bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recombinant human erythropoietin alters gene expression and stimulates proliferation of MCF-7 breast cancer cells
Authors: Trost Nina , Stepisnik Tina , Berne Sabina , Pucer Anja , Petan Toni , Komel Radovan , Debeljak Natasa 
Published: October 2013

AbstractBackground. Functional erythropoietin (EPO) signaling is not specific only to erythroid lineages and has been confirmed in several solid tumors, including breast. Three different isoforms of erythropoietin receptor (EPOR) have been reported, the soluble (EPOR-S) and truncated (EPOR-T) forms acting antagonistically to the functional EPOR. In this study, we investigated the effect of human recombinant erythropoietin (rHuEPO) on cell proliferation, early gene response and the expression of EPOR isoforms in the MCF-7 breast cancer cell line.Materials and methods. The MCF-7 cells were cultured with or without rHuEPO for 72 h or 10 weeks and assessed for their growth characteristics, expression of early response genes and different EPOR isoforms. The expression profile of EPOR and EPOR-T was determined in a range of breast cancer cell lines and compared with their invasive properties.Results. MCF-7 cell proliferation after rHuEPO treatment was dependent on the time of treatment and the concentration used. High rHuEPO concentrations (40 U/ml) stimulated cell proliferation independently of a preceding long-term exposure of MCF-7 cells to rHuEPO, while lower concentrations increased MCF-7 proliferation only after 10 weeks of treatment. Gene expression analysis showed activation of EGR1 and FOS, confirming the functionality of EPOR. rHuEPO treatment also slightly increased the expression of the functional EPOR isoform, which, however, persisted throughout the 10 weeks of treatment. The expression levels of EPOR-T were not influenced. There were no correlations between EPOR expression and the invasiveness of MCF-7, MDA-MB-231, Hs578T, Hs578Bst, SKBR3, T-47D and MCF-10A cell lines.Conclusions. rHuEPO modulates MCF-7 cell proliferation in time- and concentration-dependent manner. We confirmed EGR1, FOS and EPOR as transcription targets of the EPO-EPOR signaling loop, but could not correlate the expression of different EPOR isoforms with the invasiveness of breast cancer cell lines.
Bernstein type operators having 1 and x j as fixed points
Authors: Finta Zoltán 
Published: October 2013

AbstractFor certain generalized Bernstein operators {L n} we show that there exist no i, j ∈ {1, 2, 3,…}, i < j, such that the functions e i(x) = x i and e j (x) = x j are preserved by L n for each n = 1, 2,… But there exist infinitely many e i such that e 0(x) = 1 and e j (x) = x j are its fixed points.
An inverse problem for Sturm-Liouville operators on the half-line having Bessel-type singularity in an interior point
Authors: Fedoseev Alexey 
Published: October 2013

AbstractWe study the inverse problem of recovering Sturm-Liouville operators on the half-line with a Bessel-type singularity inside the interval from the given Weyl function. The corresponding uniqueness theorem is proved, a constructive procedure for the solution of the inverse problem is provided, also necessary and sufficient conditions for the solvability of the inverse problem are obtained.
Application of high intensity THz pulses for gas high harmonic generation
Authors: Balogh Emeric , Fülöp József , Hebling János , Dombi Péter , Farkas Győző , Varjú Katalin 
Published: October 2013

AbstractThe main effects of an intense THz pulse on gas high harmonic generation are studied via trajectory analysis on the single atom level. Spectral and temporal modifications to the generated radiation are highlighted.
The Impact of Financial Openness on the Size of Utility-enhancing Government
Authors: Erauskin Iñaki 
Published: October 2013

Abstract
In this paper, we employ a portfolio approach based on a two-country world to study the impact of financial openness on the size of government and on other key economic variables, including the consumption-wealth ratio, the growth rate of wealth, and welfare (assuming that public spending is utility enhancing). The model suggests that the size of government, the consumption-wealth ratio, and welfare should be greater in an open economy because of higher productivity and/or less volatility because of risk sharing. The theoretical results for the growth rate depend on differences in productivity and in consumption-wealth ratios. The empirical evidence — based on a sample of 49 countries from 1970 to 2009—broadly supports the main theoretical results of the model.
« Je serai trappeur, mineur… »
Authors: Rialland Ivanne 
Published: October 2013

Perçus à l’époque comme typiques du « nouveau mal du siècle », tel que le nomme en 1924 Arland dans La Nouvelle revue française, les romans de Soupault mettent en leur coeur l’aventure pour montrer l’impossible adhésion au monde de l’homme occidental moderne : l’homme blanc n’y trouve qu’ennui tandis que l’écriture romanesque empêche tout départ véritable en perpétuant la chaîne des souvenirs. Il ne reste au romancier qu’à se faire le témoin émerveillé de l’énergie de l’homme noir. Celui-ci introduit non seulement dans la prose narrative un autre rapport au monde et au temps, mais ce faisant bouleverse l’écriture en la fragmentant : au lieu de dissoudre le réel dans le souvenir et l’ennui, la prose parvient alors à lui rendre son opacité signifiante.
Vies parallèles des hommes insignifiants, par Marcel Aymé
Authors: Jiménez Pedro Pardo 
Published: October 2013

Dans l’oeuvre romanesque de Marcel Aymé, l’aventure fonctionne comme le mécanisme qui permet à l’auteur de confronter la vie quotidienne de ses personnages avec une autre vie possible, une vie nouvelle tantôt recherchée — en vain —comme un moyen d’échapper à la médiocrité de l’existence, tantôt survenue, au contraire, comme une encombrante expérience d’ordre surnaturel. La philosophie qui se dégage de cette confrontation de vies parallèles tient en même temps de la résignation et du scepticisme : l’homme ne peut ou, respectivement, ne veut se soustraire à sa condition. La vie quotidienne constitue un acquis trop précieux pour le compromettre dans des projets évanescents, susceptibles d’élargir la casuistique déjà instable de l’imprévu. Ainsi, le plus sage est de ne pas désirer ce qu’on n’est pas ou ce qu’on n’est plus, de s’accommoder de son destin, car en fin de compte, on n’y peut rien changer. Une telle attitude est propre à Marcel Aymé, mais peut-être aussi au moment historique où il écrit, un temps où l’on aspire non pas à vivre d’heureuses aventures, mais à vivre tout court.
L’aventure vécue comme possibilité
Authors: Bélisle Mathieu 
Published: October 2013

Si au tournant du XXe siècle la découverte de l’ordre des possibles semble ouvrir pour la pensée et l’imagination un espace infini, et par là même enivrant, les romans de Raymond Queneau, qui paraissent dans le second tiers du siècle, expriment un point de vue plus dubitatif. C’est que contrairement par exemple au personnage proustien qui peut contempler les vies possibles sans jamais se confondre avec elles, c’est-à-dire sans jamais que le je se perde dans les méandres de la virtualité, les personnages de Queneau vivent une situation plus précaire : ils ne jouissent pas d’une vie intérieure telle qu’elle leur assurerait, à tous les moments de leur parcours, la solidité du lien de soi à soi au fondement du principe d’authenticité : pour aussi belle et séduisante que la possibilité lui apparaisse, quelque chose comme une conscience inaliénable de soi le retient de s’y abandonner complètement et partant, de se perdre dans le dédale de ses fantasmes. Ainsi, tandis que le moi proustien se présente comme un astre qui attire dans son orbite tous les possibles « satellisés », c’est-à-dire des possibles qui viennent enrichir le moi et en confirmer aussi bien le pouvoir attractif que la réalité effective, le moi quenien cède successivement à l’attraction des divers possibles qu’il rencontre.
Dans Loin de Rueil (1944), roman auquel la présente étude est consacrée, la possibilité devient plus forte que la réalité ; plutôt que de la compléter, elle l’écarte ou la supplante avec pour résultat que son héros, Jacques L’Aumône, ne jouit pas d’un enrichissement qui viendrait de l’addition des possibles. Le personnage « abdique » plutôt à chaque occasion une identité pour une autre, jusqu’à se perdre lui-même ou, du moins, jusqu’à ce qu’il ne soit plus rien d’autre qu’une image, dès lors moins un personnage qu’un dispositif. Le roman de Queneau est ainsi l’occasion d’exploiter le potentiel d’un roman et d’un personnage en mettant en évidence le fourmillement des possibles et de s’interroger sur leur nature et leur valeur. Que faire de toutes les existences « irréalisées », de tous les fantômes de ces vies possibles qui nous accompagnent et ne cessent de rappeler à quel point notre vie, notre seule vie, se campe à l’intérieur de bornes étroites ? La vie que nous menons, avec son histoire, ses exigences, sa trajectoire et sa fin possible, est-elle la seule qu’il nous soit donné de mener ?
Bacterial colonization and extinction on marine aggregates: stochastic model of species presence and abundance
Authors: Kramer Andrew M. , Lyons M. Maille , Dobbs Fred C. , Drake John M. 
Published: October 2013

AbstractOrganic aggregates provide a favorable habitat for aquatic microbes, are efficiently filtered by shellfish, and may play a major role in the dynamics of aquatic pathogens. Quantifying this role requires understanding how pathogen abundance in the water and aggregate size interact to determine the presence and abundance of pathogen cells on individual aggregates. We build upon current understanding of the dynamics of bacteria and bacterial grazers on aggregates to develop a model for the dynamics of a bacterial pathogen species. The model accounts for the importance of stochasticity and the balance between colonization and extinction. Simulation results suggest that while colonization increases linearly with background density and aggregate size, extinction rates are expected to be nonlinear on small aggregates in a low background density of the pathogen. Under these conditions, we predict lower probabilities of pathogen presence and reduced abundance on aggregates compared with predictions based solely on colonization. These results suggest that the importance of aggregates to the dynamics of aquatic bacterial pathogens may be dependent on the interaction between aggregate size and background pathogen density, and that these interactions are strongly influenced by ecological interactions and pathogen traits. The model provides testable predictions and can be a useful tool for exploring how species‐specific differences in pathogen traits may alter the effect of aggregates on disease transmission.
Management of Early‐stage Esophageal Neoplasia (MESEN) Consensus
Authors: Nieponice Alejandro , Badaloni Adolfo E. , Jobe Blair A. , Hoppo Toshitaka , Pellegrini Carlos , Velanovich Vic , Falk Gary W. , Reavis Kevin , Swanstrom Lee , Sharma Virender K. , Nachman Fabio , Ciotola Franco F. , Caro Luis E. , Cerisoli Cecilio , Cavadas Demetrio , Figueroa Luis Durand , Pirchi Daniel , Gibson Michael , Elizalde Santiago , Cohen Henry 
Published: October 2013

AbstractBackgroundTreatment of esophageal adenocarcinoma often involves surgical resection. Newer technologies in interventional endoscopy have led to a substantial paradigm shift in the management of early‐stage neoplasia in Barrett’s esophagus comprising high‐grade dysplasia (HGD), intramucosal carcinoma, and, in some cases, submucosal carcinoma. However, there has been no consensus regarding the indications for esophageal preservation in these cases. In this work, consensus guidelines were established for the management of early‐stage esophageal neoplasia considering clinically relevant aspects (age, comorbidities, and social environment) in each scenario.MethodsSeventeen experts were invited to participate based on their background and clinical expertise at high‐volume centers. A questionnaire was created that included four clinical scenarios covering a wide range of situations within HGD and/or early esophageal neoplasia, particularly where controversies are likely to exist. Each of the clinical scenarios was open to discussion subdivided by patient age (20, 50, and 80 s). For each clinical scenario an expert was chosen to defend that position. Each defense triggered a subsequent discussion during a consensus meeting. Conclusions of that discussion together with an accompanying literature analysis allowed experts to confirm or change their original choices and served as the basis for the recommendations stated in this article.ResultsThere was 100 % consensus supporting esophageal preservation in patients with HGD, independent of patient age or Barrett’s length. In patients with T1a adenocarcinoma, consensus for preservation was not reached (65 %) for young and middle‐aged individuals but was supported for elderly patients (100 %). For T1b adenocarcinoma, consensus was reached for surgical resection (90 %), leaving organ preservation for patients with very low risk of nodal invasion or poor surgical candidates.ConclusionAdvances in endoscopic imaging and therapy allow for organ preservation in most settings of early‐stage neoplasia of the esophagus, provided that the patient understands the implications of this decision.
Clinical Utility of a Novel Hybrid Position Combining the Left Lateral Decubitus and Prone Positions During Thoracoscopic Esophagectomy
Authors: Kaburagi Takuji , Takeuchi Hiroya , Kawakubo Hirofumi , Omori Tai , Ozawa Soji , Kitagawa Yuko 
Published: October 2013

AbstractBackgroundWe developed a hybrid of the prone and left lateral decubitus positions for thoracoscopic esophagectomy (TE) in 2009. This study aimed to evaluate the feasibility of applying this novel TE position.MethodsWe retrospectively analyzed 78 patients who underwent TE at our institution between 2005 and 2010. Altogether, 33 patients underwent TE in the left lateral decubitus position (LD‐TE) from 2005 to 2008, and 45 underwent TE in the hybrid position (hybrid‐TE) from 2009 to 2010. Radical lymphadenectomy along the bilateral recurrent laryngeal nerves was performed in both groups. The thoracic duct was preserved in the LD‐TE group and resected in the hybrid‐TE group. In the LD‐TE group, all thoracic procedures were performed with the patient in the left lateral decubitus position. In the hybrid‐TE group, the upper mediastinal procedure was performed with the patient in the left lateral decubitus position, and procedures at the middle and lower mediastinum were performed with the patient in the prone position under CO2 pneumothorax.ResultsHybrid‐TE was associated with increased operating time. The number of harvested mediastinal nodes and the PaO2/FiO2 ratio on postoperative day 1 were both greater in this position. Although vocal cord palsy was observed more frequently in the hybrid‐TE group, there was no significant difference in the rate of other complications or in‐hospital mortality between the two groups.ConclusionsThe novel hybrid position is believed feasible for use during TE. We believe that this position facilitates a more radical mediastinal lymphadenectomy with minimal intraoperative pulmonary damage.
MRI Detection of Forearm Soft Tissue Injuries with Radial Head Fractures
Authors: McGinley Joseph C. , Gold Garry , Cheung Emilie , Yao Jeffrey 
Published: October 2013

Background This study aims to evaluate the incidence of forearm soft tissue abnormalities associated with radial head fracture severity based on the Mason classification system. Methods Eighteen patients (age 18–45 years) were prospectively evaluated with elbow radiographs and magnetic resonance imaging (MRI) following longitudinal forearm trauma. MRI was performed within 10 days of the initial injury. Radiographs and MR images were evaluated in a blinded fashion by two musculoskeletal radiologists. Results Thirteen of 18 patients presented with Mason type I radial head fractures. In all patients with Mason type I fractures, the interosseous membrane (IOM) was intact. Two patients had Mason type II fractures with associated partial and compete tearing of the IOM and three patients had Mason type III fractures with complete tearing of the IOM. Edema was noted in the pronator quadratus in six of 13 type I injuries and seen in all type II and III injuries. No structural forearm soft tissue abnormalities were present in patients with Mason type I injuries. The presence of edema within the pronator quadratus correlated with distal forearm pain. Conclusions The severity of radial head fracture correlates with longitudinal forearm injury evidenced by the presence of IOM tearing. The findings suggest patients with Mason type II or III fractures of the radial head should undergo further evaluation of the forearm for associated soft tissue injuries. Edema within the pronator quadratus was present following forearm trauma regardless of the severity of fracture and was related to symptomatic forearm pain.
Synthesis of Carbonated Cotton Seed Oil and Its Application as Lubricating Base Oil
Authors: Zhang Letao , Luo Yanping , Hou Zhenshan , He Zhenhong , Eli Wumanjiang 
Published: October 2013

AbstractEpoxidized cotton seed oil (ECSO) was conveniently synthesized from cotton seed oil (CSO) in the presence of hydrogen peroxide, formic acid, and phosphoric acid. Then the ECSO was converted into carbonated cotton seed oil (CCSO) by reacting with CO2 using tetrabutylammonium bromide as a catalyst. The reaction conditions including reaction temperature, pressure, reaction time and the amount of catalyst were examined. In addition, the final product (CCSO) from cyclic addition reaction was characterized by FT‐IR, 1H NMR and TGA. Compared with CSO and ECSO, CCSO showed excellent thermal and oxidation stability. Additionally, the CCSO's properties of extreme pressure, anti‐wear and friction reduction were tested and analyzed. The results indicated that it could be used as potential lubricating base oil.
Learning curve analysis of the first 100 robotic‐assisted laparoscopic hysterectomies performed by a single surgeon
Authors: Lin Jeff F. , Frey Melissa , Huang Jian Qun 
Published: October 2013

AbstractObjectiveTo review the first 100 cases of robotic‐assisted hysterectomy performed by an individual surgeon.MethodsA retrospective cohort study of the first 100 consecutive patients who underwent robotic‐assisted hysterectomy by a newly trained minimally invasive gynecologic surgeon was conducted. Demographic factors and short‐term surgical outcome variables were abstracted from medical records. We examined univariate associations and performed multivariable modeling with linear regression, and modeled the learning curve for total operative time using power‐law function.ResultsMean age was 46 years; mean body mass index was 27.8 kg/m2. Median operative time was 120 minutes; median estimated blood loss was 100 mL. On multivariable analysis, case number (β –0.296; P < 0.005) and uterine weight (β 0.330; P < 0.005) independently predicted operative time, while uterine weight (β 0.387; P < 0.005) independently predicted estimated blood loss. The point at which the slope of the case number–operative time curve crosses –1.0 is at case 28 when uncontrolled and at case 24 when controlled for other factors.ConclusionThere was a significantly decreased operative time for robotic‐assisted hysterectomies performed later in the surgeon's learning curve. Surgical proficiency, as measured by operative time, seemed to be attained after 20–30 cases.
Free Speech, Hate Speech, and the Problem of (Manufactured) Authority
Authors: Sorial Dr. Sarah 
Published: October 2013

Abstract
In this paper, I suggest that the concept of incitement as a way of identifying hate speech sometimes locates the harm caused by speech in the wrong sorts of places. Hate speech expressed in the form of “reasoned argument” or academic debate by persons with the relevant authority or expertise potentially causes more harm, though perhaps in less obvious ways. Literature on the concept of authority has demonstrated the way authoritative speakers or speakers with perceived expertise are able to secure uptake for their views. In this paper, I demonstrate how authority and expertise can also be manufactured, enabling speakers to secure uptake in the same sorts of ways as legitimately authoritative or expert speakers. While I am not suggesting legal penalties for speakers who manufacture authority in these ways, I am arguing that we should nevertheless be sensitive to the ways in which this can occur, how it might cause various kinds of harm, and how these harms might be mitigated.
Associations of serum insulin-like growth factor-I and insulin-like growth factor-binding protein 3 levels with biomarker-calibrated protein, dairy product and milk intake in the Women's Health Initiative
Authors: Beasley Jeannette M. , Gunter Marc J. , LaCroix Andrea Z. , Prentice Ross L. , Neuhouser Marian L. , Tinker Lesley F. , Vitolins Mara Z. , Strickler Howard D. 
Published: October 2013

It is well established that protein–energy malnutrition decreases serum insulin-like growth factor (IGF)-I levels, and supplementation of 30 g of whey protein daily has been shown to increase serum IGF-I levels by 8 % after 2 years in a clinical trial. Cohort studies provide the opportunity to assess associations between dietary protein intake and IGF axis protein levels under more typical eating conditions. In the present study, we assessed the associations of circulating IGF axis protein levels (ELISA, Diagnostic Systems Laboratories) with total biomarker-calibrated protein intake, as well as with dairy product and milk intake, among postmenopausal women enrolled in the Women's Health Initiative (n 747). Analyses were carried out using multivariate linear regression models that adjusted for age, BMI, race/ethnicity, education, biomarker-calibrated energy intake, alcohol intake, smoking, physical activity and hormone therapy use. There was a positive association between milk intake and free IGF-I levels. A three-serving increase in milk intake per d (approximately 30 g of protein) was associated with an estimated average 18·6 % higher increase in free IGF-I levels (95 % CI 0·9, 39·3 %). However, total IGF-I and insulin-like growth factor-binding protein 3 (IGFBP-3) levels were not associated with milk consumption and nor were there associations between biomarker-calibrated protein intake, biomarker-calibrated energy intake, and free IGF-I, total IGF-I or IGFBP-3 levels. The findings of the present study carried out in postmenopausal women are consistent with clinical trial data suggesting a specific relationship between milk consumption and serum IGF-I levels, although in the present study this association was only statistically significant for free, but not total, IGF-I or IGFBP-3 levels.
KRULL DIMENSION OF AFFINOID ENVELOPING ALGEBRAS OF SEMISIMPLE LIE ALGEBRAS
Authors: ARDAKOV KONSTANTIN , GROJNOWSKI IAN 
Published: October 2013

AbstractUsing Beilinson–Bernstein localisation, we give another proof of Levasseur's theorem on the Krull dimension of the enveloping algebra of a complex semisimple Lie algebra. The proof also extends to the case of affinoid enveloping algebras.
Taxation, Dividends, and Share Repurchases: Taking Evidence Global
Authors: Jacob Marcus , Jacob Martin 
Published: October 2013

AbstractWe compile a comprehensive international dividend and capital gains tax data set to study tax-based explanations of corporate payout for a panel of 6,035 firms from 25 countries for the period 1990–2008. We find robust evidence that the tax penalty on dividends versus capital gains corresponds closely with firms’ propensity to pay dividends and repurchase shares, and with the amount of dividends and shares repurchased. Our coefficient estimates suggest a smaller tax effect than reported in recent single-country, single-event studies. Instead, our results correspond more closely with historic long-term estimates of the elasticity of dividends.