bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Chiral Magnesium(II) Binaphtholates as Cooperative Broensted/Lewis Acid—Base Catalysts for the Highly Enantioselective Addition of Phosphorus Nucleophiles to α,β‐Unsaturated Esters and Ketones.
Authors: Hatano Manabu , Horibe Takahiro , Ishihara Kazuaki 
Published: August 2013

AbstractBy using this simple and practical title catalyst a wide range of different substituted organo‐phosphorus compounds can be obtained, which are in some cases difficult to synthesize, e.
ChemInform Abstract: Synthesis of Salidroside Analogues and Their Ability of DPPH Radical Scavenging Activity.
Authors: Zheng Cheng , Guo Yibing , Meng Ying , Dou SuFeng , Shao Jian , Yang YuMin 
Published: August 2013

Abstractβ‐D‐Galacto‐ and β‐D‐glucopyranoside derivatives [(I), (II) and (III)] are evaluated for their DPPH radical scavenging activity.
ChemInform Abstract: Recent Report on Thiono[2,3‐d]pyrimidines. Their Preparation Including Microwave and Their Utilities in Fused Heterocycles Synthesis
Authors: Aly Ashraf A. , Ishak Esam A. , Ramadan Mohamed , Germoush Mousa O. , El‐Emary Talaat I. , Al‐Muaikel Nayef S. 
Published: August 2013

AbstractReview: 87 refs.
Green wireless local area network received signal strength dimensionality reduction and indoor localization based on fingerprint algorithm
Authors: Ma Lin , Zhou Caifa , Qin Danyang , Xu Yubin 
Published: August 2013

SUMMARYGreen wireless local area network (WLAN) is an emerging technology to achieve both the purposes of power conservation and high‐speed accessing to the Internet because of the working on‐demand strategy adoption and high density access points (APs) deployment. Although it is good news to data traffic service, Green WLAN brings severe challenges to the indoor localization service based on fingerprint algorithm. Redundant APs will greatly enlarge the radio map and introduce a much heavier computation burden to the terminal for localization in the online phase. In addition, APs in Green WLAN are powered on and off to make balances between data traffic service demand and energy saving goals so that the received signal strength (RSS) sampled online and recorded in the radio map offline are rarely matched in the same detected AP number, which leads to asymmetric matching problem occurring in the fingerprint algorithm. In this paper, we propose to make a nonlinear dimensionality reduction on the RSS by local discriminant embedding algorithm to realize both the computation burden decreasing and asymmetric matching problem resolving for the fingerprint algorithm in Green WLAN. The simulation results show that our proposed methods could effectively reduce the computation burden in the online phase and make the fingerprint algorithm operate more robustly when the RSS is reduced to the intrinsic dimensionality in Green WLAN. Copyright © 2013 John Wiley & Sons, Ltd.
CoPoMo: a context‐aware power consumption model for LTE user equipment
Authors: Dusza Bjoern , Ide Christoph , Cheng Liang , Wietfeld Christian 
Published: August 2013

ABSTRACTIncreasing the battery lifetime of power‐hungry mobile devices has become a major research target for mobile operators. Based on extensive measurement campaigns with the most recent Long Term Evolution (LTE) devices, we introduce a new Markovian power consumption model, which takes into account the chosen system parameters (such as the number of physical resource blocks) as well as the context of a user in terms of radio channel conditions and service characteristics (non‐real‐time vs. real time). One key advancement of this generic model is its stochastic nature, which allows for determining the average power consumption of a device based on usage profiles including location information and service statistics. We have conducted comprehensive system simulations using realistic channel characteristics derived from ray‐tracing analyses and validated the new model. Finally, we show that the proposed context‐aware power consumption model enables quantitative analyses of the trade‐off between network resource allocation and enhanced battery lifetime. © 2013 The Authors. Transactions on Emerging Telecommunications Technologies published by John Wiley & Sons, Ltd.
Expression of sex hormone receptors in juvenile angiofibromas and antiproliferative effects of receptor modulators
Authors: Schick Bernhard , Dlugaiczyk Julia , Wendler Olaf 
Published: August 2013

AbstractBackgroundPredilection of juvenile angiofibromas in adolescent boys has prompted the hypothesis of hormone‐dependent tumor growth. However, knowledge on expression and function of sex hormone receptors in juvenile angiofibromas is still sparse and inconsistent.MethodsTranscript and protein expression of sex hormone receptors in juvenile angiofibromas was studied by quantitative reverse transcriptase–polymerase chain reaction (qRT‐PCR) and immunohistology/fluorescence. A bromodeoxyuridine assay was used to assess the antiproliferative effects of flutamide (androgen receptor antagonist) and tamoxifen (estrogen receptor modulator).ResultsSignificantly increased transcript levels were observed for androgen receptor, estrogen receptor α, follicle‐stimulating hormone receptor, and luteinizing hormone receptor in juvenile angiofibromas versus the stroma of nasal mucosa. Estrogen receptor β and progesterone receptor mRNA levels were low and similar for both tissues. Estrogen receptor α protein was detected in juvenile angiofibroma tumors and mesenchymal cell lines. Flutamide and tamoxifen inhibited proliferation of cultured juvenile angiofibroma mesenchymal cells.ConclusionThese findings contribute to the understanding of juvenile angiofibroma pathophysiology and offer novel therapeutic options. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1596–1603, 2014
Concurrent chemoradiotherapy with nedaplatin plus paclitaxel or fluorouracil for locoregionally advanced nasopharyngeal carcinoma: Survival and toxicity
Authors: Xu Jianhua , He Xia , Cheng Kong , Guo Wenjie , Bian Xiuhua , Jiang Xuesong , Zhang Lanfang , Huang Shengfu 
Published: August 2013

AbstractBackgroundThe purpose of this study was to review the survival and toxicity in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated with intensity‐modulated radiation therapy (IMRT) and concurrent nedaplatin plus paclitaxel or fluorouracil (NP or NF).MethodsA total of 155 patients with locoregionally advanced NPC seen at our institution between January 2008 and December 2010 were retrospectively reviewed. Seventy‐nine cases (51%) were treated with IMRT and concurrent NP chemotherapy, and 76 cases (49%) were treated with IMRT and concurrent NF regimen. Survival and toxicity were reported.ResultsThe 3‐year locoregional relapse‐free survival, distant metastasis–free survival, progression‐free survival (PFS), and overall survival (OS) rates were 90.3% and 87.8%, 79.7% and 81.1%, 77.3% and 71.1%, and 81.6% and 83.7% for the NF and NP group, respectively. The results were comparable to that of the cisplatin‐based regimens. Acute and late toxicities were acceptable.ConclusionIMRT with concurrent nedaplatin‐based chemotherapy achieved comparable survival with acceptable toxicity to those of the cisplatin‐based regimens in the treatment of locoregionally advanced NPC. © 2014 Wiley Periodicals, Inc. Head Neck, 36: 1474–1480, 2014
Proteomic profiling in incubation medium of mouse, rat and human precision‐cut liver slices for biomarker detection regarding acute drug‐induced liver injury
Authors: van Swelm Rachel P. L. , Hadi Mackenzie , Laarakkers Coby M. M. , Masereeuw Rosalinde , Groothuis Geny M. M. , Russel Frans G. M. 
Published: August 2013

ABSTRACTDrug‐induced liver injury is one of the leading causes of drug withdrawal from the market. In this study, we investigated the applicability of protein profiling of the incubation medium of human, mouse and rat precision‐cut liver slices (PCLS) exposed to liver injury‐inducing drugs for biomarker identification, using matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry. PCLS were incubated with acetaminophen (APAP), 3‐acetamidophenol, diclofenac and lipopolysaccharide for 24–48 h. PCLS medium from all species treated with APAP demonstrated similar changes in protein profiles, as previously found in mouse urine after APAP‐induced liver injury, including the same key proteins: superoxide dismutase 1, carbonic anhydrase 3 and calmodulin. Further analysis showed that the concentration of hepcidin, a hepatic iron‐regulating hormone peptide, was reduced in PCLS medium after APAP treatment, resembling the decreased mouse plasma concentrations of hepcidin observed after APAP treatment. Interestingly, comparable results were obtained after 3‐acetamidophenol incubation in rat and human, but not mouse PCLS. Incubation with diclofenac, but not with lipopolysaccharide, resulted in the same toxicity parameters as observed for APAP, albeit to a lesser extent. In conclusion, proteomics can be applied to identify potential translational biomarkers using the PCLS system. Copyright © 2013 John Wiley & Sons, Ltd.
Direct conversion of CO2 with diols, aminoalcohols and diamines to cyclic carbonates, cyclic carbamates and cyclic ureas using heterogeneous catalysts
Authors: Tamura Masazumi , Honda Masayoshi , Nakagawa Yoshinao , Tomishige Keiichi 
Published: August 2013

AbstractCO2 has a large effect on global warming by greenhouse gases, and development of an effective technique for the reduction of CO2 is a crucial and urgent issue. From the chemical viewpoint, CO2 is regarded as a stable, safe and abundant C1 resource, and the transformation of CO2 to valuable chemicals is promising not only for reduction of CO2 but also for production of useful chemicals. This mini‐review focuses on the direct conversion of CO2 with diols, aminoalcohols and diamines to cyclic compounds such as cyclic carbonates, cyclic carbamates and cyclic ureas, and in particular discusses the mechanisms for these reactions over heterogeneous catalysts. © 2013 Society of Chemical Industry
Continuous catchment‐scale monitoring of geomorphic processes with a 2‐D seismological array
Authors: Burtin Arnaud , Hovius Niels , Milodowski David T. , Chen Yue‐Gau , Wu Yih‐Min , Lin Ching‐Weei , Chen Hongey , Emberson Robert , Leu Peih‐Lin 
Published: August 2013

AbstractDistributed activity of geomorphic processes with different spatiotemporal scales is hard to monitor in detail with conventional methods but might be detected with seismometers. From July to September 2010, we deployed 14 seismometers to evaluate the ability of a two‐dimensional array with small interstation distances (11 km) to continuously monitor geomorphic processes in a mountain catchment (370 km2) in Taiwan. Spectral analysis of seismic records highlights different sources with high‐frequency content (>1 Hz), consistent with hillslope and river processes. Using a common detection algorithm and a location technique based on the timing of seismic amplitude, we have located 314 near‐surface events, most of which (69%) occurred during daily convective storms. Event activity was positively correlated with the precipitation intensity, but this relation was not uniform in the catchment. High‐resolution satellite images and air photos did not show geomorphic change during the study, which did not have any episodes of extreme precipitation. A majority of events (61%) were collocated with preexisting geomorphic features (landslide scars, gullies) within the uncertainty on location (9% of interstation distance). The combination of event location and timing suggests a geomorphic source of recorded signals and most events had the seismic characteristics of rockfall, debris avalanches, or slides. Reactivation of prior erosion sites by such processes is difficult to detect with imagery, but can possibly be resolved by seismic monitoring. When proven, this approach will allow a spatially comprehensive survey of geomorphic activity at the catchment scale, with temporal detail sufficient to evaluate the exact (meteorological) conditions under which process events occur.
Protective effects of coffee against induction of DNA damage and pre‐neoplastic foci by aflatoxin B1
Authors: Ferk Franziska , Huber Wolfgang W. , Grasl‐Kraupp Bettina , Speer Karl , Buchmann Sandra , Bohacek Rene , Mišík Miroslav , Edelbauer Leopold , Knasmüller Siegfried 
Published: August 2013

ScopeAim of the study was to investigate the protective properties of coffee towards aflatoxin B1 (AFB1) induced formation of pre‐neoplastic hepatic foci and the identification of the constituents and molecular mechanisms that account for these effects.Materials and methodsRats consumed three different brews and were subsequently treated with AFB1 (0.75 mg/kg b.w. intraperitoneally). Ten weeks later, the numbers and areas of hepatic foci were determined. Furthermore, the impact of the brews on AFB1‐induced DNA damage was quantified in single cell gel electrophoresis assays and the activities of drug metabolising enzymes and glutathione‐related parameters were monitored. Additionally, single cell gel electrophoresis assay experiments were conducted with pure caffeine.ConclusionAll brews reduced the frequencies of the hepatic foci. The most pronounced protection (reduction 82%) was seen with the caffeine containing metal and paper filtered brews. DNA migration was reduced between 65 and 75% with the caffeine containing brews. In additional experiments, clear protective effects were found with caffeine at dose levels that corresponded to those contained in the coffee. This observation indicates that the alkaloid accounts partly for the protective effects of coffee. Furthermore, our findings indicate that induction of UDP‐glucuronosyltransferase contributes to the chemopreventive effects of coffee since all brews increased the activity of this detoxifying enzyme.
Selection bias in pharmacy‐based patient surveys
Authors: Frisk P , Kälvemark‐Sporrong S , Wettermark B 
Published: August 2013

ABSTRACTPurposeTo evaluate if there is a selection bias in drug utilization surveys on prescription drugs regularly conducted in Swedish pharmacies, to describe the direction of this potential bias and discuss the implications for the results.MethodsAge and gender distributions within patient survey samples from drug utilization surveys conducted during 2006–2010 are compared to the age and gender distribution of all Swedish patients, receiving the same drug or drugs, as given by the Swedish Prescribed Drug Register. The differences between the proportions of patients within the age and gender segments of each pair of survey/register data were calculated.ResultsIn 25 (81%) out of 31 included surveys, patients aged 75 years or older are significantly underrepresented, as they are less likely to visit the pharmacy to collect their prescription drugs themselves and thus disqualify for the interviews. Data on women show similar results as overall survey data, whereas the underrepresentation of the oldest age group among men appears in a lower proportion of the surveys, 67%. The general consequence is a selection towards a healthier survey sample, but the consequences in the individual surveys vary, depending on what drug is being studied.ConclusionPharmacy‐based patient surveys provide a convenient data collection method for patient self‐reported data, but patients aged 75 years or older are consistently underrepresented. In surveys where this may influence the main research question, data should also be collected with other methods reaching the oldest patients. Copyright © 2013 John Wiley & Sons, Ltd.
Maturation of the developing human fetal prostate in a rodent xenograft model
Authors: Saffarini Camelia M. , McDonnell Elizabeth V. , Amin Ali , Spade Daniel J. , Huse Susan M. , Kostadinov Stefan , Hall Susan J. , Boekelheide Kim 
Published: August 2013

AbstractBACKGROUNDProstate cancer is the most commonly diagnosed nonskin cancer in men. The etiology of prostate cancer is unknown, although both animal and epidemiologic data suggest that early life exposures to various toxicants, may impact DNA methylation status during development, playing an important role.METHODSWe have developed a xenograft model to characterize the growth and differentiation of human fetal prostate implants (gestational age 12–24 weeks) that can provide new data on the potential role of early life stressors on prostate cancer. The expression of key immunohistochemical markers responsible for prostate maturation was evaluated, including p63, cytokeratin 18, α‐smooth muscle actin, vimentin, caldesmon, Ki‐67, prostate‐specific antigen, estrogen receptor‐α, and androgen receptor. Xenografts were separated into epithelial and stromal compartments using laser capture microdissection (LCM), and the DNA methylation status was assessed in >480,000 CpG sites throughout the genome.RESULTSXenografts demonstrated growth and maturation throughout the 200 days of post‐implantation evaluation. DNA methylation profiles of laser capture microdissected tissue demonstrated tissue‐specific markers clustered by their location in either the epithelium or stroma of human prostate tissue. Differential methylated promoter region CpG‐associated gene analysis revealed significantly more stromal than epithelial DNA methylation in the 30‐ and 90‐day xenografts. Functional classification analysis identified CpG‐related gene clusters in methylated epithelial and stromal human xenografts.CONCLUSIONThis study of human fetal prostate tissue establishes a xenograft model that demonstrates dynamic growth and maturation, allowing for future mechanistic studies of the developmental origins of later life proliferative prostate disease. Prostate 73:1761–1775, 2013. © 2013 Wiley Periodicals, Inc.
Multiple access in DVB‐RCS2 user uplinks
Authors: Munari Andrea , Acar Guray , Kissling Christian , Berioli Matteo , Lexow Hans Peter 
Published: August 2013

SUMMARYDigital Video Broadcasting, Return Channel via Satellite 2 (DVB‐RCS2) is the second generation of DVB‐RCS communication specification for the return link in broadband interactive geostationary satellite networks. The focus of this paper is the user uplink access mechanism in DVB‐RCS2. The first part of the paper provides a brief description of DVB‐RCS2 user uplink access, with emphasis on improvements with respect to the first generation of the standard. One of these improvements in DVB‐RCS2 is the support for random access (RA) for user traffic. The second part of the paper further delves into the RA load control problem and proposes an analytical model for the DVB‐RCS2 RA load control algorithm followed by performance assessment via numerical computations and simulations. Copyright © 2013 John Wiley & Sons, Ltd.
Influence of a laser profile in impedance mismatch techniques applied to carbon EOS measurement
Authors: Aliverdiev A. , Batani D. , Dezulian R. 
Published: August 2013

AbstractWe present a recent numerical analysis of impedance mismatch technique applied to carbon equation of state measurements. We consider high-power laser pulses with a Gaussian temporal profile of different durations. We show that for the laser intensity (${\approx }1{0}^{14} ~\mathrm{W} / {\mathrm{cm} }^{2} $) and the target design considered in this paper we need to have laser pulses with rise-time less than 150 ps.
Deformation and breakup of a leaky dielectric drop in a quadrupole electric field
Authors: Deshmukh Shivraj D. , Thaokar Rochish M. 
Published: August 2013

AbstractThe deformation and breakup of a leaky dielectric drop suspended in a leaky dielectric medium subjected to a quadrupole electric field are studied. Analytical (linear and nonlinear asymptotic expansions in the electric capillary number, $C{a}_{Q} $, a ratio of electric to capillary stress) and numerical (boundary element) methods are used. A complete phase diagram for the drop deformation in the $R$–$Q$ plane is presented, where $R$ and $Q$ are the non-dimensional ratios of the resistivities and dielectric constants, respectively, of the drop and the medium phase. The prolate and oblate deformations are mapped in the phase diagram, and the flow contours are also shown. The large deformation and breakup of a drop at higher $C{a}_{Q} $ are analysed using the boundary element method. Several non-trivial shapes are observed at the onset of breakup of a drop. A prolate drop always breaks above a certain critical value of $C{a}_{Q} $. In the oblate deformation cases, breakup as well as steady shapes are observed at a higher value of $C{a}_{Q} $. A detailed study of prolate and oblate deformation tendencies due to the normal and tangential electric stresses and the countervailing role of viscous stresses is presented. The circulation inside a drop is found to be more intense for a quadrupole field as compared with a uniform electric field. More intense internal circulations can lead to enhanced mixing characteristics and will have implications in microfluidic devices.
Dynamics of nearly spherical bubbles in a turbulent channel upflow
Authors: Lu Jiacai , Tryggvason Gretar 
Published: August 2013

AbstractThe dynamics of bubbles in upflow, in a vertical channel, is examined using direct numerical simulations (DNS), where both the flow and the bubbles are fully resolved. Two cases are simulated. In one case all the bubbles are of the same size and sufficiently small so they remain nearly spherical. In the second case, some of the small bubbles are coalesced into one large bubble. In both cases lift forces drive small bubbles to the wall, removing bubbles from the channel interior until the two-phase mixture is in hydrostatic equilibrium, and forming a bubble-rich wall layer. The same evolution has been seen in earlier DNS of bubbly upflows, but here the friction Reynolds number is higher (${\mathit{Re}}^{+ } = 250$). In addition to showing that the overall structure persists at higher Reynolds numbers, we show that the bubbles in the wall layer form clusters. The mechanism responsible for the clustering is explained and how bubbles move into and out of the wall layer is examined. The dynamics of the bubbles in the channel core is also compared with results obtained in fully periodic domains and found to be similar. The presence of the large bubble disrupts the wall layer slightly, but does not change the overall picture much, for the parameters examined here.
The Round Temple in the Forum Boarium
Authors: Strong D. E. , Ward-Perkins J. B. 
Published: August 2013

The name and date of the little round temple in the Forum Boarium at Rome (popularly known as the ‘Temple of Vesta’) are long-standing problems of Roman topography. Its identification is still quite uncertain. On the chronology, however, general opinion seems to have hardened and, for reasons which are discussed below, most scholars appear now to believe that the building is Augustan, rejecting the attractive theory of Altmann and Delbrueck that it was erected some time in the later second century B.C. The present article is not concerned at all with the problem of identification, nor does it attempt the full and detailed study of the design and construction without which a definitive solution of the problem of dating is clearly impossible. Its purpose is twofold: to draw attention to some significant features of the architectural design and decoration, and to illustrate and discuss some surviving fragments which can be shown to belong to the lost entablture, but which seem hitherto to have escaped attention.The foundations of the temple were first exposed by Valadier in the early nineteenth century, in the course of restoration work undertaken to free the building of later accretions and to consolidate the ancient remains.