bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why Do Model Tropical Cyclones Intensify More Rapidly at Low Latitudes?
Authors: Smith Roger K. , Kilroy Gerard , Montgomery Michael T. 
Published: October 2014

Abstract
The authors examine the problem of why model tropical cyclones intensify more rapidly at low latitudes. The answer to this question touches on practically all facets of the dynamics and thermodynamics of tropical cyclones. The answer invokes the conventional spin-up mechanism, as articulated in classical and recent work, together with a boundary layer feedback mechanism linking the strength of the boundary layer inflow to that of the diabatic forcing of the meridional overturning circulation.
The specific role of the frictional boundary layer in regulating the dependence of the intensification rate on latitude is discussed. It is shown that, even if the tangential wind profile at the top of the boundary layer is held fixed, a simple, steady boundary layer model produces stronger low-level inflow and stronger, more confined ascent out of the boundary layer as the latitude is decreased, similar to the behavior found in a time-dependent, three-dimensional numerical model. In an azimuthally averaged view of the problem, the most prominent quantitative differences between the time-dependent simulations at 10° and 30°N are the stronger boundary layer inflow and the stronger ascent of air exiting the boundary layer, together with the much larger diabatic heating rate and its radial gradient above the boundary layer at the lower latitude. These differences, in conjunction with the convectively induced convergence of absolute angular momentum, greatly surpass the effects of rotational stiffness (inertial stability) and evaporative-wind feedback that have been proposed in some prior explanations.
Tropical Cyclones in the UPSCALE Ensemble of High-Resolution Global Climate Models*
Authors: Roberts Malcolm J. , Vidale Pier Luigi , Mizielinski Matthew S. , Demory Marie-Estelle , Schiemann Reinhard , Strachan Jane , Hodges Kevin , Bell Ray , Camp Joanne 
Published: October 2014

Abstract
The U.K. on Partnership for Advanced Computing in Europe (PRACE) Weather-Resolving Simulations of Climate for Global Environmental Risk (UPSCALE) project, using PRACE resources, constructed and ran an ensemble of atmosphere-only global climate model simulations, using the Met Office Unified Model Global Atmosphere 3 (GA3) configuration. Each simulation is 27 years in length for both the present climate and an end-of-century future climate, at resolutions of N96 (130 km), N216 (60 km), and N512 (25 km), in order to study the impact of model resolution on high-impact climate features such as tropical cyclones. Increased model resolution is found to improve the simulated frequency of explicitly tracked tropical cyclones, and correlations of interannual variability in the North Atlantic and northwestern Pacific lie between 0.6 and 0.75. Improvements in the deficit of genesis in the eastern North Atlantic as resolution increases appear to be related to the representation of African easterly waves and the African easterly jet. However, the intensity of the modeled tropical cyclones as measured by 10-m wind speed remains weak, and there is no indication of convergence over this range of resolutions. In the future climate ensemble, there is a reduction of 50% in the frequency of Southern Hemisphere tropical cyclones, whereas in the Northern Hemisphere there is a reduction in the North Atlantic and a shift in the Pacific with peak intensities becoming more common in the central Pacific. There is also a change in tropical cyclone intensities, with the future climate having fewer weak storms and proportionally more strong storms.
Monitoring Agricultural Risk in Canada Using L-Band Passive Microwave Soil Moisture from SMOS
Authors: Champagne Catherine , Davidson Andrew , Cherneski Patrick , L’Heureux Jessika , Hadwen Trevor 
Published: October 2014

Abstract
Soil moisture from Soil Moisture Ocean Salinity (SMOS) passive microwave satellite data was assessed as an information source for identifying regions experiencing climate-related agricultural risk for a period from 2010 to 2013. Both absolute soil moisture and soil moisture anomalies compared to a 4-yr SMOS satellite baseline were used in the assessment. The 4-yr operational period of SMOS was wetter than the 30-yr climate normal in many locations, particularly in the late summer for most regions and in the spring for the province of Manitoba. This leads to a somewhat unrepresentative baseline that skews anomaly measures at different parts of the growing season. SMOS soil moisture does, however, show a clear trend where extremes are present, with drier-than-average conditions during periods that drought and dry soil risks were identified and wetter-than-average conditions when flooding and excess moisture were present. Areas where extreme weather events caused crop losses were identifiable using SMOS soil moisture, both at the provincial and regional scales. The variability in soil moisture between at-risk areas and normal areas is very small but consistent, both geographically and over time, making SMOS a good real-time indicator for risk assessment.
Ensemble Kalman Filter Assimilation of HIWRAP Observations of Hurricane Karl (2010) from the Unmanned Global Hawk Aircraft
Authors: Sippel Jason A. , Zhang Fuqing , Weng Yonghui , Tian Lin , Heymsfield Gerald M. , Braun Scott A. 
Published: October 2014

Abstract
This study utilizes an ensemble Kalman filter (EnKF) to assess the impact of assimilating observations of Hurricane Karl from the High-Altitude Imaging Wind and Rain Airborne Profiler (HIWRAP). HIWRAP is a new Doppler radar on board the NASA Global Hawk unmanned airborne system, which has the benefit of a 24–26-h flight duration, or about 2–3 times that of a conventional aircraft. The first HIWRAP observations were taken during NASA’s Genesis and Rapid Intensification Processes (GRIP) experiment in 2010. Observations considered here are Doppler velocity (Vr) and Doppler-derived velocity–azimuth display (VAD) wind profiles (VWPs). Karl is the only hurricane to date for which HIWRAP data are available. Assimilation of either Vr or VWPs has a significant positive impact on the EnKF analyses and forecasts of Hurricane Karl. Analyses are able to accurately estimate Karl’s observed location, maximum intensity, size, precipitation distribution, and vertical structure. In addition, forecasts initialized from the EnKF analyses are much more accurate than a forecast without assimilation. The forecasts initialized from VWP-assimilating analyses perform slightly better than those initialized from Vr-assimilating analyses, and the latter are less accurate than EnKF-initialized forecasts from a recent proof-of-concept study with simulated data. Likely causes for this discrepancy include the quality and coverage of the HIWRAP data collected from Karl and the presence of model error in this real-data situation. The advantages of assimilating VWP data likely include the ability to simultaneously constrain both components of the horizontal wind and to circumvent reliance upon vertical velocity error covariance.
Representation of the Subgrid-Scale Turbulent Transport in Convective Boundary Layers at Gray-Zone Resolutions
Authors: Shin Hyeyum Hailey , Hong Song-You 
Published: October 2014

Abstract
Parameterization of the unresolved vertical transport in the planetary boundary layer (PBL) is one of the key physics algorithms in atmospheric models. This study attempts to represent the subgrid-scale (SGS) turbulent transport in convective boundary layers (CBLs) at gray-zone resolutions by investigating the effects of grid-size dependency in the vertical heat transport parameterization for CBL simulations. The SGS transport profile is parameterized based on the 2013 conceptual derivation by Shin and Hong. First, nonlocal transport via strong updrafts and local transport via the remaining small-scale eddies are separately calculated. Second, the SGS nonlocal transport is formulated by multiplying a grid-size dependency function with the total nonlocal transport profile fit to the large-eddy simulation (LES) output. Finally, the SGS local transport is formulated by multiplying a grid-size dependency function with the total local transport profile, which is calculated using an eddy-diffusivity formula. The new algorithm is evaluated against the LES output and compared with a conventional nonlocal PBL parameterization.
For ideal CBL cases, by considering the scale dependency in the parameterized vertical heat transport, improvements over the conventional nonlocal K-profile model appear in mean profiles, resolved and SGS vertical transport profiles with their grid-size dependency, and the energy spectrum. Real-case simulations for convective rolls show that the simulated roll structures are more robust with stronger intensity when the new algorithm is used.
Risk Factors for Short-term Adverse Events and Readmission After Arthroscopic Meniscectomy
Authors: Basques Bryce A. , Gardner Elizabeth C. , Varthi Arya G. , Fu Michael C. , Bohl Daniel D. , Golinvaux Nicholas S. , Grauer Jonathan N. 
Published: October 2014

Background: Recent studies have questioned the efficacy of meniscectomy in older patients with and without evidence of osteoarthritis; however, it continues to be frequently performed. There is limited information about age and other risk factors for adverse events and readmission after the procedure. This knowledge is vital to understand the true risk profile of this common surgery. Purpose: To investigate if age and medical comorbidities were risk factors for postoperative adverse events and readmission after meniscectomy. Study Design: Case-control study; Level of evidence, 3. Methods: Patients who underwent arthroscopic meniscectomy between 2005 and 2012 were identified from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database. Age ≥65 years and medical comorbidities were evaluated as risk factors for any adverse event (AAE), severe adverse events (SAEs), and readmission after meniscectomy using univariate and multivariate analyses. Results: A total of 17,774 patients who underwent meniscectomy were identified. The mean age was 53.0 ± 13.6 years. A total of 3420 patients (19.2%) were ≥65 years. Overall, 208 patients (1.17%) had AAE, 203 patients (1.14%) had an SAE, and 102 patients were readmitted (0.97%). Multivariate logistic regression analyses demonstrated no significant differences between age groups for the occurrence of AAE, SAEs, and readmission. Patients with American Society of Anesthesiologists classification ≥3 had increased odds of AAE (odds ratio [OR], 1.58), SAEs (OR, 1.59), and readmission (OR, 1.99). Patients with diabetes had increased odds of AAE (OR, 1.57) and SAEs (OR, 1.51). Smokers had increased odds of readmission (OR, 1.67). Patients with pulmonary disease had increased odds of AAE (OR, 1.76) and SAEs (OR, 1.70). Conclusion: Meniscectomy is a safe procedure in older patients, as age over 65 years did not increase the odds of any of the adverse events studied. However, regardless of age, patients with an increased comorbidity burden and those with a history of smoking are at increased risk of adverse events and/or readmission after the procedure. Clinical Relevance: Knowledge of these risk factors for adverse events and readmission provides essential information for patient selection and preoperative counseling.
‘Conversion of the Barbarians’ [Huahu ] Discourse as Proto Han Nationalism
Authors: Raz Gil 
Published: October 2014

In the early medieval period, many Chinese viewed the growing popularity of Buddhism, and the rapid integration of Buddhism into Chinese religious life, as a challenge to their own civilisation. A major aspect of the resistance to the growing dominance of Buddhism was a discourse known as the ‘conversion of the barbarians’. This basic narrative of this discourse claimed that Laozi had journeyed west to India where he either became the Buddha or taught the Buddha. This discourse, which was elaborated in several Daoist texts into complex cosmological and mytho-historical narratives thus asserted the primacy of Daoism and relegated Buddhism to a secondary teaching, inferior to Daoism, suitable for ‘barbarians’ but not for Chinese.  This article discusses the development of this discourse, focusing on texts written by Daoists during the fifth century when this discourse was particularly vehement. In this article I will show that this discourse was not merely resistant to Buddhism, but was also critical of various Daoist groups that had accepted Buddhist ideas and practices. Significantly, this discourse associated Daoism with the essence of Chinese civilisation, rather than as a distinct teaching.
Comparison of Salivary and Serum Glucose Levels in Diabetic Patients
Authors: Gupta Shruti , Sandhu Simarpreet Virk , Bansal Himanta , Sharma Deepti 
Published: October 2014

Background: Diabetes mellitus is a noncommunicable disease with a rising prevalence worldwide and in developing countries. The most commonly used diagnostic biofluid for detection of glucose levels is blood, but sample collection is an invasive and painful procedure. Thus, there arises a need for a noninvasive and painless technique to detect glucose levels. Aims and Objectives: The objectives of the present study were to estimate the glucose levels of saliva, to assess if any significant correlation existed between the serum and salivary glucose levels, and to correlate salivary glucose levels with regard to duration of diabetes, age, and gender. In the present study, serum and salivary glucose levels of 200 subjects (100 diabetic subjects and 100 nondiabetic subjects) were estimated by glucose oxidase method. Glycosylated hemoglobin levels were also measured in randomly selected 40 diabetic subjects. Results: The findings of present study revealed a significant correlation between salivary and serum glucose levels in both diabetic and nondiabetic subjects. No significant relationship was observed between salivary glucose levels and gender or age in both diabetics and nondiabetics and between salivary glucose levels and duration of diabetes in diabetics. Conclusion: On the basis of the findings, it was concluded that salivary glucose levels could serve as a potentially noninvasive adjunct to monitor glycemic control in diabetic patients.
GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis
Authors: Dietrich Philipp A. , Yang Chen , Leung Halina H. L. , Lynch Jennifer R. , Gonzales Estrella , Liu Bing , Haber Michelle , Norris Murray D. , Wang Jianlong , Wang Jenny Yingzi 
Published: October 2014

Key Points
GPR84 simultaneously augments β-catenin signaling and an oncogenic transcription program essential for establishment of MLL. Our study demonstrates a strong dependence of hematopoietic stem cell–derived MLL leukemic cells on GPR84 for disease maintenance in vivo.
OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells
Authors: Liu Ta-Ming , Ling Yonghua , Woyach Jennifer A. , Beckwith Kyle , Yeh Yuh-Ying , Hertlein Erin , Zhang Xiaoli , Lehman Amy , Awan Farrukh , Jones Jeffrey A. , Andritsos Leslie A. , Maddocks Kami , MacMurray Jessica , Salunke Santosh B. , Chen Ching-Shih , Phelps Mitch A. , Byrd John C. , Johnson Amy J. 
Published: October 2014

Key Points
OSU-T315 impedes AKT localization in lipid rafts. OSU-T315 shows in vitro and in vivo therapeutic effects.
Cell-type–specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency
Authors: Costa Joana R. , Caputo Valentina S. , Makarona Kalliopi , Layton D. Mark , Roberts Irene A. G. , Almeida Antonio M. , Karadimitris Anastasios 
Published: October 2014

Key Points
B cells but not red cells are GPI deficient in PIGM-associated IGD, caused by a core promoter mutation that abrogates Sp1 binding. In red but not B cells, PIGM transcription is independent of Sp1 binding to the core promoter, hence GPI expression in red cells is near normal.
Single-step assembly of polymer-lipid hybrid nanoparticles for mitomycin C delivery
Authors: Yi Yunfeng , Li Yang , Wu Hongjie , Jia Mengmeng , Yang Xiangrui , Wei Heng , Lin Jinyan , Wu Shichao , Huang Yu , Hou Zhenqing , Xie Liya 
Published: October 2014

Abstract
Mitomycin C is one of the most effective chemotherapeutic agents for a wide spectrum of cancers, but its clinical use is still hindered by the mitomycin C (MMC) delivery systems. In this study, the MMC-loaded polymer-lipid hybrid nanoparticles (NPs) were prepared by a single-step assembly (ACS Nano 2012, 6:4955 to 4965) of MMC-soybean phosphatidyhlcholine (SPC) complex (Mol. Pharmaceutics 2013, 10:90 to 101) and biodegradable polylactic acid (PLA) polymers for intravenous MMC delivery. The advantage of the MMC-SPC complex on the polymer-lipid hybrid NPs was that MMC-SPC was used as a structural element to offer the integrity of the hybrid NPs, served as a drug preparation to increase the effectiveness and safety and control the release of MMC, and acted as an emulsifier to facilitate and stabilize the formation. Compared to the PLA NPs/MMC, the PLA NPs/MMC-SPC showed a significant accumulation of MMC in the nuclei as the action site of MMC. The PLA NPs/MMC-SPC also exhibited a significantly higher anticancer effect compared to the PLA NPs/MMC or free MMC injection in vitro and in vivo. These results suggested that the MMC-loaded polymer-lipid hybrid NPs might be useful and efficient drug delivery systems for widening the therapeutic window of MMC and bringing the clinical use of MMC one step closer to reality.
Lysine suppresses myofibrillar protein degradation by regulating the autophagic-lysosomal system through phosphorylation of Akt in C2C12 cells
Authors: Sato Tomonori , Ito Yoshiaki , Nagasawa Takashi 
Published: October 2014

Abstract
The prevention of muscle wasting is important for maintaining quality of life, since loss of muscle mass can lead to a bedridden state and decreased resistance to diseases. The prevention of muscle wasting requires an increase in protein synthesis and a decrease in protein degradation in skeletal muscle. We previously showed that lysine (Lys) markedly suppressed myofibrillar protein degradation by inhibiting the autophagic-lysosomal system via the mammalian target of rapamycin (mTOR) and other signal molecules in C2C12 cells. In this study, we investigated the involvement of Akt and adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK), two regulators of autophagy, on the suppressive effects of Lys on myofibrillar protein degradation in C2C12 cells. Lys induced the phosphorylation of Akt, but the suppressive effects of Lys on myofibrillar protein degradation and autophagy were completely abolished in the presence of Akt1/2 kinase inhibitor (Akti). Lys suppressed the phosphorylation of AMPK, but this effect was also abolished by Akti. On the other hand, AMPK activation by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside (AICAR) did not affect either Akt activity or the autophagic-lysosomal system in C2C12 cells treated with Lys. These results indicate that regulation of AMPK activity is not essential for the regulation of autophagy by Lys. Taken together, our results show that Lys suppresses myofibrillar protein degradation by the autophagic-lysosomal system through the phosphorylation of Akt in C2C12 cells.
OncoCis: annotation of cis-regulatory mutations in cancer
Authors: Perera Dilmi , Chacon Diego , Thoms Julie AI , Poulos Rebecca C , Shlien Adam , Beck Dominik , Campbell Peter J , Pimanda John E , Wong Jason WH 
Published: October 2014

AbstractWhole genome sequencing has enabled the identification of thousands of somatic mutations within non-coding genomic regions of individual cancer samples. However, identification of mutations that potentially alter gene regulation remains a major challenge. Here we present OncoCis, a new method that enables identification of potential cis-regulatory mutations using cell type-specific genome and epigenome-wide datasets along with matching gene expression data. We demonstrate that the use of cell type-specific information and gene expression can significantly reduce the number of candidate cis-regulatory mutations compared with existing tools designed for the annotation of cis-regulatory SNPs. The OncoCis webserver is freely accessible at https://powcs.med.unsw.edu.au/OncoCis/.
Nailfold videocapillaroscopy micro-haemorrhage and giant capillary counting as an accurate approach for a steady state definition of disease activity in systemic sclerosis
Authors: Sambataro Domenico , Sambataro Gianluca , Zaccara Eleonora , Maglione Wanda , Polosa Riccardo , Afeltra Antonella MV , Vitali Claudio , Del Papa Nicoletta 
Published: October 2014

Abstract
Introduction
Nailfold videocapillaroscopy (NVC) in systemic sclerosis (SSc) is a procedure commonly used for patient classification and subsetting, but not to define disease activity (DA). This study aimed to evaluate whether the number of micro-haemorrhages (MHE), micro-thrombosis (MT), giant capillaries (GC), and normal/dilated capillaries (Cs) in NVC could predict DA in SSc.

Methods
Eight-finger NVC was performed in 107 patients with SSc, and the total number of MHE/MT, GC, and the mean number of Cs were counted and defined as number of micro-haemorrhages (NEMO), GC and Cs scores, respectively. The European Scleroderma Study Group (ESSG) index constituted the gold standard for DA assessment, and scores ≥3.5 and =3 were considered indicative of high and moderate activity, respectively.

Results
NEMO and GC scores were positively correlated with ESSG index (R = 0.65, P <0.0001, and R = 0.47, P <0.0001, respectively), whilst Cs score showed a negative correlation with that DA index (R = -0.30, P <0.001). The area under the curve (AUC) of receiver operating characteristic plots, obtained by NEMO score sensitivity and specificity values in classifying patients with ESSG index ≥3.5, was significantly higher than the corresponding AUC derived from either GC or Cs scores (P <0.03 and P <0.0006, respectively). A modified score, defined by the presence of a given number of MHE/MT and GC, had a good performance in classifying active patients (ESSG index ≥3, sensitivity 95.1%, specificity 84.8%, accuracy 88.7%).

Conclusions
MHE/MT and GC appear to be good indicators of DA in SSc, and enhances the role of NVC as an easy technique to identify active patients.