bluuebunny/crossref_metadata_2025_split huggingface dataset:
T-Scan III System Diagnostic Tool for Digital Occlusal Analysis in Orthodontics – a Modern Approach
Authors: Trpevska Vesna , Kovacevska Gordana , Benedeti Alberto , Jordanov Bozidar 
Published: December 2014

Abstract

Introduction: This systematic literature review was performed to establish the mechanism, methodology, characteristics, clinical application and opportunities of the T-Scan III System as a diagnostic tool for digital occlusal analysis in different fields of dentistry, precisely in orthodontics.

Methods: Searching of electronic databases, using MEDLINE and PubMed, hand searching of relevant key journals, and screening of reference lists of included studies with no language restriction was performed. Publications providing statistically examined data were included for systematic review. Results: Twenty potentially relevant Randomized Controlled Trials (RCTs) were identified. Only ten met the inclusion criteria. The literature demonstrates that using digital occlusal analysis with T-Scan III System in orthodontics has significant advantage with regard to the capability of measuring occlusal parameters in static positions and during dynamic of the mandible.

Conclusion: Within the scope of this systematic review, there is evidence to support that T-Scan system is rapid and accurate in identifying the distribution of the tooth contacts and it shows great promise as a clinical diagnostic screening device for occlusion and for improving the occlusion after various dental treatments. Additional clinical studies are required to advance the indication filed of this system. Importance of using digital occlusal T-Scan analysis in orthodontics deserves further investigation.
Baseline CD4+ T-cell Count and Cardiovascular Risk Factors Predict the Evolution of Cognitive Performance During 2-Year follow-up in HIV-Infected Patients
Authors: Ciccarelli Nicoletta , Grima Pierfrancesco , Fabbiani Massimiliano , Baldonero Eleonora , Borghetti Alberto , Milanini Benedetta , Limiti Silio , Colafigli Manuela , Tamburrini Enrica , Cauda Roberto , De Luca Andrea , Giambenedetto Simona Di 
Published: December 2014

Background The aim of our study was to better understand the dynamics between cardiovascular risk factors and immunological parameters in the evolution of cognitive performance in HIV+ patients. Methods We conducted a prospective longitudinal study, consecutively enrolling asymptomatic HIV+ subjects during routine outpatient visits at two clinical centres. At baseline and after 2 years, all patients underwent a comprehensive neuropsychological battery. Common carotid intima-media thickness (cIMT) was also measured. Results A total of 150 patients completed the study (77% males, median age 46 years, 20% with past AIDS-defining events, 95% on cART, 88% with HIV-RNA<50 copies/ml). After a 2-year follow-up, there was no difference in the proportion of patients with cognitive impairment (32% versus 33% at baseline; P=1.00). However, a significantly worse memory performance was observed (z score mean change -0.51, sd 1.05; P=0.001). At multivariate analysis, baseline dyslipidaemia (OR 2.7, 95% CI 1.1, 7.1; P=0.037) showed a significant association with a higher risk of memory impairment at 2-year follow-up, while higher baseline CD4+ T-cell count (OR 0.80 per 100 cells/ml higher; 95% CI 0.66, 0.97; P=0.026) was found to be a protective factor, adjusting for the presence of a memory impairment at baseline. When the analysis was restricted to patients who did not change antiretroviral therapy during the study period ( n=109), baseline cIMT (OR 14.6 per 0.1 mm higher; 95% CI 1.1, 189.9; P=0.041) also emerged as an independent risk factor for memory impairment at 2-year follow-up. Conclusions Immunological parameters and cardiovascular risk factors are independently associated with the evolution of cognitive status in HIV+ patients.
Écran, anamorphose et construction d'un espace transitionnel
Authors: Rappaport Clémentine 
Published: December 2014

Ce cas clinique illustre la première année de traitement psychothérapique d’un enfant de 2 ans et demi atteint de troubles du spectre autistique sévères. La thérapie se déroule en présence de la mère. Le chemin parcouru avec Mathys et sa mère durant les séances est un voyage partagé. La découverte fortuite de l’utilisation d’un écran de smartphone en séance par l’enfant ouvre des questions théoriques sur la schize de l’œil et du regard chez un enfant autiste.
La synchronie et le mamanais dans les films familiaux peuvent-ils nous éclairer sur la dynamique interactive précoce des bébés futurs autistes avec leurs parents ?
Authors: Saint-Georges Catherine 
Published: December 2014

L’autisme se résume-t-il à un déficit irrémédiable d’une zone du cerveau ou bien est-il le fruit d’un processus impliquant en proportion variable « équipement » du bébé et interaction ? La connaissance des premiers processus qui conduisent au tableau autistique caractérisé est cruciale, tant pour comprendre la psychopathologie autistique que pour intervenir précocement. Les recherches cliniques et théoriques de Marie-Christine Laznik l’ont conduite à s’intéresser à la voix comme objet primaire de la pulsion, capable d’enchanter même un bébé autiste, à la condition qu’elle traduise la joie suscitée par ce bébé (mamanais) . Cette hypothèse nous introduit au cœur de la dynamique interactive des bébés autistes avec leur care-giver. L’étude des films familiaux permet d’appréhender et d’objectiver les premières compétences du bébé mais aussi les premières interactions, leur réciprocité (ou synchronie), et l’évolution de cette dynamique interactive. Les bébés autistes manquent très précocement d’intérêt pour l’autre, et notamment sa voix. Cela retentira sans doute sur leur intersubjectivité en construction. En réponse, les parents confrontés à ces bébés s’adaptent en s’efforçant de les solliciter plus. Reste à savoir s’ils peuvent encore prendre du plaisir avec ces bébés qui semblent si indifférents ?
Des droits et des aspi rations...À propos du livre de Josef Schovanec, Je suis à l'Est !
Authors: Bentata Hervé 
Published: December 2014

À partir du témoignage de Josef Schovanec, un « savant et autiste » comme il se déclare, l’auteur tente d’en reprendre les idées forces qui permettent, par leur prise de hauteur, de sortir l’autisme d’une vision purement déficitaire et de handicap, comme d’une vision de pure maladie, tout en redressant de nombreux préjugés concernant par exemple l’absence d’humour des autistes ou bien la toxicité de la psychanalyse. Nous revoilà recentrés sur les vraies questions : droits et aspirations des personnes avec autismes, et non plus querelles de clocher.
Antigen Recognition in the Islets Changes with Progression of Autoimmune Islet Infiltration
Authors: Lindsay Robin S. , Corbin Kaitlin , Mahne Ashley , Levitt Bonnie E. , Gebert Matthew J. , Wigton Eric J. , Bradley Brenda J. , Haskins Kathryn , Jacobelli Jordan , Tang Qizhi , Krummel Matthew F. , Friedman Rachel S. 
Published: December 2014

Abstract
In type 1 diabetes, the pancreatic islets are an important site for therapeutic intervention because immune infiltration of the islets is well established at diagnosis. Therefore, understanding the events that underlie the continued progression of the autoimmune response and islet destruction is critical. Islet infiltration and destruction is an asynchronous process, making it important to analyze the disease process on a single islet basis. To understand how T cell stimulation evolves through the process of islet infiltration, we analyzed the dynamics of T cell movement and interactions within individual islets of spontaneously autoimmune NOD mice. Using both intravital and explanted two-photon islet imaging, we defined a correlation between increased islet infiltration and increased T cell motility. Early T cell arrest was Ag dependent and due, at least in part, to Ag recognition through sustained interactions with CD11c+ APCs. As islet infiltration progressed, T cell motility became Ag independent, with a loss of T cell arrest and sustained interactions with CD11c+ APCs. These studies suggest that the autoimmune T cell response in the islets may be temporarily dampened during the course of islet infiltration and disease progression.
Direct and Indirect Effects of Immune and Central Nervous System–Resident Cells on Human Oligodendrocyte Progenitor Cell Differentiation
Authors: Moore Craig S. , Cui Qiao-Ling , Warsi Nebras M. , Durafourt Bryce A. , Zorko Nika , Owen David R. , Antel Jack P. , Bar-Or Amit 
Published: December 2014

AbstractIn multiple sclerosis, successful remyelination within the injured CNS is largely dependent on the survival and differentiation of oligodendrocyte progenitor cells. During inflammatory injury, oligodendrocytes and oligodendrocyte progenitor cells within lesion sites are exposed to secreted products derived from both infiltrating immune cell subsets and CNS-resident cells. Such products may be considered either proinflammatory or anti-inflammatory and have the potential to contribute to both injury and repair processes. Within the CNS, astrocytes also contribute significantly to oligodendrocyte biology during development and following inflammatory injury. The overall objective of the current study was to determine how functionally distinct proinflammatory and anti-inflammatory human immune cell subsets, implicated in multiple sclerosis, can directly and/or indirectly (via astrocytes) impact human oligodendrocyte progenitor cell survival and differentiation. Proinflammatory T cell (Th1/Th17) and M1-polarized myeloid cell supernatants had a direct cytotoxic effect on human A2B5+ neural progenitors, resulting in decreased O4+ and GalC+ oligodendrocyte lineage cells. Astrocyte-conditioned media collected from astrocytes pre-exposed to the same proinflammatory supernatants also resulted in decreased oligodendrocyte progenitor cell differentiation without an apparent increase in cell death and was mediated through astrocyte-derived CXCL10, yet this decrease in differentiation was not observed in the more differentiated oligodendrocytes. Th2 and M2 macrophage or microglia supernatants had neither a direct nor an indirect impact on oligodendrocyte progenitor cell differentiation. We conclude that proinflammatory immune cell responses can directly and indirectly (through astrocytes) impact the fate of immature oligodendrocyte-lineage cells, with oligodendrocyte progenitor cells more vulnerable to injury compared with mature oligodendrocytes.
Chronic Lymphocytic Leukemia Cells Express CD38 in Response to Th1 Cell–Derived IFN-γ by a T-bet–Dependent Mechanism
Authors: Bürgler Simone , Gimeno Aleix , Parente-Ribes Anna , Wang Dong , Os Audun , Devereux Stephen , Jebsen Peter , Bogen Bjarne , Tjønnfjord Geir E. , Munthe Ludvig A. 
Published: December 2014

Abstract
Chronic lymphocytic leukemia (CLL) is a B cell malignancy associated with increased levels of inflammatory cytokines. Similarly, expression of CD38 on CLL cells correlates with CLL cell survival and proliferation, but the mechanisms that regulate CD38 expression and inflammatory cytokines remain unclear. We have recently demonstrated that patients have CLL-specific Th cells that support CLL proliferation. In this article, we show that CLL cells attract such Th cells, thereby establishing an Ag-dependent collaboration. Blocking experiments performed in vitro as wells as in vivo, using a xenograft model, revealed that secretion of IFN-γ was a major mechanism by which CLL-specific Th cells increased CD38 on CLL cells. The expression of the transcription factor T-bet in peripheral blood CLL cells significantly correlated with CD38 expression, and transient transfection of CLL cells with T-bet resulted in T-bethiCD38hi cells. Finally, chromatin immunoprecipitation experiments revealed that T-bet can bind to regulatory regions of the CD38 gene. These data suggest that CLL cells attract CLL-specific Th cells and initiate a positive feedback loop with upregulation of T-bet, CD38, and type 1 chemokines allowing further recruitment of Th cells and increased type 1 cytokine secretion. This insight provides a cellular and molecular mechanism that links the inflammatory signature observed in CLL pathogenesis with CD38 expression and aggressive disease and suggests that targeting the IFN-γ/IFN-γR/JAK/STAT/T-bet/CD38 pathway could play a role in the therapy of CLL.
Cutting Edge: IL-1α Is a Crucial Danger Signal Triggering Acute Myocardial Inflammation during Myocardial Infarction
Authors: Lugrin Jérôme , Parapanov Roumen , Rosenblatt-Velin Nathalie , Rignault-Clerc Stéphanie , Feihl François , Waeber Bernard , Müller Olivier , Vergely Catherine , Zeller Marianne , Tardivel Aubry , Schneider Pascal , Pacher Pal , Liaudet Lucas 
Published: December 2014

Abstract
Myocardial infarction (MI) induces a sterile inflammatory response that contributes to adverse cardiac remodeling. The initiating mechanisms of this response remain incompletely defined. We found that necrotic cardiomyocytes released a heat-labile proinflammatory signal activating MAPKs and NF-κB in cardiac fibroblasts, with secondary production of cytokines. This response was abolished in Myd88−/− fibroblasts but was unaffected in nlrp3-deficient fibroblasts. Despite MyD88 dependency, the response was TLR independent, as explored in TLR reporter cells, pointing to a contribution of the IL-1 pathway. Indeed, necrotic cardiomyocytes released IL-1α, but not IL-1β, and the immune activation of cardiac fibroblasts was abrogated by an IL-1R antagonist and an IL-1α–blocking Ab. Moreover, immune responses triggered by necrotic Il1a−/− cardiomyocytes were markedly reduced. In vivo, mice exposed to MI released IL-1α in the plasma, and postischemic inflammation was attenuated in Il1a−/− mice. Thus, our findings identify IL-1α as a crucial early danger signal triggering post-MI inflammation.
Chronic Lymphocytic Leukemia: A Paradigm of Innate Immune Cross-Tolerance
Authors: Jurado-Camino Teresa , Córdoba Raúl , Esteban-Burgos Laura , Hernández-Jiménez Enrique , Toledano Victor , Hernandez-Rivas Jose-Angel , Ruiz-Sainz Elena , Cobo Teresa , Siliceo María , Perez de Diego Rebeca , Belda Cristobal , Cubillos-Zapata Carolina , López-Collazo Eduardo 
Published: December 2014

Abstract
Infections are a significant cause of morbidity and mortality in patients with chronic lymphocytic leukemia (CLL). The pathogenesis of infections is multifactorial and includes hypogammaglobulinemia, conventional therapy with alkylating drugs, and recently, purine analogs and mAb-associated T cells. Patients without these risk factors also suffer from infections, although the mechanism remains unknown. In a cohort of 70 patients with CLL, we demonstrated that their monocytes were locked into a refractory state and were unable to mount a classic inflammatory response to pathogens. In addition, they exhibited the primary features of endotoxin tolerance, including low cytokine production, high phagocytic activity, and impaired Ag presentation. The involvement of miR-146a in this phenomenon was suspected. We found miR-146a target genes, such as IRAK1 and TRAF6, were manifestly downregulated. Our study provides a new explanation for infections in patients with CLL and describes a cross-tolerance between endotoxins and tumors.
Le potentiel d’offre et de demande de services médicaux dans la langue de communautés minoritaires : où se situe le français en Colombie-Britannique?
Authors: Giguère Louis , Conway Brian 
Published: December 2014

Une étude comparative du potentiel de services médicaux dans les langues minoritaires de Colombie-Britannique révèle que des médecins non-francophones parlant français génèrent une retombée linguistique qui amplifie l’offre potentielle de services de santé et de services sociaux en français de façon dramatique. Ce mécanisme structurant s’appliquerait aux autres professions de la santé et des services sociaux, partout au Canada et il serait plus prononcé plus le contexte est minoritaire. Les communautés francophones doivent faire plus pour identifier, engager et outiller les professionnels et professionnelles « francophiles » et elles doivent élaborer une logique d’équité innovatrice pour dégager le potentiel d’offre de services de santé et de services sociaux en français dans un contexte multilingue.
Une semaine dans la vie de camarades (1976) : manifeste cinématographique de la contre-culture québécoise1
Authors: Robert Marc-André 
Published: December 2014

En avril 1975 s’ouvre la Rencontre internationale de la contre-culture (RIC) de Montréal. Événement phare de la contre-culture québécoise, elle donne lieu à la production d’un long-métrage documentaire de quatre heures empruntant à l’esthétique du cinéma direct : Une semaine dans la vie de camarades (1976), des cinéastes Jean Gagné et Serge Gagné, deux acteurs de premier plan de la mouvance contre-culturelle au Québec. Portrait social et politique de la culture québécoise, ce film propose une série d’entrevues avec des « travailleurs culturels » à travers un voyage aux quatre coins du Québec. Critique de la culture institutionnalisée des années 1970, Une semaine dans la vie de camarades explore les différentes manifestations culturelles populaires en sol québécois. À partir d’une analyse historique des représentations de la contre-culture dans ce film, cet article vise à comprendre les composantes du discours politique associé à ce phénomène. En ressort la prédominance d’une prise de parole collective dans l’espace public. Manifeste à l’endroit des pouvoirs politique et économique, elle expose les clivages entre le peuple et les élites en regard à la culture.
CRÔNICA DE EVENTOS - VII SEMINÁRIO ANPTUR 2010
Authors: Wada Elizabeth Kyoko , Gastal Susana de Araújo 
Published: December 2014

O VII Seminário ANPTUR 2010 foi realizado em 20 e 21 de setembro de 2010 e discutiu o tema Ética: Produção e Difusão da Pesquisa em Turismo. O objetivo principal foi o de disseminar os resultados de pesquisas concluídas ou em andamento como contribuição ao avanço do conhecimento científico do Turismo e áreas afins. Além disso, teve o propósito de reunir a comunidade científica da área para análise e discussão das questões éticas implicadas na produção e divulgação da pesquisa, para que o crescimento e consolidação acadêmica do campo do Turismo, Hospitalidade, Lazer e área afins venha acompanhado da necessária seriedade e profundidade em termos teóricos e metodológicos bem como pelo respeito para com os pares. Houve 245 participantes, sendo a maioria (62,5%) de autores de trabalhos, portanto pesquisadores, mestres, doutores, docentes e/ou discentes de programas de pós-graduação stricto sensu. Todos os coordenadores dos Programas filiados à ANPTUR estavam presentes ou se fizeram representar. Estiveram representadas 75 Instituições e Entidades, de 24 Estados Brasileiros, além do Distrito Federal, bem como 8 instituições do exterior, de 7 países diferentes. A sétima edição do Seminário ANPTUR foi marcada pelo esforço de organização e estruturação do evento quanto ao seu caráter científico, a partir de um trabalho conjunto da Diretora Executiva da Associação e também de todos os seus membros efetivos e associados. Os resultados obtidos demonstram que a comunidade científica em Turismo já adota uma postura científica, crítica e reflexiva no desenvolvimento das pesquisas, as quais vêm contribuindo ao avanço do conhecimento científico e suas aplicações na realidade turística brasileira, priorizando a sustentabilidade, a responsabilidade social, a interdisciplinaridade e a ética.
RELATO DO I SEMINÁRIO INTERNACIONAL DE ESTUDOS CRÍTICOS EM TURISMO, NATAL/RN (BRASIL)
Authors: Leal Sérgio Rodrigues 
Published: December 2014

Síntese e conclusões do I Seminário Internacional de Estudos Críticos em Turismo, promovido pela Universidade Federal do Rio Grande do Norte e realizado em Natal, nos dias 24 e 25 de março de 2011. O evento, uma realização do Grupo de Pesquisas em Estudos Críticos em Turismo – ESCRITUR, do Programa de Pós-Graduação em Turismo – PPGTUR, contou com a presença de renomados pesquisadores do Brasil e do exterior. Com mais de 100 participantes de seis diferentes estados brasileiros, o Seminário foi dividido em quatro momentos – três mesas redondas e uma reunião do ESCRITUR, aberta a todos os presentes, como ouvintes, e aos professores pesquisadores, que puderam compartilhar suas experiências.
In Situ Detection of Integrin Ligands
Authors: Kiyozumi Daiji , Sato‐Nishiuchi Ryoko , Sekiguchi Kiyotoshi 
Published: December 2014

AbstractIntegrins are cell surface receptors for cell adhesion. Integrin‐mediated cell adhesion regulates various cellular processes, including cell survival, migration, proliferation, and differentiation. In vivo, ligands for integrins are immobilized within extracellular matrices, insoluble sheet‐like or fibrous supramolecular complexes that associate with or surround cells. To better understand the molecular basis of integrin‐mediated regulation of cellular behavior in vivo, it is of critical importance to collect information regarding the activities as well as spatial distributions of integrin ligands in situ. This unit describes a protocol for detecting the spatial distribution of the complement of integrin ligands in situ by overlaying soluble recombinant integrins. © 2014 by John Wiley & Sons, Inc.
Tracking major storms from microseismic and hydroacoustic observations on the seafloor
Authors: Davy Céline , Barruol Guilhem , Fontaine Fabrice R. , Sigloch Karin , Stutzmann Eléonore 
Published: December 2014

AbstractOcean wave activity excites seismic waves that propagate through the solid earth, known as microseismic noise. Here we use a network of 57 ocean bottom seismometers (OBS) deployed around La Réunion Island in the southwest Indian Ocean to investigate the noise generated in the secondary microseismic band as a tropical cyclone moved over the network. Spectral and polarization analyses show that microseisms strongly increase in the 0.1–0.35 Hz frequency band as the cyclone approaches and that this noise is composed of both compressional and surface waves, confirming theoretical predictions. We infer the location of maximum noise amplitude in space and time and show that it roughly coincides with the location of maximum ocean wave interactions. Although this analysis was retrospectively performed, microseisms recorded on the seafloor can be considered a novel source of information for future real‐time tracking and monitoring of major storms, complementing atmospheric, oceanographic, and satellite observations.