bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pandemic 2009 Influenza A (H1N1) virus infection in cancer and hematopoietic stem cell transplant recipients; a multicenter observational study.
Authors: Dignani Maria Cecilia , Costantini Patricia , Salgueira Claudia , Jordán Rosana , Guerrini Graciela , Valledor Alejandra , Herrera Fabián , Nenna Andrea , Mora Claudia , Roccia-Rossi Inés , Stecher Daniel , Carbone Edith , Laborde Ana , Efron Ernesto , Altclas Javier , Calmaggi Aníbal , Cozzi José 
Published: September 2014

Background: During March 2009 a novel Influenza A virus emerged in Mexico. We describe the clinical picture of the pandemic Influenza A (H1N1) Influenza in cancer patients during the 2009 influenza season.Methods: Twelve centers participated in a multicenter retrospective observational study of cancer patients with confirmed infection with the 2009 H1N1 Influenza A virus (influenza-like illness or pneumonia plus positive PCR for the 2009 H1N1 Influenza A virus in respiratory secretions). Clinical data were obtained by retrospective chart review and analyzed. Results: From May to August 2009, data of 65 patients were collected. Median age was 51 years, 57 % of the patients were female. Most patients (47) had onco-hematological cancers and 18 had solid tumors. Cancer treatment mainly consisted of chemotherapy (46), or stem cell transplantation (SCT) (16). Only 19 of 64 patients had received the 2009 seasonal Influenza vaccine. Clinical presentation included pneumonia (43) and upper respiratory tract infection (22). Forty five of 58 ambulatory patients were admitted. Mechanical ventilation was required in 12 patients (18%). Treatment included oseltamivir monotherapy or in combination with amantadine for a median of 7 days. The global 30-day mortality rate was 18%. All 12 deaths were among the non-vaccinated patients. No deaths were observed among the 19 vaccinated patients. Oxygen saturation <96% at presentation was a predictor of mortality (OR 19.5; 95%CI: 2.28 to 165.9).Conclusions: In our cancer patient population, the pandemic 2009 Influenza A (H1N1) virus was associated with high incidence of pneumonia (66%), and 30-day mortality (18.5%). Saturation <96% was significantly associated with death. No deaths were observed among vaccinated patients.
Supplementary Education Center as a Multifunctional Centre for Applied Qualifications Oriented at the Regional Market Needs
Authors: Пахомова  , Pakhomova E. , Лаптева  , Lapteva I. , Липатова  , Lipatova S. , Сафонов  , Safonov V. , Кропочев  , Kropochev V. 
Published: September 2014

Based on theoretic and practical aspects, the authors feature how the Supplementary Education Center operates as a center for developing applied
qualifications oriented at the regional labor market needs.
Classifying Skills for Development of the 5th–6th-Classes Students’ Mathematical Capabilities Within the Numeric Line Format
Authors: Виситаева  , Visitaeva Maret 
Published: September 2014

The author has developed the method to classify skills, underpinning mathematical capabilities development among the 5th–6th-classes students, which
facilitate studying mathematics for the numeric line. The classification consists of two blocks, separately for basic and for advanced study, namely:
familiarity with the basic skills and methods for general learning activities; familiarity with methods of creative learning activity; operating with decimal
numeric system, with numerical and literal expressions, with common fractions, decimal fractions, positive and negative numbers, percents, arithmetic
mean), having skills to identify divisibility and skills to solve equations.
The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation
Authors: Abot Anne , Fontaine Coralie , Buscato Mélissa , Solinhac Romain , Flouriot Gilles , Fabre Aurélie , Drougard Anne , Rajan Shyamala , Laine Muriel , Milon Alain , Muller Isabelle , Henrion Daniel , Adlanmerini Marine , Valéra Marie‐Cécile , Gompel Anne , Gerard Céline , Péqueux Christel , Mestdagt Mélanie , Raymond‐Letron Isabelle , Knauf Claude , Ferriere François , Valet Philippe , Gourdy Pierre , Katzenellenbogen Benita S , Katzenellenbogen John A , Lenfant Françoise , Greene Geoffrey L , Foidart Jean‐Michel , Arnal Jean‐François 
Published: September 2014

AbstractEstetrol (E4) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand‐binding domain bound to 17β‐estradiol (E2) and E4 are very similar, as well as their capacity to activate the two activation functions AF‐1 and AF‐2 and to recruit the coactivator SRC3. In vivo administration of high doses of E4 stimulated uterine gene expression, epithelial proliferation, and prevented atheroma, three recognized nuclear ERα actions. However, E4 failed to promote endothelial NO synthase activation and acceleration of endothelial healing, two processes clearly dependent on membrane‐initiated steroid signaling (MISS). Furthermore, E4 antagonized E2 MISS‐dependent effects in endothelium but also in MCF‐7 breast cancer cell line. This profile of ERα activation by E4, uncoupling nuclear and membrane activation, characterizes E4 as a selective ER modulator which could have medical applications that should now be considered further.
High GADA titer increases the risk of insulin requirement in LADA patients: a 7-year follow-up (NIRAD study 7)
Authors: Zampetti Simona , Campagna Giuseppe , Tiberti Claudio , Songini Marco , Arpi Maria Luisa , De Simone Giuseppina , Cossu Efisio , Cocco Lorenzo , Osborn John , Bosi Emanuele , Giorgino Francesco , Spoletini Marialuisa , Buzzetti Raffaella , _ _ 
Published: September 2014

ObjectiveThe aim of this study was to determine whether glutamic acid decarboxylase antibody (GADA) titer and other clinical parameters could define the risk of progression to insulin therapy in latent autoimmune diabetes in adults (LADA) patients during a 7-year follow-up.MethodsThis study involved 220 LADA and 430 type 2 diabetes subjects followed up for 7 years from the time of GADA screening to evaluate their progression toward insulin therapy. Kaplan–Meier curves and multivariate logistic regression analysis were performed to identify the markers capable of influencing this progression.ResultsDuring the follow-up, the drop out was 4% in both groups. A total of 119 (56.1%) out of 212 LADA patients required insulin during the 7 years of follow-up. The Kaplan–Meier plots showed that 74/104 (71.1%) of high GADA titer required insulin compared with 45/108 (41.6%) of low GADA titer and with 86/412 (20.9%) of type 2 diabetes (P<0.0001 for both). A BMI of ≤25 kg/m2and IA-2ICand zinc transporter 8 (ZnT8) positivity were also shown as the markers of faster progression (P<0.0001 for both). The proportion of LADA patients requiring insulin was significantly higher in the group of subjects treated also with sulfonylurea in the first year from diagnosis compared with those treated with diet and/or insulin sensitizers (P<0.001). The multivariate analysis confirmed that the presence of high GADA titer was a significant predictor of insulin requirement (P<0.0001, OR=6.95).ConclusionsHigh GADA titer, BMI ≤ 25, ZnT8 and IA-2ICpositivity and sulfonylurea treatment, in the first year from diagnosis, significantly increase the progression toward insulin requirement in LADA patients.
Optimization of the Cutting Process of Wood-Based Agglomerated Materials by Abrasive Water-Jet
Authors: Kvietková Monika , Barcík Štefan , Gašparík Miroslav 
Published: September 2014

Abstract
This paper deals with the cutting MDF, OSB, and plywood boards by abrasive water-jet (GMA Garnet Australian, grain size 80, MESH = 0.188 mm), with a kerf width depending on the material properties and technical parameters (material thickness, cutting direction, abrasive flow, and feed speed). The entry of water-jet cutting in the longitudinal direction produces changes in the material due to lateral leads spreading the width of the cut joints by an average of 0.20 mm for MDF boards, 0.3 mm for OSB boards, and 0.17 mm for plywood. On the exit side of the material, the water has the opposite effect. In relation to the thicknesses of the material, the width of the cut joints increases. The experiment has shown that the optimum value of the feed speed is explicitly 400 mm.min-1, at which the kerf width reaches the lowest dimensions both at entry and exit, and the abrasive flow of 450 g.min-1 has been shown as optimum.
Forest Litter Interception Model for a Sessile Oak Forest
Authors: Zagyvainé Kiss Katalin Anita , Kalicz Péter , Csáfordi Péter , Gribovszki Zoltán 
Published: September 2014

Abstract
Models that describe hydrological processes in forests may help to estimate the consequences of forestry interventions or of climate change. The authors employed a hydrologic model for estimation of forest litter interception of a middle-aged sessile oak (Quercus petraea) stand. Antecedent water content and the storage capacity of the forest litter were the main parameters of the model. The antecedent water content of the litter was estimated by the daily precipitation and temperature data, collected in Hidegviz Valley research catchment in a three year measurement period (2006-2008). The measurements were done by an instrument we developed ourselves, where the undisturbed forest litter samples were enclosed in frames and measured in daily time steps.
Method for preventing air pollution: Methane oxidation by two types of catalysts
Authors: Covaliu Cristina Ileana , Traistaru Gina Alina , Paraschiv Gigel 
Published: September 2014

Abstract
Methane oxidation using different catalysts is an useful process for preventing air pollution. This study presents the methane oxidation by two types of catalysts: Pd-Sn/Al2O3 and spinel mixed oxide, CuFe2O4. The Pd-Sn/Al2O3 was successfully prepared by sol-gel method and CuFe2O4 by co-precipitation method. The catalysts obtained have been characterized structurally, morphologically and texturally by X-ray diffraction (XRD), scanning electron microscopy (SEM) and specific surface area (BET). The catalytic activity tests regarding methane oxidation were also performed.
Study of phenolic compounds in red grapes and wines from Murfatlar wine center
Authors: Artem Victoria , Geana Elisabeta-Irina , Antoce Arina Oana 
Published: September 2014

Abstract
The latest research revealed that phenolic compounds play an important role in the quality of red wine, particularly on colour and astringency and also are responsible for the sanogenic or multiple benefic effects on human health after a moderate consumption of wine. This paper presents the ripening evolution of routine quality control parameters (sugars, acids, weight of 100 berries) and phenolic compounds (anthocyanins and polyphenolic index) during 2013 year for the most representative red grape varieties (Cabernet Sauvignon, Merlot, Feteasca Neagra, Pinot Noir and Mamaia) authorized to obtain wines with denomination of origin controlled in Murfatlar wine center. Also, the phenolic profile of obtained red wines was evaluated by reversedphase high performance liquid chromatography. The reported results were useful to find the optimum moment for grape harvest ensuring the production of high quality wines.
Evaluation of toxic metal levels in edible tissues of three wild captured freshwater fishes
Authors: Peycheva Katya , Makedonski Lubomir , Merdzhanova Albena , Stancheva Mona 
Published: September 2014

Abstract
River ecosystems are vulnerable to heavy metal pollution. Fish samples are considered as one of the most indicative factors, in fresh water systems, for the estimation of trace metals pollution potential since they are the final chain of aquatic web. The objective of the present study is to evaluate the concentration of some toxic elements (As, Hg, Pb, Cd and Ni) in edible part of three wild fresh water fish species (zander (Sander lucioperca), wels catfish (Silurus glanis) and European carp (Cyprinus Carpio)) caught from Bulgarian part of Danube river collected during 2010. The Danube River is the European Union's longest and the continent's second longest river that passes through or touches the borders of ten countries. It has a great importance in regard to biodiversity, economics and transportation. The elements (As, Pb, Cd and Ni) were assayed using Perkin Elmer Zeeman 3030 electrothermal atomic absorption spectrometer with an HGA-600 atomizer. Determination of Hg was performed using Milestone Direct Mercury Analyzer DMA-80. The results were expressed as μg/g dry weight. The order of heavy metal accumulation in the edible part of zander is As>Hg>Pb> Ni> Cd while the other two fish species show a different metal accumulation Hg > As >Pb> Ni > Cd. In all heavy metals, the accumulation of mercuric and arsenic proportion was significantly high in all three fish types.
Biological Control Against the Cowpea Weevil (Callosobruchus Chinensis L., Coleoptera: Bruchidae) Using Essential Oils of Some Medicinal Plants
Authors: Fatiha Righi Assia , Kada Righi , Khelil Anouar , Pujade-Villar Juli 
Published: September 2014

Abstract
Chickpea (Cicer arietinum L.) is a valuable foodstuff but unfortunately this legume is prone to insect attacks from the chick pea weevil (Callosobruchus chinensis L.). This serious pest damages the chickpea and causes decreases in the yield and in the nutritional quality. Biological control is being used to deal with this problem. We tried different doses of the essential oils of three new medicinal plants, namely Salvia verbenaca L., Scilla maritima L., and Artemisia herba-alba Asso to limit the damage of the chick pea weevil pest, and to protect consumer’s health. To determine the effect and efficiency of the oil, the tests were conducted using the different biological parameters of fertility, longevity, and fecundity, under controlled temperature and relative humidity (28°C and 75%). The effectiveness of organic oils was demonstrated. We tested these oils on the germination of seeds. The obtained results showed that the tested plant oils have a real organic insecticide effect. The essential oil of Artemisia proved most effective as a biocide; achieving a mortality rate of 100%. A significant reduction in longevity was observed under the effect of 30 μl of S. maritima (1.3 days) and S. verbenaca (2.8, 4.6 days), respectively, for males and females compared to 8 and 15 days for the control. For fecundity, an inhibition of oviposition was obtained using 30 μl of Salvia and Scilla essential oils. The test on the seed germination using different essential oils, showed no damage to the germinating seeds. The germination rate was 99%. These findings suggest that the tested plants can be used as a bioinsecticide for control of the C. chinensis pest of stored products.
The Effect of Potato Ridge Height and Harvest Date on Tuber Injuries
Authors: Rymuza Katarzyna , Bombik Antoni , Stopa Dariusz , Pawlonka Zbigniew 
Published: September 2014

Abstract
A potato experiment was conducted from 2004 to 2006 at the Zawady Experimental Farm. The farm is part of the University of Natural Sciences and Humanities in Siedlce, Poland. Tuber infection and injury by diseases and pathogens of three potato cultivars were assessed according to the potato ridge height and harvest date. The weight of mechanically injured tubers was also determined depending on the potato ridge height and harvest date. The weight of potato tubers infected by fungal and bacterial diseases was influenced by the cultivar, growing season, harvest date, and ridge height. Potatoes grown to their standard height and height ridges, were significantly less infected by diseases at the first harvest date. The weight of tubers in which the tubers were injured by soil pests, was affected by the cultivar and ridge height. Potatoes cultivated in a ridge which was 20 cm high, had tubers with significantly less mechanical injuries compared with a low (16 cm) ridge and high (24 cm) ridge.
Some Brain Peptides Regulating the Secretion of Digestive Enzymes in the Indian Meal Moth, Plodia Interpunctella (Lepidoptera: Pyralidae)
Authors: Sajjadian Seyede Minoo , Hosseininaveh Vahid , Jahromi Khalil Talebi 
Published: September 2014

Abstract
The Indian meal moth, Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae) is a destructive polyphagous pest of many stored products. To interfere with the physiological processes, especially digestion, of the larval pest, more information on the regulatory mechanisms is needed. The brain extract from 1-day-old last instar larvae of P. interpunctella was examined. In the bioassays, the midguts were treated with the brain extract, and the carbohydrase and protease activities were measured. The brain extract showed increasing dose-dependent effects on α-amylase, α-glucosidase, β-glucosidase, α-galactosidase, β-galactosidase, and trypsin secretion in the larval midgut. The extract was further characterised and partially purified using high performance liquid chromatography (HPLC). Several peptides were determined in the brain extract regulating hydrolase activities in the larval midgut of the pest.
Environmental Issues in the Media – Studentsí Perceptions in the Three Nordic-Baltic Countries
Authors: Keinonen Tuula , Yli-Panula Yli-Panula , Svens Maria , Vilkonis Rytis , Persson Christel , Palmberg Irmeli 
Published: September 2014

Abstract
The media, as a source of information, is supposed to have a significant role in effecting peopleís environmental knowledge and attitudes. The purpose of this study was to find studentsí perceptions of environmental issues as presented in the media and how students in Finland, Lithuania and Sweden used these media sources in the matters related to environmental issues. The most important source of environmental knowledge was found to be the Internet, followed by newspapers, television, school and education. In their own lives, students discussed environmental issues every day and, to some extent, in social media, discussion forums and blogs. In Finland, newspapers represented the most important source of environmental knowledge; in Lithuania, environmental organisations were the most prevalent, and, in Sweden, it was in a school or educational context. Based on these results, it was concluded that, in order to reach both genders of students in different countries and to more greatly benefit from all sources of information, a variety of media should be used in education for sustainability.
Sigara (Halicorixa) Mayri (Fieber, 1860) (Hemiptera: Heteroptera: Corixidae), A New Species for Ukraine
Authors: Grandova Maria A. 
Published: September 2014

Abstract
Sigara (Halicorixa) mayri is a Ponto-East Mediterranean species but it has not been recorded previously in Ukraine. This study shows that S. mayri lives in most of southern Ukraine. Within this territory it can be classified as a rare species distributed mostly along the sea coast.
Clinical value of whole-body magnetic resonance imaging in health screening of general adult population
Authors: Tarnoki David Laszlo , Tarnoki Adam Domonkos , Richter Antje , Karlinger Kinga , Berczi Viktor , Pickuth Dirk 
Published: September 2014

Abstract
Background. Whole-body magnetic resonance imaging (WB-MRI) and angiography (WB-MRA) has become increasingly popular in population-based research. We evaluated retrospectively the frequency of potentially relevant incidental findings throughout the body.
Materials and methods. 22 highly health-conscious managers (18 men, mean age 47±9 years) underwent WBMRI and WB-MRA between March 2012 and September 2013 on a Discovery MR750w wide bore 3 Tesla device (GE Healthcare) using T1 weighted, short tau inversion recovery (STIR) and diffusion weighted imaging (DWI) acquisitions according to a standardized protocol.
Results. A suspicious (pararectal) malignancy was detected in one patient which was confirmed by an endorectal sonography. Incidental findings were described in 20 subjects, including hydrocele (11 patients), benign bony lesion (7 patients) and non-specific lymph nodes (5 patients). Further investigations were recommended in 68% (ultrasound: 36%, computed tomography: 28%, mammography: 9%, additional MRI: 9%). WB-MRA were negative in 16 subjects. Vascular normal variations were reported in 23%, and a 40% left proximal common carotid artery stenosis were described in one subject.
Conclusions. WB-MRI and MRA lead to the detection of clinically relevant diseases and unexpected findings in a cohort of healthy adults that require further imaging or surveillance in 68%. WB-MR imaging may play a paramount role in health screening, especially in the future generation of (epi)genetic based screening of malignant and atherosclerotic disorders. Our study is the first which involved a highly selected patient group using a high field 3-T wide bore magnet system with T1, STIR, MRA and whole-body DWI acquisitions as well.
Effect of Transcutaneous Electrical Nerve Stimulation on Pain, Function, and Quality of Life in Fibromyalgia: A Double-Blind Randomized Clinical Trial
Authors: Noehren Brian , Dailey Dana L. , Rakel Barbara A. , Vance Carol G.T. , Zimmerman Miriam B. , Crofford Leslie J. , Sluka Kathleen A. 
Published: September 2014

BackgroundFibromyalgia is a common chronic pain condition that has a significant impact on quality of life and often leads to disability. To date, there have been few well-controlled trials assessing the utility of nonpharmacological treatment modalities such as transcutaneous electrical nerve stimulation (TENS) in the management of pain and improvement in function in individuals with fibromyalgia.ObjectivesThe purpose of this study will be to complete a long-term, multicenter study to assess the effects of TENS in women with fibromyalgia.DesignThis will be a phase II randomized, double-blind, placebo-controlled, multicenter clinical trial.ParticipantsThree hundred forty-three participants with fibromyalgia will be recruited for this study.InterventionParticipants will be randomly assigned to 1 of 3 groups: the intervention (TENS), placebo, or no treatment. After completing the randomized period, all participants will receive the intervention for 1 month. The participants will be asked to use TENS at the highest tolerable level for at least 2 hours daily during physical activity.MeasurementsThe primary outcome will be pain with movement, with secondary outcomes assessing functional abilities, patient-reported outcomes, and quantitative sensory testing.LimitationsBecause having participants refrain from their typical medications is not practical, their usage and any change in medication use will be recorded.ConclusionsThe results of this study will provide some of the first evidence from a large-scale, double-blind, placebo-controlled trial on the effectiveness of TENS on pain control and quality-of-life changes in patients with fibromyalgia.