bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of polyethylene and polyethylene/C60 nanocomposites modified with organic peroxide
Authors: Wan Dong , Xing Haiping , Liu Feng , Wang Lu , Wang Yujie , Tan Haiying , Jiang Zhiwei , Tang Tao 
Published: November 2012

AbstractPolyethylene (PE)/fullerene C60 nanocomposites, and PE samples for comparison in the presence of 0.1 wt % and 0.3 wt % 2, 5‐dimethyl‐2, 5(tert‐butylperoxy) hexane peroxide (DHBP) were prepared by melt mixing. FTIR characterization showed that reactive C60 could be grafted onto PE chains via a radical mechanism. As a result, the dispersion state of C60 was improved, and the chain extension reaction of PE macroradicals and final topological structures were largely influenced. Linear viscoelastic response of PE and PE/C60 nanocomposites containing the same content of peroxide showed much difference. Furthermore, the results of dynamic time sweep tests demonstrated that the addition of C60 could accelerate chain extension reaction. The presence of C60 could largely improve the thermal stability of PE due to the radical scavenging nature of C60. However, the crystallization behavior, melting behavior and mechanical properties of both PE and PE/C60 samples were mainly determined by the content of peroxide. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Efficient Electroluminescence from Excimers of 1,3,6,8‐Tetrakis(3,5‐dimethylphenyl)pyrene
Authors: Chang Zhengfeng , Ye Shanghui , He Bairong , Bei Zirong , Lin Liya , Lu Ping , Chen Bin , Zhao Zujin , Qiu Huayu 
Published: November 2012

AbstractExcimers are generally considered as detrimental to OLEDs. For pyrene‐based chromophores, however, this is not always true. In this contribution, two new methylated tetraphenylpyrenes, 1,3,6,8‐tetra‐o‐tolylpyrene (TTPy) and 1,3,6,8‐tetrakis(3,5‐dimethylphenyl)pyrene (TDMPPy), were synthesized through Suzuki coupling reactions. TDMPPy absorbs and emits light at longer wavelengths than TTPy due to its more planar conformation and thus better conjugation. TDMPPy is prone to excimer formation, thus leading to a strong bathochromic shift (84 nm) in the photoluminescence spectrum of its film. TDMPPy exhibits efficient electroluminescence originating from pyrene excimers, affording a maximum luminance of 26 670 cd m−2 and a current efficiency as high as 10.8 cd A−1 in a non‐doped OLED (ITO/PEDOT:PSS (50 nm)/NPB (30 nm)/TDMPPy (30 nm)/TPBI (40 nm)/Ca:Ag).
Problem‐solving test: Nucleocytoplasmic shuttling of pre‐mrna binding proteins
Authors: Szeberényi‡ József 
Published: November 2012

AbstractTerms to be familiar with before you start to solve the test: transcription, pre‐mRNA, RNA processing, RNA transport, RNA polymerase II, direct and indirect immunofluorescence staining, cell fractionation by centrifugation, oligo(dT)‐cellulose chromatography, washing and elution of the column, ribonuclease, SDS‐polyacrylamide gel electrophoresis, Western‐blotting, pre‐ribosomal particles, nuclear envelope, heterokaryon, phase contrast microscopy, polyadenylated RNA.
Aryl Hetaryl Ketones and Thioketones as Efficient Inhibitors of Peptidyl‐Prolyl cis‐trans Isomerases
Authors: Hediger Thomas , Frank Walter , Schumann Michael , Fischer Gunter , Braun Manfred 
Published: November 2012

AbstractA series of 18 differently substituted new aryl hetaryl ketones and thioketones were synthesized in four to six steps from commercial starting materials. The new ketones were evaluated as inhibitors of the peptidyl‐prolyl cis‐trans isomerase hPin1 with Ki values ranging in the one‐digit micromolar to sub‐micromolar numbers. A crystal structure revealed the non‐planar arrangement of the aryl residues at the carbonyl compound and supports the hypothesis that the new compounds might mimic the transition state of the enzymatic conversion.
Physiological Importance of Poly‐(R)‐3‐hydroxybutyrates
Authors: Reusch Rosetta N. 
Published: November 2012

AbstractPoly‐(R)‐3‐hydroxybutyrates (PHB), linear polymers of (R)‐3‐hydroxybutyrate, are components of all biological cells in which short polymers (<200 monomer residues) are covalently attached to certain proteins and/or noncovalently associated with polyphosphates – inorganic polyphosphate (polyP), RNA, and DNA. The low concentrations, lack of unusual atoms or functional groups, and flexible backbones of this complexed PHB, referred to as cPHB, make them invisible to many analytical procedures; whereas other physical properties – water‐insolubility, high intrinsic viscosity, temperature sensitivity, multiple bonding interactions with other molecules – make them requisite participants in vital physiological processes as well as contributors to the development of certain diseases.
On‐Resin Synthesis of an Acylated and Fluorescence‐Labeled Cyclic Integrin Ligand for Modification of Poly(lactic‐co‐glycolic acid)
Authors: Hassert Rayk , Hoffmeister Peter‐Georg , Pagel Mareen , Hacker Michael , Schulz‐Siegmund Michaela , Beck‐Sickinger Annette G. 
Published: November 2012

AbstractCyclic Arg‐Gly‐Asp (RGD) peptides show remarkable affinity and specificity to integrin receptors and mediate important physiological effects in tumor angiogenesis. Additionally, they are one of the keyplayers in improving the biocompatibility of biomaterials. The fully biodegradable polymer poly(lactic‐co‐glycolic acid) (PLGA) is frequently used for biomedical implants and can be applied as nanoparticles for drug delivery. The aim of this work was the generation of a lipidated c[RGDfK] peptide including a second functionality for coating of hydrophobic PLGA. Therefore, we established a general and straightforward strategy for the introduction of two different modifications into the same c[RGDfK] peptide. This allowed the generation of a palmitoylated integrin‐binding lipopeptide that shows high affinity to PLGA. Additionally, we coupled 5(6)‐carboxyfluorescein to the second site for modification to enable sensitive quantification of the immobilized lipopeptide on PLGA. In conclusion, we present a synthesis protocol that enables the preparation of c[RGDfK] lipopeptides with a strong affinity to PLGA and an additional site for modifications. This will provide the opportunity to introduce a variety of effector molecules site‐specifically to the c[RGDfK] lipopeptide, which will enable the introduction of multifunctionality into c[RGDfK]‐coated PLGA devices or nanoparticles.
When Inhibitors Do Not Inhibit: Critical Evaluation of Rational Drug Design Targeting Chorismate Mutase from Mycobacterium tuberculosis
Authors: Munack Steffi , Leroux Vincent , Roderer Kathrin , Ökvist Mats , van Eerde André , Gundersen Lise‐Lotte , Krengel Ute , Kast Peter 
Published: November 2012

AbstractTuberculosis (TB) is a devastating disease that claims millions of lives every year. Hindered access or non‐compliance to medication, especially in developing countries, led to drug resistance, further aggravating the situation. With current standard therapies in use for over 50 years and only few new candidates in clinical trials, there is an urgent call for new TB drugs. A powerful tool for the development of new medication is structure‐guided design, combined with virtual screening or docking studies. Here, we report the results of a drug‐design project, which we based on a publication that claimed the structure‐guided discovery of several promising and highly active inhibitors targeting the secreted chorismate mutase (*MtCM) from Mycobacterium tuberculosis. We set out to further improve on these compounds and synthesized a series of new derivatives. Thorough evaluation of these molecules in enzymatic assays revealed, to our dismay, that neither the claimed lead compounds, nor any of the synthesized derivatives, show any inhibitory effects against *MtCM.
Chemoselective Hydrogenation and Transfer Hydrogenation of Olefins and Carbonyls with the Cluster‐Derived Ruthenium Nanocatalyst in Water
Authors: Indra Arindam , Maity Prasenjit , Bhaduri Sumit , Lahiri Goutam Kumar 
Published: November 2012

AbstractIon pairing of [H3Ru4(CO)12]− with the quaternary ammonium groups of water‐soluble poly(diallyldimethylammonium chloride) gives the precursor of a nanocatalyst for hydrogenation and transfer hydrogenation reactions in water. In hydrogenation reactions, “on water” effect is seen for substrates such as cyclohexanones, methyl pyruvate, acetophenone, and safflower oil. With these substrates, higher turnover numbers are obtained in water than in methanol. The cluster‐derived catalyst shows unique chemoselectivity, which is not seen either in a catalyst prepared through ion pairing of [RuCl4]− with the quaternary ammonium groups of the same polymer or in commercial (5 %) Ru/Al2O3. In contrast to Ru/Al2O3, the [RuCl4]−‐derived catalyst, or many other ruthenium‐based catalytic systems, the cluster‐derived catalyst is totally inert toward the hydrogenation of NO2, CN, and aromatic ring functionalities. In water, typical ketones and aldehydes could be reduced by using the cluster‐derived catalyst and formate as the hydrogen donor. Industrially important cyano‐ and nitrobenzyl alcohols could thus be made from the corresponding aldehydes. High‐resolution TEM data suggest that unique chemoselectivity is a result of highly crystalline ruthenium nanoparticles that consist mainly of Ru(1 1 1) crystal planes.
Potent Inhibitors of Malarial Aspartic Proteases, the Plasmepsins, by Hydroformylation of Substituted 7‐Azanorbornenes
Authors: Aureggi Valentina , Ehmke Veronika , Wieland Joerg , Schweizer W. Bernd , Bernet Bruno , Bur Daniel , Meyer Solange , Rottmann Matthias , Freymond Céline , Brun Reto , Breit Bernhard , Diederich François 
Published: November 2012

AbstractThe increasing prevalence of multidrug‐resistant strains of the malarial parasite Plasmodium falciparum requires the urgent development of new therapeutic agents with novel modes of action. The vacuolar malarial aspartic proteases plasmepsin (PM) I, II, and IV are involved in hemoglobin degradation and play a central role in the growth and maturation of the parasite in the human host. We report the structure‐based design, synthesis, and in vitro evaluation of a new generation of PM inhibitors featuring a highly decorated 7‐azabicyclo[2.2.1]heptane core. While this protonated central core addresses the catalytic Asp dyad, three substituents bind to the flap, the S1/S3, and the S1′ pockets of the enzymes. A hydroformylation reaction is the key synthetic step for the introduction of the new vector reaching into the S1′ pocket. The configuration of the racemic ligands was confirmed by extensive NMR and X‐ray crystallographic analysis. In vitro biological assays revealed high potency of the new inhibitors against the three plasmepsins (IC50 values down to 6 nM) and good selectivity towards the closely related human cathepsins D and E. The occupancy of the S1′ pocket makes an essential contribution to the gain in binding affinity and selectivity, which is particularly large in the case of the PM IV enzyme. Designing non‐peptidic ligands for PM II is a valid route to generate compounds that inhibit the entire family of vacuolar plasmepsins.
ChemInform Abstract: Effects of Scandium Substitution on the Crystal Structure and Luminescence Properties of LuBO3:Ce3+.
Authors: Wu Yuntao , Ren Guohao , Ding Dongzhou , Pan Shangke , Yang Fan 
Published: November 2012

AbstractCrystals of Lu1‐xScxBO3:Ce (x = 0.2, 0.5, 0.7) are prepared by the Czochralski method and characterized by single crystal XRD, Raman spectroscopy, and vacuum UV excitation spectroscopy.
ChemInform Abstract: Optical Properties of the Orchid Colored Silver(II) Fluoride Cs2AgF4.
Authors: Tong Jianwei , Koehler Juergen , Simon Arndt , Lee Changhoon , Whangbo Myung‐Hwan 
Published: November 2012

AbstractThe title compound is synthesized by solid state reaction of stoichiometric amounts of AgF2 and CsF (Pt ampule, 600 K, 24 h) and characterized by UV/VIS diffuse reflectance spectroscopy and DFT calculations.
ChemInform Abstract: Structure, Elasticity, Thermodynamics and High Pressure Behavior of ZnB4O7 and CdB4O7.
Authors: Winkler B. , Castellanos Guzman A. G. , Wiehl L. , Bayarjargal L. , Milman V. 
Published: November 2012

AbstractThe structure of α‐ZnB4O7 is determined by single crystal XRD.
ChemInform Abstract: Ag3PO4/SnO2 Semiconductor Nanocomposites with Enhanced Photocatalytic Activity and Stability.
Authors: Zhang Lili , Zhang Hengchao , Huang Hui , Liu Yang , Kang Zhenhui 
Published: November 2012

AbstractThe title composites are obtained from aqueous solutions of AgOAc, Na2HPO4, and Na2SnO3 at room temperature for 24 h in the dark.
ChemInform Abstract: Base‐Free Conjugate Addition of Aliphatic Nitro Compounds to Enones in BmimNTf2: A Recyclable Synthesis of γ‐Nitro Ketones.
Authors: Mancuso Raffaella , Palmieri Alessandro , Ballini Roberto , Gabriele Bartolo 
Published: November 2012

AbstractThe basic anionic moiety of the ionic liquid allows to occur the reaction in the absence of a base.
ChemInform Abstract: Catalytic Enantioselective Addition of Organoaluminum Reagents to Aldehydes.
Authors: Fernandez‐Mateos Emilio , Macia Beatriz , Yus Miguel 
Published: November 2012

AbstractA chiral binaphthyl derivative is used as an efficient catalyst in the present asymmetric addition of organoaluminum reagents to aromatic and aliphatic aldehydes in the presence of an excess of titanium tetraisopropoxide providing products in mostly high enantioselectivities.
ChemInform Abstract: 3,3′‐Substituted BINAP Derivatives Containing C‐Bound Substituents: Applications in Asymmetric Hydrogenation Reactions.
Authors: Rankic Danica A. , Parvez Masood , Keay Brian A. 
Published: November 2012

AbstractNewly synthesized BINAP derivative is proved to be an efficient ligand in the rhodium‐catalyzed hydrogenation of enamides.
ChemInform Abstract: SO42‐/CexZr1‐xO2 ‐Catalyzed Synthesis of N‐tert‐Butylamides from Various Nitriles under Solvent‐Free Conditions.
Authors: Kahandal Sandeep S. , Kale Sandip R. , Disale Shamrao T. , Jayaram Radha V. 
Published: November 2012

AbstractA modified Ritter reaction using tert‐butyl acetate as carbocation source and Ce(IV)‐doped, sulfated zirconia as catalyst is described.
ChemInform Abstract: Copper(I)‐Catalyzed Asymmetric Desymmetrization: Synthesis of Five‐Membered‐Ring Compounds Containing All‐Carbon Quaternary Stereocenters.
Authors: Aikawa Kohsuke , Okamoto Tatsuya , Mikami Koichi 
Published: November 2012

AbstractThe synthetic value of the present desymmetrization is demonstrated by preparation of some complicated chiral building blocks.
ChemInform Abstract: Solid‐Supported Pd(0): An Efficient Recyclable Heterogeneous Catalyst for Chemoselective Reduction of Nitroarenes.
Authors: Shil Arun K. , Sharma Dharminder , Guha Nitul Ranjan , Das Pralay 
Published: November 2012

AbstractThe formation of aniline derivatives becomes possible under different conditions in the presence of various reducible functional groups.
ChemInform Abstract: Zeise′s Dimer Catalyzed Regioselective Hydration of Homopropargyl Tertiary Ether.
Authors: Zhou Ting , Zhu Guili , Huang Xuan , Liu Bo 
Published: November 2012

AbstractThe method represents an alternative to the aldol reaction or the oxa‐Michael reaction to form prochiral tertiary β‐hydroxy ketone derivatives as important building blocks.
ChemInform Abstract: Synthesis of Novel Chiral Monophosphine Ligands Derived from Isomannide and Isosorbide. Application to Enantioselective Hydrogenation of Olefins.
Authors: Ibrahim Houssein , Bournaud Chloee , Guillot Regis , Toffano Martial , Vo‐Thanh Giang 
Published: November 2012

AbstractLigand (I) and its endo isomer are prepared via different approaches and tested in the title reaction.
ChemInform Abstract: NHC—Pd(II)—Im (NHC=N‐Heterocyclic Carbene, Im=1‐Methylimidazole) Complex Catalyzed Coupling Reaction of Arylboronic Acids with Carboxylic Acid Anhydrides in Water.
Authors: Lin Xiao‐Fang , Li Yao , Li Shuang‐Yan , Xiao Zheng‐Kang , Lu Jian‐Mei 
Published: November 2012

AbstractThe application of a NHC‐metal complex in pure water, which is not developed very popularly to date, is presented for the title reaction.
ChemInform Abstract: 2,6‐Dibenzhydryl‐N‐ (2‐aryliminoacenaphthylenylidene)‐4‐chlorobenzenaminopalladium Dichlorides: Synthesis, Characterization, and Use as Catalysts in the Heck‐Reaction.
Authors: Ban Qing , Zhang Jun , Liang Tongling , Redshaw Carl , Sun Wen‐Hua 
Published: November 2012

AbstractNew title compounds exhibit high thermal stability and good activity in Heck cross‐coupling reactions with conversions greater than 90%.
ChemInform Abstract: CuCl‐Catalyzed Radical Cyclization of N‐α‐Perchloroacyl‐ketene‐N,S‐acetals: A New Way to Prepare Disubstituted Maleic Anhydrides.
Authors: Cornia Andrea , Felluga Fulvia , Frenna Vincenzo , Ghelfi Franco , Parsons Andrew F. , Pattarozzi Mariella , Roncaglia Fabrizio , Spinelli Domenico 
Published: November 2012

AbstractThe presented hexa‐atomic cyclic ketene‐N,S‐acetals show the best results in the title reaction compared with penta‐atomic cyclic ketene‐N,S‐acetals and hexa‐atomic cyclic ketene‐N,N‐acetals.
ChemInform Abstract: Reaction of α‐Nitroacrylates with Acetylacetone.
Authors: Baichurina L. V. , Baichurin R. I. , Aboskalova N. I. , Zobacheva M. M. , Berestovitskaya V. M. 
Published: November 2012

Abstractα‐Nitroacrylates (I) successfully react with acetylacetone in MeOH in the presence of MeONa to give addition products (III), which can undergo an intramolecular O‐alkylation accompanied with elimination of nitrous acid [→ (IV)].
ChemInform Abstract: Generation of 3‐(1H‐Pyrrol‐3‐yl)‐1H‐inden‐1‐ones via a Tandem Reaction of 1‐(2‐Alkynylphenyl)‐2‐enone, 2‐Isocyanoacetate, and Water.
Authors: Zheng Danqing , Li Shaoyu , Wu Jie 
Published: November 2012

AbstractA mechanism for the title reaction is suggested.
ChemInform Abstract: Synthesis of 2‐Substituted Benzimidazoles Catalyzed by FeCl3/Al2O3 under Ultrasonic Irradiation.
Authors: Chen Guo‐Feng , Dong Xiao‐Yun , Meng Fan‐Zhu , Chen Bao‐Hua , Li Ji‐Tai , Wang Shu‐Xiang , Bai Guo‐Yi 
Published: November 2012

AbstractAliphatic aldehydes only give traces of the corresponding product.
ChemInform Abstract: Convenient One‐Step Synthesis of 4‐Unsubstituted 2‐Amino‐4H‐chromene‐2‐carbonitriles and 5‐Unsubstituted 5H‐Chromene[2,3‐b]pyridine‐3‐carbonitriles from Quaternary Ammonium Salts.
Authors: Osyanin Vitaly A. , Osipov Dmitry V. , Klimochkin Yuri N. 
Published: November 2012

AbstractThe reactions are proposed to proceed via o‐quinone methide intermediates.
ChemInform Abstract: Synthesis of Substituted Chiral Chromans via Organocatalytic Kinetic Resolution of Racemic 3‐Nitro‐2‐aryl‐2H‐chromenes with Ketones Catalyzed by Pyrrolidinyl‐Camphor‐Derived Organocatalysts.
Authors: Magar Dhananjay R. , Chen Kwunmin 
Published: November 2012

AbstractThe title method provides a new route for the preparation of functionalized chiral chromans and chromenes.
ChemInform Abstract: A Magnetic Particle Supported Sulfonic Acid Catalyst: Tuning Catalytic Activity Between Homogeneous and Heterogeneous Catalysis.
Authors: Koukabi Nadiya , Kolvari Eskandar , Zolfigol Mohammad Ali , Khazaei Ardeshir , Shaghasemi Behzad Shirmardi , Fasahati Behzad 
Published: November 2012

AbstractSulfonic acid coated γ‐Fe2O3 nanoparticles catalyze the Hantzsch synthesis of dihydropyridines under solvent‐free conditions.
ChemInform Abstract: An Easy Route for the Synthesis of Pyrazine‐2,3‐dicarbonitrile 5,6‐Bis‐substituted Derivatives Using a Palladium Catalyst.
Authors: Ali Hasrat , van Lier Johan E. 
Published: November 2012

AbstractThe use of pyrazines (I) and (IX) in Pd‐catalyzed cross‐coupling reaction is investigated to provide methods for the synthesis of title compounds.
ChemInform Abstract: Dearomatizing Conversion of Pyrazines to 1,4‐Dihydropyrazine Derivatives via Transition‐Metal‐Free Diboration, Silaboration, and Hydroboration.
Authors: Oshima Kazuyuki , Ohmura Toshimichi , Suginome Michinori 
Published: November 2012

AbstractThe efficient dearomatization of pyrazines (I) to 1,4‐dihydropyrazines (III) and (V) and 1,2,3,4‐tetrahydropyrazine (VII) via addition of boron reagents (II), (IV), and (VI) having B—B, Si—B, and H—B bonds is reported.
ChemInform Abstract: para‐Benzihemiporphyrazine and Its Expanded [3 + 3]‐Type Analogue.
Authors: Shimizu Soji , Sato Yuta , Kobayashi Nagao 
Published: November 2012

AbstractThe stepwise and the one‐pot condensation of 1,3‐diiminoisoindoline (I) and para‐phenylenediamine (II) lead to the para‐benzihemiporphyrazine (IV) and its [3 + 3]‐type hemiporphyrazine analogue (V), respectively.
ChemInform Abstract: Ethoxy‐Substituted Oligo‐phenylenevinylene‐Bridged Organic Dyes for Efficient Dye‐Sensitized Solar Cells.
Authors: Shan Yifan , Tang Jie , Lai Hua , Tan Hongwei , Liu Xiaofeng , Yang Fan , Fang Qiang 
Published: November 2012

AbstractCompound (II) exhibits broad IPCE spectra in the range of 350‐750 nm and compound (Ia) shows solar energy‐to‐electricity conversion efficiency up to 4.23%.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Pallambins C and D.
Authors: Xu Xue‐Song , Li Zhen‐Wu , Zhang Yi‐Jun , Peng Xiao‐Shui , Wong Henry N. C. 
Published: November 2012

AbstractThe first total synthesis of the title compounds is accomplished in a linear 38 step sequence starting from racemic Wieland—Mischer ketone.
ChemInform Abstract: Divergent Total Synthesis of the Natural Antimalarial Marinoquinolines A, B, C, E and Unnatural Analogues.
Authors: Schwalm Cristiane Storck , Correia Carlos Roque D. 
Published: November 2012

AbstractThe natural marinoquinolines (VI) and a few non‐natural analogues (VIII) are prepared through Pictet—Spengler reaction of various aldehydes with the key intermediate (IV).
Investigations on Mechanical Stress Caused to CHO Suspension Cells by Standard and Single‐Use Pumps
Authors: Blaschczok Katharina , Kaiser Stephan C. , Löffelholz Christian , Imseng Nicole , Burkart Jürg , Bösch Pascal , Dornfeld Wolfgang , Eibl Regine , Eibl Dieter 
Published: November 2012

AbstractMechanical stress caused to transfected Chinese hamster ovary (CHO) suspension cells by reusable and single‐use magnetically levitated, bearingless centrifugal pumps was investigated. Cell death rates were determined for different pump speeds and compared with data from a peristaltic and a 4‐piston diaphragm pump. Furthermore, the fluid distribution inside the PuraLev® 200 pump was modeled using computational fluid dynamics. The results reveal considerably lower mechanical stress to CHO cells caused by the magnetically levitated bearingless centrifugal pumps than by the peristaltic and diaphragm pump.
An Approach for Scale‐Up of Geometrically Dissimilar Orbitally Shaken Single‐Use Bioreactors
Authors: Werner Sören , Olownia Johanna , Egger Daniel , Eibl Dieter 
Published: November 2012

AbstractAn initial approach for scaling up geometrically dissimilar orbitally shaken bioreactors is presented. A novel ShakerBag Option for Multitron Cell shaking incubators allows a rapid increase in working volume from small TubeSpin bioreactors or shake flasks up to 10 L, thus offering a simple and cost‐efficient alternative to present systems for scale‐up. The engineering parameters for scale‐up of the orbitally shaken single‐use bags were determined using traditional methods. Modern computational fluid dynamics based methods were used to gain a deeper insight into the fluid flow behavior. Furthermore, mass propagation of plant cell suspensions (Nicotiana tabacum and Vitis vinifera), as well as cell expansion and production of protein complexes using insect cells (Sf‐9), show the potential of orbitally shaken single‐use bags.