bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lsh regulates LTR retrotransposon repression independently of Dnmt3b function
Authors: Dunican Donncha S , Cruickshanks Hazel A , Suzuki Masako , Semple Colin A , Davey Tracey , Arceci Robert J , Greally John , Adams Ian R , Meehan Richard R 
Published: December 2013

Abstract
Background
DNA methylation contributes to genomic integrity by suppressing repeat-associated transposition. In addition to the canonical DNA methyltransferases, several auxiliary chromatin factors are required to maintain DNA methylation at intergenic and satellite repeats. The interaction between Lsh, a chromatin helicase, and the de novo methyltransferase Dnmt3b facilitates deposition of DNA methylation at stem cell genes, which are hypomethylated in Lsh
−/−
embryos. We wished to determine if a similar targeting mechanism operates to maintain DNA methylation at repetitive sequences.

Results
We mapped genome-wide DNA methylation patterns in Lsh
−/−
and Dnmt3b
−/−
somatic cells. DNA methylation is predominantly lost from specific genomic repeats in Lsh
−/−
cells: LTR -retrotransposons, LINE-1 repeats and mouse satellites. RNA-seq experiments demonstrate that specific IAP LTRs and satellites, but not LINE-1 elements, are aberrantly transcribed in Lsh
−/−
cells. LTR hypomethylation in Dnmt3b
−/−
cells is moderate, whereas IAP, LINE-1 and satellite elements are hypomethylated but silent. Repressed LINE-1 elements in Lsh
−/−
cells gain H3K4me3, but H3K9me3 levels are unaltered, indicating that DNA hypomethylation alone is not permissive for their transcriptional activation. Mis-expressed IAPs and satellites lose H3K9me3 and gain H3K4me3 in Lsh
−/−
cells.

Conclusions
Our study emphasizes that regulation of repetitive elements by Lsh and DNA methylation is selective and context dependent. Silencing of repeats in somatic cells appears not to be critically dependent on Dnmt3b function. We propose a model where Lsh is specifically required at a precise developmental window to target de novo methylation to repeat sequences, which is subsequently maintained by Dnmt1 to enforce selective repeat silencing.
Sugar content in the sap of birches, hornbeams and maples in southeastern Poland
Authors: Łuczaj Łukasz , Bilek Maciej , Stawarczyk Kinga 
Published: December 2013

AbstractThere is very little data on the sugar content of tree sap in Central Europe. In order to fill this gap we measured sugar content in the spring sap of 55 trees from 8 species (six native and two introduced). Sugar content was measured chromatographically using an HPLC Dionex Ultimate 3000 system and CAD detection. The proportion of sugar was highly genus-specific: maples contained sucrose, birches a mix of glucose, fructose and sucrose and hornbeams glucose and fructose. Acer saccharinum had the sweetest sap (4.0%), followed by A. platanoides (3.2%), A. pseudoplatanus (3.2%), A. negundo (2.9%) and A. campestre (2.8%). Birches were slightly less sweet (Betula pendula 2.5% and B. pubescens 2.6%). Carpinus betulus sap contained only 0.9% sugar. The reported values for birches are higher than those reported in other European studies and the values for maples are similar to those for sugar maples in North America. As southeastern Poland has many large populations of maples and birches, a small-scale sugar syrup industry could become an additional source of income for forest owners.
The Frame-Breakers: Thomas Pynchon’s Post-human Luddites
Authors: McDonald Riley 
Published: December 2013

Abstract: Thomas Pynchon’s Vineland depicts an America moving inexorably toward what Gilles Deleuze calls a “control society,” one where intangible power structures enmesh agentless subjects. This article elaborates on the ways radical politics must be met by an equally revolutionary reconceptualization of the body. While, in Vineland, the activist film collective 24fps attempts to resist governmental power, their instrumentalization of their media technology (the film camera) leads to their own appropriation by hegemonic forces. Instead, it is the Thanatoids, liminal creatures inextricably linked with the television, who disrupt the control apparatus and present both a resistant (post)human body and a revolutionary new politics.
A sustentabilidade como ferramenta estratégica empresarial: governança corporativa e aplicação do Triple Bottom Line na Masisa
Authors: Benites Lira Luz Lazaro , Polo Edison Fernandes 
Published: December 2013

DOI: 10.5902/198346598879 The idea of ​​sustainability in a company indicates that to achieve a good economic performance, companies should adopt a strategy that includes the triple bottom line concept, according to which the companies should be accountable for their performance in the economic, environmental and social areas. This paper aims to describe the benefit to put sustainability at the heart of the corporate governance as a business strategy that will generates value from the search for better social and environmental outcomes. We mention the example of the Masisa Company to analyze the implementation of the Triple Bottom Line and Corporate Governance in both countries where it operates, Brazil and Chile.
Standardizing Retrospective Observational Research in Cutaneous Squamous Cell Carcinoma
Authors: Cheraghlou Shayan , Stevenson Mary L. , Christensen Sean R. , Bordeaux Jeremy S. , Walker Joanna L. , Srivastava Divya , Ferrándiz-Pulido Carla , Bibee Kristin P. , Carter Joi B. , Samie Faramarz H. , Patel Vishal A. , Carroll Bryan T. , Vidimos Allison T. , Baum Christian L. , Leitenberger Justin J. , Jambusaria-Pahlajani Anokhi , Ruiz Emily S. , Carucci John A. , Carr David R. , Shahwan Kathryn T. 
Published: July 2024

ImportanceCutaneous squamous cell carcinoma (CSCC) is the second most common malignant disease in the US. Although it typically carries a good prognosis, a subset of CSCCs are highly aggressive, carrying regional and distant metastatic potential. Due to its high incidence, this aggressive subset is responsible for considerable mortality, with an overall annual mortality estimated to equal or even surpass melanoma. Despite this morbidity, CSCC is excluded from national cancer registries, making it difficult to study its epidemiology and outcomes. Therefore, the bulk of the CSCC literature is composed of single-center and multi-institutional retrospective cohort analyses. Given variations in reporting measures and analyses in these studies, interpretability between studies and the ability to pool results are limited.ObjectiveTo define standardized reporting measures for retrospective CSCC studies.FindingsAn expert panel was convened to determine standardized guidelines for recording and analyzing retrospective CSCC data. A total of 13 dermatologists and dermatologic surgeons with more than 5 years of posttraining experience and considerable experience with performing CSCC outcomes research were recruited to the panel. Consensus recommendations were achieved for CSCC retrospective study reporting measures, definitions, and analyses.Conclusions and RelevanceThe recommendations in this report present the potential to standardize future CSCC retrospective studies. With such standardization, future work may have greater interstudy interpretability and allow for pooled analyses.
Area Deprivation and Disease Severity in Adult Patients With Discoid Lupus Erythematosus
Authors: Faden Daniella Forman , Xie Lillian , Stone Caroline , Lopes Almeida Gomes Lais , Le Todd , Ezeh Nnenna , Buckingham William R. , Kind Amy , Vleugels Ruth Ann , Werth Victoria P. , Arkin Lisa , Shaw Katharina S. 
Published: July 2024

ImportanceThe association of area deprivation with outcomes in discoid lupus erythematosus (DLE) remains poorly understood.ObjectiveTo determine the association between US Census block measures of deprivation and disease severity in adult patients with DLE.Design, Setting, and ParticipantsThis cross-sectional study included 154 patients with DLE seen between January 1, 2007, and January 1, 2024, at a single-center referral-based specialty rheumatologic-dermatology clinic in Philadelphia, Pennsylvania. Patients were aged 18 to 73 years and were enrolled in the University of Pennsylvania’s Cutaneous Lupus Erythematosus Database study. Data were analyzed between January 1, 2024, and May 8, 2024.ExposuresResidence in a highly disadvantaged area as geocoded by a state area deprivation index (ADI).Main Outcomes and MeasuresThe main outcome was DLE disease severity as codified by the validated Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) damage and activity scores.ResultsA total of 154 adult patients with DLE (128 women [83%] and 26 men [17%]; mean [SD] age, 43 [13] years; 6 [4%] Asian individuals, 98 [64%] Black individuals, 2 [1%] Hispanic individuals, 46 [30%] White individuals, and 2 individuals [1%] with other race or ethnicity; 78 [51%] with an ADI &amp;gt;5; 43 who currently smoked [28%];and 56 [36%] with concurrent systemic lupus erythematosus) were included in the analysis. By multivariable logistic regression, residence within communities with an ADI greater than 5 was associated with nearly 4-fold greater odds of moderate to severe damage (odds ratio [OR], 3.90; 95% CI, 1.27-12.69] and activity (OR, 3.31; 95% CI, 1.27-9.44). Concurrent cigarette smoking was similarly associated with greater odds of moderate to severe damage (OR, 3.15; 95% CI, 1.09-10.29). After controlling for ADI and other confounders, race was not significantly associated with DLE disease severity.Conclusions and RelevanceThe results of this cross-sectional study suggest that geospatial disadvantage is associated with DLE disease severity independent of race. This invites a paradigm shift that considers the social context within which racial disparities are observed, highlighting the potential for geographically targeted interventions and policy changes to improve patient outcomes in DLE.
Assessing the attractiveness of native wildflower species to bees (Hymenoptera: Anthophila) in the southeastern United States
Authors: Abbate Anthony P. , Campbell Joshua W. , Grodsky Steven M. , Williams Geoffrey R. 
Published: July 2024

Abstract

Habitat loss, agricultural intensification, pesticide use, disease and climate change have contributed to the decline of numerous insect groups. Recent government initiatives have recognized the importance of supplementary wildflower plantings to support native bee populations, yet little information exists on the attractiveness of recommended plant species to bees.

With the use of network analysis and generalized linear mixed models, we evaluated the attractiveness of 18 wildflower species belonging to 6 families (Apiaceae, Apocynaceae, Asteraceae, Fabaceae, Lamiaceae and Verbenaceae) planted in a randomized block design by conducting timed targeted sweep netting surveys. We also evaluated the floral preferences of four bee species (Apis mellifera, Halictus poeyi/ligatus, Bombus griseocollis and Bombus impatiens) to the planted wildflower species with the use of GLMs.

We found that Asclepias tuberosa, Gaillardia pulchella and Verbena hastata attracted the greatest abundance, richness and diversity of native bees compared to the other wildflower species. Collectively, Asclepias tuberosa, Gaillardia pulchella and Verbena hastata attracted 89% of all bee taxa in the study, which exemplifies the importance of including them in a wildflower mixture to attract native bees.

While several wildflower species attracted low abundance, richness and diversity of native bees such as Monarda fistulosa, Symphyotrichum pilosum and Eryngium yuccifolium, they are still ecologically important for attracting uncommon or specialist bee species and should be included in seed mixes for this reason.

Solution. Our results highlight that each species of native wildflower varies in the abundance, richness and diversity of native bees they attract; this could be considered in the decision‐making of landowners and land managers to promote wildflower plantings to reflect the needs of certain groups of bees of conservation interest.
A Biological Approach to Metalworking Based on Chitinous Colloids and Composites
Authors: Ng Shiwei , Ng Guan Zhi Benjamin , Simpson Robert E. , Fernandez Javier G. 
Published: July 2024

AbstractBiological systems evolve with minimum metabolic costs and use common components, and they represent guideposts toward a paradigm of manufacturing that is centered on minimum energy, local resources, and ecological integration. Here, a new method of metalworking that uses chitosan from the arthropod cuticle to aggregate colloidal suspensions of different metals into solid ultra‐low‐binder‐content composites is demonstrated. These composites, which can contain more than 99.5% metal, simultaneously show bonding affinity for biological components and metallic characteristics, such as electrical conductivity. This approach stands in contrast with existing metalworking methods, taking place at ambient temperature and pressure, and being driven by water exchange. Furthermore, all the nonmetallic components involved are metabolized in large amounts in every ecosystem. Under these conditions, the composites’ ability to be printed and cast into functional shapes with metallic characteristics is demonstrated. The affinity of chitometallic composites for other biological components also allows them to infuse metallic characteristics into other biomaterials. The findings and robust manufacturing examples go well beyond basic demonstrations and offer a generalizable new approach to metalworking. The potential for a paradigm shift toward biomaterials based on their unique characteristics and the principles of their manufacturing methods is highlighted.
Nitrogen‐Rich Carbon Nanodot‐Sensitized TiO2 with MWCNT Composites for Efficient Visible Light Photocatalysis
Authors: Ekanayake S. Amanda , Mai Haoxin , Mahasivam Sanje , Lu Junlin , Wen Xiaoming , Chen Dehong , Caruso Rachel A. 
Published: July 2024

AbstractTiO2‐based composite photocatalysts are currently being explored to address concerns intrinsic to TiO2, specifically high charge carrier recombination and UV light activation. Among various materials utilized for composite formation, carbon nanomaterials stand out due to their high electron conductivity, charge storage, photosensitization, and surface properties. However, high carbon content in composites has been shown to reduce performance with potential toxicity concerns. To harness the diverse properties of carbon nanomaterials in a single composite while optimizing the carbon content below 1% by weight, multi‐walled carbon nanotubes (MWCNT)/TiO2 sensitized by carbon nanodots (CND) are synthesized. The heterojunction formed between MWCNTs and TiO2 in the binary composite reduced the charge carrier recombination rate compared to TiO2. The addition of CNDs to MWCNT/TiO2 induced visible light absorbance of the resulting ternary composite, due to the forbidden electron transitions undergone in CND aggregates. CND/MWCNT/TiO2 exhibited a fivefold and 1.6‐fold increase in photocatalytic degradation of acid orange 7 and tetracycline under visible light compared to TiO2. This enhancement is attributed to the photosensitizing property of CNDs working in synergy with the charge storage ability of MWCNTs. A plausible charge transfer pathway for the activity of CND/MWCNT/TiO2 is proposed.
Targeting Transient Receptor Potential Melastatin‐2 (TRPM2) Enhances Therapeutic Efficacy of Third Generation EGFR Inhibitors against EGFR Mutant Lung Cancer
Authors: Chen Zhen , Vallega Karin A. , Boda Vijay K. , Quan Zihan , Wang Dongsheng , Fan Songqing , Wang Qiming , Ramalingam Suresh S. , Li Wei , Sun Shi‐Yong 
Published: July 2024

AbstractThere is an urgent need to fully understand the biology of third generation EGFR‐tyrosine kinase inhibitors (EGFR‐TKIs), particularly osimertinib, and to develop mechanism‐driven strategies to manage their acquired resistance. Transient receptor potential melastatin‐2 (TRPM2) functions as an important regulator of Ca2+ influx, but its role in mediating therapeutic efficacies of EGFR‐TKIs and acquired resistance to EGFR‐TKIs has been rarely studied. This study has demonstrated a previously undiscovered role of suppression of TRPM2 and subsequent inhibition of Ca2+ influx and induction of ROS and DNA damage in mediating apoptosis induction and the therapeutic efficacy of osimertinib against EGFR mutant NSCLC. The rebound elevation represents a key mechanism accounting for the emergence of acquired resistance to osimertinib and other third generation EGFR‐TKIs. Accordingly, targeting TRPM2 is a potentially promising strategy for overcoming and preventing acquired resistance to osimertinib, warranting further study in this direction including the development of cancer therapy‐optimized TRPM2 inhibitors.
Oxidation Control to Augment Interfacial Charge Transport in Te‐P3HT Hybrid Materials for High Thermoelectric Performance
Authors: Shah Syed Zulfiqar Hussain , Ding Zhenyu , Aabdin Zainul , Tjiu Weng Weei , Recatala‐Gomez Jose , Dai Haiwen , Yang Xiaoping , Maheswar Repaka Durga Venkata , Wu Gang , Hippalgaonkar Kedar , Nandhakumar Iris , Kumar Pawan 
Published: July 2024

AbstractOrganic–inorganic hybrid thermoelectric (TE) materials have attracted tremendous interest for harvesting waste heat energy. Due to their mechanical flexibility, inorganic‐organic hybrid TE materials are considered to be promising candidates for flexible energy harvesting devices. In this work, enhanced TE properties of Tellurium (Te) nanowires (NWs)‐ poly (3‐hexylthiophene‐2, 5‐diyl) (P3HT) hybrid materials are reported by improving the charge transport at interfacial layer mediated via controlled oxidation. A power factor of ≈9.8 µW (mK2)−1 is obtained at room temperature for oxidized P3HT‐TeNWs hybrid materials, which increases to ≈64.8 µW (mK2)−1 upon control of TeNWs oxidation. This value is sevenfold higher compared to P3HT‐TeNWs‐based hybrid materials reported in the literature. MD simulation reveals that oxidation‐free TeNWs demonstrate better templating for P3HT polymer compared to oxidized TeNWs. The Kang–Snyder model is used to study the charge transport in these hybrid materials. A large σE0 value is obtained which is related to better templating of P3HT on oxygen‐free TeNWs. This work provides evidence that oxidation control of TeNWs is critical for better interface‐driven charge transport, which enhances the thermoelectric properties of TeNWs‐P3HT hybrid materials. This work provides a new avenue to improve the thermoelectric properties of a new class of hybrid thermoelectric materials.
Multiscale screening of metal‐organic frameworks for one‐step ethylene purification in pressure‐swing adsorption processes
Authors: Zhou Yageng , Cao Xiang , Shang Jin , Sundmacher Kai , Zhou Teng 
Published: July 2024

AbstractPurification of polymer‐grade (99.9%) C2H4 from C2 hydrocarbon mixture is industrially important but challenging. Cryogenic distillation is energy intensive. Recently, pressure/vacuum swing adsorption (P/VSA) processes using metal‐organic frameworks (MOFs) as adsorbents have been attracting increasing attention as an alternative technology. A multiscale hierarchical framework is proposed to select promising MOFs and design suitable P/VSA processes by combining property‐based material screening and model‐based process optimization. Using this framework, we successfully identified seven promising one‐step C2H4 purification MOFs that outperformed the benchmark TJT‐100 in both C2H4 purity and recovery for the 5/90/5 C2H2/C2H4/C2H6 feed mixture. Among them, OFUCAV exhibited the highest C2H4 productivity of 0.158 mol/m3/s while JAVTAC demonstrated the lowest energy consumption of 42.76 kWh/tonne. The latter can potentially save 80% of the energy consumption compared to cryogenic distillation. Moreover, these two P/VSA processes show very high robustness in response to composition fluctuations in the feed stream.
Helix‐Sense‐Selective Memory Polymerization of Biphenylylacetylenes Bearing Carboxy and Amino Groups in Water
Authors: Okuda Shogo , Ikai Tomoyuki , Okutsu Hinako , Ando Mitsuka , Hattori Masaki , Ishidate Ryoma , Yashima Eiji 
Published: July 2024

AbstractWe report the helix‐sense‐selective memory polymerization (HSMP) of achiral biphenylylacetylenes bearing carboxy and amino pendant groups in the presence of basic and acidic chiral guests in water, respectively. The HSMP proceeds in a highly helix‐sense‐selective manner driven by noncovalent chiral ionic interactions between the monomers and guests under kinetic control, producing the one‐handed helical polymers with a static memory of helicity in one‐pot during the polymerization in a very short time, accompanied by amplification of asymmetry. The carboxy‐bound helicity‐memorized polymer self‐assembles into a cholesteric liquid crystal in concentrated water, in which a variety of basic achiral fluorophores further co‐assembles to form supramolecular helical aggregates that exhibit an induced circularly polarized luminescence in a color tunable manner.
Preparation of KH560‐UiO‐66‐NH2/Pebax mixed matrix membranes and CO2 separation
Authors: Zhao Wei , Liu Hongjing , Zhang Chengpeng , Cao Yuyang , Xu Yuying , Liu Xueli , Lu Zhen 
Published: July 2024

AbstractMetal–organic frame UiO‐66‐NH2 was modified by 3‐glycidyl ether oxypropyl trimethoxysilane (KH560), and KH560‐UiO‐66‐NH2 was synthetized and added to Pebax to prepare KH560‐UiO‐66‐NH2/Pebax mixed matrix membranes (MMMs). The epoxy group of KH560 had an amine‐epoxidation reaction with the NH2 in UiO‐66‐NH2, which prevented UiO‐66‐NH2 from agglutinating in the MMMs. In addition, the NH bond and OH bond of KH560‐UiO‐66‐NH2 could theoretically form hydrogen bonds with CO and NH bonds in the main chain of polymerization, respectively, so as to improve the interfacial compatibility between fillers and polymers. The structure and properties of the filler particles and MMMs were evaluated by Fourier transform infrared spectrometer, x‐ray diffraction, scanning electron microscopy, and thermogravimetric analyzer. The results showed that the filler particles were successfully synthesized, and had good crystallinity, uniform size distribution, and good thermal stability. The inorganic and organic interfaces of MMMs had no obvious interface defects. The obtained KH560‐UiO‐66‐NH2/Pebax MMMs showed CO2 permeability of 111.52 Barre and CO2/N2 selectivity of 92.16, which were 85.65% and 88.73% higher than that of pristine membranes, respectively. The gas separation performance of MMMs was significantly improved, exceeding the upper bound of 2008 Robeson.
Enhancing the efficacy of feminine hygiene sanitary napkins by developing a super absorbent polymer based on methyl methacrylate and methacrylic acid
Authors: Madhu Chintan , Patel Bharat 
Published: July 2024

AbstractSuper absorbent polymer based on methyl methacrylate (MMA), methacrylic acid (MAA) has been prepared during the present work for coating the top layer of feminine sanitary napkins. Synthesized polymers were coated on the needly punched cotton and adjusted as the top layer of the sanitary napkins, which has been prepared. The samples were evaluated by means of absorbency capacity, rewet back, strike through, and pH by the comparative study with commercially available sanitary napkin. The most suitable ratio of monomers (60 g MMA, and 40 g MAA) for synthesizing polymer was suggested. Absorbency capacity of the said ratio is competing with commercial sample with 63.68 g absorbent capacity. Specially, pH of prepared polymers suggested the acidic value and those are more preferable for maintaining the acidic pH of vagina at the menstrual time. Present work suggests the polymer, which can be utilize for coating the feminine napkin by the comparative result suggested by absorbency capacity, rewet back, strike through, and pH.