bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digitally Enhanced Psychological Assessment and Treatment of Paranoia: A Systematic Review
Authors: Bird Molly , O'Neill Emma , Riches Simon 
Published: June 2024

ABSTRACTBackgroundParanoia is relatively common but can lead to significant distress, impairment and need for care. Digital technologies offer a valuable extension to service provision and are increasingly being integrated into healthcare. This systematic review evaluated feasibility, acceptability, and effectiveness of digitally enhanced psychological assessments and treatments for paranoia across the paranoia continuum (PROSPERO: CRD42023393257).MethodsDatabases PsychINFO, EMBASE, MEDLINE and Web of Science were searched until 12 June 2023; the Effective Public Health Practice Project (EPHPP) quality assessment tool evaluated studies; and a narrative synthesis was conducted.ResultsTwenty‐seven studies met inclusion criteria (n = 3457, 23 assessment and 4 treatment, 2005–2023, most in Europe). Technologies included virtual reality (VR, n = 23), experience sampling methodology (ESM, n = 2), an app (n = 1) and a combination of VR and ESM (n = 1). Assessments involved monitoring paranoia under various virtual conditions or in everyday life. Treatments were generally integrated with Cognitive Behaviour Therapy (CBT), which involved using VR to test out threat beliefs and drop safety behaviours or using an app to support slowing down paranoid thinking. EPHPP ratings were strong (n = 8), moderate (n = 12) and weak (n = 7).ConclusionsDigitally enhanced assessments and treatments showed promising acceptability, feasibility and treatment effectiveness. Limitations of studies include small sample sizes, lack of comparison groups and long‐term data and limited randomised controlled trials. Results support the potential future integration of VR in the assessment of paranoia and show promise for treatments such as CBT, although further clinical trials are required. Investigation of other technologies is limited.
Differential retinoic acid sensitivity of oral and pharyngeal teeth in medaka (Oryzias latipes) supports the importance of pouch–cleft contacts in pharyngeal tooth initiation
Authors: Larionova D. , Huysseune A. 
Published: June 2024

AbstractBackgroundPrevious studies have claimed that pharyngeal teeth in medaka (Oryzias latipes) are induced independent of retinoic acid (RA) signaling, unlike in zebrafish (Danio rerio). In zebrafish, pharyngeal tooth formation depends on a proper physical contact between the embryonic endodermal pouch anterior to the site of tooth formation, and the adjacent ectodermal cleft, an RA‐dependent process. Here, we test the hypothesis that a proper pouch–cleft contact is required for pharyngeal tooth formation in embryonic medaka, as it is in zebrafish. We used 4‐[diethylamino]benzaldehyde (DEAB) to pharmacologically inhibit RA production, and thus pouch–cleft contacts, in experiments strictly controlled in time, and analyzed these using high‐resolution imaging.ResultsPharyngeal teeth in medaka were present only when the corresponding anterior pouch had reached the ectoderm (i.e., a physical pouch–cleft contact established), similar to the situation in zebrafish. Oral teeth were present even when the treatment started approximately 4 days before normal oral tooth appearance.ConclusionsRA dependency for pharyngeal tooth formation is not different between zebrafish and medaka. We propose that the differential response to DEAB of oral versus pharyngeal teeth in medaka could be ascribed to the distinct germ layer origin of the epithelia involved in tooth formation in these two regions.
The Integration of Sleep Research Into Eating Disorders Research: Recommendations and Best Practices
Authors: Irish Leah A. , Bottera Angeline R. , Manasse Stephanie M. , Christensen Pacella Kara A. , Schaefer Lauren M. 
Published: June 2024

ABSTRACTObjectiveSleep disturbance is common among individuals with eating disorders (EDs), with approximately 50% of patients with EDs reporting sleep disturbance. Sleep problems may promote, exacerbate, or maintain ED symptoms through a variety of hypothesized mechanisms, such as impaired executive function, increased negative affect, and disruptions to appetitive rhythms. Although research investigating the role of sleep in EDs is growing, the current literature suffers from methodological limitations and inconsistencies, which reduce our ability to translate findings to improve clinical practice. The purpose of this forum is to propose a coordinated approach to more seamlessly integrate sleep research into ED research with particular emphasis on best practices in the definition and assessment of sleep characteristics.MethodsIn this article, we will describe the current status of sleep‐related research and relevant gaps within ED research practices, define key sleep characteristics, and review common assessment strategies for these sleep characteristics. Throughout the forum, we also discuss study design considerations and recommendations for future research aiming to integrate sleep research into ED research.Results/DiscussionGiven the potential role of sleep in ED maintenance and treatment, it is important to build upon preliminary findings using a rigorous and systematic approach. Moving forward as a field necessitates a common lens through which future research on sleep and EDs may be conducted, communicated, and evaluated.
Numerical investigations of earthquake resilient beam‐to‐column joints with replaceable BRFCPs using different restraint plates
Authors: Feng Yulong , Li Chaonan , Zhang Zhi , Jiang Qing , Chong Xun 
Published: June 2024

AbstractA replaceable buckling‐restrained flange cover plate (BRFCP) was previously proposed to improve seismic performance of beam‐to‐column joints. Quasi‐static tests were conducted to investigate the seismic performance of beam‐to‐column joints using three different formats of restraint plates for BRFCP: no restraint plate, separated restraint plate, and integral restraint plate. The test results showed that both separated and integral restraint plates restrained the core plate buckling under compression and increased the beam‐to‐column joints load resistances. This paper first validates finite element models (FEMs) using test results. Then the validated FEMs are used to investigate influences from different BRFCP design parameters (such as core plate thickness, restraint plate thickness and length, restraining gap size, and restraint plate blot prestress force) to the beam‐to‐column joint load–drift hysteretic responses. Finally, the paper proposes a design range of each investigated design parameter and a BRFCP design procedure.
Global trends in heart failure from 1990 to 2019: An age‐period‐cohort analysis from the Global Burden of Disease study
Authors: Liu Zeye , Li Ziping , Li Xinqing , Yan Yiming , Liu Jinyang , Wang Jing , Guan Jingyuan , Xin Anran , Zhang Fengwen , Ouyang Wenbin , Wang Shouzheng , Xia Ruibing , Li Yakun , Shi Yi , Xie Jing , Zhang Yuhui , Pan Xiangbin 
Published: June 2024

AbstractAimsThis study aimed to analyse the global prevalence and disability trends of heart failure (HF) from 1990 to 2019, considering both sexes and country‐specific economic strata.MethodsThis study conducted a secondary analysis employing data from the Global Burden of Disease (GBD) study. The analysis is stratified by sex and Socio‐demographic Index (SDI) levels. Through age‐period‐cohort and Joinpoint regression analyses, we investigated the temporal trends in HF prevalence and years lived with disability (YLDs) during this period.ResultsBetween 1990 and 2019, the global prevalence of HF surged by 106.3% (95% uncertainty interval: 99.3% to 114.3%), reaching 56.2 million cases in 2019. While all‐age prevalence and YLDs increased over the 30 year span, age‐standardized rates decreased by 2019. Countries with higher SDI experienced a more pronounced percentage decrease compared with those with lower SDI. Longitudinal analysis revealed an overall improvement in both prevalence and YLDs for HF, albeit with notable disparities between SDI quintiles and sexes. Ischaemic heart disease and hypertensive heart disease emerged as the most rapidly increasing and primarily contributing causes of HF, albeit with variations observed across different countries. The average annual percentage change for prevalence and YLDs over the period was −0.26% and −0.25%, respectively.ConclusionsThis study offers valuable insights into the global burden of HF, considering factors such as population aging, regional disparities, sex differences and aetiological variations. The findings hold significant implications for healthcare planning and resource allocation. Continued assessment of these trends and innovative strategies for HF prevention and management are crucial for addressing this pressing global health concern.
Proposal and performance evaluation of a new parallel plate continuous cell separation device using dielectrophoresis
Authors: Seki Yoshinori , Nagasaka Aoi , Gondo Tsukushi , Tada Shigeru 
Published: June 2024

AbstractAlong with the rapid development of cellular biological research in recent years, there has been an urgent need for a high‐speed, high‐precision method of separating target cells from a highly heterogeneous cell population. Among the various cell separation technologies proposed so far, dielectrophoresis (DEP)‐based approaches have shown particular promise because they are noninvasive to cells. We have developed a new DEP‐based device to separate large numbers of live and dead cells of the human mammary cell line MCF10A. In this study, we validated the separation performance of this device. The results showed the successful separation of a higher percentage of cells than in previous studies, with a separation efficiency higher than 90%. In the past, there have been no confirmed cases in which a separation rate of over 90% and high‐speed processing of a large number of cells were simultaneously achieved. It was shown that the proposed device can process large numbers of cells at high speed and with high accuracy.
Statistics to prioritize rare variants in family‐based sequencing studies with disease subtypes
Authors: Nieuwoudt Christina , Farooq Fabiha Binte , Brooks‐Wilson Angela , Bureau Alexandre , Graham Jinko 
Published: June 2024

AbstractFamily‐based sequencing studies are increasingly used to find rare genetic variants of high risk for disease traits with familial clustering. In some studies, families with multiple disease subtypes are collected and the exomes of affected relatives are sequenced for shared rare variants (RVs). Since different families can harbor different causal variants and each family harbors many RVs, tests to detect causal variants can have low power in this study design. Our goal is rather to prioritize shared variants for further investigation by, for example, pathway analyses or functional studies. The transmission‐disequilibrium test prioritizes variants based on departures from Mendelian transmission in parent–child trios. Extending this idea to families, we propose methods to prioritize RVs shared in affected relatives with two disease subtypes, with one subtype more heritable than the other. Global approaches condition on a variant being observed in the study and assume a known probability of carrying a causal variant. In contrast, local approaches condition on a variant being observed in specific families to eliminate the carrier probability. Our simulation results indicate that global approaches are robust to misspecification of the carrier probability and prioritize more effectively than local approaches even when the carrier probability is misspecified.
Telerehabilitation improves cardiorespiratory and muscular fitness and body composition in older people with post‐COVID‐19 syndrome
Authors: Pleguezuelos Eulogio , Del Carmen Amin , Moreno Eva , Serra‐Prat Mateu , Serra‐Payá Noemí , Garnacho‐Castaño Manuel Vicente 
Published: June 2024

AbstractBackgroundThe effects of post‐coronavirus disease 2019 (COVID‐19) syndrome on the cardiorespiratory and muscular fitness in older people are of utmost relevance. This study aimed to evaluate the effects of a 12‐week telerehabilitation programme on cardiorespiratory and muscular fitness and body composition in older patients with post‐COVID‐19 syndrome.MethodsOne hundred twenty older patients with post‐COVID‐19 syndrome were randomly assigned to one of two groups: patients who carried out the telerehabilitation programme (n = 60; age: 65.0 ± 5.2; female: 14.2%) and a control group (n = 60; age: 64.3 ± 5.0; female: 24.5%). An incremental cardiopulmonary exercise testing, isokinetic strength test, and bioelectrical impedance analysis were performed to compare cardiorespiratory and muscle strength responses and body composition between telerehabilitation and control groups.ResultsA significant increase in the cardiopulmonary exercise testing duration was found in the telerehabilitation group compared to the control group (mean difference = 88.9 s, P = 0.001). Peak oxygen uptake increased in the telerehabilitation group (mean difference = 3.0 mL·kg−1·min−1, P < 0.001) and control group (mean difference = 1.9 mL·kg−1·min−1, P < 0.001). Power output in cycle ergometer (mean difference = 25.9 watts, P < 0.001), fat free mass (mean difference = 2.1 kg, P = 0.004), soft lean mass (mean difference = 2.1 kg, P = 0.003), and skeletal muscle mass (mean difference = 1.4 kg, P = 0.003) only increased in the telerehabilitation group. A significant increase in the power output was observed in the telerehabilitation group compared with the control group in both lower limbs after isokinetic strength test of the leg extension at a speed of 60° (right: mean difference = 18.7 watts, P = 0.012; left: mean difference = 15.3 watts, P = 0.010). The peak torque of right leg extension increased only in the telerehabilitation group after isokinetic strength test at a speed of 60° (mean difference = 13.1 N·m, P < 0.001). A significant increase in the power output was observed in the telerehabilitation group compared with the control group in the left leg extension after isokinetic strength test at a speed of 180° (mean difference = 30.2 watts, P = 0.003).ConclusionsThe telerehabilitation programme improved cardiorespiratory and muscular fitness, and body composition in older patients with post‐COVID‐19 syndrome to a greater extent than a control group. The telerehabilitation programmes may be an alternative to improve the sequelae of post‐COVID‐19 syndrome in older patients.
The distribution of parent‐reported autistic and subclinical ADHD traits in children with and without an autism diagnosis
Authors: Chau Tracey , Tiego Jeggan , Brown Louise E. , Mellahn Olivia J. , Johnson Beth P. , Bellgrove Mark A. 
Published: June 2024

AbstractBackgroundAttention‐deficit/hyperactivity disorder (ADHD) traits often co‐occur in autistic children. The presence of subclinical ADHD traits can significantly impact upon different aspects of daily living. As such, understanding the distribution of these traits in autistic children may have important implications for the validity of diagnostic tools and subsequent intervention choices. This study builds on previous latent models of parent‐reported autistic and ADHD traits to propose a preliminary model of their distribution in two independent samples of autistic and neurotypical children.MethodsFactor mixture modelling was applied to caregiver responses to the Social Responsiveness Scale ‐ 2nd edition and the Strengths and Weaknesses of ADHD Symptoms and Normal Behaviour Scale (SWAN) of participants aged 4–18 years who participated in one of two studies in Australia or in the United States.ResultsA 2‐factor, 3‐class factor mixture model demonstrated the best fit to the data across both independent samples. The factors represented the latent constructs of ‘autism’ and ‘ADHD’. The latent classes represented subtypes of children with different levels of autistic traits, with higher levels of ADHD traits as autistic trait endorsement increased. Some sample‐specific differences were observed for each model's item thresholds and factor covariance matrices.ConclusionsOur findings suggest that the endorsement of subclinical ADHD traits tends to increase alongside autistic trait endorsement across neurotypical and autistic presentations. There may be clinical utility in routinely screening for ADHD traits in children with clinically elevated levels of autistic traits.
Ethyl pyruvate alleviates NLRP3/Caspase‐1/GSDMD‐mediated neuronal pyroptosis in neonatal rats with hypoxic–ischemic brain damage
Authors: Sha Sha , Jin Ni , Xie Xinyi , Zhou Ruiyu , Ruan Yanghao , Ouyang Ying 
Published: June 2024

AbstractPyroptosis is an inflammation‐associated programmed cell death, and neuroinflammation is strongly associated with severe neurological deficits in neonatal hypoxic–ischemic encephalopathy (HIE). Ethyl pyruvate (EP), a known anti‐inflammatory agent, has shown promise in the treatment of hypoxic–ischemic brain damage (HIBD) rats; nevertheless, the therapeutic mechanism of EP and its capacity to suppress neuronal pyroptosis in HIBD rats remain unclear. In both the neonatal Rice‐Vannucci rat model and the OGD/R model, this study examined alterations in the NLRP3/Caspase‐1/GSDMD classical pyroptosis pathway in hippocampal neurons during HIE and the potential inhibitory impact of ethyl pyruvate on this pathway. We used HE staining, immunofluorescence double staining, transmission electron microscopy, and western blot to demonstrate that EP effectively inhibited hippocampal neuronal pyroptosis and attenuated the activation of the NLRP3/Caspase‐1/GSDMD signaling pathway in HIBD rats, which resulted in a reduction of neuroinflammation and facilitated neural recovery. The results suggest that EP may be a promising neuroprotective agent for treating HIE.
An exploration of psychological safety and conflict in first‐year engineering student teams
Authors: Huerta Mark Vincent , Sajadi Susan , Schibelius Lisa , Ryan Olivia Jane , Fisher Marin 
Published: June 2024

AbstractBackgroundDeveloping teamwork skills is a central objective of engineering education. Psychological safety and conflict management are pivotal components of teamwork, yet despite their significance, research in engineering project‐based learning (PBL) contexts is scant. Understanding students' experiences with psychological safety and its interaction with conflict is crucial to inform PBL pedagogy.PurposeThis study delves into first‐year engineering students' experiences of psychological safety and conflict, including their evolution in a PBL course.MethodsThroughout the semester, we collected data from 82 students via written reflections and focus groups. Employing a thematic analysis underpinned by the team conflict dynamics model, we characterized students' experiences with psychological safety and conflict.FindingsAt the semester's outset, psychological safety was notably lacking. Students often hesitated to share ideas due to apprehensions about peer reactions and fears of negative judgments. As the semester advanced, consistent positive affirmations nurtured psychological safety, increasing students' confidence and readiness to discuss ideas openly and engage in healthy task conflict. Notably, process conflicts arising from absenteeism, poor communication, and procrastination were prevalent across teams. When unresolved, these conflicts eroded psychological safety, intensifying stress, exacerbating frustrations, and provoking relationship conflict.ConclusionsOur study underscores the intertwined nature of psychological safety and conflict in shaping the first‐year design experience in student teams. We urge faculty to recognize their pivotal role in fostering an inclusive culture and highlight pedagogical strategies that can bolster psychological safety at the onset, encourage healthy task conflict, and monitor unhealthy process and relationship conflicts.
Riboflavin transporter deficiency in young adults unmasked by dietary changes
Authors: Jaeger Bregje , Langeveld Mirjam , Brunkhorst Robert , Distelmaier Felix , Pop Ana , Wolf Nicole I. , Bosch Annet M. 
Published: June 2024

AbstractRiboflavin transporter deficiency (RTD) is a genetic disorder of reduced riboflavin (vitamin B2) uptake that causes progressive, multifocal neurological dysfunction. Most patients present in early childhood; if patients present later in life, symptoms usually develop more gradually. We report three previously healthy young adults, who developed rapidly progressive neurological symptoms after decreasing dietary intake of meat and dairy. After a diagnostic odyssey, the diagnosis of a riboflavin transporter deficiency was made. Treatment with high dose oral riboflavin (20–40 mg/kg/day) partially reversed symptoms. This case series highlights that reduced riboflavin intake as a result of dietary changes can unmask RTD at a later age. We emphasize the importance of early recognition of this progressive and potentially lethal disease and show that timely treatment with high dose riboflavin is highly effective.
It's my business! The influence of psychological ownership on entrepreneurial intentions and work performance
Authors: Hamrick Alexander B. , Burrows Sarah , Waddingham Jacob A. , Crossley Craig D. 
Published: June 2024

SummaryExtant scholarship on psychological ownership has primarily focused on the organizational benefits that come from fostering employees' feelings of ownership without having to relinquish ties to actual ownership. It is unclear, however, if feeling like an owner is sufficient to satisfy employees' aspirational ownership intentions. By applying self‐verification theory to psychological ownership theory, we investigate how employees' psychological ownership influences their views about being a competent business owner, and the potential double‐edged implications for organizations as a result of these self‐views. Utilizing two separate studies, we find that psychological ownership is positively associated with entrepreneurial self‐efficacy, which, in turn, is positively associated with both entrepreneurial intentions and work performance. Furthermore, results show that employees' past work performance strengthens the positive relationship between psychological ownership and entrepreneurial self‐efficacy and the positive indirect relationship between psychological ownership and entrepreneurial intentions through entrepreneurial self‐efficacy. We discuss the theoretical and practical implications of fostering psychological ownership with current employees to glean the benefits and negate any potential drawbacks, such as high performers leaving the organization to start their own business.