bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Family-based Approach to Cascade Genetic Testing in a Pediatric Cancer Genetics Clinic
Authors: Haider Rida , Desrosiers-Battu Lauren , Scollon Sarah , Stankiewicz Pawel , Lupo Philip , Plon Sharon 
Published: August 2024

Abstract

Hereditary cancer predisposition disorders account for up to 10% of all pediatric cancers. Genetic counseling for families of the proband includes risk assessment and recommendations for cascade genetic testing for first degree relatives, but there is no standardized method for cascade testing in place resulting in variability in how clinics approach cascade genetic testing. We explored the uptake and outcomes associated with a family-based approach to cascade testing, for non-syndromic cancer predisposition disorders, at a pediatric cancer genetics clinic serving an ethnically diverse patient population. A retrospective chart review was conducted to evaluate test uptake in the parents and siblings of 106 pediatric probands. The study included 99 mothers, 97 fathers, 116 full siblings, and 53 half siblings who were recommended testing due to genetic risk. Of these relatives, 156 (43%) had documentation of completed cascade testing within twenty four months after the proband's result disclosure. Completion of cascade testing varied by the type of family member and degree of relatedness. Forty-one percent of mothers (41/99) were tested in comparison to 26% of fathers (26/97) and 70.6% of full siblings (82/116) were tested compared to 13.2% of half siblings (7/53). Statistical analysis using chi-squared tests revealed that siblings were more likely to have completed testing than parents (p < 0.001). Furthermore, amongst parents, mothers were more likely to complete testing than fathers (p = 0.03) and amongst siblings, full siblings were more likely to complete testing than half siblings (< 0.001). The proband’s age (p = 0.008), parents’ preferred language (p = 0.002), and interpreter use during visit (p = 0.004) were the factors associated with differences in test uptake amongst siblings, whereas the proband’s race/ethnicity (p = 0.019) was the only factor associated with differences in test uptake amongst parents. The most common barriers noted in charts for lack of test completion included country of residence, lack of insurance, and loss to follow-up. In conclusion, we found that test uptake differed significantly among relatives of a proband with siblings being more likely to test than parents. We also found differences in the demographic and clinical factors associated with test uptake in parents and siblings. Future studies need to validate these differences and further explore the underlying cause of variation in test uptake among relatives.
Anterior Cruciate Ligament injury: A Comprehensive Clinical Profile -A longitudinal study
Authors: Sheenam Nagma , Gaur Ravi , Gonnade Nitesh Manohar , Dixit Abhinav , K Abins T , K Chinchu 
Published: August 2024

Abstract

Introduction: ACL injuries are common among athletes and individuals experiencing trauma, leading to instability and functional impairments. Post-ACL reconstruction, patients often face challenges like pain and reduced knee function, impacting their daily lives and sports participation. Methods This longitudinal observational study followed 98 ACL tear patients over three months with three subsequent assessments at preACLR, 1 month postACLR and 3 months post ACLR. Measures included Tegner Activity Scale, IKDC Subjective Knee Evaluation, Lysholm Knee Scoring Scale, pain scales, quadriceps thickness via ultrasound, and Rectus femoris and Vastus lateralis muscle activation via surface electromyography. Results Significant improvements were observed in Tegner Activity Scale scores (p < 0.001), IKDC scores (p < 0.001), Lysholm scores (p < 0.001), and pain scores (p < 0.001) over the study period. Ultrasonography and surface electromyography revealed ongoing quadriceps muscle atrophy and reduced neuromuscular function, highlighting the need for targeted rehabilitation. Conclusion Structured rehabilitation post-ACL reconstruction significantly improves functional outcomes and reduces pain. Challenges like muscle atrophy and decreased activation post-surgery emphasize the need for targeted rehabilitation strategies. Tailored programs are crucial for optimizing recovery, enhancing knee stability, and preventing long-term complications. Future research should refine protocols and ensure sustained improvements through long-term follow-up studies.
Bots Election: Unveiling the complex network of social botnets
Authors: Bigdeli Parsa , Moradi Parham , Jafari Reza 
Published: August 2024

Abstract

With the exponential growth of bots surpassing the near saturation of genuine users, a large socio-bot network has emerged. Botnets have evolved to exhibit significant social properties through their interactions with humans. This network has empowered bots with capabilities that cannot be observed locally; therefore, this study advocates examining bots as a complex network akin to human social networks. In our case study of Farsi Twitter users during Iran's 2021 presidential election, 71.2% of the users were identified as bots. By isolating the botnet, we analyzed the distinctions between bots and genuine users within complex networks, revealing a more robust, efficient, and controllable structure for information dissemination. To explore how following and retweeting actions influence each other, we classified bots based on their actions and examined the roles of each classification, the differences between the functional and structural core, and the impact of non-common bots on network controllability and regime transitions.Additionally, we observed how the activity of bots is limited within both the functional core and the entire system. Politically, our findings indicated that despite the candidates' use of bot accounts, political figures did not play a crucial role in controlling the botnet. We further explored the interactions between opposing political biases and the role of non-biased bots in bridging political divides and forming echo chambers.
Lung ultrasound elastography, microvascularization and metabolomic as non-invasive quantitative biomarkers for the aetiological diagnosis of pulmonary consolidations in children (LUSMET study)
Authors: Huerta-Calpe Sergi , Guitart Carmina , Carrasco-Jordan Josep L. , Salas Bárbara , Cambra Francisco José , Jordan Iolanda , Balaguer Mònica 
Published: August 2024

Abstract

Background: Lung ultrasound (LUS) and invasive blood biomarkers have been evaluated to improve bacterial pneumonia (BP) diagnosis, but it is still needed to assess the efficacy of some novel biomarkers such as Lung Shear Wave Elastography (LSWE), quantification of lung microvascularization ratio pattern by Superb Microvascular Imaging (SMI) or determination of urine metabolomic profile. These biomarkers, in conjunction with LUS findings, may be useful for the approach and diagnosis of patients with BP suspicion. After validating the image and biomarkers values acquisition procedure, the study will differentiate these values from the healthy ones and from other causes of lung consolidation. The aim of this study is to define a new non-invasive quantitative diagnostic protocol combining LSWE and SMI with LUS and, at once, urinary metabolomic profile to accurately diagnose BP.Method and design: This is a cohort study for validating the use and the utility of three novel non-invasive biomarkers, including a medical device. The study recruitment period will be from September 2024 up to September 2026. It will be conducted at the Paediatric Intensive Care Unit (PICU) of a tertiary children’s hospital in Spain and is planned to be developed in four phases. First, a biomarker measurement protocol will be defined (phase 1). After that, patients under 18 years of age without pulmonary pathology admitted to the PICU will be recruited to define the normal biomarker values (phase 2). Subsequently, patients under 18 years of age with lung consolidation admitted to the PICU will be recruited in order to determine the biomarker values in pathological lung tissue (phase 3). Finally, all results will be collected to define a new diagnostic BP score based on these non-invasive imaging and analytical biomarkers (phase 4).Conclusion: Our working group foresees that the new image non-invasive biomarkers (LSWE and SMI) and the determination of urinary metabolome will be capable of diagnosing BP without the need of the current invasive diagnostic methods (analytical variables and irradiating image tests). These new tools may be particularly useful in the paediatric population and, in addition of diagnosing BP, may allow differentiating between several aetiologies of lung consolidation.
Periorbital Nodular Fasciitis: A Case Report
Authors: Algarni Saad , Najmi Hatim , Alsawadi Hend , Alsaif Bayan , Alshammari Reem , Aleid Shaikah 
Published: August 2024

Abstract

Background
Nodular fasciitis (NF), also known as pseudosarcoma fasciitis, is defined as a benign, self-limiting, vascular, or fibrovascular proliferation. It is commonly found on the trunk and upper extremities. NF is rarely found in the orbit and periorbital regions, with only a few case studies reported since it was initially described by Font et al. in 1966. NF usually presents as a rapidly growing solitary tumor and is often mistaken for a sarcoma due to its high cellularity and increased mitotic activity.
Case presentation
We present a case of NF in a 41-year-old Saudi man with a 1-year history of a gradually enlarging left medial subbrow mass in the left eye. The mass was not associated with pain, visual disturbances, double vision, or a history of trauma. An external ophthalmic examination revealed a firm, oval mass over the nasal aspect of the superior orbital rim of the right eye. The mass was non-tender, measured 1 × 2 cm in diameter, and fixed to deep tissues. Computed tomography (CT) with contrast revealed a well-demarcated para-orbital soft tissue round lesion with peripheral enhancement occupying the nasal aspect of the superior orbital rim above the inner canthus. Debulking and incisional biopsies were performed, and the histopathological findings were consistent with those of NF.
Conclusions
NF is a rare benign tumor that infrequently presents in the periorbital region. It lacks distinctive features for a definitive diagnosis and should be suspected when imaging results are inconclusive. Management typically involves complete local excision or debulking.
Compressive properties and failure of aluminum/epoxy resin interpenetrating phase composites reinforced by glass fiber
Authors: Su Mingming , Zhou Zhiming , Wang Han 
Published: August 2024

Abstract

Aluminum/epoxy resin interpenetrating phase composites (IPCs) were directly strengthened by adding glass fiber of varying content (80 wt.%, 100 wt.%, 120 wt.% and 140 wt.%) inside the epoxy resin. The macro and micro structures of IPCs were intact, and the interface between aluminum and epoxy resin was well combined. As the content of glass fiber increased, the compressive strength of epoxy resin increased, but the failure was advanced, while IPCs displayed the opposite trend. IPCs exhibited three compression deformation modes, namely plastic deformation of aluminum, resin fracture and interface debonding. The digital image correlation and infrared thermal imager were used to characterize the apparent principal strain distribution and temperature distribution of IPCs to verify the deformation modes. The surface temperature damage evolution of IPCs included the rapid temperature rise stage, steady temperature stage and slight temperature drop stage, respectively, mainly corresponded to the linear elastic stage, plateau stage and densification stage in the stress-strain curves.
The utility of the new category by number of stations for lymph nodal involvement in non-small cell lung cancer
Authors: Motono Nozomu , Mizoguchi Takaki , Ishikawa Masahito , Iwai Shun , Iijima Yoshihito , Uramoto Hidetaka 
Published: August 2024

Abstract

Purpose
In the nineth edition of the TNM staging system, the new nodal involvement (N) subcategories to N2 for single-station involvement (N2a) and multiple-station involvement (N2b) has been adopted Although there are significant differences in survival rates for each group of pN categories in the nineth edition, it can be assumed that survival rates in pN1 and pN2a are relatively similar.
Methods
We retrospectively evaluated the utility of the new category by number of stations, such as None, Single station, and Multiple station for pN in 1000 NSCLC patients treated by pulmonary resection.
Result
Survival rates were significantly different in among None, Single station, and Multiple station (5-year RFS: None;79.6%, Single station;47.3%, Multiple station;24.2%, all groups p < 0.01. 8-year OS: None;78.7%, Single station;65.2%, Multiple station;33.6%, all groups p < 0.01). There were significant differences among each group categorized by number of pN station in multivariate analysis for RFS (None vs Single station; P < .01, None vs Multiple station; P < .01, Single station vs Multiple station; P < .01). There were significant differences among each group categorized by number of pN station in multivariate analysis for OS (None vs Single station; P = .04, None vs Multiple station; P < .01, Single station vs Multiple station; P < .01).
Conclusion
There were significant differences among None, Single station, and Multiple station in each survival curves, and in multivariate analysis for both RFS and OS. This category by number of pN station without dependence of location for lymph nodal involvement might be the new classification of lymph node involvement.
Trial registration
The Institutional Review Board of Kanazawa Medical University approved the protocol of this retrospective study (approval number: I392), and written informed consent was obtained from all patients
On the Influence of Multi-cue User Interfaces in Eliminating Cognitive Load of Repetitive Tasks in Augmented Reality
Authors: LI Xiangdong , JIN Xiaoli , YIN Kailin , NIU Yuting , GENG Weidong 
Published: August 2024

Abstract

Multi-cue user interfaces (MCUIs) are a typical set of graphical user interfaces that are commonly used in augmented reality because of its simultaneous encoding of multiple visual cues into interaction tasks. Previous investigations have proven the advantageous impacts of MCUIs on usability for one-time tasks. With the increasing prevalence of MCUIs in industrial environments, it is imperative to investigate the influence of MCUIs on users’ cognitive load for repetitive tasks. We replicated the repetitive processes of sorting parcels in modern warehouses and conducted a series of empirical investigations to assess the influence of MCUIs on cognitive load and perceived usability. The results showed the effectiveness of MCUIs in reducing cognitive load and physical fatigue and revealed the correlations between the participants’ task efficiency and the quantity of visual cues. In addition, the study unveiled the positive impact of MCUIs on the overall perceived usability, although the specific aspects -ease of use and overall satisfaction- are not affected.
Can Intra-Articular Daidzein Injection Reduce Oxidative Damage and Early Osteoarthritis in a Rabbit Temporomandibular Joint Model?
Authors: ERDAYANDI Gokce Elif , YILMAZ Onur , KERIMOGLU Gokcen , SAHIN Elif , dogan seda yilmaz 
Published: August 2024

Abstract

Background
Oxidative damage and inflammatory cytokines in osteoarthritis (OA) exacerbate the disease course. Daidzein (DZ) has antioxidant and anti-inflammatory effects. This study evaluated the early histopathological effects of intra-articular daidzein injection on experimentally induced osteoarthritis in rabbit TMJs.
Methods
The predictor variable was intra-articular injection of DZ or a saline control.The remaining 15 rabbits were randomly divided into 2 groups: an experimental group (9 rabbits) and a control group (6 rabbits). On days 1, 7, 14, and 21; 50 µl of saline solution was applied to the control group and 50 µl daidzein solution (1.8 mg/ml) to the experimental group. On day 21, the rabbits were sacrificed, and histopathological and biochemical evaluations were performed. The Shapiro-Wilk test was used to evaluate whether the variables in the study conformed to normal distribution. Mean ± SD (standard deviation) or median (interquartile range (IQR)) was used to show the descriptive statistics of the variables. T-test and Mann Whitney U test were used to compare the control and experimental groups for biochemical changes. The chi-square test was used to show the distribution of histopathological changes variables obtained within the scope of the study based on control and experimental groups. A P-value < 0.05 was considered significant for all evaluations.
Results
There were 8 and 6 animate treated with DZ and saline, respectively. There was no statistically significant difference between groups in articular cartilage (p = 0.3), osteochondral junction(p = 0.3), subchondral bone structure (p = 1.0) or chondrocyte appearance (p = 0.4). The experimental group showed significantly lower mean values for TOS (p = 0.002) and OSI (p = 0.007).
Conclusions
An intra-articular DZ injection appears to show limited reduction of oxidative damage and early OA in the rabbit TMJ. DZ might represent a promising natural compound with beneficial effects in the management of TMJ-OA.
Epithelial-mesenchymal transition and anoikis resistance induced by Ang2 in salivary adenoid cystic carcinoma
Authors: Min Zheng , Zhao Haihui , Zhong Xiaojuan , Jun Guo , Ping Zhang , Fei Wei , Yi Huang 
Published: August 2024

Abstract

Patients, who suffer from Salivary Adenoid Cystic Carcinoma (SACC), face a heightened risk of recurrent or metastatic disease attributed to significant neuroinvasion, even with standard treatment, highlighting the imperative for innovative treatment targets and approaches. Our research indicates that the expression of angiopoietin-2 (Ang2) in the cytoplasm and nucleus of SACC tissue is significantly higher than that of normal tissue adjacent to cancer, which is related to the pathological type of the tissue. Approximately 74.2% of SACC express Ang2, which promotes survival and lung metastasis. In SACC cells, downregulation of Ang2 inhibits cell migration and enhances cell apoptosis, and resistance to cell apoptosis is deemed essential for metastasis. The downregulation of Ang2 leads to the restoration of E-cadherin levels by facilitating the proteasome-dependent degradation of its suppressor Snail.Overexpression of Snail prevented the complete inhibitory effect of Ang2 on ACC cell migration, which was in line with the promotion of epithelial mesenchymal transition (EMT). The in vivo findings demonstrated reduced lung colonization in conjunction with the downregulation of Ang2. Our findings illustrate Ang2 triggers EMT and enhances metastasis in SACC, suggesting that Ang2 could act to be a promising therapeutic option towards individuals with SACC.
Correntropy based Low-rank Matrix Factorization with Multi-view Constraint Graph Learning for Multi-view Data Clustering
Authors: Du Yuanhua , Chen Pan , Zhou Nan , Chen Eryang , Shi Kaibo 
Published: August 2024

Abstract

With the increase in data pattern diversity, multi-view clustering has become a hot topic for researchers. However, most of the current multi-view clustering methods focus on unsupervised learning scenarios, which cannot utilize the label information in the data. Furthermore, they could not handle the outliers, which may exist in the data. In order to address these issues, this paper proposes a Correntropy-based Multi-view Low-rank Matrix Factorization (CMLMF) method for multi-view data semi-supervised clustering. In order to sufficiently utilize the local structure information, a correntropy-based multi-view constraint graph learning framework is proposed to extract the local structure hidden in the multi-view data adaptively. Furthermore, a correntropy-based multi-view Low-rank Matrix Factorization (LMF) model is proposed, which can be incorporated with the adaptive graph learning framework to extract the global reconstruction information of data. The label information is introduced by a constraint matrix, which can be utilized for both global reconstruction and local structure information learning without adding any hyperparameter. Due to the maximum correntropy criterion, the proposed method is robust against the outliers in the data in each view and helps to extract a more current consensus representation. An efficient solving algorithm based on accelerated Block Coordinate Update (BCU) is designed to solve the model. Experiments are conducted on five real-world datasets, and the proposed method is compared with ten state-of-the-art methods to evaluate the effectiveness of the CMLMF method. The results show that the proposed method performs better clustering in most cases.
Claroideoglomus etunicatum affects the diversity and composition of the rhizosphere microbial community to help tall fescue resist saline-alkali stress
Authors: Liu Hui , Zheng Yujie , Zhang Peiliang , Liu Lu 
Published: August 2024

Abstract

Arbuscular mycorrhizal fungi (AMF) and plant rhizosphere microbes reportedly enhance plant tolerance to abiotic stresses and promote plant growth in contaminated soils. Soil salinization represents a severe environmental problem. Although the influence of AMF in the phytoremediation of saline-alkali soils has been fully demonstrated, the underlying interactive mechanisms between AMF and rhizosphere microbes are still unclear. A greenhouse pot experiment was conducted to explore the effects of AMF (Claroideoglomus etunicatum) on tall fescue growth promotion and rhizosphere microbial community in saline-alkali soils. We aimed to investigate the mechanism of AMF affecting plant growth under saline-alkali stress conditions via interactions with rhizosphere microbes. We found that AMF significantly increased plant shoot, root and total biomass in the saline-alkali stress soil. AMF significantly increased the diversity of bacterial and fungal communities, and altered their composition: for bacteria, AMF inoculation treatment (M+) had higher relative abundance of Proteobacteria, Actinobacteriota and Firmicutes, and lower relative abundance of Acidobacteriota and Chloroflexi than no AMF application treatment (M-); for fungi, M + treatment had lower relative abundance of Ascomycota and higher relative abundance of Mortierellomycota than M- treatment. Furthermore, structural equation modeling (SEM) revealed that AMF promoted plant growth under saline-alkali stress conditions mainly by regulating plant rhizosphere soil bacterial communities. This study provides a theoretical basis for improving plant adaptation to saline-alkali stress through soil microbial management practices.
Flatness-Based Motion Planning and Control Strategy for Payload Positioning of an Overhead Crane
Authors: Nguyen Van Chung , Thi Hue Luu , Vu Minh Nhat , Khanh Hoa Bui Thi , Danh Huy Nguyen , Tung Lam Nguyen 
Published: August 2024

Abstract

This research paper investigates the application of a new advanced control strategy to a three-dimensional overhead crane (3DOC). Firstly, a time-optimal motion planning algorithm is developed based on differential flatness theory, which considers dynamic and control objective constraints. In addition, to improve robustness and disturbance effects, a Fixed-Time Extended State Observer (FxTESO) and a Terminal Sliding Mode Control (TSMC) are introduced. The FxESO provides accurate estimations of states and total disturbances in a fixed time, thereby enhancing the overall performance of the proposed method. Furthermore, the TSMC takes the estimations to ensure the tracking performance of the 3DOC and guarantees that control errors converge to zero in a fixed time. The proposed methodologies are verified through simulation studies and practical experiments in a physical 3DOC lab size. Finally, the comparison with the existing control strategy highlights the proposed methods' effectiveness in trajectory optimization, disturbance rejection, and overall system performance.