bluuebunny/crossref_metadata_2025_split huggingface dataset:
A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression
Authors: Zhang Wei , Liu Songyang , Liu Kuai , Wang Yingchao , Ji Bai , Zhang Xuechun , Liu Yahui 
Published: March 2014

Objective A disintegrin and metalloprotease (ADAM)10 has been implicated in the progression of various solid tumours. Little is known, however, about its role in hepatocellular carcinoma (HCC). The aim of the present study was to evaluate the protein and transcript level expression of ADAM10 in HCC patients. Methods Samples of HCC and adjacent noncancerous liver tissue were taken during liver resection surgery. Immunostaining was used to measure ADAM10 protein expression levels and quantitative reverse– transcription polymerase chain reaction was used to measure ADAM10 mRNA expression levels. Levels of ADAM10 were compared, and a survival analysis undertaken. Results In total, 98 HCC patient samples were studied. There were significant associations between protein levels of ADAM10 and tumour grade, amount of tumour differentiation, tumour size and the presence of metastasis. Furthermore, ADAM10 protein expression was significantly associated with shortened patient survival. Conclusions ADAM10 is strongly expressed in a large proportion of HCC cases, which is in agreement with findings in other tumour entities. Expression of ADAM10 may serve as a useful molecular marker for HCC.
Deformation Mechanisms of Dry Textile Preforms under Mixed Compressive and Shear Loading
Authors: Ruggy Kevin L. , Cox Brian N. 
Published: March 2014

Elementary analyses of a standard compression test and a new test configuration for combined compression and shear illuminate the mechanisms of deformation of dry fiber bundles in fiber preforms under multi-axial loads. Such stress states are central to fiber bundle behavior in thick preforms that are being manipulated in pressurized tools. Sliding, buckling, compression, and shear deformation mechanisms are observed to operate at the single fiber bundle (tow) level. Shear includes deformation transverse to the axis of a tow (changes in cross-sectional shape) and axial shear (shear deflection of a tow segment acting as a short beam). Not all of these mechanisms have been addressed before in the extensive literature on textile deformation. The presence of multiple mechanisms complicates the quest for simple experiments that could be treated as standards for data acquisition. The need for new tests to be invented and standardized is highlighted.
Identifying the self-management behaviours performed by prostate cancer survivors: a systematic review of the evidence
Authors: Paterson Catherine , Jones Martyn , Rattray Janice , Lauder William 
Published: March 2014

Purpose Prostate cancer survivors are keen to engage as active partners in the management of their condition but have voiced a number of unmet support needs that make effective self-management problematic. Identifying self-management behaviours and evaluating how self-management changes over time may provide valuable insights into how men can be better supported to self-manage. Our systematic review aimed to identify the self-management behaviours for prostate cancer survivors and to evaluate whether these change over time. Methods Using the PRISMA statement we performed a systematic review of studies that identified the self-management behaviours of prostate cancer survivors. Databases searched included: DARE, CDSR, Medline, CINAHL, PsycINFO and ASSIA. Studies were classified by levels of evidence and quality assessment. Results 111 publications were retrieved from the search and 5 publications were included. Men performed a variety of self-management behaviours for psychological and physical problems. Only one study assessed changes in self-management behaviours over time and was limited to men treated by radiotherapy. Conclusion Despite the recent political drive for cancer survivors to self-manage, this review has demonstrated the evidence base is under-developed and a wide range of research is needed to address the unmet supportive care needs of prostate cancer survivors. Practically, this review has identified that Dodd’s Self-Care Log was found to have the strongest psychometric properties for additional research in this area.
Dabigatran etexilate for secondary stroke prevention: the first year experience from a multicenter short-term registry
Authors: Tsivgoulis Georgios , Krogias Christos , Sands Kara A. , Sharma Vijay K. , Katsanos Aristeidis H. , Vadikolias Konstantinos , Papageorgiou Sokratis G. , Heliopoulos Ioannis , Shiue Harn , Mitsoglou Athina , Liantinioti Chrissoula , Athanasiadis Dimitrios , Giannopoulos Sotirios , Piperidou Charitomeni , Voumvourakis Konstantinos , Alexandrov Andrei V. 
Published: March 2014

Background: There are growing concerns for the side effects of dabigatran etexilate (dabigatran), including higher incidence of dyspepsia and gastrointestinal bleeding. We conducted a multicenter early implementation study to prospectively evaluate the safety, efficacy and adherence to dabigatran for secondary stroke prevention. Methods: Consecutive atrial fibrillation (AF) patients with ischemic stroke (IS) or transient ischemic attack (TIA) received dabigatran for secondary stroke prevention during their hospital stay according to American Heart Association recommendations at five tertiary care stroke centers. The study population was prospectively followed and outcomes were documented. The primary and secondary safety outcomes were major hemorrhage and all other bleeding events respectively defined according to RE-LY trial methodology. Results: A total of 78 AF patients (mean age 71 ± 9years; 54% men; 81% IS, 19% TIA; median CHADS2 (Congestive heart failure, Hypertension, diabetes mellitus, age >75 years, prior stroke or TIA); range 2–5) score 4 were treated with dabigatran [(110mg bid (74%); 150mg bid (26%)]. During a mean follow-up period of 7 ± 5 months (range 1–18) we documented no cases of IS, TIA, intracranial hemorrhage, systemic embolism or myocardial infarction in AF patients treated with dabigatran. There were two (2.6%) major bleeding events (lower gastrointestinal bleeding) and two (2.6%) minor bleedings [hematuria ( n = 1) and rectal bleeding ( n = 1)]. Dabigatran was discontinued in 26% of the study population with high cost being the most common reason for discontinuation (50%). Discussion: Our pilot data indicate that dabigatran appears to be safe for secondary stroke prevention during the first year of implementation of this therapy. However, high cost may limit the long-term treatment of AF patients with dabigatran, leading to early discontinuation.
The cost of photoselective vaporization of the prostate compared to transurethral resection of the prostate: Experience in a large public Australian teaching centre
Authors: McCahy PJ , Cheng K , Paul E , Gleeson J 
Published: March 2014

Objective: The purpose of this study was to compare the cost of photoselective vaporization of the prostate (PVP) with transurethral resection of the prostate (TURP) in the treatment of men with bladder outflow obstruction (BOO). Patients and methods: Men underwent PVP or TURP for clinical BOO or urinary retention. We developed a cost framework to calculate the costs of theatre, recovery and ward time in our publically funded institution and calculated a cost for each procedure including the initial stay and any associated admissions over the first 60 days. These costs were statistically analyzed. Results: A total of 99 men underwent PVP and 97 had TURP. Groups were well matched for age and operative indication. The American Society of Anesthesia (ASA) grade was higher for the PVP group with more taking anticoagulants (36% versus 3.1%). PVP was 74% more expensive (median AUD$4243 vs AUD$2439, p<0.001) than TURP, even in a sub-set analysis excluding the anticoagulated patients. This was because of longer operating time and unavoidable disposable costs. Conclusions: Previous cost studies have all had significant flaws. Using our “bottom up” cost framework suggests that the unavoidable costs of purchasing a laser, single use laser fibers and other paraphernalia will almost always exceed the costs associated with in-patient stay. We caution against establishing a PVP service in a public hospital setting.
The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations
Authors: Schmidl Christian , Hansmann Leo , Lassmann Timo , Balwierz Piotr J. , Kawaji Hideya , Itoh Masayoshi , Kawai Jun , Nagao-Sato Sayaka , Suzuki Harukazu , Andreesen Reinhard , Hayashizaki Yoshihide , Forrest Alistair R. R. , Carninci Piero , Hoffmann Petra , Edinger Matthias , Rehli Michael 
Published: March 2014

Key Points
Transcription and enhancer profiling reveal cell type–specific regulome architectures and transcription factor networks in conventional and regulatory T cells.
Inequalities for the Casorati curvatures of slant submanifolds in quaternionic space forms
Authors: Slesar Vladimir , Şahin Bayram , Vîlcu Gabriel-Eduard 
Published: March 2014

Abstract
In this paper we prove two sharp inequalities that relate the normalized scalar curvature with the Casorati curvature for a slant submanifold in a quaternionic space form. Moreover, we show that in both cases, the equality at all points characterizes the invariantly quasi-umbilical submanifolds.
Buttock necrosis after hypogastric artery embolization for postpartum hemorrhage
Authors: Julve Robin , Meler Eva , Murillo Elena , Serra Bernat 
Published: March 2014

Abstract

Background: Uterine or hypogastric artery embolization is a useful alternative to hysterectomy in the treatment of postpartum hemorrhage.

Case: Puerpera requiring a bilateral hypogastric artery embolization for postpartum hemorrhage after cesarean section in a term twin pregnancy. Unexpected unilateral buttock necrosis appeared 5 days later. Treatment consisted of debridement, the use of vacuum-assisted closure therapy and skin grafting.

Conclusion: Buttock necrosis is a rare complication after hypogastric artery embolization in the treatment of postpartum hemorrhage.
Interfacial Phenomena in Fe/Stainless Steel–TiC Systems and the Effect of Mo
Authors: Kiviö Miia , Holappa Lauri , Yoshikawa Takeshi , Tanaka Toshihiro 
Published: March 2014

AbstractTitanium carbide is used as reinforcement particles in composites due to its hardness, wear resistance and stability. This work is a part of the study in which titanium carbides are formed in stainless steel castings in the mold to improve the wear resistance of a certain surface of the casting. Such local reinforcement is a very potential method but it is a quite demanding task requiring profound knowledge of interfacial phenomena in the system, wettability, stability, dissolution and precipitation of new phases in production of these materials. Good wetting between different constituents in the material is a key factor to attain maximal positive effects. Mo is used with TiC or Ti(C,N) reinforcement in composites to improve wettability. In this work the effect of Mo on the phenomena in Fe/stainless steel–TiC systems was examined by wetting experiments between the substrate and the alloy. Wetting was not significantly improved by adding Mo to the systems. Core-rim type carbides as well as more homogenous carbide particles were observed. Overall the carbide particles are very complex regarding to their chemistry, size and shape which aspects have to be taken into account in the development of these materials and manufacturing processes.
Single-source-precursor Synthesis and High-temperature Behavior of SiC Ceramics Containing Boron
Authors: Gui Miaomiao , Fang Yunhui , Yu Zhaoju 
Published: March 2014

AbstractIn this paper, a hyperbranched polyborocarbosilane (HPBCS) was prepared by a one-pot synthesis with Cl2Si(CH3)CH2Cl, Cl3SiCH2Cl and BCl3 as the starting materials. The obtained HPBCS was characterized by GPC, FT-IR and NMR, and was confirmed to have hyperbranched structures. The thermal property of the resulting HPBCS was investigated by TGA. The ceramic yield of the HPBCS is about 84% and that of the counterpart hyperbranched hydridopolycarbosilane is only 45%, indicating that the introduction of boron into the preceramic polymer significantly improved the ceramic yield. With the polymer-derived ceramic route, the final ceramics were annealed at 1800 °C in argon atmosphere for 2 h in order to characterize the microstructure and to evaluate the high-temperature behavior. The final ceramic microstructure was studied by XRD and SEM, indicating that the introduction of boron dramatically inhibits SiC crystallization. The boron-containing SiC ceramic shows excellent high-temperature behavior against decomposition and crystallization at 1800 °C.
Systems Genomics of Metabolic Phenotypes in Wild-TypeDrosophila melanogaster
Authors: Reed Laura K , Lee Kevin , Zhang Zhi , Rashid Lubna , Poe Amy , Hsieh Benjamin , Deighton Nigel , Glassbrook Norm , Bodmer Rolf , Gibson Greg 
Published: March 2014

AbstractSystems biology is an approach to dissection of complex traits that explicitly recognizes the impact of genetic, physiological, and environmental interactions in the generation of phenotypic variation. We describe comprehensive transcriptional and metabolic profiling in Drosophila melanogaster across four diets, finding little overlap in modular architecture. Genotype and genotype-by-diet interactions are a major component of transcriptional variation (24 and 5.3% of the total variation, respectively) while there were no main effects of diet (&lt;1%). Genotype was also a major contributor to metabolomic variation (16%), but in contrast to the transcriptome, diet had a large effect (9%) and the interaction effect was minor (2%) for the metabolome. Yet specific principal components of these molecular phenotypes measured in larvae are strongly correlated with particular metabolic syndrome-like phenotypes such as pupal weight, larval sugar content and triglyceride content, development time, and cardiac arrhythmia in adults. The second principal component of the metabolomic profile is especially informative across these traits with glycine identified as a key loading variable. To further relate this physiological variability to genotypic polymorphism, we performed evolve-and-resequence experiments, finding rapid and replicated changes in gene frequency across hundreds of loci that are specific to each diet. Adaptation to diet is thus highly polygenic. However, loci differentially transcribed across diet or previously identified by RNAi knockdown or expression QTL analysis were not the loci responding to dietary selection. Therefore, loci that respond to the selective pressures of diet cannot be readily predicted a priori from functional analyses.
Acid Demineralization Susceptibility of Dental Enamel Submitted to Different Bleaching Techniques and Fluoridation Regimens
Authors: Salomão DLF , Santos DM , Nogueira RD , Palma-Dibb RG , Geraldo-Martins VR 
Published: March 2014

SUMMARY
The aim of the current study was to assess the acid demineralization susceptibility of bleached dental enamel submitted to different fluoride regimens. One hundred bovine enamel blocks (6×6×3 mm) were randomly divided into 10 groups (n=10). Groups 1 and 2 received no bleaching. Groups 3 to 6 were submitted to an at-home bleaching technique using 6% hydrogen peroxide (HP; G3 and G4) or 10% carbamide peroxide (CP; G5 and G6). Groups 7 to 10 were submitted to an in-office bleaching technique using 35% HP (G7 and G8) or 35% CP (G9 and G10). During bleaching, a daily fluoridation regimen of 0.05% sodium fluoride (NaF) solution was performed on groups 3, 5, 7, and 9, while weekly fluoridation with a 2% NaF gel was performed on groups 4, 6, 8, and 10. The samples in groups 2 to 10 were pH cycled for 14 consecutive days. The samples from all groups were then assessed by cross-sectional Knoop microhardness at different depths from the outer enamel surface. The average Knoop hardness numbers (KHNs) were compared using one-way analysis of variance and Tukey tests (α=0.05). The comparison between groups 1 and 2 showed that the demineralization method was effective. The comparison among groups 2 to 6 showed the same susceptibility to acid demineralization, regardless of the fluoridation method used. However, the samples from groups 8 and 10 showed more susceptibility to acid demineralization when compared with group 2 (p&lt;0.05). Groups 7 and 9 provided similar results to group 2, but the results of those groups were different when compared with groups 8 and 10. The use of 6% HP and 10% CP associated with daily or weekly fluoridation regimens did not increase the susceptibility of enamel to acid demineralization. However, the use of 35% HP and 35% CP must be associated with a daily fluoridation regimen, otherwise the in-office bleaching makes the bleached enamel more susceptible to acid demineralization.
Estrogen and memory system bias in females across the lifespan
Authors: Hussain Dema , Shams Waqqas , Brake Wayne 
Published: March 2014

AbstractStudies in both rodents and humans have made much progress in shedding light on how fluctuations in ovarian hormones can affect memory in women across the lifespan. Specifically, advances in neuroscience have identified multiple memory systems that are each mediated by different brain areas. Two memory systems used to navigate an environment are ‘place’ and ‘response’ memory. They are defined as either using an allocentric strategy: using a spatial or cognitive map of the surroundings, or an egocentric strategy: using habitual-turns/movements, respectively. Studies in neuroendocrinology have shown that estrogen levels can bias a female to use one memory system over another to solve a task, such that high estrogen levels are associated with using place memory and low levels with using response memory. Furthermore, recent advances in identifying and localizing estrogen receptors in the rodent brain are uncovering which brain regions are affected by estrogen and providing insight into how hormonal fluctuations during the menstrual cycle, pregnancy, and menopause might affect which memory system is facilitated or impaired in women at different life stages. These studies can help point the way to improving cognitive health in women.
Brain-machine interfaces: an overview
Authors: Lebedev Mikhail 
Published: March 2014

AbstractBrain-machine interfaces (BMIs) hold promise to treat neurological disabilities by linking intact brain circuitry to assistive devices, such as limb prostheses, wheelchairs, artificial sensors, and computers. BMIs have experienced very rapid development in recent years, facilitated by advances in neural recordings, computer technologies and robots. BMIs are commonly classified into three types: sensory, motor and bidirectional, which subserve motor, sensory and sensorimotor functions, respectively. Additionally, cognitive BMIs have emerged in the domain of higher brain functions. BMIs are also classified as noninvasive or invasive according to the degree of their interference with the biological tissue. Although noninvasive BMIs are safe and easy to implement, their information bandwidth is limited. Invasive BMIs hold promise to improve the bandwidth by utilizing multichannel recordings from ensembles of brain neurons. BMIs have a broad range of clinical goals, as well as the goal to enhance normal brain functions.
Synthesis and phosphorescent properties of the copolymers of N-vinylcarbazole, methyl methacrylate and iridium complex
Authors: Wang Wen , Zhou Minglu , Liang Luying , Lin Meijuan , Ling Qidan 
Published: March 2014

Abstract
The copolymers containing carbazole unit and iridium complexes, such as (Ir(bpy)2Cl, Ir(mbpy)2Cl and Ir(Brbpy)2Cl, were synthesized via radical copolymerization of N-vinylcarbazole, methyl methacrylate and iridium complex. The synthesized copolymers were characterized by FT-IR, UV-Vis absorption spectroscopy and photoluminescence (PL) spectroscopy, respectively. According to the results, the copolymers (Ir(Brbpy)2Cl/PVK and Ir(mbpy)2Cl/PVK) exhibit yellow phosphorescence with an emission peak at around 553 nm under UV-visible light in the solid state. The results also reveal almost complete energy transfer from the host carbazole segments to the guest Ir complex in the copolymer film when the Ir content reaches 1.0 wt.%. The synthesized copolymers are good candidates as blue or yellow phosphorescent materials for PLED applications.
New data on the parasites of the Eurasian otter (Lutra lutra)
Authors: Rolbiecki Leszek , Izdebska Joanna 
Published: March 2014

Abstract
The Eurasian otter Lutra lutra (Linnaeus, 1758) is a typical representative of carnivorous mammals from the family of mustelids (Mustelidae) which are closely connected with aquatic ecosystems. Parasitofauna of the otter is poorly identified, e.g. only two specimens have been examined in Poland for the presence of parasites. Currently, three species of parasites were found in one otter: the nematode Oswaldocruzia filiformis (Goeze, 1782), the acanthocephalan Acanthocephalus ranae (Schrank, 1788) and the skin mite from the Demodecidae family. Demodex sp. is a new species to science, while O. filiformis and Demodex sp. are new parasites for the otter throughout the species range. Furthermore, A. ranae was found for the first time in the otter from the area of Poland. The recorded helminths are typical parasites of amphibians and reptiles, and their occurrence in the Eurasian otter may result from postcyclic transmission from primary hosts.
Analysis of selected surface water components in the town of Siedlce, Poland
Authors: Kluska Mariusz , Marciniuk-Kluska Anna 
Published: March 2014

Abstract
The paper presents results of a research study into levels of selected surface water components in Siedlce, Poland. Water was sampled in the Muchawka Reservoir and the Muchawka River in March, July and November 2012. Two techniques were applied in the study: isotachophoresis and atomic absorption spectrometry. The analysis results of water sampled in the Muchawka Reservoir indicate that they are borderline compliant with standards for the Class 1 surface waters. On the other hand, the Muchawka River samples were found to be out of any quality class.
Biting midges (Diptera: Ceratopogonidae) in tree hole habitats in Slovakia
Authors: Oboňa Jozef , Dominiak Patrycja 
Published: March 2014

Abstract
The water-filled tree hole fauna of biting midges (Diptera: Ceratopogonidae) in Slovakia is documented for the first time. Three Culicoides Latreille and two Dasyhelea Kieffer species were reared from these habitats. Epidemiological significance of C. obsoletus (Meigen, 1818) is briefly discussed.
The Pinnularia genus in south-eastern Poland with consideration of rare and new taxa to Poland
Authors: Noga Teresa , Peszek Łukasz , Stanek-Tarkowska Jadwiga , Pajączek Anita 
Published: March 2014

Abstract
In the studies conducted in 2007–2012 in south-eastern Poland, 56 diatom taxa were found from the Pinnularia genus. Pinnularia brebissonii (Kützing) Rabenhorst, P. obscura Krasske, P. viridiformis Krammer, P. lundii Hustedt, and P. viridis (Nitzsch) Ehrenberg occurred at most of the investigated sites. Eighteen taxa were considered as new to Polish flora. Some taxa are very rare in Poland and Europe and are found in only a few localities. Eight taxa are listed on the Polish Red List of Algae, including six taxa classified as endangered (E): P. nobilis (Ehrenberg) Ehrenberg, P. nodosa (Ehrenberg) W. Smith, P. subrupestris Hantzsch, P. schoenfelderii Krammer, P. subgibba Krammer and P. viridiformis Krammer.