bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication of polymer/drug‐loaded hydroxyapatite particle composite fibers for drug sustained release
Authors: Song Botao , Xu Qing , Wang Cuiyu , Xu Shichen , Zhang Hongxin 
Published: September 2015

ABSTRACTThe aim of this study is to fabricate polymer/hydroxyapatite (HA) particle composite fibers for drug encapsulation and sustained release. Firstly, drug‐loaded hydroxyapatite particles are synthesized in one step, then by electrospinning of the blends of drug‐loaded hydroxyapatite particles and polymer solution the drug‐loaded polymer/hydroxyapatite particle composite fibers are successfully prepared. Effect of loading ratio of drug‐loaded hydroxyapatite particles in the fibers and pH value of the release medium on the drug release kinetics are both investigated, and the results demonstrate that, as compared with the polymer/drug electrospun fibers, the drug in the polymer/drug‐loaded hydroxyapatite particle composite fibers shows a sustained release manner, and the drug release rate can be regulated by both the loading ratio of drug‐loaded hydroxyapatite particles in the composite fibers and pH value of the buffer solution. The results indicate that the developed drug‐loaded polymer/hydroxyapatite particle composite fibers show great potential in bone regeneration and other related biomedical fields. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2016,133, 42871.
Conservation of freshwater biodiversity in key areas of the Colombian Amazon
Authors: Portocarrero‐Aya Marcela , Cowx Ian G. 
Published: September 2015

Abstract

Little has been done to identify key conservation areas in the Amazonian freshwater ecosystems of Colombia.
This research constitutes the first attempt to systematically identify important conservation areas in the freshwater ecosystems of the South of the Colombian Amazonian Trapezium. This effort considered not only fine filter targets (species) as central elements of decision making, but coarse filter targets (habitats), ecosystem services and social benefits, and threats. Owing to the complexity of the study area, a multi‐criteria assessment constituted a good approach to tackle the issues affecting a complex ecological, cultural, social, economic and political territory.
Five sites stood out and were considered important as areas for targeted management: the Tarapoto Lakes System, Yahuarcaca Lakes System, Loreto‐Yacu River, and Mocagua Island (Colombia) and Caballo Cocha Lake (Peru). Biodiversity conservation initiatives as well as livelihood improvement projects are currently in motion in the area aiming to find a balance between resource use and local development.
Copyright © 2015 John Wiley & Sons, Ltd.
Enhanced photo‐bioelectrochemical energy conversion by genetically engineered cyanobacteria
Authors: Sekar Narendran , Jain Rachit , Yan Yajun , Ramasamy Ramaraja P. 
Published: September 2015

ABSTRACTPhotosynthetic energy conversion using natural systems is increasingly being investigated in the recent years. Photosynthetic microorganisms, such as cyanobacteria, exhibit light‐dependent electrogenic characteristics in photo‐bioelectrochemical cells (PBEC) that generate substantial photocurrents, yet the current densities are lower than their photovoltaic counterparts. Recently, we demonstrated that a cyanobacterium named Nostoc sp. employed in PBEC could generate up to 35 mW m−2 even in a non‐engineered PBEC. With the insights obtained from our previous research, a novel and successful attempt has been made in the current study to genetically engineer the cyanobacteria to further enhance its extracellular electron transfer. The cyanobacterium Synechococcus elongatus PCC 7942 was genetically engineered to express a non‐native redox protein called outer membrane cytochrome S (OmcS). OmcS is predominantly responsible for metal reducing abilities of exoelectrogens such as Geobacter sp. The engineered S. elongatus exhibited higher extracellular electron transfer ability resulting in approximately ninefold higher photocurrent generation on the anode of a PBEC than the corresponding wild‐type cyanobacterium. This work highlights the scope for enhancing photocurrent generation in cyanobacteria, thereby benefiting faster advancement of the photosynthetic microbial fuel cell technology. Biotechnol. Bioeng. 2016;113: 675–679. © 2015 Wiley Periodicals, Inc.
The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2‐W68G mutation
Authors: O'Connell Susan M. , Proks Peter , Kramer Holger , Mattis Katia K. , Sachse Gregor , Joyce Caroline , Houghton Jayne A. L. , Ellard Sian , Hattersley Andrew T. , Ashcroft Frances M. , O'Riordan Stephen M. P. 
Published: September 2015

Key Clinical MessageIn infants, especially with novel previously undescribed mutations of the KATP channel causing neonatal diabetes, in vitro studies can be used to both predict the response to sulphonylurea treatment and support a second trial of glibenclamide at higher than standard doses if the expected response is not observed.
Aggregation Processes of Perylene Bisimide Diimidazolium Salts
Authors: D'Anna Francesca , Marullo Salvatore , Lazzara Giuseppe , Vitale Paola , Noto Renato 
Published: September 2015

AbstractThe supramolecular aggregation of three diimidazolium‐functionalized perylene bisimides, differing in the alkyl chain length was investigated. These salts form aggregates in solvents like chloroform, dichloromethane, and glycerol. Solvent‐, concentration‐, and temperature‐dependent spectroscopic studies were carried out, evidencing the occurrence of an isodesmic, enthalpy‐driven aggregation process, underpinned by π–π stacking and hydrogen bonding. Moreover, dynamic light scattering (DLS) measurements and SEM images revealed that these salts aggregate in chloroform into elongated structures.
Construction of Cluster Organic Frameworks with bnn Hexagonal BN Topologies
Authors: Fang Wei‐Hui , Zhang Lei , Zhang Jian , Yang Guo‐Yu 
Published: September 2015

AbstractTwo sandwiched cluster organic frameworks, Eu6(OH)2Cu9I6L12(ox)3⋅H2O⋅ClO4 (FJ‐23, HL=4‐pyridin‐ 4‐yl‐benzonic acid, ox=oxalate) and Eu6Cu7I7L12(OAc)6(H2O)2⋅2 H2O (FJ‐24, OAc=acetate) with bnn hexagonal BN topologies have been successfully made; these frameworks were assembled by nanosized graphene‐like lanthanide wheel clusters and nanoscale trigonal prism metalloligands. The cooperation of small equatorial ligands and axially trigonal prism metalloligands plays a key role in the construction of such 5‐connected nets. Furthermore, the thermal stabilities and chiral characteristics were also studied.
Catalytic Asymmetric Construction of α‐Quaternary Cyclopentanones and Its Application to the Syntheses of (−)‐1,14‐Herbertenediol and (−)‐Aphanorphine
Authors: Zhu Dao‐Yong , Xu Ming‐Hui , Tu Yong‐Qiang , Zhang Fu‐Min , Wang Shao‐Hua 
Published: September 2015

AbstractA novel and efficient strategy to build α‐benzylic quaternary cyclopentanones with excellent enantioselectivities (up to 96 % ee) and high yields (up to 99 % yield) has been developed, and its application demonstrated by the first catalytic asymmetric total synthesis of (−)‐1,14‐herbertenediol and the formal synthesis of (−)‐aphanorphine.
Cu‐Catalyzed Alkylative Carboxylation of Ynamides with Dialkylzinc Reagents and Carbon Dioxide
Authors: Takimoto Masanori , Gholap Sandeep Suryabhan , Hou Zhaomin 
Published: September 2015

AbstractAlkylative carboxylation of ynamides with CO2 and dialkylzinc reagents using a N‐heterocyclic carbene (NHC)–copper catalyst has been developed. A variety of ynamides, both cyclic and acyclic, undergo this transformation under mild conditions to afford the corresponding α,β‐unsaturated carboxylic acids, which contain the α,β‐dehydroamino acid skeleton. The present alkylative carboxylation formally consists of Cu‐catalyzed carbozincation of ynamides with dialkylzinc reagents with the subsequent nucleophilic carboxylation of the resulting alkenylzinc species with CO2. Dialkylzinc reagents bearing a β‐hydrogen atom such as Et2Zn and Bu2Zn still afford the alkylated products despite the potential for β‐hydride elimination. This protocol would be a desirable method for the synthesis of highly substituted α,β‐ dehydroamino acid derivatives due to its high regio‐ and stereoselectivity, simple one‐pot procedure, and its use of CO2 as a starting material.
Deciphering Photoluminescence Dynamics and Reactivity of the Luminescent Metal–Metal‐Bonded Excited State of a Binuclear Gold(I) Phosphine Complex Containing Open Coordination Sites
Authors: Ma Chensheng , Chan Chris Tsz‐Leung , To Wai‐Pong , Kwok Wai‐Ming , Che Chi‐Ming 
Published: September 2015

AbstractLuminescent metal complexes having open coordination sites hold promise in the design of sensory materials and photocatalysts. As a prototype example, [Au2(dcpm)2)]2+ (dcpm = bis(dicyclohexylphosphanyl) is known for its intriguing environmental sensitive photoluminescence. By integrating a range of complementary ultrafast time‐resolved spectroscopy to interrogate the excited state dynamics, this study uncovers that the events occurring in extremely rapid timescales and which are modulated strongly by environmental conditions play a pivotal role in the luminescence behavior and photochemical outcomes. Formed independent of the phase and solvent property within ∼0.15 ps, the metal–metal bonded 35dσ*6pσ state is highly reactive possessing strong propensity toward increasing coordination number at AuI center, and with ∼510 ps lifetime in dichloromethane is able to mediate light induced C–X bond cleavage.
Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors
Authors: Shang Hui , Braggio Danielle , Lee Ya‐Jung , Al Sannaa Ghadah A. , Creighton Chad J. , Bolshakov Svetlana , Lazar Alexander J. F. , Lev Dina , Pollock Raphael E. 
Published: September 2015

BACKGROUNDDesmoid tumors (DTs) are rare mesenchymal lesions that can recur repeatedly. When it is feasible, DTs are surgically resected; however, this often results in high recurrence rates. Recently, treatment with PF‐03084014, a potent γ‐secretase inhibitor, has been shown to have antitumor activity in several tumor types by affecting the WNT/β‐catenin pathway. Consequently, Notch pathway inhibition by PF‐03084014 might be a promising approach for DT treatment.METHODSThe expression of Notch pathway components was analyzed in DT tissues and cell strains with immunohistochemistry and Western blotting, respectively. A panel of DT cell strains was exposed to PF‐03084014 and evaluated for cell proliferation. Antitumor effects were assessed via cell cycle, apoptosis, and migration and invasion analysis. Cells treated with PF‐03084014 were characterized with a gene array analysis combined with Ingenuity Pathway Analysis.RESULTSThe results showed that Notch pathway components were expressed at different levels in DTs. Hes1 (Hes Family BHLH Transcription Factor 1) was overexpressed in DT tumors versus dermal scar tissue, and PF‐03084014 caused significant decreases in Notch intracellular domain and Hes1 expression in DT cell strains. PF‐03084014 decreased DT cell migration and invasion and also caused cell growth inhibition in DT cell strains, most likely through cell cycle arrest. Gene array analysis combined with Ingenuity Pathway Analysis showed that Wnt1‐inducible signaling pathway protein 2 possibly regulated Notch and WNT pathways after treatment with PF‐03084014 through integrin.CONCLUSIONOur findings suggest that the Notch pathway is an important DT therapeutic target. Furthermore, PF‐03084014 has significant antitumor activity against DTs, and it may be an alternative strategy for DT treatment. Cancer 2015;121:4088–4096. © 2015 American Cancer Society.
Stereotactic body radiation therapy versus no treatment for early stage non–small cell lung cancer in medically inoperable elderly patients: A National Cancer Data Base analysis
Authors: Nanda Ronica H. , Liu Yuan , Gillespie Theresa W. , Mikell John L. , Ramalingam Suresh S. , Fernandez Felix G. , Curran Walter J. , Lipscomb Joseph , Higgins Kristin A. 
Published: September 2015

BACKGROUNDStereotactic body radiation therapy (SBRT) has demonstrated high rates of local control with low morbidity and has now emerged as the standard of care for medically inoperable, early stage non–small cell lung cancer (NSCLC). However, the impact of lung SBRT on survival in the elderly population is less clear given competing comorbid conditions. An analysis of the National Cancer Data Base (NCDB) was undertaken to determine whether definitive SBRT improves survival relative to observation alone patients ages 70 years and older.METHODSThe NCDB, a retrospective national database that captures approximately 70% of all patients treated for cancer, was queried for patients aged 70 years or older with early stage (T1‐T3N0M0) NSCLC from 2003 to 2006. Overall survival was compared between patients who received stereotactic body radiotherapy alone and those who received no treatment. An extended Cox proportional hazards model was applied to estimate the treatment effect of SBRT.RESULTSIn total, 3147 patients met the selection criteria for this analysis. SBRT was delivered to 258 patients (8.2%), and 2889 patients (91.8%) received no treatment. There was no significant difference in the distribution of Charlson/Deyo comorbidity index scores between the 2 groups (P = .076). Multivariable analysis revealed improved overall survival with SBRT compared with observation for the entire cohort (hazard ratio, 0.64; P < .001).CONCLUSIONSSBRT is associated with improved survival in elderly patients with early stage NSCLC who have concurrent comorbid conditions compared with observation alone. The current data support the use of SBRT for the treatment of elderly patients with early stage NSCLC who have limiting comorbid conditions. Cancer 2015;121:4222–4230. © 2015 American Cancer Society.
Feasibility, acceptability, and preliminary efficacy of a technology‐assisted psychosocial intervention for racially diverse men with advanced prostate cancer
Authors: Yanez Betina , McGinty Heather L. , Mohr David C. , Begale Mark J. , Dahn Jason R. , Flury Sarah C. , Perry Kent T. , Penedo Frank J. 
Published: September 2015

BACKGROUNDThe utility of psychosocial interventions in reducing symptom burden and improving health‐related quality of life (HRQOL) for men with localized prostate cancer has been demonstrated. However, studies have yet to demonstrate the efficacy of interventions in advanced prostate cancer (APC). This study examined the feasibility, acceptability, and preliminary efficacy of a technology‐assisted, 10‐week, group‐based psychosocial intervention for diverse men with APC.METHODSThe participants were 74 men (mean age, 68.84 years; non‐Hispanic white, 57%; black, 40.5%) who were randomized to a cognitive‐behavioral stress management (CBSM) treatment or health promotion (HP) attention‐control condition. The participants were assessed at the baseline, weekly throughout the 10‐week program, and 6 months after the baseline. Outcomes were assessed with the Patient‐Reported Outcomes Measurement Information System along with established measures of HRQOL, CBSM intervention targets (eg, relaxation skills), and patient‐reported acceptability.RESULTSFeasibility was demonstrated through good retention rates (>85%) and acceptable average attendance rates (>70%), and acceptability was demonstrated through very favorable weekly session evaluations (mean score, 4/5) and exit surveys (mean score, 3.6/4). Men randomized to the CBSM condition reported significant reductions (P < .05) in depressive symptoms and improvements in relaxation self‐efficacy (P < .05) at the 6‐month follow‐up. CBSM participants reported trends for improvement in distress and functional well‐being (P < .08) in comparison with those in the HP condition. Effect sizes ranged from medium (0.54) to large (1.87) and, in some instances, were clinically meaningful.CONCLUSIONSTechnology‐based CBSM interventions among diverse men with APC may be feasible, acceptable, and efficacious. Cancer 2015;121:4407–15. © 2015 American Cancer Society.
Adolescents' preferences for treatment decisional involvement during their cancer
Authors: Weaver Meaghann S. , Baker Justin N. , Gattuso Jami S. , Gibson Deborah V. , Sykes April D. , Hinds Pamela S. 
Published: September 2015

BACKGROUNDThis qualitative study investigated the medical decision‐making preferences of adolescent oncology patients and the parental and clinician behaviors that adolescents report to be supportive of their preferred level of decision‐making involvement.METHODSInterviews were conducted with 40 adolescents between the ages of 12 and 18 years who were undergoing cancer treatment in Memphis, Tenn or Washington, DC. Role preferences were converted into a predetermined Likert scale decisional preference score. A semantic content analysis was used to analyze patient reports of parental behaviors, attitudes, knowledge levels, and relational interactions that facilitated their preferred level of involvement in decision making. Clinician behaviors described as supportive of decisional processes were also categorized thematically. A teen advisory council validated study findings. Data reporting followed strict adherence to Consolidated Criteria for Reporting Qualitative Research guidelines.RESULTSAdolescents indicated a spectrum of preferred decisional roles, with the most common being an actively involved role (26 of 40 or 65%), although a shared decision‐making approach was still valued. There was no statistically significant difference in the preferred decisional role with respect to demographic or medical characteristics, including the relapse status, although adolescents who preferred autonomous interview settings were more likely to prefer active decisional roles (P < .001). Adolescents recognized that situational and social contexts might shift their preferred level of involvement in medical decisions. Although adolescents wanted to be involved in decisions, they also expressed an appreciation of family insight, parental presence, and clinician guidance.CONCLUSIONSAdolescents with cancer are able to retrospectively identify their preferences for inclusion in medical decision making, and even when preferring involvement, they value the input of trusted others. Cancer 2015;121:4416–24. © 2015 American Cancer Society.
Prognosis for patients with metastatic breast cancer who achieve a no‐evidence‐of‐disease status after systemic or local therapy
Authors: Bishop Andrew J. , Ensor Joe , Moulder Stacy L. , Shaitelman Simona F. , Edson Mark A. , Whitman Gary J. , Bishnoi Sandra , Hoffman Karen E. , Stauder Michael C. , Valero Vicente , Buchholz Thomas A. , Ueno Naoto T. , Babiera Gildy , Woodward Wendy A. 
Published: September 2015

BACKGROUNDThis study sought to determine outcomes for patients with metastatic breast cancer (MBC) with no evidence of disease (NED) after treatment and to identify factors predictive of outcomes once the status of NED was attained.METHODSThis study reviewed 570 patients with MBC who were consecutively treated between January 2003 and December 2005. Ninety patients (16%) attained NED, which was defined as a complete metabolic response on positron emission tomography or sclerotic healing of bone metastases on computed tomography or magnetic resonance imaging. The median follow‐up for patients attaining NED was 100 months (range, 14‐134 months).RESULTSThe 3‐ and 5‐year overall survival (OS) rates were 44% and 24%, respectively, for the entire group and 96% and 78%, respectively, for those attaining NED. According to a landmark analysis, NED status was significantly associated with survival at 2 (P < .001; hazard ratio [HR], 0.23; 95% confidence interval [CI], 0.16‐0.34) and 3 years (P < .001; HR, 0.20; 95% CI, 0.14‐0.30). From the time of NED, the median survival was 102 months (range, 14‐134 months) with 5‐year OS and progression‐free survival (PFS) rates of 77% and 40%, respectively. According to a multivariate analysis, human epidermal growth factor receptor 2 positivity was significantly associated with OS in comparison with estrogen receptor positivity (P = .02; HR, 0.44; 95% CI, 0.21‐0.90), and trastuzumab use was significantly associated with PFS (P = .007; HR, 0.48; 95% CI, 0.28‐0.82). Thirty‐one patients (34%) with NED remained in remission at the last follow‐up.CONCLUSIONSMBC patients who attain the status of NED have significantly prolonged survival with a durable response to therapy. Ultimately, this study provides essential outcome data for clinicians and patients living with MBC. Cancer 2015;121:4324–32. © 2015 American Cancer Society.
Brush cytology for the detection of high‐risk HPV infection in oropharyngeal squamous cell carcinoma
Authors: Broglie Martina A. , Jochum Wolfram , Förbs Diana , Schönegg René , Stoeckli Sandro J. 
Published: September 2015

BACKGROUNDHigh‐risk human papillomavirus (HR‐HPV) infection is associated with improved prognosis and a better response to treatment in patients with oropharyngeal squamous cell carcinoma (OPSCC). Brush cytology is a noninvasive method with which to collect cells from the surface of mucosal lesions. The objective of the current study was to assess the performance of OPSCC brush cytology for the detection of HR‐HPV.METHODSLiquid‐based brush cytology specimens were prospectively collected during panendoscopy from 51 patients with OPSCC. Cell suspensions were analyzed with Papanicolaou staining, polymerase chain reaction‐based HPV DNA testing, and p16 immunostaining. HPV testing and p16 staining were also performed on paired OPSCC biopsy or surgical resection specimens. The detection of HR‐HPV DNA alone and the combined positivity for HR‐HPV DNA and p16 protein in dysplastic squamous cells were used to calculate accuracy, sensitivity, specificity, and positive and negative predictive values for HR‐HPV detection using brush cytology samples.RESULTSApproximately 96% of OPSCC brush cytology samples (49 of 51 samples) were classified as satisfactory for evaluation. Dysplastic squamous cells were found in 88% of samples (43 of 49 samples). HPV DNA testing was conclusive in 95% of samples (41 of 43 samples) and revealed HR‐HPV DNA in approximately 54% of patients (22 of 41 patients) (HPV type 16 in 19 patients and HPV type 33 in 3 patients). Approximately 49% of brush cytology samples (20 of 41 samples) were positive for HR‐HPV DNA and p16 expression. The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of brush cytology to identify HR‐HPV DNA‐positive and p16‐positive OPSCC samples were 88%, 83%, 94%, 95%, and 81%, respectively.CONCLUSIONSBrush cytology appears to be a valid approach with which to determine the HR‐HPV status of patients with OPSCC. Cancer (Cancer Cytopathol) 2015;123:732–738. © 2015 American Cancer Society.
Sensing Characteristics of a Graphene‐like Boron Carbide Monolayer towards Selected Toxic Gases
Authors: Mahabal Manasi S. , Deshpande Mrinalini D. , Hussain Tanveer , Ahuja Rajeev 
Published: September 2015

AbstractBy using first‐principles calculations based on density functional theory, we study the adsorption efficiency of a BC3 sheet for various gases, such as CO, CO2, NO, NO2, and NH3. The optimal adsorption position and orientation of these gas molecules on the BC3 surface is determined and the adsorption energies are calculated. Among the gas molecules, CO2 is predicted to be weakly adsorbed on the graphene‐like BC3 sheet, whereas the NH3 gas molecule shows a strong interaction with the BC3 sheet. The charge transfer between the molecules and the sheet is discussed in terms of Bader charge analysis and density of states. The calculated work function of BC3 in the presence of CO, CO2, and NO is greater than that of a bare BC3 sheet. The decrease in the work function of BC3 sheets in the presence of NO2 and NH3 further explains the affinity of the sheet towards the gas molecules. The energy gap of the BC3 sheets is sensitive to the adsorption of the gas molecules, which implies possible future applications in gas sensors.