bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of a free-weight-based resistance training intervention on pain, squat biomechanics and MRI-defined lumbar fat infiltration and functional cross-sectional area in those with chronic low back
Authors: Welch Neil , Moran Kieran , Antony Joseph , Richter Chris , Marshall Brendan , Coyle Joe , Falvey Eanna , Franklyn-Miller Andrew 
Published: November 2015

BackgroundLow back pain is one of the most prevalent musculoskeletal conditions in the world. Many exercise treatment options exist but few interventions have utilised free-weight resistance training. To investigate the effects of a free-weight-based resistance training intervention on pain and lumbar fat infiltration in those with chronic low back pain.MethodsThirty participants entered the study, 11 females (age=39.6±12.4 years, height=164 cm±5.3 cm, body mass=70.9±8.2 kg,) and 19 males (age=39.7±9.7 years, height=179±5.9 cm, body mass=86.6±15.9 kg). A 16-week, progressive, free-weight-based resistance training intervention was used. Participants completed three training sessions per week. Participants completed a Visual Analogue Pain Scale, Oswestry Disability Index and Euro-Qol V2 quality of life measure at baseline and every 4 weeks throughout the study. Three-dimensional kinematic and kinetic measures were used for biomechanical analysis of a bodyweight squat movement. Maximum strength was measured using an isometric mid-thigh pull, and lumbar paraspinal endurance was measured using a Biering-Sorensen test. Lumbar paraspinal fat infiltration was measured preintervention and postintervention using MRIs.ResultsPostintervention pain, disability and quality of life were all significantly improved. In addition, there was a significant reduction in fat infiltration at the L3L4 and L4L5 levels and increase in lumbar extension time to exhaustion of 18%.ConclusionsA free-weight-based resistance training intervention can be successfully utilised to improve pain, disability and quality of life in those with low back pain.
Diamond: immunohistochemistry versus sequencing inEGFRanalysis of lung adenocarcinomas
Authors: Ragazzi Moira , Tamagnini Ione , Bisagni Alessandra , Cavazza Alberto , Pagano Maria , Baldi Licia , Boni Corrado , Cantile Flavia , Barbieri Fausto , Nicoli Davide , Sartori Giuliana , de Biase Dario , Gardini Giorgio , Rossi Giulio 
Published: November 2015

AimsIdentification of epidermal growth factor receptor (EGFR) mutations in lung adenocarcinomas is the single most important predictor of clinical response and outcome using EGFR tyrosine kinase inhibitors (TKIs).EGFRE746-A750del and L858R mutations are the most common gene alterations, also predicting the best clinical response to TKIs. We evaluated the accuracy of EGFR mutation-specific antibodies in a large cohort of lung adenocarcinomas, with different molecular settings and types of tissue samples.Methods300 lung adenocarcinomas diagnosed on cytology (48 cell blocks), biopsy (157 cases) and surgical resections (95 cases) were selected. All cases were investigated for EGFR by sequencing and two mutation-specific antibodies (clone 6B6 for E746-A750del; clone 43B2 for L858R) were tested using an automated immunostainer. Discordant results were investigated by next-generation sequencing (NGS).ResultsOverall sensitivity and specificity of mutant-specific antibodies were 58.6% and 98.0%, respectively, and they increased up to 84% and 100% if only tumours harbouring E746-A750del were considered. In 13 discordant cases, NGS confirmed immunohistochemistry results in eight samples.ConclusionsTheEGFRmutation-specific antibodies have a fair/good sensitivity and good/high specificity in identifying classic mutations, but they cannot replace molecular tests. The antibodies work equally well on biopsies and cell blocks, possibly permitting a rapid screening in cases with poor material.
GPUSPH: a Smoothed Particle Hydrodynamics model for the thermal and rheological evolution of lava flows
Authors: Bilotta Giuseppe , Hérault Alexis , Cappello Annalisa , Ganci Gaetana , Del Negro Ciro 
Published: November 2015

Abstract
GPUSPH is a fully three-dimensional model for the simulation of the thermal and rheological evolution of lava flows that relies on the Smoothed Particle Hydrodynamics (SPH) numerical method. Thanks to the Lagrangian, meshless nature of SPH, the model incorporates a more complete physical description of the emplacement process and rheology of lava that considers the free surface, the irregular boundaries represented by the topography, the solidification fronts and the non-Newtonian rheology with temperature-dependent parameters. GPUSPH follows the very general Herschel–Bulkley rheological model, which encompasses Newtonian, power-law and Bingham flow behaviours, with both constant and temperature-dependent parameters, and can thus be used to explore in detail the impact of rheology on the behaviour of lava flows and on their emplacement. To illustrate this possibility, we present some preliminary applications of the model for studying the rheology of lava flows with different constitutive relationships and thermal regimes using the real topography of the Mt Etna volcano.
Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Authors: Picaud Sarah , Fedorov Oleg , Thanasopoulou Angeliki , Leonards Katharina , Jones Katherine , Meier Julia , Olzscha Heidi , Monteiro Octovia , Martin Sarah , Philpott Martin , Tumber Anthony , Filippakopoulos Panagis , Yapp Clarence , Wells Christopher , Che Ka Hing , Bannister Andrew , Robson Samuel , Kumar Umesh , Parr Nigel , Lee Kevin , Lugo Dave , Jeffrey Philip , Taylor Simon , Vecellio Matteo L. , Bountra Chas , Brennan Paul E. , O'Mahony Alison , Velichko Sharlene , Müller Susanne , Hay Duncan , Daniels Danette L. , Urh Marjeta , La Thangue Nicholas B. , Kouzarides Tony , Prinjha Rab , Schwaller Jürg , Knapp Stefan 
Published: November 2015

Abstract
The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate inhibitors of CBP/p300 are of clinical value. We developed a specific and potent acetyl-lysine competitive protein–protein interaction inhibitor, I-CBP112, that targets the CBP/p300 bromodomains. Exposure of human and mouse leukemic cell lines to I-CBP112 resulted in substantially impaired colony formation and induced cellular differentiation without significant cytotoxicity. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9+ acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin. Collectively, we report the development and preclinical evaluation of a novel, potent inhibitor targeting CBP/p300 bromodomains that impairs aberrant self-renewal of leukemic cells. The synergistic effects of I-CBP112 and current standard therapy (doxorubicin) as well as emerging treatment strategies (BET inhibition) provide new opportunities for combinatorial treatment of leukemia and potentially other cancers. Cancer Res; 75(23); 5106–19. ©2015 AACR.
Hemodynamic, Functional, and Clinical Responses to Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension of Different Causes
Authors: Chen Shao-Liang , Zhang Hang , Xie Du-Jiang , Zhang Juan , Zhou Ling , Rothman Alexander M.K. , Stone Gregg W. 
Published: November 2015

Background—
The mechanisms underlying pulmonary arterial hypertension (PAH) are multifactorial. The efficacy of pulmonary artery denervation (PADN) for idiopathic PAH treatment has been evaluated. This study aimed to analyze the hemodynamic, functional, and clinical responses to PADN in patients with PAH of different causes.

Methods and Results—
Between April 2012 and April 2014, 66 consecutive patients with a resting mean pulmonary arterial pressure ≥25 mm Hg treated with PADN were prospectively followed up. Target drugs were discontinued after the PADN procedure. Hemodynamic response and 6-minute walk distance were repeatedly measured within the 1 year post PADN follow-up. The clinical end point was the occurrence of PAH-related events at the 1-year follow-up. There were no PADN-related complications. Hemodynamic success (defined as the reduction in mean pulmonary arterial pressure by a minimal 10% post PADN) was achieved in 94% of all patients, with a mean absolute reduction in systolic pulmonary arterial pressure and mean pulmonary arterial pressure within 24 hours of −10 mm Hg and −7 mm Hg, respectively. The average increment in 6-minute walk distance after PADN was 94 m. Worse PAH-related events occurred in 10 patients (15%), mostly driven by the worsening of PAH (12%). There were 8 (12%) all-cause deaths, with 6 (9%) PAH-related deaths.

Conclusions—
PADN was safe and feasible for the treatment of PAH. The PADN procedure was associated with significant improvements in hemodynamic function, exercise capacity, and cardiac function and with less frequent PAH-related events and death at 1 year after PADN treatment. Further randomized studies are required to confirm the efficacy of PADN for PAH.

Clinical Trial Registration—

URL:
http://www.chictr.trc.com.cn
. Unique identifier: chiCTR-ONC-12002085.
Varenicline for Smoking Cessation in Hospitalized Patients With Acute Coronary Syndrome
Authors: Eisenberg Mark J. , Windle Sarah B. , Roy Nathalie , Old Wayne , Grondin François R. , Bata Iqbal , Iskander Ayman , Lauzon Claude , Srivastava Nalin , Clarke Adam , Cassavar Daniel , Dion Danielle , Haught Herbert , Mehta Shamir R. , Baril Jean-François , Lambert Charles , Madan Mina , Abramson Beth L. , Dehghani Payam 
Published: November 2015

Background—
Less than one-third of smokers hospitalized with an acute coronary syndrome (ACS) remain abstinent following discharge. We assessed whether varenicline, begun in-hospital, is efficacious for smoking cessation following ACS.

Methods and Results—

We conducted a multi-center, double-blind, randomized, placebo-controlled trial in which smokers hospitalized with an ACS were randomized to varenicline or placebo for 12 weeks. All patients received low-intensity counseling. The primary end point was point-prevalence smoking abstinence assessed at 24 weeks by 7-day recall and biochemical validation using expired carbon monoxide. A total of 302 patients were randomized (mean age 55±9 years; 75% male; 56% ST-segment elevation myocardial infarction; 38% non-ST-segment elevation myocardial infarction; 6% unstable angina). Patients smoked a mean of 21±11 cigarettes/d at the time of hospitalization and had been smoking for a mean of 36±12 years. At 24 weeks, patients randomized to varenicline had significantly higher rates of smoking abstinence and reduction than patients randomized to placebo. Point-prevalence abstinence rates were 47.3% in the varenicline group and 32.5% in the placebo group (
P
=0.012; number needed to treat=6.8). Continuous abstinence rates were 35.8% and 25.8%, respectively (
P
=0.081; number needed to treat=10.0), and rates of reduction ≥50% in daily cigarette consumption were 67.4% and 55.6%, respectively (
P
=0.05; number needed to treat=8.5). Adverse event rates within 30 days of study drug discontinuation were similar between groups (serious adverse events: varenicline 11.9%, placebo 11.3%; major adverse cardiovascular events: varenicline 4.0%, placebo 4.6%).

Conclusions—
Varenicline, initiated in-hospital following ACS, is efficacious for smoking cessation. Future studies are needed to establish safety in these patients.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00794573.
Association of Left Ventricular Hypertrophy With a Faster Rate of Renal Function Decline in Elderly Patients With Non‐End‐Stage Renal Disease
Authors: Shi Hong‐tao , Wang Xiao‐jing , Li Jun , Song Gui‐fang , Huang Zhe‐yong , Guo Xiang‐yu , Guo Jun‐jie , Lv Zhi‐yang , Li Hong‐wei , Ge Jun‐bo , Cui Jie , Qi Guan‐ming 
Published: November 2015

Background

Several studies have indicated that chronic kidney disease is independently associated with the presence of left ventricular hypertrophy (
LVH
). However, little clinical data are currently available regarding the detailed correlation between
LVH
and renal function in elderly patients with non–end‐stage renal disease.

Methods and Results

A total of 300 in‐ and outpatients (more than 60 years of age, non‐end‐stage renal disease), 251 with
LVH
and 49 without
LVH
, seen at Beijing Friendship Hospital from January 2000 to December 2010 were included in this retrospective study. One observation period of 12 months was used to detect rapid kidney function decline. The evaluations of cardiac structure and function were performed via echocardiography. The multivariable logistic analysis showed patients with
LVH
had a much higher risk of rapid kidney function decline than those without
LVH
. Additionally, the baseline left ventricular mass index was 140 (125–160) g/m
2
in the non–chronic kidney disease group, 152 (130–175) g/m
2
in the mild chronic kidney disease group (estimated glomerular filtration rate (eGFR)≥60 ml/min/1.73 m
2
), and 153 (133–183) g/m
2
in the severe chronic kidney disease group (eGFR<60 ml/min/1.73 m
2
), with a significant difference (
P
=0.009).

Conclusions

Our data demonstrate that a high rate of renal function decline contributes to pathological
LVH
in non–end‐stage renal disease elderly patients and that
LVH
is positively associated with renal function decline followed by an increased risk of rapid kidney function decline.
A comparative discourse study of simulated clinical roleplays in two assessment contexts: Validating a specific-purpose language test
Authors: Woodward-Kron Robyn , Elder Catherine 
Published: November 2015

The aim of this paper is to investigate from a discourse analytic perspective task authenticity in the speaking component of the Occupational English Test (OET), an English language screening test for clinicians designed to reflect the language demands of health professional–patient communication. The study compares the OET speaking sub-test roleplay performances of 12 doctors who were successful OET candidates with practice Objective Structured Clinical Examination (OSCE) roleplay performances of 12 international medical graduates (IMGs) preparing for the Australian Medical Council clinical examination. The premise for the comparison is that the OSCE roleplays can represent communication practices that are valued within the medical profession; therefore a finding of similarity in the discourse structure across the OET and the OSCE roleplays could be taken as supporting the validity of the OET as a tool for eliciting relevant communication skills in the medical profession. The study draws on genre theory as developed in Systemic Functional Linguistics (SFL) in order to compare the roleplay discourse structure and the linguistic realizations of the two tasks. In particular, it examines the role relationships of the participants (i.e. the tenor of the discourse), and the ways in which content is represented (i.e. the field of the discourse) by roleplay participants. The findings reveal some key similarities but also important differences. Although both tests inevitably fall short in terms of authentic representation of real world interactions, the findings suggest that the OET task, for a range of reasons including time allowances, training of test interlocutors, and the limits of contextual information provided to candidates, constrains candidate topic exploration and treatment negotiation, compared to the OSCE format. The paper concludes with proposals for mitigating these limitations in the interests of enhancing the OET’s capacity to elicit more professionally relevant language and communication skills.
Varicose veins—Who should be referred?
Authors: Onida Sarah , Davies Alun H , Franklin Ian 
Published: November 2015

Varicose veins are a common, progressive condition in the UK, with significant negative effects on patients’ quality of life. Despite their prevalence, access to secondary care for the assessment and treatment of varicose veins can be variable throughout the country. The National Institute of Health and Care Excellence guidelines developed in 2013 provide evidence-based guidance on the referral, assessment, and management of the patient with venous disease. In this article, we review the development of the guidelines for the management of varicose veins over the last 15 years, highlighting the latest changes in referral criteria.
Management of reticular veins and telangiectases
Authors: Smith Philip Coleridge 
Published: November 2015

Aim To review the literature related to the management of reticular varices and telangiectases of the lower limbs to provide guidance on the treatment of these veins. Findings Very few randomised clinical trials are available in this field. A European Guideline has been published on the treatment of reticular varices and telangiectases, which is largely based on the opinion of experts. Older accounts written by individual phlebologists contain extensive advice from their own practice, which is valuable in identifying effective methods of sclerotherapy. All accounts indicate that a history should be taken combined with a clinical and ultrasound examination to establish the full extent of the venous disease. Sclerotherapy is commenced by injecting the larger veins first of all, usually the reticular varices. Later in the same session or in subsequent sessions, telangiectases can be treated by direct injection. Following treatment, the application of class 2 compression stockings for a period of up to three weeks is beneficial but not used universally by all phlebologists. Further sessions can follow at intervals of 2–8 weeks in which small residual veins are treated. Resistant veins can be managed by ultrasound-guided injection of underlying perforating veins and varices. Other treatments including RF diathermy and laser ablation of telangiectases have very limited efficacy in this condition. Conclusions Sclerotherapy, when used with the correct technique, is the most effective method for the management of reticular varices and telangiectases.
Human and experimental toxicology of orellanine
Authors: Dinis-Oliveira Ricardo Jorge , Soares Mariana , Rocha-Pereira Carolina , Carvalho Félix 
Published: November 2015

Orellanine is a nephrotoxic toxin produced by some mushroom species of the Cortinarius genus, typically found in Europe and North America. The nephrotoxicity of Cortinarius orellanus is well known and was first recognized in the 1950s when this mushroom was identified as the cause of a mass poisoning in Poland. Typically, onset of symptoms is delayed for 1–2 weeks after ingestion. Some patients suffer mild gastrointestinal discomfort in the latency period before developing signs of renal impairment due to severe interstitial nephritis, acute focal tubular damage, and interstitial fibrosis. There is no specific antidote to orellanine poisoning. The mainstay of treatment is the prevention of secondary complications of kidney failure, adequate dialysis and, in the case of incomplete recovery, management of chronic renal insufficiency. In this work, we aim to review about Cortinarius species, including epidemiological studies, chemical structure, toxicokinetics, toxic doses, mechanisms of toxicity, diagnosis, prognosis, and treatment options.
A telegeriatric service in a small rural hospital: A case study and cost analysis
Authors: Versleijen Marloes , Martin-Khan Melinda G , Whitty Jennifer A , Smith Anthony C , Gray Leonard C 
Published: November 2015

Introduction Small hospitals in rural areas usually have an insufficient caseload of frail old people to justify the regular presence of a geriatrician. This study examined the costs of providing a telegeriatric service by videoconference in a rural hospital, compared to the costs of a visiting geriatrician that travels to undertake in-person consultations. Methods A cost analysis was undertaken to compare the costs of the telegeriatric service model with the costs of a visiting geriatrician service model. A recently established telegeriatric service at Warwick Hospital was used as a case study. Results In the base case model (assuming four patients per round and a round-trip travel distance of 312 kilometres), an estimated AUD$131 per patient consultation can be saved in favour of the telegeriatric service model. Key drivers of costs are the number of patients per round and the travel distance and time in the visiting geriatrician model. At a workload of four patients per round, it is less expensive to conduct a telegeriatric service than a visiting geriatrician service when the round-trip travel time exceeds 76 minutes. Discussion Even under quite conservative assumptions, a telegeriatric service offers an economically feasible approach to the delivery of specialist geriatric assessment in rural and remote settings.
Gender and Diversity in India
Authors: Ghosh Rajashi 
Published: November 2015

The Problem Diversity and gender are contested topics in India. Although diversity means many things to many people, the meanings associated with diversity and the approaches to diversity management in India influence and are influenced by power structures and sociocultural values. Similarly, the intersection of gender with other diversity factors, such as caste, religion, or age, makes gender inequality a complex challenge in India. In the wake of globalization and changing nature of work, human resource development (HRD) professionals are faced with an ambitious task of unraveling these complexities and identifying effective ways to manage diversity and promote gender equality in organizations and in the Indian society at large. The Solution This issue is a significant step forward toward advancing gender and diversity theories and conceptual models and frameworks within the underlying sociocultural assumptions and beliefs in India. In doing so, the articles in this issue guide HRD professionals to undertake a multipronged (i.e., organizational, societal, national) and a critical inquiry into the challenges posed by gender and diversity in India. The Stakeholders HRD scholars and practitioners interested in research on global or international HRD would benefit from the theoretical and empirical work presented in this issue. Particularly, those who are interested in understanding the complex challenges posed by gender and diversity in India would learn how HRD models and theories apply to the unique sociocultural context of India. Also, the scholars from other social science disciplines who work on topics of diversity and gender would get a glimpse of how these topics manifest in an emerging economy like India.
Structural basis for collagen recognition by the immune receptor OSCAR
Authors: Zhou Long , Hinerman Jennifer M. , Blaszczyk Michal , Miller Jeanette L. C. , Conrady Deborah G. , Barrow Alexander D. , Chirgadze Dimitri Y. , Bihan Dominique , Farndale Richard W. , Herr Andrew B. 
Published: November 2015

Key Points
OSCAR has 2 immunoglobulin-like domains with an obtuse interdomain angle, differing from other members of the leukocyte receptor cluster. Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI and LAIR-1.