bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer
Authors: Shanahan Sean-Luc , Kunder Nikesh , Inaku Charles , Hagan Natalie B , Gibbons Grace , Mathey-Andrews Nicolas , Anandappa Gayathri , Soares Shawn , Pauken Kristen E , Jacks Tyler , Schenkel Jason M 
Published: July 2024

Abstract
Anticancer immunity is predicated on leukocyte migration into tumors. Once recruited, leukocytes undergo substantial reprogramming to adapt to the tumor microenvironment. A major challenge in the field is distinguishing recently recruited from resident leukocytes in tumors. In this study, we developed an intravascular Ab technique to label circulating mouse leukocytes before they migrate to tissues, providing unprecedented insight into the kinetics of recruitment. This approach unveiled the substantial role of leukocyte migration in tumor progression using a preclinical mouse model of lung adenocarcinoma. Regulatory T cells (Tregs), critical mediators of immunosuppression, were continuously and rapidly recruited into tumors throughout cancer progression. Moreover, leukocyte trafficking depended on the integrins CD11a/CD49d, and CD11a/CD49d blockade led to significant tumor burden reduction in mice. Importantly, preventing circulating Treg recruitment through depletion or sequestration in lymph nodes was sufficient to decrease tumor burden, indicating that Treg migration was crucial for suppressing antitumor immunity. These findings underscore the dynamic nature of the immune compartment within mouse lung tumors and demonstrate the relevance of a temporal map of leukocyte recruitment into tumors, thereby advancing our understanding of leukocyte migration in the context of tumor development.
Comprehensive Screening and Evaluation of Anti-gout Activity of Plantago asiatica L. through Integrated In vivo and In vitro Methodologies
Authors: Gao Hong-Xue , Liu Zhi-Qiang , Hou Zong , Song Feng-Rui , Xing Jun-Peng , Zheng Zhong , Liu Shu 
Published: July 2024

Objective:
This study aimed to elucidate the active components and mechanisms of Plantago asiatica L. (PAL) in the treatment of gout.

Materials and Methods:
Based on its polarity, PAL was partitioned into three parts, P1, P2, and P3, through gradient elution using AB-8 macroporous resin columns. The primary constituents of these fractions include iridoids, phenylethanoid glucosides, and flavonoids. Subsequently, a comprehensive in vitro and in vivo screening and evaluation model was developed considering the fundamental pathological processes of gout, including the inhibition of uric acid (UA) production, augmentation of UA excretion, and anti-inflammatory effects. This model was used to analyze the anti-gout activity of P1, P2, P3, and the overall extracts derived from PAL.

Results:
All the PAL parts exhibited specific therapeutic properties as part of gout therapy. Specifically, the P2 part demonstrated the ability to diminish interleukin-1 beta levels, lower UA concentrations, suppress joint inflammation in rats, and restore abnormal parameters associated with gout, such as creatinine and urea nitrogen. These findings highlight the significant effect of P2 on gout treatment.

Conclusions:
Following a thorough assessment of the outcomes derived from diverse anti-gout experiments, P2 exhibited superior anti-gout properties compared to the remaining parts. P2 demonstrated a restorative effect on the aberrant parameters associated with gout, thereby comprehensively elucidating the therapeutic mechanism of P2 against gout. This study provides substantial evidence and serves as a reference for future investigations regarding the material foundation of PAL in gout treatment.
EFFECT OF DE-TOPPING ON VARIOUS DATES OF GROWTH PARAMETERS OF PEACH NURSERY PLANTS
Authors: Ali Yasir 
Published: July 2024

The research study was carried out to examine the effect of de-topping parameters of peach nursery plant. The experiment layout was Randomized Complete Block Design (RCBD) at “Nuclear Institute for Food and Agriculture Peshawar” (NIFA) Research Farm during the year 2021. On different dates de-topping were practiced (24 June, 30 June, 6 July and 12 July). The data revealed that the de-topping practice on 6 July showed significant results on days to sprout (65.33), bud success Percentage (94.83 %), number of leaves (251), number of branches (22) and internode length (7.36 cm), while practicing of de-topping on 12 July found better results in plant height (59.66 cm). The minimum results showed in days to sprout (54), bud Success percentage (94.64), plant height (32.33 cm) and number of leaves (225.67) which were de-topped on 24 July. Hence for better bud take success on peach rootstock the de-topping were practice on 6 July is recommended.
RECONSIDERING THE USE OF POST-POSITIVIST PARADIGM IN SOCIAL SCIENCES: IS IT POSSIBLE?
Authors: Musa Mohamad , Aldiabat Khaldoun 
Published: July 2024

This paper investigates the evolving landscape of research methodologies in the social sciences, focusing on the renewed interest in post-positivism amid growing dissatisfaction with strictly quantitative approaches. The study traces the experiences of a junior social work researcher struggling with paradigm identification, ultimately finding alignment with the adaptable and inclusive nature of post-positivism. By highlighting post-positivism's shift from a rigid quest for absolute truths to an emphasis on interactive dialogue and continuous learning, this research enriches the methodological discourse. The examination of post-positivism’s nuanced ontological, epistemological, and axiological perspectives underscores the significance of reflexivity and critical engagement in research. The study advocates for integrating qualitative and quantitative methods within the post-positivist paradigm to address complex social issues more effectively. It emphasizes the pivotal role of junior researchers in contributing to paradigm discussions and advancing the field, particularly in the scholarship of teaching and learning. By revisiting the post-positivist paradigm, this research encourages graduate students and emerging scholars to critically examine and understand the epistemological foundations that shape knowledge production. This exploration not only enriches their research but also equips them with essential skills for engaging with varied perspectives and advancing scholarly discourse.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0777/a.php" alt="Hit counter" /></p>
Vol. 5, N.º 2, Jul-Dez 2024 - "Ecografia - A Nova Fronteira para Técnicos de Radiologia"
Authors: Editorial Conselho 
Published: July 2024

Nona publicação da ROENTGEN - Revista Científica das Técnicas Radiológicas, com especial destaque para a temática "Ecografia - A Nova Fronteira para Técnicos de Radiologia".
Este número da ROENTGEN visa sensibilizar tanto profissionais quanto estudantes das Técnicas Radiológicas para a importância de abraçar os Novos Horizontes Ecográficos. A ecografia não é apenas uma ferramenta de diagnóstico; é uma porta aberta para um futuro onde os Técnicos de Radiologia desempenham um papel ainda mais central e ativo na prestação de cuidados de saúde de qualidade.
Zumbido e hipertensão arterial: uma revisão sistemática
Authors: Goulart Isadora Medrado , Nery Vitor Nunes Santana , Sá Natália Maria Dias de , Melo Matheus Ribeiro 
Published: July 2024

Introdução: O zumbido, uma percepção auditiva ou sensação sonora não relacionada ao estímulo externo, é considerado, em sua maioria, um sintoma multifatorial. A análise detalhada relaciona essa afecção com possíveis etiologias, sintomas subjetivos e enfermidades coexistentes. Objetivo: Este artigo, uma revisão sistemática, tem por objetivo relacionar essa ilusão com uma comorbidade prevalente, a hipertensão arterial sistêmica, na busca por possíveis relações entre elas. Materiais, sujeitos e métodos: Para a elaboração deste artigo de revisão de literatura foram consultados artigos científicos de revisão publicados e referenciados nas plataformas Lilacs, Medline e Pubmed entre 2005 e 2024. Resultados e discussões: Considerando que esse sintoma se relaciona a diversos fatores, seu estudo necessita de anamnese e exame clínico detalhados, além de exames complementares a fim de relacionarem-se às implicações da hipertensão arterial, que influenciarão na abordagem terapêutica. Considerações finais: Dois fatores devem ser considerados, sendo o primeiro deles o fator subjetivo do zumbido, dificultando a avaliação médica; e o segundo, a insuficiência de evidências sobre o tema, distanciando-se de um desfecho favorável e resolutivo.
Tratamento de granulomas laríngeos pós-intubação: revisão sistemática e metanálise proporcional
Authors: Lorena Sthefane Lemes , Gonçalves Larissa Abrão Lucante , Miranda Maria Mariana Vitório , Araujo Rocio Cristal Enciso , Santos Ana Cláudia Freitas 
Published: July 2024

Introdução: O granuloma laríngeo é uma lesão de contato formada de tecido de granulação no terço posterior das cordas vocais, decorrente de um processo inflamatório que surge após trauma e irritação crônica. Dentre as etiologias traumáticas, intubação e uso prolongado do tubo endotraqueal são as mais comuns. Objetivo: O presente artigo tem por objetivo verificar na literatura os principais tratamentos de granulomas laríngeos pós-intubação. Materiais, sujeitos e métodos: Para a elaboração deste artigo de revisão foram consultados artigos científicos e artigos de revisão publicados e referenciados nas plataformas de dados BVS, Scielo e Pubmed. Resultados e discussão: O tempo para resolução dos granulomas, realizando um tratamento cirúrgico, é o mais rápido dentre todos,visto que resolve imediatamente, apesar de muitos casos precisarem de tratamento clínico, para evitar recidivas. Já a budesonida inalatória é o tratamento que levou um maior tempo médio para a resolução da lesão, e deve ser considerada nas opções para o tratamento de granulomas laríngeos, já que apresenta baixa morbidade. Considerações finais: O estudo permite concluir que as opções de tratamento mais indicadas são conservadoras, com inibidores da bomba de prótons (IBP), glicocorticóides, fonoaudiologia, toxina botulínica, mitomicina C. Caso haja falha terapêutica, cirurgia à laser de CO2 ou instrumentos frios são opções.
Urticária colinérgica associada a hipohidrose generalizada adquirida: 2 casos clínicos e revisão da literatura
Authors: Melo Paullini Maria Gomes , Kyriakidis Nikole Vieira , Sanzovo Giulia D’Alessandro , Rosa Natasha Ohana Marinho 
Published: July 2024

Introdução: A Urticária colinérgica (UC) é uma patologia comum, caracterizada pela presença de pápulas eritematosas, pruriginosas, que são desencadeadas por alterações de temperatura corporal, estresse físico e emocional, bem como consumo de alimentos picantes. Objetivo: Fornecer uma revisão completa da literatura atual sobre urticária colinérgica associada à hipohidrose generalizada adquirida, enfatizando explorar os aspectos fisiopatológicos, diagnósticos e terapêuticos, contribuindo para um manejo clínico mais abrangente e eficaz. Materiais e métodos: Para a elaboração deste artigo de revisão foram consultados artigos científicos e artigos de revisão publicados e referenciados na Medline/PubMED, SciELO e Cochrane Library entre 2005 e 2017, disponíveis na língua inglesa, espanhola e portuguesa. Resultados e discussão: há íntima relação descrita entre ambas as condições. Existem dois subtipos de Urticária Colinérgica, uma delas envolve essa gênese com a Hipohidrose e, também, com os receptores de acetilcolina. O que ocorre é que as células epiteliais das glândulas sudoríparas écrinas não possuem expressão do receptor colinérgico M3; isto resulta na ausência de receptores colinérgicos em áreas anidróticas e expressão mínima em áreas hipoidróticas. Considerações finais: A exploração contínua da inter-relação entre urticária colinérgica e hipoidrose generalizada adquirida é essencial para avançar no cuidado clínico e no bem-estar dos pacientes afetados. A condução de estudos clínicos robustos e pesquisas translacionais é vital para traduzir esses avanços em benefícios tangíveis para a comunidade médica e os pacientes.
Using Indirect Speech Acts and Their Impacts on Creating a Conducive Workplace Environment
Authors: Hidayahni Amin Fatimah , Luhriyani Seny , Puji Rahayu Sri , Syukri Muhammad , Melati Amir Rahma 
Published: July 2024

Communication at the workplace requires meaningful understanding because it affects the work relationship as well as the work atmosphere. Hence, expressions used to generate such conditions are supposed to embody a conducive environment. This research aimed to determine the types of indirect speech acts and their language functions. This study used a qualitative research with a descriptive design to depict the phenomenon. The subjects were three employees at PT. Bosowa Berlian Motor Makassar, who were chosen purposively considering their availability and their readiness during the data collection. The data were collected by using observation with audio recordings and the researchers themselves as the non-participant observers. The results of this study showed that there were five types of indirect speech acts and there were certain language functions practiced by the employees, they are: emphasizing and instructing (assertive type), telling a condition and commanding what to do (directive type), directing and checking for the appropriate work (commissive type), complaining and giving subtle offense (expressive type), and responding, telling information and encouraging (declarative type). All types and their functions revealed and occurred to meet the need of creating a conducive environment in the workplace. The five types represent the traits of being assertive, directive, trusted, expressive, and declarative along with their use of language functions. These traits bear positive and good atmosphere in the workplace. Thus, with the conducive working environment, the employees can undertake their tasks well and focus on reaching the target in the workplace.
Pengaruh Pembiayaan Musyarakah, Mudharabah dan Murabahah Terhadap Profitabilitas Bank Umum Syariah di Indonesia
Authors: Paul Usmany  
Published: July 2024

Salah satu keberhasilan bank dalam menghasilkan laba setiap periodenya dapat dilihat dari profitabilitas suatu bank yang diukur menggunakan Return On Assets (ROA). Salah satu fenomena yang terjadi di perbankan syariah adalah profitabilitas perbankan syariah. Pada penelitian ini, penelitian ini menggunakan jenis penelitian kuantitatif. Penelitian kuantitatif merupakan penelitian yang berdasarkan data berupa angka-angka. Ruang lingkup pada penelitian ini terdiri dari variabel bebas (X) yakni pembiayaan mudharabah, musyarakah, dan murabahah dan variabel terikat (Y) yakni profitabilitas yang diukur dengan ROA (Return On Assets). Populasi yang digunakan pada penelitian ini adalah Bank umum syariah yang terdaftar di Bursa Efek Indonesia (BEI) periode 2020 hingga 2023 Metode pengambilan sampel yaitu dengan menggunakan non-probability sampling. Hasil penelitian telah menemukan bahwa Pembiayaan Musyarakah, Mudharabah dan Murabahah berpengaruh terhadap Profitabilitas Bank Umum Syariah di Indonesia.
Under the "Dual-Carbon" Goal: Green Credit Policy and High-quality Enterprise Development in China
Authors: Xu Lili , Li Chang , Zhang Xinxin , Zhao Xu 
Published: July 2024

Given the context of "carbon peaking" and "carbon neutrality" goals, advancing the growth of green finance stands as a crucial agenda to bolster the high-quality advancement of China's economy in the contemporary epoch. Green credit is a remarkable milestone in pursuing the "Dual-carbon" emissions reduction objective and promoting high-quality development. Empirically, scant information exists regarding the correlation between GCP and the high-quality development of heavily polluting enterprises (HPEs). Using panel data from Chinese Lushan A-share listed enterprises spanning 2005 to 2022, this study employs the difference-in-difference model to evaluate the impact of the green credit policy (GCP) on HPEs. Our results show that after the implementation of GCP, the high-quality development of HPEs increased by 9.08% compared to non-HPEs. Despite considering multiple potential confounding factors, the conclusion remains unchanged. The positive effect is particularly pronounced among non-state-owned enterprises characterized by high carbon emissions and in the eastern region. The mechanism analysis indicates that GCP plays a role in influencing the high-quality development of enterprises by promoting low-carbon technological progress. This study establishes a foundation for making informed decisions in optimizing the green financial policy system to effectively enhance the high-quality development of enterprises in China and other developing countries.

Received: 23 February 2024 | Revised: 17 May 2024 | Accepted: 12 July 2024

Conflicts of Interest
The authors declare that they have no conflicts of interest in this work.

Data Availability Statement
Data available on request from the corresponding author upon reasonable request.

Author Contribution Statement
Lili Xu: conceptualization, Methodology, Software, Formal analysis, Writing - review & editing, Visualization, Project administration. Chang Li: Methodology, Validation, Formal analysis, Investigation, Data curation, Writing - original draft. Xinxin Zhang: Conceptualization, Resources, Writing - review & editing, Supervision, Funding acquisition. Xu Zhao: Conceptualization, Resources, Writing - review & editing, Supervision, Funding acquisition.
Facilitators of and Barriers to Caregiver Adherence to Home Therapy Recommendations for Infants and Children With Neuromotor and Neuromuscular Diagnoses: A Scoping Review
Authors: Wingrat Jennifer , Price Carrie , Wright Tess 
Published: July 2024

Abstract
Importance: Caregiver-performed home therapy programs are essential to occupational therapy intervention for infants and children with neuromotor and neuromuscular diagnoses. Factors that facilitate or are barriers to caregiver adherence when making home therapy recommendations should be considered.
Objective: To identify facilitators of and barriers to caregiver adherence to home therapy recommendations for children with neuromotor and neuromuscular disorders.
Method: The review followed the five-step methodological framework developed by Arksey and O’Malley (2005) and was guided by the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews.
Data Sources: Searches with no language or date range limits were performed in MEDLINE, CINAHL Plus with Full Text, PsycINFO, and SocINDEX on the EBSCO platform, and Scopus on the Elsevier platform from database inception through January 24, 2023.
Study Selection and Data Collection: Study inclusion criteria included caregiver adherence to home therapy recommendations for children with neuromotor and neuromuscular diagnoses. Eight hundred seventy-five articles underwent title and abstract screening; 64 articles met the criteria for full review.
Findings: Twelve articles met the inclusion criteria. Four used qualitative measures, 7 used quantitative measures, and 1 used mixed methods. Qualitative thematic analysis revealed four facilitators: routine, efficacy of caregiver education, positive relationship with therapist, and perceived benefit of treatment. The analysis revealed three barriers: lack of time, lack of confidence, and caregiver stress.
Conclusions and Relevance: The facilitators and barriers identified are central to best-practice occupational therapy. Therapists can use expertise in analyzing routines and context to maximize the fit between family needs and home therapy recommendations.
Plain-Language Summary: Home therapy for children with a neuromotor and neuromuscular diagnosis is common and uses some form of caregiver-performed movement activities or techniques. To support caregivers, occupational therapists need to understand what factors facilitate or serve as barriers to following home therapy recommendations. The review found three barriers: lack of time, lack of confidence, and caregiver stress. The review provides strategies to support home therapy based on core principles of occupational therapy practice. It also identifies the need for more research to support home therapy recommendations that fit within the child’s and family’s routine, that can be taught in a way that meets the child’s and family’s learning needs, that facilitate self-efficacy and confidence, and that reflect the values and motivators of all participants.
O ENSINO DE GEOGRAFIA NAS SÉRIES INICIAIS DO ENSINO FUNDAMENTAL- REVISÃO BIBLIOGRÁFICA
Authors: Reis João Paulo Carneiro dos , Braz Nayanny Bruno de Oliveira , Reis Iracema Eulália Carneiro dos 
Published: July 2024

O propósito deste estudo é conduzir uma revisão bibliográfica sobre o ensino de geografia nos primeiros anos do ensino fundamental, com o intuito de investigar e sugerir estratégias educacionais que estimulem uma aprendizagem significativa e integrada. A discussão em questão se faz necessária devido à relevância do estudo da geografia no contexto do ensino fundamental. Por meio dele, as crianças são estimuladas a investigar e compreender as interações entre a sociedade e o meio ambiente, bem como a diversidade cultural. Por último, almeja-se responder às seguintes questões, como podemos garantir que o ensino de geografia nessas séries não se limite a transmitir informações sobre localização e características físicas, mas também estimule o pensamento crítico, a consciência ambiental e a compreensão das distintas realidades sociais? Em síntese, a formação contínua e o investimento na capacitação de professores e em políticas educacionais que promovam uma abordagem integrada e interdisciplinar no ensino de geografia detém uma relevância significativa para os professores de geografia das séries iniciais.
140-year daily ensemble streamflow reconstructions over 661 catchments in France
Authors: Devers Alexandre , Vidal Jean-Philippe , Lauvernet Claire , Vannier Olivier , Caillouet Laurie 
Published: July 2024

Abstract. The recent development of FYRE (French hYdroclimate REanalysis) Climate, a high-resolution ensemble daily reanalysis of precipitation and temperature covering the 1871–2012 period and the whole of France, offers the opportunity to derive streamflow series over the country from 1871 onwards. The FYRE Climate dataset has been used as input for hydrological modelling over a large sample of 661 near-natural French catchments using the GR6J (Génie Rural à 6 Paramètres Journaliers) lumped conceptual model. This approach led to the creation of the 25-member hydrological reconstructions, HydRE (Hydrological REconstruction), spanning the 1871–2012 period. Two sources of uncertainties have been taken into account: (1) the climate uncertainty using forcings from all 25 ensemble members provided by FYRE Climate and (2) the streamflow measurement error by perturbing observations used during the calibration. Further, the hydrological model error based on the relative discrepancies between observed and simulated streamflow has been added to derive the HydREM (Hydrological REconstruction with Model error) streamflow reconstructions. These two reconstructions are compared to other hydrological reconstructions with different meteorological inputs, hydrological reconstructions from a machine learning algorithm, and independent and dependent observations. Overall, the results show the added value of the HydRE and HydREM reconstructions in terms of quality, uncertainty estimation, and representation of extremes, therefore allowing us to better understand the variability in past hydrology over France.