bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor Yang Berhubungan Dengan Stres Kerja Pada Perawat Di RSUP Dr. Tadjuddin Chalid
Authors: Amaliyah Rizka , Sumiaty  , Rezky Aulia Yusuf  , Mansur Sididi  , Andi Sani  
Published: July 2024

Stres kerja terjadi dari ketidaksesuaian antara tuntutan dengan tekanan serta ketidaksesuaian pengetahuan dan kemampuan. Tenaga kesehatan terutama perawat, mempunyai resiko yang sangat tinggi terkena stres, karena perawat memiliki tugas dan tanggung jawab yang sangat tinggi terhadap keselamatan nyawa manusia. Terdapat beberapa faktor yang menyebabkan stres kerja yaitu faktor pekerjaan, faktor individu, faktor luar pekerjaan, dan faktor pendukung. Penelitian ini bertujuan untuk mengetahui faktor apa saja yang berhubungan dengan stres kerja pada perawat di RSUP Dr. Tadjuddin Chalid tahun 2022. Jenis penelitian ini adalah “observational analytic” dengan rancangan cross-sectional. Populasi dalam penelitian ini adalah semua perawat di RSUP Dr. Tadjuddin Chalid. Sampel diperoleh dengan metode accidental sampling, dengan jumlah sampel sebanyak 109 perawat. Pengolahan data menggunakan software SPSS dalam analisis univariat dan bivariat dengan uji korelasi chi-square. Hasil penelitian ini menunjukkan bahwa tidak ada hubungan antara faktor pekerjaan (tuntutan mental = 0.325, beban kerja = 0.984, konflik interpersonal = 0.733, kesempatan kerja = 0.202, dan shift kerja = 0.514), faktor luar pekerjaan (0.262), faktor individu (jenis kelamin = 1, umur = 0.690, status pernikahan = 0.350, dan masa kerja = 0.760), dan faktor pendukung (0.325).
Análisis conceptual de las instituciones y reglas fiscales: antecedentes y aplicación en la experiencia argentina
Authors: Martino Florencia M. 
Published: July 2024

En el presente artículo se aborda algunas ideas de destacados autores, como C. North[1], Mancur Olson y Elinor Ostrom. Estos académicos han analizado diversas temáticas como el desarrollo, la incidencia de las organizaciones y la modificación de las instituciones. El objetivo del presente artículo es conceptualizar que se entiende por organizaciones, y sus diferencias con las instituciones y explicar sus procesos de cambio, y como éstas determinan y afectan a las reglas fiscales vigentes desde la sanción de la Ley de Responsabilidad Fiscal sancionada en el año 2004.

[1] Premio Nobel de Economía en 1993 junto a Robert Fogel por la aplicación de técnicas cuantitativas para explicar los cambios económicos e institucionales, e incluirlos en la historia económica.
Ficciones deseadas, ficciones posibles:
Authors: Adler Jazmín 
Published: July 2024

Este artículo analiza determinadas obras artístico-tecnológicas exhibidas en los Estados Unidos en el contexto geopolítico de la década del sesenta, cuyos procesos de concepción y creación fueron posibles mediante la colaboración de artistas, ingenieros y científicos. El trabajo interdisciplinario entre los campos del arte, la ciencia y la tecnología adquirió un notable protagonismo en dicha coyuntura, signada por la carrera espacial iniciada con el lanzamiento de Sputnik en 1957, las fricciones entre los Estados Unidos y la Unión Soviética durante la Guerra Fría, la expansión de los medios de comunicación masiva y el crecimiento de grandes corporaciones, industrias y universidades consagradas al desarrollo científico-tecnológico. El trabajo analiza las modalidades de intercambio configuradas en cada caso entre las metodologías y herramientas de sus respectivos ámbitos, el rol desempeñado por artistas e ingenieros en la construcción de ficciones artístico-tecnológicas implicadas en el acto inventivo y las formas en que las experiencias de trabajo conjunto, en su vocación de especular con otros modos de producir conocimiento práctico y teórico, impulsaron la emergencia de nuevos campos del saber que desbordaron considerablemente los límites disciplinarios hasta entonces conocidos.
PRODUKTIVITAS KARYAWAN: PENGARUH KECAKAPAN KERJA, SUPERVISI TRANSFORMASIONAL DAN KENYAMANAN BEKERJA STUDI KASUS PT S&F GARMEN MANUFAKTUR
Authors: Oktaviani Dini , Suryani Ni Nyoman , Mitariani Ni Wayan Eka 
Published: July 2024

This research has a purpose to analyze the influence of proficiency, transformational supervision and enjoyment of work on PT performance. SF Garment Manufacturing. This research is kind ofof quantitative analysis and consists ofo 32 employees as the research population and sample. Data collection is carried out through questionnaire techniques using survey method. Data analysis uses SPSS 23 software which includes multiple linear regression test, classical test and hypothesis test, Based on the results of the analysis, research shows that proficiency has significantly give a positive influence both simultaneously and partially on the employee productivity. Transformational supervision also has significantly give a positive effect simultaneously and partially on employee productivity. Meanwhile, enjoyment of work simultaneously has significantly give a positive effect on PT performance. SF Garment Manufacturing. Research variables have coefficient determination 83,6% to influence the productivity of company’s employee. So, research in the future still needed to analyze other variable out from the research variables that already exist in this study.
Technology and research on the influence of liquid crystal cladding doped with magnetic Fe3O4 nanoparticles on light propagation in an optical taper sensor
Authors: Niewczas Michał , Stasiewicz Karol A. , Przybysz Natalia , Pakuła Anna , Paczesny Jan , Zbonikowski Rafał , Dziaduszek Jerzy , Kula Przemysław , Jaroszewicz Leszek R. 
Published: July 2024

The results obtained for new dual-cladding optical fiber tapers surrounded by liquid crystal (LC) doped with Fe3O4 nanoparticles in a specially developed glass cell are presented. The created structures are sensitive to changes in refractive index values in the surrounding medium caused by modifying external environment parameters. In this investigation, cells are filled with nematic LCs 6CHBT and with the same mixture doped with 0.1 wt% and 0.5 wt% of magnetic nanoparticles (Fe3O4 NPs). The taper is made on a standard single-mode telecommunication fiber, stretched out to a length of 20.0 ± 0.5 mm, and the diameter of the tapers is approximately 15.0 ± 0.3 μm, with a loss lower than 0.5 dB @ 1,550 nm. Measurements are carried out in a wide range covering the visible and infrared ranges in two setups: 1) without a magnetic field, with steering only by voltage and 2) with an applied magnetic field. The presented spectrum results are divided into two ranges according to the parameters of optical spectrum analyzers: 350–1,200 nm and 1,200–2,400 nm. For all investigations, a steering voltage is chosen from the range of 0 to 200 V, which allows for establishing the influence of dopants on transmitted power and time response at different arrangements. Due to the sensitivity of LCs to temperature changes, this paper focuses on measuring at room temperature the effect of the magnetic field on propagation in a fiber optic taper. The proposed solution demonstrates the technology for creating advanced components as a combination of fiber optic technology, LCs, and nanoparticles. The presented results show the possibility of creating new sensors of various external factors such as magnetic or electric fields in miniaturized dimensions.
Akkermansia muciniphila and Parabacteroides distasonis as prognostic markers for relapse in ulcerative colitis patients
Authors: Mendes-Frias Ana , Moreira Marta , Vieira Maria C. , Gaifem Joana , Costa Patrício , Lopes Luís , Silvestre Ricardo 
Published: July 2024

IntroductionUlcerative colitis is an inflammatory disorder characterized by chronic inflammation in the gastrointestinal tract, mainly in the colon and rectum. Although the precise etiology of ulcerative colitis remains unclear, recent research has underscored the significant role of the microbiome in its development and progression.MethodsThe aim of this study was to establish a relationship between the levels of specific gut bacterial species and disease relapse in ulcerative colitis. For this study, we recruited 105 ulcerative colitis patients in remission and collected clinical data, blood, and stool samples. Akkermansia muciniphila and Parabacteroides distasonis levels were quantified in the stool samples of ulcerative colitis patients. Binary logistic regression was applied to collected data to predict disease remission.ResultsThe median time in remission in this cohort was four years. A predictive model incorporating demographic information, clinical data, and the levels of Akkermansia muciniphila and Parabacteroides distasonis was developed to understand remission patterns.DiscussionOur findings revealed a negative correlation between the levels of these two microorganisms and the duration of remission. These findings highlight the importance of the gut microbiota in ulcerative colitis for disease prognosis and for personalized treatments based on microbiome interventions.
Anti-inflammatory effect of semaglutide: updated systematic review and meta-analysis
Authors: Masson Walter , Lobo Martín , Nogueira Juan Patricio , Rodriguez-Granillo Alfredo Matias , Barbagelata Leandro Ezequiel , Siniawski Daniel 
Published: July 2024

BackgroundThe anti-inflammatory effect could be one of the mechanisms by which semaglutide reduces cardiovascular risk in patients with type 2 diabetes mellitus (T2DM) and/or obesity. Determining the anti-inflammatory effect of semaglutide was the objective of this systematic review and meta-analysis.MethodsThis meta-analysis was performed according to the PRISMA guidelines. A literature search was performed to detect randomised clinical trials that have quantified the effect of semaglutide on C-reactive protein (CRP) levels compared to placebo or a control group (other glucose-lowering drugs). The primary outcome was CRP index (final CRP/basal CRP). A random-effects model was used.ResultsThirteen randomised clinical trials were considered eligible (n = 26,131). Overall, semaglutide therapy was associated with lower CRP index values compared to the placebo group (SMD −0.56; 95% CI −0.69 to −0.43, I2 92%) or the control group (SMD −0.45; 95% CI −0.68 to −0.23, I2 82%).Such an association was similarly observed when different treatment regimens (subcutaneous vs. oral) or different populations (patients with or without T2DM) were analysed. The sensitivity analysis showed that the results were robust.ConclusionThe present meta-analysis demonstrated that the use of semaglutide was associated with a reduction in inflammation irrespective of the population evaluated or the treatment regimen used. These findings would explain one of the mechanisms by which semaglutide reduces cardiovascular events.Systematic Review RegistrationPROSPERO [CRD42024500551].
High prevalence of ALPK3 premature terminating variants in Korean hypertrophic cardiomyopathy patients
Authors: Ryu Seung Woo , Jeong Won Chan , Hong Geu Ru , Cho Jung Sun , Lee Soo Yong , Kim Hyungseop , Jang Jeong Yoon , Lee Sun Hwa , Bae Dae-Hwan , Cho Jae Yeong , Kim Ji Hee , Kim Kyung-Hee , Son Jang Won , Han Beomman , Seo Go Hun , Lee Hane 
Published: July 2024

BackgroundThe alpha-protein kinase 3 (ALPK3) gene (OMIM: 617608) is associated with autosomal recessive familial hypertrophic cardiomyopathy-27 (CMH27, OMIM: 618052). Recently, several studies have shown that monoallelic premature terminating variants (PTVs) in ALPK3 are associated with adult-onset autosomal dominant hypertrophic cardiomyopathy (HCMP). However, these studies were performed on patient cohorts mainly from European Caucasian backgrounds.MethodsTo determine if this finding is replicated in the Korean HCMP cohort, we evaluated 2,366 Korean patients with non-syndromic HCMP using exome sequencing and compared the cohort dataset with three independent population databases.ResultsWe observed that monoallelic PTVs in ALPK3 were also significantly enriched in Korean patients with HCMP with an odds ratio score of 10–21.ConclusionsWe suggest that ALPK3 PTV carriers be considered a risk group for developing HCMP and be monitored for cardiomyopathies.
Diabetic microvascular complications and associated factors in patients with type 2 diabetes in Southern Ethiopia
Authors: Merid Fasika , Getahun Firdawek , Esubalew Habtamu , Gezahegn Tamirat 
Published: July 2024

BackgroundMicrovascular complications are long-term complications that affect small blood vessels, usually developed in diabetes, and are primary causes of end-stage renal disease, several painful neuropathies, and blindness. Thus, this study aimed to determine diabetic microvascular complications and factors associated with them among patients with type 2 diabetes.MethodsAn institution-based cross-sectional study was conducted among 378 type 2 diabetes patients. The presence of at least one diabetic microvascular complications diagnosed by physicians and found on the record was considered to have microvascular complications. The data was collected by reviewing the medical records of T2DM patients who were on follow-up from January 1, 2012, to December 31, 2021. The collected data was entered into EpiData version 3.1 and analyzed by Stata version 14. Bivariate and multivariable logistic regression were used to identify statistically significant risk factors for diabetic microvascular complications at p-value &lt; 0.05.ResultsPatients with type 2 diabetes mellitus had a prevalence of diabetic microvascular complications of 26.5% (95% CI: 22.0%, 30.9%). Diabetic neuropathy was the highest (13.2%), followed by diabetic nephropathy (12.4%), and diabetic retinopathy (6.4%). Increasing age, poor glycemic control, hypertension comorbidity, anemia, positive proteinuria, a longer duration of type 2 diabetes mellitus, and hypercholesterolemia were significantly associated factors with diabetic microvascular complications.ConclusionDiabetic microvascular complications were highly prevalent. Therefore, the study suggests that interventional strategies should be taken for poor glycemic control, hypertension comorbidity, anemia, positive proteinuria, and hypercholesterolemia to control the development of diabetic microvascular complications in patients with type 2 diabetes.
Efficacy of electro-acupuncture on pregnancy outcomes for women undergoing in vitro fertilization: study protocol for a pilot randomized controlled trial
Authors: Zheng Xiaoyan , Ji Ran , Li Chaoliang , Zhu Hao , Jiang Ziyi , Zhang Jingwen , Su Yang , Yu Siyi , Yu Zheng , Lv Xingyu , Liang Fanrong , Yang Jie 
Published: July 2024

IntroductionIn vitro fertilization (IVF) is a technology that assists couples experiencing infertility to conceive children. However, unsuccessful attempts can lead to significant physical and financial strain. Some individuals opt for electro-acupuncture (EA) during IVF, even though there is limited evidence regarding the efficacy of this practice. Thus, this pilot study aims to explore the effectiveness and safety of EA during IVF on pregnancy outcomes.Methods and analysisThis clinical trial is a parallel, randomized, sham-controlled study. It aims to include a total of 118 infertile women who intend to undergo IVF. The participants will be randomly divided into three groups in a 1:1:1 ratio: the EA + IVF group, the placebo electro-acupuncture (pEA) +IVF group, and the IVF control group. All of the patients will be required to use ovarian stimulation drugs, while those in the EA + IVF and pEA + IVF groups will receive acupuncture treatment at three sessions per week (every other day) until trigger day with a minimum five session. The primary outcome of this trial will focus on the clinical pregnancy rate (CPR). CPR is defined as the rate of achieving clinical pregnancy from the first fresh/frozen embryo transfer cycle with an ultrasound-confirmed gestational sac in the uterine cavity. The secondary outcomes will assess embryology data, biochemical pregnancy rate, early miscarriage rate, Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Pittsburgh Sleep Quality Index (PSQI), Fertile Quality of Life (FertiQoL), patient retention rate, treatment adherence, and safety outcomes.Ethics and disseminationEthics approval was obtained from the Ethics Committee of Sichuan Jinxin Xi’nan Women and Children Hospital (number 2021–007). The results will be disseminated through peer-reviewed publications. The participants gave informed consent to participate in the study before taking part in it.Clinical trial registrationhttps://www.chictr.org.cn, identifier ChiCTR2300074455.
The diagnostic and prognostic role of miR-146b-5p in differentiated thyroid carcinomas
Authors: Ferraz Carolina , Cunha Gustavo Bittar , de Oliveira Mariana Mazeu Barbosa , Tenório Lucas Ribeiro , Cury Adriano Namo , Padovani Rosália do Prado , Ward Laura Sterian 
Published: July 2024

IntroductionSamples classified as indeterminate correspond to 10-20% of cytologies obtained by fine needle biopsy of thyroid nodules, preventing an adequate distinction between benign and malignant lesions and leading to diagnostic thyroidectomies that often prove unnecessary, as most cases are benign. Furthermore, although the vast majority of patients with differentiated thyroid cancer (DTC) have such a good prognosis that active surveillance is permitted as an initial therapeutic option, relapses are not rare, and a non-negligible number of patients experience poor outcomes. MicroRNAs (miR) emerge as potential biomarkers capable of helping to define more precise management of patients in all these situations.MethodsAiming to investigate the clinical utility of miR-146b-5p in the diagnostic of thyroid nodules and evaluating its prognostic potential in a realworld setting, we studied 89 thyroid nodule samples, correlating miR-146b-5p expression with clinical tools such as the 8th edition from the American Joint Committee on Cancer (AJCC/UICC) and the American Thyroid Association Guideline Stratification Systems for the rate of recurrence (RR).ResultsmiR-146b-5p expression levels distinguished benign from malignant thyroid FNA samples (p&lt; 0.0001). For indeterminate nodules, overexpression of miR-146b-5p with a cut-off of 0.497 was able to diagnose malignancy with a 90% accuracy; specificity=87.5%; sensitivity=100%. An increased expression of miR-146b-5p was associated with greater RR (p=0.015). A cut-off of 2.21 identified cases with more vascular involvement (p=0.013) and a cut-off of 2.420 was associated with a more advanced TNM stage (p-value=0.047).DiscussionWe demonstrated that miR-146b5p expression in FNA samples is able to differentiate benign from malignant indeterminate nodules and is associated with an increased risk of recurrence and mortality, suggesting that this single miRNA may be a useful diagnostic and prognostic marker in the personalized management of DTC patients.
The multimorbidity association of metabolic syndrome and depression on type 2 diabetes: a general population cohort study in Southwest China
Authors: Cai Yulan , Zhou Shiyu , Fan Shangheng , Yang Yan , Tian Kunming , Luo Lei , Deng Renli , Dai Xingyu , Wang Yiying , Zhu Minglan , Liu Tao 
Published: July 2024

BackgroundMetabolic syndrome(MetS) and depression are independently associated with type 2 diabetes (T2DM) risk. However, little is known about the combined effect of MetS and depression on the risk of T2DM. The present study aims to prospectively explore the impact of MetS and depression on T2DM susceptibility among the Chinese general population.Methods6489 general population without T2DM adults in Southwest China were recruited from 2010 to 2012. Depression and MetS were prospectively assessed using a 9-item Patient Health Questionnaire(PHQ-9) and Guideline for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition) (CDS2020) during 2016–2020, respectively. Modified Poisson regression models were conducted to estimate relative risk(RR) and 95% confidence intervals (95%CI) for independent and combined associations of MetS and depression with an incidence of T2DM.ResultsDuring a median follow-up of 6.6 years, 678 cases of T2DM were documented. Individuals with MetS were 1.33 times more likely to develop T2DM than those without MetS. The corresponding RR(95%CI) for depression with no depression was 1.45(1.22–1.72). Notably, compared with no MetS or depression, the multivariate-adjusted RR for a combined effect of MetS and depression on the risk of T2DM was 2.11(1.39–3.22). Moreover, an increased risk of T2DM was more apparent in those ≥ 60 years, males, and overweight.ConclusionsIndividuals with multimorbidity of MetS and depression are at a higher risk of T2DM compared with those with no MetS or depression.
Metabolomic profile of secondary hyperparathyroidism in patients with chronic kidney disease stages 3–5 not receiving dialysis
Authors: Gan Lingling , Wang Lijun , Li Wanyi , Zhang Yamei , Xu Bei 
Published: July 2024

IntroductionSecondary hyperparathyroidism (SHPT) is a common and serious complication of chronic kidney disease (CKD). Elucidating the metabolic characteristics of SHPT may provide a new theoretical basis for its prevention and treatment. This study aimed to perform a metabolomic analysis of SHPT in patients with CKD stages 3–5 not receiving dialysis.MethodsA total of 76 patients with CKD, 85 patients with CKD-SHPT, and 67 healthy controls were enrolled in this study. CKD was diagnosed according to the criteria specified in the Kidney Disease Improving Global Outcomes 2012 guidelines. SHPT was diagnosed by experienced clinicians according to the Renal Disease Outcomes Quality Initiative Clinical Practice Guidelines. Serum renal function markers and the lipid profile were analyzed. Untargeted ultra performance liquid chromatography-tandem mass spectrometry was used to analyze the serum metabolites of patients with CKD and SHPT. Multivariate analysis of the data was performed using principal component analysis and partial least square discriminant analysis. Serum differential metabolites were identified and further characterized using databases. Pathway enrichment analysis was performed using the Kyoto Encyclopedia of Genes and Genomes database. Correlations between differential metabolites and clinical parameters were determined using the Spearman correlation.ResultsThe serum metabolomic profiles of patients with CKD with and without SHPT differed significantly. Differential metabolites were mainly enriched in the top four Kyoto Encyclopedia of Genes and Genomes pathways: phenylalanine, tyrosine, and tryptophan biosynthesis; sphingolipid metabolism; glycerophospholipid metabolism; and phenylalanine metabolism. In total, 31 differential metabolites were identified; of these, L-tryptophan and (R)-(+)-1-phenylethylamine were decreased, while other amino acids and their derivatives, uremia toxins, carnitine, and lipids, were increased significantly in patients with SHPT compared to those without. The 14 lipid metabolites were positively correlated with levels of Urea, serum creatinine, cystatin C, and triglycerides and negatively correlated with the estimated glomerular filtration rate and levels of total and high- and low-density lipoprotein cholesterol.DiscussionDisturbed amino acid and lipid metabolism were more apparent in patients with SHPT than in those without. This metabolomic profile of SHPT may provide a therapeutic foundation for its future clinical management.