bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma cell‐rich rejection accompanied by acute antibody‐mediated rejection in a patient with ABO‐incompatible kidney transplantation
Authors: Furuya Maiko , Yamamoto Izumi , Kobayashi Akimitsu , Nakada Yasuyuki , Sugano Naoki , Tanno Yudo , Ohkido Ichiro , Tsuboi Nobuo , Yamamoto Hiroyasu , Yokoyama Keitaro , Yokoo Takashi 
Published: May 2014

AbstractWe report a case of plasma cell‐rich rejection accompanied by acute antibody‐mediated rejection in a patient with ABO‐incompatible kidney transplantation. A 33‐year‐old man was admitted for an episode biopsy; he had a serum creatinine (S‐Cr) level of 5.7 mg/dL 1 year following primary kidney transplantation. Histological features included two distinct entities: (1) a focal, aggressive tubulointerstitial inflammatory cell (predominantly plasma cells) infiltration with moderate tubulitis; and (2) inflammatory cell infiltration (including neutrophils) in peritubular capillaries. Substantial laboratory examination showed that the patient had donor‐specific antibodies for DQ4 and DQ6. Considering both the histological and laboratory findings, we diagnosed him with plasma cell‐rich rejection accompanied by acute antibody‐mediated rejection. We started 3 days of consecutive steroid pulse therapy three times every 2 weeks for the former and plasma exchange with intravenous immunoglobulin (IVIG) for the latter histological feature. One month after treatment, a second allograft biopsy showed excellent responses to treatment for plasma cell‐rich rejection, but moderate, acute antibody‐mediated rejection remained. Therefore, we added plasma exchange with IVIG again. After treatment, allograft function was stable, with an S‐Cr level of 2.8 mg/dL. This case report demonstrates the difficulty of the diagnosis of, and treatment for, plasma cell‐rich rejection accompanied by acute antibody‐mediated rejection in a patient with ABO‐incompatible kidney transplantation. We also include a review of the related literature.
The Association of Maternal Adult Weight Trajectory with Preeclampsia and Gestational Diabetes Mellitus
Authors: Thompson Mary Lou , Ananth Cande V. , Jaddoe Vincent W. V. , Miller Raymond S. , Williams Michelle A. 
Published: May 2014

AbstractBackgroundPreeclampsia (PE) and gestational diabetes mellitus (GDM) adversely affect pregnancy outcomes and the subsequent health of both mother and infant. It is known that elevated pre‐pregnancy body mass index (BMI) is associated with increased risk of these obstetrical complications. However, little is known about the role of adult weight patterns prior to pregnancy.MethodsSelf‐reported weight at ages prior to the current pregnancy was recorded in a prospective cohort study of 3567 pregnant women, allowing assessment of longitudinal pre‐pregnancy weight trajectories and their association with subsequent PE and GDM in the study pregnancy.ResultsWomen who would subsequently experience PE or GDM in the study pregnancy experienced on average almost double the rate of adult weight gain than other women [PE: additional 0.30 kg/year, 95% confidence interval (CI) 0.09, 0.51 and GDM: additional 0.34 kg/year, 95% CI 0.21, 0.48]. Women with mean adult annual weight gain above the 90th percentile (1.4 kg/year) had elevated risk of subsequent PE and GDM independent of their BMI at age 18 and of their obesity status at the time of the study pregnancy. Finite mixture trajectory modelling identified four monotonely ordered, increasing mean weight trajectories. Relative to the second lowest (most common) weight trajectory, women in the highest trajectory were at greater risk of PE [odds ratio (OR) 5.0, 95% CI 2.9, 8.8] and GDM (OR 2.8, 95% CI 1.7, 4.5).ConclusionsThese results indicate that higher adult weight gain trajectories prior to pregnancy may play a role in predisposing women to PE or GDM.
The temporal course of the influence of anxiety on fairness considerations
Authors: Luo Yi , Wu Tingting , Broster Lucas S. , Feng Chunliang , Zhang Dandan , Gu Ruolei , Luo Yue‐Jia 
Published: May 2014

AbstractThis study investigated the potential causes of anxious people's social avoidance. The classic ultimatum game was utilized in concert with electroencephalogram recording. Participants were divided into two groups according to levels of trait anxiety as identified by a self‐report scale. The behavioral results indicate that high‐anxious participants were more prone to reject human‐proposed than computer‐proposed unequal offers compared to their low‐anxious counterparts. The event‐related potential results indicate that the high‐anxious group showed a larger feedback‐related negativity when receiving unequal monetary offers than equal ones, and a larger P3 when receiving human‐proposed offers than computer‐proposed ones, but these effects were absent in the low‐anxious group. We suggest anxious people's social avoidance results from hypersensitivity to unequal distributions during interpersonal interactions.
Determining the Progression of Damage in Materials Subjected to Sustained Random Loads Using an Adaptive Finite Impulse Response Approach
Authors: Lamb M. J. , Rouillard V. 
Published: May 2014

ABSTRACTIt is often important to establish the ability of materials to withstand dynamic loads. This ability is best determined by subjecting the elements to sustained random loads under controlled conditions. It is during these fatigue endurance tests that the loss of structural integrity of a material or an element needs to be quantified. The research presented herein uses a recently developed continuous structural integrity assessment technique to evaluate variations in the mechanical properties (namely stiffness) of materials. The effectiveness of the technique was evaluated by undertaking controlled experiments, during which damage was simulated by varying the stiffness (in this case the length of a cantilever beam) of a physical single degree‐of‐freedom vibratory system subjected to random base excitation. Additional experiments where materials were allowed to naturally decay (structurally) under sustained random loads were also performed. Overall, the results presented in this study indicate that the technique can be a practical and effective tool for detecting small variations in the structural integrity of materials subjected to sustained random loads.
A strike‐slip core complex from the Najd fault system, Arabian shield
Authors: Meyer Sven Erik , Passchier Cees , Abu‐Alam Tamer , Stüwe Kurt 
Published: May 2014

AbstractMetamorphic core complexes are usually thought to be associated with regional crustal extension and crustal thinning, where deep crustal material is exhumed along gently dipping normal shear zones oblique to the regional extension direction. We present a new mechanism whereby metamorphic core complexes can be exhumed along crustal‐scale strike‐slip fault systems that accommodated crustal shortening. The Qazaz metamorphic dome in Saudi Arabia was exhumed along a gently dipping jog in a crustal‐scale vertical strike‐slip fault zone that caused more than 25 km of exhumation of lower crustal rocks by 30 km of lateral motion. Subsequently, the complex was transected by a branch of the strike‐slip fault zone, and the segments were separated by another 30 km of lateral motion. Strike‐slip core complexes like the Qazaz Dome may be common and may have an important local effect on crustal strength.
The Arabidopsis LecRK‐VI.2 associates with the pattern‐recognition receptor FLS2 and primes Nicotiana benthamiana pattern‐triggered immunity
Authors: Huang Pin‐Yao , Yeh Yu‐Hung , Liu An‐Chi , Cheng Chiu‐Ping , Zimmerli Laurent 
Published: May 2014

SummaryPattern‐triggered immunity (PTI) is broad spectrum and manipulation of PTI is believed to represent an attractive way to engineer plants with broad‐spectrum disease resistance. PTI is activated upon perception of microbe‐associated molecular patterns (MAMPs) by pattern‐recognition receptors (PRRs). We have recently demonstrated that the L‐type lectin receptor kinase‐VI.2 (LecRK‐VI.2) positively regulates Arabidopsis thaliana PTI. Here we show through in vitro pull‐down, bimolecular fluorescence complementation and co‐immunoprecipitation analyses that LecRK‐VI.2 associates with the PRR FLS2. We also demonstrated that LecRK‐VI.2 from the cruciferous plant Arabidopsis remains functional after interfamily transfer to the Solanaceous plant Nicotiana benthamiana. Wild tobacco plants ectopically expressing LecRK‐VI.2 were indeed more resistant to virulent hemi‐biotrophic and necrotrophic bacteria, but not to the fungal pathogen Botrytis cinerea suggesting that, as with Arabidopsis, the LecRK‐VI.2 protective effect in N. benthamiana is bacteria specific. Ectopic expression of LecRK‐VI.2 in N. benthamiana primed PTI‐mediated reactive oxygen species production, mitogen‐activated protein kinase (MAPK) activity, callose deposition and gene expression upon treatment with the MAMP flagellin. Our findings identified LecRK‐VI.2 as a member of the FLS2 receptor complex and suggest that heterologous expression of components of PRR complexes can be used as tools to engineer plant disease resistance to bacteria.
Comprehensive metabolomic study of platelets reveals the expression of discrete metabolic phenotypes during storage
Authors: Paglia Giuseppe , Sigurjónsson Ólafur E. , Rolfsson Óttar , Valgeirsdottir Soley , Hansen Morten Bagge , Brynjólfsson Sigurður , Gudmundsson Sveinn , Palsson Bernhard O. 
Published: May 2014

BackgroundPlatelet (PLT) concentrates are routinely stored for 5 to 7 days. During storage they exhibit what has been termed PLT storage lesion (PSL), which is evident by a loss of hemostatic function when transfused into patients. The overall goal of this study was to obtain a comprehensive data set describing PLT metabolism during storage.Study Design and MethodsThe experimental approach adopted to achieve this goal combined a series of standard assays to monitor the quality of stored PLTs and a deep‐coverage metabolomics study using liquid chromatography coupled with mass spectrometry performed on both the extracellular and the intracellular environments. During storage we measured 174 different variables in 6 PLT units, collected by apheresis. Samples were collected at eight different time points resulting in a data set containing more than 8000 measurements.ResultsStored PLTs did not undergo a monotonic decay, but experienced systematic changes in metabolism reflected in three discrete metabolic phenotypes: The first (Days 0‐3) was associated with active glycolysis, pentose phosphate pathway, and glutathione metabolism and down regulation of tricarboxylic acid (TCA) cycle. The second (Days 4‐6) was associated with a more active TCA cycle as well as increased purine metabolism. A third metabolic phenotype of less clinical relevance (Days 7‐10) was associated with a faster decay of cellular metabolism.ConclusionPSL is not associated with a linear decay of metabolism, but rather with successive metabolic shifts. These findings may give new insight into the mechanisms underlying PSL and encourage the deployment of systems biology methods to PSL.
Contrast and transferability of parameters of lumped water balance models in the Segura River Basin (Spain)
Authors: Pellicer‐Martinez Francisco , Martínez‐Paz José M. 
Published: May 2014

AbstractKnowing the water resources in a river basin is a key aspect to appropriate water planning, and they can be estimated by lumped water balance models. The possibility to transfer the calibrated parameters of a contrasted model to non‐gauged ones improves this knowledge with no need for direct measurements. This work studies the transferability of the parameters of the lumped models in five catchments in the southeast of Spain, testing the influence of the snow and the effect of serial autocorrelation in the goodness of fit. The results are also compared with those of the distributed model of reference in Spain (SIMPA). As principal results, the abcd model is the selected one, the snow effect is negligible, the transferability of parameters for this case is not totally possible, and serial autocorrelation must be included for this kind of modelling.
Causes and consequences of epigenetic regulation in wound healing
Authors: Ti Dongdong , Li Meirong , Fu Xiaobing , Han Weidong 
Published: May 2014

AbstractWound healing is a complex and systematic tissue level response to mechanical and chemical injuries that may cause the release of growth factors, cytokines, and chemokines by damaged tissues. For the complex features of these restorative processes, it is a crucial challenge to identify the relevant cell types and biochemical pathways that are involved in wound healing. Epigenetic mechanisms, such as DNA methylation, histone modification, and noncoding regulatory RNA editing, play important roles in many biological processes, including cell proliferation, migration and differentiation, signal pathway activation or inhibition, and cell senescence. Epigenetic regulations can coordinately control a considerable subset of known repair genes and thus serve as master regulators of wound healing. An abundance of evidence has also shown that epigenetic modifications participate in the short‐ and long‐term control of crucial gene expression and cell signal transduction that are involved in the healing process. These data provide a foundation for probable epigenetic‐based therapeutic strategies that are aimed at stimulating tissue regeneration. This review describes the epigenetic alterations in different cellular types at injury sites, induced signals, and resulting tissue repair. With the increased interest in the epigenetics of wound and repair processes, this field will soon begin to flourish.
Identification of a transcriptional signature for the wound healing continuum
Authors: Peake Matthew A. , Caley Mathew , Giles Peter J. , Wall Ivan , Enoch Stuart , Davies Lindsay C. , Kipling David , Thomas David W. , Stephens Phil 
Published: May 2014

AbstractThere is a spectrum/continuum of adult human wound healing outcomes ranging from the enhanced (nearly scarless) healing observed in oral mucosa to scarring within skin and the nonhealing of chronic skin wounds. Central to these outcomes is the role of the fibroblast. Global gene expression profiling utilizing microarrays is starting to give insight into the role of such cells during the healing process, but no studies to date have produced a gene signature for this wound healing continuum. Microarray analysis of adult oral mucosal fibroblast (OMF), normal skin fibroblast (NF), and chronic wound fibroblast (CWF) at 0 and 6 hours post‐serum stimulation was performed. Genes whose expression increases following serum exposure in the order OMF < NF < CWF are candidates for a negative/impaired healing phenotype (the dysfunctional healing group), whereas genes with the converse pattern are potentially associated with a positive/preferential healing phenotype (the enhanced healing group). Sixty‐six genes in the enhanced healing group and 38 genes in the dysfunctional healing group were identified. Overrepresentation analysis revealed pathways directly and indirectly associated with wound healing and aging and additional categories associated with differentiation, development, and morphogenesis. Knowledge of this wound healing continuum gene signature may in turn assist in the therapeutic assessment/treatment of a patient's wounds.
Comparison studies of the in vivo treatment of full‐thickness excisional wounds and burns by an artificial bilayer dermal equivalent and J‐1 acellular dermal matrix
Authors: Guo Rui , Teng Jianying , Xu Shaojun , Ma Lie , Huang Aibin , Gao Changyou 
Published: May 2014

AbstractThe effects upon skin repair were compared between a homemade bilayer dermal equivalent (BDE), composed of a collagen/chitosan porous scaffold and a silicone membrane, and J‐1 acellular dermal matrix (ADM), a commercial ADM that is used widely in China to treat various skin defects. Full‐thickness excisional and burn wounds were prepared on the backs of pigs and then treated with the BDE and J‐1 ADM. Biopsy specimens were harvested on days 7, 14, and 21 after surgery for gross, biochemical, and molecular examinations. In comparison with the burn wounds, the excisional wounds showed accelerated granular tissue formation and superior integration with the equivalents, regardless of their type. Immunohistochemical, immunofluorescence, real time quantitative polymerase chain reaction and Western blotting analyses showed that the vascularization rates in the excisional wounds group were also significantly faster than those of the burn group for both dermal equivalents. There was no significant difference between J‐1 ADM and BDE treatment on the formation of newly formed blood vessels for the excisional wounds at days 7, 14, and 21. However, there was a significant difference in the number of nascent blood vessels formed in the burn wounds after treatment with J‐1 ADM compared with BDE. The highest numbers of newly formed and mature blood vessels were present in the J‐1 ADM‐treated excisional wounds after 21 days. Ultrathin skin grafts were further transplanted on to the regenerated dermis for 28 days, resulting in the repair of the full‐thickness wounds and production of a structure similar to normal skin.
Full‐thickness splinted skin wound healing models in db/db and heterozygous mice: Implications for wound healing impairment
Authors: Park Shin Ae , Teixeira Leandro B. C. , Raghunathan Vijay Krishna , Covert Jill , Dubielzig Richard R. , Isseroff Roslyn Rivkah , Schurr Michael , Abbott Nicholas L. , McAnulty Jonathan , Murphy Christopher J. 
Published: May 2014

AbstractsThe excisional dorsal full‐thickness skin wound model with or without splinting is widely utilized in wound healing studies using diabetic or normal mice. However, the effects of splinting on dermal wound healing have not been fully characterized, and there are limited data on the direct comparison of wound parameters in the splinted model between diabetic and normal mice. We compared full‐thickness excisional dermal wound healing in db/db and heterozygous mice by investigating the effects of splinting, semi‐occlusive dressing, and poly(ethylene glycol) treatment. Two 8‐mm full‐thickness wounds were made with or without splinting in db/db and heterozygous mice. Body weights, splint maintenance, wound contraction, wound closure, and histopathological parameters including reepithelialization, wound bed collagen deposition, and inflammation were compared between groups. Our results show that silicone splint application effectively reduced wound contraction in heterozygous and db/db mice. Splinted wounds, as opposed to nonsplinted wounds, exhibited no significant differences in wound closure between heterozygous and db/db mice. Finally, polyethylene glycol and the noncontact dressing had no significant effect on wound healing in heterozygous or db/db mice. We believe these findings will help investigators in selection of the appropriate wound model and data interpretation with fully defined parameters.
Wound research funding from alternative sources of federal funds in 2012
Authors: Baquerizo Nole Katherine L. , Yim Elizabeth , Van Driessche Freya , Davidson Jeffrey M. , Martins‐Green Manuela , Sen Chandan K. , Tomic‐Canic Marjana , Kirsner Robert S. 
Published: May 2014

AbstractChronic wounds represent a major healthcare burden, costing $25 billion annually, and are associated with high mortality. We previously reported that cutaneous wound healing represented only 0.1% ($29.8 million) of the National Institutes of Health budget. This current study focuses on quantifying the contribution by federal agencies other than the National Institutes of Health for fiscal year 2012. Federal databases including USA Spending, Veterans Affairs, Tracking Accountability in Government Grants Systems, Health Services Research Projects in Progress, and Patient‐Centered Outcomes Research Institute, were searched for individual projects addressing wound healing. Twenty‐seven projects were identified, totaling funding of $16,588,623 (median: $349,856). Four sponsor institutions accounted for 74% of awarded funds: Department of the Army, National Science Foundation, Department of Veterans Affairs, and Agency for Healthcare Research & Quality. Research projects and cooperative agreements comprised 44% and 37% of awarded grants. New applications and continuing projects represented 52% and 37%. Wound healing represented 0.15% of total medical research funded by the non‐National Institutes of Health federal sector. Compared with potential impact on US public health, federal investment in wound research is exiguous. This analysis will draw attention to a disproportionately low investment in wound research and its perils to American public health.
Recurring pressure ulcers: Identifying the definitions. A National Pressure Ulcer Advisory Panel white paper
Authors: Tew Cindy , Hettrick Heather , Holden‐Mount Sarah , Grigsby Rebekah , Rhodovi Julie , Moore Lyn , Ghaznavi Amir M. , Siddiqui Aamir 
Published: May 2014

AbstractCurrently, there is a lack of consensus regarding the accepted terminology pertaining to the pressure ulcer healing progression and recidivism. This lack of uniformity can negatively impact initiation of treatment pathways, completion of appropriate interventions, clinical documentation, medical coding, patient education, discharge planning and healthcare revenue through out the healthcare system. The purpose of this paper is to introduce a standard nomenclature as it pertains to pressure ulcer healing progression and any recidivism that may occur. The National Pressure Ulcer Advisory Panel has formulated a framework of terms regarding pressure ulcer progression. We also developed a clearer nomenclature for lack of progress and recidivism of pressure ulcers. This document should serve as a starting point for the discussion of the pressure ulcer care, research, and terminology.
Results from Ireland’s 2014 Report Card on Physical Activity in Children and Youth
Authors: Harrington Deirdre M. , Belton Sarahjane , Coppinger Tara , Cullen Muireann , Donnelly Alan , Dowd Kieran , Keating Teresa , Layte Richard , Murphy Marie , Murphy Niamh , Murtagh Elaine , Woods Catherine 
Published: May 2014

Background:Physical activity (PA) levels are a key performance indicator for policy documents in Ireland. The first Ireland Report Card on Physical Activity in Children and Youth aims to set a robust baseline for future surveillance of indicators related to PA in children and youth.Methods:Data collected between 2003−2010 on more than 35,000 7- to 18-year-old children and youth were used and graded using a standardized grading system for 10 indicators.Results:Grades assigned for the indicators were as follows: overall physical activity levels, D-; sedentary behavior (TV viewing), C-; organized sport participation, C-: physical education, D-; active play, inconclusive (INC); active transportation, D; school, C-, community and the built environment, B; family, INC; and government, INC.Conclusions:PA recommendations exist in Ireland but this Report Card has shown that participation is still low. A number of promising policies, programs and services are in place but these require thorough evaluation and adequate resourcing. Agreement and implementation of a common framework for the systematic surveillance of indictors related to PA of children and youth is necessary to monitor change over time and ensure the impact of promising work is captured.