bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between PD-L1, PD-1, CD8 and Clinicopathological Factors in Primary SCCs
Authors: Vasilev Preslav , Popovska Savelina , Petrova Kraevska Elitsa , Karamanliev Martin , Dimitrov Dobromir , Yordanova Ivelina 
Published: July 2024

Introduction: Squamous cell carcinoma of the skin (SCCs) is the second most common skin cancer with continuously increasing incidence. Programmed cell death ligand 1 (PD-L1), Programmed cell death 1 receptor (PD-1) and CD8 expression in primary SCCs has not been described in many studies. Objective: We investigated the association between PD-L1, PD-1, CD8 and clinocopathological prognostic factors for recurrence, metastasis and mortality of SCCs. Patients and Methods: Immunohistochemically stained sections of 100 primary SCCs divided in two groups according to diameter of the tumors (<20 mm and >20mm) were assessed. Recombinant rabbit Anti-PD-L1 antibody [SP142] - C-terminal, rabbit monocloncal Anti-PD1 antibody [NAT105] and FLEX Mono Mo a Hu CD8, cl C8/144B, RTU were used. Results: We did not establish statistically significant differences between PD-L1, PD-1, CD8 expression and high-risk clinocopathological features – tumor size >20mm, depth >6mm, poor tumor cell differentiation, perineural/lymphovascular invasion, low/absent lymphocyte stromal reaction. Conclusions: In primary SCCs, the expression of PD-L1, PD-1 and CD8 is not associated with high-risk clinicopathological factors. We suggest that these immunohistochemical markers are more significant in advanced cases and metastatic tissues.
Nivel de conocimientos sobre diabetes y adherencia al tratamiento en los pacientes con diabetes mellitus tipo 2 de ámbito rural vs urbano
Authors: López Reyes Miguel , Peinado Ibáñez Carmen 
Published: July 2024

Objetivo principal. Evaluar la asociación entre los factores sociodemográficos y el nivel de conocimientos básicos en diabetes en los pacientes con diabetes mellitus tipo 2 (DM tipo 2). Metodología. Estudio observacional descriptivo transversal. En él determina el nivel de conocimientos sobre diabetes a través del cuestionario Diabetes Knowledge Questionnaire 24 (DKQ24) y se mide la adherencia al tratamiento a través del cuestionario Morisky Green a pacientes con DM tipo 2. Se ha tomado como muestra a 183 personas con DM tipo 2, escogiendo de forma aleatoria a 110 personas en Ciudad Real y otras 73 en Porzuna de varios cupos de enfermería. El porcentaje de pérdidas ha sido del 10%. Las mediciones se han realizado mediante cuestionarios telefónicos tras el consentimiento verbal del paciente. Resultados y Discusión. Como en otros estudios similares, la mayoría de pacientes con diabetes no llegan a los niveles adecuados de conocimientos en diabetes. Este nivel de conocimientos está asociado a la zona geográfica, nivel de estudios, realización de dieta y ejercicio diario y IMC. A pesar de ello la media de respuestas correctas ha sido más elevada que en estudios similares. La adherencia terapéutica parece guardar relación al nivel de conocimientos adecuados en diabetes, por lo que reforzar el conocimiento de los pacientes puede hacer que mejore su adherencia y prevenir complicaciones de la enfermedad.

ABSTRACT
Main objective. To evaluate the association between sociodemographic factors and the level of basic knowledge in diabetes in patients with type 2 diabetes mellitus (type 2 DM). Methodology. A cross-sectional descriptive observational study was performed. The level of knowledge about diabetes was determined through the Diabetes Knowledge Questionnaire 24 (DKQ24) and adherence to treatment is measured through the Morisky Green questionnaire in patients with type 2 DM. 183 people with type 2 DM were taken as a sample, randomly choosing 110 people in Ciudad Real and another 73 in Porzuna from various nursing vacancies. The percentage of losses has been 10%. Measurements were made using telephone questionnaires after the patient's verbal consent. Results and Discussion. As in other similar studies, the majority of patients with diabetes do not reach adequate levels of diabetes knowledge. This level of knowledge is associated with the geographical area, educational level, diet and daily exercise, and BMI. Despite this, the average number of correct answers was higher than in similar studies. Therapeutic adherence seems to be related to the level of adequate knowledge in diabetes, so reinforcing the knowledge of the patients can improve their adherence and prevent complications of the disease.
Performance of inventory turnover and sales growth on food and beverage profit of the company
Authors: Pradnyani Ni Luh Putu Lely , Astawa I Ketut , Susanto Budi , Sukmawati Ni Made Rai , Hakim Jumhur 
Published: July 2024

The study was conducted to analyse the effect of inventory turnover and sales growth on food and beverage profit at the company partially and simultaneously. This research uses a theoretical base and relevant concepts, namely the theory of inventory turnover, sales growth and food and beverage profit. This quantitative research using the analytical method namely multiple correlation analysis, classic assumption test, multiple linear regression analysis, hypothesis test (t-test, F-test, and coefficient determination), and predictor contributions. The results indicate that the t-count value of inventory turnover is smaller than t-table (0,901 < 2,035) with a significant value more than 0,05 (0,374 > 0,05). The t-countvalue of sales growth is greater than t-table (5,901 > 2,035) with a significant value less than 0,05 (0,000 < 0,05). The inventory turnover has a positive but not significant effect on food and beverage profit at The companywith a contribution of 4,576%. Sales growth has a positive and significant effect on food and beverage profit the compa ny with a contribution of 55,224%.
Influence of digital finance service worth on customer satisfaction in Nepal
Authors: Shrestha Binay , Agrawal Neha 
Published: July 2024

Customer satisfaction is a major factor to sustain competitive advantage in the present dynamic and competitive environment for the organisations. The present research work is conducted to find how customers of Nepalese banks are happy with online banking system. Primary data is collected through the questionnaire developed from SERVPERF model on 5-point Likert scale. A sample sizes of 335 total respondents taken as for data collection. The research is descriptive, causal comparative in nature. Variables included in the study are tangibles, reliability, assurance, responsiveness, empathy as exogenous variables and customer satisfaction with e-banking service quality as endogenous variable. The data analysis were performed through the techniques:- descriptive statistics, correlation, multiple regression.Results of the study showed influenceof independent variables in all categories is positive and significant on dependent with R2 value of 0.627 which means 62.7% change in endogenous variable is due to exogenous variables and rest 37.3% is due to the other factors outside the model. Study shows that customers of Nepal are appropriatelycontended with the digital banking system in Nepalese banks. Assurance have been found as highest determining factor for customer satisfaction in e-banking services in Nepal followed by reliability and empathy.
The reviews over the cases against correcting grammar for second language writing classes
Authors: Ny Sun , Doung Dara 
Published: July 2024

Writing English is a main productive process emerging from language learners of English writing both in and out the class; meanwhile, grammar correction is a ladder for their development in writing accurately. This study aimed to review the case against grammar correction. At the same time, a qualitative method was used, and the data gathering means was entirely based on secondary data. Collecting other existing research on grammar correction in writing skills was underlined, and all relevant articles and books concerning the matter were chosen and gotten through for the gist. Moreover, the elaborated results of previously operated projects were brought up for discussion. The comments, based on the raised concepts of the case against it, was augured grammar correction with theoretical evidence and were typed in as one of the new proposals. As the results showed, whether or not grammar correction or feedback in writing classes for L2 learners should be applied depends on the purposes, levels, contexts, and others; most importantly, teachers, their qualifications and professionalism are the considered facts. They have to be flexible and rich in teaching experience because it seems like a sitting-on-the-fence situation, whereas bad effects or plausible outcomes are very likely choices. This review is only document-based. Hence, empirical conductance from many corners would be an option, and thorough investigations with lots of methods should be taken into account.
Deconstructing transphobic fallacies and unveiling the realities of transgender phenomenology in India: An empirical inquiry
Authors: Basu Deblagno , Mukherjee Soumik 
Published: July 2024

The community of the trans-gendered or the gender diverse or the gender nonbinary has been the cause of many debates in recent times over their claim of equal rights of existence in India. While several first world countries have taken or are in the course of taking adequate steps to ensure their inclusion among the general masses, India despite its long history of accommodation and tolerance has fallen behind. This is largely in lieu of the prevalent discourse classifying any form of sexuality and gender that does not conform to the heteronormative gender binary as unnatural and a product of westernisation. This paper endeavours to elucidate and scrutinize the Queer and specifically Trans elements embedded within Indian Mythologies, as manifested in the Veda, Purana, Dharma-Shastra, Kama-shastra, Natyashastra, and numerous other sacred texts. By doing so, it attempts to subvert the prevailing narrative that enforces their exclusion. In addition to that, it provides a comprehensive survey of gender fluidity as depicted in Indian mythologies and ancient texts, thereby illuminating the obscured heritage of progressive advancements in gender studies within the Indian context. Moreover, it underscores the contrived essence and artificial construct of the gender binary, while emphasizing the futility of steadfastly adhering to its purported "naturalness".
Observing English classroom in the digital era
Authors: Susanto Budi , Wajdi Majid , Sariono Agus , Sudarmaningtyas Anastasia Erna Rochiyati 
Published: July 2024

Teaching and learning English for millennials requires a different approach from previous generations unfamiliar with digital technology advances. This paper tries to discuss and see how English teachers insert digital technology (WHAT) into the classroom learning process. To obtain the data for this study, the researchers observed a teacher (HOW) inserting digital technology into learning. The researchers used recording techniques (audio and video) and field notes to complement the observation technique. The observations show that the teacher applies the active student learning method by applying the principle of time distribution for students and teachers. The teacher only uses up to 15% of the available time allocation, and students have more than 85% of the time to do and practice the points on the learning material. Students get extensive opportunities to experience learning with the aim that they will gain and be able to improve 1) their digital skill; 2) the growth and improvement of the students' self-confidence and other soft skills. The students' Youtube content.
Pengaruh Rasio Keuangan Terhadap Kesehatan Koperasi Wanita Di Kecamatan Rejoso Kabupaten Nganjuk
Authors: Noveka Rika Nida 
Published: July 2024

Latar Belakang: Koperasi harus memperhatikan kinerja keuangannya dengan memperhatikan tingkat rasio keuangannya. Dengan tingkat rasio keuangan yang baik, koperasi juga bisa mendapatkan gelar koperasi sehat.
Tujuan: Penelitian yang akan dilakukan bertujuan untuk melihat sejauh mana hubungan antara rasio keuangan (likuiditas, solvabilitas, profitabilitas dan efektivitas) terhadap kesehatan koperasi perempuan di Kecamatan Rejoso, Kabupaten Nganjuk.
Metode Penelitian: Penelitian ini menggunakan jenis penelitian non-eksperimental, yaitu deskriptif dengan pendekatan kuantitatif. Paradigma penelitian ini adalah positivisme yang memandang bahwa fenomena atau gejala dapat diukur. Kesehatan koperasi berdasarkan rasio keuangan akan diukur sesuai dengan Peraturan Menteri Koperasi dan UKM RI Nomor 06.Per/M.KUKM/2006. Untuk mengetahuinya, hubungi variabel peneliti menggunakan pengujian hipotesis dengan bantuan Paket Statistik untuk Ilmu Sosial.
Hasil Penelitian: Penilaian kesehatan koperasi berdasarkan rasio likuiditas, solvabilitas, profitabilitas, dan efektivitas koperasi perempuan di Kabupaten Rejoso, Kabupaten Nganjuk periode 2019-2021 mengalami peningkatan dan penurunan yang signifikan dan dari hasil pengujian hipotesis dapat disimpulkan bahwa sebagian rasio likuiditas, solvabilitas, profitabilitas, dan efektivitas berpengaruh pada Koperasi Wanita di Kabupaten Rejoso periode 2019-2021. Secara simultan, Rasio Likuiditas, Solvabilitas, Profitabilitas dan Aktivitas Mempengaruhi Kesehatan Koperasi Perempuan di Kabupaten Rejoso, Kabupaten Nganjuk periode 2019-2021. Variabel lain menjelaskan rasio keuangan (likuiditas, solvabilitas, profitabilitas dan efektivitas) sebesar 50,8% terhadap kesehatan koperasi perempuan di Kabupaten Rejoso, dan 49,2% sisanya.
Keaslian/Kebaruan Penelitian: Penelitian ini berkontribusi secara teoritis terhadap pengembangan ilmu pengetahuan terkhusus pada pengaruh rasio keuangan terhadap kesehatan koperasi.
THE IMPACT OF THE APPLICATION OF ONLINE LEARNING SYSTEMS DURING THE COVID-19 PANDEMIC ON THE PSYCHOLOGICAL CONDITION AND LEARNING PERFORMANCE OF STUDENTS
Authors: Warsito Hadi , Darminto Eko , Hariastuti Reto Tri , Nuryono Wiryo 
Published: July 2024

The application of online lectures as a lecture system implemented during the Covid-19 Pandemic is currently seen as a solution to comply with the PSBB policy and to maintain lectures that can continue in accordance with the lecture structure as stated in the Semester Learning Plan. It is undeniable, because of its sudden nature (without being preceded by socialization) there are many complaints. The purpose of this study is to describe the psychological condition of students in participating in online system learning in the Covid-19 pandemic situation and its effect on learning performanceThe results of the study prove that there are significant differences in the psychological condition and learning performance of students between before and after the implementation of the online learning system during the Covid-19 pandemic. The measure of student stress after implementing online learning was significantly higher than the measure of stress. Similarly, there are significant differences in the measure of student learning performance between before and after the implementation of online learning during the Covid-19 pandemic.
Formulasi Dan Uji Fisikokimia Gel Sleeping Mask Ekstrak Kulit Buah Naga Merah Dengan Variasi Gelling Agent Hydroxypropyl Methly Cellulose (HPMC)
Authors: Ridha Dwi Aulya  , Nur Ermawati  
Published: July 2024

Gels are semi-solid preparations formed from suspensions made up of large organic molecules and small inorganic particles that permeate the liquid. Sleeping mask It is a skin care product that is used at night (before going to bed). Serious research on natural ingredients is currently being carried out, including research in the field of cosmetics. Among the advantages of natural ingredients is their antioxidant properties, which can disrupt free radicals and cause the use of antioxidants in preventing premature aging. Dragon fruit skin contains compounds polyphenol, anthocyanins and betacyanins which have antioxidant activity. This study aims to determine the effect of the gelling agent Hydroxypropyl Methylcellulose (HPMC) on the physical properties of gel preparations sleeping mask red dragon fruit skin extract. This study uses an experimental method. Red dragon fruit skin is extracted by maceration in 96% ethanol. This study used 3 gel formulations, with various concentrations of HPMC 5%, 7% and 9%. Physicochemical tests carried out included organoleptic tests, homogeneity, pH, spreadability, adhesion, irritation and viscosity. The results of the research show the use of variations gelling agent HPMC meets the criteria for the physicochemical test of gel preparations sleeping mask from dragon fruit skin extract which produces the best formula from gel preparations sleeping mask namely formulation III (9%) has the best evaluation.
Hubungan Jarak Tempuh Dan Efek Samping Terhadap Kepatuhan Kemoterapi Pada Pasien Kanker Serviks
Authors: Elya Rikke Fitriana  , Ns. Anis Ardiyanti  , Nella Vallen Ika Puspita  
Published: July 2024

Cervical cancer is a deadly cancer for women but some medication could be applied, such as chemotherapy. Chemotherapy has some side effects on these patients if they do not obey. This research determined the correlation between the distance coverage and the side effects on the obedience of cervical cancer patients with chemotherapy at DR. Moewardi Surakarta regional hospital. This quantitative research applied a cross-sectional design. The population consisted of 102 cervical cancer patients with chemotherapy. The researchers took the sample with purposive sampling. The samples were 49 patients measured with the questionnaire of chemotherapy obedience and chemotherapy side effect; and the observational guideline of distance coverage. The results showed that most respondents had a far category distance, 45 respondents (91.8%) and maladaptive side effect type, 37 respondents (75.5%). The Spearman rank test showed the correlation between the distance coverage and the obedience with a p-value of 0.004, lower than 0.05. The result also showed the correlation between side effects and obedience with a p-value of 0.044, lower than 0.05. The results found a correlation between the distance coverage and side effects toward the obedience of cervical cancer chemotherapy.
Hubungan Sumber Informasi dengan Kelengkapan Imunisasi Tetanus Toxoid Ibu Primigravida
Authors: Arianggara Andi Wilda , Hafid Rachmi Nurul Hidayat 
Published: July 2024

Tetanus toxoid (TT) immunization is the process of building immunity as an effort to prevent tetanus infection. The coverage of TT immunization at the Kassi-Kassi Health Center is still low. In 2017, out of 1869 pregnant women, the coverage of TT1 immunization was 1516 (81%), and for TT2 coverage was 757 (41%). The achievement of tetanus toxoid immunization coverage can be influenced by several factors, including sources of information and knowledge about TT immunization. The purpose of this study is to determine the relationship between the source and the completeness of Tetanus Toxoid immunization of Mrs. Primigravida at the Kassi-Kassi Health Center in Makassar City. This type of research is an Analytical Survey with a cross-sectional design. The sample in this study is all primigravida mothers with a gestational age of more than 32 weeks and primigravida mothers who have received TT1 and TT2 immunization at the Kassi-Kassi Health Center totaling 35 people. Data analysis uses the Chi-Square test with a confidence level of 95% (?=0.05). The results of the study showed that there was a meaningful relationship between information sources and the Immunization Completeness of Ibu Pimigavida (p=0.020) at the Kassi-Kassi Health Center in Makassar City. Puskesmas is expected to improve promotive and preventive functions to be able to increase public knowledge about TT immunization so that it can increase the coverage of TT immunization.
Kebijakan Pemerintah Terhadap Pendidikan Inklusif
Authors: Erva Karimatunisa  , Taufik Muhtarom  
Published: July 2024

Inclusive education is the education given to students who have the disorder, has the potential intelligence and special talents. Also children are not able to learn for one thing: disability, autism, mental retardation, homeless children, the other had the talent and potential. Inclusive education is a system of educational services for children with special needs in the regular school education and this should be done as early as possible. This is in accordance with the policy internationally and nationally as stipulated in Law No. 20 of 2003 on article 32 and Permendiknas number 70 of 2009, by providing opportunities and opportunities for children with special needs to acquire education in schools regular ranging from elementary school, School junior Highand High School / Vocational. The success of inclusiveeducation will depend on the cooperation of the government, teachers and parents together.
ปัจจัยบุคคลของผู้ใช้น้ำประปาที่ส่งผลต่อการให้บริการของการประปาส่วนภูมิภาคสาขาพยัคฆภูมิพิสัย จังหวัดมหาสารคาม
Authors: บัวทอง อิทธิกร , สุนทร สิทธิพรร์ , เกียรติเจริญ สมเกียรติ 
Published: July 2024

ภูมิหลังและวัตถุประสงค์: การประปาส่วนภูมิภาคเป็นหน่วยงานที่ให้บริการน้ำประปาตาม พ.ร.บ. กปภ. พ.ศ. 2522 โดยคำนึงถึงประโยชน์ของรัฐและสุขอนามัยของประชาชนเป็นสำคัญ ทำให้ผู้วิจัยมีความสนใจที่จะศึกษาเกี่ยวกับปัจจัยบุคคลของผู้ใช้น้ำประปาที่ส่งผลต่อการให้บริการของการประปาส่วนภูมิภาค สาขาพยัคฆภูมิพิสัย จังหวัดมหาสารคามเพื่อนำมาพัฒนาการให้บริการที่ดีต่อไป การวิจัยครั้งนี้ มีวัตถุประสงค์เพื่อศึกษา (1) ระดับปัจจัยบุคคลของผู้ใช้น้ำประปาในการให้บริการของการประปา (2) ระดับการให้บริการของการประปา (3) ปัจจัยบุคคลของผู้ใช้น้ำประปาที่ส่งผลต่อการให้บริการ (4) ข้อเสนอแนะเพื่อนำไปปรับปรุงพัฒนาการให้บริการของการประปาส่วนภูมิภาคสาขาพยัคฆภูมิพิสัย จังหวัดมหาสารคาม
ระเบียบวิธีการวิจัย: กลุ่มตัวอย่างจำนวน 381 คน สถิติที่ใช้ในการวิเคราะห์ข้อมูล ได้แก่ การแจกแจงความถี่ ร้อยละ ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน การทดสอบสมมติฐานด้วยสถิติสัมประสิทธิ์เพียร์สัน และการวิเคราะห์ถดถอยเชิงพหุคูณ (Multiple Regression) โดยวิธี Enter อย่างมีนัยสำคัญทางสถิติที่ระดับ.05 และข้อเสนอแนะผู้วิจัยใช้วิธีการแจกแจงความถี่ และพรรณนาความ
ผลการวิจัย: (1) ระดับปัจจัยบุคคลของผู้ใช้น้ำประปาในการให้บริการของการประปา อยู่ในระดับน้อย (2) ระดับการให้บริการของการประปา อยู่ในระดับมาก (3) ปัจจัยบุคคลของผู้ใช้น้ำประปาที่ส่งผลต่อการให้บริการ อยู่ในระดับน้อย อย่างมีนัยสำคัญทางสถิติที่ .05 มี ตัวแปรที่เข้าสู่สมการที่ดีที่สุดของการวิเคราะห์พหุถดถอย ได้แก่ สถานภาพ สามารถพยากรณ์โดยรวม .420 (R =.420) ตัวแปรอิสระสามารถอธิบายการแปรผันของตัวตามได้เท่ากับร่อยละ 17.6 มีค่า R2 = .176 และมีค่า F = 8.815 ซึ่งแสดงว่าตัวแปรอิสระไม่ส่งผลการให้บริการของการประปาส่วนภูมิภาคสาขาพยัคฆภูมิพิสัย จังหวัดมหาสารคาม (4) ข้อเสนอแนะเพื่อนำไปปรับปรุงพัฒนาการให้บริการของการประปาส่วนภูมิภาคสาขาพยัคฆภูมิพิสัย จังหวัดมหาสารคาม คือ ปรับปรุงการทำงานด้านงานบริการให้สะดวกรวดเร็วเพื่อให้ผู้ใช้น้ำได้รับประโยชน์สูงสุด
สรุปผล: การศึกษาพบว่าแม้การประปานครหลวงจะทำงานได้ดีเป็นพิเศษ แต่ปัจจัยส่วนบุคคลของผู้ใช้น้ำประปาก็มีผลกระทบต่อการให้บริการอย่างมีนัยสำคัญ แม้ว่าจะเล็กน้อยก็ตาม อย่างไรก็ตาม ตัวแปรอิสระดูเหมือนจะไม่ส่งผลกระทบต่อการบริการโดยรวมของการประปาส่วนภูมิภาค บ่งชี้ว่าการปรับปรุงประสิทธิภาพและความสะดวกในการให้บริการมีความจำเป็นต่อความพึงพอใจสูงสุดของลูกค้า