bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized, Phase II, Placebo-Controlled, Double-Blind Study With and Without Enzastaurin in Combination With Paclitaxel and Carboplatin As First-Line Treatment Followed by Maintenance Treatment in Advanced Ovarian Cancer
Authors: Vergote Ignace B. , Chekerov Radoslav , Amant Frederic , Harter Philipp , Casado Antonio , Emerich Janusz , Bauknecht Thomas , Mansouri Kambiz , Myrand Scott P. , Nguyen Tuan S. , Shi Peipei , Sehouli Jalid 
Published: July 2013

PurposeEnzastaurin is an oral serine/threonine kinase inhibitor antitumor agent. Our phase II trial tested the efficacy and safety of enzastaurin added to a standard carboplatin/paclitaxel chemotherapy regimen in patients with newly diagnosed advanced ovarian cancer.Patients and MethodsThis was a randomized, placebo-controlled study in patients with International Federation of Gynecology and Obstetrics stage IIB to IV ovarian, fallopian tube, or peritoneal epithelial carcinoma. Patients were randomly assigned to six cycles of chemotherapy (paclitaxel/carboplatin ± enzastaurin [PCE/PC]) followed by maintenance therapy (enzastaurin/placebo). Primary end point was progression-free survival (PFS). Secondary measures included response rate, safety assessment, and translational research.ResultsA total of 142 patients were randomly assigned to PCE (n = 69) or PC (n = 73). Patients in the PCE group had a 3.7-month longer median PFS compared with patients in the PC group; this was not statistically significant (hazard ratio [HR], 0.80; 95% CI, 0.50 to 1.29; P = .37). Safety profiles of the treatment arms were comparable. Frequency of discontinuation because of adverse events was similar (PCE, 11.9%; PC, 9.7%). Multivariate analyses confirmed the importance of optimal debulking with regard to PFS (debulking optimal v suboptimal: HR, 0.51; 95% CI, 0.30 to 0.85; P = .009). HR for covariate stage (stage IIB to IIIB v IIIC to IV) was not statistically significant (0.75; 95% CI, 0.38 to 1.47; P = .40). Translational research of immunohistochemistry protein assays did not identify any markers significantly associated with treatment difference regarding PFS.ConclusionThe PCE combination increased PFS, but it was not significantly superior to PC in this phase II study.
Hematopoietic Cell Transplantation for Systemic Mature T-Cell Non-Hodgkin Lymphoma
Authors: Smith Sonali M. , Burns Linda J. , van Besien Koen , LeRademacher Jennifer , He Wensheng , Fenske Timothy S. , Suzuki Ritsuro , Hsu Jack W. , Schouten Harry C. , Hale Gregory A. , Holmberg Leona A. , Sureda Anna , Freytes Cesar O. , Maziarz Richard Thomas , Inwards David J. , Gale Robert Peter , Gross Thomas G. , Cairo Mitchell S. , Costa Luciano J. , Lazarus Hillard M. , Wiernik Peter H. , Maharaj Dipnarine , Laport Ginna G. , Montoto Silvia , Hari Parameswaran N. 
Published: July 2013

Purpose To analyze outcomes of hematopoietic cell transplantation (HCT) in T-cell non-Hodgkin lymphoma. Patients and Methods Outcomes of 241 patients (112 anaplastic large-cell lymphoma, 102 peripheral T-cell lymphoma not otherwise specified, 27 angioimmunoblastic T-cell lymphoma) undergoing autologous HCT (autoHCT; n = 115; median age, 43 years) or allogeneic HCT (alloHCT; n = 126; median age, 38 years) were analyzed. Primary outcomes were nonrelapse mortality (NRM), relapse/progression, progression-free survival (PFS), and overall survival (OS). Patient, disease, and HCT-related variables were analyzed in multivariate Cox proportional hazard models to determine association with outcomes. Results AutoHCT recipients were more likely in first complete remission (CR1; 35% v 14%; P = .001) and with chemotherapy-sensitive disease (86% v 60%; P < .001), anaplastic large-cell histology (53% v 40%; P = .04), and two or fewer lines of prior therapy (65% v 44%; P < .001) compared with alloHCT recipients. Three-year PFS and OS of autoHCT recipients beyond CR1 were 42% and 53%, respectively. Among alloHCT recipients who received transplantations beyond CR1, 31% remained progression-free at 3 years, despite being more heavily pretreated and with more refractory disease. NRM was 3.5-fold higher (95% CI, 1.80 to 6.99; P < .001) for alloHCT. In multivariate analysis, chemotherapy sensitivity (hazard ratio [HR], 1.8; 95% CI, 1.16 to 2.87) and two or fewer lines of pretransplantation therapy (HR, 5.02; 95% CI, 2.15 to 11.72) were prognostic of survival. Conclusion These data describe the roles of autoHCT and alloHCT in T-cell non-Hodgkin lymphoma and suggest greater effectiveness earlier in the disease course, and limited utility in multiply relapsed disease. Notably, autoHCT at relapse may be a potential option for select patients, particularly those with anaplastic large-cell lymphoma histology.
Sorafenib in Combination With Intensive Chemotherapy in Elderly Patients With Acute Myeloid Leukemia: Results From a Randomized, Placebo-Controlled Trial
Authors: Serve Hubert , Krug Utz , Wagner Ruth , Sauerland M. Cristina , Heinecke Achim , Brunnberg Uta , Schaich Markus , Ottmann Oliver , Duyster Justus , Wandt Hannes , Fischer Thomas , Giagounidis Aristoteles , Neubauer Andreas , Reichle Albrecht , Aulitzky Walter , Noppeney Richard , Blau Igor , Kunzmann Volker , Stuhlmann Reingard , Krämer Alwin , Kreuzer Karl-Anton , Brandts Christian , Steffen Björn , Thiede Christian , Müller-Tidow Carsten , Ehninger Gerhard , Berdel Wolfgang E. 
Published: July 2013

Purpose The prognosis of elderly patients with acute myeloid leukemia (AML) is still dismal even with intensive chemotherapy. In this trial, we compared the antileukemic activity of standard induction and consolidation therapy with or without the addition of the kinase inhibitor sorafenib in elderly patients with AML. Patients and Methods All patients received standard cytarabine and daunorubicin induction (7+3 regimen) and up to two cycles of intermediate-dose cytarabine consolidation. Two hundred one patients were equally randomly assigned to receive either sorafenib or placebo between the chemotherapy cycles and subsequently for up to 1 year after the beginning of therapy. The primary objective was to test for an improvement in event-free survival (EFS). Overall survival (OS), complete remission (CR) rate, tolerability, and several predefined subgroup analyses were among the secondary objectives. Results Age, sex, CR and early death (ED) probability, and prognostic factors were balanced between both study arms. Treatment in the sorafenib arm did not result in significant improvement in EFS or OS. This was also true for subgroup analyses, including the subgroup positive for FLT3 internal tandem duplications. Results of induction therapy were worse in the sorafenib arm, with higher treatment-related mortality and lower CR rates. More adverse effects occurred during induction therapy in the sorafenib arm, and patients in this arm received less consolidation chemotherapy as a result of higher induction toxicity. Conclusion In conclusion, combination of standard induction and consolidation therapy with sorafenib in the schedule investigated in our trial is not beneficial for elderly patients with AML.
Prevalence and Co-Occurrence of Actionable Genomic Alterations in High-Grade Bladder Cancer
Authors: Iyer Gopa , Al-Ahmadie Hikmat , Schultz Nikolaus , Hanrahan Aphrothiti J. , Ostrovnaya Irina , Balar Arjun V. , Kim Philip H. , Lin Oscar , Weinhold Nils , Sander Chris , Zabor Emily C. , Janakiraman Manickam , Garcia-Grossman Ilana R. , Heguy Adriana , Viale Agnes , Bochner Bernard H. , Reuter Victor E. , Bajorin Dean F. , Milowsky Matthew I. , Taylor Barry S. , Solit David B. 
Published: July 2013

PurposeWe sought to define the prevalence and co-occurrence of actionable genomic alterations in patients with high-grade bladder cancer to serve as a platform for therapeutic drug discovery.Patients and MethodsAn integrative analysis of 97 high-grade bladder tumors was conducted to identify actionable drug targets, which are defined as genomic alterations that have been clinically validated in another cancer type (eg, BRAF mutation) or alterations for which a selective inhibitor of the target or pathway is under clinical investigation. DNA copy number alterations (CNAs) were defined by using array comparative genomic hybridization. Mutation profiling was performed by using both mass spectroscopy-based genotyping and Sanger sequencing.ResultsSixty-one percent of tumors harbored potentially actionable genomic alterations. A core pathway analysis of the integrated data set revealed a nonoverlapping pattern of mutations in the RTK-RAS-RAF and phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathways and regulators of G1-S cell cycle progression. Unsupervised clustering of CNAs defined two distinct classes of bladder tumors that differed in the degree of their CNA burden. Integration of mutation and copy number analyses revealed that mutations in TP53 and RB1 were significantly more common in tumors with a high CNA burden (P < .001 and P < .003, respectively).ConclusionHigh-grade bladder cancer possesses substantial genomic heterogeneity. The majority of tumors harbor potentially tractable genomic alterations that may predict for response to target-selective agents. Given the genomic diversity of bladder cancers, optimal development of target-specific agents will require pretreatment genomic characterization.
Comorbidity in adolescence: simultaneous
declaration of depressive, eating symptoms and use
of psychoactive substances in general population of
17 year old students in a big city.
Authors: Modrzejewska Renata 
Published: July 2013

Aim of the studyTo determine whether the following symptoms: depressive symptoms, eating disorder symptoms among adolescents in Cracow secondary schools are associated with an increased risk of psychoactive substance use.Subject or material and methodsA representative sample of the population of Krakow secondary school pupils was tested. A two-stage draw method identified a group of 2034 2nd form pupils of all types of secondary schools: grammar schools, technical schools and vocational schools (17-year olds). They were tested using the following screening questionnaires: Beck Depression Scale, EAT-26 eating disorders scale and author’s drug questionnaire.ResultsThe prevalence of depressive symptoms among boys and girls is associated with an increased alcohol use, cigarette smoking and drug use. All of the relationships are statistically significant in both sexes. 41.7% of depressive boys admit to smoking, versus. only 32.6% in the non-depressive group. The relationships are statistically significant in both sexes.
The prevalence of eating disorder symptoms among boys and girls is associated with a higher alcohol use, cigarette smoking, and drug use. Compared with a group of young people without eating disorder symptoms, the relationships are of statistical significance.DiscussionComorbidity of the following symptoms was found: depressive symptoms, eating disorder symptoms and symptoms of psychoactive substance use.ConclusionsThe presence of depressive symptoms increases the risk of the use of psychoactive substances, especially alcohol and tobacco, to a lesser extent – drugs, both in the boys and in the girls. The presence of eating disorder symptoms increases the risk of smoking and drug use among both boys and girls.
Climate change communications & young people in the Kingdom:
A reception study
Authors: Hibberd Matthew , Nguyen An 
Published: July 2013

Abstract
Based on focus groups with young people in England and Scotland and in-depth interviews with journalists, communication professionals and campaigners, this article examines how UK youths perceive climate change issues and how they receive climate messages from the news media and other communication forms. We found a strong sense of pessimism and disempowerment among our participants and identified a set of ‘triple-R reasons’ for their disengagement and inaction – namely the lack of relevance, resources and rituals. In that context, the media and other major communication forms have tended to hinder rather than help our young participants to be more actively involved and engaged – due mainly to the lack of positive and relevant messages and the focus on the extreme and the controversial.
The framing of climate change in Italian politics and its impact on public opinion
Authors: Blasio Emiliana De , Sorice Michele 
Published: July 2013

Abstract
The article examines the issue of climate change and its importance to Italian politics. In particular, the authors analyse whether political parties and their leaders give due importance to the issues in their party literature and speeches. In order to investigate this phenomenon, the authors studied manifestos of those political parties represented in Parliament between 2008 and 2013, other official documents available on their websites and official statements of political leaders. The overall picture emerging is a substantial lack of attention paid to climate change, which is also poorly represented in the Italian media. One of the key problems, however, lies in what we define as the ‘global’ dimension of the climate change debate that makes it look unattractive to local political discourse (where Italian politics is traditionally rooted). We argue this impacts negatively on public opinion and the lack of Italian public policies aimed at ensuring sustainability and promoting good behaviour and environmental best practice.
Thai audiences and journalists’ responses to a holistic, future-oriented, participatory and empowering (HOPE) model for climate change coverage
Authors: Salathong Jessada 
Published: July 2013

Abstract
Within the framework of the UN’s Decade for Education for Sustainable Development (2005–14), this article explores the potential of a Holistic, future-Oriented, Participatory and Empowering (HOPE) model for framing climate change in the media. A small-scale content analysis of three leading Thai dailies shows that most climate change stories have some, but not all, elements of HOPE. Follow-up in-depth interviews with Thai journalists and climate experts suggest that this is due to issues related to the practicality of implementing HOPE, especially day-to-day constraints on newswork – such as editors’ attitudes, editorial policies, newsroom resources. Finally, a focus group with Thai students finds that while audience members appreciate articles with all four HOPE elements, they think that a climate change story does not need to entail all elements to attract them, in part because it is not only the content but also its reporting style and form that make a story appealing. All in all, there is a general agreement that HOPE could serve as an ideal set of criteria for journalists to use as a guideline in framing climate change stories.
Actualizing a Spectator Like You: The Ethics of the Intrusive-Hypothetical
Authors: Frieze James 
Published: July 2013

Abstract
A stream of performance pieces over the last five years – including The Author (Tim Crouch), Tough time nice time (Ridiculusmus), Beachy Head (Analogue) and Make Better Please (Uninvited Guests) – have addressed the ethics of dramatic narrative via narratives that are presented as possible rather than actual. Mooted, proposed, quoted, imagined, these real yet hypothetical narratives court and assault their audience. Mocking our wish to make a difference while offering no genuine invitation to do so, these works script our failure to intervene. Drawing on Ganaele Langlois’s discussion of online participatory media platforms, and on Zygmunt Bauman’s ethical-existential view of ‘the liquid, modern world’ of digital, cognitive capitalism, I read these works as a distinct mode that I call intrusive-hypothetical performance. It is a mode that poses important ethical questions about the reification of the self in a digital-capitalist economy in which personality must, above all, be readable.
Crystal structure of poly[triaqua-µ2-sulfato-κ4O,O':O'',O'''-pyridine-3,5-dicarboxylato-κ4O,O':O'':O''']cerium(III) monohydrate, C7H11CeNO10S
Authors: Zhao Yan , Guo Dai Jian , Su Bei Ya , Xie Shi-Yu 
Published: July 2013

Abstract C7H11CeNO10S, monoclinic, C2/c (no. 15), a = 26.211(4) Å, b = 13.530(2) Å, c = 6.7481(9) Å, β = 92.294(1)°, V = 2391.1 Å3, Z = 8, Rgt(F) = 0.0179, wRref(F2) = 0.0472, T = 296 K.
Crystal structure of bis(isothiocyanato-κN)bis(4,4',5,5'-tetrahydro-2,2'-bithiazole-κ2N,N')cobalt(II), C14H16CoN6S6
Authors: Sun Jianhua , Liu Yuhai , Li Weihua , Chen Xuhong 
Published: July 2013

Abstract C14H16CoN6S6, triclinic, P1̅ (no. 2), a = 8.459(1) Å, b = 11.246(2) Å, c = 12.459(2) Å, α = 94.545(2)°, β = 92.845(2)°, γ = 107.001(2)°, V = 1126.6 Å3, Z = 2, Rgt(F) = 0.0418, wRref(F2) = 0.1095, T = 293 K.
Nonfatal Choking on Food Among Children 14 Years or Younger in the United States, 2001–2009
Authors: Chapin Meyli M. , Rochette Lynne M. , Annest Joseph L. , Haileyesus Tadesse , Conner Kristen A. , Smith Gary A. 
Published: July 2013

OBJECTIVE:
The objective of this study was to investigate the epidemiology of nonfatal choking on food among US children.

METHODS:
Using a nationally representative sample, nonfatal pediatric choking-related emergency department (ED) visits involving food for 2001 through 2009 were analyzed by using data from the National Electronic Injury Surveillance System–All Injury Program. Narratives abstracted from the medical record were reviewed to identify choking cases and the types of food involved.

RESULTS:
An estimated 111 914 (95% confidence interval: 83 975–139 854) children ages 0 to 14 years were treated in US hospital EDs from 2001 through 2009 for nonfatal food-related choking, yielding an average of 12 435 children annually and a rate of 20.4 (95% confidence interval: 15.4–25.3) visits per 100 000 population. The mean age of children treated for nonfatal food-related choking was 4.5 years. Children aged ≤1 year accounted for 37.8% of cases, and male children accounted for more than one-half (55.4%) of cases. Of all food types, hard candy was most frequently (15.5% [16 168 cases]) associated with choking, followed by other candy (12.8% [13 324]), meat (12.2% [12 671]), and bone (12.0% [12 496]). Most patients (87.3% [97 509]) were treated and released, but 10.0% (11 218) were hospitalized, and 2.6% (2911) left against medical advice.

CONCLUSIONS:
This is the first nationally representative study to focus solely on nonfatal pediatric food-related choking treated in US EDs over a multiyear period. Improved surveillance, food labeling and redesign, and public education are strategies that can help reduce pediatric choking on food.
A Randomized Trial of Nasal Prong or Face Mask for Respiratory Support for Preterm Newborns
Authors: McCarthy Lisa K. , Twomey Anne R. , Molloy Eleanor J. , Murphy John F.A. , O’Donnell Colm P.F. 
Published: July 2013

BACKGROUND AND OBJECTIVE:
Resuscitation guidelines recommend that respiratory support should be given to newborns via a face mask (FM) in the delivery room (DR). Respiratory support given to preterm newborns via a single nasal prong (SNP; ie, short nasal tube, nasopharyngeal tube) may be more effective. We wished to determine whether giving respiratory support to preterm newborns with a SNP rather than a FM reduces the rate of intubation in the DR.

METHODS:
Infants &lt;31 weeks’ gestation were randomized just before delivery to SNP (endotracheal tube shortened to 5 cm) or FM. Randomization was stratified by gestation (&lt;28 weeks, 28–30+6). Infants with apnea, respiratory distress, and/or heart rate &lt;100 received positive pressure ventilation with a T-piece. The primary outcome was intubation and mechanical ventilation in the DR. Infants in both groups were intubated for heart rate &lt;100 and/or apnea despite PPV and not solely for surfactant administration. All other aspects of treatment in the DR and NICU were the same. Relevant secondary outcomes were recorded and data were analyzed by using the intention-to-treat principle.

RESULTS:
One hundred forty-four infants were enrolled. The rate of intubation in the DR was the same in both groups (11/72 [15%] vs 11/72 [15%], P = 1.000]. Infants assigned to SNP had lower SpO2 at 5 minutes and received a higher maximum concentration of oxygen in the DR. There were no significant differences in other secondary outcomes.

CONCLUSIONS:
Giving respiratory support to newborn infants &lt;31 weeks’ gestation via a SNP, compared with a FM, did not result in less intubation and ventilation in the DR.
Diaper Need and Its Impact on Child Health
Authors: Smith Megan V. , Kruse Anna , Weir Alison , Goldblum Joanne 
Published: July 2013

BACKGROUND:
This is the first peer-reviewed study to quantify diaper need, propose a method to measure diaper need, and explore psychosocial variables associated with diaper need in a large sample of urban, low-income families.

METHODS:
Data were derived from a cross-sectional study in 877 pregnant and parenting women. Mothers completed surveys on topics related to mental health, basic needs, and health care use. Logistic regression was used to estimate the relationship between diaper need and psychosocial correlates.

RESULTS:
Almost 30% of mothers reported diaper need. Hispanic women were significantly more likely to report diaper need than African American women (odds ratio [OR]: 1.96; 95% confidence interval [CI]: 1.51–3.33), and women ≥45 years of age were significantly more likely than women between the ages of 20 and 44 years to report diaper need (OR: 2.53; 95% CI: 1.21–5.28). Women who reported mental health need were significantly more likely than women who did not report mental health need to report diaper need (OR: 1.89; 95% CI: 1.16–3.09).

CONCLUSIONS:
Although a majority of studies have examined family socioeconomic status as income and educational and employment status, emerging research suggests that indicators of material hardship are increasingly important to child health. This study supports this premise with the suggestion that an adequate supply of diapers may prove a tangible way of reducing parenting stress, a critical factor influencing child health and development. There is potential for pediatric providers to inquire about diaper need and refer families to a local diaper distribution service as 1 method to reduce parenting stress.