bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of efficacy and safety of sarpogrelate-based anti-platelet therapy with non-sarpogrelate-based anti-platelet therapy following arterial endovascular therapy: a systematic review
Authors: Jhajj Loveleen , Razick Shakira , Batea Khaleefah Balsam , Razick Abdulla , Moutasim Suliman Mohammed , Thapar Nandita , Thakali Hira 
Published: August 2024

Objective:
Sarpogrelate is a selective serotonin/5-hydroxytryptamine 2A receptor antagonist used in the management of peripheral artery disease (PAD). The drug has emerged as a promising choice for medical management post-endovascular therapy (EVT) due to its anti-platelet aggregation, vasoconstriction, and anti-vascular smooth muscle proliferation properties. The aim of the meta-analysis is to evaluate the efficacy and safety of sarpogrelate-based APT following arterial EVTs in PAD.

Material and methods:
PubMed, Google Scholar, Scopus, and the Cochrane were systematically searched from inception to December 2023. Any randomized controlled trial studies in English that evaluated the efficacy and safety of sarpogrelate-based APT after EVT in patients with PAD was included. Data on the restenosis rate, target lesion revascularization (TLR), and safety parameters were extracted and studied. The pooled differences in efficacy and safety parameters between sarpogrelate-based APT and non-sarpogrelate-based APT was calculated using the relative risk (RR) with a 95% CI.

Results:
A total of three randomized controlled trials were included out of 354 articles obtained through a literature search. No significant differences were observed in the risk of restenosis (RR=0.74, 95% CI= 0.55–1.00, P=0.954) and TLR (RR=0.76, 95% CI= 0.47–1.23, P=0.476) among patients being treated with sarpogrelate and non-sarpogrelate-based APT. Likewise, sarpogrelate-based APT had a similar safety profile as non-sarpogrelate-based APT.

Conclusion:
Sarpogrelate-based APT can be considered an effective alternative to clopidogrel-based conventional APT after EVTs. However, there is a huge need for a larger multicenter, multinational, and multiethnic global trial with sufficient participants in order to produce generalizable findings.
Drug-resistant schizophrenia-like psychosis associated with temporal non-anaplastic pleomorphic xanthoastrocytoma: unusual revealing symptom of a rare pathology
Authors: Borni Mehdi , Kammoun Brahim , Masmoudi Rim , Abdelkefi Mariam , Gouiaa Naourez , Ayedi Amal , Boudawara Mohamed Zaher 
Published: August 2024

Introduction and importance:
Pleomorphic xanthoastrocytoma (PXA) was first described by Kepes et al. in 1979. Fewer than 200 cases have been reported in the literature. It generally involves the temporoparietal lobe. PXA has a favorable prognosis. The most reported clinical manifestation is epileptic seizures. Revealing psychiatric symptoms have an incidence varying from 50 to 78%. The most common symptoms encountered are anxiety disorders, depression, schizophrenia-like psychosis, cognitive dysfunction or even anorexia nervosa.

Case presentation:
Here, the authors report a new case of non-anaplastic pleomorphic xanthoastrocytoma revealed by a drug-resistant schizophrenia-like psychosis in a 26-year-old male patient known with epileptic seizures in whom these two pathologies were intertwined and had been evolving for 5 years. The postoperative course was uneventful, and positive symptoms of schizophrenia were relatively stabilized at discharge.

Clinical discussion:
Given the superficial hemispheric location of PXA, the most common clinical presentation is seizures. Psychiatric symptoms revealing brain tumors have an incidence varying from 50 to 78%. Most of these symptoms concern frontal and limbal tumors. In their case, the tumor was located in the right temporal lobe. Surgery was performed and postoperative course was uneventful even though there are conflicting reports regarding the importance of the surgical excision quality.

Conclusion:
PXA remains a rare and benign primary CNS tumor. Psychiatric disorders represent a rare revealing mode of this pathology, which must lead to neuroimaging in any patient carrying this type of symptoms.
Ethical considerations in surgical research conducted in African LMICs: a comprehensive narrative review
Authors: Uwishema Olivier , El Fil Serene , Rupani Ameen , Rizwan Ahmed Aisha , Ratnani Tanya , MohanaSundaram ArunSundar , Mshaymesh Sarah , Nazir Abubakar 
Published: August 2024

Introduction:
Surgical research has revolutionized healthcare by improving the efficacy, safety, and efficiency of surgical interventions. This research has the potential to significantly impact healthcare delivery in Africa, where surgical diseases pose a major public health burden. Studies suggest surgery alone could reduce the global disease burden by 11%, with a substantial portion stemming from conditions prevalent in sub-Saharan Africa like traumatic injuries, childbirth complications, and surgical infections. However, conducting surgical research in Africa presents unique ethical challenges. The continent’s diverse socio-economic environments and rich cultural contexts necessitate careful consideration of ethical principles. Traditional research models often don’t translate well to African settings, raising concerns about informed consent, community engagement, and benefit-sharing.

Aim:
This review aims to shed light on various ethical dilemmas posed within surgical research, conducted in African countries. Further, standard practices and recommendations that involve a multi-pronged approach to mitigate said issues were explored.

Materials and methods:
A meticulous analysis of the existing literature pertaining to the ethical issues proffered in Africa was performed. Databases employed comprised PubMed/MEDLINE, Embase, Scopus, and EBSCOhost. Pertinent case studies were also reviewed to comprehend said issues, providing comprehensive recommendations.

Results:
In addressing the ethical challenges in the research, the importance of resource limitation, sociocultural factors, informed consent barriers, technological obsolescence, training deficits, power dynamics, vulnerable populations, regulatory oversight, and compliance was highlighted. The proposed approaches include conducting focused research lectures and practical workshops on surgery, organizing surgical boot camps for medical students, interns, and residents, promoting research in related fields such as anesthesia, radiology, and pathology, ensuring the presence of on-site surgeons as needed, and arranging outreach surgical and educational camps for patients.

Conclusion:
Promoting community engagement and training local researchers and surgeons are crucial for navigating the unique ethical landscape in Africa. By prioritizing ethical considerations, surgical research can contribute to improved healthcare outcomes and a more equitable healthcare system across the continent.
Vermian multinodular and vacuolating lesion of unknown significance discovered following syncope: a case report
Authors: Passanisi Maurizio , Marrone Salvatore , Scalia Gianluca , Cicero Salvatore , Chaurasia Bipin , Umana Giuseppe E. 
Published: August 2024

Introduction and importance:
Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance (MV PLUS) are benign cystic lesions that, though typically asymptomatic, can present with neurological symptoms such as seizures, headaches, and syncope. These lesions are predominantly found in sub-tentorial brain structures but can also appear in supratentorial areas. MRI is crucial in detecting these lesions, characterized by small nodules with high intensity on T2-FLAIR sequences. Despite increasing awareness, the pathophysiology and classification of MV PLUS lesions remain unclear, necessitating further research and careful monitoring.

Case presentation:
A 52-year-old female presented with subjective dizziness and a recent syncope episode. Neurological examination showed ataxia and a positive Romberg sign. MRI revealed a multicystic and nodular lesion in the vermian and paravermian regions, with altered signal intensity on T1-weighted and FLAIR sequences. The lesion showed no pathological enhancement post-gadolinium administration, and spectroscopy revealed no significant metabolite peaks. Clinical improvement was observed following corticosteroid and antivertiginous therapy, and the patient was discharged with a recommendation for neuroradiological follow-up.

Clinical discussion:
MV PLUS lesions are a subset of multinodular and vacuolating lesions that present significant diagnostic challenges due to their complex radiological features. First described in 2013, these lesions have distinct MRI characteristics, including a nodular appearance with high T2-FLAIR intensity and occasional cystic components. Despite being benign and typically stable, the differential diagnosis includes various other intracranial lesions, requiring careful evaluation. The pathogenesis and optimal management strategies for MV PLUS lesions are still under investigation, emphasizing the need for continued research.

Conclusion:
MV PLUS lesions, although rare and benign, present unique diagnostic challenges due to their varied radiological features and potential neurological symptoms. Regular MRI monitoring is essential to track their stability, given the current lack of understanding regarding their pathophysiology and long-term implications. Further research is needed to elucidate the etiology, natural history, and optimal management of these intriguing lesions.
A comorbidity of ulcerative colitis, ankylosing spondylitis, Takayasu’s arteritis and silent thyroiditis: an extensive case-based review
Authors: Ghabally Mike , Roumieh George , Qadabashi Khaled , Dayekh Jessica , Baydoun Esber , Jondiah Yusef , Shami Besher , jriekh Ziena 
Published: August 2024

Introduction and importance:
Ulcerative colitis is a chronic condition characterized by continuous inflammation of the rectum and colon. Its clinical complications extend beyond the gastrointestinal tract to involve multiple systems, including musculoskeletal, hepatobiliary, cardiovascular, and ocular manifestations. Takayasu arteritis and ankylosing spondylitis are two autoimmune inflammatory disorders that have previously been reported as coexisting conditions associated with ulcerative colitis. is an autoimmune-mediated inflammation of the thyroid gland causing the release of thyroid hormones and is considered a variant form of chronic autoimmune thyroiditis (Hashimoto’s thyroiditis).

Case presentation:
The authors report a case of a 32-year-old Caucasian man with a 3-year history of ulcerative colitis who presented to our clinic in 2015, complaining of chronic lower back pain that alleviates with exercise but does not relieve with rest. Based on our physical exam findings and lab results, ankylosing spondylitis was diagnosed using Assessment of Spondylarthritis International Society and New York criteria. Computerized tomography angiography was performed and demonstrated stenosis in multiple arteries. These findings satisfied the American College of Rheumatology criteria for Takayasu’s disease. After the Infliximab was started, the patient had significant symptomatic improvement.

Clinical discussion:
The use of biological therapy plays a key role in the treatment of many autoimmune illnesses. The patient was considered resistant and nonresponsive to treatment; thus, biological therapy was indicated, and infliximab was administered, resulting in a significant clinical improvement and remission of all illnesses.

Conclusion:
The authors aim to report a rare coexistence of ulcerative colitis, ankylosing spondylitis, Takayasu’s arteritis and silent thyroiditis. And the authors believe this can aid in diagnosing and management of rare diseases.
A Nurse-Driven Plan to Diminish First-Case Operating Room Delays
Authors: Blair Kathleen , Mijatovic Olivera , Thompson Melanie , Monroe Martha , Davies Claire C. 
Published: August 2024

OBJECTIVE
The purpose of this study was to examine the use of a nurse-driven plan to describe factors associated with delays in the 1st case on time start within the operating room.

METHODS
A posttest-only quasi-experiment was conducted to examine the effect of designating specific time periods for steps in the preoperative process on 1st case operating delays. Rationale for delays was also examined. Using an audit form, data on target time, time met, delay in minutes, and reasons for delay were collected by an observer.

RESULTS
Thirty-one percent (n = 31) of patient/participants (N = 99) were late to the operating room. Controllable factors, such as caregivers being late, and uncontrollable factors, such as patients' needing to use the restroom just prior to surgery, were identified.

CONCLUSIONS
Results of this study support the identification and examination of steps in the preoperative process to prevent delays by adjusting activities as needed. Identifying controllable and uncontrollable factors can help in preparing to prevent delays.
Green human resource management and sustainable performance in the wine industry: the mediating role of green innovation
Authors: Martínez-Falcó Javier , Sánchez-García Eduardo , Marco-Lajara Bartolomé , Georgantzis Nikolaos 
Published: August 2024

PurposeThe present study seeks to assess the effect of Green Human Resource Management (GHRM) on the Sustainable Performance (SP) of wineries as well as to explore the mediating role of Green Innovation (GI) in this respect. In addition, age, size and Protected Designation of Origin (PDO) membership are incorporated as control variables to increase the precision of the cause-effect relationships examined.Design/methodology/approachA conceptual model was created in order to fulfill the targeted research goals and then validated through PLS-SEM with primary data obtained from a survey administered to 196 Spanish wineries, taking place between September 2022 and January 2023.FindingsThe study findings indicate that GHRM has a positive and significant impact on the SP of wineries. In addition, GI appears to partially mediate this relationship.Originality/valueThis study is justified by various grounds for its originality. First, there is a lack of prior research examining the impact of GHRM practices in the wine industry, making this study a unique opportunity to explore and leverage existing knowledge in the fields of environmental management and human resources in order to generate new insights on the topic. Second, the academic literature analyzing this particular construct is scarce, underscoring the aim of this research to contribute to the accumulation of relevant knowledge in this area. Third, GHRM serves to elucidate the mechanisms through which valuable personnel can be attracted and retained in wineries within the post-COVID context.
Do energy performance certificates influence time on market? An exploratory research of the residential housing market in Flanders
Authors: Gerassimenko Alesia , De Moor Lieven , Defau Laurens 
Published: August 2024

Purpose
Literature has already analysed the relation between a property’s time on market (TOM) and other housing characteristics, but few to none include the property’s energy performance certificates (EPC) and none make a comparison between the selling and rental market. This paper aims to address these gaps by studying the relationship between TOM, price and EPC in both markets.

Design/methodology/approach
By introducing a combination of alternative tests, this study confirms a causal relation between TOM and price in the cross-sectional data. This allows this study to use a two-stage least square model and analyse 392,498 Flemish sale and rental properties transacted between 2019 and 2023.

Findings
The results indicate that both sale and rental properties with higher prices increase the TOM by 4–6 days, and this effect is even stronger in the selling market when the value-added tax is included. This study also finds that EPC labels have a complex relation with the time on market. A-labelled properties tend to increase the transaction time between 10 and 54 days, but B- and C-labelled properties decrease TOM between 20 and 30 days. In addition, the poorer performing labels (E and F) react differently across markets because of market-specific policies.

Originality/value
This paper provides novel insights by studying the relationship between TOM and EPC while also considering TOM’s endogenous relationship with the price. We control for these relationships in both the selling and rental market.
Fine‐scale alpine plant community assembly: Relative roles of environmental sorting, dispersal processes and species interactions
Authors: Helm Norbert , Chytrý Kryštof , Hülber Karl , Moser Dietmar , Wessely Johannes , Gattringer Andreas , Hausharter Johannes , Pauli Harald , Winkler Manuela , Saccone Patrick , Lamprecht Andrea , Rutzinger Martin , Mayr Andreas , Kollert Andreas , Dullinger Stefan 
Published: August 2024

Abstract

Besides environmental sorting, other processes like biotic interactions and dispersal limitation are vital for the assembly of plant communities in high mountains and their re‐assembly under changing climatic conditions. Nevertheless, studies that compare the impact of these factors on plant community assembly above the tree line are largely lacking so far.

We analysed occurrence changes in vascular plant communities of 492 permanent 1‐m2 plots in the alpine‐nival ecotone of Mt. Schrankogel, Austrian Alps by comparing resurvey data from 2014 with data from the initial survey in 1994. We combined these data with species inventories from 899 additional plots sampled in 2021 and 2022 across a larger landscape above the tree line covering an elevational range of 1700 m, which we used for fine‐scale habitat suitability modelling. We assessed the relative effects of projected habitat suitability, propagule pressure from surrounding populations and biomass density of neighbours on 1532 colonization and 372 extirpation events of 31 species observed on the permanent plots.

We found that all three factors are significantly related to both colonisations and extirpations, with habitat suitability having the strongest, propagule pressure a slightly weaker, and vegetation density the weakest effect. Colonisations can be better explained by the three process proxies than extirpations.

Our results indicate a crucial role of dispersal limitation besides the predominant effect of environmental filtering on the (re‐)assembly of the alpine‐nival plant community, while competitive/facilitative effects between plants tend to play a minor role. The strong imprint of nearby source plant populations on colonization/extirpation events suggests that recent plant migrations predominantly occur in small steps. This implies that while the topographically complex alpine terrain offers climatic microrefugia for plants, it may also pose potential barriers, hindering species from following their suitable climatic niches upwards.

Synthesis: Besides filtering by environmental conditions dispersal limitation had a strong effect on the observed changes in a local alpine plant community over two decades. Limited dispersal capacities of plant species may counteract the ability of isolated cold areas to effectively shelter high alpine plants from the effects of climate warming.
Application of the Agilent 2100 Bioanalyzer instrument as quality control for next‐generation sequencing
Authors: Senst Alina , Bonsiepe Hannah , Kron Sarah , Schulz Iris 
Published: August 2024

AbstractNext‐generation sequencing (NGS) technologies have expanded the spectrum of forensic DNA analysis by facilitating efficient and precise genotyping of a large number of genetic markers. Yet, challenges persist regarding complex sample processing and assurance of equal molar concentrations across pooled samples. Since optimal cluster density is crucial for sequencing performance, the determination of both quantity and quality is indispensable for library preparation. In this study, we investigated the application of the Agilent 2100 Bioanalyzer for library quality control, as studies for forensic approaches, particularly for highly degraded postmortem samples, are rare. Our analysis encompassed assessing total DNA concentrations, fluorescence unit (FU) values, and adapter dimer concentrations in purified DNA libraries derived from buccal swabs and tissue samples of decomposed corpses. The sensitivity study tested a serial dilution derived from buccal swabs and revealed a decrease in FU values and an increase in adapter dimers with declining DNA input concentrations. Deviations in total DNA concentrations and average peak heights between the Agilent 2100 Bioanalyzer runs indicated a lack of repeatability in data and presented challenges in accurate quantification, which was also observed in previous studies. Yet, the analysis of degraded samples from decomposed human remains has shown the ability to detect adapter dimer concentrations, which can be crucial for the quality of subsequent NGS library preparation and sequencing success. Therefore, the Agilent 2100 Bioanalyzer proves to be a valuable tool for NGS quality control.
Surveillance of influenza A and B viruses from community and hospital wastewater treatment plants
Authors: Panneerselvam Sneka , Manayan Parambil Athira , Jayaram Anup , Varamballi Prasad , Mukhopadhyay Chiranjay , Jagadesh Anitha 
Published: August 2024

AbstractInfluenza virus is a well‐known pathogen that can cause epidemics and pandemics. Several surveillance methods are being followed to monitor the transmission patterns and spread of influenza in the community. Wastewater‐based Epidemiology (WBE) can serve as an additional tool to detect the presence of influenza viruses. The current study primarily focuses on surveillance of Influenza A and Influenza B in wastewater treatment plant (WWTP) samples. A total of 100 wastewater samples were collected in July (n = 50) and August (n = 50) 2023 from four different WWTPs in Manipal and Udupi, district of Karnataka, India. The WWTP samples were processed and tested by Real‐Time reverse transcriptase PCR (RT‐PCR). The data generated was analysed in comparison with the clinical Influenza cases. Of the 100 samples, 18 (18%) tested positive for Influenza A virus and 2 (2%) tested positive for Influenza B virus, with a viral load ranging 1.4 x 102–2.2 x 103 gc/L for influenza A virus and 5.2 x 103–7.7 x 103gc/L for influenza B virus. On correlating the WWTP positivity with clinical case, it was found that influenza clinical cases and virus positivity in wastewater increased simultaneously, emphasizing WBE as a concurrent method for monitoring influenza virus activity.