bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Selective Pyrone Functionalization: Reductive Alkylation of Triacetic Acid Lactone.
Authors: Kraus George A. , Basemann Kevin , Guney Tezcan 
Published: September 2015

AbstractThe reductive alkylation of triacetic acid lactone with aldehydes allows the synthesis of 3‐alkylated derivatives including naturally accruing compound (VI).
ChemInform Abstract: Formation of Fused Aromatic Architectures via an Oxidative Dearomatization—Radical Cyclization Rearomatization Approach.
Authors: Vitaku Edon , Njardarson Jon T. 
Published: September 2015

AbstractChromane and dihydrobenzofurane products are prepared from catechol derivatives via initial dearomatization followed by low temperature radical cyclization.
ChemInform Abstract: One‐Pot Synthesis of a Natural Product Inspired Pyrrolocoumarine Compound Collection by Means of an Intramolecular 1,3‐Dipolar Cycloaddition as Key Step.
Authors: Vidadala Srinivasa Rao , Waldmann Herbert 
Published: September 2015

AbstractThis convenient one‐pot synthesis includes N‐deprotection of substrate (I) and (IV) followed by azomethine ylide formation with an aldehyde, intramolecular 1,3‐dipolar cycloaddition, and final oxidative aromatization.
ChemInform Abstract: PMA‐SiO2 Catalyzed Synthesis of Indolo[2,3‐c]quinolines as Potent Anticancer Agents.
Authors: Srihari P. , Padmabhavani B. , Ramesh S. , Bharath Kumar Y. , Singh Ashita , Ummanni R. 
Published: September 2015

AbstractSome of the title compounds (III), synthesized via a Pictet—Spengler reaction, are found to be cytotoxic against prostate, lung, breast, and cervical cancer cell lines.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed [2 + 3] Cyclocondensation of α‐Chloroaldehydes with Azomethine Imines.
Authors: Gao Zhong‐Hua , Chen Xiang‐Yu , Cheng Jin‐Tang , Liao Wei‐Lin , Ye Song 
Published: September 2015

AbstractTitle reaction provides corresponding 3‐aroyl‐1‐alkyl/aryltetrahydropyrazolo[5,1‐a]isoquinolin‐2‐ones (III) and (V) in good to high yields, moderate dia‐ and excellent enantioselectivities.
ChemInform Abstract: A Highly‐Efficient Palladium‐Catalyzed Aminocarbonylation/SNAr Approach to Dibenzoxazepinones.
Authors: Shen Chaoren , Neumann Helfried , Wu Xiao‐Feng 
Published: September 2015

AbstractVarious 2‐aminophenols and 2‐bromofluorobenzenes are used as substrates for the convenient one‐pot synthesis of a wide range of dibenzoxazepinones by a palladium‐catalyzed aminocarbonylation/aromatic nucleophilic substitution sequence.
ChemInform Abstract: Facile Net Cycloaddition Approach to Optically Active 1,5‐Benzothiazepines.
Authors: Fukata Yukihiro , Asano Keisuke , Matsubara Seijiro 
Published: September 2015

AbstractThe first example of a highly enantio‐ and regioselective net [4 + 3] cycloaddition approach towards 1,5‐benzothiazepines is presented.
ChemInform Abstract: Late‐Stage Functionalization of 1,2‐Dihydro‐1,2‐azaborines via Regioselective Iridium‐Catalyzed C—H Borylation: The Development of a New N,N‐Bidentate Ligand Scaffold.
Authors: Baggett Andrew W. , Vasiliu Monica , Li Bo , Dixon David A. , Liu Shih‐Yuan 
Published: September 2015

AbstractFor the first time, an Ir‐catalyzed regioselective C—H borylation of monocyclic 1,2‐azaborines is described.
ChemInform Abstract: Speradines B—D, Oxygenated Cyclopiazonic Acid Alkaloids from the Sponge‐Derived Fungus Aspergillus flavus MXH‐X104.
Authors: Ma Xinhua , Peng Jixing , Wu Guangwei , Zhu Tianjiao , Li Guoqiang , Gu Qianqun , Li Dehai 
Published: September 2015

Abstractisolation, structure elucidation and bioassay screening
HPV infection and p16 promoter methylation as predictors of ASC‐US/LSIL progression
Authors: Lee Hee , Lee Eun‐Ju 
Published: September 2015

BACKGROUNDAlthough patients found to have atypical squamous cells of undetermined significance (ASC‐US) and low‐grade squamous intraepithelial lesions (LSILs) on Papanicolaou (Pap) testing are treated conservatively, 5.2% to 18.8% of them progress to high‐grade squamous intraepithelial lesions (HSILs). The objective of the current study was to identify predictors of progression to HSIL and determine what percentage of ASC‐US/LSIL cases harbor cervical intraepithelial neoplasia of grade 2 or higher.METHODSThe current study included 381 consecutive cases with ASC‐US/LSIL. After the exclusion of 87 cases because of a history of dysplasia or loss to follow‐up, 165 cases with follow‐up cytology were used to analyze predictive factors of progression to HSIL, and 129 cases that underwent immediate tissue biopsy were subjected to correlation analysis between cytology and histology. Disease regression was defined as a reversion to normal or benign cellular changes, disease persistence as maintenance at ASC‐US/LSIL, and disease progression as progression to HSIL. Data regarding clinical parameters were obtained from medical records. Methylation‐specific polymerase chain reaction was performed using cytology samples to evaluate methylation of the p16 promoter.RESULTSOf 165 cases, 131 (79.4%) regressed, 23 (13.9%) were persistent, and 11 cases (6.7%) progressed. Human papillomavirus infection was more common in women with disease progression than in those with disease regression or persistence (P = .033). Promoter methylation of p16 in the cytology sample was more common in cases that progressed (5 of 6 cases) than in cases that regressed (0 of 8 cases). Twenty‐three of 129 cases (17.8%) were found to harbor cervical intraepithelial neoplasia of grade 2 or higher on immediate tissue biopsy.CONCLUSIONSHuman papillomavirus infection and p16 promoter methylation might be valuable surrogate markers of disease progression from ASC‐US/LSIL to HSIL. Cancer (Cancer Cytopathol) 2016;124:58–65. © 2015 American Cancer Society.
Amorphous Aggregation of Amyloid Beta 1‐40 Peptide in Confined Space
Authors: Foschi Giulia , Albonetti Cristiano , Liscio Fabiola , Milita Silvia , Greco Pierpaolo , Biscarini Fabio 
Published: September 2015

AbstractThe amorphous aggregation of Aβ1‐40 peptide is addressed by using micromolding in capillaries. Both the morphology and the size of the aggregates are modulated by changing the contact angle of the sub‐micrometric channel walls. Upon decreasing the hydrophilicity of the channels, the aggregates change their morphology from small aligned drops to discontinuous lines, thereby keeping their amorphous structure. Aβ1‐40 fibrils are observed at high contact angles.
Vocal matching and intensity of begging calls are associated with a forebrain song circuit in a generalist brood parasite
Authors: Liu Wan‐Chun , Rivers James W. , White David J. 
Published: September 2015

ABSTRACTVocalizations produced by developing young early in life have simple acoustic features and are thought to be innate. Complex forms of early vocal learning are less likely to evolve in young altricial songbirds because the forebrain vocal‐learning circuit is underdeveloped during the period when early vocalizations are produced. However, selective pressure experienced in early postnatal life may lead to early vocal learning that is likely controlled by a simpler brain circuit. We found the food begging calls produced by fledglings of the brown‐headed cowbird (Molothrus ater), a generalist avian brood parasite, induced the expression of several immediate early genes and early circuit innervation in a forebrain vocal‐motor pathway that is later used for vocal imitation. The forebrain neural activity was correlated with vocal intensity and variability of begging calls that appears to allow cowbirds to vocally match host nestmates. The begging‐induced forebrain circuits we observed in fledgling cowbirds were not detected in nonparasitic passerines, including species that are close relatives to the cowbird. The involvement of forebrain vocal circuits during fledgling begging and its association with vocal learning plasticity may be an adaptation that provides young generalist brood parasites with a flexible signaling strategy to procure food from a wide range of heterospecific host parents. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 615–625, 2016
Growth differentiation factor 15 (GDF‐15) in patients admitted for acute heart failure: results from the RELAX‐AHF study
Authors: Cotter Gad , Voors Adriaan A. , Prescott Margaret F. , Felker G. Michael , Filippatos Gerasimos , Greenberg Barry H. , Pang Peter S. , Ponikowski Piotr , Milo Olga , Hua Tsushung A. , Qian Min , Severin Thomas M. , Teerlink John R. , Metra Marco , Davison Beth A. 
Published: September 2015

BackgroundGrowth differentiation factor 15 (GDF‐15) was found to be upregulated in patients with chronic heart failure (HF) and associated with disease severity, however, data on patients with acute heart failure (AHF) is lacking.Methods and resultsLevels of GDF‐15 were measured at pre‐specified time‐points (baseline and at days 2, 5, 14, and 60) in patients enrolled in the placebo‐controlled RELAXin in Acute Heart Failure (RELAX‐AHF) study, which examined the effect of serelaxin in 1161 patients with AHF, systolic blood pressure >125 mmHg, and mild to moderate renal impairment. Neither baseline nor changes in GDF‐15 were associated with the degree of dyspnoea or dyspnoea relief. After adjustment for baseline characteristics, baseline GDF‐15 was not associated with the composite endpoint of heart failure or renal failure (HF/RF) readmission at 60 days/cardiovascular (CV) death or CV death at 180 days. In contrast, larger increases in GDF‐15 levels at days 2 and 14 were associated with a greater risk of 60‐day HF/RF rehospitalizations/CV death and CV death at 180 days. Serelaxin treatment was associated with significantly larger decreases of GDF‐15 at days 2 and 5 than placebo.ConclusionsIn AHF patients enrolled in the RELAX‐AHF study, increases in GDF‐15 levels, but not baseline measurements, were associated with a greater likelihood of adverse outcomes. Serelaxin administration was associated with greater decreases in GDF‐15 compared with placebo.
Self‐Assembly Growth and Photocatalytic Performance of Nanostructured Copper Compounds
Authors: Jiang Tingting , Wang Yongqian , Meng Dawei , Kong Junhan , Jia Hanxiang , Wang Zhengshu 
Published: September 2015

AbstractFlowerlike CuO structures were synthesized by a simple chemical method. These 3D structures are formed by self‐assembly growth of smaller nanosheets as basic building units. Their crystalline phase, morphology, and optical properties were characterized by XRD, field‐emission SEM, and UV/Vis absorption spectroscopy. The effect of annealing on the morphology and properties of nanostructured Cu(OH)2/CuO was also investigated. The obtained CuO nanosheets with highly energetic (111) facets have excellent capacity for absorbing visible light, and their band‐gap energies, which were evaluated from the UV/Vis spectrum, range from 1.33 to 1.70 eV. Hence, their photocatalytic performance in the degradation of methyl blue (MB) was evaluated, and the highest photocatalytic degree of degradation of MB was 93.3 %. Further, the growth mechanism of the transformation from Cu(OH)2 nanowires (or nanoscrolls) to 3D CuO structures is discussed.
Hydroformylation of vegetable oils: More than 50 years of technical innovation, successful research, and development
Authors: Vanbésien Théodore , Monflier Eric , Hapiot Frédéric 
Published: September 2015

To address key sustainability challenges, it is now necessary to develop eco‐friendly alternatives to the use of petroleum resources. As such, the valorization of vegetable oils into added‐value products has become of major interest. While most of the reactions dealing with oils are related to their ester function, reactions have been developed to functionalize their CC double bonds. For example, the catalytic hydroformylation of vegetable fatty compounds enables the conversion of their CC double bonds into aldehydes. The reaction is atom‐economic and can be implemented under homogeneous, heterogeneous, or biphasic conditions. The catalytic hydroformylation of unsaturated fatty compounds has recently experienced a revival. The aim of the present article is to summarize current knowledge on the topic. The main salient results obtained since the 1960s are discussed and compared.More than 50 years of technical innovation, successful research, and development in triglycerides and FAME hydroformylation are summarized in this review article.
Epoxy fatty acids in used frying fats and oils, edible oils and chocolate and their formation in oils during heating
Authors: Brühl Ludger , Weisshaar Rüdiger , Matthäus Bertrand 
Published: September 2015

The occurrence of monoepoxy fatty acids in used frying oils and in other common foods has been determined. Monoepoxy fatty acids with trans‐9,10‐ and cis‐9,10‐epoxystearate and trans‐12,13‐, trans‐9,10‐, cis‐12,13‐ and cis‐ 9,10‐epoxyoctadecenoate were found at average levels of 3.7 g/kg in used frying fats and oils, but also at about 2 g/kg in the fat fraction of chocolate. They were also detected in pumpkin seed, sweet almond, groundnut, sunflower, and olive oils at average levels of 3.4, 1.7, 1.4, 1.0, and 0.2 g/kg, respectively. Their formation during heating at 175°C was observed for sunflower, rapeseed, soybean, and linseed oil and compared with the increase of polar compounds and polymerized triacylglycerols as other important quality indicators for frying oils. During heating for 16 h, the level of monoepoxy fatty acids increased to about 30, 18, 8, and 4 g/kg for olive, sunflower, linseed, and rapeseed oils, respectively. The influence of the heating temperature was surveyed for refined soybean oil at 160, 170, 180, and 200°C. Heating of two sets of five different refined and virgin rapeseed oils revealed a significant lower formation of monoepoxy fatty acids for refined oils at a median level of 4.6 g/kg compared to7.7 g/kg for virgin oils.Practical applications: Determination of fatty acid methyl esters is one of the most common analyses for the evaluation of oils and fats. The assessment of the monoepoxy fatty acids as part of these analyses can provide a first indication about used frying fats and oils, which reached the end of their applicability. The formation of monoepoxy fatty acids is affected by the fatty acid composition of the oil, the heating temperature, and the production of the oil. Therefore, frying oils may contain varying amounts of monoepoxy fatty acids at the maximum limit for polar compounds and polymerized triacylglycerols as used in the official food control. However, all used frying oils investigated by the official food control showing more than 7 g/kg of monoepoxy fatty acids had to be rejected due to the limits exceeded for polar compounds and polymerized triacylglycerols. Therefore, this limit of 7 g/kg monoepoxy fatty acids level is proposed as a level for screening the usability of used frying fats and oils.Epoxy fatty acids are formed in oils and fats during frying and heating. In addition, they are also detectable in unheated foods like chocolate and pumpkin seed oil. Frying fats and oils heated too much show contents of monoepoxy fatty acids above 7 g/kg.
Effective lipophilic antioxidant enzymatically derived from Canadian crabapple
Authors: Aladedunye Felix , Matthäus Bertrand 
Published: September 2015

Phloridzyl octadecanoate was prepared by enzymatic reaction between the native phloridzin in Canadian crabapple (Malus baccata) extract and octadecanoic acid in the presence of Candida antarctica lipase. The antioxidant activity of the modified extract was assessed in rapeseed oil during accelerated storage at 65°C and frying at 180°C. Addition of 0.1% modified extract to refined, bleached, and deodorized rapeseed oil significantly improved storage stability with 40.7% decrease in the formation of lipid hydroperoxides at the end of the 7‐day storage compared to rapeseed control sample without extract; however, no significant difference was observed in the potency of the modified extract and that of the native extract. On the contrary, the modified extract offered markedly better protection to the rapeseed substrate during frying, inhibiting polar component formation, and polymerization of triacylglycerol by up to 44%, compared to 26% by the native extract. At the end of the frying, French fries prepared in the presence of modified extract retained significantly more tocopherols than those prepared with the native extract indicating better protection of the oil's endogenous antioxidants by the modified phenolic extract.Practical applications: Poor lipophilicity is a major challenge to the application of natural polyphenolic compounds in edible oils. Equally challenging is the development of natural antioxidants that can maintain effectiveness under the stringent dynamic conditions of frying. Results from the current study demonstrated the possibility of overcoming these challenges, providing food processors with lipophilic natural antioxidants of practical importance in the frying process.Improving the lipophilicity of the polyphenolic components of Canadian crabapple's extract resulted in enhanced antioxidant and antipolymerization activities during frying, with consequent decreased in: Total polar materials (TPM); di‐ and polymerized triacylglycerols (DPTG); formation of non‐volatile carbonyl compounds assessed by the anisidine value (AnV); and rate of endogenous tocopherol degradation. However, no change in activity was observed under storage conditions.
Lewis‐Acid‐Catalysed Friedel–Crafts Alk­ylation of Donor–Acceptor Cyclopropanes with Electron‐Rich Benzenes to Generate 1,1‐Diarylalkanes
Authors: Kim Areum , Kim Sung‐Gon 
Published: September 2015

AbstractA Lewis‐acid‐catalysed Friedel–Crafts alkylation of donor–acceptor cyclopropanes with electron‐rich aromatic compounds is described. The reaction uses Yb(OTf)3 as the catalyst, producing the desired Friedel–Crafts products with a wide range of functional groups and substitution patterns in good yield. This synthetic approach allows the construction of 1,1‐diarylalkane derivatives, which are present in numerous biologically active compounds.
Alumina Polished Glassy Carbon Electrode as a Simple Electrode for Lower Potential Electrochemical Detection of Dopamine in its Sub‐micromolar Level
Authors: Thirumalraj Balamurugan , Palanisamy Selvakumar , Chen Shen‐Ming , Sayee Kannan R. 
Published: September 2015

AbstractThe electrochemical behaviour of dopamine (DA) at a cleaned and alumina polished glassy carbon electrode (GCE) was studied using cyclic voltammetry (CV). The CV studies revealed that alumina polished GCE (AGCE) shows an enhanced oxidation peak current response with 217 mV negative potential shift towards DA than that of cleaned GCE. The differential pulse voltammetry result shows that the AGCE detects the DA in the linear concentration ranges from 0.15 to 25.25 µmol L−1. The limit of detection was calculated as 0.046 µmol L−1 with a sensitivity of 3.74 µA µmol L−1 cm−2 for the determination of DA. The fabricated AGCE shows a satisfactory selectivity, practicality along with appreciable repeatability and reproducibility.
Enhanced Biosensing of Bisphenol A Using a Nanointerface Based on Tyrosinase/Reduced Graphene Oxides Functionalized with Ionic Liquid
Authors: Li Rui , Wang Yanying , Deng Yinghua , Liu Guishen , Hou Xiaodong , Huang Yina , Li Chunya 
Published: September 2015

AbstractReduced graphene oxide (rGO) nanosheets functionalized with 1,3‐di(4‐amino‐1‐pyridinium) propane tetrafluoroborate ionic liquid (DAPPT) was successfully synthesized and fully characterized. DAPPT‐rGO nanosheets were coated to a glassy carbon electrode (GCE) surface to immobilize tyrosinase (Tyr). The Tyr‐DAPPT‐rGO/GCE was characterized with scanning electronic microscopy and electrochemical impedance spectroscopy. The biosensor shows a linear response to bisphenol A (BPA) in the concentration range of 1.0×10−9∼3.8×10−5 mol L−1. The detection limit was calculated to be 3.5×10−10 mol L−1 (S/N=3). The practical application was demonstrated by determining BPA leaching from commercial plastic drinking bottles.
Ultrasensitive Electrochemical Sensor for Maltol in Wines Using Graphene Oxide‐Wrapped Amino‐Functionalized Carbon Sphere as Sensing Electrode Materials
Authors: Gan Tian , Lv Zhen , Liu Ning , Sun Junyong , Shi Zhaoxia , Zhao Aixia 
Published: September 2015

AbstractWe reported an electrochemical sensor with specificity toward maltol with rapid response and high sensitivity, using graphene oxide (GO)‐wrapped amino‐functionalized carbon sphere (ACS) hybrids as the conductive channel. The results indicated that a well‐organized structure was successfully prepared, based on specific electrostatic attractions between the ACS and the GO nanosheets. Next, a sensitive and selective electrochemical sensor was successfully constructed for the direct detection of maltol by casting a GO‐ACS film onto the surface of a glassy carbon electrode. The oxidative peak current increased linearly with the concentration of maltol in the range of 0.1 µM∼0.8 mM using differential pulse voltammetry, and the detection limit was 24 nM with S/N=3.
Damage of Siloxanes on Ni‐YSZ Anode Supported SOFC Operated on Hydrogen and Bio‐Syngas
Authors: Madi H. , Diethelm S. , Poitel S. , Ludwig C. , Van herle J. 
Published: September 2015

AbstractThis work presents the poisoning effect of organic oxo‐silicon compounds (siloxanes) which are generally found in sewage biogas. Lifetime and durability associated with solid oxide fuel cell (SOFC) technology is strongly related to the amount of contaminants that reach the stack. Several experiments on Ni anode‐supported (AS) single cells are performed in order to clarify the mechanism of degradation and also the possibility of cell performance recovery. Three experiments focus on the degradation and recovery of AS Ni‐YSZ fed with H2, co‐feeding 5 ppm D4‐siloxane (octamethylcyclotetrasiloxane, C8H24O4Si4) as representative compound for the organic silicon species, at 800 °C. A fourth experiment focuses on the durability of the AS Ni‐YSZ cell with variable concentrations of the impurity (0–5 ppm), during steady state polarization (0.25 A cm−2) for 250 h, using simulated biogas‐reformate fuel H2/CO/CO2/H2O: irreversible degradation was observed with the D4‐impurity feed in the anode gas. Post‐test scanning electron microscopy (SEM) results indicate formation of SiO2(s) deposits, which block pores and reduce the TPB length.
Microstructural and Electrical Characterization of Plasma Sprayed Cu‐Mn Oxide Spinels as Coating on Metallic Interconnects for Stacking Solid Oxide Fuel Cells
Authors: Spotorno R. , Piccardo P. , Perrozzi F. , Valente S. , Viviani M. , Ansar A. 
Published: September 2015

AbstractInterconnect coatings are extremely important to ensure an optimal performance of a solid oxide fuel cell (SOFC) stack. Nowadays the most common material used to produce SOFC interconnects is a ferritic stainless steel (FSS) rich in chromium which is much less expensive than the previously used ceramic interconnects. Nevertheless interconnects have to be coated in order to provide protection from the aggressive environment that surrounds them and reduce chromium species migration to the cell's cathode. In this work three different coatings were applied to Crofer® 22 H substrates via atmospheric plasma spraying (APS): two different stoichiometries of copper manganese oxide (CuxMn3–xO4, where x = 1.4 and 1.5) and one of cobalt manganese oxide (CoxMn3–xO4, where x = 1.5), considered the state of the art coating for SOFC interconnects. X‐ray diffraction (XRD) was used to check the composition of deposited layers. Area specific resistance (ASR) of samples has been characterized for different samples in the range 673–1,073 K and during a 100 hours ageing test at 1,073 K. Microstructural changes and Cr‐barrier properties have been characterized by SEM‐EDX analyses.