bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Compound heterozygous nonsense mutations in TRMT10A are associated with microcephaly, delayed development, and periventricular white matter hyperintensities
Authors: Narayanan Mohan , Ramsey Keri , Grebe Theresa , Schrauwen Isabelle , Szelinger Szabolcs , Huentelman Matthew , Craig David , Narayanan Vinodh ,   C4RCD Research Group
Published: September 2015

Microcephaly is a fairly common feature observed in children with delayed development, defined as head circumference less than 2 standard deviations below the mean for age and gender. It may be the result of an acquired insult to the brain, such prenatal or perinatal brain injury (congenital infection or hypoxic ischemic encephalopathy), or be a part of a genetic syndrome. There are over 1000 conditions listed in OMIM (Online Mendelian Inheritance in Man) where microcephaly is a key finding; many of these are associated with specific somatic features and non-CNS anomalies. The term primary microcephaly is used when microcephaly and delayed development are the primary features, and they are not part of another recognized syndrome.In this case report, we present the clinical features of siblings (brother and sister) with primary microcephaly and delayed development, and subtle dysmorphic features. Both children had brain MRI studies that showed periventricular and subcortical T2/FLAIR hyperintensities, without signs of white matter volume loss, and no parenchymal calcifications by CT scan. The family was enrolled in a research study for whole exome sequencing of probands and parents. Analysis of variants determined that the children were compound heterozygotes for nonsense mutations, c.277C>T (p.Arg93*) and c.397C>T (p.Arg133*), in the TRMT10A gene. Mutations in this gene have only recently been reported in children with microcephaly and early onset diabetes mellitus.Our report adds to current knowledge of TRMT10A related neurodevelopmental disorders and demonstrates imaging findings suggestive of delayed or abnormal myelination of the white matter in this disorder. Accurate diagnosis through genomic testing, as in the children described here, allows for early detection and management of medical complications, such as diabetes mellitus.
Skewness and the Relation Between Risk and Return
Authors: Theodossiou Panayiotis , Savva Christos S. 
Published: September 2015

The relationship between risk and return has been one of the most important and extensively investigated issues in the financial economics literature. The theoretical results predict a positive relation between the two. Nevertheless, the empirical findings so far have been contradictory. Evidence presented in this paper shows that these contradictions are the result of negative skewness in the distribution of portfolio excess return and the fact that the estimation of intertemporal asset pricing models are based on symmetric log-likelihood specifications. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2201 . This paper was accepted by Jerome Detemple, finance.
Investor Sentiment and Timberland Investment Returns
Authors: Yao Wenjing , Cheng Baodong , Mei Bin 
Published: September 2015

Abstract
We use the orthogonalized investor sentiment index formed by M. Baker and J. Wurgler (J. Financ. 61(4):1645–1680, 2006) to examine the relationship between investor sentiment and timberland investment returns. The empirical results show that current investor sentiment is an important factor that determines the one-quarter future returns of timberland investment, and the predicting power persists over the next 1 to 5 years. Both the short- and long-term studies obtain negative coefficients on investor sentiment, indicating that current increase in investor sentiment drives prices up and lowers future returns. In addition, significantly different return variances and insignificantly different average returns of timberland investment are obtained between low- and high-sentiment periods. The result further confirms the ability of earning long-term stable returns by timberland investment.
Injection of botulinum toxin for the treatment of post-laryngectomy pharyngoesophageal spasm-related disorders
Authors: Lightbody KA , Wilkie MD , Kinshuck AJ , Gilmartin E , Lewis-Jones H , Jones TM , Lancaster J 
Published: September 2015

Introduction Pharyngoesophageal spasm (PES) can cause dysphagia, central valve leak (CVL), and dypshonia in post-laryngectomy patients. Botulinum toxin has been used effectively for the treatment of PES, but data regarding patient-reported outcomes and efficacy for CVL are limited. We evaluated the results of botox injection for PES spasm using subjective and objective measures. Methods Data were collected prospectively (February 2010 to August 2013) on 13 patients undergoing botox injection for PES as identified by video fluoroscopy. We collected digital voice recordings, air-pressure measurements (APMs) for speech, and quality of life (QoL) data before and after the procedure: University of Washington QoL questionnaire (UW-QoL), MD Anderson Swallowing Inventory (MDADI) and the Voice Handicap Index (VHI-30). Results APMs for a sustained vowel decreased by 18% after botox injection, whereas maximum phonatory times increased by 63% (mean increase, 8 to 13 seconds). Sustained vowel amplitude decreased (mean, 87db to 83db) with an associated reduction in sustained vowel frequency (117Hz to 77Hz). MDADI scores improved by 10.2% overall, and UW-QoL scores showed an improvement in score of 7.6%. Mean scores for VHI-30 deteriorated by 2% overall but, when considering only those patients experiencing dysphonia, an improvement of 9.4% was seen. There was an overall net reduction for the CVL cohort of 12 speech valves in the year after injection. Conclusions Our series confirm the safety and objective efficacy of botox injection for PES. QoL measurements were less convincing, and this disparity between subjective and objective measurements must be considered when treating such patients.
Effect of an independent-sector treatment centre on provision of elective orthopaedic surgery in east and north hertfordshire
Authors: Vanhegan I , Hakmi A , de Roeck N , Rumian A 
Published: September 2015

Introduction Independent Sector Treatment Centres (ISTCs) were created to relieve pressure from Acute Hospital Trusts. In October 2011, an ISTC opened on the grounds of a hospital within the East and North Hertfordshire NHS Trust. Most elective orthopaedic procedures were transferred there. We investigated the effect on productivity of operating theatres working in the ISTC compared with those working in the Acute Hospital Trust (AHT). Methods A 3-month period of working at the AHT was compared with the same period 9-months later in the ISTC, which were termed ‘pre-’ and ‘post-ISTC’ opening, respectively. Data for upper limb (UL) as well as foot and ankle (F&A) surgery were collected. Differences in the number of lists and patients per list constituted usage analyses. Financial productivity was calculated from the latest Payment by Results (PbR) data. A two-tailed Mann–Whitney U-test at a confidence level of 95% was employed to compare costs between groups. Results The UL surgeon undertook 18 lists in both years with 66 patients (pre-ISTC) and 32 (post-ISTC), eliciting a reduction in productivity of 51.5%. There were 13 lists for F&A surgery pre-ISTC with 67 procedures, and 20 lists with 49 patients post-ISTC. Allowing for the difference in the number of lists, a reduction of 52.5% was noted. PbR analyses confirmed productivity of £169,695 (pre-ISTC) and £95,760 (post-ISTC) at a loss of £73,935 for the UL surgeon. F&A data revealed £97,801 (pre-ISTC) and £91,960 (post-ISTC) at a loss of £54,742 when correcting for the difference in the number of lists. There was a combined reduction in potential financial productivity of £128,677 over 3 months or £514,708 over 1 year. Discussion Implementation of the ISTC was detrimental to departmental efficiency, with <50% of the number of patients being treated and a marked reduction in financial productivity.
The replacement of media policies with (media) entrepreneurship policies: A view from Europe’s periphery
Authors: Ibrus Indrek 
Published: September 2015

Abstract
Estonia is recognized for its optimism with regard to Information and Communication Technologies (ICTs) – the country has benchmarking online services, and the number of start-ups per inhabitant is the highest in Europe. The ways this enthusiasm is translated into its audio-visual policy is the topic of this article. Estonia’s internal market for audio-visual services is very small, and this limits the degrees of freedom for its institutional actors – commercial broadcasters do not drive market innovation. Yet the responsibility of public service broadcasters for innovation coordination is not recognized in Estonia’s policy frameworks. In contrast, many new initiatives are funded that are aimed at supporting the cooperation of the audiovisual industry’s small and medium enterprises (SMEs) with ICT sector. Such initiatives rely on the hope for scalable returns to national gross domestic product (GDP) rather than generating diversity in media. Yet these measures suffer from structural constraints that limit the growth of media SMEs in small peripheral countries. This article raises related issues for both national and European policies.
What the Macedonian phone-tapping scandal tells us about clientelism in the media
Authors: Micevski Igor , Trpevska Snezana 
Published: September 2015

Abstract
We focus on the method of rule of the last Macedonian government led by the rightwing VMRO-DPMNE with respect to (TV) media-political clientelism. An ongoing phone-tapping scandal has made overt what past research has only suggested was taking place – that the new ‘phase’ of the patron-broker-client relationships in the country has suppressed rational legal authority to the extent that it has shaken the very core of state institutions’ legitimacy. Since 2006, a reordered media-political clientelism gradually enabled the emergence of a propagandistic media setting, which in turn facilitated a lack of public resistance to party’s colonization of the state and enabled its move towards an authoritarian fashion of rule. We claim here that in the regime’s manner of rule, the journalists and media professionals played the role of both victims and collaborators.
A new hope? Experiences of accessibility of services in deaf and hard-of-hearing audiences post-digital television switchover
Authors: Evans Leighton , Wu Yan , Price Elain 
Published: September 2015

Abstract
One promise of the switchover from analogue to digital television was new accessibility solutions. In the case of deaf and hard-of-hearing audiences who rely on subtitling for comprehension, the digital switchover makes it possible for greater provision of subtitling or improvements in accuracy. Utilizing quantitative data from a questionnaire completed by 339 participants with varying degrees of hearing difficulty in Wales, this article assesses perceptions of subtitling pre- and postdigital switch. A within-group comparison across age groups is also used to assess whether improvements in service are age defined. The results found that difficulties in accessing quality subtitling are still experienced by this audience post-digital switchover and that there are no significant differences in age in experiencing these difficulties. Knowledge of other digital services is subject to a significant difference in age, which indicates more work is required to inform older audience members of the affordances of digital television.
Fluid mechanics aspects of magnetic drug targeting
Authors: Odenbach Stefan 
Published: September 2015

AbstractExperiments and numerical simulations using a flow phantom for magnetic drug targeting have been undertaken. The flow phantom is a half y-branched tube configuration where the main tube represents an artery from which a tumour-supplying artery, which is simulated by the side branch of the flow phantom, branches off. In the experiments a quantification of the amount of magnetic particles targeted towards the branch by a magnetic field applied via a permanent magnet is achieved by impedance measurement using sensor coils. Measuring the targeting efficiency, i.e. the relative amount of particles targeted to the side branch, for different field configurations one obtains targeting maps which combine the targeting efficiency with the magnetic force densities in characteristic points in the flow phantom. It could be shown that targeting efficiency depends strongly on the magnetic field configuration. A corresponding numerical model has been set up, which allows the simulation of targeting efficiency for variable field configuration. With this simulation good agreement of targeting efficiency with experimental data has been found. Thus, the basis has been laid for future calculations of optimal field configurations in clinical applications of magnetic drug targeting. Moreover, the numerical model allows the variation of additional parameters of the drug targeting process and thus an estimation of the influence, e.g. of the fluid properties on the targeting efficiency. Corresponding calculations have shown that the non-Newtonian behaviour of the fluid will significantly influence the targeting process, an aspect which has to be taken into account, especially recalling the fact that the viscosity of magnetic suspensions depends strongly on the magnetic field strength and the mechanical load.
2-Amino-4-arylthiazole Derivatives as
Anti-giardial Agents: Synthesis,
Biological Evaluation and QSAR Studies
Authors: Mocelo-Castell Raul , Villanueva-Novelo Carlos , Cáceres-Castillo David , Carballo Ruben M. , Quijano-Quiñones Ramiro F. , Quesadas-Rojas Mariana , Cantillo-Ciau Zulema , Cedillo-Rivera Roberto , Moo-Puc Rosa E. , Moujir Laila M. , Mena-Rejón Gonzalo J. 
Published: September 2015

Abstract
A series of seven 2-amino-4-arylthiazoles were prepared following Hantzsch’s modified method under microwave irradiation. A set of 50 derivatives was obtained and the in vitro activity against Giardia intestinalis was evaluated. The results on the biological activity revealed that, in general, the N-(5-bromo-4-aryl-thiazol-2-yl)-acetamide scaffold showed high bioactivity. In particular, compounds 6e (IC50 = 0.39 μM) and 6b (IC50 = 0.87 μM) were found to be more potent than the positive control metronidazole. Citoxicity and acute toxicity tests performed showed low toxicity and high selectivity of the most active compounds (6e SI = 139, 6b SI = 52.3). A QSAR analysis was applied to a data set of 37 obtained 2-amino-4-arylthiazoles derivatives and the best model described a strongly correlation between the anti-giardiasic activity and molecular descriptors as E2M, RDF115m, F10, MATS6v, and Hypnotic-80, with high statistical quality. This finding indicates that N-substituted aminothiazole scaffold should be investigated for the development of highly selective anti-giardial agent.
Simultaneous determination of 223 pesticides in tobacco by GC with simultaneous electron capture and nitrogen-phosphorous detection and mass spectrometric confirmation
Authors: Lozowicka Bozena , Rutkowska Ewa , Hrynko Izabela 
Published: September 2015

Abstract
LSE (liquid-solid extraction), MSPD (matrix solid phase dispersion) and QuEChERS (quick, easy, cheap, effective, rugged and safe) extractions followed by GC-μECD/NPD to determine 223 pesticide residues in tobacco simultaneously were developed and compared. The identities of ten model pesticides were confirmed by GC-MS/MS. The type and amount of dispersant (Florisil, silica gel and alumina), sample mass, cleanup adsorbent, and the eluent (hexane, acetone and acetonitrile) were optimized. Linearity, recovery, LOQ, LOD, and matrix effect were compared. Most recoveries were 71−120% (RSD < 18%). LOD and LOQ were much lower than the CORESTA GRLs. The best method was QuEChERS: acetonitrile extraction and dispersive solid-phase extraction using primary-secondary amine and graphitized carbon.
On the Numerical Solution of Some Non-Linear Stochastic Differential Equations Using the Semi-Discrete Method
Authors: Halidias Nikolaos , Stamatiou Ioannis S. 
Published: September 2015

Abstract
We are interested in the numerical solution of
stochastic differential equations with non-negative solutions. Our
goal is to construct explicit numerical schemes that preserve
positivity, even for super-linear stochastic differential equations.
It is well known that the usual Euler scheme diverges on super-linear problems and
the tamed Euler method does not preserve positivity. In that
direction, we use the semi-discrete method that the first author has proposed in
two previous papers. We propose a new numerical scheme for a class of stochastic differential equations
which are super-linear with non-negative solution. The Heston 3/2-model appearing in financial mathematics belongs to this class of stochastic differential equations. For this model we prove, through numerical experiments, the “optimal” order of strong convergence at least 1/2 of the semi-discrete method.
A class of zero divisor rings in which every graph is precisely the union of a complete graph and a complete bipartite graph
Authors: Nauman Syed Khalid , Shafee Basmah H. 
Published: September 2015

Abstract
Recently, an interest is developed in estimating genus of the zero-divisor graph of a ring. In this note we investigate genera of graphs of a class of zero-divisor rings (a ring in which every element is a zero divisor). We call a ring R to be right absorbing if for a; b in R, ab is not 0, then ab D a. We first show that right absorbing rings are generalized right Klein 4-rings of characteristic two and that these are non-commutative zero-divisor local rings. The zero-divisor graph of such a ring is proved to be precisely the union of a complete graph and a complete bipartite graph. Finally, we have estimated lower and upper bounds of the genus of such a ring.
A finite difference method for fractional
diffusion equations with Neumann boundary
conditions
Authors: Szekeres Béla J. , Izsák Ferenc 
Published: September 2015

Abstract
A finite difference numerical method is investigated for fractional order diffusion problems in one space
dimension. The basis of the mathematical model and the numerical approximation is an appropriate extension of
the initial values, which incorporates homogeneous Dirichlet or Neumann type boundary conditions. The wellposedness
of the obtained initial value problem is proved and it is pointed out that each extension is compatible with
the original boundary conditions. Accordingly, a finite difference scheme is constructed for the Neumann problem
using the shifted Grünwald–Letnikov approximation of the fractional order derivatives, which is based on infinite
many basis points. The corresponding matrix is expressed in a closed form and the convergence of an appropriate
implicit Euler scheme is proved.
Die Kristallstruktur von bis-Cyclooctadien-(1,5)-Nickel(0)
Authors: Diebks Hinbich , Dietrich Hans 
Published: September 2015

Abstract
The crystal structure of bis-cyclo-octadien-nickel, Ni(C8H12)2, has been determined from x-ray diffraction data. The space group is ΡI-C1
i and the unit cell, with a = 10.84, 6 = 9.12, c = 7.38 Å, α = 109.95°, β = 84.72°, γ - 108.13°, contains two molecules, each of which has the symmetry 222. The four C-C double bonds of each molecule are elongated by 0.05 Å compared to normal double bonds and form a quasi-tetrahedral arrangement around the nickel atom with the distances Ni-C all equal to 2.12 Å.
Beziehungen zwischen den Strukturen der Modifikationen des Platin- und Kupferphthalocyanins und einiger Chlorderivate
Authors: Honigmann Bertold , Lenné Horst-Udo , Schrodel Rudolf 
Published: September 2015

Abstract
The instable modifications αI and α II (previously called γ) of copper phthalocyanine are isomorphoua with the stable modifications α I of 4-monochloro-copper phthalocyanine, and α of platinum phthalocyanine respectively. The latter two can be obtained as single crystals and we have determined the essential structural features of them.
By isomorphy considerations it was possible to recognize the structural differences between the β, α I and a II modifications of copper phthalocyanine. These α-structures are very similar to those of the αΠ modification of 4-monochloro phthalocyanine and of the α modification of 4-tetrachloro phthalocyanine.
The essential difference between the α structures and the well-known β structure of copper phthalocyanine is a different type of one-dimensional molecular stacking. There are several ways of assembling the stacks into a space lattice so that different α structures are yielded.
The substitution of peripheral hydrogen by chlorine (in the 4 position) increases the tendency to form α-type stacks and their stabilization.
The formation of a spinel and a hexagonal ferrite by the thermal transformation of cronstedtite
Authors: Steadman R. , Toy M. 
Published: September 2015

Auszug
Kristalle von Cronstedtit Fe2+
3(F3+Si)O4(OH)5 wurden bis 745°C an der Luft erhitzt und ihre Strukturänderungen röntgenographisch untersucht. Von vier beobachteten polymorphen Formen gehen zwei in hexagonale Ferrite und eine in einen Spinell bei 715°C über; die vierte ergibt keine wohldefinierte Struktur.
Bei 275 °C bildet sich zunächst ein Ferri-Cronstedtit, dessen Struktur der der Ausgangsform ähnlich ist. Zwischen 275° und 715 °C wird die Anionverteilung allmählich zu einer dichtesten Kugelpackung; gleichzeitig bilden sich Zonen, ähnlich den Guinier-Preston-Zonen, die kohärent mit dem Ausgangskristall sind. Die Anzahl der Zonen nimmt während des Erhitzens zu; zwischen 650 °C und 715°C geht das ganze in die Spinell- oder Ferritetruktur über. Die Zonen sind im Gegensatz zum Endprodukt nicht ferrimagnetisch.
Der Umwandlungsmechanismus wird dem der Kaolinit-Mullit-Beihen gegenübergestellt.
El accidente de Chernóbil
Authors: Suárez César 
Published: September 2015

El año 2006 nos dejó, entre otras cosas, el XX aniversario del accidente de Chernóbil. Chernóbil es en la actualidad una ciudad fantasma situada al norte de Ucrania, cerca de la frontera con Bielorrusia, después de quedar abandonada por el accidente ocurrido en la central nuclear que llevaba el mismo nombre el 26 de abril de 1986, mientras se experimentaba con el cuarto reactor para comprobar si la energía de las turbinas podía generar suficiente electricidad para las bombas de refrigeración en caso de fallo. Una sucesión de errores provocó una enorme subida de potencia y una gran explosión que dejó al descubierto el núcleo del reactor. Éste emitió una gigantesca nube radiactiva hacia toda Europa. Cómo funcionan los reactores, su comportamiento, una descripción detallada del accidente y sus consecuencias se pueden encontrar en este texto.
Lo local, lo global, lo cotidiano del latino: una mirada a la campaña presidencial de Obama y Clinton
Authors: Del Valle de Villalba María Elena , Portilla Enríquez Jorge 
Published: September 2015

Este trabajo presenta el análisis de un material videográfico que compone la campaña presidencial de Hillary Clinton y Barack Obama dirigida a conquistar el voto latino. A través del método etnográfico (Martínez, 1994) se realiza el análisis de los estereotipos de latino presentados en los videos y se interpreta la descripción de los grupos a los cuales está dirigida la campaña, desde la presentación de lo local, lo cotidiano y la imagen globalizada del latino en dichos videos. Se seleccionaron para este estudio una muestra de dos videos de cada candidato y se procedió a la aplicación de la técnica estudio de caso (Velazco y Díaz, 1997) explicando, desde los aportes de Bourdieu (1990), el papel de los medios en las audiencias actuales para la conformación del mundo social, la percepción de grupos sociales y suposiciones compartidas. Para el análisis del contenido verbal se hace referencia a los trabajos de Ernesto Laclau.