bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical evidence of autologous platelet-rich plasma as treatment in macular holes
Authors: Saa David Paredes , Revelo Victor Andres Florez , Noguera Daniel Andres , Niño Vanessa Rangel 
Published: July 2024

Abstract

Background:
A prospective observational study was conducted with the purpose of evaluating the role of autologous platelet-rich plasma (PRP) in the form of a clot as an adjunct in surgery for the closure of large full-thickness macular holes (>400 μm).

Methodology:
Thirteen patients with a diagnosis of full-thickness macular hole larger than 400 μm, without associated pathologies or previous vitreoretinal surgeries, were selected. Each patient underwent a complete ophthalmological evaluation, including visual acuity (uncorrected or best corrected), optical coherence tomography (OCT Optovue), and in some cases, retinal photographs. On the day of the procedure, blood samples were taken to prepare PRP and form a clot according to institutional protocol. Patients were followed for 1 year with periodic evaluations that included OCT, retinal photographs, and assessments by a retina specialist and optometry.

Results:
Of the 13 patients, 46% (6 cases) had an epiretinal membrane as the triggering factor for the macular hole and 54% (7 cases) had vitreomacular traction. Complete closure of the macular hole was achieved in 92.31% (12 cases) and partial closure in 7.69% (1 case). Postoperative best-corrected visual acuity ranged from 20/30 to 20/200 according to the Snellen chart. No patient experienced a deterioration in visual acuity after the procedure.

Conclusions:
The use of PRP as an adjunct treatment for macular hole surgery in patients without previous vitreoretinal surgeries has proven to be effective in achieving complete or partial closure in a high percentage of cases. Pre-and postoperative changes in visual acuity, hole size, and type of closure provide valuable information on the efficacy of PRP treatment in these patients.
Prevalence of neurofibromatosis type 1 in patients presenting with neurofibromas of the eyelid and orbit
Authors: Kazmarek Elisa Moya , Burnier Victória de Lima , Bergeron Sabrina , Arthurs Bryan , Hadad Christian El , Mansure José João , Burnier Miguel Noel 
Published: July 2024

Abstract

Aims:
This study aimed to demonstrate the prevalence of neurofibromatosis type 1 diagnosis in patients presenting with neurofibromas of eyelid and orbit and the factors associated with this disease.

Materials and Methods:
Charts from patients with pathology reports of neurofibroma of the eyelid and orbit from the MUHC-McGill University Ocular Pathology Laboratory from 2007 to 2022 were reviewed to find information about clinical diagnosis of neurofibromatosis type (NF) 1, sex, age, presence of Lisch nodules, and other findings. The data were analyzed with the Chi-square test and Fisher’s exact test.

Results:
The prevalence of NF1 in patients presenting neurofibromas of the eyelid and orbit was 47.62% in the population studied. All patients with plexiform neurofibromas and all the ones presenting Lisch nodules had an NF1 diagnosis.

Conclusion:
All patients with plexiform neurofibromas of the eyelid or orbit and their relatives should be investigated for NF1. Ophthalmological evaluation is essential for the identification of Lisch nodules since their presence, associated with two neurofibromas are enough to meet the criteria for NF1; therefore, the family of patients with that presentation should be clinically, and if necessary, genetically tested.
Two cases of unilateral pediatric proptosis: A diagnostic challenge
Authors: Tara V. Shruthi , Pallavi M. P. , Thulasidas Mithun 
Published: July 2024

Abstract
Pediatric proptosis often presents with confusing clinical features requiring a systematic approach to avoid diagnostic dilemmas. We present two children of retinoblastoma and congenital uveal malignant melanoma, with late presentation. Through this article, we highlight the importance of systematic clinical examination, appropriate investigations for executing timely treatment, clinical correlation, and the value of histopathologic examination.
Reasons for parental refusal to provide consent in a pediatric randomized controlled trial: Lessons learned
Authors: Pasi Rachna , Babu Thirunavukkarasu Arun 
Published: July 2024

Abstract

BACKGROUND:
Results from randomized controlled trials (RCTs) are considered to have the highest level of evidence. Recruiting children for RCT is challenging and greatly influenced by the perception and decision of parents.

OBJECTIVES:
To find the reasons for refusal to participate in RCT.

DESIGNS:
Questionnaire-based qualitative study.

MATERIALS AND METHODS:
Parents who refused to participate in an RCT were asked to fill out the questionnaire, mentioning the reasons for the refusal.

RESULTS:
A total of 20 (14.8%) participants’ parent out of the 135 participants refused to participate in the trial. The age of participants who refused ranged from 6 weeks to 5 years old. We found that the reasons for refusal were as follows: 60.87% had apprehensions, 21.74% believed that pain pre-prophylaxis was unnecessary or preferred post-vaccination if needed, 8.69% refused because they had not received previous vaccinations, and 8.69% cited time constraints.

CONCLUSION:
Addressing the apprehension of parents in pediatric RCTs is crucial for reducing refusals. Non-placebo RCTs can be considered wherever feasible to address concerns about no drug administration to children.
Social Capital, Culture, and Codes in Higher Education: Bourdieusian and Bernsteinian Philosophical Underpinnings in the South Africa Environment
Authors: Pietersen Doniwen , Tsotetsi Cias , Barnett Emma 
Published: July 2024

Social capital ignored is an “object of political and ideological struggle” created to stifle working-class students in educational spaces. Furthermore, as societal dynamics are constructed in the student-lecturer relationship, this article seeks to evaluate how deliberative democracy in the online higher education space can inspire care through the ongoing dialogue between student and lecturer. This is framed against the Bourdieusian (social capital) and Bernsteinian (social code) framework because both theorists’ work highlights how the dominant class (represented by lecturers) consciously and unconsciously tends to ignore students’ social and cultural capital and codes. This, in turn, leads to a lack of dialogue and care in student-lecturer relationships in higher education. One of this study’s findings is that higher education is aimed to support more middle-class students. The reason for this is that our findings show that lecturers tend not to know what to do with the social habitus of working-class or disadvantaged students. The aforementioned phenomena were foregrounded through Bourdieusian (social capital) and Bernsteinian (social code) model that is situated in the sociological approach, which is interpretive in nature, to explore whether dialogue and care were shown.
Prevalensi Terjadinya Komplikasi pada Ibu Hamil dengan Infeksi Covid-19 Post Sectio Caesarea
Authors: Utami Nadila Rizqi , Herdiyantini Mita , Budiarti Retno , Harnanik Titut 
Published: July 2024

Kehamilan merupakan periode pertumbuhan dan perkembangan janin disertai dengan perubahan fisiologis dan imunologis ibu sehingga lebih rentan mengalami infeksi, termasuk infeksi COVID-19. Kehamilan yang disertai dengan infeksi COVID-19 meningkatkan risiko terjadinya komplikasi terhadap ibu hamil. Penelitian ini bertujuan untuk mengetahui prevalensi terjadinya komplikasi post Section Caesarea pada ibu hamil dengan infeksi COVID-19. Metode pengambilan sampel menggunakan purposive sampling dengan melakukan pengamatan data rekam medis di RSPAL dr. Ramelan Surabaya periode Maret 2020 – Maret 2023. Dari total 100 sampel, terdapat 58 kasus yang terkonfirmasi COVID-19 dengan 8 kasus (32,0%) komplikasi kardiovaskular berupa 6 kasus (75,0%) komplikasi PPH dan 2 kasus (25,0%) komplikasi infeksi luka operasi. Prevalensi komplikasi pada saluran pernapasan didapatkan 13 kasus (52,0%) berupa 9 kasus (69,2%) komplikasi pneumonia dan 4 kasus (30,8%) komplikasi ARDS. Komplikasi sepsis didapatkan 1 kasus (4,0%) dan 3 kasus (12,0%) komplikasi kematian pada ibu. Hasil analisis data mengunakan uji Koefisien Kontingensi menunjukkan nilai p-value = 0,001 (p < α). Terdapat hubungan antara infeksi COVID-19 dengan peningkatan prevalensi terjadinya komplikasi pada ibu hamil dan post Sectio Caesarea. Sehingga dalam penelitian ini didapatkan 25 kasus (43,1%) komplikasi post Sectio Caesarea pada ibu hamil dengan infeksi COVID-19 dan terdapat peningkatan prevalensi terjadinya komplikasi pada ibu hamil dengan infeksi COVID-19 post Sectio Caesarea.
Sintomas audiovestibulares em pacientes com Paquimeningite Hipertrófica Idiopática: revisão sistemática da literatura
Authors: Oliveira Rafaela Silva , Nascimento Eduarda Faria do , Feix Fabiana , Freitas Mariana de Albuquerque de , Ribeiro Amanda Victorya de Oliveira 
Published: July 2024

Introdução: Paquimeningite hipertrófica é uma condição clínica com etiologias variadas, que incluem causas inflamatórias, infecciosas e até neoplásicas. A incidência é rara e atinge o espessamento difuso na camada meníngea dura-máter. Objetivo: O objetivo dessa revisão foi apresentar os artigos publicados na literatura que abordassem os sintomas audiovestibulares nos casos de paquimeningite hipertrófica idiopática. Materiais e métodos: Este artigo de revisão foi elaborado a partir da consulta de artigos científicos de 1997 à novembro de 2021, referenciados na base de dados da Medline/PubMED e SciELO. Resultados e discussão: O diagnóstico é realizado pela avaliação clínica associado aos exames de neuroimagem, como tomografia computadorizada e ressonância magnética, se deve incluir o estudo histopatológico. As manifestações vestibulares são muito raras. A patogênese não é clara. A principal causa da perda auditiva e dos sintomas vestibulares pode ser o aprisionamento do nervo no canal auditivo interno com dano neuronal secundário. Os pacientes apresentavam perda auditiva neurossensorial uni ou bilateral. Nestes casos, o tratamento utilizado foi o corticoide, com melhora em 87,5% dos pacientes. Considerações fianis: A descompressão cirúrgica pode ser uma das opções terapêuticas, se necessário aliada ao uso de imunossupressores para reduzir as sequelas otoneurológicas nesses pacientes.
Morphological characteristics of the cerebral cortex of a mini-pig under conditions of gene therapy after experimental stroke
Authors: Safiullov Z. Z. , Izmailov A. , Markosyan V. A. , Khomyakov A. E. , Boychuk N. V. , Nigmetzyanova M. V. , Siraeva A. R. , Targachev S. S. , Valiullin V. V. , Islamov R. R. , Pospelov V. I. 
Published: July 2024

Aim.To study the effectiveness of preventive gene therapy (within 2 days) and gene therapy in the acute phase (after 4 hours) of ischemic stroke in mini-pigs using an autologous leucoconcentrate (AutoLeuc) enriched with recombinant genes of vascular endothelial growth factor (VEGF165), glial cell line-derived neurotrophic factor (GDNF) and neural cell adhesion molecule 1 (NCAM1), as well as the migration of leukocytes transduced with a chimeric adenoviral vector serotype 5 with fiber 35 serotype (Ad5/F35) and the green fluorescent protein (GFP) genome into immune defense organs.Materials and methods.The experiment was conducted on 8-month-old Vietnamese lop-bellied mini-pigs (n=16). An ischemic stroke was created by occlusion of the distal branches of the left middle cerebral artery and the right common carotid artery. Genetically modified AutoLeuc was administered preventively intravenously 2 days before or in the acute phase 4 hours after stroke modelling; the control group was injected with 30 ml of saline solution. The morphology of the cerebral cortex was assessed using histological methods in the areas bordering the infarction and peri-infarction after 21 days. The migration of genetically modified Ad5/F35-GFP leukocytes into the brain, spleen, and submandibular lymph nodes was studied a week after stroke modelling.Results.In the peri-infarction zone, the content of pyknotic neurons in control animals was higher, while the number of capillaries was lower than in the gene therapy groups. In the latter, neurons had a typical morphology with preserved outgrowths; in the control group, the outgrowths were tortuous and fragmented. Fluorescence microscopy after injection of AutoLeuc with Ad5/F35-GFP revealed GFP-positive cells in the spleen and submandibular lymph nodes.Conclusion.21 days after modeling a stroke in mini-pigs against the background of preventive gene therapy or gene therapy in the acute phase using VEGF165/GDNF/NCAM1 AutoLeuc, greater preservation of neurons and a higher density of capillaries in the peri-infarction zone of ischemic brain damage were established. Leukocytes with Ad5/ F35-GFP were found in the spleen and submandibular lymph nodes.
First observations of the transient luminous event effect on ionospheric Schumann resonance, based on the China Seismo-Electromagnetic Satellite
Authors: Qiu Shican , Wang Zhe , Lu Gaopeng , Zhima Zeren , Soon Willie , Velasco Herrera Victor Manuel , Ju Peng 
Published: July 2024

Abstract. In this study, we focus on the interactions and interrelated effects among the transient luminous events (TLEs) recorded at the Luoding ground station (22.76° N, 111.57° E), the lightning activities observed by the World Wide Lightning Location Network, and the ionospheric electric field deduced from the China Seismo-Electromagnetic Satellite (CSES). The results show that on 25 September 2021, the signal-to-noise ratio of the Schumann resonance at the first mode of 6.5 Hz and the second mode of 13 Hz dropped below 2.5 during the TLEs. A significant enhancement in the energy in extremely low frequencies (ELFs) occurred, and the power spectral density increased substantially. Distinct lightning whistler waves were found in the very low frequency (VLF) band, further indicating that the energy could possibly have been excited by the lightning. Our results suggest that the observations of the electric field from the satellite could possibly be utilised to monitor the lower-atmospheric lightning and its impact on the space environment.
A subgrid method for the linear inertial equations of a compound flood model
Authors: van Ormondt Maarten , Leijnse Tim , de Goede Roel , Nederhoff Kees , van Dongeren Ap 
Published: July 2024

Abstract. Accurate flood risk assessments and early warning systems are needed to protect and prepare people in coastal areas from storms. In order to provide this information efficiently and on time, computational costs need to be kept as low as possible. Reduced-complexity models using linear inertial equations and subgrid approaches have been used previously to achieve this goal. In this paper, for the first time, we developed a subgrid approach for the Linear Inertial Equations (LIE) that account for bed level and friction variations. We implemented this method in the SFINCS model. Pre-processed lookup tables that correlate water levels with hydrodynamic quantities make more precise simulations with lower computational costs possible. These subgrid corrections have undergone validation through a variety of conceptual and real-world application scenarios, including analyses of hurricane hazards and tidal fluctuations. We demonstrate that the subgrid corrections for Linear Inertial Equations significantly improve model accuracy while utilizing the same resolution without subgrid corrections. Moreover, coarser model resolutions with subgrid corrections can provide the same accuracy as finer resolutions without subgrid corrections. Limitations are discussed, for example, when grids do not adequately resolve river meanders, fluxes can be overestimated. Our findings show that subgrid corrections are an invaluable asset for hydrodynamic modelers striving to achieve a balance between accuracy and efficiency.
Long-term Variability and Trends of Agulhas Leakage and its Impacts on the Global Overturning
Authors: Grosselindemann Hendrik , Castruccio Frederic S. , Danabasoglu Gokhan , Biastoch Arne 
Published: July 2024

Abstract. Agulhas Leakage transports warm and salty Indian Ocean waters into the Atlantic Ocean and as such is an important component of the global ocean circulation. These waters are part of the upper limb of the Atlantic Meridional Overturning Circulation (AMOC), and Agulhas Leakage variability has been linked to AMOC variability. Agulhas Leakage is expected to increase under a warming climate due to a southward shift in the South Hemisphere westerlies, which could further influence the AMOC dynamics. This study uses a set of high-resolution pre-industrial control and historical and transient simulations with the Community Earth System Model (CESM) with a nominal horizontal resolution of 0.1° for the ocean and sea-ice and 0.25° for the atmosphere and land. At these resolutions, the model represents the necessary scales to investigate the Agulhas Leakage transport variability and its relation to the AMOC. The simulated Agulhas Leakage transport of 19.7 ± 3 Sv lies well within the observed range of 21.3 ± 4.7 Sv. A positive correlation between the Agulhas Current and the Agulhas Leakage is shown, meaning that an increase of the Agulhas Current transport leads to an increase in Agulhas Leakage. The Agulhas Leakage impacts the strength of the AMOC through Rossby wave dynamics that alter the cross-basin geostrophic balance with a time-lag of 2–3 years. Furthermore, the salt flux associated with the Agulhas Leakage influences AMOC dynamics through the salt-advection feedback by reducing the AMOC’s freshwater transport at 34° S. The Agulhas Leakage transport indeed increases under a warming climate due to strengthened and southward shifting winds. In contrast, the Agulhas Current transport decreases, both due to a decrease in the Indonesian Throughflow as well as the strength of the wind-driven subtropical gyre. The increase in Agulhas Leakage is accompanied by a higher salt flux into the Atlantic Ocean, which suggests a destabilisation of the AMOC by salt-advection-feedback.
Disseminated Tuberculosis with Testes Involvement: An Intriguing Case Report
Authors: Kundu Arnab , Mukherjee Ramanuj , Parichha Ayan , Mukhopadhyay Gouri 
Published: July 2024

Background: Disseminated tuberculosis (TB) is the presence of two or more noncontiguous sites resulting from hematogenous dissemination of Mycobacterium tuberculosis. We report a case of disseminated TB with testicular involvement.
Case: A 21-year-old male patient presented to the outpatient department with bilateral testicular enlargement and tenderness for last six months. It was suspected to be a case of epididymo-orchitis and empirical antimicrobial therapy was initiated. However, ultrasonography findings were inconsistent with epididymo-orchitis. Two weeks later the patient again presented with increased nodularity in the right testes. Non-seminomatous germ cell tumor was suspected. However, tumor markers came back normal. Magnetic resonance imaging revealed enlarged lymph nodes in the right inguinal and retroperitoneal region raising a suspicion of testicular lymphoma. Positron emission tomography with computed tomography showed multiple lymphadenopathies. Histopathology of the left axillary lymph node finally confirmed the diagnosis to be tuberculosis. No drug resistance were found and the patient responded well to anti-tubercular drugs.
Conclusion: Diagnosing disseminated TB is difficult as it mimics conditions, such as infarction, cancer, torsion, etc. Attention to small details is necessary. We faced a similar situation in our patient. The patient went through a myriad of tests before finally being diagnosed with TB. Histopathological study was able to get it whereas cytology could not. Similar and totally opposite cases were found in the literature. This highlights the difficulty and importance of these type of cases.
Capacidad predictiva de los indicadores de desequilibrios en los precios inmobiliarios residenciales
Authors: Cáceres Esther 
Published: July 2024

Motivación
El Banco de España utiliza regularmente indicadores para medir los desequilibrios que se producen en los precios del sector inmobiliario residencial y tomar decisiones trimestrales sobre el colchón de capital anticíclico. Este artículo analiza la capacidad predictiva de crisis sistémicas de esos indicadores.
Ideas principales
•El sector inmobiliario residencial es especialmente importante para la estabilidad financiera, como puso de manifiesto la crisis inmobiliaria que experimentó España a partir de 2008, por lo que es esencial contar con indicadores que emitan señales de alerta tempranas para una identificación efectiva de riesgos.
•La evolución reciente de los indicadores de desequilibrios en los precios del sector inmobiliario señala que estos se mantienen en niveles moderados y cercanos a su valor de equilibrio, con datos hasta el tercer trimestre de 2023.
•Tras describir la evolución reciente de estos indicadores, se evalúa su capacidad predictiva mediante el análisis de la métrica AUROC (por las siglas en inglés de Area Under the Receiver Operating Characteristics Curve).
PENGARUH STRUKTUR MODAL, PROFITABILITAS, LIKUIDITAS DAN AKTIVITAS TERHADAP PERINGKAT OBLIGASI PERUSAHAAN SWASTA NON KEUANGAN YANG DIPERINGKAT PT. PEFINDO TAHUN 2017-2021
Authors: Manalu Asdius , Silalahi Donalson 
Published: July 2024

This study was conducted to identify and explain the factors that influence bond ratings in private non-financial companies that PT Pefindo in 2017-2021. Factors that affect bond ratings include capital structure, profitability, liquidity, and activity. Based on the criteria, 85 bonds from 11 companies were obtained as samples. The sample data is pooled cross sections data obtained from the Indonesia Bond Market Directory, and the publication of 11 companies' annual financial reports. So the multiple linear regression analysis method was chosen as the method of testing the sample of this study. The results showed that capital structure (DER) has a positive effect on bond ratings. Profitability (ROE), liquidity (CR), activity (TATO) do not affect the bond rating. The capital structure effect is not in accordance with the hypothesis because the sample companies use more equity. The r square (R2) value is 0.181 or 1.81% of the effect of financial ratios on bond ratings in 2017-2021 by PT Pefindo. The beta value of capital structure of 0.389 times means that capital has the most influence on bond ratings in this research.
Hubungan Tingkat Pengetahuan Kader Kesehatan Dengan Kinerja Kader Kesehatan Dalam Upaya Penanganan penyakit Tb Paru Di Puskesmas
Authors: Dedi Kurnia  , Wildan setiawan  , Nur Damayanti  
Published: July 2024

Tuberculosis paru merupakan suatu penyakit infeksi yang di sebabkan oleh mycrcobacterium tuberculosis yang menyerang paru-paru serta termasuk penyakit menular. Angka kejadian kasus tuberculosis terus meningkat secara drastis di seuruh dunia setiap tahunnya. Indonesia dilaporkan pada tahun 2015 sebagai Negara ke-2 kasus TBC terbanyak. Salah satu upaya dalam memutuskan angka penularan TBC yaitu dengan melakukan pencegahan penularan, khususnya yang di lakukan pasien TBC kepada anggota keluarganya, dengan keluarga berperan aktif dalam memberi dukungan kepada pasien dalam mencegah penularan kepada anggota keluarga. Penelitian ini menggunakan korelasi deskriptif dengan pendekatan cross sectional. Populasi pada penelitian ini adalah pasien TBC yang sedang menjalani pengobatan dan tercatat di UPT Yankes Kecamatan Pameungpeuk, dengan jumlah populasi 53 orang. Jumlah kuesioner keseluruhan dalam penelitian ini yaitu 61 item soal yang di bagi kedalam 2 varibel diantaranya, pada variabel dukungan keluarga memiliki jumlah soal sebanyak 33 item soal, pada variabel perilaku memiliki 28 item soal. Dengan tekhnik sampling total sampling dan uji rank spearman, di dapat hasil koefisien sebesar 0.538 dengan nilai p value = 0,001 dimana hasil tersebut menunjukan adanya hubungan yang positif, dengan kategori tingkat hubungan sedang. Semakin meningkatnya dukungan keluarga, maka semakin baik perilaku pasien dalam pencegahan penluran TBC paru.