bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of aliskiren in human serum quantities by HPLC–tandem mass spectrometry appropriate for pediatric trials
Authors: Burckhardt Bjoern B. , Ramusovic Sergej , Tins Jutta , Laeer Stephanie 
Published: October 2012

ABSTRACTThe orally active direct renin inhibitor aliskiren is approved for the treatment of essential hypertension in adults. Analytical methods utilized in clinical studies on efficacy and safety have not been fully described in the literature but need a large sample volume ranging from 200 to 700 μL, rendering them unsuitable particularly for pediatric applications. In the assay presented only 100 μL of serum is needed for mixed‐mode solid‐phase extraction. The chromatographic separation was performed on XselectTM C18 CSH columns with mobile phase consisting of methanol–water–formic acid (75:25:0.005, v/v/v) and a flow rate of 0.4 mL/min. Running in positive electrospray ionization and multiple reaction monitoring the mass spectrometer was set to analyze precursor ion 552.2 m/z [M + H]+ to product ion 436.2 m/z during a total run time of 5 min. The method covers a linear calibration range of 0.146–1200 ng/mL. Intra‐run and inter‐run precisions were 0.4–7.2 and 0.6–12.9%. Mean recovery was at least 89%. Selectivity, accuracy and stability results comply with current European Medicines Agency and Food and Drug Administration guidelines. This successfully validated LC‐MS/MS method with a wide linear calibration range requiring small serum amounts is suitable for pharmacokinetic investigations of aliskiren in pediatrics, adults and the elderly. Copyright © 2012 John Wiley & Sons, Ltd.
Anticipatory behavior in virtual universe, application to a virtual juggler
Authors: Buche C. , De Loor P. 
Published: October 2012

ABSTRACTTo be believable, virtual entities must be equipped with the ability to anticipate, that is, to predict the behavior of other entities and the subsequent consequences on the environment. For that purpose, we propose an original approach where the entity possesses an autonomous world of simulation within simulation, in which it can simulate itself (with its own model of behavior) and simulate the environment (with the representation of the behaviors of the other entities). This principle is illustrated by the development of an artificial juggler in 3D. In this application, the juggler predicts the motion of the balls in the air and uses its predictions to coordinate its own behavior to continue to juggle.Copyright © 2012 John Wiley & Sons, Ltd.
DNA‐Directed Growth of Pd Nanocrystals on Carbon Nanotubes towards Efficient Oxygen Reduction Reactions
Authors: Zhang Lian Ying , Guo Chun Xian , Cui Zhiming , Guo Jun , Dong Zhili , Li Chang Ming 
Published: October 2012

AbstractUnique DNA‐promoted Pd nanocrystals on carbon nanotubes (Pd/DNA–CNTs) are synthesized for the first time, in which through its regularly arranged PO43− groups on the sugar–phosphate backbone, DNA directs the growth of ultrasmall Pd nanocrytals with an average size of 3.4 nm uniformly distributed on CNTs. The Pd/DNA–CNT catalyst shows much more efficient electrocatalytic activity towards oxygen reduction reaction (ORR) with a much more positive onset potential, higher catalytic current density and better stability than other Pd‐based catalysts including Pd nanocrystals on carbon nanotubes (Pd/CNTs) without the use of DNA and commercial Pd/C catalyst. In addition, the Pd/DNA–CNTs catalyst provides high methanol tolerance. The high electrocatalytic performance is mainly contributed by the ultrasmall Pd nanocrystal particles grown directed by DNA to enhance the mass transport rate and to improve the utilization of the Pd catalyst. This work may demonstrate a universal approach to fabricate other superior metal nanocrystal catalysts with DNA promotion for broad applications in energy systems and sensing devices.
Study on 1,3,5‐Triazine Chemistry in Dehydrocondensation: Gauche Effect on the Generation of Active Triazinylammonium Species
Authors: Kunishima Munetaka , Ujigawa Takae , Nagaoka Yoshie , Kawachi Chiho , Hioki Kazuhito , Shiro Motoo 
Published: October 2012

AbstractThe reaction of 2‐chloro‐4,6‐dimethoxy‐1,3,5‐triazine (CDMT) with various nitrogen‐containing compounds, particularly tertiary amines (tert‐amines), has been studied for the preparation of 2‐(4,6‐dimethoxy‐1,3,5‐triazinyl)trialkylammonium salts [DMT‐Am(s)]. DMT‐Ams derived from aliphatic tert‐amines exhibited activity for the dehydrocondensation between a carboxylic acid and an amine to form an amide in a model reaction. Based on a conformational analysis of DMT‐Ams and tert‐amines by NMR and X‐ray diffraction methods, we concluded that a β‐alkyl group maintained in a gauche relationship with the nitrogen lone pair of tert‐amines significantly hinders the approach of CDMT to the nitrogen. Thus, trimethylamine and quinuclidine without such alkyl groups readily react with CDMT whereas triethylamine, possessing two or three such gauche β‐alkyl groups in the stable conformations, does not react at all. The theory of “gauche β‐alkyl group effect” proposed here provides useful guidelines for the preparation of DMT‐Ams possessing various tertiary amine moieties. An investigation of the dehydrocondensation activity of tert‐amines in a CDMT/tert‐amine system that involves in situ generation of DMT‐Am, showed that the gauche effect of the β‐alkyl group becomes quite pronounced; the yield of the amide decreases significantly with tert‐amines possessing an unavoidable gauche β‐alkyl group. Thus, the tert‐amine/CDMT systems are useful for judging whether tert‐amines can readily react with CDMT without isolation of DMT‐Ams.
ChemInform Abstract: Phase Transition and Conduction Mechanism of Rare Earth Based Tungsten‐Bronze Compounds.
Authors: Parida B. N. , Das Piyush R. , Padhee R. , Choudhary R. N. P. 
Published: October 2012

AbstractPolycrystalline materials Li2Pb2Ln2W2Ti4 Nb4O30 (Ln: Y, Eu) are synthesized by solid state reaction of Li2CO3, TiO2, Nb2O5, WO3, PbO, and Ln2O3 (alumina crucible, 1100 °C, 4 h).
ChemInform Abstract: A Cationic Antimonite Chain Templated by Sulfate: [Sb6O74+] [(SO42‐)2].
Authors: Fei Honghan , Han Cari S. , Oliver Scott R. J. 
Published: October 2012

AbstractColorless needlelike single crystals of the title compound are hydrothermally synthesized from aqueous solutions of Sb(OAc)3 and H2SO4 (autoclave, 150 °C, 72 h, 87% yield).
ChemInform Abstract: Nanoscale Hemispheres in Novel Mixed‐Valent Uranyl Chromate(V,VI), (C3NH10)10 [(UO2)13(Cr125+O42) (Cr6+O4)6(H2O)6] (H2O)6.
Authors: Siidra Oleg I. , Nazarchuk Evgeny V. , Petrunin Anatoly A. , Kayukov Roman A. , Krivovichev Sergey V. 
Published: October 2012

AbstractSingle crystals of the new title compound are hydrothermally obtained from aqueous solutions containing UO2(NO3)2, CrO3, and isopropylamine (autoclave, 100 °C, 8 d) followed by slow evaporation in air (21 d, 21% yield).
ChemInform Abstract: Highly Enantioselective Chlorination of β‐Keto Esters and Subsequent SN2 Displacement of Tertiary Chlorides: A Flexible Method for the Construction of Quaternary Stereogenic Centers.
Authors: Shibatomi Kazutaka , Soga Yoshinori , Narayama Akira , Fujisawa Ikuhide , Iwasa Seiji 
Published: October 2012

AbstractThe reaction occurs in the presence of the new ligands (I) affording α‐chlorinated products with high enantioselectivity.
ChemInform Abstract: Tungsten‐Catalyzed Heterocycloisomerization Approach to 4,5‐Dihydro‐benzo[b]furans and ‐indoles.
Authors: Fisher Ethan L. , Wilkerson‐Hill Sidney M. , Sarpong Richmond 
Published: October 2012

AbstractResulting benzofurans and indoles are versatile intermediates which can be used for further functionalizations.
ChemInform Abstract: A Facile and Economical Procedure for the Synthesis of Maleimide Derivatives Using an Acidic Ionic Liquid as a Catalyst.
Authors: Li Kai , Yuan Chao , Zheng Shijun , Fang Qiang 
Published: October 2012

AbstractA room temperature ionic liquid is applied as recyclable catalyst for the dehydrative cyclization of maleamic acid amides to N‐substituted maleimides.
ChemInform Abstract: Minimisation of E‐Factor in the Synthesis of N‐Hydroxylamines: The Role of Silver(I)‐Based Coordination Polymers.
Authors: Sheykhan Mehdi , Ranjbar Zohreh Rashidi , Morsali Ali , Heydari Akbar 
Published: October 2012

AbstractNano‐rods of silver complexed N,N′‐bis(4‐pyridyl formamide)‐1,4‐benzene bearing different anions are synthesized and applied as highly efficient catalysts in the partial oxidation of primary amines (I) and (III) with urea hydrogen peroxide to afford the corresponding hydroxylamines (II) and (IV).
ChemInform Abstract: Asymmetric Hydrogenation of N‐Alkyl and N‐Aryl Ketimines Using Chiral Cationic Ru(diamine) Complexes as Catalysts: The Counteranion and Solvent Effects, and Substrate Scope.
Authors: Chen Fei , Ding Ziyuan , He Yanmei , Qin Jie , Wang Tianli , Fan Qing‐Hua 
Published: October 2012

AbstractVarious complexes bearing different counterions are investigated and (I) is demonstrated to be the most effective one.
ChemInform Abstract: SBA‐15‐Functionalized Palladium Complex Partially Confined with Ionic Liquid: An Efficient and Reusable Catalyst System for Aqueous‐Phase Suzuki Reaction.
Authors: Karimi Babak , Zamani Asghar 
Published: October 2012

AbstractA very efficient and reusable (four times) catalyst is successfully applied to the Suzuki—Miyaura coupling reaction of the compounds (I) including aryl chlorides and heteroaryl halides.
ChemInform Abstract: Palladium‐Catalyzed Suzuki Cross‐Coupling Reaction Using a Fluorous NHC Ligand.
Authors: Wan Li , Yu Hong , Cai Chun 
Published: October 2012

AbstractThe utilization of N‐heterocyclic carbene palladium complex immobilized on fluorous silica gel through fluorous‐fluorous interactions in the Suzuki cross‐coupling reaction is described.
ChemInform Abstract: Highly Diastereo‐ and Enantioselective Cu‐Catalyzed [3 + 3] Cycloaddition of Propargyl Esters with Cyclic Enamines Toward Chiral Bicyclo[n.3.1] Frameworks.
Authors: Zhang Cheng , Hu Xin‐Hu , Wang Ya‐Hui , Zheng Zhuo , Xu Jie , Hu Xiang‐Ping 
Published: October 2012

AbstractFor the first time the mild, simple, and efficient title reaction, which can be used for a broad substrate scope, is presented.
ChemInform Abstract: Highly Selective Reactions of C60Cl6 with Thiols for the Synthesis of Functionalized [60]Fullerene Derivatives.
Authors: Troshin Pavel A. , et al. et al. 
Published: October 2012

AbstractThe potassium salts of compounds (IIIe) and (IIIf) show interesting activity against a broad panel of DNA and RNA viruses, like HIV‐1or influenza AH3N2 virus subtype.
ChemInform Abstract: Synthesis, Characterization and Bioactivity of Polysubstituted 1‐(4‐(1H‐Pyrrol‐1‐yl)phenyl)‐1H‐pyrrole Derivatives.
Authors: Elassar Abdel‐Zaher A. 
Published: October 2012

AbstractA variety of polysubstituted bispyrroles are synthesized by reaction of 1,4‐bis[(2‐oxopropyl)amino]benzene (III) with dimethylformamide dimethylacetal or active methylene compounds.
ChemInform Abstract: Diastereodivergent Synthesis of 3‐Spirocyclopropyl‐2‐oxindoles Through Direct Enantioselective Cyclopropanation of Oxindoles.
Authors: Dou Xiaowei , Lu Yixin 
Published: October 2012

AbstractThe direct organocatalytic asymmetric cyclopropanation reaction of oxindoles by employing oxindoles as C1 synthon and bromonitroolefins as a convenient C2 synthon is described.
ChemInform Abstract: New Approach to the Synthesis of 1,3‐Dioxolanes
Authors: Vol'eva V. B. , Belostotskaya I. S. , Malkova A. V. , Komissarova N. L. , Kurkovskaya L. N. , Usachev S. V. , Makarov G. G. 
Published: October 2012

Abstractusing transketalization reactions of ketal (III)
ChemInform Abstract: One‐Pot Synthesis of 1,2,3‐Triazoles from Boronic Acids in Water Using Cu(II)—β‐Cyclodextrin Complex as a Nanocatalyst.
Authors: Kaboudin Babak , Abedi Yaghoub , Yokomatsu Tsutomu 
Published: October 2012

AbstractThe efficient, simple, and rapid method, which uses a readily available and simple nanocatalyst in air without any additives, for the synthesis of the title compounds is reported and follows a click cyclization reaction.
ChemInform Abstract: C3‐Symmetric Trisimidazoline‐Catalyzed Enantioselective Bromolactonization of Internal Alkenoic Acids.
Authors: Murai Kenichi , Nakamura Akira , Matsushita Tomoyo , Shimura Masato , Fujioka Hiromichi 
Published: October 2012

AbstractThe catalytic, enantioselective bromolactonization of internal alkenoic acids is developed by using trisimidazoline as chiral catalyst.
ChemInform Abstract: Double Intramolecular 1,3‐Dipolar Cycloaddition of Diazido‐Terminal Dialkyne: Synthesis of a New Bis(1,2,3‐triazolo‐1,4‐oxazine) (IV).
Authors: Mekni Nejib Husein , Baklouti Ahmed 
Published: October 2012

AbstractThe title compound (IV) shows moderate antibacterial activity against Enterococcus feacium, however, it is inactive against E.
ChemInform Abstract: New Farnesyltransferase Inhibitors in the Phenothiazine Series.
Authors: Belei Dalila , Dumea Carmen , Samson Alexandrina , Farce Amaury , Dubois Joelle , Bicu Elena , Ghinet Alina 
Published: October 2012

AbstractPhenothiazine derivatives of type (III) and (IV) are prepared using click chemistry approach.
ChemInform Abstract: A Novel Franchetine Type Norditerpenoid Isolated from the Roots of Aconitum carmichaeli Debx. with Potential Analgesic Activity and Less Toxicity
Authors: Wang Dao‐Ping , Lou Hua‐Yong , Huang Lan , Hao Xiao‐Jiang , Liang Guang‐Yi , Yang Zai‐Chang , Pan Wei‐Dong 
Published: October 2012

Abstractisolation and structure of the new diterpenoid alkaloid, guiwuline (I), which exhibits potential analgesic activity
ChemInform Abstract: Approaches to Iodinated Derivatives of Vanillin and Isovanillin.
Authors: Nammalwar Baskar , Bunce Richard A. , Berlin K. Darrell , Bourne Christina R. , Bourne Philip C. , Barrow Esther W. , Barrow William W. 
Published: October 2012

AbstractPreviously unknown 5‐iodovanillin ethers like (VI) and (VIII) are prepared by a three‐step strategy consisting of ether cleavage, regioselective methylation and subsequent O‐alkylation.
A study of foam granulation and wet granulation in a twin screw extruder
Authors: Weatherley S. , Thompson M.R. , Sheskey P.J. 
Published: October 2012

AbstractThis research investigated a new technique known as foam granulation for the continuous manufacturing of pharmaceuticals by a twin screw extruder. Six grades of hypromellose were compared as binders in the trials, using two addition methods: foam injection by auxiliary side stuffer feeder and liquid injection directly into the extruder. The produced granules were tested for particle size, Carr compressibility index and characteristic fracture strength. It was found that granulation using foam injection improved powder lubrication inside the extruder and wetting uniformity of the lactose, as well as produced granules having lower Carr indices. © 2012 Canadian Society for Chemical Engineering
Structural Exploration of (3S,6S)‐6‐Benzhydryl‐N‐benzyltetrahydro‐2H‐pyran‐3‐amine Analogues: Identification of Potent Triple Monoamine Reuptake Inhibitors as Potential Antidepressants
Authors: Santra Soumava , Gogoi Sanjib , Gopishetty Bhaskar , Antonio Tamara , Zhen Juan , Reith Maarten E. A. , Dutta Aloke K. 
Published: October 2012

AbstractTo further explore the basic structural motifs (3S,6S)‐6‐benzhydryl‐N‐benzyltetrahydro‐2H‐pyran‐3‐amine and (2S,4R,5R)‐2‐benzhydryl‐5‐(benzylamino)tetrahydro‐2H‐pyran‐4‐ol, developed by our research group, for monoamine transport inhibition, we designed and synthesized various structurally altered analogues. The new compounds were tested for their affinities for the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET) in rat brain by measuring their capacity to inhibit the uptake of [3H]DA, [3H]5‐HT, and [3H]NE, respectively. Our results point to novel compounds with a TUI, DNRI, SNRI, or SSRI profile. Among the TUIs, compound 2 g exhibited a balanced potency for all three monoamine transporters (Ki: 60, 79, and 70.3 nM for DAT, SERT, and NET, respectively). In the rat forced swim test, compound 2 g produced a significant decrease in immobility in drug‐treated rats relative to vehicle, indicating a potential antidepressant property.
Conductive Photoswitchable Vanadium Oxide Nanopaper based on Bacterial Cellulose
Authors: Gutierrez Junkal , Fernandes Susana C. M. , Mondragon Iñaki , Tercjak Agnieszka 
Published: October 2012

AbstractA bacterial cellulose mat was used as a template for the fabrication of conductive photoswitchable hybrid nanopaper by the incorporation of sol‐gel synthesized vanadium nanoparticles. The resulting nanopaper, prepared through a green pathway, was able to photoinduce a reversible color change. Conductive properties at the nano‐ and macroscales were confirmed by electrostatic force microscopy and semiconductor analysis measurements, respectively.
A gain/efficiency‐enhanced bidirectional switched‐capacitor DC‐DC converter
Authors: Chang Yuen‐Haw , Wu Kun‐Wei 
Published: October 2012

SUMMARYA closed‐loop gain/efficiency‐enhanced bidirectional switched‐capacitor converter (BSCC) is proposed by combining an adaptive‐conversion‐ratio (ACR) phase generator and pulse‐width‐modulation (PWM) controller for bidirectional step‐up/down DC‐DC conversion and regulation. For realizing gain‐enhanced, the power part consists of onemc‐stage cell and onenc‐stage cell in cascade between low‐voltage (LV) and high‐voltage (HV) sides to boost HV voltage intomc × nctimes voltage of LV source at most, or convert LV voltage into 1/(mc × nc) times voltage of HV source at most. For realizing efficiency‐enhanced, the ACR idea with adapting stage numberm, nis built in the phase generator to obtain a suitable step‐up/down gain:m × nor 1/(m × n) (m = 1, 2, …, mc,n = 1, 2, …, nc). Further, the output regulation and robustness to source/loading variation can be enhanced by PWM on the LV/HV sides. Some theoretical analysis and control design are included as: modeling, steady‐state analysis, conversion ratio, efficiency, capacitance selection, and control design. Finally, the performance of this scheme is verified experimentally on a BSCC prototype, and all results are illustrated to show the efficacy of this scheme. Copyright © 2012 John Wiley & Sons, Ltd.
Extension of the variational equation to analog/digital circuits: numerical and experimental validation
Authors: Bizzarri Federico , Brambilla Angelo , Storti Gajani Giancarlo 
Published: October 2012

ABSTRACTConventional shooting methods cannot be used to determine the steady‐state solution of circuits whose model is characterised by a vector field exhibiting zero order discontinuities. In the analysis of circuits working on a stable limit cycle, this limitation prevents the use of methods that exploit Floquet theory to compute the variational model and thus the properties of the fundamental matrix and, for example, phase noise in oscillators. In this paper, we use an improved shooting method that solves this drawback by resorting to saltation matrices and show how this method makes possible the correct computation of the first left eigenfunction (known as ppv) of the fundamental matrix. ppvs are a key aspect in determining phase noise. The results obtained through numerical simulations are compared with measurements on a relaxation oscillator serving as a simple but significant comparison vehicle. Copyright © 2012 John Wiley & Sons, Ltd.
Magnetic Structures of HoCoO3 and TbCoO3
Authors: Muñoz Angel , Martínez‐Lope María J. , Alonso Jose A. , Fernández‐Díaz María T. 
Published: October 2012

AbstractThe magnetic behavior of HoCoO3 and TbCoO3 has been studied from magnetic measurements and neutron diffraction experiments performed on polycrystalline samples. The magnetic measurements indicate that the Co3+ ions exhibit a low‐spin electronic configuration t2g6eg0 with S = 0 below room temperature. The neutron diffraction data show that HoCoO3 and TbCoO3 order with an antiferromagnetic structure below TN = 3 and 3.6 K, respectively. The magnetic structure for HoCoO3 and TbCoO3 are given by the basis vectors (Ax,0,Cz) and (Cx,0,Az), respectively. Therefore, the magnetic moments are in the (010) plane. At T = 1.5 K, the ordered magnetic moments of Ho3+ and Tb3+ ions are 6.48(4) and 7.86(4) μB, respectively.
Essential role of β‐human 8‐oxoguanine DNA glycosylase 1 in mitochondrial oxidative DNA repair
Authors: Su Yu‐Hung , Lee Yen‐Ling , Chen Sung‐Fang , Lee Yun‐Ping , Hsieh Yi‐Hsuan , Tsai Jui‐He , Hsu Jye‐Lin , Tian Wei‐Ting , Huang Wenya 
Published: October 2012

Abstract8‐Oxoguanine (8‐OG) is the major mutagenic base lesion in DNA caused by reactive oxygen species (ROS) and accumulates in both nuclear and mitochondrial DNA (mtDNA). In humans, 8‐OG is primarily removed by human 8‐OG DNA glycosylase 1 (hOGG1) through the base excision repair (BER) pathway. There are two major hOGG1 isoforms, designated α‐ and β‐hOGG1, generated by alternative splicing, and they have distinct subcellular localization: cell nuclei and mitochondria, respectively. Using yeast two‐hybrid screening assays, we found that β‐ but not α‐hOGG1 directly interacts with the mitochondrial protein NADH:ubiquinone oxidoreductase 1 beta subcomplex 10 (NDUFB10), an integral factor in Complex 1 on the mitochondrial inner membrane. Using coimmunoprecipitation and immunofluorescence studies, we found that this interaction was greatly increased by hydrogen peroxide‐induced oxidative stress, suggesting that β‐ but not α‐hOGG1 is localized in the mitochondrial inner membrane. Analyses of nuclear and mtDNA damage showed that the β‐ but not α‐ hogg1 knockdown (KD) cells were severely defective in mitochondrial BER, indicating an essential requirement of β‐hOGG1 for mtDNA repair. β‐hogg1 KD cells were also found to be mildly deficient in Complex I activity, suggesting that β‐hOGG1 is an accessory factor for the mitochondrial integral function for ATP synthesis. In summary, our findings define β‐hOGG1 as an important factor for mitochondrial BER and as an accessory factor in the mitochondrial Complex I function. Mol. Mutagen. 2013. © 2012 Wiley Periodicals, Inc.