bluuebunny/crossref_metadata_2025_split huggingface dataset:
A broad genome survey reveals widespread presence of secretoglobin genes in squamate and archosaur reptiles that flowered into diversity in mammals
Authors: Karn Robert C , Laukaitis Christina M 
Published: February 2025

Abstract
Secretoglobins (SCGBs) are a superfamily of small, dimeric, cytokine-like proteins found originally in the reproductive tracts and airways of mammals. Most SCGB research has focused on respiratory diseases in humans and laboratory animal models but knowledge of their biological functions is sparse. We report here a broad survey of Scgbs, the genes that encode SCGBs, in animal genomes. We tested the view that they are uniquely mammalian in origin and distribution, hoping that understanding their distribution would shed light on their evolutionary history and perhaps point to putative biological functions. Rather than being uniquely mammalian, we found many different SCGBs in turtles, crocodilians, lizards and birds, suggesting they existed in the Carboniferous period (approximately 320 MYA) when the sauropsids evolved in the amniote lineage. We identified no SCGBs in amphibians or fishes, suggesting that this characteristic originated in an amniote ancestor. Amniotes include sauropsid and synapsid lineages and three subfamilies of SCGBs (SCGB2A, SCGB3A, and SCGB1C) are found in both sauropsid and synapsid lineages. Uteroglobin (SCGB1A), the first identified SCGB protein, is uniquely mammalian, having appeared in monotremes. The SCGB subfamilies including Androgen-binding proteins (ABPs; SCGB1B, SCGB2B) are first seen in metatherians. This complex distribution suggests that there is an as-yet-undiscovered basic function of secretoglobins shared by all amniotes.
Social Pathologies and the Fear of Ageing in Houellebecq’s Postmodern Narrative
Authors: Stončikaitė Ieva 
Published: February 2025

Abstract
In Michel Houellebecq’s écriture grise, the decline of Western civilisation is intertwined with contemporary maladies and the fear of ageing. A bleak depiction of ageing bodies functions as an extended metaphor for broader social pathologies, including the decline of spirituality, community well-being, and traditional values. Recurring themes such as the obsession with sex and anti-ageing bodywork, the cult of youth, compulsive consumerism, and erotic hedonism reflect Houellebecq’s critique of the transformations of the second half of the 20th century. Many of his protagonists, trapped in an existential midlife crisis and driven by anxieties related to intimate relationships and societal pressures to remain functional, youthful, and engaged, frequently resort to suicide. Using the framework of interdisciplinary age studies and the critical theory of social pathologies, this article discusses how Houellebecq’s characters struggle to navigate the challenges within competitive neoliberal imperatives, libidinal economies, and the discourse of successful ageing. It also underscores how his oeuvre, often characterised as apocalyptic, dystopian, or neo-decadent, advocates for authentic connection, care, faith, and unconditional love as essential components of human existence and survival.
‘Immigrant gifts’: Alphonso Trumpbour Clearwater, colonial silver and the limits of ‘Americanization’, 1906–1933
Authors: Conlin Jonathan 
Published: February 2025

Abstract
The Clearwater Bequest of 1933 is a landmark in the development of the Metropolitan Museum of Art’s holdings of American silver, and in the American Colonial Revival more broadly. Alphonso Trumpbour Clearwater (1848–1933) was a judge, antiquary and pillar of society in Kingston, New York. Drawing on the Clearwater papers at the Winterthur Museum in Delaware, as well as his correspondence with curators at the Metropolitan Museum of Art and other museums, this essay considers the origin in late nineteenth-century fairs of Clearwater’s collecting of late seventeenth- and eighteenth-century silver; his evolving taste and relations with dealers, curators and rival collectors in the decades before and after the opening of the Metropolitan’s American Wing (1924); and the interaction of his views on what kind of silver ‘belonged’ in his collection with his views on what kind of people did and did not ‘belong’ in the United States.
A Gaussian sliding windows regression model for hydrological inference
Authors: Schrunner Stefan , Pishrobat Parham , Janssen Joseph , Jenul Anna , Cao Jiguo , Ameli Ali A , Welch William J 
Published: February 2025

Abstract
Statistical models are an essential tool to model, forecast, and understand the hydrological processes in watersheds. In particular, the understanding of time lags associated with the delay between rainfall occurrence and subsequent changes in streamflow is of high practical importance. Since water can take a variety of flow paths to generate streamflow, a series of distinct runoff pulses may combine to create the observed streamflow time series. Current state-of-the-art models are not able to sufficiently confront the problem complexity with interpretable parametrization, thus preventing novel insights about the dynamics of distinct flow paths from being formed. The proposed Gaussian Sliding Windows Regression Model targets this problem by combining the concept of multiple windows sliding along the time axis with multiple linear regression. The window kernels, which indicate the weights applied to different time lags, are implemented via Gaussian-shaped kernels. As a result, straightforward process inference can be achieved since each window can represent one flow path. Experiments on simulated and real-world scenarios underline that the proposed model achieves accurate parameter estimates and competitive predictive performance, while fostering explainable and interpretable hydrological modelling.
Expedited Chemoradiation after Laser Interstitial Thermal Therapy (LITT) is Feasible and Safe in Patients with Newly Diagnosed Glioblastoma
Authors: Yu Jennifer S , Meade Seth M , Zhao Ran , Wei Wei , Dashora Himanshu , Prayson Richard , Grabowski Matthew M , Stevens Glen , Lobbous Mina , Murphy Erin S , Suh John H , Chao Samuel T , Barnett Gene H , Peereboom David , Ahluwalia Manmeet S , Mohammadi Alireza M 
Published: February 2025

Abstract

Background
High-grade gliomas (HGG) are incurable primary brain tumors. Laser Interstitial Thermal Therapy (LITT) has emerged as an alternative to surgery for select patients. Hyperthermia can improve the efficacy of radiation and chemotherapy. Shortening the time between LITT and chemoradiation may maximize their biological and clinical benefits. This trial evaluated the safety and feasibility of expediting chemoradiation after biopsy and LITT in patients with newly-diagnosed HGG.

Methods
Patients with suspected HGG were enrolled. Those with pathologic confirmation of HGG and deemed appropriate candidates for LITT and chemoradiation were considered evaluable. Participants underwent 6 weeks of adjuvant chemoradiation initiated within seven days of LITT. Endpoints were assessed until the completion of radiation, and included the occurrence of wound dehiscence; new, treatment-refractory seizures; cerebral edema; and completion of planned radiotherapy.

Results
Thirteen patients with suspected HGG were enrolled and ten were considered evaluable. All ten patients were diagnosed with glioblastoma (GBM, IDHwt). Three patients were deemed unevaluable: two patients with other CNS tumors and one GBM patient who developed grade 4 postoperative edema. Of ten evaluable patients, the median age was 60.2 years (IQR: 51.0, 69.4), and median preoperative KPS was 90 (IQR: 90, 80). The median time between LITT and the initiation of chemoradiation was seven days. There were no occurrences of significant protocol-related adverse events.

Conclusions
Accelerated initiation of chemoradiation after biopsy and LITT is safe and feasible for patients with newly diagnosed GBM. A larger study is needed to assess potential synergy of hyperthermia and chemoradiation to improve survival.
Histopathologically Confirmed Radiation Necrosis: Risk Factors and Clinical Outcomes in Patients with Primary Brain Tumors
Authors: Hazaymeh Mohammad , Malinova Vesna , Stork Lidia , Metz Imke , Stadelmann Christine , Huckhagel Torge , Dröge Leif Hendrik , El Shafie Rami , Mielke Dorothee , Rohde Veit , Abboud Tammam 
Published: February 2025

Abstract

Background
Radiation necrosis is a recognized complication following radiotherapy for primary brain tumors, presenting diagnostic and therapeutic challenges, and potentially masquerading as tumor recurrence. This study aims to delineate the clinical trajectory, management strategies, and outcomes of histologically confirmed radiation necrosis in patients treated for primary brain tumors.

Methods
We conducted a retrospective review of patients who underwent surgical intervention for suspected tumor recurrence at our institution between 2010 and 2022, following adjuvant radiotherapy. Cases with histopathologically confirmed radiation necrosis were identified and analyzed for onset, clinical symptoms, radiological features, correlation with radio- and chemotherapy, management approaches, and disease progression.

Results
Out of 276 patients operated for suspected recurrent brain tumors, 14 (5%) were histopathologically diagnosed with radiation necrosis. The latency period from radiotherapy to diagnosis ranged from 3 to 40 months. Notably, patients with oligodendrogliomas exhibited a significantly higher incidence of radiation necrosis (26%), underscoring a substantial risk association (P &lt; 0.001). Conversely, the rates of radiation necrosis in patients with glioblastoma and astrocytoma (WHO grade II and III) were lower, at 2% and 0%, respectively, suggesting a lower risk association (P &lt; 0.001 and P = 0.036, respectively). The majority (79%) of these patients were asymptomatic and exhibited a favorable clinical course, with most cases showing no progression of necrosis. During the follow-up period, tumor recurrence was verified in 2 patients.

Conclusion
Radiation necrosis post-radiotherapy for primary brain tumors occurs infrequently but predominantly in patients with oligodendrogliomas, often following a benign course. The study underscores the importance of close monitoring for this condition, given the potential for sampling errors and the critical need for histopathological confirmation to guide appropriate management.
Social inequality and cultural factors impact the awareness and reaction during the cryptic transmission period of pandemic
Authors: Jiang Zhuoren , Liu Xiaozhong , Kang Yangyang , Sun Changlong , Ahn Yong-Yeol , Bollen Johan 
Published: February 2025

Abstract
The World Health Organization (WHO) declared the COVID-19 outbreak a Public Health Emergency of International Concern on 2020 January 31. However, rumors of a “mysterious virus” had already been circulating in China in 2019 December, possibly preceding the first confirmed COVID-19 case. Understanding how awareness about an emerging pandemic spreads through society is vital not only for enhancing disease surveillance, but also for mitigating demand shocks and social inequities, such as shortages of personal protective equipment and essential supplies. Here we leverage a massive e-commerce dataset comprising 150 billion online queries and purchase records from 94 million people to detect the traces of early awareness and public response during the cryptic transmission period of COVID-19. Our analysis focuses on identifying information gaps across different demographic cohorts, revealing significant social inequities and the role of cultural factors in shaping awareness diffusion and response behaviors. By modeling awareness diffusion in heterogeneous social networks and analyzing online shopping behavior, we uncover the evolving characteristics of vulnerable populations. Our findings expand the theoretical understanding of awareness spread and social inequality in the early stages of a pandemic, highlighting the critical importance of e-commerce data and social network data in effectively and timely addressing future pandemic challenges. We also provide actionable recommendations to better manage and mitigate dynamic social inequalities in public health crises.
The Impact of Experiences with COVID-19 on the 2020 Presidential Election and Support for Health Reform
Authors: Kavanagh Nolan M , Menon Anil 
Published: February 2025

Abstract
Health shocks may drive the public to support policies and candidates that protect health and well-being. Did the COVID-19 pandemic, as one such shock, shift preferences for health reform in the United States? Using nationally representative surveys of over 70,000 US adults between 2019 and 2020, we find that experiences with COVID-19—measured at both the individual and community levels—increased support for Medicare for All by multiple percentage points. Consistent with partisan entrenchment on health issues, independents and weak partisans drove the association at the individual level; these subgroup differences were not observed for community-level experiences. To reduce concerns about confounding, we use data from multiple points in time to establish the expected temporal relationship between experiences with COVID-19 and support for health reform. Finally, consistent with the importance of health issues in the 2020 presidential race, we find that changes in support for health reform were mirrored by a comparable shift in support away from the incumbent, President Trump, in the weeks leading up to the election. Even if short lived, these shifts may have influenced both the discourse and outcome of the election.
The Impact of the Opioid Crisis on Firm Value and Investment
Authors: Ouimet Paige , Simintzi Elena , Ye Kailei 
Published: February 2025

Abstract
We show a negative effect of opioid prescriptions on subsequent individual employment among employers in our sample using doctor-opioid-prescribing propensity as our instrument. This finding has implications for firms that must now contend with lower local labor supply. We find a negative relationship between opioid prescriptions and subsequent establishment growth. However, firms respond to labor shortages by investing more in technology, replacing the relatively scarcer labor with capital, especially when they are not financially constrained. We find positive abnormal returns, upon the passage of state laws intended to limit opioid prescriptions, that are driven by firms more reliant on labor. (JEL J21, G31, 033)
Development and multicenter validation of machine learning models for predicting postoperative pulmonary complications after neurosurgery
Authors: Xu Ming , Zhu Wenhao , Hou Siyu , Xu Hongzhi , Xia Jingwen , Lin Liyu , Fu Hao , You Mingyu , Wang Jiafeng , Xie Zhi , Wen Xiaohong , Wang Yingwei 
Published: February 2025

Abstract

Background:
Postoperative pulmonary complications (PPCs) are major adverse events in neurosurgical patients. This study aimed to develop and validate machine learning models predicting PPCs after neurosurgery.

Methods:
PPCs were defined according to the European Perioperative Clinical Outcome standards as occurring within 7 postoperative days. Data of cases meeting inclusion/exclusion criteria were extracted from the anesthesia information management system to create three datasets: The development (data of Huashan Hospital, Fudan University from 2018 to 2020), temporal validation (data of Huashan Hospital, Fudan University in 2021) and external validation (data of other three hospitals in 2023) datasets. Machine learning models of six algorithms were trained using either 35 retrievable and plausible features or the 11 features selected by Lasso regression. Temporal validation was conducted for all models and the 11-feature models were also externally validated. Independent risk factors were identified and feature importance in top models was analyzed.

Results:
PPCs occurred in 712 of 7533 (9.5%), 258 of 2824 (9.1%), and 207 of 2300 (9.0%) patients in the development, temporal validation and external validation datasets, respectively. During cross-validation training, all models except Bayes demonstrated good discrimination with an area under the receiver operating characteristic curve (AUC) of 0.84. In temporal validation of full-feature models, deep neural network (DNN) performed the best with an AUC of 0.835 (95% confidence interval [CI]: 0.805–0.858) and a Brier score of 0.069, followed by logistic regression (LR), random forest and XGBoost. The 11-feature models performed comparable to full-feature models with very close but statistically lower AUCs, with the top models of DNN and LR in temporal and external validations. An 11-feature nomogram was drawn based on the LR algorithm and it outperformed the minimally modified Assess respiratory RIsk in Surgical patients in CATalonia (ARISCAT) and Laparoscopic Surgery Video Educational Guidelines (LAS VEGAS) scores with a higher AUC (LR: 0.824, ARISCAT: 0.672, LAS: 0.663). Independent risk factors based on multivariate LR mostly overlapped with Lasso-selected features, but lacked consistency with the important features using the Shapley additive explanation (SHAP) method of the LR model.

Conclusions:
The developed models, especially the DNN model and the nomogram, had good discrimination and calibration, and could be used for predicting PPCs in neurosurgical patients. The establishment of machine learning models and the ascertainment of risk factors might assist clinical decision support for improving surgical outcomes.

Trial registration:
ChiCTR 2100047474; https://www.chictr.org.cn/showproj.html?proj = 128279.
Concepts in Cutaneous Vasculitis
Authors: Fernandez-Flores Angel 
Published: February 2025

Abstract:
Skin biopsy plays a fundamental role in the diagnosis of vasculitis. However, the general pathologist or dermatopathologist who encounters these diagnostic findings in their early stages often faces the paradox that the clinician requests the exclusion of various systemic diseases, when the biopsy only shows leukocytoclastic vasculitis. In other cases, even though the affected vessels are small, some of them seem deep within the biopsy, raising differential diagnosis with several entities of systemic repercussion. Lastly, although the dermatopathologist has a histological picture before them, they are often required to correlate it with laboratory data such as the presence of antineutrophil antibodies, for example. Therefore, the objective of this article is conceptual, emphasizing those basic aspects that can contribute to a better understanding and diagnosis of skin biopsy in vasculitis.
The History of Neuromodulators in Dermatologic Surgery
Authors: Cespedes Zablah Andrea , Matarasso Seth L. , Carruthers Jean 
Published: February 2025

BACKGROUND
In 1817 and 1820, the German physician Justinus Kerner published a series of cases of lethal food poisoning that would unknowingly have a lasting impact on medical science. His compilation of over 75 cases linked the consumption of smoked sausages in the small town of Herrenberg in Württemberg, recounted a constellation of symptoms that today the authors call botulism. Now, over 2 centuries later, the discovery, study and refinement of the toxin causing clinical botulism has led to the acceptance of neuromodulators as a treatment for a wide variety of medical concerns.

OBJECTIVE
The aim of this article is to understand the many historical advances in the mechanism of action of botulinum neurotoxins, the wide range of indications that are currently available and Dermatologic Surgery's role in this evolution.

MATERIALS AND METHODS
A PubMed retrospective search to identify literature on the history of botulinum toxin was undertaken.

RESULTS
Botulinum toxin is the newest therapeutic generational drug with over 30 approved indications in 90 countries. There are now 7 FDA (food and drug administration) approved neuromodulators with several more under current review. CONCLUSION
Dermatologic Surgery has had a seminal role in the advancement of neuromodulators and publishing associated literature.
Therapeutic Applications of Hair Follicle Transplantation Beyond Hair Restoration
Authors: Laufer-Britva Rimma , Vathananai Wipawan , Jimenez Francisco 
Published: February 2025

BACKGROUND
Hair follicle (HF) transplantation, especially through follicular unit excision (FUE), is renowned for treating androgenetic alopecia. Recent advancements have expanded its use in dermatology and plastic surgery.

OBJECTIVE
This review explores FUE's broader applications beyond hair restoration, including its efficacy in treating chronic ulcers, axillary hyperhidrosis, bromhidrosis, vitiligo, and scar remodeling.

METHODS
A comprehensive literature review was conducted using key medical databases, focusing on clinical research such as randomized controlled trials, retrospective studies, case series, and reports, while excluding review articles and commentaries.

RESULTS
Hair follicle transplantation using the FUE technique has shown significant promise in enhancing healing in chronic ulcers and difficult to heal wounds, with cases demonstrating complete wound healing across various ulcer types. The method of sweat gland removal using FUE micropunches substantially reduced sweating and malodor in patients with axillary hyperhidrosis and bromhidrosis. In vitiligo treatment, FUE combined with other therapies showed promising repigmentation results.

CONCLUSION
Follicular unit excision emerges as a versatile surgical technique demonstrating potential in various conditions beyond alopecia. The minimal complications associated with FUE across various applications highlight its safety profile. Its expanding scope in medical applications calls for further research and clinical trials to optimize its use and understand its full therapeutic potential.
Mechanically Powered Negative Pressure Dressing Enhances Surgical Incision Cosmesis: A Randomized Trial
Authors: Williams Brian , Gupta Abhinav , Martucci Jordan , Swinford Aubrey , Cologne Kyle G. , Koller Sarah E. , Shin Joongho 
Published: February 2025

Background:
Cosmetic appearance of incisions remains one of the most important aspects of the patient recovery experience. Despite advances in surgery, scar prevention is the gold standard in improved results. Closed-incision negative pressure wound therapy has shown promise in decreasing surgical site infection and healing time. This study aimed to assess outcomes of primarily closed surgical incisions with mechanically powered negative pressure dressings (MP-NPDs) compared with standard dressings.

Methods:
This study was a single-center, within-subjects, randomized controlled trial, in which each patient served as both the control and experimental arms. Laparoscopic/robotic port site incisions were randomized to control dressing or MP-NPD. Primary outcomes were cosmetic results at first clinic visit by blinded physicians and nonphysician observers.

Results:
Forty patients with a total of 80 incisions were included in the analysis. The average scores for scar spread, erythema, dyspigmentation, scar hypertrophy, and overall impression were lower for the MP-NPD wounds. The only individual variable of the Scar Cosmesis Assessment Rating scale, in which there was no difference noted between the 2 groups, was the presence of suture marks. The average total Scar Cosmesis Assessment Rating score was significantly lower (more favorable) for the MP-NPD wounds compared with the control wounds (3.39 ± 3.18 versus 4.79 ± 3.18, respectively; P < 0.001).

Conclusions:
The use of closed-incision negative pressure wound therapy with the application of a novel MP-NPD over surgical incisions resulted in clinical and statistically significant improvement in scar cosmesis in the early/intermediate postoperative period according to both physician and nonphysician observers.