bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced expression of a 35 kDa fragment of inter-alpha-trypsin inhibitor H4 in sera of healthy pregnant women and patients with hydatidiform mole
Authors: Mohamed Emida , Jayapalan Jaime Jacqueline , Abdul-Rahman Puteri Shafinaz , Omar Siti Zawiah , Hashim Onn Haji 
Published: May 2013

Abstract

Background
Accumulated data from previous studies appear to suggest a link between the overexpression of a 35 kDa fragment of serum inter-alpha-trypsin inhibitor H4 (ITIH4) with cancers that are associated with up-regulated levels of oestrogens. The truncated fragment was postulated to be a product of oestrogen-induced action of kallikrein on native ITIH4. The present lectin-based proteomic analyses were performed to assess the specificity of the 35 kDa fragment of ITIH4 as a potential cancer biomarker and determine whether it was also overexpressed in the sera of cancer-negative pregnant women who are known to have high levels of plasma oestrogens.

Results
Our results demonstrated that the 35 kDa fragment of ITIH4 was overexpressed in healthy pregnant women and patients with hydatidiform mole, relative to the controls. The serum oestradiol levels of both groups of pregnant subjects were also confirmed to be higher than those of the control women who were not pregnant.

Conclusions
Overexpression of the 35 kDa fragment of ITIH4 was not restrictive to patients with cancers but also occurred in women who were pregnant and those diagnosed with hydatidiform mole. Our data implicate the limitation of the 35 kDa ITIH4 fragment as a cancer biomarker and its correlation with serum oestrogen levels.
Avoidance and tolerance of freezing in ectothermic vertebrates
Authors: Costanzo Jon P. , Lee Richard E. 
Published: May 2013

Summary
Ectothermic vertebrates have colonized regions that are seasonally or perpetually cold, and some species, particularly terrestrial hibernators, must cope with temperatures that fall substantially below 0°C. Survival of such excursions depends on either freeze avoidance through supercooling or freeze tolerance. Supercooling, a metastable state in which body fluids remain liquid below the equilibrium freezing/melting point, is promoted by physiological responses that protect against chilling injury and by anatomical and behavioral traits that limit risk of inoculative freezing by environmental ice and ice-nucleating agents. Freeze tolerance evolved from responses to fundamental stresses to permit survival of the freezing of a substantial amount of body water under thermal and temporal conditions of ecological relevance. Survival of freezing is promoted by a complex suite of molecular, biochemical and physiological responses that limit cell death from excessive shrinkage, damage to macromolecules and membranes, metabolic perturbation and oxidative stress. Although freeze avoidance and freeze tolerance generally are mutually exclusive strategies, a few species can switch between them, the mode used in a particular instance of chilling depending on prevailing physiological and environmental conditions.
Successful Treatment of Pulmonary Blastomycosis with Continuously Infused Amphotericin B Deoxycholate After Failure with Liposomal Amphotericin B
Authors: Ariano Robert E , Mitchelmore Bradley R , Lagacé-Wiens Philippe RS , Zelenitsky Sheryl A 
Published: May 2013

OBJECTIVE: To describe a case of successful treatment of severe pulmonary blasto mycosis with amphotericin B deoxycholate after failure of liposomal amphotericin B. CASE SUMMARY: A 35-year-old male was exposed to damp decomposing wood while cleaning his basement. He subsequently developed a cough, malaise, fever, nausea, vomiting, and diarrhea. He was admitted to the hospital and intubated for worsening pulmonary symptoms. Microscopic examination of his sputum indicated Blastomyces dermatitidis. Liposomal amphotericin B was administered for 6 days, but the patient's temperature reached 39.6 °C and his white blood cell (WBC) count reached 52,300/ μL. Extensive consolidation of both lungs fields was observed on chest X-ray. Because of progressive clinical deterioration, the treatment was switched to amphotericin B deoxycholate by continuous infusion. That change resulted in clinical improvement, with abrupt reductions (within 48 hours) in temperature and the WBC count. By day 14 of therapy (day 8 of amphotericin B deoxycholate), the chest X-ray showed improvement in diffuse airspace filling. After 16 days of amphotericin B treatment, intravenous followed by oral voriconazole was administered for 3 months. Eight months later the patient's strength had improved significantly, but he still had occasional episodes of shortness of breath. DISCUSSION: The management of blastomycosis is challenging because of the lack of clinically supporting data. The gold standard for severe pulmonary blastomycosis had been amphotericin B deoxycholate; however, improved safety data with liposomal amphotericin B for other fungal infections has suggested this as an effective alternative. This report describes a patient with severe pulmonary blastomycosis failing 6 days of liposomal amphotericin B, yet he tolerated and clinically responded to continuous infusion of amphotericin B deoxycholate. Based on this case report and a simulated pharmacokinetic/pharmacodynamic analysis, continuous infusion of amphotericin B deoxycholate may be a reasonable option for enhanced efficacy and minimal toxicity in patients with blastomycosis. CONCLUSIONS: Ours is the first case report to use continuous infusion of amphotericin B deoxycholate for the management of pulmonary blastomycosis. These results suggest that liposomal amphotericin B may not be adequate in some patients for the management of B. dermatitidis pulmonary infections.
Subtherapeutic Linezolid Concentrations in a Patient with Morbid Obesity and Methicillin-Resistant Staphylococcus aureus Pneumonia: Case Report and Review of the Literature
Authors: Muzevich Katie M , Lee Kimberly B 
Published: May 2013

OBJECTIVE: To report a case of subtherapeutic linezolid concentrations in a patient with morbid obesity. CASE SUMMARY: A 34-year-old male with morbid obesity (265 kg, body mass index 82 kg/m2) was admitted for severe sepsis due to respiratory failure requiring emergent intubation and treatment of community-acquired pneumonia. Admission tracheal aspirate culture revealed methicillin-resistant Staphylococcus aureus (MRSA) for which vancomycin was prescribed. Therapy subsequently was changed to linezolid, because the patient's clinical status worsened, with significant hypoxia (partial pressure of arterial oxygen/fraction of inspired oxygen [PaO2/FiO2] ratio 145), increasing leukocytosis (white blood cell count from 10,800/ μL on admission to 15,400/ μL on hospital day 6), and persistent fever (38.3 °C). After 48 hours of linezolid monotherapy, the patient remained febrile with continued leukocytosis, worsening hypoxemia, and a persistently positive MRSA culture from a repeat endotracheal aspirate. Linezolid serum concentrations were obtained and vancomycin was reinstituted, after which the patient began to improve (afebrile, improving PaO2/FiO2 ratio, decreasing leukocytosis). On hospital day 12, the patient removed his endotracheal tube, and a sputum sample was obtained for culture. The patient's clinical status subsequently declined, prompting addition of cefepime to his antibiotic regimen. This sputum culture revealed not only MRSA, but also quinolone-resistant Escherichia coli. After completing treatment for both organisms the patient was discharged home. DISCUSSION: Limited data on linezolid dosing in the morbidly obese population show lower serum drug concentrations than those in nonobese patients, but no clinical failure has been reported when treating MRSA skin and soft tissue infections or MRSA tracheitis. In our patient, low steady-state linezolid serum concentrations (peak 4.13 μg/mL [reference 15-27] and trough 1.27 μg/mL [reference 2-9]) were thought to contribute to his poor clinical response. CONCLUSIONS: To our knowledge, this is the first report of subtherapeutic linezolid concentrations correlated with decreased clinical effectiveness when during treatment of MRSA pneumonia in a patient with morbid obesity.
Dabigatran: Is There a Role for Coagulation Assays in Guiding Therapy?
Authors: Brunetti Luigi , Bandali Farooq 
Published: May 2013

objective: To determine the usefulness of coagulation assay monitoring for dabigatran etexilate in certain high-risk clinical situations. DATA SOURCES: Literature retrieval was accessed through MEDLINE (1948-February 2013), Web of Science (1980-February 2013), International Pharmaceutical Abstracts (1977-February 2013), and Google Scholar using the terms dabigatran, dabigatran etexilate, BIBR 1048, BIBR 953, direct thrombin inhibitor, therapeutic monitoring, and atrial fibrillation. In addition, abstracts presented at the 2011-2012 American Society of Hematology, American College of Cardiology, International Society of Thrombosis and Haemostasis, and European Society of Cardiology annual meetings were reviewed. A search of Clinicaltrials.gov was performed to identify relevant ongoing or completed research. STUDY SELECTION AND DATA EXTRACTION: All English-language articles identified from the data sources were evaluated for inclusion. Priority was placed on all data derived from controlled clinical studies. DATA SYNTHESIS: Of the 6 published Phase 3 studies, only the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial evaluated the safety and efficacy of dabigatran for the prevention of stroke in patients with nonvalvular atrial fibrillation. Post hoc analyses of the RE-LY trial have provided additional information in special situations. Several published reports highlight the potential for complications with dabigatran, the importance of determining the most optimal candidates, and the need for therapeutic monitoring. Activated partial thromboplastin time and thrombin time are effective qualitative assays for dabigatran. Ecarin clotting time and the dilute thrombin time (ie, Hemoclot direct thrombin inhibitor) assays are suitable for quantitative measurement. CONCLUSIONS: The correlation between coagulation-based assays and clinical outcomes among dabigatran-treated patients has not been definitively established. However, coagulation-based assays may be useful in the management of several clinical scenarios.
Mental Health Treatment Associated with Community-Based Depression Screening: Considerations for Planning Multidisciplinary Collaborative Care
Authors: Winchester Bruce R , Watkins Sarah C , Brahm Nancy C , Harrison Donald L , Miller Michael J 
Published: May 2013

BACKGROUND: Depression places a large economic burden on the US health care system. Routine screening has been recognized as a fundamental step in the effective treatment of depression, but should be undertaken only when support systems are available to ensure proper diagnosis, treatment, and follow-up. OBJECTIVE: To estimate differences in prescribing new antidepressants and referral to stress management, psychotherapy, and other mental health (OMH) counseling at physician visits when documented depression screening was and was not performed. METHODS: Cross-sectional physician visit data for adults from the 2005-2007 National Ambulatory Medical Care Survey were used. The final analytical sample included 55,143 visits, representing a national population estimate of 1,741,080,686 physician visits. Four dependent variables were considered: (1) order for new antidepressant(s), and referral to (2) stress management, (3) psychotherapy, or (4) OMH counseling. Bivariable and multivariable associations between depression screening and each measure of depression follow-up care were evaluated using the design-based F statistic and multivariable logistic regression models. RESULTS: New antidepressant prescribing increased significantly (2.12% of visits without depression screening vs 10.61% with depression screening resulted in a new prescription of an antidepressant). Referral to stress management was the behavioral treatment with the greatest absolute change (3.31% of visits without depression screening vs 33.10% of visits with depression screening resulted in a referral to stress management). After controlling for background sociodemographic characteristics, the adjusted odds ratio of a new antidepressant order remained significantly higher at visits involving depression screening (AOR 5.36; 99.9% CI 2.92-9.82), as did referrals for all behavioral health care services (ie, stress management, psychotherapy, and OMH counseling). CONCLUSIONS: At the national level, depression screening was associated with increased new antidepressant prescribing and referral for behavioral health care. It is critical for policy planners to recognize changes in follow-up depression care when implementing screening programs to ensure adequate capacity. Pharmacists are poised to assume a role in collaborative depression care, particularly with antidepressant medication therapy management.
REVIEWS
Authors: Pueyo Miquel , Cerdán Josetxo , Oroz Elena , Carrera Mar , Corcuera Raúl Martínez , Binimelis Mar , López Jaume , Zecchi Barbara 
Published: May 2013

AICNÀLUBMA. REFLEXIONS SOBRE LA SOCIETAT I ELS MITJANS. PROPOSTES PER A LA NOVA TELEVISIÓ, JOAQUIM M. PUYAL (2011) Barcelona: Columna Edicions S.A., 348 pp., ISBN: 978-84-664-1372-5, p/bk, €23.50.
LA TELEVISIÓN DURANTE LA TRANSICIÓN ESPAÑOLA,
MANUEL PALACIO (2012) Madrid: Cátedra, 453 pp., ISBN: 978-84-376-3068-7, h/bk, €22.50
WHITE GYPSIES. RACE AND STARDOM IN SPANISH MUSICALS, EVA WOODS PEIRÓ (2012) Minneapolis and London: University of Minnesota Press, 337pp.,ISBN: 978-0-8166-4584-8, h/bk, $75; ISBN:
978-0-8166-4585-5,p/bk, $25
CORRESPONSALS DE LES MIGRACIONS, JEAN-PAUL MARTHOZ (2012) Adapted by Carles Solá and Marta Muixí. Barcelona: Pol·len Edicions, 232 pp., ISBN: 978-84-86469-35-1, p/bk, €19
MINORÍAS EN RED. MEDIOS Y MIGRACIÓN EN
EUROPA, CILIA WILLEM (ED.) 2011 Col·lecció Transmedia XXI: Laboratori de Mitjans Interactius, Universitat de Barcelona, 110 pp., ISBN-10: 1466449810, p/bk, $10
TRANSNACIONALIZACIÓN DE LA FICCIÓN TELEVISIVA EN LOS PAÍSES IBEROAMERICANOS: ANUARIO
OBITEL 2012, GUILLERMO OROZCO GÓMEZ AND MARIA IMMACOLATA VASSALO DE LOPES (EDS) 2012 Porto Alegre: Sulina- Globo Comunicação, 592 pp., ISBN: 978-85-205-0664-6, Open Access, http://obitel.net/
LA MEDIATIZACIÓN DEL CONFLICTO POLÍTICO. DISCURSOS Y NARRATIVAS
EN EL CONTEXTO ESPAÑOL, ENRIC CASTELLÓ (ED) 2012 Barcelona: Laertes, 247 pp., ISBN: 978-84-7584-879-2, p/bk, €16
IMÁGENES DEL EROS: GÉNERO, SEXUALIDAD, ESTÉTICA Y CULTURA AUDIOVISUAL, FRANCISCO A. ZURIAN (ED) 2012 Madrid: Ocho y Medio, 311 pp., ISBN:
978-84-96582-78-1, p/bk, €12
‘ street water’: A community project to discover the underground network that connects the city with its rivers
Authors: Vianna Rachel De Sousa , Aragão Gaby De 
Published: May 2013

This is the story of ‘Street Water Project’, which took place in the neighbourhood of Santo Antônio, in Belo Horizonte, Brazil, between November 2010 and July 2011. The activities consisted of art and environment workshops in schools and poetic interventions in public
spaces designed to raise awareness of the population regarding the water sources that supply the city.
Esta é a história do projeto Água da Rua, realizado no Bairro Santo Antônio, na cidade de Belo Horizonte, Brasil, entre novembro de 2010 e julho de 2011. Tendo
como objetivo conscientizar a população sobre os recursos hídricos que abastecem a cidade, o projeto promoveu oficinas de arte e de educação ambiental em escolas e organizou intervenções poéticas em espaços públicos.
Molecular Characterization of Two Sensory Neuron Membrane Proteins fromChilo suppressalis(Lepidoptera: Pyralidae)
Authors: Liu Su , Qiao Fei , Liang Qing-Mei , Huang Yuan-Jie , Zhou Wen-Wu , Gong Zhong-Jun , Cheng Jiaan , Zhu Zeng-Rong 
Published: May 2013

AbstractSensory neuron membrane proteins (SNMPs) play an especially important role in insect pheromone communication. However, the SNMPs for the Asiatic rice borer, Chilo suppressalis (Walker) (Lepidoptera: Pyralidae), a notorious rice pest, remain uncharacterized. Here we report the cloning and characterization of two novel SNMPs from the C. suppressalis, CsupSNMP1 and CsupSNMP2. The CsupSNMP1 and CsupSNMP2 cDNAs contained open reading frames (ORFs) of 1,572 and 1,569 bp, encoding proteins of 523 and 522 amino acid residues, respectively. The amino acid identity between the two deduced CsupSNMPs was low (30% identity), but they shared a high degree of similarity to previously characterized SNMP1s or SNMP2s from other moth species, which is consistent with phylogenetic analysis in which CsupSNMP1 and CsupSNMP2 are clustered into two distinct groups based on their amino acid sequences. The expression patterns of CsupSNMPs in various adult tissues and in different developmental stages were determined by real-time quantitative polymerase chain reaction. The results showed that both CsupSNMP1 and CsupSNMP2 were abundantly expressed in the male and female antennae, reaching their maximum in the adult stage, suggesting the two genes are involved in the process of olfaction. Low levels of CsupSNMP2 also were expressed in nonolfactory tissues such as legs and wings, implying possible gustatory roles of the protein in the moth.
Responses of Diaphorina citri (Hemiptera: Psyllidae) to Conspecific Vibrational Signals and Synthetic Mimics
Authors: Rohde B , Paris T M , Heatherington E M , Hall D G , Mankin R W 
Published: May 2013

Abstract
Mate-seeking in Diaphorina citri Kuwayama, a vector of the economically damaging huanglongbing citrus disease, typically includes male—female duetting behaviors. First, the male calls by beating his wings at ≈170–250 Hz, producing vibrations that are transmitted along the host tree branches to the female. If receptive, she immediately replies, helping to direct the searching male toward her. The duetting and searching continues until the male locates the female. Males and females are similar in size and produce wingbeat vibrations with similar temporal and spectral patterns. A study of male and female responses to playbacks of recorded and synthetic mimics of different vibrational signals on citrus plants was conducted to better understand the range of signals to which D. citri respond and potentially to co-opt or disrupt their vibrational communication. In general, both sexes responded well to a variety of 0.3–0.5-s signals that included multiple harmonics of ≈200-Hz wingbeatfrequency chirps up to ≈1,400 Hz (where a chirp is a sine wave tone that sweeps across a narrow range of frequencies). There were only minor differences in female responses to signals containing different relative amplitudes of such chirps, and males readily located sources that played these multipleharmonic signals. The results are discussed in relation to mating-signal selectivity and the potential for developing automated methods to trap male D. citri by using vibrational signals.
On Colimits and Elementary Embeddings
Authors: Bagaria Joan , Brooke-Taylor Andrew 
Published: May 2013

AbstractWe give a sharper version of a theorem of Rosický, Trnková and Adámek [13], and a new proof of a theorem of Rosický [12], both about colimits in categories of structures. Unlike the original proofs, which use category-theoretic methods, we use set-theoretic arguments involving elementary embeddings given by large cardinals such as α-strongly compact and C(n)-extendible cardinals.
Probabilistic Algorithmic Randomness
Authors: Buss Sam , Minnes Mia 
Published: May 2013

AbstractWe introduce martingales defined by probabilistic strategies, in which randomness is used to decide whether to bet. We show that different criteria for the success of computable probabilistic strategies can be used to characterize ML-randomness, computable randomness, and partial computable randomness. Our characterization of ML-randomness partially addresses a critique of Schnorr by formulating ML randomness in terms of a computable process rather than a computably enumerable function.
A quasi-order on continuous functions
Authors: Carroy Raphaël 
Published: May 2013

AbstractWe define a quasi-order on Borel functions from a zero-dimensional Polish space into another that both refines the order induced by the Baire hierarchy of functions and generalises the embeddability order on Borel sets. We study the properties of this quasi-order on continuous functions, and we prove that the closed subsets of a zero-dimensional Polish space are well-quasi-ordered by bi-continuous embeddability.
On the definability of radicals in supersimple groups
Authors: Milliet Cédric 
Published: May 2013

AbstractIf G is a group with a supersimple theory having a finite SU-rank, then the subgroup of G generated by all of its normal nilpotent subgroups is definable and nilpotent. This answers a question asked by Elwes, Jaligot, Macpherson and Ryten. If H is any group with a supersimple theory, then the subgroup of H generated by all of its normal soluble subgroups is definable and soluble.
Surgery for Retinal Detachment in Patients With Giant Retinal Tear: Etiologies, Management Strategies, and Outcomes
Authors: Gonzalez Marco A. , Flynn Harry W. , Smiddy William E. , Albini Thomas A. , Tenzel Paul 
Published: May 2013

BACKGROUND AND OBJECTIVE:
To evaluate etiologies, management, and outcomes for patients with giant retinal tears undergoing initial surgery at a single institution.

PATIENTS AND METHODS:
Noncomparative, retrospective, consecutive case series at a university referral center including 79 eyes of 77 patients.

RESULTS:
Blunt trauma constituted 22% of cases. All patients underwent pars plana vitrectomy with gas or silicone oil tamponade. Eighty-five percent (67 eyes) underwent an encircling scleral buckle. Perfluorocarbon liquids were used in 71% (61 eyes). Eighteen percent (14 eyes) underwent re-operation for recurrent retinal detachment. Ninety-two percent (73 eyes) achieved anatomic success with one or more surgical procedures. Visual acuity at last follow-up was at least 20/400 in 84.9% of patients (28 of 33) with 3 clock hours compared to 65.2% (30 of 46) with tears greater than 3 clock hours.

CONCLUSION:
Patients with giant retinal tear undergoing surgery achieved high rates of anatomic success, but re-operations were frequent. Better visual outcomes were associated with smaller circumferential dimensions in the giant retinal tears.

[
Ophthalmic Surg Lasers Imaging Retina.
2013;44:232–237.]
The Role of ILM Peeling in Vitreous Surgery for Proliferative Diabetic Retinopathy Complications
Authors: Michalewska Zofia , Bednarski Maciej , Michalewski Janusz , Jerzy Nawrocki 
Published: May 2013

BACKGROUND AND OBJECTIVE:
To evaluate the influence of pars plana vitrectomy (PPV) with or without internal limiting membrane (ILM) peeling on spectral-domain optical coherence tomography (SD-OCT) in vitreous hemorrhage and tractional retinal detachment as a complication of diabetic retinopathy.

PATIENTS AND METHODS:
Retrospective study of PPV in patients with diabetic retinopathy complications. Group A (53 patients) had PPV with ILM peeling, and group B (59 patients) had PPV without ILM peeling. SD-OCT imaging and fluorescein angiography were performed postoperatively.

RESULTS:
Preoperative visual acuity was 0.04 and final postoperative visual acuity was 0.27 in both groups (23.4 months in group A, 60 months in group B). Postoperative central retinal thickness was 193 μm (group A) and 258.6 μm (group B). Epiretinal membranes were observed less frequently in group A than in group B (24% vs 49%). Repeated surgeries were performed in 38 cases in group A and in 51 cases in group B.

CONCLUSION:
Fewer cases of epiretinal membranes and macular edema are observed postoperatively with ILM peeling. Visual acuity is similar in both groups, but additional surgeries are fewer with ILM peeling.

[
Ophthalmic Surg Lasers Imaging Retina.
2013;44:238–242.]