bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating youth participatory action research and health communication to inform youth and young adult covid-19 vaccine communication research
Authors: Kikut-Stein Ava , Givan Kathleen , Fishman Jeffrey , Blanco-Liz Ashley , Alvarez-Sanchez David , Fletcher Janelle , Gambrell Raki , Hernandez Alondra , Richardson Ciani , Shaw Adrianna , von Oiste James Joseph 
Published: August 2024

Abstract
COVID-19 vaccination rates remain lower among adolescents compared with adults. Youth participatory action research (YPAR) offers opportunities to inform youth vaccine communication at the local and population level. However, few studies have integrated systematic health communication research with YPAR. In the current study, a diverse team of paid high school interns, undergraduate student mentors and communication researchers in West Philadelphia YPAR programs developed a theory-informed communication survey to measure teen COVID-19 vaccine beliefs, information sources and behavior. The survey was distributed locally and informed youth-created vaccine campaign messages. In addition, YPAR-derived survey measures complimented a qualitative online elicitation survey with US young adults. Responses were coded using inductive content analysis, informing measures for a subsequent population-level study of young adults. This research followed protocols approved by an Institutional Review Board. Applying a YPAR framework elevated youth voices in the study development process. Communication theory and methods aided the development of survey studies to advance both local YPAR program objectives and population-level research. Future implications are discussed.
Colombia as the ‘Laboratory’ for Transitional Justice: Consolidation and Innovation of Global Formulas
Authors: Jespersgaard Jakobsen Line 
Published: August 2024

ABSTRACT∞
This article examines the standardization of transitional justice, using Colombia—regarded by international observers as a contemporary laboratory—as a case. It investigates the extent to which transitional justice, as a global blueprint for addressing past atrocities, is being embraced in Colombia and how Colombian experiences contribute to both innovation and advancement of transitional justice internationally. Colombia offers a unique perspective on how transitional justice experts and institutions engage in and construct national, regional and international networks experimentally, under the guidance of international lab certifiers and informal standardizers. Drawing on a study focused on the justice pillar of transitional justice, the article argues that the significant level of local agency, coupled with international recognition and involvement, has contributed to strengthening, rather than weakening, the international transitional justice standard through innovation and localization.
Leveraging Data From a Longitudinal Birth Cohort to Improve Attribution of Diarrhea Etiology Among Children in Low-Resource Settings
Authors: Garcia Quesada Maria , Platts-Mills James A , Liu Jie , Houpt Eric R , Rogawski McQuade Elizabeth T 
Published: August 2024

Abstract
Attributing infectious causes of diarrhea is critical to inform treatment and burden estimates. The attributable fraction (AF) approach based on the association between pathogen quantity and diarrhea has been frequently used but may underestimate incidence. We leveraged data from the multisite birth-cohort Malnutrition and Enteric Disease (MAL-ED) Study, where diarrheal and nondiarrheal stools were collected from 1715 children aged 0–2 years. We compared attribution using a longitudinal AF method that considers the temporal association between pathogen quantity and diarrhea symptoms to previously published AF estimates. For rotavirus and Shigella, attribution did not meaningfully change. For others like adenovirus 40 and 41, astrovirus, norovirus GII, sapovirus, Campylobacter jejuni or Campylobacter coli, heat-stable toxin enterotoxigenic Escherichia coli, typical enteropathogenic E. coli, and Cryptosporidium attribution increased, demonstrating longitudinal data may be informative for pathogens with weak associations between quantity and diarrhea. We further derived accuracy-based, pathogen-specific quantity cutoffs that may improve attribution in the absence of longitudinal data.
Temperature-dependent trophic associations modulate soil bacterial communities along latitudinal gradients
Authors: Huang Xing , Wang Jianjun , Dumack Kenneth , Anantharaman Karthik , Ma Bin , He Yan , Liu Weiping , Di Hongjie , Li Yong , Xu Jianming 
Published: August 2024

Abstract
Understanding the environmental and biological mechanisms shaping latitudinal patterns in microbial diversity is challenging in the field of ecology. Although multiple hypotheses have been proposed to explain these patterns, a consensus has rarely been reached. Here, we conducted a large-scale field survey and microcosm experiments to investigate how environmental heterogeneity and putative trophic interactions (exerted by protist–bacteria associations and T4-like virus–bacteria associations) affect soil bacterial communities along a latitudinal gradient. We found that the microbial latitudinal diversity was kingdom dependent, showing decreasing, clumped, and increasing trends in bacteria, protists, and T4-like viruses, respectively. Climatic and edaphic drivers played predominant roles in structuring the bacterial communities; the intensity of the climatic effect increased sharply from 30°N to 32°N, whereas the intensity of the edaphic effect remained stable. Biotic associations were also essential in shaping the bacterial communities, with protist–bacteria associations showing a quadratic distribution, whereas virus–bacteria associations were significant only at high latitudes. The microcosm experiments further revealed that the temperature component, which is affiliated with climate conditions, is the primary regulator of trophic associations along the latitudinal gradient. Overall, our study highlights a previously underestimated mechanism of how the putative biotic interactions influence bacterial communities and their response to environmental gradients.
Towards cross-application model-agnostic federated cohort discovery
Authors: Dobbins Nicholas J , Morris Michele , Sadhu Eugene , MacFadden Douglas , Nazaire Marc-Danie , Simons William , Weber Griffin , Murphy Shawn , Visweswaran Shyam 
Published: August 2024

Abstract

Objectives
To demonstrate that 2 popular cohort discovery tools, Leaf and the Shared Health Research Information Network (SHRINE), are readily interoperable. Specifically, we adapted Leaf to interoperate and function as a node in a federated data network that uses SHRINE and dynamically generate queries for heterogeneous data models.

Materials and Methods
SHRINE queries are designed to run on the Informatics for Integrating Biology & the Bedside (i2b2) data model. We created functionality in Leaf to interoperate with a SHRINE data network and dynamically translate SHRINE queries to other data models. We randomly selected 500 past queries from the SHRINE-based national Evolve to Next-Gen Accrual to Clinical Trials (ENACT) network for evaluation, and an additional 100 queries to refine and debug Leaf’s translation functionality. We created a script for Leaf to convert the terms in the SHRINE queries into equivalent structured query language (SQL) concepts, which were then executed on 2 other data models.

Results and Discussion
91.1% of the generated queries for non-i2b2 models returned counts within 5% (or ±5 patients for counts under 100) of i2b2, with 91.3% recall. Of the 8.9% of queries that exceeded the 5% margin, 77 of 89 (86.5%) were due to errors introduced by the Python script or the extract-transform-load process, which are easily fixed in a production deployment. The remaining errors were due to Leaf’s translation function, which was later fixed.

Conclusion
Our results support that cohort discovery applications such as Leaf and SHRINE can interoperate in federated data networks with heterogeneous data models.
Ciliary length variations impact cilia-mediated signaling and biological responses
Authors: Kobayashi Yuki , Hamamoto Akie , Saito Yumiko 
Published: August 2024

Abstract
Primary cilia are thin hair-like organelles that protrude from the surface of most mammalian cells. They act as specialized cell antennas that can vary widely in response to specific stimuli. However, the effect of changes in cilia length on cellular signaling and behavior remains unclear. Therefore, we aimed to characterize the elongated primary cilia induced by different chemical agents, lithium chloride (LiCl), cobalt chloride (CoCl2) and rotenone, using human retinal pigmented epithelial 1 (hRPE1) cells expressing ciliary G protein-coupled receptor (GPCR), melanin-concentrating hormone (MCH) receptor 1 (MCHR1). MCH induces cilia shortening mainly via MCHR1-mediated Akt phosphorylation. Therefore, we verified the proper functioning of the MCH-MCHR1 axis in elongated cilia. Although MCH shortened cilia that were elongated by LiCl and rotenone, it did not shorten CoCl2-induced elongated cilia, which exhibited lesser Akt phosphorylation. Furthermore, serum readdition was found to delay cilia shortening in CoCl2-induced elongated cilia. In contrast, rotenone-induced elongated cilia rapidly shortened via a chopping mechanism at the tip of the cilia. Conclusively, we found that each chemical exerted different effects on ciliary GPCR signaling and serum-mediated ciliary structure dynamics in cells with elongated cilia. These results provide a basis for understanding the functional consequences of changes in ciliary length.
Effects of female-specific selection for reproductive investment on male fertility traits
Authors: Mason Chloe , Tschirren Barbara , Hemmings Nicola 
Published: August 2024

Abstract
Despite sharing an autosomal genome, the often divergent reproductive strategies of males and females cause the selection to act in a sex-specific manner. Selection acting on one sex can have negative, positive, or neutral fitness consequences on the opposite sex. Here, we test how female-limited selection on reproductive investment in Japanese quail (Coturnix japonica) affects male fertility-related traits. Despite there being no difference in the size of males’ testes from lines selected for high female reproductive investment (H-line) or low female reproductive investment (L-line), in both lines, the left testis had a greater volume of sperm-producing tissue. Since H-line females have a larger left-side restricted oviduct, this suggests a positive genetic correlation between male and female gonad function and that internal testis structure is a target of sexual selection. However, despite H-line males having previously been found to have greater fertilization success in a competitive scenario, we found little evidence of a difference between the lines in sperm number, motility, velocity, length, or the number of sperm that reached the ova. Precopulatory cues and/or the role of seminal fluid in sperm motility may thus be more likely to contribute to the H-line male fertilization advantage in this species.
Efficacy of plant-based products and nonconventional pesticides for the management of tropical bed bug
Authors: Meisyara Dita , Guswenrivo Ikhsan , Veera Singham G 
Published: August 2024

Abstract
Insecticide resistance is widespread in global bed bug populations. Both common bed bugs and tropical bed bugs are pyrethroid-resistant among most field populations. Plant-based products and nonconventional pesticides offer minimal-risk strategies for managing bed bug resistance, but this strategy has yet to be formally evaluated in Cimex hemipterus (F.) (Hemiptera: Cimicidae). Here, several commercial plant-based formulations (Cedarcide, EcoRaider (also known as EcoVenger), EcoSMART, and Bio-D), a novel product, Provecta, and a pyrethroid insecticide, Pesguard FG161 were tested against pyrethroid-susceptible and resistant strains of C. hemipterus using direct spray, residual exposure, and egg dipping assays. Direct spray treatments outperform residual applications against all tested bed bug strains. Cedarcide exhibits the highest consistency in eliminating bed bugs, followed by EcoRaider, EcoSMART, and Provecta that outperform Bio-D and Pesguard FG161. In comparison to Pesguard FG161, all plant-based insecticide products and Provecta showed higher efficacy against pyrethroid-resistant strains. Although effective, product efficacy varies in terms of speed. Cedarcide kills all bed bugs within 1 min after spraying; however, other products can take up to 9 days to achieve 100% mortality. The efficacy of all products was reduced when evaluated on fabric surface (42%–65% mortality). Cedarcide and EcoRaider reduced egg hatchability by 37%–73% and 47%–70%, respectively. This study suggests that certain plant-based insecticides and an unconventional insecticide can serve as alternative direct spray treatments for managing tropical bed bugs, though their residual effects are limited.
STING coordinates resolution of inflammation during wound repair by modulating macrophage trafficking through STAT3
Authors: Chen Cheng , Cai Xin , Liu Zhihui , Zhang Weiguang , Yang Jiacai , Tang Yuanyang , Chen Yunxia , Huang Yong , Hu Wengang , Zhang Xiaorong , Zhou Junyi , Wu Yanjun , Yin Wenjing , Shang Ruoyu , Lu Qudong , Sheng Hao , Ju Zhenyu , Luo Gaoxing , He Weifeng 
Published: August 2024

Abstract
Efficient cutaneous wound healing requires a coordinated transition between inflammatory phases mediated by dynamic changes in leukocyte subset populations. Here, we identify STING as a key innate immune mediator governing timely resolution of inflammation by regulating macrophage dynamics during skin repair. Using a mouse model, we show STING deficiency caused delayed wound closure associated with abnormal persistence of TNF-α+ leukocytes. This resulted from the impaired macrophage recruitment. STING controlled the trafficking of bone marrow myeloid cells into blood and wounds, intrinsically enhancing macrophage migratory capacity through STAT3 activation. Specifically, STING modulated the production of monocyte chemokines and their receptors CCR2/CCR5 to enable efficient egress and wound infiltration. Consequently, disrupted systemic and local STING–STAT3–chemokine signaling combine to delay macrophage influx. This study elucidates STING as a critical rheostat tuning macrophage responses through STAT3 to orchestrate inflammatory resolution necessary for efficient wound healing. Our findings have broad implications for targeting STING therapeutically in both regenerative medicine and inflammatory disease contexts.
Women hold up the shattering sky? Performance feedback on multiple conflicting goals and women’s representation in top management teams in the public sector
Authors: Huang Ting 
Published: August 2024

Abstract
Previous research on the glass cliff phenomenon has primarily explored the impact of performance decline on women in leadership based on single objectives, overlooking the complexity of managing performance in the public sector. This study adopts a multigoal perspective to explore how performance feedback in a dual-goal scenario affects gender composition in top management teams (TMTs) in Chinese local governments. Drawing on behavioral theory, it differentiates between unambiguous and ambiguous feedback as two distinct types of organizational performance feedback, to test their influence on women’s proportion in TMTs. A unique data set covering 276 Chinese municipal governments from 2010 to 2018 was used to investigate how performance feedback on two conflicting objectives, economic growth and environmental protection pursued by Chinese local governments, affects women’s proportion in mayoral teams. Results from fractional logit regression suggest that unambiguous failure is positively associated with the proportion of women in TMTs. However, ambiguous performance feedback is negatively related to the proportion of women in TMTs. Implications for research on gender composition in the upper echelons and performance feedback on multiple objectives are discussed.
Obligatory Implicatures and the Relevance of Contradictions
Authors: Bar-Lev Moshe E 
Published: August 2024

Abstract
Magri (2009a,b) proposed a generalization according to which a sentence is infelicitous whenever exhaustification over the full set of formal alternatives of the sentence leads to contextual contradiction. While Magri proposes an account of obligatory implicatures which explains some cases where this generalization expects infelicity, he does not provide a general account of this generalization. In this paper I argue for a perspective on the ‘pruning’ of alternatives which predicts this generalization, building on the counter-intuitive idea that contradictions are relevant in every context (Lewis 1988). I further argue, using disjunction in the scope of a universal quantifier as a test case, that an extension of this view to obligatory ignorance inferences provides a new perspective on the Logical Integrity Generalization put forward by Anvari (2018b), while avoiding some empirical problems for this generalization.
External jugular venous aneurysm—a case report
Authors: Sogandji Nihal , La Torre Guglielmo , Hildebrand Diane 
Published: August 2024

Abstract
Aneurysms of the external jugular vein (EJV) are uncommon vascular malformations. Due to their rarity, it is currently unclear what the risk of complications are and whether surgical management should be offered. The risks associated with the surgery need to be balanced with the risk of complications from the malformation. We present the case of a young woman who presented with a painful erythematous neck swelling who was found to have an aneurysm of the EJV with thrombophlebitis. This was successfully treated with surgical excision. We discuss current evidence for treatment of neck vein aneurysms and pitfalls.
The Cosmopolitans: Cocktail Culture, Gender, and Social Status in Interwar Singapore
Authors: Lowrie Claire , Samuelsson Lauren 
Published: August 2024

Abstract
This article explores the emergence of cocktail culture in interwar Singapore. Mixed alcoholic drinks were consumed by British men in Singapore from at least the 1910s, including the famous “Singapore Sling.” However, it was not until the 1920s that cocktails became the drink of choice for elite men and women from Singapore’s Chinese, British, and Eurasian communities. The consumption of American popular culture and exchange with American colonists in the Philippines helped the cocktail to become a symbol of tropical modernity. At the same time, the possibilities of home entertaining were transformed by the increasing availability of American-made domestic refrigerators in Singapore from the mid-1920s. Multiethnic elites, accustomed to frequenting bars and cafés to enjoy cocktails, began to host their own cocktail parties with the help of their Chinese servants. The interwar cocktail party offered the wealthy a means to display conspicuous consumption and cosmopolitan modernity. They did so in a way that unsettled but did not overturn colonial hierarchies based on gender, race, and class.
The concerted function of a novel class of transcription factors, ZBFs, in light, jasmonate, and abscisic acid signaling pathways
Authors: Dutta Siddhartha , Chattopadhyay Sudip , Maurya Jay Prakash 
Published: August 2024

Abstract
Several classes of transcription factors have been investigated in light signaling pathways that bind to the light-responsive elements (LREs) present in the promoters of light regulatory genes for transcriptional regulation. Some of these transcription factors have been shown to bind to numerous promoters through genome-wide ChIP-on-chip (ChIP-chip) studies. Furthermore, through the integration of ChIP-seq and RNA-seq techniques, it has been demonstrated that a transcription factor modifies the expression of numerous genes with which it interacts. However, the mode of action of these transcription factors and their dependency on other regulators in the pathway has just started to be unraveled. In this review, we focus on a particular class of transcription factors, ZBFs (Z-box-binding factors), and their associated partners within the same or other classes of transcription factors and regulatory proteins during photomorphogenesis. Moreover, we have further made an attempt to summarize the crosstalk of these transcription factors with jasmonic acid-, abscisic acid-, and salicylic acid-mediated defense signaling pathways. This review offers an in-depth insight into the manner in which ZBFs and their interactors reshape cellular functions and plant behavior. The underlying principles not only contribute to a comprehensive understanding but also establish a framework for analyzing the interplay between early developmental events and hormone signaling, a regulation orchestrated by the ZBF family.
Shedding light on iron nutrition: exploring intersections of transcription factor cascades in light and iron deficiency signaling
Authors: Trofimov Ksenia , Mankotia Samriti , Ngigi Mary , Baby Dibin , Satbhai Santosh B , Bauer Petra 
Published: August 2024

Abstract
In the dynamic environment of plants, the interplay between light-dependent growth and iron nutrition is a recurring challenge. Plants respond to low iron levels by adjusting growth and physiology through enhanced iron acquisition from the rhizosphere and internal iron pool reallocation. Iron deficiency response assays and gene co-expression networks aid in documenting physiological reactions and unraveling gene-regulatory cascades, offering insight into the interplay between hormonal and external signaling pathways. However, research directly exploring the significance of light in iron nutrition remains limited. This review provides an overview on iron deficiency regulation and its cross-connection with distinct light signals, focusing on transcription factor cascades and long-distance signaling. The circadian clock and retrograde signaling influence iron uptake and allocation. The light-activated shoot-to-root mobile transcription factor ELONGATED HYPOCOTYL5 (HY5) affects iron homeostasis responses in roots. Blue light triggers the formation of biomolecular condensates containing iron deficiency-induced protein complexes. The potential of exploiting the connection between light and iron signaling remains underutilized. With climate change and soil alkalinity on the rise, there is a need to develop crops with improved nutrient use efficiency and modified light dependencies. More research is needed to understand and leverage the interplay between light signaling and iron nutrition.