bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelminticactivities against Anisakis simplex and Hymenolepis nana ofyakuchinone A from Alpinia oxyphylla
Authors: Lin Rong-Jyh , Yen Chuan-Min , Chou Tzung-Han , Chiang Feng-Yu , Wang Guey-Horng , Tseng Ya-Ping , Wang Lin , Huang Ting-Wei , Wang Hui-Chuan , Chan Leong-Perng , Ding Hsiou-Yu , Liang Chia-Hua 
Published: September 2013

Abstract

Background

Alpinia oxyphylla is a common remedy in traditional Chinese medicine.Yakuchinone A is a major constituent of A. oxyphylla andexhibits anti-inflammatory, antitumor, antibacterial, and gastric protectiveactivities.

Methods
Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells aswell as novel mechanisms for the inhibition of adipocyte differentiation,cestocidal activities against Hymenolepis nana adults, and nematocidalactivities against Anisakis simplex larvae are investigated.

Results
Yakuchinone A presents the ability of the removal of DPPH·andABTS+ free radicals and inhibition of lipid peroxidation.Yakuchinone A suppresses intracellular lipid accumulation during adipocytedifferentiation in 3 T3-L1 cells and the expressions of leptin andperoxisome proliferator-activated receptor γ(PPAR γ). Yakuchinone A induces apoptosis and inhibits cellproliferation in skin cancer cells. The inhibition of cell growth by yakuchinone Ais more significant for non-melanoma skin cancer (NMSC) cells than for melanoma(A375 and B16) and noncancerous (HaCaT and BNLCL2) cells. Treatment BCC cells withyakuchinone A shows down-regulation of Bcl-2, up-regulation of Bax, and anincrease in cleavage poly (ADP-ribose) polymerase (PARP). This suggests thatyakuchinone A induces BCC cells apoptosis through the Bcl-2-mediated signalingpathway. The anthelmintic activities of yakuchinone A for A. simplex arebetter than for H. nana.

Conclusions
In this work, yakuchinone A exhibits antioxidative properties, anti-adipocytedifferentiation, antitumor activity, and anthelmintic activities against A.simplex and H. nana.
Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin
Authors: Hsieh Chen-Hsi , Hou Mei-Ling , Chiang Meng-Hsuan , Tai Hung-Chi , Tien Hui-Ju , Wang Li-Ying , Tsai Tung-Hu , Chen Yu-Jen 
Published: September 2013

Abstract

Background
5-fluorouracil (5-FU) and cisplatin (CDDP) are used to enhance radiotherapy (RT) effect for head and neck (HN) cancers. However, the effect of local RT on systemic chemotherapeutics remains unclear. Here, we evaluated the influence of HN irradiation on the pharmacokinetics (PK) of 5-FU and CDDP in rats as experimental model.

Methods
The radiation dose distributions of HN cancer patients were determined for the low dose areas, which are generously deposited around the target volume. Two Gy and 0.5 Gy RT were selected. Single-fraction radiation was delivered to the HN of Sprague–Dawley rats. 5-FU at 100 mg/kg or CDDP at 5 mg/kg was intravenously infused 24 hours after radiation.

Results
Radiation at 2 Gy reduced the area under the plasma concentration vs. time curve (AUC) of 5-FU and CDDP by 16% and 29% compared to non-irradiated controls, respectively. This was accompanied by incremental total plasma clearance values. Intriguingly, low dose radiation at 0.5 Gy resulted in a similar pharmacokinetic profile, with a 17% and 33% reduction in the AUC of 5-FU and CDDP, respectively. The changes in AUC of bile, which increases with RT, were opposite to AUC of plasma for both drugs.

Conclusions
The local HN RT could modulate systemic PK of 5-FU and CDDP in rats. This unexpected RT-PK phenomena may provide a reference for adjustment of drug administration and is worthy of further investigation.

Trial registration
ClinicalTrials.gov ID NCT01755585 and NCT01609114
Posttraumatic stress disorder and health: a preliminary study of group differences in health and health behaviors
Authors: Godfrey Kathryn M , Lindamer Laurie A , Mostoufi Sheeva , Afari Niloofar 
Published: September 2013

Abstract

Background
Individuals with posttraumatic stress disorder (PTSD) are more likely to undertake harmful health behaviors like substance use. Less is known about the association of PTSD with healthful behaviors such as healthy diet and exercise. The purpose of this study was to examine differences across physical health indicators and health behaviors in individuals with and without PTSD.

Methods
A cross-sectional, case–control study of health indicators and self-reported health behaviors in a community and military veteran sample was used.

Results
Based on a structured psychiatric interview, 25 participants had PTSD, and the remaining 55 without PTSD served as the comparison group. Participants were 40 years old on average and 45% were female. Multivariate analysis of variance analyses revealed that participants with PTSD had significantly higher body mass index (p = 0.004), had more alcohol use (p = 0.007), and reported fewer minutes of vigorous exercise (p = 0.020) than those without PTSD. Chi-square analysis of diet content and eating behavior constructs found that individuals with PTSD ate fewer fruits (p = 0.035) and had more guilt after overeating (p = 0.006).

Conclusions
These findings replicate prior research on the link between PTSD and negative health outcomes and engagement in harmful health behaviors and highlight the need for further examination of the association between PTSD and other health behaviors like diet content, eating behaviors, and exercise.
Plasma metabolomic profiling of dairy cows affected with ketosis using gas chromatography/mass spectrometry
Authors: Zhang Hongyou , Wu Ling , Xu Chuang , Xia Cheng , Sun Lingwei , Shu Shi 
Published: September 2013

Abstract

Background
Ketosis is an important problem for dairy cows` production performance. However, it is still little known about plasma metabolomics details of dairy ketosis.

Results
A gas chromatography/mass spectrometry (GC/MS) technique was used to investigate plasma metabolic differences in cows that had clinical ketosis (CK, n=22), subclinical ketosis (SK, n=32), or were clinically normal controls (NC, n=22). The endogenous plasma metabolome was measured by chemical derivatization followed by GC/MS, which led to the detection of 267 variables. A two-sample t-test of 30, 32, and 13 metabolites showed statistically significant differences between SK and NC, CK and NC, and CK and SK, respectively. Orthogonal signal correction-partial least-square discriminant analysis (OPLS-DA) revealed that the metabolic patterns of both CK and SK were mostly similar, with the exception of a few differences. The development of CK and SK involved disturbances in many metabolic pathways, mainly including fatty acid metabolism, amino acid metabolism, glycolysis, gluconeogenesis, and the pentose phosphate pathway. A diagnostic model arbitrary two groups was constructed using OPLS-DA and receiver–operator characteristic curves (ROC). Multivariate statistical diagnostics yielded the 19 potential biomarkers for SK and NC, 31 for CK and NC, and 8 for CK and SK with area under the curve (AUC) values. Our results showed the potential biomarkers from CK, SK, and NC, including carbohydrates, fatty acids, amino acids, even sitosterol and vitamin E isomers, etc. 2-piperidinecarboxylic acid and cis-9-hexadecenoic acid were closely associated with metabolic perturbations in ketosis as Glc, BHBA and NEFA for dealing with metabolic disturbances of ketosis in clinical practice. However, further research is needed to explain changes of 2,3,4-trihydroxybutyric acid, 3,4-dihydroxybutyric acid, α-aminobutyric acid, methylmalonic acid, sitosterol and α-tocopherol in CK and SK, and to reveal differences between CK and SK.

Conclusion
Our study shows that some new biomarkers of ketosis from plasma may find new metabolic changes to have clinically new utility and significance in diagnosis, prognosis, and prevention of ketosis in the future.
Transcription through enhancers suppresses their activity in Drosophila
Authors: Erokhin Maksim , Davydova Anna , Parshikov Alexander , Studitsky Vasily M , Georgiev Pavel , Chetverina Darya 
Published: September 2013

Abstract

Background
Enhancer elements determine the level of target gene transcription in a tissue-specific manner, providing for individual patterns of gene expression in different cells. Knowledge of the mechanisms controlling enhancer action is crucial for understanding global regulation of transcription. In particular, enhancers are often localized within transcribed regions of the genome. A number of experiments suggest that transcription can have both positive and negative effects on regulatory elements. In this study, we performed direct tests for the effect of transcription on enhancer activity.

Results
Using a transgenic reporter system, we investigated the relationship between the presence of pass-through transcription and the activity of Drosophila enhancers controlling the expression of the white and yellow genes. The results show that transcription from different promoters affects the activity of enhancers, counteracting their ability to activate the target genes. As expected, the presence of a transcriptional terminator between the inhibiting promoter and the affected enhancer strongly reduces the suppression. Moreover, transcription leads to dislodging of the Zeste protein that is responsible for the enhancer-dependent regulation of the white gene, suggesting a 'transcription interference’ mechanism for this regulation.

Conclusions
Our findings suggest a role for pass-through transcription in negative regulation of enhancer activity.
Gene hunting in autoinflammation
Authors: Standing Ariane , Omoyinmi Ebun , Brogan Paul 
Published: September 2013

AbstractSteady progress in our understanding of the genetic basis of autoinflammatory diseases has been made over the past 16 years. Since the discovery of the familial Me diterranean f ev er gene MEFV (also known as marenostrin) in 1997, 18 other genes responsible for monogenic autoinflammatory diseases have been identified to date. The discovery of these genes was made through the utilisation of many genetic mapping techniques, including next generation sequencing platforms. This review article clearly describes the gene hunting approaches, methods of data analysis and the technological platforms used, which has relevance to all those working within the field of gene discovery for Mendelian disorders.
Translation and validation of the German version of the Bournemouth questionnaire for low back pain
Authors: Blum-Fowler Celina , Peterson Cynthia , McChurch Johanna Forrer , Le Clech Yann , Humphreys B Kim 
Published: September 2013

Abstract

Background
Finding the best outcome measures for research and quality assurance purposes in terms of validity, sensitivity to change, length and ease of completion is crucial. The Bournemouth questionnaire for neck pain patients was recently translated and validated into German and found to be more sensitive to change than other commonly used questionnaires. However, the low back pain version is not yet available in German. Therefore the purpose of this study was to translate and validate the Bournemouth Questionnaire (BQ) for low back pain (LBP) into German.

Methods
The translation was done in 4 steps, translated and back-translated by two independent people and adapted and approved by an expert committee. Face validity was then done by 30 people who checked the questionnaire for comprehension. Test-retest reliability (reproducibility) was tested using 30 stable back pain patients. Internal consistency was tested using 108 low back patients. External construct validity, external longitudinal validity and responsiveness was tested against the German versions of the Oswestry Disability Index (ODI) and the SF-36 questionnaire using 108 patients from 5 different chiropractic clinics.

Results
The BQ showed high test-retest reliability (ICC > 0.91) for all items and strong internal consistency (Cronbachs alpha = 0.86 at baseline and 0.94 at 4 weeks).
The BQ demonstrated good external construct and longitudinal construct validity with established measures. The effect sizes of the BQ were high and comparable with established measures.
External construct validity and external longitudinal construct validity showed significant correlation for all 7 scales of the BQ with the relevant scales of the other questionnaires with one exception. External responsiveness results showed higher effect sizes for the BQ items and total score indicating better sensitivity to change than the compared measures.

Conclusion
The BQ for LBP was successfully translated and adapted into German. It was successfully tested for validity, consistency, and responsiveness against the German versions of the ODI and the SF-36. It is shorter, covers more domains than the ODI and is more sensitive to change than the other questionnaires.
Optimum parametric performance characterization of an irreversible gas turbine Brayton cycle
Authors: Abou Al-Sood Maher M , Matrawy Kassem K , Abdel-Rahim Yousef M 
Published: September 2013

Abstract
A general mathematical model is developed to specify the performance of an irreversible gas turbine Brayton cycle incorporating two-stage compressor, two-stage gas turbine, intercooler, reheater, and regenerator with irreversibilities due to finite heat transfer rates and pressure drops. Ranges of operating parameters resulting in optimum performance (i.e., η
I ≥ 38 ≥ η
II ≥ 60%, ECOP ≥ 1.65, x
loss ≤ 0.150 MJ/kg, BWR ≤ 0.525, w
net ≥ 0.300 MJ/kg, and q
add ≤ 0.470 MJ/kg) are determined and discussed using the Monte Carlo method. These operating ranges are minimum cycle temperature ranges between 302 and 315 K, maximum cycle temperature ranges between 1,320 and 1,360 K, maximum cycle pressure ranges between 1.449 and 2.830 MPa, and conductance of the heat exchanger ranges between 20.7 and 29.6 kW/K. Exclusive effect of each of the operating parameters on each of the performance parameters is mathematically given in a general formulation that is applicable regardless of the values of the rest of the operating parameters and under any condition of operation of the cycle.
Feasibility of a supported self-management intervention for relatives of people with recent-onset psychosis: REACT study
Authors: Lobban Fiona , Glentworth David , Chapman Lesley , Wainwright Laura , Postlethwaite Adam , Dunn Graham , Pinfold Vanessa , Larkin Warren , Haddock Gillian 
Published: September 2013

BackgroundRelatives of people with psychosis experience high levels of distress and require support. Family interventions have been shown to be effective in improving outcomes but are difficult to access and not suitable for all relatives.AimsTo assess the feasibility and effectiveness of a supported self-management package for relatives of people with recent-onset psychosis.MethodA randomised controlled trial (n = 103) comparing treatment as usual (TAU) in early intervention services with TAU plus the Relatives' Education And Coping Toolkit (REACT) intervention (trial identifier: ISRCTN69299093).ResultsCompared with TAU only, those receiving the additional REACT intervention showed reduced distress and increased perceived support and perceived ability to cope at 6-month follow-up.ConclusionsThe toolkit is a feasible and potentially effective intervention to improve outcomes for relatives. A larger trial is needed to reliably assess the clinical and cost-effectiveness of REACT, and its impact on longer-term outcomes.
Total somatic symptom score as a predictor of health outcome in somatic symptom disorders
Authors: Tomenson Barbara , Essau Cecilia , Jacobi Frank , Ladwig Karl Heinz , Leiknes Kari Ann , Lieb Roselind , Meinlschmidt Gunther , McBeth John , Rosmalen Judith , Rief Winfried , Sumathipala Athula 
Published: September 2013

BackgroundThe diagnosis of somatisation disorder in DSM-IV was based on ‘medically unexplained’ symptoms, which is unsatisfactory.AimsTo determine the value of a total somatic symptom score as a predictor of health status and healthcare use after adjustment for anxiety, depression and general medical illness.MethodData from nine population-based studies (total n = 28377) were analysed.ResultsIn all cross-sectional analyses total somatic symptom score was associated with health status and healthcare use after adjustment for confounders. In two prospective studies total somatic symptom score predicted subsequent health status. This association appeared stronger than that for medically unexplained symptoms.ConclusionsTotal somatic symptom score provides a predictor of health status and healthcare use over and above the effects of anxiety, depression and general medical illnesses.
Daimones in the Thracian Sea: Mysteries, Iron, and Metaphors
Authors: Blakely Sandra 
Published: September 2013

Abstract The daimones associated with the mystery cult of Samothrace have been interpreted as the distant memory of prehistoric smiths or dismissed from investigation altogether because of their absence from the epigraphic record. Anthropological models of metaphor formation offer a more nuanced approach to understanding their functions in the cult. The daimones’ ethnicity suggests a response to cultural interactions and economic production in the region; their metallurgical skills provided a key metaphor articulating a range of concepts which defined the rites, including secrecy, regional identity, and cosmological speculation.
“Oh, Lord, Give This One a Daimon So That He May No Longer Sin”: The Holy Man and His Daimones in Hagiography
Authors: Kalleres Dayna S. 
Published: September 2013

Abstract This essay examines two hagiographical accounts, each features a Christian holy man performing an unusual, though not aberrant, ritual action: casting a daimon onto or into a person. I argue that the priest Innocent in Palladius’ Lausiac History and Abba Daniel in John Moschus’ Spirituale Pratum acted in accordance with their late antique role as ritual experts and “charismatic ombudsmen” and, thus, they could manipulate power relations between the daimon and human to cleanse, protect and/or punish a human, sinful body. To grasp fully the hagiographers’ explorations of a holy man’s charismata-his power over daimones and what kinds of bodies that creates, I situate these narratives within a particularized context of contemporary and earlier Greek demonologies (Plato, Plutarch and Greek Magical Papyri, especially katadesmoi or binding spells), which reveals variant daimon/human relations through time and the consequential material, moral, and intellectual transformations relevant in these hagiographies.
Loyalty Discounts
Authors: Akgün Uğur , Chioveanu Ioana 
Published: September 2013

Abstract
This article analyses the use of loyalty inducing discounts in vertical supply chains. An upstream supplier and a competitive fringe sell differentiated products to a retailer who has private information about the stochastic demand. We compare the market outcomes, when the supplier uses two-part tariffs (2PT), all-unit quantity discounts (AU), and market-share discounts (MS). We show that the retailer’s risk attitude affects supplier’s preferences over these pricing schemes. When the retailer is risk neutral, it bears all the risk and the three schemes lead to the same outcome. When the retailer is risk averse, a 2PT performs the worst from the supplier’s perspective, but it leads to the highest welfare. For a wide range of parameter values (but not for all), the supplier prefers MS to AU. By limiting the retailer’s product substitution possibilities, MS makes the demand for the manufacturer’s product more inelastic. This reduces the amount (share of total profits) the supplier needs to leave to the retailer for the latter to participate in the scheme.
On the local Bump–Friedberg L-function
Authors: Matringe Nadir 
Published: September 2013

Abstract

Let F be a p-adic field. If π be an irreducible representation of

GL
(
n
,
F
)

${{\rm GL}(n,F)}$

, Bump and Friedberg associated to π an Euler factor

L
(
π
,
𝐵𝐹
,

s
1

,

s
2

)

${L(\pi ,\mathit {BF},s_1,s_2)}$

in [Festschrift in honor of I. I. Piatetski-Shapiro on the occasion of his sixtieth birthday. Part II, Weizmann, Jerusalem (1990), 47–65], that should be equal to

L

(
φ

(
π
)

,

s
1

)

L

(
φ

(
π
)

,

Λ
2

,

s
2

)

${L(\phi (\pi ),s_1)L(\phi (\pi ),\Lambda ^2,s_2)}$

, where

φ
(
π
)

${\phi (\pi )}$

is the Langlands' parameter of π. The main result of this paper is to show that this equality is true when

(

s
1

,

s
2

)

=

(
s
+
1
/
2
,
2
s
)

$(s_1,s_2)=(s+1/2,2s)$

, for
s in ℂ.
To prove this, we classify in terms of distinguished discrete series, generic representations of

GL
(
n
,

F
)

${{\rm GL}(n,\hspace*{-0.56905pt}F)}$

which are

χ
α

${\chi _\alpha }$

-distinguished by the Levi subgroup

GL
(
[
(
n
+
1
)
/
2
]
,

F
)
×
GL
(
[
n
/
2
]
,

F
)

${\rm GL}([(n+1)/2], \hspace*{-0.56905pt}F) \times {\rm GL}([n/2], \hspace*{-0.56905pt}F)$

, for

χ
α

(

g
1

,

g
2

)

=
α

(
det

(

g
1

)

/
det

(

g
2

)

)

${\chi _\alpha (g_1,g_2)=\alpha (\det (g_1)/{\det }(g_2))}$

, where α is a character
of F*
of real part between

-
1
/
2

${-1/2}$

and 1/2.
We then adapt
the technique of [`Derivatives and L-functions for

GL
(
n
)

${\rm GL}(n)$

',
preprint 2011] to reduce the proof of the equality to the case of discrete series. The equality for discrete
series is a consequence of the relation between linear periods and Shalika periods for discrete series, and the main result of [Math. Res. Lett. 19 (2012), no. 4, 785–804].
A decomposition theorem in II1-factors
Authors: Dykema Kenneth , Sukochev Fedor , Zanin Dmitriy 
Published: September 2013

Abstract

Building on results of Haagerup and Schultz, we decompose an arbitrary operator in a diffuse, finite von Neumann algebra
into the sum of a normal operator and an s.o.t.-quasinilpotent operator. We also prove an analogue of Weyl's inequality relating eigenvalues and singular values for operators in a diffuse, finite von Neumann algebra.
Religion and Ecomodernity
Authors: Witoszek Nina 
Published: September 2013

Religion has long stood at the center of debates on the environmental crisis of late modernity. Some have portrayed it as a malade imaginaire, providing divine legitimation for human domination and predatory exploitation of natural resources; others have looked up to it as an inspirational force that is the essential condition of planetary revival. There is an ongoing battle of the books on the salience of religion in the modern world. Some trendy volumes declare that God Is Back (Micklethwait and Wooldridge 2009). Others advert to The End of Faith (Harris 2004, harp the theme of The God Delusion (Dawkins 2006), or claim that God Is Not Great (Hitchens 2007). Both sides provide ample evidence to support their adversarial claims. In much of Canada and Western Europe, where religious establishments have courted or colluded with the state, religion has come to be viewed as the enemy of liberty and modernity. Not so in the United States, where the Jeffersonian separation of religion from politics forced religious leaders to compete for the souls of the faithful—and thus to make Christianity more reconcilable with the agenda of modernity,individualism and capitalist enterprise.