bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palaeoproductivity linked to monsoon variability in the northern slope of the South China Sea from the last 290 kyr: evidence of benthic foraminifera from Core SH7B
Authors: Zhou Yang , Chen Fang , Wu Cong , Yu Shaohua , Zhuang Chang 
Published: November 2015

Abstract

A benthic foraminiferal proxy record of 290 kyr, acquired from Core SH7B in the northern continental slope of the South China Sea, was studied to identify the bottom-water environment changes since marine isotope stage (MIS) 8. The changes, including oxygenation and types of organic matter flux to the seafloor, reflect the palaeoproductivity fluctuations linked to monsoon variability. Four assemblages, characterizing different palaeoenvironmental changes, have been recognized by factor and cluster analysis with 32 foraminiferal species in 93 samples (>150 µm size fraction). Assemblage
Pyrgo
spp.–
Hoeglundina elegans
mainly dominates during interglacial periods of MIS 7, MIS 5 and MIS 3, suggesting well-oxygenated bottom environments with low sea surface productivity linked to a weak East Asian Winter Monsoon (EAWM). Assemblage
Uvigerina
spp.–
Globocassidulina subglobulosa
is composed of a constantly high percentage of shallow infaunal species, occurring in intervals of MIS 4, MIS 5, MIS 7 and MIS 8, which indicates that an enhanced EAWM led to a low seasonality of palaeoproductivity, a constant high flux of fresh and labile marine-derived organic particles to the seafloor and a low oxygen bottom environment. Assemblage
Melonis barleeanus
–
Clavulina
spp. is characterized by species that depend on seasonal supplies of more altered refractory organic matter and is mainly distributed in interglacial periods (late MIS 5, MIS 3 and MIS 1), suggesting a high seasonality of palaeoproductivity associated with a seasonal intensification of the EAWM. With low benthic foraminiferal diversity and abundance, assemblage
Globobulimina affinis
–
Chilostomella mediterranensis
was identified during the intermediate MIS 8 and early MIS 2. Both substantial input of terrigenous nutrients from an increased river run-off and an increased primary productivity correlated with an enhanced EAWM have led to abundant nutrient supplies and severe bottom-water oxygen depletion. As suggested by the composition of benthic foraminiferal in Core SH7B, changes in bottom-water environments of the northern South China Sea over the last 290 kyr were driven by the fluctuating palaeoproductivity linked to the high variability of the EAWM.
HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer
Authors: Xu Chun-Fang , Johnson Toby , Wang Xiaojing , Carpenter Chris , Graves Alan P. , Warren Liling , Xue Zhengyu , King Karen S. , Fraser Dana J. , Stinnett Sandy , Briley Linda P. , Mitrica Ionel , Spraggs Colin F. , Nelson Matthew R. , Tada Hiroomi , du Bois Andreas , Powles Thomas , Kaplowitz Neil , Pandite Lini N. 
Published: November 2015

Abstract
Purpose: Pazopanib is an effective treatment for advanced renal cell carcinoma and soft-tissue sarcoma. Transaminase elevations have been commonly observed in pazopanib-treated patients. We conducted pharmacogenetic analyses to explore mechanistic insight into pazopanib-induced liver injury.
Experimental Design: The discovery analysis tested association between four-digit HLA alleles and alanine aminotransferase (ALT) elevation in pazopanib-treated patients with cancer from eight clinical trials (N = 1,188). We conducted confirmatory analysis using an independent dataset of pazopanib-treated patients from 23 additional trials (N = 1,002). Genome-wide association study (GWAS) for transaminase elevations was also conducted.
Results: The discovery study identified an association between HLA-B*57:01 carriage and ALT elevation [P = 5.0 × 10−5 for maximum on-treatment ALT (MaxALT); P = 4.8 × 10−4 for time to ALT &gt; 3× upper limit of normal (ULN) event; P = 4.1 × 10−5 for time to ALT &gt; 5× ULN event] that is significant after adjustment for number of HLA alleles tested. We confirmed these associations with time to ALT elevation event (P = 8.1 × 10−4 for ALT &gt; 3× ULN, P = 9.8 × 10−3 for ALT &gt; 5× ULN) in an independent dataset. In the combined data, HLA-B*57:01 carriage was associated with ALT elevation (P = 4.3 × 10−5 for MaxALT, P = 5.1 × 10−6 for time to ALT &gt; 3×ULN event, P = 5.8 × 10−6 for time to ALT &gt; 5× ULN event). In HLA-B*57:01 carriers and noncarriers, frequency of ALT &gt; 3× ULN was 31% and 19%, respectively, and frequency of ALT &gt; 5× ULN was 18% and 10%, respectively. GWAS revealed a possible borderline association, which requires further evaluation.
Conclusions: These data indicate that HLA-B*57:01 carriage confers higher risk of ALT elevation in patients receiving pazopanib and provide novel insight implicating an immune-mediated mechanism for pazopanib-associated hepatotoxicity in some patients. Clin Cancer Res; 22(6); 1371–7. ©2015 AACR.
PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells
Authors: Mahoney Kathleen M. , Sun Heather , Liao Xiaoyun , Hua Ping , Callea Marcella , Greenfield Edward A. , Hodi F. Stephen , Sharpe Arlene H. , Signoretti Sabina , Rodig Scott J. , Freeman Gordon J. 
Published: November 2015

Abstract
Blocking the programmed death-1 (PD-1) pathway has clinical benefit in metastatic cancer and has led to the approval of the mAbs pembrolizumab and nivolumab to treat melanoma and nivolumab for non–small cell lung cancer. Expression of PD-L1 on the cell surface of either tumor cells or infiltrating immune cells is associated with a higher likelihood of response to PD-1 blockade in multiple studies. Most mAbs to PD-L1 in use are directed to its extracellular domain and immunohistochemically stain tumor tissue with a mixture of cytoplasmic and membrane staining. Cytoplasmic staining obscures the interpretation of a positive reaction on the tumor cell membrane, and thus affects the accuracy of PD-L1 scoring systems. We developed a mAb to the cytoplasmic domain of PD-L1, 405.9A11 (9A11), which is both more selective for membranous PD-L1 and more sensitive in IHC and Western blotting, compared with previous mAbs specific for the PD-L1 extracellular domain. Here, we compare immunohistochemical staining patterns of PD-L1 expression in five types of tumors, using five PD-L1 mAbs: 9A11, 7G11, and three commercially available mAbs. We demonstrate that 9A11, as well as two other cytoplasmic domain-specific mAbs, E1L3N and SP142, can clearly delineate the membrane of PD-L1–positive cells in formalin-fixed paraffin-embedded tissue and facilitate interpretation of staining results. Cancer Immunol Res; 3(12); 1308–15. ©2015 AACR.
The prevalence and age of onset of psychiatric disorders in Australian men
Authors: Williams Lana J , Jacka Felice N , Pasco Julie A , Coulson Carolyn E , Quirk Shae E , Stuart Amanda L , Berk Michael 
Published: November 2015

Objective: Given the burden of common psychiatric disorders and their consequent service and planning requirements, it is important to have a thorough knowledge of their distribution and characteristics in the population. Thus, we aimed to report the prevalence and age of onset of mood, anxiety and substance-use disorders in an age-stratified representative sample of Australian men. Method: Psychiatric disorders (mood, anxiety and substance-use disorders) were diagnosed utilising a structured clinical interview (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders–Fourth Edition, Non-Patient Edition) for 961 men aged 24–98 years enrolled in the Geelong Osteoporosis Study. The lifetime and current prevalence of these disorders was determined from the study population and standardised to 2006 census data for Australia. Results: Approximately one in three men (28.8%, 95% confidence interval [CI] = [26.8%, 30.8%]) reported a lifetime history of any psychiatric disorder, with mood disorders (18.2%, 95% CI = [15.2%, 21.2%]) being more prevalent than anxiety (7.2%, 95% CI = [5.0%, 9.4%]) and substance-use disorders (12.9%, 95% CI = [9.7%, 16.0%]). Approximately 8.7% (95% CI = [7.5%, 10.0%]) were identified as having a current disorder, with 3.8% (95% interquartile range [IQR] = [2.2%, 5.4%]), 2.4% (95% CI = [1.1%, 3.8%]) and 3.4% (95% CI = [1.8%, 4.9%]) meeting criteria for current mood, anxiety and substance-use disorders, respectively. The median age of onset for mood disorders was 37.5 years (IQR = 27.0–48.0 years), 25.0 years (IQR = 20.0–40.3 years) for anxiety and 22.0 years (IQR = 18.0–34.3 years) for substance-use disorders. Conclusion: This study reports the lifetime and current prevalence of psychiatric disorders in the Australian male population. These findings emphasise the extent of the burden of these disorders in the community.
Associations between recent gay-related stressful events, emotional distress, social support and unprotected anal intercourse behavior among Chinese men who have sex with men
Authors: Yunyong Liu , Zhe Wang , Junting Xu , Yan Zhou , Xiaoxia An , Li Zhao , Yuan Gu , Chao Jiang 
Published: November 2015

Background: This study was designed to assess the levels of and associations between gay-related stressful events, social support, emotional distress and the number of unprotected anal intercourse partners among Chinese men who have sex with men. Methods: Using a respondent-driven sampling method, 807 men who have sex with men were recruited in urban areas of northeast China and data were collected via face-to-face interviews. Gay-related stressful events were measured using the Gay-Related Stressful Life Events Scale; levels of depression, anxiety symptoms and social support were measured using the Self-Rating Depression Scale, the Self-Rating Anxiety Scale and the Social Support Rating Scale, respectively. Results: Over a quarter of study participants experienced gay-related stressful events during the preceding 3 months. Their average Self-Rating Depression Scale, Self-Rating Anxiety Scale and Social Support scores differed significantly from the national norm. Gay-related stressful events significantly correlated with anxiety ( r = 0.167, p < 0.001), depression ( r = 0.165, p < 0.001), social support ( r = −0.107, p = 0.002) and number of unprotected anal intercourse partners ( r = 0.13, p < 0.001), showing a clear dose–response relationship. Conclusion: Gay-related stressful events are common and are significantly associated with emotional distress, lack of social support and high-risk sexual behaviors among Chinese men who have sex with men. Multifaceted approaches are warranted to increase social support and reduce intolerance toward homosexual behaviors and to reduce risky sexual behaviors related to the rapid HIV epidemic among men who have sex with men population in China.
Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest
Authors: Lou Xin , Burrows Jeffrey T. A. , Scott Ian C. 
Published: November 2015

Abstract
Background
An intricate gene regulatory network drives neural crest migration and differentiation. How epigenetic regulators contribute to this process is just starting to be understood.

Results
We found that mutation of med14 or brg1 in zebrafish embryos resulted in a cluster of neural crest cell-related defects. In med14 or brg1 mutants, neural crest cells that form the jaw skeleton were specified normally and migrated to target sites. However, defects in their subsequent terminal differentiation were evident. Transplantation experiments demonstrated that med14 and brg1 are required directly in neural crest cells. Analysis of med14; brg1 double mutant embryos suggested the existence of a strong genetic interaction between members of the Mediator and BAF complexes.

Conclusions
These results suggest a critical role for Mediator and BAF complex function in neural crest development, and may also clarify the nature of defects in some craniofacial abnormalities.
Infrared-visible image registration for augmented reality-based thermographic building diagnostics
Authors: Liu Fei , Seipel Stefan 
Published: November 2015

AbstractBackgroundIn virtue of their capability to measure temperature, thermal infrared cameras have been widely used in building diagnostics for detecting heat loss, air leakage, water damage etc. However, the lack of visual details in thermal infrared images makes the complement of visible images a necessity. Therefore, it is often useful to register images of these two modalities for further inspection of architectures. Augmented reality (AR) technology, which supplements the real world with virtual objects, offers an ideal tool for presenting the combined results of thermal infrared and visible images. This paper addresses the problem of registering thermal infrared and visible façade images, which is essential towards developing an AR-based building diagnostics application.MethodsA novel quadrilateral feature is devised for this task, which models the shapes of commonly present façade elements, such as windows. The features result from grouping edge line segments with the help of image perspective information, namely, vanishing points. Our method adopts a forward selection algorithm to determine feature correspondences needed for estimating the transformation model. During the formation of the feature correspondence set, the correctness of selected feature correspondences at each step is verified by the quality of the resulting registration, which is based on the ratio of areas between the transformed features and the reference features.Results and conclusionsQuantitative evaluation of our method shows that registration errors are lower than errors reported in similar studies and registration performance is usable for most tasks in thermographic inspection of building façades.
Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis
Authors: Slaats Gisela G. , Wheway Gabrielle , Foletto Veronica , Szymanska Katarzyna , van Balkom Bas W. M. , Logister Ive , Den Ouden Krista , Keijzer-Veen Mandy G. , Lilien Marc R. , Knoers Nine V. , Johnson Colin A. , Giles Rachel H. 
Published: November 2015

ABSTRACT
To investigate the contribution of ion channels to ciliogenesis, we carried out a small interfering RNA (siRNA)-based reverse genetics screen of all ion channels in the mouse genome in murine inner medullary collecting duct kidney cells. This screen revealed four candidate ion channel genes: Kcnq1, Kcnj10, Kcnf1 and Clcn4. We show that these four ion channels localize to renal tubules, specifically to the base of primary cilia. We report that human KCNQ1 Long QT syndrome disease alleles regulate renal ciliogenesis; KCNQ1-p.R518X, -p.A178T and -p.K362R could not rescue ciliogenesis after Kcnq1-siRNA-mediated depletion in contrast to wild-type KCNQ1 and benign KCNQ1-p.R518Q, suggesting that the ion channel function of KCNQ1 regulates ciliogenesis. In contrast, we demonstrate that the ion channel function of KCNJ10 is independent of its effect on ciliogenesis. Our data suggest that these four ion channels regulate renal ciliogenesis through the periciliary diffusion barrier or the ciliary pocket, with potential implication as genetic contributors to ciliopathy pathophysiology. The new functional roles of a subset of ion channels provide new insights into the disease pathogenesis of channelopathies, which might suggest future therapeutic approaches.
Swimming against the tide: Women's experience of choosing a homebirth in Switzerland
Authors: Brailey Sue , Jarrett Patricia , Luyben Ans , Poat Angela 
Published: November 2015

Background: Choice in childbirth, which also involves choice of place to give birth, is a fundamental right of all women. Despite the availability of health-care options for maternity services, most women living in Switzerland continue to give birth in hospital. This paper explores factors influencing the decision of Swiss women to give birth at home. Study design: A descriptive qualitative study was used. Semi-structured interviews were conducted with six pregnant women living in Switzerland who were planning a homebirth. Data were analysed using thematic analysis. Findings: Previous hospital experience, expectations of homebirth, women's attitudes to birth, and personal and societal influences were reasons women gave for choosing a homebirth. Homebirth offered women more autonomy, less medical intervention, and a more relaxing environment than traditional hospital settings. Conclusion: Women in Switzerland who choose homebirth are motivated by the same factors as women elsewhere. The findings from this study suggest a need for personalised maternity care which supports women in their childbirth choices.
Short- and Long-term Biologic Variability of Galectin-3 and Other Cardiac Biomarkers in Patients with Stable Heart Failure and Healthy Adults
Authors: Schindler Emily I , Szymanski Jeffrey J , Hock Karl G , Geltman Edward M , Scott Mitchell G 
Published: November 2015

AbstractBACKGROUNDGalectin-3 (Gal-3) has been suggested as a prognostic biomarker in heart failure (HF) patients that may better reflect disease progression than traditional markers, including B-type natriuretic peptide (BNP) and cardiac troponins. To fully establish the utility of any biomarker in HF, its biologic variability must be characterized.METHODSTo assess biologic variability, 59 patients were prospectively recruited, including 23 male and 16 female patients with stable HF and 10 male and 10 female healthy individuals. Gal-3, BNP, and high-sensitivity cardiac troponin I (hs-cTnI) were assayed at 5 time points within a 3-week period to assess short-term biologic variability. Long-term (3-month) biologic variability was assessed with samples collected at enrollment and after 4, 8, and 12 weeks.RESULTSAmong healthy individuals, mean short-term biologic variability, expressed as intraindividual CV (CVI), was 4.5% for Gal-3, 29.0% for BNP, and 14.5% for hs-cTnI; long-term biologic variability was 5.5% for Gal-3, 34.7% for BNP, and 14.7% for hs-cTnI. In stable HF patients, mean short-term biologic variability was 7.1% for Gal-3, 22.5% for BNP, and 8.5% for hs-cTnI, and mean long-term biologic variability was 7.7% for Gal-3, 27.6% for BNP, and 9.6% for hs-cTnI.CONCLUSIONSThe finding that Gal-3 has minimal intraindividual biological variability adds to its potential as a useful biomarker in HF patients.
Applications of light speed expansion and gravitational self-energy density in black hole cosmology
Authors: UV Satya Seshavatharam , E Terry Tatum , S Lakshminarayana 
Published: November 2015

From the beginning of Planck scale to the scale of the current Hubble radius: 1) Considering the relation, subjects of black holes and cosmology, both can be integrated into evolving black hole cosmology and cosmic horizon problem can be relinquished. 2) Considering â€˜continuous light speed expansionâ€™ of the cosmic black hole horizon, attributed results of cosmic inflation can be re-addressed completely. If â€˜natureâ€™ of the universe is to expand with light speed, then there is no need to think about the existence of currently believed â€˜Lambda termâ€™. In addition, â€˜light speed expanding cosmic spaceâ€™ can be called as â€˜flat spaceâ€™. 3) Considering the ratio of gravitational self-energy density and thermal energy density to be Â (where Â is the Planck scale temperature, and is cosmic temperature at any time). Quantum gravity can be implemented in low energy scale current cosmological observations. Considering the above concepts, currently believed dark matter energy density and visible matter energy density both can be accurately fitted with the ratio of current gravitational self-energy density and current thermal energy density. To proceed further, the authors would like to highlight the following three points: 1) Deep-space red shift non-linearity can be expected to be connected with cosmological gravitational and relativistic effects and cannot be considered as a major criterion of cosmic evolution. 2) Until one finds solid applications of super luminal speeds and super luminal expansions in other areas of physics like astrophysics and nuclear astrophysics, currently believed â€˜cosmic inflationâ€™ cannot be considered as a real physical model and alternative proposals of inflation can be given a chance in exploring the evolving history of the universe. 3) Implementing Planck scale in current paradigm of cosmological observations and standard cosmology is very challenging and is inevitable.
Efficiency Of Technical And Tactical Approach To Teaching Minihandball Game Skills In Different Age Categories
Authors: Priklerová Silvia , Kucharik Ivan 
Published: November 2015

Summary
The aim of the study was to verify the efficiency of a traditional (technical) approach and a tactical game based approach to teaching minihandball game skills the first- to fourth-grade elementary school pupils. The experimental design was two parallel-group trials. Experimental groups (EG) were taught by the tactical approach where modified and small-sided games comprised 80 % and drill-exercises 20 % of all the units. Control groups (CG) were taught by the technical approach where drill exercises comprised 70 % and modified and small-sided games 30 % of all the units. Two groups of first- and second-graders (EG n=16, CG n=17) and two groups of third- and fourth-graders (both EG and CG n=12) attending extracurricular activities oriented to minihandball participated in the study. The technique of offensive game skills (overarm pass, dribbling and shot) was evaluated by 1 to 5 scoring system. For statistical analysis, Wilcoxon’s T-test and Man-Whitney’s U-test were used and the level of significance was set to 5 %. Based on the results it can be stated that the tactical approach is as efficient as a technical approach on game skills’ technique acquirement. Results showed significant changes in the technique of game skills in both age categories (p<0.01). No significant differences between age categories were confirmed in game skill tests besides the dribbling test where the older experimental group (third- and fourth-graders) achieved better performance than the younger experimental group (first- and second-graders).
Modelling And Numerical Analysis Of Assembly System
Authors: Budniak Zbigniew 
Published: November 2015

Abstract
The present articles covers a concept of the creation and testing of assembly systems with the use of modern CAD and CAE systems on the example of an assembly system designed for joining parts with circular surfaces that are fitted with positive clearance. The numerical investigations were based on the constructed spatial skeleton pattern of the system. The purpose of the simulation tests was to determine the impact of the measurement and angular inaccuracies of all the elements of the assembly system as well as the inaccuracy of the positioning of the robot’s drives on the positioning accuracy of the parts joined taking into consideration the conditions of assembly in automatic assembly.
Antiplane Deformation Of A Bimaterial Containing An Interfacial Crack With The Account Of Friction 2. Repeating And Cyclic Loading
Authors: Sulym Heorhiy , Piskozub Lyubov , Piskozub Yosyf , Pasternak Iaroslav 
Published: November 2015

Abstract
The paper presents the exact solution of the antiplane problem for an inhomogeneous bimaterial with the interface crack exposed to the normal load and cyclic loading by a concentrated force in the longitudinal direction. Using discontinuity function method the problem is reduced to the solution of singular integral equations for the displacement and stress discontinuities at the domains with sliding friction. The paper provides the analysis of the effect of friction and loading parameters on the size of these zones. Hysteretic behaviour of the stress and displacement discontinuities in these domains is observed.