bluuebunny/crossref_metadata_2025_split huggingface dataset:
Every edge lies on cycles embedding in folded hypercubes with both vertex and edge faults
Authors: Kuo Che-Nan 
Published: October 2015

The folded hypercube is a well-known variation of hypercube structure and can be constructed from a hypercube by adding an edge to every pair of vertices with complementary addresses. Let [Formula: see text] (respectively, [Formula: see text]) denote the set of faulty vertices (respectively, faulty edges) in an [Formula: see text]-dimensional folded hypercube [Formula: see text]. In the case that all edges in [Formula: see text] are fault-free, Cheng et al. [Cycles embedding on folded hypercubes with faulty vertices, Discrete Appl. Math. 161 (2013) 2894–2900] has shown that (1) every fault-free edge of [Formula: see text] lies on a fault-free cycle of every even length from [Formula: see text] to [Formula: see text] if [Formula: see text], where [Formula: see text]; and (2) every fault-free edge of [Formula: see text] lies on a fault-free cycle of every odd length from [Formula: see text] to [Formula: see text] if [Formula: see text], where [Formula: see text] is even. In this paper, we extend Cheng’s result to obtain two further properties, which consider both vertex and edge faults, as follows: (1) Every fault-free edge of [Formula: see text] lies on a fault-free cycle of every even length from [Formula: see text] to [Formula: see text] if [Formula: see text], where [Formula: see text]; (2) Every fault-free edge of [Formula: see text] lies on a fault-free cycle of every odd length from [Formula: see text] to [Formula: see text] if [Formula: see text], where [Formula: see text] is even.
Video-audio driven real-time facial animation
Authors: Liu Yilong , Xu Feng , Chai Jinxiang , Tong Xin , Wang Lijuan , Huo Qiang 
Published: October 2015

We present a real-time facial tracking and animation system based on a Kinect sensor with video and audio input. Our method requires no user-specific training and is robust to occlusions, large head rotations, and background noise. Given the color, depth and speech audio frames captured from an actor, our system first reconstructs 3D facial expressions and 3D mouth shapes from color and depth input with a multi-linear model. Concurrently a speaker-independent DNN acoustic model is applied to extract phoneme state posterior probabilities (PSPP) from the audio frames. After that, a lip motion regressor refines the 3D mouth shape based on both PSPP and expression weights of the 3D mouth shapes, as well as their confidences. Finally, the refined 3D mouth shape is combined with other parts of the 3D face to generate the final result. The whole process is fully automatic and executed in real time.
The key component of our system is a data-driven regresor for modeling the correlation between speech data and mouth shapes. Based on a precaptured database of accurate 3D mouth shapes and associated speech audio from one speaker, the regressor jointly uses the input speech and visual features to refine the mouth shape of a new actor. We also present an improved DNN acoustic model. It not only preserves accuracy but also achieves real-time performance.
Our method efficiently fuses visual and acoustic information for 3D facial performance capture. It generates more accurate 3D mouth motions than other approaches that are based on audio or video input only. It also supports video or audio only input for real-time facial animation. We evaluate the performance of our system with speech and facial expressions captured from different actors. Results demonstrate the efficiency and robustness of our method.
Secondhand Tobacco Smoke Exposure and Lung Adenocarcinoma In Situ/Minimally Invasive Adenocarcinoma (AIS/MIA)
Authors: Kim Claire H. , Lee Yuan-Chin Amy , Hung Rayjean J. , Boffetta Paolo , Xie Dong , Wampfler Jason A. , Cote Michele L. , Chang Shen-Chih , Ugolini Donatella , Neri Monica , Le Marchand Loic , Schwartz Ann G. , Morgenstern Hal , Christiani David C. , Yang Ping , Zhang Zuo-Feng 
Published: October 2015

Abstract
The aim of this study was to estimate the effect of exposure to secondhand tobacco smoke on the incidence of lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA). Data from seven case–control studies participating in the International Lung Cancer Consortium (ILCCO) were pooled, resulting in 625 cases of AIS/MIA and 7,403 controls, of whom 170 cases and 3,035 controls were never smokers. Unconditional logistic regression was used to estimate adjusted ORs (ORadj) and 95% confidence intervals (CI), controlling for age, sex, race, smoking status (ever/never), and pack-years of smoking. Study center was included in the models as a random-effects intercept term. Ever versus never exposure to secondhand tobacco smoke was positively associated with AIS/MIA incidence in all subjects (ORadj = 1.48; 95% CI, 1.14–1.93) and in never smokers (ORadj = 1.45; 95% CI, 1.00–2.12). There was, however, appreciable heterogeneity of ORadj across studies (P = 0.01), and the pooled estimates were largely influenced by one large study (40% of all cases and 30% of all controls). These findings provide weak evidence for an effect of secondhand tobacco smoke exposure on AIS/MIA incidence. Further studies are needed to assess the impact of secondhand tobacco smoke exposure using the newly recommended classification of subtypes of lung adenocarcinoma. Cancer Epidemiol Biomarkers Prev; 24(12); 1902–6. ©2015 AACR.
Pathological T0 Following Cisplatin-Based Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer: A Network Meta-analysis
Authors: Kim Hyung Suk , Jeong Chang Wook , Kwak Cheol , Kim Hyeon Hoe , Ku Ja Hyeon 
Published: October 2015

Abstract
Purpose: To systematically assess and compare the relationship between various neoadjuvant chemotherapy regimens and pCR in patients with muscle-invasive bladder cancer.
Experimental design: We performed a literature search of PubMed, Embase, and the Cochrane Library for all articles published before March 2015 and according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. There were 17 articles that met the study eligibility criteria and were selected for the final analysis. A direct pair-wise meta-analysis was performed for studies that compared the same regimen. Finally, a Bayesian network meta-analysis was used to indirectly compare the regimens.
Results: In a pair-wise meta-analysis, the methotrexate/vinblastine/Adriamycin/cisplatin [MVAC; OR, 4.36; 95% confidence interval (CI), 2.71–7.02] and gemcitabine/cisplatin (GC) regimens (OR, 4.92; 95% CI, 2.93–8.24) were significantly associated with a better pCR than RC alone. In a network meta-analysis, there was no significant difference in terms of pCR achievement between the GC and MVAC regimens (OR, 1.14; 95% CI; 0.85–1.70). However, in a subgroup network meta-analysis that only included prospective randomized trials, the MVAC regimen was significantly correlated with a higher rate of pCR (OR, 5.75; 95% CI, 1.96–24.18).
Conclusions: The results of this meta-analysis suggest that a GC regimen was associated with a pCR rate that was similar to that of a MVAC regimen based on retrospective data, but only the MVAC regimen was proven to achieve pCR in prospective randomized trials. Additional prospective randomized trials comparing both regimens will be necessary to establish the optimal neoadjuvant chemotherapy regimen. Clin Cancer Res; 22(5); 1086–94. ©2015 AACR.
Projeto CÃOCER: uma Abordagem Educativa para a Prevenção de Cânceres em Animais
Authors: Fukumasu Heidge , Dellova Deise Carla Almeida Leite , Strefezzi Ricardo De Francisco , Godoy Demétrio Ian Carvalho de , Kühl Gabriela De Souza , Luz Renato Ordones Baptista da , Garnica Taismara Kustro , Baptista Gabriela Zambelli 
Published: October 2015

<p>O projeto CÃOCER há quatro anos compreende atividades intra e extramurais à USP com a finalidade de conscientizar a população sobre a importância dos cânceres em animais, focando em sua prevenção. Foram realizados ciclos de palestras para alunos de graduação em Medicina Veterinária e profissionais. Participamos de feiras de ciência e exposições para divulgação à população de Pirassununga, e realizamos a I Cãopanha de Prevenção de Câncer em Animais em que foram feitos exames clínicos nos animais e distribuído material educativo referente à prevenção de câncer. Por fim, ainda objetivou-se realizar um levantamento estatístico da casuística de animais portadores de neoplasias atendidos no Hospital Veterinário da FMVZ no campus de Pirassununga da USP. Colaboraram com este projeto diversos alunos de graduação em Medicina Veterinária da FZEA-USP e alunos do ensino médio que obtiveram bolsas pelo Programa de Pré-Iniciação Científica da USP. Passados quatro anos desde<br />seu início, o projeto atingiu seus objetivos iniciais e agora o intuito é expandi-lo. Para isso criamos um site (www.projetocaocer.com.br) que disponibiliza artigos sobre<br />prevenção do câncer em animais. Pretendemos, também, aumentar as atividades extensionistas do projeto, junto à Associação Brasileira de Oncologia Veterinária e ao NAP de Oncologia Veterinária da Pró-Reitoria de Pesquisa da USP.</p>
Risk Prediction in Aortic Valve Replacement: Incremental Value of the Preoperative Echocardiogram
Authors: Tan Timothy C. , Flynn Aidan W. , Chen‐Tournoux Annabel , Rudski Lawrence G. , Mehrotra Praveen , Nunes Maria C. , Rincon Luis M. , Shahian David M. , Picard Michael H. , Afilalo Jonathan 
Published: October 2015

Background

Risk prediction is a critical step in patient selection for aortic valve replacement (
AVR
), yet existing risk scores incorporate very few echocardiographic parameters. We sought to evaluate the incremental predictive value of a complete echocardiogram to identify high‐risk surgical candidates before
AVR
.

Methods and Results

A cohort of patients with severe aortic stenosis undergoing surgical
AVR
with or without coronary bypass was assembled at 2 tertiary centers. Preoperative echocardiograms were reviewed by independent observers to quantify chamber size/function and valve function. Patient databases were queried to extract clinical data. The cohort consisted of 432 patients with a mean age of 73.5 years and 38.7% females. Multivariable logistic regression revealed 3 echocardiographic predictors of in‐hospital mortality or major morbidity: E/e’ ratio reflective of elevated left ventricular (LV) filling pressure; myocardial performance index reflective of
right ventricular (RV)
dysfunction; and small LV end‐diastolic cavity size. Addition of these echocardiographic parameters to the
STS
risk score led to an integrated discrimination improvement of 4.1% (
P
<0.0001). After a median follow‐up of 2 years, Cox regression revealed 5 echocardiographic predictors of all‐cause mortality: small
LV
end‐diastolic cavity size;
LV
mass index; mitral regurgitation grade; right atrial area index; and mean aortic gradient <40 mm Hg.

Conclusions

Echocardiographic measures of
LV
diastolic dysfunction and RV performance add incremental value to the
STS
risk score and should be integrated in prediction when evaluating the risk of
AVR
. In addition, findings of small hypertrophied
LV
cavities and/or low mean aortic gradients confer a higher risk of 2‐year mortality.
Oxylipid Profile of Low‐Dose Aspirin Exposure: A Pharmacometabolomics Study
Authors: Ellero‐Simatos Sandrine , Beitelshees Amber L. , Lewis Joshua P. , Yerges‐Armstrong Laura M. , Georgiades Anastasia , Dane Adrie , Harms Amy C. , Strassburg Katrin , Guled Faisa , Hendriks Margriet M. W. B. , Horenstein Richard B. , Shuldiner Alan R. , Hankemeier Thomas , Kaddurah‐Daouk Rima ,   Pharmacometabolomics Research Network
Published: October 2015

Background
While aspirin is a well‐established and generally effective anti‐platelet agent, considerable inter‐individual variation in drug response exists, for which mechanisms are not completely understood. Metabolomics allows for extensive measurement of small molecules in biological samples, enabling detailed mapping of pathways involved in drug response.

Methods and Results

We used a mass‐spectrometry‐based metabolomics platform to investigate the changes in the serum oxylipid metabolome induced by an aspirin intervention (14 days, 81 mg/day) in healthy subjects (n=156). We observed a global decrease in serum oxylipids in response to aspirin (25 metabolites decreased out of 30 measured) regardless of sex. This decrease was concomitant with a significant decrease in serum linoleic acid levels (−19%,
P
=1.3×10
−5
), one of the main precursors for oxylipid synthesis. Interestingly, several linoleic acid‐derived oxylipids were not significantly associated with arachidonic‐induced ex vivo platelet aggregation, a widely accepted marker of aspirin response, but were significantly correlated with platelet reactivity in response to collagen.

Conclusions

Together, these results suggest that linoleic acid‐derived oxylipids may contribute to the non‐
COX
1 mediated variability in response to aspirin. Pharmacometabolomics allowed for more comprehensive interrogation of mechanisms of action of low dose aspirin and of variation in aspirin response.
Operational Wave Prediction System at Environment Canada: Going Global to Improve Regional Forecast Skill
Authors: Bernier Natacha B. , Alves Jose-Henrique G. M. , Tolman Hendrik , Chawla Arun , Peel Syd , Pouliot Benoit , Bélanger Jean-Marc , Pellerin Pierre , Lépine Mario , Roch Michel 
Published: October 2015

Abstract
A global deterministic wave prediction system (GDWPS) is used to improve regional forecasts of waves off the Canadian coastline and help support the practice of safe marine activities in Canadian waters. The wave model has a grid spacing of ¼° with spectral resolution of 36 frequency bins and 36 directional bins. The wave model is driven with hourly 10-m winds generated by the operational global atmospheric prediction system. Ice conditions are updated every three hours using the ice concentration forecasts generated by the Global Ice–Ocean Prediction System. Wave forecasts are evaluated over two periods from 15 August to 31 October 2014 and from 15 December 2014 to 28 February 2015, as well as over select cases during the fall of 2012. The global system is shown to improve wave forecast skill over regions where forecasts were previously produced using limited-area models only. The usefulness of a global expansion is demonstrated for large swell events affecting the northeast Pacific. The first validation of a Canadian operational wave forecast system in the Arctic is presented. Improvements in the representation of forecast wave fields associated with tropical cyclones are also demonstrated. Finally, the GDWPS is shown to result in gains of at least 12 h of lead time.
Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers
Authors: Côté Mathieu , Trudel Mathieu , Wang Changshu , Fortin André 
Published: October 2015

Objectives: Patients treated for head and neck carcinomas experience a significant deterioration of their quality of life during treatments because of severe side effects. Nabilone has many properties that could alleviate symptoms caused by radiotherapy and improve patients’ quality of life. The aim of the present study was to compare the effects of nabilone versus placebo on the quality of life and side effects during radiotherapy for head and neck carcinomas. Methods: Fifty-six patients were randomized to nabilone or placebo. Patients filled the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-H&N35; three independent questionnaires assessing appetite, nausea, and toxicity; and a visual analog scale for pain. These data were collected before radiotherapy, each week during radiotherapy, and 4 weeks after radiotherapy. Patients were weighed every week. Results: Nabilone did not lengthen the time necessary for a 15% deterioration of quality of life ( P = .4279), and it was not better than placebo for relieving symptoms like pain ( P = .6048), nausea ( P = .7105), loss of appetite ( P = .3295), weight ( P = .1454), mood ( P = .3214), and sleep ( P = .4438). Conclusion: At the dosage used, nabilone was not potent enough to improve the patients’ quality of life over placebo.
Intermittent High-Dose Intravenous Interferon Alfa-2b for Adjuvant Treatment of Stage III Melanoma: Final Analysis of a Randomized Phase III Dermatologic Cooperative Oncology Group Trial
Authors: Mohr Peter , Hauschild Axel , Trefzer Uwe , Enk Alexander , Tilgen Wolfgang , Loquai Carmen , Gogas Helen , Haalck Thomas , Koller Josef , Dummer Reinhard , Gutzmer Ralf , Brockmeyer Norbert , Hölzle Erhard , Sunderkötter Cord , Mauch Cornelia , Stein Annette , Schneider Lars A. , Podda Maurizio , Göppner Daniela , Schadendorf Dirk , Weichenthal Michael 
Published: October 2015

PurposeTo evaluate the efficacy, safety, tolerability, and quality of life (QoL) in patients receiving intravenous, intermittent high-dose interferon alfa-2b (IFN-α-2b [iHDI]) compared with standard high-dose IFN-α-2b (HDI).Patient and MethodsPatients with stage III resected lymph node or in-transit metastasis from cutaneous malignant melanoma were randomly assigned to receive either a standard HDI regimen or three courses of IFN-α-2b 20 MIU/m2administered intravenously 5 days a week for 4 weeks then repeated every 4 months. Distant metastasis-free survival was the primary end point for efficacy analysis. In addition, relapse-free survival, overall survival, safety as determined by Common Terminology Criteria for Adverse Events criteria, and QoL were secondary end points.ResultsOf 649 patients enrolled, 22 patients were excluded from the intent-to-treat analysis. The remaining 627 patients were well balanced between the arms according to sex, age, and stage. After a median follow-up of 55 months, a multivariable Cox model revealed no significant differences for distant metastasis-free survival (hazard ratio [HR], 1.21; P = .12) or overall survival (HR, 1.01; P = .85). In contrast, the difference for relapse-free survival was significant (HR, 1.27; P = .03), favoring standard HDI. Early termination of treatment because of adverse events or QoL occurred significantly more often with HDI than with iHDI (26.0% v 14.8%; P < .001).ConclusionAlthough the safety and QoL profiles for the intermittent regimen were favorable, no significant difference was observed for survival while the HR for relapse with iHDI was increased. Therefore, an iHDI regimen, as tested here, cannot be recommended as adjuvant treatment for high-risk melanoma.
Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells
Authors: El-Gohary Yousef , Wiersch John , Tulachan Sidhartha , Xiao Xiangwei , Guo Ping , Rymer Christopher , Fischbach Shane , Prasadan Krishna , Shiota Chiyo , Gaffar Iljana , Song Zewen , Galambos Csaba , Esni Farzad , Gittes George K. 
Published: October 2015

AbstractA key question in diabetes research is whether new β-cells can be derived from endogenous, nonendocrine cells. The potential for pancreatic ductal cells to convert into β-cells is a highly debated issue. To date, it remains unclear what anatomical process would result in duct-derived cells coming to exist within preexisting islets. We used a whole-mount technique to directly visualize the pancreatic ductal network in young wild-type mice, young humans, and wild-type and transgenic mice after partial pancreatectomy. Pancreatic ductal networks, originating from the main ductal tree, were found to reside deep within islets in young mice and humans but not in mature mice or humans. These networks were also not present in normal adult mice after partial pancreatectomy, but TGF-β receptor mutant mice demonstrated formation of these intraislet duct structures after partial pancreatectomy. Genetic and viral lineage tracings were used to determine whether endocrine cells were derived from pancreatic ducts. Lineage tracing confirmed that pancreatic ductal cells can typically convert into new β-cells in normal young developing mice as well as in adult TGF-β signaling mutant mice after partial pancreatectomy. Here the direct visual evidence of ducts growing into islets, along with lineage tracing, not only represents strong evidence for duct cells giving rise to β-cells in the postnatal pancreas but also importantly implicates TGF-β signaling in this process.
Bugs, genes, fatty acids, and serotonin: Unraveling inflammatory bowel disease?
Authors: Kaunitz Jonathan D. , Nayyar Piyush 
Published: October 2015

The annual incidence of the inflammatory bowel diseases (IBDs) ulcerative colitis and Crohn’s disease has increased at an alarming rate. Although the specific pathophysiology underlying IBD continues to be elusive, it is hypothesized that IBD results from an aberrant and persistent immune response directed against microbes or their products in the gut, facilitated by the genetic susceptibility of the host and intrinsic alterations in mucosal barrier function. In this review, we will describe advances in the understanding of how the interaction of host genetics and the intestinal microbiome contribute to the pathogenesis of IBD, with a focus on bacterial metabolites such as short chain fatty acids (SCFAs) as possible key signaling molecules. In particular, we will describe alterations of the intestinal microbiota in IBD, focusing on how genetic loci affect the gut microbial phylogenetic distribution and the production of their major microbial metabolic product, SCFAs. We then describe how enteroendocrine cells and myenteric nerves express SCFA receptors that integrate networks such as the cholinergic and serotonergic neural systems and the glucagon-like peptide hormonal pathway, to modulate gut inflammation, permeability, and growth as part of an integrated model of IBD pathogenesis. Through this integrative approach, we hope that novel hypotheses will emerge that will be tested in reductionist, hypothesis-driven studies in order to examine the interrelationship of these systems in the hope of better understanding IBD pathogenesis and to inform novel therapies.
Prognostic Significance of High-Sensitivity Cardiac Troponin T Concentrations between the Limit of Blank and Limit of Detection in Community-Dwelling Adults: A Metaanalysis
Authors: Parikh Ravi H , Seliger Stephen L , de Lemos James , Nambi Vijay , Christenson Robert , Ayers Colby , Sun Wensheng , Gottdiener John S , Kuller Lewis H , Ballantyne Christie , deFilippi Christopher R 
Published: October 2015

Abstract

BACKGROUND
There is controversy regarding whether to report concentrations of high-sensitivity cardiac troponin T (hs-cTnT) to the limit of blank (LOB) (3 ng/L) or the limit of detection (LOD) (5 ng/L) of the assay in community-based cohorts. We hypothesized that hs-cTnT concentrations between the LOB and LOD would be associated with poorer cardiovascular outcomes compared to concentrations below the LOB.

METHODS
hs-cTnT was analyzed in a total of 10 723 participants from the Cardiovascular Health Study (CHS), Atherosclerosis Risk in Communities (ARIC) study, and Dallas Heart Study (DHS). Participants were divided into 2 groups, those with hs-cTnT concentrations below the limit of blank (LOB) (&lt;3 ng/L) and those with hs-cTnT between the LOB and limit of detection (LOD) (3–4.99 ng/L). Cross-sectional associations with traditional cardiovascular risk factors and cardiac structural measurements, and longitudinal associations with long-term cardiovascular outcomes of incident heart failure and cardiovascular death, were determined.

RESULTS
Participants with hs-cTnT between the LOB and LOD for all 3 cohorts were older, more likely to be male, and have a higher burden of cardiovascular risk factors and structural pathology. A metaanalysis of the 3 cohorts showed participants with hs-cTnT between the LOB and LOD were at increased risk of new-onset heart failure (hazard ratio, 1.18; 95% CI, 1.02–1.38) and cardiovascular mortality (hazard ratio, 1.29; 95% CI, 1.06–1.57).

CONCLUSIONS
hs-cTnT concentrations between the LOB and LOD (3–4.99 ng/L) are associated with a higher prevalence of traditional risk factors, more cardiac pathology, and worse outcomes than concentrations below the LOB (&lt;3 ng/L).