bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversity of Rhizophydiales (Chytridiomycota) in Thailand: unveiling the hidden gems of the Kingdom
Authors: Hurdeal Vedprakash G. , Longcore Joyce E. , Jones E. B. Gareth , Hyde Kevin D. , Gentekaki Eleni 
Published: June 2024

AbstractChytrids, often overshadowed by their other fungal counterparts, take center stage as we unravel the mysteries surrounding new species within Rhizophydiales and explore their unique characteristics. In the broader spectrum of chytrids, their significance lies not only in their roles as decomposers but also as key players in nutrient cycling within aquatic ecosystems as parasites and saprobes. Baited soil and aquatic samples collected from various provinces of Thailand, yielded new species of the Rhizophydiales (Chytridiomycota), some of which expanded previously single species genera. Our investigation incorporated a combination of morphological and phylogenetic approaches, enabling us to identify these isolates as distinct taxa. The novel isolates possess distinguishing features, such as variations in size and shape of the sporangium and zoospores, that somewhat differentiate them from described taxa. To confirm the novelty of the species, we employed robust phylogenetic analyses using maximum likelihood and bayesian methods. The results provided strong support for the presence of eight distinct lineages within the Rhizophydiales, representing our newly discovered species. Furthermore, we employed Poisson Tree Processes to infer putative species boundaries and supplement evidence for the establishment of our new Rhizophydiales species. By meticulously exploring their morphological characteristics and genetic makeup, we expand the known catalogue of fungal diversity by describing Alphamyces thailandicus, Angulomyces ubonensis, Gorgonomyces aquaticus, G. chiangraiensis, G. limnicus, Pateramyces pingflumenensis, Terramyces aquatica, and T. flumenensis and also provide valuable insights into the intricacies of this order. This newfound knowledge not only enriches our understanding of Rhizophydiales but also contributes significantly to the broader field of mycology, addressing a critical gap in the documentation of fungal species. The identification and characterization of these eight novel species mark a noteworthy stride towards a more comprehensive comprehension of fungal ecosystems and their vital role.
Novel TRPV6 variant linked with transient neonatal hyperparathyroidism
Authors: Kumar Chanchal , Vani Sarada , Deshmukh Namita Neelkanth , Omkaram Sujith , Pothala Rajeev , Bathina Sushma Poornima , Dodda Deepika 
Published: June 2024

Abstract
Background
Hereditary transient neonatal hyperparathyroidism (TNHP) is a rare autosomal-recessive condition caused by variants in TRPV6 gene which encodes for a transient maternal–fetal calcium transport channel. This is characterized by interference with placental maternal–fetal calcium transport causing fetal calcium deficiency. It primarily manifests as defective bone mineralization, narrow and bell-shaped thorax, bone fractures and short bones at birth. The current study aimed to describe a novel TRPV6 variant linked with TNHP in an Indian family and the review of literature.

Case presentation
The proband is a term female neonate with fetal growth restriction born to a third-degree consanguineous couple. She was noted to have diffuse defective bone mineralization, narrow and bell-shaped thoracic cavity, short bones and curved ribs without any bone fractures. The first pregnancy was affected with similar features in the fetus and had been terminated. Parental whole-exome sequencing suggested heterozygous missense variant in exon 12 of the TRPV6 gene (c.1585G > A, p.Asp529Asn) in both the parents. The proband required non-invasive respiratory support for ten days in neonatal intensive care unit. She had low calcium and high parathyroid hormone (PTH) and alkaline phosphatase (ALP) levels. She received calcium, phosphorus and vitamin D supplements for three months leading to normalization of serum PTH and ALP levels. Whole-exome sequencing of the proband suggested a homozygous missense variant in exon 12 of the TRPV6 gene (p.Asp529Asn; ENST00000359396.9) that results in the amino acid substitution of asparagine for aspartic acid at codon 529. To the best of author’s knowledge, this is the twelfth case of TNHP reported in literature. The novel variant of TRPV6 gene present in this family has not been reported earlier.

Conclusion
Our finding broadens the genotypic spectrum of TNHP.
Prevalence and factors causing test anxiety among medical students
Authors: Almutairi Atheer G. , Baabbad Nuran Mazen , Alhumaidan Almaha Abdullah , Alshahrani Aljawharah Mohammed , Alabdulkarim Alanoud Ibrahim , Alsughier Naif 
Published: June 2024

Abstract
Background
Test anxiety (TA) is described as a set of psychological and behavioral responses that occur when a person is concerned about the possibility of unfavorable results or failing on an exam. Based on multiple studies, medical education is known for its rigorous curricula, continuous high academic demands, frequent assessments, practical instruction, and mentorship, all of which contribute to a stressful atmosphere that results in elevated rates of depression, anxiety during exams, subpar academic achievement, and a higher number of medical student dropouts. This study aimed to measure the prevalence of test anxiety and predisposing factors among students at Unaizah College of Medicine.

Results
Our study revealed that 45.4% of responders reported having low anxiety, while 33.2% of them reported having moderate anxiety. A lower but statistically significant percentage (21.5%) expressed high levels of anxiety. Regarding the factors contributing to exam anxiety in medical students such as social support, it was found that the students with poor social support exhibited significant odds of severe test anxiety. Remarkably, there was a decreased likelihood of experiencing severe anxiety when studying all the night before the exam.

Conclusion
Research results have the potential to impact institutional policies concerning medical students’ well-being. Colleges can create supportive environments that address the factors causing test anxiety and promote mental health and academic success.
Phase II Study of Ulixertinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Alterations: APEC1621J of the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial
Authors: Vo Kieuhoa T. , Sabnis Amit J. , Williams P. Mickey , Roy-Chowdhuri Sinchita , Patton David R. , Coffey Brent , Reid Joel M. , Piao Jin , Saguilig Lauren , Alonzo Todd A. , Berg Stacey L. , Jaju Alok , Fox Elizabeth , Weigel Brenda J. , Hawkins Douglas S. , Mooney Margaret M. , Takebe Naoko , Tricoli James V. , Janeway Katherine A. , Seibel Nita L. , Parsons D. Williams 
Published: June 2024

PURPOSE The National Cancer Institute-Children's Oncology Group (NCI-COG) Pediatric MATCH trial assigns patients age 1-21 years with refractory malignancies to phase II treatment arms of molecularly targeted therapies on the basis of genetic alterations detected in their tumor. Patients with activating alterations in the mitogen-activated protein kinase pathway were treated with ulixertinib, an extracellular signal-regulated kinase (ERK)1/2 inhibitor. METHODS As there were no previous pediatric data, ulixertinib was initially tested in a dose escalation cohort to establish the recommended phase II dose (RP2D) before proceeding to the phase II cohort. Ulixertinib was administered at 260 mg/m2/dose orally twice a day (dose level 1 [DL1], n = 15) or 350 mg/m2/dose orally twice a day (DL2, n = 5). The primary end point was objective response rate; secondary end points included safety/tolerability and progression-free survival (PFS). RESULTS Twenty patients (median 12 years; range, 5-20) were treated, all evaluable for response. CNS tumors comprised 55% (11/20) of diagnoses, with high-grade glioma and low-grade glioma most common (n = 5 each). All CNS tumors except one harbored BRAF fusions or V600E mutations. Rhabdomyosarcoma (n = 5) was the most frequent non-CNS diagnosis. DL1 was declared the RP2D in the dose escalation cohort after dose-limiting toxicities in Cycle 1 occurred in 1/6 patients at DL1 and 2/5 patients at DL2, including fatigue, anorexia, rash, nausea, vomiting, diarrhea, dehydration, hypoalbuminemia, and hypernatremia. No objective responses were observed. Six-month PFS was 37% (95% CI, 17 to 58). Three patients with BRAF-altered CNS tumors achieved stable disease >6 months. CONCLUSION Ulixertinib, a novel targeted agent with no previous pediatric data, was successfully evaluated in a national precision medicine basket trial. The pediatric RP2D of ulixertinib is 260 mg/m2/dose orally twice a day. Limited single-agent efficacy was observed in a biomarker-selected cohort of refractory pediatric tumors.
Determinants of Energy Intensity in Emerging Economies: A Comprehensive Review of the Last Three Decades
Authors: Haider Zaidi Syed Anees , Dessoulavy-Śliwiński Bartłomiej , Ashraf Rana Umair , ul Haq Muhammad Ahtisham 
Published: June 2024

ObjectivesThis review article delves into the determinants of energy intensity in emerging economies, spanning the past 30 years of research accessed from Web of Science. The review employ data visualization techniques to present a bird's-eye view of the research landscape, showcasing the geographical distribution of studies, prominent authors, and key journals in the field.Material and methodsThis bibliometric study utilized the March 2023 edition of the Web of Science (WoS) Core Collection database for its papers. The literature review covers the years 1993 to 2023 and includes all studies on the subject of energy intensity in the pursuit of emerging economic goals. Journal articles are isolated from the other document types using an additional filter. The WoS Core Collection database had a total of 3,918 articles.ResultsThrough a systematic assessment of methodological approaches, we evaluate the robustness of the existing literature, pinpointing areas where methodological improvements and novel data sources can enhance future research. It offers valuable insights for policymakers, researchers, and practitioners striving to develop effective strategies for reducing energy intensity and promoting green growth.ConclusionsIn conclusion, emerging economies' energy intensity levels are shaped by a complex interplay of determinants that were highlighted by the analysis of factors influencing energy intensity on economic growth. In order to achieve a more sustainable and resilient energy future, emerging economies must first address these determinants through research, collaboration, and policy actions.
Climate risk in banks – the case of Polish banking sector
Authors: Nocoń Aleksandra 
Published: June 2024

ObjectivesThe issues of environmental protection, including stopping the degrading climate change, are currently a subject of particular interest of the scientific community, policymakers, practitioners, but also all people around the world. Banking institutions, as a giver of capital, play a special role in financing climate protection activities. On the other hand, they are particularly exposed to climate risk. The main purpose of the paper is climate risk exegesis and to analyze the degree of climate risk inclusion in the bank risk management process in the case of the Polish banking sector. The conducted empirical research verified the research hypothesis stating that the Polish banking sector is becoming more and more oriented towards the climate risk among the bank risk management systems.Material and methodsThe following research methods were used in the paper: survey questionnaire method, case study analysis, observation method and synthesis method. The research procedure included two stages of questionnaire research, followed by the analysis and evaluation of the obtained results.ResultsIt has been shown that the Polish banking sector defines its climate goals and is increasingly sensitive to the climate risk management, including them in its risk management systems. It also assesses exposure to climate risk in terms of physical and transitional risk.ConclusionsThe research and results presented in this study are important in building political awareness as well as public, social and economic activities in the field of counteracting climate threats. However, banks’ awareness is very important for financing projects that reduce degrading impact on climate.
The procedure of naming streets and squares
in the practice of functioning municipalities in Poland. Selected issues
Authors: Lewandowski Krzysztof Henryk 
Published: June 2024

Cel pracyCelem pracy jest omówienie wybranych problemów dotyczących czynności administracyjnoprawnej nadawania nazw ulic i placów w praktyce funkcjonowania podstawowych jednostek samorządu terytorialnego. W pracy omówiono podstawowe pojęcia zarówno w ujęciu ustawowym, dorobku doktryny i judykatury. Omówiono podstawy prawne nadawania nazw ulic i placów, stosowane przez jest formy procedury w tym zakresie.Materiał i metodyDo opracowania publikacji posłużyły treści aktów prawnych, publikacji naukowych oraz tez orzeczeń sądownictwa administracyjnego. Wykorzystano głównie metodę prawno-porównawczą.WynikiW wyniku przeprowadzonej kwerendy ustalono, że materia stanowiące przedmiot opracowania jawi się niejednorodnie, pełna jest pojęć nieostrych. Stosowane procedury nadawania nazw ulic i placów przez gminy nie są jednorodne i często organizowane w rożny sposób.WnioskiZebrane wyniki pozwalają postawić wniosek o podjęcie prac o dokonanie pełnej i jasnej regulacji zagadnienia przez ustawodawcę w przyszłości, gdyż pozostawienie tej materii w dużej swobodzie organizacyjno-prawnej, przy zwiększającej się świadomości prawnej wraz ze wzrostem społecznej roszczeniowości, będzie generować dalsze problemy w przyszłości. Proponowane zmiany powinny przewidywać głównie wypracowanie delegacji ustawowej dla rady gminy do nadawania nazw ulic i placów nie tylko w przepisach ustrojowych, ale także w prawie materialnym. Ponadto winny nakładać na radę gminy obowiązek uchwalenia przez organ wykonawczy podstawowej jednostki samorządu terytorialnego zasad i trybu nadawania nazw ulic i placów, uwzględniając daleko idącą pluralizację społeczną w tym zakresie
Prognostic value of systemic immune-inflammation index/albumin ratio for immunotherapy-treated patients receiving opioids
Authors: Yan Lei , Kang Pan , Cao Chengsong , Jinhui Bu , Yong Liu 
Published: June 2024

Objective
This study evaluated the effect of the systemic immune-inflammation index/albumin ratio (SII/ALB) on the prognosis of immunotherapy-treated patients receiving opioids.

Methods
A retrospective analysis was conducted of 185 immunotherapy-treated patients who received opioids at Xuzhou Central Hospital from 01/09/2021 to 01/09/2023. The results of related clinical data were collected during the week before the cancer patients received immunotherapy. The SII/ALB cut-off value was determined, and the relationship between the SII/ALB and clinical pathological parameters was analyzed using the chi-square test. The effect of the SII/ALB on progression-free survival (PFS) was examined using Kaplan-Meier curves and the Cox proportional hazard model.

Result
The SII/ALB cut-off value was 20.86, and patients were divided into low (SII/ALB ≤ 20.86) and high (SII/ALB > 20.86) SII/ALB groups. Adverse reactions (hazard ratio [HR] = 0.108; 95% confidence interval [CI]: 0.061–0.192, P < 0.001) and the SII/ALB (HR = 0.093; 95% CI: 0.057–0.151, P < 0.001) were independent prognostic factors for PFS. Compared with the high SII/ALB group, the low SII/ALB group had longer PFS after opioid treatment (12.2 vs. 5.2 months, P < 0.001).

Conclusion
The SII/ALB is a potentially important prognostic parameter in immunotherapy-treated patients receiving opioids.
Healing responses at the angle after micro-invasive glaucoma surgery-an AS-OCT study
Authors: Rao Aparna , Mukherjee Sujoy 
Published: June 2024

Purpose
To evaluate structural alterations and healing responses in the trabecular meshwork region with optical coherence tomography (AS-OCT) following after gonioscopy assisted transluminal trabeculotomy (GATT) and microincisional trabeculectomy (MIT).

Methods
73 eyes of 67 patients (M:F = 45:22) with ≥6 months of follow-up after MIT (n = 41) or GATT (n = 32) with or without combined cataract surgery were included for this prospective study. The angle as seen on AS-OCT at 1, 3, 6 months after surgery were evaluated for structural alterations like peripheral anterior synechiae (PAS), hyphema, and hyperreflective scarring responses. The scarring was graded according to the linear extent measured from the centre of the trabecular meshwork (TM) gutter to the sclera/cornea as mild (<250μ), moderate (250–500μ), and severe(˃500μ), while the pattern of scarring was graded as open saucer/gutter, closed gutter, and trench pattern. The association of the need for medication or surgical outcome and clinical variables and AS-OCT parameters including the pattern and severity of scarring were analysed using multivariate regression.

Results
All eyes achieved significant reduction of IOP and number of medications with a final IOP of 15±3.2mm Hg at a mean follow-up of 8±32. months. While mild scarring was seen more common in MIT, severe scarring was seen in >65% of GATT eyes compared to 31% of MIT eye, p<0.001. An open saucer was equally seen in MIT and GATT while the trench pattern was more commonly seen in GATT eyes (>50%). Severe scarring in a trench pattern seemed to predict the need for medications for IOP control, though they independently did not seem to influence the final IOP or surgical outcome.

Conclusion
A severe form of scarring in a trench pattern on AS-OCT predicted the need for glaucoma medications after MIGS surgery. Regular monitoring of the scarring responses by AS-OCT and clinical examination are necessary to identify those at need for medications after MIGS.
Effect of forward and backward sloped support surfaces on postural equilibrium and ankle muscles activity
Authors: Atsawakaewmongkhon Siripatra , Couillandre Annabelle , Hamaoui Alain 
Published: June 2024

Introduction
Although sloped surfaces are common in daily living, most studies of body balance are carried out on flat surfaces, and few data are available for sloping angles below 14°.

Objectives
The purpose of this study was to explore the effect of forward and backward sloping surfaces at 7° and 15° on postural equilibrium and the activity of flexor/extensor ankle muscles.

Methods
Fifteen healthy subjects (8 males and 7 females) (27.67 ± 3.9 years) underwent a posturographic examination associated with a surface electromyogram (EMG) of tibialis anterior (TA), soleus (Sol) and gastrocnemius medialis (GasM) under five conditions of support inclination: 0° (H0), backward inclination at 7° and 15° (DF7 and DF15), forward inclination at 7° and 15° (PF7 and PF15).

Results
Results showed that the center of pressure (CP) was shifted according to the surface slope, with a forward move in PF7 (p <0.001) and PF15 (p <0.001) and a backward move in DF7 (p <0.01) and in DF15 (p <0.001). The mean displacement of the CP along the anterior-posterior axis (Xm) was increased in DF15 (p <0.01) relative to the H0 condition but reduced in PF7 (p <0.01). The normalized EMG revealed higher values when the muscles were in a shortened position (PF7 for Sol, p <0.05; PF15 for GasM, p <0.01; DF15 for TA, p<0.01) and lower values of GasM and Sol when lengthened (DF15, p <0.05).

Conclusion
Our findings indicate that standing on a backward sloped surface impairs body balance, while low-angle forward sloped surfaces might improve postural stability. Muscular activity variations of the ankle flexors/extensors, which are stretched or shortened, also seem to be related to the length-tension relationship of skeletal muscles.
Utilization of expert opinion in infectious diseases clinical guidelines—A meta-epidemiological study
Authors: Nagavci Blin , Schwingshackl Lukas , Martin-Loeches Ignacio , Lakatos Botond 
Published: June 2024

Introduction
Expert opinion is widely used in clinical guidelines. No research has ever been conducted investigating the use of expert opinion in international infectious disease guidelines. This study aimed to create an analytical map by describing the prevalence and utilization of expert opinion in infectious disease guidelines and analyzing the methodological aspects of these guidelines.

Methods
In this meta-epidemiological study, systematic searches in PubMed and Trip Medical Database were performed to identify clinical guidelines on infectious diseases, published between January 2018 and May 2023 in English, by international organizations. Data extracted included guideline characteristics, expert opinion utilization, and methodological details. Prevalence and rationale of expert opinion use were analyzed descriptively. Methodological differences between groups were analyzed with Chi-square and Mann-Whitney U Test.

Results
The analysis covered 66 guidelines with 2296 recommendations, published/endorsed by 136 organizations. Most guidelines (79%) used systematic literature searches, 42% provided search strategies, and 38% presented screening flow diagrams and conducted risk of bias assessments. 48.5% of the guidelines allowed expert opinion, most of which included expert opinion as part of the evidence hierarchy within the grading system. Guidelines allowing expert opinion, compared to those which do not, issued more recommendations per guideline (48.82 vs.19.13, p<0.001), and reported fewer screening flow diagrams (25% vs. 65%, p = 0.002), and less risk of bias assessments (19% vs.78%, p<0.001).

Conclusions
Expert opinion is utilized in half of assessed guidelines, often integrated into the evidence hierarchy within the grading system. Its utilization varies considerably in methodology, form, and terminology between guidelines. These findings highlight a pressing need for additional research and guidance, to improve and advance the standardization of infectious disease guidelines.