bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMULIHAN PASCA BENCANA ERUPSI DI KAWASAN WISATA MERAPI DAERAH ISTIMEWA YOGYAKARTA DITINJAU DARI MODEL PENTA HELIX
Authors: Pratiwi Tiffany Setyo , Chotimah Hidayat Chusnul 
Published: July 2024

Letusan Gunung Merapi di tahun 2010 telah menewaskan ratusan jiwa. Bencana tersebut telah memberikan dampak buruk terhadap berbagai aspek, termasuk kawasan wisata Merapi. Padahal wisata Merapi adalah sumber penghasilan warga sekitar. Upaya pemulihan dilakukan oleh berbagai pihak dari pemerintah dan sektor swasta dengan revitalisasi langsung melalui berbagai program. Penelitian ini akan memfokuskan seperti apa peran Penta Helix dalam pemulihan pasca bencana erupsi di kawasan wisata Merapi tahun 2010 hingga 2014. Penta Helix terbagi atas lima aktor: pemerintah, pihak swasta, akademisi, komunitas, dan media. Data penelitian diperoleh dari wawancara dengan pemerintah yakni Badan Penanggulangan Bencana Daerah dan komunitas organisasi Tim Reaksi Cepat (TRC) di DIY dan salah satu korban erupsi. Penelitian ini juga di dukung dengan data-data sekunder seperti website pemerintah, berita di internet, dan jurnal. Hasil penelitian menunjukkan bahwa peran dari model Penta Helix dilakukan melalui beragam festival, donasi, dan promosi yang melibatkan: Badan Penanggulangan Bencana Daerah di DIY dan Sleman, Dinas Kebudayaan dan Pariwisata DIY and Sleman (pemerintah), Tim Reaksi Cepat dan Merapi Rescue Community (komunitas), Universitas Gadjah Mada (akademis), Kedaulatan Rakyat (media massa), juga Metro TV dan TV One (sektor privat) dan beberapa aktor lainnya. Sehingga upaya-upaya tersebut berkontribusi dalam peningkatan jumlah wisatawan yang membantu percepatan pemulihan wisata Merapi.
Kata kunci: Penta Helix, Pasca Bencana, dan Wisata Merapi
PENGAWASAN PELAKSANAAN PROTOKOL KESEHATAN OLEH SATUAN POLISI PAMONG PRAJA DI KABUPATEN JAYAPURA PROVINSI PAPUA
Authors: Salama Timoty Yusuf , Manuri Mercy Christa 
Published: July 2024

Penyebaran COVID-19 terjadi dengan cepat hampir ke seluruh pelosok dunia termasuk Indonesia Kasus Positif yang semakin meningkat membuat pemerintah mengeluarkan beberapa peraturan daerah mengenai disiplin Protokol Kesehatan sebagai upaya pencegahan dan pengendalian Covid- 19 dalam hal ini Satuan Polisi Pamong Praja memiliki tugas pengawasan protokol kesehatan. Masalah yang dihadapi dalam Penelitian ini meningkatnya kasus Covid- 19 pada Kabupaten jayapura dari yang Positif, dirawat sampai dengan meninggal dunia sehingga perlu adanya Penelitian ini dilakukan untuk mengetahui bagaimana pengawasan pelaksanaan Protokol Kesehatan yang dilakukan satuan polisi pamong praja Kabupaten Jayapura, faktor yang menghambat serta upaya dalam megatasinya. Penelitian ini menggunakan teori Pengawasan yang Robbin and Coulter dalam Satriadi (2016). Metode Penelitian dalam penelitian ini menggunakan metode deskriptif kualitatif dengan memberikan gambaran fakta serta data yang terjadi di lapangan melalui teknik pengumpulan data yaitu observasi, wawancara dan dokumentasi. Teknik pengumpulan data adalah wawancara, dokumentasi, observasi. Teknik analisis data yang digunakan adalah model interaktif dengan cara reduksi data, penyajian data, dan penarikan kesimpulan. Hasil dari Penelitian menunjukan bahwa Satuan Polisi Pamong Praja menjadi kunci penting pengawasan Protokol Kesehatan CovId-19 di Kabupaten Jayapura dan telah menjalankan tugasnya dengan baik dilihat dari menurunnya angka Covid-19 dikabupaten Jayapura. Adanya beberapa hambatan dalam pelaksanaan tugasnya baik dari faktor internal dan faktor eksternal. Adapun upaya yang dilakukan oleh Satuan Polisi Pamong Praja dalam pengawasan Pelaksanaan Protokol kesehatan Covid-19 di Kabupaten Jayapura adalah melakukan sosialisasi lanjutan serta meredam berita-berita hoax yang tersebar serta memberikan sanksi yang sesuai dengan Peraturan Bupati yang berlaku.
KINERJA SATUAN POLISI PAMONG PRAJA DALAM PENEGAKAN PERATURAN BUPATI NOMOR 32 TAHUN 2020 DI KABUPATEN SIDENRENG RAPPANG PROVINSI SULAWESI SELATAN
Authors: Madjid Udaya , Arijah Andi Wardina , Dewi Suci Prasita 
Published: July 2024

Masih banyaknya kasus pelanggar protokol kesehatan yang terjadi di masyarakat Kabupaten Sidenreng Rappang, hingga hanya dalam kurung waktu beberapa minggu saja sudah terkumpul sebanyak Rp 4.000.000 (empat juta rupiah) denda yang dikumpulkan serta ribuan kasus yang dikenakan denda administrasi hingga denda sosial, adapun kasus positif dilihat dari data yang disajikan terjadi kenaikan yang signifikan dari jumlah kasus positif COVID-19. Tujuan penelitian ini dilakukan untuk mengetahui kinerja Satuan Polisi Pamong Praja dalam penegakan Peraturan Bupati Nomor 32 Tahun 2020 di Kabupaten Sidenreng Rappang, mengetahui faktor penghambat serta upaya mengatasinya. Metode yang digunakan yaitu metode penelitian kualitatif dengan pendekatan Deskriptif induktif, Teknik pengumpulan data yang dilakukan penulis yaitu observasi, wawancara dan dokumentasi. Hasil penelitian menunjukkan kinerja SATPOL-PP dinilain belum optimal karena 3 dari 5 indikator kinerja belum berjalan dengan baik. Yaitu produktivitas, kualitas layanan dan responsivitas.kemudian melalui hasil kinerja Satuan Polisi Pamong Praja Kabupaten indenreng Rappang Provinsi Sulawesi Selatan terdapat upaya yang dilakukan untuk mengatasi berbagai permasalahan terkait penertiban hukum protokol kesehatan Covid-19 yakni mempertahankan sikap dan prinsip humanis dalam pelaksanaan penertiban hukum protokol kesehatan Covid-19 guna merangkul masyarakat agar tidak lagi melanggar Peraturan Daerah yang berlaku khususnya tentang Peraturan Bupati dalam penertiban hukum protokol kesehatan Covid-19. Selain itu, pengembangan inovasi-inovasi baru untuk menghadapi berbagai masalah terkait penertiban hukum protokol kesehatan Covid-19 di wilayah Kabupaten Sidenreng Rappang Provinsi Sulawesi Selatan.

Kata Kunci: Kinerja, Satuan Polisi Pamong Praja, Covid-19
Hubungan Kadar Trigliserida dengan Tekanan Sistolik dan Diastolik
Authors: Thoha Thoha , Kusniawati Kusniawati , Subiakto Toto , Akbar Roby Rahmadi 
Published: July 2024

Hipertensi merupakan kondisi saat tekanan di dalam pembuluh darah meningkat melebihi batas normal. Kadar trigliserida yang tinggi dapat berkaitan dengan peningkatan tekanan darah yang dapat menyebabkan gangguan kerja jantung. Tujuan penelitian ini untuk mengetahui adanya hubungan trigliserida dengan tekanan sistolik dan diastolik. Penelitian ini merupakan penelitian korelatif analitik dengan pendekatan cross-sectional. Sejumlah 38 responden yang merupakan individu dewasa usia 30-50 tahun dilibatkan dalam penelitian dengan teknik pengambilan sampel accidental sampling. Uji korelasi antar variabel menggunakan Spearman’s rank. Hasil penelitian menunjukkan rerata kadar trigliserida adalah 203,79 (SD=40,036), tekanan sistolik 149,05 (SD=24,052), dan tekanan diastolik 89,00 (SD=11,128). Hasil uji korelasi Spearman menunjukkan tidak ada korelasi yang signifikan antara kadar trigliserida dengan tekanan sistolik (p value=0.472) dan tekanan diastolik (p value=0,710). Kadar trigliserida pasien hipertensi dengan tekanan sistolik dan diastol yang meningkat melebihi tekanan normal sering ditemukan tinggi. Namun kondisi trigliserida yang tinggi belum tentu diikuti dengan peningkatan tekanan sistolik dan diastolik.
Efektivitas Sari Kurma terhadap Peningkatan Pertumbuhan Baduta Stunting
Authors: Apriyanti Ika , Lufar Nay , Rahma Nayya Aqnia 
Published: July 2024

Di tahun 2021, Kota Cilegon berada pada katagori zona stunting kuning dengan prevalensi 20,6%. Angka prevalensi stunting ini menunjukkan bahwa anak usia 6 bulan hingga 2 tahun tidak mendapatkan praktik pemberian makan yang memadai dan makanan pendamping yang sesuai. Salah satu cara untuk meningkatkan asupan gizi bayi di 1000 hari pertama kehidupan adalah dengan penggunaan bahan pangan fungsional, seperti kurma. Tujuan dari penelitian ini adalah untuk mengevaluasi sari kurma sebagai tambahan untuk koreksi pertumbuhan pada anak stunting di Kota Cilegon. Kelompok pemberian sari kurma merupakan kelompok yang digunakan dalam desain pre-experimental pre-test-post test. Analisis data yang digunakan adalah uji T dependen (paired t test). Sampel penelitian ini adalah 10 baduta (bayi bawah dua tahun) yang dinyatakan stunting yang dipilih dengan teknik total sampling. Hasil penelitian menunjukkan bahwa terdapat perbedaan penambahan panjang badan (p=0,001) dan kenaikan berat badan (p=0,000) setelah diberikan sari kurma. Hal ini menunjukkan sari kurma dapat mengoreksi pertumbuhan pada baduta stunting. Orang tua baduta perlu diinformasikan dan dididik tentang nilai gizi dan konsumsi sari kurma untuk meningkatkan status gizi anak.
Improving stereoselectivity of phosphotriesterase (PTE) for kinetic resolution of chiral phosphates
Authors: Jaito Nongluck , Phetlum Suthathip , Saeoung Titiporn , Tiyasakulchai Thanat , Srimongkolpithak Nitipol , Uengwetwanit Tanaporn 
Published: July 2024

Specific stereoisomer is paramount as it is vital for optimizing drug efficacy and safety. The quest for the isolation of desired stereoisomer of active pharmaceutical ingredients or key intermediates drives innovation in drug synthetic and biocatalytic methods. Chiral phosphoramidate is an important building block for the synthesis of antiviral drugs such as remdesivir and sofosbuvir. Given the clinical potency of the (Sp)-diastereomer of the drugs, an enzyme capable of completely hydrolyzing the (Rp)-diastereomer is needed to achieve the purified diastereomers via biocatalytic reaction. In this study, protein engineering of phosphotriesterase (PTE) was aimed to improve the specificity. Employing rational design and site-directed mutagenesis, we generated a small library comprising 24 variants for activity screening. Notably, W131M and I106A/W131M variants demonstrated successful preparation of pure (Sp)-diastereomer of remdesivir and sofosbuvir precursors within a remarkably short hydrolysis time (&lt;20 min). Our work unveils a promising methodology for producing pure stereoisomeric compounds, utilizing novel biocatalysts to enable the chemoenzymatic synthesis of phosphoramidate nucleoside prodrugs.
Recent advances in crack detection technologies for structures: a survey of 2022-2023 literature
Authors: Kaveh Hessam , Alhajj Reda 
Published: July 2024

IntroductionCracks, as structural defects or fractures in materials like concrete, asphalt, and metal, pose significant challenges to the stability and safety of various structures. Addressing crack detection is of paramount importance due to its implications for public safety, infrastructure integrity, maintenance costs, asset longevity, preventive maintenance, economic impact, and environmental considerations.MethodsIn this survey paper, we present a comprehensive analysis of recent advancements and developments in crack detection technologies for structures, with a specific focus on articles published between 2022 and 2023. Our methodology involves an exhaustive search of the Scopus database using keywords related to crack detection and machine learning techniques. Among the 129 papers reviewed, 85 were closely aligned with our research focus.ResultsWe explore datasets that underpin crack detection research, categorizing them as public datasets, papers with their own datasets, and those using a hybrid approach. The prevalence and usage patterns of public datasets are presented, highlighting datasets like Crack500, Crack Forest Dataset (CFD), and Deep Crack. Furthermore, papers employing proprietary datasets and those combining public and proprietary sources are examined. The survey comprehensively investigates the algorithms and methods utilized, encompassing CNN, YOLO, UNet, ResNet, and others, elucidating their contributions to crack detection. Evaluation metrics such as accuracy, precision, recall, F1-score, and IoU are discussed in the context of assessing model performance. The results of the 85 papers are summarized, demonstrating advancements in crack detection accuracy, efficiency, and applicability.DiscussionNotably, we observe a trend towards using modern and novel algorithms, such as Vision Transformers (ViT), and a shift away from traditional methods. The conclusion encapsulates the current state of crack detection research, highlighting the integration of multiple algorithms, expert models, and innovative data collection techniques. As a future direction, the adoption of emerging algorithms like ViT is suggested. This survey paper serves as a valuable resource for researchers, practitioners, and engineers working in the field of crack detection, offering insights into the latest trends, methodologies, and challenges.
Coupling of the best-estimate system code and containment analysis code and its application to TMLB’ accident
Authors: Wu Xiaoli , Zheng Zhifeng , Deng Jian , Liu Yu , Lu Qi , Xiang Qingan , Chen Chong , Sun Hongping , Lu Yazhe , Shen Danhong , Li Wei 
Published: July 2024

With the development of advanced pressurized water reactor technology, the thermal-hydraulic coupling effect between the containment and the primary system becomes increasingly tight. In order to meet the demand for integrated safety analysis between the containment and the primary system, this paper investigates a direct coupling method between the best-estimate system code Advanced Reactor Safety Analysis Code and the containment analysis program ATHROC (Analysis of Thermal Hydraulic Response Of Containment). The feasibility of this direct coupling method and the applicability of the coupled program for overall safety analysis are demonstrated using Marviken two-phase flow release experiments. The ATHROC/ARSAC coupled program is employed to analyze the impact of the pressure relief function of the CPR1000 nuclear power plant pressurizer on the behavior of the primary system and containment during the TMLB’ accident. The calculation results indicate that these measures can reduce the pressure of the primary system to the level acceptable by the low-pressure injection system, but at the same time, they cause the pressure in the containment to rise to nearly 0.4 MPa. Therefore, to ensure the structural integrity of the containment, it is necessary for the non-passive hydrogen recombiner to effectively reduce the hydrogen concentration, thereby avoiding additional pressure increase in the containment due to hydrogen deflagration, which could lead to overpressure failure. The findings of this study are of significant reference value for improving the safety performance of thermal-hydraulic systems in operational Gen-II and advanced Gen-III pressurized water reactor nuclear power plants.
Validation of a methane oxidation biosystem design methodology using numerical modeling
Authors: Dulac Yohan , Nelson Brienne R. , Zytner Richard G. , Cabral Alexandre R. 
Published: July 2024

Introduction: Methane oxidation biosystems (MOBs) are cost effective engineered systems capable of catalyzing the transformation of CH4 into CO2 biotically, thereby mitigating emissions from landfills.Method: In this study we validate how accurately one can predict the hydraulic behaviour of a MOB using numerical modeling. More precisely how one can identify the length of unrestricted gas migration (LUGM), a critical design criterion for effective methane abatement biosystems. Laboratory experiments were conducted to obtain the material properties for a compost mixed with plastic pellets, and sand. With the water retention curve and air permeability function, we predicted the hydraulic performance of a MOB using Hydrus-2D. We then designed and constructed a MOB and monitored several key parameters for 12 months. The validation of the design methodology was conducted using field measurements, while actual climatic data was used as input in numerical modeling.Results: The air permeability function was an appropriate activation function for determining LUGM. Accordingly, the predicted hydraulic behaviour matched the measured hydraulic behaviour reasonably well, validating the proposed procedure.
Dermoscopy of skin metastases in advanced cancer—systemic (visceral, hematologic) and cutaneous
Authors: Simionescu Olga , Petrică Marian , Avram Alina Mariana , Costache Mariana , Scurtu Lucian G. , Tudorache Sorin Ioan , Iorga Polixenia Georgeta , Grigore Mariana 
Published: July 2024

IntroductionSkin metastases arise in 10% of cancer patients, but standardized dermoscopy diagnostic criteria for skin metastases remain poor. This study's objective was to analyze the dermoscopy features of skin metastases from advanced systemic and cutaneous cancers.MethodsA retrospective study on 715 dermoscopy images of skin metastases from 33 patients with various primary cancers (breast, ovary, melanoma, non-melanoma skin cancer, and chronic leukemia) attending two academic centers between 2013 and 2023 was performed. Four independent observers blindly analyzed patterns, colors, vessels, and elementary lesions for each metastasis (30 parameters in total).ResultsThe structureless white pattern was the most prominent indicator of cutaneous metastasis (81.26%, p &lt; 0.001). Regardless of the primary tumor, colors pink, red, white, and tan were identified. Elementary lesions were infrequent, except for melanoma metastases that displayed dots (13.23%) and globules (11.11%). Breast cancer metastases presented: blue (41.48%) and red (34.32%) colors, irregular vessels (13.58%), and a blue-naevus pattern (22.22%). Melanoma metastases displayed: a blue-naevus pattern (61.38%), a blue color (85.71%), and a structureless-blue combination pattern (79.37%). Non-melanoma skin cancer metastases were characterized by vascular (42.11%) and angioma-like (31.58%) patterns, pink (57.89%) and red (57.89%) colors, irregular (57.89%), thin hairpin (47.37%), comma (47, 37%), and thick hairpin (26, 32%) vessels and a red, white and irregular vessels combination pattern (52, 63%). A pink structureless combination pattern was frequent (61.05%) in chronic leukemia metastases. Ovarian cancer metastases displayed a white and tan structureless combination pattern (100%) and frequently had dotted vessels (42.85%).ConclusionPapules and nodules with a white structureless pattern suggest skin metastases, regardless of the primary tumor. A blue structureless lesion is indicative of melanoma metastasis and a vascular pattern with irregular vessels indicates a non-melanoma skin cancer metastasis. Dermoscopy stands as a reliable non-invasive diagnostic method for suspected cutaneous metastases in patients with a known cancer history.
Circulating adipose-tissue miRNAs in gastrointestinal cancer patients and their association with the level and type of adiposity at body composition analysis
Authors: Tambaro Federica , Imbimbo Giovanni , Pace Valentina , Amabile Maria Ida , Rizzo Veronica , Orlando Simona , Lauteri Giulia , Ramaccini Cesarina , Catalano Carlo , Nigri Giuseppe , Muscaritoli Maurizio , Molfino Alessio 
Published: July 2024

BackgroundAdipose tissue (AT) wasting in cancer is an early catabolic event with negative impact on outcomes. Circulating miRNAs may promote body weight loss and cachexia. We measured circulating miRNAs linked to AT alterations and compared their levels between i) gastrointestinal (GI) cancer patients and controls, ii) cachectic and non-cachectic cancer patients, and iii) according to adiposity level and its distribution.MethodsPatients with GI cancer and subjects with benign diseases as controls were considered. Cachexia was assessed and adiposity evaluated by CT-scan for subcutaneous AT area (SAT), visceral AT area and the total AT area (TAT). MiRNAs involved were measured in plasma by RT-qPCR.Results37 naïve GI cancer patients and 14 controls were enrolled. Patients with cachexia presented with lower SAT compared to non-cachectic (p &lt; 0.05). In cancer patients, we found higher levels of miR-26a, miR-128, miR-155 and miR-181a vs. controls (p &lt; 0.05). Cancer patients with BMI < 25 kg/m2 showed higher levels of miR-26a vs. those with BMI ≥ 25 (p = 0.035). MiR-26a and miR-181a were higher in cachectic and non-cachectic vs. controls (p &lt; 0.05). Differences between cachectic and controls were confirmed for miR-155 (p &lt; 0.001) but not between non-cachectic vs. control (p = 0.072). MiR-155 was higher in cachectic patients with low TAT vs. those without cachexia and high TAT (p = 0.036).ConclusionOur data confirm a modulation of specific and different miRNAs involved in AT metabolism in cancer and cachexia. MiR-155 levels were higher in patients presenting with cachexia and low adiposity with implications in the pathogenic mechanisms and clinical consequences of GI cancer patients.
Diagnostic accuracy of a machine learning-based radiomics approach of MR in predicting IDH mutations in glioma patients: a systematic review and meta-analysis
Authors: Chen Xiaoli , Lei Junqiang , Wang Shuaiwen , Zhang Jing , Gou Lubin 
Published: July 2024

ObjectivesTo assess the diagnostic accuracy of machine learning (ML)-based radiomics for predicting isocitrate dehydrogenase (IDH) mutations in patients with glioma.MethodsA systematic search of PubMed, Web of Science, Embase, and the Cochrane Library from inception to 1 September 2023, was conducted to collect all articles investigating the diagnostic performance of ML for the prediction of IDH mutations in gliomas. Two reviewers independently screened all papers for eligibility. Methodological quality and risk of bias were assessed using the METhodological RadiomICs Score and Quality Assessment of Diagnostic Accuracy Studies-2, respectively. The pooled sensitivity, specificity, and 95% confidence intervals were calculated, and the area under the receiver operating characteristic curve (AUC) was obtained.ResultsIn total, 14 original articles assessing 1740 patients with gliomas were included. The AUC of ML for predicting IDH mutation was 0.90 (0.87–0.92). The pooled sensitivity, specificity, and diagnostic odds ratio were 0.83 (0.71–0.90), 0.84 (0.74–0.90), and 25 (12,50) respectively. In subgroup analyses, modeling methods, glioma grade, and the combination of magnetic resonance imaging and clinical features affected the diagnostic performance in predicting IDH mutations in gliomas.ConclusionML-based radiomics demonstrated excellent diagnostic performance in predicting IDH mutations in gliomas. Factors influencing the diagnosis included the modeling methods employed, glioma grade, and whether the model incorporated clinical features.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/#myprospero, PROSPERO registry (CRD 42023395444).