bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Review of Soft Tissue Alterations and Esthetic Outcomes Following Immediate Implant Placement and Restoration of Single Implants in the Anterior Maxilla
Authors: Khzam Nabil , Arora Himanshu , Kim Paul , Fisher Anthony , Mattheos Nikos , Ivanovski Saso 
Published: August 2015

Background: The aim of this review is to assess the outcome of single‐tooth immediate implant placement and restoration (IPR) in the maxillary anterior region, with a particular emphasis on soft tissue and esthetic outcomes.Methods: An electronic search in Medline, EBSCOhost, and Ovid (PubMed) was performed to identify studies that reported on soft tissue outcomes following immediate placement and restoration of implants in the maxillary esthetic region with a mean follow‐up of ≥1 year.Results: Nineteen studies on single implants inserted immediately into fresh extraction sockets and provisionally restored in the maxillary esthetic region were included. Soft tissue changes were found to be acceptable, with most studies reporting mean gingival recession of 0.27 ± 0.38 mm and mean papillary height loss of 0.23 ± 0.27 mm after follow‐up of ≥1 year. Advanced buccal recession (>1 mm) occurred in 11% of cases. Long‐term follow‐up studies (>2 years) reported that the interdental papillae, in particular, showed a tendency to rebound over time. The few studies that reported on patient‐centered outcomes showed a high level of patient satisfaction with the outcomes of IPR treatment.Conclusions: The IPR protocol resulted in generally acceptable soft tissue and esthetic outcomes, with suboptimal results reported in ≈11% of low‐risk cases. Factors such as preoperative tissue biotype or use of a flap or connective tissue graft did not significantly influence soft tissue and esthetic outcomes. Long‐term prospective controlled clinical trials are necessary to identify factors that may influence the esthetic outcomes associated with IPR.
Salivary Lipid Peroxidation in Patients With Generalized Chronic Periodontitis and Acute Coronary Syndrome
Authors: Nguyen Thuy T. , Ngo Lan Q. , Promsudthi Ananya , Surarit Rudee 
Published: August 2015

Background: Lipid peroxidation is a major consequence of oxidative stress and can be evaluated via malondialdehyde (MDA) levels. The present study aims to assess MDA levels in the saliva of patients with chronic periodontitis (CP) and acute coronary syndrome (ACS) and establish their correlation with periodontal clinical parameters, serum high‐sensitivity C‐reactive protein (hsCRP), and plasma fibrinogen.Methods: The study enrolled 64 patients stratified into four age‐ and sex‐matched groups: both ACS and CP, ACS only, CP only, and healthy controls. All patients were examined, periodontal clinical parameters were recorded, and saliva and blood samples were collected. Salivary MDA levels were measured using a spectrophotometric assay. A quantitative turbidimetric test was used for the measurement of serum hsCRP levels, and plasma fibrinogen levels were determined using an automated analyzer.Results: Salivary MDA levels were significantly higher in patients with both ACS and CP than in those with only ACS or only CP and healthy controls (P <0.05). There were significant positive correlations between salivary MDA levels and periodontal clinical parameters as well as biomarkers for cardiovascular events (P <0.001).Conclusions: To our knowledge, this study is the first to investigate salivary MDA levels in patients with ACS and their correlations with serum hsCRP and plasma fibrinogen levels. The results indicate that salivary MDA levels could be a biomarker for cardiovascular and/or periodontal disease.
Using Rubrics to Assess Accounting Learning Goal Achievement
Authors: Schaefer Thomas F. , Stevens Jennifer Sustersic 
Published: August 2015

ABSTRACT
This paper illustrates the development and use of rubrics to improve the learning assessment process and enhance the teaching-learning relationship. We highlight the multidimensional benefits of rubrics as valuable tools for student assessment (grading), course assessment (at the instructor level), and program assessment (at the administrator/curriculum committee/accreditation level). Moreover, rubrics may improve qualitative feedback on learning to students and instructors. Development of effective rubrics is framed in terms of learning goals, measurable learning outcomes, choice of assessment vehicle/assignment, and use of data collected from rubrics for feedback and/or improvement. The paper then offers an example set of rubrics designed to assess student achievement of three learning goals common to many undergraduate accounting programs: accounting measurement, research, and critical thinking. This paper may prove useful for instructors looking to use rubrics to improve the teaching-learning process and concurrently evaluate learning goal achievement for course or program assessment. As an auxiliary benefit, the use of scoring rubrics may simplify grading, as well as data collection in documenting assurance of learning for accreditation purposes.
Patient satisfaction after orthodontic treatment combined with orthognathic surgery: A systematic review
Authors: Pachêco-Pereira Camila , Abreu Lucas G. , Dick Bruce D. , De Luca Canto Graziela , Paiva Saul M. , Flores-Mir Carlos 
Published: August 2015

ABSTRACT

Objective:
To synthesize available evidence about factors associated with patients’ satisfaction after orthodontic treatment combined with orthognathic surgery.

Materials and Methods:
Studies that evaluated any factor associated with patients’ satisfaction after the conclusion of an orthodontic treatment combined with an orthognathic surgery were identified. Orthognathic surgical procedures should have been undertaken after completion of craniofacial growth. Any satisfaction psychometric tool was considered. No language limitation was set. A detailed individual search strategy for each of the following bibliographic databases was crafted: MEDLINE, PubMed, EBM Reviews, Web of Science, EMBASE, LILACS, and Scopus. The references cited in the identified articles were also cross-checked, and a partial gray-literature search was undertaken using Google Scholar.

Results:
Eight articles satisfied the inclusion criteria of this systematic review and accounted for 998 patients. The included studies showed large variation in sample size (range  =  44 to 505 patients), age (range  =  15 to 72 years old), distinct psychological evaluation tools, and time elapsed between the assessment and the completion of surgery and postorthodontic treatment. Most of the studies (five of eight) were classified as having high risk of bias.

Conclusion:
Factors associated with satisfaction were final esthetic outcome, perceived social benefits from the outcome, type of orthognathic surgery, sex, and changes in patient self-concept during treatment. Factors associated with dissatisfaction were treatment length; sensation of functional impairment and/or dysfunction after surgery, and perceived omitted information about surgical risks.
Safety and Efficacy of Omarigliptin (MK-3102), a Novel Once-Weekly DPP-4 Inhibitor for the Treatment of Patients With Type 2 Diabetes
Authors: Sheu Wayne H.-H. , Gantz Ira , Chen Menghui , Suryawanshi Shailaja , Mirza Arpana , Goldstein Barry J. , Kaufman Keith D. , Engel Samuel S. 
Published: August 2015

OBJECTIVE
This study was conducted to determine the optimal dose of omarigliptin, a once-weekly (q.w.) dipeptidyl peptidase IV (DPP-4) inhibitor, for the treatment of patients with type 2 diabetes and evaluate the long-term safety of that dose.

RESEARCH DESIGN AND METHODS
In a multicenter, double-blind, 12-week, dose-range finding study, 685 oral antihyperglycemic agent-naïve or washed-out subjects with type 2 diabetes were randomized to one of five once-weekly doses of omarigliptin (0.25 mg, 1 mg, 3 mg, 10 mg, or 25 mg) or placebo. The primary efficacy end point was change from baseline in HbA1c, and secondary end points were 2-h postmeal glucose (PMG) and fasting plasma glucose (FPG). Analysis included all patients who received at least one dose of the study medication. Subjects who completed the base study were eligible to enter a 66-week extension study.

RESULTS
Once-weekly treatment for 12 weeks with omarigliptin provided dose-related reductions in HbA1c, 2-h PMG, and FPG. At week 12, the omarigliptin 25-mg dose provided the greatest glycemic efficacy. The placebo-adjusted least-squares mean reductions from baseline in HbA1c, 2-h PMG, and FPG were −0.72% (−7.8 mmol/mol), −2.5, and −1.3 mmol/L, respectively (all P &lt; 0.001). The incidence of adverse events was similar across dose groups, with a low incidence of symptomatic hypoglycemia and no effect on body weight. Omarigliptin was generally well-tolerated throughout the base and extension studies.

CONCLUSIONS
Omarigliptin 25 mg q.w., compared with placebo, provided significant glucose lowering and was generally well tolerated for up to 78 weeks in patients with type 2 diabetes.
The Presence and Consequence of Nonalbuminuric Chronic Kidney Disease in Patients With Type 1 Diabetes
Authors: Thorn Lena M. , Gordin Daniel , Harjutsalo Valma , Hägg Stefanie , Masar Robert , Saraheimo Markku , Tolonen Nina , Wadén Johan , Groop Per-Henrik , Forsblom Carol M. 
Published: August 2015

OBJECTIVE
This study investigated the prevalence of nonalbuminuric chronic kidney disease in type 1 diabetes to assess whether it increases the risk of cardiovascular and renal outcomes as well as all-cause mortality.

RESEARCH DESIGN AND METHODS
This was an observational follow-up of 3,809 patients with type 1 diabetes from the Finnish Diabetic Nephropathy Study. All patients were Caucasians and thoroughly examined at baseline. Their mean age was 37.6 ± 11.8 years and duration of diabetes 21.2 ± 12.1 years. Follow-up data on cardiovascular and renal outcomes and mortality were retrieved from registers. During 13 years of median follow-up, 378 developed end-stage renal disease, 415 suffered an incident cardiovascular event, and 406 died.

RESULTS
At baseline, 78 (2.0%) had nonalbuminuric chronic kidney disease. This was associated with older age, female sex, history of retinal laser treatment, cardiovascular events, and the number of antihypertensive drugs in use, but not with blood pressure levels or specific antihypertensive agents. Nonalbuminuric chronic kidney disease did not increase the risk of albuminuria (hazard ratio [HR] 2.0 [95% CI 0.9–4.4]) or end-stage renal disease (HR 6.4 [0.8–53.0]) but did increase the risk of cardiovascular events (HR 2.0 [1.4–3.5]) and all-cause mortality (HR 2.4 [1.4–3.9]). The highest risk of cardiovascular and renal end points was observed in the patients with albuminuria.

CONCLUSIONS
Nonalbuminuric chronic kidney disease is not a frequent finding in patients with type 1 diabetes, but when present, it is associated with an increased risk of cardiovascular morbidity and all-cause mortality but not with renal outcomes.
Modelling glacier-bed overdeepenings and possible future lakes for the glaciers in the Himalaya—Karakoram region
Authors: Linsbauer A. , Frey H. , Haeberli W. , Machguth H. , Azam M.F. , Allen S. 
Published: August 2015

AbstractSurface digital elevation models (DEMs) and slope-related estimates of glacier thickness enable modelling of glacier-bed topographies over large ice-covered areas. Due to the erosive power of glaciers, such bed topographies can contain numerous overdeepenings, which when exposed following glacier retreat may fill with water and form new lakes. In this study, the bed overdeepenings for ~28 000 glaciers (40 775 km2) of the Himalaya-Karakoram region are modelled using GlabTop2 (Glacier Bed Topography model version 2), in which ice thickness is inferred from surface slope by parameterizing basal shear stress as a function of elevation range for each glacier. The modelled ice thicknesses are uncertain (±30%), but spatial patterns of ice thickness and bed elevation primarily depend on surface slopes as derived from the DEM and, hence, are more robust. About 16 000 overdeepenings larger than 104m2 were detected in the modelled glacier beds, covering an area of ~2200 km2 and having a volume of ~120km3 (3-4% of present-day glacier volume). About 5000 of these overdeepenings (1800 km2) have a volume larger than 106m3. The results presented here are useful for anticipating landscape evolution and potential future lake formation with associated opportunities (tourism, hydropower) and risks (lake outbursts).
Metastatic male breast cancer
Authors: Sarker MK , Chowdhury PK , Mondal DK 
Published: August 2015

Breast cancer of female is common but rare in male. It is diagnosed in advanced stage due to the limited amount of breast tissue and lack of awareness. Most cases occur over the age of 60 years. Male breast cancer is treated like female breast cancer. The outcome of the disease is worse, 5-4 years survival in about 40% cases.Mediscope Vol. 2, No. 1: 2015, Pages 36-38
Does stronger pollen competition improve offspring fitness when pollen load does not vary?
Authors: Pélabon Christophe , Hennet Lauriane , Bolstad Geir H. , Albertsen Elena , Opedal Øystein H. , Ekrem Runa K. , Armbruster W. Scott 
Published: August 2015

PREMISE OF THE STUDY:Competition among pollen grains from a single donor is expected to increase the quality of the offspring produced because of the recessive deleterious alleles expressed during pollen‐tube growth. However, evidence for such an effect is inconclusive; a large number of studies suffer from confounding variation in pollen competition with variation in pollen load.METHODS:In this study, we tested the effect of pollen competition on offspring performance independently of pollen‐load variation. We compared seed mass and early seedling performance in Dalechampia scandens (Euphorbiaceae) between crosses in which variation in pollen competition was achieved, without variation in pollen load, by manipulating the dispersion of pollen grains on the stigmas.KEY RESULTS:Despite a large sample size (211 crosses on 20 maternal plants), we failed to find an effect of pollen competition on seed characteristics or early seedling performance. Paternal effects were always limited, and pollen competition never reduced the within‐father (residual) variance.CONCLUSION:These results suggest that limited within‐donor variation in genetic quality of pollen grains reduces the potential benefits of pollen competition in the study population. The lack of paternal effects on early sporophyte performance further suggests that benefits of pollen competition among pollen from multiple donors should be limited as well, and it raises questions about the significance of pollen competition as a mechanism of sexual selection.
Yahweh’s ‘lord’ and Unrestrained Evil: An Exegesis of Psalm 110
Authors: Persaud Aran J.E. 
Published: August 2015

This article consists of an exegetical investigation of Psalm 110 and assumes that the psalms function in one sense as prayers, which can be prayed authentically by modern worshippers. Consequently, the specific images of hostile acts of war present a challenge as prayer. The methodology involves the investigation of the text from a grammatico-historical perspective by using selected sources from the 19th century to the present. The meaning of the violent images of enmity and the defining characteristics of the enemy are determined through understanding the perceived suffering of the psalmist. Special attention is given to the role of the phrase םֻאְנָּהוהְי, the identification of יִֹנדַאל and defining the enemy. The conclusions of the exegesis support a more traditional interpretation of יִֹנדַאל and characterise the recalcitrant enemies in an eschatological framework.Jahwe se ‘heer’ en onbeteuelde boosheid: ’n Eksegese van Psalm 110. Hierdie artikel is ’n eksegetiese ondersoek van Psalm 110 en gaan van die veronderstelling uit dat die psalms in ’n sekere sin gebede is wat deur moderne gelowiges gebid kan word. Die spesifieke uitbeeldings van vyandige oorlogsdade stel egter ’n uitdaging aan dié gebed. Die metodologie behels die ondersoek van die teks vanuit ’n grammaties-historiese perspektief deur uitgesoekte bronne vanaf die negentiende eeu tot tans te gebruik. Die betekenis van die geweldadige uitbeelding van vyandigheid en die omskrywende karaktertrekke van die vyand word bepaal deur die verstaan van die waarneembare lyding van die psalmskrywer. Daar word besondere aandag gegee aan die rol van die frase ָהוְהיּםֻאְנ, die eiening van יִֹנדַאל en die omskrywing van die vyand. Die slotsom van die eksegesis ondersteun ’n meer tradisionele interpretasie van יִֹנדַאל en tipeer die onversetlike vyand in ’n eskatalogiese raamwerk.
Complex Coronary Interventions with the Novel Mozec™CTO Balloon: The MOZART Registry
Authors: Lupi Alessandro , Rognoni Andrea , Schaffer Alon , Secco Gioel G. , Bongo Angelo S. 
Published: August 2015

BackgroundMozec™CTO is a novel semicompliant rapid-exchange PTCA balloon catheter with specific features dedicated to treat complex coronary lesions like chronic total occlusions (CTOs). However, no data have been reported about the performance of this device in an all-comers population with complex coronary lesions.MethodsWe evaluated the safety and success rate of Mozec™CTO balloon in 41 consecutive patients with chronic stable angina and complex coronary lesions (15 severe calcified coronary stenoses, 15 bifurcation lesions with planned two-stent intervention, and 11 CTOs). Safety was assessed reporting the balloon burst rate after inflation exceeding the rated burst pressure (RBP) according to the manufacturer's reference table. Success was defined as the possibility to advance the device further the target lesion.ResultsThe Mozec™CTO balloon showed an excellent performance with a 93.3% success in crossing tight and severely calcified lesions (14/15 pts), a 93.3% success in engaging jailed side branches after stent deployment across bifurcations (14/15 pts), and a 90.9% success in crossing CTO lesions (10/11 pts). The burst rate at RBP of the Mozec™CTO balloon was 6.7% (1/15 balloons) in the tight and severely calcified lesions, 6.7% (1/15 balloons) when dilating jailed vessels, and 9.1% (1/11 balloons) in CTOs.ConclusionsThe novel Mozec™CTO balloon dilatation catheter showed promising results when employed to treat complex lesions in an all-comers population. Further studies should clarify if this kind of balloon might reduce the need of more costly devices like over-the-wire balloons and microcatheters for complex lesions treatment.
Standard osteopathic manipulative treatment acutely improves gait performance in patients with Parkinson's disease
Authors: Wells Michael R. , Giantinoto Sal , D’agate David , Areman R D , Fazzini Enrico A , Dowling Dennis , Bosak Andrew 
Published: August 2015

Abstract
Patients with Parkinson's disease exhibit a variety of motor deficits which can ultimately result in complete disability. The primary objective of this study was toquantitatively evaluate the effect of osteopathic manipulative treatment (OMT)on the gait of patients with Parkinson's disease. Ten patients with idiopathicParkinson's disease and a group of eight age-matched normal control subjects ~eresubjected to an analysis of gait before and after a single session of an OMT protocol. A separate group of 10 patients with Parkinson's disease was given asham-control procedure and tested in the same manner. In the treated group ofpatients with Parkinson's disease, statistically significant increases were observedin stride length, cadence, and the maximum velocities of upper and lower extremitiesafter treatment. There were no significant differences observed in the controlgroups. The data demonstrate that a single session of an OMT protocol hasan immediate impact on Parkinsonian gait. Osteopathic manipulation may be aneffective physical treatment method in the management of movement deficits inpatients with Parkinson's disease.
A solar escalator on Mars: Self‐lifting of dust layers by radiative heating
Authors: Daerden F. , Whiteway J. A. , Neary L. , Komguem L. , Lemmon M. T. , Heavens N. G. , Cantor B. A. , Hébrard E. , Smith M. D. 
Published: August 2015

AbstractDust layers detected in the atmosphere of Mars by the light detection and ranging (LIDAR) instrument on the Phoenix Mars mission are explained using an atmospheric general circulation model. The layers were traced back to observed dust storm activity near the edge of the north polar ice cap where simulated surface winds exceeded the threshold for dust lifting by saltation. Heating of the atmospheric dust by solar radiation caused buoyant instability and mixing across the top of the planetary boundary layer (PBL). Differential advection by wind shear created detached dust layers above the PBL that ascended due to radiative heating and arrived at the Phoenix site at heights corresponding to the LIDAR observations. The self‐lifting of the dust layers is similar to the “solar escalator” mechanism for aerosol layers in the Earth's stratosphere.
Stereoselective Total Synthesis of Myriocin Using Rhodium(II)‐Catalyzed C−H Amination Followed by Alkylation
Authors: Nambu Hisanori , Noda Narumi , Niu Wenqi , Fujiwara Tomoya , Yakura Takayuki 
Published: August 2015

AbstractThe stereoselective total synthesis of myriocin was achieved by using the Du Bois RhII‐catalyzed C−H amination of sulfamate 6, derived from diethyl l‐tartrate, and a subsequent alkylation. The reaction of sulfamate 6 with PhI(OAc)2 and MgO in the presence of Rh2(OAc)4 gave an oxathiazinane N,O‐acetal as the sole product in high yield. Alkylation of the N,O‐acetal with vinylmagnesium bromide in the presence of ZnCl2 proceeded stereoselectively to provide an oxathiazinane bearing a quaternary chiral center in high yield. This route includes the first application of the Du Bois procedure for the construction of a quaternary chiral center.
Charge and Spin Transport in an Organic Molecular Square
Authors: Wu Yilei , Nalluri Siva Krishna Mohan , Young Ryan M. , Krzyaniak Matthew D. , Margulies Eric A. , Stoddart J. Fraser , Wasielewski Michael R. 
Published: August 2015

AbstractUnderstanding electronic communication among multiple chromophoric and redox units requires construction of well‐defined molecular architectures. Herein, we report the modular synthesis of a shape‐persistent chiral organic square composed of four naphthalene‐1,8:4,5‐bis(dicarboximide) (NDI) sides and four trans‐1,2‐cyclohexanediamine corners. Single crystal X‐ray diffraction reveals some distortion of the cyclohexane chair conformation in the solid state. Analysis of the packing of the molecular squares reveals the formation of highly ordered, one‐dimensional tubular superstructures, held together by means of multiple [CH⋅⋅⋅OC] hydrogen‐bonding interactions. Steady‐state and time‐resolved electronic spectroscopies show strong excited‐state interactions in both the singlet and triplet manifolds. Electron paramagnetic resonance (EPR) and electron‐nuclear double resonance (ENDOR) spectroscopies on the monoreduced state reveal electron sharing between all four NDI subunits comprising the molecular square.