bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mediating role of government ICT use on the nexus between ICT access and public sector performance
Authors: Dogbe Francis , Alhassan Muftawu Dzang , Adomako Raphael Boahen , Davies Ezekiel 
Published: July 2024

Purpose
This study aims to explore how government ICT use influences the relationship between ICT access and public sector performance globally. Previous research has mainly focused on the impact of ICT access on private firms' performance, measured by profitability. Moreover, previous studies have mostly examined the effect of ICT access on firms' performance within a single country. This study fills a gap in the literature by investigating how government ICT use mediates the connection between ICT access and public sector performance on a global scale.

Design/methodology/approach
The study develops and empirically validates a conceptual model based on the Technology, Organisation-Environment framework and archival data for 131 countries, using partial least squares-structural equation modelling.

Findings
The findings from the study shows a significant relationship between ICT access and Government ICT use. Also, there was positive relationship between ICT access and Public Sector Performance. In addition, there exist a significant relationship between Government use of ICT and Public Sector Performance. Furthermore, the mediating role of government ICT use on the impact of ICT access on public sector performance was significant.

Originality/value
This study is unique in that it explores the relationship between ICT access, government ICT use and public sector performance on a global scale. By using archival sources, this research findings can easily be replicated and applied to a larger population. Additionally, using the TOE framework, this study demonstrates how technology (ICT access) and organisation (government ICT use) impact public sector performance globally.
Personality, sex and capture biases: Challenges for predator monitoring and management
Authors: Johnstone Kyla C. , Price Catherine , Garvey Patrick M. 
Published: July 2024

Abstract

The behaviour of vertebrate pests, such as invasive species and nuisance native animals, towards control devices present a major challenge for wildlife managers. Physical devices, such as live capture or kill‐traps, serve as essential management tools, yet the efficacy of these devices can be compromised when some individuals fail to engage with devices, risking the failure of an entire management operation. A more nuanced understanding of how behavioural variability within target populations influences interactions with different device types is needed to improve the detectability of recalcitrant individuals that fail to engage with devices and are subsequently missed by research and management activities.

We tested the behavioural responses of 28 wild‐caught stoats Mustela erminea, a highly successful invader in Aotearoa New Zealand, to three devices representing a range of styles commonly used for mesopredator research and management (box trap, tunnel trap and head‐up trap).

We assessed the influence of stoat personality, sex and device type on susceptibility to devices (probability and latency to trigger) and found all had independent and interactive effects. In general, stoats which were shyer, less active, less exploratory and less neophiliac (low attraction to novelty) took significantly longer to trigger devices and had significantly lower probabilities of triggering devices.

The influence of boldness on the probability of stoats triggering devices during first encounter differed significantly by trap type, and the box and tunnel traps targeted opposite ends of the personality spectrum.

Trap recalcitrance (avoidance of the standard control measures) was greatest in shy female stoats and females generally had lower susceptibility to all devices compared to males.

Synthesis and applications: Targeting recalcitrant individuals may pose a considerable problem if a failure to trigger a trap result in a long‐term and generalised avoidance of devices. We emphasise the importance of accounting for inter‐individual differences in responses to devices, addressing the motivations of recalcitrant individuals during fieldwork and accounting for these differences during data interpretation.
THE POWER OF UNCERTIFIED URBAN LAND
Authors: Obeng‐Odoom Franklin , Haila Anne 
Published: July 2024

AbstractUncertified land abounds. The critical question is whether such land can provide security of tenure, access to finance, effective urban planning, and highest and best use. While much research contests the prospects and problems of conventional land title registration, the power of uncertified land is an issue rarely raised and, if done, hardly resolved holistically. Fundamentally still, economists, philosophers, urbanists and others continue to dispute such power, contending that certified and commodified land is the answer to urban problems. Such theoretical contests lead to the following bigger puzzles: (1) Do uncertified land tenure systems address questions of insecurity of tenure, access to finance, effective planning, and highest and best use, as claimed by the theory of ‘the commons in an age of uncertainty’? (2) Are the experiences of land title registration congruent with the theory of certified and commodified land? (3) Why do states pursue land title registration over other land policies? Thematic analysis of original data, collected between 2019 and 2023 in Bali, Indonesia, well documented as a place with an alternative land tenure system undergoing rapid commodification, helps to answer these questions. Our data seem to indicate that uncertified land can address the questions raised about security of land tenure, finance, effective planning, and highest and best use—prospects that elude certified and commodified land. The preference for the latter as the vision of land policy, we find, is rooted in political‐economic structures that favour, and are reproduced by, a transnational alliance of monopolists.
Renewal without replication: Expanding Durkheim's theory of disruptions via queer nightlife
Authors: Ghaziani Amin , Abrutyn Seth 
Published: July 2024

AbstractGay bars are closing in large numbers around the world, but institutional loss provides only a partial narrative for evaluating the larger field of nightlife. Drawing on 112 interviews, we argue that bar closures disrupted the field and consequently encouraged the visibility of alternate nightlife forms, called club nights. Unlike the fixed and emplaced model of bars, club nights are episodic and event‐based occasions that are renewing nightlife without replicating the format of the gay bar. By detailing the phenomenology of club nights, we develop a new Durkheimian theory of disruptions that explains how and why some members of a community are motivated to renew rather than replicate existing institutional structures. We bring our framework to organization, sexuality, and nightlife studies—subfields that seldom engage with Durkheim—while subjecting a foundational social theory to an empirical case that can push it forward in important ways.
Multiomic meta‐analysis suggests a correlation between steroid hormone‐related genes and litter size in goats
Authors: Liu Cheng‐Li , Mou Hui‐Long , Na Ri‐Su , Wang Xiao , Hu Peng‐Fei , Ceccobelli Simone , Huang Yong‐Fu , E Guang‐Xin 
Published: July 2024

AbstractLitter size is a key indicator of production performance in livestock. However, its genetic basis in goats remains poorly understood. In this work, a genome‐wide selection sweep analysis (GWSA) on 100 published goat genomes with different litter rates was performed for the first time to identify candidate genes related to kidding rate. This analysis was combined with the public RNA‐sequencing data of ovary tissues (follicular phase) from high‐ and low‐yielding goats. A total of 2278 genes were identified by GWSA. Most of these genes were enriched in signaling pathways related to ovarian follicle development and hormone secretion. Moreover, 208 differentially expressed genes between groups were obtained from the ovaries of goats with different litter sizes. These genes were substantially enriched in the cholesterol and steroid synthesis signaling pathways. Meanwhile, the weighted gene co‐expression network was used to perform modular analysis of differentially expressed genes. The results showed that seven modules were reconstructed, of which one module showed a very strong correlation with litter size (r = −0.51 and p‐value <0.001). There were 51 genes in this module, and 39 hub genes were screened by Pearson's correlation coefficient between core genes > 0.4, correlation coefficient between module members > 0.80 and intra‐module connectivity ≥5. Finally, based on the results of GWSA and hub gene Venn analysis, seven key genes (ACSS2, HECW2, KDR, LHCGR, NAMPT, PTGFR and TFPI) were found to be associated with steroid synthesis and follicle growth development. This work contributes to understanding of the genetic basis of goat litter size and provides theoretical support for goat molecular breeding.
In chronic spontaneous urticaria, increased Galectin‐9 expression on basophils and eosinophils is linked to high disease activity, endotype‐specific markers, and response to omalizumab treatment
Authors: Ji Jiang , Tang Minhui , Zhao Yue , Zhang Chuqiao , Shen Yu , Zhou Bin , Liu Cuiping , Maurer Marcus , Jiao Qingqing 
Published: July 2024

AbstractBackgroundGalectin‐9 (Gal‐9) has been implicated in allergic and autoimmune diseases, but its role and relevance in chronic spontaneous urticaria (CSU) are unclear.ObjectivesTo characterize the role and relevance of Gal‐9 in the pathogenesis of CSU.MethodsWe assessed 60 CSU patients for their expression of Gal‐9 on circulating eosinophils and basophils as well as T cell expression of the Gal‐9 receptor TIM‐3, compared them with 26 healthy controls (HCs), and explored possible links with disease features including disease activity (urticaria activity score, UAS), total IgE, basophil activation test (BAT), and response to omalizumab treatment. We also investigated potential drivers of Gal‐9 expression by eosinophils and basophils.ResultsOur CSU patients had markedly increased rates of circulating Gal‐9+ eosinophils and basophils and high numbers of lesional Gal‐9+ cells. High rates of blood Gal‐9+ eosinophils/basophils were linked to high disease activity, IgE levels, and BAT negativity. Serum levels of TNF‐α were positively correlated with circulating Gal‐9+ eosinophils/basophils, and TNF‐α markedly upregulated Gal‐9 on eosinophils. CSU patients who responded to omalizumab treatment had more Gal‐9+ eosinophils/basophils than non‐responders, and omalizumab reduced blood levels of Gal‐9+ eosinophils/basophils in responders. Gal‐9+ eosinophils/basophils were negatively correlated with TIM‐3+TH17 cells.ConclusionOur findings demonstrate a previously unrecognized involvement of the Gal‐9/TIM‐3 pathway in the pathogenesis CSU and call for studies that explore its relevance.
When ‘Can I help you?’ hurts: Roma experiences of everyday microaggressions in retail outlets
Authors: Nyul Boglarka , Kende Anna , Pántya József , Váradi Luca , Braverman Jeremy , Hushegyi Ádám , Csaba Sára , Lantos Nóra Anna , Hopkins Nick 
Published: July 2024

AbstractThe concept of microaggressions alerts us how majority group members' everyday behaviour can impact minorities negatively. Recently, some researchers have questioned the criteria for identifying microaggressions and rejected the concept's utility. We maintain that attending to minorities' everyday experiences is important and illustrate this through a three‐phase study with Roma in Hungary. First, we conducted interviews exploring their everyday interactional experiences (Phase 1, N = 17); second, Roma participants filmed (naturally occurring) interactions with majority group members (Phase 2, N = 10); third, we showed such filmed interactions to Roma focus groups and recorded their discussions (Phase 3, N = 28). Analysing these discussions, we focused on how the experience of surveillance when shopping (even when manifested in apparently helpful attention from shop assistants) impacted participants in ways that majority group members likely have little awareness of. Specifically, participants reported their need to (a) reflect on (and manage) their emotional reactions; (b) weigh a variety of strategic considerations as to how to respond; and (c) engage in in‐the‐moment interpretation as to the nature of the interaction. Such experiences negatively impact the use of public space and illustrate the value of adopting the minority's vantage point concerning the identification of microaggressive treatment.
The unfolded protein response machinery in glioblastoma genesis, chemoresistance and as a druggable target
Authors: Simbilyabo Lucette Z. , Yang Liting , Wen Jie , Liu Zhixiong 
Published: July 2024

AbstractBackgroundThe role of the unfolded protein response (UPR) has been progressively unveiled over the last decade and several studies have investigated its implication in glioblastoma (GB) development. The UPR restores cellular homeostasis by triggering the folding and clearance of accumulated misfolded proteins in the ER consecutive to endoplasmic reticulum stress. In case it is overwhelmed, it induces apoptotic cell death. Thus, holding a critical role in cell fate decisions.MethodsThis article, reviews how the UPR is implicated in cell homeostasis maintenance, then surveils the evidence supporting the UPR involvement in GB genesis, progression, angiogenesis, GB stem cell biology, tumor microenvironment modulation, extracellular matrix remodeling, cell fate decision, invasiveness, and grading. Next, it concurs the evidence showing how the UPR mediates GB chemoresistance‐related mechanisms.ResultsThe UPR stress sensors IRE1, PERK, and ATF6 with their regulator GRP78 are upregulated in GB compared to lower grade gliomas and normal brain tissue. They are activated in response to oncogenes and are implicated at different stages of GB progression, from its genesis to chemoresistance and relapse. The UPR arms can be effectors of apoptosis as mediators or targets.ConclusionRecent research has established the role of the UPR in GB pathophysiology and chemoresistance. Targeting its different sensors have shown promising in overcoming GB chomo‐ and radioresistance and inducing apoptosis.
NDC80/HEC1 promotes macrophage polarization and predicts glioma prognosis via single‐cell RNA‐seq and in vitro experiment
Authors: Ye Weijie , Liang Xisong , Chen Ge , Chen Qiao , Zhang Hao , Zhang Nan , Huang Yuanfei , Cheng Quan , Chen Xiaoping 
Published: July 2024

AbstractIntroductionGlioma is the most frequent and lethal form of primary brain tumor. The molecular mechanism of oncogenesis and progression of glioma still remains unclear, rendering the therapeutic effect of conventional radiotherapy, chemotherapy, and surgical resection insufficient. In this study, we sought to explore the function of HEC1 (highly expressed in cancer 1) in glioma; a component of the NDC80 complex in glioma is crucial in the regulation of kinetochore.MethodsBulk RNA and scRNA‐seq analyses were used to infer HEC1 function, and in vitro experiments validated its function.ResultsHEC1 overexpression was observed in glioma and was indicative of poor prognosis and malignant clinical features, which was confirmed in human glioma tissues. High HEC1 expression was correlated with more active cell cycle, DNA‐associated activities, and the formation of immunosuppressive tumor microenvironment, including interaction with immune cells, and correlated strongly with infiltrating immune cells and enhanced expression of immune checkpoints. In vitro experiments and RNA‐seq further confirmed the role of HEC1 in promoting cell proliferation, and the expression of DNA replication and repair pathways in glioma. Coculture assay confirmed that HEC1 promotes microglial migration and the transformation of M1 phenotype macrophage to M2 phenotype.ConclusionAltogether, these findings demonstrate that HEC1 may be a potential prognostic marker and an immunotherapeutic target in glioma.
Medical Distrust Among Kidney Transplant Candidates
Authors: Thompson Valerie L. , Li Yiting , Liu Yi , Hong Jingyao , Sharma Swati , Metoyer Garyn , Clark‐Cutaia Maya N. , Purnell Tanjala S. , Crews Deidra C. , Segev Dorry L. , McAdams‐DeMarco Mara 
Published: July 2024

ABSTRACTBackgroundMedical distrust may hinder kidney transplantation (KT) access. Among KT candidates evaluated for waitlisting, we identified factors associated with high distrust levels and quantified their association with waitlisting.MethodsAmong 812 candidates (2018–2023), we assessed distrust using the Revised Health Care System Distrust Scale across composite, competence, and values subscales. We used linear regression to quantify the associations between candidate and neighborhood‐level factors and distrust scores. We used Cox models to quantify the associations between distrust scores and waitlisting.ResultsAt KT evaluation, candidates who were aged 35–49 years (difference = 1.97, 95% CI: 0.78–3.16), female (difference = 1.10, 95% CI: 0.23–1.97), and Black (difference = 1.47, 95% CI: 0.47–2.47) were more likely to report higher composite distrust score. For subscales, candidates aged 35–49 were more likely to have higher competence distrust score (difference = 1.14, 95% CI: 0.59–1.68) and values distrust score (difference = 0.83, 95% CI: 0.05–1.61). Race/ethnicity (Black, difference = 1.42, 95% CI: 0.76–2.07; Hispanic, difference = 1.52, 95% CI: 0.35–2.69) was only associated with higher values distrust scores. Female candidates reporting higher rescaled values distrust scores (each one point) had a lower chance of waitlisting (aHR = 0.78, 95% CI: 0.63–0.98), whereas this association was not observed among males. Similarly, among non‐White candidates, each 1‐point increase in both rescaled composite (aHR = 0.87, 95% CI: 0.77–0.99) and values (aHR = 0.82, 95% CI: 0.68–0.99) distrust scores was associated with a lower chance of waitlisting, while there was no association among White candidates.ConclusionFemale, younger, and non‐White candidates reported higher distrust scores. Values distrust may contribute to the long‐standing racial/ethnic and gender disparities in access to KT. Implementing tailored strategies to reduce distrust in transplant care may improve KT access for groups that experience persistent disparities.
Gonadotropic Axis, Bone Mass, and Sarcopenia Assessment After Autologous Hematopoietic Stem Cell Transplantation for Lymphoma
Authors: Leal Christianne Tolêdo de Souza , Souza Viviane Angelina de , Ferreira Júlia Diniz , Zanini Alexandre , Santos Kelli Borges dos , Ezequiel Danielle Guedes Andrade , Neto Abrahão Elias Hallack 
Published: July 2024

ABSTRACTGonadal dysfunction, the most frequent endocrine complication in both sexes after autologous hematopoietic cell transplant (HCT) could increase bone loss and sarcopenia, a disease characterized by reduced muscle strength and mass. Sarcopenia is associated with worse survival, lower remission rates, and progression‐free survival in patients with lymphoma after HCT. Low bone mass affected approximately 20% of the transplanted patients within 2 years and harms quality of life. This study was conducted in a single center and identified a strong relationship with patients transplanted more recently by LEC (lomustine, etoposide, and cyclophosphamide) conditioning regimen with sarcopenia. Peripheral neuropathy and bone mass changes were also associated with sarcopenia as well, suggesting a relationship with muscle strength loss.
1097. Epipactis palustris (L.) Crantz
Authors: Fay Michael F. , Raistrick Reinhild , Sayers Brendan 
Published: July 2024

SummaryEpipactis palustris (L.) Crantz (marsh helleborine), one of the showiest orchid species native to Britain and Ireland, is illustrated from plants growing in dune slacks on Lindisfarne island in Northumberland; a detailed description is given.
Normoalbuminuria—is it normal? The association of urinary albumin within the ‘normoalbuminuric’ range with adverse cardiovascular and mortality outcomes: A systematic review and meta‐analysis
Authors: Sehtman‐Shachar Dvora R. , Yanuv Ilan , Schechter Meir , Fishkin Alisa , Aharon‐Hananel Genya , Leibowitz Gil , Rozenberg Aliza , Mosenzon Ofri 
Published: July 2024

AbstractAimTo assess the association between urinary albumin‐to‐creatinine ratio (UACR) categories within the normal range with mortality and adverse cardiovascular outcomes.Materials and MethodsPubMed and Embase were systematically searched for real‐world evidence studies. Studies were manually evaluated according to predefined eligibility criteria. We included prospective and retrospective cohort studies of the association between UACR categories <30 mg/g and cardiovascular outcomes or mortality. Published information regarding study design, participants, UACR categorization, statistical methods, and results was manually collected. Two UACR categorization approaches were defined: a two‐category (UACR <10 mg/g vs. 10‐30 mg/g) and a three‐category division (UACR <5 mg/g vs. 5‐10 and 10‐30 mg/g). A random effects meta‐analysis was performed on studies eligible for the meta‐analysis.ResultsIn total, 22 manuscripts were identified for the systematic review, 15 of which were eligible for the meta‐analysis. The results suggest an association between elevated UACR within the normal to mildly increased range and higher risks of all‐cause mortality, cardiovascular death, and coronary heart disease, particularly in the range of 10‐30 mg/g. Compared with UACR <10 mg/g, the hazard ratio [HR (95% confidence interval, CI)] for UACR between 10 and 30 mg/g was 1.41 (1.15, 1.74) for all‐cause mortality and 1.56 (1.23, 1.98) for coronary heart disease. Compared with UACR <5 mg/g, the risk of cardiovascular mortality for UACR between 10 and 30 mg/g was more than twofold [HR (95% CI): 2.12 (1.61, 2.80)]. Intermediate UACR (5‐10 mg/g) was also associated with a higher risk of all‐cause mortality [HR (95% CI): 1.14 (1.05, 1.24)] and cardiovascular mortality [HR (95% CI): 1.50 (1.14, 1.99)].ConclusionsWe propose considering higher UACR within the normoalbuminuric range as a prognostic factor for cardiovascular morbidity and mortality. Our findings underscore the clinical significance of even mild increases in albuminuria.