bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial DNA Interactions of the Binuclear Threading Intercalator Λ,Λ‐[μ‐bidppz(bipy)4Ru2]4+: An NMR Study with [d(CGCGAATTCGCG)]2
Authors: Wu Lisha , Reymer Anna , Persson Cecilia , Kazimierczuk Krzysztof , Brown Tom , Lincoln Per , Nordén Bengt , Billeter Martin 
Published: March 2013

AbstractBinuclear polypyridine ruthenium compounds have been shown to slowly intercalate into DNA, following a fast initial binding on the DNA surface. For these compounds, intercalation requires threading of a bulky substituent, containing one RuII, through the DNA base‐pair stack, and the accompanying DNA duplex distortions are much more severe than with intercalation of mononuclear compounds. Structural understanding of the process of intercalation may greatly gain from a characterisation of the initial interactions between binuclear RuII compounds and DNA. We report a structural NMR study on the binuclear RuII intercalator Λ,Λ‐B (Λ,Λ‐[μ‐bidppz(bipy)4Ru2]4+; bidppz=11,11′‐bis(dipyrido[3,2‐a:2′,3′‐c]phenazinyl, bipy = 2,2′‐bipyridine) mixed with the palindromic DNA [d(CGCGAATTCGCG)]2. Threading of Λ,Λ‐B depends on the presence and length of AT stretches in the DNA. Therefore, the latter was selected to promote initial binding, but due to the short stretch of AT base pairs, final intercalation is prevented. Structural calculations provide a model for the interaction: Λ,Λ‐B is trapped in a well‐defined surface‐bound state consisting of an eccentric minor‐groove binding. Most of the interaction enthalpy originates from electrostatic and van der Waals contacts, whereas intermolecular hydrogen bonds may help to define a unique position of Λ,Λ‐B. Molecular dynamics simulations show that this minor‐groove binding mode is stable on a nanosecond scale. To the best of our knowledge, this is the first structural study by NMR spectroscopy on a binuclear Ru compound bound to DNA. In the calculated structure, one of the positively charged Ru2+ moieties is near the central AATT region; this is favourable in view of potential intercalation as observed by optical methods for DNA with longer AT stretches. Circular dichroism (CD) spectroscopy suggests that a similar binding geometry is formed in mixtures of Λ,Λ‐B with natural calf thymus DNA. The present minor‐groove binding mode is proposed to represent the initial surface interactions of binuclear RuII compounds prior to intercalation into AT‐rich DNA.
Enantioselective Total Synthesis of (+)‐Ophiobolin A
Authors: Tsuna Kazuhiro , Noguchi Naoyoshi , Nakada Masahisa 
Published: March 2013

AbstractThe enantioselective total synthesis of (+)‐ophiobolin A is described. This total synthesis features the construction of the spiro CD ring of (+)‐ophiobolin A through a stereoselective intramolecular Hosomi–Sakurai cyclization reaction, the joining of the A ring to the CD ring by using a reaction reported by Utimoto, and the construction of the ophiobolin eight‐membered carbocyclic ring through ring‐closing metathesis (RCM), which was performed for the first time in this study. This successful RCM reaction required the use of a substrate that contained either a benzyloxy or a methoxymethoxy group at the C5 position and either an isopropenyl group or its hydroxylated form at the C6 position.
ChemInform Abstract: The Crystal and Electronic Structures of the Li2‐xAg1+xIn3 (x = 0.05) Indide.
Authors: Chumak Ihor , Pavlyuk Volodymyr , Dmytriv Grygoriy , Pauly Hermann , Ehrenberg Helmut 
Published: March 2013

AbstractLi1.95Ag1.05In3 is prepared from the elements (Ta crucible, 1100 °C for 15 min followed by annealing at 150 °C for 1 month) and characterized by single crystal XRD and TB‐LMTO‐ASA computations.
ChemInform Abstract: Physical Properties of Double Perovskite‐Type Barium Neodymium Osmate Ba2NdOsO6.
Authors: Wakeshima Makoto , Hinatsu Yukio , Ohoyama Kenji 
Published: March 2013

AbstractThe title compound is synthesized from stoichiometric mixtures of BaO2, Os, and Nd2O3 (Pt crucible, Ag2O as oxygen donor in a second Pt crucible, 1270 K, 6 h).
ChemInform Abstract: Structure and Optical Properties of a Noncentrosymmetric Borate RbSr4(BO3)3.
Authors: Xia M. J. , Li R. K. 
Published: March 2013

AbstractSingle crystals of the new title compound are prepared by reaction of Rb2CO3, SrCO3, and H3BO3 using RbF as a fluxing agent (Pt crucible, 1020 °C, 24 h).
ChemInform Abstract: Synthesis and Crystal Structure of Mg0.5NbO2: An Ion‐Exchange Reaction with Mg2+ Between Trigonal [NbO2]‐ Layers.
Authors: Miura Akira , Takei Takahiro , Kumada Nobuhiro 
Published: March 2013

AbstractThe title compound is synthesized from LiNbO2 through a cation exchange reaction with MgCl2 using a KCl/MgCl2 flux (graphite crucible, 450—550 °C, 1—5 h).
ChemInform Abstract: Determination of a New Structure Type in the Sc—Fe—Ge—Sn System.
Authors: Brgoch Jakoah , Ran Sheng , Thimmaiah Srinivasa , Canfield Paul C. , Miller Gordon J. 
Published: March 2013

AbstractSc4Fe5Ge6.10Sn1.47 is identified as a product of the reaction of Sc, Fe, and Ge in a Sn flux.
ChemInform Abstract: Anodic Generation of a Zirconium Catalyst for Ferrier Rearrangement and Hetero Michael Addition.
Authors: Stevanovic Dragana , Pejovic Anka , Damljanovic Ivan , Vukicevic Mirjana , Bogdanovic Goran A. , Vukicevic Rastko D. 
Published: March 2013

AbstractEletrolysis with a Zr anode generates a soluble zirconium species which promotes the Ferrier rearrangement of peracylated glucal (I) in the presence of nucleophiles and the hetero Michael addition of nucleophiles to enone (VII)
ChemInform Abstract: Enantioselective Rhodium‐Catalyzed Nucleophilic Allylation of Cyclic Imines with Allylboron Reagents.
Authors: Luo Yunfei , Hepburn Hamish B. , Chotsaeng Nawasit , Lam Hon Wai 
Published: March 2013

AbstractThe title reaction represents the first rhodium‐catalyzed enantioselective nucleophilic allylation of π‐electrophiles with allylboron compounds.
ChemInform Abstract: Regioselective Addition Reactions of 3‐Phenylsulfonyl‐2‐trifluoromethyl‐1,3‐butadiene with Nucleophiles.
Authors: Yang Eun Joon , Jeon Sung Lan , Jeong In Howa 
Published: March 2013

AbstractThe regioselective addition of various nucleophiles to title compound (I) is studied.
ChemInform Abstract: Selective Reduction of Ketones Using Water as a Hydrogen Source under High Hydrostatic Pressure.
Authors: Tomin Anna , Lazarev Alexander , Bere Metthew P. , Redjeb Hana , Toeroek Bela 
Published: March 2013

AbstractAcyclic, cyclic, and aryl ketones are transformed to their corresponding secondary alcohols without the use of any base.
ChemInform Abstract: CHBr3/TiCl4/Mg as an Unusual Nucleophilic CBr2 Carbenoid. Effective and Chemoselective Dibromomethylenation of Aldehydes and Ketones.
Authors: Bhorge Yeshwant Ramchandra , Chang Cheng‐Ta , Chang Su‐Haur , Yan Tu‐Hsin 
Published: March 2013

AbstractThe method can be applied to enolizable and sterically hindered ketones.
ChemInform Abstract: Umpolung of Fluoroform by C—F Bond Activation: Direct Difluoromethylation of Lithium Enolates.
Authors: Iida Toshiaki , Hashimoto Ryota , Aikawa Kohsuke , Ito Shigekazu , Mikami Koichi 
Published: March 2013

AbstractThe method allows the creation of difluoromethyl‐functionalized all‐carbon quaternary centers in various types of compounds.
ChemInform Abstract: Practical Method for the Cu‐Mediated Trifluoromethylation of Arylboronic Acids with CF3 Radicals Derived from NaSO2CF3 and tert‐Butyl Hydroperoxide (TBHP).
Authors: Ye Yingda , Kuenzi Stefan A. , Sanford Melanie S. 
Published: March 2013

AbstractVarious important (hetero)aromatic structural motifs are available under mild conditions.
ChemInform Abstract: NaOH‐Catalyzed Imine Synthesis: Aerobic Oxidative Coupling of Alcohols and Amines.
Authors: Donthiri Ramachandra Reddy , Patil Rajendra D. , Adimurthy Subbarayappa 
Published: March 2013

AbstractA wide range of imines is synthesized by the present oxidative coupling of alcohols and amines which is catalyzed by NaOH under aerobic conditions.
ChemInform Abstract: One‐Pot Synthesis of Amides from Aldehydes and Amines via C—H Bond Activation.
Authors: Cadoni Roberta , Porcheddu Andrea , Giacomelli Giampaolo , De Luca Lidia 
Published: March 2013

AbstractAliphatic and aromatic aldehydes and a series of mono‐or disubstituted amines can be used for the process.
ChemInform Abstract: Synthesis of the 3,4,5‐Trimethoxy‐2‐(3,4‐methylenedioxy‐6‐nitrophenyl)benzaldehyde for Divergent Preparation of Cytotoxic Biaryls.
Authors: Labruere Raphael , Helissey Philippe , Desbene‐Finck Stephanie , Giorgi‐Renault Sylviane 
Published: March 2013

AbstractAn optimized procedure is elaborated for the preparation of the target compound (II) from the known aldehyde precursor (I).
ChemInform Abstract: Palladium Catalyzed Direct α‐Arylation of α,α‐Difluoroketones with Aryl Bromides.
Authors: Guo Chen , Wang Ruo‐Wen , Qing Feng‐Ling 
Published: March 2013

AbstractA straightforward and efficient access to a variety of α‐aryl‐α,α‐difluoroketones (III) is described.
ChemInform Abstract: Two‐Step One‐Pot Synthesis of Benzoannulated Spiroacetals by Suzuki—Miyaura Coupling/Acid‐Catalyzed Spiroacetalization.
Authors: Butkevich Alexey N. , Corbu Andrei , Meerpoel Lieven , Stansfield Ian , Angibaud Patrick , Bonnet Pascal , Cossy Janine 
Published: March 2013

AbstractTosylate and chloride as leaving group of the benzyl alcohol prevent a reaction under conditions A), but they are tolerated as substituents at the aromatic ring [cf.(IIIc) and (IIIf)].
ChemInform Abstract: Synthesis of 2‐Phenyl‐4,5,6,7‐tetrahydro‐1H‐indoles with a Chiral Substituent at the Nitrogen Atom
Authors: Andreev I. A. , Ryzhkov I. O. , Kurkin A. V. , Yurovskaya M. A. 
Published: March 2013

Abstractbased on the opening of epoxide (I) with chiral amines or amino acids and subsequent Pd‐catalyzed intramolecular cyclization
ChemInform Abstract: Highly Enantioselective Fluorination of Unprotected 3‐Substituted Oxindoles: One‐Step Synthesis of BMS 204352 (MaxiPost).
Authors: Li Jun , Cai Yunfei , Chen Weiliang , Liu Xiaohua , Lin Lili , Feng Xiaoming 
Published: March 2013

AbstractIn the presence of Sc(OTf)3 and the chiral N‐oxides (NDO) and (LIG) a number of unprotected 3‐substituted oxindoles undergoes efficient fluorination to afford 3‐fluorooxindole derivatives with high enantioselectivty.
ChemInform Abstract: Lanthanide Amides [(Me3Si)2N] 3Ln(μ‐Cl)Li(THF)3‐Catalyzed Phospho‐Aldol‐Brook Rearrangement Reaction of Dialkyl Phosphites with Isatins.
Authors: Wang Lu , Yao Zhigang , Xu Fan , Shen Qi 
Published: March 2013

AbstractThe lanthanum complex is the most efficient catalyst in the process.
ChemInform Abstract: Enantioselective Cyclopropanation of Indoles: Construction of all‐Carbon Quaternary Stereocenters.
Authors: Oezueduru Guelsuem , Schubach Thea , Boysen Mike M. K. 
Published: March 2013

AbstractIndole substrates bearing an N‐acetyl group are transformed to almost diastereomerically pure exo‐products (III).
ChemInform Abstract: A Greener, Facile and Scalable Synthesis of Indole Derivatives in Water: Reactions of Indole‐2,3‐diones with 1,2‐Difunctionalized Benzene.
Authors: Jain Renuka , Sharma Kanti , Kumar Deepak 
Published: March 2013

AbstractDiones (I) are treated with amino substrates (II), (IV) or (VI) to form the different heterocyclic systems shown.
ChemInform Abstract: Rapid Access of 2,3,4‐Trisubstituted‐2,3,4,9‐tetrahydrothiopyrano[2,3‐b]indole Derivatives via One‐Pot Three‐Component Reaction Using Organocatalysis.
Authors: Singh Shivendra , Srivastava Anvita , Samanta Sampak 
Published: March 2013

AbstractThe aromatic nucleophilic thiolation/tandem thio‐Michael—Henry reaction in the presence of DABCO affords the desired scaffold without any significant diastereoselectivity, except in the case of the branched nitrostyrene (IIa).
ChemInform Abstract: Highly Efficient Solvent‐Free Synthesis of Pyranopyrazoles by a Broensted‐Acidic Ionic Liquid as a Green and Reusable Catalyst.
Authors: Ebrahimi Javad , Mohammadi Ali , Pakjoo Vahid , Bahramzade Ehsan , Habibi Amir 
Published: March 2013

AbstractBiologically active substituted dihydropyrano[2,3‐c]pyrazole derivatives (IV) are obtained by a simple, green, and efficient four‐component reaction of various benzaldehydes (II), ethyl acetoacetate (I), malononitrile (III), and hydrazine hydrate using an acidic ionic liquid as catalyst.
ChemInform Abstract: Synthesis of Flavones and γ‐Benzopyranones Using Mild Sonogashira Coupling and 18‐Crown‐6 Ether Mediated 6‐endo Cyclization.
Authors: Chuang Da‐Wei , El‐Shazly Mohamed , Balaji D. Barve , Chung Yu‐Ming , Chang Fang‐Rong , Wu Yang‐Chang 
Published: March 2013

AbstractA facile, mild, and selective method for the synthesis of benzopyran derivatives is reported.
ChemInform Abstract: NbCl5‐Promoted Synthesis of 4‐Aryl‐3,4‐dihydrocoumarins by Multicomponent Reaction.
Authors: dos Santos Willian Henrique , da Silva‐Filho Luiz Carlos 
Published: March 2013

AbstractA novel diastereoselective synthesis of the title coumarins (IV) is achieved by NbCl5‐promoted three component reaction of 3,5‐dimethoxyphenol, dimethyl malonate, and aromatic aldehydes.
ChemInform Abstract: 1,3‐Dibromo‐5,5‐dimethylhydantoin (DBH)/Kaolin: An Efficient Reagent System for the Synthesis of 14‐Aryl‐14H‐dibenzo[a,j]xanthenes under Solvent‐Free Conditions.
Authors: Shirini Farhad , Khaligh Nader Ghaffari , Imanzadeh Gholam Hossein , Ghasem‐Abadi Parisa Ghods 
Published: March 2013

AbstractThe reaction of 2‐naphthol with aromatic aldehydes is catalyzed by DBH in the presence of kaolin as an additive to give dibenzoxanthene derivatives in high yields.
ChemInform Abstract: Efficient Generation of Pyridines by Ruthenium Carbene Mediated [2 + 2 + 2] Cyclotrimerization.
Authors: Medina Sandra , Dominguez Gema , Perez‐Castells Javier 
Published: March 2013

AbstractA broad spectrum of fused pyridine systems is available starting from diynes and nitriles.
ChemInform Abstract: Regiocontrolled SNAr and Palladium Cross‐Coupling Reactions of 2,4,7‐Trichloropyrido[3,2‐d]pyrimidine.
Authors: Tikad Abdellatif , Akssira Mohamed , Massip Stephane , Leger Jean‐Michel , Jarry Christian , Guillaumet Gerald , Routier Sylvain 
Published: March 2013

AbstractTrichloropyrido[3,2‐d]pyrimidine (I) undergoes arylation and amination reactions selectively at C2, C4 and C7 positions.
ChemInform Abstract: Synthesis of Imidazo[4,5‐b]pyridines with a Chiral Substituent at the Nitrogen Atom and Their Conversion to Piperazine Derivatives.
Authors: Bukhryakov K. V. , Kurkin A. V. , Yurovskaya M. A. 
Published: March 2013

AbstractA variety of imidazopyridine derivatives bearing a chiral substituent at the N1‐imidazole nitrogen are synthesized [cf.
ChemInform Abstract: Synthesis of Novel 2‐(4‐(2‐Morpholinoethoxy)phenyl)‐N‐phenylacetamide Analogues and Their Antimicrobial Study.
Authors: Jayadevappa H. P. , Nagendrappa G. , Umesh S. , Chandrashekar S. 
Published: March 2013

AbstractThe title compounds (V) are obtained starting from hydroxyphenylacetic acid (I) and screened for their activity against a variety of fungal and bacterial strains in comparison to clotrimazole and streptomycin.
ChemInform Abstract: Borylation of Organo Halides and Triflates Using Tetrakis(dimethylamino)diboron.
Authors: Bello Charles S. , Schmidt‐Leithoff Joachim 
Published: March 2013

AbstractIn situ borylation of various halides and triflates renders possible the approach to boronic ester structures for subsequent Suzuki couplings.
ChemInform Abstract: A Facile and Expedient One‐Pot Three‐Component Reaction Leading to Multifunctionalized Stabilized Phosphorus Ylides.
Authors: Hassani Zahra , Esfandiarpour Zeinab 
Published: March 2013

AbstractPhosphorus ylides (IV) are obtained by a simple and effective one‐pot three‐component reaction of NH‐acids (I), triphenylphosphine (II), and acetylenic esters (III) under mild and neutral reaction conditions.
ChemInform Abstract: Synthesis of Benzo[c]phenanthridine Alkaloids by Pd(OAc)2‐Induced Direct Aromatic Carbonylation.
Authors: Kumazawa Eri , Tokuhashi Takashi , Horibata Akiyoshi , Kurono Nobuhito , Senboku Hisanori , Tokuda Masao , Ohkuma Takashi , Orito Kazuhiko 
Published: March 2013

AbstractBenzo[c]phenanthridine alkaloids like oxysanguinarine (IV) and O‐methyloxyfagaronine (Vb) are synthesized by a Pd(OAc)2‐induced direct aromatic carbonylation reaction and subsequent dehydrogenation with DDQ.
ChemInform Abstract: Development of an Alkaloid—Pyrone Annulation: Synthesis of Pleiomaltinine (XIII).
Authors: Ziegler Robert E. , Tan Shin‐Jowl , Kam Toh‐Seok , Porco John A. Jr. 
Published: March 2013

AbstractAnnulation of carbazoles and related heterocycles with 3‐siloxy‐4‐pyrones provides unusual alkaloid‐pyrone structures.
ChemInform Abstract: Total Synthesis and Biological Evaluation of Auripyrones A and B.
Authors: Hayakawa Ichiro , Takemura Takuma , Fukasawa Emi , Ebihara Yuta , Sato Natsuki , Nakamura Takayasu , Suenaga Kiyotake , Kigoshi Hideo 
Published: March 2013

AbstractThe total synthesis of auripyrone A (Ia) and B (Ib) is presented and their cytotoxicities against a panel of 39 human cancer cell lines is investigated.
Comparative Binding Energy (COMBINE) Analysis for Understanding the Binding Determinants of Type II Dehydroquinase Inhibitors
Authors: Peón Antonio , Coderch Claire , Gago Federico , González‐Bello Concepción 
Published: March 2013

AbstractHerein we report comparative binding energy (COMBINE) analyses to derive quantitative structure–activity relationship (QSAR) models that help rationalize the determinants of binding affinity for inhibitors of type II dehydroquinase (DHQ2), the third enzyme of the shikimic acid pathway. Independent COMBINE models were derived for Helicobacter pylori and Mycobacterium tuberculosis DHQ2, which is an essential enzyme in both these pathogenic bacteria that has no counterpart in human cells. These studies quantify the importance of the hydrogen bonding interactions between the ligands and the water molecule involved in the DHQ2 reaction mechanism. They also highlight important differences in the ligand interactions with the interface pocket close to the active site that could provide guides for future inhibitor design.
The Pharmacokinetic Profile of the Combination of Naproxen and Tizanidine in Rat
Authors: Patiño‐Camacho Selene Isabel , Moreno María Guadalupe Lozoya , Flores‐Murrieta Francisco Javier , Déciga‐Campos Myrna 
Published: February 2013

Abstract

Preclinical Research

Naproxen is an anti‐inflammatory drug used in a variety of anti‐inflammatory syndromes. There is evidence showing that tizanidine enhances the anti‐inflammatory effect in rats. This study examines the pharmacokinetics of naproxen when it is combined with tizanidine. Combining these two drugs is an attractive modality for inflammation complaints. Oral coadministration of naproxen/tizanidine produced a synergistic anti‐inflammatory effect in rats. The swelling of the rat paw was measured by a plethysmometer using carrageenan as an inflammatory agent. In this study, rats received oral doses of naproxen (1, 3, and 4.2 mg/kg), and these doses were combined with a fixed dose of tizanidine (0.01 mg/kg). To evaluate the pharmacokinetic interaction between naproxen/tizanidine, blood samples were obtained at selected times in the 24 h after oral administration and were analyzed using a validated high‐performance liquid chromatography method. Systemic administration of naproxen alone or in combination with tizanidine produced a dose‐dependent anti‐inflammatory effect. In the pharmacokinetic interaction study, no statistically significant difference was observed for the naproxen concentration‐time profiles in the presence of tizanidine. The experimental findings suggest that systemic tizanidine is able to increase the naproxen‐induced anti‐inflammatory effect in rats. This effect was not due to a modification of the bioavailability of naproxen.
Conjugation‐Driven Cascade Approach to Enantiopure Pyrano‐Fused 1,5‐Benzodiazepines by Tandem Condensation/[3,3]‐Sigmatropic Rearrangement/Aza‐Michael Addition–Elimination
Authors: Husain Irfan , Saquib Mohammad , Shaw Arun K. 
Published: March 2013

AbstractSugar‐based Morita–Baylis–Hillman (MBH) acetates easily obtained from commercially available D‐glucal underwent rapid reaction with 1,2‐benzenediamines to give, in good yields, a series of enantiomerically pure tricyclic pyrano‐fused 1,5‐benzodiazepines with multiple points of diversity, which could serve as potential drug scaffolds. The driving force behind this reaction seemed to be the high stability associated with the conjugated tricyclic system. The reaction involved an unprecedented amine–carbonyl condensation/[3,3]‐sigmatropic rearrangement/cyclization cascade.
Binding Mechanisms and Driving Forces for the Selective Complexation between Pillar[5]arenes and Neutral Nitrogen Heterocyclic Compounds
Authors: Han Kang , Zhang Yanyan , Li Jian , Yu Yihua , Jia Xueshun , Li Chunju 
Published: March 2013

AbstractTo clarify the binding mechanisms and driving forces for the unique ability of pillar[5]arenes to recognize neutral molecules, the complexation of a series of nitrogen heterocycle substituted 1,4‐butylene guests with pillar[5]arenes was studied. Guests molecules that have similar structures exhibit remarkably different association constants, and multiple weak C–H···N interactions between the alkyl groups of the pillar[5]arenes and the outer nitrogen atoms of the heterocycles of the guests are the dominant driving forces for complexation.
Controls of subsurface temperature variability in a western boundary upwelling system
Authors: Belem Andre L. , Castelao Renato M. , Albuquerque Ana Luiza 
Published: February 2013

AbstractThe mechanisms controlling subsurface temperature variability on the outer shelf in a western boundary upwelling system are quantified using observations from a mooring deployed off Cabo Frio, Brazil. Results from a multiple linear regression analysis reveal that, in addition to low‐frequency variations associated with the seasonal evolution of temperature, the dominant mechanisms controlling temperature variability are wind stress curl–driven upwelling, cross‐isobath transport, the proximity of the Brazil Current to the shelf break, and perhaps changes in the strength of tidal mixing associated with the spring‐neap cycle. The influence of the proximity of the Brazil Current decreases strongly with depth, being restricted to the top 80 m. Regression coefficients indicate that the relative contributions from the different forcings are roughly similar and that no single process has a dominant role explaining temperature variability near the shelf break. These suggest that successful modeling efforts in the region must adequately represent each of those processes.
Cholestasis in a patient with gallstones and a normal gamma-glutamyl transferase
Authors: Moghadamrad Sheida , Montani Matteo , Weimann Rosemarie , De Gottardi Andrea 
Published: February 2013

Abstract

Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies in the gene

ABCB11

, which encodes the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter. Here we report the case of a patient presenting with features of benign recurrent intrahepatic cholestasis associated with a heterozygous mutation in the

ABCB11

gene. Immunohistochemistry showed a gradual decrease of BSEP from zone 1 to zone 3 of the liver lobule, suggesting that the mutation identified here may predispose patients to cholestasis through a delocalization process of BSEP at the lobular level.