bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study
Authors: Sheehan Jason P. , Starke Robert M. , Mathieu David , Young Byron , Sneed Penny K. , Chiang Veronica L. , Lee John Y. K. , Kano Hideyuki , Park Kyung-Jae , Niranjan Ajay , Kondziolka Douglas , Barnett Gene H. , Rush Stephen , Golfinos John G. , Lunsford L. Dade 
Published: April 2013

Object
Pituitary adenomas are fairly common intracranial neoplasms, and nonfunctioning ones constitute a large subgroup of these adenomas. Complete resection is often difficult and may pose undue risk to neurological and endocrine function. Stereotactic radiosurgery has come to play an important role in the management of patients with nonfunctioning pituitary adenomas. This study examines the outcomes after radiosurgery in a large, multicenter patient population.

Methods
Under the auspices of the North American Gamma Knife Consortium, 9 Gamma Knife surgery (GKS) centers retrospectively combined their outcome data obtained in 512 patients with nonfunctional pituitary adenomas. Prior resection was performed in 479 patients (93.6%) and prior fractionated external-beam radiotherapy was performed in 34 patients (6.6%). The median age at the time of radiosurgery was 53 years. Fifty-eight percent of patients had some degree of hypopituitarism prior to radiosurgery. Patients received a median dose of 16 Gy to the tumor margin. The median follow-up was 36 months (range 1–223 months).

Results
Overall tumor control was achieved in 93.4% of patients at last follow-up; actuarial tumor control was 98%, 95%, 91%, and 85% at 3, 5, 8, and 10 years postradiosurgery, respectively. Smaller adenoma volume (OR 1.08 [95% CI 1.02–1.13], p = 0.006) and absence of suprasellar extension (OR 2.10 [95% CI 0.96–4.61], p = 0.064) were associated with progression-free tumor survival. New or worsened hypopituitarism after radiosurgery was noted in 21% of patients, with thyroid and cortisol deficiencies reported as the most common postradiosurgery endocrinopathies. History of prior radiation therapy and greater tumor margin doses were predictive of new or worsening endocrinopathy after GKS. New or progressive cranial nerve deficits were noted in 9% of patients; 6.6% had worsening or new onset optic nerve dysfunction. In multivariate analysis, decreasing age, increasing volume, history of prior radiation therapy, and history of prior pituitary axis deficiency were predictive of new or worsening cranial nerve dysfunction. No patient died as a result of tumor progression. Favorable outcomes of tumor control and neurological preservation were reflected in a 4-point radiosurgical pituitary score.

Conclusions
Gamma Knife surgery is an effective and well-tolerated management strategy for the vast majority of patients with recurrent or residual nonfunctional pituitary adenomas. Delayed hypopituitarism is the most common complication after radiosurgery. Neurological and cranial nerve function were preserved in more than 90% of patients after radiosurgery. The radiosurgical pituitary score may predict outcomes for future patients who undergo GKS for a nonfunctioning adenoma.
Spinal aneurysms: clinicoradiological features and management paradigms
Authors: Madhugiri Venkatesh S. , Ambekar Sudheer , Roopesh Kumar V. R. , Sasidharan Gopalakrishnan M. , Nanda Anil 
Published: April 2013

Object
Spinal aneurysms (SAs) are rare lesions. The clinicoradiological features and the exact degree of their association with comorbid conditions such as arteriovenous malformations (AVMs) and coarctation of the aorta have not been definitively described. The ideal management paradigm has not been established. The authors reviewed literature to determine the clinical patterns of presentation, management, and outcome of spinal aneurysms.

Methods
A systematic review of literature was performed using 23 separate strings. A total of 10,190 papers were screened to identify 87 papers that met the inclusion criteria. A total of 123 SAs could be included for analysis.

Results
The mean age of patients at presentation was 38 years; 10% of patients were aged less than 10 years and nearly 50% were greater than 38 years. Spinal aneurysms can be divided into 2 groups: those associated with AVMs (SA-AVMs, or Type 1 SAs) and those with isolated aneurysms (iSAs, or Type 2 SAs). Patients with Type 2 SAs were older and more likely to present with bleeding than those with Type 1 SAs. The acute syndromes can be divided into 3 groups of patients: those with spinal syndrome, those with cranial/craniospinal syndrome, and those with nonspecific presentation. Overall, 32.6% presented with angiography-negative cranial subarachnoid hemorrhage (SAH). Presentation with evidence of cord dysfunction (myelopathy/weakness/sensory loss/bladder involvement) correlated with poor outcome, as did presentation with hemorrhage and association with other comorbid conditions. Surgery and endovascular therapy both led to comparable rates of complete aneurysm obliteration for Type 2 SAs, whereas for the AVM-associated Type 1 SAs, surgery led to better rates of lesion obliteration. The authors propose a classification scheme for spinal aneurysms based on whether the lesion is solitary or is associated with a coexistent spinal AVM; this would also imply that the ideal therapy for the aneurysm would differ based on this association.

Conclusions
The clinical and radiological patterns that influence outcome are distinct for Type 1 and Type 2 SAs. The ideal treatment for Type 1 SAs appears to be excision, whereas surgery and endovascular therapy were equally effective for Type 2 SAs.
Surgical treatment of superior cluneal nerve entrapment neuropathy
Authors: Morimoto Daijiro , Isu Toyohiko , Kim Kyongsong , Imai Tetsuaki , Yamazaki Kazuyoshi , Matsumoto Ryoji , Isobe Masanori 
Published: April 2013

Object
Superior cluneal nerve (SCN) entrapment neuropathy is a poorly understood clinical entity that can produce low-back pain. The authors report a less-invasive surgical treatment for SCN entrapment neuropathy that can be performed with local anesthesia.

Methods
From November 2010 through November 2011, the authors performed surgery in 34 patients (age range 18–83 years; mean 64 years) with SCN entrapment neuropathy. The entrapment was unilateral in 13 patients and bilateral in 21. The mean postoperative follow-up period was 10 months (range 6–18 months). After the site was blocked with local anesthesia, the thoracolumbar fascia of the orifice was dissected with microscissors in a distal-to-rostral direction along the SCN to release the entrapped nerve. Results were evaluated according to Japanese Orthopaedic Association (JOA) and Roland-Morris Disability Questionnaire (RMDQ) scores.

Results
In all 34 patients, the SCN penetrated the orifice of the thoracolumbar fascia and could be released by dissection of the fascia. There were no intraoperative surgery-related complications. For all patients, surgery was effective; JOA and RMDQ scores indicated significant improvement (p < 0.05).

Conclusions
For patients with low-back pain, SCN entrapment neuropathy must be considered as a causative factor. Treatment by less-invasive surgery, with local anesthesia, yielded excellent clinical outcomes.
Consanguineous mating, specialization, and the environment: How multiple variable interactions affect the evolution of dioecy
Authors: Sinclair Jordan P. , Maxwell Glenn D. , Freeman D. Carl 
Published: April 2013

• Premise: The evolution of dioecy in plants is usually modeled as a consequence of self‐fertilization. While increased seed and pollen production and dispersal patterns of specialized unisexuals have been examined, mating among relatives and interaction effects have been largely ignored. Here, we examine multiple variables simultaneously providing a more ecologically realistic set of conditions favoring the evolution of dioecy.• Methods: We developed two complementary models to explore the evolution of dioecious plants. In both models, we examined the effects of inbreeding, compensation, and specialization on unisexual invasibility and were able to directly measure the influence of related matings on such a system.• Key results: Our results support previous studies indicating dispersal specialization, consanguineous mating, and inbreeding depression facilitate the evolution of dioecy. However, our results suggest that it is the interaction effect of multiple forces acting simultaneously that allows for unisexual invasion at thresholds and frequencies witnessed in nature. Additionally, our results suggest that subdioecious populations often result, and depending on population conditions, dioecy evolves at different rates, lending importance to the ecological and life history conditions of the species.• Conclusion: Mating among relatives significantly enhances the invasibility of a unisexual mutant into a hermaphroditic population and lowers the levels of inbreeding depression required for invasion than previously reported conditions for unisexual invasion especially, if we consider multiple pressures simultaneously.
Quand le luxe devient une question économique : retour sur la querelle du luxe du 18e siècle
Authors: Diemer Arnaud 
Published: April 2013

La condamnation ou l’apologie du luxe est une question classique et récurrente dans l’histoire des idées politiques et morales. De nos jours, elle continue de générer un ensemble d’émotions contradictoires. Afin de comprendre les tenants et aboutissants d’un tel débat, nous avons choisi de nous plonger dans l’histoire de la pensée économique, et plus précisément, dans la querelle du luxe qui est survenue durant le siècle des Lumières. Si le luxe est immoral, il n’est pas forcément détestable, il participe en effet à la circulation des richesses, au maintien d’une certaine industrie et à l’essor du commerce. Les prises de positions des philosophes (Mandeville, Condillac, Montesquieu, Hume, Rousseau) et des économistes (Melon, Quesnay, Smith, Say) semblent ainsi davantage refléter un changement de systèmes de valeurs (l’intérêt et l’utile supplantent le vice et la vertu) qu’un véritable procès des dépenses ostentatoires. Codes JEL : A11, A13, B11, B12, B30
Luxe, innovations et crise : les enseignements des économistes classiques
Authors: Ravix Joël Thomas 
Published: April 2013

L’article montre que les analyses des économistes classiques peuvent servir de cadre théorique pour expliquer le rôle économique du luxe. En effet, l’approche classique trouve son origine dans le débat sur les implications politiques du développement du commerce et du luxe, qui marque le 18 e siècle, mais l’oriente vers une conception particulière qui associe le luxe à une sorte d’innovation sociale pour expliquer l’enrichissement des nations. Elle se structure ensuite, dans la première moitié du 19 e siècle, autour des liens entre luxe, innovation technique et crise économique. Codes JEL : B11, B12, O30
L'industrie du luxe et l'économie de la connaissance
Authors: Foray Dominique 
Published: April 2013

Quelle est la place de l’industrie du luxe dans l’économie du savoir et quelle est sa contribution à la stratégie européenne de croissance fondée sur l’innovation et la connaissance (Europe 2020) ? Un des problèmes principaux que rencontre la plupart des pays européens réside dans leur difficulté à créer les conditions favorables à l’émergence d’innombrables systèmes d’innovation, à partir des éléments constitutifs des écologies du savoir (les organisations de recherche privées et publiques, les métiers créatifs, artisanaux et artistiques, les bureaux de conception et de style qui œuvrent à la création de connaissances nouvelles, technologiques, organisationnelles, artistiques, etc..). Pour différentes raisons (forme de la concurrence, nature positionnelle des biens, gouvernance économique, gestion des compétences), ce secteur crée une chimie particulière qui favorise la combinaison de multiples capacités de savoir pour innover. Il développe un espace économique favorable au sein duquel les éléments de différentes écologies du savoir se rencontrent pour mettre en œuvre de nombreux projets d’innovation. L’article conclut que la stratégie européenne 2020 ne sera pas possible sans la contribution des quelques secteurs qui excellent à identifier et valoriser certains éléments des écologies du savoir pour les mobiliser dans les systèmes d’innovation. Il importe donc d’identifier ces secteurs pour les placer au cœur de la politique industrielle et de l’innovation. Sans aucun doute, le secteur du luxe appartient à cette catégorie. Codes JEL : O30, O38, O52, E21
L'inexistence du luxe comme catégorie finie et unifiée : le classement hôtelier en France
Authors: Deschamps Marc 
Published: April 2013

Le luxe a, en particulier en France, un poids économique important tant en terme de valeur ajoutée que d’emplois et fait à ce titre l’objet de l’attention des pouvoirs publics. Les Etats généraux de l’Industrie ont ainsi conduit à la création d’un comité stratégique de filière qui lui est consacré. Pourtant, derrière l’apparente simplicité du vocable de « luxe » se cache une étonnante complexité. L’objet de cet article consiste dès lors à soutenir qu’il n’est pas possible de définir le luxe comme une catégorie finie et unifiée, notamment car il existe toujours une pluralité de logiques en action. Afin de le démontrer, l’article présente la réforme récente du classement hôtelier en France et en particulier la discontinuité attachée à la catégorie « palace ». Codes JEL : K10, L15, L83
Biens de luxe et innovations en économie socialiste : le cas des habanos
Authors: Herrera Rémy 
Published: April 2013

Cet article est consacré aux liaisons entre luxe et innovations dans le cadre d’une économie socialiste. Le cas des Habanos , cigares cubains haut de gamme, tout à fait singulier, en fournit l’application. Après une analyse des tendances majeures du secteur du tabac en général, et du tabac de grand luxe en particulier, dans le cas de Cuba, en première partie, l’accent est placé, dans une seconde partie, sur la coexistence de méthodes traditionnelles et des diverses formes d’innovations dans ce secteur. Ces innovations peuvent être d’ordre scientifique et technologique, ou bien liées aux processus de production ou aux produits. Codes JEL : O13, O31, P32, Q16.
Stratégies anti-contrefaçon des entreprises cosmétiques de luxe : accumulation versus valorisation du capital-savoir
Authors: Yacoub Nejla , Laperche Blandine 
Published: April 2013

Dans les cosmétiques de luxe, la contrefaçon est préjudiciable aux entreprises, affectées en termes d’image et de profitabilité. Lutter contre elle est donc un enjeu économique important. Dans cet article, nous étudions l’efficacité de l’innovation technologique comme stratégie anti-contrefaçon. L’objectif est de déterminer dans quelle mesure l’accumulation du capital-savoir permet aux entreprises cosmétiques de faire face à la contrefaçon et à ses impacts négatifs. Appuyant notre recherche par des exemples de marques leaders, telles que Dior , Chanel ou Yves Saint Laurent , nous démontrons que l’accumulation du capital-savoir est largement employée comme stratégie anti-contrefaçon, en parallèle aux stratégies de valorisation du capital-savoir existant. Codes JEL : L20, L66, O32, O34
Le jeu dramatique en classe de cinquième : pour un renouvèlement de l'enseignement du théâtre ?
Authors: Ailloud-Nicolas Catherine 
Published: April 2013

La réflexion proposée dans cet article s’appuie sur un corpus de manuels de cinquième qui s’intéressent aux nouveaux programmes. Tous se préoccupent d’enseigner le théâtre autrement, en particulier en prenant en compte le jeu et l’analyse de la représentation. Or cela pose un certain nombre de questions : i) Quelle articulation avec l’analyse littéraire ?, ii) Quelle conception du travail du comédien et du metteur en scène ? Les analyses concernant le collège seront aussi mises en perspective à partir d’études antérieures déjà conduites sur les manuels de lycée, le collège semblant poser d’autres problèmes didactiques spécifiques.
Quand l'enseignant et l'intervenant « théâtre » collaborent : une partition à écrire
Authors: Voltz Francine 
Published: April 2013

Aborder le théâtre en tant que pratique artistique avec des élèves de primaire et de collège soulève inévitablement la question de la place du corps, qu’il s’agisse du corps professionnel engagé dans une dynamique conjointe et du corps comme lieu d’une expérience sensible et culturelle, vécue au sein du groupe que constitue la classe. À partir d’exemples de collaborations menées par des enseignants des premier et second degrés et des intervenants théâtre en milieu rural et urbain depuis plusieurs années, l’article articule leurs analyses à la compétence « culture humaniste » du Socle commun. Soulevant la complexité de ce processus, il tente aussi de dégager, chez les élèves, les « attitudes » susceptibles de s’en trouver développées et enrichies.
Méthode d'évaluation de la qualité des espaces publics dans un projet d'aménagement durable à Alger
Authors: Hadji Lydia 
Published: April 2013

Cette contribution propose de définir une méthode d’évaluation de la qualité des espaces publics « QUEP » dans un projet d’aménagement, constituant un outil d’aide à la décision et à la conception, dans le cadre du développement durable. L’application de la méthode en phase intermédiaire sur un projet de pôle d’échanges à Alger, repose sur des critères et des indicateurs d’évaluation représentatifs de la qualité des espaces publics. Elle permet de mettre en lumière les défaillances et les qualités de ce projet au regard des exigences de la qualité des espaces publics.
Natural Convection in a Concentric Annulus: A Lattice Boltzmann Method Study with Boundary Condition-Enforced Immersed Boundary Method
Authors: Hu Yang , Niu Xiao-Dong , Shu Shi , Yuan Haizhuan , Li Mingjun 
Published: April 2013

AbstractIn this paper, a boundary condition-enforced IBM is introduced into the LBM in order to satisfy the non-slip and temperature boundary conditions, and natural convections in a concentric isothermal annulus between a square outer cylinder and a circular inner cylinder are simulated. The obtained results show that the boundary condition-enforced method gives a better solution for the flow field and the complicated physics of the natural convections in the selected case is correctly captured. The calculated average Nusselt numbers agree well with the previous studies.
The Sistah Powah Structured Writing Intervention: A Feasibility Study for Aging, Low-Income, HIV-Positive Black Women
Authors: DeMarco Rosanna F. , Chan Keith 
Published: April 2013

Purpose. The purpose of this study was to test the feasibility and assess outcomes of health care adherence based on whether participants engage in particular risky behaviors relevant to general health or living with human immunodeficiency virus (HIV) infection and the frequency of these adherent behaviors. Health adherent behaviors include both self-advocacy and decreased stigma as underlying key components. Design. A randomized control trial comparing peer-led attention control support and intervention groups. Setting. Community-based women's drop-in center in an urban, black neighborhood of Boston, Massachusetts. Subjects. Aging, low-income, black women living with HIV infection. Intervention. Peer-led, small-group, structured writing using film clips from Women's Voices Women's Lives as a writing prompt. Measures. Demographic and outcome data that included adherence, self-advocacy, and stigma; collected at baseline, 6 weeks, and 6 months. Analysis. Repeated-measures analysis of variance scores were examined between groups and waves. Paired-sample t-tests were used to examine mean differences across time. Results. Sample included 110 women (intervention, n = 56; comparison, n = 54). Retention was 85.5%. Repeated-measures analysis indicated intervention group condom use (n = 69, F = 8.02, df = 1, p < .01) and safe sex (n = 71, F = 13.02, df = 1, p < .01) was higher than that of comparison group. A time effect was also found in the Silencing the Self Scale (n = 91, Pillai's trace = 7.21, df = 2, p < .01). Conclusion. This study demonstrates the feasibility of a tailored, peer-led, and culturally relevant interventions and tentative efficacy in populations affected by health disparities. Key limitations include no comparison intervention format with women who can't write and the need to test generalizability.
Lifestyle Behavior Change and Repeat Health Risk Appraisal Participation: A Structural Equation Modeling Approach
Authors: Simpson Vicki L. , Hyner Gerald C. , Anderson James G. 
Published: April 2013

Purpose. Health risk appraisals (HRAs) have been used to address multiple health concerns and lifestyle behaviors. We explore the longitudinal relationship between emotional health, stage of change for five lifestyle behaviors, and lifestyle risks using HRA-generated data. Design. Secondary analysis of 3 years of HRA data. Setting. A large health care management services provider. Subjects. A total of 7535 adults employed across three companies who completed consecutive HRAs over a 3-year period. Measures. Self-report items concerning participant health, lifestyle behaviors, disease risk factors, job/life satisfaction, safety, and biometrics. Analysis. Structural equation modeling tested a hypothesized longitudinal, fully cross-lagged panel design. Results. Results indicated that greater numbers of physical and behavioral risks classified as high risk were associated with greater intention to change or an actual change in lifestyle behavior in the following year. In addition, poorer emotional health was associated with a higher number of risks. Conclusion. Data from repeat participation in HRAs can be useful in studying multiple risk behaviors and related health measures, supporting the design and evaluation of effective, individualized, and responsive health promotion activities for working adults.
Isolation of volatiles from Nigella sativa seeds using microwave‐assisted extraction: effect of whole extracts on canine and murine CYP1A
Authors: Liu Xue , Park Jong‐Hyouk , Abd El‐Aty A. M. , Assayed M. E. , Shimoda Minoru , Shim Jae‐Han 
Published: April 2013

ABSTRACTThe volatile components of Nigella sativa seeds were isolated using microwave‐assisted extraction (MAE) and identified using gas chromatography. Further investigations were carried out to demonstrate the effects of whole extracts on canine (dog) and murine (rat) cytochrome P450 1A (CYP1A). The optimal extraction conditions of MAE were as follows: 25 mL of water, medium level of microwave oven power and 10 min of extraction time. A total of 32 compounds were identified under the conditions using GC‐FID and GC‐MS. Thymoquinone (38.23%), p‐cymene (28.61%), 4‐isopropyl‐9‐methoxy‐1‐methyl‐1‐cyclohexene (5.74%), longifolene (5.33%), α‐thujene (3.88) and carvacol (2.31%) were the main compounds emitted from N. sativa seeds. Various extracts including pure compounds, essential oil, nonpolar partition, relatively high‐polar/nonpolar partition, and polar partition extracts effectively inhibited the reaction of ethoxyresorufin O‐de‐ethylation, which is specified for CYP1A activity both in dog and rat. This in vitro data should be heeded as a signal of possible in vivo interactions. The use of human liver preparations would considerably strengthen the practical impact of the data generated from this study. Copyright © 2013 John Wiley & Sons, Ltd.