bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trastuzumab Deruxtecan in Human Epidermal Growth Factor Receptor 2–Expressing Biliary Tract Cancer (HERB; NCCH1805): A Multicenter, Single-Arm, Phase II Trial
Authors: Ohba Akihiro , Morizane Chigusa , Kawamoto Yasuyuki , Komatsu Yoshito , Ueno Makoto , Kobayashi Satoshi , Ikeda Masafumi , Sasaki Mitsuhito , Furuse Junji , Okano Naohiro , Hiraoka Nobuyoshi , Yoshida Hiroshi , Kuchiba Aya , Sadachi Ryo , Nakamura Kenichi , Matsui Naoko , Nakamura Yoshiaki , Okamoto Wataru , Yoshino Takayuki , Okusaka Takuji 
Published: August 2024

PURPOSE Treatment options for patients with unresectable or recurrent biliary tract cancer (BTC) who progress on a gemcitabine-containing regimen are limited. In addition, the significance of anti–human epidermal growth factor receptor 2 (HER2) therapy in HER2-expressing BTC has not been sufficiently investigated. METHODS In this phase II trial, participants from five institutions in Japan were enrolled. Eligible patients had pathologically confirmed unresectable or recurrent BTC with centrally confirmed HER2-positive (immunohistochemistry [IHC]3+ or IHC2+ and in situ hybridization [ISH]+) or HER2-low (IHC2+ and ISH–, IHC1+, and IHC0 and ISH+) and were refractory or intolerant to a gemcitabine-containing regimen. The patients received 5.4 mg/kg trastuzumab deruxtecan (T-DXd) once every 3 weeks until disease progression or unacceptable toxicity. The primary end point was the confirmed objective response rate (ORR) in HER2-positive BTC by an independent central review (threshold ORR, 15%; expected ORR, 40%). RESULTS A total of 32 patients were enrolled and treated. Among these patients, 22 with HER2-positive disease comprised the primary efficacy population and had a confirmed ORR of 36.4% (90% CI, 19.6 to 56.1; P = .01), meeting the primary end point. Eight with HER2-low disease comprised the exploratory population and had a confirmed ORR of 12.5%. The most common ≥grade 3 treatment-related adverse events were anemia (53.1%) and neutropenia (31.3%). Eight patients (25.0%) had interstitial lung disease (ILD), including two grade 5 events. CONCLUSION T-DXd showed promising activity in patients with HER2-positive BTC and a signal of efficacy in patients with HER2-low BTC. Although the safety profile was generally manageable, ILD requires careful monitoring and early intervention.
Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial
Authors: Ludmir Ethan B. , Sherry Alexander D. , Fellman Bryan M. , Liu Suyu , Bathala Tharakeswara , Haymaker Cara , Medina-Rosales Marina N. , Reuben Alexandre , Holliday Emma B. , Smith Grace L. , Noticewala Sonal S. , Nicholas Sarah , Price Tracy R. , Martin-Paulpeter Rachael M. , Perles Luis A. , Lee Sunyoung S. , Lee Michael S. , Smaglo Brandon G. , Huey Ryan W. , Willis Jason , Zhao Dan , Cohen Lorenzo , Taniguchi Cullen M. , Koay Eugene J. , Katz Matthew H.G. , Wolff Robert A. , Das Prajnan , Pant Shubham , Koong Albert C. , Tang Chad 
Published: August 2024

PURPOSE
The EXTEND trial tested the hypothesis that adding comprehensive metastasis-directed therapy (MDT) to chemotherapy would improve progression-free survival (PFS) over chemotherapy alone among patients with oligometastatic pancreatic ductal adenocarcinoma (PDAC).

METHODS

EXTEND (ClinicalTrials.gov identifier:
NCT03599765
) is a multicenter, phase II basket trial randomly assigning patients with ≤five metastases 1:1 to MDT plus systemic therapy versus systemic therapy. Disease progression was defined by radiologic criteria (RECIST v1.1), clinical progression, or death. The primary end point was PFS in the per-protocol population, evaluated after all patients achieved at least 6 months of follow-up. Exploratory end points included systemic immune response measures.

RESULTS

Between March 19, 2019, and February 13, 2023, 41 patients were randomly assigned and 40 were eligible for the primary analysis of PFS (19 patients in the MDT arm; 21 patients in the control arm). At a median follow-up time of 17 months, the median PFS time was 10.3 months (95% CI, 4.6 to 14.0) in the MDT arm versus 2.5 months (95% CI, 1.7 to 5.1) in the control arm. PFS was significantly improved by the addition of MDT to systemic therapy (
P
= .030 for stratified log-rank test) with a hazard ratio of 0.43 (95% CI, 0.20 to 0.94). No grade ≥3 or greater adverse events related to MDT were observed. Systemic immune activation events were associated with MDT and correlated with improved PFS.

CONCLUSION
This study supports the addition of MDT to systemic therapy for patients with oligometastatic PDAC. Induction of systemic immunity is a possible mechanism of benefit. These results warrant confirmatory trials to refine treatment strategy and provide external validation.
SIADH as a Rare Complication of Foramen Magnum Stenosis in an Infant With Achondroplasia
Authors: Cebeci Ayse Nurcan , Hebert Steven , Reutter Heiko , Rompel Oliver , Woelfle Joachim 
Published: August 2024

Abstract
Achondroplasia is the most common skeletal dysplasia and is associated with serious complications such as foramen magnum stenosis (FMS). This case report describes an infant with achondroplasia who presented with a syndrome of inappropriate antidiuretic hormone secretion (SIADH), secondary to significant FMS and myelocompression. A 2-month-old boy with prenatally diagnosed achondroplasia was referred due to disordered breathing and altered consciousness. On admission, apathy, hypotonus, and hypothermia with typical features of achondroplasia were noticed. Laboratory investigations revealed severe hyponatremia and hypochloridaemia with normal glucose and urea levels. The diagnosis of SIADH was made based on low serum osmolality in the presence of high urine osmolality, along with an elevated copeptin level. An emergency computerized tomography showed a high-grade stenosis at the cranio-cervical junction; subsequent magnetic resonance imaging demonstrated myelocompression. The patient underwent decompression surgery the next day; serum osmolality increased after the operation. Spontaneous breathing after extubation was sufficient whereas tetraplegia persisted despite intensive physiotherapy. Clinicians should be aware of SIADH as a presenting sign of FMS in children with achondroplasia. Further discussion is warranted regarding improving parental education and timing of screening recommendations.
Introduction
Authors: McManus Anne-Marie , Reynolds Nancy Y. 
Published: August 2024

Abstract
The Middle East and North Africa (MENA) today is an epicenter for the theorization of absence. Scholars, in efforts to counter the politics that have erased and continue to erase humans and places from the region, frequently assert the microdynamics of resistance, resilience, and memory. The editors of the special section, “Following Absence,” acknowledge the urgent need for narratives of overcoming destruction and for acts of care and repair. However, this introduction articulates a different intellectual labor—one that examines the ways absences linger and perdure across the MENA. Rather than restoring or recuperating modes of presence, the editors ask, in what ways might absence be told and accounted for? How might new plotlines widen the scope of what can be perceived as absence, its work in the world, and the forms of agency and injury it shapes? In dialogue with the environmental humanities, this thematic section approaches human lives in embodied proximities to the nonhuman. It also relinquishes the need for storytelling to begin from a moment when annihilating violence has ceased, as though erasure could be safely contained in the past. Repetitive and accumulating, recursive and anticipatory, absences inhabit the present and future. Acknowledging these branching, seeping plotlines, the editors urge against any unified theory of absence for, or from, the MENA. Absence is defined by negation, fragments, and residues. By refusing its systematization in scholarship, this introduction calls for modes of attention that refuse the logics of power and foreground instead the flourishing of ongoing life. It then previews the special section's themes and articles.
Vanishing Nubia
Authors: Reynolds Nancy Y. 
Published: August 2024

Abstract
As the Nasserist state built a large hydroelectric dam in the south of Egypt in the early 1960s, Egyptian botanists undertook salvage surveys of the area to be flooded behind the dam, known as historic Nubia. Scientists in these surveys searched for a type of palm tree (Medemia argun) well documented in ancient Egyptian tombs but unrecorded “in living condition” since the late eighteenth century. Gathering written and photographic accounts in memoirs, archives, and botanical tracts, this essay charts the documentary traces of the search for Medemia argun and the affective responses that surface along the margins of texts to show how debate over the potential absence or extinction of a “flagship” endogenous plant coincided with two important shifts in botanical knowledge production: transitions in botany as a discipline that employed new research methodologies and located Egypt “geobotanically” as the temporal and spatial origin for world flora; and transitions in botany as an arena of scientific expertise during postcolonial nationalism's reordering of the Egyptian academy. Building on extinction and destroyed landscape studies, this article explores ecological lexicons of absence and practices of “following” in botany.
“A Nonexistent Incapacity”
Authors: Gruskin Rebecca 
Published: August 2024

Abstract
In the 1920s and 1930s, the French colonial phosphate mining company in Gafsa, Tunisia, used X-ray images to decide which of its workers’ injuries were fake and which were real. Through an analysis of X-ray photography in Gafsa, this article argues that a capacious history of capitalism—one connecting wage labor exploitation with other human and nonhuman work—requires methods that do not prioritize what is visible. Rather than asking what X-ray images show diagnostically, this article charts how the creation of visibility and invisibility was a political act, a tactic of capital accumulation, and an arena of contestation. Company administrators and doctors used X-rays to draw biomedical and temporal boundaries around chronic injuries, making them “nonexistent”—and thus noncompensable—despite workers’ claims. This colonial-racial project both reified and remade the company's semantic categories for defining what an injury was. The company mobilized the material and epistemological properties of X-ray light on a photographic negative to erase chronic injury within dark or blurred spaces. The resulting category, a “nonexistent incapacity,” acknowledged both the presence of injury and its disappearance, constructing visibility and invisibility within capitalist relations of production and exploitation. Read this way, Gafsa's X-ray images ultimately outline a political economy of (in)visibility.
Jewish Spaces in Egypt as Sites of Memory
Authors: Hussein Mostafa 
Published: August 2024

Abstract
This article explores Jewish spaces in Cairo as repositories of memory and their role in shaping a collective understanding of the Jewish past among non-Jewish Egyptians. By examining these sites through the perspectives of engaged observers, it uncovers their multifaceted reflections of Jewish life and culture. Interactions with these sites reveal the intricate interplay of internal and external factors, such as the dynamics between Jews and Muslims, the reverberations of the Arab-Israeli conflict, and societal responses to Jewish culture. These sites evoke a sense of patriotism among Egyptian Jews and their fellow citizens, marked by the fusion of Arabic, Hebrew, Judaism, and Islam. Understanding this perspective necessitates considering the roles of various stakeholders, including the remaining Jewish community, state institutions, conservationists, and scholarly professionals. It also requires an examination of ongoing societal debates and official decisions regarding the preservation or demolition of Jewish sites. Diverse viewpoints emerge from these discussions, reflecting issues like anti-Semitism, anti-Israel sentiments, distrust of the Egyptian state, and prioritizing the preservation of inhabited spaces over abandoned ones. By shedding light on these contradictions within Egyptian public discourse, this article underscores the significance of acknowledging and celebrating Egyptian Jewish heritage, which continues to shape society today.
Akt is a mediator of artery specification during zebrafish development
Authors: Zhou Wenping , Ghersi Joey J. , Ristori Emma , Semanchik Nicole , Prendergast Andrew , Zhang Rong , Carneiro Paola , Baldissera Gabriel , Sessa William C. , Nicoli Stefania 
Published: August 2024

ABSTRACT
The dorsal aorta (DA) is the first major blood vessel to develop in the embryonic cardiovascular system. Its formation is governed by a coordinated process involving the migration, specification, and arrangement of angioblasts into arterial and venous lineages, a process conserved across species. Although vascular endothelial growth factor a (VEGF-A) is known to drive DA specification and formation, the kinases involved in this process remain ambiguous. Thus, we investigated the role of protein kinase B (Akt) in zebrafish by generating a quadruple mutant (aktΔ/Δ), in which expression and activity of all Akt genes – akt1, -2, -3a and -3b – are strongly decreased. Live imaging of developing aktΔ/Δ DA uncovers early arteriovenous malformations. Single-cell RNA-sequencing analysis of aktΔ/Δ endothelial cells corroborates the impairment of arterial, yet not venous, cell specification. Notably, endothelial specific expression of ligand-independent activation of Notch or constitutively active Akt1 were sufficient to re-establish normal arterial specification in aktΔ/Δ. The Akt loss-of-function mutant unveils that Akt kinase can act upstream of Notch in arterial endothelial cells, and is involved in proper embryonic artery specification. This sheds light on cardiovascular development, revealing a mechanism behind congenital malformations.
Historic obstacles and emerging opportunities in the field of developmental metabolism – lessons from Heidelberg
Authors: Garfinkel Alexandra M. , Ilker Efe , Miyazawa Hidenobu , Schmeisser Kathrin , Tennessen Jason M. 
Published: August 2024

ABSTRACT
The field of developmental metabolism is experiencing a technological revolution that is opening entirely new fields of inquiry. Advances in metabolomics, small-molecule sensors, single-cell RNA sequencing and computational modeling present new opportunities for exploring cell-specific and tissue-specific metabolic networks, interorgan metabolic communication, and gene-by-metabolite interactions in time and space. Together, these advances not only present a means by which developmental biologists can tackle questions that have challenged the field for centuries, but also present young scientists with opportunities to define new areas of inquiry. These emerging frontiers of developmental metabolism were at the center of a highly interactive 2023 EMBO workshop ‘Developmental metabolism: flows of energy, matter, and information’. Here, we summarize key discussions from this forum, emphasizing modern developmental biology's challenges and opportunities.
Current State of Evidence-Based Long-Term Monitoring Protocols for Breast Plastic Surgery Patients
Authors: Ho Isabel W. , Chichura Anna , Pederson Holly J. , Xavier Brian A. , Ritner Julie , Schwarz Graham S. 
Published: August 2024

Abstract
Background
Recommendations for breast surveillance following breast plastic surgery are frequently changing. Establishing guidelines for long-term monitoring protocols may help identify treatable conditions and prevent untoward sequelae. We sought to evaluate the current state of evidence-based long-term monitoring protocols for patients following breast augmentation, reduction, and breast reconstruction.

Methods
Official guidelines from various American societies and international societies were analyzed for alignment in evidence-based recommendations regarding breast surveillance.

Results
The most recent US FDA update recommends magnetic resonance imaging or ultrasound starting 5–6 years after surgery and every 2–3 years thereafter. Discrepancies exist among professional societies: the American Society of Plastic Surgeons (ASPS) aligns with the FDA, while the American Society of Breast Surgeons and American College of Radiology (ACR) find no role for imaging for asymptomatic cases. Ultrasound is first-line for any implant concerns, with MRI if necessary. European societies oppose routine breast implant imaging. Breast reduction patients lack unique screening protocols; monitoring aligns with age and cancer risk factors. Following mastectomy and breast reconstruction, most organizations advocate for annual clinical examinations, with more frequent examinations initially. Evidence suggests that physical examination is sufficient to detect local cancer recurrence, with imaging only indicated if there is concern for recurrence. No surveillance imaging is recommended by the American Society of Clinical Oncology, National Comprehensive Cancer Network, or ASPS; however, ACR recommends mammography for autologous reconstruction only.

Conclusion
Multispecialty and regulatory body alignment may promote provider and patient adherence. Ongoing studies of long-term outcomes are needed to strengthen the level of evidence for monitoring guidelines.
Transgender Athlete Participation in Sport: Misplaced Fear and the Harms of Exclusion
Authors: Phillips Robert S. , Ryder Lee R. , Jackson Clark Ebony 
Published: August 2024

Abstract
As physical therapists and exercise professionals, we have an obligation to promote health and well-being through participation in sport and recreational/physical activity. We play an active role in facilitating and encouraging movement for a large percentage of the population, including our transgender patients/clients. It is integral that we include transgender individuals in supportive and inclusive atmospheres of play, and it is critical for us to lead the conversation around the inclusion of the transgender community in recreational activities and sport. This commentary provides evidence for the physical therapy community to support, advocate for, and include all populations as we promote healthy habits through sport.
Elementos para uma análise grafemática de tempos pretéritos: uma experiência metodológica aplicada a um manuscrito oitocentista
Authors: Silva Adilson 
Published: August 2024

Este artigo tem como objetivo apresentar uma experiência metodológica, pautada no estudo grafemático da representação dos fonemas /z/, /s/ e /ʃ/, a partir da edição semidiplomática do Livro de Razão do Campo Seco, manuscrito produzido entre 1794 e 1838, por três pessoas da família Pinheiro Canguçu (Antônio Pinheiro Pinto, Inocêncio José Pinheiro Pinto e Miguel Joaquim de Castro Mirante[1]) em Bom Jesus dos Meiras, atual cidade de Brumado. Para tanto, caracterizamos , brevemente, o manuscrito, definindo-o, destacando o suporte material e o perfil dos principais scriptores - Antônio Pinheiro Pinto, Inocêncio José Pinheiro Pinto. Em seguida, demostramos como o conhecimento da história da ortografia portuguesa e o conjunto de evidências metalinguísticas da época do documento, além da identificação do grau de escolarização dos scriptores, são fatores essenciais para a análise grafemática de tempos pretéritos. Os resultados obtidos revelam que os scriptores do Campo Seco espelham no Livro de Razão uma produção gráfica semelhante ao que circulava nos jornais, dicionários e cartas de letrados ilustres consultados. Os dados reforçam a hipótese de ortografia pendular defendida por Barbosa (1999) e descontroem a ideia de que os senhores o Campo Seco tinham pouca escolarização, já que possuíam pouco conhecimento linguístico, conforme Santos Filho (2012).
Infection and biogeographical characteristics of Paragonimus westermani and P. skrjabini in humans and animal hosts in China: A systematic review and meta-analysis
Authors: Liu Kai , Sun Yuan-Chao , Pan Rui-Tai , Xu Ao-Long , Xue Han , Tian Na , Zheng Jin-Xin , Shi Fu-Yan , Lu Yan , Li Lan-Hua 
Published: August 2024

Background
Paragonimiasis, primarily caused by Paragonimus westermani and P. skrjabini in China, is a common food-borne parasitic zoonosis. However, the national distribution of Paragonimus spp. infection and its associated environmental determinants remain poorly understood. In this paper, we summarize the infection of P. westermani and P. skrjabini and describe key biogeographical characteristics of the endemic areas in China.

Methods
Data on Paragonimus infection in humans and animal hosts were extracted from eight electronic databases, including CNKI, CWFD, Chongqing VIP, SinoMed, Medline, Embase, PubMed, and Web of Science. A random-effects meta-analysis model was used to estimate the pooled prevalence. All survey locations were georeferenced and plotted on China map, and scatter plots were used to illustrate the biogeographical characteristics of regions reporting Paragonimus infection.

Results
A total of 28,948 cases of human paragonimiasis have been documented, with 2,401 cases reported after 2010. Among the 11,443 cases with reported ages, 88.05% were children or adolescents. The pooled prevalence of P. skrjabini is 0.45% (95% CI: 0.27–0.66%) in snails, 31.10% (95% CI: 24.77–37.80%) in the second intermediate host, and 20.31% (95% CI: 9.69–33.38%) in animal reservoirs. For P. westermani, the pooled prevalence is 0.06% (95% CI: 0.01–0.13%) in snails, 52.07% (95% CI: 43.56–60.52%) in the second intermediate host, and 21.40% (95% CI: 7.82–38.99%) in animal reservoirs. Paragonimus are primarily distributed in regions with low altitude, high temperature, and high precipitation. In northeastern China, only P. westermani infections have been documented, while in more southern areas, infections of both P. westermani and P. skrjabini have been reported.

Conclusions
Paragonimiasis remains prevalent in China, particularly among children and adolescents. Variations exist in the intermediate hosts and geographical distribution of P. westermani and P. skrjabini. Additionally, altitude, temperature, and precipitation may influence the distribution of Paragonimus.
Cryogenically treated goat and human hair reinforced hybrid polymer composites
Authors: Thasthagir M Syed , R Ramesh Kumar , Mariappan Mathanbabu , Senthamaraikannan P. 
Published: August 2024

Composites of epoxy resin reinforced with goat and human hair were obtained and subjected to cryogenic processing for 24 hours at temperature 77 K. Morphological (SEM), mechanical and thermogravimetric analyses (TGA) were performed. The best properties were obtained by using a reinforcement consisting of 60 wt% human hair and 40 wt% goat hair. The SEM confirmed good interactions at the interface for this composite.