bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost implications of intraprocedural thrombotic events during PCI
Authors: Plent Stephanie , Fan Weihong , Kirtane Ajay , Brener Sorin J. , Genereux Philippe , Mehran Roxana , Pinto Duane S. , McEntegart Margaret , Cohen David J. , Stone Gregg W. 
Published: February 2015

ObjectivesWe sought to estimate the direct costs (in‐hospital and 30‐day) associated with an intraprocedural thrombotic event (IPTE) among patients with non‐ST‐segment elevation acute coronary syndromes (NSTEACS) undergoing percutaneous coronary intervention (PCI).BackgroundPatients with IPTE have higher rates of in‐hospital and 30‐day major adverse cardiac events than patients without IPTE. The extent to which IPTE also add to medical costs is unknown.MethodsHospital costs for patients in the ACUITY Trial were compared between patients with and without IPTE. Adjusted comparisons were performed using generalized linear models (GLMs). All costs are reported in 2012 US dollars.ResultsA total of 1,307 patients with both core laboratory‐based angiographic assessment and detailed economic data were included in the final study population. IPTE occurred in 52 patients (4.0%). Median in‐hospital costs were higher in patients with IPTE than in those without IPTE ($23,719 vs. $18,419, P = 0.01). Thirty‐day median costs were also higher for IPTE patients ($23,719 vs. $19,556, P = 0.05). After adjusting for baseline differences, IPTE was associated with 19.5% (95% CI: [2.8–38.8%], P = 0.02) and 18.9% (95% CI: [1.2–39.7%], P = 0.04) increases in in‐hospital and 30‐day costs, respectively. These relative differences represent median increases of $3,592 in initial hospital costs and $3,696 in 30‐day costs.ConclusionsThe occurrence of IPTE during the index PCI in patients with NSTEACS is associated with substantial increases in‐hospital and 30‐day costs. These findings suggest that strategies to prevent IPTE may be associated with important cost offsets as well as improved clinical outcomes. © 2015 Wiley Periodicals, Inc.
Natural ear rings
Authors: Sabaretnam Mayilvaganan , Virupakshaiah Akash , Baruah Rishiraj 
Published: February 2015

Key Clinical MessageEar lobe keloids are common following ear piercing and these lesions are conspicuous and cosmetically unappealing. Multiple methods including surgery, radiotherapy, anti mitotic agents, silicone sheet, pressure clips, and cryotherapy have been used. The Challenge is to have a good cosmetic outcome with minimal recurrence.
Disseminated Cryptococcal infection in an immunocompetent host mimicking plasma cell disorder: a case report and literature review
Authors: Abid Muhammad Bilal , De Mel Sanjay , Limei Michelle Poon 
Published: February 2015

Key Clinical MessageCryptococcosis is a potentially fatal fungal infection caused mainly by Cryptocococcus neoformans (CN) species and it rarely infects immunocompetent hosts. The outcomes are better only if the condition is suspected and diagnosed early and treatment is instituted.
Copper deficiency mimicking myelodysplastic syndrome
Authors: Dalal Neil , Hooberman Arthur , Mariani Rachel , Sirota Ronald , Lestingi Timothy 
Published: February 2015

Key Clinical MessageCopper deficiency is a rare cause of pancytopenia that may be mistaken for myelodysplastic syndrome. Cytoplasmic vacuolization in erythroid and myeloid precursors is found on bone marrow examination. Patients with a history of abdominal surgery who present with anemia and neutropenia with dysplastic changes should have copper levels checked.
Primary hydatid cyst of peritoneum presented as abdominal lump: a rare presentation
Authors: Pandya Jayashri S. , Bhambare Manoj R. , Waghmare Sudatta B. , Patel Ajit R. 
Published: February 2015

Key Clinical MessageThe incidence of primary hydatid cyst of peritoneum is 2%. It can present as a palpable abdominal lump. The differential diagnosis is cystic ovarian tumor clinically and radiologically. Peritoneal hydatid disease should be included in differential diagnosis of sonographically diagnosed pelvic cystic lesion.
Single Crystal to Single Crystal (SC‐to‐SC) Transformation from a Nonporous to Porous Metal–Organic Framework and Its Application Potential in Gas Adsorption and Suzuki Coupling Reaction through Postmodification
Authors: Sen Rupam , Saha Debraj , Koner Subratanath , Brandão Paula , Lin Zhi 
Published: March 2015

AbstractA new amino‐functionalized strontium–carboxylate‐based metal–organic framework (MOF) has been synthesized that undergoes single crystal to single crystal (SC‐to‐SC) transformation upon desolvation. Both structures have been characterized by single‐crystal X‐ray analysis. The desolvated structure shows an interesting 3D porous structure with pendent NH2 groups inside the pore wall, whereas the solvated compound possesses a nonporous structure with DMF molecules on the metal centers. The amino group was postmodified through Schiff base condensation by pyridine‐2‐carboxaldehyde and palladium was anchored on that site. The modified framework has been utilized for the Suzuki cross‐coupling reaction. The compound shows high activity towards the CC cross‐coupling reaction with good yields and turnover frequencies. Gas adsorption studies showed that the desolvated compound had permanent porosity and was microporous in nature with a BET surface area of 2052 m2 g−1. The material also possesses good CO2 (8 wt %) and H2 (1.87 wt %) adsorption capabilities.
Protic Anions [H(B12X12)]− (X=F, Cl, Br, I) That Act as Brønsted Acids in the Gas Phase
Authors: Jenne Carsten , Keßler Mathias , Warneke Jonas 
Published: March 2015

AbstractThe acidity of protic cations and neutral molecules has been studied extensively in the gas phase, and the gas‐phase acidity has been established previously as a very useful measure of the intrinsic acidity of neutral and cationic compounds. However, no data for any anionic acids were available prior to this study. The protic anions [H(B12X12)]− (X=F, Cl, Br, I) are expected to be the most acidic anions known to date. Therefore, they were investigated in this study with respect to their ability to protonate neutral molecules in the gas phase by using a combination of mass spectrometry and quantum‐chemical calculations. For the first time it was shown that in the gas phase protic anions are also able to protonate neutral molecules and thus act as Brønsted acids. According to theoretical calculations, [H(B12I12)]− is the most acidic gas‐phase anion, whereas in actual protonation experiments [H(B12Cl12)]− is the most potent gas‐phase acidic anion for the protonation of neutral molecules. This discrepancy is explained by ion pairing and kinetic effects.
Diffusion Length and Langevin Recombination of Singlet and Triplet Excitons in Organic Heterojunction Solar Cells
Authors: Ompong David , Singh Jai 
Published: March 2015

AbstractWe derived new expressions for the diffusion length of singlet and triplet excitons by using the Föster and Dexter transfer mechanisms, respectively, and have found that the diffusion lengths of singlet and triplet excitons are comparable. By using the Langevin recombination theory, we derived the rate of recombination of dissociated free charges into their excitonic states. We found that in some organic polymers the probabilities of recombination of free charge carriers back into the singlet and triplet states are approximately 65.6 and 34.4 %, respectively, indicating that Langevin‐type recombination into triplet excitons in organic semiconductors is less likely. This implies that the creation of triplet excitons may be advantageous in organic solar cells, because this may lead to dissociated free charge carriers that can be collected at their respective electrodes, which should result in better conversion efficiency.
Hydrologic remediation for the Deepwater Horizon incident drove ancillary primary production increase in coastal swamps
Authors: Middleton Beth A. , Johnson Darren , Roberts Brian J. 
Published: February 2015

AbstractAs coastal wetlands subside worldwide, there is an urgency to understand the hydrologic drivers and dynamics of plant production and peat accretion. One incidental test of the effects of high rates of discharge on forested wetland production occurred in response to the 2010 Deepwater Horizon incident, in which all diversions in Louisiana were operated at or near their maximum discharge level for an extended period to keep offshore oil from threatened coastal wetlands. Davis Pond Diversion was operated at six times the normal discharge levels for almost 4 months, so that Taxodium distichum swamps downstream of the diversion experienced greater inundation and lower salinity. After this remediation event in 2010, above‐ground litter production increased by 2.7 times of production levels in 2007–2011. Biomass of the leaf and reproductive tissues of several species increased; wood litter was minimal and did not change during this period. Root production decreased in 2010 but subsequently returned to pre‐remediation values in 2011. Both litter and root production remained high in the second growing season after hydrologic remediation. Annual tree growth (circumference increment) was not significantly altered by the remediation. The potential of freshwater pulses for regulating tidal swamp production is further supported by observations of higher T. distichum growth in lower salinity and/or pulsed environments across the U.S. Gulf Coast. Usage of freshwater pulses to manage altered estuaries deserves further consideration, particularly because the timing and duration of such pulses could influence both primary production and peat accretion. © 2015 The Authors. Ecohydrology published by John Wiley & Sons Ltd.
Pathogenic functions of B cells in autoimmune diseases: IFN‐γ production joins the criminal gang
Authors: Fillatreau Simon 
Published: February 2015

B‐cell depletion therapy has emerged as a powerful strategy to intercept the progression of T‐cell‐mediated autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, or relapsing remitting multiple sclerosis. However, its mode of action remains incompletely defined, reflecting our incomplete understanding of the pathogenic functions of B cells in such pathologies. B cells can contribute to immune responses through the production of antibodies, presentation of antigen to T cells, and production of cytokines. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2015. 45: 988–998], Olalekan et al. demonstrate that IFN‐γ production by B cells is essential for the development of arthritis in mice. Lack of IFN‐γ expression in B cells results in reduced autoimmune T‐cell responses and autoantibody levels, impacting the arthritogenic reaction akin to that in B‐cell depletion therapy. Together with other reports, the article by Olalekan et al. emphasizes the importance of cytokine‐producing B cells in the pathogenesis of autoimmune diseases. In this commentary, I discuss how these findings shed new light on the roles of B cells as drivers of autoimmune pathogenesis, and how they more generally contribute to our understanding of the role of B cells in immunity.
Fingerprinting 2,3,7,8-tetrachlorodibenzodioxin contamination within the lower Passaic River
Authors: Quadrini James D. , Ku Wen , Connolly John P. , Chiavelli Deborah A. , Israelsson Peter H. 
Published: February 2015

Abstract

The lower Passaic River is an operable unit of the Diamond Alkali Superfund site at 80 and 120 Lister Avenue in Newark, New Jersey, USA. Between 1948 and 1969, the Diamond Shamrock Chemicals Company and its predecessors manufactured chemicals such as pesticides and phenoxy herbicides, including 2,4,5-trichlorophenol, which is a precursor to 2,4,5-trichlorophenoxyacetic acid, one of the primary components used to make the military defoliant Agent Orange. A by-product of this manufacturing process was 2,3,7,8-tetrachlorodibenzodioxin (2,3,7,8-TCDD), and the site is considered the dominant source of 2,3,7,8-TCDD to the lower Passaic River and its environs. Several investigators have identified the ratio of 2,3,7,8-TCDD to total TCDD as a fingerprint for the site source. The present study presents data that establish polychlorinated dibenzodioxin/polychlorinated dibenzofuran (collectively, PCDD/F) congener and homolog fingerprints of soil and sump samples from the site. It then compares those fingerprints to the PCDD/F congener and homolog patterns in lower Passaic River sediments. The similarity of the patterns in lower Passaic River sediments to the site fingerprint indicates the site is the dominant source of the 2,3,7,8-TCDD in sediments within approximately the lower 14 miles of the lower Passaic River, excluding, for the purposes of the present discussion, Newark Bay. In addition, PCDD/F congener data indicate that the ratio of 1,3,7,8-TCDD to 2,3,7,8-TCDD is another marker of the site and corroborates the findings from the other fingerprints. Environ Toxicol Chem 2015;34:1485–1498. © 2015 The Authors. Published by SETAC.
Rates and product identification for trenbolone acetate metabolite biotransformation under aerobic conditions
Authors: Cole Emily A. , McBride Samantha A. , Kimbrough Kaitlin C. , Lee Jaewoong , Marchand Eric A. , Cwiertny David M. , Kolodziej Edward P. 
Published: February 2015

Abstract

Trenbolone acetate metabolites are endocrine-active contaminants discharged into the aquatic environment in runoff from agricultural fields, rangelands, and concentrated animal feeding operations. To investigate the environmental fate of these compounds and their biotransformation mechanisms, the authors used inocula from a variety of different water sources and dosed biologically active microcosms with approximately 1400 ng/L of trenbolone acetate metabolites, including 17β-trenbolone, trendione, and 17α-trenbolone. To investigate aerobic biotransformation rates and interconversions between known trenbolone acetate metabolites, gas chromatography–tandem mass spectrometry was used to measure concentrations and assess product distributions as a function of time. High-resolution liquid chromatography–tandem mass spectrometry (LC-MS/MS) was used to characterize novel transformation products and potential transformation pathways. Kinetic analysis yields observed half-lives of approximately 0.9 d, 1.3 d, and 2.2 d for 17β-trenbolone, trendione, and 17α-trenbolone, respectively, at 20 °C, although colder conditions increased half-lives to 8.5 d and biphasic transformation was observed. Relative to reported faster attenuation rates in soils, trenbolone acetate metabolites are likely more persistent in aqueous systems. Product distributions indicate an enzymatic preference for biotransformation between trendione and 17β-trenbolone. The LC-MS/MS characterization indicates dehydrogenation products as the major detectable products and demonstrates that major structural elements responsible for bioactivity in steroids are likely retained during biotransformation. Environ Toxicol Chem 2015;34:1472–1484. © 2015 SETAC
Late follow‐up of the randomized radiation and concomitant high‐dose intra‐arterial or intravenous cisplatin (RADPLAT) trial for advanced head and neck cancer
Authors: Heukelom Jolien , Lopez–Yurda Marta , Balm Alfons J. M. , Wijers Oda B. , Buter Jan , Gregor Theo , Wiggenraad Ruud , de Boer Jan Paul , Tan I. Bing , Verheij Marcel , Sonke Jan‐Jakob , Rasch Coen R. 
Published: February 2015

ABSTRACTBackgroundThe radiation and concomitant high‐dose intra‐arterial or intravenous cisplatin (RADPLAT) phase III trial compared intra‐arterial (IA) to intravenous (IV) cisplatin‐based chemoradiation for head and neck cancer. Long‐term efficacy and toxicity are reported after a median follow‐up of 7.5 years.MethodsPatients with inoperable squamous cell carcinoma (SCC) of the oropharynx, oral cavity, or hypopharynx, were randomized between radiotherapy (RT) + IA cisplatin 150 mg/m2, followed by systemic rescue or RT + I.V. cisplatin 100 mg/m2. RT consisted of 46 Gy to the affected and elective areas, followed by a boost of 24 Gy.ResultsAmong 237 patients, 57 recurred locally, 35 regionally, and 80 locoregionally. There were 32 second primary tumors, 65 distant metastases, and 154 deaths. Locoregional control and overall survival were not different between the treatment arms. Late dysphagia was worse in the I.V. arm (log‐rank p = .014).ConclusionIA cisplatin did not improve tumor control compared to I.V. administered cisplatin, despite the higher dose in IA delivery of the drug. © 2015 Wiley Periodicals, Inc. Head Neck 38: E488–E493, 2016
A Triply Divergent Reagent for Glycoprotein Synthesis
Authors: De Munari Sonia , Schiffner Torben , Davis Benjamin G. 
Published: March 2015

AbstractChemical synthesis of glycoproteins through three different strategies, from the same reagent, is herein described. The flexibility of this system, which allows the comparison of different linkage motifs between the same glycan and protein, is shown by one‐step diversification of a GlcNAc‐ylating reagent and its application in both site‐specific and non‐site‐specific glycoprotein synthesis to create different conjugates from common representative protein scaffolds.
Viscoelasticity of hyaluronic acid‐gelatin hydrogels for vocal fold tissue engineering
Authors: Kazemirad Siavash , Heris Hossein K. , Mongeau Luc 
Published: February 2015

AbstractCrosslinked injectable hyaluronic acid (HA)‐gelatin (Ge) hydrogels have remarkable viscoelastic and biological properties for vocal fold tissue engineering. Patient‐specific tuning of the viscoelastic properties of this injectable biomaterial could improve tissue regeneration. The frequency‐dependent viscoelasticity of crosslinked HA‐Ge hydrogels was measured as a function of the concentration of HA, Ge, and crosslinker. Synthetic extracellular matrix hydrogels were fabricated using thiol‐modified HA and Ge, and crosslinked by poly(ethylene glycol) diacrylate. A recently developed characterization method based on Rayleigh wave propagation was used to quantify the frequency‐dependent viscoelastic properties of these hydrogels, including shear storage and loss moduli, over a broad frequency range; that is, from 40 to 4000 Hz. The viscoelastic properties of the hydrogels increased with frequency. The storage and loss moduli values and the rate of increase with frequency varied with the concentrations of the constituents. The range of the viscoelastic properties of the hydrogels was within that of human vocal fold tissue obtained from in vivo and ex vivo measurements. Frequency‐dependent parametric relations were obtained using a linear least‐squares regression. The results are useful to better fine‐tune the storage and loss moduli of HA‐Ge hydrogels by varying the concentrations of the constituents for use in patient‐specific treatments. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 283–290, 2016.
The Neutrophil Nucleus and Its Role in Neutrophilic Function
Authors: Carvalho Leonardo Olivieri , Aquino Elaine Nascimento , Neves Anne Caroline Dias , Fontes Wagner 
Published: February 2015

ABSTRACTThe cell nucleus plays a key role in differentiation processes in eukaryotic cells. It is not the nucleus in particular, but the organization of the genes and their remodeling that provides the data for the adjustments to be made according to the medium. The neutrophil nucleus has a different morphology. It is a multi‐lobed nucleus where some researchers argue no longer function. However, studies indicate that it is very probable the occurrence of chromatin remodeling during activation steps. It may be that the human neutrophil nucleus also contributes to the mobility of neutrophils through thin tissue spaces. Questions like these will be discussed in this small review. The topics include morphology of human neutrophil nucleus, maturation process and modifications of the neutrophil nucleus, neutrophil activation and chromatin modifications, causes and consequences of multi‐lobulated segmented morphology, and importance of the nucleus in the formation of neutrophil extracellular traps (NETs). J. Cell. Biochem. 116: 1831–1836, 2015. © 2015 Wiley Periodicals, Inc.
RE1‐Silencing Transcription Factor (Rest) is a Novel Regulator of Osteoblast Differentiation
Authors: Liu Bo , Cheng Shaohong , Xing Weirong , Pourteymoor Sheila , Mohan Subburaman 
Published: February 2015

ABSTRACTRE1‐silencing transcription factor (Rest) has been identified as a master negative regulator of neuronal differentiation. Nothing is known about Rest function in bone cells. In this study, we examined the Rest expression levels and role during osteoblast differentiation. We found that Rest is abundantly expressed in bone marrow stromal cells, calvarial osteoblasts, and MC3T3‐E1 osteoblasts. Treatment of primary osteoblasts with ascorbic acid (AA) down regulated Rest mRNA expression at an early stage, but not in later stages of differentiation. Consistent with treatment of primary cultures, AA treatment of MC3T3‐E1 cells significantly reduced Rest protein expression at day 3 and at day 8 after initiation of osteoblast differentiation. Treatment of bone marrow stromal cells with BMP‐2 and dexamethasone, but not IGF‐I for 3 days greatly decreased Rest mRNA expression. To test the function of Rest during osteoblast differentiation, Rest expression was knocked down in MC3T3‐E1 cell subclones segregated on the basis of ALP activity (differentiation status) using lentivirus expressing shRNA against Rest. An 80% knockdown of Rest expression decreased Osterix (Osx) expression by 52–57% and as a result, increased both basal and AA induced ALP expression and activity in the subclone that expresses low basal level of ALP (undifferentiated). By contrast, a 98% knockdown of Rest expression in cells that express high basal levels of ALP (differentiated cells) caused a significant reduction in Osx expression, basal and AA induced ALP expression and activity. These data suggest that Rest regulates early osteoblast differentiation via modulating Rest expression that is independent of Osx expression. J. Cell. Biochem. 116: 1932–1938, 2015. © 2015 Wiley Periodicals, Inc.
Biology and mechano‐response of tendon cells: Progress overview and perspectives
Authors: Sun Hui B. , Schaniel Christoph , Leong Daniel J. , Wang James H.‐C. 
Published: February 2015

ABSTRACTIn this review, we summarize the group discussions on Cell Biology & Mechanics from the 2014 ORS/ISMMS New Frontiers in Tendon Research Conference. The major discussion topics included: (1) the biology of tendon stem/progenitor cells (TSPCs) and the potential of stem cell‐based tendon therapy using TSPCs and other types of stem cells, namely, embryonic and/or induced pluripotent stem cells (iPSCs), (2) the biological concept and potential impact of cellular senescence on tendon aging, tendon injury repair and the development of degenerative disease, and (3) the effects of tendon cells' mechano‐response on tendon cell fate and metabolism. For each topic, a brief overview is presented which summarizes the major points discussed by the group participants. The focus of the discussions ranged from current research progress, challenges and opportunities, to future directions on these topics. In the preparation of this manuscript, authors consulted relevant references as a part of their efforts to present an accurate view on the topics discussed. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:785–792, 2015.