bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting bentonite swelling pressure: optimized XGBoost versus neural networks
Authors: Utkarsh  , Jain Pradeep Kumar 
Published: July 2024

AbstractThe swelling pressure of bentonite and bentonite mixtures is critical in designing barrier systems for deep geological radioactive waste repositories. Accurately predicting the maximum swelling pressure is essential for ensuring these systems' long-term stability and sealing characteristics. In this study, we developed a constrained machine learning model based on the extreme gradient boosting (XGBoost) algorithm tuned with grey wolf optimization (GWO) to determine the maximum swelling pressure of bentonite and bentonite mixtures. A dataset containing 305 experimental data points was compiled, including relevant soil properties such as montmorillonite content, liquid limit, plastic limit, plasticity index, initial water content, and soil dry density. The GWO-XGBoost model, incorporating a penalty term in the loss function, achieved an R2 value of 0.9832 and an RMSE of 0.5248 MPa in the testing phase, outperforming feed-forward and cascade-forward neural network models. The feature importance analysis revealed that dry density and montmorillonite content were the most influential factors in predicting maximum swelling pressure. While the developed model demonstrates high accuracy and reliability, it may have limitations in capturing extreme values due to the complex nature of bentonite swelling behavior. The proposed approach provides a valuable tool for predicting the maximum swelling pressure of bentonite-based materials under various conditions, supporting the design and analysis of effective barrier systems in geotechnical engineering applications.
Investigating adhesion of primary human gingival fibroblasts and osteoblasts to orthodontic mini-implants by scanning electron microscopy
Authors: Reimers Sarah Nadine Mirja , Es-Souni Martha , Şen Sinan 
Published: July 2024

AbstractMiniscrews offer controlled anchorage and thus optimize tooth movement in orthodontic treatment. Nevertheless, failures such as soft tissue problems, instability due to loosening, partial osseointegration, or even device fracture can occur. While clinical technique can play a role in some of these problems, the manufacturer’s design and material choice influence how the implant interacts with the surrounding tissue. In some cases, the design and material may trigger unwanted bone and soft tissue responses. This in vitro study investigates how the implant surface affects cell adhesion and growth of human primary fibroblasts and osteoblasts on commercially available orthodontic TiAl6V4 miniscrews from three producers: tomas-pin SD N 08 (Dentaurum), OrthoEasy Pin (Forestadent), and Dual Top G2 (Promedia, Jeil Medical). Cell–implant interaction at the top, neck, and drilling part of the screws was assessed qualitatively by scanning electron microscopy. While both cell types adhered to and grew on all products, subtle differences in cell shape and spreading were detected, depending on the microstructure of the implant surface. This indicates that cell adhesion to implant surfaces can be controlled by manipulating the machining conditions.
Leadership, spirituality and empowerment: examining the experiences of women of color in fortune 500 companies
Authors: Sengupta Ayesha , Follmer Kayla , Louis Debra 
Published: July 2024

PurposeThis paper investigates the meaning of spirituality and empowerment from the perspective of women of color (WOC) in Fortune 500 companies how it impacts their leadership.Design/methodology/approachDetailed data were collected through in depth semi-structured interviews documenting their experience as lived in the context of their daily work environments. Twelve WOC in leadership positions were interviewed, and transcripts analyzed using thematic analysis. Their narratives provide insight into the experiences of discrimination and bias and the stress and disenfranchisement that result from these experiences.FindingsAnalysis shows that for these women, spirituality was more than a philosophical orientation but comprised a core facet of their identity, empowering them to cope with adversity and uplift others through a leadership style defined by compassion, trust, strong interpersonal relationships and purpose.Practical implicationsImplications for creating more compassionate and inclusive environments that draw on principles of empowerment and spiritual leadership are provided.Originality/valueThis study contributes uniquely to the literature by exploring the perspectives of understudied women leaders who identify as African American, South-Asian and Latina on spirituality and empowerment and their impact on their leadership.
How mineral resources rent collaborate with consumer price index, environmental policies, and economic performance in Türkiye and India: Evidence from artificial neural networks and machine learning
Authors: Nazir Aqsa , Iqbal Munawar , Mehmood Usman , Haq Zia Ul , Rana Asim Daud , Alofaysan Hind 
Published: July 2024

AbstractTaking focus on the possible effects on welfare and environmental issues in Türkiye and India, this study explores the relationship between the leasing of mineral resources (MRs), economic performance, use of renewable energy, and environmental policies. The study estimates changes in MRs throughout economic expansion using artificial intelligence (artificial neural network [ANN]) and supervised machine learning (SML). It focuses on important variables like index of stringency of environmental policies and the consumer price index, the conclusions of the ANN, ensemble method, and ML studies show how sensitive quarterly changes in the rent on MRs are to changes in the consumer price index, economic performance, and the use of renewable energy. Evaluation criteria such as root mean square error (RMSE), mean absolute error (MAE), mean square error (MSE), mean absolute percentage error (MAPE), and coefficient of determination highlight how much better ML models predict outcomes than ANN trials. In particular, the ML findings show an outstanding R2 of 0.99, an MAE of 0.6625, an MSE of 0.8324, a MAPE of 35.3677, and an RMSE of 0.9123 for India. Türkiye's machine learning results, on the other hand, display an MAE of 0.0164, an MSE of 0.0007, MAPE of 66.1594, RMSE of 0.0279, and a strong R2 of 0.98. For ANN, the error histogram is plotted to assess the model. The extremely low value of 0.0090 and 0.010, respectively, for Türkiye and India on the error histogram reflects the exceptional prediction quality. Türkiye and India have abundant MRs; however, they must be managed correctly for long‐term sustainability. Future researchers may verify this work using time series or panel data from other disciplines. This study examines factors affecting sustainable economic growth, including MR use, environmental policies, and eco‐friendly innovations. Other indicators, such as energy efficiency, carbon dioxide emissions, renewable energy consumption, and global value chain participation, may provide a different perspective. This study's conclusions should be verified by more research employing other geographic locations and others machine learning methods, as well as to illustrate how sustainable development is influenced by other variables.
Targeting Syntaxin 1A via RNA interference inhibits feeding and midgut development in Locusta migratoria
Authors: Liu Xiaojian , Gao Ya , Li Yao , Zhang Jianzhen 
Published: July 2024

AbstractSyntaxin 1A (Syx1A) has diverse and indispensable functions in animals. Previous studies have mainly focused on the roles of Syx1A in Drosophila, and so how Syx1A operates during the development of other insects remains poorly understood. This study investigated whether disrupting LmSyx1A using RNA interference (RNAi) affects the growth and development of Locusta migratoria. LmSyx1A was expressed in all tissues tested, with the highest expression observed in the fat body. After 5th‐instar nymphs were injected with double‐stranded LmSyx1A (dsLmSyx1A), none of the nymphs were able to molt normally and all eventually died. The silencing of LmSyx1A resulted in the cessation of feeding, body weight loss, and atrophy of the midgut and gastric cecum in locusts. Hematoxylin and eosin (H&E) staining showed that the columnar cells in the midgut were severely damaged, with microvilli defects visible in dsLmSyx1A‐injected nymphs. Secretory vesicles were observed with transmission electron microscopy (TEM). In addition, reverse transcription quantitative polymerase chain reaction (RT‐qPCR) further indicates that silencing LmSyx1A repressed the expression of genes involved in the insulin/mammalian target of rapamycin (mTOR)‐associated nutritional pathway. Taken together, these results suggest that LmSyx1A significantly affects the midgut cell layer of locust nymphs, which was partially associated with the downregulation of the insulin/mTOR‐associated nutritional pathway. Thus, we argue that LmSyx1A is a suitable target for developing dsRNA‐based biological pesticides for managing L. migratoria.
Why couple infertility is historically a female‐driven problem?
Authors: Vignozzi Linda , Cipriani Sarah , Lippi Donatella 
Published: July 2024

AbstractBackgroundThe history of studies in the field of infertility represents a chapter of great interest in gender issues.ObjectivesThis paper aims to delve deep into the historical roots of the aspect of gender inequality related to couple infertility, with a journey back in time, from classical antiquity to the contemporary age, reporting junctions and metaphors linked to particular historical moments as well as to cultural and religious constructs.MethodsThis is a narrative review based on an extensive literature search of publications regarding the role of women in couple infertility over the centuries.ResultsRarely in the ancient world, male infertility was taken into consideration, and the sources deal with it mainly indirectly. This attitude of “blaming” the woman for the lack of children had, in fact, strong social implications, which only the scientific research of recent years has managed to bring back into the context of a more egalitarian approach.ConclusionsIn the “journey” narrated in this article, the reader starts from the responsibility of couple infertility attributed exclusively to women in some ancient societies, whose central role was determined by their ability to procreate, going up to the medicalization of infertility in the contemporary age, which contributed to sharing with men this participation in the impossibility of having children.
Entrepreneurial leadership and innovation in the public sector: The role of causal‐ and effectual‐logic processes
Authors: Kousina Elisavet , Deligianni Ioanna , Voudouris Irini 
Published: July 2024

AbstractEntrepreneurial leadership in the public sector has attracted the interest of both scholars and policymakers, as it is seen as a key determinant of innovation. This study adopts a contingency view of leadership and examines the entrepreneurial leadership–innovation relationship while also considering the moderating effects of the causal‐ and effectual‐logic processes employed. Based on multisource data across 105 municipal departments in Greece, the findings suggest that entrepreneurial leadership exerts a positive effect on exploratory innovation; this effect is further reinforced by formalization. In contrast, entrepreneurial leadership's influence on exploitative innovation depends on collaboration and conditions of working with limited means, in such a way that the impact is positive only at high levels of these effectual‐logic processes; at low levels, it is negative. Practical implications are discussed for public organizations seeking to translate entrepreneurial leadership into innovation.
Supplemental Material: Post-glacial stratigraphy and late Holocene record of great Cascadia earthquakes in Ozette Lake, Washington, USA
Authors: Brothers Daniel S. , al. et 
Published: July 2024

<p>Provides additional detailed descriptions of the age modeling approaches, results, and potential trade-oﬀs, as well as several tables and ﬁgures in support of the main text. </p>
Clinical characteristics, predisposing factors, and management of moraxella keratitis in a tertiary eye hospital
Authors: Soleimani Mohammad , Najafabadi Sadra Jalali , Razavi Alireza , Tabatabaei Seyed Ali , Mirmoosavi Saeed , Asadigandomani Hassan 
Published: July 2024

Abstract
Purpose
The Moraxella species is a very uncommon pathogen that leads to microbial keratitis (MK). This study aimed to evaluate the clinical features, predisposing factors, and outcomes of Moraxella keratitis in patients of a tertiary eye hospital.

Methods
This retrospective study was conducted from 2015 to 2022, on patients who were admitted with the diagnosis of Moraxella keratitis confirmed by positive culture in a referral eye hospital. Demographics, predisposing factors, best-corrected visual acuity (BCVA), and prognosis were assessed.

Results
A total of 106 individuals diagnosed with Moraxella keratitis, were analyzed. The mean age was 54.42 ± 19.43 years. The mean baseline BCVA of the patients was 2.28 ± 0.6 LogMAR, while this amount reached 1.49 ± 0.81 in the 6-month follow-up (P-value = 0.02). The mean BCVA in the six-month follow-up of the patients who needed surgical interventions was significantly lower than the patients who received only medical treatment (2.15 ± 0.65 vs. 1.29 ± 0.75 LogMAR, P-value = 0.02). Patients with diabetes and those without diabetes did not substantially vary in the prevalence of corneal perforation (P-value = 0.515). Three predisposing factors including corneal perforation (odds ratio = 19.27, P-value = 0.001), hypertension (HTN) (odds ratio = 3.62, P-value = 0.03), and older age (odds ratio = 1.03, P-value = 0.008) were significantly associated with more need for surgical interventions.

Conclusion
In this cohort, poor prognosis necessitating surgical interventions in Moraxella keratitis was found to be associated with corneal perforation, HTN, and older age.
Multioviz: an interactive platform for in silico perturbation and interrogation of gene regulatory networks
Authors: Xie Helen , Crawford Lorin , Conard Ashley Mae 
Published: July 2024

AbstractIn this paper, we aim to build a platform that will help bridge the gap between high-dimensional computation and wet-lab experimentation by allowing users to interrogate genomic signatures at multiple molecular levels and identify best next actionable steps for downstream decision making. We introduce : a publicly accessible package and web application platform to easily perform in silico hypothesis testing of generated gene regulatory networks. We demonstrate the utility of by conducting an end-to-end analysis in a statistical genetics application focused on measuring the effect of in silico perturbations of complex trait architecture. By using a real dataset from the Wellcome Trust Centre for Human Genetics, we both recapitulate previous findings and propose hypotheses about the genes involved in the percentage of immune CD8+ cells found in heterogeneous stocks of mice. Source code for the package is available at https://github.com/lcrawlab/multio-viz and an interactive version of the platform is available at https://multioviz.ccv.brown.edu/.
The first complete mitochondrial genome of Grossulariaceae: Molecular features, structure recombination, and genetic evolution
Authors: Lu Guilong , Wang Wenhua , Zhang Shanshan , Yang Guang , Zhang Kun , Que Youxiong , Deng Lan 
Published: July 2024

Abstract
Background
Mitochondria play crucial roles in the growth, development, and adaptation of plants. Blackcurrant (Ribes nigrum L.) stands out as a significant berry species due to its rich nutritional profile, medicinal properties, and health benefits. Despite its importance, the mitochondrial genome of blackcurrant remains unassembled.

Results
This study presents the first assembly of the mitochondrial genome of R. nigrum in the Grossulariaceae family. The genome spans 450,227 base pairs (bp) and encompasses 39 protein-coding genes (PCGs), 19 transfer RNAs (tRNAs), and three ribosomal RNAs (rRNAs). Protein-coding regions constitute 8.88% of the entire genome. Additionally, we identified 180 simple sequence repeats, 12 tandem repeats, and 432 pairs of dispersed repeats. Notably, the dispersed sequence R1 (cotig3, 1,129 bp) mediated genome recombination, resulting in the formation of two major conformations, namely master and double circles. Furthermore, we identified 731 C-to-U RNA editing sites within the PCGs. Among these, cox1-2, nad1-2, and nad4L-2 were associated with the creation of start codons, whereas atp6-718 and rps10-391 were linked to termination codons. We also detected fourteen plastome fragments within the mitogenome, constituting 1.11% of the total length. Phylogenetic analysis suggests that R. nigrum might have undergone multiple genomic reorganization and/or gene transfer events, resulting in the loss of two PCGs (rps2 and rps11) during its evolutionary history.

Conclusions
This investigation unveils the molecular characteristics of the R. nigrum mitogenome, shedding light on its evolutionary trajectory and phylogenetic implications. Furthermore, it serves as a valuable reference for evolutionary research and germplasm identification within the genus.
A delayed response in phytohormone signaling and production contributes to pine susceptibility to Fusarium circinatum
Authors: Hernandez-Escribano Laura , Morales Clemente M. Teresa , Fariña-Flores David , Raposo Rosa 
Published: July 2024

Abstract
Background
Fusarium circinatum is the causal agent of pine pitch canker disease, which affects Pinus species worldwide, causing significant economic and ecological losses. In Spain, two Pinus species are most affected by the pathogen; Pinus radiata is highly susceptible, while Pinus pinaster has shown moderate resistance. In F. circinatum-Pinus interactions, phytohormones are known to play a crucial role in plant defense. By comparing species with different degrees of susceptibility, we aimed to elucidate the fundamental mechanisms underlying resistance to the pathogen. For this purpose, we used an integrative approach by combining gene expression and metabolomic phytohormone analyses at 5 and 10 days post inoculation.

Results
Gene expression and metabolite phytohormone contents suggested that the moderate resistance of P. pinaster to F. circinatum is determined by the induction of phytohormone signaling and hormone rearrangement beginning at 5 dpi, when symptoms are still not visible. Jasmonic acid was the hormone that showed the greatest increase by 5 dpi, together with the active gibberellic acid 4 and the cytokinin dehydrozeatin; there was also an increase in abscisic acid and salicylic acid by 10 dpi. In contrast, P. radiata hormonal changes were delayed until 10 dpi, when symptoms were already visible; however, this increase was not as high as that in P. pinaster. Indeed, in P. radiata, no differences in jasmonic acid or salicylic acid production were found. Gene expression analysis supported the hormonal data, since the activation of genes related to phytohormone synthesis was observed earlier in P. pinaster than in the susceptible P. radiata.

Conclusions
We determine that the moderate resistance of P. pinaster to F. circinatum is in part a result of early and strong activation of plant phytohormone-based defense responses before symptoms become visible. We suggest that jasmonic acid signaling and production are strongly associated with F. circinatum resistance. In contrast, P. radiata susceptibility was attributed to a delayed response to the fungus at the moment when symptoms were visible. Our results contribute to a better understanding of the phytohormone-based defense mechanism involved in the Pinus-F. circinatum interactions and provide insight into the development of new strategies for disease mitigation.
The photoreactivation of 6 − 4 photoproducts in chloroplast and nuclear DNA depends on the amount of the Arabidopsis UV repair defective 3 protein
Authors: Zgłobicki Piotr , Hermanowicz Paweł , Kłodawska Kinga , Bażant Aneta , Łabuz Justyna , Grzyb Joanna , Dutka Małgorzata , Kowalska Ewa , Jawor Joanna , Leja Katarzyna , Banaś Agnieszka Katarzyna 
Published: July 2024

Abstract
Background
6 − 4 photoproducts are the second most common UV-induced DNA lesions after cyclobutane pyrimidine dimers. In plants, they are mainly repaired by photolyases in a process called photoreactivation. While pyrimidine dimers can be deleterious, leading to mutagenesis or even cell death, 6 − 4 photoproducts can activate specific signaling pathways. Therefore, their removal is particularly important, especially for plants exposed to high UV intensities due to their sessile nature. Although photoreactivation in nuclear DNA is well-known, its role in plant organelles remains unclear. In this paper we analyzed the activity and localization of GFP-tagged AtUVR3, the 6 − 4 photoproduct specific photolyase.

Results
Using transgenic Arabidopsis with different expression levels of AtUVR3, we confirmed a positive trend between these levels and the rate of 6 − 4 photoproduct removal under blue light. Measurements of 6 − 4 photoproduct levels in chloroplast and nuclear DNA of wild type, photolyase mutants, and transgenic plants overexpressing AtUVR3 showed that the photoreactivation is the main repair pathway responsible for the removal of these lesions in both organelles. The GFP-tagged AtUVR3 was predominantly located in nuclei with a small fraction present in chloroplasts and mitochondria of transgenic Arabidopsis thaliana and Nicotiana tabacum lines. In chloroplasts, this photolyase co-localized with the nucleoid marked by plastid envelope DNA binding protein.

Conclusions
Photolyases are mainly localized in plant nuclei, with only a small fraction present in chloroplasts and mitochondria. Despite this unbalanced distribution, photoreactivation is the primary mechanism responsible for the removal of 6 − 4 photoproducts from nuclear and chloroplast DNA in adult leaves. The amount of the AtUVR3 photolyase is the limiting factor influencing the photoreactivation rate of 6 − 4 photoproducts. The efficient photoreactivation of 6 − 4 photoproducts in 35S: AtUVR3-GFP Arabidopsis and Nicotiana tabacum is a promising starting point to evaluate whether transgenic crops overproducing this photolyase are more tolerant to high UV irradiation and how they respond to other abiotic and biotic stresses under field conditions.