bluuebunny/crossref_metadata_2025_split huggingface dataset:
Certain algebraic surfaces with Eisenbud‐Harris general fibration of genus 4
Authors: Takahashi Tomokuni 
Published: November 2012

AbstractWe classify the algebraic surfaces with Eisenbud‐Harris general fibration of genus 4 over a rational curve or an elliptic curve whose slope attains the lower bound. The classification of our surfaces is strongly related to the result of the classification for certain relative quadric hypersurfaces in 3‐dimensional projective space bundles over a rational curve and an elliptic curve. We further prove some results about the canonical maps, the quadric hulls of the canonical images and the deformation for these surfaces.
Suppressing the formation of lipid raft‐associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF‐1α‐induced invasion of human esophageal carcinoma cells
Authors: Lin Meng‐Liang , Lu Yao‐Cheng , Chen Hung‐Yi , Lee Chuan‐Chun , Chung Jing‐Gung , Chen Shih‐Shun 
Published: November 2012

AbstractStromal cell‐derived factor‐1α (SDF‐1α) is a ligand for C‐X‐C chemokine receptor type 4 (CXCR4), which contributes to the metastasis of cancer cells by promoting cell migration. Here, we show that the SDF‐1α/CXCR4 axis can significantly increase invasion of esophageal carcinoma (EC) cells. We accomplished this by examining the effects of CXCR4 knockdown as well as treatment with a CXCR4‐neutralizing antibody and the CXCR4‐specific inhibitor AMD3100. Curcumin suppressed SDF‐1α‐induced cell invasion and matrix metalloproteinase‐2 (MMP‐2) promoter activity, cell surface localization of CXCR4 at lipid rafts, and lipid raft‐associated ras‐related C3 botulinum toxin substrate 1 (Rac1)/phosphatidylinositol 3‐kinase (PI3K) p85α/Akt signaling. Curcumin inhibited SDF‐1α‐induced cell invasion by suppressing the Rac1–PI3K signaling complex at lipid rafts but did not abrogate lipid raft formation. We further demonstrate that the attenuation of lipid raft‐associated Rac1 activity by curcumin was critical for the inhibition of SDF‐1α‐induced PI3K/Akt/NF‐κB activation, cell surface localization of CXCR4 at lipid rafts, MMP‐2 promoter activity, and cell invasion. Collectively, our results indicate that curcumin inhibits SDF‐1α‐induced EC cell invasion by suppressing the formation of the lipid raft‐associated Rac1‐PI3K‐Akt signaling complex, the localization of CXCR4 with lipid rafts at the cell surface, and MMP‐2 promoter activity, likely through the inhibition of Rac1 activity. © 2012 Wiley Periodicals, Inc.
Successful delayed reconstruction of common peroneal neuroma‐in‐continuity using sural nerve graft
Authors: Reichl Heike , Ensat Florian , Dellon A. Lee , Wechselberger Gottfried 
Published: November 2012

AbstractInjuries of the common peroneal nerve (CPN) are frequent and associated with poor motor outcomes. So far, the opinion is held, that nerve reconstruction is reasonable and indicated up to 6 months after injury. We describe successful sural nerve interposition grafting in a patient with neuroma‐in‐continuity formation of the CPN, presenting with foot drop, 13 months after injury. Due to this positive result, we think nerve grafting in neuroma‐in‐continuity lesions of the CPN should be contemplated in patients with foot drop even more than one year after injury. © 2012 Wiley Periodicals, Inc. Microsurgery, 2013.
Rsf‐1, a chromatin remodelling protein, interacts with cyclin E1 and promotes tumour development
Authors: Sheu Jim Jinn‐Chyuan , Choi Jung Hye , Guan Bin , Tsai Fuu‐Jen , Hua Chun‐Hung , Lai Ming‐Tsung , Wang Tian‐Li , Shih Ie‐Ming 
Published: November 2012

AbstractChromosome 11q13.5 containing RSF1 (HBXAP), a gene involved in chromatin remodelling, is amplified in several human cancers including ovarian carcinoma. Our previous studies demonstrated requirement of Rsf‐1 for cell survival in cancer cells, which contributed to tumour progression; however, its role in tumourigenesis has not yet been elucidated. In this study, we co‐immunoprecipitated proteins with Rsf‐1 followed by nanoelectrospray mass spectrometry and identified cyclin E1, besides SNF2H, as one of the major Rsf‐1 interacting proteins. Like RSF1, CCNE1 is frequently amplified in ovarian cancer, and both Rsf‐1 and cyclin E1 were found co‐up‐regulated in ovarian cancer tissues. Ectopic expression of Rsf‐1 and cyclin E1 in non‐tumourigenic TP53mut RK3E cells led to an increase in cellular proliferation and tumour formation by activating cyclin E1‐associated kinase (CDK2). Tumourigenesis was not detected if either cyclin E1 or Rsf‐1 was expressed, or they were expressed in a TP53wt background. Domain mapping showed that cyclin E1 interacted with the first 441 amino acids of Rsf‐1. Ectopic expression of this truncated domain significantly suppressed G1/S‐phase transition, cellular proliferation, and tumour formation of RK3E‐p53R175H/Rsf‐1/cyclin E1 cells. The above findings suggest that Rsf‐1 interacts and collaborates with cyclin E1 in neoplastic transformation and TP53 mutations are a prerequisite for tumour‐promoting functions of the RSF/cyclin E1 complex.
Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms
Authors: Villa Luigi , Boor Peter , Konieczny Andrzej , Kunter Uta , van Roeyen Claudia RC , Denecke Bernd , Gan Lin , Neusser Matthias A , Cohen Clemens D ,   For the ERCB Consortium;, Eitner Frank , Scholl Thomas , Ostendorf Tammo , Floege Jürgen 
Published: November 2012

AbstractMesangioproliferative glomerulonephritis is the most common nephritis worldwide. We examined the effects of low‐ and high‐dose telmisartan, an angiotensin II receptor blocker, in rats with progressive anti‐Thy1.1 mesangioproliferative glomerulonephritis in a clinically relevant situation of established renal damage. Uninephrectomized nephritic rats were randomized on day 28 to remain untreated (control treatment; CT), or to receive low‐ (0.1 mg/kg/day, LT) or high‐dose telmisartan (10 mg/kg/day, HT), hydrochlorothiazide + hydralazine (8 + 32 mg/kg/day, HCT + H), or atenolol (100 mg/kg/day, AT). CT and LT rats were hypertensive, whereas HT, HCT + H and AT treatment normalized blood pressures. On day 131, despite similar blood lowering effects, only HT, but not AT or HCT + H, prevented loss of renal function and reduced proteinuria compared to CT. Only HT potently ameliorated glomerulosclerosis, tubulointerstitial damage, cortical matrix deposition, podocyte damage and macrophage infiltration. HT reduced cortical expression of platelet derived growth factor receptor‐α and ‐β as well as transforming growth factor‐β1. LT exhibited minor but significant efficacy even in the absence of antihypertensive effects. Transcript array analyses revealed a four‐fold down‐regulation of renal cortical chemokine (C–C motif) receptor 6 (CCR6) mRNA by HT, which was confirmed at the protein level. Silencing of CCR6 did not alter podocyte function in vitro, thus indicating a predominant role in the tubulo‐interstitium. In human kidney biopsies, CCR6 mRNA and mRNA of its ligand chemokine (C–C motif) ligand 20 was up‐regulated in patients with progressive IgA nephropathy compared to stable disease. Thus, delayed treatment with high‐dose telmisartan exerted a pronounced benefit in progressive mesangioproliferative glomerulonephritis, which extended beyond that of equivalent blood pressure lowering. We identified down‐regulation of platelet‐derived growth factor receptors and CCR6 as potential mediators of telmisartan‐related renoprotection. CCR6 may also regulate the renal outcome in human mesangioprolfierative glomerulonephritis. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Treatment of high risk Sertoli–Leydig cell tumors of the ovary using a gonadotropin releasing hormone (GnRH) analog
Authors: Lashkari Harsha Prasada , Nash Ruth , Albanese Assunta , Okoye Bruce , Millar Robert , Pritchard‐Jones Kathy 
Published: November 2012

AbstractSertoli–Leydig cell tumors are rare ovarian neoplasms. We report two unusual cases with bilateral SLCTs suggesting evidence of genetic predisposition and at high risk of recurrence. To reduce this risk, we exploited the use of GnRH analog to lower gondadotropin and potentially directly inhibit the tumors through expressed GnRH receptors. We used it as maintenance antitumor therapy for 2 years after completion of chemotherapy, to cover the period of risk for recurrence. Both patients remain in complete remission at >2 years after completing leuprorelin therapy. Of note, both patients carry DICER1 mutations, frequently found in pleuropulmonary blastoma syndrome. Pediatr Blood Cancer 2013; 60: E16–E18. © 2012 Wiley Periodicals, Inc.
Investigation of acrylamide‐modified melamine‐formaldehyde resins as a compatibilizer for kenaf‐unsaturated polyester composites
Authors: Ren Xiaofeng , Li Chunhong , Li Kaichang 
Published: November 2012

AbstractKenaf fiber‐reinforced unsaturated polyester (UPE) composites were prepared by compression molding. A novel compatibilizer was prepared from melamine, formaldehyde, and acrylamide. The treatment of kenaf fibers with the compatibilizer significantly increased the flexural properties and reduced the water uptake of the resulting kenaf–UPE composites. The effects of the total solids content, the molar ratios of melamine/formaldehyde/acrylamide, and the pH value of the compatibilizer solution in the treatment of kenaf fibers on the flexural strength, flexural modulus, as well as the water uptake of the kenaf–UPE composites were studied in detail. Fourier transform infrared spectra revealed that the compatibilizer was covalently bonded to kenaf fibers. Scanning electron microscopy images of the fractured kenaf–UPE composites confirmed that the treatment of kenaf fibers with the compatibilizer improved the interfacial adhesion between kenaf fibers and UPE resin. The mechanisms for the improved flexural properties and the reduced water uptake by the treatments of the kenaf fibers were proposed and discussed. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers
Preparation and characterization of polyaniline nanofiber colloids
Authors: Qiu Wei , Ma Li , Gan Mengyu , Bai Youqian , Fu Dandan , Li Zhitao , Chen Feifei 
Published: November 2012

AbstractPolyaniline (PANI) nanofibers were prepared via the reaction of aniline with ammonium persulfate carried out in ethylene glycol (EG) medium without water. These purified PANI nanofibers could be dispersed in water and other polar solvents, such as ethanol, EG, and N,N‐dimethylformamide, to form colloids. The morphology and structure of the PANI nanofibers were characterized and the effects of mechanical stirring on the morphology, structure, and electrical performance of PANI were investigated. The results indicated that the intermolecular H‐bonding interaction between molecules of PANI and alcohol is advantageous to the one‐dimensional growth of PANI, and a stirring reaction results in a lager size, a higher doping level, conductivity, degree of crystallinity, and oxidation than a nonstirring reaction. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers.
Acceptance sampling plans for photovoltaic modules with two‐sided specification limits
Authors: Pepelyshev Andrey , Steland Ansgar , Avellan‐Hampe Alejandro 
Published: November 2012

ABSTRACTThe quality control of photovoltaic modules in terms of the output power to satisfy the technical specification is of great importance for producers as well as consumers and also represents a major issue of certification procedures. Previous work focused on one‐sided specification limits to reject underperforming samples (lots) of photovoltaic modules or solar cells. In the present paper, we generalize the classic acceptance sampling methodology and derive sampling plans on the basis of two‐sided specification limits. Those sampling plans can be constructed for arbitrary output power distributions by making use of flash data tables. For the out‐of‐spec setting, the sampling plans are solutions of rather involved nonlinear equations. Explicit formulas, which resemble known sampling plans, can only be obtained under symmetry assumptions. Further, the solution depends on the ratio of overperforming modules to underperforming modules. We investigate by numerical studies to which extent the required sample size depends on that ratio and the shape of the underlying output power distribution. The application to real examples indicates that in practice, the new approach often results in substantially smaller control samples than classic approaches. Copyright © 2012 John Wiley & Sons, Ltd.
Modeling the interface between crystalline silicon and silicon oxide polymorphs
Authors: Kovačević Goran , Pivac Branko 
Published: November 2012

AbstractStructures of interfaces between crystalline silicon and several polymorphes of crystalline silicon oxides were modeled by molecular dynamics (MD) with Reax force field. MD and annealing procedures were conducted in order to create the most plausible interface structure. As the measure of stability of the interface, the energies of selected subsystems, were calculated. The interface between silicon and β‐cristobalite turned out to have an amorphous arrangement of atoms. In all other interfaces, the crystalline order is preserved with defects in form of dislocated oxygen atoms. The interfaces between silicon and tridymite are the most ordered and energetically the most stable, but with the highest strain in the silicon layer.
Stress effect on the orientation and the arrangement of H‐platelets
Authors: Vallet Maxime , Reboh Shay , Beaufort Marie‐France , Grilhé Jean , Barbot Jean François 
Published: November 2012

AbstractThe effect of stress on the formation energy of H‐platelets was studied through a 3D model based on elastic interaction by modelling the platelets as dislocation loops. A difference of self‐formation energy between {111} and {100} platelets was estimated by comparing the calculations with experimental results. When a local source of stress is added to the implantation‐induced stress, different types of platelets could form according to the symmetry of the local stress field. Besides, their arrangement at a nanometre scale makes specific architecture depending on the crystallographic orientation of the surface, 〈001〉‐, 〈011〉‐, or 〈111〉‐orientation. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Cracks and dislocations at Vickers, Berkovich and cube corner indentations in (0001) GaN single crystals
Authors: Ratschinski I. , Leipner H. S. , Heyroth F. , Mook W. , Michler J. , Fränzel W. , Leibiger G. , Habel F. 
Published: November 2012

Abstract(0001) GaN single crystals having a thickness of 3.4 mm and a density of in‐grown dislocations of 3.5 x 106 cm‐2 have been deformed at room temperature using a cube corner, a Berkovich and a Vickers indenter, respectively. Cube corner indentations were performed in a scanning electron microscope in order to observe the deformation in situ. Subsequently, cracks and dislocations at the indentations were investigated by means of optical microscopy, scanning electron microscopy in secondary electron contrast and cathodoluminescence imaging. The arrangement of dislocations is determined by the symmetry of the indented surface. In contrast, the formation of cracks depends on both the shape and the orientation of the indenter. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Dislocation luminescence in highly doped degenerated germanium at room temperature
Authors: Arguirov Tzanimir , Vyvenko Oleg , Oehme Michael , Schulze Jörg , Kittler Martin 
Published: November 2012

AbstractDislocation related electroluminescence was detected in germanium p‐i‐n diodes grown on silicon using a virtual substrate. It appears at room temperature and above a certain threshold of the excitation current. The spectral feature characterizing dislocation related radiation consists of three peaks at around 0.45 eV. The appearance of the dislocation related peaks in the spectrum goes along with a change in the growth rate of the direct band‐to‐band luminescence upon increasing of the current through the structure. The observation is consistent with an injection of minority carriers in the p+ and n+ regions of the diode. As the p+ region contains the misfit dislocation rich virtual substrate it becomes a source of dislocation luminescence. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A magnetoelectric laminate based passive micro‐displacement sensor
Authors: Wu Zheng , Zhang Jun , Ma Ke , Cao Yi , Jia Yanmin , Luo Haosu , Zhang Yihe 
Published: November 2012

AbstractA passive micro‐displacement sensor (for ∼μm displacement) was fabricated based on a magnetoelectric laminate, in which the displacement change can result in a change of the magnetic flux around the magnetoelectric sensor. The displacement measurement was realized by measuring the magnetoelectric output voltage. The displacement detecting coefficient was ∼2.5 mV/μm at a frequency of ∼1 kHz. This passive displacement sensor possesses the advantages of low cost, high resolution, low energy consumption and good linearity and has potential for application in future displacement detectors.magnified imageSchematic diagram of the suggested micro‐displacement sensor based on magnetostrictive/piezoelectric magnetoelectric laminate.(© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Surgical Outcomes of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus: A Korean Multicenter Study
Authors: Moon Deok‐Bog , Hwang Shin , Wang Hee‐Jung , Yun Sung‐Su , Kim Kyung Sik , Lee Young‐Joo , Kim Ki‐Hun , Park Yong‐Keun , Xu Weiguang , Kim Bong‐Wan , Lee Dong Shik , Lee Dong‐Hyun , Kim Hong‐Jin , Lim Jin Hong , Choi Jin Sub , Park Yo‐Han , Lee Sung‐Gyu 
Published: November 2012

AbstractBackgroundThe long‐term outcomes after resection for hepatocellular carcinoma (HCC) with macroscopic bile duct tumor thrombus (BDTT) are unclear. This multicenter study was conducted to determine the prognosis of HCC patients with macroscopic BDTT who underwent resection with curative intent.MethodsOf 4,308 patients with HCC from four Korean institutions, this single‐arm retrospective study included 73 patients (1.7 %) who underwent resection for HCC with BDTT.ResultsJaundice was also present in 34 patients (46.6 %). According to Ueda classification, BDTT was type 2 in 34 cases (46.6 %) and type 3 in 39 cases (53.4 %). Biliary decompression was performed in 33 patients (45.2 %), decreasing the median lowest bilirubin level to 1.4 mg/dL before surgery. Systematic hepatectomy was performed in 69 patients (94.5 %), and concurrent bile duct resection was performed in 31 patients (42.5 %). Surgical curability types were R0 (n = 57; 78.1 %), R1 (n = 11; 15.1 %), and R2 (n = 5; 6.8 %). Patient survival rates were 76.5 % at 1 year, 41.4 % at 3 years, 32.0 % at 5 years, and 17.0 % at 10 years. Recurrence rates were 42.9 % at 1 year, 70.6 % at 3 years, 77.3 % at 5 years, and 81.1 % at 10 years. Results of univariate survival analysis showed that maximal tumor size, bile duct resection, and surgical curability were significant risk factors for survival, and surgical curability was a significant risk factor for recurrence. Multivariate analysis did not reveal any independent risk factors.ConclusionsHepatocellular carcinoma patients with BDTT achieved relatively favorable long‐term results after resection; therefore extensive surgery should be recommended when complete resection is anticipated.
Acceptance of Genetic Counseling and Testing in a Hospital‐Based Series of Patients with Gynecological Cancer
Authors: Dekker Nicky , van Dorst Eleonora B. L. , van der Luijt Rob B. , van Gijn Marielle E. , van Tuil Marc , Offerhaus Johan A. , Ausems Margreet G. E. M. 
Published: November 2012

AbstractReferral of patients with endometrial (EC) and/or ovarian cancer (OC) for genetic counseling is based on age at diagnosis and family history. Many patients with hereditary cancers are missed by following this strategy. We determined acceptance and mutation detection rate of offering genetic counseling and testing to unselected EC and OC patients. Therefore, in 2007, EC and OC patients were invited for genetic counseling and testing. Patients were asked for their reasons to accept or decline. Nineteen out of fifty‐two EC patients (36 %) and twenty‐two out of thirty‐five OC patients (63 %) accepted genetic counseling, mainly to receive risk assessment for themselves and relatives. Counseling was declined mainly because patients did not want more tests or had no relatives for whom it was relevant. Eighteen out of nineteen EC patients (95 %) and twenty out of twenty‐two OC patients (91 %) underwent genetic testing. One EC patient carried an MSH6 mutation (mutation detection rate: 6 %). BRCA1/2 mutations were found in two out of twenty OC patients (10 %). Eleven patients (29 %) received surveillance recommendations for themselves and their relatives. Finally, family history recorded by the gynecologist was compared to that taken by the clinical geneticist. Gynecologists reported family history in ten out of forty‐one participants (24 %). In conclusion, genetic counseling and testing are acceptable to patients with OC and/or EC. The 10 % BRCA1/2 mutation detection rate and underreporting of family history by gynecologists warrant referral for genetic counseling for all OC patients, followed by BRCA1/2 testing if indicated. We recommend that microsatellite instability and immunohistochemical analysis be performed in all EC patients, followed by genetic counseling if appropriate. These strategies will lead to better cancer prevention in gynecological cancer patients and their relatives.
The Effect of Time after Shear Injury on the Subsynovial Connective Tissue and Median Nerve within the Rabbit Carpal Tunnel
Authors: Vanhees Matthias , Chikenji Takako , Thoreson Andrew R. , Zhao Chunfeng , Schmelzer James D. , Low Philip A. , An Kai-Nan , Amadio Peter C. 
Published: November 2012

Background The most prominent nonneurological finding in the common compression neuropathy carpal tunnel syndrome (CTS) is fibrosis of the subsynovial connective tissue (SSCT). Recently, a rabbit model of CTS has been developed, based on the hypothesis that SSCT injury and subsequent fibrosis cause nerve compression. The purpose of this study was to evaluate the effects in this model at earlier and later time points than have heretofore been reported. Methods Sixty rabbits were operated on and observed at two different time periods: 6 and 24 weeks. Nerve electrophysiology (EP), SSCT histology, and SSCT mechanical properties were assessed. Results There was no significant difference in median motor nerve amplitude or latency at either time point. The total cell density in the SSCT was significantly higher at 6 and 24 weeks compared to controls. The mean size of the collagen fibrils in the SSCT was higher 6 and 24 weeks after surgery compared to controls. Both the ultimate load and the total energy absorption of the SSCT were significantly higher at 6 and 24 weeks compared to controls. Conclusions In this model, there were signs of SSCT fibrosis and histology changes at 6 weeks, which persist after 24 weeks. Thus, this model leads to sustained SSCT fibrosis, which is one characteristic of human CTS. However, no significant EP changes were found at these two time points, which is in contrast to the findings reported previously for this model at 12 weeks. The significance of the differences in EP findings will be the subject of future studies.