bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of CSR on enterprise value: the case of China’s real estate industry
Authors: Kong Xinran , Wang Wei 
Published: June 2024

PurposeResearch on corporate social responsibility (CSR) within the real estate sector is limited, and the precise workings of its impact are still unclear. Under the premise that real estate enterprises face environmental uncertainty in China, this study explored the impact of CSR on real estate enterprise value.Design/methodology/approachTo investigate the impact of CSR on enterprise value, we studied 111 real estate enterprises with A-shares listed on Shanghai and Shenzhen stock exchanges from 2010 to 2020, and performed empirical tests to determine the moderating effect of environmental uncertainty on this relationship.Findings(1) The fulfillment of corporate social responsibility (CSR) significantly influences the value of real estate enterprises. A sub-dimensional analysis reveals that fulfilling stakeholder and social welfare responsibilities within CSR positively impacts enterprise value, whereas environmental responsibility does not exert a notable effect. (2) The uncertainty associated with environmental changes profoundly affects the relationship between CSR and the value of real estate enterprises. More precisely, as environmental uncertainty increases, it amplifies the beneficial impact of CSR on enterprise value.Practical implicationsThese findings are valuable for real estate enterprises as they navigate the transition towards sustainable development, and they also provide insight for the government in formulating policies aimed at regulating the real estate sector.Originality/valueThis study complements the existing discussion and research on corporate social responsibility (CSR) and enterprise value in the real estate industry, while elucidating the underlying mechanism of how environmental uncertainty mediates the relationship between the two.
Unleashing innovation through employee voice behavior in the hotel industry: the impact of ambidextrous leadership on innovative work behavior
Authors: Ajmal Muhammad , Sareet Zarafshan , Islam Azmat 
Published: June 2024

PurposeIn today's dynamic and competitive business environment, organizations strive to foster innovation as a key driver of success. To achieve this, leaders play a critical role in promoting innovative work behavior among employees. This study is based on finding the effect of ambidextrous leadership on innovative work behavior with employee voice behavior as a mediator and employee moral identity as a moderator.Design/methodology/approachThis study is conducted on Pakistan's hotel and restaurant industry. Drawing upon a sample of 410 valid responses from employees from various hotels, data is collected using self-report questionnaires.FindingsThe study revealed that ambidextrous leadership is positively related to innovative work behavior, and employee voice behavior mediated their relationship very well. However, ambidextrous leadership generates more positive and creative outcomes for the organization if it accompanies employee voice. Moreover, employees with a stronger moral identity are more likely to engage in voice behavior when they perceive ambidextrous leadership practices.Practical implicationsIn Pakistan's hotel industry, developing leadership programs that focus on ambidextrous leadership, encouraging employee voice, and aligning with employees' moral values are key to fostering innovation. Organizations should cultivate a culture of openness, trust, and recognition, alongside implementing systems that reward innovative contributions. It's crucial to provide opportunities for skill development, decision-making participation, and a sense of ownership among employees. Moreover, providing necessary resources and supporting a culture that embraces experimentation and learning from failures are fundamental for sustained innovation.Originality/valueBy adopting ambidextrous leadership practices, leaders can stimulate employee voice behavior, which, in turn, contributes to the development of innovative work behavior. Furthermore, understanding the importance of employee moral identity can help leaders tailor their leadership approaches to create an ethical work environment that promotes employee engagement and innovation.
Business expansion strategy of two-sided platform considering technology R & D effect and congestion effect
Authors: Yuan Junxia , Liu Renhuai , Zou Yuanyang 
Published: June 2024

PurposeA new model for two-sided platforms is presented, incorporating both the original business and an expanded (new) business. Previous studies have neglected the impact of technology R & D on the new business aspect of two-sided platforms. This study addresses this gap by examining the technology R & D effect on the new business while also considering the congestion effect on the original business. It investigates the optimal pricing and user scales for both the original and new businesses. Additionally, the profits of the original business, the new business, and the overall two-sided platform are analyzed.Design/methodology/approachPrevious studies have overlooked the technology R & D effect on the new business aspect of two-sided platforms. Therefore, this study focuses on examining the technology R & D effect on the new business. Additionally, the congestion effect on the original business is considered. To determine the optimal prices for both sides of the original and new businesses, a game sequence model is introduced.FindingsThe optimal price on the service buyers (defined b side) of new business increases only with regard to technology R & D effect on b side of new business increasing. The optimal price on b side of new business is equal to half of the b-side R & D effect. The optimal profit of original business decreases with regard to the technology R & D effect of new business and cross-market network effect on the services provider (defined s side) between original business and new business increasing, respectively. To gain optimal profit of two-sided platform, the two-sided platform adopts some strategies to improve the congestion.Originality/valueA new two-sided platform model is stated, in which the technology R & D effect is embraced. The expanded business scenario of two-sided platform is considered, that is, the two-sided platform has one business firstly and a new business is developed or improved of two-sided platform. To solve the prices strategy of original business and new business, a game sequence of the original business and new business is presented.
Bibliometric analysis on usage of Industry 4.0 technologies in healthcare
Authors: Khanuja Anurodhsingh , Sreedharan Rajan , Sharma Neha 
Published: June 2024

PurposeIndustrial Revolution 4.0 prompts organizations to adopt emerging technologies, and the healthcare industry is no different from them. Further, it is important to adopt new edge technologies to improve services and the well-being of patients. This research synthesizes the work most influenced by this technology and the trends and usage of Industry 4.0 technologies in the healthcare sector.Design/methodology/approachThe study has used the Scopus and Web of Science databases to retrieve articles published in healthcare and Industry 4.0 for bibliometric analysis. Specifically, Bibliometrix (R-package) and VOSviewer were used to analyze data related to authors, sources, keywords and content analysis.FindingsThe study found increased research trends in Industry 4.0 and healthcare in recent years. The USA, India and China are top contributors in this field, showing research progress in developed and developing economies. Dwivedi Y and Kumar A. were top researchers in the field. The finding also reveals that predictive analytics, deep technology and sustainable development are emerging areas for healthcare where Industry 4.0 can play a crucial role.Practical implicationsUsing Industry 4.0 technologies can help the company improve its services, operational efficiency and patient care.Originality/valueThe study explored the trends in the healthcare sector for using Industry 4.0 technologies through bibliometric analysis.
Accelerated idioventricular rhythm as a manifestation of chronic renocardiac syndrome: A case report
Authors: Kotzadamis Dimitrios , Gkroumtsia Evangelia , Papadopoulos Christodoulos , Vassilikos Vassilios 
Published: June 2024

AbstractIn this case report, we describe a patient who presented with chronic symptoms and signs of uremia and persistent accelerated idioventricular rhythm (AIVR) on electrocardiogram. Findings from blood tests, echocardiography, renal ultrasound, and renal scan were suggestive of heart failure with reduced ejection fraction and chronic kidney disease, and attendance of daily hemodialysis sessions led to the restoration of sinus rhythm. Typically, AIVR has a favorable prognosis and, if necessary, medical intervention focuses on addressing the underlying responsible causes. Accumulation of uremic toxins has the potential to trigger the formation of AIVR and clearance of small solutes through conventional hemodialysis may contribute to sinus rhythm restoration.
Impact of modifications to antidementia drug reimbursement in France: Analysis of the FRA‐DEM cohort
Authors: Couret Anaïs , Gardette Virginie , Renoux Axel , Lapeyre‐Mestre Maryse 
Published: June 2024

AimsAlzheimer's disease and related diseases (ADRD) is a progressive and inexorable disease. In France, acetylcholinesterase inhibitors and memantine were reimbursed for subjects with ADRD, until 2 modifications of their reimbursement rate (2012, 2018). We aimed to study the consequences of these measures on ADRD subjects' healthcare use.MethodsWe analysed data from the FRA‐DEM cohort, including subjects with presumed incident ADRD identified since 2011 in the French health insurance system. We studied the healthcare use of subjects identified with incident ADRD in 2011, 2013, 2015, 2017 and 2019, notably the annual number of defined daily doses of various psychotropic groups. We performed 2 multivariate multinomial logistic regressions with the subcohort year as the dependent variable.ResultsIn total, 165 120 subjects were included. A progressive decrease in exposure to antidementia drugs was observed between 2011 and 2019. Consultations with private neurologists or psychiatrists, and exposure to risperidone, antidepressants and benzodiazepines increased in the 2019 subcohort, following the 2018 reimbursement withdrawal. Meanwhile, the use of nursing/allied healthcare and emergency care increased over the subcohort years, whereas we observed a decrease in general practitioner consultations.ConclusionThese results suggest increases in private neurologist or psychiatrist consultations and exposure to recommended drugs after the reimbursement withdrawal, contrary to the fears expressed. However, antidementia drug exposure decreased long before the reimbursement modifications, probably due to the growing evidence of the modest effect of these drugs, and exposure to benzodiazepines increased after the reimbursement withdrawal.
Combined effect of CYP2C19 and CYP2D6 genotypes on escitalopram serum concentration and its metabolic ratio in a European patient population
Authors: Faraj Pari , Haslemo Tore , Tran Jenny Phung , Stingl Julia , Molden Espen , Hole Kristine 
Published: June 2024

AimsThe aim of the present study was to investigate the impact of CYP2D6 genotype on exposure and metabolism of escitalopram in patients stratified by CYP2C19 genotype in a large real‐world population.MethodsPatients were included from a therapeutic drug monitoring service if they had measured serum concentration of escitalopram and the metabolite, N‐desmethyl escitalopram, and performed CYP2C19 and CYP2D6 genotyping. Patients were divided into 16 combined genotype‐predicted phenotype subgroups (poor [PM], intermediate [IM], normal [NM] and ultrarapid metabolizers [UM]) of CYP2C19/CYP2D6. The concentration‐to‐dose (CD) ratio and metabolite‐to‐parent ratio (metabolic ratio) of escitalopram were compared across subgroups using the Kruskal–Wallis test followed by Dunn's test with CYP2D6 NMs as the reference group.ResultsA total of 5067 patients were included in the study. A stepwise increase in escitalopram CD ratio by decreasing CYP2D6 activity was observed in all CYP2C19 subgroups, except for in CYP2C19 UMs. The percentage differences in escitalopram CD ratio between CYP2D6 PMs and NMs were 24% in CYP2C19 NMs (P < .001), 28% in CYP2C19 IMs (P < .001) and 31% in CYP2C19 PMs (P = .04). As for the CD ratio, CYP2D6 genotype effect on metabolic ratio increased stepwise by decreasing CYP2C19 metabolism.ConclusionsCYP2D6 genotype is of significant importance for the individual variation in escitalopram pharmacokinetics. The most relevant increase in escitalopram concentration is seen in individuals with decreased and/or absent CYP2C19 activity. By combining CYP2C19 and CYP2D6 genotypes, the optimal dose for patients may be predicted with greater precision than for CYP2C19 genotype alone.
Antiperspirant‐related zirconium and aluminum‐containing granulomas; histopathology and in situ chemical analysis
Authors: Sanford Jeffrey A. , Candelaria‐Santiago Roberto , Forte Dominic M. , Curcio Christian A. , Allbritton Jill I. , Strausborger Stacy L. , Lewin‐Smith Michael R. 
Published: June 2024

AbstractThe potential adverse health effects of antiperspirant use are of interest to patients, primary care providers, dermatologists, and pathologists. In rare instances, antiperspirants containing aluminum–zirconium complexes have been associated with granulomatous dermatoses despite being deemed non‐sensitizing in experiments. In this case study, we present a detailed examination of an axillary granuloma in a 28‐year‐old female who had been using an aluminum–zirconium‐based antiperspirant for several years and presented with a left axillary nodule that was excised and analyzed using scanning electron microscopy with energy‐dispersive x‐ray analysis (SEM/EDXA). Histopathological examination revealed a foreign body‐type reaction with amphophilic granular material within giant cells that corresponded to collocated zirconium and aluminum on SEM/EDXA elemental maps. Our case adds to the limited reports of axillary granulomas related to aluminum–zirconium complexes. It illustrates the histopathological appearance and in situ distribution of the aluminum–zirconium complexes, supporting the formation of foreign body‐type granulomas. Additionally, our case study illustrates the potential role of these compounds in such reactions and aims to increase awareness among pathologists and clinicians.
Sexual dimorphism in head size in wild burying beetles
Authors: Smith Jack M. L. , Catherall‐Ostler Andrew M. , Mashoodh Rahia , Kilner Rebecca M. 
Published: June 2024

Abstract
The burying beetle (Nicrophorus vespilloides) is thought to be predominantly sexually monomorphic. Males carry an additional abdominal segment and produce pheromones, but otherwise the sexes are alike.
Both sexes bear bright orange bands on their black elytra, which probably function as part of a warning display rather than in mate choice. In wild populations, the sexes do not differ in mean body size, nor in its variation.
Here we describe a form of sexual size dimorphism in wild populations that has previously been overlooked. We show that males have wider heads than females, for any given pronotum width (body size), and that the scaling relationship between head width and pronotum width is hyperallometric in males, but isometric in females. We also show how absolute head width, as well as the extent of sexual dimorphism in head width, differs among seven wild populations inhabiting different woodlands that are within c.10 km of each other.
We suggest that head size dimorphism is functionally related to bite force. We hypothesise that dimorphism could be due to divergent selection arising from task specialisation during biparental care, as the duties of care favoured by males are likely to require a greater bite force.
Peatland carbon chemistry, amino acids and protein preservation in biogeochemically distinct ecohydrologic layers
Authors: Yusuf Anne Yalien , Silvester Ewen , Brkljaca Robert , Birnbaum Christina , Chapman James , Grover Samantha 
Published: June 2024

AbstractPeatlands play a significant role in global carbon and nitrogen cycles due to their carbon storage capabilities. However, there are key knowledge gaps in our understanding of how peatland hydrology influences the biogeochemical properties that drive peatland functioning and health. This study examines peatland hydrology and biogeochemical dynamics by exploring the variations in carbon chemistry, total amino acid (‘protein’) content and amino acid composition in the ecohydrologic layers: acrotelm, mesotelm and catotelm. The dynamic movement of the water table recorded half‐hourly over 4 years was used to assist in identifying the boundaries between these layers. Peat amino acids were measured using liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Carbon chemistry was analysed by solid state Cross Polarization Magic Angle Spinning (CPMAS) 13C Nuclear Magnetic Resonance (NMR) spectroscopy, with the alkyl:O‐alkyl ratio used to quantify the extent of decomposition. Our result revealed a strong positive correlation between the extent of decomposition and total protein content, indicating selective preservation of proteinaceous materials during peat decomposition. Each ecohydrologic layer displayed a distinct amino acid composition and carbon functional group composition. The acrotelm was relatively enriched in seven amino acids and two carbon functional groups. The mesotelm was relatively enriched in four amino acids, while the catotelm was relatively enriched in three amino acids and four carbon functional groups. The variations in amino acid composition reflect differences in microbial function and efficiency, while variations in carbon functional groups provide insights into long‐term carbon sequestration in peatland. Collectively, these results provide more insights into nutrient cycling and changes in organic matter composition during peat decomposition. These findings demonstrate that peatland biogeochemistry is closely linked to ecohydrology and suggest that changes to water table dynamics could affect the ability of peatlands to sequester and store carbon in the future.
Effects of urbanization and deforestation on flooding: Case study of Cap‐Haïtien City, Haiti
Authors: Jean Louis Madoche , Crosato Alessandra , Mosselman Erik , Maskey Shreedhar 
Published: June 2024

AbstractCap‐Haïtien, the second largest city in Haiti, is highly vulnerable to earthquakes, landslides, and flooding. The rapid pace of urbanization and deforestation has exacerbated the risk of flooding, resulting in disasters in November 2012, 2016, and 2022. This study aims to assess the impact of urbanization and deforestation on river flooding in Cap‐Haïtien by applying the hydrological model Soil Water Assessment Tool (SWAT) and the hydrodynamic model Sobek‐Rural. We examined the current situation and a scenario of future urbanization and deforestation. Urbanization and deforestation are found to play a pivotal role in the production and deposition of sediment along the lower Haut‐du‐Cap River reaches. The existing hydraulic capacity of the river and its drainage system cannot handle the estimated peak flows. The mountain ravines west of the city are found to be the primary source of sediment‐laden flash floods. We recommend retention basins, drainage extensions, and pragmatic public policies to mitigate flood risk. Comprehensive strategies are needed to address the detrimental effects of urbanization and deforestation on flooding in Cap‐Haïtien and similar regions where a lack of water governance has worsened the flooding alongside urbanization and deforestation. We generalize our experiences from Cap‐Haïtien into a broader framework for data‐scarce areas.
Treatment patterns and oncological outcomes of older adults with metastatic prostate cancer in real‐world setting
Authors: Wenzel Mike , Hoeh Benedikt , Wagner Nele , Koll Florestan , Siech Carolin , Humke Clara , Steuber Thomas , Graefen Markus , Tilki Derya , Kluth Luis , Traumann Miriam , Banek Séverine , Chun Felix K. H. , Mandel Philipp 
Published: June 2024

AbstractBackgroundThe landscape of systemic therapies for metastatic hormone‐sensitive (mHSPC) and castration resistant prostate cancer (mCRPC) extensively improved within the last decades resulting in a significantly prolonged overall survival. However, subgroup analyses of phase III trials suggest potentially different overall survival outcomes for older adults.MethodsWe relied on our institutional metastatic prostate cancer database to identify mHSPC and subsequently mCRPC patients. Older adults were stratified according to age groups 70–74 versus ≥75–79 versus ≥80 years at metastatic occurrence. Subsequently, uni‐ and multivariable time to mCRPC and overall survival analyses were performed.ResultsOf 494 older adults, 217 (44%) were 70–74 versus 180 (36%) 75–79 versus 97 (20%) ≥80 years old. Rates of local prostate cancer treatment differed significantly between all three groups (p < 0.01). Regarding mHSPC treatment, androgen receptor signaling inhibitors (ARSI) were administered in 30–39% of patients and docetaxel with 9% in age group 70–74 years and 6% and 3% in age groups 75–79 years and ≥80 years. Regarding mCRPC treatment, significant differences between treatment proportions were observed (p < 0.01). Most common treatment was ARSI for all three groups. Conversely, chemotherapy was more frequently administered in patients aged 70–74 (16%), relative to 4% and 3% in 75‐79 year and ≥80 year aged patients. In univariable and multivariable time to mCRPC analyses, overall survival in mHSPC and OS in mCRPC analyses, no significant differences between all three age groups were observed (all p ≥ 0.3).ConclusionsTreatment patterns differ significantly between older adults with metastatic prostate cancer. However, these differences may not result in differences of overall life expectancy.
A predictive study of genes related to lactic acid metabolism in cervical carcinoma
Authors: Zou Kehan , Ou Jie 
Published: June 2024

AbstractObjectivesLactic acid metabolism, a hallmark of carcinogenesis, may play potential roles in cervical carcinoma, assisting the prognosis prediction.Materials and MethodsA regression analysis was conducted to identify the ones with the most frequent variation in mutations and CNV changes in lactate metabolism‐related (L‐related) genes, after which a prognostic nomogram was built based on selected genes and clinical features by machine learning methods.ResultsEGLN1, IL1, IL12RB1, ENO1, and 10 other genes had the most frequent changes and prognostic differences in overall survival (OS). The lactated associated risk (LAR) score model can distinguish the patients in OS (p = 0.046, HR = 101.9, 95%CI 1.1–9447.6), and together with clinical features has a higher AUC (AUC = 0.839). Furthermore, CD8+ T, activated CD4+ memory T and resting mast cells were significantly negatively associated with the LAR score.ConclusionsLactic acid metabolism is closely related to the prognosis of cervical carcinoma, where the immune microenvironment may play an important role.