bluuebunny/crossref_metadata_2025_split huggingface dataset:
A brain‐potential correlate of task‐set conflict
Authors: Elchlepp Heike , Rumball Freya , Lavric Aureliu 
Published: January 2013

AbstractBrain‐potential correlates of response conflict are well documented, but those of task conflict are not. Task‐switching studies have suggested a plausible correlate of task conflict—a poststimulus posterior negativity—however, in such paradigms the negativity may also reflect poststimulus task‐set reconfiguration postulated in some models. Here, participants alternated between single‐task blocks of classifying letters and digits; hence, no within‐block task‐set reconfiguration was required. Presenting letters alongside digits slowed responses to the digits and elicited an ERP negativity from ∼350 ms, relative to task‐neutral symbols presented alongside digits, consistent with task conflict. The negativity was also present for congruent digit‐letter stimuli; this and the lack of behavioral response congruency effects indicate conflict at the level of task‐set rather than response selection.
N1pc reversal following repeated eccentric visual stimulation
Authors: Casiraghi Mahesh , Fortier‐Gauthier Ulysse , Sessa Paola , Dell'Acqua Roberto , Jolicœur Pierre 
Published: January 2013

AbstractEarly event‐related potential (ERP) hemispheric asymmetries recorded at occipitoparietal sites are usually observed following the sudden onset of a lateral peripheral stimulus. This is usually reflected in an onset‐locked larger N1 over the posterior contralateral hemisphere relative to the ipsilateral hemisphere, an early ERP asymmetry labeled N1pc. When the peripheral sudden onset is followed by a central stimulus, or by a bilaterally balanced visual array of stimuli, these events evoke a reversed N1pc, that is, a larger N1 over the hemisphere ipsilateral to the peripheral sudden onset. This N1pc reversal has been taken as evidence for a remapping of the visual space from an absolute, retinally based frame of reference to a relative, attentionally based frame of reference that codes the spatial positions of objects relative to the peripheral sudden onset, rather than relative to the fovea. Here, we pit the reference frame‐remapping account against an alternative account based on reduced neural reactivity following the peripheral sudden onset. In three experiments, we varied the spatial location of an object relative to a preceding sudden onset, and tested the opposite predictions generated by the frame‐remapping and the reduced neural reactivity accounts. Taken together, the results from the present experiments were consistent with the reduced neural reactivity account and inconsistent with the frame‐remapping account.
Augmenting soil water storage using uncharred switchgrass and pyrolyzed biochars
Authors: Novak J. M. , Watts D. W. 
Published: January 2013

AbstractBiochar is an amendment that can augment soil water storage; however, its projected cost per ton could be financially limiting at field application scales. It may be more monetarily convenient if an alternate amendment was available that could deliver similar soil enhancements. We compared two switchgrass biochars pyrolyzed at 250 and 500 °C with raw switchgrass (uncharred) on moisture storage and bulk density changes in a Norfolk loamy sand (fine‐loamy, kaolinitic, thermic Typic Kandiudult). Amendments were mixed into triplicate pots at 20 g/kg along with untreated controls. Soils were laboratory incubated at 10% moisture content (w/w) for 118 days, and the pots were irrigated three times with 1.3 pore volumes of deionized water every 30 days. Soil bulk densities were recorded before each irrigation event. Assessment of alterations in soil water storage was examined through cumulative water evaporative losses from incubation day 0 to day 33 and by monitoring soil water contents for 13 consecutive days past each irrigation event. Rankings of soil water evaporative losses were as follows: uncharred switchgrass ≤ switchgrass (500 °C) ≤ switchgrass (250 °C) < control. After the first irrigation event, uncharred switchgrass amendment significantly increased moisture storage compared with soil treated with biochar and the control. While all amendments increased water storage relative to the control, uncharred switchgrass delivered equivalent, if not slightly better, moisture storage improvements compared with the two switchgrass biochars. Uncharred switchgrass would likely not be as effective over the long term (years to decades) as pyrolyzed biochars, due to greater degradation of uncharred material.
Mountain laurel toxicosis in a dog
Authors: Manhart Ingrid O. , DeClementi Camille , Guenther Christine L. 
Published: January 2013

AbstractObjectiveTo describe a case of mountain laurel (Kalmia latifolia) toxicosis in a dog, including case management and successful outcome.Case SummaryA dog presented for vomiting, hematochezia, bradycardia, weakness, and ataxia, which did not improve with supportive treatment. Mountain laurel ingestion was identified as cause of clinical signs after gastrotomy was performed to remove stomach contents. Supportive treatment was continued and the dog made a full recovery.New or Unique Information ProvidedThis report details a case of mountain laurel toxicosis in a dog, including management strategies and outcome, which has not been previously published in the veterinary literature.
Comparison of routine urinalysis and urine Gram stain for detection of bacteriuria in dogs
Authors: Way Leilani Ireland , Sullivan Lauren A. , Johnson Valerie , Morley Paul S. 
Published: January 2013

AbstractObjectiveTo determine the utility of performing urine Gram stain for detection of bacteriuria compared to routine urine sediment examination and bacterial aerobic urine culture.DesignProspective, observational study.SettingUniversity teaching hospital.AnimalsUrine samples acquired via cystocentesis through convenience sampling from 103 dogs presenting to a tertiary referral institution.InterventionsAll samples underwent routine urinalysis, including sediment examination, as well as urine Gram stain and quantitative bacterial aerobic urine culture.Measurements and Main ResultsThe urine Gram stain demonstrated improved sensitivity (96% versus 76%), specificity (100% versus 77%), positive predictive value (100% versus 83%), and negative predictive value (93% versus 69%) when identifying bacteriuria, compared to routine urine sediment examination.ConclusionsThe urine Gram stain is highly sensitive and specific when detecting the presence of bacteria in canine urine samples. Gram staining should be considered when bacteriuria is highly suspected and requires rapid identification while bacterial culture is pending.
Ivermectin‐induced blindness treated with intravenous lipid therapy in a dog
Authors: Epstein Steven E. , Hollingsworth Steven R. 
Published: January 2013

AbstractObjectiveTo report a case of blindness due to the ingestion of ivermectin and subsequent successful treatment with intravenous lipid (IVL) therapy.Case SummaryA female neutered Jack Russell Terrier was examined for acute onset of apparent blindness after being exposed to ivermectin the previous day. The dog appeared to be blind during initial examination. Pupillary light reflex, menace response, and dazzle reflex were not present in either eye. Fundic examination revealed small areas of linear retinal edema. Electroretinography (ERG) showed diminished activity in both eyes. Ivermectin was present in the serum on toxicological assay. Approximately 20 hours after exposure, IVL was infused. Within 30 minutes of initiating the infusion, the pupillary light reflexes returned in both eyes, and by the end of the infusion the patient behaved as if sighted. Fundic examination and ERG were unchanged at this time. The dog was tested for the multidrug resistance gene mutation and was unaffected.New or Unique Information ProvidedIvermectin toxicity occurs in dogs with apparent blindness being a common clinical sign. This is the first case report of ivermectin‐induced blindness evaluated with ERG before and after treatment with IVL in a dog unaffected by the multidrug resistance gene mutation. Treatment with an infusion of IVL therapy appeared to shorten the clinical course of disease in this patient without affecting ERG results.
Autologous canine red blood cell transfusion using cell salvage devices
Authors: Kellett‐Gregory Lindsay M. , Seth Mayank , Adamantos Sophie , Chan Daniel L. 
Published: January 2013

AbstractObjectiveTo describe the use of automated blood salvage devices for autotransfusion in dogs.TechniqueBlood salvage devices can be used to collect blood from the intraoperative surgical field or postsurgical drainage sites. The salvage device washes cells in 0.9% saline, removing plasma proteins, other cellular components, and activators of coagulation and inflammation. Washed red blood cells may be safely returned to the patient, minimizing the need for allogeneic blood transfusions.SignificanceBlood salvage has been safely used in human medicine for decades and is feasible in veterinary medicine. Potential advantages include reduced reliance on banked blood for massive transfusions and minimization of morbidities associated with the use of allogeneic and stored blood products. Concerns about the safety of salvaged blood have been largely dispelled in human medicine but further investigation regarding the safety of such procedures in veterinary patients is warranted.
RECONN: A CYTOSCAPE PLUG-IN FOR EXPLORING AND VISUALIZING REACTOME
Authors: LIGTENBERG WILLEM P.A. , BOŠNAČKI DRAGAN , HILBERS PETER A. J. 
Published: January 2013

Interface and visualization tools usually provide static representations of biological pathways, which can be a severe limitation: fixed pathway boundaries are used without consensus about the elements that should be included in a particular pathway; one cannot generate new pathways or produce selective views of existing pathways. Also, the tools are not capable of integrating multiple levels that conceptually can be distinguished in biological systems. We present ReConn, an interface and visualization tool for a flexible analysis of large data at multiple biological levels. ReConn (Reactome Connector) is an open source extension to Cytoscape which allows user friendly interaction with the Reactome database. ReConn can use both predefined Reactome pathways as well as generate new pathways. A pathway can be derived by starting from any given metabolite and existing pathways can be extended by adding related reactions. The tool can also retrieve alternative routes between elements of a biological network. Such an option is potentially applicable in the design and analysis of knockout experiments. ReConn displays information about multiple levels of the system in one view. With these dynamic features ReConn addresses all of the above mentioned limitations of the interface tools.
The Genomic Landscape of Breast Cancer as a Therapeutic Roadmap
Authors: Ellis Matthew J. , Perou Charles M. 
Published: January 2013

Abstract
Summary: The application of high-throughput techniques to profile DNA, RNA, and protein in breast cancer samples from hundreds of patients has profoundly increased our knowledge of the disease. The etiologic events that drive breast cancer are finally coming into focus and should be used to set priorities for clinical trials. In this Prospective, we summarize some of the headline conclusions from 6 recent breast cancer “omics profiling” articles in Nature, with an emphasis on the implications for systemic therapy. Cancer Discov; 3(1); 27–34. ©2012 AACR.
Mechanisms of Resistance to PARP Inhibitors—Three and Counting
Authors: Fojo Tito , Bates Susan 
Published: January 2013

Abstract
Summary: Given the malleable nature of cancer cells, we should expect, and do see, the development of resistance to any new chemotherapeutic agent. Models that help us understand how this happens are a first step to better and more effective chemotherapeutics. Cancer Discov; 3(1); 20–3. ©2012 AACR.
See related article by Jaspers et al., p. 68
Unpicking the Combination Lock for Mutant BRAF and RAS Melanomas
Authors: Al-Lazikani Bissan , Workman Paul 
Published: January 2013

Abstract
Summary: Large-scale, unbiased combinatorial drug screening has been used to identify effective genotype-selective therapeutic combinations that show promising activity in preclinical models of mutant BRAF andRAS melanoma that are resistant to the clinical BRAF inhibitor vemurafenib. Cancer Discov; 3(1); 14–9. ©2012 AACR.
See related article by Held et al., p. 52
Evaluation of Temperature and Precipitation Trends and Long-Term Persistence in CMIP5 Twentieth-Century Climate Simulations
Authors: Kumar Sanjiv , Merwade Venkatesh , Kinter James L. , Niyogi Dev 
Published: January 2013

Abstract
The authors have analyzed twentieth-century temperature and precipitation trends and long-term persistence from 19 climate models participating in phase 5 of the Coupled Model Intercomparison Project (CMIP5). This study is focused on continental areas (60°S–60°N) during 1930–2004 to ensure higher reliability in the observations. A nonparametric trend detection method is employed, and long-term persistence is quantified using the Hurst coefficient, taken from the hydrology literature. The authors found that the multimodel ensemble–mean global land–average temperature trend (0.07°C decade−1) captures the corresponding observed trend well (0.08°C decade−1). Globally, precipitation trends are distributed (spatially) at about zero in both the models and in the observations. There are large uncertainties in the simulation of regional-/local-scale temperature and precipitation trends. The models’ relative performances are different for temperature and precipitation trends. The models capture the long-term persistence in temperature reasonably well. The areal coverage of observed long-term persistence in precipitation is 60% less (32% of land area) than that of temperature (78%). The models have limited capability to capture the long-term persistence in precipitation. Most climate models underestimate the spatial variability in temperature trends. The multimodel ensemble–average trend generally provides a conservative estimate of local/regional trends. The results of this study are generally not biased by the choice of observation datasets used, including Climatic Research Unit Time Series 3.1; temperature data from Hadley Centre/Climatic Research Unit, version 4; and precipitation data from Global Historical Climatology Network, version 2.
The Asymmetric Influence of the Two Types of El Niño and La Niña on Summer Rainfall over Southeast China
Authors: Karori Muhammad Afzaal , Li Jianping , Jin Fei-Fei 
Published: January 2013

Abstract
In this study, the authors demonstrate that the two types of El Niño–Southern Oscillation (ENSO) have asymmetric features with respect to the impact of their positive and negative phases on boreal summer rainfall over the Yangtze River Valley (YRV) and South China (SC). The relationship between rainfall over the YRV and the warm pool (WP) La Niña is positive and significant, whereas the relationship with the WP El Niño is not. In the case of the cold tongue (CT) ENSO, its positive phase has a positive influence, while there is no significant relationship with the negative phase. In contrast, rainfall over SC has a significant positive relationship with WP El Niño, but a nonsignificant relationship with WP La Niña. The positive phase of the CT ENSO has a significant negative influence on SC rainfall, while the negative phase has a nonsignificant impact. An asymmetric atmospheric response to the asymmetric sea surface temperature anomalies (SSTAs) was also observed in the lower troposphere. The location of the center of the anomalous circulations over the study region differs during the opposite phases of the two types of ENSO. This asymmetric response is likely to be linked to the different spatial patterns of the two types of El Niño and La Niña. Atmospheric general circulation models confirm the authors' analysis of the observed data. Numerical simulations show that the asymmetric response of the lower atmosphere is driven mainly by differing SSTA patterns in the equatorial Pacific Ocean.
Detectability of Changes in the Walker Circulation in Response to Global Warming*
Authors: DiNezio Pedro N. , Vecchi Gabriel A. , Clement Amy C. 
Published: January 2013

Abstract
Changes in the gradients in sea level pressure (SLP) and sea surface temperature (SST) along the equatorial Pacific are analyzed in observations and 101 numerical experiments performed with 37 climate models participating in the fifth phase of the Coupled Model Intercomparison Project (CMIP5). The ensemble of numerical experiments simulates changes in the earth’s climate during the 1870–2004 period in response to changes in natural (solar variations and volcanoes) and anthropogenic (well-mixed greenhouse gases, ozone, direct aerosol forcing, and land use) radiative forcings. A reduction in the zonal SLP gradient is present in observational records and is the typical response of the ensemble, yet only 26 out of the 101 experiments exhibit a reduced SLP gradient within 95% statistical confidence of the observed value. The multimodel response indicates a reduction of the Walker circulation to historical forcings, albeit an order of magnitude smaller than the observed value. There are multiple nonexclusive interpretations of these results: (i) the observed trend may not be entirely forced and includes a substantial component from internal variability; (ii) there are problems with the observational record that lead to a spuriously large trend; and (iii) the strength of the Walker circulation, as measured by the zonal SLP gradient, may be less sensitive to external forcing in models than in the real climate system. Analysis of a subset of experiments suggests that greenhouse gases act to weaken the circulation, but aerosol forcing drives a strengthening of the circulation, which appears to be overestimated by the models, resulting in a muted response to the combined anthropogenic forcings.
The Response of Tropical Atmospheric Energy Budgets to ENSO*
Authors: Mayer Michael , Trenberth Kevin E. , Haimberger Leopold , Fasullo John T. 
Published: January 2013

Abstract
The variability of zonally resolved tropical energy budgets in association with El Niño–Southern Oscillation (ENSO) is investigated. The most recent global atmospheric reanalyses from 1979 to 2011 are employed with removal of apparent discontinuities to obtain best possible temporal homogeneity. The growing length of record allows a more robust analysis of characteristic patterns of variability with cross-correlation, composite, and EOF methods. A quadrupole anomaly pattern is found in the vertically integrated energy divergence associated with ENSO, with centers over the Indian Ocean, the Indo-Pacific warm pool, the eastern equatorial Pacific, and the Atlantic. The smooth transition, particularly of the main maxima of latent and dry static energy divergence, from the western to the eastern Pacific is found to require at least two EOFs to be adequately described. The canonical El Niño pattern (EOF-1) and a transition pattern (EOF-2; referred to as El Niño Modoki by some authors) form remarkably coherent ENSO-related anomaly structures of the tropical energy budget not only over the Pacific but throughout the tropics. As latent and dry static energy divergences show strong mutual cancellation, variability of total energy divergence is smaller and more tightly coupled to local sea surface temperature (SST) anomalies and is mainly related to the ocean heat discharge and recharge during ENSO peak phases. The complexity of the structures throughout the tropics and their evolution during ENSO events along with their interactions with the annual cycle have often not been adequately accounted for; in particular, the El Niño Modoki mode is but part of the overall evolutionary patterns.
Importance of Regional Climate Model Grid Spacing for the Simulation of Heavy Precipitation in the Colorado Headwaters
Authors: Prein Andreas F. , Holland Gregory J. , Rasmussen Roy M. , Done James , Ikeda Kyoko , Clark Martyn P. , Liu Changhai H. 
Published: January 2013

Abstract
Summer and winter daily heavy precipitation events (events above the 97.5th percentile) are analyzed in regional climate simulations with 36-, 12-, and 4-km horizontal grid spacing over the headwaters of the Colorado River. Multiscale evaluations are useful to understand differences across horizontal scales and to evaluate the effects of upscaling finescale processes to coarser-scale features associated with precipitating systems.
Only the 4-km model is able to correctly simulate precipitation totals of heavy summertime events. For winter events, results from the 4- and 12-km grid models are similar and outperform the 36-km simulation. The main advantages of the 4-km simulation are the improved spatial mesoscale patterns of heavy precipitation (below ~100 km). However, the 4-km simulation also slightly improves larger-scale patterns of heavy precipitation.
Separating Cloud and Drizzle Radar Moments during Precipitation Onset Using Doppler Spectra
Authors: Luke Edward P. , Kollias Pavlos 
Published: January 2013

Abstract
The retrieval of cloud, drizzle, and turbulence parameters using radar Doppler spectra is challenged by the convolution of microphysical and dynamical influences and the overall uncertainty introduced by turbulence. A new technique that utilizes recorded radar Doppler spectra from profiling cloud radars is presented here. The technique applies to areas in clouds where drizzle is initially produced by the autoconversion process and is detected by a positive skewness in the radar Doppler spectrum. Using the Gaussian-shape property of cloud Doppler spectra, the cloud-only radar Doppler spectrum is estimated and used to separate the cloud and drizzle contributions. Once separated, the cloud spectral peak can be used to retrieve vertical air motion and eddy dissipation rates, while the drizzle peak can be used to estimate the three radar moments of the drizzle particle size distribution. The technique works for nearly 50% of spectra found near cloud top, with efficacy diminishing to roughly 15% of spectra near cloud base. The approach has been tested on a large dataset collected in the Azores during the Atmospheric Radiation Measurement Program (ARM) Mobile Facility deployment on Graciosa Island from May 2009 through December 2010. Validation of the proposed technique is achieved using the cloud base as a natural boundary between radar Doppler spectra with and without cloud droplets. The retrieval algorithm has the potential to characterize the dynamical and microphysical conditions at cloud scale during the transition from cloud to precipitation. This has significant implications for improving the understanding of drizzle onset in liquid clouds and for improving model parameterization schemes of autoconversion of cloud water into drizzle.