bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Functionalized Chromones Through Sequential Reactions in Aqueous Media.
Authors: Mehrparvar Saber , Balalaie Saeed , Rabbanizadeh Mahnaz , Rominger Frank , Ghabraie Elmira 
Published: December 2014

AbstractThe sequential four‐component reaction of chromone aldehydes (I), meldrum′s acid (II), coumarin (IV) or pyrone (VI) in the presence of primary alcohols (III) leads to coupled products (V) and (VII), respectively.
ChemInform Abstract: Highly Regioselective Lithiation of Pyridines Bearing an Oxetane Unit by N‐Butyllithium.
Authors: Rouquet Guy , Blakemore David C. , Ley Steven V. 
Published: December 2014

AbstractThe regioselective ortho‐lithiation of pyridine derivatives containing a 3‐oxetane substituent is achieved for the first time.
ChemInform Abstract: Ligand‐Enabled Triple C—H Activation Reactions: One‐Pot Synthesis of Diverse 4‐Aryl‐2‐quinolinones from Propionamides.
Authors: Deng Youqian , Gong Wei , He Jian , Yu Jin‐Quan 
Published: December 2014

Abstract4‐Aryl‐2‐quinolinones are prepared from propionamides in one pot by pyridine ligand‐promoted triple sequential C—H activation reactions and a stereospecific Heck reaction.
ChemInform Abstract: Direct Asymmetric Dearomatization of Pyridines and Pyrazines by Iridium‐Catalyzed Allylic Amination Reactions.
Authors: Yang Ze‐Peng , Wu Qing‐Feng , You Shu‐Li 
Published: December 2014

AbstractThe first iridium‐catalyzed intramolecular asymmetric allylic dearomatization reaction of pyridines and pyrazines is developed.
ChemInform Abstract: Copper‐Based Metal—Organic Frameworks as Reusable Heterogeneous Catalysts for the One‐Pot Syntheses of Imidazo[1,2‐a]pyridines.
Authors: Puthiaraj Pillaiyar , Ramu Andy , Pitchumani Kasi 
Published: December 2014

AbstractThe catalyst can be reused at least 5 times with only a slight decrease in yield.
ChemInform Abstract: Titanium Dioxide Supported on MWCNTs as an Eco‐Friendly Catalyst in the Synthesis of 3,4‐Dihydropyrimidin‐2‐(1H)‐ones Accelerated under Microwave Irradiation.
Authors: Safari Javad , Gandomi‐Ravandi Soheila 
Published: December 2014

AbstractSome transition metal oxides supported on multi‐walled carbon nanotubes are prepared and applied as heterogenous catalysts in the Biginelli condensation of aldehydes, β‐dicarbonyl compounds, and (thio)urea.
ChemInform Abstract: Indium(III) Trifluoromethanesulfonate: A Reusable Catalyst for the Solvent‐Free Synthesis of Some Quinazolinones/Thiones.
Authors: Karami Bahador , Khodabakhshi Saeed , Karami Sajad 
Published: December 2014

AbstractThe introduced method leading to quinazolinones (IV) and (VI) and thiones (VIII) has advantages such as avoidance of organic solvents, high yields of pure products, short reaction times, and operational simplicity.
ChemInform Abstract: Synthesis of Quinazolines via CuO Nanoparticles Catalyzed Aerobic Oxidative Coupling of Aromatic Alcohols and Amidines.
Authors: Zhang Wu , Guo Fei , Wang Fei , Zhao Na , Liu Liang , Li Jia , Wang Zhenghua 
Published: December 2014

AbstractCuO nanoparticles are found to be efficient catalysts for the reaction of N‐arylamidines (I) and (IV) and aromatic aldehydes (II) or benzyl alcohols (VI) to afford quinazolines (III) and (V), resp., in good to high yields.
ChemInform Abstract: One‐Pot Synthesis of 2‐Amino‐4(3H)‐quinazolinones via Ring‐Opening of Isatoic Anhydride and Palladium‐Catalyzed Oxidative Isocyanide‐Insertion.
Authors: Ji Fei , Lv Mei‐Fang , Yi Wen‐Bin , Cai Chun 
Published: December 2014

AbstractThe title reaction is applicable to a range of amines (II), isatoic anhydrides (I), and isocyanides (III) and affords the target heterocycles (IV) in moderate to high yields.
ChemInform Abstract: Synthesis of Antiprotozoal Diamines by Regioselective Insertion of Nitrogen into a Bicyclic Ring System.
Authors: Mohsin Noor‐ul‐Amin , Seebacher Werner , Faist Johanna , Belaj Ferdinand , Saf Robert , Kaiser Marcel , Brun Reto , Weis Robert 
Published: December 2014

AbstractThe new compounds (II) and (IV) show only weak antiprotozoal activity, whereas reduction products (III) and (V) exhibit distinct antiplasmodial and antitrypanosomal activities.
ChemInform Abstract: Copper‐Catalyzed Reductive Coupling of Aryl Sulfonyl Chlorides with H‐Phosphonates Leading to S‐Aryl Phosphorothioates.
Authors: Bai Jie , Cui Xiuling , Wang Hui , Wu Yangjie 
Published: December 2014

AbstractA novel, simple, and efficient protocol for the synthesis of S‐aryl phosphorothioates (III) (20 examples) under base‐free conditions is developed.
ChemInform Abstract: An Efficient Synthesis of 1,3‐Dialkylimidazole‐2‐selenones.
Authors: Tian Fengshou , Chen Yahong , Wu Lan , Li Peng , Lu Shiwei 
Published: December 2014

AbstractOptimum reaction conditions are studied for the synthesis of title compounds (II) from 1,3‐dialkylimidazole salts (I) and selenium.
ChemInform Abstract: Perfluoroalkylsulfonyl Fluoride‐Mediated Abnormal Beckmann Rearrangement of Steroid 17‐Oximes with Acid‐Labile Groups.
Authors: Gui Jinghan , Wang Yun , Tian Hailong , Gao Yuqi , Tian Weisheng 
Published: December 2014

Abstract8 examples
ChemInform Abstract: ZnBr2‐Catalyzed and Microwave‐Assisted Synthesis of 2,3‐Unsaturated Glucosides of Hindered Phenols and Alcohols.
Authors: Bound D. James , Bettadaiah B. K. , Srinivas P. 
Published: December 2014

AbstractZnBr2 is shown to be an efficient catalyst for the Ferrier reaction under microwave irradiation.
ChemInform Abstract: A Convenient Strategy for Synthesizing the Agelas Alkaloids Clathrodin, Oroidin, and Hymenidin and Their (Un)saturated Linker Analogues.
Authors: Zula Ales , Kikelj Danijel , Ilas Janez 
Published: December 2014

AbstractLinker amines (I) are prepared as key intermediates for the synthesis of title alkaloids (II).
ChemInform Abstract: A New Enantioselective Synthesis of the anti‐Parkinson Agent Safinamide.
Authors: Reddi Anjaneyulu , Mujahid Mohammad , Sasikumar Murugesan , Muthukrishnan Murugan 
Published: December 2014

AbstractThe presented approach allows a convenient generation of a diverse range of analogues of safinamide.
ChemInform Abstract: Asymmetric 1,3‐Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes
Authors: Nejera Carmen , Sansano Jose M. 
Published: December 2014

AbstractReview: as a route for the synthesis of polysubstituted nitro‐prolines and ‐pyrrolidins; 88 refs.
A Minkowski Inequality for Hypersurfaces in the Anti‐de Sitter‐Schwarzschild Manifold
Authors: Brendle Simon , Hung Pei‐Ken , Wang Mu‐Tao 
Published: December 2014

AbstractWe prove a sharp inequality for hypersurfaces in the n‐dimensional anti‐de Sitter‐Schwarzschild manifold for general n ≥ 3. This inequality generalizes the classical Minkowski inequality for surfaces in the three‐dimensional euclidean space and has a natural interpretation in terms of the Penrose inequality for collapsing null shells of dust. The proof relies on a new monotonicity formula for inverse mean curvature flow and uses a geometric inequality established by the first author in [3].© 2015 Wiley Periodicals, Inc.
Gene flow and population structure of a solitary top carnivore in a human‐dominated landscape
Authors: McManus Jeannine S. , Dalton Desiré L. , Kotzé Antoinette , Smuts Bool , Dickman Amy , Marshal Jason P. , Keith Mark 
Published: December 2014

AbstractWhile African leopard populations are considered to be continuous as demonstrated by their high genetic variation, the southernmost leopard population exists in the Eastern and Western Cape, South Africa, where anthropogenic activities may be affecting this population's structure. Little is known about the elusive, last free‐roaming top predator in the region and this study is the first to report on leopard population structuring using nuclear DNA. By analyzing 14 microsatellite markers from 40 leopard tissue samples, we aimed to understand the populations' structure, genetic distance, and gene flow (Nm). Our results, based on spatially explicit analysis with Bayesian methods, indicate that leopards in the region exist in a fragmented population structure with lower than expected genetic diversity. Three population groups were identified, between which low to moderate levels of gene flow were observed (Nm 0.5 to 3.6). One subpopulation exhibited low genetic differentiation, suggesting a continuous population structure, while the remaining two appear to be less connected, with low emigration and immigration between these populations. Therefore, genetic barriers are present between the subpopulations, and while leopards in the study region may function as a metapopulation, anthropogenic activities threaten to decrease habitat and movement further. Our results indicate that the leopard population may become isolated within a few generations and suggest that management actions should aim to increase habitat connectivity and reduce human–carnivore conflict. Understanding genetic diversity and connectivity of populations has important conservation implications that can highlight management of priority populations to reverse the effects of human‐caused extinctions.
S = 2 Spin Ladders in the Sulfide Oxide BaFe2S2O
Authors: Valldor Martin , Adler Peter , Prots Yurii , Burkhardt Ulrich , Tjeng Liu Hao 
Published: December 2014

AbstractInvited for the cover of this issue is the group of Martin Valldor at MPI CPfS, Dresden, Germany. The cover image shows globular grains within the particles of BaFe2S2O and their pleochroitic behavior, as seen with polarized light. Superimposed on this background is a part of the crystal structure of the title compound.
Values and behavior: Validating the refined value theory in Russia
Authors: Schwartz Shalom H. , Butenko Tania 
Published: December 2014

AbstractResearchers recently introduced a refined theory of 19 basic human values. They demonstrated its utility and discriminant validity through associations with attitudes and beliefs, but not with behaviors. We assess the discriminant and predictive validity of the theory by examining associations of each value with everyday behaviors in a Russian sample. Two hundred sixty‐six respondents reported their values and the frequency with which they performed each of the 85 everyday behaviors during the past year. We derived indexes of 19 latent value factors and of 19 latent behavior factors using confirmatory factor analysis. A confirmatory multidimensional scaling analysis arrayed the values, excepting benevolence, on the circular motivational continuum of the theory. Structural equation modeling analyses supported the discriminant and predictive validity of the theory. Of the 19 values, 18 correlated more positively with the behavior chosen a priori as likely to express it than with any other behavior, and all values correlated negatively with behaviors chosen to express motivationally opposed values. The patterns of correlation between the values and behaviors approximated the sinusoid curve implied by the motivational continuum of values in almost all cases. The study suggests that the same motivational compatibilities and conflicts that structure value relations largely organize relations among value‐expressive behaviors. The study examines moderation of value–behavior relations by gender and tests the normative pressure explanation of variation in the strength of value–behavior relations across value domains. Copyright © 2014 John Wiley & Sons, Ltd.
Effects of fibroblasts on the function of acinar cells from the same human parotid gland
Authors: Chou Ya‐Shuan , Lin Yong‐Chong , Young Tai‐Horng , Lou Pei‐Jen 
Published: December 2014

AbstractBackgroundArtificial salivary gland replacement would be an ideal treatment for xerostomia. In vivo, salivary gland cells are surrounded by a complex stromal environment in which fibroblasts are the main cell type in proximity to the gland cells. However, very little is known about the relationship between these fibroblasts and the gland cells.MethodsParotid gland acinar cells (PGACs) and fibroblasts from the same human gland were cocultured. PGAC function‐related protein expression was investigated.ResultsThe expression of α‐amylase in PGACs was increased in a fibroblast ratio‐dependent manner. Both fibroblast‐conditioned medium and direct coculture also significantly enhanced the PGAC expression of α‐amylase. Basic fibroblast growth factor (bFGF) seems to be a regulator of α‐amylase expression in PGACs.ConclusionAn appropriate number of fibroblasts in contact with the PGACs is necessary to promote PGAC function. Fibroblast‐secreted bFGF may play a paracrine signaling role in the regulation of α‐amylase expression in PGACs. © 2015 Wiley Periodicals, Inc.Head Neck38: E279–E286, 2016
Fate of patients with nasopharyngeal cancer who developed distant metastasis as first failure after definitive radiation therapy
Authors: Chang Ji Hyun , Ahn Yong Chan , Park Hyojung , Oh Dongryul , Noh Jae Myoung , Sun Jong‐Mu , Ahn Myung‐Ju , Park Keunchil 
Published: December 2014

AbstractBackgroundNo consensus has been reached on the optimal treatment for patients with nasopharyngeal cancer (NPC) who develop distant metastasis after initial radiation therapy (RT).MethodsTwo hundred eighty‐two patients with NPC received curative RT (+/‐ chemotherapy). Forty‐six patients (16.3%) who developed distant metastasis as first failure formed the study group for the current analysis.ResultsThe median interval from initial RT until distant metastasis was 11.6 months. With a median follow‐up of 30 months among survivors, overall survival (OS) rates at 2 and 5 years were 53.7% and 30.5%, respectively. On multivariate analyses, 18F‐fluorodeoxyglucose (FDG)‐positron emission tomography (PET)/CT for initial staging, RT plus chemotherapy as initial treatment, metastatic lesion number <6, disease‐free interval >9 months, distant metastasis only to lungs, and treatment with curative intent after distant metastasis were predictive of significantly better OS.ConclusionCombined with FDG‐PET/CT, an aggressive treatment approach using locoregional modalities might be beneficial to patients with NPC with favorable prognostic factors, even after distant metastasis. © 2015 Wiley Periodicals, Inc. Head Neck 38: E293–E299, 2016
Electrodeposited silk coatings for bone implants
Authors: Elia Roberto , Michelson Courtney D. , Perera Austin L. , Brunner Teresa F. , Harsono Masly , Leisk Gray G. , Kugel Gerard , Kaplan David L. 
Published: December 2014

AbstractThe aim of this study was to characterize the mechanical properties and drug elution features of silk protein‐based electrodeposited dental implant coatings. Silk processing conditions were modified to obtain coatings with a range of mechanical properties on titanium studs. These coatings were assessed for adhesive strength and dissolution, with properties tuned using water vapor annealing or glycerol incorporation to modulate crystalline content. Coating reproducibility was demonstrated over a range of silk concentrations from 1% to 10%. Surface roughness of titanium substrates was altered using industry relevant acid etching and grit blasting, and the effect of surface topography on silk coating adhesion was assessed. Florescent compounds were incorporated into the silk coatings, which were modulated for crystalline content, to achieve four days of sustained release of the compounds. This silk electrogelation technique offers a safe and relatively simple approach to generate mechanically robust, biocompatible, and degradable implant coatings that can also be functionalized with bioactive compounds to modulate the local regenerative tissue environment. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1602–1609, 2015.
The power of disruptive technological innovation: Transcatheter aortic valve implantation
Authors: Berlin David B. , Davidson Michael J. , Schoen Frederick J. 
Published: December 2014

AbstractWe sought to evaluate the principles of disruptive innovation, defined as technology innovation that fundamentally shifts performance and utility metrics, as applied to transcatheter aortic valve implantation (TAVI). In particular, we considered implantation procedure, device design, cost, and patient population. Generally cheaper and lower performing, classical disruptive innovations are first commercialized in insignificant markets, promise lower margins, and often parasitize existing usage, representing unattractive investments for established market participants. However, despite presently high unit cost, TAVI is less invasive, treats a “new,” generally high risk, patient population, and is generally done by a multidisciplinary integrated heart team. Moreover, at least in the short‐term TAVI has not been lower‐performing than open surgical aortic valve replacement in high‐risk patients. We conclude that TAVI extends the paradigm of disruptive innovation and represents an attractive commercial opportunity space. Moreover, should the long‐term performance and durability of TAVI approach that of conventional prostheses, TAVI will be an increasingly attractive commercial opportunity. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1709–1715, 2015.
A Systematic Review of Mindfulness and Acceptance‐Based Treatments for Social Anxiety Disorder
Authors: Norton Alice R. , Abbott Maree J. , Norberg Melissa M. , Hunt Caroline 
Published: December 2014

ContextThe cultivation of mindfulness and acceptance has been theoretically and empirically associated with psychological ancillary well‐being and has demonstrated efficacy in the treatment of various disorders. Hence, mindfulness and acceptance‐based treatments (MABTs) have recently been explored for the treatment of social anxiety disorder (SAD). This review aims to evaluate the benefits of MABTs for SAD.MethodsSystematic review of studies investigating an MABT for individuals with SAD, using PsycInfo, Medline, PubMed, and Cochrane Central Register of Controlled Trials.ResultsNine studies were identified. Significant improvements in symptomatology were demonstrated following the MABT, but benefits were equivalent or less than yielded by cognitive‐behavioral therapy (CBT).LimitationsThe few treatment studies available were compromised by significant methodological weaknesses and high risk of bias across domains. Studies were largely uncontrolled with small sample sizes. The hybrid nature of these interventions creates ambiguity regarding the specific utility of treatment components or combinations.ConclusionsMABTs demonstrate significant benefits for reducing SAD symptomatology; however, outcomes should be interpreted with caution until appropriate further research is conducted. Furthermore, the benefit of MABTs above and beyond CBT must be considered tentative at best; thus, CBT remains best practice for first‐line treatment of SAD.
Comparison of treatment outcomes of transnasal vocal fold polypectomy versus microlaryngoscopic surgery
Authors: Wang Chi‐Te , Liao Li‐Jen , Huang Tsung‐Wei , Lo Wu‐Chia , Cheng Po‐Wen 
Published: December 2014

Objectives/HypothesisOffice‐based procedures have been proposed for the treatment of vocal polyps, including indirect laryngoscopic surgery and angiolytic laser photocoagulation. Our previous report documented good treatment outcomes by combining the two aforementioned procedures. This study was intended to further compare the treatment outcomes of office transnasal vocal fold polypectomy (VFP) with those of microlaryngoscopic surgery (MLS).Study DesignA matched cohort study.MethodsThis study retrospectively enrolled 50 age‐, gender‐, and size‐matched patients with vocal polyps treated by VFP or MLS at a tertiary teaching hospital from January 2012 to October 2013. Treatment outcomes were evaluated before, 2 weeks, and 6 weeks after the procedures via perceptual rating of voice quality, acoustic measurement of the speech signal, 10‐item voice‐handicap index, maximal phonation time, subjective rating of voice quality, and videolaryngostroboscopic evaluation.ResultsBoth VFP and MLS resulted in significant clinical improvements 2 and 6 weeks postoperatively. Study results exhibited similar objective outcomes between VFP and MLS, whereas patients who received VFP reported higher subjective voice quality than those receiving MLS 2 weeks postoperatively. Six weeks after the procedures, the objective and subjective treatment outcomes were not significantly different between the two treatment groups.ConclusionThis study shows that transnasal VFP may be used as an effective alternative treatment for small vocal polyps. Patients who received office VFP experienced rapid symptomatic relief with a higher degree of subjective effectiveness than MLS 2 weeks postoperatively, whereas the overall treatment outcomes showed a comparable level of effectiveness for both modalities.Level of Evidence3B. Laryngoscope, 125:1155–1160, 2015
Theoretical Description of an Anomalous Elongation During Two‐Way Shape‐Memory Effect in Crosslinked Semicrystalline Polymers
Authors: Dolynchuk Oleksandr , Kolesov Igor , Radusch Hans‐Joachim 
Published: December 2014

SummaryThe present study is focused on theoretical explanation of an anomalous elongation arising during non‐isothermal crystallization of crosslinked semicrystalline polymers under constant load that represents the first stage of two‐way shape‐memory effect (SME) in these materials. The proposed theoretical approach allows calculating the free energy change of a specimen deformed under constant load and cooled down below crystallization temperature at constant cooling rate, i.e. in non‐isometric and non‐isothermal conditions, respectively. The theory was confirmed for a crosslinked high‐density polyethylene chosen as a model object. It was shown that aforementioned anomalous elongation may be observed when the orientation of chain folds in crystals generating at cooling under load is parallel to or makes a sharp angle with the stretch direction. The stress‐strain‐temperature relationship derived from the free energy change was used to fit the experimental findings of the two‐way SME in crosslinked high‐density polyethylene. The fitting curves have shown well agreement with the experimental values.
Heterogeneous Cross‐Linking and Sulphation of Chitosan
Authors: Höhne Susanne , Breier Annette , Jäger Maria , Hanke Thomas , Worch Hartmut , Simon Frank 
Published: December 2014

SummaryChitosan textile scaffolds are novel promising biomaterials for application in tissue engineering. The intro­duction of sulphate groups in the chitosan molecule leads to a biomaterial that combines two important features. At first it's an excellent material in order to build scaffolds for tissue engineering, and at second it is able to mimic the beneficial interaction of natural occurring sulphated polysaccharides with growth factors. Known sul­phating methods, developed for the sulphation of chitosan in solutions (homogeneous phase reactions), were adapted to apply them on solid chitosan surfaces (heterogeneous phase reactions). Surface reactions preventing the chitosan's dissolution were funda­mentally necessary to keep the predetermined geometric structure of the scaffolds during derivatization reactions. Model studies were carried out on chitosan particles as well as chitosan textiles. Points of interests were the control of the regio­selectivity of the sulphation reactions and the adjustment of the degree of sulphation. It was shown that a partial cross‐linking of chitosan is a key tool to keep the geometric structure of the chitosan particles and fibres during the subsequent sulphation reaction. The modified samples were comprehen­sively characterized by means of X‐ray photoelectron spectroscopy and elemental analysis.