bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Study of Porous High‐Entropy Oxides as Low‐Temperature Catalysts for CO2 Methanation
Authors: Knorpp Amy J. , Mielniczuk Monika , Nikolic Marin , Vogel Alexander , Figi Renato , Schreiner Claudia , Borgschulte Andreas , Stuer Michael 
Published: August 2024

AbstractHigh‐entropy oxides (HEOs) are an emerging class of materials whose compositional complexity has garnered attention because of their tailorable chemistries and unique properties arising from extreme configurational entropy. Solid‐state methods are often employed to synthesize HEOs, but such methods result in poor material properties for catalytic processes, leaving HEOs less studied for catalysis. Here we utilize different wet‐synthesis strategies to produce porous HEOs and investigate their performance in heterogeneous CO2 hydrogenation to methane. Specifically, HEOs were synthesized using hydrothermal, co‐precipitation, and solvothermal methods, resulting in different morphologies like platelets or spheres. Of the tested materials, HEOs with 2‐D platelets derived from hydrothermally‐synthesized high‐entropy layered double hydroxides had superior catalytic performance, especially in low‐temperature regimes (<300 °C). K‐edge XANES indicated that metallic sites (Ni0‐Co0) were formed during the reaction, and these metallic sites are dispersed into the HEO matrix which is confirmed by STEM/elemental mapping. This facile synthesis approach allows for realized synergy between the metallic sites and the HEO support, leading to superior performance for CO2 methanation compared to low‐entropy counterparts. Finally, this study illustrates how HEOs offer new avenues of tailorability in terms of the interplay between support, active site and reaction temperatures for heterogeneous catalysis.
Prevalence of Fabry disease in patients with chronic pain: Lessons from the DOUFAB and DOUFABIS studies
Authors: Angelini Chloé , Bar Claire , Baudier Marie Pierre , Fergelot Patricia , Lancelot Gwenaëlle , Rooryck Caroline , Germain Dominique P. , Jabbour Firas , Blanchet Anne‐Sophie , Cauchie Alexandre , Sarrazin Elisabeth , Bellance Rémi , Lefaucheur Jean‐Pascal , Bismuth Julie , Ranque‐Garnier Stéphanie , Corand Virginie , Coupry Isabelle , Goizet Cyril ,   The DOUFABIS Consortium
Published: August 2024

AbstractBackgroundFabry disease (FD) is a rare X‐linked lysosomal disorder caused by alpha‐galactosidase deficiency consecutive to a pathogenic variant in the GLA gene. Age at onset is highly variable, with a wide clinical spectrum including frequent renal, cardiac, skin and nervous system manifestations. Since pain can be an indicator of underlying FD, we wanted to estimate the prevalence of FD in a population of chronic pain patients.MethodsTwo studies, DOUFAB and DOUFABIS, were carried out in expert centers for chronic pain to assess the prevalence of FD by measuring alpha galactosidase A activity in men and analysing the GLA gene in women.ResultsAnalysis of 893 patients, essentially adults, led to the diagnosis of FD in one female patient, now treated with enzyme replacement therapy.ConclusionsThe prevalence of FD is estimated about 1/1000 in our population of men and women suffering from various chronic pain. This is nearly the prevalence of FD observed in other previously screened high‐risk populations with renal failure.SignificanceAlthough a systematic search for FD does not seem relevant in the context of unexplained chronic pain in adults, a positive family history of FD or the presence of additional FD related organ features must lead to consider this rare disease diagnosis. Therefore, pain specialists need to be aware of main features of FD, including pain characteristics.
How Microstructures, Oxide Layers, and Charge Transfer Reactions Influence Double Layer Capacitances. Part 2: Equivalent Circuit Models
Authors: Schalenbach Maximilian , Raijmakers Luc , Tempel Hermann , Eichel Rüdiger‐A. 
Published: August 2024

ABSTRACTIn the first part of this study, double layer (DL) capacitances of plane and porous electrodes were related to electrochemical active surface areas based on electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) measurements. Here, these measured data are described with equivalent circuit models (ECMs), aiming to critically assess the ambiguity, reliability, and pitfalls of the parametrization of physicochemical mechanisms. For microstructures and porous electrodes, the resistive–capacitive contributions of DL in combination with resistively damped currents in pores are discussed to require the complexity of convoluted transmission line ECMs. With these ECMs, the frequency‐dependencies of the capacitances of porous electrodes are elucidated. Detailed EIS or CV data‐based reconstructions of complex microstructures are discussed as impossible due to the blending of individual structural features and the related loss of information. Microstructures in combination with charge transfer reactions and weakly conducting parts require parameter‐rich ECMs for an accurate physicochemical description of all physicochemical mechanisms contributing to the response. Nevertheless, the data of such a complex electrode in the form of an oxidized titanium electrode are fitted by an oversimplistic ECM, showing how easily unphysical parameterizations can be obtained with ECM‐based impedance analysis. In summary, trends in how microstructures, charge transfer resistances and oxide layers can influence EIS and CV data are shown, while awareness for the overinterpretation of ECM‐analysis is raised.
Nonlinear static analysis of masonry structures with mortar joints and cracking units by optimization‐based rigid block models
Authors: Portioli Francesco P. A. , Lourenço Paulo B. 
Published: August 2024

AbstractA rigid block model with elasto‐plastic softening interfaces is developed for nonlinear static analysis of masonry structures subject to monotonic loading. Cracking, crushing, and shear failures are taken into account at interfaces, following a simple micro‐modeling approach. An optimization‐based formulation is used for the solution of the equation systems governing the behavior of the rigid block assemblage. A simple incremental solution procedure is implemented to take into account the material softening behavior and the effects of large displacements on equilibrium conditions. The interface models are validated against tension and shear tests on bi‐block prisms from the literature. Applications to numerical and experimental out‐of‐plane loaded masonry walls as well as to circular arches with mortar joints are presented to evaluate the effects of tensile strength and the accuracy of the developed model against responses involving P‐Δ effects. Comparisons with experimental tests on shear walls also involving cracking of the units in the failure mechanisms are finally reported to discuss the potentialities and limitations of the proposed modeling approach.
Enhancing immunomodulation in cyclophosphamide‐induced immunosuppressed mice through targeted modulation of butyrate‐producing gut microbiota via oral administration of astragalus polysaccharides
Authors: Rong XinQian , Shu QingLong 
Published: August 2024

AbstractAstragalus polysaccharide is one of the most extensively studied traditional Chinese medicinal polysaccharides because of its immunomodulatory activity and has attracted considerable attention. Existing evidence suggests that its potential immunomodulatory mechanism is related to the modulation of intestinal microbiota. However, current research methods on the gut microbiota mainly focus on 16S rRNA sequencing, providing limited evidence of specific changes in functional bacterial groups in the intestine. Butyrate is a class of short‐chain fatty acids among the microbial metabolites in the gut and is most closely associated with immunomodulatory activity. Thus, in this study, we extracted and purified a polysaccharide from astragalus composed of a main chain of →4)‐α‐D‐Glcp‐(1 → and →4,6)‐α‐D‐Glcp‐(1→, with side chains of →6)‐α‐D‐Glcp‐(1→ and aggregated arabinose, and investigated the changes in butyrate‐producing bacterial groups in mice during the immunomodulation process of astragalus polysaccharide, using two butyrate‐producing bacterial‐specific primers. The results showed that oral administration of astragalus polysaccharide significantly increased butyrate production in the mouse intestine, restoring the disrupted butyrate‐producing bacterial abundance and diversity caused by immunosuppression. In conclusion, our study provides the first evidence of the targeted modulation of the butyrate‐producing gut microbiota by astragalus polysaccharide, offering insights into its pharmacological activity.
Sustainable medical tourism in the global competitive environment: The case of Cyprus
Authors: Ntais Christos , Stavrou Polidefkis , Fanourgiakis John , Talias Michael A. , Kontodimopoulos Nikolaos 
Published: August 2024

AbstractBackgroundThe aim of this study is to examine the perceptions of Cypriot medical tourism experts regarding the phenomenon of medical tourism, as well as to emphasise the benefits and opportunities for Cyprus to become a highly competitive global healthcare destination.MethodsA Delphi study was conducted in Cyprus, with the participation of 20 experts in the field of medical tourism. At first, 20 experts took part in semi‐structured interviews. Based on their feedback provided during that phase, a structured questionnaire was drawn up and completed, addressing a wide variety of medical tourism‐related issues, such as benefits and losses from the development of medical tourism in Cyprus, advantages and disadvantages of Cyprus in attracting international patients, the key elements of a medium‐ to long‐term strategic plan for the development of medical tourism in Cyprus, the role of the public and private sector and the importance of international accreditation of private and public hospitals.ResultsCyprus appears to have some very favourable qualities when it comes to its listing as a competitive destination for medical travellers. Undeniably, the growth of medical tourism improves all sectors of the economy and society, but the healthcare industry is the one that benefits most. On the opposite end, medical tourism could potentially impact the access of local people to healthcare services. No clear answers were given by the expert respondents on the need for international accreditation of healthcare providers in Cyprus.ConclusionThe competent authorities should promote Cyprus to international markets as a medical tourism destination of choice, upgrading the quality of healthcare services it provides having due regard in parallel to any potential impacts to the access of local population to the healthcare system.
Correlations of mixed convection in a double lid‐driven shallow rectangular cavity: The case of non‐Newtonian power‐law fluids
Authors: Louaraychi A. , Lamsaadi M. 
Published: August 2024

AbstractThis work provides an analytical and numerical assessment, complete with correlations, of mixed convection in a double lid‐driven shallow rectangular enclosure, which confines non‐Newtonian fluids of the Ostwald–de Waele type and which a uniform thermal flux heats. The finite volume method with the SIMPLER algorithm is the numerical method used to solve the governing partial differential equations along with the boundary conditions, where the parallel flow concept is the analytical approach. In the limits of the explored values of the governing parameters of this study, which are the Rayleigh number, the Peclet number, and the behavior index, the results obtained by these approaches appear to be in good harmony. On the basis of the results obtained by these approaches, we established helpful correlating relations between the governing parameters to realize the contribution of mixed convection to heat transfer. This leads to the finding that the ratio Ra/Pe2+n is the mixed convection parameter, which is the key to distinguishing the three convective flow modes. On the basis of this parameter, which allows the transition from one regime to another, it is possible to identify the zones that designate the predominance of natural, forced, and mixed convection. The limits of these latter depend on the behavior index, n, which is diversified from 0.6 to 1.4 to account for shear thinning (0 < n < 1, low apparent viscosity, high fluid flow, and high heat transfer rate), Newtonian (n = 1), and shear thickening (n > 1, high apparent viscosity, slow fluid flow, and low heat transfer rate) fluids. On the other hand, the study presents and interprets the influences of the steering factors on heat transfer and fluid flow.
Personalized approach to malignant struma ovarii: Insights from a web‐based machine learning tool
Authors: Alshwayyat Sakhr , Abo‐elnour Dina Essam , Dabash Tala Yaser , Alshwayyat Tala Abdulsalam , Alabbasi Marah , Alshwayyat Mustafa , Irsheidat Kinda Akram 
Published: August 2024

AbstractObjectivesMalignant struma ovarii (MSO) is a rare ovarian tumor characterized by mature thyroid tissue. The diverse symptoms and uncommon nature of MSO can create difficulties in its diagnosis and treatment. This study aimed to analyze data and use machine learning methods to understand the prognostic factors and potential management strategies for MSO.MethodsIn this retrospective cohort, the Surveillance, Epidemiology, and End Results (SEER) database provided the data used for this study's analysis. To identify the prognostic variables, we conducted Cox regression analysis and constructed prognostic models using five machine learning algorithms to predict the 5‐year survival. A validation method incorporating the area under the curve of the receiver operating characteristic curve was used to validate the accuracy and reliability of the machine learning models. We also investigated the role of multiple therapeutic options using the Kaplan–Meier survival analysis.ResultsThe study population comprised 329 patients. Multivariate Cox regression analysis revealed that older age, unmarried status, chemotherapy, and the total number of tumors in patients were poor prognostic factors. Machine learning models revealed that the multilayer perceptron accurately predicted outcomes, followed by the random forest classifier, gradient boosting classifier, K‐nearest neighbors, and logistic regression models. The factors that contributed the most were age, marital status, and the total number of tumors in the patients.ConclusionThe present study offers a comprehensive approach for the treatment and prognosis assessment of patients with MSO. The machine learning models we have developed serve as a practical, personalized tool to aid in clinical decision‐making processes.
A case of double‐negative prostate cancer with BRCA2 mutation and high tumor mutation burden treated sequentially with olaparib and pembrolizumab
Authors: Tanaka Hiroki , Yoshida Soichiro , Aoyama Satoru , Ikeda Sadakatsu , Kunieda Junko , Ohashi Kenichi , Fukuda Shohei , Waseda Yuma , Tanaka Hajime , Fujii Yasuhisa 
Published: August 2024

IntroductionDouble‐negative prostate cancer, an androgen receptor–independent prostate cancer without features of neuroendocrine tumors, is refractory to treatment but could be an ideal candidate for individualized treatment.Case presentationAn 85‐year‐old patient with metastatic castration‐resistant prostate cancer without prostate‐specific antigen progression presented with local recurrence and liver and lung metastases 6 months after orchiectomy and apalutamide. A liver tumor biopsy led to a diagnosis of double‐negative prostate cancer. FoundationOne® CDx showed BRCA2 mutation and high tumor mutation burden. Olaparib and pembrolizumab were administered sequentially, and the patient responded to each treatment for 5 months until radiographic progression.ConclusionSequential use of olaparib and pembrolizumab may be effective for double‐negative prostate cancer with BRCA2 mutations and high tumor mutation burden.
Multi‐color two‐laser super‐resolution structured illumination microscopy for the visualization of multi‐organelle in living cells
Authors: Hu Xuejuan , Tan Yadan , Huang Yujie , Ye Jianze , Liang Yifei , Yang Xiaokun , Wang Hengliang , Cheng Zihao , Wang Lihu , Liu Shiqian , Li Minfei , He Zhengdi , Gao Qianding , Zhong Jingli 
Published: August 2024

AbstractIn this study, we introduced a novel dual‐laser multi‐color imaging system. Integrated with a multi‐channel filter wheel, this system compared three spectral decontamination algorithms (nonnegative matrix factorization [NMF], RCAN, and PICASSO) showcasing its efficacy in achieving four‐color imaging with only two laser sources. Combined with a reliable image reconstruction algorithm, the spatial resolution of four channels super‐resolution four‐color images reached 130, 125, 133, and 132 nm, respectively. Lipid droplets, mitochondria, lysosomes, and nuclei from the mouse hepatocytes (AML12), human neuroblastoma cells (SH‐SY5Y), mouse hippocampal neuronal cells (HT‐22), and immortalized murine bone marrow‐derived macrophages were imaged. At the same time, the chromatin condensation, nuclear contraction, DNA fragmentation, apoptotic body formation, as well as the fusion of Mito and Lyso involved in mitochondrial autophagy were observed in HT‐22 and SH‐SY5Y cells suffering oxidative stress. Our multi‐color SIM imaging system establishes a powerful platform for dynamic organelle studies and other high‐resolution investigations in live cells.
Work is the best medicine: A qualitative analysis of posttraumatic stress disorder and supported employment
Authors: Lu Weili , Bates Francine , Waynor William , Bazan Carolyn , Yanos Philip T. , Gao Carol , Librera LueAnn , Giacobbe Giovanna , Schultz Emily , Rogers Krista 
Published: August 2024

AbstractCo‐occurring posttraumatic stress disorder (PTSD) negatively impacts employment outcomes for individuals with serious mental health conditions (SMHCs). This study examined how employment might help individuals manage PTSD. Sixty‐eight employed individuals with SMHCs and co‐occurring PTSD responded to two open‐ended questions focused on how work impacted the management of PTSD symptoms and their perceived need for support from a job coach. Findings revealed themes about benefits of work on PTSD symptom management and types of provider support desired. Study implications are discussed.
Celiac artery stenosis and its impact on postoperative outcomes following pancreaticoduodenectomy: An institutional analysis
Authors: Pasha Shamsher A. , Khalid Abdullah , Arena Julia , Alizadeh Ahmadreza , Levine Jeffrey , Demyan Lyudmyla , Deutsch Gary , Weiss Matthew J. , Newman Elliot , Melis Marcovalerio 
Published: August 2024

AbstractBackgroundThe detection of a stenotic celiac artery (CA) typically mandates intraoperative revascularization during pancreaticoduodenectomy (PD) to preserve liver perfusion. The impact of CA stenosis on postoperative outcomes is unclear. This study evaluates whether CA stenosis (CAS) is associated with increased postoperative complications.MethodsWe conducted a retrospective analysis of PD patients from February 2014 to February 2022. Preoperative imaging assessed the CA lumen, categorizing it as patent, <50%, or ≥50% stenosis. Patients with narrowed SMA were excluded. Complications were categorized using the Clavien‐Dindo system, and statistical analyses identified outcome differences.ResultsWe included 427 patients in the study. Of these, 52 had CAS, and 311 had no‐vessel stenosis (NVS). The median age of the CAS and NVS groups was 68 and 65 years, respectively. Postoperatively, 17.6% of patients with CAS exhibited delayed gastric emptying (DGE) versus 25.3% in the NVS group. Postoperative pancreatic fistula (POPF) was found in 13.5% of patients with CAS, compared with 23.7% without stenosis. The median length of hospital stay was shorter for patients with CAS (9 days) than for those with CAS (12 days). Severity‐based classifications indicated higher complications in the no stenosis group and a 33.0% readmission rate within 30 days compared with 21.2% in CAS patients. However, none of these differences were statistically significant.ConclusionsCritical stenosis of the CA does not significantly affect postoperative outcomes following PD, suggesting preoperative correction of the narrowed CA may not be necessary. Further research is needed to confirm these findings.
Incidental negative emotions and tourist destination preferences: A choice model during lockdown
Authors: Zhou Lingxu , Qiu Richard T. R. , Wang Sha , Liu Anyu , Wang Lin 
Published: August 2024

AbstractIncidental and discrete emotions can influence tourist decision‐making and their preferences for destinations with different types of attractions and activities. In this explorative study, we apply a choice model and the cognitive appraisal theory of emotion to examine the influence of those negative emotions that emerged during Australia's lockdown on tourists' anticipated destination preferences. We find that negative emotions were influenced by both pre‐lockdown emotions and lockdown conditions. Negative emotions exert a significant impact on tourists' selection of destinations and influence their attitudes toward social distancing measures. Travel motivations and gender also affect tourist preferences. Finally, we address the theoretical implications of this study regarding the impact of incidental emotions on travel preferences and make practical suggestions to practitioners on providing targeted products and adjusting management and marketing strategies.
Health‐related quality of life for children with anterior cruciate ligament deficiency: Ensuring content validity of the new KIDS‐KNEES‐ACL questionnaire
Authors: Hansen Christian Fugl , Brodersen John Brandt , Krogsgaard Michael Rindom 
Published: August 2024

AbstractPurposeThe existing knee‐specific pediatric patient‐reported outcome measures (PROMs) lack content and construct validity for children with anterior cruciate ligament (ACL) injury. This impairs their accuracy which can lead to false interpretations of data and inaccurate clinical guidelines. The purpose of this study was to develop a content‐valid PROM for children with an ACL injury.MethodsThe process adhered to the COnsensus‐based Standards for the selection of health Measurement INstruments guidelines for PROM development. Informants were children with ACL deficiency and sampled based on age, sex, and treatment. Semistructured interviews were conducted exploring themes within the International Classification of Functioning, Disability and Health model. Interviews continued beyond data saturation. By thematic analysis and by probing items from the adult PROM ‘KNEES‐ACL’, new themes and items emerged. Content coverage, relevance and understandability were continuously evaluated. All interviews were recorded and transcribed verbatim. The NVivo 12 software was used for data analysis and coding of items.ResultsA PROM of 60 items across nine subscales was formed. From cognitive interviews, 19 new items emerged. Forty‐one of 55 items from KNEES‐ACL were endorsed as relevant; however, all required rewording to ensure understandability. Substantial differences in the psychosocial impact between adults and children were observed. The children experienced a more considerable negative psychosocial impact caused by a loss of participation in sports, lower self‐confidence and loss of social networks. This resulted in four new domains. The physical issues were similar to adults, with few exceptions.ConclusionThe ‘KIDS‐KNEES‐ACL’ 1.0 (qualitative version) was developed. This version will be subjected to psychometric analysis, resulting in adequate measurement properties of the final KIDS‐KNEES‐ACL 2.0. As the only adequate pediatric ACL‐specific PROM, its use in clinical trials and databases will enhance PROM data quality, and strengthen clinical guidelines and thus the treatment of children with ACL injury.Level of EvidenceNot applicable