bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doing youth in time? A relational perspective on the temporal constructions of youth
Authors: Walther Andreas , Stauber Barbara 
Published: July 2024

Temporality is a key principle of the constitution of youth as a life phase. Historically, ,invented‘ and institutionalized as moratorium, youth has been reserved for preparation for adulthood, thus contributing to the sequential order of the modern life course. Institutional age marks in school, youth welfare or citizenship claim to explicitly demarcate beginning and ending of youth in a linear way. Not only but most lately in the context of the activating welfare state, temporal normativities and normalities of growing up seem to have lost consistency. Consequently, young people have to position themselves with regard to chrononormative markers of the ‘right age’ reflected by distinctions from, ‘too young for …’ or, ‘too old for …’. The article analyses blurring temporalities of the youth phase by relating changes of the temporal regime(s) of young people's growing up and their individual and collective time work from a doing transitions perspective. The complexity and paradox of these temporalities are illustrated by three exemplary empirical case vignettes: Coping with suspended transitions in the pandemic; Fridays for Future as intergenerational struggle for future; and youth cultural practices expressing attempts of slowing down. In these constellations tensions of temporality emerge: the tension between moratorium and acceleration, between orientation towards the future and orientation towards the present, between simultaneity and linear sequentiality. A relational approach to the temporalities of youth is developed along with concepts like relative time and asynchronicity while young people's time work is reinterpreted in terms of doing youth in time. The paper concludes by discussing the implications of relational temporality for conceptualizing young people's agency and consequences for youth research.
Do ethical views of end-of-life patients’ family members impact organ donation decisions?
Authors: Aksoy Berna , Kasıkcı Turker Esengul 
Published: July 2024

Background: The relatives of patients who decide to donate their loved one’s organs experience dilemmas about organ donation and are affected by culture, religion, and individual views. Aim: The aim of this study was to determine the relationship between the ethical position and personal characteristics of the family members of the patients receiving end-of-life care and their thoughts about organ donation in Turkey. Research design and participants: The study was completed with 158 family members. For data collection, a personal information form and the Ethics Position Questionnaire were used. Ethical considerations: This study was obtained from the ethics committee of the faculty of medicine in Turkey. It was based on voluntary participation, informed consent, confidentiality, and anonymity. Results: All participants in the study shared the same faith and were Muslims. The idealism and relativism tendencies of the participants tended to be high. The number of children, the participants have, participants’ status of waiting for an organ transplant, the view that the clergy and health personnel will increase interest in organ donation were identified as factors associated with idealism tendencies. Participants’ status of having children, the number of children participants have, participants’ status of organ transplant waiting, the view that the health personnel will increase interest in organ donation were identified as factors associated with relativism tendencies ( p < 0.0.5). Conclusion: The results of this study demonstrated a relationship between participants’ idealism and relativism tendencies, among those with a large number of children, waiting for organ donation, advocating for clergy guidance to increase organ donations, and believing healthcare professionals need not guide to increase organ donations. In light of this finding, it may be recommended to establish a multidisciplinary team, including healthcare professionals and clergy, and to inform the society with accurate information to increase the number of organ donations.
Multidisciplinary Velopharyngeal Dysfunction Evaluation Helps Detect Non-classic Cases of 22q11.2 Deletion
Authors: Stanek Krystof , Wang Alice T. , Hseu Anne F. , Clark Roseanne E. , Meara John G. , Nuss Roger C. , Ganske Ingrid M. , Rogers-Vizena Carolyn R. 
Published: July 2024

Objective To explore the role of multidisciplinary velopharyngeal dysfunction (VPD) assessment in diagnosing 22q11.2 deletion syndrome (22q) in children. Design Retrospective cohort study. Setting Multidisciplinary VPD clinic at a tertiary pediatric hospital. Patients, Participants Seventy-five children with genetically confirmed 22q evaluated at the VPD clinic between February 2007 and February 2023, including both previously diagnosed patients and those newly diagnosed as a result of VPD evaluation. Interventions Comprehensive review of medical records, utilizing ICD-10 codes and an institutional tool for keyword searches, to identify patients and collect data on clinical variables and outcomes. Main Outcome Measures Characteristics of children with 22q, pathways to diagnosis, and clinical presentations that led to genetic testing for 22q. Results Of the 75 children, 9 were newly diagnosed with 22q following VPD evaluation. Non-cleft VPI was a significant indicator for 22q in children not previously diagnosed, occurring in 100% of newly diagnosed cases compared to 52% of cases with existing 22q diagnosis ( P = .008). Additional clinical findings leading to diagnosis included congenital heart disease, craniofacial abnormalities, and developmental delays. Conclusions VPD evaluations, particularly the presence of non-cleft VPI, play a crucial role in identifying undiagnosed cases of 22q. This underscores the need for clinicians, including plastic surgeons, otolaryngologists, and speech-language pathologists, to maintain a high degree of suspicion for 22q in children presenting with VPI without a clear etiology. Multidisciplinary approaches are essential for early diagnosis and management of this complex condition.
Influence of nonlinear motor suspension parameters on Hopf bifurcation characteristics of high-speed bogie
Authors: Huang Yu , Dai Huanyun , Shi Huailong , Huang Caihong , Qi Yayun , Mao Rancheng , Shi Wen 
Published: July 2024

A dynamic model of the bogie was established to investigate the influence of the elastic suspension of the motor and some nonlinear terms on the stability of vehicle hunting motion. Linear analysis was conducted based on the root locus method and other methods, and the influence of the elastic suspension of the motor on the linear critical speed was studied. Then, based on research on linear stability, the impact of the first Lyapunov coefficient of the model on the Hopf bifurcation type was analyzed. Subsequently, the influence of the stiffness and damping cubic terms in the motor suspension on the first Lyapunov coefficient was studied, and the possibility of controlling the Hopf bifurcation type by changing the stiffness and damping cubic terms in the motor suspension was analyzed, and relevant research was conducted. The results show that the increase of the cubic term of stiffness increased the corresponding speed when the amplitude of the limit cycle was 8 mm by about 3.4 km/h, and the increase of the cubic term of damping increased the corresponding speed when the amplitude of the limit cycle was 8 mm by about 8.9 km/h. Finally, a time-domain diagram corresponding to systems with different motor suspension stiffness and damping cubic terms was presented, further explaining the role of the motor suspension cubic terms and conducting relevant validation, providing reference opinions for the design of the motor elastic suspension of multiple units.
Evaluating the efficacy of a premedication regimen including high-dose cetirizine in reduction of hypersensitivity reactions to paclitaxel: A retrospective cohort study
Authors: Hutchinson Alexander , Weaver Kelly , Gunaratnam Bakeerathan , Volz Lesley , Ingles Lauren , Figg Lindsay 
Published: July 2024

Introduction Hypersensitivity reactions (HSR) are a known adverse effect of paclitaxel, occurring in approximately 10% of patients, typically during the first or second infusion of the medication. Corticosteroids, histamine-1 and histamine-2 receptor antagonists are given prior to paclitaxel infusions to reduce the incidence of HSR. There are limited data that suggest administration of cetirizine given prior to a platinum infusion as secondary prophylaxis may reduce HSR rates. Methods The objective of this study was to assess the impact of a novel paclitaxel hypersensitivity prevention protocol including high-dose cetirizine administered 12 and 6 h prior to paclitaxel infusion on the rate of HSR compared to a historical control. The primary objective was the rate of HSR of any grade after the first cycle of paclitaxel. Secondary outcomes included grade of infusion reaction and incidence of severe HSR. Results A total of 104 patients were included for analysis in the cetirizine group and 124 in the control group. Hypersensitivity reactions occurred in 37 (16.2%) patients in the overall population, and no statistical difference was observed between groups. (13.46% vs 18.55%; p = 0.23). Numerically more grade 3–4 HSRs occurred in the control group than the treatment group (30.77% vs 69.23; p = 0.51). Conclusions The addition of cetirizine to paclitaxel infusions resulted in numerically lower rates of HSR and a reduction in severity of grade 3–4 HSRs. Future studies with more robust compliance data and a larger patient population would be needed to appropriately assess the efficacy of our novel treatment regimen.
Determinants of clinic absenteeism in a chemotherapy service of a cancer center located at Rio de Janeiro, Brazil
Authors: Serra-Campos Amanda Oliveira , Soares Filipe dos Santos , Barreto Elizangela Domiciano Garcia , Magliano Erika da Silva 
Published: July 2024

Introduction Clinic absenteeism promotes higher waiting lists for medical procedures and public resources waste. Objectives The present work aimed to identify the reasons for clinic absenteeism from each cycle of the antineoplastic chemotherapy treatment, as well as to determine the socio-demographic, clinical and treatment profiles of this population. Methods This observational prospective work evaluated pediatric and adult patients which missed their chemotherapy cycle between May and October 2023 in a Cancer Center located in Rio de Janeiro, Brazil. Clinic absenteeism rate was calculated, and socio-demographic profile was described. Reasons for absenteeism, treatment protocol and most used drugs were also identified. Results This work analyzed data from 69 patients, the majority above 60 years old. Approximately 60% were male, 33.3% had little to no education and 63.8% lived outside the center city. Absenteeism average monthly rate was 1.73% for adults and 0.87% for children. The most related non-attendance reasons were patient feeling too ill to attend their chemotherapy session, failure to remember the cycle day and lack of means of transportation. Most prevalent neoplasms were from the digestive tract (46%). Fluorouracil, irinotecan, oxaliplatin and gemcitabine were the most discarded drugs due to absenteeism. Conclusions Older patients and the ones residing far away from the Center tend to miss the scheduled chemotherapy cycles. However, most reasons for absenteeism could be avoided by confirmation calls or text messages. These procedures implementation could lead to a lower absenteeism rate and less resource waste.
Severe neutropenia probably caused by enzalutamide and abiraterone in a prostate cancer patient
Authors: Somoza-Fernández Beatriz , Escudero-Vilaplana Vicente , Collado-Borrell Roberto , Pérez-Ramírez Sara , Villanueva-Bueno Cristina , Montero-Antón María del Pilar , Herranz-Alonso Ana , Sanjurjo-Saez María 
Published: July 2024

Introduction Abiraterone and enzalutamide are two androgen receptor pathway inhibitors approved, among others, for the treatment of metastatic castration-resistant prostate cancer in adult men whose disease has progressed on or after a docetaxel-based regimen. Although hematological effects, especially neutropenia, are one of the main complications of other oral antineoplastic drugs, these adverse effects are infrequent in the case of androgen receptor pathway inhibitors. Case report We report the case of a patient diagnosed with metastatic castration-resistant prostate cancer who discontinued an androgen receptor pathway inhibitor due to drug-related grade 4 neutropenia. His control blood counts before enzalutamide starting were normal. After one month of treatment, he developed a grade 4 neutropenia, with complete neutrophil count recovery four weeks later. He underwent a bone marrow aspiration, which revealed normocelullar results, and enzalutamide was restarted. Three weeks later, the treatment was eventually discontinued due to neutropenia reappearance. Neutrophil count recovery was achieved one month later. Then, he started treatment with abiraterone, but two weeks later neutropenia reappeared. Abiraterone was withdrawn, and the patient recovered from neutropenia 2 weeks later. Management and outcomes This case exposes not only the occurrence of rare toxicity of two individual drugs but also the description of a probable drug-class adverse event not reported before. The patient recovered from neutropenia after the androgen receptor pathway inhibitor was withdrawn, thereby supporting the diagnosis of probable drug-induced neutropenia. Discussion There is scarce evidence in the literature concerning androgen receptor pathway inhibitor-related neutropenia. However, its life-threatening potential cannot be ignored, so healthcare professionals should be warned of the possibility of the occurrence of such adverse reactions.
Social workers in schools: A feasibility study of three local authorities
Authors: Westlake David , Melendez-Torres G.J. , Corliss Cindy , El-Banna Asmaa , Thompson Sarah , Meindl Melissa , Talwar Ria , Folkes Louise , Schoenwald Eva , Addis Samia , Cook Laura 
Published: July 2024

Summary This study evaluated the feasibility of ‘Social Workers in Schools’, an intervention that involved social workers being based within schools across three local authorities in England (SWIS). Schools make a large number of referrals to Children's Social Care and play an important role in recognizing risks to children and protecting them from harm, but it is unusual for social workers to be based in schools in the U.K. and to do statutory work. We evaluated the pilots on the basis of the feasibility of implementing SWIS, how promising it was in terms of reducing the need for statutory intervention, and the extent to which it be scaled. We used a mixed methods approach, with a process evaluation and a difference in differences analysis of indicative impact on key social care outcomes. In addition, we estimated the cost of implementing and maintaining SWIS. Findings We found high levels of acceptability among those involved, and examples of how SWIS enhances the way safeguarding issues are addressed. There was also some evidence that it may reduce the need for social care interventions, though this needs ratifying with more and better data. Applications The study suggests that SWIS is a promising intervention. Both the qualitative and quantitative findings suggest it may have the intended policy impact, but this needs to be tested on a larger scale and with a more rigorous counterfactual comparison. Such a study—a randomized-controlled trial involving 21 local authorities—was commissioned in 2020.
Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative Radiotherapy
Authors: Lang Kristin , Held Thomas , Freudlsperger Christian , Plath Karim , Hoffmann Jürgen , Plinkert Peter K. , Debus Jürgen , Adeberg Sebastian 
Published: July 2024

Introduction Postoperative radiotherapy can improve locoregional control (LC) in oral cavity squamous cell carcinoma (OCSCC) patients with positive resection margins. The present study aimed to evaluate the impact of surgical margin size on LC in this patient population. Methods This retrospective study involved 162 patients with OCSCC who underwent postoperative radiotherapy between 2000 and 2020 at the Department of Radiation Oncology, University Hospital Heidelberg and the German Cancer Research Center. The study aimed to determine the impact of different resection margins on LC, as well as overall survival (OS), progression-free survival (PFS), and treatment-related toxicity (CTCAE 4.03). Results Seventy-seven patients (47.5%) had involved (<1 mm) margins, 22 patients (13.6%) close (≤5 mm) margins, and 63 patients (38.9%) clear (>5 mm) margins. A surgical margin ≤ 5 mm was a significant predictor for worse LC (HR 2.6, 95% CI 1.2, 6.1), but not for OS (HR 1.2, CI 0.7, 1.9) or PFS (HR 1.2, 0.7, 2.0). Conclusion Patients who have narrow resection margins (1-5 mm) experience poor local control and should receive postoperative radiotherapy. It is necessary to conduct further prospective studies to determine whether a narrower margin window could be achieved to better determine the appropriate indication for adjuvant radiotherapy.
Efficacy and Safety Analysis of Recombinant Human Endostatin (Endostar) Combined With Chemoradiotherapy for Locally Advanced Cervical Cancer: A 2-Center Retrospective Study
Authors: Feng Yue , Li Xin , Sun Fei , Zhou Juying , Wang Lili , Zeng Hongwei , Yu Jingping 
Published: July 2024

Background This study aims to assess the efficacy and safety of Endostar in the management of locally advanced cervical cancer. Methods This retrospective, 2-center study enrolled 41 patients with locally advanced cervical cancer between June 2017 and December 2020. The patients were subjected to a combination of Endostar and chemoradiotherapy until they experienced disease progression or an unacceptable level of toxicity. The patients in the Endostar combined chemoradiotherapy (E + CRT) and CRT groups were matched 1:1 based on clinical features, including age, disease stage, and pathological type. The therapeutic efficacy and safety outcomes were compared between the 2 groups. Results Early treatment response: the CR rates in E + CRT and CRT groups were 48.8% and 26.8%, respectively ( χ2 = 4.20, P < .05). The ORR and DCR were not significantly different between the 2 groups. Long-term efficacy: there was no significant difference in the 1-year and 2-year PFS rates and OS rates between 2 groups. However, in patients with stage IIB, subgroup analyses revealed a significant difference in PFS between the 2 groups ( P < .05). Prognostic factors: stage, Eastern Cooperative Oncology Group (ECOG) score, and tumor size were independent predictive factors for PFS, while ECOG score and tumor size were those of OS in patients with locally advanced cervical cancer. Safety: The incidence of grade III-IV myelosuppression was significantly lower in E + CRT group than in CRT group ( P < .05). Conclusions The combination of Endostar and concurrent CRT exhibited greater efficacy in treating locally advanced cervical cancer with no severe adverse reactions, when compared to simple CRT. It is expected that this approach will evolve into a new treatment alternative for patients with locally advanced cervical cancer.
Selective brain cooling with a novel catheter reduces infarct growth after recanalization in a canine large vessel occlusion model
Authors: King Robert M , Anagnostakou Vania , Shazeeb Mohammed Salman , Hornibrook Shannon , Mitchell Jennifer , Epshtein Mark , Raskett Christopher , Henninger Nils , Puri Ajit S , Merrill Thomas L , Gounis Matthew J 
Published: July 2024

Background Therapeutic hypothermia has shown potential in cardiac intervention for years; however, its adoption into the neurovascular space has been limited. Studies have pointed to slow cooling and limited depth of hypothermia yielding negative outcomes. Here we present an insulated catheter that allows for consistent infusion of chilled saline directly to the brain. Direct delivery of cold saline allows a faster depth of hypothermia, which could have a benefit to the growth of ischemic lesions. Methods Ten canines were randomized to either receive selective brain cooling or no additional therapy. Eight animals were successfully enrolled (n = 4 per group). Each animal underwent a temporary middle cerebral artery occlusion (MCAO) for a total of 45 min. Five minutes prior to flow restoration, chilled saline was injected through the ipsilateral internal carotid artery using an insulated catheter to ensure delivery temperature. The treatment continued for 20 min, after which the animal was transferred to an MRI scanner for imaging. Results Of the 8 animals that were successfully enrolled in the study, 3 were able to survive to the 30-day endpoint with no differences between the cooled and control animals. There was no difference in the initial mean infarct size between the groups; however, animals that did not receive cooling had infarcts continuing to progress more rapidly after the MCAO was removed (13.8% vs 161.3%, p = 0.016, cooled vs control). Conclusions Selective hypothermia was able to reduce the post-MCAO infarct progression in a canine model of temporary MCAO.
“I Felt Like I Mattered”: Caring is a key ingredient of collaborative care for chronic illness
Authors: Graney Bridget A , Portz Jennifer Dickman , Bekelman David B 
Published: July 2024

Objectives To identify perceptions and experiences related to caring science and collaborative care in intervention participants of the Collaborative Care to Alleviate Symptoms and Adjust to Illness (CASA) study, a randomized, multi-site clinical trial for patients with chronic heart failure and reduced health status. Methods Forty-five participants completed semi-structured, telephone interviews with a focus on intervention components, impact of the intervention on participants’ lives, and recommendations for intervention change. Data were analyzed using an inductive content analysis approach focusing on the presence and frequency of text to identify patterns, categories, and themes across participants without an a priori code book. The validity of the identified categories was enhanced through triangulation. Results Three themes were identified: (1) intervention providers’ caring/helping attitude and caring/helping communication; (2) care team availability to respond to concerns or questions; and (3) help with understanding and navigating the healthcare system. Discussion Patients highly value caring attitudes and communication, availability, and empowerment to understand and navigate healthcare systems. These attitudes and behaviors may be important mediators of the success of collaborative care programs. These are consistent with the theory of caring science, a framework that is relevant more broadly to patient-centered and team-based care models.