bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplemental Material: Spatial–temporal variations in Mesozoic crustal thickness along the northeast Asian continental margin: Response to the subduction history of the Paleo-Pacific Plate
Authors: Tang Jie , al. et 
Published: June 2024

<p>Table S1: The compositions and predicted crustal thickness of the Mesozoic magmatic rocks in the northeast Asian continental margin. Table S2: The Cu-Mo-Au deposits in the northeast Asian continental margin. </p>
Laryngeal stridor in children caused by reversible metabolic disease
Authors: Alnemari Farah Salman , Alsheef Hussain , Almalki Zohour Awadh 
Published: June 2024

We report a case of a boy in his middle childhood who presented with inspiratory stridor and lactic acidosis and was subsequently diagnosed with partial biotinidase deficiency. Fibreoptic laryngoscope showed paradoxical vocal fold mobility.Partial biotidinase deficiency is an inherited disorder in which the body is unable to recycle the vitamin biotin. It may result in clinical consequences and can be easily treated with biotin but need a high index of suspicion to diagnose. The main symptoms include ataxia, seizures, hypotonia, psychomotor retardation, alopecia, skin rash, progressive deafness, optic atrophy and life-threatening episodes of metabolic acidosis. Laryngeal stridor is an uncommon presentation, but it is reversible in case of biotinidase deficiency. Invasive procedure like tracheostomy has not been shown to enhance outcomes.
Quantum gravity modifications to the accretion onto a Kerr black hole
Authors: Sánchez Luis A. 
Published: June 2024

AbstractIn the framework of the Asymptotic Safety scenario for quantum gravity, we analyze quantum gravity modifications to the thermal characteristics of a thin accretion disk spiraling around a renormalization group improved (RGI-) Kerr black hole in the low energy regime. We focused on the quantum effects on the location of the innermost stable circular orbit (ISCO), the energy flux from the disk, the disk temperature, the observed redshifted luminosity, and the accretion efficiency. The deviations from the classical general relativity due to quantum effects are described for a free parameter that arises in the improved Kerr metric as a consequence of the fact that the Newton constant turns into a running coupling G(r) depending on the energy scale. We find that, both for rapid and slow rotating black holes with accretion disks in prograde and retrograde circulation, increases in the value of this parameter are accompanied by a decreasing of the ISCO, by a lifting of the peaks of the radiation properties of the disk and by an increase of the accretion mass efficiency, as compared with the predictions of general relativity. Our results confirm previously established findings in Zuluaga and Sánchez (Eur Phys J C 81:840, 2021) where we showed that these quantum gravity effects also occur for an accretion disk around a RGI-Schwarzschild black hole.
Machine learning the breakdown of tame effective theories
Authors: Lanza Stefano 
Published: June 2024

AbstractEffective field theories endowed with a nontrivial moduli space may be broken down by several, distinct effects as the energy scales that are probed increase. These may include the appearance of a finite number of new states, or the emergence of an infinite tower of states, as predicted by the Distance Conjecture. Consequently, the moduli space can be partitioned according to which kind of state first breaks down the effective description, and the effective-theory cutoff has to be regarded as a function of the moduli that may abruptly vary in form across the components of the partition. In this work we characterize such a slicing of the moduli space, induced by the diverse breakdown mechanisms, in a two-fold way. Firstly, employing the recently formulated Tameness Conjecture, we show that the partition of the moduli space so constructed is composed only of a finite number of distinct components. Secondly, we illustrate how this partition can be concretely constructed by means of supervised machine learning techniques, with minimal bottom-up information.
Revisiting inert doublet model parameters
Authors: Abouabid Hamza , Arhrib Abdesslam , Hmissou Ayoub , Rahili Larbi 
Published: June 2024

AbstractIn this study, we aim to see how much the actual measurement of the Z+photon and di-photon signal strength, $$\mu _{\gamma \gamma }$$

μ

γ
γ

and $$\mu _{\gamma Z}$$

μ

γ
Z

, could influence the allowed parameter space of the Inert Doublet Model (IDM), and to what extent such measurement can be aligned with the latest bound from XenonNT experiment on the spin-independent dark-matter-nucleon scattering cross-section. Also, by considering the new embedded scalars in the IDM (i.e., S, A and $$H^\pm $$

H
±

), a wide investigation of the one-loop radiative corrections to the trilinear Higgs coupling hhh has been made in the light of the previous measurements.
Advancing tribological simulations of carbon-based lubricants with active learning and machine learning molecular dynamics
Authors: Pacini Alberto , Ferrario Mauro , Loehle Sophie , Righi M. Clelia 
Published: June 2024

AbstractThe need to move toward more sustainable lubricant materials has sparked an ever growing interest on the tribological performances of additives based on environmentally friendly molecules, such as carbon-based compounds, and green liquid media as aqueous solutions. The prediction of the solubility of the additives into the liquid and the tribochemistry of decomposition and polymerization of the additive molecules under harsh conditions is essential for understanding the atomistic mechanisms leading to the formation in situ of the carbon-based lubricious tribofilms so effective in reducing friction and wear at solid interfaces. To this extent, the application of tools like ab initio molecular dynamics based on first-principle density functional theory is severely hindered by the size of the systems of interests and the need to simulate their dynamics over relatively long times. To enable tribological simulations with quantum accuracy for a first time, we develop a workflow for smart configuration sampling in active learning, to obtain machine learning interatomic potentials which are shown to be sufficiently robust and accurate also in the characteristic harsh conditions generated by high loads and shear rates. Focusing on glycerol rich lubricants, we apply this active learning strategy to generate a neural network potential to simulate the formation and behavior of nanometer thick molecular tribofilms. The simulations reveal the superior accuracy of the machine learning approach with respect to classical molecular dynamics with reactive force fields, and pave the way for more promising in depth exploration of novel carbon-based lubricants.
Case 330
Authors: Zulfiqar Maria , Al Khafaji Fatima , Wasson Megan 
Published: June 2024

History A 30-year-old female patient with a history of infertility and no pregnancy presented to the gynecologic endometriosis clinic for follow-up 1 month after oocyte retrieval, to be evaluated for pelvic optimization before potential embryo transfer, with worsening dysmenorrhea, dyspareunia, and overall pelvic pain. Eleven years prior, the patient had undergone left ovarian cystectomy for treatment of endometrioma, as well as excision of deep infiltrative endometriosis. The oocyte retrieval procedure, where more than 30 eggs were retrieved, was complicated by ovarian hyperstimulation syndrome and intraperitoneal bleeding, which necessitated admission to the intensive care unit (ICU) for 3 days. Following discharge from the ICU, the patient experienced occasional on-and-off pressure of the urinary bladder and persistent aching pelvic pain. At the 1-month follow-up appointment, the patient’s vital signs were assessed (blood pressure, 142/94 mm Hg; pulse rate, 95 per minute; temperature, 96.8 °F [36 °C]). Routine blood investigations, including white blood cell count, were within normal limits. Physical examination showed the abdomen was soft but there was mild pelvic tenderness. The serum β–human chorionic gonadotropin test result was negative for pregnancy, and urinalysis testing showed no leukocyte esterase or nitrites. MRI of the pelvis ( Figs 1 – 3 ) was performed to evaluate the worsening pain.
Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G. 
Published: June 2024

Abstract
Acute lymphoblastic leukemia expressing the gamma delta T-cell receptor (γδ T-ALL) is a poorly understood disease. We studied 200 children with γδ T-ALL from 13 clinical study groups to understand the clinical and genetic features of this disease. We found age and genetic drivers were significantly associated with outcome. γδ T-ALL diagnosed in children under 3 years of age was extremely high-risk and enriched for genetic alterations that result in both LMO2 activation and STAG2 inactivation. Mechanistically, using patient samples and isogenic cell lines, we show that inactivation of STAG2 profoundly perturbs chromatin organization by altering enhancer–promoter looping, resulting in deregulation of gene expression associated with T-cell differentiation. High-throughput drug screening identified a vulnerability in DNA repair pathways arising from STAG2 inactivation, which can be targeted by poly(ADP-ribose) polymerase inhibition. These data provide a diagnostic framework for classification and risk stratification of pediatric γδ T-ALL.
Significance: Patients with acute lymphoblastic leukemia expressing the gamma delta T-cell receptor under 3 years old or measurable residual disease ≥1% at end of induction showed dismal outcomes and should be classified as having high-risk disease. The STAG2/LMO2 subtype was enriched in this very young age group. STAG2 inactivation may perturb chromatin conformation and cell differentiation and confer vulnerability to poly(ADP-ribose) polymerase inhibition.
High levels of anxiety and depression in women farmers from Ecuador: A cross-section study in Coastal and Highlands regions
Authors: Siteneski Aline , Gómez Mieles Viviana Septimia , Romero Riaño Paola Andrea , Montes Escobar Karime , Lapo-Talledo German Josuet , Dueñas-Rodriguez Andrea Valeria , Palma Cedeño María Antonieta , Villacis Lascano Yliana Consuelo , Echeverria Zurita Lincon Oliver 
Published: June 2024

Background: Previous studies have shown that women farmers are particularly vulnerable to mental health disorders such as depression and anxiety. Aims: This study aimed to investigate the prevalence of anxiety and depression in women farmers from Ecuador Coastal and Highlands regions. Method: General Anxiety Disorder‑7 (GAD‑7) and Patient Health Questionnaire‑9 (PHQ‑9) were applied. In addition, self-reported number of children, days off, hours of work, pesticide use, sleep habits and years of work in agriculture, were also collected. This cross-sectional study occurred during 2023 with 443 women, for Coastal (197) and Highlands (246), respectively. Multivariable binary logistic regression models were performed to obtained adjusted odds ratios (aOR) and their 95% confidence intervals (95% CI). Results: 34.5% of Coastal women had depression, while 27.2% of Highlands women had depression. 20.3% of coastal women farmers had anxiety, while in the Highlands 24.8% had anxiety. Coastal mestizo and montubio women exhibited lower probability of depression, but this was not significant in the Highlands. Coastal women farmers that did not have children showed lower odds of depression (aOR 0.05, 95% CI [0.01, 0.34]). A lower likelihood of depression was observed in coastal women that worked more than 8 hours (aOR 0.22, 95% CI [0.07, 0.72]). Women from the Highlands that had shortened sleep duration exhibited lower odds of depression and anxiety. Conclusions: A higher proportion of depressed women farmers was observed in the Coast region and slightly higher numbers of anxiety cases in the Highlands. The number of children may cause workload and is correlated with depression in Coastal women.
Views on advance care planning of family members of older adults with Turkish and Moroccan backgrounds: An exploratory interview study
Authors: Demirkapu Hakki , Edally Wael , De Vleminck Aline , Van den Block Lieve , De Maesschalck Stéphanie , Devroey Dirk 
Published: June 2024

Background: Significantly fewer individuals with migration backgrounds than native-born individuals undertake advance care planning. Older adults with Turkish and Moroccan backgrounds represent one of the largest ageing non-Western minority groups in Europe. Their relatives could play important roles in facilitating or hindering advance care planning, but their views remain underexplored. Aim: To explore advance care planning knowledge, experience, views, facilitators and barriers among older Turkish and Moroccan adults’ relatives in Belgium. Design: Qualitative thematic analysis of semi-structured interview data. Setting/participants: Twenty-two relatives of older Turkish and Moroccan adults in Brussels, Mechelen and Antwerp, recruited via general practitioners. Results: Participants had limited advance care planning knowledge and had not discussed it with healthcare professionals. Some found discussing end-of-life preferences with relatives beneficial; others opposed the discussion of specific topics or felt discussions were unnecessary, as they felt responsible for caregiving and trusted by their relatives to make future decisions. Barriers included personal and relational characteristics, emotional difficulty and perceived non-urgency. Facilitators included information in older adults’ native languages, general practitioners’ cautious initiation and the involvement of several family members. Conclusions: Relatives of older people with Turkish and Moroccan backgrounds are unfamiliar with advance care planning and have highly variable views on it. People should be given opportunities to discuss advance care planning in a culturally appropriate manner, and the diversity of perspectives regarding whether and how to engage in such planning should be recognised. ClinicalTrials.gov no. NCT05241301.
The emergence and organizational choices of patient advocacy associations: Evidence from the Italian context
Authors: Morandi Federica , Di Brino Eugenio , Cicchetti Americo 
Published: June 2024

Background Within many advanced healthcare systems, patient advocacy associations are gaining a more relevant role in healthcare policy decisions. These associations provide help, representation, and voice to patients and citizens. However, although their role is important, a paucity of research exists analyzing their foundation dynamics, including their organizational decision, from a managerial perspective. To fill this knowledge gap, we formulated two research questions to investigate the motivations underlying the foundation of patient advocacy associations and the institutional pressures influencing the changes that have occurred in these associations throughout their evolution. Methods Using a semi-structured questionnaire developed as part of a larger research project, we collected data about 31 patient advocacy associations operating within the Italian National Health Service. We employed qualitative analysis to examine the associations’ birth and evolution as well as the motivations and influences driving change within the sampled organizations. Results Questionnaire responses provided information about the patient advocacy associations’ histories and highlighted their close links with the Italian National Health Service. Our results indicated the motivations for the associations’ establishment could be grouped into five categories: support at the system level, patient protection and support, actions to increase awareness, actions for improving patients’ health and quality of life, and dissemination of knowledge. We also identified the frequency and nature of the changes within the associations and explored the institutional pressures that influenced these organizational changes. Conclusions The results can be interpreted considering the organizational theories that focus on organizations’ establishment decisions and how external pressures impact organizations’ dynamics and evolution.
Loss of control of herpes suppression following bariatric surgery
Authors: Samraj Shyam , Olasoji Kimberley , Patel Raj 
Published: June 2024

We report a 42-year-old female with confirmed recurrent genital herpes (HSV-2), which was well controlled on suppressive antiviral therapy with aciclovir 400 mg twice daily. The patient required bariatric surgery in order to manage what was deemed a dangerously high BMI. A Roux-en-Y procedure was performed which effectively reduced her weight; however, herpes suppression become ineffective post operatively, with serious herpes related complications, despite increasing the total dose of aciclovir and the frequency from twice daily to three times a day. Complete herpes control was restored by changing therapy to valaciclovir 500 mg twice daily. The Roux-en-Y procedure is the most common form of bariatric surgery. Consequences on the efficacy of different herpes antivirals can be predicted from what is known of their properties and sites of absorption. Similar problems with herpes virus suppression may be avoided by an anticipated change in therapy preoperatively.
Study on UPLC–MS/MS Method for Four Compositions of Cangzhu
Authors: Qiyong Ren , Jikai Sun , Lili Qin , Min Zhang , Junying Ma , Jun Liu , Honglian Zhang 
Published: June 2024

Background The legal quality control of Cangzhu is used the single component as an evaluation indicator, which would not be enough to reflect the authenticity of quality. It is necessary to select several typical chemical components as the basis for quality control of medicinal materials and decoction pieces to reflect the content of effective ingredients. Purpose Based on UPLC-MS/MS, the study aimed to build the content determination method of atractyloidin, atractylidin A, atractylenolide I, and atractylenolide III in Cangzhu from different sources. Materials and Methods Agilent SB-C18 (2.1 × 100 µm, 1.8 µm) was used to be the stationary phase. The mobile phase system was formed by water-formic acid (1000:1) and acetonitrile-formic acid (1000:1) in gradient elution. The column temperature set at 40℃, and the flow rate was 0.3 mL min–1. Results The contents of atractyloidin, atractylidin A, atractylenolide I, and atractylenolide III had good linearity in a certain range (r2 ≥ 0. 9990). The RSD of the precision, stability and repetitive test results were less than 3.00%. In addition, the content of the four components were some different among different patches of Cangzhu. Conclusion The method was simple, rapid and highly sensitive, which was suitable for the determination of atractyloidin, atractylidin A, atractylenolide I, and atractylenolide III in Cangzhu.
ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies
Authors: Elitzur Sarah , Shiloh Ruth , Loeffen Jan L. C. , Pastorczak Agata , Takagi Masatoshi , Bomken Simon , Baruchel Andre , Lehrnbecher Thomas , Tasian Sarah K. , Abla Oussama , Arad-Cohen Nira , Astigarraga Itziar , Ben-Harosh Miriam , Bodmer Nicole , Brozou Triantafyllia , Ceppi Francesco , Chugaeva Liliia , Dalla Pozza Luciano , Ducassou Stephane , Escherich Gabriele , Farah Roula , Gibson Amber , Hasle Henrik , Hoveyan Julieta , Jacoby Elad , Jazbec Janez , Junk Stefanie , Kolenova Alexandra , Lazic Jelena , Lo Nigro Luca , Mahlaoui Nizar , Miller Lane , Papadakis Vassilios , Pecheux Lucie , Pillon Marta , Sarouk Ifat , Stary Jan , Stiakaki Eftichia , Strullu Marion , Tran Thai Hoa , Ussowicz Marek , Verdu-Amoros Jaime , Wakulinska Anna , Zawitkowska Joanna , Stoppa-Lyonnet Dominique , Taylor A. Malcolm , Shiloh Yosef , Izraeli Shai , Minard-Colin Veronique , Schmiegelow Kjeld , Nirel Ronit , Attarbaschi Andishe , Borkhardt Arndt 
Published: June 2024

Abstract
Ataxia-telangiectasia (A-T) is an autosomal-recessive disorder caused by pathogenic variants (PVs) of the ATM gene, predisposing children to hematological malignancies. We investigated their characteristics and outcomes to generate data-based treatment recommendations. In this multinational, observational study we report 202 patients aged ≤25 years with A-T and hematological malignancies from 25 countries. Ninety-one patients (45%) presented with mature B-cell lymphomas, 82 (41%) with acute lymphoblastic leukemia/lymphoma, 21 (10%) with Hodgkin lymphoma and 8 (4%) with other hematological malignancies. Four-year overall survival and event-free survival (EFS) were 50.8% (95% confidence interval [CI], 43.6-59.1) and 47.9% (95% CI 40.8-56.2), respectively. Cure rates have not significantly improved over the last four decades (P = .76). The major cause of treatment failure was treatment-related mortality (TRM) with a four-year cumulative incidence of 25.9% (95% CI, 19.5-32.4). Germ line ATM PVs were categorized as null or hypomorphic and patients with available genetic data (n = 110) were classified as having absent (n = 81) or residual (n = 29) ATM kinase activity. Four-year EFS was 39.4% (95% CI, 29-53.3) vs 78.7% (95% CI, 63.7-97.2), (P &lt; .001), and TRM rates were 37.6% (95% CI, 26.4-48.7) vs 4.0% (95% CI, 0-11.8), (P = .017), for those with absent and residual ATM kinase activity, respectively. Absence of ATM kinase activity was independently associated with decreased EFS (HR = 0.362, 95% CI, 0.16-0.82; P = .009) and increased TRM (hazard ratio [HR] = 14.11, 95% CI, 1.36-146.31; P = .029). Patients with A-T and leukemia/lymphoma may benefit from deescalated therapy for patients with absent ATM kinase activity and near-standard therapy regimens for those with residual kinase activity.