bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cucumeropsis mannii seed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A
Authors: Ogwoni H. A. , Aja P. M. , Eze Ejike Daniel , Agu P. C. , Moyosore Afodun Adam , Ale B. A. , Ekpono E. U. , Awoke J. N. , Ogbu Patience N. , Ukachi O. U. , Orji O. U. , Nweke P. C. , Egwu C. O. , Ekpono E. U. , Ewa G. O. , Igwenyi I. O. , Alum E. U. , Chukwu D. C. , Aja Lucy , Ani G. O. , Offor C. E. , Yakubu O. E. , Maduagwuna E. , Akobi J. B. , Noreen Sana , Awuchi Chinaza Godswill 
Published: August 2024

AbstractBisphenol A, a traditional endocrine disruptor, has been implicated in male infertility. This study investigated the effect of Cucumeropsis mannii seed oil (CMSO) on bisphenol A (BPA)‐induced biochemical toxicity in the testicular mitochondria of male albino rats. The rats were assigned randomly to six experimental groups (n = 6), A, B, C, D, E, and F. Group A received 1 mL of olive oil. Groups B and C received 100 mL/kg body weight (BW) of BPA and 7.5 mL/kg BW CMSO, respectively. Rats in groups D, E, and F received preadministered doses of 100 mL/kg BW of BPA, 5 mL/kg BW of BPA, and 2.5 mL/kg BW of CMSO, respectively, followed by 6 weeks of exposure to those doses. Some mitochondrial enzymes, mitochondrial membrane potential (MMP), mitochondria testicular protein, and body weight of rats were determined using standard methods. BPA significantly reduced succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase, NADH dehydrogenase, and monoamine oxidase activity. Also, BPA prominently decreased the MMP, mitochondrial testicular protein, and body weight of rats. Interestingly, coadministration of BPA and CMSO restored the dysregulated activities of the enzymes and levels of other biomarkers. We postulated that CMSO may be a promising drug for treating systemic toxicity caused by environmental toxicants such as BPA.
In vitro and in vivo investigation of the biological action of xylooligosaccharides derived from industrial waste
Authors: Chinbat Odgerel , Erdenetsog Purevdulam , Tuvshintur Buyankhuu , Gantumur Anuujin , Burenjargal Munkhjargal , Chimeddorj Battogtokh , Janlav Munkhtsetseg 
Published: August 2024

AbstractXylooligosaccharides (XOS) are prebiotics of significant biological value that can be obtained through cost‐effective purification of agricultural waste. The present research featured in vitro and in vivo investigation of prebiotic effects of xylooligosaccharides derived from wheat bran powder and brewer's spent grain. Prebiotic activity of Lactobacillus. fermentum, Lactobacillus. casei, and Bifidobacterium spp. was investigated in vitro using standard selective media. 16S rRNA quantitative PCR used for in vitro and in vivo investigation quantified relative abundance of Bifidobacterium spp., Lactobacillus spp., and Akkermansia. muciniphila in samples of fecal matter, cecal content, and intestinal tissue. Research revealed a favorable association between XOS concentration and both bacterial count and diameter of resultant colonies. The standard strain of L. casei showed no noticeable effect on growth rate. Bifidobacterium spp. proliferation in intestinal tissue was validated via in vivo tests using XOS obtained from wheat bran powder and brewer's spent grain. Findings indicated increased prevalence of the A. muciniphila species and the presence of XOS showed a protective function in preserving the structural integrity of intestinal mucus secretions. The presence of XOS in food indicated direct association with proliferation of Bifidobacterium spp. and A. muciniphila spp. Study results suggest that XOS extracted through enzymatic hydrolysis in Mongolian food industry by‐products such as wheat bran products and brewer's spent grain exhibit prebiotic properties that justify XOS manufacture on a large scale and incorporation of XOS as nutritional enhancement in food products and pharmaceuticals.
A preliminary study on the use of phycocyanin as a natural blue color source in toffee‐type soft candy: Effect of storage temperature and pigment concentration
Authors: Gunes Recep , Palabiyik Ibrahim , Kurultay Sefik 
Published: August 2024

AbstractIn this study, phycocyanin obtained from Spirulina platensis extract was used at various concentrations as a natural blue color source in toffee‐type soft candy, and the effect of various storage temperatures (4, 20, and 40°C) on the color stability was investigated. In addition, main quality parameters, such as water activity, texture, and sensory analysis, were determined in the samples stored for 3 months at 20°C, and thus the effect of phycocyanin addition on the product appeal was studied. According to the results, the addition of phycocyanin powder did not significantly affect water activity (p > .05). As expected, L*, a*, and b* values of the samples changed with the phycocyanin, and the ΔE values of the samples stored at 4, 20, and 40°C varied between 0.14–0.44, 0.84–2.76, and 2.63–7.90, respectively, during the entire storage period. The texture analysis outputs revealed that the use of phycocyanin did not cause any change in the textural properties of the samples (p > .05). Considering the sensory analysis, all studied concentrations scored high in terms of color liking, and the use of phycocyanin in toffee‐type soft candy production resulted in a remarkable consumer appeal. Hence, the outcomes of this study show that if temperature control is performed in the production, the organoleptic properties of toffee‐type candy products can be enhanced using phycocyanin and can meet consumer requests and demands.
Money and mental health: The impact of intergenerational transfers on elderly people in China
Authors: Appleton Simon , Huang Jinying , Lou Xuyan , Zhou Minghai 
Published: August 2024

AbstractUsing three waves of the China Health and Retirement Longitudinal Study, this paper examines whether financial transfers from adult children to elderly parents affect the latter's mental health. Both OLS and instrumental variable (IV) estimates show that financial transfers significantly attenuate depressive symptoms of elderly individuals, with a much larger size of the IV estimates. We also examine the income and cultural channels through which intergenerational transfers work and further discuss the explanatory powers of these two channels through a decomposition analysis. The results suggest the cultural channel accounts for a larger proportion of the financial transfer effect. This means that the unique beneficial impact of intergenerational financial transfers on the mental health of older adults cannot be fully substituted in the foreseeable future.
Characteristics, outcomes and health care utilization of patients with acute myeloid leukemia aged 70 years or older: A single‐center retrospective analysis
Authors: Neumann Marie Anne‐Catherine , Naendrup Jan‐Hendrik , Garcia Borrega Jorge , Halmer Ismini , Altenrath Lisa , Sieg Noelle , Hallek Michael , Eichenauer Dennis A. , Heger Jan‐Michel 
Published: August 2024

AbstractThe overall prognosis of older patients with acute myeloid leukemia (AML) is dismal. Only a small subgroup experiences long‐term survival. The discrimination between patients who are candidates for potentially curative approaches and those who are not is crucial since ‐ in addition to differences in terms of AML‐directed treatment ‐ different policies concerning intensive care unit (ICU) admission and involvement of specialized palliative care (SPC) seem obvious. To shed more light on characteristics, outcomes and health care utilization of older individuals with AML, we conducted an analysis comprising 107 consecutive patients with newly diagnosed AML aged ≥70 years treated at an academic tertiary care center in Germany between 1 January 2015, and 31 December 2020. Median age was 75 years (range: 70–87 years); 45% of patients were female. The proportion of patients receiving intensive induction chemotherapy was 35%, 55% had low‐intensity treatment and 10% did not receive AML‐directed treatment or follow‐up ended before treatment initiation. At least one ICU admission was documented for 47% of patients; SPC was involved in 43% of cases. Median follow‐up was 199 days. The median overall survival (OS) was 2.5 months; the 1‐year OS rate was 16%. Among patients who died during observation, the median proportion of time spent in the hospital between AML diagnosis and death was 56%. The most common places of death were normal wards (31%) and the ICU (28%). Patients less frequently died in a palliative care unit (14%) or at home (12%). In summary, results of the present analysis confirm the unfavorable prognosis of older patients with AML despite intensive health care utilization. Future efforts in this patient group should aim at optimizing the balance between appropriate AML‐directed treatment on the one hand and health care utilization including ICU stays on the other hand.
Rectal perforation following SpaceOAR placement combined with permanent prostate brachytherapy
Authors: Morita Masashi , Tanabe Mayo , Kinugawa Chisa , Nakamura Saori , Amano Satoshi , Nishimura Kota , Yamatoya Jin , Noguchi Tetsuo , Hiramatsu Aya , Fukagai Takashi 
Published: August 2024

IntroductionWe report a case of rectal perforation following SpaceOAR placement utilized with iodine‐125 low‐dose‐rate brachytherapy for prostate cancer.Case presentationA 65‐year‐old patient with localized prostate cancer underwent SpaceOAR placement following LDR‐BT. No significant issues occurred with the SpaceOAR procedure, and no abnormalities were found on the next day's T2‐weighted magnetic resonance imaging. Two weeks later, a colonoscopy was performed due to mucus stools revealing rectal perforation attributed to SpaceOAR. By maintaining Macrogol 4000 and a low residue diet, the perforation healed within 6 months.ConclusionRectal ulcers and perforations are the most common severe adverse events from SpaceOAR placement. Effective management strategies are crucial since complications can't be entirely avoided, even with skilled surgeons.
Promoting uniform lithium deposition with Janus gel polymer electrolytes enabling stable lithium metal batteries
Authors: Wang Lin , Xu Shugang , Song Zihui , Jiang Wanyuan , Zhang Shouhai , Jian Xigao , Hu Fangyuan 
Published: August 2024

AbstractLithium metal batteries (LMBs) are desirable candidates owing to their high‐energy advantage for next‐generation batteries. However, the practical application of LMBs continues to be constrained by thorny safety issues with the formation and growth of Li dendrites. Herein, the ZIF‐67 MOFs are in situ coupled onto a single face of 3D porous nanofiber to fabricate an asymmetric Janus membrane, harnessing their anion adsorption capabilities to promote the uniform deposition of Li ions. In addition, the poly(ethylene glycol) diacrylate and trifluoromethyl methacrylate are introduced into nanofiber skeleton to form Janus@GPE, which preferentially reacts with Li metal to form a LiF‐rich stable SEI layer to inhibit Li dendrite growth. Importantly, the synergistic effect of the MOFs and stable solid electrolyte interphase (SEI) layer results in superior cycling performance, achieving a remarkable 2500 h cycling at 1 mA cm−2 in the Li/Janus@GPE/Li configuration. In addition, the Janus@GPE electrolyte has a certain flame retardant, which can self‐extinguish within 3 s, improving the safety performance of the batteries. Consequently, the Li/Janus@GPE/LFP flexible pouch cell exhibits favorable cycling stability (the capacity retention rate of 45 cycles is 91.8% at 0.1 C). This work provides new insights and strategies to improve the safety and practical utility of LMBs.image
Rational composition engineering for high‐quality Pb–Sn photodetector toward sensitive near‐infrared digital imaging arrays
Authors: Li Huan , Gao Yu , Hong Xin , Ke Kanghui , Ye Zilong , Zhang Siwei , Shi Kefei , Peng Zhuo , Yan Hao , Tang Man‐Chung , Yao Youwei , Tang Ben Zhong , Wei Guodan , Kang Feiyu 
Published: August 2024

AbstractBroadband photodetectors (PDs) capable of multi‐wavelength detection have garnered significant interest for applications in environmental monitoring, optical communication, spectral analysis, and imaging sensing. Low‐bandgap Pb–Sn hybrid perovskite photodetectors can extend the spectral response from the ultraviolet–visible (UV–vis) range to the near‐infrared (NIR) and reduce the toxicity associated with Pb2+. The strategic introduction of Sn2+ into Cs0.15FA0.85PbxSn1−xI3 (x = 1, 0.8, 0.6, 0.5, 0.4, 0.2, and 0) not only preserves the cubic crystal structure with conformal multigrain growth but also broadens the film's absorption spectrum from 800 to 1000 nm NIR region. This indicates a well‐controlled tunability of the Pb–Sn binary perovskite system. Specifically, the self‐powered photodetector with a device structure of ITO/NiOx/PTAA/Cs0.15FA0.85Pb0.5Sn0.5I3/PCBM/BCP/Ag has shown remarkable optoelectrical properties. It exhibits a high external quantum efficiency (EQE) of up to 80% across the spectrum from 300 to 1000 nm, a responsivity (R) exceeding 0.5 A/W, and high detectivity (D*) value of 1.04 × 1012 Jones at 910 nm and 3.38 × 1011 Jones at 1000 nm after weak attenuation. Intriguingly, the dark current of the Cs0.15FA0.85Pb0.5Sn0.5I3 device is four orders of magnitude lower than that of devices made with pristine Pb or Sn only, strongly correlating with its significantly increased built‐in potential and reduced trap density. Consequently, it demonstrates a −3 dB bandwidth of 2.23 × 104 Hz, fast rise and decay times of 61 and 30 μs, respectively, and a linear dynamic range (LDR) of 155 dB. Benefiting from its high sensitivity, a 5 × 5 PD array for NIR imaging and non‐invasive pulse detection for photoplethysmography applications has been successfully demonstrated, showcasing the prosperous potential of Pb–Sn hybrid perovskite in the NIR range.image
Writing globally: South Korean adolescents' digital multimodal composing practices in a global online community
Authors: Jung Jin Kyeong 
Published: August 2024

AbstractThis design‐based study explored the digital and linguistic practices of South Korean adolescents from a rural area within the Write4Change global online community, emphasizing their use of image‐driven tools. Framed within the cosmopolitan literacies perspective, these adolescents adeptly merge local and global dimensions, integrating their multilingual identities, and compelling visual narratives into their work. They navigate English, the dominant language of the online community, while incorporating multilingual elements to enrich community dialogues. These practices reflect their linguistic adaptability and digital literacies and underscore the significant role of cosmopolitan literacies in transforming literacy studies. The study highlights the impactful digital practices of South Korean adolescents, contributing to a broader understanding of inclusivity and diversity in global literacies.
Intolerance of uncertainty dimensions and alcohol problems: The effects of coping motives and heavy drinking
Authors: Wahesh Edward , Ondrejack Lauren 
Published: August 2024

AbstractThis study explored the roles of coping motives and frequency of heavy drinking episodes on the association between intolerance of uncertainty (IU) dimensions (i.e., prospective IU and inhibitory IU) and alcohol problems in a crowdsourced sample of 375 adult drinkers. Serial mediation results indicated that there was a significant positive indirect effect of inhibitory IU on alcohol problems via coping motives and heavy drinking episodes. Unexpectedly, prospective IU had significant negative effects on frequency of heavy drinking episodes and alcohol problems. Implications of the study findings are discussed.
Simulating the full spin manifold of triplet‐pair states in a series of covalently linked TIPS‐pentacenes
Authors: Schulz Timo , Marian Christel M. 
Published: August 2024

AbstractCombined density functional theory and multireference configuration interaction methods have been used to elucidate singlet fission (SF) pathways and mechanisms in three regioisomers of side‐on linked pentacene dimers. In addition to the optically bright singlets (S and S) and singly excited triplets (T and T), the full spin manifold of multiexcitonic triplet‐pair states (ME, ME, ME) has been considered. In the ortho‐ and para‐regioisomers, the ME and S potentials intersect upon geometry relaxation of the S excitation. In the meta‐regioisomer, the crossing occurs upon delocalization of the optically bright excitation. The energetic accessibility of these conical intersections and the absence of low‐lying charge‐transfer states suggests a direct SF mechanism, assisted by charge‐resonance effects in the ME state. While the ME state does not appear to play a role in the SF mechanism of the ortho‐ and para‐regioisomers, its participation in the disentanglement of the triplet pair is conceivable in the meta‐regioisomer.
Selective detection of ketamine in human urine samples by electrochemiluminescence sensor based on conductive molecular imprinted polypyrrole: A hydrogen peroxide‐free electrochemiluminescence assay
Authors: Ahmadi Farzane , Alizadeh Naader 
Published: August 2024

AbstractA new sensor was fabricated for the determination of ketamine (Ket) in urine samples based on enhanced electrochemiluminescence (EECL) behavior of luminol on a carbon paste electrode (CPE) modified with the conductive molecularly imprinted polymer (CMIP) film. The FESEM technique was applied to demonstrate the rod shape morphology of CMIP. Unlike the common luminol system, EECL signal of luminol no need to addition of hydrogen peroxide and it might find application in efforts to avoid instability of hydrogen peroxide or its interference with the analytes of interest. The EECL emission has been optimized by an investigation of the applied potentials, electrochemical polymerization conditions, template and modifier concentrations, and the pH solution. Under the optimum conditions, the EECL signal depended linearly on the Ket concentration within a range from 0.1 to 1.25 μM with a limit of detection (LOD) of 0.08 μM. The sensor exhibited very good recovery percentages ranging from 92% to 101% in urine samples, while precisions were ≤3%. These results suggested that the proposed sensor would be applicable for analysis Ket in complex matrixes without interfering of other drugs (anesthetics) and thus has the potential to be used in clinical application.
Amperometric sensor based on carbon nanotube, ionic liquid, and polyaspartic acid for ascorbic acid determination
Authors: Mnati Fatimah Alzahraa Nabeel , Okman Koçoğlu İrem 
Published: August 2024

AbstractAn amperometric sensor for ascorbic acid determination has been developed by modifying the surface of a glassy carbon electrode (GCE) with polyaspartic acid (PolyAsp), carboxylated multi‐walled carbon nanotube (c‐MWCNT), and ionic liquid (IL, 1‐butyl‐3‐methylimidazolium hexafluorophosphate). The amount of each modification material on the surface was optimized in order to achieve good analytical performance. The operating conditions of c‐MWCNT−IL/PolyAsp/GCE were optimized. The performance characteristics of c‐MWCNT−IL/PolyAsp/GCE were investigated at optimum pH (8.0) and optimum potential (+0.20 V), and the sensor responded linearly to ascorbic acid between 5.3–2766.3 μM with a sensitivity of 19.64 μA mM−1 and detection limit of 3.0 μM. Determination of ascorbic acid in vitamin C tablet, vitamin C injection solution, and orange juice was successfully performed with the presented sensor and the recovery values were found between 98.9% and 101.6%.
First birth after uterine transposition in low‐volume lymph node metastasis of cervical cancer: A long journey for success
Authors: Moretti‐Marques Renato , Franca Ive Bahia , de Cillo Pedro Ernesto , Alvarenga‐Bezerra Vanessa , Helito Juliana Karassawa , Filho Donato Callegaro , Kim Nam Jin , Ribeiro Reitan 
Published: August 2024

AbstractLocally advanced cervical cancer poses a significant challenge to fertility‐sparing treatments. Pelvic radiotherapy impairs reproductive potential owing to ovarian, uterine, and endometrial side effects. This study presents a literature review of the main fertility‐sparing therapeutic alternatives for locally advanced cervical cancer and a case report of the first childbirth following uterine transposition for gynecological malignancies.
A case of primary cutaneous CD8+ aggressive epidermotropic cytotoxic T‐cell lymphoma
Authors: Shimizu Tomomichi , Takahashi Nobuhiro , Okaniwa Aya , Saito Reiko , Kondoh Akio , Yamazaki Fumikazu , Nagase Shunsuke , Nakamura Naoya , Takeuchi Kazuya , Mabuchi Tomotaka 
Published: August 2024

AbstractA 65‐year‐old Japanese woman with primary cutaneous CD8+ aggressive epidermotropic cytotoxic T‐cell lymphoma, a rare type with a poor prognosis, is presented. Oral bexarotene and vorinostat were ineffective, and hematopoietic stem cell transplantation was scheduled. We stress that primary cutaneous CD8+ aggressive epidermotropic cytotoxic T‐cell lymphoma should be treated with bone marrow transplantation when available.
Presoaking hamstring autograft with vancomycin does not jeopardize its biomechanical properties, including graft elongation, after cyclic loading
Authors: Park Hyung Jun , Yoon Chan , Kang Seung‐Baik , Kim Tae Woo , Chang Chong Bum , Bae Tae Soo , Chang Moon Jong , Kwak Dai‐Soon 
Published: August 2024

AbstractPurposePresoaking the graft with vancomycin before implantation has been shown to reduce the risk of postoperative infection after anterior cruciate ligament reconstruction (ACLR). However, the effects of presoaking on the graft biomechanical properties remain unclear. This study aimed to determine whether presoaking the graft with vancomycin affects the graft biomechanical properties and length after cyclic loading.MethodsTen paired (20 specimens) gracilis and semitendinous tendons were harvested from fresh‐frozen human cadaveric specimens. Two tendons were folded in half to make four strands, and the grafts were randomized into the vancomycin and control groups. The graft was exposed to the antibiotic solution for 15 min (5 mg/mL) and prepared by mixing 1 g of vancomycin with 200 mL of normal saline (NaCl 0.9%). The control group was soaked in normal saline for 15 min. The prepared grafts were attached to the actuator of a dynamic tensile‐testing machine. All grafts were tested with 3000 cycles of cyclic loading followed by a pull‐to‐failure. The cyclic loading protocol consisted of position and load control blocks to simulate the graft in vivo in the postoperative phase after ACLR.ResultsPresoaking in vancomycin did not jeopardize the biomechanical properties of the graft. In addition, presoaking with vancomycin did not elongate the grafts. No significant differences were found in the mean Young's modulus and the mean total elongation of the graft of the specimen between the vancomycin group and the control group.ConclusionPresoaking the graft with vancomycin jeopardized neither its biomechanical properties nor elongation even after cyclic loading in this in vitro study. It is suggested that vancomycin presoaking could be considered a safe and effective preventive measure for postoperative infections after ACLR.Level of EvidenceNot applicable.