bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrocardiographic abnormalities are frequently detected in healthy adult Borzoi with a normal echocardiogram
Authors: Wesselowski Sonya , Janacek Blakeley , Sykes K. Tess , Saunders Ashley B. 
Published: July 2024

Abstract

OBJECTIVE
Borzoi reportedly experience sudden death. The objective of this study was to report ECG intervals, amplitudes, and frequency of ECG abnormalities in clinically healthy Borzoi.

METHODS
98 clinically healthy Borzoi were prospectively recruited and underwent echocardiogram, ECG, and cardiac troponin I testing between October 2020 and December 2022. Standard ECG measurements were obtained. Early repolarization notches and slurs were recorded.

RESULTS
Of 82 Borzoi with a structurally normal echocardiogram, ventricular arrhythmias were documented in 8 (10%) dogs, all of which had normal cardiac troponin I concentrations. Median P wave duration was 55 milliseconds (range, 45 to 70 milliseconds). Median PR interval was 125 milliseconds (range, 80 to 175 milliseconds). Thirty-one (38%) Borzoi had first-degree atrioventricular block (PR interval > 130 milliseconds). Median QRS duration was 65 milliseconds (range, 48 to 90 milliseconds). Median QT interval was 235 milliseconds (range, 185 to 275 milliseconds). Twenty-nine (35%) and 15 (18%) of 82 Borzoi had QT intervals > 240 or > 250 milliseconds, respectively. Sixty-seven of 82 (82%) Borzoi had early repolarization notches or slurs. Seventeen of 82 (21%) Borzoi had an abnormality of the ST segment, most commonly convexity/doming. Convexity of the ST segment was intermittent (n = 9) or persistent (4).

CONCLUSIONS
Ventricular arrhythmias, early repolarization, prolonged QT intervals, and ST segment abnormalities are not infrequent in clinically healthy Borzoi. P, PR, and QRS durations are commonly prolonged compared to general canine reference intervals.

CLINICAL RELEVANCE
Future study into heritable channelopathies in Borzoi is warranted given the frequency of ventricular arrhythmias, repolarization abnormalities, and sudden death in the breed. Breed-specific ECG reference intervals are needed.
Fınancıal sustaınabılıty and rısk in antı-agıng startups
Authors: Besirikli Mehmet Mustafa 
Published: July 2024

Abstract
The anti-aging industry has experienced rapid growth driven by significant advancements in biotechnology, consumer interest in longevity, and substantial investment. This study explores the financial sustainability and risk management practices of anti-aging startups, highlighting key challenges and opportunities. Through case studies, the research examines funding strategies, regulatory hurdles, and market dynamics. Successful startups demonstrate robust financial planning, strategic partnerships, and innovative technological approaches, while unsuccessful ventures reveal the high risks associated with clinical development. The findings underscore the importance of comprehensive risk management and strategic financial planning in achieving long-term sustainability. This research provides valuable insights for entrepreneurs, investors, and policymakers aiming to navigate the complex landscape of the anti-aging market.
Pengaruh Iklim Kerja dan Kompetensi terhadap Produktivitas Kerja Pegawai KPRI Sejahtera Kabupaten Brebes
Authors: Zakaria Alif Ilham , Subroto Setiowati 
Published: July 2024

Melihat dari latar belakang masalah dalam penelitian ini menjadi alasan peneliti bahwa pegawai KPRI Sejahtera Kabupaten Brebes memiliki tingkat absensi yang kurang baik dilihat dari data absensi pegawai yang disebabkan kurang nyamanya iklim kerja didalam organisasi yang membuat pegawai sering telat dan pulang dijam kantor. Organisasi harus mengembangkan kompetensi pegawai untuk menambah pengetahuan dan wawasan pegawai sehingga pegawai memiliki jiwa yang berkompeten dalam menjalankan tanggung jawabnya. Metode penelitian yang digunakan adalah wawancara dan penyebaran kuisoner. Jumlah sampel dalam penelitian ini adalah 32 responden. alat analisis yang digunakan adalah uji validitas, uji reliabilitas, uji asumsi klasik, uji regresi linear berganda dan uji signifikansi koe­fi­sien regresi liniear berganda. Hasil penelitian ini menunjukan 1). terdapat pengaruh yang positif dan tidak signifikan iklim kerja terhadap produktivitas kerja pegawai. Dari hasil uji t diperoleh t hitung variabel iklim kerja (X1) sebesar 4,319 sedangkan t tabel sebesar 1,659, maka diketahui t hitung > t tabel dengan niali sig 0,108 > 0,05. 2). terdapat pengaruh yang positif dan signifikan kompetensi terhadap produktivitas kerja pegawai. Dari hasil uji t diperoleh t hitung variabel kompetensi (X2) sebesar 4,319 sedangkan t tabel sebesar 2,045, maka diketahui t hitung > tabel dengan nilai sig 0,000 < 0,005. 3). Iklim kerja dan kompetensi terhadap produktivitas kerja secara bersama-sama (simultan) berpengaruh signifikan terhadap produktivitas kerja. Nilai F hitung yang diperoleh adalah 164,555 sedangkan F tabel sebesar 4,17. Maka diketahui nilai F hitung 164,555 > 4,17 dengan tingkat signifikan 0,000 < 0,05. Berdasarkan dari penelitian yang dilakukan pada penelitian ini dapat ditarik kesimpulan bahwa iklim kerja dan kompetensi berpengaruh secara positif dan signifikan terhadap produktivitas kerja pegawai KPRI Sejahtera Kabupaten Brebes.
Biogenic Fabrication of CuO Nanoparticles by <i>Oxalis corniculata</i> L. to Evaluate Antibacterial and Hypoglycemic Activity on Diabetic Mice
Authors: Bala Niranjan 
Published: July 2024

Plant-based synthesis techniques of nanoparticles are interested because of their cheap production cost, non-toxic nature and eco-friendliness. Metal oxide nanomaterials combined with plant metabolites have synergistic effects on antibacterial and antidiabetic potential. Biogenic fabricated nanoparticles of copper oxide has been accomplished with Oxalis corniculata L. leaf extract. For the characterization of nanomaterial XRD, UV-visible spectroscopy and FTIR Spectroscopy were used. The size and morphology of the NPs were measured using FESEM and HRTEM. The antibacterial potential of synthesized CuO NP has been studied upon Gram (+ve) Staphylococcus aureus and Gram (-ve) Escherichia coli bacteria. Ameliorative action of CuO NPs was tested against streptozotocin-induced diabetes in Swiss albino mice. Synthesized CuO NPs were well crystalline and 20-36 nm sized spherical particles. A strong peak at A298 using UV-Vis was verified the synthesis of CuO NP. Synthesized nanomaterial exhibits satisfactory antibacterial efficacy on both bacterial strains. Data from biochemical, inflammatory and non-inflammatory cytokine profiles of the mice justify its ameliorative action and mode of anti-diabetic activity on Swiss albino mice.
The documentary analysis in the curriculum development: A challenge for the teachers.
Authors: Sarmiento Pedro , Tovar María Clara 
Published: July 2024

Introduction: This study, realized during the year 2006 -2007, intends to analyze the coherence and relevancy of the univer-sity policies on the curriculum design, through the review of some documents that define the curriculum guidelines at university level, Faculty and every academic program levels in the Faculty of Health of the Universidad del Valle, related to the foundation phases and curriculum structure of the eight pregrade programs. Objectives: To analyze the coherence and documentary relevancy of the curricular policies in the University, the Faculty and the Academic Programs of the Faculty of Health of the Universidad del Valle. Material and methods: A documentary analysis was realized by applying coherence and relevancy criteria to the university selected institutional documents, the faculty’s and the programs’, produced in relation with the design task and curricular adjustment. Results: The coherence and relevancy of the documents in three levels has different developments: for some academic programs the relation is incipient, others do not show relations between coherence and relevancy and they seem to be two conceptual independent elements. Discussion and conclusions: The documents constitute an important data source for an investigator, articulating macro to micro, the institutional level with the level of the program and a conceptual support for the curricular design/adjustment. Nevertheless, the integral characterization of the design and the curricular adjustment comes out the documentary study and involves multiple processes and actors that imply other methods of investigation.
Vacunal cover in children 12 to 47 months old of social and economic 1 and 2 layers in the urban zone of Cali, year 2002.
Authors: Rojas Jorge H. , Zapata Helmer , Alzate Alberto , Rodríguez Álvaro 
Published: July 2024

Objective: To estimate prevalence of complete vaccination sketch in children of ages of 12 to 47 months old in strata 1 and 2 into urbane zone of Cali in the year of 2002 according to biologics and the categories of socio-demographic variables of the family, the mother and child. Methods: The research corresponded to a cross section survey. The sample size used in the estimation process was 4452 children, drawn from conglomerates combined with strata by means of probabilistic sampling. The information was analyzed with Epi-Info version 6.04, with the Csample module for complex samples analysis. Results: The vaccination coverage with complete sketch for the first year was 65.8 (62.1-69.5), with significative differences for one and two strata (x2=42.4, p< 0.05). In the group of 12 to 47 months the belower coverages according to biologic were for anti-Haemphilus influenzae type B and anti-hepatitis B 71.8% (68.6-75) and 92.2% (90.1-94.3) respectively. Statistical association was found (test x2, p< 0.05) in comparing vaccination coverages with mother’s age, mother’s schooling, mother’s working time, family income and type of health system affiliation. Conclusions: The vaccination coverages in the studied population for some biologics were below, bearing in mind that the rule established by Colombian Ministry of Social Protection is to keep coverages into a minimum of 95%.
Use of low birth weight as selecting criterion for the routine surveillance of congenital anomalies of infectious origin.
Authors: Bermúdez Antonio José , González Nohora E. , Ching Regina B. 
Published: July 2024

Introduction: Surveillance of congenital anomalies receives importance in the world-wide context of eradicating the congenital rubella syndrome. Objective: To identify the congenital anomalies and to consider the low birth weight a criterion to test IgM for the complex TORCH. Methodology: Surveillance of the congenital specific and non specific anomalies of the congenital rubella syndrome(CRS) and low birth weight in ten hospitals. It was considered as case, everything new born with some congenital anomaly or low weight for the gestational age. Serum tests for rubella, toxoplasmosis, citomegalovirus, herpes and parvovirus were practiced. For the negative cases cariotype was performed. Results: A total of 840 cases were selected, 669 by low weight for the gestational age, 52 by anomalies not related to CRS, 52; by anomalies that could be related to the CRS, 105. The most frequent anomalies were congenital heart diseases, 5.1%; hepatosplenomegalies, 3.9%; and microcephalies, 1.2%. There were confirmatory IgM titles for rubella in 0.5% of cases; toxoplasmosis 1.4%; citomegalovirus 1.5%; parvovirus 1.2%; herpes 0.5%; and positive test for congenital syphilis, 3.7%. In total there were 8.8% positive results for any congenital infectious disease. The relative risk for low birth weight having IgM positive rubella was RR = 2.83 (IC: 1.26:6.36-0.95). Discussion and conclusions: The surveillance for CRS, through the monitoring of febrile in the first year and by the presence of some specific congenital anomalies, could be improved in sensitivity by means of the routine monitoring of congenital anomalies, with the inclusion of low birth weight, like a selecting criterion to study the infectious agents.
New role of free radicals in exercise: another paradox?.
Authors: Urbina Bonilla Adriana del Pilar 
Published: July 2024

Introduction: Physical activity conduces to oxidative stress, which produces undesirable effects. However, it is well known that free radicals, when present in low concentrations, also have physiological effects in the exercise adaptation process. In addition, the majority of antioxidant supplementation studies, in spite of the fact of decreases oxidative stress, have failed to show a performance improving. Objectives: The goals of this review are to reinterpret the available evidence about the role of free radicals in exercise, and to analyze why antioxidant supplementation have not shown the expectable ergogenic effect. Methods: The following topics were reviewed: i) the free radical biology; ii) antioxidant systems; iii) exercise induced-oxidative stress; iv) oxidative stress and physical performance; and v) antioxidant supplementation and physical performance. Results: There is evidence that physical exercise is associated with excessive free radical production. Deleterious effects of free radicals in physical performance have been shown by in situ studies, although evidence in humans is also available. Physical exercise results in muscular hypoxia, which conduces to adaptative responses, probably through free radical-mediated HIF-1α stabilization. Moreover, a certain level of free radicals is necessary for optimal muscle contractility. Conclusions: Free radicals are necessary for exercise-induced hypoxia adaptation and muscle contraction, for that reason long term antioxidant supplementation interfere with its physiological role. This, explain why antioxidants decrease oxidative stress markers but fail to improve physical performance.
Editorial
Authors: Velasquez Palau Gabriel 
Published: July 2024

Por ello y animado por el derecho que espero tener dados los nexos tan estrechos que me unen con todos ustedes y con la Universidad, más que mirar el pasado, me atrevo a mirar hacia adelante y a plantearles algunos interrogantes pues creo que el momento que vive el país y el Sistema Universitario Colombiano, bien lo justifican.
Estimo, que el aspecto más importante que se debe analizar , es el referente a la misión, que en el inmediato futuro, debe cumplir la Universidad Colombiana. Principia ella apenas a superar aquel largo período en el que la Universidad sólo consistía en una agrupación más o menos coherente de Escuelas y Facultades independientes que tenían por único objetivo otorgar títulos profesionales que permiten a los jóvenes egresados escalar posiciones socio-económicas y abrirse paso en la lucha diaria. Se reconoce hoy que la Universidad debe salir de su aislamiento y convertirse en una de las principales agencias de transformación de nuestra comunidad. Se confía en que ella genere los conocimientos que se supone irán a acelerar ese proceso de cambio y se espera de ella que forme los dirigentes que mañana van a continuar y agilizar en forma constructiva y ordenada ese necesario movimiento de transformación.
CLUSTERING MODEL OF LOW-STRUCTURED TEXT DATA
Authors: Отраднов К.К. , Жуков Д.О. , Новикова О.А. 
Published: July 2024

В статье предложена модель кластеризации коллекций новостных текстовых сообщений, а также соответствующий алгоритм кластеризации «bubble trap». Суть предлагаемого подхода заключается в разделения всего векторного пространства текстовых документов на оболочки смысловых кластеров с минимальными ограничениями на признаки отбора таким образом, что объем смыслового кластера и положение его центра остаются неизменными в процессе добавления в него новых векторов, а критерием соотнесения является заданная постоянная метрика точности.
The article proposes a clustering model for collections of news text messages, as well as the corresponding bubble trap clustering algorithm. The essence of the proposed approach is to divide the entire vector space of text documents into shells of semantic clusters with minimal restrictions on the selection criteria in such a way that the volume of the semantic cluster and the position of its center remain unchanged in the process of adding new vectors to it, and the criterion of affiliation is a given constant accuracy metric.
ON MECHANISMS OF INVESTMENT SUPPORT OF INFRASTRUCTURE PROJECTS OF THE CHINESE INITIATIVE "ONE BELT, ONE WAY" AND DIGITAL RAILWAY TECHNOLOGIES
Authors: Ларин О.Н. , Куприяновский В.П. 
Published: July 2024

В статье рассматриваются инфраструктурные проекты, которые Китай предлагает участникам инициативы «Один пояс, Один путь». К числу наиболее масштабных инфраструктурных проектов, которые предлагаются участникам инициативы «Один пояс, Один путь», относится строительство Высокоскоростных железнодорожных магистралей. Проекты Высокоскоростных железнодорожных магистралей рассматриваются как часть программы «Пояс и путь», которая предусматривает развитие трансконтинентальной транспортной сети, соединяющей Западную Европу с Юго-Восточной Азией через КНР. В работе подробно рассматривается финансирование этого проекта. Необходимый объём финансирования предоставляют китайские инвесторы, что, как правило, предполагает получение компаниями из КНР дополнительных преимуществ на рынках стран вдоль маршрута «Пояса и пути». В статье предлагается рассматривать этот проект не только с точки зрения транзита между Европой и Китаем, но и с учетом перевозок между странами, внутри стран и быстро растущих городов. Это позволит изменить парадигму рассмотрения таких проектов на более быструю и сбалансированную модель финансирования, а также получать практические результаты в сжатые сроки и с быстрой окупаемостью инвестиций. При реализации инфраструктурных проектов соблюдение требований по глубокой локализации производства подвижного состава и оборудования, привлекаемых материальных и трудовых ресурсов, не должно зависеть из источника инвестиций и его национальной принадлежности.
The article considers infrastructural projects, which China offers participants of the "One Belt, One Way" initiative. Among the most ambitious infrastructure projects that are offered to participants of the “One-Belt, One-Way” initiative includes the construction of high-speed railways. High-Speed Railroad Projects are considered as part of the "One-Belt, One-Way " program, which provides for the development of a transcontinental transport network connecting Western Europe with South-East Asia through the People’s Republic China. The work details the financing of this project. The necessary volume of financing is provided by Chinese investors, which, as a rule, implies the receipt by companies from China of additional advantages in the markets of countries along the route "Belts and paths". The article proposes to consider this project not only from the point of view of transit between Europe and China, but also taking into account transport between countries, within countries and rapidly growing cities. This will change the paradigm of considering such projects for a faster and more balanced financing model, and also get practical results in a short time and with a quick return on investment. When implementing infrastructure projects, compliance with the requirements for the deep localization of production of rolling stock and equipment, attracted material and labor resources, should not depend on the source of investment and its nationality.
UML-SPECIFICATION OF COMPUTERIZED ENVIRONMENT FOR TEACHING OF SOFTWARE ENGINEERING
Authors: Гагарин А.П. , Иванов Е.В. 
Published: July 2024

Обобщённая модель передачи знаний по основным областям программной инженерии от преподавателя к учащемуся представлена в нотации языка UML как основа для проектирования и конструирования компьютерной среды, обеспечивающей как подготовку дидактических материалов, так и их применение в процессах контактного обучения программной инженерии. Рассматриваемая модель учитывает основные проблемы, встающие в процессе преподавания программной инженерии, в частности, преобладание примеров над правилами в контексте лекций, настоятельная потребность в доведении примеров программ до выполнения в ходе их демонстрации, необходимость обсуждения больших фрагментов программ, превышающих размеры экрана. Решения представлены в виде UML-спецификацию типового продукта для поддержки преподавания программной инженерии. Спецификация включает общую диаграмму прецедентов, диаграмму классов компьютеризованного учебного пособия, диаграмму классов среды для формирования таких пособий, диаграммы последовательностей, представляющих взаимодействие классов при инициализации продукта.
A generalized model of knowledge transferring on main areas of software engineering from a lecturer to the discipuli is represented in UML-notation as basis for design and construction of computerized environment for contact teaching in software engineering and preparation of corresponding didactical materials.The issue addresses main problems of teaching in software engineering, such as: predominance of samples over rools in a typical lecture context, imperative need of live program demos carried through execution, consideration of program samples exceeding screen size. Solutions of the probems are presented as UML-specification of a software product intended for support of teaching processes. The specification includes a general use case diagram, class diagram of online manual, class diagram of an environment providing creation of online manuals and sequence diagrams depicting cooperation of classes during initialization of the product.
ALGORITHM FOR NAVIGATION OF UNMANNED AERIAL VEHICLES FOR MONITORING OF FOREST ECOSYSTEMS
Authors: Неретина В.В. , Ефанов В.Н. , Фетисов В.С. 
Published: July 2024

Рассматривается задача навигации беспилотных летательных аппаратов при осуществлении мониторинга лесных экосистем. Цель данного исследования состоит в разработке алгоритмов навигации и формирования безопасных траекторий автономного полета БПЛА в условиях многочисленных помех и препятствий. Проводится анализ современных средств мониторинга лесных экосистем. Для решения задачи навигации предлагается использовать технологии «машинного зрения». Эти технологии позволяют находить и локализовать на текущем изображении опасные объекты сцены для формирования сигналов управления движением БПЛА по безопасным траекториям. Разрабатывается алгоритм сегментации изображения окружающей обстановки на основе статистического анализа гистограмм яркости областей изображения. Данный алгоритм позволяет осуществить зонирование воздушного пространства по уровню опасности с использованием введенной совокупности текстурных признаков. Приводится оценка эффективности алгоритма сегментации изображения лесного массива на основе вычисления статистических текстурных характеристик. Излагается алгоритм формирования траектории движения низколетящих БПЛА для уклонения от опасности.
The problem of navigation of unmanned aerial vehicles in the monitoring of forest ecosystems is considered. The purpose of this study is to develop algorithms for navigation and formation of safe trajectories of Autonomous flight of UAV in conditions of numerous interference and obstacles. The analysis of modern means of monitoring of forest ecosystems is carried out. To solve the problem of navigation it is proposed to use the technology of «machine vision». These technologies allow us to fi nd and localize dangerous objects of the scene on the current image to generate control signals of the UAV movement along safe trajectories. The algorithm of segmentation of the image of the environment on the basis of statistical analysis of histograms of brightness of areas of the image is developed. This algorithm makes it possible to carry out zoning of the air space according to the level of danger using the introduced set of texture features. The estimation of effi ciency of the algorithm of segmentation of the image of forest on the basis of calculation of statistical textural characteristics is given. The algorithm of formation of the trajectory of lowflying UAV to avoid danger is presented.