bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychiatric Hospitals and the Ethics of Salutogenic Design: The Return of Moral Architecture?
Authors: Crnic Meghan , Bi Stephanie , Candilis Philip J. , Sisti Dominic 
Published: July 2024

Abstract
Bioethicists have long been concerned with the mistreatment of institutionalized patients, including those suffering from mental illness. Despite this attention, the built environments of health care settings have largely escaped bioethical analysis. This is a striking oversight given that architects and social scientists agree that buildings reflect and reinforce prevailing social, cultural, and medical attitudes. Architectural choices are therefore ethical choices. We argue that mental health institutions are fertile sites for ethical analysis. Examining the ethics of architecture calls attention to the potential for hospitals to hinder autonomy. Additionally, such examination highlights the salutogenic possibilities of institutional design, that is to care, nurture, and enhance patient and provider well-being.
Do sex and handedness influence general cognition and financial capacity in patients with aMCI and healthy older adults? Emphasis on women's performance
Authors: Giannouli Vaitsa , Milienos Fotios S. 
Published: July 2024

Abstract

Objectives:
The effects of sex and handedness on financial capacity performance remain unexplored both in healthy older adults and in patients with amnestic mild cognitive impairment (aMCI).

Methods:
The aim of this study was to study the effect of the above factors (sex, handedness, and health condition), following a factorial experimental design; hence, eight groups (each with ten individuals) with similar demographic characteristics (age and education level) were formed consisting of right/left-handed, women/men and healthy/not healthy (with a diagnosis of aMCI) older adults. Mini-Mental State Examination (MMSE) was administered as a measure of general cognitive ability, and Legal Capacity for Property Law Transactions Assessment Scale (LCPLTAS) was used as an indicator of financial capacity; moreover, GDS-15 was used to assess depressive symptomatology. Self-reports of hand preference were also included.

Results:
Although as expected healthy men and women regardless of their handedness outperformed aMCI patients on MMSE and LCPLTAS, performance on cash transactions, bank statement management, bill payment, financial decision making, and knowledge of personal assets from LCPLTAS is significantly higher for right-handed aMCI women compared with left-handed aMCI women.

Conclusions:
Future research should further elucidate the reasons for this left-handed female patient with aMCI profile in larger groups of patients. This is an exploratory study, and the small sample size limits the strength of conclusions; further studies on this topic are needed.
Impact of 30% supramolecular salicylic acid combined with ultra-pulse carbon dioxide fractional laser therapy on facial atrophic acne scars
Authors: Liu Xiu-Feng , Yu Man-Chang 
Published: July 2024

Objective:
To assess the impact of 30% supramolecular salicylic acid (SSA) combined with ultra-pulse carbon dioxide (CO2) fractional laser therapy on facial atrophic acne scars.

Methods:
This retrospective study included patients with atrophic acne scars treated from June 2020 to June 2022. The patients were divided into the combination group (SSA combined with ultra-pulse CO2 fractional laser therapy) and the laser group (ultra-pulse CO2 fractional laser therapy alone). Four treatment sessions were conducted for each group. Follow-up visits were performed every 2 months after each treatment and included assessments of the Échelle d'Évaluation clinique des cicatrices d'acné (ECCA) score, effective rate, and visual analogue scale score.

Results:
The combination and laser groups comprised 72 and 61 patients, respectively. There were no significant differences in sex, age, or baseline ECCA score between the two groups. The effective rate (95.8% vs. 67.2%, P < 0.001) was higher and the pain scores (during and after the intervention) were lower in the combination group than in the laser group (P < 0.001). The severity of erythema, edema, and crusting was milder in the combination group (P < 0.001). The proportion of highly satisfied patients was higher (73.6% vs. 31.2%, P < 0.001) and the Dermatology Life Quality Index showed greater improvement (0.15 ± 0.40 vs. 1.39 ± 1.53, P < 0.001) in the combination group than in the laser group.

Conclusion:
The combination of ultra-pulse CO2 fractional laser therapy and 30% supramolecular SSA had improved efficacy in treating facial atrophic acne scars without increasing pain or inducing adverse reactions.
Core decompression combined with bone marrow mononuclear cells in the treatment of femoral head necrosis: a systematic review and meta-analysis
Authors: Zhu Ying , Tang Peiyuan , Chai Hua , Ma Wenbo , Cao Yangbin , Tan Han , Lin Bin , Xiao Wenfeng , Wen Ting , Li Yusheng 
Published: July 2024

Background:
The effectiveness of bone marrow mononuclear cells (BMMCs) combined with core decompression (CD) in the treatment of femoral head necrosis is controversial. The purpose of this study was to conduct a meta-analysis and systematic review of the evaluation of BMMCss combined with CD in the treatment of femoral head necrosis and to compare the therapeutic effect of this method with that of CD alone so as to provide a basis for subsequent research and clinical treatment.

Methods:
We conducted detailed searches across four databases in Embase, PubMed, Web of Science, and the Cochrane Library (up to October 2023), including eight studies with a total of 370 participants and 491 hip cases. This meta-analysis followed the Preferred Reporting Project (PRISMA) guidelines. Review Manager 5.4 was used to summarize and analyze the outcome indicators and the quality and reliability of the MAs were graded against a Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2).

Results:
Eight studies were included in the inclusion criteria. The results of meta-analysis showed that the therapeutic effect of CD combined with BMMC on visual analog scale was better than that of CD alone [mean difference (MD)=−5.32, 95% confidence interval (CI): −9.90, −0.74, P=0.02, I
2=98%], and there was no statistically significant difference between CD combined with BMMC and CD alone in the treatment of Harris hip score (MD=2.73, 95% CI: −2.63, 8.09, P=0.32, I
2=82%). We conducted a sensitivity analysis. The results showed that the CD joint BMMC treatment effect on the Harris hip score is superior to the single CD (MD=5.57, 95% CI: 1.94, 9.20, P=0.003, I
2=0%), both no significant differences in visual analog scale (MD=0.47, 95% CI: −1.74, 0.79, P=0.46, I
2=83%).

Conclusion:
In this study, we found that CD combined with bone marrow monocyte therapy improved femoral head necrosis better than CD alone.
A bibliometric and visualization analysis of global research status and frontiers on autophagy in cardiomyopathies from 2004 to 2023
Authors: Zeng Xianghui , Shu Bin , Zeng Qingfeng , Wang Xianggui , Li Kening , Wu Jincheng , Luo Jianping 
Published: July 2024

Background:
Autophagy is intimately associated with the development of cardiomyopathy and has received widespread attention in recent years. However, no relevant bibliometric analysis is reported at present. In order to summarize the research status of autophagy in cardiomyopathy and provide direction for future research, we conducted a comprehensive, detailed, and multidimensional bibliometric analysis of the literature published in this field from 2004 to 2023.

Methods:
All literatures related to autophagy in cardiomyopathy from 2004 to 2023 was collected from the Web of Science Core Collection, and annual papers, global publication trends, and proportion charts were analyzed and plotted using GraphPad price v8.0.2. In addition, CtieSpace [6.2.4R (64-bit) Advanced Edition] and VOSviewer (1.6.18 Edition) were used to analyze and visualize these data.

Results:
Two thousand two hundred seventy-nine papers about autophagy in cardiomyopathy were accessed in the Web of Science Core Collection over the last 20 years, comprising literatures from 70 countries and regions, 2208 institutions, and 10 810 authors. China contributes 56.32% of the total publications, substantially surpassing other countries, while the United States is ranked first in frequency of citations. Among the top 10 authors, six are from China, and four are from the United States. Air Force Military Medical University was the institution with the highest number of publications, while the Journal of Molecular and Cellular Cardiology (62 articles, 2.71% of the total) was the journal with the highest number of papers published in the field. Clustering of co-cited references and temporal clustering analysis showed that ferroptosis, hydrogen sulfide mitophagy, lipid peroxidation, oxidative stress, and SIRT1 are hot topics and trends in the field. The principal keywords are oxidative stress, heart, and heart failure.

Conclusion:
The research on autophagy in cardiomyopathy is in the developmental stage. This represents the first bibliometric analysis of autophagy in cardiomyopathy, revealing the current research hotspots and future research directions in this field.
Routine end-ischemic hypothermic machine perfusion in liver transplantation from donors after brain death: results of 2-year follow-up of a randomized controlled trial
Authors: Morawski Marcin , Zhylko Andriy , Rykowski Paweł , Krasnodębski Maciej , Hołówko Wacław , Lewandowski Zbigniew , Mielczarek-Puta Magdalena , Struga Marta , Szczepankiewicz Benedykt , Górnicka Barbara , Krawczyk Marek , Grąt Michał 
Published: July 2024

Background:
Data on routine hypothermic machine perfusion of livers procured from donors after brain death (DBD) are scarce, and the benefits of the method have only been demonstrated in extended criteria grafts. This study aimed to assess if end-ischemic dual hypothermic oxygenated machine perfusion (dHOPE) is superior to static cold storage (SCS) in preservation of livers procured from DBD donors with respect to long-term outcomes. Existing data on short-term outcomes favours dHOPE in patients receiving high-risk grafts.

Methods:
This prospective randomized controlled trial included 104 recipients of DBD livers randomly assigned to SCS arm (78 patients) and the dHOPE arm (26 patients). Endpoints of interest were the occurrence of biliary complications (biliary fistula, anastomotic, and nonanastomotic strictures) and overall patient and graft survival (GS) during the 2-year follow-up.

Results:
A total of 36 patients developed biliary complications (at least one event) – six events in dHOPE arm and 30 in SCS arm. There was no significant difference in biliary complications between groups (23.7 vs. 43.4%, P=0.11). No differences were found significant with respect to anastomotic (19.9 vs. 33.7%, P=0.20) and nonanastomotic strictures (0 vs. 11.1%, P=0.10) as well as biliary fistulas (11.7 vs. 12.2%, P=0.93). Survival analysis did not show significantly different results in the study population – overall survival: 92.3% in dHOPE and 83.9% in SCS (P=0.35), and GS: 92.3 and 81.4% (P=0.23), respectively. However, a significant difference in GS was noted in recipients of high-risk grafts – 100% in dHOPE and 73.1% in SCS, respectively (P=0.038).

Conclusions:
The long-term outcome data suggest that the routine use of dHOPE may be beneficial for recipients of high-risk grafts from DBD donors. The present study does not provide any evidence for the benefits of dHOPE in low-risk grafts.
Aryl hydrocarbon receptor repressor (AHRR) methylation predicts risk of vascular disease: A cohort study of the general population
Authors: Skov-Jeppesen Sune M. , Kobylecki Camilla J. , Jacobsen Katja K. , Bojesen Stig E. 
Published: July 2024

Aims:
Smoking is a risk factor for cardiovascular disease, but there is currently no clinically established biomarker for its cardiovascular damage. We aimed to investigate the hypothesis that aryl hydrocarbon receptor repressor (AHRR) methylation at CpG site cg05575921, a biomarker of smoking behavior, is associated with the risk of peripheral artery disease (PAD) and aortic aneurysm (AA) in the general population.

Methods and results:
In this prospective cohort study of the general population, we measured AHRR methylation in individuals from three visits to the Copenhagen City Heart Study. Information on risk factors was collected at visits with 10 years intervals; visit 1 (1991–1994), visit 2 (2001–2003), and visit 3 (2011–2015). Individuals were followed up in the Danish National Patient Register for PAD and AA until December 2018. Subhazard ratios were calculated using Fine and Gray competing risk regression. In 11 332 individuals from visit 1 (n=9234), visit 2 (n=5384), and visit 3 (n=4387), there were 613 and 219 events of PAD and AA during up to 26.5 years of follow-up. AHRR hypomethylation was associated with a higher risk of PAD and AA with multivariable-adjusted subhazard ratios of 2.82 (1.91; 4.15) for PAD and 2.88 (1.42; 5.88) for AA in individuals within the lowest versus highest methylation quintile.

Conclusions:
We found that AHRR methylation, a strong biomarker for smoking, was associated with the risk of PAD and AA. AHRR methylation could be a useful tool in more personalized risk prediction of PAD and AA.
Just-in-Time Video Using QR Codes: An Approach to Pediatric Trauma Nursing Education
Authors: Mudry Nicholas Fraser , Roney Linda Nancy 
Published: July 2024

BACKGROUND:
High acuity trauma and patients in cardiopulmonary arrest are not frequently seen in all pediatric Level I trauma centers. Yet, nurses are required to manage these patients in fast-paced, high-pressure environments.

OBJECTIVE:
This project aims to develop and evaluate an education program for high-risk, low-volume equipment and skills in the pediatric emergency department setting.

METHODS:
This is a pre- and post-quality improvement study conducted in a Northeastern United States pediatric Level I trauma center. Emergency department nurses were invited to view videos detailing high-risk, low-volume equipment use. For the convenience of access, Quick Response (QR) codes linked to the videos were placed on each piece of equipment reviewed. General self-efficacy and levels of self-efficacy in using the equipment were assessed before the intervention and again after 4 weeks from January to February 2023.

RESULTS:
A total of 43 pediatric emergency nurses participated in the education. The mean aggregate general self-efficacy score was 32.93. Mean scores in all areas (Level 1 rapid infuser, fluid warmer, blood administration, and securing an endotracheal tube) improved after the intervention.

CONCLUSIONS:
Easily accessible, brief refresher videos linked to QR codes in the pediatric emergency department can help empower nurses who need to use high-risk, low-volume equipment.
Trends in Sexual Orientation and Gender Identity Data Collection
Authors: Boehmer Ulrike , LeClair Amy M. , Jesdale Bill M. 
Published: July 2024

Objective:
The aim of this study was to determine response patterns to sexual orientation and gender identity (SOGI) questions in the Behavioral Risk Factor Surveillance System (BRFSS) over time and to assess nonresponse and indeterminate responses by demographic characteristics.

Methods:
This is a secondary data analysis of the SOGI module of the BRFSS. We used data from 46 states and Guam that implemented SOGI questions between 2014 and 2022. We used weighted analyses that accounted for the sampling design, determined SOGI response patterns by year, and assessed nonresponse and indeterminate responses by demographic characteristics.

Results:
Over time, increasing numbers self-reported as sexual and gender minority respondents, while heterosexual identity declined. Sexual orientation nonresponse and indeterminate responses increased with time, while respondents’ reports of not knowing gender identity declined. Hispanic, older, respondents, those with lower education, and those who completed the questionnaire in Spanish had higher SOGI nonresponse and indeterminate responses.

Conclusions:
The low amount of SOGI nonresponse and indeterminate responses in the BRFSS can be instructive for the implementation of SOGI questions in medical settings. SOGI data collection in all settings requires improving procedures for the groups that have been shown to have elevated nonresponse and indeterminate response.
Burden of aortic aneurysm in Iran from 1990 to 2019: an analysis based on global burden of disease study
Authors: Mellat-Ardakani Milad , Atighi Kaveh , Rahmani Shahryar , Simiyari Saba , Salahshour Faeze 
Published: July 2024

Background:
Limited studies have been conducted on the epidemiology of aortic aneurysms in Iran. In this study, the authors aimed to comprehensively evaluate the burden and epidemiology of aortic aneurysms across various age groups, sexes, and provinces in Iran from 1990 to 2019.

Materials and methods:
The authors used global burden of disease (GBD) study data in the current study. The authors retrieved data on the burden of aortic aneurysms across sexes and age groups at national and subnational levels from 1990 to 2019. The authors extracted mortality, years of life lost (YLL), years lived with disability (YLD), and disability-adjusted life year (DALY), numbers, rates, and age-standardized rates. Additionally, the authors extracted the burden of AA attributable to its risk factors, such as lead exposure, high systolic blood pressure, high dietary intake of sodium, and smoking.

Results:
National ASDR (age-standardized DALY rate) was also observed to be reduced from 1990 [22.20 (17.46–26.86)] to 2019 [19.97 (17.98–21.98)]. However, the inclinations were evaluated to be slighter than the world (%change ASDR=−19.5%). In 2019, three leading risk factors yielding death in AA patients were smoking [ASMR attributable=0.73 (0.67–0.80)], high sodium intake [ASMR attributable=0.11 (0.03–0.27)], and lead exposure [ASMR attributable=0.04 (0.02–0.07)].

Conclusion:
Mortality and DALYs due to AA both decreased slightly during the last three decades. Considering the role of smoking in the burden of AA in Iran, interventions targeting smoking cessation among high-risk groups, such as males, may be helpful to reduce the burden of AA in Iran in the coming years.
Effect of early versus late onset of partial visual loss on judgments of auditory distance
Authors: Pardhan Shahina , Raman Rajiv , Moore Brian C. J. , Cirstea Silvia , Velu Saranya , Kolarik Andrew J. 
Published: July 2024

SIGNIFICANCE
It is important to know whether early-onset vision loss and late-onset vision loss are associated with differences in the estimation of distances of sound sources within the environment. People with vision loss rely heavily on auditory cues for path planning, safe navigation, avoiding collisions, and activities of daily living.

PURPOSE
Loss of vision can lead to substantial changes in auditory abilities. It is unclear whether differences in sound distance estimation exist in people with early-onset partial vision loss, late-onset partial vision loss, and normal vision. We investigated distance estimates for a range of sound sources and auditory environments in groups of participants with early- or late-onset partial visual loss and sighted controls.

METHODS
Fifty-two participants heard static sounds with virtual distances ranging from 1.2 to 13.8 m within a simulated room. The room simulated either anechoic (no echoes) or reverberant environments. Stimuli were speech, music, or noise. Single sounds were presented, and participants reported the estimated distance of the sound source. Each participant took part in 480 trials.

RESULTS
Analysis of variance showed significant main effects of visual status (p<0.05) environment (reverberant vs. anechoic, p<0.05) and also of the stimulus (p<0.05). Significant differences (p<0.05) were shown in the estimation of distances of sound sources between early-onset visually impaired participants and sighted controls for closer distances for all conditions except the anechoic speech condition and at middle distances for all conditions except the reverberant speech and music conditions. Late-onset visually impaired participants and sighted controls showed similar performance (p>0.05).

CONCLUSIONS
The findings suggest that early-onset partial vision loss results in significant changes in judged auditory distance in different environments, especially for close and middle distances. Late-onset partial visual loss has less of an impact on the ability to estimate the distance of sound sources. The findings are consistent with a theoretical framework, the perceptual restructuring hypothesis, which was recently proposed to account for the effects of vision loss on audition.
Achieving Clinical Success in Nonsedated Velopharyngeal Magnetic Resonance Imaging: Optimizing Data Quality and Patient Selection
Authors: Mason Kazlin N. , Gampper Thomas , Black Jonathan 
Published: July 2024

Background:
The ability of magnetic resonance imaging (MRI) to visualize the velopharyngeal (VP) musculature in vivo makes it the only imaging modality available for this purpose. This underscores a need for exploration into clinical translation of this imaging modality for craniofacial teams. The purpose of this study was to assess outcomes of a clinically feasible VP MRI protocol and describe the ideal patient population for use of this imaging protocol.

Methods:
Sixty children (2 to 12 years of age) with VP insufficiency underwent a nonsedated, child-friendly MRI protocol. No exclusions based on syndromic conditions were made. Logistic regression assessed predictors of VP MRI success and multinomial logistic regression evaluated factors influencing quality of anatomic data.

Results:
An 85% overall success rate was achieved, including children as young as 2 years and those with syndromic diagnoses. Stratifying by age revealed a 97.5% success rate in children ages 4 and up. The regression model (χ2[5] = 37.443; P < 0.001) explained 81.4% of success rate variance, correctly classifying 93.3% of cases. Increased age significantly predicted success (P = 0.046); sex and syndromic conditions did not. Multinomial regression identified preparatory materials (P = 0.011) and audio/video during the scan (P = 0.024) as predictors for improved image quality.

Conclusions:
Implementation of VP MRI is feasible for a broad population of children with VP insufficiency, including those with concomitant syndromic diagnoses. Quality is improved by incorporating prescan preparation and audiovisual stimuli during scans. This underscores the potential of VP MRI as a valuable tool in clinical settings, especially for presurgical assessments.
Modified Dautrey’s Procedure for Recurrent Temporomandibular Joint Dislocation
Authors: An Wei , Chen Jiayi , An Jingang 
Published: July 2024

This study introduced and analyzed the clinical effects of a modified Dautrey’s procedure, involving down-fracture of the zygomatic arch and articular tubercle augmentation, for the treatment of recurrent TMJ dislocation. Recurrent TMJ dislocation patients were treated using the modified Dautrey’s procedure. The recurrence of joint dislocation, maximal mouth opening (MMO), and pain were evaluated postoperatively. A total of 7 patients were treated using the modified procedure, with no instances of facial nerve injury. No recurrences occurred during the follow-up period of 0.5 to 5 years. The average MMO was 35.4 mm and 35.7 mm before the operation and during follow-up, respectively. The modified Dautrey’s procedure was effective and particularly suitable for elderly patients with abnormal muscle control, resulting in low recurrence.