bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarkers of inflammation and matrix remodeling in patients with acute coronary syndrome and vulnerable plaque
Authors: Kovalskaya A. N. , Duplyakov D. V. , Kuritsyna A. P. , Limareva L. V. 
Published: July 2024

Aim. To evaluate the relationship between markers of inflammation and matrix remodeling and criteria for a vulnerable plaque according to multislice computed tomography (MSCT) coronary angiography, as well as lipid profile parameters in patients with acute coronary syndrome (ACS).Material and methods. This prospective single-center study included 125 patients admitted urgently with ACS. All patients underwent percutaneous coronary intervention of the infarct-related artery. In ad­dition, in all patients, there were plaques in one or two non-infarct-related arteries with stenosis <50%. ACS was treated according to clinical guidelines, including statin therapy at the maximum dosage. After 1 month, all patients underwent MSCT coronary angiography to detect vulnerable plaques, as well as assessment of the lipid profile, and following biomarkers of inflammation and matrix remodeling: metalloproteinase-9 with its inhibitor type 1 (MMP-9 and TIMP-1), galectin-3 (Gal-3), neutrophil gelatinase-associated lipocalin (NGAL).Results. Of the 125 patients, myocardial infarction (MI) was diagnosed in 94 people (75%). Criteria for the plaque vulnerability according to MSCT were identified in 55 (44%) patients, of which positive remodeling was detected in 35 patients, a low-density area (LDA) in 30, and punctate calcifications (PCs) in 11. Gal-3 concentration was significantly higher without LDA — 35,4 (8,6; 65,0) ng/ml, in comparison with the group of patients in whom this criterion was detected and was 16,1 (5,9; 27,4) ng/ml (p=0,006). In the absence of PCs, the Gal-3 concentration was >34,0 (8,6; 61,0) vs 5,9 (2,8; 25,4) ng/ml in the group with PCs (p=0,046). The regression model including the MMP-9, TIMP-1, NGAL, Gal-3 in identifying vulnerable plaques was found to be significant (p<0,001).Conclusion. Criteria for vulnerable plaque in patients after ACS have a significant relationship with markers of inflammation and matrix remo­deling.
Relationship between microplastics and cardiovascular risk factors
Authors: Mamedov M. N. , Savchuk E. A. 
Published: July 2024

In recent years, plastic has been widely used in various anthropic activity fields, but its waste pollutes the environment. Under the influence of chemical processes, it decomposes micro- and nanoplas­tics, which enter the human body in various ways. New experimental studies indicate that they can cause a number of cardiovascular disorders, including endothelial cell dysfunction and induction of oxi­dative processes.The article examines the impact of environmental pollution with microplastics on the development of cardiovascular diseases. It is clear that new data on this new risk factor are accumulating and further clinical studies are required.
Российская Федерация – правовое демократическое государство
Authors: Goshulyak V. V. 
Published: July 2024

В статье рассматриваются конституционные характеристики Российского государства после конституционной реформы 2020 года. Автор выдвигает аргументы в обоснование позиции о том, что Российская Федерация продолжает оставаться правовым демократическим государством и после внесения поправок в Конституцию РФ. Сделан вывод о том, что поправки не изменили и не размыли основы конституционного строя. Российская Федерация может считаться эталоном для называющих себя демократическими стран объединенного Запада, отказавшихся от верховенства права, многополярного мира, свободного и демократического развития других стран, не входящих в его состав, сделавших ставку на диктат и силовое решение назревших проблем мирового развития, не считающихся с общепризнанными принципами и нормами международного права.
Mantle Wedge Heterogeneities and Afterslip Distribution Following the 2004 Mw 9.2 and 2005 Mw 8.6 Sumatra Earthquakes
Authors: Yang Siyuan , Hu Yan , Zhang Jian 
Published: July 2024

Abstract
Viscoelastic postseismic deformation following the 2004 Mw 9.2 Sumatra and 2005 Mw 8.6 Nias earthquakes extend thousands and hundreds of kilometers from the rupture area, respectively, providing an opportunity to better understand the rheology of the northern Sumatra subduction zone. We have developed a 3D viscoelastic finite-element model to study the postseismic deformation of the 2004 and 2005 events. The time-dependent and stress-driven afterslip is simulated by a 2-km-thick shear zone. Model results indicate that the viscosity of the shear zone of the two events is different, and their boundary is the southern edge of the 2004 rupture area, which is also consistent with the southern edge of the Andaman microplate. The viscosity of the shear zone is determined to be 2×1017  Pa·s in the northern segment, 1016  Pa·s at shallow depths (≤20 km) and 2×1018  Pa·s at greater depths (&gt;20 km) in the southern segment. Afterslip of the 2004 event takes place mostly surrounding the rupture area and is up to 3.2 m within 10 yr after the earthquake. Afterslip of the 2005 event takes place mostly up-dip of the rupture and is up to 4.3 m. The viscosity of the weakened areas in the Andaman spreading center and Toba volcano is determined to be 1018  Pa·s and 3×1018  Pa·s, respectively. A test model with the oceanic asthenosphere extending to depths up to 110 km better explains the vertical motion in the near field.
Designing a laboratory assistant attendance system using Radio Frequency Identification (RFID) technology based on IOT
Authors: Pratama Maulana Krisna Bayu , Dewi Yulia Puspita , Kusumawati Tri Ika Jaya , Pebrianti Dwi 
Published: July 2024

Abstrak: Tujuan penelitian ini untuk menghasilkan perangkat presensi RFID (Radio Frequency Identification) sebagai sistem presensi asisten lab di Lab Information and Communication of Technology (ICT) Terpadu Budi Luhur untuk mengatasi permasalahan yang sedang terjadi seperti antrean, kerumitan saat menginput, dan manipulasi waktu kehadiran sampai kepulangan. Pengembangan sistem ini menggunakan metode agile yang bisa menangani risiko ketidakberhasilan dalam tahap pengembangan sistem skala kecil maupun besar. Tahapan merancang sistem memanfaatkan Unified Modeling Language (UML). Pengumpulan data dilakukan dengan teknik observasi, wawancara, dan kuesioner terhadap lingkungan LAB ICT Terpadu Budi Luhur. Hasil penilaian ahli kelayakan pengujian mencapai persentase 90 (sangat pantas), pengujian praktis mencapai persentase 92 (sangat pantas), uji keamanan mencapai persentase 90 (layak), dan uji coba kelompok besar mencapai persentase 90 (sangat pantas). Dapat disimpulkan perancangan sistem dengan menggunakan UML dengan teknologi RFID dapat meningkatkan efektivitas presensi serta menyelesaikan permasalahan dalam presensi. Abstract: The current study attempted to generate an RFID (Radio Frequency Identification) attendance device as a bridge of attendance for the Computer Lab Assistant of Budi Luhur to overcome ongoing problems such as queues, complexity when inputting, and manipulation of attendance time to return. The development of this system uses agile methods that can handle the risk of failure in the small and large-scale system development stages. The system design stage uses UML. The data was collected using observation, interviews, and questionnaires in the Budi Luhur Integrated ICT LAB environment. The outcomes of the viability examination expert assessment attained a rate of 90 percent (highly achievable), the practicality test achieved a level of 92 (highly achievable), the security test attained a level of 90 (practicable), the large-group trial achieved a level of 90 (highly achievable). It can be concluded that designing a system using UML with RFID technology can increase the effectiveness of attendance and solve problems in it.
Amine moieties play different roles as electron-donating groups on quinoline derivatives
Authors: Borges Vancley S. , de Sousa Daniel S. , Melo Fernanda P. A. , Vale Joyce K. L. , Neto Antonio M. J. Chaves , de Sousa Alexsandro G. , Silva Albérico B. F. da , Borges Rosivaldo dos Santos 
Published: July 2024

Abstract

Quinoline derivatives play a crucial role in antimalarial therapy, and their biological properties are highly dependent of their basicity, particularly at the amine groups. The Amine moieties significantly contribute to the antioxidant capacity of quinoline derivatives through electron transfer mechanisms. A theoretical study was conducted to investigate the structure-nucleophilicity and antioxidant capacity of quinoline derivatives, specifically chloroquine and quinine, through electron transfer using DFT/B3LYP/6-311++G(2d,2p) methods. The HOMO values were utilized to assess nucleophilicity, while the ionization potential was indicative of electron donating capacity. To explore different aspects of the molecules, three approaches were proposed: simplification, fragmentation, and modification on amine moieties. Our findings reveal a synergistic effect between 4-amino-quinoline and tertiary amine in quinoline derivatives, enhancing their overall antioxidant capacity. However, the presence of the chlorine atom decreases its contribution as an electron withdrawing group. Chloroquine exhibits a higher antioxidant capacity when compared to quinine, and their respective electron donation abilities are correlated with their pKa values. The synergistic effect between the 4-amino-quinoline and tertiary amine is particularly evident in chloroquine, surpassing the antioxidant capacity of 6-methoxy-4-methyl-quinoline moiety in quinine.
Trends and forecasts of extreme rainfall in small, medium and large towns in Burkina Faso: a non-parametric statistical analysis and Holt-Winters Smoothing Method (West Africa)
Authors: Joseph YAMEOGO 
Published: July 2024

Abstract

Climate extremes have become an important issue in recent years, leading to renewed scientific interest in the topic. However, few studies have focused on the analysis of precipitation extremes in large, medium, and small towns in Burkina Faso, a Sahelian country in West Africa. This study aims to analyse trends and future projections of rainfall extremes in small, medium, and large cities in Burkina Faso. To this end, rainfall data were collected from the National Meteorological Agency of Burkina Faso (NMABF) over the period 1991-2020 at monthly time steps. The stations selected were Boromo for the small town of Boromo, Saria for the medium-sized town of Koudougou, and Bobo-Dioulasso for the city of Bobo-Dioulasso. The precipitation data were then entered into the Rclimdex software to produce precipitation indices. The extreme rainfall indices were analysed using descriptive statistics, linear regression, innovative graphical trends, and futures projections. The study shows that there is strong variability and an increasing monotonic trend in the extreme precipitation indices over the period 1990-2020. However, in the city of Koudougou, the trends are nonmonotonically increasing. The study also shows that the forecast based on the Holt-Winter additive model shows that extreme precipitation indices will increase in the study cities. However, the duration indices will decrease more in the city of Koudougou.
The body postures of individuals of both sexes ranging in height from 180 to 195 cm, in the light of the mora phenomenon
Authors: Mrozowiak Mirosław , Stępień-Słodkowska Marta , Sokołowski Marek 
Published: July 2024

Abstract

Background
Proper muscle tension is an essential element for correct body posture and motion. It should be high enough to counteract gravity and low enough to provide smooth, selective movement and isolated activity. Improper muscle tension will disturb the correct development of the body schema. The quality of muscle tension will be dependent upon the following: genetic factors, localization and the degree of damage to the central nervous system. The aim of the study was an attempt to determine the value of features describing the body posture of women and men with a body height of 180 cm to 195 cm.
Methods
The research was conducted in a group of 123 people with the body height ranging from 180 to 195 cm, coming from the entire territory of Poland. The photogrammetric method has been implemented in registering 41 features which are descriptive of body posture.
Results
The research results demonstrated that the average thoracic kypnosis angle and the lumbar lordosis as well as the Alpha, Beta and Gamma angles included in the sagittal planes are located between the upper and the lower values of normative ranges for both 18 year old males and females. The size of the asymmetry of the axial locomotor system in coronal and sagittal planes and the pelvis, the height and the width of waist triangles, asymmetry of shoulder blades and shoulders in coronal and transverse planes was included between the upper and the lower extremum of normative range.
Conclusions
The research material is a representative group for the analyzed body height and sex, because it was strictly selected in terms of somatic structure, body posture, physical activity and lifestyle. The sizes of the features describing the body posture of women and men with a body height of 180 cm to 195 cm fall within the ranges of the normative posture features adopted for 18-year-olds diagnosed with the use of the mora projection method.
Study on the Influence of Nonlinear Change of Regional GNSS Station Coordinate Time Series and Environmental Loading
Authors: Zhang Zihao , Xu Keke , Liu Yifu , Wan Tongtong , Zhu Yongzhen , Wang Xiang 
Published: July 2024

Abstract

Aiming at the difficulties in extracting the constructive and non-constructive information of GNSS coordinate time series effectively and identifying and removing noise effectively, this paper pro-poses an improved model combining improved complete ensemble EMD (ICEEMDAN) and long short-term memory (LSTM). Firstly, the GNSS time series was decomposed by ICEEMDAN, and then the decomposed components were divided into high frequency, low frequency and trend items by using Hausdorff Distance (HD). Finally, the signal was reconstructed by LSTM. The results of simulation experiment and real data experiment (Yunnan region) show that the model can effectively extract the nonlinear part of coordinate time series. Compared with continuous root mean square error (CMSE), energy density (ET) and correlation coefficient rule, HD can effectively identify and eliminate the noisy part of the signal. In addition, compared with the linear motion model, this model can effectively extract the nonlinear trend part of the signal. After the correction of period terms, the average RMS of the model in the E, N and U directions decreased by 46.57%, 35.09%, 44.48% and 15.11%, 4.10% and 3.42%, respectively, compared with that of the harmonic model and the ensemble EMD (EEMD), indicating that the model can extract the period information more fully. In addition, this paper also proposes to combine the model with the environmental load to weaken the nonlinear changes in the signal. The results show that: The mean RMS decreases by 14.32%, 9.46% and 4.05%, respectively, when hydrographic load, non-tidal atmospheric load and Marine load are added in the U direction. There is no significant change in the horizontal RMS, indicating that the elevation direction of the station in Yunnan region is susceptible to environmental load. It is also found that the smaller the phase difference between the load series and the load series after load correction, the closer the annual cycle amplitude, the better the effect of load correction.
Theoretical Investigation of Interactions between HIV-1 Tat and p53 proteins
Authors: Koseoglu Sinem , Yenici Cansu M. , Celikbas Sena , Aygun Serra , Altun Y. Dicle , Baday Sefer , Alpturk Onur 
Published: July 2024

Abstract

HIV-1 Tat (transactivator of transcription) protein is the main arsenal of HIV, playing numerous roles during viral infection. This protein is inherently disordered, lacking any secondary structures. This plasticity allows HIV-1 Tat to engage in interaction with multiple proteins and biological molecules, resulting in either collapse of the immune system or severe damage to tissues. Proteomic studies previously revealed p53, commonly cited as the guardian angel of the genome to interact with the Tat protein through its tetramerization domain. As p53 is crucial in terms of whether the cell dies or lives, its interaction with the Tat protein is of broad interest in the pathogenesis of HIV infection. For this reason, we investigated the complexation between the Tat protein and the tetramerization domain of p53 using molecular docking and molecular dynamics simulations. Our results indicate that the N-terminal and C-terminal of Tat exhibit different behaviors in their interactions with p53. The N-terminal domain of Tat favours complexation with p53 thermodynamically, while its C-terminal exerts the opposite effect. These results align very much with the previously reported experimental observations. We believe the results reported in this manuscript are significant for developing novel therapeutic agents targeting the p53/Tat interaction.
Temporal transcriptional profiling of host cells infected by a veterinary alphaherpesvirus using Nanopore sequencing
Authors: Tombácz Dóra , Maróti Zoltán , Oláh Péter , Dörmő Ákos , Gulyás Gábor , Kalmár Tibor , Csabai Zsolt , Boldogkői Zsolt 
Published: July 2024

Abstract

In our research, we performed temporal transcriptomic profiling of host cells infected with Equid alphaherpesvirus 1 by utilizing direct cDNA sequencing based on nanopore MinION technology. The sequencing reads were harnessed for transcript quantification at various time points. Viral infection-induced differential gene expression was identified through the edgeR package. The identified genes were segmented into six groups based on their kinetic characteristics. The initial three clusters encompass immediate-early response genes, typically transcription factors and elements of antiviral signaling pathways. These genes were either upregulated (cluster 1) or downregulated (clusters 2 and 3) during the early infection phase. The remaining three clusters include late response genes. In these categories, it is challenging to determine whether changes in gene expression are functionally linked to the viral infection or merely side effects of the infection. A study of gene associations using the STRINGDB software revealed several gene networks that might be directly impacted by the virus. Lastly, we explored whether gene co-expression could be a result of their collective regulation by upstream transcription factors using the Gene Regulatory Network database.
Perceived Parental Responsiveness and Neuroticism as Predictors of Bullying Behaviour Among In-School Adolescents in Ibadan, OYO State
Authors: Aruoture Ezekiel O , Adegoke Mariam A 
Published: July 2024

Abstract

Bullying has been seen as a public health issue given to the fact that it causes psychosocial and academic problems in thousands of children worldwide. This study investigated how perceived parental responsiveness and neuroticism predict bullying behaviour among in-school adolescents in Ibadan, Oyo state. A Cross-sectional research design, involving a purposively sampled 428 participants from both private and public secondary schools whose mean age of 15.06 ± 1.52 years was utilized. A 37-item self-report questionnaire comprising socio-demographics, perceived parental responsiveness (α = .93), neuroticism (α = .62), and bullying behaviour (α = .86) was administered. Four hypotheses were tested using multiple regression, t-test of independence and One-way ANOVA, at 0.05 level of significance. Results showed that Perceived parental responsiveness and neuroticism jointly predicted bullying behaviour [F(2,363) = 56.40, R = .49, R2 = .24, p < .001]. Independently, perceived parental responsiveness (β = − .46; t = -8.89; P < .001) and neuroticism (β = .14; t = 2.92; P < .05) significantly predicted bullying behaviour. Results further revealed that male adolescents (= 13.12) reported significantly higher bullying behaviour than female adolescents (= 10.31). Furthermore, the result revealed a significant difference in the mean score of parental marital status on bullying behaviours [F (4, 422) = 4.41; P < .01]. It was discovered that adolescents whose parents are divorced (x̅ = 19.73) reported higher bullying behaviour. More so, the result shows that bullying is higher in private schools than in public schools. Conclusively, bullying behaviour differs by gender, type of school, level of parental responsiveness, neuroticism and marital status of their parent.
Asthma prescribing trends, inhaler adherence and outcomes: a Real-World Data analysis of a multi-ethnic Asian Asthma population
Authors: Toh Ming Ren , Ng Gerald Xuan Zhong , Goel Ishita , Lam Shao Wei , Wu Jun Tian , Lee Chun Fan , Ong Marcus Eng Hock , Matchar David Bruce , Tan Ngiap Chuan , Loo Chian Min , Koh Mariko Siyue 
Published: July 2024

Abstract

Background
Inhaled corticosteroid (ICS) is the mainstay therapy for asthma, but general adherence is low. There is a paucity of real-world inhaler prescribing and adherence data from Asia and at the population level. To address these gaps, we performed a real-world data analysis of inhaler prescribing pattern and adherence in a multi-ethnic Asian asthma cohort and evaluated the association with asthma outcomes.
Methods
We performed a retrospective analysis of adult asthma patients treated in the primary and specialist care settings between 2015 to 2019. Medication adherence was measured using the medication possession ratio (MPR), and categorised into good adherence (MPR 0.75–1.2), poor adherence (MPR < 0.75) or medication oversupply (MPR > 1.2). All statistical analyses were performed using R Studio.
Results
8,023 patients, mean age 57 years, were evaluated between 2015–2019. Most patients were receiving primary care (70.4%) and on GINA step 1–3 therapies (78.2%). ICS-long-acting beta-2 agonist (ICS-LABA) users increased over the years especially in the primary care, from 33–52%. Correspondingly, inpatient admission and ED visit rates decreased over the years. Short-acting beta-2 agonist overdispensing (3 or more canisters per year) remained high (40.7–46.7%). Between 2015 and 2019, the proportion of patients with poor adherence decreased from 12.8–10.5% (for ICS) and from 30.0–26.8% (for ICS-LABA) respectively. Factors associated with poor adherence included minority ethnic groups (OR 0.73–0.93; compared to Chinese), presence of COPD (OR 0.75, 95% CI 0.59–0.96) and GINA step 4 treatment ladder (OR 0.71, 95% CI 0.61–0.85). Factors associated with good adherence were male gender (OR 1.14, 95% CI 1.01–1.28), single site of care (OR 1.22 for primary care and OR 1.76 for specialist care), GINA step 2 treatment ladder (OR 1.28, 95% CI 1.08–1.50). Good adherence was also associated with less frequent inpatient admission (OR 0.91, 95% CI 0.84–0.98), greater SABA overdispensing (OR 1.66, 95% CI 1.47–1.87) and oral corticosteroids use (OR 1.10, 95% CI 1.05–1.14).
Conclusions
Inhaled corticosteroid (ICS) adherence has improved generally, however, poor adherence was observed for patients receiving asthma care in both primary and specialist care, and those from the minority ethnicities.