bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small proline‐rich repeat protein 3 enhances the sensitivity of esophageal cancer cells in response to DNA damage‐induced apoptosis
Authors: Luo Aiping , Chen Hongyan , Ding Fang , Zhang Yu , Wang Mingrong , Xiao Zefen , Liu Zhihua 
Published: June 2013

Small proline‐rich repeat protein 3 (SPRR3) has been linked with the altered chemoradiosensitivity, however the underlying molecular mechanisms remain elusive. Here, we report that ectopic overexpression of SPRR3 enhanced the sensitivity of cells in response to DNA damage‐induced apoptosis via loss of mitochondrial membrane potential (MMP), and increasing activation of caspase 3 in human esophageal cancer cell lines. Conversely, siRNA knockdown of SPRR3 reduced apoptosis. We found that SPRR3 was localized in mitochondria and interacted with Bcl‐2 in vivo, thus facilitating Bax mitochondrial translocation and the subsequent release of cytochrome c, and thereby enhancing cell sensitivity to DNA damage stimuli. In clinical samples, expression of SPRR3 was associated with the pathologic response (P = 0.007 in radiotherapy group, P = 0.035 in preoperative radiotherapy group) and good survival of patients with locally advanced esophageal squamous cell carcinoma (ESCC, P = 0.008). Taken together, our results implicate that SPRR3 might serve as a radiation‐sensitive predictor of ESCC.
NONTRIVIAL SOLUTIONS FOR STURM–LIOUVILLE SYSTEMS VIA A LOCAL MINIMUM THEOREM FOR FUNCTIONALS
Authors: BONANNO GABRIELE , HEIDARKHANI SHAPOUR , O’REGAN DONAL 
Published: June 2013

AbstractIn this paper, employing a very recent local minimum theorem for differentiable functionals, the existence of at least one nontrivial solution for a class of systems of $n$ second-order Sturm–Liouville equations is established.
A NEW UPPER BOUND FOR
Authors: TRUDGIAN TIMOTHY 
Published: June 2013

AbstractIt is known that $\zeta (1+ it)\ll \mathop{(\log t)}\nolimits ^{2/ 3} $ when $t\gg 1$. This paper provides a new explicit estimate $\vert \zeta (1+ it)\vert \leq \frac{3}{4} \log t$, for $t\geq 3$. This gives the best upper bound on $\vert \zeta (1+ it)\vert $ for $t\leq 1{0}^{2\cdot 1{0}^{5} } $.
Contracting with Nonfinancial Stakeholders and Corporate Capital Structure: The Case of Product Warranties
Authors: Kale Jayant R. , Meneghetti Costanza , Shahrur Husayn 
Published: June 2013

AbstractWe investigate the relation between a firm’s product warranty level and its leverage. We find that leverage relates negatively to the warranty level and that this relation is robust to controls for endogeneity and self-selection into offering warranties. The negative warranty-leverage relation obtains only in the subsample of firms in the manufacturing industries. We also show that firms with warranties have the lowest debt levels, firms without warranties but operating in industries where other firms offer warranties on average carry higher debt, and firms in industries where no firm offers a warranty have the highest debt levels.
Uncommon and rare causes of vocal fold paralysis detected via imaging
Authors: Sobrino-Guijarro B , Virk J S , Singh A , Lingam R K 
Published: June 2013

AbstractBackground:Cross-sectional imaging can be used to trace the course of the vagus nerve and its laryngeal branches to detect many of the causes of vocal fold paralysis. The most frequent aetiologies are surgical injury and tumoural involvement of the recurrent laryngeal nerve anywhere along its course.Method:This review article focuses on the uncommon and rare causes of vocal fold paralysis that have been detected or diagnosed on cross-sectional imaging.Results and conclusion:Uncommon causes included a tortuous oesophagus, tracheal diverticulum, cervical osteophytes and cardiovocal syndrome. These examples are presented with clinical case histories and radiological appearances, and are discussed in the context of the current literature.
Are healthcare workers at higher risk of HIV infection than the general population in Burkina Faso?
Authors: KIRAKOYA-SAMADOULOUGOU F. , FAO P. , YARO S. , DEFER M.-C. , MEDA N. , ROBERT A. , NAGOT N. 
Published: June 2013

SUMMARYIn order to assess the HIV prevalence in healthcare workers (HCWs) in Burkina Faso, we conducted a national survey in 97 health facilities from urban and rural areas. Of 1570 HCWs who agreed to participate, 1013 (64·5%) provided a urine sample for HIV testing. The crude prevalence of HIV in HCWs was 3·5% (95% CI 2·3–4·6). HIV prevalence was 0·7% in students and trainees, 3·8% in nurses and midwives, 4·5% in administrative workers, and 4·6% in laboratory workers. After age and area standardization, men from the Demographic Health Survey (DHS) had a similar HIV prevalence (2·3%, 95% CI 1·4–2·9) as male HCWs (2·5%, 95% CI 1·1–4·0), while female HCWs were more infected (4·5%, 95% CI 2·5–6·0) than women from the DHS (2·1%, 95% CI 1·3–2·4). A voluntary counselling and testing (VCT) programme should be specifically implemented and adapted for female HCWs.
The PathoChip, a functional gene array for assessing pathogenic properties of diverse microbial communities
Authors: Lee Yong-Jin , van Nostrand Joy D , Tu Qichao , Lu Zhenmei , Cheng Lei , Yuan Tong , Deng Ye , Carter Michelle Q , He Zhili , Wu Liyou , Yang Fang , Xu Jian , Zhou Jizhong 
Published: June 2013

Abstract
Pathogens present in the environment pose a serious threat to human, plant and animal health as evidenced by recent outbreaks. As many pathogens can survive and proliferate in the environment, it is important to understand their population dynamics and pathogenic potential in the environment. To assess pathogenic potential in diverse habitats, we developed a functional gene array, the PathoChip, constructed with key virulence genes related to major virulence factors, such as adherence, colonization, motility, invasion, toxin, immune evasion and iron uptake. A total of 3715 best probes were selected from 13 virulence factors, covering 7417 coding sequences from 1397 microbial species (2336 strains). The specificity of the PathoChip was computationally verified, and approximately 98% of the probes provided specificity at or below the species level, proving its excellent capability for the detection of target sequences with high discrimination power. We applied this array to community samples from soil, seawater and human saliva to assess the occurrence of virulence genes in natural environments. Both the abundance and diversity of virulence genes increased in stressed conditions compared with their corresponding controls, indicating a possible increase in abundance of pathogenic bacteria under environmental perturbations such as warming or oil spills. Statistical analyses showed that microbial communities harboring virulence genes were responsive to environmental perturbations, which drove changes in abundance and distribution of virulence genes. The PathoChip provides a useful tool to identify virulence genes in microbial populations, examine the dynamics of virulence genes in response to environmental perturbations and determine the pathogenic potential of microbial communities.
Impact of PPAR-α induction on glucose homoeostasis in alcohol-fed mice
Authors: Lebrun Valérie , Molendi-Coste Olivier , Lanthier Nicolas , Sempoux Christine , Cani Patrice D. , van Rooijen Nico , Stärkel Peter , Horsmans Yves , Leclercq Isabelle A. 
Published: June 2013

Alcohol consumption is a major cause of liver disease. It also associates with increased cardiovascular risk and Type 2 diabetes. ALD (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression. In NAFLD, steatosis, lipotoxicity and liver inflammation participate to hepatic insulin resistance. The aim of the present study was to verify the effect of alcohol on hepatic insulin sensitivity and to evaluate the role of alcohol-induced steatosis and inflammation on glucose homoeostasis. C57BL/6J mice were fed for 20 days a modified Lieber–DeCarli diet in which the alcohol concentration was gradually increased up to 35% of daily caloric intake. OH (alcohol liquid diet)-fed mice had liver steatosis and inflammatory infiltration. In addition, these mice developed insulin resistance in the liver, but not in muscles, as demonstrated by euglycaemic–hyperinsulinaemic clamp and analysis of the insulin signalling cascade. Treatment with the PPAR-α (peroxisome-proliferator-activated receptor-α) agonist Wy14,643 protected against OH-induced steatosis and KC (Kupffer cell) activation and almost abolished OH-induced insulin resistance. As KC activation may modulate insulin sensitivity, we repeated the clamp studies in mice depleted in KC to decipher the role of macrophages. Depletion of KC using liposomes-encapsuled clodronate in OH-fed mice failed both to improve hepatic steatosis and to restore insulin sensitivity as assessed by clamp. Our study shows that chronic alcohol consumption induces steatosis, KC activation and hepatic insulin resistance in mice. PPAR-α agonist treatment that prevents steatosis and dampens hepatic inflammation also prevents alcohol-induced hepatic insulin resistance. However, KC depletion has little impact on OH-induced metabolic disturbances.
Recruiting parents, retaining families
Authors: Little Micquel , Price Michelle 
Published: June 2013

PurposeThe purpose of this paper is to share St John Fisher College Library's marketing approach to recruiting and retention of parents within the higher education community.Design/methodology/approachThe objectives of this paper are achieved by connecting local experiences with other parent initiatives on university campuses throughout the country. The paper takes the approach of addressing marketing strategies for recruitment and retention of parents, while also including opportunities for these strategies to be applied.FindingsThe findings display the library's ability to contribute to their campus recruitment and retention goals while assisting parents in connecting to the library in an informational and emotional capacity.Originality/valueThis paper presents the academic library's perspective on a higher education initiative focused on targeting parents during the recruitment and retention processes. Academic librarians will find the most value in this paper by finding step‐by‐step guidelines for implementing the experiences shared by St John Fisher College's library.
Library and university governance: partners in student success
Authors: Lynn Mix Vickie 
Published: June 2013

PurposeThis paper's aim is to examine the value of library participation in institutional governance in the implementation of a comprehensive model for student success at a research university.Design/methodology/approachThe paper provides a case study comparing the historical and current governance structure in a high research university, the relationship between a new governance structure and the implementation of a comprehensive student success model and the inclusion of the library in creating, implementing and participating in student success initiatives.FindingsParticipation in university shared governance enhances the library's role in contributing to student success, retention, progression and graduation.Originality/valueThe paper contributes to the discussion of the value of academic libraries to student success efforts in retention, progression and graduation for university students.
The American Community Survey: practical considerations for researchers
Authors: Donnelly Francis P. 
Published: June 2013

PurposeThis paper seeks to provide researchers and librarians with an overview of the US Census Bureau's American Community Survey (ACS), with a specific focus on practical issues that users must face when choosing and using ACS datasets.Design/methodology/approachEach of the following issues are explored subsequent to a general overview of the ACS: choosing among census datasets from different census programs, interpreting and choosing between the different ACS period estimates, selecting census geography, understanding and recalculating margins of error, and accessing the data. Samples of ACS tables and formulas for creating derived estimates are used to illustrate how to interpret and work with the data.FindingsThe ACS datasets are fundamentally different from the decennial census as they are period estimates created from rolling sample surveys. The ACS has a steeper learning curve; this complexity is due in part to the number of choices users must make between datasets, but the primary challenge is learning how to understand and work with estimates as opposed to population counts.Originality/valueWhile other papers have discussed the benefits and challenges of the ACS, this paper is structured around the practical issues that researchers must face when using it. Special consideration is given to calculating derived estimates using spreadsheet formulas, as this is a key task that many users will need to perform and spreadsheets are the most likely tool users will employ to manipulate the data.
Barriers to export: the power of organisational factors
Authors: Vila López Natalia 
Published: June 2013

PurposeThis paper aims to investigate the export strategy of international business by explicitly comparing exporting firms with the non‐exporting ones, given that they supposedly differ due to the presence of organizational export barriers.Design/methodology/approachThis study uses a database with more than 55,000 registered enterprises from all commercial sectors to demonstrate that two strategic groups really exist: exporters and non‐exporters.FindingsThe findings support the existence of both groups, which differ significantly regarding three kinds of organizational factors that act as mobility barriers constraining migration of non‐exporting enterprises to the exporting group: size (total sales and number of employees), antiquity and export involvement.Practical implicationsThe author's results explain why non‐exporters are less likely to evolve into regular exporting firms. This is an issue of paramount importance in international marketing, since the way these barriers are perceived by non‐exporters often determines their future engagement and performance in international business activities.Originality/valueFirstly, the paper adds a new viewpoint in as far as both options – to export or not to export – are considered as alternative strategies, and, consequently, as alternative strategic groups. Secondly, this study adds further slant by calling upon the resources of a large database of enterprises that belongs to a particular country: Spain.
Mathematical model for dispersion and diffusion of chemically reactive pollutants from various sources into a boundary layer with dry deposition
Authors: Khan Yasir , Shekhu Moka , Sulochana C. 
Published: June 2013

PurposeThe purpose of this paper is to propose a mathematical model for dispersion and diffusion of chemically reactive primary pollutants emitted from an elevated line sources into a stable atmospheric boundary layer with generalized wind velocity of quadratic function of vertical height z.Design/methodology/approachThe governing partial differential equations are converted into the two‐dimensional time dependent partial differential equation by suitable choice of meteorological parameters and non‐dimensional variables, which is solved by the multiple inverse Laplace transform through Green's Function technique.FindingsThe three different types’ sources, viz. continuous, an instantaneous and step‐function type sources are studied. The pollutants considered are chemically reactive primary pollutants emitted from the above sources. In many previous works, solutions are obtained through numerical technique or numerical inversion of the Laplace transform; but here, an analytical method is carried out to find the exact solution through multiple inversion of Laplace transform, which yields an effective and accurate solution.Originality/valueThe paper describes how the authors obtained exact solutions for the elevated line sources into a stable atmospheric boundary layer arising in the chemically reactive primary pollutants model by inverse Laplace transform through Green's Function technique. The graphical results show that this method is very accurate. The gaseous pollutants converted into particulate matter and settled on surface terrain are also considered in this theoretical model.
A healthy scepticism towards water in South Australia
Authors: Willis Eileen , Pearce Meryl , Mamerow Loreen , Jorgensen Brad , Martin John 
Published: June 2013

PurposeThis paper examines citizen trust at both a rational and affect level in the water utility provider, SA Water.Design/methodology/approachThe study draws on data from a CATI of approximately 500 residents in two urban and rural locations.FindingsCitizens have a healthy scepticism toward the utility provider suggesting they make a distinction between the capacity of SA Water to provide safe drinking water, and the political willingness of the government to plan for long‐term sustainability.Research limitations/implicationsThe conduct of research on topics of a political nature may be viewed by respondents as a political act although it is possible to see the views expressed as representative. Research conducted during times of heightened awareness, such as during a drought when water restrictions are in place, may generate strong feelings of anger in government, but may not be a true measure of citizen trust in the provider.Practical implicationsThe paper shows that trust in utility providers may vary according to social situations.Social implicationsEncouraging citizen trust in the water supply requires education in the science used to ensure safety, but also transparent regulation for ensuring risk management.Originality/valueThe study points to possible shifts in citizen trust in water providers depending on climatic conditions, the role of the utility provider, and the reputation of the government as a regulator and planner.
Intensified activation for disadvantaged welfare recipients in Germany: does it work?
Authors: Dengler Katharina , Hohmeyer Katrin , Moczall Andreas , Wolff Joachim 
Published: June 2013

PurposeThe purpose of this paper is to analyse the implementation and effectiveness of an intensified activation scheme for very disadvantaged welfare recipients in Germany, used as a targeting device for a very generous wage subsidy (JobPerspective).Design/methodology/approachUsing administrative data and a difference‐in‐difference approach, the authors analyse the implementation of the activation scheme and its impact on various labour market outcomes. To ensure that target and comparison group are comparable over time, the authors control for various individual, household and regional characteristics.FindingsThe activation of the target group of disadvantaged welfare recipients is modestly intensified directly after the scheme's introduction. This does not improve the prospects of the target group to work in regular jobs, but – as a first step – in subsidized jobs. Considering a later period, evidence was found for broader activation efforts together with some gains in the regular employment for disadvantaged welfare recipients. Overall, the results suggest that the implementation of activation for disadvantaged welfare recipients, as well as employment gains, need time.Originality/valueThis study analyses whether and how a scheme of intensified activation that leaves its design to local actors, without providing additional funding, makes job centres implement such a policy.
Living arrangements among older population and perceptions on old age assistance among adult population in India
Authors: Ahamed Golandaj Javeed , Goli Srinivas , Chandra Das Kailash 
Published: June 2013

PurposeThe purpose of this paper is to investigate the pattern of living arrangements among the older population and perception about old age support in the Indian adult population.Design/methodology/approachThis study used India Human Development Survey (IHDS), 2004‐2005 data for empirical analyses. Bivariate and multivariate models are used as statistical analyses for this study. This study is an evidence‐based interpretation of living arrangements among older persons and perception about future living arrangement and financial assistance among current adult people.FindingsIt was found that 17 percent of older population lived with their spouse only; only 2 percent lived singly, and the rest of 85 percent elderly were living in co‐residence with children. A majority of women respondents are expecting their sons to live with them, to take care and provide financial and emotional support in their old age. This indicates that the family will continue to be a significant social institution for the care and support for the older population in India.Originality/valueThis study is the first of its kind, which, in addition, to living arrangement patterns of the older population, provides some insight about the expectations of the current adult generation about living and financial preferences in old age.
Web services in interlibrary loan transactions: the Spanish GTBib network
Authors: Rodríguez‐Gairín Josep‐Manuel 
Published: June 2013

PurposeThe purpose of this paper is to report on the use of web services to transmit requests and documents in the interlibrary loan (ILL) services of Spanish universities.Design/methodology/approachThe paper describes the problems involved in the use of email for communication between ILL services and presents a solution based on SOAP/XML technologies using standard protocols such as ISO 10160/10161, the OpenURL protocol and the NISO circulation interchange protocol (NCIP).FindingsThe solution presented provides real data on ILL transactions and on the use of options for communication between services, and will be used to further develop the gathering of statistical data on the service.Practical implicationsThis technology provides instant confirmation of receipt of messages, eliminating the uncertainty of using email. It also synchronizes the status of requests between the requesting and supplying institutions at all times.Originality/valueAlthough the use of web services in ILL transactions is suggested in the NCIP, their practical application has been limited and isolated. This paper describes their implementation in Spain in practically all university libraries, the National Library and many medical libraries.
Copyright clearing methods for electronic document delivery in Korea
Authors: Yoo Suhyeon , Kim Hyesun 
Published: June 2013

PurposeThe purpose of this paper is to summarize the current Korean copyright law and its effect on electronic document delivery services in Korea, and to recommend solutions for Korean libraries and information centers.Design/methodology/approachThe authors present information based on their own professional experience at a national document supply center.FindingsKorean libraries have five options for pursuing copyright clearance for materials published outside of Korea: negotiate an agreement directly with publishers; establish an agreement with, and pay royalties to, copyright collectives; establish bilateral treaties with national copyright collectives; establish a framework agreement with the organizations representing copyright holders; and incorporate extended collective licensing into the Korean copyright law.Originality/valueThe Korean copyright law was amended in 2011 and this paper presents the most current research on the law's impact on electronic document delivery services in Korea.