bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting YES1 Disrupts Mitotic Fidelity and Potentiates the Response to Taxanes in Triple-Negative Breast Cancer
Authors: Piemonte Katrina M. , Ingles Natasha N. , Weber-Bonk Kristen L. , Valentine Mitchell J. , Majmudar Parth R. , Singh Salendra , Keri Ruth A. 
Published: July 2024

Abstract
Clinical trials examining broad-spectrum Src family kinase (SFK) inhibitors revealed significant dose-limiting toxicities, preventing advancement for solid tumors. SFKs are functionally heterogeneous, thus targeting individual members is a potential strategy to elicit antitumor efficacy while avoiding toxicity. Here, we identified that YES1 is the most highly overexpressed SFK in triple-negative breast cancer (TNBC) and is associated with poor patient outcomes. Disrupting YES1, genetically or pharmacologically, induced aberrant mitosis, centrosome amplification, multipolar spindles, and chromosomal instability. Mechanistically, YES1 sustained FOXM1 protein levels and elevated expression of FOXM1 target genes that control centrosome function and are essential for effective and accurate mitotic progression. In both in vitro and in vivo TNBC models, YES1 suppression potentiated the efficacy of taxanes, cornerstone drugs for TNBC that require elevated chromosomal instability for efficacy. Clinically, elevated expression of YES1 was associated with worse overall survival of patients with TNBC treated with taxane and anthracycline combination regimens. Together, this study demonstrates that YES1 is an essential regulator of genome stability in TNBC that can be leveraged to improve taxane efficacy.
Significance: YES1 is a sentinel regulator of genomic maintenance that controls centrosome homeostasis and chromosome stability through FOXM1, revealing this pathway as a therapeutic vulnerability for enhancing taxane efficacy in triple-negative breast cancer.
FANCI Inhibition Induces PARP1 Redistribution to Enhance the Efficacy of PARP Inhibitors in Breast Cancer
Authors: Huang Yu-Zhou , Sang Ming-Yi , Xi Pei-Wen , Xu Ruo-Xi , Cai Meng-Yuan , Wang Zi-Wen , Zhao Jian-Yi , Li Yi-Han , Wei Ji-Fu , Ding Qiang 
Published: July 2024

Abstract
Breast cancer is a global public health concern with high mortality rates, necessitating the development of innovative treatment strategies. PARP inhibitors have shown efficacy in certain patient populations, but their application is largely limited to cancers with homologous recombination deficiency. Here, we identified the suppression of FANCI as a therapeutic strategy to enhance the efficacy of PARP inhibitors in breast cancer. Elevated FANCI expression in breast cancer was associated with poor prognosis and increased cell proliferation and migration. FANCI interacted with PARP1, and suppressing FANCI limited the nuclear localization and functionality of PARP1. Importantly, FANCI inhibition sensitized breast cancer cells to the PARP inhibitor talazoparib in the absence of BRCA mutations. Additionally, the CDK4/6 inhibitor palbociclib enhanced the sensitivity of breast cancer cells to talazoparib through FANCI inhibition. These findings highlight the potential of targeting FANCI to enhance the efficacy of PARP inhibitors in treating breast cancer.
Significance: Targeting FANCI is a promising therapeutic strategy for enhancing PARP inhibitor sensitivity in breast cancer that holds potential for broader therapeutic applications beyond cancers harboring BRCA mutations.
Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis
Authors: Bermejo-Rodriguez Camino , Araos Henríquez Joaquín , Caligiuri Giuseppina , Pinto Teles Sara , Park Youngkyu , Evans Anthony , Barrera Lawrence N. , Neesse Albrecht , Grützmann Robert , Aust Daniela , Rümmele Petra , Knösel Thomas , Narita Masako , Narita Masashi , Campbell Fiona , Öhlund Daniel , Pilarsky Christian , Dow Lukas E. , Humbert Patrick O. , Biffi Giulia , Tuveson David A. , Perez-Mancera Pedro A. 
Published: July 2024

Abstract
Perturbation of cell polarity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) progression. Scribble (SCRIB) is a well-characterized polarity regulator that has diverse roles in the pathogenesis of human neoplasms. To investigate the impact of SCRIB deficiency in PDAC development and progression, Scrib expression was genetically ablated in well-established mouse models of PDAC. Scrib loss in combination with KrasG12D did not influence development of pancreatic intraepithelial neoplasms in mice. However, Scrib deletion cooperated with KrasG12D and concomitant Trp53 heterozygous deletion to promote invasive PDAC and metastatic dissemination, leading to reduced overall survival. Immunohistochemical and transcriptome analyses revealed that Scrib-null tumors display a pronounced reduction of collagen content and an abundance of cancer-associated fibroblasts (CAF). Mechanistically, IL1α levels were reduced in Scrib-deficient tumors, and Scrib knockdown downregulated IL1α in mouse PDAC organoids (mPDO), which impaired CAF activation. Furthermore, Scrib loss increased YAP activation in mPDOs and established PDAC cell lines, enhancing cell survival. Clinically, SCRIB expression was decreased in human PDAC, and SCRIB mislocalization was associated with poorer patient outcome. These results indicate that SCRIB deficiency enhances cancer cell survival and remodels the tumor microenvironment to accelerate PDAC development and progression, establishing the tumor suppressor function of SCRIB in advanced pancreatic cancer.
Significance: SCRIB loss promotes invasive pancreatic cancer development via both cell-autonomous and non–cell-autonomous processes and is associated with poorer outcomes, denoting SCRIB as a tumor suppressor and potential biomarker for the prediction of recurrence.
XCP-D: A robust pipeline for the post-processing of fMRI data
Authors: Mehta Kahini , Salo Taylor , Madison Thomas J. , Adebimpe Azeez , Bassett Danielle S. , Bertolero Max , Cieslak Matthew , Covitz Sydney , Houghton Audrey , Keller Arielle S. , Lundquist Jacob T. , Luo Audrey , Miranda-Dominguez Oscar , Nelson Steve M. , Shafiei Golia , Shanmugan Sheila , Shinohara Russell T. , Smyser Christopher D. , Sydnor Valerie J. , Weldon Kimberly B. , Feczko Eric , Fair Damien A. , Satterthwaite Theodore D. 
Published: July 2024

Abstract
Functional neuroimaging is an essential tool for neuroscience research. Pre-processing pipelines produce standardized, minimally pre-processed data to support a range of potential analyses. However, post-processing is not similarly standardized. While several options for post-processing exist, they may not support output from different pre-processing pipelines, may have limited documentation, and may not follow generally accepted data organization standards (e.g., Brain Imaging Data Structure (BIDS)). In response, we present XCP-D: a collaborative effort between PennLINC at the University of Pennsylvania and the DCAN lab at the University of Minnesota. XCP-D uses an open development model on GitHub and incorporates continuous integration testing; it is distributed as a Docker container or Apptainer image. XCP-D generates denoised BOLD images and functional derivatives from resting-state data in either NIfTI or CIFTI files following pre-processing with fMRIPrep, HCP, or ABCD-BIDS pipelines. Even prior to its official release, XCP-D has been downloaded &gt;5,000 times from DockerHub. Together, XCP-D facilitates robust, scalable, and reproducible post-processing of fMRI data.
Connectivity of Fronto-Temporal Regions in Syntactic Structure Building During Speaking and Listening
Authors: Giglio Laura , Sharoh Daniel , Ostarek Markus , Hagoort Peter 
Published: July 2024

Abstract
The neural infrastructure for sentence production and comprehension has been found to be mostly shared. The same regions are engaged during speaking and listening, with some differences in how strongly they activate depending on modality. In this study, we investigated how modality affects the connectivity between regions previously found to be involved in syntactic processing across modalities. We determined how constituent size and modality affected the connectivity of the pars triangularis of the left inferior frontal gyrus (LIFG) and of the left posterior temporal lobe (LPTL) with the pars opercularis of the LIFG, the left anterior temporal lobe (LATL), and the rest of the brain. We found that constituent size reliably increased the connectivity across these frontal and temporal ROIs. Connectivity between the two LIFG regions and the LPTL was enhanced as a function of constituent size in both modalities, and it was upregulated in production possibly because of linearization and motor planning in the frontal cortex. The connectivity of both ROIs with the LATL was lower and only enhanced for larger constituent sizes, suggesting a contributing role of the LATL in sentence processing in both modalities. These results thus show that the connectivity among fronto-temporal regions is upregulated for syntactic structure building in both sentence production and comprehension, providing further evidence for accounts of shared neural resources for sentence-level processing across modalities.
Telemedicine in Acute Trauma Care: A Review of Quantitative Evaluations on the Impact of Remote Consultation
Authors: Patel Prem , Aucar John 
Published: July 2024

Background There is extensive literature describing the application of telemedicine techniques to trauma care. However, there is a paucity of articles showing quantitative assessment of its safety and efficacy. This structured review examines articles with quantitative assessment of telemedicine’s impact in acute trauma care. Methods Medline and CINAHL databases were searched for peer-reviewed articles that quantitatively assess the impact of telemedicine on diagnostic accuracy, clinical decision-making, emergency department length of stay, transfer rates, and mortality in initial trauma management. Results Only 9 of the 408 screened articles met the criteria for quantitative assessment. Telemedicine appears to be preferentially used for more severely injured patients. Limited quality evidence supports procedural interventions at remote sites. Telemedicine may help abbreviate pre-transfer length of stay. However, its impact on diagnosis and mortality remains unclear. Conclusions Telemedicine’s potential to enhance the quality and efficiency of trauma care, especially for resource-scarce areas, warrants continued quantitative research.
EXCOR membrane motion analyzer (EMMA) to quantify and assess hemodynamic performance of the EXCOR pediatric heart assist device
Authors: Hillner Rachel , Perry Luke , Hill Natalie , Badheka Aditya V , Chivukula Venkat Keshav 
Published: July 2024

Background Pediatric heart failure is associated with high mortality rates and is a current clinical burden. There is only one FDA approved pediatric VAD, Berlin Heart EXCOR, for treatment. Thrombo-embolic complications are a significant clinical challenge, which can lead to devastating complications such as stroke and impair efficient EXCOR function. Currently, clinicians perform largely qualitative periodic assessment of EXCOR operation by observing the motion of a rapidly moving membrane, which can be prone to human error and can lead to missing out on crucial information. Methods In this study, we design and implement a quantitative early warning system for accurate and quantitative assessment of the EXCOR membrane, named EXCOR Membrane Motion Analyzer (EMMA). Using a combination of image analysis, computer vision and custom designed algorithm, we perform rigorous frame by frame analysis of EXCOR membrane video data. We developed specialized metrics to identify relative smoothness between successive peaks, time between peaks and overall smoothness indicators to quantify and compare between multiple cases. Results Our results demonstrate that EMMA can successfully identify the motion and wrinkles on each video frame and quantify the smoothness and identify the phases of each cardiac cycle. Moreover, EMMA can obtain the smoothness of each frame and the temporal evolution of membrane smoothness across all image frames for the video sequence. Conclusions EMMA allows for a fast, accurate, quantitative assessment to be completed and reduces user error. This enables EMMA to be used effectively as an early warning system to rapidly identify device abnormalities.
Development and Psychometric Evaluation of the Social Participation Questionnaire: A Methodological and Cross-Sectional Study
Authors: Zhao Di , Li Guopeng , Qin Rui , Zhao Xiangyu , Qi Meiling , Ma Qinghua , Li Ping 
Published: July 2024

Purpose Social participation is vital for the health maintenance of general populations as well as the functional recovery and social ties of clinical patients. To develop a Social Participation Questionnaire (SPQ) to evaluate participation in social activities in an individual’s life and to test the reliability and validity of the SPQ. Design Cross-sectional study. Setting Community and clinic in China. Subjects A total of 1419 healthy adults and 486 breast cancer patients. Measures The initial items were developed from a theoretical framework, a literature review, and Delphi expert consultation. Item analysis, exploratory (EFA) and confirmatory factor analysis (CFA), criterion validity, construct reliability, and internal consistency reliability were performed to examine the psychometric properties of the SPQ. Results The final SPQ was comprised of 11 different types of social activities, falling under the 3 dimensions of activities of daily life, sports and entertainment activities, and social service activities. EFA explained 50.674% of the total item variance contributing to the tool. CFA showed that the SPQ fit well. The total SPQ score was significantly associated with social network, quality of life, and cognitive function ( r = |.180∼.466|, P < .001). The internal consistency coefficient was acceptable (range of Cronbach’s alpha, .695 to .720). Conclusions The SPQ has robust properties, wide application, and provides a culturally relevant tool to evaluate the social participation of individuals, thus facilitating rigorous clinical and population-based research.
Understanding Factors that Influence Parents’ Provision of Beverages to Their Children: A Qualitative Evidence Synthesis
Authors: Vallone Natalie , Drake Morgan , Dawer Adam , Brill Rachel , Sylvetsky Allison C. 
Published: July 2024

Objective Understand parental perceptions of beverages and factors influencing the beverage choices they make for their children. Data Source A literature search was conducted using PubMed, Scopus, and CINAHL. Study Inclusion and Exclusion Criteria Included studies contained qualitative data examining parents’ perceptions of beverages or factors that influence their child’s beverage consumption, were conducted in the United States between 2000 and 2022, written in English, and enrolled parents of children aged 18 years or younger. Data Extraction Authors, titles, study aims, methods, qualitative results, and representative quotations were extracted using Covidence. Data Synthesis Qualitative findings were independently coded by two coders. Codes were compared and discrepancies resolved through discussion with a third team member. Themes and sub-themes were identified, and representative quotations selected. Results 13 studies met inclusion criteria. Five major themes emerged: 1) factors that influence parents’ provision of beverages to their children, 2) parents’ concerns about sugar-sweetened beverages (SSBs), 3) barriers to limiting children’s SSB consumption, 4) strategies to lower children’s SSB consumption, and 5) parents’ perceptions of beverage healthfulness. Conclusion Though most parents are aware of unfavorable health effects of frequent SSB intake, environmental and sociocultural factors pose barriers to limiting their child’s SSB consumption. Changes to policy and the food environment are needed to initiate and sustain reductions in SSB intake, along with continued nutrition education efforts.
Primary care team reorganisation after the SARS-COV-2 pandemic. Differences between Catalonia and Spain in the PRICOV study
Authors: Peris Grao Antoni , Freixenet Núria , Mora Toni , Roche David 
Published: July 2024

Background Spanish primary care services are managed differently by each region’s authorities. Catalonia started its services provision and design nearly two decades before other Spanish regions and developed nurses’ roles and task shifting in primary care. Purpose This work identifies differences in the Europe PRICOV-19 study answers between Catalonia and those submitted from the rest of Spain regarding how primary care teams (PCT) were organised during the SARS-CoV-2-2019 pandemic, how tasks and roles changed, and the pandemic’s impact on the care providers. Initially, we computed bivariate relationships and tested using contingency association and unpaired Wilcoxon. Analysis Still, we estimated multiple linear regressions controlling with a list of individual and GP practice characteristics and clustering standard errors at the kind of location. Results Main statistically significant differences were found in the adaptation to the new tasks, the ability to solve most health problems, and specific accessibilities to primary care. In Catalonia, satisfaction with the adaptation to the new tasks was higher (41.9% satisfied and 30.2% neutral) than in the rest of Spain (50.9% dissatisfaction). Also, GPs in Catalonia reported to a greater extent than the rest of Spain that chronic patients were listed for extensive follow-up. These differences may be related to Catalonia’s strategy for empowering primary care professionals other than family doctors. Conclusions Considering future pandemics, demographic ageing, and professional shortages, we point out the potential benefits of these changes in PCT organisations and the need to review the centres’s design.
Factors that Influence Growth Rates of Abdominal Aortic Aneurysms. Analysis of a Mexican Cohort
Authors: Bobadilla-Rosado Luis O. , Anaya-Ayala Javier E. , Santos-Chavez Eros , Navarro Julio , Martinez-Quesada Ignacio , Laparra-Escareno Hugo , Mendez-Dominguez Nina , Hinojosa Carlos A. 
Published: July 2024

Objective Abdominal Aortic Aneurysms (AAA) growth remains a process not fully understood. The objective of this study was to analyze risk factors associated with changes in AAA diameter in a Mexican cohort. Methods An observational study in which we analyzed the entirely of patients in which an AAA was reported in a Computed Tomography (CT) study from 2014 to 2021 who had a follow-up CT. We divided them by groups depending on the diagnosis of type 2 diabetic mellitus and pharmacological history (diabetic vs non-diabetic, metformin vs non-metformin intake and statin vs non-statin intake). We compared pre and post follow-up AAA diameters using paired t-tests. A multivariate analysis was performed in order to identify independent variables associated with an increased growth rate. Statistical analysis was performed on Stata 17. Results During the studied period 72 (39.77%) patients had a follow-up CT. Mean age was 75 years (±9.05) and 52 (72.22%) were men. When comparing infra-renal largest diameter through time based on metformin intake, a significant difference was found only in the metformin non-intake group (42.05 ± 12.54 vs45.34 ± 12.06 [ P = 0.02]), in contrast the metformin intake group measures were non-significantly different (36.13 ± 7.04 vs 37.00 ± 4.51; P = 0.57) through follow-up. In the multivariate analysis AAA largest diameter at diagnosis correlated with significantly increased growth rate (coeff = 0.06, P < 0.05). Conclusions AAA diameters appear to change through time in a non-linear pattern influenced by different epidemiological and clinical factors. Metformin intake appears to promote a stability in AAA diameter growth in our studied population.
Nationwide analysis of EVAR explantation outcomes in Korea: A comprehensive dataset study
Authors: Kim Hyo Kee , Park Pyoung Jae , Park Jee Hyun , Oh Young Ju , Jung Cheol Woong , Jun Heungman 
Published: July 2024

Objective Endovascular aortic aneurysm repair (EVAR) is the primary treatment for abdominal aortic aneurysms, constituting 70%–80% of interventions. Despite initial benefits, long-term studies show increased mortality. Using nationwide data, this study assesses outcomes of EVAR, open aortic repair (OAR), and EVAR explantation (EE) in Korea, while exploring characteristics of late open conversion, including the rising EE incidence. Methods Employing the National Health Insurance Service database, covering health-related data for nearly 50 million Koreans, the study spanned from 2002 to 2020. Patients with AAA diagnoses (I71.3 or I71.4) were categorized into OAR, EVAR, and EE groups based on procedural codes. Statistical analyses, including t-tests, Fisher’s exact tests, Cox proportional hazard models, and multivariate Cox regression, assessed baseline characteristics, mortality risks, and factors within the EE group. Results The analysis encompassed 26,195 patients, with 66.19% in the EVAR group, 31.87% in the OAR group, and 1.94% in the EE group. EVAR cases steadily increased from 2002 to 2018. Survival rates favored EVAR, followed by OAR and EE. 30-day survival was lower in EE than EVAR. Multivariate analysis for EE revealed no risk factors for 30-days survival but identified age, chronic kidney disease, high Charlson Comorbidity Index scores, and less than 6 months since EVAR as risk factors for overall mortality. Conclusion Rising EE trends with increased EVAR adoption, particularly evident in the Korean dataset, underscore inferior outcomes. This highlights the critical need for strategic initial treatment decisions and timely interventions to enhance overall results and mitigate the unfavorable EE incidence.
Review on Lithium-ion Battery PHM from the Perspective of Key PHM Steps
Authors: Kong Jinzhen , Liu Jie , Zhu Jingzhe , Zhang Xi , Tsui Kwok-Leung , Peng Zhike , Wang Dong 
Published: July 2024

AbstractPrognostics and health management (PHM) has gotten considerable attention in the background of Industry 4.0. Battery PHM contributes to the reliable and safe operation of electric devices. Nevertheless, relevant reviews are still continuously updated over time. In this paper, we browsed extensive literature related to battery PHM from 2018 to 2023 and summarized advances in battery PHM field, including battery testing and public datasets, fault diagnosis and prediction methods, health status estimation and health management methods. The last topic includes state of health estimation methods, remaining useful life prediction methods and predictive maintenance methods. Each of these categories is introduced and discussed in details. Based on this survey, we accordingly discuss challenges left to battery PHM, and provide future research opportunities. This research systematically reviews recent research about battery PHM from the perspective of key PHM steps and provide some valuable prospects for researchers and practitioners.