bluuebunny/crossref_metadata_2025_split huggingface dataset:
DISAPPOINTMENT AVERSION PREMIUM PRINCIPLE
Authors: Cheung Ka Chun , Chong Wing Fung , Elliott Robert , Yam Sheung Chi Phillip 
Published: July 2015

AbstractIn recent years, the determination of premium principle under various non-expected utility frameworks has become popular, such as the pioneer works by Tsanakas and Desli (2003) and Kaluszka and Krzeszowiec (2012). We here revisit the problem under another prevalent behavioral economic theory, namely the Disappointment Aversion (DA) Theory proposed by Gul (1991). In this article, we define and study the properties of theDA premium principle, which builds on the equivalent utility premium principle. We derive various properties of this premium principle, such as non-negative and no unjustified risk loading, translation invariance, monotonicity, convexity, positive (non-)homogeneity, independent (non-)additivity, comonotonic (non-)additivity and monotonicity with respect to the extent of disappointment. A generalized Arrow–Pratt approximation is also established. Explicit representations of the premium principle are obtained for linear and exponential utilities, and they reveal that the premium principle proposed echoes the capital reserve regulatory requirement in practice.
Surgical Site Infection After Primary Hip and Knee Arthroplasty: A Cohort Study Using a Hospital Database
Authors: Grammatico-Guillon Leslie , Baron Sabine , Rosset Philippe , Gaborit Christophe , Bernard Louis , Rusch Emmanuel , Astagneau Pascal 
Published: July 2015

BACKGROUNDHip or knee arthroplasty infection (HKAI) leads to heavy medical consequences even if rare.OBJECTIVETo assess the routine use of a hospital discharge detection algorithm of prosthetic joint infection as a novel additional tool for surveillance.METHODSA historic 5-year cohort study was built using a hospital database of people undergoing a first hip or knee arthroplasty in 1 French region (2.5 million inhabitants, 39 private and public hospitals): 32,678 patients with arthroplasty code plus corresponding prosthetic material code were tagged. HKAI occurrence was then tracked in the follow-up on the basis of a previously validated algorithm using International Statistical Classification of Disease, Tenth Revision, codes as well as the surgical procedures coded. HKAI density incidence was estimated during the follow-up (up to 4 years after surgery); risk factors were analyzed using Cox regression.RESULTSA total of 604 HKAI patients were identified: 1-year HKAI incidence was1.31%, and density incidence was 2.2/100 person-years in hip and 2.5/100 person-years in knee. HKAI occurred within the first 30 days after surgery for 30% but more than 1 year after replacement for 29%. Patients aged 75 years or older, male, or having liver diseases, alcohol abuse, or ulcer sore had higher risk of infection. The inpatient case fatality in HKAI patients was 11.4%.CONCLUSIONSThe hospital database method used to measure occurrence and risk factors of prosthetic joint infection helped to survey HKAI and could optimize healthcare delivery.Infect Control Hosp Epidemiol 2015;36(10):1198–1207
The myocardial and coronary histopathology and pathogenesis of hypoplastic left heart syndrome
Authors: Cole Charles R. , Eghtesady Pirooz 
Published: July 2015

AbstractHypoplastic left heart syndrome has the greatest mortality rate among all CHDs and without palliation is uniformly fatal. Despite noble efforts, the aetiology of this syndrome is unknown and a cure remains elusive. The genetic and anatomic heterogeneity of hypoplastic left heart syndrome supports a rethinking of old hypotheses and warrants further investigation into the histological and vascular variations recognised with this syndrome. In an effort to elucidate the pathogenesis of hypoplastic left heart syndrome, this review will focus on its unique myocardial and coronary pathology as well as evaluate the association of hypoplastic left heart syndrome with the endocardial fibroelastosis reaction.
Measuring Cognition in Bipolar Disorder with Psychosis Using the MATRICS Consensus Cognitive Battery
Authors: Sperry Sarah H. , O’Connor Lauren K. , Öngür Dost , Cohen Bruce M. , Keshavan Matcheri S. , Lewandowski Kathryn E. 
Published: July 2015

AbstractGiven the substantial overlap in cognitive dysfunction between bipolar disorder (BD) and schizophrenia (SZ), we examined the utility of the MATRICS Consensus Cognitive Battery (MCCB)—developed for use in SZ—for the measurement of cognition in patients with BD with psychosis (BDP) and its association with community functioning. The MCCB, Multnomah Community Ability Scale, and measures of clinical symptoms were administered to participants with BDP (n=56), SZ (n=37), and healthy controls (HC) (n=57). Groups were compared on clinical and cognitive measures; linear regressions examined associations between MCCB and community functioning. BDP and SZ groups performed significantly worse than HC on most neurocognitive domains; BDP and HC did not differ on Social Cognition. Patients with BDP performed better than patients with SZ on most cognitive measures, although groups only differed on social cognition, working memory, verbal memory, and the composite after controlling for clinical variables. MCCB was not associated with community functioning. The MCCB is an appropriate measure of neurocognition in BDP but does not appear to capture social cognitive deficits in this population. The addition of appropriate social cognitive measures is recommended. (JINS, 2015, 21, 468–472)
Causative role of left aIPS in coding shared goals during human–avatar complementary joint actions
Authors: Sacheli Lucia M. , Candidi Matteo , Era Vanessa , Aglioti Salvatore M. 
Published: July 2015

AbstractSuccessful motor interactions require agents to anticipate what a partner is doing in order to predictively adjust their own movements. Although the neural underpinnings of the ability to predict others’ action goals have been well explored during passive action observation, no study has yet clarified any critical neural substrate supporting interpersonal coordination during active, non-imitative (complementary) interactions. Here, we combine non-invasive inhibitory brain stimulation (continuous Theta Burst Stimulation) with a novel human–avatar interaction task to investigate a causal role for higher-order motor cortical regions in supporting the ability to predict and adapt to others’ actions. We demonstrate that inhibition of left anterior intraparietal sulcus (aIPS), but not ventral premotor cortex, selectively impaired individuals’ performance during complementary interactions. Thus, in addition to coding observed and executed action goals, aIPS is crucial in coding ‘shared goals’, that is, integrating predictions about one’s and others’ complementary actions.
Novel drug target identification for the treatment of dementia using multi-relational association mining
Authors: Nguyen Thanh-Phuong , Priami Corrado , Caberlotto Laura 
Published: July 2015

AbstractDementia is a neurodegenerative condition of the brain in which there is a progressive and permanent loss of cognitive and mental performance. Despite the fact that the number of people with dementia worldwide is steadily increasing and regardless of the advances in the molecular characterization of the disease, current medical treatments for dementia are purely symptomatic and hardly effective. We present a novel multi-relational association mining method that integrates the huge amount of scientific data accumulated in recent years to predict potential novel targets for innovative therapeutic treatment of dementia. Owing to the ability of processing large volumes of heterogeneous data, our method achieves a high performance and predicts numerous drug targets including several serine threonine kinase and a G-protein coupled receptor. The predicted drug targets are mainly functionally related to metabolism, cell surface receptor signaling pathways, immune response, apoptosis and long-term memory. Among the highly represented kinase family and among the G-protein coupled receptors, DLG4 (PSD-95) and the bradikynin receptor 2 are highlighted also for their proposed role in memory and cognition, as described in previous studies. These novel putative targets hold promises for the development of novel therapeutic approaches for the treatment of dementia.
High efficiency silicon solar cell based on asymmetric nanowire
Authors: Ko Myung-Dong , Rim Taiuk , Kim Kihyun , Meyyappan M. , Baek Chang-Ki 
Published: July 2015

AbstractImproving the efficiency of solar cells through novel materials and devices is critical to realize the full potential of solar energy to meet the growing worldwide energy demands. We present here a highly efficient radial p-n junction silicon solar cell using an asymmetric nanowire structure with a shorter bottom core diameter than at the top. A maximum short circuit current density of 27.5 mA/cm2 and an efficiency of 7.53% were realized without anti-reflection coating. Changing the silicon nanowire (SiNW) structure from conventional symmetric to asymmetric nature improves the efficiency due to increased short circuit current density. From numerical simulation and measurement of the optical characteristics, the total reflection on the sidewalls is seen to increase the light trapping path and charge carrier generation in the radial junction of the asymmetric SiNW, yielding high external quantum efficiency and short circuit current density. The proposed asymmetric structure has great potential to effectively improve the efficiency of the SiNW solar cells.
Pathogenic diversity amongst serotype C VGIII and VGIV Cryptococcus gattii isolates
Authors: Rodrigues Jéssica , Fonseca Fernanda L. , Schneider Rafael O. , Godinho Rodrigo M. da C. , Firacative Carolina , Maszewska Krystyna , Meyer Wieland , Schrank Augusto , Staats Charley , Kmetzsch Livia , Vainstein Marilene H. , Rodrigues Marcio L. 
Published: July 2015

AbstractCryptococcus gattii is one of the causative agents of human cryptococcosis. Highly virulent strains of serotype B C. gattii have been studied in detail, but little information is available on the pathogenic properties of serotype C isolates. In this study, we analyzed pathogenic determinants in three serotype C C. gattii isolates (106.97, ATCC 24066 and WM 779). Isolate ATCC 24066 (molecular type VGIII) differed from isolates WM 779 and 106.97 (both VGIV) in capsule dimensions, expression of CAP genes, chitooligomer distribution and induction of host chitinase activity. Isolate WM 779 was more efficient than the others in producing pigments and all three isolates had distinct patterns of reactivity with antibodies to glucuronoxylomannan. This great phenotypic diversity reflected in differential pathogenicity. VGIV isolates WM 779 and 106.97 were similar in their ability to cause lethality and produced higher pulmonary fungal burden in a murine model of cryptococcosis, while isolate ATCC 24066 (VGIII) was unable to reach the brain and caused reduced lethality in intranasally infected mice. These results demonstrate a high diversity in the pathogenic potential of isolates of C. gattii belonging to the molecular types VGIII and VGIV.
Aerial projection of three-dimensional motion pictures by electro-holography and parabolic mirrors
Authors: Kakue Takashi , Nishitsuji Takashi , Kawashima Tetsuya , Suzuki Keisuke , Shimobaba Tomoyoshi , Ito Tomoyoshi 
Published: July 2015

AbstractWe demonstrate an aerial projection system for reconstructing 3D motion pictures based on holography. The system consists of an optical source, a spatial light modulator corresponding to a display and two parabolic mirrors. The spatial light modulator displays holograms calculated by computer and can reconstruct holographic motion pictures near the surface of the modulator. The two parabolic mirrors can project floating 3D images of the motion pictures formed by the spatial light modulator without mechanical scanning or rotating. In this demonstration, we used a phase-modulation-type spatial light modulator. The number of pixels and the pixel pitch of the modulator were 1,080 × 1,920 and 8.0 μm × 8.0 μm, respectively. The diameter, the height and the focal length of each parabolic mirror were 288 mm, 55 mm and 100 mm, respectively. We succeeded in aerially projecting 3D motion pictures of size ~2.5 mm3 by this system constructed by the modulator and mirrors. In addition, by applying a fast computational algorithm for holograms, we achieved hologram calculations at ~12 ms per hologram with 4 CPU cores.
RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1
Authors: Biondini Marco , Duclos Guillaume , Meyer-Schaller Nathalie , Silberzan Pascal , Camonis Jacques , Parrini Maria Carla 
Published: July 2015

AbstractRalA and RalB proteins are key mediators of oncogenic Ras signaling in human oncogenesis. Herein we investigated the mechanistic contribution of Ral proteins to invasion of lung cancer A549 cells after induction of epithelial-mesenchymal transition (EMT) with TGFβ. We show that TGFβ-induced EMT promotes dissemination of A549 cells in a 2/3D assay, independently of proteolysis, by activating the Rho/ROCK pathway which generates actomyosin-dependent contractility forces that actively remodel the extracellular matrix, as assessed by Traction Force microscopy. RalB, but not RalA, is required for matrix deformation and cell dissemination acting via the RhoGEF GEF-H1, which associates with the Exocyst complex, a major Ral effector. Indeed, uncoupling of the Exocyst subunit Sec5 from GEF-H1 impairs RhoA activation, generation of traction forces and cell dissemination. These results provide a novel molecular mechanism underlying the control of cell invasion by RalB via a cross-talk with the Rho pathway.
Parity-dependent State Engineering and Tomography in the ultrastrong coupling regime
Authors: Felicetti S. , Douce T. , Romero G. , Milman P. , Solano E. 
Published: July 2015

AbstractReaching the strong coupling regime of light-matter interaction has led to an impressive development in fundamental quantum physics and applications to quantum information processing. Latests advances in different quantum technologies, like superconducting circuits or semiconductor quantum wells, show that the ultrastrong coupling regime (USC) can also be achieved, where novel physical phenomena and potential computational benefits have been predicted. Nevertheless, the lack of effective decoupling mechanism in this regime has so far hindered control and measurement processes. Here, we propose a method based on parity symmetry conservation that allows for the generation and reconstruction of arbitrary states in the ultrastrong coupling regime of light-matter interactions. Our protocol requires minimal external resources by making use of the coupling between the USC system and an ancillary two-level quantum system.
Rapid and Sensitive Isothermal Detection of Nucleic-acid Sequence by Multiple Cross Displacement Amplification
Authors: Wang Yi , Wang Yan , Ma Ai-Jing , Li Dong-Xun , Luo Li-Juan , Liu Dong-Xin , Jin Dong , Liu Kai , Ye Chang-Yun 
Published: July 2015

AbstractWe have devised a novel amplification strategy based on isothermal strand-displacement polymerization reaction, which was termed multiple cross displacement amplification (MCDA). The approach employed a set of ten specially designed primers spanning ten distinct regions of target sequence and was preceded at a constant temperature (61–65 °C). At the assay temperature, the double-stranded DNAs were at dynamic reaction environment of primer-template hybrid, thus the high concentration of primers annealed to the template strands without a denaturing step to initiate the synthesis. For the subsequent isothermal amplification step, a series of primer binding and extension events yielded several single-stranded DNAs and single-stranded single stem-loop DNA structures. Then, these DNA products enabled the strand-displacement reaction to enter into the exponential amplification. Three mainstream methods, including colorimetric indicators, agarose gel electrophoresis and real-time turbidity, were selected for monitoring the MCDA reaction. Moreover, the practical application of the MCDA assay was successfully evaluated by detecting the target pathogen nucleic acid in pork samples, which offered advantages on quick results, modest equipment requirements, easiness in operation and high specificity and sensitivity. Here we expounded the basic MCDA mechanism and also provided details on an alternative (Single-MCDA assay, S-MCDA) to MCDA technique.
Small-signal modulation characteristics of a polariton laser
Authors: Zunaid Baten Md , Frost Thomas , Iorsh Ivan , Deshpande Saniya , Kavokin Alexey , Bhattacharya Pallab 
Published: July 2015

AbstractUse of large bandgap materials together with electrical injection makes the polariton laser an attractive low-power coherent light source for medical and biomedical applications or short distance plastic fiber communication at short wavelengths (violet and ultra-violet), where a conventional laser is difficult to realize. The dynamic properties of a polariton laser have not been investigated experimentally. We have measured, for the first time, the small signal modulation characteristics of a GaN-based electrically pumped polariton laser operating at room temperature. A maximum −3 dB modulation bandwidth of 1.18 GHz is measured. The experimental results have been analyzed with a theoretical model based on the Boltzmann kinetic equations and the agreement is very good. We have also investigated frequency chirping during such modulation. Gain compression phenomenon in a polariton laser is interpreted and a value is obtained for the gain compression factor.
TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT
Authors: Zhuang Junlong , Lu Qun , Shen Bing , Huang Xiaojing , Shen Lan , Zheng Xi , Huang Ruimin , Yan Jun , Guo Hongqian 
Published: July 2015

AbstractUrinary bladder cancer (UBC) patients at muscle invasive stage have poor clinical outcome, due to high propensity for metastasis. Cancer-associated fibroblasts (CAFs), one of the principal constituents of the tumor stroma, play an important role in tumor development. However, it is unclear whether CAFs from UBC induce cell invasion and which signaling pathway is involved. Herein, we found that conditional medium from UBC CAFs (CAF-CM) enhanced the invasion of UBC cells. CAF-CM induced the epithelial-mesenchymal transition (EMT) by regulating expression levels of EMT-associated markers in UBC cells. Higher concentration of TGFβ1 in CAF-CM, comparing with the CM from adjacent normal fibroblast, led to phosphorylation of Smad2 in UBC cells. Additionally, inhibition of TGFβ1 signaling decreased the EMT-associated gene expression and cancer cell invasion. Interestingly, a long non-coding RNA, ZEB2NAT, was demonstrated to be essential for this TGFβ1-dependent process. ZEB2NAT depletion reversed CAF-CM-induced EMT and invasion of cancer cells, as well as reduced the ZEB2 protein level. Consistently, TGFβ1 mRNA expression is positively correlated with ZEB2NAT transcript and ZEB2 protein levels in human bladder cancer specimens. Our data revealed a novel mechanism that CAFs induces EMT and invasion of human UBC cells through the TGFβ1-ZEB2NAT-ZEB2 axis.
Preferential enhancement of laser-driven carbon ion acceleration from optimized nanostructured surfaces
Authors: Dalui Malay , Wang W.-M. , Trivikram T. Madhu , Sarkar Subhrangsu , Tata Sheroy , Jha J. , Ayyub P. , Sheng Z. M. , Krishnamurthy M. 
Published: July 2015

AbstractHigh-intensity ultrashort laser pulses focused on metal targets readily generate hot dense plasmas which accelerate ions efficiently and can pave way to compact table-top accelerators. Laser-driven ion acceleration studies predominantly focus on protons, which experience the maximum acceleration owing to their highest charge-to-mass ratio. The possibility of tailoring such schemes for the preferential acceleration of a particular ion species is very much desired but has hardly been explored. Here, we present an experimental demonstration of how the nanostructuring of a copper target can be optimized for enhanced carbon ion acceleration over protons or Cu-ions. Specifically, a thin (≈0.25 μm) layer of 25–30 nm diameter Cu nanoparticles, sputter-deposited on a polished Cu-substrate, enhances the carbon ion energy by about 10-fold at a laser intensity of 1.2×1018  W/cm2. However, particles smaller than 20 nm have an adverse effect on the ion acceleration. Particle-in-cell simulations provide definite pointers regarding the size of nanoparticles necessary for maximizing the ion acceleration. The inherent contrast of the laser pulse is found to play an important role in the species selective ion acceleration.
Creating Anti-icing Surfaces via the Direct Immobilization of Antifreeze Proteins on Aluminum
Authors: Gwak Yunho , Park Ji-in , Kim Minjae , Kim Hong Suk , Kwon Myong Jong , Oh Seung Jin , Kim Young-Pil , Jin EonSeon 
Published: July 2015

AbstractCryoprotectants such as antifreeze proteins (AFPs) and sugar molecules may provide a solution for icing problems. These anti-icing substances protect cells and tissues from freezing by inhibiting ice formation. In this study, we developed a method for coating an industrial metal material (aluminum, Al) with AFP from the Antarctic marine diatom, Chaetoceros neogracile (Cn-AFP), to prevent or delay ice formation. To coat Al with Cn-AFP, we used an Al-binding peptide (ABP) as a conjugator and fused it with Cn-AFP. The ABP bound well to the Al and did not considerably change the functional properties of AFP. Cn-AFP-coated Al (Cn-AFP-Al) showed a sufficiently low supercooling point. Additional trehalose coating of Cn-AFP-Al considerably delayed AFP denaturation on the Al without affecting its antifreeze activity. This metal surface–coating method using trehalose-fortified AFP can be applied to other metals important in the aircraft and cold storage fields where anti-icing materials are critical.
Exciton-photon correlations in bosonic condensates of exciton-polaritons
Authors: Kavokin Alexey V. , Sheremet Alexandra S. , Shelykh Ivan A. , Lagoudakis Pavlos G. , Rubo Yuri G. 
Published: July 2015

AbstractExciton-polaritons are mixed light-matter quasiparticles. We have developed a statistical model describing stochastic exciton-photon transitions within a condensate of exciton polaritons. We show that the exciton-photon correlator depends on the rate of incoherent exciton-photon transformations in the condensate. We discuss implications of this effect for the quantum statistics of photons emitted by polariton lasers.