bluuebunny/crossref_metadata_2025_split huggingface dataset:
System Reliability of a Machine Repair System With a Multiple-Vacation and Unreliable Server
Authors: Chen Wu-Lin , Wen Chia-Hsien , Chen Zheng-Han 
Published: March 2015

AbstractThis study deals with reliability and sensitivity analysis of a machine repair system with warm standbys and an unreliable server having multiple-vacation. Failure times of operating and warm standby machines are assumed to be exponentially distributed with parameters λ and η, respectively. Vacation times of the server are also assumed to be exponentially distributed. A practical example of the model under consideration in this study is provided. The Laplace transform technique was used to derive the reliability function RY(t) and the mean time to system failure MTTF. We performed a parametric investigation that provided numerical results to show how various system parameters affect RY(t) and MTTF. Sensitivity analyses of RY(t) and MTTF, along with changes in specific values of the system parameters, were investigated. Relative sensitivity analyses of RY(t) and MTTF with various parameters were also studied.
Targeting DDX3 with a small molecule inhibitor for lung cancer therapy
Authors: Bol Guus M , Vesuna Farhad , Xie Min , Zeng Jing , Aziz Khaled , Gandhi Nishant , Levine Anne , Irving Ashley , Korz Dorian , Tantravedi Saritha , Heerma van Voss Marise R , Gabrielson Kathleen , Bordt Evan A , Polster Brian M , Cope Leslie , van der Groep Petra , Kondaskar Atul , Rudek Michelle A , Hosmane Ramachandra S , van der Wall Elsken , van Diest Paul J , Tran Phuoc T , Raman Venu 
Published: March 2015

AbstractLung cancer is the most common malignancy worldwide and is a focus for developing targeted therapies due to its refractory nature to current treatment. We identified a RNA helicase, DDX3, which is overexpressed in many cancer types including lung cancer and is associated with lower survival in lung cancer patients. We designed a first‐in‐class small molecule inhibitor, RK‐33, which binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK‐33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3‐overexpressing cells. Importantly, RK‐33 in combination with radiation induced tumor regression in multiple mouse models of lung cancer. Mechanistically, loss of DDX3 function either by shRNA or by RK‐33 impaired Wnt signaling through disruption of the DDX3–β‐catenin axis and inhibited non‐homologous end joining—the major DNA repair pathway in mammalian somatic cells. Overall, inhibition of DDX3 by RK‐33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy.
A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis
Authors: Palamiuc Lavinia , Schlagowski Anna , Ngo Shyuan T , Vernay Aurelia , Dirrig‐Grosch Sylvie , Henriques Alexandre , Boutillier Anne‐Laurence , Zoll Joffrey , Echaniz‐Laguna Andoni , Loeffler Jean‐Philippe , René Frédérique 
Published: March 2015

AbstractAmyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron disease in adults. Numerous studies indicate that ALS is a systemic disease that affects whole body physiology and metabolic homeostasis. Using a mouse model of the disease (SOD1G86R), we investigated muscle physiology and motor behavior with respect to muscle metabolic capacity. We found that at 65 days of age, an age described as asymptomatic, SOD1G86R mice presented with improved endurance capacity associated with an early inhibition in the capacity for glycolytic muscle to use glucose as a source of energy and a switch in fuel preference toward lipids. Indeed, in glycolytic muscles we showed progressive induction of pyruvate dehydrogenase kinase 4 expression. Phosphofructokinase 1 was inhibited, and the expression of lipid handling molecules was increased. This mechanism represents a chronic pathologic alteration in muscle metabolism that is exacerbated with disease progression. Further, inhibition of pyruvate dehydrogenase kinase 4 activity with dichloroacetate delayed symptom onset while improving mitochondrial dysfunction and ameliorating muscle denervation. In this study, we provide the first molecular basis for the particular sensitivity of glycolytic muscles to ALS pathology.
New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans
Authors: Kim Hyun-Min , Colaiácovo Monica P 
Published: March 2015

Abstract
Although a growing number of studies have reported the importance of SUMOylation in genome maintenance and DNA double-strand break repair (DSBR), relevant target proteins and how this modification regulates their functions are yet to be clarified. Here, we analyzed SUMOylation of ZTF-8, the homolog of mammalian RHINO, to test the functional significance of this protein modification in the DSBR and DNA damage response (DDR) pathways in the Caenorhabditis elegans germline. We found that ZTF-8 is a direct target for SUMOylation in vivo and that its modification is required for DNA damage checkpoint induced apoptosis and DSBR. Non-SUMOylatable mutants of ZTF-8 mimic the phenotypes observed in ztf-8 null mutants, including reduced fertility, impaired DNA damage repair, and defective DNA damage checkpoint activation. However, while mutants for components acting in the SUMOylation pathway fail to properly localize ZTF-8, its localization is not altered in the ZTF-8 non-SUMOylatable mutants. Taken together, these data show that direct SUMOylation of ZTF-8 is required for its function in DSBR as well as DDR but not its localization. ZTF-8’s human ortholog is enriched in the germline, but its meiotic role as well as its post-translational modification has never been explored. Therefore, our discovery may assist in understanding the regulatory mechanism of this protein in DSBR and DDR in the germline.
An Rtf2 Domain-Containing Protein Influences Pre-mRNA Splicing and Is Essential for Embryonic Development in Arabidopsis thaliana
Authors: Sasaki Taku , Kanno Tatsuo , Liang Shih-Chieh , Chen Pao-Yang , Liao Wen-Wei , Lin Wen-Dar , Matzke Antonius J M , Matzke Marjori 
Published: March 2015

Abstract
Alternative splicing is prevalent in plants, but little is known about its regulation in the context of developmental and signaling pathways. We describe here a new factor that influences pre-messengerRNA (mRNA) splicing and is essential for embryonic development in Arabidopsis thaliana. This factor was retrieved in a genetic screen that identified mutants impaired in expression of an alternatively spliced GFP reporter gene. In addition to the known spliceosomal component PRP8, the screen recovered Arabidopsis RTF2 (AtRTF2), a previously uncharacterized, evolutionarily conserved protein containing a replication termination factor 2 (Rtf2) domain. A homozygous null mutation in AtRTF2 is embryo lethal, indicating that AtRTF2 is an essential protein. Quantitative RT-PCR demonstrated that impaired expression of GFP in atrtf2 and prp8 mutants is due to inefficient splicing of the GFP pre-mRNA. A genome-wide analysis using RNA sequencing indicated that 13–16% of total introns are retained to a significant degree in atrtf2 mutants. Considering these results and previous suggestions that Rtf2 represents an ubiquitin-related domain, we discuss the possible role of AtRTF2 in ubiquitin-based regulation of pre-mRNA splicing.
Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease
Authors: Qin Wenning , Dion Stephanie L , Kutny Peter M , Zhang Yingfan , Cheng Albert W , Jillette Nathaniel L , Malhotra Ankit , Geurts Aron M , Chen Yi-Guang , Wang Haoyi 
Published: March 2015

AbstractThe clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas) system is an adaptive immune system in bacteria and archaea that has recently been exploited for genome engineering. Mutant mice can be generated in one step through direct delivery of the CRISPR/Cas9 components into a mouse zygote. Although the technology is robust, delivery remains a bottleneck, as it involves manual injection of the components into the pronuclei or the cytoplasm of mouse zygotes, which is technically demanding and inherently low throughput. To overcome this limitation, we employed electroporation as a means to deliver the CRISPR/Cas9 components, including Cas9 messenger RNA, single-guide RNA, and donor oligonucleotide, into mouse zygotes and recovered live mice with targeted nonhomologous end joining and homology-directed repair mutations with high efficiency. Our results demonstrate that mice carrying CRISPR/Cas9-mediated targeted mutations can be obtained with high efficiency by zygote electroporation.
Inventory of mammals in protected reserves and natural habitats of Tripura, northeast India with notes on existing threats and new records of Large Footed Mouse-eared Bat and Greater False Vampire Bat
Authors: Majumder Joydeb , Majumdar Koushik , Bhattacharjee Partha Pratim , Agarwala Basant Kumar 
Published: March 2015

Twenty-four species representing 21 genera, 16 families and 7 orders of mammals were recorded in the Tripura state, northeast India, from an inventory done from 2006 to 2012. Ten of these species were found in wildlife sanctuaries as well as in primary forests. Four species were recorded exclusively from the wildlife sanctuaries and ten species were recorded only from primary forests. Order Primates was the most diverse group represented by 6 species from 4 genera in 3 families. Frequency sightings data showed that 11 species were rare, 2 species were occasional, one species was frequent, and another 10 species were common. Two species, Large-footed Mouse-eared Bat, Myotis sp., and Greater False Vampire Bat, Megaderma lyra, are new records from the study area. Overall, 23 of the 24 species recorded are listed in the IUCN Red List, 14 species are listed in CITES, and 14 species are protected under the Indian Wildlife Protection Act, 1972. Threats being faced by many of the recorded mammals from human encroachments are highlighted.
Notes on rare clavarioid species (Fungi: Basidiomycota) in Patagonia, Argentina
Authors: Messuti María Inés , Lorenzo Laura Emma 
Published: March 2015

The distributions of two clavarioid species, Clavulinopsis laeticolor (Berk. and M.A. Curtis) R.H. Petersen (Agaricales, Clavariaceae) and Lentaria rionegrensis R.H. Petersen (Gomphales, Lentariaceae), are extended and updated. Both species are poorly known in Argentina, and specifically in Patagonia; these species were cited only once in the 1960s and 1990s, respectively.
First reports of Bactrophora dominans Westwood, 1842 (Orthoptera: Romaleidae) from Venezuela and French Guiana (South America), with comments on biology, ecology and distribution of the species
Authors: González Jorge Manuel , Shea Jeff , Brewer-Carías Charles 
Published: March 2015

New records of Bactrophora dominans Westwood, 1842 collected for the first time in Venezuela (Tepui Ichum), and French Guiana (Bélizon and Regina), are presented. Description of the insect, its colors, as well as ecological and biological notes and a historical overview of the known specimens in the genus and species are also included.
Editorial
Authors: Lima Jorge Dos Santos 
Published: March 2015

A DIALEKTIKÉ é um periódico de Filosofia do Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte (IFRN). Esta edição tematiza, entre outros, os seguintes pensadores: Dretske, Enrique Dussel, Foucault, Heidegger, Kant, Paul Ricoeur, Platão, Thomas Kuhn e Walter Benjamin. Neste volume (Vol. 1, 2014), além de autores do IFRN, há contribuições advindas de diversas instituições como o Instituto Federal de Educação, Ciência e Tecnologia Farroupilha, a Universidade Regional do Noroeste do Estado do Rio Grande do Sul, a Escola de Ciências e Tecnologias da Universidade Federal do Rio Grande do Norte, a Universidade Federal de Ouro Preto (UFOP), a Universidade Federal do Ceará e uma instituição estrangeira, a Université Montpellier 2/França. Desse modo, agradecemos a confiança dos autores e a colaboração dos avaliadores ad hoc e convidamos a todos vocês, pesquisadores ou não, a apreciarem nossa primeira edição com a leitura dos textos aqui publicados.
Bedeutung der Biotechnologie beim Rind in Europa
Authors: Stinshoff H. , Wrenzycki C. 
Published: March 2015

ZusammenfassungDie Biotechnologie in der Reproduktionsmedizin bietet vielfältige Anwendungsbereiche und beinhaltet ein hohes Innovationspotenzial bei Nutztieren. Angesichts der globalen Entwicklungen können die neuen Erkenntnisse und Techniken wichtige Hilfsmittel sein, um zukünftigen Herausforderungen besser begegnen zu können. So kann der Einsatz biotechnologischer Verfahren im Bereich der Tierproduktion die Versorgung der Bevölkerung mit ausreichenden Mengen qualitativ hochwertiger Nahrungsmittel gewährleisten. Tiergenetische Ressourcen lassen sich durch die Anlage von Sperma- und Embryonenbanken erhalten. Durch die frühzeitige Diagnose von Erbfehlern, die Erzeugung von Nachkommen mit vorherbestimmtem Geschlecht und die Vermeidung von Zuchttiertransporten durch die Versendung tiefgefrorener Embryonen kommt es zu einer Verbesserung des Tierschutzes. Eine besondere Anwendungsmöglichkeit bietet sich außerdem durch den Einsatz speziesübergreifender Modelle, die auch für die assistierten Reproduktionstechniken in der Humanmedizin eine wichtige Rolle spielen. Daraus resultiert nicht nur in Deutschland ein erhöhter Bedarf in der Nutzung der biotechnologischen Verfahren und deren Weiterentwicklung durch die Förderung von Forschungsprojekten.
Short-term Response of Holcus lanatus L. (Common Velvetgrass) to Chemical and Manual Control at Yosemite National Park, USA
Authors: Jones Laura J. , Ostoja Steven M. , Brooks Matthew L. , Hutten Martin 
Published: March 2015

AbstractOne of the highest priority invasive species at both Yosemite and Sequoia and Kings Canyon national parks is Holcus lanatus L. (common velvetgrass), a perennial bunchgrass that invades mid-elevation montane meadows. Despite velvetgrass being a high priority species, there is little information available on control techniques. The goal of this project was to evaluate the short-term response of a single application of common chemical and manual velvetgrass control techniques. The study was conducted at three montane sites in Yosemite National Park. Glyphosate spot-spray treatments were applied at 0.5, 1.0, 1.5, and 2.0% concentrations, and compared with hand pulling to evaluate effects on cover of common velvetgrass, cover of other plant species, and community species richness. Posttreatment year 1 cover of common velvetgrass was 12.1% ± 1.6 in control plots, 6.3% ± 1.5 averaged over the four chemical treatments (all chemical treatments performed similarly), and 13.6% ± 1.7 for handpulled plots. This represents an approximately 50% reduction in common velvetgrass cover in chemically- treated plots recoded posttreatment year 1 and no statistically significant reduction in hand pulled plots compared with controls. However, there was no treatment effect in posttreatment year 2, and all herbicide application rates performed similarly. In addition, there were no significant treatment effects on nontarget species or species richness. These results suggest that for this level of infestation and habitat type, (1) one year of hand pulling is not an effective control method and (2) glyphosate provides some level of control in the short-term without impact to nontarget plant species, but the effect is temporary as a single year of glyphosate treatment is ineffective over a two-year period.
β2‐Glycoprotein I‐Dependent Anti‐Cardiolipin Antibodies Associated With Periodontitis in Patients With Systemic Lupus Erythematosus
Authors: Wang Chen‐Ying , Chyuan I‐Tsu , Wang Ya‐Li , Kuo Mark Yen‐Ping , Chang Ching‐Wen , Wu King‐Jean , Hsu Ping‐Ning , Nagasawa Toshiyuki , Wara‐aswapati Nawarat , Chen Yi‐Wen 
Published: March 2015

Background: It was reported that patients with systemic lupus erythematosus (SLE) exhibited increased levels of anticardiolipin (anti‐CL) antibodies, a class of antiphospholipid antibodies associated with thrombosis. β2‐glycoprotein I (β2GPI) has been considered as the actual target antigen for anti‐CL antibodies. This study investigates the association of periodontal infection with anti‐CL antibodies in patients with SLE.Methods: Fifty‐three SLE female patients and 56 healthy female volunteers were recruited in this case‐control study. All participants received periodontal examinations. The presence of Porphyromonas gingivalis and Treponema denticola in saliva and plaque samples was detected by polymerase chain reaction. Levels of serum anti‐CL and anti‐β2GPI antibodies were examined using enzyme‐linked immunosorbent assay.Results: Patients with SLE exhibited more periodontal attachment loss and increased titers of serum anti‐CL and anti‐β2GPI antibodies compared with healthy controls. Patients with active SLE who harbored P. gingivalis or P. gingivalis together with T. denticola intraorally exhibited significantly higher anti‐CL and anti‐β2GPI antibodies than those without these bacteria. Anti‐CL and anti‐β2GPI antibody levels correlated positively with clinical attachment level. Furthermore, increased anti‐β2GPI antibody levels were significantly associated with C‐reactive protein and erythrocyte sedimentation rate.Conclusions: Elevated anti‐CL and anti‐β2GPI antibody levels were associated with periodontopathic bacteria and periodontal breakdown in patients with SLE. Periodontitis might be a modifiable risk factor for SLE.
Black Barley as a Means of Mitigating Deoxynivalenol Contamination
Authors: Choo Thin Meiw , Vigier Bernard , Savard Marc E. , Blackwell Barbara , Martin Richard , Wang Junmei , Yang Jianming , Abdel‐Aal El‐Sayed M. 
Published: March 2015

ABSTRACTFusarium head blight (FHB) is a destructive disease of barley (Hordeum vulgare L.) in many countries. The disease can result in mycotoxin contamination such as deoxynivalenol (DON) in the grain. The objective of this study was to determine if black barley is more resistant to DON accumulation than yellow barley as the former contains a high level of phenolic compounds. In one experiment, 100 recombinant inbred lines (RILs) were derived from each of the two barley crosses: AC Klinck/CH9403‐2 and AC Legend/CH9403‐2 with half of them being black and the other half yellow. These lines along with their parents were evaluated for resistance to DON accumulation under natural infection conditions at Harrington (Prince Edward Island) for 3 yr (2005–2007). They were also evaluated for resistance to FHB incidence and DON accumulation under artificial inoculation conditions at Ottawa (Ontario) in 2005 and 2006 and at Hangzhou (China) in 2005–2006. Black RILs on average contained 17 to 59% less DON than yellow RILs under natural conditions in both crosses in two tests. Black RILs had 2 to 20% lower FHB incidence than yellow RILs in both crosses in two tests and contained 16 to 18% less DON in one test. In another experiment, 26 hulless accessions were evaluated at Ottawa in 2011 and 2012. Black accessions on average contained 53% less DON than the yellow accessions in 2012 and they contained 46% less DON when the DON data were combined over 2 yr. In conclusion, black barley can be used as a means of mitigating DON contamination.
Reducing SCADA System Nuisance Alarms in the Water Industry in Northern Ireland
Authors: O'Donoghue Nigel , Phillips Debra H. , Nicell Ciaran 
Published: March 2015

ABSTRACT: The advancement of telemetry control for the water industry has increased the difficulty of managing large volumes of nuisance alarms (i.e., alarms that do not require a response). The aim of this study was to identify and reduce the number of nuisance alarms that occur for Northern Ireland (NI) Water by carrying out alarm duration analysis to determine the appropriate length of persistence (an advanced alarm management tool) that could be applied. All data were extracted from TelemWeb (NI Water's telemetry monitoring system) and analyzed in Excel. Over a 6‐week period, an average of 40 000 alarms occurred per week. The alarm duration analysis, which has never been implemented before by NI Water, found that an average of 57% of NI Water alarms had a duration of <5 minutes. Applying 5‐minute persistence, therefore, could prevent an average 26 816 nuisance alarms per week. Most of these alarms were from wastewater assets.
Comments by the Auditing Standards Committee of the Auditing Section of the American Accounting Association on The Institute of Internal Auditors' Proposed Enhancements to the International Professional Practices Framework (IPPF)
Authors: Anderson Urton L. , Christ Margaret H. , Janvrin Diane J. 
Published: March 2015

SUMMARY
According to the IIA, “The International Professional Practices Framework (IPPF) is the conceptual framework that organizes authoritative guidance promulgated by The Institute of Internal Auditors.” The IPPF includes overarching principles and standards of internal audit practice (e.g., the definition of internal audit, the code of ethics, the standards), as well as detailed guidance for carrying out specific activities (e.g., practice advisories). The IPPF is currently organized to differentiate between mandatory guidance and strongly recommended guidance for internal auditors as they carry out the responsibilities of the profession.
On August 4, 2014 the Institute of Internal Auditors (IIA) solicited public comments on its proposed enhancements to the International Professional Practices Framework (IPPF). This “relook” is intended to modify the existing structure of the IPPF so that it (1) “benefits IIA members, the internal audit profession as a whole, and its stakeholders,” and (2) strengthens “the IPPF's ongoing relevance for the foreseeable future.” The comment period ended November 3, 2014.
Selecting an Enterprise Resource Planning System: An Active Learning Simulation
Authors: Fulmer Bachman P. , Gerard Gregory J. 
Published: March 2015

ABSTRACT
This case provides an opportunity for students to engage in an active learning simulation of a company's enterprise resource planning (ERP) software selection process. Groups of students are assigned to represent management, advisors, and ERP software vendors, each playing their role in the process of identifying requirements, generating and evaluating a request for proposal (RFP), responding to an RFP and making a reasoned recommendation to the CEO and board of directors. The case encourages active learning and provides students a chance to exercise professional business writing and presentation skills. It also provides a unique opportunity to practice persuasive communication skills.
Effects of Acoustic Treatment on Music Teachers' Exposure to Sound
Authors: Kozłowski Emil , Młyński Rafał 
Published: March 2015

Abstract
In this study, music teachers' exposure to sound was tested by measuring the A-weighted equivalent sound pressure level (SPL), the A-weighted maximum SPL and the C-weighted peak SPL. Measurements were taken prior to and after acoustic treatment in four rooms during classes of trumpet, saxophone, French horn, trombone and percussion instruments. Results showed that acoustic treatment affects the exposure of music teachers to sound. Daily noise exposure levels (LEX, 8 h) for all teachers exceeded a limit of 85 dB while teaching music lessons prior to room treatment. It was found that the LEX, 8 h values ranged from 85.8 to 91.6 dB. The highest A-weighted maximum SPL and C-weighted peak SPL that music teachers were exposed to were observed with percussion instruments (LAmax = 110.4 dB and LCpeak = 138.0 dB). After the treatments, daily noise exposure level decreased by an average of 5.8, 3.2, 3.0, 4.2 and 4.5 dB, respectively, for the classes of trumpet, saxophone, French horn, trombone and drums, and did not exceed 85 dB in any case.