bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Mineral Density in Survivors of Childhood Cancer: A Meta-Analysis
Authors: Velentza Lilly , Filis Panagiotis , Wilhelmsson Mari , Kogner Per , Herold Nikolas , Sävendahl Lars 
Published: July 2024

CONTEXT
There is an increasing population of childhood cancer survivors (CCS) at risk for treatment-related toxicities, including skeletal morbidities. Bone mineral density (BMD) is a proxy for bone health and reductions are associated with osteoporosis and fractures.

OBJECTIVE
To investigate bone health in CCS by conducting a systematic review and meta-analysis of BMD after completed treatments.

DATA SOURCES
We searched Medline, Embase, Cochrane, and Web of Science in May 2019 and updated in May 2023.

STUDY SELECTION
Studies reporting BMD Z-scores measured with dual-energy x-ray absorptiometry in CCS after treatment completion.

DATA EXTRACTION
We performed a pooled analysis of studies reporting BMD Z-scores and thereafter we analyzed studies comparing BMD in survivors and healthy controls. All analyses were performed based on the site of BMD measurement.

RESULTS
Of 4243 studies, 84 were included (N = 8106). The mean time off-treatment across the studies ranged from 2 months to 24 years. The overall pooled mean Z-score was −0.57 (95% confidence interval [CI] −0.59 to −0.55) in the whole-body, −0.84 (95% CI −0.86 to −0.83) in the lumbar spine, −0.79 (95% CI −0.81 to −0.77) in the femoral neck and −0.14 (95% CI −0.18 to −0.11) in the total hip. When comparing survivors with controls, BMD was significantly lower in survivors at all sites.

LIMITATIONS
English publications, study-level meta-analysis.

CONCLUSIONS
We showed a significant reduction of BMD Z-scores in CCS. Given the increased fracture risk already within −1 SD, these results emphasize the need for BMD surveillance and secondary prevention in CCS.
D.ADZEMOGLU AND D.ROBINSON CONCEPT OF SOCIAL DEVELOPMENT («NARROW CORRIDOR»): DETERMINATION OF HEURISTIC POTENTIAL FOR SOCIAL AND POLITICAL RESEARCH
Authors: DYOMKINA Yulia 
Published: July 2024

Emphasis placed on the search for new theoretical and methodological foundations for conducting modern social and political research. As the latter, it proposed to consider the leading propositions of the new version of the theory of social development by American researchers D.Acemoglu and J.Robinson, presented in their monograph «Narrow Corridor. States, Societies, and the Fate of Liberty» (2019).In the context of achieving the specified goal, the following tasks solved:– the content of the theory of social development by D.Acemoglu and D.Robinson («narrow corridor»);– the main ideas of the concept are compared with other theoretical constructions of social development proposed by leading Western researchers – R.Dahrendorf, S.Lipset, R.Englgart and . Habermas;– the strategy of applying the concept of «narrow corridor» in relation to the research of the leading elements of socio-political reality is determined.As a result, the following conclusions are drawn: firstly, this conceptual construction of D.Acemoglu and D.Robinson can be considered as a certain theoretical construction, claiming the level of a new version of the theory of social development; secondly, its structure is made up of leading provisions capable of interpreting both the static aspect of the existence of social and political reality (civil society – the state) and the dynamic one – the mechanism of its constant development (the struggle between the elites and the state, on the one hand, and the masses and civil society, on the other hand); thirdly, its heuristic potential for social and political research can be realized through the following research strategy: choosing a research subject; justification of the group of variables that can characterize it; determination of the set of factors that led to its occurrence; determination of the set of factors affecting its further development; consideration of the context of functioning and development of this subject of research – on the one hand, from the standpoint of civil society development, and, on the other – from the standpoint of further state building.
Development of Nearpod-Based Interactive Media to Optimize Religious Moderation
Authors: Adistya Ananda Feby , Yulia Nurul Mahruzah , Amreta Midya Yuli , Musthofa Muhammad Yunus 
Published: July 2024

The problem often faced by the world of education is students' attitudes towards learning. In fact, students easily get bored with learning that only uses textbooks in the form of worksheets in class. Students are more enthusiastic about smartphones than live games. Students also often show a lack of tolerance in learning. This research aims to describe the development process and results of developing interactive media on religious diversity in Indonesia based on Nearpod. Researchers used the Research and Development method with the ADDIE research model. This media has been validated by media experts with results of 88%, material experts with results of 90%, and learning experts with results of 82%. This media was tested on class IV students at Islamic Elementary School Fathul Ulum Sukosewu. The effectiveness of the media used is 0.61, which means that Nearpod-based interactive media is quite effective in optimizing religious moderation at Islamic Elementary School Fathul Ulum Sukosewu. Apart from that, with this media students can also better understand and understand other people's opinions. Permasalahan yang sering dihadapi dunia pendidikan adalah sikap siswa dalam pembelajaran. Bahkan, siswa gampang merasa bosan dengan pembelajaran yang hanya menggunakan buku ajar berupa LKS di kelas. Siswa lebih antusias dengan smartphone dari permainan langsung. Lemahnya sikap toleransi juga sering ditunjukkan siswa dalam pembelajaran. Penelitian ini bertujuan untuk mendeskripsikan proses pengembangan dan hasil pengembangan media interaktif materi keberagaman agama di Indonesia berbasis Nearpod. Peneliti menggunakan metode Research and Development (RND) dengan model penelitian ADDIE. Hasil penelitian menjelaskan bahwa Prosedur pengembangan media interaktif berbasis Nearpod ini menggunakan model pengembangan ADDIE yang terdiri dari lima langkah yaitu analysis, design, development, implementation, evaluation. Media ini telah di validasikan oleh ahli media dengan hasil 88%, ahli materi dengan hasil 90%, dan ahli pembelajaran dengan hasil 82%. Media ini di uji cobakan kepada siswa siswi kelas IV Madrasah Ibtidaiyah Fathul Ulum Sukosewu. Efektivitas media yang digunakan yaitu sebesar 0,61 yang berarti media interaktif berbasis Nearpod ini cukup efektif untuk mengoptimalkan moderasi beragama di Madrasah Ibtidaiyah Fathul Ulum Sukosewu. Selain itu, dengan media ini siswa juga dapat lebih mengerti dan memahami pendapat orang lain.
Lysosomal-Associated Protein Transmembrane 5, Tubular Senescence, and Progression of CKD
Authors: Liu Xiaohan , Zhan Ping , Zhang Yang , Jin Huiying , Wang Youzhao , Yang Yujie , Wang Ziying , Wang Xiaojie , Xu Qianqian , Zhen Junhui , Sun Rong , Sun Jinpeng , Liu Min , Yi Fan 
Published: July 2024

Key Points

Lysosomal-associated protein transmembrane 5 (LAPTM5) is increased in tubular epithelial cells in CKD.Conditional knockout of Laptm5 in tubules attenuates kidney fibrosis in mice with CKD.LAPTM5 contributes to tubular senescence by inhibiting WWP2-mediated ubiquitination of notch1 intracellular domain.

Background
Tubular senescence is a major determinant of CKD, and identification of potential therapeutic targets involved in senescent tubular epithelial cells has clinical importance. Lysosomal-associated protein transmembrane 5 (LAPTM5) is a key molecule related to T- and B-cell receptor expression and inflammation. However, the expression pattern of LAPTM5 in the kidney and the contribution of LAPTM5 to the development of CKD are unknown.

Methods

Laptm5

−/−
mice and tubule specific–Laptm5 knockout mice were used to examine the role of LAPTM5 in tubular senescence by establishing different experimental mouse CKD models.

Results
LAPTM5 expression was significantly induced in the kidney, especially in proximal tubules and distal convoluted tubules, from mice with aristolochic acid nephropathy, bilateral ischemia/reperfusion injury–induced CKD, or unilateral ureter obstruction. Tubule-specific deletion of Laptm5 inhibited senescence of tubular epithelial cells and alleviated tubulointerstitial fibrosis in aged mice. Moreover, Laptm5 deficiency ameliorated kidney injury and tubular senescence in mice with CKD. Mechanistically, LAPTM5 inhibited ubiquitination of notch1 intracellular domain by mediating WWP2 lysosomal degradation and then leading to cellular senescence in tubular epithelial cells. We also observed a higher expression of LAPTM5 in tubules from patients with CKD, and the level of LAPTM5 was correlated with kidney fibrosis and tubular senescence in people with CKD.

Conclusions
LAPTM5 contributed to tubular senescence by regulating the WWP2/notch1 intracellular domain signaling pathway and exacerbated kidney injury during the progression of CKD.
Meningkatkan Kemampuan Bahasa Anak Usia Dini melalui Media Papan Telur Ayam Alfabet di TK Al-Afiya Medan
Authors: Amalia Kartika Tri , Ramita Ramita , Arlina Arlina , Af-Idah Shofiyatul 
Published: July 2024

This research aims to improve the language skills of young children through the use of alphabet chicken egg board media at Al-Afiya kindergarten Medan. The research method used is qualitative with a descriptive approach. Data was collected through questionnaires, observation, interviews and documentation. The results of the research show that the use of alphabet chicken egg board media in Al-Afiya kindergarten is effective in improving the language skills of young children. This research centributes to the development of innovative and effective learning methods in improving the language skills of early childhood. These findings can be a reference for educational institutions and educators in developing effective learning strategies in developing language skills in early childhood.|Penelitian ini bertujuan untuk meningkatkan kemampuan bahasa anak usia dini melalui penggunaan media papan telur ayam alfabet di TK Al-Afiya Medan. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan deskriptif. Data dikumpulkan melalui kuesioner, observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa penggunaan media papan telur ayam alfabet di TK Al-Afiya efektif dalam meningkatkan kemampuan bahasa anak usia dini. Penelitian ini memberikan kontribusi terhadap pengembangan metode pembelajaran yang inovatif dan efektif dalam meningkatkan kemampuan bahasa anak usia dini. Temuan ini dapat menjadi acuan bagi lembaga pendidikan dan para pendidik dalam mengembangkan strategi pembelajaran yang efektif dalam pengembangan kemampuan bahasa anak usia dini.
Implications of Activity Rate Characterization and Fault-Based Partitioning on Probabilistic Seismic Hazard Assessment: A Case Study of Extensional Tectonic Regime in Western Anatolia, Türkiye
Authors: Shah Syed Tanvir , Özacar Atilla Arda , Gülerce Zeynep 
Published: July 2024

ABSTRACT
Complex fault geometries with multiple sets of inclined active faults pose a challenge to the accurate representation of fault-based seismic sources in probabilistic seismic hazard assessment (PSHA). In the absence of slip rates associated with fault segments and the presence of sparse seismic and geodetic data, the estimation of segment-specific activity rate includes significant uncertainty. This study proposes a comprehensive procedure for defining the segment-specific activity rates and associated uncertainties in fault-based PSHA for extensional tectonic regimes and applies the procedure in the northern margin of Western Anatolian Extensional Province. The seismic sources are modeled as rupture systems with individual fault segments using the connections between available active fault traces, first-order geological complexities, earthquake catalog, and focal mechanism solutions. Alternatives to estimate and partition segment-specific activity rates based on annual slip rate, seismicity rate, and moment rate are explored. Each alternative is implemented in PSHA, and the results are compared in terms of peak ground acceleration (PGA) maps for a 475-year return period. A comparison of the 475 yr PGA maps showed that the activity rates based on annual slip rates translate into higher hazard estimates and a more uniform distribution of PGA; whereas, the activity rates based on seismicity and moment rate result in a PGA distribution that is more sensitive to the occurrence and location of previous large-magnitude events. The approach utilized to partition activity rates among parallel segments has a noticeable effect in the areas where highly asymmetric fault activity is inferred from morphology. Hence, alternative approaches for estimation and partition of activity rates are combined to model the epistemic uncertainty in segment-specific activity rates, and a repeatable procedure is developed to build fault-based seismic source models in the presence of complex fault geometries.
Oxylipins in Aqueous Humor of Primary Open Angle Glaucoma Patients
Authors: Xu Jianming , Zhou Kewen , Fu Changzhen , Chen Chong-Bo , Sun Yaru , Wen Xin , Yang Luxi , Tsz Kin Ng , Liu Qingping , Zhang Mingzhi 
Published: July 2024

PURPOSE: To investigate the oxylipin profiles in aqueous humor of primary open angle glaucoma (POAG) patients.
METHODS: Aqueous humor samples were collected from 17 POAG patients and 15 cataract subjects and subjected to the liquid chromatography-mass spectrometry (LC-MS) analysis to detect the oxylipins. The prediction potential of the differential abundant oxylipins was assessed by the receiver operating characteristic (ROC) curves. Pathway and correlation analyses on the oxylipins and clinical and biochemical parameters were also conducted.
RESULTS: The LC-MS analysis detected a total of 76 oxylipins, of which 29 oxylipins reached the detection limit. The multivariate analysis identified 5 differential abundant oxylipins, 15-keto-prostaglandin F2 alpha (15-kPGF2α), Leukotriene B4 (LTB4), 12,13-Epoxyoctadecenoic acid (12,13-Epome), 15-Hydroxyeicosatetraenoic acid (15-HETE) and 11-Hydroxyeicosatetraenoic acid (11-HETE). The 5 oxylipins are enriched in the arachidonic acid metabolism and linoleic acid metabolism pathways. Pearson correlation analysis showed that 11-HETE was positively correlated with intraocular pressure and central corneal thickness and negatively with cup/disk ratio in the POAG patients. In addition, 15-kPGF2α was positively correlated with visual field defect, and LTB4 was negatively correlated with macular thickness.
CONCLUSIONS: This study revealed the oxylipin profile in the aqueous humor of POAG patients. Oxylipins involved in arachidonic acid metabolism pathway could play a role in POAG and anti-inflammatory therapies could be potential treatment strategies for POAG.
Mechanism of magnetic phase transition in correlated magnetic metal: insight into metallic ferromagnet Fe3-δGeTe2
Authors: Tian Fuyang , Xu Yuanji , Wang Yuechao , Jin Xintao , Liu Haifeng , Liu Yu , Song Haifeng 
Published: July 2024

Abstract

Developing a comprehensive magnetic theory of correlated itinerant magnets is a challenging task due to the difficulty in reconciling both local moments and itinerant electrons. In this work, we investigate the microscopic process of magnetic phase transition in ferromagnet metal Fe3-δGeTe2. A new paradigm is proposed to describe the magnetic phase transition in correlated metallic ferromagnets, where Hund's coupling dominates the spectral weight transfer between different spin channels, rather than spin-splitting as described by the Stoner model. We recognize that our theory should be universal for itinerant magnets. Additionally, we reveal an efficient way to achieve novel quantum states from various competing orders in multi-site crystal structures. Our research shows that Fe1 are proximate to Mott physics, while Fe2 exhibit Hund physics due to their distinct atomic environments. These competing orders work together to produce heavy fermion behavior within ferromagnetic long-range order through well-defined quasiparticle bands, which are promoted by Hund's coupling and further hybridized with relative itinerant bands. The complex interactions of competing orders drive correlated magnetic metal to a new frontier for discovering outstanding quantum states and exotic phenomena in condensed matter physics.
The AP2/ERF transcription factor MhERF113-like positively regulates drought tolerance in transgenic tomato and apple
Authors: Tian Jianwen , Yuan Penghao , Gao Xiang , Wang Hongtao , Wang Miaomiao , Jiao Jian , Zhang Kunxi , Hao Pengbo , Song Chunhui , Zheng Xianbo , Bai Tuanhui 
Published: July 2024

Abstract

Drought is a major abiotic stress in agriculture that severely affects crop growth, yield, and quality. The APETALA2/ethylene responsive factor (AP2/ERF) plays a crucial role in maintaining plant growth, development, as well as stress tolerance. Herein, we cloned and characterized theMhERF113-like gene fromMalus hupehensis.MhERF113-like is significantly induced by drought and highly expressed in leaves. Overexpression ofMhERF113-like positively regulated the drought tolerance of apple callus, as judged by less electrolyte leakage, lower malonaldehyde (MDA) and hydrogen peroxide (H2O2) contents in OE than those of the WT apple callus under drought stress. In addition, ectopic expression ofMhERF113-like gene in tomatoes improved the drought tolerance, accompanied by enhanced expression of antioxidant genes (SlAPXandSlSOD) and stress responsive genes (SlDREB2AandSlRD29), and reduced H2O2and O2-contents in transgenic tomato. Taken together, our study demonstrated thatMhERF113-like may play an important role in the regulation of plant drought tolerance, which may provide a key factor for future biotechnology applications to improve drought stress tolerance in plants.
Fire and ant interactions mediated by honeydew and extrafloral nectar in an Australian tropical savanna
Authors: Oliveira Fernanda M.P. , Silva Carlos H. F. , Moir Melinda L. , Leal Inara R. , Andersen Alan N. 
Published: July 2024

Abstract

Fire is a major disturbance affecting ecosystems globally, but its impact on mutualisms has received minimal attention. Here, we use a long-term field experiment to investigate the impact of different fire regimes on globally important ant-honeydew and ant-extrafloral nectar (EFN) mutualistic interactions in an Australian tropical savanna. These interactions provide ants with a key energy source, while their plant and hemipteran hosts receive protection services. We examined ant interactions on species of Eucalyptus (lacking EFNs) and Acacia (with EFNs) in three replicate plots each of burning every two and three years early in the dry season, burning late in the dry season every two years, and unburnt for > 25 years. The proportions of plants with ant-honeydew interactions in Acacia (44.6%) and Eucalyptus (36.3%) were double those of Acacia plants with ant-EFN interactions (18.9%). The most common ants, representing 85% of all interactions, were behaviourally dominant species of Oecophylla, Iridomyrmex and Papyrius. Fire promoted the incidence of ant interactions, especially those involving EFNs on Acacia, which occurred on only 3% of plants in unburnt plots compared with 24% in frequently burnt plots. Fire also promoted the relative incidence of behaviourally dominant ants, which are considered the highest-quality mutualists. Contrary to expectations, frequent fire did not result in a switching of behaviourally dominant ant partners from forest-adapted Oecophylla to arid-adapted Iridomyrmex. Our findings that frequent fire increases ant interactions mediated by honeydew and extrafloral nectar, and promotes the quality of ant mutualists, have important implications for protective services provided by ants in highly fire-prone ecosystems.
Statin Targeted Treatment Against Intimal Hyperplasia Using Unique Chitosan-PLGA Nanoparticles
Authors: Peters Ashley A. , Poland Gloria Grace , Cabe Maleen , Kaur Chanpreet , Langert Kelly , Maier Kristopher , Gahtan Vivian 
Published: July 2024

Abstract

Introduction:
Statins have pleiotropic effects, including reducing intimal hyperplasia (IH). Using unique nanoparticle (NPs), we hypothesized chitosan-functionalized polymeric NPs loaded with simvastatin (SL-cNPs) would: 1) readily associate with endothelial cells (ECs) and vascular smooth muscle cells (VSMCs); 2) affect EC and VSMC function; and 3) reduce IH compared to systemic simvastatin.
Methods
Human aortic ECs and VSMCs were cultured with SL-cNPs tagged with fluorescent tracer. Association of SL-cNPs was assessed by immunostaining and flow cytometry. The effect of SL-cNPs, empty cNPs (E-cNPs) and free simvastatin on cells was determined using RT-qPCR for RhoA and RhoB. Carotid artery balloon injured rats were treated intraoperatively with intraluminal saline, E-cNPs, low or high dose SL-cNPs; or with pre- and post-operative oral simvastatin plus intraoperative intraluminal saline or low dose SL-cNPs. Rats were euthanized (day 14) and IH was quantified.
Results
SL-cNPs readily associated with ECs and VSMCs. Low and high dose SL-cNPs induced significant increases in EC and VSMC RhoA gene expression. High dose SL-cNPs induced a significant increase in EC RhoB expression, while free simvastatin, low and high dose SL-cNPs significantly increased RhoB expression in VSMCs. In vivo, oral simvastatin plus intraluminal SL-cNPs significantly reduced IH compared to controls.
Conclusion
cNPs can be used as a novel vehicle to locally deliver statins to vascular cells. Although only the combination of oral simvastatin and SL-cNPs effectively reduced IH, different routes of delivery and/or concentration of SL-cNPs may allow for a more robust effect on IH prevention.
Socioeconomic Attributes of Households and Their Implications for Housing Development in Peri-urban Areas of Akure, Nigeria
Authors: Lawal Olubunmi Lukman , Omole Felix Kayode , Basorun Joseph Omoniyi , Oladehinde Gbenga 
Published: July 2024

Abstract

The rapidly growing population of Akure and the accompanying economic activities have led to the city's expansion to the adjoining peri-urban areas. Many households who could not afford decent accommodation in the town have been moving to the peri-urban regions for rental or personal housing. Therefore, this study explored the connection between the socioeconomic characteristics of households and housing development in Oba-Ile, Oda, and Ibule-Soro peri-urban areas of Akure. In this study, households represent the unit of analysis, and one household head per building was selected for questionnaire administration. Using the average household size of five people per family (5ppf) and five households per building (5hpb) in Ondo State, the number of households in the three locations was forty-seven thousand one hundred and ten (47110), out of which eight hundred (800) representing 1.7% of the households were randomly selected for questionnaire administration. The data obtained from the field survey was subjected to statistical analysis and the results among others revealed that most of the housing units were headed by males, who were between 45 and 54 years old, and within Nigeria's economically active population; 67.2%, 65.1%, and 46.4% of the respondents in Ibule-Soro, Oda, and Oba-Ile, respectively, lived below the poverty line; and most of the housing development were traced to the last ten years. Based on the findings, credible proposals were made to improve socioeconomic characteristics, which will drive adequate housing development.