bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing immune factors in maternal milk and paired infant plasma antibody binding to human rhinoviruses
Authors: Vera Jessica M. , McIlwain Sean J. , Fye Samantha , Palmenberg Ann , Bochkov Yury A. , Li Hanying , Pinapati Richard , Tan John C. , Gern James E. , Seroogy Christine M. , Ong Irene M. 
Published: July 2024

IntroductionBefore they can produce their own antibodies, newborns are protected from infections by transplacental transfer of maternal IgG antibodies and after birth through breast milk IgA antibodies. Rhinovirus (RV) infections are extremely common in early childhood, and while RV infections often result in only mild upper respiratory illnesses, they can also cause severe lower respiratory illnesses such as bronchiolitis and pneumonia.MethodsWe used high-density peptide arrays to profile infant and maternal antibody reactivity to capsid and full proteome sequences of three human RVs - A16, B52, and C11.ResultsNumerous plasma IgG and breast milk IgA RV epitopes were identified that localized to regions of the RV capsid surface and interior, and also to several non-structural proteins. While most epitopes were bound by both IgG and IgA, there were several instances where isotype-specific and RV-specific binding were observed. We also profiled 62 unique RV-C protein loop sequences characteristic of this species’ capsid VP1 protein.DiscussionMany of the RV-C loop sequences were highly bound by IgG from one-year-old infants, indicating recent or ongoing active infections, or alternatively, a level of cross-reactivity among homologous RV-C sites.
Barriers to care linkage and educational impact on unnecessary MASLD referrals
Authors: Lee Jun-Hyuk , Yoon Eileen Laurel , Oh Ju Hyun , Kim Kyunam , Ahn Sang Bong , Jun Dae Won 
Published: July 2024

BackgroundThe importance of primary care physicians (PCPs) in managing metabolic dysfunction-associated steatotic liver disease (MASLD) has increased. This study aimed to assess the effectiveness of an online educational program on MASLD among physicians.MethodsIn total, 869 physicians (72 physicians at referral centers and 797 PCPs) participated in this study. They completed an initial survey regarding their clinical practices for patients with MASLD, followed by a second online survey 8 weeks after receiving a series of seven weekly sets of educational materials on MASLD.ResultsIn the baseline survey, most PCPs did not routinely evaluate the stage of hepatic fibrosis in MASLD; they typically initiated assessments based on elevated liver enzyme levels. Only a limited number of PCPs used vibration-controlled transient elastography. The main hurdles in managing MASLD were “the absence of a fee for patient education” for PCPs and “short consultation time” for referral-center physicians. In the follow-up survey, the percentage of liver fibrosis assessments using noninvasive tests increased from 7.0 to 11.2%. Additionally, evaluations for cardiovascular disease increased from 3.9 to 8.2%, and the risk of ischemic stroke increased from 13.7 to 16.9%. The percentage of immediate referrals of patients to specialists after an MASLD diagnosis decreased from 15.4 to 12.3%.ConclusionThe discrepancies in management strategies and viewpoints regarding MASLD between PCPs and referral-center physicians can hinder efforts to mitigate the disease burden. Increasing awareness among PCPs regarding MASLD through a 7-week education program led to a reduction in unnecessary referral rates and an increase in cardiovascular evaluations.
Promotion of tumor angiogenesis and growth induced by low-dose antineoplastic agents via bone-marrow-derived cells in tumor tissues
Authors: You Huining , Zhao Peipei , Zhao Xue , Zheng Qiaowei , Ma Wenbing , Cheng Kai , Li Min , Kou Jianrong , Feng Weiyi 
Published: July 2024

BackgroundMore research is needed to solidify the basis for reasonable metronomic chemotherapy regimens due to the inconsistent clinical outcomes from studies on metronomic chemotherapy with antineoplastic agents, along with signs of a nonlinear dose–response relationship at low doses. The present study therefore explored the dose–response relationships of representative antineoplastic agents in low dose ranges and their underlying mechanisms.MethodsCyclophosphamide (CPA) and 5-fluorouracil (5-Fu) were employed to observe the effects of the frequent administration of low-dose antineoplastic agents on tumor growth, tumor angiogenesis, and bone-marrow-derived cell (BMDC) mobilization in mouse models. The effects of antineoplastic agents on tumor and endothelial cell functions with or without BMDCs were analyzed in vitro.ResultsTumor growth and metastasis were significantly promoted after the administration of CPA or 5-Fu at certain low dose ranges, and were accompanied by enhanced tumor angiogenesis and proangiogenic factor expression in tumor tissues, increased proangiogenic BMDC release in the circulating blood, and augmented proangiogenic BMDC retention in tumor tissues. Low concentrations of CPA or 5-Fu were found to significantly promote tumor cell migration and invasion, and enhance BMDC adhesion to endothelial cells in vitro.ConclusionThese results suggest that there are risks in empirical metronomic chemotherapy using low-dose antineoplastic agents and the optimal dosage and administration schedule of antineoplastic agents need to be determined through further research.
An advanced three-dimensional phenotypic measurement approach for extracting Ginkgo root structural parameters based on terrestrial laser scanning
Authors: Liang Yinyin , Zhou Kai , Cao Lin 
Published: July 2024

The phenotyping of plant roots is essential for improving plant productivity and adaptation. However, traditional techniques for assembling root phenotyping information are limited and often labor-intensive, especially for woody plants. In this study, an advanced approach called accurate and detailed quantitative structure model-based (AdQSM-based) root phenotypic measurement (ARPM) was developed to automatically extract phenotypes from Ginkgo tree root systems. The approach involves three-dimensional (3D) reconstruction of the point cloud obtained from terrestrial laser scanning (TLS) to extract key phenotypic parameters, including root diameter (RD), length, surface area, and volume. To evaluate the proposed method, two approaches [minimum spanning tree (MST)-based and triangulated irregular network (TIN)-based] were used to reconstruct the Ginkgo root systems from point clouds, and the number of lateral roots along with RD were extracted and compared with traditional methods. The results indicated that the RD extracted directly from point clouds [coefficient of determination (R2) = 0.99, root-mean-square error (RMSE) = 0.41 cm] outperformed the results of 3D models (MST-based: R2 = 0.71, RMSE = 2.20 cm; TIN-based: R2 = 0.54, RMSE = 2.80 cm). Additionally, the MST-based model (F1 = 0.81) outperformed the TIN-based model (F1 = 0.80) in detecting the number of first-order and second-order lateral roots. Each phenotyping trait fluctuated with a different cloud parameter (CP), and the CP value of 0.002 (r = 0.94, p &lt; 0.01) was found to be advantageous for better extraction of structural phenotypes. This study has helped with the extraction and quantitative analysis of root phenotypes and enhanced our understanding of the relationship between architectural parameters and corresponding physiological functions of tree roots.
Investigating suicidal behavior among prisoners in the light of the behavioral addiction approach: results of a multicenter cross-sectional study
Authors: Horváthné Pató Irina , Kresznerits Szilvia , Szekeres Tamás , Zinner-Gérecz Ágnes , Perczel-Forintos Dóra 
Published: July 2024

IntroductionThe behavioral addiction model posits that repetitive suicidal behaviors can serve as maladaptive strategies for managing stress and negative emotional states, akin to substance addiction. Both behaviors involve negative emotions, offer temporary psychological relief, and persist, indicating shared neurobiological mechanisms. This study explored psychometric differences among major repeaters, occasional attempters, and non-suicidal prisoners.MethodsA multi-centre cross-sectional survey of 363 inmates across four prisons assessed depression, cognitive-emotional regulation, impulsivity, perceived stress, lifetime non-suicidal self-injury and suicide attempts.ResultsMild depression, moderate suicidal ideation, and moderate impulsivity were common, with nearly half of the participants having attempted suicide at least once. Hierarchical multiple regression analyses revealed that repeated suicidal behavior in the past increases susceptibility to future suicidal thoughts, with suicide attempts serving as a maladaptive emotion regulation strategy among repeated attempters.DiscussionThe results reveal differences in emotional dysregulation, impulsivity, and stress coping strategies among the studied groups, reinforcing the idea of suicidality as a form of behavioral addiction. The addiction approach helps explain the sensitivity to later suicidal thoughts in former attempters and self-harmers, offering valuable insights for tailored interventions within correctional settings.
The potential of RFID technology for tracking Mangalica pigs in the extensive farming system–a research from Hungary
Authors: Alexy Marta , Pai Rohit Rameshkumar , Ferenci Tamas , Haidegger Tamas 
Published: July 2024

ContextIn recent years, the focus on sustainable meat production in large-scale pig farming has increased. An essential element is acquiring and evaluating digital data on ecological, outdoor pig housing environments and individuals.ObjectiveSome of the precision farming Internet of Things (IoT) tools that can be used in pasture-based, extensive pig production include those that have been proven in pasture-based ruminants and have been used in confined pig production for many years. These include Radio Frequency IDentification (RFID) technology, in which passive RFID tags attached to pigs’ ears capture signals from a reader equipped with an antenna. The reader can also be used to collect weather parameters.MethodsIn our on-farm research, which lasted 7 months and covered three seasons, we used RFID technology to investigate the effects of ambient temperature, humidity, air pressure, and hour of day on the appearance of breeding sows kept on pasture at the wallowing site.Results and conclusionWe found that all three weather parameters and hour-of-day had a significant effect (p &lt; 0.001) on the appearance of sows at the wallow. We calculated the THI (Temperature Humidity Index) and found days in summer and early autumn when there was a risk of heat stress. This is essential information for the pig farmer because heat stress has a strong negative effect on sow fertility. Our on-farm study found that RFID technology is suitable for detecting the presence of pigs in the pasture. However, the limitations of the technology, both in terms of the housing environment and the species specificity of the pigs, need to be taken into account.SignificanceIn pasture-based pig production systems, the meat production process is performed under extensive conditions of natural animal-environment interaction. The negative impact on the natural environment is much lower, but animal welfare is higher than in intensive pig farming. It is also a profit-oriented activity, where the production of traceable and reliable animal products is a social and economic requirement. Collecting information from trusted sources using precision livestock farming (PLF) techniques is also feasible in this type of farming, providing significant added value for pig farmers and consumers.
The Utility of the Vasoactive-Inotropic Score and Its Nomogram in Guiding Postoperative Management in Heart Transplant Recipients
Authors: Xiong Tixiusi , Yim Wai Yen , Chi Jiangyang , Wang Yixuan , Lan Hongwen , Zhang Jing , Sun Yongfeng , Shi Jiawei , Chen Si , Dong Nianguo 
Published: July 2024

BackgroundIn the early postoperative stage after heart transplantation, there is a lack of predictive tools to guide postoperative management. Whether the vasoactive-inotropic score (VIS) can aid this prediction is not well illustrated.MethodsIn total, 325 adult patients who underwent heart transplantation at our center between January 2015 and December 2018 were included. The maximum VIS (VISmax) within 24 h postoperatively was calculated. The Kaplan-Meier method was used for survival analysis. A logistic regression model was established to determine independent risk factors and to develop a nomogram for a composite severe adverse outcome combining early mortality and morbidity.ResultsVISmax was significantly associated with extensive early outcomes such as early death, renal injury, cardiac reoperation and mechanical circulatory support in a grade-dependent manner, and also predicted 90-day and 1-year survival (p &lt; 0.05). A VIS-based nomogram for the severe adverse outcome was developed that included VISmax, preoperative advanced heart failure treatment, hemoglobin and serum creatinine. The nomogram was well calibrated (Hosmer-Lemeshow p = 0.424) with moderate to strong discrimination (C-index = 0.745) and good clinical utility.ConclusionVISmax is a valuable prognostic index in heart transplantation. In the early post-transplant stage, this VIS-based nomogram can easily aid intensive care clinicians in inferring recipient status and guiding postoperative management.
Interaction between Trichoderma sp., Pseudomonas putida, and Two Organic Amendments on the Yield and Quality of Strawberries (Fragaria x annanasa cv. San Andreas) in the Huaral Region, Peru
Authors: Huasasquiche Lucero , Ccori Thania , Alejandro Leonela , Cántaro-Segura Héctor , Samaniego Tomás , Solórzano Richard 
Published: July 2024

Strawberry cultivation holds significant economic and social promise within Peruvian fruit production. However, conventional management practices have led to the excessive use of agrochemicals in this crop. This study proposes an organic approach to strawberry production, integrating less environmentally harmful technologies. The aim was to assess microbial inoculation by using Trichoderma sp. and Pseudomonas putida and the application of organic amendments on strawberry seedlings of the commercial cultivar “San Andreas”. A field experiment was established with evaluations in the vegetative and productive stages. Results indicate that the co-inoculation of Trichoderma sp. and Pseudomonas putida increased leaf area by 7%, and enhanced the aerial part’s fresh and dry biomass by 13% and 28%, respectively, compared to treatment without microbial inoculation. Concurrently, compost application increased the leaf number and aerial dry biomass by 22% and 19% at the end of the vegetative stage, respectively, compared to treatment without organic amendment. In addition, it reduced the days for flowering, maintaining the fruit’s physicochemical attributes. Regarding yield, the amendments application significantly enhanced fruit weight per plant by 40%, especially when applied together with Trichoderma sp., and co-inoculation increased the number of fruits per meter square by 22%. These findings highlight the potential of technologies such as microbial inoculation and organic amendments to enhance strawberry yields and to gradually reduce the use of synthetic fertilizers.
Dry Powder Inhaler Formulation of Lactobacillus rhamnosus GG Targeting Pseudomonas aeruginosa Infection in Bronchiectasis Maintenance Therapy
Authors: Tran The-Thien , Cheow Wean Sin , Pu Siyu , Park Jin-Won , Hadinoto Kunn 
Published: July 2024

The inhaled delivery of lactic acid bacteria (LAB) probiotics has been demonstrated to exert therapeutic benefits to the lungs due to LAB’s immunomodulatory activities. The development of inhaled probiotics formulation, however, is in its nascent stage limited to nebulized LAB. We developed a dry powder inhaler (DPI) formulation of lactobacillus rhamnosus GG (LGG) intended for bronchiectasis maintenance therapy by spray freeze drying (SFD). The optimal DPI formulation (i.e., LGG: mannitol: lactose: leucine = 35: 45: 15: 5 wt.%) was determined based on the aerosolization efficiency (86% emitted dose and 26% respirable fraction) and LGG cell viability post-SFD (7 log CFU/mL per mg powder). The optimal DPI formulation was evaluated and compared to lyophilized naked LGG by its (1) adhesion capacity and cytotoxicity to human lung epithelium cells (i.e., A549 and 16HBE14o- cells) as well as its (2) effectiveness in inhibiting the growth and adhesion of Pseudomonas aeruginosa to lung cells. The optimal DPI of LGG exhibited similar non-cytotoxicity and adhesion capacity to lung cells to naked LGG. The DPI of LGG also inhibited the growth and adhesion of P. aeruginosa to the lung cells as effectively as the naked LGG. The present work established the feasibility of delivering the LAB probiotic by the DPI platform without adversely affecting LGG’s anti-pseudomonal activities.
Pharmacotherapy and Stone Mineral Subtype Influence Long-Term Recurrence Rates in Calcium Stone Formers
Authors: Ruchi Rupam , Di Valerio Elizabeth A. , Bozorgmehri Shahab , Bacchus Michael Waseer , Canales Benjamin K. , Terry Russell , DiBianco John Michael , Bird Vincent G. 
Published: July 2024

Key Points

Long-term recurrence data on pure metabolic calcium stone formers are limited.The presented data highlight the importance of medical therapy in preventing future stones among high-risk patients.Our study shows that the benefit of medical therapy may take 5 years to be evident; this fact should be considered in planning future studies.

Background
Long-term recurrence data on kidney stones are limited. We investigated stone recurrence in calcium-oxalate (CaOx) and calcium-phosphate (CaP) stone formers over a 10- to 12-year follow-up period.

Methods
We retrospectively identified patients from a surgical database with (1) CaOx or CaP stones, (2) postsurgical computed tomography imaging, and (3) at least 10 years of clinical follow-up and imaging. Data on medical therapy (MT), defined as being on thiazide/thiazide-like diuretic, potassium citrate, and/or allopurinol, were collected. Patients' records were reviewed for stone recurrence over a 10- to 12-year period. Associations between stone type, MT, and time to recurrence were analyzed with Kaplan–Meier survival curves and Cox proportional hazard models. Multivariate analysis was done using the Cox proportional hazard model.

Results
Of the 149 individuals who met inclusion criteria, 87 (58.3%) underwent baseline 24-hour urine testing, and 46 (30.8%) were prescribed MT in the form of thiazide (26/46; 57%), potassium citrate (25/46; 54%), and allopurinol (5/46; 11%). Compared with non-MT patients, patients on MT were more likely to have diagnosis of hypertension (P = 0.008) and be hypocitraturic at baseline (P = 0.01). Over a mean of 10.6 years, patients on MT had significantly fewer stone events compared with those not on MT (21.3% versus 37.5%, P = 0.04), with 8 (17%) individuals discontinuing their MT over the study period. Patients with predominantly CaP mineral subtype had more stone events than CaOx (64% versus 36%, P = 0.006), a phenomenon likely driven by higher baseline urine pH (>6, 58.8% versus 33.9%, P = 0.02). By survival analysis, the impact of stone subtype and MT became apparent at follow-up months 20 and 60, respectively.

Conclusions
In a population of calcium stone formers at high recurrence risk, patients with CaOx mineral subtype and on MT had the lowest stone event rate on long-term follow-up. These findings suggest that the beneficial effect of MT may take up to 5 years to become evident clinically and by surveillance imaging.
Strengthening the Social Orientation of Tax Systems
Authors: Трофимова Я.В. 
Published: July 2024

Автор статьи предлагает рассматривать налоговые изменения в рамках рыночной социальной политики государства. В работе отмечаются противоречия в ее осуществлении, а также новые формы и приемы в налоговых приоритетах.The author of the article proposes to consider tax changes in the market social policy of the state. The paper notes contradictions in its implementation, as well as new forms and techniques in tax priorities.
Evaluation of the Efficiency of Business Processes of the Geological Exploration Division of Oil Companies
Authors: Халикова М.А. , Чиглинцев Д.С. 
Published: July 2024

В статье рассматриваются вопросы оценки эффективности бизнес-процессов подразделения «Геологоразведка» вертикально-интегрированных нефтяных компаний (ВИНК). Предлагается авторский подход к формированию алгоритма оценки эффективности бизнес-процессов подразделения «Геологоразведка», обеспечивающего построение оптимальной бизнес-модели подразделения.
The article discusses the issues of assessing the effectiveness of business processes of the Geological Exploration Division of vertically integrated oil companies. The author's approach to the formation of an algorithm for assessing the effectiveness of business processes of the Geological Exploration subdivision is proposed, which ensures the construction of an optimal business model for the subdivision
Forecasting the Financial Targets of an Oil Company in a Turbulent Economy
Authors: Халикова Э.А. , Гизатуллина Э.Э. 
Published: July 2024

Научная статья посвящена анализу выбора известных эконометрических моделей прогнозирования, наиболее полно отражающих нерегулярность и хаотичность изменения финансово-экономических индикаторов, и являющихся более чувствительными к последним изменениям. Авторами статьи обоснована необходимость применения модели Брауна ввиду ее адаптивности и высокой чувствительности к последним изменениям в турбулентной экономике. В качестве апробации в статье рассмотрено влияние двух макроэкономических индикаторов – цены на нефть марки Urals и курса доллара по отношению к рублю – на изменение дохода от продажи нефти на примере одной из ведущих нефтяных компаний. По результатам выявленной зависимости представлен прогнозный план целевых финансовых показателей на период до 2030 года.
The scientific article is devoted to the analysis of the choice of well-known econometric forecasting models that most fully reflect the irregularity and chaos of changes in financial and economic indicators, and are more sensitive to recent changes. The authors of the article substantiated the need to apply Brown's model in view of its adaptability to recent changes in a turbulent economy and being more sensitive to recent changes. As an approbation, the article examines the influence of two macroeconomic indicators - the price of Urals oil and the dollar exchange rate against the ruble - on the change in income from oil sales using the example of one of the leading oil companies. Based on the results of the revealed dependence, a forecast plan of target financial indicators for the period up to 2030 is presented.