bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of pre‐pregnancy body mass index and gestational weight gain on postpartum pelvic floor muscle morphology and function in Chinese primiparous women: A retrospective cohort study
Authors: Shao Fei‐Xue , He Ping , Mao Ya‐Jing , Liu Huan‐Rong , Wan Sheng , Qin Shi , Luo Wei‐Jia , Cheng Jie‐Jun , Ren Min , Hua Xiao‐Lin 
Published: August 2024

AbstractObjectiveOur study aimed to investigate the association between maternal pre‐pregnancy body mass index (BMI), gestational weight gain (GWG), and impaired pelvic floor muscle (PFM) morphology and function during the early postpartum period.MethodsThis retrospective cohort study was conducted at Shanghai First Maternity and Infant Hospital from December 2020 to December 2022. A total of 1118 primiparous women with singleton pregnancies who underwent vaginal deliveries and participated in postpartum PFM assessments were included. Maternal pre‐pregnancy BMI and GWG were considered as exposures. PFM morphology and function impairment were the primary outcomes. PFM morphology impairment, defined as levator ani muscle avulsion, was assessed using transperineal ultrasound. PFM function impairment, manifested as diminished PFM fiber strength, was assessed through vaginal manometry. Multivariable logistic regression analysis was employed to calculate adjusted odds ratios (aOR) with 95% confidence intervals (CI). Restricted cubic spline models were used to validate and visualize the relationship.ResultsWomen with lower pre‐pregnancy BMI were at an increased risk of levator ani muscle avulsion (aOR = 1.73, 95% CI: 1.10–2.70, P = 0.017), particularly when combined with excessive GWG during pregnancy (aOR = 3.20, 95% CI: 1.15–8.97, P = 0.027). Lower pre‐pregnancy BMI was also identified as an independent predictor of PFM weakness (aOR = 1.53, 95% CI: 1.08–2.16, P = 0.017 for type I fiber injuries). Notably, regardless of the avulsion status, both underweight and overweight/obese women faced an elevated risk of reduced PFM strength (aOR = 1.74, 95% CI: 1.17–2.59, P = 0.006 for underweight women with type I fiber injuries; aOR = 1.67, 95% CI: 1.06–2.64, P = 0.027; and aOR = 1.73, 95% CI: 1.09–2.76, P = 0.021 for overweight/obese women with type I and type II fibers injuries, respectively).ConclusionsBoth lower and higher pre‐pregnancy BMI, as well as excessive GWG, were strongly associated with PFM impairments. These findings highlighted the critical importance of comprehensive weight management throughout pregnancy to effectively promote women's pelvic health.
Application of Non‐Immersive Virtual Reality in Cerebral Palsy Children: A Systematic Review
Authors: Dwarkadas Agrawal Luckykumar , Talasila Viswanath , Kirmani Sheeraz , Challa Rama Krishna , Srinivasa K. G. 
Published: August 2024

ABSTRACTCerebral palsy (CP) is a movement disorder caused by brain damage. Virtual reality (VR) can improve motor function and daily life activities in CP patients. This systematic review examines the use of non‐immersive VR in treating CP children. The objective is to evaluate the effectiveness of non‐immersive VR in rehabilitating CP children as a standalone intervention or in combination with traditional therapy. The review follows the PRISMA guidelines and includes a comprehensive search of five bibliographic databases. Two reviewers independently assess the search results, evaluate full‐text publications, and extract relevant data. The outcomes were described by the International Classification of Functioning, Disability, and Health for Children and Youth (ICF‐CY) framework. A total of 20 English‐language studies published between January 2013 and January 2023 are included in the review based on predefined inclusion and exclusion criteria. The findings demonstrate that non‐immersive VR, when used in conjunction with traditional therapy, yields positive effects on body structure and function (hand function, grip strength, and upper extremity function), activity (motor function, activities of daily life [ADL], balance), and participation (caretakers' assessment, usability, motivation, and user satisfaction) in CP children. Moreover, non‐immersive VR alone is found to be more efficient than traditional therapy in improving manual dexterity in CP children. The non‐immersive VR can be effective in rehabilitating CP children, and the review concludes by recommending future research with larger sample sizes and randomized trials to investigate further the potential benefits of non‐immersive VR in this population.
Wafer‐scale single‐crystal two‐dimensional materials for integrated optoelectronics
Authors: Feng Xin , Ma Yiran , Huang Tian , Liu Shenghong , Liu Lixin , Guo Erjuan , Liu Kailang , Li Yuan , Zhou Xing , Li Huiqiao , Zhai Tianyou 
Published: August 2024

AbstractSince the pioneering research on graphene, two‐dimensional (2D) materials have been considered as the most promising candidates to continue advancing Moore's Law, and an emerging material family, which has bred a lot of novel functional applications beyond the Si‐based integrated circuit. Unfortunately, abundant challenges in the synthesis of wafer‐scale single‐crystal (WSSC) 2D materials and their on‐chip integration technology severely hinder their commercialization road. Over the past few years, significant technique breakthroughs of WSSC 2D materials have been increasingly achieved, accordingly a comprehensive review and critical evaluation of these new advances are pressingly required. In this review article, the outstanding research progress on the synthesis of WSSC 2D materials and 2D material‐based on‐chip integration technology, including 2D materials integration, nanopatterning, electrode integration, and dielectric integration, are summarized in detail. Then, the major application prospect of different types of WSSC 2D materials in optoelectronics is discussed. Finally, a critical assessment of these advancements is given, as well as the potential challenges and opportunities in the foreseeable future.
Computing imaging in shortwave infrared bands enabled by MoTe2/Si 2D‐3D heterojunction‐based photodiode
Authors: Shi Dongfeng , Chen Jiawang , Zhu Menglei , Guo Zijun , He Zixin , Li Ming , Wu Di , Wang Yingjian , Li Liang 
Published: August 2024

AbstractBreakthroughs brought about by two‐dimensional (2D) materials in the field of photodetection have opened up new possibilities in infrared imaging. However, challenges still exist in fabricating high‐density detector arrays using such materials, which are essential for traditional imaging systems. In this study, we present a state‐of‐the‐art computing imaging system that utilizes a MoTe2/Si self‐powered photodetector coupled with flexible Hadamard modulation algorithms. This system demonstrates remarkable capability to produce high‐quality images in the shortwave infrared (SWIR) band, surpassing the capabilities of devices based on alternative material systems. The exceptional infrared imaging capability primarily stems from the MoTe2/Si photodetector's inherent features, including an ultra‐wide spectral range (265–1550 nm) and extremely high sensitivity (linear dynamic range (LDR) up to 123 dB, responsivity (R) up to 0.33 A W–1, external quantum efficiency (EQE) up to 43% and a specific detectivity (D*) exceeding 2.9 × 1011 Jones). Moreover, the imaging system demonstrates the ability to achieve high‐quality edge imaging of objects in the SWIR band (1550 nm), even in strong scattering environments and under low sampling rate conditions (sampling rate of 25%). We believe that this work will effectively advance the application scope of 2D materials in the field of computational imaging in SWIR bands.image
Epigenetic alternations in the SYP and DLG4 genes due to low‐level methylmercury exposure during neuronal differentiation in vitro
Authors: Kurita Hisaka , Masuda Haruka , Okuda Ayu , Go Suzuna , Ohuchi Kazuki , Yoshioka Hiroki , Fujimura Masatake , Hozumi Isao , Inden Masatoshi 
Published: August 2024

AbstractMethylmercury (MeHg) is an environmental toxin known to damage the central nervous system. When pregnant women ingest seafood, which may contain accumulated MeHg, fetal development may be affected. The embryonic period, a time of major epigenetic change, is susceptible to epigenetic disruptions due to chemical exposure. Therefore, understanding the molecular mechanism underlying MeHg's effects on neuronal development requires consideration of epigenetic factors. In this study, we investigated epigenetic modifications in the synaptophysin (SYP) and discs large MAGUK scaffold protein 4 (DLG4) genes. LUHMES cells were exposed to 1 nM MeHg for 6 days during days 2–8 of neural differentiation. MeHg exposure significantly reduced the number of spikes observed on day 16 of differentiation. Both mRNA and protein expression levels of SYP and DLG4 were significantly decreased by MeHg exposure. Additionally, MeHg treatment reduced acetyl histone H3 levels associated with transcriptional activity in the SYP gene while increasing histone H3 lysine 27 tri‐methylation (H3K27me3) levels related to transcriptional repression. Conversely, regarding the DLG4 gene, MeHg exposure increased H3K27me3 levels. Differential changes in DNA methylation (high and low methylation states) were observed in the SYP and DLG4 genes due to MeHg exposure depending on CpG site position. In conclusion, this study suggests that epigenetic changes, particularly histone modifications, contribute to decreased MeHg exposure‐induced SYP and DLG4 expression during neuronal differentiation.
Comparative efficacy of double plasma molecular adsorption system combined with plasma exchange versus plasma exchange in treating acute‐on‐chronic liver failure due to hepatitis B: A meta‐analysis
Authors: Zhang Le , Ma Yan , Wang Xia , Ma Li‐Na , Ma Wanlong , Ding Xiang‐Chun 
Published: August 2024

AbstractThis meta‐analysis aims to evaluate the effectiveness of the double plasma molecular adsorption system (DPMAS) in combination with plasma exchange (PE) compared to plasma exchange alone in the treatment of Acute‐on‐Chronic liver failure (LF) caused by hepatitis B. Until August 31, 2023, a comprehensive search of databases including Embase, Chinese Medical Journal Full‐text Database, China Biomedical Literature Database, Wan Fang Medical Network, PubMed, and the Cochrane Library was carried out using keywords like “liver failure,” “acute‐on‐chronic liver failure,” “PE,” “DPMAS,” and related terms. The quality of the included studies was evaluated using QUADS (quality assessment of diagnostic accuracy studies). Software Revman 5.3 was used to examine the data, while Stata 15.1 was used to run Egger's test. Following thorough screening, 452 patients who received PE alone and 429 patients who received DPMAS in addition to PE were included. Every study that was included was of a high caliber. When comparing the DPMAS plus PE group to the PE alone group, the total bilirubin reduction was considerably higher (mean difference [MD] = −49.09, 95% confidence interval [CI]: −54.84 to −43.35, p < .00001). Prothrombin activity (PTA; MD = −1.53, 95% CI: −3.29 to −0.22, p = .09), albumin (ALB; MD = −0.58, 95% CI: −1.57 to 0.41, p = .25), prothrombin time (PT; MD = −0.07, 95% CI: −1.47 to 1.34, p = .92), and platelet count (PLT; MD = −0.08, 95% CI: −1.33 to 1.66, p = .90) did not differ significantly. The improvement in international standardized ratio (INR) was significantly greater in the PE group (MD = 0.07, 95% CI (0.03, 0.10), p = .0001). When combined with DPMAS, PE has been shown to be more effective in lowering total bilirubin levels. PE can also lower INR in individuals who have hepatitis B‐related ACLF. This therapeutic strategy also lessens the need for plasma transfusions.
Single‐crystal X‐ray analysis of the diketo form of asymmetric curcuminoids and coupled with NMR insights into its β‐Keto‐enol tautomerization at ambient temperature
Authors: Cheng Yang‐Je , Lin Jyun‐Yi , Shih Tzenge‐Lien , Hsieh Chung‐Hung 
Published: August 2024

AbstractIn this study, we present a detailed analysis of the structural forms of asymmetric curcuminoids through single‐crystal X‐ray diffraction and nuclear magnetic resonance (NMR) spectroscopy. Curcuminoids substituted with electron‐withdrawing groups (Cl and Br) predominantly adopt the β‐keto‐enol form, whereas those with an OMe group exhibit both diketo and β‐keto‐enol forms. Variable‐temperature X‐ray diffraction studies confirm that the structural state of curcuminoids is influenced by temperature. Our findings also reveal that the β‐keto‐enol form is favored in acidic and neutral conditions, while the diketo form is more prevalent in basic environments. The theoretical Density Functional Theory (DFT) calculations further elucidate the energy differences between the diketo and β‐keto‐enol forms, emphasizing the significance of electronic effects and temperature on tautomeric distributions. These insights enhance our understanding of the structural dynamics of curcuminoids, with implications for their biological activity and pharmacological applications.
The added value of superb microvascular imaging for renal cortical thickness measurement in chronic kidney disease
Authors: Limpisook Poemporn , Waongenngarm Pooriput , Siripongsakun Surachate , Nuangchamnong Nannapat , Promrach Nutsurang , Thabsangthong Thananya 
Published: August 2024

AbstractPurposeThe aim of this study was to evaluate renal parenchymal thickness and renal cortical thickness measurements on brightness mode ultrasound (B‐mode US) and B‐mode US + Superb Microvascular Imaging (SMI) technique, comparing with computed tomography (CT) or magnetic resonance imaging (MRI) serving as a reference standard.MethodsRenal parenchymal thickness and renal cortical thickness measurements were obtained from B‐mode US, B‐mode US + SMI, and CT/MRI in a group of healthy subjects and a group of patients with chronic kidney disease (CKD). The mean differences and correlations of renal parenchymal thickness and renal cortical thickness were analyzed using dependent pair t‐test and Pearson's correlation, respectively.ResultsThe mean difference in renal cortical thickness measurements between B‐mode US + SMI and CT/MRI was lower than the mean difference between B‐mode US alone and CT/MRI. Additionally, renal cortical thickness measured using B‐mode US + SMI showed a stronger correlation with values obtained from CT/MRI than values measured using standard B‐mode US alone.ConclusionThe measurement of renal cortical thickness by B‐mode US + SMI is more accurate than that by B‐mode US alone.
Artificial neural network prediction of postoperative complications in papillary thyroid microcarcinoma based on preoperative ultrasonographic features
Authors: Yi Zhanxiong , He Enhui , Yang Peipei , Wang Zhixiang , Hu Xiangdong , Feng Ying 
Published: August 2024

AbstractObjectiveTo predict post‐thyroidectomy complications in papillary thyroid microcarcinoma (PTMC) patients using a deep learning model based on preoperative ultrasonographic features. This study addresses the global rise in PTMC incidence and the challenges in treatment decision‐making with high‐resolution ultrasonography.MethodThis study enrolled 1638 patients with clinically staged cN0 PTMC who received surgical treatment from 1997 to 2019 at Beijing Friendship Hospital. Deep learning model was developed using fully connected neural network. Feature selection included 1000 iterations of Bootstrap sampling and Recursive Feature Elimination (RFE) to identify the top 10 features. Data preprocessing involved normalization and imputation for missing values. SMOTE addressed class imbalance. The model was trained and tested on random data split, with performance metrics including Accuracy (ACC), Area Under the Curve (AUC), Sensitivity (SEN), and Specificity (SPE), visualized through a ROC curve and confusion matrix.ResultsThe fully connected deep neural network model demonstrated high accuracy (ACC 0.81), Area Under the Curve (AUC 0.74), sensitivity (SEN 0.65), and specificity (SPE 0.83) and visualized by ROC curve and confusion matrix. These results highlight the model's reliability and potential as an effective tool in predicting postoperative complications and assisting in clinical decision‐making for PTMC patients.ConclusionThis study highlights the potential of deep learning in enhancing medical predictions and personalized healthcare. Despite promising results, limitations include a single‐center data source and unconsidered factors like lifestyle and genetics. Future research should expand data sources, include more influencing factors, and refine algorithms to improve accuracy and applicability in thyroid cancer treatment.
The significance of assessing the umbilical cord on the placental side: A case report on fused umbilical arteries
Authors: Kaymak Didem , Dobral Arzu , Oruc Simge Berrak Beyoglu , Daglar Halil Korkut 
Published: August 2024

AbstractThis report details the case of a fetus with fused umbilical arteries (FUAs), which exhibited the presence of a single umbilical artery near the site of placental insertion, as well as normal two umbilical arteries at the fetal end of the umbilical cord. In our case, as the pregnancy progressed, there was an occurrence of late‐onset fetal growth restriction and oligohydramnios. This is a possibility that FUAs might impact the development of the fetus.
The association of the medial meniscus covering ratio with knee cartilage thickness at 15 medial compartment subregions as found by three‐dimensional analysis using MRI
Authors: Ozeki Nobutake , Koga Hideyuki , Nakamura Tomomasa , Katagiri Hiroki , Nakagawa Yusuke , Hoshino Takashi , Katakura Mai , Amemiya Masaki , Yoshihara Aritoshi , Katano Hisako , Mizuno Mitsuru , Endo Kentaro , Masumoto Jun , Sekiya Ichiro 
Published: August 2024

AbstractPurposeThe correlation of cartilage thickness measured by three‐dimensional (3D) magnetic resonance imaging (MRI) and the medial meniscal coverage ratio (MMCR), which presented pathology of the medial meniscus extrusion (MME) in 3D MRI, has not yet been elucidated. The study's purpose was to retrospectively verify whether the average cartilage thickness calculated by the automatic MRI 3D analysis system for each subregion was correlated with MMCR.MethodsA total of 60 patients underwent medial meniscus repair or high tibial osteotomy to treat their medial knee osteoarthritis. Cartilage thickness and MMCR were automatically calculated using 3D MRI software. The MMCR was defined as the ratio of the area covered by the meniscus within the medial tibial cartilage area to the total medial tibial cartilage area. The association between MMCR and the average cartilage thickness at 15 subregions in the medial femoral condyle (MFC) and medial tibial plateau (MTP) was evaluated using Spearman's rank correlation coefficient.ResultsKellgren–Lawrence grade exhibited a negative correlation with MMCR and a positive correlation with MME width. Cartilage thickness in the MTP had a moderately positive correlation with MMCR at four subregions and a weakly positive correlation at another subregion. Cartilage thickness in the MFC showed a moderately positive correlation with MMCR at five subregions and a weakly positive correlation at one subregion.ConclusionsCartilage thickness calculated by automatic MRI 3D analysis system had a positive correlation with MMCR for all subregions of the anterior and middle subregions in the MFC and for five regions of nine subregions of the anterior and middle subregions in the MTP.Level of evidenceLevel II, cross‐sectional study (diagnosis).
The impact of financial inclusion initiatives: Evidence from meta‐analysis
Authors: Biru Ashenafi , Molla Alemayehu , Ferraro Salvatore , Navon Yonatan 
Published: August 2024

AbstractDeveloping an inclusive financial system is an important policy intervention to improve livelihood and reduce poverty. Despite this, the empirical evidence on the impacts of financial inclusion remains mixed. This study reports a meta‐analysis of studies on the impact of financial inclusion. The findings show that financial inclusion outcomes reflect small, positive and statistically significant average effects on consumption, income, asset and other poverty‐related indicators. The results of meta‐regression analysis also show that financial inclusion has a significant positive effect on household consumption. We discuss some of the sources of inconsistencies in financial inclusion studies, policy implications and future research directions.
19Fluorine‐MRI Based Longitudinal Immuno‐Microenvironment‐Monitoring for Pancreatic Cancer
Authors: Reichardt Wilfried , Gewalt Tabea , Hafner Philipp , Keller Steffen J. , Chen Xun , Alrawashdeh Asma , Li Yayu , Besson Solène , Fichtner‐Feigl Stefan , von Elverfeldt Dominik , Jumaa Huda , Ruess Dietrich A. 
Published: August 2024

BackgroundPancreatic cancer has a poor prognosis. Targeting Kirsten Rat Sarcoma (KRAS) mutation and its related pathways may enhance immunotherapy efficacy. While in vivo monitoring of therapeutic response and immune cell migration remains challenging, Fluorine‐19 MRI (19F MRI) may allow noninvasive longitudinal imaging of immune cells.PurposeEvaluating the potential of 19F MRI for monitoring changes in the tumor immune microenvironment, in response to combined SHP2/MEK inhibition.Study TypePre‐clinical animal study.Animal ModelMurine genetically engineered pancreatic cancer model (N = 20, both sexes).Field Strength/Sequence9.4‐T, two‐dimensional multi‐slice Rapid Acquisition with Relaxation Enhancement sequence. Intravenous injection of 19F‐perfluorocarbon (PFC) nanoparticles.AssessmentUpon tumor detection by conventional 1H MRI screening, 19F MRI was performed in mice 24 hours after PFC nanoparticle administration. Animals were randomly assigned to four treatment groups: allosteric Src‐homology‐2‐containing protein tyrosine phosphatase 2 (SHP2) inhibitor SHP099, the mitogen‐activated extracellular signal‐regulated kinase 1/2 (MEK1/2) inhibitor Trametinib, the combination of both, or a vehicle control (4 to 6 mice each group), administered every other day per oral gavage. 1H and 19F MRI was repeated 7 days and 14 days later. Pancreatic immune cell infiltrates were analyzed by flow cytometry and multiplex immunohistofluorescence (mIHF) upon sacrifice.Statistical TestsIndependent t‐tests and one‐way analysis of variance.Results19F MRI revealed continuous decrease of PFC‐signals in tumors from vehicle controls (100%, 80%, and 74% on days 0, 7, and 14, respectively), contrasting with stable or increasing signals under KRAS‐pathway‐directed treatment. MEK inhibition showed 100%, 152%, and 84% and dual SHP2/MEK1/2 inhibition demonstrated signals of 100%, 134%, and 100% on days 0, 7, 14, respectively. mIHF analyses indicated CD11b+ macrophages/monocytes as primary contributors to the observed 19F MRI signal differences.Data Conclusion19F MRI might provide non‐invasive longitudinal estimates for abundance and spatial distribution of CD11b+ macrophages/monocytes in pancreatic cancer.Evidence Level1Technical EfficacyStage 2