bluuebunny/crossref_metadata_2025_split huggingface dataset:
INFLUENCE OF RELIGIOUS BELIEFS ON HALAL PURCHASE INTENTION IN NON-MUSLIM CUSTOMERS
Authors: Idaman Northa , Fasa Muhammad Iqbal , Putri Siska Lusia 
Published: August 2024

This study investigates the influence of religious beliefs, perceived benefits of halal products, social influence, and attitudes towards halal products on the halal purchase intention among non-Muslim customers in Surabaya. Utilizing a quantitative research design, data were collected from 150 non-Muslim respondents through an online survey distributed via social media. The analysis was conducted using SmartPLS to evaluate the relationships between the constructs. The findings reveal that even among non-Muslim customers, strong religious beliefs can foster positive attitudes towards halal products due to shared ethical and health values. Perceived benefits, including health, ethical, and quality advantages, significantly enhance attitudes towards halal products. Social influence from family, friends, and social media positively impacts non-Muslim customers' attitudes, highlighting the role of social endorsement in shaping perceptions. Furthermore, a positive attitude towards halal products is a strong predictor of purchase intention, indicating that favorable perceptions directly translate into a higher likelihood of purchase. These findings contribute to the understanding of consumer behavior in the context of halal products and offer practical implications for businesses aiming to target non-Muslim customers. By recognizing the importance of religious beliefs, perceived benefits, and social influence, companies can develop more effective marketing strategies to promote halal products beyond the Muslim community.
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From other-representation to self-representation: exploring identity and activism in historical news media writing
Authors: Caple Helen 
Published: August 2024

This study addresses a significant gap in our understanding of self-representation in historical news media reporting. It focusses on one significant historical publication: the first nationally distributed Indigenous Australian newspaper written and edited by First Nations people – The Australian Abo Call: The Voice of the Aborigines (hereafter The AAC). The AAC was published in six editions in 1938, the year of the 150th anniversary of invasion of the continent now known as Australia. The corpus consists of all (non-fiction) articles from all six editions of this newspaper, which was founded, edited and largely written by Yorta Yorta man J.T. (Jack) Patten. As such, the study offers a synchronic ‘snapshot’ of a particular moment in Australian history. The study uses corpus-assisted discourse analysis to explore the linguistic construction of self-representation – how First Nations people write about themselves and the communities they represent. I proceed from inductively identifying group-based identity labels to categorising these labels in terms of their positionality in relation to ‘self’ and ‘other’. Using concordances, the study also qualitatively examines these identity labels through transitivity analysis. The results suggest that The AAC was a site of political awakening directed at both Indigenous and white Australians, calling on the former to mobilise, on the latter to listen, and on both to act. The analysis also shows that this activism sits very much within the dominant Western/Colonial frame, reflecting the historical settler-colonial context of the period in which this newspaper was published. The study has broader implications for corpus-assisted discourse analysis, by indicating the insights we gain by shifting our gaze away from ‘other’-representation in mainstream newspapers towards ‘self’-representation in community-led publications.
Emergence of chaotic resonance controlled by extremely weak feedback signals in neural systems
Authors: Tran Anh Tu , Nobukawa Sou , Wagatsuma Nobuhiko , Inagaki Keiichiro , Doho Hirotaka , Yamanishi Teruya , Nishimura Haruhiko 
Published: August 2024

IntroductionChaotic resonance is similar to stochastic resonance, which emerges from chaos as an internal dynamical fluctuation. In chaotic resonance, chaos-chaos intermittency (CCI), in which the chaotic orbits shift between the separated attractor regions, synchronizes with a weak input signal. Chaotic resonance exhibits higher sensitivity than stochastic resonance. However, engineering applications are difficult because adjusting the internal system parameters, especially of biological systems, to induce chaotic resonance from the outside environment is challenging. Moreover, several studies reported abnormal neural activity caused by CCI. Recently, our study proposed that the double-Gaussian-filtered reduced region of orbit (RRO) method (abbreviated as DG-RRO), using external feedback signals to generate chaotic resonance, could control CCI with a lower perturbation strength than the conventional RRO method.MethodThis study applied the DG-RRO method to a model which includes excitatory and inhibitory neuron populations in the frontal cortex as typical neural systems with CCI behavior.Results and discussionOur results reveal that DG-RRO can be applied to neural systems with extremely low perturbation but still maintain robust effectiveness compared to conventional RRO, even in noisy environments.
Predictive and concurrent validity of pain sensitivity phenotype, neuropeptidomics and neuroepigenetics in the MI-RAT osteoarthritic surgical model in rats
Authors: Otis Colombe , Cristofanilli Katrine-Ann , Frezier Marilyn , Delsart Aliénor , Martel-Pelletier Johanne , Pelletier Jean-Pierre , Beaudry Francis , Lussier Bertrand , Boyer Alexandre , Troncy Eric 
Published: August 2024

BackgroundMicro-RNAs could provide great insights about the neuropathological mechanisms associated with osteoarthritis (OA) pain processing. Using the validated Montreal Induction of Rat Arthritis Testing (MI-RAT) model, this study aimed to characterize neuroepigenetic markers susceptible to correlate with innovative pain functional phenotype and targeted neuropeptide alterations.MethodsFunctional biomechanical, somatosensory sensitization (peripheral–via tactile paw withdrawal threshold; central–via response to mechanical temporal summation), and diffuse noxious inhibitory control (via conditioned pain modulation) alterations were assessed sequentially in OA (n = 12) and Naïve (n = 12) rats. Joint structural, targeted spinal neuropeptides and differential expression of spinal cord micro-RNAs analyses were conducted at the sacrifice (day (D) 56).ResultsThe MI-RAT model caused important structural damages (reaching 35.77% of cartilage surface) compared to the Naïve group (P &lt; 0.001). This was concomitantly associated with nociceptive sensitization: ipsilateral weight shift to the contralateral hind limb (asymmetry index) from −55.61% ± 8.50% (D7) to −26.29% ± 8.50% (D35) (P &lt; 0.0001); mechanical pain hypersensitivity was present as soon as D7 and persisting until D56 (P &lt; 0.008); central sensitization was evident at D21 (P = 0.038); pain endogenous inhibitory control was distinguished with higher conditioned pain modulation rate (P &lt; 0.05) at D7, D21, and D35 as a reflect of filtrated pain perception. Somatosensory profile alterations of OA rats were translated in a persistent elevation of pro-nociceptive neuropeptides substance P and bradykinin, along with an increased expression of spinal miR-181b (P = 0.029) at D56.ConclusionThe MI-RAT OA model is associated, not only with structural lesions and static weight-bearing alterations, but also with a somatosensory profile that encompasses pain centralized sensitization, associated to active endogenous inhibitory/facilitatory controls, and corresponding neuropeptidomic and neuroepigenetic alterations. This preliminary neuroepigenetic research confirms the crucial role of pain endogenous inhibitory control in the development of OA chronic pain (not only hypersensitivity) and validates the MI-RAT model for its study.
IL-17 in plasma and bronchoalveolar lavage fluid in non-neutropenic patients with invasive pulmonary aspergillosis
Authors: He Qian , Cao Jiaqi , Zhang Ming , Feng Chunlai 
Published: August 2024

BackgroundThe purpose of this study was to investigate the diagnostic value of IL-17 detection in bronchoalveolar lavage fluid (BALF) and plasma samples from nonneutropenic patients with invasive pulmonary aspergillosis.MethodsWe retrospectively collected data on non-neutropenic patients who were suspected to have IPA admitted to the Third Affiliated Hospital of Soochow University between March 2020 to January 2023. IL-17 and GM were measured using enzyme-linked immunosorbent assays.ResultsA total of 281 patients were enrolled in this study, of which 62 had proven or probable IPA and the remaining 219 patients were controls. The plasma and BALF IL-17 levels were significantly higher in the IPA group compared with the control group. The plasma GM, plasma IL17, BALF GM, and BALF IL17 assays had sensitivities of 56.5%, 72.6%, 68.7%, and 81.2%, respectively, and specificities of 87.7%, 69.4%, 91.9%, and 72.6%, respectively. The sensitivity of IL17 in plasma and BALF was higher than that of GM. Plasma GM in combination with IL-17 increases the sensitivity but does not decrease the diagnostic specificity of GM testing. The diagnostic sensitivity and specificity of BALF GM combined with IL-17 for IPA in non-neutropenic patients were greater than 80% and there was a significant increase in sensitivity compared with BALF GM.ConclusionsPlasma and BALF IL-17 levels were significantly higher in non-neutropenic patients with IPA. The sensitivity of plasma and BLAF IL-17 for diagnosing IPA in non-neutropenic patients was superior to that of GM. Combined detection of lavage fluid GM and IL17 significantly improves the diagnosis of IPA in non-neutropenic patients. The combined detection of GM and IL-17 in plasma also contributes to the diagnosis of IPA in patients who cannot tolerate invasive procedures.
An accurate and convenient method for Mycoplasma pneumoniae via one-step LAMP-CRISPR/Cas12b detection platform
Authors: Liu Tao , Liu Qing , Chen Fuqun , Shi Ying , Maimaiti Guliya , Yang Zhanhua , Zheng Shutao , Lu Xiaomei , Li Hui , Chen Zhaoyun 
Published: August 2024

IntroductionMycoplasma pneumoniae(MP) is the major cause of respiratory infections that threaten the health of children and adolescents worldwide. Therefore, an early, simple, and accurate detection approach for MP is critical to prevent outbreaks of MP-induced community-acquired pneumonia.MethodsHere, we explored a simple and accurate method for MP identification that combines loop-mediated isothermal amplification (LAMP) with the CRISPR/Cas12b assay in a one-pot reaction.ResultsIn the current study, the whole reaction was completed within 1 h at a constant temperature of 57°C. The limit of detection of this assay was 33.7 copies per reaction. The specificity of the LAMP-CRISPR/Cas12b method was 100%, without any cross-reactivity with other pathogens. Overall, 272 clinical samples were used to evaluate the clinical performance of LAMP-CRISPR/Cas12b. Compared with the gold standard results from real-time PCR, the present method provided a sensitivity of 88.11% (126/143), specificity of 100% (129/129), and consistency of 93.75% (255/272).DiscussionTaken together, our preliminary results illustrate that the LAMP-CRISPR/Cas12b method is a simple and reliable tool for MP diagnosis that can be performed in resource-limited regions.
Serum concentrations of levosimendan and its metabolites OR-1855 and OR-1896 in cardiac surgery patients with cardiopulmonary bypass
Authors: Kipka Hannah , Liebchen Uwe , Hübner Max , Höfner Georg , Frey Otto , Wanner Klaus T. , Kilger Erich , Hagl Christian , Tomasi Roland , Mannell Hanna 
Published: August 2024

BackgroundThe inotropic drug levosimendan is often used as an individualized therapeutic approach perioperatively in cardiac surgery patients with cardiopulmonary bypass (CPB). Data regarding serum concentrations of levosimendan and its metabolites within this context is lacking.MethodsIn this retrospective descriptive proof-of-concept study, total serum concentrations (TSC) and unbound fractions (UF) of levosimendan and its metabolites OR-1896 and OR-1855 in cardiac surgery patients with CPB were measured using LC-ESI-MS/MS. Simulation of expected levosimendan TSC was performed using Pharkin 4.0. Serum NT-proBNP was assessed with ELISA.ResultsAfter levosimendan infusion (1.25 mg or 2.5 mg, respectively) after anaesthesia induction, a median TSC of 1.9 ng/ml and 10.4 ng/ml was determined in samples taken directly after surgery (T1). Median TSC of 7.6 ng/ml and 22.0 ng/ml, respectively, were simulated at T1. Whereas 1.1 ng/ml and 1.6 ng/ml TSC of OR-1896, respectively, was quantified the day after surgery (T2), TSC of the intermediate metabolite OR-1855 was mostly below the lower limit of quantification (LLOQ). The UF was 0.5% and 1.1% for levosimendan and 64.1% and 52.1% for OR-1896, respectively, with over half the samples being below LLOQ. NT-proBNP concentrations before surgery and T2 did not differ.DiscussionThe low TSC, UF and unchanged NT-proBNP levels in combination with high variation of serum levels between patients suggest a need for optimized dosing regimen of levosimendan combined with therapeutic drug monitoring for such an individualized approach. In addition, the differences between the measured and estimated concentrations may suggest a possible influence of CPB on levosimendan serum concentrations.
Relationship between adipokines and androgens in children and young adults with congenital adrenal hyperplasia
Authors: Apsan Jennifer , Lekarev Oksana , Thomas Charlene , Zhu Yuan-Shan , Cohan Kaela , Lin-Su Karen 
Published: August 2024

IntroductionChildren and young adults with congenital adrenal hyperplasia (CAH) are at increased risk of obesity and insulin resistance. There is evidence that children with CAH have increased visceral adiposity, which has been linked to metabolic syndrome and cardiovascular disease (CVD). The adipokine adiponectin has been shown to correlate with reduced metabolic risk, whereas the adipokines visfatin and leptin have been linked to visceral fat and adipocyte inflammation and can serve as biomarkers of increased metabolic risk. Few studies to date have characterized adipokine levels in children and young adults with congenital adrenal hyperplasia. We sought to investigate the relationship between adiponectin, leptin and visfatin levels to metabolic risk factors and androgen levels in children and young adults with CAH.MethodsFasting blood was obtained for visfatin, leptin, adiponectin, glucose, insulin, CRP, lipid panel, total cholesterol (TC), triglycerides (TG) and HbA1c, as well as standard laboratory tests to assess adrenal control, from children with CAH due to 21-hydroxylase deficiency. HOMA-IR was calculated based on fasting glucose and insulin. Anthropomorphic measurements of BMI and waist-to-hip ratio were also obtained.ResultsAdiponectin and androstenedione were inversely correlated (R = -0.57, p =0.016). There was a positive correlation between leptin and BMI percentile (R = 0.63, p &lt;0.001) as well as leptin and HOMA-IR (R = 0.63, p &lt;0.01). Glucocorticoid dose had a positive correlation with HOMA-IR (R=0.56, p = 0.021). Visfatin was inversely correlated with HDL cholesterol (R = -0.54, p = 0.026) and total cholesterol (R = -0.49, p &lt;0.05). Overweight children and young adults had a significantly higher leptin (p = 0.02) and HOMA-IR (p=0.001) than non-overweight children and young adults.ConclusionThe inverse relationship between adiponectin and androstenedione suggests that better CAH control can reduce the risk of insulin resistance and metabolic syndrome. However, a high glucocorticoid dose appears to increase the risk of insulin resistance, underscoring the delicate balance required when treating CAH.
Neutrophil-lymphocyte ratio predict outcome of upper gastrointestinal bleeding in emergency
Authors: Chen Xinyi , Li Xinqun , Zhao Guangju , Xu Wen 
Published: August 2024

BackgroundThe neutrophil-lymphocyte ratio (NLR) is a simple marker of systemic inflammatory responses. The present study aims to evaluate the prognostic significance of the NLR on admission day in predicting outcomes for patients with upper gastrointestinal bleeding (UGIB), which is a prevalent medical emergency.Methods726 patients who were admitted to our clinic between January 2019 and December 2022 diagnosed with UGIB, and who underwent necessary examinations, were included in the study. The patients’ Glasgow-Blatchford Score (GBS), Full Rockall Score (FRS), and NLR levels were calculated at the first admission. Outcomes were defined as in-hospital mortality, need for blood transfusion, surgical treatment and endoscopic therapy. Patients were categorized into four groups using NLR quartile levels to compare their clinical characteristics, Glasgow Blatchford Score, Full Rockall Score levels, and prognosis. Secondary, we modified FRS and GBS by adding NLR, respectively. We used area under the receiver operating characteristic curve (AUROC) to assess the accuracy of risk prediction for NLR, NLR-GBS, and NLR-FRS improved models.ResultsOf 726 patients, 6% died in hospital, 23.9% received endoscopic interventon, 4.8% received surgical treatment, and 46.4% received transfusion therapy. Multifactorial logistic regression showed that a high level of NLR was a risk factor for death in patients with UGIB (p = 0.028). NLR, GBS, FRS, NLR-GBS, and NLR-FRS have sufficient accuracy in predicting inpatient mortality, endoscopic treatment, and transfusion treatment, and the differences are statistically significant (p &lt; 0.05). In the comprehensive prediction of adverse outcomes, NLR-GBS has the highest AUROC, and in predicting inpatient mortality, NLR-FRS has the highest AUROC.ConclusionFor UGIB patients, a high NLR was strongly associated with high risk UGIB. Combined testing with the GBS and FRS can achieve good predictive results, which is valuable in guiding the pre-screening and triage of emergency nursing care and clinical treatment to ensure that patients receive rapid and effective treatment and improve the quality of care.
The contribution of granger causality analysis to our understanding of cardiovascular homeostasis: from cardiovascular and respiratory interactions to central autonomic network control
Authors: Pichot Vincent , Corbier Christophe , Chouchou Florian 
Published: August 2024

Homeostatic regulation plays a fundamental role in maintenance of multicellular life. At different scales and in different biological systems, this principle allows a better understanding of biological organization. Consequently, a growing interest in studying cause-effect relations between physiological systems has emerged, such as in the fields of cardiovascular and cardiorespiratory regulations. For this, mathematical approaches such as Granger causality (GC) were applied to the field of cardiovascular physiology in the last 20 years, overcoming the limitations of previous approaches and offering new perspectives in understanding cardiac, vascular and respiratory homeostatic interactions. In clinical practice, continuous recording of clinical data of hospitalized patients or by telemetry has opened new applicability for these approaches with potential early diagnostic and prognostic information. In this review, we describe a theoretical background of approaches based on linear GC in time and frequency domains applied to detect couplings between time series of RR intervals, blood pressure and respiration. Interestingly, these tools help in understanding the contribution of homeostatic negative feedback and the anticipatory feedforward mechanisms in homeostatic cardiovascular and cardiorespiratory controls. We also describe experimental and clinical results based on these mathematical tools, consolidating previous experimental and clinical evidence on the coupling in cardiovascular and cardiorespiratory studies. Finally, we propose perspectives allowing to complete the understanding of these interactions between cardiovascular and cardiorespiratory systems, as well as the interplay between brain and cardiac, and vascular and respiratory systems, offering a high integrative view of cardiovascular and cardiorespiratory homeostatic regulation.
NORSE/FIRES: how can we advance our understanding of this devastating condition?
Authors: Champsas Dimitrios , Zhang Xushuo , Rosch Richard , Ioannidou Evangelia , Gilmour Kimberly , Cooray Gerald , Woodhall Gavin , Pujar Suresh , Kaliakatsos Marios , Wright Sukhvir K. 
Published: August 2024

IntroductionNew onset refractory status epilepticus (NORSE) is a rare and devastating condition characterised by the sudden onset of refractory status epilepticus (RSE) without an identifiable acute or active structural, toxic, or metabolic cause in an individual without a pre-existing diagnosis of epilepsy. Febrile infection-related epilepsy syndrome (FIRES) is considered a subcategory of NORSE and presents following a febrile illness prior to seizure onset. NORSE/FIRES is associated with high morbidity and mortality in children and adults.Methods and resultsIn this review we first briefly summarise the reported clinical, paraclinical, treatment and outcome data in the literature. We then report on existing knowledge of the underlying pathophysiology in relation toin vitroandin vivopre-clinical seizure and epilepsy models of potential relevance to NORSE/FIRES.DiscussionWe highlight how pre-clinical models can enhance our understanding of FIRES/NORSE and propose future directions for research.
Effect of estradiol with or without micronized progesterone on cholinergic-related cognitive performance in postmenopausal women
Authors: Conley Alexander C. , Vega Jennifer N. , Johnson Julia V. , Dumas Julie A. , Newhouse Paul A. 
Published: August 2024

IntroductionWomen are at a higher risk of developing Alzheimer’s disease (AD), and the decline in estrogens post-menopause is thought of as a factor increasing this risk. Estradiol (E2) is important in supporting cholinergic neuronal integrity, and cholinergic functioning may be negatively impacted following the loss of E2 post-menopause. The use of exogenous E2 has been observed to enhance cholinergically mediated cognitive performance in healthy post-menopausal women, which indicates a potentially protective mechanism. However, E2 is often co-administered with progestin or progesterone to prevent endometrial proliferation. Progesterone/progestins have previously been shown to have a detrimental effect on E2-mediated biological and cognitive effects mediated by cholinergic systems in preclinical models, therefore the present study aimed to assess whether progesterone would modify the effect of E2 to influence cognition during cholinergic blockade.MethodsTwenty participants completed 3-months of oral E2 treatment with micronized progesterone (mPRO) or with placebo (PLC) in a repeated-measures within-subjects crossover design, in which they also completed five anticholinergic challenge days per hormone treatment condition. During the challenge participants were administered low or high doses of the nicotinic cholinergic antagonist mecamylamine, the muscarinic cholinergic antagonist scopolamine, or placebo. Following drug administration participants performed cognitive tests sensitive to cholinergic tone, assessing attention, episodic memory, and working memory.ResultsSignificant decrements were found on some tasks when participants were taking E2+mPRO compared to E2 alone. Specifically, under more challenging task conditions and larger anticholinergic doses, participants showed poorer performance on the Critical Flicker Fusion task and the Stroop test and responded more conservatively on the N-back working memory task. Other tasks showed no differences between treatments under cholinergic blockade.DiscussionThe findings show that mPRO when taken in concert with E2, was detrimental to effortful cognitive performance, in the presence of cholinergic blockade. These results are important for assessing the impact of combined postmenopausal hormone treatment on cognitive performance that is dependent on cholinergic functioning after menopause.