bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggregation of egg white proteins with pulsed electric fields and thermal processes
Authors: Wu Li , Zhao Wei , Yang Ruijin , Yan Wenxu , Sun Qianyan 
Published: November 2015

AbstractBACKGROUNDPulsed electric field (PEF) processing is progressing towards application for liquid egg to ensure microbial safety. However, it usually causes protein aggregation, and the mechanism is still unclear. In this study, egg white protein was applied to investigate the changes in protein structure and mechanism of aggregates formation and a comparison was made with thermal treatment.RESULTSSoluble protein content decreased with the increase of turbidity after both treatments. Fluorescence intensity and free sulfhydryl content were increased after being treated at 70 °C for 4 min. Less‐remarkable changes of hydrophobicity were observed after PEF treatments (30 kV cm−1, 800 µs). Soluble and insoluble aggregates were observed by thermal treatment, and disulfide bonds were the main binding forces. The main components of insoluble aggregates formed by thermal treatment were ovotransferrin (30.58%), lysozyme (18.47%) and ovalbumin (14.20%). While only insoluble aggregates were detected during PEF processes, which consists of ovotransferrin (11.86%), lysozyme (21.11%) and ovalbumin (31.07%). Electrostatic interaction played a very important role in the aggregates formation.CONCLUSIONPEF had a minor impact on the structure of egg white protein. PEF had insignificant influence on heat‐sensitive protein, indicating that PEF has potential in processing food with high biological activity and heat sensitive properties. © 2015 Society of Chemical Industry
Functional outcome after Ivor Lewis esophagectomy for cancer
Authors: Deldycke Annelies , Van Daele Elke , Ceelen Wim , Van Nieuwenhove Yves , Pattyn Piet 
Published: November 2015

BackgroundLittle is known on functional outcome after Ivor Lewis esophagectomy (ILE) with intrathoracic anastomosis.MethodsPatients who underwent ILE were identified from a prospective database. Clinicopathological data were retrieved and compared with functional outcome data based on patient self‐assessment by a standard questionnaire. Predictive factors for selected functional complaints were identified with logistic regression analyses.ResultsThree hundred and twenty‐two patients (80.4% male, mean age 62 years) were studied. Indications for surgery were adenocarcinoma (62.4%), squamous cell carcinoma (28%), and HG Barrett dysplasia (7%). Preoperative chemoradiation (CRT) was administered to 42.5% of patients. Anastomotic leakage occurred in 5.6% and was associated with higher age and diabetes mellitus. Functional symptoms identified were reflux (39%), delayed gastric emptying (37%), dumping (21.4%), and anastomotic stenosis (16%). In the multivariate models, anastomotic stenosis was associated with smaller stapler diameter and presence of esophagitis. Postoperative reflux was associated with higher BMI, whereas dumping was predicted by female gender and age. The quality of life questionnaires revealed a good general health status in 82% of the patients.ConclusionsFunctional complaints after ILE consist of reflux, delayed gastric emptying, dumping, and dysphagia, and are affected by age, gender, BMI, diabetes mellitus, and stapler diameter. J. Surg. Oncol. 2016;113:24–28. © 2015 Wiley Periodicals, Inc.
Using Lean Thinking at an otorhinolaryngology outpatient clinic to improve quality of care
Authors: van Leijen‐Zeelenberg Janneke E. , Brunings Jan Wouter , Houkes Inge , van Raak Arno J. A. , Ruwaard Dirk , Vrijhoef Hubertus J. M. , Kremer Bernd 
Published: November 2015

Objectives/HypothesisAlthough Lean Thinking has led to considerable improvement in a variety of healthcare settings, its effects on otorhinolaryngology remain underexposed. This study reports on how the implementation of Lean Thinking at an otorhinolaryngology outpatient clinic has affected patient and provider satisfaction, waste reduction, and organizational culture.Study DesignProspective before‐and‐after design.MethodsThe 18‐month prospective before‐and‐after design used mixed methods for data collection and analysis. A survey was conducted to measure satisfaction among patients and providers. Semistructured interviews were conducted to evaluate the effect of Lean Thinking on waste and organizational culture.ResultsDuring the project, 69 issues were posted on the Lean board. Improvements were made on 36 inefficiency issues, not all concerning a specific type of waste. Employees reported considerable improvement in transportation, motion, and waiting. Patient satisfaction was high both at baseline and follow‐up and did not change significantly. The effects on provider satisfaction were slight; satisfaction with autonomy and participation decreased significantly, but satisfaction with communication increased significantly.ConclusionsThe implementation of Lean Thinking at an otorhinolaryngology outpatient clinic reduced waste and increased provider satisfaction with communication. Although patient satisfaction did not change significantly, it cannot be concluded that the intervention had no effect on perceived quality of care. Other approaches to measure patients' perceptions should be considered.Level of EvidenceNA Laryngoscope, 126:839–846, 2016
Endolymphatic hydrops in superior canal dehiscence and large vestibular aqueduct syndromes
Authors: Sone Michihiko , Yoshida Tadao , Morimoto Kyoko , Teranishi Masaaki , Nakashima Tsutomu , Naganawa Shinji 
Published: November 2015

Objectives/HypothesisPathologic third window lesions, such as superior semicircular canal dehiscence syndrome (SCDS) or large vestibular aqueduct syndrome (LVAS), cause several auditory and vestibular symptoms, which might affect perilymphatic pressure and induce endolymphatic hydrops (EH). In this study, the existence of EH in subjects with SCDS or LVAS was investigated using contrast‐enhanced magnetic resonance imaging (MRI).Study DesignCase series at university hospital.MethodsSeventeen ears from nine subjects who were diagnosed as having SCDS (five ears from three cases) or LVAS (12 ears from six cases) were studied. Ears were evaluated by 3‐T MRI performed 4 hours after intravenous injection of gadodiamide hydrate. Imaging data concerning the degree of EH in the cochlea and the vestibule were compared with clinical symptoms and hearing levels for all ears.ResultsAll ears showed air–bone gaps at low frequencies on pure tone audiometry. None of the subjects with SCDS had episodes of acute sensorineural hearing loss (SNHL) or vestibular symptoms, except for one patient who complained of head vibration induced by loud noise. Conversely, five of six subjects with LVAS had episodes of acute SNHL or vestibular symptoms. Four of five ears with SCDS showed severe EH in the cochlea, and two ears showed mild EH in the vestibule. All ears with LVAS showed mild to severe EH in both the cochlea and vestibule.ConclusionsThe present study demonstrated the existence of EH in ears with pathologic third window lesions, which might affect patients' auditory or vestibular symptoms.Level of Evidence4 Laryngoscope, 126:1446–1450, 2016
Comprehensive application of robotic retroauricular thyroidectomy: The evolution of robotic thyroidectomy
Authors: Byeon Hyung Kwon , Kim Da Hee , Chang Jae Won , Ban Myung Jin , Park Jae Hong , Kim Won Shik , Choi Eun Chang , Koh Yoon Woo 
Published: November 2015

Objectives/HypothesisAs an evolvement of the robotic application to the thyroidectomy, we sought to seek the potential role of robotic thyroidectomy with the retroauricular (RA) approach prior to future comparative study between RA and transaxillary thyroidectomy. This study aims to verify the surgical feasibility of robotic RA thyroidectomy.Study DesignCase series with planned data collection.MethodsA total of 87 patients who underwent robotic RA thyroidectomy for clinically suspicious papillary thyroid carcinoma or benign lesions from January 2013 to May 2014 were retrospectively reviewed and analyzed.ResultsAll robotic surgeries via RA approach were successfully performed, without any significant intraoperative complications or conversion to open surgery. Based on patient‐reported outcome questionnaires, all patients were satisfied with their postoperative surgical scars.ConclusionRobotic RA thyroidectomy is technically feasible and safe, with satisfactory cosmetic results for patients where indicated.Level of Evidence4. Laryngoscope, 126:1952–1957, 2016
Geographic trends in management of early‐stage laryngeal cancer
Authors: Mourad Moustafa , Dezube Aaron , Moshier Erin , Shin Edward 
Published: November 2015

Objectives/HypothesisThe goal of the study was to identify geographic trends in the primary treatment of early‐stage glottic cancer.Study DesignRetrospective analysis of the United States National Cancer Institute's Surveillance, Epidemiology, and End‐Results (SEER) database.MethodsUsing the most up‐to‐date November 2014 submission of the SEER database in addition to SEER‐18 data files, a cohort was created of stage I to II squamous cell glottic cancer from 2004 to 2012. The treatment groups (radiation and surgery) were compared with respect to several pretreatment covariates including age, race, gender, state where they received treatment, year of diagnosis, and American Joint Committee on Cancer (AJCC) stage.ResultsIn analyzing geographic trends, a statistically significant difference in treatment received by region and state was found (P < .0001.). When examining patient demographics, there was no statistically significant difference in treatment by age (P = .5206), AJCC stage (P = .4922), or year of diagnosis (P = .6593). There was a significant difference in racial distribution by treatment (P = .0038), with patients receiving surgery more likely to be black than patients receiving radiation (12% vs. 10%). In analyzing overall survival (OS), there was no significant difference in OS among the four US treatment regions (P = .2508).ConclusionsGeographic factors impact overall treatment of early‐stage glottic cancer. In addition, it was determined that race was a factor that correlated to differences in treatment modality. Finally, overall survival across the United States was determined to be significantly better in patients receiving radiation therapy.Level of Evidence4 Laryngoscope, 126:880–884, 2016
Long‐Term Durum Wheat‐Based Cropping Systems Result in the Rapid Saturation of Soil Carbon in the Mediterranean Semi‐arid Environment
Authors: Novara Agata , Poma Ignazio , Sarno Mauro , Venezia Giacomo , Gristina Luciano 
Published: November 2015

AbstractClimate, soil physical–chemical characteristics, land management, and carbon (C) input from crop residues greatly affect soil organic carbon (SOC) sequestration. According to the concept of SOC saturation, the ability of SOC to increase with C input decreases as SOC increases and approaches a SOC saturation level. In a 12‐year experiment, six semi‐arid cropping systems characterized by different rates of C input to soil were compared for ability to sequester SOC, SOC saturation level, and the time necessary to reach the SOC saturation level. SOC stocks, soil aggregate sizes, and C inputs were measured in durum wheat monocropping with (Ws) and without (W) return of aboveground residue to the soil and in the following cropping systems without return of aboveground residue to soil: durum wheat/fallow (Wfall), durum wheat/berseem clover, durum wheat/barley/faba bean, and durum wheat/Hedysarum coronarium. The C sequestration rate and SOC content were lowest in Wfall plots but did not differ among the other cropping systems. The C sequestration rate ranged from 0.47 Mg C ha−1 y−1 in Ws plots to 0.66 Mg C ha−1 y−1 in W plots but was negative (−0.06 Mg C ha−1 y−1) in Wfall plots. Increases in SOC were related to C input up to a SOC saturation value; over this value, further C inputs did not lead to SOC increase. Across all cropping systems, the C saturation value for the experimental soil was 57.7 Mg ha−1, which was reached with a cumulative C input of 15 Mg ha−1. Copyright © 2015 John Wiley & Sons, Ltd.
Volumetric changes in transplanted vascularized fat flaps after ischemic or congestive stresses and their relationship to capillary density in a zucker fatty rat model
Authors: Tanaka Kentaro , Okazaki Mutsumi , Yano Tomoyuki , Akiyama Masako , Mori Hiroki , Uemura Noriko 
Published: November 2015

BackgroundThe aim of this study was to examine volumetric changes in fat flaps after stresses as well as their relationship with capillary density (CD) in a Zucker fatty rat model.MethodsA total of 12 male Zucker‐fa/fa rats were randomly divided into two stress groups. Superficial epigastric fat flaps were evaluated on the right side as control and on the left side as the stress (ischemic or congestive) condition in the same rat in order to avoid biases. Stress conditions were made by obstructing the pedicle vessels with a vascular clip for 3 hours. The volumes of these flaps were measured weekly. After 12 weeks of measurements, the CD of harvested flaps was examined in histologically immunostained sections. Percent changes in the body‐weight‐corrected flap volume [cFV(%)], the stress/control ratio [FV‐ratio(%)], and the stress/control ratio of CD (CD‐ratio) were defined.ResultscFV(%) 12 weeks after surgery was 34.7 ± 26.7 in the control flaps and 13.2 ± 10.5 in the stress flaps. The FV‐ratio(%) after 12 weeks was 7.4–202.5 (70.2 ± 77.9) in the ischemic group and 14.6–66.3 (37.7 ± 22.2) in the congestive group. The difference in variance between two groups was significant (P = 0.030). cFV(%) correlated with total CD (P = 0.011). The FV‐ratio(%) correlated with the CD‐ratio (P = 0.002).ConclusionsWeekly measurements of flap volumes in the Zucker fatty rat model were new and useful methods. The FV‐ratio(%) in the congestive group decreased at a constant rate, while that in the ischemic group decreased or increased slightly. The rate of decreases in the flap volume correlated with CD. © 2015 Wiley Periodicals, Inc. Microsurgery 35:653–661, 2015.
Fast three‐dimensional inner volume excitations using parallel transmission and optimized k‐space trajectories
Authors: Davids Mathias , Schad Lothar R. , Wald Lawrence L. , Guérin Bastien 
Published: November 2015

PurposeTo design short parallel transmission (pTx) pulses for excitation of arbitrary three‐dimensional (3D) magnetization patterns.MethodsWe propose a joint optimization of the pTx radiofrequency (RF) and gradient waveforms for excitation of arbitrary 3D magnetization patterns. Our optimization of the gradient waveforms is based on the parameterization of k‐space trajectories (3D shells, stack‐of‐spirals, and cross) using a small number of shape parameters that are well‐suited for optimization. The resulting trajectories are smooth and sample k‐space efficiently with few turns while using the gradient system at maximum performance. Within each iteration of the k‐space trajectory optimization, we solve a small tip angle least‐squares RF pulse design problem. Our RF pulse optimization framework was evaluated both in Bloch simulations and experiments on a 7T scanner with eight transmit channels.ResultsUsing an optimized 3D cross (shells) trajectory, we were able to excite a cube shape (brain shape) with 3.4% (6.2%) normalized root‐mean‐square error in less than 5 ms using eight pTx channels and a clinical gradient system (Gmax = 40 mT/m, Smax = 150 T/m/s). This compared with 4.7% (41.2%) error for the unoptimized 3D cross (shells) trajectory. Incorporation of B0 robustness in the pulse design significantly altered the k‐space trajectory solutions.ConclusionOur joint gradient and RF optimization approach yields excellent excitation of 3D cube and brain shapes in less than 5 ms, which can be used for reduced field of view imaging and fat suppression in spectroscopy by excitation of the brain only. Magn Reson Med 76:1170–1182, 2016. © 2015 Wiley Periodicals, Inc.
Improving the arterial input function in dynamic contrast enhanced MRI by fitting the signal in the complex plane
Authors: Simonis Frank F.J. , Sbrizzi Alessandro , Beld Ellis , Lagendijk Jan J.W. , van den Berg Cornelis A.T. 
Published: November 2015

PurposeDynamic contrast enhanced (DCE) imaging is a widely used technique in oncologic imaging. An essential prerequisite for obtaining quantitative values from DCE‐MRI is the determination of the arterial input function (AIF). However, it is very challenging to accurately estimate the AIF using MR. A comprehensive model, which uses complex data instead of either magnitude or phase, was developed to improve AIF estimation.Theory and MethodsThe model was first applied to simulated data. Subsequently, the accuracy of the estimated contrast agent concentration was validated in a phantom. Finally the method was applied to existing DCE scans of 13 prostate cancer patients.ResultsThe complex signal method combines the complementary strengths of the magnitude and phase method, increasing the precision and accuracy of concentration estimation in simulated and phantom data. The in vivo AIFs show a good agreement between arterial voxels (standard deviation in the peak and tail equal 0.4 mM and 0.12 mM, respectively). Furthermore, the dynamic behavior closely followed the AIF obtained with DCE‐CT in the same patients (mean correlation coefficient: 0.92).ConclusionBy using the complex signal, the AIF estimation becomes more accurate and precise. This might enable patient specific AIFs, thereby improving the quantitative values obtained from DCE‐MRI. Magn Reson Med 76:1236–1245, 2016. © 2015 Wiley Periodicals, Inc.
What's In It for the Volunteers?
Authors: Classens Michael 
Published: November 2015

AbstractThis article reports on a social return on investment (SROI) analysis of volunteers of the Good Food Market program, a food access initiative run by FoodShare Toronto, one of Canada's largest food‐justice organizations. Unlike conventional SROI research, which typically focuses on the entire ecology of an organization or program, this article focuses solely on isolating the return volunteers receive on their investment of time, skills, energy, and the like—an SROI of volunteering. The article reviews the challenges of adapting the SROI methodology to the context of volunteer benefits and finds that ultimately SROI is a useful tool for articulating the value of volunteering.
An Arrowhead Injury in a Late Neolithic/Early Chalcolithic Human Cuneiform from the Rockshelter of La Peña de Marañón (Navarre, Spain)
Authors: Fernández‐Crespo T. 
Published: November 2015

AbstractThe current paper describes a projectile injury found among human remains recovered from La Peña de Marañón, a small natural rockshelter located in a limestone cliff hanging over the Ega River (Navarre, northern Spain), very close to other well‐known sites with similar evidence (San Juan ante Portam Latinam, Longar, Las Yurdinas II). The site was used as burial place during the Late Neolithic/Early Chalcolithic, and comprises a burnt bone assemblage of at least 28 individuals in a commingled state. In the process of re‐examining the anthropological collection a small fragment of flint was found embedded in a right lateral cuneiform. Both macroscopic and microscopic analysis and computer tomography confirm the presence of signs of healing. No other indications of trauma were observed in the human bone sample. The finding represents the first Spanish example of a prehistoric arrowhead wound on a foot and adds to the very few other archaeological case descriptions available in Europe. Copyright © 2015 John Wiley & Sons, Ltd.
Prenatal diagnosis of Bartter syndrome: amniotic fluid aldosterone
Authors: Rachid Myriam L. , Dreux Sophie , Pean de Ponfilly Gauthier , Vargas‐Poussou Rosa , Czerkiewicz Isabelle , Chevenne Didier , Oury Jean‐François , Deschênes Georges , Muller Françoise 
Published: November 2015

AbstractObjectiveBartter syndrome is a severe inherited tubulopathy characterized by postnatal salt wasting, severe polyuria, dehydration, failure to thrive and secondary hyperaldosteronism. Prenatally, the disease is usually discovered following the onset of severe polyhydramnios in the second trimester. We studied amniotic fluid aldosterone concentration in Bartter syndrome and in controls.MethodsAmniotic fluid aldosterone was assayed by radioimmunoassay. We undertook a retrospective case‐control study based on 36 cases of prenatally suspected and postnatally confirmed Bartter syndrome (22 with identified mutations): and 72 gestational age matched controls presenting with polyhydramnios and 72 without polyhydramnios. Amniotic fluid aldosterone was compared between the three groups.ResultsThe median amniotic fluid aldosterone concentration in the Bartter syndrome group (90 pg/mL) was not different from that in the controls with polyhydramnios (90 pg/mL, P = 0.33) or without polyhydramnios (87 pg/mL, P = 0.41).ConclusionAmniotic fluid aldosterone assay cannot be used for prenatal diagnosis of Bartter syndrome. © 2015 John Wiley & Sons, Ltd.
New materials from dimethacrylates bearing phosphonic acid and thioether groups
Authors: Kemnitz Melanie , Tabatabai Monir , Utterodt Andreas , Ritter Helmut 
Published: November 2015

AbstractA new series of crosslinkable dimethacrylates containing thioether and phosphonic acid were synthesized. The structures of the different synthesized crosslinkable agents based on oleic acid, cinnamic acid, acrylated glycerol 1,3‐dimethacrylate and a chalcone derivative were established by electrospray ionization, DSC, NMR and Fourier transform infrared spectroscopy. In order to prove the accessability of the double bonds on network formation, the radical curing of these compounds with N,N‐dimethylacrylamide as comonomer was examined. © 2015 Society of Chemical Industry
Factors associated with psychological distress in women with breast cancer‐related lymphoedema
Authors: Alcorso Jessica , Sherman Kerry A. 
Published: November 2015

AbstractBackgroundPrevious research has shown that lymphoedema impacts negatively on an individual, including psychological distress and body image disturbance, particularly for younger women. This study identified psychological factors associated with distress in women with breast cancer‐related lymphoedema and determined whether age moderated the specific relationship between body image disturbance and distress.MethodsAustralian women (n = 166) diagnosed with breast cancer‐related lymphoedema were recruited through a community‐based breast cancer organisation and lymphoedema treatment clinics. Participants completed an online survey assessing lymphoedema‐related cognitions (personal control, perceived treatment effectiveness, and consequences of lymphoedema), perceived ability to self‐regulate lymphoedema‐related negative affect, body image disturbance, psychological distress (depression, anxiety and stress), and demographic/medical information.ResultsBeliefs about the consequences, perceived effectiveness of treatment and controllability of lymphoedema, perceived ability to self‐regulate negative affect, body image disturbance, and number of lymphoedema symptoms were correlated with depression, anxiety, and stress scores. Multivariate regression analyses indicated that body image disturbance was significantly associated with depression, anxiety, and stress, and perceived treatment effectiveness was associated with stress. Age was a significant moderator of the relationship between body image disturbance and depression and anxiety, with older women with greater body image disturbance more distressed.ConclusionsHealth professionals need to be aware that women diagnosed with lymphoedema are at risk of experiencing psychological distress, particularly arising from body image disturbance and beliefs that treatment cannot control lymphoedema. Furthermore, older women may be at an increased risk of anxiety and depression arising from body image disturbance. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.