bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between perceived stress and asthma symptoms among public universities students in Riyadh, Saudi Arabia
Authors: Almeshari Mohammed A. , Bahashwan Lujain , Alomran Dalal , alzahrani Leen , Alomair Hailah , Alassaf Ghaida , Alanazi Abdullah M. 
Published: February 2025

Abstract

Background
Asthma is a chronic inflammatory disease characterized by recurrent and fluctuating airflow limitations. The objective of the study was to assess the association between stress and asthma symptoms among students enrolled at public universities in Riyadh, Saudi Arabia.

Methodology
A cross-sectional study was conducted, utilizing the Arabic-validated questionnaires of the asthma control test (ACT), the Perceived Stress Scale (PSS), and the European Community Respiratory Health Survey (ECRHS) as the primary instrument for data collection. Statistical analysis was performed using RStudio software. Appropriate ethical guidelines were followed throughout the research process.

Results
The study included 156 public university students in Riyadh, Saudi Arabia. The participants were predominantly female (84.0%) with a median age of 21 years. Using PSS, 3.2% had low, 80.1% had moderate, and 16.6% had high perceived stress levels. In total, 127 participants (81.4%) reported experiencing respiratory symptoms. After adjusting for age, sex, BMI, and smoking status, students with high perceived stress were found to be more likely to report respiratory symptoms compared to those with moderate stress (OR: 6.85, 95% CI 1.20–130.0). This demonstrated a significant association between increased stress and asthma related symptoms.

Conclusion
High perceived stress levels were associated with respiratory symptoms. These findings should be utilized to build strategies for improving the management and control of asthma symptoms in this population.
Factors influencing anticipated migration patterns across metropolitan cities in the United States between 2018 and 2022
Authors: Gude Vinayaka , Melendez Ricardo , Islam Md Monirul 
Published: February 2025

Abstract
The COVID-19 pandemic has impacted people’s lives in various cities across the United States. This study explored the factors influencing anticipated migration patterns as indicated by the house search on the Redfin platform in 132 United States cities before, during, and after the COVID-19 Pandemic. The research addresses a crucial gap in the existing literature on recent trends in migration patterns, factors influencing this, and the potential impact of the pandemic. We employed a multivariate regression model to study overall migration and additional models to examine yearly data, identifying key factors that drive people to relocate. We identified that regions with better healthcare services, lower income inequality, and lower unemployment rates increasingly attract residents. Cities with greater racial and ethnic diversity, as well as high school completion rates, were also appealing until 2020 when the importance of education in migration decisions was overshadowed by housing affordability issues. Meanwhile, proximity to larger cities played a significant role, with people favoring smaller cities nearby for better growth opportunities. Our findings suggest that developing cities with smaller populations are becoming preferred destinations due to their mix of affordability, job opportunities, and better living conditions. These insights are invaluable for policymakers, city planners, and community organizations, helping guide urban development strategies and address challenges such as income inequality, neighborhood segregation, and healthcare accessibility.
Can access to restaurant meals under the Supplemental Nutrition Assistance Program lead to obesity?
Authors: Jamal Ayesha 
Published: February 2025

Abstract
Supplemental Nutrition Assistance Program (SNAP) makes an exception to its rules, which allows elderly and/or disabled individuals, their spouses, as well as homeless beneficiaries, to buy hot prepared food from restaurants if they live in a state that participates in the Restaurant Meals Program (RMP). Using the staggered countywide adoption timeline in California, coupled with a stacked difference-in-differences empirical strategy, I examine the intent-to-treat (ITT) nutritional effects of RMP on the elderly population. Overall, I find no evidence that obesity rates for the elderly are any different in counties with RMP versus those without RMP. I can statistically rule out moderate effects. Additional evidence from some of the early-adopting counties suggests that RMP is associated with a reduction in food insecurity among the elderly.
A Tale of Four Crises: The European Court of Justice’s Response to Crises
Authors: Constantinou Eftychia 
Published: February 2025

Abstract
While the European Union was recently affected by four major and multifaceted crises which gave rise to litigation, the response of the European Court of Justice to these events has remained understudied. From a close reading of the procedural features, the legal reasoning and timing of four key judgments concerning measures adopted in the wake of the Eurozone crisis, the migration crisis, Brexit, and the COVID-19 pandemic, this article sketches a broader narrative about the Court’s response to crises which transcends the specificities of the legal issues and the context of each case. The findings suggest that the Court is likely to adjudicate a crisis case by applying the expedited procedure depending on political developments, assign a larger chamber, carefully justify its reasoning with references to settled case-law, conduct a context-sensitive balancing exercise, and deliver a decision at a politically relevant time.
On a perturbed critical semilinear equation with singularity
Authors: Goyal Sarika , Sandeep Kunnath 
Published: February 2025

Abstract
In this article, we investigate necessary and sufficient conditions on the perturbation ρ for the existence of positive least energy solutions of the critical singular semilinear elliptic equation

$ -\Delta u = \frac{|u|^{2^{*}(s)-2}}{|x|^s}u + \rho(u) $

with Dirichlet boundary condition in a bounded smooth domain in

$\mathbb R^n$

containing the origin, where

$2^*(s)=\frac{2(n-s)}{n-2}$

,

$0\leq s \lt 2 \lt n$

. We show that the almost necessary and sufficient condition obtained for the case s = 0 in [1] differs conceptually when

$0 \lt s \lt 2$

.
The preservation potential of loess in low-elevation mountains (Mecsek Mountains, Hungary)
Authors: Sebe Krisztina , Józsa Sándor , Lukács Réka , Surányi Gergely , Harangi Szabolcs , Novothny Ágnes 
Published: February 2025

Abstract
Loess–paleosol outcrops were logged and dated to trace loess cover during the Pleistocene in a low-elevation mountainous area. The exposed successions were a maximum of 15 m thick and stratigraphically fragmentary. Still, results suggest that loess was deposited in all climatically suitable periods within the limits of the dating methods (ca. 400 ka), and probably also beyond this. Luminescence measurements provided numerical ages from ca. 18 ka to ca. 200 ka and minimum ages of up to >267 ka. Loess accumulation was also active during the relatively mild MIS 3. A new occurrence of a well-preserved Quaternary tephra was documented, correlative with the middle Pleistocene Bag Tephra (ca. 340 or 368 ka). The dating of loess successions provided valuable data on geomorphic evolution as well, identifying hydrological changes and constraining a maximum incision and uplift rate of 0.008–0.035 mm/yr for the western part of the area. The low thickness of loess–paleosol successions and the stratigraphic gaps seem to be a consequence of repeated erosion during the Pleistocene rather than a result of non-deposition. The mountains probably have been covered with loess for most of the time during the past 1 Ma. This should be taken into consideration in studies influenced by the loess cover of an area.
Distribution of exchangeable arsenic in low-land paddy fields in Sri Lanka as affected by the agro-climatic zone, soil and water source
Authors: Neththasinghe Anuththara , Thennakoon Nipuna , Dissanayaka Samantha , Marambe Buddhi , Kadupitiya Harsha , Rathnayake Upul , Chandrajith Rohana , Suriyagoda Lalith 
Published: February 2025

Abstract
The presence of excessive arsenic (As) in paddy fields poses a significant risk to human health due to its accumulation in rice grains. However, the current level of As in Sri Lankan paddy fields remains unclear. Therefore, this research aims to assess the distribution of exchangeable As concentration and investigate the effects of agro-climatic zones (ACZs), soil orders, and water sources on exchangeable As concentration in Sri Lankan paddy fields. For this purpose, 7,154 soil samples were collected from paddy fields using a stratified random sampling method representing six ACZs, six soil orders, and three water sources. Arsenic extraction was made using 0.01 M CaCl2 followed by the detection with Inductive Coupled Plasma Mass-Spectrophotometry. The concentration of exchangeable As ranged from 0.01 to 392.9 µg/kg with an average of 24.6 µg/kg. Samples from the Low-country Wet zone exhibited higher exchangeable As levels compared to those from the Low country Dry zone (p<0.05). Among soil orders, Histosols, Inceptisols, and Ultisols showed higher exchangeable As concentrations than Alfisols and Vertisols (p<0.05). Rainfed paddy fields had higher exchangeable As compared to the fields with access to supplementary irrigation. Additionally, exchangeable As concentration was inversely correlated with soil pH and paddy grain yield (p<0.05). The observed variations in soil-As concentration across ACZs, soil orders, and water sources highlight the need for climate, soil order, and water source-specific strategies to mitigate further accumulation of As in paddy fields.
Plant diversity drives sandy-loam soil quality and crop yields in integrated crop-livestock systems
Authors: Gonçalves Evelyn Custódio , Silva Laércio Santos , de Camargo Tatiane Andrea , Nogueira Bruna Karolayne Andrade , Dalla Côrt Andressa Selestina , Ponce Polyana Freitas , Pires Gabriela Castro , Silva Izabela Aline Gomes da , Pacheco Leandro Pereira , Tadini Amanda Maria , Martin-Neto Ladislau , de Moraes Anibal , Carvalho Paulo César de Faccio , de Souza Edicarlos Damacena 
Published: February 2025

Abstract
Agricultural monoculture negatively impacts soil quality, particularly in fragile soils that yield limited crop production and are highly susceptible to degradation. Increasing plant diversity in production systems can be an alternative for maintaining soil ecosystem services and increasing crop yields. This study investigated the influence of increased plant diversity on soil health and its impact on soybean and cotton yield in an Ultisol in the Brazilian savanna in Mato Grosso State, Brazil. Tested five levels of plant diversity after soybean harvest: 1) very low (VL), 2) low (LW), 3) average (AVG), 4) long term average (AVL) e 5) high (ICLS) were tested. Plant diversity improves the health of sandy loam soil, increases C and N fractions in particulate organic matter (POM-C and POM-N) and leads to differences in C utilization by the soil microbial community. High ICLS diversity raises total organic carbon levels (TC, being POM-C and POM-N, the labile fractions, more efficient to show changes in sandy loam soil, in the short term, over a period of three years. High diversity promoted yield gains of up to 251% for cotton and 82% for soybean in relation to very low plant diversity. Changes in soil microbial composition are able to partially explain crop yield in diversified production systems (R2 ranging from 0.51 to 0.80). Diversifying production components is a sustainable way to maintain biological functions and agricultural quality of loam sandy soil in the Brazilian Cerrado in Mato Grosso.
Feasibility of Measuring Physical Function by Wearable Devices During Deprescribing of Anticholinergic and Sedative Medicatiossns
Authors: Cossette Benoit , Boissy Patrick , Milot Marie-Hélène , Hilmer Sarah N , Kouladjian O’donnell Lisa , Gnjidic Danijela , Sirois Caroline , Mangin Dee , Ricard Geneviève , Isenor Jennifer E. , Roy-Petit Jacynthe , Abdulrazak Bessam , Tousignant Marilyn , Lebel Karina 
Published: February 2025

Abstract
Cumulative exposure to anticholinergic and sedative medications has been associated with worsening physical function in older adults. We evaluated the feasibility of measuring physical function using wearable devices and explored the impact of reducing the anticholinergic and sedative medication burden in a pilot study of community-dwelling adults aged 60 years and older. Evaluations included the 10-meter walk test (10MWT), the Short Physical Performance Battery (SPPB), and the mini-BESTest. Two participants/month were recruited in one clinic in 2022. The five participants had a median age of 67, a median DBI of 1.7, and four were female. The feasibility analysis showed that the 10MWT and SPPB tests were completed on 12/12, and the mini-BESTest on 11/12. An exploratory analysis showed clinically meaningful improvements in gait speed (mean +0.18 m/s) and SPPB (mean +2.2 points). We showed the feasibility of measuring physical function by wearable devices during deprescribing of anticholinergic and sedative medications.
Kant on Imperfect Duties: A Defence of the Latitudinal Interpretation
Authors: Galvin Richard 
Published: February 2025

Abstract
According to the ‘rigorist’ interpretation, the imperfect duty of (e.g.) beneficence does not permit agents to fail to perform any beneficent act that is available to the agent in order to pursue some nonmoral interest, whereas on the latitudinal interpretation, agents are permitted to fail to do so. I defend the latitudinal interpretation by criticising recent defences of rigorism offered by Jens Timmermann and Pauline Kleingeld, arguing that they conflict with important features of Kant’s moral theory, and that the latitudinal interpretation better coheres with Kant’s overall view.
Dynamics of the 2021 Fagradalsfjall Eruption (Iceland) Revealed by Volcanic Tremor Patterns
Authors: Soubestre Jean , Caudron Corentin , Melnik Oleg , Lecocq Thomas , Jaupart Claude , Shapiro Nikolai M. , Journeau Cyril , Çubuk‐Sabuncu Yeşim , Jónsdóttir Kristín 
Published: February 2025

AbstractCo‐eruptive volcanic tremor during the 2021 Fagradalsfjall eruption in Iceland (19 March–18 September 2021) is characterized using seismic and visual data recorded close to the eruption site and across the Reykjanes Peninsula. An automatic seismic network‐based approach reveals several tremor patterns associated with seven phases of the eruption, including (a) continuous tremor located beneath the eruption site and attributed to pressure changes in the shallow vent system(s) in phases I, III, and VII, and (b) two patterns of minute‐ and hour‐long intermittent tremor in May (phase II) and July–August (phases IV–VI), respectively. The first intermittent pattern of minute‐long tremor bursts associated with pulsating lava fountains in May is attributed to magma degassing in a shallow reservoir (top 100 m) connected to a top‐conduit. The progressive enlargement of both the top‐conduit and shallow reservoir with time is estimated quantitatively using a collapsing foam model. Sudden changes of their geometries, as detected from tremor characteristics, are systematically associated with observed crater collapse events. The second intermittent pattern of cyclic hour‐long tremor episodes associated with episodic effusive activity in July–August is attributed to magma flowing and cooling in the feeder dike connected to a sill at 5 km depth. The sill is fed by a constant influx of magma from the deeper plumbing system and stores magma during low discharge periods. The observed cyclicity of both the eruptive activity and the tremor is interpreted quantitatively with a sill‐dike model accounting for magma cooling and induced cyclic viscosity changes in the dike.
Photon-triggered pyroptosis and ferroptosis dual-functional nanoplatform for cancer immunotherapy
Authors: Cheng Quansheng , Wang Qingcheng , Qu Songnan 
Published: February 2025

Abstract
A dual-functional nanoplatform is demonstrated that is found to have the characteristics of cancer cell targeting, pH response, near-infrared fluorescence imaging, and lysosome targeting. It can simultaneously achieve pyroptosis and ferroptosis under the mediation of photons for cancer immunotherapy.
Toolkit for integrating millimeter-sized microfluidic biomedical devices with multiple membranes and electrodes
Authors: Tao Xudong , Naegele Tobias E. , Rognin Etienne , Willis-Fox Niamh , Oldroyd Poppy , Dong Chaoqun , Kissovsky Stefany , Dominguez-Alfaro Antonio , Velasco-Bosom Santiago , Daly Ronan , Malliaras George G. 
Published: February 2025

Abstract
In recent years, microfluidic systems have evolved to incorporate increasingly complex multi-layer and multi-material structures. While conventional 2-dimensional microfluidic systems are typically fabricated with lithographic techniques, the increase in system complexity necessitates a more versatile set of fabrication techniques. Similarly, although 3D printing can easily produce intricate microfluidic geometries, integrating multiple membranes and electrode components remains challenging. This study proposes a toolkit for fabricating free-standing 3-dimensional microfluidic systems for biomedical devices, incorporating flow channels, electrodes, and membranes. The fabrication techniques include molding separation using 3D printed molds, laser-based processing, and component assembly, each achieving micron resolution. Here, we introduce a novel approach to integrate membranes into microfluidics by directly curing elastomer-based microfluidics with the membrane through replica molding, while preserving membrane functionality by effectively removing elastomer residues through reactive ion etching. The resulting membrane-elastomer microfluidic component significantly simplifies the assembly of intricate microfluidic systems, reducing the device size to millimeter dimensions, suitable for implantable applications. The toolkit’s versatility is demonstrated by a redox flow iontophoretic drug delivery prototype at the millimeter scale, featuring two electrodes, four membranes, and four microfluidic channels.
Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial
Authors: Ruan Dan-Yun , Huang Wen-Wen , Li Yongsheng , Zhao Yanqiu , Shi Yehui , Jia Yuming , Cang Shundong , Zhang Wei , Shi Jianhua , Chen Jun , Lin Jie , Liu Yunpeng , Xu Jianming , Ouyang Weiwei , Fang Jian , Zhuang Wu , Liu Caigang , Bu Qing , Li Manxiang , Meng Xiangjiao , Sun Meili , Yang Nong , Dong Xiaorong , Pan Yueyin , Li Xingya , Qu Xiujuan , Zhang Tongmei , Yuan Xianglin , Hu Sheng , Guo Wei , Li Yalun , Li Shengqing , Liu Dongying , Song Feixue , Tan Liping , Yu Yan , Yu Xinmin , Zang Aimin , Sun Chang , Zhang Qian , Zou Kai , Dan Mo , Xu Rui-Hua , Zhao Hongyun 
Published: February 2025

Abstract
HA121-28, a promising multikinase inhibitor, mainly targets rearranged during transfection (RET) fusions and selectively targets vascular endothelial growth factor receptor-2, endothelial growth factor receptor, and fibroblast growth factor receptor 1-3. The safety, pharmacokinetics, and efficacy of HA121-28 were assessed in advanced solid tumors (phase 1, ClinicalTrials.gov NCT03994484) and advanced RET fusion-positive non-small-cell lung cancer (RET-TKI naive NSCLC, phase 2, ClinicalTrials.gov NCT05117658). HA121-28 was administered orally in doses range from 25 to 800 mg under the 21-day on/7-day off scheme for a 28-day cycle in phase 1 trial. The recommended dose identified in phase 1 (450 mg) was administered for patients during phase 2. The primary endpoints were the maximum tolerated dose (MTD) in phase 1 and the objective response rate (ORR) in phase 2. 162 patients were enrolled in phase 1 and 48 in phase 2. A total of 600 mg once daily was set as MTD. Across 100–800 mg, the exposure of HA121-28 increased in a dose-dependent manner. Consistent between both trials, diarrhea, rash, and prolonged QTc interval, were the most reported treatment-emergent adverse events. 40.0% (phase 1) and 62.5% (phase 2) patients experienced grade ≥3 treatment-related adverse events, respectively. The overall ORR was 26.8% and the median progression-free survival (PFS) was 5.5 months among 97 NSCLC patients with advanced RET fusion receiving a dose at ≥450 mg once daily. HA121-28 showed encouraging efficacy in advanced RET fusion NSCLC and its toxicity was tolerable in most patients. Nevertheless, cardiotoxicity is a notable concern that warrants careful attention.
Association between climate related hazards and depression among coastal communities in Indonesia
Authors: Maharani Asri , Sujarwoto Sujarwoto , Susanti Herni , Brooks Helen , Bee Penny 
Published: February 2025

Abstract
Climate change has a profound impact on the mental health and well-being of people all over the world. However, studies on the impacts of climate-driven rising sea levels on mental health remain few. This study aims to examine the risk of depression among people who live in coastal areas susceptible to the natural hazards associated with climate change. We used the Indonesia Basic Health Survey 2018, which included 642,419 adults in Indonesia. Multivariable logistic regression analysis was conducted to examine the relationship between living in a coastal hazard area and depression. We included socio-demographics, health status, and health access information in the analysis to identify the most vulnerable groups. Our findings show that people who live in coastline hazard areas have 1.13 times higher odds to have depression than people who live outside those areas. Individuals living in the coastal hazards areas who were less likely to have autonomous mobility or resources, including young adults, females, those with low socio-economic conditions, and those with pre-existing health conditions, had a higher risk of depression than other groups. Culturally acceptable and effective mental health interventions should thus target these vulnerable populations and settings to effectively reduce climate-related health risks.
Proteomic insights into survival strategies of Escherichia coli in perchlorate-rich Martian brines
Authors: Kloss Lea D. F. , Doellinger Joerg , Gries Anne , Soler Elisa , Lasch Peter , Heinz Jacob 
Published: February 2025

Abstract
Brines, potentially formed by the deliquescence and freezing point depression of highly hygroscopic salts, such as perchlorates (ClO4
−), may allow for the spatial and temporal stability of liquid water on present-day Mars. It is therefore of great interest to explore the microbial habitability of Martian brines, for which our current understanding is, however, still limited. Putative microbes growing in the perchlorate-rich Martian regolith may be harmed due to the induction of various stressors including osmotic, chaotropic, and oxidative stress. We adapted the model organism Escherichia coli to increasing sodium perchlorate concentrations and used a proteomic approach to characterize the adaptive phenotype. Separately, the microbe was adapted to elevated concentrations of sodium chloride and glycerol, which enabled us to distinguish perchlorate-specific adaptation mechanisms from those in response to osmotic, ion and water activity stress. We found that the perchlorate-specific stress response focused on pathways alleviating damage to nucleic acids, presumably caused by increased chaotropic and/or oxidative stress. The significant enrichments that have been found include DNA repair, RNA methylation and de novo inosine monophosphate (IMP) biosynthesis. Our study provides insights into the adaptive mechanisms necessary for microorganisms to survive under perchlorate stress, with implications for understanding the habitability of Martian brines.