bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERCEPÇÃO E VALORAÇÃO DOS DESASTRES CLIMÁTICOS NATURAIS EM JARAGUÁ DO SUL/SC NOS ANOS DE 2008 E 2011
Authors: Amaro da Silva Felipe , Luiz Pinto André , Aparecida Alves Camila 
Published: February 2015

Resumo: O Município de Jaraguá do Sul vem sofrendo ao longo dos anos pelos constantes desastres ambientais, nesse estudo priorizaram-se os casos dos anos de 2008 e 2011. Para entender o processo traumático de um desastre buscou-se enfatizar a percepção da população de Jaraguá do Sul frente aos desastres, foram levantados dados com base na percepção e interpretação após um desastre ambiental, e suas diferentes percepções sobre o desastre. Após entendermos a percepção de uma população traumatizada, podemos compreender a fundo o que é um desastre, juntamente com os estudos científicos já realizados sobre essa questão, à percepção vem agregar valores a sociedade. O Município localiza-se, em um vale da Serra do Mar que apresenta vulnerabilidade a processos naturais de desnudação que, dadas as condições climáticas, geológicas, geomorfológicas e de ocupação antrópica aumentam o risco de ocorrências de desastres naturais como inundações e movimentos de massa. O município de Jaraguá do Sul declarou situação de emergência em 20 de novembro de 2008 e, posteriormente Estado de Calamidade Pública em 14 de dezembro do mesmo ano. Já no ano de 2011, precisamente no mês de janeiro e fevereiro o município entrou em estado de alerta, com riscos de enchentes e deslizamentos. Palavras–chave: Jaraguá do Sul. Percepção Ambiental. Percepção de Risco. Evento Climático Extremo.
VULNERABILIDADE NO MUNICÍPIO DE JARAGUÁ DO SUL SC: ESTUDO DOS EFEITOS DAS CHUVAS DE 2008
Authors: Amaro da Silva Felipe , Luiz Pinto André 
Published: February 2015

Resumo: O Município de Jaraguá do Sul vem sofrendo ao longo dos anos pelos constantes desastres ambientais, nesse estudo priorizou-se o caso do ano de 2008. O Município localiza-se, em um vale da Serra do Mar que apresenta vulnerabilidade a processos naturais de desnudação que, dadas as condições climáticas, geológicas, geomorfológicas e de ocupação antrópica aumentam o risco de ocorrências de desastres naturais como inundações e movimentos de massa. O município de Jaraguá do Sul declarou situação de emergência em 20 de novembro de 2008 e, posteriormente Estado de Calamidade Pública em 14 de dezembro do mesmo ano. Palavras–chave: Jaraguá do Sul. Desastres Naturais. Evento Climático Extremo.
The Effect of Auditing Standard No. 5 on Audit Report Lags
Authors: Mitra Santanu , Song Hakjoon , Yang Joon Sun 
Published: February 2015

SYNOPSIS
Auditing Standard No. 5 (AS5) introduced by the Public Company Accounting Oversight Board (PCAOB) in June 2007 requires a top-down risk-based approach in auditing and is expected to improve audit efficiency and make the overall auditing process timelier by reducing audit report lags. We investigate the impact of AS5 on audit report lags over an extended period from 2006 to 2011 and find that audit report lags are lower in the AS5 years (2007–2011) relative to the AS2 years (2006–2007). But this reduction is evident mostly for the firms with clean SOX 404 opinions. The presence of material internal control weaknesses (ICW) significantly increases audit report lags, but AS5 does not have any incremental moderating effect on report lags and the ICW relationship. Tests for the firms with company-level and account-specific ICWs demonstrate identical results. Additional analyses show that the learning curve effect takes place rapidly in the early part of the AS5 period and audits continue to remain efficient in terms of reduced report lags in the latter part of the AS5 period relative to the AS2 period. The year-to-year change analyses for the AS5 period further corroborate this result. Overall, our study demonstrates that the top-down, risk-based approach under AS5 makes the audit process more efficient and timelier by decreasing audit report lags.
Data Availability: Data are available from public sources identified in the paper.
The Roles of Organizational Politics and Fairness in the Relationship between Performance Management Systems and Trust
Authors: Lau Chong M. , Scully Glennda 
Published: February 2015

ABSTRACT
Organizational politics is ubiquitous in organizations. Yet to date, no prior research has investigated, in a systematic empirical manner, the mediating role of organizational politics in performance measurement systems. The primary purpose of this research is to investigate if perceptions of organizational politics mediate the relationships between performance measures and employees' trust in their superiors. As organizational politics may also affect employees' perceptions of fairness, a model is used to investigate (1) if performance measures affect organizational politics; (2) if organizational politics, in turn, affects procedural and interpersonal fairness; and (3) if fairness perceptions subsequently affect trust in superiors. Based on a sample of 104 responses, the partial least squares results indicate that organizational politics and fairness perceptions significantly mediate the nonfinancial performance measures and trust relationship. In contrast, the results indicate that the mediating effects of organizational politics and fairness on the relationship between financial performance measures and trust are generally insignificant.
Intensity correlations from linear interactions
Authors: Bina Matteo , Olivares Stefano 
Published: February 2015

AbstractWe address the generation of intensity correlations arising from the interference between two optical states interacting through a beam splitter. We consider both phase insensitive and sensitive states and write the intensity correlations as functions of the mean number of photons and field quadratures of the input states. In particular we consider Fock number states and squeezed states as a paradigm of non-classical states and mixture of coherent states, which can be experimentally accessible. We show that, under certain conditions on the input states, intensity correlations may vanish or turn into anticorrelations.
2014 Update of the Canadian Rheumatology Association/Spondyloarthritis Research Consortium of Canada Treatment Recommendations for the Management of Spondyloarthritis. Part II: Specific Management Recommendations
Authors: Rohekar Sherry , Chan Jon , Tse Shirley M.L. , Haroon Nigil , Chandran Vinod , Bessette Louis , Mosher Dianne , Flanagan Cathy , Keen Kevin J. , Adams Karen , Mallinson Michael , Thorne Carter , Rahman Proton , Gladman Dafna D. , Inman Robert D. 
Published: February 2015

Objective.The Canadian Rheumatology Association (CRA) and the Spondyloarthritis Research Consortium of Canada (SPARCC) have collaborated to update the recommendations for the management of spondyloarthritis (SpA).Methods.A working group was assembled and consisted of the SPARCC executive committee, rheumatologist leaders from SPARCC collaborating sites, Canadian rheumatologists from across the country with an interest in SpA (both academic and community), a rheumatology trainee with an interest in SpA, an epidemiologist/health services researcher, a member of the CRA executive, a member of the CRA therapeutics committee, and a patient representative from the Canadian Spondylitis Association. An extensive review was conducted of literature published from 2007 to 2014 involving the management of SpA. The working group created draft recommendations using multiple rounds of Web-based surveys and an in-person conference.Results.Recommendations for the management of SpA were created. Part II: Specific Management Recommendations addresses management with nonpharmacologic methods, nonsteroidal anti-inflammatories and analgesics, disease-modifying antirheumatic drugs, antibiotics, tumor necrosis factor inhibitors, other biologic agents, and surgery. Also included are 10 modifications for application to juvenile SpA.Conclusion.These recommendations were developed based on current literature and applied to a Canadian healthcare context. It is hoped that implementation of these recommendations will promote best practices in the treatment of SpA.
The Cost of Research: A Survey of Participating Sites in a Nationwide Registry
Authors: Tress Jenna L. , Sherry David D. 
Published: February 2015

Objective.Much attention has been placed upon decreasing costs of clinical research. However, little has been studied about the effects on research completion.Methods.A survey was sent to all registry investigators and coordinators to determine the cost of enrollment in a national registry, whether sites had to supplement using their own funds, and whether the cost affected enrollment.Results.Results indicate that a majority of sites supplemented enrollment with their own funding (88%) and diagnoses requiring a lot of time to enroll were avoided.Conclusion.This survey showed that reimbursement rates were well below the costs of enrollment.
La ponctuation : problématiques linguistiques
Authors: Rault Julien 
Published: February 2015

L’évolution des modes d’appréhension de la ponctuation, au fil des siècles, avec l’intégration progressive de considérations syntaxiques et sémantiques, peut être inscrite dans un mouvement global de grammaticalisation. Ce processus d’encodage a très certainement permis l’émergence d’un questionnement contemporain sur le statut sémiotique des signes de ponctuation : Marques ? Signes ? Signes linguistiques ? Signifié et signifiant ? Si l’on admet, comme le suggère J. Authier-Revuz, qu’il existe une valeur en langue pour chaque signe de ponctuation, celui-ci, considéré dès lors comme une unité du système sémiotique, pourrait véritablement s’inscrire dans la langue écrite (sémiotisation). La proposition portant sur la valeur ou le signifié en langue impose de repenser clairement l’extension de la ponctuation (du mot au texte) et la question des niveaux linguistiques (du graphème à la phrase) ; une telle formulation permettrait sans conteste de clarifier les enjeux, de dépasser le clivage norme/usages pour mieux décrire et interpréter, à partir d’une valeur minimale commune, les signes de ponctuation et la pluralité de leurs interprétations discursives.
Enseigner le système de la ponctuation
Authors: Dufour Marie-Pierre , Chartrand Suzanne-Geneviève 
Published: February 2015

La ponctuation est, pour la linguiste N. Catach (1996), une acquisition fondamentale de la communication humaine. Force est pourtant d’admettre que le domaine, relativement récent dans l’histoire de l’écrit, est difficile à appréhender pour les scripteurs (et lecteurs) non expérimentés que sont des élèves, voire pour les enseignants. Le traitement de la ponctuation dans les outils didactiques pose problème ; ce problème semble prendre racine dans la transposition didactique-même. Or le système de la ponctuation ne peut être compris par les élèves que s’il leur est correctement enseigné, et cet article propose une description de la ponctuation en tant que système. Il ouvre sur des pistes didactiques que nous espérons « salvatrices » pour empêcher la ponctuation, domaine complexe, mais riche, évolutif, offrant au scripteur de multiples possibilités stylistiques, syntaxiques, énonciatives, prosodiques, textuelles... d’être relayée une fois pour toutes au rang de caprice.
Une oralité pas si instinctive ? Les bébés qui ne savent pas téter
Authors: Prieur Régine 
Published: February 2015

Le bébé qui « refuse » le sein est une difficulté dont personne au fond ne comprend l’existence dans un comportement censé être instinctif. Ce « refus » met les mères, bien sûr, mais aussi les équipes soignantes, en difficulté. C’est pourtant une situation clinique que l’auteur expérimente régulièrement. Elle tente ici d’en partager sa compréhension.
La diversification alimentaire de l'enfant : à la recherche du bon sens oublié
Authors: Baudin Marie-Ange 
Published: February 2015

La diversification alimentaire est un moment important dans la vie de l’enfant et de ses parents. Pour s’y retrouver parmi tous les conseils contradictoires reçus, il faut peut-être commencer par se poser les bonnes questions : pourquoi diversifier ? Que veut-on transmettre à son enfant au travers de l’alimentation ? Et aller voir ce qui se fait ailleurs pour relativiser un peu les recommandations françaises. C’est en cela que la pédiatre hongroise Emmi Pikler, et la diversification menée par l’enfant selon Gill Rapley, exportée du Royaume-Uni aux Pays-Bas, nous ouvrent des horizons nouveaux sur la façon d’appréhender l’introduction de la nourriture solide dans l’alimentation des nourrissons. Et s’il suffisait de faire confiance à nos enfants ?
Aedes japonicus japonicus (Diptera: Culicidae) arrives at the most easterly point in North America
Authors: Fielden Miles A. , Chaulk Andrew C. , Bassett Kate , Wiersma Yolanda F. , Erbland Mardon , Whitney Hugh , Chapman Thomas W. 
Published: February 2015

AbstractAedes japonicus japonicus (Theobald) (Diptera: Culicidae), the Asian bush mosquito, is a keen biter linked to the transmission to humans of a variety of diseases. It has moved significantly from its historical Asian distribution, with its arrival in North America first noted in 1998 in New York and New Jersey, United States of America. Here we report the presence of A. j. japonicus within our collections of mosquitoes in the capital city of the easternmost province in Canada: St. John’s, Newfoundland and Labrador, in 2013. This observation provides further evidence of this mosquito’s ability to significantly expand its geographic range, potentially affecting connectivity between subpopulations globally.
Extracorporeal Photopheresis Promotes IL-1β Production
Authors: Yakut Erhan , Jakobs Christopher , Peric Adriana , Michel Gabriela , Baal Nelli , Bein Gregor , Brüne Bernhard , Hornung Veit , Hackstein Holger 
Published: February 2015

Abstract
Extracorporeal photopheresis (ECP) is a widely used clinical cell-based therapy exhibiting efficacy in heterogenous immune-mediated diseases such as cutaneous T cell lymphoma, graft-versus-host disease, and organ allograft rejection. Despite its documented efficacy in cancer immunotherapy, little is known regarding the induction of immunostimulatory mediators by ECP. In this article, we show that ECP promotes marked release of the prototypic immunostimulatory cytokine IL-1β. ECP primes IL-1β production and activates IL-1β maturation and release in the context of caspase-1 activation in monocytes and myeloid dendritic cells. Of interest, IL-1β maturation by ECP was fully intact in murine cells deficient in caspase-1, suggesting the predominance of an inflammasome-independent pathway for ECP-dependent IL-1β maturation. Clinically, patient analysis revealed significantly increased IL-1β production in stimulated leukapheresis concentrates and peripheral blood samples after ECP. Collectively, these results provide evidence for promotion of IL-1β production by ECP and offer new insight into the immunostimulatory capacity of ECP.
A Comparative Analysis of Multiple Sclerosis–Relevant Anti-Inflammatory Properties of Ethyl Pyruvate and Dimethyl Fumarate
Authors: Miljković Djordje , Blaževski Jana , Petković Filip , Djedović Neda , Momčilović Miljana , Stanisavljević Suzana , Jevtić Bojan , Mostarica Stojković Marija , Spasojević Ivan 
Published: February 2015

Abstract
Dimethyl fumarate (DMF), a new drug for multiple sclerosis (MS) treatment, acts against neuroinflammation via mechanisms that are triggered by adduct formation with thiol redox switches. Ethyl pyruvate (EP), an off-the-shelf agent, appears to be a redox analog of DMF, but its immunomodulatory properties have not been put into the context of MS therapy. In this article, we examined and compared the effects of EP and DMF on MS-relevant activity/functions of T cells, macrophages, microglia, and astrocytes. EP efficiently suppressed the release of MS signature cytokines, IFN-γ and IL-17, from human PBMCs. Furthermore, the production of these cytokines was notably decreased in encephalitogenic T cells after in vivo application of EP to rats. Production of two other proinflammatory cytokines, IL-6 and TNF, and NO was suppressed by EP in macrophages and microglia. Reactive oxygen species production in macrophages, microglia activation, and the development of Ag-presenting phenotype in microglia and macrophages were constrained by EP. The release of IL-6 was reduced in astrocytes. Finally, EP inhibited the activation of transcription factor NF-κB in microglia and astrocytes. Most of these effects were also found for DMF, implying that EP and DMF share common targets and mechanisms of action. Importantly, EP had in vivo impact on experimental autoimmune encephalomyelitis, an animal model of MS. Treatment with EP resulted in delay and shortening of the first relapse, and lower clinical scores, whereas the second attack was annihilated. Further studies on the possibility to use EP as an MS therapeutic are warranted.
Cell-Intrinsic Expression of TLR9 in Autoreactive B Cells Constrains BCR/TLR7-Dependent Responses
Authors: Nündel Kerstin , Green Nathaniel M. , Shaffer Arthur L. , Moody Krishna L. , Busto Patricia , Eilat Dan , Miyake Kensuke , Oropallo Michael A. , Cancro Michael P. , Marshak-Rothstein Ann 
Published: February 2015

Abstract
Endosomal TLRs play an important role in systemic autoimmune diseases, such as systemic erythematosus lupus, in which DNA- and RNA-associated autoantigens activate autoreactive B cells through TLR9- and TLR7-dependent pathways. Nevertheless, TLR9-deficient autoimmune-prone mice develop more severe clinical disease, whereas TLR7-deficient and TLR7/9–double deficient autoimmune-prone mice develop less severe disease. To determine whether the regulatory activity of TLR9 is B cell intrinsic, we directly compared the functional properties of autoantigen-activated wild-type, TLR9-deficient, and TLR7-deficient B cells in an experimental system in which proliferation depends on BCR/TLR coengagement. In vitro, TLR9-deficient cells are less dependent on survival factors for a sustained proliferative response than are either wild-type or TLR7-deficient cells. The TLR9-deficient cells also preferentially differentiate toward the plasma cell lineage, as indicated by expression of CD138, sustained expression of IRF4, and other molecular markers of plasma cells. In vivo, autoantigen-activated TLR9-deficient cells give rise to greater numbers of autoantibody-producing cells. Our results identify distinct roles for TLR7 and TLR9 in the differentiation of autoreactive B cells that explain the capacity of TLR9 to limit, as well as TLR7 to promote, the clinical features of systemic erythematosus lupus.
Bortezomib Inhibits Expression of TGF-β1, IL-10, and CXCR4, Resulting in Decreased Survival and Migration of Cutaneous T Cell Lymphoma Cells
Authors: Chang Tzu-Pei , Poltoratsky Vladimir , Vancurova Ivana 
Published: February 2015

Abstract
Increased expression of the immunosuppressive cytokines, TGF-β1 and IL-10, is a hallmark of the advanced stages of cutaneous T cell lymphoma (CTCL), where it has been associated with suppressed immunity, increased susceptibility to infections, and diminished antitumor responses. Yet, little is known about the transcriptional regulation of TGF-β1 and IL-10 in CTCL, and about their function in regulating the CTCL cell responses. In this article, we show that TGF-β1 and IL-10 expression in CTCL cells is regulated by NF-κB and suppressed by bortezomib (BZ), which has shown promising results in the treatment of CTCL. However, although the TGF-β1 expression is IκBα dependent and is regulated by the canonical pathway, the IL-10 expression is IκBα independent, and its inhibition by BZ is associated with increased promoter recruitment of p52 that characterizes the noncanonical pathway. TGF-β1 suppression decreases CTCL cell viability and increases apoptosis, and adding exogenous TGF-β1 increases viability of BZ-treated CTCL cells, indicating TGF-β1 prosurvival function in CTCL cells. In addition, TGF-β1 suppression increases expression of the proinflammatory cytokines IL-8 and IL-17 in CTCL cells, suggesting that TGF-β1 also regulates the IL-8 and IL-17 expression. Importantly, our results demonstrate that BZ inhibits expression of the chemokine receptor CXCR4 in CTCL cells, resulting in their decreased migration, and that the CTCL cell migration is mediated by TGF-β1. These findings provide the first insights into the BZ-regulated TGF-β1 and IL-10 expression in CTCL cells, and indicate that TGF-β1 has a key role in regulating CTCL survival, inflammatory gene expression, and migration.
Influence of a New Software Version of the RTVue-100 Optical Coherence Tomograph on the Detection of Glaucomatous Structural Progression
Authors: Holló Gábor , Naghizadeh Farzaneh 
Published: February 2015

Purpose To compare the current (6.3) and a novel software version (6.12) of the RTVue-100 optical coherence tomograph (RTVue-OCT) for detection of glaucomatous inner macular retinal thickness (ganglion cell complex [GCC]) and retinal nerve fiber layer thickness (RNFLT) progression. Methods In this prospective, observational study, 109 participants (17 healthy controls, 20 patients with ocular hypertension, and 72 patients with glaucoma) were investigated with RTVue-OCT at 6-month intervals (mean follow-up 5 years). One eye per participant was evaluated. Results Long-term measurement variability (residual standard deviation) was significantly lower with software version 6.12 than version 6.3 for all parameters in the total population, the normal controls, and the glaucoma group, respectively (p≤0.0065). The between-software-version difference of residual standard deviation did not correlate with the measured thickness for any parameter. In the glaucoma group, the negative GCC slopes (urn/visit) were significantly (p<0.001) steeper, while the negative RNFLT slopes were either similar or less steep with software version 6.12. Significantly more significant negative GCC parameter slopes were found in the glaucoma group and the total population with version 6.12, while no between-software-version difference was seen for the other groups, and for the RNFLT parameters in all groups. Conclusions The new software version reduces long-term RNFLT and GCC measurement variability, provides steeper GCC progression slopes, and provides more cases of significant GCC progression slopes in glaucoma than the current software version. Since version 6.12 is employed in the recently introduced Widefield RTVue-XR instrument, it may improve detection of glaucomatous progression in clinical practice.