bluuebunny/crossref_metadata_2025_split huggingface dataset:
REPRODUCTIVE AGEING: BGP-15 mitigates adverse impacts of aging on sperm quality, fertility, and offspring health in male mice
Authors: Gonzalez Macarena B , Campugan Carl A , Connaughton Haley S , Andreas Eryk , Winstanley Yasmyn E , Williams Elisha J , Dorian Camilla L , Robertson Sarah A , Shoubridge Cheryl , Robker Rebecca L 
Published: August 2024

In Brief
Aging in men is associated with diminished sperm quality and a higher incidence of altered fetal development and miscarriage in resultant pregnancies. This study in mice identifies a therapeutic compound that, when administered to aged males, improves sperm quality, subsequent embryo development and post-natal offspring health.

Abstract
Aging in men is associated with diminished sperm quality and a higher incidence of altered fetal development and miscarriage in resultant pregnancies. We used a mouse model of advanced paternal age to characterize embryonic development in older male mice and tested whether pre-conception treatment with the mitochondrial activator BGP-15 improves reproductive outcomes in old males. Like older men, reproductively old male mice had higher levels of sperm DNA damage and delayed pre-implantation development, associated with a reduced fetal weight and placental weight. Analysis of neonatal outcomes of in vivo-conceived offspring found that pups sired by old males were smaller, had delayed locomotor development, and increased mortality. BGP-15 treatment for 5 days prior to conception reduced sperm DNA oxidation levels and improved on-time embryo development after IVF and pup survival. BGP-15 treatment for 3 weeks prior to conception improved on-time pre-implantation embryo development and fetal viability and increased fetal size in pregnancies sired by old males. These results validate that ageing negatively affects male fertility and offspring physiology and indicates that pre-conception treatment with BGP-15 has the potential to improve sperm quality as well as early embryo development and post-natal health.
E-commerce como estrategia comercial en micro y pequeñas empresas de calzado en El Porvenir, Perú
Authors: Coronado Salazar José Augusto 
Published: August 2024

Objetivo: Determinar la relación que existe entre la adopción y el desarrollo del comercio virtual como estrategia comercial en el sector calzado del distrito El Porvenir (región La Libertad, Perú) durante el 2020. Métodos: El enfoque de la investigación fue cuantitativa, de tipo correlacional, con diseño no experimental a través de la aplicación de una encuesta como técnica y la elaboración de un instrumento para la recolección de datos, la cual fua validada a través del alfa de Cronbach; y posteriormente aplicada a una muestra de 286 fabricantes de calzados, y con la utilización de análisis de frecuencias, tablas cruzadas, coeficiente de correlación de Spearman, y el estadístico Chi-cuadrado. Resultados: El 56 % de los encuestados coincidió en reconocer la importancia de implementar una página web que le permitiera ampliar sus canales de ventas para mejorar sus ingresos entre un 60 % y 70 %. Conclusión: Los fabricantes que implementaron el e-commerce mejoraron su penetración de mercado positivamente, obteniendo un aumento significativo sobre sus ventas e ingresos.
ПРИРОДНО-РЕСУРСНІ АКТИВИ ЯК ФАКТОР ЗАБЕЗПЕЧЕННЯ ЯКОСТІ ЖИТТЯ НАСЕЛЕННЯ ТЕРИТОРІАЛЬНИХ УТВОРЕНЬ
Authors: БИСТРЯКОВ Ігор , КЛИНОВИЙ Дмитро , КОРЖУНОВА Наталія 
Published: August 2024

Визначено поняття природно-ресурсного активу як інституціоналізовану в господарський процес і уречевлену в матеріальній та нематеріальній формах складову природного багатства, яка несе в собі мінову і споживну вартість і в результаті залучення якої суб’єктами господарювання в економічну діяльність створюється додана вартість і одержуються потоки вигод від використання природних ресурсів як товарів, засобів і факторів виробництва.
Встановлено, що будь-якому природно-ресурсному активу одночасно притаманні дві групи ознак, з яких перша є характерною для нього як для капіталу природного походження, а друга – як для активу. На цій основі запропоновано узагальнену класифікацію природно-ресурсних активів. Їх ідентифіковано як капітал, що проявляє дуалістичну вартість використання / невикористання, бере учать у реконструктивному розвитку, з одного боку, як компонент довкілля і фактор формування середовища життєдіяльності людини, а з іншого – як ресурс і фактор резильєнтного розвитку територіальних утворень. Розкрито сутнісні ознаки резильєнтності господарських систем, за якими передбачено досягнення гомеостатичної рівноваги після порушення їх нормального функціонування і вихід на траєкторію зростання, що супроводжуватиметься розширенням і підвищенням якості компетенцій, результативності територіальної економіки за участі природно-ресурсних активів.
Охарактеризовано природно-ресурсні активи як інструменти просторового розвитку, які відграють у системі суспільного виробництва одночасно три ролі – сировинно-енергетичних ресурсів, засобів і факторів розвитку виробництва і товарно-ринкових відносин, а також чинників якості життя. Ідентифіковано потенційні позитивні ефекти впливу інтеграції природно-ресурсних активів у господарський обіг на якість життя населення, у тому числі на посилення екологічної безпеки господарювання, формування привабливих умов для економічної діяльності й проживання населення, що сприятиме нормалізації демографічної ситуації в країні.
DESENVOLVIMENTO DE UM MODELO PARA ROTEIRO DE PRÁTICA LABORATORIAL PADRONIZADO:
Authors: Silva da Trindade Rayssa , De Lima Miranda Ruth , Nunes de Almeida Prado Rafael 
Published: August 2024

Este artigo propõe-se a desenvolver um modelo padronizado de roteiros de práticas laboratoriais que possa atender a práticas de diferentes cursos em áreas distintas. Inicialmente, foi aplicado à disciplina de circuitos elétricos do Curso Técnico em Eletrotécnica do IFRN, motivo seria esse curso ser ofertada em quatro diferentes Campi do Instituto. Visto que também a disciplina é difundida e presente na maioria dos cursos técnicos e superiores da área de engenharia. Nas avaliações de curso do MEC, os avaliadores veem com bons olhos quando em cada laboratório se encontram presentes ou afixadas os respectivos roteiros de práticas desses laboratórios. Visto que não estão presentes nestes espaços do campus central, surgiu a demanda de obter um modelo de experimento de laboratório para ser afixado e que deva auxiliar os docentes no planejamento pedagógico. O trabalho foi desenvolvido realizando-se uma pequena revisão bibliográfica dentre roteiros de prática, livros de práticas e materiais institucionais sobre o assunto, de modo a se fundamentar e verificar os elementos em comum e diferentes entre estes modelos. Partindo desse conhecimento o modelo de roteiro de laboratorial contém os elementos básicos obrigatórios e opcionais.
Prevalencia de consumo de sustancias psicoactivas en hombres que tienen relaciones sexuales con hombres, Colombia
Authors: Bedoya Mejia Sebastián , Cardona Arango Doris , Agudelo Cifuentes Maite Catalina , Ramos-Jaraba Sara Milena , Matagira-Rondón Giselly , Segura-Cardona Ángela M , Berbesí-Fernández Dedsy Yajaira 
Published: August 2024

Introducción: El uso de sustancias psicoactivas en la población es un problema actual, que afecta a una gran parte de la humanidad, con diversas consecuencias. Objetivo: Analizar los factores asociados al consumo de sustancias psicoactivas en hombres que tienen sexo con otros hombres (HSH) en tres ciudades de Colombia. Materiales y Métodos: Este estudio descriptivo transversal utilizó el método de muestreo respondent-driven sampling y logró una muestra de 1301 HSH. Se evaluó la asociación entre las características sociodemográficas y personales y el consumo de sustancias psicoactivas mediante la prueba chi-cuadrado. Las razones de prevalencia se calcularon con sus intervalos de confianza del 95%. En el análisis multivariado, se empleó una regresión de Poisson con enlace logarítmico y estimador robusto, para explorar los factores asociados con el uso de sustancias psicoactivas. Resultados: La prevalencia de consumo de sustancias psicoactivas en el último año fue del 87%, predominando el consumo de alcohol, marihuana y poppers. Tener parejas ocasionales (RP: 0,44; IC 95% 0,29-0,67), asistir a lugares públicos o establecimientos como bares y saunas (RP: 3,39; IC 95% 2,34 - 4,91), el trabajo sexual y no usar condón en la última relación sexual (RP: 2,10; IC 95%: 1,37 - 3,22) son factores asociados con el consumo de estas sustancias. Discusión: Se evidencia una alta prevalencia de consumo recreativo de sustancias psicoactivas, incluso superior a la encontrada en población general. Conclusión: Se confirma una alta prevalencia y asociación con conductas sexuales de riesgo, lo que requiere acciones de promoción y prevención para reducir el uso de estas sustancias.
Como citar este artículo: Bedoya Mejia Sebastián, Cardona Arango Doris, Agudelo Cifuentes Maite Catalina, Ramos-Jaraba Sara Milena, Matagira-Rondón Giselly, Segura-Cardona Ángela M, Berbesí-Fernández Dedsy Yajaira. Prevalence of psychoactive substance use in men who have sexual relationships with men, Colombia. Revista Cuidarte. 2024;15(2):e3477. https://doi.org/10.15649/cuidarte.3477
Evaluation of Tectonics along Western Extension of Gavilgarh Fault Zone, Central India using Geomorphic Indices
Authors: Paunikar S.K. , Manjare B.S. , Shrivatra J.R. 
Published: August 2024

ABSTRACT
The study examines various morphometric parameters and geomorphic indices within sub-basins along the Western extension of the Gavilgarh Fault zone. The combined analysis of these factors serves as a crucial tool for assessing tectonic activity in the region, showing strong correlations with structural discontinuities and geomorphological anomalies. The study area, located Southeast of Jalgaon, Maharashtra, demonstrates recent tectonic activity, especially in sub-basins P1 to P6. Fluvial patterns within the region reflect tectonic influences, as evidenced by various geomorphic indices. The study categorizes sub-basins into different levels of tectonic activity based on these Geomorphic indices and field observations. Additionally, slope analysis, satellite imagery, and field data reveal the presence of drainage anomalies and tectonic indicators such as V-shaped valleys, waterfalls, knick points, and more. The Relative Index of Active Tectonics further classifies subbasins according to their tectonic activity levels, shedding light on the complex interplay of geomorphic and tectonic features in the Western extension of the Gavilgarh Fault zone. Overall, this study enhances understanding of the geological processes and tectonic forces shaping the region.
Deciphering the Interplay between Reservoir Loading and Dynamic Stresses at the Pertusillo Reservoir
Authors: Barkat Adnan , Tan Yen Joe , Madson Austin 
Published: August 2024

Abstract
Our ability to comprehend the underlying mechanisms of dynamic earthquake triggering (DET) is often hindered due to a lack of concurrent static stress and pore-pressure change observations. Here, we utilize the known reservoir-induced seismicity near the Pertusillo Reservoir in southern Italy as a natural experiment to track how changes in static stress and pore pressure from hydrological operations are related to DET around the reservoir. A ∼13-month (May 2005–June 2006) high-resolution seismicity catalog is utilized to compute the DET rate for potential triggering sources. The observed DET rate of ∼16% is comparable with other tectonic and volcanic regions. However, the enhanced DET rate (∼23%) around the Pertusillo Reservoir occurs when the reservoir contains its largest seasonal load as well as during the seasonal drawdown period. This suggests that periodic stress loading and pore-pressure changes are possibly the leading mechanisms controlling DET susceptibility at the Pertusillo Reservoir. Furthermore, varying triggering rates for different earthquake clusters illustrate the dependence of DET on the spatial variation of static stress, pore pressure, and the underlying crustal heterogeneities. That said, we conclude that the DET sensitivity of the Pertusillo Reservoir is possibly influenced by reservoir loading. However, longer-term monitoring is required to further elucidate this dependence.
Modeling the Asymptotic Behavior of Higher Order Aftershocks with Deep Learning
Authors: Mizrahi Leila , Jozinović Dario 
Published: August 2024

Abstract
Aftershocks of aftershocks—and their aftershock cascades—substantially contribute to the increased seismicity rate and the associated elevated seismic hazard after the occurrence of a large earthquake. Current state-of-the-art earthquake forecasting models therefore describe earthquake occurrence using self-exciting point processes, where events can recursively trigger more events according to empirical laws. To estimate earthquake probabilities within future time horizons of interest, a large number of possible realizations of a process are simulated, which is typically associated with long computation times that increase with the desired resolution of the forecast in space, time, or magnitude range. We here propose a machine learning approach to estimate the temporal evolution of the rate of higher order aftershocks. For this, we train a deep neural network to predict the mean output of the simulation-based approach, given a parametric description of the rate of direct aftershocks. A comparison of the two approaches to estimate the mean outcome reveals that they perform very similarly in describing synthetic datasets generated with the simulation-based approach. Our method has two major benefits over the traditional approach. It is faster by several orders of magnitude, and it is not biased by ‘extreme’ realizations containing exceptionally high or low numbers of aftershocks and thus enables accurate earthquake forecasting in near-real time.
Role of genetic variations and protein expression of β-Microsemino protein in intrauterine insemination outcome of unexplained infertile men: A case-control study
Authors: Bagherian Elham , Jokari Sahar , Boroujeni Parnaz Borjian , Haratian Kaveh , Sabbaghian Marjan , Meybodi Anahita Mohseni 
Published: August 2024

Background: Intrauterine insemination (IUI) is often the first-line treatment for unexplained infertility. β-Microsemino protein (MSMB) is an abundant protein in seminal plasma that has an inhibitory effect on spontaneous acrosome reaction.
Objective: The present study aimed to evaluate MSMB gene variations and protein expression on IUI success rate in unexplained infertile men.
Materials and Methods: A case-control study was performed on 100 unexplained infertile Iranian men referred to the Royan Institute, Tehran, Iran for IUI (50 men with IUI positive result [IUI+], and 50 men with IUI negative result [IUI-]). Couples with female infertility factors (such as hormonal disorders, infrequent menstrual period, abnormality in uterus, fallopian tubes, or ovaries) and men with infections of the male accessory glands, hypogonadotropic hypogonadism, clinical varicocele, retractile testis, genital trauma, drug use, or concurrent hormonal treatment Y chromosome microdeletions, and abnormal karyotype were excluded from the study. The polymerase chain reaction sequencing was performed for the promoter and the coding regions of MSMB functional domains. To study the protein expression, the total protein of sperm was extracted, and sandwich enzyme-linked immunosorbent assay was performed.
Results: 4 variations were detected (rs12770171, rs10993994, rs2075894, and rs4517463). None of them showed significant differences between the IUI+ and IUI-groups. The mean value of protein expression did not show any differences between the groups.
Conclusion: In conclusion, there is no association between genetic variations of promoter and coding regions of MSMB functional domains as well as its expression with IUI success in unexplained infertile men.
Key words: MSMB, Beta microseminoprotein, Infertility, Male infertility.
Politique monétaire et stabilité macroéconomique dans la Communauté Économique et Monétaire de l’Afrique Centrale
Authors: Tsassa Mbouayila Franck Mondesir , Mouakassa Angèle Prudence Love 
Published: August 2024

Objectif : Cet article vise à montrer que la stabilité macroéconomique est assurée par la politique monétaire dans la communauté économique et monétaire de l'Afrique centrale.
Conception/méthodologie/approche : le cadre théorique s’inscrit dans la nouvelle école keynésienne. Empiriquement, le modèle VAR structurel est utilisé sur la période 1980-2019.
Résultats : la stabilité macroéconomique est assurée par la politique monétaire dans la plupart des pays de la CEMAC. Les chocs de demande impactent négativement le PIB au Cameroun, en RCA, au Congo, au Tchad et au Gabon. En revanche, ils impactent positivement la Guinée équatoriale. Les chocs d’offre influencent positivement la RCA, le Congo, le Tchad, le Gabon et la Guinée équatoriale ; tandis qu’au Cameroun ces ont un effet négatif. Cependant, les chocs de politique monétaire ont un impact très significatif au Cameroun, en RCA, au Gabon, en Guinée équatoriale et moins significatif au Congo et au Tchad. De leur côté, les chocs financiers influencent positivement le Congo et le Tchad ; tandis qu’au Cameroun, en RCA et au Gabon ces chocs ont une influence négative. Les chocs de liquidités ont un impact négatif au Congo et au Tchad ; mais au Cameroun, en RCA, au Gabon et en Guinée on enregistre des effets positifs. Nos résultats confirment l’importance d’une politique monétaire stricte comme instrument utile à la stabilisation de la conjoncture.
Originalité/valeur : Son originalité, par rapport à la littérature existante, se situe dans son approche méthodologique et dans la contextualisation de la théorie de la nouvelle économie keynésienne dans le cas d’une union monétaire, dont le niveau d’activité est tributaire du pétrole.
Impact of Socialization and Technical Guidance Program on Implementation of Independent Curriculum Independently
Authors: Mansur Hamsi , Sufyadi Susanti , Utama Agus Hadi 
Published: August 2024

An analysis of the impact of the socialization and technical guidance program for Implementation of Independent Curriculum Independently was conducted to encourage the operationalization of educational units, particularly teachers, to access, learn, complete, and adapt teaching materials available on Platform Merdeka Mengajar (PMM) This involves using and utilizing the results of minimum competency assessments in class to design meaningful learning. The methods employed in this community service are socialization programs/in-service training and technical guidance/in-service training for Implementation of Independent Curriculum Independently. In-service training is an activity aimed at increasing the quality of educational personnel in performing their duties as professional teachers, particularly in utilizing Information and Communication Technology (ICT) for learning, such as adapting PMM to use and utilize the results of minimum competency assessments in class to design meaningful learning. The findings of this community service program include a participant satisfaction survey, where forums for teachers such as teacher working groups have successfully emphasized teaching focused on students' learning achievements (teaching at the right level). Teachers have been able to conduct formative assessments at the beginning of the learning process to assess students' learning achievements. In conclusion, Implementation of Independent Curriculum Independently is reflected in formulating learning outcomes, becoming learning objectives, and ways to achieve these learning objectives. This is demonstrated during the community service workshop, where teachers have successfully adapted to PMM by using and utilizing the results of minimum competency assessments in class to design meaningful learning.
Estimasi sumberdaya tersisa Granit di CV Puncak Borneo, Propinsi Kalimantan Barat
Authors: Welly Welly , Meilasari Fitriani , Mukhtar Wahdaniah 
Published: August 2024

CV Puncak Borneo merupakan perusahaan yang bergerak di bidang pertambangan batu granit yang berlokasi di Desa Pandan Sembuat Kecamatan Tayan Hulu Kabupaten Sanggau, Kalimantan Barat. Dalam suatu kegiatan penambangan diperlukan perhitungan terhadap perkiraan sumberdaya tersisa yang ada pada CV Puncak Borneo agar dapat mengetahui seberapa banyak potensi sumberdaya yang ada. Perhitungan estimasi sumberdaya berperan penting dalam menentukan jumlah, kualitas, dan kemudahan dalam eksplorasi dari suatu endapan. Tujuan penelitian ini adalah memperkiraan besarnya volume dan tonase sumberdaya tersisa serta volume tanah penutup yang akan dipindahkan dari lokasi yang akan dilakukan penambangan. Perhitungan ini perlu dilakukan agar nantinya CV Puncak Borneo dapat menghitung sisa umur tambang dan dapat menghitung seberapa besar volume tanah penutup (overburden) yang harus dipindahkan dari pit penambangan. Metode yang digunakan dalam penelitian ini adalah metode penampang melintang (cross section). Pengambilan data dilakukan dengan cara memetakan area quarry rona existing menggunakan alat Total Station untuk mendapatkan data nilai X, Y dan Z yang diolah menjadi data kontur. Hasil estimasi sumberdaya tersisa pada area pit CV Puncak Borneo menggunakan Total Station adalah sebesar 470.512,8856 m3. Sementara volume tanah penutup yang menutupi batuan sebesar 255.631,2270 m3. Elevasi tertinggi pada lokasi penelitan adalah 152 mdpl sedangkan elevasi terendahnya adalah 68 mdpl.
PENERAPAN MANOVA DALAM ANALISIS HUBUNGAN ANTARA LUAS WILAYAH DENGAN CAKUPAN VAKSINASI COVID-19 DI PROVINSI KALIMANTAN SELATAN
Authors: Rasyidin Muhammad Fadhil , Anggraini Dewi , Muttaqin Hidayatullah 
Published: August 2024

In Indonesia, the problem with the spread of COVID-19 is 1.35 million with 1.17 million recovered and 36,721 deaths as of March 5, 2021. From the data on the spread of COVID-19, it can be seen from the length of time that has passed, the number of cases has increased. Sinovac (CoronaVac) is a vaccine for COVID-19 produced by the Sinovac company, using inactivated virus technology or utilizing attenuated viruses. The coverage of vaccines for dose 1 and dose 2 in South Kalimantan Province is low compared to other provinces, even though South Kalimantan Province is a province that is classified as having the smallest area among other provinces included in Kalimantan Island. The purpose of the study was to find out the relationship between area and coverage of COVID-19 vaccination in South Kalimantan Province. This study uses One-Way Manova because it analyzes one predictor variable, in the form of area and three response variables simultaneously, in the form of COVID-19 vaccination coverage based on the vaccination target category: health human resources, public officers and the elderly. The results of the study using the One-Way MANOVA method showed the Pillai's Trace value of 0.020. The results of the multivariate significance test obtained by Wilk's Lambda so that it rejects which means that the significant model or area () has an influence on vaccination coverage (). Based on alleged multivariate regression model and the results of the MANOVA test, both are directly proportional, namely there is a significant relationship that area area has an influence on COVID-19 vaccination coverage. Large areas have vaccination coverage that tends to be low when compared to small areas. Vaccination distribution for a small area can be said to be more efficient than other broad categories and for elderly vaccine recipients, it is lower than the category of vaccine recipients for public officials and health human resources