bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Efficient Syntheses of Substituted (.+‐.)‐3‐Oxoisoindoline‐1‐carbonitriles and Carboxamides Using OSU‐6.
Authors: Nammalwar Baskar , Muddala Nagendra Prasad , Murie Maeghan , Bunce Richard A. 
Published: July 2015

AbstractThe Strecker‐type reaction of o‐formylbenzoic acid (I) with silyl cyanide (III) and benzylic or aliphatic amines catalyzed by OSU‐6, an MCM‐41 type hexagonal mesoporous silica, can be tuned to generate two different products: substituted 3‐oxoisoindoline‐1‐carbonitriles (IV) at 23°C or the corresponding carboxamides (VI) at 78°C.
ChemInform Abstract: 2‐(Methoxycarbonyl)ethyl as a Removable N‐Protecting Group: Synthesis of Indoloisoquinolinones by Pd(II)‐Catalyzed Intramolecular Diamination of Alkynes.
Authors: Ha Tu M. , Yao Bo , Wang Qian , Zhu Jieping 
Published: July 2015

AbstractPd(II)‐catalyzed double cyclization of 1,2‐diarylethynes bearing an N‐methyl‐N‐[2‐(methoxycarbonyl)ethyl]amino and an aminocarbonyl group at the ortho positions of the two aromatic rings afford tetracyclic indoloisoquinolinones in high yields.
ChemInform Abstract: Ruthenium Complex‐Catalyzed Domino Addition/exo‐Cycloisomerization of Propargylic Alcohols and Tosyl Isocyanate to Form Oxazolidinones.
Authors: Li Deng Yuan , Chen Hao Jie , Liu Pei Nian 
Published: July 2015

AbstractA tetradentate nitrogen‐phosphorus ligand is used for the ruthenium‐catalyzed title reaction with high exo‐selectivity.
ChemInform Abstract: A Facile Synthesis and Microtubule‐Destabilizing Properties of 4‐(1H‐Benzo[d]imidazol‐2‐yl)‐furazan‐3‐amines.
Authors: Semenov Victor V. , et al.  
Published: July 2015

AbstractA the great number of the title compounds is prepared in good yields via a novel procedure from aminofurazanyl hydroximoyl chlorides and o‐diaminobenzenes.
ChemInform Abstract: DBU‐Promoted Carboxylative Cyclization of o‐Hydroxy‐ and o‐Acetamidoacetophenone.
Authors: Zhang Wen‐Zhen , Liu Si , Lu Xiao‐Bing 
Published: July 2015

AbstractBiologically important 4‐hydroxy‐2‐H‐chromen‐2‐one and 4‐hydroxy‐2(1H)‐quinolinone are conveniently obtained via the title carboxylative cyclization reaction using carbon dioxide as carboxylating reagent.
ChemInform Abstract: Realized C—H Functionalization of Aryldiazo Compounds via Rhodium Relay Catalysis.
Authors: Qiu Lin , Huang Daorui , Xu Guangyang , Dai Zhenya , Sun Jiangtao 
Published: July 2015

AbstractAn unprecedented C—H functionalization of aryldiazo compounds in the presence of alkynes and a rhodium catalyst allows the synthesis of a wide variety of isoquinoline derivatives.
ChemInform Abstract: 3‐Azidothieno[2,3‐b]pyridine Thermolysis as a Route to Novel peri‐Anellated Heterocyclic Derivatives — Benzo(furo)thieno[2,3,4‐ij]‐2,7‐naphthyridines.
Authors: Vasilin Vladimir K. , Kanishcheva Eugeniya A. , Stroganova Tatyana A. , Krapivin Gennady D. 
Published: July 2015

AbstractVarious title compounds (V) and (IX) are obtained by thermolysis of alkyl(aryl) 3‐azidothieno[2,3‐b]pyridine‐2‐carboxylates containing an aryl or heteroaryl substituent at position C‐4 of the thienopyridine core (IV) and (VIII).
ChemInform Abstract: Rh/Cu‐Catalyzed Multiple C—H, C—C, and C—N Bond Cleavage: Facile Synthesis of Pyrido[2,1‐a]indoles from 1‐(Pyridin‐2‐yl)‐1H‐indoles and γ‐Substituted Propargyl Alcohols.
Authors: Li Ting , Wang Zhen , Zhang Mingliang , Zhang Hui‐Jun , Wen Ting‐Bin 
Published: July 2015

AbstractThe multi—step cascade transformation proceeds with excellent chemoselectivity in one—pot reaction
ChemInform Abstract: Domino [3 + 2 + 1] Heteroannulation for Stereoselective Synthesis of anti‐Pyrazolo[3,4‐d][1,3]oxazines.
Authors: Li Guigen , Jiang Bo , Tu Shu‐Jiang , Hao Wen‐Juan , Fan Wei , Sun Mu‐Yan , Ning Yi 
Published: July 2015

AbstractPolysubstituted anti‐pyrazolo[3,4‐d][1,3]oxazines (III) are efficiently and stereoselectively obtained by three‐component one‐pot domino reaction of arylglyoxals with pyrazol‐5‐amines under mild reaction conditions.
ChemInform Abstract: Intramolecular Sulfonylamidomethylation of 2‐(2‐Naphthyl) and 2‐(1‐Naphthyl)ethanesulfonamides: Synthesis of New Class of Naphthosultams.
Authors: Sasiambarrena Leandro D. , Canepa Alicia S. , Luna Constanza N. , Bravo Rodolfo D. 
Published: July 2015

AbstractThe amberlyst XN‐100 catalyzed reactions of sulfamides (I) and (IV) with trioxane (II) gives access to novel naphthosultams with high regioselectivity.
ChemInform Abstract: Amine—Borane Complexes: Air‐ and Moisture‐Stable Partners for Palladium‐Catalyzed Borylation of Aryl Bromides and Chlorides.
Authors: Guerrand Helene D. S. , Vaultier Michel , Pinet Sandra , Pucheault Mathieu 
Published: July 2015

AbstractAryl halides are borylated using an amine—borane complex, which is generated prior to the addition of the coupling partners by treating BH3·NH(iPr)2 with HCl followed by deprotonation with (iPr)2NH.
ChemInform Abstract: Catalytic and Highly Enantioselective Selenolactonization.
Authors: Niu Wenxue , Yeung Ying‐Yeung 
Published: July 2015

Abstract4‐Aryl, hetaryl, and alkyl pent‐4‐enoic acids are transformed with N‐phenylselenophthalimide as an electrophilic selenium source.
ChemInform Abstract: A Li—Mg—N—H Composite as H2 Storage Material: A Case Study with Mg(NH2)2—4LiH—LiNH2.
Authors: Paik Biswajit , Li Hai‐Wen , Wang Jianhui , Akiba Etsuo 
Published: July 2015

AbstractMechanical activation of a 1:4:1 molar mixture of Mg(NH2)2, LiH, and LiNH2 by ball milling under Ar (400 rpm, 20 h) results in a composite which is further used in dehydrogenation experiments using TG‐DTA (140‐400 °C) with mass spectrometric gas detection.
ChemInform Abstract: Recent Development of Biotin Conjugation in Biological Imaging, Sensing, and Target Delivery
Authors: Ren Wen Xiu , Han Jiyou , Uhm Soojin , Jang Yu Jin , Kang Chulhun , Kim Jong‐Hoon , Kim Jong Seung 
Published: July 2015

AbstractReview: 96 refs.
Effektive Aufbereitung von Müllverbrennungsschlacken mittels Hochspannungsimpulsen
Authors: Dittrich Sebastian , Thome Volker , Seifert Severin , Maier Matthias 
Published: July 2015

AbstractDie vorliegende Untersuchung zeigt, dass mittels gepulster Hochspannungsimpulse eine selektive Aufbereitung von Schlacke aus Müllverbrennungsanlagen möglich ist. Es fallen, neben einem Feinanteil der als Filterrückstand aus dem Prozesswasser gewonnen wird, qualitativ fünf Stoffgruppen an, deren Quantität je nach Zusammensetzung der Schlacke variiert. Neben Glas, Keramik und Schmelzprodukten sind Eisen und NE‐Metalle von großem Interesse in Bezug auf Recycling. Schädliche Schwermetalle reichern sich im Feinanteil an, Chloride und Sulfate werden größtenteils mit dem Prozesswasser ausgewaschen. Somit kann das zu deponierenden Schlackevolumen auf die Hälfte reduziert werden.
Antiproliferative and Antioxidant Activity of Glycoconjugates of Dithiocarbamates and Their Copper(II) and Zinc(II) Complexes
Authors: Turnaturi Rita , Oliveri Valentina , Viale Maurizio , Monticone Massimiliano , Vecchio Graziella 
Published: July 2015

AbstractDithiocarbamates (DTCs) are an interesting class of ligands that have been extensively investigated. These compounds have great potential in the field of inorganic and bioinorganic chemistry. In fact, DTCs have been employed as pesticides, fungicides, antibiotics, and antitumor agents. Their applications seem to be tightly related to their ability to form complexes with several metal ions. In this context, DTC derivatives were synthesized and characterized with NMR spectroscopy, electrospray ionization (ESI) mass spectrometry (MS), and UV/Vis spectroscopy. Their copper(II) and zinc(II) complexes were characterized by using ESI‐MS and UV/Vis spectroscopy. The in vitro cytotoxic and apoptotic activity of DTC derivatives was assessed in human cancer cell lines, also in the presence of metal ions, such as copper(II) and zinc(II). Moreover, their superoxide dismutase (SOD)‐like activity was determined.
In Situ Powder Diffraction Studies of Electrode Materials in Rechargeable Batteries
Authors: Sharma Neeraj , Pang Wei Kong , Guo Zaiping , Peterson Vanessa K. 
Published: July 2015

AbstractThe ability to directly track the charge carrier in a battery as it inserts/extracts from an electrode during charge/discharge provides unparalleled insight for researchers into the working mechanism of the device. This crystallographic–electrochemical information can be used to design new materials or modify electrochemical conditions to improve battery performance characteristics, such as lifetime. Critical to collecting operando data used to obtain such information in situ while a battery functions are X‐ray and neutron diffractometers with sufficient spatial and temporal resolution to capture complex and subtle structural changes. The number of operando battery experiments has dramatically increased in recent years, particularly those involving neutron powder diffraction. Herein, the importance of structure–property relationships to understanding battery function, why in situ experimentation is critical to this, and the types of experiments and electrochemical cells required to obtain such information are described. For each battery type, selected research that showcases the power of in situ and operando diffraction experiments to understand battery function is highlighted and future opportunities for such experiments are discussed. The intention is to encourage researchers to use in situ and operando techniques and to provide a concise overview of this area of research.
Cellulose Dissolution and In Situ Grafting in a Reversible System using an Organocatalyst and Carbon Dioxide
Authors: Song Longchu , Yang Yunlong , Xie Haibo , Liu Enhui 
Published: July 2015

AbstractCellulose is a promising renewable material, but cannot easily be processed homogeneously owing to the stiffness of the molecules and the dense packing of its chains, due to intermolecular hydrogen bonds. Cellulose processability can be improved by chemical modification. The reversible reaction of cellulose with carbon dioxide in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) allows dissolution of cellulose in dimethyl sulfoxide (DMSO). This DMSO solution is an effective medium for grafting l‐lactide (LLA) from cellulose by ring‐opening polymerization (ROP) under mild conditions, allowing to prepare cellulose‐graft‐poly(l‐lactide) co‐polymers with a molar substitution (MSPLLA) of poly(l‐lactide) in the range of 0.37–5.32, at 80 °C. This makes DBU not only an important reagent to achieve cellulose dissolution, but it also acts as organocatalyst for the subsequent ring‐opening polymerization process. Characterization of the structure and thermal properties of the co‐polymers by a variety of techniques reveals that they have a single glass‐transition temperature (Tg), which decreases with increasing MSPLLA. Thus, the modification results in a transformation of the originally semirigid cellulose into a thermoplastic material with tunable Tg. The carbon dioxide dissolution strategy is an efficient platform for cellulose derivatization by homogeneous organocatalysis.
Belief propagation‐based compressed video sensing for mobile Internet
Authors: Tian Fang , Liu Haixiao , Song Bin , Qin Hao , Ren Guangliang 
Published: July 2015

SummaryThe very high data rate applications such as streaming high‐definition video have attracted much attention of researchers in 5G systems. However, the design of 5G communication terminals faces several challenges, including how to reduce the computational burden of signal acquisition at the terminals and how to improve both the reconstruction quality and robust performance in wireless channels. How simple and fast online video acquisition can be implemented and how the original images can be recovered effectively by an offline algorithm for mobile Internet are taken into consideration in this paper. Specially, we firstly propose a Markov chain model to characterize variations of the video sequences' temporal correlation, wherein we utilize the measurement residue that reflects the intensity changes to estimate the transition matrix. Then, a compressed video sensing framework for mobile Internet is presented with the belief propagation algorithm and the proposed video signal model. Numerical results show that our proposal could efficiently utilize the temporal correlation in video and then obtain both the improved reconstruction quality and robust performance in wireless communication systems. Copyright © 2015 John Wiley & Sons, Ltd.
Generation of Evc2/Limbin global and conditional KO mice and its roles during mineralized tissue formation
Authors: Zhang Honghao , Takeda Haruko , Tsuji Takehito , Kamiya Nobuhiro , Rajderkar Sudha , Louie Ke'Ale , Collier Crystal , Scott Greg , Ray Manas , Mochida Yoshiyuki , Kaartinen Vesa , Kunieda Tetsuo , Mishina Yuji 
Published: July 2015

SummaryEllis‐van Creveld (EvC) syndrome (OMIM 225500) is an autosomal recessive disease characterized with chondrodysplastic dwarfism in association with abnormalities in oral cavity. Ciliary proteins EVC and EVC2 have been identified as causative genes and they play an important role on Hedgehog signal transduction. We have also identified a causative gene LIMBIN for bovine chondrodysplastic dwarfism (bcd) that is later identified as the bovine ortholog of EVC2. Here, we report generation of conventional and conditional mutant Evc2/Limbin alleles that mimics mutations found in EvC patients and bcd cattle. Resulted homozygous mice showed no ciliary localization of EVC2 and EVC and displayed reduced Hedgehog signaling activity in association with skeletal and oral defects similar to the EvC patients. Cartilage‐specific disruption of Evc2/Limbin resulted in similar but milder skeletal defects, whereas osteoblast‐specific disruption did not cause overt changes in skeletal system. Neural crest‐specific disruption of Evc2/Limbin resulted in defective incisor growth similar to that seen in conventional knockouts; however, differentiation of amelobolasts was relatively normal in the conditional knockouts. These results showcased functions of EVC2/LIMBIN during formation of mineralized tissues. Availability of the conditional allele for this gene should facilitate further detailed analyses of the role of EVC2/LIMBIN in pathogenesis of EvC syndrome. genesis 53:612–626, 2015. © 2015 Wiley Periodicals, Inc.
Voltammetric Determination of Cocaine Using Carbon Screen Printed Electrodes Chemically Modified with Uranyl Schiff Base Films
Authors: Muzetti Ribeiro Maria Fernanda , da Cruz Júnior José Wilmo , Dockal Edward Ralph , McCord Bruce Royston , de Oliveira Marcelo Firmino 
Published: July 2015

AbstractChemically modified screen printed electrodes (CM‐SPE) using [UO2(4‐MeOSalen)(H2O)] ⋅ H2O films were employed in the voltammetric determination of cocaine. The chemical modification was performed by dip coating electrode surfaces (carbon, gold, and platinum) with methanolic solution containing the Schiff base complex with subsequent drying step at room temperature. The optimized amount of the chemical modifier over the working electrode was found to be 2.39 µg mm−2 (geometric area). The voltammetric measurements were carried out in 50 : 50 v/v methanol:water solution containing 0.05 mol L−1 KCl and 0.1 mol L−1 LiCl as a supporting electrolyte without oxygen elimination by inert gas flow. The best results were obtained with carbon electrodes. Cocaine exhibits a well defined irreversible anodic peak current (ipa) at a potential (Epa) of 0.85 V vs Ag/AgCl. The current is directly proportional to the drug concentration. An optimal accumulation potential (Eprec), and time (tprec) of −0.80 V (vs Ag/AgCl), and 120 s, respectively, were determined. The linear dependence of ipa with square root of scan rate (υ) indicates that the mass transport at the electrode surface is controlled by diffusion. An optimized scan rate of 100 mV s−1 was obtained for analytical purposes. A limit of detection (LOD) and limit of quantification (LOQ) in 110 and 390 µmol L−1, respectively, with intra and inter‐day repeatability of 2.61 % and 3.77 %, respectively, were obtained. In interference studies the proposed method demonstrated high specificity for cocaine in the presence of morphine and 3,4‐methylenedioxymethanphetamine. The above results demonstrate that this method provides a fast and low cost procedure for determination of cocaine in trace levels.
Common neural correlates of emotion perception in humans
Authors: Jastorff Jan , Huang Yun‐An , Giese Martin A. , Vandenbulcke Mathieu 
Published: July 2015

AbstractWhether neuroimaging findings support discriminable neural correlates of emotion categories is a longstanding controversy. Two recent meta‐analyses arrived at opposite conclusions, with one supporting (Vytal and Hamann []: J Cogn Neurosci 22:2864–2885) and the other opposing this proposition (Lindquist et al. []: Behav Brain Sci 35:121–143). To obtain direct evidence regarding this issue, we compared activations for four emotions within a single fMRI design. Angry, happy, fearful, sad and neutral stimuli were presented as dynamic body expressions. In addition, observers categorized motion morphs between neutral and emotional stimuli in a behavioral experiment to determine their relative sensitivities. Brain–behavior correlations revealed a large brain network that was identical for all four tested emotions. This network consisted predominantly of regions located within the default mode network and the salience network. Despite showing brain–behavior correlations for all emotions, muli‐voxel pattern analyses indicated that several nodes of this emotion general network contained information capable of discriminating between individual emotions. However, significant discrimination was not limited to the emotional network, but was also observed in several regions within the action observation network. Taken together, our results favor the position that one common emotional brain network supports the visual processing and discrimination of emotional stimuli. Hum Brain Mapp 36:4184–4201, 2015. © 2015 Wiley Periodicals, Inc.
Dysfunctional amygdala activation and connectivity with the prefrontal cortex in current cocaine users
Authors: Crunelle Cleo L. , Kaag Anne Marije , van den Munkhof Hanna E. , Reneman Liesbeth , Homberg Judith R. , Sabbe Bernard , van den Brink Wim , van Wingen Guido 
Published: July 2015

AbstractObjectivesStimulant use is associated with increased anxiety and a single administration of dexamphetamine increases amygdala activation to biologically salient stimuli in healthy individuals. Here, we investigate how current cocaine use affects amygdala activity and amygdala connectivity with the prefrontal cortex in response to biologically salient stimuli in an emotional face matching task (EFMT).Experimental designAmygdala activity and amygdala connectivity during the EFMT were assessed in 51 cocaine using males and 32 non‐drug‐using healthy males using functional magnetic resonance imaging (fMRI). Within the cocaine use group, we explored whether amygdala activation was associated with age of first use of cocaine and duration of cocaine use to distinguish between amygdala activation alterations as a cause or a consequence of cocaine use.Principal observationsWe observed hyperactivity of the amygdala, thalamus, and hippocampus and reduced amygdala connectivity with the anterior cingulate gyrus in response to angry and fearful facial expressions in current cocaine users compared to controls. Increased amygdala activation was independently associated with earlier age of first cocaine use and with longer exposure to cocaine.ConclusionsOur findings suggest that amygdala hyperactivity to biologically salient stimuli may represent a risk factor for an early onset of cocaine use and that prolonged cocaine use may further sensitize amygdala activation. High amygdala activation to emotional face processing in current cocaine users may result from low prefrontal control of the amygdala response to such stimuli. Hum Brain Mapp 36:4222–4230, 2015. © 2015 Wiley Periodicals, Inc.
Signals of short‐term climatic periodicities detected in the groundwater of North China Plain
Authors: Cao Guoliang , Zheng Chunmiao 
Published: July 2015

AbstractGrowing demand on groundwater resources and the semi‐arid climate in the North China Plain (NCP) highlight the need for improved understanding of connections between regional climate change and groundwater recharge. Hydrologic time series of precipitation and groundwater levels were analyzed in three representative geographical zones throughout the NCP for the period of 1960–2008 using trend analysis and spectral analysis methods. A significant change point around 1975 is followed by a long‐term decline trend in precipitation time series, which coincides with the Pacific Decadal Oscillation positive phase. However, the magnitudes of groundwater level variability due to heavy pumping overwhelm the low‐frequency signal of groundwater levels. Nonlinear trends that related to long‐term climatic variability and anthropogenic activities are removed by using the Singular Spectrum Analysis method. Spectral analyses of the detrended residuals demonstrate significant short‐term oscillations at the frequencies of 2–7 years, which have strong correlations with the El Niño–Southern Oscillation modes. This study contributes to improved understanding of dynamic relationship between groundwater and climate variability modes in the NCP and demonstrates the importance of reliable detrending methods for groundwater levels that are affected greatly by pumping. Copyright © 2015 John Wiley & Sons, Ltd.
Pharmacokinetics of meropenem in children receiving continuous renal replacement therapy: Validation of clinical trial simulations
Authors: Nehus Edward J. , Mizuno Tomoyuki , Cox Shareen , Goldstein Stuart L. , Vinks Alexander A. 
Published: July 2015

AbstractMeropenem is frequently prescribed in critically ill children receiving continuous renal replacement therapy (CRRT). We previously used clinical trial simulations to evaluate dosing regimens of meropenem in this population and reported that a dose of 20 mg/kg every 12 hours optimizes target attainment. Meropenem pharmacokinetics were investigated in this prospective, open‐label study to validate our previous in silico predictions. Seven patients received meropenem (13.8–22 mg/kg) administered intravenously every 12 hours as part of standard care. A mean dose of 18.6 mg/kg of meropenem was administered, resulting in a mean peak concentration of 80.1 μg/mL. Meropenem volume of distribution was 0.35 ± 0.085 L/kg. CRRT clearance was 40.2 ± 6.6 mL/(min · 1.73 m2) and accounted for 63.4% of the total clearance of 74.8 ± 36.9 mL/(min · 1.73 m2). Simulations demonstrated that a dose of 20 mg/kg every 12 hours resulted in a time above the minimum inhibitory concentration (%fT > MIC) of 100% in 5 out of 7 subjects, with a %fT > MIC of 93% and 43% in the remaining 2 subjects. We conclude that CRRT contributed significantly to the total clearance of meropenem. A dosing regimen of 20 mg/kg achieved good target attainment in critically ill children receiving CRRT, which is consistent with our previously published in silico predictions.