ltd.
Antisite defects in nonstoichiometric Lu3Al5O12:Ce ceramic scintillators
Authors: Hu Chen , Liu Shuping , Shi Yun , Kou Huamin , Li Jiang , Pan Yubai , Feng Xiqi , Liu Qian 
Published: May 2015

Antisite defects (ADs) in nonstoichiometric Lu3Al5O12:Ce (LuAG:Ce) were studied systematically by a combination of first‐principles calculation based on density functional theory (DFT), X‐ray diffraction (XRD), and electron spin resonance (ESR) experiments. Calculations illustrated that LuAl,16a AD is dominant in LuAG when an Lu2O3 excess exists. Nonstoichiometric LuAG:Ce ceramic with different Lu2O3 excess were prepared to verify the calculation results. The retrieved XRD lattice constants of Lu2O3 excess LuAG:Ce ceramics fit well with DFT calculation results on LuAl,16a AD model, and the same distorted Ce sites in single crystals were also found in LuAG:Ce ceramics by ESR, which suggests the existence of LuAl,16a ADs and they are dominant in nonstoichiometric LuAG:Ce ceramics, and thus measurable concentrations of ADs were detected in ceramics. This revealed that the formation of ADs is related to both temperature and chemical stoichiometry.LuAl,16a antisite defects and nearest normal Lu sites.
Isotopic disproportionation during hydrogen isotopic analysis of nitrogen‐bearing organic compounds
Authors: Nair Sreejesh , Geilmann Heike , Coplen Tyler B. , Qi Haiping , Gehre Matthias , Schimmelmann Arndt , Brand Willi A. 
Published: May 2015

RationaleHigh‐precision hydrogen isotope ratio analysis of nitrogen‐bearing organic materials using high‐temperature conversion (HTC) techniques has proven troublesome in the past. Formation of reaction products other than molecular hydrogen (H2) has been suspected as a possible cause of incomplete H2 yield and hydrogen isotopic fractionation.MethodsThe classical HTC reactor setup and a modified version including elemental chromium, both operated at temperatures in excess of 1400 °C, have been compared using a selection of nitrogen‐bearing organic compounds, including caffeine. A focus of the experiments was to avoid or suppress hydrogen cyanide (HCN) formation and to reach quantitative H2 yields. The technique also was optimized to provide acceptable sample throughput.ResultsThe classical HTC reaction of a number of selected compounds exhibited H2 yields from 60 to 90 %. Yields close to 100 % were measured for the experiments with the chromium‐enhanced reactor. The δ2H values also were substantially different between the two types of experiments. For the majority of the compounds studied, a highly significant relationship was observed between the amount of missing H2 and the number of nitrogen atoms in the molecules, suggesting the pyrolytic formation of HCN as a byproduct. A similar linear relationship was found between the amount of missing H2 and the observed hydrogen isotopic result, reflecting isotopic fractionation.ConclusionsThe classical HTC technique to produce H2 from organic materials using high temperatures in the presence of glassy carbon is not suitable for nitrogen‐bearing compounds. Adding chromium to the reaction zone improves the yield to 100 % in most cases. The initial formation of HCN is accompanied by a strong hydrogen isotope effect, with the observed hydrogen isotope results on H2 being substantially shifted to more negative δ2H values. The reaction can be understood as an initial disproportionation leading to H2 and HCN with the HCN‐hydrogen systematically enriched in 2H by more than 50 ‰. In the reaction of HCN with chromium, H2 and chromium‐containing solid residues are formed quantitatively. Copyright © 2015 John Wiley & Sons, Ltd.
Leakage‐resilient certificate‐based encryption
Authors: Yu Qihong , Li Jiguo , Zhang Yichen 
Published: May 2015

AbstractCertificate‐based encryption is a new cryptography primitive, which can be used to construct efficient public key infrastructure. However, side‐channel attacks are not considered in certificate‐based encryption. In order to capture these attacks, we formalize security model of certificate‐based encryption with leakage resilience. Furthermore, we present a leakage‐resilient certificate‐based encryption (LR‐CBE) scheme. To the best of our knowledge, this is the first LR‐CBE scheme. Based on decision bilinear Diffie‐Hellman assumption and decision generalized bilinear Diffie‐Hellman assumption, we prove that our scheme is secure against adaptive chosen ciphertext attacks in the random oracle model. Our scheme includes a certificate‐based key encapsulation algorithm and a symmetric encryption algorithm, where the encapsulated information is a symmetric key that is used to encrypt message. In order to obtain leakage‐resilient property, two‐source extractor is used to randomize the symmetric key. The designed scheme can resist entropy leakage. The performance analysis of leakage resilience shows that the relative leakage ratio almost amounts to 1. Copyright © 2015 John Wiley & Sons, Ltd.
Progress of Microfluidics for Biology and Medicine
Authors: Chen Jingdong , Chen Di , Xie Yao , Yuan Tao , Chen Xiang 
Published: May 2015

Abstract
Microfluidics has been considered as a potential technology to miniaturize the conventional equipments and technologies. It offers advantages in terms of small volume, low cost, short reaction time and highthroughput. The applications in biology and medicine research and related areas are almost the most extensive and profound. With the appropriate scale that matches the scales of cells, microfluidics is well positioned to contribute significantly to cell biology. Cell culture, fusion and apoptosis were successfully performed in microfluidics. Microfluidics provides unique opportunities for rare circulating tumor cells isolation and detection from the blood of patients, which furthers the discovery of cancer stem cell biomarkers and expands the understanding of the biology of metastasis. Nucleic acid amplification in microfluidics has extended to single-molecule, high-throughput and integration treatment in one chip. DNA computer which is based on the computational model of DNA biochemical reaction will come into practice from concept in the future. In addition, microfluidics offers a versatile platform for protein-protein interactions, protein crystallization and high-throughput screening. Although microfluidics is still in its infancy, its great potential has already been demonstrated and will provide novel solutions to the high-throughput applications.
Measurement of the Radiographic Anatomy of the Small and Ring Metacarpals using Computerized Tomographic Scans
Authors: Rivlin Michael , Kim Nayoung , Lutsky Kevin F. , Beredjiklian Pedro K. 
Published: May 2015

Background To date, only plain radiographic definitions of normal anatomical parameters have been described. Our study aims to describe normal anatomic measurements of small and ring metacarpals using a novel digital reconstruction technique based on raw CT image data. We hypothesize that current plain radiographic data incorrectly describes normal metacarpal anatomy in the lateral plane. Methods Thirty-five scans of the small and 30 scans of the ring metacarpals form the basis for this study. Using a custom digital 3D image reformatting software, CT sections were reconstructed in the plane of each studied metacarpal. The 3D images were converted to sagittal and coronal weighted projections to represent lateral and posteroanterior (PA) 2D images that are equivalent to “perfect orthogonal” radiographs. Using a customized image measurement program, shaft lengths, shaft-bending angle (SBA), and capital-axis angle (CAA) were measured. Results Our results show that CAA averaged 14 and 12° in the ring and small metacarpals, respectively. Apex dorsal SBA averaged 12 and 10° in the ring and small metacarpals, respectively. On the PA images, the shafts are nearly straight. In contrast to prior reported values, we found the CAA to be less acute and the metacarpal curvature less pronounced on the lateral projection. We also demonstrated that much of the metacarpal apex dorsal bend is in the shaft itself. Conclusion Normal anatomic parameters of metacarpals are based primarily on radiographic data, and as such are limited due to bony overlap in the lateral plane, as well as imperfect radiographic projections that are known to distort anatomical relationships. This novel method of image reconstruction eliminates metacarpal overlap and defines precise anatomical reference for metacarpals.