bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability of an fMRI paradigm for emotional processing in a multisite longitudinal study
Authors: Gee Dylan G. , McEwen Sarah C. , Forsyth Jennifer K. , Haut Kristen M. , Bearden Carrie E. , Addington Jean , Goodyear Bradley , Cadenhead Kristin S. , Mirzakhanian Heline , Cornblatt Barbara A. , Olvet Doreen , Mathalon Daniel H. , McGlashan Thomas H. , Perkins Diana O. , Belger Aysenil , Seidman Larry J. , Thermenos Heidi , Tsuang Ming T. , van Erp Theo G.M. , Walker Elaine F. , Hamann Stephan , Woods Scott W. , Constable Todd , Cannon Tyrone D. 
Published: March 2015

AbstractMultisite neuroimaging studies can facilitate the investigation of brain‐related changes in many contexts, including patient groups that are relatively rare in the general population. Though multisite studies have characterized the reliability of brain activation during working memory and motor functional magnetic resonance imaging tasks, emotion processing tasks, pertinent to many clinical populations, remain less explored. A traveling participants study was conducted with eight healthy volunteers scanned twice on consecutive days at each of the eight North American Longitudinal Prodrome Study sites. Tests derived from generalizability theory showed excellent reliability in the amygdala (
= 0.82), inferior frontal gyrus (IFG;
= 0.83), anterior cingulate cortex (ACC;
= 0.76), insula (
= 0.85), and fusiform gyrus (
= 0.91) for maximum activation and fair to excellent reliability in the amygdala (
= 0.44), IFG (
= 0.48), ACC (
= 0.55), insula (
= 0.42), and fusiform gyrus (
= 0.83) for mean activation across sites and test days. For the amygdala, habituation (
= 0.71) was more stable than mean activation. In a second investigation, data from 111 healthy individuals across sites were aggregated in a voxelwise, quantitative meta‐analysis. When compared with a mixed effects model controlling for site, both approaches identified robust activation in regions consistent with expected results based on prior single‐site research. Overall, regions central to emotion processing showed strong reliability in the traveling participants study and robust activation in the aggregation study. These results support the reliability of blood oxygen level‐dependent signal in emotion processing areas across different sites and scanners and may inform future efforts to increase efficiency and enhance knowledge of rare conditions in the population through multisite neuroimaging paradigms. Hum Brain Mapp 36:2558–2579, 2015. © 2015 Wiley Periodicals, Inc.
The response of a gravel‐bed river planform configuration to flow variations and bed reworking: a modelling study
Authors: Kaless Gabriel , Mao Luca , Moretto Johnny , Picco Lorenzo , Lenzi Mario A. 
Published: March 2015

AbstractA 2D depth‐averaged model has been developed for simulating water flow, sediment transport and morphological changes in gravel‐bed rivers. The model was validated with a series of laboratory experiments and then applied to the Nove reach of the Brenta River (Northern Italy) to assess its bed material transport, interpret channel response to a series of intensive flood events (R.I. ≈ 10 years) and provide a possible evolutionary scenario for the medium term. The study reach is 1400 m long with a mean slope of 0.0039 m m−1. High‐resolution digital terrain models were produced combining LiDAR data with colour bathymetry techniques. Extensive field sedimentological surveys were also conducted for surface and subsurface material. Data were uploaded in the model and the passage of two consecutive high intensity floods was simulated. The model was run under several hypotheses of sediment supply: one considering substantial equilibrium between sediment input and transport capacity, and the others reducing the sediment supply. The sediment supply was then calibrated comparing channel morphological changes as observed in the field and calculated by the model. Annual bed material transport was assessed and compared with other techniques. Low‐frequency floods (R.I. ≈ 1.5 years) are expected to produce negligible changes in the channel while high floods may erode banks rather than further incising the channel bed. Location and distribution of erosion and deposition areas within the Nove reach were predicted with acceptable biases stemming from imperfections of the model and the specified initial, boundary and forcing conditions. A medium‐term evolutionary scenario simulation underlined the different response to and impact of a consecutive sequence of floods. Copyright © 2015 John Wiley & Sons, Ltd.
Posterior trunk reconstruction with the dorsal intercostal artery perforator based flap: Clinical experience on 20 consecutive oncological cases
Authors: Brunetti Beniamino , Tenna Stefania , Aveta Achille , Poccia Igor , Segreto Francesco , Cerbone Vincenzo , Persichetti Paolo 
Published: March 2015

BackgroundFew studies in the recent literature have investigated the reliability of dorsal intercostal artery perforator (DICAP) flap in posterior trunk reconstruction. The purpose of this report is to describe our clinical experience with the use of DICAP flaps in a cohort of oncological patients.Patients and MethodsTwenty patients underwent posterior trunk reconstruction with DICAP based flaps. Patients age ranged from 45 to 76 years. All defects resulted from skin cancer ablation. Defect sizes ranged from 4 × 4 to 6 × 8 cm. The flaps were mobilized in V‐Y or propeller fashion. The flaps were islanded on 1 (12 cases), 2 (6 cases), or 3 (2 cases) perforators. Donor sites were always closed primarily.ResultsEleven V‐Y advancement flaps were performed; one of these was converted to a perforator‐plus peninsular flap design, which retained an additional source of blood supply from the opposite skin bridge. Nine flaps were mobilized in propeller fashion. Flap dimensions ranged from 4 × 6 to 6 × 14 cm. Mean operative time was 70 min. One V‐Y flap complicated with marginal necrosis that healed with no need for reintervention. All the other flaps survived uneventfully. No other complications were observed at recipient and donor sites. Follow‐up ranged from 3 months to 2 years. All the patients were satisfied with the surgical outcome.ConclusionsDICAP based flaps proved to be a reliable option to resurface posterior trunk defects following oncological resection, allowing to achieve like‐with‐like reconstruction with excellent contour and minimal donor‐site morbidity. © 2015 Wiley Periodicals, Inc. Microsurgery 36:546–551, 2016.
Evaluation of adaptive combination of 30‐channel head receive coil array data in 23Na MR imaging
Authors: Benkhedah Nadia , Hoffmann Stefan H. , Biller Armin , Nagel Armin M. 
Published: March 2015

PurposeThe aim was to optimally combine multichannel coil array data in sodium (23Na) MRI.Methods23Na MRI was conducted on a 3 Tesla MR system using a 30‐channel head receive coil array. The parameters used for the adaptive combination (ADC) reconstruction of the low signal‐to‐noise ratio (SNR) dataset have been optimized by finding the maximum mean SNR. A pseudo multiple‐replica approach has been used to obtain SNR maps of the combined images. To prove reproducibility of the combination algorithm, the procedure was repeated for several measurements.ResultsFor low SNR data, sum‐of‐squares (SOS) reconstruction leads to high background noise and a signal bias in the imaged object. The ADC reconstruction clearly reduces noise in the image and leads to an increase of the mean SNR in the range of 8% to 50%, compared to weighted SOS depending on the absolute SNR of the image. The evaluation of the effects of different noise scans showed that a small number of projections can be used to estimate noise statistics of the coil array without substantially decreasing the resulting SNR.Conclusion23Na MRI can be markedly improved by using a 30‐channel receive array and ADC reconstruction. The ADC reconstruction showed robust results for all measurements without the need for sensitivity maps. Magn Reson Med 75:527–536, 2016. © 2015 Wiley Periodicals, Inc.
The deferiprone and deferasirox combination is efficacious in iron overloaded patients with β‐thalassemia major: A prospective, single center, open‐label study
Authors: Totadri Sidharth , Bansal Deepak , Bhatia Prateek , Attri Savita V. , Trehan Amita , Marwaha R. K. 
Published: March 2015

BackgroundThe high cost, coupled with the need for continuous infusion, renders Desferrioxamine (DFO), a non‐feasible option for iron‐chelation in a large majority of patients with β‐thalassemia major in developing countries. Monotherapy with deferiprone (DFP) or deferasirox (DFX) may not always attain optimal control, particularly in heavily iron‐loaded patients. Combination of DFP and DFX is a potential alternative.ProcedureA prospective, single‐center, open‐label, uncontrolled study was conducted to evaluate the safety and efficacy of the combination in patients with β‐thalassemia major. Patients who had received either DFP or DFX for >1 year and a serum ferritin >2,000 μg/L were enrolled. Blood counts, liver/renal functions, and serum ferritin were monitored during the 1‐year study period. Facilities for cardiac T2*‐MRI were unavailable.ResultsThirty‐six patients with a mean age of 13 ± 6.9 years (range: 4–29) and a ferritin of 6,768 ± 4,145 μg/L formed the study cohort. Eight (22%) patients had transient gastrointestinal adverse effects. DFX was discontinued in one patient for persistent abdominal pain/diarrhea. Eight (22%) had joint symptoms; DFP was discontinued in two. Four (11%) patients had elevation in AST/ALT levels, managed with temporary interruption of DFX. Nine (25%) had an inconsistent elevation of creatinine to >33% of baseline; no intervention was done. One had transient proteinuria. None had neutropenia. At the end of 1 year, the serum ferritin reduced by a mean value of 3,275.3 ± 618.2 μg/L (P < 0.001).ConclusionsThe oral combination was found to be safe, efficacious, and a feasible option in patients with suboptimal response to monotherapy. Pediatr Blood Cancer 2015;62:1592–1596. © 2015 Wiley Periodicals, Inc.
Functional dye as a comonomer in a water‐soluble polymer
Authors: Zhang Wenwen , Vinueza Nelson R. , Datta Preeta , Michielsen Stephen 
Published: March 2015

ABSTRACTIn many applications, a functional additive is blended into a polymer matrix to enhance its properties. However, when the polymer and functional additive are applied to a surface, the functional molecule may be easily lost. In favorable cases, it may be possible to incorporate the additive directly into the polymer as a comonomer. In this study, a functionalized polymer has been obtained through the combination of linking a photodynamic, antimicrobial dye, Rose Bengal, to vinyl benzyl chloride via etherification and then polymerizing this into a water‐soluble polymer using chain growth copolymerization. Characterization of the efficiency of synthesis, solubility of the final product, and singlet oxygen production rate has been performed. Dialysis was used to determine the extent of incorporation of the dye into the polymer. The chemical structure of the intermediate produced through etherification has been verified. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 1594–1599
Synthesis and characterization of novel fluorosilicone rubber using imide modified vinyl‐containing fluorosilicone resin as cross‐linker
Authors: Xu Tao , Liu He , Song Jie , Shang Shibin , Song Zhanqian , Zou Kaifei , Yang Chong 
Published: March 2015

ABSTRACTA novel imide modified vinyl‐containing fluorosilicone resin (MP‐VFS) was firstly prepared from maleopimaric acid (MPA), and characterized by1H NMR and13C NMR. Containing MPA based imide heterocycle (MPABI), MP‐VFS was further used as a novel cross‐linker to prepare MPA modified fluorosilicone rubber (MP‐FSR). Morphology, mechanical and oil‐resistance properties, thermal properties, and low temperature resistance of MP‐FSR had been studied. Microphase separation was observed in MP‐FSR. Although the tensile strength of fluorosilicone rubber was not significantly enhanced, the tearing strength, breaking elongation, rebound resilience and hardness were effectively improved. When the MP‐VFS content was 2.0 wt %, the tearing strength of MP‐FSR was increased by 23.5%, breaking elongation by 18.6% and rebound resilience by 9.7%. The thermal stability was enhanced due to the incorporation of MPABI. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem.2015,53, 1769–1776
Synthesis and characterization of polyphenylenes with polypeptide and poly(ethylene glycol) side chains
Authors: Akbulut Huseyin , Endo Takeshi , Yamada Shuhei , Yagci Yusuf 
Published: March 2015

ABSTRACTWe report a novel approach for fabrication of multifunctional conjugated polymers, namely poly(p‐phenylene)s (PPPs) possessing polypeptide (poly‐l‐lysine, PLL) and hydrophilic poly(ethylene glycol) (PEG) side chains. The approach is comprised of the combination of Suzuki coupling and in situ N‐carboxyanhydride (NCA) ring‐opening polymerization (ROP) processes. First, polypeptide macromonomer was prepared by ROP of the corresponding NCA precursor using (2,5‐dibromophenyl)methanamine as an initiator. Suzuki coupling reaction of the obtained polypeptide and PEG macromonomers both having dibromobenzene end functionality using 1,4‐benzenediboronic acid as the coupling partner in the presence of palladium catalyst gave the desired polymer. A different sequence of the same procedure was also employed to yield polymer with essentially identical structure. In the reverse sequence mode, low molar mass monomer (2,5‐dibromophenyl)methanamine, and PEG macromonomer were coupled with 1,4‐benzenediboronic acid in a similar way followed by ROP of the L‐Lysine NCA precursor through the primary amino groups of the resulting polyphenylene. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 1785–1793
Aerodynamically shaped vortex generators
Authors: Hansen M. O. L. , Velte C. M. , Øye S. , Hansen R. , Sørensen N. N. , Madsen J. , Mikkelsen R. 
Published: March 2015

AbstractAn aerodynamically shaped vortex generator has been proposed, manufactured and tested in a wind tunnel. The effect on the overall performance when applied on a thick airfoil is an increased lift to drag ratio compared with standard vortex generators. Copyright © 2015 John Wiley & Sons, Ltd.
Risk Factors for Re‐recurrence After First Reoperative Surgery for Locoregional Recurrent/Persistent Papillary Thyroid Carcinoma
Authors: Lee Hwan Seo , Roh Jong‐Lyel , Gong Gyungyup , Cho Kyung‐Ja , Choi Seung‐Ho , Nam Soon Yuhl , Kim Sang Yoon 
Published: March 2015

AbstractBackgroundPapillary thyroid carcinoma (PTC) is generally an indolent tumor indicative of favorable prognosis. However, post‐treatment recurrences may be problematic, and management strategies for recurrent disease have not been established. This study investigated risk factors associated with re‐recurrence of PTC after reoperative surgery.Materials and methodsThis study included 151 patients with pathologically confirmed recurrent/persistent PTC who underwent reoperation. Clinical factors, operative and pathologic findings, serum thyroglobulin levels, postoperative complications, and recurrences were examined. Univariate and multivariate analyses were performed to identify factors associated with re‐recurrence‐free survival (RFS) after reoperative surgery.ResultsRecurrent tumors were found in thyroid remnants or previous resection bed (n = 28), central nodes (n = 48), and lateral neck nodes (n = 102). Biochemical complete remission (stimulated thyroglobulin <1 ng/mL) was achieved in 69 (51.5 %) patients after reoperative surgery. Permanent vocal fold paralysis and hypoparathyroidism developed in 6 (4.1 %) and 4 (2.8 %) patients, respectively. Vocal fold paralysis occurred primarily due to intentional nerve resection following tumor invasion. During a median follow‐up of 57.5 months, 41 (27.2 %) patients had re‐recurrences. Univariate analyses showed that extranodal extension (p = 0.028), recurrent laryngeal nerve invasion (p = 0.037), as well as stimulated (p = 0.001) and unstimulated (p = 0.015) serum thyroglobulin were significant predictors of RFS. Multivariate analyses showed that postoperative biochemical remission independently predicted RFS (p = 0.014).ConclusionsPostoperative thyroglobulin after reoperative surgery predicted re‐recurrence. Careful follow‐up of these patients after reoperation is recommended.
Plant Sterol Diversity in Pollen from Angiosperms
Authors: Villette Claire , Berna Anne , Compagnon Vincent , Schaller Hubert 
Published: March 2015

AbstractHere we have examined the composition of free sterols and steryl esters of pollen from selected angiosperm species, as a first step towards a comprehensive analysis of sterol biogenesis in the male gametophyte. We detected four major sterol structural groups: cycloartenol derivatives bearing a 9β,19‐cyclopropyl group, sterols with a double bond at C‐7(8), sterols with a double bond at C‐5(6), and stanols. All these groups were unequally distributed among species. However, the distribution of sterols as free sterols or as steryl esters in pollen grains indicated that free sterols were mostly Δ5‐sterols and that steryl esters were predominantly 9β,19‐cyclopropyl sterols. In order to link the sterol composition of a pollen grain at anthesis with the requirement for membrane lipid constituents of the pollen tube, we germinated pollen grains from Nicotiana tabacum, a model plant in reproductive biology. In the presence of radiolabelled mevalonic acid and in a time course series of measurements, we showed that cycloeucalenol was identified as the major neosynthesized sterol. Furthermore, the inhibition of cycloeucalenol neosynthesis by squalestatin was in full agreement with a de novo biogenesis and an apparent truncated pathway in the pollen tube.
Proteomic Analysis Reveals PGAM1 Altering cis‐9, trans‐11 Conjugated Linoleic Acid Synthesis in Bovine Mammary Gland
Authors: Wang T. , Lee S. B. , Hwang J. H. , Lim J. N. , Jung U. S. , Kim M. J. , Kang H. S. , Choi S. H. , Lee J. S. , Roh S. G. , Lee H. G. 
Published: March 2015

Abstractcis‐9, trans‐11 Conjugated linoleic acid (CLA) is one of the most extensively studied CLA isomers due to its multiple isomer‐specific effects. However, the molecular mechanisms of cis‐9,trans‐11 CLA synthesis in ruminant mammary gland are still not clearly understood. This process may be mediated, to a certain extent, by trans‐11 C18:1 regulated by stearoyl‐CoA desaturase‐1 (SCD1) and/or its syntrophic proteins. This study aimed to investigate the effects of TVA on SCD1‐mediated cis‐9,trans‐11 CLA synthesis in MAC‐T cells and its potential molecular mechanism. Results showed that trans‐11 C18:1 was continually taken up and converted into cis‐9,trans‐11 CLA in MAC‐T cells during the 4‐h incubation of 50 μM trans‐11 C18:1. SCD1 protein expression increased more than twofold at 2 h (P < 0.01) and 2.5 h (P < 0.05) before decreasing to less than half of the normal level at 4 h (P < 0.05). One up‐regulated (RAS guanyl releasing protein 4 isoform 1 [RASGRP4]) and six down‐regulated proteins (glucosamine‐6‐phosphate deaminase 1 [GNPDA1], triosephosphate isomerase [TPI1], phosphoglycerate mutase 1 [PGAM1], heat shock protein beta‐1 [HSPB1], annexin A3 [ANXA3], thiopurine S‐methyltransferase [TPMT]) were found in MAC‐T cells treated with trans‐11 C18:1. Of these seven identified proteins, the presence of GNPDA1 and PGAM1 was verified in several models. More trans‐11 C18:1 was taken up after PGAM1 knockdown by small interfering RNA (siRNA). In conclusion, our data suggested that PGAM1 may have a negative relationship with SCD1 and seemed to be involved in cis‐9, trans‐11 CLA synthesis by facilitating the absorption of trans‐11 C18:1 in the bovine mammary gland.
Impact of Aromatization by Citrus limetta and Citrus sinensis Peels on Olive Oil Quality, Chemical Composition and Heat Stability
Authors: Khemakhem Ibtihel , Yaiche Chiraz , Ayadi Mohamed Ali , Bouaziz Mohamed 
Published: March 2015

AbstractThe objectives of this work were to study the impact of aromatization by sweet lemon and sweet orange peels on olive oil quality, chemical composition and heat stability. Flavored olive oils were prepared by maceration of sweet lime and sweet orange zests at 1, 3 and 5 %. The oil samples were kept at 60 °C for 40 days. Physicochemical tests (FFA, PV, oxidative stability, polyphenols and pigments contents) were carried out. The antioxidant activity (β‐carotene‐linoleate bleaching assay, DPPH radical scavenging and reducing power) was also tested. Results indicated that the addition of citrus zests contributed to the increase in polyphenols and carotenoids contents. Moreover, it led to an increase in the DPPH‐radical scavenging activity (99.50 % for flavored olive oil with sweet orange zests at 5 %). Flavored olive oils with sweet orange zests were more stable to heat treatment than those flavored with sweet lemon zests. The degradation rate of bioactive compounds was lower for virgin olive oil comparing to flavored oils.
Tuning the translational freedom of DNA for high speed AFM
Authors: Lee Andrew J. , Szymonik Michal , Hobbs Jamie K. , Wälti Christoph 
Published: March 2015

Abstract
Direct observation is arguably the preferred way to investigate the interactions between two molecular complexes. With the development of high speed atomic force microscopy (AFM), it is becoming possible to observe directly DNA-protein interactions with relevant spatial and temporal resolutions. These interactions are of central importance to biology, bionanotechnology, and functional biologically inspired materials. As in all microscopy studies, sample preparation plays a central role in AFM observation and minimal perturbation of the sample is desired. Here, we demonstrate the ability to tune the interactions between DNA molecules and the surface to create an association strong enough to enable high-resolution AFM imaging while also providing sufficient translational freedom to allow the relevant protein-DNA interactions to take place. Furthermore, we describe a quantitative method for measuring DNA mobility, while also determining the individual forces contributing to DNA movement. We found that for a weak surface association, a significant contribution to the movement arises from the interaction of the AFM tip with the DNA. In combination, these methods enable the tuning of the surface translational freedom of DNA molecules to allow the direct study of a wide range of nucleo-protein interactions by high speed atomic force microscopy.
Back on the streets: Maturation and risk factors for recidivism among serious juvenile offenders
Authors: Leverso John , Bielby William , Hoelter Lynette F. 
Published: March 2015

ABSTRACTThis study examines how social and cognitive factors shape future criminal activity among serious juvenile offenders and assesses how adolescents' cognitive development affects the relative impact of those factors over time. The sample, from the Pathways to Desistance Study, is comprised of youth (aged 14–18 years) in the United States convicted of serious criminal offenses, and the outcome measure is self‐reported crime. We rely on data collected when the youth were first interviewed (n = 1088) and 18–24 months later (n = 904). Logistic regression analyses reveal a strong relationship between impulsiveness and criminal behavior, regardless of age. Susceptibility to peer pressure and perceived risk that friends would be arrested were found to predict future criminal activity among younger adolescents, but have little impact at later ages. External factors such as amount of social support and gang membership have varying effects over time.