bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenol Decomposition by Pulsed‐Discharge Plasma Above a Water Surface in Oxygen and Argon Atmosphere
Authors: Shiota Haruki , Itabashi Hideyuki , Satoh Kohki , Itoh Hidenori 
Published: April 2013

AbstractBy‐products from phenol by the exposure of pulsed‐discharge plasma above a phenol aqueous solution are investigated by gas chromatography mass spectrometry, and the decomposition process of phenol is deduced. When Ar is used as a background gas, catechol, hydroquinone, and 4‐hydroxy‐2‐cyclohexene‐1‐one are produced, and no O3 is detected; therefore, active species such as OH, O, HO2, H2O2, which are produced from H2O in the discharge, can convert phenol into those by‐products. When O2 is used as a background gas, formic acid, maleic acid, succinic acid, and 4,6‐dihydroxy‐2,4‐hexadienoic acid are produced in addition to catechol and hydroquinone. O3 is produced in the discharge plasma, so that phenol is probably decomposed into 4,6‐dihydroxy‐2,4‐hexadienoic acid by 1,3‐dipolar addition reaction with O3, and then 4,6‐dihydroxy‐2,4‐hexadienoic acid can be decomposed into formic acid, maleic acid, and succinic acid by a 1,3‐dipolar addition reaction with O3. © 2013 Wiley Periodicals, Inc. Electr Eng Jpn, 184(1): 1–9, 2013; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.22419
Expanded Triphyrin Derived from a Carbacorrole Architecture
Authors: Pawlicki Miłosz , Kędzia Aneta , Szterenberg Ludmiła , Latos‐Grażyński Lechosław 
Published: April 2013

AbstractThe reactivity of a furan entrapped in a macrocycle leads to the formation of an [18]triphyrin(4.1.1) structure. Oxidative transformation of the final molecule gives two rigid lactams presenting structural factors of optically active compounds.
Internal Audit: A New Lens for Cost Management
Authors: Friedman Mark , Akaaboune Ouadie , Margolis Donna M. 
Published: April 2013

AbstractThe authors of this article see internal audit as a within‐firm tool that provides a new lens for cost management. Today, the role that the internal audit function plays in improving firm performance is being redefined. In part, this is because in today's fast‐paced economy, decisions are made quickly, and businesses need to draw on all of their resources to achieve competitive advantage. And, say the authors, the internal audit function is a natural fit for assisting in this newfound role—more than any other function in the organization. Internal audit will prove to be very useful as cost management takes an increasingly central role in strategy development. © 2013 Wiley Periodicals, Inc.
SEC Issues in 2013
Authors: Ciesielski Jack T. , Weirich Thomas R. 
Published: April 2013

AbstractThe American Institute of Certified Public Accountants held its annual “Current SEC & PCAOB Developments Conference” in Washington, D.C., in the first week of December 2012. A dominant theme was why accounting convergence has not happened yet. Attention was also paid to other international affairs, like the failure of firms to provide the Securities and Exchange Commission (SEC) with access to workpapers on audits of Chinese companies under investigation for accounting malfeasance. And on the very first day of the conference, the SEC announced the beginning of proceedings against the Big Four firms plus BDO for failure to cooperate. The authors of this article report in depth on this and other conference issues. © 2013 Wiley Periodicals, Inc.
Detection and typing of common human papillomaviruses among Jordanian patients
Authors: Al Bdour Suzan , Akkash Laith , Shehabi Asem A. 
Published: April 2013

AbstractThe epidemiology of human papillomaviruses (HPVs) genotype distribution of cutaneous warts in Jordanian patients were studied. A total of 200 samples were collected using skin swabs from patients with warts attending the dermatology clinic at the Jordan University Hospital over the period of June 2010 to October 2010. Another 100 control samples were taken from healthy Jordanian individuals with no current or previous history of warts. DNA extraction and sequencing was carried out using PCR with the FAP primer pair to detect HPV DNA, followed by multiple‐type‐specific (Multiplex) PCR combined with DNA sequencing. The prevalence of HPV among Jordanian patients tested with warts diagnosed clinically was 82% (157/192); of these 45% (87/192) were detected by FAP PCR method, and 37% (70/192) were detected by multiplex PCR method. Sequencing of the FAP positive samples shows that HPV 2 was associated with the highest prevalence (36%), followed by HPV 27 (28%) and HPV 57 (21%). A total of 6% of healthy persons were positive for HPV DNA. In conclusion, this study demonstrates that alpha HPV types (HPV 2, HPV 27, and HPV 57) are associated with the most prevalent cutaneous warts in Jordanian patients J. Med. Virol. 85: 1058–1062, 2013. © 2013 Wiley Periodicals, Inc.
TiO2‐g‐TEMPO. A Theoretical and Experimental Study
Authors: Nieto‐López I. , Sanchez‐Vazquez M. , Bonilla‐Cruz J. 
Published: April 2013

AbstractAn experimental and theoretical study to functionalize the surface of titanium dioxide nanoparticles (NPTiO2) with 2,2,6,6,tetramethylpiperidine‐N‐oxyl (TEMPO) in one step of synthesis using oxoammonium salts is presented. A general reaction mechanism to obtain functionalized nanoparticles (NPTiO2‐g‐TEMPO) is proposed, in which a peroxide bond (Ti‐O‐O‐N) between (Ti‐OH) and TEMPO is formed. Furthermore, Density Functional Theory (DFT) calculations in combination with the 6–31 + G(d) basis set, performed on the NPTiO2‐g‐TEMPO surface interaction, suggest the formation and stability of the new peroxide bond. Thus, the (O‐O) bond dissociation energy was calculated in 28.18 kcal/mol. Also, the maximum amount of TEMPO molecules bonded on the titanium surface was estimated by Molecular Mechanics (MM +) in 4 molecules/nm2. TGA and FTIR support our findings
Low‐density lipoprotein receptor‐related protein 1 variant interacts with saturated fatty acids in puerto ricans
Authors: Smith Caren E. , Tucker Katherine L. , Lee Yu‐Chi , Lai Chao‐Qiang , Parnell Laurence D. , Ordovás José M. 
Published: April 2013

AbstractObjective:Low‐density lipoprotein receptor‐related protein 1 (LRP1) is a multifunctional endocytic receptor that is highly expressed in adipocytes and the hypothalamus. Animal models and in vitro studies support a role for LRP1 in adipocyte metabolism and leptin signaling, but genetic polymorphisms have not been evaluated for obesity in people.Design and Methods:We examined whether dietary fats (eg., saturated, polyunsaturated) modulated the association of LRP1 rs1799986 with anthropometric traits. We studied a population‐based sample of Puerto Ricans (n = 920, aged 45–74 y) living in the Boston area.We examined whether dietary fats (eg., saturated, polyunsaturated) modulated the association of LRP1 rs1799986 with anthropometric traits. We studied a population‐based sample of Puerto Ricans (n = 920, aged 45–74 y) living in the Boston area.Results:In multivariable linear regression models, we dichotomized saturated fat intake and found significant interaction terms between total saturated fatty acids and LRP1 rs1799986 genotype for BMI (P=0.006) and hip (P = 0.002). High intake of saturated fat was associated with higher BMI (P = 0.001), waist (P = 0.008) and hip (P=0.003) in minor allele carriers (CT+TT) compared to CC participants. Further analysis of dichotomized individual saturated fatty acids revealed that interactions were strongest for two individual longer chain fatty acids. High intake of palmitic acid (C16:0; P = 0.0007) and high stearic acid intake (C18:0; P = 0.005) were associated with higher BMI in T carriers. Interactions were not detected for polyunsaturated fatty acids.Conclusions:Gene–diet interactions at the LRP1 locus support the hypothesis that susceptibility to weight gain based on saturated fatty acids is modified by genotype and possibly by chain length. These results may facilitate the development of a panel of genetic candidates for use in optimizing dietary recommendations for obesity management.
Tissue specificity in fasting glucose utilization in slightly obese diabetic patients submitted to bariatric surgery
Authors: Morbelli Silvia , Marini Cecilia , Adami Gian Franco , Kudomi Nobuyuki , Camerini Giovanni , Iozzo Patricia , Massollo Michela , Capitanio Selene , Bodrato Samanta , Verardi Maria Teresa , Papadia Francesco , Cordera Renzo , Knuuti Juhani , Scopinaro Nicola , Sambuceti Gianmario 
Published: April 2013

AbstractObjective:The present study was planned to investigate, by means of quantitative FDG‐PET, how bariatric surgery (BS) modifies the metabolic pattern of the whole body and different tissues in slightly obese patients with type 2 diabetes mellitus (T2DM).Design and Methods:Before, 1 and 4 months after BS, 21 consecutive slightly obese T2DM patients underwent blood sampling to estimate plasma levels of glucose, insulin, glycosylated hemoglobin. At the same time points, these patients underwent a dynamic 18F‐FDG PET study of thorax and upper abdomen in fasting state and after washout of T2DM therapy. Gjedde‐Patlak analysis was applied to estimate glucose uptake in the whole body and in different tissues (myocardium, skeletal back muscle, adipose tissue, and liver).Results:Surgical intervention quickly lowered levels of both insulin and glucose documenting an amelioration of glucose tolerance. Similarly, skeletal muscle and myocardial glucose uptake significantly increased soon after surgery (P < 0.001 and P < 0.01 at 1 month versus baseline, respectively) and remained substantially stable thereafter. By contrast, glucose uptake slightly decreased from its baseline values in the liver (P < 0.01 at 4 months) while no response could be documented over time in the adipose tissue.Conclusions:These findings document that BS‐induced modification of glucose homeostasis in slightly obese T2DM patients is mostly due to an increase in muscle glucose consumption. The surgically modified metabolic pattern of these patients might be of interest as a new model to investigate mechanism underlying insulin resistance.
Identification of sanguinarine metabolites in pig liver preparations by accurate mass measurements using electrospray ionization hybrid ion trap/time‐of‐flight mass spectrometry
Authors: Zhang Hua‐Hai , Wu Yong , Sun Zhi‐Liang , Liu Zhao‐Ying 
Published: April 2013

RATIONALESanguinarine (SA) is currently used in veterinary medicine for animal husbandry as a natural component of feed additive Sangrovit. To date, SA metabolism in food‐producing animals has not yet been reported. Therefore, the purpose of the present study was to investigate the metabolism of SA in pig liver microsomes and cytosol.METHODSThe SA incubations mixtures of microsomes and cytosol were processed by trichloroacetic acid (TCA) and acetonitrile. Then, the samples were analyzed using a sensitive and reliable method based on liquid chromatography combined with hybrid ion trap/time‐of‐flight mass spectrometry (LC‐IT/TOFMS). The structural elucidations of these metabolites were performed by comparing the changes in the accurate molecular masses and product ions generated from precursor ions with those of the parent drug.RESULTSSeven metabolites were identified in pig liver preparations. Dihydrosanguinarine (DHSA, m/z 334) was the main metabolite formed in liver microsomes and the only one in cytosol. One oxidative metabolite and two O‐demethylenated metabolites of SA (m/z 320) were found in the TCA‐treated microsomal samples. However, SA pseudobase and two additional O‐demethylenated metabolites of DHSA (m/z 322) were found only in the acetonitrile‐treated microsomal samples.CONCLUSIONSIt was demonstrated that different metabolites of SA were identified depending on the acidic or neural extraction conditions. A metabolic pathway of SA in pig was tentatively proposed based on these characterized metabolites and early reports. Copyright © 2013 John Wiley & Sons, Ltd.
Update in polycystic ovary syndrome: new criteria of diagnosis and treatment in Japan
Authors: Kubota Toshiro 
Published: April 2013

AbstractPolycystic ovary syndrome (PCOS) is the most frequent endocrine disorder in women of reproductive age. In 2006 the Japanese Society of Obstetrics and Gynecology (JSOG) proposed new, revised diagnostic criteria that in the future could also be valued internationally. Based on the new diagnostic criteria, the JSOG has also proposed the revised treatment criteria in 2008. In PCOS obese patients desiring children, weight loss and exercise is recommended. Nonobese patients, or those obese women who do not ovulate after lifestyle changes, are submitted to ovulation‐induction therapy with clomiphene citrate (CC). Obese CC‐resistant patients who have impaired glucose tolerance or insulin resistance are treated with a combination of metformin and CC. If these treatments options are unsuccessful, ovulation induction with exogenous gonadotropin therapy or laparoscopic ovarian drilling (LOD) is recommended. A low‐dose step‐up regimen is recommended with careful monitoring in order to reduce the risk of ovarian hyperstimulation syndrome (OHSS) and multiple pregnancies. Alternatively, with LOD high successful pregnancy rates of around 60 % are expected with a low risk of multiple pregnancies. If ovulation induction is unsuccessful, IVF‐ET treatment is indicated. In high OHSS‐risk patients, systematic embryo freezing and subsequent frozen embryo transfer cycles are recommended. In nonobese, anovulatory PCOS patients not desiring children, pharmacological treatments such as Holmström, Kaufmann regimens or low‐dose oral anticonceptives are used to induce regular withdrawal bleeding. These treatments are especially important for preventing endometrial hyperplasia and endometrial cancer. These new diagnostic and treatment criteria hopefully will contribute to an improved care of PCOS patients in Japan.
Effect of release rate and enantiomeric composition on response to pheromones of Megaplatypus mutatus (Chapuis) in poplar plantations of Argentina and Italy
Authors: Funes Hernán , Zerba Eduardo , Gonzalez-Audino Paola 
Published: April 2013

AbstractMegaplatypus mutatus (=Platypus sulcatus Chapuis) is an Ambrosia beetle native to South America, which was recently introduced in Italy and its presence there is causing severe damage to the local poplar plantations. The male M. mutatus pheromone is composed of (S)-(+)-6-methyl-5-hepten-2-ol [(+)-sulcatol], 6-methyl-5-hepten-2-one (sulcatone) and 3-pentanol. A series of field trials testing dose, blend and enantiomer composition performed in Argentina and Italy evaluated attraction and found that the optimal release rate of pheromone components as baits in cross vane baited traps (CIPEIN-CV) was 6, 6 and 30 mg day−1 of sulcatone, (+)-sulcatol and 3-pentanol, respectively. It was also determined that racemic sulcatol is as effective as the pure (+)-isomer for the purpose of beetle catch, due to the inert nature of the (−)-isomer allowing the usage of low cost racemic sulcatol instead of highly expensive (+)-sulcatol. The results of our work contribute to the development of pheromone-based local technologies with low environmental impact and low cost for control or monitoring of an important pest.
Single Center Experience of Cell‐Free and Concentrated Ascites Reinfusion Therapy in Malignancy Related Ascites
Authors: Ito Tetsuya , Hanafusa Norio , Fukui Mieko , Yamamoto Hiroko , Watanabe Yasuyuki , Noiri Eisei , Iwase Satoru , Miyagawa Kiyoshi , Fujita Toshiro , Nangaku Masaomi 
Published: April 2013

AbstractCell‐Free and Concentrated Ascites Reinfusion Therapy (CART) is expected to improve patients’ symptoms related to ascites. Use of a patient's own proteins in ascites might reduce the risk of infection. However, several reports have described that reinfusion of concentrated ascites might elevate body temperature. The aim of this study is to examine the safety and efficacy of the CART system performed exclusively on patients with malignancies. In this retrospective cohort observational study, we examined 81 CART processes performed on 24 patients with malignancies. Data were collected from medical records and records during processing of ascites. We investigated the effectiveness and adverse events during the procedures. The amount of ascites processed was 2.6 ± 1.4 L on average. The concentration ratio was 9.31 ± 5.45 on average. We found an increase in the urine volume after the procedure, which was significantly related to the amount of reinfused protein. The body temperature increased by 0.44°C. Systolic blood pressure decreased by 4 mm Hg after paracentesis, but no significant difference was found between the pressure before paracentesis and after reinfusion. In platelet counts, no significant change was observed. After all, no clinically significant adverse event was confirmed during CART procedures. Results show that CART can be performed safely even on patients with malignancy‐related ascites and that the procedure might improve diuresis.
Deletion of the major peroxiredoxin Tsa1 alters telomere length homeostasis
Authors: Lu Jian , Vallabhaneni Haritha , Yin Jinhu , Liu Yie 
Published: April 2013

SummaryReactive oxygen species (ROS) are proposed to play a major role in telomere length alterations during aging. The mechanisms by which ROS disrupt telomeres remain unclear. In Saccharomyces cerevisiae, telomere DNA consists of TG(1–3) repeats, which are maintained primarily by telomerase. Telomere length maintenance can be modulated by the expression level of telomerase subunits and telomerase activity. Additionally, telomerase‐mediated telomere repeat addition is negatively modulated by the levels of telomere‐bound Rap1‐Rif1‐Rif2 protein complex. Using a yeast strain defective in the major peroxiredoxin Tsa1 that is involved in ROS neutralization, we have investigated the effect of defective ROS detoxification on telomere DNA, telomerase, telomere‐binding proteins, and telomere length. Surprisingly, the tsa1 mutant does not show significant increase in steady‐state levels of oxidative DNA lesions at telomeres. The tsa1 mutant displays abnormal telomere lengthening, and reduction in oxidative exposure alleviates this phenotype. The telomere lengthening in the tsa1 cells was abolished by disruption of Est2, subtelomeric DNA, Rap1 C‐terminus, or Rif2, but not by Rif1 deletion. Although telomerase expression and activity are not altered, telomere‐bound Est2 is increased, while telomere‐bound Rap1 is reduced in the tsa1 mutant. We propose that defective ROS scavenging can interfere with pathways that are critical in controlling telomere length homeostasis.
Assessment and management of chronic orofacial pain associated with a disease in children: a multidisciplinary approach
Authors: Smaïl‐Faugeron Violaine , Courson Frédéric , Arrêto Charles‐Daniel 
Published: April 2013

AbstractTo summarize the diversity of assessment and management for chronic orofacial pain associated with a disease (COFPAD) in children. We performed a review of the literature up toMay 2012. Hetero‐evaluation and self‐assessment are used according to age of children. Strict management of the cause is not sufficient for children withCOFPADwithout a multidisciplinary approach combining pharmacotherapy, psychology and physiotherapy.ConclusionThe multidisciplinary approach is the key of management for children withCOFPAD.
Surgical treatment of buccal soft tissue recessions around single implants: 1‐year results from a prospective pilot study
Authors: Roccuzzo Mario , Gaudioso Luigi , Bunino Marco , Dalmasso Paola 
Published: April 2013

AbstractAimThe aim of this study was to evaluate the outcome of a soft tissue dehiscence coverage technique, at single non‐submerged implant sites, presenting shallow isolated buccal mucosal recession.Material and MethodsSixteen patients were included in this prospective study. A connective tissue graft (CTG) was harvested from the maxillary tuberosity. The donor soft tissue was de‐epithelialized and trimmed with a mucotome for an optimal adaptation to the collar of the implant.ResultsSurgery and healing proceeded with no complications and minimal post‐operative discomfort. One‐year follow‐up demonstrated clinical and esthetic improvements. Treatment resulted in 89.6 ± 13.1% mean coverage, and complete implant soft tissue coverage was achieved in nine of 16 cases, corresponding to a 56.3%. The VAS esthetic analysis showed a significant improvement from 3.6 ± 0.2 to 8.5 ± 0.3.ConclusionsThese positive preliminary results suggest that, by means of the surgical technique presented, buccal soft tissue dehiscences around single implants can be successfully treated. Additional Randomized controlled trials (RCTs) should be encouraged to assess the most effective variation to the technique in the various clinical situations and around implants of different designs.
Impact of complications of single tooth restorations on oral health‐related quality of life
Authors: Lam Walter Y. H. , McGrath Colman P. J. , Botelho Michael G. 
Published: April 2013

AbstractObjectiveTo compare oral health‐related quality of life (OHRQoL) among subjects who received implant‐supported crowns (ISC) and 2‐unit cantilevered resin‐bonded bridges (cRBB) in a bounded single tooth space (BSTS) after at least 5 years and to investigate factors associated with their OHRQoL.MethodsA case–control study among 78 subjects who received ISC or cRBB rehabilitation at a teaching hospital (39 ISCs and 39 cRBBs). OHRQoL was measured using the Oral Health Impact Profile (OHIP‐49) and compared between treatment modality. Variations in OHIP scores with respect to “minor complications” (repair of the original “survived” restorations) and “major complications” (replacement of “failed” restorations); and number of complications were determined in bivariate and multivariate analyses (negative binominal regression) controlling for socio‐demographic and clinical factors.ResultsOral Health Impact Profile scores were similar among those who received ISC and cRBB (P = 0.53). Among subjects with complicated restorations, those with major complications reported significantly higher OHIP scores (poorer OHRQoL) than those with minor complications (P = 0.02). Subjects who experienced multiple complications had significantly higher OHIP scores (poorer OHRQoL) than those with a single complication (P = 0.04). In regression analyses (which considered OHIP scores of those with complications), the nature of complications (P < 0.01), treatment modality (P = 0.04), and gender (P = 0.02) emerged as significant factors.ConclusionIn the rehabilitation of a BSTS patients, OHRQoL was similar irrespective of treatment modality (ISC or cRBB). Among those who experienced complications their OHRQoL was associated with the nature of complications, treatment modality and gender.