bluuebunny/crossref_metadata_2025_split huggingface dataset:
When up brings you down: The effects of imagined vertical movements on motivation, performance, and consumer behavior
Authors: Ostinelli Massimiliano , Luna David , Ringberg Torsten 
Published: December 2013

AbstractPrevious embodied cognition research suggests that “up” is associated with positivity (e.g., good, divine), whereas “down” is associated with negativity (e.g., bad, evil). We focus on the effect of vertical movements on consumer behavior and go beyond investigating mere affective associations of verticality. In five studies, we provide evidence that the mental simulation of vertical movements has counterintuitive effects on behavior—that is, imagining moving up hampers motivation and performance by boosting self‐worth. A pilot study shows that the imagination of vertical movements affects self‐worth. Studies 1, 2 and 3 show that imagining upward movements (e.g., taking an elevator ride up or taking off in an airplane) diminishes motivation as well as performance. Studies 4 and 5 show that imagining moving upward (downward) makes people feel better (worse) about themselves which, in turn, decreases (increases) their motivation to succeed on a subsequent task, hence worsening (improving) performance. This occurs independently of respondents' mood.
PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1
Authors: Ebi Hiromichi , Costa Carlotta , Faber Anthony C. , Nishtala Madhuri , Kotani Hiroshi , Juric Dejan , Della Pelle Patricia , Song Youngchul , Yano Seiji , Mino-Kenudson Mari , Benes Cyril H. , Engelman Jeffrey A. 
Published: December 2013

SignificanceGenetic alterations targeting the PI3K pathway are highly prevalent in breast cancers. Although breast cancers harboringPIK3CAmutation andHER2amplification have enhanced sensitivity to PI3K inhibitors, the mechanism underlying this sensitivity is unknown. This study shows that PI3K inhibitors suppress MEK/ERK pathway in these cancers, and inhibition of both AKT and ERK pathways is necessary for maximal antitumoral activity. We elucidate a unique mechanistic link between PI3K and ERK via PI3K-dependent regulation of P-Rex1, which in turn regulates the Rac1/PAK/c-RAF/MEK/ERK pathway. Importantly, expression levels of the Rac-GEF, P-Rex1, correlate with sensitivity to PI3K inhibitors among these breast cancer cell lines, indicating its potential utility as a biomarker to identify cancers that will respond to PI3K inhibitors.
Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway
Authors: Hong Elim , Santhakumar Kirankumar , Akitake Courtney A. , Ahn Sang Jung , Thisse Christine , Thisse Bernard , Wyart Claire , Mangin Jean-Marie , Halpern Marnie E. 
Published: December 2013

Significance
The forebrain habenular nuclei (Hb) and their connections to the midbrain interpeduncular nucleus (IPN) have emerged as a valuable model to study left-right differences in the zebrafish brain. However, whether this pathway is enriched in the neurotransmitter acetylcholine and involved in nicotine addiction as in mammals is unresolved. We discovered a duplicated cholinergic gene locus that is predominantly expressed in the right Hb at larval stages. Through electrophysiology and pharmacology, we show that this asymmetrical cholinergic pathway is functional. Moreover, specific nicotinic acetylcholine receptor subunits localize to the same subregions of the IPN that are activated by exposure of adults to nicotine. Our study firmly establishes the zebrafish as a valid model to study how Hb-IPN circuitry influences nicotine addiction.
Forage Fish Interactions: a symposium on “Creating the tools for ecosystem-based management of marine resources”
Authors: Peck Myron A. , Neuenfeldt Stefan , Essington Timothy E. , Trenkel Verena M. , Takasuka Akinori , Gislason Henrik , Dickey-Collas Mark , Andersen Ken H. , Ravn-Jonsen Lars , Vestergaard Niels , Kvamsdal Sturla F. , Gårdmark Anna , Link Jason , Rice Jake C. 
Published: December 2013

Abstract
Peck, M. A., Neuenfeldt, S., Essington, T. E., Trenkel, V. M., Takasuka, A., Gislason, H., Dickey-Collas, M., Andersen, K. H., Ravn-Jonsen, L., Vestergaard, N., Kvamsdal, S., Gårdmark, A., Link, J., and Rice, J. Forage Fish Interactions: a symposium on “Creating the tools for ecosystem-based management of marine resources”. – ICES Journal of Marine Science, 71: . Forage fish (FF) have a unique position within marine foodwebs and the development of sustainable harvest strategies for FF will be a critical step in advancing and implementing the broader, ecosystem-based management of marine systems. In all, 70 scientists from 16 nations gathered for a symposium on 12–14 November 2012 that was designed to address three key questions regarding the effective management of FF and their ecosystems: (i) how do environmental factors and predator–prey interactions drive the productivity and distribution of FF stocks across ecosystems worldwide, (ii) what are the economic and ecological costs and benefits of different FF management strategies, and (iii) do commonalities exist across ecosystems in terms of the effective management of FF exploitation?
Effect of Germination and UV‐C Radiation on the Accumulation of Flavonoids and Saponins in Black Bean Seed Coats
Authors: Guajardo‐Flores Daniel , Serna‐Guerrero Delia , Serna‐Saldívar Sergio O. , Jacobo‐Velázquez Daniel A. 
Published: December 2013

ABSTRACTIn the present study, we evaluated UV‐C radiation and germination treatments as an approach to increase the concentration of bioactive molecules in black bean seed coats. Black beans were germinated for 20 h under UV‐C radiation. Germination rate was higher in seeds radiated with UV‐C light compared with the control (nonirradiated seeds). Flavonoid content was increased twofold in seed coats of beans germinated for 10 h under UV‐C compared with the control. Quercetin‐3O‐glucoside was the major flavonoid identified in stressed seed coats. Furthermore, the application of UV‐C radiation during germination increased the content of soyasaponin Af, Ba, and αg, and it induced the de novo biosynthesis of soyasaponins (phaseoside I, soyasaponin deacetyl Af, and soyasaponin deactyl Ah) not present in the control. Germination of black beans under UV‐C radiation was an effective and simple approach to increase the concentration of bioactive molecules in black bean seed coats.
South-South Cooperation
Authors: Tilak Jandhyala 
Published: December 2013

Purpose– India is described as an emerging donor. Actually India has started providing development assistance to developing countries immediately after independence. The amount of aid was relatively small, but grew over the years to a recognisable size. The purpose of this paper is to review the long experience of India in the framework of development assistance which is laid in the foundational principles of South-South Development Cooperation (SSDC).Design/methodology/approach– Based on secondary data, the paper provides an exhaustive account of India's programme of development assistance, and a critical discussion of issues involved.Findings– The analysis shows that given certain unique features of its aid programme, India has a great potential to emerge as a major donor country, and even to rank among big traditional donor countries. It can also influence the global aid architecture. There are many lessons that others can learn from the “Indian model of aid”. However, there are certain problems and challenges that India has to address for it to become a major international player in the aid business. One of the most important problems refers to the absence of detailed information.Research limitations/implications– The available details on India's assistance are sketchy and confusing; there are no detailed and consolidated statements of assistance; and it is only now a proper formal agency to coordinate all external assistance and to provide effective management in a cohesive manner has been set up.Originality/value– The analytical and critical account of India's aid programme presented here is hoped to provide valuable fresh insights to the whole issue and should be of considerable academic and policy value.
Comparison of LTCC inductors on different substrate configurations with PCB inductor
Authors: M. Maric Andrea , J. Radosavljevic Goran , Smetana Walter , D. Zivanov Ljiljana 
Published: December 2013

Purpose
– This paper presents performance comparison of RF inductors with the same lateral geometry applying different substrate configurations. The purpose of presented research is to demonstrate and verify some advantages of low temperature co-fired ceramic (LTCC) technology in comparison to printed circuit board (PCB) technology based on the performance analysis of presented inductors in lower RF range.

Design/methodology/approach
– The presented inductors are meander structures fabricated in LTCC and PCB technology, with same line width and outer dimensions. Performance analysis of all configurations is based on measurement results and numerical simulations. Advantage of LTCC technology is demonstrated by application of substrate pattering in order to maintain and/or improve expected inductor performances.

Findings
– As expected, obtained results for the inductor with an air-gap show increase of the quality factor over 30 percent and widening of the operating frequency range by 50 percent when compared with the same LTCC structure without a gap. But what is more important the inductor with air-gap embedded inside LTCC stack maintains efficiency when compared to PCB inductor. This fact offers possibility of integration good quality components inside LTCC stack and reduction of used chip space.

Originality/value
– Advantages of LTCC with respect to PCB design are demonstrated by efficiency increase of the proposed inductor configurations by means of design optimization relying on substrate pattering and incensement of the packaging density by embedding inductors. The presented findings are verified through consistency of measurement results and simulated data.
Evaluation of the European tick‐borne encephalitis vaccine against Omsk hemorrhagic fever virus
Authors: Chidumayo Nozyechi N. , Yoshii Kentaro , Kariwa Hiroaki 
Published: December 2013

ABSTRACTThis study focused on the antigenic cross‐reactivity between tick‐borne encephalitis virus (TBEV) and Omsk hemorrhagic fever virus (OHFV) to assess the efficacy of the commercial TBE vaccine against OHFV infection. Neutralization tests performed on sera from OHFV‐ and TBEV‐infected mice showed that neutralizing antibodies are cross‐protective. The geometric mean titers of antibodies against TBEV and OHFV from TBEV‐infected mice were similar. However, the titers of anti‐TBEV antibodies in OHFV‐infected mice were significantly lower than those of anti‐OHFV antibodies in the same animals. In mouse vaccination and challenge tests, the TBE vaccine provided 100% protection against OHFV infection. Eighty‐six percent of vaccinees seroconverted against OHFV following complete vaccination, and the geometric mean titers of neutralizing antibodies against OHFV were comparable to those against TBEV. These data suggest that the TBE vaccine can prevent OHFV infection.
An insightful parametrization for the flatlander's interpretation of time‐lapsed seismic data
Authors: Alvarez Erick , MacBeth Colin 
Published: December 2013

ABSTRACTAn approximation is developed that allows mapped 4D seismic amplitudes and time‐shifts to be related directly to the weighted linear sum of pore pressure and saturation changes. The weights in this relation are identified as key groups of parameters from a petroelastic model and include the reservoir porosity. This dependence on groups of parameters explains the inherent non‐uniqueness of this problem experienced by previous researchers. The proposed relation is of use in 4D seismic data feasibility studies and inversion and interpretation of the 4D seismic response in terms of pore pressure and water saturation changes. A further result is drawn from analysis of data from the North Sea and West Africa, which reveals that the relative interplay between the effects of pore pressure and saturation changes on the seismic data can be simplified to the control of a single, spatially variant parameter CS/CP. Combining these results with those from published literature, we find that CS/CP = 8 appears to be a generality across a range of clastic reservoirs with a similar mean porosity. Using this CS/CP value, an in situ seismic‐scale constraint for the rock stress sensitivity component of the petroelastic model is constructed considering this component carries the largest uncertainty.
Thermal Inactivation of Escherichia coli O157:H7 in Strawberry Puree and Its Effect on Anthocyanins and Color
Authors: Hsu Hsin‐Yun , Huang Lihan , Wu James Swi‐Bea 
Published: December 2013

AbstractRaw whole strawberries, if contaminated with pathogens, such as Escherichia coli O157:H7, must be pasteurized prior to consumption. Therefore, the objective of this research was to investigate the thermal inactivation kinetics of E. coli O157:H7 in strawberry puree (SP), and evaluate the changes in anthocyanins and color, and the survival of yeasts and molds (YM) after thermal processing. Inoculated with a 5‐strain cocktail, fresh SP, with or without added sugar (20 and 40 °Brix), was heated at 50, 52, 54, 57.5, 60, and 62.5 °C to determine the thermal resistance of E. coli O157:H7. In raw SP, the average D‐values of E. coli O157:H7 were 909.1, 454.6, 212.8, 46.1, and 20.2 s at 50, 52, 54, 57.5, and 60 °C, respectively, with a z‐value of 5.9 °C. While linearly decreasing with temperature, the log D‐values of E. coli O157:H7 increased slightly with sugar concentration. The log degradation rates of anthocyanins increased linearly with temperature, but decreased slightly with sugar concentrations. These results suggest that sugar may provide some protection to both E. coli O157: H7 and anthocyanins in SP. The browning index was not affected by heating at 50 and 52 ºC at low sugar concentrations, but increased by an average of 1.28%, 2.21%, and 10.1% per min when SP was exposed to heating at 54, 57.5, and 60 °C, respectively. YM was also inactivated by heating. This study demonstrated that properly designed thermal processes can effectively inactivate E. coli O157:H7 and YM in contaminated SP, while minimizing the changes in anthocyanins and color.
Combination of degradation pathways for naphthalene utilization in Rhodococcus sp. strain TFB
Authors: Tomás‐Gallardo Laura , Gómez‐Álvarez Helena , Santero Eduardo , Floriano Belén 
Published: December 2013

SummaryRhodococcus sp. strain TFB is a metabolic versatile bacterium able to grow on naphthalene as the only carbon and energy source. Applying proteomic, genetic and biochemical approaches, we propose in this paper that, at least, three coordinated but independently regulated set of genes are combined to degrade naphthalene in TFB. First, proteins involved in tetralin degradation are also induced by naphthalene and may carry out its conversion to salicylaldehyde. This is the only part of the naphthalene degradation pathway showing glucose catabolite repression. Second, a salicylaldehyde dehydrogenase activity that converts salicylaldehyde to salicylate is detected in naphthalene‐grown cells but not in tetralin‐ or salicylate‐grown cells. Finally, we describe the chromosomally located nag genes, encoding the gentisate pathway for salicylate conversion into fumarate and pyruvate, which are only induced by salicylate and not by naphthalene. This work shows how biodegradation pathways in Rhodococcus sp. strain TFB could be assembled using elements from different pathways mainly because of the laxity of the regulatory systems and the broad specificity of the catabolic enzymes.
Biotransformation of the high‐molecular weight polycyclic aromatic hydrocarbon (PAH) benzo[k]fluoranthene by Sphingobium sp. strain KK22 and identification of new products of non‐alternant PAH biodegradation by liquid chromatography electrospray ionization tandem mass spectrometry
Authors: Maeda Allyn H. , Nishi Shinro , Hatada Yuji , Ozeki Yasuhiro , Kanaly Robert A. 
Published: December 2013

SummaryA pathway for the biotransformation of the environmental pollutant and high‐molecular weight polycyclic aromatic hydrocarbon (PAH) benzo[k]fluoranthene by a soil bacterium was constructed through analyses of results from liquid chromatography negative electrospray ionization tandem mass spectrometry (LC/ESI(–)‐MS/MS). Exposure of Sphingobium sp. strain KK22 to benzo[k]fluoranthene resulted in transformation to four‐, three‐ and two‐aromatic ring products. The structurally similar four‐ and three‐ring non‐alternant PAHs fluoranthene and acenaphthylene were also biotransformed by strain KK22, and LC/ESI(–)‐MS/MS analyses of these products confirmed the lower biotransformation pathway proposed for benzo[k]fluoranthene. In all, seven products from benzo[k]fluoranthene and seven products from fluoranthene were revealed and included previously unreported products from both PAHs. Benzo[k]fluoranthene biotransformation proceeded through ortho‐cleavage of 8,9‐dihydroxy‐benzo[k]fluoranthene to 8‐carboxyfluoranthenyl‐9‐propenic acid and 9‐hydroxy‐fluoranthene‐8‐carboxylic acid, and was followed by meta‐cleavage to produce 3‐(2‐formylacenaphthylen‐1‐yl)‐2‐hydroxy‐prop‐2‐enoic acid. The fluoranthene pathway converged with the benzo[k]fluoranthene pathway through detection of the three‐ring product, 2‐formylacenaphthylene‐1‐carboxylic acid. Production of key downstream metabolites, 1,8‐naphthalic anhydride and 1‐naphthoic acid from benzo[k]fluoranthene, fluoranthene and acenaphthylene biotransformations provided evidence for a common pathway by strain KK22 for all three PAHs through acenaphthoquinone. Quantitative analysis of benzo[k]fluoranthene biotransformation by strain KK22 confirmed biodegradation. This is the first pathway proposed for the biotransformation of benzo[k]fluoranthene by a bacterium.
Hypomethylation of long interspersed nucleotide element‐1 in peripheral mononuclear cells of juvenile systemic lupus erythematosus patients in China
Authors: Huang Xiaolan , Su Gaixiu , Wang Zhen , Shangguan Shaofang , Cui Xiaodai , Zhu Jia , Kang Min , Li Shengnan , Zhang Ting , Wu Fengqi , Wang Li 
Published: December 2013

AbstractAimMethylation abnormalities in T lymphocytes have been reported to correlate with systemic lupus erythematosus (SLE). Previous studies identified hypomethylation in the promoter of several genes linked to SLE. Long interspersed nucleotide element‐1 (LINE‐1) constitutes 17–25% of the human genome, and LINE‐1 hypomethylation has been reported in SLE. Limited information is available regarding LINE‐1 methylation in juvenile SLE (JSLE).MethodMethylation levels of LINE‐1 in peripheral blood mononuclear cells (PBMCs) from 59 JSLE and 47 control samples were examined by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry. Total homocysteine (tHcy) concentrations in plasma were measured by immunoassay.ResultsSignificant hypomethylation of LINE‐1 was observed in PBMCs from JSLE patients (60.93% in cases compared with 62.88% in controls, P = 0.001). Significant LINE‐1 hypomethylation was observed in active SLE compared to controls (60.66% vs. 62.88%, P = 0.001). According to other clinical parameters, a significant correlation was found between LINE‐1 methylation levels and the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI‐2000) of the cases (r = −0.285, P = 0.032). The risk of JSLE increased with decreasing levels of LINE‐1 methylation, with an odds ratio of 14.5 (95% CI: 2.8–75.6, P = 0.002). Cases had significantly higher plasma concentrations of tHcy than controls (15.11 vs. 11.02 μmol/L, P = 0.028); the correlation between LINE‐1 methylation levels and tHcy was significant (r = −0.4, P = 0.013). Correlations between methylation levels of LINE‐1 and complement component 3 were significant (r = 0.317, P = 0.044; r = 0.387, P = 0.031, in total JSLE and active JSLE, respectively).ConclusionHypomethylation of LINE‐1 is associated with risk of JSLE, and LINE‐1 methylation levels were related to disease activity and clinical manifestations. The correlation between tHcy levels and LINE‐1 methylation was significant.
Ten‐year review of gastrointestinal stromal tumours at a tertiary referral hospital in New Zealand
Authors: Siu Joey , Lim Michael , Fischer Jesse , Dobbs Bruce , Wakeman Chris , Ing Andrew , Frizelle Frank 
Published: December 2013

AbstractBackgroundGastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract and make up 1–2% of all gastrointestinal malignancies. Traditionally, the treatment of choice for primary disease is surgical resection; however, no single surgeon or institution gets extensive exposure to these patients so appropriate decision‐making is difficult, particularly since the introduction of the tyrosine kinase inhibitor imatinib, which has become an important additional management tool.MethodAll patients were diagnosed and treated for GISTs in Christchurch Hospital (Christchurch, New Zealand) between 1 January 2000 and 31 December 2010. We maintain a prospective database of all patients with GISTs. Data on clinical and histopathological variables, management and survival outcomes were recorded. These were then reviewed.ResultsThere were 93 patients in this study. Fifty were women. Median age was 69 (interquartile range (IQR) 59–76) years. Fifty‐one tumours were located in the stomach, 27 in the small bowel, six in the colon, three in the oesophagus, one in the rectum and five were extra‐gastrointestinal. In total, 22 patients received imatinib therapy; four patients with metastatic disease had imatinib as sole therapy. The median follow‐up was 58 (IQR 30–90) months. The 5‐year overall survival and disease‐free survival (DFS) for the entire study population was 69% and 64%, respectively. The 5‐year DFS was higher for all patients who have localized disease when compared with those who have metastatic disease (76% versus 28%, P‐value 0.001).ConclusionSurgery aiming at an R0 resection remains the mainstay of treatment. We propose the most effective way to grow the knowledge base in New Zealand is the establishment of a national register, thereby allowing better clinical decision‐making by interpretation of a larger data set.