bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teledrive: An Embodied AI Based Telepresence System
Authors: Banerjee Snehasis , Paul Sayan , Roychoudhury Ruddradev , Bhattacharya Abhijan , Sarkar Chayan , Sau Ashis , Pramanick Pradip , Bhowmick Brojeshwar 
Published: July 2024

AbstractThis article presents ‘Teledrive’, a telepresence robotic system with embodied AI features that empowers an operator to navigate the telerobot in any unknown remote place with minimal human intervention. We conceive Teledrive in the context of democratizing remote ‘care-giving’ for elderly citizens as well as for isolated patients, affected by contagious diseases. In particular, this paper focuses on the problem of navigating to a rough target area (like ‘bedroom’ or ‘kitchen’) rather than pre-specified point destinations. This ushers in a unique ‘AreaGoal’ based navigation feature, which has not been explored in depth in the contemporary solutions. Further, we describe an edge computing-based software system built on a WebRTC-based communication framework to realize the aforementioned scheme through an easy-to-use speech-based human-robot interaction. Moreover, to enhance the ease of operation for the remote caregiver, we incorporate a ‘person following’ feature, whereby a robot follows a person on the move in its premises as directed by the operator. Moreover, the system presented is loosely coupled with specific robot hardware, unlike the existing solutions. We have evaluated the efficacy of the proposed system through baseline experiments, user study, and real-life deployment.
Who Am I? Self-concept in Adults with Cystic Fibrosis: Association with Anxiety and Depression
Authors: Harrigan Maggie , Mulrennan Siobhain , Jessup Melanie , Waters Phoebe , Bennett Kellie 
Published: July 2024

AbstractCystic Fibrosis (CF) is a progressive condition resulting in reduced lung function and strongly associated with elevated anxiety and depression symptoms. Self-concept refers to an individual’s overarching sense of identity, a positive level of which is widely associated with reduced anxiety and depression. There is a significant lack of self-concept research within CF. This study explores the association between self-concept and anxiety and depression in adults with CF. 64 adults living with CF in Western Australia completed validated online questionnaires (Generalised Anxiety Disorder-7, Patient Health Questionnaire-9, Tennessee Self-Concept Questionnaire 2: Short-Form) and consented to the collection of medical data. Descriptive, t-test, correlation and multiple regression analysis were undertaken. Higher levels of self-concept were associated with lower levels of anxiety and depression symptoms. Lower self-concept levels were a significant predictor of increased anxiety and depression symptoms after accounting for physical health status. Mean self-concept scores for those who required mental health intervention were significantly lower compared to those that did not. This study identifies a significant relationship between self-concept and anxiety and depression in adults with CF. Further research is required to establish causation and test the feasibility of self-concept interventions in reducing anxiety and depression symptoms.
Conformal predictions for probabilistically robust scalable machine learning classification
Authors: Carlevaro Alberto , Alamo Teodoro , Dabbene Fabrizio , Mongelli Maurizio 
Published: July 2024

AbstractConformal predictions make it possible to define reliable and robust learning algorithms. But they are essentially a method for evaluating whether an algorithm is good enough to be used in practice. To define a reliable learning framework for classification from the very beginning of its design, the concept of scalable classifier was introduced to generalize the concept of classical classifier by linking it to statistical order theory and probabilistic learning theory. In this paper, we analyze the similarities between scalable classifiers and conformal predictions by introducing a new definition of a score function and defining a special set of input variables, the conformal safety set, which can identify patterns in the input space that satisfy the error coverage guarantee, i.e., that the probability of observing the wrong (possibly unsafe) label for points belonging to this set is bounded by a predefined $$\varepsilon$$
ε
error level. We demonstrate the practical implications of this framework through an application in cybersecurity for identifying DNS tunneling attacks. Our work contributes to the development of probabilistically robust and reliable machine learning models.
Detection Method of Manipulator Grasp Pose Based on RGB-D Image
Authors: Huang Cheng , Pang Zhen , Xu Jiazhong 
Published: July 2024

AbstractIn order to better solve the visual detection problem of manipulator grasping non-cooperative targets, we propose a method of grasp pose detection based on pixel point and feature fusion. By using the improved U2net network as the backbone for feature extraction and feature fusion of the input image, and the grasp prediction layer detects the grasp pose on each pixel. In order to adapt the U2net to grasp pose detection and improve its detection performance, we improve detection speed and control sampling depth by simplifying its network structure, while retaining some shallow features in feature fusion to enhance its feature extraction capability. We introduce depthwise separable convolution in the grasp prediction layer, further fusing the features extracted from the backbone to obtain predictive feature maps with stronger feature expressiveness. FocalLoss is selected as the loss function to solve the problem of unbalanced positive and negative samples in network training. We use the Cornell dataset for training and testing, perform pixel-level labeling on the image, and replace the labels that are not conducive to the actual grasping. This adaptation helps the dataset better suit the network training and testing while meeting the real-world grasping requirements of the manipulator. The evaluation results on image-wise and object-wise are 95.65% and 91.20% respectively, and the detection speed is 0.007 s/frame. We also used the method for actual manipulator grasping experiments. The results show that our method has improved accuracy and speed compared with previous methods, and has strong generalization ability and portability.
High rate of potentially inappropriate medication use in older people: a case–control study
Authors: Érszegi András , Csupor Dezső , Bodó Gabriella , Engi Zsófia , Bahar Muh. Akbar , Matuz Mária , Benkő Ria , Pető Zoltán , Viola Réka 
Published: July 2024

AbstractAnnually, 172 million fall events cause temporary or permanent impairment in older adults, and this number is increasing. Contributing factors that increase the risk for falls include age, polypharmacy, and malnutrition. This study evaluated medications mainly included in the EU(7)-PIM (potentially inappropriate medication) list. From March 21, 2022, to July 6, 2022, 945 patients who experienced a fall and visited the Department of Emergency Medicine at the Albert Szent-Györgyi Health Centre of the University of Szeged in Hungary. Data from 886 patients were collected (study group). The control group included 1364 patient data collected from three general practice in Hungary. The use of ≥ 2 EU(7)-PIM drugs was found to be associated with increased risk for falls (adjusted odds ratio [AOR], 1.38; 95% confidence interval [CI] 1.01–1.88). Piracetam (AOR, 1.81; 95% CI, 1.28–2.57) and trimetazidine (AOR, 1.62; 95% CI, 1.17–2.24) were associated with increased risk for falls. Doxazosin was associated with a low risk for falls (AOR, 0.59; 95% CI, 0.41–0.86). Tiapride (AOR, 3.54; 95% CI, 1.75–7.17), gliclazide (AOR, 1.57; 95% CI, 1.02–2.43), and vinpocetine (AOR, 1.95; 95% CI, 1.29–2.95) are not included in the EU(7)-PIM list; however, they are associated with increased risk for falls. Long-acting benzodiazepines (AOR, 1.79; 95% CI, 1.20–2.68), antidepressants (AOR, 1.89; 95% 95% CI, 1.37–2.61), serotonin–norepinephrine reuptake inhibitor (AOR, 2.82; 95% CI, 1.41–5.67; p < 0.01), and selective serotonin reuptake inhibitor (AOR, 1.88; 95% CI, 1.24–2.85) were also associated with increased risk for falls. However, Z-drugs were associated with a low risk for falls (AOR, 0.57; 95% CI, 0.36–0.92). With the help of this tool, trimetazidine and piracetam are filtered as EU(7)-PIM drugs associated with increased risk for falls.
Association between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study
Authors: Bålsrud Pia , Ulven Stine M. , Ottestad Inger , Retterstøl Kjetil , Schwab Ursula , Holven Kirsten B. 
Published: July 2024

AbstractFrailty has been linked to inflammation and changes in body composition, but the findings are inconsistent. To explore this, we used the Frailty Index (FI) definition to (1) investigate the association between levels of inflammatory markers (baseline) and change in FI score after 8 years of follow-up and (2) investigate the longitudinal associations between inflammatory markers, body composition, and frailty. Home-dwelling elderly (≥ 70 years) were invited to participate in the study and re-invited to a follow-up visit 8 years later. This study includes a total of 133 participants. The inflammatory markers included were high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and glycoprotein acetyls (Gp-acetyls). We used the body composition markers fat mass, fat-free mass, and waist circumference. The FI score consisted of 38 variables. Additional clinical assessments such as blood pressure and body mass index (BMI), as well as information about daily medications, were collected at both visits. Linear regression model and Spearman’s rank correlation were used to investigate associations. We showed that the FI score increased after 8 years, and participants with higher hs-CRP levels at baseline had the largest change in the FI score. Changes in fat mass were significantly correlated with changes in hs-CRP and IL-6, and changes in waist circumference were significantly correlated with changes in TNF-α. The use of drugs increased during the 8 years of follow-up, which may have attenuated the associations between inflammation and frailty. However, elevated concentrations of hs-CRP in the elderly may be associated with an increased risk of frailty in subsequent years.
Intratumoral Delivery of Genetically Engineered Anti-IL-6 Trans-signaling Therapeutics
Authors: Bento Raphaela , Scheller Jürgen , Parekkadan Biju 
Published: July 2024

AbstractInterleukin-6 (IL-6) is a highly pro-inflammatory cytokine involved in the etiopathology of several inflammatory diseases and cancer. As so, the inhibition of IL-6 signaling pathways has emerged as an attractive therapeutic avenue for the treatment of several chronic diseases. Since IL-6 trans-signaling was described as the pathological branch of IL-6, selective inhibitors were developed. Next-generation variants with increased trans-signaling specificity and potency emerged as great candidates for the treatment of several diseases, with reduced off-target effects. The highly time-consuming and costly processes involving recombinant protein production, however, have hampered the progress of anti-cytokine pharmaceuticals in clinic so far. Herein, we developed gene therapeutic modalities of IL-6-trans-signaling inhibitors as alternatives for sustained recombinant protein secretion. By using an IL-6-dependent lymphoma cell line and xenograft tumor model, we demonstrated the superior inhibitory potential of second-generation anti-IL-6 trans-signaling therapeutic. We compared the efficiency of distinct gene delivery modalities using a bioluminescent biomarker probe and observed consistent protein production via cell-based delivery. When delivered intratumorally, genetically engineered sgp130FlyRFc-secreting cells significantly reduced tumor burden and increased animal survival, representing a promising therapeutic avenue to be explored in clinically relevant gene delivery applications.
Reshoring manufacturing: the influence of industry 4.0, Covid-19, and made-in effects
Authors: Stentoft Jan , Mikkelsen Ole Stegmann , Wickstrøm Kent Adsbøll 
Published: July 2024

AbstractEmpirical investigations of how the reshoring of manufacturing is affected by Industry 4.0 technologies, supply chain disruptions, and made-in effects are rare in the extant academic literature. This paper contains an empirical analysis of how these variables affect reshoring and reshoring intentions. Results from a 2022 questionnaire survey including 152 offshoring manufacturing firms show that reshoring and reshoring intentions are associated positively with investments in automation in manufacturing, and with employee made-in. Results also showed that while Covid-19 associated disruptions increased firms’ reshoring intentions equally across firm sizes, smaller and larger firms reacted quite differently towards more well-known disruption types: larger firms decreasing reshoring intentions with higher levels of uncertainty and smaller firms increasing reshoring intentions with higher levels of uncertainty. These results point to the importance of creating consciousness about the dynamics of production localization and how firm-level and situation-specific contingencies may interfere with Industry 4.0 technology-, supply chain disruption-, and made-in effects on strategic reshoring decisions.
Blunt Trauma Neck with Thyroid Cartilage Subluxation with no External Sign
Authors: Ahmad Zeeshan , Singh Kriti 
Published: July 2024

AbstractTrauma to the neck can produce catastrophic results as neck houses plethora of vital structures and is relatively an unprotected anatomical territory. Blunt trauma to the neck, excluding cervical spine injuries, represents only 5% of all neck trauma, but can be very challenging to assess since its presentation is often delayed. Penetrating injuries, on the other hand, are more common, and even when they seem to be only superficial and minor, always need thorough investigation and observation. Primary stabilization of the patient followed by an extensive evaluation needs to be done in all cases of neck trauma. CECT neck and thorax along with fibreoptic laryngoscopy remain the main modalities of diagnosis following a neck trauma. The initial approach to any kind of neck injury, whether penetrating or blunt, is performed according current Advanced Trauma Life Support (ATLS) or European Trauma Course (ETC) protocols, which both use the structured ‘ABCD’ approach. A motor vehicle accident (MVA) remains the most common cause of blunt neck injury, causing direct pressure to the anterior neck from the dashboard, steering wheel or airbag deployment. Direct pressure to the neck is transduced to the trachea and causes compression of the oesophagus against the cervical spine. Laryngotracheal trauma continues to be a rare entity and is the second most common cause of death in patients with head and neck trauma after intracranial injury. Only 0.5% of multiple trauma patients were reported to have injury to the airway at any level. Stabilize the airway first. Immediate surgical airway procedure can be necessary in less familiar circumstances and environments. If possible, define landmarks before the procedure. Defining anatomical zones is useful in penetrating injuries, although these do not guide diagnostic or therapeutic management completely. In unstable patients, elective surgical exploration is recommended instead of extensive diagnostic work-up. Unstable patients still need immediate exploration, whereas all stable patients will first be assessed with clinical examination and CT angiography and fibreoptic laryngoscopy. Thus the take home message is to consider all neck injuries an emergency and proceed with the diagnosis and management without delay.
Systematic Curiosity as an Integrative Tool for Human Flourishing: A Conceptual Review and Framework
Authors: Le Cunff Anne-Laure 
Published: July 2024

AbstractThis paper reviews seventy years of theoretical research and proposes systematic curiosity as an integrative tool for human flourishing with a focus on four key aspects: firstly, acknowledge curiosity’s multidimensional nature instead of harmonizing its complex taxonomy; secondly, emphasizing intentional curiosity as opposed to impulsive curiosity; thirdly, prioritizing domain-general curiosity for broader applicability across educational, organizational, and therapeutic settings; and lastly, focusing on curiosity as a developable skill rather than an innate trait. By segmenting systematic curiosity into cognitive, emotional, and behavioral components, and relating these to interactions with the self, others, and the world, the framework aims to apply across the spectrum of human experience. Furthermore, the framework encourages an exploration of various evidence-based activities for flourishing so individuals can discover the most suitable strategies for their specific context. Implications for both theory and practice are examined, limitations are discussed, and avenues for future research are suggested.
The intensive care unit psychosocial care scale: validity and reliability study in cardiac surgery patients
Authors: Yaman Aktaş Yeşim , Karabulut Neziha 
Published: July 2024

AbstractThis study aimed to test the validity and reliability of the ICU Psychosocial Care Scale in Turkish, which was developed to measure the psychosocial care of cardiac critical patients. This study was a methodological design. The study sample consisted of 180 critically ill cardiac patients meeting the inclusion criteria. The study used the ICU-Psychosocial Care (ICU-PC) Scale and The Intensive Care Experiences Scale for data collection. Data were analyzed using SPSS 22.0 and AMOS V 24.0 statistical package programs. Content validity, construct validity, reliability and concurrent validity tests were performed. The sample (n = 180) was predominantly male (66.1%) with a mean age of 65.96 ± 15.46 years. Confirmatory factor analysis was applied to confirm the 3-dimensional and 14-item structure of the scale. The fit indices of the scale were found to be χ2 = 89.24, df = 52, χ2/df = 1.716, goodness of fit index = 0.94, comparative fit index = 0.97, incremental fit index = 0.97, Tucker-Lewis index = 0.95, root mean square error of approximation = 0.05, standardized root mean square residual = 0.05. Cronbach’s alpha coefficient of ICU-PC scale was 0.87. The ICU-PC scale is a valid, reliable and distinctive scale in assessing the psychosocial care of critically ill cardiac patients.
Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State
Authors: Pan Gaojie , Zhao Bing , Zhang Mutian , Guo Yanan , Yan Yuhua , Dai Dan , Zhang Xiaoxi , Yang Hui , Ni Jinfei , Huang Zhili , Li Xia , Duan Shumin 
Published: July 2024

AbstractThe nucleus accumbens (NAc) plays an important role in various emotional and motivational behaviors that rely on heightened wakefulness. However, the neural mechanisms underlying the relationship between arousal and emotion regulation in NAc remain unclear. Here, we investigated the roles of a specific subset of inhibitory corticotropin-releasing hormone neurons in the NAc (NAcCRH) in regulating arousal and emotional behaviors in mice. We found an increased activity of NAcCRH neurons during wakefulness and rewarding stimulation. Activation of NAcCRH neurons converts NREM or REM sleep to wakefulness, while inhibition of these neurons attenuates wakefulness. Remarkably, activation of NAcCRH neurons induces a place preference response (PPR) and decreased basal anxiety level, whereas their inactivation induces a place aversion response and anxious state. NAcCRH neurons are identified as the major NAc projection neurons to the bed nucleus of the stria terminalis (BNST). Furthermore, activation of the NAcCRH-BNST pathway similarly induced wakefulness and positive emotional behaviors. Taken together, we identified a basal forebrain CRH pathway that promotes the arousal associated with positive affective states.
Advances of Synergistic Electrocatalysis Between Single Atoms and Nanoparticles/Clusters
Authors: Luo Guanyu , Song Min , Zhang Qian , An Lulu , Shen Tao , Wang Shuang , Hu Hanyu , Huang Xiao , Wang Deli 
Published: July 2024

AbstractCombining single atoms with clusters or nanoparticles is an emerging tactic to design efficient electrocatalysts. Both synergy effect and high atomic utilization of active sites in the composite catalysts result in enhanced electrocatalytic performance, simultaneously provide a radical analysis of the interrelationship between structure and activity. In this review, the recent advances of single-atomic site catalysts coupled with clusters or nanoparticles are emphasized. Firstly, the synthetic strategies, characterization, dynamics and types of single atoms coupled with clusters/nanoparticles are introduced, and then the key factors controlling the structure of the composite catalysts are discussed. Next, several clean energy catalytic reactions performed over the synergistic composite catalysts are illustrated. Eventually, the encountering challenges and recommendations for the future advancement of synergistic structure in energy-transformation electrocatalysis are outlined.
Improvement in battery technologies as panacea for renewable energy crisis
Authors: Ajibade Hafeez , Ujah Chika Oliver , Nnakwo Kingsley C. , Kallon Daramy V. V. 
Published: July 2024

AbstractThis review article explores the critical role of efficient energy storage solutions in off-grid renewable energy systems and discussed the inherent variability and intermittency of sources like solar and wind. The review discussed the significance of battery storage technologies within the energy landscape, emphasizing the importance of financial considerations. The review highlighted the necessity of integrating energy storage to balance supply and demand while maintaining grid system stability. The review thoroughly explored the characteristics and applications of lead-acid and lithium batteries. It drew distinctions and emphasized their safety and application advantages. The comparative review covered key factors, including cycle life, power density, energy density, efficiency, and cost considerations. Additionally, the article explored future trends, emerging technologies, and research directions. The findings of the review revealed that each battery technology offers unique advantages, presenting a challenge in selecting a preferred option for diverse applications. Furthermore, the review discussed the Total Cost of Ownership (TCO) of batteries, considering factors beyond the initial investment, with a specific emphasis on economic viability. This comprehensive approach provided a valuable tool for making informed decisions regarding the adoption of battery storage solutions in the pursuit of a sustainable energy future.