bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cellular Antisense Activity of PNA–Oligo(bicycloguanidinium) Conjugates Forming Self‐Assembled Nanoaggregates
Authors: Valero Julián , Shiraishi Takehiko , de Mendoza Javier , Nielsen Peter E. 
Published: May 2015

AbstractA series of peptide nucleic acid–oligo(bicycloguanidinium) (PNA–BGn) conjugates were synthesized and characterized in terms of cellular antisense activity by using the pLuc750HeLa cell splice correction assay. PNA–BG4 conjugates exhibited low micromolar antisense activity, and their cellular activity required the presence of a hydrophobic silyl terminal protecting group on the oligo(BG) ligand and a minimum of four guanidinium units. Surprisingly, a nonlinear dose–response with an activity threshold around 3–4 μM, indicative of large cooperativity, was observed. Supported by light scattering and electron microscopy analyses, we propose that the activity, and thus cellular delivery, of these lipo‐PNA–BG4 conjugates is dependent on self‐assembled nanoaggregates. Finally, cellular activity was enhanced by the presence of serum. Therefore we conclude that the lipo‐BG‐PNA conjugates exhibit an unexpected mechanism for cell delivery and are of interest for further in vivo studies.
A Versatile Strategy for the Semisynthetic Production of Ser65 Phosphorylated Ubiquitin and Its Biochemical and Structural Characterisation
Authors: Han Cong , Pao Kuan‐Chuan , Kazlauskaite Agne , Muqit Miratul M. K. , Virdee Satpal 
Published: May 2015

AbstractUbiquitin phosphorylation is emerging as an important regulatory layer in the ubiquitin system. This is exemplified by the phosphorylation of ubiquitin on Ser65 by the Parkinson's disease‐associated kinase PINK1, which mediates the activation of the E3 ligase Parkin. Additional phosphorylation sites on ubiquitin might also have important cellular roles. Here we report a versatile strategy for preparing phosphorylated ubiquitin. We biochemically and structurally characterise semisynthetic phospho‐Ser65‐ubiquitin. Unexpectedly, we observed disulfide bond formation between ubiquitin molecules, and hence a novel crystal form. The method outlined provides a direct approach to study the combinatorial effects of phosphorylation on ubiquitin function. Our analysis also suggests that disulfide engineering of ubiquitin could be a useful strategy for obtaining alternative crystal forms of ubiquitin species thereby facilitating structural validation.
Minimizing acute kidney injury during TAVR: The Importance of Seeing the Trees and the Forest
Authors: Krishnaswamy Amar , Tuzcu E. Murat 
Published: May 2015

Key Points

The importance of minimizing radio‐contrast load among patients with CKD undergoing TF‐TAVR is highlighted by Arrigo and coworkers.
Use of non‐contrast annular sizing techniques such as cardiac MRI or 3D TEE should be encouraged for precise valve sizing.
Limited‐contrast CT performed with contrast infusion via a pigtail catheter placed in the descending aorta provides excellent iliofemoral assessment for TF‐TAVR.
Experience and accuracy can result in parity of outcomes following one or two stents for left main stem bifurcation disease
Authors: Colombo Antonio , Ruparelia Neil 
Published: May 2015

Key Points:

Approximately one‐third of patients presenting with significant distal left main stem disease, due to the complexity of disease, require the implantation of two‐stents to achieve acceptable revascularization.
In patients with complex distal unprotected left main stem bifurcation disease, a two‐stent strategy is associated with long‐term outcomes that are comparable to a single‐stent strategy in spite of the presence of higher plaque burden and greater lesion complexity.
Future studies should focus upon the impact of procedure optimization (e.g. with the routine use of intravascular imaging) and newer generation coronary stents upon long‐term outcomes in this challenging patient group.
The radialist's religious fervor
Authors: Heuser Richard R. 
Published: May 2015

Key Points

The MATRIX Trial proved that radial was superior to femoral in ACS patients due to reduction in complications with equal effectiveness.
This large study suggests that the radial approach can be equally successful compared to the femoral approach in CTOs.
Since so few radial CTO procedures were included, one wonders whether CTO operators with MATRIX‐like radial experience could have less complications than the femoral approach in these procedures.
Radial PCI and the obesity paradox: Insights from blue cross blue shield of michigan cardiovascular consortium (BMC2)
Authors: McDonagh Jonathan R. , Seth Milan , LaLonde Thomas A. , Khandewal Akshay K. , Wohns David H. , Dixon Simon R. , Gurm Hitinder S. 
Published: May 2015

ObjectiveTo examine if transradial approach (TRA) negates the increased risk associated with femoral access in lean and morbidly obese patients undergoing percutaneous coronary intervention (PCI).BackgroundPatients at extremes of body mass are at increased risk of bleeding after PCI. TRA has been associated with lower overall rates of bleeding compared to femoral approach.Methods and ResultsWe studied patients undergoing emergent and elective PCI from 2010 to 2012 across 47 hospitals in Michigan who participate in the Blue Cross Blue Shield of Michigan Cardiovascular Consortium PCI registry. The primary outcomes were the incidences of bleeding and postprocedure transfusion. Propensity matching (PM) was used to adjust for nonrandomized use of TRA. TRA was used in 10,235 procedures. In PM analyses, use of TRA was associated with a reduction in bleeding (0.80 vs. 1.9%, odds ratio [OR] = 0.41, 95% confidence interval [CI] = 0.32–0.54, P < 0.001) and need for transfusion (1.4 vs. 2.5%, OR = 0.56, 95% CI = 0.45–0.69, P < 0.001) compared with femoral access. The absolute difference in bleeding and transfusion associated with TRA was largest in patients with lean body mass (BMI < 25 kg/m2) and morbid obesity (BMI ≥ 40 kg/m2): Lean patients undergoing TRA had a rate of bleeding of 1.2 versus 2.8% for femoral access (OR = 0.43, 95% CI = 0.24–0.77, P = 0.002); and rate of transfusion of 2.4 versus 3.9% (OR = 0.61, 95% CI = 0.40–0.94, P = 0.019). The morbidly obese had a rate of bleeding of 0.8% for TRA versus 2.4% for femoral access (OR = 0.33, 95% CI = 0.44–0.72, P = 0.004); and rate of transfusion of 1.7 versus 3.0%, (OR = 0.55, 95% CI = 0.30–1.0, P = 0.051).ConclusionsCompared with the femoral approach, TRA is associated with a reduction in bleeding across all patients undergoing PCI and the absolute benefit was greatest in those with extremely low or high BMI. © 2015 Wiley Periodicals, Inc.
Bivalirudin is associated with improved clinical and economic outcomes in heart failure patients undergoing percutaneous coronary intervention: Results from an observational database
Authors: Pinto Duane S. , Kohli Payal , Fan Weihong , Kirtane Ajay J. , Kociol Robert D. , Meduri Christopher , Deliargyris Efthymios N. , Prats Jayne , Reynolds Matthew R. , Stone Gregg W. , Michael Gibson C. 
Published: May 2015

BackgroundOutcomes with bivalirudin compare favorably with heparin ± GPIIb/IIIa receptor inhibition (heparin ± GPI) during percutaneous coronary intervention (PCI). Patients with congestive heart failure (CHF) have increased risk for complications. The objective was to investigate clinical and economic outcomes for bivalirudin ± GPI vs. heparin ± GPI among PCI patients with CHF.MethodsUsing the Premier Hospital Database, PCI patients with CHF were stratified by anticoagulant: bivalirudin, bivalirudin ± GPI, heparin and heparin ± GPI. The probability of receiving bivalirudin ± GPI was estimated using individual and hospital variables. Using propensity scores, each bivalirudin ± GPI patient was matched to a heparin ± GPI patient. The primary outcome was in‐hospital death. Bleeding rates, transfusion, length of stay and in‐hospital cost were ascertained.ResultsOverall, 116,313 patients at 315 hospitals received bivalirudin (n = 45,559) bivalirudin + GPI (n = 8,115), heparin (n = 27,972) or heparin + GPI (n = 34,667). Patients had STEMI (21.2%), NSTEMI (29.1%), unstable angina (16.6%), stable angina (5.7%) or other ischemic heart disease (24.2%). Of these, 79.1% of bivalirudin patients matched, resulting in 84,948 analyzed patients. Compared with heparin ± GPI patients, bivalirudin ± GPI patients had fewer deaths (3.3% vs. 3.9%; p < 0.0001), less clinically apparent bleeding (10.2% vs. 11.4%; p < 0.0001), clinically apparent bleeding with transfusion (2.7% vs. 3.2%, p <0.0001), and transfusion (8.5% vs. 9.8%, p < 0.0001). Patients receiving bivalirudin had shorter length of stay (6.3 vs. 6.8 days; p < 0.0001) and lower in‐hospital cost (mean $26,706 vs. $27,166 [median $19,414 vs. $19,798]; p < 0.0001). In conclusion, this is the largest retrospective analysis of PCI patients with CHF and demonstrates bivalirudin ± GPI compared with heparin ± GPI is associated with lower inpatient rates of death, bleeding, and cost. © 2015 Wiley Periodicals, Inc.
ChemInform Abstract: Dielectric Properties, Polymorphism, Structural Characterisation and Phase Diagram of Na2Nb4O11—Ag2Nb4 O11 Solid Solutions.
Authors: Maso Nahum , West Anthony R. 
Published: May 2015

Abstract(Na1‐xAgx)2Nb4O11 solid solution is prepared by solid state reaction of NaNO3, Ag2O, and Nb2O5 (650 °C, 2 d).
ChemInform Abstract: Hydrothermal Synthesis of a New Bi‐based (Ba0.82K0.18) (Bi0.53Pb0.47)O3 Superconductor.
Authors: Kumada Nobuhiro , et al.  
Published: May 2015

AbstractThe title compound is hydrothermally synthesized from an aqueous mixture of PbBi2O5.9 (obtained by stirring a solution of NaBiO3 and Pb(NO3)2 at 10 °C for 5 d), Ba(OH)2, and KOH (autoclave, 240 °C, 2 d).
ChemInform Abstract: Metal‐Free Efficient Photocatalyst for Stable Visible Water Splitting via a Two‐Electron Pathway.
Authors: Liu Juan , Liu Yang , Liu Naiyun , Han Yuzhi , Zhang Xing , Huang Hui , Lifshitz Yeshayahu , Lee Shuit‐Tong , Zhong Jun , Kang Zhenhui 
Published: May 2015

AbstractNanocomposites of carbon nanodots embedded in a C3N4 matrix are prepared by heating a mixture of ammonia‐treated carbon nanodots and urea powder at 550 °C for 3 h in an alumina crucible.
ChemInform Abstract: Rare‐Earth Manganese Arsenides RE4Mn2As5 (RE: La—Pr).
Authors: Tabassum Danisa , Lin Xinsong , Mar Arthur 
Published: May 2015

AbstractThe title compounds are prepared from the elements in the presence of Ga flux (fused silica tubes, 800 °C for 3 d, 1050 °C for 2 d) and characterized by powder and single crystal XRD.
ChemInform Abstract: Hydroflux Synthesis and Crystal Structure of New Lanthanide Tungstate Oxyhydroxides.
Authors: Latshaw Allison M. , Smith Mark D. , Chance W. Michael , zur Loye Hans‐Conrad 
Published: May 2015

AbstractSingle crystals of new tungsten‐containing Na5Ln(OH)6WO4 (Ln: Er, Tm, Yb) are prepared by the hydroflux method from Na2SiO3, Ln2O3, WO3, NaOH, and H2O (autoclave, 230 °C, 12 h).
ChemInform Abstract: Direct Reductive Coupling of Secondary Amides: Chemoselective Formation of Vicinal Diamines and Vicinal Amino Alcohols.
Authors: Huang Pei‐Qiang , Lang Qi‐Wei , Wang Ai‐E , Zheng Jian‐Feng 
Published: May 2015

AbstractThe first one‐pot reductive homocoupling reaction of secondary amides and cross‐coupling reaction of secondary amides with ketones to give secondary vicinal diamines and amino alcohols are reported.
ChemInform Abstract: Rhodium(I)‐Catalyzed Intermolecular [2 + 2 + 2] Cycloaddition of Allenyl Aldehydes with Alkynes and Related Cyclization.
Authors: Oonishi Yoshihiro , Saito Akira , Sato Yoshihiro 
Published: May 2015

AbstractInternal alkynes (II) and (IV) undergo regio‐ and enantioselective [2 + 2 + 2] cycloadditions with allenyl aldehydes to form dihydropyran derivatives.
ChemInform Abstract: Hydrofluorination of Alkynes Catalyzed by Gold Bifluorides.
Authors: Nahra Fady , Patrick Scott R. , Bello Davide , Brill Marcel , Obled Alan , Cordes David B. , Slawin Alexandra M. Z. , O'Hagan David , Nolan Steven P. 
Published: May 2015

AbstractNine new N‐heterocyclic carbene gold bifluoride complexes are synthesized which are found to be efficient catalysts for the hydrofluorination of symmetrical and unsymmetrical alkynes.
ChemInform Abstract: N‐Aminopyridinium Salts as Precursors for N‐Centered Radicals — Direct Amidation of Arenes and Heteroarenes.
Authors: Greulich Tobias W. , Daniliuc Constantin G. , Studer Armido 
Published: May 2015

AbstractBy means of photoredox catalysis under mild conditions arenes and hetarenes are amidated.
ChemInform Abstract: Fe(HSO4)3: An Efficient, Heterogeneous and Reusable Catalyst for C‐Alkylation of β‐Dicarbonyl Compounds.
Authors: Khafajeh Samaneh , Akhlaghinia Batool , Rezazadeh Soodabeh , Eshghi Hossein 
Published: May 2015

AbstractFe(HSO4)3 is used as an efficient catalyst for the heterogeneous addition of a series of benzylic and allylic alcohols to various β‐dicarbonyl compounds, which affords good yields of C‐alkylated products.
ChemInform Abstract: An Iron and Copper System Catalyzed C—H Arylation of Azoles with Arylboronic Acids.
Authors: Hu Wei‐Ye , Wang Pei‐Pei , Zhang Song‐Lin 
Published: May 2015

AbstractAn inexpensive and effective iron/copper catalytic system is used in the cross‐coupling of benzoxazoles and benzothiazoles with arylboronic acids.
ChemInform Abstract: Trifluoromethylation and Pentafluoroethylation of Vinylic Halides with Low‐Cost RfH‐Derived CuRf (Rf = CF3, C2F5).
Authors: Lishchynskyi Anton , Mazloomi Zahra , Grushin Vladimir V. 
Published: May 2015

AbstractMono‐, di‐ and trisubstituted vinyl bromides and vinyl iodides endowed with various functional groups undergo trifluoromethylation and pentafluoroethylation in generally high yield while retaining the stereochemistry of the substrate.
ChemInform Abstract: Platinum‐Catalyzed Allylation of Carbon Electrophiles with Alkenylsilanes.
Authors: Kinoshita Hidenori , Kizu Ryosuke , Inoue Gen , Fujimoto Masayuki , Saito Masanori , Ichikawa Junji , Hosomi Akira , Miura Katsukiyo 
Published: May 2015

AbstractZ‐Alkenylsilanes are used as γ‐substituted allylsilane precursors for the allylation of carbon electrophiles such as aryl and alkyl acetals and aminals which may be synthesized in situ from the corresponding aldehyde and ortho‐formate or methyl carbamate, respectively.
ChemInform Abstract: Oxidative Umpolung α‐Alkylation of Ketones.
Authors: Shneider O. Svetlana , Pisarevsky Evgeni , Fristrup Peter , Szpilman Alex M. 
Published: May 2015

AbstractA variety of 1,3‐dicarbonyl compounds and the lithium enolates of simple ketones are submitted to a hypervalent iodine‐mediated Umpolung‐reaction using dialkyl zinc as the alkylating agent.
ChemInform Abstract: Regioselective Synthesis of 1,3‐ and 1,2‐Tocopheryl Glyceride Ethers of Carboxylic Acids.
Authors: Choi Bo Seul , Choi Jeongae , Bak Seonyoung , Koo Sangho 
Published: May 2015

AbstractSelective deprotection of 1,2‐tocopheryl glyceride ethers (V) succeeds with Super‐Hydride, but the method suffers from a certain degree of acyl group migration even at low temperature and extremely short reaction time (formic acid quenching).
ChemInform Abstract: Base‐Promoted Oxidative C—H Functionalization of α‐Amino Carbonyl Compounds under Mild Metal‐Free Conditions: Using Molecular Oxygen as the Oxidant.
Authors: Li Lei , Zhao Yu‐Long , Wang Qian , Lin Tao , Liu Qun 
Published: May 2015

AbstractThe reaction provides access to a variety of di‐, tri‐ and tetrasubstituted α‐aminocyclopentenones by an air‐mediated [4 + 1]‐carbocyclization reaction of N‐aryl α′‐amino‐α,β‐unsaturated ketones with ethyl cyanoacetate, isocyanoacetate or nitroalkanes.
ChemInform Abstract: Catalytic syn‐Selective Direct Aldol Reactions of Benzophenone Glycine Imine with Aromatic, Heteroaromatic and Aliphatic Aldehydes.
Authors: Lou Sha , Ramirez Antonio , Conlon David A. 
Published: May 2015

AbstractN‐(Diphenylmethylene)glycinates undergo a highly stereoselective silver‐catalyzed aldol reaction affording ester in high yields.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Radical Reactions for Highly Enantioselective β‐Hydroxylation of Enals.
Authors: Zhang Yuexia , Du Yu , Huang Zhijian , Xu Jianfeng , Wu Xingxing , Wang Yuhuang , Wang Ming , Yang Song , Webster Richard D. , Chi Yonggui Robin 
Published: May 2015

AbstractThis method allows the synthesis of β‐hydroxyesters from simple enals with excellent enantioselectivities and in good yields.
ChemInform Abstract: A Facile and Mild Approach for Stereoselective Synthesis of α‐Fluoro‐.alpha±beta.‐unsaturated Esters from α‐Fluoro‐β‐keto Esters via Deacylation.
Authors: Qian Jinlong , Yi Wenbin , Lv Meifang , Cai Chun 
Published: May 2015

AbstractThe efficient method is scalable and delivers the products with high yields and excellent Z‐stereoselectivity.
ChemInform Abstract: Palladium‐Catalyzed ortho‐Sulfonylation of 2‐Aryloxypyridines and Subsequent Formation of ortho‐Sulfonylated Phenols.
Authors: Xu Yinfeng , Liu Ping , Li Shun‐Li , Sun Peipei 
Published: May 2015

AbstractBoth electron‐rich and electron‐deficient substrates can be used and various functional groups are tolerated.
ChemInform Abstract: Copper(II)‐Promoted C—C Bond Formation by Oxidative Coupling of Two C(sp3)‐H Bonds Adjacent to Carbonyl Group to Construct 1,4‐Diketones and Tetrasubstituted Furans.
Authors: Mao Shuai , Gao Ya‐Ru , Zhang Shao‐Liang , Guo Dong‐Dong , Wang Yong‐Qiang 
Published: May 2015

AbstractOptimized conditions are developed for the preparation of the diketones (important substructures of natural products and pharmaceuticals) and for the simple, efficient, and regioselective formation of polysubstituted furans.
ChemInform Abstract: Highly Enantioselective Michael Reaction Employing Cycloheptanone and Cyclooctanone as Nucleophiles.
Authors: Xia Ai‐Bao , Zhao Long , Wang Tao , Zhang Yan‐Peng , Zhong Ai‐Guo , Xu Dan‐Qian , Xu Zhen‐Yuan 
Published: May 2015

AbstractMichael adducts [(III) and (V)] are synthesized in good yields and high enantioselectivities using a hydroquinine‐based primary amine as catalyst.
ChemInform Abstract: Asymmetric Synthesis of Trisubstituted Aziridines via Aza‐Darzens Reaction of Chiral Sulfinimines.
Authors: Moragas Toni , Churcher Ian , Lewis William , Stockman Robert A. 
Published: May 2015

AbstractThe method provides a rapid access to 2,2′,3‐substituted aziridines.
ChemInform Abstract: Atom‐Economic Generation of Gold Carbenes: Gold‐Catalyzed Formal [3 + 2] Cycloaddition Between Ynamides and Isoxazoles.
Authors: Zhou Ai‐Hua , He Qiao , Shu Chao , Yu Yong‐Fei , Liu Shuang , Zhao Tian , Zhang Wei , Lu Xin , Ye Long‐Wu 
Published: May 2015

AbstractFormal [3 + 2] cycloaddition of various ynamides with isoxazoles results in the formation of a series of 2‐aminopyrroles.
ChemInform Abstract: Gold(I)‐Catalyzed Diazo Cross‐Coupling: A Selective and Ligand‐Controlled Denitrogenation/Cyclization Cascade.
Authors: Xu Guangyang , Zhu Chenghao , Gu Weijin , Li Jian , Sun Jiangtao 
Published: May 2015

AbstractAn unprecedented gold‐catalyzed ligand‐controlled cross‐coupling of diazo compounds by sequential selective denitrogenation and cyclization affords N‐substituted pyrazoles in a position‐switchable mode.
ChemInform Abstract: One‐Pot, Three Component Synthesis of Thiazol‐2(3H)‐imines Using Poly(4‐vinylpyridine) as an Efficient Reusable Heterogeneous Basic Catalyst.
Authors: Yahyazadeh Asieh , Abbasi Shiran Jafar , M. Yamin Bohari , Shirini Farhad , Mamaghani Manouchehr 
Published: May 2015

AbstractThe regioselective and green method produces the products in excellent yields.
ChemInform Abstract: Formal Palladium‐Catalyzed Asymmetric Hydrogenolysis of Racemic N‐Sulfonyloxaziridines.
Authors: Song Bo , Yu Chang‐Bin , Huang Wen‐Xue , Chen Mu‐Wang , Zhou Yong‐Gui 
Published: May 2015

AbstractThe method provides a high‐yielding access to chiral aryl and alkyl substituted sultams and benzosultams with excellent enantiomeric excess.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Cyclocondensation of 2‐Aryl Carboxylic Acids and Enones: Highly Enantioselective Synthesis of δ‐Lactones.
Authors: Cheng Jin‐Tang , Chen Xiang‐Yu , Ye Song 
Published: May 2015

AbstractDepending on the substrates′ substituents the products are obtained with moderate to good yields and with no to excellent diastereoselectivity.
ChemInform Abstract: Rapid Synthesis of 4‐Arylchromenes from ortho‐Substituted Alkynols: A Versatile Access to Restricted Isocombretastatin A‐4 Analogues as Antitumor Agents.
Authors: Renko Dolor , Provot Olivier , Rasolofonjatovo Evelia , Bignon Jerome , Rodrigo Jordi , Dubois Joelle , Brion Jean‐Daniel , Hamze Abdallah , Alami Mouad 
Published: May 2015

AbstractA high yield procedure for the synthesis of various functionalized 4‐arylchromene derivatives [cf.
ChemInform Abstract: Efficient and Convenient Copper‐Free Pd(OAc)2/Ruphos‐Catalyzed Sonogashira Coupling in the Preparation of Corfin Analogues.
Authors: Dasaradhan Changalaraya , Kumar Yadavalli Suneel , Prabakaran Kamalakannan , Khan Fazlur‐Rahman Nawaz , Jeong Euh Duck , Chung Eun Hyuk 
Published: May 2015

AbstractNovel 3‐(alkynyl)‐1H‐isochromen‐1‐ones (III) are obtained via a new Pd‐catalyzed Sonogashira coupling methodology.
ChemInform Abstract: An Atom‐Economic Green Approach: Oxidative Synthesis of Functionalized 1,4‐Dihydropyridines from N,N‐Dimethylenaminones and Amines.
Authors: Yu Fu‐Chao , Zhou Bei , Xu Hui , Chang Kwen‐Jen , Shen Yuehai 
Published: May 2015

AbstractThe oxidative three‐component reaction between N,N‐dimethylenaminones and amines features an unusual oxidation of in situ formed dimethyl amine to provide the 4‐methylene bridge of the dihydropyridines formed.
ChemInform Abstract: Copper‐Catalyzed Enantioselective Intramolecular Aryl C—N Coupling: Synthesis of Enantioenriched 2‐Oxo‐1,2,3,4‐tetrahydroquinoline‐3‐carboxamides via an Asymmetric Desymmetrization Strategy.
Authors: He Nian , Huo Yanping , Liu Jianguang , Huang Yusha , Zhang Shasha , Cai Qian 
Published: May 2015

AbstractThe products are obtained in good yields and with moderate enantiomeric excess.
ChemInform Abstract: Directed Metalation of 1‐Ester‐Substituted Indolizines: Base/Electrophile‐Controlled Regioselective Functionalization.
Authors: Amaral Monica F. Z. J. , Baumgartner Amanda A. , Vessecchi Ricardo , Clososki Giuliano C. 
Published: May 2015

Abstract1‐Ester‐substituted indolizines are metallated and then functionalized by trapping with various electrophiles including iodine, dimethylformamide, aldehydes or trimethylsilyl chloride, or by Negishi cross‐coupling partners.
ChemInform Abstract: C—H Bond Functionalization via [1,5]‐Hydride Shift/Cyclization Sequence: Approach to Spiroindolenines.
Authors: Wang Peng‐Fei , Jiang Chun‐Huan , Wen Xiaoan , Xu Qing‐Long , Sun Hongbin 
Published: May 2015

AbstractOptimized conditions A) can be applied to various indoles and benzaldehydes bearing a pyrrolidine moiety in o‐position.
ChemInform Abstract: Ga(OTf)3 Catalyzed Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones.
Authors: Xia Jingjing , Zhang Kehua 
Published: May 2015

Abstract2‐oxopyrimidinones, 2‐thiopyrimidinones and cyclopentapyrimidinones are prepared by Biginelli reaction in high yields in short reaction times.
ChemInform Abstract: One‐Pot Synthesis of [1,2,3]Triazolo[1,5‐a]pyrazine Derivatives from Ynones and Amino Azide.
Authors: Koguchi Shinichi , Sakurai Azusa , Niwa Kosuke 
Published: May 2015

AbstractThe title compounds are synthesized by regioselective one‐pot synthesis in three steps: cycloaddition, dehydration, and deprotection.
ChemInform Abstract: Highly Enantioselective Access to Diketopiperazines via Cinchona Alkaloid Catalyzed Michael Additions.
Authors: Cabanillas Alejandro , Davies Christopher D. , Male Louise , Simpkins Nigel S. 
Published: May 2015

AbstractMichael addition reactions of triketopiperazine derivatives to enones catalyzed by a cinchona alkaloid‐derived catalyst are studied.
ChemInform Abstract: RhIII‐Catalyzed Redox‐Neutral C—H Activation of Pyrazolones: An Economical Approach for the Synthesis of N‐Substituted Indoles.
Authors: Fan Zhoulong , Song Shanshan , Li Wei , Geng Kaijun , Xu Youjun , Miao Ze‐Hong , Zhang Ao 
Published: May 2015

AbstractThe reaction tolerates 3‐, 4‐ and 3,4‐substitutions in the aromatic groups in the pyrazolones, but no 2‐substituted or heteroaromatic groups.