bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innately low D2 receptor availability is associated with high novelty-seeking and enhanced behavioural sensitization to amphetamine
Authors: Tournier Benjamin B. , Steimer Thierry , Millet Philippe , Moulin-Sallanon Marcelle , Vallet Philippe , Ibañez Vicente , Ginovart Nathalie 
Published: April 2013

Abstract
High novelty-seeking has been related to an increased risk for developing addiction, but the neurobiological mechanism underlying this relationship is unclear. We investigated whether differences in dopamine (DA) D2/3-receptor (D2/3R) function underlie phenotypic divergence in novelty-seeking and vulnerability to addiction. Measures of D2/3R availability using the D2R-preferring antagonist [18F]Fallypride, and the D3R-preferring agonist [3H]-(+)-PHNO and of DA-related gene expression and behaviours were used to characterize DA signalling in Roman high- (RHA) and low-avoidance (RLA) rats, which respectively display high and low behavioural responsiveness both to novelty and psychostimulant exposure. When compared to RLA rats, high novelty-responding RHAs had lower levels of D2R, but not D3R, binding and mRNA in substantia nigra/ventral tegmental area (SN/VTA) and showed behavioural evidence of D2-autoreceptor subsensitivity. RHA rats also showed a higher expression of the tyrosine hydroxylase gene in SN/VTA, higher levels of extracellular DA in striatum and augmentation of the DA-releasing effects of amphetamine (Amph), suggesting hyperfunctioning of midbrain DA neurons. RHA rats also exhibited lower availabilities and functional sensitivity of D2R, but not D3R, in striatum, which were inversely correlated with individual scores of novelty-seeking, which, in turn, predicted the magnitude of Amph-induced behavioural sensitization. These results indicate that innately low levels of D2R in SN/VTA and striatum, whether they are a cause or consequence of the concomitantly observed elevated DA tone, result in a specific pattern of DA signalling that may subserve novelty-seeking and vulnerability to drug use. This suggests that D2R deficits in SN/VTA and striatum could both constitute neurochemical markers of an addiction-prone phenotype.
BNIP3 acts as transcriptional repressor of death receptor-5 expression and prevents TRAIL-induced cell death in gliomas
Authors: Burton T R , Henson E S , Azad M B , Brown M , Eisenstat D D , Gibson S B 
Published: April 2013

AbstractGlioblastoma multiforme (GBM) is the most common and malignant brain tumor, and current treatment modalities such as surgical resection, adjuvant radiotherapy and temozolomide (TMZ) chemotherapy are ineffective. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a novel cancer therapeutic agent for GBM because of its capability of inducing apoptosis in glioma cells. Unfortunately, the majority of glioma cells are resistant to TRAIL-induced apoptosis. The Bcl-2 nineteen kilodalton interacting protein (BNIP3) is a pro-cell death BH3-only member of the Bcl-2 family that is one of the highest expressed genes in hypoxic regions of GBM tumors. We previously found that BNIP3 is localized to the nucleus in GBM tumors and suppresses cell death in glioma cells. Herein, we have discovered when BNIP3 nuclear expression is knockdown in glioma cell lines and in normal mouse astrocytes, TRAIL and its death receptor, death receptor-5 (DR5) expression is increased. In addition, when nuclear BNIP3 expression is increased, the amount of TRAIL-induced apoptosis is reduced. Using a streptavidin pull-down assay, we found that BNIP3 binds to the DR5 promoter and nuclear BNIP3 binds to the DR5 promoter. Furthermore, nuclear BNIP3 expression in GBM tumors correlates with decreased DR5 expression. Taken together, we have discovered a novel transcriptional repression function for BNIP3 conferring a TRAIL resistance in glioma cells.
Temporal metatranscriptomic patterning in phototrophic Chloroflexi inhabiting a microbial mat in a geothermal spring
Authors: Klatt Christian G , Liu Zhenfeng , Ludwig Marcus , Kühl Michael , Jensen Sheila I , Bryant Donald A , Ward David M 
Published: April 2013

Abstract
Filamentous anoxygenic phototrophs (FAPs) are abundant members of microbial mat communities inhabiting neutral and alkaline geothermal springs. Natural populations of FAPs related to Chloroflexus spp. and Roseiflexus spp. have been well characterized in Mushroom Spring, where they occur with unicellular cyanobacteria related to Synechococcus spp. strains A and B′. Metatranscriptomic sequencing was applied to the microbial community to determine how FAPs regulate their gene expression in response to fluctuating environmental conditions and resource availability over a diel period. Transcripts for genes involved in the biosynthesis of bacteriochlorophylls (BChls) and photosynthetic reaction centers were much more abundant at night. Both Roseiflexus spp. and Chloroflexus spp. expressed key genes involved in the 3-hydroxypropionate (3-OHP) carbon dioxide fixation bi-cycle during the day, when these FAPs have been thought to perform primarily photoheterotrophic and/or aerobic chemoorganotrophic metabolism. The expression of genes for the synthesis and degradation of storage polymers, including glycogen, polyhydroxyalkanoates and wax esters, suggests that FAPs produce and utilize these compounds at different times during the diel cycle. We summarize these results in a proposed conceptual model for temporal changes in central carbon metabolism and energy production of FAPs living in a natural environment. The model proposes that, at night, Chloroflexus spp. and Roseiflexus spp. synthesize BChl, components of the photosynthetic apparatus, polyhydroxyalkanoates and wax esters in concert with fermentation of glycogen. It further proposes that, in daytime, polyhydroxyalkanoates and wax esters are degraded and used as carbon and electron reserves to support photomixotrophy via the 3-OHP bi-cycle.
Exploring nucleo-cytoplasmic large DNA viruses in Tara Oceans microbial metagenomes
Authors: Hingamp Pascal , Grimsley Nigel , Acinas Silvia G , Clerissi Camille , Subirana Lucie , Poulain Julie , Ferrera Isabel , Sarmento Hugo , Villar Emilie , Lima-Mendez Gipsi , Faust Karoline , Sunagawa Shinichi , Claverie Jean-Michel , Moreau Hervé , Desdevises Yves , Bork Peer , Raes Jeroen , de Vargas Colomban , Karsenti Eric , Kandels-Lewis Stefanie , Jaillon Olivier , Not Fabrice , Pesant Stéphane , Wincker Patrick , Ogata Hiroyuki 
Published: April 2013

AbstractNucleo-cytoplasmic large DNA viruses (NCLDVs) constitute a group of eukaryotic viruses that can have crucial ecological roles in the sea by accelerating the turnover of their unicellular hosts or by causing diseases in animals. To better characterize the diversity, abundance and biogeography of marine NCLDVs, we analyzed 17 metagenomes derived from microbial samples (0.2–1.6 μm size range) collected during the Tara Oceans Expedition. The sample set includes ecosystems under-represented in previous studies, such as the Arabian Sea oxygen minimum zone (OMZ) and Indian Ocean lagoons. By combining computationally derived relative abundance and direct prokaryote cell counts, the abundance of NCLDVs was found to be in the order of 104–105 genomes ml−1 for the samples from the photic zone and 102–103 genomes ml−1 for the OMZ. The Megaviridae and Phycodnaviridae dominated the NCLDV populations in the metagenomes, although most of the reads classified in these families showed large divergence from known viral genomes. Our taxon co-occurrence analysis revealed a potential association between viruses of the Megaviridae family and eukaryotes related to oomycetes. In support of this predicted association, we identified six cases of lateral gene transfer between Megaviridae and oomycetes. Our results suggest that marine NCLDVs probably outnumber eukaryotic organisms in the photic layer (per given water mass) and that metagenomic sequence analyses promise to shed new light on the biodiversity of marine viruses and their interactions with potential hosts.
Effect of Fe to P concentration ratio on structures, crystallization behavior, and magnetic properties in (Fe0.79+xP0.1−xC0.04B0.04Si0.03)99Cu1 alloys
Authors: Zhang Mingxiao , Wang Anding , Yang Weiming , Shen Baolong 
Published: April 2013

The effect of Fe to P concentration ratio on structures, crystallization behavior, and magnetic properties in (Fe0.79+xP0.1−xC0.04B0.04Si0.03)99Cu1 alloys was investigated. The increase of Fe to P concentration ratio changes the structure and crystallization process of as-quenched ribbon. Nanocrystalline alloys with excellent soft magnetic properties were synthesized upon annealing the as-quenched ribbon with primary crystals. The (Fe0.84P0.05C0.04B0.04Si0.03)99Cu1 nanocrystalline alloy exhibits excellent magnetic properties, such as high saturation magnetic flux density of 1.74 T, low coercivity of 4.9 A/m, high effective permeability of 22 900 (at 1 kHz), low core loss of 3.1 W/kg at 1.0 T and 400 Hz, and 8.9 W/kg at 1.0 T and 1 kHz, respectively.
OKVAR-Boost: a novel boosting algorithm to infer nonlinear dynamics and interactions in gene regulatory networks
Authors: Lim Néhémy , Şenbabaoğlu Yasin , Michailidis George , d’Alché-Buc Florence 
Published: April 2013

Abstract
Motivation: Reverse engineering of gene regulatory networks remains a central challenge in computational systems biology, despite recent advances facilitated by benchmark in silico challenges that have aided in calibrating their performance. A number of approaches using either perturbation (knock-out) or wild-type time-series data have appeared in the literature addressing this problem, with the latter using linear temporal models. Nonlinear dynamical models are particularly appropriate for this inference task, given the generation mechanism of the time-series data. In this study, we introduce a novel nonlinear autoregressive model based on operator-valued kernels that simultaneously learns the model parameters, as well as the network structure.
Results: A flexible boosting algorithm (OKVAR-Boost) that shares features from L2-boosting and randomization-based algorithms is developed to perform the tasks of parameter learning and network inference for the proposed model. Specifically, at each boosting iteration, a regularized Operator-valued Kernel-based Vector AutoRegressive model (OKVAR) is trained on a random subnetwork. The final model consists of an ensemble of such models. The empirical estimation of the ensemble model’s Jacobian matrix provides an estimation of the network structure. The performance of the proposed algorithm is first evaluated on a number of benchmark datasets from the DREAM3 challenge and then on real datasets related to the In vivo Reverse-Engineering and Modeling Assessment (IRMA) and T-cell networks. The high-quality results obtained strongly indicate that it outperforms existing approaches.
Availability: The OKVAR-Boost Matlab code is available as the archive: http://amis-group.fr/sourcecode-okvar-boost/OKVARBoost-v1.0.zip.
Contact: florence.dalche@ibisc.univ-evry.fr
Supplementary information: Supplementary data are available at Bioinformatics online.
Galectin‐3 and left ventricular reverse remodelling after surgical mitral valve repair
Authors: Kortekaas Kirsten A. , Hoogslag Georgette E. , de Boer Rudolf A. , Dokter Martin M. , Versteegh Michel I.M. , Braun Jerry , Marsan Nina Ajmone , Verwey Hariette F. , Delgado Victoria , Schalij Martin J. , Klautz Robert J.M. 
Published: April 2013

AimsMitral valve repair in patients with functional mitral regurgitation (FMR) has been associated with beneficial left ventricular (LV) reverse remodelling. Recently, galectin‐3 emerged as a marker of myocardial inflammation and fibrosis which may influence LV remodelling after surgery. The aim of the current study was to evaluate the association between pre‐operative galectin‐3 levels and LV reverse remodelling in heart failure patients with significant FMR who underwent mitral valve repair.Methods and resultsIn total, 42 heart failure patients (66 ± 10 years, 69% male) were evaluated. Plasma galectin‐3 levels were assessed pre‐operatively. Two‐dimensional echocardiographic parameters were measured at baseline, and at 6 and 12 months after surgery. LV reverse remodelling was defined as a decrease in LV end‐systolic volume ≥15% at 6 months follow‐up. In total, 57% of the patients showed LV reverse remodelling. Patients with LV reverse remodelling showed significantly lower pre‐operative galectin‐3 levels (17.5 ± 5.6 vs. 23.7 ± 9.9 ng/mL, P = 0.009) compared with patients without LV reverse remodelling. In addition, patients with galectin‐3 ≤18.2 ng/mL had a six‐fold higher probability of showing LV reverse remodelling after surgery as compared with patients with levels >18.2 ng/mL (odds ratio 6.58, 95% confidence interval 1.32–33.33, P = 0.02).ConclusionHigh pre‐operative plasma galectin‐3 is independently associated with the absence of LV reverse remodelling after mitral valve repair. Galectin‐3 may be useful to identify heart failure patients who will need additional treatment to obtain beneficial LV reverse remodelling.
Employers’ use of older workers in the recession
Authors: Beck Vanessa 
Published: April 2013

PurposeThe purpose of this paper is to explore the degree to which there have been changes during the recession in the behaviour of employers with regards to their employment of older workers. The paper aims to show that there has been substantial change since the last recession and that there are, potentially, significant developments still occurring.Design/methodology/approachA small group of employers from a range of sectors were interviewed twice, once at the outset of the (first) recession and once towards its end.FindingsThe situation for older workers in employment is better than in previous recessions, mainly because employers are less likely to resort to redundancies for workers of all ages. Instead, a range of flexible working options are being utilised, including flexible retirement and adjustments to work processes. In the main the flexibility was instituted and controlled by the organisations. Employers are looking for alternative strategies to deal with a shift in control over the retirement process as a result of the abolishment of the default retirement age.Research limitations/implicationsThe research was undertaken with a small sample, which has implications for the generalizability of the results. Although it would be difficult to further investigate the developments of employer behaviour during the recession, the long‐term implications and the effects of the recession, in particular on older workers, are yet to emerge.Originality/valueThe paper shows a new development in dealing with older workers during a recession.
Unemployment benefits and immigration: evidence from the EU
Authors: Giulietti Corrado , Guzi Martin , Kahanec Martin , Zimmermann Klaus F. 
Published: April 2013

PurposeEconomic theory predicts that unemployment benefits may increase expected income and reduce its volatility, thereby attracting immigrants to countries which implement such programs. This article aims to explore whether and how changes in countries’ unemployment benefit spending (UBS) affect immigration.Design/methodology/approachData are collected for 19 European countries over the period 1993‐2008. The relationship between immigration flows and UBS is first tested using the OLS technique. Instrumental variable (IV) and generalised method of moments (GMM) are then used to address reverse causality.FindingsWhile the OLS estimates suggest the existence of a moderate within‐country welfare magnet effect for the inflows of non‐EU immigrants, the IV approach reveals that the impact is substantially smaller and statistically insignificant when GMM techniques are implemented.Research limitations/implicationsSince information on the immigrants’ country of origin is not available, it is not possible to exclude that for immigrants coming from certain areas, unemployment benefits constitute a strong incentive to immigrate. This hypothesis awaits further research, once detailed data is available.Originality/valueThis paper complements previous literature on immigration and welfare by exploring the endogenous nature of welfare spending. The empirical results provide insights into the interaction between immigration and welfare policies.
Did we learn everything we need to know in school?
Authors: Yarbrough Landry Amy , Hearld Larry R. 
Published: April 2013

PurposeThe purpose of this study is to examine the prevalence of different workplace learning models in healthcare organizations and examine whether these learning styles and activities differ across hierarchical level.Design/methodology/approachResults of a survey of US healthcare executives and executive‐track employees were analyzed (n=492). The survey asked for information on workplace learning style, hierarchical position, and workplace learning opportunities.FindingsEmployees at all levels of the organization report learning in a variety of ways in the workplace, including through transmission, experience, communities of practice, competence, and activity. However, employees at lower hierarchical levels report fewer workplace learning opportunities than those at higher levels.Research limitations/implicationsThe study utilizes cross‐sectional data on healthcare executives who are relatively homogenous with regard to race and gender.Practical implicationsThe results of the study are positive in that a variety of workplace learning opportunities are available to executives and executive‐track employees. However, placing more emphasis on the development of director and manager level employees would further enhance the talent pool for executive level leadership in US hospitals.Originality/valueThe study demonstrates differences in learning styles and opportunities for learning across hierarchical level.
Marketing innovation: a resource‐based view of international and local firms
Authors: Gupta Suraksha , Malhotra Naresh 
Published: April 2013

PurposeThe purpose of this paper is to conceptualize a model for fostering innovation in marketing by virtue of the competitiveness that is an outcome of the collaboration between international and local firms working together in emerging markets.Design/methodology/approachThe authors use the case of an international brand and local firms in an emerging economy to illustrate and support the proposed framework.FindingsThe extant literature on competitiveness advocates the fit between business partners in association based on mutual value creation. This paper adopts a resource‐based view to support this approach. It contributes to knowledge about emerging markets by reflecting on the benefits gained by both international firms and local firms that are based in emerging markets as partners in association for business purposes.Practical implicationsThe study draws on managerial practices and existing literature to develop a conceptual framework that explains how a resource‐based association drives individual competitiveness, and how the integration of the competitiveness of both partners facilitates innovation in marketing.Originality/valueThis study uses a resource‐based view to explain the relationship between an international brand and its resellers in emerging markets. It contributes to the business‐to‐business marketing literature that discusses innovation as an important outcome of collaboration between international firms and their local business customer firms in emerging markets.
Strategic re‐structuring by born‐globals using outward and inward‐oriented activity
Authors: Freeman Susan , Deligonul Seyda , Cavusgil Tamer 
Published: April 2013

PurposeCurrent conceptualizations of born‐globals lack a full theoretical explanation of strategic re‐structuring through the use of outward and inward‐oriented activity and the processes of de‐internationalization and re‐internationalization. Strategy and internationalization processes are created by entrepreneurial behaviour. If one wants to understand various international behaviours and strategic changes in firms one needs to focus on entrepreneurs – individual managers. The purpose of this paper is to unify the theoretical framework on born‐globals by addressing two questions. How do managers move through the de‐internationalization (exit) to re‐internationalization (re‐entry) process? How do they choose their patterns of internationalization?Design/methodology/approachTo address these research gaps, this study draws on 26 in‐depth interviews with senior managers across nine Australian born‐globals.FindingsMoving between outward and inward‐oriented activity as they de‐internationalize and re‐internationalize is used as proactive strategic re‐structuring by born‐global managers for survival during periods of global economic decline or changing competitive conditions.Originality/valueThis study provides new theoretical insights where the entrepreneur is central to the internationalization process and provides practical implications for those involved in international business and marketing.
Service orientation and dynamic capabilities in Chinese companies
Authors: Fearon Colm , Yang Jian , McLaughlin Heather , Duysters Geert M. 
Published: April 2013

PurposeThe purpose of this paper is to discuss and reflect upon some of the major (quality) issues concerning supply chain management (SCM) for Chinese companies.Design/methodology/approachThe authors draw upon the literature, especially the theoretical perspectives of service orientation and dynamic capabilities, develop a macro‐analysis of SCM issues within a conceptual framework and posit ideas for further research. Discussion and reflection of interview findings is interwoven with the literature and on‐going case study analysis.FindingsIn conjunction with the conceptual framework, the influence of government, improving relationships throughGuanxiand developing overall logistics capacity are identified as important dynamic capabilities for Chinese companies. Specific SCM issues such as: the role of distributors; regional supply networks; and information sharing are also identified and discussed. The authors suggest ideas for further research based on the discussion presented.Research limitations/implicationsGiven the relatively small number of qualitative SCM studies in recent years concerning China, an exploratory discussion and reflection of key issues from a macro‐analytical perspective is important. However, no empirical findings, propositions, or hypotheses were developed as part of the current thought‐piece. Nevertheless, the insight gained from the conceptual framework and ideas posited are useful for developing a future research agenda.Originality/valueThe paper has been written in response to calls for a wider understanding and reflection of the quality issues associated with the development of SCM in China.
An attributional perspective of aggression in organizations
Authors: Brees Jeremy R. , Mackey Jeremy , Martinko Mark J. 
Published: April 2013

PurposeThis paper emphasizes that employee attributional processing is a vital element in understanding employee aggression in organizations. The purpose of this paper is to summarize attributional perspectives and integrate recent theoretical advances into a comprehensive model.Design/methodology/approachThe paper achieved its objectives by reviewing and integrating research and theories on aggression, cognitive processing, and attribution processes to explain how employee aggression unfolds in the workplace. Propositions are suggested.FindingsIt was found that early conceptualizations proposing that employee attributions and attribution styles would play important and significant roles in predicting employee aggression were supported by recent research enabling theoretical advancements.Originality/valueOver the last 15 years, research advances show how attributions influence employee aggression. This paper integrates recent theoretical advances with prior empirical evidence and provides a comprehensive model exhibiting how attributions influence aggression in the workplace.