bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association ofRANandRANBP2Gene Polymorphisms With Glioma Susceptibility in Chinese Children
Authors: Lin Qianru , Chen Wei , Tan Jiating , Qian Sifan , Su Huarong , Zhao Liang , Yuan Li , Ruan Jichen , Huang Xiaokai , Zhou Haixia 
Published: July 2024

ABSTRACTBackgroundGlioma is the most prevalent pediatric central nervous system malignancy. RAN, member RAS oncogene family (RAN), is a key signaling molecule that regulates the polymerization of microtubules during mitosis. RAN binding protein 2 (RANBP2) is involved in DNA replication, mitosis, metabolism, and tumorigenesis. The effects ofRANandRANBP2gene polymorphisms on glioma susceptibility in Chinese children are currently unknown.AimsThis study aimed to evaluate the association betweenRANandRANBP2gene polymorphisms and glioma susceptibility in Chinese children.Methods and ResultsWe recruited 191 patients with glioma and 248 children without cancer for this case–control study. Polymerase chain reaction‐based TaqMan was applied to gene sequencing and typing. Logistic regression model‐calculated odds ratio and 95% confidence interval were used to verify whether the gene polymorphisms (RANrs56109543 C>T, rs7132224 A>G, rs14035 C>T, andRANBP2rs2462788 C>T) influence glioma susceptibility. Based on age, gender, tumor subtype, and clinical stage, stratified analyses of risk and protective genotypes were conducted.pvalues for mutant genotype analyses were all >0.05, indicating no significant correlation between these gene polymorphisms and glioma risk.ConclusionRANandRANBP2gene polymorphisms were not found to be statistically significantly associated with glioma susceptibility in Chinese children. Other potential functional gene polymorphism loci ofRANandRANBP2will need to be evaluated in the search for novel glioma biomarkers.
Association of Peri‐Implant Mucosa Dimensions With Emergence Profile Angles of the Implant Prosthesis
Authors: Rungtanakiat Piboon , Thitaphanich Natchaya , Janda Martin , Strauss Franz Josef , Arksornnukit Mansuang , Mattheos Nikos 
Published: July 2024

ABSTRACTObjectivesThe primary aim of this cross‐sectional study was to investigate the association between prosthesis design and peri‐implant mucosa dimensions and morphology. The secondary aim was to investigate associations between mucosal dimensions and the presence of mucositis.Materials and MethodsForty‐seven patients with 103 posterior bone level implants underwent clinical and radiographic examination, including cone beam computer tomography and intraoral optical scanning. Three‐dimensional models for each implant and peri‐implant mucosa were constructed. Vertical mucosa height (TH), horizontal mucosa width at implant platform (TW), and 1.5 mm coronal of the platform (TW1.5), as well as mucosal emergence angle (MEA), deep angle (DA), and total contour angle (TA) were measured at six sites for each implant.ResultsThere was a consistent correlation between peri‐implant mucosa width and height (β = 0.217, p < 0.001), with the width consistently surpassing height by a factor of 1.4–2.1. All three angles (MEA, DA, TA) were negatively associated with mucosa height (p < 0.001), while DA was negatively associated with mucosa width (TW1.5) (p < 0.001, β = −0.02, 95% CI: −0.03, −0.01). There was a significant negative association between bleeding on probing (BoP) and mucosa width at platform (OR 0.903, 95% CI: 0.818–0.997, p = 0.043) and 1.5 coronal (OR 0.877, 95% CI: 0.778–0.989, p = 0.033). Implants with less than half sites positive for BoP (0–2/6) had significantly higher mucosa height (OR 3.51, 95% CI: 1.72–7.14, p = 0.001).ConclusionsProsthesis design can influence the dimensions of the peri‐implant mucosa, with wider emergence profile angles associated with reduced peri‐implant mucosa height. In particular, a wider deep angle is associated with reduced mucosa width in posterior sites. Reduced peri‐implant mucosa height and width are associated with more signs of inflammation.Trial RegistrationRegistered in Thai Clinical Trials Registry: http://www.thaiclinicaltrials.org/show/TCTR20220204002.
Favored Amorphous LixSi Process with Restrained Volume Change Enabling Long Cycling Quasi‐Solid‐State SiOx anode
Authors: Wang Ruoyang , Wu Yuqing , Niu Yifan , Yang Qing , Li Haoyu , Chen Ting , Song Yang , Zhong Benhe , Wu Zhenguo 
Published: July 2024

AbstractSilicon‐based anodes are becoming promising materials due to their high specific capacity. However, the intrinsically large volume change brought about by the alloying reaction results in the crushing of the active particles and destruction of the electrode structure, which severely limits its practical application. Various structured and modified silica‐based anodes exhibit improved cycling stability and the demonstrated ability to mitigate their volume changes through interfacial and binder strategies. However, the issue of large volume changes in silicon‐based anodes remains. Herein, we report a gel polymer electrolyte (GPE) prepared through an in situ thermal polymerization process that is suitable for SiOx anode materials and achieving long‐term cycling stability. GPE‐based cells essentially mitigate the volume change of SiOx anodes by guiding the unique lithiation/delithiation mechanism that tends to favor the formation and delithiation of amorphous‐LixSi (a‐LixSi) with smaller volume change, thereby mitigating electrode damage and cracking, and achieving the significant improvement in cycling performance. The prepared GPE‐SiOx cells retained 693.80 mAh g−1 reversible capacity after 450 cycles at 500 mA g−1. In addition, the prelithiation process was incorporated to mitigate capacity fluctuations and improve the Initial Coulombic Efficiency (ICE), and a reversible capacity of 641.90 mAh g−1 was retained after 480 cycles.
Multi‐band pass negative group delay circuit with low insertion loss
Authors: Chang Niannan , Yuan Aixia , Wang Ying , Liu Junzheng 
Published: July 2024

AbstractA novel multi‐band pass negative group delay circuit has been designed and proposed. The circuit consists of three types of components: capacitance, inductance, and resistance. An n‐order bandpass negative group delay circuit was analyzed and presented, and taking a three‐frequency bandpass negative group delay circuit as an example, the influence of different component values on the circuit group delay and insertion loss was analyzed. The actual test results of this circuit are consistent with the simulation results, and it can achieve the function of a multi‐bandpass circuit. In actual testing, the circuit frequencies with negative group delay are 49, 82, and 102 MHz, with corresponding group delay values of −2.177, −2.058, and −1.903 ns and corresponding insertion loss values of −5.810, −5.835, and −5.866 dB.
LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53‐driven tumour progression through miR‐5683/FGF2
Authors: Liu Nannan , Jiang Xinxiu , Zhang Ge , Long Shuaiyu , Li Jiehan , Jiang Meimei , Jia Guiyun , Sun Renyuan , Zhang Lingling , Zhang Yingjie 
Published: July 2024

AbstractN‐methyladenosine (m6A) represents a prevalent RNA modification observed in colorectal cancer. Despite its abundance, the biological implications of m6A methylation on the lncRNA CARMN remain elusive in colorectal cancer, especially for mutant p53 gain‐of‐function. Here, we elucidate that CARMN exhibits diminished expression levels in colorectal cancer patients with mutant p53, attributed to its rich m6A methylation, which promotes cancer proliferation, invasion and metastasis in vitro and in vivo. Further investigation illustrates that ALKBH5 acts as a direct demethylase of CARMN, targeting 477 methylation sites, thereby preserving CARMN expression. However, the interaction of mutant p53 with the ALKBH5 promoter impedes its transcription, enhancing m6A methylation levels on CARMN. Subsequently, YTHDF2/YTHDF3 recognise and degrade m6A‐modified CARMN. Concurrently, overexpressing CARMN significantly suppressed colorectal cancer progression in vitro and in vivo. Additionally, miR‐5683 was identified as a direct downstream target of lncRNA CARMN, exerting an antitumour effect by cooperatively downregulating FGF2 expression. Our findings revealed the regulator and functional mechanism of CARMN in colorectal cancer with mutant p53, potentially offering insights into demethylation‐based strategies for cancer diagnosis and therapy. The m6A methylation of CARMN that is prime for mutant p53 gain‐of‐function‐induced malignant progression of colorectal cancer, identifying a promising approach for cancer therapy.
Steroid lifting method during endoscopic submucosal dissection: A novel strategy for stricture prevention
Authors: Omae Masami , Maltzman Henrik , Vujasinovic Miroslav , Wang Naining , Baldaque‐Silva Francisco 
Published: July 2024

AbstractA 73‐year‐old male patient was referred to us with a long Barrett's esophagus (BE). He had a history of pulmonary embolism under anticoagulant therapy. Esophagogastroduodenoscopy showed a C8M9 BE with no macroscopic lesions. Random biopsies from the BE revealed multifocal high‐grade dysplasia. The case was discussed in a multidisciplinary team conference and the decision for full resection of BE with endoscopic submucosal dissection (ESD) was made. Considering the large ESD resection and the high risk of stricture, we developed a novel preventive technique: the “steroid lifting method” for submucosal injection during ESD. Complete circumferential ESD with en bloc resection was performed using the “steroid lifting method”, without adverse events. Oral liquids were initiated on day 1 and the patient was discharged on day 4. Oral prednisolone (30 mg per day) was started and tapered for a total of 6 weeks. The pathological examination confirmed multifocal high‐grade dysplasia, with radical and curative resection. The patient had neither stricture, dysphagia nor recurrence of Barrett's mucosa at the 2, 6, 12, and 24‐month follow‐up. International guidelines recommend oral prednisolone and triamcinolone injection to prevent stricture formation in large ESD of esophageal squamous cell carcinoma. However, there is no solid data on BE ESD. The risk factors for stricture formation and the optimal preventive management after large BE ESD is not known. The “steroid lifting method” might be an option in this context. Large prospective studies addressing stricture formation and preventive measures on BE ESD are necessary.
Marginal inference for hierarchical generalized linear mixed models with patterned covariance matrices using the Laplace approximation
Authors: Ver Hoef Jay M. , Blagg Eryn , Dumelle Michael , Dixon Philip M. , Zimmerman Dale L. , Conn Paul B. 
Published: July 2024

AbstractWe develop hierarchical models and methods in a fully parametric approach to generalized linear mixed models for any patterned covariance matrix. The Laplace approximation is used to marginally estimate covariance parameters by integrating over all fixed and latent random effects. The Laplace approximation relies on Newton–Raphson updates, which also leads to predictions for the latent random effects. We develop methodology for complete marginal inference, from estimating covariance parameters and fixed effects to making predictions for unobserved data. The marginal likelihood is developed for six distributions that are often used for binary, count, and positive continuous data, and our framework is easily extended to other distributions. We compare our methods to fully Bayesian methods, automatic differentiation, and integrated nested Laplace approximations (INLA) for bias, mean‐squared (prediction) error, and interval coverage, and all methods yield very similar results. However, our methods are much faster than Bayesian methods, and more general than INLA. Examples with binary and proportional data, count data, and positive‐continuous data are used to illustrate all six distributions with a variety of patterned covariance structures that include spatial models (both geostatistical and areal models), time series models, and mixtures with typical random intercepts based on grouping.
Microwave‐sintered mullite structural ceramics based on low‐grade bauxite applied for fracturing proppants
Authors: Li Xiaogang , Xiong Junya , Yang Zhaozhong , Zhu Jinyi , Li Weizhe 
Published: July 2024

AbstractThis study aimed to assess the feasibility of manufacturing fracturing proppants by microwave sintering and using low‐grade bauxite as raw material. The effects of microwave hotspot SiC and sintering additive MnO2 content on the performance of the mullite‐based structural materials were studied, respectively. The optimum sintering condition was determined by single‐factor experiments. The sintering process and mechanism were explored based on the analysis of physicochemical properties, phase transitions, and microstructure. The results showed that (1) mullite ceramic composites could be successfully prepared only with SiC added and with poor interparticle bonding microstructure. (2) With the addition of MnO2 and CaO, the granular‐shaped mullite crystals transformed into rod‐like mullite crystals, forming a net structure. (3) As the input power increased, the overfast sintering rate would reduce proppants' mechanical properties, and it was also necessary to select a reasonable sintering time to avoid overburning. (4) When the mass ratio of MnO2:CaO:SiC:bauxite was 2:1.5:12:84.5 and under the sintering condition of 1000 W, 2 h, the performance (breakage ratio of 8.5% under 28 MPa closed pressure, apparent density of 2.58 g/cm3, turbidity of 52 FTU, and acid solubility of 6.77%) could meet the requirements of the Chinese Petroleum and Gas Industry Standard (SY/T 5108–2014). This study provides a powerful way for reducing the fracturing cost, which not only improves the low‐grade bauxite utilization scale within the ceramic industry, but also expands the application of microwave sintering technology in mullite structural materials for the petroleum and gas industry.
A policy option towards improving efficiencies in Victorian public oral healthcare
Authors: Nguyen Tan Minh , Hall Martin 
Published: July 2024

AbstractBackgroundInternational oral health policy directions led by the World Health Organisation call for the inclusion of oral health within universal health coverage. The aim of this study is to perform a budget impact analysis of a policy option for a more cost‐efficient oral health workforce skill‐mix (dentists and oral health therapists) to provide public oral healthcare in Victoria, Australia.MethodsTwo hypothetical standard care pathways were developed. A dynamic population Markov model in TreeAge software, with a time horizon of 6 years. Two scenarios were modelled to determine: (1) base‐case scenario: the threshold the dentist workforce could reduce per year, while achieving the same service delivery outputs, and (2) alternative scenario: the potential cost‐savings for utilising an optimally cost‐efficient oral health workforce skill‐mix.ResultsThe threshold analysis showed a minimum reduction of 13% of the dentist workforce being replaced with oral health therapists can occur without having any impact on the same service delivery outputs. Under the alternative scenario, the potential cost‐savings would be AUD$1,425,037 (standard deviation 58,954).ConclusionsGovernments and policy‐decision makers should consider strategies in training, attracting, and retaining oral health therapists to achieve an optimally cost‐efficient oral health workforce skill‐mix when delivering public oral healthcare.
Healthcare quality improvement: It's time to update the Donabedian approach with a complex systems perspective
Authors: Geary Una 
Published: July 2024

AbstractThere is broad consensus that healthcare systems are complex systems, which as a result, face complex problems. From this perspective, quality of care can be conceptualised as an emergent outcome of the healthcare system, that is more than the sum of individual components of care (in terms of inputs and processes), and quality improvement as a complex systems problem. However, traditional approaches, such as Donabedian's structure/process/outcome framework, are rooted in a linear, reductionist perspective, that fails to recognise that quality of care is created in the context of complex healthcare systems, and the many interactions and uncertainties at play that shape quality of care and health outcomes. A paradigm shift is needed from a reductionist to a systems thinking approach if we are to better understand and improve quality of care. Such a shift begins with asking different research questions, situated within the system context, that focus on identifying how interventions may contribute to system improvement, as opposed to seeking to directly link interventions with quality of care outcomes. In contrast to traditional healthcare quality measures focusing on single components of the system in isolation, research needs to explicitly consider quality of care as an emergent system outcome and identify new indicators and methods of assessment that provide insight into how the healthcare system functions as an interconnected whole. It is an opportune moment to harness the energy of the international healthcare quality movement to drive the innovation needed in research and practice to adopt a systems thinking approach.
Sustainability assessment of denim fabric made of PET fiber and recycled fiber from postconsumer PET bottles using LCA and LCC approach with the EDAS method
Authors: Fidan Fatma Şener , Aydoğan Emel Kızılkaya , Uzal Niğmet 
Published: July 2024

Abstract
The textile industry is under pressure to adopt sustainable production methods because its contribution to global warming is expected to rise by 50% by 2030. One solution is to increase the use of recycled raw material. The use of recycled raw material must be considered holistically, including its environmental and economic impacts. This study examined eight scenarios for sustainable denim fabric made from recycled polyethylene terephthalate (PET) fiber, conventional PET fiber, and cotton fiber. The evaluation based on the distance from average solution (EDAS) multicriteria decision-making method was used to rank scenarios according to their environmental and economic impacts, which are assessed using life cycle assessment and life cycle costing. Allocation, a crucial part of evaluating the environmental impact of recycled products, was done using cut-off and waste value. Life cycle assessments reveal that recycled PET fiber has lower freshwater ecotoxicity and fewer eutrophication and acidification impacts. Cotton outperformed PET fibers in human toxicity. Only the cut-off method reduces potential global warming with recycled PET. These findings indicated that recycled raw-material life cycle assessment requires allocation. Life cycle cost analysis revealed that conventional PET is less economically damaging than cotton and recycled PET. The scenarios were ranked by environmental and economic impacts using EDAS. This ranking demonstrated that sustainable denim fabric production must consider both economic and environmental impacts. Integr Environ Assess Manag 2024;20:2347–2365. © 2024 The Author(s). Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Key Points
This study investigated denim fabrics produced using recycled polyethylene terephthalate (PET) fiber instead of virgin cotton and conventional PET fiber in eight scenarios. The life cycle cost (LCC), life cycle assessment (LCA), and evaluation based on distance from average solution methodologies were used to analyze, and a sensitivity analysis was performed to assess LCA uncertainty. Using recycled PET with the cut-off method instead of cotton resulted in positive environmental outcomes across most categories, indicating a significant reduction in impacts such as global warming, stratospheric ozone depletion, and ionizing radiation. Using recycled PET with the waste valuation method often leads to more negative outcomes than the cut-off method, suggesting that the allocation method plays a crucial role in determining the environmental benefits of recycled materials.
HCN: Hybrid Capsule Network for Fetal Plane Classification in Ultrasound Images
Authors: Tanwar Sourav Kumar , Choudhary Prakash , Priyanka  , Agrawal Tarun 
Published: July 2024

ABSTRACTClassifying fetal ultrasound images into different anatomical categories, such as the abdomen, brain, femur, thorax, and so forth can contribute to the early identification of potential anomalies or dangers during prenatal care. Ignoring major abnormalities that might lead to fetal death or permanent disability. This article proposes a novel hybrid capsule network architecture‐based method for identifying fetal ultrasound images. The proposed architecture increases the precision of fetal image categorization by combining the benefits of a capsule network with a convolutional neural network. The proposed hybrid model surpasses conventional convolutional network‐based techniques with an overall accuracy of 0.989 when tested on a publicly accessible dataset of prenatal ultrasound images. The results indicate that the proposed hybrid architecture is a promising approach for precisely and consistently classifying fetal ultrasound images, with potential uses in clinical settings.
Hepatic enzyme induction and its potential effect on thyroid hormone metabolism in the metamorphosing tadpole of Xenopus laevis (African clawed frog)
Authors: Wada Kohei , Yamaguchi Takafumi , Tanaka Hitoshi , Fujisawa Takuo 
Published: July 2024

AbstractHepatic enzyme induction, an inherent defense system against xenobiotics, is known to simultaneously affect endocrine system functions in mammals under specific conditions, particularly thyroid hormone (TH) regulation. While this phenomenon has been studied extensively, the pathway leading to this indirect thyroid effect in mammals has unclear applicability to amphibians, despite the importance of amphibian species in assessing thyroid‐disruptive chemicals. Here, we investigated the effects of three well‐known mammalian enzyme inducers—β‐naphthoflavone (BNF), pregnenolone carbonitrile (PCN), and sodium phenobarbital (NaPB)—on the gene expression of phase‐I and phase‐II metabolizing enzymes in Xenopus laevis tadpoles. Waterborne exposure to BNF and PCN significantly induced the expression of both phase‐I (cytochrome P450, CYP) and phase‐II enzymes (UDP‐glucuronosyltransferase, UGT and sulfotransferase, SULT), but in different patterns, while NaPB exposure induced CYP2B expression without affecting phase‐II enzymes in tadpoles, in contrast to mammals. Furthermore, an ex vivo hepatic enzyme activity assay confirmed that BNF treatment significantly increased phase‐II metabolic activity (glucuronidation and sulfation) toward TH. These results suggest the potential for certain mammalian enzyme inducers to influence TH clearance in X. laevis tadpoles. Our findings provide insights into the profiles of xenosensing activity and enzyme induction in amphibians, which can facilitate a better understanding of the mechanisms of indirect effects on the thyroid system via hepatic enzyme induction in nonmammalian species.