bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tensed evidentials: A typological study
Authors: Visser Eline 
Published: October 2015

AbstractTo gain more insight into evidentiality, the grammatical marking of information source, it is worth studying the category in its relation to other grammatical categories. This study explores tensed evidentials, morphemes in which tense and evidentiality are fused, in 36 languages from four macro-areas (North America, South America, Eurasia, and Papunesia). The study reveals several interactions between tense values and evidential values. As opposed to what has been claimed, firsthand future evidentials seem to exist. Visual and non-visual evidentials occur equally with present and past, whereas mental activity evidentials and reportative evidentials are much more limited to the past. These findings conform to the logic of tense: every type of evidentiality can be gathered in the past, whereas some are less suited for present or future. As a result, we find exceptionless implicational hierarchies of the form
Analysis of paraoxonase-1 (PON1) gene polymorphisms in vitiligo / Vitiligo’da paroksinaz-1 (PON1) gen polimorfizminin araştırılması
Authors: Seçkin Havva Yıldız , Kalkan Göknur , Benli İsmail , Bütün İlknur , Baş Yalçın , Takçı Zennure , Karakuş Nevin 
Published: October 2015

Abstract
Objective: Vitiligo is a chronic autoimmune depigmentation disease, which is characterized by loss of function of the melanocytes in epidermis. Recent studies suggest that oxidant/antioxidant status plays important role in the pathogenesis of vitiligo. We aimed to investigate possible associations between vitiligo and PON1 M / L55 and PON Q192R gene polymorphisms in the Turkish community.
Methods: The 57 patients with vitiligo and 69 healthy controls were enrolled into the study. Genotyping was performed to identify PON1 M / L55 and PON Q192R gene polymorphism. Genotype and allele frequencies were compared between patients with vitiligo and healthy control group.
Results: In patients (p=0.0061) and healthy controls (p=0.550), there was no significant statistical difference between L55M and Q192R polymorphisms of the PON1 gene. However, when L55M polymorphism was compared to MM homozygous genotype and LL+LM genotypes, it was notably higher in controls than in patients, which seems to be protective against the disease (p=0.034, OR:0. 3, 95% CU: 0.08-0.93). Although, there was no not a statistical difference in allele frequencies of Q192R polymorphism between patients and controls (p=0.242), the M allele of L55M polymorphism was significantly higher in controls than in patients with vitiligo, which means that it might be protective against vitiligo (p=0.009, OR: 0.48, 95% CI: 0.27-0.84).
Conclusion: Even though there were no differences between patients and controls, this is the first study that investigated the possible associations between the PON1 M/L55 and PON Q192R gene polymorphisms within the Turkish population.
Sub-micrometric and nanometric solid phases obtained through reductive decomposition reaction of β-cyclodextrin / Β-siklodekstrin indirgeyici bozunma reaksiyonu yoluyla elde edilen alt mikrometrik ve nanometrik katı fazlar
Authors: Blanco Kate Cristina , Santos Francisco José dos , Júnior Miguel Jafelicci , Vettori Mary Helen Palmuti Braga , Franchetti Sandra Mara Martins , Contiero Jonas 
Published: October 2015

AbstractObjective: Cyclodextrins have been used to catalyze chemical reactions in the synthesis of different materials. The aim of this study is to produce nanoparticles using cyclodextrin as a nanoreactor.Methods: In this study, nanoparticles from the solid phase of iron oxide (Fe3O4), copper oxide (CuO) and metallic silver (Ago) were obtained through hydrothermal synthesis at 100 and 150°C for six hours. This was produced for cyclodextrin glycosyltransferase from Bacillus lehensis isolated from wastewater of a cassava flourmill. The nanoparticles were characterized through x-ray diffraction Fourier transform infrared spectroscopy and field emission gun scanning electron microscopy.Results: The images demonstrated that the nanoparticles exhibited a polyhedric shape with a diameter of 100 nm for Fe4O3, an irregular oval shape with a diameter of 45 nm for CuO and a platelet shape with a diameter of 138 nm for Ago.Conclusion: Based on this characterization, the proposed technique proved to be an efficient, low-cost, convenient method for the production of sub-micrometric and nanometric solid phases and can likely be scaled up for industrial use. The results demonstrate the possibility of producing nanoparticles using cyclodextrin as a nanoreactor.
Is median value of Double Screening Test regional? / İkili Tarama Testi medyan değerleri bölgesel midir?
Authors: Erdemli Hacı Kemal , Kocabaş Ramazan , Özdemir Tülay , Bedir Abdulkerim 
Published: October 2015

Abstract
Objective: The median values of double test which is commonly used for Down Syndrome screening show diversity between countries. In this study, we aimed to investigate the possible differences in corrected multiplies of median (MoM) values of individiuals between the two cities of the same geographic region.
Methods: Blood samples for double test analysis, sent from Corum and Samsun, were studied in the same laboratory. Results of double test analyses were retrospectively evaluated. Mann-Whitney U test was used for comparison of corrected MoM values of free human chorionic gonadotropin (f-β hCG) and pregnancy-specific plasma protein-A (PAPP-A) according to gestational age. Results were given as median (minimum-maximum) values. The p <0.05 was considered significant.
Results: The corrected f-β hCG values obtained from Corum and Samsun were as follows: 0.75 (0.24-2.11, n=28), 0.85 (0.21-2.95, n=143) (p=0.378) in 10th gestational week; 0.75 (0.17-4.15, n=349), 0.84 (0.14-4.76, n=672) (p=0.005) in 11th gestational week; 0.81 (0.15-5.15, n=542), 0.86(0.19-5.18, n=946) (p=0.014) in 12th gestational week; 0.77 (0.20-6.32, n=365), 0.87 (0.20-5.54, n=327) (p=0.054) in 13th gestational week, respectively. Corrected PAPP-A values from Corum and Samsun were as follows: in 10th gestational week 0.94 (0.41-5.57), 0.87(0.19-3.53) (p=0.425); in 11th gestational week 0.88 (0.21-3.61), 0.89 (0.19-3.70) (p=0.963); in 12th gestational week 0.89 (0.22-4.24), 0.90 (0.15-4.99) (p=0.704); in 13th gestational week 0.93 (0.19-2.70), 0.90 (0.09-2.80) (p=0.952) respectively.
Conclusion: The MoM values of f-β hCG tests, derived from individuals from Corum and Samsun, both located in the Central Black Sea Region, were found to be different. This finding indicates that for double test analysis, different median values may be used for patients from different cities.
Determination of the Temperature-Dependent OH− (H2O) + CH3I Rate Constant by Experiment and Simulation
Authors: Xie Jing , Scott Michael J. , Hase William L. , Hierl Peter M. , Viggiano Albert A. 
Published: October 2015

Abstract
Experimental and simulation studies of the
OH
–
(H2O) + CH3I reaction give temperature
dependent rate constants which are in excellent agreement. Though
there are statistical uncertainties, there is an apparent small
decrease in the rate constant as the temperature is increased from
− 60 to 125 ℃, and for this temperature range the
rate constant is ∼ 1.6 times smaller than that for the
unsolvated reactants OH
–
+ CH3I. Previous work
[J. Phys. Chem. A 117 (2013) 14019] for the unsolvated
reaction found that the S
N
2 and proton transfer pathways,
forming CH3OH + I
–
and
CH2I
–
+ H2O, have nearly equal
probabilities. However, for the microsolvated
OH
–
(H2O) + CH3I reaction the S
N
2
pathways dominate. An important contributor to this effect is the
stronger binding of H2O to the OH
–
reactant than
to the proton transfer product CH2I
–
, increasing the
barrier for the proton transfer pathway. The effect of microsolvation
on the rate constant for the
OH
–
(H2O)0,1 + CH3I reactions agrees with
previous experimental studies for
X
–
(H2O)0,1 + CH3Y reactions. The
simulations show that there are important non-statistical attributes
to the entrance- and exit-channel dynamics for the
OH
–
(H2O) + CH3I reaction.
Long-term effects of pegvisomant on comorbidities in patients with acromegaly: a retrospective single-center study
Authors: Kuhn Emmanuelle , Maione Luigi , Bouchachi Amir , Rozière Myriam , Salenave Sylvie , Brailly-Tabard Sylvie , Young Jacques , Kamenicky Peter , Assayag Patrick , Chanson Philippe 
Published: October 2015

ContextThe effect of pegvisomant on IGF1 levels in patients with acromegaly is well documented, but little is known of its long-term impact on comorbidity.AimThe aim of this retrospective study was to evaluate the effects of long-term pegvisomant therapy on cardiorespiratory and metabolic comorbidity in patients with acromegaly.Patients and methodsWe analyzed the long-term (up to 10 years) effect of pegvisomant therapy given alone (n=19, 45%) or in addition to somatostatin analogues and/or cabergoline (n=23, 55%) on echocardiographic, polysomnographic and metabolic parameters in respectively 42, 12 and 26 patients with acromegaly followed in Bicêtre hospital.ResultsAt the first cardiac evaluation, 20±16 months after pegvisomant introduction, IGF1 levels normalized in 29 (69%) of the 42 patients. The left ventricular ejection fraction (LVEF) improved significantly in patients whose basal LVEF was ≤60% and decreased in those whose LVEF was >70%. The left ventricular mass index (LVMi) decreased from 123±25 to 101±21 g/m2(P<0.05) in the 17 patients with a basal LVMi higher than the median (91 g/m2), while it remained stable in the other patients. Pegvisomant reduced the apnoea–hypopnea index and cured obstructive sleep apnea (OSA) in four of the eight patients concerned. Long-term follow-up of 22 patients showed continuing improvements in cardiac parameters. The BMI and LDL cholesterol level increased minimally during pegvisomant therapy, and other lipid parameters were not modified.ConclusionsLong-term pegvisomant therapy not only normalizes IGF1 in a large proportion of patients but also improves cardiac and respiratory comorbidity.
3D-BIOPRINTING (Application of 3D printer for Organ Fabrication)
Authors: Aishwarya Y. , Gourangi B. , Abhijeet K. 
Published: October 2015

A chronic shortage of human organs for transplantation has become more problematic in spite of major development in transplant technologies. In 2009, only 27,996 (18%) of 154,324 patients received organs and 8,863 (25 per day) died while on the waiting list. As of early 2014, approximately 120,000 people in the U.S. were awaiting an organ transplant.
The solution to this problem is 3D bio-printing. This technology may provide a unique and new opportunity where we can print 3D organs. It incorporates two technologies, tissue engineering, and 3D printing. 3D bioprinting involves dispensing cells onto a biocompatible scaffold using a successive layer-by-layer approach to generate tissue-like three-dimensional structures.
It uses instruction in the CAD file for the formation of the object, high-level computer programming, and the ability to build highly advanced computer systems, it offers hope for bridging the gap between organ shortage and transplantation needs.
Numerical Prediction Of The Effects Of Miniature Channel Shaped Scratches On The Fracture Behaviour Of Wires For Civil Engineering Applications Using Finite Element Analysis
Authors: Adewole K.K. , Bull S.J. 
Published: October 2015

Abstract
The effects of the miniature channel-shaped scratches not detectable by the present inline electromagnetic defect detection system employed for wires’ surface defect detection on the fracture behaviour of the wires for civil engineering applications were investigated numerically. Finite element analysis revealed that both miniature channel-shaped across-the-thickness and across-the-width scratches change the fracture behaviour of the wires in terms of the fracture initiation locations and fracture process sequence. However, miniature across-the-thickness scratches does not affect the fracture shape of the wire while miniature across-the-width scratches changed the wires’ cup and cone fracture to a fracture shape with a predominantly flat fracture. These results provide an understanding of the fracture behaviour of wires with miniature scratches and serve as an alternative or a complimentary tools to experimental or fractographic failure analysis of wires with miniatures scratches which are difficult to carry out in the laboratory due to the sizes of the scratches.
Assessment Of The Casting Position Factor In Reinforced Concrete Elements In View Of Experimental Studies
Authors: Dybeł Piotr , Furtak Kazimierz 
Published: October 2015

Abstract
The paper presents the results of experimental investigations performed by the authors on the casting position factor. It was proved that at the height of reinforced concrete elements there are different bond conditions. Moreover, the bond depends on concrete mechanical properties, element height as well as concrete mix composition and consistency. The experiments also showed the advisability of determining the casting position factor separately for bars from normal concrete and those from high–performance concrete (HPC). The analysis of investigation results has shown that “good” bond conditions are a relative concept and depend on, among other things, element height. The higher the element the better the concrete to lower bars bond. Consequently, elements of considerable height (higher than 600 mm) demonstrate a bigger difference between concrete to upper bars bond and concrete to lower bars bond.
Dome Over The Gdynia Seaport Building
Authors: Godycki-Ćwirko T. , Nagrodzka-Godycka K. , Piotrkowski P. 
Published: October 2015

Abstract
The paper presents the description of structure and the selected problems of the technical condition, as well as the strength analysis of the thin-walled reinforced concrete shell which has been making a covering of the main hall of the Gdynia Seaport Building through the last 80 years. The rectangle projection of four single curvature shells of the dome was shaped out of mutual perpendicular intersection of two cylindrical shells.
The analysis of the state of stress and deformations was carried out using the special model worked out in MES considering the combination of loads, the thermal ones included. For the long lasting loads (the deadweight of the dome), the computed results of static quantities were confronted with analytical results obtained according to F. Dischinger’s method. This method had been applied by the DYWIDAG Company in Berlin and its branch in Katowice (Poland) who designed the Gdynia Dome.
The computational analysis and the assessment of the technical state, along with laboratory pH tests of concrete, made it possible to carry out the overall evaluation of durability and safety of operation of the Gdynia Seaport Dome through the next decades.
Multipoint Ultrasonic Diagnostics System Of Prestressed T-Beams
Authors: Mariak A. , Wilde K. 
Published: October 2015

AbstractThis paper is devoted to the application of ultrasonic wave propagation phenomena for the diagnostics of prestressed, concrete, bridge T-beams. A multi-point damage detection system is studied with use of numerically obtained data. The system is designed to detect the presence of the material discontinuities as well as their location.
Results of wrist extension reconstruction in C5–8 brachial plexus palsy by transferring the pronator quadratus motor branch to the extensor carpi radialis brevis muscle
Authors: Bertelli Jayme Augusto , Ghizoni Marcos Flávio , Tacca Cristiano Paulo 
Published: October 2015

OBJECT
The objective of this study was to report the results of pronator quadratus (PQ) motor branch transfers to the extensor carpi radialis brevis (ECRB) motor branch to reconstruct wrist extension in C5–8 root lesions of the brachial plexus.

METHODS
Twenty-eight patients, averaging 24 years of age, with C5–8 root injuries underwent operations an average of 7 months after their accident. In 19 patients, wrist extension was impossible at baseline, whereas in 9 patients wrist extension was managed by activating thumb and wrist extensors. When these 9 patients grasped an object, their wrist dropped and grasp strength was lost. Wrist extension was reconstructed by transferring the PQ motor to the ECRB motor branch. After surgery, patients were followed for at least 12 months, with final follow-up an average of 22 months after surgery.

RESULTS
Successful reinnervation of the ECRB was demonstrated in 27 of the 28 patients. In 25 of the patients, wrist extension scored M4, and in 2 it scored M3.

CONCLUSIONS
In C5–8 root injuries, wrist extension can be predictably reconstructed by transferring the PQ motor branch to reinnervate the ECRB.
Building an electronic health record integrated quality of life outcomes registry for spine surgery
Authors: Azad Tej D. , Kalani Maziyar , Wolf Terrill , Kearney Alisa , Lee Yohan , Flannery Lisa , Chen David , Berroya Ryan , Eisenberg Matthew , Park Jon , Shuer Lawrence , Kerr Alison , Ratliff John K. 
Published: October 2015

OBJECT
Demonstrating the value of spine care requires adequate outcomes assessment. Long-term outcomes are best measured as overall improvement in quality of life (QOL) after surgical intervention. Present registries often require parallel data entry, introducing inefficiencies and limiting compliance. The authors detail the methodology of constructing an integrated electronic health record (EHR) system to collect QOL metrics and demonstrate the effect of data collection on routine clinical workflow. A streamlined approach to collecting QOL data can capture patient data without requiring dual data entry and without increasing clinic visit times.

METHODS
Through extensive literature review, a combination of QOL assessments was selected, consisting of the Patient Health Questionnaire-2 and -9, Oswestry Disability Index, Neck Disability Index, and visual analog scale for pain. These metrics were used to provide assessment of QOL following spine surgery and were incorporated into standard clinic workflow by a multidisciplinary team of surgeons, advanced practice providers, and health care information technology specialists. A clinical dashboard tracking more than 25 patient variables was developed. Clinic flow was assessed and opportunities for improvement reviewed. Duration of clinic visits before and after initiation of QOL measure capture was recorded, with assessment of mean clinic visit times for the 12 months before and the 12 months after implementation.

RESULTS
The integrated QOL capture was instituted for 3 spine surgeons in a tertiary care academic center. In the 12-month period prior to initiating collection of QOL data, 806 new patient visits were completed with an average visit time of 127.9 ± 51.5 minutes. In the 12 months after implementation, 1013 new patient visits were recorded, with 791 providing QOL measures with an average visit time of 117.0 ± 45.7 minutes. Initially the primary means of collecting patient outcome data was via paper form, with gradual transition to collection via entry into the electronic medical records system. To improve electronic data capture, paper forms were eliminated and an online portal used as part of the patient rooming process. This improved electronic capture to nearly 98% without decreasing the number of patients enrolled in the process.

CONCLUSIONS
A systematic approach to collecting spine-related QOL data within an EHR system is feasible and offers distinct advantages over registries that require dual data entry. The process of data collection does not impact patients’ clinical visit or providers’ clinical workflow. This approach is scalable, and may form the foundation for a decentralized outcomes registry network.
Endoscopic fenestration of intraventricular cerebrospinal fluid cysts: the contralateral approach
Authors: Hugelshofer Michael , Koechlin Nicolas Olmo , Marcus Hani J. , Kockro Ralf A. , Reisch Robert 
Published: October 2015

OBJECT
The endoscopic fenestration of intraventricular CSF cysts has evolved into a well-accepted treatment modality. However, definition of the optimal trajectory for endoscopic fenestration may be difficult. Distorted ventricular anatomy and poor visibility within the cyst due to its contents can make endoscopic fenestration challenging if approached from the ipsilateral side. In addition, transcortical approaches can theoretically cause injury to eloquent cortex, particularly in patients with dominant-sided lesions. The aim of this study was to examine the value of the contralateral transcortical transventricular approach in patients with dominant-sided ventricular cysts.

METHODS
During a 5-year period between 2007 and 2011, 31 patients with intraventricular CSF cysts underwent surgery by the senior author (R.R.). Fourteen of these patients had cysts located on the dominant side. An image-guided endoscopic cyst fenestration via the contralateral transcortical transventricular approach was performed in 11 patients. A retrospective chart review was performed in all these patients to extract data on clinical presentation, operative technique, and surgical outcome.

RESULTS
The most common presenting symptom was headache, followed by memory deficits and cognitive deterioration. In all cases CSF cysts were space occupying, with associated obstructive hydrocephalus in 8 patients. Image-guided endoscopic fenestration was successfully performed in all cases, with septum pellucidotomy necessary in 6 cases, and endoscopic third ventriculostomy in 1 case for additional aqueductal occlusion. Postoperative clinical outcome was excellent, with no associated permanent neurological or neuropsychological morbidity. No recurrent cysts were observed over a mean follow-up period of 2 years and 3 months.

CONCLUSIONS
The contralateral approach to ventricular cysts can achieve excellent surgical outcomes while minimizing approach-related trauma to the dominant hemisphere. Careful case selection is essential to ensure that the contralateral endoscopic trajectory is the best possible exposure for sufficient cyst fenestration and restoration of CSF circulation.