bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemeriksaan Skrining Anemia pada Remaja Putri di Pondok Pesantren Sabilul Ulum Al-Hidayah Wonoayu
Authors: Nugraha Gilang , Romdloni Muhammad Afwan , Kurniasari Diyan Wahyu 
Published: July 2024

ABSTRAK Prevalensi anemia pada remaja putri pada kelompok usia 15-24 tahun di Indonesia berkisar 27,2%. Pondok pesantren Sabilul Ulum Al-Hidayah memiliki banyak santriwati pada usia remaja yang juga membutuhkan asupan gizi salah satunya untuk pembentukan hemoglobin agar tercukupi. Tujuan untuk melakukan pemeriksaan hemoglobin untuk skrining anemia. Pengabdian Masyarakat dilakukan dengan observasi langsung melalui wawancara dan pemeriksaan hemoglobin menggunakan POCT. Data disajikan dalam bentuk frekuensi. Jumlah santriwati yang mengikuti kegiatan pengabdian Masyarakat yaitu 32 orang dengan rentang umur 13 – 17 tahun. Sebagian besar santriwati tidak sedang diet atau melakukan puasa secara rutin (22 orang) dan sebagian besar tidak sedang menstruasi (24 orang). Santriwati yang mengalami anemia yaitu sebanyak 10 orang. Telah terjaring sebanyak 10 santriwati yang mengalami anemia, dan 5 diantaranya sedang mengalami menstruasi. Kata kunci: Anemia, Hemoglobin, POCT, santriwati ABSTRACT The prevalence of anemia in young women in the 15–24 year age group in Indonesia is around 27.2%. The Sabilul Ulum Al-Hidayah Islamic boarding school has many female students in their teens who also need adequate nutritional intake, one of which is for the formation of hemoglobin. Purpose to Perform a hemoglobin test to screen for anemia. Community Service is carried out by direct observation through interviews and hemoglobin examination using POCT. Data is presented in frequency form. The number of female students taking part in community service activities is 32 people with an age range of 13 - 17 years. Most of the female students were not on a diet or fasting regularly (22 people) and most were not menstruating (24 people). There were 10 female students who experienced anemia. There were 10 female students who were anemic, and 5 of them were menstruating. Keywords: Anemia, Hemoglobin, POCT, Female Students
Hubungan Dukungan Keluarga dengan Tingkat Spiritual Pada Pasien Gagal Ginjal Kronik di Ruang Hemodialisa RSU Royal Prima Medan
Authors: Gea Erna Lilis Sofianti , Hutapea Indra Wahyuni , Sitopu Robin Ferdiansyah 
Published: July 2024

ABSTRACK Chronic Kidney Failure is the most common disease currently suffered with the 20th highest death rate in the world. Family support is a very crucial solution when facing problems, especially health problems, and patients undergoing treatment really need to fulfill their spiritual needs to overcome feelings of despair, anxiety, protection, uprooting, loss and death. This research is to determine the relationship between family support and spiritual level in chronic kidney failure patients in the hemodialysis room. This survey uses an analytical observation method with a cross sectional approach. The total number of patients undergoing Hemodialysis at the Royal Prima Medan Hospital in October 2023 was 134 people. The sampling technique used in this survey was purposive sampling with a total sample of 36 respondents. Spearman rho test obtained correlation results (0.576) with a significance value of 1%. These results prove that there is a fairly strong correlation between the relationship between family support and the spiritual level of patients in the hemodialysis room. Keyword: Family Support, Spiritual Level, Chronik Kidney Failure ABSTRAK Gagal Ginjal Kronik merupakan penyakit paling banyak diderita saat ini dengan angka kematian tertinggi ke-20 didunia. Dukungan keluarga merupakan salah satu solusi yang sangat krusial ketika menghadapi permasalahan khususnya permasalahan kesehatan dan Pasien yang menjalani pengobatan sangat perlu memenuhi kebutuhan spiritualitasnya untuk mengatasi perasaan putus san, cemas, terisolasi, ketidakpastian, kehilangan dan kematian. penelitian ini untuk mengidentifikasi hubungan dukungan keluarga dengan tingkat spiritual pada pasien gagal ginjal kronik di ruang hemodialisa. survey ini memanfaatkan metode observasi analitik dengan pendekatan cross sectional. Total pasien yang melaksanakn Hemodialisa di Rumah Sakit Royal Prima Medan dibulan oktober 2023 sebanyak 134 orang. Teknik sampling yang digunakan pada survey ini merupakan purposive sampling dengan total sampel berjumlah 36 responden. Uji spearman rho didapatkan hasil korelasi (0,576) dengan nilai signifikasi 1%. Dari hasil tersebut membuktikan bahwa adanya kolerasi yang cukup kuat antara Hubungan Dukungan Keluarga dengan Tingkat Spiritual Pada Pasien di Ruang Hemodialisa. Kata Kunci: Dukungan Keluarga, Tingkat Spiritual, Gagal Ginjal Kronik
Analisis Faktor Determinan Status Gizi Balita: A Systematic Review
Authors: Sembiring Anita Christina 
Published: July 2024

Pendahuluan: Sebagai generasi penerus bangsa, kesehatan anak harus mendapatkan perhatian khusus. Masalah gizi pada anak selalu menjadi masalah kesehatan masyarakat yang utama di seluruh dunia. Ada 149,2 juta anak di bawah usia lima tahun mengalami stunting; 45,4 juta anak kurus dan 38,9 juta anak kelebihan berat badan. Malnutrisi masih menjadi masalah kesehatan masyarakat yang kritis pada anak anak di bawah usia lima tahun di negara negara berkembang. Berbagai penelitian menunjukkan bahwa faktor yang berhubungan dengan masalah gizi pada anak berbeda beda pada tiap negara. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang berhubungan dengan status gizi pada balita. Penelitian ini menggunakan systematic review yang disusun berdasarkan Preferred reporting Items for Systematic Reviews and MetaAanalyzes (PRISMA). Pencarian artikel menggunakan tiga database yaitu PubMed, Science Direct dan Scopus. Kriteria inklusi penelitian ini adalah artikel yang diterbitkan pada tahun 2013-2023 dan open accses, sampelnya adalah anak balita. Hasil telaah dari 22 artikel di dapatkan bahwa faktor determinan terhadap status gizi balita adalah karakteristik orang tua meliputi pendidikan ibu, pekerjaan ibu, usia ibu, IMT ibu, pengetahuan ibu; karakteristik keluarga meliputi: jumlah anak dan social ekonomi keluarga; faktor penyakit seperti diare dan BBLR serta faktor hygiene sanitasi meliputi ketersediaan air bersih dan toilet serta fasilitas pelayanan kesehatan.

Kata Kunci:
balita, factor determinan, status gizi
Integrative approach to pedobarography and pelvis-trunk motion for knee osteoarthritis detection and exploration of non-radiographic rehabilitation monitoring
Authors: Sarmah Arnab , Boruah Lipika , Ito Satoshi , Kanagaraj Subramani 
Published: July 2024

BackgroundOsteoarthritis (OA) is a highly prevalent global musculoskeletal disorder, and knee OA (KOA) accounts for four-fifths of the cases worldwide. It is a degenerative disorder that greatly affects the quality of life. Thus, it is managed through different methods, such as weight loss, physical therapy, and knee arthroplasty. Physical therapy aims to strengthen the knee periarticular muscles to improve joint stability.MethodsPedobarographic data and pelvis and trunk motion of 56 adults are recorded. Among them, 28 subjects were healthy, and 28 subjects were suffering from varying degrees of KOA. Age, sex, BMI, and the recorded variables are used together to identify subjects with KOA using machine learning (ML) models, namely, logistic regression, SVM, decision tree, and random forest. Surface electromyography (sEMG) signals are also recorded bilaterally from two muscles, the rectus femoris and biceps femoris caput longus, bilaterally during various activities for two healthy and six KOA subjects. Cluster analysis is then performed using the principal components obtained from time-series features, frequency features, and time–frequency features.ResultsKOA is successfully identified using the pedobarographic data and the pelvis and trunk motion with the highest accuracy and sensitivity of 89.3% and 85.7%, respectively, using a decision tree classifier. In addition, sEMG data have been successfully used to cluster healthy subjects from KOA subjects, with wavelet analysis features providing the best performance for the standing activity under different conditions.ConclusionKOA is detected using gait variables not directly related to the knee, such as pedobarographic measurements and pelvis and trunk motion captured by pedobarography mats and wearable sensors, respectively. KOA subjects are also distinguished from healthy individuals through clustering analysis using sEMG data from knee periarticular muscles during walking and standing. Gait data and sEMG complement each other, aiding in KOA identification and rehabilitation monitoring. It is important because wearable sensors simplify data collection, require minimal sample preparation, and offer a non-radiographic, safe method suitable for both laboratory and real-world scenarios. The decision tree classifier, trained with stratified k-fold cross validation (SKCV) data, is observed to be the best for KOA identification using gait data.
PDIA iminosugar influence on subcutaneous Staphylococcus aureus and Pseudomonas aeruginosa infections in mice
Authors: Kozień Łucja , Policht Aleksandra , Heczko Piotr , Arent Zbigniew , Bracha Urszula , Pardyak Laura , Pietsch-Fulbiszewska Agnieszka , Gallienne Estelle , Piwowar Piotr , Okoń Krzysztof , Tomusiak-Plebanek Anna , Strus Magdalena 
Published: July 2024

IntroductionBiofilm-associated infections persist as a therapeutic challenge in contemporary medicine. The efficacy of antibiotic therapies is ineffective in numerous instances, necessitating a heightened focus on exploring novel anti-biofilm medical strategies. Among these, iminosugars emerge as a distinctive class of compounds displaying promising biofilm inhibition properties.MethodsThis study employs an in vivo wound infection mouse model to evaluate the effectiveness of PDIA in treating biofilm-associated skin wound infections caused by Staphylococcus aureus and Pseudomonas aeruginosa. Dermic wounds in mice were infected with biofilm-forming strains, specifically S. aureus 48 and P. aeruginosa 5, which were isolated from patients with diabetic foot, and are well-known for their strong biofilm formation. The subsequent analysis included clinical, microbiological, and histopathological parameters. Furthermore, an exploration into the susceptibility of the infectious strains to hydrogen peroxide was conducted, acknowledging its potential presence during induced inflammation in mouse dermal wounds within an in vivo model.ResultsThe findings revealed the efficacy of PDIA iminosugar against the S. aureus strain, evidenced by a reduction in bacterial numbers within the wound and the inflammatory focus.DiscussionThis study suggests that PDIA iminosugar emerges as an active and potentially effective antibiofilm agent, positioning it as a viable treatment option for staphylococcal infections.
Elementary students’ shared understanding of angle during an educational robotics task
Authors: Simpson Amber , Shokeen Ekta , Katirci Nihal , Williams-Pierce Caro 
Published: July 2024

IntroductionPrior research has documented students’ struggles in conceiving of angle and angle measurement, which may stem from textbook and curriculum representations of angles as static. In this study, we examined grade 3-5 students’ mathematical thinking of angle during an educational robotics task implemented within a making space learning environment in a school setting (i.e., hybrid making space).MethodsOur analysis included 19 video recordings of six groups of students in grades 3-5.ResultsResults from this study demonstrate how students negotiated a shared understanding of angle through multiple epistemic tools (e.g., gestures, bodily actions, language) that were situated and contextualized within the task. This included developing a shared language, conceptualizing angle as a dynamic entity, and perceiving angle through directionality and degree measures.DiscussionWe contend that learning experiences within a hybrid making space provide young students with opportunities to engage in mathematics as a social phenomenon and human activity.
Association of apolipoprotein A1 levels with lumbar bone mineral density and β-CTX in osteoporotic fracture individuals: a cross-sectional investigation
Authors: Feng Li-long , Lu Ke , Li Chong , Xu Min-zhe , Ye Yao-wei , Yin Yi , Shan Hui-qiang 
Published: July 2024

BackgroundThe relationship between the levels of high-density lipoprotein (HDL) and bone mineral density (BMD) is controversial. Furthermore, the specific role of apolipoprotein A1 (APOA1), a primary HDL component, in regulating BMD remains unclear. This study aimed to elucidate the correlation between APOA1 levels and lumbar BMD in patients with osteoporotic fracture (OPF) for novel insights into potential therapeutic strategies against osteoporosis.MethodsThis study included 587 OPF patients enrolled at the Kunshan Hospital, Affiliated with Jiangsu University between January 2017 and July 2022. The patient’s serum APOA1 levels were determined, followed by the assessment of lumbar BMD and C-terminal telopeptide of type I collagen (β-CTX) as outcome variables. The association of APOA1 levels with lumbar BMD and β-CTX was assessed via Generalized Estimating Equations (GEE) and spline smoothing plot analyses. A generalized additive model (GAM) helped ascertain non-linear correlations. Moreover, a subgroup analysis was also conducted to validate the result’s stability.ResultsIt was observed that APOA1 levels were positively correlated with lumbar BMD (β = 0.07, 95% CI: 0.02 to 0.11, p = 0.0045), indicating that increased APOA1 levels were linked with enhanced lumbar BMD. Furthermore, APOA1 levels were negatively related to β-CTX (β = −0.19, 95% CI: −0.29 to −0.09, p = 0.0003), suggesting APOA1 might reduce osteolysis. In addition, these findings were robustly supported by subgroup and threshold effect analyses.ConclusionThis study indicated that increased APOA1 levels were correlated with enhanced lumbar BMD and decreased osteolysis in OPF patients. Therefore, APOA1 may inhibit osteoclast activity to prevent further deterioration in osteoporotic patients. However, further research I warranted to validate these conclusions and elucidate the underlying physiologies.
In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism
Authors: Ruan Dan-dan , Zou Jing , Liao Li-sheng , Ji Ming-dong , Wang Ruo-li , Zhang Jian-hui , Zhang Li , Gao Mei-zhu , Chen Qian , Yu Hong-ping , Wei Wen , Li Yun-fei , Li Hong , Lin Fan , Luo Jie-wei , Lin Xin-fu 
Published: July 2024

IntroductionWe previously reported that ATP1A3 c.823G&gt;C (p.Ala275Pro) mutant causes varying phenotypes of alternative hemiplegia of childhood and rapid-onset dystonia-parkinsonism in the same family. This study aims to investigate the function of ATP1A3 c.823G&gt;C (p.Ala275Pro) mutant at the cellular and zebrafish models.MethodsATP1A3 wild-type and mutant Hela cell lines were constructed, and ATP1A3 mRNA expression, ATP1A3 protein expression and localization, and Na+-K+-ATPase activity in each group of cells were detected. Additionally, we also constructed zebrafish models with ATP1A3 wild-type overexpression (WT) and p.Ala275Pro mutant overexpression (MUT). Subsequently, we detected the mRNA expression of dopamine signaling pathway-associated genes, Parkinson’s disease-associated genes, and apoptosisassociated genes in each group of zebrafish, and observed the growth, development, and movement behavior of zebrafish.ResultsCells carrying the p.Ala275Pro mutation exhibited lower levels of ATP1A3 mRNA, reduced ATP1A3 protein expression, and decreased Na+-K+-ATPase activity compared to wild-type cells. Immunofluorescence analysis revealed that ATP1A3 was primarily localized in the cytoplasm, but there was no significant difference in ATP1A3 protein localization before and after the mutation. In the zebrafish model, both WT and MUT groups showed lower brain and body length, dopamine neuron fluorescence intensity, escape ability, swimming distance, and average swimming speed compared to the control group. Moreover, overexpression of both wild-type and mutant ATP1A3 led to abnormal mRNA expression of genes associated with the dopamine signaling pathway and Parkinson’s disease in zebrafish, and significantly upregulated transcription levels of bad and caspase-3 in the apoptosis signaling pathway, while reducing the transcriptional level of bcl-2 and the bcl-2/bax ratio.ConclusionThis study reveals that the p.Ala275Pro mutant decreases ATP1A3 protein expression and Na+/K+-ATPase activity. Abnormal expression of either wild-type or mutant ATP1A3 genes impairs growth, development, and movement behavior in zebrafish.
Efficacy and survival outcome of allogeneic stem-cell transplantation in multiple myeloma: meta-analysis in the recent 10 years
Authors: Lin Si Yu , Lu Ke Jie , Zheng Xiao Na , Hou Jian , Liu Ting Ting 
Published: July 2024

IntroductionAllogeneic hematopoietic cell transplantation (alloHCT) possessed direct cytotoxicity and graft-versus-multiple myeloma effect (GvMM). Growing trials have shown survival benefits of performing alloHCT in both newly diagnosed and relapsed MM.MethodsWe aimed to provide a comprehensive analysis in the recent 10 years to verify the efficacy and survival outcome of alloHCT in MM patients. A total of 61 studies which provide data between 14/04/2013 and 14/04/2023 and a total of 15,294 data from MM patients who had undergone alloSCT were included in our study. The best response rates (CR, VGPR, PR) and survival outcomes (1-, 2-, 3-,5-, and 10-year OS, PFS, NRM) were assessed. We further conducted meta-analysis in the NDMM/frontline setting and RRMM/salvage setting independently.ResultsThe pooled estimate CR, VGPR, and PR rates were 0.45, 0.21, and 0.24, respectively. The pooled estimates of 1-, 2-, 3-, 5-, and 10-year OS were 0.69, 0.57, 0.45, 0.45, and 0.36, respectively; the pooled estimates of 1-, 2-, 3-, 5-, and 10-year PFS were 0.47, 0.35, 0.24, 0.25, and 0.28, respectively; and the pooled estimates of 1-, 2-, 3-, 5-, and 10-year NRM were 0.16, 0.21, 0.16, 0.20, and 0.15, respectively. In the NDMM/upfront setting, the pooled estimate CR rate was 0.54, and those for 5-year OS, PFS, and NRM were 0.69, 0.40, and 0.11, respectively. In a relapsed setting, the pooled estimate CR rate was 0.31, and those for 5-year OS, PFS, and NRM were 0.24, 0.10, and 0.15, respectively.DiscussionOur results showed constant OS, PFS, and NRM from the third year onwards till the 10th year, suggesting that alloSCT has sustained survival benefits. Good response rate and promising survival outcome were observed in the NDMM/ frontline setting.ConclusionAlthough comparing with other treatments, alloSCT had a lower response rate and poorer short-term survival outcome, long-term follow-up could reveal survival benefits of alloSCT in MM patients.
Activation of PERK/eIF2α/ATF4/CHOP branch of endoplasmic reticulum stress response and cooperation between HIF-1α and ATF4 promotes Daprodustat-induced vascular calcification
Authors: Tóth Andrea , Lente Gréta , Csiki Dávid Máté , Balogh Enikő , Szöőr Árpád , Nagy Béla , Jeney Viktória 
Published: July 2024

Introduction: Vascular calcification is accelerated in patients with chronic kidney disease (CKD) and increases the risk of cardiovascular events. CKD is frequently associated with anemia. Daprodustat (DPD) is a prolyl hydroxylase inhibitor for the treatment of CKD-associated anemia that enhances erythropoiesis through the activation of the hypoxia-inducible factor 1 (HIF-1) pathway. Studies showed that DPD promotes osteogenic differentiation of human aortic smooth muscle cells (HAoSMCs) and increases aorta calcification in mice with CKD. HIF-1 activation has been linked with endoplasmic reticulum (ER) stress; therefore, here we investigated the potential contribution of ER stress, particularly activating transcription factor 4 (ATF4), to the pro-calcification effect of DPD.Methods: Here, we used an adenine-induced CKD mouse model and HAoSMCs as an in vitro vascular calcification model to study the effect of DPD.Results: DPD treatment (15 mg/kg/day) corrects anemia but increases the expression of hypoxia (Glut1, VEGFA), ER stress (ATF4, CHOP, and GRP78), and osteo-/chondrogenic (Runx2, Sox9, BMP2, and Msx2) markers and accelerates aorta and kidney calcification in CKD mice. DPD activates the PERK/eIF2α/ATF4/CHOP pathway and promotes high phosphate-induced osteo-/chondrogenic differentiation of HAoSMCs. Inhibition of ER stress with 4-PBA or silencing of ATF4 attenuates HAoSMC calcification. DPD-induced ATF4 expression is abolished in the absence of HIF-1α; however, knockdown of ATF4 does not affect HIF-1α expression.Conclusion: We concluded that DPD induces ER stress in vitro and in vivo, in which ATF4 serves as a downstream effector of HIF-1 activation. Targeting ATF4 could be a potential therapeutic approach to attenuate the pro-calcific effect of DPD.
Mild-moderate alcohol consumption and diabetes are associated with liver fibrosis in patients with biopsy-proven MASLD
Authors: Huang Ang , Zou Cailun , Dai Zhe , Sun Ying , Wang Jing , Liu Shuhong , Han Lin , Chen Songhai , Liang Qingsheng , Wang Chunyan , Zhuang Yingjie , Dang Tong , Chang Binxia , Wang Yijin , Zou Zhengsheng 
Published: July 2024

BackgroundIt is unclear whether patients with metabolic dysfunction-associated steatotic liver disease (MASLD) are allowed variable low levels of alcohol. This study aimed to evaluate the effect of mild-moderate alcohol consumption on the biochemical and histological characteristics of patients with MASLD.MethodsAlcohol consumption was assessed in 713 patients with steatotic liver disease (SLD) who underwent liver biopsy. Non-drinking, mild-moderate drinking, and excessive drinking were defined as 0 g/day, 1-&lt;20 g/day, and &gt;20 g/day for women and 0 g/day, 1-&lt;30 g/day, and &gt;30 g/day for men, respectively. Liver biopsies were scored according to the NASH CRN system.ResultsA total of 713 participants (median age 39.0 years and 77.1% male) with biopsy-proven SLD were enrolled, including 239 nondrinkers, 269 mild-moderate drinkers and 205 excessive drinkers. Excessive drinking was associated with increased risks for lobular inflammation and liver fibrosis compared to nondrinkers and mild-moderate drinkers. Compared with non-drinkers, mild-moderate drinkers had significantly lower odds for steatosis (OR = 0.60, 95% CI = 0.38–0.93, p = 0.025), hepatocellular ballooning (OR = 0.52, 95% CI = 0.29–0.91, p = 0.020) and fibrosis (OR = 0.50, 95% CI = 0.31–0.81, p = 0.005). However, in non-excessive drinkers with type 2 diabetes mellitus (T2DM), there was no association between mild-moderate alcohol consumption and liver fibrosis (OR = 0.562, 95% CI = 0.207–1.530, p = 0.257).ConclusionsMild-moderate alcohol consumption might be protective against liver fibrosis in MASLD patients, which is modified by the presence of T2DM. However, further longitudinal studies are needed to determine the effect of ongoing alcohol consumption on disease severity.