bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediastinal Hemangioma Mimicking as Bronchial NET
Authors: Kar Siven , Gupta Harshita , Shaikh Nusrat , Lele Vikram 
Published: August 2024

Abstract
We present a rare case of mediastinal capillary hemangioma in a 54-year-old female. She presented with back pain in the left suprascapular region, and the chest radiograph revealed left pleural effusion. On further workup with high-resolution computed tomography (CT) chest, a hypervascular pleural-based neoplastic lesion in the left upper hemithorax with gross left pleural effusion and subtotal collapse of the left lung was identified. 18F-fluorodeoxyglucose positron emission tomography/CT was suggestive of a weakly metabolic well-defined pleural-based soft tissue lesion in the left upper hemithorax along the mediastinal side. Neuroendocrine tumor was suspected. 68Ga-DOTATATE PET/CT was advised, which showed intense uptake in the lesion. The mass was resected completely. Histopathological examination established the final diagnosis as benign vascular tumor consistent with a capillary hemangioma.
Rare Cases of Extracranial Metastases from High-grade Glioma Detected on FET PET-CT with Histopathological Confirmation
Authors: Dev Indraja Devidas , Sahay Ayushi , Puranik Ameya D. , Purandare Nilendu C , Agrawal Archi , Shah Sneha , Choudhury Sayak , Ghosh Suchismita , Rangarajan Venkatesh 
Published: August 2024

Abstract
Extracranial metastasis from high-grade glial tumors is an extremely rare condition with its reported incidence being <1%. The most common sites reported in the literature are leptomeninges and spinal cord, followed by the liver, lung, and skeletal system. Its low incidence is thought to be related to the intrinsic aggressive biology of the tumor, thus reducing median overall survival in patients. As there is lack of knowledge about the mechanism of extracranial spread of glioma cells, its diagnosis and management remain a major challenge. We report two cases of extracranial metastases from glial tumors to cervical nodes and postoperative site involving preauricular region detected on F18 Fluoro ethyl tyrosine (FET) positron emission tomography–computed tomography and later on confirmed with histopathology Fluoro ethyl tyrosine.
An Unusual Occurrence of Metastases to Multiple Muscles in Neuroblastoma
Authors: Khan Dikhra , Sagar Sambit , Shamim Shamim Ahmed , Kaushik Prateek , Kumar Rakesh 
Published: August 2024

Abstract
Neuroblastoma presenting with multiple muscles and subcutaneous tissue metastases is rarely reported in the literature. We would like to highlight such infrequent occurrences for increasing the clinical acumen of the medical fraternity with an aim to deliver proper therapy to patients.
Unexpected Extrarenal Accumulation of Tc-99m Ethylene Dicysteine in a Case of Liposarcoma
Authors: Jamshidi Zahra , Hekmat Sepideh , Hassanzadeh Leila 
Published: August 2024

Abstract
The technetium-99m ethylene dicysteine (Tc-99m EC) is a radiopharmaceutical used for renal scintigraphy, a noninvasive imaging technique that assesses kidney function as well as urinary tract obstruction. We describe the extrarenal Tc-99m EC uptake in a 70-year-old man with recurrent well-differentiated abdominal liposarcoma. In the present case, both liposarcoma lesions which were diagnosed by abdominal CT scan showed heterogeneous accumulation of the Tc-99m EC.
[18F]FDG PET/CT in Benign and Malignant Diseases Involving the Biliary Tract
Authors: Prabhu Meghana , Nisamudeen Fahad , Vikas H 
Published: August 2024

Abstract
Role of FDG PET/CT in evaluation of biliary tract diseases remains relatively unexplored. PET/CT with FDG helps in evaluation of both infective / inflammatory as well as neoplastic diseases as increased glucose utilization is observed in both the conditions. In this article, we describe the spectrum of FDG PET/CT findings in various diseases affecting the biliary tract. Role of FDG PET/CT in neoplastic diseases involving the biliary duct has been described at the time of staging and response evaluation; in characterization of the intrahepatic mass (abscess v/s cholangiocarcinoma). In addition, we have discussed about the false positive FDG uptake along the biliary duct stent, which interfere with scan interpretation. Few of the benign conditions described are Langerhans cell histiocytosis and IgG4 related disease involving the biliary duct and adenomyomatosis and Xanthogranulomatous cholecystitis involving the gall bladder.
An Analysis of the Diagnostic Performance of Tc-99m PSMA SSPECT/CT in Biochemically Recurrent Prostate Cancer Compared with Ga-68 PSMA PET/CT: A Single-center, Prospective Study
Authors: Ora Manish , Saini Vivek Kumar , Dixit Manish , Singh Uday Pratap , Gambhir Sanjay 
Published: August 2024

Abstract

Objective:
Biochemical recurrence (BCR) after initial management of Prostate Carcinoma (PC) is frequent. Subsequent interventions rely on disease burden and metastasis distribution. 68Ga prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) is an excellent imaging modality in BCR. However, 68Ga is radionuclide generator produced and has restricted availability. 99mTc-labeled PSMA could be a potential cost-effective alternative. We compared the performance of 99mTc-PSMA single-photon emission CT (SPECT)/CT and 68Ga-PSMA PET/CT in BCR with a serum prostate surface antigen (PSA) level of <20 ng/mL.

Materials and Methods:
The prospective study included 25 patients with BCR and at least one lesion on a 68Ga-PSMA PET/CT. All patients underwent 99 mTc-PSMA SPECT/CT, and disease distribution and metastatic burden were compared with 68Ga-PSMA PET/CT. The maximum standard uptake value (SUVmax) and the tumor-to-background ratio (TBR) were computed and analyzed.

Results:
The mean age and serum PSA (SPSA) were 69.72 ± 6.69 years and 5.65 ± 6.07 ng/mL. Eleven patients (44%) had SPSA ≤2 ng/mL. Recurrent sites were noted in the prostate (19, 76%), prostatic bed (3, 12%), and pelvis lymph nodes (LNs) (13, 52%). Distant metastasis to bones (13, 52%), lungs (5, 20%), and retroperitoneal LNs (2, 8%) were noted. Both modalities were concordant for the recurrent disease at the prostate, prostatic bed, bone, and lung lesions. 99mTc-PSMA could localize pelvis LNs in most patients (10/13, 76.9%). The site-specific sensitivity and specificity between the two modalities were not significantly different (P > 0.05). TBR shows excellent correlation with SUVmax (0.783, P < 0.001). Four (16%) patients were understaged with 99mTc-PSMA due to the nonvisualization of the subcentimeter size LNs. No patient with systemic metastases was understaged.

Conclusions:

99mTc-PSMA SPECT/CT has good concordance with 68Ga-PSMA PET/CT in BCR, even at low PSA levels. However, it may miss a few subcentimeter LNs due to lower resolution. 99mTc-PSMA SPECT/CT could be a simple, cost-effective, and readily available imaging alternative to PET/CT.
Comparison of neutral and sniffing position for ease of endotracheal intubation using Airtraq optical laryngoscope-A randomized trial
Authors: Bhardwaj Mamta , Priya  , Rashmi  , Kumar Prashant , Kaur Kiranpreet , Sunny  
Published: August 2024

Abstract

Background:
Traditionally, the sniffing position has been considered a standard head and neck position during direct laryngoscopy. The perfect head and neck position for video laryngoscopy has yet not been described. Hence, we planned the present study to compare the neutral and sniffing position for ease of intubation using Airtraq.

Methods:
A total of 60 patients were randomized into two groups. Patients were intubated with their heads in neutral and sniffing positions in Group NP and SP, respectively. Ease of intubation was taken as a primary outcome. Laryngoscopy time, intubation time, percentage of glottic opening (POGO), the number of attempts for Airtraq and endotracheal tube, insertion of Airtraq, the success rate of intubation, optimization maneuvers, and complications were taken as secondary objectives. Data were analyzed using SPSS software, V.22.(1).

Results:
For ease of intubation, we used a visual analog scale (VAS) and Fremantle scores. VAS score (mm) in the median (interquartile range [IQR]) was 32 (24, 34) and 28 (24, 32) in NP and SP groups, respectively (P = 0.37). Twenty-four (80%) patients in NP and 23 (76.67%) patients in the SP group had a Fremantle score of F1 (full view; easy intubation). One (3.33%) patient in both groups had a score of F2 (full view; modified intubation). Five (16.67%) and six (20%) patients in NP and SP groups had P1 scores. Overall, there was no difference in Fremantle’s score between the groups (P = 0.945). The number of attempts, optimization maneuvers, and complications were statistically comparable between the groups.

Conclusion:
There is no difference in the ease of intubation between the neutral and sniffing position using the Airtraq optical laryngoscope.
Evaluation of efficacy of oral ivabradine for attenuation of hemodynamic response to intubation in hypertensive surgical patients: Effect on rate pressure product as an index of myocardial oxygen demand
Authors: Naithani Udita , Ahamed Riyaz K. , Jain Shweta , Gakkhar Vandana , Garg Isha , Saxena Gaurav 
Published: August 2024

Abstract

Background and Aims:
An exaggerated hemodynamic response to endotracheal intubation is observed in hypertensive patients, and its attenuation proves challenging. The role of oral ivabradine, a unique heart rate-lowering drug with a favorable hemodynamic profile, is not yet studied. The aim of this study was to evaluate the effect of oral ivabradine on the attenuation of hemodynamic response to endotracheal intubation in hypertensive surgical patients assessed by rate pressure product (RPP), which is a very reliable indicator of myocardial oxygen demand.

Material and Methods:
Sixty medically controlled hypertensive surgical patients, aged 30–65 years, receiving general anesthesia were divided into two equal groups: Group I received a tablet of ivabradine 5 mg and group C received a placebo tablet 1 hour before induction. Heart rate (HR) and systolic, diastolic, and mean arterial blood pressure (SBP, DBP, and MAP) were recorded at baseline, preoperative, immediately after intubation, 1 min, 3 min, 5 min, and 10 min following intubation. RPP was calculated at the above time intervals. Data were analyzed using the unpaired t-test and the Chi-square test as required, with P < 0.05 considered significant.

Results:
The maximum value of RPP after intubation was significantly less in group I (11065.64 ± 606.56) as compared to group C (16774.64 ± 1242.87), P = 0.000. All hemodynamic variables, RPP, HR, SBP, DBP, and MAP, remained significantly less in group I than group C at all time intervals (P = 0.000). These parameters never increased above baseline after intubation in the ivabradine group, indicating effective attenuation of the intubation response.

Conclusion:
Premedication with oral ivabradine 5 mg is very effective in attenuating the hemodynamic response to intubation in hypertensive patients.
Comparative evaluation of oral premedication with clonidine and metoprolol on surgical field conditions and intraoperative hemodynamics during functional endoscopic sinus surgery
Authors: Naithani Udita , Verma Priya , Ahamed Riyaz K. , Choudhary Santosh , Gakkhar Vandana , Deshpande Gayatri 
Published: August 2024

Abstract

Background and Aims:
Bloodless surgical field during functional endoscopic sinus surgery (FESS) is an essential part, and research continues to find simple and effective regime for it. This study was aimed to compare the efficacy of oral clonidine versus oral metoprolol as premedicants regarding surgical field condition and controlled hypotension in patients undergoing FESS.

Material and Methods:
Sixty-eight patients of American Society of Anesthesiologists (ASA) physical status (PS) I and II aged 18–60 years, of both genders, scheduled for FESS under general anesthesia were randomly allocated in two groups. Group C (n = 34) received oral clonidine 300 μg and group M (n = 34) received oral metoprolol 50 mg, 2 h before surgery. Controlled hypotension (mean arterial pressure [MAP] 65–75 mmHg) was achieved by titrating sevoflurane (1%–3%). Primary outcome measured was surgical field visualization by Average Category Scale (ACS 0–5), and the secondary outcomes measured were hemodynamic parameters, sevoflurane requirement, recovery, and side effects. Categorical, continuous, and ordinal data were compared using Chi-square test, t-test, and Mann–Whitney test, respectively. P < 0.05 was considered as statistically significant.

Results:
ACS was significantly less in group C compared to group M up to 60 min, (P < 0.05). Mean systolic blood pressure (SBP), diastolic blood pressure (DBP), and MAP were significantly less in group C compared to group M at all time intervals (P < 0.05) Intraoperative sevoflurane requirement (vol %) was significantly less in group C (1.21 ± 0.42) compared to group M (1.68 ± 0.53) (P = 0.000).

Conclusions:
Premedication with oral clonidine was found to be superior to oral metoprolol as it provided significantly better surgical field condition during FESS with much efficient controlled hypotension and anesthetic-sparing effect.

Standardized Study Reporting Requirements: CONSORT: http://www.consort-statement.org/.
Impact of sevoflurane anesthesia on S-adenosylmethionine in neonates under general anesthesia
Authors: Nagappa Saraswathi , Kalappa Sandhya , Sridhara Raghavendra B. , Biligi Dayananda S. , Annapoorneshwari R , Ramachandraiah  
Published: August 2024

Abstract

Background and Aims:
Preclinical studies in rodents and primates have shown that anesthesia was neurotoxic to the developing brain after exposure in the neonatal period. Sevoflurane a commonly used inhalational anesthetic, especially in pediatric surgery, might cause behavioral impairment in the developing brain. Although favored for its rapid onset and minimal airway disturbance, sevoflurane has been implicated in neurotoxic effects such as anesthesia-induced developmental neurotoxicity in rodents, through various mechanisms. One of the mechanisms was disturbances in methylation metabolism which can be easily treated if it is proved. This study aims to evaluate the levels of S-adenosylmethionine [SAM] following sevoflurane anesthesia in neonates and to correlate the duration of sevoflurane exposure and S-adenosylmethionine levels.

Material and Methods:
Sixty neonates were included in the study under general anesthesia. Pre- and postsevoflurane exposure arterial blood samples were collected in ethylenediamine tetraacetic acid vacutainers. Each sample was centrifuged at 1000 rpm for 10 min. Plasma was separated and stored at −80°C, then subjected to S-adenosylmethionine enzyme-linked immunoassay test for preand postsevoflurane exposure levels of SAM.

Results:
The difference between the pre- and post-SAM values is not statistically significant and also with increasing the duration of sevoflurane exposure there was no reduction in the SAM levels (r = 0.17), and the correlation was not significant (P = 0.18).

Conclusion:
Single exposure to sevoflurane does not impact SAM levels in neonates undergoing general anesthesia.
Dimensions of Psychological Wellbeing as Predictors of Stress among Undergraduates
Authors: Obi-Nwosu Harry , Onuoha Okechukwu Christian , Obi-Nwosu Victoria Ogochukwu 
Published: August 2024

Purpose: The purpose of this study was to examine the relationship between dimensions of psychological wellbeing and stress among undergraduates of Nnamdi Azikiwe University, Awka.
Methodology: the study utilized an Ex Post Facto research design with secondary data of one thousand (1000) respondents generated from the platform for psychological assessment of staff and students, developed by Centre for Counselling and Career Development of Nnamdi Azikiwe University, Awka. Multiple regression analysis was used for analysis at .001, and .05 levels of significance.
Findings: From the purpose of the study and research questions, six hypotheses were postulated and tested. The findings indicated that hypotheses 1, 3, and 4 were rejected which means that autonomy, environmental mastery, and purpose in life did not predict stress among undergraduates. Whereas, hypotheses 2, 5, and 6 were accepted indicating that positive relationship with others, personal growth, and self-acceptance predicted stress among undergraduates.
Unique Contributions to Theory, Policy and Practice: Since some dimension of psychological wellbeing (positive relationship with others, personal growth, and self-acceptance) were found to have a direct predictive relationship with stress among undergraduates, the theoretical framework is further validated; hence, the findings in this study could be used for further elaboration of the theoretical framework. Psychotherapist and counsellours would benefit from the findings, since assessment of students among other parameters should take the factors of interpersonal relationship into consideration. Also, psychotherapeutic regiments, directed at improving these domains of PWB will serve both therapeutic and prophylactic purposes.
Effect of foot muscle energy technique in patients with diabetic neuropathy: a randomized controlled trial
Authors: Hammam Radwa Fayek , Alshimy Ahmed Magdy , Mosaad Andrew Anis Fakhrey , Ibrahim Maha Gamal 
Published: August 2024

IntroductionThis study investigated the effect of foot muscle energy technique (MET) on nerve conduction velocity (NCV) and isometric muscle strength in patients with type 2 diabetic neuropathy (DN).MethodsForty-four patients were randomly assigned to either the MET group (group A) or the conventional physical therapy program group (group B). Electrophysiological measurements, including peroneal and tibial motor NCV studies, and isometric muscle strength using a toe strength dynamometer, were conducted. The assessment period ranged from April to November 2022, with measurements taken before the first session and after 4 weeks of treatment.ResultsSignificant improvements were observed in post-treatment peroneal motor NCV (<i>p</i> < 0.001), tibial motor NCV (<i>p</i> < 0.001), and isometric muscle strength (<i>p</i> < 0.001) in group A, but not in group B.ConclusionsMET enhances motor NCV and isometric muscle strength in patients with type 2 DN.
Avaliação da eficácia de suplementos imunoestimulantes no tratamento e prevenção do resfriado comum
Authors: Godinho João Thales Azevedo , Soares Filho Fábio Braga 
Published: August 2024

O uso de terapias alternativas para cura ou prevenção de infecções virais respiratórias era difundido entre os povos antigos. No entanto, embora haja falta de evidências sobre a eficácia dessas terapias diversas, atualmente, uma ampla variedade de imunoestimulantes naturais está associada a esses benefícios. A presente revisão avalia a eficácia do uso de diferentes imunoestimulantes naturais na prevenção e tratamento de infecções do trato respiratório superior, como resfriados e gripe. Foi realizada uma revisão integrativa da literatura utilizando bases de dados como PubMed, Scielo e MedLine. Utilizamos vários termos de busca em ciências da saúde, como "Echinacea", "Ascorbic Acid", "Vitamin C", "Zinc", "Sambucus", "Elderberry", "Garlic", "Common Cold", "Prevention", "Complementary Therapies" e "Phytotherapy", combinados com os operadores booleanos "AND" e "OR". Após a seleção criteriosa, 15 artigos foram escolhidos para compor a revisão. Os dados sobre os efeitos do uso de terapias alternativas com imunoestimulantes para alívio e prevenção de sintomas do resfriado comum são conflitantes. Embora a combinação dessas terapias com tratamentos antivirais possa ser benéfica, há limitações em relação à qualidade e quantidade de estudos disponíveis. Enquanto terapias com vitamina C, alho e equinácea carecem de evidências robustas sobre sua eficácia no alívio ou prevenção de sintomas respiratórios, o extrato de sabugueiro e o zinco mostraram potencial promissor na redução da gravidade e duração de resfriados. No entanto, mais pesquisas científicas são necessárias para melhor compreender os benefícios e limitações dessas abordagens terapêuticas alternativas no manejo do resfriado comum.
O componente curricular de educação tecnológica nos anos finais do ensino fundamental: potencialidades exploradas pelos professores da rede de ensino SESI Ceará
Authors: Silveira Mateus Marcos Silva da , Félix Hangley da Silva , Melo Carlos Eduardo Costa , Souza Andrea Moura da Costa , Almeida Emanoel Rodrigues , Pereira Douglas Washington Carioca , Silva Amanda Ferreira da , Cavalcante Gervânia Sampaio 
Published: August 2024

O presente artigo apresenta as potencialidades exploradas pelos professores de disciplinas específicas que atuam também como professores de Educação Tecnológica nos anos finais do Ensino Fundamental na Rede de Ensino do Serviço Social da Indústria (SESI), para isso investigou-se as principais ferramentas e recursos utilizados no desenvolvimento das aulas de educação tecnológica. Essa pesquisa é qualitativa, exploratória com o uso de questionário de perguntas objetivas e subjetivas aplicados pelo google forms. A pesquisa baseou-se na resposta de 15 professores. Identificou-se que eles reconhecem a importância do uso da tecnologia na educação e faz uso de variados recursos e ferramentas digitais como suporte para o ensino. A pesquisa também revelou que o uso das tecnologias tem um impacto positivo no desempenho e engajamento dos estudantes e a maioria dos docentes reconhecem também esse impacto. Alguns professores demonstraram necessidade de mais formações em novas tecnologias, mas reconhecem que a Rede SESI tem ofertado formações aos educadores que foram fundamentais para alavancar práticas pedagógicas inovadoras. Conclui-se que a atuação do Programa SESI ao usar a metodologia STEAM e integrar a Educação tecnológica a disciplina específica, não apenas promoveu diversas potencialidades na inovação das práticas pedagógicas, mas também inseriu digitalmente os alunos. A pesquisa conclui que a integração eficaz dessa disciplina promove aprendizagem colaborativa, pensamento crítico e habilidades tecnológicas essenciais, contribuindo significativamente para a educação.
IMPLEMENTATION OF THE EXAMPLE METHODS OF MACHELORAL ACHIEVEMENT TEACHERS IN IMPROVING STUDENTS' CHARACTERIAL ACHIEVEMENT AT MADRASAH TSANAWIYAH NURUL WALIDAIN CIAMPEA BOGOR
Authors: Samsuddin Samsuddin 
Published: August 2024

This research aims to determine the application of the aqidah akhlak teacher's exemplary method in improving students' morals (akhlakul karimah) at Madrasah Tsanawiyah Nurul Walidain Ciampea Bogor. The method used in this research is qualitative, while the data collection method is carried out through observation, interviews and documentation. The existing data was analyzed using interpretative descriptive methods. The results of this research indicate that the application of the moral aqidah teacher's exemplary method in improving students' morals at Madrasah Tsanawiyah Nurul Walidain is going well and effectively. Through this research, it was revealed that the example of the moral aqidah teacher is effective in improving students' morals, because students are not only given theory but there is an example from the moral aqidah teacher. However, students gain examples from teachers of moral beliefs who become role models in everyday life.