bluuebunny/crossref_metadata_2025_split huggingface dataset:
A highly diverse, desert-like microbial biocenosis on solar panels in a Mediterranean city
Authors: Dorado-Morales Pedro , Vilanova Cristina , Peretó Juli , Codoñer Franscisco M. , Ramón Daniel , Porcar Manuel 
Published: October 2015

AbstractMicroorganisms colonize a wide range of natural and artificial environments although there are hardly any data on the microbial ecology of one the most widespread man-made extreme structures: solar panels. Here we show that solar panels in a Mediterranean city (Valencia, Spain) harbor a highly diverse microbial community with more than 500 different species per panel, most of which belong to drought-, heat- and radiation-adapted bacterial genera, and sun-irradiation adapted epiphytic fungi. The taxonomic and functional profiles of this microbial community and the characterization of selected culturable bacteria reveal the existence of a diverse mesophilic microbial community on the panels surface. This biocenosis proved to be more similar to the ones inhabiting deserts than to any human or urban microbial ecosystem. This unique microbial community shows different day/night proteomic profiles; it is dominated by reddish pigment- and sphingolipid-producers, and is adapted to withstand circadian cycles of high temperatures, desiccation and solar radiation.
Cloning, expression, crystallization and crystallographic analysis of CouR fromRhodopseudomonas palustris
Authors: Pan Chen , Hu Yong-lin , Jiang Xiang-ning , Gai Ying 
Published: October 2015

CouR fromRhodopseudomonas palustrisis a member of the MarR transcriptional regulator family. It regulates the expression of CouA and CouB, enzymes that are involved in the degradation ofp-coumarate.In vivo, CouR binds to a DNA fragment containing thecouABpromoter and suppresses the expression of CouA and CouB, while binding ofp-coumaroyl-CoA attenuates its affinity towards DNA and activates the expression of CouA and CouB. Here, the crystallization and X-ray diffraction analyses of CouR alone and in complex withp-coumaroyl-CoA are reported. Apo and ligand-complexed CouR crystals diffracted to 2.5 and 3.3 Å resolution, respectively. The crystals of apo CouR belonged to space groupP22121, with unit-cell parametersa= 62.78,b = 76.15,c = 87.38 Å, whereas the crystals of the CouR–ligand complex belonged to space groupP212121, with unit-cell parametersa= 61.37,b= 69.82,c = 70.32 Å. The crystals were predicted to contain two CouR molecules or CouR–ligand complexes per asymmetric unit.
Sourcing portfolio analysis and power positioning: towards a “paradigm shift” in category management and strategic sourcing
Authors: Cox Andrew 
Published: October 2015

Purpose– The paper aims to present the case for a “paradigm shift” in current thinking about how to undertake category management and develop sourcing strategies using power positioning techniques. The case is made based on the growing evidence of a mismatch between currently dominant academic and consulting methodologies and the reality of professional managerial practice.Design/methodology/approach– The paper provides a critique of the currently dominant thinking about how to conduct category management and strategic sourcing using the Kraljic Purchasing Portfolio Analysis methodology and the more recent Purchasing Chessboard approach. The critique focuses on their lack of analytical rigour when segmenting categories of supply, and their lack of robustness when making practical recommendations for managers when developing sourcing strategies.Findings– The paper demonstrates how (building on the initial power positioning approach outlined, but not fully developed, by Kraljic) a new approach to portfolio analysis can be developed. Sourcing Portfolio Analysis identifies over 30 strategic sourcing strategies for managers to utilise. Using a simple case study, the power of this new methodology to provide managers with more comprehensive and effective sourcing strategies is demonstrated.Research limitations/implications– Because of the power of this new approach, and the need to challenge existing methodologies, researchers are encouraged to utilise it and try help to generate a “paradigm shift” in current thinking within the profession.Practical implications– The paper provides the basis for a future more strategic supply management, rather than the currently tactical spend management, approach to sourcing.Originality/value– This paper provides a new approach to portfolio analysis.
Complementary theories to supply chain management revisited – from borrowing theories to theorizing
Authors: Halldórsson Árni , Hsuan Juliana , Kotzab Herbert 
Published: October 2015

Purpose– The aim of this paper is to identify ways by which the theorizing of supply chain management (SCM) takes place, with particular attention to complementary theories. SCM suffers as well as benefits from a “conceptual slack”.Design/methodology/approach– The nature of SCM is discussed, and the role and relevance of theorizing is addressed by using key characteristics of “academic scholarship” based on a literature review of SCM and evaluation of application of theory and theory development.Findings– The integrative and multi-layered nature of SCM sets the conditions for “theorizing SCM” that can take place through various forms: theory application, new theoretical combinations and sensitivity to managerial practice. It is pivotal that future research explore further the performative potential of SCM.Research limitations/implications– Research with focus on theory development or using complementary theories to advancing understanding of SCM can benefit from the five building blocks of theorizing SCM proposed in the paper.Practical implications– Theoretical principles in SCM are not only used to describe practical problems but also to “produce the world”; supply chains can be seen as organizational units that act or consummate an action that delivers a particular performance.Originality/value– This paper portrays SCM sensitivity to managerial challenges by moving from borrowing to a more bilateral view on theorizing of SCM, reflecting the nature of SCM.
Evolution of the migratory supply chain model
Authors: Potter Andrew , Towill Denis R , Christopher Martin 
Published: October 2015

Purpose– The purpose of this paper is to reflect upon the impact of the original work and provide an updated model to reflect the changing environment for supply chains. In 2000, a migratory model for supply chain evolution was proposed.Design/methodology/approach– The authors start by analysing the content of the papers that have cited the original Christopher and Towill (2000) paper. The development of an updated migratory model is informed by the findings from this, and then demonstrated through a case study of the book supply chain.Findings– Despite being the major contribution, the majority of citing papers actually use other parts of the original work, and some potential reasons for this are proposed. An extra stage is added to the migratory model, reflecting a customer centric strategy.Research limitations/implications– Given that the migratory model appears under-researched, the authors identify this as an opportunity for future research and suggest that methods less common in supply chain management are used.Practical implications– The updated migratory model can be used by supply chain managers to develop appropriate supply chain strategies for their organisations, while emphasising that many of the underlying tools to enable this reflect traditional industrial engineering approaches.Originality/value– The updated migratory model represents a new contribution to understanding the evolution of supply chains.
Why supply chain collaboration fails: the socio-structural view of resistance to relational strategies
Authors: Fawcett Stanley E. , McCarter Matthew W. , Fawcett Amydee M , Webb G Scott , Magnan Gregory M 
Published: October 2015

Purpose– The purpose of this study is to elaborate theory regarding the reasons why collaboration strategies fail. The relational view posits that supply chain integration can be a source of competitive advantage. Few firms, however, successfully co-create value to attain supernormal relational rents.Design/methodology/approach– This study uses a quasi-longitudinal, multi-case interview methodology to explore the reasons why collaboration strategies fail to deliver intended results. The authors interviewed managers at 49 companies in Period 1 and managers at 57 companies in Period 2. In all, 15 companies participated in both rounds of interviews.Findings– This study builds and describes a taxonomy of relational resistors. The authors then explore how sociological and structural resistors reinforce each other to undermine collaborative behavior. Specifically, the interplay among resistors: obscures the true sources of resistance; exacerbates a sense of vulnerability to non-collaborative behavior that reduces the willingness to invest in relational architecture; and inhibits the development of essential relational skills and organizational routines.Originality/value– This research identifies and describes the behaviors and processes that impede successful supply chain alliances. By delving into the interplay among relational resistors, the research explains the detail and nuance of inter-firm rivalry and supply chain complexity. Ultimately, it is the re-enforcing nature of various resistors that make it so difficult for firms to realize relational rents.
Variation and macroevolution in leaf functional traits in the Hawaiian silversword alliance (Asteraceae)
Authors: Blonder Benjamin , Baldwin Bruce G. , Enquist Brian J. , Robichaux Robert H. 
Published: October 2015

Summary

The Hawaiian silversword alliance is a spectacular example of plant adaptive radiation. The lineage includes 33 species in three endemic genera (Argyroxiphium, Dubautia and Wilkesia) that occupy almost all major habitats of the Hawaiian archipelago.

Here, we quantitatively explore functional diversification in the lineage by linking measurements of multiple leaf functional traits with climate niche and phylogenetic data.

We show that leaf functional trait variation (i) spans much of the global angiosperm range, (ii) is best explained by a white‐noise evolutionary model and (iii) is integrated in ways consistent with both the global leaf economics spectrum and the predictions of leaf venation network theory.

Our results highlight the importance of functional diversification and integration in rapidly evolving plant lineages. They also provide compelling additional support for the view that the Hawaiian silversword alliance is one of the world's premier examples of adaptive radiation in plants.
Industrial Agglomeration and Environmental Degradation: Empirical Evidence in Chinese Cities
Authors: Sun Puyang , Yuan Yan 
Published: October 2015

AbstractAn array of cross‐country studies have investigated both theoretically and empirically the relationship between industrial agglomeration and environmental quality. However, the literature lacks evidence from within one particular country. This paper examines the impacts of industrial agglomeration on the shape of the standard environmental Kuznets curve using 287 prefecture‐level cities in China over the period 2003–2008. Our results confirm its significant impacts on both the slope and the height of the environmental Kuznets curve. Furthermore, we find that cities with higher levels of manufacturing agglomeration are associated with more serious environmental degradation while cities with higher levels of service agglomeration show a tendency of higher environmental quality.
Monitoring to Learn, Learning to Monitor: A Critical Analysis of Opportunities for Indigenous Community‐Based Monitoring of Environmental Change in Australian Rangelands
Authors: Wiseman Nathanael D. , Bardsley Douglas K. 
Published: October 2015

AbstractIndigenous community‐based monitoring has been a central feature in many international attempts to improve monitoring of and local adaptation to environmental change. Despite offering much promise, Indigenous community‐based monitoring has been underutilised in natural resource management in Australia, particularly within the remote, semi‐arid rangelands. This paper discusses contextual social and environmental factors that may help to explain this apparent deficiency, before critically analysing key stakeholder perceptions of the roles for, and challenges of monitoring in the Alinytjara Wilurara Natural Resources Management region in the north‐west of South Australia. The analysis guides a discussion of responses to better integrate monitoring in general, and Indigenous community‐based monitoring in particular, into regional environmental management approaches. We argue that community‐based monitoring offers a range of benefits, including: better coordination between stakeholders; a heightened ability to detect and respond to climatic trends and impacts; the effective utilisation of Indigenous knowledge; employment opportunities for managing and monitoring natural resources; and improved learning and understanding of rangeland socio‐ecological systems. Identified opportunities for spatial and temporal community monitoring designed for the Alinytjara Wilurara region could be of value to other remote rangeland and Indigenous institutions charged with the difficult task of monitoring, learning from, and responding to environmental change.
Accuracy of genomic selection for age at puberty in a multi‐breed population of tropically adapted beef cattle
Authors: Farah M. M. , Swan A. A. , Fortes M. R. S. , Fonseca R. , Moore S. S. , Kelly M. J. 
Published: October 2015

SummaryGenomic selection is becoming a standard tool in livestock breeding programs, particularly for traits that are hard to measure. Accuracy of genomic selection can be improved by increasing the quantity and quality of data and potentially by improving analytical methods. Adding genotypes and phenotypes from additional breeds or crosses often improves the accuracy of genomic predictions but requires specific methodology. A model was developed to incorporate breed composition estimated from genotypes into genomic selection models. This method was applied to age at puberty data in female beef cattle (as estimated from age at first observation of a corpus luteum) from a mix of Brahman and Tropical Composite beef cattle. In this dataset, the new model incorporating breed composition did not increase the accuracy of genomic selection. However, the breeding values exhibited slightly less bias (as assessed by deviation of regression of phenotype on genomic breeding values from the expected value of 1). Adding additional Brahman animals to the Tropical Composite analysis increased the accuracy of genomic predictions and did not affect the accuracy of the Brahman predictions.
A population database study of outcomes associated with vitamin K antagonists in atrial fibrillation before DOAC
Authors: Blin Patrick , Dureau‐Pournin Caroline , Lassalle Regis , Abouelfath Abdelilah , Droz‐Perroteau Cécile , Moore Nicholas 
Published: October 2015

AimsThis study aimed to describe the real‐life incidence of bleeding, arterial thrombotic events and death during vitamin K antagonist (VKA) treatment in atrial fibrillation (AF).MethodsThis was a cohort study in Echantillon Généraliste de Bénéficiaires, the 1/97 sample of the French national healthcare claims and hospitalization database, of new VKA users with definite or probable AF and no other indication, and of patients without AF, from 2007 to 2011. Prespecified outcomes were all‐cause death, hospitalization for bleeding, arterial thrombotic event (ATE), or acute coronary syndrome (ACS) or any of the above (composite outcome).ResultsOf 8894 new VKA users, 3345 had probable or certain AF, 51.7% were male, mean age was 75.1 years, 87.1% had a CHA2DS2‐VASc score ≥ 2 and 11.6% a HAS‐BLED score > 3. Among AF patients, during VKA exposure the incidence rate of bleeding was 2.8 [95% confidence interval (CI) 2.2, 3.4] per 100 patient‐years, including 0.6 (95% CI 0.3, 0.8) cerebral, 1.0 (95% CI 0.7, 1.3) digestive and 1.4 (95% CI 1.0, 1.7) other bleeds. There were 1.6 (95% CI 1.2, 2.0) ACS, 1.5 (95% CI 1.1, 1.8) ATE and 3.8 (95% CI 3.2, 4.4) deaths per 100 patient‐years. The incidence rate of the composite outcome was 9.1 per 100 patient‐years (95% CI 8.2, 10.0). When patients stopped VKA, bleeding decreased (RR 0.67, 95% CI 0.43, 1.04)), but death or thrombosis increased (RR 3.06, 95% CI 2.46, 3.81 and 1.75, 95% CI 1.14, 2.70, respectively). During VKA exposure non‐AF patients had similar rates of bleeding, but fewer deaths, ACS and ischaemic events.ConclusionsReal‐life rates for bleeding, arterial thrombotic events, ACS and deaths in AF patients treated with VKA were similar to those observed in clinical trials.
Recent advances in the management of AL Amyloidosis
Authors: Kastritis Efstathios , Dimopoulos Meletios A. 
Published: October 2015

SummaryImmunoglobulin light chain (AL) amyloidosis, the most common of the systemic amyloidosis, is characterized by the deposition of amyloid fibrils that derive from the aggregation of misfolded monoclonal immunoglobulin light chains. Amyloid fibrils disrupt tissue architecture and the pre‐fibril oligomers are directly toxic to myocardiac cells, causing cardiac dysfunction. The lethal consequences of AL amyloidosis are due to the toxic product and not due to the malignant behaviour of the plasma cell clone; however, the characteristics of this clone are associated with long‐term prognosis. Early and accurate diagnosis is the key to effective management, but is challenging. Modern chemotherapy options (including autologous transplantation, bortezomib, lenalidomide) have improved the outcomes of patients at low or intermediate risk, but the prognosis of patients with severe cardiac dysfunction is still poor. Therapies targeting amyloid deposits and the amyloidogenic process are under investigation and offer promise for better future treatments.
Laboratory measurement of the direct oral anticoagulants
Authors: Dale Brian J. , Chan Noel C. , Eikelboom John W. 
Published: October 2015

SummaryDirect oral anticoagulants (DOACs), including the direct thrombin inhibitor, dabigatran, and the direct factor Xa (FXa) inhibitors, rivaroxaban, apixaban and edoxaban, are approved for thromboembolism prevention and treatment. These drugs do not require routine coagulation monitoring but, in some circumstances, measurement of drug level or anticoagulant effect may be necessary. Although traditional coagulation tests lack analytical sensitivity and specificity, they are widely available and inexpensive, and can provide useful information regarding the residual anticoagulant effect of DOACs. Hemoclot® and ecarin‐based assays can be used to quantify dabigatran level and calibrated chromogenic anti‐FXa assays are suitable for measuring rivaroxaban, apixaban and edoxaban levels, but these tests are not yet widely available.
PhaseIItrial of R‐CHOPplus bortezomib induction therapy followed by bortezomib maintenance for newly diagnosed mantle cell lymphoma:SWOGS0601
Authors: Till Brian G. , Li Hongli , Bernstein Steven H. , Fisher Richard I. , Burack W. Richard , Rimsza Lisa M. , Floyd Justin D. , DaSilva Marco A. , Moore Dennis F. , Pozdnyakova Olga , Smith Sonali M. , LeBlanc Michael , Friedberg Jonathan W. 
Published: October 2015

SummaryBortezomib is active in mantle cell lymphoma (MCL), with approval in upfront and relapsed settings. Given inevitable recurrence following induction chemoimmunotherapy, maintenance approaches are a rational strategy to improve clinical outcomes. We conducted a phaseIIstudy to evaluate the safety and efficacy of six cycles of R‐CHOP(rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) plus bortezomib (1·3 mg/m2days 1 and 4 of 21 d cycles) followed by bortezomib maintenance (1·3 mg/m2days 1, 4, 8, and 11 every 3 months for 2 years). Sixty‐five eligible patients were enrolled. The treatment was well tolerated and toxicities were mainly haematological. The rate of grade ≥3 peripheral neuropathy was low (5%). With a median follow‐up of 6·8 years, 2‐year progression‐free survival (PFS) was 62%, and 2‐year overall survival (OS) was 85%. At 5 years,PFSwas 28% andOSwas 66%.MCLInternational Prognostic Index scores were significantly associated with 2‐yearPFS, but did not predict long‐term (≥5‐year)PFS. Baseline Ki‐67 index was significantly associated with survival. Combination R‐CHOPwith bortezomib followed by maintenance bortezomib appears to improve outcomes compared historically with R‐CHOPalone, with prolonged remissions in a subset of patients. These results suggest that inclusion of bortezomib with induction chemotherapy and/or maintenance is promising inMCLand warrants further exploration.
Minimal residual disease assessed by multi‐parameter flow cytometry is highly prognostic in adult patients with acute lymphoblastic leukaemia
Authors: Ravandi Farhad , Jorgensen Jeffrey L. , O'Brien Susan M. , Jabbour Elias , Thomas Deborah A. , Borthakur Gautam , Garris Rebecca , Huang Xuelin , Garcia‐Manero Guillermo , Burger Jan A. , Ferrajoli Alessandra , Wierda William , Kadia Tapan , Jain Nitin , Wang Sa A. , Konoplev Sergei , Kebriaei Partow , Champlin Richard E. , McCue Deborah , Estrov Zeev , Cortes Jorge E. , Kantarjian Hagop M. 
Published: October 2015

SummaryThe prognostic value of minimal residual disease (MRD) assessed by multi‐parameter flow cytometry (MFC) was investigated among 340 adult patients with B‐cell acute lymphoblastic leukaemia (B‐ALL) treated between 2004 and 2014 using regimens including the hyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone, methotrexate, cytarabine) backbone. Among them, 323 (95%) achieved complete remission (CR) and were included in this study. Median age was 52 years (range, 15–84). Median white blood cell count (WBC) was 9·35 × 109/l (range, 0·4–658·1 ×1 09/l). MRD by MFC was initially assessed with a sensitivity of 0·01%, using a 15‐marker, 4‐colour panel and subsequently a 6‐colour panel on bone marrow specimens obtained at CR achievement and at approximately 3 month intervals thereafter. MRD negative status at CR was associated with improved disease‐free survival (DFS) and overall survival (OS) (P = 0·004 and P = 0·03, respectively). Similarly, achieving MRD negative status at approximately 3 and 6 months was associated with improved DFS (P = 0·004 and P < 0·0001, respectively) and OS (P = 0·004 and P < 0·0001, respectively). Multivariate analysis including age, WBC at presentation, cytogenetics (standard versus high risk) and MRD status at CR, 3 and 6 months, indicated that MRD negative status at CR was an independent predictor of DFS (P < 0·05). Achievement of an MRD negative state assessed by MFC is an important predictor of DFS and OS in adult patients with ALL.