bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE RELATIONSHIP BETWEEN KNOWLEDGE AND ATTITUDE OF POSYANDU CADRES WITH NUTRITION KIE PRACTICES IN THE WORK AREA OF OELE HEALTH CENTER, ROTE NDAO DISTRICT
Authors: Risca Merlince Isach  , Helga. J.N. Ndun  , Marni Marni  , Christina Rony Nayoan  
Published: August 2024

ABSTRAK
Kader posyandu merupakan ujung tombak dalam pelayanan posyandu, karena kader menjadi kelompok yang sering berinteraksi dengan masyarakat sehingga mempunyai kedudukan yang strategis dan menjadi sarana yang efektif dalam menyampaikan informasi kesehatan. Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan kader dengan praktik KIE gizi dan hubungan antara sikap kader dengan praktik KIE gizi di wilayah kerja Puskesmas Oele, Kabupaten Rote Ndao. Jenis penelitian ini adalah observasional analitik dengan desain penelitian yaitu cross-sectional. Sampel dalam penelitian ini berjumlah 55 orang kader posyandu yang ada pada tujuh desa di Kecamatan Rote Selatan. Teknik analisis data menggunakan uji chi square. Hasil penelitian menunjukkan adanya hubungan yang signifikan antara pengetahuan kader dengan praktik KIE gizi (ρ value = 0,001). Tidak ada hubungan yang signifikan antara sikap kader dengan praktik KIE gizi (ρ value = 0,200). Puskesmas Oele perlu memberikan edukasi gizi dan pelatihan kepada semua kader posyandu untuk meningkatkan pengetahuan dan keterampilan memberikan KIE. Pengetahuan yang meningkat menjadi dasar kader dalam memberikan KIE gizi kepada ibu balita sehingga dapat mengurangi masalah gizi yang ada di Kecamatan Rote Selatan.
ABSTRACT
Cadres (posyandu) are the spearhead of posyandu services, because cadres are a group that often interacts with the community so that they have a strategic position and become an effective means of delivering health information. This study aims to determine the relationship between cadre knowledge and communication, information and nutrion education practies and the relationship between cadre attitude and communication, information and nutrion education practies in the working area of Oele Health Center, Rote Ndao District. This type of research is analytic observational with cross-sectional research design. The sample in this study was 55 posyandu cadres in seven villages in South Rote Subdistrict. Data analysis technique used was chi square test. The results showed a significant relationship between knowladge of cadres and communication, information and nutrion education practice (ρ value = 0.001). There was no significant relationship between cadre attitude and communication, information and nutrion education practice (ρ = 0.200). Oele Health Center needs to provide nutrition-related education and training to all posyandu cadres to improve their knowledge and skills in providing communication, information and nutrion education practies. Increased knowledge becomes the basis for cadres in providing communication, information and nutrion education practies to mothers of children under five so as to reduce nutrition problems in South Rote Subdistrict.
PENGARUH GEN Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) TERHADAP PERKEMBANGAN PENYAKIT KARDIOVASKULAR
Authors: Setiawati Tri , Jumriana  , Rabiatul Adawiyah  , Ryka Marina Walanda  
Published: August 2024

ABSTRAK
Gen PGC-1α sebagai pengatur metabolisme sel, biogenesis mitokondria, mempengaruhi regulasi sel endotel dan sel otot polos yang berkaitan dengan perkembangan penyakit vaskular terutama penyakit aterosklerosis. PGC-1α dapat mengontrol beberapa aspek fungsi otot terkait dengan olahraga, karena PGC-1α dapat mengontrol paralisis otot, menekan respon inflamasi yang luas dan memediasi efek baik akibat olahraga. Peningkatan PGC-1α dapat mencegah dan mempengaruhi regresi lesi penyakit terutama aterosklerosis. Ekspresi PGC-1α yang rendah berhubungan dengan kejadian gagal jantung akibat stres dan kematian sel kardiomiosit. Disfungsi PGC-1α kemungkinan mendasari patologi penyebab berbagai penyakit degerenratif, termasuk kardiovaskular, penyakit degenerasi saraf, dan kanker.

ABSTRACT
Gene of PGC-1α functions as a regulator of cell metabolism, mitochondrial biogenesis, affects the regulation of endothelial cells and smooth muscle cells that are related to the development of vascular diseases, especially atherosclerosis. PGC-1α can control several aspects of muscle function related to exercise, as PGC-1α can control muscle paralysis, suppress extensive inflammatory responses and mediate exercise-induced good effects. Increased PGC-1α may prevent and influence regression of disease lesions especially atherosclerosis, whereas lack of PGC-1α levels are associated with the incidence of stress-induced heart failure and cardiomyocyte cell death. PGC-1α dysfunction likely underlies the causative pathology of various degenerative diseases, including cardiovascular, neurodegenerative diseases, and cancer.
Strategic food reserves storage, safety and risk minimization: Problems and perspectives
Authors: Shahinyan Samvel , Badasyan Ani , Babayan Bella , Melkumyan Marina , Yesayan Tigran , Yesayan Alexander 
Published: August 2024

Background: The hunger problem is a significant issue arising from global challenges in the 21st century. It is a consequence of inadequate food safety and poor strategic food storage. This makes innovations and improvements in these areas particularly crucial, especially for developing countries and regions affected by military conflicts and natural disasters.
Context and purpose of this study: We aimed to study carbonate limestone caves as potentially safe locations for constructing strategic food storage facilities.
Results: The preliminary results from Magellan Cave (Magill Cave) in the Areni region of the Republic of Armenia indicate that the cave has suitable conditions for use as a potential site for strategic food storage, particularly for cereal grains. Biological studies have proved the absence of mesophilic microbes in rock minerals and in soil samples from its inner space. Additionally, psychrophilic microbes, thermophilic algae, and representatives of Cyanobionta were found in waters that meet underground hot springs. Chemical analyses revealed no toxic compounds in the rock minerals, poisonous gases, or radon accumulation. The radiation levels were also found to be safe.
Conclusions: Physical, chemical, and biological research have demonstrated the absence of risk factors for health and food safety in Magellan Cave. No spoilage microbes or human pathogenic bacteria were found. Additionally, no fungi were detected. The results suggest that this cave could be a promising location for constructing underground food storage for strategic reserves.
Keywords: Magellan Cave (Magill cave), underground constructions, food strategic reserve storage, biological safety, spoilage, psychrophilic microbes
Cognitive Outcomes in Autosomal-Dominant Alzheimer’s Disease: A Comprehensive Review from a Colombian Kindred with the Presenilin-1 E280A Mutation
Authors: Giudicessi Averi , McDowell Celina Pluim , Martinez Jairo E. , Baena Ana , Vila-Castelar Clara , Norton Daniel , Aguirre-Acevedo Daniel C. , Tirado Victoria , Bocanegra Yamile , Guzman-Velez Edmarie , Lopera Francisco , Cronin-Golomb Alice , Quiroz Yakeel T. 
Published: August 2024

Background: The largest identified kindred worldwide with a single mutation causing autosomal-dominant Alzheimer’s disease (ADAD) is a family from Antioquia, Colombia, carrying the Presenilin-1 ( PSEN1) E280A (Paisa) mutation. The majority of mutation carriers develop dementia, typically commencing in their late 30 s, with a median onset age of 49 years. Cognitive decline is a hallmark feature. Objective: This review synthesizes the existing literature on neuropsychological assessments in PSEN1 E280A mutation carriers throughout their lifespan. We provide a comprehensive overview of cognitive outcomes in this unique population. Methods: We reviewed and integrated the published research, analyzing studies on neuropsychological assessments in PSEN1 E280A carriers. Our focus was on measures of verbal, semantic, episodic, and spatial memory, and encompassed other cognitive domains such as language, attention, visuospatial memory, and executive functioning. Results: Verbal, semantic, episodic, and spatial memory emerged as the most sensitive indicators of preclinical changes in PSEN1 E280A carriers. Inconsistencies were noted in findings from tests assessing language, attention, visuospatial memory, and executive functioning, suggesting potential limitations in detecting early cognitive changes in PSEN1 mutation carriers. Specific cognitive tasks developed for this population proved effective but underutilized. Conclusions: The review underscores the importance of continued test development tailored to detect early cognitive changes in PSEN1 E280A carriers, potentially enhancing ADAD screening. Furthermore, investigating ADAD mutations in children may identify early changes in AD and enhance our understanding of neuropsychological functioning across the lifespan. This synthesis provides valuable insights for researchers, clinicians, and policymakers engaged in the study and management of ADAD.
Degradation of Amyloid-β Species by Multi-Copper Oxidases
Authors: Yang Jing , Ran Kathleen , Ma Wenzhe , Chen Yanshi , Chen Yanxin , Zhang Can , Ye Hui , Lu Ying , Ran Chongzhao 
Published: August 2024

Background: Reduction of the production of amyloid-β (Aβ) species has been intensively investigated as potential therapeutic approaches for Alzheimer’s disease (AD). However, the degradation of Aβ species, another potential beneficial approach, has been far less explored. Objective: To investigate the potential of multi-copper oxidases (MCOs) in degrading Aβ peptides and their potential benefits for AD treatment. Methods: We investigated the degradation efficiency of MCOs by using electrophoresis and validated the ceruloplasmin (CP)-Aβ interaction using total internal reflection fluorescence microscopy, fluorescence photometer, and fluorescence polarization measurement. We also investigated the therapeutic effect of ascorbate oxidase (AO) by using induced pluripotent stem (iPS) neuron cells and electrophysiological analysis with brain slices. Results: We discovered that CP, an important MCO in human blood, could degrade Aβ peptides. We also found that other MCOs could induce Aβ degradation as well. Remarkably, we revealed that AO had the strongest degrading effect among the tested MCOs. Using iPS neuron cells, we observed that AO could rescue neuron toxicity which induced by Aβ oligomers. In addition, our electrophysiological analysis with brain slices suggested that AO could prevent an Aβ-induced deficit in synaptic transmission in the hippocampus. Conclusions: To the best of our knowledge, our report is the first to demonstrate that MCOs have a degrading function for peptides/proteins. Further investigations are warranted to explore the possible benefits of MCOs for future AD treatment.
The Association Between Distinct Delusional Ideations and Depressive Symptoms in Alzheimer’s Disease: A Re-Analysis of CATIE-AD
Authors: Nagata Tomoyuki , Nakajima Shinichiro , Kito Shinsuke , Shinagawa Shunichiro 
Published: August 2024

Background: Delusional ideations, one of neuropsychiatric symptoms (NPSs), are frequently shown in the long-term progression of Alzheimer’s disease (AD), and comorbid with other NPSs including depression or agitation. Despite various types of delusional ideations, the comorbidity between each delusional ideation and depressive symptoms has not been discussed. Objective: The present cross-sectional study is aimed at testing the hypothetical mechanism of comorbid pattern in AD. Methods: Among 421 patients with AD, we analyzed the dataset of the Clinical Antipsychotic Trials of Intervention Effectiveness–Alzheimer’s Disease to compare age, sex, racial type, Mini-Mental State Examination (MMSE) scores, and Neuropsychiatric Inventory (NPI) depression score of between the presence and absence of each delusional ideation (delusion of persecution, theft, jealousy, abandonment, phantom boarder, Capgras syndrome, misidentification of place, or television sign). Next, with the stratification based on MMSE score of < or > = 15 points, we further explored association between delusional ideation and depressive symptom that was found significances in the primary analysis Results: Among eight subtypes of delusional ideations, depression score was higher in those with persecution delusion or Capgras syndrome. Moreover, the Capgras syndrome was associated with presence of depression in severer global cognitive impairment status. Conclusions: As comorbid NPSs of delusional ideation in AD, depressive severity is associated with specific delusional subtype: persecution delusion and Capgras syndrome. Capgras syndrome may be attributable to severe cognitive impairment in addition to depressive symptom. The consideration of pathogenetic differences in the distinct delusional ideations may be helpful for clinicians to select the treatment strategy.
Pengaturan Asas Cepat, Sederhana Dan Biaya Ringan Dalam Hukum Acara Perdata dan Hukum Acara Pidana
Authors: Navisa Fitria Dewi 
Published: August 2024

AbstrakAsas peradilan cepat, sederhana dan biaya ringan menjawab keinginan masyarakat dan para pencari keadilan menuntut agar penyelesaian perkara melalui pengadilan berjalan sesuai dengan asas tersebut. Secara teoritis asas ini mengatur agar hambatan tidak terjadi di masyarakat, namun pada praktiknya penerapan asas ini sukar ditemukan. Dengan demikian, penilitian ini mengkaji bagaimana penerapan asas peradilan cepat dan biaya ringan dalam proses perkara perdata, dan apa perbedaan penerapan asas peradilan cepat, sederhana dan biaya ringan dalam hukum acara pidana. Dalam penelitian ini penulis menggunakan teori-teori hukum tertentu sebagai landasan analisa untuk menemukan jawaban atas permasalahan. Teori yang digunakan yaitu; Teori Kepastian Hukum, dan Teori Kemanfaatan Hukum. Metode pendekatan yang digunakan bersifat normatif, 2 macam pendekatan yang digunakan yakni pendekatan perundang-undangan (statute approach) dan pendekatan konseptual (Conseptual Approach). Asas peradilan cepat sederhana dan biaya ringan adalah salah satu dasar pijakan bagi setiap lembaga peradilan yang menyelesaikan perkara, baik itu perkara perdata ataupun perkara pidana. Penerapan asas cepat sederhana dan biaya ringan ini dibuktikan dengan tenggang waktu upaya hukum, pengabungan perkara, dan bebas biaya perkara bagi masyarakat yang tidak mampu. Hal ini dilakukan demi terwujudnya kepastian hukum yang berkeadilan.Kata kunci : Asas, hukum acara perdata, peradilan
PERLINDUNGAN HUKUM BAGI BURUH YANG MENGALAMI KECELAKAAN KERJA MENURUT UNDANG-UNDANG NO. 13 Tahun 2003
Authors: Maulidin Adinda Farah 
Published: August 2024

Abstrak Abstrak Perlindungan terhadap tenaga kerja dimaksudkan untuk menjamin hak-hak dasar pekerja dan menjamin kesamaan serta perlakuan tanpa diskriminasi atas dasar apapun untuk mewujudkan kesejahteraan pekerja dan keluarganya dengan tetap memperhatikan perkembangan kemajuan dunia usaha dan kepentingan pengusaha. Kecelakaan kerja merupakan salah satu permasalahan yang sering terjadi pada pekerja di perusahaan. Rumusan masalah yang akan menjadi pembahasan dalam penelitian adalah Apakah yang menjadi kewajiban pengusaha terhadap pekerja yang mengalami kecelakaan kerja menurut UU Nomor 13 Tahun 2003. Bagaimana pelaksanaan perlindungan hukum serta pertanggungjawaban terhadap jaminan keselamatan dan kesehatan bagi buruh/pekerja pada Studi Kasus Putusan PN Banjarmasin Nomor 23/Pdt.sus-PHI/2020/PN Banjarmasin Menurut UU Nomor 13 Tahun 2003. Penelitian ini bertujuan untuk memahami perlindungan hukum yang diterapkan terhadap buruh yang mengalami kecelakaan kerja pada putusan Nomor 23/Pdt.sus-PHI/2020/PN Banjarmasin dan mengetahui tanggung jawab perusahaan terhadap buruh yang mengalami kecelakaan kerja pada putusan Nomor 23/Pdt.sus-PHI/2020/PN Banjarmasin. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian hukum yang bersifat yuridis normatif. Penelitian yuridis normatif yaitu dengan melakukan penelitian terhadap sumber-sumber tertulis meliputi penelitian terhadap sumber-sumber hukum, peraturan perundang-undangan, dan buku tentang perlindungan hukum terhadap tenaga kerja Indonesia. Teknik pengumpulan data dilakukan dengan cara penelitian kepustakaan (Library Research). Hasil penelitian adalah Apabila pekerja mengalami kecelakaan kerja berhak menerima santunan berupa uang dan biaya pengobatan dari PT. JAMSOSTEK atau dari pengusaha jika belum terdaftar sebagai peserta Jamsostek . Selanjutnya mengenai ganti rugi dalam hubungannya dengan tenaga kerja yang wajib diberikan oleh perusahaan adalah memberikan hak-hak pekerja seperti yang diatur dalam Pasal 9 UU No. 3 Tahun 1992 dan UU No.14 tahun 1993 Tentang Penyelenggaraan Program Jaminan Sosial Tenaga Kerja. Kesimpulan dari penelitian adalah mengenai masalah keselamatan dan kesehatan berdasarkan Studi Kasus Putusan No.23/Pdt.sus-PHI/2020/PN Banjarmasin bahwa pekerja yang mengalami kecelakaan kerja harus membuktikan bahwa kecelakaan tersebut terjadi karena kesalahan pengusaha atau kelalaian pengusaha. Kata Kunci : Kecelakaan Kerja, Perlindungan, Buruh
Tinjauan Hukum Internacional Terhadap Putusan Makamah Internacional(International Court Of Justice)Tentang Senketa Maritim Antara Somalia Dan Kenya
Authors: Freitas Joel Antonio 
Published: August 2024

Penelitian ini bertujuan untuk (1) menganalisis awal mula sengketa maritim antara Kenya dan Somalia (2) untuk mengetahui upaya penyelesaian sengketa maritim antara Kenya dan Somalia dalam perspektif hukum internasional. Kedua negara telah mengalami sengketa maritim atas batas laut lebih dari 100.000 km persegi dasar laut di perairan Samudera Hindia. Mereka mulai bersengketa setelah Somalia menuduh Kenya secara ilegal memberikan hak eksplorasi sumber daya di perairan kepada perusahaan multinasional Total dan Eni. Seperti yang telah dinyatakan oleh Kenya, perairan di lepas Pantai Afrika Timur adalah salah satu prospek eksplorasi minyak terpanas di dunia dan daerah yang diperebutkan memiliki cadangan hidrokarbon. Metode penelitian yang digunakan adalah penelitian hukum normatif. Sedangkan sifat penelitian ini adalah deskriptif kualitatif dengan teknik pengumpulan data dengan melakukan studi kepustakaan. Hasil penelitian menunjukkan bahwa sengketa batas laut telah memperburuk hubungan diplomatik antara Kenya dan Somalia yang sebenarnya harus dihindari oleh kedua negara. Sebelum membawa kasus ini ke Mahkamah Internasional (ICJ), kedua negara sepakat untuk menyelesaikan sengketa melalui negosiasi bilateral, namun kasus tersebut masih belum terselesaikan. Oleh karena itu, Somalia memutuskan untuk membawa kasus ini ke Pengadilan.
Вплив зміни комбінацій параметрів виготовлення за технологією СЛП елементів основне тіло - пост-кордон – кордон на суцільність та шорсткість зразків
Authors: Adjamskiy Sergey , Kononenko Ganna , Podolskyi Rostyslav , Baduk Sergey 
Published: August 2024

Recently, the production of metal products has become more adaptable and rapid because of the use of 3-D technologies based on layer-by-layer manufacturing. The quality of products produced using selective laser melting (SLP technology) depends on many factors, which can be divided into main groups: equipment, materials, processes, details, and finishing. To ensure high-quality products, a systematic approach is necessary. Subject of research. Patterns of influence of changes in combinations of the main parameters of the manufacturing process (scanning strategy, distance between tracks, specific power of the process, scanning speed, power) of various elements (main body, border, post-border) of products manufactured using SLP technology on their quality (integrity and surface roughness). Purpose. Development of recommendations for border and post-border printing modes for 316L stainless steel with a layer thickness of 30 μm at different distances between tracks and with varying laser beam scanning speeds. Methods. For research purposes, samples of 10×10×5 mm were prepared using SLP technology from AISI 316L austenitic steel powder. The main body of the test samples was produced with constant parameters: layer thickness 30 μm, power 100 W, scanning speed, 1700 mm/s; distance between tracks, 0.05 mm; calculated specific energy density is 39.21 J/mm3, continuity ~ 99, 9%. The test samples of groups A, B, and C differed according to the scanning strategy (Out2In or In2Out) and the distance between the boundary tracks. Test samples of groups D, E, and F were made with constant power parameters of 100 W and the distance between the border tracks of 0.05 mm and with variable scanning speed parameters for group D 2.6...1.75 m/s; for group E 2.6...1.55 m/s; for group F 3.0...1.55 m/s. Samples were printed on an Alfa-150 3D printer by ALT Ukraine LLC. Etching of the structure was carried out in Kalling’s solution, and analysis of the microstructure was carried out using an AxioVert 200MMat optical microscope. Roughness control was performed using BioBase 220R with a constant control zone of 1.25 mm. Results. It was established that the borders of samples of groups A and C printed in the range of specific energy density ≈27-33 J/mm3 have thin borders that do not protrude and have no visible deviations. Roughness control showed that test samples A3, A4, C4, D5, E1, E2, and F6 had roughness values in the range of 9.7...11.2 microns. When comparing the obtained data with the manufacturing parameters and microstructure analysis, it was established that to achieve high continuity with minimal roughness in the finished products on the surface, it is necessary to apply the parameters in such a way that the post-contour manufacturing parameters energetically fluctuate in the range of ± 4 J/mm3 from the specific energy density main body.
PENGARUH CAMPURAN BAHAN BAKAR ETHANOL BENSIN TERHADAP KONSUMSI BAHAN BAKAR DAN EMISI GAS BUANG PADA KENDARAAN BERMOTOR 125 CC SISTEM INJEKSI
Authors: Rifal Mohamad 
Published: August 2024

Pertumbuhan kendaraan bermotor di Indonesia saat ini telah mencapai lebih dari 10 % per tahun dan menjadi faktor dominan penyebab utama naiknya angka pencemaran udara. Salah satu cara untuk mereduksi emisi gas bunag dan konsumsi bahan bakar minyak (fosil) yaitu dengan menggunakan bahan bakar alternatih yang ramah lingkungan contohnya etanol. Secara teorotis, etanol memiliki angka oktan lebih tinggi berkisar 117 RON, dan bila dibandingkan dengan bensin ( gasoline ) yang mempunyai RON hanya 88,dan diharapkan apabila bahan bakar bensin dicampur dengan etanol emisi gas buang yang keluar dari kendaraan lebih baik dari penggunaan bahan bakar bensin. Tujuan dari penelitian ini adalah untuk mengetahui efek deri campuran bahan bakar ethanol-bensin terhadap konsumsi bahan bakar, dan emisi gas buang.Penelitian ini menggunakan kendaraan roda dua dengan tipe mesin air cooled 4-stroke SOHC, 1 silinder 125 cc dengan sistem injeksi. Kenderaan uji dioperasikan diatas chassis dynamometer. Pengukuran emisi gas buang dilakukan menggunakan gas analyzer Sukyoung SY-GA501. Variasi campuran bahan bakar yang diuji yaitu E10, E20, dan E30 dan variasi kecepatan yaitu 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000, 5500, 6000, 6500. Hasil penelitian menujukan bahwa penggunaan bahan bakar campuran E20 adalah campuran terbaik dibandingkan dengan bensin murni, dimana komsumsi bahan bakar untuk E20 14% lebih rendah dari bensin murni. Emisi HC, CO dan CO2 dari hasil pengujian pada kondisi idle maisng masing sebesar 13 %, 45% dan 39% dibandingkan dengan bensin murni.