bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of return-to-work interventions that incorporate work-focused problem-solving skills for workers with sickness absences related to mental disorders: a systematic literature review
Authors: Dewa Carolyn S , Loong Desmond , Bonato Sarah , Joosen Margot C W 
Published: June 2015

ObjectivesThis paper reviews the current state of the published peer-reviewed literature related to return-to-work (RTW) interventions that incorporate work-related problem-solving skills for workers with sickness absences related to mental disorders. It addresses the question: What is the evidence for the effectiveness of these RTW interventions?DesignUsing a multiphase screening process, this systematic literature review was based on publically available peer-reviewed studies. Five electronic databases were searched: (1)Medline Current, (2)Medline In-process, (3)PsycINFO, (4)Econlitand (5)Web of Science.SettingThe focus was on RTW interventions for workers with medically certified sickness absences related to mental disorders.ParticipantsWorkers with medically certified sickness absences related to mental disorders.InterventionsRTW intervention included work-focused problem-solving skills.Primary and secondary outcome measuresRTW rates and length of sickness absences.ResultsThere were 4709 unique citations identified. Of these, eight articles representing a total of six studies were included in the review. In terms of bias avoidance, two of the six studies were rated asexcellent, two asgoodand two asweak. Five studies were from the Netherlands; one was from Norway. There was variability among the studies with regard to RTW findings. Two of three studies reported significant differences in RTW rates between the intervention and control groups. One of six studies observed a significant difference in sickness absence duration between intervention and control groups.ConclusionsThere is limited evidence that combinations of interventions that include work-related problem-solving skills are effective in RTW outcomes. The evidence could be strengthened if future studies included more detailed examinations of intervention adherence and changes in problem-solving skills. Future studies should also examine the long-term effects of problem-solving skills on sickness absence recurrence and work productivity.
Cadmium exposure and incidence of heart failure and atrial fibrillation: a population-based prospective cohort study
Authors: Borné Yan , Barregard Lars , Persson Margaretha , Hedblad Bo , Fagerberg Björn , Engström Gunnar 
Published: June 2015

ObjectivesCadmium is a non-essential toxic metal with multiple adverse health effects. Cadmium has been shown to be associated with cardiovascular diseases, but few studies have investigated heart failure (HF) and none of them reported atrial fibrillation (AF). We examined whether cadmium exposure is associated with incidence of HF or AF.DesignA prospective, observational cohort study with a 17-year follow-up.SettingThe city of Malmö, Sweden.ParticipantsBlood cadmium levels were measured in 4378 participants without a history of HF or AF (aged 46–67 years, 60% women), who participated in the Malmö Diet and Cancer (MDC) study during 1992–1994.Primary and secondary outcome measuresIncidence of HF and AF were identified from the Swedish hospital discharge register.Results143 participants (53% men) were diagnosed with new-onset HF and 385 individuals (52% men) were diagnosed with new-onset AF during follow-up for 17 years. Blood cadmium in the sex-specific 4th quartile of the distribution was significantly associated with incidence of HF. The (HR, 4th vs 1st quartile) was 2.64 (95% CI 1.60 to 4.36), adjusted for age, and 1.95 (1.02 to 3.71) after adjustment also for conventional risk factors and biomarkers. The blood cadmium level was not significantly associated with risk of incident AF.ConclusionsBlood cadmium levels in the 4th quartile were associated with increased incidence of HF in this cohort with comparatively low exposure to cadmium. Incidence of AF was not associated with cadmium.
Transitioning patients with inflammatory bowel disease (IBD) from adolescent to adult services: a systematic review
Authors: Clarke Tilean , Lusher Joanne 
Published: June 2015

Approximately a quarter of patients with inflammatory bowel disease (IBD) are diagnosed before 20 years of age, presenting with more extensive distribution and severity of disease than adult onset. The purpose of this review was to determine facilitators of, and barriers to, successful transition of patients with IBD from adolescent to adult services. A systematic review of IBD transition research was conducted in March 2014 searching PubMed, MEDLINE, PsycINFO, Web of Science and the Cochrane Database of Systematic Reviews databases. A hand search of reference lists and narrative reviews was carried out to maximise the potential for retrieving all relevant manuscripts. Primary studies written in English of full-length peer-reviewed journal articles that investigated transition of paediatric patients with IBD to adult services were included. Studies were excluded if the primary focus was not IBD. The search produced 283 potentially relevant studies. After removing duplicates and screening for suitability, six met our inclusion criteria. Barriers to transition included system inadequacies and a lack of resources, clinical time and training. Successful transition involved joint medical visits, structured transition services, improved communication between paediatric and adult services and improved education for patients and staff. If the transition process for adolescents suffering with IBD is to improve then it is vital that more research is conducted to better our understanding of ways in which we can ensure that defined protocols are in place for a smooth transition for every adolescent, leading to improved standards and minimal disruption to care.
ASSESSING SOME IMPORTANT FACTORS TO REDUCE OBSTACLES IN PRODUCT INNOVATION
Authors: NAGANO MARCELO SEIDO , STEFANOVITZ JULIANO PAVANELLI , GUIMARAES TOR 
Published: June 2015

The need for effective and efficient Product Innovation (PI) is a great challenge for organisations in today’s hypercompetitive global markets. Many research studies addressed problems/obstacles to successful PI from various perspectives. Many other studies proposed factors to help companies mitigate such problems. Here, the primary objective is to propose an integrated model, to empirically test this model, and get insights about which factors, if managed appropriately, will help reduce the obstacles to PI in practice. A questionnaire was developed, pilot tested, and used to collect data from 47 PI managers. The results support the theoretical importance of a formal PI process, characteristics of the company environment, and the availability of specific resources as important factors to reduce obstacles to company PI. Based on the results recommendations are made to practitioners and researchers in this important area.
Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer
Authors: Du Juan , Cieslak John A. , Welsh Jessemae L. , Sibenaller Zita A. , Allen Bryan G. , Wagner Brett A. , Kalen Amanda L. , Doskey Claire M. , Strother Robert K. , Button Anna M. , Mott Sarah L. , Smith Brian , Tsai Susan , Mezhir James , Goswami Prabhat C. , Spitz Douglas R. , Buettner Garry R. , Cullen Joseph J. 
Published: June 2015

Abstract
The toxicity of pharmacologic ascorbate is mediated by the generation of H2O2 via the oxidation of ascorbate. Because pancreatic cancer cells are sensitive to H2O2 generated by ascorbate, they would also be expected to become sensitized to agents that increase oxidative damage such as ionizing radiation. The current study demonstrates that pharmacologic ascorbate enhances the cytotoxic effects of ionizing radiation as seen by decreased cell viability and clonogenic survival in all pancreatic cancer cell lines examined, but not in nontumorigenic pancreatic ductal epithelial cells. Ascorbate radiosensitization was associated with an increase in oxidative stress–induced DNA damage, which was reversed by catalase. In mice with established heterotopic and orthotopic pancreatic tumor xenografts, pharmacologic ascorbate combined with ionizing radiation decreased tumor growth and increased survival, without damaging the gastrointestinal tract or increasing systemic changes in parameters indicative of oxidative stress. Our results demonstrate the potential clinical utility of pharmacologic ascorbate as a radiosensitizer in the treatment of pancreatic cancer. Cancer Res; 75(16); 3314–26. ©2015 AACR.
Long-Term Effects of Ganglionated Plexi Ablation on Electrophysiological Characteristics and Neuron Remodeling in Target Atrial Tissues in a Canine Model
Authors: Wang Ximin , Zhang Ming , Zhang Yujiao , Xie Xinxing , Wang Weizong , Li Zhan , Gao Mei , Wang Zhongsu , Hou Yinglong 
Published: June 2015

Background—
The long-term effects of ganglionated plexi ablation on electrophysiological characteristics and neuron remodeling in target atrial tissues remain unclear.

Methods and Results—

Dogs in group 1 (control, n=8) were not subjected to ganglionated plexi ablation and observed for 1 month, and dogs in groups 2 to 4 (ablation groups, n=8 each) underwent ablation of the right-sided ganglionated plexi and observed for 1, 6, and 12 months, respectively. Atrial electrophysiological characteristics were examined before ablation, immediately and continuously after ablation. Target atrial tissues were subjected to immunohistochemical staining and Western blot analysis. Atrial effective refractory period was significantly prolonged immediately after ablation (
P
<0.001), and persisted for 1 month (
P
<0.05). Nerve densities decreased 1 month after ablation (
P
<0.001). These parameters reverted to preablation levels after 6 and 12 months. In the ablation groups, atrial fibrillation was induced in 5 of 8 dogs after 1 month and in all animals after 6 and 12 months. Atrial fibrillation was not observed in the control group and in the experimental groups immediately after ablation. Moreover, the expression of the growth-associated protein 43 was upregulated after ablation.

Conclusions—
Ganglionated plexi ablation effectively prolonged atrial effective refractory period for a short period, but the long-term effects on atrial effective refractory period and the suppression of atrial fibrillation induction were not persistent. Targeted atrial neuron remodeling may be an important mechanism underlying the observed electrophysiological changes.
Magnetic Resonance Angiography Detection of Abnormal Carotid Artery Plaque in Patients With Cryptogenic Stroke
Authors: Gupta Ajay , Gialdini Gino , Lerario Michael P. , Baradaran Hediyeh , Giambrone Ashley , Navi Babak B. , Marshall Randolph S. , Iadecola Costantino , Kamel Hooman 
Published: June 2015

Background

Magnetic resonance imaging of carotid plaque can aid in stroke risk stratification in patients with carotid stenosis. However, the prevalence of complicated carotid plaque in patients with cryptogenic stroke is uncertain, especially as assessed by plaque imaging techniques routinely included in acute stroke magnetic resonance imaging protocols. We assessed whether the magnetic resonance angiography–defined presence of intraplaque high‐intensity signal (
IHIS
), a marker of intraplaque hemorrhage, is associated with ipsilateral cryptogenic stroke.

Methods and Results

Cryptogenic stroke patients with magnetic resonance imaging evidence of unilateral anterior circulation infarction and without hemodynamically significant (≥50%) stenosis of the cervical carotid artery were identified from a prospective stroke registry at a tertiary‐care hospital. High‐risk plaque was assessed by evaluating for
IHIS
on routine magnetic resonance angiography source images using a validated technique. To compare the presence of
IHIS
on the ipsilateral versus contralateral side within individual patients, we used McNemar's test for correlated proportions. A total of 54 carotid arteries in 27 unique patients were included. A total of 6 patients (22.2%) had
IHIS
‐positive nonstenosing carotid plaque ipsilateral to the side of ischemic stroke compared to 0 patients who had
IHIS
‐positive carotid plaques contralateral to the side of stroke (
P
=0.01). Stroke severity measures, diagnostic evaluations, and prevalence of vascular risk factors were not different between the
IHIS
‐positive and
IHIS
‐negative groups.

Conclusions
Our findings suggest that a proportion of strokes classified as cryptogenic may be mechanistically related to complicated, nonhemodynamically significant cervical carotid artery plaque that can easily be detected by routine magnetic resonance imaging/magnetic resonance angiography acute stroke protocols.
Neurocognitive status is associated with all-cause mortality among psychiatric, high-risk liver transplant candidates and recipients
Authors: Madan A , Borckardt JJ , Balliet WE , Barth KS , Delustro LM , Malcolm RM , Koch D , Willner I , Baliga P , Reuben A 
Published: June 2015

Objective Judicious selection of potential liver transplant candidates and close monitoring of progress are essential to successful outcomes. Pretransplant psychosocial evaluations are the norm, but the relationship between psychosocial (and neurocognitive status) and longer term medical outcomes is understudied. This exploratory study sought to examine the relationship between objective measures of pretransplant psychosocial and neurocognitive status and service utilization, transplant status, and all-cause mortality. Methods This retrospective chart review examined outcomes among 108 psychiatric, high-risk liver transplant candidates up to four years following initial evaluation. Predictor variables of outcomes included demographic, medical, neurocognitive, psychological, and mental health treatment variables. Results Transplant status and neurocognitive functioning were independently associated with all-cause mortality. None of the other variables were associated with outcomes. Conclusions Better neurocognitive functioning in high-risk liver transplant candidates may allow for greater involvement in medical care and/or compliance with treatment recommendations. More aggressive assessment and management of neurocognitive dysfunction may improve outcomes. Objective measures identified significant psychopathology typical of liver transplant candidates but were not associated with outcomes; engagement in specialized mental health care may have attenuated this relationship. Further study is needed to better understand the relationship between psychosocial functioning and outcomes.
A Qualitative Investigation of Return to Sport After Arthroscopic Bankart Repair
Authors: Tjong Vehniah K. , Devitt Brian M. , Murnaghan M. Lucas , Ogilvie-Harris Darrell J. , Theodoropoulos John S. 
Published: June 2015

Background: Arthroscopic shoulder stabilization is known to have excellent functional results, but many patients do not return to their preinjury level of sport, with return to play rates reported between 48% and 100% despite good outcome scores. Purpose: To understand specific subjective psychosocial factors influencing a patient’s decision to return to sport after arthroscopic shoulder stabilization. Study Design: Case series; Level of evidence, 4. Methods: Semistructured qualitative interviews were conducted with patients aged 18 to 40 years who had undergone primary arthroscopic shoulder stabilization and had a minimum 2-year follow-up. All patients participated in sport before surgery without any further revision operations or shoulder injuries. Qualitative data analysis was performed in accordance with the Strauss and Corbin theory to derive codes, categories, and themes. Preinjury and current sport participation was defined by type, level of competition, and the Brophy/Marx shoulder activity score. Patient-reported pain and shoulder function were also obtained. Results: A total of 25 patients were interviewed, revealing that fear of reinjury, shifts in priority, mood, social support, and self-motivation were found to greatly influence the decision to return to sport both in patients who had and had not returned to their preinjury level of play. Patients also described fear of sporting incompetence, self-awareness issues, recommendations from physical therapists, and degree of confidence as less common considerations affecting their return to sport. Conclusion: In spite of excellent functional outcomes, extrinsic and intrinsic factors such as competing interests, kinesiophobia, age, and internal stressors and motivators can have a major effect on a patient’s decision to return to sport after arthroscopic shoulder stabilization. The qualitative methods used in this study provide a unique patient-derived perspective into postoperative recovery and highlight the necessity to recognize and address subjective and psychosocial factors rather than objective functional outcome scores alone as contributing to a patient’s decision to return to play.
Availability of Advanced Breast Imaging at Screening Facilities Serving Vulnerable Populations
Authors: Lee Christoph I , Bogart Andy , Germino Jessica C , Goldman L Elizabeth , Hubbard Rebecca A , Haas Jennifer S , Hill Deirdre A , Tosteson Anna NA , Alford-Teaster Jennifer A , DeMartini Wendy B , Lehman Constance D , Onega Tracy L 
Published: June 2015

Objective Among vulnerable women, unequal access to advanced breast imaging modalities beyond screening mammography may lead to delays in cancer diagnosis and unfavourable outcomes. We aimed to compare on-site availability of advanced breast imaging services (ultrasound, magnetic resonance imaging [MRI], and image-guided biopsy) between imaging facilities serving vulnerable patient populations and those serving non-vulnerable populations. Setting 73 imaging facilities across five Breast Cancer Surveillance Consortium regional registries in the United States during 2011 and 2012. Methods We examined facility and patient characteristics across a large, national sample of imaging facilities and patients served. We characterized facilities as serving vulnerable populations based on the proportion of mammograms performed on women with lower educational attainment, lower median income, racial/ethnic minority status, and rural residence. We performed multivariable logistic regression to determine relative risks of on-site availability of advanced imaging at facilities serving vulnerable women versus facilities serving non-vulnerable women. Results Facilities serving vulnerable populations were as likely (Relative risk [RR] for MRI = 0.71, 95% Confidence Interval [CI] 0.42, 1.19; RR for MRI-guided biopsy = 1.07 [0.61, 1.90]; RR for stereotactic biopsy = 1.18 [0.75, 1.85]) or more likely (RR for ultrasound = 1.38 [95% CI 1.09, 1.74]; RR for ultrasound-guided biopsy = 1.67 [1.30, 2.14]) to offer advanced breast imaging services as those serving non-vulnerable populations. Conclusions Advanced breast imaging services are physically available on-site for vulnerable women in the United States, but it is unknown whether factors such as insurance coverage or out-of-pocket costs might limit their use.
Recovery From Schizophrenia in Community-Based Psychosocial Rehabilitation Settings
Authors: Lim Caroline , Barrio Concepción , Hernandez Mercedes , Barragán Armando , Brekke John S. 
Published: June 2015

Objective: We assessed the rate of recovery from schizophrenia in community-based psychosocial rehabilitation and whether psychosocial attributes predicted the achievement of recovery beyond demographic and clinical characteristics. Methods: We used data from 246 individuals with schizophrenia spectrum disorder collected at baseline and at 6 and 12 months after admission to psychosocial rehabilitation. Results: The proportion of participants who showed recovery during either 6-month period and the full 1-year period was 19.86% and 7.53%, respectively. Although predictors of recovery for the 1-year period could not be reliably estimated due to its low rate, higher levels of intrinsic motivation and more positive family relationships at baseline predicted recovery for either 6-month period after controlling for initial functioning capacity. Conclusions: One in five individuals with schizophrenia who engage in intensive community-based psychosocial rehabilitation can achieve periods of recovery during treatment. Psychosocial attributes at the start of treatment are important contributors to subsequent recovery.
Social media used as a health intervention in adolescent health: A systematic review of the literature
Authors: Shaw Julie M , Mitchell Creina A , Welch Anthony J , Williamson Moira J 
Published: June 2015

Objective Adolescents are known to be high users of social media, and social media is beginning to be used in health care. The primary objective of this review was to determine the current state of play on the use of social media as a health intervention in addressing the health of adolescents. Methods Six databases were searched: CINAHL, Medline, Scopus, ProQuest, Psych Info and Science Direct, from 2000–2013. The review process followed PRISMA guidelines with quality assessments of the selected articles undertaken. Results Three studies used social media as a health intervention in adolescent health. Facebook was the social media of choice. The way this social media tool was incorporated as the intervention varied. None of the social media interventions had a significant or sustained impact on the primary outcomes of the studies reviewed. Measures of social media process were limited and lacked meaning. Conclusions The selected papers provided insight into the beginning phase of using social media as a health intervention to address adolescent health. The review highlights three important areas for consideration when undertaking research on the use of social media as a health intervention for adolescents: the newness of using social media as a health intervention, the importance of the use of rigorous methodological processes when using social media as a health intervention, and the need to develop further knowledge on adolescents’ use of social media, in particular their hidden world of social media.