bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study of subtalar arthrodesis after calcaneal frature malunion with autologous bone graft or freeze-dried xenograft
Authors: Henning Carlo , Poglia Gabriel , Leie Murilo Anderson , Galia Carlos Roberto 
Published: May 2015

Abstract

Background
Calcaneal fracture malunion may evolve into arthrosis and severe foot deformities. The aim of this study was to identify differences in bony union following corrective subtalar arthrodesis with interposition of autologous tricortical bone graft or freeze-dried bovine xenograft.

Methods
We prospectively evaluated 12 patients who underwent subtalar arthrodesis, six patients received autografts and 6 received freeze-dried bovine xenografts. After a mean followup of 58 weeks, the patients were clinical assessed using AOFAS scale and the visual analog scale (VAS) for pain and for final radiographic parameters measurement. Two blind raters evaluated the length of time required for solid union of the arthrodesis and graft integration by retrospective radiographic examination.

Results
In the autograft group, AOFAS score improved from a preoperative average of 37 to 64 points postoperatively (p = 0.02) and mean VAS score improved from 4.7 to 1.9 (p = 0.028). In the xenograft group, AOFAS score improved from 38 to 74 points (p = 0.02) and VAS from 5.5 to 2.7 (p = 0.046). Solid union was achieved in all cases in the autograft group at an average of 5.3 weeks and in five cases in the xenograft group at 8.8 weeks (p = 0.077). Graft integration occurred after an average of 10.7 weeks in the autograft group and 28.8 weeks in the xenograft group (p = 0.016).

Conclusion
With the numbers available, no significant difference could be detected in the length of time required for solid union of subtalar arthrodesis between groups, although time to integration of freeze-dried bovine xenografts was statistically higher. Clinical and functional improvement was observed in both groups.
Duration of psychological therapy: Relation to recovery and improvement rates in UK routine practice
Authors: Stiles William B. , Barkham Michael , Wheeler Sue 
Published: May 2015

BackgroundPrevious studies have reported similar recovery and improvement rates regardless of treatment duration among patients receiving National Health Service (NHS) primary care mental health psychological therapy.AimsTo investigate whether this pattern would replicate and extend to other service sectors, including secondary care, university counselling, voluntary sector and workplace counselling.MethodWe compared treatment duration with degree of improvement measured by the Clinical Outcomes in Routine Evaluation – Outcome Measure (CORE-OM) for 26 430 adult patients who scored above the clinical cut-off point at the start of treatment, attended 40 or fewer sessions and had planned endings.ResultsMean CORE-OM scores improved substantially (pre–post effect size 1.89); 60% of patients achieved reliable and clinically significant improvement (RCSI). Rates of RCSI and reliable improvement and mean pre- and post-treatment changes were similar at all tested treatment durations. Patients seen in different service sectors showed modest variations around this pattern.ConclusionsResults were consistent with the responsive regulation model, which suggests that in routine care participants tend to end therapy when gains reach a good-enough level.
The monodromy representation and twisted period relations for Appell’s hypergeometric function F4
Authors: Goto Yoshiaki , Matsumoto Keiji 
Published: May 2015

AbstractWe consider the system F4 (a, b, c) of differential equations annihilating Appell's hypergeometric series F4(a,b,c;x). We find the integral representations for four linearly independent solutions expressed by the hypergeometric series F4. By using the intersection forms of twisted (co)homology groups associated with them, we provide the monodromy representation of F4(a, b, c) and the twisted period relations for the fundamental systems of solutions of F4.
Molecular characterization of hepatocarcinogenesis using mouse models
Authors: Teoh Wei Wei , Xie Min , Vijayaraghavan Aadhitthya , Yaligar Jadegoud , Tong Wei Min , Goh Liang Kee , Sabapathy Kanaga 
Published: May 2015

ABSTRACT
Hepatocellular carcinoma (HCC) is a deadly disease, often unnoticed until the late stages, when treatment options become limited. Thus, there is a crucial need to identify biomarkers for early detection of developing HCC, as well as molecular pathways that would be amenable to therapeutic intervention. Although analysis of human HCC tissues and serum components may serve these purposes, inability of early detection also precludes possibilities of identification of biomarkers or pathways that are sequentially perturbed at earlier phases of disease progression. We have therefore explored the option of utilizing mouse models to understand in a systematic and longitudinal manner the molecular pathways that are progressively deregulated by various etiological factors in contributing to HCC formation, and we report the initial findings in characterizing their validity. Hepatitis B surface antigen transgenic mice, which had been exposed to aflatoxin B1 at various stages in life, were used as a hepatitis model. Our findings confirm a synergistic effect of both these etiological factors, with a gender bias towards males for HCC predisposition. Time-based aflatoxin B1 treatment also demonstrated the requirement of non-quiescent liver for effective transformation. Tumors from these models with various etiologies resemble human HCCs histologically and at the molecular level. Extensive molecular characterization revealed the presence of an 11-gene HCC-expression signature that was able to discern transformed human hepatocytes from primary cells, regardless of etiology, and from other cancer types. Moreover, distinct molecular pathways appear to be deregulated by various etiological agents en route to formation of HCCs, in which common pathways converge, highlighting the existence of etiology-specific as well as common HCC-specific molecular perturbations. This study therefore highlights the utility of these mouse models, which provide a rich resource for the longitudinal analysis of molecular changes and biomarkers associated with HCC that could be exploited further for therapeutic targeting.
Phylogenetic affinities of Myrioneuron and Cyanoneuron , generic limits of the tribe Argostemmateae and description of a new Asian tribe, Cyanoneuroneae (Rubiaceae)
Authors: Ginter Anna , Razafimandimbison Sylvain G. , Bremer Birgitta 
Published: May 2015

AbstractArgostemmateae (Rubiaceae, subfam. Rubioideae) are a mostly tropical Asian group of about 200 species currently classified in four morphologically distinct genera (Argostemma, Mouretia, Mycetia, Neohymenopogon). The monophyly of the tribe and Mycetia is strongly supported by molecular data, however, the tropical Asian genus Myrioneuron, traditionally associated with Mycetia based on its berry fruits, has not previously been investigated. The Bornean and Sulawesian genus Cyanoneuron, described based on the species of Myrioneuron with drupaceous fruits, had not been sequenced. Therefore, the phylogenetic positions of Cyanoneuron and Myrioneuron within Rubiaceae and their generic status have yet to be assessed with molecular data. These genera have tentatively been placed in tribe Spermacoceae (Rubioideae). We reconstructed a robust phylogeny of Rubioideae with sequence data from five plastid regions of 176 accessions and using the Bayesian Markov chain Monte Carlo and parsimony methods. Once the positions of Cyanoneuron and Myrioneuron were revealed, a robust phylogeny of the Spermacoceae alliance was reconstructed with the combined plastid and nuclear data (nrETS, nrITS) from 61 accessions to reassess its tribal limits. Mycetia and Myrioneuron are non–monophyletic and intermixed, and formed a well–supported clade diagnosed by berry fruits. We formally transfer Myrioneuron to Mycetia (older name), and present nine new combinations in the latter genus. Cyanoneuron was resolved with high support as monophyletic, and appears to be closely related to the Chinese monogeneric tribes Foonchewieae and Dunnieae. A new tribe Cyanoneuroneae is described to accommodate Cyanoneuron. This tribe is morphologically distinct from related tribes by its stipules apically divided into multiple linear segments, condensed–cymose inflorescences and drupe–like fruits with numerous small seeds. A new key to the genera of Argostemmateae is provided.
Matematization Elements of Theoretical Fundamentals of Descriptive Geometry
Authors: Панчук  , Panchuk K. , Юрков  , Yurkov V. , Волков  , Volkov V. , Кайгородцева  , Kaygorodtseva N. 
Published: May 2015

Active development of engineering and technology
rightly necessitates reform of higher education. If before teacher
was enough to make a course of lectures and read it throughout his
labor activity, but now, in a time of rapid change reality necessary
periodically rebuild the curriculum, focusing on the achievements
of modern science and emerging technologies. Impossible further
to teach tomorrow´s to engineers yesterday´s the provisions and
former methods. Today for engineer it is important the acquisition
of modern professional competencies with the ability to self-develop
the skills required and if necessary, switch to popular types of
activities. Therefore, modern engineering and technical education
must firstly be adequate to modern scientific and technological
reality, and secondly is based on modern scientific basis and regulations
and not &#34;braked&#34; with classic content and with traditional
techniques. Classical descriptive geometry, which in its time had
an active influence on the development of production and industry
initially in France and then throughout the world, today in the
digital age of information must be updated, to enrich scientific
achievements of modern scientists geometry and thereby become
a popular academic discipline.
Article is devoted to development of descriptive geometry in
the direction of the fundamental mathematical ideas – sets, relations,
algebraic operations; concepts – figures, conditions; analysis
of the logical foundations. The authors suggested the development
of elementary and higher descriptive geometry, uniting the known
facts, methods and algorithms and leading them into a system based
on common mathematical and logical ideas. From this perspective,
we consider three section of descriptive geometry: search for linear
objects based on the analysis of conditions, designing of surfaces,
solution of position tasks.
No statistically significant kinematic difference found between a cruciate-retaining and posterior-stabilised Triathlon knee arthroplasty
Authors: Hunt N. C. , Ghosh K. M. , Blain A. P. , Rushton S. P. , Longstaff L. M. , Deehan D. J. 
Published: May 2015

The aim of this study was to compare the maximum laxity conferred by the cruciate-retaining (CR) and posterior-stabilised (PS) Triathlon single-radius total knee arthroplasty (TKA) for anterior drawer, varus–valgus opening and rotation in eight cadaver knees through a defined arc of flexion (0º to 110º). The null hypothesis was that the limits of laxity of CR- and PS-TKAs are not significantly different. The investigation was undertaken in eight loaded cadaver knees undergoing subjective stress testing using a measurement rig. Firstly the native knee was tested prior to preparation for CR-TKA and subsequently for PS-TKA implantation. Surgical navigation was used to track maximal displacements/rotations at 0º, 30º, 60º, 90º and 110° of flexion. Mixed-effects modelling was used to define the behaviour of the TKAs. The laxity measured for the CR- and PS-TKAs revealed no statistically significant differences over the studied flexion arc for the two versions of TKA. Compared with the native knee both TKAs exhibited slightly increased anterior drawer and decreased varus-valgus and internal-external roational laxities. We believe further study is required to define the clinical states for which the additional constraint offered by a PS-TKA implant may be beneficial. Cite this article: Bone Joint J 2015; 97-B:642–8.
Assessment as learning: Lessons from the art and design studio
Authors: Granville Gary 
Published: May 2015

Abstract
The contemporary rhetoric of education policy is replete with references to problem solving, divergent thinking, learning from and through failure, risk-taking and similar desired qualities of education. Yet the connection between the ‘new’ rhetoric of education policy and the established language of art and design is rarely made. This is especially true in matters of student assessment. Perhaps the truth is that much of the rhetoric of education policy is presented in a deceptive discourse of criticality that masks an essentially different policy orientation: a ‘command-economy’ model of education. Educationists generally, and art and design educationists in particular, have been weak in challenging or at least questioning the new globalized orthodoxies. This article addresses the fault lines between these fields, with particular reference to the visual arts and suggests some options and implications for education policy. A brief introduction to the curriculum context in Ireland is provided in the first section. The second section comprises the main body: a discussion of fifteen principles of assessment that are derived from the literature of the past few decades. These fifteen principles are grouped in four categories and these are discussed in terms of their implications for curriculum structure and their resonance to with art and design education. The third and final section is a brief reflection on the potential of art and design education to inform general curriculum policy.
Rapid And Sensitive Detection Of Lawsonia Intracellularis In Pigs By Real-Time Loop-Mediated Isothermal Amplification
Authors: Byung-Yong PARK , Kwan-Seob SHIM , Won-Il KIM , Md Mukter HOSSAIN , Bumseok KIM , Jungkee KWON , Choi-Kyu PARK , Sung-Jin CHO , Inho JO , Ho-Seong CHO 
Published: May 2015

Abstract
A simple and rapid real-time loop-mediated isothermal amplification (LAMP) assay designed to detect Lawsonia (L.) intracellularis, an important bacteria causing proliferative enteropathy in pigs. A set of four primers targeting the ubiquinone/menaquinone biosynthesis methylase (ubiE) gene was designed for the LAMP reaction. Additionally, serial 10-fold dilutions of cultured L. intracellularis and spiked feces were also used for the optimization of real-time LAMP. The lower limit of the linear range of the assay in L. intracellularis was 1.0 × 100
L. intracellularis. Real-time LAMP was 10 and 100 times more sensitive than real-time PCR and conventional PCR detection methods, respectively. Based on testing of 213 porcine fecal samples using real-time LAMP, realtime PCR and PCR, the agreement quotients of real-time LAMP with conventional PCR and with real-time PCR were 0.77 and 0.95, respectively. This study demonstrated that real-time LAMP was a powerful tool for the rapid and sensitive detection of L. intracellularis in porcine fecal samples.
Proliferation And Differentiation Potential Of Canine Synovial Fluid Cells
Authors: Jelena FRANCUSKI V , Jasmina DEBELJAK MARTAČIĆ , Anita RADOVANOVIĆ , Nenad ANDRIĆ , Sophie SOURICE-PETIT , Jerome GUICHEUX , Slavko MOJSILOVIĆ , Milica KOVAČEVIĆ FILIPOVIĆ 
Published: May 2015

Abstract
The aim of this study was to determine whether synovial fluid (SF) of dogs contains cells that have characteristics of MSCs and to describe their differentiation potential. SF adherent cells from 5 young German shepherd dogs (average 3.8 ± 0.9 years) were expanded (37°C, 5% CO2, humidified atmosphere) three weeks before their phenotype was characterized by flow-cytometry for the presence of CD90 and CD34. Population doubling time (PDT), number of CFU-F and adipogenic, osteogenic and chondrogenic potentials have been determined in vitro. In early passages PTD was 31 ± 10 hours and expansion fold after 3 sub cultivations (9 days) theoretically could be 372 ± 134. At P1, 0.55 ± 0.05% of SF cells had the ability to form CFU-F. Sixty-six percent of cells expressed CD90 and none of the cells expressed markers of hematopoietic cells. Oil Red O staining has shown accumulation of fat droplets in cells grown in adipogenic medium, while deposits of calcium in the osteogenic medium were evidenced with Alizarin red staining. SF cultured in hondrogenic and control medium in three-dimensional conditions formed a cartilage-like tissue. Alcian blue staining of pellets’ slides have shown a significant amount of glycosaminoglycans (GAGs) and immunohistochemistry analysis documented collagen type II expression. The amount of GAGs in pellets grown in both conditions showed no difference. SF cells in vitro exhibited osteogenic, adipogenic and chondrogenic differentiation potentials, suggesting the presence of different mesenchymal progenitors. These results also demonstrated that SF cells have a spontaneous chondrogenic potential that should be further explored for possible tissue engineering protocols.
Molecular Characterization Of Autochtonus Slavonian Syrmian Podolian Cattle
Authors: Tomislav KEROS , Lorena JEMERŠIĆ , Jelena PRPIĆ , Dragan BRNIĆ 
Published: May 2015

Abstract
The aim of the study is to increase the knowledge on the genetic structure status of the autochthonous Slavonian Syrmian Podolian cattle breed currently listed by the FAO as “critically endangered”. Blood samples obtained from a total of 20 randomly selected individua were included in genotyping upon microsatellite panel recommended by ISAG and FAO. The procedure enabled the identification of as many as 214 (96.34%) genotypes and, at the same time, 129 allelic variations were found with = 11.73 alleles per locus. The genotypes showed differences between the microsatellite loci and also significant differences (p<0.05) in the frequency of both homozygosity and heterozygosity. The analyses of the allelic distribution within microsatellite loci showed marked variability. The distribution of genetic relationship was expressed by Wright's F coefficients. A moderate level of genetic diversity was observed at the tested loci. The findings demonstrate the degree of breed relationship and breed purity but also indicate that gene pool of the tested population has been threatened. Therefore, urgent measures must be taken to support both the genetic consolidation and preservation of the remaining population of Slavonian Syrmian Podolian cattle in Croatia.
Project of Hip Joint Endoprosthesis for an Individual Patient with Materials Selection
Authors: Bartmański M. , Świeczko-Żurek B. 
Published: May 2015

Abstract
Nowadays the joint replacement orthopaedic surgery is most frequently performed surgery associated with the damage of the join surface. The implantation is mainly placed in hip and knee area. This work includes the hip replacement design, based on the patient's medical records, the description of creation process and materials used for individual components.
Certain non-linear differential polynomials sharing a non zero polynomial
Authors: Majumder Sujoy 
Published: May 2015

Abstract
In this paper with the notion of weighted sharing of values we study the uniqueness of nonlinear differential polynomials of meromorphic
functions sharing a nonzero polynomial and obtain two results which improves and generalizes the results due to L. Liu [Uniqueness of meromorphic functions and differential polynomials, Comput.
Math. Appl., 56 (2008), 3236-3245.] and P. Sahoo [Uniqueness and weighted value sharing of meromorphic functions, Applied. Math. E-Notes., 11 (2011), 23-32.].
Liver X receptors as regulators of metabolism
Authors: Korach-André Marion , Gustafsson Jan-Åke 
Published: May 2015

Abstract
The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they regulate gene transcription and thereby mediate changes in metabolic pathways. Modulation of LXR and their downstream targets has appeared to be a promising treatment for metabolic diseases especially atherosclerosis and cholesterol metabolism. However, the complexity of LXR action in various metabolic tissues and the liver side effect of LXR activation have slowed down the interest for LXR drugs. In this review, we summarized the role of LXR in the main metabolically active tissues with a special focus on obesity and associated diseases in mammals. We will also discuss the dual interplay between the two LXR isoforms suggesting that they may collaborate to establish a fine and efficient system for the maintenance of metabolism homeostasis.
Thrombin generation, D-dimer and protein S in uncomplicated pregnancy
Authors: Kovac Mirjana K. , Lalic-Cosic Sanja Z. , Dmitrovic Jelena M. , Djordjevic Valentina J. , Radojkovic Dragica P. 
Published: May 2015

AbstractGestational age-specific reference values are essential for the accurate interpretation of haemostatic tests during pregnancy.Our 1-year prospective study included 40 healthy pregnant women with a median age of 30 (range 22–40) years; the subjects were followed in order to establish the gestational age dependent values for endogenous thrombin potential (ETP), D-dimer and protein S (activity and free).During the first trimester 50% of studied women had ETP >100% (reference values out of pregnancy); in the second trimester an ETP over 100% was observed in all women; ETP values remained unchanged during the third trimester. In the first trimester, the median D-dimer concentration of 0.30 mg/L, in the second 0.91 mg/L and in the third of 1.45 mg/L were observed. During the first trimester 14/40 subjects had protein S activity below reference range (<59%, out of pregnancy); the median value of 61.35; interquartile range (IQR) 20.38; in the second 21/37; the median value of 53.1 (IQR 15.65); in the third trimester 28/37 had low level of protein S activity with the median value of 49.0 (IQR 18.8). Free protein S showed a slight decrease from the first trimester; it remained almost stable during the rest of pregnancy, with the equal number of pregnant women with reduced free protein S.Related to the gestational age, a significant increase of ETP and D-dimer, from the second trimester was observed; the decrease of protein S was observed already from the early pregnancy, with more pronounced variability of protein S activity.