bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Discovery of N‐(4‐Methoxy‐7‐methylbenzo[d]thiazol‐2‐yl)isonicatinamide, ML293, as a Novel, Selective and Brain Penetrant Positive Allosteric Modulator of the Muscarinic 4 (M4) Receptor.
Authors: Hopkins Corey R. , et al. et al. 
Published: November 2012

AbstractTitle compound (I) represents a novel muscarinic 4 (M4) receptor tool with superior in vivo PK properties compared to previously published molecules.
Patient perspectives on breast cancer treatment plan and summary documents in community oncology care
Authors: Blinder Victoria S. , Norris Virginia W. , Peacock Nancy W. , Griggs Jennifer J. , Harrington David P. , Moore Anne , Theriault Richard L. , Partridge Ann H. ,   on behalf of the American Society of Clinical Oncology Breast Cancer Registry Pilot Steering Group
Published: November 2012

AbstractBACKGROUND:Although the routine use of treatment plans and summaries (TPSs) has been recommended to improve the quality of cancer care, limited data exist about their impact on quality, including patient satisfaction and coordination of care.METHODS:Patients received TPSs as part of the American Society of Clinical Oncology Breast Cancer Registry (BCR) pilot program of 20 community oncology practices. Participants were surveyed 2 to 4 weeks after receiving a TPS to evaluate their perceptions of the document. Patients who were receiving chemotherapy received the TPS as separate plan and summary documents (at the start and the end of treatment) and could complete 2 surveys. Others received a single integrated TPS. Eligible survey participants had stage 0 through III breast cancer and were enrolled in the BCR.RESULTS:Of 292 consented patients, 174 (60%) completed at least 1 survey. Of 157 patients who recalled receiving a TPS, 148 (94%) believed that the documents improved patient‐physician communication, and 128 (82%) believed that they improved communication between physicians; 113 (72%) said the documents increased their peace of mind, whereas 2 (1%) had less peace of mind. Of 152 patients (97%) who still had their documents, 147 (97%) said they were useful, and 94 (62%) had given or planned to give the documents to another physician. All 63 patients who were surveyed after receiving a summary recommended that practices continue to provide TPSs to patients.CONCLUSIONS:Participants in this study expressed high satisfaction with TPSs. Additional research is needed to study the broad‐scale implementation of the BCR and to evaluate the impact of routine use of TPSs on the quality of care delivered. Cancer 2013. © 2012 American Cancer Society.
Face memory deficits in patients deprived of early visual input by bilateral congenital cataracts
Authors: de Heering Adélaïde , Maurer Daphne 
Published: November 2012

AbstractPatients treated for bilateral congenital cataract are later impaired on several hallmarks of adults' expertise with upright faces but report no problem with remembering faces. Here, we provide the first formal data on their face memory. We compared 12 adults with a history of visual deprivation from bilateral congenital cataracts to 24 age‐matched controls with normal vision on their ability to recognize famous and recently learned faces, and on their subjective impression of their face memory. Bilateral congenital cataract patients demonstrated a prosopagnosic‐like deficit, being slower and less accurate in recognizing both famous faces and recently learned faces, despite not differing on most questions about their impression of their face memory. Patients' results on three perceptual tasks (the composite face effect, the Benton test of recognizing faces through a change in point of view, and the Jane test of sensitivity to feature spacing) were also not correlated with their face memory deficits. These results suggest that early visual input is necessary not only for perceptual expertise in differentiating among unfamiliar upright faces, but also for normal accuracy in remembering the identity of individual faces. © 2012 Wiley Periodicals, Inc. Dev Psychobiol 56: 96–108, 2014.
Spatial genetic analysis reveals high connectivity of tiger (Panthera tigris) populations in the Satpura–Maikal landscape of Central India
Authors: Sharma Sandeep , Dutta Trishna , Maldonado Jesús E. , Wood Thomas C. , Panwar Hemendra Singh , Seidensticker John 
Published: November 2012

AbstractWe investigated the spatial genetic structure of the tiger meta‐population in the Satpura–Maikal landscape of central India using population‐ and individual‐based genetic clustering methods on multilocus genotypic data from 273 individuals. The Satpura–Maikal landscape is classified as a global‐priority Tiger Conservation Landscape (TCL) due to its potential for providing sufficient habitat that will allow the long‐term persistence of tigers. We found that the tiger meta‐population in the Satpura–Maikal landscape has high genetic variation and very low genetic subdivision. Individual‐based Bayesian clustering algorithms reveal two highly admixed genetic populations. We attribute this to forest connectivity and high gene flow in this landscape. However, deforestation, road widening, and mining may sever this connectivity, impede gene exchange, and further exacerbate the genetic division of tigers in central India.
Influence of oil phase concentration on droplet size distribution and stability of oil‐in‐water emulsions
Authors: Dapčević Hadnađev Tamara , Dokić Petar , Krstonošić Veljko , Hadnađev Miroslav 
Published: November 2012

AbstractThe objective of this study was to investigate the effect of oil phase concentration, at different emulsification conditions concerning homogenization time and emulsifier content, on droplet size distribution and stability of corn oil‐in‐water emulsions. Emulsions were prepared with 3, 5, 10, and 20% w/w triethanolamine oleate (calculated on oil amount), 0.53% w/w carboxymethylcellulose (calculated on water amount), and 5, 10, 20, 30, or 40% w/w oil, and homogenized 5, 10, 20, and 60 min. It was found that increase in oil phase concentration led to decrease in specific surface area and increase in polydispersity of emulsion at lower emulsifier concentration and less intense homogenization. At emulsifier concentrations ≤10% and homogenization time ranges of 20–60 min the non‐monotonous variation in droplet size parameters with oil concentration was observed, as a result of the interaction between triethanolamine oleate and carboxymethylcellulose, which were confirmed by viscosity measurements. However, at emulsifier concentration of 20% an increase in specific surface area and decrease in polydispersity with the increase in oil concentration occurred due to an increase in equilibrium concentration of emulsifier in the continuous phase. Further, influence of oil concentration on emulsion creaming stability was found to be independent on emulsifier concentration and homogenization time. Therefore, a decrease in creaming with increase in oil concentration was observed in all the examined triethanolamine oleate (TEAO) concentration and homogenization time ranges.Practical applications: Emulsions are colloidal systems which can be encountered in different industrial sectors, such as food, pharmaceutical, cosmetics, oil industry, etc. Determination of the droplet size of emulsion is probably the most important way of their characterization, since it influences the properties of emulsion such as rheology, texture, shelf life stability, appearance, taste, etc. The size of the droplets depends on a wide range of parameters. One of them is certainly the concentration of the oil phase. However, since the impact of one parameter is often influenced with the intensity of the other variable involved in the emulsion generation, the aim of the present work was to examine the effect of corn oil concentration on droplet size parameters and stability of oil‐in‐water emulsions at different emulsification conditions. Therefore a step toward creation of emulsions with desired final properties was made.
Are we ready to use oxidative stress in clinical practice?
Authors: Grabowski Marcin 
Published: November 2012

AbstractSee accompanying article http://dx.doi.org/10.1002/ejlt.201200107The relationship between atherosclerosis, intravascular inflammation, and oxidative stress has fascinated scientists and clinicians for a long time and is still the subject of continuing research. The hypothesis is very attractive, both from the pathophysiological and therapeutic point of view and has perspective for new therapeutic strategies.
Stereodivergent Total Synthesis of (+)‐Aspergillide B and (+)‐7‐epi‐Aspergillide A
Authors: Sridhar Y. , Srihari P. 
Published: November 2012

AbstractThe stereoselective total syntheses of (+)‐aspergillide B and (+)‐7‐epi‐aspergillide A were achieved. The key reactions include Noyori's asymmetric transfer hydrogenation, an Achmatowicz rearrangement, a Ferrier‐type alkynylation, a hydrosilylation–protodesilylation, a CBS (Corey–Bakshi–Shibata) oxazaborolidine reduction, a Yamaguchi macrolactonization, and a Mitsunobu macrolactonization.
Synthesis of Planar Chiral N‐Heterocyclic‐Substituted Pyridinophanes
Authors: Kramer Joshua J. P. , Nieger Martin , Bräse Stefan 
Published: November 2012

AbstractFour new planar chiral N‐heterocyclic‐substituted [2](1,4)benzene[2](2,5)pyridinophanes have been synthesized. With the attached pyrazole, triazole, tetrazole, and pyrimidine moieties, different N,N‐chelating ligands that vary in the number of enclosed nitrogen atoms, ring size, and electronic properties were added to a mostly neglected class of pyridinophanes. Additionally, the known synthesis of the pyridinophane scaffold was simplified considerably. With the acetyl, amino, and amido pyridinophane, various useful intermediates for new pyridinophane ligands were synthesized, which would allow for further investigations of this ligand system.
Simultaneous Determination of Zn(II), Cu(II), Cd(II) and Pb(II) in Soil Samples Employing an Array of Potentiometric Sensors and an Artificial Neural Network Model
Authors: Wilson Deivy , Gutiérrez Juan Manuel , Alegret Salvador , del Valle Manel 
Published: November 2012

AbstractA sensor array of 9 potentiometric PVC sensors has been employed for the simultaneous determination of heavy metals in soil. Sensors were firstly characterized in their response: Nernstian behavior, a concentration range from ca. 10−6 to 10−2 M and selectivity coefficients confirming that all sensors had cross‐response for the target ions. The mixed response system was modeled employing Artificial Neural Networks. The proposed tool was applied to the determination of Pb2+, Cd2+, Cu2+ and Zn2+ in soils at the mg kg−1 level with satisfactory performance. Results were compared and validated against AAS reference methodology, with correlations R2>0.948 for the four heavy metals considered.
Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults
Authors: Yang Yisheng , Chang Benny Hung‐Junn , Chan Lawrence 
Published: November 2012

AbstractGenome‐wide association studies identified GLIS3 as a susceptibility locus for type 1 and type 2 diabetes. Global Glis3 deficiency in mice leads to congenital diabetes and neonatal lethality. In this study, we explore the role of Glis3 in adulthood using Glis3+/− and conditional knockout animals. We challenged Glis3+/− mice with high fat diet for 20 weeks and found that they developed diabetes because of impaired beta cell mass expansion. GLIS3 controls beta cell proliferation in response to high‐fat feeding at least partly by regulating Ccnd2 transcription. To determine if sustained Glis3 expression is essential to normal beta cell function, we generated Glis3fl/fl/Pdx1CreERT+ animal by intercrossing Glis3fl/fl mice with Pdx1CreERT+ mice and used tamoxifen (TAM) to induce Glis3 deletion in adults. Adult Glis3fl/fl/Pdx1CreERT+ mice are euglycaemic. TAM‐mediated beta cell‐specific inactivation of Glis3 in adult mice downregulates insulin expression, leading to hyperglycaemia and subsequently enhanced beta cell apoptosis. We conclude that normal Glis3 expression is required for pancreatic beta cell function and mass maintenance during adulthood, which impairment leads to diabetes in adults.
Review of odorants in human axillary odour and laundry malodour: The importance of branched C7 chain analogues in malodours perceived by humans
Authors: Takeuchi Kohei , Yabuki Masayuki , Hasegawa Yoshihiro 
Published: November 2012

ABSTRACTIn our daily lives we are confronted with various kinds of malodour problems. Detailed analysis at the molecular level of the malodorous constituents with gas chromatography–mass spectrometry and gas chromatography–olfactometry can be used to identify the key chemicals responsible for the malodours, and such information can provide novel starting points for the development of new deodorants. This paper describes two characteristic sources of malodour in daily life: axillary and laundry malodour. Detailed analytical studies identified specific major contributors to these malodours: 3‐hydroxy‐3‐methylhexanoic acid, 3‐mercapto‐3‐methylhexan‐1‐ol and 4‐methyl‐3‐hexenoic acid. Biochemical and microbiological studies then elucidated the mechanisms generating these odours and proved the involvement of microbes in odour formation. In this review, we discuss the importance of the branched C7 chain, which is common to all the major volatile substances identified in these studies and perceived by the human nose with an extraordinary sensitivity. Copyright © 2012 John Wiley & Sons, Ltd.
Cognitive mechanisms of memory for order in rhesus monkeys (Macaca mulatta)
Authors: Templer Victoria L. , Hampton Robert R. 
Published: November 2012

AbstractOne important aspect of episodic memory is the ability to remember the order in which events occurred. Memory for sequences in rats and has been shown to rely on the hippocampus and medial prefrontal cortex (DeVito and Eichenbaum (2011) J Neuro 31:3169‐3175; Fortin et al. (2002) Nat Neuro 5:458‐462). Rats with hippocampal lesions were impaired in selecting the odor that had appeared earlier in a sequence of five odors but were not impaired in recognition of previously sampled odors (Fortin et al., 2002; Kesner et al. (2002) Behav Neuro 116:286‐290). These results suggest that order is not represented by relative familiarity or memory strength. However, the cognitive mechanisms underlying memory for order have not been determined. We presented monkeys with lists of five images drawn randomly from a pool of 6,000 images. At test, two images were presented and monkeys were rewarded for selecting the image that had appeared earlier in the studied list. Monkeys learned to discriminate the order of the images, even those that were consecutive in the studied list. In subsequent experiments, we found that discrimination of order was not controlled by list position or relative memory strength. Instead, monkeys used temporal order, a mechanism that appears to encode order of occurrence relative to other events, rather than in absolute time. We found that number of intervening images, rather than passage of time per se, most strongly determined the discriminability of order of occurrence. Better specifying the cognitive mechanisms nonhuman primates use to remember the order of events enhances this animal model of episodic memory, and may further inform our understanding of the functions of the hippocampus. © 2012 Wiley Periodicals, Inc.
An evaluation of the hydrologic relevance of lateral flow in snow at hillslope and catchment scales
Authors: Eiriksson David , Whitson Michael , Luce Charles H. , Marshall Hans Peter , Bradford John , Benner Shawn G. , Black Thomas , Hetrick Hank , McNamara James P. 
Published: November 2012

AbstractLateral downslope flow in snow during snowmelt and rain‐on‐snow (ROS) events is a well‐known phenomenon, yet its relevance to water redistribution at hillslope and catchment scales is not well understood. We used dye tracers, geophysical methods, and hydrometric measurements to describe the snow properties that promote lateral flow, assess the relative velocities of lateral flow in snow and soil, and estimate volumes of downslope flow. Results demonstrate that rain and melt water can travel tens of metres downslope along layers within the snowpack or at the snowpack base within tens of hours. Lateral flow within the snowpack becomes less likely as the snowpack becomes saturated and stratigraphic boundaries are destroyed. Flow along the base can be prevalent in all snowpack conditions. The net result of lateral flow in snow can be the deposition of water on the soil surface in advanced downslope positions relative to its point of origin, or direct discharge to a stream. Although both melt and ROS events can redistribute water to downslope positions, ROS events produced the most significant volumes of downslope flow. Direct stream contributions through the snowpack during one ROS event produced up to 12% of streamflow during the event. This can help explain rapid delivery of water to streams during ROS events, as well as anomalously high contributions of event water during snowmelt hydrographs. In catchments with a persistent snowpack, lateral redistribution of water within the snowpack should be considered a relevant moisture redistribution mechanism. Copyright © 2012 John Wiley & Sons, Ltd.
Integrating toxicity reduction strategies for materials and components into product design: A case study on utility meters
Authors: Lam Carl W , Lim Seong-Rin , Ogunseitan Oladele A , Shapiro Andrew A , Saphores Jean-Daniel M , Brock Andrew , Schoenung Julie M 
Published: November 2012

Abstract
Using RIO Tronics utility meter products as an industrial case study, the numeric Fraunhofer Toxic Potential Indicator (TPI) assessment tool is used to determine high impact materials with the aim of reducing the content of inherently toxic substances in these products. However, because product redesign with alternative materials affects entire components, overall component toxicity potential must also be explored. To achieve this, material TPI scores are aggregated into component TPI scores by 2 methods: 1) the Sum-Weighted Component TPI method, which considers the mass of materials in the component to assign an overall score, and 2) the Max Component TPI method, which scores the component with the highest impact material. With consideration of uncertainties from materials' toxicity information and mass estimates, key results from both scoring methods prioritized components that contain acrylonitrile-based polymers, polyvinyl chloride (PVC), and stainless steel. Furthermore, an alternative materials assessment is carried out to identify less-toxic substitutes to meet cost and technical constraints. Substitute materials such as Al alloys for stainless steel and high-density polyethylene for PVC show promise for a combination of toxicity reduction and cost-effectiveness. The new screening methodology described can help product designers systematically benchmark toxicity potential in parallel to cost and functionality. Integr Environ Assess Manag 2013; 9: 319–328. © 2012 SETAC
Monitoring LITT thermal penetration depth using real‐time analysis of backscattered light
Authors: Shacham Ranit , Steinberg Idan , Gandjbakhche Amir H. , Gannot Israel 
Published: November 2012

AbstractReal‐time monitoring of the thermal penetration depth (TPD) is essential in various clinical procedures, such as Laser Interstitial Thermal Therapy (LITT). MRI is commonly used to this end, though bulky and expensive. In this paper, we present an alternative novel method for an optical feedback system based on changes in the diffused reflection from the tissue during treatment. Monte‐Carlo simulation was used to deduce the relations between the backscattered pattern and the TPD. Several methods of image analysis are developed for TPD estimation. Each yields a set of parameters which are linearly dependent on the TPD. In order to test these experimentally, tissue samples were monitored in‐vitro during treatment at multiple wavelengths. The SNR and coefficient of determination were used to compare the various methods and wavelengths and to determine the preferred method. Such system and algorithms may be used for real‐time in‐vivo control during laser thermotherapy and other clinical procedures. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Feature‐based recognition of Surface‐enhanced Raman spectra for biological targets
Authors: Pavillon Nicolas , Bando Kazuki , Fujita Katsumasa , Smith Nicholas I. 
Published: November 2012

AbstractWe propose and compare multiple approaches to automatically process data measured through surface‐enhanced Raman scattering (SERS), in the context of intracellular molecule probing. It relies on locally detecting the most relevant spectra to retrieve all data independently through indexing, thus avoiding any pre‐filtering which occurs with standard processing methods. We first assess our approach on simulated data of the spectrum of Rhodamine 6G, and then validate high‐performing methods on experimental measurements of this compound. The optimized method is then utilized to extract and classify the complex SERS response behavior of gold nanoparticles taken in live cells. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Chemically‐specific dual/differential CARS micro‐spectroscopy of saturated and unsaturated lipid droplets
Authors: Di Napoli Claudia , Masia Francesco , Pope Iestyn , Otto Cees , Langbein Wolfgang , Borri Paola 
Published: November 2012

AbstractWe have investigated the ability of dual‐frequency Coherent Antistokes Raman Scattering (D‐CARS) micro‐spectroscopy, based on femtosecond pulses (100 fs or 5 fs) spectrally focussed by glass dispersion, to distinguish the chemical composition of micron‐sized lipid droplets consisting of different triglycerides types (poly‐unsaturated glyceryl trilinolenate, mono‐unsaturated glyceryl trioleate and saturated glyceryl tricaprylate and glyceryl tristearate) in a rapid and label‐free way. A systematic comparison of Raman spectra with CARS and D‐CARS spectra was used to identify D‐CARS spectral signatures which distinguish the disordered poly‐unsaturated lipids from the more ordered saturated ones both in the CH‐stretch vibration region and in the fingerprint region, without the need for lengthy CARS multiplex acquisition and analysis. D‐CARS images of the lipid droplets at few selected wavenumbers clearly resolved the lipid composition differences, and exemplify the potential of this technique for label‐free chemically selective rapid imaging of cytosolic lipid droplets in living cells. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)