bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features, haemodynamics, and outcomes of heart failure with preserved ejection fraction in coarctation of aorta
Authors: Egbe Alexander C. , Reddy Yogesh N.V. , Ali Ahmed E. , Younis Ahmed , Borlaug Barry A. 
Published: July 2024

AimsThere are similarities in the pathogenesis of cardiac remodelling and dysfunction in heart failure with preserved ejection fraction (HFpEF) and coarctation of aorta (COA). We hypothesized that clinical HFpEF would be highly prevalent in adults with COA, and that the presence of HFpEF would increase the risk of mortality in this population. The aim of this study was to define the clinical features, haemodynamics, and prognostic implications of HFpEF in COA.Methods and resultsConsecutive adults with repaired COA that underwent right heart catheterization were identified retrospectively. HFpEF was defined as heart failure symptoms (exertional dyspnoea or fatigue), preserved left ventricular ejection fraction ≥50%, and pulmonary artery wedge pressure at rest >15 mmHg. Of 99 COA patients, 32 (32%) had HFpEF. The correlates of HFpEF were obesity (adjusted odds ratio [OR] 4.15, 95% confidence interval [CI] 1.31–13.2), atrial fibrillation (adjusted OR 3.13, 95% CI 1.00–10.7), total arterial compliance index (adjusted OR 0.12, 95% CI 0.06–0.41 per 1 ml/mmHg*m2), and pulmonary artery compliance index (adjusted OR 0.36, 95% CI 0.15–0.56 per 1 ml/mmHg*m2). Of 99 patients, 24 (24%) died and 5 (5%) underwent heart transplant. The 10‐year cumulative incidence of death/transplant was higher in COA patients with HFpEF compared with patients without HFpEF (39% vs. 12%, p = 0.001). The presence of HFpEF was associated with increased risk of death/transplant (adjusted hazard ratio 1.68, 95% CI 1.16–3.11).ConclusionsHeart failure with preserved ejection fraction is common in adults with COA and is associated with greater risk of death/transplant, emphasizing a pressing need for interventions to prevent and treat HFpEF in COA.
Highly Efficient Carbonylation of Propylene Oxide into β‐Butyrolactone Catalyzed over Co‐Al Bimetallic Species†
Authors: Zou Haoyu , Li Lincai , Cui Linxiao , Peng Li , Li Jun , Zhu Hongping 
Published: July 2024

AbstractRational designation of the catalyst for efficient atom‐economic conversion of propylene oxide (PO) and carbon monoxide (CO) into β‐butyrolactone is of current significance. By employing the O,N,O‐tridentate ligands R1,R2LH2 (1–4), the aluminium compounds (R1,R2LAlCl)2 (R1,R2=H,H (5), tBu,tBu (6), Cl,Cl (7), Br,Br (8)) and the derived anion‐cation pairs [H,HLAl(THF)3]+[Co(CO)4]− (9) and [(R1,R2LAl)2Cl(THF)2]+[Co(CO)4]− (R1,R2=tBu,tBu (10), Cl,Cl (11), Br,Br (12)) as well as the aluminium‐cobalt bimetallic cluster compounds [(R1,R2LAl)2Cl(THF)][Co3(CO)10] (R1,R2=tBu,tBu (13), Cl,Cl (14), Br,Br (15)) were prepared. Compounds 9–12 efficiently catalyzed the PO carbonylation into β‐butyrolactone to achieve up 93.4–98.9 % yields while 13–15 gained 95.2–99.0 % yields all at 25 °C and 0.1 MPa CO pressure. The Lewis acidic property of the aluminium compounds 5–8 was investigated. The kinetic of the catalytic reaction using compound 10 was studied. The cooperatively catalytic reaction mechanism by the Co−Al bimetallic species is proposed.
Synthesis, Structure, and Resolution of Functionalized Oxacalix[4]arenes with Planar Chirality via Dynamic SNAr Reaction
Authors: Yang Yong , Yu Yin‐Chong , Xue Min , Peng Wei‐Wei , Xue Bo‐Wen , Zong Qian‐Shou 
Published: July 2024

AbstractA pair of racemic oxacalix[4]arenes featuring planar chirality and a mesomer with a symmetric plane were conveniently synthesized under mild conditions via a one‐pot dynamic SNAr reaction and separated in 20 % and 49 % yields, respectively. X‐ray single crystal analyses confirmed their structures unambiguously. The racemic mixture could further be resolved using HPLC on a chiral column. Time‐dependent products distribution and interconversion between products with CsF as a catalyst were revealed by 1H NMR studies, convincing the dynamic nature of SNAr reaction.
Asymmetric Synthesis of Seven‐Membered Lactams: Recent Advances and Future Perspectives
Authors: Xie Danyang , Zhong Sishi , Xia Yong 
Published: July 2024

AbstractThe optically active lactams represent an important structural motif and present in a wide range of natural products, biologically active compounds and drugs. Compared to the synthesis of chiral five‐ and six‐membered lactams, the asymmetric construction of seven‐membered lactams often presents a challenge due to their consequential entropic and enthalpic barriers. Over the past few decades, substantial efforts have been devoted to this field and chemists have developed various efficient strategies for the preparation of seven‐membered lactams. In this review, we will highlight the recent advances in enantioselective formation of seven‐membered lactams and the discussion will be logically divided into three parts according to the reaction mode. The aim of this review is to familiarize the Reader with new synthetic opportunities offered by these interesting methodologies.
Elucidating the antimicrobial and anticarcinogenic potential of methanolic and water extracts of edible Tragopogon coelesyriacus Boiss.
Authors: Unver Tuba , Uzuner Ugur , Celik‐Uzuner Selcen , Gurhan Ismet , Sivri Nur Sena , Ozdemir Zeynep 
Published: July 2024

AbstractTragopogon coelesyriacus is a pharmacotherapeutic herbaceous plant belonging to the Asteraceae family and consumed as a vegetable. Here, the methanolic and water extracts of T. coelesyriacus were obtained from its aboveground parts (stem, leaves, and flowers), and the phytochemical potentials were investigated by LC‐HRMS (liquid chromatography–high resolution mass spectrometry) analysis for the first time. The antibacterial, antifungal, and anticarcinogenic activities of T. coelesyriacus extracts were investigated using experimental and in silico methods. T. coelesyriacus methanol extract revealed remarkable inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumonia (MICs = 0.83, 1.67, and 1.67 mg/mL, respectively) compared to Escherichia coli and Enterobacter aerogenes (MIC = 53.3 mg/mL). Inhibitory effects of T. coelesyriacus methanolic extracts were also observed in all Candida species tested, with the highest inhibition on Candida krusei (MIC = 0.83 mg/mL), whereas no inhibitory effect was identified from the water extract. Additionally, both T. coelesyriacus methanolic (IC50 = 86 μg/mL) and water (IC50 = 92 μg/mL) extracts revealed significant selective anticarcinogenic effects on AR42J pancreatic cancer cells. HeLa and MDA‐MB‐231 cells were, however, more resilient to methanol and water extract, respectively. In silico analyses further elucidated the noteworthy antibacterial potential of keracyanin chloride on S. aureus MurB enzyme and the remarkable inhibitory potential of naringin on FYN kinase specific for pancreatic cancer (AR42J) development. In conclusion, T. coelesyriacus phytochemicals with antibacterial, antifungal, and anticancer properties were revealed for the first time, and molecular docking studies on potential targets confirmed good agreement with experimental findings. Therefore, the current studies on T. coelesyriacus provide the basis for investigating new pharmaceutical potentials of other Tragopogon members.
Usefulness of low‐cost simulation models to learning surgical techniques for placenta accreta spectrum: An observational educational study
Authors: Nieto‐Calvache Albaro José , Palacios‐Jaraquemada José Miguel , Fox Karin A. , Benavides Juan Pablo , Sarria‐Ortiz Daniela , Muñoz‐Córdoba Laura , Galindo‐Velasco Valentina , Maya Juliana , Meade Paulo , Romero Eduardo , Mostajo Desiré , Delgado Jorge , de la Cruz Antonio , Valladares Alexis , Sánchez Amadeo , Fernández Julio , Pavón Néstor , Solo‐Nieto Alejandro , Burgos Juan Manuel , Messa‐Bryon Adriana , Hussein Ahmed M. 
Published: July 2024

AbstractObjectiveTo evaluate the utility of low‐cost simulation models to teach surgical techniques for placenta accreta spectrum (PAS), included in a multimodal education workshop for PAS.MethodsThis was an observational, survey‐based study. Participants were surveyed before and after the use of low‐fidelity mannequins to simulate two surgical techniques for PAS (one‐step conservative surgery [OSCS] and modified subtotal hysterectomy [MSTH]), within a multimodal educational workshop. The workshops included pre‐course preparation, didactics, simulated practice of the techniques using low‐cost models, and viewing live surgery.ResultsSix OSCS/MSTH training workshops occurred across six countries and a total of 270 participants were surveyed. The responses of 127 certified obstetricians and gynecologists (OB–GYNs) were analyzed. Participants expressed favorable impressions of all components of the simulated session. Perceived anatomical simulator fidelity, scenario realism, educational component effectiveness, and self‐assessed performance improvement received ratings of 4–5 (positive end of the Likert scale) from over 90% of respondents. When asked about simulation's role in technique comprehension, comfort level in technique performance, and likelihood of recommending this workshop to others, more than 75% of participants rated these aspects with a score of 4–5 (positively) on the five‐point scale.ConclusionLow‐cost simulation, within a multimodal education strategy, is a well‐accepted intervention for teaching surgical techniques for PAS.
The relationship between traumatic childbirth perception, desire to avoid pregnancy, and sexual quality of life in women
Authors: Calpbinici Pelin 
Published: July 2024

AbstractObjectiveTo identify factors influencing women's perceptions of traumatic childbirth (TCP) and to determine the relationship between TCP, desire to avoid pregnancy, and sexual quality of life.MethodsA descriptive and correlational research study was designed. Data were collected from 225 women aged between 18 and 45 years old. A Demographic Information Form, the Desire to Avoid Pregnancy Scale (DAP), the Sexual Quality of Life Questionnaire‐Female (SQLQ‐F), and the Perception of Traumatic Childbirth Scale (PTCS) were used for data collection.ResultsWomen who were not employed, had given birth previously, and did not plan their last pregnancy tended to have higher levels of TCP. Conversely, women who did not experience health problems in their last pregnancy and recalled their last childbirth as very comfortable and happy tended to have lower levels of TCP. A very weak, statistically significant, positive correlation was found between the mean DAP and PTCS scores (r = 0.168, P < 0.05). A very weak, statistically significant, negative correlation was found between the mean SQLQ‐F and PTCS sores (r = −0.138, P < 0.05). A 1‐unit increase in TCP was associated with a 0.005‐unit increase in the desire to avoid pregnancy and a 0.094‐unit decrease in sexual quality of life.ConclusionTCP in women is associated with an increase in the desire to avoid pregnancy and a decrease in sexual quality of life. It is recommended to identify women with high levels of TCP, determine factors contributing to this perception, and plan appropriate nursing interventions accordingly.
Convolutional Neural Network‐Based CT Image Segmentation of Kidney Tumours
Authors: Hu Cong , Jiang Wenwen , Zhou Tian , Wan Chunting , Zhu Aijun 
Published: July 2024

ABSTRACTKidney tumours are one of the most common tumours in humans and the main current treatment is surgical removal. The CT images are usually manually segmented by a specialist for pre‐operative planning, but this can be influenced by the surgeon's experience and skill and can be time‐consuming. Due to the complex lesions and different morphologies of kidney tumours that make segmentation difficult, this article proposes a convolutional neural network‐based automatic segmentation method for CT images of kidney tumours to address the most common problems of boundary blurring and false positives in tumour segmentation images. The method is highly accurate and reliable, and is used to assist doctors in surgical planning as well as diagnostic treatment, relieving medical pressure to a certain extent. The EfficientNetV2‐UNet segmentation model proposed in this article includes three main parts: feature extractor, reconstruction network and Bayesian decision algorithm. Firstly, for the phenomenon of tumour false positives, the EfficientNetV2 feature extractor, which has high training accuracy and efficiency, is selected as the backbone network, which extracts shallow features such as tumour location, morphology and texture in the CT image by downsampling. Secondly, on the basis of the backbone network, the reconstruction network is designed, which mainly consists of conversion block, deconvolution block, convolution block and output block. Then, the up‐sampling architecture is constructed to gradually recover the spatial resolution of the feature map, fully identify the contextual information and form a complete encoding–decoding structure. Multi‐scale feature fusion is achieved by superimposing all levels of feature map channels on the left and right sides of the network, preventing the loss of details and performing accurate tumour segmentation. Finally, a Bayesian decision algorithm is designed for the edge blurring phenomenon of segmented tumours and cascaded over the output of the reconstruction network, combining the edge features of the original CT image and the segmented image for probability estimation, which is used to improve the accuracy of the model edge segmentation. Medical images in NII special format were converted to Numpy matrix format using python, and then more than 2000 CT images containing only kidney tumours were selected from the KiTS19 dataset as the dataset for the model, and the dimensions were standardised to 128 × 128, and the experimental results show that the model outperforms many other advanced models with good segmentation performance.
ADRs and Audit Pricing: Influence of disclosure and legal environment regime
Authors: Callaghan Joseph , Cho Seong , Kim Junwoo , Parkash Mohinder 
Published: July 2024

AbstractCross‐listed firms natively operate in countries where regulations are less enforced, disclosure requirements and the legal environment are laxer than in the US. Thus, cross‐listed firms typically pay lower audit fees than US peer groups. Based on reported audit data of the cross‐listed firms in the US, this study explores how their home country's regulatory environment affects audit fees when they cross‐list on US stock exchanges. The empirical results indicate that the cross‐listed firms pay lower audit fees than their US counterparts. However, other regulatory environments in the home country, like disclosure requirements or anti‐director dictatorship, may require more audit efforts. Further, the cross‐listed firms that prepare reconciliation to US GAAP pay lower audit fees than other ADR firms that are using IFRS or US GAAP. However, still most of ADR firms pay lower audit fees than US counterpart firms.
Expression patterns of keratin family members during tooth development and the role of keratin 17 in cytodifferentiation of stratum intermedium and stellate reticulum
Authors: Inada Saori , Chiba Yuta , Tian Tian , Sato Hiroshi , Wang Xin , Yoshizaki Keigo , Oka Sae , Yamada Aya , Fukumoto Satoshi 
Published: July 2024

AbstractKeratins are typical intermediate filament proteins of the epithelium that exhibit highly specific expression patterns related to the epithelial type and stage of cellular differentiation. They are important for cytoplasmic stability and epithelial integrity and are involved in various intracellular signaling pathways. Several keratins are associated with enamel formation. However, information on their expression patterns during tooth development remains lacking. In this study, we analyzed the spatiotemporal expression of keratin family members during tooth development using single‐cell RNA‐sequencing (scRNA‐seq) and microarray analysis. scRNA‐seq datasets from postnatal Day 1 mouse molars revealed that several keratins are highly expressed in the dental epithelium, indicating the involvement of keratin family members in cellular functions. Among various keratins, keratin 5 (Krt5), keratin 14 (Krt14), and keratin 17 (Krt17) are highly expressed in the tooth germ; KRT17 is specifically expressed in the stratum intermedium (SI) and stellate reticulum (SR). Depletion of Krt17 did not affect cell proliferation in the dental epithelial cell line SF2 but suppressed their differentiation ability. These results suggest that Krt17 is essential for SI cell differentiation. Furthermore, scRNA‐seq results indicated that Krt5, Krt14, and Krt17 exhibited distinct expression patterns in ameloblast, SI, and SR cells. Our findings contribute to the elucidation of novel mechanisms underlying tooth development.
Factors associated with skeletal muscle mass in middle‐aged men living with HIV
Authors: Xu Yide , Wang Dongdong , Chen Pei , Qi Bufeng , Li Xiaoting , Xie Chunfeng , Wu Jieshu , Li Lin , Gao Gu , Geng Shanshan , Yang Dandan 
Published: July 2024

AbstractBackgroundDespite extensive research on muscle loss in people living with HIV (PLWH), the prevalence and contributing factors specifically among middle‐aged men remain unclear. This study aimed to determine the prevalence of low muscle mass within this demographic and to identify associated factors.MethodsA total of 378 men living with HIV were enrolled in the study. They were classified into low muscle mass group if they displayed a skeletal muscle index (SMI) <7.00 kg/m2 or fell within the lowest quintile of SMI based on the criteria established by the Asian Working Group for Sarcopenia 2019.ResultsOut of the 378 men living with HIV enrolled, 351 had normal muscle mass, while 27 (7.1%) had low muscle mass. Antiretroviral drugs Zidovudine (AZT) (OR = 0.246, P = 0.022) and higher serum albumin levels (OR = 0.899, P = 0.026) were found to be protective factors against low muscle mass according to quintile grouping. Strong positive associations between SMI and body mass index (BMI), nutritional risk index (NRI), oedema index and fat‐free mass index (FFMI) (R > 0.5, P < 0.001) were observed. In addition, both BMI (sensitivity = 0.741, specificity = 0.906) and NRI (sensitivity = 0.963, specificity = 0.601) had high sensitivity and specificity in diagnosing low muscle mass, with critical values of 19.85 and 114.177 for BMI and NRI, respectively. The oedema index was the most effective measure of body composition in detecting abnormal fluid retention with high sensitivity (92.6%) and moderate specificity (71.8%) in identifying individuals with low muscle mass. Notably, PLWH with low muscle mass participants had a significantly higher prevalence (92.6%) of a high oedema index compared with those with normal muscle mass (28.2%). This observation indicates that individuals with HIV who experience reduced muscle mass is commonly accompanied with abnormal fluid retention within the body.ConclusionsAntiretroviral medication types, specifically Zidovudine, BMI and NRI can be independent risk factors for low muscle mass in men with HIV. These factors, along with BMI, could be used conveniently to predict low muscle mass. Furthermore, the association between the oedema index and muscle mass suggests that observing signs of oedema may indicate a risk of low muscle mass in PLWH.
Dynamic evolution of COVID‐19 vaccine hesitancy over 2021–2023 among Chinese population: Repeated nationwide cross‐sectional study
Authors: Shen Zhanlei , Li Quanman , Wu Jian , Zhu Dongfang , Bai Junwen , Ren Ruizhe , Zhang Jingbao , Li Yi , Wang Meiyun , Gu Jianqin , Li Yinfei , Dong Wenyong , Wang Haipeng , Sun Tao , Yang Fan , Zhou Xue , Yang Jian , Tarimo Clifford Silver , Ma Mingze , Feng Yifei , Miao Yudong 
Published: July 2024

AbstractGlobally, the rollout of COVID‐19 vaccine had been faced with a significant barrier in the form of vaccine hesitancy. This study adopts a multi‐stage perspective to explore the prevalence and determinants of COVID‐19 vaccine hesitancy, focusing on their dynamic evolutionary features. Guided by the integrated framework of the 3Cs model (complacency, confidence, and convenience) and the EAH model (environmental, agent, and host), this study conducted three repeated national cross‐sectional surveys. These surveys carried out from July 2021 to February 2023 across mainland China, targeted individuals aged 18 and older. They were strategically timed to coincide with three critical vaccination phases: universal coverage (stage 1), partial coverage (stage 2), and key population coverage (stage 3). From 2021 to 2023, the surveys examined sample sizes of 29 925, 6659, and 5407, respectively. The COVID‐19 vaccine hesitation rates increased from 8.39% in 2021 to 29.72% in 2023. Urban residency, chronic condition, and low trust in vaccine developer contributed to significant COVID‐19 vaccine hesitancy across the pandemic. Negative correlations between the intensity of vaccination policies and vaccine hesitancy, and positive correlations between vaccine hesitancy and long COVID, were confirmed. This study provides insights for designing future effective vaccination programs for emerging vaccine‐preventable infectious X diseases.
The impacts of global warming on climate zones over China based on CMIP6 models
Authors: Wang Siyi , Mei Ying , Liu Qianze , He Wenping 
Published: July 2024

AbstractClimate zones are expected to shift in response to climate change, which significantly influences vegetation distribution and provides essential guidance for human activities including production, lifestyle and economic development. Quantifying the shifts in climate zones due to global warming is therefore crucial. The primary metric for categorizing climate zones is the number of days with a daily mean temperature above 10°C (DT10). Utilizing DT10 and the ERA5 reanalysis data, it is observed that climate zones in China have gradually shifted northward over the past 65 years. Notably, the interdecadal changes in the climate zones differ between the eastern and western regions divided by the 110°E longitude. The western regions show minimal shifts, whereas the eastern regions, particularly the central and southern parts of Northeast China, exhibit obvious northward shifts. Consequently, the simulation capabilities of 41 CMIP6 models for Chinese climate zones were assessed, and it was found that 11 models demonstrated robust performance. These models were further used to analyse interdecadal variations and project future shifts in climate zones in China. The results show that the spatial pattern of climate zones in China can be well captured by the CMIP6 models, except for ACCESS‐CM2, FGOALS‐g3 and GFDL‐CM4. Each CMIP6 model seems to be more suitable for specific climatic zones concerning trends and decadal variations in China. By 2100, a northward shift is projected for all climate zones in the east of 110°E under SSP2‐4.5 and SSP5‐8.5 emission scenarios, particularly in northern China. It should be noted that the potential disappearance of the northern subtropical belt, likely to be replaced by the middle subtropical belt in the future.