bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective Nitrogen Functionalization of Graphene by Bucherer‐Type Reaction
Authors: Chua Chun Kiang , Sofer Zdeněk , Luxa Jan , Pumera Martin 
Published: March 2015

AbstractNitrogen functionalization of graphene offers new hybrid materials with improved performance for important technological applications. Despite studies highlighting the dependence of the performance of nitrogen‐functionalized graphene on the types of nitrogen functional groups that are present, precise synthetic control over their ratio is challenging. Herein, the synthesis of nitrogen‐functionalized graphene rich in amino groups by a Bucherer‐type reaction under hydrothermal conditions is reported. The efficiency of the synthetic method under two hydrothermal conditions was examined for graphite oxide produced by Hummers and Hofmann oxidation routes. The morphological and structural properties of the amino‐functionalized graphene were fully characterized. The use of a synthetic method with a well‐known mechanism for derivatization of graphene will open new avenues for highly reproducible functionalization of graphene materials.
Synthesis of 1‐C‐Glycoside‐Linked Lipid II Analogues Toward Bacterial Transglycosylase Inhibition
Authors: Lin Cheng‐Kun , Chen Kuo‐Ting , Hu Chia‐Ming , Yun Wen‐Yi , Cheng Wei‐Chieh 
Published: March 2015

AbstractPreparation of Lipid II analogues containing an enzymatically uncleavable 1‐C‐glycoside linkage between the disaccharide moiety and the pyrophosphate‐ or pyrophosphonate‐lipid moiety is described. The synthesis of a common 1‐C‐vinyl disaccharide intermediate has been developed that allows easy preparation of both an elongated sugar‐phosphate bond and a sugar‐phosphonate moiety, which are coupled with the polyprenyl phosphate to give the desired molecules. Inhibition studies show how a subtle structural modification results in dramatically different potency toward bacterial transglycosylase (TGase), and the results identify Lipid II‐C‐O‐PP (IC50=25 μM) as a potential TGase inhibitor.
Eliminating Voltage Decay of Lithium‐Rich Li1.14Mn0.54Ni0.14Co0.14O2 Cathodes by Controlling the Electrochemical Process
Authors: Wei Zhen , Zhang Wei , Wang Feng , Zhang Qian , Qiu Bao , Han Shaojie , Xia Yonggao , Zhu Yimei , Liu Zhaoping 
Published: March 2015

AbstractA lithium‐rich cathode material Li1.14Mn0.54Ni0.14Co0.14O2 (LNMCO) is prepared by a co‐precipitation method. The issue of voltage decay in long‐term cycling is largely eliminated by control of the charge–discharge voltage range. The LNMCO material exhibits 9.8 % decay in discharge voltage over 200 cycles between 2.0–4.6 V, during which the working voltage decays significantly, from 3.57 V to 3.22 V. The decay was decelerated by a factor of six by using a voltage window of 2.0–4.4 V, from 3.53 V to 3.47 V. IR and Raman spectra reveal that the transformation of layered structure to spinel is significantly retarded under 2.0–4.4 V cycling conditions. Transmission electron microscopy (TEM) was also applied for examining phase change in an individual particle during cycling, showing that the spinel phase occurs both at 2.0–4.6 V and at 2.0–4.4 V, but is not dominant in the latter. Normalization of Li can remove the additional impact on the voltage decay which is brought by different amounts of Li intercalation. The mechanism of no voltage decay at 2.0–4.4 V cycling is raised and electrochemical impedance spectrum data also support the hypothesis.
Plank‐Shaped Column‐Forming Mesogens with Substituents on One Side Only
Authors: Girotto Edivandro , Ferreira Marli , Sarkar Parantap , Bentaleb Ahmed , Hillard Elizabeth A. , Gallardo Hugo , Durola Fabien , Bock Harald 
Published: March 2015

AbstractProlonged glyoxylation of pyrenyl‐1‐glyoxylic acid ethyl ester leads to a mixture of isomers with polar pyrenylene‐1,8‐diglyoxylic acid as the main product, whereas the centrosymmetric 1,6‐isomer is obtained in good yield from the corresponding dibromopyrene. Perkin condensations followed by Pd‐catalyzed cyclizations lead to isomeric dinaphthopyrene‐tetracarboxdiimides that self‐assemble into columnar liquid crystals of hexagonal and rectangular symmetry, of which the rectangular mesophases have unusually elongated unit cells. The cisoid diimides with both alkylimide substituents on the same side of the oblong arene system show a much greater tendency to self‐assemble into fluid stacks of disks than their centrosymmetric isomers. With racemically branched alkyl substituents, uniform vertical surface alignment of the columns in the high‐temperature hexagonal mesophase is resilient to cycling through the lower‐temperature rectangular and crystalline phases.
Selective Functionalization of Hollow Nanospheres with Acid and Base Groups for Cascade Reactions
Authors: Gao Jinsuo , Zhang Xueying , Lu Yong , Liu Shaomin , Liu Jian 
Published: March 2015

AbstractThe inner‐surface functionalization of hollow silica spheres has rarely been reported and is still a challenging topic. Herein, we report a deacetalization–Henry cascade reaction catalyzed by dual‐functionalized mesoporous silica hollow nanospheres with basic amine groups (NH2) on the internal shell and carboxylic acid groups (COOH) on the external shell. The selective functionalization has been realized by a combination of “step‐by‐step post‐grafting” and “cationic surfactant‐assisted selective etching” strategy. Compared to unisolated catalyst, the selectively isolated acidic and basic dual catalyst provides excellent catalytic performance for the deacetalization–Henry cascade reaction in terms of both activity (>99 %) and selectivity (95 %).
Stereoselective Preparation of Polyfunctional Alkenylindium(III) Halides and Their Cross‐Coupling with Unsaturated Halides
Authors: Shen Zhi‐Liang , Knochel Paul 
Published: March 2015

AbstractThe direct insertion of indium powder to cycloalkenyl iodides in the presence of LiCl in THF allows the preparation of new highly functionalized cycloalkenylindium(III) derivatives. In addition, we discovered that, in contrast to many metal insertions to alkenyl iodides which proceed with a loss of stereochemistry, the insertion of In/LiCl to stereodefined (Z)‐ and (E)‐styryl iodides in THF proceeded with high retention of stereochemistry. After a palladium‐catalyzed cross‐coupling, various polyfunctionalized (Z)‐ and (E)‐stilbenes were obtained with high stereoselectivity.
ChemInform Abstract: Endohedral and Exohedral Metalloborospherenes: M@B40 (M: Ca, Sr) and M&B40 (M: Be, Mg).
Authors: Bai Hui , Chen Qiang , Zhai Hua‐Jin , Li Si‐Dian 
Published: March 2015

AbstractA DFT study on the viability of the metalloborospherenes: endohedral M@B40 (M: Ca, Sr) and exohedral M&B40 (M: Be, Mg) is presented.
ChemInform Abstract: Investigations on the Luminescence of Emission‐Tunable Ca10K(PO4)7:Eu2+, Sr2+, Mg2+ Phosphors for White LEDs.
Authors: Wang Yuchun , Li Hongyan , Zhang Rongrong , Zhan Maolin , Zhang Jia 
Published: March 2015

AbstractThe title phosphors are prepared by solid state reactions of CaCO3, K2CO3, SrCO3, (MgCO3)4·Mg (OH)2·5H2O, (NH4)2HPO4, and Eu2O3 in a reducing atmosphere (N2:H2 = 95:5, 1180 °C, 6 h) and characterized by powder XRD, diffuse reflectance spectroscopy in the range of 200—700 nm, and luminescence spectroscopy.
ChemInform Abstract: High Pressure Structures and Superconductivity of AlH3(H2) Predicted by First Principles.
Authors: Hou Pugeng , Zhao Xiusong , Tian Fubo , Li Da , Duan Defang , Zhao Zhonglong , Chu Binhua , Liu Bingbing , Cui Tian 
Published: March 2015

AbstractThe metallization, superconductivity, and high‐pressure structures of AlH3(H2) are explored at 25‐300 GPa by ab initio first principle calculations.
ChemInform Abstract: Molybdenum Source for Increase of Molybdenum Content in Electrodeposited Cu—Mo Composites.
Authors: Gotou Miku , Arakawa Tomiyuki , Watanabe Nobuaki , Hara Takatoshi , Tomita Tatsuya , Hashimoto Akira , Takanashi Hiroshi , Koiwa Ichiro 
Published: March 2015

AbstractCu‐Mo composites used as heat sinks in electronic devices are electrodeposited using Ni as cathode and Pt as anode from a bath containing Na2MoO4 or H3(PMo12O40), CuSO4, trisodium citrate, and/or EDTA, and/or glycolic acid at pH 9.
ChemInform Abstract: Hydrothermal Combination of Trilacunary Dawson Phosphotungstates and Hexanickel Clusters: From an Isolated Cluster to a 3D Framework.
Authors: Li Xin‐Xiong , Fang Wei‐Hui , Zhao Jun‐Wei , Yang Guo‐Yu 
Published: March 2015

AbstractThe new compounds (III), (IV), and (V) are hydrothermally synthesized and characterized by powder and single crystal XRD, IR spectroscopy, and diffuse reflectance spectroscopy.
ChemInform Abstract: Straightforward Access to Chiral Diol Bidentate Ligands: Their Efficient Enantioselective Induction in the Addition of Diethylzinc to Aromatic Aldehydes.
Authors: Goek Yasar , Kueloglu Soner , Goek Halil Zeki , Kekec Levent 
Published: March 2015

AbstractIn most cases, higher enantioselectivities are observed by using titanium isopropoxide as additive.
ChemInform Abstract: Ring‐Opening 1,3‐Dichlorination of Donor—Acceptor Cyclopropanes by Iodobenzene Dichloride.
Authors: Garve Lennart K. B. , Barkawitz Philip , Jones Peter G. , Werz Daniel B. 
Published: March 2015

AbstractAliphatic, aromatic, oxygen, and nitrogen containing substituents are successfully employed as donors in the title reaction.
ChemInform Abstract: Screening of N,N‐Bidentate and N,N,N‐Tridentate Pyridine‐Based Ligands in the Catalytic Allylic Oxidation of Cyclic Olefins.
Authors: Solinas Maurizio , Sechi Barbara , Chelucci Giorgio 
Published: March 2015

AbstractThe shown iminopyridine catalyst (CAM) gives the best results in the title reaction and enantioselectivities up to 53% are obtained.
ChemInform Abstract: Regioselective and Diastereoselective Aminoarylation of 1,3‐Dienes.
Authors: Bao Hongli , Bayeh Liela , Tambar Uttam K. 
Published: March 2015

AbstractA new and general method for the regioselective aminoarylation of cyclic and acyclic 1,3‐dienes via sequential [4 + 2] cycloaddition with sulfurdiimide (II) and subsequent Cu‐catalyzed allylic substitution with Grignard reagents is developed.
ChemInform Abstract: Copper(I) 2‐Hydroxyethoxide‐Promoted Cross‐Coupling of Aryl‐ and Alkenyldimethylsilanes with Organic Halides.
Authors: Takeda Takeshi , Obata Ryosuke , Muramatsu Daisuke , Takeda Yuichiro , Tsubouchi Akira 
Published: March 2015

AbstractThe reaction proceeds with retention of E/Z configuration of the substrates (VI), (VIII), and (X).
ChemInform Abstract: Remarkable Enhancement of Enantioselectivity in the Asymmetric Conjugate Addition of Dimethylzinc to (Z)‐Nitroalkenes with a Catalytic [(MeCN)4Cu]PF6‐Hoveyda Ligand Complex.
Authors: Zeng Xingzhong , et al. et al. 
Published: March 2015

AbstractThe new method for the title reaction features the unprecedented use of [Cu(MeCN)]PF6/LIG and (Z)‐nitroalkenes.
ChemInform Abstract: Mo(CO)6 Catalyzed Chemoselective Hydrosilylation of α,β‐Unsaturated Amides for the Formation of Allylamines.
Authors: Volkov Alexey , Tinnis Fredrik , Slagbrand Tove , Pershagen Ida , Adolfsson Hans 
Published: March 2015

AbstractA mild and chemoselective reduction of the α,β‐unsaturated tertiary and secondary amides to obtain the corresponding allylic amines is presented using tetramethyldisiloxane as the hydride source.
ChemInform Abstract: A Novel Pd‐Catalyzed N‐Dealkylative Carbonylation of Tertiary Amines for the Preparation of Amides.
Authors: Fang Tao , Gao Xu‐Hong , Tang Ri‐Yuan , Zhang Xing‐Guo , Deng Chen‐Liang 
Published: March 2015

AbstractVarious aryl iodides and alkyl tertiary amines are applicable in the title reaction to afford a series of N,N‐disubstituted amides with moderate to excellent yields.
ChemInform Abstract: Synthesis of Functionalized Carbamates and Quinones via Sequential Oxidation of Salicylaldehydes Using TBHP as the Oxidant.
Authors: Rajendra Prasad K. , Suresh P. , Ravikumar B. , Reddy N. Veera , Reddy K. Rajender 
Published: March 2015

AbstractThe oxidative amidation of salicylaldehydes with cyclic amines in the presence of tBuOOH gives a wide variety of salicylamides.
ChemInform Abstract: Copper‐Catalyzed Formation of C—O Bonds by Oxidative Coupling of Benzylic Alcohols with Ethers.
Authors: Wang Quan , Geng Haoran , Chai Wen , Zeng Xiaojun , Xu Min , Zhu Cheng , Fu Renzhong , Yuan Rongxin 
Published: March 2015

AbstractA series of α‐acyloxy ethers are obtained by the title reaction via a radical pathway.
ChemInform Abstract: Metal‐Free Amidation of Ether sp3 C—H Bonds with Sulfonamides Using PhI(OAc)2.
Authors: Campos Jesus , Goforth Sarah K. , Crabtree Robert H. , Gunnoe T. Brent 
Published: March 2015

AbstractAliphatic cyclic and aliphatic linear acyclic ethers react to the desired α‐branched products.
ChemInform Abstract: Oxidative (Cross‐)Coupling Reactions Mediated by C—H Activation of Thiophene Derivatives by Using Molybdenum(V) Reagents.
Authors: Schubert Moritz , Trosien Simon , Schulz Lara , Brandscheid Carolin , Schollmeyer Dieter , Waldvogel Siegfried R. 
Published: March 2015

AbstractThe use of MoCl5 renders possible the preparation of various synthetically important polycyclic thienoacenes.
ChemInform Abstract: One Pot Synthesis of 4‐(Arylidene)‐2‐ [5‐(4‐hydroxy‐6‐methyl‐2‐oxo‐2H‐pyran‐3‐yl)‐thiazol‐2‐yl] ‐5‐methyl‐2,4‐dihydro‐pyrazol‐3‐ones via Multi‐Component Approach.
Authors: Aychiluhim Tewodros Birhanu , Penta Santhosh , Rao Vedula Rajeswar 
Published: March 2015

AbstractThe efficient one‐pot, four‐component method for the synthesis of the title compounds (V) involves the simultaneous formation of the thiazole and the pyrazole ring system followed by condensation of various aromatic aldehydes on the active methylene group of pyrazolone under Knoevenagel reaction conditions.
ChemInform Abstract: Lewis Acid Promoted Construction of Chromen‐4‐one and Isoflavone Scaffolds via Regio‐ and Chemoselective Domino Friedel—Crafts Acylation/Allan—Robinson Reaction.
Authors: Chanda Tanmoy , Chowdhury Sushobhan , Koley Suvajit , Anand Namrata , Singh Maya Shankar 
Published: March 2015

AbstractStarting from a broad range of 3,5‐disubstituted phenols and aryl or alkyl substituted acetic acids this operationally simple strategy offers an efficient access to substituted chromen‐4‐one and isoflavone frameworks.
ChemInform Abstract: Synthesis of 2‐Alkylideneisochromans by Cyclocarbonylative Sonogashira Reactions.
Authors: Aronica Laura Antonella , Giannotti Luca , Giuntini Stefano , Caporusso Anna Maria 
Published: March 2015

AbstractThe advantages of the title synthesis are high yield, complete stereoselectivity, low catalyst loading (0.2‐0.5 mol%), and no need for CuI as co‐catalyst.
ChemInform Abstract: Six‐Membered Ring Formation from Lewis Acid Promoted Reactions of 2‐Substituted 2‐Alkenyl Amides and Esters of Ethenetricarboxylate.
Authors: Yamazaki Shoko , Ueda Kohta , Fukushima Yugo , Ogawa Akiya , Kakiuchi Kiyomi 
Published: March 2015

AbstractDepending on the functionality of the substrates used, either saturated or unsaturated six‐membered ring products are obtained selectively.
ChemInform Abstract: Microwave‐Assisted Chemoselective Synthesis of Novel Pyrazolo[3,4‐b]thieno[3,4‐e]pyridines: Substitution Induced Axial Chirality.
Authors: Rani Mani Anusha , Jeyachandran Veerappan , Muthu Muthumani , Sivakolunthu Subbiah , Kumar Raju Ranjith 
Published: March 2015

AbstractProducts deriving from 2‐substituted benzaldehydes display axial chirality due to restricted rotation.
ChemInform Abstract: A Highly Efficient Synthesis of Imidazo‐Fused Polyheterocycles via Groebke—Blackburn—Bienayme Reaction Catalyzed by LaCl3·7H2O.
Authors: Shinde Anand H. , Srilaxmi Malipatel , Satpathi Bishnupada , Sharada Duddu S. 
Published: March 2015

AbstractMedicinally and biologically relevant imidazo‐fused polyheterocycles are prepared in a one‐pot three component reaction.
ChemInform Abstract: Ligand‐Free Palladium Assisted Insertion of Isocyanides to Urea Derivatives For Cascade Synthesis of Phenylamino‐Substituted Quinazolinones.
Authors: Sharma Siddharth , Jain Abhilasha 
Published: March 2015

AbstractThe title reaction involves an isocyanide insertion/intramolecular cyclization/reductive elimination/Mazurciewitcz—Ganesan type rearrangement sequence to form quinazolines.
ChemInform Abstract: Palladium(II)‐Catalyzed Intermolecular Oxidative C‐3 Alkenylations of Imidazo[1,2‐a]pyridines by Substrate‐Contolled Regioselective C—H Functionalization.
Authors: Cao Hua , Lei Sai , Liao Jinqiang , Huang Jianping , Qiu Huifang , Chen Qinlin , Qiu Shuxian , Chen Yaoyi 
Published: March 2015

AbstractSubstrates such as vinylarenes (II) tend to form α‐products (III), while acrylates (IV) tend to form β‐products (V).
ChemInform Abstract: Competitive Silyl—Prins Cyclization versus Tandem Sakurai—Prins Cyclization: An Interesting Substitution Effect.
Authors: Diez‐Varga Alberto , Barbero Hector , Pulido Francisco J. , Gonzalez‐Ortega Alfonso , Barbero Asuncion 
Published: March 2015

AbstractAllylsilyl alcohols with different substitution patterns are treated with aldehydes under conditions A).
ChemInform Abstract: Formal Asymmetric Hydrobromination of Styrenes via Copper‐Catalyzed 1,3‐Halogen Migration.
Authors: Van Hoveln R. J. , Schmid S. C. , Tretbar M. , Buttke C. T. , Schomaker J. M. 
Published: March 2015

AbstractComputational modelling is undertaken to predict the correlation between reaction yields and features of the substrates and products.
ChemInform Abstract: Chemical Dynamic Kinetic Resolution and S/R Interconversion of Unprotected α‐Amino Acids.
Authors: Moriwaki Hiroki , et al. et al. 
Published: March 2015

AbstractHeating over 24 h is necessary to achieve full epimerization to the thermodynamically favoured isomer (R in the case of Sax‐ligand and S for the Rax‐ligand).
ChemInform Abstract: Concise and Enantioselective Total Synthesis of (‐)‐Mehranine, (‐)‐Methylenebismehranine, and Related Aspidosperma Alkaloids.
Authors: Mewald Marius , Medley Jonathan William , Movassaghi Mohammad 
Published: March 2015

AbstractThe first stereoselective synthesis of Aspidosperma alkaloid derivatives (‐)‐mehranine (I), (+)‐dihydroxy‐N‐methylaspidospermidine (II), and (‐)‐methylenebismehranine (III) from a chiral lactam precursor is described.
ChemInform Abstract: Chiral Ligands Derived from Monoterpenes: Application in the Synthesis of Optically Pure Secondary Alcohols via Asymmetric Catalysis
Authors: El Alami Mohammed Samir Ibn , El Amrani Mohamed Amin , Agbossou‐Niedercorn Francine , Suisse Isabelle , Mortreux Andre 
Published: March 2015

AbstractReview: [55 refs.
ChemInform Abstract: The Lithium/Air Battery: Still an Emerging System or a Practical Reality?
Authors: Grande Lorenzo , Paillard Elie , Hassoun Jusef , Park Jin‐Bum , Lee Yung‐Jung , Sun Yang‐Kook , Passerini Stefano , Scrosati Bruno 
Published: March 2015

AbstractReview: 218 refs.
ChemInform Abstract: Electrosprayed Nanoparticles and Electrospun Nanofibers Based on Natural Materials: Applications in Tissue Regeneration, Drug Delivery and Pharmaceuticals
Authors: Sridhar Radhakrishnan , Lakshminarayanan Rajamani , Madhaiyan Kalaipriya , Amutha Barathi Veluchamy , Lim Keith Hsiu Chin , Ramakrishna Seeram 
Published: March 2015

AbstractReview: 236 refs.
Kinetic Investigation Exploiting Local Parameter Subset Selection: Isomerization of 1‐Decene using a Rh‐Biphephos Catalyst
Authors: Jörke Andreas , Triemer Susann , Seidel‐Morgenstern Andreas , Hamel Christof 
Published: March 2015

AbstractA kinetic study of the isomerization of 1‐decene using a Rh‐Biphephos catalyst was performed in order to parameterize a mechanistic kinetic model to observed experimental data. For the derivation of the kinetic model, a previously proposed catalytic cycle was revised regarding the catalyst pre‐equilibrium including the formation of inactive or non‐selective Rh‐species. In order to estimate the model parameters and to support model reduction, a method based on parameter subset selection was extended and applied. Using this approach, sensitive kinetic parameters were identified and determined for the reduced kinetic model.
Indanones As High‐Potency Reversible Inhibitors of Monoamine Oxidase
Authors: Mostert Samantha , Petzer Anél , Petzer Jacobus P. 
Published: March 2015

AbstractRecent reports document that α‐tetralone (3,4‐dihydro‐2H‐naphthalen‐1‐one) is an appropriate scaffold for the design of high‐potency monoamine oxidase (MAO) inhibitors. Based on the structural similarity between α‐tetralone and 1‐indanone, the present study involved synthesis of 34 1‐indanone and related indane derivatives as potential inhibitors of recombinant human MAO‐A and MAO‐B. The results show that C6‐substituted indanones are particularly potent and selective MAO‐B inhibitors, with IC50 values ranging from 0.001 to 0.030 μM. C5‐Substituted indanone and indane derivatives are comparatively weaker MAO‐B inhibitors. Although the 1‐indanone and indane derivatives are selective inhibitors of the MAO‐B isoform, a number of homologues are also potent MAO‐A inhibitors, with three homologues possessing IC50 values <0.1 μM. Dialysis of enzyme–inhibitor mixtures further established a selected 1‐indanone as a reversible MAO inhibitor with a competitive mode of inhibition. It may be concluded that 1‐indanones are promising leads for the design of therapies for neurodegenerative and neuropsychiatric disorders such as Parkinson’s disease and depression.
Hydrogenated Graphene and Hydrogenated Silicene: Computational Insights
Authors: Nguyen Manh‐Thuong , Phong Pham Nam , Tuyen Nguyen Duc 
Published: March 2015

AbstractDensity functional calculations are performed to study the energetic, structural, and electronic properties of graphene and silicene functionalized with hydrogen. Our calculations predict that H atoms bind much more strongly to silicene than to graphene. The adsorbed H atoms tend to cooperatively stabilize each other leading to a two‐dimensional nucleation and growth mechanism. The different structural and electronic modifications induced by H in fully functionalized graphene and silicene (known as graphane and silicane) are also explained. Finally, the electronic properties of defective graphane with multiple hydrogen vacancies are investigated. Engineering the vacancies in graphane offers a way to modify the electronic properties of this material.
Comparison between bioluminescence imaging technique and CFU count for the study of oropharyngeal candidiasis in mice
Authors: Gabrielli Elena , Roselletti Elena , Luciano Eugenio , Sabbatini Samuele , Mosci Paolo , Pericolini Eva 
Published: March 2015

AbstractWe recently described a bioluminescence in vivo imaging technique, representing a powerful tool to test the real‐time progression of oropharyngeal candidiasis, hence potentially useful to evaluate the efficacy of antifungal therapies. In this study, the in vivo imaging technique was compared with CFU measurement of target organs (tongue, esophagus and stomach) for monitoring and quantifying oropharyngeal candidiasis. We have correlated these two analytical methods at different times post‐infection using engineered, luminescent Candida albicans in mice rendered susceptible to oral candidiasis by cortisone‐acetate. Scatter plots, Pearson correlation and Student's t test were used to compare the methods. We observed that the bioluminescence in vivo imaging technique was more reliable than CFU counts in detecting early infection of, and its extent in, the oral cavity of the mouse. This was also evident following the introduction of a variable such as treatment with fluconazole. The results described in this study could validate the bioluminescence in vivo imaging technique as a method to monitor and quantify oropharyngeal candidiasis and to assess early discovery of active compounds in vivo. © 2015 International Society for Advancement of Cytometry