bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and clinical course of femoral localized periosteal thickening and atypical femoral fracture over a 10-year period in patients with autoimmune inflammatory rheumatic disease
Authors: Sato Hiroe , Kondo Naoki , Kurosawa Yoichi , Hasegawa Eriko , Wakamatsu Ayako , Nozawa Yukiko , Kobayashi Daisuke , Nakatsue Takeshi , Wada Yoko , Kazama Junichiro James , Kuroda Takeshi , Nakano Masaaki , Endo Naoto , Narita Ichiei 
Published: July 2024

Abstract
Atypical femoral fracture (AFF) is generally a rare complication of long-term use of bisphosphonate (BP); glucocorticoid (GC) use and Asian race are also risk factors. Femoral localized periosteal thickening (LPT, also termed “beaking”) of the lateral cortex often precedes AFF. This cohort study investigated the incidence of LPT and AFF and their clinical courses over 10 yr in patients with autoimmune inflammatory rheumatic diseases (AIRDs) treated with BP and GC. The study population consisted of 121 patients with AIRDs taking BP and GC. LPT was screened by X-ray, and the LPT shape was evaluated. Prednisolone (PSL) dose was 10 (8–12) mg/d at enrollment and 9 (6–10) mg/d at the last observation. LPT was evident in 10 patients at enrollment and increased linearly to 31 patients (26%) at the last observation. AFF occurred in 9 femurs of 5 patients with LPT. All patients with AFF had bilateral LPT, and the prevalence of pointed type and LPT height were higher in the AFF-positive group than in the AFF-negative group. AFF occurred before BP discontinuation in 2 patients, 1 yr after BP discontinuation in 1, after BP discontinuation followed by 7 yr of alfacalcidol use in 1, and after switching from alfacalcidol to denosumab in 1. The prevalence rates of AFF and LPT associated with long-term BP use with concomitant use of GC (mostly PSL ≥ 6 mg/d) in Japanese patients with AIRD increased over time. The selection of long-term osteoporosis treatment for LPT-positive patients is difficult in some cases.
Identification and prioritization of patient-centred strategies to enhance IBD-related care for older adults: a modified Delphi approach
Authors: Rohatinsky Noelle , Tooke Natasha , Fowler Sharyle , Rueda-Clausen Christian , Morrison Dirk , Winchester Judith , Peña-Sánchez Juan-Nicolás 
Published: July 2024

Abstract

Background
The older adult age group makes up one of the fastest-growing groups of individuals with inflammatory bowel disease (IBD). It is important to hear the perspectives of older adults living with IBD about care experiences and managing their illness. The purpose of this patient-oriented study was to identify and prioritize patient-centred strategies that have the potential to enhance IBD-related care for older adults in Saskatchewan.

Methods
The interprofessional research team, consisting of older adult individuals living with IBD, gastroenterology providers, and researchers specializing in IBD or older adult education used a modified Delphi approach to identify and prioritize strategies that may enhance IBD-related care for older adults. Thirty-one older adults with IBD participated in ranking, revising, and prioritizing statements related to their chronic illness care. Nine statements were developed that highlighted strategies for older adult IBD care.

Results
Through the consensus process, 6 statements were retained. Co-creating a treatment plan with the IBD provider was ranked as the top priority statement for older adults with IBD.

Conclusion
Facilitating collaborative relationships and understanding individual priorities for IBD-related care for older adults has the potential to enhance positive health outcomes and quality of life for these individuals.
Gomeza serrataDana, 1852 is a trichopeltariid, not a corystid, and a junior synonym ofPeltarion spinosulus(White, 1843) (Decapoda: Brachyura: Trichopeltarioidea)
Authors: Ng Peter K L , Tavares Marcos 
Published: July 2024

AbstractThe corystid Gomeza serrata Dana, 1852, described from Patagonia in South America has rarely been reported and its taxonomy is poorly understood. While superficially similar to G. bicornisGray, 1831 from the Indo-West Pacific and the type species of Gomeza Gray, 1931, direct comparisons have not been recorded. Examination of topotypic specimens show that Gomeza serrata is actually a juvenile of Peltarion spinosulus (White, 1843), a member of the family Trichopeltariidae. A neotype is selected for G. serrata to stabilize its taxonomy.
Substructure-based topology optimization design method for passive constrained damping structures
Authors: Wu Zijun , Xiao Renbin , Xiao Xiaofeng 
Published: July 2024

Abstract
This work presents a generalized substructure-based topology optimization method for passive constrained layer damping (PCLD) structures. Here, the model of PCLD structure is obtained by the Kirchhoff–Love thin plate formulation, and the whole structure is assumed to be composed of substructures with different yet connected scales and artificial lattice geometry features. Each substructure is condensed into a super-element to obtain the associated density-related matrices under the different geometry feature parameters, and the surrogate model for the stiffness and mass matrix of PCLD substructures with different densities has been particularly built. Using cubic spline interpolation, the derivatives of super-element matrices to the associated densities can be evaluated efficiently and accurately. The modal loss factor is defined as objective functions and topology optimization for the PCLD structures is formulated based on the model for PCLD plates that are described by combining the condensed substructures. Numerical examples under two lattice patterns of substructures and their corresponding physical tests show that the correctness and superiority of this substructure-based topology optimization approach for PCLD plates are verified.
How Numerical Cognition Explains Ambiguity Aversion
Authors: Lenkovskaya Marina , Sweldens Steven 
Published: July 2024

Abstract
Consumers generally prefer precise probabilities or outcomes over imprecise ranges with the same expected value, a bias known as “ambiguity aversion.” We argue that two elementary principles of numerical cognition explain great heterogeneity in this bias, affecting consumer choices in many domains where options are characterized by varying levels of uncertainty (e.g., lotteries, discounts, investment products, vaccines, etc.). The first principle, the “compression effect,” stipulates that consumers’ mental number lines are increasingly compressed at greater number magnitudes. This alone suffices to predict ambiguity aversion as it causes a midpoint (e.g., $40) to be perceived as closer to the upper bound of a range (e.g., $60) compared to its lower bound (e.g., $20). Furthermore, as the compression effect distorts the mental number line especially at lower numbers, it follows that ambiguity aversion should decrease around greater numbers. The second principle, the “left-digit effect” causes a range’s relative attractiveness to decrease (increase) disproportionately with every left-digit transition in its lower (upper) bound, thus increasing (decreasing) ambiguity aversion. Due to the overall compression effect, the impact of the left-digit effect increases at greater numbers. We present 34 experiments (N = 10,634) to support the theory’s predictions and wide applicability.
Hydroxyurea in Sickle Cell Disease and Invasive Bacterial Infections: A Case–Control Study
Authors: Pascault Alice , Koehl Bérengère , Brousse Valentine , Benkerrou Malika , Gaschignard Jean 
Published: July 2024

Abstract
Hydroxyurea decreases painful events among children with sickle cell disease (SCD) but could increase the risk of infections in treated patients through leucopenia. We performed a case–control study, comparing hydroxyurea treatment for SCD in cases with an invasive bacterial infection and in controls without infection. No difference was found.
Isolated traumatic triceps tendon rupture following a motorcycle accident: a case report
Authors: Argueta Victor H , Saenz Daniela , Ardebol Javier 
Published: July 2024

Abstract
Triceps tendon ruptures are rare but significant injuries that impair upper extremity function. Despite their infrequency, recognizing this condition is crucial due to its severe impact on arm movement and strength. Patients typically present with posterior elbow pain, swelling, and bruising.This report details a complete triceps tendon rupture in a 34-year-old male following trauma. The patient exhibited classic symptoms: posterior elbow pain, significant swelling, and visible bruising, initially suggesting a severe soft tissue injury. Clinical examination and imaging confirmed a complete triceps tendon rupture. This case highlights the importance of considering triceps tendon rupture in patients with similar symptoms, particularly after trauma. Early recognition and accurate diagnosis are essential for timely surgical intervention, significantly improving functional recovery. Delayed diagnosis and treatment can lead to prolonged disability and poor outcomes, emphasizing the need for heightened awareness among healthcare providers regarding this rare but serious injury.
Cash Cows and Dogs with Dentures: Prostheses for Animals in Nineteenth-Century British Culture
Authors: Sweet Ryan 
Published: July 2024

Abstract
This article shows how the history of prostheticized animals is much deeper and richer than one might think. Investigating the interest in fitting animals with prostheses throughout the nineteenth century in Britain, this article explores the emergence of animal prostheses in bovine agriculture through to their use in late Victorian pet keeping. The key concern of this piece is the varied responses to prostheticized animals in print culture. As this article shows through an analysis of magazine and newspaper contributions, reactions to animal prostheses varied from admiration and amazement to annoyance and disgust. By analysing this coverage, the article reveals how representations of animal prostheses brought into collision a surprising variety of important social discourses, including those related to economic productivity, prosthesis access, food adulteration, professional recognition, social norms, class hierarchies, and gender relations. Animal prostheses proved a novel yet apt image that distilled a wide variety of societal concerns. Redirecting the critical momentum established by recent scholarship that unites disability studies and critical animal studies, this article uses nineteenth-century animal prostheses as a case study to demonstrate how the concepts of disability, ableism, classism, and misogyny have been extended by humans across species boundaries and how our approaches to nonhuman care are impacted by them. It therefore establishes a new field of inquiry within Victorian studies for scholarship on the interface between discourses of disability and nonhuman animals.
Differences in stomatal sensitivity to CO2 and light influence variation in water use efficiency and leaf carbon isotope composition in two genotypes of the C4 plant Zea mays
Authors: Crawford Joseph D , Twohey Robert J , Pathare Varsha S , Studer Anthony J , Cousins Asaph B 
Published: July 2024

Abstract
The ratio of net CO2 uptake (Anet) and stomatal conductance (gs) is an intrinsic measurement of leaf water use efficiency (WUEi); however, its measurement can be challenging for large phenotypic screens. Measurements of the leaf carbon isotope composition (δ13Cleaf) may be a scalable tool to approximate WUEi for screening because it in part reflects the competing influences of Anet and gs on the CO2 partial pressure (pCO2) inside the leaf over time. However, in C4 photosynthesis, the CO2-concentrating mechanism complicates the relationship between δ13Cleaf and WUEi. Despite this complicated relationship, several studies have shown genetic variation in δ13Cleaf across C4 plants. Yet there has not been a clear demonstration of if Anet or gs are the causal mechanisms controlling WUEi and δ13Cleaf. Our approach was to characterize leaf photosynthetic traits of two Zea mays recombinant inbred lines (Z007E0067 and Z007E0150) which consistently differ for δ13Cleaf even though they have minimal confounding genetic differences. We demonstrate that these two genotypes contrasted in WUEi driven by differences in the speed of stomatal responses to changes in pCO2 and light that lead to unproductive leaf water loss. These findings provide support that differences in δ13Cleaf in closely related genotypes do reflect greater WUEi and further suggest that differences in stomatal kinetic response to changing environmental conditions is a key target to improve WUEi.
Plant chromosome polytenization contributes to suppression of root growth in high polyploids
Authors: Kikuchi Suzuka , Sakamoto Takuya , Matsunaga Sachihiro , Sugiyama Munetaka , Iwamoto Akitoshi 
Published: July 2024

Abstract
Autopolyploidization, which refers to a polyploidization via genome duplication without hybridization, promotes growth in autotetraploids, but suppresses growth in high polyploids (autohexaploids or auto-octoploids). The mechanism underlying this growth suppression (i.e. ‘high-ploidy syndrome’) has not been comprehensively characterized. In this study, we conducted a kinematic analysis of the root apical meristem cells in Arabidopsis thaliana autopolyploids (diploid, tetraploid, hexaploid, and octoploid) to determine the effects of the progression of genome duplication on root growth. The results of the root growth analysis showed that tetraploidization increases the cell volume, but decreases cell proliferation. However, cell proliferation and volume growth are suppressed in high polyploids. Whole-mount fluorescence in situ hybridization analysis revealed extensive chromosome polytenization in the region where cell proliferation does not usually occur in the roots of high polyploids, which is likely to be at least partly correlated with the suppression of endoreduplication. The study findings indicate that chromosome polytenization is important for the suppressed growth of high polyploids.
Root plasticity improves maize nitrogen use when nitrogen is limiting: an analysis using 3D plant modelling
Authors: Lu Jie , Lankhost Jan A , Stomph Tjeerd Jan , Schneider Hannah M , Chen Yanling , Mi Guohua , Yuan Lixing , Evers Jochem B 
Published: July 2024

Abstract
Plant phenotypic plasticity plays an important role in nitrogen (N) acquisition and use under nitrogen-limited conditions. However, this role has never been quantified as a function of N availability, leaving it unclear whether plastic responses should be considered as potential targets for selection. A combined modelling and experimentation approach was adopted to quantify the role of plasticity in N uptake and plant yield. Based on a greenhouse experiment we considered plasticity in two maize (Zea mays) traits: root-to-leaf biomass allocation ratio and emergence rate of axial roots. In a simulation experiment we individually enabled or disabled both plastic responses for maize stands grown across six N levels. Both plastic responses contributed to maintaining a higher N uptake, and plant productivity as N availability declined compared with stands in which plastic responses were disabled. We conclude that plastic responses quantified in this study may be a potential target trait in breeding programs for greater N uptake across N levels while it may only be important for the internal use of N under N-limited conditions in maize. Given the complexity of breeding for plastic responses, an a priori model analysis is useful to identify which plastic traits to target for enhanced plant performance.
Subinhibitory concentrations of nisin enhance virulence gene expression in Staphylococcus aureus and increase mortality in Galleria mellonella
Authors: Rodrigues Ramila Cristiane , Andre Cleriane , Dantas Vanetti Maria Cristina 
Published: July 2024

Abstract
Alternative strategies for controlling Staphylococcus aureus and other pathogens have been continuously investigated, with nisin, a bacteriocin widely used in the food industry as a biopreservative, gaining increasing attention. In addition to its antimicrobial properties, bacteriocins have significant effects on genome functionality even at inhibitory concentrations. This study investigated the impact of subinhibitory concentrations of nisin on S. aureus. Culturing in the presence of 0.625 μmol l−1 nisin, led to the increased relative expression of hla, saeR, and sarA, genes associated with virulence while expression of the sea gene, encoding staphylococcal enterotoxin A (SEA), decreased. In an in vivo experiment, Galleria mellonella larvae inoculated with S. aureus cultured in the presence of nisin exhibited 97% mortality at 72 h post-infection, compared to over 40% of larvae mortality in larvae infected with S. aureus. A comprehensive understanding of the effect of nisin on the transcriptional response of virulence genes and the impact of these changes on the virulence of S. aureus can contribute to assessing the application of this bacteriocin in food and medical contexts.
High-Quality Hospital Status on Health Care Costs for Pediatric Congenital Heart Disease Care for U.S. Military Beneficiaries
Authors: El-Amin Amber , Koehlmoos Tracey , Yue Dahai , Chen Jie , Cho Nam Yong , Benharash Peyman , Franzini Luisa 
Published: July 2024

ABSTRACT

Introduction
Congenital heart disease (CHD) is the most common and resource demanding birth defect managed in the United States, with approximately 40,000 children undergoing CHD surgery year. Researchers have compared high-volume to low-volume hospitals and found significant hospital-level variation in major complications, health resource utilization, and health care costs after CHD surgery.

Materials and Methods
Using nationwide representative claim data from the United States Military Health System from 2016 to 2020, TRICARE beneficiaries diagnosed with CHD were tabulated based on ICD-10 codes (International Classification of Diseases, 10th revision). We examined the relationships between total costs and total hospitalizations costs post 1-year CHD diagnosis and presence or absence of High-Quality Hospital (HQH) designation. We applied both the naive generalized linear model (GLM) to control for the observed patient and hospital characteristics and the 2-stage least squares (2SLS) model to account for the unobserved confounding factors. This study was approved by University of Maryland, College Park Institutional Review Board (IRB) (Approval Number: 1576246-2).

Results
A relationship between HQH designation and total CHD related costs was not seen across 2SLS model specifications (marginal effect; −$41,579; 95% CI, −$83,429 to $271). For patients diagnosed with a moderate-complex or single ventricle CHD, the association of HQH status was a statistically significant reduction in total costs (marginal effect; −$84,395; 95% CI, −$140,560 to −$28,229) and hospitalization costs (marginal effect; −$73,958; 95% CI, −$121,878 to −$26,039).

Conclusions
It is very imperative for clinicians and patient support advocates to urge policymakers to deliberate the establishment of a quality designation authority for CHD management. These efforts will not only help to identify and standardize quality care metrics but to improve long-term health, effectiveness, and equity in the management of CHD. Furthermore, these efforts can be used to navigate patients to proven HQH, thereby improving care and reducing associated treatment costs for CHD patients.
Commentary—A Military Health Care Ethics Framework
Authors: Beardmore Charlie , Bricknell Martin C M , Kelly Janet , Lough Fred 
Published: July 2024

ABSTRACT
Ethical practice within military health care is a significant topic of professional and academic debate. The term “military health care ethics” enfranchises the entire health care team. Military health care professionals are subject to tension between their duties as military personnel, and their ethical duties as health care professionals, so-called “Dual Loyalty.” Some military health care practitioners have suffered moral injury because of the psychological stress associated with ethical challenges on military operations. It is important to define military health care ethics and also to consider how it should be taught. The essence of ethical practice is ethical decision-making. It has become self-evident from our experience of teaching military health care ethics that a simple and agreed framework for analyzing an ethical problem is required. This paper describes the development of the King’s Military Healthcare Ethics Framework in support of a military health care ethics policy on behalf of the NATO Military Healthcare Working Group. There is logic to using a stepped approach to analyze an ethical problem in military health care. These steps are: “Identify” the problem, “Analyze” the problem including consideration of perspectives, “Fuse” the analysis, and “Decide”. Step 1—Identify—is intended to orientate the decision-making group, and to articulate the problem specifically and clearly in order to determine the exact ethical issue and the secondary issues that arise. Step 2—Analyse—considers the problem from 4 perspectives: patient, clinical, legal, and societal/military. These reflect the breadth of perspectives that impact on health care practice within a military context. Step 3—Fuse—is the culminating step. The conclusions from the analysis of perspectives should be summarized and key references cited. This will determine the exact decision(s) to be made. Step 4—Decide—clearly articulates the decision made and provides the record of the key reasons for making that decision. This may include areas of enduring uncertainly and any planned review of the decision. The King’s Military Healthcare Ethics Analytical Framework has been evaluated for content validity through iterative discussion at 4 meetings of the NATO MHCWG and a specific workshop on military health care ethics over 2022/2023. It is included within the draft NATO Standardization Agreement on Military Healthcare Ethics.
Two dynamically discovered compact object candidate binary systems from LAMOST low-resolution survey
Authors: Qi Senyu , Gu Wei-Min , Zhang Zhi-Xiang , Yi Tuan , Liu Jin-Zhong , Zheng Ling-Lin 
Published: July 2024

ABSTRACT
We report two binary systems, LAMOST J035540 + 381550 (hereafter J035540) and LAMOST J035916 + 400732 (hereafter J035916), identified through the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) low-resolution survey (LRS). Each of these two systems contains an M-type star orbiting with a invisible compact object candidate. Follow-up spectroscopic observations of Palomar 200-in. telescope (P200) enhance radial velocity measurements. We use radial velocities from LAMOST and P200, as well as light curves from Zwicky Transient Facility (ZTF) to constrain orbital parameters. The masses of the visible M-type stars are estimated by fitting the MIST isochrones and spectral energy distributions. The mass functions for the unseen companions are: $0.22\pm 0.01\,{\rm M}_{\odot }$ for J035540 and $0.16\pm 0.01\, {\rm M}_{\odot }$ for J035916. With the orbital and stellar parameters derived above and assuming the orbital inclination is 90° (edge-on), we find that the minimum masses of the invisible companions exceeds that of the visible stars. The single-lined feature and the dynamical evidence suggest the presence of compact objects. J035540’s ZTF light curve, modelled with phoebe, yields a compact object mass of $0.70^{+0.12}_{-0.05}\, {\rm M}_{\odot }$. For J035916, ellipsoidal modulation analysis constrains the light-curve amplitude, yielding a compact object mass range of $0.57-0.90\, {\rm M}_{\odot }$. The mass estimates indicate that both are likely white dwarfs. These findings underscore the efficiency of optical time-domain surveys and dynamical methods in identifying faint, massive white dwarfs, along with other compact objects in binaries.