bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatics Methods and Tools to Advance Clinical Care
Authors: Lecroq T. , Soualmia L. F. ,   Section Editors for the IMIA Yearbook Section on Bioinformatics and Translational Informatics
Published: August 2015

Summary
Objectives: To summarize excellent current research in the field of Bioinformatics and Translational Informatics with application in the health domain and clinical care.Method: We provide a synopsis of the articles selected for the IMIA Yearbook 2015, from which we attempt to derive a synthetic overview of current and future activities in the field. As last year, a first step of selection was performed by querying MEDLINE with a list of MeSH descriptors completed by a list of terms adapted to the section. Each section editor has evaluated separately the set of 1,594 articles and the evaluation results were merged for retaining 15 articles for peer-review.
Results: The selection and evaluation process of this Yearbook’s section on Bioinformatics and Translational Informatics yielded four excellent articles regarding data management and genome medicine that are mainly tool-based papers. In the first article, the authors present PPISURV a tool for uncovering the role of specific genes in cancer survival outcome. The second article describes the classifier PredictSNP which combines six performing tools for predicting disease-related mutations. In the third article, by presenting a high-coverage map of the human proteome using high resolution mass spectrometry, the authors highlight the need for using mass spectrometry to complement genome annotation. The fourth article is also related to patient survival and decision support. The authors present datamining methods of large-scale datasets of past transplants. The objective is to identify chances of survival.
Conclusions: The current research activities still attest the continuous convergence of Bioinformatics and Medical Informatics, with a focus this year on dedicated tools and methods to advance clinical care. Indeed, there is a need for powerful tools for managing and interpreting complex, large-scale genomic and biological datasets, but also a need for user-friendly tools developed for the clinicians in their daily practice. All the recent research and development efforts contribute to the challenge of impacting clinically the obtained results towards a personalized medicine.
Information Technology for Clinical, Translational and Comparative Effectiveness Research
Authors: Choquet R. , Daniel C. ,   Section Editors for the IMIA Yearbook Section on Clinical Research Informatics
Published: August 2015

Summary
Objectives: To select and summarize key constributions to current research and to select best papers published in 2014 in the field of Clinical Research Informatics (CRI).Method: A bibliographic search using a combination of MeSH and free terms search over PubMed on Clinical Research Informatics (CRI) was performed followed by a double-blind literature review.
Results: The review process yielded four papers, illustrating various aspects of current research efforts done in the area of CRI. The first paper exemplifies the process of developping a domain ontology for integrating structured, unstructured, and signal data into a coherent structure for patient care as well as clinical research. In the second paper, the authors analysed in five sites’ hospital information system environments in Germany the possibility of implementing a patient recruitment process and provided recommendations for the development of dedicated patient recruitment modules. The third paper describes the IMI EHR4CR project which developed an instance of a platform, providing communication, security and semantic interoperability services to the eleven participating hospitals and ten pharmaceutical companies located in seven European countries. The last paper describes the relation between health status severity and the availability of data in EHR systems. They demonstrate that it introduces a biasis in patient selection for clinical research.
Conclusions: Distributed research networks are growing in importance for clinical research and population health surveillance and current research demonstartes that different projects and initiatives could be well placed to deliver international scale solutions to enable the reuse of hospital EHR data to support clinical research studies. Selected articles demonstrate the potential of formal representation of multimodal and multi-level data in supporting data interoperability across clinical research and care domains. With the development of pragmatic research, designed with input from health systems and producing evidence that can be readily used to improve care, a key issue for “learning health care organizations” is to systematically assess the quality of their data.
Findings from the Clinical Information Systems Perspective
Authors: Ganslandt T. , Hackl W.O. ,   Section Editors for the IMIA Yearbook Section on Clinical Information Systems
Published: August 2015

Summary
Objective: To summarize recent research and to propose a selection of best papers published in 2014 in the field of Clinical Information Systems (CIS).Method: A query with search terms from the Medical Subject Headings (MeSH) catalog as well as additional free text search terms was designed to identify relevant publications in the field of clinical information systems from PubMed and Web of Science®. The retrieved articles were then categorized in a multi-pass review carried out separately by the section editors. The final selection of 15 candidate papers was then peer-reviewed by Yearbook editors and external reviewers. Based on the review results the four best papers were then selected at the best papers selection meeting with the IMIA Yearbook editorial board.
Results: The query was carried out in mid-January 2015, yielding a combined result set of 1525 articles which were published in 722 different journals. Among these articles two main thematic sections were identified: i) Interoperability from a syntactical and semantic point of view as well as from a long-term preservation and organizational/legal point of view and ii) secondary use of existing health data in all its shades. Here, patient safety was a major scope of application.
Conclusions: CIS have become mature over the last years. The focus has now moved beyond data acquisition for just supporting the local care workflows. Actual research efforts in the CIS domain comprise the breakdown of information silos, the reduction of barriers between different systems of different care providers and secondary use of accumulated health data for multiple purposes.
Knowledge Representation and Management. From Ontology to Annotation
Authors: Darmoni S.J. , Charlet J. ,   Section Editors for the IMIA Yearbook Section on Knowledge Representation and Management
Published: August 2015

Summary
Objective: To summarize the best papers in the field of Knowledge Representation and Management (KRM).
Methods: A comprehensive review of medical informatics literature was performed to select some of the most interesting papers of KRM published in 2014.
Results: Four articles were selected, two focused on annotation and information retrieval using an ontology. The two others focused mainly on ontologies, one dealing with the usage of a temporal ontology in order to analyze the content of narrative document, one describing a methodology for building multi-lingual ontologies.Conclusion: Semantic models began to show their efficiency, coupled with annotation tools.
Evaluating Autologous Lipofilling for Parry-Romberg Syndrome–Associated Defects: A Systematic Literature Review and Case Report
Authors: Rodby Katherine A. , Kaptein Yvonne E. , Roring James , Jacobs Ryan J. , Kang Vicky , Quinn Karina P. , Antony Anuja K. 
Published: August 2015

Background Parry-Romberg syndrome (PRS) is a rare craniofacial disease that causes progressive hemifacial atrophy of the soft tissue before spontaneously entering remission. Autologous fat grafting may provide a less invasive alternative, producing aesthetically pleasing results while avoiding the need for traditional microsurgical free flap coverage. Methods A systematic review of the literature was conducted. Inclusion and exclusion criteria were applied. The case report highlights the technique using two-dimensional and three-dimensional photography. Results Our review yielded 31 articles in addition to our case describing 147 cases of lipofilling to correct PRS soft-tissue defects. Patients underwent an average of 2.2 procedures, receiving on average 95 mL of grafted fat. Disease severity was classified into mild (41%), moderate (42%), and severe (17%) in the identified patients. Increasing disease severity correlated with an increasing number of procedures and fat-grafting volumes to achieve adequate aesthetic outcomes (mean, 1.5 and 38 mL; 2.3 and 81 mL; 3.7 and 129 mL, respectively). Reported benefits over flap-based reconstructions included reductions in cost (40%), operative time (50%), donor-site morbidity (52%), and rate of complications (33%). Aesthetic benefits cited included improved skin quality (65%), more natural contours (1%), and more natural facial expressions (10%). Conclusion Fat grafting for correction of PRS-associated soft-tissue defects is receiving heightened acceptance for its ability to restore natural facial contours. While additional fat-grafting procedures may be required with increased disease severity, autologous fat grafting may be a beneficial option as a sole modality to correct PRS-associated soft-tissue atrophy.
On-site veterinary medical evaluation and care of working dogs and horses at the 2012 Republican National Convention
Authors: Chatfield Jenifer A. , Dewell Reneé , Miranda Astrid J. , Wilcox Stefania , Vannieuwenhoven Ty J. 
Published: August 2015

Abstract
Objective—To describe on-site veterinary medical care for working dogs and horses deployed for the 2012 Republican National Convention (RNC) in Tampa, Fla, August 24 to 30, 2012.
Design—Retrospective case series.
Sample—130 dogs and 45 horses.
Procedures—Data collected included breed, age, history, task assignment, reason for evaluation, and physical examination findings. A patient encounter report was recorded each time an animal was seen by veterinary staff for a physical evaluation.
Results—46 of the 130 (35%) dogs and all 45 (100%) horses underwent at least 1 on-site veterinary evaluation, for a total of 478 patient encounters. The most common reason for an on-site veterinary evaluation was a wellness check (446 patient encounters). On the basis of veterinary recommendations, 1 dog and 4 horses were removed from continued service for the duration of the event. In addition, 1 dog and 1 horse were removed from active service for 12 to 24 hours but allowed to return to service for the duration of the event following a veterinary reevaluation.
Conclusions and Clinical Relevance—Results suggested that working dogs and horses deployed for large planned events face different health concerns, compared with concerns previously reported for animals deployed following disasters. Pre-event planning and training of handlers and riders may have helped reduce the number of health concerns, particularly health concerns related to high heat. (J Am Vet Med Assoc 2015;247:539–541)
Association of IL13R Alpha 1 + 1398A/G Polymorphism in a North Indian Population with Asthma: A Case-Control Study
Authors: Sinha Shweta , Singh Jagtar , Kumar Jindal Surinder , Birbian Niti 
Published: August 2015

Background Interleukin 13 (IL13) is directly involved in the secretion of total serum immunoglobulin E (IgE), which plays a major role in the asthma pathogenesis. Objective One of the polymorphic receptor of IL13 is IL13Rα1, which after binding to IL13, initiates signal transduction that results in mucin secretion, airway hyperreactivity, fibrosis, and chitinase up-regulation, which increases asthma risk. Methods In the present study, the role of IL13Rα1 + 1398A/G gene polymorphisms in asthma was detected with a total of 964 individuals, including 483 healthy controls and 481 asthma patients from a North Indian population using polymerase chain reaction-restriction fragment length polymorphism method. Results Statistical analysis revealed that the mutant allele (G) is predominant in asthma patients (42.7%) than the controls (38.2%), which shows an increased risk toward asthma with odds ratio = 1.21, 95% confidence interval (1.00 −1.45), χ2 = 4.10 and p = 0.043. Furthermore, the phenotypic characteristics also reveal a significant association with the disease (p < 0.05). Conclusions This is the first study conducted in India and + 1398A/G polymorphism in noncoding region of IL13Rα1 confer risk toward asthma in the studied population.
Are CMS G-Code Functional Limitation Severity Modifiers Responsive to Change Across an Episode of Outpatient Rehabilitation?
Authors: Jette Diane U. , Stilphen Mary , Ranganathan Vinoth K. , Jette Alan M. 
Published: August 2015

BackgroundThe Centers for Medicare & Medicaid Services has mandated rehabilitation professionals to document patients' impairment levels. There is no evidence of responsiveness to change of functional limitation severity modifier codes.ObjectiveThe purpose of this study was to assess the validity of G-code functional limitation severity modifier codes in determining change in function.DesignThis was a retrospective observational study.MethodsPatients completed the Activity Measure for Post-Acute Care (AM-PAC) and were assigned G-codes, with severity modifiers based on AM-PAC scores at initial and follow-up visits. Patients were classified as having AM-PAC scores in the upper or lower range for each severity modifier, and sensitivity, specificity, and positive and negative predictive values for change in severity modifier level and odds of changing by one severity modifier level using a change in AM-PAC score of at least 1 minimal detectable change at the 95% confidence interval (MDC95) as the standard were determined.ResultsSensitivity and specificity of change in severity modifier in determining change in function were dependent on patients' initial AM-PAC scores. Improvement in severity modifier level was 2.2 to 4.5 times more likely with scores at the higher end of the range within a severity modifier level than with scores in the lower end of the range. Decline in severity modifier level was 2.7 to 4.8 times more likely with scores at the lower end of the range within a severity modifier than with scores in the higher end of the range.LimitationsData were from one health care system, and most patients had orthopedic conditions. The MDC95 for AM-PAC tool may not be the best standard for defining functional change.ConclusionsThe G-code functional limitation severity modifier system may not be valid for determining change in function and is not recommended for determining if patients have changed over the course of outpatient therapy.
Krapp at the Hawk’s Well: Beckett, Yeats, and Joyce
Authors: Lawley Paul 
Published: August 2015

abstract: Starting from the recognized problematic of choice as dramatic determinant in Krapp’s Last Tape (1958), this study scrutinizes the thematic affinity and resemblances in figuration between the Beckett play and another piece about an old man reviewing his life, W.B. Yeats’s Noh-inspired At the Hawk’s Well (1917), which Beckett is known to have admired. In light of the acknowledged (though disputed) autobiographical significance of Krapp’s life-changing “vision,” the linkage between this play and Beckett’s relation to his mentor and greatest influence, James Joyce, is considered. It is argued that the Yeats play acts as a thematic model and artistic buffer that provides vital imaginative space for Beckett in his creative agon with Joyce as precursor.
Unsettling Gertrude Stein: On the Citability of Baroque Gesture inFour Saints in Three Acts
Authors: Cermatori Joseph 
Published: August 2015

abstract:This article focuses on Gertrude Stein’s 1927 opera Four Saints in Three Acts, which takes a pair of baroque saints for its protagonists and which debuted in a 1934 production replete with deliberate citations of baroque stage design, gesture, and visual art – details that have gone almost entirely unacknowledged in the past several decades’ scholarship on Stein. It recovers these forgotten production details by juxtaposing a reading of Stein’s text and performance theories alongside Walter Benjamin’s vision of baroque theatre as articulated in The Origin of German Trauerspiel. Interpreting Stein’s methods within the frame of baroque theatrical allegory, it suggests Stein’s situation within a larger tradition of baroque modernism. It argues that Stein found, within the concept of the baroque, a productive means of challenging norms of representation across a wide array of registers – linguistic, aesthetic, sexual, racial, and historiographic.
The Field ofModern Drama, or Arcadia
Authors: Gobert R. Darren 
Published: August 2015

abstract:This article describes the journal’s field of enquiry as its new editor sees it. Considering details drawn from the rehearsal typescripts and published scripts of Tom Stoppard’s Arcadia alongside details drawn from four of the play’s major productions (1993, 1995, 2009, 2011), the article argues that this archive helps us to understand the productive instability of plays in performance and to understand how critics might read them. Tracing its argument alongside those of central proponents of performance theory – e.g., Peggy Phelan, Joseph Roach, Rebecca Schneider – the article concludes that, like the mythical Arcadia, the field of modern drama is nowhere fixed.
Elizabeth Maddock Dillon, New World Drama: The Performative Commons in the Atlantic World, 1649–1849
Authors: Shaffer Jason 
Published: August 2015

ABSTRACT: Dillon traces the evolution of popular sovereignty as represented through theatrical depictions of race and economic power between the late-seventeenth and mid-nineteenth centuries in the British Atlantic. The work is impressively detailed and ably synthesizes much of the current scholarship in Atlantic performance history with the author’s own ideas.
Learning from the Dramaturg: Suzan-Lori Parks’s The America Play in the Literature Classroom
Authors: Bean Heidi R. 
Published: August 2015

abstract: This essay offers the strategy of “dramaturgical arousal” as a pedagogical model for engaging with drama in the literature classroom. Using Mark Bly’s ground-breaking dramaturgical work on Suzan-Lori Parks’s The America Play, including the theatre program he produced for its Yale Repertory premiere, as well as the play’s co-collaborative mobilization of text and performance, “Learning from the Dramaturg” offers a new way of rethinking the often fraught divide between text and theatre. Just as Parks’s jazz poetics performatively riff on the historical record, so too does Bly’s work co-performatively riff on the play, producing collaborative engagements that are more generative than evaluative. Fostering greater critical awareness of the ways in which the differing codes of textuality and performance produce their audiences, these collaborations model fresh encounters that fruitfully blur the distinctions between drama/literature and performance/theatre.
Sensitivity and specificity of intrathecal fluorescein and white light excitation for detecting intraoperative cerebrospinal fluid leak in endoscopic skull base surgery: a prospective study
Authors: Raza Shaan M. , Banu Matei A. , Donaldson Angela , Patel Kunal S. , Anand Vijay K. , Schwartz Theodore H. 
Published: August 2015

OBJECT
The intraoperative detection of CSF leaks during endonasal endoscopic skull base surgery is critical to preventing postoperative CSF leaks. Intrathecal fluorescein (ITF) has been used at varying doses to aid in the detection of intraoperative CSF leaks. However, the sensitivity and specificity of ITF at certain dosages is unknown.

METHODS
A prospective database of all endoscopic endonasal procedures was reviewed. All patients received 25 mg ITF diluted in 10 ml CSF and were pretreated with dexamethasone and Benadryl. Immediately after surgery, the operating surgeon prospectively noted if there was an intraoperative CSF leak and fluorescein was identified. The sensitivity, specificity, and positive and negative predictive power of ITF for detecting intraoperative CSF leak were calculated. Factors correlating with postoperative CSF leak were determined.

RESULTS
Of 419 patients, 35.8% of patients did not show a CSF leak. Fluorescein-tinted CSF (true positive) was noted in 59.7% of patients and 0 false positives were encountered. CSF without fluorescein staining (false negative) was noted in 4.5% of patients. The sensitivity and specificity of ITF were 92.9% and 100%, respectively. The negative and positive predictive values were 88.8% and 100%, respectively. Postoperative CSF leaks only occurred in true positives at a rate of 2.8%.

CONCLUSIONS
ITF is extremely specific and very sensitive for detecting intraoperative CSF leaks. Although false negatives can occur, these patients do not appear to be at risk for postoperative CSF leak. The use of ITF may help surgeons prevent postoperative CSF leaks by intraoperatively detecting and confirming a watertight repair.
Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus
Authors: Khoo Hui Ming , Kishima Haruhiko , Tani Naoki , Oshino Satoru , Maruo Tomoyuki , Hosomi Koichi , Yanagisawa Takufumi , Kazui Hiroaki , Watanabe Yoshiyuki , Shimokawa Toshio , Aso Toshihiko , Kawaguchi Atsushi , Yamashita Fumio , Saitoh Youichi , Yoshimine Toshiki 
Published: August 2015

OBJECT
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder characterized by gait disturbance, cognitive impairment, and incontinence. It is unclear whether the pathophysiology of iNPH is associated with alterations in the default mode network (DMN). The authors investigated alterations in the DMN of patients with iNPH and sought to determine whether a relationship exists between the resting-state functional connectivity of the DMN and a patient’s clinical symptoms.

METHODS
Resting-state functional MRI (rs-fMRI) was performed in 16 preoperative patients with iNPH and 15 neurologically healthy control subjects of a similar age. Independent component and dual-regression analyses were used to quantify DMN connectivity. The patients’ clinical symptoms were rated according to the iNPH grading scale (iNPHGS). Each of their specific clinical symptoms were rated according to the cognitive, gait, and urinary continence domains of iNPHGS, and neurocognitive status was assessed using the Mini-Mental State Examination, Frontal Assessment Battery (FAB), and Trail Making Test Part A. The strength of DMN connectivity was compared between patients and controls, and the correlation between DMN connectivity and iNPHGS was examined using both region of interest (ROI)-based analysis and voxel-based analysis. The correlation between DMN connectivity and each of the specific clinical symptoms, as well as neurocognitive status, was examined using voxel-based analysis.

RESULTS
Both ROI-based and voxel-based analyses revealed reduced DMN connectivity in patients with iNPH. ROI-based analysis showed increased DMN connectivity with worsening clinical symptoms of iNPH. Consistently, voxel-based analyses revealed that DMN connectivity correlated positively with the iNPHGS score, as well as the cognitive and urinary continence domain scores, and negatively with the FAB score. The significant peak in correlation in each case was localized to the precuneus.

CONCLUSIONS
This is the first study to establish alterations in the DMN of patients with iNPH. DMN connectivity may be a useful indicator of the severity of clinical symptoms in patients with iNPH.