bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rheumatic and Musculoskeletal Features of Whipple Disease: A Report of 29 Cases
Authors: Meunier Marine , Puechal Xavier , Hoppé Emmanuel , Soubrier Martin , Dieudé Philippe , Berthelot Jean Marie , Caramaschi Paola , Gottenberg Jacques-Eric , Gossec Laure , Morel Jacques , Maury Emilie , Wipff Julien , Kahan André , Allanore Yannick 
Published: November 2013

Objective.Whipple disease is a rare infection caused by Tropheryma whipplei. Although patients commonly complain of osteoarticular involvement, musculoskeletal manifestations have been poorly described. We report cases of Whipple disease with rheumatic symptoms and describe their clinical presentation, modes of diagnosis, and outcomes.Methods.This retrospective multicenter study included patients with Whipple disease diagnosed and referenced between 1977 and 2011 in 10 rheumatology centers in France and Italy.Results.Twenty-nine patients were included. The median age was 55 years. The median time to diagnosis from first symptoms was 5 years. Polyarthritis was the most frequent presentation (20/29), and was most often chronic, intermittent (19/29), seronegative (22/23), and nonerosive (22/29). In all cases, the symptoms had led to incorrect diagnosis of inflammatory rheumatic disease and immunosuppressants, including biotherapy, were prescribed in most cases (24/29) without success. The diagnosis of Whipple disease was made by histological analysis, molecular biology tests, or both in 21%, 36%, and 43% of the cases, respectively. Duodenal biopsies were performed in most cases (86%). Synovial biopsies were performed in 18% of cases, but all contributed to diagnosis. The clinical outcomes after antibiotic therapy were good for all patients.Conclusion.Polyarthritis is the main feature observed in cases of Whipple disease; it is seronegative and associated with general and gastrointestinal symptoms. The molecular analysis of duodenal tissue and/or other tissues remains the method of choice to confirm the diagnosis. Reducing the time to diagnosis is important because severe late systemic and fatal forms of the disease may occur.
Clinical Features and Associated Factors of Abdominal Pain in Systemic Lupus Erythematosus
Authors: Yuan Shiwen , Lian Fan , Chen Dongying , Li Hao , Qiu Qian , Zhan Zhongping , Ye Yujin , Xu Hanshi , Liang Liuqin , Yang Xiuyan 
Published: November 2013

Objective.To evaluate the clinical characteristics of systemic lupus erythematosus (SLE)-induced abdominal pain in a cohort in South China and identify the risk factors for SLE-induced abdominal pain.Methods.This is a retrospective cohort study of SLE patients with complaint of abdominal pain admitted to the first affiliated university hospital of Sun Yat-sen University between 2002 and 2011. Demographic information, clinical features, laboratory findings, SLE Disease Activity Index, and imaging characteristics were documented.Results.Of the 3823 SLE patients reviewed, 213 patients complained of abdominal pain and 132 cases were considered SLE-induced. The most common causes were lupus mesenteric vasculitis (LMV; 73.5%, 97/132) and lupus pancreatitis (LP; 17.4%, 23/132). Other causes included appendicitis, acute gastroenteritis, and peritonitis. Univariate and multivariate logistic regression analysis indicated the European Consensus Lupus Activity Measurement (ECLAM) score was significantly associated with lupus-induced abdominal pain (OR = 1.858, 95% CI: 1.441–2.394, p < 0.001), LMV (OR = 1.713, 95% CI: 1.308-2.244, p < 0.001), and LP (OR = 2.153, 95% CI: 1.282, 3.617, p = 0.004). The serum D-dimer level (OR = 1.004, 95% CI: 1.002-1.005, p < 0.001) was a strongly associated factor for lupus-induced abdominal pain. Moderate and large amounts of ascetic fluid was significantly associated with lupus-induced abdominal pain and LMV. Elevated liver enzymes was a risk factor for LP (OR = 34.605, 95% CI: 3.591-333.472, p = 0.002).Conclusion.LMV and LP were the leading causes of SLE-induced abdominal pain. The serum D-dimer was a strongly associated factor for lupus-induced abdominal pain. ECLAM score was a reliable index in assessment of SLE-associated abdominal pain. Elevated liver enzymes, and moderate or large amounts of ascites, were positively associated with lupus-induced abdominal pain.
Phylogenetics and molecular identification of theOchlerotatus communiscomplex (Diptera: Culicidae) using DNA barcoding and polymerase chain reaction-restriction fragment length polymorphism
Authors: Namin Hooman H. , Iranpour Mahmood , Sharanowski Barbara J. 
Published: November 2013

AbstractTheOchlerotatus communis(De Geer, 1776) complex consists of four cryptic mosquito species in North America, including:O. communis,Ochlerotatus churchillensis(Ellis and Brust, 1973),Ochlerotatus nevadensis(Chapman and Barr, 1964), andOchlerotatus tahoensis(Dyar, 1916). Most of the morphological characters used for the identification of these species are quantitative and overlap across species. Here we evaluated the efficacy of DNA barcoding for identification of three members of thecommuniscomplex (O. nevadensisis not included in this study) and developed diagnostic restriction fragment length polymorphism (RFLP) patterns forO. communisandO. churchillensis. A phylogeny of 23OchlerotatusLynch Arribálzaga, 1891 species was inferred using mitochondrial cytochromecoxidase subunit I gene sequences. All species included in our analysis within theO. communiscomplex were delineated using cytochromecoxidase subunit I barcodes. However, this complex was recovered as paraphyletic with respect toOchlerotatus abserratus(Felt and Young, 1904) andOchlerotatus implicatus(Vockeroth, 1954), indicating the need for increased genetic and taxonomic sampling to infer the phylogenetic relationships of these taxa. The RFLP profile for multiple field specimens ofO. communiswas distinct from all RFLP patterns forO. churchillensis, and this method can be used as an efficient molecular method for the identification these species.
Brain Human Monoclonal Autoantibody from Sydenham Chorea Targets Dopaminergic Neurons in Transgenic Mice and Signals Dopamine D2 Receptor: Implications in Human Disease
Authors: Cox Carol J. , Sharma Meenakshi , Leckman James F. , Zuccolo Jonathan , Zuccolo Amir , Kovoor Abraham , Swedo Susan E. , Cunningham Madeleine W. 
Published: November 2013

Abstract
How autoantibodies target the brain and lead to disease in disorders such as Sydenham chorea (SC) is not known. SC is characterized by autoantibodies against the brain and is the main neurologic manifestation of streptococcal-induced rheumatic fever. Previously, our novel SC-derived mAb 24.3.1 was found to recognize streptococcal and brain Ags. To investigate in vivo targets of human mAb 24.3.1, VH/VL genes were expressed in B cells of transgenic (Tg) mice as functional chimeric human VH 24.3.1–mouse C-region IgG1a autoantibody. Chimeric human–mouse IgG1a autoantibody colocalized with tyrosine hydroxylase in the basal ganglia within dopaminergic neurons in vivo in VH 24.3.1 Tg mice. Both human mAb 24.3.1 and IgG1a in Tg sera were found to react with human dopamine D2 receptor (D2R). Reactivity of chorea-derived mAb 24.3.1 or SC IgG with D2R was confirmed by dose-dependent inhibitory signaling of D2R as a potential consequence of targeting dopaminergic neurons, reaction with surface-exposed FLAG epitope-tagged D2R, and blocking of Ab reactivity by an extracellular D2R peptide. IgG from SC and a related subset of streptococcal-associated behavioral disorders called “pediatric autoimmune neuropsychiatric disorder associated with streptococci” (PANDAS) with small choreiform movements reacted in ELISA with D2R. Reaction with FLAG-tagged D2R distinguished SC from PANDAS, whereas sera from both SC and PANDAS induced inhibitory signaling of D2R on transfected cells comparably to dopamine. In this study, we define a mechanism by which the brain may be altered by Ab in movement and behavioral disorders.
Impacto Vital del Paso por un COD en la Adolescencia. la Experiencia de Cuatro Adultos de Temuco
Authors: Pérez-Luco Ricardo , Lagos Leonardo , Rozas Rodrigo , Santibáñez Jorge 
Published: November 2013

El estudio, de carácter cualitativo, recoge una mirada retrospectiva de las vivencias asociadas a la experiencia de vida de cuatro hombres que en su adolescencia permanecieron internados en el COD de Temuco por problemas de conducta. Para conseguir el objetivo se hizo uso de la técnica de Entrevista en Profundidad, la cual permitió indagar acerca de lo que los participantes consideran más relevante en sus experiencias, usando como tema eje el periodo de la adolescencia. El análisis de los datos se realiza mediante la técnica Análisis de Contenido Jerárquico Ponderado; y su validación, a través de las técnicas de Triangulación y Contrachequeo. Los resultados emergentes del relato de los participantes muestran que el paso por el COD es un hecho determinante en sus vidas, pues dividen su experiencia en un “antes”, un “durante” y un “después” de éste; siendo muy relevante en los tres momentos los vínculos establecidas, primero con la familia, segundo con los amigos y “tíos” y tercero con familia, pareja y amigos; son éstas las relaciones que los participantes refieren como detonantes y sostenedoras de su comportamiento adaptativo o desadaptativo posterior. La profundidad de la comprensión lograda permite sostener la hipótesis de que una vinculación afectiva tempranamente dañada o interferida,en la adolescencia se puede consolidar como alteración de la vinculaciónenmarcada en una “identidad delictual”, si el joven no logra su “reparación” mediante el apoyo de figuras sustitutas socialmente adaptadas
Percepción de Funcionalidad Familiar y Trauma Infantojuvenil: un estudio cualitativo
Authors: Florenzano Ramón , González Isabel , Errázuriz Paula , Ventura Raúl , Gibbons Allister , Blümel Bernardita , Muñiz Carolina , Marty Carolina , Weil Kristina , Carvajal Cesar 
Published: November 2013

Se comparan las características de quince mujeres hospitalizadas en un hospital general publico en Santiago de Chile, que recuerdan más de tres experienciastraumáticas antes de los 16 años, con 15 casos que no recuerdan ninguno. En los 30 casos se estudian características socio-demográficas, y se aplican las siguientes escalas: Acontecimientos Traumáticos de Perry (TAI), las escalas de percepción familiar de Valdés y Cols (CTF-CSF) y la Escala Abreviada de Conductas de Riesgo (ECRA). Se comparan ambos grupos, constatándose una mayor frecuencia de dificultades en las relaciones interpersonales, disfuncionalidad familiar y conductas de riesgo en las mujeres con antecedentes anamnésticos de polipsicotrauma antes de los 16 años. Se concluye insistiendo en la importancia de la prevención de la violencia intrafamiliar y de los tratamientos adecuados para las víctimas.
Las Dos Culturas de/en la Psicología
Authors: Cornejo A. Carlos 
Published: November 2013

El recurrente diagnóstico que la psicología es una ciencia en crisis puede ser analizado como la pugna entre dos concepciones de psicología: la cientificista y la comprensiva. Ambas coexisten desde los inicios de la disciplina, definiendo objetos y métodos de estudio divergentes y constituyendo hoy culturas antagónicas. El análisis historiográfico muestra que ambas culturas corresponden a una expresiónintradisciplinaria de la dicotomía de las culturas científica y humanista en la sociedad occidental. El análisis muestra también que el reconocimiento de las múltiples dimensiones implicadas en el fenómeno de estudio psicológico apela a la integración de la precisión metodológica de la cultura cientificista y de la adecuación objetal de la cultura comprensiva
Hand and fibrillin‐1 deposition abnormalities in Loeys–Dietz syndrome—expanding the clinical spectrum
Authors: Chung Brian H.Y. , Bradley Tim , Grosse‐Wortmann Lars , Blaser Susan , Dirks Peter , Hinek Aleksander , Chitayat David 
Published: November 2013

ABSTRACTLoeys–Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder characterized by hypertelorism, bifid uvula, cleft palate and arterial tortuosity. We report on a patient with LDS, bearing mutation in the TGFβR2 gene, whose prenatal examination demonstrated clenched fists and club feet, suggesting arthrogryposis multiplex congenita. Postnatal assessment showed digital abnormalities, including brachydactyly, camptodactyly, partial syndactyly and absent distal phalanges. With the lack of fibrillin‐1 microfibril deposition as well as impaired and inadequate elastic fiber assembly in our patient's fibroblasts, we speculate that the skeletal abnormalities seen in this patient with LDS are the result of lack of these components in embryonal perichondrium and in blood vessels. We suggest that LDS should be included in the differential diagnosis of joint contractures seen pre and postnatally. Prenatal diagnosis of LDS would be important in parental counseling and early post natal diagnosis could prompt treatment before the development of detrimental vascular complications. © 2013 Wiley Periodicals, Inc.
Large π‐Conjugated Chromophores Derived from Tetrathiafulvalene
Authors: Jia Hongpeng , Ding Jie , Hauser Andreas , Decurtins Silvio , Liu Shi‐Xia 
Published: November 2013

AbstractA large π‐conjugated chromophore composed of two dipyrido[3,2‐a:2′,3′‐c]phenazine units directly fused to the central tetrathiafulvalene core has been prepared as a bridging ligand and its strong binding ability to Ru2+ to form a new dinuclear complex is presented. The electronic absorption and luminescence spectra and the electrochemical behavior of the free ligand and the Ru2+ complex have been investigated in detail. The free ligand shows a very strong band in the UV region consistent with ligand‐centered π–π* transitions and an intense broad band in the visible region that corresponds to an intramolecular charge‐transfer (ILCT) transition. Upon coordination, a metal‐to‐ligand charge‐transfer band appears at 22520 cm−1, and the ILCT band is bathochromically shifted by 1620 cm−1. These electrochemically amphoteric chromophores have also been characterized by spectro‐electrochemical methods. The oxidized radical species of the free ligand show a strong tendency to undergo aggregation, in which long‐distance attractive interactions overcome the electrostatic repulsion. Moreover, these two new chromophores reveal an ILCT fluorescence with large solvent‐dependent Stokes shifts and quantum efficiencies of 0.052 for the free ligand and 0.016 for its dinuclear Ru2+ complex in CH2Cl2.
Asymmetric Boron Conjugate Additions to Enones in Water Catalyzed by Copper(0)
Authors: Kitanosono Taku , Kobayashi Shū 
Published: November 2013

AbstractThe use of copper(0) powder in water enables chiral induction as well as high catalytic activity. Water plays a prominent role to determine both the catalytic activity and enantioselection. Elevated temperature is indispensable for the regular reaction pathway, and an active species tends to aggregate after the completion of the reaction. Selective deuteration implies enantiofacial differentiation of the deuteron toward an O‐enolate intermediate. Strict substrate specificity suggests the vital interaction between copper(0) and an enone. A very weak isotope effect is indicative of instantaneous protonation. Accordingly, a redox copper cycle (0→II) is tentatively proposed, in which transmetalation of a cyclometalated enone with diboron would furnish a boron enolate, followed by hydrolysis and reductive elimination. However, a single electron transfer process cannot be excluded on the available evidence and a more detailed mechanistic study is under way.
New Insights into Additive Structure Effect on Crystal Agglomeration of L‐Valine
Authors: Yoshiura H. , Nagano H. , Hirasawa I. 
Published: November 2013

AbstractSpecific small amounts of amino acids caused agglomeration of L‐valine (L‐Val) crystals during evaporative crystallization from aqueous solutions. The agglomeration of L‐Val occurred only under acidic condition when guest amino acids satisfied several conditions. Only L‐form amino acids that have carboxylic acid groups and sufficiently long alkyl chain in the side‐chains could induce agglomeration of L‐Val. The length of alkyl chain in the side‐chains controls the degree of agglomeration. Data indicated only 0.5 wt % of L‐2‐aminoadipic acid, which has a similar chemical structure to L‐glutamic acid (L‐Glu), produced the large agglomerates > 1000 μm. The particle size was ∼ 500 μm when using the same amount of L‐Glu. Based on the results from previous tests and this paper, the whole mechanism for the L‐Val agglomeration in the presence of specific guest amino acids has been revealed.
Remarkable Regioisomer Control in the Hydrogel Formation from a Two‐Component Mixture of Pyridine‐End Oligo(p‐phenylenevinylene)s and N‐Decanoyl‐L‐alanine
Authors: Bhattacharjee Subham , Datta Sougata , Bhattacharya Santanu 
Published: November 2013

AbstractN‐Decanoyl‐L‐alanine (DA) was mixed with either colorless 4,4′‐bipyridine (BP) or various derivatives such as chromogenic oligo(p‐phenylenevinylene) (OPV) functionalized with isomeric pyridine termini in specific molar ratios. This mixtures form salt‐type gels in a water/ethanol (2:1, v/v) mixture. The gelation properties of these two‐component mixtures could be modulated by variation of the position of the ′′N′′ atom of the end pyridyl groups in OPVs. The presence of acid–base interactions in the self‐assembly of these two‐component systems leading to gelation was probed in detail by using stoichiometry‐dependent UV/Vis and FTIR spectroscopy. Furthermore, temperature‐dependent UV/Vis and fluorescence spectroscopy clearly demonstrated a J‐type aggregation mode of these gelator molecules during the sol‐to‐gel transition process. Morphological features and the arrangement of the molecules in the gels were examined by using scanning electron microscopy (SEM), atomic force microscopy (AFM), and X‐ray diffraction (XRD) techniques. Calculation of the length of each molecular system by energy minimization in its extended conformation and comparison with the XRD patterns revealed that this class of gelator molecules adopts lamellar organizations. Rheological properties of these two‐component systems provided clear evidence that the flow behavior could be modulated by varying the acid/amine ratio. Polarized optical microscopy (POM), differential scanning calorimetry (DSC), and XRD results revealed that the solid‐phase behavior of such two‐component mixtures (acid/base=2:1) varied significantly upon changing the proton‐acceptor part from BP to OPV. Interestingly, the XRD pattern of these acid/base mixtures after annealing at their associated isotropic temperature was significantly different from that of their xerogels.
Diazadioxa[8]circulenes: Planar Antiaromatic Cyclooctatetraenes
Authors: Hensel Thomas , Trpcevski Denis , Lind Christopher , Grosjean Rémi , Hammershøj Peter , Nielsen Christian B. , Brock‐Nannestad Theis , Nielsen Bjarne E. , Schau‐Magnussen Magnus , Minaev Boris , Baryshnikov Gleb V. , Pittelkow Michael 
Published: November 2013

AbstractIn this paper we describe a new class of antiaromatic planar cyclooctatetraenes: the diazadioxa[8]circulenes. The synthesis was achieved by means of a new acid‐mediated oxidative dimerization of 3,6‐dihydroxycarbazoles to yield the diazadioxa[8]circulenes in high yields. The synthetic protocol appears to be general, and is a one‐pot transformation in which two CC bonds and two CO bonds are formed with the loss of two molecules of water. We also present a detailed characterization of the optical and electrochemical properties of this new class of stable planar cyclooctatetraenes. The properties of the diazadioxa[8]circulenes are compared with the properties of isoelectronic tetraoxa[8]circulenes and azatrioxa[8]circulenes. We discuss the antiaromatic nature of the planar central cyclooctatetraene moiety. The antiaromatic nature of the planar cyclooctatetraenes was studied by using computational methods (NICS calculations), and these calculations reveal that the central eight‐membered ring has antiaromatic character.
Synthesis of Multifunctionalized 1,2,3,4‐Tetrahydropyridines, 2,3‐Dihydropyridin‐4(1H)‐ones, and Pyridines from Tandem Reactions Initiated by [5+1] Cycloaddition of N‐Formylmethyl‐Substituted Enamides to Isocyanides: Mechanistic Insight and Synthetic Application
Authors: Lei Chuan‐Hu , Wang De‐Xian , Zhao Liang , Zhu Jieping , Wang Mei‐Xiang 
Published: November 2013

AbstractTandem reactions for the efficient synthesis of multifunctionalized 1,2,3,4‐tetrahydropyridines, 2,3‐dihydropyridin‐4(1H)‐ones, and pyridine derivatives have been developed and reaction mechanisms have been investigated. Synthetic cascades are initiated by the Zn(OTf)2‐mediated [5+1] cycloaddition of N‐formylmethyl‐substituted tertiary enamides to isocyanides, thus leading to the versatile heterocyclic enamino imine intermediates. Interception of the intermediates by diastereoselective reduction of imine functionality with Me4NBH(OAc)3 afforded 1,6‐disubstituted trans‐3‐hydroxy‐4‐arylamino‐ or ‐alkylamino‐1,2,3,4‐tetrahydropyridines, whereas acylation of the imino group followed by acidic hydrolysis produced 1,6‐disubstituted 3‐acyloxy‐2,3‐dihydropyridin‐4(1H)‐ones. Aerobic oxidation led to the aromatization followed by intermolecular acyl‐group transfer from the pyridinium nitrogen to the 3‐hydroxy moiety, thereby yielding substituted 3‐acyloxy‐4‐aminopyridines. Synthetic potentials of the resulting products have been demonstrated by expedient and highly stereoselective synthesis of cis,cis‐4,5‐dihydroxy‐2‐phenylpiperidine and trans,trans‐4‐amino‐5‐hydroxy‐2‐phenylpiperidine compounds, which are important in medicinal chemistry, through simple and practical reduction reactions.
Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study: Objectives, Methods, and Cohort Description
Authors: Kanaya Alka M. , Kandula Namratha , Herrington David , Budoff Matthew J. , Hulley Stephen , Vittinghoff Eric , Liu Kiang 
Published: November 2013

BackgroundSouth Asians (individuals from India, Pakistan, Bangladesh, Nepal, and Sri Lanka) have high rates of cardiovascular disease (CVD) that cannot be explained by traditional risk factors. There are few prospective cohort studies investigating antecedents of CVD in South Asians.ObjectivesThe Mediators of Atherosclerosis in South Asians Living in America (MASALA) study is investigating the prevalence, correlates, and outcomes associated with subclinical CVD in a population‐based sample of South Asian men and women age 40–79 years at 2 US clinical field centers.Population and MethodologyThis cohort is similar in methods and measures to the Multi‐Ethnic Study of Atherosclerosis (MESA) to allow for efficient cross‐ethnic comparisons. Measurements obtained at the baseline examination include sociodemographic information, lifestyle and psychosocial factors, standard CVD risk factors, oral glucose tolerance testing, electrocardiography, assessment of microalbuminuria, ankle and brachial blood pressures, carotid intima‐media wall thickness using ultrasonography, coronary artery calcium measurement, and abdominal visceral fat measurement using computed tomography. Blood samples will be assayed for biochemical risk factors. Between October 2010 and March 2013, we enrolled 906 South Asians with mean age of 55 ± 9 years (46% women; 98% immigrants who have lived 27 ± 11 years in the United States). The sociodemographic characteristics of this cohort are representative of US South Asians. Participants are being followed with annual telephone calls for identification of CVD events including acute myocardial infarction and other coronary heart disease, stroke, peripheral vascular disease, congestive heart failure, therapeutic interventions for CVD, and mortality.ConclusionsThe MASALA study will provide novel data on the prevalence and associations of cardiovascular risk factors and subclinical atherosclerosis in South Asians living in the United States.