bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost of overweight, obesity, and related complications in Switzerland 2021
Authors: Steinl David , Holzerny Pascale , Ruckdäschel Stephan , Fäh David , Pataky Zoltan , Peterli Ralph , Schultes Bernd , Landolt Susanne , Pollak Timo 
Published: July 2024

BackgroundThe prevalence of obesity has increased significantly in recent decades. Today, it is estimated that more than one-third of the world’s population has overweight or obesity, rendering it one of the most significant global health concerns. This article provides a current estimate of the direct costs associated with managing overweight and obesity, including treatment of related complications, among adolescents (≥15 years) and adults in Switzerland.MethodsPrevalence of overweight and obesity based on the BMI reported in the 2017 Swiss Health Survey was extrapolated to 2021. Systematic literature searches were performed to identify treatment costs and epidemiological data of obesity-related complications and costs were extrapolated to 2021. Costing methodology was based on available source data for individual related complications. Treatment costs for complications attributable to overweight and obesity were estimated by applying their population attributable fraction (PAF).ResultsMore than 3.1 million inhabitants of Switzerland aged ≥15 years met the criteria for overweight or obesity in 2021. The prevalence of overweight increase over the past decades from 30.4% in 1992 to 41.9% in 2017 while prevalence of obesity doubled from 5.4 to 11.3%. Overall, the total attributable costs of overweight and obesity caused by seven assessed obesity-related complications (asthma, coronary heart disease, depression, diabetes mellitus, hypertension, osteoarthritis, and stroke) are estimated at CHF 3657–5208 million with most of the costs (97–98%) caused by the assessed obesity-related complications. Only 2–3% of the total costs were attributable to the combined direct management of overweight and obesity by bariatric surgery (CHF 83 million), pharmacological therapy (CHF 26 million) and dietary counseling (CHF 18 million).ConclusionOverweight and obesity impose a significant cost impact on the Swiss healthcare system, accounting for 4.2–6.1% of total healthcare expenditures in 2021. Notably, direct treatment of overweight and obesity accounts for only 0.08–0.18% of the total healthcare expenditures. The analysis also revealed a significant lack of available health economic evidence, necessitating the use of assumptions and approximations in this estimation. This is noteworthy, as respective data would be available in healthcare systems but are either unpublished or inaccessible.
Facilitators and barriers of help-seeking for persons with dementia in Asia—findings from a qualitative study of informal caregivers
Authors: Jeyagurunathan Anitha , Yuan Qi , Samari Ellaisha , Zhang Yunjue , Goveas Richard , Ng Li Ling , Subramaniam Mythily 
Published: July 2024

Background and aimThe deterioration in cognition of persons with dementia (PWD) makes their caregivers key players in their help-seeking process. This study aimed to identify the facilitators and barriers of help-seeking for persons with dementia in Asia from the perspective of their informal caregivers.MethodsA qualitative methodology was adopted in the current study. Twenty-nine informal caregivers of PWD in Singapore were interviewed between April 2019 and December 2020. All interviews were audio-recorded and transcribed verbatim for the analysis.ResultsThe transcripts were analyzed using inductive thematic analysis. The results revealed four major themes with 12 sub-themes, including (1) Barriers to diagnosis-seeking (i.e., lack of knowledge and awareness of dementia, emotional denial, resistance from PWD, and delays in the healthcare system); (2) Facilitators of diagnosis-seeking (i.e., synergy between awareness of dementia and an active diagnosis-seeking intention and incidental diagnosis resulting from seeking treatment for comorbid conditions); (3) Barriers to treatment-seeking (i.e., challenges from PWD and disease, challenges faced by caregivers when seeking treatment for PWD, and challenges imposed by the COVID-19 pandemic); (4) Facilitators of treatment-seeking (i.e., caregivers’ capabilities of handling PWD, cooperation/compliance from PWD, and an integrated care plan for PWD).ConclusionThe findings highlight the importance of raising public awareness, enabling health professionals to tailor psychosocial interventions better, and improving community support through dementia awareness and education.
Public opinion on alcohol policies in Sri Lanka
Authors: Chandraratne Nadeeka K. , Negi Nalin Singh , Siyambalapitiya Hasini , De Seram Sampath , Selladurai Nidarshana , Pieris Karieshini , Rothenstein-Henry Rachel , Murukutla Nandita 
Published: July 2024

BackgroundAlcohol imposes a significant burden on health, social and economic systems in Sri Lanka. In the present economic crisis taxes on alcohol provides necessary revenue increases. Yet, the perception of the public on alcohol policies in Sri Lanka is not well explored.ObjectivesThis opinion survey was conducted with the aim to understand the public’s awareness on alcohol harm, alcohol industry influences, barriers and facilitators for implementing alcohol control policies in Sri Lanka, and the level of public support for alcohol policies, particularly taxes on alcohol products.MethodsA street intercept survey among 997 participants (with a ratio of 2:1 for males and females) selected through a cluster sampling method responded to an interviewer administered questionnaire. Bivariate and multivariate analyses were conducted to determine associations and a p &lt; 0.05 was considered significant.ResultsAmong the respondents, 36.1% have consumed alcohol at least once in their lifetime and 29.1% have consumed alcohol during the past 12 months with a significant gender difference (females - 2.8%; males- 43.4%; p &lt; 0.001). Significant proportions of both men (81.4%) and women (71.8%); p &lt; 0.017 agreed that policy measures to reduce alcohol consumption would benefit the government including a significant proportion (73.8%, p &lt; 0.008) of alcohol users. The vast majority −72.8%- agreed that increasing alcohol prices would help address the alcohol consumption problem in Sri Lanka. Moreover, only 30.8% of men and 44.3% of women agreed that the government’s alcohol laws are currently strong enough to protect people from alcohol harm. The regression analysis revealed that men are 2.43 times more in agreement with the statement that “policy measures aimed at reducing alcohol consumption can benefit the public” as compared to women. However, individuals aged 50–64 years are 40% less likely to agree with this statement as compared to 18–33 years.ConclusionThe majority of the public, including people who consume alcohol, are supportive of improving alcohol related policies, including taxes, and acknowledge negative impact of alcohol consumption on the country. This presents a clear opportunity for Sri Lanka to strengthen and enforce the alcohol related policies to protect and improve public health.
Insights into the spectrum of transtibial prosthetic socket design from expert clinicians and their digital records
Authors: Dickinson A. S. , Steer J. W. , Rossides C. , Diment L. E. , Mbithi F. M. , Bramley J. L. , Hannett D. , Blinova J. , Tankard Z. , Worsley P. R. 
Published: July 2024

BackgroundTranstibial prosthetic sockets are often grouped into patella tendon bearing (PTB) or total surface bearing (TSB) designs, but many variations in rectifications are used to apply these principles to an individual's personalised socket. Prosthetists currently have little objective evidence to assist them as they make design choices.AimsTo compare rectifications made by experienced prosthetists across a range of patient demographics and limb shapes to improve understanding of socket design strategies.Methodology163 residual limb surface scans and corresponding CAD/CAM sockets were analysed for 134 randomly selected individuals in a UK prosthetics service. This included 142 PTB and 21 TSB designs. The limb and socket scans were compared to determine the location and size of rectifications. Rectifications were compiled for PTB and TSB designs, and associations between different rectification sizes were assessed using a variety of methods including linear regression, kernel density estimation (KDE) and a Naïve Bayes (NB) classification.ResultsDifferences in design features were apparent between PTB and TSB sockets, notably for paratibial carves, gross volume reduction and distal end elongation. However, socket designs varied across a spectrum, with most showing a hybrid of the PTB and TSB principles. Pairwise correlations were observed between the size of some rectifications (e.g., paratibial carves; fibular head build and gross volume reduction). Conversely, the patellar tendon carve depth was not associated significantly with any other rectification, indicating its relative design insensitivity. The Naïve Bayes classifier produced design patterns consistent with expert clinician practice. For example, subtle local rectifications were associated with a large volume reduction (i.e., a TSB-like design), whereas more substantial local rectifications (i.e., a PTB-like design) were associated with a low volume reduction.Clinical implicationsThis study demonstrates how we might learn from design records to support education and enhance evidence-based socket design. The method could be used to predict design features for newly presenting patients, based on categorisations of their limb shape and other demographics, implemented alongside expert clinical judgement as smart CAD/CAM design templates.
Linking the impact of aspiration to host variables using the BOLUS framework: support from a rapid review
Authors: Palmer Phyllis M. , Padilla Aaron H. 
Published: July 2024

PurposeThe purpose of this rapid review was to identify the level of evidence for a previously proposed theoretical framework to assess risks associated with prandial aspiration using the host as a central theme.MethodsCovidence software was used to search two databases (PubMed and Web of Science). PEDro scale was utilized to determine the quality of individual studies. Data points were evaluated for level of support and determined to be either conclusive, suggestive, unclear, or not supportive. Within each component of the framework, data points were clustered to determine the level of evidence as strong, moderate, insufficient, or negative.ResultsThe rapid review process resulted in a limited number of publications investigating host variables impact on outcomes for patients with swallowing disorders. Overall, it yielded 937 articles, of which, upon review, 16 articles were selected for data extraction. There was a strong level of evidence to support that (a) as viscosity and density of aspirate increased, so did the likelihood of general medical complications, (b) poor oral care and oral health increase the risk of a pulmonary or general medical complication, and (c) the presence of oropharyngeal or laryngeal tubes increases the risk of a pulmonary consequence. There was moderate evidence to support the impact of amount and frequency of aspiration on outcomes. There was insufficient evidence to determine relationships for all other aspects of the BOLUS framework.ConclusionAdditional evidence to support the BOLUS framework was obtained; however, the number of studies was limited. A more thorough review such as a systematic review should be employed.
Quality-of-life survey of pancreatic cancer patients: a comparison between general public and physicians
Authors: Sasahara Yuriko , Takumoto Yuki , Watanabe Kaname , Takeda Hiroyuki , Umemoto Kumiko , Sunakawa Yu , Suzuki Naoki , Yoshioka Takashi , Kobayashi Satoshi , Ueno Makoto , Nakamura Sho , Akazawa Manabu , Narimatsu Hiroto 
Published: July 2024

BackgroundQuality-of-life (QOL) is important for cancer patients with poor prognosis. However, conducting a QOL survey with patients is difficult. Therefore, we conducted a QOL survey with physicians. Specifically, this study aimed to clarify how physicians assess QOL in patients with pancreatic cancer by conducting a survey and comparing the results between physicians and the general public.MethodsA survey was conducted by interviewing physicians administering chemotherapy to patients for recurrent/metastatic pancreatic cancer. This method is similar to that of the QOL survey conducted among the general public. Responses were evaluated using the composite time trade-off (cTTO) and the visual analog scale (VAS) for 11 pancreatic cancer status scenarios (survey scenarios). These scenarios consisted of patients’ health states as well as the types and grades of adverse events (AEs). Health status was classified into two categories: Stable disease (SD) and Progressive disease (PD). In addition, we conducted a survey using the EuroQol 5 Dimensions 5-Level (EQ-5D-5l) as reference values.ResultsTwenty physicians responded to the survey. SD had the highest mean QOL value for both assessment methods (Physicians: 0.78, General public: 0.63), whereas PD had the lowest mean QOL value (Physicians: 0.15, General public: −0.12). The physicians assigned higher QOL values on both the VAS and cTTO than the general public did in all survey scenarios.ConclusionsThe QOL values obtained from physicians were consistent with the degree of status in any assessment scenarios. Based on the differences in the QOL survey results between physicians and the general public, physicians tended to assign higher QOL values than the general public in cTTO and VAS assessments.
Enhancing Buoyant force learning through a visuo-haptic environment: a case study
Authors: Neri Luis , Noguez Julieta , Escobar-Castillejos David , Robledo-Rella Víctor , García-Castelán Rosa María Guadalupe , Gonzalez-Nucamendi Andres , Magana Alejandra J. , Benes Bedrich 
Published: July 2024

Introduction: This study aimed to develop, implement, and test a visuo-haptic simulator designed to explore the buoyancy phenomenon for freshman engineering students enrolled in physics courses. The primary goal was to enhance students’ understanding of physical concepts through an immersive learning tool.Methods: The visuo-haptic simulator was created using the VIS-HAPT methodology, which provides high-quality visualization and reduces development time. A total of 182 undergraduate students were randomly assigned to either an experimental group that used the simulator or a control group that received an equivalent learning experience in terms of duration and content. Data were collected through pre- and post-tests and an exit-perception questionnaire.Results: Data analysis revealed that the experimental group achieved higher learning gains than the control group (p = 0.079). Additionally, students in the experimental group expressed strong enthusiasm for the simulator, noting its positive impact on their understanding of physical concepts. The VIS-HAPT methodology also reduced the average development time compared to similar visuo-haptic simulators.Discussion: The results demonstrate the efficacy of the buoyancy visuo-haptic simulator in improving students’ learning experiences and validate the utility of the VIS-HAPT method for creating immersive educational tools in physics.
Relationship of selected conditioning parameters and sport performance indicators in karate
Authors: Nema Kristina , Ruzbarsky Pavel , Rydzik Łukasz , Peric Tomas 
Published: July 2024

IntroductionThe variables of aerobic performance and aerobic capacity are of significant importance in maintaining intensity during a fight and also contribute to faster recovery between rounds in sports fighting in karate. Anaerobic performance is crucial for the execution of the techniques during high-intensity offensive or defensive actions that determine the outcome of a fight. The objective of this study was to assess the relationship between selected performance indicators of aerobic and anaerobic capacity to sports performance in karate.MethodsThe study included six male karate athletes (age 28 ± 3 years, body mass 85.10 kg; height 185.5 cm), medalists from European and World championship, events in senior categories. The selection criteria included training experience and sports level. The Karate specific aerobic test (KSAT) was use in conjunction with heart rate monitoring and changes in blood lactate levels to diagnose special aerobic endurance parameters. To determine the level of anaerobic performance the Wingate test were choosed. Technical and tactical indicators (efficiency, effectiveness and activeness of the attack) were used to assess the sports skill level during competition.ResultsBased on the Spearman correlation coefficient results demonstrated statistically significant differences (rs = −0.81) with large effect size index between efficiency of the attack and average heart rate achieved in the test KSAT. Additionally statistically significant differences (rs = 0.81) with large effect size were demonstrated between the fatigue index and efficiency of the attack Furthermore, the selected indicators of special aerobic endurance parameters and anaerobic performance demonstrated a high degree of predictive validity in relation to the efficiency (rp = 0.960) and activity (rp = 0.927) of attacks.ConclusionThe high level of predictive validity confirmed the importance of a high level of anaerobic conditions for performance in karate. The low values of the average heart rate in relation to the efficiency of the attack confirm the high performance level of karate athletes in relation to special aerobic performance parameters. It was found that the effectiveness of the attack had no relation to the monitored parameters.
Efficacy of axillary dead space closure after mastectomy, axillary clearance and prosthetic reconstruction: a single-center preliminary experience
Authors: Lisa Andrea , Bozzo Giulia , Vinci Valeriano , Klinger Francesco Maria , Errico Valentina , Tinterri Corrado , Klinger Marco Ettore Attilio , Testori Alberto 
Published: July 2024

BackgroundPostoperative seroma is most frequent after mastectomy (ME) in combination with axillary lymph node dissection (ALND), and its reported incidence varies from 15.5% up to 90%. Seromas can be responsible for discomfort, infections and can lead to reconstruction failure. Therefore, many ways of seroma prevention have been studied, although from a recent overview it has become clear that no single method is reliably successful. Mechanical closure of the dead space, however, was consistently found to be significantly effective. The aim of our study is to evaluate if quilting of the axilla, in patients undergoing ME, immediate prosthetic breast reconstruction and ALND reduces the duration of drain maintenance, the incidence of seromas that require aspiration (clinically significant seromas, CSS) and reconstruction failure rate.Materials and methodsIn our study population we analyzed a total of 81 patients divided into two groups: 27 consecutive patients undergoing mastectomy, axillary lymph node dissection (ALND), breast reconstruction and quilting of the axilla. We subsequently randomly picked up a double number of patients (54) undergoing the same oncological and reconstructive procedures without undergoing axillary quilting, matched for clinical characteristics in order to analyze efficacy of the procedure while reducing any bias. Our observational retrospective data was collected from October 2016 to July 2020 in one single high-volume center. Our median follow-up time was of 40.6 months.ResultsIn the case group we observed a reduced time of drain maintenance: 16 vs. 20 days observed in the non-quilted group (p &lt; 0.05). Incidence of seromas that required aspiration was 11% in the control group, while 3,7% in the case group. In addition to that, we observed 6 cases of implant removal in the control group, while in the quilted group we only observed a single case.ConclusionPrevious literature and our results confirm that quilting of the axilla with flap fixation significantly decreases time of drain maintenance, allowing the earlier removal of the drains as well as decreasing the incidence of seroma, its eventual associated complications and related social costs. Moreover, our work suggests how quilting sutures decrease the incidence of seroma in patients undergoing immediate reconstruction, probably reducing the risk for implant removal.
In vitro impact of ethanolic extract of Bryonia laciniosa seed on Gir bull spermatozoa: a comprehensive evaluation through transcriptome profiling
Authors: Italiya Jignesh , Panchal Ketankumar J. , Jakhesara Subhash J. , Joshi Chaitanya G. , Koringa Prakash G. 
Published: July 2024

Aim/objectivesThis study examines the in vitro impact of an ethanolic extract derived from Bryonia laciniosa seeds on the Gir bull (Bos indicus) spermatozoa. The objective is to thoroughly assess the effects of the seed extract on the physiological parameters of bull spermatozoa, followed by evaluating its effects on X and Y-bearing spermatozoa and its impact on gene expression through transcriptome profiling.Material methodFor this study, one Gir bull was selected, and 12 ejaculates were collected at one-week time intervals. Sperm cells were isolated from each ejaculate and incubated with varying concentrations of the ethanolic extract. The physiological parameters of the spermatozoa were assessed using Computer Assisted Semen Analysis (CASA) and compared with control groups to evaluate the extract’s effects on sperm quality and motility.Results and discussionAt a concentration of 18 mg/mL B. laciniosa extract, we noticed a statistically significant 16.4% increase in sperm motility (p = 0.0065). In order to understand the specific effect on X and Y-bearing spermatozoa, motile and non-motile sperm separated by glass wool column method and further evaluated for quantification of X and Y-bearing sperm in all samples by ddPCR. To understand the effect of B. laciniosa extract on spermatozoa at the molecular level, whole transcriptome profiling was carried out using Illumina MiSeq. Transcriptome profiling revealed 81 genes that were expressed differently between the group treated with the extract and the control group. The current investigation revealed an increase in the expression of TLX1, CRYGB, KLF13, and ZAR1 transcripts, which play a role in embryonic development. In addition, several genes have been identified that are involved in sperm motility, such GSK3B, LAPRS, MAPK1, CAMK2B, and AQP7. The findings exhibited the therapeutic effectiveness of B. laciniosa seeds in augmenting fertility through a synergistic blend of activities, including enhanced sperm motility and positive influence on embryogenesis.