bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between a New Rigid Dilatometer and the Ménard Pressuremeter in a Reconstituted Sand
Authors: Besson Théo , Jacquard Catherine , Rispal Michel , Reiffsteck Philippe , Szymkiewicz Fabien 
Published: July 2024

Abstract
Borehole expansion tests such as the Ménard pressuremeter test (PMT) are widely used in geotechnical testing as they provide a modulus that can be used to estimate settlements under geotechnical structures. This paper describes a new soil investigation apparatus that performs an expansion test in a prebored hole called the dilatometer Fondasol test (DFT). From this test, an in situ load-displacement curve is obtained in the same manner as the PMT. The apparatus is based on the concept of the rigid dilatometer used in rock mechanics with two rigid and semicylindrical shells spread against the borehole walls. Four different prototypes have been developed and successfully tested on Hostun sand reconstituted by vibration in a test chamber at a density index varying from 0.18 to 0.72. Results show that despite the significant differences in the shells’ geometry, they have little impact on the measurement of an apparent modulus. Three different formulas derived from elastic theory have been evaluated for the computation of dilatometer moduli: EDFT;M, EDFT;G, and EDFT;BJ. A comparative study with pressuremeter tests shows that EDFT;M and EDFT;BJ are close to the pressuremeter moduli EPMT;M with a ratio EPMT/EDFT ranging between 1.2 and 0.8 depending on the density of the sand. The moduli EDFT;G are significantly higher than EPMT;M and vary importantly depending on the prototypes. Dilatometer’s load-displacement curves show that global failure occurs at higher stresses than with the pressuremeter.
Expression levels of the selenium-uptake receptor LRP8, the antioxidant selenoprotein GPX1 and steroidogenic enzymes correlate in granulosa cells
Authors: Hummitzsch Katja , Kelly Jasmine E , Hatzirodos Nicholas , Bonner Wendy M , Tang Feng , Harris Hugh H , Rodgers Raymond J 
Published: July 2024

Graphical abstract

Abstract
Reactive oxygen species (ROS) are a by-product of the activity of cytochrome P450 steroidogenic enzymes. Antioxidant enzymes protect against ROS damage. To identify if any particular antioxidant enzyme is used to protect against ROS produced by granulosa cells as follicles enlarge and produce oestradiol, we measured in the bovine granulosa cells the expression of two steroidogenic enzymes (CYP11A1, CYP19A1), important for progesterone and oestradiol production. We also measured the expression of the members (FDXR, FDX1, POR) of their electron transport chains (ETC). We measured antioxidant enzymes (GPXs 1–8, CAT, SODs 1 and 2, PRDXs 1–6, GSR, TXN, TXNRDs 1–3). Since selenium is an active component of GPXs, the selenium-uptake receptors (LRPs 2 and 8) were measured. Only the selenium-dependent GPX1 showed the same increase in expression as the steroidogenic enzymes did with increasing follicle size. GPX4 and PRDX2/6 decreased with follicle size, whereas SOD1/2, CAT, GSR, and TXNRD3 were lowest at the intermediate sizes. The other antioxidant enzymes were unchanged or expressed at low levels. The expression of the selenium-uptake receptor LRP8 also increased significantly with follicle size. Correlation analysis revealed statistically significant and strongly positive correlations of the steroidogenic enzymes and their ETCs with both GPX1 and LRP8. These results demonstrate a relationship between the expression of genes involved in steroidogenesis and selenium-containing antioxidant defence mechanisms. They suggest that during the late stages of folliculogenesis, granulosa cells are dependent on sufficient expression of GPX1 and the selenium transporter LRP8 to counteract increasing ROS levels caused by the production of steroid hormones.

Lay summary
In the ovary, eggs are housed in follicles which contain the cells that produce oestrogen in the days leading up to ovulation of the egg. Oestrogen is produced by the action of enzymes. However, some of these enzymes also produce by-products called reactive oxygen species (ROS). These are harmful to eggs. Fortunately, cells have protective antioxidant enzymes that can neutralise ROS. This study was interested in which particular antioxidant enzyme(s) might be involved in neutralising the ROS in follicle cells. It was found that only one antioxidant enzyme, GPX1, appeared to be co-regulated with the enzymes that produce oestrogen and progesterone in the follicular cells. GPX1 contains the essential mineral selenium. In summary, this study has identified which antioxidant appears to be involved in neutralising ROS in the days leading to ovulation. It highlights the importance of selenium in the diet.
The gallows in Holíč (Skalica district, Slovakia) archaeological research and virtual reconstruction
Authors: Bešina Daniel , Bönde Gogová Stanislava , Šteiner Pavol 
Published: July 2024

AbstractThe archaeological research of the gallows in Holíč is one of the first purposefully surveyed sites of this kind in Slovakia. The issue of research on execution sites is only marginally dealt with in our territory. The research confirmed the presence of a simple brick gallows with two supporting posts. Skeletal remains of human bodies discovered in the excavated area are no less important in this context. The information and the finds can contribute to the study of capital execution and types of gallows not only in the territory of today's Slovakia, but also in the wider area of the historical Kingdom of Hungary. The features datable to the Second World War are also worth mentioning and provide an ideal opportunity to compare archaeological finds of modern military history with the available written sources.
Rufus Estes: Good Things to Eat As Suggested by Rufus
Authors: Jaine Tom 
Published: July 2024

Rufus Estes: Good Things to Eat As Suggested by Rufus: Howling at the Moon Press, Jenks, Oklahoma, 1999: ISBN 0-9654333-1-5:142 pp., b/w photos, p/b, $19.95.
Echo-loop of subclinical cardiovascular toxicity in women associated with HER2-positive breast cancer therapy
Authors: Pershukov I. V. , Akbalaeva B. A. , Shulzhenko L. V. , Batyraliev T. A. , Gurovich O. V. , Vinogradskaia V. V. , Karben Z. A. , Fettser D. V. , Kuznetsova T. N. , Ivanenkova E. Yu. , Raiimbek uulu N. , Kvasova M. V. , Kalmatov R. K. , Imetova Ja. B. , Mamatova S. M. , Jainakbayev N. T. , Seidalin A. O. , Rakhalskaya N. N. 
Published: July 2024

Aim. To assess the incidence and timing of subclinical cardiac dysfunction associated with therapy for HER2-positive locally advanced or metastatic breast cancer, and to analyze the difference in time from significant reduction in left ventricular (LV) global longitudinal strain (GLS) to significant reduction in LV ejection fraction (LVEF) (cardiotoxicity "echo-loop").Material and methods. A total of 187 women 58±11 years without baseline cardiac dysfunction with verified HER2-positive locally advanced or metastatic breast cancer who received sequential adjuvant therapy with doxorubicin+cyclophosphamide, docetaxel+trastuzumab and trastuzumab monotherapy were followed up in 4 centers in four countries within 12 months with regular (every 3 weeks) speckle-tracking echocardiographic monitoring.Results. Subclinical cardiac dysfunction associated with breast cancer therapy (CTRCD) appears in each block of therapy after the first course. Its frequency increases significantly after each subsequent course compared to the previous one. By the end of the 4th course in each block of therapy, subclinical CTRCD is noted from 24,6% (almost every 4th patient in the chemotherapy block) to 32,6-33,7% (almost every 3rd patient in the chemotherapy and targeted therapy blocks). In 24 out of 25 cases of severe subclinical CTRCD (96%) with a fall in LVEF <40%, a decrease in LV GLS >15% was preceded. The time difference from a decrease in LV GLS to a decrease in LVEF <40% (cardiotoxicity "echo loop”) ranges from 5 to 16 weeks depending on the cancer therapy option.Conclusion. Until recently, the period of identified moderate subclini­cal cardiac dysfunction was not used to prescribe therapy for the pre­vention and treatment of cardiotoxicity. Enhanced speckle-tracking echo­cardiographic monitoring may reduce the incidence of severe sub­clinical and overt clinical cardiac dysfunction. Guidelines for car­diotoxicity monitoring should be reviewed to reduce the incidence of se­vere cardiac complications of cancer therapy.
Changes of carbohydrate metabolism and insulin resistance parameters at different compliance levels in young people
Authors: Sineglazova A. V. , Fakhrutdinova A. Sh. 
Published: July 2024

Aim. To analyze early disorders of carbohydrate metabolism and insulin resistance (IR) at different compliance levels in young people.Material and methods. Ninety-four patients (45 men/49 women; median (Me)=33 [28,7-38] years) were examined. This prospective observational study used data of the questionnaire of the quantitative assessment of the adherence to treatment (QAA-25), fasting plas­ma glucose levels, oral glucose tolerance test, levels of glycated hemo­globin (HbA1c), insulin and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Statistical processing was carried out in IBM SPSS Statistics 26.Results. Only 15,8% had high adherence to medical support, 8,9% — lifestyle modification (LM) and general compliance, 10,9% — drug therapy. The means for most types of adherences were in the low range. In the low and medium LM groups, over 18 months the number of patients with elevated HbA1c levels increased from 7,1 to 18,8% (p=0,021) and IR from 12% to 31,8% (p=0,000). In patients with low overall LM compared to high ones, the probability of HbA1c increase raised by 5,5 times, and hyperinsulinemia by 1,16 times.Conclusion. In an 18-month prospective study, young adults with low compliance levels showed an increase in the incidence of hyper­insulinemia, IR, and prediabetes.
Penerapan strategi index card match pada bahasan bangun datar untuk meningkatkan minat belajar matematika siswa
Authors: Yudiana Ayu Ninda , Kurniawati Naning , Ilmiyah Nurul 
Published: July 2024

Pembelajaran matematika selama ini masih kurang bervariasi sehingga minat belajar matematika sangat rendah sehingga berdampak pada hasil belajar siswa. Hal ini terlihat dari hasil observasi minat belajar matematika siswa di kelas VII B SMP Islam Darussalam Kedungrejo yang masih tergolong rendah, sehingga diperlukan strategi pembelajaran untuk menarik minat siswa yaitu dengan strategi Index Card Match. Tujuan penelitian ini adalah untuk mengetahui bagaimana penerapan strategi Index Card Match pada pembahasan bangun datar dalam meningkatkan minat belajar matematika. Peneliti menggunakan metode deskriptif kualitatif. Strategi pembelajaran aktif (Index card math) merupakan strategi yang menekankan pada peran aktif siswa di dalam kelas. Strategi ini diharapkan mampu membangun kemandirian siswa dalam proses pembelajaran. Penelitian ini dilakukan di SMP Islam Darussalam Dungmas Kedungrejo Sumberejo Bojonegoro kelas VII yang berjumlah 21 siswa. Pengumpulan data dilakukan dengan wawancara, observasi, dan dokumentasi. Hasil pengumpulan data menunjukkan bahwa setiap siswa memiliki minat belajar matematika yang rendah. Namun, setelah penerapan strategi Index Card Match berdasarkan tes hasil belajar sebanyak 21 siswa, ketuntasan belajar klasikal sebesar 80,9 persen; terbukti Implementasi Pembelajaran dengan strategi Index Card Match pada pembelajaran Bentuk Datar memberikan pengaruh yang besar terhadap minat belajar siswa. Sedangkan pada hasil kuesioner diketahui rata-rata persentase seluruh aspek yang diamati adalah 93 persen memberikan respon positif dan 7 persen memberikan respon negatif. Hal ini dapat menunjukkan bahwa lebih dari 75 persen siswa memberikan respon positif terhadap Pembelajaran dengan Strategi Index Card Match.
Exploring student’s mathematical argument in solving modeling solid with curved surface problem
Authors: Ihsani Ulynnuha Aulia , Ekawati Rooselyna , Shodikin Ali 
Published: July 2024

This study aims to describe the mathematical argument of students in modeling mathematical problems with curved side shapes according to the classification of high and low initial mathematical abilities. This study used the descriptive method with the qualitative approach. Six ninth-grade students from junior high school in Surabaya were given five initial mathematics ability test questions. From the results of the initial mathematics ability test, two subjects were selected with the highest and lowest scores. Data instruments in this study use modeling solid with curved surface problem tests and interviews. The collected data were analyzed based on elements of mathematical argument, that is, claims, evidence, reasoning, and rebuttal. The result shows that subjects with high initial ability can make accurate claims, provide appropriate evidence and reason, and provide evidence to reject the counterclaim. This subject is categorized in level 2 of mathematical argumentation. While the subject with low initial ability cannot make claims accurately, the evidence and reason are unsuitable to support the claim and do not provide evidence and reasons to reject the counterclaim. This subject is categorized in level 1 of mathematical argumentation.
Screening of vegetable pea breeding material on rust resistance at Omsk State Agrarian University
Authors: Kuzmina S. P. , Kazydub N. G. , Plotnikova L. Y. , Kukoleva M. Yu. 
Published: July 2024

Relevance. Pea rust regularly damages the vegetable pea crop in the Omsk region. The harmfulness of the disease has begun to intensify in recent years; in years favorable for the development of the disease, the damage to susceptible varieties can be 100%. Therefore, breeders are forced to constantly search for new sources of resistance genes due to the rapidly developing rust pathogens. The goal of our research is to screen samples of a vegetable pea collection under field conditions in the southern forest-steppe of Western Siberia and identify sources of resistance.Material and Methodology. As an object for study, 72 samples of vegetable peas were taken from the Federal State Budgetary Scientific Institution Federal Scientific Vegetable Center (FSBSI FSVC) and the “Federal Research Center of the All-Russian Institute of Plant Genetic Resources named after. N.I. Vavilov" (VIR). The research was conducted over four years from 2020 to 2023. in the conditions of the southern forest-steppe of the Omsk region. The records were carried out in accordance with the “Methodological instructions for studying the collection of grain legumes”.Results and Discussion. As a result of the studies, it was established that the resistance of vegetable peas to rust depends on both the genotype and weather conditions. Weather conditions had the greatest influence on the development of the disease (the factor’s share was 51.5%), the contribution of the genotype was also significant and amounted to 44.8%. The resistance of collection samples to rust in the conditions of the Omsk region varied from low (2.8 points) in warm and humid weather to very high (7.8 points) in dry and hot weather. The main influence on the spread of rust is exerted by the hydrothermal conditions of the “flowering – ripening” period (r=-0.98±0.11). Plant resistance to rust varies greatly depending on growing conditions (Cve=20.2-54.6%). The variety Darunok had the least variability of the trait over the years (Cve=20.2%), which will most consistently maintain resistance when the infectious load increases. As a result of screening of collection material of vegetable peas, sources of partial resistance to rust were identified for breeding in Western Siberia: varieties Darunok, Namorodok (Federal Scientific Vegetable Center (FSBSI FSVC)), Orel, Cruiser, Vityaz, Flagman-8, Nemchinovsky 46, B-579, In Memory of Khangildin (VIR collection).
Intercondylar T-Type Distal Humerus Fracture in a 10-Year-Old
Authors: Yadav Aditya S. , Kollapaneni Sai Suraj , Wallace Doyle , Bryan Cory A. 
Published: July 2024

Case:
A 10-year-old, postmenarchal girl presented to the emergency department with a closed, displaced, intercondylar T-type distal humerus fracture. Open reduction and internal fixation was performed 3 days following initial presentation. The patient healed but experienced elbow stiffness in the 7 months following the procedure. Implant removal and capsular release were performed at that time. At the 31-month follow-up, the patient reported satisfactory elbow functionality.

Conclusion:
There is limited literature available discussing optimal management and associated outcomes of intercondylar T-type distal humerus fractures in the young-adolescent population. This report presents a possible method for management of the initial injury and the most common associated complication.
Contextualising Fajr Sadiq: Response to Dawn Research Findings with the Sky Quality Meter (SQM)
Authors: Maskufa Maskufa , Damanhuri Adi , Sopa Sopa , Hadi Ahmad Chairul 
Published: July 2024

The article needs to address the problem of dawn time too early in Indonesia. To prove this, the researcher used the Sky Quality Meter (SQM) in four locations with different sky brightness levels: Labuan Bajo, Belitung, Sidoarjo, and Bogor. In addition, the article also seeks to explain the views of the government and Islamic organization using SQM. This research uses normative, astronomical, and sociological approaches. The results showed that the value of the sun's tilt during the Dawn Sadiq period was -19.30º to -13.58º. The appearance of dawn can be detected earlier in locations with high sky brightness and low light pollution, such as in Labuan Bajo (-19.30º), while in other places with opposite conditions, the appearance of Dawn Sadiq is slower, such as in Bogor (-13.58º). If the SQM observation in Labuan Bajo is used as a reference, it will not significantly impact the current dawn schedule (dip = -20⁰). The use of SQM for dawn observation is acceptable to the Ministry of Religion and Islamic organizations. However, considering the mixed results of dawn research with SQM, the response of the Ministry of Religious Affairs, Nahdlatul Ulama, and the Islamic Association still uses dip = -20º, while Muhammadiyah shifts to dip = -18⁰. To minimize differences, it is necessary to conduct joint research on an ongoing basis to produce stable data on the setting of the sun at dawn.
Dynamic Real-Time Production Forecasting Model for Complex Subsurface Flow Systems with Variable Length Input Sequences
Authors: Xu Ziming , Leung Juliana Y. 
Published: July 2024

Summary
Production time-series forecasting for newly drilled wells or those with limited flow and pressure historical data poses a significant challenge, and this problem is exacerbated by the complexities and uncertainties encountered in fractured subsurface systems. While many existing models rely on static features for prediction, the production data progressively offer more informative insights as production unfolds. Leveraging ongoing production data can enhance forecasting accuracy over time. However, effectively integrating the production stream data presents significant model training and updating complexities. We propose two innovative methods to address this challenge: masked recurrent alignment (MRA) and masked encoding decoding (MED). These methods enable the model to continually update its predictions based on historical data. In addition, by incorporating sequence padding and masking, our model can handle inputs of varying lengths without trimming, thereby avoiding the potential loss of valuable training samples. We implement these models with gated recurrent unit (GRU) and evaluate their performance in a case study involving 6,154 shale gas wells in the Central Montney Region. The data set encompasses 39 production-related features, including reservoir properties, completion, and wellhead information. Performance evaluation is based on root mean square error (RMSE) to predict 36-month production from 200 wells during testing. Empirical findings highlight the efficacy of the proposed models in handling challenges associated with variable-length input sequences, showcasing their superior performance. Our research emphasizes the value of including shorter time-series segments, often overlooked, to improve predictive accuracy, especially in scenarios with limited training samples.
Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure
Authors: Luscher Bernhard , Jiang Tong , Feng Mengyang , Hutsell Alexander 
Published: July 2024

Abstract

Clinical and preclinical studies have identified somatostatin (SST)-positive interneurons as key elements that regulate the vulnerability to stress-related psychiatric disorders. Conversely, disinhibition of SST neurons in mice results in resilience to the behavioral effects of chronic stress. Here we established a low-dose chronic chemogenetic protocol to map these changes in positively and negatively motivated behaviors to specific brain regions. AAV-hM3Dq mediated chronic activation of SST neurons in the prelimbic cortex (PLC) had antidepressant drug-like effects on anxiety- and anhedonia-related motivated behaviors in male but not female mice. Analogous manipulation of the ventral hippocampus (vHPC) had such effects in female but not male mice. Moreover, activation of SST neurons in the PLC of male and the vHPC of female mice resulted in stress resilience. Activation of SST neurons in the PLC reversed prior chronic stress-induced defects in motivated behavior in males but was ineffective in females. Conversely, activation of SST neurons in the vHPC reversed chronic stress-induced behavioral alterations in females but not males. Quantitation of c-Fos+ and FosB+ neurons in chronic stress-exposed mice revealed that chronic activation of SST neurons leads to a paradoxical increase in pyramidal cell activity. Collectively, these data demonstrate that GABAergic microcircuits driven by dendrite targeting interneurons enable sex- and brain-region-specific neural plasticity that promotes stress resilience and reverses stress-induced anxiety- and anhedonia-like motivated behavior. Our studies provide a mechanistic rationale for antidepressant efficacy of dendrite-targeting, low-potency GABAA receptor agonists, independent of sex and despite striking sex differences in the relevant brain substrates.
A double edged sword: predation risk effects of a non-native species that acts as predator and prey
Authors: DiNuzzo Eleanor , Nogueria Haleigh , Donelan Sarah C , Sheriff Michael J 
Published: July 2024

Abstract

Non-native species are becoming increasingly pervasive worldwide. In an effort to help predict the impact of non-native species, they are often categorized into a single trophic level. However, many species can be both predator and prey to resident species, so generalizations made by assignments to either category alone may not accurately predict the effects of the non-native species. Here, we explored how a non-native species to New England rocky shores, the crab Hemigrapsus sanguineus that can be prey for the resident predator (Carcinus maenas) and also predator to the native prey (Nucella lapillus), impacts the risk responses of Nucella. We found that when Hemigrapsus was added to the food chain, Nucella spent similar time in refuge overall and consumed a similar amount of food but changed the specific refuge they used and grew less compared to exposure of Carcinus alone. When Nucella were exposed to Hemigrapsus alone, they altered the specific refuge they used but reduced their foraging and had similar growth compared to Carcinus alone. Exposure to each predator individually induced a fear response in Nucella, but these effects were non-additive when Nucella were exposed to both predators. We suggest this is due to a reduction in the predatory actions of both crabs on Nucella, given that Hemigrapsus could also have served as prey to Carcinus here. Our results demonstrate that only examining the dyadic interactions of non-native and resident species may not provide a good understanding of the actual impact of non-native species on resident food webs.