bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eosinophil Involvement in Atopic Dermatitis as Reflected by Elevated Serum Levels of Eosinophil Cationic Protein
Authors: Tsuda Shingo , Kato Keiko , Miyasato Minora , Sasai Yoichiro 
Published: April 2015

AbstractEosinophil cationic protein (ECP), one of the eosinophil granule proteins, is released during allergic reactions. We investigated the possibility of correlations among the serum levels of ECP, clinical activity, and eosinophil number in patients with atopic dermatitis (AD). Forty‐four patients with AD and 25 normal, non‐atopic subjects were studied. ECP was quantitated by a double antibody radioimmunoassay. The levels of serum ECP correlate with the grading of severity of clinical evaluations in AD. The patients with severe and moderate AD had significantly higher ECP concentrations than normal controls (p<0.001); mild AD had levels identical with those of control groups. A positive correlation was observed between the number of peripheral blood eosinophils and serum ECP levels in the severe cases (r=0.67, p<0.05). Furthermore, these ECP levels significantly decreased in response to either improvement of clinical severity of AD or decreased numbers of blood hypodense eosinophils in anti‐allergic drug‐treated patients. No coefficient of correlation was observed between serum ECP and IgE levels. These findings indicate that eosinophils may release their granular contents, including ECP, into the peripheral circulation and/or inflammatory skin lesions and subsequently provoke a clinical exacerbation by stimulating allergic reactions.
Cell Proliferative Activity of Epidermal Keratinocytes in Hair Discs
Authors: Suzuki Hiroyuki , Baba Shunichi , Murase Mami 
Published: April 2015

AbstractTo clarify the differences in epidermal keratinocyte proliferative activity and in postnatal developmental changes of this activity between the hair discs and the interfollicular epidermis, the incorporation of 3H‐thymidine into the nuclei of the basal cells was measured by autoradiography, and the percentages of basal cells thus labelled were calculated. This percentage was higher in hair discs than in interfollicular epidermis at all stages examined. The percentage of labelled basal cells in the hair discs was 10% up to 15 days after birth, decreasing to about 6% from 20 days postnatally. These results suggest that the degree of cell proliferation in the hair disc epidermis differs from that in the surrounding epidermis and that changes in proliferative activity during the postnatal developmental stages are well correlated with the morphogenesis of the hair discs.
Immunogenetic Study of Three Japanese Families with Neonatal Lupus Erythematosus
Authors: Nitta Yukiko , Ikeya Toshihiko , Santa Tetsuro , Ohashi Masaru , Usuda Toshikazu 
Published: April 2015

AbstractWe encountered three Japanese families with neonatal lupus erythematosus. None of the three fathers showed any signs of collagen disease. The three mothers were found to suffer from Sjögren's syndrome; they all tested positive for anti‐SSA and SSB antibodies and had lymphocyte infiltration into the small salivary gland. In two families, one child had neonatal lupus erythematosus while a sibling was normal; in the third family, both children had neonatal lupus erythematosus. Thus, a mother with positive anti‐SSA and SSB antibodies can give birth to one infant with and one infant without or have two infants with neonatal lupus erythematosus. We conducted HLA typing of all 12 members of the three families in order to clarify the immunologic factors involved. We found no increased frequency of any HLA phenotype in the three mothers and their four children with neonatal lupus erythematosus; however, HLA‐DR4 was present in three of the children with neonatal lupus erythematosus.
Eruptive Lichen Planus
Authors: Kanzaki Tamotsu , Otake Naoki , Nagai Morihito 
Published: April 2015

AbstractWe herein report a case of a rare variety of the acute eruptive form of lichen planus. The patient was a 51‐year‐old male who developed an intensely pruritic eruption on the lower legs which spread rapidly to all four extremities and trunk within a few months. The papulosquamous lesions were more than ten thousand in number. Topical steroid, cyclosporine, and systemic griseofulvin treatments were ineffective. However, there was a dramatic response to oral etretinate.
Blue‐gray Pigmentation in a Patient Receiving Doxorubicin
Authors: Konohana Akira 
Published: April 2015

AbstractA 64‐year‐old Japanese female who was treated for hepatocellular carcinoma with doxorubicin developed diffuse blue‐gray pigmentation of the face, fading out on the upper trunk. Skin biopsy revealed many melanin granules in the upper dermis. It is believed that the pigmentation was induced by doxorubicin.
Mucha‐Habermann Disease in a Child: Possible Association with Measles Vaccination
Authors: Torinuki Wakio 
Published: April 2015

AbstractA 2.5‐year‐old boy presented with skin lesions consistent with Mucha‐Habermann disease, which appeared about 5 days after an injection of freeze‐dried live attenuated measles vaccine. He responded to both oral and topical corticosteroid therapy. To my knowledge, this represents the first such association of Mucha‐Habermann disease with virus vaccination.
Oral Spironolactone Therapy in Male Patients with Rosacea
Authors: Aizawa Hiroshi , Niimura Michihito 
Published: April 2015

AbstractSpironolactone at 50 mg/day was orally administered for four weeks to 13 male patients with rosacea in order to observe its clinical effectiveness. Serum estradiol (E2), 17OH‐progesterone (17OH‐P4), testosterone (T), androstenedione (Δ4A), dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA‐S) were measured prior to and after treatment. Although there were no significant changes in T, Δ4A, DHT, or DHEA‐S, the serum levels of 17OH‐P4 increased significantly. E2 tended to increase, although the change was not significant Two of the 13 patients discontinued spironolactone treatment because of general malaise, but seven of the remaining eleven patients exhibited an improvement in their rosacea. These findings demonstrate that a low dose of spironolactone is effective in the treatment of rosacea in some male patients and suggest that it is possible that changes in the metabolism of sex steroid hormones such as cytochrome p‐450 isozymes have some bearing on the etiology of rosacea.
The Coexistence of Psoriasis Vulgaris, Sjögren's Syndrome, and Hashimoto's Thyroiditis
Authors: Nogita Toshitatsu , Aramoto Yoko , Terajima Satomi , Akimoto Kayoko , Kawashima Makoto , Hidano Akira , Matsugami Keiko , Mochizuki Takahiro 
Published: April 2015

AbstractA 52‐year‐old woman presented with psoriasis vulgaris, Sjögren's syndrome, and Hashimoto's thyroiditis with a 5‐year history. She had a number of immunological abnormalities and typical psoriatic plaques over her entire body. The relationship between psoriasis, Sjögren's syndrome, and Hashimoto's thyroiditis is discussed from the viewpoint of immunology, and similar cases in the literature are reviewed. This is the first report of a coexistence of psoriasis vulgaris, Sjögren's syndrome, and Hashimoto's thyroiditis.
Diaper Area Granuloma of Incontinence
Authors: Mostafa Wedad Z. , Abahussein Abdulaziz A. , Alzayer Ahmed A. 
Published: April 2015

AbstractGranulomas in the diaper area developed in four patients; two male infants following surgery for Hirschsprung's disease and two female children with urinary (and/or fecal) incontinence. The use of the term ‘Diaper area granuloma of incontinence’ is suggested to describe these lesions seen in the elderly, as well as in incontinent infants and children.
Genetic Polymorphisms in the Fourth Component of Complement (C4) and in Properdin Factor B (BF) in Japanese Patients with Palmoplantar Pustulosis
Authors: Torii Hideshi , Nakagawa Hidemi , Ishibashi Yasumasa , Tokunaga Katsushi , Juji Takeo 
Published: April 2015

AbstractGenetic polymorphisms in the fourth component of complement (C4) and in properdin factor B (BF) were investigated in 49 and 32 Japanese patients with palmoplantar pustulosis (PPP), respectively. C4B2 was significantly increased in frequency, whereas no significant deviations were detected in BF compared with the controls. These results may indicate that complement polymorphisms are involved in the pathogenesis of PPP.
Effects of Butylated Hydroxyanisole on Ornithine Decarboxylase Activity Induced by Ultraviolet‐B and PUVA in Mouse Skin
Authors: Kono Takeshi , Taniguchi Shoji , Mizuno Nobuyuki , Fukuda Michio , Maekawa Naoki , Hisa Tomoyuki , Ishii Masamitsu , Otani Shuzo , Hamada Toshio 
Published: April 2015

AbstractThe effects of butylated hydroxyanisole (BHA), a representative phenolic antioxidant, on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion and epidermal hyperproliferation) induced by ultraviolet‐B (UVB) or PUVA in mouse skin were investigated. By topical application of BHA (55 μmol), PUVA‐induced ODC activity was suppressed by about 60% at both 12 h and 24 h after treatment. In contrast, BHA failed to suppress UVB‐induced ODC activity in mouse skin. These results suggest that the induction of ODC activity by UVB or PUVA is mediated by different pathways.
Ultrastructural Aspects of Infiltrated Eosinophils in Bullous Pemphigoid
Authors: Iryo Kayoko , Tsuda Shingo , Sasai Yoichiro 
Published: April 2015

AbstractBy scanning (SEM) and transmission electron microscopy (TEM), we evaluated the infiltrated eosinophils in lesions at various stages of clinical development from patients with bullous pemphigoid (BP) and eosinophilia. Visualized by SEM, numerous inflammatory cells migrated through the cutaneous basement membrane into the cavity of newly formed blisters 12 to 24 hrs after formation. Many migrating cells attached to the reverse side of the bullous cavity, and some basal cells shed into the cavity. As the bullae developed 24 to 48 hrs after formation, the reverse surface of the bullous cavity became predominantly composed of these migrating cells and the exposed squamous cells. The migrating cells had villi, ruffles and ridge‐like profiles on their surfaces, which were suggested eosinophils. By TEM in the same lesions, many morphologically activated eosinophils were seen to have passed through the basement membrane into the newly formed blisters; they exhibited spheroidal cytoplasmic granules with less dense crystalloid cores and intracellular channels. Eosinophils infiltrating in the developed bullous cavity directly adhered to basal cells and released their granule contents onto these target cells. These findings suggest that inflammatory cells, especially eosinophils, may amplify the formation of dermalepidermal separation in BP lesions.
A Case of Dermatomyositis Associated with Pseudomyxoma Peritonei Originating from Mucinous Adenocarcinoma of the Appendix
Authors: Maekawa Yoshihiro , Nakamura Kayoko , Nogami Reiko 
Published: April 2015

AbstractA 69‐year‐old Japanese woman with erythema, severe edema on the face, Gottron's papules and poikiloderma was diagnosed as having dermatomyositis. She also noticed muscle weakness in her extremities, although her electromyogram showed neurogenic patterns. Her levels of CA19‐9 and CEA were elevated and a CT of her abdomen revealed a giant, multilobular, cystic lesion in the pelvis. This tumor was diagnosed as pseudomyxoma peritonei originating from a mucinous adenocarcinoma of the appendix.
Fasting Diet Therapy for Chronic Urticaria: Report of a Case
Authors: Okamoto Osamu , Murakami Isamu , Itami Satoshi , Takayasu Susumu 
Published: April 2015

AbstractWe used fasting diet therapy with a 28‐year‐old woman with chronic urticaria who responded only to systemic administration of glucocorticosteroids. The rashes began to decrease on the third therapeutic day and completely disappeared on the 11th day. Although the eruptions relapsed three days after the termination of the therapy, they were milder than previous ones. We also discussed the possible efficacy of fasting diet therapy for chronic urticaria as reported in the literature.
Giant Condyloma Acuminatum in a Baby Boy
Authors: Matsumura Noriko , Kumasaka Kumiko , Maki Hideo , Yoshie Osamu , Tagami Hachiro 
Published: April 2015

AbstractA giant condyloma acuminatum developed on the penis of a one and a half‐year‐old Japanese boy in two months. The histological features of this tumor were compatible with those of ordinary condyloma acuminatum. Although we detected the presence of human papilloma virus (HPV) type 16 by using the polymerase chain reaction system, we could not rule out the possibility that this HPV was present concurrently with other HPV types that cause condyloma acuminatum. The lesion was successfully treated with cryotherapy and topical application of 5% fluorouracil ointment under occlusion
Clear Cell Hidradenoma: A Tumor with Basaliomatous Changes in the Overlying Epidermis and Follicular Infundibula of Surrounding Skin
Authors: Kato Naoko , Ueno Hiroo 
Published: April 2015

AbstractWe report a clear cell hidradenoma on the cheek of a Japanese man. We performed the primary operation on the flesh‐colored tumor, which had surface telangiectasia. The histopathologic features of the tumor, which indicated an intradermal nodular hidradenoma, consisted mainly of typical clear cells with small numbers of eosinophilic fusiform cells. Most clear cells reacted negatively for CEA, EMA, S‐100 protein and KL‐1 keratin, but those in and around the cystic and ductal structures reacted positively for CEA, EMA and KL‐1 keratin. Ultrastructurally, these clear cells had numerous microvillus processes, abundant intracytoplasmic glycogen granules, and numerous mitochondria. In addition, buds of hyperpigmented keratinocytes hung from the overlying epidermis and thin cords of hyperpigmented keratinocytes proliferated around the follicular infundibula beside the tumor. Within two months of the primary operation, growth of the tumor into the overlying epidermis recurred rapidly. We discuss the histological features of the combination of clear cell hidradenoma with basaliomatous changes of the overlying and surrounding skin and the highly aggressive recurrence of this type of tumor after primary treatment.
Juvenile Dermatomyositis: A Statistical Study of 114 Patients with Dermatomyositis
Authors: Hiketa Takeshi , Matsumoto Yoshinari , Ohashi Masaru , Sasaki Ryuichiro 
Published: April 2015

AbstractWe conducted a statistical review of 114 cases of dermatomyositis (DMS) treated primarily at the Department of Dermatology at Nagoya University Hospital over 27 years from 1965 to 1991 in order to determine the primary characteristics of juvenile DMS with the following results.

Juvenile DMS was found slightly more often in males than females; the male‐to‐female ratio was 1.4: 1. Therefore, unlike adult DMS with its preponderance of females, there was no clear gender predominance.
Muscular manifestations tended to follow the appearance of cutaneous manifestations, but the frequency of minor muscular manifestations was high over the entire course of the disease.
Laboratory findings showed increases in serum aldolase and serum creatine kinase with significant frequency when compared with adult patients (p<0.01 and p<0.05, respectively). Elevated serum aldolase most often occurred prior to or at the time of the appearance of muscular manifestations, suggesting its usefulness in early diagnosis. The positive rates for the antinuclear antibody on HEp‐2 cells and anti‐DNA antibody were significantly lower in children than in adults (p<0.001 and p<0.05, respectively).
There were no cases of juvenile DMS complicated by malignant tumors, interstitial pneumonia, or pulmonary fibrosis. There were also no deaths, and the rate of “remission or improvement” was significantly higher than in adult DMS cases (p<0.05). Adult cases which remained the same or worsened usually presented with intractable muscular manifestations. In children, however, the cutaneous manifestations were more difficult to treat.
The above conclusions from this statistical study suggest the possibility that juvenile DMS is an entity separate from adult DMS.
A Case of Adult T Cell Leukemia with Bullae in the Palmoplantar Regions Followed by a Crisis
Authors: Yoshimura Kazuko , Oishi Munashi , Johno Masayoshi , Ono Tomomichi 
Published: April 2015

AbstractA 48‐year‐old Japanese female who had had chronic ATL for 4 years suddenly developed vesicles on the palms and soles. Histologically, these bullae were specific lesions of ATL. After a tendency to ward improvement, a crisis appeared with increases in the following: peripheral white blood cells, atypical lymphocytes, CD25 positive cells, serum LDH, and soluble IL‐2R. Palmoplantar bullae, a rather rare finding, may be indicative of a following crisis.
A Case of Trichoadenoma Arising in the Buttock
Authors: Yamaguchi Jun , Takino Chohei 
Published: April 2015

AbstractA 41‐year‐old Japanese man with trichoadenoma on his buttock was described. Histological examination showed numerous horn cysts and some tumor islands consisting entirely of eosinophilic epithelial cells. A review of 24 reported cases of trichoadenoma revealed that most of them developed on the facial region (14 of 24 cases, 58%); the buttock (6 of 24, 25%) was the next most common site.
Erythema Multiforme: Pathomechanism of Papular Erythema and Target Lesion
Authors: Imamura Sadao , Horio Takeshi , Yanase Keiko , Taniguchi Shinkichi , Miyachi Yoshiki , Tachibana Takao , Yoshioka Akira , Fujita Mayumi 
Published: April 2015

AbstractSkin lesions of erythema multiforme show time‐dependent changes from early papular erythema to the late target lesion which consists of a peripheral elevated erythematous area and a central depressed area. We investigated the pathomechanism of erythema multiforme, by examining the papular erythema and target lesion separately. In the early papular erythema, a small number of polymorphonuclear leukocytes and nuclear debris were seen intermingled with mononuclear cells around the slightly swollen blood vessels, on which immunoglobulin and complement components were deposited. Circulating immune complex levels were occasionally elevated. Sera from the patients generated high levels of reactive oxygen species and nitroblue tetrazolium test revealed positive reaction on the infiltrating cells around the blood vessels. These findings suggest that the papular erythema develops via incomplete type III allergic reaction, followed by damage through reactive oxygen species. In the target lesion, the activity of histamine‐N‐methyltransferase, which is the major histamine‐degrading enzyme, was markedly decreased in the peripheral elevated erythematous area and it was recovering in the central clearing area. ICAM‐1 and HLA‐DR antigens were expressed on the surfaces of the keratinocytes. An increased number of epidermal Langerhans cells and CD4 cell infiltration were observed in the peripheral elevated erythematous area, while a decreased number of epidermal Langerhans cells and CD8 cell infiltration in the central depressed area were observed. These findings suggest that impaired histamine metabolism and cellular allergic reactions play important roles in the development of the target lesion.
Classic Kaposi's Sarcoma: A Review of 90 Cases
Authors: Zurrida Stefano , Bartoli Cesare , Nolé Franco , Agresti Roberto , Prato Ivan Del , Colleoni Marco , Bajetta Emilio 
Published: April 2015

AbstractA series of 90 cases of classic Kaposi's sarcoma observed and treated over the last 25 years was examined retrospectively. Fifty‐one were the localized and 39 the disseminated form. Outpatient surgery for the localized and vinblastine chemotherapy for the disseminated form are probably the best treatments. Radiotherapy may be a valid alternative.
A Case of Cytophagic Histiocytic Panniculitis with Sicca Symptoms and Lupus Nephritis
Authors: Tsukahara Tetsuya , Fujioka Akira , Horiuchi Yasuhiro , Eto Hikaru , Nishiyama Shigeo , Akaboshi Tohoru , Kokubo Tohoru 
Published: April 2015

AbstractA 48‐year‐old Japanese woman presented with many subcutaneous nodules. The skin was purplish in color and tender; the nodules were scattered over the entire surface. Histological findings of biopsy specimens from the nodules indicated septal panniculitis comprised of histiocyte and/or macrophage infiltrates, often with erythro‐ and/or leukophagocytosis. Phagocytic cells were OKM1 (CD11b), MT1 (CD43), LeuM3 (CD14), and histiocyte antigen positive, indicating the presence of histiocytes and/or macrophages. The patient had sicca symptoms, positive homogenous, speckled pattern ANA (×320), and diffuse proliferative lupus nephritis.
The Clinical Expression in Anticentromere Antibody‐positive Patients Is Not Specified by the Epitope Recognition of CENP‐B Antigen
Authors: Muro Yoshinao , Sugimoto Kenji , Himeno Michio , Ohashi Masaru 
Published: April 2015

AbstractCentromere protein B (CENP‐B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often with scleroderma). From our previous analysis of the reactivity of anticentromere sera, four independent epitopes were identified on recombinant CENP‐B. The anticentromere sera displayed heterogeneity in their patterns of reactivity to the four epitopes. We have investigated to what extent this heterogeneity of the target autoepitope on CENP‐B accounts for the clinical diversity of anticentromere antibody (ACA)‐positive patients. A major autoepitope, epitope I, was recognized by all 40 ACA‐positive sera; however, the other three epitopes were recognized differently from case to case. We could not find any significant correlation between the reactivity to CENP‐B autoepitopes and the clinical presentation of ACA‐positive patients. There was considerable clinical diversity, even among the nine patients showing specificity for the single major autoepitope. In conclusion, we found that, although ACA‐positive patients were both clinically and immunologically heterogeneous, in most respects the clinical expression appeared to be independent of the reactivity to the CENP‐B autoepitope, a finding which suggests that identification of the target epitope of CENP‐B is unlikely to assist in the clinical classification of the disease in ACA‐positive patients. The identification of multiple B cell epitopes on CENP‐B is consistent with the concept that the self‐antigen drives the antibody response. However, factors other than CENP‐B autoepitope specificity must determine the clinical expression of ACA responses.
Growth and Collagen Synthesis of Cultured Neurofibroma Fibroblasts
Authors: Sasaki Tetsuo , Arai Katsuhiko , Nagai Yutaka 
Published: April 2015

AbstractCells from cutaneous neurofibromas of three patients with von Recklinghausen's disease and skin fibroblasts from four healthy adults were cultured. After two passages, DNA and collagen syntheses were determined by measuring incorporation of [3H] thymidine and [3H] proline respectively, and expressed as the values per unit DNA content. These values from neurofibroma cells were increased by 54% in DNA synthesis and 60% (p<0.05) in nondialyzable hydroxyproline synthesis, suggesting that neurofibroma cells in culture even after several passages still possess those characteristics corresponding to their pathological features in vivo. Collagen synthesized by neurofibroma cells appears to be normal as judged by intracellular degradation rates and SDS‐polyacrylamide gel electrophoresis.