bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub‐Nanosheet Induced Inverse Growth of Negative Valency Au Clusters for Tumor Treatment by Enhanced Oxidative Stress
Authors: Wang Dong , Yuan Feng , Deng Xuliang , Liu Qingda , Shi Wenxiong , Wang Xun 
Published: July 2024

AbstractCluster aggregation states are thermodynamically favored at the subnanoscale, for which an inverse growth from nanoparticles to clusters may be realized on subnanometer supports. Herein, we develop Au‐polyoxometalate‐layered double hydroxide (Au‐POM‐LDH) sub‐1 nm nanosheets (Sub‐APL) based on the above strategy, where sub‐1 nm Au clusters with negative valence are generated by the in situ disintegration of Au nanoparticles on POM‐LDH supports. Sub‐1 nm Au clusters with ultrahigh surface atom ratios exhibit remarkable efficiency for glutathione (GSH) depletion. The closely connected sub‐1 nm Au with negative valence and POM hetero‐units can promote the separation of hole‐electrons, resulting in the enhanced reactive oxygen species (ROS) generation under ultrasound (US). Besides, the reversible redox of Mo in POM is able to deplete GSH and trigger chemodynamic therapy (CDT) simultaneously, further enhancing the oxidative stress. Consequently, the Sub‐APL present 2‐fold ROS generation under US and 7‐fold GSH depletion compared to the discrete Au and POM‐LDH mixture. Therefore, the serious imbalance of redox in the TME caused by the sharp increase of ROS and rapid decrease of GSH leads to death of tumor ultimately.
Phenotyping variability in early socio‐communicative skills in young children with autism and its influence on later development
Authors: Journal Fiona , Franchini Martina , Godel Michel , Kojovic Nada , Latrèche Kenza , Solazzo Stefania , Schneider Maude , Schaer Marie 
Published: July 2024

AbstractChildren with autism spectrum disorder (ASD) often face challenges in early social communication skills, prompting the need for a detailed exploration of specific behaviors and their impact on cognitive and adaptive functioning. This study aims to address this gap by examining the developmental trajectories of early social communication skills in preschoolers with ASD aged 18–60 months, comparing them to age‐matched typically developing (TD) children. Utilizing the early social communication scales (ESCS), the research employs a longitudinal design to capture changes over time. We apply a principal component analysis (PCA) to ESCS variables to identify underlying components, and cluster analysis to identify subgroups based on preverbal communication profiles. The results reveal consistent differences in early social communication skills between ASD and TD children, with ASD children exhibiting reduced skills. PCA identifies two components, distinguishing objects‐directed behaviors and social interaction‐directed behaviors. Cluster analysis identifies three subgroups of autistic children, each displaying specific communication profiles associated with distinct cognitive and adaptive functioning trajectories. In conclusion, this study provides a nuanced understanding of early social communication development in ASD, emphasizing the importance of low‐level behaviors. The identification of subgroups and their unique trajectories contributes to a more comprehensive understanding of ASD heterogeneity. These findings underscore the significance of early diagnosis, focusing on specific behaviors predicting cognitive and adaptive functioning outcomes. The study encourages further research to explore the sequential development of these skills, offering valuable insights for interventions and support strategies.
Exploring the role of neutral ligands in modulating the photoluminescence of samarium complexes with 1,1,1,5,5,5‐hexafluoro‐2,4‐pentanedione
Authors: Malik Sofia , Jakhar Komal , Singh Devender , Dalal Swati , Hooda Anjli , Nehra Kapeesha , Kumar Sumit , Malik Rajender Singh , Kumar Parvin 
Published: July 2024

AbstractFour eight‐coordinated luminescent samarium complexes of type [Sm(hfpd)3L2] and [Sm(hfpd)3L′] [where hfpd = 1,1,1,5,5,5‐Hexafluoro‐2,4‐pentanedione L = tri‐octyl‐phosphine oxide (TOPO) and L′ = 1,10‐phenanthroline (phen), neocuproine (neoc) and bathocuproine (bathoc) were synthesized via a stoichiometrically controlled approach. This allows for precise control over the stoichiometry of the complexes, leading to reproducible properties. This investigation focuses on understanding the impact of secondary ligands on the luminescent properties of these complexes. Infrared (IR) spectra provided information about the molecular structures, whereas 1H and 13C nuclear magnetic resonance (NMR) spectra confirmed these structural details along with the coordination of ligands to trivalent Sm ion. The UV–vis spectra revealed the molar absorption coefficient and absorption bands associated with the hfpd ligand and photoluminescence (PL) spectroscopy demonstrated intense orange‐red emission (648 nm relative to 4G5/2 → 6H9/2) from the complexes. The Commission Internationale de l'Éclairage (CIE) triangles indicated that the complexes emitted warm orange red light with color coordinates (x, y) ranging from (0.62, 0.36) to (0.40, 0.27). The investigation of the band gap as well as color parameters confirms the utility of these complexes in displays and LEDs.
A highly sensitive spectrofluorimetric method for the determination of bilastine in human plasma: Application of content uniformity testing
Authors: Omar Mahmoud A. , Khojah Hani M. J. , Al Thagfan Sultan S. , Alolayan Sultan Othman , Attia Tamer Z. 
Published: July 2024

AbstractBilastine, a new second generation antihistaminic drug, has been widely used for relieving symptoms of allergic rhinitis and urticaria without a sedative effect. A simple, cost‐effective, and highly sensitive fluorimetric method was developed for the estimation of bilastine in human plasma, in addition to its pure state and tablets. The suggested method depended on binary complex formation of eosin with bilastine in a buffered medium at pH 4.2. The formed complex resulted in quantitative quenching of eosin emission at 538 nm after excitation at 335 nm. This method demonstrates a broad range of linearity, spanning from 200 to 1000 ng/mL, and exhibits exceptional sensitivity, with a limit of detection and quantitation of 30.85 and 93.48 ng/mL, respectively. In addition, this spectrofluorimetric method may be employed to determine the amount of bilastine in human plasma and tablets with satisfactory accuracy and excellent precision. Furthermore, the content uniformity of bilastine in commercially available tablets was successfully tested by this approach. Compared with the reference method, there were no significant variations in terms of precision or accuracy. In conclusion, the proposed protocol is highly recommended to quantitatively estimate bilastine in different quality control settings.
Preparation of imidazolium ionic liquid functionalized paper membrane for selective extraction of caffeic acid and its structural and functional analogues from Taraxaci Herba
Authors: Han Xiaohui , Li Shumin , Sun Xiaoxue , Zhang Jingyu , Zhang Xuerui , Bi Xiaodong 
Published: July 2024

AbstractIn the search for pharmaceutically active compounds from natural products, it is crucial and challenging to develop separation or purification methods that target not only structurally similar compounds but also those with specific pharmaceutical functions. The adsorption‐based method is widely employed in this field and holds potential for this application, given the diverse range of functional monomers that can be chosen based on structural or functional selectivity. In this work, an imidazolium ionic liquid (IL) modified paper membrane was synthesized via microwave reaction. Caffeic acid (CA), with potential interactions with imidazolium IL and a representative component of phenolic acids in Taraxaci Herba, was chosen as a target compound. After optimization of synthesis and extraction parameters, the resulting extraction membrane could be used to quantitatively analyze CA at ng/ml level, and to extract CA's analogues from the sample matrix. Cheminformatics confirmed the presence of structural and functional similarity among these extracted compounds. This study offers a novel approach to preparing a readily synthesized extraction membrane capable of isolating compounds with structural and functional analogies, as well as developing a membrane solid‐phase extraction‐based analytical method for natural products.
Mendelian randomization highlights sleep disturbances mediated the effect of depression on chronic pain
Authors: Zhu Yingchao , Bi Yaodan , Zhu Tao 
Published: July 2024

AbstractIntroductionDepression and chronic pain are significant contributors to the global burden of disease. Previous research has revealed complex relationships between these two conditions, which may be influenced by sleep quality. However, observational studies have limitations, including confounding factors and reverse causation. This study aims to explore the mediating effects of sleep on the relationship between depression and chronic pain using Mendelian randomization (MR).MethodsWe conducted a two‐step, two‐sample MR study using mediation analysis. We obtained major depressive disorder (MDD) Genome‐Wide Association Studdies (GWAS) data from Wray et al.’s GWAS meta‐analysis. Phenotypic data related to sleep were collected from the UK Biobank. Chronic pain data were obtained from the Finnish database.ResultsMR analysis revealed significant genetic associations between MDD and chronic localized pain [IVW: odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.16–1.38, p = 2.52 × 10–7] as well as fibromyalgia (IVW: OR = 2.17, 95% CI = 1.34–3.52, p = .002). Genetic susceptibility for MDD was also associated with insomnia (IVW: OR = 1.10, 95% CI = 1.06–1.13, p = 3.57 × 10–8) and self‐reported short sleep duration (IVW: OR = 1.03, 95% CI = 1.00–1.06, p = .047). The mediating effects of insomnia and fibromyalgia on the pathway from depression to chronic regional pain were 1.04 and 1.03, respectively, with mediation proportions of 12.8% and 15.2%. Insomnia mediated the pathway between depression and fibromyalgia with an effect of 1.12, accounting for 15.2% of the total effect.ConclusionThis two‐step MR analysis strengthens the evidence of genetic predictive associations between depression and chronic pain, highlighting the mediating roles of insomnia and short sleep duration. It further elucidates the specific roles of distinct sleep disorders, differentiating insomnia and short sleep duration from other sleep‐related phenotypes.
The role of managerial overconfidence in digital transformation and sustainable competitive performance in emerging SMEs: The role of digital culture
Authors: Khattak Muhammad Sualeh , Wu Qiang , Ahmad Maqsood , Hattab Insaf 
Published: July 2024

AbstractGrounded in upper echelons theory, this research contributes to the current literature on SME digital transformation by leveraging empirical data from 372 SMEs in an emerging economy. The study investigates the influence of overconfident managers on digital transformation and its subsequent impact on sustainable competitive performance, with digital culture playing a moderating role. Our findings reveal that managerial overconfidence significantly influences digital transformation and sustainable competitive performance in SMEs. Digital transformation serves as a significant mediator of the relationship between managerial overconfidence and sustainable competitive performance. Additionally, digital culture strengthens the association between managerial overconfidence and digital transformation. Based on these insights, SMEs need to be aware of managerial traits and, in particular, need to focus on overconfident managers to embrace digitalization and enhance performance.
Progression in low‐intensity ultrasound‐induced tumor radiosensitization
Authors: Xu Haonan , Liu Zichao , Du Meng , Chen Zhiyi 
Published: July 2024

AbstractBackgroundRadiotherapy (RT) is a widely utilized tumor treatment approach, while a significant obstacle in this treatment modality is the radioresistance exhibited by tumor cells. To enhance the effectiveness of RT, scientists have explored radiosensitization approaches, including the use of radiosensitizers and physical stimuli. Nevertheless, several approaches have exhibited disappointing results including adverse effects and limited efficacy. A safer and more effective method of radiosensitization involves low‐intensity ultrasound (LIUS), which selectively targets tumor tissue and enhances the efficacy of radiation therapy.MethodsThis review summarized the tumor radioresistance reasons and explored LIUS potential radiosensitization mechanisms. Moreover, it covered diverse LIUS application strategies in radiosensitization, including the use of LIUS alone, ultrasound‐targeted intravascular microbubble destruction, ultrasound‐mediated targeted radiosensitizers delivery, and sonodynamic therapy. Lastly, the review presented the limitations and prospects of employing LIUS‐RT combined therapy in clinical settings, emphasizing the need to connect research findings with practical applications.Results and ConclusionLIUS employs cost‐effective equipment to foster tumor radiosensitization, curtail radiation exposure, and elevate the quality of life for patients. This efficacy is attributed to LIUS's ability to utilize thermal, cavitation, and mechanical effects to overcome tumor cell resistance to RT. Multiple experimental analyses have underscored the effectiveness of LIUS in inducing tumor radiosensitization using diverse strategies. While initial studies have shown promising results, conducting more comprehensive clinical trials is crucial to confirm its safety and effectiveness in real‐world situations.
Synthesis and Semi‐Synthesis of Alpha‐Synuclein: Insight into the Chemical Complexity of Synucleinopathies
Authors: Gatzemeier Luisa Maria , Meyer Franc , Outeiro Tiago Fleming 
Published: July 2024

AbstractThe chemical rules governing protein folding have intrigued generations of researchers for decades. With the advent of artificial intelligence (AI), prediction of protein structure has improved tremendously. However, there is still a level of analysis that is only possible through wet laboratory experiments, especially in respect to the investigation of the pathological effect of mutations and posttranslational modifications (PTMs) on proteins of interest. This requires the availability of pure peptides and proteins in sufficient quantities for biophysical, biochemical, and functional studies. In this context, chemical protein synthesis and semi‐synthesis are powerful tools in protein research, which help to enlighten the role of protein modification in the physiology and pathology of proteins. A protein of high interest in the field of biomedicine is alpha‐synuclein (aSyn), a protein deeply associated with several devastating neurodegenerative disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), or multiple systems atrophy (MSA). Here, we describe several methods and pathways to synthesize native or modified aSyn, and discuss how these approaches enable us to address pathological mechanisms that may open novel perspectives for therapeutic intervention.
Targeting New Functions and Applications of Bacterial Two‐Component Systems
Authors: Ji Shixia , Li Conggang , Liu Maili , Liu Yixiang , Jiang Ling 
Published: July 2024

AbstractTwo‐component signal transduction systems (TCSs) are regulatory systems widely distributed in eubacteria, archaea, and a few eukaryotic organisms, but not in mammalian cells. A typical TCS consists of a histidine kinase and a response regulator protein. Functional and mechanistic studies on different TCSs have greatly advanced the understanding of cellular phosphotransfer signal transduction mechanisms. In this concept paper, we focus on the His‐Asp phosphotransfer mechanism, the ATP synthesis function, antimicrobial drug design, cellular biosensors design, and protein allostery mechanisms based on recent TCS investigations to inspire new applications and future research perspectives.
A Dual Bispecific Hydrolysis Peptide‐Drug Conjugate Responsive to Micro‐Acidic and Reduction Circumstance Promotes Antitumor Efficacy in Triple‐Negative Breast Cancer
Authors: Tang Tingting , Liu Naiyu , Wang Lingjuan , Zuo Kaiyue , Zhu Xinjie 
Published: July 2024

AbstractPaclitaxel and its derivates are the first‐line chemotherapeutic agents of breast cancer, which also showed tremendous clinical value in many other diseases including ovarian cancer, lung cancer etc. However, there are many drawbacks for almost all paclitaxel or its derivates, including extremely short half‐life, poor solubility and adverse events, which significantly limits their clinical applications. In this work, we designed and constructed a bispecific hydrolysis PAP‐SS‐PTX (term as PDC), consisting with pro‐apoptosis peptide (PAP) and paclitaxel (PTX) that were conjugated together via disulfide and ester bonds. On the one hand, PAP could improve the solubility of PTX and promote cellular uptake for drugs. On the other hand, it was able to prolong the PTX half‐life. We performed series of chemo‐dynamical assays and showed that PDC would release active drug molecules under micro‐acidic and reduction circumstance. The further assays elucidated that PDC could interrupt DNA synthesis and arrest cell division through downregulating CDK4/6 and Histone methylation that inhibit tumor growth in vitro. What's more, it could not only inhibit 4T1 breast tumor growth, but also prolong the survival time of mice and exert antitumor efficacy in vivo. It may provide a new research idea for cancer therapies via controlled release strategy in tumor microenvironment.
Evaluation of the Stereochemistry of Staphyloferrin A for Developing Staphylococcus‐Specific Targeting Conjugates
Authors: Wang Tsung‐Shing Andrew , Chen Pin‐Lung , Chen Yi‐Chen Sarah , Chiu Yu‐Wei , Lin Zih‐Jheng , Kao Chih‐Yao , Hung Hsuan‐Min 
Published: July 2024

AbstractBacteria in the genus Staphylococcus are pathogenic and harmful to humans. Alarmingly, some Staphylococcus, such as methicillin‐resistant S. aureus (MRSA) and vancomycin‐resistant S. aureus (VRSA) have spread worldwide and become notoriously resistant to antibiotics, threatening and concerning public health. Hence, the development of new Staphylococcus‐targeting diagnostic and therapeutic agents is urgent. Here, we chose the S. aureus‐secreted siderophore staphyloferrin A (SA) as a guiding unit. We developed a series of Staphyloferrin A conjugates (SA conjugates) and showed the specific targeting ability to Staphylococcus bacteria. Furthermore, among the structural factors we evaluated, the stereo‐chemistry of the amino acid backbone of SA conjugates is essential to efficiently target Staphylococci. Finally, we demonstrated that fluorescent Staphyloferrin A probes (SA‐FL probes) could specifically target Staphylococci in complex bacterial mixtures.
Coincidence or association: Adult‐onset Still's disease following HPV vaccine
Authors: Ahmed Muhammad , Husain Kaab , Husain Arqam , Syed Sameer , Haque Mahfujul Z. , Meysami Alireza 
Published: July 2024

Key Clinical MessageThis case details adult‐onset Still's disease (AOSD) onset post‐human papillomavirus (HPV) vaccination and acute gastroenteritis. The timing of HPV vaccine and vaccine‐autoimmune disease literature may potentially confound the well‐established link between infections and AOSD onset.
Bismuth‐based metal‐organic frameworks and derivatives for photocatalytic applications in energy and environment: Advances and challenges
Authors: Wang Yankun , Sun He , Yang Zhuxian , Zhu Yanqiu , Xia Yongde 
Published: July 2024

AbstractPhotocatalysis is an environmentally friendly technology for the utilizations of solar energy and has garnered significant attention in both scientific and industrial sectors. Developing cost‐effective semiconductive materials is the core issue in photocatalysis. Bismuth‐based metal‐organic frameworks (Bi‐MOFs) have emerged as attractive candidates in various photocatalytic applications, and Bi‐MOFs derivatives further expand and consolidate their promising potential in the realm of photocatalysis. Various modification strategies including in‐situ tailoring or external doping, as well as meticulous design and selection of metal nodes and organic linkers allow for fine control over the surface multifunctionality in Bi‐MOF‐based and derived photocatalytic composites with adjustable energy band structures and enhanced photocatalytic performance. In this review, the recent progress in the synthesis of diverse Bi‐MOFs‐based materials, Bi‐MOFs derivatives, and their Bi‐containing semiconductive composites were systemically analyzed and reviewed. The state‐of‐the‐art research progresses in the applications of Bi‐MOFs and derivatives, as well as composites in photocatalytic water splitting for hydrogen production, photodegradation of organic pollutants, and photocatalytic carbon dioxide reduction are comprehensively summarized. The relationships between structures, properties, and photocatalytic performance of Bi‐based semiconductive composites are discussed in detail. In addition, the perspectives and future challenges on Bi‐MOFs‐based and derived materials for photocatalytic applications are also offered.
Skull base plasmacytoma in young patients aged below 40 years: Radiological perspectives and clinical outcomes
Authors: Elsabah Hesham , Ghasoub Rola , Soliman Dina S. , Ibrahim Feryal , Aldapt Mahmood B. , Taha Ruba Y. , Al Azawi Safaa , Mudawi Deena , Moustafa Abbas , Elomri Halima , Cherif Honar 
Published: July 2024

AbstractBackgroundPlasmacytoma of the skull base is a rare manifestation of plasma cell neoplasm with only a few cases documented in literature involving young adults. Plasmacytoma can be an isolated solitary lesion or a secondary manifestation of multiple myeloma (MM). In this study, we report the clinical and radiological characteristics, management, and outcomes of patients under the age of 40 who presented with skull base plasmacytoma and associated neurological manifestations. Additionally, we share our experience in treating a rare case of skull base plasmacytoma diagnosed during pregnancy, in which the patient exhibited a favorable response to myeloma treatment initiated after delivery.Case SeriesFour patients were identified, comprising one pregnant female and three male patients, with a median age of 36 years (range 33–37 years). The main presenting symptoms were headache, dizziness, and cranial nerve palsy. All patients received underwent systemic myeloma therapy and radiotherapy with three patients also underwent autologous stem cell transplantation (ASCT). Notably, all patients achieved complete remission.ConclusionSkull base plasmacytoma represents a rare manifestation of plasma cell neoplasms, underscoring the importance of considering it in the differential diagnosis of skull base lesions to ensure early intervention and avoid potential serious complications. Throughout our series, the cornerstone of therapy involved radiotherapy, systemic myeloma therapy, and ASCT, all of which elicited a favorable response in every case.