bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Two Coordination Polymer Photocatalysts and Significant Enhancement of Their Catalytic Photodegradation Activity by Doping with Co2+ Ions
Authors: Li Duan‐Xiu , Ren Zhi‐Gang , Young David J. , Lang Jian‐Ping 
Published: March 2015

AbstractThe coordination polymers (CPs) [Zn2(tipm)(1,3‐BDC)2] (1) and [Co2(tipm)(1,3‐BDC)2]·0.5CH3CN (2·0.5CH3CN) were synthesized by the reactions of Zn(NO3)2 or Co(NO3)2 with tetrakis[4‐(1‐imidazolyl)phenyl]methane (tipm) and benzene‐1,3‐dicarboxylic acid (1,3‐H2BDC) under solvothermal conditions. Compounds 1 and 2 are isostructural and possess complicated three‐dimensional frameworks with the Schläfli symbol (4·72)(62·73·12)(4·62·73). Cobalt ions were incorporated into the Zn‐based CP framework 1 during solvothermal crystallization to yield [Zn(2–2x)Co2x(tipm)(1,3‐BDC)2]·bH2O (x = 2.4 %, b = 0 for 1a, x = 23 %, b = 1 for 2a·H2O). Doped CPs 1a and 2a·H2O exhibited greater catalytic photodegradation of the dye rhodamine B (RhB) than the undoped complexes 1 and 2 and many literature examples.
Calixarene‐Mediated Liquid Membrane Transport of Choline Conjugates 2: Transport of Drug‐Choline Conjugates and Neurotransmitters
Authors: Adhikari Birendra Babu , Roshandel Sahar , Fujii Ayu , Schramm Michael P. 
Published: March 2015

AbstractLower rim carboxylic acid calix[n]arenes and upper rim phosphonic acid functionalized calix[4]arenes effect selective transport of distinct molecular payloads through a liquid membrane. The secret to this success lies in the attachment of a receptor‐complementary handle. We find that the trimethylammonium ethylene group present in choline is a general handle for the transport of drug and drug‐like species. Furthermore, neurotransmitters possessing ionizable amine termini are also transported. Some limitations to this strategy have been uncovered as payloads become increasingly lipophilic. These developments reveal new approaches to synthetic receptor‐mediated selective small molecule transport in vesicular and cellular systems.
Base‐ and Radical‐Mediated Regio‐ and Stereoselective Additions of Thiols, Thio‐Sugars, and Thiol‐Containing Peptides to Trisubstituted Activated exo‐Glycals
Authors: Richard Mylène , Didierjean Claude , Chapleur Yves , Pellegrini‐Moïse Nadia 
Published: March 2015

AbstractA study was performed for the coupling of thiols, thio‐sugars, and thiol‐containing amino acids and peptides with trisubstituted activated anomeric sugar olefins under basic and radical conditions. The hydrothiolation reaction took place in a regio‐ and stereospecific manner and occurred at the anomeric center and mainly from an approach to the less crowded face, that is, opposite to the O‐4 protecting group. Furano‐ and pyranoglycosylidenes were valuable substrates for the base‐mediated coupling with aromatic and primary thiols, which included 6‐thio‐sugars, cysteine derivatives, and glutathione. The success of the radical‐mediated method depended on the thiol partners as well as the nature of the sugar olefins. Neither of the conditions required the protection of the sugar or the cysteine derivatives.
Electrochemical Biosensor Based on Nanocomposites Film of Thiol Graphene‐Thiol Chitosan/Nano Gold for the Detection of Carcinoembryonic Antigen
Authors: Li Guobao , Xue Qi , Feng Jijun , Sui Weiping 
Published: March 2015

AbstractIn this paper, a thiol graphene‐thiol chitosan‐gold nanoparticles (thGP‐thCTS‐AuNPs) nanocomposites film with porous structure was fabricated by electrochemically depositing on glassy carbon electrode (GCE), which exhibited good biocompatibility and improved conductivity, to construct immunosensor free label for detection of carcinoembryonic antigen (CEA). The electrochemical behavior of this immunosensor was investigated by cyclic voltammetry. Under the optimum conditions, the immunosensor revealed a good amperometric response to CEA in two linear ranges (0.3–8.0 ng mL−1 and 8.0–100 ng mL−1) with a detection limit of 0.03 ng mL−1. The results indicated that the immunosensor has the advantages of good selectivity, high sensitivity, and good stability for the determination of CEA.
A Comparative Study of 8‐Hydroxyquinoline and 8‐Hydroxyquinoline‐5‐sulfonic Acid for Antimony(III) Determination by AdSV. Substituent Effect on Sensitivity II
Authors: Rojas‐Romo Carlos , Arancibia Verónica 
Published: March 2015

AbstractA sensitive and selective method for the determination of Sb3+ based on the formation of its complexes with 8‐hydroxyquinoline (HQ) and 8‐hydroxyquinoline‐5‐sulfonic acid (HQS) is proposed. The best analytical conditions are: pH 5.4 and 2.2 for HQ and HQS, respectively; CHQ from 15.0 to 25.0 µmol L−1 and CHQS from 70.0 to 200.0 µmol L−1. The detection limits are 100.0 and 14.0 ng L−1 (tacc=30 s) for Sb3+ with HQ and HQS, respectively. The method using HQS as ligand has a 2.2‐fold higher sensitivity than that with HQ and the former was chosen for Sb3+ determination.
Physico‐chemical properties of instant ogbono (Irvingia gabonensis) mix powder
Authors: Bamidele Oluwaseun P. , Ojedokun Omotayo S. , Fasogbon Beatrice M. 
Published: March 2015

AbstractThe main objective of the research is to develop a recipe of instant dry soup mix for easy preparation of ogbono soup. Instant ogbono mix powder was processed using common locally ingredients. Dika kernel powder, dried ugwu leaf, crayfish, stock fish, and a mixture of locust bean, onion, seasoning and Cameroon powder were formulated at different ratios to find the best acceptable ogbono mix powder. The samples were subjected to proximate, functional, vitamin, mineral, and sensory analyses. The formulated sample D with the highest ratio of crayfish and stock fish had the highest value of protein and carbohydrate (24.13 and 35.61%, respectively). The control sample (100% dika kernel powder) was low in moisture content (6.20%) but high in crude fat, other samples followed in this order (control > A > B > C > D) for crude fat. Ash, crude fiber, and carbohydrate showed a significant difference (P < 0.05) in all the samples. The functional properties of the sample showed a significant difference (P < 0.05) in all the samples with the control having the highest value for the water absorption, swelling capacity, and bulk density which may be due to the high crude fiber and low moisture content recorded for the control sample in the proximate analysis. The mineral content of all the samples were higher than the control with phosphorous having the highest value and iron the least value. Vitamin C was the main dominating vitamin in the sample followed by vitamin B2, vitamin A, and vitamin B3. The sensory evaluation revealed that 100% dika kernel powder gave a good attribute of the soup but with less nutritional composition, while some formulated samples showed a similar attribute with higher nutritional value. Sample A with the highest overall acceptability had the best attribute of ogbono soup. Instant ogbono mix powder has higher nutritional value and easy to cook.
The Values of Crop Coefficients and Bowen Ratio of Field Crops in Areas with Insufficient Precipitation in Central Europe
Authors: Zábranský Petr , Pivec Jan , Brant Václav , Kroulík Milan , Škeříková Michaela 
Published: March 2015

AbstractThe aim of this study, based on measurements of actual evapotranspiration of vegetation, was to determine the values of the crop coefficient (Kc) for selected crops and the effect of growth on the dissipation of radiation energy. The actual evapotranspiration (ETa, mm day−1) ofBeta vulgaris,Hordeum vulgare,Medicago sativa,Sorghum bicolor,Triticum aestivumandZea mayswere measured under field conditions during 2007–2012 by the Bowen ratio energy balance (BREB) method. The values of potential evapotranspiration (ET0, mm day−1) and the dynamics of the above‐ground dry biomass production and values of the water productivity (WP, g H2O kg−1) were estimated. In the cereals, up to the onset of the ripening stage, the typical values ofβ(Bowen ratio) had exceeded 1.0. Crops such asM. sativa,B. vulgaris,S. bicolorandZ. mayshad contributed significantly more to the elimination of heating of the atmosphere than cereals. In the cereals (H. vulgareandT. aestivum) theKcvalues varied around 1.0 up to the onset of the ripening phase. Thereafter theKcvalues decreased to 0.5. Higher values of WP compared withH. vulgareandT. aestivumwere indicated byZ. maysandS. bicolorstands. Copyright © 2015 John Wiley & Sons, Ltd.
Base Excision Repair in the Mitochondria
Authors: Prakash Aishwarya , Doublié Sylvie 
Published: March 2015

ABSTRACTThe 16.5 kb human mitochondrial genome encodes for 13 polypeptides, 22 tRNAs and 2 rRNAs involved in oxidative phosphorylation. Mitochondrial DNA (mtDNA), unlike its nuclear counterpart, is not packaged into nucleosomes and is more prone to the adverse effects of reactive oxygen species (ROS) generated during oxidative phosphorylation. The past few decades have witnessed an increase in the number of proteins observed to translocate to the mitochondria for the purposes of mitochondrial genome maintenance. The mtDNA damage produced by ROS, if not properly repaired, leads to instability and can ultimately manifest in mitochondrial dysfunction and disease. The base excision repair (BER) pathway is employed for the removal and consequently the repair of deaminated, oxidized, and alkylated DNA bases. Specialized enzymes called DNA glycosylases, which locate and cleave the damaged base, catalyze the first step of this highly coordinated repair pathway. This review focuses on members of the four human BER DNA glycosylase superfamilies and their subcellular localization in the mitochondria and/or the nucleus, as well as summarizes their structural features, biochemical properties, and functional role in the excision of damaged bases. J. Cell. Biochem. 116: 1490–1499, 2015. © 2015 Wiley Periodicals, Inc.
Insights into inpatients with poor vision: A high value proposition
Authors: Press Valerie G. , Matthiesen Madeleine I. , Ranadive Alisha , Hariprasad Seenu M. , Meltzer David O. , Arora Vineet M. 
Published: March 2015

BACKGROUNDVision impairment is an under‐recognized risk factor for adverse events among hospitalized patients, yet vision is neither routinely tested nor documented for inpatients. Low‐cost ($8 and up) nonprescription “readers” may be a simple, high‐value intervention to improve inpatients' vision. We aimed to study initial feasibility and efficacy of screening and correcting inpatients' vision.METHODSFrom June 2012 through January 2014 we began testing whether participants' vision corrected with nonprescription lenses for eligible participants failing a vision screen (Snellen chart) performed by research assistants (RAs). Descriptive statistics and tests of comparison, including t tests and χ2 tests, were used when appropriate. All analyses were performed using Stata version 12 (StataCorp, College Station, TX).RESULTSOver 800 participants' vision was screened (n = 853). Older (≥65 years; 56%) participants were more likely to have insufficient vision than younger (<65 years; 28%; P < 0.001). Nonprescription readers corrected the majority of eligible participants' vision (82%, 95/116).DISCUSSIONAmong an easily identified subgroup of inpatients with poor vision, low‐cost readers successfully corrected most participants' vision. Hospitalists and other clinicians working in the inpatient setting can play an important role in identifying opportunities to provide high‐value care related to patients' vision. Journal of Hospital Medicine 2015;10:311–313. © 2015 Society of Hospital Medicine
MRI measurements of intracranial pressure in the upright posture: The effect of the hydrostatic pressure gradient
Authors: Alperin Noam , Lee Sang H. , Bagci Ahmet M. 
Published: March 2015

PurposeTo add the hydrostatic component of the cerebrospinal fluid (CSF) pressure to magnetic resonance imaging (MRI)‐derived intracranial pressure (ICP) measurements in the upright posture for derivation of pressure value in a central cranial location often used in invasive ICP measurements.Materials and MethodsAdditional analyses were performed using data previously collected from 10 healthy subjects scanned in supine and sitting positions with a 0.5T vertical gap MRI scanner (GE Medical). Pulsatile blood and CSF flows to and from the brain were quantified using cine phase‐contrast. Intracranial compliance and pressure were calculated using a previously described method. The vertical distance between the location of the CSF flow measurement and a central cranial location was measured manually in the mid‐sagittal T1‐weighted image obtained in the upright posture. The hydrostatic pressure gradient of a CSF column with similar height was then added to the MR‐ICP value.ResultsAfter adjustment for the hydrostatic component, the mean ICP value was reduced by 7.6 mmHg. Mean ICP referenced to the central cranial level was −3.4 ± 1.7 mmHg compared to the unadjusted value of +4.3 ± 1.8 mmHg.ConclusionIn the upright posture, the hydrostatic pressure component needs to be added to the MRI‐derived ICP values for compatibility with invasive ICP at a central cranial location. J. Magn. Reson. Imaging 2015;42:1158–1163.
Repeatedly foldable AMOLED display
Authors: Komatsu Ryu , Nakazato Ryo , Sasaki Takeru , Suzuki Akio , Senda Naoyuki , Kawata Takuya , Jimbo Yasuhiro , Aoyama Tomoya , Ohno Naoto , Kawashima Susumu , Ikeda Hisao , Eguchi Shingo , Hirakata Yoshiharu , Yamazaki Shunpei , Shiraishi Takashi , Yasumoto Seiji , Nakada Masataka , Sato Masataka , Bower Chris , Cotton Darryl , Matthews Andrew , Andrew Piers , Gheorghiu Catalin , Bergquist Johan 
Published: March 2015

AbstractIn this study, a 5.9‐inch foldable active‐matrix organic light emitting diode (AMOLED) display was developed. A folding test was performed repeatedly. The display survived the folding test (100,000 folds) with a curvature radius of 2 mm. To protect an organic light emitting diode (OLED) against moisture, inorganic passivation layers are provided on the upper and lower sides of the flexible display. Using our transfer technology, high density passivation layers can be obtained. The measured water vapor transmission rate of the layer is 7 × 10−6 g/m2⋅day or less, which improves OLED reliability. With these techniques, we have developed a book‐type display, which is repeatedly foldable like a book, and a tri‐fold display including a display area, which is foldable in three.
The outcome of surgical treatment for elderly patients with gastric carcinoma
Authors: Sakurai Katsunobu , Muguruma Kazuya , Nagahara Hisashi , Kimura Kenjiro , Toyokawa Takahiro , Amano Ryosuke , Kubo Naoshi , Tanaka Hiroaki , Ohtani Hiroshi , Yashiro Masakazu , Maeda Kiyoshi , Ohira Masaichi , Hirakawa Kosei 
Published: March 2015

BackgroundThe aim of this study was to clarify the operative mortality and long‐term survival of gastrectomy for elderly patients with gastric cancer.MethodsA total of 461 patients who underwent gastrectomy for gastric cancer in our hospital were classified as elderly group (≥80 years‐old, 95 patients) and control group (60–69 years‐old, 366 patients).ResultsThe frequency of comorbidities was significantly (P < 0.05) higher in elderly group (74.7%) than that in the control group (49.5%). No significant difference of the postoperative complication rate was found between the elderly group (23.2%) and the control group (23.2%). Adjuvant chemotherapy was 9.5% in the elderly group, which was significantly less than 29.0% of the control group (P < 0.05). Stage II and III elderly patients had worse disease specific survival (DSS) than controls did. In the elderly, overall survival (OS) was significantly worse than DSS in stage I patients (P < 0.05).ConclusionsThe operative complication rate of elderly patients was comparable to the control group. Comorbidity and occurrence of secondary malignant disease should be followed for elderly patients at stage I. For stage II and III disease patients, a novel drug which is acceptable for the elderly is needed as a postoperative therapy. J. Surg. Oncol. 2015 111:848–854. © 2015 The Authors. Journal of Surgical Oncology Published by Wiley Periodicals, Inc.
Luminescent Difluoroboron β‐Diketonate PEG‐PLA Oxygen Nanosensors for Tumor Imaging
Authors: Samonina‐Kosicka Jelena , Weitzel Douglas H. , Hofmann Christina L. , Hendargo Hansford , Hanna Gabi , Dewhirst Mark W. , Palmer Gregory M. , Fraser Cassandra L. 
Published: March 2015

Surface modification of nanoparticles and biosensors is a dynamic, expanding area of research for targeted delivery in vivo. For more efficient delivery, surfaces are PEGylated to impart stealth properties, long circulation, and enable enhanced permeability and retention (EPR) in tumor tissues. Previously, BF2dbm(I)PLA was proven to be a good oxygen nanosensor material for tumor hypoxia imaging in vivo, though particles were applied directly to the tumor and surrounding region. Further surface modification is needed for this dual‐emissive oxygen sensitive material for effective intravenous (IV) administration and passive and active delivery to tumors. In this paper, an efficient synthesis of a new dual‐emissive material BF2dbm(I)PLA‐mPEG is presented and in vitro stability studies are conducted. It is found that fabricated nanoparticles are stable for 24 weeks as a suspension, while after 25 weeks the nanoparticles swell and both dye and polymer degradation escalates. Preliminary studies show BF2dbm(I)PLA‐mPEG nanoparticle accumulation in a window chamber mammary tumor 24 h after IV injection into mice (C57Bl/6 strain) enabling tumor oxygen imaging.
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Inhibitory effect of dietary capsaicin on liver fibrosis in mice
Authors: Bitencourt Shanna , Stradiot Leslie , Verhulst Stefaan , Thoen Lien , Mannaerts Inge , van Grunsven Leo A. 
Published: March 2015

ScopeVirtually all chronic liver injuries result in the activation of hepatic stellate cells (HSCs). In their activated state, these cells are the main collagen‐producing cells implicated in liver fibrosis. Capsaicin (CPS), the active compound of chili peppers, can modulate the activation and migration of HSCs in vitro. Here, we evaluated the potential protective and prophylactic effects of CPS related to cholestatic and hepatotoxic‐induced liver fibrosis and its possible underlying mechanism of action.Methods and resultsMale Balb/c mice received dietary CPS after 3 days of bile duct ligation (BDL) or before and during carbon tetrachloride (CCl4) injections. Mice receiving dietary CPS after BDL had a significant improvement of liver fibrosis accompanied by a decrease in collagen deposition and downregulation of activation markers in isolated HSCs. In the CCl4 model, dietary CPS inhibited the upregulation of profibrogenic markers. However, CPS could not attenuate the CCl4‐induced fibrosis when it was already established. Furthermore, in vitro CPS treatment inhibited the autophagic process during HSC activation.ConclusionDietary CPS has potential benefits in the therapy of cholestatic liver fibrosis and in the prophylaxis of hepatotoxic‐induced liver injury.
A Case of Early Childhood Caries from Late Roman Ancaster, England
Authors: Bonsall L. , Ogden A. R. , Mays S. 
Published: March 2015

AbstractThis paper presents a differential diagnosis of pathological changes observed in the deciduous dentition of a child aged 3–4 years, recovered from a Late Roman (c. ad 270–410) cemetery at Ancaster, England. The entire maxillary dentition exhibited areas of missing enamel and erosion of the underlying dentine, which was most pronounced at the lingual surfaces of the anterior teeth, and lingual and occlusal surfaces of the molars. Additionally, the mandibular second molars and mandibular right first molar displayed superficial enamel erosion of the buccal surfaces. Radiography indicated normal enamel density, and no further dental pathology was identified. Conditions considered in a differential diagnosis included amelogenesis imperfecta, fluorosis, perimolysis, xerostomia‐related caries and early childhood caries (ECC). The nature and distribution of lesions implicates ECC – also known as ‘nursing caries’ or ‘baby‐bottle caries’ – as the most probable diagnosis. The potential significance of the findings for studies of infant health and feeding practices in past populations is discussed. Copyright © 2015 John Wiley & Sons, Ltd.
Nutrition labels influence value computation of food products in the ventromedial prefrontal cortex
Authors: Enax Laura , Hu Yang , Trautner Peter , Weber Bernd 
Published: March 2015

ObjectivePrevalence of obesity is high in most industrialized nations, and therefore, it is crucial to understand contextual factors underlying food choice. Nutrition labels are public policy interventions designed to adequately inform consumers about nutritional value and overall healthiness of food products. The present study examines how different nutrition labels, namely a purely information‐based label (guideline daily amount, GDA) and a more explicit traffic light (TL) label, influence product valuation and choice in a functional MRI setting.MethodsThirty‐five healthy participants across different BMIs were instructed to valuate healthy and unhealthy food products in combination with one of the two labels and to state their willingness to pay (WTP) for the product.ResultsThe labeling methods significantly influenced participants' WTP. Red TL signaling activated parts of the left inferior frontal gyrus/dorsolateral prefrontal cortex, a region implicated in self‐control in food choice. This region, in the case of red signaling, and the posterior cingulate cortex, in the case of green signaling, showed increased coupling to the valuation system in the ventromedial prefrontal cortex.ConclusionsOur results suggest that explicitly directing attention toward nutritional values using salient nutrition labels triggers neurobiological processes that resemble those utilized by successful dieters choosing healthier products.
Aven‐mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma
Authors: Baranski Zuzanna , Booij Tijmen H , Cleton‐Jansen Anne‐Marie , Price Leo S , van de Water Bob , Bovée Judith VMG , Hogendoorn Pancras CW , Danen Erik HJ 
Published: March 2015

AbstractConventional high‐grade osteosarcoma is the most common primary bone sarcoma, with relatively high incidence in young people. In this study we found that expression of Aven correlates inversely with metastasis‐free survival in osteosarcoma patients and is increased in metastases compared to primary tumours. Aven is an adaptor protein that has been implicated in anti‐apoptotic signalling and serves as an oncoprotein in acute lymphoblastic leukaemia. In osteosarcoma cells, silencing Aven triggered G2 cell‐cycle arrest; Chk1 protein levels were attenuated and ATR–Chk1 DNA damage response signalling in response to chemotherapy was abolished in Aven‐depleted osteosarcoma cells, while ATM, Chk2 and p53 activation remained intact. Osteosarcoma is notoriously difficult to treat with standard chemotherapy, and we examined whether pharmacological inhibition of the Aven‐controlled ATR–Chk1 response could sensitize osteosarcoma cells to genotoxic compounds. Indeed, pharmacological inhibitors targeting Chk1/Chk2 or those selective for Chk1 synergized with standard chemotherapy in 2D cultures. Likewise, in 3D extracellular matrix‐embedded cultures, Chk1 inhibition led to effective sensitization to chemotherapy. Together, these findings implicate Aven in ATR–Chk1 signalling and point towards Chk1 inhibition as a strategy to sensitize human osteosarcomas to chemotherapy. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.