bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac self‐efficacy and its predictors in patients with coronary artery diseases
Authors: Kang Younhee , Yang In‐Suk 
Published: February 2013

Aims and objectivesTo investigate cardiac self‐efficacy and its predictors among patients with coronary artery diseases.BackgroundPatients with coronary artery diseases must perform the health behaviour to prevent recurrent cardiac events. It has been already well known that self‐efficacy is a vital factor in both initiating and maintaining health behaviours.DesignDescriptive correlational and cross‐sectional survey design.MethodsSubjects were interviewed using structured study questionnaires. The data collected were statistically analysed by descriptive statistics and inferential statistics including the t‐test, anova, Tukey's test, Pearson's correlation and hierarchical multiple regression analysis to determine the predictors of cardiac self‐efficacy.ResultsA convenience sample of 214 patients with coronary artery diseases was included. The mean age of subjects was 60·71 ± 10·07 years, and three‐fourths were men. The overall model significantly explained 15·8% of variance in cardiac self‐efficacy. Among predictors, occupation, diagnosis, body mass index, experience of receiving patient education and awareness of risk factors had statistically significant influences on cardiac self‐efficacy.ConclusionsRather than disease knowledge, factors related to subject's perception were more likely to associate with cardiac self‐efficacy. These findings might provide a theoretical basis to develop nursing interventions for enhancing cardiac self‐efficacy of patients with coronary artery diseases.Relevance to clinical practiceClinical nurses taking care of patients with coronary artery diseases should consider the patients' perception on their coronary artery diseases including experience of receiving patient education, and awareness of risk factors in encouraging the cardiac self‐efficacy to promote the health behaviours for the secondary prevention of coronary artery diseases.
Factors associated with quality of life after attempted suicide: a cross‐sectional study
Authors: Wang Shu‐May , Chou Yu‐Ching , Yeh Mei‐Yu , Chen Chih‐Hao , Tzeng Wen‐Chii 
Published: February 2013

Aims and objectivesTo describe factors associated with the subjective quality of life of individuals who had attempted suicide.BackgroundAlthough quality of life has been a focus of concern in mental health care, data are lacking on what life is like and what factors are related to an individual's quality of life after a suicide attempt.DesignA cross‐sectional, descriptive design was used.MethodsParticipants comprised a convenience sample of 103 individuals who had attempted suicide within the previous three months and received follow‐up care from one suicide‐prevention centre in northern Taiwan. Participants were assessed for depression and quality of life using the Beck Depression Inventory, Taiwan version and the World Health Organisation Quality of Life Instrument‐BREF, Taiwan version, respectively.ResultsAlmost half the participants (n = 49) had severe depression and one‐third of them (n = 30) reattempted suicide while receiving follow‐up care. Depression and quality‐of‐life scores were statistically significantly inversely correlated. participants' quality‐of‐life scores were most associated with their depressive level, reattempting suicide during suicidal follow‐up care, high educational level and older age.ConclusionsThe present study indicates that factors associated with quality of life decreased more in individuals with moderate/severe depression than in those with mild depression. In addition, individuals who reattempted suicide during follow‐up care were more likely to suffer from poor life quality.Relevance to clinical practiceMental health professionals should include frequent evaluation of depressive status and quality of life in follow‐up care for patients who have recently attempted suicide. Particularly, mental health professionals must treat suicidal individuals with a high tendency to reattempt suicide by establishing trust with them and allowing them to narrate their painful experiences during follow‐up care.
Severe dietary lysine restriction affects growth and body composition and hepatic gene expression for nitrogen metabolism in growing rats
Authors: Kim J. , Lee K. S. , Kwon D.‐H. , Bong J. J. , Jeong J. Y. , Nam Y. S. , Lee M. S. , Liu X. , Baik M. 
Published: February 2013

SummaryDietary lysine restriction may differentially affect body growth and lipid and nitrogen metabolism, depending on the degree of lysine restriction. This study was conducted to examine the effect of dietary lysine restriction on growth and lipid and nitrogen metabolism with two different degree of lysine restriction. Isocaloric amino acid–defined diets containing 1.4% lysine (adequate), 0.70% lysine (50% moderate lysine restriction) and 0.35% lysine (75% severe lysine restriction) were fed from the age of 52 to 77 days for 25 days in male Sprague–Dawley rats. The 75% severe lysine restriction increased (p < 0.05) food intake, but retarded (p < 0.05) growth, increased (p < 0.05) liver and muscle lipid contents and abdominal fat accumulation, increased (p < 0.05) blood urea nitrogen levels and mRNA levels of the serine‐synthesizing 3‐phosphoglycerate dehydrogenase gene, but decreased (p < 0.05) urea cycle arginase gene mRNA levels. In contrast, the 50% lysine restriction did not significantly (p > 0.05) affect body growth and lipid and nitrogen metabolism. Our results demonstrate that severe 75% lysine restriction has detrimental effects on body growth and deregulate lipid and nitrogen metabolism.
Isorhamnetin inhibits Prevotella intermedia lipopolysaccharide‐induced production of interleukin‐6 in murine macrophages via anti‐inflammatory heme oxygenase‐1 induction and inhibition of nuclear factor‐κB and signal transducer and activator of transcription 1 activation
Authors: Jin J. Y. , Choi E. Y. , Park H. R. , Choi J. I. , Choi I. S. , Kim S. J. 
Published: February 2013

Background and ObjectiveInterleukin‐6 (IL‐6) is a key proinflammatory cytokine that has been considered to be important in the pathogenesis of periodontal disease. Therefore, host‐modulatory agents directed at inhibiting IL‐6 appear to be beneficial in terms of attenuating periodontal disease progression and potentially improving disease susceptibility. In the current study, we investigated the effect of the flavonoid isorhamnetin on the production of IL‐6 in murine macrophages stimulated with lipopolysaccharide (LPS) from Prevotella intermedia, a pathogen implicated in inflammatory periodontal disease, and its mechanisms of action.Material and MethodsLipopolysaccharide from P. intermedia ATCC 25611 was isolated using the standard hot phenol–water method. Culture supernatants were collected and assayed for IL‐6. We used real‐time PCR to quantify IL‐6 and heme oxygenase‐1 (HO‐1) mRNA expression. The expression of HO‐1 protein and the levels of signaling proteins were monitored using immunoblot analyses. The DNA‐binding activity of nuclear factor‐κB (NF‐κB) was analyzed using ELISA‐based assay kits.ResultsIsorhamnetin significantly down‐regulated P. intermedia LPS‐induced production of IL‐6 as well as its mRNA expression in RAW264.7 cells. Isorhamnetin up‐regulated the expression of HO‐1 at both gene transcription and translation levels in cells stimulated with P. intermedia LPS. In addition, inhibition of HO‐1 activity by tin protoporphyrin IX blocked the inhibitory effect of isorhamnetin on IL‐6 production. Isorhamnetin failed to prevent LPS from activating either c‐Jun N‐terminal kinase or p38 pathways. Isorhamnetin did not inhibit NF‐κB transcriptional activity at the level of inhibitory κB‐α degradation. Isorhamnetin suppressed NF‐κB signaling through inhibition of nuclear translocation and DNA binding activity of NF‐κB p50 subunit and attenuated signal transducer and activator of transcription 1 signaling.ConclusionAlthough further research is required to clarify the detailed mechanism of action, we propose that isorhamnetin may contribute to blockade of the host‐destructive processes mediated by IL‐6 and could be a highly efficient modulator of the host response in the treatment of inflammatory periodontal disease. Further research in animal models of periodontitis is required to better evaluate, the potential of isorhamnetin as a novel agent for treating periodontal disease.
Antimicrobial effect of photodynamic therapy using high‐power blue light‐emitting diode and red‐dye agent on Porphyromonas gingivalis
Authors: Chui C. , Aoki A. , Takeuchi Y. , Sasaki Y. , Hiratsuka K. , Abiko Y. , Izumi Y. 
Published: February 2013

Background and ObjectiveAntimicrobial photodynamic therapy (a‐PDT) using a combination of red‐colored laser/light‐emitting diode (LED) and blue dye has been employed for periodontal therapy and the antimicrobial effect seems promising. Blue light, which has favorable wavelength properties, would be more effective as a light source for a‐PDT because blue light itself possesses an antimicrobial effect. This study aimed to investigate the effect of a‐PDT using a novel combination of high‐power blue LED and red‐dye agent on Porphyromonas gingivalis in vitro.Material and MethodsPorphyromonas gingivalis ATCC 33277 suspension was irradiated with blue LED (BL) (425–470 nm) or red LED (RL) (625–635 nm) at 30–90 J/cm2, or was mixed with erythrosine (ER), phloxine B (PB) or rose bengal (RB) with or without BL irradiation (30 J/cm2). RL (30 J/cm2) in combination with toluidine blue was employed as positive control. All the suspensions of P. gingivalis were serially diluted, plated and incubated anaerobically, and the numbers of colony‐forming units (CFUs) were counted on day 7.ResultsBL irradiation at 60 and 90 J/cm2 demonstrated a significant reduction in the numbers of CFUs. ER, PB and RB solutions at 160 μg/mL showed almost no or only a minimal reduction in the numbers of CFUs. BL at 30 J/cm2 combined with ER, PB or RB at 160 μg/mL resulted in a log reduction of 0.9, 1.0 and 7.1, respectively, in the numbers of CFUs; 30 J/cm2 BL with RB at 1.6, 16 and 160 μg/mL demonstrated a log reduction of 6.3, 8.0 and 5.5, respectively; and a log reduction of 5.2 was obtained after 30 J/cm2 RL with 16 μg/mL TB.ConclusionWithin the limits of this study, BL was found to have an antimicrobial/growth‐inhibiting effect on P. gingivalis, and a‐PDT using a combination of BL and RB shows promise as a new technical modality for bacterial elimination in periodontal therapy.
Effects of periodontal non‐surgical therapy plus azithromycin on glycemic control in patients with diabetes: a randomized clinical trial
Authors: Botero J. E. , Yepes F. L. , Ochoa S. P. , Hincapie J. P. , Roldan N. , Ospina C. A. , Castrillon C. A. , Becerra M. A. 
Published: February 2013

Background and ObjectivePeriodontitis may alter the systemic condition in patients with diabetes and hence interfere with glycemic control. The objective of this study was to determine the quantifiable changes in glycated hemoglobin (HbA1C) after periodontal non‐surgical therapy plus azithromycin in a mixed population of patients with poorly controlled diabetes.Materials and MethodsOne hundred and five patients were randomized to receive non‐surgical therapy plus azythromycin (AZ‐Sca =33), non‐surgical therapy plus placebo (PB‐Sca = 37) and supragingival prophylaxis plus azithromycin (AZ‐Pro = 35). Glycated hemoglobin, glycemia and periodontal parameters were measured at baseline, 3, 6 and 9 mo after treatment.ResultsPeriodontal parameters were improved in the AZ‐Sca and PB‐Sca groups as compared to the AZ‐Pro group. A greater reduction in probing depth was observed in the AZ‐Sca as compared to the PB‐Sca group. Improvement in clinical attachment level was similar between AZ‐Sca and PB‐Sca groups. A reduction from 8.0% to 7.2% (∆0.8%; p < 0.05) in HbA1C was observed in the AZ‐Sca at 9 mo as compared to the PB‐Sca group in which the reduction was from 7.9% to 7.6% (∆0.3%). There was no decrease in HbA1C in the AZ‐Pro group over time. Mean glycemia values decreased from 195 mg/dL to 159.2 mg/dL (∆35.8 mg/dL; p < 0.05) in the AZ‐Sca group whereas a decrease from 194 mg/dL to 174.8 mg/dL (∆19.2 mg/dL) in the PB‐Sca group at 9 mo was observed. There were no differences between the AZ‐Sca and PB‐Sca groups for glycemic parameters. No improvement in glycemic values in the AZ‐Pro group was observed.ConclusionsA modest improvement in glycemic control was detected with a trend towards the use of non‐surgical therapy plus AZ as compared to the placebo.
Changes in Sexual Functioning in Women After Neuromodulation for Voiding Dysfunction
Authors: Yih Jessica M. , Killinger Kim A. , Boura Judith A. , Peters Kenneth M. 
Published: February 2013

ABSTRACT

Introduction
Sacral neuromodulation is a well-established treatment for urinary and bowel disorders with potential use for other disorders such as sexual dysfunction.

Aim
To evaluate changes in sexual functioning in women undergoing neuromodulation for voiding symptoms.

Methods
Patients enrolled in our prospective, observational neuromodulation database study were evaluated. Data were collected from medical records, and patient-completed Female Sexual Function Index (FSFI) and Interstitial Cystitis Symptom-Problem Indices (ICSI-PI) at baseline, 3, 6, and 12 months post-implant. Patients rated overall change in sexual functioning on scaled global response assessments (GRA) at 3, 6, and 12 months post-implant. We grouped women by baseline FSFI scores: less (score &lt; 26) and more sexually functional (score ≥ 26). Data were analyzed with Pearson's Chi-square or Fisher's Exact test and repeated measures.

Main Outcomes Measures
Changes in FSFI and ICSI-PI scores in women grouped by baseline FSFI score &lt; 26 and ≥26.

Results
Of 167 women evaluated, FSFI scores improved overall from preimplant (mean 13.5 ± 8.5) to 12 months (N = 72; mean 15.9 ± 8.9, P = 0.004). At baseline and each follow-up point, ICSI-PI scores were similar between groups and improved through time. For patients in the FSFI &lt; 26 group there was improvement from baseline to 12-month scores (N = 63; 11.9 ± 6.9 to 14.8 ± 8.7; P = 0.0006). Improved FSFI domains included desire, orgasm, satisfaction, and pain. Furthermore, of the 74 subjects in this group not sexually active at baseline, 10 became sexually active during follow-up. In the FSFI ≥ 26 group there was slight but statistically significant decline in mean scores between baseline and 12 months (N = 9; 27.4 ± 1.1 to 24.5 ± 3.4; P = 0.0302); however one had become sexually inactive. A significant decrease was seen in the satisfaction domain.

Conclusions
Many factors affect sexual functioning in women; however sexual function may improve along with urinary symptoms after neuromodulation.
A Psychophysiological Investigation of Sexual Arousal in Women with Lifelong Vaginismus
Authors: Cherner Rebecca A. , Reissing Elke D. 
Published: February 2013

ABSTRACT

Introduction
Relatively little is known about the subjective reactions of women with lifelong vaginismus to erotic stimuli and genital arousal has never been investigated. Reports of maladaptive cognitions and fears regarding sexuality and intercourse suggest that anxiety may interfere with sexual arousal in women with vaginismus.

Aims
To examine the genital and subjective responses to sexually explicit film stimuli of women with lifelong vaginismus compared with women with lifelong dyspareunia and women with no pain.

Methods
Forty-five women (15 vaginismus, 15 dyspareunia, and 15 no pain) viewed two neutral and two erotic film sets, one depicting sexual activity without vaginal penetration and the other depicting intercourse, over two testing sessions.

Main Outcome Measures
Vulvar temperature was recorded using an infrared camera. Participants completed a measure of subjective responses after viewing each film.

Results
All groups experienced increased vulvar temperature during the erotic films regardless of activity depicted. In response to the erotic films, the vaginismus group reported less mental arousal than the no-pain group and a range of negative subjective responses, including threat and disgust. Overall, participants showed concordance between peak subjective sexual arousal and temperature change from baseline to peak arousal.

Conclusion
Despite negative subjective responses, women with vaginismus responded with increased genital sexual arousal to erotic films. The resilience of genital arousal may have resulted from moderate levels of anxiety experienced in the laboratory setting facilitating sexual response regardless of subjective appraisal; however, anxiety experienced in a dyadic context may interfere more substantially.
Assessment of Female Sexual Function in Pregnant Women with Gestational Diabetes Mellitus
Authors: Souza Flaviane de Oliveira , Dias Letícia Alves Rios , Franco Maíra de Menezes , Guirro Elaine Caldeira de Oliveira , Cavalli Ricardo de Carvalho , Lara Lúcia Alves da Silva , Ferreira Cristine Homsi Jorge 
Published: February 2013

ABSTRACT

Introduction
Female sexual dysfunction is a frequent problem that may be caused by several factors, such as pregnancy and diabetes, and that can affect the woman's quality of life.

Aim
The aim of this study was to assess the sexual function of pregnant women with gestational diabetes.

Methods
This is a cross-sectional clinical study involving 88 women, among which 33 were pregnant with gestational diabetes mellitus (GDM) and 55 were with low-risk pregnancy (LRP).

Main Outcome Measures
Sexual function was assessed using the Female Sexual Function Index (FSFI), a self-applicable questionnaire validated in Portuguese. All the pregnant women answered the questionnaire between the 20th and 25th week of gestation. Data were submitted to descriptive analysis by using the SAS version 9.2 procedure PROC MEANS (SAS Institute Inc., Cary, NC, USA), whereas Student's t-test was applied by using the procedure PROC TTEST (SAS Institute Inc.) at a significance level of ≤5% for all analyses.

Results
The percentage of women presenting sexual dysfunction in each group was the following: 66.7% in Group GDM and 38.9% in the Group LRP, with significant difference between the groups (P = 0.03). However, no significant differences were found between the groups regarding sexual desire, excitement, lubrication, and pain. On the total score of FSFI, Group GDM had a score ≤26.55 (P = 0.03).

Conclusion
Diabetic pregnant women were found to have a higher incidence of sexual dysfunction as their scores were lower for all FSFI domains compared with LRP females.
Sexual Dysfunction and Distress—Development of a Polish Version of the Female Sexual Distress Scale-Revised
Authors: Nowosielski Krzysztof , Wróbel Beata , Sioma-Markowska Urszula , Poręba Ryszard 
Published: February 2013

ABSTRACT

Introduction
The concept of sexually related personal distress, central to the diagnosis of all female sexual dysfunction (FSD), is currently a subject of scientific debate. Several psychometric instruments have been used to measure sexually related personal distress in women, including the Female Sexual Distress Scale (FSDS) and its revised version (FSDS-R).

Aim
To develop a Polish version of the FSDS-R (PL-FSDS-R).

Methods
In total, 210 women aged 18–55 years were included in the study. Seventy-five were diagnosed with hypoactive sexual desire disorder (HSDD), 31 were diagnosed with another FSD, and 104 were control. All subjects completed the PL-FSDS-R at baseline (day 0), day 7, and day 28. Internal consistencies were evaluated by Cronbach's α. Intraclass correlation coefficient was used to assess test–retest reliability. Discriminant validity was assessed by comparing mean scores of the FSD and control groups in a between-groups analysis of variance. Receiver operating characteristic (ROC) analysis was performed to determine optimal cutoff values of the PL-FSDS-R.

Main Outcome Measures
To measure the validity and reliability of the PL-FSDS-R and to determine optimal cutoff values.

Results
Mean total PL-FSDS-R score was statistically higher in women with HSDD and other FSD compared to healthy individuals, showing the test had discriminant validity. The frequency of sexual intercourse and quality of relationship with sexual partner but not other sexual behaviors were statistically correlated with the PL-FSDS-R score. ROC analysis confirmed these findings. All domains of the PL-FSDS-R demonstrated satisfactory internal consistencies, with a Cronbach's α-value of &gt;0.70 for the entire sample. Test–retest coefficients were between 0.86–0.92, with the best reliability for a 7-day recall period.

Conclusions
The PL-FSDS-R is a reliable questionnaire with good psychometric and discriminative validity, and can be used to measure sexually related personal distress in Polish women with FSD with a cutoff score of ≥13.
Clitoral Avulsion Successfully Repaired with 2-Octylcyanoacrylate
Authors: Berger Agatha , Worly Brett 
Published: February 2013

ABSTRACT

Introduction
Clitoral piercing is becoming more popular in the general populace, playing an aesthetic as well as likely sexual role. However, potential for injury also impacts future clitoral sexual function, thus highlighting the importance of proper repair.

Aim
To report a 29-year-old woman presented to the emergency department after a clitoral piercing injury. Examination revealed avulsion of most of the clitoral body. After the patient refused expectant and surgical management, reapproximation was performed using 2-octylcyanoacrylate.

Methods
2-Octylcyanoacrylate, commonly known as Dermabond® (Ethicon Inc., Somerville, NJ, USA), was used to reapproximate the clitoral laceration for this patient. It is a cyanoacrylate tissue adhesive, forming a strong bond between wound edges to allow for normal healing to occur below. Benefits of use are decreased time of repair, water-resistant flexible coating, and no need for suture removal.

Results
The laceration was successfully reapproximated with 2-octylcyanoacrylate. The tissue held together satisfactorily and the patient was discharged to home. She was seen as an outpatient 3 days later, with a moderately tender and swollen clitoris, but with an intact repair and improved pain. A visit 8 weeks later showed a well-healed clitoris, and the patient reported resolution of pain and return of sexual function, with successful orgasms.

Conclusions
The delicacy of clitoral anatomy and the potential impact of its injury on future sexual function make it an intimidating area of repair for the general physician. The method of repair must be tailored to the injury, patient, and physician; however, 2-octylcyanoacrylate is a viable alternative to traditional surgical or expectant management, offering strength and flexibility while avoiding further trauma with suture.