bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desempenho dos municípios brasileiros nas dimensões do ranking da qualidade da informação contábil e fiscal e a percepção dos profissionais contábeis sobre o tema
Authors: Lima Diana Vaz de , Reis Celina Costa Lima dos , Fialho Gustavo Ferreira , Neves Rodrigo Pereira 
Published: July 2024

Objetivo: Analisar o desempenho dos municípios brasileiros nas dimensões do Ranking da Qualidade da Informação Contábil e Fiscal no Siconfi (Ranking) e avaliar a percepção dos profissionais contábeis sobre o tema.
Metodologia: Para analisar o desempenho dos municípios nas dimensões do Ranking, foi efetuada coleta de dados no sítio da Secretaria do Tesouro Nacional (https://www.tesourotransparente.gov.br/visualizacao/Ranking-da-qualidade-da-informacao-contabil-e-fiscal-estadual) relativos aos exercícios de 2020 a 2023. Para avaliar a percepção dos profissionais contábeis municipais sobre o tema, foi aplicado questionário estruturado com quatro perguntas, elaboradas com o objetivo de capturar a percepção desses profissionais sobre a existência do Ranking, o conhecimento deles quanto aos dados relativos aos municípios em que trabalhavam e eventuais medidas tomadas pelo município para melhorar a nota atribuída pela STN. Os Municípios foram contatados pela equipe de Call Center da Confederação Nacional de Municípios, devidamente instruída pela equipe de pesquisa.
Resultados: A pesquisa mostra que a Dimensão IV (que compara a Declaração de Contas Anuais, Matriz de Saldos Contábeis e relatórios da Lei de Responsabilidade Fiscal) apresentou o menor percentual de acertos no triênio, revelando problemas na consistência dos dados quando as informações entre relatórios diferentes são comparadas. Com a realização do questionário foi colhido como achado que 40% dos respondentes desconheciam o Ranking e mesmo entre os que não o conhecia 46% não realizaram ações para melhorar a colocação do município no Ranking, revelando o desinteresse dos profissionais ou dos gestores municipais sobre a sua importância no contexto de indicadores da qualidade da informação contábil.
Contribuições do Estudo: Este artigo indica a necessidade de ampliar as pesquisas empíricas sobre a qualidade dos dados contábeis municipais, buscando aperfeiçoar as questões apresentadas no questionário realizado, incluindo, por exemplo, itens que avaliam a melhoria no sistema contábil.
SLC16A3 is a Prognostic Marker and Affects Immune Regulation in Bladder Cancer
Authors: Li Chengjun , Chu Guangdi , Ma Guofeng , Chen Xinlei , Ma Xiaocheng , Niu Haitao 
Published: July 2024

Background:
Overexpression of SLC16A3 can contribute to the development of various
tumors by regulating metabolism, but a systematic analysis of SLC16A3 in bladder cancer
(BC) has been rarely reported.

Methods:
We used the BC datasets from public databases to investigate SLC16A3 expression in
BC. We first analysed the relationship between SLC16A3 expression and clinical characteristics
of 412 bladder cancer patients. After that, gene function analyses and immunocorrelation analyses
of SLC16A3 were conducted with the R package. For immunotherapy effect and drug sensitivity
analysis, we also used the R package. We also analysed the relation between SLC16A3
expression and 20 m6A modification key genes. Finally, we determined the expression localization
of SLC16A3 in bladder cancer by single-cell sequencing analysis using 3,115 BC cells. We
further detected the expression of SLC16A3/MCT4 on BC samples by reversed transcriptionquantitative
polymerase chain reaction and immunohistochemistry.

Results:
The SLC16A3 was overexpressed in BC cells, including epithelial cells (p＜0.001).
The high SLC16A3 expression level of patients with BC was significantly related to poor prognosis
(p＝0.044), and we established a reliable prognosis model for BC patients. Statistically
significant associations between SLC16A3 and m6A modification (ALKBH5) gene (p＜0.001),
key genes in aerobic glycolysis, M2 macrophage infiltration (p＝0.0058), and immune checkpoint
regulation were observed.

Conclusion:
Overexpression of SLC16A3 is an independent prognostic factor in patients with
BC. SLC16A3 may influence the immune infiltration of BC by regulating BC metabolism and
m6A methylation, which ultimately can lead to the progress of BC. For the detection and therapy
of BC, SLC16A3 may be a potent therapeutic target for BC.
Molecular Mechanisms Underlying the Therapeutic Potential of Plant-Based α-Amylase Inhibitors for Hyperglycemic Control in Diabetes
Authors: Kaur Amritpal , Singh Shareen , Mujwar Somdutt , Singh Thakur Gurjeet 
Published: July 2024

Background:
Diabetes mellitus (DM), arising from pancreatic β-cell dysfunction and
disrupted alpha-amylase secretion, manifests as hyperglycemia. Synthetic inhibitors of alphaamylase
like acarbose manage glucose but pose adverse effects, prompting interest in plantderived
alternatives rich in antioxidants and anti-inflammatory properties.

Objective:
The current review investigates plant-based alpha-amylase inhibitors, exploring their
potential therapeutic roles in managing DM. Focusing on their ability to modulate postprandial
hyperglycemia by regulating alpha-amylase secretion, it assesses their efficacy, health benefits,
and implications for diabetes treatment

Methods:
This review examines plant-derived alpha-amylase inhibitors as prospective diabetic
mellitus treatments using PubMed, Google Scholar, and Scopus data

Results:
Plant-derived inhibitors, including A. deliciosa, B. egyptiaca, and N. nucifera, exhibit
anti-inflammatory and antioxidant properties, effectively reducing alpha-amylase levels in diabetic
conditions. Such alpha-amylase inhibitors showed promising alternative treatment in managing
diabetes with reduced adverse effects.

Conclusion:
The current literature concludes that plant-derived alpha-amylase inhibitors present
viable therapeutic avenues for diabetes management by modulating alpha-amylase secretion by
regulating inflammatory, oxidative stress, and apoptotic mechanisms involved in the pathogenesis
of diabetes. Further investigation into their formulations and clinical efficacy may reveal their
more comprehensive diabetes therapeutic significance, emphasizing their potential impact on
glucose regulation and overall health.
Screening Analysis of Predictive Markers for Cytokine Release Syndrome Risk in CAR-T Cell Therapy
Authors: Xu Jiayu , Zhao Chengkui , Wei Zhenyu , Xie Weixin , Cheng Qi , Zhang Min , Han Shuangze , Kang Liqing , Xu Nan , Yu Lei , Feng Weixing 
Published: July 2024

Background:
Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a highly
effective treatment for hematological tumors. However, the associated adverse reaction, Cytokine
Release Syndrome (CRS), poses a significant challenge. While numerous studies have investigated
CRS biomarkers during CAR-T cell therapy, the ability to predict CRS risk prior to treatment initiation
remains a crucial yet underexplored aspect.

Objective:
The primary purpose of this study was to address the issue of limited data, explore an alternative
approach using public data to identify predictive markers for CRS risk assessment from
RNA-Seq in pre-treatment patients data, and comprehend the inducible mechanisms underlying
CRS.

Methods:
We integrated information from two public databases, the FDA Adverse Event Reporting
System (FAERS) for adverse reaction reports of CAR-T cell therapy and the Cancer Genome Atlas
(TCGA) for RNA-Seq data on corresponding hematological tumors. Candidate genes were screened
by correlation analysis between Reported Odds Ratio (ROR) values and RNA-Seq gene expression
levels, and then core factors were identified through stepwise analysis of pathway enrichment, cluster
analysis, and protein interactions.

Results:
Our analysis highlighted the correlation between CRS risk and pre-treatment T cell activation/
proliferation, identifying key genes (IFN-γ, IL1β, IL2, IL6, and IL10) as significant CRS indicators.

Conclusion:
This study offers a unique perspective on predicting CRS risk before CAR-T cell therapy,
circumventing the challenges of scarce clinical data by leveraging analysis of public databases.
It elucidates the crucial role of T cell activation/proliferation dynamics in CRS. The analytical
methods and identified markers provide a reference for the research and clinical application of
CAR-T cell therapy.
Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy
Authors: Ao Imkongyanger , Richa Kikoleho , Lotha Tsenbeni N. , Ao Ketiyala , Rudithongru Lemzila , Nakro Vevosa , Ritse Vimha , Namsa Nima D. , Pankaj Pranay Punj , Sinha Upasana Bora , Jamir Latonglila 
Published: July 2024

Background:
Type 2 Diabetes Mellitus (T2DM) represents a significant and pressing
worldwide health concern, necessitating the quest for enhanced antidiabetic pharmaceuticals.
Guanidine derivatives, notably metformin and buformin, have emerged as pivotal therapeutic
agents for T2DM management.

Aims:
The present study introduces an efficient one-pot synthesis method for the production of
symmetrical guanidine compounds and subsequently, their evaluation as potential T2DM agents.

Methods:
This synthesis involves the reaction of isothiocyanates with secondary amines, employing
an environmentally friendly and recyclable reagent, tetrabutylphosphonium tribromide
(TBPTB). In order to understand the mechanics of ligand-protein interaction, ADME/Toxicity,
and drug-likeliness aspects, in silico studies were incorporated.

Results:
An efficient and easy method for synthesis of guanidine compounds has been devised.
Comprehensive assessment of the biological activity of the synthesized guanidine compounds,
specifically in the context of T2DM, has been rigorously conducted.

Conclusion:
Computational analyses have unveiled their substantial potential as promising antidiabetic
agents. Results highlight the relevance of these compounds in the ongoing pursuit of
novel therapeutic solutions for T2DM.
Correlation Between the Amount of Total Phenolic Contents and Antioxidant Activity of Mediterranean Shrubs: Are Phenols a Good Indicator of the Antioxidant Activity of these Species?
Authors: Chaves Natividad , Navarro Mercedes , Flores Mario , Alias Juan Carlos 
Published: July 2024

Background:
Cells generate reactive oxygen species (ROS), which cause oxidative stress.
Such stress is counteracted by a complex antioxidant system, which includes molecules of the secondary
metabolism of plants, mainly phenols. Several studies attribute the antioxidant activity of a
species to these compounds, although, in other studies, this relationship is not clear.

Objective:
The aim of this study was to determine whether the amount of total phenols is a good indicator
of the antioxidant activity of a species.

Methods:
The present study quantified the total phenols and antioxidant activity measured by DPPH
and ABTS methods of 18 species of Mediterranean scrubs and established the correlation between
these two parameters.

Results:
The obtained results showed that there was a wide variability in the content of phenols
among the analyzed species, with Cistus salviifolius and Nerium oleander presenting the largest and
smallest amount of total phenols, respectively (0.043 and 0.004 gallic acid equivalent (mg/mg dw)).
A cluster analysis differentiated these species into two groups with significantly different amounts of
phenols. The species that constitute Group I presented an average amount of 0.029 gallic acid equivalent
(mg/mg dw), and that of the species of Group II was 0.011±0.003 gallic acid equivalent (mg/mg
dw). The relationship between the antioxidant activity quantified in each species and its content of
total phenols showed a positive and significant correlation; however, when considering the two
groups of species, the significant correlation between these parameters depends on the species group,
the extract concentration used, and the method employed to quantify the antioxidant activity.

Conclusion:
These results indicate that it would not be correct to generalize that there is a significant
correlation between the amount of total phenols and the antioxidant activity. Therefore, total phenol
content cannot be used as a single indicator of the antioxidant activity of a species.
JENIS DAN PERSEBARAN AKTIVITAS PENGGUNA TAMAN HUTAN KOTA PATRIOT BINA BANGSA BEKASI
Authors: Mochamad Ariq Prayogo  , Johannes Parlindungan  , Deni Agus Setyono  
Published: July 2024

Dalam kehidupan sehari-hari, ruang terbuka publik memiliki peran penting sebagai sarana atau lokasi bagi masyarakat untuk melakukan kegiatan yang dapat melepas penat. Taman Hutan Kota Patriot Bina Bangsa Bekasi merupakan salah satu ruang terbuka publik yang terdapat di Kota Bekasi. Taman ini masih memiliki kekurangan seperti kurang lengkapnya dan tidak terawatnya fasilitas yang ada pada taman ini. Hal tersebut dapat memengaruhi para pengguna taman dalam memanfaatkan taman ini. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik dan jenis aktivitas yang dilakukan para pengguna Taman Hutan Kota Patriot Bina Bangsa Bekasi. Penelitian ini dilakukan dengan melakukan pengamatan terhadap perilaku pengunjung dalam memanfaatkan taman menggunakan analisis behavior mapping. Behavior mapping direpresentasikan sebagai sketsa atau diagram yang menunjukkan lokasi di mana orang-orang melakukan berbagai aktivitas. Hasil dari penelitian ini adalah teridentifikasinya karakteristik dan jenis aktivitas pengguna Taman Hutan Kota Patriot Bina Bangsa Bekasi. Aktivitas pengguna yang paling banyak ditemukan berdasarkan hasil temuan pada taman ini adalah aktivitas mengobrol, dengan mayoritas pengguna taman adalah laki-laki, dan kelompok usia pengguna taman terbanyak adalah 26-45 tahun. Sebagian besar aktivitas pengguna taman berpusat pada area plaza taman, di mana area tersebut memiliki ruang yang cukup luas dan dapat dimanfaatkan untuk berbagai jenis aktivitas.
LIVABILITAS TAMAN-TAMAN KOTA DI KOTA BEKASI SEBAGAI RUANG PUBLIK
Authors: Rismania Putri Zelda , Surjono  , Agus Setyono Deni 
Published: July 2024

Livabilitas ruang publik menjadi hal penting untuk mendorong kehidupan sosial kota dan meningkatkan kualitas hidup. Kondisi livabilitas ruang publik yang baik seharusnya dapat memberikan persepsi positif bagi pengunjungnya. Namun, taman sebagai salah satu bentuk dari ruang publik seringkali gagal menyediakan aktivitas yang disukai dan tidak memenuhi kebutuhan penggunanya. Penelitian ini bertujuan untuk mengidentifikasi tingkat livabilitas taman kota di Kota Bekasi yaitu Taman Kota Alun-Alun, Taman Cut Meutia, dan Taman Bantargebang sebagai ruang publik berdasarkan kepuasan pengunjung terhadap atribut livabilitas ruang publik. Metode penelitian yang digunakan adalah analisis skoring untuk memperoleh penilaian kepuasan oleh pengunjung kemudian menormalisasi data dengan metode min-max normalization agar dapat mengadopsi indeks livabilitas oleh AARP. Hasil penelitian menunjukan bahwa Taman Cut Meutia dan Taman Bantargebang berhasil mencapai kondisi livable. Tingkat livabilitas kedua taman berada di kategori above average dengan nilai livabilitas masing-masing sebesar sebesar 66,80 dan 58,90. Kualitas Taman Cut Meutia dan Taman Bantargebang berhasil memberikan pengalaman positif bagi pengunjung. Sementara itu, Taman Kota Alun-Alun belum berhasil mencapai kondisi livable. Tingkat livabilitas taman berada di kategori below average dengan nilai livabilitas sebesar 39,35. Kualitas Taman Kota Alun-Alun belum sepenuhnya berhasil memberikan pengalaman positif bagi pengunjung.
Pendampingan Aspek Perpajakan BUMDES Panca Sedana Sari Desa Bunutin Kecamatan Bangli, Kabupaten Bangli
Authors: Sastri Ida I Dewa Ayu Manik , Pertamawati Ni Putu , Edwindra Riza 
Published: July 2024

Aspek Perpajakan merupakan salah satu momok yang ditakuti dan ingin dihindari dalam pengelolaan sebuah bisnis. Bukan karena ingin menghindar dari kewajibannya tetapi karena keruwetan aturan dan update peraturan perpajakan yang setiap saat menyesuaikan dengan kebutuhan keuangan negara. Tidak semua entitas mengetahui dan siap melaksanakan setiap perubahan peraturan tersebut, mengingat kemampuan yang terbatas baik sari segi pendanaan maupun pengetahuan. Namun perpajakan adalah kewajiban bagi setiap warga negara atas dasar bakti dan balas jasa atas penggunaan fasilitas umum negara. Desa Bunutin merupakan salah satu Desa yang berada di Kecamatan Bangli Kabupaten Bangli. PKM ini menjadi sangat penting untuk dilakukan mengingat adanya beberapa permasalahan yang dihadapi BUMDes Panca Sedana Sari Bunutin yaitu: (1) Sumberdaya manusia, (2) Jenis usaha, (3) Permodalan, (4) Profesionalitas, (5) Dukungan dan kepercayaan masyarakat dan (6) Perencanaan. Melalui BUMDes diharapkan antar Lembaga yang ada di masyarakat saling bersinergi untuk lebih maksimal menciptakan kesejahteraan masyarakat yang setara. Pendirian Bumdes didasarkan pada kebutuhan dan potensi desa, sebagai upaya meningkatkan kesejaheraan masyarakat. Oleh karena itu perlu upaya yang serius untuk menjadikan pengelolaan BUMDes tersebut berjalan secara efektif, efisien, professional dan mandiri. Seperti entitas lainnya BUMDes Panca Sedana Sari juga memiliki kewajiban perpajakan yang harus dilaporkan setiap bulan atas SPT masanya dan setiap tahun atas SPT tahunannya. Namun keterbatasan sumberdaya yang dimiliki menyebabkan BUMDes tidak dapat melakukan update pengetahuan dan aturan perpajakan sehingga perlu dilakukan pengabdian ini pada aspek perpajakan BUMDes Panca Sedana Sari. Hasil Pengabdian dapat dilihat dari terlapornya SPT Tahunan BUMDes yang telah mengikuti pendampingan aspek perpajakan, sehingga dapat diminimalisir denda dan kesalahan akibat ketidaktahuan pengurus.
The Risk of Acute Kidney Injury in Patients Undergoing Coronary Angiography
Authors: Alhozali Hanadi , Qutub Mohammed , Alharbi Nada Mohammed , Awlia Ghram W , Alraddadi Meiral I , Algarni Areej A , Almutiry Renad A 
Published: July 2024

Objective: This study was conducted to estimate the risk of contrast-induced AKI (CI-AKI), among Saudi patients who underwent CA or PCI at a tertiary care hospital, to understand the incidence and the underlying contributory factors of CI-AKI.
Methods: We conducted a retrospective review of patients who underwent CA or PCI from 1st January 2018 to 31st December 2020, at the King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
The exclusion criteria comprised age <18 years, preexisting chronic kidney disease (stage III–V), prior renal transplantation and records with missing key clinical information. Occurrence of AKI was defined using the “Kidney Disease: Improving Global Outcomes” (KDIGO) consensus definition. Statistical Package for the Social Sciences (SPSS) software, version 21 was used for statistical analysis. The prevalence is presented as a percentage with a 95% confidence level. P-value <0.05 was considered statistically significant.
Results: We reviewed 825 patient files, of which 754 met the inclusion criteria. According to the KDIGO classification, the mean overall incidence of Stage I CI-AKI in our study cohort was 8.1%, while no patients developed stage II and III AKI. The incidence of CI-AKI was 6.4% in patients <55 years of age (n=264) and 7.8% in the age group of 55-70 years. A significantly higher incidence of 13.3% was seen in patients above the age of 70 years. The increase in the incidence of CI-AKI in patients above 70 years, versus their younger counterparts was statistically significant (P = 0.075).
Conclusions: Based on the results of this study and past literature, the overall incidence of CI-AKI is around ≤10%, among patients undergoing CA or PCI; which seems lower than the high risk perception among cardiologists. While CI-AKI is a known post-procedural complication of CA or PCI, the apprehension of the potential risk of CI-AKI, should not defer or obstruct the decision to perform CA or PCI for deserving and needy candidates. Exercising caution among high-risk patients, individual risk-benefit assessment and employing well-established pre and peri-procedural prevention protocols can significantly mitigate the risk of CI-AKI; even among high-risk patients.
Penggunaan Model Problem Based Learning Berbantuan Video Powtoon Untuk Meningkatkan Kemampuan Berpikir Kritis Siswa Kelas III Sekolah Dasar
Authors: Nina Vania  , Wahyu Hidayat  , Trisna Nugraha  
Published: July 2024

Keterampilan berpikir tingkat tinggi seperti berpikir kritis dapat mendukung proses berpikir kritis siswa. Namun pada kenyataannya banyak siswa yang masih kekurangan kemampuan berpikir kritis karena mungkin sebagian guru tidak menyertakan kemampuan tersebut proses belajar mengajar. Sehingga menyebabkan siswa belum mampu menyampaikan pendapatnya. Melalui penggunaan video powtoon dan PBL tujuan penelitian ini adalah untuk memberikan peningkatan kemampuan dalam menganalisis, mengevaluasi serta berpikir secara kritis dalam konsep keliling dan luas bangun datar yang ada di kelas III SD. Desain Sequential eksplanatory design adalah salah satu desain yang digunakan dalam proses penelitian ini. Siswa kelas III SD menjadi salah satu subjek penelitan yang ada di SDN Giriraharja. Penelitian ini melalui dua tahapan, langkah pertama adalah pengumpulan serta analisis data kuantitatif tekniknya dengan memberikan tes mengenai kemampuan berpikir kritis. Pada langkah kedua, data kualitatif dikumpulkan serta dianalisis menggunakan teknik wawancara, angket respon dan formulir observasi. Penelitian ini menunjukan bahwa hasil penggunaaan model PBL berbantuan video

powtoon secara signifikan terdapat peningkatan berpikir kritis. Ini terbukti dari nilai yang diraih oleh para siswa pada saat pretest rata-rata 63 kemudian berubah dengan nilai postest rata-rata sebesar 84 dengan hasil uji cohen`s effect size sebesar 1,826. Dalam tinjauan kualitatif yang melibatkan analisis lebih lanjut, ditemukan bahwa dengan menggunakan model PBL berbantuan video powtoon ini berperan dalam mengaktifkan suasana kegiatan belajar mengajar menjadi aktif serta interaktif serta siswa dapat mengidentifikasi masalah dan merumuskan jawaban dari permasalahan yang diberikan terbukti dengan tingginya antusias dan repon siswa. Dengan hasil tersebut diharapkan penelitian ini mampu berkontribusi dalam pengembangan inovasi pembelajaran berpusat pada siswa serta pengembangan motion grapich.
A Comparative Analysis of Modern Object Detection Algorithms: YOLO vs. SSD vs. Faster R-CNN
Authors: Aboyomi Dalmar Dakari , Daniel Cleo 
Published: July 2024

In recent years, object detection has become a crucial component in various computer vision applications, including autonomous driving, surveillance, and image recognition. This study provides a comprehensive comparative analysis of three prominent object detection algorithms: You Only Look Once (YOLO), Single Shot MultiBox Detector (SSD), and Faster Region-Based Convolutional Neural Networks (Faster R-CNN). The background of this research lies in the growing need for efficient and accurate object detection methods that can operate in real-time. YOLO is known for its speed, SSD for its balance between speed and accuracy, and Faster R-CNN for its high detection accuracy, albeit at a slower pace. The methodology involves implementing these algorithms on a standardized dataset and evaluating their performance based on various metrics, including detection accuracy, processing speed, and computational resource requirements. Each algorithm is tested under similar conditions to ensure a fair comparison. The results indicate that while YOLO excels in real-time applications due to its high speed, SSD offers a middle ground with respectable accuracy and speed, making it suitable for applications requiring a balance of both. Faster R-CNN demonstrates superior accuracy, making it ideal for scenarios where detection precision is paramount, despite its slower performance. This comparative analysis highlights the strengths and weaknesses of each algorithm, providing valuable insights for researchers and practitioners in selecting the appropriate object detection method for their specific needs.