bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating current clinical opinions in stereoelectroencephalography‐informed epilepsy surgery
Authors: Thomas John , Abdallah Chifaou , Cai Zhengchen , Jaber Kassem , Gotman Jean , Beniczky Sandor , Frauscher Birgit 
Published: August 2024

AbstractObjectiveStereoelectroencephalography (SEEG) is increasingly utilized worldwide in epilepsy surgery planning. International guidelines for SEEG terminology and interpretation are yet to be proposed. There are worldwide differences in SEEG definitions, application of features in epilepsy surgery planning, and interpretation of surgical outcomes. This hinders the clinical interpretation of SEEG findings and collaborative research. We aimed to assess the global perspectives on SEEG terminology, differences in the application of presurgical features, and variability in the interpretation of surgery outcome scores, and analyze how clinical expert demographics influenced these opinions.MethodsWe assessed the practices and opinions of epileptologists with specialized training in SEEG using a survey. Data were qualitatively analyzed, and subgroups were examined based on geographical regions and years of experience. Primary outcomes included opinions on SEEG terminology, features used for epilepsy surgery, and interpretation of outcome scores. Additionally, we conducted a multilevel regression and poststratification analysis to characterize the nonresponders.ResultsA total of 321 expert responses from 39 countries were analyzed. We observed substantial differences in terminology, practices, and use of presurgical features across geographical regions and SEEG expertise levels. The majority of experts (220, 68.5%) favored the Lüders epileptogenic zone definition. Experts were divided regarding the seizure onset zone definition, with 179 (55.8%) favoring onset alone and 135 (42.1%) supporting onset and early propagation. In terms of presurgical SEEG features, a clear preference was found for ictal features over interictal features. Seizure onset patterns were identified as the most important features by 265 experts (82.5%). We found similar trends after correcting for nonresponders using regression analysis.SignificanceThis study underscores the need for standardized terminology, interpretation, and outcome assessment in SEEG‐informed epilepsy surgery. By highlighting the diverse perspectives and practices in SEEG, this research lays a solid foundation for developing globally accepted terminology and guidelines, advancing the field toward improved communication and standardization in epilepsy surgery.
The impacts of anti‐genderism on education in Brazil: Fear and danger among professors of gender
Authors: Huerta Moreno Lydia , Blithe Sarah Jane , Balthazar Gregory da Silva 
Published: August 2024

AbstractThis paper examines the influence of right‐wing political ideologies on the lives and experiences of university professors who teach about women and gender in their respective disciplines throughout Brazil. Drawing from qualitative interviews with professors in different regions of Brazil we argue that the embrace of anti‐gender ideologies by the Bolsonaro administration has had a negative impact on university educators by restricting resources, increased surveillance, threats, and attacks.
Impact of different lactic acid bacteria on nitrite degradation and quality of fermented carrot
Authors: Li Meng‐Na , Yao Qing‐Bo , Zhang Hong‐Rui , Li Wen‐Qi , Nie Jing , Liang Qi‐Chun , Wang Lang‐Hong , Zeng Xin‐An , Huang Yan‐Yan 
Published: August 2024

SummaryIn this study, six groups of carrots were designed and fermented using Weissella paramensenteroides MbWp142 (WP), Levilactobacillus brevis GDMCC 1.773 (LS), Leuconostoc mesenteroides GDMCC 1.774 (SE), mixed fermentation of three lactic acid bacteria (WP + LS + SE), pasteurisation group (BG) and natural fermentation group (CK). GC–MS results indicated that inoculation of WP + LS + SE increased the types and contents of flavour substances such as alcohols, esters and hydrocarbons. Compared with other experimental groups, the peak nitrite value in the LS group was lower due to the production of organic acids by lactic acid bacteria. Sensory evaluation revealed that the quality and flavour of carrot fermented by LS were superior to those fermented by SE, WP and WP + LS + SE. Therefore, Levilactobacillus brevis used as a starter for fermenting carrot can enhance product quality and reduce nitrite accumulation during fermentation.
PLCL/SF/NGF nerve conduit loaded with RGD‐TA‐PPY hydrogel promotes regeneration of sciatic nerve defects in rats through PI3K/AKT signalling pathways
Authors: Liu Kunyu , Tang Weilong , Jin Shixin , Hao Xin , Hu Yuhang , Zhou Tianyi , Zhou Chenliang , Chen Guanghua , Cui Yifeng , Liu Qianqi , Zhang Zhenyu 
Published: August 2024

AbstractPeripheral nerve defect are common clinical problem caused by trauma or other diseases, often leading to the loss of sensory and motor function in patients. Autologous nerve transplantation has been the gold standard for repairing peripheral nerve defects, but its clinical application is limited due to insufficient donor tissue. In recent years, the application of tissue engineering methods to synthesize nerve conduits for treating peripheral nerve defect has become a current research focus. This study introduces a novel approach for treating peripheral nerve defects using a tissue‐engineered PLCL/SF/NGF@TA‐PPy‐RGD conduit. The conduit was fabricated by combining electrospun PLCL/SF with an NGF‐loaded conductive TA‐PPy‐RGD gel. The gel, synthesized from RGD‐modified tannic acid (TA) and polypyrrole (PPy), provides growth anchor points for nerve cells. In vitro results showed that this hybrid conduit could enhance PC12 cell proliferation, migration, and reduce apoptosis under oxidative stress. Furthermore, the conduit activated the PI3K/AKT signalling pathway in PC12 cells. In a rat model of sciatic nerve defect, the PLCL/SF/NGF@TA‐PPy‐RGD conduit significantly improved motor function, gastrocnemius muscle function, and myelin sheath axon thickness, comparable to autologous nerve transplantation. It also promoted angiogenesis around the nerve defect. This study suggests that PLCL/SF/NGF@TA‐PPy‐RGD conduits provide a conducive environment for nerve regeneration, offering a new strategy for peripheral nerve defect treatment, this study provided theoretical basis and new strategies for the research and treatment of peripheral nerve defect.
Influence of viscosity and fiber reinforcement of resin composite on fracture strength and failure mode of restored molars
Authors: Borges Karin Tyeme , Servín María Paz Méndez , França Fabiana Mantovani Gomes , Turssi Cecilia Pedroso , Basting Roberta Tarkany , Hirata Ronaldo , Vieira‐Junior Waldemir Francisco 
Published: August 2024

AbstractObjectiveTo evaluate the fracture behavior of human molars with extensive MOD restorations using short‐fiber‐reinforced resin composite of varying viscosities.Materials and MethodsHuman molars were randomly divided into seven groups (n = 12): intact teeth (control); restoration using conventional high‐viscosity resin composite without (Filtek Z350XT, 3M) or with fibers (everX Posterior, GC); conventional low‐viscosity resin composite without (Filtek Supreme Flowable, 3M) or with fibers (everX Flow Dentin Shade, GC); bulk‐fill low‐viscosity resin composite (Filtek Bulk Fill Flow, 3M) or with fibers (everX Flow Bulk Shade, GC). Restorations were performed on extensive MOD preparations, following the manufacturers' recommendations for each material. Specimens underwent fracture strength testing (N) and fracture pattern (%) categorized as repairable, possibly repairable, or non‐repairable. Results were analyzed using a generalized linear model (N) and Fisher's exact test (%), with α = 0.05.ResultsRestorations performed with high‐viscosity materials showed fracture strength values similar to the control and higher than those of restorations using low‐viscosity resin composites (p < 0.0001), except for the bulk‐fill low‐viscosity resin composite with fibers (p > 0.05). Teeth restored using low‐viscosity resin composite with fibers showed a higher % of repairable and possibly repairable fractures than the control (p = 0.0091).ConclusionsThe viscosity of materials mediated the fracture strength, with restorations using high‐viscosity resin composites promoting values similar to the intact tooth; however, the presence of fibers influenced the fracture pattern.Clinical SignificanceTeeth with MOD cavities restored with high‐viscosity resin composites showed similar fracture strength to intact teeth. Fiber‐reinforced low‐viscosity resin composite for the base of restoration resulted in a more repairable/possibly repairable fracture pattern.
Vulnerabilities of the neoliberal global food system: The Russia–Ukraine War and COVID‐19
Authors: Yıldırım Cuma , Önen Hakkı Göker 
Published: August 2024

AbstractThe coronavirus 2019 (COVID‐19) pandemic and the Russia–Ukraine war have demonstrated that the neoliberal system is unstable during global crises. In times of crisis, exporter countries adopt protectionist policies in the form of export restrictions to safeguard their local food supply and curb inflation. Consequently, low‐income countries might find themselves unable to access essential food products. In this regard, the aftermath of the COVID‐19 pandemic and the Russia–Ukraine war has gradually increased export restrictions, causing severe food supply disruptions. In particular, import‐dependent countries cannot access essential food products and face famine. To this point, this study explores the vulnerabilities of neoliberalism when exporter countries turn to protectionism. Moreover, it asks whether food sovereignty and self‐sufficiency could act as a safeguard for import‐dependent states against such vulnerabilities. In doing so, the study aims to contribute to the literature by linking protectionism with export restrictions, diverging from the more common association of protectionism with solely import restrictions.
Healthy Lifestyles Modify the Association of Melatonin Receptor 1B Gene and Ischemic Stroke: A Family‐Based Cohort Study in Northern China
Authors: Guo Huangda , Peng Hexiang , Wang Siyue , Hou Tianjiao , Li Yixin , Zhang Hanyu , Jiang Jin , Ma Bohao , Wang Mengying , Wu Yiqun , Qin Xueying , Tang Xun , Chen Dafang , Li Jing , Hu Yonghua , Wu Tao 
Published: August 2024

ABSTRACTLimited research has reported the association between MTNR1B gene polymorphisms and ischemic stroke (IS), and there is insufficient evidence on whether adopting a healthy lifestyle can mitigate genetic risks in this context. This study aimed to investigate the associations between MTNR1B gene variants (rs10830963 and rs1387153) and IS, examining the potential effect of gene–lifestyle interactions on IS risk. Conducted in northern China, this family‐based cohort study involved 5116 initially IS‐free subjects. Genotype data for rs10830963 and rs1387153 in MTNR1B were collected. Eight modifiable lifestyle factors, including body mass index (BMI), smoking, alcohol consumption, dietary habits, physical activity, sedentary time, sleep duration, and chronotype, were considered in calculating healthy lifestyle scores. Multilevel Cox models were used to examine the associations between MTNR1B variants and IS. Participants carrying the rs10830963‐G and rs1387153‐T alleles exhibited an elevated IS risk. Each additional rs10830963‐G allele and rs1387153‐T allele increased the IS risk by 36% (HR = 1.36, 95% CI, 1.12–1.65) and 32% (HR = 1.32, 95% CI, 1.09–1.60), respectively. Participants were stratified into low, medium, and high healthy lifestyle score groups (1537, 2188, and 1391 participants, respectively). Genetic–lifestyle interactions were observed for rs10830963 and rs1387153 (p for interaction < 0.001). Notably, as the healthy lifestyle score increased, the effect of MTNR1B gene variants on IS risk diminished (p for trend < 0.001). This study underscores the association between the MTNR1B gene and IS, emphasizing that adherence to a healthy lifestyle can mitigate the genetic predisposition to IS.
Flagellar protein FliL: A many‐splendored thing
Authors: Partridge Jonathan D. , Harshey Rasika M. 
Published: August 2024

AbstractFliL is a bacterial flagellar protein demonstrated to associate with, and regulate ion flow through, the stator complex in a diverse array of bacterial species. FliL is also implicated in additional functions such as stabilizing the flagellar rod, modulating rotor bias, sensing the surface, and regulating gene expression. How can one protein do so many things? Its location is paramount to understanding its numerous functions. This review will look at the evidence, attempt to resolve some conflicting findings, and offer new thoughts on FliL.
Psychogastroenterology of cyclic vomiting syndrome: A crucial need to build evidence
Authors: Tarbell Sally E. , van Tilburg Miranda A. L. 
Published: August 2024

AbstractCyclic vomiting is a disorder of gut brain interaction (DGBI) emphasizing the need for treatment of both the brain and the gut. Despite clinical success of psychological therapies for CVS, also called brain‐gut treatments, an evidence‐base is lacking and these treatments are available in few GI practices. This has resulted in an “all guts no brain” approach to CVS. The current paper is a call to action to develop more evidence and use of brain‐gut therapies in CVS.
Macrovibrissae and microvibrissae inversion and lateralization in elephants
Authors: Yildiz Hazal , Heise Olivia , Gerhardt Ben , Fritsch Guido , Becker Rolf , Ochs Andreas , Sicks Florian , Buss Peter , de Klerk‐Lorist Lin‐Mari , Hildebrandt Thomas , Brecht Michael 
Published: August 2024

AbstractElephants are known for strongly lateralized trunk behaviors, but the mechanisms driving elephant lateralization are poorly understood. Here, we investigate features of elephant mouth organization that presumably promote lateralization. We find the lower jaw of elephants is of narrow width, but is rostrally strongly elongated even beyond the jaw bone. Elephant lip vibrissae become progressively longer rostrally. Thus, elephants have two lateral dense, short microvibrissae arrays and central, less dense long macrovibrissae. This is an inversion of the ancestral mammalian facial vibrissae pattern, where central, dense short microvibrissae are flanked by two lateral macrovibrissae arrays. Elephant microvibrissae have smaller follicles than macrovibrissae. Similar to trunk‐tip vibrissae, elephant lip microvibrissae show laterally asymmetric abrasion. Observations on Asian zoo elephants indicate lateralized abrasion results from lateralized feeding. It appears that the ancestral mammalian mouth (upper and lower lips, incisors, frontal microvibrissae) is shaped by oral food apprehension. The elephant mouth organization radically changed, however, because trunk‐mediated feeding replaced oral apprehension. Such elephant mouth changes include the upper lip–nose fusion to the trunk, the super‐flexible elongated lower jaw, the loss of incisors, and lateral rather than frontal microvibrissae. Elephants’ specialization for lateral food insertion is reflected by the reduction in the centering effects of oral food apprehension and lip vibrissae patterns.
Evaluation of palate morphology in patients treated with leaf expander and hyrax expander: A geometric morphometric analysis
Authors: Silvestrini‐Biavati Francesca , Oliva Giorgio , Ghislanzoni Luis Huanca , Ottonelli Elisa , Dalessandri Domenico , Lanteri Valentina , Ugolini Alessandro 
Published: August 2024

AbstractObjectiveThe aim of this study was to evaluate changes in shape of the palatal vault after maxillary expansion with hyrax expander (HE) and leaf expander (LE), using 3D Geometric Morphometric Analysis.Setting and Sample PopulationOverall, 250 patients (110 M, 140 F) with maxillary transverse deficiency were selected for this study. In this study, 127 subjects were treated with HE, 123 with LE.Materials and MethodsDigital dental models were obtained pre‐treatment (T0) and after 12 months from the cementation of the device (T1) and processed by means of a digital scanner. Linear and morphometric analyses were conducted to determine the effects of each appliance on dental measurements and palatal shape, and a multiple linear regression was performed to analyse the influence of anchorage and appliance type on final shape.ResultsMorphometric analysis showed that there was a lowering of the palatal vault in the HE group, while in the LE group it remained unchanged: the difference in palatal shape at time T0 and T1 was statistically significant in both treatments (HE vs. LE). In the HE group, the change in shape also included the upper part of the palatal vault in the vertical dimension, while in the LE group the change in shape interested mainly palatal shelves and the lower portion of the palate.ConclusionsBoth LE and HE produce clinically significant changes in the morphology of the palatal vault.
Characteristics of sialolithiasis in Israel, a big‐data retrospective study of 5100 cases
Authors: Jonas Ehud , Muchnik Daniel , Rabinovich Idan , Masri Daya , Chaushu Gavriel , Avishai Gal 
Published: August 2024

AbstractObjectiveThe aim of this study was to identify risk factors for sialolithiasis patients using a large community and hospital‐based cohort.MethodsA retrospective case–control study was conducted on 20,396 individuals, including 5100 sialolithiasis patients and 15,296 matched controls. Demographics and laboratory data were obtained from electronic medical records. Statistical analyses were performed to identify significant differences between the two groups. A p‐value of <0.05 was considered significant.ResultsSialolithiasis was more prevalent in women, with a mean age at diagnosis of 55.75 years. Several geographic location variables emerged as risk factors for sialolithiasis including Israeli birth, higher socioeconomic communities, and specific areas of residency. Tobacco smoking (odds ratio = 1.46) was a significant risk factor. Low high‐density lipoprotein levels, elevated triglycerides, and elevated amylase levels were associated with sialolithiasis.ConclusionsThis study provides valuable insights into the demographic and laboratory characteristics of sialolithiasis patients, indicating that area of residency and lifestyle factors contribute to the risk of developing sialolithiasis. The findings may contribute to a better understanding of the disease and the development of preventative measures or early diagnostics tools.
High‐density single nucleotide polymorphism‐based linkage mapping reveals novel quantitative trait loci for rice (Oryza sativa) sheath blight resistance from wild rice (Oryza rufipogon)‐derived introgression line
Authors: Senapati Manoranjan , Tiwari Ajit , Vinod Kunnummal Kurungara , Bashyal Bishnu Maya , Amaresh  , Nagarajan Mariappan , Dhawan Gaurav , Gowda Munegowda Manoj , Ellur Ranjith Kumar , Bhowmick Prolay Kumar , Bollinedi Haritha , Singh Ashok Kumar , Subbaiyan Gopala Krishnan 
Published: August 2024

AbstractRice sheath blight is one of the most important fungal disease‐causing yield losses up to 50%. An Oryza rufipogon‐derived introgression line (Pusa 1908‐13‐12‐5) identified to be highly resistant to sheath blight was used for developing a RIL population by crossing with a highly susceptible rice cultivar, Pusa Basmati 1 (PB 1). The RIL population was genotyped with 80K Rice Pangenome (RPAN) single nucleotide polymorphism (SNP) array and phenotyped for disease response under artificial inoculation for 2 consecutive years. Inclusive composite interval mapping could identify six quantitative trait loci (QTLs) for two traits, namely, relative lesion height and relative yield loss per plant. Among these QTLs, four were major QTLs and three are novel QTLs. Three major QTLs were co‐localised within 1.4 Mb region on chromosome 1. In silico analysis revealed the presence of 12 candidate genes with potential role in disease resistance. Kompetitive Allele Specific PCR (KASP™) assay was developed for the linked SNPs and used for validation in an independent BC1F2:3 population (PB 1121/Pusa 1908‐13‐12‐5). One SNP (AX‐182186537) on chromosome 1 was validated, which offers scope for its utilisation in marker‐assisted breeding.
Plasmonic nanophotothermal therapy: Destruction of 500 mm3 subcutaneous human basal cell carcinoma with gold nanoparticles and near infrared laser
Authors: Pesnel Sabrina , Bertolotti Antoine , Duquenne Sébastien , Zahouani Hassan , Mortier Laurent , Perrot Jean‐Luc , Morel Anne‐Laure 
Published: August 2024

AbstractSignificanceMultilesional basal cell carcinoma (BCC) are spread on sun exposed skin areas, including arms, face and back. The first‐line treatment remains the surgical resection or Mohs surgery. Despite its high complexity, Mohs surgery is well practiced in USA and Germany and presents very good results both in esthetic and in carcinology point of view.Large lesions more than 2 cm remain challenging to remove by topical cream used in photodynamic therapy (PDT). If these larger lesions are not treated in less than 1 month, they could grow deeply in the skin, thus enhancing the risk of reoccurrence and the severity of the disease. Despite this model herein studied, that is non melanoma skin cancer is a good prognostic cancer, the therapy aims to be applied to more aggressive melanoma skin cancers.AimTotal regression of large cutaneous lesions less than 1 month with no reoccurrence.ApproachTumor induction on murine model bearing a 500 mm3 subcutaneous lesion. Increasing dose of gold nanoparticles at fixed initial concentration C0 = 0.3 mg/mL, infused into the tumor then exposition of the region of interest to NIR medical laser to assess the therapy. One or two intratumoral administration(s) were compared to surgery and control, that is no treatment, laser alone or nanoparticles alone.ResultsGold nanoparticles alone or the NIR laser alone did not induce the tumor regression. The combination of laser and nanoparticles called plasmonic nanophotothermal therapy induced apoptosis. Derma and hypoderm do not show any visible gold nanoparticles and demonstrated a good cicatrization process.ConclusionPlasmonic nanophotothermal therapy using two doses of gold nanoparticles was the only protocol that proved its efficacy on large lesions in 14 days, that is 500 mm3 on a murine model bearing human basal cell carcinoma.
Mapping as a collective and southern practice
Authors: Bhan Gautam 
Published: August 2024

AbstractThis reflective paper describes a relationship to mapping as a collective and southern practice. Using examples from the author's own involvement in collective map‐making practices based in New Delhi, the paper roots mapping in the context of southern urbanisms, taking examples of informal housing, work, and workplaces to debate the role of mapping vis‐à‐vis the desire for either more or less visibility. It then argues that mapping must reflect prevailing rationalities of governance and power, thinking about both why we make maps and who makes maps. Finally, it suggests that mapping as a process must extend from the making of a map to an active engagement in how it circulates and is read. The paper suggests the author's own experience with collective political formations as a possible institutional form that can hold such an approach to mapping.