bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of psoriasis with allergic multimorbidity of asthma, rhinitis, and eczema among adolescents: a cross-sectional study
Authors: Ziyab Ali H. , Ali Yaser , Zein Dina , Al-Kandari Manal , Holloway John W. , Karmaus Wilfried 
Published: July 2024

Abstract
Background
Associations between psoriasis and allergic diseases (asthma, rhinitis, and eczema) in children have been reported in a limited number of studies, and the association between psoriasis and multimorbidity (co-occurrence) of allergic diseases remains unclear. Hence, this study aimed to assess the association between psoriasis and the co-occurrence of asthma, rhinitis, and eczema in adolescents.

Methods
This school-based cross-sectional study enrolled adolescents (n = 3,864) aged 11–14 years. Parents completed a questionnaire on doctor-diagnosed psoriasis as well as symptoms and clinical history of asthma, rhinitis, and eczema. Eight nonoverlapping groups comprising single and co-occurring current (past 12 months) asthma, rhinitis, and eczema were identified. A multinomial logistic regression model was used to estimate the adjusted odds ratios (aOR) and 95% confidence intervals (CI).

Results
In the analytical sample (n = 3,710; 1,641 male and 2,069 female participants), 3.5% reported doctor-diagnosed psoriasis, and 15.7%, 15.0%, and 10.3% had current asthma, rhinitis, and eczema symptoms, respectively. Doctor-diagnosed psoriasis was associated with “asthma only” (aOR = 2.11, 95% CI: 1.15–3.89), “eczema only” (6.65, 4.11–10.74), “asthma + eczema” (5.25, 2.36–11.65), “rhinitis + eczema” (3.60, 1.07–12.15), and “asthma + rhinitis + eczema” (7.38, 2.93–18.58). Doctor-diagnosed psoriasis was not statistically significantly associated with “rhinitis only” (1.42, 0.71-–2.84) and “asthma + rhinitis” (1.78, 0.69–4.56).

Conclusion
Our findings indicate that psoriasis is associated with the co-occurrence of allergic diseases among adolescents. However, further studies are required to investigate which biological mechanisms may be shared between psoriasis and allergic diseases.
Barriers to HPV vaccine series completion among a predominantly hispanic border population: a mixed method evaluation
Authors: Hernandez Amir , Calderón-Mora Jessica , Lara Hatty , Drury Nicole , Molokwu Jennifer 
Published: July 2024

Abstract
Background
Human Papillomavirus (HPV) infections are the most common sexually transmitted infections in the United States. The HPV vaccine is a vital tool to prevent against several cancers, namely cervical cancer. Unfortunately, the uptake of the HPV vaccine among Hispanics is relatively low. Some barriers to uptake include language barriers, cultural taboos, and cost.

Purpose
This study aims to explore barriers to HPV vaccination in a predominantly Hispanic US-Mexico border county between June 2015 and March 2018.

Methods
A mixed-method approach was used to analyze covariates associated with HPV vaccine uptake and to evaluate barriers to HPV vaccination from participant follow-up calls or reminder notes.

Results
The total number of participants was 1,787. Young adults were less likely to complete the vaccination series than those aged 9-17, while individuals born in Mexico were more likely to do so. Failure to contact was the most common barrier (n=1,801, 86.42%), followed by scheduling concerns (n=99, 4.5%), being ineligible (74, 3.55%), completing series outside of the program (40, 1.92%), having medical concerns (36, 1.73%), and other reasons (34, 1.63%).

Conclusion
We predominantly identified structural barriers and various health-related determinants regarding healthcare access and quality.
Enabling radical and potentially disruptive innovations through interdisciplinarity: challenges and practices in industrial companies
Authors: Schimpf Sven , Weber Hanno , Gerlach Thomas 
Published: July 2024

AbstractThe motivation behind this paper and the underlying research is to shed light on how companies deal with interdisciplinary innovation activities, especially looking at the development of radical and potentially disruptive innovations. This includes the analysis of methods, processes, and organizational structures applied to support interdisciplinary innovation activities as well as challenges faced. Whereas this thematic field has been widely investigated for academic institutions and, in companies on a team level, there is only a little information on industrial companies’ current state. This understanding is especially important as shortening development cycles, and technological convergence combined with intersectoral innovations might lead to increases in radical and potentially disruptive innovations and thereby create the need for improved methods and structures throughout the innovation process. To gain insights into challenges and current practices of interdisciplinary collaboration in innovation activities, semi-structured exploratory interviews were carried out with representatives from seven industrial companies. Among others, the results of the study revealed that whereas many methodologies are said to support interdisciplinary innovation activities, a wide majority of these methodologies are applied for other reasons which make supporting interdisciplinarity seem like a kind of byproduct.
Exploring biomarkers for diagnosing and predicting organ dysfunction in patients with perioperative sepsis: a preliminary investigation
Authors: Jiang Linghui , Chen Shiyu , Li Shichao , Wang Jiaxing , Chen Wannan , Shi Yuncen , Xiong Wanxia , Miao Changhong 
Published: July 2024

Abstract
Objective
Early diagnosis and prediction of organ dysfunction are critical for intervening and improving the outcomes of septic patients. The study aimed to find novel diagnostic and predictive biomarkers of organ dysfunction for perioperative septic patients.

Method
This is a prospective, controlled, preliminary, and single-center study of emergency surgery patients. Mass spectrometry, Gene Ontology (GO) functional analysis, and the protein-protein interaction (PPI) network were performed to identify the differentially expressed proteins (DEPs) from sepsis patients, which were selected for further verification via enzyme-linked immunosorbent assay (ELISA). Logistic regression analysis was used to estimate the relative correlation of selected serum protein levels and clinical outcomes of septic patients. Calibration curves were plotted to assess the calibration of the models.

Results
Five randomized serum samples per group were analyzed via mass spectrometry, and 146 DEPs were identified. GO functional analysis and the PPI network were performed to evaluate the molecular mechanisms of the DEPs. Six DEPs were selected for further verification via ELISA. Cathepsin B (CatB), vascular cell adhesion protein 1 (VCAM-1), neutrophil gelatinase-associated lipocalin (NGAL), protein S100-A9, prosaposin, and thrombospondin-1 levels were significantly increased in the patients with sepsis compared with those of the controls (p < 0.001). Logistic regression analysis showed that CatB, S100-A9, VCAM-1, prosaposin, and NGAL could be used for preoperative diagnosis and postoperative prediction of organ dysfunction. CatB and S100-A9 were possible predictive factors for preoperative diagnosis of renal failure in septic patients. Internal validation was assessed using the bootstrapping validation. The preoperative diagnosis of renal failure model displayed good discrimination with a C-index of 0.898 (95% confidence interval 0.843–0.954) and good calibration.

Conclusion
Serum CatB, S100-A9, VCAM-1, prosaposin, and NGAL may be novel markers for preoperative diagnosis and postoperative prediction of organ dysfunction. Specifically, S100-A9 and CatB were indicators of preoperative renal dysfunction in septic patients. Combining these two biomarkers may improve the accuracy of predicting preoperative septic renal dysfunction.

Trial registration
The study was registered at the Chinese Clinical Trials Registry (ChiCTR2200060418) on June 1, 2022.
Dorsal raphe nucleus–hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5×FAD male mice
Authors: Chen Meiqin , Wang Chenlu , Lin Yinan , Chen Yanbing , Xie Wenting , Huang Xiaoting , Zhang Fan , Fu Congrui , Zhuang Kai , Zou Tingting , Can Dan , Li Huifang , Wu Shengxi , Luo Ceng , Zhang Jie 
Published: July 2024

Abstract
Background
Depressive symptoms often occur in patients with Alzheimer's disease (AD) and exacerbate the pathogenesis of AD. However, the neural circuit mechanisms underlying the AD-associated depression remain unclear. The serotonergic system plays crucial roles in both AD and depression.

Methods
We used a combination of in vivo trans-synaptic circuit-dissecting anatomical approaches, chemogenetic manipulations, optogenetic manipulations, pharmacological methods, behavioral testing, and electrophysiological recording to investigate dorsal raphe nucleus serotonergic circuit in AD-associated depression in AD mouse model.

Results
We found that the activity of dorsal raphe nucleus serotonin neurons (DRN5-HT) and their projections to the dorsal hippocampal CA1 (dCA1) terminals (DRN5-HT-dCA1CaMKII) both decreased in brains of early 5×FAD mice. Chemogenetic or optogenetic activation of the DRN5-HT-dCA1CaMKII neural circuit attenuated the depressive symptoms and cognitive impairments in 5×FAD mice through serotonin receptor 1B (5-HT1BR) and 4 (5-HT4R). Pharmacological activation of 5-HT1BR or 5-HT4R attenuated the depressive symptoms and cognitive impairments in 5×FAD mice by regulating the DRN5-HT-dCA1CaMKII neural circuit to improve synaptic plasticity.

Conclusions
These findings provide a new mechanistic connection between depression and AD and provide potential pharmaceutical prevention targets for AD.
Cheating in online assessment: a qualitative study on reasons and coping strategies focusing on EFL teachers’ perceptions
Authors: Jalilzadeh Kaveh , Rashtchi Mojgan , Mirzapour Fatemeh 
Published: July 2024

AbstractA challenging aspect of online education is assessment since academic integrity could be violated due to students’ cheating behaviors. The current qualitative research investigated English teachers’ perceptions of why students cheat in online assessments. Besides, it attempted to find strategies to reduce cheating in online assessments. Twelve teachers (seven males and five females) with at least 5 years of teaching experience in different high schools in Tabriz, Iran, participated in the study. Data were collected through semi-structured interviews and were analyzed using MAXQDA version 2022. Freedom in the absence of an invigilator, unpreparedness for assessment, getting better grades/outcomes, low self-esteem/self-confidence, shortage of time/poor time management, peer influence or competition, not taking assessment seriously, fear of failure/bad assessment outcomes, and lack of respect for academic rules/the teacher were some reasons of cheating in online assessment revealed by the analysis of the data. The teachers suggested strategies to curb cheating in online assessment, such as randomizing questions, using open-ended and essay-format questions, designing different test methods and question types, restricting exam time, designing learner-specific questions, showing one question at a time, and providing clear exam instructions. The study has some pedagogical implications for faculty members and administrators.
Chemical analysis of fragments of glass and ceramic ware from Tycho Brahe’s laboratory at Uraniborg on the island of Ven (Sweden)
Authors: Rasmussen Kaare Lund , Grinder-Hansen Poul 
Published: July 2024

Abstract
In addition to his astronomical observations the famous Renaissance astronomer Tycho Brahe (1546–1601) was known also for his interest in alchemy. He equipped his castle Uraniborg on the island of Ven with a state-of-the-art alchemical laboratory when it was erected around 1580. After Brahe’s death Uraniborg was demolished upon a royal decree from 1601, a process which was completed around 1650. In the present study we have analysed four glass shards and one ceramic shard most likely from the alchemical laboratory and retrieved during an archaeological excavation in 1988–90. Cross sections of the shards have been analysed for 31 trace elements by Laser Ablation Inductively Coupled Plasma with Mass Spectrometry with the aim of detecting any traces of the chemical substances on the inside or outside of the shards used in the laboratory. Four of the elements found in excess on the exterior surfaces of the shards, Cu, Sb, Au, and Hg, are in accordance with the reconstructed recipes of the three Paracelsian medicines for which Brahe was famous—Medicamenta tria. This is the first experimental data casting light on the alchemical experiments that took place at Uraniborg 1580–1599.
Chemiluminescence method for evaluating photooxidative degradation of dispensed drugs: a potential new drug information tool
Authors: Murai Yuriko , Kudo Kasumi , Suzuki Hiroyuki , Konno Taisuke , Agatsuma Yasuyuki , Nakamura Hitoshi 
Published: July 2024

Abstract
Background
Dispensed drugs stored by patients are often in single-dose packages (SDPs) or are crushed and mixed after being removed from a press-through package (PTP) sheet. Information on their stability is extremely limited. To address this, we explored using chemiluminescence (CL) measurements to detect oxidative degradation.

Methods
Eight amlodipine, 14 telmisartan, and two warfarin preparations were used as specimens. These preparations were stored at room temperature under various conditions, after which CL was measured. Cellopoly packaging paper was used for SDP. Three light conditions were used (Condition A: darkness, Condition B: indoor diffused light (approximately 400 lx), and Condition C: exposure to 4,000 lx). CL cumulative light output was measured every minute under nitrogen gas conduction and with a sample chamber temperature of 150 °C, for a maximum of 10 min. Luminescence images were obtained simultaneously with the CL measurements.

Results
CL was observed on light-exposed tablet surfaces. For each preparation, an increase in the CL value was observed with the duration of light exposure. In the same preparation with the same exposure time, CL tended to be higher in the order of Condition A < B < C. Moreover, CL increased even when no changes in color were observed by the naked eye. A comparison between preparations with the same main ingredients showed differences in the rate of increase in CL with exposure, and each was found to show a different reactivity to light.

Conclusions
To the best of our knowledge, this is the first study to visually capture the surface oxidation of tablets exposed to light using the CL method. The CL values, thought to be derived from photooxidation, increased with exposure of tablets and powders to light after SDP. This method can sensitively assess drug degradation due to photooxidation. Further research is needed to establish a CL method for assessing the stability of preparations in clinical settings.
Cultures as types and the utility of viable specimens for fungal nomenclature
Authors: Yurkov Andrey , Visagie Cobus M. , Crous Pedro W. , Hashimoto Akira , Baschien Christiane , Begerow Dominik , Kemler Martin , Schoutteten Nathan , Stadler Marc , Wijayawardene Nalin N. , Hyde Kevin D. , Zhang Ning , Boekhout Teun ,   ICTF Yeast Working Group, Yurkov Andrey , Boekhout Teun , Bai Feng-Yan , Begerow Dominik , Čadež Neža , Daniel Heide-Marie , Fell Jack W. , Groenewald Marizeth , Lachance Marc-André , Libkind Diego , Péter Gábor , Takashima Masako , Turchetti Benedetta , May Tom W. , Thines Marco , Hawksworth David L. 
Published: July 2024

AbstractThe debates over the requirement of the International Code of Nomenclature for algae, fungi, and plants (ICNafp) for a viable specimen to represent the name-bearing type material for a species or infraspecific taxon have a long history. Taxonomy of fungi commonly studied as living cultures exemplified by yeasts and moulds, strongly depend on viable reference material. The availability of viable cultures is also particularly useful for several groups of filamentous and dimorphic fungi. While the preservation of metabolically inactive cultures is permitted and recommended by the ICNafp, there is room for improvement. Below, we review the history and current status of cultures as the name-bearing type material under the Code. We also present a roadmap with tasks to be achieved in order to establish a stable nomenclatural system that properly manages taxa typified by viable specimens. Furthermore, we propose setting up rules and defining the nomenclatural status of ex-type cultures under Chapter F, the section of the ICNafp that includes provisions specific to names of fungi.
Utility of the 70-Gene MammaPrint Assay for Prediction of Benefit From Extended Letrozole Therapy in the NRG Oncology/NSABP B-42 Trial
Authors: Rastogi Priya , Bandos Hanna , Lucas Peter C. , van ‘t Veer Laura J. , Wei Jia-Perng J. , Geyer Charles E. , Fehrenbacher Louis , Chia Stephen K.L. , Brufsky Adam M. , Walshe Janice M. , Soori Gamini S. , Dakhil Shaker R. , Paik Soonmyung , Swain Sandra M. , Menicucci Andrea R. , Audeh M. William , Wolmark Norman , Mamounas Eleftherios P. 
Published: July 2024

PURPOSE
MammaPrint (MP) determines distant metastatic risk and may improve patient selection for extended endocrine therapy (EET). This study examined MP in predicting extended letrozole therapy (ELT) benefit in patients with early-stage breast cancer (BC) from the NSABP B-42 trial.

PATIENTS AND METHODS
MP was tested in 1,866 patients randomly assigned to receive ELT or placebo. The primary end point was distant recurrence (DR). Secondary end points were disease-free survival (DFS) and BC-free interval (BCFI). Tumors were classified as MP high risk (MP-HR) or low risk (MP-LR). MP-LR tumors were further classified as ultralow risk (MP-UL) or low non-ultralow risk (MP-LNUL).

RESULTS

There was no statistically significant difference in ELT benefit on DR between MP-HR and MP-LR (interaction
P =
.38). MP-LR tumors (n = 1,160) exhibited a statistically significant 10-year benefit of 3.7% for DR (hazard ratio [HR], 0.43 [95% CI, 0.25 to 0.74];
P
= .002), whereas MP-HR tumors (n = 706) exhibited a nonsignificant 2.4% benefit (HR, 0.65 [95% CI, 0.34 to 1.24];
P
= .19). The 10-year ELT benefit was significant for DFS (7.8%) and BCFI (7.0%) for MP-LR tumors, whereas MP-HR tumors did not significantly benefit (interaction DFS:
P
= .015, BCFI:
P
= .006). In exploratory analysis, the 10-year ELT benefit was significant and more pronounced in MP-LNUL (n = 908) tumors: 4.0% for DR, 9.5% for DFS, and 7.9% for BCFI; the benefit in MP-UL (n = 252) tumors was not significant: 3% for DR, 1.8% for DFS, and 4.1% for BCFI.

CONCLUSION
The primary hypothesis of predictive ability of MP on DR was not confirmed. However, the secondary outcomes demonstrated MP was predictive of ELT response and identified a subset of patients with early-stage hormone receptor–positive BC (MP-LR) with improved outcomes from ELT. These data could have important clinical implications in patient selection beyond clinical risk assessment for EET.
Risk Without Reward: Differing Patterns of Chemotherapy Use Do Not Improve Outcomes in Stage II Early-Onset Colon Cancer
Authors: Leary Jacob B. , Hu Junxiao , Leal Alexis , Davis S. Lindsey , Kim Sunnie , Lentz Robert , Friedrich Tyler , Herter Whitney , Messersmith Wells A. , Lieu Christopher H. 
Published: July 2024

PURPOSE Rising rates of early-onset colon cancer (EOCC) present challenges in deciding how to optimally treat patients. Although standard of care for stage II CC is surgical resection, adding chemotherapy for high-risk disease, evidence suggests treatment selection may differ by age. We investigated whether adjuvant chemotherapy (AC) administration rates differ between patients with early- and later-onset stage II CC. METHODS Data originated from the nationwide Flatiron Health electronic health record (EHR)–derived deidentified database spanning January 1, 2003, to August 1, 2021. Adults with stage II CC were grouped as age 18-49 years (EOCC) and those age 50 years or older (later-onset colon cancer [LOCC]). Demographics, Eastern Cooperative Oncology Group score, tumor stage and site, and chemotherapy were included. Primary outcomes included rates of AC administration by age and ethnicity; secondary outcomes included overall survival (OS) and time to metastatic disease (TTMD). Univariate and multivariable logistic regression models evaluated relationships between chemotherapy administration, age, and ethnicity, adjusting for significant covariates. RESULTS One thousand sixty-five patients were included. Median age of patients with EOCC was 45.0 years versus 69.0 years for patients with LOCC. Adjusted multivariate analysis showed patients with EOCC received AC significantly more often than patients with LOCC. Non-Hispanic patients received AC at significantly lower rates than Hispanic patients in both cohorts. Subanalysis of stage IIA patients showed that patients with EOCC were more likely to receive AC than patients with LOCC. No significant differences in OS or TTMD were observed by age regardless of AC administration in stage II overall; however, patients with stage IIA EOCC receiving AC had significantly longer TTMD than those not receiving AC. CONCLUSION AC was given preferentially in stage II EOCC, even in stage IIA, despite deviation from guidelines. This may expose low-risk patients to unnecessary toxicities and suggests bias toward treating younger patients more aggressively, despite unclear evidence for better outcomes.
Intestinal Absorption Site-Guided Development and Evaluation of Oral Disintegrating Controlled Release Tablets of Mirabegron
Authors: Ghanem Mohammed I. , Ashmawy Shimaa M. , El Maghraby Gamal M. 
Published: July 2024

AbstractThe aim was to employ site-dependent absorption of mirabegron (MB) as a guide for fabrication of oral disintegrating controlled release tablet (ODCRT) which undergoes instantaneous release of loading fraction followed by delayed release of the rest of MB. The goal was to release MB in a manner consistent with the chronobiology of overactive bladder (OAB) syndrome. In situ rabbit intestinal permeability of MB was adopted to assess absorption sites. MB was subjected to dry co-grinding with citric acid to develop the fast-dissolving fraction in the mouth. Delayed release fraction was formulated by ethanol-assisted co-processing with increasing proportions of Eudragit polymer (S100) as pH responsive polymer. The developed dry mixtures underwent thermal (DSC) and physical (X-ray diffraction) characterization, in addition to in vitro release behavior. Optimized fast dissolving and delayed release formulations were mixed with tablet excipient before compression in ODCRT which was assessed for release profile using continuous pH variation. MB underwent preferential permeation through ileum and colon. Co-grinding with citric acid provided co-amorphous powder with fast dissolution. Co-amorphization of MB with Eudragit S100 (1:5) showed pH-dependent release to release most of the dose at pH 7.4. The developed ODCRT released 43.5% of MB in the buccal environment and retained MB at acidic pH to start release at pH 7.4. The study successfully fabricated ODCRT guided by site-dependent absorption. The ODCRT instantaneously released loading fraction to support the patient after administration with delayed fraction to sustain the effect.
Graphical Abstract