bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein kinase C gamma interneurons in the rat medullary dorsal horn: Distribution and synaptic inputs to these neurons, and subcellular localization of the enzyme
Authors: Peirs Cédric , Patil Sudarshan , Bouali‐Benazzouz Rabia , Artola Alain , Landry Marc , Dallel Radhouane 
Published: July 2013

ABSTRACTThe γ isoform of protein kinase C (PKCγ), which is concentrated in interneurons in the inner part of lamina II (IIi) of the dorsal horn, has been implicated in the expression of tactile allodynia. Lamina IIi PKCγ interneurons were shown to be activated by tactile inputs and to participate in local circuits through which these inputs can reach lamina I, nociceptive output neurons. That such local circuits are gated by glycinergic inhibition and that A‐ and C‐fibers low threshold mechanoreceptors (LTMRs) terminate in lamina IIi raise the general issue of synaptic inputs to lamina IIi PKCγ interneurons. Combining light and electron microscopic immunochemistry in the rat spinal trigeminal nucleus, we show that PKCγ‐immunoreactivity is mostly restricted to interneurons in lamina IIi of the medullary dorsal horn, where they constitute 1/3 of total neurons. The majority of synapses on PKCγ‐immunoreactive interneurons are asymmetric (likely excitatory). PKCγ‐immunoreactive interneurons appear to receive exclusively myelinated primary afferents in type II synaptic glomeruli. Neither large dense core vesicle terminals nor type I synaptic glomeruli, assumed to be the endings of unmyelinated nociceptive terminals, were found on these interneurons. Moreover, there is no vesicular glutamate transporter 3‐immunoreactive bouton, specific to C‐LTMRs, on PKCγ‐immunoreactive interneurons. PKCγ‐immunoreactive interneurons contain GABAAergic and glycinergic receptors. At the subcellular level, PKCγ‐immunoreactivity is mostly concentrated on plasma membranes, close to, but not within, postsynaptic densities. That only myelinated primary afferents were found to contact PKCγ‐immunoreactive interneurons suggests that myelinated, but not unmyelinated, LTMRs play a critical role in the expression of mechanical allodynia. J. Comp. Neurol. 522:393–413, 2014. © 2013 Wiley Periodicals, Inc.
Interaction of ZnII Porphyrin with TiO2 Nanoparticles: From Mechanism to Synthesis of Hybrid Nanomaterials
Authors: Spadavecchia Jolanda , Méthivier Christophe , Landoulsi Jessem , Pradier Claire‐Marie 
Published: July 2013

AbstractThe mechanism of interaction of Zn porphyrin (ZnPP) with TiO2 surfaces is investigated with a view to optimizing the synthesis of hybrid nanomaterials. The strategy consists of studying the adsorption of ZnPP on TiO2 flat surfaces by taking advantage of complementary surface characterization techniques. Combining a detailed X‐ray photoelectron spectroscopic analysis with AFM imaging allows ZnPP–surface and ZnPP intermolecular interactions to be discriminated. Probing the adsorption of ZnPP on TiO2 nanoparticles (NPs) reveals the dominant role of ZnPP‐mediated interactions, which are associated with the formation of ZnPP multilayers and/or with the state of aggregation of NPs. These preliminary investigations provide a guideline to synthesizing a novel ZnPP–TiO2 hybrid nanomaterial in a one‐step protocol. In this material, ZnPP molecules are presumably involved in the TiO2 lattice rather than on the NP surface. Furthermore, ZnPP molecules preserve their electronic properties within the TiO2 NPs, and this makes the ZnPP–TiO2 hybrid nanomaterial an excellent candidate for nanomedicine and related applications, such as localization of nanoparticles in cells and tissues or in photodynamic therapy.
Wnt5a evokes cortical axon outgrowth and repulsive guidance by tau mediated reorganization of dynamic microtubules
Authors: Li Li , Fothergill Thomas , Hutchins B. Ian , Dent Erik W. , Kalil Katherine 
Published: July 2013

ABSTRACTWnt5a guides cortical axons in vivo by repulsion and in vitro evokes cortical axon outgrowth and repulsion by calcium signaling pathways. Here we examined the role of microtubule (MT) reorganization and dynamics in mediating effects of Wnt5a. Inhibiting MT dynamics with nocodazole and taxol abolished Wnt5a evoked axon outgrowth and repulsion of cultured hamster cortical neurons. EGFP‐EB3 labeled dynamic MTs visualized in live cell imaging revealed that growth cone MTs align with the nascent axon. Wnt5a increased axon outgrowth by reorganization of dynamic MTs from a splayed to a bundled array oriented in the direction of axon extension, and Wnt5a gradients induced asymmetric redistribution of dynamic MTs toward the far side of the growth cone. Wnt5a gradients also evoked calcium transients that were highest on the far side of the growth cone. Calcium signaling and the reorganization of dynamic MTs could be linked by tau, a MT associated protein that stabilizes MTs. Tau is phosphorylated at the Ser 262 MT binding site by CaMKII, and is required for Wnt5a induced axon outgrowth and repulsive turning. Phosphorylation of tau at Ser262 is known to detach tau from MTs to increase their dynamics. Using transfection with tau constructs mutated at Ser262, we found that this site is required for the growth and guidance effects of Wnt5a by mediating reorganization of dynamic MTs in cortical growth cones. Moreover, CaMKII inhibition also prevents MT reorganization required for Wnt5a induced axon outgrowth, thus linking Wnt/calcium signaling to tau mediated MT reorganization during growth cone behaviors. © 2013 The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc.
Develop Neurobiol 74: 797–817, 2014
HCN1 subunits contribute to the kinetics of Ih in neonatal cortical plate neurons
Authors: Stoenica Luminita , Wilkars Wiebke , Battefeld Arne , Stadler Konstantin , Bender Roland , Strauss Ulf 
Published: July 2013

ABSTRACTThe distribution of ion channels in neurons regulates neuronal activity and proper formation of neuronal networks during neuronal development. One of the channels is the hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channel constituting the molecular substrate of hyperpolarization‐activated current (Ih). Our previous study implied a role for the fastest activating subunit HCN1 in the generation of Ih in rat neonatal cortical plate neurons. To better understand the impact of HCN1 in early neocortical development, we here performed biochemical analysis and whole‐cell recordings in neonatal cortical plate and juvenile layer 5 somatosensory neurons of HCN1−/− and control HCN1+/+ mice. Western Blot analysis revealed that HCN1 protein expression in neonatal cortical plate tissue of HCN+/+ mice amounted to only 3% of the HCN1 in young adult cortex and suggested that in HCN1−/− mice other isoforms (particularly HCN4) might be compensatory up‐regulated. At the first day after birth, functional ablation of the HCN1 subunit did not affect the proportion of Ih expressing pyramidal cortical plate neurons. Although the contribution of individual subunit proteins remains open, the lack of HCN1 markedly slowed the current activation and deactivation in individual Ih expressing neurons. However, it did not impair maximal amplitude/density, voltage dependence of activation, and cAMP sensitivity. In conclusion, our data imply that, although expression is relatively low, HCN1 contributes substantially to Ih properties in individual cortical plate neurons. These properties are significantly changed in HCN1−/−, either due to the lack of HCN1 itself or due to compensatory mechanisms. © 2013 Wiley Periodicals, Inc. Develop Neurobiol 73: 785–797, 2013
Is fat talking a causal risk factor for body dissatisfaction? A systematic review and meta‐analysis
Authors: Sharpe Helen , Naumann Ulrike , Treasure Janet , Schmidt Ulrike 
Published: July 2013

ABSTRACTObjectiveFat talking has been assumed to be a causal risk factor for body dissatisfaction in a number of prevention programs and body confidence campaigns. The aim of this paper was to assess whether fat talking meets three criteria necessary for causal risk factors, namely whether fat talking is: (a) cross‐sectionally associated with body dissatisfaction; (b) prospectively associated with changes in body dissatisfaction; and (c) associated with changes in body dissatisfaction in experimental studies.MethodA systematic literature review was conducted using electronic databases and hand searching of relevant journals. Meta‐analyses provided pooled effect size estimates, and meta‐regressions were used to determine whether age, gender or risk of bias were effect modifiers of the relationship.ResultsSearches revealed 24 studies. There was a significant cross‐sectional association (r = 0.297, 95% CI = 0.225–0.349), which differed in strength between age groups and genders. There was a prospective association between fat talking and changes in body dissatisfaction in long term (r = 0.144, 95% CI = 0.050–0.234), but not in short‐term studies (r = 0.022, 95% CI = −0.131–0.174). One study showed that experimental exposure to fat talking was associated with increases in body dissatisfaction (d = 0.124).DiscussionAs such, there is good evidence that fat talking is a correlate of body dissatisfaction. The few prospective and experimental studies give an initial indication that fat talking is a causal risk factor for body dissatisfaction. Further work is needed to support this position. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:643–652)
Alterations in white matter microstructure in women recovered from anorexia nervosa
Authors: Yau Wai‐Ying Wendy , Bischoff‐Grethe Amanda , Theilmann Rebecca J. , Torres Laura , Wagner Angela , Kaye Walter H. , Fennema‐Notestine Christine 
Published: July 2013

ABSTRACTObjectiveA recent study of ill individuals with anorexia nervosa (AN) reported microstructural alterations in white matter integrity including lower fractional anisotropy and higher mean diffusivity. This study was designed to determine whether such alterations exist in long‐term recovered AN individuals and to examine potential associations with underlying AN traits.MethodTwelve adult women recovered from restricting‐type AN and 10 control women were studied using diffusion tensor imaging.ResultsOverall, there was no significant fractional anisotropy alteration in recovered AN, in contrast to a prior study reporting lower fractional anisotropy in ill AN. Further, recovered AN showed lower mean diffusivity in frontal, parietal and cingulum white matter relative to control women, contrary to elevated mean diffusivity previously reported in ill AN. Lower longitudinal diffusivity in recovered AN was associated with higher harm avoidance. However, more severe illness history was associated with worse white matter integrity after recovery in the same direction as reported in prior work.DiscussionOur findings suggest that fractional anisotropy in recovered AN is not different from controls, however, a novel pattern of lower mean diffusivity was evidenced in recovered AN, and this alteration was associated with harm avoidance. Notably, severity of illness history may have long‐term consequences, emphasizing the importance of aggressive treatment. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:701–708)
Studying the relationship between plant biomass and water use for improved parameterization of plant competition in ecohydrological modelling
Authors: Palanisamy Bakkiyalakshmi , Chui Ting Fong May 
Published: July 2013

ABSTRACTInteraction among plants is one of the major processes that drive the health and management of an ecosystem. Such plant–plant interaction, often expressed in terms of biomass yields observed from field or laboratory experiments, reveals the plants' competitiveness for resources such as water and nutrients. In computational modelling of the coupled changes in hydrology and plant growth, the interaction between plants can be expressed by the competition coefficients in model algorithms such as the Lotka–Volterra system of equations. The competition coefficients determine the plant dynamics and the hydrological processes because vegetation distribution affects the partitioning of water. Therefore, it is imperative to apply appropriate competition coefficients to understand water partitioning by the plants for their growth. For such evaluation of competition coefficients, in this study, we used a coupled groundwater–vegetation predictive model, in which competition coefficients chosen to represent different competitive scenarios were input to simulate the plants' biomass and water use. The simulated biomass and water use were then used to calculate competition coefficients. The results demonstrated that rather than merely confirming the occurrence of competition, neither biomass nor water use measures, by themselves, will be sufficient for describing the entwined relationship that drives the competitive interaction between the plants. We therefore recommend a combined evaluation of both water use and biomass yield for better parameterization of competition coefficients implemented in ecohydrological models. Copyright © 2013 John Wiley & Sons, Ltd.
Can negative mood improve your conversation? Affective influences on conforming to Grice's communication norms
Authors: Koch Alex S. , Forgas Joseph P. , Matovic Diana 
Published: July 2013

AbstractCan temporary mood influence people's communication strategies? According to Grice's cooperative principle, conversational utterances should ideally conform to the maxims of quantity, relevance, quality, and manner. Three experiments predicted and found that participants in a negative mood complied significantly better with Grice's maxims than did participants in a positive mood when using natural language to describe a previously observed social event. Experiments 2 and 3 further confirmed that mood influenced communication strategies, and not merely the encoding (Exp. 2) and retrieval (Exp. 3) of the relevant information. These findings are consistent with affect–cognition theories predicting that positive affect promotes a more internally focused and assimilative thinking and communication style, and negative mood promotes more externally focused and accommodative thinking, resulting in the closer observance of communication norms. The relevance of these findings for recent affect/cognition theories is considered, and the practical implications of the results for everyday conversational strategies are discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Im Zeichen der Armut
Authors: Loiperdinger Martin , Vogl‐Bienek Ludwig 
Published: July 2013

AbstractZwischen medialer Inszenierung und sozialem Abbild: Lichtbilder und Kurzfilme griffen um 1900 in neuer Weise die soziale Frage auf. Nun sind die Bildquellen als digitale Edition für Forschung, Lehre und Öffentlichkeit zugänglich.
Räume, Rechte und Ressourcen
Authors: Baumgart Sabine , Kreibich Volker 
Published: July 2013

AbstractVom System Stadt zum System Megacity: Das Beispiel Dhakas in Bangladesch zeigt, wie Menschen mit Siedlungen an der Stadtperipherie ihr Überleben sichern wollen. Doch die „informelle Urbanisierung”︁ stellt Stadt‐ und Raumplaner vor gewaltige Herausforderungen.
Winzige Saubermacher
Authors: Marx Conrad , Krebs Peter 
Published: July 2013

AbstractSelbstreinigungsprozesse in natürlichen Gewässern können wesentlich verbessert werden, wenn zuvor Mikroorganismen der Abwasserentsorgung in Kläranlagen bedarfsorientiert zugeführt werden. Dies zeigen Studien von Dresdener Forschern. Ob daraus eine neue ökotechnologische Strategie entstehen kann, ist allerdings noch ungewiss.
How do hospitalization experience and institutional characteristics influence inpatient satisfaction? A multilevel approach
Authors: Murante Anna Maria , Seghieri Chiara , Brown Adalsteinn , Nuti Sabina 
Published: July 2013

ABSTRACTOver the last several years, interest in benchmarking health services' quality—particularly patient satisfaction (PS)—across organizations has increased. Comparing patient experiences of care across hospitals requires risk adjustment to control for important differences in patient case‐mix and provider characteristics. This study investigates the individual‐level and organizational‐level determinants of PS with public hospitals by applying hierarchical models. The analysis focuses on the effect of hospital characteristics, such as self‐discharges, on overall evaluations and on across hospital variation in scores. Sociodemographics, admission mode, place of residence, hospitalization ward and continuity of care were statistically significant predictors of inpatient satisfaction. Interestingly, it was observed that hospitals with a higher percentage of Patients Leaving Against Medical Advice (PLAMA) received lower scores. The latter result suggests that the percentage of PLAMA may provide a useful measure of a hospital's inability to meet patient needs and a proxy indicator of PS with hospital care. © 2013 The Authors. International Journal of Health Planning and Management published by John Wiley & Sons, Ltd.
Synthesis of Functionalized Chromenes and Benzofurans from Aryloxy Propargyl Malonates
Authors: Jurberg I. D. , Ikeda K. , Antwi‐Omane D. , Gagosz F. 
Published: July 2013

AbstractA series of aryloxy propargyl malonates was efficiently converted into various chromenes by a gold‐catalyzed cyclization/Brønsted acid catalyzed isomerization sequence, and the chromenes were subsequently converted into benzofurans by implementing an additional photochemical rearrangement. The photochemically induced ring contraction was proven to involve the intermediate formation of dienones.
Social Justice at the Microlevel: Working With Clients' Prejudices
Authors: MacLeod Bailey P. 
Published: July 2013

Social justice is considered the 5th force in counseling and has largely been aimed toward advocating for oppressed individuals and groups by creating change in the societal structures that maintain oppression. However, there is a lack of information for counselors who work with clients who oppress others. This article addresses assessment, conceptualization, and ethical considerations when White clients express racial prejudices in counseling and how it aligns with the goals of social justice.La justicia social está considerada como la 5ª fuerza en la consejería y ha sido dirigida hacia la defensoría de individuos y grupos oprimidos, creando cambios en las estructuras sociales que mantienen la opresión. Sin embargo, hay una carencia de información para consejeros que trabajan con clientes que oprimen a otros. Este artículo trata de la evaluación, conceptualización y consideraciones éticas cuando clientes de raza blanca expresan prejuicios raciales durante la consejería y cómo esto se alinea con los objetivos de la justicia social.
Narrow terahertz attenuation signaturesin Bacillus thuringiensis
Authors: Zhang Weidong , Brown Elliott R. , Viveros Leamon , Burris Kellie P. , Stewart Jr. C. Neal 
Published: July 2013

AbstractTerahertz absorption signatures from culture‐cultivatedBacillusthuringiensiswere measured with a THz photomixing spectrometer operating from 400 to 1200 GHz. We observe two distinct signatures centered at ∼955 and 1015 GHz, and attribute them to the optically coupled particle vibrational resonance (surface phonon‐polariton) ofBacillusspores. This demonstrates the potential of the THz attenuation signatures as “fingerprints” for label‐free biomolecular detection. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Is a fluorescence navigation system with indocyanine green effective enough to detect liver malignancies?
Authors: Tanaka Takayuki , Takatsuki Mitsuhisa , Hidaka Masaaki , Hara Takanobu , Muraoka Izumi , Soyama Akihiko , Adachi Tomohiko , Kuroki Tamotsu , Eguchi Susumu 
Published: July 2013

AbstractBackgroundAlthough several reports have shown the efficacy of a fluorescence navigation system (FNS) with indocyanine green (ICG) to detect liver malignancies during hepatectomy, the real accuracy of this procedure is not yet clear. This study aimed to analyze the actual efficacy of ICG‐FNS in cirrhotic and non‐cirrhotic livers.MethodsTen cirrhotic whole livers explanted from liver transplant recipients and 23 non‐cirrhotic livers from patients who underwent hepatectomy for various kinds of liver tumors were investigated with ICG‐FNS. All surgical specimens were analyzed macroscopically and pathologically.ResultsIn the patients with a cirrhotic liver, most nodules illuminated by ICG‐FNS were diagnosed as regenerative nodules pathologically. The positive predictive value was 5.4%. There was a significant difference in positive predictive value to detect malignant liver tumors between cirrhotic liver and non‐cirrhotic liver (5.4% vs 100%, P < 0.0001). In the non‐cirrhotic livers, 11 of 33 (32.4%) tumors were not recognized by ICG‐FNS through the liver surface before resection. There was a significant difference in the depth from the liver surface to tumor between illuminated nodules and non‐illuminated nodules (1.5 mm vs 11.6 mm, P < 0.01).ConclusionsIt is necessary to know the limitation of ICG‐FNS when detecting liver malignancies in both cirrhotic and non‐cirrhotic livers.
Semi‐analytical non‐charge‐sheet and non‐depletion MOS model, for inversion charge calculation
Authors: Cabré Rodon Roger , Iñiguez Benjamin 
Published: July 2013

ABSTRACTA new computationally implemented semi‐analytic mathematical model is presented to obtain a more accurate estimation of the inversion charge in a MOS structure than standard models. The values of the error of the inversion charge obtained are compared with the assumed ‘exact’ numerical calculated values. These errors are appreciably smaller than the estimation coming from the classical charge‐sheet and depletion approximations. Also the calculation time to obtain the inversion charge is shown to be significantly lower than the numerical one.Because of its accuracy and its relatively low computational speed, the proposed model is a good alternative methodology for the calculation of the inversion charge of MOSFET transistors as a function of their physical features and gate bias voltage. In this sense it should be very useful to be implemented by computer‐aided design integrated circuit simulation software. Copyright © 2013 John Wiley & Sons, Ltd.
Expression of hypoxia inducible factor‐1α and vascular endothelia growth factor in vocal polyps
Authors: Fang Rui , Jiang Jack J. , Smith Benjamin L. , Wu Daquan 
Published: July 2013

Objectives/HypothesisLong‐term vocal overuse or sudden vocal‐fold microvascular disruption may lead to the formation of a hypoxic zone of injury and the subsequent release of a cascade of cytokines in the vocal fold. To test this hypothesis, we investigated the expression and the role of hypoxia inducible factor‐1α (HIF‐1α) and vascular endothelia growth factor (VEGF) in the formation of vocal polyps.MethodsExpression patterns of HIF‐1α and VEGF in surgical specimens of vocal polyps from 36 patients were analyzed using the immunohistochemistry and Western blot method. Normal vocal‐fold mucosa from 26 patients who underwent total laryngectomy were collected and used as the control group.ResultsThe expression of HIF‐1α and VEGF were detected both in the vocal polyps group and the control group, while the expression of HIF‐1α and VEGF levels were significantly higher when compared to normal vocal‐fold mucosa (P < .05).ConclusionThe increased expression of HIF‐1α in vocal polyps indicates that vocal fold overvibration induced hypoxia may play an important role in the pathogenetic mechanism of vocal polyps.Level of EvidenceN/A. Laryngoscope, 123:2184–2188, 2013