bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancements in Functional Nanomaterials Inspired by Viral Particles
Authors: Sun Xianxun , Lian Yindong , Tian Tao , Cui Zongqiang 
Published: July 2024

AbstractVirus‐like particles (VLPs) are nanostructures composed of one or more structural proteins, exhibiting stable and symmetrical structures. Their precise compositions and dimensions provide versatile opportunities for modifications, enhancing their functionality. Consequently, VLP‐based nanomaterials have gained widespread adoption across diverse domains. This review focuses on three key aspects: the mechanisms of viral capsid protein self‐assembly into VLPs, design methods for constructing multifunctional VLPs, and strategies for synthesizing multidimensional nanomaterials using VLPs. It provides a comprehensive overview of the advancements in virus‐inspired functional nanomaterials, encompassing VLP assembly, functionalization, and the synthesis of multidimensional nanomaterials. Additionally, this review explores future directions, opportunities, and challenges in the field of VLP‐based nanomaterials, aiming to shed light on potential advancements and prospects in this exciting area of research.
Time‐Resolved Evaluation of L‐Dopa Metabolism in Bacteria‐Host Symbiotic System and the Effect on Parkinson's Molecular Pathology
Authors: Kim Doyeon , Nguyen Tin Tin Manh , Moon Yechan , Kim Jin‐Mo , Nam Hoonsik , Cha Dong Seok , An Yong Jin , de Guzman Arvie Camille V. , Park Sunghyouk 
Published: July 2024

AbstractThe gut microbiome influences drug metabolism and therapeutic efficacy. Still, the lack of a general label‐free approach for monitoring bacterial or host metabolic contribution hampers deeper insights. Here, a 2D nuclear magnetic resonance (NMR) approach is introduced that enables real‐time monitoring of the metabolism of Levodopa (L‐dopa), an anti‐Parkinson drug, in both live bacteria and bacteria‐host (Caenorhabditis elegans) symbiotic systems. The quantitative method reveals that discrete Enterococcus faecalis substrains produce different amounts of dopamine in live hosts, even though they are a single species and all have the Tyrosine decarboxylase (TyrDC) gene involved in L‐dopa metabolism. The differential bacterial metabolic activity correlates with differing Parkinson's molecular pathology concerning alpha‐synuclein aggregation as well as behavioral phenotypes. The gene's existence or expression is not an indicator of metabolic activity is also shown, underscoring the significance of quantitative metabolic estimation in vivo. This simple approach is widely adaptable to any chemical drug to elucidate pharmacomicrobiomic relationships and may help rapidly screen bacterial metabolic effects in drug development.
Comparative Study of Powdered Activated Carbon and Granular Activated Carbon in Metaldehyde Adsorption: Unraveling Isotherm and Kinetic Insights
Authors: Kamarudin Nur Salsabila , Dahalan Farrah Aini , Zubir Arina Azmina Ahmad , Hasan Masitah , Ibrahim Naimah , Lutpi Nabilah Aminah , Nazri Raja Nazrul Hakim Raja , Parmin Nor Azizah 
Published: July 2024

ABSTRACTSlug pellets contain metaldehyde, a potent substance that kills molluscs, which also harms the environment and human health by polluting water systems. Metaldehyde removal from wastewater has emerged as a possible treatment strategy utilizing activated carbon materials such as powdered activated carbon (PAC) and granular activated carbon (GAC). This study aims to compare and analyze the adsorption mechanisms and kinetics of these materials. SEM studies of PAC and GAC revealed unique morphological characteristics, with PAC having a finely textured surface and a well‐defined porosity structure, and GAC having a granular structure with irregularly shaped particles. According to the BET analysis, PAC had a larger surface area and pore volume than GAC, which had a lower surface area and pore volume. The FTIR spectra of PAC and GAC samples reveal different types of bonds such as ―OH, O―H, C―H, C═O, C═C, and C―O which potentially affect their reactivity and interaction with metaldehyde. PAC performed better than GAC in removing metaldehyde from water, as it had a higher surface area and a wider range of pore sizes. The Langmuir isotherm and the pseudo‐second‐order kinetic model fit the experimental data well for this adsorption study.
Plasmainduzierte Schichtnachbearbeitung
Authors: Brückner S. , Tasche D. , Bellmann M. , Josten S. , Wittland F. , Zeiß B. , Gerhard C. 
Published: July 2024

ZusammenfassungEinbrennsilikonschichten (EBS) stellen ein hervorragendes Medium zur Generierung chemisch weitestgehend inerter und biologisch unschädlicher reibungsarmer Oberflächen dar. Die unter Umständen vorhandene Not‐wendigkeit von der EBS‐Beschichtung nachgeschalteten Fügeprozessen erfordert für das Erreichen stabiler Klebeverbindungen jedoch entweder die nachträgliche, meist ortsselektive Entfernung oder eine funktionale Modifikation der EBS‐Schicht. In der vorliegenden Studie konnte gezeigt werden, dass sich EBS‐Schichten durch die Anwendung eines Niedertemperaturplasmas bei Atmosphärendruck in glasähnliche, nahezu kohlenstofffreie Schichten umwandeln lassen. Diese Umwandlung wird dabei von einer Schichtdickenreduktion von ca. 50 % begleitet. Als Folge davon tritt eine deutlich gesteigerte Adhäsion von Klebstoffen auf der plasmabehandelten EBS‐Schicht auf.
Association of ACE2 and TMPRSS2 towards COVID-19 susceptibility
Authors: Alam Naveed , Lodhi Ghulam Mustafa , Khan Umar Ali , Zia Amn , Azam Maleeha , Khan Jadoon , Shah Tawaf Ali , Okla Mohammad K. , younous Youssouf Ali , Bourhia Mohammed 
Published: July 2024

AbstractSevere Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) is pneumonia like viral disease which was originated from Wuhan China in 2019. Besides its high morbidity and mortality, a lot of physiological, enzymatic, hormonal and genetic imbalances had also been observed among Corona Virus Disease-19 (COVID-19) patients. The purpose of the present study was the assessment of comorbidities and association of single nucleotide polymorphisms (SNPs) in Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine (TMPRSS) gene among COVID-19 patients. A total of 300 (healthy control n = 150 COVID-19 n = 150) individuals were sampled and genotyped for ACE2 rs2285666 and TMPRSS rs2070788 SNPs respectively. A total of 92/150 (61.3%) were male infected population, among the various age groups (age group 1: 1–15 yrs; age group 2: 16–30 yrs; age group 3: 31–45; age group 4: 46 and above) where most of the patients were from age group 4 (46 and above) 79/150 (52.7%) followed by age group 3 (31–45) 44/150 (29.3%). Logistic regression analysis showed that among clinical features cough (90%) was observed to be highest followed by fever (80%), sore throat (76%) and shortness of breath (75%). Hypertension (51%), type II diabetes (48.4%), ischemic heart disease (43.3%) history was found to prevalent highly associated with infected individuals. For ACE2 rs2285666, we found disease risk association for both allele and genotype while TMPRSS did not reveal genotype association. It is concluded from the current study that COVID-19 infects majority of male population. ACE2 rs2285666 allele and genotype association was observed with COVID-19 infection and protective association of TMPRSS2 rs2070788 allele towards COVID-19 infection.
Characterization of problematic subsurface soils in Eha-Amufu using integrated investigation approach: implications for earth works
Authors: Ayogu Nnadozie Onyekachi , Igwe Ogbonnaya , Onuoha Mosto Kalu 
Published: July 2024

AbstractMapping of the subsurface is a vital procedure during construction. It enhances hazard zonation, planning and protection of engineering structures. The present study centres on an area susceptible to foundation instability and building collapse in Enugu State, southeastern Nigeria. The study followed an integrated research method by employing a geotechnical approach and geophysical surveys such as electrical resistivity and remote sensing performed using Landsat, Aeromagnetic and shuttle radar topography mission (SRTM) images. Geotechnical data revealed that the subsurface comprised soils with higher fines (69%) than coarse (31%) grain sizes, high liquid limit (27–76%), plasticity index (9–46%), natural moisture content (6.0–14.8%) as well as low specific gravity (2.49–2.67) and coefficient of permeability (2.27 × 10–8–1.81 × 10–4 cm/s). Shear strength parameters- cohesion (13–35 kPa) and internal friction angle (9–21°) were low to moderate as well as the coefficient of consolidation (0.04–3.84 m2/mN) and coefficient of volume compressibility (0.05–0.29 m2/year). These properties are reminiscent of silty-clay soil of high plasticity and compressibility. The low soil resistivity with values ranging between 10 and 170 Ωm and aeromagnetic signal strength of 8.74 × 10–5 nT/km confirmed the silty-clay classification. The moderate to high lineament density determined from the remote sensing methods indicates the influx of moisture from higher surrounding grounds into the area to initiate high groundwater regime and flooding as observed in the fieldwork, which consequently triggers the activity of clay minerals present in the clay.
Rise of the beta-lactams: a retrospective, comparative cohort of oral beta-lactam antibiotics as step-down therapy for hospitalized adults with acute pyelonephritis
Authors: Hobbs Athena L.V. , Hemmige Vagish S. , Reel Katie L. , Jaso Theresa C. , Rose Dusten T. , Shea Katherine M. 
Published: July 2024

Abstract

Objective:
The aim of this study was to determine if oral beta-lactam therapy is non-inferior to alternative therapy at discharge following inpatient treatment with an IV cephalosporin for acute pyelonephritis.

Design:
Institutional Review Board (IRB)-approved, multicenter, retrospective, non-inferiority cohort (15% non-inferiority margin).

Setting:
Six hospitals within two healthcare systems.

Patients:
Hospitalized patients admitted to the medical floor with acute pyelonephritis without urologic abnormalities who received cefazolin or ceftriaxone followed by step-down therapy.

Methods:
Patients were discharged with either an oral beta-lactam or an oral alternative agent (ie, fluoroquinolone or trimethoprim-sulfamethoxazole) to complete therapy. The primary objective was treatment failure defined as a composite of hospital readmission or an ED visit for a urinary cause within 30 days of discharge of the index hospitalization. Data were extracted manually from the electronic medical record.

Results:
A total of 211 patients were included; 122 received an oral beta-lactam and 89 received an oral alternative agent at discharge. There was no difference in 30-day treatment failure between the two groups (4.9% vs 5.6% for oral beta-lactams vs oral alternatives, respectively. Absolute difference = 0.7%; 95% CI -5.4% to 6.8%; P = .82). The median length of hospital stay, number of patients treated with intravenous ceftriaxone, duration of IV therapy, and median duration of oral therapy were no different between groups.

Conclusions:
In non-ICU patients admitted for pyelonephritis without urologic abnormalities, oral beta-lactams were non-inferior to oral alternatives for step-down therapy. In finding non-inferiority between the regimens, we show the feasibility of administering oral beta-lactams to complete therapy for acute pyelonephritis.
Healthcare staff perceptions of an electronic hand hygiene monitoring system within a large university system
Authors: Elliott Rachel , Fetibegovic Emina , Briggs Julie , Shaw Jana , Suits Paul , Wong Roger , Stewart Telisa 
Published: July 2024

Abstract

Objective:
The acceptability of an electronic HH monitoring system (EHHMS) was evaluated among hospital staff members.

Design:
An electronic HH monitoring system was implemented in June 2020 at a large, academic medical center. An interdisciplinary team developed a cross-sectional survey to gather staff perceptions of the EHHMS.

Setting:
The survey was conducted at a public, tertiary acute care hospital.

Participants:
The survey included current employees and staff. 1,273 participants responded. The mean age was 44.9 years (SD = 13.5). Most of the samples were female (71%) and non-Hispanic white (83%).

Methods:
A survey was conducted between June and July 2021. Responses were analyzed using Stata statistical software. Multiple logistic regression models were constructed to examine factors associated with negative perceptions of the EHHMS and its radiofrequency identification (RFID) badge. Supporting qualitative analyses were performed using Atlas.ti version 9.

Results:
Three-quarters (75%) of respondents reported neutral to negative perceptions of the EHHMS and its associated badge. Respondents reported limited influence on HH practices. Age, campus location, length of employment, job role, and opinion on data sharing were associated with negative perceptions of the EHHMS and RFID badge. Position in a direct patient care role was associated with negative perceptions of the RFID badge.

Conclusions:
Perceptions of the EHHMS aligned with previous research. Identified associations provide opportunities for targeted education, outreach, and intervention to increase acceptability and uptake. Lack of acceptance is explained by poorly perceived ease of use and usefulness, as well as challenges in implementation.
First record of the brachiopod Argyrotheca cuneata from a nearshore habitat at the southern coast of Türkiye
Authors: Örstan Aydin 
Published: July 2024

Abstract
The brachiopod Argyrotheca cuneata (Brachiopoda: Megathyrididae) is reported for the first time from the southern coast of Türkiye. Twenty-three complete specimens were found in samples of shell grit taken from depths less than 5 m. The findings suggest that A. cuneata may be a common brachiopod species in shallow nearshore habitats along the southern coasts of the country. Widths of the largest and the smallest specimens were 3.7 mm and 0.71 mm, respectively. A comparison of shell dimensions of all specimens indicate an allometric change in the shape of A. cuneata during growth from being longer than wide to wider than long. The protegula preserved on the smallest specimens are described and illustrated possibly for the first time for this species.
The first record of the parasite Peltogaster lineata (Rhizocephala: Peltogastridae) on the hermit crab Pagurus middendorffii (Anomura: Paguridae)
Authors: Golubinskaya Darya D. , Sharina Svetlana N. , Korn Olga M. , Arbuzova Natalia A. 
Published: July 2024

Abstract
In Peter the Great Bay (Russian waters of the Sea of Japan), rhizocephalan barnacle Peltogaster lineata Shiino, 1943, a common parasite of the hermit crab Pagurus brachiomastus (Thallwitz, 1891), was founded for the first time on the hermit crab Pagurus middendorffii Brandt, 1851 (Anomura: Paguridae). Taxonomical identification of the parasite was made using morphological and molecular methods. Pagurus middendorffii is the sixth host of P. lineata.
Assessing external exposome by implementing an Environmental Data Management System using Open Data
Authors: Tagliaferro Sofia , Maio Sara , Pirona Federico , Stanisci Ilaria , Sarno Giuseppe , Silvi Patrizia , Kermenidou Marianthi , Papaioannou Nafsika , Perchard Reena , Prpic Igor , Polanska Kinga , Jerzynska Joanna , Ramos Elisabete , Rovira Joaquim , Belmonte Jordina , Snoj Tratnik Janja Snoj , Horvat Milena , Kocman David , Spiric Zdravko , Zickella Jacqueline , Fasola Salvatore , La Grutta Stefania , Malizia Velia , Montalbano Laura , Keijser Bart , Kieboom Jasper , Larsen Martin , Schumacher Marta , van den Broek Tim , Villette Rémy , Baiz Nour , Barros Henrique , Bartzis John , Ahmad Norhidayah Binti , Bocca Beatrice , Brescianini Sonia , Calamandrei Gemma , Chatzimpaloglou Anthoula , Dogliotti Eugenia , Falnoga Ingrid , Fonseca Maria João , Gabriel Catherine , Gamil Amir , Gotti Alberto , Hanke Wojciech , Johnstone Edward , Jurewicz Joanna , Kabesch Michael , Kalska-Sochacka Katarzyna , Karakitsios Spyros , Kocman David , Kumar Vikas , Mazej Darja , Mazzei Filomena , Meccia Ettore , Minghetti Luisa , Nisticò Lorenza , de Oliveira Fernandes Eduardo , Perchard Reena , Pino Anna , Sarigiannis Dimosthenis , Schumacher Marta , Stazi Maria Antonietta , Szcześniak Kamila , Tancredi Patrizia , Silva Gabriela Ventura , Viegi Giovanni , Baldacci Sandra , Annesi-Maesano Isabella ,   EarlyFOOD,   HEALS EXHES
Published: July 2024

AbstractDue to the increasing importance of exposome in environmental epidemiology, feasibility and usefulness of an Environmental Data Management System (EDMS) using Open Data was evaluated. The EDMS includes data from 10 European cities (Celje (Slovenia), Łódź (Poland), Manchester (UK), Palermo (Italy), Paris (France), Porto (Portugal), Regensburg (Germany), Reus (Spain), Rijeka (Croatia), Thessaloniki (Greece)) about external non-specific and specific exposome factors at the city or country level (2017–2020). Findings showed that the highest values of life expectancy were in Reus females (86 years) and Palermo males (81 years). UK had the highest obesity rate (28%), Croatia the highest prescribed drug consumption (62%), Greece and Portugal the highest smoking rates (37%, 42%) and daily alcohol consumption (21%), respectively. The most polluted cities were Thessaloniki for PM10 (38 µg/m3), Łódź for PM2.5 (25 µg/m3), Porto for NO2 (62 µg/m3) and Rijeka for O3 (92 µg/m3). Thessaloniki had the highest grey space (98%) and Łódź the highest cumulative amount of pollen (39,041 p/m3). The highest daily noise levels ≥ 55 dB was in Reus (81% to traffic) and Regensburg (21% to railway). In drinking water, arsenic had the highest value in Thessaloniki (6.4 µg/L), boron in Celje (24 mg/L) and lead in Paris (46.7 µg/L). Portugal and Greece showed the highest pesticide residues in food (7%). In conclusion, utilizing open-access databases enables the translation of research findings into actionable strategies for public health interventions.
Time to adequate weight gain and predictors among low-birth-weight preterm neonates at Neonatal Intensive Care Unit of hospitals in Bahir-Dar
Authors: Tigabu Dagnew , Gezie Hailemariam , Baye Fekadie Dagnew , Birhanu Shiferaw , Workie Hailemariam Mekonnen 
Published: July 2024

AbstractWeight gain in low birth-weight babies remains a challenge to the management of the neonatal period in low and middle-income countries like Ethiopia. Therefore, this study aimed to determine the time to adequate weight gain and its predictors among low-birth-weight preterm neonates admitted to neonatal intensive care unit of public hospitals in Bahir Dar City. An institution-based retrospective follow-up study was conducted from March 4 to April 3, 2023, using three years of data. About 344 low-birth-weight preterm babies were recruited and followed up until 28 days of age. Model goodness-of-fit was checked by Cox Snell residuals test. The Cox-Proportional Hazards Model was used to assess predictors of weight gain with a statistically significant level of P-value < 0.05. The median weight gain time was 15 days with an overall incidence density rate of 6.3 per 100 person-day of observation (95% CI 0.055, 0.071). Absence of medical problems of mothers (AHR: 1.63, 95% CI 1.015, 4.614), spontaneous vaginal mode of delivery (AHR: 1.53, 95% CI 1.028, 2.593), and long duration of labor (AHR: 3.18, 95% CI 1.579, 6.413) were significant predictors. The time of adequate weight gain was long. Early detection and management of significant predictors is recommended.
Energy-efficient quad tree-based clustering using edge-assisted UAV-relay to enhance network lifetime in WSN
Authors: Prasad K. H. Vijayendra , Sasikumar P. 
Published: July 2024

AbstractWireless sensor networks' most prominent concern is energy optimization. It faces significant problems like high energy consumption, data loss, delay, and low network lifetime. To improve, it uses clustering. However, during clustering, coverage holes are most likely to appear near the network's edge, within the cluster, and between clusters. As a result, there are more energy holes and dead nodes; therefore, the goal of this work is to maximize node network lifetime and minimize energy consumption during data transmission in the wireless sensor network (WSN). The proposed work includes three entities: sensor nodes, an edge-assisted unmanned aerial vehicle (UAV), and a base station. It uses an edge-assisted unmanned aerial vehicle to provide additional resources to the UAV, which helps reduce energy consumption during data transmission. This research proposes using communication to enhance the speed and bandwidth of data transmission and reduce transmission latency. This work attempts to improve performance by increasing throughput.
Adaptation and psychometric investigation of the Gameful Experience Questionnaire (GAMEFULQUEST) in Brazilian Portuguese
Authors: Oliveira da Silva Junior Luiz , Oliveira Wilk , Hamari Juho 
Published: July 2024

AbstractOver the years, the use of questionnaires has become one of the most used methods for analyzing individuals’ experiences. Especially in the area of gameful environments (e.g., games, gamification, and simulators), the Gameful Experience Questionnaire, a self-report instrument to measure gameful experience, became one of the most popular. Despite the instrument’s popularity, there is no Brazilian Portuguese version, preventing studies from being carried out in Brazil (i.e., a country with more than 200 million inhabitants), where only 5.1% of the population have adequate English comprehension skills. To face this challenge, we conducted a cross-cultural adaptation of the Gameful Experience Questionnaire, providing a version of the questionnaire in the Brazilian Portuguese language. For this process, we conducted a mixed-methods (i.e., qualitative and quantitative) psychometric study (N = 384) organized in six steps (i.e., (i) translation, (ii) synthesis, (iii) experts evaluation, (iv) target audience evaluation, (v) adapted instrument application, and (vi) validation (i.e., confirmatory factor analysis)). The results indicate that the cross-cultural adaptation took place efficiently, where the resulting instrument maintained the psychometric properties of the original, measuring the construct of interest with similar effectiveness (i.e., $$\chi ^2/df$$

χ
2

/
d
f

= 2.4, RMSEA = 0.061, CFI = 0.991, TLI = 0.989, GFI = 0.986 and SRMR = 0.061), enabling its application with Brazilian Portuguese speakers. With this study, we contribute to researchers and practitioners in the field of gameful environments by providing an instrument to measure gameful experience in the Brazilian Portuguese language.