bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENINGKATAN VALUE UNIT BISNIS DAN TRAINING CENTER PNJ MELALUI KATALOG PROGRAM PELATIHAN BERBENTUK BUKU INTERAKTIF
Authors: Kusumaasri Resti Dyah , Putri Audrey Salsa Safiera Nindya , Halimah Maryam , Salam Muhammad Baits 
Published: July 2024

Abstrak
Kurangnya efektivitas pada media promosi Unit Bisnis dan Training Center Politeknik Negeri Jakarta (PNJ), membuat kehadirannya kurang dikenal masyarakat. Karena media promosi yang belum terkonsep dengan baik, sehingga isi konten hanya berupa tulisan yang disusun seperti surat formal. Untuk meningkatkan efektivitas media promosi, dirancanglah sebuah company profile berbentuk buku katalog pelatihan interaktif yang dapat meningkatkan interaksi penggunanya. Pada penelitian sebelumnya, belum adanya penggunaan fitur interaktif pada company profile atau katalog lembaga penyedia Jasa pelatihan. Tujuan penelitian ini adalah untuk menghasilkan katalog Unit Bisnis dan Training Center PNJ yang dapat meningkatkan value serta menambah nilai jual dan mitra kerja sama. Metode penelitian yang digunakan adalah penelitian kualitatif serta kuantitatif dengan analisis SWOT serta STP yang dilakukan dengan tahapan design thinking. Dengan demikian, dihasilkan Katalog Pelatihan Interaktif Unit Bisnis dan Training center PNJ yang disajikan dengan warna kontras dan layout berfokus pada foto yang diberi penjelasan sesuai dengan kebutuhan dari Unit Bisnis dan Training Center PNJ serta para penggunanya, sehingga dapat meningkatkan value Unit bisnis dan Training Center PNJ.

Kata Kunci: buku interaktif, katalog, media promosi

Abstract
The lack of effectiveness in the PNJ Business Unit and Training Center promotional media made its presence less well-known to the public. Due to the promotional media not being well conceptualized, the content is only in the form of writing, arranged like a formal letter. To increase the effectiveness of promotional media, a company profile was designed in the form of an interactive training catalog book that can increase user interaction. The research that has been conducted in the previous times, did not use interactive features on company profiles or catalogs of institutions providing training services. This research aims to produce a PNJ Business Unit and Training Center catalog that can increase its value, sales value, and cooperation partners. The method that is being used in this research is qualitative and quantitative research with SWOT analysis and STP that is carried out with design thinking stages. Thus, a PNJ Business Unit and PNJ Training Center Interactive Training Catalog is produced with colors that have good contrast and photo as main content that suits the needs of the PNJ Business Units and Training Centers and their users, so that they can increase the value of the PNJ Business Units and Training Centers.

Keywords: catalogue, interactive book, promotional media
A streamlined and adaptive approach for accrediting a French education system program by ABET-EAC
Authors: Barkaoui Abdelwahed , Ouldasine Radouane , Bettaibi Soufiene , Jamart-Gregoire Brigitte , Ezbakhe Ahmed 
Published: July 2024

IntroductionIn recent times, there has been a notable increase in the demand for accreditations, driven by their essential role in recognizing diplomas, elevating the quality of higher education, facilitating student mobility, enabling the pursuit of multiple degrees, and influencing university rankings. This surge in demand reflects the evolving landscape of higher education in a world that is becoming progressively interconnected and competitive.MethodsThis paper presents a comprehensive methodology for accrediting study programs in French higher education institutions worldwide that are seeking the Accreditation Board for Engineering and Technology (ABET) accreditation. ABET accreditation is a globally recognized organism of quality for education programs in engineering, computer science, and related fields. The methodology proposed in this paper focuses on aligning ABET’s requirements and standards with the specific context of the French Education System (FES). It provides clear guidelines and practical steps for higher education institutions to effectively navigate the accreditation process. The methodology covers the verification of existing study programs, identification of areas for improvement, implementation of corrective actions, and continuous progress monitoring. It emphasizes the importance of continuous improvement and aligning programs with the Program Educational Objectives (POEs). Concrete examples and best practices are shared to illustrate successful implementation of the methodology developed based on the example of the engineering college programs at our university.Results and discussionThe results obtained in this case study demonstrate the applicability and effectiveness of this approach within a specific educational context. The approach presented in this contribution can serve as a model for other countries seeking to adapt ABET accreditation requirements to their own higher education systems, further promoting diversity and openness. This reinforces the credibility of the methodology and paves the way for its use in other institutions and programs that operate within similar systems.
Cardiovascular autonomic and peripheral sensory neuropathy in women with obesity
Authors: Keller Nóra , Zádori János , Lippai Balázs , Szöllősi Dalma , Márton Virág , Wellinger Károly , Lada Szilvia , Szűcs Mónika , Menyhárt Adrienn , Kempler Péter , Baczkó István , Várkonyi Tamás , Lengyel Csaba , Vágvölgyi Anna 
Published: July 2024

IntroductionA higher incidence of neural dysfunction in people with obesity has been described. We determined the prevalence of neuropathic lesions in obese women and evaluated their potential association with anthropometric and laboratory parameters.Patients and methodsIn our cross-sectional study, we enrolled female patients with obesity and without diabetes before obesity treatment. Voluntary female subjects were controls with a normal body mass index (BMI). Autonomic function was assessed by Ewing’s cardiovascular reflex tests, while comprehensive peripheral neuropathic assessments were conducted utilizing the Neurometer®, Tiptherm®, Monofilament®, and Rydel-Seiffer tuning fork tests. Sudomotor function was assessed by the Neuropad®-test. Body composition was examined using the InBody 770.Results71 patients (mean ± SD; age: 36.1 ± 8.3 years; BMI: 40.2 ± 8.5 kg/m2) and 36 controls (age: 36.4 ± 13.3 years; BMI: 21.6 ± 2.1 kg/m2) were enrolled. Patients had significantly higher systolic (patients vs. controls; 137.5 ± 16.9 vs. 114.6 ± 14.8 mmHg, p&lt;0.001) and diastolic (83.0 ± 11.7 vs.69.8 ± 11.2 mmHg, p&lt;0.001) blood pressure compared to controls. Among autonomic tests, only the heart rate response to Valsalva maneuver (Valsalva-ratio) revealed significant impairment in patients (1.4 ± 0.2 vs. 1.7 ± 0.4, p&lt;0.001). Neurometer® at the median nerve revealed increased current perception threshold (CPT) values at all stimulating frequencies in patients (CPT at 2000 Hz: 204.6 ± 70.9 vs. 168.1 ± 66.9, p=0.013; 250 Hz: 84.4 ± 38.9 vs. 56.5 ± 34.8, p&lt;0.001; CPT at 5 Hz: 58.5 ± 31.2 vs 36.9 ± 29.1, p&lt;0.001). The Rydel-Seiffer tuning fork test has revealed a significant impairment of vibrational sensing on the lower limb in patients (right hallux: 6.8 ± 0.9 vs. 7.4 ± 0.8, p=0.030; left hallux: 6.9 ± 0.8 vs. 7.3 ± 0.9, p=0.029). The Neuropad® testing showed a significant impairment of sudomotor function in women with obesity. A negative correlation was found in patients between BMI and the 25-hydroxy-D3/D2-vitamin levels (r=-0.41, p=0.00126) and a positive correlation between the BMI and resting systolic blood pressure (r=0.26, p=0.0325).ConclusionPeripheral sensory neuronal and sudomotor function impairments were detected in female patients with obesity compared to the controls with normal BMI. Cardiovascular autonomic dysfunction was also revealed by the Valsalva-ratio in these patients, suggesting the presence of parasympathetic dysfunction. The negative correlation between BMI and the 25-hydroxy-D3/D2-vitamin highlights the potential deficiency of vitamin D in the population affected by obesity.
Thyroid dysfunction in the wake of Omicron: understanding its role in COVID-19 severity and mortality
Authors: Zhang Qingfeng , Zhang Zongyue , Liu Xu , Wang Yixuan , Chen Hao , Hao Yueying , Zha Shiqian , Zhang Jingyi , He Yang , Zhou Beini , Hu Ke 
Published: July 2024

PurposeSARS-CoV-2 can invade the thyroid gland. This study was to delineate the risk of thyroid dysfunction amidst the prevalence of the Omicron variant, and to investigate the correlation between thyroid function and Coronavirus disease 2019 (COVID-19) outcomes. The study also aimed to ascertain whether thyroid dysfunction persisted during COVID-19 recovery phase.MethodsThis was a retrospective cohort study. COVID-19 patients from the Renmin Hospital of Wuhan University, China during the epidemic of Omicron variants were included, and their thyroid function were analyzed in groups.ResultsA history of thyroid disease was not associated with COVID-19 outcomes. COVID-19 can lead to a bimodal distribution of thyroid dysfunction. The severity of COVID-19 was inversely proportional to the levels of thyroid- stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4), leading to a higher prevalence of thyroid dysfunction. Severe COVID-19 was a risk factor for euthyroid sick syndrome (ESS) (OR=22.5, 95% CI, 12.1 - 45.6). Neutrophil to lymphocyte ratio mediated the association between severe COVID-19 and ESS (mediation effect ratio = 41.3%, p &lt; 0.001). ESS and decreased indicators of thyroid function were associated with COVID-19 mortality, while high levels of FT3 and FT4 exhibited a protective effect against death. This effect was more significant in women (p &lt; 0.05). During the recovery period, hyperthyroidism was quite uncommon, while a small percentage of individuals (7.7%) continued to exhibit hypothyroidism.ConclusionCOVID-19 severity was linked to thyroid dysfunction. Severe COVID-19 increased the risk of ESS, which was associated with COVID-19 mortality. Post-recovery, hyperthyroidism was rare, but some individuals continued to have hypothyroidism.
Synergic effect of thermo-chemical pretreatment of waste-activated sludge on bio-methane enhancement
Authors: Almegbl A. M. , Munshi F. , Khursheed A. 
Published: July 2024

Sustainable and environmentally friendly energy production is feasible via anaerobic digestion (AD) of organic wastes, such as waste-activated sludge (WAS). However, due to its limited degradation, a pretreatment strategy is applied to WAS to enhance its bio-degradation and, thus, biogas yield. Alkaline (0.5%–9% g NaOH/gTS, 30 min), microwave (MW) (90°C–175°C), and hybrid (0.5% g NaOH/gTS +125°C) pretreatments were applied to WAS. The characterization of untreated and pretreated WAS revealed that with higher alkaline and MW pretreatment, the soluble chemical oxygen demand (sCOD), carbohydrate, and protein increased; however, the readily biodegradable COD (rbCOD) rate was unlike the sCOD. The sCOD was 7%–18%, 8%–23%, and 37% for alkaline, MW, and hybrid pretreatments, respectively. Stronger alkaline and MW pretreatment induced higher turbidity, capillary suction time, and lower average particle size. AD of alkaline-, MW-, and hybrid-pretreated WAS produced 94% (0.5% NaOH), 125% (MW at 125°C), and 199% (0.5% NaOH and MW at 125°C) increased biogas, respectively, compared to the AD of untreated sludge. The AD data on the alkaline-, MW-, and hybrid-pretreated BMP assays fitted well with the modified Gompertz model with a coefficient of determination above 0.95. The PCA analysis showed that biogas production is closely correlated with pretreatment temperature, VFA production, rbCOD, sCOD, and soluble carbohydrates and protein. Microbial genome sequencing analysis showed an improvement in microbial abundance and diversity. Acetoclastic methanogen (Methanothrix) growth was improved by 37% (MW pretreatment). Abundances of Methanosarcina, using all three metabolic pathways for methanogenesis, were 17, 21, 11, and 48% in the control, alkaline-, MW-, and hybrid-pretreated digestate, respectively, corresponding to 186% improvement in hybrid pretreatment when compared to the control.
Age-correlated changes in the canine oral microbiome
Authors: Kislik Gregory , Zhou Lin , Rubbi Liudmilla , Pellegrini Matteo 
Published: July 2024

IntroductionCanine oral disease has been associated with significant changes in the oral microbiome rather than the presence or absence of individual species. In addition, most studies focus on a single age group of canines and as of yet, the relationship between canine microbiomes and age is poorly understood.MethodsThis study used a shotgun whole gene sequencing approach in tandem with the Aladdin Bioinformatics platform to profile the microbiomes of 96 companion dogs, with the sourmash-zymo reference database being used to perform taxonomic profiling.ResultsFindings showed significant age correlations among 19 species, including positive correlations among several Porphyromonas species and a negative correlation with C. steedae. Although a significant correlation was found between predicted and actual ages, ElasticNet Regression was unable to successfully predict the ages of younger canines based on their microbiome composition. Both microbiome samples and microbial species were successfully clustered by age group or age correlation, showing that the age-microbiome relationship survives dimensionality reduction. Three distinct clusters of microbial species were found, which were characterized by Porphyromonas, Conchiformibius, and Prevotella genera, respectively.DiscussionFindings showed that the microbiomes of older dogs resembled those that previous literature attributed to dogs with periodontal disease. This suggests that the process of aging may introduce greater risks for canine oral disease.
Robust anti-tubercular profile of Solanum virginianum extract in enhancing isoniazid bioavailability and curtailing stress tolerance in Mycobacterium smegmatis
Authors: Balkrishna Acharya , Joshi Monali , Kabdwal Manisha , Tomer Meenu , Lochab Savita , Varshney Anurag 
Published: July 2024

IntroductionThe formidable survival mechanisms employed by Mycobacterium tuberculosis (Mtb), combined with the low bioavailability of anti-tubercular drugs and their associated hepatotoxicity, worsen tuberculosis management. Traditional medicinal plants offer potential solutions to these challenges. This study focuses on exploring the anti-tubercular potential of Solanum virginianum against Mycobacterium smegmatis, mc2155.Methods and resultsHPTLC and UHPLC phytochemically characterized the hydro-methanolic extract of Solanum virginianum (SVE). SVE curtails the growth and viability of mc2155 under normal and in vitro stress conditions. The compromised cell wall integrity of mc2155 with SVE is depicted through scanning electron microscopy (SEM) while EtBr permeability assays and TLC-based comparative changes in lipids extraction addressed the integrity of the cell wall. Furthermore, SVE augmented the susceptibility of mc2155 towards Isoniazid (INH) through enhanced bioavailability. Adjunct treatment of SVE with INH demonstrated a markedly reduced survival of the intracellular bacilli. The study also uncovered the hepatoprotective potential of SVE in HepG2 cells.ConclusionThis research paves the way for deeper exploration into the potential of Solanum virginianum against virulent Mtb strains, emphasizing over the significance of traditional medicinal plants in tuberculosis treatment. Collectively, the findings suggest SVE as a potent candidate for independent or adjunct anti-tubercular therapy.
Incidence and influencing factors of olfactory dysfunction in patients 1 week after endoscopic transsphenoidal resection of pituitary tumor: a cross-sectional study of 158 patients
Authors: Zhou Sumei , Zeng Zhi , Chen Min , Zou Linbo , Shao Shirong 
Published: July 2024

ObjectiveTo investigate the current situation of olfactory dysfunction in patients after endoscopic transsphenoidal resection of pituitary tumors, and analyze its influencing factors, to provide references for clinical nursing and rehabilitation.MethodsA cross-sectional study design and convenience sampling method were used to investigate 158 patients with pituitary tumors treated by endoscopic transsphenoidal pituitary tumor resection in the Department of Neurosurgery of three Grade-A general hospitals in Sichuan Province from January 2022 and June 2023. The olfactory function of patients was evaluated 1 week after surgery, and the general clinical data and olfactory related data of patients were collected, and the influencing factors of olfactory disorder were analyzed by logistic regression.ResultsThe incidence of olfactory dysfunction was 73.42%. analysis revealed that the formation of blood scabs, nasal cavity adhesion, cerebrospinal fluid leakage and operation time were independent risk factors for olfactory dysfunction in patients after transsphenoidal pituitary tumor resection (p &lt; 0.05).ConclusionThe incidence of olfactory dysfunction is high in patients after endoscopic transsphenoidal resection of pituitary tumors, suggesting that medical staff should pay close attention to and identify patients with olfactory dysfunction based on the guidance of disease knowledge and skills, develop targeted nursing interventions, and promote the improvement of patients’ olfactory function and quality of life.
A novel minimally invasive and versatile kyphoplasty balloon-based model of porcine spinal cord injury
Authors: Barber Sean M. , Wolfe Tatiana , Steele Alexander G. , Hoffman Kris , Hogan Matthew K. , Frazier Allison , Tang Xiufeng , Sayenko Dimitry G. , Horner Philip J. 
Published: July 2024

IntroductionSpinal cord injury (SCI) animal models often utilize an open surgical laminectomy, which results in animal morbidity and also leads to changes in spinal canal diameter, spinal cord perfusion, cerebrospinal fluid flow dynamics, and spinal stability which may confound SCI research. Moreover, the use of open surgical laminectomy for injury creation lacks realism when considering human SCI scenarios.MethodsWe developed a novel, image-guided, minimally invasive, large animal model of SCI which utilizes a kyphoplasty balloon inserted into the epidural space via an interlaminar approach without the need for open surgery.ResultsThe model was validated in 5 Yucatán pigs with imaging, neurofunctional, histologic, and electrophysiologic findings consistent with a mild compression injury.DiscussionFew large animal models exist that have the potential to reproduce the mechanisms of spinal cord injury (SCI) commonly seen in humans, which in turn limits the relevance and applicability of SCI translational research. SCI research relies heavily on animal models, which typically involve an open surgical, dorsal laminectomy which is inherently invasive and may have untoward consequences on animal morbidity and spinal physiology that limit translational impact. We developed a minimally invasive, large animal model of spinal cord injury which utilizes a kyphoplasty balloon inserted percutaneously into the spinal epidural space. Balloon inflation results in a targeted, compressive spinal cord injury with histological and electrophysiological features directly relevant to human spinal cord injury cases without the need for invasive surgery. Balloon inflation pressure, length of time that balloon remains inflated, and speed of inflation may be modified to achieve variations in injury severity and subtype.
Alpha and theta oscillations on a visual strategic processing task in age-related hearing loss
Authors: Shende Shraddha A. , Jones Sarah E. , Mudar Raksha A. 
Published: July 2024

IntroductionEmerging evidence suggests changes in several cognitive control processes in individuals with age-related hearing loss (ARHL). However, value-directed strategic processing, which involves selectively processing salient information based on high value, has been relatively unexplored in ARHL. Our previous work has shown behavioral changes in strategic processing in individuals with ARHL. The current study examined event-related alpha and theta oscillations linked to a visual, value-directed strategic processing task in 19 individuals with mild untreated ARHL and 17 normal hearing controls of comparable age and education.MethodsFive unique word lists were presented where words were assigned high- or low-value based on the letter case, and electroencephalography (EEG) data was recorded during task performance.ResultsThe main effect of the group was observed in early time periods. Specifically, greater theta synchronization was seen in the ARHL group relative to the control group. Interaction between group and value was observed at later time points, with greater theta synchronization for high- versus low-value information in those with ARHL.DiscussionOur findings provide evidence for oscillatory changes tied to a visual task of value-directed strategic processing in individuals with mild untreated ARHL. This points towards modality-independent neurophysiological changes in cognitive control in individuals with mild degrees of ARHL and adds to the rapidly growing literature on the cognitive consequences of ARHL.
Association between different composite dietary antioxidant indexes and constipation in American male adults: a cross-sectional study
Authors: Sun Wei , Wang Yuchao , Han Lu , Liu Yinshi , Liu Hongru , Tong Yunbing , Jiang Ziying , Xu Chen , Sun Daqing 
Published: July 2024

BackgroundOxidative stress is acknowledged as a pivotal factor in the intricate pathophysiological processes and pathogenesis of constipation. Modifying dietary patterns can elevate in vivo antioxidant biomarker levels, consequently mitigating oxidative stress. The Composite Dietary Antioxidant Index (CDAI) provides a dependable scoring mechanism for quantifying the potential antioxidant capacity of diets. The association between CDAI levels and the risk of constipation remains uncertain.PurposeTo investigate the potential correlation between CDAI and constipation, aiming to improve constipation management through dietary guidance.MethodsA total of 11,165 adults aged ≥20 years, drawn from the 2005–2010 National Health and Nutrition Examination Survey, were enrolled in this cross-sectional study. We evaluated the correlation between CDAI levels and the risk of constipation through three weighted logistic regression models. Restricted cubic spline (RCS) analysis was employed to assess nonlinear trends, and stratified analyses were conducted.ResultsAfter adjusting for all confounding variables, the findings revealed an association between CDAI and constipation [OR = 0.937; 95% CI (0.892, 0.984), p = 0.012]. Moreover, individuals in the highest quartile of CDAI demonstrated a 40.1% lower likelihood of experiencing constipation compared to those in the lowest quartile [OR = 0.599; 95% CI (0.382, 0.939), p = 0.027]. The RCS analysis indicated a linear relationship between CDAI and constipation (P-non-linear =0.1016). Subgroup analysis by gender revealed a negative correlation in the male population [OR = 0.871; 95% CI (0.801, 0.947), p = 0.002], with men in the highest CDAI quartile exhibiting a 59.8% lower likelihood of experiencing constipation compared to those in the lowest quartile [OR = 0.402; 95% CI (0.206, 0.787), p = 0.010]. Furthermore, alterations in selenium [OR = 0.997; 95% CI (0.995, 1.000), p = 0.039] per milligram were independently linked to constipation. In a gender subgroup analysis of a single antioxidant, changes per milligram of vitamin E [OR = 0.904; 95% CI (0.838 to 0.975), p = 0.011] among males were independently associated with constipation.ConclusionThe fully adjusted model showed a correlation between CDAI and constipation and a significant correlation in quartiles. Meanwhile, subgroup analysis by gender showed that CDAI was negatively associated with constipation in the male population. Moreover, the findings of this study imply that investigations into antioxidant diets should be contextualized within dietary patterns.