bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Risk of Stroke or Clinical Impairment After Stereotactic Radiosurgery for ARUBA-Eligible Patients
Authors: Pollock Bruce E. , Link Michael J. , Brown Robert D. 
Published: January 2013

Background and Purpose—
The best management of patients with unruptured brain arteriovenous malformations (BAVM) is controversial. In this study, we analyzed the stroke rate and functional outcomes of patients having stereotactic radiosurgery (SRS) for unruptured BAVM using the same eligibility criteria and primary end points as the ARUBA trial.

Methods—
Retrospective observational study of 174 ARUBA-eligible patients having SRS from 1990 to 2005.

Results—

The median follow-up after SRS was 64 months. Fifteen patients (8.7%) had a hemorrhagic stroke at a median of 21 months after SRS. Six patients (3.5%) had a focal neurological deficit and 4 patients died (2.3%). The risk of stroke or death was 10.3% at 5 years and 11.5% at 10 years. Twelve additional patients (6.9%) had a focal neurological deficit from either radiation-related complications (n=7) or subsequent resection (n=5). The risk of patients’ having clinical impairment (modified Rankin Score ≥2) was 8.4% at 5 years and 12.0% at 10 years. Increasing BAVM volume was associated with both stroke or death (hazard ratio=1.06; 95% confidence interval, 1.0–1.11;
P
=0.04) and clinical impairment (hazard ratio=1.06; 95% confidence interval, 1.01–1.09;
P
=0.01). The 10-year risk of stroke or death and clinical impairment for patients with BAVM ≤5.6 cm
3
was 5% and 4%, respectively.

Conclusions—
The observed risk of stroke or death after SRS was approximately 2% per year for the first 5 years after SRS, declining to 0.2% annually for years 6 to 10. Patients with small volume BAVM may benefit from SRS compared with the natural history of unruptured BAVM over the planned follow-up interval of the ARUBA trial (5–10 years).
Mesenchymal Stem Cells Prevent Hydrocephalus After Severe Intraventricular Hemorrhage
Authors: Ahn So Yoon , Chang Yun Sil , Sung Dong Kyung , Sung Se In , Yoo Hye Soo , Lee Jung Hee , Oh Won Il , Park Won Soon 
Published: January 2013

Background and Purpose—
Severe intraventricular hemorrhage (IVH) in premature infants and the ensuing posthemorrhagic hydrocephalus cause significant mortality and neurological disabilities, and there are currently no effective therapies. This study determined whether intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells prevents posthemorrhagic hydrocephalus development and attenuates brain damage after severe IVH in newborn rats.

Methods—

To induce severe IVH, 100 μL of blood was injected into each lateral ventricle of postnatal day 4 (P4) Sprague-Dawley rats. Human umbilical cord blood-derived mesenchymal stem cells or fibroblasts (1×10
5
) were transplanted intraventricularly under stereotaxic guidance at P6. Serial brain MRI and behavioral function tests, such as the negative geotaxis test and rotarod test, were performed. At P32, brain tissue and cerebrospinal fluid were obtained for histological and biochemical analyses.

Results—
Intraventricular transplantation of umbilical cord blood-derived mesenchymal stem cells, but not fibroblasts, prevented posthemorrhagic hydrocephalus development and significantly attenuated impairment on behavioral tests; the increased terminal deoxynycleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling-positive cells; increased expression of inflammatory cytokines, such as interleukin-1α, interleukin-1β, interleukin-6, and tumor necrosis factor-α; increased astrogliosis; and reduced corpus callosal thickness and myelin basic protein expression after inducing severe IVH.

Conclusions—
Intraventricular transplantation of umbilical cord blood-derived mesenchymal stem cells significantly attenuated the posthemorrhagic hydrocephalus and brain injury after IVH. This neuroprotective mechanism appears to be mediated by the anti-inflammatory effects of these cells.
Have Aerosols Caused the Observed Atlantic Multidecadal Variability?
Authors: Zhang Rong , Delworth Thomas L. , Sutton Rowan , Hodson Daniel L. R. , Dixon Keith W. , Held Isaac M. , Kushnir Yochanan , Marshall John , Ming Yi , Msadek Rym , Robson Jon , Rosati Anthony J. , Ting MingFang , Vecchi Gabriel A. 
Published: January 2013

Abstract
Identifying the prime drivers of the twentieth-century multidecadal variability in the Atlantic Ocean is crucial for predicting how the Atlantic will evolve in the coming decades and the resulting broad impacts on weather and precipitation patterns around the globe. Recently, Booth et al. showed that the Hadley Centre Global Environmental Model, version 2, Earth system configuration (HadGEM2-ES) closely reproduces the observed multidecadal variations of area-averaged North Atlantic sea surface temperature in the twentieth century. The multidecadal variations simulated in HadGEM2-ES are primarily driven by aerosol indirect effects that modify net surface shortwave radiation. On the basis of these results, Booth et al. concluded that aerosols are a prime driver of twentieth-century North Atlantic climate variability. However, here it is shown that there are major discrepancies between the HadGEM2-ES simulations and observations in the North Atlantic upper-ocean heat content, in the spatial pattern of multidecadal SST changes within and outside the North Atlantic, and in the subpolar North Atlantic sea surface salinity. These discrepancies may be strongly influenced by, and indeed in large part caused by, aerosol effects. It is also shown that the aerosol effects simulated in HadGEM2-ES cannot account for the observed anticorrelation between detrended multidecadal surface and subsurface temperature variations in the tropical North Atlantic. These discrepancies cast considerable doubt on the claim that aerosol forcing drives the bulk of this multidecadal variability.
Wave-Breaking Characteristics of Northern Hemisphere Winter Blocking: A Two-Dimensional Approach
Authors: Masato Giacomo , Hoskins Brian J. , Woollings Tim 
Published: January 2013

Abstract
This paper generalizes and applies recently developed blocking diagnostics in a two-dimensional (2D) latitude–longitude context, which takes into consideration both mid- and high-latitude blocking. These diagnostics identify characteristics of the associated wave breaking as seen in the potential temperature θ on the dynamical tropopause, particularly the cyclonic or anticyclonic direction of wave breaking (“DB index”) and the relative intensity (“RI index”) of the air masses that contribute to blocking formation. The methodology is extended to a 2D domain and a cluster technique is deployed to classify mid- and high-latitude blocking according to the wave-breaking characteristics. Midlatitude blocking is observed over Europe and Asia, where the meridional gradient of θ is generally weak, whereas high-latitude blocking is mainly present over the oceans, to the north of the jet stream, where the meridional gradient of θ is much stronger. They occur on the equatorward and poleward flank of the jet stream, respectively, where the horizontal shear ∂u/∂y is positive in the first case and negative in the second case. A regional analysis is also conducted. Warm-cyclonic blocking over the Pacific and cold-anticyclonic blocking over Europe are identified as the most persistent types and are associated with large amplitude anomalies in temperature and precipitation. Finally, the high-latitude cyclonic events seem to correlate well with low-frequency modes of variability over the Pacific and Atlantic Oceans.
Southward Intertropical Convergence Zone Shifts and Implications for an Atmospheric Bipolar Seesaw
Authors: Cvijanovic Ivana , Langen Peter L. , Kaas Eigil , Ditlevsen Peter D. 
Published: January 2013

Abstract
In this study, southward intertropical convergence zone (ITCZ) shifts are investigated in three different scenarios: Northern Hemispheric cooling, Southern Hemispheric warming, and a bipolar seesaw-like forcing that combines the latter two. The experiments demonstrate the mutual effects that northern- and southern-high-latitude forcings exert on tropical precipitation, suggesting a time-scale-dependent dominance of northern versus southern forcings. In accordance with this, two-phase tropical precipitation shifts are suggested, involving a fast component dominated by the high-northern-latitude forcing and a slower component due to the southern-high-latitude forcing. The results may thus be useful for the future understanding and interpretation of high-resolution tropical paleoprecipitation proxies and their relation to high-latitude records (e.g., ice core data). The experiments also show that Southern Ocean warming has a global impact, affecting both the tropics and northern extratropics, as seen in a southward ITCZ shift and mid- and high-latitude North Atlantic surface temperature and wind changes. In terms of dynamical considerations, the tropical circulation response to high-latitude forcing is found to be nonlinear: the atmospheric heat transport and Hadley cell anomalies differ significantly (in magnitude) when comparing the warming and cooling experiments. These are related to different interhemispheric temperature gradients that are altered mainly by nonlinearities in water vapor response. Decomposition of the top-of-the-atmosphere flux response into atmospheric feedback effects shows the dominance of water vapor and cloud feedbacks in the tropics, with the longwave cloud feedback effect governing the overall cloud response.
Test of a Method for Monitoring the Geostrophic Meridional Overturning Circulation Using Only Boundary Measurements
Authors: Hughes Chris W. , Elipot Shane , Morales Maqueda Miguel Ángel , Loder John W. 
Published: January 2013

Abstract
Measurements of ocean bottom pressure, particularly on the continental slope, make an efficient means of monitoring large-scale integrals of the ocean circulation. However, direct pressure measurements are limited to monitoring relatively short time scales (compared to the deployment period) because of problems with sensor drift. Measurements are used from the northwest Atlantic continental slope, as part of the Rapid Climate Change (RAPID)–West Atlantic Variability Experiment, to demonstrate that the drift problem can be overcome by using near-boundary measurements of density and velocity to reconstruct bottom pressure differences with accuracy better than 1 cm of water (100 Pa). This accuracy permits the measurement of changes in the zonally integrated flow, below and relative to 1100 m, to an accuracy of 1 Sv (1 Sv ≡ 106 m3 s−1) or better. The technique employs the “stepping method,” a generalization of hydrostatic balance for sloping paths that uses geostrophic current measurements to reconstruct the horizontal component of the pressure gradient.
Electric Field Reversal in Sprite Electric Field Signature
Authors: Sonnenfeld Richard G. , Hager William W. 
Published: January 2013

Abstract
In measurements of the electric field associated with the current of a sprite 450 km from ground-based field sensors, it was observed that the sign of the electric field was positive when positive charge was lowered from the ionosphere. A recent model for the electric field associated with the sprite current also predicts positive field changes at 450 km from the sprite. A well-known analysis of a vertical dipole in a thundercloud shows that the electric field on the ground reverses its sign at an easily computed distance from the dipole. A similar simplified electrostatic analysis of a sprite predicts a field reversal distance around 130 km. A more accurate electrodynamic analysis based on Maxwell’s equations indicates that the field reversal distance should be between 70 and 80 km.
Comparison of Drop Jumps and Sport-Specific Sidestep Cutting
Authors: Kristianslund Eirik , Krosshaug Tron 
Published: January 2013

Background: Anterior cruciate ligament (ACL) injuries are a serious problem, with a high incidence and serious consequences. Published clinical screening tests are based on 2-legged and controlled drop jumps, but ACL injuries are known to occur in single-legged landings and sidestep cutting, where the load is predominantly distributed to a single leg. Purpose: To describe knee kinematics and kinetics in drop jumps and sidestep cutting and investigate the rank correlation of knee valgus angles and knee abduction moments between and within these movements. Study Design: Controlled laboratory study. Methods: A total of 120 elite female handball players (mean ± SD: age, 22.4 ± 7.1 years; height, 171 ± 7 cm; weight, 67 ± 7 kg), each performed 3 drop jumps and 3 sport-specific sidestep cuts to each side. Kinematics and kinetics were calculated from high-speed 3-dimensional motion analysis. Results: Knee kinematics and kinetics were significantly different between drop jumps and sidestep cutting. The knee abduction moment was 6 times higher in sidestep cutting (1.58 ± 0.60 Nm/kg vs 0.25 ± 0.16 Nm/kg). There was a poor correlation between knee abduction moments (ρ = 0.135) in the 2 tasks, but a moderate correlation (ρ = 0.706) for knee valgus angles. There was a poor correlation between knee valgus angles in drop jumps and knee abduction moments in sidestep cuts (ρ = 0.238). Conclusion: Motion patterns are different between drop jumps and sidestep cutting. There is a moderate correlation for knee abduction moments between the 2 tasks, but knee abduction moments are less consistent across tasks. Clinical Relevance: Knee valgus angles during drop jumps do not predict knee abduction moments during sidestep cutting. The moderate correlation of knee valgus angles in drop jumps and sidestep cutting indicates that this measure may be more relevant for screening efforts.
Effect of Simvastatin/Ezetimibe 10/10 mg Versus Simvastatin 40 mg on Serum Vitamin D Levels
Authors: Liberopoulos Evangelos N. , Makariou Stefania E. , Moutzouri Elisavet , Kostapanos Mixalis S. , Challa Anna , Elisaf Moses 
Published: January 2013

Backround: Low levels of 25-hydroxyvitamin D (25(OH)VitD) have been recognized as an emerging cardiovascular disease (CVD) risk factor. Statins are reported to increase 25(OH)VitD concentration. Animal studies suggest that ezetimibe is a moderate inhibitor of intestinal 25(OH)VitD absorption, but its effect in humans is unknown. Aim: To investigate whether combined treatment with simvastatin/ezetimibe 10/10 mg would increase 25(OH)VitD levels compared to simvastatin 40 mg monotherapy in patients with primary hypercholesterolemia. Methods: In a Prospective Randomized Open-label Blinded End point study, 50 patients with primary hypercholesterolemia received either simvastatin/ezetimibe 10/10 mg (n = 25) or simvastatin 40 mg (n = 25) daily for 3 months. The primary end point was between-group difference in the change of serum 25(OH)VitD levels. Results: Simvastatin/ezetimibe 10/10 mg was associated with a 36.7% increase in 25(OH)VitD serum levels (from 6.8 to 9.3 ng/mL, P = .000), while simvastatin 40 mg was associated with a 79.1% increase (from 6.7 to 12.0 ng/mL, P = .008). The increase in 25(OH)VitD levels in the simvastatin 40 mg group was significantly greater compared to that in the simvastatin/ezetimibe 10/10 mg group ( P = .04). Both groups exhibited similar reductions in low-density lipoprotein cholesterol (LDL-C) levels. Conclusion: For similar LDL-C lowering simvastatin 40 mg is associated with greater increase in 25(OH)VitD compared to simvastatin/ezetimibe 10/10 mg. Whether this difference is relevant in terms of CVD risk reduction is unknown.
Efficiency of Ankaferd Blood Stopper Used in Bleeding Control on Intraabdominal Adhesions Formed Postoperatively
Authors: Behçet AL , Kılıç Hasan , Zengin Suat , Güler Mehmet , Taysi Seyithan , Yıldırım Cuma , Sarı İbrahim 
Published: January 2013

Purpose: The purpose of this study is to investigate the hispathological, biochemical, and clinical efficiency of Ankaferd Blood Stopper (ABS) in preventing postoperative intraabdominal adhesions. Method: A total of 40 Wistar albino species female rats were randomly separated into 4 groups. For the control group, 1 mL normal saline was administered; and for the second, third, and fourth groups 0.5, 1, and 2 mL, respectively, ABS was administered. Statistical analyses were evaluated with Tukey and analysis of variance test. Findings: Significant increase was observed in fibroblast and vascularization microscopically with increasing amount of ABS used. Degree of adhesion in the group administered with normal saline was lower compared to the other groups. Adhesion thickness and prevalence macroscopically increased with the increasing amount of ABS used in groups. Conclusion: It was determined in our study that ABS is not efficient in preventing intraabdominal adhesions; on the contrary, adhesions were increased with the increased amount of ABS used.
Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice
Authors: Dovey Oliver M. , Foster Charles T. , Conte Nathalie , Edwards Sally A. , Edwards Jennifer M. , Singh Rajinder , Vassiliou George , Bradley Allan , Cowley Shaun M. 
Published: January 2013

Key PointsWe demonstrate a critical role for histone deacetylase 1 and 2 (HDAC1/2) in T-cell development and the maintenance of genomic stability.
Concurrent exposure to a dectin-1 agonist suppresses the Th2 response to epicutaneously introduced antigen in mice
Authors: Lin Jing-Yi , Chen Jau-Shiuh , Chen Pei-Chun , Chung Ming-Hui , Liu Ching-Yi , Miaw Shi-Chuen , Wang Li-Fang 
Published: January 2013

Abstract

Background
Epicutaneous sensitization with protein allergen that induces predominant Th2 responses is an important sensitization route in atopic dermatitis. Fungal components have been shown to modulate Th cell differentiation. However, the effects of fungal components on epicutaneous sensitization are unclear.

Results
In this study, we showed that co-administration of curdlan, a dectin-1 agonist, during epicutaneous ovalbumin sensitization of BALB/c mice decreased the IL-5 and IL-13 levels in supernatants of lymph node cell ovalbumin reactivation cultures. Mechanistically, curdlan co-administration decreased IL-4 and IL-1β expressions in draining lymph nodes. Curdlan co-administration also lower the migration of langerin+ CD103- epidermal Langerhans cells into draining lymph nodes at 96 hours post-sensitization which might be attributed to decreased expressions of IL-18 and IL-1β in patched skin. Moreover, adoptive transfer of CFSE-labeled transgenic CD4 T cells confirmed that curdlan co-administration decreased the proliferation and IL-4-production of ovalbumin -specific T cells primed by epidermal Langerhans cells.

Conclusions
These results indicated that concurrent exposure to a dectin-1 agonist suppresses the epicutaneously induced Th2 response by modulating the cytokine expression profiles in draining LNs and the migration of epidermal Langerhans cells. These results highlight the effects of fungal components on epicutaneous allergen sensitization in atopic diseases.
Prospective cohort study of HIV incidence and molecular characteristics of HIV among men who have sex with men(MSM) in Yunnan Province, China
Authors: Xu Junjie , An Minghui , Han Xiaoxu , Jia Manhong , Ma Yanling , Zhang Min , Hu Qinghai , Chu Zhenxing , Zhang Jing , Jiang Yongjun , Geng Wenqing , Lu Lin , Shang Hong 
Published: January 2013

Abstract

Background
Yunnan has the largest number of reported HIV/AIDS cases among all Chinese provinces, the reported prevalence of HIV among Yunnan men who have sex with men (MSM) passed 10%, while HIV incidence epidemic and molecular characteristics of new infected Yunnan MSM were not evaluated before.

Methods
An 18 months prospective followed up with a frequency of 3 month per visit were conducted among HIV seronegative MSM in Kunming cityduring 2009–2011. Interviewer-administrated questionnaires were carried out. Blood specimens were obtained to test for syphilis and HIV, in which HIV were evaluated by standard HIV enzyme immunoassay (EIA) and HIV nucleic acid amplification testing (NAAT). Near full-length regions of the HIV-1 were evaluated for subtyping, primary drug resistance mutations.

Results
During the follow-up 70.1% of the recruited 378 MSM retained in the cohort. Eleven MSM seroconverted to HIV and fifteen MSM seroconverted to syphilis. The HIV incidence and syphilis incidence was 3.5 (95% CI 1.8-6.2) cases /100 person year(PY) and 5.3 (95% CI 3.0-8.7) cases/100 PY, respectively. Multivariate analysis showed that baseline syphilis infection (aHR, 17.7), occupation (students vs. others [aHR, 5.7], retirees vs. others [aHR, 4.1]), bleeding experience after receptive anal intercourse (aHR,7.6), and minority ethnic(vs. Han) [aHR, 5.7] were independent risk factors for HIV seroconversion(each P<0.05). Among the 7/11 successfully amplified near full-length sequences, 71.4% (5/7) were CRF01_AE, and 28.6% (2/7) were CRF07_BC. Two HIV transmission pairs were detected among seroconverted minority ethnic MSM.

Conclusions
HIV incidence was moderately high among Yunnan MSM. Yunnan province need to strengthen both HIV and syphilis screening among MSM population. Some subpopulations of MSM, such as students, retirees and minority ethnic groups require more HIV epidemic surveillance and strengthened behavior interventions. HIV subtypes and primary drug resistance should be continually monitored to track cross-group transmission of HIV strains.
A successful antimicrobial regime for Chromobacterium violaceum induced bacteremia
Authors: Campbell James I , Lan Nguyen Phu Huong , Qui Phan Tu , Dung Le Thi , Farrar Jeremy J , Baker Stephen 
Published: January 2013

Abstract

Background

Chromobacterium violaceum is a proteobacterium found in soil and water in tropical regions. The organism rarely causes infection in humans, yet can cause a severe systemic infection by entering the bloodstream via an open wound.

Case presentation
We recently identified a case of severe bacteremia caused by Chromobacterium violaceum at the Hospital for Tropical Diseases (HTD) in Ho Chi Minh City, Vietnam. Here, we describe how rapid microbiological identification and a combination of antimicrobials was used to successfully treat this life threatening infection in a four-year-old child.

Conclusions
This case shows the need for rapid diagnosis when there is the suspicion of a puncture wound contaminated with water and soil in tropical regions. We suggest that the aggressive antimicrobial combination used here is considered when this infection is suspected.
Value of digital telethermography for the diagnosis of septic knee prosthesis: a prospective cohort study
Authors: Romanò Carlo Luca , D’Anchise Roberto , Calamita Marco , Manzi Giovanni , Romanò Delia , Sansone Valerio 
Published: January 2013

Abstract

Background
Diagnosis of peri-prosthetic infection remains challenging, often requiring a combination of different tests.

Methods
In this prospective, case–control study, the diagnostic accuracy of telethermography was evaluated in a group of seventy patients who had had a total knee replacement and were undergoing a reoperation because of infection or another implant-related problem, after a minimum of one year from implant.

Results
An average differential temperature of the affected versus not affected knee of 1.9°C was observed in infected prosthesis, compared to 0.3°C in aseptic failures. Considering a normal reference value equal or less than 1.0°C, telethermography showed an accuracy, sensitivity, specificity, positive and negative predictive value of, respectively: 0.90, 0.89, 0.91, 0.91, 0.88.

Conclusions
Digital telethermography is a reliable option for diagnosing peri-prosthetic knee infection.