bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three‐Dimensional Porous Heterometallic‐Organic Frameworks: Synthesis, Luminescent, Magnetic, Adsorption and Hydrogen Storage Properties
Authors: Cao Yaqun , Wang Runwei , Wu Gang , Fang Qianrong , Qiu Shilun 
Published: November 2015

AbstractTwo three‐dimensional (3D) porous heterometal‐organic frameworks (HMOFs) with isostructures, [Zn2Cd(OH)(BTC)2(DMF)(H2O)2]·(H3O) (JUC‐155A) and [ZnCo2(OH)(BTC)2(DMF)(H2O)2]·(H3O) (JUC‐155B) (JUC=Jilin University China, BTC=1,3,5‐benzenetricarboxylate and DMF=N,N‐dimethylformamide), have been successfully synthesized by utilizing two kinds of 3d metal ions (Zn(II) and Cd(II) or Zn(II) and Co(II)) under conformable conditions. X‐ray crystallography reveals that both HMOFs consist of trinuclear metal‐carboxylate secondary building units (SBUs), and these SBUs are interlinked by the phenyl groups of BTC ligands to generate 3D open‐frameworks with two types of channels of about 6.3 and 10.7 Å. Both HMOFs show the multifunctional properties in photoluminescence and adsorption. JUC‐155B also exhibits an antiferromagnetic interaction, owing to the presence of dinuclear cobalt centers. Additionally, the high‐pressure hydrogen storage of JUC‐155A has been also examined at 77 K. By using mixed metal centers in clustered SBUs, it is a good strategy to construct those isostructures with heterometallic systems, and it is believed that the presence of such HMOFs will further facilitate the exploration of multifunctional materials.
An Efficient Copper‐Catalyzed One‐Pot Synthesis of 1‐Aryl‐1,2,3‐triazoles from Arylboronic Acids in Water under Mild Conditions
Authors: Hao Changbo , Zhou Changjian , Xie Jianwei , Zhang Jie , Liu Ping , Dai Bin 
Published: November 2015

AbstractA convenient method for one‐pot two‐step 1,3‐dipolar cycloadditon reaction of arylboronic acid, sodium azide followed with terminal alkynes in the presence of 2‐pyrrolecarbaldiminato‐Cu(II) complexes catalyst is reported. Various 1‐aryl‐1,2,3‐triazoles were prepared in 63%–97% yields in water at 30°C without any additives and avoiding the isolation of unstable aryl azides.
Three Dimensional Sulfur‐doped Graphene Hydrogels with Tetrathiafulvalene for High Performance Supercapacitors
Authors: Zhang Jingli , Jiang Man , Xing Lingbao , Qin Kun , Liu Tianzhen , Zhou Jin , Si Weijiang , Cui Hongyou , Zhuo Shuping 
Published: November 2015

AbstractBy using tetrathiafulvalene as reducing and doping agents, three‐dimensional (3D) sulfur‐doped graphene hydrogels (SGHs) were facilely prepared in mixed solvents of dimethyl formamide and water. Several investigations reveal that TTF plays a critical role in the formation of such unique 3D architecture, as it not only reduces GO to self‐assembly into 3D structures, but also can be transformed to TTF·+ and TTF2+ as doping agents in the reduction process. The morphology, crystal structure, chemical bonding, elemental composition and porosity of the as‐prepared SGHs have been studied. Benefiting from well‐defined and cross‐linked 3D porous network architectures, the supercapacitors based on the SGHs in KOH electrolyte exhibited a high specific capacitance of 212.5 F·g−1 at 0.3 A·g−1. Furthermore, this capacitance also showed good electrochemical stability and a high degree of reversibility in the repetitive charge/discharge cycling test.
Impact of access to NCI‐ and NCCN‐designated cancer centers on outcomes for multiple myeloma patients: A SEER registry analysis
Authors: Ailawadhi Sikander , Advani Pooja , Yang Dongyun , Ghosh Radhika , Swaika Abhisek , Roy Vivek , Foran James , Colon‐Otero Gerardo , Chanan‐Khan Asher 
Published: November 2015

BACKGROUNDNational Cancer Institute (NCI)/National Comprehensive Cancer Network (NCCN)–designated cancer centers (CCs) offer patients state‐of‐the‐art treatment, but their impact on multiple myeloma (MM) patient outcomes has not been evaluated.METHODSAdult MM patients diagnosed between 1973 and 2011 were identified from the Surveillance, Epidemiology, and End Results database and were stratified by the county of residence at the time of diagnosis and the year of CC designation. The influence of NCI/NCCN CC access, race, and the year of diagnosis on overall survival (OS) was evaluated with a Cox regression model.RESULTSA statistically significant OS improvement was noted in patients diagnosed after 1995 with access to 2 or more NCI CCs overall (P = .002 for 1996‐2002; P < .001 for 2003‐2011) and by race for whites (hazard ratio [HR] for 1996‐2002, 0.85; 95% confidence interval [CI], 0.78‐0.91; HR for 2003‐2011, 0.85; 95% CI, 0.79‐0.91) but not for nonwhites. For NCCN access, improvement was seen in 1996‐2002 (P = .003), in 2003‐2011 (P < .001), and by race for whites (HR, 0.917; 95% CI, 0.88‐0.95) and nonwhites (0.94; 95% CI, 0.89‐0.99), but within nonwhites, this was true only for African Americans (AAs; HR, 0.88; 95% CI, 0.81‐0.97) and not for Asians, Hispanics, or Native Americans.CONCLUSIONSImprovement in OS was seen in MM patients diagnosed after 1995 with access to 1 NCCN CC or 2 or more NCI CCs. NCI access benefited only whites, whereas NCCN access benefited only white and AA patients. No OS benefit was seen for any subgroup with access to only 1 NCI center. Eliminating racial disparities in health care access and utilization is needed to improve outcomes. Cancer 2016;122:618–625. © 2015 American Cancer Society.
Impact of oncogene rearrangement patterns on outcomes in patients with double‐hit non‐Hodgkin lymphoma
Authors: Landsburg Daniel J. , Petrich Adam M. , Abramson Jeremy S. , Sohani Aliyah R. , Press Oliver , Cassaday Ryan , Chavez Julio C. , Song Kevin , Zelenetz Andrew D. , Gandhi Mitul , Shah Namrata , Fenske Timothy S. , Jaso Jesse , Medeiros L. Jeffrey , Yang David T. , Nabhan Chadi 
Published: November 2015

BACKGROUNDDouble‐hit lymphomas (DHLs) are collectively defined as B‐cell non‐Hodgkin lymphomas harboring rearrangements of MYC as well as B‐cell lymphoma 2 (BCL2) and/or B‐cell lymphoma 6 (BCL6). To the authors' knowledge, the impact of specific oncogene rearrangements on outcomes of patients with DHL who are treated with immunochemotherapy has not been previously described.METHODSThe authors identified patients whose diagnostic tissue specimens underwent metaphase karyotyping or fluorescence in situ hybridization for MYC as well as both BCL2 and BCL6 rearrangements. Cohorts were defined by the presence (+) or absence (−) of rearrangements: MYC+/BCL2+/BCL6− (BCL2‐DHL), MYC+/BCL2−/BCL6+ (BCL6‐DHL), and MYC+/BCL2+/BCL6+ (triple‐hit lymphoma; THL).RESULTSA total of 117 patients were included in the current analysis (76 BCL2‐DHL patients, 16 BCL6‐DHL patients, and 25 THL patients). Compared with patients with BCL2‐DHL, those with BCL6‐DHL were more likely to be classified as having a non‐germinal center cell of origin, presented with extranodal disease, and appeared to achieve higher rates of complete response despite receiving intensive induction therapy less frequently. However, patients with BCL6‐DHL experienced a shorter median overall survival if achieving an initial complete response compared with patients with BCL2‐DHL. Patients with THL experienced survival outcomes similar to those of patients with BCL2‐DHL.CONCLUSIONSRecognition of the specific oncogene rearrangements may be of prognostic value and potentially guide future therapeutic strategies for patients with DHL. Cancer 2016;122:559–564. © 2015 American Cancer Society.
Integrating Apache Airavata with Docker, Marathon, and Mesos
Authors: Saha Pankaj , Govindaraju Madhusudhan , Marru Suresh , Pierce Marlon 
Published: November 2015

SummaryScience Gateways provide scientists with tools for creating, executing, and monitoring scientific experiments on multiple resource infrastructures. Apache Airavata abstracts interactions between gateways and distributed computing infrastructures like Extreme Science and Engineering Discovery Environment, international grids, and campus clusters. Airavata consists of several component services such as the API server, Orchestrator, Workflow Interpreter, Credential Store, and Application Factory. In addition, Airavata uses third party software, including RabbbitMQ for messaging, MySQL for production database management, and Apache Zookeeper for internal communications. In this paper, we discuss our initial experiences with leveraging open source technologies to manage Airavata and its dependent components to deploy, detect, and restart failed components in an auto‐scaling platform. Such capabilities will allow Airavata services to be deployed in a wide area, large Virtual Machine (VM) based cluster, and a developer's laptop. The emerging technologies in cloud computing and Big Data that address these needs are the following: Docker, Marathon, and Apache Mesos. Docker is a Linux‐based lightweight container that allows different applications to run isolated from each other but safely share the machine's resources. Docker images of applications can be published in registries and retrieved for execution in the target infrastructures. Marathon provides a cluster‐wide init and control system for services, including Docker containers. Mesos provides a cluster‐wide framework to schedule tasks based on fine‐grained resource needs. Mesosphere provides the packages, scripts, and web interface to ease the use of these technologies. We present the design, experience, and lessons learned from integrating Mesos, Docker, and Marathon with Apache Airavata. Copyright © 2015 John Wiley & Sons, Ltd.
Carbon Dioxide Sequestration by Using a Model Carbonic Anhydrase Complex in Tertiary Amine Medium
Authors: Sivanesan Dharmalingam , Choi Youngju , Lee Jiyeon , Youn Min Hye , Park Ki Tae , Grace Andrew Nirmala , Kim Hak‐Joo , Jeong Soon Kwan 
Published: November 2015

AbstractGlobally, the elevation of carbon dioxide (CO2) levels due to the anthropogenic effect poses a serious threat to the ecosystem. Hence, it is important to control and/or mitigate the level of CO2 in the atmosphere, which necessitates novel tools. Herein, it is proposed to improve CO2 sequestration by using model complexes based on the enzyme carbonic anhydrase (CA) in aqueous tertiary amine medium. The effect of substituents on the model CA model complexes on CO2 absorption and desorption was determined by using a stopped‐flow spectrophotometer to follow pH changes through coupling to pH indicator and a continuous stirred‐tank reactor (CSTR). The CO2 hydration rate constants were determined under basic conditions and compound 6, which contained a hydrophilic group, showed the highest absorption or hydration levels of CO2 (2.860×103 L mol−1 s−1). In addition, CSTR results for the absorption and desorption of CO2 suggest that simple model CA complexes could be used in post‐combustion processing.
Design of a Data‐Oriented Multivariable PID Control System
Authors: HAYASHI KAYOKO , YAMAMOTO TORU 
Published: November 2015

SUMMARYPID control schemes have been widely employed for industrial processes. However, it is important to choose a suitable set of PID gains included in the PID controller, because the control performance strongly depends on these PID gains. For single‐input/single‐output systems, data‐oriented control schemes without using the system model in computing PID gains have been proposed. In this paper, the proposed scheme is extended to a multi‐input/multi‐output case. That is, PID gains included in the multivariable PID controllers can be derived by using only the operating data. As a result, the suitable set of PID gains can be obtained, and it enables the system output to track to the reference model output. The behavior of the proposed scheme is examined by numerical simulation examples.
Enlargement of Claw Pole Motor Using SMC Cores Divided in the Circumferential Direction
Authors: KOKA HIDETOSHI , NAGANUMA RYOICHI , ENOMOTO YUJI , KITAMURA MASASHI , KIKUCHI SATOSHI 
Published: November 2015

SUMMARYClawtooth motors have the feature that they can be made thin in the axial direction. This makes them suitable for appliances, automobile accessories, and small‐sized industrial motors. On the other hand, there is a need for thinner HEV and elevator motors and large‐sized industrial motors. In this study, we examined ways of increasing the output of clawtooth motors. We arrived at the following conclusions. (1) The optimal stator structure was determined and the prospects of attaining the target specification of 123 N‐m were determined. (2) Three important manufacturing tasks, assurance of core assembly accuracy, thin coil manufacture, and rotator insertion, were identified. (3) Experimental results and the results of analysis were in agreement with respect to the EMF. (4) The experimental cogging torque results and finite element analysis (FEA) results were in agreement with the FEA results at sixth order but not at second and fourth order. (5) Although the core needed to be divided in the circumferential direction in order to increase its size, it was clear that the influence on the torque was small. (6) Use of a divided core is a good solution for enlargement of clawtooth motors.
Improved Modified Switching Transient Pulse Width Modulation (MT‐PWM) Method Applied to H‐Bridge Type Step‐Down Converter
Authors: MORI TAKAO , FUNATO HIROHITO , OGASAWARA SATOSHI , OKAZAKI FUMIHIRO , HIROTA YUKITSUGU 
Published: November 2015

SUMMARYThe authors have devised a new method to decrease high‐frequency harmonics in a specific frequency band by modifying the switching transient slope. In previous studies, there were several problems in applying modified transient pulse width modulation (MT‐PWM) to actual converters. In this paper, three problems are solved using an improved MT‐PWM method. First, the MT‐PWM signal was obtained using a trial‐and‐error approach that involved complex computation procedures in the previous studies. In this paper, a new calculation procedure for obtaining the MT‐PWM waveform using a simple calculation is proposed. Second, a new controller (drain‐source voltage controller) based on voltage feedback is proposed in order to realize a modified switching transient to increase the stability of the switching operation. Third, the dependency of MT‐PWM on source voltage variation is investigated in order to implement MT‐PWM in an actual step‐down converter. From this result, the concept of a new type of controller with the source voltage variation taken into consideration is proposed. Finally, the authors attempted to apply MT‐PWM to an H‐bridge converter to expand the application of MT‐PWM. An H‐bridge converter with MT‐PWM for a dc motor drive is successfully operated in an experiment.
Total Synthesis of [14C]‐Labelled Homoharringtonine
Authors: Marguerit Melanie , Little Gill , Wang Yi , He Linli , Allwein Shawn , Reif James , Rossi Jason , Roemmele Renee , Bakale Roger 
Published: November 2015

AbstractA total synthesis of enantiomerically pure [14C]‐labelled (–)‐homoharringtonine in 17 steps is reported. This synthetic process enabled the production of Good Manufacturing Practice (GMP) compliant (–)‐[14C]homoharringtonine that was used in a human mass balance study that was a post‐approval commitment to the U.S. Food and Drug Administration. (–)‐Homoharringtonine, also called omacetaxine mepesuccinate, is approved to treat adult patients with chronic myeloid leukemia (CML), a blood and bone marrow disease. In November 2012, the product was commercialised as Synribo® in the U.S., marketed by Teva Pharmaceuticals.
BEt3‐Initiated Thiol–Ene Click Reactions as a Versatile Tool To Modify Sensitive Substrates
Authors: Gorges Jan , Kazmaier Uli 
Published: November 2015

AbstractBEt3‐initiated thiol–ene click reactions are an interesting alternative to the generally used thermal or photochemical thiol additions. The reactions proceed under very mild conditions, and require only 10 mol‐% of BEt3, and an almost stoichiometric amount of thiol. In this regard, this method is an attractive alternative to the other protocols, which often use the thiol component in a large excess.
Palladium‐Catalyzed Regio‐ and Chemo­selective Reactions of 2‐Bromobenzyl Bromides: Expanding the Scope for the Synthesis of Biaryls Fused to a Seven‐Membered Sultam
Authors: Laha Joydev K. , Sharma Shubhra , Dayal Neetu 
Published: November 2015

AbstractSpeedy access to biaryls fused to seven‐membered sultams was achieved by starting from readily accessible N‐alkylbenzenesulfonamides and 2‐bromobenzyl bromides. The protocol features a domino reaction and proceeds through an N‐benzylation followed by an intramolecular direct C–H arylation that occurs ortho to the sulfonamide group.
Correlation of Overvoltages and Current Densities to Estimate Optimal Electrode Size for Sediment Microbial Fuel Cells
Authors: Nam Jonghyeon , Lee Yoo Seok , An Junyeong , Kim Bongkyu , Lee Hyung‐Sool , Chang In Seop 
Published: November 2015

AbstractWe propose a method to determine the optimal electrode size of sediment microbial fuel cells (SMFCs). Four SMFCs presented a proportional increase in the current to the electrode size of the MFCs at day 16. From the I–V curves of the SMFCs, four plots of current versus electrode size (I–Esize plots) were obtained, which displayed high R2 values ranging from 0.980 to 0.994. At day 47, however, V–I curves deviated in one of the four MFCs, such that the I–Esize plots obtained from the I–V curves were inappropriate for estimating the electrode size. We found that the curves of overvoltage against the current density (η–j curves) were comparable in the SMFCs, suggesting that the overvoltage is inversely proportional to the electrode size of the MFCs. The I–Esize plots corrected by using the η–j curves had high R2 values of over 0.978, indicating that the η–j curves can be used for estimating the electrode size when the working voltage to current density ratio is different in SMFCs.
Nontarget effects of ivermectin residues on earthworms and springtails dwelling beneath dung of treated cattle in four countries
Authors: Scheffczyk Adam , Floate Kevin D. , Blanckenhorn Wolf U. , Düring Rolf-Alexander , Klockner Andrea , Lahr Joost , Lumaret Jean-Pierre , Salamon Jörg-Alfred , Tixier Thomas , Wohde Manuel , Römbke Jörg 
Published: November 2015

Abstract

The authorization of veterinary medicinal products requires that they be assessed for nontarget effects in the environment. Numerous field studies have assessed these effects on dung organisms. However, few studies have examined effects on soil-dwelling organisms, which might be exposed to veterinary medicinal product residues released during dung degradation. The authors compared the abundance of earthworms and springtails in soil beneath dung from untreated cattle and from cattle treated 0 d, 3 d, 7 d, 14 d, and 28 d previously with ivermectin. Study sites were located in different ecoregions in Switzerland (Continental), The Netherlands (Atlantic), France (Mediterranean), and Canada (Northern Mixed Grassland). Samples were collected using standard methods from 1 mo to 12 mo after pat deposition. Ivermectin concentrations in soil beneath dung pats ranged from 0.02 mg/kg dry weight (3 mo) to typically &lt;0.006 mg/kg dry weight (5–7 mo). Earthworms were abundant and species-rich at the Swiss and Dutch sites, less common with fewer species at the French site, and essentially absent at the Canadian site. Diverse but highly variable communities of springtails were present at all sites. Overall, results showed little effect of residues on either earthworms or springtails. The authors recommend that inclusion of soil organisms in field studies to assess the nontarget effects of veterinary medicinal products be required only if earthworms or springtails exhibit sensitivity to the product in laboratory tests. Environ Toxicol Chem 2016;35:1959–1969. © 2015 SETAC
Resting‐state functional connectivity of the striatum in early‐stage Parkinson's disease: Cognitive decline and motor symptomatology
Authors: Manza Peter , Zhang Sheng , Li Chiang‐Shan R. , Leung Hoi‐Chung 
Published: November 2015

AbstractParkinson's disease is a neurodegenerative disorder characterized by changes to dopaminergic function in the striatum and a range of cognitive and motor deficits. Neuroimaging studies have repeatedly shown differences in activation and functional connectivity patterns of the striatum between symptomatic individuals with Parkinson's disease and healthy controls. However, the presence and severity of cognitive and motor symptoms seem to differ dramatically among individuals with Parkinson's disease at the early‐stages. To investigate the neural basis of such heterogeneity, we examined the resting state functional connectivity patterns of caudate and putamen subdivisions in relation to cognitive and motor impairments among 62 early‐stage individuals with Parkinson's disease (21 females, 23 drug naive, ages 39–77 years, average UPDRS motor scores off medication = 18.56, average H&Y stage = 1.66). We also explored how changes in striatal connectivity relate to changes in symptomatology over a year. There are two main findings. First, higher motor deficit rating was associated with weaker coupling between anterior putamen and midbrain including substantia nigra. Intriguingly, steeper declines in functional connectivity between these regions were associated with greater declines in motor function over the course of 1 year. Second, decline in cognitive function, particularly in the memory and visuospatial domains, was associated with stronger coupling between the dorsal caudate and the rostral anterior cingulate cortex. These findings remained significant after controlling for age, medication, gender, and education. In sum, our findings suggest that cognitive decline and motor deficit are each associated with a differentiable pattern of functional connectivity of striatal subregions. Hum Brain Mapp 37:648–662, 2016. © 2015 Wiley Periodicals, Inc.
Identifying cutoff scores for the EORTC QLQ‐C30 and the head and neck cancer–specific module EORTC QLQ‐H&N35 representing unmet supportive care needs in patients with head and neck cancer
Authors: Jansen Femke , Snyder Claire F. , Leemans C. René , Verdonck–de Leeuw Irma M. 
Published: November 2015

AbstractBackgroundThis study investigates cutoff scores for the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30‐questions (EORTC QLQ‐C30) and head and neck cancer‐specific module (QLQ‐H&N35) to identify patients with head and neck cancer who may require clinical attention.MethodsNinety‐six patients with head and neck cancer completed the EORTC QLQ‐C30/H&N35 and questions on supportive care needs. For all EORTC domains with the ability to discriminate between patients with and without unmet needs (area under the receiver operating characteristic curve [AUC] ≥0.70), the accuracy (eg, sensitivity and specificity) of potential cutoff scores were calculated.ResultsCutoff scores (sensitivity ≥0.80 and specificity ≥0.60) of 90 (functioning domains) and 5 to 10 (symptom domains) were found on 7 of 28 continuous EORTC QLQ‐C30/H&N35 domains. Borderline cutoff scores (sensitivity ≥0.70 and specificity ≥0.60 or sensitivity ≥0.80 and specificity ≥0.50) were found on 5 other domains.ConclusionsThis study provided cutoff scores on the EORTC QLQ‐C30 and H&N35 based on patients' perceptions of their needs for supportive care. Future research is needed on the replicability of these cutoff scores. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1493–E1500, 2016