bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetically Separable Fe3O4/AgBr Hybrid Materials: Highly Efficient Photocatalytic Activity and Good Stability
Authors: Cao Yuhui , Li Chen , Li Junli , Li Qiuye , Yang Jianjun 
Published: June 2015

Abstract
Magnetically separable Fe3O4/AgBr hybrid materials with highly efficient photocatalytic activity were prepared by the precipitation method. All of them exhibited much higher photocatalytic activity than the pure AgBr in photodegradation of methyl orange (MO) under visible light irradiation. When the loading amount of Fe3O4 was 0.5 %, the hybrid materials displayed the highest photocatalytic activity, and the degradation yield of MO reached 85 % within 12 min. Silver halide often suffers serious photo-corrosion, while the stability of the Fe3O4/AgBr hybrid materials improved apparently than the pure AgBr. Furthermore, depositing Fe3O4 onto the surface of AgBr could facilitate the electron transfer and thereby leading to the elevated photocatalytic activity. The morphology, phase structure, and optical properties of the composites were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV–visible diffuse reflectance spectra (UV–vis DRS), and photoluminescence (PL) techniques.
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells
Authors: Yuan Jie , Liu Manran , Yang Li , Tu Gang , Zhu Qing , Chen Maoshan , Cheng Hong , Luo Haojun , Fu Weijie , Li Zhenhua , Yang Guanglun 
Published: June 2015

Abstract
Introduction
Acquired tamoxifen resistance remains the major obstacle to breast cancer endocrine therapy. β1-integrin was identified as one of the target genes of G protein-coupled estrogen receptor (GPER), a novel estrogen receptor recognized as an initiator of tamoxifen resistance. Here, we investigated the role of β1-integrin in GPER-mediated tamoxifen resistance in breast cancer.

Methods
The expression of β1-integrin and biomarkers of epithelial-mesenchymal transition were evaluated immunohistochemically in 53 specimens of metastases and paired primary tumors. The function of β1-integrin was investigated in tamoxifen-resistant (MCF-7R) subclones, derived from parental MCF-7 cells, and MCF-7R β1-integrin-silenced subclones in MTT and Transwell assays. Involved signaling pathways were identified using specific inhibitors and Western blotting analysis.

Results
GPER, β1-integrin and mesenchymal biomarkers (vimentin and fibronectin) expression in metastases increased compared to the corresponding primary tumors; a close expression pattern of β1-integrin and GPER were in metastases. Increased β1-integrin expression was also confirmed in MCF-7R cells compared with MCF-7 cells. This upregulation of β1-integrin was induced by agonists of GPER and blocked by both antagonist and knockdown of it in MCF-7R cells. Moreover, the epidermal growth factor receptor/extracellular regulated protein kinase (EGFR/ERK) signaling pathway was involved in this transcriptional regulation since specific inhibitors of these kinases also reduced the GPER-induced upregulation of β1-integrin. Interestingly, silencing of β1-integrin partially rescued the sensitivity of MCF-7R cells to tamoxifen and the α5β1-integrin subunit is probably responsible for this phenomenon. Importantly, the cell migration and epithelial-mesenchymal transition induced by cancer-associated fibroblasts, or the product of cancer-associated fibroblasts, fibronectin, were reduced by knockdown of β1-integrin in MCF-7R cells. In addition, the downstream kinases of β1-integrin including focal adhesion kinase, Src and AKT were activated in MCF-7R cells and may be involved in the interaction between cancer cells and cancer-associated fibroblasts.

Conclusions
GPER/EGFR/ERK signaling upregulates β1-integrin expression and activates downstream kinases, which contributes to cancer-associated fibroblast-induced cell migration and epithelial-mesenchymal transition, in MCF-7R cells. GPER probably contributes to tamoxifen resistance via interaction with the tumor microenvironment in a β1-integrin-dependent pattern. Thus, β1-integrin may be a potential target to improve anti-hormone therapy responses in breast cancer patients.
nab-Paclitaxel dose and schedule in breast cancer
Authors: Martín Miguel 
Published: June 2015

Abstractnab-Paclitaxel is approved for the treatment of metastatic breast cancer on an every-3-week schedule based on positive findings from a pivotal phase III trial in which nab-paclitaxel 260 mg/m2 every 3 weeks was superior to solvent-based paclitaxel 175 mg/m2 every 3 weeks for the primary endpoint of overall response rate (33 % vs 19 %; P = 0.001). Subsequently, a number of trials have examined different schedules, doses, and combinations in efforts to optimize nab-paclitaxel-based therapy for metastatic and early-stage breast cancer. The goal of this review is to evaluate the clinical experiences to date with nab-paclitaxel as a single agent or in combination with targeted agents in different treatment settings - with a focus on the feasibility of administration, adverse event profile, and standard efficacy endpoints, such as overall survival, progression-free survival, overall response rate, and pathologic complete response rate. In general, weekly dosing during the first 3 of 4 weeks appears to achieve the best clinical benefit in both the metastatic and early-stage settings. Furthermore, the data suggest that high doses of nab-paclitaxel, such as 150 mg/m2 during first 3 of 4 weeks or 260 mg/m2 every 2 weeks, may be more feasible and appropriate for treatment of early-stage disease compared with metastatic disease. Intense regimens of nab-paclitaxel may not be the best treatment approach for unselected patients with metastatic breast cancer, but may suit a subset of patients for whom immediate disease control is required. The growing number of nab-paclitaxel trials in breast cancer will lead to greater refinements in tailoring therapy to patients based on their individual disease and patient characteristics.
High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium
Authors: Huo Cecilia W. , Chew Grace , Hill Prue , Huang Dexing , Ingman Wendy , Hodson Leigh , Brown Kristy A. , Magenau Astrid , Allam Amr H. , McGhee Ewan , Timpson Paul , Henderson Michael A. , Thompson Erik W. , Britt Kara 
Published: June 2015

Abstract
Introduction
Mammographic density (MD), after adjustment for a women’s age and body mass index, is a strong and independent risk factor for breast cancer (BC). Although the BC risk attributable to increased MD is significant in healthy women, the biological basis of high mammographic density (HMD) causation and how it raises BC risk remain elusive. We assessed the histological and immunohistochemical differences between matched HMD and low mammographic density (LMD) breast tissues from healthy women to define which cell features may mediate the increased MD and MD-associated BC risk.

Methods
Tissues were obtained between 2008 and 2013 from 41 women undergoing prophylactic mastectomy because of their high BC risk profile. Tissue slices resected from the mastectomy specimens were X-rayed, then HMD and LMD regions were dissected based on radiological appearance. The histological composition, aromatase immunoreactivity, hormone receptor status and proliferation status were assessed, as were collagen amount and orientation, epithelial subsets and immune cell status.

Results
HMD tissue had a significantly greater proportion of stroma, collagen and epithelium, as well as less fat, than LMD tissue did. Second harmonic generation imaging demonstrated more organised stromal collagen in HMD tissues than in LMD tissues. There was significantly more aromatase immunoreactivity in both the stromal and glandular regions of HMD tissues than in those regions of LMD tissues, although no significant differences in levels of oestrogen receptor, progesterone receptor or Ki-67 expression were detected. The number of macrophages within the epithelium or stroma did not change; however, HMD stroma exhibited less CD206+ alternatively activated macrophages. Epithelial cell maturation was not altered in HMD samples, and no evidence of epithelial–mesenchymal transition was seen; however, there was a significant increase in vimentin+/CD45+ immune cells within the epithelial layer in HMD tissues.

Conclusions
We confirmed increased proportions of stroma and epithelium, increased aromatase activity and no changes in hormone receptor or Ki-67 marker status in HMD tissue. The HMD region showed increased collagen deposition and organisation as well as decreased alternatively activated macrophages in the stroma. The HMD epithelium may be a site for local inflammation, as we observed a significant increase in CD45+/vimentin+ immune cells in this area.
Education and microfinance: an alternative approach to the empowerment of the poor people in Indonesia
Authors: Hadi Rizali , Wahyudin Uyu , Ardiwinata Jajat S , Abdu Wamaungo Juma 
Published: June 2015

Abstract
There is good reason to combine education with microcredit for poverty alleviation in the poor communities of the developing world, including in Indonesia. Poverty is dangerous, it deprives people of their right to education, their right to good health, their right to freedom of speech, their right to democracy, their right to financial services and of course their right to knowledge enhancement, which are all crucial to living a better life. We must therefore, provide services beyond, credits for the poor. In this case, education should be included to each and every development agenda for the poor since it is key to any positive change and sustainable development of people. If well planned and well integrated within the microcredit services, education can serve a good purpose in poverty alleviation. This paper describes how education and microfinance have been used in combination to alleviate poverty in Indonesia, especially in the areas studied. The study uses a multi-cases approach to examine the purposively selected baitul maal tamwil (BMTs) organisations, which are sharia based semiformal microfinance institutions regarded to be among those few integrating education with their financial services.
Self organization based energy management techniques in mobile complex networks: a review
Authors: Fatima Bahjat , Shah Munam Ali 
Published: June 2015

Abstract
Today’s mobile devices offer a variety of computational, memory, storage, communication and sensing resources. In addition, mobile communication technologies are continuously evolving and mobile networks are becoming more and more complex. Modern mobile devices are capable of supporting a wide range of new innovative applications from real-time location-based tracking to mobile gaming. However, the usage of power-hungry applications, sensors and their demand for 24/7 Internet connectivity requires an efficient energy management mechanism in mobile devices. With the increasing energy limitations, there has been a corresponding rise of energy management solutions proposed by researchers. However, this research area is still immature and existing literature lacks the critical review of recent self organization based energy management techniques. This paper aims to provide a structured overview of the research developments on self organization based energy management techniques used in mobile complex networks. This review paper surveys the state-of-the-art self organization based energy management techniques that have been proposed over the period of 2010–2015. Based on the proposed optimization, we have grouped the existing approaches in different categories, which are further classified at different levels, from energy-efficient operating systems to computation off-loading. With this classification we aim to provide an easy and summarized view of the latest self organization based energy management techniques that can be implemented in mobile devices.
Effect of non-surgical maxillary expansion on the nasal septum deviation: a systematic review
Authors: Aziz Tehnia , Ansari Kal , Lagravere Manuel O. , Major Michael P. , Flores-Mir Carlos 
Published: June 2015

Abstract
Nasal breathing is a requirement for proper growth and development of the craniofacial complex. Inadequacy of the nasal airway from obstruction such as from nasal septal deviation (NSD) can affect craniofacial development. Further investigation of the possibility of rapid maxillary expansion (RME) correcting NSD would be valuable, considering the undesirable sequelae of NSD on nasal breathing, which can consequently affect craniofacial development. A systematic review of the effect of RME treatment on NSD was conducted. Electronic database searches were conducted until April 2015 using MEDLINE, EMBASE, Web of Science, Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CCTR), Cochrane Methodology Register (CMR), Database of Abstracts of Reviews of Effects (DARE), American College of Physicians Journal Club (ACP Journal Club), Health Technology Assessments (HTA), and NHS Economic Evaluation Database (NHSEED). MeSH terms used in database searches were ‘nasal septum,’ ‘palatal expansion,’ and ‘maxillary expansion,’ ‘orthodontic device,’ and ‘palatal expansion technique.’ The methodological quality of studies was reviewed using methodological index for non-randomized studies (MINORS). Only two studies were finally selected and reviewed. Both studies had significant methodological limitations. One study reported a significant straightening of the nasal septum in the middle and the inferior third of nasal cavity from RME in children aged 5 to 9 years. The other study reported no positional change in the nasal septum from RME in adolescent orthodontic patients. Thus far, the limited available (moderate risk of bias) evidence suggests a potentially positive effect on the nasal septum asymmetry during childhood, but no significant change in adolescence from RME in patients with NSD. The clinical significance of reported changes could be considered questionable.
Avian thermoregulation in the heat: scaling of heat tolerance and evaporative cooling capacity in three southern African arid-zone passerines
Authors: Whitfield Maxine C. , Smit Ben , McKechnie Andrew E. , Wolf Blair O. 
Published: June 2015

ABSTRACT
Many birds can defend body temperature (Tb) far below air temperature (Ta) during acute heat exposure, but relatively little is known about how avian heat tolerance and evaporative cooling capacity varies with body mass (Mb), phylogeny or ecological factors. We determined maximum rates of evaporative heat dissipation and thermal end points (Tb and Ta associated with thermoregulatory failure) in three southern African ploceid passerines, the scaly-feathered weaver (Sporopipes squamifrons, Mb≈10 g), sociable weaver (Philetairus socius, Mb≈25 g) and white-browed sparrow-weaver (Plocepasser mahali, Mb≈40 g). Birds were exposed to a ramped profile of progressively increasing Ta, with continuous monitoring of behaviour and Tb used to identify the onset of severe hyperthermia. The maximum Ta birds tolerated ranged from 48°C to 54°C, and was positively related to Mb. Values of Tb associated with severe heat stress were in the range of 44 to 45°C. Rates of evaporative water loss (EWL) increased rapidly when Ta exceeded Tb, and maximum evaporative heat dissipation was equivalent to 141–222% of metabolic heat production. Fractional increases in EWL between Ta&lt;40°C and the highest Ta reached by each species were 10.8 (S. squamifrons), 18.4 (P. socius) and 16.0 (P. mahali). Resting metabolic rates increased more gradually with Ta than expected, probably reflecting the very low chamber humidity values we maintained. Our data suggest that, within a taxon, larger species can tolerate higher Ta during acute heat stress.
One-pot Optical Sensing of Keto Acids through the Combination of the Oxime-click Reaction and Aggregation-induced Emission (AIE)
Authors: Yoshihara Daisuke , Noguchi Takao , Tsuchiya Youichi , Roy Bappaditya , Yamamoto Tatsuhiro , Shinkai Seiji 
Published: June 2015

Abstract
Keto acids play important roles in vivo. In this paper, a novel one-pot keto acid detection system has been developed by the combination of the oxime-click reaction and aggregation-induced emission (AIE). Particularly high selectivity was observed for pyruvic acid (α-keto acid), but wide applications for sensing other keto acids are also possible by controlling the reaction conditions.
Size Control of ZnO Tetrapod in Gas-phase Synthesis using Flow Restrictor
Authors: Uchida Yoshiaki , Sakai Ken , Yamamoto Kaho , Nishiyama Norikazu 
Published: June 2015

Abstract
Monodispersed tetrapod-shaped ZnO (T-ZnO) particles with rods ranging from 1.3 to 10.5 µm are synthesized by gas-phase reaction of zinc vapor and oxygen gas using a flow restrictor in a single baking furnace. The size control of the T-ZnO particles is accomplished by changing the calcination time and the position of the flow restrictor.
Cytotoxic Metabolites Produced by the Endophytic Fungus Aspergillus clavatus
Authors: Wang Jiaming , Bai Gang , Liu Yihan , Wang Hongbin , Li Yu , Yin Wanqiang , Wang Yonglu , Lu Fuping 
Published: June 2015

Abstract
A new spiro azaphilone derivative, aspergillusone C (1), and a new cadinane-type sesquiterpenoid, aspergillusone D (2), together with a known azaphilone, felinone A (3), were isolated from the endophytic fungus Aspergillus clavatus. The structures of the new compounds were elucidated by NMR spectroscopy and electron circular dichroism data. Compound 2 exhibited detectable cytotoxic activity against two cell lines (MCF-7 and A549), with IC50 values of 5.9 and 0.2 µM, respectively, in the MTT assay.
Discovery of the Reduced Form of Methylviologen Activating Formate Dehydrogenase in the Catalytic Conversion of Carbon Dioxide to Formic Acid
Authors: Amao Yutaka , Ikeyama Shusaku 
Published: June 2015

Abstract
The kinetic properties of the conversion of CO2 to formic acid with formate dehydrogenase (FDH) using dithionite-reduced methylviologen as an artificial coenzyme were studied. The catalytic production of CO2 from formic acid by FDH was suppressed using methylviologen as an artificial coenzyme. In contrast, compared to the natural coenzyme NADH, dithionite-reduced methylviologen was a more effective coenzyme in the conversion of CO2 to formic acid with FDH.
Is MTHFD1 polymorphisms rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis
Authors: Zhao Huaxiang , Zhang Jieni , Zhang Mengqi , Deng Feng , Zheng Leilei , Zheng Hui , Chen Feng , Lin Jiuxiang 
Published: June 2015

Aims: To investigate the association between the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) polymorphism rs 2236225 (c.1958G>A) and susceptibility to non-syndromic cleft of the lip and/or palate (NSCL/P).Methods: An extensive literature review has been conducted using PubMed, Web of Science, Cochrane Library, Google Scholar, the China National Knowledge Infrastructure (CNKI), and Wanfang Database for eligible researches. The terms for searching were “cleft lip OR cleft palate OR CLP OR CL/P OR oral facial cleft OR OFC” AND “methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 OR methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase OR MTHFD1 OR MTHFD”. Two independent researchers screened, evaluated and extracted the data of included studies. The pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated by random effects model under five gene models. Subgroup, sensitivity analysis and publication bias were also assessed.Results: Ten case-control studies have been included in the systematic review and eight studies have been considered for the meta-analysis. Overall, the MTHFD1 polymorphism rs2236225 and the risk of NSCL/P showed pooled OR (95% CI) of 1.02 (0.86-1.21) under allelic model. A higher degree of heterogeneity was observed in Asian countries (I2 = 75.6%) compared to non-Asian countries (I2 = 48.9%). Similar consequence appeared in the subgroup of children (I2 = 78.6%) compared with that of mothers (I2 = 0.0%). There was no significant difference in the publication bias by the Begg’s funnel plot (P = 0.711) and Egger’s regression test (P = 0.746).Conclusion: Our assessment suggested there was no significant association between the MTHFD1 polymorphism rs 2236225 (c.1958G>A) and the susceptibility to NSCL/P. Further investigations using a large sample size and a more advanced technique should be adopted to reach a more precise conclusion in the future.
Queering, gazing and containment in Giovanni’s Room
Authors: Bloom James D. 
Published: June 2015

Abstract
This article traces the relationship among three ubiquitous critical terms and the ostensibly disparate concepts they encompass: containment, intervention and the male gaze. Though these terms became prevalent late in the twentieth century, when they began to pervade ‘literary theory’, my article demonstrates how James Baldwin’s 1956 novel, Giovanni’s Room, proleptically lays the ground work for the interplay among these concepts and how Baldwin remained preoccupied both avant la lettre and throughout his career, as a novelist, critic and polemicist, with many of the questions that late twentieth-century-intellectuals, literary theorists, feminist critics addressed, including Salman Rushdie, Fredric Jameson, Laura Mulvey, Eve Kosofsky Sedgwick, Cornel West and John Gaddis. In providing a context for the evolution of these preoccupations, this argument also highlights some of Baldwin’s formative influences and connections among such contemporaries of his as Norman Mailer, Wilhelm Reich and Lionel Trilling.
Reviews
Authors: Redgate Jamie P. , Tannenbaum Seth 
Published: June 2015

Abstract
Twenty-first-century Fiction: A Critical Introduction, Peter Boxall (2013) Cambridge: Cambridge University Press, 282 pp., (pbk) £15.99; ISBN-13: 9780521187299 (hbk) £45
The Nicest Kids in Town: American Bandstand, Rock ‘n’ Roll, and the Struggle for Civil Rights in 1950s Philadelphia, Matthew Delmont (2012) Berkley and Los Angeles: University of California Press, xi, 294 pp., ISBN: 9780520272088 (pbk) $29.95
Reorienting scarlet letters: Suzan-Lori Parks’ and Marina Carr’s Hester plays
Authors: O’Gorman Siobhán 
Published: June 2015

Abstract
This article considers the figure of Hester from Nathaniel Hawthorne’s The Scarlet Letter (1850) and its adaptation to contemporary African American and Irish dramatic writing. It focuses on In the Blood (1999) and Fucking A (2001) by African American playwright Suzan-Lori Parks, as well as Irish dramatist Marina Carr’s By the Bog of Cats … (1998). These theatre-makers consciously manipulate The Scarlet Letter in that each Hester figure is a racially different and already marginalized woman who goes on to murder her child. Drawing on the work of Sara Ahmed, I argue that Parks and Carr combine complex and overlapping processes of adaptation to expose the slippery relationship between signification and affect, and to reveal how affective economies shape and control racial and gendered bodies as well as their movements in space. In doing so, these dramatists call into question accepted conventions of judgement, justice and morality. Through processes of domestication, recontextualization and actualization, Parks and Carr engage complexly with hotly debated issues within their individual national contexts and in the wider, western milieu that they share.