bluuebunny/crossref_metadata_2025_split huggingface dataset:
CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection
Authors: Shaheen Zachary R. , Naatz Aaron , Corbett John A. 
Published: September 2015

Abstract
Encephalomyocarditis virus (EMCV) infection of macrophages results in the expression of a number of inflammatory and antiviral genes, including inducible NO synthase (iNOS) and cyclooxygenase (COX)-2. EMCV-induced macrophage activation has been shown to require the presence of CCR5 and the activation of PI3K-dependent signaling cascades. The purpose of this study was to determine the role of PI3K in regulating the macrophage responses to EMCV. We show that PI3K regulates EMCV-stimulated iNOS and COX-2 expression by two independent mechanisms. In response to EMCV infection, Akt is activated and regulates the translation of iNOS and COX-2 through the mammalian target of rapamycin complex (mTORC)1. The activation of mTORC1 during EMCV infection is CCR5-dependent and appears to function in a manner that promotes the translation of iNOS and COX-2. CCR5-dependent mTORC1 activation functions as an antiviral response, as mTORC1 inhibition increases the expression of EMCV polymerase. PI3K also regulates the transcriptional induction of iNOS and COX-2 in response to EMCV infection by a mechanism that is independent of Akt and mTORC1 regulation. These findings indicate that macrophage expression of the inflammatory genes iNOS and COX-2 occurs via PI3K- and Akt-dependent translational control of mTORC1 and PI3K-dependent, Akt-independent transcriptional control.
Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells
Authors: Zhang Baojun , Wu Jianxuan , Jiao Yiqun , Bock Cheryl , Dai Meifang , Chen Benny , Chao Nelson , Zhang Weiguo , Zhuang Yuan 
Published: September 2015

Abstract
Dendritic epidermal T cells (DETCs) are generated exclusively in the fetal thymus and maintained in the skin epithelium throughout postnatal life of the mouse. DETCs have restricted antigenic specificity as a result of their exclusive usage of a canonical TCR. Although the importance of the TCR in DETC development has been well established, the exact role of TCR signaling in DETC homeostasis and function remains incompletely defined. In this study, we investigated TCR signaling in fully matured DETCs by lineage-restricted deletion of the Lat gene, an essential signaling molecule downstream of the TCR. We found that Lat deletion impaired TCR-dependent cytokine gene activation and the ability of DETCs to undergo proliferative expansion. However, linker for activation of T cells–deficient DETCs were able to maintain long-term population homeostasis, although with a reduced proliferation rate. Mice with Lat deletion in DETCs exhibited delayed wound healing accompanied by impaired clonal expansion within the wound area. Our study revealed differential requirements for TCR signaling in homeostatic maintenance of DETCs and in their effector function during wound healing.
Pre-existent Training: Opportunities to Increase the Success Rate of ERP Systems Implementations for Sustainable Development Business
Authors: Bresfelean Vasile Paul , Res Moreno-Doru , Comes Calin-Adrian 
Published: September 2015

<p>The method described in this article is the result of authors' own experience in implementing ERP systems in the process industry for sustainable development business. Founded on this means, authors wish to significantly raise the low success rate of ERP implementations, according to the research literature. The article encompasses an analysis of information systems' methodology for implementation, together with highlights of resource-intensive areas and possible implementation failures. The novelty of our proposal is an initial module of pre-existent training (just before the system analysis phase in the project life cycle implementation) based on a standard model, the same model that was verified by the supplier, satisfying client requirements contained in the technical specifications manual. In the last part, there are presented the advantages and disadvantages in utilizing this method for the two ERP implicated parts: system provider and beneficiary. </p>
National en European champions: moet een hierop gericht industriebeleid onder de Europese concentratiecontroleregels als illusoir worden beschouwd?
Authors: Jansen Pim 
Published: September 2015

National en European champions: moet een hierop gericht industriebeleid onder de Europese concentratiecontroleregels als illusoir worden beschouwd?
De vergaande overheidsbemoeienis in het kader van de overnamestrijd rondom Alstom en AstraZeneca roept de vraag op of er in een Europese context juridisch gezien nog ruimte is voor een industriebeleid dat is gericht op het creëren, ondersteunen of beschermen van European en national champions. In dit artikel wordt deze vraag benaderd vanuit de Europese concentratiecontroleregels. Voor zover het gewenste beleid niet reeds op grond van de materiële toets in de CoVo kan worden verwezenlijkt, wordt ingegaan op de vraag welke mechanismen de CoVo bevat om te bepalen of, en zo ja, wanneer de mededinging in dat verband zou moeten wijken.
Markt en Overheid gestrand in het zicht van de Aanloophaven?
Authors: Kreijger Paul 
Published: September 2015

Markt en overheid gestrand in het zicht van de Aanloophaven?
In het eerste besluit van ACM sinds het volledig in werking treden van de Wet markt en overheid verklaart zij voor recht dat de gemeente Zeewolde in strijd heeft gehandeld met het gebod van kostendoorberekening (art. 25j Mw) bij de verhuur van ligplaatsen in de ‘Aanloophaven’. De gemeente probeert ACM de wind uit de zeilen te nemen door een algemeenbelangbesluit te nemen op grond van artikel 25h lid 6 Mw. De intrigerende vraag is of dat ook met terugwerkende kracht tot 1 juli 2014 kan, zoals de gemeente stelt en ACM – begrijpelijkerwijze – betwist.
Testimonio, Subjetividad y lenguajes femeninos en contextos de violencia política en América Latina
Authors: Cecilia Herrera Martha , Pertuz Bedoya Carol 
Published: September 2015

Resumen: En el marco del proyecto de investigación Narrativa Testimonial, Políticas de la Memoria y Subjetividad en América Latina, el presente artículo lleva a cabo algunas reflexiones sobre un corpus documental basado en textos escritos por mujeres que hicieron parte de grupos de izquierda que optaron por la vía armada entre los años 60 y 90 del siglo pasado. Con ello se busca iluminar los modos como la violencia política y el terrorismo de estado modularon la cultura política en América Latina e incidieron en la configuración de las subjetividades de quienes fueron actores directos o indirectos de dichos acontecimientos, al tiempo que se explora en dichas narrativas algunas de sus implicaciones sobre el tiempo presente. Palabras claves: Violencia política/subjetividades políticas/Narrativa testimonial/ Feminine Languages and Subjectivation. Annotations on Political Violence and Testimonial Narrative Abstract: In the framework of the research project Testimonial Narrative, Policies of Memory and Subjectivity in Latin America, this paper reflects on a documentary corpus based on texts written by women who once belonged to leftist groups opting for the arms between the 60’s and the 70´s in the 1900’s. Through this, we aim at enlightening the ways in which political violence and State terrorism modulated political culture in Latin America and affected the configuration of the subjectivities of direct or indirect actors in these events. At the same time, the paper explores some of the implications for the present time in these narratives. Key words: Political violence, political subjectivities, testimonial narratives
Pañoletas y polainas. Dinámicas de la moda en la Cuba soviética
Authors: Cabrera Arús Maria Antonia 
Published: September 2015

Resumen: El texto explora el rol de las dinámicas de la moda en la consolidación del socialismo de estado de tipo soviético en Cuba. Se afirma que la moda participó de dinámicas de dominación, legitimación y control en los años 1960s y 1970s. Se sostiene que el régimen cubano promovió significados denotativos de la cultura material que conectaron de manera directa valores políticos y estilos de la moda, y se ofrecen ejemplos que acercan el estudio de este país a los estudios contemporáneos de la cultura material en Europa del Este y la URSS. Palabras claves: cultura material, moda, significados denotativos, socialismo, Cuba Abstract: The text explores the role that fashion dynamics played in the consolidation of a Soviet-type state socialist regime in Cuba, where they participated of mechanisms of domination, legitimation, and control. It is argued that denotative understandings of material culture were promoted by the Cuban regime, which straightforwardly connected political values with fashion styles. Examples are provided, bringing the study of this country closer to the studies of material culture in Eastern Europe, region with which comparisons are made. Keywords: material culture, fashion, denotative understandings, socialism, Cuba
Buscar en la ausencia. ‘Lo soviético’ en los cuentos y las identidades cubanas
Authors: Heinrich Carola 
Published: September 2015

RESUMEN Durante más de tres décadas, la Unión Soviética penetró en todas las esferas de la vida cubana. A pesar de ese largo período de intercambio, lo soviético no aparecía en la producción literaria más que en contadas ocasiones. Sólo después de la caída del campo socialista despierta la memoria de aquella compleja etapa histórica. El análisis trata las huellas que dejaron la Unión Soviética y su derrumbe en la sociedad cubana y en la identidad de sus miembros por medio de su manifestación en los cuentos contemporáneos escritos a partir de los años noventa. La representación de ‘lo soviético’ y de ‘lo cubano’, de ‘lo ajeno’ y de ‘lo propio’ se examina con respecto al contenido y a una particular estilística y estrategia literaria. A efectos de la teoría poscolonial, se interpreta el significado que sigue teniendo la Unión Soviética para los constructos identitarios. ABSTRACT The collapse of the Soviet Union evoked a social, economic, ideological and cultural upheaval in Cuba. It not only caused an economic crisis, but particularly led to the deprivation of certainty and utopianism. This instability is also expressed in literature. The paper will study Cuban short stories written after 1989. The object of investigation is the depiction of ‘the Russian’ as a representative of the Soviet Union and as a contrast to the population of the own. The opposition between ‘the own’ and ‘the other’ will be analyzed regarding content and particularly literary style and strategy. The alternating power dynamic and its corresponding literary expression are analyzed, and a resulting contemporary identity concept will be deduced, applying the postcolonial theory. The impact of the Soviet Union on identity construction as the former hegemonic power and its expression in contemporary short stories will be analyzed and interpreted.
Cuba socialista. De la traducción y sus secuelas
Authors: Puñales-Alpízar Damaris 
Published: September 2015

Resumen: Este ensayo propone un acercamiento a la literatura socialista en español que era consumida en Cuba en las décadas del sesenta al noventa y, siguiendo las teorías de la traducción de Itamar Evan-Zohar, intenta dilucidar el papel periférico y central que esa literatura tuvo en la conformación del polisistema literario cubano. ¿Hasta qué punto esa literatura tuvo una función utilitaria para impulsar una ideología de estado? ¿Cómo se relaciona la llegada de la literatura socialista a la isla con una tradición de la traducción en Cuba que ha sido fundamental en la creación de una noción de la nación desde las letras? Estas son las interrogantes principales que guían estas notas que no intentan ser conclusión, sino punto de partida para un debate sobre una identidad cubana siempre en transición. Abstract: This paper proposes an approach to the socialist literature in Spanish that was consumed in Cuba from the sixties to the nineties and, following the theories of translation of Itamar Evan-Zohar, attempts to elucidate the peripheral and central role that such literature had on the conformation of a Cuban literary polysystem. To what extent this literature had a utilitarian function to promote an ideology of state? How the arrival to the island of socialist literature relates to a tradition of translation in Cuba which has been instrumental in creating a notion of the nation within the Republic of the letters? These are the main questions that guide these notes –not intended as a conclusion, but a starting point for a debate on a Cuban identity that is always in transition.
El futuro pertenece por entero al Comunismo! Influencias del cine de ciencia ficción de la URSS y de otros países del Este en el imaginario literario cubano
Authors: Aguiar Raúl 
Published: September 2015

Resumen: La ciencia ficción cubana, particularmente en los años 80 del siglo XX, resulta bastante diferente de la realizada en otros países de Latinoamérica. Este artículo trata de desentrañar la influencia que pudo tener en la configuración de tal especificidad el cine fantástico soviético estrenado en Cuba de manera regular desde 1961 hasta la desaparición de la URSS. El texto, por un lado, reconstruye cronológicamente la presencia del cine fantástico soviético en la isla. Por otro, aborda con detalle la influencia directa de tales películas en el imaginario fantástico de la literatura cubana. Lo hace a través de algunas obras esenciales del fantástico soviético como El hombre anfibio (Tchabotae y Kazanski, 1961), El planeta de las tormentas (Klushantsev, 1962), La nebulosa de Andrómeda (Sherstobitov, 1967), Solaris (Tarkovski, 1971) y El silencio del doctor Ivens (Metalnikov, 1973) y de la literatura cubana, como Transparencia (Ángel Arango, 1982), Espiral (Agustín de Rojas, 1980) y Beatriz (Félix Lizarraga, 1981).Abstract: Cuban science-fiction, especially in the 80’s, is quite different from the science-fiction written in other Latin countries. This paper tries to unravel the influence that fantastic Soviet films, which were regularly premiered in Cuba since 1961 until the demise of the USSR, could have had in shaping such specificity in Cuban literature. The text, firstly, reconstructs chronologically the presence of fantastic Soviet cinema in the island. Secondly, it addresses in detail the direct influence of such movies in fantastic Cuban literature. It does so through some essential works of Soviet fantastic.
Caviar con Ron: 'Sdelano na Kube'
Authors: Loss Jacqueline , Prieto José Manuel 
Published: September 2015

En Caviar con Ron: 'Sdelano na Kube', Jacqueline Loss y José Manuel Prieto analizan la gama vasta de actitudes hacia lo soviético -desde una minimización del impacto soviético en Cuba a una expresión exagerada de gratitud hacia los “rusos”- que se han encontrado desde que comenzaron su colaboración investigativa en 2004. Notan que las transformaciones en la memorialización, de una negación rotunda a una aceptación actual que no dudarían de llamar entusiasta, fueron algo que no pudieron anticipar del todo cuando decidieron organizar el que puede considerarse el primer simposio internacional (2007) dedicado a estudiar el impacto del vínculo soviético en Cuba y publicar el libro Caviar with Rum: Cuba-USSR and the Post-Soviet Experience (2012), que aquilató las huellas de esa, extraña relación de un país del “tercer mundo” con una potencia lejana y virtualmente desconocida, todo dentro del marco de la Guerra Fría. En este texto, buscan compartir su experiencia, relatar sus principales etapas y el estado actual de la cuestión del imaginario cubano de lo soviético y lo ruso. In “Caviar with Rum: Sdelano na Kube,” Jacqueline Loss and José Manuel Prieto analyze the vast range of attitudes toward the Soviet -from the minimization of the Soviet impact in Cuba to an exaggerated expression of gratitude toward the “Russians”- that they have encountered since they began their investigative collaboration in 2004. They note that the transformations in the memorialization, from an emphatic negation to an acceptance these days that they might even call enthusiastic, were something that they could not anticipate in the least when they decided to organize what can be considered as the first international symposium (2007) dedicated to studying the impact of the Soviet link in Cuba, and the publication of the book Caviar with Rum: Cuba-USSR and the Post-Soviet Experience (2012) that assessed the remnants of this strange relationship between a “Third Word” country with a far-away and virtually unknown power, all within the framework of the Cold War. In this text, they seek to share their experience, telling the first stages and the current state of the question of the Cuban imaginary of the Soviet and the Russian.
Sputniks cubanos. De cómo la URSS ocupó la imaginación de una generación
Authors: Toledano Redondo Juan Carlos 
Published: September 2015

Resumen: A pesar de la cierta marginalidad de la ciencia ficción en Cuba, ésta no estuvo exenta de la influencia cultural que sufrió la isla al sovietizarse. De la URSS y el entorno comunista llegaron cientos de obras del género, al mismo tiempo que la producción local se reducía a cero en los años setenta. Los autores cubanos tomaron partido, unos defendieron los nuevos estilos e ideas venidos del Este; otros decidieron seguir su camino, algunas veces, a contracorriente. Abstract: Despite the somewhat marginalization of science fiction in Cuba, the genre could not avoid the cultural influence that the island experienced when it adopted Soviet cannons. From the USSR and the Communist allies came hundreds of genre publications in the seventies, while local production was reduced to zero. Most Cuban writers took sides, some defended the new styles and ideas that came from the East; others decided not to, and even created sometimes a counter discourse.
Kinofikatsia cubana y sus fantasmas. Inventario de la presencia (y de la ausencia) del cine soviético en las pantallas de Cuba (1961-1991)
Authors: Muguiro Altuna Carlos 
Published: September 2015

Resumen: Entre 1961 y 1991, aproximadamente 800 largometrajes soviéticos fueron estrenados en los cines comerciales de Cuba, lo que significa que en la isla se distribuyó buena parte de la producción cinematográfica de la URSS de ese periodo. A su vez, la Cinemateca de Cuba organizó en ese tiempo más de 2.000 sesiones diferentes dedicadas al cine soviético, lo que le permitió reunir en sus fondos, poco a poco, la mayor colección de cine soviético del hemisferio occidental. A partir de mis recientes investigaciones en los archivos cubanos, este artículo proporciona datos desconocidos y estadísticas que concretan lo que significó realmente aquel proceso de ocupación cultural. Además, el texto enumera algunos conceptos de análisis de carácter estético e histórico y se interroga sobre si aquel proceso podría integrarse en la llamada, kinofikatsia soviética, el gran proyecto de expansión cinematográfica desarrollada en la URSS desde los años 20. Palabras clave: Kinofikatsia, Cuba, URSSAbstract: Between 1961 and 1991, approximately 800 different Soviet feature films were screened in commercial cinemas in Cuba, meaning that a significant number of the films made in the USSR in the period were shown in the island. The Cinemateca de Cuba also organized more than 2,000 different sessions on Soviet film and the archives of the ICAIC (Cuban Institute of Cinematographic Art and Industry) gradually amassing all this material, came to form the most important Soviet film collection in the western hemisphere. Based on my recent research at the Cuban archives, this article provides unknown data and statistics of this process of cultural occupation. In addition, its addresses some aesthetical and historical elements of analysis and wonders if that process could be seen as part of the, so called, soviet kinofikatsia, the huge project of film expansion developed by the USSR. Key words: Kinofikatsia, Cuba, USSR
Andróginos y ciborgs: monstruos de deconstrucción
Authors: Sánchez Anguix Ana 
Published: September 2015

Resumen En nuestro corpus, conformado por obras literarias y cinematográficas, los cuerpos monstruosos del ciborg y del andrógino devienen seres fronterizos que cuestionan los parámetros de sexo, género y deseo. Lo humano es puesto en duda y lo invisible se vuelve visible, abriendo un amplio espectro en la naturaleza. En el presente estudio se examinan las figuras del andrógino y del ciborg a la luz de las teorías de género: por un lado, se estudia el lugar de ambos monstruos en el feminismo deconstructivista; por otro, desde la perspectiva queer, ambos puntos de vista vinculados. Para nuestro análisis se tendrán en cuenta conceptos como género/sexo, dualidad sexual, intersexualidad o (hetero)patriarcado. Palabras clave: androginia, ciborg, género, feminismo, queer. Abstract In the works here analyzed –literary as well as filmic discourses- cyborg and androgyne monstrous bodies become frontier beings which question sex, gender and desire patterns. What is human is also questioned, and the invisible turns into visible, thus widening our notion of the natural. In the present study, androgyne and cyborg are examined from a gender perspective: on the one hand, these monsters are taken into account from feminist deconstruction view; on the other hand, we will go back to our works analyzing them from the queer theory perspective. Both feminism and queer theory are, though, related to each other. Throughout our whole study, we will consider terms such as gender/sex, sexual duality, intersex or (hetero)patriarchy. Key terms: androgyny, cyborg, gender, feminism, queer.
Ionospheric response to the 2015 St. Patrick's Day storm: A global multi‐instrumental overview
Authors: Astafyeva Elvira , Zakharenkova Irina , Förster Matthias 
Published: September 2015

AbstractWe present the first multi‐instrumental results on the ionospheric response to the geomagnetic storm of 17–18 March 2015 (the St. Patrick's Day storm) that was up to now the strongest in the 24th solar cycle (minimum SYM‐H value of −233 nT). The storm caused complex effects around the globe. The most dramatic positive ionospheric storm occurred at low latitudes in the morning (~100–150% enhancement) and postsunset (~80–100% enhancement) sectors. These significant vertical total electron content increases were observed in different local time sectors and at different universal time, but around the same area of the Eastern Pacific region, which indicates a regional impact of storm drivers. Our analysis revealed that this particular region was most concerned by the increase in the thermospheric O/N2 ratio. At midlatitudes, we observe inverse hemispheric asymmetries that occurred, despite the equinoctial period, in different longitudinal regions. In the European‐African sector, positive storm signatures were observed in the Northern Hemisphere (NH), whereas in the American sector, a large positive storm occurred in the Southern Hemisphere, while the NH experienced a negative storm. The observed asymmetries can be partly explained by the thermospheric composition changes and partly by the hemispherically different nondipolar portions of the geomagnetic field as well as by the IMF By component variations. At high latitudes, negative ionospheric storm effects were recorded in all longitudinal regions, especially the NH of the Asian sector was concerned. The negative storm phase developed globally on 18 March at the beginning of the recovery phase.