bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisa Kejadian Anemia Defisiensi Besi Pada Anak Usia Dini Berdasarkan Formula Indeks Mentzer
Authors: Jamaluddin Thaslifa , Alfyan Rahim  , Eka Haryanti  
Published: August 2024

Anemia lebih dikenal oleh masyarakat sebagai penyakit kurang darah. Secara global, penderita anemia mencapai 2,3 miliar. Asia dan Afrika tercatat memiliki prevalensi kejadian anemia tertinggi yaitu 85% yang dialami oleh wanita dan anak-anak. Sekitar 50% diantaranya mengalami anemia defisiensi besi (ADB). Anak usia dini masih sangat membutuhkan pemenuhan akan gizi seimbang seperti karbohidrat, protein, lemak, mineral dan vitamin termasuk zat besi (Fe). Fe berperan dalam proses pembentukan eritrosit, sintesa hemoglobin, dan suplai oksigen ke seluruh jaringan. Kekurangan Fe dapat menyebabkan Anemia Defisiensi Besi (ADB). Penelitian ini bertujuan untuk mengetahui kejadian anemia pada anak usia dini (5-12 tahun) berdasarkan formula indeks Mentzer. Penelitian bersifat desktiptif dengan pendekatan cross-sectional study yang dilakukan di RSIA Sitti Khadijah Makassar berdasarkan data sekunder (rekam medis) selama dua tahun. Besar sampel yang digunakan yaitu 80 data yang diperoleh melalui tehnik purposive sampling. Berdasarkan perhitungan formula indeks Mentzer diperoleh hasil penelitian sekitar 85% orang anak yang mengalami anemia defisiensi besi (ADB), Thalassemia sebanyak 8,75% orang anak, dan normal sebanyak 6,25%. Penyakit ADB pada anak usia dini perlu penanganan yang cepat dengan melihat faktor-faktor risiko yang dapat mempengaruhi kejadian ADB.
Implementasi Penggunaan Sistem Informasi Manajemen Rumah Sakit di Rumah Sakit Dr.Sumantri Dalam Peningkatan Pelayanan Kesehatan
Authors: Rustan Fajriana 
Published: August 2024

Sistem Informasi Manajemen Rumah Sakit merupakan suatu sistem komputerisasi yang mampu melakukan pengolahan data secara cepat dan akurat. Sistem Informasi Manajemen Rumah Sakit merupakan suatu sistem komputerisasi yang mampu melakukan pengolahan data secara cepat dan akurat. Namun penggunaan SIMRS belum menyeluruh hanya terhubung pada unit loket pendaftaran, kasir/billing dan apotik/farmasi. Adapun kendala yang didapat selama pengimplementasiannya yaitu masalah terkait jaringan dan sumber daya manusianya. Tujuan penelitian ini untuk mengetahui “Implementasi Penggunaan Sistem Informasi Manajemen Rumah Sakit di Rumah Sakit Dr. Sumantri”. Jenis penelitian ini adalah kualitatif dengan metode deskriptif analisis, dimana teknik pengambilan informan dilakukan dengan teknik purposive sampling yang meliputi pihak manajemen, petugas di unit loket pendaftaran, petugas unit kasir/billing, petugas unit apotik/farmasi dan pasien. Hasil penelitian menunjukkan bahwa implementasi penggunaan Sistem Informasi Manajemen Rumah Sakit sudah berjalan dengan baik hanya saja belum secara keseluruhan dikarenakan masih terkoneksi ditiga unit bagian saja. Diharapkan penggunaan Sistem Informasi Manajemen Rumah Sakit lebih menyeluruh agar lebih meningkatkan pelayanan kesehatan.
UJARAN KEBENCIAN PADA KOMENTAR TIKTOK @OFFICIALRCTI TERHADAP MARISA PESERTA X FACTOR INDONESIA
Authors: Nur Azizah  , Dhella Patrichia Chandra  , Ian Wahyuni  
Published: August 2024

This research aims to analyze and find out hate speech that leads to insulting one of the contestants at the X Factor Indonesia 2024 event by focusing on the comments column on the TikTok account @officialrcti. This type of research is descriptive qualitative research by connecting the theories of Pragmatics and Forensic Linguistics. The data used in this research is in the form of netizen comments on the tiktok account @officialRcti. This research will identify hate speech uttered by netizens in the comments column regarding Marisa's appearance as a contestant

on X Factor Indonesia 2024 by understanding the context of pragmatic theory, followed by analysis based on the type of marginalization of hate speech and linking it to the theory of Forensic Linguistics contained in article 156 paragraph 1 of the Criminal Code and UU article 28 paragraph 2 of the ITE Law. The results of this research are to provide knowledge about hate speech in language or insight into understanding Forensic Linguistics.
DEVELOPMENT OF SUNDANESE GAMELAN ETHNOMATHEMATICS E-MODULE FOR JUNIOR HIGH SCHOOL MATHEMATICS LEARNING
Authors: Supriyadi Edi , Turmudi T. , Afgani Dahlan Jarnawi , Juandi Dadang 
Published: August 2024

Purpose – This study aimed to conduct a needs analysis for developing the ethnomathematics e-module based on Sundanese Gamelan to facilitate mathematics learning in junior high school. Specifically, this study identified crucial components for module development and to gather feedback from both students and teachers regarding the learning material.
Methodology – The Research and Development (R&D) method was used, specifically the Plomp model, to create e-module for mathematics learning. Qualitative data were collected from ethnomathematics experts, a mathematics teacher, and five students via purposive sampling. The instruments used for this data collection included expert validation sheets, student interview recordings, teacher questionnaires, and small group observations.
Findings – The results indicated that the integration of Sundanese Gamelan ethnomathematics into junior high school mathematics e-module significantly improved students’ understanding and interest in the subject. This culturally infused approach increased students’ motivation and engagement, indicating a potential shift towards more inclusive and culturally responsive educational practices.
Significance – The integration of Sundanese Gamelan ethnomathematics into mathematics curriculum is known for the unique blend of cultural elements with academic content, contributing to enhanced students’ understanding and cultural awareness. In addition, this method offered benefits for students, teachers, curriculum developers, and ethnomathematics researchers, presenting a holistic model that combined educational innovation with cultural appreciation.
EFL LEARNERS’ MOTIVATIONAL BEHAVIOR: A COMPARISON ACROSS TEN GRADE LEVELS
Authors: Cheng Yuh-Show 
Published: August 2024

Purpose – Given the research gaps identified in a literature review, this study aims to uncover how the intensity of learners’ motivational behavior and its predictors vary with grade level.
Methodology – A large-scale survey was conducted to examine motivational behavior and its predictors among EFL learners across three education levels and ten grades in Taiwan: primary school (Grades 3 to 6), junior high school (Grades 7 to 9), and senior high school (Grades 10 to 12). A total of 12,441 valid cases were collected from both rural and urban areas in Taiwan. ANOVA and multiple regression analysis were used to analyze the data.
Findings – The results showed a significant effect of grade level on the intensity of motivational behavior. Specifically, learners’ intensity of motivational behavior tended to decline with grade level (years of study). The significant predictors of motivational behavior also differed with grade level.
Significance – In addition to theoretical and methodological contributions to L2 motivation research, this study can enhance understanding of factors that could enhance learners’ motivational behavior and offer implications to assist EFL teachers in developing motivational teaching strategies.
WACANA GRAFITI PADA ANGKUTAN UMUM DI KABUPATEN TIMOR TENGAH UTARA
Authors: Lawak Veronika , Dapubeang Abdul Rahim Arman Putera , Pinka Rafli Ubit 
Published: August 2024

Penelitian ini memiliki dua tujuan, yaitu untuk mendeskripsikan bentuk wacana grafiti pada angkutan umum di Kabupaten Timor Tengah Utara, untuk mendeskripsikan makna wacana grafiti pada angkutan umum di Kabupaten Timor Tengah Utara. Jenis penelitian ini adalah deskriptif kualitatif. Subjek penelitian adalah angkutan umum di Kabupaten Timor Tengah Utara khususnya di kota Kefamenanu. Teknik pengumpulan data dilakukan melalui teknik observasi dan dokumentasi. Teknik analisis data dilakukan secara deskriptif kualitatif dengan menggunakan model Van Dijk. Hasil penelitian menunjukkan bahwa bentuk wacana grafiti pada angkutan umum diklasifikasikan berdasarkan (1) Deskripsi struktur makro (tematik/alur) wacana grafiti: grafiti sosial, grafiti ekonomi, grafiti romantis, dan grafiti religi. (2) Deskripsi superstruktur (skema) wacana grafiti deskripsi struktur mikro (tematik/alur) wacana grafiti. (3) deskripsi struktur mikro wacana grafiti: a) Semantik: latar, detail, maksud, dan praangkapan. b) Sintaksis: bentuk kalimat, koherensi (koherensi sebab-akibat), pengingkaran. c) Leksikon, d) Retoris, (grafis dan metafora) (4) deskripsi konteks wacana grafiti a. S: latar, P: peserta tuturan, E: tujuan, A: pesan atau amanat K: kunci, I: sarana, N: norma, G: jenis.
Translating Iraq’s selected Covid-19 Cartoons into English
Authors: Al-Taie Ruqaya 
Published: August 2024

Cartoons, since they combine written text and visual content, has a major role in conveying different messages about Covid-19. This significance has typically come from the power of images and words that occurred in the cartoons and their impact on receivers’ response thereafter. In translation, cartoon creates difficulty because of the cultural aspects and ideas that are created for a specific audience and community. Hence, in this paper, the focus will be specifically on analysing the language of selected cartoons and the translation approaches of the cartoonists’ language in the Covid-19 era in Iraq, and this analysis is attained by adopting Norman Fairclough’s model of critical discourse analysis. The researcher has categorised cartoons as follows: rhetorical, idiomatic, narrative, and rhymed, so this paper will concentrate on the analysis of the message behind each category that is employed to influence the audience and how it can be translated, especially if it encompasses idioms related to the Iraqi culture, musical rhyme, rhetoric, and pun. Accordingly, analysis of the constituent aspects of the cartoons necessarily takes place on linguistic and cultural levels so as to distinguish how each cartoonist represents the denotative and connotative meanings of the lexical items that are associated with cartoons drawings.
Performing a physiologically relevant test for cladribine tablets
Authors: Losenkova P. A. , Gvozdev D. D. , Suvorova A. V. , Medvedev Yu. V. , Shcherbakova V. S. , Kazaishvili Yu. G. , Zaslavskaya K. Ya. , Poluyanov A. M. , Shohin I. E. 
Published: August 2024

Introduction. The introduction of devices – analogues of GIS (hereinafter–- Gastro-intestinal simulator) is one of the current ways to develop in-vitro assessment of the quality of solid dosage forms. Testing on a physiologically relevant test device (hereinafter referred to as PRT) makes it possible to predict pharmacokinetic profiles due to more relevant conditions, including the use of biorelevant dissolution media, physiological volumes of the gastrointestinal tract, as well as transit between them.Aim. Conduct a study of cladribine tablets on a physiologically relevant tester in order to predict the behavior of the drug in the human gastrointestinal tract.Materials and methods. The objects of the study are "Mavenclad®, tablets, 10 mg" (series 2200754, expiration date until 04.2025, NERPHARMA, S.r.L., Italy) and "Cladribine, tablets, 10 mg" of domestic production with valid expiration date. During the study, the reagents necessary for the preparation of biorelevant dissolution media and quantitative determination by HPLC. Physiologically relevant test were carried out using an apparatus of our own production, consisting of a DT-6 dissolution tester (ERWEKA GmbH, Germany), a water bath equipped with a Thermomix WB-4 heating element (B. Braun, Germany), and peristaltic pumps (Kamoer, China). The quantitative content of released cladribine was assessed using a highly efficient liquid chromatograph "Khromatek-Kristall HPLC 2014" (ZAO SKB "Khromatek", Russia) using a validated method at a wavelength of 252 nm, analysis time – 7 min, column – Grace HPLC Column Platinum C18-EPS, 250 × 4.6 mm, 5 mm (Grace, USA), temperature – 35 °C, elution mode – isocratic (A : B 80 : 20), mobile phase A – 0.1 % H3PO4 solution, phase B – acetonitrile.Results and discussion. Profiles were obtained to assess the dynamics and degree of release of the studied drugs in various parts of the human gastrointestinal tract. Despite the expected degradation of cladribine in an acidic environment (pH1.2), under physiologically relevant conditions, the drug reached the third section (small intestine model) without degradation. Complete release of cladribine from the test and reference dosage forms was observed. Also, in the future, based on the data obtained, it is possible to predict pharmacokinetic profiles using physiologically based pharmacokinetic modeling approaches.Conclusion. A PSF study was conducted for the drugs "Mavenclad®, tablets, 10 mg" and "Cladribine, tablets, 10 mg". Quantitative determination was carried out by HPLC-UV method. The test results showed complete release of both drugs and reaching the intestinal tract, indicating the absence of degradation of cladribine in the region simulating the stomach.
Influence of landscape on the presence of Batrachochytrium dendrobatidis and Ranavirus in tadpoles in the southern Atlantic Forest of Brazil
Authors: Santos Roseli Coelho dos , Dalmolin Diego Anderson , Ruggeri Joice , Brum Diego , Veronez Mauricio Roberto , Lucas Elaine Maria , Tozetti Alexandro Marques 
Published: August 2024

IntroductionHabitat loss, as well as infectious diseases, have been suggested as the main causes for the worldwide decline of amphibian populations. Thus, the search for biotic indicators is a useful tool for mapping priority demands in disease management.AimsHere we analyzed the prevalence of two pathogens, Batrachochytrium dendrobatidis (Bd) and Ranavirus (Rv), in anuran communities in southern Brazil. We explored the relationship between the prevalence of Bd and landscape class and used an indicator-species and indicator-community approach to identify which species and communities have the potential to indicate the presence of Bd.MethodsWe used histological analyses to access Bd and PCR for Rv in tadpole communities.Key resultsOur data, based on 26 anuran communities, revealed high Bd prevalence but absence of Rv. Three species, of the 26 communities studied, were found to be Bd indicators, including endemic species from southern Brazil and Argentina. Additionally, the analysis with an indicator-community approach revealed that communities from larger forest areas are Bd indicators.ConclusionsAnalyses at the community level, which relate landscape to pathogens, provide unprecedented and highly relevant information for fragmented Atlantic Forest landscapes. Based on our results, we argue that even communities in larger forest patches (apparently well-preserved) are susceptible to Bd and deserve attention regarding the possibility of incidence of chytridiomycosis. Implications. From our results, we consider that the use of Bd-indicator species and Bd-indicator communities is a useful approach for conservation and could be used to evaluate the threatened status of species and for proposals for landscape management.
Comparison of two viscoelastic testing devices in a porcine model of surgery, hemorrhage and resuscitation
Authors: Gruneberg Daniel , Dietrich Maximilian , Studier-Fischer Alexander , Petersen Clara , von der Forst Maik , Özdemir Berkin , Schöchl Herbert , Nickel Felix , Weigand Markus A. , Schmitt Felix C. F. 
Published: August 2024

IntroductionViscoelastic hemostatic assays (VHA) are integral in contemporary hemostatic resuscitation, offering insights into clot formation, firmness, and lysis for rapid diagnosis and targeted therapy. Large animal models, particularly swine, provide anatomical and physiological analogies for coagulation research. Despite the growing use of VHAs, the ClotPro® device’s applicability in porcine models remains unexplored. This study investigates ClotPro® in a porcine model of abdominal surgery, severe hemorrhage, and resuscitation, comparing it with the established ROTEM® delta system.MethodsTwenty-seven healthy pigs underwent abdominal surgery, hemorrhage and resuscitation. ClotPro® and ROTEM® were used to assess viscoelastic hemostatic properties at baseline, after surgery, 60 min after shock induction, 60 and 120 min after resuscitation.ResultsClotting times in extrinsically and intrinsically stimulated assays exhibited fair to moderate correlation. Clot firmness in extrinsically stimulated tests could be used interchangeably while fibrin polymerization assays revealed significant differences between the devices. Fibrin polymerization assays in ClotPro® consistently yielded higher values than ROTEM®. Furthermore, the study evaluated the ClotPro® TPA-test’s applicability in porcine blood, revealing failure of lysis induction in porcine blood samples.ConclusionThis research contributes valuable insights into the use of ClotPro® in porcine models of hemorrhage and coagulopathy, highlighting both its applicability and limitations in comparison to ROTEM® delta. The observed differences, especially in fibrin polymerization assays, emphasize the importance of understanding device-specific characteristics when interpreting results. Due to its inapplicability, TPA-test should not be used in porcine blood to evaluate fibrinolytic potential. The study provides a foundation for future investigations into the use of different viscoelastic hemostatic assays in porcine animal models.
The diagnostic value of 68Ga-NOTA-MAL-Cys-MZHER2:342 PET/CT imaging for HER2-positive lung adenocarcinoma
Authors: Li Shu , Wang Ke , Zhu Xue , Pan Donghui , Wang Ling , Guo Xu , Gao Xiaomin , Luo Qing , Wang Xun 
Published: August 2024

BackgroundThe human epidermal growth factor receptor 2 gene (HER2) has been identified as a potential therapeutic target in lung adenocarcinoma (LUAD). Non-invasive positron emission tomography (PET) imaging provides a reliable strategy for in vivo determination of HER2 expression through whole-body detection of abnormalities. The PET tracer 68Ga-NOTA-MAL-Cys-MZHER2:342 has shown promising results for HER2-positive breast and gastric cancers. This study aims to evaluate the performance of 68Ga-NOTA-MAL-Cys-MZHER2:342in vitro and in vivo models and in clinical patients with HER2-positive LUAD.MethodsNOTA-MAL-Cys-MZHER2:342 was synthesized and labeled with 68Ga. Cell uptake, cell binding ability, and stability studies of 68Ga-NOTA-MAL-Cys-MZHER2:342 were assessed both in the Calu-3 lung cancer (LC) cell line and normal mice. In vivo assessment in tumor-bearing mice was conducted using microPET imaging and biodistribution experiments. Additionally, preliminary PET/CT imaging analysis was performed on HER2-positive LC patients.Results68Ga-NOTA-MAL-Cys-MZHER2:342 was prepared with a radiochemical purity (RCP) exceeding 95%. The tracer demonstrated high cell uptake in HER2-overexpressing Calu-3 cells, with an IC50 of 158.9, an adequate 1.73 nM. Good stability was exhibited both in vitro and in vivo. MicroPET imaging of Calu-3-bearing mice revealed high tumor uptake and notable tumor-to-background ratios. Positive outcomes were also observed in two HER2-positive LUAD patients.Conclusion68Ga-NOTA-MAL-Cys-MZHER2:342 demonstrated satisfactory stability, sensitivity, and specificity. These findings suggest that 68Ga-NOTA-MAL-Cys-MZHER2:342 PET/CT imaging provides a novel tool for non-invasive visual assessment of HER2 expression in LUAD patients.
Occlusal effects on text reading: an eye-tracker study
Authors: Tramonti Fantozzi Maria Paola , De Cicco Vincenzo , Bazzani Andrea , Cataldo Enrico , Bruschini Luca , De Cicco Davide , d’Ascanio Paola , Faraguna Ugo , Manzoni Diego 
Published: August 2024

IntroductionAsymmetric electromyographic (EMG) activity during teeth clenching has been linked to cognitive impairment, as evaluated by the Spinnler-Tognoni matrices test, and to asymmetric pupil size (anisocoria). Anisocoria indicates an asymmetric Locus Coeruleus activity, leading to an asymmetric hemispheric excitability worsening cognitive performance. Bite splint wearing corrects EMG asymmetry, reduces anisocoria and improves cognitive performance. This study explores the possible effect of EMG asymmetry on oculomotor behavior during text reading.MethodsIn subjects showing different degrees of EMG asymmetry during clenching, the number and duration of fixation periods during a reading task, performed under two different occlusal conditions were analyzed. The first lecture was executed with a dental impression (imprint) interposed between the dental arches (corrected condition) and the second one with the arches in direct contact (habitual condition), without clenching effort. The imprint reduced the EMG asymmetries during clenching.ResultsIn both occlusal conditions, total reading time correlated with duration of fixations, but not with their number. An inverse relation was observed between the number of fixations and their duration across individuals. Fixation frequency and duration were positively and negatively correlated with the amplitude of EMG asymmetry, respectively. Differently, total reading time was not related to the EMG asymmetry. When switching from the corrected to the habitual condition, an increase in the number of fixations and a reduction in their duration was observed, while total reading time could be either increased or decreased. An increased fixation frequency was observed in most of the subjects, while a reduced duration only among individuals with shorter reading times in habitual condition.DiscussionIn the habitual condition, EMG asymmetry influences reading patterns (more saccades/shorter fixations, less saccades/longer fixations) in our sample. The changes in text reading behavior elicited by occlusal correction can be explained by assuming that occlusal disharmony negatively interferes with the reading task by increasing the number of saccades necessary for text scanning. This finding may also indicate an increased difficulty in processing of visual information. The potential involvement of trigeminal pathways in the relation between occlusal factors and oculomotor control is discussed.