bluuebunny/crossref_metadata_2025_split huggingface dataset:
AGILE: A terminal energy efficient scheduling method in mobile cloud computing
Authors: Chen Chao , Bao Weidong , Zhu Xiaomin , Ji Haoran , Xiao Wenhua , Wu Jianhong 
Published: July 2015

AbstractWith the development of mobile telecommunication technology, mobile phones have become a necessary tool in daily life and provided us many conveniences. Meanwhile, the huge number of cell phones constitute a potential high performance data processing system, called mobile cloud computing, to strengthen capacity for individual devices. Many researchers have studied about the architectures and scheduling algorithms of mobile cloud computing. However, little work has been performed about how to schedule mobile application tasks in data centers to extend battery life for mobile terminals. To address this issue, we investigate agent models, mobile energy consumption models and data transmission models under different connection environments. Based on which, we propose a novel terminal energy efficient scheduling method (AGILE for short). AGILE compares energy consumption in cloud execution and mobile execution according to the actual wireless environment, then makes energy‐efficient decisions. Extensive experiments are conducted to evaluate the performance of the AGILE under different wireless channels, and the performance impact on different parameters are studied. The experimental results indicate that the proposed method can save mobile devices' energy effectively. Copyright © 2015 John Wiley & Sons, Ltd.
Analysis of geological effects on methane adsorption capacity of continental shale: a case study of the Jurassic shale in the Tarim Basin, northwestern China
Authors: Gao Xiaoyue , Liu Luofu , Jiang Fujie , Wang Ying , Xiao Fei , Ren Zeying , Xiao Zhengyang 
Published: July 2015

AbstractThe Jurassic shale is an important source rock for the found gas reservoirs in the Tarim Basin, northwestern China, but has never been researched for shale gas potential. The geological effects on methane adsorption capacity for the gas shale have been investigated in this paper through the geochemical, mineralogical and adsorption analyses on samples from wells and sections. The methane adsorption capacity ranges from 0.58 to 16.57 cm3/g, and the total organic carbon (TOC) content is between 0.5 and 13.5 wt%. The organic maturity measured by Tmax is between 410 °C (immature) and 499 °C (overmature). The methane adsorption capacity of the Jurassic continental shale in the Tarim Basin is affected by many geological factors, including the TOC content, organic matter maturity, mineral composition, surface area and pore size distribution. The TOC content is the most significant factor with a positive effect on the adsorption capacity of the Jurassic shale, and the influence varies piecewise according to the TOC content. The TOC content contributes much more to the methane adsorption capacity of organic‐rich shale samples (TOC content > 0.7 wt%) than to the organic‐lean samples (TOC content < 0.7 wt%). The mineral composition is a secondary factor, and the abundance of clay content has a positive effect on the methane adsorption capacity despite its relatively weaker adsorption ability compared to TOC. The pore size distribution has different effects on surface area and pore volume. Mesopores and micropores provide the major surface area and are mainly derived from TOC and illite, which has a positive influence on the adsorption capacity. Mesopores and macropores offer the major pore volume and are mainly formed by illite, which is the major contributor for pore volume rather than surface area. In addition, the TOC and illite contents of the Jurassic shale in the Tarim Basin are closely related to the origin, maturity and diagenesis evolution of the shale: (1) both TOC and illite content variations are related to the different provenances and depositional environments of shale; (2) the decrease of TOC content with increasing maturity is also partly attributed to hydrocarbon generation; and (3) the increase of illite content with increasing maturity is due to illitization in the diagenesis of shale. Copyright © 2015 John Wiley & Sons, Ltd.
The subthalamic nucleus during decision‐making with multiple alternatives
Authors: Keuken Max C. , Van Maanen Leendert , Bogacz Rafal , Schäfer Andreas , Neumann Jane , Turner Robert , Forstmann Birte U. 
Published: July 2015

AbstractSeveral prominent neurocomputational models predict that an increase of choice alternatives is modulated by increased activity in the subthalamic nucleus (STN). In turn, increased STN activity allows prolonged accumulation of information. At the same time, areas in the medial frontal cortex such as the anterior cingulate cortex (ACC) and the pre‐SMA are hypothesized to influence the information processing in the STN. This study set out to test concrete predictions of STN activity in multiple‐alternative decision‐making using a multimodal combination of 7 Tesla structural and functional Magnetic Resonance Imaging, and ancestral graph (AG) modeling. The results are in line with the predictions in that increased STN activity was found with an increasing amount of choice alternatives. In addition, our study shows that activity in the ACC is correlated with activity in the STN without directly modulating it. This result sheds new light on the information processing streams between medial frontal cortex and the basal ganglia. Hum Brain Mapp 36:4041–4052, 2015. © 2015 Wiley Periodicals, Inc.
Decision‐making style, nicotine and caffeine use and dependence
Authors: Phillips James G. , Ogeil Rowan P. 
Published: July 2015

RationaleAs therapeutic interventions are being developed utilising telehealth and mobile phones, it is important to understand how substance‐dependent individuals will respond to offers of online assistance.ObjectivesThe present paper considered the following: (1) how decision‐making style is associated with use and dependence upon commonly used stimulants and (2) how it influences behavioural responses to electronic offers of further information about these drugs.MethodAn online survey examined patterns of nicotine and caffeine use, administered Severity of Dependence Scales for caffeine and nicotine and assessed decision‐making style using the Melbourne Decision Making Questionnaire and mood using the Kessler Distress Scale. Upon completing these scales, the 181 participants with a mean age of 28.14 years were offered further information online.ResultsStimulant dependence was associated with psychological distress. Caffeine dependence was linked to hypervigilance (panic). Decisional self‐esteem varied with stimulant dependence and Kessler Distress Scale score. Participants with high decisional self‐esteem declined electronic offers of further information.ConclusionConfidence rather than defensive avoidance was a factor in reducing information‐seeking behaviours on the Internet. Copyright © 2015 John Wiley & Sons, Ltd.
High affinity targeting of CD23 inhibits IgE synthesis in human B cells
Authors: Fellmann Marc , Buschor Patrick , Röthlisberger Silvan , Zellweger Fabian , Vogel Monique 
Published: July 2015

AbstractThe low‐affinity IgE receptor FcϵRII (CD23) is part of the regulatory system controlling IgE synthesis in human B cells and exists in membrane and soluble forms. Binding of IgE to CD23 has been described to have stabilizing effects and to prevent cleavage of CD23. Previous experiments using anti‐CD23 antibodies reduced IgE synthesis but were difficult to interpret as the antibody Fc part might also mediate feedback mechanisms. The purpose of this study was to investigate the regulatory role of CD23, by using designed ankyrin repeat proteins (DARPins) that specifically recognize CD23. Anti‐CD23 DARPins were isolated by ribosome display and were produced as monovalent and bivalent constructs. Affinities to CD23 were measured by surface plasmon resonance. IgE synthesis and up‐regulation of CD23 in human peripheral B cells were induced by IL‐4 and anti‐CD40 antibody. We assessed CD23 expression and its stabilization by FACS and used an ELISA for detecting soluble CD23. IgE synthesis was measured by ELISA and real‐time PCR. Surface plasmon resonance revealed affinities of the DARPins to CD23 in the pico‐molar range. Anti‐CD23 DARPins strongly inhibited binding of IgE to CD23 and share thus a similar binding epitope as IgE. The DARPins stabilized membrane CD23 and reduced IgE synthesis in an isotype specific manner. Furthermore, the anti‐CD23 DARPins decreased IgE transcript through inhibition of mature Cϵ RNA synthesis suggesting a posttranscriptional control mechanism. This study demonstrates that targeting CD23 alone is sufficient to inhibit IgE synthesis and suggests that a negative signaling occurs directly through the CD23 molecule.
CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids
Authors: Dahlin Amber , Denny Joshua , Roden Dan M. , Brilliant Murray H. , Ingram Christie , Kitchner Terrie E. , Linneman James G. , Shaffer Christian M. , Weeke Peter , Xu Hua , Kubo Michiaki , Tamari Mayumi , Clemmer George L. , Ziniti John , McGeachie Michael J. , Tantisira Kelan G. , Weiss Scott T. , Wu Ann Chen 
Published: July 2015

AbstractInhaled corticosteroids (ICS) are the most effective controller medications for asthma, and variability in ICS response is associated with genetic variation. Despite ICS treatment, some patients with poor asthma control experience severe asthma exacerbations, defined as a hospitalization or emergency room visit. We hypothesized that some individuals may be at increased risk of asthma exacerbations, despite ICS use, due to genetic factors. A GWAS of 237,726 common, independent markers was conducted in 806 Caucasian asthmatic patients from two population‐based biobanks: BioVU, at Vanderbilt University Medical Center (VUMC) in Tennessee (369 patients), and Personalized Medicine Research Project (PMRP) at the Marshfield Clinic in Wisconsin (437 patients). Using a case–control study design, the association of each SNP locus with the outcome of asthma exacerbations (defined as asthma‐related emergency department visits or hospitalizations concurrent with oral corticosteroid use), was evaluated for each population by logistic regression analysis, adjusting for age, gender and the first four principal components. A meta‐analysis of the results was conducted. Validation of expression of selected candidate genes was determined by evaluating an independent microarray expression data set. Our study identified six novel SNPs associated with differential risk of asthma exacerbations (P < 10−05). The top GWAS result, rs2395672 in CMTR1, was associated with an increased risk of exacerbations in both populations (OR = 1.07, 95% CI 1.03–1.11; joint P = 2.3 × 10−06). Two SNPs (rs2395672 and rs279728) were associated with increased risk of exacerbations, while the remaining four SNPs (rs4271056, rs6467778, rs2691529, and rs9303988) were associated with decreased risk. Three SNPs (rs2395672, rs6467778, and rs2691529) were present in three genes: CMTR1, TRIM24 and MAGI2. The CMTR1 mRNA transcript was significantly differentially expressed in nasal lavage samples from asthmatics during acute exacerbations, suggesting potential involvement of this gene in the development of this phenotype. We show that genetic variability may contribute to asthma exacerbations in patients taking ICS. Furthermore, our studies implicate CMTR1 as a novel candidate gene with potential roles in the pathogenesis of asthma exacerbations.
A simulation‐based resident‐as‐teacher program: The impact on teachers and learners
Authors: Miloslavsky Eli M. , Sargsyan Zaven , Heath Janae K. , Kohn Rachel , Alba George A. , Gordon James A. , Currier Paul F. 
Published: July 2015

BACKGROUNDResidency training is charged with improving resident teaching skills. Utilizing simulation in teacher training has unique advantages such as providing a controlled learning environment and opportunities for deliberate practice.OBJECTIVEWe assessed the impact of a simulation‐based resident‐as‐teacher (RaT) program.DESIGNA RaT program was embedded in an existing 8‐case simulation curriculum for 52 internal medicine (IM) interns. Residents participated in a workshop, then served as facilitators in the curriculum and received feedback from faculty.METHODSResidents' teaching and feed back skills were measured using a pre‐ and post‐program self‐assessment and post‐session and post‐curriculum evaluations by intern learners.SETTING/PARTICIPANTSForty‐one second‐ and third‐year residents participated in the study August 2013 to October 2013 at a single center.RESULTSPre‐ and post‐program teaching skills were assessed for 34 of 41 resident facilitators (83%) participating in 3.9 sessions on average. Partaking in the program led to improvements in resident facilitators' self‐reported teaching and feedback skills across all domains. The most significant improvement was in teaching in a simulated environment (2.81 to 4.16, P < 0.001). Interns rated the curriculum highly (81% “excellent,” 19% “good”) and reported that resident facilitators frequently utilized debriefing techniques covered in the RaT program.CONCLUSIONSOur simulation‐based RaT program offered a unique opportunity for deliberate practice of teaching skills in a controlled environment and led to improvements in resident facilitators' teaching and feed back skills. The simulation curriculum, facilitated by residents, was well received by the intern learners. Our program design may serve as a model for the development of simulation curricula and RaT programs within IM residencies. Journal of Hospital Medicine 2015;10:767–772. © 2015 Society of Hospital Medicine
Combination therapy with intra‐articular injection of mesenchymal stem cells and articulated joint distraction for repair of a chronic osteochondral defect in the rabbit
Authors: Harada Yohei , Nakasa Tomoyuki , Mahmoud Elhussein Elbadry , Kamei Goki , Adachi Nobuo , Deie Masataka , Ochi Mitsuo 
Published: July 2015

ABSTRACTThe present study investigated intra‐articular injection of bone‐marrow‐derived mesenchymal stem cells (MSCs) combined with articulated joint distraction as treatment for osteochondral defects. Large osteochondral defects were created in the weight‐bearing area of the medial femoral condyle in rabbit knees. Four weeks after defect creation, rabbits were divided into six groups: control group, MSC group, distraction group, distraction + MSC group, temporary distraction group, and temporary distraction + MSC group. Groups with MSC received intra‐articular injection of MSCs. Groups with distraction underwent articulated distraction arthroplasty. Groups with temporary distraction discontinued the distraction after 4 weeks. The rabbits were euthanized at 4, 8, and 12 weeks after treatment except temporary distraction groups which were euthanized at only 12 weeks. Histological scores in the distraction + MSC group were significantly better than in the control, MSC group or distraction group at 4 and 8 weeks, but showed no further improvement. At 12 weeks, the temporary distraction + MSC group showed the best results, demonstrating hyaline cartilage repair with regeneration of the osteochondral junction. In conclusion, joint distraction with intra‐articular injection of MSCs promotes early cartilage repair, and compressive loading of the repair tissue after temporary distraction stimulates articular cartilage regeneration. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1466–1473, 2015.
Hypoxia‐inducible factor 3‐alpha expression is associated with the stable chondrocyte phenotype
Authors: Markway Brandon D. , Cho Holly , Zilberman‐Rudenko Jevgenia , Holden Paul , McAlinden Audrey , Johnstone Brian 
Published: July 2015

ABSTRACTThe hypoxia‐inducible factors HIF‐1α and HIF‐2α are important regulators of the chondrocyte phenotype but little is known about HIF‐3α in cartilage. The objective of this study was to characterize HIF‐3α (HIF3A) expression during chondrocyte differentiation in vitro and in native cartilage tissues. HIF3A, COL10A1, and MMP13 were quantified in mesenchymal stem cells (MSCs) and articular chondrocytes from healthy and osteoarthritic (OA) tissue in three‐dimensional cultures and in human embryonic epiphyses and adult articular cartilage. HIF3A was found to have an inverse association with hypertrophic markers COL10A1 and MMP13 in chondrogenic cells and tissues. In healthy chondrocytes, HIF3A was induced by dexamethasone and increased during redifferentiation. By comparison, HIF3A expression was extremely low in chondrogenically differentiated MSCs expressing high levels of COL10A1 and MMP13. HIF3A was also lower in redifferentiated OA chondrocytes than in healthy chondrocytes. In human embryonic epiphyseal tissue, HIF3A expression was lowest in the hypertrophic zone. Distinct splice patterns were also found in embryonic cartilage when compared with adult articular cartilage and redifferentiated chondrocytes. These in vitro and in vivo findings suggest that HIF3A levels are indicative of the hypertrophic state of chondrogenic cells and one or more splice variants may be important regulators of the chondrocyte phenotype. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1561–1570, 2015.
Postoperative recurrence of papillary thyroid carcinoma with lymph node metastasis
Authors: Liu Feng‐Hsuan , Kuo Sheng‐Fong , Hsueh Chuen , Chao Tzu‐Chieh , Lin Jen‐Der 
Published: July 2015

Background and Objectives: The purpose of this study was to retrospectively analyze the features of patients with papillary thyroid carcinoma (PTC) presenting with neck lymph node (LN) metastasis.Methods: The study enrolled 909 patients with PTC who had undergone total thyroidectomy. After a median follow‐up of 14.6 years, 73 (8.0%) patients died of thyroid cancer. A total of 536 patients had the tumor confined to the thyroid (intra‐thyroid), 111 had lymph node (LN) metastasis, 225 showed soft tissue invasion, and 37 had distant metastasis.Results: Compared with the intra‐thyroid group, the group with LN metastases showed larger tumor size, higher postoperative thyroglobulin levels, advanced TNM stage, higher recurrence rates (5.2% vs. 31.5%), and higher disease‐specific mortality (1.3% vs. 12.6%). Of the 111 patients with PTC and LN metastases, 35 (31.5%) were diagnosed with recurrence during a mean follow‐up period of 16.9 ± 0.6 years. Among the 35 patients with recurrent PTC, 14 (40.0%) died of thyroid cancer. The mortality group was characterized by older, mostly male patients who presented with larger initial tumor size compared with survivors.Conclusions: In patients with PTC, the rates of recurrence and cancer mortality were higher in the group with LN metastasis than that in the intra‐thyroid tumor group. J. Surg. Oncol. 2015 111:149–154. © 2015 The Authors. Journal of Surgical Oncology Published by Wiley Periodicals, Inc.
Impact of Deployment‐Related Sexual Stressors on Psychiatric Symptoms After Accounting for Predeployment Stressors: Findings From a U.S. National Guard Cohort
Authors: McCallum Ethan B. , Murdoch Maureen , Erbes Christopher R. , Arbisi Paul , Polusny Melissa A. 
Published: July 2015

AbstractThis study used a longitudinal research design to examine the impact of predeployment stressors and deployment‐related sexual stressors on self‐reported psychiatric symptoms of U.S. National Guard soldiers returning from deployments to Iraq or Afghanistan. Prior to deployment, participants completed measures of depression and posttraumatic stress symptoms, along with an inventory of predeployment stressor experiences. At 3‐months postdeployment, participants (468 men, 60 women) again completed self‐report measures of psychiatric symptoms, along with an inventory of sexual stressors experienced during deployment. We compared a cross‐sectional model of sexual stressors’ impact on psychiatric symptoms, in which only postdeployment reports were considered, to a longitudinal model in which we adjusted for participants’ predeployment stressors and psychiatric symptoms. No participants reported sexual assault during deployment, though sexual harassment was common. The cross‐sectional model suggested that deployment‐related sexual stressors were significantly associated with postdeployment depression (R2 = .11) and posttraumatic stress symptoms (R2 = .10). Once predeployment factors were taken into consideration, however, sexual stressors were no longer significant. The results did not support the notion of lasting negative impact for low‐level sexual stressors (e.g., sexual harassment) during deployment after predeployment stressors are accounted for. Future studies of sexual stressors should consider longitudinal designs.
Homelessness‐Related Traumatic Events and PTSD Among Women Experiencing Episodes of Homelessness in Three U.S. Cities
Authors: Whitbeck Les B. , Armenta Brian E. , Gentzler Kari C. 
Published: July 2015

AbstractIn this article, we report the prevalence of traumatic events (TEs), lifetime and 12‐month posttraumatic stress disorder (PTSD) among 148 women experiencing homelessness in 3 midsized cities in the United States (Omaha, NE, Pittsburgh, PA, and Portland, OR). The women ranged in age from 19 to 54 years with an average age of 38.89 years (SD = 10.18). The sample was 42.6% White/European American. We investigated the mediation of distal TEs (i.e., childhood maltreatment) by more proximal TEs associated with being homeless (i.e., homelessness‐related stressors) for meeting diagnostic criteria for 12‐month PTSD. Results indicated that 42.6% of the women met criteria for lifetime PTSD and 39.7% met criteria for past‐year PTSD. The number of TEs reported ranged from 0 to 16 in order of prevalence with a median of 6 TEs. The correlations between childhood maltreatment and 12‐month PTSD ranged from .16 to .20 and the correlations between homelessness‐related stressors and 12‐month PTSD ranged from .21 to .30. The mediation analysis was consistent with the association between childhood maltreatment and past‐year PTSD being fully mediated by homelessness‐related trauma.
Stable Formation of Gold Nanoparticles onto Redox‐Active Solid Biosubstrates Made of Squid Suckerin Proteins
Authors: Cantaert Bram , Ding Dawei , Rieu Clément , Petrone Luigi , Hoon Shawn , Kock Kian Hong , Miserez Ali 
Published: July 2015

The use of biomolecules to synthesize inorganic nanomaterials, including metallic nanoparticles, offers the ability to induce controlled growth under mild environmental conditions. Here, recently discovered silk‐like “suckerin” proteins are used to induce the formation of gold nanoparticles (AuNPs). Advantage is taken of the distinctive biological and physico‐chemical characteristics of suckerins, namely their facile recombinant expression, their solubility in aqueous solutions, and their modular primary structure with high molar content of redox‐active tyrosine (Tyr) residues to induce the formation of AuNPs not only in solution, but also from nanostructured solid substrates fabricated from suckerins.
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