bluuebunny/crossref_metadata_2025_split huggingface dataset:
CENPN contributes to pancreatic carcinoma progression through the MDM2-mediated p53 signaling pathway
Authors: Xu Ming , Tang Jie , Sun Qiong , Meng Jing , Chen Guoyu , Chang Yunli , Yao Yao , Ji Jieru , Luo Hao , Chen Lingling , Lu Minxue , Shi Weiwei 
Published: June 2024

IntroductionWe undertook an in-depth investigation of the data pertaining to pancreatic adenocarcinoma (PAAD) to identify potential targets for the development of precision therapies.Material and methodsThe construction of a protein-protein interaction (PPI) network was based on overlapping differentially expressed genes (DEGs) identified in the GSE16515, GSE32676, and GSE125158 datasets. A subsequent bioinformatic analysis was performed on the interconnected genes within the PPI network, leading to the identification of the central gene, CENPN. In vitro experimentation such as CCK8 and Transwell experiments was employed to elucidate the impact of CENPN expression patterns on PAAD cell proliferation, migration, and invasion. Furthermore, the investigation revealed through comprehensive enrichment analysis that the pivotal signaling pathway associated with CENPN is the p53 signaling pathway.ResultsFollowing a comprehensive bioinformatic analysis of 161 concordant differentially expressed genes (DEGs) across three microarray datasets, CENPN emerged as the central gene under investigation. Overexpression of CENPN in pancreatic adenocarcinoma (PAAD) was associated with unfavorable patient outcomes and heightened sensitivity to four PAAD therapies: gemcitabine, docetaxel, paclitaxel, and sunitinib. Reduced CENPN expression impeded PAAD cell proliferation, migration, and invasion; however, these effects were counteracted upon upregulation of CENPN expression. Additionally, CENPN interacted with MDM2, promoting PAAD progression by targeting the p53 signaling pathway.ConclusionsThe findings of our study substantiate that CENPN is associated with the pathogenesis of PAAD. Consequently, CENPN appears to be a promising candidate for targeted precision therapy in clinical applications.
Internet gaming disorder and the alternative five factor personality model: a study in a Spanish community sample
Authors: Aluja Anton , García Oscar , Balada Ferran , Aymamí Neus , García Luis F. 
Published: June 2024

BackgroundThis study was designed to examine the prevalence and relationships between the Internet gaming disorder (IGD) behaviors, suggested by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and personality traits.Participants and procedureA sample community of 1,548 subjects, 707 men and 841 women, with a mean age of 40.90 and 38.89 years, respectively, was evaluated.ResultsThe results showed that only 7 subjects (0.5%) exceeded the cut-off point of 75 points to be classed as “disordered gamers” proposed by Fuster et al. (2016) in Spain. This study demonstrates the unidimensionality of the IGD-20, so it can be used as an ordinal dimensional measure to study the relationship between IGD symptoms and other related variables such as per-sonality in community samples. A multiple linear regression analysis revealed that up to 8% of the variance of the Internet Gaming Disorder-20 scale (IGD-20), as a dimensional scale, can be explained by low activity, high aggressiveness, introver-sion, non-planning impulsivity, sensation seeking, neuroticism and impulsiveness (attention impulsivity) using the Alterna-tive Five Factor Model (AFFM) of personality and the Barratt Impulsivity Scale (BIS-11).ConclusionsThis study shows that the prevalence of IGD in the Spanish population is similar to that of other Western countries. The unidimensionality of the IGD-20 allows its use in correlational studies to examine the relationship between Internet gam-bling behaviors and personality variables. The implications of these personality profiles are discussed in relation to the psy-chological and clinical mechanisms involved in Internet gaming disorder.
Self-reported health profiles of trauma victims with and without psychiatric histories
Authors: King Alan R. , Kuhn Sara K. , Brezinski Stephanie , Jowkar Michael , Smith Kourtney 
Published: June 2024

BackgroundThis study examined associations between self-reported trauma exposure and physical health status after control of vari-ance associated with psychiatric disturbance. Physical and mental health diagnoses were examined among participants with and without histories of trauma and post-traumatic stress disorder (PTSD).Participants and procedureCollege (n = 2,320) and national (n = 663) respondents were surveyed to identify trauma histories defined using the primary DSM-5 diagnostic criterion for PTSD. Respondents also identified lifetime diagnoses for a range of medical and psychiatric conditions. They were also asked to provide a self-assessment of their own current physical health status using a ten-point scaling metric.ResultsSupport was found for all three hypotheses: (H1) Self-identified trauma was associated with higher prevalence rates for 16 of 18 medical diagnoses; (H2) PTSD diagnoses were associated with higher prevalence rates than trauma alone for 6 of 16 medical conditions; and (H3) Self-reported trauma was associated with higher prevalence rates for 7 of 18 medical condi-tions among respondents who denied psychiatric histories.ConclusionsTrauma exposure both with and without co-occurring psychiatric illness was associated with substantially higher rates of self-reported physical illness. Practitioners and researchers should recognize the potential significance of self-identified trauma and the range of potential biosocial implications that may warrant monitoring.
PEMANFAATAN DATA RUTIN KESEHATAN IBU DAN ANAK UNTUK PERENCANAAN DAN PENGANGGARAN DI UPT PUSKESMAS MEDAN JOHOR
Authors: Ritonga Egril Rehulina 
Published: June 2024

Pada bidang Kesehatan Ibu dan Anak (KIA), penggunaan data rutin berkontribusi terhadap kualitas pelayanan yang dapat mempengaruhi Angka Kematian Ibu dan Angka Kematian Bayi, sehingga penting untuk memahami faktor-faktor yang mempengaruhi pemanfaatan data rutin untuk perbaikan program KIA. Penelitian ini bertujuan untuk mengeksplorasi pemanfaatan data KIA dalam proses perencanaan dan penganggaran program KIA serta faktor-faktor yang perlu ditingkatkan dalam pemanfaatan data KIA salah satu Puskesmas di Kota Medan. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif, yang melibatkan partisipan dari pihak puskesmas dalam bidangnya. Data yang telah dikumpulkan melalui wawancara. Hasil dari penelitian ini menunjukkan bahwa pemanfaatan data KIA untuk perencanaan dan anggaran masih belum optimal dan perlu ditingkatkan. Hal ini disebabkan masih terdapat kendala dalam pemanfaatan data yaitu jaringan internet. Berdasarkan hasil penelitian dapat disimpulkan bahwa dengan data dan informasi yang benar, dapat dibuat sebuah keputusan dan menyusun rencana untuk mengatasi masalah yang ditemukan. Dengan demikian diharapkan dapat meningkatkan ketersediaan data Kesehatan Ibu dan Anak (KIA) yang akurat, lengkap dan tepat waktu yang akhirnya dapat digunakan sebagai salah satu bahan untuk perencanaan, monitoring dan evaluasi program kesehatan pada UPT Puskesmas Medan Johor.
PENGARUH TERAPI MUSIK TERHADAP KECEMASAN IBU HAMIL DI DESA SIGULANG KECAMATAN PADANGSIDIMPUAN TENGGARA
Authors: Tanjung Wiwi wardani , Apripan Rika 
Published: June 2024

Pregnancy is an exciting time and is awaited by mothers and families. All mothers want their pregnancies and deliveries to go safely, smoothly, and normally. However, pregnancy is also a time of excitement and worry. Pregnancy can be a period of crisis in which the mother often feels worried or afraid of the pain and physical dangers that arise during childbirth. This causes bleeding in pregnant women during childbirth. The purpose of this study was to determine the effect of music therapy on reducing anxiety of pregnant women in Sigulang Village, Padangsidimpuan Tenggara District, health. The research used was quasi-experimental research (pseudo-experiment) using the Prettest posttest only research design. The research site is in Sigulang Village, Padangsidimpuan Tenggara District. The study population was 20 pregnant women, the study sample was 20 people. Data analysis using univariate analysis and bivariate analysis. The results showed that there was a decrease in anxiety of pregnant women and the average anxiety score of pregnant women before religious music therapy was 35.33 and after religious music therapy there was a decrease in anxiety with an average of 25.83. The p-value is 0.001, meaning that there is an effect of music therapy on reducing anxiety. The implication of this study is that the provision of religious music therapy can reduce anxiety in pregnant women when facing childbirth.
Hubungan Riwayat ANC, Riwayat IMD, Dan Dukungan Sosial Terhadap Pelaksanaan ASI Eksklusif di Kota Binjai
Authors: Ismail Ilvira Ulpa 
Published: June 2024

ABSTRAK

Cakupan ASI eksklusif di Sumatera Utara pada Tahun 2021 tercatat hanya 57,88 % , dan hanya 15,75% cakupan ASI eksklusif di kota Binjai, angka ini jauh dari target nasional di Indonesia yaitu 80%. Tujuan penelitian ini dilakukan untuk melihat hubungan riwayat ANC, riwayat IMD dan dukungan sosial terhadap pelaksanaan ASI eksklusif di kota Binjai. Metode Penelitian ini menggunakan desain analitik observational dengan pendekatan cross sectional, dengan populasi penelitian ibu yang memiliki bayi usia > 6 bulan-12 bulan di wilayah kerja Dinas Kesehatan Kota Binjai mulai dari bulan mei sampai juni 2022. Adapun pengambilan sampel penelitian menggunakan Proportional Sampling dengan teknik anccidental terhadap 283 responden. Pengumpulan menggunakan uji univariat, uji bivariat dan multivariat berupa regresi logistik.
Hasil penelitian ini didapat ada hubungan riwayat ANC dengan pelaksanan ASI eksklusif p=0,043, ada hubungan riwayat IMD dengan pelaksanaan ASI eksklusif p=0,000, ada hubungan dukungan sosial dengan pelaksanaan ASI eksklusif p=0,049, dan IMD merupakan variabel dominan terhadap pelaksanaan ASI eksklusif di kota Binjai dengan nilai OR 1,866. Kesimpulan dari penelitian ini IMD merupakan variabel dominan terhadap pelaksanaan ASI eksklusif di kota Binjai, artinya ibu yang melakukan IMD memiliki peluang 1,866 kali lebih besar melakukan pemberian ASI eksklusif di kota Binjai.

Kata kunci : ANC, ASI Eksklusif, IMD
Hubungan Genetik Terhadap Kejadian Diabetes Mellitus Pada Lansia Di Desa Rimba Soping Kota Padangsidimpuan
Authors: Hasibuan Ahmad Safii , Sahriani Henny 
Published: June 2024

ABSTRAK
Diabetes melitus (DM) merupakan salah satu diantara penyakit tidak menular yang masih menjadi permasalahan di Indonesia. Penyakit diabetes melitus menurut WHO paling sering menyerang pada orang lanjut usia ≥60 tahun. faktor yang dapat memicu terjadinya DM adalah Genetik. Penyakit Diabetes Mellitus (DM) menempati urutan ke delapan untuk urutan penyakit tidak menular. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara genetic terhadap kejadian Diabetes Mellitus pada lansia Di Desa Rimba Soping. Penelitian ini merupakan penelitian Kuantitatif dengan Desain Penelitian cross sectional dan Pengambilan sampel menggunakan simple random sampling. Dengan jumlah responden dalam penelitian ini sebanyak 60 orang. Pengumpulan data dengan menggunakan kuesioner. Hasil penelitian, ada hubungan antara genetik (p>(0,023)) terhadap kejadian DM pada lansia. Saran peneliti bagi lansia mempersiapkan diri ketika petugas kesehatan memberikan penyuluhan tentang faktor-faktor pemicu Diabetes Melitus untuk tetap mendengarkan, memahami, mengaplikasikan, menganalisis, mensintesis dan mengevaluasinya supaya tidak terjadi komplikasi.
Kata kunci : Diabetes Mellitus, Genetik

Abstract
Diabetes mellitus (DM) is one of these diseases infectious disease which is still a problem in Indonesia. According to WHO, diabetes mellitus most often attacks elderly people aged ≥60 years. Factors that can trigger DM are genetics. Diabetes Mellitus (DM) ranks eighth in the ranking of non-communicable diseases. The aim of this research is to determine the relationship between genetics and the incidence of Diabetes Mellitus in the elderly in Rimba Soping Village. This research is a quantitative study with a cross sectional research design and sampling using simple random sampling. The number of respondents in this study was 60 people. Data collection using questionnaires. The results of the research showed that there was a relationship between genetics (p>(0.023)) and the incidence of DM in the elderly. The researcher's advice for the elderly is to prepare themselves when health workers provide education about the factors that trigger Diabetes Mellitus to continue listening, understanding, applying, analyzing, synthesizing and evaluating it so that complications do not occur..

Keywords : Diabetes Mellitus, Genetics
Transport of the Hunga volcanic aerosols inferred from Himawari-8/9 limb measurements
Authors: Prata Fred 
Published: June 2024

Abstract. The Hunga volcano (21.545° S, 178.393° E; also known as Hunga Tonga-Hunga Ha′apai) erupted on 15 January 2022, producing copious amounts of aerosols that reached high into the stratosphere, exceeding 30 km and settling into layers a few kilometres deep between 22 and 28 km. The Advanced Himawari Imager (AHI) on board the geostationary Himawari-8/9 platform at 140.7° E was able to monitor the eruption at 10 min intervals and 0.25 to 4 km2 spatial resolution within 16 spectral channels ranging from visible to infrared wavelengths and over a latitude–longitude field of view of ∼ ±75°. Here a new use of these data is proposed where the limb region of the field of view is exploited to detect aerosol layers extending vertically into the atmosphere. The analyses provide vertical profiles of scattered visible light and are compared to CALIOP space lidar measurements. Hunga aerosols are detected using the ratio of near-infrared reflectances at 1.61 and 2.25 µmm in the western limb from 22 January and in the eastern limb from 31 January 2022 up until the present time (December 2023). Between January and April 2022, the average zonal velocity is estimated to be ∼ −25 m s−1 (westwards) and the meridional velocity to be ∼ 0.2 m s−1 (northwards). The latitudinal spread is characterized by a gradual northerly movement of the main layer situated between 22 and 28 km in the first 60 d, and stagnation or slight southerly spread thereafter. There is a shallow maximum of the lower stratospheric aerosol between 10 and 20° S, and the aerosol loading during 2023 is elevated compared with the 3 months prior to the eruption. The Southern Hemisphere (0–30° S) tropical lower stratospheric aerosol e-folding time is estimated to be ∼ 12 months, but the decay is not uniform and has high variability. The current methodology does not provide quantitative estimates of the amount or type of aerosol, but based on the spectral properties of water and ice clouds the analysis suggests there is a strong liquid water content in the aerosol layers.
Justice, Equity and Good-Conscience: Analysis of the Case Law in Pakistan
Authors: Batool Usmat 
Published: June 2024

The concepts of equity, justice, and good conscience have guided areas of the legal system not covered by statute law or personal laws since the early East India Company days. For instance, in circumstances where they were not otherwise expressly addressed, judges were to base their rulings on equity, justice, and good conscience, according to the regulations from 1781 and 1793. The idea was replicated from one regulation to another and from one statute to another. According to Derrett, this approach was initially applied by the Royal Charter of August 9, 1683, which considered other legal sources as "just" norms that applied to the case's facts in addition to English law. By the end of the nineteenth century, British Indian Courts preferred to apply English Law as residual law first, then equity, justice, and good conscience. Courts in Pakistan occasionally use this Common Law formula to fill in the blanks. This paper examines the history of equity in common law and analyse briefly the case law of Pakistan.
قاعدة عودة الضمير وأثرها في ترجيح أقوال المفسرين
Authors: إدريس صلاح الدين عوض محمد 
Published: June 2024

يهدف هذا البحث إلى الكشف عن العلاقة الوثيقة بين قواعد اللغة، وقواعد التفسير، وكيف تم استخدام قواعد النحو خاصة قاعدة: "عودة الضمير" في تفسير النصوص القرآنية، والموازنة والمقارنة والترجيح بعد تعذر الجمع بين أقوال المفسرين. قام منهج البحث في هذه الدراسة على المنهج الاستقرائي الذي حرص على تطبيق قاعدة : " عودة الضمير" بجانب قواعد تفسيرية أخرى ذات صلة بهذه القاعدة النحوية مثل قاعدة العموم والسياق، وغيرهما من القواعد المشتركة بين قواعد النحو و قواعد التفسير. وقد خلص البحث إلى أن الاختلاف بين العلماء في عودة الضمير يوسع من دلالات النص القرآني وغالب الاختلاف بين المفسرين فيه يعود إلى اختلاف التنوع والتعدد لا اختلاف التناقض والتضاد. صحيح قد توجد بعض التفسيرات التي لا تخلو من التكلف والتمحُّل في تأويل النصوص بسبب التقيد بشروط وضوابط قاعدة" عودة الضمير" تنتهي بالمفسرين إلى اختلاف التناقض والتضاد ولكنها قليلة من السهل الترجيح بينها.
СҮТ БЕЛОГЫ ПЕПТИДТЕРІНІҢ АНТИМИКРОБТЫҚ БЕЛСЕНДІЛІГІ
Authors: NARMURATOVA M.Kh. , USMANOVA Z.U. , GHAFOORI E.M. , АSKAR А.Zh. , ZHUNISBEK А.М. , NARMURATOVA Zh B. 
Published: June 2024

This article describes the antimicrobial activity of milk proteins and peptides formed from them. Today, the global problem of modern medicine and the entire humanity is the resistance of pathogenic microorganisms to antibiotics. Widespread and uncontrolled use of antimicrobial drugs, as well as non-compliance with treatment regimens, contributes to the proliferation of this phenomenon. The emergence of antibiotic-resistant types of pathogenic microorganisms, which contribute to the development of incurable and fatal diseases, is especially dangerous. In this regard, the search and development of new groups of drugs that can affect the activity and development of pathogenic microorganisms is relevant. Antimicrobial peptides are one of the potential groups of compounds with the desired set of effects against pathogenic microorganisms. Antimicrobial peptides are a family of small peptides that occur in nature and play an important role in the body's innate immune system. In addition, antimicrobial peptides can be produced from various protein sources such as milk by enzymatic hydrolysis or fermentation with microorganisms. Antimicrobial peptides are widely used in the food and pharmaceutical industries.
Бұл мақалада, сүт белоктары және олардан түзілелін пептидтердің антимикробтық белсенділігі туралы сипатталған. Қазіргі уақытта заманауи медицинаның және бүкіл адамзаттың жаһандық мәселесі патогенді микроорганизмдер антибиотиктерге төзімділігі болып табылады. Бұл құбылыстың кең таралуына патогенді микроорганизмдерге қарсы препараттарды кеңінен және бақылаусыз қолдану, емдеу режимдерін бұзу ықпал етеді. Әсіресе, емделмейтін және өлімге әкелетін аурулардың дамуына ықпал ететін патогенді микроорганизмдердің антибиотиктерге төзімді түрлерінің пайда болуы қауіпті. Осыған байланысты патогенді микроорганизмдердің тіршілік әрекеті мен дамуына әсер ете алатын дәрілік заттардың жаңа топтарын іздеу және дамыту өзекті болып табылады. Патогенді микроорганизмдерге қарсы әсерлердің қажетті жиынтығы бар қосылыстардың потенциалды топтарының бірі микробқа қарсы пептидтер (антимикробтық пептидтер). Негізінен, антимикробтық пептидтер - бұл табиғатта кездесетін және организмнің туа пайда болған иммундық жүйесінде маңызды рөл атқарады. Бұдан басқа, антимикробтық пептидтер сүт сияқты әртүрлі белок көздерінен ферменттік гидролиз немесе микроорганизмдер көмегімен ашыту арқылы өндірілуі мүмкін. Антимикробтық пептидтер тағам және фармацевтика өнеркәсібінде кеңінен қолданылады.
La redacción científica en inglés como lengua extranjera
Authors: Sánchez Alvarado Alber Francisco 
Published: June 2024

Este trabajo de investigación explora la compleja interacción entre la memoria de trabajo (MT) y el dominio de la escritura en inglés como lengua extranjera, particularmente para los hablantes de inglés de L2 de español. Postula que estos individuos se enfrentan a desafíos cognitivos en la MT debido a la complejidad inherente de la escritura en lenguas extranjeras (L2). El documento aboga por la adopción de un enfoque de aprendizaje profundo durante las primeras etapas de la adquisición del inglés para hacer frente a estos desafíos de manera efectiva. Haciendo hincapié en la importancia de adquirir de manera óptima las habilidades fundamentales, como escuchar, hablar y leer, recomienda que los escritores de L2 cultiven concienzudamente estas habilidades para mejorar sus habilidades de escritura. Este compromiso proactivo con las habilidades fundamentales, junto con las estrategias para tomar notas a mano, se propone como un medio estratégico para que los escritores de L2 superen las demandas cognitivas asociadas con el dominio de la escritura en inglés.
Carbon Dioxide and Nitrate Electrocatalytic C-N Coupling for Sustainable Production of Urea
Authors: Jia Litao , Li Fanghua 
Published: June 2024

Review
Carbon Dioxide and Nitrate Electrocatalytic C-N Coupling for Sustainable Production of Urea

Litao Jia, and Fanghua Li *

School of Environment, Harbin Institute of Technology, Harbin 150090, China
* Correspondence: fanghuahope01@hit.edu.cn
Received: 15 December 2023; Revised: 17 January 2024; Accepted: 19 February 2024; Published: 5 March 2024

Abstract:
The electrocatalytic co-reduction of carbon dioxide (CO2) and nitrate (NO3−) for urea synthesis under environmental conditions offers a promising solution for achieving sustainable environmental management. Besides, electrochemical urea synthesis is an alternative approach for cleaner production of urea compared to the conventional urea industrial production process with high energy consumption and pollution. However, lower urea yield, lower selectivity and unclear C-N coupling reaction mechanism are still the main challenges to its large-scale application. In this review, we focus on accurate and reliable detection methods and evaluation criteria for urea products, recent progress on CO2 and NO3− electrocatalytic co-reduction synthesis of urea, rational design of high-performance electrocatalysts, and C-N coupling reaction mechanism of urea electrochemical synthesis under atmospheric conditions. This review could contribute to the development of electrochemical urea synthesis via effective remediation of CO2 and NO3−.