bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glioblastoma complicated by fatal malignant acute ischemic stroke: MRI finding to assist in tricky surgical decision
Authors: Amelot Aymeric , Baronnet-Chauvet Flore , Fioretti Edith , Mathon Bertrand , Cornu Philippe , Nouet Aurélien , Chauvet Dorian 
Published: August 2015

Background In most cases, glioblastomas are associated with seizures, headaches, neurological deficits, aphasia, or bleeding. But these tumors are rarely associated with cerebral infarction and never so deadly. Case report A 40-year-old man presented with sudden morning isolated aphasia. One hour later, he developed a motor deficit at right upper member, quickly completed with a total right hemiplegia. Imaging studies revealed a left frontotemporal enhancing glioblastoma with a perilesional edema which produced an important mass effect on the posterior arm of the external capsule, on the primary motor cortex posteriorly and the entire sylvian valley anteriorly. Due to major surgical risks associated with left middle cerebral artery (MCA) inclusion and large edema, we decided to postpone the tumor removal and introduce quickly high concentrations of steroids. Twenty-four hours after his admittance, the patient presented a sudden impaired consciousness, coma, and a left mydriasis. A brain magnetic resonance image (MRI) revealed a left malignant MCA infarction, deadly for the patient. Conclusion To our knowledge, glioblastomas complicated by fatal ischemic stroke have not been reported. We discuss the pathology of such an event and try to figure out if it was predictable based on MRI finding, and inevitable with precocious surgery.
Cell of origin of transformed follicular lymphoma
Authors: Kridel Robert , Mottok Anja , Farinha Pedro , Ben-Neriah Susana , Ennishi Daisuke , Zheng Yvonne , Chavez Elizabeth A. , Shulha Hennady P. , Tan King , Chan Fong Chun , Boyle Merrill , Meissner Barbara , Telenius Adele , Sehn Laurie H. , Marra Marco A. , Shah Sohrab P. , Steidl Christian , Connors Joseph M. , Scott David W. , Gascoyne Randy D. 
Published: August 2015

Key Points
TFL is most commonly of the germinal center B-cell-like phenotype, but a significant minority of cases is of the ABC phenotype (16%). The absence of BCL2 translocation in FL at diagnosis is associated with transformation into ABC-like large cell lymphoma.
Increased exposure to acute thermal stress is associated with a non-linear increase in recombination frequency and an independent linear decrease in fitness in Drosophila
Authors: Jackson Savannah , Nielsen Dahlia M. , Singh Nadia D. 
Published: August 2015

AbstractBackgroundMeiotic recombination rate has long been known to be phenotypically plastic. How plastic recombination evolves and is maintained remains controversial; though a leading model for the evolution of plastic recombination rests on the tenet that organismal fitness and recombination frequency are negatively correlated. Motivated by the mounting evidence that meiotic recombination frequencies increase in response to stress, here we test for a negative correlation between fitness and recombination frequency. Specifically, the fitness-associated recombination model (FAR) predicts that if stress increases meiotic recombination frequency, then increasing exposure to stressful conditions will yield an increasing magnitude of the recombinational response, while concomitantly decreasing fitness.ResultsWe use heat shock as a stressor to test this prediction inDrosophila melanogaster. We find that increased exposure to heat shock conditions is associated with a non-linear increase in meiotic recombination frequency. We also find an independent effect of heat shock on organismal fitness, with fitness decreasing with increased duration of thermal stress.ConclusionsOur results thus support the foundation of the FAR model for the evolution of plastic recombination. Our data also suggest that modulating recombination frequency is one mechanism by which organisms can rapidly respond to environmental cues and confer increased adaptive potential to their offspring.
Improving medication adherence in stroke patients through Short Text Messages (SMS4Stroke)-study protocol for a randomized, controlled trial
Authors: Kamal Ayeesha Kamran , Shaikh Quratulain Nauman , Pasha Omrana , Azam Iqbal , Islam Muhammad , Memon Adeel Ali , Rehman Hasan , Affan Muhammad , Nazir Sumaira , Aziz Salman , Jan Muhammad , Andani Anita , Muqeet Abdul , Ahmed Bilal , Khoja Shariq 
Published: August 2015

Abstract
Background
Stroke is a major cause of morbidity and mortality, especially in low and middle income countries. Medical management is the mainstay of therapy to prevent recurrence of stroke. Current estimates are that only 1 in 6 patients have perfect adherence to medication schedules. Using SMS (Short Messaging Service) as reminders to take medicines have been used previously for diseases such as diabetes and HIV with moderate success. We aim to explore the effectiveness and acceptability of SMS in increasing adherence to medications in patients with stroke.

Methods
This will be a randomized, controlled, assessor blinded single center superiority trial. Adult participants with access to a cell phone and a history of stroke longer than 1 month on multiple risk modifying medications will be selected from Neurology and Stroke Clinic. They will be randomized into two parallel groups in a 1:1 ratio via block technique with one group receiving the standard of care as per institutional guidelines while the parallel group receiving SMS reminders for each dose of medicine in addition to the standard of care. In addition intervention group will receive messages for lifestyle changes, medication information, risk factors and motivation for medication adherence. These will bemodeled on Social Cognitive Theory and Health Belief Model and will be categorized by Michies Taxonomy of Behavioral Change Communication. Patient compliance to medicines will be measured at baseline and then after 2 months in each group by using the Morisky Medication Adherence Scale. The change in compliance to medication regimen after the intervention and the difference between the two groups will be used to determine the effectiveness of SMS reminders as a tool to increase medication compliance. The acceptability of the SMS will be determined by a tool designed for this study whose attributes are based Rogers Diffusion of innovation theory.
A sample size of 86 participants in each arm will be sufficient to detect a difference of 1 point on the MMAS with a power of 90 % and significance level of 5 % between the two groups; using an attrition rate of 15 %, 200 participants in all will be randomized.

Discussion
The SMS for Stroke Study will provide evidence for feasibility and effectiveness of SMS in improving post stroke medication adherence in an LMIC setting.

Trial registration
https://clinicaltrials.gov/ct2/show/NCT01986023 11 /11/2013
YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells
Authors: Jiang Wen G. , Ye Lin , Ruge Fiona , Owen Sioned , Martin Tracey , Sun Ping-Hui , Sanders Andrew J. , Lane Jane , Satherley Lucy , Weeks Hoi P. , Gao Yong , Wei Cong , Wu Yiling , Mason Malcolm D. 
Published: August 2015

Abstract
Background
Hepatocyte growth factor (HGF)
is a cytokine that has a profound effect on cancer cells by stimulating migration and invasion and acting as an angiogenic factor. In lung cancer, the factor also plays a pivotal role and is linked to a poor outcome in patients. In particular, HGF is known to work in combination with EGF on lung cancer cells. In the present study, we investigated the effect of a traditional Chinese medicine reported in cancer therapies, namely YangZheng XiaoJi (YZXJ) on lung cancer and on HGF mediated migration and invasion of lung cancer cells.

Methods
Human lung cancer cells, SKMES1 and A549 were used in the study. An extract from the medicine was used. Cell migration was investigated using the EVOS and by ECIS. Cell–matrix adhesion and in vitro invasion were assessed. In vivo growth of lung cancer was tested using an in vivo xenograft tumour model and activation of the HGF receptor in lung tumours by an immunofluorescence method.

Results
Both lung cancer cells increased their migration in response to HGF and responded to YZXJ by reducing their speed of migration. YZXJ markedly reduced the migration and in vitro invasiveness induced by HGF. It worked synergistically with PHA665752 and SU11274, HGF receptor inhibitors on the lung cancer cells both on HGF receptor activation and on cell functions. A combination of HGF and EGF resulted in a greater increase in cell migration, which was similarly inhibited by YZXJ, and in combination with the HGF receptor and EGF receptor inhibitors. In vivo, YZXJ reduced the rate of tumour growth and potentiated the effects of PHA665752 on tumour growth. It was further revealed that YZXJ significantly reduced the degree of phosphorylation of the HGF receptor in lung tumours.

Conclusion
YZXJ has a significant role in reducing the migration, invasion and in vivo tumour growth of lung cancer and acts to inhibit the migratory and invasive effects induced by HGF and indeed by HGF/EGF. This effect is likely attributed to the inhibition of the HGF receptor activation. These results indicate that YZXJ has a therapeutic role in lung cancer and that combined strategy with methods to block HGF and EGF should be considered.
Small-Conductance Calcium-Activated Potassium (SK) Channels in the Amygdala Mediate Pain-Inhibiting Effects of Clinically Available Riluzole in a Rat Model of Arthritis Pain
Authors: Thompson Jeremy M. , Ji Guangchen , Neugebauer Volker 
Published: August 2015

Background Arthritis pain is an important healthcare issue with significant emotional and affective consequences. Here we focus on potentially beneficial effects of activating small-conductance calcium-activated potassium (SK) channels in the amygdala, a brain center of emotions that plays an important role in central pain modulation and processing. SK channels have been reported to regulate neuronal activity in the central amygdala (CeA, output nucleus). We tested the effects of riluzole, a clinically available drug for the treatment of amyotrophic lateral sclerosis, for the following reasons. Actions of riluzole include activation of SK channels. Evidence in the literature suggests that riluzole may have antinociceptive effects through an action in the brain but not the spinal cord. Mechanism and site of action of riluzole remain to be determined. Here we tested the hypothesis that riluzole inhibits pain behaviors by acting on SK channels in the CeA in an arthritis pain model. Results Systemic (intraperitoneal) application of riluzole (8 mg/kg) inhibited audible (nocifensive response) and ultrasonic (averse affective response) vocalizations of adult rats with arthritis (5 h postinduction of a kaolincarrageenan monoarthritis in the knee) but did not affect spinal withdrawal thresholds, which is consistent with a supraspinal action. Stereotaxic administration of riluzole into the CeA by microdialysis (1 mM, concentration in the microdialysis fiber, 15 min) also inhibited vocalizations, confirming the CeA as a site of action of riluzole. Stereotaxic administration of a selective SK channel blocker (apamin, 1 μM, concentration in the microdialysis fiber, 15 min) into the CeA had no effect by itself but inhibited the effect of systemic riluzole on vocalizations. Off-site administration of apamin into the basolateral amygdala (BLA) as a placement control or stereotaxic application of a selective blocker of large-conductance calcium-activated potassium (BK) channels (charybdotoxin, 1 μM, concentration in the microdialysis fiber, 15 min) into the CeA did not affect the inhibitory effects of systemically applied riluzole. Conclusions The results suggest that riluzole can inhibit supraspinally organized pain behaviors in an arthritis model by activating SK, but not BK, channels in the amygdala (CeA but not BLA).
Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming
Authors: Quesenberry Peter J. , Aliotta Jason , Deregibus Maria Chiara , Camussi Giovanni 
Published: August 2015

AbstractGrowing evidence suggests that transcriptional regulators and secreted RNA molecules encapsulated within membrane vesicles modify the phenotype of target cells. Membrane vesicles, actively released by cells, represent a mechanism of intercellular communication that is conserved evolutionarily and involves the transfer of molecules able to induce epigenetic changes in recipient cells. Extracellular vesicles, which include exosomes and microvesicles, carry proteins, bioactive lipids, and nucleic acids, which are protected from enzyme degradation. These vesicles can transfer signals capable of altering cell function and/or reprogramming targeted cells. In the present review we focus on the extracellular vesicle-induced epigenetic changes in recipient cells that may lead to phenotypic and functional modifications. The relevance of these phenomena in stem cell biology and tissue repair is discussed.
Interferometric assessment of clamping quality of borehole geophones
Authors: Vaezi Yoones , Van der Baan Mirko 
Published: August 2015

Borehole arrays are often preferred over surface installations for hydraulic-fracture monitoring of deep experiments due to their proximity to the treatment zone. Borehole geophone strings are typically clamped to the observation wellbore wall using electromechanical or magnetic devices in order for them to be in close contact with the surrounding formations and record the background noise and propagating wavefields related to the microseismic experiments. This contact needs to be maintained throughout the recording time. We have used seismic interferometry to assess the clamping quality of borehole geophone arrays. We determined that the characteristics of the retrieved crosscorrelation functions between a reference receiver and other receivers in an array are indicative of the clamping quality of the former geophone to the borehole wall. We have also defined the concept of separation frequency or emergence frequency as the frequency below which direct body waves propagating along the receiver line are clearly observed on the crosscorrelation gathers. The crosscorrelation gathers associated with poorly clamped geophones show predominantly tube waves or incoherent waveforms. Body waves only emerge below very low separation frequencies. The crosscorrelation gathers of relatively better coupled geophones, on the other hand, have higher separation frequencies. We have applied this method to four different borehole microseismic data sets, labeled here as A, B, C, and D, of which data set D was previously known to suffer from some clamping issues. Data sets B and C with inferred better coupling had separation frequencies of approximately 60 Hz, whereas the other two data sets are characterized by lower separation frequencies, 15 Hz for data set A and 20 Hz for data set D, suggesting relatively poorer coupling.
Prospecting for marine gas hydrate resources
Authors: Boswell Ray , Shipp Craig , Reichel Thomas , Shelander Dianna , Saeki Tetsuo , Frye Matthew , Shedd William , Collett Timothy S. , McConnell Daniel R. 
Published: August 2015

As gas hydrate energy assessment matures worldwide, emphasis has evolved away from confirmation of the mere presence of gas hydrate to the more complex issue of prospecting for those specific accumulations that are viable resource targets. Gas hydrate exploration now integrates the unique pressure and temperature preconditions for gas hydrate occurrence with those concepts and practices that are the basis for conventional oil and gas exploration. We have aimed to assimilate the lessons learned to date in global gas hydrate exploration to outline a generalized prospecting approach as follows: (1) use existing well and geophysical data to delineate the gas hydrate stability zone (GHSZ), (2) identify and evaluate potential direct indications of hydrate occurrence through evaluation of interval of elevated acoustic velocity and/or seismic events of prospective amplitude and polarity, (3) mitigate geologic risk via regional seismic and stratigraphic facies analysis as well as seismic mapping of amplitude distribution along prospective horizons, and (4) mitigate further prospect risk through assessment of the evidence of gas presence and migration into the GHSZ. Although a wide range of occurrence types might ultimately become viable energy supply options, this approach, which has been tested in only a small number of locations worldwide, has directed prospect evaluation toward those sand-hosted, high-saturation occurrences that were presently considered to have the greatest future commercial potential.
A new record of the seagrass Halophila beccarii Ascherson from the Port Blair coast, Andaman and Nicobar Islands, India
Authors: Savurirajan M. , Lakra Raj Kiran , Ganesh Thiruchitrambalam 
Published: August 2015

Abstract
During a study of the species diversity and distribution of seagrasses from the Andaman and Nicobar Islands, Halophila beccarii was recorded for the first time. This report updates the list of seagrasses for these islands from nine to ten species. Halophila beccarii was observed in an intertidal area of muddy substratum in Haddo Bay. The occurrence of this species is significant because of its new distributional record and because it is reported as a “vulnerable species” in the IUCN Red List. The morphometric characters, biomass of the species and its habitat are described in Haddo Bay.
Prenatal diagnosis and outcomes of fetal cardiac rhabdomyomas: evaluation of seven cases
Authors: Aydin Emine , Turgal Mert , Nuhoglu Esra , Ozyuncu Ozgur 
Published: August 2015

Abstract
In this case series, we aimed to determine the outcome of prenatally diagnosed fetal cardiac rhabdomyoma. This case series is a retrospective evaluation of seven cases of fetal cardiac rhabdomyoma determined during pregnancy. Only one of these cases has been associated with tuberous sclerosis (TS). Two of the cases had just a single tumor, whereas the others were found to have multiple tumors. Termination was performed to one fetus due to hydrops fetalis. The presence of risk factors of TS in a family and multifocal or large tumors, appears to be the most important factors affecting neonatal outcomes.
Pollen Selection for Drought Tolerance in Sunflower
Authors: Totsky I. V. , Lyakh V. A. 
Published: August 2015

AbstractThe drought resistance and genetic structure of F2 sporophytic populations for some morphological marker traits after pollen selection for water stress tolerance in F1 sunflower hybrids has been studied. The emasculated inflorescences were moistened with 10% and 20% of PEG 6000 solution in the experiments and with distilled water in the control. Freshly collected pollen was used for pollination after drying up the PEG solution on stigmas. F2 resulted seeds were germinated in 20% solution of PEG 6000 for a period of 3 days, and then the percentage of seed germination was counted. Germinated and not germinated seeds were separately planted. Segregation ratios in F2 populations for leaf venation and leaf chlorophyll deficiency marker traits were analyzed at early stage of development. Pollen treatment significantly increased the drought resistance of F2 populations and changed the monogenic ratios for leaf chlorophyll deficiency marker trait.
Endoscope-integrated indocyanine green video-angiography for cerebral aneurysm surgery: a more effective technique
Authors: Sakarunchai Ittichai , Kato Yoko , Yamada Yasuhiro , Tommy Thomas 
Published: August 2015

Abstract

Introduction: Microscope-integrated indocyanine green video-angiography (mICG-VA) is used as an adjunct to aneurysm surgery in checking for small compromised perforating arteries and the remnant of an aneurysmal neck. A limitation of mICG-VA is the inability to access the deep area where small vessels are located behind the aneurysm sac or the parent artery. The endoscope-integrated ICG-VA (eICG-VA) is not only a tool in obtaining a wide angle of surgical view, but also is a technique to detect real-time blood flow during aneurysm clipping.

Methods: Patients with an unruptured cerebral aneurysm who had conventional endoscope-assisted microsurgery and eICG-VA were enrolled. We compared the efficacy and additional details of imaging from both types of procedures.

Results: The data of seven patients were reviewed. In two cases of small perforating arteries that were hidden by the aneurysm sacs, more details were detected by eICG-VA. While the performance of the conventional technique was limited, the eICG-VA revealed a wide view in the deep area during aneurysm clipping.

Conclusion: The eICG-VA provides more details of the aneurysm, especially in small perforating vessels that were hidden by the aneurysm. It can resolve the limitations of the conventional endoscope and mICG-VA.
Anti-diabetic effects of aqueous prickly lettuce (Lactuca scariola Linn.) leaves extract in alloxan-induced male diabetic rats treated with nickel (II)
Authors: Chadchan Kailash S. , Jargar Jameel G. , Das Swastika N. 
Published: August 2015

Abstract

Background: Hattaraki pallye or prickly lettuce (Lactuca scariola Linn.) is one among several green leafy plants that grow in north Karnataka; it is usually consumed by the people of this region and is found to be antidiabetic in nature. The objective of this study is to evaluate hypoglycemic activities of supplementation with aqueous extract of prickly lettuce (L. scariola) leaves in vivo in acute and subchronic exposure with or without nickel (II) along with its glucose reduction capabilities with or without nickel (II) at pH 7.0 and 9.0 in vitro.

Methods: Percentage glucose reduction (in vitro) was determined by glucose oxidase-peroxidase enzymatic method at pH 7.0 and pH 9.0 using UV-Vis spectrophotometer. Hypoglycemic activities of L. scariola were carried out in alloxan-induced male diabetic rats at both acute and subchronic exposure.

Results: The results showed a significant alteration in the λmax value of Ni (II) in combination with L. scariola leaves extracts at both pH 7.0 and 9.0. The aqueous extract also produced a significant reduction in the glucose concentration at pH 7.0 and pH 9.0 even in presence of Ni (II) in vitro. Lactuca scariola leaves in either acute or subchronic supplementation showed a greater glucose tolerance and hypoglycemic regulation of blood sugar in diabetic rats with or without nickel (II) treatments.

Conclusions:
Lactuca scariola leaves can be a substitute for synthetic drugs to treat diabetic patients.
Marked phenotypic variable expression among brothers with duplication of Xq27.1 involving theSOX3gene
Authors: Rosolowsky Elizabeth T. , Stein Robert , Marks Seth D. , Leonard Norma 
Published: August 2015

AbstractWe describe four phenotypically different brothers who share the same microduplication of Xq27.1, which contains theSOX3gene.SOX3mutations have been associated with growth hormone deficiency, variable degrees of additional pituitary hormone deficiencies, and mental retardation.SOX3also appears to play an important role in pharyngeal arch segmentation that gives rise to craniofacial structures. While these four brothers have inherited the same mutation, they manifest a spectrum of phenotypes, ranging from complete, multiple pituitary hormone deficiencies to no apparent pituitary hormone deficiency with or without craniopharyngeal/facial dysmorphisms. We look to the literature to provide putative explanations for the variable expression of the brothers’ sharedSOX3mutation.