bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severely high serum unbound bilirubin level after abdominal surgery in a newborn
Authors: Morioka Ichiro , Miwa Akihiro , Yokota Tomoyuki , Huu Chuong Thieu Do , Nagasaka Miwako , Koda Tsubasa , Matsuo Kiyomi , Morikawa Satoru , Shibata Akio , Hisamatsu Chieko , Nishio Hisahide , Yamada Hideto , Nishijima Eiji , Iijima Kazumoto 
Published: June 2013

AbstractWe report a newborn with intestinal malrotation who developed a severely high serum unbound bilirubin level and a low serum albumin level without a marked increase in serum total bilirubin level after abdominal surgery, which required exchange transfusion and albumin supplementation. The serum unbound bilirubin level may be highly relative to the serum total bilirubin level in newborns who have undergone abdominal surgery soon after birth and are hypoalbuminemic after surgery.
Pneumatic pyloric dilatation for the treatment of gastric outlet obstruction in a child
Authors: Gobbi Dalia , Billi Paola , Fascetti Leon Francesco , Alvisi Patrizia , Lambertini Andrea , Lima Mario 
Published: June 2013

AbstractAcquired causes of gastric outlet obstruction (GOO) are rarely encountered in infancy, having an approximate incidence of 1 per 100 000 live births. Reports of short‐term exposure to non‐steroidal anti‐inflammatory drugs having adverse events are few. We present the case of a previously healthy 3‐year‐old boy who developed severe chronic gastric outlet obstruction and antral stenosis after a short‐term ingestion of liquid ibuprofen at a dosage not thought to be associated with unfavorable effects. Even though the optimal management of these cases remains to be determined, we report on a prompt and successful endoscopic treatment for this condition.
Treatment with oseltamivir and prone positioning for a 9‐year‐old boy with ARDS caused by pandemic H1N1 2009 influenza
Authors: Suyama Kazuhide , Kawasaki Yukihiko , Suzuki Yuichi , Ishii Kiyoko , Sakai Nobuko , Sato Masatoki , Hashimoto Kohichi , Hosoya Mitsuaki 
Published: June 2013

AbstractHere we report the case of a 9‐year‐old boy with acute respiratory distress syndrome (ARDS) caused by novel H1N1 swine‐origin influenza virus A. A diagnosis of ARDS caused by a novel influenza A (H1N1) virus was made on the basis of chest X‐ray and computed tomography together with low oxygenation index (OI) and the detection of novel influenza A (H1N1) virus from tracheal secretion samples. Oseltamivir phosphate and prone positioning were effective in the treatment of ARDS in this case. These findings suggest that anti‐viral drugs and prone positioning can play an important role in the improvement of ARDS caused by novel H1N1 swine‐origin influenza virus A.
A simple approach to define Holocene sequence stratigraphy using borehole and cone penetration test data
Authors: Styllas Michael 
Published: June 2013

AbstractCone penetration testing has been widely used since the 1950s for determining the subsurface geotechnical conditions of unconsolidated sediments. This paper highlights the potential value of cone penetration testing as an aid to define the stratigraphic structure of Holocene sedimentary deposits. By calibrating cone penetration test logs with adjacent borehole logs and by utilizing all the available information produced during geotechnical surveying, stratigraphic models that accurately describe the vertical and lateral boundaries, as well as the stacking pattern, of Late Quaternary systems can be constructed. The widespread application and technical simplicity of cone penetration testing, combined with simple data interpretation via correlation with adjacent borehole logs, yield a useful and inexpensive tool for sedimentological investigations. This methodology is illustrated using data from 36 cone penetration tests and 11 boreholes on the Holocene deltaic plain of the Aliakmon River, Greece. Sedimentological and stratigraphic information from core log correlations, the spatial distribution of cone penetration test parameters, sediment grain size and per cent concentration of organic matter are utilized. The results suggest, that in sequence stratigraphic terms, the delta is divided into a lowstand systems tract composed by fluvial gravels and sands (U0) of Late Pleistocene age, as well as from red oxidized clays, and a transgressive systems tract represented by fluvial channel sands (U1), overlain by a thin transgressive sand sheet of coastal origin (U2), characterized by fining upward trends. The highstand systems tract is constituted by a variety of stratigraphic units (U3 to U7) and depositional environments, characterized by coarsening upward sequences, representing both aggradational and progradational facies, and dominated by the presence of three prograding wedges. Detailed definition of the thickness, vertical boundaries and stacking pattern of the resolved stratigraphic units, presented as a two‐dimensional stratigraphic model, demonstrates the applicability of the proposed method.
Klebsiella necrotizing soft tissue infections in liver transplant recipients: a case series
Authors: Rana M.M. , Sturdevant M. , Patel G. , Huprikar S. 
Published: June 2013

AbstractNecrotizing soft tissue infections (NSTI) are rare but carry high mortality rates. NSTI with Klebsiella species have been previously described as associated with Klebsiella liver abscesses and endophthalmitis. Here, we describe 6 cases of NSTI in liver transplant recipients associated with Klebsiella pneumoniae, 4 of which were K. pneumoniae carbapenemase (KPC)‐producing K. pneumoniae (CRKP). Increased awareness of this emerging pathogen and its association with necrotizing skin and soft tissue infection is critical, as early recognition and debridement may improve survival. Antimicrobial treatment of CRKP infections remains an ongoing challenge and implementation of enhanced infection control measures is essential.
Feline sarcoptic mange in Taiwan: a case series of five cats
Authors: Huang Hui‐Pi , Lien Yu‐Hsin 
Published: June 2013

BackgroundSarcoptes scabiei infestation is rare in cats.ObjectiveTo report the clinical presentations and treatments of cats infested with S. scabiei.AnimalsFive cats that presented with progressive and nonresponsive crusting lesions on the concave and convex aspects of the pinnae are included in this series. Other dermatological manifestations recorded were crusts on the bridge of the nose (five of five), crusty pododermatitis (three of five), crusty lesions on the tail (one of five) and pruritic erythematous papules on the arms and/or thighs of the owners (five of five). None of the cats was living in a household with a dog.MethodsSarcoptic (S. scabiei) mange was diagnosed based on the identification of S. scabiei in deep skin scrapings. A spot‐on application of 1.0% moxidectin and 10% imidacloprid (0.1 mL/kg) was administered every 2 weeks for three applications. All cats were re‐evaluated at the time of treatment.ResultsAll five cats and their owners improved after the first application and reached clinical remission after the third application. Deep skin scrapings from all cats were negative for S. scabiei after the first application. No clinical adverse effects or abnormalities on routine blood tests were noted during the study period. No reinfestation was reported during the follow‐up period of 6 months after treatment.ConclusionAlthough sarcoptic mange is rare in cats, it should be considered as a differential diagnosis for cats presenting with crusting lesions on the pinnae and nose and crusty pododermatitis. A spot‐on preparation of moxidectin and imidacloprid was used successfully to treat cats with S. scabiei infestation.
Change of stand structure in upper tree line caused by disturbances
Authors: Gubka K. , Pittner J. 
Published: June 2013

In 2002, the series of 4 permanent research plots of different altitudes (difference 100 m) was established in forest stand that is the part of upper tree line. In the plots we registered the quantitative and qualitative biometric characteristics of individual trees. The results showed that the stand is relatively statically stable (sufficient parameters of crown ratio and slenderness). The studied stand had adequate density and the number of stems was increasing with the decreasing altitude (from 1,460 to 1,260 m a.s.l.). The stand was comparable with the model one (yield tables) regarding the quantitative as well as qualitative parameters.After the wind disturbance in 2004, two studied plots in higher altitudes were totally destroyed. In the time of repeated measurements (in 2010) the negative impact of the bark-beetle outbreak began to be visible. It was reflected in increased mortality of spruce also in the research plots situated in lower altitudes of studied stand. We confirmed that the neglect of forest hygiene and adequate silvicultural treatment leads to decline of stand condition and functionality in the upper tree line forests.
Wave Based Method for Free Vibration Analysis of Cylindrical Shells
With Nonuniform Stiffener Distribution
Authors: Wei Jianhui , Chen Meixia , Hou Guoxiang , Xie Kun , Deng Naiqi 
Published: June 2013

Abstract
Wave based method (WBM) is presented to analysis the free vibration characteristics of cylindrical shells with nonuniform stiffener distributions for arbitrary boundary conditions. The stiffeners are treated as discrete elements. The equations of motion of annular circular plate are used to describe the motion of stiffeners. Instead of expanding the dynamic field variables in terms of polynomial approximation in element based method (finite element method etc), the ring-stiffened cylindrical shell is divided into several substructures and the dynamic field variables in each substructure are expressed as wave function expansions. Boundary conditions and continuity conditions between adjacent substructures are used to form the final matrix to be solved. Natural frequencies of cylindrical shells with uniform rings spacing and eccentricity distributions for shear diaphragm-shear diaphragm boundary conditions have been calculated by WBM model which shows good agreement with the experimental results and the analytical results of other researchers. Natural frequencies of cylindrical shells with other boundary conditions have also been calculated and the results are compared with the finite element method which also shows good agreement. Effects of the nonuniform rings spacing and nonuniform eccentricity and effects of boundary conditions on the fundamental frequencies and the beam mode frequencies have been studied. Different stiffener distributions are needed to increase the fundamental frequencies and beam mode frequencies for different boundary conditions. WBM model presented in this paper can be recognized as a semianalytical and seminumerical method which is quite useful in analyzing the vibration characteristics of cylindrical shells with nonuniform rings spacing and eccentricity distributions.
JADA: A graphical user interface for comprehensive internal dose assessment in nuclear medicine
Authors: Grimes Joshua , Uribe Carlos , Celler Anna 
Published: June 2013

Purpose:The main objective of this work was to design a comprehensive dosimetry package that would keep all aspects of internal dose calculation within the framework of a single software environment and that would be applicable for a variety of dose calculation approaches.Methods:Our MATLAB‐based graphical user interface (GUI) can be used for processing data obtained using pure planar, pure SPECT, or hybrid planar/SPECT imaging. Time‐activity data for source regions are obtained using a set of tools that allow the user to reconstruct SPECT images, load images, coregister a series of planar images, and to perform two‐dimensional and three‐dimensional image segmentation. Curve fits are applied to the acquired time‐activity data to construct time‐activity curves, which are then integrated to obtain time‐integrated activity coefficients. Subsequently, dose estimates are made using one of three methods.Results:Theorgan level dose calculation subGUI calculates mean organ doses that are equivalent to dose assessment performed by OLINDA/EXM. Voxelized dose calculation options, which include the voxel S value approach and Monte Carlo simulation using the EGSnrc user code DOSXYZnrc, are available within the process 3D image data subGUI.Conclusions:The developed internal dosimetry software package provides an assortment of tools for every step in the dose calculation process, eliminating the need for manual data transfer between programs. This saves times and minimizes user errors, while offering a versatility that can be used to efficiently perform patient‐specific internal dose calculations in a variety of clinical situations.
Sarcoidosis of the pancreas mimicking adenocarcinoma
Authors: Mayne Alistair Ivan William , Ahmad Jawad , Loughrey Maurice , Taylor Mark A 
Published: June 2013

Primary sarcoidosis of the pancreas is extremely rare. Clinical presentation is often identical to that of pancreatic adenocarcinoma. Preoperative diagnosis of primary pancreatic sarcoidosis is always challenging. We present a 52-year-old man who developed weight loss and obstructive jaundice. Abdomino-pelvic CT scan showed a mass in the pancreatic head. After hepatopancreaticobiliary MDT discussion, a Whipple's procedure was attempted but the mass was deemed unresectable due to invasion of the superior mesenteric vein. Upon completion of palliative chemotherapy, repeat imaging showed significant mass shrinkage. A reattempt Whipple's procedure was successfully undertaken. Histology showed changes of chronic pancreatitis and peripancreatic granulomatous inflammation with no evidence of malignancy and a diagnosis of sarcoidosis was made. Owing to the devastating nature of pancreatic adenocarcinoma, any mass in the pancreas must be thoroughly investigated before a definitive diagnosis is made.
Shortening, structural relief and drainage evolution in inverted rifts: insights from the Atlas Mountains, the Eastern Cordillera of Colombia and the Pyrenees
Authors: Babault Julien , Teixell Antonio , Struth Lucía , Van Den Driessche Jean , Arboleya María Luisa , Tesón Eliseo 
Published: June 2013

Abstract

The Atlas, Eastern Cordillera and Pyrenees are thick-skinned thrust-fold belts formed by tectonic inversion of rift basins in continental settings. A comparison of shortening between them shows a gradation from 20–25% in the central High Atlas, to 25–30% in the Eastern Cordillera, and
c.
40% in the Pyrenees. Accordingly, there is a structural variation from interior zones with low structural relief and isolated basement massifs in the first two cases, to an axial culmination of stacked basement thrust sheets in the Pyrenees. This results in marked topographic and drainage variation: the High Atlas and Eastern Cordillera contain axial plateaus dominated by structure-controlled longitudinal rivers and orogen flanks with slope-controlled transverse rivers, whereas the Pyrenees show a two-sided wedge profile dominated by transverse rivers. In spite of singularities exhibited by each orogen, we propose that this spatial variation can be understood as reflecting different degrees of evolution in mountain building. Rapidly incising, transverse rivers are capturing earlier longitudinal streams of the Atlas and Eastern Cordillera, thus reducing their axial plateaux, which will eventually disappear into a transverse-dominated drainage. This pattern of landscape evolution may be characteristic of inversion orogens as they develop from initial stages of inversion to full accretion.
Basin compartmentalization and drainage evolution during rift inversion: evidence from the Eastern Cordillera of Colombia
Authors: Silva A. , Mora A. , Caballero V. , Rodriguez G. , Ruiz C. , Moreno N. , Parra M. , Ramirez-Arias J. C. , Ibáñez M. , Quintero I. 
Published: June 2013

Abstract
The Cenozoic stratigraphic infill of hinterland and foreland basins in central Colombia holds the record of basin development during tectonic inversion of rift in the context of subduction orogenesis. A comprehensive review of detrital U–Pb geochronologic and thermochronologic data reveals that activation of interconnected fault systems in the hinterland Magdalena Valley and the Eastern Cordillera occurred coevally since Paleocene time. Longitudinal basins were fed by detritus shed from the Central Cordillera carried along axial drainage systems in open basins in times where slow deformation rates prevailed. Faster deformation since Oligocene resulted in the transient formation of internally drained basins. Differential along-strike exhumation and subsidence patterns in the Eastern Cordillera and the foredeep, respectively, document tectonic acceleration since late Miocene, which we attribute to superimposed collision of the Panama arc leading to oroclinal bending in the Cordillera. Our data documents that the inherited structural grain led to the formation of longitudinal drainage patterns, even in closed basins, which seem to be a general feature of early stages of inversion. We hypothesize that the presence of more humid climatic conditions and faster tectonic rates along the range’s eastern margin favoured the development of internally drained basins, as has also been shown in the Central Andes.

Supplementary material:

Methods details (zircon grains preparation, zircon U–Pb measurements, laboratory conditions and input constraints for AFT thermal modelling) and repository are available at
http://www.geolsoc.org.uk/SUP18628
RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation
Authors: Mirschberger Christian , Schiller Christian B. , Schräml Michael , Dimoudis Nikolaos , Friess Thomas , Gerdes Christian A. , Reiff Ulrike , Lifke Valeria , Hoelzlwimmer Gabriele , Kolm Irene , Hopfner Karl-Peter , Niederfellner Gerhard , Bossenmaier Birgit 
Published: June 2013

Abstract
The EGF receptor (EGFR) HER3 is emerging as an attractive cancer therapeutic target due to its central position in the HER receptor signaling network. HER3 amplifies phosphoinositide 3-kinase (PI3K)–driven tumorigenesis and its upregulation in response to other anti-HER therapies has been implicated in resistance to them. Here, we report the development and characterization of RG7116, a novel anti-HER3 monoclonal antibody (mAb) designed to block HER3 activation, downregulate HER3, and mediate enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) via glycoengineering of the Fc moiety. Biochemical studies and X-ray crystallography revealed that RG7116 bound potently and selectively to domain 1 of human HER3. Heregulin binding was prevented by RG7116 at concentrations more than 1 nmol/L as was nearly complete inhibition of HER3 heterodimerization and phosphorylation, thereby preventing downstream AKT phosphorylation. In vivo RG7116 treatment inhibited xenograft tumor growth up to 90% relative to controls in a manner accompanied by downregulation of cell surface HER3. RG7116 efficacy was further enhanced in combination with anti-EGFR (RG7160) or anti-HER2 (pertuzumab) mAbs. Furthermore, the ADCC potency of RG7116 was enhanced compared with the nonglycoengineered parental antibody, both in vitro and in orthotopic tumor xenograft models, where an increased median survival was documented. ADCC degree achieved in vitro correlated with HER3 expression levels on tumor cells. In summary, the combination of strong signaling inhibition and enhanced ADCC capability rendered RG7116 a highly potent HER3-targeting agent suitable for clinical development. Cancer Res; 73(16); 5183–94. ©2013 AACR.
The Association of High-Density Lipoprotein Cholesterol with Cancer Incidence in Type II Diabetes: A Case of Reverse Causality?
Authors: Morton Jamie , Ng Martin K.C. , Chalmers John , Woodward Mark , Mancia Giuseppe , Poulter Neil R. , Marre Michel , Cooper Mark E. , Zoungas Sophia ,   for the ADVANCE collaborative group
Published: June 2013

Abstract
Background: Low high-density lipoprotein cholesterol (HDL-C) and type II diabetes are associated with an increased risk for cancer. Patients with type II diabetes typically have low HDL-C; however, the association between HDL-C and cancer has not been examined in this population.
Methods: A total of 11,140 patients with type II diabetes were followed for a median of 5 years. Cox proportional hazard models were used to assess the association between baseline HDL-C and risk of cancer incidence and cancer death, with adjustments made for potential confounders. To explore the possibility of reverse causation, analyses were repeated for the cancers occurring in the first and second halves of follow-up.
Results: Six hundred and ninety-nine patients developed cancer, with 48% occurring within the first half of follow-up. For every 0.4 mmol/L lower baseline HDL-C, there was a 16% higher risk of cancer [HR 1.16; 95% confidence interval (CI), 1.06–1.28; P = 0.0008] and cancer death (HR 1.16; 95% CI, 1.01–1.32; P = 0.03). After adjustment for confounding, the higher risk remained significant for cancer (adjusted HR 1.10; 95% CI, 1.00–1.22; P = 0.05) but not for cancer death (adjusted HR 1.08; 95% CI, 0.93–1.25; P = 0.31). The association was driven by cancers occurring within the first half of follow-up (adjusted HR 1.22; 95% CI, 1.05–1.41; P = 0.008) as no significant association was found between HDL-C and cancer in the second half of follow-up.
Conclusions: Low HDL-C is associated with cancer risk in patients with type II diabetes. However, this association may be explained by confounding and reverse causation.
Impact: HDL-C is not a risk factor for cancer in type II diabetes. Cancer Epidemiol Biomarkers Prev; 22(9); 1628–33. ©2013 AACR.
Serum Proteoglycans as Prognostic Biomarkers of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis
Authors: Nault Jean-Charles , Guyot Erwan , Laguillier Christelle , Chevret Sylvie , Ganne-Carrie Nathalie , N'Kontchou Gisèle , Beaugrand Michel , Seror Olivier , Trinchet Jean-Claude , Coelho Jessica , Lasalle Philippe , Charnaux Nathalie , Delehedde Maryse , Sutton Angela , Nahon Pierre 
Published: June 2013

Abstract
Background: Proteoglycans are involved in neoangiogenesis and transduction of oncogenic signals, two hallmarks of carcinogenesis.
Methods: This study sought to assess the prognostic value of serum levels of three proteoglycans (endocan, syndecan-1, and glypican-3) and VEGF in 295 patients with alcoholic cirrhosis: 170 without hepatocellular carcinoma, 58 with early hepatocellular carcinoma, and 67 with advanced hepatocellular carcinoma at inclusion. We analyzed the association between proteoglycan levels and prognosis using Kaplan–Meier and Cox methods.
Results: Serum levels of the three proteoglycans and VEGF were increased in patients with advanced hepatocellular carcinoma compared with those without hepatocellular carcinoma or with early hepatocellular carcinoma. In multivariate analysis, high levels of serum endocan (&gt;5 ng/mL) were independently associated with death [HR, 2.84; 95% confidence interval (CI,) 1.18–6.84; P = 0.02], but not with hepatocellular carcinoma occurrence, in patients without hepatocellular carcinoma at baseline. High serum endocan (&gt;5 ng/mL) and syndecan-1 (&gt;50 ng/mL) levels were significantly associated with greater risk of tumor recurrence (P = 0.025) in patients with early hepatocellular carcinoma treated by radiofrequency ablation. In patients with advanced hepatocellular carcinoma, high serum levels of endocan (P = 0.004) and syndecan-1 (P = 0.006) were significantly associated with less favorable overall survival. However, only a high level of serum syndecan-1 (&gt;50 ng/mL) was independently associated with greater risk of death (HR, 6.21 95% CI, 1.90–20.30; P = 0.0025).
Conclusion: Serum endocan and syndecan-1 are easily assessable prognostic serum biomarkers of overall survival in alcoholic cirrhosis with and without hepatocellular carcinoma.
Impact: These new biomarkers will be useful to manage patients with hepatocellular carcinoma developed on alcoholic cirrhosis. Cancer Epidemiol Biomarkers Prev; 22(8); 1343–52. ©2013 AACR.