bluuebunny/crossref_metadata_2025_split huggingface dataset:
White center retinal hemorrhages revealing acute lymphoblastic leukemia
Authors: BENLAHBIB M , BENCHERIFA F , HAJJI Z , BOULANOUAR A , BERRAHO A 
Published: August 2014

AbstractPurpose Acute lymphoblastic leukemia is a severe affection related to invasion of the bone marrow by immature haematopoietic cells of the lymphoid lineage. Retinal hemorrhages with white center are secondary to a specific pathophysiological mechanism. They are exceptional when revealed acute leukemia.Methods Through clinical observation of a case of acute lymphocytic leukemia revealed by retinal hemorrhages with white center, we recall the pathophysiological mechanisms and clinical aspects of this rare retinal disease.Results A 16 years old child consult for myodesopsia in his left eye. The ophtalmological examination show a correct visual acuity 10/10 P2 in the right eye and 9/10 P2 in the left. We note a discolored conjunctiva with vascular occlusions. The examination of the fundus of eyes reveal a diffuse retinal hemorrhages with white center. The blood count analysis show ; 120.000/mm3 WBC, Hb 3.5 g / dl and platelet 37.000/mm3. The diagnosis of acute lymphoblastic leukemia is made. The child is cared for in a pediatric oncology service. He received a blood transfusion and chemotherapy with complete remission at the last control.Conclusion Ophthalmologic examination has a major interest in the diagnostic and therapeutic management of this disease.
Caruncular naevi investigated by in vivo confocal microscopy: reporting the first 5 cases
Authors: JULIENNE R , GRIVET D , CINOTTI E , PERROT JL , LABEILLE B , CAMBAZARD F , FOREST F , DUMOLLARD JM , PEOC'H M , GAIN P , THURET G 
Published: August 2014

AbstractPurpose During body screening of melanocytic lesions, naevi of the eyelids, conjunctiva and caruncula, although accessible to the dermatologist, are often missed out. These tumors have similar characteristics and prognosis as oral or genital ones. We report the first cases of caruncular naevi observed by in vivo confocal microscopy (IVCM).Methods Five patients, 4 men and 1 woman, who presented with a caruncular melanocytic lesion, were examined by IVCM, using the handheld dermatological IVCM Vivascope 3000 (Lucid Inc, NY, MAVIG GmbH, Germany) equipped with 830nm class IB laser.Results Mean age was 39 years old (25‐71). The tumors which were 2.2mm width on average (0.5 ‐ 3.0 mm) were present since 4 years on average (1‐10). Two patients had family history of skin melanoma. IVCM showed hyperreflective round cells that were either isolated or grouped within the lamina propria. No abnormal cells were observed. Despite the benign IVCM aspect, a surgical excision biopsy was performed on 4 patients, for definitive histopathology or esthetic reasons. All 4 were compound naevus on histopathology. The remaining patient had no progression at 6 months follow upConclusion The caruncular site is inaccessible to both dermatoscopic imaging and standard dedicated ophthalmological IVCM. The Vivascope 3000 overpass this site limitation thanks to the small head of the camera and its handy and portable dimensions. In all cases, the IVCM imaging correlated with histopathology. This is the first reported series of caruncular melanocytic lesions explored in IVCM. Grant: GIRCI Rhone Alpes Auvergne 2012
Follow‐up of patients under therapy with hydroxichloroquine via merg, sd‐oct, af and automated perimetry
Authors: MOGAVERO V , RUBERTO G , RAIMONDI M , LANTERI S , PICCININI P , BIANCHI PE 
Published: August 2014

AbstractPurpose To analyze alterations in patients in therapy with hydroxychloroquine via multiple functional tests.Methods We examined 55 patients (mean age 56.1±1.9) in long term therapy (93.8±95.6 months) with hydroxichloroquine. The patients were divided into 4 patological groups (RA,LES,connectivitis and others) and assuming therapy from less than 5 years (47 eyes), 5 to 10 (28 eyes) and more than 10 (36 eyes). They had a complete ophthalmologic visit, including logMAR visual acuity, multifocal ERG(61 hexagons program), frequency doubling technology, automated perimetry program 10‐2, spectral domain optical coherence tomography and autofluorescence at time 0 and at after 1 year. For the statistical analysis we considered the latencies and amplitudes of the 5 mfERG rings, the mean and pattern deviation (MD, PSD) results of the FDT and SD‐OCT.Results The patients were treated for 78 months in median and the median total dose was 115 gr. We found a reduction of the mfERG rings statistically significant (N1nV1, P1nV1, P1nVdeg1, N1nV2, P1nV2, P1nVdeg2, P1nV3, P1nVdeg3, P1nV4, P1nVdeg4, P1nV5, P1nVdeg5) while PSD and the MD did't show a loss of sensitivity in the follow up. We found a statistically significant thicker in 4 sector of retina(foveal, superior, nasal and periferical inferior)with SD‐OCT. The AF was positive in 9 eyes and negative in 58 eyes and did not change at the follow up.Conclusion In our study mfERG has been the first exam to show early damage in absence of manifest retinal changes. The meaning of thickening at SD‐OCT remains uncertain. Our aim now is to estabilish the eventual relationship between the thickened areas in SD‐OCT and the mfERG reduction lasting the follow up.
Treatment satisfaction: Can we trust our glaucoma patients?
Authors: TISSIER P , LEMIJ H , BAUDOUIN C 
Published: August 2014

AbstractPurpose To determine the characteristics and satisfaction regarding tolerance of glaucoma patients currently treated by prostaglandin analogues, in general ophthalmological consultations.Methods Multi‐centre, European and epidemiological survey among glaucoma patients receiving prostaglandin analogues. In a two page questionnaire, the participating ophthalmologists recorded: glaucoma history, previous treatments and reasons for change, tolerability and patient satisfaction, ocular surface disease (OSD) prevalence and other ocular signs.Results The data from the first country, The Netherlands, (164 patients) were analyzed. At the time of the study, 94% of patients were treated for glaucoma with preserved products. Of all patients, 89% declared to be satisfied or very satisfied. The mean score of tolerability evaluated on VAS (Visual Analog Scale) was 76.4 ± 17.5 mm. Signs of OSD were evident in 44% of patients. Of all patients, 32% reported symptoms upon instillation and 47% between instillations. Conjunctival Hyperemia was present in 47% of patients. The prevalences of both blepharitis/Meibomian gland dysfunction and dry eye were more than twice as high compared to the time of onset of therapy, with a change from 8 to 19% of patients for blepharitis and 14% to 33% for dry eye. Artificial tears were used in 38% of patients. Patient dissatisfaction was significantly associated with the presence of OSD, hyperaemia, ocular signs, symptoms upon and between instillation and the use of artificial tears.Conclusion These first results highlight the disconnection between the patients’ reported satisfaction and their ocular signs and symptoms. Ocular surface dysfunction needs to be investigated thoroughly in those who use preserved prostaglandin analogues.
Commercial interest
The effect of preservative free tafluprost on intraocular pressure in patients with ocular hypertension or primary open angle glaucoma
Authors: HOMMER A , KROMUS M , SCHMIDL D , GARHOFER G , SCHMETTERER L 
Published: August 2014

AbstractPurpose Since increased intraocular pressure (IOP) is the most important modifiable risk factor for the development and progression of glaucoma, potent and save IOP lowering therapy is of special importance. Preservative free prostaglandins offer a new treatment option using a potent topical drug without the disadvantages of a co‐administered preservatives. The aim of the present study was to investigate the effect of 8 weeks treatment with preservative free tafluprost on IOP in patients with glaucoma or ocular hypertension.Methods 16 patients with either primary open angle glaucoma with an uncontrolled intraocular pressure ≥ 30mmHg or patients with ocular hypertension with an IOP ≥ 30mmHg were included in the present open pilot study. For patients who were already on antiglaucoma therapy, a washout period with a duration of 4 weeks was scheduled. IOP was measured at 8am and 6pm after the washout period as well as 4 and 8 weeks of after start of topical drug treatment.Results A total of 16 patients (age range 31‐76 years) were included in the study. After the 4 week washout period, mean IOP was 35.6±4.5mmHg at the morning and 32.9±5.4mmHg at the evening measurement. 4 weeks after treatment start, a decrease in IOP by ‐31%±12% to 24.4±4.6mmHg (p<0.01) was observed at the morning measurement and by ‐34%±14% to 21.6±4.6mmHg (p<0.01) at the evening measurement. 8 weeks after treatment start IOP remained low, on average 24.4±4.6mmHg (‐31%±13% compared to baseline, p<0.01) in the morning and 21.9±3.9mmHg (‐32%±16% compared to baseline, p<0.01) in the evening.Conclusion The present data indicate that treatment with preservative free saflutan is safe and has the capacity to significantly decrease IOP in patients with primary open angle glaucoma and ocular hypertension. Further studies are needed to investigate the effect of preservative free formulations for long term treatment.
Test‐retest reliability on measuring anterior chamber parameters with a novel automatic algorithm using anterior segment optical coherence tomography
Authors: ANG L , LEE T , NG J , YIP L 
Published: August 2014

AbstractPurpose To describe the test‐retest variability in anterior chamber and iris parameters obtained on anterior segment optical coherence tomography (AS‐OCT) when measured with a novel automatic Location‐Based Graph Search segmentation algorithm.Methods Patients with open angles and primary angle closure on gonioscopic finding were invited for anterior chamber (AC) angle imaging with the Visante AS‐OCT. 3 scans of each eye were acquired in darkness with the patients repositioning their heads after each scan. The images were analysed with a custom software which used the iris rim as the landmark instead of the sclera spur. The parameters analyzed included angle opening distance and angle recess area at 750μm from the angle (AOD750 & ARA750), AC depth and width, lens vault, iris curvature, thickness, length and angle recess area. The test‐retest intrasession variability, coefficient of variation (COV) and intraclass correlation coefficient (ICC) were calculated to evaluate repeatability and reproducibility.Results 17 eyes with closed angles and 15 eyes with open angles were recruited. The ICC was >0.75 for most parameters of eyes with open angles and COV was <15%. For narrow angled eyes, the ICC was >0.75 for AC depth and width, lens vault, iris length and area, left AOD750 and ARA750 and angle recess, and <0.75 for other parameters. The COV for AC depth and width, iris length and area was <10% and >10% for other parameters.Conclusion There is test‐retest variability in AC parameters measured with the Visante AS‐OCT. The variability is greater in eyes with narrow angles but reliable in eyes with open angles. Caution must be exercised when using the AS‐OCT to follow up patients with narrow angles.
Hemifield patter electroretinogram and macular thickness asymmetry parameters in ocular hypertension patients
Authors: FINZI A , TASSI F , GIZZI C , CELLINI M 
Published: August 2014

AbstractPurpose To assess which is the most sensitive and specific exam for detecting an early retinal ganglion cells (RGC) damage between hemifield test pattern electroretinogram (PERG HF) and the posterior pole asymmetry analysis with optical coherence tomography (OCT‐PPAA) in ocular hypertensive patients (OH).Methods Forty‐two OH patients (mean age of 56.0±5.6 yrs.) with an intraocular pressure (IOP)>21mmHg and forty healthy controls (mean age of 55.2±6.4 yrs.) with IOP<21mmHg were assessed. All patients had normal visual acuity, normal optic disc appearance and normal standard achromatic perimetric (SAP) indices. All subjects underwent an OCT‐PPAA with the OCT‐Spectralis and PERG HF examination. Data were analyzed with Wilcoxon test and Receiver Operating Characteristic (ROC) curve analysis taking p < 0.05 as significant.Results We found that OH patients compared to healthy controls with full field PERG had a not significant decrease of the N95 wave amplitude (p<0.097) with a significant increase of its peak‐time (103.88 ± 11.11 vs 92.78 ± 4.30 msec; p<0.027). With PERG HF we found a significant intraeye asymmetry of the N95 wave (‐1.99±1.58 vs ‐0.67± 0.35 µVolt; p<0.023). With OCT‐PPAA in OH patients we found a decrease in macular thickness but not a statistical significant intraeye hemispheric asymmetry (3.94± 2.89 vs 5.98±4.74 µ; p<0.116). ROC curve analysis revealed a sensitivity of 80% and specificity of 87.6% for PERG HF whereas by using OCT‐PPAA we found a sensitivity of 70% and a specificity of 74%.Conclusion Our study shows that at the moment the PERG HF is the most sensitive and specific technique than OCT‐PPAA for detecting early RGC damages in eyes with ocular hypertension.
HRT versus OCT in diagnosing preperimetric glaucoma
Authors: BOUHACINA BENMANSOUR A , ROULAND J 
Published: August 2014

AbstractPurpose To compare the final classification of Glaucoma Probability Score (GPS) and analyze RNFL of OCT and to evaluate their capacities to detect precociously the glaucomatous defectsMethods Retrospective study, led in the regional center of glaucoma, in CHUR of Lille, including 122 eyes of 71 patients All the eyes included had, to the maximum, a light visual field defects and having profited all of them of a complete ophthalmic examination including vision, measurement of the PIO, standard automated perimetry, optic nerve head analysis was performed by using a confocal scanning laser ophthalmoscopy type Heidelberg retinal tomography (HRT III) and retinal nerve fiber layer (RNFL) by Optical Coherence Tomography (Cirrus OCT) The patients were divided into 3 groups according to the defect of the visual field: ‐ Group 1 : normal visual field ‐ Group 2 : MD between [0, ‐2] decibels ‐ Group 3 : MD between [‐ 2.1, ‐6] decibels The results of analysis RNFL on OCT and analysis GPS on the HRT were compared in each group.Results The discordance is important in group 2. The sensitivity of the two apparatuses increases with the depth of the defect but remains higher with the HRT.Conclusion There is not a difference between the two analyzers from ‐ 2,1 Decibels The GPS appears to be an algorithm more sensitive than analysis RNFL on OCT in detecting preperimetric glaucoma.
Evaluation of CANON SD HS 100 OCT : Reproducibility of macular ganglion cell complex (GCC) thickness measurement in normal, hypertensive and glaucomatous eyes
Authors: ROSENBERG R , MARILL AF , FENOLLAND JR , EL CHEHAB H , DELBARRE M , MARECHAL M , MOUINGA A , RENARD JP 
Published: August 2014

AbstractPurpose To evaluate intra‐ and interobserver reproducibility of macular GCC thickness measurement by automated segmentation on CANON SD HS 100 OCT (Japan) in normal (N), hypertensive (OHT) and glaucomatous eyes.Methods A total of 179 eyes of 93 patients were included: 88 N, 26 OHT and 65 glaucoma. All patients underwent a complete ophthalmologic exam, pachymetry and 24‐2 automated perimetry (HFA SITA Standard). Each of two observers performed three times macular imaging with SD HS 100 OCT. Acquisitions were analyzed with Glaucoma 3D mode which estimated the macular GCC thickness in global, upper and lower macular parts and in eight separate areas. Reproducibility was assessed by intraclasss correlation coefficient (ICC), coefficient of variation (CV) and test‐retest variability (TRTV) calculated as 1.96 times the standard deviation.Results Mean GCC thickness was respectively 92.6µm, 88.7µm, 77.4µm in N, OHT and glaucomatous eyes. In all groups, intra‐ and interobserver reproducibility was respectively ranged for ICC from 96 to 99.7% and from 84.5 to 99.7%, for CV from 0.44 to 2% and from 0.37 to 1.1% and for TRTV from 0.75 to 2.62 µm and from 0.59 to 1.47µm. Reproducibility is significantly better in N and OHT group than in glaucoma group (p<0.001).Conclusion Reproducibility of GCC thickness measurements using the new OCT SD HS 100 is high. These results might be related to a high axial resolution (3µm). They underline reliability data for analyze of GCC.
Visual field defects in pre‐perimetric glaucoma identified by customized oct ‐ guided white‐on‐white automated perimetry
Authors: MAGOURITSAS G , GEORGIADIS O , PORTALIOU DM , MOSCHONAS K 
Published: August 2014

AbstractPurpose We studied cases of “preperimetric” glaucoma using detailed strategies of the AP in order to detect any functional disturbance in visual field areas corresponding to the localized structural damage.Methods We enrolled 5 patients with inter‐ocular optic disc cupping asymmetry, ocular hypertension asymmetry, optic disc hemorrhage and retinal nerve fiber layer (RNFL) outside normal limits, as measured by means of optical coherence tomography (OCT). All of the 5 patients fulfilled the diagnostic criteria for “preperimetric” glaucoma, showing a normal standard visual field analysis. They were submitted in a more specific white‐on‐white AP using customized programs with a 3 degrees grid, instead of the standard 6 degrees used in routine 24‐2 and 30‐2 programs of the Humphrey AP. The examination of the visual field test points in a customized pattern has been guided by the corresponding abnormal region of the OCT, according to the structure‐function map proposed by Garway‐Heath et al (Ophthalmology. 2000;107:1809)Results Using the denser grid of 3 degrees spot, we detected reduced threshold sensitivity in 3 study eyes, in specific areas of the visual fields. The topography of these areas corresponded to the morphology of the localized RNFL lesion. In 2 eyes the 3 degrees customized, OCT guided, AP could not identify any functional disturbance.Conclusion Early defects of visual fields may coexist with morphological damage of optic nerve and RNFL, even in “preperimetric” glaucoma, but remain undetected by the currently available routine 6 degrees grid programs of AP. Customized OCT guided AP may establish the diagnosis of glaucoma and put controversy in the term of “preperimetric” glaucoma.
Interest of central 10‐2 visual field in glaucomatous and glaucoma suspects patients with normal central 24‐2 visual field
Authors: MARECHAL M , CHAPRON T , EL CHEHAB H , FENOLLAND JR , MARILL AF , ROSENBERG R , DELBARRE M , MOUINGA A , RENARD JP 
Published: August 2014

AbstractPurpose To evaluate benefit of performing central 10‐2 visual field (VF) in association with 24‐2 VF in glaucomatous or glaucoma suspect patients.Methods 20 glaucoma suspect (Mean Deviation MD=0.19±0.8dB) and 48 glaucomatous eyes (MD=‐2.33±1.9dB) with normal central 24‐2 VF were included. Patients without macular pathology underwent a complete ophthalmological examination and a reproducible VF testing (Humphrey Field Analyser, SITA standard 24‐2 and 10‐2, Carl Zeiss Meditec) and analyze of ganglion cell inner plexiform layer and of retinal fiber layer thickness by Cirrus HD‐OCT.Results Central 10‐2 VF detect a central defect in 15 eyes (22%). In glaucoma suspect group, a defect was detected by 10‐2 VF whereas 24‐2 VF was normal for 2 patients (10%). In glaucomatous group a central 10‐2 VF defect missed by 24‐2 VF was detected in 7 patients (15%). An extended central 10‐2 VF defect associated with a suspect or a small paracentral 24‐2 VF defect was reported for 6 glaucomatous patients (13%).Conclusion Central VF defect may be missed by 24‐2 VF analyze. Central 10‐2 VF seems to be useful in glaucoma suspect and in glaucomatous eyes for a better detection of early central functional defect.
Comparison of two methods for location of the ciliary body before glaucoma treatment using High Intensity Focused Ultrasound (HIFU)
Authors: APTEL F , ROULAND J , CHAVEROT D , DUPUY C , COPPIN J 
Published: August 2014

AbstractPurpose To evaluate the ability of the white‐to‐white (WTW) and axial length (AL) measurements to determine the location of the ciliary body before High Intensity Focused Ultrasound (HIFU) glaucoma treatment.Methods 189 eyes (104 phakic, 85 pseudophakic) of 161 patients were included. WTW and AL measurements were measured with the IOLMaster. The HIFU size probe selection was done based using ultrasound biomicroscopy (UBM) and a computer assisted overlay drawing method performed by the manufacturer of the HIFU device. Three probe models with different ring diameters (11, 12 and 13mm) are available for HIFU treatment. Eyes were divided into 3 groups: “11” (n=11), “12” (n=83) and “13” (n=95) corresponding to the size of the probe recommended based on UBM images. The agreement between the group and the WTW and AL were evaluated.Results For groups "11", “12” and “13”, mean WTW and AL measurements were respectively 11.44 ± 0.11 mm and 22.04 ± 0.28 mm, 11.84 ± 0.04 mm and 23.22 ± 0.20 mm, and 12.36 ± 0.06 mm and 25.43 ± 0.3 mm. Mann&Whitney and ANOVA tests showed a significant difference between the 3 groups (p<.05). By placing all the data in a coordinate system WTW‐AL, we can distinguish 3 areas (11, 12 and 13) allowing to choose the diameter with a 93% agreement with the UBM‐based determination.Conclusion It seems possible to determine the probe model with a nomogram based on easily measurable ocular parameters.
Multicenter clinical trial of ultrasonic circular cyclo coagulation in glaucoma patients naive of filtering surgery. Preliminary results at 6 months
Authors: APTEL F , DENIS P , ROULAND J , RENARD JP , BRON AM 
Published: August 2014

AbstractPurpose To evaluate the efficacy and safety of the Ultrasonic Circular Cyclo Coagulation (UC3) procedure in patients naive of previous filtering glaucoma surgery.Methods Prospective non comparative interventional clinical study performed in 5 French glaucoma centers. Thirty eyes of 30 patients (24 primary open‐angle glaucoma and 6 secondary glaucoma), with intraocular pressure (IOP) > 21 mmHg, naïve of previous filtering glaucoma surgeries, were insonified with a therapy probe comprising 6 piezoelectric transducers. The 6 transducers were activated with a 6 seconds exposure time. Complete ophthalmic examinations were performed before the procedure, and at 1 day, 1 week, 1, 2, 3, 6 and 12 months after. Primary outcomes were surgical success (defined as IOP reduction from baseline ≥ 20% and IOP > 5mmHg) at the last follow‐up visit, and vision‐threatening complications. Secondary outcomes were mean IOP at each follow‐up visits compared to baseline, medication use, and complications.Results IOP was significantly reduced (p<0.05), from a mean preoperative value of 28.3 ± 7.0 mmHg to a mean value of 19.5 ± 7.2 mmHg at 6 months. Success (IOP reduction >20%) was achieved in 63% of eyes at 6 months after one HIFU procedure, with a mean IOP decrease of 39%. No major intra‐ or post‐operative complications occurred.Conclusion Ultrasonic Circular Cyclo Coagulation seems to be an effective and well tolerated method to reduce intraocular pressure in glaucoma patients naïve of previous glaucoma surgery.
Commercial interest