bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular Postoperative Changes After Facial Flap Repairs: An Opportunity for Early Intervention
Authors: Berman Hannah S. , Awe Olufolakemi , Heckman Michael G. , White Launia J. , Carrasquillo Osward Y. , Barbosa Naiara , Merritt Bradley , Degesys Catherine A. 
Published: July 2024

BACKGROUND
Flap repair provides unique advantages in facial reconstruction but still carries the potential for undesirable postoperative cosmetic changes.

OBJECTIVE
The aims of this study were to describe postoperative vascular outcomes of patients undergoing flap repairs after Mohs micrographic surgery on facial tumors and to assess associations of baseline characteristics with outcomes.

MATERIALS AND METHODS
In this study, 7 dermatologists and 1 physician assistant in dermatology assessed preoperative and postoperative photographs of 57 patients who underwent facial Mohs micrographic surgery, evaluating vascular and pigment outcomes and number of telangiectasias.

RESULTS
There was a significant difference in number of telangiectasias according to body location (p = .002), where the number of telangiectasias was highest for nose surgery.

CONCLUSION
These data suggest that nasal flap repairs are associated with increased postoperative vascular changes. This highlights an opportunity for improved preoperative patient counseling and possible early laser treatment after nasal Mohs micrographic surgery.
GIFTS: Geriatric Intensive Functional Therapy Sessions—for the older trauma patient
Authors: Wintz Diane , Schaffer Kathryn B. , Hites Jennifer J. , Wybourn Christopher , Bui Eric H. , Langness Simone , Hamel Michelle , Wright Kelly , Frey John R. 
Published: July 2024

BACKGROUND
Considering resources for comprehensive geriatric care, it would be beneficial for geriatric trauma patients (GTPs) and medical patients to be comanaged in one program focusing on ancillary therapeutics (AT): physical therapy, occupational therapy, speech language pathology, respiratory therapy, and sleep wake hygiene. This pilot study describes outcomes of GTPs in a hospital-wide program focused on geriatric-specific AT.

METHODS
Geriatric trauma patients and geriatric patients were screened by program coordinator for enrollment at one Level II trauma center from August 2021 to December 2022. Enrolled patients (EPs) were admitted to trauma or medicine floors and received repetitive AT with attention to sleep wake hygiene throughout hospitalization and compared with similar nonenrolled patients (NEPs). Excluded patients had any of the following: indication of geriatric syndrome with a fatigue, resistance, ambulation, illness, and loss of weight (FRAIL) score of 5, no frailty with a FRAIL score of 0, comfort focused plans, or arrived from skilled care. Retrospective chart review of demographics and outcomes was completed for both EPs and NEPs.

RESULTS
A total of 224 EPs (28 trauma [TR]) were compared with 574 NEPs (148 TR). Enrolled patients showed shorter length of stay (mean, 3.8 vs. 6.1; p = 0.0001), less delirium (3.1% vs. 9.6%, p = 0.00222), less time to ambulation (13 hours vs. 39 hours, p = 0.0005), and higher likelihood to discharge home (56% vs. 27%, p < 0.0001) as compared with NEPs. The median FRAIL score was 3 for both groups. Enrolled medical patients ambulated the soonest at 11 average hours, compared with 23 hours for enrolled trauma patients and 39 hours for NEPs. There were zero delirium events among enrolled trauma patients; 25% was found among nonenrolled trauma patients (p = 0.00288).

CONCLUSION
Despite a small trauma cohort, results support feasibility to include GTPs in hospital-wide programs with geriatric-specific AT. Mobility and cognitive strategies may improve opportunities to avoid delirium, decrease length of stay, and influence more frequent disposition to home.

LEVEL OF EVIDENCE
Therapeutic/Care Management; Level III.
ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+uptake and oxidative metabolism
Authors: Dematteis Giulia , Tapella Laura , Casali Claudio , Talmon Maria , Tonelli Elisa , Reano Simone , Ariotti Adele , Pessolano Emanuela , Malecka Justyna , Chrostek Gabriela , Kulkovienė Gabrielė , Umbrasas Danielius , Distasi Carla , Grilli Mariagrazia , Ladds Graham , Filigheddu Nicoletta , Fresu Luigia G , Mikoshiba Katsuhiko , Matute Carlos , Ramos-Gonzalez Paula , Jekabsone Aiste , Calì Tito , Brini Marisa , Biggiogera Marco , Cavaliere Fabio , Miggiano Riccardo , Genazzani Armando A , Lim Dmitry 
Published: July 2024

ABSTRACTIP3receptor (IP3R)-mediated Ca2+transfer at the mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) drives mitochondrial Ca2+uptake and oxidative metabolism and is linked to different pathologies, including Parkinson’s disease (PD). The dependence of Ca2+transfer efficiency on the ER-mitochondria distance remains unexplored. Employing molecular rulers that stabilize ER-mitochondrial distances at 5 nm resolution, and using genetically-encoded Ca2+indicators targeting the ER lumen and the sub-mitochondrial compartments, we now show that a distance of ∼20 nm is optimal for Ca2+transfer and mitochondrial oxidative metabolism due to enrichment of IP3R at MERCS. In human iPSC-derived astrocytes from PD patients, 20 nm MERCS were specifically reduced which correlated with a reduction of mitochondrial Ca2+uptake. Our work determines with precision the optimal distance for Ca2+flux between ER and mitochondria and suggests a new paradigm for fine control over mitochondrial function.
Loss of H3K9 trimethylation leads to premature aging
Authors: Mrabti Calida , Yang Na , Desdín-Micó Gabriela , Alonso-Calleja Alejandro , Vílchez-Acosta Alba , Pico Sara , Parras Alberto , Piao Yulan , Schoenfeldt Lucas , Luo Siyuan , Haghani Amin , Brooke Robert , Maza María del Carmen , Branchina Clémence , Yacoub Maroun Céline , von Meyenn Ferdinand , Naveiras Olaia , Horvath Steve , Sen Payel , Ocampo Alejandro 
Published: July 2024

SUMMARYAging is the major risk factor for most human diseases and represents a major socio-economical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic dysregulation has been proposed as a key driver of the aging process. Modifications in transcriptional networks and chromatin structure might be central to age-related functional decline. A prevalent feature described during aging is the overall reduction in heterochromatin, specifically marked by the loss of repressive histone modification, Histone 3 lysine 9 trimethylation (H3K9me3). However, the role of H3K9me3 in aging, especially in mammals, remains unclear. Here we show using a novel mouse strain, (TKOc), carrying a triple knockout of three methyltransferases responsible for H3K9me3 deposition, that the inducible loss of H3K9me3 in adulthood results in premature aging. TKOc mice exhibit reduced lifespan, lower body weight, increased frailty index, multi-organ degeneration, transcriptional changes with significant upregulation of transposable elements, and accelerated epigenetic age. Our data strongly supports the concept that the loss of epigenetic information directly drives the aging process. These findings reveal the importance of epigenetic regulation in aging and suggest that interventions targeting epigenetic modifications could potentially slow down or reverse age-related decline. Understanding the molecular mechanisms underlying the process of aging will be crucial for developing novel therapeutic strategies that can delay the onset of age-associated diseases and preserve human health at old age specially in rapidly aging societies.
DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci
Authors: Liu Yuzhen , McGann Christopher D. , Krebs Mary , Perkins Thomas A. , Fields Rose , Camplisson Conor K. , Nwizugbo David Z. , Hsu Chris , Avanessian Shayan C. , Tsue Ashley F. , Kania Evan E. , Shechner David M. , Beliveau Brian J. , Schweppe Devin K. 
Published: July 2024

AbstractThe accuracy of crucial nuclear processes such as transcription, replication, and repair, depends on the local composition of chromatin and the regulatory proteins that reside there. Understanding these DNA-protein interactions at the level of specific genomic loci has remained challenging due to technical limitations. Here, we introduce a method termed “DNA O-MAP”, which uses programmable peroxidase-conjugated oligonucleotide probes to biotinylate nearby proteins. We show that DNA O-MAP can be coupled with sample multiplexed quantitative proteomics and next-generation sequencing to quantify DNA-protein and DNA-DNA interactions at specific genomic loci.
Could Chinese cardiovascular chronic conditions patients gain benefits from pharmaceutical services? A multilevel meta-analysis
Authors: Deng Zhijie , Chen Fanglu , Peng Shunshun , Gui Lin , Huang Yangjin , Chen Jing , Wei Anhua , Ding Yufeng 
Published: July 2024

AbstractBackgroundThe value of pharmaceutical services for Chinese patients with cardiovascular chronic conditions was not recognized.AimTo investigate the comprehensive value of pharmaceutical services in China and find factors influencing patient benefits.Design and settingThis was a systematic review with multilevel meta-analysis of 183 randomized control trials focusing on the benefits of pharmaceutical services for patients with cardiovascular chronic conditions in China.MethodsEnglish databases (PubMed, EMBASE, the Cochrane Library) and Chinese databases (China National Knowledge Infrastructure, WanFang database) were searched from database inception to March 27, 2023 for studies focusing on the comparation of benefits between pharmaceutical services and usual care.ResultsOur analysis of 187 studies involving 23,895 patients demonstrated significant benefits of pharmaceutical services, particularly in reducing readmission (OR: 0.32; 95%CI: 0.2 to 0.52; I2=50.12%), mitigating ADR (OR: 0.28; 95%CI: 0.24 to 0.33; I2=18.07%), and improving patient adherence. However, no benefit was observed in terms of mortality rate and the cost of hospitalization and medication and the risk of bias was generally existed among the included studies.ConclusionsThis study highlights the significant benefits of pharmaceutical services for clinical outcomes and adherence among Chinese patients with cardiovascular chronic conditions. However, the benefits in terms of economic outcomes remain unclear. The influence of population-specific factors, such as disease and age, underscores the need for context-specific and disease- tailored studies to provide precise evidence regarding the advantages of pharmaceutical services. And our findings provide some new ideas for the subsequent research and design, standard formulation and policy implementation.How this fits inPrevious assessments showed clinical benefits of pharmaceutical services but were unclear about other benefits and didn’t consider patient characteristics or contexts. There is no standardized system for pharmaceutical services in China. Our meta-analysis found clear clinical benefits for patients with cardiovascular chronic conditions and showed that age negatively impacts adherence, and medication costs vary by disease type. This study is the first to analyze comprehensive benefits for Chinese patients, highlighting the importance of considering patient characteristics in pharmaceutical services.
REalist Synthesis Of non-pharmacologicaL interVEntions for antipsychotic-induced weight gain (RESOLVE) in people living with severe mental illness
Authors: MacPhee Maura , Howe Jo , Habib Hafsah , Piwowarczyk Emilia , Wong Geoff , Ahern Amy , Birdi Gurkiran , Higgs Suzanne , Oduola Sheri , Kenny Alex , Walsh Annabel , Upthegrove Rachel , Allen Katherine , Carlish Max , Lovell Justine , Maidment Ian 
Published: July 2024

AbstractIntroductionAntipsychotic medications are used to treat individuals with severe mental illness (SMI), but are associated with rapid weight gain and several physical and mental risk factors. Early, proactive weight management is necessary to pre-empt these risk factors. The aim was to understand and explain how, why, for whom, and in what contexts non-pharmacological interventions can help to manage antipsychotic-induced weight gain.MethodsRealist review to identify contextual factors and underlying mechanisms associated with effective, non-pharmacological weight management interventions for adults > 18 years old. Practitioners and lived experience stakeholders were integral.Results74 documents used to construct programme theory and 12 testable context-mechanism-outcome configurations. People with SMI benefit from support when navigating interventions aimed at managing the weight gain. From a practitioner perspective, a good therapeutic relationship is important in helping people with SMI navigate early diagnosis and treatment options and facilitating exploring any pre-existing issues. Interventions that are flexible and tailored to the needs of individuals, ideally starting early in a person’s recovery journey are likely to yield better results. Additional sources of support include family, friends and peers with lived experience who can help individuals transition to autonomous goal-setting. The review findings also emphasise the significant effect of stigma/dual stigma on individuals with SMI and weight gain.ConclusionsSuccessful interventions are collaborative, flexible and underpinned by early and comprehensive assessment with use of appropriate behaviour change approaches. The therapeutic relationship is key with a de-stigmatising approach required. A realist evaluation with primary data is currently underway.Practitioner PointsIndividuals with severe mental illness on antipsychotic medications are at high risk for rapid weight gain and associated adverse mental and physical outcomes.Early comprehensive assessment by knowledgeable, respectful practitioners promotes therapeutic relationship development and identification of individuals’ specific risk factors and support, such as pre-existing disordered eating behaviours and the presence of family/carer and peer support.Case management or care coordination needs to be strengthened to ensure individuals’ access to consistent primary and secondary services, as well as community-based services.
AP-1 Mediates Cellular Adaptation and Memory Formation During Therapy Resistance
Authors: Li Jingxin , Ravindran Pavithran T. , O’Farrell Aoife , Busch Gianna T. , Boe Ryan H. , Niu Zijian , Woo Sean , Dunagin Margaret C. , Jain Naveen , Goyal Yogesh , Sarma Kavitha , Herlyn Meenhard , Raj Arjun 
Published: July 2024

AbstractCellular responses to environmental stimuli are typically thought to be governed by genetically encoded programs. We demonstrate that melanoma cells can form and maintain cellular memories during the acquisition of therapy resistance that exhibit characteristics of cellular learning and are dependent on the transcription factor AP-1. We show that cells exposed to a low dose of therapy adapt to become resistant to a high dose, demonstrating that resistance was not purely selective. The application of therapy itself results in the encoding of transient gene expression into cellular memory and that this encoding occurs for both transiently induced and probabilistically arising expression. Chromatin accessibility showed concomitant persistence. A two-color AP-1 reporter system showed that these memories are encoded incis, constituting an example of activatingcisepigenetics. Our findings establish the formation and maintenance of cellular memories as a critical aspect of gene regulation during the development of therapy resistance.
Improved tests for the origin of allometric scaling across tree architectures
Authors: Chmurzynski Adam , Brummer Alexander Byers , Savage Van , Shenkin Alexander , Malhi Yadvinder , Martin-Ducup Olivier , Zieminska Kasia , Barbier Nicolas , Enquist Brian J. 
Published: July 2024

AbstractThe scaling of organismal metabolic rates with body size is one of the most prominent empirical patterns in biology. For over a century, the nature and causes of metabolic scaling have been the subject of much focus and debate. West, Brown, and Enquist (WBE) proposed a general model for the origin of metabolic scaling from branching vascular networks. However, recent empirical tests of WBE vascular scaling predictions in plants and animals have reported deviations caused by variability in network geometry. After clarifying the core assumptions of the WBE model, we revisit the methods and conclusions of recent tests conducted in trees, finding support for key WBE predictions in woody plant architecture. To do this, we apply an approach that better captures: i) network branching self-similarity and ii) leaf area as a proxy of plant metabolic capacity. The WBE model also predicts curvature in metabolic scaling in smaller organisms, and we introduce a novel method that accounts for curvature in plant branching geometry. Together, these advances allow more direct measurements of metabolic scaling than previous work, and we apply them to a dataset of diverse laser-scanned tree architectures. Analyses reveal the predicted interspecific ¾ metabolic scaling across tree crowns, with intraspecific variation within individual tree crowns. Scaling variability is consistent with WBE predictions for curvature from asymptotic growth and underlying variation in branching geometry. We conclude that linking fine-scale branching variation to metabolic scaling allometries remains a challenge, while our results support the foundational hypotheses of the WBE model.Author summaryTrees survive in a variety of habitats and lifestyles across Earth. They are also characterized by a stunning array of sizes and shapes that make trees objects of vast cultural, economic, and ecological importance. At the same time, the need to link vascular plant function with traits and environment is more pressing than ever. Size (body mass) is fundamentally linked to plant functioning within ecosystems through allometric relationships. Allometric relationships emerge from the geometry of branch networks in trees, which are increasingly well-characterized with remote-sensing data. We use a dataset of laser-scanned tree crowns to test allometric predictions that link size to key traits, particularly metabolic capacity, understood as total leaf area. Our results indicate that i) scanning technology can provide accurate assessments of branch allometry with proper data preparation, and ii) studying branch allometries provides an organizing framework for interpreting natural variation in tree architecture.
Expectation modulates learning emotional words: Evidence from a hierarchical Bayesian model
Authors: Zhang Weiwei , Li Yingyu , Zhou Chuan , Li Baike , Schwieter John W. , Liu Huanhuan , Liu Meng 
Published: July 2024

AbstractIn language acquisition, individuals learn the emotional value of words through external feedback. Previous studies have used emotional words as experimental materials to explore the cognitive mechanism underlying emotional language processing, but have failed to recognize that languages are acquired in a changing environment. To this end, this study aims to combine reinforcement learning with emotional word learning, using a probabilistic reversal learning task to explore how individuals acquire the valence of emotional words in a dynamically changing environment. Our computational modeling on both behavioral and event-related potential (ERP) data revealed that individuals’ expectations can modulate the learning speed and temporal processing of emotional words, demonstrating a clear negative bias. Specifically, as the expected value increases, individuals respond faster and exhibit higher amplitudes for negative emotional words. These findings shed light on the neural mechanisms of emotional word learning in a volatile environment, highlighting the crucial role of expectations in this process and the preference for processing negative information.
Effect of team-member exchange on team innovative work behavior: a chained double mediation model
Authors: Dar Nasib , Kundi Yasir Mansoor , Hamid Zeeshan 
Published: July 2024

PurposeThis study examines the direct influence of team-member exchange (TMX) on team innovative work behavior (IWB) and the mediating roles of team knowledge sharing and team job crafting.Design/methodology/approachTo test our research model, we collected multilevel, multisource, and multi-wave data from 284 employees and 74 teams in Pakistan.FindingsTMX positively relates to team IWB directly and indirectly via serial mediation of team knowledge sharing and team job crafting.Originality/valueThis is the first study to investigate how TMX promotes team IWB through team knowledge sharing and team job crafting.
ESG in investor profiling: what are we talking about?
Authors: Lippi Andrea , Poli Federica 
Published: July 2024

PurposeInspired by the groundbreaking novel European regulations on financial investors’ profiling (MiFID II regulation and the ESMA 2022 Guidelines), this paper aims to establish which distinctive socio-demographic traits distinguish investors who declare a generalized interest in all three environmental (E), social (S), and governance (G) pillars and investors who express interest in just one individual pillar or a combination of two pillars.Design/methodology/approachBased on a unique dataset of 190 real-world retail investors, this paper aims to create a profile of three types of investor: those whose interest lies in just the environmental pillar, those interested in a combination of the environmental and social pillars, and those interested in all three E, S, and G pillars jointly. Moreover, we try to ascertain whether it is possible to observe statistically significant differences between the different types of investors.FindingsThe results obtained indicate that it is possible to profile investors who are environmentally-oriented and investors who are ESG-oriented. Notably, levels of financial literacy do not influence investor ESG attitudes.Practical implicationsThe results obtained may have multifaceted implications for financial advisors, the banking and financial institution industry, and marketing strategists, as well as for further research.Originality/valueThe originality of this paper derives from the responses used in the analysis, which were collected from a sample of real-world retail investors who completed a mandatory MiFID-questionnaire, validated by the Italian Securities and Markets Supervisory Authority. Our paper thus represents a bridge between a theoretical approach and real-world practice.