bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Identification of UBE2C As a Prognostic Biomarker and Correlated with Immunosuppression and Invasiveness in Glioma
Authors: Feng Hao , Fu Anhui , Yang Rong , Qiao Fei 
Published: July 2024

Abstract

Glioma is one of the common tumors of the central nervous system, which presents difficulties in clinical diagnosis and treatment due to its characteristics of immunosuppression and cell invasion phenotypes. If the condition and prognosis of glioma can be predicted during the process of diagnosis and treatment, it will be more conducive to timely intervention or evaluation of glioma. Therefore, we still need to search for more valuable tumor markers. The differential/risk genes and enrichment analysis based on glioma samples (The Cancer Genome Atlas, TCGA). Target gene UBE2C were obtained by the expression correlation and differential expression analysis for the enrichment results. UBE2C were evaluated by clinical grading, survival prognosis and cell experiments. The correlation of UBE2C with immune invasion, immune checkpoint, network analysis and cell invasiveness of gliomas was analyzed by TCGA-glioma data and STRING, respectively. The results suggests that the high expression and risk of UBE2C in gliomas may be a factor that promotes malignant phenotype of tumor cells. The immune phenotype shows that IL6 and IL10 may be the key nodes affecting the immunosuppressive phenotype of glioma. Further, the tumor cells aggressive genes from the MMP family can be correlated with immunosuppressive phenotypes via UBE2C-IL6/IL10 axis, especially displayed by MMP2/MMP9. The UBE2C may systemically effects the malignant phenotype, immunosuppression and cell invasiveness of tumors systematically, which reflects UBE2C as a potential biomarker of glioma and therapeutic target for this tumor.
The impact of robotic surgery on the treatment of benign esophageal and gastric disease. Early experience of a specialized unit
Authors: Saliaris Konstantinos , Karikis Ioannis , Mela Eugenia , Katsila Sofia , Kitsou Eleni , Smparounis Spyridon , Linardoutsos Dimitrios , Theodorou Dimitrios , Triantafyllou Tania 
Published: July 2024

Abstract

Background: Laparoscopic surgery is a well-established approach in the surgical treatment of reflux, hiatal hernia and esophageal motility disorders such as achalasia. Robotic platforms have only recently been incorporated in surgery for esophageal motility disorders and their exact value remains to be determined. In the present study, we present the preliminary results of our early experience with a case series of benign upper gastrointestinal diseases treated using the robotic system in our department.
Methods: Data on all consecutive patients undergoing surgery for benign UGI disease during the last five years (01/2029-12/2023) was prospectively collected and retrospectively reviewed. All patients attended regular follow-up appointments. Patients with relapse or deterioration of their symptoms were referred for objective testing using high-resolution manometry and/or 24-h impedance pHmetry.
Results: Fourteen patients with achalasia underwent robotic Heller myotomy and modified Dor fundoplication, sixteen patients underwent hiatal hernia repair with fundoplication and four patients had a Nissen fundoplication for reflux esophagitis. The median postoperative Eckardt score of the patients treated for achalasia was 2 and a median GERD score of 1 was recorded for patients treated for reflux. Two patients with achalasia were evaluated with manometry due to temporary symptom relapse. The manometric findings were unremarkable.
Conclusion: The incorporation of the robotic approach in the surgical treatment of benign UGI diseases is safe and feasible with excellent perioperative and postoperative functional results. Further experience and investigation will allow for reliable comparison to the laparoscopic approach.
Hybrid Gate-Based and Annealing Quantum Computing for Large-Size Ising Problems
Authors: Liu Chen-Yu , Goan Hsi-Sheng 
Published: July 2024

Abstract

One of the major problems of quantum computing applications is that the required number of qubits to solve a practical problem is much larger than that of today's quantum hardware. In this work, we introduce the large-system sampling approximation (LSSA) algorithm to solve Ising problems with sizes up to Ngb2Ngb by an Ngb-qubit gate-based quantum computer, and problems with sizes up to Nan2Ngb by a hybrid computational architecture of an Nan-qubit quantum annealer and an Ngb-qubit gate-based quantum computer. By dividing the full-system problem into smaller subsystem problems, the LSSA algorithm then solves the subsystem problems by either gate-based quantum computers or quantum annealers, and optimizes the amplitude contributions of the solutions of the different subsystems with the full-problem Hamiltonian by the variational quantum eigensolver (VQE) on a gate-based quantum computer to determine the approximated ground-state configuration. LSSA has polynomial time complexity and can be further extended to a deeper level of approximation with computational overhead that grows linearly with the problem size. The effects of different subsystem sizes, numbers of subsystems, and full problem sizes on the performance of LSSA are investigated on both simulators and real hardware. The completely new computational concept of the hybrid gate-based and annealing quantum computing architecture opens a promising possibility to investigate large-size Ising problems and combinatorial optimization problems, making practical applications by quantum computing possible in the near future.
A special graph for the connected metric dimension of graphs
Authors: Batiha Iqbal M. , Anakira Nidal , Hashim Amal , Mohamed Basma 
Published: July 2024

Given a connected graph G=(V, E), let d(x, y) represent the separation between x and y at its vertices. If each vertex in a collection B is uniquely identified by its vector of distances to the vertices in B, then that set of vertices resolves a graph G. A metric dimension of G is represented by dim(G) and is the smallest cardinality of a resolving set of G. If the subgraph B- induced by B is a nontrivial connected subgraph of G, then a resolving set B of G is connected. The metric dimension of G is the cardinality of the minimal resolving set, while the connected metric dimension of G is the cardinality of the smallest connected resolving set. The connected metric dimension of the knots graph, whitehead link graph and jewel graph are determined in this study. Finally, we derive the explicit formulas for the triangular book graph, quadrilateral book graph and crystal planar map.
Topical Administration of Nanostructured Lipid Carriers as a Viable Approach to Reduce Inflammation: A Review
Authors: Rajak Prakash , Karmakar Arka , Sarma Santa , Bhuyan Biman 
Published: July 2024

:
This review seeks to assess the potential of nanomaterials, specifically Nano-structured
Lipid Carriers (NLCs), in mitigating challenges associated with inflammation-related
disorders, with a particular emphasis on chronic ailments like arthritis. A comprehensive literature
review spanning Web of Science, PubMed, and other scholarly repositories from 2000
to 2023 is conducted. Articles are selected based on their focus on NLCs and inflammation
management, utilizing keywords, such as "nanomaterials," "targeted drug delivery," and "arthritis."
Exclusion criteria involve non-English studies or those lacking adequate detail on
NLCs. Synthesized data provide an overview of the advantages, challenges, and prospects of
NLCs in addressing chronic inflammatory disorders. This review also examines the therapeutic
applications of nanotechnology, including targeted drug delivery and tissue engineering,
particularly focusing on the intricate biological responses in chronic inflammation, often involving
Non-steroidal Anti-inflammatory Drugs (NSAIDs). Moreover, the exploration extends
to topical delivery methods to enhance control over medication concentration, with a
review of lipid nanoparticles, such as liposomes and solid-lipid nanoparticles, highlighting
their potential in augmenting drug permeation while addressing challenges like inadequate
drug loading.

:
NLCs have emerged as promising candidates for overcoming drug delivery challenges, particularly
in arthritis treatment, with a focus on their advantages across diverse lipid compositions.
The review underscores significant strides in inflammation management through NLC
utilization, offering insights into future research directions.

:
Moreover, it contributes to ongoing advancements in nanomedicine, emphasizing the pivotal
role of NLCs in developing innovative therapeutic approaches for inflammation-related disorders,
particularly arthritis. NLCs represent a promising avenue for effective interventions,
signaling progress in nanotechnology-enabled therapeutics.
Examining the Difficulties in Identifying and Handling Cardiac Amyloidosis; Acquiring Important Knowledge and Robust Treatment Methods
Authors: Ali Ghadir Mohammed Saleh , Seme William Ale Emmanuel , Dudhat Kiran 
Published: July 2024

:
Systemic amyloidosis is a rare protein misfolding and deposition condition that causes
slow organ failure. Each of the more than 15 exclusive sorts of systemic amyloidosis, which encourage
amyloid production and tissue deposition, is introduced by a unique precursor protein.
Amyloidosis can affect various organs, including the heart, kidneys, liver, nerves, gastrointestinal
tract, lungs, muscles, skin, and soft tissues. It can either be acquired or hereditary. Insidious
and doubtful signs often cause a put-off in diagnosis. In the closing decade, noteworthy progressions
have been made in the identity, prediction, and handling of amyloidosis. Shotgun proteomics
based on mass spectrometry has revolutionized amyloid typing and enabled the identification
of novel amyloid forms. It is critical to correctly identify the precursor protein implicated in
amyloidosis because the kind of protein influences the proper treatment strategy. Cardiac amyloidosis
is a disorder characterized by the systemic accumulation of amyloid protein in the myocardium's
extracellular space, which causes a variety of symptoms. The buildup of amyloid aggregates
precipitates myocardial thickening and stiffening, culminating in diastolic dysfunction
and, in due course, heart failure. We examine every kind of systemic amyloidosis in this text to
offer practitioners beneficial equipment for diagnosing and treating those unusual diseases. This
review presents a comprehensive analysis of cardiac amyloidosis and consolidates current methods
for screening, diagnosis, evaluation, and treatment alternatives.
Pregnancy in Autoimmune Hypophysitis: Management of a Rare Condition
Authors: Costanza Flavia , Cicia Martina , Giampietro Antonella , Tartaglione Tommaso , Angelini Flavia , Zoli Angelo , Ferrazzani Sergio , De Marinis Laura , Pontecorvi Alfredo , Bianchi Antonio , Chiloiro Sabrina 
Published: July 2024

Introduction:
Hypophysitis is an inflammatory disorder of the pituitary gland. It can
manifest variously, with endocrinological and neuro-ophthalmologic symptoms and signs, due to
the compression of sellar and parasellar structures.

Case Representation:
Although hypophysitis is rare, this pituitary disease can occur during pregnancy
or in the postpartum period. In this report, we describe the case of a woman with partial hypopituitarism
secondary to autoimmune hypophysitis who, five years after the diagnosis and the
immunosuppressive treatment, had an uneventful pregnancy and successfully delivered a healthy
infant at term.

Conclusion:
We reported the clinical history of the patient and the evolution of the disease and also
reviewed the management and treatment of autoimmune hypophysitis during pregnancy.
Traveling food tourism with children industry: motivation, involvement, experience value and visit intention
Authors: Zhu Yawen , Liu Lu 
Published: July 2024

Abstract
The traveling food tourism with children industry has become a rapidly developing tourism market after the epidemic. Parents, children, and sightseeing factories have all benefited positively from their shared family travel experiences. Based on the value co-creation theory, this study analyzes literature related to traveling with children from a group perspective, selects variables and dimensions based on the characteristics of traveling with children in China, and investigate the relationships among motivation, involvement, experience value and visit intention in the context of the food tourism industry. Analysis of data from 578 respondents indicates that the proposed model fits the data well. The results indicate that the motivation of traveling with children does not have a direct positive impact on visit intention, but through tourism involvement and experience value, it can indirectly affect the visit intention of tourists with children. Empirical analysis is expected to contribute to the study on the experience theory of traveling with children. At the same time, targeted guidance and suggestions can be provided for product design, marketing strategy, and experience management in the food tourism industry.
Measurement of effectiveness spinning fiber machines using total productive maintenance method at textile manufacturing
Authors: Supriyadi Edi , Nurdewanti Rully 
Published: July 2024

PT XYZ is a textile industry manufacturing company whose main products are Polymer Chips, Pre-Oriented Yarn (POY), Draw Twister Yarn (DTY), Bi Shrankage Yarn (BSY), and Polyester Staple Fiber (PSF) which are marketed domestically and internationally. There are still high breakdown problems, which can hamper the production process and result in a decrease in production capacity. The purpose of this study was to measure the Performance Effectiveness of Fiber Spinning Machines using the Total Productive Maintenance (TPM) Method and to find the causes of the Six Big Losses that affect the Performance Effectiveness of Fiber Spinning Machines. The application of TPM in the manufacturing industry aims to extend machine life and maximize the effectiveness of machine performance. The results of measuring the Performance Effectiveness of Fiber Spinning Machines using the TPM Method obtained an Overall Equipment Effectiveness (OEE) value of 87.85% and the cause of Six Big Losses that affect the effectiveness of the performance of Fiber Spinning Machines is Equipment Failure Losses, the most dominant factor is the Human Factor, namely lack of control, lack of understanding of Standard Operational Procedure (SOP), lack of thoroughness when cleaning spinnerets.
Erosion Hazard Class Mapping in Dolago Das, South Parigi Sub-district
Authors: Rifki Lumalan Manguma  , Ida Arianingsih  , Misrah  , Hasriani  , Akhbar  
Published: July 2024

Introduction: Erosion can be caused by natural activities or human activities. Erosion events that occur naturally do not cause too many problems, but erosion events caused by humans can cause various problems of land damage or degradation and experience an accelerated rate of erosion. The Dolago watershed has an area of ±17,283.09 ha and is a priority watershed that needs attention because several natural disasters such as erosion, landslides, and floods have harmed the community when rainfall increases. Method: Based on the case above, researchers studied the erosion risk class of the Dolago watershed by combining erosion prediction methods, namely USLE and Geographic Information Systems. Erosion hazard class research was carried out in the Dolago watershed for 3 months, from September to November 2022 using the Universal Soil Loss Equation method and Geographic Information System, namely Overlay of several data (erosion determining parameters) to determine the erosion hazard class in the Dolago watershed. Results and Discussion: The results of research using the Geographic Information System and the Universal Soil Loss Equation method show that the amount of eroded soil in the Dolago watershed is 23,888.80 tons/ha/year and the erosion hazard class is divided into 5 classes, namely Class I (very light) erosion rate <15 tons/ha/year with an area of 15,111.55 ha, class II (light) erosion rate 15 - 60 tons/ha/year with an area of 175.52 ha, class III (medium) erosion rate 61 - 180 tons/ha/year with an area of 1,244.87 ha, class IV (heavy) erosion rate 180 - 480 tonnes/ha/year with an area of 491.66 ha and class V (very heavy) erosion rate >480 tonnes/ha/year with an area of 259.49 ha. Conclusion: Combining the geographic information system and the USLE method, five types of erosion hazard classes can be produced, namely class I classified as very light with an area of 15,111.55 ha percentage of 82.81%, class II classified as light with an area of 193.52 ha percentage of 1.12%, class III classified as moderate with an area of 1,815.52 ha percentage of 10.50%, class IV classified as heavy with an area of 682.32 ha percentage of 3.95% and class V classified as very heavy with an area of 279.56 ha percentage of 1.62%.
Study on Factors Influencing the Utilization Level of Combine Harvester by Farmers
Authors: Rangga Kordiyana K. , Efendi Irwan , Listiana Indah , Utami Tataning 
Published: July 2024

The aim of this research is to determine the level of use of combine harvesters and the factors that influence it. The research location was chosen deliberately, namely in Negeri Katon District which received assistance from 3 combine harvester units. The respondents in this study were 53 farmers from 3 farmer groups who received combine harvester assistance. The data collected was analyzed using descriptive analysis and the Kendall tau statistical test. The results of the research show that the level of use of combine harvesters on the indicators of plant condition requirements shows a good category, where farmers harvest rice when it reaches the optimum age. The indicator for plant condition requirements shows a fairly good category, where farmers harvest when the land is dry, but farmers never confirm whether the land conditions are dangerous and can damage machinery. The machine application indicator shows the poor category, where the intensity of farmers using combine harvester machines is 3 - 4 times in 5 harvest seasons, and farmers are still less skilled in operating combine harvesters. Factors related to the use of combine harvesters by farmers are land area, relative profit, compatibility, complexity, trialability, observability, and the role of farm extension workers. Keywords: Compatibility, Complexity, extension workers, Observability, Relative profit.
CONCENTRACIÓN EN NIÑOS DE 8 A 10 AÑOS POR MEDIO DE LA IMPLEMENTACIÓN DE UN PROGRAMA DE COORDINACIÓN ÓCULO-MANUAL EN EL TENIS DE MESA EN LA INSTITUCIÓN EDUCATIVA SUAZAPAWA NOBSA-BOYACÁ
Authors: Merchan Osorio Rony David , Verdugo Cusva Helman Emiro 
Published: July 2024

La presente investigación se enmarca dentro del área del entrenamiento deportivo en ámbitos educativos, el objetivo de esta investigación fue implementar un programa de coordinación oculomanual en el tenis de mesa como medio de mejoramiento de la concentración en niños de la Institución Educativa Suazapawa del municipio de Nobsa. En el estudio participaron 50 sujetos distribuidos en dos grupos de 25 integrantes cada uno. El primer grupo denominado experimental pertenecía al curso quinto c, y el segundo grupo denominado grupo control al curso quinto d, sus edades oscilan entre los 9 y los 11 años de edad, la investigación utiliza una metodología con enfoque cuantitativo con un diseño cuasi experimental, los instrumentos de evaluación utilizados fueron el test de Toulouse para medir la concentración y el ADS una batería para medir el desarrollo sensoriomotor, esto hecho en dos momentos un diagnóstico y una evaluación final luego de un tratamiento de 16 semanas en los cuales se implementa el programa de coordinación oculomanual del tenis de mesa. Para la recolección, análisis e interpretación de la información obtenida en esta investigación se utilizaron técnicas e instrumentos confiables, el análisis estadístico se realizó por medio del programa IBM SPSS en su versión más actualizada con niveles de confiabilidad del 95% las pruebas de normalidad presentaron distribución normal (p > 0,05), las pruebas realizadas fueron Shapiro-Wilk, después t-Student para ver cómo se comportaban las medias entre grupos y entre pruebas y al final se midieron los niveles de significancia entre los momentos de las evaluaciones, arrojando como hallazgos importantes, una mejoría muy significativa en el grupo experimental en relación con el grupo control luego de realizada la intervención del programa, concluyendo así que el programa en mención mejoró la concentración de los sujetos de estudio, pasando de inhibición anímica a rasgos de normalidad y fina concentración y en el desarrollo sensoriomotor pasaron con niveles altos de significancia de regular a resultados óptimos según los baremos de las pruebas de medición.
BARRERAS QUE SE ASOCIAN AL SEDENTARISMO EN LA POBLACIÓN LABORAL
Authors: García Arias Jennifer Alexandra , García Campo Mileidis Maria 
Published: July 2024

El sedentarismo y la inactividad física es la afectación mayor a nivel mundial lo cual se asocia un mayor rango de enfermedades crónicas y muertes prematuras, así mismo, el interés en la conducta sedentaria está justificada por la relación entre la conducta donde se encuentra el incremento de la prevalencia de obesidad, diabetes y enfermedad cardiovascular, es decir que a través de la historia es bien conocido que ser inactivo no es saludable, pero hoy en día un tercio de la población del mundo es inactivo, lo que representa un grave problema de salud pública ; del mismo modo, en los últimos 50 años la activada física ocupacional se ha reducido y el sedentarismo ha emergido como un factor de riesgo adicional a la inactividad física, las medidas públicas no han logrado detener la epidemia de obesidad en las últimas 3 décadas, existiendo la clara necesidad de cambiar el paradigma con el fin de prevenir de forma eficaz el aumento de la epidemia de obesidad , así mismo la inactividad física como el comportamiento sedentario tiene sus propios riesgos para la salud y deben abordarse por separado para explorar sus diferentes mecanismos nocivos donde el término «inactividad física» Tomando en consideración lo mencionado anteriormente, se llevará a cabo la redacción de un artículo de revisión con el propósito de ampliar nuestra comprensión respecto a este comportamiento en los seres humanos.
Analysis System Presensi Menggunakan RFID Card Dengan Modul Mifire RC522 Berbasis Arduino Uno
Authors: Putra Elliantosya Anugrah , Saputro Uyock Anggoro , Prasetya Wahyu Sindu 
Published: July 2024

Penelitian ini membahas tentang penggunaan sistem presensi elektronik RFID Card yang dikombinasikan dengan teknologi Arduino Uno. Metode yang digunakan adalah penelitian kualitatif dengan pendekatan studi kasus dinas lingkungan hidup dan kehutanan Kabupaten Mamasa, provinsi Sulawesi Barat. Penelitian ini menemukan bahwa
Secara keseluruhan, hasil studi literatur menunjukkan bahwa RFID card yang dikombinasikan dengan teknologi Arduino Uno adalah teknologi inovatif yang efektif dan efisien untuk digunakan sebagai sistem presensi di berbagai tempat kerja dan institusi pemerintahan.