bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Performance of Benzothieno[3,2‐b]thiophene (BTT)‐Based Bottom‐Contact Thin‐Film Transistors
Authors: Huang Peng‐Yi , Chen Liang‐Hsiang , Chen Yu‐Yuan , Chang Wen‐Jung , Wang Juin‐Jie , Lii Kwang‐Hwa , Yan Jing‐Yi , Ho Jia‐Chong , Lee Cheng‐Chung , Kim Choongik , Chen Ming‐Chou 
Published: January 2013

AbstractThree new benzothieno[3,2‐b]thiophene (BTT; 1) derivatives, which were end‐functionalized with phenyl (BTT‐P; 2), benzothiophenyl (BTT‐BT; 3), and benzothieno[3,2‐b]thiophenyl groups (BBTT; 4; dimer of 1), were synthesized and characterized in organic thin‐film transistors (OTFTs). A new and improved synthetic method for BTTs was developed, which enabled the efficient realization of new BTT‐based semiconductors. The crystal structure of BBTT was determined by single‐crystal X‐ray diffraction. Within this family, BBTT, which had the largest conjugation of the BTT derivatives in this study, exhibited the highest p‐channel characteristic, with a carrier mobility as high as 0.22 cm2 V−1 s−1 and a current on/off ratio of 1×107, as well as good ambient stability for bottom‐contact/bottom‐gate OTFT devices. The device characteristics were correlated with the film morphologies and microstructures of the corresponding compounds.
Variable selection and estimation for multivariate panel count data via the seamless‐${\it L}_{{\rm 0}}$ penalty
Authors: Zhang Haixiang , Sun Jianguo , Wang Dehui 
Published: January 2013

AbstractThis paper considers regression analysis of multivariate panel count data with the focus on variable selection and estimation of significant covariate effects. For the problem, we adopt the penalized estimating equation approach with a focus on the use of the seamless‐$L_0$ penalty. The proposed approach selects variables and estimates regression coefficients simultaneously and the asymptotic properties of the resulting estimates are established. The procedure can be easily carried out with the Newton–Raphson algorithm and is evaluated by simulation studies. Also it is applied to a motivating data set arising from a skin cancer study. The Canadian Journal of Statistics 41: 368–385; 2013 © 2013 Statistical Society of Canada
Comparison of age at natural menopause in BRCA1/2 mutation carriers with a non–clinic‐based sample of women in northern California
Authors: Lin Wayne T. , Beattie Mary , Chen Lee‐may , Oktay Kutluk , Crawford Sybil L. , Gold Ellen B. , Cedars Marcelle , Rosen Mitchell 
Published: January 2013

AbstractBACKGROUND:Germline mutations in BRCA1 and BRCA2 (BRCA1/2) are related to an increased lifetime risk of developing breast and ovarian cancer. Although risk‐reducing salpingo‐oophorectomy reduces the risk of both cancers, loss of fertility is a major concern. A recent study suggested an association between BRCA1 mutation and occult primary ovarian insufficiency. The objective of the current study was to determine whether BRCA1/2 mutation carriers have an earlier onset of natural menopause compared with unaffected women.METHODS:White carriers of the BRCA1/2 gene (n = 382) were identified within the Breast Cancer Risk Program Registry at the University of California at San Francisco and compared with non–clinic‐based white women in northern California (n = 765). The 2 groups were compared with regard to median age at the time of natural menopause before and after adjustment for known risk factors, and the role of smoking within each group was examined using the Kaplan‐Meier approach for unadjusted analyses and Cox proportional hazards regression analyses for adjusted analyses.RESULTS:The median age at the time of natural menopause in the BRCA1/2 carriers was significantly younger than among the unaffected sample (50 years vs 53 years; P < .001). The unadjusted hazard ratio for natural menopause when comparing BRCA1/2 carriers with unaffected women was 4.06 (95% confidence interval, 3.03‐5.45) and was 3.98 (95% confidence interval, 2.87‐5.53) after adjusting for smoking, parity, and oral contraceptive use. For BRCA1/2 carriers who were current heavy smokers (smoking ≥ 20 cigarettes/day), the median age at natural menopause was 46 years versus 49 years for nonsmokers (P = .027).CONCLUSIONS:The BRCA1/2 mutation was associated with a significantly earlier age at natural menopause, and heavy smoking compounded this risk. Because the relationship between menopause and the end of natural fertility is considered to be fixed, these findings suggest the risk of earlier infertility among BRCA1/2 carriers. Cancer 2013. © 2012 American Cancer Society.
Pericardial fluid cytology: An analysis of 128 specimens over a 6‐year period
Authors: Dragoescu Ema A. , Liu Lina 
Published: January 2013

BACKGROUNDPericardial fluid (PF) accumulates through various mechanisms and cytology is part of the workup to determine the specific etiology, primarily to rule in or rule out malignancy. To the best of the authors' knowledge, the current study is the largest systematic evaluation of PF cytology performed to date.METHODSPF specimens collected over 6 years were retrieved. Clinical history, laboratory, cytologic, and pericardial biopsy results were recorded.RESULTSA total of 128 PF specimens were obtained from 113 patients (56 males and 57 females), representing 4.5% of all fluids. Of these, 95 cases (74.2%) were benign, 2 (1.6%) had “severely atypical cells, ” and 31 cases (24.2%) were malignant. The most common etiologies for benign PF specimens were neoplasm (23.1%), idiopathic (19%), infection (14.7%), and connective tissue disease (12.6%). The most common neoplasm producing malignant PF was lung carcinoma, both in males (75%) and females (52.2%), with adenocarcinoma being the most common type (72.2%). In females, breast carcinoma was the second most common neoplasm (39.1%). Approximately 87.1% of patients with malignant PF specimens had a prior history of malignancy and approximately 32.7% underwent a concomitant pericardial biopsy. The false‐negative rate for cytology was 14.7% (hematologic malignancies [2 cases], metastatic sarcoma [1 case], and sarcoidosis [1 case] not detected) and that for pericardial biopsy was 40% (metastatic carcinoma [4 cases] not detected).CONCLUSIONSPF specimens are uncommon. A specific interpretation is rendered in approximately 98.4% of cases. Lung carcinoma is the most common tumor to produce malignant PF in both males and females. Approximately 87.1% of patients with malignant PF have a known history of malignancy. Although cytology is superior to pericardial biopsy in diagnosing metastatic carcinoma, other tumors may go undetected in the PF. Cancer (Cancer Cytopathol) 2013;121:242–51. © 2013 American Cancer Society.
EZH2 and CD79B mutational status over time in B‐cell non‐Hodgkin lymphomas detected by high‐throughput sequencing using minimal samples
Authors: Saieg Mauro Ajaj , Geddie William R. , Boerner Scott L. , Bailey Denis , Crump Michael , da Cunha Santos Gilda 
Published: January 2013

BACKGROUNDNumerous genomic abnormalities in B‐cell non‐Hodgkin lymphomas (NHLs) have been revealed by novel high‐throughput technologies, including recurrent mutations in EZH2 (enhancer of zeste homolog 2) and CD79B (B cell antigen receptor complex‐associated protein beta chain) genes. This study sought to determine the evolution of the mutational status of EZH2 and CD79B over time in different samples from the same patient in a cohort of B‐cell NHLs, through use of a customized multiplex mutation assay.METHODSDNA that was extracted from cytological material stored on FTA cards as well as from additional specimens, including archived frozen and formalin‐fixed histological specimens, archived stained smears, and cytospin preparations, were submitted to a multiplex mutation assay specifically designed for the detection of point mutations involving EZH2 and CD79B, using MassARRAY spectrometry followed by Sanger sequencing.RESULTSAll 121 samples from 80 B‐cell NHL cases were successfully analyzed. Mutations in EZH2 (Y646) and CD79B (Y196) were detected in 13.2% and 8% of the samples, respectively, almost exclusively in follicular lymphomas and diffuse large B‐cell lymphomas. In one‐third of the positive cases, a wild type was detected in a different sample from the same patient during follow‐up.CONCLUSIONSTesting multiple minimal tissue samples using a high‐throughput multiplex platform exponentially increases tissue availability for molecular analysis and might facilitate future studies of tumor progression and the related molecular events. Mutational status of EZH2 and CD79B may vary in B‐cell NHL samples over time and support the concept that individualized therapy should be based on molecular findings at the time of treatment, rather than on results obtained from previous specimens. Cancer (Cancer Cytopathol) 2013;121:377–386. © 2013 American Cancer Society.
ON cone bipolar cell axonal synapses in the OFF inner plexiform layer of the rabbit retina
Authors: Lauritzen J. Scott , Anderson James R. , Jones Bryan W. , Watt Carl B. , Mohammed Shoeb , Hoang John V. , Marc Robert E. 
Published: January 2013

AbstractAnalysis of the rabbit retinal connectome RC1 reveals that the division between the ON and the OFF inner plexiform layer (IPL) is not structurally absolute. ON cone bipolar cells make noncanonical axonal synapses onto specific targets and receive amacrine cell synapses in the nominal OFF layer, creating novel motifs, including inhibitory crossover networks. Automated transmission electron microscopic imaging, molecular tagging, tracing, and rendering of ∼400 bipolar cells reveals axonal ribbons in 36% of ON cone bipolar cells, throughout the OFF IPL. The targets include γ‐aminobutyrate (GABA)‐positive amacrine cells (γACs), glycine‐positive amacrine cells (GACs), and ganglion cells. Most ON cone bipolar cell axonal contacts target GACs driven by OFF cone bipolar cells, forming new architectures for generating ON–OFF amacrine cells. Many of these ON–OFF GACs target ON cone bipolar cell axons, ON γACs, and/or ON–OFF ganglion cells, representing widespread mechanisms for OFF to ON crossover inhibition. Other targets include OFF γACs presynaptic to OFF bipolar cells, forming γAC‐mediated crossover motifs. ON cone bipolar cell axonal ribbons drive bistratified ON–OFF ganglion cells in the OFF layer and provide ON drive to polarity‐appropriate targets such as bistratified diving ganglion cells (bsdGCs). The targeting precision of ON cone bipolar cell axonal synapses shows that this drive incidence is necessarily a joint distribution of cone bipolar cell axonal frequency and target cell trajectories through a given volume of the OFF layer. Such joint distribution sampling is likely common when targets are sparser than sources and when sources are coupled, as are ON cone bipolar cells. J. Comp. Neurol. 521:977–1000, 2013. © 2012 Wiley Periodicals, Inc.
BSNet: a network‐based framework for service‐oriented business ecosystem management
Authors: Huang Keman , Fan Yushun , Tan Wei , Qian Minghui 
Published: January 2013

SUMMARYAs enterprises turning to SOA, services‐oriented business ecosystem (SOBE) has become an important pattern for the organization and management of the massive business services. At the same time, the emergence of Internet of Services (IOS) provides a business model in which service vendors and consumers can interact with each other via the Internet. This paradigm makes it possible that the services in SOBE are managed in an autonomous and coordinated manner. The challenge here is to organize these massive business services, coordinate, and federate them to achieve the benefits of SOA. To address these challenges, this paper presents BSNet, a framework on the basis of the service correlation networks to manage the SOBE. The model consists of a who‐what‐how service correlation network that captures the various relations in SOBE. Finally, a prototype system is developed, and a simulated case study is provided to show the expanded value of our network‐based framework. Copyright © 2013 John Wiley & Sons, Ltd.
ipcmd: a command‐line interface to System V semaphores and message queues
Authors: Weeks Nathan T. , Kraeva Marina , Luecke Glenn R. 
Published: January 2013

SUMMARYConcurrent programming has become a common means to harness the potential performance of multi‐core processors. System V (SysV) message queues and semaphores have been used since the mid 1970s to implement inter‐process concurrency, but they are difficult to use, and bindings exist for few programming languages. This paper introduces ipcmd, a high‐level command‐line interface to SysV message queues and semaphores. ipcmd provides an easy‐to‐use interface for synchronizing concurrent processes to allow application developers to efficiently prototype, debug, and test the use of SysV semaphores and message queues in applications. Easy‐to‐understand applications of semaphores are illustrated using simple shell scripts. Copyright © 2013 John Wiley & Sons, Ltd.
Synthesis of β‐Substituted Porphyrin Derivatives Containing Heterocyclic Moieties as Potential Photosensitizers Against Cutaneous Leishmaniasis
Authors: Bastos Mônica M. , Gomes Ana T. P. C. , Neves Maria G. P. M. S. , Silva Artur M. S. , Santos‐Filho Osvaldo A. , Boechat Núbia , Cavaleiro José A. S. 
Published: January 2013

AbstractThis work reports the synthesis of porphyrin derivatives with potential leishmanicidal activity. The β‐substituents contain amine/imine‐heterocyclic features. Molecular docking simulations of these compounds to a model of the enzyme arginase from Leishmania amazonensis were carried out. Singlet oxygen generation studies have been also considered. The obtained leishmanicidal properties show that these compounds can be considered as prototypes for future cutaneous antileishmaniasis agents.
Studies on the Regioselectivity of the Cyclization of Tryptophanol‐Derived Oxazolopiperidone Lactams
Authors: Amat Mercedes , Llor Núria , Subrizi Fabiana , Pérez Maria , Molins Elies , Bosch Joan 
Published: January 2013

AbstractCyclization of the lactam carbonyl on the indole ring in tryptophanol‐derived oxazolopiperidone lactams 2 and 6, under the classical POCl3‐promoted Bischler–Napieralski conditions and under neutral conditions via the corresponding thiolactam, has been studied. Whereas tricyclic lactam 2 only leads to products coming from an α‐amidoalkylation process, bicyclic lactam 6 undergoes cyclization on the lactam carbonyl, leading to the expected indolo[2,3‐a]quinolizidine derivatives.
Low nM Detection Limits at Porous 1–3 nm Thick Membrane‐Coated Nanostructured Microdisk Electrodes
Authors: Boateng Abraham , Irague Florian , Brajter‐Toth Anna 
Published: January 2013

AbstractLow (15 nM) limits of detection (LOD) of dopamine were obtained at porous 1–3 nm‐thick overoxidized polypyrrole (OPPY) membrane‐coated microdisk carbon fiber electrodes of small size (r=3.5 µm). The excellent mass transport through the porous OPPY membrane (efficiency as good as solution transport) contributes to the low LOD, together with dopamine preconcentration in the membrane. Structural characterization of the membrane coated electrodes confirms the contribution of membrane nanostructure to the high sensitivity and the low LOD.
Simulating wetland impacts on stream flow in southern Africa using a monthly hydrological model
Authors: Hughes Denis A. , Tshimanga Raphael M. , Tirivarombo Sithabile , Tanner Jane 
Published: January 2013

AbstractThe processes that occur in wetlands and natural lakes are often overlooked and not fully incorporated in the conceptual development of many hydrological models of basin runoff. These processes can exert a considerable influence on downstream flow regimes and are critical in understanding the general patterns of runoff generation at the basin scale. This is certainly the case for many river basins of southern Africa which contain large wetlands and natural lakes and for which downstream flow regimes are altered through attenuation, storage and slow release processes that occur within the water bodies. Initial hydrological modelling studies conducted in some of these areas identified the need to explicitly account for wetland storage processes in the conceptual development of models. This study presents an attempt to incorporate wetland processes into an existing hydrological model, with the aim of reducing model structural uncertainties and improving model simulations where the impacts of wetlands or natural lakes on stream flow are evident. The approach is based on relatively flexible functions that account for the input–storage–output relationships between the river channel and the wetland. The simulation results suggest that incorporating lake and wetland storage processes into modelling can provide improved representation (the right results for the right reason) of the hydrological behaviour of some large river basins, as well as reducing some of the uncertainties in the quantification of the original model parameters used for generating the basin runoff. Copyright © 2013 John Wiley & Sons, Ltd.
Wear measurement of highly cross‐linked UHMWPE using a 7Be tracer implantation technique
Authors: Wimmer Markus A. , Laurent Michel P. , Dwiwedi Yasha , Gallardo Luis A. , Chipps Kelly A. , Blackmon Jeffery C. , Kozub Raymond L. , Bardayan Daniel W. , Gross Carl J. , Stracener Daniel W. , Smith Michael S. , Nesaraja Caroline D. , Erikson Luke , Patel Nidhi , Rehm Karl E. , Ahmad Irshad , Greene John P. , Greife Uwe 
Published: January 2013

AbstractThe very low wear rates achieved with the current highly cross‐linked ultrahigh molecular weight polyethylenes (UHMWPE) used in joint prostheses have proven to be difficult to measure accurately by gravimetry. Tracer methods are therefore being explored. The purpose of this study was to perform a proof‐of‐concept experiment on the use of the radioactive tracer beryllium‐7 (7Be) for the determination of in vitro wear in a highly cross‐linked orthopedic UHMWPE. Three cross‐linked and four conventional UHMWPE pins made from compression‐molded GUR 1050, were activated with 109 to 1010
7Be nuclei using a new implantation setup that produced a homogenous distribution of implanted nuclei up to 8.5 μm below the surface. The pins were tested for wear in a six‐station pin‐on‐flat apparatus for up to 7.1 million cycles (178 km). A Germanium gamma detector was employed to determine activity loss of the UHMWPE pins at preset intervals during the wear test. The wear of the cross‐linked UHMWPE pins was readily detected and estimated to be 17 ± 3 μg per million cycles. The conventional‐to‐cross‐linked ratio of the wear rates was 13.1 ± 0.8, in the expected range for these materials. Oxidative degradation damage from implantation was negligible; however, a weak dependence of wear on implantation dose was observed limiting the number of radioactive tracer atoms that can be introduced. Future applications of this tracer technology may include the analysis of location‐specific wear, such as loss of material in the post or backside of a tibial insert. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 423–429, 2013.
Root canal hydrophobization by dentinal silanization: Improvement of silicon‐based endodontic treatment tightness
Authors: Collart Dutilleul Pierre‐Yves , Fonseca Cesar Gaitán , Zimányi László , Romieu Olivier , Pozos‐Guillén Amaury J. , Semetey Vincent , Cuisinier Frédéric , Pérez Elías , Levallois Bernard 
Published: January 2013

AbstractA new strategy to improve silicon‐based endodontic treatment tightness by dentine hydrophobization is presented in this work: root dentine was silanized to obtain a hydrophobic dentine‐sealer interface that limits fluid penetration. This strategy was based on the grafting of aliphatic carbon chains on the dentine through a silanization with the silane end groups [octadecyltrichlorosilane (OTS) and octadecyltriethoxysilane]. Dentine surface was previously pretreated, applying ethylenediaminetetraacetic acid and sodium hypochlorite, to expose hydroxyl groups of collagen for the silane grafting. Collagen fibers exposure after pretreatment was visible with scanning electron microscopy, and Fourier transform infrared (FTIR) spectroscopy showed their correct exposition for the silanization (amide I and II, with 1630, 1580, and 1538 cm‐1 peaks corresponding to the vibration of CO and CN bonds). The grafting of aliphatic carbon chains was confirmed by FTIR (peaks at 2952 and 2923 cm‐1 corresponding to the stretching of CH bonds) and by the increasing of the water contact angle. The most efficient hydrophobization was obtained with OTS in ethyl acetate, with a water contact angle turning from 51° to 109°. Gas and liquid permeability tests showed an increased seal tightness after silanization: the mean gas and water flows dropped from 2.02 × 10‐8 to 1.62 × 10−8 mol s‐1 and from 10.8 × 10−3 to 5.4 × 10−3 µL min−1, respectively. These results show clear evidences to turn hydrophilic dentine surface into a hydrophobic surface that may improve endodontic sealing. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.
Improvement of adhesive strength of segmented polyurethane on Ti–29Nb–13Ta–4.6Zr alloy through H2O2 treatment for biomedical applications
Authors: Hieda Junko , Niinomi Mitsuo , Nakai Masaaki , Kamura Hiroyuki , Tsutsumi Harumi , Hanawa Takao 
Published: January 2013

AbstractThe number of hydroxyl groups on a Ti–29Nb–13Ta–4.6Zr (TNTZ) alloy surface was controlled through H2O2 treatment for further improvement of the adhesive strength and durability against water of TNTZ/silane layers (SILs)/segmented polyurethane (SPU) composites. The effect of the terminal functional groups on the adhesive strength of SPU on TNTZ, and the adhesiveness of SPU on TNTZ against water was investigated. Three types of silane‐coupling agents were used to bind TNTZ and SPU: methacryloxypropyltrimethoxysilane (γ‐MPTS), aminopropyltriethoxysilane (APS), and mercaptopropyltrimethoxysilane (γ‐MPS). The adhesive strength of each composite was evaluated by shear bonding tests. The number of hydroxyl groups increases with an increase in treatment time at a H2O2 concentration of 5% (v/v). On the other hand, an increase from 5% (v/v) to 30% (v/v) in H2O2 concentration leads to a decrease in the number of hydroxyl groups on the TNTZ surface because at higher H2O2 concentrations, the reaction that consumes the hydroxyl groups is dominant. The shear bonding strength is doubled compared with the untreated TNTZ/SIL/SPU interface. Although the shear bonding strength decreases after immersion in water for 30 days when APS and γ‐MPS are used, TNTZ/γ‐MPTS/SPU composites exhibit good durability to water and maintain an equivalent shear bonding strength before immersion in water. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.