bluuebunny/crossref_metadata_2025_split huggingface dataset:
From marital conflict to life satisfaction: How basic psychological need satisfaction operates—A dyadic analysis study
Authors: Koçak Aylin 
Published: August 2024

AbstractAlthough attempts have been made to untangle the possible mechanisms underlying the relationship between marital conflict and life satisfaction, the number of studies examining the possible intervening mechanisms is still limited. Therefore, guided by the self‐determination theory, this study aimed to examine the mediating role of basic psychological need satisfaction in the relationship between marital conflict and life satisfaction using a dyadic analysis method. The sample consisted of 235 female (Mage = 44.58, SD = 5.69) and male (Mage = 47.90, SD = 5.77) pairs. The Actor–Partner Interdependence Model Extended to Mediation (APIMeM) was used to examine the within and between pathways in the stated relations. Findings demonstrated actor and partner effects between need satisfaction and life satisfaction; however, females' need satisfaction was only marginally associated positively with their male partners' life satisfaction. Moreover, while males' need satisfaction was negatively related to both their own and their partners' marital conflict, females' need satisfaction was only negatively related to their marital conflict. Finally, for all pathways in the model, males' need satisfaction was supported as a full mediator between marital conflict and life satisfaction. Females' need satisfaction, on the other hand, significantly mediated the relationship between their own marital conflict and life satisfaction. The findings provide insights by elucidating the interplay between these variables in dyadic relationships and highlighting the critical importance of need satisfaction in overcoming marital challenges and enhancing partners' overall life satisfaction.
Contrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study
Authors: Feizi Alborz , DiRito Jenna R. , Richfield Owen , Stendahl John C. , Harris Matthew , Spindler Susann , Edwards Christopher M. , Lysyy Taras , Lee Shin Rong , Boutagy Nabil E. , Feher Attila , Yoo Peter , Hosgood Sarah A. , Mulligan David C. , Nicholson Michael L. , Sinusas Albert J. , Haakinson Danielle J. , Tietjen Gregory T. 
Published: August 2024

AbstractBackgroundEx vivo perfusion of transplant‐declined human organs has emerged as a promising platform to study the response of an organ to novel therapeutic strategies. However, to fully realize the capability of this platform for performing translational research in human organ pathophysiology, there is a need for robust assays to assess organ function and disease. State‐of‐the‐art research methods rely on analyses of biopsies taken during perfusion, which both damages the organ and only provides localized information. Developing non‐invasive, whole organ methods of assessment is critical to the further development of this research platform.MethodsWe use ex vivo cold infusion scanning (EXCIS) with contrast‐enhanced computed tomography (CT) to quantify perfusion in kidneys preserved ex vivo. EXCIS‐CT computes three complementary metrics for whole organ assessment: a dynamic assessment of contrast filling, a measure of vascular network anatomical structure, and a static assessment of perfusion heterogeneity.ResultsThese metrics were applied to a series of six transplant‐declined human kidneys, which demonstrated a range of anatomies and perfusion. Lastly, two transplant‐declined human kidneys were imaged before and after a 1‐h period of ex vivo normothermic perfusion (NMP). We found variable responses to NMP, with one kidney maintaining the vascular network and hemodynamics and the other showing significant changes in vessel size and spatial perfusion profile.ConclusionsEXCIS‐CT provides metrics that can be used to characterize whole organ perfusion and vascular function.
It's just a game! Effects of fantasy in a storified test on applicant reactions
Authors: Ohlms Marie L. , Melchers Klaus G. , Lievens Filip 
Published: August 2024

AbstractThere is increasing attention to storification of assessments (i.e., embedding a storyline into a non‐storified assessment) in research and practice and to gamified and game‐based assessment in general. However, there is a surprising lack of agreement and of recommendations regarding what level of fantasy of the storyline one should choose for the storification from the perspective of applicant reactions. A distinction is typically made between fantasy (e.g., fighting aliens) and realistic (e.g., workday simulations) storylines, with both choices having their advantages and disadvantages. In this study, a sample of 195 participants was shown either a storified realistic test, a storified fantasy test, or a non‐storified test. Afterwards, they rated various applicant reaction measures. Both storified assessments were rated equally positively on perceived modernity of the organization and enjoyment but the storified realistic test was superior to the storified fantasy test in terms of perceived job‐relatedness, procedural fairness, organizational attractiveness, and clarity of work activity. Thus, the level of fantasy of a storyline in a storified assessment plays an important role for applicant reaction variables, whereby the overall pattern of results showed that the storified realistic test was rated most favorably, followed by the non‐storified test, and the storified fantasy assessment.
CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma
Authors: Kumar Emil Arjun , Korfi Koorosh , Bewicke‐Copley Findlay , Close Karina , Heward James , Witzig Thomas , Leukam Michael , Ansell Stephen , Scott Jessica , Clear Andrew , Efeyan Alejo , Green Michael , Siebert Reiner , Peck Barrie , Calaminici Maria , Wang Jun , Smith Sonali , Novak Anne , Fitzgibbon Jude , Okosun Jessica 
Published: August 2024

SummaryDespite the clinical and molecular heterogeneity of follicular lymphoma (FL), there remains a lack of biomarker‐directed therapeutic approaches in routine clinical practice, with the notable exception of the EZH2 inhibitor tazemetostat in EZH2‐mutant FL. Here we examined whether gene mutation status predicts response to clinical mTOR inhibitors (mTORi) in FL, by performing targeted mutational profiling of biopsies from 21 relapsed/refractory FL patients treated with mTORi everolimus or temsirolimus within clinical trials. We observed an enrichment of mutations within the catalytic histone acetyltransferase (HAT) domain of CREBBP in mTORi‐responders, and describe distinct transcriptional characteristics and co‐occurring mutations of FL harbouring these mutations; reinforcing the growing appreciation of CREBBPHAT mutation as a key biological determinant and its promise as a therapeutic biomarker in FL.
Momelotinib: Mechanism of action, clinical, and translational science
Authors: Vlasakakis Georgios , McCabe Michael T. , Ho Yu Liu , Ferron‐Brady Geraldine , Martin Paul , Bentley Darren , Ellis Catherine , Antonysamy Mary , Visser Sandra A. G. 
Published: August 2024

AbstractMyelofibrosis is a chronic myeloproliferative disorder characterized by bone marrow fibrosis, splenomegaly, anemia, and constitutional symptoms, with a median survival of ≈6 years from diagnosis. While currently approved Janus kinase (JAK) inhibitors (ruxolitinib, fedratinib) improve splenomegaly and symptoms, most can exacerbate myelofibrosis‐related anemia, a negative prognostic factor for survival. Momelotinib is a novel JAK1/JAK2/activin A receptor type 1 (ACVR1) inhibitor approved in the US, European Union, and the UK and is the first JAK inhibitor indicated specifically for patients with myelofibrosis with anemia. Momelotinib not only addresses the splenomegaly and symptoms associated with myelofibrosis by suppressing the hyperactive JAK–STAT (signal transducer and activator of transcription) pathway but also improves anemia and reduces transfusion dependency through ACVR1 inhibition. The recommended dose of momelotinib is 200 mg orally once daily, which was established after review of safety, efficacy, pharmacokinetic, and pharmacodynamic data. Momelotinib is metabolized primarily by CYP3A4 and excreted as metabolites in feces and urine. Steady‐state maximum concentration is 479 ng/mL (CV%, 61%), with a mean AUCtau of 3288 ng.h/mL (CV%, 60%); its major metabolite, M21, is active (≈40% of pharmacological activity of parent), with a metabolite‐to‐parent AUC ratio of 1.4–2.1. This review describes momelotinib's mechanism of action, detailing how the JAK–STAT pathway is involved in myelofibrosis pathogenesis and ACVR1 inhibition decreases hepcidin, leading to improved erythropoiesis. Additionally, it summarizes the pivotal studies and data that informed the recommended dosage and risk/benefit assessment.
“The compounds for females are really commonly faked!”: Women's challenges in anabolic steroid acquisition and the place of drug checking interventions
Authors: Piatkowski Timothy , Havnes Ingrid Amalia , Kill Emma , Barratt Monica J. 
Published: August 2024

AbstractIntroductionWomen who use drugs, particularly those using anabolic‐androgenic steroids (AAS), encounter heightened social risks influenced by the legal status of AAS, varying regionally. In jurisdictions where AAS are legal, medical guidance and prescription are common, while in illegal regions, there are challenges associated with acquisition and safer usage. Therefore, we aimed to explore the experiences of women who use AAS in Australia, where these substances are criminalised, with a focus on the challenges they encounter in acquiring and using these drugs.MethodsWe focused on data from six women in a broader study interviewing 15 AAS users. The data were subjected to iterative inductive analysis, resulting in two theme‐categories.ResultsWomen who use AAS face distinct challenges in accessing reliable suppliers, with men seemingly having ‘easier’ access. Women experience this disparity as increasing their vulnerability to unsafe products, further compounded by their lack of knowledge regarding these substances. Moreover, mislabelling and counterfeiting of female‐specific AAS substances is described to further compound these risks, reflecting the participants' expressed need for enhanced intervention and quality control in the AAS market.Discussion and ConclusionsEnsuring product reliability, transparency and accountability are perceived as essential for the health and safety of women who use AAS. To address these issues, interventions should provide women with comprehensive drug checking services tailored to their health needs. ‘Steroid literacy’ must be an integral component, equipping women with knowledge to make informed decisions in the gendered AAS market.
How does oil policy uncertainty influence resource rents? New empirical evidence from Organization of the Petroleum Exporting Countries
Authors: Farooq Umar , Wen Jun , Aldawsari Salem Hamad , Tabash Mosab I. , Khudoykulov Khurshid 
Published: August 2024

AbstractThe uncertainty surrounding oil‐related policies has raised concerns about its influence on revenues derived from resource extraction activities. In this view, the current study aims to investigate the nuanced relationship between oil policy uncertainty (OPU) and resource rents, focusing on oil rents (ORTs), natural gas rents (NRTs), and total resource rents (TRT). Analyzing data spanning from 1985 to 2019 across Organization of the Petroleum Exporting Countries, various econometric models including DOLS, FMOLS, and autoregressive distributed lag are employed to assess the impact of OPU on resource rents. The empirical findings reveal a significant negative effect of heightened OPU levels on resource rents, indicating a reduction in ORT, NRT, and TRT. This negative impact underscores the deterrence of long‐term investments in oil exploration and production due to regulatory unpredictability, leading to decreased revenues from oil extraction activities. Additionally, increased OPU contributes to heightened volatility in oil prices, disrupting the stability of resource rents. Furthermore, variables such as FDI inflow, inflation rate, and banking sector development exhibit positive relationships with resource rents, emphasizing their role in bolstering revenues derived from natural resources. The study's implications highlight the necessity for policymakers to address and mitigate OPU to foster stability and sustainable revenues within resource‐driven economies. This study contributes to the existing literature by offering empirical insights into the adverse impact of OPU on resource rents.
The influence of grade retention on students' competences in Spain
Authors: Lopez‐Agudo Luis Alejandro , de Guevara Rodríguez María Ladrón , Marcenaro‐Gutierrez Oscar David 
Published: August 2024

AbstractGrade retention is at the core of the education debate in Spain, to the extent that its impact on students' competences has not been assessed beyond correlation. Because of that, in the present study, we analyse the influence of grade retention on students' competences, using more than 146,000 students from 6 PISA cycles (2003–2018) and an instrumental variable approach, in order to approach a causal influence. Our results show that repeating a grade in Spain seems to reduce students' competences between 1.5 and 1.7 standard deviations. Based on these results, we conclude that the Spanish educational authorities should find an alternative to grade retention, in order to prevent students from attaining a lower competence level due to repetition.
Efficacy of ixazomib, lenalidomide, dexamethasone regimen in daratumumab‐exposed relapsed/refractory multiple myeloma patients: A retrospective analysis
Authors: Fric Dominik , Stork Martin , Boichuk Ivanna , Sandecka Viera , Adam Zdenek , Krejci Marta , Ondrouskova Eva , Fidrichova Anna , Radova Lenka , Knechtova Zdenka , Jarosova Marie , Pour Ludek 
Published: August 2024

AbstractWe performed retrospective analysis of relapsed/refractory multiple myeloma (RRMM) patients previously exposed to daratumumab treated with ixazomib, lenalidomide, dexamethasone (IRd) regimen in real clinical practice. Our aim was to evaluate efficacy of IRd in these patients and select a subset of patients that would benefit from this treatment the most. In total, we analyzed 43 daratumumab‐exposed RRMM patients treated in our center. Minimal response or better was achieved by 53.5% of patients from the cohort. Median progression free survival (PFS) was 4.56 months (95% CI: 2.56, 8.03) and median overall survival (OS) was 28.92 months (95% CI: 5.4, NR). Duration of response (DOR) was evaluable in 28 patients and reached a median of 21.3 months (95% CI: 6.85, NR). Next, we evaluated hazard ratios (HR) for OS and PFS. There was improved OS in patients that were not‐triple refractory or worse (HR = 0.39, 95%Cl (0.14; 1.10), p = .07) and in patients, that had less than three previous lines of treatment (LOT) (HR = 0.13, 95%Cl (0.03; 0.6) p = .003). Similar to OS, there was improved PFS in patients, that were not triple‐refractory or worse (HR = 0.52, 95%Cl (0.25; 1.10), p = .08). We concluded, that the best survival benefit for RRMM patients pretreated with daratumumab to IRd regimen was observed in patients that were not triple‐refractory and had less than three previous lines of treatment (LOT). The DOR in these patients was 21.3 months (95% CI: 6.85, NR).
The effect of visual speech cues on neural tracking of speech in 10‐month‐old infants
Authors: Çetinçelik Melis , Jordan‐Barros Antonia , Rowland Caroline F. , Snijders Tineke M. 
Published: August 2024

AbstractWhile infants' sensitivity to visual speech cues and the benefit of these cues have been well‐established by behavioural studies, there is little evidence on the effect of visual speech cues on infants' neural processing of continuous auditory speech. In this study, we investigated whether visual speech cues, such as the movements of the lips, jaw, and larynx, facilitate infants' neural speech tracking. Ten‐month‐old Dutch‐learning infants watched videos of a speaker reciting passages in infant‐directed speech while electroencephalography (EEG) was recorded. In the videos, either the full face of the speaker was displayed or the speaker's mouth and jaw were masked with a block, obstructing the visual speech cues. To assess neural tracking, speech‐brain coherence (SBC) was calculated, focusing particularly on the stress and syllabic rates (1–1.75 and 2.5–3.5 Hz respectively in our stimuli). First, overall, SBC was compared to surrogate data, and then, differences in SBC in the two conditions were tested at the frequencies of interest. Our results indicated that infants show significant tracking at both stress and syllabic rates. However, no differences were identified between the two conditions, meaning that infants' neural tracking was not modulated further by the presence of visual speech cues. Furthermore, we demonstrated that infants' neural tracking of low‐frequency information is related to their subsequent vocabulary development at 18 months. Overall, this study provides evidence that infants' neural tracking of speech is not necessarily impaired when visual speech cues are not fully visible and that neural tracking may be a potential mechanism in successful language acquisition.
Behavioural changes in young ovariectomized mice via GPR30‐dependent serotonergic nervous system
Authors: Furukawa Megumi , Izumo Nobuo , Aoki Ryoken , Nagashima Daichi , Ishibashi Yukiko , Matsuzaki Hideo 
Published: August 2024

AbstractFluctuations in estradiol levels at each stage of life in women are considered one of the causes of mental diseases through their effects on the central nervous system. During menopause, a decrease in estradiol levels has been reported to affect the serotonin nervous system and induce depression‐like and anxiety symptoms. However, the regulation of brain and behaviour during childhood and adolescence is poorly understood. Moreover, the role of oestrogen receptors α and β in the regulation of the serotonergic nervous system has been reported, but little is known about the involvement of G protein‐coupled receptor 30. Therefore, in this study, we used an ovariectomized childhood mouse model to analyse behaviour and investigate the effects on the serotonin nervous system. We showed that ovariectomy surgery at 4 weeks of age, which is the weaning period, induced a decrease in spontaneous locomotor activity during the active period and a preference for novel mice over familiar mice in the three‐chamber social test at 10 weeks of age. In addition, the administration of G‐1, a protein‐coupled receptor 30 agonist, to ovariectomized mice suppressed spontaneous locomotor activity and the preference for novel mice. Furthermore, we demonstrated that childhood ovariectomy induces increased tryptophan hydroxylase gene expression in the raphe nucleus and increased serotonin release in the amygdaloid nucleus, and administration of G‐1 ameliorated these effects. Our study suggests that G protein‐coupled receptor 30‐mediated regulation of serotonin synthesis is involved in changes in activity and social‐cognitive behaviour due to decreased estradiol levels during childhood.
Trust region based chaotic search for solving multi‐objective optimization problems
Authors: El‐Shorbagy M. A. 
Published: August 2024

AbstractA numerical optimization technique used to address nonlinear programming problems is the trust region (TR) method. TR uses a quadratic model, which may represent the function adequately, to create a neighbourhood around the current best solution as a trust region in each step, rather than searching for the original function's objective solution. This allows the method to determine the next local optimum. The TR technique has been utilized by numerous researchers to tackle multi‐objective optimization problems (MOOPs). But there is not any publication that discusses the issue of applying a chaotic search (CS) with the TR algorithm for solving multi‐objective (MO) problems. From this motivation, the main contribution of this study is to introduce trust‐region (TR) technique based on chaotic search (CS) for solving MOOPs. First, the reference point interactive approach is used to convert MOOP to a single objective optimization problem (SOOP). The search space is then randomly initialized with a set of initial points. Second, in order to supply locations on the Pareto boundary, the TR method solves the SOOP. Finally, all points on the Pareto frontier are obtained using CS. A range of MO benchmark problems have demonstrated the efficiency of the proposed algorithm (TR based CS) in generating Pareto optimum sets for MOOPs. Furthermore, a demonstration of the suggested algorithm's ability to resolve real‐world applications is provided through a practical implementation of the algorithm to improve an abrasive water‐jet machining process (AWJM).
Investigating the effect of polymer additives on the rheology of SiC/clay paste for use in Direct Ink Writing method
Authors: Nikookar Amir Mohammad , Ghaffari Seyed Amir , Sarpoolaky Hossein 
Published: August 2024

AbstractIn this study, we investigated the impact of polyethylene glycol, sodium carboxymethyl cellulose, and polyvinyl alcohol on the rheological behavior, printability, and mechanical/physical properties of 3D‐printed scaffolds for high‐temperature applications using SiC/clay ceramic paste. Employing the Direct Ink Writing method, varying concentrations of each polymer (PEG: 2.5%–10% weight, CMC: .6%–1.8% weight, PVA: .25%–1% weight) were incorporated into the composition. The resulting SiC/clay paste, with adjusted additive content, was used to 3D‐print scaffold structures through Direct Ink Writing. Sintering of clay‐bonded SiC samples were carried out at 1300°C for 1 h in an ambient atmosphere. The research revealed that altering the additive amounts significantly influenced the rheological behavior, mechanical properties, and physical characteristics of the printed specimens. Notably, the ideal properties with additive concentrations (10% wt PEG, 1% wt PVA, and .6% CMC) were identified, providing the best outcomes in terms of printability and firing results. High density samples with 2.09, 1.93, and 1.79 g/cm3, high compression strength of 20.82, 14.5 and 12.53 MPa with 32.26%, 42.5%, and 52.63% open porosity for samples containing PVA, CMC, and PEG modifiers were obtained, respectively. Additionally, the study led to the development of a high solid loading printable paste with an 80% weight.
Association between bone age maturity and childhood adiposity
Authors: Chávez‐Vázquez Ana Gabriela , Klünder‐Klünder Miguel , Lopez‐Gonzalez Desiree , Vilchis‐Gil Jenny , Miranda‐Lora América Liliana 
Published: August 2024

SummaryBackgroundEvidence shows that overweight and obesity are associated with advanced bone age (BA).ObjectiveTo analyse the effect of adiposity on BA among Mexican children.MethodsThis cross‐sectional study included 902 children (5–18 years old). Anthropometric measurements, dual‐energy X‐ray absorptiometry (DXA) and automated hand X‐ray‐based BA measurements were obtained. BA curves of children stratified by sex and age were created based on nutritional status. We also calculated odds ratios for advanced BA associated with the body mass index (BMI), waist/height ratio and adiposity estimated using DXA (total and truncal fat mass).ResultsParticipants with overweight/obesity by BMI (SDS ≥1) advanced earlier in BA than did normal weight participants (6.0 vs. 12.0 years in boys and 6.0 vs. 10.3 in girls, p < 0.01); similarly, participants with a greater body fat percentage (SDS ≥1) exhibited earlier advanced BA (7.5 vs. 10.0 years in boys and 6.0 vs. 9.6 in girls, p < 0.01). Differences were also observed according to the waist/height ratio and truncal fat. Children with a BMI or DXA SDS ≥1 had greater odds of presenting an advanced BA of more than 1 year (OR 1.79–3.55, p < 0.05).ConclusionsIncreased adiposity in children, mainly in boys, is associated with advanced BA at earlier ages.