bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’agency de Juliette Adam (1836-1936)
Authors: D’Agostini Aldo 
Published: February 2013

Grâce à ses rôles d’hôtesse de salon et de directrice de revue, et avec ses combats épiques pour la République et pour la Patrie, Juliette Adam a joué un rôle important dans la vie politique française de la seconde moitié du XIXe siècle. Elle a notamment contribué à la fabrication d’une nouvelle classe dirigeante et conditionné l’adoption de certains choix de politique étrangère. Dans cet article, nous reconstruisons le parcours de cette « femme politique » en focalisant notre attention sur sa capacité d’agir au sein de la vie politique française. Notre objectif est d’illustrer le processus à travers lequel cette capacité d’agir (agency) a été rendue possible et a pu se perpétuer dans le temps.
Inspecteurs des salaisons et marchands de salines : commerce et contrôle du « poisson de conserve » à Marseille au XVIIIe siècle
Authors: Faget Daniel 
Published: February 2013

D’origine locale ou atlantique, le poisson constitue à l’époque moderne l’un des produits essentiels du commerce méditerranéen. Organisée de manière complexe, sa distribution alimente les marchés portuaires. Denrée périssable, la vente du poisson suscite toutefois la méfiance des autorités, qui édictent des normes d’hygiène au début du XVIIIe siècle. Les procès-verbaux dressés par les inspecteurs des « salines » à l’issue de leurs visites dans les cales des navires et les entrepôts du port permettent de mieux cerner pratiques délictueuses et organisation de la distribution. Le sort réservé aux marchandises saisies, systématiquement immergées dans des eaux peu profondes, révèle enfin une représentation du milieu marin comme paré de vertus prophylactiques.
The α7β0 Isoform of the Complement Regulator C4b-Binding Protein Induces a Semimature, Anti-Inflammatory State in Dendritic Cells
Authors: Olivar Rut , Luque Ana , Naranjo-Gómez Mar , Quer Josep , García de Frutos Pablo , Borràs Francesc E. , Rodríguez de Córdoba Santiago , Blom Anna M. , Aran Josep M. 
Published: February 2013

Abstract
The classical pathway complement regulator C4b-binding protein (C4BP) is composed of two polypeptides (α- and β-chains), which form three plasma oligomers with different subunit compositions (α7β1, α7β0, and α6β1). We show in this article that the C4BP α7β0 isoform (hereafter called C4BP[β−] [C4BP lacking the β-chain]), overexpressed under acute-phase conditions, induces a semimature, tolerogenic state on human monocyte-derived dendritic cells (DCs) activated by a proinflammatory stimulus. C4BP isoforms containing β-chain (α7β1 and α6β1; C4BP[β+]) neither interfered with the normal maturation of DCs nor competed with C4BP(β−) activity on these cells. Immature DCs (iDCs) treated with C4BP(β−) retained high endocytic activity, but, upon LPS treatment, they did not upregulate surface expression of CD83, CD80, and CD86. Transcriptional profiling of these semimature DCs revealed that treatment with C4BP(β−) prevented the induction of IDO and BIC-1, whereas TGF-β1 expression was maintained to the level of iDCs. C4BP(β−)–treated DCs were also unable to release proinflammatory Th1 cytokines (IL-12, TNF-α, IFN-γ, IL-6, IL-8) and, conversely, increased IL-10 secretion. They prevented surface CCR7 overexpression and, accordingly, displayed reduced chemotaxis, being morphologically indistinguishable from iDCs. Moreover, C4BP(β−)-treated DCs failed to enhance allogeneic T cell proliferation, impairing IFN-γ production in these cells and, conversely, promoting CD4+CD127low/negCD25highFoxp3+ T cells. Deletion mutant analysis revealed that the complement control protein-6 domain of the α-chain is necessary for the tolerogenic activity of C4BP(β−). Our data demonstrate a novel anti-inflammatory and immunomodulatory function of the complement regulator C4BP, suggesting a relevant role of the acute-phase C4BP(β−) isoform in a number of pathophysiological conditions and potential applications in autoimmunity and transplantation.
HLA Reduces Killer Cell Ig-like Receptor Expression Level and Frequency in a Humanized Mouse Model
Authors: van Bergen Jeroen , Thompson Allan , van Pel Melissa , Retière Christelle , Salvatori Daniela , Raulet David H. , Trowsdale John , Koning Frits 
Published: February 2013

Abstract
NK cells use NK cell receptors to be able to recognize and eliminate infected, transformed, and allogeneic cells. Human NK cells are prevented from killing autologous healthy cells by virtue of inhibitory NKRs, primarily killer cell Ig-like receptors (KIR) that bind “self” HLA class I molecules. Individual NK cells stably express a selected set of KIR, but it is currently disputed whether the fraction of NK cells expressing a particular inhibitory KIR is influenced by the presence of the corresponding HLA ligand. The extreme polymorphism of the KIR and HLA loci, with wide-ranging affinities for individual KIR and HLA allele combinations, has made this issue particularly hard to tackle. In this study, we used a transgenic mouse model to investigate the effect of HLA on KIR repertoire and function in the absence of genetic variation inside and outside the KIR locus. These H-2Kb−/− and H-2Db−/− mice lacked ligands for inhibitory Ly49 receptors and were transgenic for HLA-Cw3 and a KIR B haplotype. In this reductionist system, the presence of HLA-Cw3 reduced the frequency of KIR2DL2+ cells, as well as the surface expression levels of KIR2DL2. In addition, in the presence of HLA-Cw3, the frequency of NKG2A+ cells and the surface expression levels of NKG2A were reduced. In line with these findings, both transgene-encoded KIR and endogenous NKG2A contributed to the rejection of cells lacking HLA-Cw3. These findings support the idea that HLA influences the human KIR repertoire.
Priming of CD8+ T Cells against Cytomegalovirus-Encoded Antigens Is Dominated by Cross-Presentation
Authors: Busche Andreas , Jirmo Adan Chari , Welten Suzanne P. M. , Zischke Jasmin , Noack Julia , Constabel Hannelore , Gatzke Anna-Katherina , Keyser Kirsten A. , Arens Ramon , Behrens Georg M. N. , Messerle Martin 
Published: February 2013

Abstract
CMV can infect dendritic cells (DCs), and direct Ag presentation could, therefore, lead to the priming of CMV-specific CD8+ T cells. However, CMV-encoded immune evasins severely impair Ag presentation in the MHC class I pathway; thus, it is widely assumed that cross-presentation drives the priming of antiviral T cells. We assessed the contribution of direct versus cross priming in mouse CMV (MCMV) infection using recombinant viruses. DCs infected with an MCMV strain encoding the gB498 epitope from HSV-1 were unable to stimulate in vitro naive gB498-specific CD8+ T cells from TCR transgenic mice. Infection of C57BL/6 mice with this recombinant virus led, however, to the generation of abundant numbers of gB498-specific T cells in vivo. Of the DC subsets isolated from infected mice, only CD8α+ DCs were able to stimulate naive T cells, suggesting that this DC subset cross-presents MCMV-encoded Ag in vivo. Upon infection of mice with MCMV mutants encoding Ag that can either be well or hardly cross-presented, mainly CD8+ T cells specific for cross-presented epitopes were generated. Moreover, even in the absence of immune evasion genes interfering with MHC class I–mediated Ag presentation, priming of T cells to Ag that can only be presented directly was not observed. We conclude that the host uses mainly DCs capable of cross-presentation to induce the CMV-specific CD8+ T cell response during primary, acute infection and discuss the implications for the development of a CMV vaccine.
A Polyglutamic Acid Motif Confers IL-27 Hydroxyapatite and Bone-Binding Properties
Authors: Tormo Aurélie Jeanne , Beaupré Linda Ann , Elson Greg , Crabé Sandrine , Gauchat Jean-François 
Published: February 2013

Abstract
The p28 subunit of the composite cytokine IL-27 comprises a polyglutamic acid domain, which is unique among type I cytokines. This domain is very similar to the acidic domain known to confer hydroxyapatite (HA)-binding properties and bone tropism to bone sialoprotein. We observed IL-27 binding to HA, in accordance with previous studies reporting successful p28 HA chromatography. The IL-27 polyglutamic acid domain is located in a flexible inter-α helix loop, and HA-bound IL-27 retained biological activity. Using IL-27 alanine mutants, we observed that the p28 polyglutamic acid domain confers HA- and bone-binding properties to IL-27 in vitro and bone tropism in vivo. Because IL-27 is a potent regulator of cells residing in endosteal bone marrow niches such as osteoclasts, T regulatory, memory T, plasma, and stem cells, this specific property could be beneficial for therapeutic applications. IL-27 has potent antitumoral and antiosteoclastogenic activities. It could therefore also be useful for therapies targeting hematologic cancer or solid tumors metastasis with bone tropism. Furthermore, these observations suggest that polyglutamic motifs could be grafted onto other type I cytokine inter-α helix loops to modify their pharmacological properties.
Control of Tumor-Associated Macrophage Alternative Activation by Macrophage Migration Inhibitory Factor
Authors: Yaddanapudi Kavitha , Putty Kalyani , Rendon Beatriz E. , Lamont Gwyneth J. , Faughn Jonathan D. , Satoskar Abhay , Lasnik Amanda , Eaton John W. , Mitchell Robert A. 
Published: February 2013

Abstract
Tumor stromal alternatively activated macrophages are important determinants of antitumor T lymphocyte responses, intratumoral neovascularization, and metastatic dissemination. Our recent efforts to investigate the mechanism of macrophage migration inhibitory factor (MIF) in antagonizing antimelanoma immune responses reveal that macrophage-derived MIF participates in macrophage alternative activation in melanoma-bearing mice. Both peripheral and tumor-associated macrophages (TAMs) isolated from melanoma bearing MIF-deficient mice display elevated proinflammatory cytokine expression and reduced anti-inflammatory, immunosuppressive, and proangiogenic gene products compared with macrophages from tumor-bearing MIF wild-type mice. Moreover, TAMs and myeloid-derived suppressor cells from MIF-deficient mice exhibit reduced T lymphocyte immunosuppressive activities compared with those from their wild-type littermates. Corresponding with reduced tumor immunosuppression and neo-angiogenic potential by TAMs, MIF deficiency confers protection against transplantable s.c. melanoma outgrowth and melanoma lung metastatic colonization. Finally, we report for the first time, to our knowledge, that our previously discovered MIF small molecule antagonist, 4-iodo-6-phenylpyrimidine, recapitulates MIF deficiency in vitro and in vivo, and attenuates tumor-polarized macrophage alternative activation, immunosuppression, neoangiogenesis, and melanoma tumor outgrowth. These studies describe an important functional contribution by MIF to TAM alternative activation and provide justification for immunotherapeutic targeting of MIF in melanoma patients.
Comparative Analysis of the Magnitude, Quality, Phenotype, and Protective Capacity of Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells following Human-, Simian-, and Chimpanzee-Derived Recombinant Adenoviral Vector Immunization
Authors: Quinn Kylie M. , Da Costa Andreia , Yamamoto Ayako , Berry Dana , Lindsay Ross W. B. , Darrah Patricia A. , Wang Lingshu , Cheng Cheng , Kong Wing-Pui , Gall Jason G. D. , Nicosia Alfredo , Folgori Antonella , Colloca Stefano , Cortese Riccardo , Gostick Emma , Price David A. , Gomez Carmen E. , Esteban Mariano , Wyatt Linda S. , Moss Bernard , Morgan Cecilia , Roederer Mario , Bailer Robert T. , Nabel Gary J. , Koup Richard A. , Seder Robert A. 
Published: February 2013

Abstract
Recombinant adenoviral vectors (rAds) are the most potent recombinant vaccines for eliciting CD8+ T cell–mediated immunity in humans; however, prior exposure from natural adenoviral infection can decrease such responses. In this study we show low seroreactivity in humans against simian- (sAd11, sAd16) or chimpanzee-derived (chAd3, chAd63) compared with human-derived (rAd5, rAd28, rAd35) vectors across multiple geographic regions. We then compared the magnitude, quality, phenotype, and protective capacity of CD8+ T cell responses in mice vaccinated with rAds encoding SIV Gag. Using a dose range (1 × 107–109 particle units), we defined a hierarchy among rAd vectors based on the magnitude and protective capacity of CD8+ T cell responses, from most to least, as: rAd5 and chAd3, rAd28 and sAd11, chAd63, sAd16, and rAd35. Selection of rAd vector or dose could modulate the proportion and/or frequency of IFN-γ+TNF-α+IL-2+ and KLRG1+CD127−CD8+ T cells, but strikingly ∼30–80% of memory CD8+ T cells coexpressed CD127 and KLRG1. To further optimize CD8+ T cell responses, we assessed rAds as part of prime-boost regimens. Mice primed with rAds and boosted with NYVAC generated Gag-specific responses that approached ∼60% of total CD8+ T cells at peak. Alternatively, priming with DNA or rAd28 and boosting with rAd5 or chAd3 induced robust and equivalent CD8+ T cell responses compared with prime or boost alone. Collectively, these data provide the immunologic basis for using specific rAd vectors alone or as part of prime-boost regimens to induce CD8+ T cells for rapid effector function or robust long-term memory, respectively.
Rear Cover: Courtly Love in the Caucasus: Rustaveli’s Georgian Epic, The Knight in the Panther Skin
Authors: Ecklund Farrell Dianne 
Published: February 2013

The Knight in the Panther Skin by Shota Rustaveli is the great medieval (ca. 1200) epic of Georgia, and its most distinctive feature is courtly or romantic love, which is its basic motivating force. This article seeks to establish in which respects The Knight in the Panther Skin resembles Western courtly love, and what the explanation for this resemblance might be. In this endeavor I have had to challenge a common (mis-) conception that Western courtly love was essentially illicit loveOne can easily demonstrate that the literary roots of The Knight in the Panther Skin lie in Persian literature rather than in direct contact with Western courtly love, but the reason for the resemblance to Western courtly love is more problematic. Various possibilities are entertained: namely, (1) that Arab love poetry gave rise to it in Georgia (and possibly also in the West, as has been held); (2) that Neoplatonism produced or constituted a philosophic underpinning for courtly love and that it was transmitted to Georgia and/or Western Europe (a) by Arab Neoplatonists; (b) by Western Christian Neoplatonists or (c) by Byzantine Neoplatonists. A third possibility is (3) that it arose due to social and political conditions. And what were the social and political circumstances in Georgia and in Western Europe which, at the same historical period, produced and elaborated a culture so deferential to the ladies? And which, being absent in the Islamic world, did not produce courtly love there? In Georgia a sovereign queen presided in the era of Georgia’s greatest power, wealth and extent. Feudal servitors crowded the court, eager to gain honors and riches for themselves through preferment by the queen, virtually guaranteeing a cult of adoration of the queen. It is Sovereign Queen Tamar to whom Rustaveli dedicates his poem, and to her that he declares his undying love. In Provence, where there were many feudal heiresses, a similar incentive to “please the ladies” prevailed. No direct influence from the troubadours and minnesaenger of Southwestern Europe can be found. The evidence does not support Arab love poetry as a source of or conduit for courtly love, nor can Arab Neoplatonism have played a role. Byzantine Neoplatonism, however, was prominent in the courtly culture of Rustaveli’s time, and the social and political conditions in Georgia likewise were favorable to the rise of a culture of courtly love. Thus both intellectual and socio-political conditions favored the blooming of courtly love in twelfth-century Georgia.
Worker “Right to Know” in 30-year Retrospect: Did We Get it Right, with What We Know Today?
Authors: O'Reilly James T. 
Published: February 2013

Three decades later, did we negotiators get it right? When in 2007 we passed the 30th anniversary of the first “right to know” workplace disclosure rules, 1 should we who negotiated the rule reflect favorably on what was produced? And which of the competing sides, once labeled Doomsayers or Pollyannas, has been proven correct by the miraculous clarity of hindsight? We who were “present at the creation” of the Occupational Safety & Health Administration (“OSHA”) Hazard Communication Standard2 find the saga a mixture of success, frustration and unmet expectations. This essay offers one player’s historical and policy retrospective, and I draw an ambiguous conclusion about an unsettled controversy.
The Public Health Aspects of Environmental Enforcement
Authors: Craig Robin Kundis 
Published: February 2013

Beyond being an environmental concern, pollution is a public health problem. As a result, enforcement of anti-pollution statutes, such as the Clean Air Act and the Clean Water Act, not only protects the environment, but also furthers fundamental public health goals. Moreover, public health benefits provide politically salient arguments for continuing and even strengthening environmental protection that can counteract any political opposition that can arise as a result of the costs of environmental regulation and compliance to regulated entities and the taxpayers.Thus, it is worth examining the extent to which the Environmental Protection Agency (“EPA”) considers the public health in its environmental enforcement priorities and decisions. Focusing on the Clean Air Act and the Clean Water Act, this Article undertakes such an examination by: (1) outlining the statutory connections between public health considerations and environmental regulation; (2) examining the EPA’s enforcement priorities and guidance; and (3) criticizing the EPA’s presentation of its own enforcement effectiveness over the last decade.This Article concludes that public health considerations do play a significant role in environmental enforcement policies and decisionmaking. However, the EPA’s commitment to presenting the public health benefits of its enforcement actions has varied considerably over the last decade. With the release of its FY2009 enforcement assessment, however, the EPA has both expanded its analysis of the connection between environmental pollution enforcement and public health benefits and created new tools to enhance the transparency of these benefits to the affected public.
The Evolution of NEPA in the Fight Against Climate Change
Authors: Reiley Robert 
Published: February 2013

The National Environmental Policy Act (“NEPA”) is the first environmental charter of the United States. 1 Signed into law on January 1, 1970, NEPA addresses the need for overarching national environmental guidance in the country. During the course of its forty year history, NEPA has been used to challenge a wide range of federal actions including the issuance of operating permits under the Clean Air Act,2 the approval of forest management plans approved under the National Forest Management Act,3 the construction of highways under the Federal-Aid Highways Act,4 and the issuance of oil leases under the Outer Continental Shelf Lands Act.5 Given the breadth of NEPA’s applicability, it was inevitable that NEPA would become a tool to combat climate change. The use of NEPA to require federal agencies to take a “hard look” at greenhouse gas (“GHG”) emissions makes perfect sense because many federal actions directly or indirectly contribute to GHG emissions. Since 1990, in City of Los Angeles v. NHTSA,6 plaintiffs have used NEPA, successfully and unsuccessfully, to challenge federal actions that might have an impact on the global climate.
Web-Based Cognitive Behavioral Treatment for Bulimia Nervosa
Authors: Hartmann Steffen , Timm Christina , Barnow Sven , Rubel Julian A. , Lalk Christopher , Pruessner Luise 
Published: July 2024

ImportanceDespite the existence of effective treatments, many individuals with bulimia nervosa (BN) do not receive evidence-based therapies. Integrating digital interventions into routine care might reach more patients and reduce the clinical burden of BN.ObjectiveTo evaluate the effectiveness of a web-based cognitive behavioral self-help intervention for individuals with BN.Design, Setting, and ParticipantsA 2-group randomized clinical trial without follow-up was conducted between February 2, 2021, and July 9, 2022, in Germany. Participants aged between 18 and 65 years who met the diagnostic criteria for BN were enrolled online via self-referral. Data analyses were conducted from October 24, 2022, to December 23, 2023.InterventionsA web-based cognitive behavioral self-help intervention including 12 weekly modules was compared with a waiting-list control group only having access to routine care.Main Outcomes and MeasuresThe primary outcome was the change in the number of bulimic episodes between baseline and posttreatment. Secondary outcomes included changes in global eating disorder symptoms, clinical impairment, well-being, work capacity, comorbid symptoms, self-esteem, and emotion regulation complemented by weekly measures and ecological momentary assessment. Intention-to-treat analyses were performed.ResultsParticipants (N = 154; mean [SD] age, 29.6 [8.6] years; 149 [96.8%] female) receiving the web-based intervention demonstrated a significantly greater decrease in bulimic episodes compared with the control group (Cohen d = −0.48; 95% CI, −0.75 to −0.20; P &amp;lt; .001), representing a significant change in binge-eating episodes (Cohen d = −0.61; 95% CI, −0.89 to −0.33; P &amp;lt; .001), but not in compensatory behaviors (Cohen d = −0.25; 95% CI, −0.51 to 0.02; P = .21). The intervention was superior in improving global eating disorder symptoms (Cohen d = −0.61; 95% CI, −0.89 to −0.32; P &amp;lt; .001) and clinical impairment (Cohen d = −0.62; 95% CI, −0.92 to −0.33; P &amp;lt; .001). No significant effects were found for well-being (Cohen d = −0.08; 95% CI, −0.37 to 0.22; P &amp;gt; .99) and work capacity (Cohen d = −0.01; 95% CI, −0.68 to 0.66; P = .99). Exploratory analyses indicated significant changes in self-esteem and emotion regulation difficulties, but not in comorbid symptoms.Conclusions and RelevanceIn this randomized clinical trial, a web-based cognitive behavioral self-help intervention effectively decreased eating disorder symptoms and illness-related burden in individuals with BN, underlining the potential of digital interventions to complement established treatments.Trial RegistrationClinicalTrials.gov Identifier: NCT04876196