bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Sertifikasi Halal terhadap Minat Beli Konsumen Mixue pada Mahasiswa Fakultas Agama Islam (FAI) UNWAHA
Authors: Ashlihah  , Hasyim Rois 
Published: August 2024

Sertifikasi halal penting bagi konsumen Muslim karena memberikan jaminan bahwa mereka dapat memilih makanan yang baik bagi mereka dan mematuhi aturan agama. Mengetahui kualitas makanan halal berdasarkan label halal yang tertera pada produk tentunya akan mendatangkan minat yang besar bagi konsumen ketika memutuskan untuk membeli dan mengkonsumsi makanan halal. Ice Cream Mixue dibuka pertama kali pada tahun 2020, dan dengan cepat menjadi topik hangat karena harganya yang terjangkau dan rasanya yang tidak mengecewakan. Alhasil, es krim tersebut viral di media sosial, hingga mahasiswa UNWAHA khususnya Jurusan Agama Islam pun tertarik dan ingin membelinya.Tingkat pembeliannya sangat tinggi dibandingkan dengan makanan dan minuman lainya, namun terdapat beberapa perdebatan mengenai kehalalanya.Oleh karena itu, penelitian ini bertujuan untuk mengetahui dampak sertifikasi halal terhadap niat beli konsumen es krim mixue di kalangan mahasiswa FAI (Fakultas Agama Islam) UNWAHA. Metode pendekatan yang digunakan dalam penelitian ini adalah deskriptif kuantitatif. Regresi linier sederhana digunakan untuk analisis data.Teknik pengambilan sampel non-probabilitas, yaitu pengambilan sampel acak, digunakan untuk pengambilan sampel,terdapat 94 responden yang dipilih .Dari hasil uji t diperoleh nilai t hitung sebesar 7,498 > 2,279 dan nilai signifikansi < 0,000. 0,05 maka dapat disimpulkan hipotesis ini H0 ditolak dan H1 diterima. Artinya terdapat pengaruh antara sertifikasi halal terhadap minat beli konsumen es krim mixue pada mahasiswa FAI (Fakultas Agama Islam) UNWAHA.
Diversifikasi Produk Nutrisi Berbahan Dasar Ikan Lele pada Kelompok Nelayan Wanita Kab. Mempawah sebagai Salah Satu Upaya Penanganan Stunting
Authors: Fitriagustiani Fitriagustiani , Pasmawati Pasmawati , Khairillah Yuyun Nisaul , Pratama Sandi Fransisco , Alang Hasria 
Published: August 2024

Poor nutritional status of the community leads to weak human development index (HDI) values. Increasing interest in fish consumption, which is rich in diverse nutritional sources, can be a solution to improved people nutritional status in coastal communities whose livelihood marine-dependent. Fish is known as a good source of a high quality protein. This nutritional source plays an important role to provide the nutrition of pregnant women and the development of toddlers. Food diversification by using aquaculture products is expected to be one solution to increased public interest in consuming fish and also could be away to increase the selling value of fishery products. This social service aims to provide information in utilizing the fishery products (i.e Catfish) as a food diversification materials to prevent stunting in the Pak Bulu village community, Anjongan sub-district, Mempawah Regency. The stages of this activity include 1) Survey and analysis of community conditions, 2) Stunting education and introduction to the process of food diversification fish based. This community Service activities are expected to increase knowledge and skills in processing fishery products. Therefore, it can increase fish consumption in the community and become one of the solution to prevent stunting and also could be a way to improve the community's economy.
Tongue color parameters in predicting the degree of coronary stenosis: a retrospective cohort study of 282 patients with coronary angiography
Authors: Li Jieyun , Xiong Danqun , Hong Leixin , Lim Jiekee , Xu Xiangdong , Xiao Xinang , Guo Rui , Xu Zhaoxia 
Published: August 2024

PurposeThis retrospective cohort study aimed to analyze the relationship between tongue color and coronary artery stenosis severity in 282 patients after underwent coronary angiography.MethodsA retrospective cohort study was conducted to collect data from patients who underwent coronary angiography in the Department of Cardiology, Shanghai Jiading District Central Hospital from October 1, 2023 to January 15, 2024. All patients were divided into four various stenosis groups. The tongue images of each patient was normalized captured, tongue body (TC_) and tongue coating (CC_) data were converted into RGB and HSV model parameters using SMX System 2.0. Four supervised machine learning classifiers were used to establish a coronary artery stenosis grading prediction model, including random forest (RF), logistic regression, and support vector machine (SVM). Accuracy, precision, recall, and F1 score were used as classification indicators to evaluate the training and validation performance of the model. SHAP values were furthermore used to explore the impacts of features.ResultsThis study finally included 282 patients, including 164 males (58.16%) and 118 females (41.84%). 69 patients without stenosis, 70 patients with mild stenosis, 65 patients with moderate stenosis, and 78 patients with severe stenosis. Significant differences of tongue parameters were observed in the four groups [TC_R (P = 0.000), TC_G (P = 0.003), TC_H (P = 0.001) and TC_S (P = 0.024),CC_R (P = 0.006), CC_B (P = 0.023) and CC_S (P = 0.001)]. The SVM model had the highest predictive ability, with AUC values above 0.9 in different stenosis groups, and was particularly good at identifying mild and severe stenosis (AUC = 0.98). SHAP value showed that high values of TC_RIGHT_R, low values of CC_LEFT_R were the most impact factors to predict no coronary stenosis; high CC_LEFT_R and low TC_ROOT_H for mild coronary stenosis; low TC_ROOT_R and CC_ROOT_B for moderate coronary stenosis; high CC_RIGHT_G and low TC_ROOT_H for severe coronary stenosis.ConclusionTongue color parameters can provide a reference for predicting the degree of coronary artery stenosis. The study provides insights into the potential application of tongue color parameters in predicting coronary artery stenosis severity. Future research can expand on tongue features, optimize prediction models, and explore applications in other cardiovascular diseases.
Long-term outcomes of transcatheter atrial septal defect closure: a single-center retrospective study
Authors: Honghiranrueng Lalita , Roymanee Supaporn , Wongwaitaweewong Kanjarut , Jarutach Jirayut , Buntharikpornpun Rujira 
Published: August 2024

BackgroundTranscatheter atrial septal defect (ASD) closure is the primary approach for treating ASD secundum; however, data on long-term outcomes remain limited. This study aimed to elucidate the prevalence of adverse outcomes following transcatheter ASD closure in a diverse population.MethodsThis retrospective cohort study was conducted at the Songklanagarind Hospital and included patients who underwent transcatheter ASD closure between January 2010 and August 2021.ResultsThe study included 277 patients who completed follow-up for at least 1 year, with varying ages: &lt;25 years (31%), 25–40 years (19%), 40–60 years (34%), and &gt;60 years (16%). The median follow-up duration was 37 months (interquartile range: 20, 61). The overall mortality rate was 1.8%, and no deaths were attributed to device-related complications. Hospitalization due to heart failure occurred in 0.7% of the cases. Most patients improved or stabilized based on the New York Heart Association functional class. Adverse outcomes included new-onset atrial fibrillation (prevalence: 2.7%) and pulmonary hypertension (prevalence: 0.6%). The resolution of pulmonary hypertension varied among age groups, with 100% resolution in patients &lt;25 years. Multivariate analysis identified male sex, overweight, and history of stroke to be significantly associated with adverse outcomes after transcatheter ASD closure.ConclusionTranscatheter ASD closure was safe and effective, with age not being a limiting factor for success. Male sex, being overweight, and a history of stroke were associated with adverse outcomes. These findings contribute to our understanding of the long-term outcomes following ASD closure.
Identification of immune-related endoplasmic reticulum stress genes in proliferative diabetic retinopathy using bioinformatics analysis
Authors: Chen Han , Chen Enguang , Liu Miaomiao , Wang Jianhui , Yin Jiawei , Zhao Peiquan , Xu Yu 
Published: August 2024

BackgroundProliferative diabetic retinopathy (PDR) is a severe complication of diabetes, and understanding its molecular mechanisms is crucial. Endoplasmic reticulum (ER) stress has been implicated in various diseases, including diabetic complications. This study aims to elucidate ER stress-related biomarkers in PDR, providing insights into the underlying molecular pathways.MethodsWe analyzed two independent PDR datasets, GSE102485 and GSE60436. The GSE102485 dataset (22 PDR and 3 normal samples) was the primary dataset for comprehensive analyses, including differential expression, functional enrichment, PPI network construction, immune cell infiltration, and drug prediction. The GSE60436 dataset (6 PDR and 3 normal samples) was used for validation. In vitro experiments using human umbilical vein endothelial cells (HUVECs) in a high-glucose environment were conducted to validate key bioinformatics outcomes. Western blotting assessed protein levels of ER stress markers (TRAM1 and TXNIP).ResultsDifferential expression analysis identified 2451 genes, including 328 ER stress-related genes. Functional analysis revealed enrichment in ER stress-related processes and pathways. Hub genes (BCL2, CCL2, IL-1β, TLR4, TNF, TP53) were identified, and immune infiltration analysis showed altered immune cell proportions. Validation in GSE60436 and in vitro confirmed ER stress gene dysregulation. Drug prediction suggested potential small molecules targeting ER stress markers.ConclusionThis study provides a comprehensive molecular characterization of ER stress in PDR, highlighting altered biological processes, immune changes, and potential therapeutic targets. The identified hub genes and small molecules offer avenues for further investigation and therapy development, enhancing understanding of PDR pathogenesis and aiding targeted intervention creation.
Synergistically improved cardiovascular outcomes in type 2 diabetes mellitus patients with combined treatment of SGLT-2 inhibitors and pioglitazone
Authors: Li Yan-Rong , Wang Chih-Ching , Liu Chi-Hung , Yen Chieh-Li , Wu Victor Chien-Chia , Huang Evelyn Jou-Chen , Lee Ching-Yu , Hsiao Ching-Chung 
Published: August 2024

BackgroundSodium-glucose co-transporter-2 inhibitors (SGLT2i) have cardiovascular (CV) benefits, particularly in reducing the risk of heart failure (HF). Pioglitazone (Pio) has shown potential in decreasing the risks of recurrent stroke, non-fatal myocardial infarction (MI), and all-cause mortality but increasing risks of HF. Our study aimed to examine the synergistic effects on CV outcomes in patients with type 2 diabetes mellitus (T2DM) who received the combined treatment of SGLT2i and Pio.Materials and methodsA total of 117,850 patients with T2DM and without a history of HF were selected as the observational study cohort from the Chang Gung Research Database (CGRD) in Taiwan between January 1, 2016, and December 31, 2019. The primary composite outcome was 4-point major adverse CV events (4P-MACE), including CV death, non-fatal MI, non-fatal ischemic stroke, and hospitalization for HF. The study was divided into four groups: a combined treatment group in which SGLT2i and Pio were used, two individual groups in which SGLT2i or Pio was used separately, and a reference group (non-study drugs).ResultsCombined treatment of SGLT2i and Pio had the lowest risk of 4P-MACE (adjusted hazard ratio [aHR], 0.66; 95% confidence interval [CI], 0.54–0.80) compared with the reference group after a mean follow-up of 2.2 years. There was no significant difference in risks of hospitalization for HF (adjusted subdistribution hazard ratio, 0.73; 95% CI, 0.49–1.07) compared with the reference group.ConclusionsIn T2DM patients without HF, the combined treatment with SGLT2i and Pio may synergistically provide CV benefits without increasing risks of HF.
Ferroptosis and iron metabolism in diabetes: Pathogenesis, associated complications, and therapeutic implications
Authors: Jin Eun-Ju , Jo Yunju , Wei Shibo , Rizzo Manfredi , Ryu Dongryeol , Gariani Karim 
Published: August 2024

Diabetes mellitus is a complex chronic disease, considered as one of the most common metabolic disorders worldwide, posing a major threat to global public health. Ferroptosis emerges as a novel mechanism of programmed cell death, distinct from apoptosis, necrosis, and autophagy, driven by iron-dependent lipid peroxidation accumulation and GPx4 downregulation. A mounting body of evidence highlights the interconnection between iron metabolism, ferroptosis, and diabetes pathogenesis, encompassing complications like diabetic nephropathy, cardiomyopathy, and neuropathy. Moreover, ferroptosis inhibitors hold promise as potential pharmacological targets for mitigating diabetes-related complications. A better understanding of the role of ferroptosis in diabetes may lead to an improvement in global diabetes management.In this review, we delve into the intricate relationship between ferroptosis and diabetes development, exploring associated complications and current pharmacological treatments.
Numerical modeling the impacts of increasing groundwater pumping upon discharge decline of the BL Spring located in Xilin Gol League in east inner Mongolia, China
Authors: Xiao Han , Yang Yu , Liu Qiyuan , Zang Yongge , Lian Xinying , Xia Fu , Jiang Yonghai 
Published: August 2024

Spring discharge decline induced by increasing groundwater pumping under the background of increasing water demand for agricultural, industrial, and domestic utilizations has been recognized as a significant geo-environmental issue which poses a great threat to springshed eco-environmental safety. In this study, numerical approach was utilized and a series of 3D groundwater flow models based on the MODFLOW module were developed to simulate current-stage and future trends of spring discharges under the impacts of increasing groundwater pumping due to the rapid development of tourism in the BL spring located in Xilin Gol League in east Inner Mongolia (China), for the purpose of understanding the responses of spring discharges to various groundwater pumping scenarios in future. Simulation results indicated that: (1) spring discharge has reduced from 201.4 m3/d to 193.7 m3/d (reduction ratio of 3.80%) under current-stage pumping scheme; (2) the spring-discharge-affected zone is 2.025 km2 under current-stage pumping scheme and groundwater pumping within this zone contributes to spring discharge decline; (3) impact of the pumping well located nearest to the BL spring is the most significant while impact of the pumping well located farthest to the BL spring is negligible; and (4) spring discharge would reduce 25%, 50%, 75%, and 100% if total pumping rate of the seven abstraction wells would increase from 45.8 m3/d (current-stage pumping scheme) to 297.7, 586.2, 888.5, and 1,176 m3/d, respectively. The outcome of this study can provide useful references for advising sustainable groundwater exploitation strategies to meet the requirement of groundwater supply under the premise of spring discharge management and eco-environmental protection.
Assessment of h-index and associated demographic and academic parameters for academic hematologists in Canada
Authors: Ordaz Daniel Josué Guerra , Roy Jean , Ahmad Imran , Kaouache Mohammed , Ramchatesingh Brandon , Whitelaw Sera , Nikonova Anna , Bredeson Chris , Litvinov Ivan V. 
Published: August 2024

IntroductionThe h-index measures researchers’ productivity by assessing simultaneously the number of publications and citations. We aimed to assess the factors that could influence h-index for hematologists practicing in academic institutions in Canada.MethodsWe identified universities with a hematology residency training programs/fellowships using the Canadian Resident Matching Service (CaRMS) website. We obtained the listing of faculty, sex, and academic ranks by consulting faculty directories or by contacting respective departments/universities, when directories were unavailable or incomplete. For each faculty member, we obtained years since Royal College of Physicians’ and Surgeons of Canada certification or equivalent, receipt of Canadian Institute of Health Research (CIHR) grants within the last 5 years, attainment of graduate degrees (M.Sc., Ph.D., other), and the h-index.ResultsThe data included information collected from 372 individuals (171 females) across Canada (Atlantic Provinces: 13; Quebec: 89; Ontario: 182; Prairie Provinces: 59; British Columbia: 29). Univariate analysis showed that male sex, practicing in British Columbia, longer duration since specialty certification, completion of an M.Sc. or a Ph.D. degree, attaining a higher academic rank and receiving CIHR funding were associated with higher h-index. The results of the univariate analysis were concordant with the multivariate analysis, except that practicing in Ontario was also associated with higher h-index.ConclusionThis study provides details on the h-index curve/parameters for academic productivity of hematologists in Canada. Importantly, based on multivariate analysis, higher h-index was associated with male sex, location of practice, years since certification, attainment of M.Sc. or Ph.D. degrees, academic rank, and recent CIHR funding.
A predictive propensity measure to enter REM sleep
Authors: Ginsberg Alexander G. , Cruz Madelyn Esther C. , Weber Franz , Booth Victoria , Diniz Behn Cecilia G. 
Published: August 2024

IntroductionDuring sleep periods, most mammals alternate multiple times between rapid-eye-movement (REM) sleep and non-REM (NREM) sleep. A common theory proposes that these transitions are governed by an “hourglass-like” homeostatic need to enter REM sleep that accumulates during the inter-REM interval and partially discharges during REM sleep. However, markers or mechanisms for REM homeostatic pressure remain undetermined. Recently, an analysis of sleep in mice demonstrated that the cumulative distribution function (CDF) of the amount of NREM sleep between REM bouts correlates with REM bout duration, suggesting that time in NREM sleep influences REM sleep need. Here, we build on those results and construct a predictive measure for the propensity to enter REM sleep as a function of time in NREM sleep since the previous REM episode.MethodsThe REM propensity measure is precisely defined as the probability to enter REM sleep before the accumulation of an additional pre-specified amount of NREM sleep.ResultsAnalyzing spontaneous sleep in mice, we find that, as NREM sleep accumulates between REM bouts, the REM propensity exhibits a peak value and then decays to zero with further NREM accumulation. We show that the REM propensity at REM onset predicts features of the subsequent REM bout under certain conditions. Specifically, during the light phase and for REM propensities occurring before the peak in propensity, the REM propensity at REM onset is correlated with REM bout duration, and with the probability of the occurrence of a short REM cycle called a sequential REM cycle. Further, we also find that proportionally more REM sleep occurs during sequential REM cycles, supporting a correlation between high values of our REM propensity measure and high REM sleep need.DiscussionThese results support the theory that a homeostatic need to enter REM sleep accrues during NREM sleep, but only for a limited range of NREM sleep accumulation.
Nutrient analysis of three low-carbohydrate diets differing in carbohydrate content
Authors: Banner Lani , Rice Bradley Beth H. , Clinthorne Jonathan 
Published: August 2024

IntroductionLow-carbohydrate diets are increasing in popularity. Despite clinical evidence demonstrating their safety and efficacy, concerns regarding the nutrient adequacy of low-carbohydrate diets persist. The aims of this study were to assess the nutrient adequacy of three 7-day meal plans that delivered 20 (VLCD20), 40 (VLCD40), and 100 (LCD100) grams of net carbohydrate per day respectively.MethodsNutrient analyses were conducted using USDA Food Data Central.ResultsAll three low-carbohydrate meal plans exceeded recommendations for vitamins A, C, D, E, K, thiamin, riboflavin, niacin, B6, folate and B12 in males and females 31–70 years and exceeded calcium recommendations for adults 31–50 years but remained below the Tolerable Upper Intake Level. VLCD40 and LCD100 met or exceeded fiber recommendations for females ages 31–70 years and were adequate for males 51–70 years. None of the meal plans contributed meaningful amounts of added sugar. The plans exceeded the Recommended Dietary Allowance for protein for adults ages 31–70 years of age but were within the Acceptable Macronutrient Distribution Range of 10–35% of energy. The plans slightly exceeded recommendations for saturated fat and sodium but were lower in these nutrients than the average American diet and had more favorable omega-6 to omega-3 and sodium to potassium ratios than is typical. All three meals plans met or exceeded the Estimated Average Requirement for micronutrients in females ages 31–50 years, the population group most likely to consume low-carbohydrate diets.DiscussionWell-constructed low-carbohydrate meal plans can be nutritionally adequate in adults.
Potential causal link between dietary intake and epilepsy: a bidirectional and multivariable Mendelian randomization study
Authors: Lai Shenglong , Xing Yazhou , Li Haiyang , Wu Du , Wang Lin , Liang Qinghua 
Published: August 2024

BackgroundEpilepsy is a common neurological disease, and dietary intake has been suggested as a potential modifiable risk factor. However, the causality of associations between dietary intake and epilepsy remains uncertain. This study aimed to investigate the potential causal relationships between various dietary intakes and epilepsy using Mendelian randomization (MR) analysis.MethodsA two-sample MR approach was employed, utilizing genetic variants associated with dietary factors as instrumental variables (IVs). Genome-Wide Association Study (GWAS) summary data on dietary intakes were obtained from the UK Biobank, while data on epilepsy were sourced from the European Bioinformatics Institute. The number of genetic variants used as IVs varied for each dietary factor. Inverse-variance weighted (IVW), weighted median, MR-Egger, and Bayesian weighted MR (BWMR) methods were used to assess causality. Multivariable MR (MVMR) was performed, adjusting for potential confounders. Sensitivity analyses were conducted to evaluate the robustness of the findings.ResultsThe study identified a significant inverse association between non-oily fish intake and epilepsy risk (OR = 0.281, 95% CI: 0.099–0.801, p = 0.018) using the IVW method. This finding was corroborated by the BWMR analysis (OR = 0.277, 95% CI: 0.094–0.814, p = 0.020). The MVMR analysis further confirmed the protective effect of non-oily fish intake on epilepsy risk after adjusting for potential confounders. In the reverse MR analysis, epilepsy was associated with reduced water intake (OR = 0.989, 95% CI: 0.980–0.997, p = 0.011).ConclusionThe present MR study provides evidence of a causal, protective relationship between non-oily fish intake and reduced epilepsy risk. Additionally, the findings suggest that epilepsy may influence water intake patterns. These results contribute to our understanding of the role of dietary factors in epilepsy and may inform dietary recommendations for the management and prevention of this condition.