bluuebunny/crossref_metadata_2025_split huggingface dataset:
The MEF2–HDAC axis controls proliferation of mammary epithelial cells and acini formation in vitro
Authors: Clocchiatti Andrea , Di Giorgio Eros , Viviani Giulia , Streuli Charles , Sgorbissa Andrea , Picco Raffaella , Cutano Valentina , Brancolini Claudio 
Published: September 2015

ABSTRACT
The myocyte enhancer factor 2 and histone deacetylase (MEF2–HDAC) axis is a master regulator of different developmental programs and adaptive responses in adults. In this paper, we have investigated the contribution of the axis to the regulation of epithelial morphogenesis, using 3D organotypic cultures of MCF10A cells as a model. We have demonstrated that MEF2 transcriptional activity is upregulated during acini formation, which coincides with exit from the proliferative phase. Upregulation of the transcription of MEF2 proteins is coupled to downregulation of HDAC7, which occurs independently from changes in mRNA levels, and proteasome- or autophagy-mediated degradation. During acini formation, the MEF2–HDAC axis contributes to the promotion of cell cycle exit, through the engagement of the CDK inhibitor CDKN1A. Only in proliferating cells can HDAC7 bind to the first intron of the CDKN1A gene, a region characterized by epigenetic markers of active promoters and enhancers. In cells transformed by the oncogene HER2 (ERBB2), acini morphogenesis is altered, MEF2 transcription is repressed and HDAC7 is continuously expressed. Importantly, reactivation of MEF2 transcriptional activity in these cells, through the use of a HER2 inhibitor or by enhancing MEF2 function, corrected the proliferative defect and re-established normal acini morphogenesis.
Fostering participation through ubiquitous media in pervasive performance
Authors: Pérez Elena 
Published: September 2015

Abstract
This article reflects on Chain Reaction (2009 and 2011), a mixed performance combining ubiquitous media with performance conventions and experimental game design. It explores the ways in which ubiquitous media were used to foster participants’ creative expression and how these strategies impacted performance conventions of spectatorship and participation. By combining performance, game and ubiquitous media in public space, it is claimed that Chain Reaction enables spectators to cross conventional thresholds and experience different participatory roles during one and the same event, going from spectator, to (performative) player, to theatre actor and to documentalist. In this way, ubiquitous media are vital to developing a performance genre that seeks to empower the cultural participant.
Le Passage – an archaeology of spatial transitions
Authors: Beyer Isabella 
Published: September 2015

Abstract
The author reflects on the usage and development of the zoom ‘passage’ and its various forms from the early cinema of the 1920s to the expanding concept of a scaling zoom towards a Cosmic View (Boerke, 1957) and the usage of cosmic zooms in todays fulldome theatres/ planetariums. Today various zoom effects are being used at daily routine. The navigation inside geographical visualization tools is naturally embedded in our daily media experience while using mobile devices, car navigational tools and other applications. All the more a critical perspective on the impact is needed. This article compares the different techniques used in Google Maps and in Fulldome theatres and argues that the usage of digital geographical tools and their inherent zoom structures change our mind concept of local environments, earth and spatial knowledge.
iCelebrate Teaching and Learning: Sharing the iPad Experience
Authors: Cavanaugh Cathy , Hargis Jace , Munns Stephen , Kamali Tayeb 
Published: September 2015

In April 2012, the federal higher education system of the United Arab Emirates (UAE) embarked on the path to national adoption of the Apple iPad as the educational computing platform. The core objective of the adoption was improved learning and degree completion among students in academic programs in support of national development goals. From the National Higher Education development document, the goals are to- "Achieve individualized student learning consistent with “Post PC Era” trends;- Introduce of challenge-based learning or other progressive classroom pedagogy;- Increased student participation and motivation;- Enhance opportunities for cross-institutional collaboration between faculty members;- Increase faculty collaboration through cross-institutional repositories of learning objects; and- Facilitate the migration to e-books." The UAE has three institutions encompassing 20 campuses serving 50,000 students in its federal higher education: UAE University provides a research-intensive experience; Zayed University, a liberal arts, comprehensive environment; and HCT, professional programs. The HCT iPad program was envisioned by HCT’s Chancellor, His Excellency Sheikh Nahayan Mabarak Al Nahayan, Minister for Higher Education and Scientific Research, and was led by the Vice Chancellor Dr Tayeb Kamali. This program builds on his history of entrepreneurship and e-learning initiatives, such as integrated wireless campus infrastructures, online learning and knowledge-management programmes, Dr Kamali has successfully built a cutting-edge institution that provides UAE youth with technological skills and the ability to innovate, while driving job creation in the region.
Effects of maternal abdominal decompression on umbilical artery and fetal middle cerebral artery blood flow
Authors: Mugerli Sara , Njenjić Gordana , Fabjan Vodušek Vesna , Lučovnik Miha 
Published: September 2015

Introduction: Maternal abdominal decompression during pregnancy could be used in an attempt to improve utero-placental blood flow. We utilized Doppler ultrasonography to investigate the effects of this procedure on blood flow in the umbilical artery and fetal middle cerebral artery.
Methods: Women (n = 23) with singleton pregnancies attending antenatal abdominal decompression were enrolled in the study. Doppler velocity waveforms were obtained from umbilical artery and fetal middle cerebral artery before and after a 30-minute decompression session. Resistance indices were compared using the Student's t - test (p < 0.05 significant).
Results: 23 healthy pregnant women were included at an average gestational age of 36+1 weeks. The mean resistance index before decompression in the umbilical artery was 0.58 (s = 0.10) and after decompression 0.54 (s = 0.07, p = 0.06). In the middle cerebral artery the values were 0.72 (s = 0.11) and 0.77 (s = 0.08), respectively (p = 0.01).
Discussion and conclusion: Significantly increased resistance index in the middle cerebral artery implies a higher fetal brain oxygenation after decompression. This is further corroborated by the trend towards a decrease in umbilical artery resistance index. The effects of decompression could be beneficial in pregnancies complicated by IUGR or hypertensive disorders of pregnancy.
Seroprevalence and correlates of Toxoplasma gondii infection in dairy cattle in northwest China
Authors: Tan Qi-Dong , Yang Xiao-Yu , Yin Ming-Yang , Hu Ling-Ying , Qin Si-Yuan , Wang Jin-Lei , Zhou Dong-Hui , Zhu Xing-Quan 
Published: September 2015

AbstractPrevalence of antibodies to Toxoplasma gondii and risk factors with infection were assessed in dairy cattle from Gansu Province and Ningxia Hui Autonomous Region (NXHAR), northwest China. In total, 1657 serum samples were collected and assayed by the modified agglutination test. The overall seroprevalence was 4.83% at a 1:100 cut-off, with titers of 1:100 in 72, 1:200 in 4, 1:400 in 4. Among the risk factors examined, no statistically significant difference was observed between T. gondii seroprevalence and regions or age of dairy cattle in the logistic regression analysis (P>0.05) and left out of the final model. However, numbers of pregnancies of dairy cattle was considered as main risk factor associated with T. gondii infection. Dairy cattle in nulliparity group (8.89%) had 6 times (OR=6.31, 95% CI, 2.69-14.83, P<0.001) higher risk of being seropositive compared to dairy cattle in 3 or above 3 pregnancies group (1.52%), followed by 1 pregnancy group (4.27%) had nearly 3 times (OR=2.89, 95% CI, 1.11-7.52, P = 0.03) higher risk of being seropositive compared to dairy cattle in 3 or above 3 pregnancies group, although no statistical difference was found between 2 pregnancies group and 3 or above 3 pregnancies group (P = 0.70). The results of this survey indicated the presence of T. gondii infection in dairy cattle in Gansu Province and NXHAR, which enriches the epidemiological data of T. gondii infection in dairy cattle in China, and is helpful to strengthen prevention and control of T. gondii infection in dairy cattle in these two regions.
A new species of Cosmocerca (Nematoda: Cosmocercidae) and other helminths in Cyrtodactylus gubaot (Squamata: Gekkonidae) from the Philippines
Authors: Bursey Charles R. , Goldberg Stephen R. , Siler Cameron D. , Brown Rafe M. 
Published: September 2015

AbstractCosmocerca leytensis sp. nov. (Ascaridida, Cosmocercidae) from the large intestine of Cyrtodactylus gubaot (Squamata: Gekkonidae) collected on Leyte Island, Philippines is described and illustrated. Cosmocerca leytensis sp. nov. is the 30
Risk factors of occurrence of Toxoplasma gondii among horses in the state of Alagoas, Brazil
Authors: Fonseca de Araújo Valença Sandra R. , Barreto Valença Rômulo M. , Pinheiro Júnior José Wilton , Feitosa de Albuquerque Pedro P. , Souza Neto Orestes L. , Mota Rinaldo Aparecido 
Published: September 2015

AbstractThe aim of the present study was to investigate the occurrence of Toxoplasma gondii among horses and its associated risk factors in Alagoas, Brazil. In total, 440 samples from 36 properties in 23 districts of the state of Alagoas were studied, covering the Leste, Agreste and Sertão mesoregions. Risk factors were evaluated through the application of an investigative questionnaire that focused on the productive, reproductive and sanitary management of herds. T. gondii infection were assayed using the immunofluorescence assay (IFA) with a cutoff point of 64; 14.4% (95% CI: 11.0%-17.8%) of - horses were seropositive. A significant association was determined between anti-T. gondii antibody presence and the consumption and storage of hay (OR = 2.08 / 95% CI: 1.20-3.62). This is the first report of T. gondii infection among horses in the state of Alagoas, Brazil.
Recent study on canine vector-borne zoonoses in southern Slovakia – serologic survey
Authors: Čabanová Viktória , Pantchev Nikola , Hurníková Zuzana , Miterpáková Martina 
Published: September 2015

AbstractOver the last decade a significant spread of Canine Vector Borne Diseases has been recorded in Central Europe. The aim of the study described here, was to collect current data on the occurrence and distribution of three major canine vector-borne pathogens in the veterinary clinical practice by a newly-developed commercial ELISA test for the detection of Dirofilaria immitis antigen as well as specific circulating antibodies to Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato. Circulating D. immitis antigen was detected in five of 180 investigated sera samples. Two of D. immitis seropositive dogs revealed also microfilariae of D. repens in the blood and three of them were negative for the presence of microfilariae in the Knott´s test. From the practical point of view, the finding of D. immitis occult infections might influence existing knowledge about distribution of this species among dogs in Central European countries. In 11.7% of the tested dogs the presence of specific antibodies against A. phagocytophilum was confirmed. Antibodies against B. burgdorferi s.l. were detected in 2.8% of tested sera samples. Coinfection with A. phagocytophilum and B. burgdorferi s.l. was observed in two dogs from Košice district in south-eastern Slovakia. Our data point toward the presence of Canine Vector Borne Diseases in the studied area. Therefore, veterinarians should include these diseases in their differential diagnosis and higher awareness should be focused also on prophylactic measures to prevent the pathogens transmission by arthropod vectors.
A New Species of Ligophorus (Monogenea: Dactylogyridae) from the gills of the Flathead Mullet Mugil cephalus (Teleostei: Mugilidae) from Mexico
Authors: Rodríguez-González Abril , Míguez-Lozano Raúl , Llopis-Belenguer Cristina , Balbuena Juan Antonio 
Published: September 2015

AbstractA new monogenean species, Ligophorus yucatanensis n. sp. from the gills of the flathead mullet Mugil cephalus from the Yucatan Peninsula, Mexico, is described. The new species can be differentiated from all other species of Ligophorus by the morphology of the accessory piece of the copulatory organ. Its main lobe is cylindrical, tunnelled expanded distally, slightly bowed with a characteristic membranous opening at level of medial bifurcation of the accessory piece, forming a thick-walled bulbshaped expansion that ends in a round labium. The secondary lobe is spatulate, straight, and shorter than the main lobe. In addition, the new species can be distinguished from other species by the morphology of the haptoral ventral bar, and the distal end of the vaginal duct. Furthermore the ventral anchors are shorter than those of all other species of Ligophorus reported in the Gulf of Mexico and Caribbean Sea. In addition, the zoogeographical records of Ligophorus spp. on the M. cephalus species complex are briefly reviewed and updated.
Biocatalytic deracemization: An efficient one-pot synthesis of (R)-α-methyl-4-pyridinemethanol using whole cells of Candida parapsilosis
Authors: Ghosh Saptarshi , Banoth Linga , Banerjee Uttam Chand 
Published: September 2015

AbstractA single-step synthesis of (R)-α-methyl- 4-pyridinemethanol from (RS)-α-methyl-4- pyridinemethanol by stereoinversion using whole cells of Candida parapsilosis is reported. Among the various strains of Candida species examined, C. parapsilosis demonstrated to have the best oxidoreductase system for stereoinversion of (RS)-α-methyl-4-pyridinemethanol. The effect of various physicochemical parameters on the stereoinversion process, were studied. Under optimized conditions approximately 97% enantiomeric excess of (R)-α-methyl-4-pyridinemethanol (eeR) was obtained with 99% yield was obtained. The optimized parameters were determined to be a substrate concentration of 5 mM, pH 8.0, 30°C incubation temperature, and a reaction time of 48 h. The reactions were also carried out in different organic solvents, and maximum stereoinversion was obtained in 1,4-dioxane with 78.4% eeR and 74.7% yield, which are lower than those in phosphate buffer. This whole cell catalysis for the preparation of (R)-α-methyl-4- pyridinemethanol is an example of a green, enantiopure synthesis of secondary alcohols.
Parameterization of a Conventional and Regenerated UHB Turbofan
Authors: Oliveira Fábio , Brójo Francisco 
Published: September 2015

AbstractThe attempt to improve aircraft engines efficiency resulted in the evolution from turbojets to the first generation low bypass ratio turbofans. Today, high bypass ratio turbofans are the most traditional type of engine in commercial aviation. Following many years of technological developments and improvements, this type of engine has proved to be the most reliable facing the commercial aviation requirements. In search of more efficiency, the engine manufacturers tend to increase the bypass ratio leading to ultra-high bypass ratio (UHB) engines. Increased bypass ratio has clear benefits in terms of propulsion system like reducing the specific fuel consumption. This study is aimed at a parametric analysis of a UHB turbofan engine focused on short haul flights. Two cycle configurations (conventional and regenerated) were studied, and estimated values of their specific fuel consumption (TSFC) and specific thrust (Fs) were determined. Results demonstrate that the regenerated cycle may contribute towards a more economic and friendly aero engines in a higher range of bypass ratio.
Design of a Ka Band GTEM Cell
Authors: Yu M. X. 
Published: September 2015

AbstractA Ka band GHz Transverse Electromagnetic (GTEM) cell with a large uniform volume is proposed in this paper. We calculated the characteristic impedance of the GTEM cell transition, and designed a wideband, low insertion loss，simple structure of the GTEM cell transition. The characteristic impedance of the main part of the GTEM cell is calculated with a new simple and effective method, and the larger uniform fields are be got by suppressed higher TE modes with narrow slot on the septum. The feasibility of the method was assessed with simulation software CST. It provides a method to solve the contradiction between the upper limit frequency and the volume of the GTEM Cell.
Digitally Controlled 4-Phase Bi-Directional Interleaved Dc-Dc Converter with Coupled Inductors / Digitāli Vadāms 4 Fāžu Divvirziena Līdzstrāvas Pārveidotājs Ar Saistītajām Droselēm
Authors: Kroics K. , Sirmelis U. , Grigans L. 
Published: September 2015

Abstract
The main advantages of multiphase interleaved DC-DC converters over single-phase converters are reduced current stress and reduced output current ripple. Nevertheless, inductor current ripple cannot be reduced only by an interleaving method. The integrated magnetic structure can be used to solve this problem. In this paper, the application of 2-phase coupled inductor designed in a convenient way by using commercially manufactured coil formers and ferrite cores is analysed to develop a 4-phase interleaved DC-DC converter. The steady state phase and output current ripple in a boost mode of the interleaved bidirectional DC-DC converter with integrated magnetics are analysed. The prototype of the converter has been built. The experimental results of the current ripple are presented in the paper.
UV-Vis studies of 800 keV Ar ion irradiated NiO thin films
Authors: Mallick P. , Mishra D.K. , Kumar P. , Kanjilal D. 
Published: September 2015

Abstract
We report the evolution of optical absorption properties of 800 keV Ar ion irradiated NiO thin films through UV-Vis characterization. Our results indicate the existence of both Mott-Hubbard (d → d transition) and charge-transfer (p → d transition) characteristic of NiO. The optical band gap of NiO increases from 3.58 to 3.75 eV when irradiated at the fluence of 5 × 1014 ions cm-2 but it does not show any remarkable variation upon 800 keV Ar ion irradiation at higher fluences. The refractive index and electron polarizability at different ion fluences have been determined from the optical band gap. Both refractive index and electron polarizability follow an opposite trend to that of the energy gap as a function of ion fluence.
The actual measurements at the tide gauges do not support strongly accelerating twentieth-century sea-level rise reconstructions
Authors: Parker A. 
Published: September 2015

AbstractContrary to what is claimed by reconstructions of the Global Mean Sea Level (GMSL) indicating accelerating sea level rates of rise over the twentieth-century, the actual measurements at the tide gauges show the sea levels have not risen nor accelerated that much. The most recent estimation by Hay et al [
Experiences on the influence of different behaviors on antioxidants and reactive oxygen species in the human skin
Authors: Lademann Jürgen , Meinke Martina C. , Lohan Silke B. , Schanzer Sabine , Darvin Maxim E. 
Published: September 2015

Abstract:Skin aging is determined by genetic aspects and by the action of free radicals. At small concentrations, these reactive molecules contribute essentially to signaling processes in the human organism. If their concentration exceeds a critical threshold, the free radicals can destroy cells and cell compartments. The human organism has developed a protective antioxidant system against the detrimental action of free radicals. Most of these antioxidants cannot be produced in the human body but have to be ingested with food rich in antioxidants, for instance with fruit and vegetables. Resonance Raman and reflectance spectroscopy was used to detect carotenoids, which represent marker substances for the whole antioxidative potential in human skin. It could be demonstrated that the antioxidant status of the skin reflects the nutritional and stress behavior of human subjects. Increasing the concentration of cutaneous antioxidants by topical or systemic application could be an appropriate way to reduce the destructive action of the free radicals. Consequently, high antioxidant concentrations in human skin might be an efficient mechanism to prevent skin aging.
Effect of manufacturing parameters and thermal treatment on the properties of tubular braids and tubular knits
Authors: Lou Ching-Wen , Lu Po-Ching , Hu Jin-Jia , Lin Jia-Horng 
Published: September 2015

AbstractTextile techniques can be applied to create two-dimensional or three-dimensional tubular fabrics. Three-dimensional tubular knits can be used in many fields, such as for medical textiles, conductive textile, composites, and tissue engineering. This study aimed to examine the effects of different yarn types on various fabrics and of different temperatures on the variations in the properties of textiles. Four types of wrapped yarn (P150, P75, S140, and S70) were made into tubular braids and knits, after which the products were thermally treated at various temperatures (120°C, 140°C, and 160°C). A shrinkage measurement, a porosity test, a braid angle test, and a tensile test were performed to evaluate the tubular braids and knits. The test results indicated that the thermal treatment temperature did not affect the porosity of the tubular braids and tubular knits. The porosity of the tubular braids was between 40.32% and 48.27%, while that of the tubular knits was between 10.15% and 35.57%. In addition, the tensile strength of both fabric types increased by 40–50%, while their displacement increased by 200–250%. In the future, the efficacy of tubular braids and tubular knits for use as vascular grafts will be examined.
Seasonal and interannual variability in runoff from the Werenskioldbreen catchment, Spitsbergen
Authors: Majchrowska Elżbieta , Ignatiuk Dariusz , Jania Jacek , Marszałek Henryk , Wąsik Mirosław 
Published: September 2015

Abstract
The results from a hydrological monitoring program of Breelva basin (Spits− bergen, Svalbard) have been analysed to improve the understanding of the Werenskiöld Glacier system’s functioning in the High Arctic. Hydrographs of a 44 km2 river basin (27 km2 of which was covered by a glacier) were analysed for the period 2007-2012. Sea− sonal discharge fluctuations were linked to glacier ablation and meteorological parameters, including atmospheric circulation types. A dichotomy was found in the discharge peaks generation during the hydrologically active season, with the main role played by snow and ice melt events during its first part and the rainfall regime dominating its second part. Foehn type strong winds played a significant role in the generation of ablation type floods (e.g. in August 2011). A simple classification of the runoff regime was applied to the examined six−year period, resulting in the identification of its three types: the ablation type (dominant in 2007 and 2009), the rainfall type (in the years 2011-2012), and the mixed type (during 2008 and 2010). According to publications the river flow season in Spitsbergen begins in June and end with freeze−up in September or at the beginning of October. Recently, this sea− son for Breelva tend to be extended with the mid−May onset and end in the second part of October. A multiannual trend was noted that reflects a growing importance of rainfalls, especially in September. Rainfall waters play a more distinct role in outflow from the Breelva catchment recently.