bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Exposure Dilemma: Qualitative Study of Medical Student Opinions and Perceptions of Radiology
Authors: Visscher Kari L. , Nassrallah Georges , Faden Lisa , Wiseman Daniele 
Published: May 2015

Purpose According to a national survey of over 900 Canadian medical students, the stereotype of an isolated radiologist working in a dark room persists. The purpose of this study is to use qualitative methods to explore the ways exposure to radiology in medical school impacts students’ opinions and perceptions of radiology and radiologists. Methods After receiving ethics approval, 4 focus groups were conducted, 1 per year of undergraduate medical training at Western University. The transcribed audio recordings and accompanying field notes, together with the open-ended questions obtained from the national survey, were analyzed using thematic analysis. Results Five hundred sixty students in medical school years 1 and 2 (preclerkship) participated in the national survey and 18 in the focus groups; 336 students in years 3 and 4 [clerkship] participated in the national survey and 10 in the focus groups. Three major findings emerged from the analysis of the data. First, stereotypes are perpetuated mainly through informal interactions. Second, there is limited exposure to radiology and radiologists in medical school, especially in preclerkship. Third, students want to know what to expect if they choose a career in radiology. Conclusions Medical students, especially those in preclerkship, are seeking accurate information to modify or reinforce radiology stereotypes. Limited exposure makes interactions with students impactful and mentorship essential. Students want meaningful interactions with radiologists and radiology residents.
Hypnoanesthesia in Vascular Access
Authors: Bierman Steven F. , Sivieri Irma S. 
Published: May 2015

AbstractPurpose: A case is presented wherein hypnosis alone provided anesthesia for the ultrasound-guided placement of a device into right basilic vein. This is the first reported case of hypnoanesthesia for ultrasound-guided vascular access.Method: Ericksonian hypnosis was employed by the operator while a second clinician performed the vascular access procedure. The general method of induction and the anesthetic suggestions are disclosed and discussed.Results: The patient's experience was painless and, by her own repeated reports, pleasurable.Conclusions: Hypnosis is merely a refinement of everyday communication wherein ideas are expressed to increase the likelihood of their actualization. This case illustrates how a few carefully chosen sentences can alter a vascular access patient's entire experience.
The Epidemiology of Prehospital Emergency Responses for Older Adults in a Provincial EMS System
Authors: Goldstein Judah , Jensen Jan L. , Carter Alix J. E. , Travers Andrew H. , Rockwood Kenneth 
Published: May 2015

AbstractObjectivesSocietal aging is expected to impact the use of emergency medical services (EMS). Older adults are known as high users of EMS. Our primary objective was to quantify the rate of EMS use by older adults in a Canadian provincial EMS system. Our secondary objective was to compare those transported to those not transported.MethodsWe analysed data from a provincial EMS database for emergency responses between January 1, 2010 and December 31, 2010 and included all older adults (≥65 years) requesting EMS for an emergency call. We described EMS use in relation to age, sex, and resources.ResultsThere were 30,653 emergency responses for older adults in 2010, representing close to 50% of the emergency call volume and an overall response rate of 202.8 responses per 1,000 population 65 years and older. The mean age was 79.9±8.5 years for those 57.3% who were female. The median paramedic-determined Canadian Triage and Acuity Scale (CTAS) score was 3 and the mean on-scene time was 24.2 minutes. Non-transported calls (12.3%) for the elderly involved predominantly (54.9%) female patients of similar mean age (78.3 years) but lower acuity (CTAS 5) and longer average on-scene times (32.6 minutes).ConclusionsWe confirmed the increasingly high rate of EMS use with age to be consistent with other industrialized populations. The low-priority and non-transport calls by older adults consumed considerable resources in this provincial system and might be the areas most malleable to meet the challenges facing EMS systems.
MAGDALENE VON DEWALL (1927–2014): A PORTRAIT
Authors: von Falkenhausen Lothar 
Published: May 2015

AbstractMagdalene von Dewall was the only anthropologically oriented specialist in East and Southeast Asian archaeology in Germany in her generation. Her scholarly work on chariots, Dian bronzes, funerary archaeology, and other topics, was often far ahead of its time when published, and it remains worth reading. This article attempts to recount Magdalene von Dewall's biography and intellectual lineage and to characterize her scholarly contributions. It also describes how, largely thanks to Magdalene von Dewall's assiduous efforts, her field of study has gradually gained a certain measure of academic recognition in Germany during recent years.
Carbapenems Versus Piperacillin-Tazobactam for Bloodstream Infections of Nonurinary Source Caused by Extended-Spectrum Beta-Lactamase–Producing Enterobacteriaceae
Authors: Ofer-Friedman Hadas , Shefler Coral , Sharma Sarit , Tirosh Amit , Tal-Jasper Ruthy , Kandipalli Deepthi , Sharma Shruti , Bathina Pradeep , Kaplansky Tamir , Maskit Moran , Azouri Tal , Lazarovitch Tsilia , Zaidenstein Ronit , Kaye Keith S. , Marchaim Dror 
Published: May 2015

A recent, frequently quoted study has suggested that for bloodstream infections (BSIs) due to extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBL) Escherichia coli, treatment with β-lactam/β-lactamase inhibitors (BLBLIs) might be equivalent to treatment with carbapenems. However, the majority of BSIs originate from the urinary tract. A multicenter, multinational efficacy analysis was conducted from 2010 to 2012 to compare outcomes of patients with non-urinary ESBL BSIs who received a carbapenem (69 patients) vs those treated with piperacillin-tazobactam (10 patients). In multivariate analysis, therapy with piperacillin-tazobactam was associated with increased 90-day mortality (adjusted odds ratio, 7.9, P=.03). For ESBL BSIs of a non-urinary origin, carbapenems should be considered a superior treatment to BLBLIs.Infect Control Hosp Epidemiol 2015;36(8):981–985
The Likelihood of Hospital Readmission Among Patients With Hospital-Onset Central Line–Associated Bloodstream Infections
Authors: Khong Carolyn J. , Baggs James , Kleinbaum David , Cochran Ronda , Jernigan John A. 
Published: May 2015

OBJECTIVETo determine whether central line–associated bloodstream infections (CLABSIs) increase the likelihood of readmission.DESIGNRetrospective matched cohort study for the years 2008–2009.SETTINGAcute care hospitals.PARTICIPANTSMedicare recipients. CLABSI and readmission status were determined by linking National Healthcare Safety Network surveillance data to the Centers for Medicare and Medicaid Services’ Medical Provider and Analysis Review in 8 states. Frequency matching was used on International Classification of Diseases, Ninth Revision, Clinical Modification procedure code category and intensive care unit status.METHODSWe compared the rate of readmission among patients with and without CLABSI during an index hospitalization. Cox proportional hazard analysis was used to assess rate of readmission (the first hospitalization within 30 days after index discharge). Multivariate models included the following covariates: race, sex, length of index hospitalization stay, central line procedure code, Gagne comorbidity score, and individual chronic conditions.RESULTSOf the 8,097 patients, 2,260 were readmitted within 30 days (27.9%). The rate of first readmission was 7.1 events/person-year for CLABSI patients and 4.3 events/person-year for non-CLABSI patients (P<.001). The final model revealed a small but significant increase in the rate of 30-day readmissions for patients with a CLABSI compared with similar non-CLABSI patients. In the first readmission for CLABSI patients, we also observed an increase in diagnostic categories consistent with CLABSI, including septicemia and complications of a device.CONCLUSIONSOur analysis found a statistically significant association between CLABSI status and readmission, suggesting that CLABSI may have adverse health impact that extends beyond hospital discharge.Infect Control Hosp Epidemiol 2015;36(8):886–892
A review of 733 published trials on Bio-Mos®, a mannan oligosaccharide, and Actigen®, a second generation mannose rich fraction, on farm and companion animals.
Authors: Spring P. , Wenk C. , Connolly A. , Kiers A. 
Published: May 2015

SummaryMannan-oligosaccharides (MOS), as zootechnical feed ingredients, are widely used in animal nutrition. MOS has been commercially available since the launch of Bio-Mos® in the early 1990's and has a substantial body of scientific papers and practical examples of its efficacy. Since 1999, the use of MOS in animal feed has become more prominent, mainly due to the European ban on prophylactic antibiotic growth promoters in animal feed. MOS, with its ability to bind and limit the colonisation of gut pathogens, has proven to be an effective solution for antibiotic-free diets, as well as providing support for immunity and digestion. MOS has been shown to improve gastrointestinal health, thus improving wellbeing, energy levels and performance. Most MOS products, particularly those that have been scientifically developed, derive from the cell wall of the yeast,Saccharomyces cerevisiae. In 2009, a mannose-rich fraction (MRF) product was commercially launched as a ‘second generation’ of these MOS-type products, with enhanced activities in immune modulation and intestinal health. The purpose of this paper is to review the existing data on the benefits of MOS for all species of animals, discuss its mechanisms of actionin vivoand compare the benefits of using second generation MRF to original MOS.
A thin drop sliding down an inclined plate
Authors: Benilov E. S. , Benilov M. S. 
Published: May 2015

We examine two- and three-dimensional drops steadily sliding down an inclined plate. The contact line of the drop is governed by a model based on the Navier-slip boundary condition and a prescribed value for the contact angle. The drop is thin, so the lubrication approximation can be used. In the three-dimensional case, we also assume that the drop is sufficiently small (its size is smaller than the capillary scale). These assumptions enable us to determine the shape of the drop and derive an asymptotic expression for its velocity. For three-dimensional drops, this expression is matched to a qualitative estimate of Kim et al. (J. Colloid Interface Sci., vol. 247, 2002, pp. 372–380) obtained for arbitrary drops, i.e. not necessarily thin and small. The matching fixes an undetermined coefficient in Kim, Lee and Kang’s estimate, turning it into a quantitative result.
Lipid-rich diet enhances L-cell density in obese subjects and in mice through improved L-cell differentiation
Authors: Aranias Thomas , Grosfeld Alexandra , Poitou Christine , Omar Amal Ait , Le Gall Maude , Miquel Sylvie , Garbin Kévin , Ribeiro Agnès , Bouillot Jean-Luc , Bado André , Brot-Laroche Edith , Clément Karine , Leturque Armelle , Guilmeau Sandra , Serradas Patricia 
Published: May 2015

AbstractThe enterohormone glucagon-like peptide-1 (GLP-1) is required to amplify glucose-induced insulin secretion that facilitates peripheral glucose utilisation. Alteration in GLP-1 secretion during obesity has been reported but is still controversial. Due to the high adaptability of intestinal cells to environmental changes, we hypothesised that the density of GLP-1-producing cells could be modified by nutritional factors to prevent the deterioration of metabolic condition in obesity. We quantified L-cell density in jejunum samples collected during Roux-en-Y gastric bypass in forty-nine severely obese subjects analysed according to their fat consumption. In mice, we deciphered the mechanisms by which a high-fat diet (HFD) makes an impact on enteroendocrine cell density and function. L-cell density in the jejunum was higher in obese subjects consuming >30 % fat compared with low fat eaters. Mice fed a HFD for 8 weeks displayed an increase in GLP-1-positive cells in the jejunum and colon accordingly to GLP-1 secretion. The regulation by the HFD appears specific to GLP-1-producing cells, as the number of PYY (peptide YY)-positive cells remained unchanged. Moreover, genetically obese ob/ob mice did not show alteration of GLP-1-positive cell density in the jejunum or colon, suggesting that obesity per se is not sufficient to trigger the mechanism. The higher L-cell density in HFD-fed mice involved a rise in L-cell terminal differentiation as witnessed by the increased expression of transcription factors downstream of neurogenin3 (Ngn3). We suggest that the observed increase in GLP-1-positive cell density triggered by high fat consumption in humans and mice might favour insulin secretion and therefore constitute an adaptive response of the intestine to balance diet-induced insulin resistance.
Intestinal B0AT1 (SLC6A19) and PEPT1 (SLC15A1) mRNA levels in European sea bass (Dicentrarchus labrax) reared in fresh water and fed fish and plant protein sources
Authors: Rimoldi Simona , Bossi Elena , Harpaz Sheenan , Cattaneo Anna Giulia , Bernardini Giovanni , Saroglia Marco , Terova Genciana 
Published: May 2015

AbstractThe objective of the present study was to examine the effect of diets with descending fish meal (FM) inclusion levels and the addition of salt to the diet containing the lowest FM level on growth performances, feed conversion ratio, and intestinal solute carrier family 6 member 19 (SLC6A19) and oligopeptide transporter 1 (PEPT1) transcript levels, in freshwater-adapted European sea bass (Dicentrarchus labrax). We first isolated by molecular cloning and sequenced a full-length cDNA representing the neutral amino acid transporter SLC6A19 in sea bass. The cDNA sequence was deposited in GenBank database (accession no. KC812315). The twelve transmembrane domains and the ‘de novo’ prediction of the three-dimensional structure of SLC6A19 protein (634 amino acids) are presented. We then analysed diet-induced changes in the mRNA copies of SLC6A19 and PEPT1 genes in different portions of sea bass intestine using real-time RT-PCR. Sea bass were fed for 6 weeks on different diets, with ascending levels of fat or descending levels of FM, which was replaced with vegetable meal. The salt-enriched diet was prepared by adding 3 % NaCl to the diet containing 10 % FM. SLC6A19 mRNA in the anterior and posterior intestine of sea bass were not modulated by dietary protein sources and salt supplementation. Conversely, including salt in a diet containing a low FM percentage up-regulated the mRNA copies of PEPT1 in the hindgut. Fish growth correlated positively with the content of FM in the diets. Interestingly, the addition of salt to the diet containing 10 % FM improved feed intake, as well as specific growth rate and feed conversion ratio.
Impact of monoamine-related gene polymorphisms on hippocampal volume in treatment-resistant depression
Authors: Phillips Jennifer Lynne , Batten Lisa Ann , Tremblay Philippe , Aldosary Fahad , Du Lisheng , Blier Pierre 
Published: May 2015

ObjectiveIn major depressive disorder (MDD), single nucleotide polymorphisms (SNPs) in monoaminergic genes may impact disease susceptibility, treatment response, and brain volume. The objective of this study was to examine the effect of such polymorphisms on hippocampal volume in patients with treatment-resistant MDD and healthy controls. Candidate gene risk alleles were hypothesised to be associated with reductions in hippocampal volume.MethodsA total of 26 outpatients with treatment-resistant MDD and 27 matched healthy controls underwent magnetic resonance imaging and genotyping for six SNPs in monoaminergic genes [serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), serotonin 1A and 2A receptors (HTR1A and HTR2A), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF)]. Hippocampal volume was estimated using an automated segmentation algorithm (FreeSurfer).ResultsHippocampal volume did not differ between patients and controls. Within the entire study sample irrespective of diagnosis, C allele-carriers for both the NET−182 T/C [rs2242446] and 5-HT1A−1019C/G [rs6295] polymorphisms had smaller hippocampal volumes relative to other genotypes. For the 5-HTTLPR (rs25531) polymorphism, there was a significant diagnosis by genotype interaction effect on hippocampal volume. Among patients only, homozygosity for the 5-HTTLPR short (S) allele was associated with smaller hippocampal volume. There was no association between the 5-HT2A, COMT, and BDNF SNPs and hippocampal volume.ConclusionThe results indicate that the volume of the hippocampus may be influenced by serotonin- and norepinephrine-related gene polymorphisms. The NET and 5-HT1A polymorphisms appear to have similar effects on hippocampal volume in patients and controls while the 5-HTTLPR polymorphism differentially affects hippocampal volume in the presence of depression.
Inflammatory and metabolic responses to high-fat meals with and without dairy products in men
Authors: Schmid Alexandra , Petry Nicolai , Walther Barbara , Bütikofer Ueli , Luginbühl Werner , Gille Doreen , Chollet Magali , McTernan Philip G. , Gijs Martin A. M. , Vionnet Nathalie , Pralong François P. , Laederach Kurt , Vergères Guy 
Published: May 2015

Postprandial inflammation is an important factor for human health since chronic low-grade inflammation is associated with chronic diseases. Dairy products have a weak but significant anti-inflammatory effect on postprandial inflammation. The objective of the present study was to compare the effect of a high-fat dairy meal (HFD meal), a high-fat non-dairy meal supplemented with milk (HFM meal) and a high-fat non-dairy control meal (HFC meal) on postprandial inflammatory and metabolic responses in healthy men. A cross-over study was conducted in nineteen male subjects. Blood samples were collected before and 1, 2, 4 and 6 h after consumption of the test meals. Plasma concentrations of insulin, glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TAG and C-reactive protein (CRP) were measured at each time point. IL-6, TNF-α and endotoxin concentrations were assessed at baseline and endpoint (6 h). Time-dependent curves of these metabolic parameters were plotted, and the net incremental AUC were found to be significantly higher for TAG and lower for CRP after consumption of the HFM meal compared with the HFD meal; however, the HFM and HFD meals were not different from the HFC meal. Alterations in IL-6, TNF-α and endotoxin concentrations were not significantly different between the test meals. The results suggest that full-fat milk and dairy products (cheese and butter) have no significant impact on the inflammatory response to a high-fat meal.
Cytokine and growth factor profiling in patients with the metabolic syndrome
Authors: Mirhafez Seyed Reza , Pasdar Alireza , Avan Amir , Esmaily Habibollah , Moezzi Atefeh , Mohebati Mohsen , Meshkat Zahra , Mehrad-Majd Hassan , Eslami Saied , Rahimi Hamid Reza , Ghazavi Hamed , Ferns Gordon A. , Ghayour-Mobarhan Majid 
Published: May 2015

The metabolic syndrome (MetS) is associated with a pro-inflammatory milieu that may partially account for its association with an increased cardiovascular risk. We aimed to (1) evaluate the serum concentrations of twelve cytokines and growth factors (epidermal growth factor (EGF), interferon-γ (IFN-γ), IL-1α/-1β/-2/-4/-6/-8/-10, monocyte chemoattractant protein-1 (MCP-1), TNF-α and vascular endothelial growth factor (VEGF)) in 303 individuals with or without the MetS; and (2) explore their relationship with the presence of the MetS. Patients with the MetS had significantly higher serum concentrations of IFN-γ, EGF, IL-1α/-1β/-2/-4/-6/-8/-10, MCP-1 and TNF-α, whilst serum VEGF concentrations were markedly lower compared with the control group (e.g. 38·55 v. 82·18 pg/ml; P< 0·05). Amongst these parameters, IFN-γ and IL-1α emerged as the most significant independent predictors of the MetS. In conclusion, our findings demonstrate that patients with the MetS had an altered blood cytokine and growth factor profile that may partially account for its adverse clinical outcomes. Further prospective studies in larger multi-centre settings are required to unravel the role and association of the emerging biomarkers with the MetS and their implication in therapeutic intervention.
Abnormalities inmyo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietarymyo-inositol supplementation
Authors: Croze Marine L. , Géloën Alain , Soulage Christophe O. 
Published: May 2015

We previously reported that a chronic supplementation withmyo-inositol (MI) improved insulin sensitivity and reduced fat accretion in mice. We then tested the potency of such dietary intervention in the prevention of insulin resistance in C57BL/6 male mouse fed a high-fat diet (HFD). In addition, some abnormalities in inositol metabolism were reported to be associated with insulin resistance in several animal and human studies. We then investigated the presence of such anomalies (i.e. inosituria and an inositol intra-tissue depletion) in this diet-induced obesity (DIO) mouse model, as well as the potential benefit of a MI supplementation for inositol intra-tissue deficiency correction. HFD (60 % energy from fat) feeding was associated with inosituria and inositol intra-tissue depletion in the liver and kidneys. MI supplementation (0·58 mg/g per d) restored inositol pools in kidneys (partially) and liver (fully). HFD feeding for 4 months induced ectopic lipid redistribution to liver and muscles, fasting hyperglycaemia and hyperinsulinaemia, insulin resistance and obesity that were not prevented by MI supplementation, despite a significant improvement in insulin sensitivity parameterKinsulin tolerance testand a reduction in white adipose tissue (WAT) mass ( − 17 %,P< 0·05). MI supplementation significantly reduced fatty acid synthase activity in epididymal WAT, which might explain its beneficial, but modest, effect on WAT accretion in HFD-fed mice. Finally, we found some abnormalities in inositol metabolism in association with a diabetic phenotype (i.e. insulin resistance and fasting hyperglycaemia) in a DIO mouse model. Dietary MI supplementation was efficient in the prevention of inositol intra-tissue depletion, but did not prevent insulin resistance or obesity efficiently in this mouse model.