bluuebunny/crossref_metadata_2025_split huggingface dataset:
Idiopathic hypokalemic periodic paralysis: A series of cases clustered in a part of Eastern India
Authors: Mukherjee Joydeep , Chakraborty Durga Prasad , Sinharoy Uma , Saha Shankar Prasad 
Published: June 2015

Background: Most of the studies on hypokalemic periodic paralysis (HOPP) in India and abroad had described secondary causes as the origin of the disease. We had observed a series of HOPP cases clustered within 40 kilometers around Bankura, a district town of West Bengal, Eastern India. The aim of our study was to probe into the clinical, biochemical and electrophysiological details of the cases, which were found to be idiopathic. Material and Methods: 32 idiopathic HOPP cases, attending the neurology OPD or admitted in Bankura Sammilani Medical College & Hospital (BSMCH), were selected from October 2006 to May 2008. All the secondary causes of HOPP were excluded. The patients were evaluated and the data was analyzed. Results: Cases were clustered within a 40-kilometer radius from Bankura town, location of BSMCH. Male: female = 4.3:1. Median age of onset was 23.5 years (4-50 years). Median number of attacks was 2.5, (1 to 70); duration 3 hours - 6 days, median 3 days. Strenous physical activity was most common precipitating factor. 25% had bulbar symptoms, 9.4% had bladder dysfunction and 46.9% had diminished to absent deep tendon reflexes. Mean serum potassium = 2.45 mEq/L (1.4 – 3.1 mEq/L). Conclusion: We had observed a group of idiopathic HOPP cases within a relatively small area in a short span of time in contrast to most other Indian studies, where the share of idiopathic aetiology is comparatively smaller. This underscores the importance of a larger study with genetic analysis on the aetiology of the idiopathic HOPP in this area.DOI: http://dx.doi.org/10.3126/ajms.v6i6.12482 Asian Journal of Medical Sciences Vol.6(6) 2015 83-87
Enhanced Plasma H2S Levels Associated With Fasting Blood Glucose In Type-2 Diabetes Mellitus
Authors: Saha Pinaki , Banerjee Piyasa , Pal Prasenjit , Auddya Lakshmisona , Sen Santanu , Sau Tanmay Jyoti , Kumar Arun , Biswas Utpal Kumar 
Published: June 2015

Introduction: A number of recent literatures suggest a potential role of H2S and H2S modifying agents in the etiology and management of type-2 diabetes mellitus. Objective: The current study was aimed to evaluate the plasma levels of H2S in the patients with type 2 Diabetes mellitus and to find out if there is any relationship of H2S concentrations with the fasting blood glucose levels. Methods: Plasma H2S levels were measured in sixty two recently diagnosed type 2 diabetic patients and compared with similar number of healthy volunteers as controls. Results: The plasma H2S level in the patients ( 81.17 ± 16.40 micromol/l ) is significantly higher (P< 0.001) than the healthy controls (50.69 ± 8.69 micromol/l) and the H2S levels in plasma have significant positive correlation (r= 0.359, P=0.004) with fasting blood glucose levels. Conclusion: The present study has elucidated that the patients with type-2 diabetes mellitus are associated with elevated plasma H2S levels which are well correlated with glucose levels. This reveals a potential the role of H2S modulators towards the management of this non-communicable epidemic disorder. DOI: http://dx.doi.org/10.3126/ajms.v6i6.12532Asian Journal of Medical Sciences Vol.6(6) 2015 11-15
An inflammatory myofibroblastic tumor of the urinary bladder in a young girl presenting as acute kidney injury due to obstructive uropathy
Authors: Umesh L , Shivaprasad SM , Niranjan MR , Sathish Kumar MM , Leelavathi V , Sridhara CG 
Published: June 2015

Inflammatory myofibroblastic tumor (IMT) of the bladder is an uncommon benign tumor of the urinary bladder, which is of unknown neoplastic potential, characterized by spindle cell proliferation with characteristic fibro inflammatory and pseudosarcomatous appearance of mesenchymal origin. Myofibroblastic tumor, is also known as inflammatory pseudotumor or pseudosarcoma. Bladder location is very uncommon. We report a case of a young girl who presented with acute kidney injury due to obstructive uropathy. On evaluation found to have Inflammatory myofibroblastic tumor at the base of the urinary bladder, which gradually improved with hemodialysis and successive urological interventions. DOI: http://dx.doi.org/10.3126/ajms.v6i6.12535 Asian Journal of Medical Sciences Vol.6(6) 2015 80-82
Expressions of HPV 16-E6 in esophageal carcinoma and it's clinical significance
Authors: Zhao Xing , Sahi Rajina , Zhao Yu-Yang , Wang Jun , Li Chun- Hui 
Published: June 2015

Aim: To explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.Materials and Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.Results: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had correlation with invasive depth (P<0.05), but not with patient age, lymph node metastasis, tumor size (P>0.05).Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma. DOI: http://dx.doi.org/10.3126/ajms.v6i6.12537 Asian Journal of Medical Sciences Vol.6(6) 2015 39-42
Expression of P53, PTEN and S100A4 in invasive ductal breast cancer and the clinical significance
Authors: Gang Zhang , Zhong Li , Xiao-meng Lin , Jun-hua Zhang , Yong Cui , Xing Zhao 
Published: June 2015

Objective: To investigate the expression level of P53, PTEN and S100A4 in invasive ductal breast cancer and the clinical significance. Methods: SP immunohistochemical and Western blot analysis were used to detect the expression of P53, PTEN and S100A4 protein in invasive ductal breast cancer, adjacent tissues and benign breast lesions. The results were aimed to explore the correlation of p53, PTEN, S100A4 and analyze the relationship between indicators and clinical pathology. Results: Immunohistochemical results showed that the positive rates of p53 and S100A4 in invasive ductal breast cancer were 47.69% and 56.92%, which were significantly higher than that in benign breast lesions (16.00%, 22.00%) (p<0.05); The positive rates of PTEN in invasive ductal breast cancer was 24.62%, which were significantly lower than that in benign breast lesions (52.00%) (p<0.05); The expression of p53 was negatively correlated with PTEN in invasive ductal breast cancer (p<0.05). Western blot results revealed that the relative expression levels of p53, PTEN and S100A4 protein in invasive ductal breast cancer were 0.967±0.066, 0.785±0.044, 1.065±0.073, which were significant difference with that in benign breast lesions (0.549±0.032, 1.245±0.059, 0.370±0.065) (p<0.05); The expression of p53 has correlation with histological differentiating degree and lymph node metastasis (p<0.05), but it was irrelevant to the age, tumor size and clinical grade (p>0.05). The expression of S100A4 has correlation with clinical grade and lymph node metastasis (p<0.05), but no association with the age, tumor size and histological differentiating degree was observed in this study (p>0.05). The expressions of PTEN has correlation with lymph node metastasis p<0.05, but no association with the age, tumor size, clinical grade and histological differentiating degree was noted in our study (p>0.05). Conclusion: Expression of P53, PTEN and S100A4 can be expected to be taken as to the prognosis biomarkers of breast cancer and potential targets for new and effective treatment strategies for breast cancer.DOI: http://dx.doi.org/10.3126/ajms.v6i6.12599 Asian Journal of Medical Sciences Vol.6(6) 2015 43-47
Effect of step up exercise on cognitive attention with stroop test in Bengali male college students
Authors: Debray Parthasarathi , Biswas Susanta , Biswas Prasanta , Saha Tapasi , Pal Madhu Sudan 
Published: June 2015

Introduction: A beneficial influence of exercise on cognitive and brain functions has been established. Exercise is drawing increasing research attention for improving neurocognitive functions.Aims: The aim of the present study is to examine the effect of step up exercise on mental attention with strop test in Bengali male college students.Methodology: Twenty eight (28) apparently healthy male sedentary college students from the same socio-economic background, having mean age of 22.4 ± 1.02 years, body height of 165.3 ± 6.34 cm and body weight of 55.5 ± 9.01 kg were recruited for the present study on the basis of random sampling from the undergraduate students of the NS Mahavidyalaya of Tripura. A computer based modified ‘Stroop color word’ test based on the original Stroop test (Stroop, 1935) to identify cognitive performance. After completion of stroop test in resting sitting condition participants were asked to complete Queen College Step Test to measure VO2 max. After completion of 3 mins step up exercise a recovery time of 5-15 seconds were taken for VO2 measurement and immediately after taking recovery pulse participants were asked to perform stroop III subtask to see the effect of exercise on the cognitive performance of the college students of Tripura.Results: The mean VO2 max to be found 49.1 ± 6.25 ml.kg-1.min-1. The mean time to complete Stroop sub task Tasks III was found 194.3 (±46.34) sec. After 3 minutes step-up exercise it has been shown that the mean stroop III score was improved from 194.3 (±46.34) to 160.4 (± 31.42) sec. Conclusion: It is observed in the present study that the speed of performance (i.e., stoop tasks) is improved after short term moderate exercise. DOI: http://dx.doi.org/10.3126/ajms.v6i6.12602 Asian Journal of Medical Sciences Vol.6(6) 2015 66-69
Prevalence of thyroid dysfunction in patients with Type 2 diabetes mellitus and its correlation with insulin resistance and serum markers for autoimmune thyroiditis
Authors: Sahu Sulagna , Dutta Soumya Kanti , Kuiri Shib Shankar , Nandi Mintu Mohan , Kabiraj Pranay , De Utpal 
Published: June 2015

Background: The term “THYROID DIABETES” was coined in early literature to depict the influence of thyroid hormone excess in deterioration of glucose control. Although autoimmune thyroid disease is more prevalent in Type1 Diabetes mellitus as a result of their common origin, the prevalence of hypothyroidism and hyperthyroidism is supposed to be similar to that of general population in patient with type2 DM. The purpose of the study was to evaluate the prevalence of thyroid dysfunction in patients with type2 diabetes mellitus and to correlate thyroid abnormalities with insulin resistance and serum markers for autoimmune thyroiditis. Methods: 120 cases of type2 diabetes mellitus patients satisfying WHO criteria without pre-existing thyroid disease were included in the study. Thyroid function test, fasting serum insulin was done.HOMA-IR & HOMA-B (HOMA-Homeostatic model assessment) was calculated. Serum antithyroid peroxidase anibody (anti-TPO) and antithyroglobulin antibodies (anti-TG) and ANA were done. Results: Prevalence of thyroid dysfunction in type2 diabetes mellitus was 28.33% according to our study, which included overt hypothyroidism (15%), subclinical hypothyroidism (8.33%), secondary hypothyroidism (0.83%), overt hyperthyroidism (1.67%) and subclinical hyperthyroidism (2.5%). Anti TPO and anti TG antibodies were elevated in 62.07% cases of hypothyroidism, 40% cases of hyperthyroidism and 6.9% euthyroid cases of type2 DM. Anti TPO and antiTG antibodies were significantly raised in type2DM patient with hypothroidism than that of euthyroid (p value<0.0001). Compared to euthyroid diabetics, hypothyroid cases had lower values of insulin resistance markers like fasting insulin, HOMA-IR and HOMA-B. Hyperthyoid cases had higher values. Conclusion: Hyperthyroid diabetics have higher insulin resistance as fasting insulin, HOMA-IR, HOMA-B showed negative correlation with TSH. (p value<0.05).DOI: http://dx.doi.org/10.3126/ajms.v6i6.12603 Asian Journal of Medical Sciences Vol.6(6) 2015 33-38
Serum levels of tumor necrosis factor -alpha and hsCRP in patients with breast cancer and correlation with histological parameters
Authors: Sharma Anisha , Goswami Binita , Gupta Nikhil , Chakraborty Baidarbhi 
Published: June 2015

Background: Breast cancer is now the second most commonly cancer diagnosed in women after cervical cancer in India. Presentation at late stage further aggravates the problem. The outcome of breast cancer is usually determined by multiple factors.Aims and Objectives:This study was designed with the aim to investigate any correlation between serum tumor necrosis factor alpha and hsCRP in breast cancer with histological parameters of tumor behavior. Materials and Methods: A total of 30 histological confirmed cases of locally advanced breast cancer were enrolled for study. Total duration of study was two years. HsCRP was determined by solid phase direct sandwich ELISA method (Diaclone, France).Similarly TNF-α was also determined by Enzyme-linked immunosorbent method. Three-dimensional tumor size was determined radiologically through mammography. CT scan and MRI scan were taken at the time of diagnosis to detect metastasis. The data on tumor size, estrogen receptors status, lymph node status and TNM staging were reviewed and recorded. Results: Levels of TNF-α and hsCRP in patients with more advanced TNM staging, more advanced lymph node status and high histological grade were significantly raised. Similarly, their levels were significantly raised with increasing grade of adipose tissue invasion. Levels of TNF-α and hs CRP were also significantly raised in patients with estrogen receptor status positive whereas increase in levels of these markers was not significant in progesterone receptor status positive. Conclusion: Preoperative evaluation of tumor necrosis factor alpha and high sensitivity C-reactive protein may be valuable parameters for reflecting the severity of invasive breast cancer.DOI: http://dx.doi.org/10.3126/ajms.v6i6.12714 Asian Journal of Medical Sciences Vol.6(6) 2015 6-10
Hybrid 18F-labeled Fluoride Positron Emission Tomography/Magnetic Resonance (MR) Imaging of the Sacroiliac Joints and the Spine in Patients with Axial Spondyloarthritis: A Pilot Study Exploring the Link of MR Bone Pathologies and Increased Osteoblastic Activity
Authors: Buchbender Christian , Ostendorf Benedikt , Ruhlmann Verena , Heusch Philipp , Miese Falk , Beiderwellen Karsten , Schneider Matthias , Braun Juergen , Antoch Gerald , Baraliakos Xenofon 
Published: July 2015

Objective.The biologically active molecule used in positron emission tomography (PET) for depiction of osteoblastic activity is 18F-labeled fluoride (18F-F). We examined whether inflammatory or chronic changes on magnetic resonance imaging (MRI) in the sacroiliac joints (SIJ) and the spines of patients with active ankylosing spondylitis (AS) are linked to osteoblastic activity, assessed by PET/MRI.Methods.Thirteen patients with AS (mean age 37.8 ± 11.4 yrs, Bath AS Disease Activity Index > 4, no anti-TNF treatment) underwent 3-Tesla whole-spine and SIJ PET/MRI. Two independent readers recorded pathologic changes related to vertebral (VQ) or SIJ quadrants (SQ). Final scores were based on reader agreement.Results.A total of 104 SQ and 1196 VQ were examined. In SIJ, bone marrow edema (BME) was seen in 44.2%, fat deposition (FD) in 42.3%, and 18F-F in 46.2% SQ. BME alone was associated with 18F-F in 78.6% and FD alone in only 7.7% SQ, while the combination BME/FD was associated with 18F-F in 72.2% SQ. Erosions, sclerosis, and ankylosis alone were rarely associated with 18F-F. In the spine, BME alone was seen in 9.9%, FD in 18.2%, and 18F-F in 5.4% VQ. BME alone was associated with 18F-F in 14.3% and FD alone in 8.7% VQ, while the combination BME/FD was associated with 18F-F in 40.6% VQ.Conclusion.In this study of hybrid 18F-F PET/MRI of patients with active AS, we show that BME rather than chronic changes is associated with osteoblastic activity, while the combination of BME and FD showed the highest 18F-F uptake. The use of PET/MRI in prediction of future syndesmophyte formation in AS needs further exploration in prospective studies.
Efficacy of Triamcinolone Hexacetonide versus Methylprednisolone Acetate Intraarticular Injections in Knee Osteoarthritis: A Randomized, Double-blinded, 24-week Study
Authors: Lomonte Andrea Barranjard Vannucci , de Morais Marina Gonçalves Veras , de Carvalho Lina Oliveira , Zerbini Cristiano Augusto de Freitas 
Published: July 2015

Objective.Intraarticular (IA) corticosteroid injections are broadly used in knee osteoarthritis (OA); however, the best corticosteroid agent is not well defined. The aim of the present study was to compare the efficacy of triamcinolone hexacetonide (TH) and methylprednisolone acetate (MA) injections in knee OA.Methods.Patients with symptomatic knee OA and Kellgren-Lawrence grade II or III were randomized to receive 40 mg of IA TH or MA. Evaluations were performed at 4, 12, and 24 weeks. The primary outcome was a change in the patient’s assessment of pain by visual analog scale from baseline to Week 4. Secondary outcomes included a global assessment of the disease by patients and physicians, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lequesne index (LI), and Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) criteria of response. Generalized estimating equations were used in statistical analysis.Results.The intention-to-treat population included 100 patients; 50 in each study arm. A significant improvement in pain was observed at Week 4 for both groups (p < 0.0001), with no difference between them (p = 0.352). This improvement was sustained up to Week 24. A significant improvement from the baseline was observed for both the patient’s and the physician’s global assessments, WOMAC questionnaire, and LI, with no differences between the groups. Improvements in the secondary outcomes were sustained during the study. The OMERACT-OARSI criteria of response was achieved by 74% and 72% of patients in the TH and the MA groups, respectively.Conclusion.Both IA therapies are equally effective, and improvement in pain and function can be sustained for up to 24 weeks.Controlled-trials.comidentifier:ISRCTN15077843.
Influence of Institutional Guidelines on Oral Hygiene Practices in Intensive Care Units
Authors: Kiyoshi-Teo Hiroko , Blegen Mary 
Published: July 2015

BackgroundMaintaining oral hygiene is a key component of preventing ventilator-associated pneumonia; however, practices are inconsistent.ObjectivesTo explore how characteristics of institutional guidelines for oral hygiene influence nurses’ oral hygiene practices and perceptions of that practice.MethodsOral hygiene section of a larger survey study on prevention of ventilator-associated pneumonia. Critical care nurses at 8 hospitals in Northern California that had more than 1000 ventilator days in 2009 were recruited to participate in the survey. Twenty-one questions addressed oral hygiene practices and practice perceptions. Descriptive statistics, analysis of variance, and Spearman correlations were used for analyses.ResultsA total of 576 critical care nurses (45% response rate) responded to the survey. Three types of institutional oral hygiene guidelines existed: nursing policy, order set, and information bulletin. Nursing policy provided the most detail about the oral hygiene care; however, adherence, awareness, and priority level were higher with order sets (P &lt; .05). The content and method of disseminating these guidelines varied, and nursing practices were affected by these differences. Nurses assessed the oral cavity and used oral swabs more often when those practices were included in institutional guidelines.ConclusionsThe content and dissemination method of institutional guidelines on oral hygiene do influence the oral hygiene practices of critical care nurses. Future studies examining how institutional guidelines could best be incorporated into routine workflow are needed.
Study of the concept of dvandva in the Pātañjala Yogasūtra from a philosophical and psycho-physiological perspective
Authors: Yadav Seema Rani 
Published: July 2015

Background:
In order to have a clearer understanding of yogic concepts as described in the Pātañjala Yogasūtra (PYS), the seminal, most authentic and authoritative, but extremely compact ancient text of yoga, there is a need for their critical study with reference to relevant commentaries and secondary sources of the PYS.

Aim:
The current study focused on the word dvandva (general meaning - pair, conflict) as used in the PYS, as well as various relevant commentaries on the PYS, in an attempt to explain the end effect of yogic āsana in relation to dvandva.

Methods:
A thorough review of the PYS and 22 commentaries on it that pertained to the concept of dvandva was conducted. The commentaries referred to were of two types: (a) Direct commentaries on the PYS and (b) indirect commentaries, i.e., commentaries on bhāṣya (commentary) of Vyāsa on the PYS. After this review, descriptive and analytical methods were used to correlate the philosophical understanding of dvandva, found in the PYS and its 22 relevant commentaries, with the psycho-physiological understanding of the concept.

Results:
There are mainly five pairs of words regarding dvandva pertaining to āsana in PYS and the 22 commentaries referred to. They are śïta-uṣna, sukha-duḥkha, māna-avamāna, kāma-krodha, and kṣut-trṣnā/pipāsā. These five pairs of words are either opposites or compound words, and all of them seem to represent disturbing elements of a conflict. The psycho-physiological mechanisms, by which these five pairs of disturbing elements related to dvandva become ineffective as a result of perfection in āsana, can be hypothesized.

Conclusion:
The current study has attempted to critically analyze one of the important yogic concepts, dvandva. An effort has also been made to understand the mechanisms of transcending dvandva as a result of perfection in āsana, which the extremely compact PYS or its direct and indirect commentary seems to fall short of elucidating. Thus, the present study has thrown light on the need for fundamental studies of important terms or concepts mentioned in the PYS to understand their deeper meanings and probable mechanisms of action.