bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD133/CD166/Ki-67 Triple Immunouorescence Assessment for Putative Cancer Stem Cells in Colon Carcinoma*
Authors: Margaritescu Claudiu , Pirici Daniel , Cherciu Irina , Barbalan Alexandru , Cârtâna Tatiana , Saftoiu Adrian 
Published: June 2014

Background & Aims: Colorectal cancer represents the third most common malignancy and the fourth most common cause of cancer death worldwide. The existence of drug-resistant colon cancer stem cells is thought to be one of the most important reasons behind treatment failure in colon cancer, their existence putatively leading to metastasis and recurrences. The aim of our study was to investigate the immunoexpression patterns of CD133 and CD166 in colon carcinoma, both individually and in combination, assessing their significance as prognostic markers.Methods. A total of 45 retrospective colon adenocarcinoma cases were investigated by enzymatic and multiple fluorescence immunohistochemistry for their CD133 and CD166 expression and colocalization.Results. Both CD133 and CD166 were expressed to different extents in all cancer specimens, with apredominant cytoplasmic pattern for CD133 and a more obvious membranous-like pattern for CD166.Overall, when comparing their reactivity for the tumoral tissue, CD166 expression areas seemed to be smaller than those of CD133. However, there was a direct correlation between CD133 and CD166 expression levels throughout the entire spectrum of lesions, with higher values for dysplastic lesions. Colocalization of CD133/ CD166 was obvious at the level of cells membranes, with higher coeficients in high grade dysplasia, followed by well and moderate differentiated tumours.Conclusions. CD133/CD166 colocalization is an early event occurring in colon tumorigenesis, with thehighest coeficients recorded for patients with high grade dysplasia, followed by well differentiated tumours. Thus, we consider that the coexpression of these two markers could be useful for further prognostic andtherapeutically stratification of patients with colon cancer.Abbreviations: AJCC - American Joint Committee on Cancer; CCD - charge-coupled device camera sensor; CD133 - prominin-1 (PROM1); CD166 - Activated Leukocyte Cell Adhesion Molecule (ALCAM); CRC - colorectal cancer; CSC - cancer stem cells; DAB - 3,3'-diaminobenzidine chromogen; DAPI - 4',6-diamidino- 2-phenylindole; HE - Hematoxylin and eosin staining; HGD - high grade dysplasia; HRP - horseradish peroxidase; LGD - low grade dysplasia; SDS - sodium dodecyl sulfate*Part of this work has been accepted as a poster presentation at the Digestive Disease Week (DDW) meeting, Chicago, IL, USA May 3-6, 2014
Increased IgA Glycoprotein-2 Specic Antibody Titres in Refractory Celiac Disease
Authors: Gross Sascha , Bakker Sjoerd F. , Van Bodegraven Adriaan A. , Van Hoogstraten Ingrid M.W. , Gelderman Kyra A. , Bouma Gerd , Mulder Chris J. , Von Blomberg B. Mary E. , Bontkes Hetty J. 
Published: June 2014

Background & Aims: In most cases celiac disease (CD) is successfully treated with a gluten-free diet (GFD). However, some patients become refractory to the GFD. Refractory CD (RCD) patients have an increased risk for developing enteropathy associated T-cell lymphoma and early diagnosis is therefore of importance. Currently, RCD diagnosis relies on endoscopy and adequate serological markers are lacking. Antibodies against glycoprotein-2 (GP2A) were described in Crohn's disease (CrD) and active CD but not in ulcerative colitis (UC), suggesting this is a specific marker for small intestinal lesions.Methods: Sera obtained from patients visiting our outpatient clinic for routine serological tests for diagnosis and/or follow-up of inflammatory bowel disease (n=78), active CD (n=45), GFD (n=34) and RCD (n=15) were analysed for GP2A titres.Results: Increased GP2A-IgA levels in CrD and active CD as compared to controls (p<0.001) and lack thereof in UC was confirmed. However, we could not confirm the association with small bowel localization within the CrD patient group. Within CD patients, we demonstrated a significant decrease of GP2A-IgA titres upon a GFD and increased levels in RCD patients as compared to patients on a GFD. Although GP2A-IgA was not associated with the degree of villous atrophy, GP2A-IgA levels were able to distinguish RCD patients from GFD patients (ROC AUC=0.79, p=0.002).Conclusion: Follow-up of GP2A-IgA titres in CD patients on a GFD may help to identify patients at risk for developing RCD.Abbreviations: ABSA: anti-bovine serum albumine; ASCA: anti- Saccharomyces cerevisiae antigen; AU:artificial units; AUC: area under the curve; CD: celiac disease; CrD: Crohn's disease; EATL: enteropathyassociated T-cell lymphoma; EmA: anti-endomysium antibodies; GFD: gluten free diet; GP2A: glycoprotein 2 antibodies; IEL: intraepithelial lymphocytes; RCD: refractory celiac disease; ROC: receiver operator curve; TG2A: transglutaminase-2 antibodies; UC: ulcerative colitis.
Neoadjuvant Conformal Chemoradiation with Induction Chemotherapy for Rectal Adenocarcinoma. A Prospective Observational Study
Authors: Fekete Zsolt , Muntean Alina-Simona , Hica Stefan , Rancea Alin , Resiga Liliana , Csutak Csaba , Todor Nicolae , Nagy Viorica Magdalena 
Published: June 2014

Background & Aims: The purpose of this prospective observational study was to evaluate the rate andthe prognostic factors for down-staging and complete response for rectal adenocarcinoma after inductionchemotherapy and neoadjuvant chemoradiation followed by surgery, and to analyze the rate of sphinctersaving surgery.Methods: We included from March 2011 to October 2013 a number of 88 patients hospitalized with locally advanced rectal adenocarcinoma in the Prof. Dr. Ion Chiricuta Institute of Oncology, Cluj. The treatment schedule included 2-4 cycles of Oxaliplatin plus a fluoropyrimidine followed by concomitant chemoradiation with a dose of 50 Gy in 25 fractions combined with a fluoropyrimidine monotherapy.Results:The rate of T down-staging was 49.4% (40/81 evaluable patients). Independent prognostic factors for T down-staging were: age >57 years (p<0.01), cN0 (p<0.01), distance from anal verge >5 cm (p<0.01), initial CEA <6.2 ng/ml (p<0.01), higher number of chemotherapy cycles with Oxaliplatin (pROC=0.05) and protraction of radiotherapy of >35 days (p<0.01). Nine patients from 81 (11.1%) presented complete response (7 pathological and 2 clinical); the independent prognostic factors were stage cT2 versus cT3-4 (p<0.01), initial tumor size ≤3.5 cm and distance from anal verge >5 cm (p=0.03). Sixty-eight patients (79.1%) underwent radical surgery and among them 35 patients (51.5 %) had a sphincter saving procedure.Conclusions: Induction chemotherapy with neoadjuvant chemoradiation produced important down-staging in rectal adenocarcinoma. Independent prognostic factors for T down-staging were: age, cN0, distance from anal verge, initial CEA, the number of Oxaliplatin cycles and duration of radiotherapy; for complete response: cT2, initial tumor size and distance from the anal verge. Abbreviations: 5FU: 5-fluorouracil; AJCC: American Joint Committee on Cancer; AV: anal verge; CAPOX: Capecitabine plus Oxaliplatin; CCR: clinical complete response; CRT: chemoradiation; CTC4.0: Common Terminology Criteria for Adverse Events, version 4.0; ECOG: Eastern Collaborative Oncology Group; EUS: endorectal ultrasound; FOLFOX: 5-fluorouracil plus Oxaliplatin; LARC: locally advanced rectal cancer; PCR: pathological complete response; PS: performance status; PTV: planning target volume; R0: Resection, 0 (microscopically clear resection margin); ROC curve: receiver operating characteristic curve; TME: total mesorectal excision; TRG: tumor regression grade.
Ṣūfī and Sultāns in Southeast Asia and Kurdistan: A Comparative Survey
Authors: Bruinessen Martin van 
Published: June 2014

This paper describes the stories about the relationship between Sufi with the king in the process of Islamization of a society that is a lot of coloring the literature in the Muslim world. This happens due to the fact that the relationship between the world religions (spiritual) with the world powers (the material) is always a problem that is somewhat typical. On the one hand, people tend to assume that a Sufi should not approach politics, because it is contrary to the ascetic world she lived.DOI: 10.15408/sdi.v3i3.798
Hasbi Ash-Shiddieqy wa Tajdīd al-Fiqh fī Indūnīsīyā
Authors: Sarjan M. Andi 
Published: June 2014

Hasbi Ash-Shiddieqy (1904-1975) was a jurist reformer. The assertion may be begging the question: how can a renewal of thought suggests Jurist. Jurisprudence Is not it synonymous with stagnation? The reaction was understandable given the jurisprudence has long been described as Islamic thought static, dogmatic, rigid, and lacking an appreciation of social change. In this paper will be assessed on the role and influence of Hasbi Ash-Shiddieqy particularly among students of Islamic studies because most of his work in the form of text books which became a popular reference them as areas of fiqh, hadith, and 'ulum al-Qur'anDOI: 10.15408/sdi.v3i3.802
Pancasila as the Sole Basis for all Political Parties and for all Mass Organizations: An Account of Muslims’ Responses
Authors: Ismail Faisal 
Published: June 2014

One of the important policy of the New Order government in the political modernization process was the introduction of Pancasila as the sole foundation for social organizations and politics in Indonesia. Policies established in 1985, is the beginning of the fading aspirarsi basis of political legitimacy-oriented civic religion. Although this policy ultimately gained remarkable success, does not mean religious people in Indonesia accept it without facing a serious crisis-crisis. It can be seen from the response at least religious people who were forced to perform a review of the legitimacy of the social and political life.DOI: 10.15408/sdi.v3i4.778
Does Traditional Islamic Malay Literature Contain Shi‘itic Elements? ‘Ali and Fātimah in Malay Hikayat Literature
Authors: Wieringa Edwin 
Published: June 2014

Many experts of classical Malay literature argues that Persian influence is known very well to the traditional Malay literature. This is evident from a number of Malay literary texts are very popular, such as Saga Bakhtiar, Hikayat Amir Hamzah, Hikayat Muhammad Hanafiyah and The Book of the Thousand Known issues is a kind of adaptation or translation even langsungdari Persian texts. Key issue of this paper is wanted to be appointed; whether there is influence in the Persian classical Malay literature was once an indication of the influence of Shiite against Sunni Islam which evolved from the beginning of the archipelago?DOI: 10.15408/sdi.v3i4.795
Ma‘had al-Juntūr Bayna al-Tajdīd wa al-Taqlīd
Authors: As'ad Mahrus 
Published: June 2014

Gontor boarding schools founded in 1926 by three brothers scholars commonly known as Trimurti, namely Ahmad Sahal, Zainuddin Fanani, and Zarkasyi. This paper will describe the development of Gontor boarding schools from the beginning has been oriented reform, in contrast with Islamic tradition that tends to traditionalists.DOI: 10.15408/sdi.v3i4.796
Sufism, Power Politics, and Reform: Al-Rānīrī’s Opposition to Hamzah al-Fanṣūrī’s Teachings Reconsidered
Authors: Vakily Abdollah 
Published: June 2014

Middle of the seventeenth century witnessed the horror of the Acehnese socio-religious life can not be imagined. These events commonly known as a fatwa banning religious follower of the teachings attributed to great figures Fansuri Hamzah. The books are used as a handle follower Hamzah collected by royal officials, stacked and burned in public. The followers themselves must bear the violence the authorities, because of being chased and forced to 'convert' to no longer follow the belief that later became known as followers of Wujudiyah.DOI: 10.15408/sdi.v4i1.788
Moenawar Khalil: The Career and Thought of Indonesian Muslim Reformist
Authors: Hamim Toha 
Published: June 2014

The study of Islamic reform movement in Indonesia in general give less attention to the genuine character is engaged outside the political arena. Various scientific papers, both national and international levels, as if not take place to the figures, although they are thought to have inspired the emergence of various new movement in Indonesian Islam. This happens not because the figures were not known to the public, but rather that the study of Islamic reform is often written and analyzed within the framework of the social-historical, while ignoring the doctrinal renewal. As a result, scientific works have forgotten the main elements of the reform, namely the intellectual insight of religious teachings.DOI: 10.15408/sdi.v4i2.779
The lslamization of Central Java: the Role of Muslim Lineages in Kalioso
Authors: Headley Stephen 
Published: June 2014

This article discusses trends and patterns of Islamization inland Javanese descent who performed a local Muslim family in Kalioso, Central Java, in the late 17th century. The question that should be asked is how the Java community process of Islamization in a smaller community level, district or rural? The pattern is used in the process of Islamization that took place at the level of the communities, especially in inland Java? Is it true that the spread of Islam in the villages also run politically, such as the establishment of the Sultanate of Demak, or take a more cultural way?DOI: 10.15408/sdi.v4i2.780
Al-Madāris al-Islāmiyyah al-Tābi‘ah li Wazārah al-Shu’ūn al-Dīniyyah ka Madāris Namūzajiyyah 1946-1987
Authors: Rahim Husni 
Published: June 2014

When the Dutch colonial period, religious education are taken care of by the two departments, namely the Department van Onderwijst en Eeredinst to religious instruction in public schools and the Department Binnenlandsche Zaken van for teaching religion in Islamic institutions, then the Indonesian independence, the two are taken care of the Department of Islamic teaching religion. The governing must have different properties. Understanding the maintenance of the colonial period was more focused on observing, supervising, and maintaining religious education so as not to harm the interests of the colonial government. Being during the Indonesian independence, the maintenance is manifested in the form of foster, assist, and promote (organization) religious education.DOI: 10.15408/sdi.v4i2.783
Islam and Indonesian Nationalism; the Political Thought of Haji Agus Salim
Authors: Kahfi Emi Haryanti 
Published: June 2014

This article discusses aspects of socio-political religious thought Haji Agus Salim. Although the main concern in the effort to synthesize Salim understanding between Islam and nationalism, this article also highlights a variety of political views. He once tried to analyze different exploits Agus Salim in the world of practical politics, religious organizations, to government posts.DOI: 10.15408/sdi.v4i3.771
Kyai and Japanese Military
Authors: Yasuko Kobayashi 
Published: June 2014

During the second world war in Southeast Asia, the Japanese army tried to gain the support and cooperation of the people it occupies. In this case the policy becomes very important political Islam in Indonesia, and one prominent characteristic of Japanese politics is concerned with the role of Islamic clerics. But when he landed in Indonesia, the Japanese military has not formulated political Islam is to be implemented. Then immediately stated that the Japanese military government respect the religious population.DOI: 10.15408/sdi.v4i3.772
Indonesian Islam between Particularity and Universality
Authors: Meuleman J.H. 
Published: June 2014

The issue of whether and to what extent Islam is part of the universal Islamic religion and civilization or a symptom of local specialties, has been answered in different ways by various scientists and politicians. The debate on this issue ever arise during the colonial era and continuing to the present.DOI: 10.15408/sdi.v4i3.773
Taṭawwur al-Ta‘līm al-‘Alī bi Indūnīsī
Authors: HS. Mastuki 
Published: June 2014

Indonesian HIgher Institution of Islamic Learning (Perguruan Tinggi Islam-PTI) was born out of Islamis struggle which started from the end the Dutch colonial period. The struggle itself was tringgered by the fact that in the 1930s the colonial goverment only established a Technical school (Technische Hoogeschool), a Law School (Rechts Hoogeschool) and a medical school (Geneeskundige Hoggeschool) at tertiary level.DOI: 10.15408/sdi.v4i3.775
Synthesis and Structural Characterization of Ferromagnetic Au/Co Nanoparticles
Authors: Bhattarai Nabraj , Khanal Subarna , Bahena Daniel , Whetten Robert L. , Jose-Yacaman Miguel 
Published: June 2014

ABSTRACTThe synthesis of bimetallic magnetic nanoparticles is very challenging because of the agglomeration and non-uniform size. In this paper, we present the synthesis of monodispersed 3-5 nm sized thiolated bimetallic alloyed Au/Co nanoparticles with decahedral and icosahedral shape, their characterization using Cs-corrected scanning transmission electron microscopy (STEM) and magnetic measurements using superconducting quantum interference device (SQUID) magnetometer. The Z-contrast imaging and energy dispersive X-ray spectroscopy (EDS) mapping showed an inhomogeneous alloying with minor segregation between Au and Co at nanoscale and the SQUID measurement exhibited the ferromagnetic behavior.
Iron Oxide-based Magnetic Nanoparticles for High Temperature Span Magnetocaloric Applications
Authors: Chaudhary V. , Ramanujan R. V. 
Published: June 2014

ABSTRACTThe magnetocaloric effect of chemically synthesized Mn0.3Zn0.7Fe2O4 superparamagnetic nanoparticles with average crystallite size of 11 nm is reported. The magnitude of the magnetic entropy change (ΔSM), calculated from magnetization isotherms in the temperature range of 30 K to 400 K, increases from - 0.16 J-kg-1K-1 for a field of 1 T to - 0.88 J-kg-1K-1 for 5 T at room temperature. Our results indicate that ΔSM values are much higher than primarily reported values for this class of nanoparticles. ΔSM is not limited to the ferromagnetic-paramagnetic transition temperature; instead, it occurs over a broad range of temperatures, resulting in high relative cooling power.
Covalent coupling of ionic liquid to carbon nanotubes: preparation and tribological properties
Authors: Taaber Triinu , Põhako-Esko Kaija , Joost Urmas , Külasalu Kadi , Antsov Mikk , Antonov Maksim , Veinthal Renno , Saal Kristjan , Lõhmus Rünno , Mäeorg Uno 
Published: June 2014

ABSTRACTA new approach for functionalising oxidised MWCNTs using hydroxylated imidazolium bromide via esterification reaction is reported. The bromide anion of a functionalised MWCNTs was exchanged with bis(trifluoromethanesulfonyl) imide (TFSI) through a metathesis reaction to improve its solubility in the IL medium. Composite was characterized with IR, XPS, EDX and TGA analysis, which clearly confirmed that the MWCNTs were functionalized with IL. For potential application as lubricant, the tribological properties of the IL-functionalised MWCNTs (MWCNT-IL) were also evaluated. It was confirmed that even low concentrations of MWCNT-IL composite in ILs causes a significant improvement in the anti-wear and friction properties.
Evaliação do impacto do programa de coleta seletiva de lixo na frequência de Calliphoridae e Muscidae em Tupã-SP
Authors: Dias Leonice Seolin , Gabriel Filho Luís Roberto Almeida , Guimarães Raul Borges 
Published: June 2014

Este trabalho discute o uso da análise de frequência de moscas das famílias Calliphoridae e Muscidae na avaliação do impacto da implantação de programas de coleta seletiva de lixo urbano. Para isto, utilizou-se do estudo de caso de Tupã, município paulista, em duas fases distintas: fase 1 - compreendida entre os meses de junho e outubro de 2001, período caracterizado pela presença do lixão e; fase 2 - entre os meses de novembro de 2001 a maio de 2002, caracterizada pelo início da implantação do processo de coleta seletiva e reciclagem e aterramento gradativo do lixão. Procedeu-se a captura dos insetos com dez armadilhas confeccionadas com garrafas plásticas, de dois litros, do tipo PET, alocadas em residências e árvores ao redor do lixão. Como atrativo utilizou-se aproximadamente 400 ml de vinhaça de cana de açúcar, substituída semanalmente no ato da colheita. Nas duas fases da pesquisa, observou-se que a família mais frequente e constante foi a Calliphoridae. Houve correlação positiva, antes da coleta seletiva, entre o número de califorídeos e a precipitação pluviométrica (0,638) e, entre o número de muscídeos e a temperatura média (0,605). Após a coleta, o mesmo não foi observado. O programa de coleta seletiva implantado nesse município paulista resultou em diminuição significativa na frequência de dípteros e a análise da flutuação de califorídeos e muscídeos demonstrou-se como um eficiente indicador de monitoramento da qualidade ambiental.
Pattern of Egg Maturation and Oviposition forMicroplitis rufiventris(Hymenoptera: Braconidae) Wasps Given Different Schedules of Host Availability and Food Resources
Authors: Hegazi Esmat , Khafagi Wedad , Schlyter Fredrik 
Published: June 2014

AbstractThe effects of the oviposition regime on egg maturation rate in the synovigenic parasitoid, Microplitis rufiventris Kokujev were investigated. In non-ovipositing wasps, females normally reach a peak of egg maturation rate on 1 d posteclosion. Egg maturation slowed down once the maximum oviduct egg load was reached on 2 d posteclosion. In wasps manipulated for 20 ovipositions per day, the egg maturation rate during the first 3 d posteclosion was lower compared with those manipulated for 40 ovipositions per day. The rate of egg maturation in 1-d-old wasps was found to be the highest for those that experienced 60 ovipositions per day. The maturation rate in females offered unlimited hosts was not significantly greater than those manipulated for 40 ovipositions per day. The act of oviposition significantly increased the rate of egg maturation and minimized egg resorption in the female wasp. The distribution of mature eggs in the ovaries at death is apparently associated with the oviposition regime. Trade-offs between egg maturation rate and female longevity were quite evident.
Using a New Spectroscopy Tool to Quantify Elemental Concentrations and TOC in an Unconventional Shale Gas Reservoir: Case Studies from Saudi Arabia
Authors: Al-Salim Ahmed , Meridji Yacine , Musharfi Nedhal , Al-Waheed Hilal , Saldungaray Pablo , Herron Susan , Polyakov Marina 
Published: June 2014

Abstract
The increasing complexity of today's reservoirs requires a good understanding of a formation's mineralogy to make an accurate petrophysical analysis. This is particularly true in the case of unconventional reservoirs, for which the quantification of both mineralogy and organic carbon content is critical to confidently appraise and develop new prospects.
A new spectroscopy tool is being applied to evaluate challenging shale gas reservoirs. The new measurements quantify key mineral-forming elements with higher precision and accuracy than previously possible. The new technology provides a direct determination of total organic carbon (TOC), which is an important parameter in the evaluation of kerogen-rich unconventional reservoirs.
Accurate lithology and kerogen volumes ultimately affect the estimation of porosity and free and adsorbed gas saturations, which are critical for evaluating resources and planning for further field development. Mineralogy can also be used in geomechanical models to determine completion quality, design stimulation operations, and specify intervals for perforation.
The results obtained show excellent agreement with core data for TOC, elemental concentrations, and mineral abundances. One of the main advantages of computing TOC directly from carbon is that it does not require calibration to core data as do empirical methods based on local correlations that use more indirect measurements such as bulk density, sonic-resistivity overlay, or uranium concentration. The robustness of the proposed direct carbon approach is illustrated by comparing it with core and well-established methods for estimating TOC, such as the Schmoker technique.