bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxyethyl starch 130/0.4 versus modified succinylated gelatin for volume expansion in pediatric cardiac surgery patients: the effects on perioperative bleeding and transfusion needs
Authors: MULAVISALA KRISHNA PRASAD , KULKARNI VENUGOPAL , MUDUNURI RAVIKIRAN , VISWANATH VOLETI VENKATA RAJA , BYALAL JAGANNATH R. , GOPAL PALEPU B. , KULKARNI SADANAND S. 
Published: August 2012

SUMMARYVolume therapy and maintenance of stable hemodynamics is crucial in children undergoing cardiac surgery on cardiopulmonary bypass (CPB). The clinical use of hydroxyethyl starch (HES) 130/0.4 is limited by the possibility of adverse hemostatic effects which could potentially increase the risk of perioperative bleeding and transfusion requirements. We conducted this study to evaluate the safety and efficacy of HES in comparison with modified succinylated gelatin (MSG). Forty‐nine children were randomly assigned to receive either HES (n = 28) or MSG (n = 21) during the pre‐bypass period. Coagulation was assessed with thromboelastography (TEG) and the transfusion requirements up to the first postoperative day were documented. Both groups were comparable with respect to age, weight, CPB duration as well as hematological and biochemical laboratory investigations. TEG parameters were not deranged up to the first postoperative period in either group and there was a trend of reduced blood loss and transfusion requirements in HES groups although there was no statistically significant difference. Our study shows that HES 130/0.4 is safe and effective for volume replacement in pediatric cardiac surgery patients.
Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-l-glutamate for Imaging xC− Transporter Using Positron Emission Tomography in Patients with Non–Small Cell Lung or Breast Cancer
Authors: Baek Sora , Choi Chang-Min , Ahn Sei Hyun , Lee Jong Won , Gong Gyungyub , Ryu Jin-Sook , Oh Seung Jun , Bacher-Stier Claudia , Fels Lüder , Koglin Norman , Hultsch Christina , Schatz Christoph A. , Dinkelborg Ludger M. , Mittra Erik S. , Gambhir Sanjiv S. , Moon Dae Hyuk 
Published: August 2012

Abstract
Purpose: (4S)-4-(3-[18F]fluoropropyl)-l-glutamate (BAY 94-9392, alias [18F]FSPG) is a new tracer to image xC− transporter activity with positron emission tomography (PET). We aimed to explore the tumor detection rate of [18F]FSPG in patients relative to 2-[18F]fluoro-2-deoxyglucose ([18F]FDG). The correlation of [18F]FSPG uptake with immunohistochemical expression of xC− transporter and CD44, which stabilizes the xCT subunit of system xC−, was also analyzed.
Experimental Design: Patients with non–small cell lung cancer (NSCLC, n = 10) or breast cancer (n = 5) who had a positive [18F]FDG uptake were included in this exploratory study. PET images were acquired following injection of approximately 300 MBq [18F]FSPG. Immunohistochemistry was done using xCT- and CD44-specific antibody.
Results: [18F]FSPG PET showed high uptake in the kidney and pancreas with rapid blood clearance. [18F]FSPG identified all 10 NSCLC and three of the five breast cancer lesions that were confirmed by pathology. [18F]FSPG detected 59 of 67 (88%) [18F]FDG lesions in NSCLC, and 30 of 73 (41%) in breast cancer. Seven lesions were additionally detected only on [18F]FSPG in NSCLC. The tumor-to-blood pool standardized uptake value (SUV) ratio was not significantly different from that of [18F]FDG in NSCLC; however, in breast cancer, it was significantly lower (P &lt; 0.05). The maximum SUV of [18F]FSPG correlated significantly with the intensity of immunohistochemical staining of xC− transporter and CD44 (P &lt; 0.01).
Conclusions: [18F]FSPG seems to be a promising tracer with a relatively high cancer detection rate in patients with NSCLC. [18F]FSPG PET may assess xC− transporter activity in patients with cancer. Clin Cancer Res; 18(19); 5427–37. ©2012 AACR.
Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms
Authors: Ghesquières Hervé , Cartron Guillaume , Seymour John Francis , Delfau-Larue Marie-Hélène , Offner Fritz , Soubeyran Pierre , Perrot Aurore , Brice Pauline , Bouabdallah Réda , Sonet Anne , Dupuis Jehan , Casasnovas Olivier , Catalano John Vincent , Delmer Alain , Jardin Fabrice , Verney Aurélie , Dartigues Peggy , Salles Gilles 
Published: August 2012

Abstract
In patients with follicular lymphoma treated with single-agent rituximab, single nucleotide polymorphisms in the FCGR3A gene are known to influence response and progression-free survival. The prognostic role of FCGR3A and FCGR2A polymorphisms in patients with follicular lymphoma treated with rituximab and chemotherapy combination remains controversial and has not been evaluated in the context of rituximab maintenance. FCGR3A and FCGR2A single nucleotide polymorphisms were evaluated in, respectively, 460 and 455 patients treated in the PRIMA study to investigate whether these were associated with response rate and patient outcome after rituximab chemotherapy induction and 2-year rituximab maintenance. In this representative patient cohort, complete and unconfirmed complete responses after rituximab chemotherapy were observed in 65%, 67%, 66% (P = .86) and 60%, 72%, 66% (P = .21) of FCGR3A VV, VF, FF and FCGR2A HH, HR, RR carriers, respectively. After 2 years of rituximab maintenance (or observation), response rates did not differ among the different genotypes. Progression-free survival measured from either treatment initiation or randomization to observation or maintenance was not influenced by these polymorphisms. These data indicate that FCGR3A and FCGR2A polymorphisms do not influence response rate and outcome when rituximab is combined with chemotherapy or used as maintenance treatment. The PRIMA study is registered at www.clinicaltrials.gov as NCT00140582.
Forty years of increasing suicide mortality in Poland: Undercounting amidst a hanging epidemic?
Authors: Höfer Peter , Rockett Ian R H , Värnik Peeter , Etzersdorfer Elmar , Kapusta Nestor D 
Published: August 2012

AbstractBackgroundSuicide rate trends for Poland, one of the most populous countries in Europe, are not well documented. Moreover, the quality of the official Polish suicide statistics is unknown and requires in-depth investigation.MethodsPopulation and mortality data disaggregated by sex, age, manner, and cause were obtained from the Polish Central Statistics Office for the period 1970-2009. Suicides and deaths categorized as ‘undetermined injury intent,’ ‘unknown causes,’ and ‘unintentional poisonings’ were analyzed to estimate the reliability and sensitivity of suicide certification in Poland over three periods covered by ICD-8, ICD-9 and ICD-10, respectively. Time trends were assessed by the Spearman test for trend.ResultsThe official suicide rate increased by 51.3% in Poland between 1970 and 2009. There was an increasing excess suicide rate for males, culminating in a male-to-female ratio of 7:1. The dominant method, hanging, comprised 90% of all suicides by 2009. Factoring in deaths of undetermined intent only, estimated sensitivity of suicide certification was 77% overall, but lower for females than males. Not increasing linearly with age, the suicide rate peaked at ages 40-54 years.ConclusionThe suicide rate is increasing in Poland, which calls for a national prevention initiative. Hangings are the predominant suicide method based on official registration. However, suicide among females appears grossly underestimated given their lower estimated sensitivity of suicide certification, greater use of “soft” suicide methods, and the very high 7:1 male-to-female rate ratio. Changes in the ICD classification system resulted in a temporary suicide data blackout in 1980-1982, and significant modifications of the death categories of senility and unknown causes, after 1997, suggest the need for data quality surveillance.
No evidence of a death-like function for species B1 human adenovirus type 3 E3-9K during A549 cell line infection
Authors: Frietze Kathryn M , Campos Samuel K , Kajon Adriana E 
Published: August 2012

Abstract

Background
Subspecies B1 human adenoviruses (HAdV-B1) are prevalent respiratory pathogens. Compared to their species C (HAdV-C) counterparts, relatively little work has been devoted to the characterization of their unique molecular biology. The early region 3 (E3) transcription unit is an interesting target for future efforts because of its species-specific diversity in genetic content among adenoviruses. This diversity is particularly significant for the subset of E3-encoded products that are membrane glycoproteins and may account for the distinct pathobiology of the different human adenovirus species. In order to understand the role of HAdV-B-specific genes in viral pathogenesis, we initiated the characterization of unique E3 genes. As a continuation of our efforts to define the function encoded in the highly polymorphic ORF E3-10.9K and testing the hypothesis that the E3-10.9K protein orthologs with a hydrophobic domain contribute to the efficient release of viral progeny, we generated HAdV-3 mutant viruses unable to express E3-10.9K ortholog E3-9K and examined their ability to grow, disseminate, and egress in cell culture.

Results
No differences were observed in the kinetics of infected cell death, and virus progeny release or in the plaque size and dissemination phenotypes between cells infected with HAdV-3 E3-9K mutants or the parental virus. The ectopic expression of E3-10.9K orthologs with a hydrophobic domain did not compromise cell viability.

Conclusions
Our data show that despite the remarkable similarities with HAdV-C E3-11.6K, HAdV-B1 ORF E3-10.9K does not encode a product with a “death-like” biological activity.
Prognostic impact of circulating tumor cells assessed with the CellSearch System™ and AdnaTest Breast™ in metastatic breast cancer patients: the DETECT study
Authors: Müller Volkmar , Riethdorf Sabine , Rack Brigitte , Janni Wolfgang , Fasching Peter A , Solomayer Erich , Aktas Bahriye , Kasimir-Bauer Sabine , Pantel Klaus , Fehm Tanja 
Published: August 2012

Abstract
Introduction
There is a multitude of assays for the detection of circulating tumor cells (CTCs) but a very limited number of studies comparing the clinical relevance of results obtained with different test methods. The DETECT trial for metastatic breast cancer patients was designed to directly compare the prognostic impact of two commercially available CTC assays that are prominent representatives of immunocytochemical and RT-PCR based technologies.

Methods
In total, 254 metastatic breast cancer patients were enrolled in this prospective multicenter trial. CTCs were assessed using both the AdnaTest Breast Cancer and the CellSearch system according to the manufacturers' instructions.

Results
With the CellSearch system, 116 of 221 (50%) evaluable patients were CTC-positive based on a cut-off level at 5 or more CTCs. The median overall survival (OS) was 18.1 months in CTC-positive patients. (95%-CI: 15.1-22.1 months) compared to 27 months in CTC-negative patients (23.5-30.7 months; p<0.001). This prognostic impact for OS was also significant in the subgroups of patients with triple negative, HER2-positive and hormone receptor-positive/HER2-negative primary tumors. The progression free survival (PFS) was not correlated with CTC status in our cohort receiving different types and lines of systemic treatment (p = 0.197). In multivariate analysis, the presence of CTCs was an independent predictor for OS (HR: 2.7, 95%-CI: 1.6-4.2). When the AdnaTest Breast was performed, 88 of 221 (40%) patients were CTC-positive. CTC-positivity assessed by the AdnaTest Breast had no association with PFS or OS.

Conclusions
The prognostic relevance of CTC detection in metastatic breast cancer patients depends on the test method. The present results indicate that the CellSearch system is superior to the AdnaTest Breast Cancer in predicting clinical outcome in advanced breast cancer.

Trial registration
Current Controlled Trials Registry number ISRCTN59722891.
Effects of Radiation on Nuclear Materials: 25th Volume
Authors: Yamamoto Takuya 
Published: August 2012

Description
Seventeen peer-reviewed papers focus on the latest research on the effects of radiation on nuclear materials. These papers focus on:
Light Water Reactor Sustainability Issues and Programs that address the multiple challenges of extended reactor life, including detailed coverage of irradiation embrittlement of reactor pressure vessel steels.
Synergistic Effects of Gas Atoms (i.e. helium and hydrogen) and Displacement Damage, with an emphasis on the unprecedented challenge to structural and plasma-facing materials in nuclear fusion reactors.
Sections cover
Adjunctive Treatment with Gabapentin in Bipolar Patients during Acute Mania
Authors: Astaneh Ali Nazeri , Rezaei Omid 
Published: August 2012

Objective: In this clinical trial, we studied the effects of adjunctive treatment with gabapentin in controlling the symptoms of acute mania in patients admitted with bipolar disorder. Method: Sixty patients with bipolar disorder (30 men and 30 women) admitted in the acute phase of mania were categorized as case and control groups, each holding 30 patients. Both groups were treated with lithium for 6 weeks and the case group received an adjunctive treatment with 900 mg gabapentin simultaneously. All patients were evaluated at the beginning and the end of the trial using Young's Mania Rating Scale (YMRS), and two groups were compared for improvement in acute symptoms. Findings: The final score of YMRS was significantly improved in the case group compared to the control group ( p = 0.00). The improvement of YMRS score was not significantly different between men and women and between different age groups. Conclusion: Adjunctive treatment with gabapentin is effective for controlling symptoms of acute mania.
Comparison of Coordinates of Polref - the First Order Polish National Network - Obtained from Campaigns in 1994/95 and 2008/2010
Authors: Jaworski Leszek , Swiatek Anna 
Published: August 2012

Comparison of Coordinates of Polref - the First Order Polish National Network - Obtained from Campaigns in 1994/95 and 2008/2010
The integration of ASG-EUPOS network with the national first order networks was prepared in two measurement campaigns carried out in 2008 and 2010/2011. The measurements included a total of 340 points of POLREF - the first order national GNSS network. That set of data gives the possibility for comparison of solutions prepared for comprehensive analysis of the points' position and coordinates changes in the long term. Because the results of POLREF were not published the paper includes a brief description of campaigns from 1994 and 1995 and prepared solutions as well as the results of coordinates comparison with campaigns 2008 and 2010/2011. For points of significant deviations in coordinates the analysis of causes was presented.
Statistical View on Phase and Magnitude Information in Signal Processing
Authors: Popiński Waldemar 
Published: August 2012

Statistical View on Phase and Magnitude Information in Signal ProcessingIn this work the problem of reconstruction of an original complex-valued signalot,t= 0, 1, …,n- 1, from its Discrete Fourier Transform (DFT) spectrum corrupted by random fluctuations of magnitude and/or phase is investigated. It is assumed that the magnitude and/or phase of discrete spectrum values are distorted by realizations of uncorrelated random variables. The obtained results of analysis of signal reconstruction from such distorted DFT spectra concern derivation of the expected values and bounds on variances of the reconstructed signal at the observation moments. It is shown that the considered random distortions in general entail change in magnitude and/or phase of the reconstructed signal expected values, which together with imposed random deviations with finite variances can blur the similarity to the original signal. The effect of analogous random amplitude and/or phase distortions of a complex valued time domain signal on band pass filtration of distorted signal is also investigated.
Shock veins in the Sahara 02500 ordinary chondrite
Authors: Owocki Krzysztof , Muszyński Andrzej 
Published: August 2012

Shock veins in the Sahara 02500 ordinary chondriteA specimen of the Sahara 02500 ordinary chondrite contains shock-produced veins consisting of recrystallised fine-grained pyroxenes that include small droplets of Ni-rich metal. Non-melted olivines and pyroxenes show planar deformations filled by shock-melted and -polluted metal and troilite. Shock-melted feldspathic glass is present close to the shock veins. Geothermometric estimations indicate that the meteorite locally experienced moderate shock metamorphism with a minimum local peak temperature above 1400°C, resulting in partial melting of Ca-poor pyroxene and full melting of feldspars, metal and sulphides. The mineral assemblage in the shock veins suggests a pressure during melt recrystallisation below 10 GPa.
Palaeontology of the Middle Turonian limestones of the Nysa Kłodzka Graben (Sudetes, SW Poland): biostratigraphical and palaeogeographical implications
Authors: Chrząstek Alina 
Published: August 2012

Palaeontology of the Middle Turonian limestones of the Nysa Kłodzka Graben (Sudetes, SW Poland): biostratigraphical and palaeogeographical implicationsThe ammonitesLewesiceras peramplumMantell and?Lewesicerassp. are reported from the Upper Cretaceous in the Nysa Kłodzka Graben; they date from the Middle Turonian and ?Coniacian, respectively. The Middle Turonian limestones of the Stara Bystrzyca quarry contain an abundant assemblage of inoceramids (Inoceramus cuvieriSowerby and I. lamarcki Parkinson) and other bivalves, including oysters, as well as brachiopods and trace fossils. Micropalaeontological data show the presence of foraminifers and siliceous sponge spiculae, bryozoans, ostracods and fragments of bivalves and gastropods. The Middle Turonian calcareous deposits belongs to the upper part of theInoceramus lamarckiZone (late Middle Turonian) and were deposited on a shallow, subtidal offshore shelf. They overlie the Middle Turonian Bystrzyca and Długopole Sandstones, which represent foreshore-shoreface delta deposits. The fossil assemblage suggests a moderate- to low-energy, normal-salinity environment with occasionally an oxygen deficit.
Reflection of Plane Waves in a Rotating Transversly Isotropic Magneto-Thermoelastic Solid Half-Space
Authors: Singh Baljeet , Yadav Anand 
Published: August 2012

Reflection of Plane Waves in a Rotating Transversly Isotropic Magneto-Thermoelastic Solid Half-SpaceThe governing equations of a rotating transversely isotropic magneto-thermoelastic medium are solved to obtain the velocity equation, which indicates the existence of three quasi plane waves. Reflection of these plane waves from a stress-free thermally insulated surface is studied to obtain the reflection coefficients of various reflected waves. The effects of anisotropy, rotation, thermal and magnetic fields are shown graphically on these coefficients.
Sermon-Writing Women:
Authors: Patricia Stoop 
Published: August 2012

ABSTRACT
On December 8, 1459, Maria van Pee, canoness regular in the Brussels convent of Jericho, decided to write down the sermon that she heard her confessor, Jan Storm, deliver in the convent's church. Her initiative laid the foundation for a long and carefully maintained tradition of sermon writing, which would endure until the beginning of the eighteenth century. After providing a short historical background, this article focuses on the convent's literary production and especially on the sermon collections and their prologues in which the female scribes account for their contribution to the writing and editing of the sermons and the composition of the manuscripts. By concentrating on the collection of Maria van Pee, it demonstrates how the sisters handled the sermons they heard their confessors preach in order to keep them from oblivion and how they thereby designed a creative and collective “authorship” for themselves, a role that was unusual for the Middle Ages.
Comparison of No-Test Telehealth and In-Person Medication Abortion
Authors: Ralph Lauren J. , Baba C. Finley , Biggs M. Antonia , McNicholas Colleen , Hagstrom Miller Amy , Grossman Daniel 
Published: June 2024

ImportanceIn the US, access to medication abortion using history-based (no-test) eligibility assessment, including through telehealth and mailing of mifepristone, has grown rapidly. Additional evidence on the effectiveness and safety of these models is needed.ObjectiveTo evaluate whether medication abortion with no-test eligibility assessment and mailing of medications is as effective as in-person care with ultrasonography and safe overall.Design, Setting, and ParticipantsProspective, observational study with noninferiority analysis. Sites included 4 abortion-providing organizations in Colorado, Illinois, Maryland, Minnesota, Virginia, and Washington from May 2021 to March 2023. Eligible patients were seeking medication abortion up to and including 70 days’ gestation, spoke English or Spanish, and were aged 15 years or older.ExposureStudy groups reflected the model of care selected by the patient and clinicians and included: (1) no-test (telehealth) eligibility assessment and mailing of medications (no-test + mail) (n = 228); (2) no-test eligibility assessment and pickup of medications (no-test + pickup) (n = 119); or (3) in-person with ultrasonography (n = 238).Main Outcomes and MeasuresEffectiveness, defined as a complete abortion without the need for repeating the mifepristone and misoprostol regimen or a follow-up procedure, and safety, defined as an abortion-related serious adverse event, including overnight hospital admission, surgery, or blood transfusion. Outcomes were derived from patient surveys and medical records. Primary analysis focused on the comparison of the no-test + mail group with the in-person with ultrasonography group.ResultsThe mean age of the participants (N = 585) was 27.3 years; most identified as non-Hispanic White (48.6%) or non-Hispanic Black (28.1%). Median (IQR) gestational duration was 45 days (39-53) and comparable between study groups (P = .30). Outcome data were available for 91.8% of participants. Overall effectiveness was 94.4% (95% CI, 90.7%-99.2%) in the no-test + mail group and 93.3% (95% CI, 88.3%-98.2%) in the in-person with ultrasonography group in adjusted models (adjusted risk difference, 1.2 [95% CI, −4.1 to 6.4]), meeting the prespecified 5% noninferiority margin. Serious adverse events included overnight hospitalization (n = 4), blood transfusion (n = 2), and emergency surgery (n = 1) and were reported by 1.1% (95% CI, 0.4%-2.4%) of participants, with 3 in the no-test + mail group, 3 in the in-person with ultrasonography group, and none in the no-test + pickup group.Conclusions and RelevanceThis prospective, observational study found that medication abortion obtained following no-test telehealth screening and mailing of medications was associated with similar rates of complete abortion compared with in-person care with ultrasonography and met prespecified criteria for noninferiority, with a low prevalence of adverse events.