bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphology Control and Stabilization in Immiscible Polypropylene and Polyamide 6 Blends with Organoclay
Authors: Huang J. , Zhu Y. , Jiang W. , Cardinaels R. , Moldenaers P. , Shi D. 
Published: August 2014

Abstract
In the current study, 70/30 (w/w) polypropylene (PP)/polyamide 6 (PA6)/organoclay ternary blends were prepared by melt mixing in three different blending sequences, i. e., organoclay premixed with PA6 and then mixed with PP (S1 blending sequence), organoclay premixed with PP and then mixed with PA6 (S2 blending sequence), and organoclay, PA6 and PP mixed simultaneously (S3 blending sequence). The effects of organoclay on the phase morphologies, rheological properties and mechanical properties of the blends are examined to reveal the role of organoclay in these immiscible blends. First of all, the dispersion and distribution of organoclay is investigated using XRD and TEM techniques. The organoclay is exfoliated and distributed in the dispersed PA6 phase as well as at the interface between PA6 and PP. Interestingly, more organoclay sheets are observed at the interface when the S2 or S3 blending sequences are utilized. From the SEM images, it is clear that the domain size of the PA6 phase decreases remarkably after introducing organoclay into the PP/PA6 blends. Two different rheological protocols are applied to probe the effect of organoclay on the morphology of the blend by in-situ monitoring the morphological evolution. The rheological results reveal that the phase morphology of the PP/PA6 blends remains relatively stable during shear for a wide range of shear rates when 1.0 wt% organoclay has been added. For the blends with a relatively high clay loading (5.0 wt%), a characteristic and pronounced “plateau” is observed in the low frequency range of the G′-ω curves, which indicates the presence of a percolating network of clay nanosheets. From the mechanical measurements, we find that the tensile strength of the blends increases slightly first and then declines dramatically with increasing organoclay content. Moreover, the elongation at break drops sharply as the organoclay content increases. In summary, it is clear that the organoclay can effectively reduce the domain size of the dispersed PA6 phase and stabilize the phase morphology in shear flow. However, the mechanical properties of the blends are not really improved by clay addition, even though a cocontinuous morphology with a percolated clay network was generated.
Environmental and nursing-staff factors contributing to aggressive and violent behaviour of patients in mental health facilities
Authors: Van Wijk Evalina , Traut Annalene , Julie Hester 
Published: August 2014

Background: Aggressive and violent behaviour of inpatients in mental health facilities disrupts the therapeutic alliance and hampers treatment.Objectives: The aim of the study was to describe patients’ perceptions of the possible environmental and staff factors that might contribute to their aggressive and violent behaviour after admission to a mental health facility; and to propose strategies to prevent and manage such behaviour.Research design: A qualitative, phenomenological study was utilised, in which purposefully sampled inpatients were interviewed over a six-month period. Inpatients were invited to participate if they had been admitted for at least seven days and were in touch with reality.Method: Forty inpatients in two mental health facilities in Cape Town participated in face-to-face, semi-structured interviews over a period of six months. Tesch’s descriptive method of open coding formed the framework for the data analysis and presentation of the results. Trustworthiness was ensured in accordance with the principles of credibility, confirmability, transferability and dependability.Results: Analysis of the data indicates two central categories in the factors contributing to patients’ aggressive and violent behaviour, namely, environmental factors and the attitude and behaviour of staff. Conclusion: From the perspective of the inpatients included in this study, aggressive and violent episodes are common and require intervention. Specific strategies for preventing such behaviour are proposed and it is recommended that these strategies be incorporated into the in-service training programmes of the staff of mental health facilities. These strategies could prevent, or reduce, aggressive and violent behaviour in in-patient facilities.
Outcomes of surgical site infections in orthopedic trauma surgeries in a tertiary care centre in India
Authors: Rajkumari N , Gupta AK , Mathur P , Trikha V , Sharma V , Farooque K , Misra MC 
Published: August 2014

Background:
Surgical site infections (SSIs) still cause significant morbidity and mortality despite advances in trauma care. We have studied in this paper the rate of SSIs, their outcomes in patients undergoing interventions for trauma and SSI trends in developing countries.

Materials and Methods:
A 16-month study (May, 2011- August, 2012) was carried out. Patients undergoing interventions for orthopedic trauma were followed and assessed for SSIs and their outcomes and antimicrobial sensitivity patterns of the micro-organisms isolated were noted and correlated.

Results:
A total of 40 (4.4%) confirmed cases of SSIs were identified among 852 patients of orthopedic trauma. Based on the new CDC criteria, after ruling out cellulitis, only 24 (2.6%) were found to have SSIs. A total of 12.5% of the SSIs were detected during follow-up. Acinetobacter baumannii was the predominant organism as also Staphylococcus aureus. Outcomes observed included changes in antibiotic regime, revision surgery, readmission to hospital and deaths.

Conclusion:
SSI is prevalent in orthopaedic trauma patients and an active surveillance program will help in early management and prevention.
The Plot of the Plot:
Authors: Wulfman Clifford E. 
Published: August 2014

ABSTRACT
Data visualizations, particularly in the form of word maps and plotted graphs, have become a hallmark of the so-called “digital humanities.” It is important for creators and readers of these depictions to remember that they are not “data” but readings, interpretations of data mediated by programmed algorithms and hermeneutic desires. More important for periodical studies than plots of nodes and edges is the immense graph of the so-called “Semantic Web,” whose network of machine-actionable assertions could enable researchers to combine statements about magazines into rich interpretive maps.
A Modern Theory of Stasis
Authors: Hoppmann Michael J. 
Published: August 2014

Abstract
This article revisits stasis theory, the rhetorical tool that outlines the strategic options of a defendant in a moral or legal accusation. By analyzing the burden of proof of an accuser and deducing a comprehensive model for a modern theory of stasis from the resulting obligations, it develops a system of ten vital staseis (key issues), each of which is by itself sufficient for a defense in front of a reasonable audience. The resulting modern theory of stasis can be a useful heuristic tool for the rhetorical defense against moral and legal accusations as well as for the systematic analysis of judicial speeches and debates.
Different Culture Conditions Modulate the Immunological Properties of Adipose Stem Cells
Authors: Patrikoski Mimmi , Sivula Jyrki , Huhtala Heini , Helminen Mika , Salo Fanny , Mannerström Bettina , Miettinen Susanna 
Published: August 2014

Abstract
The potential of human adipose stem cells (ASCs) for regenerative medicine has received recognition owing to their ease of isolation and their multilineage differentiation capacity. Additionally, low immunogenicity and immunosuppressive properties make them a relevant cell source when considering immunomodulation therapies and allogeneic stem cell treatments. In the current study, immunogenicity and immunosuppression of ASCs were determined through mixed lymphocyte reactions. The immunogenic response was analyzed after cell isolation and expansion in fetal bovine serum (FBS), human serum (HS)-supplemented medium, and xeno-free and serum-free (XF/SF) conditions. Additionally, the immunophenotype and the secretion of CXC chemokine ligand 8 (CXCL8), CXCL9, CXCL10, C-C chemokine ligand 2 (CCL2), CCL5, interleukin 2 (IL-2), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor-α, interferon-γ, transforming growth factor-β1, indoleamine 2,3-deoxygenase, Galectin-1, and Galectin-3 were analyzed. The results showed that ASCs were weakly immunogenic when expanded in any of the three conditions. The significantly strongest suppression was observed with cells expanded in FBS conditions, whereas higher ASC numbers were required to display suppression in HS or XF/SF conditions. In addition, statistically significant differences in protein secretion were observed between direct versus indirect cocultures and between different culture conditions. The characteristic immunophenotype of ASCs was maintained in all conditions. However, in XF/SF conditions, a significantly lower expression of CD54 (intercellular adhesion molecule 1) and a higher expression of CD45 (lymphocyte common antigen) was observed at a low passage number. Although culture conditions have an effect on the immunogenicity, immunosuppression, and protein secretion profile of ASCs, our findings demonstrated that ASCs have low immunogenicity and promising immunosuppressive potential whether cultured in FBS, HS, or XF/SF conditions.
Concise Review: Dedifferentiation Meets Cancer Development: Proof of Concept for Epigenetic Cancer
Authors: Yamada Yosuke , Haga Hironori , Yamada Yasuhiro 
Published: August 2014

Abstract
The technology for generation of induced pluripotent stem cells (iPSCs) has made significant contributions to various scientific fields, and the field of cancer biology is no exception. Although cancer is generally believed to develop through accumulation of multiple genetic mutations, there is increasing evidence that cancer cells also acquire epigenetic abnormalities during development, maintenance, and progression. Because the epigenetic status of somatic cells changes dynamically through reprogramming, iPSC technology can be utilized to actively and globally alter the epigenetic status of differentiated cells. Using this technology, a recent study has revealed that some types of cancer can develop mainly through disruption of the epigenetic status triggered by dedifferentiation. In this paper, we outline the reprograming process and the epigenetic mechanism associated with the maintenance or conversion of cell identity. We then describe several observations suggesting that dedifferentiation can play an important role in cancer development. Finally, we introduce the system responsible for in vivo reprogramming to demonstrate the involvement of dedifferentiation-driven epigenetic disruption in cancer development, and propose that particular types of cancer can develop predominantly through epigenetic alterations.
Dual‐Crosslinked Bioactive Hydrogel Scaffold for Accelerated Repair of Genital Tract Defect
Authors: Wang Liyang , Cheng Leong Chi , Chen Yu , Zhai Huajuan , Chen Zhiyong , Ren Tingting , Xu Leimei , Ding Jiandong , Qiu Junjun , Hua Keqin , Yu Lin 
Published: August 2024

AbstractReproductive health concerns like Mayer‐Rokitansky‐Küster‐Hauser (MRKH) syndrome are prevalent in today's society. MRKH syndrome is a condition that severely affects women's sexual life, fertility, and mental health and has a high prevalence of one out of 5000 female births. Vaginoplasty is the primary method to regain patients’ reproductive health. However, conventional vaginoplasty faces various challenges, including complex and non‐customized treatment procedures causing intense pains and complications. To bring new advances to vaginoplasty, a 3D‐printed hydrogel scaffold is developed to provide satisfactory mechanical support and bioactivity for accelerating defect repair after surgery. The hydrogel scaffold consisting of gelatin methacryloyl (gelMA) and carrageenan (Car) is custom 3D‐printed using an ambient temperature printing system. Furthermore, the scaffold undergoes dual‐crosslinking through chemical crosslinking of gelMA and ionic crosslinking of Car with magnesium ions (Mg2+). This dual‐crosslinking strategy substantially improves the overall mechanical properties of the scaffold and introduces bioactive Mg2+. The sustained release of Mg2+ plus the extracts from the dual‐crosslinked scaffold significantly promotes cell proliferation, migration and angiogenesis. In a preclinical rat model with penetrating genital tract defects mimicking vaginoplasty, the implantation of dual‐crosslinked scaffold repairs the penetrating wounds to near‐normal levels within one week, showing potential as an alternative for better regaining reproductive health.
Supramolecular Cucurbit[5]uril Modulates the Buried SnO2/Perovskite Interface for Efficient and Stable Perovskite Solar Cells
Authors: Long Zhihao , Peng Cheng , Dong Kaiwen , Jiang Haokun , Zhu Mingzhe , Yan Wenjian , Dong Yufei , Jiang Wenjuan , Wen Lirong , Jiang Xiaoqing , Zhou Zhongmin 
Published: August 2024

AbstractReducing non‐radiative recombination caused by defects at buried interfaces is crucial to the development of efficient and stable perovskite solar cells (PSCs). Herein, supramolecular cucurbit[5]uril (CB[5]) is introduced into the SnO2 layer, where it engages in host–guest interactions to suppress oxygen vacancies in SnO2, prevent particle aggregation, and enhance the electron mobility of SnO2. By serving as a bridging agent at the buried interface between SnO2 and the perovskite layer, CB[5] reduces the defect density and improves the carrier extraction efficiency. It also enhanced the surface energy of the SnO2 substrate, facilitates the formation of large grains in the perovskite film, alleviates residual lattice stresses, and enhances the film quality. Consequently, the PSC with CB[5] shows a champion power conversion efficiency of 24.83%. Moreover, an unencapsulated device incorporating CB[5] retains more than 87% of its initial PCE under continuous illumination at the maximum power point tracking for 1000 h. This study pioneers the utilization of cucurbiturils in PSCs and provides insights into how supramolecular compounds can regulate buried interfaces.
Strong Electrostatic Control of Excitonic Features in MoS2 by a Free‐Standing Ultrahigh‐κ Ferroelectric Perovskite
Authors: Pucher Thomas , Puebla Sergio , Zamora Victor , Sánchez Viso Estrella , Rouco Victor , Leon Carlos , Garcia‐Hernandez Mar , Santamaria Jacobo , Munuera Carmen , Castellanos‐Gomez Andres 
Published: August 2024

AbstractIntegrating free‐standing complex oxides with two‐dimensional (2D) materials has recently attracted great interest, due to the rich physics evolving from such structures. Enhancing and tuning the opto–electronic properties of these systems is of high importance for a multitude of applications, such as sensors, memory devices or optical communications. The electrostatic control of photoluminescence of monolayer MoS2 at room temperature via integration of free‐standing BaTiO3 (BTO), a ferroelectric perovskite oxide is presented. It is shown that the use of BTO leads to highly tunable exciton emission of MoS2 in a minimal range of gate voltages. Due to BTO's ferroelectric polarization‐induced doping, large peak emission shifts as well as a large and tunable A trion binding energy in the range of 40–100 meV are observed. These measurements are compared with those carried out when the BTO is replaced by a hexagonal boron nitride (hBN) dielectric layer, confirming BTO's superior gating properties and thus lower power consumption. Additionally, advantage of the ferroelectric switching of BTO is taken by fabricating devices where the BTO layer is decoupled from the gate electrode with a SiO2 layer. Choosing to isolate the BTO allows to induce large remanent behavior of MoS2’s excitonic features.
Anchoring Ultralow Platinum by Harnessing Atomic Defects Derived from Self‐reconstruction for Alkaline Hydrogen Evolution Reaction
Authors: Ma Hancheng , Peng Wei , Wong Hoilun , Guo Xuyun , Xu Lin , Tamtaji Mohsen , Ding Yao 
Published: August 2024

AbstractThe sluggish kinetics of alkaline hydrogen evolution reaction (HER) hinders practical exploitation of water splitting. Catalysts, known as platinum single atoms (Pt‐SAs) anchored in Ni4Mo/Ni alloys on nickel foam (Pt SAs‐Ni4Mo/Ni@NF) with ultralow Pt mass loading (mPt = 0.3 wt.%) derived from self‐reconstruction, with boosted atomic utilization in alkaline HER are demonstrated. In situ characterizations confirm the leaching of Mo species during the self‐reconstruction of NiMoO4, which facilitates the anchoring of Pt‐SAs through the generation of atomic defects. Further, density functional theory (DFT) calculations indicate that the atomic defects can effectively capture Pt2+ in salt solution, aiding in the distribution of Pt‐SAs. Besides, theoretical results emphasize that Pt SAs‐Ni4Mo/Ni with unique Pt‐Ni interaction can accelerate the desorption of hydroxides in alkaline electrolytes during HER, as well as lower energy barriers for reaction steps. Pt SAs‐Ni4Mo/Ni@NF shows remarkable catalytic activity toward alkaline HER with a low overpotential of 17 mV (j = 10 mA cm−2), together with high atomic utilization of Pt (8.92 A mgPt−1 at 30 mV) and excellent durability. This work not only provides a scalable preparation for efficient and robust low‐Pt catalysts but also establishes in‐depth understanding of the synergistic interaction between Pt SAs and Ni‐Mo alloys in alkaline HER, which is likely to accelerate the development of water‐splitting technique.
Chemically Tailored Metal‐Organic Frameworks for Enhanced Capture of Short‐ and Long‐Chain Per‐ and Polyfluoroalkyl Substances from Water
Authors: Loukopoulos Edward , Marugán‐Benito Sergio , Raptis Dionysios , Tylianakis Emmanuel , Froudakis George E. , Mavrandonakis Andreas , Platero‐Prats Ana E. 
Published: August 2024

AbstractPer‐ and polyfluoroalkyl substances (PFAS) are emerging as bioaccumulative and toxic water pollutants, posing a large threat to human and aquatic organisms. This threat is aggravated by their extreme persistence to common degradation methods. Adsorption is regarded as the most conventional method to treat these contaminants, however, existing sorbents present considerable limitations on performance. The development of more efficient PFAS adsorbents is therefore of urgent need. The class of metal‐organic frameworks (MOFs) can hold great promise for these purposes, featuring porous materials with high tailoring potential. Herein, a series of functionalized Zr‐MOFs have been designed with boosted capacities for the adsorption of short‐ and long‐chain perfluorinated carboxylic acids of environmental interest. The approach relies on chemistry‐based concepts to introduce targeted post‐synthetic modifications that promote PFAS···MOF interactions, specifically through coordinative bonding and hydrophobic effects. In particular, the framework TFA‐MOF‐808 (TFA = trifluoroacetic acid) displays the highest capture capacities reported for MOF materials in this pollutant class. Mechanistic studies, assisted by advanced synchrotron characterization techniques and theoretical calculations, support a ligand exchange process occurring during the adsorption phenomena. The results demonstrate the potential of this design approach in developing advanced PFAS sorbents with optimal performance.
Untethered Microgrippers for Biopsy in the Upper Urinary Tract
Authors: Liu Wangqu , Alam Ridwan , Choi Si Young , Wan Yan , Zhang Ruili , Baraban Ezra , Matoso Andres , Matlaga Brian R. , Winoker Jared S. , Gracias David H. 
Published: August 2024

AbstractUntethered microrobots offer the possibility to perform medical interventions in anatomically complex and small regions in the body. Presently, it is necessary to access the upper urinary tract to diagnose and treat Upper Tract Urothelial Carcinoma (UTUC). Diagnostic and treatment challenges include ensuring adequate tissue sampling, accurately grading the disease, achieving completeness in endoscopic treatment, and consistently delivering medications to targeted sites. This work introduces microgrippers (µ‐grippers) that are autonomously triggered by physiological temperature for biopsy in the upper urinary tract. The experiments demonstrated that µ‐grippers can be deployed using standard ureteral catheters and maneuvered using an external magnetic field. The μ‐grippers successfully biopsied tissue samples from ex vivo pig ureters, indicating that the thin‐film bilayer springs' autonomous, physiologically triggered actuation exerts enough force to retrieve urinary tract tissue. The quality of these biopsy samples is sufficient for histopathological examination, including hematoxylin and eosin (H&E) and GATA3 immunohistochemical staining. Beyond biopsy applications, the µ‐grippers' small size, wafer‐scale fabrication, and multifunctionality suggest their potential for statistical sampling in the urinary tract. Experimental data and clinical reports underscore this potential through statistical simulations that compare the efficacy of µ‐grippers with conventional tools, such as ureteroscopic forceps and baskets.
A Pyroptosis‐Inducing Arsenic(III) Nanomicelle Platform for Synergistic Cancer Immunotherapy
Authors: Wang Xing , Tang Yuqi , Li Yuanhang , Qi Zhengjian 
Published: August 2024

AbstractImmunogenic cell death (ICD) could activate anti‐tumor immune responses, which is highly attractive for improving cancer treatment effectiveness. Here, this work reports a multifunctional arsenic(III) allosteric inhibitor Mech02, which induces excessive accumulation of 1O2 through sensitized biocatalytic reactions, leading to cell pyroptosis and amplified ICD effect. After Mech02 is converted to Mech03, it could actualize stronger binding effects on the allosteric pocket of pyruvate kinase M2, further interfering with the anaerobic glycolysis pathway of tumors. The enhanced DNA damage triggered by Mech02 and the pyroptosis of cancer stem cells provide assurance for complete tumor clearance. In vivo experiments prove nanomicelle Mech02‐HA NPs is able to activate immune memory effects and raise the persistence of anti‐tumor immunity. In summary, this study for the first time to introduce the arsenic(III) pharmacophore as an enhanced ICD effect initiator into nitrogen mustard, providing insights for the development of efficient multimodal tumor therapy agents.
Ultra Low Power Consumption Optoelectronic Logic Operation of CuO/BaTiO3 Heterojunction Photodetector with Tunable Internal Electric Field Based on Poling Effect
Authors: Cho Junhyung , Choi Wangmyung , Park Taehyun , Yoo Hocheon 
Published: August 2024

AbstractThe study presents a novel self‐powered ultraviolet (UV) photodetector harnessing both polarization fields and photovoltaic effects, enabling the realization of ultra‐low power, reconfigurable optoelectronic logic gates. The approach is demonstrated on a CuO/BaTiO3 heterojunction photodetector. The behavior of the photodetector is augmented by the poling effect, aligning the internal electric field of the BaTiO3 through the application of a robust external electric field, thereby facilitating the implementation of optoelectronic logic gates. In the unpoled state, the “XOR” and “OR” logic gates operated at voltages of 750 and −500 µV, respectively. However, upon poling up state, the “XOR” logic gate exhibits reduced operation voltage, operating at 500 µV, while the “OR” logic gate implements clarity at −500 µV. In the unpoled state the “AND” logic gate does not operate; however, upon poling in the downward direction, it operated at −500 µV. The achievement demonstrates successful ultra‐low‐power logic operations, utilizing voltages in the hundreds of micron scale, under a 310 nm wavelength and a light intensity of 0.52 mW·cm−2. Furthermore, controllable polarization electric fields in BaTiO3 enable the operation of “AND” logic gate in the unpoled state, presenting a promising avenue for future research in optoelectronic logic gate design.