bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of maternal mortality and stillbirth in feline dystocia after emergency obstetric care interventions: a retrospective analysis
Authors: Sendag Sait , Hardegen Doreen , Koca Davut , Wehrend Axel 
Published: February 2025

Objectives The aim of this study was to investigate the efficacy and success of emergency obstetric care interventions for feline dystocia and to analyse the effects of therapeutic interventions on maternal mortality and stillbirth. Methods This retrospective, observational study included 153 queens of various breeds and ages that presented to the clinic with dystocia. Anamnesis, signalment, physical examination, ultrasonography, radiography and subsequent intervention data were also collected. Differences in stillbirth rates between the treatment groups were evaluated using the χ2 test. The mean litter size, mean duration of labour and number of stillbirths were calculated in each case. In addition, to obtain information on further breeding of dystocia patients, 51 queen owners were contacted by telephone. Results Medical treatment was successful in 17% of patients, and 83% underwent surgical treatment for dystocia. Ovariohysterectomy (59%) was the most common surgical method, followed by conservative caesarean section (35%). En bloc resection was performed in 6% of patients. A total of four (2.4%) queens died. Of 542 kittens from 153 deliveries, 210 (39%) were stillborn. Singleton pregnancies were associated with a high risk of difficult labour. Similarly, prolonged duration of labour increased the stillbirth rate. The fertility status of queens after caesarean section was assessed by interviewing 51 owners, 27 (53%) of whom provided information. Of these, 12 were mated again and nine successfully (they became pregnant with successful natural births in five). Conclusions and relevance Similar to previous studies, our data showed that medical management led to success in only a minority of cases. In addition, mortality data for emergency births under modern standardised treatment conditions were provided. Singleton pregnancy is a suspected risk factor for dystocia. Pregnancy after caesarean section is possible with natural unassisted birth.
Use of long peripheral catheters in the infusion therapy of lung cancer patients
Authors: Liu Miao , Fang Tingting , Tao Shan , Zheng Li , Liu Yuying 
Published: February 2025

Objective: To investigate the applicability, safety, and efficacy of long peripheral catheters in the infusion therapy of lung cancer patients. Methods: A retrospective analysis was conducted to examine the baseline data, catheter placement procedures, associated complications, as well as the costs of catheter placement and maintenance among patients who underwent long peripheral catheter insertion in our lung oncology unit from June to December 2023. Results: The average catheterization time was approximately 20 min, achieving a success rate of 71.15% for a single puncture. The catheters remained in place for a duration ranging from 2 to 20 days, with a mean of 10.04 ± 4.61 days. During this period, there were three instances of venous thrombosis, eight cases of fluid leakage from the puncture site, four occurrences of occlusion, three cases of pain, and six instances of swelling at the puncture site. Notably, no cases of catheter-associated bloodstream infection, catheter fracture, or difficulty in catheter removal were reported. Complications in most patients appeared 7 days after insertion of the catheter, with only two patients experiencing complications within the initial 7-day period. The cost of catheter placement and maintenance varied between 654 and 742 RMB. Conclusion: The selection of an intravenous infusion route necessitates careful consideration, taking into account the patient’s preferences. If the patient receives a short-term infusion therapy, the infused drug is not vesicant, and the patient actively refuses to have a central venous catheter inserted, a long peripheral catheter may be a viable alternative to meet the needs of routine treatment of patients with lung cancer.
The association between national dialysis catheter use and kidney transplantation activity
Authors: Hofmann Amun G 
Published: February 2025

Background: This study investigates the relationship between national catheter use among hemodialysis (HD) patients and kidney transplantation (KTX) activity, exploring the hypothesis that higher KTX activity may be associated with increased catheter usage. The rationale is based on the idea that shorter waiting times for transplants in high-activity countries could make central venous catheters (CVCs) more favorable as a temporary bridge to transplantation compared to arteriovenous fistulas or grafts which require longer maturation times. Methods: Nine national dialysis and transplant registries (Argentina, Australia, Austria, New Zealand, Portugal, Scotland, Sweden, USA, Turkey) were included in this analysis. The included descriptive analysis of baseline information from included countries, followed by crude association analyses using correlation and regression analyses to explore the relationship between CVC usage and kidney transplants per million inhabitants, considering relevant confounders. Adjusted analyses were performed to account for these confounders, providing a more nuanced understanding of the relationship. Results: Data from nine different national registries was analyzed. CVC use and KTX activity had a weak to moderate positive correlation ( r = 0.23, 95% CI: 0.07, 0.39). In all included countries CVC use increased over time. Adjusting for temporal patterns, country-specific factors, and the proportion of female HD patients, there was still strong evidence for a moderate increase of CVCs among prevalent HD patients with increasing KTX activity. Conclusion: Higher national KTX activity is associated with a moderate increase in CVCs among prevalent HD patients.
A Cohort Study on Dual Predictive Markers of Immune Combination Therapy for Advanced Non-Small Cell Lung Cancer
Authors: Zheng Maike , Hu Mingming , Liu Yanxia , Li Xiaomi , Wang Guirong , Zhang Tongmei , Zhao Yan 
Published: February 2025

Background: Immune checkpoint inhibitors (ICIs) hold a great promise in treatment of non-small cell lung cancer (NSCLC), while only a portion of patients benefited from the treatment, and others could not achieve optimal therapeutic effects from initial immunotherapy, even for those patients with PD-L1 (Programed cell death ligand 1) tested positive. However, the clinical markers for the selection of patients who will benefit from ICIs combination treatment beforehand are largely unknown. Objectives: The purpose of this study was to explore the non-invasive biomarkers that can predict the efficacy of immune combination therapy in advanced/metastatic NSCLC patients. Design: This study employed a retrospective cohort design to analyze dual predictive biomarkers in advanced non-small cell lung cancer (NSCLC) patients with immune combination therapy. Method: An analysis was conducted on baseline information of 144 patients with advanced/metastatic NSCLC who received ICIs treatment from the November of 2018 to the January of 2023 in Beijing Chest Hospital. We established a scoring group chart to make quantitative prediction for overall survival (OS) and progression-free survival (PFS) based on 4 variables, and set up the nomogram model as well as Decision curve analysis (DCA) to assess clinical benefits of ICIs combination in treatment of patients with advanced/metastatic NSCLC. Results: We found that serum globulin (GLB) >26.6 (g/L) (HR = 1.865, P = .002), absolute neutrophil counts (ANC) (109/L) > 5 (HR = 2.146, P < .001), and bone metastasis (HR = 2.148, P < .001) were independent factors affecting the PFS of NSCLC patients. GLB > 26.6 (g/L) (HR = 1.741, P = .018), ANC (109/L) >5 (HR = 1.807, P = .008), bone metastasis (HR = 1.651, P = .002), and PD-L1 Negative (HR = 2.432, P = .032) were independent factors affecting the OS of NSCLC patients. Same variables and cut-off value have good predictive efficacy in both PFS and OS. Conclusion: In patients with advanced/metastatic NSCLC receiving ICIs combination treatment, the GLB, ANC, bone metastasis, and PD-L1 may serve as useful predictive markers for the prognosis of NSCLC patients with ICIs combination treatment.
Aerobic capacity moderates the association between cervical cord atrophy and clinical disability in mildly disabled multiple sclerosis patients
Authors: Albergoni Matteo , Preziosa Paolo , Meani Alessandro , Dallari Chiara , Valsasina Paola , Rocca Maria A , Filippi Massimo 
Published: February 2025

Background: Spinal cord volume loss is associated with clinical disability in multiple sclerosis (MS). Aerobic capacity may mitigate the impact of central nervous system (CNS) damage accumulation, exerting beneficial effects on MS-related disability. Objectives: We investigated whether aerobic capacity could moderate the association between spinal cord atrophy and clinical disability in MS. Methods: In this cross-sectional analysis, expanded disability status scale (EDSS), peak of oxygen consumption (VO2peak), brain volumetric measures, and the normalized mean upper cervical cord area (nMUCCA) were collected from 51 MS patients and 33 healthy controls (HCs). Low aerobic capacity was defined as having a VO2peak z-score less than –1.64 standard deviations. In MS patients, we explored whether the association between nMUCCA and EDSS is moderated by the level of aerobic capacity. Results: The relationship between nMUCCA and EDSS was moderated by aerobic capacity, with a significant nMUCCA × aerobic capacity interaction (β = −0.099, 95% bootstrapped confidence interval [CI] = [−0.172; −0.014], p = 0.012). Lower nMUCCA was significantly associated with higher EDSS score in MS patients with low aerobic capacity (β = −0.073, p < 0.001), but not in those with high aerobic capacity (β = 0.026, p = 0.417). Conclusions: In MS patients with mild disability, higher aerobic capacity can potentially mitigate the negative impact of spinal cord damage on clinical disability.
‘Like it’s making my heart run’: A strengths-based understanding of the play of autistic children
Authors: O’Keeffe Christina , McNally Sinead 
Published: February 2025

Play is a central feature of childhood and a fundamental right of all children. Currently, our understanding of autistic play is based on a deficit perspective, most often framed in comparison to neurotypical ‘norms’ and assumptions where the views of the players themselves have been overlooked. In moving towards a strengths-based neuroaffirmative understanding of autistic play, this study consulted with 19 autistic children (aged 5 to 13 years) using a series of semi-structured interviews and a range of creative and participatory methods. Reflexive thematic analysis generated three themes where children conceptualised: (1) enjoyment and pleasure as central to the definition of play, (2) social connections as fundamental to play and (3) play as engagement with meaningful materials and activities. Children’s autonomy and agency in play was important to all themes. These findings challenge long-standing deficit-oriented assumptions that have persisted throughout the literature for decades and have implications for future programmes of research, theory and practice, in particular on the importance of providing and facilitating authentic play experiences for autistic children in education and care contexts. Lay abstract Autistic play is generally described from a deficit perspective where the players themselves have been overlooked. It is important to consult with autistic children themselves about their understanding of play. We asked autistic children about their views on play using many different creative ways that were chosen by the children themselves. We analysed findings using reflexive thematic analysis. Autistic children in this research described play as involving feelings and emotions of pleasure and joy, autonomy and agency, playing by themselves and with others and engagement with materials and activities as meaningful. It is very important that we ask the players themselves what they think about play rather than relying on deficit framed, non-autistic definitions of autistic play. In this article, we will discuss how these findings will help develop future research, theory and practice in respecting children’s right to authentic play experiences.
Local color: Perceived racial demographics of more and less rural locations
Authors: Sargent Michael J. , Tieken Mara Casey 
Published: February 2025

In previous work, respondents overestimated the size of the US Black population, while underestimating the White population. In the present study, we examined perceptions of the racial composition of more specific locations within the US, comparing relatively rural and urban locations to one another. We expected that observers would see more rural places as having smaller Black populations, and larger White populations, compared to less rural places, but these perceived differences would exist independent of actual variation in racial makeup. In three samples, US residents judged 70 locations, estimating their racial demographics, rurality/urbanness, and desirability. Study 1 ( N = 241) tested an all-White sample; Study 2 tested a White subsample ( n = 246) and a Black subsample ( n = 263).As expected, more rural locations were judged as having larger White populations and smaller Black populations than less rural locations, beyond any actual differences in racial composition. These results support the conclusion that the mental images that Black and White respondents have of rural and urban America are characterized by stereotypes of their populations. Public Significance Statement Academic and public scholarship has assumed that the meaning of the idea of “rural” is racialized, such that places judged as rural are thought of as White, and places judged as urban are thought of as Black, beyond any actual racial differences among locations. The present data confirm the operation of such biases, demonstrating them among both Black and White observers. The data also speak to how observers estimate the size of Black and White populations in specific locations, supporting the following conclusion: people’s judgments of the racial composition of the residents of places are a product of multiple, not entirely consistent, processes.
Effect of time, temperature and chemical concentration of peracetic acid treatment on enhancement of crystallinity of jute fibers
Authors: Islam Md. Monirul , Chowdhury Mohammad Asaduzzaman , Talukder Anik , Hossain Nayem , Rana Md. Masud , Patwary Md. Ahadul Islam , Khan Ruhul Amin 
Published: February 2025

Jute is a natural fiber that decomposes organically and is widely used in textiles, composites, and many industrial applications. The cellulose’s crystallinity influences jute fibers’ durability, moisture resistance, and mechanical qualities. This study examines the impact of time, temperature, and peracetic acid (PAA) concentration on the crystallinity of cellulose jute fibers. Chemical concentration was varied with time and temperature variation to improve the crystallinity of jute fibers. After the experiment, the crystallinity of jute fibers improved altering chemical structure brought about by PAA’s removal of noncellulosic components from jute fibers. X-ray diffraction (XRD) analysis has been performed to find the crystallinity improvement in the fibers. After the chemical treatment which was performed at 2 M for 120 min at 50-60°C temperature, the maximum crystallinity was 75.34%. The findings suggest that longer treatment times and higher temperatures increase crystallinity because the PAA can easily reach the cellulose microfibrils. In addition, it was observed that the enhancement of crystallinity was significantly influenced by the optimal concentration of PAA, with an optimal concentration being identified.
Combined Mitral and Aortic Valve Surgery Through a Right Minithoracotomy: A Single-Center Experience
Authors: Fiorentino Mariafrancesca , Mikus Elisa , Tripodi Alberto , Sangiorgi Diego , Calvi Simone , Tenti Elena , Costantino Antonino , Savini Carlo 
Published: February 2025

Objective: Minimally invasive combined mitral and aortic valve surgery is still uncommon. We report our experience performing multiple valve procedures through a right-sided minithoracotomy. Methods: We present an observational case series with a retrospective analysis of 38 patients who underwent double valve surgery through right anterior thoracotomy from November 2013 to November 2023. Results: The median age of our population was 72 years, and 61% were female patients. The median EuroSCORE II was 2.27. Three patients (7.9%) had redo operations. The median cardiopulmonary bypass (CPB) and cross-clamp times were 98 and 85 min, respectively. No conversion to full sternotomy was necessary. In-hospital mortality was 2.6% (1 patient); the patient died of septic shock and consequent multiorgan failure. Of the patients, 53% required transfusions with packed blood cells. Postoperative atrial fibrillation was observed in 12 patients (32%), and 2 patients (5.2%) required pacemaker implantation due to third-degree atrioventricular block. Also, 1 stroke (2.6%) and 1 rethoracotomy for bleeding were observed. The median ventilation time was 10 h. The median intensive care unit and postoperative length of stay were 2 days and 7.5 days, respectively. Survival at 1, 3, 5, and 10 years was 93.8%, 86.3%, 86.3%, and 77.2%, respectively, with a median follow-up time of 6.5 years. Freedom from reintervention at 1, 3, 5, and 10 years was 96.8%, 89.5%, 85.0%, and 69.5%, respectively, with a median follow-up time of 5.7 years. Conclusions: In our experience, a minimally invasive approach for combined aortic and mitral valve surgery is safe and feasible, with acceptable CPB and cross-clamp times and good outcomes. Therefore, it can be an attractive option for patients with double valve diseases.
Nerve grafting or nerve transfer for suprascapular nerve reconstruction in neonatal C5C6 ± C7 brachial plexus palsies
Authors: Heitz Arthemon , Commeureuc Jeanne , Bodin Jean-Francois , Druel Thibault , Mathieu Laurent , Walch Arnaud 
Published: February 2025

This retrospective study aimed to compare two methods of reconstruction of the suprascapular nerve in neonatal brachial plexus palsy. Patients who underwent suprascapular nerve reconstruction for neonatal C5–C6 (±C7) brachial plexus palsy were included if they had at least 3 years follow-up. The results obtained after nerve surgery alone and at the end of the follow-up (after shoulder release surgery) were analysed. The primary outcome was the range of external rotation with the arm at the side. Thirty-three patients were included (19 nerve transfers, 14 nerve grafting). At last follow-up (mean 10.5 years), there was no significant difference in terms of active external rotation, range of active movement or Active Movement Scale scores for the shoulder. Active external rotation was obtained in 23 of 33 cases, 21 by nerve repair alone and two after additional shoulder release. In the present series, nerve transfer and nerve grafting provided similar results for the suprascapular nerve. Level of evidence: III
Adjuvant treatment after neoadjuvant chemoradiotherapy and surgery in patients with esophageal squamous cell carcinoma: a real-world study
Authors: Geng Yuxin , Zhao Junfeng , Li Ying , Li Yintao 
Published: February 2025

Background: Neoadjuvant chemoradiotherapy (NCRT) combined with surgery is the standard treatment option for patients with locally advanced esophageal squamous cell carcinoma (ESCC). However, whether adjuvant chemotherapy (AC) administered postoperatively has a survival benefit remains inconclusive. Objectives: To investigate whether AC is necessary after NCRT and esophagectomy and determine which patients might benefit from it. Design: A retrospective study. Methods: This retrospective study examined patients with ESCC treated with NCRT followed by radical esophagectomy at three hospitals between March 2016 and December 2022. Patients were assigned into the adjuvant and non-adjuvant therapy groups based on whether they received postoperative AC, allowing the comparison of disease-free survival (DFS) and overall survival (OS) between the two groups. In addition, based on whether postoperative pathology indicated pathological complete response (pCR), patients were classified into the pCR and non-pCR populations, with DFS and OS separately analyzed for each subgroup. Results: Overall, 218 eligible patients were enrolled. No significant advantage was found in DFS ( p = 0.540) and OS ( p = 0.058) between the adjuvant and non-adjuvant therapy groups. In the non-pCR population, the adjuvant therapy groups had a significant advantage in DFS ( p = 0.046) and OS ( p = 0.011) compared to the non-adjuvant therapy group. However, in the pCR population, no significant advantage was found in DFS ( p = 0.490) and OS ( p = 0.110) analyses between the adjuvant and non-adjuvant therapy groups. Conclusion: In the real world, patients with ESCC who underwent NCRT combined with radical esophagectomy and whose postoperative pathology was pCR did not benefit from AC. However, AC significantly improved DFS and OS in patients whose postoperative pathology did not reach pCR.
Clinical impact of hypomagnesemia induced by necitumumab plus cisplatin and gemcitabine treatment in patients with advanced lung squamous cell carcinoma: a subanalysis of the NINJA study
Authors: Tanzawa Shigeru , Yoshioka Hiroshige , Misumi Toshihiro , Miyauchi Eisaku , Ninomiya Kiichiro , Murata Yasunori , Takeshita Masafumi , Kinoshita Fumihiko , Fujishita Takatoshi , Sugawara Shunichi , Kawashima Yosuke , Hashimoto Kazuki , Mori Masahide , Miyanaga Akihiko , Hayashi Anna , Tanaka Hisashi , Honda Ryoichi , Nojiri Masafumi , Sato Yuki , Hata Akito , Ishikawa Nobuhisa , Kozuki Toshiyuki , Kawamura Takahisa , Saito Go , Yamaguchi Teppei , Asada Kazuhiro , Tetsumoto Satoshi , Tanaka Hiroshi , Watanabe Satoshi , Umeda Yukihiro , Yamaguchi Kakuhiro , Nishii Kazuya , Tsuruno Kosuke , Misumi Yuki , Kuraishi Hiroshi , Yoshihara Ken , Nakao Akira , Kubo Akihito , Yokoyama Toshihiko , Watanabe Kana , Seki Nobuhiko 
Published: February 2025

Background: The clinical impact of hypomagnesemia induced by necitumumab plus gemcitabine and cisplatin (GCN) as a second-line or later therapy is unclear. Objective: We aimed to evaluate the clinical characteristics and survival impact of hypomagnesemia induced by this therapy. Design: This was a sub-analysis of the retrospective multicenter NINJA study. Methods: Among the 93 patients enrolled in the NINJA study, this subanalysis included 75 patients with baseline serum magnesium concentrations. Results: The incidence of grade ⩾2 hypomagnesemia was 18.0% in the patients with normal baseline serum magnesium concentrations and 42.8% in those with low concentrations ( p = 0.073). The discontinuation rates of GCN treatment owing to hypomagnesemia in each group were 0% and 7.1%, respectively ( p = 0.187). The number of necitumumab doses and severity of hypomagnesemia were positively correlated ( r = 0.389, p < 0.001). Patients who developed hypomagnesemia in fewer than 21 days after the first dose of GCN ( n = 12) had significantly poorer progression-free survival (PFS) than those without the condition ( n = 63; median: 4.1 vs 4.4 months, p = 0.048). A similar trend was observed for OS (median: 9.7 vs 15.7 months, p = 0.062). These results were maintained after multivariate analyses (PFS: hazard ratio (HR) 2.46, p = 0.014; OS: HR 2.78, p = 0.021). Conclusion: GCN as a second-line or later therapy may be tolerable regardless of the patient’s baseline serum magnesium concentration. On the other hand, early serum magnesium reduction with this therapy is associated with a poor prognosis. However, caution should be needed because our results lacked sufficient information for confounding variables other than those analyzed here that may influence the correlation between hypomagnesemia and survival.