bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eudaimonic well‐being and tumor norepinephrine in patients with epithelial ovarian cancer
Authors: Davis Lauren Z. , Slavich George M. , Thaker Premal H. , Goodheart Michael J. , Bender David P. , Dahmoush Laila , Farley Donna M. , Markon Kristian E. , Penedo Frank J. , Lubaroff David M. , Cole Steve W. , Sood Anil K. , Lutgendorf Susan K. 
Published: June 2015

BACKGROUNDThe impact of psychological well‐being on the physiologic processes involved in cancer progression remains unclear. Prior research has implicated adrenergic signaling in tumor growth and metastasis. Given that adrenergic signaling is influenced by both positive and negative factors, the authors examined how 2 different aspects of well‐being (eudaimonic and positive affect) and psychological distress were associated with tumor norepinephrine (NE) in patients with ovarian cancer.METHODSA total of 365 women with suspected ovarian cancer completed psychosocial assessments before surgery and clinical information was obtained from medical records. Study inclusion was confirmed after histological diagnosis. Tumor NE was measured in frozen tissue samples using high‐performance liquid chromatography with electrochemical detection. Confirmatory factor analysis was used to model eudaimonic well‐being, positive affect, and psychological distress, and structural equation modeling was used to examine associations between these factors and tumor NE.RESULTSEudaimonic well‐being, positive affect, and psychological distress, modeled as distinct but correlated constructs, best fit the data (ie, compared with unitary or 2‐factor models) (root mean square error of approximation, 0.048; comparative fit index, 0.982; and standardized root‐mean‐squared residual, 0.035). Structural equation modeling analysis that included physical well‐being, stage of disease, histology, psychological treatment history, beta‐blocker use, and caffeine use as covariates was found to have good model fit (root mean square error of approximation, 0.052; comparative fit index, 0.955; and standardized root‐mean‐squared residual, 0.036) and demonstrated that eudaimonic well‐being was related to lower tumor NE (β = ‐.24 [P = .045]). In contrast, no effects were found for positive affect or psychological distress.CONCLUSIONSEudaimonic well‐being was found to be associated with lower tumor NE, independent of positive affect and psychological distress. Because adrenergic signaling is implicated in tumor progression, increasing eudaimonic well‐being may improve both psychological and physiologic resilience in patients with ovarian cancer. Cancer 2015;121:3435–43. © 2015 American Cancer Society.
Rational Design and Synthesis of a Highly Porous Copper‐Based Interpenetrated Metal–Organic Framework for High CO2 and H2 Adsorption
Authors: Bose Purnandhu , Bai Linyi , Ganguly Rakhesh , Zou Ruqiang , Zhao Yanli 
Published: June 2015

AbstractInterpenetrated metal–organic frameworks (MOFs) are often observed to show lower porosity than their non‐interpenetrating analogues. It would be highly desirable if the interpenetrated MOFs could still provide high stability, high rigidity, and optimal pore size for applications. In this work, an asymmetrical tricarboxylate organic linker was rationally designed for the construction of a copper(II)‐based microporous MOF with a twofold interpenetrated structure of Pt3O4 topology. In spite of having structural interpenetration, the activated MOF shows high porosity with a Brunauer–Emmett–Teller surface area of 2297 m2 g−1, and high CO2 (15.7 wt % at 273 K and 1 bar) and H2 uptake (1.64 wt % at 77 K and 1 bar).
An Aggregation‐Induced Emission‐Active Macrocycle: Illusory Topology of the Penrose Stairs
Authors: He Zikai , Wang Erjing , Lam Jacky W. Y. , Li Yang , Lin Zhenyang , Tang Ben Zhong 
Published: June 2015

AbstractThe facile synthesis of a tetraphenylethene‐based macrocycle having aggregation‐induced emission characteristics and that expresses illusory topology of the Penrose stairs is presented. As a result of the twisted chirality (P or M) of the tetraphenylethene unit and the axial chirality of the macrocyclic linkage (R or S), the macrocycle exhibits two absolute configurations whose interconversion is energetically favorable as revealed by theoretical calculations.
Catalytic Production of Branched Small Alkanes from Biohydrocarbons
Authors: Oya Shin‐ichi , Kanno Daisuke , Watanabe Hideo , Tamura Masazumi , Nakagawa Yoshinao , Tomishige Keiichi 
Published: June 2015

AbstractSqualane, C30 algae‐derived branched hydrocarbon, was successfully converted to smaller hydrocarbons without skeletal isomerization and aromatization over ruthenium on ceria (Ru/CeO2). The internal CH2CH2 bonds located between branches are preferably dissociated to give branched alkanes with very simple distribution as compared with conventional methods using metal‐acid bifunctional catalysts.
Computationally efficient multidimensional analysis of complex flow cytometry data using second order polynomial histograms
Authors: Zaunders John , Jing Junmei , Leipold Michael , Maecker Holden , Kelleher Anthony D. , Koch Inge 
Published: June 2015

AbstractMany methods have been described for automated clustering analysis of complex flow cytometry data, but so far the goal to efficiently estimate multivariate densities and their modes for a moderate number of dimensions and potentially millions of data points has not been attained. We have devised a novel approach to describing modes using second order polynomial histogram estimators (SOPHE). The method divides the data into multivariate bins and determines the shape of the data in each bin based on second order polynomials, which is an efficient computation. These calculations yield local maxima and allow joining of adjacent bins to identify clusters. The use of second order polynomials also optimally uses wide bins, such that in most cases each parameter (dimension) need only be divided into 4–8 bins, again reducing computational load. We have validated this method using defined mixtures of up to 17 fluorescent beads in 16 dimensions, correctly identifying all populations in data files of 100,000 beads in <10 s, on a standard laptop. The method also correctly clustered granulocytes, lymphocytes, including standard T, B, and NK cell subsets, and monocytes in 9‐color stained peripheral blood, within seconds. SOPHE successfully clustered up to 36 subsets of memory CD4 T cells using differentiation and trafficking markers, in 14‐color flow analysis, and up to 65 subpopulations of PBMC in 33‐dimensional CyTOF data, showing its usefulness in discovery research. SOPHE has the potential to greatly increase efficiency of analysing complex mixtures of cells in higher dimensions. © 2015 International Society for Advancement of Cytometry
Developmental nicotine exposure enhances inhibitory synaptic transmission in motor neurons and interneurons critical for normal breathing
Authors: Jaiswal Stuti J. , Buls Wollman Lila , Harrison Caitlyn M. , Pilarski Jason Q. , Fregosi Ralph F. 
Published: June 2015

ABSTRACTNicotine exposure in utero negatively affects neuronal growth, differentiation, and synaptogenesis. We used rhythmic brainstems slices and immunohistochemistry to determine how developmental nicotine exposure (DNE) alters inhibitory neurotransmission in two regions essential to normal breathing, the hypoglossal motor nucleus (XIIn), and preBötzinger complex (preBötC). We microinjected glycine or muscimol (GABAA agonist) into the XIIn or preBötC of rhythmic brainstem slices from neonatal rats while recording from XII nerve roots to obtain XII motoneuron population activity. Injection of glycine or muscimol into the XIIn reduced XII nerve burst amplitude, while injection into the preBötC altered nerve burst frequency. These responses were exaggerated in preparations from DNE animals. Quantitative immunohistochemistry revealed a significantly higher GABAA receptor density on XII motoneurons from DNE pups. There were no differences in GABAA receptor density in the preBötC, and there were no differences in glycine receptor expression in either region. Nicotine, in the absence of other chemicals in tobacco smoke, alters normal development of brainstem circuits that are critical for normal breathing. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 337–354, 2016
Detection of silent cells, synchronization and modulatory activity in developing cellular networks
Authors: Hjorth Johannes J.J. , Dawitz Julia , Kroon Tim , Pires Johny , Dassen Valerie J. , Berkhout Janna A. , Emperador Melero Javier , Nadadhur Aish G. , Alevra Mihai , Toonen Ruud F. , Heine Vivi M. , Mansvelder Huibert D. , Meredith Rhiannon M. 
Published: June 2015

ABSTRACTDeveloping networks in the immature nervous system and in cellular cultures are characterized by waves of synchronous activity in restricted clusters of cells. Synchronized activity in immature networks is proposed to regulate many different developmental processes, from neuron growth and cell migration, to the refinement of synapses, topographic maps, and the mature composition of ion channels. These emergent activity patterns are not present in all cells simultaneously within the network and more immature “silent” cells, potentially correlated with the presence of silent synapses, are prominent in different networks during early developmental periods. Many current network analyses for detection of synchronous cellular activity utilize activity‐based pixel correlations to identify cellular‐based regions of interest (ROIs) and coincident cell activity. However, using activity‐based correlations, these methods first underestimate or ignore the inactive silent cells within the developing network and second, are difficult to apply within cell‐dense regions commonly found in developing brain networks. In addition, previous methods may ignore ROIs within a network that shows transient activity patterns comprising both inactive and active periods. We developed analysis software to semi‐automatically detect cells within developing neuronal networks that were imaged using calcium‐sensitive reporter dyes. Using an iterative threshold, modulation of activity was tracked within individual cells across the network. The distribution pattern of both inactive and active, including synchronous cells, could be determined based on distance measures to neighboring cells and according to different anatomical layers. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 357–374, 2016
dictyBase 2015: Expanding data and annotations in a new software environment
Authors: Basu Siddhartha , Fey Petra , Jimenez‐Morales David , Dodson Robert J. , Chisholm Rex L. 
Published: June 2015

SummarydictyBase is the model organism database for the social amoeba Dictyostelium discoideum and related species. The primary mission of dictyBase is to provide the biomedical research community with well‐integrated high quality data, and tools that enable original research. Data presented at dictyBase is obtained from sequencing centers, groups performing high throughput experiments such as large‐scale mutagenesis studies, and RNAseq data, as well as a growing number of manually added functional gene annotations from the published literature, including Gene Ontology, strain, and phenotype annotations. Through the Dicty Stock Center we provide the community with an impressive amount of annotated strains and plasmids. Recently, dictyBase accomplished a major overhaul to adapt an outdated infrastructure to the current technological advances, thus facilitating the implementation of innovative tools and comparative genomics. It also provides new strategies for high quality annotations that enable bench researchers to benefit from the rapidly increasing volume of available data. dictyBase is highly responsive to its users needs, building a successful relationship that capitalizes on the vast efforts of the Dictyostelium research community. dictyBase has become the trusted data resource for Dictyostelium investigators, other investigators or organizations seeking information about Dictyostelium, as well as educators who use this model system. genesis 53:523–534, 2015. © 2015 Wiley Periodicals, Inc.
Pd‐Catalyzed Hydrogen‐Transfer Reactions from Alcohols to C=C, C=O, and C=N Bonds
Authors: Muzart Jacques 
Published: June 2015

AbstractThis review covers Pd‐catalyzed abstracting and borrowing hydrogen transfers from alcohols to C=C, C=O, and C=N bonds. An abstracting hydrogen transfer implies a reaction in which an alcohol serves only as a hydrogen atom source, whereas in a borrowing hydrogen transfer the alcohol is part of the final product. Both transfer types involve a palladium monohydride or palladium dihydride, and are implicated in a variety of useful and safe one‐pot reactions such as the formation, with low quantities of waste material, of C–C, C–O, and C–N bonds. Plausible mechanisms are, as far as possible, provided.
A One‐Pot Synthesis of Triazolodiazepines
Authors: Hooyberghs Geert , Van Hove Sofie , Jacobs Jeroen , Van Meervelt Luc , Van der Eycken Erik V. 
Published: June 2015

AbstractA one‐pot sequential A3‐coupling‐azidation‐cyclisation approach leading to potentially biologically active diazepine analogues has been developed. The implementation of the A3‐coupling reaction ensures diversity. Attention is given to this so far rarely studied structural motif of fused heterocyclic diazepines.
Prisms for pain. Can visuo‐motor rehabilitation strategies alleviate chronic pain?
Authors: Torta D.M. , Legrain V. , Rossetti Y. , Mouraux A. 
Published: June 2015

AbstractBackground and aimsPrism adaptation (PA) is a non‐invasive procedure in which participants perform a visuo‐motor pointing task while wearing prism goggles inducing a lateral displacement of the visual field and a mismatch between the seen and felt position of the pointing hand. PA is thought to induce a reorganization of sensorimotor coordination, and has been used successfully to rehabilitate neglect following right‐hemisphere lesions. Because studies have shown that complex regional pain syndrome (CRPS) is associated with neglect‐like symptoms, it was proposed that PA could be used to alleviate pain in these patients.DatabaseA search for peer‐reviewed articles on neglect‐like symptoms in CRPS and on the use of prisms in CRPS was conducted using the PubMed database.ResultsThere is still no agreement as to whether CRPS patients really present neglect symptoms and, if they do, what it is that they neglect. Furthermore, there is insufficient data to determine whether PA exerts an effect on CRPS symptoms. Finally, it remains unknown whether neglect can be observed in other types of lateralized pain, or whether PA could be useful for these patients.ConclusionBy highlighting open issues, our review provides guidelines for future studies on the use of prisms in pain. The assessment of neglect in patients with CRPS as well as other types of lateralized chronic pain should be characterized using a combination of neuropsychological methods assessing the multiple aspects of neglect in a more refined manner. In addition, further studies should investigate the mechanisms through which PA may modulate pain.
I need you closer to me: Effects of affiliation goals on perceptions of interpersonal distance
Authors: Stel Mariëlle , van Koningsbruggen Guido M. 
Published: June 2015

AbstractPeople's perceptions are often distorted in a way that aligns with their desires and goals. We argue that having a goal to affiliate changes the perception of interpersonal distance in a way that may help to fulfil this affiliation goal. As other people are goal‐relevant when having an affiliation goal, we expected that people with affiliation goals would estimate the distance between themselves and another person as smaller than people with no affiliation goals. In two studies, we manipulated affiliation goals by priming participants with affiliation or control words. Our main dependent variable was the estimated interpersonal distance between themselves and the experimenter. Results showed that participants primed with affiliation estimated the interpersonal distance as smaller compared with participants primed with control words. We did not obtain reliable differences between the affiliation and control conditions on other distance and height estimations. Our results suggest that having or not having affiliation goals influences people's perception of the distance between them and other people.
Assessment of accumulation rates in small reservoirs by core analysis, 137Cs measurements and bathymetric mapping in Burkina Faso
Authors: Schmengler Almut C. , Vlek Paul L.G. 
Published: June 2015

AbstractReservoir siltation is one of the most important off‐site effects of soil erosion. In Burkina Faso a large number of small dams have been built to store rainfall and runoff water in the rainy season, which is much needed for domestic use, irrigation and stock watering in the dry season. This study quantifies the siltation rates of two small reservoirs in southwestern Burkina Faso by comparing the initial and current reservoir bed morphology and by analyzing variations in accumulated sediment in terms of stratigraphical changes and 137Cs concentrations. Results of a bathymetric survey show that both reservoirs have already lost approximately 10% to 15% of their original storage capacity at normal pool level and more than 60% of their initial inactive storage volume at spillway level in the last 15 to 20 years. During this period, inflow sediment had accumulated on the bottom of the reservoir to a thickness of 0.3 m to 0.5 m. Sediment core measurements confirmed this thickness by showing a clear stratigraphical change in core properties with significant variations in the 137Cs concentrations at these specific depths. The thickness of accumulated sediment on top of the relict soil indicates that the reservoirs have a ‘half‐life’ of about 40 to 45 years before siltation might affect its water supply and flood control. Compared with other reservoir studies in West Africa these siltation rates can be seen as reasonable but not alarmingly high. Nevertheless, many of the small dams built during the 1980s are likely to reach their ‘half‐life’ in about 10 to 20 years causing hydrological and geomorphological changes upstream and downstream of the dams. Therefore, further research studies should focus on prevention measures to reduce the off‐site effects of erosion and thus to slow down the process of siltation. Copyright © 2015 John Wiley & Sons, Ltd.
Influence of in ovo mercury exposure, lake acidity, and other factors on common loon egg and chick quality in Wisconsin
Authors: Kenow Kevin P. , Meyer Michael W. , Rossmann Ronald , Gray Brian R. , Arts Michael T. 
Published: June 2015

Abstract

A field study was conducted in Wisconsin (USA) to characterize in ovo mercury (Hg) exposure in common loons (Gavia immer). Total Hg mass fractions ranged from 0.17 µg/g to 1.23 µg/g wet weight in eggs collected from nests on lakes representing a wide range of pH (5.0–8.1) and were modeled as a function of maternal loon Hg exposure and egg laying order. Blood total Hg mass fractions in a sample of loon chicks ranged from 0.84 µg/g to 3.86 µg/g wet weight at hatch. Factors other than mercury exposure that may have persistent consequences on development of chicks from eggs collected on low-pH lakes (i.e., egg selenium, calcium, and fatty acid mass fractions) do not seem to be contributing to reported differences in loon chick quality as a function of lake pH. However, it was observed that adult male loons holding territories on neutral-pH lakes were larger on average than those occupying territories on low-pH lakes. Differences in adult body size of common loons holding territories on neutral-versus low-pH lakes may have genetic implications for differences in lake-source-related quality (i.e., size) in chicks. The tendency for high in ovo Hg exposure and smaller adult male size to co-occur in low-pH lakes complicates the interpretation of the relative contributions of each to resulting chick quality. Environ Toxicol Chem 2015;34:1870–1880. © 2015 SETAC
Bioaccumulation, subcellular distribution, and acute effects of chromium in Japanese medaka (Oryzias latipes)
Authors: Li Lixia , Chen Hongxing , Bi Ran , Xie Lingtian 
Published: June 2015

Abstract

Chromium (Cr) is an essential element but is toxic to aquatic organisms at elevated concentrations. In the present study, adult Japanese medaka (Oryzias latipes) were exposed to a sublethal hexavalent chromium (Cr(VI)) concentration via dissolved and dietary exposures for 6 d. Various measurements of Cr were made: bioaccumulation in different tissues, subcellular distribution in the liver, effects on antioxidants and acetylcholinesterase (AChE), and Cr-induced lipid peroxidation. The results showed that bioaccumulation increased dramatically in all tested tissues from dissolved exposure but only significantly in the intestine from dietary treatment, implying that dissolved exposure may be predominant for Cr accumulation in medaka. Subcellular distribution revealed that Cr accumulated in the liver was mainly (46%) associated with the heat-stable protein fraction. Among the antioxidants examined, catalase (CAT) responded to dissolved Cr exposure in most tissues whereas superoxide dismutase (SOD) was less responsive. Malondialdehyde concentrations were significantly elevated in most tissues examined in the dissolved Cr-exposed fish, but were only elevated in the liver and intestine in the dietary Cr-exposed fish. The AChE activity in the brain was stimulated by 49% in the dissolved Cr-exposed fish. Reductions in condition factor and gonadosomatic index were also observed. These data help in an understanding of Cr tissue distribution and the acute effects of Cr in Japanese medaka. Environ Toxicol Chem 2015;34:2611–2617. © 2015 SETAC
Social Space and Field as Constructs for Evaluating Social Inclusion
Authors: Lapidot‐Lefler Noam , Friedman Victor J. , Arieli Daniella , Haj Noha , Sykes Israel , Kais Nasreen 
Published: June 2015

AbstractThis paper addresses the role of evaluation in promoting social inclusion, an important component of social justice, with a focus on exclusion resulting from physical disability. We argue that the evaluation of social exclusion and social inclusion requires evaluators not only to reconsider their role and methods, but also to revise the fundamental constructs through which they study how programs and other interventions generate change at the individual, group, community, and societal levels. Drawing on field theory, we suggest that social inclusion processes can be understood and assessed in terms of the expansion of individuals’ life space, which consists of social, political, cultural, and resource dimensions. The paper illustrates these constructs with data from a participative action evaluation of a pilot program for providing services to people with disabilities in Israel. Our aim in developing these constructs is to provide not only tools for assessment, but also ways of thinking that may enable socially excluded people to be more active agents of inclusion.