bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Interleukin-2 to the Bone Marrow Stroma for Therapy of Acute Myeloid Leukemia Relapsing after Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Schliemann Christoph , Gutbrodt Katrin L. , Kerkhoff Andrea , Pohlen Michele , Wiebe Stefanie , Silling Gerda , Angenendt Linus , Kessler Torsten , Mesters Rolf M. , Giovannoni Leonardo , Schäfers Michael , Altvater Bianca , Rossig Claudia , Grünewald Inga , Wardelmann Eva , Köhler Gabriele , Neri Dario , Stelljes Matthias , Berdel Wolfgang E. 
Published: February 2015

Abstract
The antibody-based delivery of IL2 to extracellular targets expressed in the easily accessible tumor-associated vasculature has shown potent antileukemic activity in xenograft and immunocompetent murine models of acute myelogenous leukemia (AML), especially in combination with cytarabine. Here, we report our experience with 4 patients with relapsed AML after allogeneic hematopoietic stem cell transplantation (allo-HSCT), who were treated with the immunocytokine F16-IL2, in combination with low-dose cytarabine. One patient with disseminated extramedullary AML lesions achieved a complete metabolic response identified by PET/CT, which lasted 3 months. Two of 3 patients with bone marrow relapse achieved a blast reduction with transient molecular negativity. One of the 2 patients enjoyed a short complete remission before AML relapse occurred 2 months after the first infusion of F16-IL2. In line with a site-directed delivery of the cytokine, F16-IL2 led to an extensive infiltration of immune effector cells in the bone marrow. Grade 2 fevers were the only nonhematologic side effects in 2 patients. Grade 3 cytokine-release syndrome developed in the other 2 patients but was manageable in both cases with glucocorticoids. The concept of specifically targeting IL2 to the leukemia-associated stroma deserves further evaluation in clinical trials, especially in patients who relapse after allo-HSCT. Cancer Immunol Res; 3(5); 547–56. ©2015 AACR.
Racial Disparities in Outcomes of Adult Heart Transplantation
Authors: Kilic Arman , Higgins Robert S. D. , Whitson Bryan A. , Kilic Ahmet 
Published: February 2015

Background—
This study evaluated whether minority orthotopic heart transplant (OHT) recipients tend to be transplanted at worse performing centers.

Methods and Results—

OHT recipients between 2000 and 2010 were identified in the United Network for Organ Sharing database and stratified by race. Center performance was evaluated using observed-to-expected mortality ratios that were calculated using validated indexes for recipient and donor risk in OHT. The primary outcome was 1-year post-OHT mortality. A total of 102 centers performed OHT in 18 085 patients. Blacks had higher unadjusted 1-year mortality, which was confirmed after risk adjustment. Blacks had increased risk-adjusted mortality at poor performing centers (observed-to-expected mortality ratio, >1.2; odds ratio, 1.37 [95% confidence interval, 1.12–1.69];
P
=0.002) and a strong trend toward increased mortality at excellent performing centers (observed-to-expected mortality ratio, <0.8; odds ratio, 1.42 [95% confidence interval, 0.99–2.02];
P
=0.06). A higher proportion of blacks were treated at centers with higher-than-expected mortality (56.4% versus 47.1% whites versus 48.1% Hispanics;
P
<0.001), a finding that persisted after adjusting for insurance type and highest education level. In addition, there was a positive correlation between the percentage of blacks and observed-to-expected mortality ratios at the center level (
r
=0.32;
P
=0.001). In multivariable analysis incorporating immunologic and socioeconomic variables, there was no clear dominant source for the disparities in outcomes of OHT between races.

Conclusions—
Blacks have a propensity to be transplanted at worse performing centers; however, center effect alone does not explain the mortality difference between ethnicities. Although referral of minorities to better performing centers would improve absolute survival, it would not likely eliminate the racial disparities that exist in OHT outcomes.
Rapid and Body Weight–Independent Improvement of Endothelial and High-Density Lipoprotein Function After Roux-en-Y Gastric Bypass
Authors: Osto Elena , Doytcheva Petia , Corteville Caroline , Bueter Marco , Dörig Claudia , Stivala Simona , Buhmann Helena , Colin Sophie , Rohrer Lucia , Hasballa Reda , Tailleux Anne , Wolfrum Christian , Tona Francesco , Manz Jasmin , Vetter Diana , Spliethoff Kerstin , Vanhoutte Paul M. , Landmesser Ulf , Pattou Francois , Staels Bart , Matter Christian M. , Lutz Thomas A. , Lüscher Thomas F. 
Published: February 2015

Background—
Roux-en-Y gastric bypass (RYGB) reduces body weight and cardiovascular mortality in morbidly obese patients. Glucagon-like peptide-1 (GLP-1) seems to mediate the metabolic benefits of RYGB partly in a weight loss–independent manner. The present study investigated in rats and patients whether obesity-induced endothelial and high-density lipoprotein (HDL) dysfunction is rapidly improved after RYGB via a GLP-1–dependent mechanism.

Methods and Results—

Eight days after RYGB in diet-induced obese rats, higher plasma levels of bile acids and GLP-1 were associated with improved endothelium-dependent relaxation compared with sham-operated controls fed ad libitum and sham-operated rats that were weight matched to those undergoing RYGB. Compared with the sham-operated rats, RYGB improved nitric oxide (NO) bioavailability resulting from higher endothelial Akt/NO synthase activation, reduced c-Jun amino terminal kinase phosphorylation, and decreased oxidative stress. The protective effects of RYGB were prevented by the GLP-1 receptor antagonist exendin
9-39
(10 μg·kg
−1
·h
−1
). Furthermore, in patients and rats, RYGB rapidly reversed HDL dysfunction and restored the endothelium-protective properties of the lipoprotein, including endothelial NO synthase activation, NO production, and anti-inflammatory, antiapoptotic, and antioxidant effects. Finally, RYGB restored HDL-mediated cholesterol efflux capacity. To demonstrate the role of increased GLP-1 signaling, sham-operated control rats were treated for 8 days with the GLP-1 analog liraglutide (0.2 mg/kg twice daily), which restored NO bioavailability and improved endothelium-dependent relaxations and HDL endothelium-protective properties, mimicking the effects of RYGB.

Conclusions—
RYGB rapidly reverses obesity-induced endothelial dysfunction and restores the endothelium-protective properties of HDL via a GLP-1–mediated mechanism. The present translational findings in rats and patients unmask novel, weight-independent mechanisms of cardiovascular protection in morbid obesity.
Drip and Ship Thrombolytic Therapy for Acute Ischemic Stroke
Authors: Sheth Kevin N. , Smith Eric E. , Grau-Sepulveda Maria V. , Kleindorfer Dawn , Fonarow Gregg C. , Schwamm Lee H. 
Published: February 2015

Background and Purpose—
Interhospital transfer after use of intravenous tissue-type plasminogen activator (tPA) in acute stroke (drip and ship) is increasingly frequent. Small studies have suggested that drip and ship tPA is safe and increases rates of tPA use; however, little is known about real-world practice patterns. We sought to evaluate temporal trends in drip and ship tPA use and to compare the patient and hospital characteristics with that of conventional (front door) thrombolysis.

Methods—
We analyzed data from 44 667 patients with ischemic stroke treated with intravenous tPA ≤3 hours of symptom onset in the Get With The Guidelines-Stroke program from April 2003 to October 2010 in 1440 hospitals. The main outcomes were the frequency of drip and ship tPA use over time, the characteristics of patients treated, and in-hospital outcomes, treatments, and complications.

Results—
Among 44 667 patients treated with tPA, the drip and ship method was a common method (n=10 475; 23.5%), the use of which increased in parallel with the traditional tPA method over time. Patients treated by the drip and ship method differed significantly from front-door patients, with lower National Institutes of Health Stroke Scale scores when recorded (n=35 467). Crude in-hospital mortality (10.9%) and symptomatic intracranial hemorrhage (5.7%) in patients treated by the drip and ship method were slightly higher compared with those in front-door patients, and these differences persisted after risk adjustment.

Conclusions—
Drip and ship tPA is common, used in 1 in 4 patients treated with tPA in the United States. Modest differences in mortality and symptomatic intracranial hemorrhage may be because of patient selection bias, post-tPA care differences, or unmeasured confounding. The drip and ship paradigm may facilitate widespread tPA use in patients with acute stroke.
Combined Winds and Turbulence Prediction System for Automated Air-Traffic Management Applications
Authors: Kim Jung-Hoon , Chan William N. , Sridhar Banavar , Sharman Robert D. 
Published: February 2015

AbstractA time-lagged ensemble of energy dissipation rate (EDR)-scale turbulence metrics is evaluated against in situ EDR observations from commercial aircraft over the contiguous United States and applied to air-traffic management (ATM) route planning. This method uses the Graphic Turbulence Guidance forecast methodology with three modifications. First, it uses the convection-permitting-scale (Δx = 3 km) Advanced Research version of the Weather Research and Forecasting Model (ARW) to capture cloud-resolving-scale weather phenomena. Second, turbulence metrics are computed for multiple ARW forecasts that are combined at the same forecast valid time, resulting in a time-lagged ensemble of multiple turbulence metrics. Third, probabilistic turbulence forecasts are provided on the basis of the ensemble results, which are applied to the ATM route planning. Results show that the ARW forecasts match well with observed weather patterns and the overall performance skill of the ensemble turbulence forecast when compared with the observed data is superior to any single turbulence metric. An example wind-optimal route (WOR) is computed using areas experiencing ≥10% probability of encountering severe-or-greater turbulence. Using these turbulence data, lateral turbulence avoidance routes starting from three different waypoints along the WOR from Los Angeles International Airport to John F. Kennedy International Airport are calculated. The examples illustrate the trade-off between flight time/fuel used and turbulence avoidance maneuvers.
Physical Mechanisms of Summer Precipitation Variations in the Tarim Basin in Northwestern China
Authors: Huang Wei , Feng Song , Chen Jianhui , Chen Fahu 
Published: February 2015

Abstract
The Tarim basin (TB) in northwestern China is one of the most arid regions in the middle latitudes, where water is scarce year-round. This study investigates the variations of summer precipitation in the TB and their association with water vapor fluxes and atmospheric circulation. The results suggest that the variations of summer precipitation in the TB are dominated by the water vapor fluxes from the south and east, although the long-term mean water vapor mostly comes from the west. The anomalous water vapor fluxes are closely associated with the meridional teleconnection pattern around 50°–80°E and the zonal teleconnection pattern along the Asian westerly jet in summer. The meridional teleconnection connects central Asia and the tropical Indian Ocean; the zonal teleconnection resembles the “Silk Road pattern.” The two teleconnections lead to negative height anomalies in central Asia and positive height anomalies in the Arabian Sea and India and in northern central China. The anomalous pressure gradient force, caused by these height anomalies, leads to anomalous ascending motion in the TB and brings low-level moisture along the eastern periphery of the Tibetan Plateau and water vapor from the Arabian Sea passing over the Tibetan Plateau to influence precipitation development in the study region.
Seasonal Predictability of Extratropical Storm Tracks in GFDL’s High-Resolution Climate Prediction Model
Authors: Yang Xiaosong , Vecchi Gabriel A. , Gudgel Rich G. , Delworth Thomas L. , Zhang Shaoqing , Rosati Anthony , Jia Liwei , Stern William F. , Wittenberg Andrew T. , Kapnick Sarah , Msadek Rym , Underwood Seth D. , Zeng Fanrong , Anderson Whit , Balaji Venkatramani 
Published: February 2015

Abstract
The seasonal predictability of extratropical storm tracks in the Geophysical Fluid Dynamics Laboratory’s (GFDL)’s high-resolution climate model has been investigated using an average predictability time analysis. The leading predictable components of extratropical storm tracks are the ENSO-related spatial patterns for both boreal winter and summer, and the second predictable components are mostly due to changes in external radiative forcing and multidecadal oceanic variability. These two predictable components for both seasons show significant correlation skill for all leads from 0 to 9 months, while the skill of predicting the boreal winter storm track is consistently higher than that of the austral winter. The predictable components of extratropical storm tracks are dynamically consistent with the predictable components of the upper troposphere jet flow for both seasons. Over the region with strong storm-track signals in North America, the model is able to predict the changes in statistics of extremes connected to storm-track changes (e.g., extreme low and high sea level pressure and extreme 2-m air temperature) in response to different ENSO phases. These results point toward the possibility of providing skillful seasonal predictions of the statistics of extratropical extremes over land using high-resolution coupled models.
Airborne Spectral Polarimeter for Ocean Wave Research
Authors: Hooper Brett A. , Van Pelt Becky , Williams J. Z. , Dugan J. P. , Yi M. , Piotrowski C. C. , Miskey C. 
Published: February 2015

AbstractThe Airborne Remote Optical Spotlight System (AROSS) family of sensors consists of airborne imaging systems that provide passive, high-dynamic range, time series image data and has been used successfully to characterize currents and bathymetry of nearshore ocean, tidal flat, and riverine environments. AROSS–multispectral polarimeter (AROSS-MSP) is a 12-camera system that extends this time series capability to simultaneous color and polarization measurements for the full linear polarization of the imaged scene in red, green, and blue, and near-infrared (RGB–NIR) wavelength bands. Color and polarimetry provide unique information for retrieving dynamic environmental parameters over a larger area (square kilometers) than is possible with typical in situ measurements. This particular field of optical remote sensing is developing rapidly, and simultaneous color and polarimetric data are expected to enable the development of a number of additional important environmental data products, such as the improved ability to image the subsurface water column or maximizing wave contrast to improve oceanographic parameter retrievals of wave spectra and wave heights.One of the main obstacles to providing good-quality polarimetric image data from a multicamera system is the ability to accurately merge imagery from the cameras to a subpixel level. This study shows that the imagery from AROSS-MSP can be merged to an accuracy better than one-twentieth of a pixel, comparing two different automated algorithmic techniques. This paper describes the architecture of AROSS-MSP, the approach for providing simultaneous color and polarization imagery in space and time, an error analysis to characterize the measurements, and example color and polarization data products from ocean wave imagery.
The bromocresol green assay, but not the modified bromocresol purple assay, overestimates the serum albumin concentration in nephrotic syndrome through reaction with α2-macroglobulin
Authors: Ueno Tsuyoshi , Hirayama Satoshi , Sugihara Masami , Miida Takashi 
Published: February 2015

Background The bromocresol green (BCG) assay is commonly used for measuring albumin (ALB), but is affected by α1- and α2-globulins, which are elevated in systemic inflammation. The modified bromocresol purple (mBCP) assay is another dye-binding method developed to overcome non-specific reactions. Concentrations of α2-macroglobulin, a major α2-globulin component, are increased in nephrotic syndrome (NS), but not in inflammation. There is little direct evidence that α2-macroglobulin affects BCG or mBCP assays. Methods We measured serum albumin concentrations in 33 patients with NS and 13 reference healthy controls using BCG (ALBBCG) and mBCP (ALBmBCP) assays, and nephelometry (nALB) as a reference method. We also determined five specific proteins belonging to the α1- and α2-globulins by nephelometry. After adding purified α2-macroglobulin to albumin solutions, protein reactivity in these three assays was compared. Results Nephrotic syndrome patients were categorized to tertiles according to nALB concentration. In all tertiles, ALBBCG was significantly higher than nALB, especially in the severe hypoalbuminemia group, in which α2-macroglobulin was 43–49% higher. By contrast, ALBmBCP and nALB were almost identical in all three groups. The difference between ALBBCG and nALB was positively correlated with the α2-macroglobulin concentration. In vitro, when α2-macroglobulin was added to solutions containing identical albumin concentrations, α2-macroglobulin dose-dependently increased ALBBCG, but not ALBmBCP. Conclusions In NS, α2-macroglobulin is a major factor for positive bias of ALBBCG, especially in patients with severe hypoalbuminemia. The mBCP assay is useful for measuring albumin concentrations in NS.
Implementing participatory research with an urban American Indian community: Lessons learned
Authors: Roberts Erica B , Jette Shannon L 
Published: February 2015

Objective: Participatory research has proven an effective method for improving health equity among American Indians/Alaska Natives (AI/ANs) by addressing power imbalances between communities and researchers, incorporating community knowledge and theory, ensuring mutual benefit and improving community capacity and programme sustainability. However, few studies have examined the implementation of these methods with urban Indian (UI) communities, a growing population currently comprising 71% of AI/ANs. This paper describes the experiences of two academic researchers (one a Native doctoral student and another a White assistant professor) who sought to engage in participatory research with an UI community in Maryland. Method: The methodology employed was a literature review of Indigenous participatory research methods that aimed to inform the work of a youth-led project, and a reflexive case-study analysis. Results: Researchers discuss the social, structural and political inequalities that challenged their ability to engage in this process and identify three lessons learned associated with conducting participatory research with this population: logistics and recruitment, identifying the constraints and/or competing priorities of the community, and the importance of reflexivity and communication throughout the process. In an epilogue, the researchers highlight and reflect upon how they have since applied these lessons to strengthen their relationship with the community, yielding new and mutually beneficial participatory research projects. Conclusion: The findings presented advance research on participatory methodologies with UI communities and call for increased economic and political support of and long-term commitment to UI organisations to address the structural inequalities underpinning existing health inequities.
Effects of Stereoscopic Depth on Vigilance Performance and Cerebral Hemodynamics
Authors: Greenlee Eric T. , Funke Gregory J. , Warm Joel S. , Finomore Victor S. , Patterson Robert E. , Barnes Laura E. , Funke Matthew E. , Vidulich Michael A. 
Published: February 2015

Objective: We tested the possibility that monitoring a display wherein critical signals for detection were defined by a stereoscopic three-dimensional (3-D) image might be more resistant to the vigilance decrement, and to temporal declines in cerebral blood flow velocity (CBFV), than monitoring a display featuring a customary two-dimensional (2-D) image. Background: Hancock has asserted that vigilance studies typically employ stimuli for detection that do not exemplify those that occur in the natural world. As a result, human performance is suboptimal. From this perspective, tasks that better approximate perception in natural environments should enhance performance efficiency. To test that possibility, we made use of stereopsis, an important means by which observers interact with their everyday surroundings. Method: Observers monitored a circular display in which a vertical line was embedded. Critical signals for detection in a 2-D condition were instances in which the line was rotated clockwise from vertical. In a 3-D condition, critical signals were cases in which the line appeared to move outward toward the observer. Results: The overall level of signal detection and the stability of detection over time were greater when observers monitored for 3-D changes in target depth compared to 2-D changes in target orientation. However, the 3-D display did not retard the temporal decline in CBFV. Conclusion: These results provide the initial demonstration that 3-D displays can enhance performance in vigilance tasks. Application: The use of 3-D displays may be productive in augmenting system reliability when operator vigilance is vital.
Initial experience of direct-to-test endoscopic ultrasonography for suspected choledocholithiasis
Authors: Lochhead Paul , Phull Perminder 
Published: February 2015

Background and aims Endoscopic ultrasound has become an invaluable tool in the investigation of patients with suspected pancreatobiliary disease. We set out to determine whether a “direct-to-test” endoscopic ultrasound procedure could be offered to selected patients with suspected choledocholithiasis. Methods and results We included patients referred to our general gastroenterology service with clinical history, symptomatology and/or laboratory results compatible with choledocholithiais. Almost all patients had already had a transabdominal ultrasound performed at the request of their general practitioner. All patients underwent direct-to-test day-case endoscopic ultrasound under conscious sedation. Procedures were performed by a single practitioner using an oblique-viewing radial echoendoscope. The diagnostic yield and frequencies of discharge, onward referral and follow-up were determined. Overall diagnostic yield of direct-to-test endoscopic ultrasound was 61%. The most common diagnoses were cholelithiasis (18%) and choledocholithiasis (11%); one periampullary cancer was also detected. A definitive outcome (discharge or referral for a therapeutic procedure) occurred in 14 of 28 patients (50%). The remaining 14 patients underwent further out-patient evaluation. Eventual diagnoses in this group included autoimmune hepatitis, primary biliary cirrhosis and drug-induced hepatitis. Conclusions For patients with suspected biliary disease, direct-to-test endoscopic ultrasound has a high diagnostic yield, and may be an appropriate mode of investigation.