bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between higher social support and lower depressive symptoms among aging services clients is attenuated at higher levels of functional impairment
Authors: Van Orden Kimberly A. , Li Yan , Podgorski Carol A. , Conwell Yeates 
Published: February 2015

ObjectiveAdults seeking services from the Aging Services Provider Network (ASPN) are at risk for depression. ASPN clients also have high prevalence of both functional impairments and social morbidities. Study of the relationships between these factors may inform the development of interventions for depression in this service setting.MethodsWe interviewed 373 older adults accessing ASPN services and assessed depression symptom severity, functional impairment (instrumental activities of daily living and activities of daily living), and social support.ResultsLower social support and greater functional impairment were associated with greater depressive symptoms. At a high level of functional impairment, the inverse associations between indices of social support and depressive symptoms were attenuated.ConclusionsResults suggest that older adults with more severe functional impairment may benefit somewhat less from increased social support with respect to depression symptom severity. Copyright © 2015 John Wiley & Sons, Ltd.
An Organotin(IV) Carboxylate Based on Amide Carboxylic Acid: Synthesis, Crystal Structure, and Characterizations
Authors: Sougoule Aboubacar Sidiki , Xiao Xiao , Balde Cheick Abdoul , Sakho Adama Moussa , Zhu Dongsheng 
Published: February 2015

ABSTRACTAn organotin carboxylate based on amide carboxylic acid (Ph3Sn)(L)·C7H8 (complex 1) (HL = 3‐(1,3‐dioxo‐1H,3H‐benzo[de]isoquinolin‐2‐yl)propanoic acid) has been synthesized and characterized by elemental analyses (IR, 1H, 13C, and 119Sn NMR), UV–visible spectroscopies, and X‐ray crystallography diffraction analysis. Complex 1 is a monomeric triphenyltin carboxylate. Ligand HL in complex 1 adopts unidentate coordination mode. Intermolecular hydrogen bonds and CH···π interactions help complex 1 to build fascinating one‐dimensional and two‐dimensional structures, which are discussed in detail.
Ergonomists’ and Engineers’ Views on the Utility of Virtual Human Factors Tools
Authors: Perez J. , Neumann W. P. 
Published: February 2015

AbstractA qualitative research study was conducted through explorative workshops to better understand the experiences, perceptions, needs, and expectations of the users and potential users of virtual human factors (VHF) tools. Five VHF tools were presented to ergonomists, engineers, and managers who participated in four whole‐day interactive workshops: HF enabled predetermined motion time systems (PMTS), discrete event simulation (DES), complex and simple digital human models (DHM), and virtual reality (VR). Data were collected by note‐takers, digital audio recording, and written feedback. Identified characteristics shared by the tools were organized into 9 categories that act as a motivational or deterring factor for the use of the tool: time, cost, training, difficulty of use, trustworthiness, graphics, flexibility, usefulness, and report presentation. Other tool specific areas of improvement were also identified by participants to help developers improve these design instruments.
LithiumOxygen Electrochemistry in Non‐Aqueous Solutions
Authors: Sharon Daniel , Hirshberg Daniel , Afri Michal , Garsuch Arnd , Frimer Aryeh A. , Aurbach Doron 
Published: February 2015

AbstractPairing lithium and oxygen in aprotic solvents can theoretically lead to one of the most promising electrochemical cells available. If successful, this system could compete with technologies such as the internal combustion engine and provide an energy density that can accommodate electric vehicle demands. However, there are many problems that have inhibited this technology from becoming realistic. One of the main reasons is capacity fading after only a few cycles, which is caused by the instability of electrolyte solutions in the presence of reduced oxygen species like O2.− and O22−. In recent years, using various analytical tools, researchers have been able to isolate the breakdown products arising from the reactions occurring between the aprotic solvent and the reduced oxygen species. Nevertheless, no solvents have yet been found that are fully stable throughout the reduction and oxidation processes. However, an understanding of these decomposition mechanisms can help us in designing new systems that are more stable toward the aggressive conditions taking place in LiO2 cell operation. This review will include analytical studies on the most widely used solvents in current LiO2 research.
Evaluation of metronidazole‐loaded poly(3‐hydroxybutyrate) membranes to potential application in periodontitis treatment
Authors: da Silva Marcio A. C. , Oliveira Renata N. , Mendonça Roberta Helena , Lourenço Talita G. B. , Colombo Ana Paula V. , Tanaka Marcelo N. , Tude Elena M. O. , da Costa Marysilvia F. , Thiré Rossana Mara S. M. 
Published: February 2015

AbstractGuided tissue regeneration is a technique used for periodontium reconstruction. This technique uses barrier membranes, which prevent epithelial growth in the wound site and may also be used to release antibiotics, to protect the wound against opportunistic infections. Periodontal poly(3‐hydroxybutyrate) membranes containing metronidazole (a drug used to help in infection control) were produced and characterized. The kinetic mechanism of the metronidazole delivery of leached and nonleached membrane as well as its cytotoxicity and structural integrity were evaluated. Poly(3‐hydroxybutyrate) membranes containing 0.5–2 wt % of the drug and 20 wt % of the plasticizer were manufactured via compression molding. Based on morphological analysis, membranes loaded with 2% metronidazole were considered for detailed studies. The results revealed that metronidazole delivery by the leached membranes seemed to follow the Fick's law. Membranes were noncytotoxic. The amount of metronidazole delivered was in the range of the minimal inhibitory concentration for Porphyromonas gingivalis, and the membranes inhibited the proliferation of these bacteria. Besides, they maintained their mechanical resistance after 30 days of immersion in phosphate buffer at pH 7.4. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 106–115, 2016.
Muscle and Bone Impairment in Children With Marfan Syndrome: Correlation With Age and FBN1 Genotype
Authors: Haine Elsa , Salles Jean-Pierre , Khau Van Kien Philippe , Conte-Auriol Françoise , Gennero Isabelle , Plancke Aurélie , Julia Sophie , Dulac Yves , Tauber Maithé , Edouard Thomas 
Published: February 2015

ABSTRACT

Marfan syndrome (MFS) is a rare connective tissue disorder caused by mutation in the gene encoding the extracellular matrix protein fibrillin-1 (FBN1), leading to transforming growth factor-beta (TGF-β) signaling dysregulation. Although decreased axial and peripheral bone mineral density (BMD) has been reported in adults with MFS, data about the evolution of bone mass during childhood and adolescence are limited. The aim of the present study was to evaluate bone and muscle characteristics in children, adolescents, and young adults with MFS. The study population included 48 children and young adults (22 girls) with MFS with a median age of 11.9 years (range 5.3 to 25.2 years). The axial skeleton was analyzed at the lumbar spine using dual-energy X-ray absorptiometry (DXA), whereas the appendicular skeleton (hand) was evaluated using the BoneXpert system (with the calculation of the Bone Health Index). Muscle mass was measured by DXA. Compared with healthy age-matched controls, bone mass at the axial and appendicular levels and muscle mass were decreased in children with MFS and worsened from childhood to adulthood. Vitamin D deficiency (&lt;50 nmol/L) was found in about a quarter of patients. Serum vitamin D levels were negatively correlated with age and positively correlated with lumbar spine areal and volumetric BMD. Lean body mass (LBM) Z-scores were positively associated with total body bone mineral content (TB-BMC) Z-scores, and LBM was an independent predictor of TB-BMC values, suggesting that muscle hypoplasia could explain at least in part the bone loss in MFS. Patients with a FBN1 premature termination codon mutation had a more severe musculoskeletal phenotype than patients with an inframe mutation, suggesting the involvement of TGF-β signaling dysregulation in the pathophysiologic mechanisms. In light of these results, we recommend that measurement of bone mineral status should be part of the longitudinal clinical investigation of MFS children. © 2015 American Society for Bone and Mineral Research.
A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3+ CD8 T Cells
Authors: Buchwald Zachary S , Yang Chang , Nellore Suman , Shashkova Elena V , Davis Jennifer L , Cline Anna , Ko Je , Novack Deborah V , DiPaolo Richard , Aurora Rajeev 
Published: February 2015

ABSTRACT

TNF-α and IL-17 secreted by proinflammatory T cells (TEFF) promote bone erosion by activating osteoclasts. We previously demonstrated that in addition to bone resorption, osteoclasts act as antigen-presenting cells to induce FoxP3 in CD8 T cells (TcREG). The osteoclast-induced regulatory CD8 T cells limit bone resorption in ovariectomized mice (a murine model of postmenopausal osteoporosis). Here we show that although low-dose receptor activator of NF-κB ligand (RANKL) maximally induces TcREG via Notch signaling pathway to limit bone resorption, high-dose RANKL promotes bone resorption. In vitro, both TNF-α and IL-17, cytokines that are abundant in ovariectomized animals, suppress TcREG induction by osteoclasts by repressing Notch ligand expression in osteoclasts, but this effect can be counteracted by addition of RANKL. Ovariectomized mice treated with low-dose RANKL induced TcREG that suppressed bone resorption, decreased TEFF levels, and increased bone formation. High-dose RANKL had the expected osteolytic effect. Low-dose RANKL administration in ovariectomized mice lacking CD8 T cells was also osteolytic, confirming that TcREG mediate this bone anabolic effect. Our results show that although RANKL directly stimulates osteoclasts to resorb bone, it also controls the osteoclasts' ability to induce regulatory T cells, engaging an important negative feedback loop. In addition to the conceivable clinical relevance to treatment of osteoporosis, these observations have potential relevance to induction of tolerance and autoimmune diseases. © 2015 American Society for Bone and Mineral Research.
Effects of the contraceptive skin patch and subdermal contraceptive implant on markers of endothelial cell activation and inflammation
Authors: Hernandez‐Juarez Jesus , Sanchez‐Serrano Juan Carlos , Moreno‐Hernandez Manuel , Alvarado‐Moreno Jose Antonio , Hernandez‐Lopez Jose Rubicel , Isordia‐Salas Irma , Majluf‐Cruz Abraham 
Published: February 2015

AbstractChanges in blood coagulation factors may partially explain the association between hormonal contraceptives and thrombosis. Therefore, the likely effects of the contraceptive skin patch and subdermal contraceptive implant on levels of inflammatory markers and endothelial activation were analyzed. This was an observational, prospective, longitudinal, nonrandomized study composed of 80 women between 18 and 35 years of age who made the decision to use the contraceptive skin patch or subdermal contraceptive implant. vascular cell adhesion molecule‐1 (VCAM‐1), endothelial cell leukocyte adhesion molecule‐1 (ELAM‐1), von Willebrand factor (VWF), and plasminogen activator inhibitor type 1(PAI‐1) as well as high‐sensitivity C‐reactive protein (hsCRP) were assayed before and after 4 months of use of the contraceptive method. VCAM‐1, VWF, and PAI‐1 remained unchanged in the contraceptive skin patch group; however, a significant increase in hsCRP (0.29–0.50 mg/dL; P =.012) and a significant decrease in ELAM‐1 (44–25 ng/mL; P =.022) were observed. A significant diminution in VCAM‐1 (463–362 ng/mL; P =.022) was also found in the subdermal contraceptive implant group. Our results strongly suggest that these contraceptive methods do not induce endothelial activation after 4 months of use. Increase in hsCRP levels was unrelated to changes in markers of endothelial activation.
Use of quantitative MRI for the detection of progressive cartilage degeneration in a mini‐pig model of osteoarthritis caused by anterior cruciate ligament transection
Authors: Wei Bo , Zong Min , Yan Chao , Mao Fengyong , Guo Yang , Yao Qingqiang , Xu Yan , Wang Liming 
Published: February 2015

BackgroundTo investigate the progression of cartilage degeneration using delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) and T2 mapping in a mini‐pig model of osteoarthritis (OA) caused by anterior cruciate ligament transection (ACLT).MethodsTwelve mini‐pigs underwent ACLT in the left knee and were monitored by dGEMRIC (T1, gadolinium [Gd]) and T2 mapping after 2, 4, or 6 weeks (n = 4 each). No ACLT surgery was performed in four healthy control mini‐pigs, which were also monitored by dGEMRIC and T2 mapping. Cartilage samples from the weight‐bearing regions of the left medial femoral condyles were collected for macroscopic, histological, immunohistochemical, and biochemical analysis. Correlations between biochemical contents and T1,Gd and T2 values were evaluated using Pearson correlation analysis.ResultsT1,Gd values were gradually reduced and T2 values increased over time. Cartilage surfaces showed roughness at 4 weeks and additional defects at 6 weeks. Glycosaminoglycan (GAG) distribution and content gradually reduced over time (P < 0.05), and collagen distribution and anisotropy were obviously changed at 6 weeks. However, collagen content did not differ significantly among postoperative timepoints. GAG content was positively related to T1,Gd values (r = 0.888; P < 0.001) and negatively related to T2 values (r = −0.865; P < 0.001). Collagen content had no discernible correlation with T1,Gd or T2 values.ConclusiondGEMRIC and T2 mapping can monitor the progression of cartilage degeneration in a mini‐pig model of ACLT‐induced OA, permitting early detection of OA. J. Magn. Reson. Imaging 2015;42:1032–1038.
Ensemble homogenization of Slovenian monthly air temperature series
Authors: Vertačnik Gregor , Dolinar Mojca , Bertalanič Renato , Klančar Matija , Dvoršek Damjan , Nadbath Mateja 
Published: February 2015

ABSTRACTThis paper presents an attempt to obtain high‐quality data series of monthly air temperature for Slovenian stations network in the period from 1961 to 2011. Intensive quality control procedure was applied to mean, maximum and minimum air temperature datasets from the Slovenian Environment Agency. Recently developed semi‐automatic homogenization tool HOMER (HOMogenisation softwarE in R) was used to homogenize the selected high‐quality datasets. To estimate the reliability of homogenized datasets, three to six experts independently homogenized the same datasets or their subsets. Different homogenization parameter settings were used by each of the experts, thus comprising ensemble homogenization experiment. Resulting datasets were compared by break statistics, root‐mean‐squared‐difference (RMSD) of monthly and annual values, and RMSD of the long‐term trend. This semi‐automatic homogenization approach based on metadata gave more reliable homogenization results than a fully automatic approach without metadata. While the network‐wide linear trend of the dataset did not change after semi‐automatic homogenization was applied, the distribution of the trends of individual stations became spatially more uniform. The arithmetic mean of the homogenized datasets of three experts was assigned as a reference homogenized dataset and it was compared with some publicly available homogenized datasets. The calculated linear trend on an annual level for Slovenia is strongly positive in all datasets, though the trend values are significantly different between the datasets. We conclude that the warming trend of near‐surface air temperature in Slovenia in 1961–2011 is significant and unequivocal in all seasons, except for autumn. Mean, maximum and minimum temperature series indicate linear trend of around 0.3–0.4 °C decade–1 on an annual level.
The time factor in the LDI (Laser Doppler Imaging) diagnosis of burns
Authors: Štětinský Jiří , Klosová Hana , Kolářová Hana , Šalounová Dana , Bryjová Iveta , Hledík Stanislav 
Published: February 2015

Background and ObjectiveThe not quite rare occurrence of inaccurate clinical diagnoses of burns in early post‐burn days leads to an inappropriate conservative treatment strategy, or unnecessary surgery. LDI (Laser Doppler Imaging) objectively evaluates skin blood circulation, which correlates with the depth of the burn and the length of healing. The aim of this work was to suggest cutoff values for detecting burns without healing potential within 3 weeks, which should have undergone surgery.MethodThe burned area's average blood perfusion of 148 burns was measured on 115 patients, using the Laser Doppler Imager PIM III. A total of 268 measurements were performed from the one to the ninth post‐burn day (PBD). The perfusion values were compared to the healing time or histology in the case of the surgical treatment. Cutoff values indicating surgery were investigated in various post‐burn days; the ROC analysis was used.ResultsThis work suggest statistically significant increasing cutoff values for indication to surgery (P = 0.05). From the third to the fifth day 148.5 perfusion units (PU), from the sixth to the seventh day 186.0 PU, from the eighth to the ninth PBD 269.5 PU. The cutoff value is not possible to establish until the second day.ConclusionLDI is a useful method for wound healing prediction and an indication of the necessity of surgery. We have demonstrated that the diagnosis of the healing capacity of LDI needs to take into account the factor of time. Lasers Surg. Med. 47:196–202, 2015. © 2015 Wiley Periodicals, Inc.
Efficacy and safety of laser therapy on axillary hyperhidrosis after one year follow‐up: A randomized blinded controlled trial
Authors: Leclère Franck Marie , Moreno‐Moraga Javier , Alcolea Justo M. , Vogt Peter M. , Royo Josefina , Cornejo Paloma , Casoli Vincent , Mordon Serge , Trelles Mario A. 
Published: February 2015

IntroductionHyperhidrosis is a debilitating problem that is not only uncomfortable and inconvenient, but also embarrassing in work and social situations. In spite of the availability of several options for the treatment of axillary hyperhidrosis, recently, there has been an increasing interest in the use of laser therapy. This study aims to evaluate the efficacy of a laser diode device emitting at wavelengths of 924 and 975 nm and classical curettage either alone, simultaneously or in combination.Material and methodsA randomized prospective controlled trial was carried out on 100 patients divided into four groups, each with a different protocol: Laser alone at 975 nm (group 1), laser alone at 924/975 nm simultaneously (group 2), curettage alone (group 3), and finally laser at 924/975 nm followed by curettage (group 4). HDSS, starch test and GAIS were used to assess treatment efficacy. The follow‐up extended to one year. Statistical analysis (SPSS) was used to determine the accuracy of the results.ResultTwo patients of group 1 experienced burns during treatment, which took over a month to heal. This group of patients achieved the worst results: The starch test scale results after treatment were 2.48 ± 0.51 and 2.76 ± 0.44 (at 1 and 12 months). The GAIS results were 1.04 ± 0.35 and 0.92 ± 0.28 (1 and 12 months). In group 2 the starch test scale results after treatment were 1.36 ± 0.49 and 1.48 ± 0.51 (at 1 and 12 months). The GAIS results were 2.36 ± 0.49 and 2.72 ± 0.46 (at 1 and 12 months). In group 3, the starch test scale results after treatment were 1.56 ± 0.51 and 1.76 ± 0.60 (at 1 and 12 months), which corresponds to small to substantially smaller dark areas. The GAIS results were 2.28 ± 0.46 and 2.64 ± 0.49 (at 1 and 12 months). The best results were obtained in group 4: HDSS scores were reduced from 3.88 ± 0.33 before treatment to 1.24 ± 0.44 and 0.48 ± 0.51 at the 1 and 12 months controls. The starch test scale results after treatment were 0.40 ± 0.50 and 0.44 ± 0.51 (at 1 and 12 months). The GAIS results were 3.72 ± 0.54 and 3.76 ± 0.44 (at 1 and 12 months).ConclusionIn this study, the laser at 924/975 nm combined with curettage was determined to be the optimal treatment option of those tested for axillary hyperhidrosis. This treatment was safe, with few side effects and improvement that persisted to one year follow‐up. Lasers Surg. Med. 47:173–179, 2015. © 2015 Wiley Periodicals, Inc.
Installation of Zwitterionic α‐Amino Phosphonic Acid Moieties on Surfaces via a Kabachnik‐Fields Post‐Polymerization Modification
Authors: Wagner Natalie , Schneider Lilli , Michelswirth Martin , Küpper Karsten , Theato Patrick 
Published: February 2015

An organic–inorganic hybrid polymer, composed of poly(methylsilsesquioxane) (PMSSQ) and poly(4‐vinyl benzaldehyde) (PStCHO), is prepared by reversible addition–fragmentation chain transfer (RAFT) polymerization of 4‐vinyl benzaldehyde (StCHO) using a macro‐chain transfer agent (CTA) based on PMSSQ. The obtained PMSSQ–PStCHO is spin‐coated on substrates such as silicon wafers or copper plates to afford aldehyde‐functionalized surfaces. Successful Kabachnik‐Fields post‐polymerization modification (KF‐PMR) of the aldehyde‐functionalized surfaces is conducted with amines and dialkyl phosphonates, and characterized by surface analysis techniques including IR, energy‐dispersive X‐ray (EDX), and X‐ray photoelectron spectroscopy (XPS) measurements, documenting the installation of α‐amino phosphonates onto surfaces with practically quantitative conversion of aldehydes. In addition, the generated α‐amino phosphonates are successfully deprotected to afford the corresponding α‐amino phosphonic acids on surfaces, which make this route a reliable tool‐enabling surface functionalization with α‐amino phosphonic acids.
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Towards Hydrogen Evolution Initiated by LED Light: 2‐(1H‐1,2,3‐Triazol‐4‐yl)pyridine‐Containing Polymers as Photocatalyst
Authors: Happ Bobby , Kübel Joachim , Pfeffer Michael G. , Winter Andreas , Hager Martin D. , Dietzek Benjamin , Rau Sven , Schubert Ulrich S. 
Published: February 2015

Two‐ and three‐component polymethacrylates, featuring a 2‐(1‐substituted‐1H‐1,2,3‐triazol‐4‐yl)pyridine‐based metal complex as photosensitizer, a viologen‐type electron mediator, and a triethylene glycol methyl ether as solubilizing part are synthesized by statistical reversible addition–fragmentation chain transfer (RAFT) radical polymerization allowing the construction of well‐defined copolymers. Thereby, heteroleptic ruthenium(II) and iridium(III) complexes serve as charged photosensitizers. In hydrogen evolution experiments, as proof‐of‐concept, triethylamine is utilized as a sacrificial donor and colloidal platinum as hydrogen evolving catalyst. The macromolecules bearing heteroleptic iridium(III) complexes of the general formula [Ir(ppy)2(trzpy)]PF6 (ppy: 2‐phenylpyridine; trzpy: 2‐(1‐substituted‐1H‐1,2,3‐triazol‐4‐yl)pyridine) and [Ir(btac)2(trzpy)]PF6 (btac: 3‐(2‐benzothiazolyl)‐7‐(diethylamino)coumarin) are photocatalytically active producing molecular hydrogen in water upon illumination at 470 nm. By changing the cyclometalating ligand from ppy to btac, the photocatalytic performance of the copolymer as reflected in the turnover number increases by two orders of magnitude.
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