bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic analysis of the use of holmium enucleation of the prostate and laparoscopic simple prostatectomy in the surgical treatment of large-volume prostatic hyperplasia
Authors: Volkov S. N. , Pushkar D. Yu. , Kolontarev K. B. , Stepanchenko V. S. , Tereshchenko V. I. , Dzharimok A. R. , Shevyakina A. E. , Daurov M. A. 
Published: July 2024

Introduction. The method of choice for surgical treatment of benign prostatic hyperplasia (BPH) with a volume of more than 80 сс is holmium enucleation of the prostate (HoLEP). However, laser enucleation of the prostate is associated with limitations that carry both a clinical and financial burden. Laparoscopic simple prostatectomy (LSP) has now emerged as an alternative to transurethral procedures. In addition to ensuring clinical efficacy, optimal approaches to surgical management of large-volume BPH must also be financially viable, which underlines the significance of this study.Objective. To conduct a comparative economic analysis of holmium laser enucleation of the prostate and laparoscopic retropubic simple prostatectomy combined with temporary clamping of the internal iliac arteries and vesicourethral anastomosis (LSP + TCA + VUA).Materials & methods. An economic analysis of the results of HoLEP (214 people) and LSP + TCA + VUA (215 people) was conducted in a multicenter, open-label study. The economic analysis aimed to calculate the direct costs associated with surgery, as well as indirect costs related to hospitalization. A comparative analysis of drug prescriptions was conducted, including an assessment of costs for conservative treatment during hospitalization and the postoperative period. The economic losses associated with the duration of patients' temporary disability were calculated as the total loss in gross domestic product (GDP) production.Results. The cost of basic surgical equipment was 15,701,000.0 and 36,927,827.0 rubles (₽) for LSP + TCA + VUA and HoLEP, respectively. The median direct costs for performing LSP + TCA + VUA and laser enucleation HoLEP was 54,990.6 [49,870.5; 67,850.8] and 69,158.9 [65,005.9; 72,351.7] ₽, respectively. The median of indirect costs in the LSP + TCA + VUA and HoLEP groups was 71,251.0 [68,039.0; 73,103.0] and 80,451.0 [74,423.0; 83,501.0] ₽, respectively. The indicators of lost profits in GDP production per person were 5,398.4 and 6,167.9 ₽ in the LSP + TCA + VUA and HoLEP groups, respectively.Conclusion. The rationale for the use of LPA + VPA + UCA in the surgical treatment of large-volume BPH is based on economically justified advantages compared with HoLEP.
Ultrasound-guided renal cavity puncture simulators: comparative characterisation and validation
Authors: Gadjiev N. K. , Mishchenko A. A. , Gorelov D. S. , Britov V. P. , Kharchilava R. R. , Semenyakin I. V. , Petrov S. B. 
Published: July 2024

Introduction. Teaching the skill of renal cavity puncture remains a pressing issue for both resident trainees and practicing physicians. Because patient-based training is ethically questionable and can be unsafe in terms of complications, training models have been created to practice skills.Objective. To compare two non-biological simulators for renal cavity puncture under ultrasound guidance: “UROSON”, GEOTAR, Russia and the kidney phantom “SafeToAct”, Estonia.Materials & methods. The study involved 40 young doctors with no experience in kidney puncture. Group 1 (20 people) practised on the UROSON simulator (GEOTAR, Russia). Group 2 (20 people) trained on a kidney phantom (SafeToAct, Estonia). Both simulators were evaluated by doctors before and after practice, as well as in the long-term period for 3 and 6 months. The assessment was carried out using a Likert scale.Results. The UROSON was rated higher (p < 0.05) according to the results of the comparison of the parameters (colour and consistency, visualisation of the cavity and calyx on ultrasound). Renal cavity visualisation of the UROSON simulator was rated as "good" throughout the study. Visualisation deteriorated by 6.9% after six months of use. Meanwhile, the SafeToAct kidney phantom showed a 64% deterioration in visualisation after one month of use. The SafeToAct kidney phantom was not evaluated later point because it became unusable. Both simulators had "tracks" after punctures. The UROSON had 30% and the SafeToAct kidney phantom 100% (p < 0.0001).Conclusion. The UROSON simulator can be used for training, master classes and accreditation of specialists. This simulator can be used for a long time.
Comparative evaluation of bioavailability of Botulinum toxin A complexed with Tizol (titanium glycerosolvate aquacomplex) versus pure Botulinum toxin A solution for bladder mucosa: an experimental study
Authors: Poroyskiy S. V. , Perlin D. V. , Srussovskaya O. G. , Goncharov N. A. , Kuznetsov A. A. , Morozov E. A. 
Published: July 2024

Introduction. For the treatment of overactive bladder syndrome (OAB), injection of botulinum toxin A (BoNT-A) has been shown to be effective. However, there is a need for a less invasive method for administering BoNT-A, which could significantly expand the treatment options for OAB.Objective. To assess the impact of tizol on the absorption of BoNT-A by the bladder mucosa and compare it to the individual absorption of BoNT-A.Materials & Methods. Dialysis through the mucous membrane of the сalf bladder was used as an experimental model to study changes in bioavailability of BoNT-A complexed with tisol (BoNT-A + T) and pure BoNT-A solution during in vitro experiment. After dialysis, the BoNT-A concentration in both samples was determined using a spectrophotometer. Dialysis curves were plotted according to the data obtained. Kruvchinsky equilibrium dialysis method was used to determine botulinum toxin A bioavailability. The UV spectrophotometry method was used to determine the concentration of BoNT-A in the acceptor medium by reaction of BoNT-A with Benedict's reagent.Results. It was established that the maximum concentration of BoNT-A diffused into the acceptor medium from the blend of the test substance with tizol after nine hours. The area under the curve for dialysis of BoNT-A + T exceeds the area under the curve of pure BoNT-A by almost 20%, suggesting an improvement in the drug's bioavailability when blended with tizol.Conclusion. Based on our experiment, it was found out that the BoNT-A + T has greater bioavailability than a solution of pure BoNT-A. However, the diffusion rate of the component mixture is sufficiently low.
Cultural and Contextual Adaptation of Digital Health Interventions: Narrative Review
Authors: Naderbagi Aila , Loblay Victoria , Zahed Iqthyer Uddin Md , Ekambareshwar Mahalakshmi , Poulsen Adam , Song Yun J C , Ospina-Pinillos Laura , Krausz Michael , Mamdouh Kamel Mostafa , Hickie Ian B , LaMonica Haley M 
Published: July 2024

Background
Emerging evidence suggests that positive impacts can be generated when digital health interventions are designed to be responsive to the cultural and socioeconomic context of their intended audiences.

Objective
This narrative review aims to synthesize the literature about the cultural adaptation of digital health interventions. It examines how concepts of culture and context feature in design and development processes, including the methods, models, and content of these interventions, with the aim of helping researchers to make informed decisions about how to approach cultural adaptation in digital health.

Methods
Literature searches for this narrative review were conducted across 4 databases. Following full-text article screening by 2 authors, 16 studies of interventions predominantly focused on the self-management of health were selected based on their detailed focus on the process of cultural adaptation. Key considerations for cultural adaptation were identified and synthesized through a qualitative narrative approach, enabling an integrative and in-depth understanding of cultural adaptation.

Results
The literature demonstrates varying approaches and levels of cultural adaptation across stages of intervention development, involving considerations such as the research ethos orienting researchers, the methodologies and models used, and the resultant content adaptations. In relation to the latter, culturally appropriate and accessible user interface design and translation can be seen as particularly important in shaping the level of adaptation.

Conclusions
Optimizing cultural adaptation involves linking culture with other contextual factors such as economic conditions and social systems to ensure accessibility and the sustained use of digital health interventions. Culturally humble approaches that use the involvement of a broad range of participants, experts, and other stakeholders are demonstrated to spark vital insights for content development, implementation, and evaluation.
Overdose Detection Among High-Risk Opioid Users Via a Wearable Chest Sensor in a Supervised Injecting Facility: Protocol for an Observational Study
Authors: Tas Basak , Lawn Will , Jauncey Marianne , Bartlett Mark , Dietze Paul , O'Keefe Daniel , Clark Nico , Henderson Bruce , Cowan Catriona , Meredith Osian , Strang John 
Published: July 2024

Background
Opioid overdose is a global health crisis, affecting over 27 million individuals worldwide, with more than 100,000 drug overdose deaths in the United States in 2022-2023. This protocol outlines the development of the PneumoWave chest biosensor, a wearable device being designed to detect respiratory depression in real time through chest motion measurement, intending to enhance early intervention and thereby reduce fatalities.

Objective
The study aims to (1) differentiate opioid-induced respiratory depression (OIRD) from nonfatal opioid use patterns to develop and refine an overdose detection algorithm and (2) examine participants’ acceptability of the chest biosensor.

Methods
The study adopts an observational design over a 6-month period. The biosensor, a small device, will be worn by consenting participants during injecting events to capture chest motion data. Safe injecting facilities (SIF) in Melbourne, Victoria (site 1), and Sydney, New South Wales (site 2), which are legally sanctioned spaces where individuals can use preobtained illicit drugs under medical supervision. Each site is anticipated to recruit up to 100 participants who inject opioids and attend the SIF. Participants will wear the biosensor during supervised injecting events at both sites. The biosensor will attempt to capture data on an anticipated 40 adverse drug events. The biosensor’s ability to detect OIRD will be compared to the staff-identified events that use standard protocols for managing overdoses. Measurements will include (1) chest wall movement measured by the biosensor, securely streamed to a cloud, and analyzed to refine an overdose detection algorithm and (2) acute events or potential overdose identified by site staff. Acceptability will be measured by a feedback questionnaire as many times as the participant is willing to throughout the study.

Results
As of April 2024, a total of 47 participants have been enrolled and data from 1145 injecting events have already been collected, including 10 overdose events. This consists of 17 females and 30 males with an average age of 45 years. Data analysis is ongoing.

Conclusions
This protocol establishes a foundation for advancing wearable technology in opioid overdose prevention within SIFs. The study will provide chest wall movement data and associated overdose data that will be used to train an algorithm that allows the biosensor to detect an overdose. The study will contribute crucial insights into OIRD, emphasizing the biosensor’s potential step forward in real-time intervention strategies.

International Registered Report Identifier (IRRID)
DERR1-10.2196/57367
Sodium Bicarbonate Treatment and Clinical Outcomes in Chronic Kidney Disease with Metabolic Acidosis
Authors: Yang Ting-Ya , Lin Hong-Min , Wang Hsien-Yi , Chuang Min-Hsiang , Hsieh Chia-Chen , Tsai Kang-Ting , Chen Jui-Yi 
Published: July 2024

Key PointsSodium bicarbonate for patients with CKD and metabolic acidosis leads to a significant improvement in kidney function.Treatment with sodium bicarbonate increases in mid-arm muscle circumference, indicating a positive effect on enhancing muscle mass.Sodium bicarbonate supplementation is associated with a higher risk of elevated systolic BP, marking a potential side effect.BackgroundIn patients with CKD, impaired kidney acid excretion leads to the onset of metabolic acidosis (MA). However, the evidence is not yet conclusive regarding the effects of sodium bicarbonate in treating CKD with MA.MethodsDatabases with PubMed, Embase, and the Cochrane Library were used to search for randomized controlled trials (RCTs) from the inception until November 11, 2023, to identify RCTs investigating the effect of sodium bicarbonate in participants with CKD and MA. The primary outcome was the change in eGFR. Secondary outcomes included hospitalization rates, change in systolic BP, all-cause mortality, and mid-arm muscle circumference. A random-effects model was applied for analysis, and subgroup, sensitivity analyses were also performed.ResultsFourteen RCTs comprising 2037 patients demonstrated that sodium bicarbonate supplementation significantly improved eGFR (standardized mean difference [SMD], 0.33; 95% confidence interval [CI], 0.03 to 0.63;P= 0.03). The group receiving sodium bicarbonate had a lower hospitalization rate (odds ratio, 0.37; 95% CI, 0.25 to 0.55;P< 0.001). Higher mid-arm muscle circumference was observed with sodium bicarbonate treatment compared with those without (SMD, 0.23; 95% CI, 0.08 to 0.38;P= 0.003, I2<0.001). However, higher risk of elevated systolic BP was found with sodium bicarbonate treatment (SMD, 0.10; 95% CI, 0.01 to 0.20;P= 0.03). No significant difference in all-cause mortality was noted.ConclusionsIn patients with CKD and MA, sodium bicarbonate supplementation may provide potential benefits in preventing the deterioration of kidney function and increasing muscle mass. However, treatment may be associated with higher BP. Owing to the risk of bias stemming from the absence of double-blinded designs and inconsistencies in control group definitions across the studies, further research is crucial to verify these findings.
Strategy of local government in achieving the target of the long-term contraceptive method program in sukabumi City
Authors: Wahyuni Tantri Sri , Purwanti Dian , Basori Yana Fajar FY 
Published: July 2024

Long-Term Contraceptive Method is a contraceptive that can be used for a long time, which is more than three years used to delay, minimize pregnancy, and stop fertility, which includes IUD, Implant and steady contraception, this study aims to determine the factors associated with the use of Long-Term Contraceptive Method in Sukabumi City. The purpose of this study is to determine the strategy of the Office of Population Control, Family Planning, Women's Empowerment and Child Protection (DP2KBP3A) in achieving the target of the long-term contraceptive method program in Sukabumi City. This study used descriptive qualitative methods with observational data collection techniques, interviews and documentation. Data analysis was carried out by snowball sampling technique, namely by determining informants who were initially small in number and then enlarged. The results of this study measured by strategy indicators by Mintzberg et al (2003) show that the Agency in achieving the targets of the MKJP program begins with planning, implementing and evaluating. However, in the implementation there are still some obstacles. Existing programs have helped in the process of implementing long-term contraceptive method programs. But not yet fully optimized. Therefore, it is necessary to expand the range of strategies, so that the program of long-term contraceptive methods is maximized.
Animasi Beladiri Judo Low Polygon Menggunakan Kinect
Authors: ACHMADI RIZQI NIDZAR , Cahyono Eko Budi , Husniah Lailatul 
Published: July 2024

Animasi merupakan sebuah proses yang dilakukan untuk menghiupkan sebuah benda mati melalui proses ilusi gerakan dari gambar statis yang dilakukan sedikit demi sedikit hingga memiliki kesan benda mati tersebut hidup. Penelitian ini dilakukan dengan tujuan menganimasikan gerakan bantingan beladiri Judo dengan menggunakan model 3D Low Polygon. Proses animasi menggunakan 2 kamera Kinect v1 yang diposisikan dengan sudut 60-90° dan posisi kamera 180° terhadap aktor. Gerakan animasi motion capture memiliki ketidakakuratan pada posisi kamera 60-90° terhadap aktor. Hasil gerakan animasi motion capture dengan posisi kamera 180° terhadap aktor dapat diterapkan pada model 3D dengan hasil yang baik. Dengan penelitian ini diharapkan bisa menjadi acuan untuk perbaikan teknik motion capture gerakan bantingan beladiri Judo secara lebih baik.
Perbandingan Metode Klasifikasi Berita Hoaks Berbahasa Indonesia Berbasis Pembelajaran Mesin
Authors: Athaillah Muhammad , Azhar Yufis , Munarko Yuda 
Published: July 2024

Klasifiaksi berita hoaks merupakan salah satu aplikasi kategorisasi teks. Berita hoaks harus diklasifikasikan karena berita hoaks dapat mempengaruhi tindakan dan pola pikir pembaca. Dalam proses klasifikasi pada penelitian ini menggunakan beberapa tahapan yaitu praproses, ekstraksi fitur, seleksi fitur dan klasifikasi. Penelitian ini bertujuan membandingkan dua algoritma yaitu algoritma Naïve Bayes dan Multinomial Naïve Bayes, manakah dari kedua algoritma tersebut yang lebih efektif dalam mengklasifikasikan berita hoaks. Data yang digunakan dalam penelitian ini berasal dari www.trunbackhoax.id untuk data berita hoaks sebanyak 100 artikel dan data berita non-hoaks berasal dari kompas.com, detik.com berjumlah 100 artikel. Data latih berjumlah 140 artikel dan data uji berjumlah 60 artikel. Hasil perbandingan algoritma Naïve Bayes memiliki nilai F1-score sebesar 0,93 dan nilai F1-score Multinomial Naïve Bayes sebesar 0,92.
Pembuatan Jadwal Shift Perawat Dengan Menggunakan Metode Constraint Satisfaction
Authors: Mustafa Rizal Rakhman , Azhar Yufis , Hayatin Nur 
Published: July 2024

Rumah Sakit adalah institusi pelayanan kesehatan yang menyelenggarakan pelayanan kesehatan perorangan secara paripurna yang menyediakan pelayanan rawat inap, rawat jalan dan gawat darurat. Rumah Sakit mempunyai beberapa Sumber daya dari suatu fasilitas kesehatan seperti, perawat, dokter dan peralatan medis harus tersedia selama 24 jam sehari dalam satu minggu. Bagi perawat panjangnya jam kerja dapat berdampak buruk pada pelayanan kesehatan dan kualitas kerja, oleh sebab itu penjadwalan merupakan hal yang sangat penting dan membatu perawatan dalam meningkatkan pelayanan kesehatan dan kualitas kerja. Penjadwalan ini diharapkan dapat membatu kepala ruang untuk mendapatkan jadwal dengan beban jam kerja lebih efektif untuk setiap perawat serta memenuhi batasan - batasan penjadwalan yang ada. Constraint Programing (CP) merupakan pendekatan perhitungan atau komputasi matematis atas masalah - masalah yang berkaitan dengan batasan – batasan dari variabel – variabel, dengan tujuan mencari solusi yang memenuhi batasan – batasan tersebut. Setelah melakukan evaluasi terhadap penelitian ini, dapat disimpulkan bahwa penggunaan algoritma Constraint Satisfaction untuk pembuatan jadwal shift perawat ini dinilai cukup efektif. Keberhasilan dalam penjadwalan ini mencapai 99.2% dan 94%.
Sistem Informasi Distribusi Tenaga Kerja (Studi Kasus PT Sodo Sakti Jaya)
Authors: Rachmanu Andi Mochlis , Maskur Maskur , Suharso Wildan 
Published: July 2024

Tenaga kerja Indonesia adalah warga Negara Indonesia laki-laki maupun wanita yang sedang berkerja di luar negeri. Tenaga kerja Indonesia memiliki jangka waktu kerja yang sudah ditentukan berdasarkan perjanjian kerja yang sudah disepakati. Sebelum berangkat keluar negeri diperlukan jasa penyalur pemberangkatan tenaga kerja untuk berkerja ke luar negeri. PT Sodo Sakti Jaya adalah sebuah perusahaan yang berjalan di bidang jasa pemberangkatan dan penyalur untuk tenaga kerja yang akan berkerja di luar negeri ( Hongkong, Singapura, Malaysia, dan Taiwan ). Sebagai penyedia jasa, PT Sodo Sakti Jaya menangani persyaratan tenaga kerja sebelum berangkat berkerja ke luar negeri. Persyaratan tersebut antara lain data kesehatan, BLK-LN, wawancara, kontrak kerja, rekan kerja yang bertanggung jawab di luar negeri dan keberangkatan tenaga kerja. Pada tugas akhir ini dirancang Sistem Informasi Distribusi Tenaga Kerja berbasis website untuk mempermudah perusahaan dalam informasi tenaga kerja yang berada di luar negeri dan pengelolaan data bagi PT Sodo Sakti Jaya. Perusahaan yang semula kesulitan dalam melakukan pemantauan tenaga kerja dengan adanya sistem ini pihak perusahaan pemantauan data rekan kerja, ujian tenaga kerja, persyaratan tenaga kerja, tenaga kerja yang sudah berangkat ke luar negeri dapat dilakukan melalui website. Pegawai juga dapat mencetak laporan keberangkatan tenaga kerja, membuat jadwal ujian dan keberangkatan yang ditujukan kepada tenaga kerja dengan melalui website dengan mudah dan cepat. Hal ini terbukti dengan sudah dilakukan pengujian sistem yang dilakukan oleh pihak PT Sodo Sakti Jaya dengan nilai 90% keatas.
Analisis Maturity Level Layanan dan Produktivitas Sumber Daya Manusia berdasarkan Business Goal 15 COBIT 4.1 (Studi Kasus : Dinas Komunikasi dan Informatika Provinsi Jawa Timur)
Authors: Nandhany Cyndya , Mukaromah Siti , Pratama Arista 
Published: July 2024

Dinas Komunikasi dan Informatika (Diskominfo) Provinsi Jawa Timur merupakan salah satu instansi pemerintah di Provinsi Jawa Timur yang berperan membantu Gubernur Provinsi Jawa Timur dalam menyiapkan bahan yang diperlukan dalam pemerintahan pada bidang komunikasi dan informasi dalam lingkup provinsi Jawa Timur. Penyebarluasan informasi dan pelayanan publik melalui Teknologi Informasi dan Komunikasi (TIK) di Jawa Timur merupakan tugas utama Diskominfo Provinsi Jawa Timur. Berdasarkan data struktural, hasil observasi, dan penelitian terdahulu diperoleh bahwa mayoritas jumlah staf merupakan Aparatur Sipil Negara (ASN) yang berasal dari instansi pemerintah lain sehingga terbatasnya pemahaman terhadap urgensi dan perkembangan TI, sistem informasi belum sepenuhnya terintegrasi karena minim pemberdayaan sumber daya manusia dan pengembangan sistem membutuhkan pihak ketiga, serta pembagian tugas pokok pegawai belum dibagi secara merata, maka diperlukan analisis maturity level. Penelitian ini bertujuan untuk menganalisis maturity level layanan dan produktivitas sumber daya manusia pada Diskominfo Procinsi Jawa Timur. Pelitian dilaksanakan dengan melakukan observasi, studi literatur, penentuan business goal, pengumpulan data bukti melalui wawancara, penentuan dan analisis maturity level, serta penentuan hasil temuan beserta rekomendasi. Layanan dan produktivitas sumber daya manusia berkaitan erat dengan Business Goal 15 pada perspektif internal COBIT 4.1 tentang meningkatkan dan menjaga produktivitas operasional dan staf. Hasil pengukuran maturity level menunjukan bahwa layanan dan produktivitas sumber daya manusia pada Diskominfo Provinsi Jawa Timur sebesar 3,005477646 yaitu pada level 3 (defined), yang berarti telah didefinisikan kebijakan dan pelaksanaan standarisasi terhadap proses-proses penting seperti arsitektur informasi, infrastruktur TI, pelatihan dan pendidikan pengguna, serta manajemen layanan/insiden, meski belum bersifat formal dan menyeluruh.