bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of climate geoengineering appraisals
Authors: Bellamy Rob , Chilvers Jason , Vaughan Naomi E. , Lenton Timothy M. 
Published: October 2012

AbstractDeliberate large‐scale interventions in the Earth's climate system—known collectively as ‘geoengineering’—have been proposed in order to moderate anthropogenic climate change. Amidst a backdrop of many ways of framing the supposed normative rationales for or against their use, geoengineering proposals are undergoing serious consideration. To support decision makers in the multitude of governance considerations a growing number of appraisals are being conducted to evaluate their pros and cons. Appraisals of geoengineering are critically reviewed here for the first time using a systematic literature search and screen strategy. Substantial variability between different appraisals' outputs originates from usually hidden framing effects relating to contextual and methodological choices. Geoengineering has largely been appraised in contextual isolation, ignoring the wider portfolio of options for tackling climate change—spanning mitigation and adaptation—and creating an artificial choice between geoengineering proposals. Most existing appraisal methods do not adequately respond to the post‐normal scientific context in which geoengineering resides and show a strong emphasis on closed and exclusive ‘expert‐analytic’ techniques. These and other framing effects invariably focus—or close down—upon particular sets of problem definition, values, assumptions, and courses of action. This produces a limited range of decision options which seem preferable given those framing effects that are privileged, and could ultimately contribute to the closing down of governance commitments. Emergent closure around particular geoengineering proposals is identified and argued to be premature given the need for more anticipatory, responsible, and reflexive forms of governing what is an ‘upstream’ domain of scientific and technological development.WIREs Clim Change2012, 3:597–615. doi: 10.1002/wcc.197This article is categorized under:Social Status of Climate Change Knowledge > Climate Science and Decision Making
Turbo equalization of doubly selective channels
Authors: Barhumi Imad 
Published: October 2012

ABSTRACTIn this paper, turbo equalization for transmission over doubly selective channels is proposed. The maximum a posteriori probability (MAP) algorithm is used for channel detection as well as for channel decoding. The detection/decoding constituents can exchange soft information in an iterative manner resulting in the so‐called turbo equalization. The time‐varying multi‐path fading channel is modeled using the basis expansion model (BEM). In this BEM, the time‐varying channel is viewed as a bank of time‐invariant finite impulse response filters, and the time variation is captured by means of time‐varying complex exponential basis functions. Therefore, the time‐varying transition tables that characterize the time‐varying channel can also follow a similar BEM. The complexity of the MAP channel detector is rather prohibitive for practical applications. This motivates the search for lower‐complexity soft‐output channel detectors. For this purpose, soft‐output linear minimum‐mean square error (LMMSE)‐based channel detectors are proposed for single carrier as well as for multi‐carrier systems. With the use of Gaussian approximation, expressions for the a posteriori and extrinsic log‐likelihood ratios have been derived. The performance of the proposed turbo equalization schemes are evaluated using numerical simulations. Copyright © 2012 John Wiley & Sons, Ltd.
Neural induction and early patterning in vertebrates
Authors: Ozair Mohammad Zeeshan , Kintner Chris , Brivanlou Ali H. 
Published: October 2012

AbstractIn vertebrates, the development of the nervous system is triggered by signals from a powerful ‘organizing’ region of the early embryo during gastrulation. This phenomenon—neural induction—was originally discovered and given conceptual definition by experimental embryologists working with amphibian embryos. Work on the molecular circuitry underlying neural induction, also in the same model system, demonstrated that elimination of ongoing transforming growth factor‐β (TGFβ) signaling in the ectoderm is the hallmark of anterior neural‐fate acquisition. This observation is the basis of the ‘default’ model of neural induction. Endogenous neural inducers are secreted proteins that act to inhibit TGFβ ligands in the dorsal ectoderm. In the ventral ectoderm, where the signaling ligands escape the inhibitors, a non‐neural fate is induced. Inhibition of the TGFβ pathway has now been demonstrated to be sufficient to directly induce neural fate in mammalian embryos as well as pluripotent mouse and human embryonic stem cells. Hence the molecular process that delineates neural from non‐neural ectoderm is conserved across a broad range of organisms in the evolutionary tree. The availability of embryonic stem cells from mouse, primates, and humans will facilitate further understanding of the role of signaling pathways and their downstream mediators in neural induction in vertebrate embryos. WIREs Dev Biol 2012, 2:479–498. doi: 10.1002/wdev.90This article is categorized under:

Signaling Pathways > Global Signaling Mechanisms
Early Embryonic Development > Gastrulation and Neurulation
Nervous System Development > Vertebrates: General Principles
Longitudinal comparisons of dietary patterns derived by cluster analysis in 7- to 13-year-old children
Authors: Northstone Kate , Smith Andrew D. A. C. , Newby P. K. , Emmett Pauline M. 
Published: October 2012

Little is known about changes in dietary patterns over time. The present study aims to derive dietary patterns using cluster analysis at three ages in children and track these patterns over time. In all, 3 d diet diaries were completed for children from the Avon Longitudinal Study of Parents and Children at 7, 10 and 13 years. Children were grouped based on the similarities between average weight consumed (g/d) of sixty-two food groups using k-means cluster analysis. A total of four clusters were obtained at each age, with very similar patterns being described at each time point: Processed (high consumption of processed foods, chips and soft drinks), Healthy (high consumption of high-fibre bread, fruit, vegetables and water), Traditional (high consumption of meat, potatoes and vegetables) and Packed Lunch (high consumption of white bread, sandwich fillings and snacks). The number of children remaining in the same cluster at different ages was reasonably high: 50 and 43 % of children in the Healthy and Processed clusters, respectively, at age 7 years were in the same clusters at age 13 years. Maternal education was the strongest predictor of remaining in the Healthy cluster at each time point – children whose mothers had the highest level of education were nine times more likely to remain in that cluster compared to those with the lowest. Cluster analysis provides a simple way of examining changes in dietary patterns over time, and similar underlying patterns of diet at two ages during late childhood, that persisted through to early adolescence.
The Australian fruit Illawarra plum (Podocarpus elatusEndl., Podocarpaceae) inhibits telomerase, increases histone deacetylase activity and decreases proliferation of colon cancer cells
Authors: Symonds Erin L. , Konczak Izabela , Fenech Michael 
Published: October 2012

Fruit antioxidants have many health benefits including prevention of cancer development. The native Australian bush fruit Illawarra plum (Podocarpus elatusEndl., Podocarpaceae) has a high content of anthocyanin-rich phenolics, with an antioxidant capacity at levels higher than most fruits. In the present study the molecular mechanisms of the anti-proliferative activity of Illawarra plum on colorectal cancer cells were investigated. Non-tumorigenic young adult mouse colonic (YAMC) cells and tumorigenic human colonic (HT-29) cells were treated with a polyphenolic-rich Illawarra plum extract (0–1000 μg/ml). Illawarra plum had anti-proliferative properties in only the cancer cells, with growth suppressed in a dose- and time-dependent manner. Treatment of HT-29 cells with Illawarra plum extract (500 μg/ml; 24 h) was also associated with a 2-fold increase in apoptosis, and a cell cycle delay in the S phase (P< 0·01). Assessment of biomarkers for DNA damage revealed that plum treatment caused a 93 % down-regulation of telomerase activity (P< 0·001) and a decrease in telomere length (up to 75 %;P< 0·01). Treatment with Illawarra plum extract also induced morphological alterations to HT-29 cells that were suggestive of induction of autophagy, as the formation of cytoplasmic vacuoles was observed in many cells. This could be induced by the increased (6-fold) histone deacetylase (HDAC) activity (P< 0·001) and the trend for increased expression of the class III HDAC sirtuin 1. The present study has shown that Illawarra plum extract is able to reduce the proliferation of colon cancer cells by altering the cell cycle, increasing apoptosis and possibly inducing autophagy. The active ingredients in Illawarra plum may provide an alternative chemoprevention strategy to conventional chemotherapy.
Manipulative parasites may not alter intermediate host distribution but still enhance their transmission: field evidence for increased vulnerability to definitive hosts and non-host predator avoidance
Authors: LAGRUE C. , GÜVENATAM A. , BOLLACHE L. 
Published: October 2012

SUMMARYBehavioural alterations induced by parasites in their intermediate hosts can spatially structure host populations, possibly resulting in enhanced trophic transmission to definitive hosts. However, such alterations may also increase intermediate host vulnerability to non-host predators. Parasite-induced behavioural alterations may thus vary between parasite species and depend on each parasite definitive host species. We studied the influence of infection with 2 acanthocephalan parasites (Echinorhynchus truttae and Polymorphus minutus) on the distribution of the amphipod Gammarus pulex in the field. Predator presence or absence and predator species, whether suitable definitive host or dead-end predator, had no effect on the micro-distribution of infected or uninfected G. pulex amphipods. Although neither parasite species seem to influence intermediate host distribution, E. truttae infected G. pulex were still significantly more vulnerable to predation by fish (Cottus gobio), the parasite's definitive hosts. In contrast, G. pulex infected with P. minutus, a bird acanthocephalan, did not suffer from increased predation by C. gobio, a predator unsuitable as host for P. minutus. These results suggest that effects of behavioural changes associated with parasite infections might not be detectable until intermediate hosts actually come in contact with predators. However, parasite-induced changes in host spatial distribution may still be adaptive if they drive hosts into areas of high transmission probabilities.
Fast Real-Time PCR assay for detection of Tetramicra brevifilum in cultured turbot
Authors: ALONSO MERCEDES , LAGO FÁTIMA C. , GÓMEZ-REINO MARÍA , FERNÁNDEZ JACOBO , MARTÍN IRIS , VIEITES JUAN M. , ESPIÑEIRA MONTSERRAT 
Published: October 2012

SUMMARYGlobal aquaculture production of turbot has rapidly increased worldwide in the last decade and it is expected to have even bigger growth in the next years due to new farms operating. The losses caused by pathogen infections have grown at the same time as the production of this species. Parasitological infections are among the main relevant pathologies associated with its culture and produce serious losses in aquaculture, reduce the growth rate in fish and may lead to unmarketable fish due to skeletal muscle abnormalities in cases with high intensity of infection. The microsporidian parasite Tetramicra brevifilum causes severe infections and generates major losses in farmed turbot. Infections are difficult to control due to spore longevity and its direct transmission. To facilitate the infection management, an effective tool for fast detection and identification of T. brevifilum is needed. This study provides a molecular methodology of fast Real-Time PCR for T. brevifilum detection to the aquaculture industry, useful for routine control of T. brevifilum at turbot farms. The method is characterized by its high specificity and sensitivity, and it can be applied to cultured turbot for parasite detection regardless of the life-cycle stage of the pathogen or the infection intensity.
Physical capability and the advantages and disadvantages of ageing: perceptions of older age by men and women in two British cohorts
Authors: PARSONS SAMANTHA , GALE CATHARINE R. , KUH DIANA , ELLIOTT JANE ,   THE HALCYON STUDY TEAM
Published: October 2012

ABSTRACTIn an increasingly ageing society, its older members are receiving considerable political and policy attention. However, much remains to be learnt about public perceptions ofolderage, particularly the views and experiences of older individuals themselves. Drawing on qualitative interviews carried out with members of two British cohorts (N = 60) who have reached the ‘third age’, this paper discusses perceptions of age, focusing particularly on how perceived advantages and disadvantages differ by respondents' self-reported physical capability. The interviews were carried out in 2010 as part of the HALCyon (Healthy Ageing across the Life Course) collaborative research programme. Findings suggest there is some difference in the way older people view aspects of ageing by capability and that although advantages are widely perceived, physical decline and associated health concerns were the overwhelming theme across the conversations. The article concludes by making tentative suggestions to inform the positive ageing agenda and its related policies.
Association of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness
Authors: Kurrikoff Triin , Lesch Klaus-Peter , Kiive Evelyn , Konstabel Kenn , Herterich Sabine , Veidebaum Toomas , Reif Andreas , Harro Jaanus 
Published: October 2012

AbstractA functional promoter polymorphism of the nitric oxide synthase 1 gene first exon 1f variable number tandem repeat (NOS1ex1f-VNTR) is associated with impulsivity and related psychopathology. Facets of impulsivity are strongly associated with personality traits; maladaptive impulsivity with neuroticism; and adaptive impulsivity with extraversion. Both high neuroticism and low extraversion predict anxiety and depressive symptoms. The aim of the present study was to evaluate the effect of theNOS1ex1f-VNTR genotype and possible interaction with environmental factors on personality, anxiety, and depressiveness in a population-representative sample. Short allele carriers had higher neuroticism and anxiety than individuals with the long/long (l/l) genotype. Male short/short homozygotes also had higher extraversion. In the face of environmental adversity, females with a short allele had higher scores of neuroticism, anxiety, and depressiveness compared to the l/l genotype. Males were more sensitive to environmental conditions when they had the l/l genotype and low extraversion. In conclusion, theNOS1ex1f-VNTR influences personality and emotional regulation dependent on gender and environment. Together with previous findings on the effect of theNOS1genotype on impulse control, these data suggest thatNOS1should be considered another plasticity gene, because its variants are associated with different coping strategies.
The implications of genotype–environment correlation for establishing causal processes in psychopathology
Authors: Jaffee Sara R. , Price Thomas S. 
Published: October 2012

AbstractThe significance of genotype–environment interplay is its focus on how causal factors, whether environmental or genetic, have their effects. It is difficult to establish causality in observational research because of the potential for reverse causation and confounding. Most environmental measures are heritable, which means that their effects on the risk for psychopathology are potentially confounded by genotype. In contrast, genetic influences on psychopathology may be mediated by their effect on environmental exposures. The existence of genetic influences on putative environmental risk factors offers both possibilities and pitfalls for research into environmental epidemiology. We use the example of parenting and its influence on childhood externalizing problems to review how genotype–environment correlations can be exploited to demonstrate causal processes in pyschopathology.
Interparental conflict, parent psychopathology, hostile parenting, and child antisocial behavior: Examining the role of maternal versus paternal influences using a novel genetically sensitive research design
Authors: Harold Gordon T. , Elam Kit K. , Lewis Gemma , Rice Frances , Thapar Anita 
Published: October 2012

AbstractPast research has linked interparental conflict, parent psychopathology, hostile parenting, and externalizing behavior problems in childhood. However, few studies have examined these relationships while simultaneously allowing the contribution of common genetic factors underlying associations between family- and parent-level variables on child psychopathology to be controlled. Using the attributes of a genetically sensitive in vitro fertilization research design, the present study examined associations among interparental conflict, parents' antisocial behavior problems, parents' anxiety symptoms, and hostile parenting on children's antisocial behavior problems among genetically related and genetically unrelated mother–child and father–child groupings. Path analyses revealed that for genetically related mothers, interparental conflict and maternal antisocial behavior indirectly influenced child antisocial behavior through mother-to-child hostility. For genetically unrelated mothers, effects were apparent only for maternal antisocial behavior on child antisocial behavior through mother-to-child hostility. For both genetically related and genetically unrelated fathers and children, interparental conflict and paternal antisocial behavior influenced child antisocial behavior through father-to-child hostility. Effects of parental anxiety symptoms on child antisocial behavior were apparent only for genetically related mothers and children. Results are discussed with respect to the relative role of passive genotype–environment correlation as a possible confounding factor underlying family process influences on childhood psychopathology.
Resilience and measured gene–environment interactions
Authors: Kim-Cohen Julia , Turkewitz Rebecca 
Published: October 2012

AbstractThe past decade has witnessed an exponential growth in studies that have attempted to identify the genetic polymporphisms that moderate the influence of environmental risks on mental disorders. What tends to be neglected in these Gene × Environment (G × E) interaction studies has been a focus on resilience, which refers to a dynamic pattern of positive adaptation despite the experience of a significant trauma or adversity. In this article, we argue that one step toward advancing the field of developmental psychopathology would be for G × E research to consider resilience instead of focusing almost exclusively on mental disorders. After providing an up-to-date summary on the expanding definitions and models of resilience, and the available evidence regarding measured G × E studies of childhood maltreatment, we discuss why resilience would be a worthwhile phenotype for studies of measured G × E. First, although G × E hypotheses require that there be an environmental risk (e-risk) involved in a causal process that leads to psychopathology, e-risks are typically not included in the diagnostic criteria for most psychiatric disorders. In contrast, resilience by definition includes an e-risk. Second, G × E hypotheses require that there is evidence of variability in response to an environmental stressor, and resilience often represents the positive end on this continuum of adaptation. Third, both resilience and G × E are best understood from a developmental perspective. Fourth, although resilient outcomes are not public health concerns, the types of adversities (e.g., childhood maltreatment, poverty, or exposure to natural disasters) that are often investigated in studies of resilience certainly are. Understanding how some individuals, perhaps because of their genetic makeup, are able to withstand such adversities can inform prevention and intervention efforts to improve mental health.
The gene in its natural habitat: The importance of gene–trait interactions
Authors: DeYoung Colin G. , Clark Rachel 
Published: October 2012

AbstractDespite the substantial heritability of nearly all psychological traits, it has been difficult to identify specific genetic variants that account for more than a tiny percentage of genetic variance in phenotypes. Common explanations for this “missing heritability” include massive polygenicity, rare variants, epigenetics, epistasis, and gene–environment interactions. Gene–trait (G × T) interaction is another concept useful for understanding the lack of obvious genetic main effects. Both genes and environments are distal contributors to human behavior, but the brain is the proximal driver of behavior. The effect of any single genetic variant is dependent on the configuration of the brain in which it is expressed. One method to begin studying how single genes interact with variations in the rest of the brain is to investigate G × T interactions. A psychological trait reflects a characteristic pattern of psychological function (and, therefore, of brain function), which has its origin in the cumulative effects of both the genome and the environment. A trait therefore describes variation in the broad organismic context in which any single gene operates. We describe the nature and significance of G × T interactions for understanding psychopathology and normal trait variation, which are illustrated with empirical examples.
Genomic structural variation in psychiatric disorders
Authors: Rucker James J. H. , McGuffin Peter 
Published: October 2012

AbstractCopy number variants (CNVs) are submicroscopic deletions and duplications of genomic material that were previously thought to be rare phenomena. They have now been robustly associated with a variety of disorders such as autism, schizophrenia, and attention-deficit/hyperactivity disorder through an emerging research base in affective disorders. A complex picture is emerging of a polygenic, heterogeneous model of disease, with CNVs conferring broad susceptibility to a variety of neurodevelopmental disorders, rather than specific disorders per se. Although the insights gleaned thus far only represent a small piece of a much larger puzzle, progress has been rapid and new technologies promise even more insights into these hitherto opaque brain disorders. We will discuss CNVs, the current state of evidence for their role in the pathogenesis of classical psychiatric disorders, and the application of such knowledge in clinical settings.
Lexical decision as an endophenotype for reading comprehension: An exploration of an association
Authors: Naples Adam , Katz Len , Grigorenko Elena L. 
Published: October 2012

AbstractBased on numerous suggestions in the literature, we evaluated lexical decision (LD) as a putative endophenotype for reading comprehension by investigating heritability estimates and segregation analyses parameter estimates for both of these phenotypes. Specifically, in a segregation analysis of a large sample of families, we established that there is little to no overlap between genes contributing to LD and reading comprehension and that the genetic mechanism behind LD derived from this analysis appears to be more complex than that for reading comprehension. We conclude that in our sample, LD is not a good candidate as an endophenotype for reading comprehension, despite previous suggestions from the literature. Based on this conclusion, we discuss the role and benefit of the endophenotype approach in studies of complex human cognitive functions.