bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissecting diazirine photo-reaction mechanism for protein residue-specific cross-linking and distance mapping
Authors: Jiang Yida , Zhang Xinghe , Nie Honggang , Fan Jianxiong , Di Shuangshuang , Fu Hui , Zhang Xiu , Wang Lijuan , Tang Chun 
Published: July 2024

AbstractWhile photo-cross-linking (PXL) with alkyl diazirines can provide stringent distance restraints and offer insights into protein structures, unambiguous identification of cross-linked residues hinders data interpretation to the same level that has been achieved with chemical cross-linking (CXL). We address this challenge by developing an in-line system with systematic modulation of light intensity and irradiation time, which allows for a quantitative evaluation of diazirine photolysis and photo-reaction mechanism. Our results reveal a two-step pathway with mainly sequential generation of diazo and carbene intermediates. Diazo intermediate preferentially targets buried polar residues, many of which are inaccessible with known CXL probes for their limited reactivity. Moreover, we demonstrate that tuning light intensity and duration enhances selectivity towards polar residues by biasing diazo-mediated cross-linking reactions over carbene ones. This mechanistic dissection unlocks the full potential of PXL, paving the way for accurate distance mapping against protein structures and ultimately, unveiling protein dynamic behaviors.
Micromachined structures decoupling Joule heating and electron wind force
Authors: Gu Shaojie , Kimura Yasuhiro , Yan Xinming , Liu Chang , Cui Yi , Ju Yang , Toku Yuhki 
Published: July 2024

AbstractMicrostructural changes in conductive materials induced by electric current treatments, such as electromigration and electroplasticity, are critical in semiconductor and metal processing. However, owing to the inevitable thermal effect (Joule heating), the athermal effect on microstructural modifications remains obscure. This paper presents an approach of utilizing pre-micromachined structures, which obstruct current flow but maintain a thermal history similar to that of the matrix, effectively disentangling the thermal and athermal effects. A duplex stainless-steel material is selected to validate the feasibility of this method. Microstructural characterizations show that the athermal effect, especially the electron wind force (EWF), primarily governs the element diffusion and phase transformation in this study. Moreover, many σ phases (Cr-enriched) are precipitated in the micromachined structures, whereas no precipitation occurred in the matrix, suggesting that the directional EWF disrupts the Cr aggregation caused by Joule heating. Furthermore, we present a critical formula for determining the dimensions of micromachined structures of commonly used metallic materials. The proposed method may serve as an effective and powerful tool for unveiling the athermal effect on microstructural alterations.
Inverse mapping of quantum properties to structures for chemical space of small organic molecules
Authors: Fallani Alessio , Medrano Sandonas Leonardo , Tkatchenko Alexandre 
Published: July 2024

AbstractComputer-driven molecular design combines the principles of chemistry, physics, and artificial intelligence to identify chemical compounds with tailored properties. While quantum-mechanical (QM) methods, coupled with machine learning, already offer a direct mapping from 3D molecular structures to their properties, effective methodologies for the inverse mapping in chemical space remain elusive. We address this challenge by demonstrating the possibility of parametrizing a chemical space with a finite set of QM properties. Our proof-of-concept implementation achieves an approximate property-to-structure mapping, the QIM model (which stands for “Quantum Inverse Mapping”), by forcing a variational auto-encoder with a property encoder to obtain a common internal representation for both structures and properties. After validating this mapping for small drug-like molecules, we illustrate its capabilities with an explainability study as well as by the generation of de novo molecular structures with targeted properties and transition pathways between conformational isomers. Our findings thus provide a proof-of-principle demonstration aiming to enable the inverse property-to-structure design in diverse chemical spaces.
How shared suffering bonded Britons witnessing the Queen’s funeral
Authors: White Claire , Morales Danielle , Xygalatas Dimitris , Hernu Mathilde , Mathiassen Anna , Ainsworth Andrew , Geraty Meara , Bayindir Nisa , Robinson Brooke , Whitehouse Harvey 
Published: July 2024

AbstractPrevious research suggests that sharing emotionally intense experiences with others, for example by undergoing dysphoric collective rituals together, can lead to “identity fusion,” a visceral feeling of oneness that predicts group cohesion and self-sacrifice for the group. In this pre-registered research, we provide the first quantitative investigation of identity fusion following participation in a national funeral, surveying 1632 members of the British public. As predicted, individuals reporting intense sadness during Queen Elizabeth II’s funeral exhibited higher levels of identity fusion and pro-group commitment, as evidenced by generosity pledges to a British Monarchist charity. Also consistent with our hypotheses, feelings of unity in grief and emotional sharedness during the event mediated the relationship between sadness intensity and pro-group commitment. These findings shed light on importance of collective rituals in fostering group cohesion, cooperation, and the dynamics of shared emotional experiences within communities.
Transcriptome profiling reveals dysregulation of inflammatory and protein synthesis genes in PCOS
Authors: Li Xilian , Gao Biao , Gao Bingsi , Li Xin , Xia Xian 
Published: July 2024

AbstractTo analyze the differential expression genes of polycystic ovary syndrome (PCOS), clarify their functions and pathways, as well as the protein–protein interaction network, identify HUB genes, and explore the pathological mechanism. PCOS microarray datasets were screened from the GEO database. Common differentially expressed genes (co-DEGs) were obtained using GEO2R and Venn analysis. Enrichment and pathway analyses were conducted using the DAVID online tool, with results presented in bubble charts. Protein–protein interaction analysis was performed using the STRING tool. HUB genes were identified using Cytoscape software and further interpreted with the assistance of the GeneCards database. A total of two sets of co-DEGs (108 and 102), key proteins (15 and 55), and hub genes (10 and 10) were obtained. The co-DEGs: (1) regulated inflammatory responses and extracellular matrix, TNF, and IL-17 signaling pathways; (2) regulated ribosomes and protein translation, ribosome and immune pathways. The key proteins: (1) regulated inflammation, immunity, transcription, matrix metabolism, proliferation/differentiation, energy, and repair; (2) regulated ubiquitination, enzymes, companion proteins, respiratory chain components, and fusion proteins. The Hub genes: (1) encoded transcription factors and cytokines, playing vital roles in development and proliferation; (2) encoded ribosomes and protein synthesis, influencing hormone and protein synthesis, associated with development and infertility. The dysregulated expression of inflammation and protein synthesis genes in PCOS may be the key mechanism underlying its onset and progression.
A multi-center analysis of visual outcomes following open globe injury
Authors: Greenfield Jason A. , Malek Davina A. , Anant Shruti , Antonietti Michael , Jammal Alessandro , Casella Alicia , Miller Sarah C. , Wang Kristine , Momenaei Bita , Lee Karen , Mansour Hana A. , Justin Grant A. , Makhoul Kevin G. , Bitar Racquel A. , Lorch Alice C. , Armstrong Grayson W. , Wakabayashi Taku , Yonekawa Yoshihiro , Woreta Fasika , Cavuoto Kara 
Published: July 2024

AbstractThe purpose of this study was to examine how demographics, etiology, and clinical examination findings are related to visual outcomes in subjects with open globe injury (OGI) across a large and generalizable sample. A retrospective cohort analysis was performed using data collected from the electronic medical records of four tertiary university centers for subjects with OGI presenting from 2018 to 2021. Demographic information, injury mechanisms, clinical exam findings, visual acuity (VA) at presentation and most recent follow-up were recorded. In subjects with bilateral OGIs, only right eyes were included. A modified ocular trauma score (OTS) using presenting VA, the presence of perforating injury, OGI, and afferent pupillary defect was calculated. The risk of subjects’ demographic characteristics, ocular trauma etiology, clinical findings and modified OTS on the presence of monocular blindness at follow-up were assessed using univariable and multivariable regression models. 1426 eyes were identified. The mean age was 48.3 years (SD: ± 22.4 years) and the majority of subjects were men (N = 1069, 75.0%). Univariable analysis demonstrated that subjects of Black race were 66% (OR: 1.66 [1.25–2.20]; P < 0.001) more likely to have monocular blindness relative to White race at follow-up. OTS Class 1 was the strongest predictor of blindness (OR: 38.35 [21.33–68.93]; P < 0.001). Based on multivariable analysis, lower OTS category (OTS Class 1 OR: 23.88 [16.44–45.85]; P < 0.001) moderately predicted visual outcomes (R2 = 0.275, P < 0.001). OGI has many risks of poor visual outcome across patient groups that vary by demographic category, mechanism of injury, and clinical presentation. Our findings validate that a modified OTS remains a strong predictor of visual prognosis following OGI in a large and generalizable sample.
Treatment of IDH-mutant glioma in the INDIGO era
Authors: Lin Mathew D. , Tsai Alexander C.-Y. , Abdullah Kalil G. , McBrayer Samuel K. , Shi Diana D. 
Published: July 2024

AbstractGliomas are the most common primary brain tumor and are uniformly lethal. Despite significant advancements in understanding the genetic landscape of gliomas, standard-of-care has remained largely unchanged. Subsets of gliomas are defined by gain-of-function mutations in the metabolic genes encoding isocitrate dehydrogenase (IDH). Efforts to exploit mutant IDH activity and/or directly inhibit it with mutant IDH inhibitors have been the focus of over a decade of research. The recently published INDIGO trial, demonstrating the benefit of the mutant IDH inhibitor vorasidenib in patients with low-grade IDH-mutant gliomas, introduces a new era of precision medicine in brain tumors that is poised to change standard-of-care. In this review, we highlight and contextualize the results of the INDIGO trial and introduce key questions whose answers will guide how mutant IDH inhibitors may be used in the clinic. We discuss possible combination therapies with mutant IDH inhibition and future directions for clinical and translational research.
Shared Book Reading Experiences for Young Children Who Use Augmentative and Alternative Communication Systems
Authors: Wence Braelyn , Lorio Ciera , Yacucci Amy 
Published: July 2024

Purpose:
Shared book reading (SBR) is an evidence-based literacy activity that promotes the development of oral language and emergent literacy skills in young children; however, literature regarding best practices for parents of children with developmental disabilities under the age of 5 years, specifically those with complex communication needs, is severely limited. In this descriptive study, we aimed to better understand how families of toddlers/preschoolers incorporated augmentative and alternative communication (AAC) into SBR interactions.

Method:
Videos of SBR interactions were collected across five families with children between 35 and 48 months of age who used AAC systems. Three families had previous training in AAC use during SBR; two families did not have previous training and reportedly did not use their child's AAC system during typical SBR interactions at home. Thus, SBR without AAC was considered “typical” for these two families, and behaviors were compared across two conditions: SBR without AAC and SBR with AAC. Each video was coded for a variety of parent and child behaviors, including asking questions, repetitions, modeling/commenting, expanding/extending, defining vocabulary, affirmations, initiations, and responses. The communication modality used was coded for each behavior.

Results:
Analysis of the video coding revealed that parents used a variety of strategies and that children relied on multimodal means of communication during SBR. For the two families who had videos collected across two conditions, namely, SBR without AAC and SBR with AAC, family AAC use increased the overall duration of SBR activities. For all families, the frequency of parent SBR strategy use increased the SBR duration.

Conclusions:
This study adds to the limited research on SBR practices with toddlers/preschoolers who use AAC. Directions for future research and the implications of the study are discussed.

Supplemental Material:

https://doi.org/10.23641/asha.26240408
Dossier : « La recherche au défi de la crise des temporalités » : No Future. Les collectifs néopaysans et leur rapport à l’avenir : utopie, dystopie et présentisme
Authors: Sallustio Madeleine 
Published: July 2024

S’intéresser aux rapports que les individus entretiennent à l’égard du futur et à la façon dont ceux-ci façonnent des états émotionnels (individuels ou collectifs) est utile pour mieux comprendre ce qui motive les pratiques sociales. Cet article propose de s’intéresser aux théories de l’effondrement qui nourrissent l’imaginaire de certains protagonistes du phénomène du « retour à la terre ». Sur la base d’un travail de terrain de longue durée au sein d’une dizaine de collectifs néopaysans dans le Massif central, je mobiliserai le paradigme des temporalités multiples pour nuancer les effets des théories de l’effondrement sur le quotidien des individus. J’argumenterai que les projets visant le repli en monde rural et l’autonomie alimentaire s’inscrivent dans une temporalité présentiste paradoxale qui fait coexister des horizons temporels antinomiques, à la fois pessimistes et optimistes, vis-à-vis de l’avenir et de la lutte sociale. Le refus des acteurs d’adhérer aux grands récits linéaires et d’un mode de lutte organisé et cohérent à visée universelle me permettra ici d’alimenter les réflexions 1) sur l’action humaine dans son rapport à la crise environnementale et sociale et 2) sur des fondements épistémologiques plus généraux, relatifs à la manière d’appréhender les temporalités en sciences sociales.
Double Trouble: Malunited Distal Radius Fracture and Scapholunate Ligament Injury
Authors: Golubev Igor O. , Gazimieva Bella M. , Bessonov Dmitry A. , Sautin Maksim E. , Korolev Andrey V. 
Published: July 2024

Abstract
Background Combinations of distal radius fractures with scapholunate ligament (SL) injuries are hard to diagnose, and amalunited fractures with ligament damage are rarely discussed.
Methods Here is presented a case of a 40-year-old man with history of a malunited distal radius fracture and a scapholunate rupture with a time difference of over a decade between assumed traumatic incidents. We present the results of a simultaneous treatment of both conditions with corrective osteotomy and osteosynthesis of the distal radius combined with SL tenodesis.
Results At 2 years after the surgery, there was a significant improvement in the results of the patient's questionnaire on subjective scales, a slight improvement in the range of motion in the wrist joint.
Conclusion Despite the lack of publications on the topic in the literature, isolated problems of malunion of the distal radius fractures and the consequences of scapholunate injuries are still open for discussion. Our results suggest that when these two problems are combined, one-stage treatment can have excellent results.
Management of Diffuse Carcinomatosis of the Bone Marrow from Occult Breast Cancer with Abemaciclib and Letrozole: Case Report and Literature Review
Authors: Makwana Ketan , Valame Shaunak 
Published: July 2024

AbstractOccult breast cancer (OBC) signifies a rare subset of breast cancers, accounting for only 0.3 to 1% of all breast cancers. Diagnosing cancer of unknown primary requires a comprehensive approach, including histological examination, immunohistochemistry, multidisciplinary team assessments, and specialized therapy. We present the case of a postmenopausal woman diagnosed with OBC with diffuse carcinomatosis of the bone marrow (DCBM), which was hormone receptor positive and Her2neu negative. Treatment with aromatase inhibitor and the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor abemaciclib yielded significant clinical improvement. The full potential of this therapy warrants investigation in real-world studies.
Influence of laser power and beam path under nonuniform AC electric fields on 3D microvortex flow
Authors: Park Choongbae , Wereley Steven T 
Published: July 2024

Abstract
This paper describes the effect of optical light on the generation and manipulation of microvortex flow named ‘twin opposing microvortex’ (TOMV) flow. This opto-electrohydrodynamic (OEHD) technique combines optical light, i.e. infrared (IR) laser (1064 nm), with non-uniform AC electric fields generated from a pair of indium tin oxide (ITO) electrodes. When the IR laser beam passes through the electric fields, a rapid and three-dimensional (3D) vortex flow is generated in a microchamber. When the laser beam passes through the electric fields, especially the exposed ITO electrode, the direction of the TOMV flow as well as its strength are controlled. With an AC signal of 107 kHz and various voltages below a peak-to-peak voltage of 10 V, laser power is varied up to 1.5 W and the path of a laser beam relative to the electrode (300 μm long and 16 μm wide) is manipulated. The maximum in-plane velocity outside the electrode region was obtained by micron-resolution particle image velocimetry (μPIV). When the laser beam passes through the left or right side of the lower electrode, the TOMV flow field rotates counterclockwise or clockwise, respectively. Applying optical light on an ITO electrode creates in situ and on-demand microvortex flow, which increases the feasibility of OEHD technique in various biological and chemical applications (e.g., mixing and delivering nanofluids in microfluidic devices).
Characterization of the periodic dissociation process of the NaI molecule
Authors: Gao Wei , Ren Lu-Lu , Jing Su-Hua , Han Yong-Chang 
Published: July 2024

Abstract
A theoretical model is proposed to illustrate the periodic dissociation process of NaI molecule. The kinetic energy release (KER) of the fragments is obtained from the theoretical analysis and the quantum wave packet simulation, respectively. It is found that the theoretical model can predict the periodic dissociation results with four parameters, which are expansion coefficient of the eigenstates c

E
, attenuation factor of the dissociating wave packets

α

, the vibrational period of the excited state τ

e
and the time delay τ between the first two dissociation wave packets. The attenuation factor

α

is equal to 1 due to the different photofragments corresponding to the same probability amplitude. Furthermore, the inherent nonadiabatic coupling only causes the population transfer from the excited state to the ground state, without influencing the periodic motion of the wave packet.
Towards optimisation of the chemical composition of a bone-imitating dosimeter as a potential component of multiphase dosimeters
Authors: Jaszczak-Kuligowska M. , Kozicki M. , Maras P. 
Published: July 2024

Abstract
The paper concerns a bone-imitating dosimeter called BoneGel (PAGAT2–Pluronic F–127 with hydroxyapatite). The addition of inorganic salt (MgCl2) to the composition increased the dose sensitivity of the dosimeter.
A characterization of LCV micelle gel dosimeters for boron neutron capture therapy
Authors: Narita Ryosuke , Hayashi Shin-ichiro , Sakurai Yoshinori 
Published: July 2024

Abstract
As a method for three-dimensional quality assurance in boron neutron capture therapy (BNCT), micelle gel dosimeters are focused on. We are investigating dose-component discrimination method by using multiple gel dosimeters which have each different radiation quality specificity. In this study, the characteristics of each gel dosimeter for neutrons and gamma-rays were evaluated, and a dose-component discrimination method was suggested.
Simultaneous comparison of two independent dosimetry verification systems for VMAT irradiation in assessing 4D dose distribution
Authors: Krauleidis Aurimas , Adlienė Diana 
Published: July 2024

Abstract
Despite the rapid development of new technologies, 4D dose assessment related to the breathing movement of target organs during radiotherapy treatment is still a challenge. This study aimed to investigate the feasibility of polymer gel dosimeters to assess 4D dose distribution accuracy in VMAT radiotherapy treatment under dynamic conditions and to compare assessment results with the data obtained using a cylindrical water-equivalent phantom with a three-dimensional diode array (ArcCheck). For this purpose, several homemade polymer gels were filled in cylindrical containers and placed within the ArcCheck phantom. The entire system was mounted on rotating wheels and periodically moved by a connected robotic platform during irradiation. Generally, good agreement was found between measurement results of the 4D dose distribution obtained in the bulk of volume using homemade polymer gel dosimeters and diode detector system, indicating the potential to address the remaining small errors in further experiments. The latter implies the applicability of polymer gel dosimeters for the validation of high-dose stereotactic treatment plans under realistic 4D dose distribution conditions.
Characterization of the BOLDPET optical prototype, an innovative Cherenkov detector for 511 keV γ radiation
Authors: Chyzh R. , Tauzin G. , Yvon D. , Sung C.-H. , Breton D. , Maalmi J. , Schäfers K. , Weinheimer C. , Sharyy V. 
Published: July 2024

Abstract
In the present work we describe the design, construction,
and testing of the optical prototype developed for the BOLDPET
project, with the objective of creating a PET detection module with
high spatial and time resolution. The BOLDPET technology uses an
innovative detection liquid, trimethylbismuth, for detecting
511 keV γ-quanta resulting from positron annihilation. The
optical signal is exclusively produced through the Cherenkov
mechanism, and the produced photons are detected using Planacon
microchannel-plate photomultiplier. We achieve an excellent time
resolution of 150 ps (FWHM) within a sizable detection volume
measuring 55 mm× 55 mm× 25 mm.
Through detailed Geant4 simulations, we examine the limiting factors
affecting time resolution and explore potential avenues for
improvement. Furthermore, we demonstrate the feasibility of coarse
2D localization of interactions using the optical signal alone,
achieving a precision of about 5–8 mm (FWHM) within the
homogeneous detection volume.