bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Resolution Downscaled Simulations of Warm-Season Extreme Precipitation Events in the Colorado Front Range under Past and Future Climates*
Authors: Mahoney Kelly , Alexander Michael , Scott James D. , Barsugli Joseph 
Published: July 2013

Abstract
A high-resolution case-based approach for dynamically downscaling climate model data is presented. Extreme precipitation events are selected from regional climate model (RCM) simulations of past and future time periods. Each event is further downscaled using the Weather Research and Forecasting (WRF) Model to storm scale (1.3-km grid spacing). The high-resolution downscaled simulations are used to investigate changes in extreme precipitation projections from a past to a future climate period, as well as how projected precipitation intensity and distribution differ between the RCM scale (50-km grid spacing) and the local scale (1.3-km grid spacing). Three independent RCM projections are utilized as initial and boundary conditions to the downscaled simulations, and the results reveal considerable spread in projected changes not only among the RCMs but also in the downscaled high-resolution simulations. However, even when the RCM projections show an overall (i.e., spatially averaged) decrease in the intensity of extreme events, localized maxima in the high-resolution simulations of extreme events can remain as strong or even increase. An ingredients-based analysis of prestorm instability, moisture, and forcing for ascent illustrates that while instability and moisture tend to increase in the future simulations at both regional and local scales, local forcing, synoptic dynamics, and terrain-relative winds are quite variable. Nuanced differences in larger-scale and mesoscale dynamics are a key determinant in each event's resultant precipitation. Very high-resolution dynamical downscaling enables a more detailed representation of extreme precipitation events and their relationship to their surrounding environments with fewer parameterization-based uncertainties and provides a framework for diagnosing climate model errors.
On the Connection between Continental-Scale Land Surface Processes and the Tropical Climate in a Coupled Ocean–Atmosphere–Land System
Authors: Ma Hsi-Yen , Mechoso C. Roberto , Xue Yongkang , Xiao Heng , Neelin J. David , Ji Xuan 
Published: July 2013

AbstractAn evaluation is presented of the impact on tropical climate of continental-scale perturbations given by different representations of land surface processes (LSPs) in a general circulation model that includes atmosphere–ocean interactions. One representation is a simple land scheme, which specifies climatological albedos and soil moisture availability. The other representation is the more comprehensive Simplified Simple Biosphere Model, which allows for interactive soil moisture and vegetation biophysical processes.The results demonstrate that such perturbations have strong impacts on the seasonal mean states and seasonal cycles of global precipitation, clouds, and surface air temperature. The impact is especially significant over the tropical Pacific Ocean. To explore the mechanisms for such impact, model experiments are performed with different LSP representations confined to selected continental-scale regions where strong interactions of climate–vegetation biophysical processes are present. The largest impact found over the tropical Pacific is mainly from perturbations in the tropical African continent where convective heating anomalies associated with perturbed surface heat fluxes trigger global teleconnections through equatorial wave dynamics. In the equatorial Pacific, the remote impacts of the convection anomalies are further enhanced by strong air–sea coupling between surface wind stress and upwelling, as well as by the effects of ocean memory. LSP perturbations over South America and Asia–Australia have much weaker global impacts. The results further suggest that correct representations of LSP, land use change, and associated changes in the deep convection over tropical Africa are crucial to reducing the uncertainty of future climate projections with global climate models under various climate change scenarios.
Aspects of Convective Boundary Layer Turbulence Measured by a Dual-Doppler Lidar System
Authors: Röhner Luisa , Träumner Katja 
Published: July 2013

Abstract
Special designed dual-Doppler setups can be used to retrieve simultaneous measurements of two wind components with high temporal resolution in several heights throughout the atmospheric boundary layer. During a field campaign in summer 2011, different scan strategies were performed to demonstrate the opportunities of obtaining variance profiles of the vertical and horizontal wind components in complex terrain. A simplified error analysis reveals the effects of the error propagation of the uncorrelated noise of the single lidar systems. A comparison shows that the course of the derived horizontal wind component is in accordance to in situ measurements. The dual-Doppler vertical wind velocity reflects the up- and downdrafts in a convective boundary layer and is even able to reflect a light rain event. The normalized profiles of the vertical velocity variances reproduce the well-known decrease from about one-third of the boundary layer height to its top. The horizontal velocity variance did not reveal a systematic behavior on the considered days.
Solar and Thermal Radiation Errors on Upper-Air Radiosonde Temperature Measurements
Authors: Philipona R. , Kräuchi A. , Romanens G. , Levrat G. , Ruppert P. , Brocard E. , Jeannet P. , Ruffieux D. , Calpini B. 
Published: July 2013

Abstract
Atmospheric temperature and humidity profiles are important for weather prediction, but climate change has increased the interest in upper-air observations asking for very high-quality reference measurements. This paper discusses an experimental approach to determine the radiation-induced error on radiosonde air temperature measurements. On the one hand, solar shortwave and thermal longwave radiation profiles were accurately measured during radiosonde ascents from the surface to 35-km altitude. On the other hand, air temperature was measured with several thermocouples on the same flight, simultaneously under sun-shaded and unshaded conditions. The radiation experiments reveal that thermal radiation errors on the very thin thermocouple of the Meteolabor SRS-C34 radiosonde are similar during night- and daytime. They produce a radiative cooling in the lower troposphere and the upper stratosphere, but a radiative heating in the upper troposphere and lower stratosphere. Air temperature experiments with several thermocouples, however, show that solar radiation produces a radiative heating of about +0.2°C near the surface, which linearly increases to about +1°C at 32 km (~10 hPa). The new solar radiation error profile was then applied to SRS-C34 measurements made during the Eighth WMO Intercomparison of High Quality Radiosonde Systems, held in Yangjiang, China, in July 2010. The effects of thermal and solar radiation errors are finally shown in contrast to the 10 other internationally used radiosonde systems, which were flown during this international campaign.
Burden and related factors in caregivers of young adults presenting bipolar and unipolar mood disorder
Authors: da Silva Giovanna Del Grande , Jansen Karen , Barbosa Luana Porto , Branco Jerônimo da Costa , Pinheiro Ricardo Tavares , Magalhães Pedro Vieira da Silva , Kapczinski Flávio , da Silva Ricardo Azevedo 
Published: July 2013

Background: Caregiver burden has been associated with caregivers’ mental disorders and need for support and information. However, the lack of quantitative studies and formal interventions aiming to lower burden levels in this population reflect the current negligence regarding this important issue. Aim: To identify burden levels and associated factors in caregivers of young adults with bipolar and unipolar mood disorder. Method: This is a cross-sectional study nested within a population-based cross-sectional study with young adults. Caregiver burden was assessed through the Burden Interview. Information about caregiver mental disorders (Axis I) and alcohol abuse were obtained through the Mini International Neuropsychiatric Interview (MINI) and the Cut-Down, Annoyed, Guilty and Eye-Opener (CAGE) questionnaire, respectively. Results: Caregiver burden was associated to caregiver’s mood and anxiety disorders, suicide risk and being the caregiver of young adults with depression disorder and bipolar disorder. Also, burden was higher among caregivers of bipolar individuals. When excluding the control group from the analysis, only mood and anxiety disorders remained associated to caregiver burden. Conclusions: Caregivers are affected by the young adult’s disorder even before a diagnosis has been given, with serious impairments in their lives. Thus, this is a subject in need of designing relevant strategies aiming to provide them with care.
Long-term effect of motivational interviewing on clinical and psychological outcomes and health-related quality of life in cardiac rehabilitation patients with poor motivation in Hong Kong: a randomized controlled trial
Authors: Chair Sek Ying , Chan Sally Wai-Chi , Thompson David R , Leung Kei-Pui , Ng Samuel Ka-Chiu , Choi Kai Chow 
Published: July 2013

Objective: To investigate the long-term effects of motivational interviewing on clinical outcomes, psychological outcomes, health-related quality of life among cardiac rehabilitation patients with poor motivation. Design: A randomized controlled trial with blind data collectors. Setting: Cardiac rehabilitation centre. Subjects: A total of 146 cardiac rehabilitation patients with poor motivation. Intervention: All participants received usual care, including exercise and education, while those in the experimental group also received 10 sessions of motivational interviewing, each lasting 30–45 minutes. Main measures: Clinical and psychological outcomes and health-related quality of life were assessed at baseline and at six, nine and 12 months for both groups. Result: There was no significant difference between the two groups at baseline on demographic and clinical outcomes except for monthly family income ( p = 0.034). Patients in the experimental group had higher increases in health-related quality of life (SF-36) scores in bodily pain (88.7 SD 16.7 vs. 87.6 SD 18.7 at month 12, p = 0.044) and role limitation owing to emotional problems (86.9 SD 19.2 vs. 78.6 SD 21.8 at month 9, p = 0.019; 85.8 SD 18.9 vs. 76.9 SD 23.9 at month 12, p = 0.022). No statistically significant group difference was found among other outcomes. Conclusion: The long-term effect of motivational interviewing on clinical and psychological outcomes and health-related quality of life in studied patients is limited.
White paper defining optimal palliative care in older people with dementia: A Delphi study and recommendations from the European Association for Palliative Care
Authors: van der Steen Jenny T , Radbruch Lukas , Hertogh Cees MPM , de Boer Marike E , Hughes Julian C , Larkin Philip , Francke Anneke L , Jünger Saskia , Gove Dianne , Firth Pam , Koopmans Raymond TCM , Volicer Ladislav ,   on behalf of the European Association for Palliative Care (EAPC)
Published: July 2013

Background: Dementia is a life-limiting disease without curative treatments. Patients and families may need palliative care specific to dementia. Aim: To define optimal palliative care in dementia. Methods: Five-round Delphi study. Based on literature, a core group of 12 experts from 6 countries drafted a set of core domains with salient recommendations for each domain. We invited 89 experts from 27 countries to evaluate these in a two-round online survey with feedback. Consensus was determined according to predefined criteria. The fourth round involved decisions by the core team, and the fifth involved input from the European Association for Palliative Care. Results: A total of 64 (72%) experts from 23 countries evaluated a set of 11 domains and 57 recommendations. There was immediate and full consensus on the following eight domains, including the recommendations: person-centred care, communication and shared decision-making; optimal treatment of symptoms and providing comfort (these two identified as central to care and research); setting care goals and advance planning; continuity of care; psychosocial and spiritual support; family care and involvement; education of the health care team; and societal and ethical issues. After revision, full consensus was additionally reached for prognostication and timely recognition of dying. Recommendations on nutrition and dehydration (avoiding overly aggressive, burdensome or futile treatment) and on dementia stages in relation to care goals (applicability of palliative care) achieved moderate consensus. Conclusion: We have provided the first definition of palliative care in dementia based on evidence and consensus, a framework to provide guidance for clinical practice, policy and research.
Headache as a presenting feature in patients with serotonin syndrome: A case series
Authors: Prakash Sanjay , Belani Pooja , Trivedi Aditi 
Published: July 2013

Introduction Serotonin syndrome (SS) is a drug-induced constellation of various clinical features that result from excess central serotonergic tone. The clinical features range from barely perceptible to life-threatening conditions. Cases We describe four patients with acute headache (four days to three weeks) who were receiving serotonergic drugs for other indications. There was a temporal relation between the administration of the serotonergic drugs and the development of the headaches. All four patients fulfilled the Hunter Serotonin Toxicity Criteria for SS. In parallel, two patients fulfilled the Sternbach’s criteria for SS. Discontinuation of the serotonergic drugs and the administration of cyprohepatadine led to complete improvement in three to seven days in all four patients. Discussion A review of the literature suggests that some overlaps exist in the pathophysiology between SS and headache disorders, including medication-overuse headache. The overlap is also in the management. The drugs found to be effective in SS (cyproheptadine, chlorpromazine, olanzapine, etc.) are also known to have positive effects on some headache disorders. Conclusion Physicians should consider the diagnosis of SS in patients with new onset or worsening headache after the addition of serotonergic drugs, especially in the presence of objective signs on examination suggestive of the disorder such as tremor, fever, hyperreflexia, diaphoresis or tachycardia.
Platelet-rich plasma combined with agarose as a bioactive scaffold to enhance cartilage repair: An in vitro study
Authors: Yin Zhaowei , Yang Xiaofei , Jiang Yiqiu , Xing Linzi , Xu Yang , Lu Yiming , Ding Peng , Ma Junxin , Xu Yan , Gui Jianchao 
Published: July 2013

Objective The purpose of this study was to determine whether the platelet-rich plasma–agarose gel scaffold could be a bioactive scaffold capable of growth factors release for cartilage repair. Methods Porcine chondrocytes were seeded in agarose gel and platelet-rich plasma–agarose gel. During the 28-days culture, microstructure of hydrogels and morphologies of chondrocytes seeded in the hydrogels were observed using scanning electron microscope; viability of chondrocytes in gels was examined by live/dead assay; qualitative and quantitative analysis of glycosaminoglycan, collagen and DNA were assessed by histological, immunohistochemcial staining and biochemical assay; gene expression was measured by real-time polymerase chain reaction. In vitro cartilage ring models were used to evaluate the integration of the scaffolds, and the integration strength was analyzed by mechanical push-out tests. Results Scanning electron microscope revealed both scaffolds had highly uniform porous structure. Live/dead scaffolds showed 100% cells alive in both groups. After 28-days culture, glycosaminoglycan, collagen, DNA content and chondrocyte-related genes expression in platelet-rich plasma–agarose gel were significantly higher than pure agarose gel. Integration strength in platelet-rich plasma–agarose gel was also higher compared to pure agarose gel. Conclusion Platelet-rich plasma showed a positive effect on chondrocytes proliferation, differentiation and integration between native cartilage and engineered tissue when combined with agarose gel. Our findings suggest that platelet-rich plasma–agarose gel scaffold is a promising bioactive scaffold for future cartilage tissue engineering and future clinical works.
Genital streptococcal infection in non-pregnant women: a case-note review
Authors: Sonnex C 
Published: July 2013

Summary The purpose of this case-note review was to examine the clinical features and management of women with either vulval or vaginal swabs culturing positive for streptococci. Group B haemolytic streptococcus was isolated in all cases. The majority of women with vulval streptococci presented with irritation or soreness. Candidal infection was found in 43% and a dermatosis in 27%. All women with positive vaginal culture had vaginal soreness and/or discharge. Candida was isolated in 27% and there were features of desquamative vaginitis in 20%. Women treated with erythromycin failed to improve symptomatically. The findings of this study suggest that streptococci mostly play a secondary role and colonize an already damaged genital epithelium.
Correlates of consistent condom use among female entertainment workers in Shanghai, China: a repeated measures analysis
Authors: Yang X , Xia G 
Published: July 2013

Summary Female entertainment workers (FEWs) in China are at increased risk of HIV and other sexually transmitted infections, but correlates of their risky sexual behaviour remain poorly understood. Using data from a series of four surveys, this paper employs repeated measures analysis to identify individual and social correlates of consistent condom use among FEWs in Shanghai. Results reveal that both individual cognitive and social influence factors are statistically significant in their bivariate relationships to consistent condom use with a stable or non-stable partner; only prevention motivation and perceived self-efficacy in condom use remain significant in the multiple regressions. When individual and social correlates are examined together, only peer support for condom use remains a significant and independent correlate of consistent condom use in sex with a non-stable partner. Behavioural intervention is urgently needed and should take a multilevel approach, emphasizing individual prevention motivation and behavioural skills training and promoting peer/social support.
Penile intraepithelial neoplasia: important lessons from a case series
Authors: Zhou J , Howard M , Williams D , Richardson D 
Published: July 2013

Summary Seven men presenting to our genitourinary (GU) medicine clinic over a period of 22 months had a histopathological diagnosis of penile intraepithelial neoplasia (PIN). Median duration of symptoms was eight months (range 2–216 months). Macroscopic appearances were different in all cases. All histology was reviewed locally and at a tertiary centre. Six of seven had severe dysplasia (PIN III). Interestingly, only one individual was HIV-positive and one, who was immunocompetent, had multifocal disease. These cases highlight the importance of a full anogenital examination and early biopsy in patients presenting with atypical or persistent penile lesions.
Achieving rapid reduction of HIV-1 viral load in HIV-positive pregnant women close to term – an obstetric/medical emergency: a review of three cases
Authors: Adeyemo A , Wood C , Govind A 
Published: July 2013

Summary Mother-to-child transmission (MTCT) of HIV infection is now uncommon in the UK and the management of HIV-positive pregnant women is usually relatively straightforward. However, HIV viral load suppression may be difficult to achieve peripartum for women who book very late in pregnancy and those with a poor adherence to antiretroviral therapy (ART). These pregnancies are at a higher risk of MTCT due to high viral load (VL). Therefore, the development of interventions to achieve a rapid reduction of HIV VL is essential. We describe three relevant cases that presented to our unit over a 12-month period and discuss the strategies employed to manage these challenging cases. All babies were born healthy and were HIV proviral DNA-negative at 12 weeks postpartum. No serious adverse events were reported for the mothers or their babies.
ERK1/2 signalling pathway is involved in CD147-mediated gastric cancer cell line SGC7901 proliferation and invasion
Authors: Chen Liping , Pan Yuqin , Gu Ling , Nie Zhenlin , He Bangshun , Song Guoqi , Li Rui , Xu Yeqiong , Gao Tianyi , Wang Shukui 
Published: July 2013

This study aimed to investigate the role of CD147 in the progression of gastric cancer and the signalling pathway involved in CD147-mediated gastric cancer cell line SGC7901 proliferation and invasion. Short hairpin RNA (shRNA) expression vectors targeting CD147 were constructed to silence CD147, and the expression of CD147 was monitored by quantitative realtime reverse transcriptase polymerase chain reaction and Western blot and further confirmed by immunohistochemistry in vivo. Cell proliferation was determined by Cell Counting Kit-8 assay, the activities of matrix metalloproteinase (MMP)-2 and MMP-9 were determined by gelatin zymography, and the invasion of SGC7901 was determined by invasion assay. The phosphorylation and non-phosphorylation of the mitogen-activated protein kinases, extracellular signal-regulated kinase1/2 (ERK1/2), P38 and c-Jun NH2-terminal kinase were examined by Western blot. Additionally, the ERK1/2 inhibitor U0126 were used to confirm the signalling pathway involved in CD147-mediated SGC7901 progression. The BALB/c nude mice were used to study tumour progression in vivo. The results revealed that CD147 silencing inhibited the proliferation and invasion of SGC7901 cells, and down-regulated the activities of MMP-2 and MMP-9 and the phosphorylation of the ERK1/2 in SGC7901 cells. ERK1/2 inhibitor U0126 decreased the proliferation, and invasion of SGC7901 cells, and down-regulated the MMP-2 and MMP-9 activities. In a nude mouse model of subcutaneous xenografts, the tumour volume was significantly smaller in the SGC7901/shRNA group compared to the SGC7901 and SGC7901/snc-RNA group. Immunohistochemistry analysis showed that CD147 and p-ERK1/2 protein expressions were down-regulated in the SGC7901/shRNA2 group compared to the SGC7901 and SGC7901/snc-RNA group. These results suggest that ERK1/2 pathway involves in CD147-mediated gastric cancer growth and invasion. These findings further highlight the importance of CD147 in cancer progression, indicating that CD147 would be an attractive therapeutic target for gastric cancer.