bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Depth of Sedation With Ketamine Alone Versus Ketamine With Midazolam in Pediatric Fracture Reduction
Authors: Wells Kimberly , Calleo Vincent 
Published: August 2024

Objectives
Pediatric patients with extremity fractures often require sedation for fracture reduction in the pediatric emergency department (PED). Although orthopedic literature suggests combination sedation regimens may be more effective for fracture reduction, some pediatric literature suggests adverse events are more frequent. The primary objective of this study is to determine the comparable depth of sedation and incidence of adverse events when intravenous ketamine is used alone versus with midazolam for pediatric procedural sedation and orthopedic fracture reduction.

Methods
This is a retrospective cohort study of pediatric patients 2–18 years old who underwent sedation for fracture reduction in the PED at a single level 1 trauma center over a 2-year period. Medical records were reviewed, and occurrence of adverse events, depth of sedation (Ramsey score), midazolam dose, total ketamine administration, opiate administration, total sedation time, and time to PED discharge were compared in patients who received ketamine alone versus those who received ketamine with midazolam. Logistic regression models were adjusted to evaluate for potential confounders.

Results
There was a statistically significant increase in the occurrence of hypoxia with coadministration of midazolam (5% vs 0%). When hypoxia occurred, it was mild and resolved with repositioning or administration of supplemental oxygen. Length of sedation was increased in sedations with coadministration of benzodiazepines by approximately 3.5 minutes. Time to PED discharge was not significantly different. There was no significant difference in depth of sedation, ketamine dose administered, end-tidal CO2 measurements, administration of positive pressure ventilation, vomiting, agitation, or overall occurrence of adverse events. No patients developed apnea or laryngospasm.

Conclusions
This study showed a low rate of adverse events in pediatric sedation for orthopedic reduction with ketamine alone or ketamine with midazolam. There was an increased occurrence of hypoxia with coadministration of midazolam and an increase in the length of sedation. This study showed no difference in depth of sedation based on Ramsay scores when midazolam was coadministered. Information on the orthopedic reduction and provider satisfaction was not collected.
The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians
Authors: Martin Colette , Capilla-Lasheras Pablo , Monaghan Pat , Burraco Pablo 
Published: August 2024

Among human actions threatening biodiversity, the release of anthropogenic chemical pollutants which have become ubiquitous in the environment, is a major concern. Chemical pollution can induce damage to macromolecules by causing the overproduction of reactive oxygen species, affecting the redox balance of animals. In species undergoing metamorphosis (i.e. the vast majority of the extant animal species), antioxidant responses to chemical pollution may differ between pre- and post-metamorphic stages. Here, we meta-analysed (
N
= 104 studies,
k =
2283 estimates) the impact of chemical pollution on redox balance across the three major amphibian life stages (embryo, tadpole, adult). Before metamorphosis, embryos did not experience any redox change while tadpoles activate their antioxidant pathways and do not show increased oxidative damage from pollutants. Tadpoles may have evolved stronger defences against pollutants to reach post-metamorphic life stages. In contrast, post-metamorphic individuals show only weak antioxidant responses and marked oxidative damage in lipids. The type of pollutant (i.e. organic versus inorganic) has contrasting effects across amphibian life stages. Our findings show a divergent evolution of the redox balance in response to pollutants across life transitions of metamorphosing amphibians, most probably a consequence of differences in the ecological and developmental processes of each life stage.
Transcripts and genomic intervals associated with variation in metabolite abundance in maize leaves under field conditions
Authors: Mathivanan Ramesh Kanna , Pederson Connor , Turkus Jonathan , Shrestha Nikee , Torres-Rodriguez J. Vladimir , Mural Ravi V. , Obata Toshihiro , Schnable James C. 
Published: August 2024

ABSTRACTPlants exhibit extensive environment-dependent intraspecific metabolic variation, which likely plays a role in determining variation in whole plant phenotypes. However, much of the work seeking to use natural variation to link genes and transcript’s impacts on plant metabolism has employed data from controlled environments. Here we generate and employ data on variation in the abundance of twenty-six metabolites across 660 maize inbred lines under field conditions. We employ these data and previously published transcript and whole plant phenotype data reported for the same field experiment to identify both genomic intervals (through genome-wide association studies) and transcripts (through both transcriptome-wide association studies and an explainable AI approach based on the random forest) associated with variation in metabolite abundance. Both genome-wide association and random forest-based methods identified substantial numbers of significant associations including genes with plausible links to the metabolites they are associated with. In contrast, the transcriptome-wide association identified only six significant associations. In three cases, genetic markers associated with metabolic variation in our study colocalized with markers linked to variation in non-metabolic traits scored in the same experiment. We speculate that the poor performance of transcriptome-wide association studies in identifying transcript-metabolite associations may reflect a high prevalence of non-linear interactions between transcripts and metabolites and/or a bias towards rare transcripts playing a large role in determining intraspecific metabolic variation.
CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization
Authors: Drouillard Donovan , Halyko Michael , Cinquegrani Elizabeth , McAllister Donna , Peterson Francis C. , Marchese Adriano , Dwinell Michael B. 
Published: August 2024

ABSTRACTAcute myeloid leukemia (AML) is a malignancy of immature myeloid blast cells with stem-like and chemoresistant cells being retained in the bone marrow through CXCL12-CXCR4 signaling. Current CXCR4 inhibitors mobilize AML cells into the bloodstream where they become more chemosensitive have failed to improve patient survival, likely reflecting persistent receptor localization on target cells. Here we characterize the signaling properties of CXCL12-locked dimer (CXCL12-LD), a bioengineered variant of the dimeric CXCL12 structure. CXCL12-LD binding resulted in lower levels of G protein, β-arrestin, and intracellular calcium mobilization, consistent with the locked dimer being a partial agonist of CXCR4. Further, CXCL12-LD failed to induce chemotaxis in AML cells. Despite these partial agonist properties, CXCL12-LD increased CXCR4 internalization compared to wildtype and locked-monomer forms of CXCL12. Analysis of a previously published AML transcriptomic data showed CXCR4 positive AML cells co-express genes involved in chemoresistance and maintenance of a blast-like state. The CXCL12-LD partial agonist effectively mobilized stem cells into the bloodstream in mice suggesting a potential role for their use in targeting CXCR4. Together, our results suggest that enhanced internalization by CXCL12-LD partial agonist signaling can avoid pharmacodynamic tolerance and may identify new avenues to better target GPCRs.
Maize genetic diversity identifies moisture-dependent root-branch signaling pathways
Authors: Scharwies Johannes D. , Clarke Taylor , Zheng Zihao , Dinneny Andrea , Birkeland Siri , Veltman Margaretha A. , Sturrock Craig J. , Banda Jason , Torres-Martínez Héctor H. , Viana Willian G. , Khare Ria , Kieber Joseph , Pandey Bipin K. , Bennett Malcolm , Schnable Patrick S. , Dinneny José R. 
Published: August 2024

AbstractPlants grow complex root systems to extract unevenly distributed resources from soils. Spatial differences in soil moisture are perceived by root tips leading to the patterning of new root branches towards available water, a process called hydropatterning. Little is known about hydropatterning behavior and its genetic basis in crops plants. Here, we develop an assay to measure hydropatterning in maize and reveal substantial differences between tropical/subtropical and temperate maize breeding germplasm that likely resulted from divergent selection. Genetic dissection of hydropatterning confirmed the regulatory role of auxin and revealed that the gaseous hormone ethylene acts to locally inhibit root branching from air-exposed tissues. These findings demonstrate the crop relevance of hydropatterning and establish its genetic basis.
Modeling the benefits of virus discovery and pandemic virus identification
Authors: Jeyapragasan Geetha , Graabak Jakob , Luby Stephen , Esvelt Kevin M. 
Published: August 2024

AbstractPreventing and mitigating future zoonotic pandemics are global health priorities, but there are few quantitative estimates of how best to target interventions. Here we construct a mathematical model to evaluate the benefits of 1) virus discovery and sequencing (VDS) in animals and 2) pandemic virus identification (PVI) via laboratory characterization of pandemic potential. Drawing on historical data and expert surveys of One Health and vaccine researchers, we estimate that intensifying virus discovery efforts by three-fold could prevent between 0 and 1.46 million expected deaths per decade by improving non-pharmaceutical interventions and broad-spectrum vaccines. In contrast, because researchers estimate that there are well over a hundred pandemic-capable viruses in nature, identification through laboratory characterization would prevent 48,000 deaths per decade [10,500; 93,600], or just ∼0.62% of expected pandemic deaths. Further identifications would offer diminishing returns. Given wide-ranging survey responses and limited cost-effectiveness compared to proven global health interventions such as insecticide-treated bed nets, our model suggests that health establishments aiming to mitigate future pandemics should focus on monitoring spillover hotspots and empowering local communities to detect, sequence, and suppress nascent epidemics rather than characterizing pandemic potential in laboratories.
Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state
Authors: Watanabe Keita , Yamano Mayu , Miyamoto Junki , Ohue-Kitano Ryuji , Masujima Yuki , Sasahara Daiki , Mouri Yuki , Kono Nozomu , Inuki Shunsuke , Osakada Fumitaka , Nagaoka Kentaro , Aoki Junken , Sugiura Yuki , Ohno Hiroaki , Kondoh Eiji , Kimura Ikuo 
Published: August 2024

AbstractSex steroid hormones such as progesterone play a pivotal role in reproductive functions and maintaining pregnancy; however, the impact of progesterone on the interaction between mother and embryo is unclear. Here, we demonstrate that the relationship between maternal progesterone and membrane progesterone receptor epsilon (mPRε) in adipose tissue regulates embryonic nutritional environment and growth after birth in mice. The activation of adipose mPRε by increased progesterone during pregnancy enhanced maternal insulin resistance through the production of prostaglandins, thereby efficiently providing glucose to embryos. The offspring of mPRε-deficient mothers exhibited metabolic dysfunction, whereas mPRε-deficient mothers with high-fat-diet-induced obesity exhibited improved insulin sensitivity. These findings establish the importance of progesterone as a nutritional regulator between mother and embryo, and suggest that mPRε modulators could be developed to treat pregnant glycemic control disorders such as gestational diabetes mellitus, as well as metabolic syndrome in offspring.Graphical Abstract
Muon-induced collisional flavor instability in core-collapse supernova
Authors: Liu Jiabao , Nagakura Hiroki , Akaho Ryuichiro , Ito Akira , Zaizen Masamichi , Furusawa Shun , Yamada Shoichi 
Published: August 2024

Neutrinos are known to undergo flavor conversion among their three flavors. In the theoretical modeling of core-collapse supernova, there has been a great deal of attention to recent discoveries of a new type of neutrino flavor conversions, namely collisional flavor instability (CFI), in which the instability is induced by the flavor-dependent decoherence due to the disparity of neutrino-matter interactions among flavors. In this paper, we study how the appearance of on-shell muons and associated neutrino-matter interactions can impact CFIs based on linear stability analysis of flavor conversions. Some striking results emerge from the present study. First, we analytically show that breaking beta and pair equilibrium is a necessary condition to trigger CFIs. This also indicates that CFIs with on-shell muons could appear in eτ and μτ neutrino mixing sectors in very high-density region (≳1013  g/cm3), exhibiting a possibility of large impacts of CFIs on core-collapse supernova. Second, resonancelike CFIs, having a much higher growth rate than normal CFIs, can be triggered by muons. The resonance point of CFIs is different between eτ and μτ sectors; the former (latter) occurs at μe(μ)=μn−μp, where μi denotes the chemical potential of i constitute (n and p represent neutrons and protons, respectively). Our result suggests that the nonlinear evolution of CFI with on-shell muons would induce flavor conversions with the complex interplay among all three different neutrino-mixing sectors.

Published by the American Physical Society
2024
“Follow the leader”: how inclusive leaders inspire followers to perform well through strengths use
Authors: Gürbüz Sait , Van der Heijden Beatrice , Freese Charissa , Brouwers Evelien P.M. 
Published: August 2024

PurposeWhile previous research in career studies has highlighted the positive impact of several leadership behaviors on followers’ work and career success, less is known about how the emergent topic of inclusive leadership shapes followers’ task performance. Using an inclusive leadership approach and job demands-resources theory, we developed a novel sequential mediation model in which inclusive leadership indirectly facilitates followers’ performance through self-initiating behavior and work motivation. Specifically, we aimed to investigate whether inclusive leaders encourage followers to show enhanced task performance through strengths use and work engagement.Design/methodology/approachA representative sample of 278 Dutch employees from diverse organizations was surveyed at three different time points.FindingsThe results of structural equation modeling evidenced that inclusive leadership was indirectly related to follower task performance, initially through the utilization of strengths and subsequently through work engagement over time. When leaders exhibited behaviors that were inclusive in nature, they encouraged their followers to make use of their strengths at work. Such leadership actions boosted the work engagement of their followers and led to enhanced task performance.Originality/valueWe develop and test a novel sequential mediation model that explores how inclusive leadership fosters improved task performance among followers by promoting the utilization of strengths and subsequent work engagement. This sheds light on the mechanisms through which inclusive leadership contributes to follower performance, a crucial indicator in shaping sustainable career trajectories.
Mapping the jungle: a bibliometric analysis of the application of Gestalt literature in management research
Authors: Mahajan Yogesh , Tatia Karnawat Amrita , Mann Shikha , Sharma Vinod 
Published: August 2024

Purpose
This paper aims to examine the research conducted between 1938 and 2023 on applying Gestalt principles in management research, focusing on publishing and citation trends in this field.

Design/methodology/approach
A systematic literature review was conducted using PRISMA criteria, forming a three-phase strategy. A total of 394 articles from the Scopus database were reviewed. Bibliometric analysis involving co-citation and co-word analysis was used to explore the intellectual structure of the research area.

Findings
Eight application clusters were identified through co-citation analysis using Gestalt as a keyword. Co-word analysis revealed key themes and keywords over the period. Substantial literature exists on topics like organization, strategy, physical servicescape, coaching, learning and human resource management. However, Gestalt principles are minimally applied to online retail, social media, website design, mobile app design and emerging areas like Industry 4.0.

Practical implications
The study suggests that Gestalt principles can enhance marketing, communication, decision-making and leadership, according to the study. Understanding Gestalt concepts and how different industries adapt and apply them helps enable cross-industry learning, where successful strategies from one sector can be creatively implemented in others to solve problems.

Originality/value
This study fills a significant gap in the literature by highlighting the underexplored application of Gestalt principles in emerging business and management sectors. It provides a comprehensive discussion on future research directions and identifies specific areas where Gestalt principles can be innovatively applied, offering fresh insights and expanding the theoretical and practical understanding of their utility in modern business contexts.
The interplay between multichannel integration quality, service convenience, service experience, multichannel perceived value and e-WoM
Authors: Addae John Agyekum , Boakye Kwabena Gyasi , Ampong George Oppong Appiagyei , Anyigba Hod , Majeed Mohammed , Abubakari Aidatu , Ofori Kwame Simpe 
Published: August 2024

PurposeThe study's goal is to assess the influence of multichannel integration quality on perceived value, service convenience and service experience in a multichannel banking context. Furthermore, the study investigated the impact of perceived value, service convenience and service experience on positive electronic word of mouth (e-WoM).Design/methodology/approachData were collected from 527 respondents using online surveys distributed on various social media platforms in Ghana. The data were analysed using the partial least squares approach to structural equation modelling.FindingsThe results showed that multichannel integration quality influences consumers' perceptions of value and service experience favourably. It also showed that the two factors influencing service convenience were service experience and perceived value. Further, the research revealed a significant relationship between positive electronic word of mouth and perceived value, service convenience and service experience.Practical implicationsThe study adds to the existing body of knowledge on multichannel integration by empirically testing the relationship between multichannel integration quality and consumer response in the context of multichannel banking.Originality/valueThe study is one of a few that provide important insights into the growing body of literature on multichannel integration quality from the consumers' perspective. The study further develops a model that explicates the relationship between multichannel integration quality, perceived value, service convenience and e-WoM.
Measuring consumer perceptions of online retail platform corporate sustainable development: a scale development and validation
Authors: He Ai-Zhong , Wang Xing-Xin 
Published: August 2024

PurposeOnline retail platform corporate sustainable development (ORPCSD) has garnered significant interest and appeal among consumers. However, no scale has been developed to measure consumer perceptions of ORPCSD. Therefore, this study aimed to delineate the conceptual framework and dimensions underlying these perceptions and construct a reliable and valid measurement tool.Design/methodology/approachThis study employed established qualitative and quantitative methods in two studies. In the first study, the dimensions and measurement items of consumer perceptions of ORPCSD were proposed using the grounded method. In the second study, the measurement scale was refined and validated using exploratory factor analysis, confirmatory factor analysis, and nomological validity examination.FindingsThe results indicated that consumer perception of ORPCSD consisted of three dimensions: economic, social, and environmental sustainability. The measurement scale for these dimensions comprised 25 items, demonstrating excellent psychometric properties.Originality/valueThis study contributes original insights by enhancing the current understanding of consumer perceptions of ORPCSD. Additionally, it provides researchers and managers with psychometric metrics to gauge these perceptions and offers actionable strategies for sustainable marketing initiatives.
Effect of phosphide additives on the tribological properties of polyethylsiloxane (PES) in Si3N4 and M50 system
Authors: Yue Luo , Meng Yan , Lee Eunji , Bai Pengpeng , Pan Yingzhuo , Wei Peng , Cheng Jie , Meng Yonggang , Tian Yu 
Published: August 2024

Purpose
The incorporation of phosphide additives is regarded as a highly effective strategy for enhancing the lubricative qualities of base oils. This study aims to assess the lubrication behavior and efficacy of various phosphide additives in polyethylsiloxane (PES) through the employment of the Schwingum Reibung Verschleiss test methodology, across a temperature range from ambient to 300°C.

Design/methodology/approach
PES demonstrated commendable lubrication capabilities within the Si3N4/M50 system, primarily attributable to the Si-O frictional reaction film at the interface. This film undergoes disintegration as the temperature escalates, leading to heightened wear. Moreover, the phosphide additives were found to ameliorate the issues encountered by PES in the Si3N4/M50 system, characterized by numerous boundary lubrication failure instances. A chemical film comprising P-Fe-O was observed to form at the interface; however, at elevated temperatures, disintegration of some phosphide films precipitated lubrication failures, as evidenced by a precipitous rise in the coefficient of friction.

Findings
The results show that a phosphide reactive film can be formed and a reduction in wear rate is achieved, which is reduced by 64.7% from 2.98 (for pure PES at 300°C) to 1.05 × 10–9 μm3/N m (for triphenyl phosphite at 300°C).

Originality/value
The data derived from this investigation offer critical insights for the selection and deployment of phosphide additives within high-temperature lubrication environments pertinent to PES.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-04-2024-0139/