bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimers and Chains of Hydrogen bonded [HS2O7]– Anions in the Crystal Structures of M[HS2O7] (M = K, [NH4], [NO], Rb, Cs)
Authors: Schindler Lisa Verena , Daub Michael , Struckmann Mona , Weiz Alexander , Hillebrecht Harald , Wickleder Mathias S. 
Published: October 2015

AbstractThe reactions of KCl, [NH4]2[SO4], Rb2[CO3], and Cs2[CO3] with fuming sulfuric acid (65 % SO3) yielded colorless and moisture sensitive crystals of K[HS2O7] (monoclinic, P21/c (no. 14), Z = 4, a = 716.67(3) pm, b = 1043.57(4) pm, c = 828.78(3) pm, β = 107.884(1)°, V = 589.89(4) × 106 pm3), [NH4][HS2O7] (monoclinic, P21/c (no. 14), Z = 4, a = 729.29(1) pm, b = 1079.73(1) pm, c = 843.26(1) pm, β = 106.397(1)°, V = 637.01(1) × 106 pm3), Rb[HS2O7] (monoclinic, P21/c (no. 14), Z = 4, a = 724.49(2) pm, b = 1073.19(3) pm, c = 852.01(3) pm, β = 106.534(1)°, V = 635.06(3) × 106 pm3), and Cs[HS2O7] (triclinic, P (no. 2), Z = 2, a = 537.61(3) pm, b = 784.71(4) pm, c = 867.93(4) pm, α = 94.214(2)°, β = 103.138(2)°, γ = 105.814(2)°, V = 339.47(3) × 106 pm3). Colorless crystals of [NO][HS2O7] (monoclinic, P21/c (no. 14), Z = 4, a = 739.90(4) pm, b = 1048.00(5) pm, c = 830.97(4) pm, β = 106.985(2)°, V = 106.985(2) × 106 pm3) were obtained as a side product from the reaction of [NH4]2[Rh(NO2)4] with oleum (65 % SO3) in the ionic liquid [BMIm][OTf]. The crystal structures of K[HS2O7], [NH4][HS2O7], [NO][HS2O7], and Rb[HS2O7] show the [HS2O7]– ions linked into dimers by strong hydrogen bonds. Contrastingly, in the crystal structure of Cs[HS2O7] the [HS2O7]– ions are connected to infinite chains. Raman spectra were recorded for M[HS2O7] (M = K, Rb, Cs).
Treatment of Patients with Distant Metastases from Phyllodes Tumor of the Breast
Authors: Mituś J. W. , Blecharz P. , Walasek T. , Reinfuss M. , Jakubowicz J. , Kulpa J. 
Published: October 2015

AbstractBackgroundHere, the treatment methods and results of patients with phyllodes tumor of the breast (PT) with distant metastases at a single institution are presented.MethodsA retrospective analysis was performed on a group of 295 patients with PT treated from 1952 to 2010.ResultsDistant metastases developed in 37 (12.5 %) patients; 3/160 (1.9 %) patients had benign PT, 6/36 (16.7 %) were considered borderline, and 28/99 (28.3 %) had malignant PT. Most frequently, the metastases were located in the lungs; 28 (75.7 %), bone 7 (18.9 %), brain 4 (10.8 %), and liver 2 (5.4 %). Metastases occurred on overage 21 months (2–57) after surgery. Patients with lung metastases were generally treated with monochemotherapy or polychemotherapy. In one patient Testosterone and in two patients resection of metastases combined with Doxorubicin were used. Patients with bones or brain metastases were treated with palliative radiotherapy only or combined with Doxorubicin. The mean survival (MS) from diagnosis of distant metastases (DM) was 7 months (2–17). The longest mean survival in patients with bones metastases was 11.8 months, the worst survival was for patients with brain metastases—2.8 months. Hormone therapy appeared to have low efficacy (MS: 2 months) as well as monochemotherapy (MS: 3–5 months). Improved MS was obtained using Doxorubicin (7 months) and Doxorubicin with Cisplatin, Cyclophosphamide, or Ifosfamide (9 months).ConclusionThe prognosis of patients with DM from PT is poor. The role of surgery and irradiation of such patients is very limited. There appears to be no role for the use of hormone therapy. This study showed that polychemotherapy with Doxorubicin and Ifosfamide suggest that it might be more effective than once thought.
CAEP 2014 Academic Symposium: “How to make research succeed in your emergency department: How to develop and train career researchers in emergency medicine”
Authors: Perry Jeffrey J. , Snider Carolyn E. , Artz Jennifer D. , Stiell Ian G. , Shaeri Sedigheh , McLeod Shelley , Le Sage Natalie , Hohl Corinne , Calder Lisa A. , Vaillancourt Christian , Holroyd Brian , Hollander Judd E. , Morrison Laurie J. 
Published: October 2015

AbstractObjectivesWe sought to 1) identify best practices for training and mentoring clinician researchers, 2) characterize facilitators and barriers for Canadian emergency medicine researchers, and 3) develop pragmatic recommendations to improve and standardize emergency medicine postgraduate research training programs to build research capacity.MethodsWe performed a systematic review of MEDLINE and Embase using search terms relevant to emergency medicine research fellowship/graduate training. We conducted an email survey of all Canadian emergency physician researchers. The Society for Academic Emergency Medicine (SAEM) research fellowship program was analysed, and other similar international programs were sought. An expert panel reviewed these data and presented recommendations at the Canadian Association of Emergency Physicians (CAEP) 2014 Academic Symposium. We refined our recommendations based on feedback received.ResultsOf 1,246 potentially relevant citations, we included 10 articles. We identified five key themes: 1) creating training opportunities; 2) ensuring adequate protected time; 3) salary support; 4) infrastructure; and 5) mentorship. Our survey achieved a 72% (67/93) response rate. From these responses, 42 (63%) consider themselves clinical researchers (i.e., spend a significant proportion of their career conducting research). The single largest constraint to conducting research was funding. Factors felt to be positive contributors to a clinical research career included salary support, research training (including an advanced graduate degree), mentorship, and infrastructure. The SAEM research fellowship was the only emergency medicine research fellowship program identified. This 2-year program requires approval of both the teaching centre and each applying fellow. This program requires training in 15 core competencies, manuscript preparation, and submission of a large grant to a national peer-review funding organization.ConclusionsWe recommend that the CAEP Academic Section create a process to endorse research fellowship/graduate training programs. These programs should include two phases: Phase I: Research fellowship/graduate training would include an advanced research university degree and 15 core learning areas. Phase II: research consolidation involves a further 1-3 years with an emphasis on mentorship and scholarship production. It is anticipated that clinician scientists completing Phase I and Phase II training at a CAEP Academic Section-endorsed site(s) will be independent researchers with a higher likelihood of securing external peer-reviewed funding and be able to have a meaningful external impact in emergency medicine research.
Responsibility, Fraternity, and Sustainability in International Law
Authors: CRAWFORD JAMES 
Published: October 2015

AbstractThis article presents an account of international law and its possible future that revolves around three key themes: responsibility, fraternity, and sustainability. These three themes were promoted by Charles Doherty Gonthier, visionary justice of the Supreme Court of Canada from 1989 to 2003, for whom the inaugural lecture where this article was presented is named.
Critical slope for laminar transcritical shallow-water flows
Authors: Thual O. , Lacaze L. , Mouzouri M. , Boutkhamouine B. 
Published: October 2015

Backwater curves denote the depth profiles of steady flows in a shallow open channel. The classification of these curves for turbulent regimes is commonly used in hydraulics. When the bottom slope $I$ is increased, they can describe the transition from fluvial to torrential regimes. In the case of an infinitely wide channel, we show that laminar flows have the same critical height $h_{c}$ as that in the turbulent case. This feature is due to the existence of surface slope singularities associated to plug-like velocity profiles with vanishing boundary-layer thickness. We also provide the expression of the critical surface slope as a function of the bottom curvature at the critical location. These results validate a similarity model to approximate the asymptotic Navier–Stokes equations for small slopes $I$ with Reynolds number $Re$ such that $Re\,I$ is of order 1.
XXVI.—Solution of the Equation (z + b)eZ+a = ±(z − b)
Authors: Wright E. M. 
Published: October 2015

SYNOPSISThe roots of these equations are of importance in several theories and various authors have studied certain of their properties. Here we solve the equations in the sense that we define two numbers z(1), z(0), and a sequence {zn} which include the roots of both equations. Except for a small, finite number of values of n, we find a rapidly convergent series for zn whose terms are alternately real and purely imaginary. We give a number of expansions and a variety of practical methods which enable us to calculate the small number of remaining roots to any required degree of accuracy.The main results of this article have been announced without proof or details in Wright 1960.
CBT for adolescent pathological gambling – lessons from adult research
Authors: Clarke Ciaran , Skokauskas Norbertas 
Published: October 2015

AbstractObjectives:Features of gambling, particularly among young people have changed over the past decade and, while there are no data from Ireland, there are suggestions from those working in the field that pathological gambling is increasing among adolescents. Relatively little is known about the effective treatment of pathological gambling in adolescents. This paper aims to review research in cognitive behavioural treatments with a view to their application in adolescents. Research among adolescence is given prominence when this is available.Methods:The methodology comprised a literature search of Medline, Psycinfo, and EMBASE databases, using the search terms: ‘cognitive behavioural therapy’; ‘gambling; ‘psychology’; ‘epidemiology’; ‘adolescent’; ‘motivation’; ‘effectiveness’; ‘outcome’; ‘relapse’; and ‘internet’. In addition, a hand search ofClinical Psychological Reviews, Journal of Gambling Studies, Addiction, Psychology of Addictive Behaviors, and International Gambling Studies(1997-2007) was performed.Results:A total of 23 studies comprising various cognitive and behavioural approaches were identified, all but three of them confined to adult subjects. Study methodology and quality varied greatly, with many case studies or small case series, and only three randomised control trials. None used an intention-to-treat analysis, and there was little long-term follow-up. Almost ail indicated, with more or less evidence, that cognitive behavioural strategies might be beneficial.Conclusions:Many varieties and modifications of cognitive behavioural therapy have been applied to pathological gambling, though there are few studies of any psychological treatments for adolescent gamblers. Methodological problems surround much of the research. Notwithstanding these reservations cognitive behavioural approaches seem to offer promise in managing this serious problem.
Reflections on environmental education: past development and future concepts
Authors: Linke R.D. 
Published: October 2015

In attempting to review the recent progress and outline a few of the remaining problems in environmental education it is important, but also because of the scope of the task extremely difficult, to find a suitable structure that will provide some continuity. I have elected therefore to comment firstly on the fundamental issue of philosophy, of what we mean by environmental education and what we acknowledge as practical examples; secondly to discuss a few prominent issues of teaching and learning in four different spheres of education: primary and secondary schools, higher education (universities and colleges of advanced education), technical and further education (TAFE), and non-formal education; and lastly to comment on two general issues in environmental education that relate to the entire field, the first to participation and the need to identify and make suitable provision for those sections of the community who have as yet had no formal contact with environmental education, and the second to the special problems and teaching demands arising from its characteristic focus on the development of attitudes and values and appropriate behavioural change.To take firstly the issue of philosophy: it appears that the level of discussion on the nature and objectives of environmental education has advanced considerably in the past decade. The sometimes bitter and generally unproductive arguments of the early 1970s about what was and was not related to environmental education seem now to have largely disappeared, being replaced by a more or less common dialogue about the nature and purpose of environmental education and ways in which it can be further developed. Nevertheless, despite this general and encouraging trend there still exist some significant areas of disagreement and confusion. One example concerns the distinction between environmental education as a movement or collective enterprise and as a description of individual activities or programmes. This distinction is an important one because of different expectations — in the former case that it necessarily reflects an interdisciplinary character and has a clear emphasis on problem-solving and decision-making activities; but this is not to say that a particular programme which fails to reflect these emphases has nothing to contribute to environmental education.
Burnout among physicians in palliative care: Impact of clinical settings
Authors: Dréano-Hartz Soazic , Rhondali Wadih , Ledoux Mathilde , Ruer Murielle , Berthiller Julien , Schott Anne-Marie , Monsarrat Léa , Filbet Marilène 
Published: October 2015

AbstractObjective:Burnout syndrome is a work-related professional distress. Palliative care physicians often have to deal with complex end-of-life situations and are at risk of presenting with burnout syndrome, which has been little studied in this population. Our study aims to identify the impact of clinical settings (in a palliative care unit (PCU) or on a palliative care mobile team (PCMT)) on palliative care physicians.Method:We undertook a cross-sectional study using a questionnaire that included the Maslach Burnout Inventory (MBI), and we gathered sociodemographic and professional data. The questionnaire was sent to all 590 physicians working in palliative care in France between July of 2012 and February of 2013.Results:The response rate was 61, 8% after three reminders. Some 27 (9%) participants showed high emotional exhaustion, 12 (4%) suffered from a high degree of depersonalization, and 71 (18%) had feelings of low personal accomplishment. Physicians working on a PCMT tended (p = 0.051) to be more likely to suffer from emotional exhaustion than their colleagues. Physicians working on a PCMT worked on smaller teams (fewer physicians, p < 0.001; fewer nonphysicians, p < 0.001). They spent less time doing research (p = 0.019), had fewer resources (p = 0.004), and their expertise seemed to be underrecognized by their colleagues (p = 0.023).Significance of Results:The prevalence of burnout in palliative care physicians was low and in fact lower than that reported in other populations (e.g., oncologists). Working on a palliative care mobile team can be a more risky situation, associated with a lack of medical and paramedical staff.
Supporting members and friends
Authors: Anonymous  
Published: October 2015

Thank you! Over the past year, AGU has received 12,871 gifts, both large and small, from members and friends. The Union has also received corporate contributions, National Science Foundation grants, and support from the National Oceanographic Partnership Program. Together their generosity has benefited AGU non‐revenue‐producing programs that are critical to our science and the future health of the Union.The following list gratefully acknowledges annual gifts of $100 or more and cumulative giving of $5,000 or more. The 1919 Society ($100,000 or more) and Benefactors ($5,000–$99,999) recognize single major gifts and cumulative contributions. Three Circles acknowledge annual giving: President's Circle ($1,000 or more), Leadership Circle ($200–$999), and Supporters Circle ($100–$199). Supporting Life Members, who contribute a one‐time gift of $1,200 in addition to lifetime dues, are among our most loyal supporters.
Polygenic susceptibility to testicular cancer: implications for personalised health care
Authors: Litchfield Kevin , Mitchell Jonathan S , Shipley Janet , Huddart Robert , Rajpert-De Meyts Ewa , Skakkebæk Niels E , Houlston Richard S , Turnbull Clare 
Published: October 2015

AbstractBackground:The increasing incidence of testicular germ cell tumour (TGCT) combined with its strong heritable basis suggests that stratified screening for the early detection of TGCT may be clinically useful. We modelled the efficiency of such a personalised screening approach, based on genetic risk profiling in combination with other diagnostic tools.Methods:We compared the number of cases potentially detectable in the population under a number of screening models. The polygenic risk scoring (PRS) model was assumed to have a log-normal relative risk distribution across the 19 currently known TGCT susceptibility variants. The diagnostic performance of testicular biopsy and non-invasive semen analysis was also assessed, within a simulated combined screening programme.Results:The area under the curve for the TGCT PRS model was 0.72 with individuals in the top 1% of the PRS having a nine-fold increased TGCT risk compared with the population median. Results from population-screening simulations only achieved a maximal positive predictive value (PPV) of 60%, highlighting broader clinical factors that challenge such strategies, not least the rare nature of TGCT. In terms of future improvements, heritability estimates suggest that a significant number of additional genetic risk factors for TGCT remain to be discovered, identification of which would potentially yield improvement of the PPV to 80–90%.Conclusions:While personalised screening models may offer enhanced TGCT risk discrimination, presently the case for population-level testing is not compelling. However, future advances, such as more routine generation of whole genome data is likely to alter the landscape. More targeted screening programs may plausibly then offer clinical benefit, particularly given the significant survivorship issues associated with the successful treatment of TGCT.
Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy
Authors: Magown Philippe , Shettar Basavaraj , Zhang Ying , Rafuse Victor F. 
Published: October 2015

AbstractNeural prostheses can restore meaningful function to paralysed muscles by electrically stimulating innervating motor axons, but fail when muscles are completely denervated, as seen in amyotrophic lateral sclerosis, or after a peripheral nerve or spinal cord injury. Here we show that channelrhodopsin-2 is expressed within the sarcolemma and T-tubules of skeletal muscle fibres in transgenic mice. This expression pattern allows for optical control of muscle contraction with comparable forces to nerve stimulation. Force can be controlled by varying light pulse intensity, duration or frequency. Light-stimulated muscle fibres depolarize proportionally to light intensity and duration. Denervated triceps surae muscles transcutaneously stimulated optically on a daily basis for 10 days show a significant attenuation in atrophy resulting in significantly greater contractile forces compared with chronically denervated muscles. Together, this study shows that channelrhodopsin-2/H134R can be used to restore function to permanently denervated muscles and reduce pathophysiological changes associated with denervation pathologies.
TAK1 inhibition prevents the development of autoimmune diabetes in NOD mice
Authors: Cao Hui , Lu Jingli , Du Jiao , Xia Fei , Wei Shouguo , Liu Xiulan , Liu Tingting , Liu Yang , Xiang Ming 
Published: October 2015

AbstractTransforming growth factor-β activated kinase-1 (TAK1, Map3k7), a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, is essential in innate and adaptive immune responses. We postulated that blockade of TAK1 would affect autoimmune diabetes in non-obese diabetic (NOD) mice. Administration of 5Z-7-oxozeaenol (OZ), a TAK1 inhibitor, decreased the incidence and delayed the onset of autoimmune diabetes in both spontaneous and accelerated (cyclophosphamide-induced) experimental NOD mice. OZ also reduced insulitis, preserved islet function, increased the expression of α1- antitrypsin (AAT) and severely inhibited NF-κB and JNK/AP-1 signaling pathways in immune organs and pancreatic tissues. Importantly, TAK1 inhibition by OZ elicited a Th1 to Th2 cytokine shift and increased TGF-β1 production in cultured T lymphocytes supernatants. Systemic TAK1 inhibition induced immature DCs with lower expressions of MHC-II and CD86, attenuated DC-mediated T cell proliferation in allogeneic MLR and production of cytokine IL-12p70 in DCs suspensions. The results indicate that TAK1 inhibition with OZ was associated with a lower frequency of autoimmune diabetes in NOD mice. The net effect of TAK1 inhibition in NOD mice therefore appears to be protective rather than disease-enhancing. Strategies targeting TAK1 specifically in NOD mice might prove useful for the treatment of autoimmune diabetes in general.
Light-induced atomic desorption in a compact system for ultracold atoms
Authors: Torralbo-Campo Lara , Bruce Graham D. , Smirne Giuseppe , Cassettari Donatella 
Published: October 2015

AbstractIn recent years, light-induced atomic desorption (LIAD) of alkali atoms from the inner surface of a vacuum chamber has been employed in cold atom experiments for the purpose of modulating the alkali background vapour. This is beneficial because larger trapped atom samples can be loaded from vapour at higher pressure, after which the pressure is reduced to increase the lifetime of the sample. We present an analysis, based on the case of rubidium atoms adsorbed on pyrex, of various aspects of LIAD that are useful for this application. Firstly, we study the intensity dependence of LIAD by fitting the experimental data with a rate-equation model, from which we extract a correct prediction for the increase in trapped atom number. Following this, we quantify a figure of merit for the utility of LIAD in cold atom experiments and we show how it can be optimised for realistic experimental parameters.
Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes Proliferation of Articular Chondrocytes through Activation of AKT and Smad2/3
Authors: Tian Kang , Zhong Weiliang , Zheng Xifu , Zhang Jinrui , Liu Pixu , Zhang Weiguo , Liu Han 
Published: October 2015

AbstractCartilage defect is an intractable clinical problem. Therapeutic strategies for cartilage repair are far from optimal due to poor proliferation capacity of chondrocytes. Autologous chondrocyte implantation is a cell based therapy that uses in vitro amplified healthy chondrocytes from the patient. However, chondrocyte dedifferentiation during in vitro culture limits its application. Neuroleukin (NLK) is a multifunctional protein that stimulates cell growth and migration, together with its receptor autocrine motility factor receptor (AMFR, also called gp78). We investigated expression of NLK and AMFR/gp78 during cartilage development in vivo and in cultured articular chondrocytes in vitro and found the pair associates with chondrocyte proliferation and differentiation. While applied to isolated articular chondrocytes, NLK promotes cell proliferation and secretion of type II collagen, a marker of proliferating chondrocytes. Further work demonstrates that NLK up regulates pAKT and pSmad2/3, but down regulates pSmad1/5. In animals, NLK treatment also promotes chondrocyte proliferation while inhibits terminal differentiation, leading to expanded proliferating zone but decreased prehypertrophic and hypertrophic zones in the growth plate region. NLK is therefore a candidate factor that can be applied in the treatment of cartilage defects.