bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Correlation of Kampo Formulations and Their Ingredients on Anti‐bacterial Activities against Propionibacterium acnes
Authors: Higaki Shuichi , Hasegawa Yoshinori , Morohashi Masaaki , Takayoshi Yamagishi 
Published: April 2015

AbstractThe correlation between the susceptibilies of Propionibacterium acnes strains to two Kampo formulations and these to their ingredients (Kampo crude drugs) was examined. Two out of 19 Kampo crude drugs, Coptidis Rhizoma (CR) and Phellodendri Cortex (PC), inhibited the growth of P. acnes significantly. The patterns of distribution of the minimal inhibitory concentrations of Keigai‐rengyo‐to (KRT) and of Seijo‐bofu‐to (SBT) were almost the same as those of the Kampo crude drugs, except CR and PC.Furthermore, no correlations between MICS of Kampo formulations and those of their ingredients against P. acnes were found. This might be due to mutual inhibition or to differences in anti‐bacterial mechanisms between the two Kampo formulations and their ingredients. The Kampo formulations, composed of CR, PC and a few other kinds of Kampo crude drugs, might be more susceptible against P. acnes, since higher concentrations of the effective ingredients can be achieved.
Histopathologic and Ultrastructural Studies of Angiokeratoma Corporis Diffusum in Kanzaki Disease
Authors: Yokota Michiko , Koji Masato , Yotsumoto Shinichi 
Published: April 2015

AbstractA novel metabolic disease, angiokeratoma corporis diffusum (Kanzaki), was the subject of an extensive histopathologic and ultrastructural study. Findings included dilated lymph and blood vessels in the upper dermis with an orthokeratortic, thickened, horny layer in well developed angiokeratoma. In the early papules, a few sporadic dyskeratotic keratinocytes were present in the epidermis with or without a thickened horny layer. Vesicular clear vacuolation was clearly observed in the cytoplasm of the secretory portion of the eccrine sweat glands, but none was observed in the vascular endothelial cells with hematoxylin‐eosin staining. Using electron microscopy, lysosomal vacuolation was observed in many cell types, including eccrine sweat gland cells, vascular endothelial cells, dermal fibroblasts, dermal neural cells, lymphocytes of peripheral blood in the skin, and glomerular endothelial cells, but none was noted in the epithelial cells of the kidney. Widely dilated vacuoles were found to contain only a small amount of fuzzy filamentous material in the vascular endothelial cells, filamentous or electron‐dense granular substances in fibroblasts, and electron‐dense, lamellated or homogeneous structures in eccrine sweat gland cells and in neural cells. Ultracytochemical examination revealed glycoconjugates in dilated lysosomes. Characteristics of Kanzaki Disease were shown to differ from those of Fabry disease or any other lysosomal storage disease.
A Case of Urticarial Vasculitis Associated with Macroglobulinemia (Schnitzler's Syndrome)
Authors: Morita Akimichi , Sakakibara Shigeru , Yokota Michiko , Tsuji Takuo 
Published: April 2015

AbstractWe report a case of urticarial vasculitis associated with macroglobulinemia in a 50‐year‐old woman. She suffered from intermittent fever with wheals persisting for more than 24 hours. Skin histology revealed perivascular neutrophilic infiltrates with nuclear dusts. Laboratory study demonstrated leucocytosis and a high serum IgM level (2350 mg/dl) with an M component. No overt lymphoid proliferative disease was found. As far as we know, this is the first report of such a case in Japan. Predonizolone and nonsteroidal anti‐inflammatory drugs have proved transiently effective for controlling the urticaria, but not for the IgM gammopathy.
Cortisol Status in Different Types of Leprosy
Authors: Bansal Rakesh , Garg Bhagat R. , Adithan C. , Vasireddi Srinivas S. , Kumar Vijay , Chandra Dinesh 
Published: April 2015

AbstractBasal plasma cortisol levels in 12 controls and 60 patients with different types of leprosy were within normal limits. They were significantly lower in multibacillary leprosy patients; this abnormality might be due to long standing stress leading to adrenal exhaustion. The plasma cortisol level significantly increased after the ACTH (Synacthen) stimulation test in all of the varieties of leprosy tested, which suggests that the adrenal reserve is maintained in such cases.
Remission of Pustular Psoriasis after Cholecystectomy: Role of Focal Infection in Pustularization of Psoriasis
Authors: Nomura Kumiko , Mizutani Hitoshi , Inachi Shin , Shimizu Masayuki 
Published: April 2015

AbstractWe report an 81‐year‐old male with long lasting psoriasis with exacerbation who showed remission of skin lesions after cholecystectomy. He consulted our clinic for impetiginous skin lesions and was treated with oral antibiotics without improvement. Several days later, he developed right hypochondralgia and was diagnosed with acute cholecystitis with gallstones. After cholecystectomy, the skin lesions significantly improved and disappeared within three weeks. Laboratory examination data indicated that acute inflammatory parameters normalized simultaneously. Although the role of focal infection in psoriasis is obscure, our case emphasizes the importance of focal infection in the pathogenesis of unstable psoriasis.
Treatment of Cutaneous Sarcoidosis with Tranilast
Authors: Yamada Haruyoshi , Ide Akiko , Sugiura Makoto , Tajima Shingo 
Published: April 2015

AbstractTranilast is an anti‐allergic drug clinically used for the treatment of atopy or urticaria. The drug has been shown to have an anti‐fibrotic effect as well. We treated two cutaneous sarcoidosis patients with tranilast, resulting in remission within three months of administration. This drug should be an excellent tool for the treatment of other granulomatous diseases.
Staphylococcus aureus Isolated from Nostril Anteriors and Subungual Spaces of the Hand: Comparative Study of Medical Staff, Patients, and Normal Controls
Authors: Namura Shoko , Nishijima Setsuko , Higashida Toshiaki , Asada Yasuo 
Published: April 2015

AbstractAn epidemiologic investigation of methicillin‐resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus (S. aureus) colonization was conducted at Kansai Medical University Hospital between 1990 and 1991. The incidence of nasal and subungual positivity for S. aureus was examined in a total of 156 subjects including inpatients, physicians, and nurses at a ward for dermatology, plastic surgery, and emergency patients, outpatients with atopic dermatitis and other skin diseases, and normal controls. Inpatients were most heavily colonized with MRSA (40.8%), but S. aureus colonization was most frequent in outpatients with atopic dermatitis (95.5%). Not only nostrils, which have been much discussed as a reservoir of S. aureus, but also subungual spaces seemed to be havens of S. aureus. Twelve out of 22 atopic dermatitis patients were positive for S. aureus on skin regions, and coagulase and phage testing showed a correlation between the nasal and skin‐colonizing S. aureus. Coagulase type II and phase type NT (not typable) were the predominant types of S. aureus, including MRSA.
Verrucous Plaque: Unique Morphological Expression of Post‐Kala‐Azar Dermal Leishmaniasis (PKDL)
Authors: Gautam Ram K , Sehgal Virendra N. , Singh Navjeevan 
Published: April 2015

AbstractRelatively unusual verrucous plaque as well as other expressions of P.K.D.L. are reported in a 46‐year‐old male. The diagnosis was confirmed by the documentation of Leishman‐Donovan bodies in the tissue smears as well as in the cytoplasm of the histiocytes in the tissue section.
A Case of Bowen's Disease with Tissue Eosinophilia
Authors: Nakayama Hidetoshi , Mihara Motoyuki , Mishima Erika , Shimao Shuhei 
Published: April 2015

AbstractAn 85‐year‐old Japanese man with Bowen's disease on the left inguinal area is reported. Most of the inflammatory cells adjacent to the tumor were eosinophils. Tissue eosinophilia spontaneously improved after biopsy.
Bilateral Basal Cell Carcinoma of the Breasts in a Woman
Authors: Núñez María , Marqués Alicia , de las Heras M. Elena , Miralles Enrique S. , Ledo Antonio 
Published: April 2015

AbstractBasal cell carcinomas (BCC) on covered sites of the body are rare (1). A case of a young woman with superficial basal cell carcinoma of both breasts is described. No history of sun bathing, X‐ray, or arsenical exposure was reported. Simple excision of both lesions was performed without recurrence.
Elevated Serum Insulin‐like Growth Factor‐1 (IGF‐1) Levels in Women with Postadolescent Acne
Authors: Aizawa Hiroshi , Niimura Michihito 
Published: April 2015

AbstractThe purpose of this study was to measure the serum levels of IGF‐1 in women with postadolescent acne compared to normal controls, and evaluate the relationship of these levels to the levels of androgens, in order to investigate the possible role of IGF‐1 in the pathogenesis of acne. Eighty‐two female patients with acne between 20 and 25 years of age and thirty‐one age‐matched control women were studied. We measured the serum levels of total testosterone (T), free testosterone (FT), dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA‐S), and insulin‐like growth factor‐1 (IGF‐1).The levels of IGF‐1 in patients with acne (1.26 ± 0.52 U/ml) were significantly (p<0.001) increased over those of controls (0.96 ± 0.32 U/ml). Of 82 acne patients, six (7%) had IGF‐1 levels which exceeded the normal range, but there were no significant correlations between IGF‐1 and T, FT, DHT or DHEA‐S levels or between IGF‐1 and acne severity. Since the measurement of serum IGF‐1 levels is a convenient indicator of GH secretion, the increase of serum IGF‐1 levels seen in some acne patients might reflect an increase of GH.
A Case of Linear Type of Lichen Sclerosus et Atrophicus?
Authors: Izumi Tatsuya , Tajima Shingo 
Published: April 2015

AbstractWe report a case of the linear type of lichen sclerosus et atrophicus (LSA). The patient had linear atrophic lesions from the left upper back to the left hand. Histological findings obtained from the upper back were those of typical LSA. Histology of the forearm showed mild changes suggestive of LSA. There were no histological features suggesting any association with localized scleroderma in either specimen. The relation between LSA and localized scleroderma is unclear at present. This case suggests that there is a linear form in LSA as already recognized in localized scleroderma.
Ichthyosis Bullosa of Siemens: Report of a Sporadic Case
Authors: Kim Soo‐Chan , Hur Won , Won Jin Hyoung , Ahn Sung Ku 
Published: April 2015

AbstractWe report a sporadic case of ichthyosis bullosa of Siemens occurring in a Korean boy. In this report, the varied findings of the clinical features in one subject over five years are presented along with an investigation of the ultrastructural alteration. The patient had suffered from blistering, superficial peeling, and dark‐grey colored lichenified patches on the extremities since infancy. As he grew older, the lesions were more localized to the elbows, knees, buttock and the dorsal aspects of the hands and feet, and were replaced by yellowish, lichenified plaques. Since the original report of Siemens in 1937, nine families including one sporadic case have been reported in the literature. To our knowledge, this is the second report of sporadic case of IBS.
Serum Levels of Soluble CD23 in Patients with Bullous Pemphigoid
Authors: Maekawa Noriko , Hosokawa Hiroshi , Soh Hiromu , Kasahara Mika , Izumi Hiroshi , Yodoi Junji , Asada Yasuo 
Published: April 2015

AbstractIn this study, we tested the serum levels of soluble CD23 (sCD23) in 27 bullous pemphigoid (BP) patients and compared them with the disease activity. Soluble CD23 is the cleaved portion of the low affinity Fc receptor for IgE (FcɛRII/CD23) which has an affinity for IgE and regulates IgE synthesis. Although bullous pemphigoid (BP) is a subepidermal blistering disease characterized by IgG class autoantibodies against the basement membrane of stratified squamous epithelia, several IgE‐related phenomena have been reported. Recently, we have shown that FcɛRII‐expressing and IgE‐bearing cells are detectable in the lesional skin and concluded that an IgE‐FcɛRII/CD23 system may be involved in the pathogenesis of this disease.The serum level of sCD23 in BP patients was significantly higher than healthy controls (p<0.01). In 11 out of 12 patients, the alteration of serum sCD23 levels correlated well with the disease activity. Thus the serum level of sCD23 is useful as a new parameter for assessing the level of disease activity in BP. High levels of sCD23 may represent part of an IgE‐mediated immune reaction which may play a role in the pathogenesis of BP.
The Atrophic Dermatofibroma: A Delled Dermatofibroma
Authors: Requena Luis , Reichel Martin 
Published: April 2015

AbstractAtrophic dermatofibroma has been proposed as a term to designate a new and specific type of dermatofibroma. We report the clinical and histopathological findings in two cases of atrophic dermatofibroma. The peculiar morphology of these lesions simply represents a conspicuous example of the frequently seen central depression in dermatofibroma. On histopathology, no authentic atrophy is present, because the thinning of the dermis compared with that of the adjacent non‐lesional skin results from this depression rather than from loss of tissue of the dermis. Delled dermatofibroma is a more appropriate appellation than atrophic dermatofibroma, because of the striking shape of these lesions.
Primary Lymphocutaneous Nocardiosis Due to Nocardia otitidiscaviarum: The First Case Report from Japan
Authors: Suzuki Yutaka , Toyama Keiji , Utsugi Kouichi , Yazawa Katsukiyo , Mikami Yuzuru , Fujita Masaru , Shinkai Hiroshi 
Published: April 2015

AbstractWe report a case of lymphocutaneous syndrome caused by Nocardia otitidiscaviarum (formerly known as N. caviae) in a 78‐year‐old woman who underwent long‐term therapy with prednisolone for bronchial asthma. Histological examination showed granulomatous reaction with multiple polymorphonuclear leukocytes and revealed a Gram positive filament in the dermis. Grampositive, slightly acid‐fast branched filaments were also found in the smear of the purulent material. The cell wall constituents of the isolate were meso‐diaminopimelic acid, arabinose, and galactose; the mycolic acid pattern of the isolate was Nocardia type. The organism decomposed xanthine and hypoxanthine, but not tyrosine or casein, which distinguished it from N. asteroides and N. brasiliensis. The skin lesions responded to minocycline and later to a combination of doxycycline and ofloxacin. This primary lymphocutaneous nocardiosis due to N. otitidiscaviarum is the first in Japan.
Treatment of Granuloma Annulare with Tranilast
Authors: Yamada Haruyoshi , Ide Akiko , Sugiura Makoto , Kurihara Sei‐ichi , Tajima Shingo 
Published: April 2015

AbstractThree cases of granuloma annulare which did not exhibit a self‐limited course were treated with tranilast at the dose of 300 mg/daily. The treatment resulted in the resolution of skin lesions within three months of administration. Although spontaneous resolution is often observed in granuloma annulare, tranilast may provide an alternative therapy for the treatment of cases resistant to spontaneous healing.
Group D Xeroderma Pigmentosum: A Case with a Number of Nevocellular Nevi
Authors: Inoue Yuji , Yamaizumi Masaru , Ono Tomomichi 
Published: April 2015

AbstractA 12‐year‐old boy was diagnosed as having group D xeroderma pigmentosum based on the results of unscheduled DNA synthesis (UDS) tests and complementation tests. More than 200 moles were distributed all over his body, including the unexposed areas of his torso and scalp. All of eight removed specimens were compatible histologically with nevocellular nevi.
Acquired Coccygeal Nodule Due to Repeated Stimulation by a Bicycle Saddle
Authors: Nakamura Atsushi , Inoue Yuji , Ishihara Tsuyoshi , Matsunaga Wakatoshi , Ono Tomomichi 
Published: April 2015

AbstractFour Japanese male students, aged 14, 16, 18 and 19, were found to have a nodule in their coccygeal regions. The typical lesion was a rugby‐ball‐shaped, normal‐colored or slightly erythematous nodule measuring 5 to 6 cm in its long axis. Histopathologically, it showed hyperplasia of collagen fibers and slight acanthosis. All four students rode to school by bicycle over long distances and long periods; three of them developed the nodule after they started bicycle riding to school. We found that the nodule shape corresponded to the saddle of the bicycle. X‐ray abnormalities included bending or anterior dislocation of the coccyx in all cases and spina bifida in two cases. These nodules may have developed as a result of irritation of this region by the saddle of the bicycle.
Detection of Epidermal Cellular DNA Content and Its Clinical Significance in Psoriasis Vulgaris
Authors: Ke‐Jian Zhu , Tie‐Cheng Zhu 
Published: April 2015

AbstractEpidermal cellular DNA content was detected by flow cytometry on 14 samples of normal skin and both lesional and nonlesional areas of 36 patients with psoriasis vulgaris. The results showed that the proliferative activity of epidermal cells increased in nonlesions and even more in lesions of patients from the levels in normal skin. These differences were significant (p<0.05). Clinical features and histopathological changes were observed, and self comparisons of 6 patients before and after treatment were also done. The clinical significance of these changes was discussed.
A Case of Steatocystoma Multiplex with Prominent Cysts on the Scalp Treated Successfully Using a Simple Surgical Technique
Authors: Kanekura Takuro , Kawamura Kyoko , Nishi Masayuki , Kanzaki Tamotsu 
Published: April 2015

AbstractThe case described is a 35‐year‐old male with multiple cysts on the upper half of his body. This patient was diagnosed as having steatocystoma multiplex, based on clinical and histological findings. The lesions consisted of widespread and unusually prominent cysts, which were removed by a simple surgical technique using a dermatological trepan and artery forceps. We provide here a detailed description of the surgical procedures employed.
Primary Cutaneous Ki‐1+ Anaplastic Large Cell Lymphoma: A Morphologic, Immunohistochemical and Genetic Study of an Indolent Case
Authors: Sato Noriko , Sato Kazunari , Yagi Eiichi , Tomita Yasushi 
Published: April 2015

AbstractA 59‐year‐old woman with a large nodular ulcerative lesion on her neck was presented. She had a 3 year history of recurrent cutaneous nodules which spontaneously regressed before regional lymphadenopathies appeared. She has followed an indolent clinical course for seven years after the first overt lymphadenopathies appeared. Histological findings were compatible with anaplastic large cell lymphoma (ALCL). The tumor cells strongly expressed Ki‐1 (CD30), HLA‐DR, IL‐2 receptor (CD25) and leukocyte common antigen. These findings led to the diagnosis of primary cutaneous Ki‐1+ ALCL. Although the majority of the tumor cells did not express T‐cell related antigens, the detection of monoclonal TCR gene rearrangement clearly established the T‐cell lineage nature.
Coexistence of Subepidermal Calcified Nodule and Keratosis Punctata in a Patient with Hyperhidrosis
Authors: Yamamoto Toshiyuki , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractA 47‐year‐old female with hyperhidrosis developed multiple subepidermal calcified nodules and keratosis punctata on her palms. Although calcification was not detected on eccrine sweat glands around the calcified mass by histologic examination, it was supposed that the eccrine sweat glands may have played a role in inducing these two lesions in our case.
Statistical Survey from 1982 to 1991 of 49 Patients with Malignant Melanocytic Tumors
Authors: Ueda Eiichiro , Kishimoto Saburo , Yasuno Hirokazu 
Published: April 2015

AbstractWe investigated the clinical characteristics and outcome of 49 patients with malignant melanoma: 17 with acral lentiginous melanoma, 14 with nodular melanoma, six with superficial spreading melanoma, one with lentigo maligna melanoma, eight with melanoma in situ, one with malignant blue nevus, and two with melanoma of unknown origin. Of the 41 patients without melanoma in situ, 34.1% were in stage I, 17.1% in stage II, and 48.8% in stage III. No patients had reached stage IV. All patients with stage I, II, and III melanoma were treated with wide resection, lymph node dissection including prophylactic dissection, and combination chemotherapy with dacarbazine, nimustine hydrochloride, and vincristine (DAV) with or without Interferon‐β. The statistical analysis revealed that tumor thickness and level of invasion were factors significantly associated with outcome. A gradual increase in the number of new cases of melanoma was seen each year of the registration period (1982–1991); there was an approximately 4‐fold increase during this decade over the previous decade. The majority of the primary lesions (80.5%) were located on the upper or lower extremities, the pT4 tumor thickness subgroup was the most frequent (39.0% of all melanomas), and invasion level IV was the most common (42.5%). About half (51.2%) of the melanoma patients were stage I or II; this group had a 5‐year survival rate of 100%. The stage III patients had a 5‐year survival rate of only 54.2% (p<0.05).
Clinico‐Epidemiological Profile of Ichthyosis in South Indian Patients
Authors: Baruah Manik C. , Oeducoumar P. , Garg Bhagat R. , Kumar Vijay 
Published: April 2015

AbstractA high frequency rate of hereditary ichthyosis (141.89 per 1000) was detected in a 1029 member South Indian study population selected at random from the skin outpatients of a teaching hospital. An age and sex matched control population screened from the medical and pediatric outpatients of the same institute recorded the incidence of ichthyosis vulgaris as 150 per 1000 population which is even higher.
Striated Muscle Hamartoma of the Nostril
Authors: Nakanishi Hideki , Hashimoto Ichiro , Takiwaki Hirotsugu , Urano Yoshio , Arase Seiji 
Published: April 2015

AbstractWe observed two females, an 11‐month old and a 15‐year‐old, each with a round, soft mass in the nostril. Histologically, numerous bundles of striated muscle fibers were seen in the masses among normal dermal components. The lesions were excised without complications. Four patients with similar lesions confirmed clinically and histologically have been reported in the literature under various diagnostic names. These masses were diagnosed as striated muscle hamartomas in view of their characteristic features: congenital round, soft masses on the midline of the head or neck with multiple, mature striated muscles observed in the mass. Since these lesions may be associated with such anomalies as amniotic band syndrome and lipoma of the brain, a complete medical examination is required of such patients.
Scleroderma‐like Changes in a Patient with Insulin‐Dependent Diabetes Mellitus
Authors: Maekawa Yoshihiro , Nakamura Takehiko , Nogami Reiko 
Published: April 2015

AbstractA 38‐year‐old Japanese woman with diabetes showed sclerosis of the hands, a short sublingual frenulum, and hypomotility of the esophagus. She had been on insulin therapy for insulin‐dependent diabetes mellitus since the age of 15. For the previous one year, the proximal interphalangeal joints had become painful and swollen with sclerosis of the hands. Although these findings are also seen in PSS, this case was assumed to be due to diabetes mellitus. The patient had a high serum level of HbAlc, which may reflect a poor control of diabetes and non‐enzymatic glycosylation of collagen fibers, resulting in an accumulation of collagen in the dermis.
Pyoderma Gangrenosum with Systemic Involvement
Authors: Urano Shoko , Kodama Hiroyuki , Kato Kazuaki , Nogura Kazuya 
Published: April 2015

AbstractWe report a case of a patient with pyoderma gangrenosum associated with multisystemic manifestations. The patient showed liver dysfunction, respiratory failure, and aseptic meningeal reaction. Corticosteroid therapy was efficient in treating both the skin lesions and the other systemic disorders.