bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum D-dimer level in women with polycystic ovary syndrome
Authors: Hossan S , Morshed MS , Banu H , Hasanat MA 
Published: June 2024

AbstractBackgroundWomen with polycystic ovarian syndrome (PCOS) have hyperandrogenemia and insulin resistance, which predispose them to prothrombotic conditions. D-dimer is a global marker of hemostatic dysfunction that has a contentious relationship with PCOS.ObjectiveTo assess the association of D-dimer with PCOS and its manifestationsMethodsThis case-control study enrolled 44 women with PCOS based on the International Evidence-based Guideline, 2018, and an equal number of matched healthy controls by convenient sampling. After obtaining informed consent, participants’ clinical data was taken, and fasting blood was drawn to measure glucose, lipid profile, hormones, and D-dimer. D-dimer was analyzed by latex immunofluorescence assay.ResultsThe D-dimer levels and status were statistically similar between the study groups [PCOS vs. control: 0.11 (0.10-0.17) vs. 0.13 (0.10-0.22), median (IQR), p= 0.673]. D-dimer levels did not vary according to the different characteristics of women with PCOS (p>0.05). D-dimer levels had no significant correlations with various clinical and biochemical characteristics among women with PCOS (p>0.05).ConclusionD-dimer has no significant association with PCOS or its manifestations.
Complementary value of molecular, phenotypic and functional aging biomarkers in dementia prediction
Authors: Engvig Andreas , Kalleberg Karl Trygve , Westlye Lars T. , Leonardsen Esten Høyland ,   Alzheimer’s Disease Neuroimaging Initiative
Published: June 2024

AbstractDNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of stages of cognitive impairment and future risk of dementia using the ADNI database. Of several MA algorithms, DunedinPACE had the strongest association with neuropsychological tests and was included alongside BA and FI in predictive analyses.The pairwise correlations between age- and sex-adjusted measures for MA (aDundedinPACE), brain age (aBA), and frailty (aFI) were low (all <0.15). In a prediction model including age, sex, and aFI, we achieved an area under the curve (AUC) of 0.95 for differentiating cognitively normal controls (CN) from dementia patients in a held-out test set. The best models for CN vs. mild cognitive impairment (MCI) and MCI vs. dementia contained age, sex, aFI and aBA as predictors, and achieved out-of-sample AUCs of 0.82 and 0.83 respectively. When combined with clinical biomarkers (apolipoprotein E ε4 allele count, memory, executive function), a model including aBA and aFI predicted 5-year dementia risk among MCI patients with an out-of-sample AUC of 0.83. aDunedinPACE did not improve the predictions. FI had a stronger adverse effect on prognosis in males, while BA’s impact was greater in females.Our findings highlight complementary value of BA and FI in dementia prediction. The results support a multidimensional view of dementia, including an intertwined relationship between the biomarkers, sex, and prognosis. The tested MA’s limited contribution suggests caution in their use for individual risk assessment of dementia.
Determining the optimal hematoma volume-based thresholds for surgical and medical strategies in basal ganglia hemorrhage
Authors: Chaisawasthomrong Chonnawee , Boongird Atthaporn 
Published: June 2024

AbstractBackgroundThe indication for surgical intervention in spontaneous intracerebral hemorrhage remains controversial, particularly regarding the benefits of early hematoma drainage via open craniotomy. This study aimed to identify the maximum hematoma volume suitable for conservative treatment and the volume that represents an absolute indication for surgery in patients with basal ganglia hemorrhage.MethodsA retrospective analysis was performed on the medical records of patients admitted for basal ganglia hemorrhage from 2019 to 2021. The data encompassed personal history, general information and diagnostic imaging records, particularly CT brain scans from the initial ER visit, were examined to ascertain hematoma volume. The comparison focused on evaluating the outcomes of patients who received medical treatment compared to those who underwent surgical intervention, mainly considering various hematoma volumes, and was conducted using multivariate logistic analysis.ResultsIn a study of 387 cases of basal ganglia hemorrhage, analysis of medical treatment alone across various hematoma volumes revealed that the group with volumes between 10 and 39.9 ml showed no significant difference in mortality compared to the group with volumes less than 10 ml. The Receiver Operating Characteristics (ROC) curve identified a 45.3 ml cutoff for survival prediction with medical treatment alone. Notably, patients in the subgroup undergoing surgical intervention with a hematoma volume less than 30 ml exhibited significantly higher mortality than those who did not undergo surgery. Conversely, there was a pronounced and statistically significant trend toward increased survival in the group with a hematoma volume of at least 60 ml.ConclusionsThe application of medical treatment alone is suitable for hematoma volumes ranging from 0 to 45.3 ml, whereas volumes of 60 ml or more serve as a clear indication for surgical intervention in patients with basal ganglia hemorrhage.
Insulin-AKT1-YBX1 Regulation of ANGPTL8 Promote Lipogenesis in Obstructive Sleep Apnea-Associated Dyslipidemia
Authors: Liu Yuenan , Yuan Haolin , Wang Anzhao , Wang Shengming , Xu Xu , Hu Junhui , Shen Jinhong , Hu Yiming , Li Xinyi , Li Niannian , Gao Zhenfei , Zhang Xiaoxu , Zhang Xiaoman , Liu Yupu , Xu Huajun , Yi Hongliang , Guan Jian , Li Zhiqiang , Zhao Yongxu , Yin Shankai , Liu Feng 
Published: June 2024

AbstractDyslipidemia is a hallmark of obstructive sleep apnea (OSA)-induced metabolic syndrome, yet the mechanisms remain poorly understood. We conducted a genome-wide association study on lipid traits in the OSA cohorts, identifying the SNP rs3745683 inANGPTL8, significantly associated with reductions in multiple lipid traits. ANGPTL8, an essential lipogenic hormone and potential therapeutic target for metabolic syndrome, showed elevated expression in OSA patients compared to healthy controls, strongly correlated with increased insulin levels. Notably,ANGPTL8expression can be upregulated by insulin stimulation, indicating it as an insulin-responsive hormone regulating dyslipidemia in OSA. Mechanistically, SNP rs3745683 attenuatedANGPTL8transcription by inhibiting its binding to transcription factor YBX1. Insulin prompted AKT1 to phosphorylate YBX1 at Ser102, facilitating YBX1’s nuclear translocation and subsequent regulation ofANGPTL8expression and lipid synthesis. Specific knockdown of YBX1 in mouse liver confirmed its necessity forANGPTL8expression and hepatic lipid synthesis in vivo. Our findings highlightANGPTL8as a critical regulator of dyslipidemia in OSA patients, offering a promising therapeutic avenue for managing metabolic syndrome in OSA.
Oxytocin receptor function regulates neural signatures of pair bonding and fidelity in the nucleus accumbens
Authors: Long Kimberly L. P. , Hoglen Nerissa E. G. , Keip Alex J. , Klinkel Robert M. , See DéJenaé L. , Maa Joseph , Wong Jenna C. , Sherman Michael , Manoli Devanand S. 
Published: June 2024

AbstractThe formation of enduring relationships dramatically influences future behavior, promoting affiliation between familiar individuals. How such attachments are encoded to elicit and reinforce specific social behaviors in distinct ethological contexts remains unknown. Signaling via the oxytocin receptor (Oxtr) in the nucleus accumbens (NAc) facilitates social reward as well as pair bond formation between mates in socially monogamous prairie voles1–9. How Oxtr function influences activity in the NAc during pair bonding to promote affiliative behavior with partners and rejection of other potential mates has not been determined. Using longitudinalin vivofiber photometry in wild-type prairie voles and those lacking Oxtr, we demonstrate that Oxtr function sex-specifically regulates pair bonding behaviors and associated activity in the NAc. Oxtr function influences prosocial behavior in females in a state-dependent manner. Females lacking Oxtr demonstrate reduced prosocial behaviors and lower activity in the NAc during initial chemosensory investigation of novel males. Upon pair bonding, affiliative behavior with partners and neural activity in the NAc during these interactions increase, but these changes do not require Oxtr function. Conversely, males lacking Oxtr display increased prosocial investigation of novel females. Using the altered patterns of behavior and activity in the NAc of males lacking Oxtr during their first interactions with a female, we can predict their future preference for a partner or stranger days later. These results demonstrate that Oxtr function sex-specifically influences the early development of pair bonds by modulating prosociality and the neural processing of sensory cues and social interactions with novel individuals, unmasking underlying sex differences in the neural pathways regulating the formation of long-term relationships.
Three-point energy correlators in hadronic Higgs boson decays
Authors: Yang Tong-Zhi , Zhang Xiaoyuan 
Published: June 2024

We present the analytic calculation of the leading-order three-point energy correlator (EEEC) in hadronic Higgs decays, including both the gluon-initiated channel H→gg+X and quark-initiated channel H→qq¯+X. The phase-space integration is evaluated directly using Mandelstam variables sij=(pi+pj)2, and the appearing square roots can be rationalized by either conformal ratios or celestial coordinate variables. Throughout the calculation, we observe the same transcendental function space as in N=4 super–Yang-Mills theory and e+e−→hadrons. Different infrared limits are also explored using the full analytic result, offering the fixed-order data for EEEC factorization and resummation. Given its nontrivial shape dependence, the EEEC presents an excellent opportunity to explore the dynamics of gluon jets originating from the H→gg decay channel at future lepton colliders.

Published by the American Physical Society
2024
Higgs to
bb¯
from vector boson fusion for high-scale physics
Authors: Han Tao , Leung Sze Ching Iris , Low Matthew 
Published: June 2024

Vector boson fusion is arguably the most direct collider probe of electroweak symmetry breaking. Typically, the signature includes two forward/backward jets with low transverse momenta with a scale that is set by the mass of the vector boson. For this reason, an upper cut is used when searching for vector boson fusion processes in the Standard Model. Alternatively, the upper cut on the forward jets can be removed and the high-momentum exchange region of vector boson fusion can be studied. This phase space region has sensitivity to new physics via higher dimensional operators and form factors. In this work, we study the high-momentum region of the vector boson fusion channel where the Higgs decays to bb¯. We show that, depending on the form of new physics, the limits on the new physics scale range from 0.5 to 1.8 TeV.

Published by the American Physical Society
2024
Lie-algebraic Kähler sigma models with U(1) isotropy
Authors: Sheu Chao-Hsiang , Shifman Mikhail 
Published: June 2024

We discuss various questions that emerge in connection with the Lie-algebraic deformation of the CP1 sigma model in two dimensions. First, we supersymmetrize the original model endowing it with the minimal N=(0,2) and extended N=(2,2) supersymmetries. Then we derive the general hypercurrent anomaly in both cases. In the latter case this anomaly is one-loop but is somewhat different from the standard expressions one can find in the literature because the target manifold is nonsymmetric. We also show how to introduce the twisted masses and the θ term, and study the Bogomol’nyi–Prasad–Sommerfield equation for instantons, in particular the value of the topological charge. Then we demonstrate that the second loop in the β function of the Lie-algebraic sigma model is due to an infrared effect. To this end we use a regularization. We also conjecture that the above statement is valid for higher loops too, similar to the parallel phenomenon in four-dimensional N=1 super-Yang-Mills. In the second part of the paper we develop a special dimensional reduction—namely, starting from the two-dimensional Lie-algebraic model we arrive at a quasi-exactly solvable quantum-mechanical problem of the Lamé type.

Published by the American Physical Society
2024
Online academic group sentiment analyses informing workplace online group sentiment
Authors: Roberts Robin , Denney Valerie , Marion Jim W. 
Published: June 2024

Purpose
Researchers have investigated best practices for forming groups capable of completing projects cohesively for years. Online group formation has increased in recent years, peaking scientific interest in the sentiment that characterizes group cohesion from the point when the group is established to the stage where specific outcomes are produced. This research contributes to understanding online group dynamics by analyzing the sentiment of university students completing multiple nine-week group course projects with implications for workplaces.

Design/methodology/approach
Over eight nine-week terms, sentiment analyses were conducted on students' online reflection assignments, targeting their views on group interactions during group project completion. The assignment's context was to assess individual sentiment about the group experience that could build group sentiment implications for workplaces. Adult students from diverse academic and industry disciplines at a single university were participants. Four group models were considered possible drivers of student sentiment about their group experiences.

Findings
Punctuated Equilibrium, a classic group model, defined influences like remote distances and external obligations steering student sentiment outcomes. Instructors' active facilitation of group formation and development motivated students’ positive sentiments. Findings are akin to online organizational groups’ attempts to manage remote work and other responsibilities.

Originality/value
This study reinforced the importance of leveraging online students' collective sentiment to inform group dynamics in professional settings. Few studies have focused on the latter directly and exclusively. The results highlighted the sentiment kinship of online academic and organizational groups, validating the focused investigation of this study.
Mentoring students in higher education for reflection and development of employability competences: a pre-test post-test design
Authors: Nuis Wendy , van der Baan Niels Andreas , Beausaert Simon 
Published: June 2024

PurposeGiven the dynamic and fast-evolving labour market, developing students’ employability competences has become of utmost importance for higher education institutions. The ability to reflect is essential to develop these competences, as it helps students to identify their learning needs and make plans for further development. However, reflective abilities are not easy to acquire and students need guidance to help them reflect. Therefore, mentoring is often used as an instructional approach to stimulate students to reflect. Empirical evidence on the relation between mentoring and employability competences is scarce, and the mediating role of reflection especially has rarely been researched. Consequently, the present study aims to investigate this mediating relationship, employing a pre-test post-test design.Design/methodology/approachQuestionnaire data were collected from students before and after participation in four similar 1-year mentoring programmes in higher education within the Netherlands and Belgium (n = 160).FindingsThe path analysis demonstrated that, first, trust and availability, autonomy support and empathy were significantly related to students’ employability competences. Secondly, autonomy support and similarity were significantly related to students’ critical reflection. Thirdly, critical reflection was significantly related to students’ employability competences. Last, reflection partially mediated the relationship between mentoring (autonomy support and similarity) and employability.Originality/valueTo the best of the authors’ knowledge, this study is the first attempt to demonstrate that mentoring programmes in higher education enable students to reflect and, in turn, develop their employability competences. Furthermore, it provides mentoring programme directors and mentors with concrete guidelines for developing students’ reflection and employability competences.
Secure data communication in WSN using Prairie Indica optimization
Authors: Amune Amruta Chandrakant , Pande Himangi 
Published: June 2024

PurposeSecurity is the major issue that motivates multiple scholars to discover security solutions apart from the advantages of wireless sensor networks (WSN) such as strong compatibility, flexible communication and low cost. However, there exist a few challenges, such as the complexity of choosing the expected cluster, communication overhead, routing selection and the energy level that affects the entire communication. The ultimate aim of the research is to secure data communication in WSN using prairie indica optimization.Design/methodology/approachInitially, the network simulator sets up clusters of sensor nodes. The simulator then selects the Cluster Head and optimizes routing using an advanced Prairie Indica Optimization algorithm to find the most efficient communication paths. Sensor nodes collect data, which is securely transmitted to the base station. By applying prairie indica optimization to WSNs, optimize key aspects of data communication, including secure routing and encryption, to protect sensitive information from potential threats.FindingsThe Prairie Indica Optimization, as proposed, achieves impressive results for networks comprising 50 nodes, with delay, energy and throughput values of 77.39 ms, 21.68 J and 22.59 bps. In the case of 100-node networks, the achieved values are 80.95 ms, 27.74 J and 22.03 bps, significantly surpassing the performance of current techniques. These outcomes underscore the substantial improvements brought about by the Prairie Indica Optimization in enhancing WSN data communication.Originality/valueIn this research, the Prairie Indica Optimization is designed to enhance the security of data communication within WSN.
Value and quality investing strategy in Indian stock market
Authors: Kaur Satinder , Seth Sidharath , Singh Jaspal 
Published: June 2024

PurposeThe objective of the study is to shed light on the notion of quality investing in the Indian stock market. The study also attempts to combine the value and quality metrics to test their ability to generate a higher risk-adjusted return.Design/methodology/approachThe paper employs asset pricing models to examine the excess risk-adjusted returns and panel regression model (random estimates) to determine the price of quality in the cross-section of Bombay Stock Exchange (BSE) listed stocks from 2003 to 2020.FindingsThe results indicate that the quality-only strategy failed to produce substantial risk-adjusted returns in the Indian stock market. The returns to long/short hedging strategy quality-minus-junk (QMJ) are significantly positive with the majority of the returns attributable to the short leg of the stock portfolio. The findings further discovered that the explanatory effect of quality on prices is limited. In particular, a strategy that combines value and quality investing generated positive and significant alphas as well as a higher Sharpe ratio.Practical implicationsThe study provides investors and portfolio managers with valuable insights for navigating undervalued high-quality equities in the Indian stock market.Originality/valueThis is the first research of its kind to examine the performance of quality (Q score indicator) combined with value investing in the Indian stock market. As majority of research have concentrated on developed economies, this study offers out-of-sample evidence to validate the strategy’s success in an emerging market.
Relationship between medication safety‐related processes and medication use in residential aged care facilities
Authors: Poudel Ramesh Sharma , Williams Kylie A. , Pont Lisa G. 
Published: June 2024

AbstractObjectiveTo explore the association between the implementation of medication safety‐related processes measured with the Medication Safety Self‐Assessment for Long‐Term Care (MSSA‐LTC) tool and medication use in residential aged care facilities (RACFs).MethodsA descriptive cross‐sectional study was conducted in Australian RACFs. Data on facility characteristics, aggregated medication use at the facility level for selected medications commonly associated with a high risk of harm and the MSSA‐LTC were completed by clinical pharmacists providing clinical pharmacy services. The Spearman's correlation test was used to evaluate the association between the MSSA‐LTC score and medication use. A scatter plot between the MSSA‐LTC score and medication use data was generated, and a linear trend line was plotted using the least squares method.ResultsData were collected from 31 RACFs servicing 2986 residents. Most medication safety‐related processes were implemented in Australian RACFs. A higher facility MSSA‐LTC score was associated with a lower proportion of residents with polypharmacy (r = −.48, p = .01) and one or more benzodiazepines (r = −.41, p = .03). In addition, a negative linear trend was observed between the MSSA‐LTC score and the average number of medications per resident, the proportion of residents with one or more anticonvulsants and the proportion of residents using one or more opioid analgesics.ConclusionsThis study indicates that implementing medication safety‐related processes may improve medication use in RACFs.
Photovoltaic, wireless wide‐field epiretinal prosthesis to treat retinitis pigmentosa
Authors: Schulz André , Knoll Thorsten , Jaeger Tino , Le Harzic Ronan , Stracke Frank , Wien Sascha L. , Olsommer Yves , Meiser Ina , Wagner Sylvia , Rammensee Michael , Kurz Oliver , Klesy Stephan , Sermeus Loic , Julich‐Haertel Henrike , Schweitzer Yanick , Januschowski Kai , Velten Thomas , Szurman Peter 
Published: June 2024

AbstractPurposeTo develop and evaluate a photovoltaic, wireless wide‐field epiretinal prosthesis for the treatment of retinitis pigmentosa.MethodsA mosaic array of thinned silicon‐based photodiodes with integrated thin‐film stimulation electrodes was fabricated with a flexible polyimide substrate film to form a film‐based miniaturized electronic system with wireless optical power and signal transmission and integrated electrostimulation. Manufactured implants were characterized with respect to their optoelectronic performance and biocompatibility following DIN EN ISO 10993.ResultsA 14 mm diameter prosthesis containing 1276 pixels with a maximum sensitivity at a near infrared wavelength of 905 nm and maximized stimulation current density 30–50 μm below the electrodes was developed for direct activation of retinal ganglion cells during epiretinal stimulation. Fabricated prostheses demonstrated mucosal tolerance and the preservation of both metabolic activity, proliferation and membrane integrity of human fibroblasts as well as the retinal functions of bovine retinas. Illumination of the prosthesis, which was placed epiretinally on an isolated perfused bovine retina, with infrared light resulted in electrophysiological recordings reminiscent of an a‐wave (hyperpolarization) and b‐wave (depolarization).ConclusionsA photovoltaic, wireless wide‐field epiretinal prosthesis for the treatment of retinitis pigmentosa using near infrared light for signal transmission was designed, manufactured and its biocompatibility and functionality demonstrated in vitro and ex vivo.