bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of low-frequency ultrasound and microbubbles on rabbit hepatic tumors
Authors: Shen Zhi-Yong , Xia Gan-Lin , Wu Ming-Feng , Shi Min-Xin , Qiang Fu-Lin , Shen E , Hu Bing 
Published: April 2014

High-intensity focused ultrasound in combination with microbubbles (MBs) is able to inhibit the growth of VX2 rabbit liver tumors in vivo and prolong the survival time of the animals. In this study, we attempt to investigate the feasibility of VX2 tumor growth inhibition using low-frequency ultrasound (US)-mediated MB disruption. Forty-eight New Zealand rabbits with hepatic VX2 tumors were divided into four groups: control, MBs group, low-frequency US group, and US + MB group. The parameters of the US were 20 kHz, 2 W/cm2, 40% duty cycle, 5 min, and once every other day for 2 weeks. At the end of the therapy experiment, 24 rabbits were euthanized, and the cancers were collected and cut into five sections for histological examination, immunohistochemistry, laser confocal microscopy, western blotting assays, and transmission electron microscopy (TEM). Another 24 rabbits were saved, and overall survival time was recorded. The tumor volumes in control, MB, US, and US + MB groups were 6.36 ± 0.58, 5.68 ± 0.42, 5.29 ± 0.26, and 2.04 ± 0.14 cm3, respectively (US + MB versus the other three groups, P < 0.01). Tumor cells manifested coagulation necrosis with internal calcification. Hematoxylin and eosin (H–E) staining revealed interstitial hemorrhage and intravascular thrombosis. The intensity of cyclooxygenase-2 (COX-2), and vascular endothelial growth factor (VEGF) in the US + MB group in the immunohistochemical staining, laser confocal microscopy, and western blotting assays was lower than that of the other three groups ( P < 0.05). TEM of the US + MB group revealed vascular endothelial cell wall rupture, widened endothelial cell gaps, interstitial erythrocyte leakage, and microvascular thrombosis, while intact vascular endothelial cells and normal erythrocytes in the tumor vessels were observed in control, MB, and US groups. Rabbits treated with US + MB had a significantly longer overall survival than those in the other three groups (χ2 = 9.328, P = 0.0242). VX2 tumor growth could be inhibited by cavitation induced using low-frequency US and MB.
Calm Technologies: A New Trend for Educational Technologies
Authors: Tugui Alexandru 
Published: April 2014

Over the last 50 years, technological development has been significantly influenced by computers and associated technologies. The massive investments made in information technology and communication development have benefitted all the world's economies, and especially the interconnected ones. All business areas have therefore adopted computers as an indispensable tool, and all economic and social processes have come to rely on computers for support and intermediation. The education field has been, and will continue to be, receptive to the evolutions of information- and communications-related technologies. Educators will use them on a wide scale in projects such as e-books, e-learning, university networks, and digital libraries. Technological miniaturization and steady improvements in performance have resulted in the abandonment of classical technologies (white chalk, blackboard, paper, pencil, etc.) and their extensive replacement by PC tablet, video projectors, intelligent boards, e-pen, and other new applications. According to various authors, deculturalization is one megatrend predictable for the long-term future of human society. Information technologies and communication will become increasingly omnipresent and will progressively acquire calm technology characteristics. The purpose of this paper is to focus on the contribution that these new educational technologies may have on deculturalization, and on the role of calm technologies in education.
Challenging the dogma: a randomized trial of standard vs. half‐dose concomitant nonbismuth quadruple therapy for Helicobacter pylori infection
Authors: Sharara Ala I , Sarkis Fayez S , El-Halabi Mustapha M , Malli Ahmad , Mansour Nabil M , Azar Cecilio , Eloubeidi Mohamad A , Mourad Fadi H , Barada Kassem , Sukkarieh Ismail 
Published: April 2014

BackgroundCurrent treatment of Helicobacter pylori consists of three or four drugs for 7–14 days with important associated cost and adverse events.AimsThis study compared efficacy and safety of standard dose vs. half‐dose concomitant nonbismuth quadruple therapy (NBQT) for 7 days. The standard dose consisted of twice daily rabeprazole 20 mg, amoxicillin 1 g, metronidazole 500 mg, and clarithromycin 500 mg.MethodsThis was a prospective randomized trial. 14 C‐urea breath test was performed ≥4 weeks after treatment and ≥2 weeks off acid suppressive therapy. Compliance and adverse events were monitored during treatment.ResultsA total of 200 consecutive treatment‐naïve patients were enrolled. Baseline characteristics were similar between groups, with 15.5% of subjects reporting prior macrolide use. Eradication occurred in 78% (95% CI 68.6–85.7%) in both groups on intention‐to‐treat analysis. Per‐protocol rates were 82.1 vs. 83.9% for standard‐dose patients vs. half‐dose patients, respectively (p  = NS). Adverse events (only mild) were reported in 57 vs. 41% of standard‐dose patients vs. half‐dose patients (p  = 0.024), with metallic taste and nausea notably less frequent in the latter (36 vs. 12% and 18 vs. 7%, respectively; p  < 0.05 for both). Overall, eradication failed in 38.7% of prior macrolide users vs. 18.9% without such exposure (p  = 0.019). On multivariate logistic regression, prior macrolide exposure was the only factor associated with failed eradication (OR 2.60, 95% CI 1.06–6.39; p  = 0.038). Treatment was cheaper with the half‐dose regimen.InterpretationA 50% reduction in antibiotic dosage does not diminish efficacy of concomitant nonbismuth quadruple therapy but leads to significant reduction in cost and adverse events. Seven‐day concomitant NBQT is suboptimal for H. pylori independent of prior macrolide exposure.
Time to antibiotics and outcomes in cancer patients with febrile neutropenia
Authors: Perron Thomas , Emara Mohamed , Ahmed Shahid 
Published: April 2014

Abstract

Background
Febrile neutropenia is an oncologic emergency. The timing of antibiotics administration in patients with febrile neutropenia may result in adverse outcomes. Our study aims to determine time-to- antibiotic administration in patients with febrile neutropenia, and its relationship with length of hospital stay, intensive care unit monitoring, and hospital mortality.

Methods
The study population was comprised of adult cancer patients with febrile neutropenia who were hospitalized, at a tertiary care hospital, between January 2010 and December 2011. Using Multination Association of Supportive Care in Cancer (MASCC) risk score, the study cohort was divided into high and low risk groups. A multivariate regression analysis was performed to assess relationship between time-to- antibiotic administration and various outcome variables.

Results
One hundred and five eligible patients with median age of 60 years (range: 18–89) and M:F of 43:62 were identified. Thirty-seven (35%) patients were in MASCC high risk group. Median time-to- antibiotic administration was 2.5 hrs (range: 0.03-50) and median length of hospital stay was 6 days (range: 1–57). In the multivariate analysis time-to- antibiotic administration (regression coefficient [RC]: 0.31 days [95% CI: 0.13-0.48]), known source of fever (RC: 4.1 days [95% CI: 0.76-7.5]), and MASCC high risk group (RC: 4 days [95% CI: 1.1-7.0]) were significantly correlated with longer hospital stay. Of 105 patients, 5 (4.7%) died & or required ICU monitoring. In multivariate analysis no variables significantly correlated with mortality or ICU monitoring.

Conclusions
Our study revealed that delay in antibiotics administration has been associated with a longer hospital stay.
That “certain cut”: towards a characterology of Mandarin Chinese
Authors: Halliday MAK 
Published: April 2014

AbstractIn his book Language: An Introduction to the Study of Speech, published in 1921, Edward Sapir wrote that ‘ … there is such a thing as a basic plan, a certain cut, to each language’. Linguists of the Prague school referred to the “characterology” of language; for example Vilém Mathesius, in his article ‘On linguistic characterology with illustrations from Modern English’ written in 1928, wrote that ‘… linguistic characterology deals only with the important and fundamental features of a given language at a given point in time’, noting as an example that ‘… Modern English shows a characteristic tendency for the thematic conception of the subject’. It is a concept that proves extremely difficult to make explicit; whatever it is that constitutes the unity of all the components of the picture seems elusive. Can we give any overall characterisation of that ‘certain cut’, or is it simply ineffable?
Teachers and teacher aides initiating five-year-olds into science
Authors: Thwaite Anne 
Published: April 2014

AbstractApprenticing children into discourses necessary for success at school begins at a very early age. In this paper I look at five-years-olds being introduced to Science and Technology while at the same time being involved in talk around literacy. The various adults who surround the children engage differentially in talk and action while merging the discourses of literacy and science.Data for this study were obtained during the course of the project ‘Early literacy through science in Indigenous and culturally diverse communities’, funded by Edith Cowan University in Australia from 2009–2010, in which the author was involved as a researcher. The project involved observing and recording a series of lessons over nine weeks in a Pre-Primary classroom of five year-olds from diverse backgrounds in a metropolitan school. Various functional analyses were used in order to bring out some of the differences in the discourse of the trained teachers compared with that of the other adults working with the children. Analyses included Field, Tenor, Exchange Structure and Speech Function. Differences were apparent in the structure of the discourse, Questions, Commands, vocabulary and the teacher-student relationships. As an example of the contrast between teachers and teacher aides, I look more closely at two lessons involving photography and use of electronic resources. These lessons show the teachers and the teacher aide constructing different relationships with the children and the teacher using a wider variety of linguistic resources in her interactions.
Activity and views of service users involved in mental health research: UK survey
Authors: Patterson Sue , Trite Jenny , Weaver Tim 
Published: April 2014

BackgroundOptimisation of the process and outcomes of service user involvement in research is dependent on understanding current practice, challenges and opportunities.AimsTo describe activities, roles and experiences of service users involved in mental health research.MethodNational cross-sectional online questionnaire survey, using snowball sampling. Descriptive statistics and framework analysis undertaken collaboratively with a service user reference group.ResultsThe survey revealed a previously undescribed, highly qualified service user research workforce. Positioned within and alongside mainstream research, respondents reported drawing on extensive service use, and passion for service improvement to challenge perceived clinical academic dominance of research. The support of peers was crucial to involvement, which typically enhanced mental health but for some, pervasive stigma and scrutiny undermined self-confidence and practical difficulties challenged equitable participation.ConclusionsRecognition of the service user research workforce will support the constructive amalgamation of academic and experiential expertise needed to shape and realise investment in mental health research.
A multivariate analysis of the partitive genitive in Dutch. Bringing quantitative data into a theoretical discussion
Authors: Pijpops Dirk , Van de Velde Freek 
Published: April 2014

Abstract
This article takes a usage-based perspective on the partitive genitive construction in Dutch (iets moois, ‘something beautiful’), which has previously drawn scholarly attention from a theoretical perspective, due to the challenges it presents to Dutch nominal morphosyntax. We will argue that a good understanding of the construction at issue cannot circumvent the enormous variation in the expression of the genitive marker. Within the wide variation space, regular patterns can be discerned, which we uncovered by using mixed-effects logistic regression. This approach allows us to assess the precise contribution of internal factors (e.g. length of the adjective, or the type of quantifier) and external factors (e.g. regional variety, or register), as well as their interactions. This article has three objectives then: first, it wants to contribute to the description of Dutch syntax, second it aspires to advance methodological standards in grammatical investigation, and third, it makes a theoretical plea for a usage-based perspective, with full recognition of variation.
Periphere Kooperation am Beispiel der Anschläge in Norwegen 2011 / Peripheral Cooperation in Crises: Norway 22/7/11
Authors: Büscher Monika , Perng Sung-Yueh , Weise Sebastian 
Published: April 2014

Zusammenfassung
Dieser Beitrag thematisiert, wie Zivilbürger während der Anschläge in Norwegen vom 22. Juli 2011 soziale Medien nutzten um Hilfe zu leisten. Bei den Anschlägen detonierte der Attentäter Anders Behring Breivik zunächst eine Bombe in Oslo und riss acht Menschen in den Tod. Danach fuhr er auf die 40 Kilometer entfernte Insel Utøya, wo er 69 Jugendliche ermordete. Unsere Analyse erarbeitet ein neues Konzept der „peripheren Kooperation”, um die öffentliche Beteiligung an der Ressourcenmobilisierung am Rande der offiziellen Krisenhilfe besser zu beschreiben.
Kreative Nutzung der verfügbaren Netzwerkinfrastruktur im Katastrophenfall / Creative usage of available network infrastructure in disaster situations
Authors: Al-Akkad Amro , Boden Alexander 
Published: April 2014

Zusammenfassung
In diesem Beitrag untersuchen wir Herausforderungen für Nutzer von mobilen Geräten in Situationen, in denen die Netzwerkinfrastruktur gestört ist. Ein besonderer Fokus liegt dabei auf den durch Nutzer entwickelten Strategien, um solche Störungen mit Überbleibseln der Infrastruktur zu umgehen und ihre Fähigkeit zur mobilen Kommunikation wiederherzustellen. Aufbauend auf Interviews mit Nutzern, die Krisensituationen erlebt haben, sowie mit professionellen Ersthelfern, Berichten über Katastrophen und der einschlägigen Literatur beschreiben wir fünf architektonische Qualitäten, die die Resilienz von Systemen für Krisenkommunikation bei Ausfällen der Kommunikationsinfrastruktur erhöhen können. Dazu zeigen wir beispielhaft anhand zweier von uns entwickelter Prototypen, wie diese auf Basis etablierter Technologien umgesetzt werden können.
Zeitliche Verläufe emotionaler Aktivierung in der Mensch-Technik-Interaktion / Temporal dynamics of emotional activation in man-machine interaction
Authors: Backhaus Nils , Brandenburg Stefan 
Published: April 2014

Zusammenfassung
Bei der Interaktion mit technischen Geräten spielt das emotionale Nutzererleben (UX, User Experience) eine große Rolle. Die vorliegende Studie untersuchte zwei UX-Aspekte. Zum einen wurde die Möglichkeit der Induktion von Emotionen (Frustration und Freude) durch die Interaktion mit einer interaktiven Spielekonsole untersucht, zum anderen stand der Einfluss dieser Induktion auf die Touch-Interaktion mit einem Tablet im Fokus der Untersuchung. Die Studienergebnisse legen nahe, dass es möglich ist, mit einer interaktiven, bewegungsgesteuerten Spielekonsole gezielt distinkte Emotionen zu induzieren. Darüber hinaus zeigten sich eigene Dynamiken für Frustration und Freude innerhalb der nachfolgenden Interaktion mit dem Tablet-PC. Letztlich war die Emotionsinduktion jedoch nicht stabil genug, um die Leistungen im Kontext der Touch-Interaktion zu beeinflussen. Die Ergebnisse werden vor dem Hintergrund von emotionalen Dynamiken, contextual change und der UX-Forschung diskutiert.
Selection Method of Customer Partners in Customer Collaborative Product Innovation
Authors: Li Fei , Yang Yu , Xie Jianzhong , Liu Aijun , Chen Qian 
Published: April 2014

AbstractPartner selection is an important aspect of the customer collaborative product innovation process and aims to select innovative customer partners from huge numbers of customers, fast and accurately. The purpose of this article is to present a quantitative partner selection method based on the complex network theory. In this method, the complex network model of the Online Community Customer Network (OCCN) is constructed, and network centrality is used as the initial index of customer partner selection. Then, network efficiency and delta centrality are used to evaluate the effect of the index. An example is presented to reflect the feasibility and efficiency of the proposed method. Results validate the small-world and scale-free properties of the OCCN and show that betweenness centrality is the most appropriate index for partner selection in the OCCN.
Derivational gender in Moroccan Berber: examples from Ayt Seghrushen
Authors: Kossmann Maarten 
Published: April 2014

Abstract
Berber languages have a two-term gender opposition. Most nouns are allowed to appear in both genders, expressing meaning differences such as natural gender and size. Nouns have a neutral gender value, which is lexically determined, and a derivation which is marked by the opposite gender. In the case of size differences, this leads to a ternary opposition (diminutive – neutral – augmentative), expressed by only two genders. The grammatical constraint on the number of values is sometimes circumvened by using different allomorphs of gender morphemes. With a number of sub-classes of nouns a ternary opposition is made possible by a change in morphological sub-class.
Topicalization in Berber: a typological perspective
Authors: Lafkioui Mena 
Published: April 2014

Abstract
This article addresses the phenomenon of topicalization from a typological perspective, both at the level of the Berber phylum and at the crosslinguistic level. It aims at providing Berber's principal linguistic properties and mechanisms of topicalization in comparison with cross-linguistic accounts so as to better understand the connection between syntax and information structure, which in Berber is subject to variation and to a complex interplay with prosody.
The Effect of Three Desensitizing Agents on Dentin Hypersensitivity: A Randomized, Split-mouth Clinical Trial
Authors: Torres CRG , Silva TM , Fonseca BM , Sales ALLS , Holleben P , Di Nicolo R , Borges AB 
Published: April 2014

SUMMARYThe aim of this study was to evaluate the efficacy of three desensitizing agents to provide relief to dentin hypersensitivity after one session in a four-week follow-up. Forty selected patients participated in a double-blind study following a split-mouth model. One application of the desensitizing agents (A, Admira Protect [Voco]; B, Bifluorid 12 [Voco]; and C, Colgate Pro-Relief in office [Colgate Palmolive]) was performed in three different quadrants for each patient. Each tooth was evaluated by tactile and evaporative stimuli, and the sensitivity response was measured using the Visual Analogue Scale. Evaluations were performed at baseline, immediately after treatment, and after one, two, three, and four weeks. The application of Kruskal-Wallis and Dunn multiple comparisons tests (5%) for both tactile and evaporative stimuli showed that all agents presented a significant desensitizing effect. In groups A and B this relief was maintained for four and three weeks, respectively, as measured by tactile stimulus and for four weeks with evaporative stimulus. The desensitizing effect for group C was maintained for two weeks for both tactile and evaporative stimuli. It is concluded that all desensitizing agents tested were effective in reducing sensitivity compared to baseline values. One application of Admira Protect and Bifluorid 12 presented a longer-lasting desensitizing effect than did Colgate Pro-Relief (applied in the office) on both tactile and evaporative stimuli.
Effect of Water Storage on the Flexural Strength of Four Self-etching Adhesive Resin Cements and on the Dentin-titanium Shear Bond Strength Mediated by Them
Authors: Schittly E , Le Goff S , Besnault C , Sadoun M , Ruse ND 
Published: April 2014

SUMMARY

Aim
The aim of this study was to evaluate the effect of water storage on the flexural strength (σf) of four self-etching adhesive resin cements (SEARC) and on the dentin-titanium shear bond strength (SBS) mediated by them.

Materials and Methods
The selected SEARC were Rely X Unicem, G-Cem, Maxcem, and SmartCem2. For each material, 50 bars (2×2×25 mm) were made and stored in water at 37°C for 1 hour, 1 day, 7 days, 30 days, and 60 days before σf was determined via a three-point bend test. Titanium cylinders were bonded to freshly exposed human dentin surfaces using the selected cements. Fifty samples were obtained for each SEARC and were stored in water at 37°C for 1 hour, 1 day, 7 days, 30 days, and 60 days before SBS was determined. The results were statistically analyzed using two-way analysis of variance followed by Scheffé multiple means comparisons (α=0.05). Pearson's correlation coefficient between σf and SBS was determined.

Results
Significantly different σf and SBS values were obtained for the four cements. With regards to the effect of water storage, the σf of all materials increased during the first 7 days, was not significantly different between materials by 30 days, and then remained relatively constant or decreased for SmartCem2; SBS was not affected by water storage, with the exception of Maxcem, where a significant drop in SBS was detected after 1 day and no deterioration thereafter. No correlation was found between σf and SBS.

Conclusions
Under the experimental conditions of this study, 60 days of water storage negatively affected the σf of SmartCem2 but did not negatively affect the SEARC-mediated dentin-titanium SBS (Maxcem showed a significant drop in SBS after 1 day but no deterioration thereafter). The dentin-titanium adherence afforded by Rely X and G-Cem was significantly higher than that of Maxcem and SmartCem2.
In Search of a Different History: The Remains of Burlesque in Montreal
Authors: Mansbridge Joanna 
Published: April 2014

Abstract: Taking Elin Diamond’s and Rebecca Schneider’s recent work in drama and performance studies as a starting point, this essay looks at two eras of burlesque in Montreal—the 1940s-50s and 2012—tracing a shifting landscape of popular entertainment, politics, religion, and social attitudes toward female sexuality. There is a central question underlying this examination: Why burlesque? Why now (or, rather, again?). I argue that burlesque offers an archive that evokes a different, more glamorous history than the one passed down to women by second-wave feminism. Burlesque also provides an alternative to popular culture’s commodification of female sexuality, technology’s mediation of social life, and heteronormative culture’s privatization of sexuality, giving women—and men—a stage on which to make fun of our cultural fixation with sex and the female body. Both nostalgically looking back and eagerly reaching for the new, neo-burlesque repeats the past as it simultaneously reinvents it.