bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the genetic association of HCP5,SPATA2,TNIP1,TNFAIP3 and COG6 with psoriasis in Chinese population
Authors: Li X.‐L. , Yu H. , Wu G.‐S. 
Published: September 2014

SummaryPsoriasis is a chronic inflammatory skin disease occurred under the interaction of genetic and environmental factors. The genes HLA complex P5 (HCP5), spermatogenesis associated 2 (SPATA2), tumour necrosis factor alpha‐induced protein 3 (TNFAIP3), TNFAIP3‐interacting protein 1 (TNIP1) and the component of oligomeric Golgi complex 6 (COG6) were reported to be associated with psoriasis in western populations by genome‐wide association studies. The aim of this study was to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2 and COG6 genes were genetic risk factors for psoriasis in Chinese population. One single nucleotide polymorphism (SNP) from each gene was evaluated using Chinese patients with psoriasis (n = 201) and controls (n = 300). The results demonstrated that SNPs rs2395029, rs17728338 and rs610604 from the HCP5, TNIP1 and TNFAIP3 genes, respectively, were associated with psoriasis in the studied population at both genotype level and allelic level (P < 0.05). Thus, the data suggested that HCP5, TNIP1 and TNFAIP3 may play a role in common pathogenic of psoriasis in Chinese and confer risk factors for psoriasis in various ethnic populations. These results provide potential makers for diagnosing, treating and preventing the psoriasis.
Energy‐Transfer Modulation for Enhanced Photocatalytic Activity of Near‐Infrared Upconversion Photocatalyst
Authors: Zheng Binbin , Guo Qiangbing , Wang Di , Zhang Hao , Zhu Yifei , Zhou Shifeng 
Published: September 2014

One of the major challenges of near‐infrared upconversion photocatalyst concerns strengthening the cooperation between Rare‐earth (RE) ions and semiconductor materials for enhancing NIR photocatalytic activity. Herein, the basic energy‐transfer (ET) process between RE ions and semiconductor materials is discussed and the appropriate mode, nonradiative ET, is proposed for efficiently coupling them. As an example, a novel NIR‐based UC photocatalyst, CaIn2O4:Yb3+,Tb3+ was designed and successfully fabricated, which exhibited high photocatalytic activity under 980 nm irradiation. The present report highlights the potential of ET tuning between RE ions and semiconductors toward high performance of NIR photocatalysis.
Constructing a high‐density linkage map for Gossypium hirsutum × Gossypium barbadense and identifying QTLs for lint percentage
Authors: Shi Yuzhen , Li Wentan , Li Aiguo , Ge Ruihua , Zhang Baocai , Li Junzhi , Liu Guangping , Li Junwen , Liu Aiying , Shang Haihong , Gong Juwu , Gong Wankui , Yang Zemao , Tang Feiyü , Liu Zhi , Zhu Weiping , Jiang Jianxiong , Yu Xiaonan , Wang Tao , Wang Wei , Chen Tingting , Wang Kunbo , Zhang Zhengsheng , Yuan Youlu 
Published: September 2014

AbstractTo introgress the good fiber quality and yield from Gossypium barbadense into a commercial Upland cotton variety, a high‐density simple sequence repeat (SSR) genetic linkage map was developed from a BC1F1 population of Gossypium hirsutum × Gossypium barbadense. The map comprised 2,292 loci and covered 5115.16 centiMorgan (cM) of the cotton AD genome, with an average marker interval of 2.23 cM. Of the marker order for 1,577 common loci on this new map, 90.36% agrees well with the marker order on the D genome sequence genetic map. Compared with five published high‐density SSR genetic maps, 53.14% of marker loci were newly discovered in this map. Twenty‐six quantitative trait loci (QTLs) for lint percentage (LP) were identified on nine chromosomes. Nine stable or common QTLs could be used for marker‐assisted selection. Fifty percent of the QTLs were from G. barbadense and increased LP by 1.07%–2.41%. These results indicated that the map could be used for screening chromosome substitution segments from G. barbadense in the Upland cotton background, identifying QTLs or genes from G. barbadense, and further developing the gene pyramiding effect for improving fiber yield and quality.
Organelle trafficking, the cytoskeleton, and pollen tube growth
Authors: Cai Giampiero , Parrotta Luigi , Cresti Mauro 
Published: September 2014

AbstractThe pollen tube is fundamental for the reproduction of seed plants. Characteristically, it grows relatively quickly and uni‐directionally (“polarized growth”) to extend the male gametophyte to reach the female gametophyte. The pollen tube forms a channel through which the sperm cells move so that they can reach their targets in the ovule. To grow quickly and directionally, the pollen tube requires an intense movement of organelles and vesicles that allows the cell's contents to be distributed to sustain the growth rate. While the various organelles distribute more or less uniformly within the pollen tube, Golgi‐released secretory vesicles accumulate massively at the pollen tube apex, that is, the growing region. This intense movement of organelles and vesicles is dependent on the dynamics of the cytoskeleton, which reorganizes differentially in response to external signals and coordinates membrane trafficking with the growth rate of pollen tubes.Giampiero Cai
Effects of rare earth element lanthanum on rumen methane and volatile fatty acid production and microbial flora in vitro
Authors: Zhang T. T. , Zhao G. Y. , Zheng W. S. , Niu W. J. , Wei C. , Lin S. X. 
Published: September 2014

SummaryThe objectives of the trial were to study the effects of rare earth element (REE) lanthanum (La) on the in vitro rumen methane (CH4) and volatile fatty acid (VFA) production and the microbial flora of feeds. Four feed mixtures with different levels of neutral detergent fibre (NDF), that is 20.0% (I), 31.0% (II), 41.9% (III) and 52.7% (IV), were formulated as substrates. Five levels of LaCl3, that is 0, 0.4, 0.6, 0.8 and 1.0 mmol/kg dry matter (DM), were added to the feed mixtures, respectively, as experimental treatments in a two‐factor 5 × 4 randomized design. The in vitro incubation lasted for 24 h. The results showed that supplementing LaCl3 increased the total gas (p < 0.001) production and tended to increase the total VFA production (p = 0.072) and decreased the CH4 production (p = 0.001) and the ratios of acetate/propionate (p = 0.019) and CH4/total VFA (p < 0.001). Interactions between LaCl3 and NDF were significant in total gas production (p = 0.030) and tended to be significant in CH4 production (p = 0.071). Supplementing LaCl3 at the level of 0.8 mmol/g DM decreased the relative abundance of methanogens and protozoa in the total bacterial 16S rDNA analysed using the real‐time PCR (p < 0.0001), increased F. succinogenes (p = 0.0003) and decreased R. flavefaciens (p < 0.0001) whereas did not affect R. albus and anaerobic fungi (p > 0.05). It was concluded that LaCl3 decreased the CH4 production without negatively affecting feed digestion through manipulating rumen microbial flora when feed mixtures with different levels of NDF were used as substrates.
Population structure and conservation status of the red gorgonian Paramuricea clavata (Risso, 1826) in the Eastern Adriatic Sea
Authors: Kipson Silvija , Linares Cristina , Čižmek Hrvoje , Cebrián Emma , Ballesteros Enric , Bakran‐Petricioli Tatjana , Garrabou Joaquim 
Published: September 2014

AbstractGorgonians are important structuring species of the Mediterranean hard‐bottom communities that are threatened by disturbances such as increasing seawater temperature, mucilaginous events and destructive fishing, among others. In this study we assessed for the first time the population structure and conservation status of one of the most common gorgonians in the Eastern Adriatic Sea, the red gorgonian Paramuricea clavata. During late spring 2009, nine populations dwelling between 30 and 50 m depth were examined by SCUBA diving along 200 km of the Croatian coastline. The density ranged between 7 and 20 colonies·m−2. The mean and maximum colony heights were 31.2 ± 22.7 cm (±SD) and 138 cm, respectively. Two main patterns of P. clavata size frequency distributions were observed: the first one with a higher proportion of juveniles (~30%) observed mostly in the northernmost populations, and the second one with a higher proportion of larger colonies (>25% of colonies >40 cm in height). Regarding the disturbance impact level, the proportion of healthy colonies (with <10% of injured surface) was high in almost all of the studied populations (>60%) and the mean extent of injury (i.e. denuded axis or epibiosis) was 9.7 ± 4% (±SD), indicating low impacts. Contrasting population size structures with high recruitment in mature populations provides new insights into the demographic structure of the Mediterranean gorgonian forests dwelling in their upper bathymetric range (<50 m depth). Furthermore, these size structures and the low impact levels suggest a current favorable conservation status of the studied populations in the Eastern Adriatic Sea and provide a baseline for their monitoring in the future.
The Pain Self‐Efficacy Questionnaire: Cross‐Cultural Adaptation into Italian and Assessment of Its Measurement Properties
Authors: Chiarotto Alessandro , Vanti Carla , Ostelo Raymond W. , Ferrari Silvano , Tedesco Giuseppe , Rocca Barbara , Pillastrini Paolo , Monticone Marco 
Published: September 2014

AbstractThe Pain Self‐Efficacy Questionnaire (PSEQ) is a patient self‐reported measurement instrument that evaluates pain self‐efficacy beliefs in patients with chronic pain. The measurement properties of the PSEQ have been tested in its original and translated versions, showing satisfactory results for validity and reliability. The aims of this study were 2 fold as follows: (1) to translate the PSEQ into Italian through a process of cross‐cultural adaptation, (2) to test the measurement properties of the Italian PSEQ (PSEQ‐I). The cross‐cultural adaptation was completed in 5 months without omitting any item of the original PSEQ. Measurement properties were tested in 165 patients with chronic low back pain (CLBP) (65% women, mean age 49.9 years). Factor analysis confirmed the one‐factor structure of the questionnaire. Internal consistency (Cronbach's α = 0.94) and test–retest reliability (ICCagreement = 0.82) of the PSEQ‐I showed good results. The smallest detectable change was equal to 15.69 scale points. The PSEQ‐I displayed a high construct validity by meeting more than 75% of a priori hypotheses on correlations with measurement instruments assessing pain intensity, disability, anxiety, depression, pain catastrophizing, fear of movement, and coping strategies. Additionally, the PSEQ‐I differentiated patients taking pain medication or not. The results of this study suggest that the PSEQ‐I can be used as a valid and reliable tool in Italian patients with CLBP.
Risk Factors for Chronic Saphenous Neuralgia Following Coronary Artery Bypass Graft Surgery Utilizing Saphenous Vein Grafts
Authors: Hakim Sameh M. , Narouze Samer N. 
Published: September 2014

AbstractObjectivesThe aim of this trial was to determine risk factors for chronic saphenous neuralgia (SN) following harvesting of the great saphenous vein (GSV) for coronary artery bypass graft (CABG) surgery.MethodsIn a prospective observational trial, 526 patients with no history of chronic painful disorders or surgery in the lower limbs were followed up for 13 weeks after undergoing CABG surgery in which GSV grafts were used. The primary outcome measure was persistence of clinically significant pain of neuropathic type in the territory supplied by the saphenous nerve beyond 12 weeks after surgery.ResultsEighty‐one (15.4%) patients consistently had probable neuropathic pain of clinically significant severity throughout the follow‐up period and were labeled as suffering from chronic SN. Multivariable binary logistic regression analysis showed that younger age (OR, 0.92; 95% CI, 0.88–0.95; P‐value, < 0.0001), female gender (OR, 2.28; 95% CI, 1.21–4.29; P‐value, 0.011), higher body mass index (OR, 1.25; 95% CI, 1.17–1.35; P‐value, < 0.0001), diabetes mellitus (OR, 2.13; 95% CI, 1.13–4.01; P‐value, 0.020), distal‐to‐proximal dissection of the GSV (OR, 7.28; 95% CI, 3.62–14.66; P‐value, < 0.0001), and closure of the leg wound in two layers (OR, 3.28; 95% CI, 1.81–5.95; P‐value, 0.0001) were independent risk factors for chronic SN.ConclusionsChronic SN after CABG surgery utilizing GSV grafts is not uncommon. Risk factors identified in this trial are younger age, female gender, higher body mass index, diabetes mellitus, distal‐to‐proximal dissection of the GSV, and closure of the leg wound in two layers.
Risk factors for early and late biliary complications in pediatric liver transplantation
Authors: Lüthold Samuel C. , Kaseje Neema , Jannot Anne‐Sophie , Mentha Gilles , Majno Pietro , Toso Christian , Belli Dominique C. , McLin Valérie A. , Wildhaber Barbara E. 
Published: September 2014

AbstractBC are a common source of morbidity after pediatric LT. Knowledge about risk factors may help to reduce their incidence. Retrospective analysis of BC in 116 pediatric patients (123 LT) (single institution, 05/1990–12/2011, medium follow‐up 7.9 yr). One‐, five‐, and 10‐yr survival was 91.1%, no patient died of BC. Prevalence and risk factors for anastomotic and intrahepatic BC were examined. There were 29 BC in 123 LT (23.6%), with three main categories: 10 (8.1%) primary anastomotic strictures, eight (6.5%) anastomotic leaks, and three (2.4%) intrahepatic strictures. Significant risk factors for anastomotic leaks were total operation time (increase 1.26‐fold) and early HAT (<30 days post‐LT; increase 5.87‐fold). Risk factor for primary anastomotic stricture was duct‐to‐duct choledochal anastomosis (increase 5.96‐fold when compared to biliary‐enteric anastomosis). Risk factors for intrahepatic strictures were donor age >48 yr (increase 1.09‐fold) and MELD score >30 (increase 1.2‐fold). To avoid morbidity from anastomotic BC in pediatric LT, the preferred biliary anastomosis appears to be biliary‐enteric. Operation time should be kept to a minimum, and HAT must by all means be prevented. Children with a high MELD score or receiving livers from older donors are at increased risk for intrahepatic strictures.
Pediatric split liver transplantation after Fontan procedure in left isomerism combined with biliary atresia: A case report
Authors: Youn Joong Kee , Lee Jeong‐Moo , Yi Nam‐Joon , Choi Young Rok , Suh Suk‐Won , You Tae , Lee Kwang‐Woong , Jung Chul‐Woo , Lee Ji‐won , Bae Eun‐Jung , Ko Jae Sung , Kim Woong‐Han , Park Kwi‐Won , Suh Kyung‐Suk 
Published: September 2014

AbstractLI is a subset of the heterotaxy syndrome and a rare birth defect that involves the heart and other organs. It can be combined with extracardiac abnormalities, especially BA. CHD can be associated with LI in up to 15% of cases, although it is rare in BA. Pediatric LT for a child with ESLD due to BA combined with LI and CHD is a challenging issue for a transplant surgeon. Herein, we report a successful split LT on a three‐yr‐old boy with LI who survived after a Fontan procedure due to single ventricle, but who suffered from HPS associated with BA.
The Key Role of Color Doppler Ultrasound in the Work‐up of Hemodialysis Vascular Access
Authors: Lomonte Carlo , Meola Mario , Petrucci Ilaria , Casucci Francesco , Basile Carlo 
Published: September 2014

AbstractVascular access (VA) is the lifeline for the hemodialysis patient and the native arterio‐venous fistula (AVF) is the first‐choice access. Among the different tests used in the VA domain, color Doppler ultrasound (CD‐US) plays a key role in the clinical work‐up. At the present time, three are the main fields of CD‐US application: (i) evaluation of forearm arteries and veins in surgical planning; (ii) testing of AVF maturation; (iii) VA complications. Specifically, during the AVF maturation, CD‐US allows to measure the diameter and flow volume in the brachial artery and calculate the peak systolic velocity (PSV) of the arterial axis, anastomosis and efferent vein, to detect critical stenosis. The borderline stenosis, revealed by the discrepancies between access flow rate and PSV, should be followed up with subsequent tests to detect progression of stenosis; the cases with significant changes in brachial flow should be referred to angiography. In conclusion, clinical monitoring remains the backbone of any VA program. CD‐US is of utmost importance in a patient‐centered VA evaluation, because it allows the appropriate management of all aspects of VA care. These are the main reasons why we strongly advocate the adoption of a VA surveillance program based on CD‐US.
The heart's ‘little brain’ controlling cardiac function in the rabbit
Authors: Brack Kieran E. 
Published: September 2014

New Findings
What is the topic of this review?
The topic of the review is the intrinsic cardiac nervous system in the rabbit.
What advances does it highlight?
The anatomy of rabbit intrinsic ganglia is similar to that of other species, including humans. Immunohistochemistry confirms the presence of cholinergic and adrenergic neurones, with a striking arrangement of neuronal nitric oxide synthase‐positive cell bodies. Activation of atrial ganglia produces effects on local and remote regions.
Heart disease is a primary cause of mortality in the developed world, and it is well recognized that neural mechanisms play an important role in many cardiac pathologies. The role of extrinsic autonomic nerves has traditionally attracted the most attention. However, there is a rich intrinsic innervation of the heart, including numerous cardiac ganglia (ganglionic plexuses), that has the potential to affect cardiac function independently as well as to influence the actions of the extrinsic nerves. To investigate this, an isolated, perfused, innervated rabbit Langendorff heart preparation was considered the best option. Although ganglionic plexuses have been well described for several species, there was no full description of the anatomy and histochemistry of rabbit hearts. To this end, rabbit intrinsic ganglia were located using acetylcholinesterase histology (n = 33 hearts). This revealed six generalized ganglionic regions, defined as a left neuronal complex above the left pulmonary vein, a right neuronal complex around the base of right cranial vein, three scattered in the dorsal right atrium and a region containing numerous ventricular ganglia located on the conus arteriosus. Using immunohistochemistry, neurons were found to contain choline acetyltransferase or tyrosine hydroxylase and/or neuronal nitric oxide synthase in differing amounts (choline acetyltransferase > tyrosine hydroxylase > neuronal nitric oxide synthase). The function of rabbit intrinsic ganglia was investigated using a bolus application of nicotine or electrical stimulation at each of the above sites whilst measuring heart rate and atrioventricular conduction. Nicotine applied to different ganglionic plexuses caused a bradycardia, a tachycardia or a mixture of the two, with the right atrial plexus producing the largest chronotropic responses. Electrical stimulation at these sites induced only a bradycardia. Atrioventricular conduction was modestly changed by nicotine, the main response being a prolongation. Electrical stimulation produced significant prolongation of atrioventricular conduction, particularly when the right neuronal complex was stimulated. These studies show that the intrinsic plexuses of the heart are important and could be crucial for understanding impairments of cardiac function. Additionally, they provide a strong basis from which to progress using the isolated, innervated rabbit heart preparation.
The role of AMPK in controlling metabolism and mitochondrial biogenesis during exercise
Authors: Marcinko Katarina , Steinberg Gregory R. 
Published: September 2014

New Findings
What is the topic of this review?
The topic of this review is the metabolic effects of AMP‐activated protein kinase (AMPK) on glucose and fatty acid (FA) uptake, FA oxidation and mitochondrial biogenesis in skeletal muscle at rest and during exercise/muscle contractions.
What advances does it highlight?
This review describes recent studies examining the molecular mechanisms by which AMPK regulates muscle metabolism. It specifically discusses the role of exercise on acetyl‐CoA carboxylase and malonyl‐CoA in the regulation of FA oxidation. It also discusses the role of AMPK in regulating glucose and FA uptake during exercise. Finally, the review describes the interaction between AMPK, peroxisome proliferator‐activated receptor γ co‐activator‐1α and sirtuin 1 in controlling mitochondrial biogenesis.
Insulin resistance is associated with defects in skeletal muscle fatty acid (FA) metabolism that contribute to the development of type 2 diabetes. Endurance exercise increases FA and glucose metabolism, muscle mitochondrial content and insulin sensitivity. In skeletal muscle, basal rates of FA oxidation are dependent on AMP‐activated protein kinase (AMPK) phosphorylation of acetyl‐CoA carboxylase 2, the rate‐limiting enzyme controlling the production of the metabolic intermediate malonyl‐CoA. Likewise, AMPK is essential for maintaining muscle mitochondrial content in untrained mice; effects that may be mediated through regulation of the peroxisome proliferator‐activated receptor γ co‐activator‐1α. However, the importance of AMPK in regulating glucose and FA uptake, FA oxidation and mitochondrial biogenesis during and following endurance exercise training is not fully understood. A better understanding of the mechanisms by which endurance exercise regulates substrate utilization and mitochondrial biogenesis may lead to improved therapeutic and preventative strategies for the treatment of insulin resistance and type 2 diabetes.
Triadin regulation of the ryanodine receptor complex
Authors: Marty Isabelle 
Published: September 2014

AbstractThe calcium release complex is the major player in excitation–contraction coupling, both in cardiac and skeletal muscle. The core of the complex is the ryanodine receptor, and triadin is a regulating protein. Nevertheless, the precise function of triadin is only partially understood. Besides its function in the anchoring of calsequestrin at the triad/dyad, our recent results allow us to propose hypotheses on new triadin scaffolding functions, based on the studies performed using different models, from triadin knockout mice to human patients, and expression in non‐muscle cells, taking into account the presence of multiple triadin isoforms.
Influence of Lysogeny of Tectiviruses GIL01 and GIL16 on Bacillus thuringiensis Growth, Biofilm Formation, and Swarming Motility
Authors: Gillis Annika , Mahillon Jacques 
Published: September 2014

ABSTRACT

Bacillus thuringiensis
is an entomopathogenic bacterium that has been used as an efficient biopesticide worldwide. Despite the fact that this bacterium is usually described as an insect pathogen, its life cycle in the environment is still largely unknown.
B. thuringiensis
belongs to the
Bacillus cereus
group of bacteria, which has been associated with many mobile genetic elements, such as species-specific temperate or virulent bacteriophages (phages). Temperate (lysogenic) phages are able to establish a long-term relationship with their host, providing, in some cases, novel ecological traits to the bacterial lysogens. Therefore, this work focuses on evaluating the potential influence of temperate tectiviruses GIL01 and GIL16 on the development of different life traits of
B. thuringiensis
. For this purpose, a
B. thuringiensis
serovar israelensis plasmid-cured (nonlysogenic) strain was used to establish bacterial lysogens for phages GIL01 and GIL16, and, subsequently, the following life traits were compared among the strains: kinetics of growth, metabolic profiles, antibiotics susceptibility, biofilm formation, swarming motility, and sporulation. The results revealed that GIL01 and GIL16 lysogeny has a significant influence on the bacterial growth, sporulation rate, biofilm formation, and swarming motility of
B. thuringiensis
. No changes in metabolic profiles or antibiotic susceptibilities were detected. These findings provide evidence that tectiviruses have a putative role in the
B. thuringiensis
life cycle as adapters of life traits with ecological advantages.