bluuebunny/crossref_metadata_2025_split huggingface dataset:
Singularities of spherical surface in R4
Authors: Liu Haiming , Hua Yuefeng , Li Wanzhen 
Published: August 2024

Abstract
In this article, we mainly study the geometric properties of spherical surface of a curve on a hypersurface

Σ

\Sigma

in four-dimensional Euclidean space. We define a family of tangent height functions of a curve on

Σ

\Sigma

as the main tool for research and combine the relevant knowledge of singularity theory. It is shown that there are three types of singularities of spherical surface, that is, in the local sense, the spherical surface is respectively diffeomorphic to the cuspidal edge, the swallowtail, and the cuspidal beaks. In addition, we give two examples of the spherical surface.
Characteristics and Distribution of Chemical-Biological Parameters in The Seawaters of Eastern Java Sea
Authors: Pambudi Achmad Yogi , Putra Muhamad Gilang Arindra , Yogaswara Deny , Yuliardi Amir Yarkhasy 
Published: August 2024

The Java Sea is influenced by the west and east monsoons, which have an impact on hydrodynamic processes and chemical-biological water quality. Chemical-biological parameters play an important role in the food chain cycle that occurs in these waters. The quality of the eastern Java Sea waters is still limited by chemical-biological parameters, so the characteristics and distribution of these waters can be comprehensively known. chemical-biological. This study aimed to analyze the characteristics and distribution of nitrate, phosphate, oxygen, chlorophyll-A, and NPP parameters in the eastern Java Sea waters. This study used secondary data with daily temporal resolution from January to December 2020. Spatial analysis uses the climatological averaging method for 6 months as a statistical representative of the west monsoon and east monsoon. For each parameter, a vertical analysis was conducted to compare parameter values between the coastal waters of Tuban, Java Sea, and Banjarmasin Waters. Correlation analysis between parameters was conducted using the Pearson correlation method. Nitrate, phosphate, oxygen, chlorophyll-A, and NPP concentrations have temporal and spatial variability. Monsoon factors in Indonesia have a strong influence on the variability of nitrate, phosphate, oxygen, chlorophyll- A, and NPP concentrations. During the east monsoon, the concentration of chemical-biological parameters decreases, while in the west monsoon, the concentration increases and reaches its highest value. Generally, high concentrations occur in the northern and southern parts of the study site, around the coastal areas of Java and Kalimantan. Key Word: Chemical-Biological Parameters, Java Sea, Tuban Waters
The Influence of Personalized Web-Based Learning on The Mastery and Application of Concepts in Students with Different Learning Styles
Authors: Abdul Haris Indrakusuma  , Setyosari Punaji , Sulton  , Waras  
Published: August 2024

Conventional learning has limitations, leading researchers to propose personalized web-based learning tailored to individual student characteristics. This study focuses on enhancing web-based learning at Bhinneka PGRI University in Indonesia by customizing content and activities to align with students' learning styles. The research methodology uses a quasi-experimental design involving 72 information technology education students. Data collection includes assessments of learning styles, concept mastery, and concept application through tests. Descriptive statistical analysis shows that personalized web-based learning has a more positive influence on the mastery and application of concepts compared to non-personalized learning. There is no significant correlation between personalized web-based learning and students' learning styles. The findings indicate differences in mastery and application of concepts among students using web-based learning, but no disparities based on different learning styles. In conclusion, personalized web-based learning leads to variations in mastery and application of concepts compared to non-personalized methods, with no discernible discrepancy in the mastery and application of concepts between students with different learning styles. Research indicates that personalized web-based learning is more effective in enhancing mastery and application of concepts compared to non-personalized methods. By customizing web-based learning to individual learning styles, students can enhance the quality and outcomes of their learning.
Hamka’s Sufism in The Literary Work “Tenggelamnya Kapal Van Der Wijck” on Schleiermacher’s Hermeneutics Perspective
Authors: Al Farouqy AR. Miftah , Syaifuddin Helmi , Barizi Ahmad 
Published: August 2024

Hamka was a prolific poet scholar who brought the idea of reforming Sufism, known as neo-Sufism. As a poet, he wrote many literary works, such as “Tenggelamnya Kapal Van der Wijck” which was written at the same time as modern Sufism, also contains elements of Sufism. This research aims to (1) identify Hamka's sufistic texts in “The Sinking of van Der Wijck”, (2) analyze the sufistic meaning in it’s work on Schleiermacher's hermeneutic perspective. “Tenggelamnya Kapal Van der Wijck” is one of Hamka's literary works that is considered to contain sufistic values. The authors analyzed the sufistic texts in Schleirmacher’s hermeneutics perspective, a relevant approach to derive the meaning of Hamka’s literary texts. This research is in the form of qualitative research and is categorized as library research with a text analysis method. Data is obtained through documentary techniques, and data sources are taken from books and secondary notes that are relevant to the research theme. The data is then analyzed using Schleiermacher's hermeneutic working principles by means of grammatical and psychological interpretations. The result of this study is (1) Hamka's Sufism in “Tenggelamnya Kapal Van der Wijck” found in the text of the story in the aspects of: natural beauty, a quest for true happiness, good manners, and love. (2) After going through interpretation and analysis stages using perspective of Schleirmacher’s hermeneutics, the meaning of these aspects of sufistic text is love, which is natural giving (fiṭrah), and must be maintained by declaring self to Allah, natural beauty as an introduction to reaching maqām riḍā, good manners as a means of knowing Allah, and true happiness is ma'rifatullāh
Taurine and proline promote lung tumour growth by co-regulating Azgp1/mTOR signalling pathway
Authors: Pan Hu-Dan , Li Run-Ze , Liang Tuliang , Mi Jia-Ning , Ma Gang-Yuan , Xiao Yao , Yang Xi , Huang Chen , Li Jia-Xin , Xie Ying , Yan Pei-Yu , Yao Xiao-Jun , LEUNG Lai Han , Liu Liang 
Published: August 2024

Abstract

Accurate metabolic biomarkers are still scarce and essential for prognosis of lung cancer progression and prognosis. Previous studies have found that two metabolites including taurine and proline are abnormally elevated in lung cancer patients with different stages. This study aimed to elucidate their functional role in lung cancer progression, providing valuable insights into potential therapeutic targets for intervention. Taurine and proline could promote lung tumour growth for the first time, suggesting poor prognosis for lung cancer progression. In transcriptome analysis, both taurine and proline down-regulated the expression of gene Zinc-α2-glycoprotein (Azgp1). Azgp1, down-regulated in lung cancer patients, was significantly associated with key targets of the taurine and proline metabolic pathways. Azgp1 could also significantly affect downstream lipid metabolic pathways in lung cancer. In metabolome analysis, taurine and proline could alter lipid metabolism mediated by mammalian target of rapamycin (mTOR). Moreover, taurine and proline were found to be able to suppress Azgp1 expression and activate mTOR expression. Overexpression of Azgp1, in turn, significantly inhibited lung cancer progression, accompanied by the inhibition of mTOR expression. These results suggested a pro-cancer role of both taurine and proline in lung cancer and identified the Azgp1/mTOR axis as an under-reported pathway involving lung cancer progression.
Factors that facilitate or hinder the use of the facial rehabilitation webtool MEPP 2.0: a comparative study in the Quebecer health system
Authors: Martineau Sarah , Barbeau Jacinthe , Paquin Alyssia , Marcotte Karine 
Published: August 2024

Abstract

Background: Recently, our research team developed an open source and free website called the MEPP website (for the Mirror Effect Plus Protocol) to efficiently provide mirror therapy for patients with facial palsy. Previous studies demonstrated that the first version of the MEPP website improved user experience and likely optimized patients’ performance during facial therapy. Nevertheless, compliance was found to be low despite a generally positive opinion of the website, and in light of our earlier findings, MEPP 2.0—a revised and enhanced version of the MEPP 0.1—was created. The purpose of this study was to examine and contrast various factors that help or impede institutional partners of the Quebec health care system from using the MEPP 2.0 website in comparison to its initial version.
Methods: Forty-one patients with facial palsyand nineteen clinicians working with this population were enrolled in a within-subject crossover study. For both the MEPP 1.0 and MEPP 2.0, user experience was assessed for all participants. Embodiment was assessed in patients, and factors influencing clinical use were assessed by clinicians. Qualitative comments about their experiences were also gathered. Descriptive statistics and reliability measures were calculated. Differences between the two MEPP versions were assessed using the linear mixed model.
Results: Overall, patients appreciated more the MEPP 2.0 (OR = 4.57; p < 0.001), and all clinicians preferred the MEPP 2.0 over the MEPP 1.0. For patients, it seems that facial ownership, as well as possession and control of facial movements, was significantly better with the MEPP 2.0. For clinicians, the MEPP 2.0 specifically allowed them to self-evaluate their intervention and follow up with more objectivity. The use of the MEPP 2.0 was also modulated by what their patients reported. Qualitatively, options to access an Android app and needs for improving the exercises bank were mentioned as hindering factors.
Conclusions: The updated version of the MEPP website, the MEPP 2.0, was preferred by our different partners.
Trial registration:
https://www.isrctn.com/ISRCTN10885397
The trial was registered before the start of the study on the 1st December 2023
Generative Language Reconstruction from Brain Recordings
Authors: Ye Ziyi , Ai Qingyao , Liu Yiqun , de Rijke Maarten , Zhang Min , Lioma Christina , Ruotsalo Tuukka 
Published: August 2024

Abstract

Language reconstruction from non-invasive brain recordings has been a long-standing challenge. Existing research has addressed this challenge with a classification setup, where a set of language candidates are pre-constructed and then matched with the representation decoded from brain recordings. Here, we propose a new method that addresses language reconstruction through auto-regressive generation, which directly uses the representation decoded from functional magnetic resonance imaging (fMRI) as the input for a large language model (LLM), removing the reliance on the accuracy of pre-constructed candidates. While an LLM can already generate high-quality content, our approach produces results more closely aligned with the visual or auditory language stimuli in response to which brain recordings are sampled, especially for content deemed “surprising” for the LLM. Furthermore, we show that the proposed approach can be used in an auto-regressive manner to reconstruct a 10-minute-long stimulus, which outperforms previous methods with a classification setup. Our findings demonstrate the effectiveness of employing brain language interfaces in a generative setup and delineate a promising path to investigating language formation in the human brain.
USP21-EGFR signaling axis is functionally implicated in metastatic colorectal cancer
Authors: LEE Ki-Young , Shin Ji Hye , Kim Mi-Jeong , Kim Ji Young , Choi Bongkum , Kang Yeeun , Kim Seo Hyun , Lee Ha-Jeong , Kwan Dohee , Cho Yong Beom , Kim Kyeong Kyu , Chun Eunyoung 
Published: August 2024

Abstract

The emerging significance of ubiquitin-specific peptidase 21 (USP21) in stabilizing Fra-1 (FOSL1) has shed light on their involvement in promoting colorectal cancer (CRC) metastasis. Additionally, EGFR signaling has been linked reciprocally with Fra-1 activation in an MMP-dependent manner. However, the functional implications of the USP21-EGFR signaling axis in metastatic CRC (mCRC) remain incompletely understood. RNA-Seq data from tumor tissues (n = 27) and matched normal tissues (n = 27) from 27 mCRC patients were analyzed to investigate the clinical correlation between USP21 and EGFR expression. Functional studies including CRISPR/Cas9 gene editing method to generate USP21-knockout (USP21-KO) CRC cells, in vitro cancer progression and tumor formation assays, in vivo xenograft assays in NSG mice, and therapeutic assays with the USP21 inhibitor, BAY-805, were conducted. Elevated levels of USP21 and EGFR expression in mCRC patients correlated with poorer survival outcomes. Mechanistically, USP21 was found to enhance EGFR stability by deubiquitinating EGFR, resulting in reduced EGFR levels in USP21-KO colon cancer cells. USP21-KO colon cancer cells exhibited significantly attenuated cell proliferation, migration, colony formation, and 3D tumor spheroid formation in response to EGF. Furthermore, tumorigenic activity in vivo was notably diminished in NSG mice xenografted with USP21-KO colon cancer cells. Notably, the USP21 inhibitor, BAY-805, demonstrated a remarkable inhibitory effect on the formation of 3D tumor spheroids in colorectal cancer cells stimulated with EGF. These findings provide valuable insights into the potential of USP21 as both a therapeutic target and a predictive biomarker for intervening in mCRC induced by EGF.
Prehospital management and outcomes of patients calling with chest pain as the main complaint
Authors: Ahmed Sughra , Gnesin Filip , Christensen Helle Collatz , Blomberg Stig Nikolaj , Folke Fredrik , Kragholm Kristian , Bøggild Henrik , Lippert Freddy , Torp-Pedersen Christian , Møller Amalie Lykkemark 
Published: August 2024

Abstract

Background
Chest pain is a frequent cause of health care contacts. We examined the prehospital management, in-hospital discharge diagnoses, and mortality of patients calling a non-emergency and emergency medical service with chest pain.
Methods
We included all calls to a non-emergency medical helpline (calls to 1813) and emergency medical service (1-1-2 calls) with a primary complaint of chest pain from 2014–2018 in Copenhagen, Denmark. The outcomes were: emergency response (ambulance dispatch, other transports/self-transport/home visits, self-care, and unknown/cancelled response), in-hospital diagnosis within 7 days after the call (cardiovascular, pulmonary, or other non-cardiovascular/pulmonary) and 30-day mortality.
Results
Among 4,838,232 calls, 91,671 were registered with chest pain by medical dispatchers. The first call for each patient was kept for analysis (n = 66,672). In total, 91.4% were referred to the hospital, 75.8% (n = 50,627) received an ambulance and 15.6% (n = 10,383) received other transport/self-transport/home visits. In total, 26.9% (n = 17,937) were diagnosed with a cardiovascular disease (Acute Coronary Syndrome (ACS): 11.1%), 5.2% (n = 3,490) a pulmonary disease, 52.8% (n = 35.242) other non-cardiovascular/pulmonary disease, and 15.1% (n = 10,093) received no diagnosis. Among ambulance-transported patients, the prevalence of cardiovascular discharge diagnoses was higher (32.1%) and fewer received no diagnosis (11.0%). Cardiovascular disease was rare among patients not transported by ambulance and patients who were not referred to hospital at all (2-13.4%) and in patients ≤ 40 years of age (< 10%). The 30-day mortality was low regardless of the diagnosis (0.6-4%), and 65,704 were still alive 30 days later.
Conclusion
Nearly all patients calling with chest pain were referred to treatment and among ambulance-transported patients, one-third received a cardiovascular diagnosis. While current practices appear reasonable, improved differentiation of chest pain in telephone consultations could potentially reduce burden of non-acute chest pain consultations.
High vanA Conservation in Vancomycin-Resistant Enterococcus faecalis, Enterococcus faecium, and Staphylococcus aureus: Case Insights
Authors: Kaur Arshmeet 
Published: August 2024

Abstract

Healthcare-associated, vancomycin-resistant Enterococci and Staphylococcus aureus have become increasingly concerning to public health. Previous research onvanA-type vancomycin resistance has focused on characterizing isolates and identifying evolutionarily conserved motifs within the vanA gene to discover potential drug targets. This study is the first in the literature to compare the vanA gene across Enterococcus faecium, Enterococcus faecalis, and Staphylococcus aureus. We analyze data from two patients, collected seven years apart, each experiencing distinct healthcare conditions. The first is a urinary tract infection patient in long-term care in 2004. The second is a liver transplant patient who developed a vancomycin-resistant Enterococci (VRE) infection post-transplant in 2011. We leverage BLAST analysis to examine the genetic diversity and conservation of the vanA gene across strains of all three species from both patients. Additionally, we confirm findings of previous studies conducted independently on each patient.
Analysis of the Oncogenic Role of Methyltransferase Like 3 (METLL3) in Head and Neck Squamous Cell Carcinoma (HNSCC)
Authors: Wang Han , Huang Yinzhu , Piao Yan , Xuan Qingya , Li Xianying , Han Zhezhu , Jin Chengri 
Published: August 2024

Abstract

Purpose
This study focused on the role of methyltransferase-like 3 (METLL3) in head and neck squamous cell carcinoma (HNSCC), analysing its regulatory function in cancer progression, and its feasibility as a potential biomarker and therapeutic target.
Methods
We performed Gene expression, Survival prognosis, Genetic alteration, Immune infiltration, and METTL3-related gene enrichment analysis of METTL3 gene in HNSCC through TIMER2.0 and GEPIA2 databases.
Results
We found that METTL3 expression was significantly higher in HNSCC tumour tissues compared to that in adjacent normal tissues and was associated with poorer disease-free survival, indicating a 50% increased risk of recurrence in patients with high expression. Genetic alteration analysis revealed a low frequency of METTL3 mutations, primarily missense mutations, in HNSCC, suggesting a complex relationship between METTL3expression and the biological characteristics of the tumour. Additionally, the expression of METTL3 was closely related to immune cell infiltration, particularly CD8+ T-cell infiltration, which is especially significant in the immune environment of HNSCC.
Conclusion
These findings not only confirm METTL3's critical role in the pathogenesis of HNSCC but also highlight its potential as a therapeutic target, providing a scientific basis for the development of treatment strategies targeting METTL3, which may help improve treatment outcomes for HNSCC patients.
Use of Computer Vision Analysis for Labeling Inattention Periods in Eeg Recordings With Visual Stimuli
Authors: Isaev Dmitry , Major Samantha , Carpenter Kimberly L.H. , Grapel Jordan , Chang Zhuoqing , Martino Matias Di , Carlson David , Dawson Geraldine , Sapiro Guillermo 
Published: August 2024

Abstract

Electroencephalography (EEG) recordings with visual stimuli require detailed coding to determine the periods of participant’s attention. Here we propose to use a supervised machine learning model and off-the-shelf video cameras only. We extract computer vision-based features such as head pose, gaze, and face landmarks from the video of the participant, and train the machine learning model (multi-layer perceptron) on an initial dataset, then adapt it with a small subset of data from a new participant. Using a sample size of 23 autistic children, and training on additional 2560 labeled frames (equivalent to 85.3 seconds of the video) of a new participant, the median area under the receiver operating characteristic curve for inattention detection was 0.989 (IQR 0.984–0.993) and the median inter-rater reliability (Cohen’s kappa) with a trained human annotator was 0.888. Agreement with consensus annotation on four participants labeled independently by two human annotators was in the 0.827–0.960 range. Our results demonstrate the feasibility of automatic tools to detect inattention during EEG recordings, and its potential to reduce the subjectivity and time burden of human attention coding. The tool for model adaptation and visualization of the computer vision features is made publicly available to the research community.
CD56neg CD16+ cells represent a distinct mature NK cell subset with altered phenotype and are associated with adverse clinical outcome upon expansion in AML.
Authors: Chretien Anne-Sophie , Wlosik Julia , Orlanducci Florence , Richaud Manon , Demerle Clemence , Amara Amira Ben , Rouviere Marie-Sarah , Livrati Philippe , Gorvel Laurent , Hospital Marie Anne , Dulphy Nicolas , Devillier Raynier , Vey Norbert , Olive Daniel 
Published: August 2024

Abstract

CD56neg CD16+ Natural Killer (NK) cells have been reported to expand in chronic diseases and acute myeloid leukemia (AML). However, their biological role is still unclear. Using mass cytometry, spectral flow cytometry, bulk RNA-seq and in vitro assays, we characterized CD56neg CD16+ NK cells that expand in AML. We confirmed that CD56neg CD16+ NK cells represent a unique NK cell subset coexpressing Eomes and T-bet. CD56neg CD16+ NK cells could recover CD56 expression in vitro where they displayed unaltered NK cell functions. We previously demonstrated that CD56neg CD16+ NK cells expansion at diagnosis was associated with adverse clinical outcome in AML. Here, we validated our findings in a validation cohort of N=38 AML patients. AML patients with CD56neg CD16+ NK cells expansion at diagnosis had decreased overall survival (HR[CI95]=5.5[1.2-24.5], p=0.0251) and relapse-free survival (HR[CI95]=13.1[1.9-87.5], p=0.0079) compared to AML patients without expansion after 36 months follow-up. RNA-seq unveiled that CD56neg CD16+ NK cells were mature circulating NK cells with functional capacities. Upon expansion, CD56neg CD16+ NK cells from AML patients showed altered proteomic phenotype, with high expression of TIM-3 and Siglec-7. Taken together, our results suggest that CD56neg CD16+ NK cells are a relevant target for future NK-cell-based immunotherapies.