bluuebunny/crossref_metadata_2025_split huggingface dataset:
Light stress elicits soilborne disease suppression mediated by root-secreted flavonoids in Panax notoginseng
Authors: Fang Haiyan , Guo Cunwu , Mei Xinyue , Hao Minwen , Zhang Jiayin , Luo Lifen , Liu Haijiao , Liu Yixiang , Huang Huichuan , He Xiahong , Zhu Youyong , Yang Min , Zhu Shusheng 
Published: July 2024

Abstract
Developing disease-suppressive soils is an effective approach for managing soilborne diseases, which can be achieved through crop metabolism and root secretion modification to recruit beneficial soil microbiota. Many factors, such as light, can elicit and modify plant metabolomic activities, resulting in disease suppression. To investigate the impact of light, Panax notoginseng was planted in a greenhouse and forest, conditioned with three levels of light intensities, including the optimal (15% light transmittance of full light), suboptimal low (5% light transmittance of full light) and suboptimal high (30% light transmittance of full light) intensities. We assessed the rhizosphere microbiota of P. notoginseng and root rot disease caused by soilborne pathogen Ilyonectria destructans, and elucidated the mechanism. Results showed that suboptimal light conditions alleviated root rot disease of P. notoginseng by enriching beneficial microbiota in the rhizosphere. Both low and high light stresses enhanced the secondary metabolism profile in favor of plant defense, particularly the flavonoid pathway. Notably, high light stress demonstrated a robust ability to promote flavonoid metabolism and secretion, resulting in the enrichment of more beneficial microorganisms that suppressed the soilborne pathogen I. destructans. These findings highlight the potential for adjusting canopy light intensities to improve soil health and promote sustainable agriculture.
Comparative phylogeography and genetic diversity of two co-occurring anti-tropical krill species Hansarsia megalops and Thysanoessa gregaria in the Atlantic Ocean
Authors: Kulagin Dmirty N , Simakova Ulyana V , Lunina Anastasiia A , Vereshchaka Alexander L 
Published: July 2024

Abstract
Hansarsia megalops and Thysanoessa gregaria are two abundant krill species in the warm-temperate belts in the North and South Atlantic. This pattern of disjunct distribution, often referred to as anti-tropical (or bipolar), is a regular phenomenon among marine organisms that can appear at different taxonomic levels. Analysis of spatial genetic diversity based on variation of the mitochondrial cytochrome oxidase I (COI) gene was carried out to understand whether these broadly sympatric krill species have similar patterns in population structure and demographic history. The results suggested that the anti-tropical distribution of both species was driven by trans-equatorial migrations during different historical periods. We observed contrasting differences in genetic diversity between species coupled with similar patterns of genetic diversity and structure in disjunct populations on both sides of the equator. We also found additional genetically distinctive populations of T. gregaria in the South Atlantic in Subantarctic waters and showed that the Southern Subtropical Frontal Zone acts as a strong boundary between two genetically distinctive populations of T. gregaria. The results suggest that both species-specific habitat preferences and interactions between closely related species (congeners) may shape differences in population genetic diversity and structure among species.
KPP transition fronts in a one-dimensional two-patch habitat
Authors: Hamel François , Zhang Mingmin 
Published: July 2024

Abstract
This paper is concerned with the existence of transition fronts for a one-dimensional two-patch model with KPP reaction terms. Density and flux conditions are imposed at the interface between the two patches. We first construct a pair of suitable super- and subsolutions by making full use of information of the leading edges of two KPP fronts and gluing them through the interface conditions. Then, an entire solution obtained thanks to a limiting argument is shown to be a transition front moving from one patch to the other one. This propagating solution admits asymptotic past and future speeds, and it connects two different fronts, each associated with one of the two patches. The paper thus provides the first example of a transition front for a KPP-type two-patch model with interface conditions. To Professor James D. Murray in admiration and recognition of his great achievements in mathematical biology
Accelerating onchocerciasis elimination in humanitarian settings: lessons from South Sudan
Authors: Siewe Fodjo J N , Jada S R , Rovarini J , Bol Y Y , Carter J Y , Hadermann A , Lakwo T , Colebunders R 
Published: July 2024

Abstract
There is persistent meso- and hyperendemicity of onchocerciasis (river blindness) in South Sudan, a country that has endured armed conflict for many years. In 2018, Amref Health Africa, in collaboration with local communities, the South Sudan Ministry of Health and other stakeholders, initiated some interventions, among which was Innovative Approaches to Reduce the Burden of Disease Caused by Onchocerciasis (IARDO) project. This project implemented several strategies, including identifying areas where onchocerciasis elimination programs need strengthening, switching from annual to biannual community-directed treatment with ivermectin (CDTI), additional ivermectin administration to postpartum women and school children and a community-based ‘slash and clear’ vector control strategy. These measures resulted in increased CDTI coverage, fewer bites from blackfly vectors and decreased onchocerciasis-related morbidity. The feasibility of these interventions, low cost, national government support and community ownership suggest their long-term sustainability.
GuidingBand: Evaluating Speed, Precision and Accuracy of a Vibrotactile Hand Guidance System
Authors: Poncibi B , Waghwase Atish , Joshi Anirudha 
Published: July 2024

Abstract
Computerized tactile guidance systems can potentially help in human visual perception tasks such as identifying a desired object in a collection of similar objects. We designed a wrist-wearable tactile guidance system called GuidingBand that provides vibrational cues to help the user pick visual targets out of an array. We conducted three studies to systematically investigate the interplay of machine-led tactile guidance and human visual perception. The studies involve presenting visual targets to users on a screen and giving them visual search tasks. In Study 1, we identified the error rate of our guidance system. We presented participants (N=20) with arrays of identical, square targets to pick from, progressively reduced the target sizes and evaluated error rates for each size. Notably, we observed a 4% error rate at a target size of 10 mm. In Study 2, we compared the error rate of the guidance system with and without the help of human visual perception in a visual search task. We constructed a task that involved showing users an array of distractor rectangles (set sizes 2 to 10) varying only in length and asked them to identify the correct target that was previously shown to them. Participants (N=13) had fewer errors when they tried to identify targets with tactile guidance alone, followed by guidance and perception combined and perception alone. In Study 3, we had the same task as Study 2 but the distractor set sizes were larger (varying from 4 to 28), we had more participants (N=30) and measured errors and task time. While perception alone was the fastest, it was also the most error prone. The combined mode was faster and less error prone than guidance only mode, as expected, indicating that human–computer collaboration yielded the best performance.
The circadian rhythm as therapeutic target in inflammatory bowel disease
Authors: Post Zoë , Zilberstein Netanel F , Keshavarzian Ali 
Published: July 2024

Abstract
The primary objectives of the management of patients with inflammatory bowel disease (IBD) are to prevent IBD flares, prevent/delay disease progression and improve patients’ quality of life. To this end, one needs to identify risk factor(s) associated with flare-ups and disease progression. We posit that disruption of circadian rhythms is one of the key factors that is associated with risk of flare-up and disease progression. This hypothesis is based on published studies that show: (1) The circadian rhythm regulates many biological processes including multiple IBD-relevant biological processes that are critical in inflammatory/immune processes such as environment/microbe interaction, microbe/host interaction, intestinal barrier integrity and mucosal immunity—all central in the pathogenesis of IBD, and (2) Circadian machinery is the primary tool for the host to interact with the environment. Circadian misalignment results in a loss of preparedness of the host to respond and adjust to the environmental changes that could make the host more vulnerable to IBD flare-ups. In this review, we first provide an overview of circadian rhythms and its role in healthy and disease states. Then we present data to support our hypothesis that: (1) IBD patients have disrupted circadian rhythms (“social jet lag”) and (2) circadian misalignment and associated disrupted sleep decreases the resiliency of IBD patients resulting in microbiota dysbiosis, more disrupted intestinal barrier integrity and a more aggressive disease phenotype. We also show that circadian-directed interventions have a potential to mitigate the deleterious impact of disrupted circadian and improve IBD disease course.
Putting Freedom of Contract in its Place
Authors: Stone Rebecca 
Published: July 2024

AbstractI develop a novel, rights-based conception of contract—the “democratic conception”—that can deliver a justification for granting a sphere of freedom to contracting parties while setting principled limits on that grant. It justifies doctrines—including the penalty doctrine, the doctrine of substantial performance, a robust doctrine of changed circumstances, and a robust doctrine of unconscionability—that an influential group of contract theorists argue set unprincipled limits on the parties’ equal procedural freedom. My account shows how these doctrines can be rendered compatible with a robust principle of freedom of contract that is grounded in the parties’ rights.
The Role of the Army Medical Corps (MC) in the Caribbean Campaign of the Spanish American War
Authors: Nieves J Edwin , Stack Kathleen M , Pace April A 
Published: July 2024

Abstract
The 5th Army Medical Corps Caribbean campaigns provided valuable lessons on the noncombat hazards to troops and the challenges to the provision of care in a tropical theater of operations. The Army quickly adapted the lessons learnt for the invasion in Puerto Rico and future overseas expeditions.
The effect of AGN feedback on the Lyman-α forest signature of galaxy protoclusters at z∼ 2.3
Authors: Dong Chenze , Lee Khee-Gan , Cui Weiguang , Davé Romeel , Sorini Daniele 
Published: July 2024

ABSTRACT
The intergalactic medium in the vicinity of galaxy protoclusters are interesting testbeds to study complex baryonic effects such as gravitational shocks and feedback. Here, we utilize hydrodynamical simulations from the SIMBA and The Three Hundred suites to study the mechanisms influencing large-scale Lyman-$\alpha$ transmission in $2\lt z\lt 2.5$ protoclusters. We focus on the matter overdensity-Lyman-$\alpha$ transmission relation $(\delta _m-\delta _F)$ on Megaparsec-scales in these protoclusters, which is hypothesized to be sensitive to the feedback implementations. The lower density regions represented by the SIMBA-100 cosmological volume trace the power-law $\delta _m-\delta _F$ relationship often known as the fluctuating Gunn–Peterson approximation. This trend is continued into higher density regions covered by simulations that implement stellar feedback only. Simulations with active galactic nucleus (AGN) thermal and AGN jet feedback, however, exhibit progressively more Lyman-$\alpha$ transmission at fixed matter overdensity. Compared with the seven protoclusters observed in the COSMOS field, only two display the excess absorption expected from protoclusters. The others exhibit deviations: four show some increased transparency suggested by AGN X-ray thermal feedback models while the highly transparent COSTCO-I protocluster appears to reflect intense jet feedback. Discrepancies with the stellar-feedback-only model suggests processes at play beyond gravitational heating and/or stellar feedback as the cause of the protocluster transparencies. Some form of AGN feedback is likely at play in the observed protoclusters, and possibly long-ranged AGN jets in the case of COSTCO-I. While more detailed and resolved simulations are required to move forward, our findings open new avenues for probing AGN feedback at Cosmic Noon.
Combating air pollution significantly reduced air mercury concentrations in China
Authors: Feng Xinbin , Fu Xuewu , Zhang Hui , Wang Xun , Jia Longyu , Zhang Leiming , Lin Che-Jen , Huang Jen-How , Liu Kaiyun , Wang Shuxiao 
Published: July 2024

ABSTRACT
In the past decade, China has motivated proactive emission control measures that have successfully reduced emissions of many air pollutants. For atmospheric mercury, which is a globally transported neurotoxin, much less is known about the long-term changes in its concentrations and anthropogenic emissions in China. In this study, over a decade of continuous observations at four Chinese sites show that gaseous elemental mercury (GEM) concentrations continuously increased until the early 2010s, followed by significant declines at rates of 1.8%–6.1% yr−1 until 2022. The GEM decline from 2013 to 2022 (by 38.6% ± 12.7%) coincided with the decreasing concentrations of criteria air pollutants in China and were larger than those observed elsewhere in the northern hemisphere (5.7%–14.2%). The co-benefits of emission control measures contributed to the reduced anthropogenic Hg emissions and led to the GEM decline in China. We estimated that anthropogenic GEM emissions in China were reduced by 38%–50% (116–151 tons) from 2013 to 2022 using the machine-learning and relationship models.
CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis
Authors: Ikeda Aya , Meng Hongrui , Taniguchi Daisuke , Mio Muneyo , Funayama Manabu , Nishioka Kenya , Yoshida Mari , Li Yuanzhe , Yoshino Hiroyo , Inoshita Tsuyoshi , Shiba-Fukushima Kahori , Okubo Yohei , Sakurai Takashi , Amo Taku , Aiba Ikuko , Saito Yufuko , Saito Yuko , Murayama Shigeo , Atsuta Naoki , Nakamura Ryoichi , Tohnai Genki , Izumi Yuishin , Morita Mitsuya , Tamura Asako , Kano Osamu , Oda Masaya , Kuwabara Satoshi , Yamashita Toru , Sone Jun , Kaji Ryuji , Sobue Gen , Imai Yuzuru , Hattori Nobutaka 
Published: July 2024

Abstract
CHCHD2 and CHCHD10, linked to Parkinson's disease and amyotrophic lateral sclerosis-frontotemporal dementia (ALS), respectively, are mitochondrial intermembrane proteins that form a heterodimer. This study aimed to investigate the impact of the CHCHD2 P14L variant, implicated in ALS, on mitochondrial function and its subsequent effects on cellular homeostasis. The missense variant of CHCHD2, P14L, found in a cohort of patients with ALS, mislocalized CHCHD2 to the cytoplasm, leaving CHCHD10 in the mitochondria. Drosophila lacking the CHCHD2 ortholog exhibited mitochondrial degeneration. In contrast, human CHCHD2 P14L, but not wild-type human CHCHD2, failed to suppress this degeneration, suggesting that P14L is a pathogenic variant. The mitochondrial Ca2+ buffering capacity was reduced in Drosophila neurons expressing human CHCHD2 P14L. The altered Ca2+-buffering phenotype was also observed in cultured human neuroblastoma SH-SY5Y cells expressing CHCHD2 P14L. In these cells, transient elevation of cytoplasmic Ca2+ facilitated the activation of calpain and caspase-3, accompanied by the processing and insolubilization of TDP-43. These observations suggest that CHCHD2 P14L causes abnormal Ca2+ dynamics and TDP-43 aggregation, reflecting the pathophysiology of ALS.
Supersymmetric Expansion Algorithm and Complete Analytical Solution for the Hulthén and Anharmonic Potentials
Authors: Napsuciale M , Rodríguez S , Kirchbach M 
Published: July 2024

Abstract
An algorithm for providing analytical solutions to Schrödinger’s equation with nonexactly solvable potentials is elaborated. It represents a symbiosis between the logarithmic expansion method and the techniques of supersymmetric quantum mechanics as extended toward non-shape-invariant potentials. The complete solution to a given Hamiltonian $H_{0}$ is obtained from the nodeless states of the Hamiltonian $H_{0}$ and of a set of supersymmetric partners $H_{1}, H_{2},..., H_{r}$. The nodeless states (dubbed “edge” states) are unique and in general can be ground or excited states. They are solved using the logarithmic expansion which yields an infinite system of coupled first-order hierarchical differential equations, converted later into algebraic equations with recurrence relations which can be solved order by order. We formulate the aforementioned scheme, termed the “Supersymmetric Expansion Algorithm,” step by step and apply it to obtain for the first time the complete analytical solutions of the 3D Hulthén, and the 1D anharmonic, oscillator potentials.
Three-dimensional cultured human umbilical cord mesenchymal stem cells attenuate pulmonary fibrosis by improving the balance of mitochondrial fusion and fission
Authors: Zhai Huifang , Jiang Mengqi , Zhao Yaqin , Wang Yujie , Zhang Haitong , Ji Yunxia , Song Xiaodong , Zhang Jinjin , Lv Changjun , Li Minge 
Published: July 2024

Abstract
Pulmonary fibrosis is a kind of fibrotic interstitial pneumonia with poor prognosis. Aging, environmental pollution, and coronavirus disease 2019 are considered as independent risk factors for pulmonary fibrogenesis. Consequently, the morbidity and mortality striking continues to rise in recent years. However, the clinical therapeutic efficacy is very limited and unsatisfactory. So it is necessary to develop a new effective therapeutic approach for pulmonary fibrosis. Human umbilical cord mesenchymal stem cells (hucMSCs) are considered as a promising treatment for various diseases because of their multiple differentiation and immunomodulatory function. The key bottleneck in the clinical application of hucMSCs therapy is the high-quality and large-scale production. This study used FloTrix miniSpin bioreactor, a three-dimensional (3D) cell culture system, for large-scale expansion of hucMSCs in vitro, and proved 3D cultured hucMSCs inhibited the differentiation of fibroblasts into myofibroblasts and myofibroblasts proliferation and migration, leading to slow down the development of pulmonary fibrosis. Further mechanistic studies clarified that hucMSCs reduced the amount of binding between circELP2 and miR-630, resulting in blocking YAP/TAZ translocation from cytoplasm to nucleus. This condition inhibited mitochondrial fusion and promoted mitochondrial fission, and ultimately improved fusion/fission balance and cellular homeostasis. To sum up, this work clarified the anti-fibrosis and mechanism of hucMSCs cultured from the 3D FloTrix miniSpin bioreactor. We hope to provide new ideas and new methods for the clinical transformation and industrialization of hucMSCs therapy.
A detailed survey of the murine limbus, its stem cell distribution, and its boundaries with the cornea and conjunctiva
Authors: Nureen Lamia , Biazik Joanna , Carnell Michael , Di Girolamo Nick 
Published: July 2024

Abstract
The narrow intersection between the cornea and conjunctiva, otherwise known as the limbus, is purported to harbor stem cells (SCs) that replenish the ocular surface epithelium throughout life. Damage to this site or depletion of its SCs can have dire consequences for eye health and vision. To date, various SC and keratin proteins have been used to identify the limbus, however, none could definitively mark its boundaries. Herein, we use the mouse as a model system to investigate whether structural and phenotypic features can be used to define the limbus and its boundaries with adjacent tissues. We demonstrate that differentially aligned blood and lymphatic vessels, intraepithelial nerves, and basal epithelial cellular and nuclei dimensions can be used as structural landmarks of the limbus. Identification of these features enabled approximation of the limbal expanse, which varied across distinct ocular surface quadrants, with the superior nasal and inferior temporal limbus being the widest and narrowest, respectively. Moreover, label-retaining SCs were unevenly distributed across the ocular circumference, with increased numbers in the superior temporal and inferior temporal moieties. These findings will heighten our current understanding of the SC niche, be beneficial for accurately predicting SC distribution to improve their isolation and devising efficacious cell therapies, and importantly, aid the ongoing search for novel SC markers.
Beyond the appearances: exploring complexities in anaphylaxis differential diagnosis
Authors: Nicola Stefania , Lo Sardo Luca , Borrelli Richard , Quinternetto Anna , Rashidy Nicolò , Brussino Luisa 
Published: July 2024

Purpose of review
Anaphylaxis is a severe, and potentially life-threatening hypersensitivity reaction whose diagnosis is based on clinical signs and symptoms and their prompt recognition. The presence of mimics and unusual presentations necessitate a careful evaluation and expertise in the field, due to potential diagnostic errors and hence a delay in the treatment.
The aim of this review is to analyze and make an overview of the potential differential diagnosis of anaphylaxis, focusing on the clinical challenges of recognizing these conditions effectively among similar others.

Recent findings
The presence of mimics and unusual presentations of anaphylaxis necessitate a careful evaluation, emphasizing the importance of a comprehensive diagnostic approach.
Tryptase is well known marker of mast cells activation, and a useful tool assisting the diagnosis of anaphylaxis, helping to differentiate it from atypical mimickers.

Summary
The differential diagnosis of anaphylaxis comprises a very wide setting, and a systematic approach assessing different categories of cardiovascular, skin, respiratory airway, neuropsychiatric, and hematologic systems, can facilitate recognition of the correct diagnosis of this complex and life-threatening condition.
Chronic urticaria: not only after COVID-19 vaccination
Authors: Yacoub Mona-Rita , Ferlito Arianna , Nettis Eustachio 
Published: July 2024

Purpose of review
To resume the current literature about vaccination and the onset of chronic urticaria.

Recent findings
The recent large-scale vaccination against SARS-CoV-2 targeting elderly, adult and children, has highlighted how vaccines can trigger onset or exacerbation of chronic urticaria.

Summary
COVID-19 vaccines may act as triggers in the development of chronic spontaneous urticaria. More data regarding the other vaccines are necessary to evaluate a similar potential role. Proper education of patients with vaccine-induced chronic urticaria is essential to avoid vaccination hesitancy.