bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cervical clamp with ring forceps to prevent prolapse of an intrauterine balloon in the management of postpartum hemorrhage
Authors: Kawamura Akeo , Kondoh Eiji , Hamanishi Junzo , Kawamura Yosuke , Kusaka Kyoko , Ueda Akihiko , Kawasaki Kaoru , Fujita Kohei , Mogami Haruta , Konishi Ikuo 
Published: October 2012

AbstractAn intrauterine balloon tamponade is a simple but highly effective method for the management of postpartum hemorrhage. However, treatment failure can occur due to prolapse of an intrauterine balloon into the vagina. We present two cases with a successful maneuver in maintaining the intrauterine placement of the balloon by clamping the cervix with two ring forceps in the management of postpartum hemorrhage. Although the balloon was initially expelled through a dilated cervix, a cervical clamp using ring forceps prevented displacement of the balloon, and the hemorrhage ceased. Clamping the cervix with two ring forceps to retain the balloon can be a simple and readily available approach to consider when an intrauterine balloon tamponade does not work due to its expulsion.
Primary Ewing's sarcoma of vulva: A case report and a review of the literature
Authors: Che Shao‐Min , Cao Pei‐Long , Chen Hong‐Wei , Liu Zi , Meng Du 
Published: October 2012

AbstractEwing sarcomas/peripheral primitive neuroectodermal tumors (ES/pPNET) are extremely rare in the vulva. A review of the literature reveals only 14 previously reported possible cases. Here we reported a case of primary extraskeletal Ewing's sarcoma (EES) of the vulva in a 37‐year‐old woman. Characteristic histologic features of ES/pPNET were present in this case, including a monomorphic population of small round blue cells with cytoplasmic glycogen confirmed by periodic acid‐Schiff, membrane staining with CD99 and nuclear staining with FLI‐1. After surgery, the patient was found to have pulmonary metastasis and then received six cycles of polychemotherapy. She is still alive with stable disease after 1 year of follow up. Our findings underline the crucial role of immunohistochemical techniques in the differential diagnosis of small round cell tumors in these unusual locations. We also give a summary about the clinical and pathological features of the primary ES/pPNET in the vulva reported previously in the literature.
Dietary practices of Saudi women during puerperium
Authors: Saadia Zaheera , Roshdy Salah , Sagir Faiza , Abidin Shazia 
Published: October 2012

AbstractAimPoor maternal health sometimes can be a consequence of practicing different myths during puerperium. This cross‐sectional study describes the practice of different myths regarding diet among Saudi women.Material and MethodsThe study comprised women attending the postnatal clinic at the Mother and Child Hospital in Buraidah from January to December 2011.ResultsAlmost 65.9% of women were using a combination of herbs such as ginger (zingiber officinale), hilba (fenugreek) and black seeds (nigella sativa). The multinomial logistic regression of herbs on age, education, occupation, parity and mode of delivery was statistically significant (χ2 [48] = 214.645, P < 0.001). Hilba was more commonly used by women with instrumental delivery. It was common for women to avoid different fruits and vegetables (33.89%). Eggs were avoided by 16.5% of women and 11% avoided cold drinks. The multinomial logistic regression of diet on age, education, occupation, parity and mode of delivery was statistically significant (χ2 [72] = 389.861, P < 0.001). Individuals below college level education were more likely to avoid fruits, vegetables and cold drinks in their diet.ConclusionHealth education programs are needed to improve knowledge about dietary malpractices during puerperium. This may help eliminate myths regarding avoidance of certain dietary components.
Distribution of nuchal translucency thickness in Japanese fetuses
Authors: Hasegawa Junichi , Nakamura Masamitsu , Hamada Shoko , Matsuoka Ryu , Ichizuka Kiyotake , Sekizawa Akihiko , Okai Takashi 
Published: October 2012

AbstractAimTo establish reference values for the nuchal translucency (NT) thickness in Japanese fetuses.Material and MethodsUltrasonographic measurements of the crown‐rump length (CRL) and NT were performed from 11 to 13 + 6 weeks of gestation in consecutive Japanese fetuses examined during prenatal visits between February 2011 and January 2012. The median, 5th and 95th percentiles of the NT thickness with 5 mm intervals of the CRL were confirmed.ResultsA total of 970 cases were enrolled in the study. The median NT thickness for a CRL between 45 and 80 mm ranged from 1.2 mm to 1.9 mm, and the 95th percentile of these values ranged from 2.1 mm to 3.2 mm, respectively.ConclusionThe reference values for the NT thickness in Japanese fetuses were determined. These values should be useful for fetal biometry, morphological assessment and first trimester screening for chromosomal abnormalities in Japan.
Molecular phylogeny of the Helicodontidae and Trissexodontidae (Gastropoda)
Authors: Gómez‐Moliner Benjamín J. , Elejalde Arantzazu M. , Arrébola Jose R. , Puente Ana I. , Martínez‐Ortí Alberto , Ruiz Antonio , Madeira María J. 
Published: October 2012

Gómez‐Moliner, B.J., Elejalde, A.M., Arrébola, J.R., Puente, A.I., Martínez‐Ortí, A., Ruiz, A. & Madeira, MJ. (2012). Molecular phylogeny of the Helicodontidae and Trissexodontidae (Gastropoda). —Zoologica Scripta, 00, 000–000.In this study, we present a molecular phylogeny of the Trissexodontidae and Helicodontidae obtained by means of Maximum Parsimony, Neighbor Joining, Maximum Likelihood and Bayesian analyses of DNA sequences. Nearly 3 KB of sequence data of two mitochondrial genes (COI, 16S rDNA) and the nuclear rRNA gene cluster including ITS‐1, the 3′end of the 5.8S gene, the complete ITS‐2 region and 5′ end of the large subunit 28S were used to reconstruct the phylogeny of these two families. Monophyly of Trissexodontidae and Helicodontidae at the family level is well supported. A new classification of the genera in the Trissexodontidae is proposed. It includes two subfamilies: Gittenbergeriinae (monotypic for Gittenbergeria turriplana) and Trissexodontinae. The latter includes three strongly supported tribes: (i) Trissexodontini, including Mastigophallus, Trissexodon, Oestophorella and Suboestophora; (ii) Oestophorini, with Oestophora; and (iii) Caracollinini, with Caracollina, Gasulliella, Gasullia and Hatumia. The polytypic Oestophora and Suboestophora are recovered as two monophyletic genera. The anatomy of the auxiliary copulatory organs of the reproductive system is coherent with the new taxonomic interpretation of the Trissexodontidae. Further work, including some more taxa is needed to delimitate subfamilies within Helicodontidae. Finally, the addition of some sequences of other Helicoidea shows that the genus Ciliella is not closely related to Trissexodontidae, being grouped within the Hygromiidae, instead.
Diethylstilbestrol in castration‐resistant prostate cancer
Authors: Wilkins Anna , Shahidi Mehdi , Parker Chris , Gunapala Ranga , Thomas Karen , Huddart Robert , Horwich Alan , Dearnaley David 
Published: October 2012

Study Type – Therapy (case series)Level of Evidence 4What's known on the subject? and What does the study add?Diethylstilbestrol (DES) was the first hormone treatment used for prostate cancer and has also shown effectiveness in castration‐resistant disease in small studies; however, concerns over thromboembolic toxicity have restricted its use in the past.Over 200 elderly men with castration‐resistant prostate cancer were treated with 1–3 mg of DES, given with 75 mg aspirin and breast bud irradiation. Almost 30% of men showed a significant PSA response and the median time to PSA progression was 4.6 months. Almost 20% of patients with pain had a significant analgesic benefit. The most important toxicity was thromboembolism in 10% of men. Overall the drug has an acceptable toxicity profile and offers a palliative benefit in frail elderly men who may not be fit for chemotherapy.OBJECTIVE
To assess the efficacy and toxicity of diethylstilbestrol (DES) in the management of castration‐resistant prostate cancer (CRPC).
PATIENTS AND METHODS
A total of 231 patients with CRPC received treatment with DES at the Royal Marsden Hospital between August 1992 and August 2000.
The median pre‐treatment prostate‐specific antigen (PSA) level was 221 ng/mL.
DES was used at a dose of 1–3 mg daily, with aspirin 75 mg.
The primary endpoint was PSA response rate.
RESULTS
The PSA response rate (using PSA Working Group criteria) was 28.9%.
The median time to PSA progression was 4.6 months.
Of patients with bone pain, 18% had an improvement in their European Organisation for the Research and Treatment of Cancer pain score.
Thromboembolic complications were seen in 9.9% of all patients.
CONCLUSIONS
DES has significant activity in CRPC and can be of palliative benefit.
DES has an acceptable toxicity profile in the management of patients with symptomatic CRPC when used at a dose of 1–3 mg, combined with aspirin and prophylactic breast bud radiotherapy.
Mapping black carbon content in topsoils of central France
Authors: Paroissien J.‐B. , Orton T. G. , Saby N. P. A. , Martin M. P. , Jolivet C. C. , Ratie C. , Caria G. , Arrouays D. 
Published: October 2012

AbstractBlack Carbon (BC) is an important carbon pool due to its relative stability in soil. Thus, it is essential to determine the amount of BC in soil to have a better understanding of the global carbon cycle. The spatial distribution of BC was determined in the central region of France in relation to the main controlling factors. BC was measured for topsoil at 158 sites in the French soil monitoring network on a regular 16 × 16‐km grid. A linear mixed model (LMM) which included fixed effects (linear relationships between BC content and covariates) and spatially correlated random effects was used for mapping BC to aid explanation. Covariates were selected from a set of factors linked to the BC cycle using the Akaike Information Criterion (AIC). The results show high variability in BC content with a minimum of 0.9%, a maximum of 32% and an average of 5.3% for total organic carbon. The fine‐earth fraction and clay content gave the best statistical explanation for the spatial distribution of BC. Data on these covariates were not available in total for the whole study area, and therefore we reselected covariates using the fine‐earth amount and density of fires from burning crop residues.
Effects of grass vegetation strips on soil conservation and crop yield under rainfed conditions in theIndian sub‐Himalayas
Authors: Ghosh B. N. , Dogra P. , Bhattacharyya R. , Sharma N. K. , Dadhwal K. S. 
Published: October 2012

AbstractVegetation strips (VS) along with conservation tillage, application of organic amendments and weed mulching improve crop yields by reducing run‐off and topsoil erosion. To investigate these issues, an experiment was conducted under rainfed conditions using grassVSfor four and a half years (June 2007 to October 2011) at Dehradun, Uttarakhand, in the Indian Himalayan region.VSwere incorporated in the experimental plots (Entisols) in a randomized complete block design in permanent 100 × 20 m (2000 m2) plots with a 2% slope to evaluate the effects of vegetation strips on run‐off, soil loss and crop yield. Three treatments were evaluated: (i) withoutVSwith recommendedNPKunder conventional tillage, (ii) panicum asVSwith recommendedNPKunder conventional tillage and (iii) palmarosa+ that consists of palmarosa asVSalong with organic amendments (farmyard manure, vermicompost and poultry manure) and weed mulch under minimum tillage. The results show that soil loss and run‐off were significantly lower (P < 0.05) in plots under palmarosa+ than withoutVStreatment. Mean soil loss of 3.4, 5.2 and 7.1 t/ha was recorded from palmarosa+, panicum and withoutVStreated plots, respectively. Mean run‐off was 234, 356 and 428 mm from plots under palmarosa+, panicum and withoutVS, respectively. Maize yield was lower on the plots under palmarosa+ compared with panicum, but significantly higher (P < 0.05) than without a strip. The succeeding rainfed wheat yield was significantly greater in plots under palmarosa+ than in the initial years. The wheat yield equivalent was significantly higher in plots under palmarosa+ followed by panicum and withoutVS. Thus, vegetation strips are recommended for wider adoption to reduce run‐off and soil loss and to increase crop yield. The long‐term goal is to achieve a palmarosa+ system (palmarosa as a vegetation strip along with organic amendments, farmyard manure, vermicompost and poultry manure) and weed mulch under minimum tillage.
Measurement of intra‐abdominal pressure in dogs and cats
Authors: Smith Shelley E. , Sande Allison A. 
Published: October 2012

AbstractObjectiveTo review and summarize the human and veterinary literature on intra‐abdominal pressure measurement techniques.Data SourcesHuman and veterinary clinical studies, research articles, reviews, and textbooks with no date restrictions with a focus on techniques for intra‐abdominal pressure (IAP) measurement and their limitations.Human Data SynthesisHuman literature has established the intravesicular method as the gold standard for indirect measurement of IAP. However, current research has explored the intragastric method as a valid alternative. Recently, debate has focused on the shortcomings of the various measurement methods.Veterinary Data SynthesisEarly human literature using dogs as models contributed to the original data for IAP measurements in small animals. Since that time, a number of clinical studies and 1 case report have contributed to that original information. A reference interval for IAP measured by the intravesicular method has recently been determined in healthy cats.ConclusionsFurther studies investigating IAP in critically ill veterinary patients are required to establish the optimal technique for this measurement in veterinary medicine.
Preoperative thoracic radiographic findings in dogs presenting for gastric dilatation‐volvulus (2000–2010): 101 cases
Authors: Green Jaime L. , Cimino Brown Dorothy , Agnello Kimberly A. 
Published: October 2012

AbstractObjectiveTo identify the incidence of clinically significant findings on preoperative thoracic radiographs in dogs with gastric dilatation‐volvulus (GDV) and to determine if those findings are associated with survival.DesignRetrospective study from 2000 to 2010.SettingUrban university small animal teaching hospital.AnimalsOne hundred and one dogs diagnosed with GDV that had thoracic radiographs obtained preoperatively, and medical records available with the following information available: signalment, time of presentation, respiratory status, plasma lactate, presence of cardiac arrhythmias, reason for thoracic radiographs, radiographic findings, and outcome.InterventionsNone.ResultsFindings on preoperative thoracic radiographs included small vena cava (40%), esophageal dilation (39%), microcardia (34%), aspiration pneumonia (14%), cardiomegaly (5%), pulmonary nodule (4%), pulmonary edema (2%), sternal lymphadenopathy (1%), and pulmonary bullae (1%). Eighty‐four percent of dogs (85 out of 101) survived to discharge. Dogs without cardiomegaly on presenting thoracic radiographs had a 10.2 greater odds of surviving to discharge.ConclusionsThe most common findings on preoperative thoracic radiographs include esophageal dilation, microcardia, and a small vena cava while the incidence of pulmonary nodules was low. A negative association between survival and presence of cardiomegaly on preoperative thoracic radiographs in dogs with GDV supports the need to obtain these images for prognostic information in spite of the emergency surgical nature of the GDV. The main limitations of this study include the possibilities of type I and type II errors, the retrospective nature of the study, and the lack of well‐defined criteria for obtaining thoracic radiographs.
Use of intravenous lipid therapy in three cases of feline permethrin toxicosis
Authors: Haworth Mark D. , Smart Lisa 
Published: October 2012

AbstractObjectiveTo describe the use of intravenous lipid emulsion (IVLE) as an adjunctive therapy in 3 cats with permethrin toxicosis.Case Series SummaryThree cats with permethrin toxicosis were treated withIVLEin addition to the current accepted treatment regime. All 3 cats demonstrated a subjective rapid clinical improvement after the administration ofIVLE, with no adverse reactions observed.New or Unique Information ProvidedThis is the first reported use ofIVLEfor feline permethrin toxicosis, with encouraging results. A possible reduction in costs associated with treatment may contribute to a reduction in euthanasia. Further investigation of the use ofIVLEs in permethrin toxicosis is warranted.
Retrospective evaluation of toxicosis from selective serotonin reuptake inhibitor antidepressants: 313 dogs (2005–2010)
Authors: Thomas Danielle E. , Lee Justine A. , Hovda Lynn R. 
Published: October 2012

AbstractObjectiveTo evaluate a clinical population of dogs exposed to selective serotonin reuptake inhibitor (SSRI) antidepressant medications and describe the clinical findings, epidemiological characteristics, outcome, and prognosis.DesignRetrospective study (February 1, 2005–August 31, 2010).SettingAnimal poison control helpline.AnimalsThree hundred thirteen dogs with presumed SSRI toxicosis.InterventionsNone.Measurements and Main ResultsDogs with presumptive SSRI medication toxicosis identified by a review of the electronic database of Pet Poison Helpline, an animal poison control center, were evaluated. No clinical signs were reported in 76.3% (239/313) of cases. The remaining 23.6% (74/313) of cases demonstrated the following clinical signs: neurological 79.7% (59/74), gastrointestinal 25.6% (19/74), cardiovascular 9.5% (7/74), respiratory 8.2% (6/74), and thermoregulatory 6.7% (5/74). Of the dogs exhibiting neurological signs, 62.7% (37/59) showed depression, 37.2% (22/59) showed hyperactivity, 10.1% (6/59) exhibited ataxia, and 1.7% (1/59) showed other miscellaneous signs (eg, hyperesthesia). There was a significant difference between the dose ingested by symptomatic and asymptomatic dogs for fluoxetine (P = 0.0039), but not with any other SSRI. Ninety‐four patients were confirmed to have received veterinary care. In cases where duration of veterinary care was determined (55/313), 67.2% (37/55) of dogs were hospitalized and 32.7% (18/55) treated as outpatients. The average duration of hospitalization was 18.5 hours, excluding outpatient visits. Of those patients that had complete follow‐up information available (136/313), overall survival was 100%.ConclusionsThe overall prognosis for animals with SSRI toxicosis is excellent with veterinary attention. Central nervous system depression was the most common clinical sign associated with SSRI toxicosis.
Expression of IL‐24 and IL‐24 receptors in human wound tissues and the biological implications of IL‐24 on keratinocytes
Authors: Bosanquet David C. , Harding Keith G. , Ruge Fiona , Sanders Andrew J. , Jiang Wen G. 
Published: October 2012

AbstractInterleukin (IL)‐24, also known as melanoma differentiation‐associated gene‐7, is a cytokine initially identified from cancerous cells and expressed in a range of cell types. It is a regulator of cell differentiation, growth, and apoptosis, and a promising anticancer agent. IL‐24 acts via its heterodimic receptors: the IL‐20R1 and IL‐20R2 complex and the IL‐22R1 and IL‐20R2 complex. There is limited information on the effect of IL‐24 in wound healing. Human acute and chronic wound tissues were used to analyze the transcript levels and histological staining of IL‐24 and the IL‐24 receptors. The biological response of human keratinocytes to recombinant human IL‐24 was evaluated using electric cell‐substrate impedance sensing‐based methods in conjunction with inhibitors to candidate signaling pathways. IL‐24 significantly slowed the migration of keratinocytes (p = 0.01), with only a marginal effect on cellular adhesion. The inhibitory effect of IL‐24 on migration was completed reversed following addition of an AKT inhibitor (p = 0.004) but not an SMAD3 pathway inhibitor. Human chronic wound tissues showed raised levels of both IL‐24 (p = 0.003) and its receptor (p = 0.0305) compared with acute wound tissues. We conclude that IL‐24 appears to promote wound chronicity via its inhibitory effect on the migratory behavior of human keratinocytes, mediated through an AKT‐dependent pathway.
Predictive validity of granulation tissue color measured by digital image analysis for deep pressure ulcer healing: a multicenter prospective cohort study
Authors: Iizaka Shinji , Kaitani Toshiko , Sugama Junko , Nakagami Gojiro , Naito Ayumi , Koyanagi Hiroe , Konya Chizuko , Sanada Hiromi 
Published: October 2012

AbstractThis multicenter prospective cohort study examined the predictive validity of granulation tissue color evaluated by digital image analysis for deep pressure ulcer healing. Ninety‐one patients with deep pressure ulcers were followed for 3 weeks. From a wound photograph taken at baseline, an image representing the granulation red index (GRI) was processed in which a redder color represented higher values. We calculated the average GRI over granulation tissue and the proportion of pixels exceeding the threshold intensity of 80 for the granulation tissue surface (%GRI80) and wound surface (%wound red index 80). In the receiver operating characteristics curve analysis, most GRI parameters had adequate discriminative values for both improvement of the DESIGN‐R total score and wound closure. Ulcers were categorized by the obtained cutoff points of the average GRI (≤80, >80), %GRI80 (≤55, >55–80, >80%), and %wound red index 80 (≤25, >25–50, >50%). In the linear mixed model, higher classes for all GRI parameters showed significantly greater relative improvement in overall wound severity during the 3 weeks after adjustment for patient characteristics and wound locations. Assessment of granulation tissue color by digital image analysis will be useful as an objective monitoring tool for granulation tissue quality or surrogate outcomes of pressure ulcer healing.
A multifunctional in situ–forming hydrogel for wound healing
Authors: Du Lina , Tong Li , Jin Yiguang , Jia Junwei , Liu Yangpu , Su Chang , Yu Shanjiang , Li Xin 
Published: October 2012

AbstractIn this study, a multifunctional in situ–forming hydrogel (MISG) was prepared as a wound dressing designed to stop bleeding, inhibit inflammation, relieve pain, and improve healing. A mixture of poloxamers 407 and 188 was used for the matrix of the MISG. Other ingredients include aminocaproic acid (to stop bleeding), povidone iodine (anti‐infective), lidocaine (pain relief), and chitosan (to enhance wound healing and regeneration). The incipient gelation temperature of the MISG was modified by varying the poloxamer concentration. Poloxamer cytotoxicity was evaluated in addition to the effect of the MISG on hemostasis in rabbits, pain relief in mice, bacteriostasis in vitro, and wound healing. The optimal MISG matrix consisted of 30% (w/v) poloxamer (407/188, 1 : 1, w/w) solution and was able to change to a gel within 10 minutes at 37 °C. The poloxamer solution had no cytotoxicity in fibroblasts. Compared to sterile gauze alone, the MISG significantly shortened average hemostasis time and decreased bleeding. The hydrogel showed strong bacteriostatic action similar to povidone iodine solution. It markedly increased the pain threshold and accelerated wound healing compared to the gauze. The MISG is a promising formulation for wound healing in emergency situations.