bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-invasive respiratory support in children and young adults with complex medical conditions in pediatric palliative care
Authors: Fauroux Brigitte , Taytard Jessica , Ioan Iulia , Lubrano Marc , Le Clainche Laurence , Bokov Plamen , Dudoignon Benjamin , Debelleix Stephane , Galode Francois , Coutier Laurianne , Sigur Elodie , Labouret Geraldine , Ollivier Morgane , Binoche Alexandra , Bergougnioux Jean , Mbieleu Blaise , Essid Aben , Hullo Eglantine , Barzic Audrey , Moreau Johan , Jokic Mikael , Denamur Sophie , Aubertin Guillaume , Schweitzer Cyril 
Published: July 2024

ObjectiveDyspnoea and sleep-disordered breathing (SDB) are common in children with life-limiting conditions but studies on treatment with non-invasive ventilation (NIV) or continuous positive airway pressure (CPAP) are scarce. The aim of the study was to describe children treated with long-term NIV/CPAP within a paediatric palliative care programme in France.MethodsCross-sectional survey on children and young adults with complex medical conditions treated within the French paediatric NIV network with long-term NIV/CPAP. Characteristics of the patients were analysed and patient-related outcome measures of NIV/CPAP benefit were reported.ResultsThe data of 50 patients (68% boys), median age 12 (0.4–21) years were analysed. Twenty-three (46%) patients had a disorder of the central nervous system and 5 (10%) a chromosomal anomaly. Thirty-two (64%) patients were treated with NIV and 18 (36%) with CPAP. NIV/CPAP was initiated on an abnormal Apnoea-Hypopnoea Index in 18 (36%) of the patients, an abnormal nocturnal gas exchange alone in 28 (56%), and after an acute respiratory failure in 11 (22%) of the patients. Mean objective NIV/CPAP adherence was 9.3±3.7 hours/night. NIV/CPAP was associated with a decrease in dyspnoea in 60% of patients, an increase in sleep duration in 60% and in sleep quality in 74%, and an improvement in parents’ sleep in 40%.ConclusionsIn children with life-limiting conditions, long-term NIV/CPAP may be associated with relief of dyspnoea, an improvement of SDB and an improvement in parents’ sleep.
Associations between device-measured and self-reported physical activity and common mental disorders: Findings from a large-scale prospective cohort study
Authors: Wang Zhe , Cao Zhi , Min Jiahao , Duan Tingshan , Xu Chenjie 
Published: July 2024

ObjectivesTo investigate the associations between device-measured and self-reported physical activity (PA) and incident common mental disorders in the general population.Design and settingLarge-scale prospective cohort study.ParticipantsUsing the UK Biobank data, a validated PA questionnaire was used to estimate self-reported weekly PA in 365 656 participants between 2006 and 2010 while 91 800 participants wore wrist-worn accelerometers for 7 days in 2013–2015 to derive objectively measured PA. All the participants were followed up until 2021.Main outcome measuresIncidences of depression and anxiety were ascertained from hospital inpatient records. Cox proportional hazards models and restricted cubic splines were used to assess the associations between subjectively and objectively measured PA and common mental disorders.ResultsDuring a median follow-up of 12.6 years, 16 589 cases of depression, 13 905 cases of anxiety and 5408 cases of comorbid depression and anxiety were documented in the questionnaire-based cohort. We found J-shaped associations of self-reported PA with incident risk of depression and anxiety, irrespective of PA intensities. The lowest risk for depression occurred at 550, 390, 180 and 560 min/week of light-intensity PA (LPA), moderate-intensity PA (MPA), vigorous-intensity PA (VPA) and moderate-to-vigorous PA (MVPA), respectively. During a median follow-up of 6.9 years, a total of 2258 cases of depression, 2166 cases of anxiety and 729 cases of comorbid depression and anxiety were documented in the accelerometer-based cohort. We found L-shaped associations of device-measured MPA and VPA with incident depression and anxiety. MPA was adversely associated with incident depression and anxiety until 660 min/week, after which the associations plateaued. The point of inflection for VPA occurred at 50 min/week, beyond which there was a diminished but continued reduction in the risks of depression and anxiety.ConclusionDifferent patterns of associations between self-reported and device-measured PA and mental health were observed. Future PA guidelines should fully recognise this inconsistency and increasingly employ objectively measured PA standards.
Investigating the Temperature Dependency of Trimethyl Aluminum Assisted Atomic Surface Reduction of Li and Mn-Rich NCM
Authors: Evenstein Eliran , Taragin Sarah , Saha Arka , Noked Malachi , Rosy  
Published: July 2024

Most next-generation electrode materials are prone to interfacial degradation, which eventually spreads to the bulk and impairs electrochemical performance. One promising method for reducing interfacial degradation is to surface engineer the electrode materials to form an artificial cathode electrolyte interphase as a protective layer. Nevertheless, the majority of coating techniques entail wet processes, high temperatures, or exposure to ambient conditions. These experimental conditions are only sometimes conducive and can adversely affect the material structure or composition. Therefore, we investigate the efficacy of a low-temperature, facile atomic surface reduction (ASR) using trimethylaluminum vapors as a surface modification strategy for Li and Mn-rich NCM (LMR-NCM). The results presented herein manifest that the extent of TMA-assisted ASR is temperature-dependent. All tested temperatures demonstrated improved electrochemical performance. However, ASR carried out at temperatures >100 °C was more effective in preserving the structural integrity and improving the electrochemical performance. Electrochemical testing revealed improved rate capabilities, cycling stability, and capacity retention of ASR-treated LMR-NCM. Additionally, post-cycling high-resolution scanning electron microscopy analysis verified that after extended cycling, ASR carried out at T > 100 °C showed no cracks or cleavage, demonstrating the efficiency of this method in preventing surface degradation.
An Amperometric Type NO2 Sensor Utilizing La0.7Sr0.3MnO3−δ
-NiO Composite Sensing Electrode
Authors: Zhao Tengteng , Wang Chaoyu , Dai Lei , Meng Weiwei , Liu Yongguang , Li Yuehua , Wang Ling 
Published: July 2024

NO2 is an important pollutant of automobile engines and industrial fuels, making it important to quantitatively monitor and control. An amperometric-type NO2 gas sensor was fabricated using yttria-stabilized zirconia (YSZ) electrolyte with a bi-layered structure and La0.7Sr0.3MnO3−δ
-xNiO (LSMO-xNiO, x = 0–0.75) composite sensing electrode (SE) prepared by impregnation method in combination with self-demixing. The samples were characterized using SEM, XRD, and XPS, and their performance as sensors was tested. LSMO-xNiO composite SE particles were formed by de-mixing in the process of treating the precursor at high temperatures and are uniformly dispersed in the YSZ porous backbone. With the increase of NiO content, the SE particles become significantly large. At 450 °C–600 °C, the response currents at a fixed potential have a linear relationship with the NO2 concentrations at 25–700 ppm. Combining stability and sensitivity, the voltage was fixed to −0.25 V. The introduction of NiO into the LSMO sensing electrode effectively improves the performance of the sensor. The sensor based on LSMO-0.5NiO has the highest sensitivity (0.0405 μA/ppm) at 550 °C. Simultaneously, the sensor exhibits good anti-interference ability for CH4, CO2, O2, and NO, but has obvious cross-sensitivity to H2 and NH3. In addition, the response current of the sensor change with the increase of RH.
A Novel Electrochemical Sensing Based on Cerium Oxide/Nitrogen-Doped Reduced Graphene Oxide for Sensitive Detection of Acetaminophen
Authors: Qi Xue , Wang Ziyin , Yuan Honglin , Gao Hongmin , Ren Xinshui , Chen Hua , Zhang Hehua , Chang Dong , Pan Hongzhi 
Published: July 2024

Acetaminophen (ACP), a common analgesic and antipyretic medication, can harm the liver when overdosed and its metabolites can contaminate the environment, so it is necessary to monitor the concentration precisely and reliably. In this work, we successfully synthesized cerium oxide/nitrogen-doped reduced graphene oxide (CeO2/N-rGO) composite nanomaterials using a one-step hydrothermal method. Using composite nanomaterials, we created an electrochemical sensing detection platform for ACP detection. The synthesized materials were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy. The constructed electrochemical sensor exhibits good ACP detection ability under the synergistic effect of CeO2 and N-rGO. Under optimal experimental conditions, the sensor displayed a linear range for the detection of ACP of 1 ∼ 200 μM and the lowest detection limit of 0.79 μM, exhibiting outstanding selectivity, stability, and repeatability. Furthermore, the sensor was effectively applied to detect ACP in tap water samples, which offers a wide range of possible applications in actual sample testing.
Cancer History and Social Support Impact Colorectal Cancer Screening Utilization by Race/Ethnicity
Authors: Tsai Meng-Han , Lee Minjee , Coughlin Steven S. , Eberth Jan M. , Rogers Charles R. 
Published: July 2024

Abstract
This study examined the association among cancer history, social support, and up-to-date colorectal cancer (CRC) screening among four racial/ethnic groups. We conducted a cross-sectional analysis using data on respondents aged 45 to 75 years from the 2022 Behavioral Risk Factor Surveillance System. Our outcome of interest was CRC screening and exposures of interest were race/ethnicity, cancer history, and social support. Weighted multivariable logistic regression was performed. Among 73,869 adults, the CRC screening rate was 66.8% with the highest rate in non-Hispanic (NH), Whites (72.2%), and the lowest in Hispanics (52.6%). Screening rates were higher in adults with a cancer history (81.9%) and those having social support (69%). Hispanic adults with a cancer history had lower screening use (50.9% vs. 77.4% in the no cancer history group; P value &lt; 0.001). Regardless of race/ethnicity, adults without social support had lower screening utilization (P value &lt; 0.05). In effect modification, NH White adults who reported no cancer history and lack of social support were 12% less likely to have CRC screening than those with social support but without cancer history (OR, 0.88; 95% confidence intervals, 0.79–0.98). Similar results were observed among Hispanic adults without a cancer history and social support, with 37% less likely to have CRC screening than those with social support but no cancer history (OR, 0.63; 95% confidence intervals, 0.42–0.93). NH White and Hispanic adults without a cancer history and limited social support were less likely to have CRC screening uptake. By implementing culturally tailored interventions that address social support needs, greater CRC screening compliance may be increased among these populations.
Prevention Relevance: Adherence to CRC screening recommendations reduces cancer incidence and mortality. Effective implementation of culturally tailored interventions that address social support needs and consider cancer history have the potential for improving CRC screening compliance among NH White and Hispanic adults without a cancer history.
Estimates of Baroclinic Tidal Sea Level and Currents from Lagrangian Drifters and Satellite Altimetry
Authors: Zaron Edward D. , Elipot Shane 
Published: July 2024

Abstract
Internal waves generated by the interaction of the surface tides with topography are known to propagate long distances and lead to observable effects such as sea level variability, ocean currents, and mixing. In an effort to describe and predict these waves, the present work is concerned with using geographically distributed data from satellite altimeters and drifting buoys to estimate and map the baroclinic sea level associated with the M2, S2, N2, K1, and O1 tides. A new mapping methodology is developed, based on a mixed L1/L2-norm optimization, and compared with previously developed methods for tidal estimation from altimeter data. The altimeter and drifter data are considered separately in their roles for estimating tides and for cross-validating estimates obtained with independent data. Estimates obtained from altimetry and drifter data are found to agree remarkably well in regions where the drifter trajectories are spatially dense; however, heterogeneity of the drifter trajectories is a disadvantage when they are considered alone for tidal estimation. When the different data types are combined by using geodetic mission altimetry to cross validate estimates obtained with either exact-repeat altimetry or drifter data, and subsequently averaging the latter estimates, the estimates significantly improve on the previously published HRET8.1 model, as measured by their utility for predicting sea level and surface currents in the open ocean. The methodology has been applied to estimate the annual modulations of M2, which are found to have much smaller amplitudes compared to those reported in HRET8.1, and suggest that the latter estimates of these tides were not reliable.

Significance Statement
The mechanical and thermodynamic forcing of the ocean occurs primarily at very large scales associated with the gravitational perturbations of the sun and moon (tides), atmospheric wind stress, and solar insolation, but the frictional forces within the ocean act on very small scales. This research addresses the question of how the large-scale tidal forcing is transformed into the smaller-scale motion capable of being influenced by friction. The results show where internal waves are generated and how they transport energy across ocean basins to eventually be dissipated by friction. The results are useful to scientists interested in mapping the flows of mechanical energy in the ocean and predicting their influences on marine life, ocean temperature, and ocean currents.
The Evolution of the 2021 Seacor Power Tragedy in Coastal Louisiana
Authors: Miller P. W. , Li C. , Xu K. , Caparotta S. , Rohli R. V. 
Published: July 2024

Abstract
On 13 April 2021, a mesoscale convective system (MCS) swept across the southeastern Louisiana coast, capsizing the 39-m Seacor Power roughly 7 km from shore and leaving 13 mariners drowned or missing. In addition to the severe straight-line winds that sank the vessel, sustained surface winds > 20 m s−1 behind the leading convection persisted well after the main convective band, inhibiting search and rescue efforts. Though complete historical fatality statistics are unavailable, the 13 deaths associated with this event likely represent one of the deadliest severe convective weather events in modern U.S. maritime history. This analysis integrates in situ, remotely sensed, and reanalysis datasets to reconstruct the 2021 Seacor Power accident as well as ascertain its depiction in day-of operational convection-allowing model (CAM) guidance. Results suggest that the MCS formed along an unanalyzed coastal boundary and developed a strong mesohigh to the east of the wreck as it moved offshore. The resulting zonally oriented pressure gradient directed stiff easterly winds over the wreck for several hours, even as the squall line had propagated well away from the coast. This multihour period of severe weather along the Louisiana coast was relatively well resolved by morning-of CAM guidance, providing optimism that future such events may be anticipated with the lead times required by vulnerable seacraft to reach safe harbor. Future severe convective weather watches containing marine zones might include a “marine” section detailing the potential sea conditions, analogous to the “aviation” section in current severe weather watches.
The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1
Authors: Chion Alain , Byrne Ciara , Atiq Ferdows , Doherty Dearbhla , Aguila Sonia , Fazavana Judicael , Lopes Patricia , Karampini Ellie , Amin Aamir , Preston Roger J. S. , Baker Ross I. , McKinnon Thomas A. J. , Zhu Shuhao , Gilbert James C. , Emsley Jonas , Jilma Bernd , O’Donnell James S. 
Published: July 2024

Abstract
Rondaptivon pegol (previously BT200) is a pegylated RNA aptamer that binds to the A1 domain of von Willebrand factor (VWF). Recent clinical trials demonstrated that BT200 significantly increased plasma VWF–factor VIII levels by attenuating VWF clearance. The biological mechanism(s) through which BT200 attenuates in vivo clearance of VWF has not been defined. We hypothesized that BT200 interaction with the VWF-A1 domain may increase plasma VWF levels by attenuating macrophage-mediated clearance. We observed that full-length and VWF-A1A2A3 binding to macrophages and VWF-A1 domain binding to lipoprotein receptor–related protein 1 (LRP1) cluster II and cluster IV were concentration-dependently inhibited by BT200. Additionally, full-length VWF binding to LRP1 expressed on HEK293T (HEK-LRP1) cells was also inhibited by BT200. Importantly, BT200 interacts with the VWF-A1 domain in proximity to a conserved cluster of 4 lysine residues (K1405, K1406, K1407, and K1408). Alanine mutagenesis of this K1405-K1408 cluster (VWF-4A) significantly (P &lt; .001) attenuated binding of VWF to both LRP1 clusters II and IV. Furthermore, in vivo clearance of VWF-4A was significantly (P &lt; .001) reduced than that of wild-type VWF. BT200 did not significantly inhibit binding of VWF-4A to LRP1 cluster IV or HEK-LRP1 cells. Finally, BT200 interaction with the VWF-A1 domain also inhibited binding to macrophage galactose lectin and the SR-AI scavenger receptor. Collectively, our findings demonstrate that BT200 prolongs VWF half-life by attenuating macrophage-mediated clearance and specifically the interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1. These data support the concept that targeted inhibition of VWF clearance pathways represents a novel therapeutic approach for von Willebrand disease and hemophilia A.
METASEED: a novel approach to full-length 16S rRNA gene reconstruction from short read data
Authors: Philip Melcy , Rudi Knut , Ormaasen Ida , Angell Inga Leena , Pettersen Ragnhild , Keeley Nigel B. , Snipen Lars-Gustav 
Published: July 2024

Abstract
Background
With the emergence of Oxford Nanopore technology, now the on-site sequencing of 16S rRNA from environments is available. Due to the error level and structure, the analysis of such data demands some database of reference sequences. However, many taxa from complex and diverse environments, have poor representation in publicly available databases. In this paper, we propose the METASEED pipeline for the reconstruction of full-length 16S sequences from such environments, in order to improve the reference for the subsequent use of on-site sequencing.

Results
We show that combining high-precision short-read sequencing of both 16S and full metagenome from the same samples allow us to reconstruct high-quality 16S sequences from the more abundant taxa. A significant novelty is the carefully designed collection of metagenome reads that matches the 16S amplicons, based on a combination of uniqueness and abundance. Compared to alternative approaches this produces superior results.

Conclusion
Our pipeline will facilitate numerous studies associated with various unknown microorganisms, thus allowing the comprehension of the diverse environments. The pipeline is a potential tool in generating a full length 16S rRNA gene database for any environment.
An altered uterine microbiota with endometrial hyperplasia
Authors: Ying Xue , Xu Gufeng , Wang Huiyun , Wang Yue 
Published: July 2024

Abstract
Background
Endometrial hyperplasia (EH) is a precursor to endometrial cancer, and the role of the microbiome in its development is unclear.

Results
The present study investigated the uterine microbiome in patients with benign uterine conditions and endometrial hyperplasia. A significant structural shift in the uterine microbiome of patients with endometrial hyperplasia compared to those with benign conditions was found. Delftia, Serratia and Stenotrophomonas were significantly enriched in endometrial hyperplasia samples and associated with the presence of endometrial hyperplasia.

Conclusions
The novel finding suggested that increased abundance of Delftia, Serratia and Stenotrophomonas is associated with the presence of endometrial hyperplasia. Further investigation is needed to determine the value of these microbes as biomarkers for endometrial hyperplasia.
Identification and functional analysis of long non-coding RNA (lncRNA) and metabolites response to mowing in hulless barley (Hordeum vulgare L. var. nudum hook. f.)
Authors: Bai Yixiong , He Jiaqi , Yao Youhua , An Likun , Cui Yongmei , Li Xin , Yao Xiaohua , Xiao Shanshan , Wu Kunlun 
Published: July 2024

Abstract
Background
Hulless barley (Hordeum vulgare L. var. nudum Hook. f.) is a significant cereal crop and a substantial source of forage for livestock. Long non-coding RNAs (lncRNAs) and metabolites play crucial roles in the nutrient accumulation and regeneration of hulless barley plants following mowing. The study aimed to identify differentially expressed lncRNAs and metabolites in hulless barley plants by analyzing transcriptomic and metabolomic datasets at 2 h, 24 h, and 72 h following mowing.

Results
The study revealed that 190, 90, and 438 lncRNA genes were differentially expressed at the 2 h, 24 h, and 72 h time points compared to the non-mowing control. We identified 14 lncRNA genes—11 downregulated and 3 upregulated—showing consistently significant differential expression across all time points after mowing. These differentially expressed lncRNAs target genes involved in critical processes such as cytokinin signaling, cell wall degradation, storage protein accumulation, and biomass increase. In addition, we identified ten differentially expressed metabolites targeting diverse metabolic pathways, including plant hormones, alkaloids, and flavonoids, before and after mowing at various time points. Endogenous hormone analysis revealed that cytokinin most likely played a crucial role in the regeneration of hulless barley after mowing.

Conclusions
This study created a comprehensive dataset of lncRNAs, metabolites, and hormones in hulless barley after mowing, revealing valuable insights into the functional characteristics of lncRNAs, metabolites, and hormones in regulating plant regeneration. The results indicated that cytokinin plays a significant role in facilitating the regeneration process of hulless barley after mowing. This comprehensive dataset is an invaluable resource for better understanding the complex mechanisms that underlie plant regeneration, with significant implications for crop improvement.