bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterometallic FeIII/K Coordination Polymer with a Wide Thermal Hysteretic Spin Transition at Room Temperature
Authors: Kang Soonchul , Shiota Yoshihito , Kariyazaki Akira , Kanegawa Shinji , Yoshizawa Kazunari , Sato Osamu 
Published: November 2015

AbstractThe anionic FeIII complex exhibiting cooperative spin transition with a wide thermal hysteresis near room temperature, K[Fe(5‐Brthsa)2] (5‐Brthsa‐H2=5‐bromosalicylaldehyde thiosemicarbazone), is reported. The hysteresis (Δ=69 K in the first cycle) shows a one‐step transition in heating mode and a two‐step transition in cooling mode. X‐ray structure analysis showed that the coexistence of hydrogen bond and cation–π interactions, as well as alkali metal coordination bonds, to give 2D coordination polymer structure. This result is contrary to previous reports of broad thermal hysteresis induced by coordination bonds of FeII spin crossover coordination polymers (with 1D/3D structures), and by strong intermolecular interactions in the molecular packing through π–π stacking or hydrogen‐bond networks. As a consequence, the importance, or the very good suitability of alkali metal‐based coordination bonds and cation–π interactions for communicating cooperative interactions in spin‐crossover (SCO) compounds must be reconsidered.
Maximum microalgae biomass harvesting via flocculation in large scale photobioreactor cultivation
Authors: Selesu Nelson F. H. , V. de Oliveira Thamayne , Corrêa Diego O. , Miyawaki Bruno , Mariano André B. , Vargas José V. C. , Vieira Rafael B. 
Published: November 2015

AbstractThis study evaluated the ability of Tanfloc SG flocculation to recover microalgae biomass cultivated in a tubular photobioreactor using swine wastewater effluent as the culture media in a pilot‐scale microalgae production plant. The objective function was the flocculation efficiency (ηf), which was evaluated by central composite design (CCD) experiments which varied the Tanfloc concentration (TC) and pH. Subsequently, the biomass recoveries of highly efficient flocculants recommended by the literature and the CCD conditions of Tanfloc were compared. The maximum flocculation efficiency (96.7 ± 1.0 %) was obtained for the following optimal conditions: 210 mg/L Tanfloc concentration, pH 7.8. After jar test experiments, the scale‐up of the process was performed by using the best obtained results and applying Tanfloc in a 1 m3 flocculator where the complementary analyses demonstrated efficient nitrogen, carbon, and biomass removal. The flocculation efficiency obtained with Tanfloc was equivalent to that of most conventional flocculants currently used. However, Tanfloc presented the following economic advantages with respect to other flocculants: i) its nontoxic nature allows for low‐cost disposal; and ii) its low market price makes it a promising alternative for harvesting microalgae biomass.
A Highly Selective Chemosensor for Cu2+ Based on a Diarylethene Linking an Aminoquinoline Unit
Authors: Zhang Congcong , Fan Congbin , Pu Shouzhi , Liu Gang 
Published: November 2015

AbstractA new diarylethene derivative containing an aminoquinoline unit was synthesized and its structure was determined by single crystal X‐ray diffraction analysis. Its properties such as photochromism, fluorescent switches and detection for metal ions were measured. The results indicated that the closed‐ring of the diarylethene was highly selective toward Cu2+ with an obvious absorption decrease and color changes from blue to colorless, even in the presence of other metal ions. The binding constant for the closed isomer of this new diarylethene and Cu2+ was 2.0×104 L·mol−1 and the limit of detection for Cu2+ was calculated to be lower than that in drink water. Finally, a logic circuit was constructed by using the absorption intensity as the output signal with the inputs of the combinational stimuli of light and Cu2+.
Synthesis and Acid‐Catalyzed Cyclization of 2‐Alkenylstilbenes: a New Approach to the Substituted Indenes
Authors: Ding Wei , Shi Xiaoxin , Lu Xia 
Published: November 2015

AbstractA base‐catalyzed ring‐opening of 1‐benzylisochromans 1 firstly produced 2‐alkenylstilbenes 2, which then underwent a mild acid‐catalyzed intramolecular cyclization to furnish 1,2‐disubstituted indenes 3 in high yields. Subsequently, a base‐catalyzed isomerization of the 1,2‐disubstituted indenes 3 afforded the more stable 2,3‐disubstituted indenes 4 in almost quantitative yields.
A Hierarchically Porous Metal‐Organic Framework from Semirigid Ligand for Gas Adsorption
Authors: Liu Lizhen , Ye Yingxiang , Yao Zizhu , Zhang Liuqin , Li Ziyin , Wang Lihua , Ma Xiuling , Chen Qian‐Huo , Zhang Zhangjing , Xiang Shengchang 
Published: November 2015

AbstractHierarchically porous materials play an important role in facilitating mass transport and improving efficiency of adsorption and separation processes. In this paper, a new strategy is proposed to realize a hierarchically porous metal‐organic framework ([Cu2(OH)(L)]·(DMF)0.8 (FJU‐11, H3L=3,5‐(4‐carboxybenzyloxy)benzoic acid, DMF=N,N‐dimethylformamide) via using semi‐rigid multi‐carboxylic acids. Interestingly, FJU‐11 possesses the large adsorption capacities and small isosteric heats toward CO2. The column breakthrough experiment for FJU‐11 highlights its potential application in the separation of the flue gas.
Postsynthetic Modification of Metal‐Organic Frameworks through Click Chemistry
Authors: Gui Bo , Meng Xiangshi , Xu Hai , Wang Cheng 
Published: November 2015

AbstractThe postsynthetic modification (PSM) of metal‐organic frameworks (MOFs) has emerged as a powerful tool to chemically tailor the interior of MOFs. In this review, we summarize the research progress of PSM of MOFs through click chemistry, including azide‐alkyne click reaction and thiol‐ene reaction.
Three‐Component Reaction for Construction of Spiro[indoline‐3,7′‐thiazolo[3,2‐a]pyridines] and Spiro[benzo[4,5]thiazolo[3,2‐a]pyridine‐3,3′‐indolines]
Authors: Yang Fan , Sun Jing , Yan Chaoguo 
Published: November 2015

AbstractThe three‐component reaction of thiazole (benzothiazole), dialkyl but‐2‐ynedioate, and isatinylidene malononitriles in toluene at 110–120°C in a sealed tube afforded a mixture of cis/trans‐isomers of functionalized diastereoisomeric spiro[indoline‐3,7′‐thiazolo[3,2‐a]pyridines] and spiro[benzo[4,5]thiazolo[3,2‐a]pyridine‐3,3′‐indolines] in good yields. Both cis‐isomers and trans‐isomers were successfully separated out and fully characterized with spectroscopy and single crystal determination. Under similar conditions, the three‐component reaction containing 2‐(1,3‐dioxo‐1H‐inden‐2(3H)‐ylidene)malononitrile resulted in spiro[indene‐2,7′‐thiazolo[3,2‐a]pyridine] derivatives.
Urine cytology in monitoring recurrence in urothelial carcinoma after radical cystectomy and urinary diversion
Authors: Chen Haiyan , Liu Lin , Pambuccian Stefan E. , Barkan Güliz A. , Quek Marcus L. , Wojcik Eva M. 
Published: November 2015

BACKGROUNDAfter radical cystectomy and urinary diversion (RC‐UD), upper urinary tract and urethral recurrences of urothelial carcinoma (UCa) are reported to occur in 2% to 17% of patients. The objective of the current study was to determine the performance of urinary cytology (UCy) in the diagnosis of recurrences in the remnant urothelium (RRU) after RC‐UD.METHODSThe authors retrospectively identified all patients who underwent RC‐UD for UCa at the study institution from January 2002 to April 2014, and collected data from all available follow‐up UCy and biopsies. Cytologies were classified as unsatisfactory, negative, suspicious, positive for malignancy, or atypical urothelial cells (AUC). The authors calculated the sensitivity, specificity, positive predictive value, and negative predictive value of suspicious or positive UCy for the diagnosis of histologically confirmed RRU.RESULTSOf the 222 patients who underwent RC‐UD for UCa of the urinary bladder during the study period, 111 had at least 1 follow‐up UCy performed at the study institution, for a total of 477 UCy samples. During a mean follow‐up interval of 40.8 months (range, 3‐155 months), the RRU rate was 9.9% (11 of 111 patients). Positive/suspicious UCy results were noted in 12 of 111 patients, 9 of whom had RRU. A diagnosis of AUC was made in 8.6% of samples from 29 patients (41 of 477 samples). The sensitivity, specificity, positive predictive value, and negative predictive value of UCy for RRU were 82%, 97%, 75%, and 98%, respectively. Six of the 28 patients with diagnoses of AUC (21.4%) were eventually diagnosed with RRU.CONCLUSIONSIn the current series, UCy demonstrated good sensitivity and high specificity for the detection of disease recurrence of UCa after RC‐UD. Cancer Cytopathol 2016;124:273–8. © 2015 American Cancer Society.
Photoinduced Dynamics and Toxicity of a Cancer Drug in Proximity of Inorganic Nanoparticles under Visible Light
Authors: Chaudhuri Siddhi , Sardar Samim , Bagchi Damayanti , Dutta Shreyasi , Debnath Sushanta , Saha Partha , Lemmens Peter , Pal Samir Kumar 
Published: November 2015

AbstractDrug sensitization with various inorganic nanoparticles (NPs) has proved to be a promising and an emergent concept in the field of nanomedicine. Rose bengal (RB), a notable photosensitizer, triggers the formation of reactive oxygen species under green‐light irradiation, and consequently, it induces cytotoxicity and cell death. In the present study, the effect of photoinduced dynamics of RB upon complexation with semiconductor zinc oxide NPs is explored. To accomplish this, we successfully synthesized nanohybrids of RB with ZnO NPs with a particle size of 24 nm and optically characterized them. The uniform size and integrity of the particles were confirmed by high‐resolution transmission electron microscopy. UV/Vis absorption and steady‐state fluorescence studies reveal the formation of the nanohybrids. ultrafast picosecond‐resolved fluorescence studies of RB–ZnO nanohybrids demonstrate an efficient electron transfer from the photoexcited drug to the semiconductor NPs. Picosecond‐resolved Förster resonance energy transfer from ZnO NPs to RB unravel the proximity of the drug to the semiconductor at the molecular level. The photoinduced ROS formation was monitored using a dichlorofluorescin oxidation assay, which is a conventional oxidative stress indicator. It is observed that the ROS generation under green light illumination is greater at low concentrations of RB–ZnO nanohybrids compared with free RB. Substantial photodynamic activity of the nanohybrids in bacterial and fungal cell lines validated the in vitro toxicity results. Furthermore, the cytotoxic effect of the nanohybrids in HeLa cells, which was monitored by MTT assay, is also noteworthy.
Interleukin‐6 receptor inhibitor tocilizumab ameliorates periodontal inflammation in patients with rheumatoid arthritis and periodontitis as well as tumor necrosis factor inhibitors
Authors: Kobayashi Tetsuo , Ito Satoshi , Kobayashi Daisuke , Kojima Anri , Shimada Atsushi , Narita Ichiei , Murasawa Akira , Nakazono Kiyoshi , Yoshie Hiromasa 
Published: November 2015

AbstractInterleukin‐6 (IL‐6) may play a pathological role in rheumatoid arthritis (RA) and periodontitis. Although the efficacy of medication with IL‐6 receptor inhibitor, tocilizumab (TCZ), has been demonstrated in the treatment of RA, very little is known about whether TCZ therapy affects periodontitis. The aim of the present study is to compare periodontal condition in patients with RA and periodontitis before and after TCZ therapy. The study participants consisted of 20 patients with RA and periodontitis who were treated with TCZ and 40 patients with RA and periodontitis who received medication with tumor necrosis factor inhibitor (TNFI). Clinical periodontal and rheumatologic assessments and serum biochemical measurements using enzyme‐linked immunosorbent assays were performed at baseline and 3 and 6 months later. TCZ and TNFI therapies significantly reduced periodontal inflammation that was determined by gingival index, bleeding on probing, and probing depth (p < 0.017), although plaque levels were comparable before and after the therapies. Both therapies also significantly decreased disease activity score including 28 joints using C‐reactive protein (CRP), number of tender and swollen joints, and serum levels of anti‐cyclic citrullinated peptide antibodies, rheumatoid factor, CRP, and matrix metalloproteinase‐3 (p < 0.017). Additionally, a significant decrease was observed in periodontal clinical attachment level after TCZ therapy (p < 0.017), but not after TNFI therapy. TCZ therapy significantly decreased serum levels of TNF‐α, total immunoglobulin G, and serum amyloid A (p < 0.017), although serum levels of IL‐6 and soluble IL‐6R were significantly increased (p < 0.017). These results suggest a beneficial effect of TCZ therapy on levels of periodontal inflammation in patients with RA and periodontitis, which might be related to decrease in serum inflammatory mediators.
Designing Photoelectrodes for Photocatalytic Fuel Cells and Elucidating the Effects of Organic Substrates
Authors: Hu Chenyan , Kelm Denis , Schreiner Manuel , Wollborn Tobias , Mädler Lutz , Teoh Wey Yang 
Published: November 2015

AbstractPhotocatalytic fuel cells (PFCs) are constructed from anodized photoanodes with the aim of effectively converting organic materials into solar electricity. The syntheses of the photoanodes (TiO2, WO3, and Nb2O5) were optimized using the statistical 2k factorial design. A systematic study was carried out to catalog the influence of eleven types of organic substrate on the photocurrent responses of the photoanodes, showing dependence on the adsorption of the organic substrates and on the associated photocatalytic degradation mechanisms. Strong adsorbates, such as carboxylic acids, generated high photocurrent enhancements. Simple and short‐chained molecules, such as formic acid and methanol, are the most efficient in the corresponding carboxylic acid and alcohol groups as a result of their fast degradation kinetics. The TiO2‐based PFC yielded the highest photocurrent and obtainable power, whereas the Nb2O5‐based PFC achieved the highest open‐circuit voltage, which is consistent with its most negative Fermi level.
Efficient power pad assignment for multi‐voltage SoC and its application in floorplanning
Authors: Chu Zhufei , Xia Yinshui , Wang Lunyao , Wang Jian 
Published: November 2015

SummaryMulti‐voltage techniques are being developed to improve power savings by providing lower supply voltages for noncritical blocks under the performance constraint. However, the resulted lower voltage drop noise margin brings serious obstacles in power/ground (P/G) network design of the wire‐bonding package. For voltage drop optimization, both block and power pad positions are important factors that need to be considered. Traditional multi‐voltage floorplanning methods use rough estimation to evaluate the P/G network resource without considering the locations of power pads. To remedy this deficiency, in this paper, an efficient voltage drops aware power pad assignment (PPA) method is proposed, and it is further integrated into a floorplanning algorithm. We first present a fast PPA method for each power domain by the spring model. Then, to evaluate voltage drops during floorplanning iterations, the weighted distance from the blocks to the power pads is adopted as an optimization objective instead of time‐consuming matrix computation. Experimental results on Gigascale System Research Center (GSRC) benchmark circuits indicate that the proposed method generates an optimized placement of power pads and floorplanning of blocks with high efficiency. Copyright © 2015 John Wiley & Sons, Ltd.
High‐throughput linear optical stretcher for mechanical characterization of blood cells
Authors: Roth Kevin B. , Neeves Keith B. , Squier Jeff , Marr David W. M. 
Published: November 2015

AbstractThis study describes a linear optical stretcher as a high‐throughput mechanical property cytometer. Custom, inexpensive, and scalable optics image a linear diode bar source into a microfluidic channel, where cells are hydrodynamically focused into the optical stretcher. Upon entering the stretching region, antipodal optical forces generated by the refraction of tightly focused laser light at the cell membrane deform each cell in flow. Each cell relaxes as it flows out of the trap and is compared to the stretched state to determine deformation. The deformation response of untreated red blood cells and neutrophils were compared to chemically treated cells. Statistically significant differences were observed between normal, diamide‐treated, and glutaraldehyde‐treated red blood cells, as well as between normal and cytochalasin D‐treated neutrophils. Based on the behavior of the pure, untreated populations of red cells and neutrophils, a mixed population of these cells was tested and the discrete populations were identified by deformability. © 2015 International Society for Advancement of Cytometry
Vascular Health Profile predicts cardiovascular outcomes in patients with diabetes
Authors: Rogers Wade T. , Zhang Lifeng , Welden Scott , Krieger Benjamin , Rickels Michael , Moore Jonni S. , Mohler Emile R. 
Published: November 2015

BackgroundWe previously reported the development of a novel high dimensional cytomic assay, the Vascular Health Profile (VHP) based on measurements of angiogenic circulating hematopoietic stem and progenitor cells (CHSPCAng) and extracellular vesicles (EVs), that discovered a unique signature, differentiating the vascular status of diabetics and normal healthy controls. Here, we present data from a 3‐year follow‐up to evaluate the power of the VHP to identify individuals at risk for cardiovascular (CV) events.MethodsThe original data were generated as previously described by measuring a broad panel of progenitor cells and EVs and profiled using cytometric fingerprinting. Subjects were classified into groups according to the occurrence of adjudicated CV events including myocardial infarction, stroke, major adverse cardiovascular events, revascularization, and irregular rhythm. Cross‐validated Linear Discriminate Analysis (LDA) models were constructed and used to predict the occurrence of events, and were evaluated for predictive accuracy (AUC, area under the curve) using receiver operating characteristic (ROC) analysis.ResultsOver the period of this analysis, follow‐up data was obtained on 87 subjects, with 32 events occurring overall, and only in the diabetic group. In all cases, the VHP added significant predictive power, in the form of ROC analysis, for all evaluated outcomes with the exception of irregular rhythm.ConclusionsThe VHP, a relatively simple blood test, can provide sensitive and clinically relevant information on the vascular status of a patient that may be useful for a variety of applications including drug development, clinical risk assessment, and companion diagnostics. © 2015 International Clinical Cytometry Society
Thymic output: Assessment ofCD4+recent thymic emigrants andT‐Cell receptor excision circles in infants
Authors: Ravkov Eugene , Slev Patricia , Heikal Nahla 
Published: November 2015

BackgroundCD4+recent thymic emigrants (CD4+RTEs) constitute a subset of T cells recently generated in the thymus and exported into peripheral blood. CD4+RTEs have increased copy numbers of T‐cell receptor excision circles (TREC). They are characterized by the expression of CD31 on naïve CD4 T‐cells. We aimed to validate a flow‐cytometry assay to enumerate CD4+RTEs and assess its performance in relation to TREC measurement.MethodsCD4+RTEs cell count in peripheral blood was measured to determine sample stability, precision, linearity, and to establish reference ranges. TRECs were measured using qPCR assay performed with DNA isolated from peripheral blood. CD4+RTEs, TRECs, and flow cytometry results for major T‐cell markers were assessed in 50 infants less than 2 years of age.ResultsInter‐and intra‐assay precisions (% CV) were 1.5–12.2 and 1.5–7.0, respectively. Linearity studies showed that the results are linear over a range of 0.7 to 403.0 CD4+RTEs/μL of blood. There was 84% agreement (42 of 50) between CD4+RTEs and TRECs qualitative results for the infant samples. CD4+RTEs reference ranges in 17 healthy children was in agreement with published data, while that of the healthy adults were 51–609 cells/μL of blood.ConclusionThe validation results provide acceptable measures of the CD4+RTEs test performance within CAP/CLIA frameworks. CD4+RTEs and TRECs assays show high agreement in the infant population. The CD4+RTEs test can be used as a confirmation for the TREC results along with or as an alternative to T‐cell phenotyping in infants with repeatedly low TRECs concentrations. © 2015 International Clinical Cytometry Society
Ba2InTaO6 – A Partially B‐Site‐Ordered Double Perovskite for Overall Water Splitting
Authors: Song Kai , Yang Jia , Jiang Pengfei , Gao Wenliang , Cong Rihong , Yang Tao 
Published: November 2015

AbstractCompletely B‐site‐ordered Ba2InTaO6 has been prepared previously by prolonged heating at 1500 °C; here, we significantly lowered the annealing temperature to 1130 °C under H2/Ar dynamic flow and obtained a partially ordered (ca. 74 %) double perovskite, as determined by Rietveld refinement of the powder X‐ray diffraction data. As a wide‐band‐gap semiconductor, Ba2InTaO6 possesses photocatalytic activity for overall water splitting under UV irradiation, though the gas evolution rates of 12.9 and 6.6 μmol/h/g for H2 and O2 generation, respectively, are low. With the assistance of methanol as a sacrificial reagent, the H2 evolution rate increases to 50.5 μmol/h/g, which indicates that the surficial charge recombination rate is really high. We applied the typical cocatalyst‐loading method to this material, and with 1 wt.‐% PtOx and NiOx, the H2 production rates in pure water were further improved to 16.0 and 18.4 μmol/h/g, respectively. Attempts to dope Ba2InTaO6 with first‐row transition metals (Ti, V, Cr, Mn, Fe, Co, and Ni) led to a general enhancement of the light‐harvesting ability; however, the experimental water‐splitting activity did not improve. We believe that the doped cations most likely behaved as recombination centers for photogenerated charges. Considering its structural similarity to the well‐known catalyst InTaO4:Ni, Ba2InTaO6 possesses the potential to extend its photocatalytic activity to the visible‐light region but needs further enhancement.
Heterometallic AgI–IrIII Hydride Coordination Polymers Bridged by IrIII Metalloligands
Authors: Maekawa Masahiko , Kubo Yukimi , Sugimoto Kunihisa , Okubo Takashi , Kuroda‐Sowa Takayoshi , Munakata Megumu 
Published: November 2015

AbstractA new type of IrIII metalloligands containing an unsaturated nitrogen coordination site, [Ir(H)2(PPh3)2(pprd)]BF4·2CHCl3 (1), [Ir(H)2(PPh3)2(Me2bpm)]BF4·CHCl3 (2), {[Ir(H)2(PPh3)2(Me2bpm)]PF6·CHCl3}4 (3), [Ir(H)2(PPh3)2(biqz)]BF4·2CHCl3 (4), and [Ir(H)2(PPh3)2(biqz)]PF6 (5), have been prepared by reaction of [Ir(H)2(PPh3)2(Me2CO)2]X (X = BF4 or PF6) with 4‐(2‐pyridyl)pyrimidine (pprd), 6,6′‐dimethyl‐4,4′‐bipyrimidine (Me2bpm), or 4,4′‐biquinazoline (biqz). Subsequently, three novel heterometallic AgI–IrIII hydride coordination polymers, {[Ir(H)2(μ‐pprd)(PPh3)2Ag(η‐CF3COO)]BF4·Me2CO}n (6), {[Ir(H)2(μ‐biqz)(PPh3)2Ag2(μ‐CF3COO)3]·Me2CO}n (7), and {[Ir(H)2(μ‐Me2bpm)(PPh3)2Ag2(μ‐CF3COO)2]PF6·2Me2CO}n (8) have been constructed by reaction of the IrIII metalloligands 1, 3, and 5 with AgCF3COO. In coordination polymer 6, the [Ir(H)2(PPh3)2(pprd)]3+ units are linked through the AgI atoms to form a 1D zigzag chain structure. In coordination polymer 7, the dinuclear [Ag2(μ‐CF3COO)3]– units are linked through the terminal N atoms of biqz in two different [Ir(H)2(PPh3)2(biqz)]3+ units to form a 1D zigzag chain structure. In coordination polymer 8, the [Ag2(μ‐CF3COO)2] frameworks are linked through the terminal N atoms of Me2bpm and the IrIII atom in two different [Ir(H)2(PPh3)2(Me2bpm)]3+ units to form a waved rectangular cavity. These waved rectangular cavities are connected to each other to afford a unique 2D sheet structure.