bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water quality for citizen confidence: The implementation process of 2020 EU Drinking Water Directive in Nordic countries
Authors: Bayona-Valderrama Ángela , Gunnarsdóttir María J. , Rossi Pekka M. , Albrechtsen Hans-Jörgen , Gerlach Bergkvist Kim Steve , Gardarsson Sigurður M. , Eriksson Magnus , Truelstrup Hansen Lisbeth , Jensen Pernille Erland , Maréchal Judith Y. A. , Myrmel Mette , Persson Kenneth M. , Bjerkén August , Kalheim Frida Celius , Bartram Jamie 
Published: July 2024

ABSTRACT

The European Union Drinking Water Directive aims to protect human health and promote safe water consumption. The 2020 revision, particularly Article 17, directed member states to provide public access to information on drinking water. This update responded to citizen initiatives calling for the active participation of end-users in water services and greater transparency from water utilities. Difficulties in implementing previous versions of the directive highlighted divergences between policy purposes, local capacity to implement, and public response. These divergences are explored through eight case studies of Nordic countries and analysed using the policy implementation framework. We employed a mixed-method, multi-stage approach. Policy formulation was characterized through a literature review, policy design by synthesizing legislative instruments, and policy implementation via an analysis of delivery behaviour based on interviews. We identified the main drivers of the directive's update and contrasted these with the ongoing implementation process in the countries studied. Our results point to a different and highly contextual implementation, which differs from the primary drivers of the policy update, namely, the establishment of public confidence in water services.
An Extensive Pharmacological Evaluation of New Anti-carcinoma CDK1 and SERPINE1 Targeted Compound Homoorientin from T.officinale's with In-depth Molecular Docking and Simulation Studies
Authors: Shaikh Abdul Lateef , Zhou Lin , Zheng Shusen 
Published: July 2024

Introduction:
Hepatitis B Virus-Related Hepatocellular Carcinoma (HBV-
HCC) constitutes a formidable global health challenge, demanding an in-depth understanding
of its intricate pathogenesis. The research conducted a comprehensive analysis
of the multifaceted relationship between HBV-HCC. It further examined the potential of
Taraxacum officinale, which could serve as an effective adjunct therapy in treating HBV-
associated HCC. Our approach integrates network pharmacology, pathway analysis,
molecular docking, and dynamics simulations, offering an intricate unraveling of the
molecular mechanisms that underlie T. officinale's potential impact on HBV-HCC.

Method:
Additionally, we delve into microarray analysis to unearth differentially expressed
genes (DEGs) associated with HBV-HCC, molecular docking to validate compound
interactions with key proteins, and molecular dynamics simulations to elucidate
the stability of these interactions. These multifaceted approaches enhance our understanding
of T. officinale's therapeutic potential.

Results:
This work represents a significant advancement toward the development of
more effective strategies for the management of this challenging disease, offering a comprehensive
exploration of T. officinale's therapeutic prowess. Within this multidimensional
framework, we identify CDK1, SERPINE1, and PTGS2 as promising therapeutic targets,
shedding light on the molecular intricacies of disease progression. Further, Homoorientin
from T. officinale's demonstrates a strong binding affinity with proteins CDK1,
SERPINE1, and PTGS2, suggesting a potential synergistic effect in therapeutic applications.
Moreover, our enrichment analysis uncovers a rich tapestry of pathways enriched
in HBV-HCC, providing insights into the multifaceted landscape of disease complexity.

Conclusion:
These findings not only pave the way for potential targeted therapies but also
deepen our comprehension of the intricate molecular underpinnings of HBV-HCC.
This work represents a significant advancement toward the development of more effective
strategies for the management of this challenging disease, offering a multifaceted
exploration of T. officinale's therapeutic potential.

other:
Nil
Green Synthesis of Bioactive Pyrrole Derivatives via Heterogeneous Catalysts Since 2010
Authors: Amina Berrichi , Redouane Bachir 
Published: July 2024

1:
Pyrrole derivatives are known as building blocks for the synthesis of biological
compounds and pharmaceutical drugs. Several processes were employed to synthesize pyrroles,
including Hantzsch, Paal-Knorr, and cycloaddition of dicarbonyl compounds reaction. Using
catalysts like nanoparticles, metal salts, and heterogeneous ones was necessary to obtain the
targeted pyrrole structure. Also, to afford more active pyrrole compounds, heterocyclic molecules
such as imidazole or other rings were used in the synthesis as amines. This review presents
heterogeneous catalysts since 2010 for the green synthesis of bioactive pyrroles in a one-pot
multi-component reaction.

:
Additionally, each synthetic method included a demonstration of the suggested mechanisms.
Diakylacetylenedicarboxylate, dicarbonyl group, amines, furans, and acetylene group are
consolidated to yield biological pyrroles through the heterogeneous catalysts. Finally, various
pyrrole-performed activities were displayed, such as antibacterial, anti-inflammatory, analgesic,
and other significant activities.
Efficacy of Marma Chikitsa in the Pain Management of Tennis Elbow - A Single Case Study
Authors: Deependra Singh Rathore  , Rita Marwaha  , Nisha Bhalerao  , Swatantra Kumar Chourasia  
Published: July 2024

Tennis elbow, also known as lateral epicondylitis, is a condition that can result from overuse of the muscles and tendons in the elbow. Tennis elbow is linked to repeated motions of the wrist and arm. Tennis elbow is often due to damage to a specific forearm muscle extensor carpi radialis brevis (ECRB). When the ECRB muscle is weakened from overuse, microscopic tears form in the ECRB tendon where it attaches to the lateral epicondyle of humerus. This leads to pain directly over the outside lateral part of the elbow. 1 to 3% of adult population in each year affects with tennis elbow and it is more common in the dominant arm with symptoms such as pain or burning on the outer part of your elbow, weak grip strength, and tenderness. Many surgical procedures, medications are present today for the treatment of the disease, but it is the need of time to develop some non-invasive techniques for better results. Marma is a concept which helps in achieving this. Marma point is a junction on body where two or more types of tissue meet, such as muscles, veins, ligaments, bones or joints. From common ailments to serious neuromuscular diseases, all can be treated by Marma Chikitsa. Application of pressure to these Marma induces the flow of energy. This case study shows that pain in tennis elbow may be successfully managed by Marma Chikitsa.
Optimalisasi pendidikan informal sebagai alternatif pemertahanan bahasa Jawa
Authors: Alfiah Alfiah 
Published: July 2024

Tujuan penulisan ini adalah mendeskripsikan bentuk pengoptimalan upaya pendidikan informal sebagai upaya pemertahanan bahasa Jawa. Penulisan artikel ini dikembangkan dengan menggunakan penelitian deskriptif kualitatif dengan merujuk pada beberapa hasil penelitian yang menggambarkan berbagai fenomena bahasa Jawa di tengah masyarakat Jawa di era kini sebagai sumber datanya. Data dalam penelitain ini adalah berbagai bentuk-bentuk perubahan yang terjadi di tengah masyarakat Jawa era kini tentang eksistensi bahasa Jawa. Data dikumpulkan dengan teknik simak dan baca. Berdasarkan data yang terhimpun, dianalisis secara kritis berdasarkan fenomena atau peristiwa tertentu yang muncul terkait perkembangan bahasa Jawa dan menggunakan peneliti sebagai instumen utama. Hasil penelitian adalah keluarga merupakan lingkungan keluarga merupakan lingkungan pertama anak dalam hal memperoleh pendidikan dapat tumbuh dan berkembang dengan pemantauan dan pengawasan orang tua dan anggota keluarga lainnya yang hidup satu rumah dengannya. Pola asuh orang tua menentukan bagaimana perkembangan nilai karakter anak. Ibu sebagai salah satu orang yang dinilai paling dekat dengan anak memegang peran yang lebih dominan berperan sebagai pendidik dalam lembaga pendidikan informal. Anak memperoleh bahasa pertama dari bahasa yang digunakan di lingkungannya, terutama ibunya karena orang terdekat bagi anak. Ibu memainkan peran formatif dalam pemerolehan bahasa pertama pada anaknya
Kajian sosial budaya moda transportasi tradisional sampan Leper Indragiri Hilir
Authors: Afriadi Deni , Jefrizal Jefrizal , Idayanti Iik 
Published: July 2024

Penelitian ini fokus pada kajian sosial budaya tentang keberadaan Sampan Leper di Desa Pekan Arba Kecamatan Batang Tuaka, Kabupaten Indragiri Hilir, Provinsi Riau. Moda transportasi tradisional ini sudah ada sejak puluhan tahun yang lalu dan masih menjadi moda transportasi di tengah perkembangan dan banyaknya pilihan moda transportasi modern. Kajian ini menelaah keberadaan, peran serta fungsi Sampan Leper di tengah masyarakat Indragiri Hilir. Penelitian ini merupakan penelitian kualitatif dengan menggunakan teknik pengumpulan data analisis, wawancara dan dokumentasi. Adapun hasil dari penelitian ini menjabarkan tentang kondisi Sampan Leper, karakteristik masyarakat pengguna, fungsi sosial budaya, peran pelaku dan instansi terkait, pewarisan dan nilai sosial budaya. Sampan leper telah menjadi bagian integral dari kehidupan sehari-hari masyarakat di kawasan ini, terutama sebelum adanya pembangunan jembatan yang menghubungkan berbagai kampung. Pembangunan infrastruktur memang memberikan banyak manfaat, namun ada kekhawatiran bahwa tradisi dan kearifan lokal, seperti penggunaan sampan leper, dapat terancam punah jika tidak ada upaya yang dilakukan untuk melestarikannya.
Prevalencia de Cryptosporidium spp. en becerros doble propósito de la zona centro de Veracruz, México
Authors: Romero Salas Dora , Rodríguez-Vivas Roger Ivan , Cruz-Romero Anabel , Aguilar-Domínguez Mariel , Alarcón-Zapata Marco Antonio , Ojeda-Chi Melina Maribel , Flota-Burgos Gabriela Janett 
Published: July 2024

Objective. To estimate the prevalence of Cryptosporidium spp. in dual-purpose calves on cattle ranches in Veracruz, Mexico, by the use of the direct immunofluorescence test (DIT). Materials and methods. A cross-sectional epidemiological study was carried out in five municipalities of Veracruz. The animals included in the study were calves between 1 and 60 days old. Stool samples were taken directly from the rectum. The modified Faust centrifugation technique was used to concentrate oocysts and DIT for their detection. In each ranch surveys were applied to know the characteristics of the animals and their management. General and specific prevalence was estimated. Variables were analyzed using the univariate Chi-square test to determine possible epidemiological associations. Results. The overall prevalence of Cryptosporidium spp. was 69.9%, and the municipality with the highest prevalence was Tlalixcoyan (96.6%). No significant difference was found between the age, sex, breed and consistency of the feces of the calves. The ranch (R9) was the only factor associated with Cryptosporidium spp. in the calves studied. Conclusions. There is a high prevalence of Cryptosporidium spp. in dual purpose calves from Veracruz, Mexico. For a better understanding of the transmission dynamics and zoonotic potential of this protozoan, it is necessary to determine the predominant species and genotypes in the region.
STRATEGI SUPERVISI KLINIS KEPALA SEKOLAH DALAM PEMBINAAN KINERJA GURU DI SMAN 12 BANDA ACEH
Authors: Nurussalami Nurussalami , Muharrafah Nonadya 
Published: July 2024

Strategi supervisi klinis yang dilakukan oleh kepala sekolah memiliki peran yang sangat penting dalam pembinaan kinerja guru dalam membuat Rencana Pelaksanaan Pembelajaran (RPP). Melalui supervisi ini, guru dapat mengatasi berbagai masalah yang dihadapinya, sehingga kualitas pembelajaran dan kinerjanya dapat meningkat. Tujuan penelitian ini adalah (1) Untuk mengetahui perencanaan supervisi klinis kepala sekolah dalam pembinaan kinerja guru di SMAN 12 Banda Aceh, (2) Untuk mengetahui pelaksanaan supervisi klinis kepala sekolah dalam pembinaan kinerja guru di SMAN 12 Banda Aceh, (3) Untuk mengetahui peluang dan tantangan supervisi klinis kepala sekolah dalam pembinaan kinerja guru di SMAN 12 Banda Aceh. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data dilakukan melalui observasi, wawancara, dan dokumentasi dengan subjek penelitian yaitu kepala sekolah dan 2 orang guru. Hasil penelitian ini menunjukkan bahwa dalam perencanaan supervisi klinis, kepala sekolah melakukan langkah-langkah seperti menentukan tujuan supervisi klinis, mengumpulkan informasi, menentukan fokus supervisi klinis untuk setiap guru, menyusun rencana tindakan yang spesifik, menetapkan jadwal supervisi klinis, dan mengadakan pertemuan supervisi klinis. Pelaksanaan supervisi klinis terdiri dari tiga tahap yaitu pertemuan awal, observasi, dan pertemuan balikan. Tantangan yang dihadapi kepala sekolah dalam supervisi klinis adalah masalah komunikasi, kurangnya kerjasama, masalah teknis, dan tantangan waktu. Namun, supervisi klinis juga memberikan peluang untuk meningkatkan keterampilan mengajar dan kualitas pembelajaran, mengidentifikasi masalah, meningkatkan hubungan antara guru dan kepala sekolah, serta pengembangan profesional guru.
The Strategic Directions for the Development of the Electronic Industry in Russia
Authors: Shatskaya I. V. 
Published: July 2024

Topicality. The unprecedented sanctions policy against Russia forces us to think about the directions of development of the domestic economy. One of the priority directions is the development of the domestic electronic industry — the most knowledge-intensive branch of mechanical engineering, the structural core of the post-industrial wave in accordance with the wave concept of E. Toffler. It is electronic products, including components and products made from them, that are extremely differentiated and, among other things, serve as components for other industrial and consumer goods. This means that without the development of the electronic industry, the development of other spheres and sectors of the economy becomes difficult.Aim. To determine the basic strategy for the development of the electronic industry in Russia.Tasks. To identify the strategic role of innovations in electronics and microelectronics in Russia’s achievement of technological sovereignty.Methods. The article is based on the general theory of strategy and methodology of strategizing by academician, foreign member of the Russian Academy of Sciences V.L. Kvint, developed at the Center for Strategic Studies of the Institute for Mathematical Research of Complex Systems and the Department of Economic and Financial Strategy of Lomonosov Moscow State University.Results. The article provides an overview of global innovation trends and startups that are transforming the electronic industry today. In addition to the review, the author provides statistical information on the level of development of these technologies in Russia.Conclusions. The strategy for the development of the electronic industry in Russia should be based on a reorientation towards innovative products and components, as well as innovative production methods.
A Conflictological Interpretation of the Concept of Derisking US-Chinese Trade Relations
Authors: Musaev A. I. , Ahmed Z. M. S. , Shihiev Z. F. 
Published: July 2024

In this article, authors critically analyze the concept of derisking. Derisking is actively promoted by the Western expert community as a new strategic basis for US-China trade relations. Derisking refers to the transition from the policy of radical breakdown from the trade partnership with China to the rhetoric of risk reduction, which implies limiting dependencies and risks arising from them. It does not imply a complete rupture with a partner. Based on the extensive historical material study, as well as applying modern conflictological methods of risk analysis, authors come to the conclusion that derisking management strategy does not have the conceptual optics necessary for analyzing political dimension of international economic relations and is unable to explain what is the source of risks in reality.Conceptual non-viability of derisking is due to disregard for the uneven capital development regularity, which determines the interstate relations. Global economy is a space of unfading conflict within the economic competition, and therefore eternal risk activity. The constant presence of risks in international relations makes conflict either a source that generates risks, or their result. On the example of the US-China trade relations, authors demonstrate how an attempt to elevate a partner who was designated for the outsiders’ fate generates a response from the risk-beneficiary to return the outsider to his native bosom by minimizing the consequences of risk for himself at the expense of others.In fact, behind the derisking strategy, lies desire to increase the intellectual rents’ price paid for Western patents and technologies. The reaction to the possibility of losing one’s monopoly position creates an impulse to shake up relations and change their dynamics in the right direction for oneself. These impulses expose inherent systematical contradictions and determine the outbreak of a new round of a hot trade war. While staying in the negative unity relations, participants have no other choice but to achieve the goals of enrichment, which are the same for all participants, through denying each other, and aspire every time to establish unequal economic exchange in their favor.
Influence of Cash Waqf on Economic Growth Evidence from Malaysia
Authors: Ramli Mona Fairuz , Shaari Mai Syaheera M. , Bakhri Boy Syamsul 
Published: July 2024

This paper proposes to look into the connection between Malaysian economic growth and cash waqf. This research makes use of time series data from the World Bank’s development indicators covering the years 2013 to 2019. To analyse both the long-term as well as short-term relationships between Malaysia’s cash waqf and the country’s economic growth, this research used the Autoregressive Distributed Lag (ARDL) model for cointegration and the Error Correction Model (ECM). Furthermore, the data indicates that while cash waqf has a short-term negative impact on economic growth, it possesses a favourable long-term impact from 2013 to 2019. Cash waqf is gradually becoming a tool for improving social well-being, lowering poverty rates and assisting in economic growth in the long run. Hence, the results portray a strong government supporting the importance of strengthening the waqf distribution policy to improve economic growth by raising awareness among financial institutions about the importance of philanthropy in cash waqf management and distribution. The ARDL model for cointegration and the ECM are used to assess both short- and long-run relationships in this research to add to the body of knowledge with regard to economic growth and cash waqf in Malaysia.
Citotoxicidad de la ocratoxina A sobre la propagación celular de HepG2
Authors: Contreras Altahona Francisco J , Jaimes Méndez Nancy , Gil Durán Manuel Alejandro , Rojas Contreras Olga Liliana 
Published: July 2024

La ocratoxina A (OTA) es un metabolito secundario producido por hongos de los géneros Aspergillus y Penicillum, con efecto tóxico para diversos seres vivos, se encuentra en una gran diversidad de alimentos y piensos para animales, por esta razón radica la importancia de estimar los efectos tóxicos de la OTA en la línea celular HepG2 mediante la inhibición de la proliferación celular y determinar los cambios morfológicos en las células y su correlación con la apoptosis. La línea celular HepG2 se expuso durante 48 y 72 horas a concentraciones de 1,0; 2,5; 10 y 15 µM de OTA liofilizada; a continuación, la actividad antiproliferativa de la micotoxina se calculó aplicando el método colorimétrico MTT (bromuro de 3-(4,5-dimetil-2-tiazolil)-2,5-difeniltetrazolio). Posteriormente, en células HepG2 tratadas con 10µM de OTA por 48 horas se analizaron los cambios morfológicos relacionados con la muerte celular apoptótica por microscopia electrónica de transmisión. La propagación de las células HepG2 se afecta desde la concentración de 2,5µM de OTA, en contraste con el control. Después, se realizó la medición de la concentración inhibitoria media (CI50) de OTA sobre las células HepG2, esta fue de 9,19µM DE±0,68 y de 9,98µM DE±0,4, a las 48 y 72 horas, respectivamente. Se evidenciaron alteraciones morfológicas relacionadas con la muerte celular por apoptosis en las células HepG2, como la fragmentación del núcleo (cariorrexis), fragmentación celular y formación de los cuerpos apoptóticos.
Barcelona Declaration on Open Research Information: A significant milestone for the development of open science
Authors: Kochetkov D. M. 
Published: July 2024

The information environment of scientific research requires fundamental changes. Decisionmaking and research assessment cannot be based on opaque and non-inclusive information anymore. The signatories of the Barcelona Declaration on Open Research Information have taken responsibility for transforming how research information is created and used. Openness of information should become a new standard in science. This introduction aims to provide a brief overview of the Barcelona Declaration, including its context, aims, motivations, and potential challenges for implementation.