bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between the Risk of Suffering a First-Time Noncontact ACL Injury and Geometry of the Femoral Notch and ACL
Authors: Whitney Darryl C. , Sturnick Daniel R. , Vacek Pamela M. , DeSarno Mike J. , Gardner-Morse Mack , Tourville Timothy W. , Smith Helen C. , Slauterbeck James R. , Johnson Robert J. , Shultz Sandra J. , Hashemi Javad , Beynnon Bruce D. 
Published: May 2014

Background: The morphometric characteristics of the anterior cruciate ligament (ACL) and the femoral intercondylar notch within which it resides have been implicated as risk factors for injuries to this important stabilizer of the knee. Prior research has produced equivocal results with differing methodologies, and consequently, it is unclear how these characteristics affect the injury risk in male and female patients. Hypothesis: The morphometric characteristics of the ACL and femoral intercondylar notch are individually and independently associated with the risk of suffering a noncontact ACL injury, and these relationships are different in male and female patients. Study Design: Case-control study; Level of evidence, 3. Methods: Magnetic resonance imaging scans of the bilateral knees were obtained on 88 case-control pairs (27 male, 61 female) matched for age, sex, and participation on the same sports team. Patients had suffered a grade III, first-time, noncontact ACL tear. The femoral notch width at 4 locations, the thickness of the bony ridge at the anteromedial outlet of the femoral notch, the femoral notch volume, ACL volume, and ACL cross-sectional area were measured. Results: Multivariate analysis of combined data from male and female patients revealed that decreased ACL volume (odds ratio [OR], 0.829), decreased femoral notch width (OR, 0.700), and increased bony ridge thickness at the anteromedial outlet of the femoral notch (OR, 1.614) were significant independent predictors of an ACL injury. Separate analyses of male and female patients indicated that the femoral notch ridge may be more strongly associated with a risk in female patients, while ACL volume is more strongly associated with a risk in male patients. However, statistical analysis performed with an adjustment for body weight strengthened the association between ACL volume and the risk of injuries in female patients. Conclusion: Morphometric features of both the ACL and femoral notch combine to influence the risk of suffering a noncontact ACL injury. When included together in a multivariate model that adjusts for body weight, the effects of the morphometric measurements are similar in male and female patients. If body weight is not taken into consideration, ACL volume is not associated with a risk in female patients.
Which Rivastigmine Formula is Better for Heart in Elderly Patients With Alzheimer’s Disease
Authors: Isik Ahmet Turan , Soysal Pinar , Yay Adnan 
Published: May 2014

Objective: Rivastigmine is commonly used for the treatment of Alzheimer’s disease (AD). All cholinesterase inhibitors, including rivastigmine, may cause cardiac side effects. The aim of this study is to compare the electrocardiographic (ECG) and hypotensive effects of formulations of rivastigmine. Methods: Eighty-five newly diagnosed patients with AD who were treated with rivastigmine were retrospectively evaluated. The ECG records were reviewed at baseline and at administration of either 12 mg of oral rivastigmine or 10 cm2 transdermal rivastigmine. Results: When compared with the baseline, there were no changes in any of the ECG parameters in all of the patients ( P > .05). Moreover, when compared with the mean change from baseline for each treatment group, there were no changes, except heart rate ( P = .035). Conclusion: It was demonstrated that rivastigmine formulations were not associated with increased arrhythmogenic or hypotensive effects in elderly patients with AD and was not superior to each other.
Patient-reported outcomes in overactive bladder due to idiopathic detrusor overactivity: A correlation of two multi-domain questionnaires with a focus on quality of life and lifestyle goals
Authors: Irwin Paul P , Harris Maya 
Published: May 2014

Aims: The aims of this article are to correlate two multi-domain patient questionnaires for overactive bladder (OAB) and to assess their performance against quality-of-life measures. Methods: Patients with OAB symptoms due to idiopathic detrusor overactivity completed an Overactive Bladder Symptom Score (OABSS), an ICIQ-OAB questionnaire and a Likert quality of life (QoL) score before and six weeks following intravesical botulinum toxin treatment. They also listed lifestyle goals to which they aspired following treatment. Correlations between domains, total scores, QoL and goal achievement were calculated. Results: Fifty-seven patients returned 113 sets of questionnaires for analysis. A very close correlation was found between individual symptoms scores (Spearman r ranging from 0.93 for nocturia to 0.74 for urgency incontinence) and between the total scores of the two questionnaires ( r = 0.83). The sum of the OABSS+QoL scores also correlated strongly with total ICIQ-OAB scores ( r = 0.85). The correlation between total problem scores on the ICIQ-OAB and the Likert QoL was lower ( r = 0.689) but remained significant. The effect sizes (ES) were large (ranging from r = 0.6 to r = 1.0) and the standard response means (SRM) varied between 0.6 and 1.1, indicating a good correlation between the two questionnaires. Conclusions: Both questionnaires provide similar information in terms of symptom presence or absence and their impact on QoL. The addition of the QoL score to the standard OABSS did not add to its benefit.
How we evaluate and treat neutropenia in adults
Authors: Gibson Christopher , Berliner Nancy 
Published: May 2014

Abstract
Isolated neutropenia is a common clinical problem seen by primary care physicians and hematologists. The evaluation of neutropenia is dictated by the acuity of the clinical presentation and the duration, age, and clinical status of the patient. In this review, we provide a practical approach to the evaluation of the adult patient with neutropenia, with the major focus on the evaluation of neutropenia in the outpatient setting.
Paraneoplastic thrombocytosis: the secrets of tumor self-promotion
Authors: Lin Richard J. , Afshar-Kharghan Vahid , Schafer Andrew I. 
Published: May 2014

Abstract
Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet activation. Specific molecular pathways have been identified in which tumors can stimulate platelet production and activation; activated platelets can, in turn, promote tumor growth and metastasis. Taken together, these findings provide exciting new potential targets for therapeutic intervention.
Headache yesterday in Europe
Authors: Andrée Colette , Steiner Timothy J , Barré Jessica , Katsarava Zaza , Lainez Jose Miguel , Lampl Christian , Lantéri-Minet Michel , Rastenyte Daiva , Ruiz de la Torre Elena , Tassorelli Cristina , Stovner Lars Jacob 
Published: May 2014

Abstract

Background
Surveys enquiring about burden of headache over a prior period of time (eg, 3 months) are subject to recall bias. To eliminate this as far as possible, we focused on presence and impact of headache on the preceding day (“headache yesterday”).

Methods
Adults (18-65 years) were surveyed from the general populations of Germany, Italy, Lithuania, Luxembourg and the Netherlands, from a work-force population in Spain and from mostly non-headache patient populations of Austria, France and UK. A study of non-responders in some countries allowed detection of potential participation bias where initial participation rates were low.

Results
Participation rates varied between 11% and 59% (mean 27%). Non-responder studies suggested that, because of participation bias, headache prevalence might be overestimated in initial responders by up to 2% (absolute). Across all countries, 1,422 of 8,271 participants (15-17%, depending on correction for participation bias) had headache yesterday lasting on average for 6 hours. It was bad or very bad in 56% of cases and caused absence from work or school in 6%. Among those who worked despite headache, 20% reported productivity reduced by >50%. Social activities were lost by 24%. Women (21%) were more likely than men (12%) to have headache yesterday, but impact was similar in the two genders.

Conclusions
With recall biases avoided, our findings indicate that headache costs at least 0.7% of working capacity in Europe. This calculation takes into account that most of those who missed work could make up for this later, which, however, means that leisure and social activities are even more influenced by headache.
Anti-cancer activity of glucosamine through inhibition of N-linked glycosylation
Authors: Chesnokov Viktor , Gong Beata , Sun Chao , Itakura Keiichi 
Published: May 2014

Abstract

Background
We have reported that the glucosamine suppressed the proliferation of the human prostate carcinoma cell line DU145 through inhibition of STAT3 signaling. DU145 cells autonomously express IL-6 and the IL-6/STAT3 signaling is activated. IL-6 receptor subunits are subject to N-glycosylation, a posttranslational modification which is important for protein stability and function. We speculated that the inhibition of STAT3 phosphorylation by glucosamine might be a functional consequence of the reduced N-glycosylation of gp130.

Methods
The human prostate cancer cell lines DU145 and PC-3 and human melanoma cell line A2058 were used in this study. Glucosamine effects on N-glycosylation of glycoproteins were determined by Western blot analysis. IL-6 binding to DU145 cells was analyzed by flow cytometry. The cell proliferation suppression was investigated by colorimetric Janus green staining method.

Results
In DU145 cells glucosamine reduced the N-glycosylation of gp130, decreased IL-6 binding to cells and impaired the phosphorylation of JAK2, SHP2 and STAT3. Glucosamine acts in a very similar manner to tunicamycin, an inhibitor of protein N-glycosylation. Glucosamine-mediated inhibition of N-glycosylation was neither protein- nor cell-specific. Sensitivity of DU145, A2058 and PC-3 cells to glucosamine-induced inhibition of N-glycosylation were well correlated to glucosamine cytotoxicity in these cells.

Conclusion
Our results suggested that the glucosamine-induced global inhibition of protein N-glycosylation might be the basic mechanism underlying its multiple biochemical and cellular effects.
Effects of the alkylamine functionalization of graphene oxide on the properties of polystyrene nanocomposites
Authors: Jang Jinhee , Pham Viet Hung , Rajagopalan Balasubramaniyan , Hur Seung Hyun , Chung Jin Suk 
Published: May 2014

AbstractAlkylamine-functionalized graphene oxides (FGOs) have superior dispersibility in low-polar solvents and, as a result, they interact with low-polar polymers such as polystyrene. In this work, the functionalization of graphene oxide using three types of alkylamines, octylamine (OA), dodecylamine (DDA), and hexadecylamine (HDA), was performed, and nanocomposites of polystyrene (PS) and FGOs were prepared via solution blending. Different dispersions of FGOs over PS were obtained for the three alkylamines, and the properties of the PS composites were influenced by the length of the alkylamine. A better thermal stability was observed with a longer chain length of the alkylamine. On the other hand, functionalization with the shortest chain length alkylamine resulted in the highest increase in the storage modulus (3,640 MPa, 140%) at a 10 wt.% loading of FGO.
Erythritol production on wheat straw using Trichoderma reesei
Authors: Jovanović Birgit , Mach Robert L , Mach-Aigner Astrid R 
Published: May 2014

Abstract
We overexpressed the err1 gene in the Trichoderma reesei wild-type and in the cellulase hyperproducing, carbon catabolite derepressed strain Rut-C30 in order to investigate the possibility of producing erythritol with T. reesei. Two different promoters were used for err1 overexpression in both strains, a constitutive (the native pyruvat kinase (pki) promoter) and an inducible one (the native β-xylosidase (bxl1) promoter). The derived recombinant strains were precharacterized by analysis of err1 transcript formation on D-xylose and xylan. Based on this, one strain of each type was chosen for further investigation for erythritol production in shake flasks and in bioreactor experiments. For the latter, we used wheat straw pretreated by an alkaline organosolve process as lignocellulosic substrate. Shake flask experiments on D-xylose showed increased erythritol formation for both, the wild-type and the Rut-C30 overexpression strain compared to their respective parental strain. Bioreactor cultivations on wheat straw did not increase erythritol formation in the wild-type overexpression strain. However, err1 overexpression in Rut-C30 led to a clearly higher erythritol formation on wheat straw.
Integrative gene transfer in the truffle Tuber borchii by Agrobacterium tumefaciens-mediated transformation
Authors: Brenna Andrea , Montanini Barbara , Muggiano Eleonora , Proietto Marco , Filetici Patrizia , Ottonello Simone , Ballario Paola 
Published: May 2014

Abstract

Agrobacterium tumefaciens-mediated transformation is a powerful tool for reverse genetics and functional genomic analysis in a wide variety of plants and fungi. Tuber spp. are ecologically important and gastronomically prized fungi (“truffles”) with a cryptic life cycle, a subterranean habitat and a symbiotic, but also facultative saprophytic lifestyle. The genome of a representative member of this group of fungi has recently been sequenced. However, because of their poor genetic tractability, including transformation, truffles have so far eluded in-depth functional genomic investigations. Here we report that A. tumefaciens can infect Tuber borchii mycelia, thereby conveying its transfer DNA with the production of stably integrated transformants. We constructed two new binary plasmids (pABr1 and pABr3) and tested them as improved transformation vectors using the green fluorescent protein as reporter gene and hygromycin phosphotransferase as selection marker. Transformants were stable for at least 12 months of in vitro culture propagation and, as revealed by TAIL- PCR analysis, integration sites appear to be heterogeneous, with a preference for repeat element-containing genome sites.
At the Bench:Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer
Authors: Hardbower Dana M , Peek Richard M , Wilson Keith T 
Published: May 2014

AbstractHelicobacter pylori infection is the strongest known risk factor for the development of gastric cancer. Given that ∼50% of the global population is infected with this pathogen, there is great impetus to elucidate underlying causes that mediate progression from infection to cancer. Recent evidence suggests that H. pylori-induced chronic inflammation and oxidative stress create an environment conducive to DNA damage and tissue injury. DNA damage leads to genetic instability and eventually, neoplastic transformation. Pathogen-encoded virulence factors induce a robust but futile immune response and alter host pathways that lower the threshold for carcinogenesis, including DNA damage repair, polyamine synthesis and catabolism, antioxidant responses, and cytokine production. Collectively, such dysregulation creates a protumorigenic microenvironment within the stomach. This review seeks to address each of these aspects of H. pylori infection and to call attention to areas of particular interest within this field of research. This review also seeks to prioritize areas of translational research related to H. pylori-induced gastric cancer based on insights garnered from basic research in this field. See related review by Dalal and Moss, At the Bedside: H. pylori, dysregulated host responses, DNA damage, and gastric cancer.
Halogen-Bond Interactions Enhanced by Charge-Assisted Hydrogen Bonds: An Ab Initio Study
Authors: Esrafili Mehdi D , Mohammadian-Sabet Fariba 
Published: May 2014

Abstract
The NH4+···NCX···NCY (X = F, Cl, and Br; Y = H, F, and OH) complexes are theoretically investigated to find ways to enhance the halogen-bond interaction. Cooperative effects are observed when a charge-assisted hydrogen bond (CAHB) and halogen bond coexist in the same complex. These effects are studied in terms of equilibrium geometry, interaction energy, charge-transfer properties, and 14N nuclear quadrupole coupling constant of the complexes at the MP2/aug-cc-pVTZ level. In all triads studied, a favorable cooperativity is found with values that range between −1.44 and −4.04 kcal mol−1. However, the increased percentage of the interaction energy depends on the interaction strength. To investigate the role of different energy terms in cooperativity between hydrogen and halogen bonds, the scheme of decomposition of the interaction energy is applied. The electrostatic interaction is found to be a dominant factor in enhancing both types of interactions.
Effect of chromosome substitution on intrinsic exercise capacity in mice
Authors: Courtney Sean M. , Massett Michael P. 
Published: May 2014

Previous research identified a locus on Chromosome 14 as an important regulator of endurance exercise capacity in mice. The aim of this study was to investigate the effect of chromosome substitution on intrinsic exercise capacity and identify quantitative trait loci (QTL) associated with exercise capacity in mice. Mice from a chromosome substitution strain (CSS) derived from A/J and C57Bl/6J (B6), denoted as B6.A14, were used to assess the contribution of Chromosome 14 to intrinsic exercise capacity. All mice performed a graded exercise test to exhaustion to determine exercise capacity expressed as time (min) or work (kg·m). Exercise time and work were significantly greater in B6 mice than B6.A14 and A/J mice, indicating the presence of a QTL on Chromosome 14 for exercise capacity. To localize exercise-related QTL, 155 B6.A14 x B6 F2mice were generated for linkage analysis. Suggestive QTL for exercise time (57 cM, 1.75 LOD) and work (57 cM, 2.08 LOD) were identified in the entire B6.A14 x B6 F2cohort. To identify putative sex-specific QTL, male and female F2cohorts were analyzed separately. In males, a significant QTL for exercise time (55 cM, 2.28 LOD) and a suggestive QTL for work (55 cM, 2.19 LOD) were identified. In the female cohort, no QTL was identified for time, but a suggestive QTL for work was located at 16 cM (1.8 LOD). These data suggest that one or more QTL on Chromosome 14 regulate exercise capacity. The putative sex-specific QTL further suggest that the genetic architecture underlying exercise capacity is different in males and females. Overall, the results of this study support the use of CSS as a model for the genetic analysis of exercise capacity. Future studies should incorporate the full panel of CSS using male and female mice to dissect the genetic basis for differences in exercise capacity.
MATHEMATICAL MODELING OF SURFACE INDUCTION HEATING
Authors: Smalcerz Albert , Wieczorek Jakub , Slezok Maria 
Published: May 2014

The paper presents possibilities of controlling temperature field distribution in induction heated charge. The change of the distribution was obtained with use of sequential two-frequency heating. The study was conducted as multi-variant computer simulations of strongly coupled to each other field: the electromagnetic and the temperature fields. For the analysis, the professional calculation package using the finite element method Flux 3D was used. The problem of obtaining an appropriate temperature distribution in a heated charge of, a complex shape is very important in many practical applications. A typical example is a quenching of gears. For such applications, it is required to obtain a surface and in desired depth, uniform temperature distribution on the tooth face and top land and on the bottom land of the gear. The obtained temperature should have proper distribution and value. Achieving such a defined distribution is very difficult. During the study over a dozen different calculation variants were examined.
Decentralized Procurement in Light of Strategic Inventories
Authors: Arya Anil , Frimor Hans , Mittendorf Brian 
Published: May 2014

The centralization versus decentralization choice is perhaps the quintessential organizational structure decision. In the operations realm, this choice is particularly critical when it comes to the procurement function. Why firms may opt to decentralize procurement has been often studied and confirmed to be a multifaceted choice. This paper complements existing studies by detailing the trade-offs in the centralization versus decentralization decision in light of firms' strategic use of inventories to influence supplier pricing. In particular, we demonstrate that a firm's decision to cede procurement choices to its individual divisions can help moderate inventory levels and provide a natural salve on supply chain frictions. This paper was accepted by Serguei Netessine, operations management.
Parental Adaptation to Out-of-Home Placement of a Child With Severe or Profound Developmental Disabilities
Authors: Jackson Jeffrey B. , Roper Susanne Olsen 
Published: May 2014

Abstract
Utilizing grounded theory qualitative research methods, a model was developed for describing parental adaptation after voluntary placement of a child with severe or profound developmental disabilities in out-of-home care. Interviews of parents from 20 families were analyzed. Parents' cognitive appraisals of placement outcomes were classified as either inducing emotional stress (i.e., guilt, sadness, fear and worry, anger and frustration, and uncertainty) or relief. Parental appraisals of responses to placement by children, extended family, and friends were identified as factors affecting the parents' adaptation to placement. The primary coping methods used by parents to decrease emotional stress and increase relief consisted of reappraisals regarding the necessity of placement, involvement in the child's life, psychotherapy, and the passage of time.
Epidemiology of Epilepsy in Older Adults With an Intellectual Disability in Ireland: Associations and Service Implications
Authors: McCarron Mary , O'Dwyer Marie , Burke Eilish , McGlinchey Eimear , McCallion Philip 
Published: May 2014

AbstractThere are limited studies on the prevalence of epilepsy and co-morbid conditions in older adults with an ID. To begin to address this prevalence of epilepsy was estimated for participants in the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing. Associations with demographic variables and co morbid health conditions were examined. It was found that prevalence was high (30.7%); but declined as people aged. Those with epilepsy were less likely to live with family, independently or in community settings, rates of refractory epilepsy were high and, despite medication over half of those with epilepsy still reported experiencing seizures. Given these findings, people with ID and their careers have considerable needs for information about epilepsy management, and for support from specialist ID and epilepsy services.