bluuebunny/crossref_metadata_2025_split huggingface dataset:
The oblique plane deformity in slipped capital femoral epiphysis
Authors: Cooper Anthony Philip , Salih Saif , Geddis Carolyn , Foster Patrick , Fernandes James A. , Madan Sanjeev S. 
Published: February 2014

Background Slipped capital femoral epiphysis (SCFE) is commonly treated with in situ pinning. However, a severe slip may not be suitable for in situ pinning because the required screw trajectory is such that it risks perforating the posterior cortex and damaging the remaining blood supply to the capital epiphysis. In such cases, an anteriorly placed screw may also cause impingement. It is also possible to underestimate the severity of the slip using conventional radiographs. The aim of this study was to describe and evaluate a novel method for calculating the true deformity in SCFE and to assess the interobserver and intraobserver reliability of this technique. Methods We selected 20 patients with varying severity of SCFE who presented to our institution. Cross-sectional imaging [either axial computed tomography (CT) scans or magnetic resonance imaging (MRI) scans] and anteroposterior (AP) pelvis radiographs were assessed by four reviewers with varying levels of experience on two occasions. The degree of slip on the axial image and on the AP pelvis radiographs were measured and, from this, the oblique plane deformity was calculated using the method as popularised by Paley. The intraclass correlation coefficient (ICC) was calculated to determine the interobserver and intraobserver reliabilities between and amongst the raters. Results The interobserver reliability for the calculated oblique plane deformity in SCFE ICC was 0.947 [95 % confidence interval (CI) 0.90–0.98] and the intraobserver reliability for the calculated oblique plane deformity of individual raters ranged from 0.81 to 0.94. The deformity in the oblique plane was always greater than the deformity measured in the axial or the coronal plane alone. Conclusion This method for calculating the true deformity in SCFE has excellent interobserver and intraobserver reliability and can be used to guide treatment options. This technique is a reliable and reproducible method for assessing the degree of deformity in SCFE. It may help orthopaedic surgeons with varying degrees of experience to identify which hips are suitable for in situ pinning and those which require surgical dislocation and anatomical reduction, given that plain radiographs in a single plane will underestimate the true deformity in the oblique plane. Level of evidence Level II diagnostic study.
Exothermic properties of plaster–synthetic composite casts
Authors: Burghardt Rolf D. , Anderson John G. , Reed Rob A. , Herzenberg John E. 
Published: February 2014

Purpose Plaster casts can cause burns. Synthetic casts do not. Composite plaster–synthetic casts have not been thoroughly evaluated. This study analyzed the temperature from plaster casts compared with composite casts in a variety of in vitro conditions that would simulate clinical practice. Methods A Pyrex cylinder filled with constant body temperature circulating water simulated a human extremity. Circumferential casts, of either plaster or composite construction (plaster inner layer with outer synthetic layer), were applied to the model. Peak temperatures generated by the exothermic reactions were studied relative to the following variables: dip water temperature (24 °C versus 40 °C), cast thickness (16, 30, and 34 ply), and delayed (5-min) versus immediate application of the synthetic outer layers. Peak temperatures from the all-plaster casts were compared with the composite casts of the same thickness. Finally, the relative cast strength was determined. Results Potentially dangerous high temperatures were measured only when 40 °C dip water was used or when thick (30- or 34-ply) casts were made. Cast strength increased with increasing cast thickness. However, the presence of synthetics in the composite casts layers did not increase cast strength in every case. Conclusion When applying composite casts, the outer synthetic layers should be applied several minutes after the plaster to minimize temperature rise. Composite casts do not routinely generate peak temperatures higher than plaster casts of similar thickness. Because the skin of children and the elderly is more temperature-sensitive than average adult skin, extra care should be taken to limit the exothermic reaction when casting children and the elderly: clean, room temperature dip water, minimal required cast thickness, avoidance of insulating pillows/blankets while the cast is drying.
Does Sludge/Debris Exist in Today's Vascular Access Ports?
Authors: Dalton Michael , Pheil Natan , Lacy Jim , Dalton Jordan 
Published: February 2014

AbstractSludge is defined as a slushy mass, deposit, or sediment. In vascular access ports (VAPs), it appears to be the buildup of clotted blood, blood components, drug and mineral precipitates or residues, and lipids that adhere to or reside in the internal path of the reservoir. Several studies note the presence of sludge as a risk factor for increased incidence of VAP-related bloodstream infections as well as higher occlusion rates. Overall, the occurrence of sludge in implanted vascular ports may increase patient-associated risks and costs to health care providers by as much as $40,000 per incident. Understanding the significance of these associated risks and costs may lead to solutions that save health care facilities money; better serve health care providers; and ultimately, improve patient outcomes.
Enhancing Nursing Students' Experience in the Assessment and Care of Vascular Access Devices
Authors: Freeland Barbara S. , Dempsey David J. 
Published: February 2014

Abstract
Background: Bachelor of Science in Nursing students get minimal exposure or experience in the assessment and care of vascular access devices (VADs) let alone the placement of such devices. Students in our university nursing program receive no structured experience. Students learn how to assess and care for VADs in the clinical setting while working with clinical faculty and staff nurse mentors.
Purpose: The purpose of this pilot program was to increase the awareness and understanding of VADs for third-year nursing students to enhance their comfort level in assessing and caring for these devices.
Methods: Thirty-two third-year nursing students, in groups of 8, participated in this pilot program in addition to their usual academic and clinical assignments. The 4 structured components of this program included a didactic session to share basic VAD information, simulation laboratory time to practice peripheral intravenous line insertion, a 4-hour one-to-one shadowing experience with a vascular access service team registered nurse providing patient care, and a wrap-up session by the vascular access service team educational nurse coordinator to provide debriefing and additional information.
Conclusions: Students who participated in this pilot program expressed an increased level of comfort regarding VADs. They came away with knowledge that other nursing students in the program do not receive during their academic and clinical time.
Plant-mediated whitefly–begomovirus interactions: research progress and future prospects
Authors: Luan Jun-Bo , Wang Xiao-Wei , Colvin John , Liu Shu-Sheng 
Published: February 2014

AbstractPlant-mediated interactions between begomoviruses and whiteflies exert important influences on the population dynamics of vectors and the epidemiology of plant diseases. In this article, we synthesize the relevant literature to identify patterns to the interactions. We then review studies on the ecological, biochemical and molecular mechanisms underlying the interactions and finally elaborate on the most interesting issues for future research. The interactions between begomoviruses and the insect vector, the whitefly Bemisia tabaci, via their shared host plants can be mutualistic, neutral or negative. However, in contrast to a pattern of improved performance of vectors on virus-infected plants that has been observed with persistently transmitted RNA viruses, the number of cases exhibiting mutualistic, neutral or negative effects in the indirect interactions between begomoviruses and whiteflies appear evenly distributed. With regard to the mechanisms of plant-mediated positive effects on whiteflies, two case studies indicate that suppression of plant defence and/or alteration in plant nutrition as a result of virus infection can be important. Our review shows that we are only just beginning to understand the tripartite interactions between begomoviruses, whiteflies and plants. Future efforts in this area should try to expand the number and diversity of pathosystems for investigation to reveal the patterns of interactions, to investigate the molecular and biochemical mechanisms of the interactions using a multidisciplinary approach, and to examine the virus–plant–vector interactions in the field and in natural plant communities.
Patterns of cervical lymph node metastases in oral tongue squamous cell carcinoma: implications for elective and therapeutic neck dissection
Authors: Dogan E , Cetinayak H O , Sarioglu S , Erdag T K , Ikiz A O 
Published: February 2014

AbstractObjectives:To determine the patterns of lymph node metastases in oral tongue carcinomas, and examine the implications for elective and therapeutic neck dissection.Method:The study entailed a retrospective analysis of 67 patients with previously untreated oral tongue squamous cell carcinoma who had undergone simultaneous glossectomy and neck dissection.Results:Of the 40 clinically node-negative patients, 7 patients had metastatic lymph nodes on pathological examination. No occult metastasis was found at level IV. Of the 27 clinically node-positive patients, the incidence rate of level IV metastasis was 11.1 per cent (3 out of 27 patients). No ‘skip metastases’ were found at level IV. Level IV metastases were significantly related to clinically staged nodes categorised as over 2a (p = 0.03) and metastasis to level III (p = 0.01).Conclusion:Routine inclusion of level IV in elective neck dissection is not necessary for clinically node-negative patients with oral tongue squamous cell carcinoma. Furthermore, extended supraomohyoid neck dissection with adjuvant radiotherapy can be sufficient in the treatment of selected patients with clinically node-positive necks.
Lipids of adult brown shrimp,Crangon crangon: seasonal variations in fatty acids class composition
Authors: Mika Adriana , Gołębiowski Marek , Skorkowski Edward , Stepnowski Piotr 
Published: February 2014

Sea food is very rich in lipids. The brown shrimp,Crangon crangonis a most popular and very valuable taxon in the White Sea, in the Mediterranean and in the Black Seas. The aim of this study was to determine the seasonal variations of lipids inC. crangonmuscle tissue using gas chromatography–mass spectrometry. The lipids were separated into groups: neutral lipids (triacylglycerols, free fatty acids, sterols) and polar lipids (phospholipids), by high performance liquid chromatography with a laser light-scattering detector. Fatty acids were identified using the GC-MS technique. The mainly fatty acids were 16:0, 18:0 (saturated FAs), 16:1, 18:1 (monounsaturated FAs), 20:4 (ARA), 20:5 (EPA) and 22:6 (DHA). The largest amounts of fatty acids in the muscle were observed in spring; these were the result of collecting food after winter and before reproduction. The muscle lipid content was 32.2 ± 1.8 mg g−1. The summer was the poorest season and the lipid value was 7.7 ±0.4 mg g−1. The levels of muscle neutral lipids (NL) oscillated between 80% (autumn) and 90% (spring). The temperature and salinity has a significant influence on content and profile of fatty acids. This work will help to understand the biology, the seasonal variation in lipid mass, lipid classes content and fatty acids profile in the abdominal muscle ofC. crangon.
Salieri’sFalstaff, ossia Le tre burleandThe Merry Wives of Windsor: Operatic Adaptation and/as Shakespeare Criticism
Authors: Severn John R. 
Published: February 2014

AbstractShakespeare’sThe Merry Wives of Windsorcontains several features that make it unusual within his dramatic output and that thus render problematic the idea of a unified ‘Shakespearean’ canon. Until very recently, literary criticism has either largely ignored or denigrated the play, with a sustained interest in its portrayal of female agency, family life and the natural world only consolidating in the early twenty-first century. However, earlier operatic adaptations, such as Salieri and Defranceschi’sFalstaff, ossia Le tre burle, demonstrate an engagement with those issues which literary criticism has only lately addressed. While approaches to adaptations ofThe Merry Wivesoften focus primarily on the character of Falstaff, Salieri and Defranceschi’s opera’s engagement with the play’s issues beyond Falstaff suggests it might give added weight to a growing awareness of a positive alternative reception history of the play beyond literary criticism. At the same time, a consideration of the opera’s engagement with the play’s themes of female agency, family life and the natural world might shed light onFalstaff, ossia Le tre burlebeyond the shadow cast by Verdi’s central character.
Prospects for Vibrational-Mode EELS with High Spatial Resolution
Authors: Egerton R.F. 
Published: February 2014

AbstractTaking advantage of previous measurements by Geiger and co-workers, we discuss the possibilities and problems of measuring vibrational modes of energy loss in a transmission electron microscope fitted with a monochromator and a high-resolution energy-loss spectrometer. The tail of the zero-loss peak is seen to be a major limitation, rather than its full-width at half-maximum. Because of the low oscillator strengths and small cross-sections involved, radiation damage will limit the spatial resolution if this technique is applied to organic specimens. Delocalization of the inelastic scattering may also be a limitation, if a dipole description of the scattering process is valid.
Characterization of Fibrous Mimetite
Authors: Thiéry Vincent 
Published: February 2014

AbstractMimetite, Pb5(AsO4)3Cl, is a ubiquitous mineral that is of interest in various fields such as ore mineralogy, environmental studies, and minerals engineering. Mimetite generally forms hexagonal prisms and barrel-shaped crystals, but its fibrous form is quite an uncommon one. Here we attempt to present its worldwide occurrences on the basis of a literature review. We then present a study on fibrous mimetite from one of its historical locations based on the petrographic microscope, SEM-SE and EDX, and Raman spectroscopy.
Performance of High-Resolution SEM/EDX Systems Equipped with Transmission Mode (TSEM) for Imaging and Measurement of Size and Size Distribution of Spherical Nanoparticles
Authors: Hodoroaba Vasile-Dan , Motzkus Charles , Macé Tatiana , Vaslin-Reimann Sophie 
Published: February 2014

AbstractThe analytical performance of high-resolution scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDX) for accurate determination of the size, size distribution, qualitative elemental analysis of nanoparticles (NPs) was systematically investigated. It is demonstrated how powerful high-resolution SEM is by using both mono- and bi-modal distributions of SiO2 airborne NPs collected on appropriate substrates after their generation from colloidal suspension. The transmission mode of the SEM (TSEM) is systematically employed for NPs prepared on thin film substrates such as transmission electron microscopy grids. Measurements in the transmission mode were performed by using a “single-unit” TSEM transmission setup as manufactured and patented by Zeiss. This alternative to the “conventional” STEM detector consists of a special sample holder that is used in conjunction with the in-place Everhart–Thornley detector. In addition, the EDX capabilities for imaging NPs, highlighting the promising potential with respect to exploitation of the sensitivity of the new large area silicon drift detector energy dispersive X-ray spectrometers were also investigated. The work was carried out in the frame of a large prenormative VAMAS (Versailles Project on Advanced Materials and Standards) project, dedicated to finding appropriate methods and procedures for traceable characterization of NP size and size distribution.
Sectioning of Individual Hematite Pseudocubes with Focused Ion Beam Enables Quantitative Structural Characterization at Nanometer Length Scales
Authors: Asenath-Smith Emily , Estroff Lara A. 
Published: February 2014

AbstractA dual-beam focused ion beam microscope equipped with a nanomanipulator was used to fabricate slices from within individual hematite (α-Fe2O3) pseudocubes with selected orientations with respect to the original pseudocubes. Transmission electron microanalysis through selected area electron diffraction enabled assignment of each thin section to a particular zone of the hematite lattice. While the pseudocubes are composed of numerous crystallites, 25–50 nm in size, they are not simply polycrystalline particles. Electron diffraction of thin sections showed that while the pseudocubic hematite particles are composed of numerous coherent domains, the individual thin sections display a net crystallographic orientation to the underlying hematite lattice. Quantitative analysis of the lattice misorientation between coherent domains was calculated from the azimuthal spread of electron diffraction peaks and is consistent with a structure that contains small-angle grain boundaries. Based upon this analysis, we conclude that the pseudocubic hematite particles are mosaic crystals, composed of highly oriented coherent domains.
Ultrahigh spin thermopower and pure spin current in a single-molecule magnet
Authors: Luo Bo , Liu Juan , Lü Jing-Tao , Gao Jin-Hua , Yao Kai-Lun 
Published: February 2014

AbstractUsing the non-equilibrium Green's function (NEGF) formalism within the sequential regime, we studied ultrahigh spin thermopower and pure spin current in single-molecule magnet(SMM), which is attached to nonmagnetic metal wires with spin bias and angle (θ) between the easy axis of SMM and the spin orientation in the electrodes. A pure spin current can be generated by tuning the gate voltage and temperature difference with finite spin bias and the arbitrary angle except of "Equation missing". In the linear regime, large thermopower can be obtained by modifying Vg and the angles (θ). These results are useful in fabricating and advantaging SMM devices based on spin caloritronics.
Experimental demonstration of a transparent graphene millimetre wave absorber with 28% fractional bandwidth at 140 GHz
Authors: Wu Bian , Tuncer Hatice M. , Naeem Majid , Yang Bin , Cole Matthew T. , Milne William I. , Hao Yang 
Published: February 2014

AbstractThe development of transparent radio-frequency electronics has been limited, until recently, by the lack of suitable materials. Naturally thin and transparent graphene may lead to disruptive innovations in such applications. Here, we realize optically transparent broadband absorbers operating in the millimetre wave regime achieved by stacking graphene bearing quartz substrates on a ground plate. Broadband absorption is a result of mutually coupled Fabry-Perot resonators represented by each graphene-quartz substrate. An analytical model has been developed to predict the absorption performance and the angular dependence of the absorber. Using a repeated transfer-and-etch process, multilayer graphene was processed to control its surface resistivity. Millimetre wave reflectometer measurements of the stacked graphene-quartz absorbers demonstrated excellent broadband absorption of 90% with a 28% fractional bandwidth from 125–165 GHz. Our data suggests that the absorbers' operation can also be extended to microwave and low-terahertz bands with negligible loss in performance.
Structural and mechanistic insights into an extracytoplasmic copper trafficking pathway in Streptomyces lividans
Authors: Blundell Katie L. I. M. , Hough Michael A. , Vijgenboom Erik , Worrall Jonathan A. R. 
Published: February 2014

In Streptomyces lividans an extracytoplasmic copper-binding Sco protein plays a role in two unlinked processes: (i) initiating a morphological development switch and (ii) facilitating the co-factoring of the CuA domain of CcO (cytochrome c oxidase). How Sco obtains copper once secreted to the extracytoplasmic environment is unknown. In the present paper we report on a protein possessing an HX6MX21HXM motif that binds a single cuprous ion with subfemtomolar affinity. High-resolution X-ray structures of this extracytoplasmic copper chaperone-like protein (ECuC) in the apo- and Cu(I)-bound states reveal that the latter possesses a surface-accessible cuprous-ion-binding site located in a dish-shaped region of β-sheet structure. A cuprous ion is transferred under a favourable thermodynamic gradient from ECuC to Sco with no back transfer occurring. The ionization properties of the cysteine residues in the Cys86xxxCys90 copper-binding motif of Sco, together with their positional locations identified from an X-ray structure of Sco, suggests a role for Cys86 in initiating an inter-complex ligand-exchange reaction with Cu(I)–ECuC. Generation of the genetic knockouts, Δsco, Δecuc and Δsco/ecuc, and subsequent in vivo assays lend support to the existence of a branched extracytoplasmic copper-trafficking pathway in S. lividans. One branch requires both Sco and to a certain extent ECuC to cofactor the CuA domain, whereas the other uses only Sco to deliver copper to a cuproenzyme to initiate morphological development.
Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase
Authors: Yu Tai-Yuan , Kao Yu-wen , Lin Jing-Jer 
Published: February 2014

Significance
Telomerase expression is essential for the long-term proliferation of most cancer cells. In cancer cells lacking telomerase, an alternative lengthening of telomeres (ALT) pathway is activated to maintain telomere length through telomere recombination. Using yeast as a model system, we found that the noncoding telomeric repeat-containing RNA (TERRA) plays a major role in recombination-mediated maintenance of telomere in telomerase-deficient cells. Increased levels of telomere-associated TERRA result in the accumulation of telomeric DNA–RNA hybrids and induce telomere recombination. Because the structure and function of TERRA are conserved among eukaryotes, our findings suggest that the accumulation of telomere-associated TERRA might also have a role in modulating the occurrence of ALT in cancer cells.
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
Authors: Loenarz Christoph , Sekirnik Rok , Thalhammer Armin , Ge Wei , Spivakovsky Ekaterina , Mackeen Mukram M. , McDonough Michael A. , Cockman Matthew E. , Kessler Benedikt M. , Ratcliffe Peter J. , Wolf Alexander , Schofield Christopher J. 
Published: February 2014

Significance
The processing of DNA sequences into proteins is fine-tuned to meet the conflicting demands of accuracy and speed. DNA mutations can introduce premature stop codons, leading to inactive proteins. We report that oxygen-dependent posttranslational modification of the ribosomal decoding center affects stop codon readthrough in an mRNA sequence-dependent manner. Our work demonstrates that oxygenases catalyzing RPS23 hydroxylation are conserved in eukaryotes, including yeasts, flies, and humans. In basal eukaryotes, RPS23 undergoes two hydroxylations, whereas in animals we only observe one hydroxylation. Yeast ribosomes lacking hydroxylation manifest altered stop codon readthrough up to ∼10-fold. The results reveal oxygen-dependent modifications that regulate translational accuracy and suggest unprecedented approaches to modulating ribosomal accuracy for medicinal application.