bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative Hyperbilirubinemia Suggests the Occurrence of Complications After Esophagectomy for Esophageal Cancer
Authors: Takesue Tomoko , Takeuchi Hiroya , Fukuda Kazumasa , Nakamura Rieko , Takahashi Tsunehiro , Wada Norihito , Kawakubo Hirofumi , Saikawa Yoshiro , Omori Tai , Kitagawa Yuko 
Published: January 2015

AbstractBackground
Serum bilirubin levels frequently increase after esophagectomy for esophageal cancer. Several studies have reported hyperbilirubinemia in patients with postoperative complications. We aimed to perform a detailed large‐scale analysis to clarify this association.MethodsWe compared postoperative serum bilirubin levels of 200 patients with esophageal cancer who underwent esophagectomy, with and without postoperative complications, from January 2008 to July 2013 at Keio University Hospital, Tokyo, Japan. We also analyzed other risk factors for postoperative hyperbilirubinemia by univariate and multivariate analyses in an attempt to determine the mechanism of postoperative hyperbilirubinemia.ResultsHyperbilirubinemia (total bilirubin >2.0 mg/dL) occurred in 71 patients (35.5 %). The mean total bilirubin peak level was 1.5 mg/dL in patients without complications, 2.0 mg/dL in those with at least one complication, 2.1 mg/dL in those with pneumonia, and 2.3 mg/dL in those with anastomotic leakage. Bilirubin levels were significantly higher in each complication group than in the non‐complication group (p < 0.05 for all). Risk factors of postoperative hyperbilirubinemia by univariate analysis were the preoperative bilirubin level, video‐assisted thoracoscopic surgery, three‐field lymph node dissection, thoracic duct resection, prolonged surgical duration, severe complications (Clavien–Dindo grade ≥3), and severe anastomotic leakage (Clavien–Dindo grade ≥3). In contrast, the pT factor and postoperative enteral nutrition were negatively associated with postoperative hyperbilirubinemia. Risk factors by multivariate analysis were the preoperative bilirubin level, prolonged surgical duration, severe complications, and postoperative enteral nutrition.ConclusionsAlthough various factors impact postoperative hyperbilirubinemia, postoperative complications were most significantly associated with postoperative hyperbilirubinemia. Patients with postoperative hyperbilirubinemia after esophagectomy must be managed more carefully because unnoticed complications may be associated with hyperbilirubinemia.
Genetic differences in ksdD influence on the ADD/AD ratio of Mycobacterium neoaurum
Authors: Xie Rili , Shen Yanbing , Qin Ning , Wang Yibo , Su Liqiu , Wang Min 
Published: January 2015

Abstract
Mycobacterium neoaurum TCCC 11028 (MNR) and M. neoaurum TCCC 11028 M3 (MNR M3) significantly differ in the ratio of androst-1,4-diene-3,17-dione (ADD) to androst-4-ene-3,17-dione (AD) produced. The large fluctuations are related to the dehydrogenation activity of 3-ketosteroid-Δ1-dehydrogenase (KsdD). Analysis of the primary structure of KsdD showed that the Ser-138 of KsdD-MNR changed to Leu-138 of KsdD-MNR M3 because of C413T in the ksdD gene. This phenomenon directly affected KsdD activity. The effect of the primary structure of KsdD on dehydrogenation activity was confirmed through exogenous expression. Whole-cell transformation initially revealed that KsdD-MNR showed a higher dehydrogenation activity than KsdD-MNR M3. Then, ksdD gene replacement strain was constructed by homologous recombination. The results of steroid transformation experiments showed that the ability of the MNR M3ΔksdD::ksdD-MNR strain to produce ADD was improved and it returned to the similar level of the MNR strain. This result indicated that the ADD/AD ratio of the two M. neoaurum strains was influenced by the difference in ksdD. The mechanism by which residue mutations alter enzyme activity may be connected with the crystal structure of KsdD from Rhodococcus erythropolis SQ1. As a key amino acid residue in the active center position, Ser-138 played an important role in maintaining the active center in the hydrophobic environment of KsdD. This study may serve as a basis for future studies on the structural analysis and catalytic mechanism of dehydrogenase.
Pregnancy Intentions, Maternal Behaviors, and Infant Health: Investigating Relationships With New Measures and Propensity Score Analysis
Authors: Kost Kathryn , Lindberg Laura 
Published: January 2015

AbstractThe premise that unintended childbearing has significant negative effects on the behavior of mothers and on the health of infants strongly influences public health policy and much of current research on reproductive behaviors. Yet, the evidence base presents mixed findings. Using data from the U.S. National Survey of Family Growth, we employ a measure of pregnancy intentions that incorporates the extent of mistiming, as well as the desire scale developed by Santelli et al. (Studies in Family Planning, 40, 87–100, 2009). Second, we examine variation in the characteristics of mothers within intention status groups. Third, we account for the association of mothers’ background characteristics with their pregnancy intentions and with the outcomes by employing propensity score weighting. We find that weighting eliminated statistical significance of many observed associations of intention status with maternal behaviors and birth outcomes, but not all. Mistimed and unwanted births were still less likely to be recognized early in pregnancy than intended ones. Fewer unwanted births received early prenatal care or were breast-fed, and unwanted births were also more likely than intended births to be of low birth weight. Relative to births at the highest level of the desire scale, all other births were significantly less likely to be recognized early in pregnancy and to receive early prenatal care.
Radiologic and Histopathologic Features of Calcifying Pseudoneoplasm of the Neural Axis
Authors: Kocovski Linda , Parasu Naveen , Provias John P. , Popovic Snezana 
Published: January 2015

Aim To describe the radiologic and corresponding histopathologic features of calcifying pseudoneoplasms of the neural axis. Methods Two cases of calcifying pseudoneoplasm of the neural axis were retrospectively reviewed. The first case was documented in a 64-year-old woman, who presented with lower back pain with radiation to her left leg. The second case was documented in a 70-year-old man, who presented with headaches. Medical records, radiologic and histologic findings, and related literature were reviewed. Results In the first case, imaging of the lumbar spine revealed a 3.8 × 2.2-cm calcified lesion at the level of vertebrae L5 and S1. A subsequent excision exposed an extradural lesion at L5. Histopathologic examination showed amorphous and granular calcifying material with occasional fibrohistiocytic and giant cell reaction, consistent with calcifying pseudoneoplasm of the neural axis. In the second case, imaging of the head revealed a 2.4 × 2.6-cm well-circumscribed, lobulated, calcified lesion within the basal frontal lobe. Subsequent resection exposed an intradural mass with a nodular arrangement of amorphous and granular calcifying material associated with fibrohistiocytic and giant cell reaction. Both patients had a favorable postoperative course and failed to show any clinical or radiologic sign of recurrence. Conclusion Calcifying pseudoneoplasm of the neural axis is an uncommon condition with an excellent prognosis but is often misdiagnosed due to its nonspecific clinical presentation and varied findings on radiology.
Is Procalcitonin-Guided Antimicrobial Use Cost-Effective in Adult Patients with Suspected Bacterial Infection and Sepsis?
Authors: Harrison Michelle , Collins Curtis D. 
Published: January 2015

OBJECTIVEProcalcitonin has emerged as a promising biomarker of bacterial infection. Published literature demonstrates that use of procalcitonin testing and an associated treatment pathway reduces duration of antibiotic therapy without impacting mortality. The objective of this study was to determine the financial impact of utilizing a procalcitonin-guided treatment algorithm in hospitalized patients with sepsis.DESIGNCost-minimization and cost-utility analysis.PATIENTSHypothetical cohort of adult ICU patients with suspected bacterial infection and sepsis.METHODSUtilizing published clinical and economic data, a decision analytic model was developed from the U.S. hospital perspective. Effectiveness and utility measures were defined using cost-per-clinical episode and cost per quality-adjusted life years (QALYs). Upper and lower sensitivity ranges were determined for all inputs. Univariate and probabilistic sensitivity analyses assessed the robustness of our model and variables. Incremental cost-effectiveness ratios (ICERs) were calculated and compared to predetermined willingness-to-pay thresholds.RESULTSBase-case results predicted the use of a procalcitonin-guided treatment algorithm dominated standard care with improved quality (0.0002 QALYs) and decreased overall treatment costs ($65). The model was sensitive to a number of key variables that had the potential to impact results, including algorithm adherence (<42.3%), number and cost of procalcitonin tests ordered (≥9 and >$46), days of antimicrobial reduction (<1.6 d), incidence of nephrotoxicity and rate of nephrotoxicity reduction.CONCLUSIONThe combination of procalcitonin testing with an evidence-based treatment algorithm may improve patients’ quality of life while decreasing costs in ICU patients with suspected bacterial infection and sepsis; however, results were highly dependent on a number of variables and assumptions.Infect Control Hosp Epidemiol 2014;00(0): 1–8
The asymptotics of the moving contact line: cracking an old nut
Authors: Sibley David N. , Nold Andreas , Kalliadasis Serafim 
Published: January 2015

AbstractFor contact line motion where the full Stokes flow equations hold, full matched asymptotic solutions using slip models have been obtained for droplet spreading and more general geometries. These solutions to the singular perturbation problem in the slip length, however, all involve matching through an intermediate region that is taken to be separate from the outer–inner regions. Here, we show that the intermediate region is in fact an overlap region representing extensions of both the outer and the inner region, allowing direct matching to proceed. In particular, we investigate in detail how a previously seen result of the matching of the cubes of the free surface slope is justified in the lubrication setting. We also extend this two-region direct matching to the more general Stokes flow case, offering a new perspective on the asymptotics of the moving contact line problem.
Free radially expanding liquid sheet in air: time- and space-resolved measurement of the thickness field
Authors: Vernay C. , Ramos L. , Ligoure C. 
Published: January 2015

AbstractThe collision of a liquid drop against a small target results in the formation of a thin liquid sheet that extends radially until it reaches a maximum diameter. The subsequent retraction is due to the air–liquid surface tension. We have used a time- and space-resolved technique to measure the thickness field of this class of liquid sheet, based on the grey-level measurement of the image of a dyed liquid sheet recorded using a high-speed camera. This method enables a precise measurement of the thickness in the range $10{-}450~{\rm\mu}\text{m}$, with a temporal resolution equal to that of the camera. We have measured the evolution with time since impact, $t$, and radial position, $r$, of the thickness, $h(r,t)$, for various drop volumes and impact velocities. Two asymptotic regimes for the expansion of the sheet are evidenced. The scalings of the thickness with $t$ and $r$ measured in the two regimes are those that were predicted by Rozhkov et al. (Proc. R. Soc. Lond. A, vol. 460, 2004, pp. 2681–2704) for the short-time regime and Villermaux and Bossa (J. Fluid Mech., vol. 668, 2011, pp. 412–435) for the long-time regime, but never experimentally measured before. Interestingly, our experimental data also provide evidence for the existence of a maximum of the film thickness $h_{max}(r)$ at a radial position $r_{h_{max}}(t)$ corresponding to the cross-over of these two asymptotic regimes. The maximum moves with a constant velocity of the order of the drop impact velocity, as expected theoretically. Thanks to our visualization technique, we also provide evidence of an azimuthal thickness modulation of the liquid sheets.
Caffeine increases sugar-sweetened beverage consumption in a free-living population: a randomised controlled trial
Authors: Keast Russell S. J. , Swinburn Boyd A. , Sayompark Dhoungsiri , Whitelock Susie , Riddell Lynn J. 
Published: January 2015

Excessive sugar-sweetened beverage (SSB) consumption has been associated with overweight and obesity. Caffeine is a common additive to SSB, and through dependence effects, it has the potential to promote the consumption of caffeine-containing foods. The objective of the present study was to assess the influence that caffeine has on the consumption of SSB. Participants (n99) were blindly assigned to either a caffeinated SSB (C-SSB) or a non-caffeinated SSB (NC-SSB) group. Following randomisation, all participants completed a 9 d flavour-conditioning paradigm. They then completed a 28 dad libitumintake intervention where they consumed as much or as little of C-SSB or NC-SSB as desired. The amount consumed (ml) was recorded daily, 4 d diet diaries were collected and liking of SSB was assessed at the start and end of the intervention. Participants (n50) consuming the C-SSB had a daily SSB intake of 419 (sd298) ml (785 (sd559) kJ/d) over the 28 d intervention, significantly more than participants (n49) consuming the NC-SSB (273 (sd278) ml/d, 512 (sd521) kJ/d) (P< 0·001). A trained flavour panel (n30) found no difference in flavour between the C-SSB and NC-SSB (P>0·05). However, participants who consumed the C-SSB liked the SSB more than those who consumed the NC-SSB (6·3v.6·0 on a nine-point hedonic scale,P= 0·022). The addition of low concentrations of caffeine to the SSB significantly increases the consumption of the SSB. Regulating caffeine as a food additive may be an effective strategy to decrease the consumption of nutrient-poor high-energy foods and beverages.
Measuring the economic impact of improved control of sub-clinical mastitis in Irish dairy herds
Authors: DILLON E. J. , HENNESSY T. , CULLINAN J. 
Published: January 2015

SUMMARYImprovements in milk quality are important if the Irish dairy industry is to grow sustainably and retain a competitive advantage in a post-quota environment. In this regard, superior animal health has an important role to play. In order to reduce the costs of disease and to improve best practice it is important to demonstrate the economic gains achievable from improved dairy herd health. Elevated levels of somatic cell count (SCC) are an indicator of the prevalence of clinical and sub-clinical mastitis in dairy herds. Nationally representative farm-level data for Ireland (2008–2011) and panel data methods are used here to consider the independent effect of herd-level SCC (an annual weighted average figure based on monthly milk bulk tank readings) on both milk yield and gross margin per cow. Results indicate a 2% reduction in productivity for farms with SCC above 400 (‘000 cells/ml), while a reduction in bulk tank SCC from 400 to 300 (‘000 cells/ml) for the average herd (55 cows) results in an annual increase in gross margin of €1045. The impact of a range of herd management practices on SCC is also considered, with such practices shown to be important in influencing animal health.
Phonation takes precedence over articulation in development as well as evolution of language
Authors: Oller D. Kimbrough 
Published: January 2015

AbstractEarly human vocal development is characterized first by emerging control of phonation and later by prosodic and supraglottal articulation. The target article has missed the opportunity to use these facts in the characterization of evolution in language-specific brain mechanisms. Phonation appears to be the initial human-specific brain change for language, and it was presumably a key target of selection in early hominin evolution.
Collateral benefits from public and private conservation lands: a comparison of ecosystem service capacities
Authors: VILLAMAGNA A. , SCOTT L. , GILLESPIE J. 
Published: January 2015

SUMMARYProtected areas remain the most commonly used tool forin situconservation; however growth in the USA's system of public lands has stagnated while private land conservation continues to expand. Easements can provide a range of ecosystem services (ESs), but it is unknown whether conservation easements maintain ES capacities equivalent to public protected areas. Evaluation of the capacity of seven ESs on federal and state protected areas and conservation easements in the USA using spatially-explicit ES models and publicly available data indicated that ES capacities in easements were equal to or greater than capacities within state or federal protected areas for six of seven services and, when bundled together, conservation easements protected greater focal ES capacity than other conservation areas. Economic incentive programmes and regulatory mechanisms may be used to stimulate capacity improvements for surface water regulation, riparian filtration, erosion control, and carbon storage on conservation easements, and landscape-level conservation efforts should (1) continue to protect natural and uninhabited areas that provide ecosystem and biological diversity, (2) expand private conservation efforts close to human population centres, and (3) limit future development to areas with high regulating service capacity that can sustain new population growth.
A hand hygiene intervention to reduce infections in child daycare: a randomized controlled trial
Authors: ZOMER T. P. , ERASMUS V. , LOOMAN C. W. , TJON-A-TSIEN A. , VAN BEECK E. F. , DE GRAAF J. M. , VAN BEECK A. H. E. , RICHARDUS J. H. , VOETEN H. A. C. M. 
Published: January 2015

SUMMARYInfections are common in children attending daycare centres (DCCs). We evaluated the effect of a hand hygiene (HH) intervention for caregivers on the incidence of gastrointestinal and respiratory infections in children. The intervention was evaluated in a two-arm cluster randomized controlled trial. Thirty-six DCCs received the intervention including HH products, training sessions, and posters/stickers. Thirty-five control DCCs continued usual practice. Incidence of episodes of diarrhoea and the common cold in children was monitored by parents during 6 months. Using multilevel Poisson regression, incidence rate ratios (IRRs) with 95% confidence intervals (CIs) were obtained. Diarrhoeal incidence was monitored in 545 children for 91 937 days. During follow-up, the incidence was 3·0 episodes per child-year in intervention DCCsvs.3·4 in control DCCs (IRR 0·90, 95% CI 0·73–1·11). Incidence of the common cold was monitored in 541 children for 91 373 days. During follow-up, the incidence was 8·2 episodes per child-year in intervention DCCsvs.7·4 in control DCCs (IRR 1·07, 95% CI 0·97–1·19). In this study, no evidence for an effect of the intervention was demonstrated on the incidence of episodes of diarrhoea and the common cold.
Culturally adapted cognitive behaviour therapy for Māori with major depression
Authors: Bennett Simon T. , Flett Ross A. , Babbage Duncan R. 
Published: January 2015

AbstractMāori are the indigenous people of New Zealand and in 2006 comprised approximately 15% of the country's population. Epidemiological data suggests Māori experience rates of depression that are higher than the general population and are less likely to engage in treatment for mental health issues. The main aim of this study was to evaluate the effectiveness of an adapted approach to psychotherapy with Māori. The broad goals of which were to provide empirically grounded guidance for therapists aspiring to provide best practice to their Māori clients. This paper documents the evaluation of a cognitive behavioural therapy (CBT) treatment protocol specifically designed and adapted for delivery to adult Māori clients with a diagnosis of depression. The treatment protocol was administered to 16 Māori clients with a primary diagnosis of depression. The adapted treatment incorporated Māori processes for engagement, spirituality, family involvement and metaphor. The intervention exhibited considerable promise with large significant reductions in depressive symptomatology in the participant group. Furthermore, significant reductions in negative cognition were observed. This is the first piece of applied clinical research that has examined the effectiveness of an individual psychological therapy exclusively with Māori and the first to examine individual psychotherapy outcomes with an indigenous population using an effectiveness study. The findings have a number of implications for the treatment of Māori clients with depression. This study provides useful guidelines for clinicians providing psychological treatment to Māori and provides strong support for the cultural adaptation of psychological treatment with ethnic minority groups.
Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p
Authors: Ma M-Z , Chu B-F , Zhang Y , Weng M-Z , Qin Y-Y , Gong W , Quan Z-W 
Published: January 2015

AbstractProtein-coding genes account for only ~2% of the human genome, whereas the vast majority of transcripts are non-coding RNAs (ncRNAs) including long ncRNAs (lncRNAs). A growing volume of literature has proposed that lncRNAs are important factors in cancer. Colon cancer-associated transcript-1 (CCAT1), an lncRNA, which was first identified in colon cancer, was previously shown to promote tumor development and be a negative prognostic factor in gastric cancer. However, the mechanism through which CCAT1 exerts its oncogenic activity remains largely unknown. Recently, a novel regulatory mechanism has been proposed in which RNAs can cross-talk with each other via competing shared for microRNAs (miRNAs). The proposed competitive endogenous RNAs could mediate the bioavailability of miRNAs on their targets, thus imposing another level of posttranscriptional regulation. In this study, we demonstrated that CCAT1 was upregulated in gallbladder cancer (GBC) tissues. CCAT1 silencing downregulated, whereas CCAT1 overexpression enhanced the expression of miRNA-218-5p target gene Bmi1 through competitively ‘spongeing’ miRNA-218-5p. Our data revealed that CCAT1 knockdown impaired the proliferation and invasiveness of GBC cells, at least in part through affecting miRNA-218-5p-mediated regulation of Bmi1. Moreover, CCAT1 transcript level was correlated with Bmi1 mRNA level in GBC tissues. Together, these results suggest that CCAT1 is a driver of malignancy, which acts in part through ‘spongeing’ miRNA-218-5p.