bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implicações da análise do conteúdo de ensino em seu aspecto lógico-histórico para a definição de ações didáticas
Authors: Sforni Marta Sueli de Faria , Belieri Cleder Mariano , Beleti Júnior Carlos Roberto 
Published: August 2024

Este ensaio visa apresentar como a análise do movimento lógico-histórico do conteúdo a ser ensinado instrumentaliza teoricamente o professor na definição das ações de ensino que visam o desenvolvimento do pensamento teórico dos estudantes. O manuscrito fundamenta-se na Lógica Dialética, na Teoria Histórico-Cultural e na Teoria do Ensino Desenvolvimental. Para a compreensão das implicações dessa análise na definição das ações de ensino, é apresentado, como exemplo, um exercício de análise do conteúdo mudanças de estado físico da água, do componente curricular Ciências da Natureza. A análise do movimento lógico-histórico permite identificar o que é nuclear para a compreensão do sistema conceitual objeto de ensino, bem como reconhecer os diversos objetos e fenômenos que podem ganhar inteligibilidade por meio da sua apropriação. Essa análise altera o modo de se conceber o conteúdo e a forma de ensino.
Asymptotic analysis of Leray solution for the incompressible NSE with damping
Authors: Blel Mongi , Benameur Jamel 
Published: August 2024

Abstract
In 2008, Cai and Jiu showed that the Cauchy problem of the Navier-Stokes equations, with damping

α

∣
u
∣

β
−
1

u

\alpha {| u| }^{\beta -1}u

for

α
>
0

\alpha \gt 0

and

β
≥
1

\beta \ge 1

has global weak solutions in

L

2

(

R

3

)

{L}^{2}\left({{\mathbb{R}}}^{3})

. In this article, we study the uniqueness and the continuity in

L

2

(

R

3

)

{L}^{2}\left({{\mathbb{R}}}^{3})

of this global weak solution. We also prove the large time decay for this global solution for

β
≥

10

3

\beta \ge \frac{10}{3}

.
Effect of a polyherbal Unani formulation on left ventricular diastolic dysfunction in hypertensive patients – a randomized single blind placebo controlled clinical trial
Authors: Khanum Asia , Khan Javed Ali , Shahid Arisha , Riyazuddin Mohd , Siddiqui Mansoor Ahmad 
Published: August 2024

Abstract

Objectives
Diastolic dysfunction represents an important pathophysiological intermediate between hypertension and heart failure. In the last two decades, the prevalence of heart failure patients having normal or near normal ejection fraction (EF) has increased to around 60 %. It thus poses a great morbidity and mortality risk to the population. In view of present scenario of high prevalence, lack of evidence-based therapy, and limited clinical trials, this study aimed to evaluate how a Unani formulation affects the improvement of the left ventricular diastolic function.

Methods
This clinical trial was set up as a randomized, placebo-controlled study involving 35 participants, with 18 individuals in the test group and 17 in the control group. Test group received 3.5 g of a polyherbal Unani formulation in capsule form along with 35 mL of an extract of Borago officinalis L. (Arq-e-Gaozaban), divided into two doses after meals. Meanwhile, the control group received a placebo in the same manner over an eight-week period. Follow-ups were conducted every 15 days to assess both subjective and objective parameters in all participants.

Results
The test formulation shows significant improvement in dyspnea and diastolic function from baseline to the end of trial (p<0.05), slight improvement in palpitations (p>0.05) and highly significant improvement in easy fatigability (p=0.001) as compared to the control.

Conclusions
The present study shows the effectiveness of the test drug in enhancing the diastolic function of left ventricle and alleviating other symptoms associated with ventricular diastolic dysfunction. Nevertheless, additional research with longer follow-up durations is necessary to clarify its efficacy and establish optimal treatment approaches for ventricular diastolic dysfunction in Unani medicine.
GNSS-IR soil moisture estimation using deep learning with Bayesian optimization for hyperparameter tuning
Authors: Daneghian Patricia , Rastbood Asghar 
Published: August 2024

Abstract
One of the ways for measuring water content is using global navigation satellite system (GNSS) multipath signals. By analyzing those signals, we will get useful information about the reflection surface. This technique is called GNSS interferometric reflectometry. Some receivers can record signal-to-noise ratio (SNR) data, which includes the SNR component of reflected signals and is strongly related to soil moisture. Here, we will use the data for station P038 in Mexico for 4 years, from 2017 until 2020. The calculation steps include extracting SNR data from RINEX files, estimating the prior reflector height and phase, calculating SNR metrics, and removing the vegetation effect to obtain volumetric water content (VWC). The results show that the VWC level has increased from 8.88 to 12.49% from 2017 to 2020. We have used long short-term memory neural networks with tuned hyperparameters by Bayesian optimization for predicting the time series of soil moisture. Our model is trained using 80% of the station observations. The accuracy of the network is checked using different metrics on the train, test, and all data. The mean absolute error, root mean square error, and a20-index of the test data are obtained as 0.002, 0.041, and 0.727, respectively. The modeling results will help farmers arrange their irrigation schedules more professionally.
Variable sampling time discrete sliding mode control for a flapping wing micro air vehicle using flapping frequency as the control input
Authors: Hill Joshua , Fahimi Farbod 
Published: August 2024

Abstract
In this article, two main assumptions commonly used in the reported literature are relaxed. First, instead of a continuous time controller, a discrete time controller is proposed. Second, the controller uses the flapping frequency as opposed to flapping force/moments as the control input commonly assumed by other research groups. A discrete time controller is more suitable for implementation and deployment to most real flapping wing micro aerial vehicles (FWMAVs), in which a computer controls a sampled system and the flapping wings are driven by servomotors. A robust reaching law based on the discrete sliding mode control method is proposed to stabilize the vertical altitude of a simulated FWMAV. The continuous time model of the FWMAV is converted to a discrete time model, and the discrete time sliding mode controller is developed for the new form of the model. Using the variable sampling time, the robust discrete sliding mode controller developed in this article is able to control a simulated FWMAV to successfully stabilize its position in spite of a 16% difference in model parameters, as well as a 0.7 m/s wind gust. The controller was able to withstand the wind gust with negligible deviation from its desired position. These simulation results further show an input frequency range similar to that of the experimentally derived model previously reported in the literature.
Reconstructions of the La Tène wagon wheels of Southeast Europe
Authors: Teleaga Emilian 
Published: August 2024

Summary
The examination in the relevant museums of the preserved metal parts of La Tène wagon graves of southeastern Europe enables, firstly, a precise determination of their function, and also the reconstruction of some wheels. The La Tène wheels were usually around 85 cm in diameter, hot iron tyres were pulled over the wooden felloes and fastened with a few additional nails (such as at Balsa or Toarcla). The wooden naves were reinforced with nave rings and pushed onto the axle-arm, the latter having a diameter of circa 5.5 cm. The axle nails prevented it from jumping off the axle-arm. In the case of the middle La Tène wagon wheels found at Curtuiușeni and the late La Tène chariot wheels found at Cugir, buffer rings with a band of circular fittings could be seen on the axle-arm between the axle nail and the nave head. In the case of Cugir the nave rings were made from cast bronze and the buffer ring claddings from wrought bronze.
Effluent wastewater technologies for textile industry: a review
Authors: Deshmukh Satyajit M. , Dhokpande Sonali R. , Sankhe Amaya , Khandekar Ajinkya 
Published: August 2024

Abstract
The textile industry contributes significantly to the expansion of the world economy, however, it is also notorious for producing large amounts of trash and harming the environment. Effective waste management techniques depend on having a thorough understanding of the forms and makeup of waste from the textile sector. The objective of this paper is to study effluent wastewater technologies to efficiently treat and control the wastewater produced during textile production operations. It is well known that the textile industry generates vast amounts of wastewater, some of which may be contaminated with heavy metals, chemicals, dyes, and organic compounds. This effluent can have serious negative effects on the environment if it is not adequately treated, including contaminating soil and water sources, removing aquatic life, and possibly endangering human health. Due to the inclusion of dyes, heavy metals, and other chemicals, the discharge of untreated or improperly treated effluent from textile processes leads to water contamination. Textile waste can leak hazardous compounds into the environment and contaminate the soil, both of which have an impact on air quality. The environmental impact of the textile industry is further exacerbated by the energy and resource use involved in production. At several points in the textile supply chain, waste is generated. Fibre trimmings, fly waste, and yarn waste are produced during the fibre production, spinning, and weaving operations. There are numerous ways and technologies for treating wastewater, including advanced oxidation processes (AOPs), biological treatment systems, and membrane-based technologies. The formation of eco-friendly materials and advancements in recycling technology help to make the textile industry more closed-loop and sustainable. In conclusion, managing waste from the textile sector is a significant environmental concern that calls for creative solutions and environmentally friendly procedures.
Ναζαρέτ and ναζωραῖος in the Gospel of John: The Johannine Jesus as a Nazirite?
Authors: Tops Thomas 
Published: August 2024

Abstract
The article examines the meaning of the words Ναζαρέτ and ναζωραῖος in the Fourth Gospel. It argues that the first word plays an important role in the incarnational logic of the Gospel, while the second word is significant for John’s Christology. Through the literary device of reader entrapment, John corrects the reader’s initial misjudgement that ὁ ναζωραῖος in John 18,5.7; 19,19 depicts Jesus as coming from Nazareth. To explain the Christological significance of this phrase, the article evaluates the thesis that ναζωραῖος characterises Jesus as a Nazirite. For instance, it compares the literary characterisation of the Johannine Jesus to the Nazirite rule in Num 6,1–21 and its reception in late Second Temple sources.
PROFESSIONAL MIDWIFERY EDUCATION IN BULGARIA AT THE TURN OF XX CENTURY: A HISTORICAL PERSPECTIVE
Authors: P. Gospodinova  , S. Dimitrova  
Published: August 2024

The goal of this article is to recount the birth and development of midwifery and maternal care education in Bulgaria after the Bulgarian Liberation at the end of XIX and the beginning of the XX century. The researchers set the following tasks: 1) to present the main reasons for the emergence of professional midwifery education in post-Liberation Bulgaria; 2) to show the place and role of the first professionally trained midwives in Bulgaria; 3) to outline the seminal work of notable personalities for the development of professional midwifery care.
Historical method was used, secondary historical sources, documents and scientific papers were reviewed.
Conclusions: Professional midwifery education helped the introduction and spread of modern Obstetrics/Gynecology medicine, which lead to decrease in maternal and infant mortality and slowly improved quality of life for Bulgarian women and children. Bulgarian nationals educated abroad brought to the country the scientific foundation and best practices in maternal health care.
Quistes ováricos en bovinos
Authors: Andrade J C 
Published: August 2024

Resumen Los ovarios quísticos son uno de los desórdenes reproductivos comunes en bovinos que afectan la fertilidad y contribuyen a extender el intervalo entre partos; ellos se clasifican como quistes foliculares, quistes lúteos y cuerpo lúteo quístico. Existe una amplia variedad de factores implicados en el desarrollo de esta alteración, dentro de los cuales podemos incluir genéticos, nutricionales y estacionales. La fisiopatología del desarrollo de los quistes no está completamente entendida, ya que se ven implicados una gran variedad de eventos; dentro de la hipótesis se mencionan: secreción basal elevada de LH durante el desarrollo folicular, reducción del número de receptores en la pared del folículo par LH y FSH, que es una condición heredable, infecciones uterinas, estrés y deficiencias nutricionales. Tradicionalmente el diagnóstico de la condición se hace por palpación transrectal y por historia reproductiva; también se utilizan análisis rápidos de la concentración de progesterona en sangre o leche como enzyme-linked-inmunoabsorbent assays (ELISA), radioimmunoassay (RIA) y latex agglutination (LA), además el advenimiento de la ultrasonografía es una gran ayuda. Dentro de la terapéutica se encuentra la ruptura manual y tratamientos hormonales, también se mencionan la acupuntura, homeopatía y suplementación selectiva de vitaminas, entre otras; hay que tener en cuenta también la recuperación espontanea para la evaluación de tratamientos. Summary The cystic ovaries are the most common reproductive disorders that affect fertility and delayed that farrowing interval. They are classified as follicular cysts, luteal cysts and corpus luteal cysts. There are a variety of involved factors in developing these disorders; within reasons, one can include genetical, nutritional and seasonal. The physiopathology mechanism of these disorders are not yet elucidated, due to their complex nature. Among the hypothesis are mentioned as causes, the basal elevated secretion of LH during the follicular development, decrease of LH-FSH receptor density on the follicular wall, heredity conditions, uterine infection, stress and nutritional deficiencies. Traditionally, the diagnosis tools commonly used are the trans-rectal palpation and reproductive records, but the screen blood and milk test are used also. There are ELISA, RIA, latex agglutination (LA), furthermore, the ultrasonic technique is a great tool. The widelay used therapies are hand rupture and hormonal interventions, alternatively, acupuncture, homeopathy, and selective supplementation of vitamins among other therapies are used. When evaluating treatments, the spontaneous resolution have to be in account.
Encuesta serológica de parvovirus en cerdos no vacunados y sacrificados en el matadero de Turbo
Authors: Molina L. S , Bermúdez L , Gil P 
Published: August 2024

Resumen Mediante la técnica de inhibición de la hemaglutinación se determinaron, los niveles de anticuerpos contra el Parvovirus porcino en 87 sueros de cerdos sacrificados en Turbo (Antioquia). Se obtuvo un porcentaje de reactores positivos del 49,42% (43/87). Los títulos de anticuerpos positivos entre machos y hembras fue del 65,9% (29/44) para los machos y 32,6% (14/43) para las hembras. Mediante la prueba estadística de independencia se halló alta relación entre las variables sexo y positividad, rechazando la hipótesis nula con un nivel de probabilidad del 5%. Summary In this study were determined the levels of antibodies to the porcine parvovirus in 87 animals sacrificed in Turbo (Antioquia). A percentage of positive and negative reactors of the 49.42% was obtained (43/87) respectively. The percentage of titles of positive antibodies were of 65.9% (29/44) for the male, and 32.6% (14/43) for the females. By means of the statistical test of independence was high relationship between the sex variable and positive, it refuse the null hypothesis with a level of probability of 5%
Formulasi Mie Substitusi Tepung Kelapa untuk Meningkatkan Kadar Serat
Authors: Nuraini Sekarsari , Wirjatmadi Bambang 
Published: August 2024

Latar Belakang: Penyakit tidak menular dapat dicegah dengan modifikasi diet, akan tetapi perubahan menu diet yang besar sulit dilakukan sebagian besar orang. Salah satu alternatif yang dapat dilakukan adalah dengan menambahkan zat gizi penting dalam bentuk menu diet yang familiar, seperti mie. Salah satu zat gizi yang dapat membantu adalah serat. Salah satu sumber serat di Indonesia adalah tepung kelapa yang diperoleh dari sisa pemerasan minyak kelapa dan santan.
Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh substitusi tepung kelapa terhadap daya terima mie dan kandungan serat mie substitusi.
Metode: Penelitian ini menggunakan desain faktorial dengan Rancangan Acak Lengkap. Penelitian dilakukan dengan 30 orang dewasa panelis tidak terlatih. Daya terima diukur dengan uji kesukaan pada 3 formula yang terdiri dari formula kontrol tanpa substitusi tepung kelapa (F0), formula substitusi dengan perbandingan tepung terigu dengan tepung kelapa 85%:15% (F1), formula dengan perbandingan tepung terigu dengan tepung kelapa 80%:20% (F2).
Hasil: Substitusi tepung terigu dengan tepung kelapa pada mie F1 dan F2 meningkatkan komposisi serat pada mie dari 1,99g/100g menjadi 5,98g/100g dan 7,31g/100g. Substitusi tidak berpengaruh signifikan terhadap paramater rasa dan aroma, akan tetapi berpengaruh pada penurunan tingkat kesukaan panelis pada parameter warna dan kekenyalan mie.
Kesimpulan: Kesimpulan yang didapat adalah substitusi tepung kelapa pada mie meningkatkan kadar serat pada formula mie yang disubsitusi dan menurunkan daya terima kekenyalan dan warna mie substitusi. Formula terbaik yang ditemukan adalah F1 dengan daya terima tertinggi diantara formula substitusi.
In Silico and In Vivo Studies of Carboxymethyl Cellulose Based Hydrogels from Cassava Stem and Young Papaya Seed Extract for Diabetic Wounds
Authors: Rahmawati Risma , Lestari Annisa Firda , Anggraini Putri Regita , Safitri Rahmadita Irma , A'yunin Alfi Rizki , Firdaus Maulidan 
Published: August 2024

ABSTRACT. Diabetic chronic wound care remains a global challenge due to higher rates of infection leading to amputations and death. The development of wound dressing materials with good biocompatibility, adequate mechanical strength, high absorption, and anti-inflammatory and antibacterial properties are criteria for ideal wound dressings in clinical applications. This study aimed to prepare hydrogel plasters based on carboxymethyl cellulose (CMC) from cassava stems (Manihot esculenta C.) with the addition of an active substance from young papaya seeds (Carica papaya L.) for diabetic wound healing. The methods used included CMC synthesis, extraction of young papaya seeds, preparation of nanoparticles, hydrogel optimization using Response Surface Methodology (RSM), in silico study, and in vivo tests. All products for each stage were characterized by FTIR and XRD. Hydrogels were characterized by testing pH, organoleptic, swelling ratio, gel fraction, biodegradability, FTIR, and SEM. The results of RSM optimization obtained hydrogel with the formula Na-CMC 3%, citric acid 2%, and stirring temperature 70. Based on the in-silico test results, the apigenin compound has the lowest binding energy, namely -9.4 kcal/mol, so it has the potential to heal diabetic wounds by triggering angiogenesis through the VEGFR2 signal. In vivo test results showed that the hydrogel with the addition of young papaya seed extract had the fastest wound healing rate compared to other treatments, marked by 100% wound closure on the 10th day.

Keywords: carboxymethyl cellulose, cassava stem, diabetes wound, hydrogel, young papaya seeds.
Antibacterial Test of The Essential Oil Fractions of Citronella (Cymbopogon nardus L.) Against Escherichia coli and Application as Hand Sanitizer Formulation
Authors: Rastuti Undri , Lestari Puji , Hidayatullah Rafly , Habibie Ranti Kamila 
Published: August 2024

ABSTRACT. Hand sanitizer is an essential item during the COVID-19 pandemic, posing potential side effects when containing synthetic ingredients. Therefore, this study aimed to replace hand sanitizer formulation with Citronella essential oil (Cymbopogon nardus L.). Essential oil was fractioned into 3 components, namely F1 (67.07% of limonene), F2 (92.39% of citronellal), and F3 (62.41% of geraniol) while evaluation was conducted on antibacterial properties against E. coli. Antibacterial test was performed using the well diffusion method, showing inhibition zone diameters of 7.40, 10.76, and 8.30 mm for F1 to F3 fractions, respectively. The results showed that F2, selected as the reference for hand sanitizer formulation, had the most potential antibacterial activity and a MIC of 3.125%. Comparative test with commercial alternatives, including hedonic, characteristic, and antibacterial activity test, were conducted to assess the formulated hand sanitizer. F2 was discovered to have an inhibition zone diameter of 29.56 mm as opposed to 9.06 mm of commercial hand sanitizer. Based on hendonic test, hand sanitizer formulated with citronella oil had a distinct smell, which was less preferred than lime fragrance.

Keywords: Antibacterial, Escherichia coli, and sanitizer, citronella essential oil.
Molecular Docking and Dynamic Simulation Studies of PHD2 Interactions with Gut Siderophores: Implications for HIF-1α Stabilization
Authors: Patel Jainabbi Irshad Ahamed , Kurdekar Namrata Manjunath , Padakannaya Apeksha , Javaregowda Palaksha Kanive , Khandagale Ajay Sathayanarayan , Joshi Chandrashekhar Gajana , Math Renukaradhya K , Majalakere Krishnakishore , Poyya Jagadeesha 
Published: August 2024

Abstract

In oxygen-deprived conditions cells respond by activating adaptive mechanisms to bolster their survival and protect tissue integrity. A key player in this process is the HIF-1α signaling cascade, meticulously regulated by Prolyl Hydroxylase Domain 2 (PHD2), which plays a central role in orchestrating cellular responses to fluctuating oxygen levels. The primary aim of this investigation is to explore potential PHD2 inhibitors using in-silico methods by employing molecular docking and dynamic simulation techniques. Low molecular-weight secondary metabolites known as Siderophores secreted from gut microbiota were selected and subjected for stringent assessment against PHD2. Molecular docking analysis revealed that Salmochelin SX (-9.527 Kcal/mol), Mycobactin (-9.166 Kcal/mol), Staphyloferrin A (-7.819 Kcal/mol), and Enterobactin (-7.302 Kcal/mol) displayed substantial affinities for the protein, suggesting them as potential inhibitors. Furthermore, Molecular Dynamic Simulation studies unveiled a noteworthy interaction between the metal ion, Fe2+, and the ligand molecules, indicating enhanced stability in these interactions. The iron-chelating property is a salient characteristic of many siderophores, and in the same lines our in-silico investigations have yielded promising results. However, it is essential to underscore that the validation of this study remains a critical step to substantiate our hypothesis. Further research and experimental investigations are necessary to confirm the practical implications of these findings and to assess the potential of the identified compounds as effective PHD2 inhibitors.