bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coerced consent in clinical research: study protocol for a randomized controlled trial
Authors: Brenna Connor T. A. , Walton Nancy , Cohn Melanie , Siddiqui Urooj , Huszti Ella , Brull Richard 
Published: July 2024

Abstract
Background
Despite the low-risk nature of participation in most clinical anesthesia trials, subject recruitment on the same day as surgery is often restricted due to the concerns of researchers and local research ethics boards that same-day consent may not afford adequate time and opportunity for patients to weigh and make decisions, as well as perceptions of patient vulnerability immediately prior to surgery that could impact the voluntary nature and the rigor of the informed consent process. However, specialties such as anesthesiology, critical care, interventional radiology, and emergency medicine have a varied pattern of practice and patient acquaintance that does not typically afford the luxury of time or, in many cases, advance consent for participation in research. Indeed, the initial encounter between anesthesiologists and patients undergoing elective procedures routinely occurs on the day of surgery. Concerns of coercion related to same-day consent for clinical anesthesia research trials have not been borne out in the literature, and represent a significant obstacle to clinical researchers, as well as to the patients who are denied opportunities for potential benefit through participation in research studies.

Methods
We describe the protocol for a prospective randomized controlled trial examining the voluntariness of patient consent, solicited either in advance of surgery or on the same day, to participate in an anesthesia research study at Women’s College Hospital. One hundred fourteen patients scheduled to undergo ambulatory anterior cruciate ligament repair facilitated by general anesthesia with an adductor canal block will be randomized for recruitment either (a) in the pre-operative assessment clinic before the day of surgery or (b) on the day of surgery, to be approached for consent to participate in a fabricated research study of adjunct medications in adductor canal blocks. Regardless of allocation, patients in both groups will receive the same routine standard of care and will complete a post-operative questionnaire to signal perceptions of undue influence in the process of providing informed consent for the fabricated trial.

Discussion
This study will inform trial design and practice guidelines surrounding the amount of time patients ought to be afforded in order to make durable decisions to participate (or not) in clinical research studies. This is expected to impact trial recruitment in a variety of clinical settings where researchers have only brief opportunities to interface with patients.

Trial registration
The trial was registered prospectively on the Open Science Framework (OSF), registration #46twc, on 2023-Mar-17.
Clinical value of 68Ga-pentixafor PET/CT in patients with primary aldosteronism and bilateral lesions: preliminary results of a single-centre study
Authors: Zuo Rui , Liu Shuang , Li Wenbo , Xia Zhu , Xu Lu , Pang Hua 
Published: July 2024

Abstract
Background
Subtype diagnosis of primary aldosteronism (PA) is used to determine treatment, and the potential utility of 68Ga-pentixafor PET/CT for investigation of PA has long been recognized. The study aimed to evaluate the clinical value of 68Ga-pentixafor PET/CT in the diagnosis and prognosis of patients with bilateral lesions identified by CT.

Methods
In total, 25 patients with PA and bilateral lesions on CT were retrospectively evaluated. All patients underwent 68Ga-Pentixafor PET/CT and adrenal vein sampling. The analysis focused on establishing the relationship between bilateral adrenal lesions SUVmax and the ratio of bilateral adrenal lesions SUVmax (CON) and clinical diagnosis, treatment outcomes, and KCNJ5 gene status.

Results
The concordance rate between 68Ga-Pentixafor PET/CT and adrenal venous sampling was 65.2% (15/23). The lateralization results of 68Ga-pentixafor PET/CT supported the clinical decisions of 20 patients with PA, 90% of whom showed effectiveness in treatment. The SUVmax on the dominant side of the surgically treated patients was higher than that of patients treated with drugs. The SUVmax of the KCNJ5 mutant group was higher than that of the KCNJ5 wild group, and 68Ga-Pentixafor uptake was correlated with KCNJ5 gene status.

Conclusions
68Ga-Pentixafor PET/CT proves beneficial for patients with PA with bilateral lesions on CT. The treatment is generally effective based on the results of PET lateralization. Simultaneously, a certain relationship exists between 68Ga-Pentixafor PET/CT and KCNJ5 gene status, warranting further analysis.
Coptis rhizome extract influence on Streptococcus pneumoniae through autolysin activation
Authors: Lee Eon-Bee , Lee Kyubae 
Published: July 2024

AbstractThis study investigated the antibacterial properties of Coptis rhizome, a plant traditionally used for respiratory infections, against Streptoccus pneumonia (S. pneumoniae), for which there has been minimal empirical evidence of effectiveness. The study particularly examined autolysis, indirectly associated with antibacterial resistance, when using Coptis rhizome for bacterial infections. In our methodology, Coptis rhizome was processed with ethanol and distilled water to produce four different extracts: CRET30, CRET50, CRET70, and CRDW. The antibacterial activity of these extracts were tested through Minimum Inhibitory Concentration (MIC) assays, disk diffusion tests, and time-kill assays, targeting both standard (ATCC 49619) and resistant (ATCC 70067) strains. The study also evaluated the extracts’ biofilm inhibition properties and monitored the expression of the lyt gene, integral to autolysis. The results prominently showed that the CRET70 extract demonstrated remarkable antibacterial strength. It achieved an MIC of 0.125 µg/mL against both tested S. pneumoniae strains. The disk diffusion assay recorded inhibition zones of 22.17 mm for ATCC 49619 and 17.20 mm for ATCC 70067. Impressively, CRET70 resulted in a 2-log decrease in bacterial numbers for both strains, showcasing its potent bactericidal capacity. The extract was also effective in inhibiting 77.40% of biofilm formation. Additionally, the significant overexpression of the lytA gene in the presence of CRET70 pointed to a potential mechanism of action for its antibacterial effects. The outcomes provided new perspectives on the use of Coptis rhizome in combating S. pneumoniae, especially significant in an era of escalating antibiotic resistance.
Recruitment-to-inflation ratio reflects the impact of peep on dynamic lung strain in a highly recruitable model of ARDS
Authors: Murgolo Francesco , Grieco Domenico L. , Spadaro Savino , Bartolomeo Nicola , di Mussi Rossella , Pisani Luigi , Fiorentino Marco , Crovace Alberto Maria , Lacitignola Luca , Staffieri Francesco , Grasso Salvatore 
Published: July 2024

Abstract
Background
The recruitment-to-inflation ratio (R/I) has been recently proposed to bedside assess response to PEEP. The impact of PEEP on ventilator-induced lung injury depends on the extent of dynamic strain reduction. We hypothesized that R/I may reflect the potential for lung recruitment (i.e. recruitability) and, consequently, estimate the impact of PEEP on dynamic lung strain, both assessed through computed tomography scan.

Methods
Fourteen lung-damaged pigs (lipopolysaccharide infusion) underwent ventilation at low (5 cmH2O) and high PEEP (i.e., PEEP generating a plateau pressure of 28–30 cmH2O). R/I was measured through a one-breath derecruitment maneuver from high to low PEEP. PEEP-induced changes in dynamic lung strain, difference in nonaerated lung tissue weight (tissue recruitment) and amount of gas entering previously nonaerated lung units (gas recruitment) were assessed through computed tomography scan. Tissue and gas recruitment were normalized to the weight and gas volume of previously ventilated lung areas at low PEEP (normalized-tissue recruitment and normalized-gas recruitment, respectively).

Results
Between high (median [interquartile range] 20 cmH2O [18–21]) and low PEEP, median R/I was 1.08 [0.88–1.82], indicating high lung recruitability. Compared to low PEEP, tissue and gas recruitment at high PEEP were 246 g [182–288] and 385 ml [318–668], respectively. R/I was linearly related to normalized-gas recruitment (r = 0.90; [95% CI 0.71 to 0.97) and normalized-tissue recruitment (r = 0.69; [95% CI 0.25 to 0.89]). Dynamic lung strain was 0.37 [0.29–0.44] at high PEEP and 0.59 [0.46–0.80] at low PEEP (p < 0.001). R/I was significantly related to PEEP-induced reduction in dynamic (r = − 0.93; [95% CI − 0.78 to − 0.98]) and global lung strain (r = − 0.57; [95% CI − 0.05 to − 0.84]). No correlation was found between R/I and and PEEP-induced changes in static lung strain (r = 0.34; [95% CI − 0.23 to 0.74]).

Conclusions
In a highly recruitable ARDS model, R/I reflects the potential for lung recruitment and well estimates the extent of PEEP-induced reduction in dynamic lung strain.
Upper bound for the second and third Hankel determinants of analytic functions associated with the error function and q-convolution combination
Authors: Srivastava Hari M. , Breaz Daniel , Alburaikan Alhanouf , El-Deeb Sheza M. 
Published: July 2024

AbstractRecently, El-Deeb and Cotîrlă (Mathematics 11:11234834, 2023) used the error function together with a q-convolution to introduce a new operator. By means of this operator the following class $\mathcal{R}_{\alpha ,\Upsilon}^{\lambda ,q}(\delta ,\eta )$

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, we give upper bounds for the Fekete–Szegö functional and for the second and third Hankel determinants.
Reactions of adolescent cyber bystanders toward different victims of cyberbullying: the role of parental rearing behaviors
Authors: Chen Qiqi 
Published: July 2024

Abstract
Background
Group-based situations are common settings for cyberbullying, making bystander responses crucial in combating this issue. This study investigated how adolescent bystanders respond to various victims, including family members, friends, teachers, and celebrities. This study also examined how different parenting styles influenced children’s cyber bystander involvement.

Methods
This study employed data from a cross-sectional school survey covering 1,716 adolescents aged 13–18 years from public and vocational schools in China collected in 2022. Logistic regression analyses were conducted to measure demographic characteristics, cyberbullying experiences, and parental rearing behaviors in predicting bystander reactions.

Results
The findings showed that middle school students preferred to “ask for help” while high school students tended to choose “call the police” when witnessing cyberbullying incidents. Bystanders growing up with parental rejection and overprotection, having previous cyberbullying victimization experiences, where the victims were disliked by them, exhibited fewer defensive reactions.

Conclusions
This study has implications for future research and practices involving parental involvement in cyber bystander interventions, which could provide implications for future practice in designing specific intervention programs for cyberbullying bystander behavior. Future research and interventions against cyberbullying may provide individualized training including parents’ positive parenting skills and parent-child interactions.
Research on intelligent monitoring technology for roof damage of traditional Chinese residential buildings based on improved YOLOv8: taking ancient villages in southern Fujian as an example
Authors: Qiu Haochen , Zhang Jiahao , Zhuo Lingchen , Xiao Qi , Chen Zhihong , Tian Hua 
Published: July 2024

Abstract
In the process of preserving historical buildings in southern Fujian, China, it is crucial to provide timely and accurate statistical data to classify the damage of traditional buildings. In this study, a method based on the improved YOLOv8 neural network is proposed to select aerial photographs of six villages in Xiamen and Quanzhou cities in Fujian Province as the dataset, which contains a total of 3124 photographs. Based on the high-resolution orthophotographs obtained from UAV tilt photography, the YOLOv8 model was used to make predictions. The main task in the first stage is to select the buildings with historical value in the area, and the model's mAP (Mean Accuracy Rate) can reach 97.2% in the first stage task. The second stage uses the YOLOv8 model to segment the images selected in the first stage, detecting possible defects on the roofs, including collapses, missing tiles, unsuitable architectural additions, and vegetation encroachment. In the second stage of the segmentation task, the mAP reaches 89.4%, which is a 1.5% improvement in mAP50 (mean accuracy) compared to the original YOLOv8 model, and the number of parameters and GFLOPs are reduced by 22% and 15%, respectively. This method can effectively improve the disease detection efficiency of historical built heritage in southern Fujian under complex terrain and ground conditions.
Integrated transcriptome and metabolome analysis reveals the molecular responses of Pardosa pseudoannulata to hypoxic environments
Authors: Li Jinjin , Tang Yun-e , Lv Bo , Wang Juan , Wang Zhi , Song Qisheng 
Published: July 2024

AbstractTerrestrial organisms are likely to face hypoxic stress during natural disasters such as floods or landslides, which can lead to inevitable hypoxic conditions for those commonly residing within soil. Pardosa pseudoannulata often inhabits soil crevices and has been extensively studied, yet research on its response to hypoxic stress remains unclear. Therefore, we investigated the adaptive strategies of Pardosa pseudoannulata under hypoxic stress using metabolomics and transcriptomics approaches. The results indicated that under hypoxic stress, metabolites related to energy and antioxidants such as ATP, D-glucose 6-phosphate, flavin adenine dinucleotide (FAD), and reduced L-glutathione were significantly differentially expressed. Pathways such as the citric acid (TCA) cycle and oxidative phosphorylation were significantly enriched. Transcriptome analysis and related assessments also revealed a significant enrichment of pathways associated with energy metabolism, suggesting that Pardosa pseudoannulata primarily copes with hypoxic environments by modulating energy metabolism and antioxidant-related substances.
Application of QPSO-BPSO in fault self-healing of distributed power distribution networks
Authors: Liu Xuan , Liu Meng , Yin Hong 
Published: July 2024

AbstractWith the widespread application of distributed power sources in distribution networks, fault self-healing technology has become the key to ensuring the reliability of power systems. The micro-grid ensures system stability with a three-layer structure, where the designed method handles optimization problems, achieving faster global search and optimal solutions. Agents develop targeted recovery strategies by understanding network load, which are then executed by higher-level agents to ensure that the optimal recovery command is implemented by the system. According to the research results, during peak load, the system successfully outputted 7 kilowatts and met the load demand through battery discharge, demonstrating its self-healing ability. The output analysis of photovoltaic and wind turbines showed that the system reasonably scheduled within 24 h according to the changes in solar energy and wind power. Based on the quantum behavior particle swarm optimization algorithm, the system has achieved lower active power loss and greater power supply capacity. Although the number of switch operations has increased, the system performance has significantly improved, meeting the requirements for improving system economy and safety. It has promoting effects on the sustainable development of future power systems.
Patients’ and caregivers’ perception of multidimensional and palliative care in amyotrophic lateral sclerosis – protocol of a German multicentre study
Authors: Linse Katharina , Weber Constanze , Reilich Peter , Schöberl Florian , Boentert Matthias , Petri Susanne , Rödiger Annekathrin , Posa Andreas , Otto Markus , Wolf Joachim , Zeller Daniel , Brunkhorst Robert , Koch Jan , Hermann Andreas , Großkreutz Julian , Schröter Carsten , Groß Martin , Lingor Paul , Machetanz Gerrit , Semmler Luisa , Dorst Johannes , Lulé Dorothée , Ludolph Albert , Meyer Thomas , Maier André , Metelmann Moritz , Regensburger Martin , Winkler Jürgen , Schrank Berthold , Kohl Zacharias , Hagenacker Tim , Brakemeier Svenja , Weyen Ute , Weiler Markus , Lorenzl Stefan , Bublitz Sarah , Weydt Patrick , Grehl Torsten , Kotterba Sylvia , Lapp Hanna-Sophie , Freigang Maren , Vidovic Maximilian , Aust Elisa , Günther René 
Published: July 2024

Abstract
Introduction
Amyotrophic lateral sclerosis (ALS) is an inevitably fatal condition that leads to a progressive loss of physical functioning, which results in a high psychosocial burden and organizational challenges related to medical care. Multidimensional and multiprofessional care is advised to meet the complex needs of patients and their families. Many healthcare systems, including Germany, may not be able to meet these needs because non-medical services such as psychological support or social counselling are not regularly included in the care of patients with ALS (pwALS). Specialised neuropalliative care is not routinely implemented nor widely available. Caregivers of pwALS are also highly burdened, but there is still a lack of support services for them.

Methods
This project aims to assess the perceptions and satisfaction with ALS care in Germany in pwALS and their caregivers. This will be achieved by means of a cross-sectional, multicentre survey. The examination will assess, to which extend the patients’ needs in the six domains of physical, psychological, social, spiritual, practical and informational are being met by current care structures. This assessment will be linked to mental well-being, subjective quality of life, attitudes toward life-sustaining measures and physician-assisted suicide, and caregiver burden. The study aims to recruit 500 participants from nationwide ALS centres in order to draw comprehensive conclusions for Germany. A total of 29 centres, mostly acquired via the clinical and scientific German Network for Motor Neuron Diseases (MND-NET), will take part in the project, 25 of which have already started recruitment.

Perspective
It is intended to provide data-based starting points on how current practice of care in Germany is perceived pwALS and their caregivers and how it can be improved according to their needs. Planning and initiation of the study has been completed.

Trial registration
The study is registered at ClinicalTrails.gov; NCT06418646
Cytological and ultrastructural investigation of pathogen infection pathway and host responses in asparagus stem infected by Phomopsis asparagi
Authors: Sun Liping , Li Yange , Li Xiaoting , Ruan Xinyi , Zhao Yueyan , Wen Ruidong , Wei Shuaijie , Chen Ning , Zhang Yulan , Li Shufen , Gao Wujun 
Published: July 2024

AbstractAsparagus stem blight, a highly destructive disease in global asparagus cultivation, is caused by the fungus Phomopsis asparagi. However, the underlying mechanisms of the infectious process and pathogenesis of P. asparagi remain poorly understood. This study aims to elucidate the infection event of P. asparagi at the cytological and ultrastructural levels in asparagus stem through a microscopic observation. The host responses were also examined by microscopic observation and fluorescent probe. It revealed that P. asparagi germinated at either the tip or the middle of the conidia to produce short germ tubes on the surfaces of the asparagus stem at 20 h post-inoculation (hpi). The germ tubes penetrated the host cell wall with appressorium-like structures or narrow pegs at 1 day post-inoculation (dpi). At 3 − 5 dpi, a large number of P. asparagi hyphae colonized the epidermal cells. The hyphae were found to grow both intracellularly and intercellularly. The movement of hyphae between cells was facilitated by constricted invasive hyphae pegs. The hyphae exhibited bidirectional intracellular growth, extending and branching along the inner side of the cell wall within the stem cortex and towards the central cylinder. The fungal colonization resulted in cellular damage in plants, which is characterized by plasmolysis, rupture of the cell wall, and disruption of the cytoplasm. At 11 dpi, the fungi penetrated the parenchyma cells, and the fungal pycnidia were formed. At 13 dpi, the fungi penetrated the stem center parenchyma cell, where the conidia were released. In addition, the host defense response was investigated, which revealed a notably reduced germination rate of conidium, the formation of callose analogs, and the reactive oxygen burst. These findings provide unexpected perspectives on the infection process and host response in P. asparagi-plant interaction.
Symptomatic remission and its associated factors among patients with schizophrenia on risperidone or olanzapine at Amanuel mental specialized hospital, Addis Ababa, Ethiopia
Authors: Beyene Melak Gedamu , Teferra Solomon , Fenta Teferi Gedif 
Published: July 2024

Abstract
Background
Schizophrenia is a debilitating condition that affects 1% of the global population. Understanding the prevalence and the factors predicting schizophrenia remission is crucial for healthcare providers. This study aimed to determine the prevalence of remission and factors affecting the remission. Cross-sectional study was conducted at the Amanuel Mental Specialized Hospital from 3 October, 2022, to 31 August, 2023, and included 271 participants. Remission was measured using Remission in Schizophrenia Working Group (RSWG) symptom severity-based criteria. Data analysis was done using SPSS V.25.

Results
The mean age of participants was 34.2 with standard deviation (SD) of 10.5 years. Most were male (90%), unmarried (63.8%), lived with their relatives (91.9%), and were unemployed (56.5%). Fifty-two percent achieved symptomatic remission. Remission in patients with medication switched to SGAs increased by 1.9 times compared to patients without medication switch (AOR 1.9, 95% CI: 1.1, 1.2). Adherent patients had 2.7 times higher odds of symptomatic remission as compared to non-adherent patients (AOR 2.7, 95% CI: 1.5,4.9), and for each unit increase in body mass index (BMI), the odds of achieving symptomatic remission were increased by 13% (AOR 1.13, 95% CI: 1.04, 1.23). The odds of symptomatic remission decreased by 71% in patients experiencing moderate-to-severe side effects compared to their counterparts (AOR 0.29, 95% CI: 0.1, 0.6).

Conclusions
Our study revealed a symptomatic remission was achieved in 141 (52%) of the subjects. There is a possibility to improve symptomatic remission with counseling on the importance of adherence, monitoring and managing side effects, and switching medication to either risperidone or olanzapine. Measuring remission using RSWG time-based criteria is recommended.