bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of ultrasound-guided radial artery catheterization: a systematic review and meta-analysis of randomized controlled trials
Authors: Gu Wan-Jie , Tie Hong-Tao , Liu Jing-Chen , Zeng Xian-Tao 
Published: May 2014

Abstract
Introduction
Ultrasound guidance has emerged as an adjunct for central vein catheterization in both adults and children. However, the use of ultrasound guidance for radial arterial catheterization has not been well established. We conducted a systematic review and meta-analysis to evaluate the efficacy of ultrasound guidance for radial artery catheterization.

Methods
PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched. Randomized controlled trials (RCTs) comparing ultrasound guidance with other techniques (palpation or Doppler) in adult or pediatric patients requiring radial artery catheterization were included. The primary outcome was first-attempt success.

Results
Seven RCTs enrolling 546 patients met the inclusion criteria, and all the selected trials were considered as at high risk of bias. Ultrasound-guided radial artery catheterization was associated with an increased first-attempt success (relative risk (RR) 1.55, 95% confidence interval (CI) 1.02 to 2.35). There was significant heterogeneity among the studies (I2 = 74%). Ultrasound-guided radial artery catheterization in small children and infants also provided an increased chance for first-attempt success (RR 1.94, 95% CI 1.31 to 2.88). Ultrasound guidance further significantly reduced mean attempts to success (weighted mean difference (WMD) −1.13, 95% CI −1.58 to −0.69), mean time to success (WMD −72.97 seconds, 95% CI −134.41 to −11.52), and incidence of the complication of hematoma (RR 0.17, 95% CI 0.07 to 0.41).

Conclusions
Ultrasound guidance is an effective and safe technique for radial artery catheterization, even in small children and infants. However, the results should be interpreted cautiously due to the heterogeneity among the studies.
Hypovitaminosis D and morbidity in critical illness: is there proof beyond reasonable doubt?
Authors: Venkatesh Bala , Nair Priya 
Published: May 2014

AbstractVitamin D is recognized to have important actions outside its well-recognized role in musculoskeletal health. These include antimicrobial action, anti-inflammatory, and cardio-protective properties. A high prevalence of vitamin D deficiency and its association with adverse clinical outcomes have now been widely documented in observational studies in the critically ill. These studies of association, however, do not necessarily imply causation, as vitamin D deficiency may be merely a marker of higher illness severity and consequently poorer outcomes. This issue can be clarified only by undertaking high-quality randomized controlled trials of vitamin D supplementation in this vulnerable population.
Serum amyloid P: a systemic regulator of the innate immune response
Authors: Cox Nehemiah , Pilling Darrell , Gomer Richard H 
Published: May 2014

ABSTRACTThe pentraxin SAP reduces neutrophil adhesion to ECM proteins, inhibits the differentiation of monocytes into fibrocytes, attenuates profibrotic macrophages, activates the complement pathway, and promotes phagocytosis of cell debris. Together, these effects of SAP regulate key aspects of inflammation and set a threshold for immune cell activation. Here, we present a review of SAP biology with an emphasis on SAP receptor interactions and how the effect of SAP on monocytes and macrophages has been explored to develop this protein as a therapeutic for renal and lung injuries. We also discuss how there remain many unanswered questions about the role of SAP in innate immunity.
DNA polymerase alpha interacts with PrSet7 and mediates H4K20 monomethylation in Drosophila
Authors: Sahashi Ritsuko , Crevel Gilles , Pasko Jaroslaw , Suyari Osamu , Nagai Rika , Saura Mario Martinez , Yamaguchi Masamitsu , Cotterill Sue 
Published: May 2014

In human cells appropriate mono-methylation of histone H4 lysine20 by PrSet7/SET8 is important for the correct transcription of specific genes, and timely progression through the cell cycle. Over-methylation appears to be prevented through the interaction of PrSet7 with PCNA, which targets PrSet7 destruction via the CRL4cdt2 pathway, however the factors involved in positive regulation of its histone methylation remain undefined.
Here we present biochemical and genetic evidence for a previously undocumented interaction between dPrSet7 and DNA polymerase-alpha in Drosophila. Depletion of the polymerase reduces H4K20 mono-methylation suggesting that it is required for the expression of dPrSet7 histone methylation activity. We also show that the interaction between PCNA and PrSet7 is conserved in Drosophila, but is only detectable in chromatin fractions. Consistent with this, S2 cells show a significant loss of chromatin bound dPrSet7 protein as S phase progresses.
Based on these data we suggest that interaction with the DNA polymerase represents an important route for the expression of PrSet7 histone methylase activity, by allowing loading of dPrSet7 onto chromatin or its subsequent activation.
Synthesis of Poly(1,2-phenyleneethynylene-1,2-phenylenevinylene) Bearing Phenol Residues and Forming Ability of the Folded Helical Conformation
Authors: Kaneko Takashi , Togashi Yuta , Teraguchi Masahiro , Aoki Toshiki 
Published: May 2014

Abstract
5,4′-Bis(3,5-di-tert-butyl-4-acetoxyphenyl)-2-ethynyl-2′-iodostilbene was synthesized and polymerized by the Sonogashira reaction to give the corresponding regioregular head-to-tail poly(1,2-phenyleneethynylene-1,2-phenylenevinylene). The polymer was converted to the corresponding hydroxy polymer after complete elimination of the protecting acetyl group by treatment with an alkaline solution. It was found that the folded helical conformation was preferred for the polymer containing the poly(1,2-phenylenevinylene) structure upon addition of methanol to the chloroform solution owing to the solvophobic interaction.
The Ayyubid Orogen: An Ophiolite Obduction-Driven Orogen in the Late Cretaceous of the Neo-Tethyan South Margin
Authors: Şengör A.M. Celâl , Stock Joann 
Published: May 2014

A minimum 5000-km long obduction-driven orogeny of medial to late Cretaceous age is located between Cyrenaica in eastern Libya and Oman. It is herein called the Ayyubid Orogen after the Ayyubid Empire that covered much of its territory. The Ayyubid orogen is distinct from other Alpide orogens and has two main parts: a western, mainly germanotype belt and an eastern mainly alpinotype belt. The germanotype belt formed largely as a result of an aborted obduction, whereas the alpinotype part formed as a result of successful and large-scale obduction events that choked a nascent subduction zone. The mainly germanotype part coincides with Erich Krenkel's Syrian Arc (Syrischer Bogen) and the alpinotype part with Ricou's Peri-Arabian Ophiolitic Crescent (Croissant Ophiolitique péri-Arabe). These belts formed as a consequence of the interaction of one of the now-vanished Tethyan plates and Afro-Arabia. The Africa-Eurasia relative motion has influenced the orogen's evolution, but was not the main causative agent. Similar large and complex obduction-driven orogens similar to the Ayyubids may exist along the Ordovician Newfoundland/Scotland margin of the Caledonides and along the Ordovician European margin of the Uralides.SOMMAIREEntre la Cyrénaïque dans l'est de la Libye et Oman, se trouve un ceinture orogénique d’au moins 5 000 km de longueur créé par obduction au Crétacé moyen et tardif. Nous le nommons ici l’orogène ayyoubide d’après l'empire ayyoubide qui couvrait une grande partie de son territoire. L'orogène ayyoubide qui est distincte des autres orogènes alpides, comporte deux parties principales : une bande occidentale, principalement germanotype, et une bande orientale principalement alpinotype. La bande germanotype s’est formée en grande partie à la suite d'une obduction avortée, tandis que la partie alpinotype s’est formée par des épisodes d’obduction à grande échelle qui ont étranglé une zone de subduction naissante. La partie principalement germanotype coïncide avec l’arc syrien d’Erich Krenkel (Syrischer Bogen), alors que la partie alpinotype correspond au croissant ophiolitique péri-Arabe de Ricou (Croissant ophiolitique péri-Arabe). Ces bandes se sont formées par l'interaction de l'une des plaques de la Téthys, maintenant disparues, avec l’Afro-Arabie. Le mouvement relatif Afrique-Eurasie a influencé l'évolution de l'orogène, mais ça n’a pas été le principal facteur. Des orogènes grandes et complexes résultant de mécanismes d’obduction similaires à l’orogène Ayyoubide peuvent exister le long de la marge des Calédonides de l'Ordovicien de Terre-Neuve/Écosse et le long de la marge européenne des Uralides de l'Ordovicien.
Ode to Field Geology of Williams: Fleur de Lys Nectar Still Fermenting on Belle Isle
Authors: De Wit Maarten J. , Armstrong Richard 
Published: May 2014

Throughout the 1960s, Hank Williams put Newfoundland on the proverbial global map as one of the most complete cross-sections of the Appalachian Orogen, and he became a champion attractor to this unique geological laboratory. By the end of the 1960s, Williams, together with Bob Stevens, had mapped the rocks of Belle Isle in the treacherous waters north of the Long Range Peninsula, and suggested their siliciclastic rocks were equivalent to those of the Fleur de Lys type sections on the Burlington Peninsula some 200 km away across White Bay, and by implication that the underlying Laurentian basement on Belle Isle should have its counterpart there too. New U–Pb geochronology on zircon from two samples of possible basement to the Fleur de Lys Supergroup is presented here. These data verify unequivocally the wisdom of the original suggestions based on dedicated field work. The new data also provide evidence that by the earliest Ordovician (ca. 483 Ma), high pressure-low temperature metamorphism at depths in excess of 30 km occurred in Fleur de Lys Supergroup domains. The tectonic implications of these findings are explored, and from this it emerges that only new mapping integrated with high-resolution geochronology and thermochronology are required, both on Belle Isle and in the Fleur de Lys Supergroup, to advance beyond the standards set by Hank Williams.SOMMAIRETout au long des années 1960, Hank Williams aura mis Terre-Neuve sur la carte mondiale comme étant le lieu de l'une des coupes géologiques les plus complètes de la chaîne de l’orogène des Appalaches, devenant ainsi un attracteur incontournable pour ce laboratoire géologique unique. À la fin des années 1960, Bob Stevens et lui avaient cartographié les rochers de Belle-Isle, dans les eaux traîtresses du nord de la péninsule de Long Range, et proposé que leurs roches siliciclastiques étaient l’équivalent de celles des sections des coupes types Fleur de Lys sur le péninsule Burlington, quelques 200 km au delà des eaux de White Bay, et en conséquence, que le sous-sol des Laurentides sous-jacent à Belle-Isle devrait avoir sa contrepartie là aussi. Une nouvelle datation géochronologique U–Pb sur zircon sur deux échantillons, potentiels du substratum du supergroupe de Fleur de Lys, est présentée ici. Ces données corroborent sans équivoque la sagesse des suggestions originales basées sur un travail de terrain méticuleux. Les nouvelles données fournissent aussi la preuve qu’au tout début de l’Ordovicien (env. 483 Ma), qu’un métamorphisme de haute pression et de basse température a sévi à des profondeurs de plus de 30 kilomètres dans les domaines du supergroupe de Fleur de Lys. Les implications tectoniques de ces résultats sont considérées, et de cela il se dégage que seule une nouvelle cartographie intégrée à une géochronologie et une thermochronologie de haute résolution, tant sur Belle-Isle et dans le supergroupe de Fleur de Lys, pourront permettre d’ajouter aux résultats obtenus par Hank Williams.
Exhibition Reviews
Authors: Franklin Kathryn , Léger Marc James , Fisher Jennifer , Drobnick Jim , Suslau Dzmitry , Parke Elizabeth , Peters Lauren Downing , Humphrey Callie 
Published: May 2014

Abstract
GLAM! THE PERFORMANCE OF STYLE Curated by Darren Pih, exhibited at Tate Liverpool, 8 February–12 May 2013, Schirn Kunsthalle Frankfurt, 14 June–22 September 2013, and Lentos Kunstmuseum Linz, 19 October 2013–2 February 2014.
DAVID TOMAS, CONSIGNED FOR AUCTION Artexte, Montreal, 7 September–26 October 2013; 31 October 2013–11 January 2014
55th VENICE BIENNALE Il Palazzo Enciclopedico, curated by Massimiliano Gioni, along with 88 national pavilions and 47 collateral exhibitions, Venice, 1 June–24 November 2013
ART ON THE UNDERGROUND: CONTEMPORARY ART PROGRAMME ON THE TUBE 15 for 150 and other site-specific projects, various curators led by director Tamsin Dillon, locations throughout the London Underground, June 2013 – ongoing
YANG FUDONG, NEW WOMEN Curated by Noah Cowan and Davide Quadrio, commissioned by the Toronto International Film Festival as part of A Century of Chinese Cinema, TIFF Bell Lightbox, Toronto, 7 June – 11 August 2013
DAVID BOWIE IS Curated by Geoffrey Marsh and Victoria Broackes, organized by the Victoria and Albert Museum, London, 23 March – 11 August 2013. Travelling to the Art Gallery of Ontario, Toronto, 25 September – 27 November 2013, and other locations.
ARTE DE CONTRADICCIONES. POP, REALISMOS Y POLÍTICA. BRASIL-ARGENTINA 1960 Curated by Rodrigo Alonso and Paulo Herkenhoff, Fundación Proa, Buenos Aires, 14 July – 16 September 2012
Activist Photo Spaces: ‘Situation Awareness’ and the Exhibition of the Building Workers Unions
Authors: Rocco Vanessa 
Published: May 2014

Abstract
This article aims to demonstrate how the exhibition form and content created a powerful dialectic in the Exhibition of the Building Workers Unions (Berlin, 1931). Interactive display techniques designed by Herbert Bayer, László Moholy-Nagy and Walter Gropius supported messages advocating the crucial societal and economic role played by construction-sector labour unions. Designed to promote the system of free trade unions in Germany, the show demonstrated the potential effectiveness of photography as an integral part of a didactic system, choreographed into various displays that combined images with dynamic graphics and informative texts. To foster interest in the material, the artists used audience-involving strategies including startling viewpoints, photo-strips mounted on moving laths, and touch stations that would beckon the viewer. Taken together, the techniques constituted one of the boldest inter-war attempts to stimulate viewers through multi-sensory empowerment, and incite collective awareness at a time of immense political stakes.
Hepatitis-B: an Alarming Infectious Condition- How Aware are We???
Authors: Rawat Paridhi , Aeran Himanshu , Agarwal Anubha , Nautiyal Vijay 
Published: May 2014

Background & Objectives:
Infections caused by blood-borne pathogens like HCV, HBV or HCV have emerged as a hurricane for health-care workers. Among them, Hepatitis-B is a leading cause of morbidity & mortality all around the world especially placing health workers at higher occupational risks. Also percutaneous injuries in dental clinic are risk factors for transmission of HBV. Hence a bi-directional relationship exists between dentist & patient regarding transmission of HBV. The present study is designed to evaluate degree of awareness & knowledge about HBV & status of vaccination against it, among the dental students & clinicians.

Methods:
A cross-sectional study was conducted on 279 dental professionals including 41 clinicians, 45 post-graduate students, 80 interns and 113 B.D.S III & IV Yr students by means of a questionnaire. Data was collected & then analyzed in SPSS version-16.

Result:
Our results were noteworthy that nearly 89.6% claimed that hepatitis-b is preventable. Positively, 90.71% subjects were vaccinated against HBV & 62.8% showed positive attitude towards HBV+ patients. However, some alarming findings are that 54.64% didn’t know about post-exposure prophylaxis and 79.84% didn’t have any idea about serum HBV DNA viral load considered safe according to CDC.

Conclusion:
The present study consolidates the urgent need for further spread of knowledge & awareness about Hepatitis-B. We also highlight practice of “Standard Infection Control” measures and strict adherence to tenets of CDC guidelines. Hence the call of the hour is to spread awareness about Hepatitis-B which can turn to be a “mouse or an elephant in dental clinic.”
Prevalence of Eruption of Third Molar Tooth among South Indians and Malaysians
Authors: Ren Calvin Gan Chee , Kumar B. Senthil 
Published: May 2014

Introduction:
In prehistoric humans, when the jaw size permitted space for normal dental development and position in the arches, third molar may have been a vital survival tool. However, as human evolution has progressed, jaw size has been gradually decreasing (Lamarckian Evolution). Hence due to the decrease in size of the jaw bone, it’s been reported that approximately 65% of the human population has at least one impacted third molar, and third molars that do erupt are often malposed in the arches and are consequently difficult to clean and prone for infection.

Aim and Objective:
To study the prevalence of eruption of third molar tooth among South Indians and Malaysians by observing the presence of third molars among them and to analyze the percentage of impacted third molars and congenital absence of third molar teeth among the Indian and Malaysian population.

Materials and Methods:
50 Malaysians and 50 Indians (25 males and 25 females in each population) aged between 17 to 25 years old were examined for the presence or absence of the third molars. To confirm the congenital absence of third molars, Orthopantomograms (OPG) were taken.

Results and Conclusion:
In South Indian Population, it was noted that only 48% of males and 64% of females have congenital absence of third molar, and 52% of males and 36% of females have erupted third molars. 16% of males had partly impacted third molar whereas in case of female it was 28%. Congenital absence of third molars among females was 16% more than in males. More males (36%) had impacted third molars than females (24%). It was also noted that majority of them have their maxillary third molars erupted first before their mandibular third molars. In Malaysian Population, it was noted that only 28% of males and 20% of females had congenital absence of third molars, and 72% of males and 80% of females had erupted third molars. 40% of males had partly impacted third molar whereas in case of female it was 52%. Congenital absence of third molars among males was 8% more than females. More males (32%) had impacted third molars than females (28%). It was also noted that in majority of them their mandibular third molars had erupted before their maxillary third molars. When compared among south Indians and Malaysian population congenital absence and impacted third molars are more common in south Indians, whereas partly impacted third molar is more common among Malaysians.
Longitudinal Study of Growth of Children with Unilateral Cleft Lip and Palate: 2 to 10 Years of Age
Authors: Marques Ilza Lazarini , Nackashi John , Borgo Hilton Coimbra , Martinelli Angela Patrícia Menezes Cardoso , De Souza Luiz , De Cássia Rillo Dutka Jeniffer , Williams William N. , Pegoraro-Krook Maria Inês 
Published: May 2014

Objective To study the growth of children with complete unilateral cleft lip and palate (UCLP) from 2 to 10 years of age and to assess whether growth varied from that of children without UCLP (typical children). Design Physical growth was one of the outcome measures of a National Institutes of Health–sponsored longitudinal, prospective clinical trial conducted by the University of Florida and the University of São Paulo. Setting Hospital of Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC-USP), Bauru, Brazil. Main Outcome Measures Height and weight were prospectively measured for 360 healthy children with UCLP who were nonsyndromic, belonged to median socioeconomic status, and received health care at HRAC-USP. To compare growth of children with UCLP to that of typical children, growth curves for UCLP were developed and compared with World Health Organization curves for 2006 and 2007, which were used as reference for typical children. Third-degree polynomials were used to explain the relationship of length and weight with age. Confidence limits of 95% were used for the mean curve using the statistic Z ~ N (0,1). Results Children with UCLP from 2 to 10 years old presented height and weight growth curves similar to those of typical children for both genders. Conclusion Children with UCLP from 2 to 10 years old presented physical growth similar to that of typical children.
Distinct Clinicopathological Features and Prognosis of Emerging Young-Female Breast Cancer in an East Asian Country: A Nationwide Cancer Registry-Based Study
Authors: Lin Ching-Hung , Chuang Po-Ya , Chiang Chun-Ju , Lu Yen-Shen , Cheng Ann-Lii , Kuo Wen-Hung , Huang Chiun-Sheng , Lai Mei-Shu , You San-Lin , Tang Chao-Hsiun 
Published: May 2014

Abstract

Background.
A rapid surge of young-female breast cancer (YFBC) has been observed in Taiwan and other East Asian countries. We recently reported that these cases of YFBC, in contrast to their Western counterparts, are predominantly luminal A subtype. YFBC in Asia may have distinct clinicopathological features and outcomes.

Methods.
Data collected prospectively by participating hospitals were retrieved from the Taiwan Cancer Database. A total of 15,881 women with newly diagnosed stage I–III breast cancer in 2002–2006 were included. The age at diagnosis was categorized into nine 5-year groups (from &lt;30 years to ≥65 years). Clinicopathological variables and patient disease-free survival (DFS) were compared by age group.

Results.
The rates of stage I, estrogen receptor-positive (ER+), and progesterone receptor-positive breast cancer were higher in the younger patients (&lt;50 years) than in the older patients (≥50 years). Univariate analysis showed that the 40–44 and 45–49 age groups were significantly associated with longer DFS than the other age groups. In the ER+ subgroup, multivariate analysis consistently showed that the 40–44 age group was significantly associated with longer DFS than the other age groups except for the 45–49 age group. In contrast, multivariate analysis of the ER-negative subgroup revealed no significant difference of DFS between the 40–44 age group and other age groups.

Conclusion.
Emerging YFBC in Taiwan is uniquely associated with favorable pathological features and better outcomes and should not be regarded as the mirror image of its Western counterpart.