bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Bismuth on Physical and Spectroscopic Properties of ZnO-Li2B4O7-TbF3 Glasses
Authors: Talari Kurumurthy , K. Chandra Sekar  , Boora Srinivas  , D. Sreenivasu  , Md. Shareefuddin  
Published: July 2024

The effect of Bismuth on zinc-lithium tetra borate glasses were discussed based on structural, physical, and spectroscopic properties. Glass systems of Bi2O3-ZnO-Li2B4O7-TbF3 [BZLT] were cast by melt-quench process. Transparent glasses were analysed by diffracted Roentgen X-rays. Peak free and broad nature X-ray diffraction revealed the amorphous arrangement prevailing in these glasses. Density was estimated using the Archimedes principle. Bismuth grossly affected the density of BZLT glasses by increasing its value 2.722 gm/cc [BZLT-0] to 4.6739 gm/cc [BZLT-40]. Optical absorption provides valuable information about optical band gap energy and Urbach energy and some of its derived physical quantities. The effect of bismuth is felt in decreased Eopt values [3.312 eV in BZLT-0] [2.619 eV in BZLT-40] in BZLT glasses. Bismuth altered the structure of the borate network by forming non-bridging oxygens which in turn reduced the band gap energy by large margin (ΔEopt = 0.693 eV). Fourier transform infrared spectroscpy and Raman studies revealed the presence of several triangular BO3 and tetrahedral BO4 and BiO3 units and also the existence of metal cation vibrations and supported the large deviations in the optical bandgap energies. Election paramagnetic resonance studies support the presence of Tb3+ ions and absence of Tb4+ions in BZLT glasses.
A DXd/TLR7-Agonist Dual-Conjugate Anti-HER2 ADC Exerts Robust Antitumor Activity Through Tumor Cell Killing and Immune Activation
Authors: Yue Hangtian , Xu Hui , Ma Lanping , Li Xiyuan , Yang Biyu , Wang Xiyuan , Zeng Qingzhong , Li Han , Zhang Deqiang , Geng Meiyu , Meng Tao , Xie Zuoquan 
Published: July 2024

Abstract
The emergence of trastuzumab deruxtecan (T-DXd), a new-generation antibody–drug conjugate (ADC), has profoundly altered the therapeutic paradigm for HER2-positive solid tumors, demonstrating remarkable clinical benefits. However, the combined outcomes of T-DXd with immunotherapy agents remain ambiguous. In this study, we introduce Tras-DXd-MTL1, an innovative HER2 targeting ADC that integrates the topoisomerase inhibitor DXd and a toll like receptor 7 (TLR7) agonist MTT5, linked to trastuzumab via a GGFG tetrapeptide linker. Mechanistically, Tras-DXd-MTL1 retains the DNA-damaging and cell-killing properties of topoisomerase inhibitors while simultaneously enhancing the immune response within the tumor microenvironment. This is achieved by promoting immune cell infiltration and activating dendritic cells and CD8+T cells via MTT5. In vivo evaluation of Tras-DXd-MTL1’s antitumor potency revealed a notably superior performance compared with the T-DXd (Tras-DXd) or Tras-MTL1 in immunocompetent mice with trastuzumab-resistant EMT6-HER2 tumor and immunodeficient mice with JIMT-1 tumor. This improved efficacy is primarily attributed to its dual functions of immune stimulation and cytotoxicity. Our findings highlight the potential of incorporating immunostimulatory agents into ADC design to potentiate antitumor effects and establish durable immune memory, thereby reducing tumor recurrence risks. Therefore, our study offers a novel strategy for the design of immune-activating ADCs and provides a potential approach for targeting solid tumors with different levels of HER2 expression.
Ruthenium Drug BOLD-100 Regulates BRAFMT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation
Authors: Griffin Daryl , Carson Robbie , Moss Debbie , Sessler Tamas , Lavin Deborah , Tiwari Vijay K. , Karelia Shivaali , Kennedy Richard , Savage Kienan I. , McDade Simon , Carie Adam , Pankovich Jim , Bazett Mark , Van Schaeybroeck Sandra 
Published: July 2024

Abstract
Patients with class I V600EBRAF-mutant (MT) colorectal cancer exhibit a poor prognosis, and their response to combined anti-BRAF/EGFR inhibition remains limited. An unmet need exits for further understanding the biology of V600EBRAFMT colorectal cancer. We used differential gene expression of BRAFWT and MT colorectal cancer cells to identify pathways underpinning BRAFMT colorectal cancer. We tested a panel of molecularly/genetically subtyped colorectal cancer cells for their sensitivity to the unfolded protein response (UPR) activator BOLD-100. To identify novel combination strategies for BOLD-100, we performed RNA sequencing and high-throughput drug screening. Pathway enrichment analysis identified significant enrichment of the UPR and DNA repair pathways in BRAFMT colorectal cancer. We found that oncogenic BRAF plays a crucial role in mediating the response to BOLD-100. Using a systems biology approach, we identified V600EBRAFMT-dependent activation of the replication stress response kinase ataxia telangiectasia and Rad3-related (ATR) as a key mediator of resistance to BOLD-100. Further analysis identified acute increases in BRAFMT-dependent-reactive oxygen species levels following treatment with BOLD-100, which promoted ATR/CHK1 activation and apoptosis. Furthermore, activation of reactive oxygen species/ATR/CHK1 following BOLD-100 was mediated through the AhR transcription factor and CYP1A1. Importantly, pharmacological blockade of this resistance pathway with ATR inhibitors synergistically increased BOLD-100-induced apoptosis and growth inhibition in BRAFMT models. These results highlight a possible novel therapeutic opportunity for BRAFMT colorectal cancer.
Implications: BOLD-100 induces BRAFMT-dependent replication stress, and targeted strategies against replication stress (e.g., by using ATR inhibitors) in combination with BOLD-100 may serve as a potential novel therapeutic strategy for clinically aggressive BRAFMT colorectal cancer.
Cardiovascular Disease, Genetic Susceptibility, and Risk of Psychiatric Disorders and Suicide Attempt: A Community‐Based Matched Cohort Study Based on the UK Biobank
Authors: Yang Jie , Zeng Yu , Yang Huazhen , Qu Yuanyuan , Han Xin , Chen Wenwen , Sun Yajing , Hu Yao , Ying Zhiye , Liu Di , Song Huan 
Published: July 2024

Background
The associations between cardiovascular disease (CVD) and multiple psychiatric disorders and suicide attempt, and whether different genetic susceptibilities affect such links, have not been investigated clearly.

Methods and Results
Based on the UK Biobank, we conducted a matched cohort study involving 63 923 patients who were first hospitalized with a CVD diagnosis between 1997 and 2020, and their 127 845 matched unexposed individuals. Cox models were used to examine the subsequent risk of psychiatric disorders and suicide attempt (ie, anxiety, depression, stress‐related disorder, substance misuse, psychotic disorder, and suicide behaviors) following CVD. We further performed stratified analyses by polygenic risk score for each studied psychiatric condition to detect the possible effects of genetic susceptibility on the observed associations. We found an increased risk of any psychiatric disorders and suicide attempt among CVD patients, compared with matched unexposed individuals, particularly within 1 year following the CVD (fully adjusted hazard ratio [HR] within 1 year, 1.83 [95% CI, 1.58–2.12]; HR after 1 year, 1.24 [95% CI, 1.16–1.32]). By subtype, the risk elevations existed for any psychiatric disorders and suicide attempt following most categories of CVDs. Analyses stratified by polygenic risk score revealed little impact of genetic predisposition to studied psychiatric conditions on these observed links.

Conclusions
Patients hospitalized for CVD were at increased subsequent risk of multiple types of psychiatric disorders and suicide attempt, especially in the first year after hospitalization, irrespective of their genetic susceptibilities to studied psychiatric conditions, and these findings underscore the necessity of developing timely psychological interventions for this vulnerable population.
Prognostic Implications of Resistive Reserve Ratio in Patients With Nonobstructive Coronary Artery Disease With Myocardial Bridging
Authors: Mahmoudi Hamidabad Negin , Kanaji Yoshihisa , Ozcan Ilke , Sara Jaskanwal Deep Singh , Ahmad Ali , Lerman Lilach O. , Lerman Amir 
Published: July 2024

Background
Myocardial bridging (MB) is accompanied by the dynamic extravascular compression of epicardial coronary arteries, leading to intracoronary hemodynamic disturbance with abnormal coronary flow profiles. We aimed to evaluate the prognostic implications of resistive reserve ratio (RRR), a composite measure of flow and pressure parameters that represents the vasodilatory capacity of the coronary arteries, in patients with angina with nonobstructive coronary artery disease (ANOCA) and MB, in comparison with coronary flow reserve (CFR).

Methods and Results

In this retrospective cohort study, we included patients with ANOCA who underwent coronary reactivity testing, where MB was identified by transient constriction in coronary artery segments between systole and diastole. Abnormal CFR and RRR were defined as <2.5 and <2.62, respectively. Major adverse cardiac events, including cardiovascular death, stroke, myocardial infarction, heart failure, and late revascularization, served as outcomes. Among 1251 patients with ANOCA, 191 (15.3%) had MB. The prevalence of abnormal CFR or RRR was not significantly different between patients with and without MB (
P
=0.144 and
P
=0.398, respectively). Over a median follow‐up time of 6.9 years, abnormal RRR predicted major adverse cardiac events in patients with MB (hazard ratio [HR], 4.38 [95% CI, 1.71–11.21];
P
=0.002) and without MB (HR, 1.91 [95% CI, 1.38–2.64];
P
<0.001). Abnormal CFR predicted major adverse cardiac events in patients without MB (HR, 2.15 [95% CI, 1.54–3.00];
P
<0.001), whereas it was not predictive of major adverse cardiac events in patients with MB (HR, 2.29 [95% CI, 0.93–5.65];
P
=0.073).

Conclusions
In patients with ANOCA and MB, impaired RRR was superior to impaired CFR in distinguishing patients at a higher risk of future adverse events, suggesting that RRR may serve as a risk stratification tool in patients with MB and ANOCA.
Sex Differences and Clinical Outcomes in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries: A Meta‐Analysis
Authors: Ang Song P. , Chia Jia E. , Krittanawong Chayakrit , Lee Kwan , Iglesias Jose , Misra Kanchan , Mukherjee Debabrata 
Published: July 2024

Background
Although myocardial infarction with nonobstructive coronary arteries (MINOCA) is more common in women, it is unknown whether sex is a risk factor for adverse outcomes in patients with MINOCA. We aimed to investigate the relationship between sex differences and outcomes of patients with MINOCA.

Methods and Results
A systematic literature search was performed in PubMed, Embase, and Cochrane databases from their inception until August 2023 for relevant studies. End points were pooled using the Hartung–Knapp–Sidik–Jonkman random‐effects model as odds ratio (OR) with 95% CIs. Nine studies, involving 30 281 patients with MINOCA (comprising 18 079 women and 12 202 men), were included in the study. Women were older and had a higher prevalence of hypertension, diabetes, and stroke compared with men. The median duration of follow‐up was 3.5 years, with an interquartile range of 2.2 to 4.2 years. Pooled analysis revealed no statistically significant difference in the risk of all‐cause mortality (OR, 1.03 [95% CI, 0.87–1.22]), major adverse cardiovascular events (OR, 1.18 [95% CI, 0.89–1.58]), heart failure (OR, 1.32 [95% CI, 0.57–3.03]), stroke (OR, 1.13 [95% CI, 0.56–2.26]), and myocardial infarction (OR, 1.04 [95% CI, 0.29–3.76]) between the 2 groups. Regarding short‐term outcomes, women had a significantly higher risk of in‐hospital major adverse cardiovascular events compared with men (OR, 1.33 [95% CI, 1.16–1.53]) whereas there was no significant difference in the risk of in‐hospital mortality (OR, 0.90 [95% CI, 0.64–1.28]) between the 2 patient groups.

Conclusions
Despite the differences in demographics and comorbidity profiles, there was no significant difference in the long‐term outcomes for patients with MINOCA between sexes. However, it is noteworthy that women experienced a higher risk of in‐hospital major adverse cardiovascular events compared with men.
Plasma Polyamines and Short‐Term Adverse Outcomes Among Patients With Ischemic Stroke: A Prospective Cohort Study
Authors: Yang Pinni , Shi Mengyao , Jia Yiming , Zhong Chongke , Peng Hao , Sun Lulu , Guo Daoxia , Chen Jing , Wang Aili , Xu Tan , Zhu Zhengbao , Zhang Yonghong , He Jiang 
Published: July 2024

Background
Polyamines have been reported to be associated with neurological function, but the associations between polyamines and the prognosis of ischemic stroke remain unclear. We aimed to prospectively investigate whether elevated plasma polyamine levels are associated with adverse outcomes in patients with ischemic stroke.

Methods and Results

Plasma polyamine levels were measured at admission in 3570 patients with acute ischemic stroke, and clinical outcomes were assessed at 3 months after stroke onset. The primary outcome was a composite outcome of death and major disability (modified Rankin Scale score≥3), and secondary outcomes included the individual outcomes of death and major disability. During a 3‐month follow‐up period, 877 participants (25.1%) experienced the primary outcome. Increased putrescines were associated with a decreased risk of the primary outcome (the highest versus the lowest tertile: odds ratio, 0.72 [95% CI, 0.58–0.91];
P
=0.005) and major disability (odds ratio, 0.59 [95% CI, 0.47–0.74];
P
<0.001). Conversely, increased spermidines were associated with an increased risk of death (hazard ratio, 1.86 [95% CI, 1.10–3.14];
P
=0.020), and increased spermines were associated with an increased risk of the primary outcome (odds ratio, 1.36 [95% CI, 1.08–1.71];
P
=0.009) and major disability (odds ratio, 1.27 [95% CI, 1.01–1.59];
P
=0.041).

Conclusions
Among patients with ischemic stroke, high plasma putrescine levels were associated with a decreased risk of adverse outcomes, whereas high plasma spermidine and spermine levels were associated with an increased risk of adverse outcomes. Further studies are needed to investigate whether targeting these polyamines can improve the prognosis of patients with ischemic stroke.

Registration

https://clinicaltrials.gov
. Identifier: NCT01840072.
Incidence and Outcomes of Cardiocerebral Infarction: A Cohort Study of 2 National Population-Based Registries
Authors: Ho Jamie Sin-Ying , Zheng Huili , Tan Benjamin Yong-Qiang , Ho Andrew Fu-Wah , Foo David , Foo Ling-Li , Lim Patrick Zhan-Yun , Liew Boon Wah , Ahmad Aftab , Chan Bernard P.L. , Chang Hui Meng , Kong Keng He , Young Sherry H. , Tang Kok Foo , Chua Terrance , Hausenloy Derek J. , Yeo Tiong-Cheng , Tan Huay-Cheem , Yip James W.L. , Chai Ping , Venketasubramanian Narayanaswamy , Chan Mark Yan-Yee , Yeo Leonard Leong-Litt , Sia Ching-Hui 
Published: July 2024

BACKGROUND:
Cardiocerebral infarction (CCI), which is concomitant with acute myocardial infarction (AMI) and acute ischemic stroke (AIS), is a rare but severe presentation. However, there are few data on CCI, and the treatment options are uncertain. We investigated the characteristics and outcomes of CCI compared with AMI or AIS alone.

METHODS:
We performed a retrospective cohort study of 120 531 patients with AMI and AIS from the national stroke and AMI registries in Singapore. Patients were categorized into AMI only, AIS only, synchronous CCI (same-day), and metachronous CCI (within 1 week). The primary outcome was all-cause mortality, and the secondary outcome was cardiovascular mortality. The mortality risks were compared using Cox regression. Multivariable models were adjusted for baseline demographics, clinical variables, and treatment for AMI or AIS.

RESULTS:

Of 127 919 patients identified, 120 531 (94.2%) were included; 74 219 (61.6%) patients had AMI only, 44 721 (37.1%) had AIS only, 625 (0.5%) had synchronous CCI, and 966 (0.8%) had metachronous CCI. The mean age was 67.7 (SD, 14.0) years. Synchronous and metachronous CCI had a higher risk of 30-day mortality (synchronous: adjusted HR [aHR], 2.41 [95% CI, 1.77–3.28]; metachronous: aHR, 2.80 [95% CI, 2.11–3.73]) than AMI only and AIS only (synchronous: aHR, 2.90 [95% CI, 1.87–4.51]; metachronous: aHR, 4.36 [95% CI, 3.03–6.27]). The risk of cardiovascular mortality was higher in synchronous and metachronous CCI than AMI (synchronous: aHR, 3.03 [95% CI, 2.15–4.28]; metachronous: aHR, 3.41 [95% CI, 2.50–4.65]) or AIS only (synchronous: aHR, 2.58 [95% CI, 1.52–4.36]; metachronous: aHR, 4.52 [95% CI, 2.95–6.92]). In synchronous CCI, AMI was less likely to be managed with PCI and secondary prevention medications (
P
<0.001) compared with AMI only.

CONCLUSIONS:
Synchronous CCI occurred in 1 in 200 cases of AIS and AMI. Synchronous and metachronous CCI had higher mortality than AMI or AIS alone.
Unveiling the Unspoken and Invisible: Analyzing Artistic Responses to Radiophobia
Authors: Gajda Kinga Anna 
Published: July 2024

Abstract
The persistent nuclear threat continues to loom large, particularly in the contemporary landscape shaped by the ongoing Russian-Ukrainian war, often referred to as the Second Cold War. This conflict has drawn global attention and triggered an upsurge in nuclear discourse within the media, leading to a resurgence of radiophobia. This article aims to introduce the works of several artists who have undertaken the challenging task of rendering visible the imperceptible, ensuring that the nuclear threat and the repercussions of radiation are not relegated to oblivion.
Simulated brain networks reflecting progression of Parkinson’s disease
Authors: Jung Kyesam , Eickhoff Simon B. , Caspers Julian ,   UKD-PD team, Popovych Oleksandr V. 
Published: July 2024

Abstract
The neurodegenerative progression of Parkinson’s disease affects brain structure and function and, concomitantly, alters the topological properties of brain networks. The network alteration accompanied by motor impairment and the duration of the disease has not yet been clearly demonstrated in the disease progression. In this study, we aim to resolve this problem with a modeling approach using the reduced Jansen-Rit model applied to large-scale brain networks derived from cross-sectional MRI data. Optimizing whole-brain simulation models allows us to discover brain networks showing unexplored relationships with clinical variables. We observe that the simulated brain networks exhibit significant differences between healthy controls (n = 51) and patients with Parkinson’s disease (n = 60) and strongly correlate with disease severity and disease duration of the patients. Moreover, the modeling results outperform the empirical brain networks in these clinical measures. Consequently, this study demonstrates that utilizing the simulated brain networks provides an enhanced view of network alterations in the progression of motor impairment and identifies potential biomarkers for clinical indices.
Aristotle’s On the Good and the “Categorial Reduction Argument”
Authors: Granieri Roberto 
Published: July 2024

Abstract
Alexander of Aphrodisias reports a series of arguments from Aristotle’s Περὶ τἀγαθοῦ purportedly deployed by Plato to defend his doctrine of principles. One of these arguments, the so-called “categorial reduction argument”, underpins the postulation of the two first principles, the One and the Great and Small, through a bipartition of all beings into two categories, labeled ‘in themselves’ and ‘opposites’. I scrutinize this argument and compare it with other Early Academic bicategorial divisions and especially with the tripartite categorial distinction, itself apparently based on material of Early Academic provenance, included in Sextus Empiricus’ Adversus Physicos 2.262-275. I argue that the Περὶ τἀγαθοῦ account of the “categorial reduction argument” leaves open certain philosophical problems, and Sextus’ report is best interpreted, rather than as a more detailed version of that account (as a common view would have it), as an alternative formulation of it that incorporates a philosophical attempt to disentangle those problems.
Between the Real and Ideal: Efficacy in an Ancient Mesopotamian Building Ritual
Authors: Gabbay Uri , Susnow Matthew 
Published: July 2024

Abstract
This article investigates how ritual transforms the ordinary into something extraordinary. It is the capacity of ritual to differentiate, and to be differentiated from other activities, that provides a group with a framework for seeing what they are doing as being meaningfully different than ordinary. Without the proper focusing lens – ritualization – special nonordinary acts and objects can look very mundane indeed. Furthermore, there is often a stark contrast between what ritual actually does, and what is claimed is being done. This study analyzes a first millennium BCE ritual from Mesopotamia – attested both archaeologically and textually – that deals with preparing and manufacturing various materials and paraphernalia necessary for laying a temple’s foundations, to underscore (1) the fundamental utility of these notions in broadly studying ritual, (2) the processes and mechanisms that transform ordinary materials into special, perhaps “sacred,” products, and (3) how ritual merges the gap between the real and ideal.
How about Pantheism in Ancient Greek Religion?
Authors: Pakkanen Petra 
Published: July 2024

Abstract
Ancient Greek religion has been very rarely studied with reference to pantheism. This article proposes that we should introduce pantheism as an additional interpretive strategy to understand Greek religion. This presupposes addressing the relationship between the interpretations of doxa (theology), discussion about the nature of divine unity in antiquity (philosophy), and religious cult praxis. The main conceptual arguments underlined in refutations of pantheism are discussed. This is followed by a brief survey of the more frequently discussed monotheism and henotheism in Greek religion. The main part of the article presents pantheistic trends in Greek religion, including philosophical argumentation, pantheistic expressions in mythology and in cultic life. It is found that Greek religion exhibits views that can be regarded as pantheistic: gods were immanent rather than transcendent, everything could potentially participate in divine reality, and the boundaries between divine, human, and nature were not exclusive but permeable and fluid.
God Is Time; The Devil Rules over Space
Authors: Berzal de Dios Jimena 
Published: July 2024

Abstract
This article explores José Val del Omar’s religious thought in relation to his Fire in Castile, a 1960 experimental film that sets Spanish Renaissance sculptures in motion by use of pulsating lights, projected patterns, and other striking audiovisual effects. Val del Omar sought to provoke a new and technological mystical encounter: Fire in Castile displaces the viewers’ physical space to create a transcendental and sacred opening, in turn activating the affective role of the sculptures. This essay seeks to contextualize the film in relation to a core theological notion in Val del Omar’s thought, the interlacing of God and time: “God is Time,” he wrote, “the devil rules over space.” For Val del Omar, this is a tragic situation in which God is waiting for us in the entrails of life, which in turn demands a visceral disruption of our spatiotemporal and existential assumptions.