bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seroepidemiologic investigation of an outbreak of pandemic influenza A H1N1 2009 aboard a US Navy Vessel—San Diego, 2009
Authors: Khaokham Christina B. , Selent Monica , Loustalot Fleetwood V. , Zarecki Shauna Mettee , Harrington Douglas , Hoke Eileen , Faix Dennis J. , Ortiguerra Ryan , Alvarez Bryan , Almond Nathaniel , McMullen Kellie , Cadwell Betsy , Uyeki Timothy M. , Blair Patrick J. , Waterman Stephen H. 
Published: March 2013

BackgroundDuring summer 2009, a US Navy ship experienced an influenza‐like illness outbreak with 126 laboratory‐confirmed cases of pandemic influenza A (H1N1) 2009 virus among the approximately 2000‐person crew.MethodsDuring September 24–October 9, 2009, a retrospective seroepidemiologic investigation was conducted to characterize the outbreak. We administered questionnaires, reviewed medical records, and collected post‐outbreak sera from systematically sampled crewmembers. We used real‐time reverse transcription‐PCR or microneutralization assays to detect evidence of H1N1 virus infection.ResultsRetrospective serologic data demonstrated that the overall H1N1 virus infection attack rate was 32%. Weighted H1N1 virus attack rates were higher among marines (37%), junior‐ranking personnel (34%), and persons aged 19–24 years (36%). In multivariable analysis, a higher risk of illness was found for women versus men (odds ratio [OR] = 2·2; 95% confidence interval [CI]: 1·1–4·4), marines versus navy personnel (OR = 1·7; 95% CI, 1·0–2·9), and those aged 19–24 versus ≥35 years (OR = 3·9; 95% CI, 1·2–12·8). Fifty‐three percent of infected persons did not recall respiratory illness symptoms. Among infected persons, only 35% met criteria for acute respiratory illness and 11% for influenza‐like illness.ConclusionsApproximately half of H1N1 infections were asymptomatic, and thus, the attack rate was higher than estimated by clinical illness alone. Enhanced infection control measures including pre‐embarkation illness screening, improved self‐reporting of illness, isolation of ill and quarantine of exposed contacts, and prompt antiviral chemoprophylaxis and treatment might be useful in controlling shipboard influenza outbreaks.
Insuffisances de la protection sociale en matière de soins de santé et de soins de longue durée en Europe: les personnes âgées risquent‐elles la faillite?
Authors: Scheil‐Adlung Xenia , Bonan Jacopo 
Published: March 2013

RésuméAlors que les dépenses publiques consacrées aux soins de santé et aux soins de longue durée sont contrôlées depuis de nombreuses années dans les pays européens, l'on s’intéresse beaucoup moins aux conséquences financières que subissent les personnes âgées qui doivent engager des dépenses privées pour accéder à ces soins. En nous appuyant sur des données transversales représentatives de la population âgée de 11 pays européens collectées en 2004 dans le cadre de l'enquête sur la santé, le vieillissement et la retraite en Europe (Survey of Health, Ageing and Retirement in Europe, SHARE), nous avons constaté que les dépenses privées pour des soins de santé et des soins de longue durée sont très fréquentes parmi les personnes âgées des pays européens et qu'elles ont une incidence marquée sur le revenu disponible. Près de 95 pour cent des personnes âgées paient leurs soins de santé et 5 pour cent leurs soins de longue durée, ce qui entraîne une réduction de leur revenu comprise respectivement entre 5 et 10 pour cent. La faillite, suite à des dépenses privées trop élevées, touche 0,7 pour cent des foyers âgés utilisant les soins de santé et 0,5 pour cent de ceux recourant aux soins de longue durée. Les plus durement frappés sont les plus pauvres, les femmes et les plus âgés.
Le système de santé de la République populaire de Chine: entre privatisation et système public de santé
Authors: Darimont Barbara , Liu Dongmei 
Published: March 2013

RésuméCes dernières années, la Chine a réformé sa politique de santé à de multiples reprises. Ces réformes ont souvent fait émerger de nouvelles difficultés, qui ont nécessité d'autres changements. La dernière réforme en date tente de trouver un moyen terme entre un modèle reposant sur la fourniture de soins par le secteur public et un modèle fondé sur l'assurance individuelle privée. La Chine emboîte ainsi le pas de pays qui, après avoir, dans les années 90 et au début du XXIe siècle, renforcé la place du secteur privé dans leur système de santé, s’orientent aujourd'hui vers un système de santé public. Toutefois, ces réformes incessantes ont conduit à un manque de transparence du fonctionnement du système de santé et, par conséquent, à une perte de confiance du public. Bien que de nombreuses incertitudes demeurent quant à la direction dans laquelle le système de santé chinois va évoluer, il est possible qu'un financement hybride, associant financement par l'impôt et assurance sociale, s’impose et constitue un modèle dont d'autres pays pourraient s’inspirer.
Die Achillesferse bei der Verwendung von Skaleneffekten in der Verwaltung der sozialen Sicherheit: Das Beispiel des Universal Credit im Vereinigten Königreich
Authors: Seddon John , O'Donovan Brendan 
Published: March 2013

AuszugDieser Artikel umfasst eine kritische Betrachtung des geplanten Verfahrens zur Bereitstellung von reformierten Sozialleistungen in der Form eines Universal Credit (UC) im Vereinigten Königreich. Es wird die Auffassung vertreten, dass der UC schon deshalb zum Scheitern verurteilt ist, weil das entsprechende Gesetz dahin gehend erweitert wurde, auch den Modus („standardmä
ßig digital“) der Bereitstellung von Leistungen vorzuschreiben. Die Autoren legen dar, dass dem Verfahren ein ganzer Satz von auf den ersten Blick nicht sichtbaren, aber omnipräsenten Annahmen zu positiven Skaleneffekten in der Verwaltung zugrunde liegt, mit dem die Regierung ihr erklärtes Ziel erreichen will: nämlich, dass sich „Arbeit lohnt“. Im Anschluss wird die „Vanguard‐Methode“ von Seddon als praktisches Beispiel dafür vorgestellt, wie eine lokale Behörde für Wohnbeihilfe einen besseren Dienst anzubieten vermag. Mit dieser Methode können innert der Hälfte der offiziellen Zeit‐Zielvorgaben 50 Prozent mehr Anfragen mit weniger Ressourcen bearbeitet werden. Der Artikel schließt mit dem Aufruf, beim Entwurf von Gesetzen die realen Gegebenheiten stärker zu gewichten.
Radiofrequency ablation of renal tumours with clinical, radiographical and pathological results
Authors: Karam Jose A. , Ahrar Kamran , Vikram Raghunandan , Romero Claudio A. , Jonasch Eric , Tannir Nizar M. , Rao Priya , Wood Christopher G. , Matin Surena F. 
Published: March 2013

What's known on the subject? and What does the study add?
Radiological imaging is heavily relied on for follow up after renal ablative therapy. We show that while this is largely reliable, there are quantifiable false negative and false positive findings. A non‐involuting zone of ablation should be considered for multisite‐directed core biopsies even in the absence of detectable enhancement.
Objective
To evaluate our experience with radiofrequency ablation (RFA) for renal masses and to report on clinical, radiological and post‐RFA biopsy results.
Patients and Methods
The study collected clinical, radiological and pathological data from 150 consecutive patients who were treated with RFA of a renal mass between 2002 and 2008 at a tertiary referral centre.
Post‐ablation biopsies were performed in patients with non‐involuting lesions or suspicion of recurrence on imaging.
Comparisons were performed using the Mann–Whitney U‐test.
Survival was estimated using the Kaplan–Meier method.
Results
Renal malignancy was found in 72.1% of patients based on the initial diagnostic biopsy. Median tumour size was 2.6 cm, 22.7% of patients had a solitary kidney, and most were central tumours.
The mean follow‐up period was 40.1 month. There was no recurrence in 96.7% of the entire cohort. Cancer‐specific survival for 106 patients with sporadic, localized, biopsy proven renal malignancy was 100% at 38.5 months.
Biopsies were obtained in 43 patients for a median of 21 months after RFA.
Among 38 patients who had biopsy for non‐involuting, non‐enhancing zones of ablation, three (7.9%) were positive.
Conclusions
Short‐term cancer‐specific survival after RFA remains excellent and most cases are successful based on a combination of imaging and post‐ablation biopsies performed almost 2 years after treatment.
There were four out of 150 (2.7%) patients who had recurrences with tissue confirmation; one of these patients was detected on imaging and three (2%) were radiologically occult.
The absence of enhancement in the setting of non‐involuting lesions is not always a guarantee of a successful ablation.
Patrie européenne ou Europe des patries? La construction d'un nouvel espace littéraire européen dans l'immédiat après‐guerre (1918–1925)
Authors: Mus Francis 
Published: March 2013

Immédiatement après la Première Guerre mondiale, plusieurs littératures nationales européennes se voient confrontées à un défi de taille : comment, dans cette nouvelle constellation sociétale, concevoir une nouvelle littérature européenne ? A partir d'une double distinction entre identité collective/partielle et identité égalitaire/hiérarchique, nous étudierons d'abord les différentes modalités théoriques de ces discours de (re)construction. Celles‐ci seront ensuite exemplifiées à partir d'une analyse portant sur le type et le statut de la langue à adopter dans chaque modalité individuelle. Cette étude se base sur un corpus de textes d'avant‐garde belges, mais – vu le caractère international de la problématique – les conclusions valent également pour d'autres littératures européennes.
Protective role of human insulin against the cytotoxicity associated with human mutant S20G islet amyloid polypeptide
Authors: Morita Shuhei , Ueyama Minoru , Sakagashira Setsuya , Shimajiri Yoshinori , Yamana Akiko , Furuta Machi , Sanke Tokio 
Published: March 2013

AbstractAims/IntroductionIslet amyloid polypeptide (IAPP) is a main component of islet amyloid in type 2 diabetes and cosecreted from β‐cell with insulin. Clinical evidence from the patients with S20G mutation of the IAPP gene, as well as experimental evidence that insulin could inhibit amyloid formation of IAPP, suggests that a gradual reduction of insulin could be related to the cytotoxicity associated with S20G‐IAPP through long‐term deterioration of β‐cells in type 2 diabetes. Our objective was to show an effect of human insulin on S20G‐IAPP associated cytotoxicity.Materials and MethodsWe analyzed the cytotoxicity associated with S20G‐IAPP by controlling human insulin expression using adenovirus vectors with micro ribonucleic acid specifically against human insulin in endocrine AtT‐20ins cells, which express human insulin permanently. Additionally, we carried out a follow‐up study of circulating IAPP and insulin in type 2 diabetic patients.ResultsS20G‐IAPP expression was associated with a decrease in viability and an increase in terminal deoxynucleotidyl transferase‐mediated deoxyuridine triphosphate‐biotin nick end labeling‐positive cells in AtT‐20ins cells. Furthermore, downregulation of human insulin enhanced the cytotoxicity associated with S20G‐IAPP, and induced the cytotoxicity associated with wild‐type (WT)‐IAPP. Reduction of ubiquitin carboxy‐terminal hydrolase L1 activity enhanced cytotoxicity under the downregulation of human insulin expression in both S20G‐ and WT‐IAPP transduced cells. A 5‐year follow up of type 2 diabetic patients showed a disproportionate increase of serum fasting IAPP‐to‐insulin ratio from baseline.ConclusionsHuman insulin plays a protective role against the cytotoxicity associated with S20G‐IAPP, as well as WT‐IAPP. The findings could suggest long‐term deterioration of insulin secretion associates with IAPP linked cytotoxicity in type 2 diabetes.
Desmoplastic melanoma on the nose: electrochemotherapy as an alternative treatment to local advanced disease
Authors: Carrera C. , Bennassar A. , Ishioka P. , Dalle S. , Vilalta A. , Fuertes I. , Alos L. , Thomas L. , Puig S. , Malvehy J. 
Published: March 2013

AbstractBackgroundDesmoplastic malignant melanoma (DMM) is a rare and usually misdiagnosed type of melanoma. Delayed detection at complicated anatomical locations can lead to the necessity of alternative therapies.ObjectiveCharacterization of DMM on the nose, which is the second more frequent type of MM.MethodsReview of case series of eight pathologically proven DMM on the nose from two referral centres with a mean follow‐up of 69 ± 40.5 months.ResultsAccording to a single centre experience, there is a more than 70‐fold increased risk of having a DMM on the nose compared with a non‐DMM (P < 0.0005, CI99% 16.3–317.3). Clinical and pathological misdiagnoses were frequent, only three of the eight cases were properly diagnosed and treated and indeed they did not experience relapses. Due to non‐clinical suspicion and superficial biopsies, three cases were initially pathologically misdiagnosed as basal cell carcinomas and a nevus respectively. Atypical vessels and remnants of pigment on dermoscopy are indicative findings even in non‐pigmented cases. Although not significant, the mean disease‐free survival differed between cases with a correct initial management (four cases, 66.7 ± 57.3 months) in contrast to improper (four cases, 16.25 ± 18.9 months). Electrochemotherapy achieved a complete local control of disease in two cases unsuitable for surgery.ConclusionsUse of dermoscopy and correctly selected biopsy of lesions on the face is mandatory to improve early diagnosis of DMM. Improper management of challenging cases implies a more complicated therapy and loco‐regional invasion risk. Electrochemotherapy could be a promising therapy in local advanced tumours.
Vibrios in hatchery cultures of the razor clam, Solen marginatus (Pulteney)
Authors: Prado S , Dubert J , da Costa F , Martínez‐Patiño D , Barja J L 
Published: March 2013

AbstractHatchery culture of the razor clam, Solen marginatus (Pulteney), has recently been developed in Galicia (NW Spain). However, recurrent episodes of mortalities of larval and post‐larval cultures have been recorded during the course of various studies. The disease signs were similar to those described for other bivalve species in outbreaks caused by bacteria of the genus Vibrio. In this article, we present the results of microbiological monitoring of two batches of razor clams with different survival rates. All fermentative isolates were identified as members of the Splendidus clade within the genus Vibrio. Some of these isolates, identified as Vibrio splendidus‐like, were clearly associated with the batch suffering mortalities, indicating their possible role as pathogens. Similar strains were found in the broodstock, suggesting vertical transmission of these bacteria. This is the first study of the microbiota associated with hatchery culture of S. marginatus, and the results will provide useful information for the optimization of a protocol for hatchery culture of this bivalve species.
Endometriosis of the perineum
Authors: Nasu Kaei , Okamoto Mamiko , Nishida Masakazu , Narahara Hisashi 
Published: March 2013

AbstractEndometriosis of the perineum and vulva is extremely rare, with the most common site being episiotomy scars. We report here a case of spontaneously developing perineal endometriosis successfully treated with local excision. A 39‐year‐old woman was admitted complaining of a painful vulvar lump with cyclic swelling. She had first noticed the mass 7 years before, and it had gradually increased in size. Gynecological examination showed a walnut‐size, painful, subcutaneous mass in the left perineum. Magnetic resonance imaging revealed a multilobular cystic mass with inner hemorrhage, suggesting vulvar endometriosis. The patient was treated by local excision of the vulvar mass, and complete excision was achieved. The pathological diagnosis of the excised tissue was endometriosis. The patient is well without evidence of disease 5 months following the local excision. Spontaneous perineal and vulvar endometriosis is extremely rare. However, any lesion that evolves in response to the menstrual cycle should be considered endometriosis.
Can maternal serum placental growth factor estimation in early second trimester predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction? A prospective cohort study
Authors: Ghosh Sanjib Kumar , Raheja Shashi , Tuli Anita , Raghunandan Chitra , Agarwal Sneh 
Published: March 2013

AbstractAimTo determine whether maternal serum placental growth factor (PlGF) estimation in early second trimester (20–22 weeks of gestation) can predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction (IUGR).Material and MethodsA prospective cohort study was conducted on 722 women with singleton pregnancies, screened from the antenatal clinic, and serum PlGF levels were estimated at 20–22 weeks of gestation. A cut‐off value of <155 pg/mL for serum PlGF was determined by receiver operating characteristic (ROC) curve analysis for identifying pregnant women at risk of developing early onset preeclampsia and/or early onset IUGR. Preeclampsia and IUGR were classified as early onset when diagnosed by 32 weeks of gestation. Univariate logistic regression analysis was used to analyze the association between serum PlGF level <155 pg/mL and the two outcome measures (i.e. early onset preeclampsia and early onset IUGR) and odds ratio (OR) was computed. P‐value < 0.05 was considered statistically significant.ResultsMaternal serum PlGF level <155 pg/mL at 20–22 weeks of gestation had a strong association with early onset preeclampsia (OR 8.35; 95% CI 1.79–18.94; P = 0.007) and with early onset IUGR (OR 10.73; 95% CI 4.08–20.23; P = 0.000). The sensitivity of serum PlGF < 155 pg/mL for predicting early onset preeclampsia and early onset IUGR were 82 and 84, respectively.ConclusionMaternal serum PlGF level estimation in early second trimester (20–22 weeks of gestation) may be useful in predicting the occurrence of early onset preeclampsia and/or early onset IUGR.
Parasitic myomas after laparoscopic‐assisted myomectomy in multiple endocrine neoplasia type 1
Authors: Takeda Akihiro , Sakurai Akihiro , Imoto Sanae , Nakamura Hiromi 
Published: March 2013

AbstractMultiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary disorder that develops multiple tumors arising from various endocrine organs, including the parathyroid gland, endocrine pancreas and pituitary gland. Although mesenchymal tumors can be an integral part of the syndrome, parasitic peritoneal myomas have never been described in an MEN1 patient. Seven years after laparoscopic‐assisted myomectomy, parasitic peritoneal myomas were diagnosed in a 31‐year‐old woman with situs inversus totalis and previous history of parathyroid adenoma. Subsequently, MEN1 was clinically diagnosed by identification of endocrine pancreatic, adrenal and pituitary tumors. Genetic analysis revealed a heterozygous germline mutation in the splice donor sequence of intron 6 of the MEN1 gene. Although rare, parasitic peritoneal myomas could potentially be associated with MEN1 syndrome.
Prenatal diagnosis of right aortic arch with mirror‐image branching without associated anomalies
Authors: Nakata Masahiko , Suzuki Yasuo , Hotta Noriko , Sunasaka Takayo , Numa Fumitaka 
Published: March 2013

AbstractA pregnant woman at 32 weeks of gestation was referred because of untypical visualization of a three‐vessel tracheal view. Detailed ultrasound examination demonstrated an abnormal position of descending aorta, positioned at the right‐front side of the spine at the level of four‐chamber view. The descending aorta was connected with left pulmonary artery through ductus arteriosus, which configured a vascular ring. Right aortic arch with mirror‐image branching without any associated anomaly was suspected prenatally. Amniocentesis showed no chromosomal abnormality. A male, 2440‐g infant was delivered vaginally at 37 weeks and 4 days of gestation. Echocardiography confirmed no associated congenital heart defect. Three‐dimensional reconstruction using 64‐slice spiral computed tomography angiography at 2‐months old confirmed the diagnosis of right aortic arch with mirror‐image branching. The infant is now 1 year old and well developed without any symptoms.
Eating Patterns Among Students With Intellectual Disabilities After a Multifactorial School Intervention Using the Plate Model
Authors: Flygare Wallén Eva , Müllerdorf Maria , Christensson Kyllike , Marcus Claude 
Published: March 2013

AbstractAdolescents with intellectual disabilities (ID) have an increased prevalence of being overweight and having cardiometabolic diseases as adults, in part due to poor eating habits with an inadequate intake of vegetables. The aim of this study was to evaluate whether a multifactorial school intervention using the “Plate Model” results in improved healthy food choices with recommended ≥37.5% of vegetables. Participants with mild/moderate intellectual disabilities from an intervention school (n = 27) were compared with controls (n = 62) from two other upper secondary schools for students with ID. All were offered a test buffet lunch with meatballs, potatoes, sauce, and eight different vegetables presented in identical bowls. Their servings and food intake were evaluated from digital images and video films. The majority (88%) of the total group filled their plate with ≥37.5% of vegetables. The mean energy intake did not differ between the groups (576 kcal (min 196—max 1444)). The intervention participants had a lower intake of fat (21% (SD 6) vs. 24% (SD 7), p = .031), a higher intake of carbohydrates (57% (SD 7) vs. 53% (SD 8), p = .035), less plate waste (5 (SD 10) grams vs. 25 (SD 43) grams, p = .021), and more participants took only one portion (56% vs. 32%, p = .039) compared with the control group. The participants from the intervention school made healthier food choices. In this setting, most adolescents with ID ate a sufficient amount of vegetables.
Potential role of Alternaria and Cladosporium species in canine lymphoplasmacytic rhinitis
Authors: Mercier E. , Peters I. R. , Billen F. , Battaille G. , Clercx C. , Day M. J. , Peeters D. 
Published: March 2013

ObjectivesTo evaluate the possible role of Alternaria and Cladosporium species in the pathogenesis of canine lymphoplasmacytic rhinitis by comparing the amount of specific fungal DNA in nasal mucosal biopsies between dogs without nasal neoplasia and those with lymphoplasmacytic rhinitis or nasal neoplasia.MethodsQuantitative real‐time polymerase chain reaction (qPCR) assays detecting DNA from Alternaria and Cladosporium fungi were applied to nasal mucosal biopsies collected from dogs with lymphoplasmacytic rhinitis (n = 8), dogs with nasal neoplasia (n = 10) and control animals (n = 10). A copy number for each sample was calculated using a standard curve of known copy number and differences amongst groups were assessed using Kruskal–Wallis tests.ResultsNo significant difference was found between the groups. Low levels of Alternaria DNA (10–100 copies/PCR) were detected in one sample; very low levels of DNA (<10 copies/qPCR) were detected in 6 samples, and 21 samples were negative. Low levels of Cladosporium DNA were detected in 2 samples; very low levels of DNA in 18; and 8 were negative.Clinical SignificanceResults of this study reveal that Alternaria and Cladosporium species are part of the canine nasal flora, and that these fungi are probably not involved in the pathogenesis of lymphoplasmacytic rhinitis.