bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of IL13 polymorphisms with susceptibility to myocardial infarction: A case-control study in Chinese population
Authors: Chen Rong , Bao Qiaoling , Ma Xiaofeng 
Published: August 2024

Background
Inflammatory cytokines play a major role in the pathogenesis of myocardial infarction (MI). Although information on the importance of interleukin 13 (IL13) in human MI is limited, it has been well documented in the mouse model. Genetic variation in the IL13 gene has been associated with the structure and expression of the IL13. In the present study, we hypothesized that IL13 common genetic variants would be associated with a predisposition to the development of MI.

Materials and methods
The present study enrolled 305 MI patients and 310 matched healthy controls. Common genetic polymorphisms in the IL13 gene (rs20541, rs1881457, and rs1800925) were genotyped using the TaqMan SNP genotyping method. Plasma levels of IL13 were measured using an enzyme-linked immunosorbent assay (ELISA).

Results
In MI patients, minor alleles of the IL13 rs1881457 and rs1800925 polymorphisms were less common than in healthy controls [rs1881457: AC (P = 0.004, OR = 0.61), C (P = 0.001, OR = 0.66); rs1800925: CT (P = 0.006, OR = 0.59)]. Further haplotype analysis of three studied SNPs revealed a significant association with predisposition to MI. Interestingly, IL13 rs1881457 and rs1800925 were linked to plasma levels of IL13: the reference genotype had higher levels, heterozygotes were intermediate, and the alternate genotype had the lowest levels.

Conclusions
In the Chinese population, IL13 (rs1881457 and rs180092) variants are associated with different plasma IL13 levels and offer protection against MI development. However, additional research is required to validate our findings in different populations, including descent samples.
Nuevas configuraciones del derecho a pensión en Argentina
Authors: Cóceres Celeste 
Published: August 2024

El presente trabajo analiza las pensiones en el derecho previsional argentino, prestaciones de la seguridad social que brindan cobertura frente a la contingencia social de desamparo por muerte. En particular, realiza un recorrido por su surgimiento, su finalidad originaria, y las modificaciones que fue acompañando la agenda pública, conforme variaron las circunstancias socioculturales. En este devenir se destacan las reformas legislativas y su ampliación por vía jurisprudencial, ante nuevos presupuestos susceptibles de tutela. Asimismo, se plantea la ineludible revisión de los supuestos, que garanticen la cobertura social frente a las necesidades económicas que genera la contingencia muerte, en equilibrio con la sustentabilidad del sistema y sin perder el foco del fundamento de esta institución.
Modern Perspectives on Hypertrophic Cardiomyopathy—No One Size Fits All
Authors: Doliner Brett , Gaddar Hadeel , Kalil Ramsey , Postalian Alexander 
Published: August 2024

Abstract
Despite substantial advances in the management of hypertrophic cardiomyopathy, advanced heart failure remains a major cause of morbidity in this patient population. This narrative review presents the case of a patient with hypertrophic obstructive cardiomyopathy who underwent alcohol septal ablation to frame a discussion of modern therapies for hypertrophic cardiomyopathy. The current treatment landscape includes medications, both old and new, and surgical and procedural interventions to relieve mechanical obstruction.
Several promising new modalities for relieving obstruction are in the nascent stages of development.
The TOM complex from an evolutionary perspective and the functions of TOMM70
Authors: Özdemir Metin , Dennerlein Sven 
Published: August 2024

Abstract
In humans, up to 1,500 mitochondrial precursor proteins are synthesized at cytosolic ribosomes and must be imported into the organelle. This is not only essential for mitochondrial but also for many cytosolic functions. The majority of mitochondrial precursor proteins are imported over the translocase of the outer membrane (TOM). In recent years, high-resolution structure analyses from different organisms shed light on the composition and arrangement of the TOM complex. Although significant similarities have been found, differences were also observed, which have been favored during evolution and could reflect the manifold functions of TOM with cellular signaling and its response to altered metabolic situations. A key component within these regulatory mechanisms is TOMM70, which is involved in protein import, forms contacts to the ER and the nucleus, but is also involved in cellular defense mechanisms during infections.
Quality of outcome (QoO) in oral cancer patients: prospective perioperative analysis of patients’ resilience and satisfaction during inpatient stay at a University Medical Centre in Germany
Authors: Kröplin Juliane , Reppenhagen Jil-Charlot , Hirsemann Anke , Liese Jan , Frerich Bernhard 
Published: August 2024

Abstract

Objectives
Quality assurance strategies for head and neck surgery can improve patient outcomes. This study aims a perioperative analysis of indicators in the quality of outcome in oral cancer patients with special focus on patient`s resilience and satisfaction before and after surgery.

Methods
Patients with oral cancer (OCP) and indication for surgical resection were included in a prospective study. General and disease-related data as well as parameters of patient-specific resilience (RS-11 questionnaire) and physical strength (ECOG-Score) were collected. Importance and satisfaction using the nine items family/friends, sports activities/physiotherapy, participation in culture, professional perspectives, sexuality, enjoyable food, external appearance, social recognition and independence were analysed. The data collection took place pre- and postoperatively (mean: 10th postop day) during the inpatient stay.

Results
Twenty-eight patients with oral cancer (OCP) were analysed (male: n=23, female n=5). The rate of R0 resections was 92.6 %. The average length of stay was 21 days. n=16 of all patients was tracheotomised postop (preop: n=0). n=0 patients confirmed psycho(onco)logical support preop (postop: n=19). Sports activities/physiotherapy was provided to n=3 patients preop (postop: n=21). The mean pre and postop pain perception was 3/10. The RS-11 score decreased significantly postoperatively (p=0.01). A significant loss of satisfaction was seen in the areas of enjoyable food (p<0.001), social recognition (p=0.01), external appearance (p=0.01) and independence (p<0.001).

Conclusions
Supportive therapy measures to promote mental and physical fitness of oral cancer patients are part of inpatient care at our clinic. However, there is no standardised monitoring of these therapies. Digitally supported and standardised programmes to increase mental and physical fitness in both prehospital and inpatient care might lead to an improvement in the quality of outcome despite shortage of resources in terms of time, costs and personnel. A minimally invasive approach to tracheal cannula management and lymph node management in the treatment of OCP can help to reduce the length of stay in the intensive care unit.
Ambivalent Utopias: Corporate Biopower and the Gendered Limits of Agency in Reset
Authors: Lei Jun 
Published: August 2024

Abstract
This article examines Reset (逆时营救, 2017), a Chinese science fiction film that diverges from the genre’s typical patriotic themes. Reset offers a compelling case study for exploring technoscience’s impact – as a tool of corporate biopower and neocolonialism – on human corporeality, subjectivity, and female agency. The film’s protagonist, Xia Tian, transforms from a career-focused scientist to time-traveling cyborgs, ultimately reverting to a traditional maternal role. Analyzing this trajectory through Foucault’s biopower, Haraway’s cyborg feminism, and contemporary theories on reproductive futurism and sacrificial motherhood, the study unveils Reset’s function as an allegorical lens. It magnifies the effects of global corporate biopower on human subjectivity, particularly female agency amid apocalyptic upheavals. Xia Tian’s journey illustrates the complexities professional women face in balancing career and family, reflecting broader societal issues and mirroring Chinese cultural imperatives that simultaneously valorize motherhood and women’s workforce participation. Reset performs a double movement: introducing alternative forms of womanhood via cyborg iterations while framing these as incompatible with the envisaged societal future. This paradox highlights the film’s ambiguous stance, critiquing neocolonial capitalism’s manipulation of human bodies while exhibiting a conservative approach to gender roles.
Perceived quality of a nighttime hospital soundscape
Authors: Lenzi Sara , Lindborg PerMagnus , Spagnol Simone , Kamphuis Daan , Özcan Elif 
Published: August 2024

Abstract
The hospital soundscape is known for high noise levels and a perception of chaos, leading to concerns about its impact on patients, families, professionals, and other hospital staff. This study investigates the relationship between sound, Annoyance, and sleep quality in a multi-patient neurology ward. A mixed-methods approach was employed. Interviews were conducted with medical staff (n = 7) to understand their experiences with sound. Questionnaires and sleep tracking devices (n = 20) assessed patient sleep quality and Annoyance caused by sound events. In addition, listeners (n = 28) annotated 429 nighttime audio recordings to identify sound sources and rate Annoyance level, which we considered the key emotional descriptor for patients. Over 9,200 sound events were analysed. While snoring, a patient-generated sound dominated the nighttime soundscape and was highly rated for Annoyance, and staff-generated sounds such as speech and footsteps were found to contribute more to accumulated Annoyance due to their extended duration. This study suggests that patient sleep quality can be improved by focusing on design interventions that reduce the impact of specific sounds. These might include raising awareness among staff about activities that might produce annoying sounds and implementing strategies to mitigate their disruptive effects.
Parameter optimization for ultrasonic-assisted grinding of γ-TiAl intermetallics: A gray relational analysis approach with surface integrity evaluation
Authors: Yang Song , Zhang Guangjin , Xiao Guoqing 
Published: August 2024

Abstract
The processing of γ-TiAl intermetallic compound (Ti–45Al–2Mn–2Nb) is essential for manufacturing aircraft engine components, known for their challenging machinability. This study delved into the machining performance of γ-TiAl intermetallic compound through ultrasonically assisted grinding experiments. Various grinding parameters, such as wheel rotation speed (v
s), feed rate (v
w), depth of grinding (a
p), and ultrasonic amplitude (A), were investigated to understand their effects on grinding forces, temperatures, and surface quality. Gray relational analysis (GRA) and analysis of variance were used to analyze experimental data and ascertain the optimal machining parameters for ultrasonically assisted grinding of γ-TiAl intermetallic compound. Additionally, post-processing surface integrity, encompassing surface roughness, morphology, and residual stresses, was evaluated. The optimal grinding parameter combination was determined as F
n = 3.22 N, F
t = 1.08 N, and T = 174°C through GRA. Under the selected machining conditions, the depth of cut exerted the most significant influence on the grinding force and temperature, while the effect of wheel speed was the weakest. The surface roughness (Ra) of the workpiece increased with increasing feed rate and depth of the cut but decreased gradually with increasing wheel speed. Upon applying ultrasonic vibration, there was a notable decrease in surface roughness, ranging from 20.12 to 7.67%. However, the increase in the wheel speed, depth of cut, and feed rate inhibited the reduction of roughness due to ultrasonic vibration. Ultrasonic vibration effectively reduced the profile height of the workpiece surface, with a maximum reduction of 1.94 μm within the selected range. Nonetheless, as the wheel speed, depth of cut, and feed rate increased, the effectiveness of this reduction gradually diminished.
„Die ukrainische Sprache klingt so melodisch, so wohltönig wie der Gesang einer Nachtigall“
Authors: Rothstein Björn , Firstein Angelina , Koczy Joana , Sylejmani Lena , Ivanytska Maria , Materynska Olena 
Published: August 2024

Summary
How do you find and justify your favorite word? What types of metalinguistic activities do speakers use and how do they compare their favorite word with other words? And above all: What significance does it have and must it have when one’s own language and culture are in danger? In the summer of 2022, we asked 70 students to explain their favorite Ukrainian word with a short essay. Using qualitative content analysis, the article analyzes how these Ukrainian and German-speaking students justify their favorite Ukrainian words. It is found that family and private reasons play a special role in the choice of a favorite word.
Formulation and Evaluation of Budesonide-loaded Nanosponges for Colon-specific Drug Delivery Systems
Authors: Kapadne Chetana , Birari Sourabh , Gulecha Vishal , Shinde Anita , Sambare Aishwarya , Kshirsagar Sanjay 
Published: August 2024

Abstract

Background: The purpose of this work was to complex budesonide with cyclodextrin-based nanosponges to improve its solubility and stability. The current study focused on polysaccharide systems that have undergone minimal chemical alteration and have been used to target the colon. These targeted delivery and polysaccharide-based complexation methods are anticipated to aid in the creation of medication formulations for disorders affecting the colon, such as colorectal cancer. The goal of the current work was to use a Quality by Design (QbD) strategy to create budesonide-loaded nanosponges. The system consisted of nanosponges loaded with budesonide.

Methods: Nanosponges were formulated through microwave-assisted synthesis. Studies on drug release were conducted with a method changing power of hydrogen (pH) with enzyme. Quality by Design-based optimization with a 32 full factorial design was applied for the optimization of the process parameters including the β-cyclodextrin:diphenyl carbonate ratio and the reaction time. Responses were measured for three dependent variables: practical yield, percentage drug release, and percentage drug release at the fifth hour.

Results and Conclusions: The optimization model indicated a yield of 76.21%, a percentage drug release at the fifth hour of 24.61%, and a total drug release after 7 hours of 87.58%. The observed responses of the optimized process closely matched the predicted values. The above budesonide-loaded nanosponge formulations provide a targeted medicine for the colon and may be an effective method for treating colonic illness.
Reality TV? Leontyne Price, the NBC Tosca, and the Civil Rights Movement
Authors: Ward-Griffin Danielle 
Published: August 2024

This article examines television and its approach to opera casting practices during the civil rights movement. In particular, I trace the impact of NBC’s “Integration without Identification” hiring policy upon the NBC Opera Theatre in the 1950s. Focusing on the appearances of Leontyne Price, I argue that television—particularly its aesthetic of “realism”—influenced the perception of her performances, and by extension ideas of who could credibly perform roles in the standard repertory. Claims of realism have often limited Black singers’ opportunities in opera, but this article challenges the frequent equation of realism with traditional casting practices by showing the many ways in which opera was received as real in the early years of television.
The locus of the study is Price’s portrayal of the title role in Tosca (NBC 1955). I analyze how the camerawork, production choices, and the singer’s acting all contributed to Price’s depiction being acclaimed as “realistic” by the press. Using internal memos and reports from the network, I also show how the realism of Price’s performance, opposite a white romantic male lead, was judged, not according to whether it aligned with the opera’s plot, but whether it reflected the individual viewer’s own perspective on contemporary American reality. The article concludes by considering how Price’s TV performances may offer lessons for our present moment, as the opera industry seeks to reform its casting policies and eliminate systemic inequities.
Disparities in Access to Timely Waitlisting Among Pediatric Kidney Transplant Candidates
Authors: Maclay Lindsey M. , Yu Miko , Amaral Sandra , Adler Joel T. , Sandoval P. Rodrigo , Ratner Lloyd E. , Schold Jesse D. , Mohan Sumit , Husain Syed Ali 
Published: August 2024

BACKGROUND AND OBJECTIVES
Kidney transplantation with minimal or no dialysis exposure provides optimal outcomes for children with end-stage kidney disease. We sought to understand disparities in timely access to transplant waitlisting.

METHODS
We conducted a retrospective, registry-based cohort study of candidates ages 3 to 17 added to the US kidney transplant waitlist 2015 to 2019. We defined “preemptive waitlisting” as waitlist addition before receiving dialysis and compared demographics of candidates based on preemptive status. We used competing risk regression to determine the association between preemptive waitlisting and transplantation. We then identified waitlist additions age &gt;18 who initiated dialysis as children, thereby missing pediatric allocation prioritization, and evaluated the association between waitlisting with pediatric prioritization and transplantation.

RESULTS
Among 4506 pediatric candidates, 48% were waitlisted preemptively. Female sex, Hispanic ethnicity, Black race, and public insurance were associated with lower adjusted relative risk of preemptive waitlisting. Preemptive listing was not associated with time from waitlist activation to transplantation (adjusted hazard ratio 0.94, 95% confidence interval 0.87–1.02). Among transplant recipients waitlisted preemptively, 68% had no pretransplant dialysis, whereas recipients listed nonpreemptively had median 1.6 years of dialysis at transplant. Among 415 candidates initiating dialysis as children but waitlisted as adults, transplant rate was lower versus nonpreemptive pediatric candidates after waitlist activation (adjusted hazard ratio 0.54, 95% confidence interval 0.44–0.66).

CONCLUSIONS
Disparities in timely waitlisting are associated with differences in pretransplant dialysis exposure despite no difference in time to transplant after waitlist activation. Young adults who experience delays may miss pediatric prioritization, highlighting an area for policy intervention.
Diagnostic Accuracy of Clinical Sign Algorithms to Identify Sepsis in Young Infants Aged 0 to 59 Days: A Systematic Review and Meta-analysis
Authors: Fung Alastair , Shafiq Yasir , Driker Sophie , Rees Chris A. , Mediratta Rishi P. , Rosenberg Rebecca , Hussaini Anum S. , Adnan Jana , Wade Carrie G. , Chou Roger , Edmond Karen M. , North Krysten , Lee Anne CC 
Published: August 2024

CONTEXT
Accurate identification of possible sepsis in young infants is needed to effectively manage and reduce sepsis-related morbidity and mortality.

OBJECTIVE
Synthesize evidence on the diagnostic accuracy of clinical sign algorithms to identify young infants (aged 0–59 days) with suspected sepsis.

DATA SOURCES
MEDLINE, Embase, CINAHL, Global Index Medicus, and Cochrane CENTRAL Registry of Trials.

STUDY SELECTION
Studies reporting diagnostic accuracy measures of algorithms including infant clinical signs to identify young infants with suspected sepsis.

DATA EXTRACTION
We used Cochrane methods for study screening, data extraction, risk of bias assessment, and determining certainty of evidence using Grading of Recommendations Assessment Development and Evaluation.

RESULTS
We included 19 studies (12 Integrated Management of Childhood Illness [IMCI] and 7 non-IMCI studies). The current World Health Organization (WHO) 7-sign IMCI algorithm had a sensitivity of 79% (95% CI 77%–82%) and specificity of 77% (95% CI 76%–78%) for identifying sick infants aged 0–59 days requiring hospitalization/antibiotics (1 study, N = 8889). Any IMCI algorithm had a pooled sensitivity of 84% (95% CI 75%–90%) and specificity of 80% (95% CI 64%–90%) for identifying suspected sepsis (11 studies, N = 15523). When restricting the reference standard to laboratory-supported sepsis, any IMCI algorithm had a pooled sensitivity of 86% (95% CI 82%–90%) and lower specificity of 61% (95% CI 49%–72%) (6 studies, N = 14278).

LIMITATIONS
Heterogeneity of algorithms and reference standards limited the evidence.

CONCLUSIONS
IMCI algorithms had acceptable sensitivity for identifying young infants with suspected sepsis. Specificity was lower using a reference standard of laboratory-supported sepsis diagnosis.
Monitorización del contenido de fósforo del olivo mediante robot terrestre
Authors: Noguera Miguel , Millan Borja , Moro Rocio , Andújar José Manuel 
Published: August 2024

El olivar es un cultivo de gran importancia en los países de la cuenca mediterránea. En las últimas décadas, el sector olivarero ha experimentado una modernización en busca de incrementar la rentabilidad y productividad de sus explotaciones. En este contexto, la gestión basada en agricultura de precisión está mostrando un potencial prometedor. En este sentido, el presente trabajo muestra una metodología para la caracterización del contenido foliar de P en olivares superintensivos. El método propuesto se basa en redes neuronales artificiales alimentadas con información espectral extraída de imágenes adquiridas por un robot terrestre con capacidad para la navegación autónoma. Para evaluar la metodología propuesta se definió un planteamiento experimental basado en exponer una parcela de olivos superintensivos a tratamientos de fertirriego diferenciales para generar variabilidad en cuanto al contenido foliar de P. El índice de correlación entre los valores de obtenidos por análisis químico y la respuesta del modelo (R2=0.72) sugieren la idoneidad de la metodología propuesta.
Filmoteca PUCP: historia y patrimonio audiovisual nacional
Authors: Díaz-Cervantes Katherine , Flores Saldaña Annia Tamara 
Published: August 2024

La Filmoteca PUCP es el archivo nacional representante en la Federación Internacional de Archivos Fílmicos (FIAF) y preservador del patrimonio nacional peruano. Esta investigación contribuye a un mayor conocimiento y conciencia del papel que cumple en la preservación audiovisual. En este sentido, el objetivo general de este artículo es, a través del caso de la Filmoteca PUCP, proponer un modelo de referencia para estudiar los archivos fílmicos. Los objetivos específicos son delimitar los ámbitos de análisis interno y externo de un archivo fílmico, proponer la metodología FODA enfocada en los archivos, e identificar las carencias o limitaciones que tiene esta metodología para el estudio de los archivos fílmicos.