bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional Industrial Structure Upgrading, Labor Heterogeneity and Cost of Living in China
Authors: Wang Weijia 
Published: July 2024

Abstract

This paper applies Chinese provincial panel data from 2001-2015 to conduct an empirical study to investigate the differential impact of China's regional industrial structure upgrading on labor force heterogeneity by constructing a task-theoretic model, and the results show that regional industrial structure upgrading exhibits a significant growth trend in the demand for senior labor force, whereas the demand for intermediate and junior labor force demonstrates a certain negative impact. In order to further analyze the influence path, and taking into account the regional heterogeneity in China, especially in the eastern coastal region, the cost of living variable is further introduced as a cross-multiplier term for the analysis due to the higher cost of living in the region, and the results show that the increase in the cost of living reduces the overall demand for the labor force, which not only is not conducive to the optimization and upgrading of the local industrial structure, but also impedes the sustained development of the economy. Based on this, this study puts forward corresponding policy recommendations: by upgrading the education and skill levels of the primary labor force, the demand for labor can be effectively increased, thus solving the structural contradiction of employment in China; at the same time, by lowering the cost of living and providing subsidies for renting or purchasing houses, more talents can be attracted to provide solid human resources support for the upgrading of the regional industrial structure.
An Analysis of Assessment Techniques and Learning Outcomes in Grade 10 History Curricular Materials
Authors: Lemu Getachew , Melese Wudu , Debu Deressa 
Published: July 2024

Abstract

The current Ethiopian Grade Ten Histor Textbook has been scrutinized through the lens of Bloom's Taxonomy to evaluate its learning outcomes and assessment activities. The study indicates that the majority of the learning outcomes and assessment activities in the textbook primarily focus on factual knowledge and conceptual understanding, emphasizing the retention of historical terms and events. The results also reveal that the history textbook learning outcome statements predominantly emphasize lower-order thinking skills. Specifically, 53.19% of the content focused on remembering, understanding, and applying, while only 46.78% of the statements centered on higher-order thinking skills, such as analyzing, evaluating, and creating. To enrich history teaching, the study recommends integrating disciplinary strategies and historian methods to cultivate critical thinking skills, enabling students to make informed judgments and navigate the complexities of the modern world. To achieve this goal, Ethiopian history textbook writers should emphasize the concept of historical thinking, and research evidence to improve educational practice, which is a set of cognitive processes that enables individuals to analyze, evaluate, and contextualize historical information.
Enhancing Research on Academicians in Cambodian Higher Education: A Policy Perspective
Authors: Sam Rany , Tieng Morin , Yoeng Hak , Chiv Sarith , Serey Mardy , Sam Sopheak 
Published: July 2024

Abstract

Cambodia's higher education institutions (HEIs) face a number of challenges. Academics require increased access to resources and funding, as well as restrictions on academic freedom and significant language and cultural barriers. The purpose of this chapter is to identify and analyze the individual factors influencing academicians' research productivity in Cambodian higher education institutions, to examine and evaluate the impact of institutional factors on research productivity, to investigate and assess the external factors affecting research productivity, and to develop strategies to mitigate negative impacts while increasing positive influences. This study employs a qualitative approach, with insights gained through interviews and policy analysis. This comprehensive approach provides a thorough understanding of Cambodia's current academic research landscape, highlighting areas that require policy-driven solutions. The findings emphasize the critical need for policies that are tailored to the Cambodian academic context. There is a clear need to foster stronger domestic and international research collaborations as well as mechanisms that encourage long-term research development. The study proposes a set of focused policy recommendations designed to overcome these challenges and enhance the research productivity of Cambodian HEIs. These policies, if implemented, have the potential to significantly improve the research landscape in Cambodian HEIs, fostering a sense of hope and optimism among the academic community.
Geographical Difference in Patient Satisfaction with Healthcare Services for Older Adults in Vietnam
Authors: Tuyet Nguyen Anh , Dung Le Duc , Anh Nguyen Tuan 
Published: July 2024

Abstract

As economic growth and a rapidly aging population drive substantial demand for healthcare services in Vietnam, it is salient that more attention be paid to assessing patient satisfaction among older adults. Specifically, the study aims to shed light on the critical aspect of patient satisfaction among older adults, which has not been extensively explored in previous research conducted within the country. By utilizing national data from the Vietnam Aging Survey, our analysis showed that approximately 83.2% of older patients were satisfied with healthcare services. Notably, there were significant differences in healthcare service satisfaction between the Northern and Southern regions. Furthermore, healthcare satisfaction varied based on educational levels and social insurance holding status. While insurance coverage and socio-demographic factors played important roles in narrowing the gap between the Northern and Southern regions, the type of facility widened the regional difference in healthcare satisfaction. In light of these results, our study underscores the importance of national policies prioritizing enhancing social insurance mechanisms and improving the quality of healthcare services at the district level in rural areas. These measures are crucial for achieving geographic equity in patient satisfaction with healthcare services in Vietnam.
Copper (II) and cobalt (II) bis(hexafluoroacetylacetonate) coordination complexes with N-styrylbenzimidazole
Authors: Chernigova P. O. , Sinegovskaya L. M. , Parshina L. N. , Sterkhova I. V. , Smirnov V. I. 
Published: July 2024

The study considers metal complexes based on N-styrylbenzimidazole as compounds having significant pharmacological properties The work is aimed at examining the crystal structure and electronic structure of transition metal bis(hexafluoroacetylacetonate) complexes (copper (II) (complex A) and cobalt (II) (complex B)) with N-styrylbenzimidazole using X-ray diffraction analysis and ultraviolet spectroscopy. The X-ray diffraction analysis was used to prove bipyramidal coordination in copper (II) and cobalt (II) bis(hexafluoroacetylacetonate) complexes with N-styrylbenzimidazole. The atoms of copper (II) and cobalt (II) in the complexes exhibit an unusual for β-diketonate complexes distorted square-planar coordination, while the chelate cycles in M(hfacac)2L are characterized by anomalously large kink angles. Thus, for the copper (II) bis(hexafluoroacetylacetonate) complex, the kink angle of the O3∙∙∙O4 interaction for the equatorially positioned ligand is 29.47°, while for the axially positioned ligand, the kink angle of the O1∙∙∙O2 interaction is 19.13°. For the cobalt (II) bis(hexafluoroacetylacetonate) complex, these angles are 22.10 and 19.50°, respectively. Electron spectroscopy was used to examine the electronic structure of the specified complexes. The following types of electronic transitions were identified: π→π*-transitions primarily localized on ligands, as well as transitions caused by electron transfer from the p-orbital of the hetero nitrogen atom of the styrylbenzimidazole cycle to the d-orbital of metal ions, and n→π transition localized on the imidazole ring. For each of the complexes, d-d* transitions between the molecular orbitals of the corresponding metal ion were localized in the long wavelength part of the spectrum.
Identification of iodothyronines in plant tissues
Authors: Garipova M. I. , Fedyaev V. V. , Datsko O. I. 
Published: July 2024

It has become widespread knowledge that many signaling molecules are common to organisms of different groups. This is likely to be valid for such important metabolism regulators as iodothyronines. A number of studies have confirmed the presence of thyroid hormone activity in compounds of plant origin. However, these studies do not explain whether the compounds under consideration are iodine derivatives of thyronine, similar to animal and human thyroid hormones, or whether they are mimetics of thyroid hormones. In this work, we aim to verify the presence of iodothyronine analogs with different degrees of iodization in plant tissues. We also aim to determine iodine concentrations in plant tissue lysates and to compare them with the theoretically calculated values in order to test the assumption about the identity of their structure to human thyroid hormones. It was shown that tetraiodothyronine (T4) and triiodothyronine (T3) analogs are simultaneously present in potato tubers and wheat leaves. In potato tubers at dormancy, the concentration of T4 was 118 ± 16 nmol/L (n = 15), while the concentration of T3 in the same samples was 4.01 ± 0.96 nmol/L. T4 and T3 concentrations in wheat leaf lysates were 60.24 ± 79 and 6.76 nmol/L (n = 15), respectively. According to the results of inductively coupled plasma mass spectrometry, the studied samples contain iodine in the amounts consistent with the assumption about the presence of tetraiodinated tyronine derivatives.
Density and stability of oil-in-water emulsions
Authors: Matienko O. I. , Filatova E. G. , Chebunin V. A. 
Published: July 2024

The stability of oil-in-water emulsions is determined by the physicochemical properties of oil, as well as the composition of emulsified water. The present work aims to study the effect of concentration and temperature on the density and stability of oil-in-water emulsions. Classical oil emulsions of the first type were prepared with aqueous CaCl2 solution and oil from the Yarakta field. The ratios of the hydrocarbon component to the aqueous phase were as follows, vol %: 5:92, 10:87, 15:82, 20:77, 25:72, 30:67, and 35:62 with the addition of emulsifier. The density of emulsions was studied using the pycnometer method, with a measurement error of up to ±0.01 kg/m3. The method consists in accurately determining the mass of the test solution and distilled water, which occupy a known volume (50 cm3) in the pycnometer, and using a high-precision analytical scale. The obtained regression equations provide a means to calculate the densities of oil-in-water emulsions within the studied temperature (20–60 °С) and oil concentration (5–35 vol %) ranges. The derived empirical equations can be used in practice. It is shown that with increasing oil concentration and temperature, the density of emulsions decreases. The stabilizing ability of oil-in-water emulsions was evaluated in terms of luminous transmittance: the luminous transmittance value served as a stability criterion of emulsions in water. It was experimentally confirmed that the stabilizing ability of emulsions decreases with increasing temperature. The obtained results can be used in the study of regularities defining the direction and extent of chemical transformations and stabilization of oil-in-water emulsions, as well as in the solution of practical issues related to their destruction.
Relationship Between Temperature and Humidity on Rainfall
Authors: Purnama Mohammad Dian , Mustafidah Mutia Eva 
Published: July 2024

Indonesia is one of the tropical countries in the world that has two seasons, the dry season and the rainy season. One of the biggest challenges in tropical countries is flooding caused by heavy rainfall. Not only does it cause flooding, rainfall also affects several sectors especially agriculture. Areas that have a lot of rain-fed agricultural land, especially rice fields, depend on rainfall because it determines crop yields. This study uses data from 12 sub-districts in Mojokerto district where agricultural activities are one of the pillars of the economy in the region. There are various factors associated with rainfall such as temperature and humidity. The data used is the year 2022 using multiple linear regression. Based on the results of the study, both predictor variables have a strong and positive relationship with rainfall with a correlation coefficient of 0.760007. With a significance level of 5% or 0.05, in the partial test, only the humidity variable has a significant effect on the amount of rainfall. While in the simultaneous test, both variables have a significant effect. These factors together have a coefficient of determination of 0.57761 or the contribution of the influence of the two predictor variables of 57.761% while the remaining 42.239% by other variables.
Study on Pharmacological Activities and Mechanisms of the Essential Oil of the Flowers of Hemerocallis citrina Baroni (EOFHCB) in the Treatment
of Anxiety Disorders by GC-MS, Network Pharmacology, and Molecular Docking
Authors: Lu Tao , Liu Ziyi , Zhao Huaxiang , Zhou Xuan , Wang Qiong , Jiao Xiaoning , Lu Zhen 
Published: July 2024

Background:
Hemerocallis citrina Baroni (Huanghuacai), a plant of the genus Hemerocallis
in the family Asphodelaceae, is widely planted in China. Based on our survey results,
the chemical compounds in the essential oil of the flowers of Hemerocallis citrina Baroni
(EOFHCB) and relevant pharmacological activities have never been studied systematically.

Objective:
To preliminarily decipher the pharmacological activities and mechanisms of EOFHCB
in the treatment of anxiety disorders by GC-MS, Network Pharmacology, and Molecular docking.

Methods:
EOFHCB compositions were identified using GC-MS, and their targets were predicted
using Swiss Target Prediction databases. The targets of anxiety disorders were obtained by
GeneCards, DisGeNET, and OMIM databases. The STRING database was used to construct the
protein-protein interaction networks, and the DAVID database was used to carry out GO enrichment
and KEGG pathway enrichment analysis. The EOFHCB-components-targetspathways-
anxiety disorders network was constructed by Cytoscape software (Version 3.10.0).
Finally, the result was verified by molecular docking.

Results:
28 chemical components were identified by GC-MS, including 3-furanmethanol
(28.43%), 2-methyl-1-butanol (27.13%), nerolidol (10.62%), and so on, which correspond to 241
potential targets. Several 2440 biological processes, 187 cellular compositions, and 311 molecular
functions were enriched by GO enrichment analysis and 174 pathways by KEGG enrichment
analysis. The key targets are PTGS 2, SRC, DRD 2, ESR 1, MAOB, and SLC6A4. The most important
pathway is the neuroactive ligand-receptor interaction.

result:
28 chemical components were identified by GC-MS, including 3-Furanmethanol(28.43%), 2-methyl-1-Butanol(27.13%), Nerolidol (10.62%) and so on, which correspond to 241 potential targets. 2440 biological processes, 187 cellular composition and 311 molecular functions were enriched by GO enrichment analysis, and 174 pathways by KEGG enrichment analysis . The key targets are PTGS 2, SRC, DRD 2, ESR 1, MAOB, and SLC6A4. The most important pathway is the neuroactive ligand-receptor interaction.

Conclusion:
EOFHCB exerts its therapeutic effects on anxiety disorders through multicomponents,
multi-targets, and multi-pathways, which provided new ideas and methods for the
in-depth research of aromatic Chinese medicine in the treatment of anxiety disorders.
Unveiling the Significance of MRP 1 in Achieving Complete
Remission Following Induction Therapy in Acute Myeloid
Leukemia
Authors: Kamil Saba , Kouser Shaheen , Naeem Nadia , Farroqui Waqas , Sharafat Shaheen , Khan Farrukh Ali , Haider Ghulam , Kamil Noor , Ali Raahim , Abbass Farah Fatima , Khan Nehad , Khan Ramsha 
Published: July 2024

Background:
Increased expression of MRP 1 in AML patients results in the
efflux of drugs from the cells, preventing the patient from achieving remission or
potentially leading to relapse. Several studies have demonstrated that early
identification of ABC transporter may yield favorable outcomes.

Aims and objectives:
The objectives of the study were to investigate the correlation
between MRP 1 gene expression and MRP 1 protein levels and the response to
remission induction in AML patients.

Method:
A total of 40 AML patients were recruited from March 2021 to June 2022.
Peripheral blood was collected in two tubes (yellow and purple top) to assess the MRP
1 gene and protein. For MRP 1 gene assessment, RNA was isolated from blood
samples, cDNA was prepared, and qRT-PCR was performed to analyze gene
expression. The relationship between the gene and complete remission was
determined. Identification of MRP 1 protein was conducted using ELISA, and the
relationship between protein levels and complete remission (CR) was explored.

Results:
Most of the patients were aged between 25 and 39 years, encompassing
both males and females. This study observed a clinical correlation between MRP 1
gene expression and complete remission. The findings revealed that 69.2 percent of
patients with high gene expression failed to achieve complete remission, whereas the
analysis of MRP 1 protein in relation to complete remission showed no statistical
significance. The MRP1 gene showed high expression (66.7%) in patients with FLT3
mutation, whereas low expression of MRP1 was associated with a high occurrence
(60%) of NMP1 mutation.

Conclusion:
Further comprehensive multicenter studies with larger sample sizes are
required to validate the findings of this study. It is recommended to pinpoint the
mechanism and regulation of MRP 1 and its interaction with other molecular pathways
Synthesis of Some New Chiral Triazole-oxazoline Derivatives
Authors: Dong Hong-Ru 
Published: July 2024

:
Some new (S)-2-[1-aryl-5-methyl-1H-1,2,3-triazol-4-yl]-4-benzyl-4,5-dihydro-ox-azoline were synthesized by the reaction of (S)-N-(1-hydroxy-3-phenylpropan-2-yl)-1-aryl-5-methyl-1H-1,2,3-triazole-4-carboxamides which were prepared from aromatic amine as start-ing materials, with p-toluenesulfonyl chloride, triethylamine and DMAP. The structures were characterized by 1H NMR, 13C NMR, MS and IR. The synthesized chiral triazole-oxazoline was used as a ligand in the Diels-Alder asymmetric catalytic reaction between 3-allyl-1,3-ox-azolidin-2-ketone and 2-methyl-1,3-butadiene, using PdCl2 as catalyst. (S)-3-(4-methylcyclo-hexe-3-ene-1-formyl)-1,3-oxazolidin-2-one was obtained.

Background:
The chiral triazole-oxazoline ligands are rarely reported.

Objective:
The aim of the study was to synthsize some new chiral triazole-oxazoline ligands (S)-4-benzyl-2-(1-aryl-5-methyl-1H-1,2,3-triazole-4-yl)-4,5-dihydrooxazoline (5a-g).

Methods:
The one-pot methods of oriented synthesis were adopted. This study provides a sim-ple and effective method for the synthesis of new chiral triazole-oxazoline derivatives.

Results:
The some new chiral the triazole-oxazoline ligands (S)-4-benzyl-2-(1-aryl-5-methyl-1H-1,2,3-triazole-4-yl)-4,5-dihydrooxazoline (5a-g) were synthesized and the asymmetric Diels-Alder cyclization of 3-allyl-1,3-oxazolidin-2-ketone and 2-methyl-1,3-butadiene was catalyzed by PdCl2 using the synthesized (S)-4-triazole-oxazoline ligands.

Conclusion:
Some new (S)-4-benzyl-2-(1-aryl-5-methyl-1H-1,2,3-triazole-4-yl)-4,5-dihydro-oxazoline was synthesized by corresponding N-[(S)-1-hydroxy-3-phenylpropan-2-yl]-1-aryl-5-methyl-1H-1,2,3-triazole-4-formamide, through one-pot oriented synthesis method. After preliminary evaluation, the chiral triazoline-oxazoline ligands, in which 1,2,3-triazole rings, like pyridine-type rings, chiral materials were saved and replace one oxazoline ring in the di-oxazoline ligands for asymmetric catalytic reactions.
Anti-cancer Activity Evaluation of Naphthalenonic and Chromanonic Spiroisoxazoline Derivatives as Selective COX-2 Inhibitors on HT29 Cell Lines
Authors: Kalhor Hourieh , Movahhed Tahereh Komeili , Mousavi Shokoufeh , Qomi Masoumeh Sadri , Abolhasani Ahmad , Mirani Masoumeh , Rad Minoo Hosseini , Heidari Fatemeh , Abolhasani Hoda 
Published: July 2024

Background:
Cyclooxygenase-2 (COX-2) is induced in response to proinflammatory
conditions, and it is not only a key enzyme in the inflammatory process, but also seems to be
highly expressed in various types of cancer cells. On the other hand, it is well documented that
chemical compounds with spiro scaffolds in their structure could be effective chemical agents
against cancer types.

Objective:
In this study, the cytotoxicity effects of spiroisoxazoline derivatives containing naphthalinone and chromanone spiro-bridge were investigated.

Methods:
The cytotoxicity effects of compounds 7a-7h were evaluated by performing the MTT
assay on the HT-29 (colorectal cancer), MCF-7 (breast cancer), and HEK-293 (normal kidney)
cell lines. After that, a compound with high yield and remarkable cytotoxic activity was selected
to analyze the cell cycle and apoptosis mechanism.

Results:
The most effective cytotoxic activity was observed on HT-29 and MCF-7 cell lines of
compounds 7b (IC50 value: 1.07±0.28 µM) and 7f (IC50 value: 11.92±1.07 µM). None of the
compounds had a toxic effect on normal HEK-293 cells, except for compound 7g with an IC50
value of 21.30±16.14 µM, whose effect was much lower than that of cisplatin and doxorubicin,
known as anti-cancer agents. Subsequently, compound 7e with significant yield and cytotoxic
activity was investigated to evaluate cell cycle and apoptosis. The result showed that compound
7e induced significant G0/G1 cell cycle arrest and apoptosis in HT-29 cells

Conclusion:
The selective COX-2 inhibitor compounds with spiroisoxazoline core structure
could be suitable scaffolds for cytotoxic effects.
COVID-19 and Digestive Diseases: A Comprehensive Review on
Pathophysiology and Clinical Management
Authors: Ibrahim Noha E. , Mohamed Hassan Fatma 
Published: July 2024

Abstract:
A serious pandemic has been presented by the Severe Acute Respiratory Syndrome Coronavirus
2 (SARS-CoV-2), a coronavirus that causes the severe acute respiratory infection known
as Coronavirus disease 2019 (COVID-19). It has become a major health hazard that affects people all
around the world. Although the respiratory symptoms are the main manifestations of COVID-19,
several extrapulmonary manifestations have been observed, including cardiovascular, renal, and
gastrointestinal symptoms. The digestive system may be an additional or non-traditional pathway for
COVID-19 to spread and manifest as Angiotensin-Converting Enzyme 2 (ACE2), the entry point of
SARS-CoV-2 into the cells is present in the gastrointestinal tract and liver. Gastrointestinal symptoms,
such as vomiting, anorexia, nausea, and diarrhea, are infrequent in COVID-19 patients; however,
some of these symptoms may manifest independently of other respiratory symptoms. Also,
SARS-CoV-2 virus can cause liver and pancreatic damage. Studying the pathogenic mechanisms of
COVID-19 in the digestive system could aid in improving patient diagnosis and treatment. The review
aims to provide an overview of the mechanisms, symptoms, and management of SARS-CoV-
2's effects on the digestive system. Hence, medical professionals would be aware of the digestive
symptoms associated with COVID-19 and would promptly alter treatment regimens for patients exhibiting
abnormal hepatic and gastrointestinal manifestations.