bluuebunny/crossref_metadata_2025_split huggingface dataset:
COASTing Through Bedside Report
Authors: Webster Kristi , Hlebichuk Jeanne , Jensen Lillian , Zastrow Rachel 
Published: August 2024

Background:
Bedside shift report improves patient satisfaction, peer accountability, communication, and decreases safety events.

Local Problem:
Clinical practice of bedside report varied prior to the pandemic. Due to limited personal protective equipment and exposure risk, bedside report was halted during the pandemic.

Approach:
The Iowa Model of Evidence-Based Practice was used to guide this project. To standardize communication during bedside report, safety data and literature were reviewed and grouped by themes. The acronym COAST was developed, consisting of code status, oxygen, access, safety, and tubes/drains. These elements were to be discussed at the bedside during handoff.

Results:
Compliance with completing elements of COAST increased during the pilot, 9- and 12-month sustainment periods. Additional safety-related outcomes of cardiopulmonary resuscitation wristband application, falls, and good catches improved. Notably, overtime declined.

Conclusions:
A bedside report with standardized communication focusing on safety elements can improve compliance with adoption and patient safety outcomes.
Change in Brow Position After Upper Blepharoplasty With or Without Internal Browpexy
Authors: Menderes Adnan , Çağlı Hasan Basri 
Published: August 2024

Background
Only upper blepharoplasty can cause a change in the eyebrow position, so browpexy can be combined with blepharoplasty in selected patients. There are many brow lifting techniques, both surgical and nonsurgical, and internal browpexy is one of the most widely used surgical brow lifting techniques. The purpose of this study was to evaluate the change in brow position after upper blepharoplasty with or without internal browpexy using preoperative and postoperative photographs.

Methods
Patients who underwent upper blepharoplasty by a single surgeon at Dokuz Eylul University Hospital between 2018 and 2022 were retrospectively evaluated. A total of 48 patients, 30 of whom underwent upper blepharoplasty only and 18 of whom underwent upper blepharoplasty combined with internal browpexy, were examined to present the change in brow position postoperatively. Preoperative and postoperative photographs were analyzed using the ImageJ program and the proportional changes in brow height were shown.

Results
The first group, which only underwent upper blepharoplasty only, consisted of 30 patients (62.5%), all female; the second group, which underwent upper blepharoplasty and internal browpexy, consisted of 18 patients (37.5%), all female. The change at the midpupil level was determined as a 6.13% decrease in the first group and a 2.99% increase in the second group; at the brow peak level, this change was a 6.2% decrease in the 1st group and a 4.38% increase in the 2nd group.

Conclusions
In cases of dermatochalasis, blepharoplasty alone can cause a shortening of the distance between the eyebrow and the upper eyelid groove and an unaesthetic appearance. Internal browpexy is an easy-to-apply technique that allows stabilization of the eyebrow after skin excision and a small amount of elevation.
Drug-Induced Intracranial Hypertension: The Adverse Effects of Acne Medications and Topical Retinoids
Authors: Shaia Jacqueline K. , Rock Jenna R. , Singh Rishi P. , Talcott Katherine E. , Cohen Devon A. 
Published: August 2024

Background:
Tetracyclines and vitamin A derivatives, major components in acne care and antiaging products, have been associated with the development of drug-induced intracranial hypertension (DIIH). Treatment practices and longitudinal visual outcomes have been highly understudied in DIIH. The purpose of this study was to provide management guidelines for DIIH and report visual outcomes of patients with DIIH.

Methods:
This was a single institute ophthalmology center case–control study where patients were seen between June 1, 2012, and September 1, 2023, in the United States. Patients with an International Classification of Disease (ICD) code for IIH and meeting the IIH diagnostic criteria who were taking a tetracycline or a vitamin A derivative during their diagnosis were included in this study. Patients were stratified into the following 3 categories: tetracyclines only, vitamin A derivatives only, or both, and compared with Kruskal–Wallis rank-sum tests. Poor visual outcomes were evaluated for and defined as a visual field mean deviation (peripheral visual measure) of −7 dB or greater. Individuals were followed for up to 1.5 years after diagnosis.

Results:
Among patients with IIH (n = 839), DIIH occurred in 8.10% of them (n = 68) with 83% taking the medication for acne. 88% of cases were female, and patients had a mean age of 24.96 years. DIIH medications were taken for an average length of 25.79 weeks before diagnosis of IIH. 20.5% of patients with DIIH were not treated with any IIH medication and were discontinued from the inducing drug. 3 patients had a poor visual outcome on follow-up with all of them taking a vitamin A derivative (P < 0.05). Patients identified as having a poor visual outcome did not report discontinuing the DIIH drug (P < 0.05).

Conclusions:
We propose treatment guidelines highlighting that patients taking a DIIH medication who develop headaches or visual changes should be immediately referred to ophthalmology, removal of the offending agent, and close monitoring by ophthalmology for vision loss. Importantly, vitamin A DIIH may have more severe visual outcomes, but further research is needed to corroborate this finding.
Knowledge mapping of barriers and strategies for clinical practice guideline implementation: a bibliometric analysis
Authors: Tian Chen , Liu Yajie , Hou Liangying , Jiang Jingwen , Li Ying , Liu Jianing , Ye Ziying , Cheng Qianji , Ma Yan , Ning Jinling , Huang Jiajie , Wang Yong , Wang Yiyun , Tong Bo , Lu JiaLe , Ge Long 
Published: August 2024

ABSTRACT

Objective:
This study provides a comprehensive overview of the knowledge structure and research hotspots regarding barriers and strategies for the implementation of clinical practice guidelines.

Methods:
Publications on barriers and strategies for guideline implementation were searched for on Web of Science Core Collection from database inception to October 24, 2022. R package bibliometrix, VOSviewer, and CiteSpace were used to conduct the analysis.

Results:
The search yielded 21,768 records from 3,975 journals by 99,998 authors from 3,964 institutions in 186 countries between 1983 and 2022. The number of published papers had a roughly increasing trend annually. The United States, the United Kingdom, and Canada contributed the majority of records. The University of Toronto, the University of Washington, and the University of Sydney were the biggest node in their cluster on the collaboration network map. The three journals that published the greatest number of relevant studies were Implementation Science, BMJ Open, and BMC Health Services Research. Grimshaw JM was the author with the most published articles, and was the second most co-cited author. Research hotspots in this field focused on public health and education, evidence-based medicine and quality promotion, diagnosis and treatment, and knowledge translation and barriers. Challenges and barriers, as well as societal impacts and inequalities, are likely to be key directions for future research.

Conclusions:
This is the first bibliometric study to comprehensively summarize the research trends of research on barriers and strategies for clinical practice guideline implementation. A better understanding of collaboration patterns and research hotspots may be useful for researchers.

Spanish abstract:

http://links.lww.com/IJEBH/A247
Revealing the Auxetic Behavior of Biomimetic Multi-material and Region-specific Nanofibrous Scaffolds via Synchrotron Multiscale Digital Volume Correlation: Innovative Building Blocks for the Enthesis Regeneration
Authors: Sensini Alberto , Giacomini Francesca , Stamati Olga , Lukic Bratislav , Villanova Julie , Proudhon Henry , Gille Maryse , Birgani Zeinab Tahmasebi , Truckenmüller Roman , Tozzi Gianluca , van Griensven Martijn , Moroni Lorenzo 
Published: August 2024

AbstractEnthesis lesions are one of the prevalent causes of injuries in the tendon tissue. The gradient of mineralization, extracellular matrix organization and auxetic mechanical properties, make enthesis regeneration challenging. Innovative electrospun fascicle-inspired nanofibrous poly(L-lactic)acid/collagen type I blend scaffolds were developed. Specifically, a mineralized fibrocartilage-inspired region (with/without nano-mineralization with hydroxyapatite), where random and aligned nanofibers coexist, is connected to a tendon-like region made of aligned nanofibers, through a conical non-mineralized fibrocartilage-inspired junction. Scanning electron microscopy and synchrotron nano-tomography show the morphological biomimicry of scaffolds with the natural tendon fascicles. Human mesenchymal stromal cells spheroids cultures confirm a balanced expression of both tendon, cartilage and bone markers on the non-mineralized scaffolds compared with the mineralized ones. Mechanical tests, at different physiological strain-rates, reveal a biomimetic mechanical behavior of scaffolds and the ability of junctions to tune the mechanics of their surrounding sites. Multiscale synchrotronin situtensile tests, coupled with Digital Volume Correlation, elucidate the full-field strain distribution of scaffolds from the structural down to the nanofiber level, highlighting the auxetic mechanical behavior of junctions typical of the natural enthesis. The findings and cutting-edge investigations of our study suggest the suitability of these enthesis-inspired fascicles as innovative scaffolds for enhanced enthesis regeneration.
Applying a Random Forest Approach in Predicting Health Status in Patients with Carotid Artery Stenosis 30 Days Post-Stenting
Authors: Qureshi Omar , Mena-Hurtado Carlos , Romain Gaëlle , Cleman Jacob , Callegari Santiago , Smolderen Kim G. 
Published: August 2024

ABSTRACTBackgroundApproximately 20% of ischemic strokes in the U.S. result from carotid artery stenosis. Carotid artery stenting (CAS) can reduce stroke risk, but variability in post-stenting health outcomes and their predictors are poorly understood. We examined 30-day post-CAS health status and derived its most important clinical predictors.MethodsThe SAPPHIRE Worldwide Registry measured pre-procedural and 30-day health status for carotid artery stenosis patients undergoing transfemoral-CAS using the SF-36 or EQ-5D between 2010-2014. Four health status scores were calculated: SF-36 Mental Component Summary (MCS) and Physical Component Summary (PCS), EQ-5D Index Value and Visual Analogue Scale (VAS). Random Forest models ranked 66 pre-procedural candidate variables by relative importance in predicting 30-day post-CAS health status, stratified by symptomatic status. Variables with highest importance were used to develop predictive multivariable linear regression models. Model accuracy was assessed via Out of Bag accuracy and R-square, respectively.ResultsHealth status was assessed using the SF-36 in 3,017 patients and EQ-5D in 3,390 patients. Random Forest models demonstrated high accuracy (86.7% - 95.2%) and identified nine key predictors of post-stenting health status: pre-procedural health status (RI 100%), Modified Rankin Scale (RI 26.2-76.5%), NIH Stroke Scale (RI 12.1-28.0%), history of stroke (RI 9.2- 19.8%), congestive heart failure (RI 12.3-19.7%), spinal immobility (RI 6.7-31.0%), diabetes mellitus (RI 8.1-32.9%), severe pulmonary disease/COPD (RI 13.8-45.6%), and non-Hispanic/Latino ethnicity (RI 8.4-32.4%). Multivariable linear regression models explained ∼36- 61% of health status variance, with the asymptomatic SF-36 PCS model explaining 61%. SF-36 PCS and MCS models outperformed EQ-5D Index Value and VAS models regarding R-square and visual fit of observed vs. predicted values.ConclusionsWe successfully derived prediction models for patient-centered outcomes following CAS which partially explained 30-day post-CAS health status outcomes. Pre-procedural health status, stroke scale scores, and medical comorbidities should be considered when discussing health status benefits in pre-CAS treatment decision discussions.
scatterbar: an R package for visualizing proportional data across spatially resolved coordinates
Authors: Velazquez Dee , Fan Jean 
Published: August 2024

AbstractSummaryDisplaying proportional data across many spatially resolved coordinates is a challenging but important data visualization task, particularly for spatially resolved transcriptomics data. Scatter pie plots are one type of commonly used data visualization for such data but present perceptual challenges that may lead to difficulties in interpretation. Increasing the visual saliency of such data visualizations can help viewers more accurately identify proportional trends and compare proportional differences across spatial locations. We developed scatterbar, an open-source R package that extends ggplot2, to visualize proportional data across many spatially resolved coordinates using scatter stacked bar plots. We apply scatterbar to visualize deconvolved cell-type proportions from a spatial transcriptomics dataset of the adult mouse brain to demonstrate how scatter stacked bar plots can enhance the distinguishability of proportional distributions compared to scatter pie plots.Availability and implementationScatterbar is available athttps://github.com/JEFworks-Lab/scatterbarwith additional documentation and tutorials athttps://jef.works/scatterbar/.
TissuePlot: A Multi-Scale Interactive Visualization Tool for Spatial Data
Authors: Khawatmi Muhammed , Sailem Heba 
Published: August 2024

AbstractVisualization of spatial datasets is essential for understanding biological systems that are composed of several interacting cell types. For example, gene expression data at the molecular level needs to be interpreted based on cell type, spatial context, tissue type, and interactions with the surrounding environment. Recent advances in spatial profiling technologies allow measurements of the level of thousands of proteins or genes at different spatial locations along with corresponding cellular composition. Representing such high dimensional data effectively to facilitate data interpretation is a major challenge. Existing methods such as spatially plotted pie charts obscure underlying tissue regions and necessitate switching between different views for comprehensive interpretations. Here, we present TissuePlot, a novel method for visualizing spatial data. TissuePlot tackles the key challenge of visualizing multi-scale phenotypic data at molecular, cellular and tissue level in the context of their spatial locations. To this end, TissuePlot employs a transparent hexagon tesselation approach that utilizes object borders to represent cell composition or gene-level data without obscuring the underlying cell image. Moreover, we implement a multi-view interactive approach, to allow interrogating spatial tissue data at multiple scales linking molecular information to tissue anatomy and motifs. We demonstrate TissuePlot utility using mouse brain data from the Bio+MedVis Redesign Challenge 2024. Our tool is accessible athttps://sailem-group.github.io/TissuePlot/.
Membrane fusion-based drug delivery liposomes transiently modify the material properties of synthetic and biological membranes
Authors: Hammond Jayna , Richards Ceri J. , Ko YouBeen , Jonker Thijs , Åberg Christoffer , Roos Wouter H. , Lira Rafael B. 
Published: August 2024

AbstractMany drug targets are located in intracellular compartments of cells but they often remain inaccessible to standard imaging and therapeutic agents. To aid intracellular delivery, drug carrier nanoparticles have been used to overcome the barrier imposed by the plasma membrane. The carrier must entrap large amounts of cargo, efficiently and quickly deliver the cargo in the cytosol or other intracellular compartments, and must be as inert as possible. In other words, they should not induce cellular responses or alter the cell state in the course of delivery. Here, we show that cationic liposomes with high charge density efficiently fuse with synthetic membranes and the plasma membrane of living cells. Direct fusion efficiently delivers large amounts of cargo to cells and cell-like vesicles within seconds, bypassing slow and often inefficient internalization-based pathways. These effects depend on liposome charge density and, to some extent, liposome concentration and the helper lipid. However, fusion-mediated cargo delivery results in the incorporation of large amounts of foreign lipids that leads to changes in the material properties of these membranes, namely modifications in membrane packing and fluidity, induction of membrane curvature, decrease in surface tension and the formation of (short-lived) pores. Importantly, these effects are transient and liposome removal allows cells to recover their state prior to liposome interaction.
Exposures and conditions prior to age 16 are associated with dementia status among adults in the United States Health and Retirement Study
Authors: Cockell Scarlet , Wang Herong , Benke Kelly S. , Ware Erin B. , Bakulski Kelly M. 
Published: August 2024

AbstractBackgroundDementia susceptibility likely begins years before symptoms. Early life has not been comprehensively tested for dementia associations.MethodIn the US Health and Retirement Study (normal baseline cognition; n=16,509; 2008-2018 waves), 31 exposures before age 16 were retrospectively assessed with ten-year incident cognitive status (dementia, impaired, normal). Using parallel logistic models, each exposure was tested with incident cognition, adjusting for sex, baseline age, follow-up, race/ethnicity, personal/parental education.Result14.5% had incident impairment and 5.3% had dementia. Depression was associated with 1.71 (95%CI:1.28,2.26) times higher odds of incident impairment, relative to normal cognition. Headaches/migraines were associated with 1.63 (95%CI:1.18,2.22) times higher odds of incident impairment. Learning problems were associated with 1.75 (95%CI:1.05,2.79) times higher odds of incident impairment. Childhood self-rated health of fair (1.86, 95%CI:1.27,2.64) and poor (3.39, 95%CI:1.91,5.82) were associated with higher incident dementia odds, relative to excellent.ConclusionEarly life factors may be important for impairment or dementia, extending the relevant risk window.
Content quality versus sharing practices on social media: A cross-sectional analysis of nutrition information on Twitter
Authors: Ellis Cassandra H. , Ho Peter , Moore J Bernadette , Evans Charlotte E.L. 
Published: August 2024

AbstractObjectiveTo use the validated Online Quality Assessment Tool (OQAT) to assess; the quality of online nutrition information, the difference between re-tweeted articles, and the impact of original information source.SettingTwitter (X) as little known about the quality of nutrition information shared on the platform.DesignTweet Archiver collected tweets including the word ‘nutrition’ on seven randomly selected days in 2021. Tweets were screened for URL inclusion and grouped based on retweet status. URLs were assessed using the OQAT. Rasch measures defined quality levels (low, satisfactory, and high-quality), while mean differences of retweeted and non-retweeted data were assessed by the Mann-Whitney U test. The Cochran-Mantel-Haenszel test was used to compare information quality by source.ResultsIn total, 10,573 URLs were collected from 18,230 tweets. After screening for relevance, 1,005 articles were assessed (9,568 were out of scope) sourced from: professional-blogs (n=354), news-outlets (n=213), companies (n=166), personal-blogs (n=120), NGOs (n=60), magazines (n=55), universities (n=19), government (n=18). Rasch measures indicated the quality levels; 0-3.48, poor, 3.49-6.3, satisfactory and, 6.4-10, high quality. Personal and company-authored blogs were more likely to rank as poor quality. There was a significant difference in quality of retweeted (n=267, sum of rank, 461.6) and non-retweeted articles (n=738, sum of rank, 518.0), U = 87475, p=0.006, but no significant effect of information source on quality.ConclusionsLower-quality nutrition articles were more likely to be retweeted. Caution is required when using or sharing articles, particularly from companies and personal blogs, which tended to be lower-quality sources of nutritional information.
A Large Harmonized Upper and Lower Limb Accelerometry Dataset: A Resource for Rehabilitation Scientists
Authors: Miller Allison E. , Lohse Keith R. , Bland Marghuretta D. , Konrad Jeffrey D. , Hoyt Catherine R. , Lenze Eric J. , Lang Catherine E. 
Published: August 2024

AbstractWearable sensors can measure movement in daily life, an outcome that is salient to patients, and have been critical to accelerating progress in rehabilitation research and practice. However, collecting and processing sensor data is burdensome, leaving many scientists with limited access to such data. To address these challenges, we present a harmonized, wearable sensor dataset that combines 2,885 recording days of sensor data from the upper and lower limbs from eight studies. The dataset includes 790 individuals ages 0 – 90, nearly equal sex proportions (53% male, 47% female), and representation from a range of demographic backgrounds (69.4% White, 24.9% Black, 1.8% Asian) and clinical conditions (46% neurotypical, 31% stroke, 7% Parkinson’s disease, 6% orthopedic conditions, and others). The dataset is publicly available and accompanied by open source code and an app that allows for interaction with the data. This dataset will facilitate the use of sensor data to advance rehabilitation research and practice, improve the reproducibility and replicability of wearable sensor studies, and minimize costs and duplicated scientific efforts.
Obstructive Sleep Apnea is a Risk Factor for Incident COVID-19 Infection
Authors: Quan Stuart F. , Weaver Matthew D. , Czeisler Mark É. , Barger Laura K. , Booker Lauren A. , Howard Mark E. , Jackson Melinda L. , McDonald Christine F. , Ridgers Anna , Robbins Rebecca , Varma Prerna , Rajaratnam Shantha M.W. , Czeisler Charles A. 
Published: August 2024

AbstractCross-sectional studies suggest that obstructive sleep apnea (OSA) is a potential risk factor for incident COVID-19 infection, but longitudinal studies are lacking. In this study, two surveys from a large general population cohort, the COVID-19 Outbreak Public Evaluation (COPE) Initiative, undertaken 147 ± 58 days apart were analyzed to determine whether the pre-existing OSA was a risk factor for the incidence of COVID-19. Of the 24,803 respondents completing the initial survey, 14,950 were negative for COVID-19; data from the follow-up survey were available for 2,325 respondents. Those with incident COVID-19 infection had a slightly higher prevalence of OSA (14.3 vs. 11.5%, p=0.068). Stratification by treatment status revealed that those untreated for their OSA were at greater risk for developing COVID-19 infection (OSA Untreated, 14.2 vs. 7.4%, p≤0.05). In a logistic regression model adjusted for comorbidities, demographic and socioeconomic factors and the interaction between vaccination status and OSA, incident COVID-19 infection was 2.15 times more likely in those with untreated OSA (aOR: 2.15, 95% CI: 1.18-3.92, p≤0.05). Stratification by treatment status revealed only untreated OSA participants were at greater risk for COVID-19 (aOR: 3.21, 95% CI: 1.25-8.23, p≤0.05). The evidence from this study confirms untreated OSA as a risk factor for acquiring COVID-19 infection and highlights the importance of actively treating and managing OSA as a preventative mechanism against COVID-19 disease.