bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cataract and Retinal Detachment in Patients with Severe Atopic Dermatitis Who Were Withdrawn from the Use of Topical Corticosteroid
Authors: Taniguchi Hiroko , Ohki Orina , Yokozeki Hiroo , Katayama Ichiro , Tanaka Akiko , Kiyosawa Motohiro , Nishioka Kiyoshi 
Published: April 2015

AbstractMany patients with severe atopic dermatitis (AD) in Japan are afflicted with persistent erythema of the face (atopic red face) that is not only resistant to topical corticosteroid, but often becomes worse with its use. During a three‐year period (1991–1993), we treated 79 inpatients with severe AD by a combination of careful daily skin care, use of emollients, and exclusion of exacerbating factors. Occular complications before and after treatment were examined in these cases. After withdrawal of topical corticosteroid, almost all of the patients showed a temporary worsening of their skin condition. Immediately thereafter, their occular symptoms did not change. Cataract was found in 20 cases (25.3%), and retinal detachment in 9 (11.4%). After 2 months, 11 cases of cataract and 5 cases of retinal detachment in the peripheral retina were observed. However, these incidences were similar to the numbers reported in Japan during conventional treatment with topical corticosteroid.The development of cataract or retinal detachment had no relationship to serum IgE levels, personal history of respiratory atopy, the duration of topical corticosteroid use on the face, or treatment with systemic corticosteroid. Our obsevations suggest that patients who habitually tap or rub their faces strongly tend to develop cataract or retinal detachment at a statistically significant higher frequency.Patients wih AD should have ophthalmologic examinations every one to two months for at least one year after a facial oozing attack or withdrawal of corticosteroid.
A Case of Perineal Schwannoma Resembling a Skin Tag
Authors: Kim Young Koo , Ahn Sung Ku , Lee Seung Hun 
Published: April 2015

AbstractWe describe a case of perineal schwannoma (neurilemmoma) that resembled a skin tag. The structure was composed of a 1.5 cm × 1.4 cm × 1 cm sized mass and a movable stalk. After excision of the mass from the stalky root with scissors, H & E staining of the specimen revealed an encapsulated intradermal mass composed of Antoni‐A type and Antoni‐B type tissue.
Current Consensus and Update on Psoriasis Therapy: A Perspective from the U.S.
Authors: Koo John Y. M. 
Published: April 2015

AbstractPsoriasis is one of the more common forms of chronic dermatitis in the world. The latest U.S.‐wide epidemiological study conducted by the author revealed a prevalence rate of 2.6% of the population, which translates to over 6 million Americans (1). Psoriasis comes in many different degrees of severity and responsiveness to treatment modalities. Some cases are very mild and quite responsive to treatment, while others are so severe, chronic and recalcitrant that they test the skill and ingenuity of the best clinicians. Fortunately, there are also many different treatment options. Topical therapies include crude coal tar, anthralin, corticosteroids, calcipotriol, and tazarotene. Phototherapy may be a better choice in patients with more extensive psoriasis; UVB or psoralen plus subsequest UVA (PUVA) can be used. There are also a host of systemic therapies (cyclosporine, methotrexate, acitretin), which can be chosen in recalcitrant cases, or when topical or phototherapy is impractical. Importantly, significant increases in efficacy can be obtained by combining multiple therapies (Re‐PUVA, topical calcipotriol plus topical halobetasol) and significant decreases in side effects can be obtained by transitioning through or rotating between therapies (cyclosporine transitioning into acitretin).
Analysis of the T Cells that Are Potentially Involved in Autoantibody Production in Pemphigus Vulgaris
Authors: Hertl Michael , Riechers Regine 
Published: April 2015

AbstractPemphigus vulgaris (PV) is a classical example of an antibody‐mediated autoimmune disease of the skin. Direct evidence exists that autoantibodies against the desmosomal adhesion molecule, desmoglein 3 (Dsg3), are critical in the pathogenesis of this disease. The transfer of serum IgG antibodies reactive with Dsg3 into newborn mice induces a bullous skin disease resembling PV. Autoreactive T cell responses to Dsg3 may be critical in the pathogenesis of PV because 1) antibody production generally requires T cell help, 2) the involvement of CD4+ T lymphocytes in PV has been suggested by the strong association with distinct HLA class II alleles, and 3) T cell recognition of epitopes of Dsg3 may be crucial for the initiation and perpetuation of the production of Dsg3‐specific autoantibodies by B cells. We and others have identified autoreactive T cells recognizing distinct epitopes of the extracellular portion of Dsg3 in PV patients. These autoreactive CD4+ T cells preferentially produced TH2 cytokines such as IL‐4, and IL‐10. Autoantibodies of the TH2‐dependent IgG4 subtype are preferentially seen in active stages of PV disease, while autoantibodies of the TH1‐dependent IgG1 subclass are predominant upon remission of PV. Healthy individuals who carried HLA class II alleles similar or identical to those found to be highly prevalent in PV also developed autoreactive T cell responses to Dsg3. Autoreactive T cells from PV patients produced both TH1 and TH2 cytokines; autoreactive T cells from normals produced TH0 cytokines. These observations suggest that Dsg3‐specific T cells may provide targets to eventually modulate the T cell‐dependent production of pathogenic autoantibodies in PV.
Clinicopathologic Analysis of 124 Cases of Adult T‐Cell Leukemia/Lymphoma with Cutaneous Manifestations: The Smouldering Type with Skin Manifestations Has a Poorer Prognosis than Previously Thought
Authors: Setoyama Mitsuru , Katahira Yoshihiko , Kanzaki Tamotsu 
Published: April 2015

AbstractAdult T‐cell leukemia/lymphoma (ATLL) commonly involves the skin as well as peripheral blood and lymph nodes. During the last 15 years we have studied 124 cases of ATLL with specific skin manifestations. Twenty‐one patients (16.9%) were classified as acute, 21 (16.9%) as chronic, 26 (21.0%) as lymphoma, and 56 (45.2%) as smouldering according to Shimoyama's classification. Many patiens had nodules/tumors (34.7%), erythematous plaques (22.6%), and erythematous papules (19.4%) similar to those occurring with other cutaneous T‐cell lymphomas. Some patients displayed characteristic skin manifestations resembling non‐neoplastic cutaneous disorders.The median survival time (MST) of all patients was 12.0 months. The MSTs of individual clinical types were: acute type, 4 months; chronic type, 14 months; lymphoma type, 7 months; and smouldering type, 16 months. In the smouldering type, cases with a deeper infiltration pattern (MST, 14 months) had a more aggressive course than those with a superficial infiltration pattern (MST, 24 months) (p<0.05). The results indicate that smouldering type ATLL with skin manifestations may have a worse prognosis than without skin manifestations. Moreover, some cases of the smouldering type with specific skin lesions should be classified into another group with a much poorer prognosis.
Characteristics of Streptococcus Species Isolated from Infectious Skin Diseases
Authors: Higaki Shuichi , Kitagawa Taro , Morohashi Masaaki , Yoshida Ikuko , Yamagishi Takayoshi 
Published: April 2015

AbstractDuring the period from January of 1995 to June of 1998, 27 β‐hemolytic streptococci were isolated from 25 cases of infectious skin diseases including secondary infections, impetigo, phlegmone, and paronychia. The rate of β‐hemolytic streptococci among all kinds of the isolates was found to be similar during those 4 years, ranging from 3.5% to 5.6%. Staphylococcus aureus were found to coexist with β‐hemolytic streptococci in 20 (80%) out of 25 cases. β‐hemolytic streptococci were also often associated with coagulase‐negative staphylococci, gram‐positive rods, or other species. Twelve cases (48%) carried β‐hemolytic streptococci predominantly. Most β‐hemolytic streptococci showed high susceptibilities to all antimicrobials tested; however S. agalactiae showed no susceptibility to gentamicin. The evaluation of characteristics of Streptococcus species is very important for selecting the right antimicrobial agents and the proper term of chemotherapy.
Encephalocraniocutaneous Lipomatosis: A New Case Report and Review of the Literature
Authors: Romiti Ricardo , Rengifo Jaime A. , Arnone Marcelo , Sotto Mirian N. , Valente Neusa Y. , Jansen Thomas 
Published: April 2015

AbstractEncephalocraniocutaneous lipomatosis is a rare neurocutaneous syndrome characterized by lipomatous hamartomas ranging in size from a few millimeters to several centimeters and affecting the head. Ocular anomalies and a variable degree of mental retardation with or without convulsions are usually observed. This disorder should be distinguished from other mosaic neurocutaneous phenotypes such as Proteus syndrome, oculocerebrocutaneous syndrome, and nevus sebaceous syndrome. We report the clinicopathologic findings of a 4‐year‐old Brazilian girl affected by this syndrome and review the literature. To our best knowledge, this is the first documented case of encephalocraniocutaneous lipomatosis occuring sporadically in South America.
Primary Cutaneous Mucormycosis in a Trauma Patient
Authors: Song Won Keun , Park Hyang Joon , Cinn Yong Woo , Rheem Insoo , Pai Hyunjoo , Shin Jong Hee 
Published: April 2015

AbstractWe report a rare case of primary cutaneous mucormycosis caused by Rhizopus oryzae that occurred in an immunocompetent trauma patient. The patient had encrusted erythematous plaques with pustules on the left shin, which had been abraded in a traffic accident. Histologic examination revealed widespread granulomatous inflammation and characteristic broad, non‐septate hyphae with right‐angle branching in the dermis. The infection was cured with intravenous amphotericin B therapy.
Port‐Wine‐Stain (Nevus Flammeus), Congenital Becker's Nevus, Café‐au‐lait‐Macule and Lentigines: Phakomatosis Pigmentovascularis Type Ia—A New Combination
Authors: Joshi Arun , Garg Vijay Kumar , Agrawal Sudha , Agarwalla Arun , Thakur Amarnath 
Published: April 2015

AbstractA 16‐year‐old male had brown macules in a geographic pattern with increased terminal hair on the back and dusky red partially blanchable non progressing macules on his left thigh since birth. Clinical diagnoses of Becker's nevus and port‐wine‐stain were made and confirmed histopathologically. In addition, he had multiple lentigines on the face and trunk and a single café‐au‐lait‐macule on his chest.
Mucha‐Habermann Disease‐like Eruptions Due to Tegafur
Authors: Kawamura Keiko , Tsuji Takuo , Kuwabara Yoshiyuki 
Published: April 2015

AbstractThe first case of Mucha‐Habermann disease‐like drug eruptions due to Tegafur is reported. A 59‐year‐old man noticed various skin lesions after he had taken 300 mg of Tegafur daily for about 200 days. The patient had papulonecrotic eruptions on his trunk and extremities. The histology from a papular lesion revealed epidermal necrosis surrounded by spongiosis, perivascular inflammatory infiltrations composed of lymphocytes and erythrocytes, and endothelial swelling. The etiology of Mucha‐Habermann disease is not known, but an immune mechanism may be supported by our case.
Detection of Human Papilloma Virus Type 58 in a Case of a Perianal Bowen's Disease Coexistent with Adult T‐cell Leukemia
Authors: Uezato Hiroshi , Hagiwara Keisuke , Maruno Motoyoshi , Ramuzi Saeef Taher , Khaskhely Noor Mohammad , Oshiro Minoru , Asato Tsuyoshi , Nakashima Yasutsugu , Nonaka Shigeo 
Published: April 2015

AbstractA case of Bowen's disease (BD) that appeared in the perianal region of a 65‐year‐old Japanese woman coexistent with chronic adult T cell leukemia (ATL) is described. Histopathological findings revealed that irregularly arranged tumor cells with atypical nuclei throughout the epidermis, which itself disclosed hyperkeratosis, dyskeratotic cells, and clumping cells. Positive staining for HPV antigens was immunohistochemically seen in several nuclei of the tumor cells. Electron microscopic study of the tumor tissue disclosed virus particles of about 50 nm in diameter form the squamous cells. A positive band at 256 bp was obtained by PCR using HPV‐L1 primer. The amplified DNA by L1 primer completely corresponded to that of HPV‐58.
A Case of Multiple Sebaceous Epithelioma: Analysis of Microsatellite Instability
Authors: Ueda Masato , Wang Yin , Sugimura Haruhiko , Tamura Shingo , Kondoh Masafumi , Ichihashi Masamitsu 
Published: April 2015

AbstractSebaceous gland tumor is a rare disease that is a sign of Muir‐Torre syndrome, an autosomal, dominantly inherited genodermatosis characterized by the presence of at least one sebaceous gland tumor and a minimum of one internal malignancy. Recent studies have indicated that defective DNA mismatch repair occurs in Muir‐Torre syndrome. Cutaneous lesions may occur before diagnosis of the internal cancer. We describe a 64‐year‐old male patient with multiple sebaceous epitheliomas with no evident internal malignancy. Microsatellite instability, determined by examining dinucleotide CA repeats at the microsatellite loci, was observed in DNA from one sebaceous epithelioma but not from the other two sebaceous epitheliomas or from one basal cell epithelioma with sebaceous differentiation, suggesting that this condition is unlikely to be due to germ‐line mutation of mismatch repair genes.
A Poroid Neoplasia Arising Close to a Seborrheic Keratosis and a Trichoepithelioma
Authors: Nagore Eduardo , Díaz Felipe , Sánchez‐Motilla José M. , Prats Amelia , García‐Castell Julia , Aliaga Adolfo 
Published: April 2015

AbstractA 69‐year‐old woman had a well‐defined, slightly raised, brownish, keratotic plaque with an excentric group of roughly circular, bluish, dome nodules on her right scapular area. Histological study revealed the presence of an eccrine poroma demonstrating features of eccrine poroma, hidroacanthoma simplex, and dermal duct tumor and arising in a lesion of seborrheic keratosis and a trichoepithelioma. In the eccrine poroma region, an area with malignant changes was evident. The findings in this case support the view of eccrine poroma as a spectrum of histological variants and the possibility of malignant transformation from a eccrine poroma towards porocarcinoma. The association with seborrheic keratosis is most probably coincidental, and the trichoepithelioma was probably due to induction of the tumoral stroma on adjacent follicular epithelia.
Sweat Gland Adenoma with Predominant Myoepithelial Differentiated Features: Case Report and Immunohistochemical Study
Authors: Xinzhi Fang , Zhineng Yu , Zizen Wang 
Published: April 2015

AbstractA 56‐year‐old man presented with a subcutaneous mass adjacent to the sternoclavicular joint region, which had predominant spindle‐shaped myoepithelial cells and a small number of tubular or trabecular epithelial cells that resembled eccrine differentiation under a light microscope. Immunohistochemical studies showed positive staining for muscle‐specific actin and vimentin in the myoepithelial cells, but staining was negative for S‐100 protein and keratin. The tubular and trabecular epithelial cells stained positively for keratin, EMA and CEA. We believe that this rare tumor had the potential for biphasic differentiation and should be differentiated from other biphasic differentiated or mixed tumors in this site. Immunohistochemical staining was useful for diagnosis and differential diagnosis.
Postoperative Alveolar Hydatid Disease with Cutaneous‐Subcutaneous Involvement
Authors: Ambo Midori , Adachi Kouichi , Ohkawara Akira 
Published: April 2015

AbstractThe first Japanese case of alveolar hydatid disease with cutaneous‐subcutaneous lesions is reported. The patient, a 58‐year‐old man who developed an indurated subcutaneous tumor on the right side of the abdomen, had had partial hepatectomy of the right lobe for echinococcosis thirteen years earlier. Clinically, the tumor was adherent with a fistulosis communication to deeper structures. Histopathologically, multiple PAS‐positive cuticular layers with foreign body granulomas and fibrosis were observed between the dermis and subcutaneous fatty tissue. Surgical excision of the swelling provided the patient with temporary relief. To our knowledge, only eight cases of subcutaneous alveolar hydatid disease have been reported throughout the world. Ours, the ninth case, highlights the importance and difficulty of treating of alveolar hydatid disease.
Unilateral Schamberg Disease in a 14‐Year‐Old Japanese Boy
Authors: Nagata Ken , Danno Kiichiro , Tanaka Souichi 
Published: April 2015

AbstractWe report a 14‐year‐old Japanese boy who has had asymptomatic, multiple, reddish‐brown macules and petechiae distributed segmentally only in the right lower extremity for the last 6 months. Histological examination showed a perivascular lymphohistiocytic infiltrate in the papillary dermis, extravasation of red blood cells, and hemosiderin deposition. Treatment with tranilast and topical corticosteroid was dramatically effective. Although the histological findings were compatible with those of Schamberg disease, this case was unusual because the patient was very young and only one extremity was affected.
Acute Generalized Exanthematous Pustulosis Induced by Salazosulfapyridine in a Patient with Ulcerative Colitis
Authors: Kawaguchi Masakazu , Mitsuhashi Yoshihiko , Kondo Shigeo 
Published: April 2015

AbstractWe report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis. A 26‐year‐old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39°C one day after the administration of salazosulfapyridine. A skin biopsy specimen disclosed intracorneal pustule composed of neutrophils and lymphohistiocytic infiltrate in the dermis. A drug lymphocyte stimulation test for salazoslufapyridine was positive, but the patch test was negative. Immunological mechanisms are suggested in the pathogenesis of psoriasis and ulcerative colitis. We suspect that a similar immunological pathway played a role in the pathogenesis of AGEP appearing in psoriasis and ulcerative colitis.
Follow‐up of Clinical Efficacy of Iontophoresis Therapy for Postherpetic Neuralgia (PHN)
Authors: Ozawa Akira , Haruki Yasuo , Iwashita Kenichi , Sasao Yuki , Miyahara Motomi , Sugai Junichi , Matsuyama Takashi , Iizuka Mariko , Kawakubo Yo , Nakamori Michiyo , Ohkido Muneo 
Published: April 2015

AbstractA great variety of therapies have been attempted for PHN, including pharmacotherapy and physical therapy. However, there has been no decisive treatment, and reports of the clinical efficacy of all available therapies have been rather controversial. Almost all studies conducted so far have looked only at short‐term therapeutic efficacy, and only a few investigators have conducted long‐term observations or studies on long‐term outcome. We followed up the clinical efficacy of iontophoresis therapy using lidocaine and methylprednisolone in 197 PHN patients. Monitoring conducted for an average of 4 years after completion of the treatment showed that pain remained unchanged or improved compared to pain observed upon completion of the treatment in 90.4% of patients. Although 42.6% of patients were still continuing some treatment, 90.9% were found to be able to take care of themselves. Findings obtained were reviewed and discussed from various viewpoints. Our findings showed that iontophoresis therapy is not only effective at the end of the treatment, but its efficacy is maintained over a long period of time, indicating that it is clinically very useful for the treatment of PHN.
Topical Tocoretinate Improved Hypertrophic Scar, Skin Sclerosis in Systemic Sclerosis and Morphea
Authors: Mizutani Hitoshi , Yoshida Toshimichi , Nouchi Nobuhiro , Hamanaka Hiroko , Shimizu Masayuki 
Published: April 2015

AbstractFour patients with systemic scleroderma (SSc), 4 patients with morphea, and 4 patients with hypertrophic scar were treated with topical tocoretinate for 6 months to 3 years and studied clinically and histopathologically. Clinically, all of the lesions responded to this therapy. The stiffness of the skin lesions, glossy appearance of the lesions, and telangiectasia improved. Histopathologically, the proliferated collagen fibers decreased in thickness, and the inter‐fiber spaces increased. Immunoreactive tenascin‐C expressed in the proliferated deep dermal fibers of the SSc and hypertrophic scar lesions was markedly decreased compared with the level before the topical tocoretinate therapy.Topical tocoretinate has been used for the treatment of ulcers; it is also a potent treatment for sclerotic skin diseases.
Differential Expression of Interferon Gamma by Mitogen‐Stimulated Peripheral Blood Mononuclear Cells among Kuwaiti Psoriasis Patients
Authors: Mahmoud Fadia , Abul Habib , Al‐Seleh Qassem , Morgan Gareth , Haines Donald , Al‐Ramly Mahmoud , Burleson Joe , Kreutzer Donald 
Published: April 2015

AbstractMost diseases exhibit characteristic profiles of cytokine expression, broadly subdivided into Th1, involving primarily cell‐mediated responses, of which Interferon‐gamma (INF‐γ), Interleukin‐2 (IL‐2) and Tumor Necrosis Factor‐alpha (TNF‐α) are hallmarks, and Th2 prcesses, which often involve activation of the humoral arm of the immune system, resulting in elevated levels of IL‐4, IL‐5 and IL‐10. Psoriasis, a disorder chracterized by disfiguring skin lesions and elevated levels of activated CD4+ T helper lymphocytes in both peripheral blood and lesional tissue, exhibits a profile of cytokine expression that includes high levels of TNF‐α and IFN‐γ, with low IL‐5 and IL‐10, indicating that immunologically, the pathogenesis of the disease is Th1.In this study, we report the results of an investigation of peripheral blood mononuclear cell cytokine expression among Kuwaiti psoriasis patients; we demonstrated two patterns of IFN‐γ production which may suggest differing pathogeneses. Whole, haparinized blood was donated by 17 patients with active psoriasis and 11 healthy control subject. Mononuclear cells were isolated by density centrifugation and cultured for 3 days in the presence or absence of a mitogen (PHA). Supernatants were assayed for IFN‐γ (a Th1 marker) and IL‐10 (a Th2 marker) by enzyme‐linked immunoabsorption assay (ELISA). IFN‐γ expression by both PHA‐stimulated and unstimulated cultures from psoriatics significantly exceeded that of controls (p<0.001), whereas no significant differences in IL‐10 expression were noted between psoriatic and control subjects. Stimulation indices (cytokine concentration in PHA‐stimulated/unstimulated cultures, SI) for psoriatic subjects were significantly higher than those of controls for IFN‐γ (p=0.000), but not for IL‐10. Ratios of SI (SI IFN‐γ/SL IL‐10) for the psoriatic subjects also were significantly greater for the psoriatic subjects than for the controls (p=0.003). However, within the psoriatic group, eight patients failed to show the expected elevation of IFN‐γ/IL‐10 ratio as a result of high unstimulated levels of IFN‐γ production. The divergence of IFN‐γ expression within the psoriatic group may indicate two different modes of T lymphocyte activation contributing to the pathogenesis of psoriasis in this study.