bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pemberian Telur Rebus dan Madu Terhadap Kadar Haemoglobin Remaja Putri di Posyandu Remaja Raemadia Wilayah Kerja Puskesmas Seba Nusa Tenggara Timur
Authors: Berel Stiesia , Suralaga Cholisah , Lail Nurul Husnul 
Published: July 2024

Masa Remaja (Adolescence) merupakan masa transisi dari kanak-kanak menuju masa dewasa ditandai dengan terjadi perubahan-perubahan baik fisik, psikis dan psikososial. Perubahan fisik yang terjadi pada remaja ditandai dengan pertumbuhan tinggi badan dan berat badan. Sehingga tubuh membutuhkan gizi tinggi karena berhubungan dengan komposisi tubuh, kurangnya zat gizi seperti zat besi pada remaja dapat menimbulkan berbagai macam masalah kesehatan seperti Anemia. Penelitian ini bertujuan untuk mengetahui adanya pengaruh pemberian telur rebus dan madu terhadap kadar hemoglobin remaja putri di Posyandu remaja raemadia wilayah kerja Puskesmas Seba Nusa Tenggara Timur. Desain penelitian ini yaitu quasi eksperimen dengan pre and post test design with control group yaitu melakukan pre test - post test . Populasi pada penelitian adalah 65 remaja putri yang anemia . Tehnik sampel yang digunakan dalam penelitian ini adalah purposive sampling. sampel yang digunakan dalam penelitian ini adalah total sampling yaitu 30 sampel, dan dibagi menjadi 2 yaitu 15 sampel untuk kelompok intervensi dan 15 untuk kelompok kontrol. Dari hasil penelitian didapatkan uji statistic menggunakan uji Independent t-test diperoleh mean pada selisih kelompok intervensi dan selisih kelompok kontrol sebanyak 0,019 gr/dl dan nilai p 0,000 (p <0,05). Dapat disimpulkan bahwa ada pengaruh konsumsi telur rebus dan madu terhadap kadar hemoglobin remaja putri di posyandu remaja raemadia wilayah kerja Puskesmas Seba Nusa Tenggara Timur.
Review Penggunaan Interval Docetaxel pada Kemoterapi
Authors: Wijayanti Nunuk 
Published: July 2024

Modalitas terapi pada kanker salah satunya dengan kemoterapi. Dosetaksel merupakan salah satu obat sitostatika yang digunakan pada kemoterapi berbagai jenis kanker. Dosetaksel dapat digunakakan dalam regimen tunggal maupun kombinasi dan dapat diberikan dalam berbagai interval baik mingguan atau interval 3 minggu. Pada kemoterapi kanker payudara, docetaxel sebagai rejimen tunggal diberikan dengan dosis 60-100 mg/m2. Sedangkan pada interval mingguan dapat diberikan pada dosis dosis 35 mg/m2 selama 3 minggu diikuti dengan 1 minggu istirahat Dosis maksimal penggunaan dosetaksel di Indonesia adalan 100mg/m2. Tidak ada perbedaan secara signifikan terkait efikasi dari adanya perbedaan interval, namun dalam beberapa artikel disebutkan bahwa penggunaan dosetaksel mingguan lebih direkomendasikan pada pasien dengan riwayat toksisitas sebelumnya.
Actinic keratosis and field cancerization: Profile of patients of a dermatology service in the city of Lagarto/SE
Authors: Oliveira Iza Brito de , Oliveira Neto Manoelito Cardoso de , Arrais Sara Lani Regattieri , Santana Fabrício Passos , Carregosa Jamylle Catarina Passos , Nogueira Júnior Osmar Alves , Andrade Luciana Nalone 
Published: July 2024

Objective: to evaluate the epidemiological profile, pattern of sun exposure, protective measures and lesion characteristics of patients with actinic keratosis and field cancerization in the city of Lagarto/SE. Methodology: this is a descriptive, cross-sectional and quantitative study using questionnaires over a period of 12 months. Results: the sample included 127 participants, the majority was female, with light skin phototype, low education, average age of 60 years and occupations more exposed to the sun. Participants tended to expose themselves to the sun during the period with the highest incidence of ultraviolet rays, the majority used mechanical photoprotection measures, but only about half of them used sunscreen. Of the total, 124 participants reported having skin lesions, most for more than 1 year, with associated symptoms and in areas of the body most exposed to the sun. Conclusion: most participants belong to risk groups for actinic keratosis and/or skin cancer, work in occupations exposed to the sun, in addition to being exposed at the most critical times of the day. The use of mechanical photoprotection barriers was superior to the use of sunscreen. The characteristics of the interviewees' skin lesions may indicate a delay in reaching the specialized service, making it important to adjust the local flow to optimize care for this population and ensure their early referral.
O cuidado pré-natal na prevenção da violência obstétrica: Uma revisão integrativa
Authors: Souza Akaciane Mota , Nascimento Davi Leonel Araujo , Souza Deborah Cristina Silva , Gomes Karolyny Dias , Morais Allana Tarcisa Santos , Rabelo Andreia Ferreira de Aragão 
Published: July 2024

Objetivo: Identificar o papel do cuidado pré-natal na prevenção da violência obstétrica em gestantes e puérperas. Métodos: Trata-se de uma revisão integrativa de literatura, a coleta de dados foi realizada em dezembro de 2023 nas quatro bases de dados, sendo elas: PubMed, LILACS, BDENF e SciELO. Foram incluídos estudos primários relacionados ao cuidado pré-natal como forma de prevenção da violência obstétrica em gestantes e puérperas, escritos em idiomas português, inglês e espanhol. Resultados: A pesquisa derivou em 9 artigos adequados para os critérios de inclusão da revisão, que se concentraram na base de dados LILACS (55,56%), seguidos da BDENF (22,22%) e PubMed (22,22%). Identificou-se ações para prevenção da violência obstétrica pelos enfermeiros na atenção primária sobre a percepção e conhecimento de formas de violência obstétrica e orientações sobre os direitos da mulher no pré-natal, parto e pós-parto. Conclusão: Conclui-se que o pré-natal humanizado e qualificado apresenta papel significativo na prevenção da violência obstétrica, permitindo o empoderamento da gestante sobre a assistência ao parto fisiológico e sobre seus direitos na assistência gravídico-puerperal.
The prevalence of gestational diabetes among underweight and normal weight women worldwide: a scoping review
Authors: Gitlin Emily S. , Demetres Michelle , Vaidyanathan Arthi , Palmer Nicole , Lee Hannah , Loureiro Sabrina , Radwan Eman , Tuschman Abigail , Mathad Jyoti , Chebrolu Puja 
Published: July 2024

BackgroundGestational diabetes (GDM) affects nearly 15% of pregnancies worldwide and is increasing globally. While this growth is thought to be primarily from overweight and obesity, normal and underweight women are affected as well, particularly in low and middle-income countries. However, GDM in non-overweight women remains understudied. Thus, we examined the prevalence among normal and underweight women globally.MethodsA comprehensive literature search was performed in Ovid MEDLINE, Ovid EMBASE, and The Cochrane Library. Studies retrieved were screened for eligibility against predefined inclusion/exclusion criteria. Prevalence of GDM among women with normal and underweight body mass index (BMI) was extracted, and average prevalence was calculated globally, by World Health Organization region, and by country. Pregnancy outcomes were described when available.ResultsA total of 145 studies were included. The average global prevalence of GDM among non-overweight women (BMI &lt;25 kg/m2) was 7.3% and among underweight women (BMI &lt;18.5 kg/m2) was 5.0%. GDM prevalence in non-overweight women was highest in Asia (average 12.1%) and lowest in the African region (0.7%). The countries with the highest prevalence were Vietnam (21.1%), Finland (19.8%), Poland (19.3%), Bangladesh (18.65%), and China (17.7%). The average global prevalence of large for gestational age infants (LGA) born to non-overweight women with GDM was 9.9%, which is lower than the average prevalence in the general population with GDM (14%).ConclusionGDM is more common than previously recognized in non-overweight women, particularly in Asia, but also in European countries. Non-overweight women with GDM had lower prevalence of LGA babies compared to prior reported prevalence in all women with GDM, though data on pregnancy outcomes was limited. These findings challenge guidelines that recommend restriction of weight gain for GDM management. Further research on the pathophysiology and complications of GDM in women who are not overweight should be urgently conducted to inform appropriate management guidelines and support optimal pregnancy outcomes.
Elucidating the mechanisms and mitigation strategies for six-phthalate-induced toxicity in male germ cells
Authors: Kim Seok-Man , Kim Yong-Hee , Han Gil Un , Kim Seul Gi , Kim Bang-Jin , Moon Sung-Hwan , Shin Seung Hee , Ryu Buom-Yong 
Published: July 2024

Phthalate esters (PAEs) are primary plasticizers and endocrine-disrupting chemicals (EDCs) that are extensively used in numerous everyday consumer products. Although the adverse effects of single PAEs have been studied, our understanding of the effect of multiple phthalate exposure on male germ cell vitality remains limited. Therefore, this study aimed to investigate the collective effects of a mixture of PAEs (MP) comprising diethyl-, bis (2-ethylhexyl)-, dibutyl-, diisononyl-, diisobutyl-, and benzyl butyl-phthalates in the proportions of 35, 21, 15, 15, 8, and 5%, respectively, on differentiated male germ cells using GC-1 spermatogonia (spg) cells. As a mixture, MP substantially hindered GC-1 spg cell proliferation at 3.13 μg/mL, with a half-maximal inhibitory concentration of 16.9 μg/mL. Treatment with 25 μg/mL MP significantly induced reactive oxygen species generation and promoted apoptosis. Furthermore, MP activated autophagy and suppressed phosphorylation of phosphoinositide 3-kinase, protein kinase B, and mammalian target of rapamycin (mTOR). The triple inhibitor combination treatment comprising parthenolide, N-acetylcysteine, and 3-methyladenine effectively reversed MP-induced GC-1 spg cell proliferation inhibition, mitigated apoptosis and autophagy, and restored mTOR phosphorylation. This study is the first to elucidate the mechanism underlying MP-induced male germ cell toxicity and the restoration of male germ cell proliferation mediated by chemical inhibitors. Therefore, it provides valuable insights into the existing literature by proposing a combinatorial toxicity mitigation strategy to counteract male germ cell toxicity induced by various EDCs exposure.
Clinical course and prognostic factors of Pneumocystis pneumonia with respiratory failure in non-HIV patients
Authors: Li Jun , Mu Xiangdong , Li Haichao , Liu Xinmin 
Published: July 2024

BackgroundCompared with Human Immunodeficiency Virus (HIV) patients, non-HIV patients with Pneumocystis pneumonia (PCP) have more rapid onset, more rapid progression, and higher mortality.ObjectivesTo investigate the predictive value of variables obtained upon hospital admission for in-hospital death and 90-day outcomes in non-HIV-PCP patients with respiratory failure (RF).MethodsThis was a single center retrospective study in a tertiary care institution over 15 years. It included all adults inpatients (≥18 years old) with laboratory confirmed non-HIV-PCP with RF who were discharged or died from Peking University First Hospital between April 1st, 2007 and November 1st, 2022. Epidemiological, clinical, laboratory, imaging and outcome data were collected from patient records.ResultsIn this study, a total of 146 non-HIV-PCP patients with RF were included. There were 57 patients (39%) died during hospitalization, 44 patients (53%) died in Intensive care unit (ICU). A total of 137 patients completed 90 days of follow-up, of which 58 (42.3%) died. The multivariable regression analysis revealed that a CD8+ T cell count &lt;115/μl (P=0.009), bronchoalveolar lavage fluid (BALF)-neutrophil percentage ≥50% (P=0.047), the time from corticosteroids withdrawal to symptom onset ≤5 days (P=0.012), and the time from visit to initiation of sulfonamides ≥2 days (P=0.011) were independent risk factors for in-hospital death. Furthermore, a CD8+ T cell count &lt; 115/μl (P=0.001) and the time from visit to initiation of sulfonamides therapy ≥2 days (P=0.033) was independently associated with 90-day all-cause death.ConclusionsA low CD8+ T cell count in peripheral blood, a high percentage of BALF-neutrophils, a short time from corticosteroids withdrawal to symptom onset, and a long time from visit to initiation of sulfonamides are associated with poor prognosis in non-HIV-PCP patients with RF.
Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study
Authors: Wu Haiyang , Sun Zaijie , Guo Qiang , Li Cheng 
Published: July 2024

IntroductionExtensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on the processes of bone formation. Nonetheless, a notable gap exists in the literature concerning a bibliometric analysis of research trends at the nexus of gastrointestinal microbiota and bone metabolism.MethodsTo address this scholarly void, the present study employs a suite of bibliometric tools including online platforms, CiteSpace and VOSviewer to scrutinize the pertinent literature in the realm of gastrointestinal microbiota and bone metabolism.Results and discussionExamination of the temporal distribution of publications spanning from 2000 to 2023 reveals a discernible upward trajectory in research output, characterized by an average annual growth rate of 19.2%. Notably, China and the United States emerge as primary contributors. Predominant among contributing institutions are Emory University, Harvard University, and the University of California. Pacifici R from Emory University contributed the most research with 15 publications. In the realm of academic journals, Nutrients emerges as the foremost publisher, followed closely by Frontiers in Microbiology and PLOS One. And PLOS One attains the highest average citations of 32.48. Analysis of highly cited papers underscores a burgeoning interest in the therapeutic potential of probiotics or probiotic blends in modulating bone metabolism by augmenting host immune responses. Notably, significant research attention has coalesced around the therapeutic interventions of probiotics, particularly Lactobacillus reuteri, in osteoporosis, as well as the role of gastrointestinal microbiota in the etiology and progression of osteoarthritis. Keyword analysis reveals prevalent terms including gut microbiota, osteoporosis, bone density, probiotics, inflammation, SCFAs, metabolism, osteoarthritis, calcium absorption, obesity, double-blind, prebiotics, mechanisms, postmenopausal women, supplementation, risk factors, oxidative stress, and immune system. Future research endeavors warrant a nuanced exploration of topics such as inflammation, obesity, SCFAs, postmenopausal osteoporosis, skeletal muscle, oxidative stress, double-blind trials, and pathogenic mechanisms. In summary, this study presents a comprehensive bibliometric analysis of global research on the interplay between gastrointestinal microbiota and bone metabolism, offering valuable insights for scholars, particularly nascent researchers, embarking on analogous investigations within this domain.
Ten-year trajectory of coronary artery calcification and risk of cardiovascular outcomes: the Multi-Ethnic Study of Atherosclerosis
Authors: Xie Changming , Luo Dongling , Liu Guodu , Chen Jie , Huang Hui 
Published: July 2024

BackgroundWhether and how coronary artery calcium (CAC) progress contributes to cardiovascular outcomes has not been fully elucidated. The aim of this study was to identify different patterns of CAC change and evaluate the associations with different cardiovascular outcomes.MethodsData from the Multi-Ethnic Study of Atherosclerosis study were analyzed. Participants with at least three CT measurements were included. The main study outcome is hard cardiovascular disease (CVD). CAC scores were determined as phantom-adjusted Agatston scores. A group-based trajectory model was used to identify latent groups and estimated the hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional regression models.ResultsA total of 3,616 participants were finally enrolled [mean age 60.55 (SD 9.54) years, 47.76% men and 39.30% Caucasian]. Four distinct trajectories in CAC were identified: class 1, low-stable (24.17%); class 2, low-increasing (27.60%); class 3, moderate-increasing (30.56%); and class 4, elevated-increasing (17.67%). During 13.58 (SD 2.25) years of follow-up, 291 cases of hard CVD occurred. The event rates of hard CVD per 1,000 person-years were 2.23 (95% CI 1.53–3.25), 4.60 (95% CI 3.60–5.89), 7.67 (95% CI 6.38–9.21) and 10.37 (95% CI 8.41–12.80) for classes 1–4, respectively. Compared to participants assigned to class 1, the full-adjusted HRs of hard CVD for classes 2–4 were 2.10 (95% CI 1.33–3.01), 3.17 (95% CI 2.07–4.87), and 4.30 (95% CI 2.73–6.78), respectively. The graded positive associations with hard CVD were consistently observed in subgroups of age, sex, and race, with the presence or absence of hypertension or diabetes. By analyzing potential risk factors for distinctive CAC trajectories, risk factors for the onset and progression of CAC could possibly differ: age, male sex, history of hypertension, and diabetes are consistently associated with the low-, moderate-, and elevated-increasing trajectories. However, Caucasian race, cigarette smoking, and a higher body mass index was related only to risk of progression but not to incident CAC.ConclusionIn this multi-ethnic population-based cohort, four unique trajectories in CAC change over a 10-year span were identified. These findings signal an underlying high-risk population and may inspire future studies on risk management.
Development of a digital mental health intervention for youth with ADHD: exploring youth perspectives on wants, needs, and barriers
Authors: Storetvedt Maren Helene Rinke , Kahlon Smiti , Berg Karin , Sundfjord Ingeborg Alvheim , Nordgreen Tine 
Published: July 2024

BackgroundAttention deficit hyperactivity disorder (ADHD) is a mental health disorder affecting five to eight percent of children and youth worldwide. Inattention, impulsivity, and hyperactivity are core symptoms, which often leads to comorbid disorders and impairments. Increased prevalence of ADHD among youth requires development of accessible and scalable interventions. Digital interventions for ADHD show promising results for adults, yet insight into youths perspectives and needs from digital ADHD interventions is lacking. This study is set in a person-based approach and explore what youths want and need from a therapist-guided digital intervention for ADHD.MethodsExploratory individual interviews were conducted with youths aged 13–16 years diagnosed with ADHD (N = 16). Participants with an ADHD diagnosis were recruited primarily via social media. The interview guide was based on research, treatment guidelines, and clinical expertise. The study applied reflexive thematic analysis, within a Big Q framework. Codes and themes were generated in Nvivo.ResultsFour main themes and sub-themes were generated: (1) Tailoring the intervention to youths with ADHD (Push the right buttons; Stumbling blocks), (2) Managing ADHD (Planning and Focus; Regulation and Balance; Social interactions), (3) Me and my ADHD (Insight and Understanding; Accept and Normalization), and (4) Balance between support and independence.DiscussionThe findings suggest that youths with ADHD prefer stimulating and interactive treatment and are aversive to overwhelming, passive content. The intervention and therapist should encourage empowerment by supporting the youths autonomy in managing their ADHD. Future research is needed to investigate feasibility for person-based approaches to digital mental health treatments. Furthermore, parent perspectives on digital treatment for youths with ADHD should be investigated.
The impact of cultural capital on school performance
Authors: Nunes Alexandre Chaves , Andrade Josemberg Moura de 
Published: July 2024

IntroductionWe define cultural capital as a set of assets or resources accumulated over a lifetime through relationships and events in the family environment. We analyze cultural capital under two dimensions: static cultural capital (SCC) and relational cultural capital (RCC). The objective of this study was to verify the effect that cultural capital has on students' academic performance.MethodThe research included the participation of 11,795 students who were classified into four levels of cultural capital, in each of the two dimensions: G1–Critical, G2–Low, G3–Medium, and G4–High. Statistical analyses such as ANOVA, Student's t-test and factorial design showed the impact of cultural capital in the combination of the different groups with the subjects of Portuguese and mathematics.ResultsThe results led us to conclude that: (1) cultural capital, in both dimensions, impacts the students' academic performance, both in Portuguese, F(3, 11764) = 9.516, with p &lt; 0.001 and η2 = 0.002, F(3, 11764) = 42.349, with p &lt; 0.001 and η2 = 0.011, and in mathematics, F(3, 11764) = 13,728, with p &lt; 0.001 and η2 = 0.003, and F(3, 11764) = 28.138, with p &lt; 0.001 and η2 = 0.007, and; 2. RCC linearly impacts student performance as SCC is increased, F(9, 11771) = 1.869, with p = 0.052 and η2 = 0.001.Conclusion(1) cultural capital impacts students' academic performance, but most notably in the Portuguese language discipline. (2) The dimensions of cultural capital behave differently and the excess of SCC, without the presence of RCC, impacts the reduction of medium performance. (3) The RCC linearly impacts student performance as the SCC is increased.