bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personal religion: a productive category for the study of ancient Greek religion?
Authors: Kindt Julia 
Published: October 2015

Abstract:This article investigates the scope and meaning of ancient Greek personal religion as an additional dimension - besides official (polis) religion - in which the ancient Greek religious experience articulates itself. I show how ‘personal religion’ is a rather broad and amorphous scholarly category for a number of religious beliefs and practices that, in reflecting individual engagement with the supernatural, do not fit into our conception of polis religion. At the same time, I argue that personal religion should not be seen simply as that which is not official Greek religion. Nor is personal religion simply ‘private’ religion, oikos religion or the religion of those who had no voice in the sphere of politics (metics, women). Rather, ‘personal religion’ combines aspects of public and private. It is a productive category of scholarly research insofar as it helps us to appreciate the whole spectrum of ways individuals in the ancient Greek city received and (if necessary) altered culturally given religious beliefs and practices. Indeed, the examples discussed in this paper reveal a very Greek conversation about the question of what should count as a religious sign and who was to determine its meaning.
The ‘Ϝhεδιέστας’ inscription from Archaic Argos (SEG 11:314): a reconsideration
Authors: Probert Philomen , Dickey Eleanor 
Published: October 2015

Abstract:This article offers a re-edition of SEG 11:314, Argos inventory number E274, based on re-examination of the stone and of recently rediscovered squeezes preserving material now lost from the stone; these allow improved readings in numerous places. We also offer a reinterpretation of the disputed syntax of the last three lines, which we translate ‘As for the things with which a δαμιοργóς is to compel (him to make amends), the ἀμφίπολος is to give thought to these things’.
The end of the ancient Olympics and other contests: why the agonistic circuit collapsed in late antiquity
Authors: Remijsen Sofie 
Published: October 2015

Abstract:In the second and third centuries AD, many of the cities in the eastern Mediterranean could boast about having their own athletic games. In the fourth century, however, these games quickly declined. In recent years, the traditional explanations for the end of athletic games, most prominently the supposed ban by Theodosius, have been proven unfounded. This paper proposes an alternative explanation: institutional and financial changes hindered the successful organization of athletic contests by the cities in the fourth and fifth centuries. In order to show the effect of these changes, this paper first offers a detailed analysis of how athletic contests were founded and funded in the early imperial period. It then examines how and to what extent these procedures and funds were affected by changes in late antiquity. The decline was not caused by a general financial crisis - in fact the estates (partially) funding the games remained a stable form of financing. Instead the shift of power to a centralized bureaucracy limited the cities in their administration of the games: they could no longer independently meet deficits in the agonistic budget from the city treasury and had to rely increasingly on elite sponsors, whose ambitions focused mainly on the provincial capitals and who gradually lost their interest in athletics.
Outbreak of hospital-acquired gastroenteritis and invasive infection caused byListeria monocytogenes, Finland, 2012
Authors: JACKS A. , PIHLAJASAARI A. , VAHE M. , MYNTTI A. , KAUKORANTA S.-S. , ELOMAA N. , SALMENLINNA S. , RANTALA L. , LAHTI K. , HUUSKO S. , KUUSI M. , SIITONEN A. , RIMHANEN-FINNE R. 
Published: October 2015

SUMMARYDuring one week in July 2012, two patients from the same ward at the municipal hospital in Vaasa, Finland, were diagnosed with septicaemia caused byListeria monocytogenes. An outbreak investigation revealed eight concomitant cases of febrile gastroenteritis caused byL. monocytogeneson the same ward. Median age of the cases was 82 years and median incubation time for listerial gastroenteritis was 21 h (range 9–107). An additional 10 cases of invasive listeriosis caused by the same outbreak strain were identified across the whole country during the summer of 2012. Environmental investigation at the affected municipal hospital ward revealed ready-sliced meat jelly as the suspected source of the infection. During inspection of the meat jelly production plant, one pooled sample taken from a floor drain and a trolley wheel in the food processing environment was positive for the outbreak strain ofL. monocytogenes. After the producer stopped the production of meat jelly, no further cases of listeriosis with the outbreak strain were identified via nationwide surveillance.
Observational signatures of self-destructive civilizations
Authors: Stevens Adam , Forgan Duncan , James Jack O'Malley 
Published: October 2015

AbstractWe address the possibility that intelligent civilizations that destroy themselves could present signatures observable by humanity. Placing limits on the number of self-destroyed civilizations in the Milky Way has strong implications for the final three terms in Drake's Equation, and would allow us to identify which classes of solution to Fermi's Paradox fit with the evidence (or lack thereof). Using the Earth as an example, we consider a variety of scenarios in which humans could extinguish their own technological civilization. Each scenario presents some form of observable signature that could be probed by astronomical campaigns to detect and characterize extrasolar planetary systems. Some observables are unlikely to be detected at interstellar distances, but some scenarios are likely to produce significant changes in atmospheric composition that could be detected serendipitously with next-generation telescopes. In some cases, the timing of the observation would prove crucial to detection, as the decay of signatures is rapid compared with humanity's communication lifetime. In others, the signatures persist on far longer timescales.
Microbiome shifts and the inhibition of quorum sensing by Black Band Disease cyanobacteria
Authors: Meyer Julie L , Gunasekera Sarath P , Scott Raymond M , Paul Valerie J , Teplitski Max 
Published: October 2015

Abstract
Disruption of the microbiome often correlates with the appearance of disease symptoms in metaorganisms such as corals. In Black Band Disease (BBD), a polymicrobial disease consortium dominated by the filamentous cyanobacterium Roseofilum reptotaenium displaces members of the epibiotic microbiome. We examined both normal surface microbiomes and BBD consortia on Caribbean corals and found that the microbiomes of healthy corals were dominated by Gammaproteobacteria, in particular Halomonas spp., and were remarkably stable across spatial and temporal scales. In contrast, the microbial community structure in black band consortia was more variable and more diverse. Nevertheless, deep sequencing revealed that members of the disease consortium were present in every sampled surface microbiome of Montastraea, Orbicella and Pseudodiploria corals, regardless of the health status. Within the BBD consortium, we identified lyngbic acid, a cyanobacterial secondary metabolite. It strongly inhibited quorum sensing (QS) in the Vibrio harveyi QS reporters. The effects of lyngbic acid on the QS reporters depended on the presence of the CAI-1 receptor CqsS. Lyngbic acid inhibited luminescence in native coral Vibrio spp. that also possess the CAI-1-mediated QS. The effects of this naturally occurring QS inhibitor on bacterial regulatory networks potentially contribute to the structuring of the interactions within BBD consortia.
Designing bioinspired composite reinforcement architectures via 3D magnetic printing
Authors: Martin Joshua J. , Fiore Brad E. , Erb Randall M. 
Published: October 2015

AbstractDiscontinuous fibre composites represent a class of materials that are strong, lightweight and have remarkable fracture toughness. These advantages partially explain the abundance and variety of discontinuous fibre composites that have evolved in the natural world. Many natural structures out-perform the conventional synthetic counterparts due, in part, to the more elaborate reinforcement architectures that occur in natural composites. Here we present an additive manufacturing approach that combines real-time colloidal assembly with existing additive manufacturing technologies to create highly programmable discontinuous fibre composites. This technology, termed as ‘3D magnetic printing’, has enabled us to recreate complex bioinspired reinforcement architectures that deliver enhanced material performance compared with monolithic structures. Further, we demonstrate that we can now design and evolve elaborate reinforcement architectures that are not found in nature, demonstrating a high level of possible customization in discontinuous fibre composites with arbitrary geometries.
MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection
Authors: Kubinak Jason L. , Stephens W. Zac , Soto Ray , Petersen Charisse , Chiaro Tyson , Gogokhia Lasha , Bell Rickesha , Ajami Nadim J. , Petrosino Joseph F. , Morrison Linda , Potts Wayne K. , Jensen Peter E. , O’Connell Ryan M. , Round June L. 
Published: October 2015

AbstractThe presentation of protein antigens on the cell surface by major histocompatibility complex (MHC) molecules coordinates vertebrate adaptive immune responses, thereby mediating susceptibility to a variety of autoimmune and infectious diseases. The composition of symbiotic microbial communities (the microbiota) is influenced by host immunity and can have a profound impact on host physiology. Here we use an MHC congenic mouse model to test the hypothesis that genetic variation at MHC genes among individuals mediates susceptibility to disease by controlling microbiota composition. We find that MHC genotype significantly influences antibody responses against commensals in the gut, and that these responses are correlated with the establishment of unique microbial communities. Transplantation experiments in germfree mice indicate that MHC-mediated differences in microbiota composition are sufficient to explain susceptibility to enteric infection. Our findings indicate that MHC polymorphisms contribute to defining an individual’s unique microbial fingerprint that influences health.
Single-photon non-linear optics with a quantum dot in a waveguide
Authors: Javadi A. , Söllner I. , Arcari M. , Hansen S. Lindskov , Midolo L. , Mahmoodian S. , Kiršanskė G , Pregnolato T. , Lee E. H. , Song J. D. , Stobbe S. , Lodahl P. 
Published: October 2015

AbstractStrong non-linear interactions between photons enable logic operations for both classical and quantum-information technology. Unfortunately, non-linear interactions are usually feeble and therefore all-optical logic gates tend to be inefficient. A quantum emitter deterministically coupled to a propagating mode fundamentally changes the situation, since each photon inevitably interacts with the emitter, and highly correlated many-photon states may be created. Here we show that a single quantum dot in a photonic-crystal waveguide can be used as a giant non-linearity sensitive at the single-photon level. The non-linear response is revealed from the intensity and quantum statistics of the scattered photons, and contains contributions from an entangled photon–photon bound state. The quantum non-linearity will find immediate applications for deterministic Bell-state measurements and single-photon transistors and paves the way to scalable waveguide-based photonic quantum-computing architectures.
S-nitrosylation triggers ABI5 degradation to promote seed germination and seedling growth
Authors: Albertos Pablo , Romero-Puertas María C. , Tatematsu Kiyoshi , Mateos Isabel , Sánchez-Vicente Inmaculada , Nambara Eiji , Lorenzo Oscar 
Published: October 2015

AbstractPlant survival depends on seed germination and progression through post-germinative developmental checkpoints. These processes are controlled by the stress phytohormone abscisic acid (ABA). ABA regulates the basic leucine zipper transcriptional factor ABI5, a central hub of growth repression, while the reactive nitrogen molecule nitric oxide (NO) counteracts ABA during seed germination. However, the molecular mechanisms by which seeds sense more favourable conditions and start germinating have remained elusive. Here we show that ABI5 promotes growth via NO, and that ABI5 accumulation is altered in genetic backgrounds with impaired NO homeostasis. S-nitrosylation of ABI5 at cysteine-153 facilitates its degradation through CULLIN4-based and KEEP ON GOING E3 ligases, and promotes seed germination. Conversely, mutation of ABI5 at cysteine-153 deregulates protein stability and inhibition of seed germination by NO depletion. These findings suggest an inverse molecular link between NO and ABA hormone signalling through distinct posttranslational modifications of ABI5 during early seedling development.
The post-vaccine microevolution of invasive Streptococcus pneumoniae
Authors: Cremers Amelieke J. H. , Mobegi Fredrick M. , de Jonge Marien I. , van Hijum Sacha A. F. T. , Meis Jacques F. , Hermans Peter W. M. , Ferwerda Gerben , Bentley Stephen D. , Zomer Aldert L. 
Published: October 2015

AbstractThe 7-valent pneumococcal conjugated vaccine (PCV7) has affected the genetic population of Streptococcus pneumoniae in pediatric carriage. Little is known however about pneumococcal population genomics in adult invasive pneumococcal disease (IPD) under vaccine pressure. We sequenced and serotyped 349 strains of S. pneumoniae isolated from IPD patients in Nijmegen between 2001 and 2011. Introduction of PCV7 in the Dutch National Immunization Program in 2006 preluded substantial alterations in the IPD population structure caused by serotype replacement. No evidence could be found for vaccine induced capsular switches. We observed that after a temporary bottleneck in gene diversity after the introduction of PCV7, the accessory gene pool re-expanded mainly by genes already circulating pre-PCV7. In the post-vaccine genomic population a number of genes changed frequency, certain genes became overrepresented in vaccine serotypes, while others shifted towards non-vaccine serotypes. Whether these dynamics in the invasive pneumococcal population have truly contributed to invasiveness and manifestations of disease remains to be further elucidated. We suggest the use of whole genome sequencing for surveillance of pneumococcal population dynamics that could give a prospect on the course of disease, facilitating effective prevention and management of IPD.
Visual Identification of Light-Driven Breakage of the Silver-Dithiocarbamate Bond by Single Plasmonic Nanoprobes
Authors: Gao Peng Fei , Yuan Bin Fang , Gao Ming Xuan , Li Rong Sheng , Ma Jun , Zou Hong Yan , Li Yuan Fang , Li Ming , Huang Cheng Zhi 
Published: October 2015

AbstractInsight into the nature of metal-sulfur bond, a meaningful one in life science, interface chemistry and organometallic chemistry, is interesting but challenging. By utilizing the localized surface plasmon resonance properties of silver nanoparticles, herein we visually identified the photosensitivity of silver-dithiocarbamate (Ag-DTC) bond by using dark field microscopic imaging (iDFM) technique at single nanoparticle level. It was found that the breakage of Ag-DTC bond could be accelerated effectively by light irradiation, followed by a pH-dependent horizontal or vertical degradation of the DTC molecules, in which an indispensable preoxidation process of the silver was at first disclosed. These findings suggest a visualization strategy at single plasmonic nanoparticle level which can be excellently applied to explore new stimulus-triggered reactions and might also open a new way to understand traditional organic reaction mechanisms.
DNA methylation signatures of long intergenic noncoding RNAs in porcine adipose and muscle tissues
Authors: Zhou Zhong-Yin , Li Aimin , Wang Li-Gang , Irwin David M , Liu Yan-Hu , Xu Dan , Han Xu-Man , Wang Lu , Wu Shi-Fang , Wang Li-Xian , Xie Hai-Bing , Zhang Ya-Ping 
Published: October 2015

AbstractLong intergenic noncoding RNAs (lincRNAs) are one of the major unexplored components of genomes. Here we re-analyzed a published methylated DNA immunoprecipitation sequencing (MeDIP-seq) dataset to characterize the DNA methylation pattern of pig lincRNA genes in adipose and muscle tissues. Our study showed that the methylation level of lincRNA genes was higher than that of mRNA genes, with similar trends observed in comparisons of the promoter, exon or intron regions. Different methylation pattern were observed across the transcription start sites (TSS) of lincRNA and protein-coding genes. Furthermore, an overlap was observed between many lincRNA genes and differentially methylated regions (DMRs) identified among different breeds of pigs, which show different fat contents, sexes and anatomic locations of tissues. We identify a lincRNA gene, linc-sscg3623, that displayed differential methylation levels in backfat between Min and Large White pigs at 60 and 120 days of age. We found that a demethylation process occurred between days 150 and 180 in the Min and Large White pigs, which was followed by remethylation between days 180 and 210. These results contribute to our understanding of the domestication of domestic animals and identify lincRNA genes involved in adipogenesis and muscle development.
Highly sensitive and selective sugar detection by terahertz nano-antennas
Authors: Lee Dong-Kyu , Kang Ji-Hun , Lee Jun-Seok , Kim Hyo-Seok , Kim Chulki , Hun Kim Jae , Lee Taikjin , Son Joo-Hiuk , Park Q-Han , Seo Minah 
Published: October 2015

AbstractMolecular recognition and discrimination of carbohydrates are important because carbohydrates perform essential roles in most living organisms for energy metabolism and cell-to-cell communication. Nevertheless, it is difficult to identify or distinguish various carbohydrate molecules owing to the lack of a significant distinction in the physical or chemical characteristics. Although there has been considerable effort to develop a sensing platform for individual carbohydrates selectively using chemical receptors or an ensemble array, their detection and discrimination limits have been as high in the millimolar concentration range. Here we show a highly sensitive and selective detection method for the discrimination of carbohydrate molecules using nano-slot-antenna array-based sensing chips which operate in the terahertz (THz) frequency range (0.5–2.5 THz). This THz metamaterial sensing tool recognizes various types of carbohydrate molecules over a wide range of molecular concentrations. Strongly localized and enhanced terahertz transmission by nano-antennas can effectively increase the molecular absorption cross sections, thereby enabling the detection of these molecules even at low concentrations. We verified the performance of nano-antenna sensing chip by both THz spectra and images of transmittance. Screening and identification of various carbohydrates can be applied to test even real market beverages with a high sensitivity and selectivity.
Overshoot during phenotypic switching of cancer cell populations
Authors: Sellerio Alessandro L. , Ciusani Emilio , Ben-Moshe Noa Bossel , Coco Stefania , Piccinini Andrea , Myers Christopher R. , Sethna James P. , Giampietro Costanza , Zapperi Stefano , La Porta Caterina A. M. 
Published: October 2015

AbstractThe dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a subpopulation of cancer stem cells (CSCs), or are stochastic transitions that mutate differentiated cancer cells to CSCs important? Here we argue that regulation must also be important. We sort human melanoma cells using three distinct cancer stem cell (CSC) markers — CXCR6, CD271 and ABCG2 — and observe that the fraction of non-CSC-marked cells first overshoots to a higher level and then returns to the level of unsorted cells. This clearly indicates that the CSC population is homeostatically regulated. Combining experimental measurements with theoretical modeling and numerical simulations, we show that the population dynamics of cancer cells is associated with a complex miRNA network regulating the Wnt and PI3K pathways. Hence phenotypic switching is not stochastic, but is tightly regulated by the balance between positive and negative cells in the population. Reducing the fraction of CSCs below a threshold triggers massive phenotypic switching, suggesting that a therapeutic strategy based on CSC eradication is unlikely to succeed.
Dynamics of quantum correlation between separated nitrogen-vacancy centers embedded in plasmonic waveguide
Authors: Yang Wan-li , An Jun-Hong , Zhang Cheng-jie , Chen Chang-yong , Oh C. H. 
Published: October 2015

AbstractWe investigate the dynamics of quantum correlation between two separated nitrogen vacancy centers (NVCs) placed near a one-dimensional plasmonic waveguide. As a common medium of the radiation field of NVCs propagating, the plasmonic waveguide can dynamically induce quantum correlation between the two NVCs. It is interesting to find that such dynamically induced quantum correlation can be preserved in the long-time steady state by locally applying individual driving on the two NVCs. In particular, we also show that a large degree of quantum correlation can be established by this scheme even when the distance between the NVCs is much larger than their operating wavelength. This feature may open new perspectives for devising active decoherence-immune solid-state optical devices and long-distance NVC-based quantum networks in the context of plasmonic quantum electrodynamics.
Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p
Authors: Kershaw Christopher J. , Costello Joseph L. , Talavera David , Rowe William , Castelli Lydia M. , Sims Paul F. G. , Grant Christopher M. , Ashe Mark P. , Hubbard Simon J. , Pavitt Graham D. 
Published: October 2015

AbstractThe PUF family of RNA-binding proteins regulate gene expression post-transcriptionally. Saccharomyces cerevisiae Puf3p is characterised as binding nuclear-encoded mRNAs specifying mitochondrial proteins. Extensive studies of its regulation of COX17 demonstrate its role in mRNA decay. Using integrated genome-wide approaches we define an expanded set of Puf3p target mRNAs and quantitatively assessed the global impact of loss of PUF3 on gene expression using mRNA and polysome profiling and quantitative proteomics. In agreement with prior studies, our sequencing of affinity-purified Puf3-TAP associated mRNAs (RIP-seq) identified mRNAs encoding mitochondrially-targeted proteins. Additionally, we also found 720  new mRNA targets that predominantly encode proteins that enter the nucleus. Comparing transcript levels in wild-type and puf3∆ cells revealed that only a small fraction of mRNA levels alter, suggesting Puf3p determines mRNA stability for only a limited subset of its target mRNAs. Finally, proteomic and translatomic studies suggest that loss of Puf3p has widespread, but modest, impact on mRNA translation. Taken together our integrated multi-omics data point to multiple classes of Puf3p targets, which display coherent post-transcriptional regulatory properties and suggest Puf3p plays a broad, but nuanced, role in the fine-tuning of gene expression.