bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying spatial dependencies, trade‐offs and uncertainty in bioenergy costs: An Australian case study (1) – least cost production scale
Authors: Brinsmead Thomas S. , Herr Alexander , O'Connell Deborah A. 
Published: January 2015

AbstractThis paper analyzes costs of several biofuel production pathways in Australia from crop residues (stubble), a lignocellulosic feedstock. As well as land (and sea) transport suitable biofuels, we also consider electricity, and aviation biofuels. Some biofuel cost calculations assume a minimum processing plant scale, often based on contemporary fossil fuels production scales. The more theoretical approach here minimizes production cost by trading off processing and transport costs. Optimal scales and process component costs depend on feedstock spatial concentration; however total costs are less strongly dependent. Lower concentrations correspond to smaller processing plant and greater collection areas and costs. Processing costs are added to feedstock production and transport costs to derive biofuel supply cost ranges as a function of feedstock concentration in an Australian context. Sensitivity analysis then identifies significant parameters and confidence interval estimates. A companion paper generates Australian nationally aggregated supply cost curves. © 2014 Society of Chemical Industry and John Wiley & Sons, Ltd
Psychological Distress and Problem Drinking
Authors: Mentzakis Emmanouil , Roberts Bayard , Suhrcke Marc , McKee Martin 
Published: January 2015

AbstractWe examine the influence of harmful alcohol use on mental health using a flexible two‐step instrumental variables approach and household survey data from nine countries of the former Soviet Union. Using alcohol advertisements to instrument for alcohol, we show that problem drinking has a large detrimental effect on psychological distress, with problem drinkers exhibiting a 42% increase in the number of mental health problems reported and a 15% higher chance of reporting very poor mental health. Ignoring endogeneity leads to an underestimation of the damaging effect of excessive drinking. Findings suggest that more effective alcohol polices and treatment services in the former Soviet Union may have added benefits in terms of reducing poor mental health. Copyright © 2015 John Wiley & Sons, Ltd.
Synthesis of novel polyesters for potential applications in skin tissue engineering
Authors: Kanitkar Akanksha , Smoak Mollie , Chen Cong , Aita Giovanna , Scherr Thomas , Madsen Lee , Hayes Daniel 
Published: January 2015

AbstractBACKGROUNDIn this study, polyesters of glycerol, aconitic acid and cinnamic acid were synthesized and studied for their potential application as scaffolds in tissue engineering. Aconitic acid can be recovered from molasses, while glycerol and cinnamic acid can be recovered from pretreated sugarcane bagasse used for bio‐ethanol production. Polyester synthesis was carried out at different molar ratios of reactants at a temperature of 120 °C for 5 h. Synthesized polyesters were characterized chemically and mechanically, and evaluated for their cytotoxicity and chemical stability towards human adipose derived mesenchymal pluripotent stem cells (hASC).RESULTSSeveral cytocompatibility tests such as mass loss over a period of time, alamar blue to analyze growth and viability ofhASCon polyester scaffolds, picogreen for totalDNAcontent synthesized, indicated that these polyesters hold promise as tissue engineering scaffolds. For skin tissue engineering, especially for wound repair, thin film polyester scaffolds laden withhASCwere grown in stromal medium supplemented with basic fibroblast growth factor (bFGF). For all the scaffolds, the amount of collagen synthesized inbFGFsupplemented medium was significantly higher than the scaffolds withhASCin control (stromal) medium (P<0.05)CONCLUSIONBased on the amount of collagen synthesized andDNAquantification data, it was concluded that the polyesters are cytocompatible and support fibroblastic differentiation by the addition ofbFGF. © 2015 Society of Chemical Industry
A scalable seamless full color PMOLED
Authors: Yan Xiaojian , Tian Chaoyong , Jiang Wei , Xia Weigao , Wei Xinying 
Published: January 2015

AbstractPassive matrix organic light emitting display is restricted to its passive driving method, so it is hard to make the screen size and resolution larger because the brightness is reduced with the row numbers and it needs a driver Integrated Circuit (IC) with high current supply. In order to make high resolution and large size Organic Light Emitting Display (OLED), companies invest much money to produce Active Matrix Organic Light Emitting Display (AMOLED). But compared with AMOLED, Passive Matrix Organic Light Emitting Display (PMOLED) has simple fabrication process, which does not need very complex Thin Film Transistor (TFT) backplane and also has less material cost.In this paper, we research the ordinary design of PMOLED panel, and finally, we found a novel design to diminish the dead space of PMOLED on the left and right sides. With that, we can stitch pairs of PMOLED unit together to make the PMOLED panel larger and have higher resolution. We also developed the manufacture process for this new type of PMOLED panel.Using our novel method, we finally made a 3.5 inch PMOLED panel with a resolution of 160 (RGB) × 240 and developed the driving method for this sample using two commercialized PMOLED driver chip and Microprogrammed Control Unit (MCU) chip. So with the novel method, we can make many PMOLED panel stitched together to make larger PMOLED with higher resolution.
Current trends in surgical approach and outcomes following pituitary tumor resection
Authors: Villwock Jennifer A. , Villwock Mark R. , Goyal Parul , Deshaies Eric M. 
Published: January 2015

Objectives/HypothesisThe goals of pituitary tumor resection include normalizing endocrine function, relieving mass effect, and minimizing risk of recurrence. This study investigated current trends in costs and complications for transfrontal and transsphenoidal pituitary surgery.Study DesignRetrospective review of the 2008–2011 Nationwide Inpatient Sample for patients undergoing pituitary lesion resection.MethodsDemographics and outcomes were compared between transfrontal and transsphenoidal surgical approaches using χ2 tests. Multivariate analysis was performed to investigate outcomes while controlling for confounders.ResultsThere were 8,543 admissions for resection of pituitary lesions that met our inclusion criteria. Most (>90%) were treated transsphenoidally. The transfrontal approach was most frequent in the young (<35 years) and in the South. Rates of mortality and complications were higher in patients undergoing transfrontal surgery. Multivariate analysis found transsphenoidal resection was associated with a reduction in hospital costs and length of stay by over 50%; low‐volume hospitals had increased cost and length of stay. There was an increased rate of transfrontal approaches at low‐volume centers.ConclusionsMultiple factors influence outcomes of pituitary tumor resection. Transsphenoidal pituitary surgery is associated with a shorter length of stay, lower cost, and lower complication rates when compared to transfrontal surgery. Case specifics, including tumor location and size, influence approach and lead to a selection bias that cannot be controlled for in the present study. The prevalence of transfrontal resections at low‐volume centers may indicate an area of further investigation. Additionally, when controlling for surgical approach, low‐volume centers were found to adversely affect economic outcomes and also warrants investigation.Level of Evidence2c. Laryngoscope, 125:1307–1312, 2015
Inhibition of miR-15a Promotes BDNF Expression and Rescues Dendritic Maturation Deficits in MeCP2-Deficient Neurons
Authors: Gao Yu , Su Juan , Guo Weixiang , Polich Eric D. , Magyar Daniel P. , Xing Yina , Li Hongda , Smrt Richard D. , Chang Qiang , Zhao Xinyu 
Published: January 2015

Abstract
In both the embryonic and adult brain, a critical step in neurogenesis is neuronal maturation. Deficiency of MeCP2 leads to Rett syndrome, a severe neurodevelopmental disorder. We have previously shown that MeCP2 plays critical roles in the maturation step of new neurons during neurogenesis. MeCP2 is known to regulate the expression of brain-derived neurotrophic factor (BDNF), a potent neurotrophic factor for neuronal maturation. Nevertheless, how MeCP2 regulates BDNF expression and how MeCP2 deficiency leads to reduced BDNF expression remain unclear. Here, we show that MeCP2 regulates the expression of a microRNA, miR-15a. We find that miR-15a plays a significant role in the regulation of neuronal maturation. Overexpression of miR-15a inhibits dendritic morphogenesis in immature neurons. Conversely, a reduction in miR-15a has the opposite effect. We further show that miR-15a regulates expression levels of BDNF, and exogenous BDNF could partially rescue the neuronal maturation deficits resulting from miR-15a overexpression. Finally, inhibition of miR-15a could rescue neuronal maturation deficits in MeCP2-deficient adult-born new neurons. These results demonstrate a novel role for miR-15a in neuronal development and provide a missing link in the regulation of BDNF by MeCP2. Stem Cells 2015;33:1618–1629
Reversible Lineage-Specific Priming of Human Embryonic Stem Cells Can Be Exploited to Optimize the Yield of Differentiated Cells
Authors: Lee Jung Bok , Graham Monica , Collins Tony J. , Lee Jong-Hee , Hong Seok-Ho , Mcnicol Amie Jamie , Shapovalova Zoya , Bhatia Mickie 
Published: January 2015

Abstract
The clinical use of human embryonic stem cells (hESCs) requires efficient cellular expansion that must be paired with an ability to generate specialized progeny through differentiation. Self-renewal and differentiation are deemed inherent hallmarks of hESCs and a growing body of evidence suggests that initial culture conditions dictate these two aspects of hESC behavior. Here, we reveal that defined culture conditions using commercial mTeSR1 media augment the expansion of hESCs and enhance their capacity for neural differentiation at the expense of hematopoietic lineage competency without affecting pluripotency. This culture-induced modification was shown to be reversible, as culture in mouse embryonic fibroblast-conditioned media (MEF-CM) in subsequent passages allowed mTeSR1-expanded hESCs to re-establish hematopoietic differentiation potential. Optimal yield of hematopoietic cells can be achieved by expansion in mTeSR1 followed by a recovery period in MEF-CM. Furthermore, the lineage propensity to hematopoietic and neural cell types could be predicted via analysis of surrogate markers expressed by hESCs cultured in mTeSR1 versus MEF-CM, thereby circumventing laborious in vitro differentiation assays. Our study reveals that hESCs exist in a range of functional states and balance expansion with differentiation potential, which can be modulated by culture conditions in a predictive and quantitative manner. Stem Cells 2015;33:1142–1152
1∞[Pr(BSB)3(py)2]: A Lanthanide Bis(salicylato)borate at the Junction between Solvothermal and Ionothermal Conditions
Authors: Zottnick Sven H. , Sorg Jens R. , Sprenger Jan A. P. , Finze Maik , Müller‐Buschbaum Klaus 
Published: January 2015

AbstractA coordination polymer of the formula 1∞[Pr(BSB)3(py)2] constituted of bis(salicylato)borate anions ([BSB]–) and Pr3+ was synthesized as single crystals from the sodium salt under solvothermal conditions in pyridine. The formation of sodium chloride is a driving force valid for a reaction under solvothermal and ionothermal conditions using the ionic liquid (IL) 1‐ethyl‐3‐methylimidazolium‐bis(salicylato)borate [EMIM][BSB]. For the formation of isoconstitutional compounds the latter reaction also requires a certain amount of pyridine, which is beneficial for crystallization. In addition, a different precursor has to be employed: whilst the solvothermal reaction can be carried out with the anhydrous halide LnCl3, the IL‐based reaction is only successful with the complex [LnCl3(py)4] as precursor.
Integrative analysis of sequencing and array genotype data for discovering disease associations with rare mutations
Authors: Hu Yi-Juan , Li Yun , Auer Paul L. , Lin Dan-Yu 
Published: January 2015

Significance
High-throughput DNA sequencing provides an unprecedented opportunity to discover rare genetic variants associated with complex diseases and traits. However, sequencing a large number of subjects is prohibitively expensive. It is common to select subjects for sequencing from the cohorts that have collected genotyping array data. We impute the sequencing data from the array data for the cohort members who are not selected for sequencing and perform gene-level association tests for rare variants by properly combining the observed genotypes for sequenced subjects and the imputed genotypes for nonsequenced subjects. This integrative analysis is substantially more powerful than the use of sequencing data alone and can accelerate the search for disease-causing mutations.
Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells
Authors: Strüber Michael , Jonas Peter , Bartos Marlene 
Published: January 2015

Significance
The activity dynamics of cortical circuits are directly determined by the composing cells and their connections. Inhibitory interneurons are important regulators of neuronal network function. However, how the functional properties of their output synapses relate to the spatial dimension of the network is unknown. Here, we show that perisoma-inhibiting fast-spiking interneurons differentially inhibit close and distant principal cells: inhibitory strength declines and signal duration increases with distance between the presynaptic interneurons and the postsynaptic principal cell. This feature of cortical GABAergic inhibitory signaling supports the interneuron’s potential to synchronize large principal cell populations at gamma (>30 Hz) frequencies, a prerequisite for the encoding and storing of information in neuronal networks.
Recent shifts in the occurrence, cause, and magnitude of animal mass mortality events
Authors: Fey Samuel B. , Siepielski Adam M. , Nusslé Sébastien , Cervantes-Yoshida Kristina , Hwan Jason L. , Huber Eric R. , Fey Maxfield J. , Catenazzi Alessandro , Carlson Stephanie M. 
Published: January 2015

Significance
Mass mortality events (MMEs), the rapid, catastrophic die-off of organisms, are an example of a rare event affecting natural populations. Individual reports of MMEs clearly demonstrate their ecological and evolutionary importance, yet our understanding of the general features characterizing such events is limited. Here, we conducted the first, to our knowledge, quantitative analysis of MMEs across the animal kingdom, and as such, we were able to explore novel patterns, trends, and features associated with MMEs. Our analysis uncovered the surprising finding that there have been recent shifts in the magnitudes of MMEs and their associated causes. Our database allows the recommendation of improvements for data collection in ways that will enhance our understanding of how MMEs relate to ongoing perturbations to ecosystems.
SLC29A1 polymorphism and prediction of anaemia severity in patients with chronic hepatitis C receiving triple therapy with telaprevir
Authors: Milazzo Laura , Peri Anna Maria , Mazzali Cristina , Magni Carlo , Calvi Elisa , De Nicolò Amedeo , Clementi Emilio , Cheli Stefania , D'Avolio Antonio , Antinori Spinello , Falvella Felicia Stefania 
Published: January 2015

AbstractObjectivesThe equilibrative nucleoside transporter 1 (ENT1) is the main protein involved in ribavirin cellular uptake. Polymorphisms at the SLC29A1 gene, encoding ENT1, may influence ribavirin-associated anaemia, which is observed at a higher incidence with telaprevir in combination with pegylated-IFNα and ribavirin than with pegylated-IFNα and ribavirin alone. In this study, we investigated the role of the rs760370 SLC29A1 variant in ribavirin-induced anaemia in chronic hepatitis C patients treated with telaprevir-based triple therapy.MethodsForty patients infected with hepatitis C virus (HCV) genotype 1 and starting anti-HCV therapy with telaprevir in combination with pegylated-IFN/ribavirin were prospectively evaluated for SNPs at the SLC29A1 gene and inosine triphosphatase (ITPA) genes using a real-time PCR system.Results40% of patients developed severe anaemia with a haemoglobin (Hb) decline ≥5 g/dL from the pretreatment value. The SLC29A1 rs760370 GG genotype was associated with the severity of Hb decrease as expressed by the median (IQR) Hb nadir change from baseline [−5.4 (−5.6; −5.0) g/dL in GG versus −4.2 (−5.1; −3.4) in AA/AG genotype; P = 0.05] and by the Hb decrease ≥5 g/dL by week 12 (77.8% of GG carriers versus 24% of AA/AG; P &lt; 0.01). In multivariate analysis, older age (P = 0.03), lower baseline Hb concentration (P = 0.02) and SLC29A1 rs760370 GG (P = 0.02) were associated with the development of severe anaemia during treatment, whereas no association was found with ITPA SNPs in our population receiving telaprevir-based therapy.ConclusionsIn patients with chronic hepatitis C receiving telaprevir-based therapy, SNP rs760370A&gt;G at the SLC29A1 gene influences the severity of ribavirin-induced anaemia, possibly mirroring the erythrocyte uptake of ribavirin.
Tenofovir plasma concentrations related to estimated glomerular filtration rate changes in first-line regimens in African HIV-infected patients: ANRS 12115 DAYANA substudy
Authors: Lê Minh Patrick , Landman Roland , Koulla-Shiro Sinata , Charpentier Charlotte , Sow Papa-Salif , Diallo Mamadou-Baila , Ngom Gueye Ndèye Fatou , Ngolle Maguy , Le Moing Vincent , Eymard-Duvernay Sabrina , Benalycherif Aïda , Delaporte Eric , Girard Pierre-Marie , Peytavin Gilles ,   on behalf of the DAYANA Study Group, Landman R. , Peytavin G. , Charpentier C. , Koulla-Shiro S. , Ngolle M. , Kouanfack C. , Ymele B. , Elad O. , Sow P. S. , Diallo M. B. , Ouattara A. , Thiam A. , Ndiaye B. , Fall M. B. Koita , Essomba C. , Diop H. , Gueye F. Ngom , Sock A. , Legac S. , Simen E. , Maynart M. , Le Moing V. , Eymard-Duvernay S. , Kane C. Toure , Benalycherif A. , Aghokeng A. , Delaporte E. , Girard P. M. 
Published: January 2015

AbstractObjectivesAn open-label randomized trial (DAYANA) was conducted in sub-Saharan settings to evaluate four different regimens containing tenofovir disoproxil fumarate as first-line treatment for HIV infection. The objectives of the present substudy were to assess the relationship between trough concentrations of tenofovir in plasma collected after 24 h (C24) and estimated glomerular filtration rates (eGFR) calculated by the different formulae that are available.MethodsThe criteria for eligibility were those of the DAYANA trial, recruiting naive patients. The four tenofovir regimens were: Group 1, tenofovir/emtricitabine/nevirapine; Group 2, tenofovir/lopinavir/ritonavir; Group 3, tenofovir/emtricitabine/zidovudine; and Group 4, tenofovir/emtricitabine/efavirenz. The C24 of tenofovir was determined using LC-MS/MS. The eGFR was calculated using the Cockcroft–Gault, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulae.ResultsThe median C24 of tenofovir was 42 ng/mL. The C24 of tenofovir was higher with lopinavir/ritonavir than with the other three regimens: at Week 4, 84 ng/mL versus 25 ng/mL; and at Week 48, 81 ng/mL versus 52 ng/mL. The baseline merged eGFR was 98.2 mL/min/1.73 m2 with the CKD-EPI equation. Only the mean changes in eGFR in Group 2 differed from the absolute value of zero (−8.2 mL/min/1.73 m2) with the CKD-EPI equation between baseline and Week 48. The Cockcroft–Gault formula is inappropriate for these African patients because it underestimated the baseline eGFR and overestimated the changes in eGFR between baseline and Week 48.ConclusionsIn this population of mostly female HIV-1-infected African patients, tenofovir plasma overexposure was associated with PI/ritonavir and a time-dependent decrease in eGFR, probably via an inhibition of MRP2/MRP4 efflux transporters. The close monitoring over time of the eGFR using MDRD or CKD-EPI calculations and by using other biomarkers of renal disorder should be proposed as an alternative to therapeutic drug monitoring in resource-limited countries.
An exploration of the fruit and vegetable “foodscape” in a university setting for staff
Authors: Bevan Ann Lesley , Hartwell Heather , Hemingway Ann , Proença Rossana Pacheco da Costa 
Published: January 2015

Purpose
– The potential for the foodservice industry to be part of a public health strategy has led to a new understanding of this sector’s role in a wider interdisciplinary health environment. The purpose of this paper is to evaluate the influence of the foodscape on fruit and vegetable choice by staff in a higher educational setting.

Design/methodology/approach
– Foodscape mapping of fruit and vegetable provision on campus was conducted to provide context. Two focus groups with staff and two interviews with foodservice managers took place to gain depth of understanding. Thematic analysis was conducted to allow for pattern and meaning to emerge.

Findings
– Results demonstrate two main overarching themes; personal influence and food operator influence that impact on fruit and vegetable choice. In addition connectivity, perceptions of freshness, food quality and display seemed to be strong categories emerging from the data. Interestingly, this research indicated that consumers were more likely to eat fruit and vegetables when part of a composite dish than if served separately.

Practical implications
– Providing a positive foodscape to enhance availability of fruit and vegetables may be challenging but helpful towards health promotion. Nevertheless, no “nudging” can control choice made by individuals, responsibility for healthy selection must always remain personal.

Originality/value
– Knowledge gained by this pilot study will add to the body of literature and evidence base for further research while contributing to foodservice strategies which may promote increased fruit and vegetable consumption.