bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internet health seeking behaviour of parents attending a general paediatric outpatient clinic: A cross-sectional observational study
Authors: Sebelefsky Christian , Karner Denise , Voitl Jasmin , Klein Frederic , Voitl Peter , Böck Andreas 
Published: May 2015

Introduction Our aim was to examine the internet health seeking behaviour of parents attending a general paediatric outpatient clinic. For this purpose, the proportion of parents going online to obtain child health information, the most commonly used online resources, and factors having an influence on internet usage were identified. Methods This cross-sectional observational study was conducted at a general paediatric outpatient clinic in Vienna, Austria. Data collection was done by means of an anonymous questionnaire containing 14 items. A total number of 500 questionnaires were collected. Results Among parents visiting the outpatient clinic, 94.4% use the internet to obtain child health information in general and 21% to be informed about the reason for consultation. Most commonly used online resources are Google (91.4%), websites run by doctors (84.8%), Wikipedia (84.7%), health portals (76.4%), the outpatient clinic's homepage (76.4%), as well as health forums and communities (61.9%). Younger parents ( p = 0.022) and parents of younger children ( p < 0.01) display a higher tendency to use the internet for child health information purposes. Mothers and fathers ( p = 0.151) as well as parents with different completed educational levels (mothers: p = 0.078; fathers: p = 0.388) do not differ in this behaviour. Discussion Important reasons for high internet use might be the inexperience of young parents regarding child health as well as the frequent infections, vaccinations, and preventive check-ups which are associated with young age of children. In contrast to former findings relating to health seekers in general, internet usage of parents is independent of their sex and educational level.
Assessing the impact of telestration on surgical telementoring: A randomized controlled trial
Authors: Budrionis Andrius , Hasvold Per , Hartvigsen Gunnar , Bellika Johan Gustav 
Published: May 2015

Introduction Using graphical annotations in surgical telementoring promises vast improvements in both clinical and educational outcomes. However, these assumptions do not consider the potential patient safety risks resulting from this feature. Major differences in regulations regarding the implementation of telestration encourage an assessment of the utility of this feature on the outcomes of telementoring sessions. Methods Eight students participated in a randomized controlled trial, comparing verbal with annotation-supplemented telementoring via video conferencing. A remote mentor guided the participants through four localization exercises, identifying the features in a still laparoscopic surgery scene using a laparoscopic simulator. Clinical and educational outcomes were assessed; the time consumption and quality of mentoring were determined. Results The study revealed no significant difference in localizing the intervention between the studied methods, while educational outcomes favoured verbal mentoring. Telestration-supplemented guidance was considerably faster and resulted in fewer miscommunications between the mentor and mentee. Discussion The initial hypothesis of the major clinical and education benefits of telestration in telementoring was not supported. A potential 33% decrease in the duration of the mentored episodes is expected due to the ability to annotate live video content. However, the impact of time saving on the outcome of the procedure remains unclear. Regardless of the quantitative measures, most of the participants and the mentor agreed that graphical annotations provide advantages over verbal guidance.
Treating rural paediatric obesity through telemedicine vs. telephone: Outcomes from a cluster randomized controlled trial
Authors: Davis Ann M , Sampilo Marilyn , Gallagher Katherine Steiger , Dean Kelsey , Saroja M Baby , Yu Qing , He Jianghua , Sporn Nora 
Published: May 2015

Objective The objective of the current study was to examine the feasibility of telemedicine vs. telephone for the delivery of a multidisciplinary weekly family-based behavioural group intervention to treat paediatric obesity delivered to families living in rural areas using a randomized controlled trial methodology. Methods 103 rural children and their families were recruited. Feasibility measures included participant satisfaction, session attendance and retention. Treatment outcome measures included child Body Mass Index z-score (BMIz), parent BMI, 24-hour dietary recalls, accelerometer data, the child behavior checklist and the behavioral pediatrics feeding assessment scale. Results Participants were highly satisfied with the intervention both via telemedicine and via telephone. Completion rates were much higher than for other paediatric obesity intervention programmes, and both methodologies were highly feasible. There were no differences in telemedicine and telephone groups on primary outcomes. Conclusion Both telemedicine and telephone intervention appear to be feasible and acceptable methods of delivering paediatric obesity treatment to rural children.
Benefits of being bilingual? The relationship between pupils’ perceptions of teachers’ appreciation of their home language and executive functioning
Authors: Goriot Claire , Denessen Eddie , Bakker Joep , Droop Mienke 
Published: May 2015

Aims: We aimed to investigate whether bilingual pupil’s perceptions of teachers’ appreciation of their home language were of influence on bilingual cognitive advantages. Design: We examined whether Dutch bilingual primary school pupils who speak either German or Turkish at home differed in perceptions of their teacher’s appreciation of their HL, and whether these differences could explain differences between the two groups in executive functioning. Data and analysis: Executive functioning was measured through computer tasks, and perceived home language appreciation through orally administered questionnaires. The relationship between the two was assessed with regression analyses. Findings: German-Dutch pupils perceived there to be more appreciation of their home language from their teacher than Turkish-Dutch pupils. This difference did partly explain differences in executive functioning. Besides, we replicated bilingual advantages in nonverbal working memory and switching, but not in verbal working memory or inhibition. Originality and significance: This study demonstrates that bilingual advantages cannot be dissociated from the influence of the sociolinguistic context of the classroom. Thereby, it stresses the importance of culturally responsive teaching.
Aneurysmal vasculopathy in human-acquired immunodeficiency virus-infected adults: Imaging case series and review of the literature
Authors: Thawani Jayesh P , Nayak Nikhil R , Pisapia Jared M , Petrov Dmitriy , Pukenas Bryan A , Hurst Robert W , Smith Michelle J 
Published: May 2015

Background Intracranial vasculopathy in adult patients with human-acquired immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a rare but increasingly recognized disease entity. Objective We aimed to contribute to and summarize the adult literature describing patients with HIV/AIDS who have intracranial vasculopathy. Methods A retrospective review of adult patients with HIV/AIDS undergoing diagnostic cerebral angiography at our institution from 2007–2013 was performed. A literature review of relevant existing studies was performed. Results Five adult patients with HIV-related aneurysmal and occlusive vasculopathy were diagnosed and/or treated at our institution. A comprehensive review of the literature yielded data from 17 series describing 28 adult patients with HIV/AIDS and intracranial vasculopathy. Our review suggests that low CD4 count, motor weakness, and meningismus may be associated with the sequelae of intracranial vasculopathy/vasculitis in patients with HIV/AIDS. Conclusion Patients with HIV/AIDS who have aneurysmal and stenotic vascular disease may benefit from earlier surveillance with the onset of neurological symptoms. The roles of medical, open surgical, and endovascular therapy in this unique entity will be further defined as the pathological basis of the disease is better understood.
Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells
Authors: Lu Min , Xia Lijuan , Liu Yen-Chun , Hochman Tsivia , Bizzari Laetizia , Aruch Daniel , Lew Jane , Weinberg Rona , Goldberg Judith D. , Hoffman Ronald 
Published: May 2015

Key PointsLCN2 acts to generate reactive oxygen species, leading to increased DNA strand breaks and apoptosis in normal CD34+ cells. LCN2 promotes the generation of osteoblasts but diminishes adipogenesis, resembling the composition of the MF marrow microenvironment.
High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens
Authors: Wegner Julia , Hackenberg Stephan , Scholz Claus-Jürgen , Chuvpilo Sergey , Tyrsin Dmitry , Matskevich Alexey A. , Grigoleit Götz Ulrich , Stevanović Stefan , Hünig Thomas 
Published: May 2015

Key Points
CD8 memory T cells in PBMCs are antigen-hyporesponsive due to loss of priming by tissue-dependent interactions. Preculture at high cell density allows the detection of antiviral and antitumor responses that may be overlooked without this step.
Smoke-free legislation and childhood hospitalisations for respiratory tract infections
Authors: Been Jasper V. , Millett Christopher , Lee John Tayu , van Schayck Constant P. , Sheikh Aziz 
Published: May 2015

Second-hand smoke exposure is a major risk factor for respiratory tract infections (RTIs). Although evidence suggests important early-life health benefits of smoke-free public environments, the impact on childhood RTIs is unclear. We investigated the association between England's smoke-free legislation and childhood RTI hospitalisations.We used the Hospital Episode Statistics database to obtain nationwide data on hospital admissions for acute RTIs among children (<15 years of age) from 2001 to 2012. Hospitalisation counts were disaggregated by month, age group, sex and small-area level, and linked to urbanisation, region, deprivation index and corresponding population estimates. Negative binomial regression analyses were adjusted for confounders, seasonal variation, temporal autocorrelation, population-size changes and underlying incidence trends. Models allowed for sudden and gradual changes following the smoke-free legislation. We performed sensitivity and subgroup analyses, and estimated number of events prevented.We analysed 1 651 675 hospital admissions. Introduction of smoke-free legislation was followed by an immediate reduction in RTI admissions (−3.5%, 95% CI −4.7– −2.3%), this mainly being attributable to a decrease in lower RTI admissions (−13.8%, 95% CI −15.6– −12.0%). The reductions in admissions for upper RTI were more incremental.The introduction of national smoke-free legislation in England was associated with ∼11 000 fewer hospital admissions per year for RTIs in children.
Criteria for diagnosis of exercise pulmonary hypertension
Authors: Herve Philippe , Lau Edmund M. , Sitbon Olivier , Savale Laurent , Montani David , Godinas Laurent , Lador Frederic , Jaïs Xavier , Parent Florence , Günther Sven , Humbert Marc , Simonneau Gerald , Chemla Denis 
Published: May 2015

The previous definition of exercise pulmonary hypertension (PH) with a mean pulmonary artery pressure (mPAP) >30 mmHg was abandoned because healthy individuals can exceed this threshold at high cardiac output (CO). We hypothesised that incorporating assessment of the pressure–flow relationship using the mPAP/CO ratio,i.e.total pulmonary resistance (TPR), might enhance the accuracy of diagnosing an abnormal exercise haemodynamic response.Exercise haemodynamics were evaluated in 169 consecutive subjects with normal resting mPAP ≤20 mmHg. Subjects were classified into controls without heart or lung disease (n=68)versuspatients with pulmonary vascular disease (PVD) (n=49) and left heart disease (LHD) (n=52).TPR and mPAP at maximal exercise produced diagnostic accuracy with area under the receiver operating curve of 0.99 and 0.95, respectively, for discriminating controlsversuspatients with PVD and LHD. The old criterion of mPAP >30 mmHg had sensitivity of 0.98 but specificity of 0.77. Combining maximal mPAP >30 mmHg and TPR >3 mmHg·min·L−1retained sensitivity at 0.93 but improved specificity to 1.0. The accuracy of the combined criteria was high across different age groups, sex, body mass index and diagnosis (PVD or LHD).Combining mPAP >30 mmHg and TPR >3 mmHg·min·L−1is superior to mPAP >30 mmHg alone for defining a pathological haemodynamic response of the pulmonary circulation during exercise.
Evaluation of macrolides for possible use against multidrug-resistantMycobacterium tuberculosis
Authors: van der Paardt Anne-Fleur , Wilffert Bob , Akkerman Onno W. , de Lange Wiel C.M. , van Soolingen Dick , Sinha Bhanu , van der Werf Tjip S. , Kosterink Jos G.W. , Alffenaar Jan-Willem C. 
Published: May 2015

Multidrug-resistant tuberculosis (MDR-TB) is a major global health problem. The loss of susceptibility to an increasing number of drugs behoves us to consider the evaluation of non-traditional anti-tuberculosis drugs.Clarithromycin, a macrolide antibiotic, is defined as a group 5 anti-tuberculosis drug by the World Health Organization; however, its role or efficacy in the treatment of MDR-TB is unclear. A systematic review of the literature was conducted to summarise the evidence for the activity of macrolides against MDR-TB, by evaluatingin vitro, in vivoand clinical studies. PubMed and Embase were searched for English language articles up to May 2014.Even though high minimum inhibitory concentration values are usually found, suggesting low activity againstMycobacterium tuberculosis, the potential benefits of macrolides are their accumulation in the relevant compartments and cells in the lungs, their immunomodulatory effects and their synergistic activity with other anti-TB drugs.A future perspective may be use of more potent macrolide analogues to enhance the activity of the treatment regimen.
Innate lymphocyte cells in asthma phenotypes
Authors: Ozyigit Leyla Pur , Morita Hideaki , Akdis Mubeccel 
Published: May 2015

AbstractT helper type 2 (TH2) cells were previously thought to be the main initiating effector cell type in asthma; however, exaggerated TH2 cell activities alone were insufficient to explain all aspects of asthma. Asthma is a heterogeneous syndrome comprising different phenotypes that are characterized by their different clinical features, treatment responses, and inflammation patterns. The most‐studied subgroups of asthma include TH2‐associated early‐onset allergic asthma, late‐onset persistent eosinophilic asthma, virus‐induced asthma, obesity‐related asthma, and neutrophilic asthma. The recent discovery of human innate lymphoid cells capable of rapidly producing large amounts of cytokines upon activation and the mouse data pointing to an essential role for these cells in asthma models have emphasized the important role of the innate immune system in asthma and have provided a new means of better understanding asthma mechanisms and differentiating its phenotypes.
Generalized contraction mapping principle and generalized best proximity point theorems in probabilistic metric spaces
Authors: Su Yongfu , Gao Wenbiao , Yao Jen-Chih 
Published: May 2015

AbstractThe purpose of this paper is to introduce some basic definitions about fixed point and best proximity point in two classes of probabilistic metric spaces and to prove contraction mapping principle and relevant best proximity point theorems. The first class is the so-called S-probabilistic metric spaces. In S-probabilistic metric spaces, the generalized contraction mapping principle and generalized best proximity point theorems have been proved by authors. These results improve and extend the recent results of Su and Zhang (Fixed Point Theory Appl. 2014:170, 2014). The second class is the so-called Menger probabilistic metric spaces. In Menger probabilistic metric spaces, the contraction mapping principle and relevant best proximity point theorems have been proved by authors. These results also improve and extend the results of many authors. In order to get the results of this paper, some new methods have been used. Meanwhile some error estimate inequalities have been established.
Feasibility of CO2 plume detection using 4D seismic: CO2CRC Otway Project case study — Part 1: Rock-physics modeling
Authors: Caspari Eva , Pevzner Roman , Gurevich Boris , Dance Tess , Ennis-King Jonathan , Cinar Yildiray , Lebedev Maxim 
Published: May 2015

A key objective of stage 2 of the Cooperative Research Centre for Greenhouse Gas Technologies Otway Project is to evaluate the seismic detection limit of greenhouse gas injected into a saline aquifer. For this purpose, injection of a small amount of [Formula: see text]-rich gas into the Paaratte Formation, a saline aquifer located at a depth of approximately 1.5 km, is planned. Before the injection experiment is undertaken, we assessed the detectability of injected gas with seismic methods in a modeling study. A key objective of this study was to model changes in elastic properties caused by [Formula: see text]-saturation effects using predictions of reservoir simulations. To this end, we established an elastic property/porosity relation to link the reservoir flow model and the elastic properties of the subsurface. Predicting changes in elastic properties requires suitable velocity-saturation relations. To choose an appropriate velocity-saturation relation, we analyzed the effect of fluid distribution on the time-lapse seismic response by performing 1.5D poroelastic and elastic modeling based on reservoir simulations. The modeling results emphasized the importance of taking the variability of rock properties into account and to carefully estimate dry bulk moduli to adequately represent the sensitivity of rock properties to fluid changes. Furthermore, we determined that the Gassmann-Wood relation was an appropriate velocity-saturation relation at seismic frequencies for the Paaratte Formation. However, changes in acoustic contrasts caused by [Formula: see text] saturation between layers below the seismic resolution had to be considered. In this sense, an appropriate velocity-saturation relation also depends on the scale at which we model the seismic response.
Interferometric salt-flank estimation
Authors: Karrenbach Martin , Warneke Joel , Cole Steve , Emuh Melissa 
Published: May 2015

Accurately determining the position of salt-sediment interfaces is important in oil and gas exploration, salt mining, and [Formula: see text] or oil and gas storage operations. We used seismic waves from a vertical seismic profile conducted above a salt dome in Texas to image a 2D vertical slice of the salt flank that was longer than can be obtained with traditional depth migration methods alone. This was possible by combining interferometric imaging methods with data from 100 3C receiver positions over a 1524 m (5000 ft) spread in a borehole close to the flank. Interferometry was used to construct virtual source gathers at the receiver positions within the salt body. This velocity-independent redatuming process effectively moved the sources from the surface to the borehole, removed complications of the overlying geology, and provided favorable illumination of the suspected flank position. Full-waveform elastic forward modeling helped us to understand and confirm the flank position. From the processed virtual source data, we created a 2D image in the source-receiver plane. In effect, we have created an imaging problem geometrically equivalent to that of a simple 2D surface seismic line rotated by 90°, with the requirement that we knew the velocity model only within the salt body. Interferometric imaging of the salt flank reduced the picking ambiguity and provided a direct depth image that was unaffected by overburden effects where the salt-flank location could be interpreted more confidently. Ultimately, we were able to image the salt flank over 1371 m (4500 ft) of depth with a lateral resolution in the order of 45–60 m (150–200 ft). The original data were obtained with more traditional imaging methods and cost considerations in mind, but the emergence of interferometric imaging methods suggested significant improvements to the acquisition strategy that would optimize the illumination of the subsurface.
NMR Detection and Characterization of I-quartets in Parallel DNA Quadruplexes
Authors: Kinoshita Masashi , Takaya Shunsuke , Shibata Tomokazu , Hemmi Hikaru , Yamamoto Yasuhiko 
Published: May 2015

Abstract
Four inosine bases (Is) can be cyclically and planarly associated through four hydrogen bonds to form a macrocycle called an I-quartet, in a manner similar to that of the well-known guanine (G)-one. We identified and characterized I-quartets formed in parallel DNA quadruplexes using 1H NMR. Comparative studies on I- and G-quartets formed in parallel DNA quadruplexes revealed remarkable differences in their physicochemical properties that could be interpreted in terms of buckling of the quartet plane.
Stable Perovskite Solar Cells Based on WO3 Nanocrystals as Hole Transport Layer
Authors: Li Zhiwei 
Published: May 2015

Abstract
Hybrid organic/inorganic perovskite solar cells have been rapidly developed with spectacular success in both nanostructured and thin-film versions. Herein, we report a simple solvothermal method using WCl6 and NH3·H2O as precursors in ethanol solvent at 200 °C for 24 h to fabricate WO3 nanocrystals (NCs) as the hole transport layer in an inverted perovskite solar cell. The thin WO3 NC film with a smooth and compact surface enabled the formation of a continuous and compact layer of well-crystallized CH3NH3PbI3 in a two-step solution process. A cell efficiency of 7.68% was obtained, which is a promising planar perovskite solar cell based on an inorganic hole extraction layer.
Reinterpretacje romantyzmu
Authors: Kuciński Paweł 
Published: May 2015

Reinterpretations of Romanticism. Radical Nationalism Towards the Legacy of the Age of Bardes
In the presented article the author is studying arguments occurring between the nationalism in its radical version and with poetry engendered in the environment of Polish national radicals in the 30. of XX century. These groups have often appealed to the Polish literary tradition, mainly of Romanticism and included in it (then taken over and reinterpretated by Polish nationalists) topoi (topoi of flight, youth, idealism).
Białoruskość jako idée fixe twórczości Sokrata Janowicza
Authors: Sawicka-Macierzyńska Katarzyna 
Published: May 2015

Belarussian Identity as an Idée Fixe of Sokrat Janowicz’s work
This article contains reflections on methods of creating the Belarussian national identity by Sokrat Janowicz, a Belarussian writer from Podlasie. Belarussian identity is treated as a kind of narrative strategy, which uses the authority of historicism and the principle of difference (in Derrida’s meaning). The inspiration of these considerations are H.K. Bhabha’s views on Postcolonialism, described in The Location of Culture. The introductory part of the article shows a short description of Belarussians as a national minority.