bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Recyclable [bmIm]OH Promoted One‐Pot Heterocyclization: Synthesis of Substituted Benzofurans.
Authors: Siddiqui I. R. , Waseem Malik Abdul , Shamim Shayna , Shireen Shireen , Srivastava Arjita , Srivastava Anjali 
Published: October 2013

AbstractIn this reaction the ionic liquid plays a triple role as a base, solvent, as well as catalyst.
ChemInform Abstract: Concise Synthesis of Arylnaphthalene Lignans by Regioselective Intramolecular Anionic Diels—Alder Reactions of 1,7‐Diaryl‐1,6‐diynes.
Authors: Kudoh Takayuki , Shishido Ai , Ikeda Kyohei , Saito Seiki , Ishikawa Teruhiko 
Published: October 2013

AbstractThe intramolecular anionic Diels—Alder reaction of diynes (I) and (III) affords arylnaphtalene lignans which are valuable precursors for the synthesis of natural products.
ChemInform Abstract: One‐Pot Synthesis of N‐Heterocycles by Tandem Carbamoylation—Oxidative Bromolactamization of ω‐Alkenylmagnesium Bromide.
Authors: Yamamoto Yasutomo , Takahama Yuji , Shimizu Misa , Ohara Ai , Miyawaki Akari , Tomioka Kiyoshi 
Published: October 2013

AbstractThe reaction of ω‐alkenylmagnesium bromides with tosyl isocyanate and subsequent oxidation with excess PhI(OAc)2 renders possible a one‐pot synthesis of bromolactones.
ChemInform Abstract: Phosphoramidite—Cu(OTf)2 Complexes as Chiral Catalysts for 1,3‐Dipolar Cycloaddition of Iminoesters and Nitroalkenes.
Authors: Castello Luis M. , Najera Carmen , Sansano Jose M. , Larranaga Olatz , de Cozar Abel , Cossio Fernando P. 
Published: October 2013

AbstractIt is demonstrated that BINOL derived phosphoramidite is an excellent ligand for the Cu(OTf)2 catalyzed 1,3‐dipolar cycloaddition of azomethine ylides and nitroalkenes.
ChemInform Abstract: Photocatalytic Cascade Carbon—Carbon Bond‐Forming Radical Reaction in Aqueous Media.
Authors: Yoshioka Eito , Kohtani Shigeru , Tanaka Eri , Miyabe Hideto 
Published: October 2013

AbstractA Ru‐catalyzed photolytic cascade radical reaction of dienic derivatives of O‐benzyl hydroxylamine with perhalogenated aliphatic halides is developed leading to functionalized pyrrolidinones as mixtures of diastereomers, also for compounds (III), or as mixtures of E/Z isomers.
ChemInform Abstract: Dual Organocatalytic Activation of Isatins and Formaldehyde tert‐Butyl Hydrazone: Asymmetric Synthesis of Functionalized 3‐Hydroxy‐2‐oxindoles.
Authors: Monge David , Crespo‐Pena Ana M. , Martin‐Zamora Eloisa , Alvarez Eleuterio , Fernandez Rosario , Lassaletta Jose M. 
Published: October 2013

AbstractDual activation of isatins and formaldehyde tert‐butyl hydrazone by 2,2′‐diamino‐1,1′‐binaphthalene (BINAM)‐derived bis(ureas) is the key to achieve high reactivity and excellent enantioselectivities in the synthesis of azo‐functionalized 3‐hydroxy‐2‐oxindoles.
ChemInform Abstract: Rhodium(III)‐Catalyzed Synthesis of Cyclopenta[b]pyrroles from 1,2‐Diketones, 2‐Aminopyridine, and Alkynes.
Authors: Du Juanjuan , Zhou Bing , Yang Yaxi , Li Yuanchao 
Published: October 2013

AbstractPreparation of the cyclopenta[b]pyrroles from 5‐methyl‐2‐(pyridin‐2‐ylamino)cyclopent‐2‐en‐1‐one (I) and internal alkynes or in a one‐pot manner from 5‐methylcyclopent‐2‐en‐1‐one (IV) with pyridylamine (V) and internal alkynes is presented.
ChemInform Abstract: Overcoming Product Inhibition in Catalysis of the Intramolecular Schmidt Reaction.
Authors: Motiwala Hashim F. , Fehl Charlie , Li Sze‐Wan , Hirt Erin , Porubsky Patrick , Aube Jeffrey 
Published: October 2013

AbstractThis reaction uses either TiCl4 as a catalyst or acetyl chloride as a procatalyst.
ChemInform Abstract: Synthesis and Biological Evaluation of 3‐(4‐Chloro‐phenyl)‐4‐substituted Pyrazole Derivatives.
Authors: Horrocks P. , Pickard M. R. , Parekh H. H. , Patel S. P. , Pathak Ravindra B. 
Published: October 2013

AbstractSome of the newly synthesized compounds show potential biological activity.
ChemInform Abstract: DDQ‐Induced Dehydrogenation of Heterocycles for C—C Double Bond Formation: Synthesis of 2‐Thiazoles and 2‐Oxazoles.
Authors: Li Xiangnan , Li Cheng , Yin Bing , Li Cong , Liu Ping , Li Jianli , Shi Zhen 
Published: October 2013

AbstractIn some cases the addition of CuI as a catalyst and raising the reaction temperature leads to the increase of yields.
ChemInform Abstract: Synthesis and Antitumor Activity Evaluation of γ‐Monofluorinated and γ,γ‐Difluorinated Goniothalamin Analogues.
Authors: Yang Yi , Yang Zhenjun , Cheng Chunru , Qing Fengling 
Published: October 2013

AbstractA library of novel γ,γ‐difluorinated Goniothalamin analogues is synthesized via Stille coupling and lactonization.
ChemInform Abstract: Highly Efficient Low Melting Mixture Catalyzed Synthesis of 1,8‐Dioxo‐dodecahydroxanthene Derivatives.
Authors: Li Peihe , Ma Feiping , Wang Ping , Zhang Zhanhui 
Published: October 2013

AbstractThis method uses a citric acid/dimethylurea melt as an easily recoverable reaction medium which can be reused at least five times without a significant loss in activity.
ChemInform Abstract: PhI(OCOCF3)2‐Mediated C—C Bond Formation Concomitant with a 1,2‐Aryl Shift in a Metal‐Free Synthesis of 3‐Arylquinolin‐2‐ones.
Authors: Liu Le , Lu Hang , Wang Hong , Yang Chao , Zhang Xiang , Zhang‐Negrerie Daisy , Du Yunfei , Zhao Kang 
Published: October 2013

AbstractA metal‐free, hypervalent iodine mediated cyclization reaction of cinnamamide derivatives to give 3‐arylquinolin‐2‐ones under mild conditions is developed.
ChemInform Abstract: Catalytic Enantioselective Synthesis of Tetrahydroisoquinolines and Their Analogues Bearing a C4 Stereocenter: Formal Synthesis of (+)‐(8S,13R)‐Cyclocelabenzine.
Authors: Chen Zhilong , Wang Zhaobin , Sun Jianwei 
Published: October 2013

Abstract1,2,3,4‐Tetrahydroisoquinolines with a C4 stereocenter can be formed by using a one‐pot multicomponent chiral phosphoric acid catalyzed transformation of a mixture of oxetane‐tethered benzaldehydes, amines, and a Hantzsch ester as reducing agent.
ChemInform Abstract: Direct Catalytic C—H Arylation of Imidazol[1,2‐a]pyridine with Aryl Bromides Using Magnetically Recyclable Pd—Fe3O4 Nanoparticles.
Authors: Lee Jaewoo , Chung Jooyoung , Byun Sang Moon , Kim B. Moon , Lee Chulbom 
Published: October 2013

AbstractThe reaction is highly regioselective and no other regioisomer is obtained.
ChemInform Abstract: Development of α‐Glucosidase Inhibitors by Room Temperature C—C Cross Couplings of Quinazolinones.
Authors: Pottabathini Narender , et al. et al. 
Published: October 2013

AbstractPyridylcyclopropyl quinazolinone derivatives are varied at the 6‐position by Suzuki—Miyaura cross coupling with aryl, heteroaryl, and alkyl boronic acids.
ChemInform Abstract: Improved Synthesis of N1‐Substituted Orotic Acid Derivatives (III)
Authors: Senger Nicholas A. , Bowler Jeannette T. , Mercado Rene S. , Lin Sidney , Wu Weiming 
Published: October 2013

Abstractinvolving the direct formation of 5‐bromouracil (II) from dihydrouracils (I) as the key step
ChemInform Abstract: Exploring the Unexplored Practical and Alternative Synthesis of 3‐(Trifluoromethyl)‐triazolopiperazine the Key Intermediate for Sitagliptin.
Authors: Nitlikar Lakshmikant H. , Darandale Sunil N. , Shinde Devanand B. 
Published: October 2013

AbstractA new, scalable, and extremely simple approach to synthesize the title triazolopiperazine (VII), a key intermediate in the preparation of the potent dipeptidyl peptidase‐IV inhibitor sitagliptin, as well as related 3‐trifluoromethyltriazolopyridines is developed.
ChemInform Abstract: Nickel‐Catalyzed Borylation of Halides and Pseudohalides with Tetrahydroxydiboron [B2(OH)4].
Authors: Molander Gary A. , Cavalcanti Livia N. , Garcia‐Garcia Carolina 
Published: October 2013

AbstractThe advantages of the presented borylation method are the use of a cheaper catalyst, the tolerance to more functional groups, the applicability to a number of heterocyclic systems, and the possibility to perform this reaction on a multigram scale.
ChemInform Abstract: NHC‐Mediated Cross‐Coupling of Sugar‐Derived Cyclic Nitrones with Enals: General and Efficient Synthesis of Polyhydroxylated Pyrolizidines and Indolizidines.
Authors: Xu Wen‐Yuan , Iwaki Ren , Jia Yue‐Mei , Zhang Wei , Kato Atsushi , Yu Chu‐Yi 
Published: October 2013

AbstractThe synthesized bicyclic iminosugars are assayed against various glycosidases, showing that aryl or alkyl substituents at C‐7 of pyrrolizidines or at C‐8 of indolizidines reduce the potency of the glycosidase inhibition.
ChemInform Abstract: Design and Synthesis of Carbohydrate Based Medium Sized Sulfur Containing Benzannulated Macrocycles: Applications of Sonogashira and Heck Coupling.
Authors: Hussain Altaf , Yousuf Syed Khalid , Sharma Deepak K. , Rao L. Mallikharjuna , Singh Baldev , Mukherjee Debaraj 
Published: October 2013

AbstractThe synthesis of 8‐, 9‐, 10‐, 11‐, and 13‐membered ring compounds having a carbohydrate ring fragment is established by intramolecular Sonogashira and Heck coupling reactions.
ChemInform Abstract: Depsidone and Diaryl Ether Derivatives from the Fungus Corynespora cassiicola, an Endophyte of Gongronema latifolium
Authors: Okoye Festus Basden C. , Lu Su , Nworu Chukwuemeka S. , Esimone Charles O. , Proksch Peter , Chadli Ahmed , Debbab Abdessamad 
Published: October 2013

Abstractisolation and structure elucidation of corynesidone D (I), corynether B (II) and corynether lactone A (III)
ChemInform Abstract: General Formation of Complex Tubular Nanostructures of Metal Oxides for the Oxygen Reduction Reaction and Lithium‐Ion Batteries.
Authors: Zhang Genqiang , Xia Bao Yu , Xiao Chong , Yu Le , Wang Xin , Xie Yi , Lou Xiong Wen 
Published: October 2013

AbstractNovel tube‐in‐tube nanostructures are synthesized for many binary and ternary metal oxides, including CuCo2O4, ZnCo2O4, CoMn2O4, ZnMn2O4, MnCo2O4, NiCo2O4, Mn2O3, Co3O4, NiO, and Fe2O3 by thermal annealing (380—450 °C, 4 h) of precursors obtained from carbon nanofibers dispersed in ethylene glycol with different metal acetates (reflux for 2 h).
Motion of Li+ in Nanoengineered LiBH4 and LiBH4:Al2O3 Comparison with the Microcrystalline Form
Authors: Epp Viktor , Wilkening Martin 
Published: October 2013

AbstractThe introduction of structural disorder and large volume fractions of different kinds of interfaces enables the manipulation of ion dynamics in solids. Variable‐temperature solid‐state NMR relaxometry is highly useful to study Li+ jump processes. If carried out as a function of frequency, the resulting NMR relaxation rates also contain information on the dimensionality (1D, 2D, or 3D) of the diffusion process. Recently, NMR relaxometry has revealed the 2D nature of Li hopping in LiBH4, and thus this hydride is an interesting ion conductor for further diffusion studies on the spatially confined motion of Li spins. Here, nanocrystalline LiBH4 and the two‐phase analogue LiBH4:Al2O3, which are prepared by ball milling, serve as interesting model systems to track the changes in NMR relaxation rates with respect to coarse‐grained, thermodynamically stable LiBH4. This reveals that interface (nano)engineering influences the hexagonal‐to‐orthorhombic phase transition and thus alters the ion‐transport properties of Li in one‐ and two‐phase LiBH4 towards higher diffusivities at lower temperatures.
A Chinese risk score model for identifying postprandial hyperglycemia without oral glucose tolerance test
Authors: Fu Qi , Sun Min , Tang Wei , Wang Zhixiao , Cao Mengdie , Zhu Zhenxin , Lu Lijie , Bi Yufang , Ning Guang , Yang Tao 
Published: October 2013

AbstractBackgroundThe aim of the study is to develop a risk score model for identifying postprandial hyperglycemia without oral glucose tolerance tests (OGTT) in Chinese population, and minimize the number of subjects needing further OGTT.MethodsMultivariable stepwise logistic regression was used to develop risk score models in a derivation cohort (7953 participants without known diabetes). The developed models were verified in a validation cohort (another 1455 subjects without known diabetes). All subjects had completed questionnaires, physical examination and OGTT. Performances of the risk score models were estimated using receiver operating characteristic curves.ResultsTwo risk score models for screening postprandial hyperglycemia were developed. The simple model used non‐invasive risk factors (age, height, weight, waist, systolic blood pressure, pulse, hypertension, dyslipidemia and family history of diabetes mellitus), and the full model contained additional variables [fasting blood glucose (FBG), triglyceride/high density lipoprotein cholesterol] obtainable by invasive laboratory tests. The area under receiver operating characteristic curve (AUC) of simple model was similar to FBG and glycated haemoglobin. The full model has the largest AUC [0.799 (0.789–0.809) and 0.730 (0.702–0.758)] in both derivation and validation cohorts (p < 0.001 compared with simple model, FBG, and glycated haemoglobin). At a cutoff point of 80, the sensitivity, specificity and percentage that needed subsequent OGTT were 75.97, 67.56 and 48.38%, respectively.ConclusionsWe developed a risk score model for screening postprandial hyperglycemia based on routine clinical information. It could effectively identify patients at high‐risk for postprandial hyperglycemia and remarkably reduce the number of subjects requiring OGTT. Copyright © 2013 John Wiley & Sons, Ltd.
Tamper Resistance Simulation on Algorithm Level Design
Authors: Yoshikawa Masaya , Asai Toshiya , Shiozaki Mitsuru , Fujino Takeshi 
Published: October 2013

SUMMARYRecently, side‐channel attacks have become a serious problem. These attacks estimate the secret keys of cryptography circuits embedded in hardware. In particular, the most threatening side‐channel attacks are differential power analysis and correlation power analysis, which use the correlation between information processing and power consumption, which are related to secret keys in cryptography circuits. Therefore, new measures are required to prevent confidential information in cryptography circuits from being leaked to side‐channel information, such as power consumption. When designing preventive measures, resistance to side‐channel attacks, for instance tamper resistance, must be evaluated. This study proposes a new simulation method by which tamper resistance can be verified in the algorithm and architecture design phases. Experimental results show the validity of the proposed simulation method. © 2013 Wiley Periodicals, Inc. Electr Eng Jpn, 186(2): 40–51, 2014; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.22342
Operation Assist by Vibration Suppression Control Using Impulse‐Shaped Signals for Power Assist Conveyance System
Authors: Yamamoto Yuichi , Uchida Masaki , Morita Yoshifumi , Hara Susumu 
Published: October 2013

SUMMARYThis paper presents an assist control method for a flexible parts conveyance task using a power assist conveyance system. The assist control method should be designed so as not only to suppress vibration but also to reduce the degradation of operating feel. For this purpose, multiple impulse‐shaped signals are used as feedforward signals in order to reduce the vibration of flexible parts during conveyance. In addition, the adjustment time is introduced to adjust the input timing of the impulse‐shaped signal and to suppress vibration. In order to improve the degradation of operating feel, the smaller amplitudes of the three impulse‐shaped signals are used and input repeatedly. The effectiveness of the proposed system was verified experimentally. © 2013 Wiley Periodicals, Inc. Electr Eng Jpn, 186(2): 31–39, 2014; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.22476
A heterogeneous flow model based on DD method for free surface fluid–structure interaction problems
Authors: Zhang Yi , Pin Facundo Del , Yim Solomon C. 
Published: October 2013

SUMMARYAn efficient heterogeneous flow model that combines incompressible viscous flow and potential flow(PF)(both) with free‐surface boundaries for fluid–structure interaction(FSI) problems was developed and solved numerically. In the model, the near field(viscous) fluid subdomain of the FSI simulation is described by the Navier–Stokes equations(NSE), whereas the far field(inviscid) subdomain is described by PF. This method is particularly suitable for modeling a large fluid domain while avoid solving the NSE at the far field, where the inviscid flow assumption is appropriate and adopting a simplified(e.g., PF) flow description reduces computing cost. Numerically, the NSE are solved using a FEM, and the PF is solved using a BEM. Free surface tracking is achieved through a hybrid level set method for the NSE and the mixed Eulerian–Lagrangian method for the PF. The coupling is based on a non‐overlapping DD method similar to the Dirichlet–Neumann method. At the interface between the two flow model subdomains, velocity and pressure are matched to ensure continuity of the corresponding variables at the common boundary. In this framework of the heterogeneous DD method, an explicit scheme is developed and implemented. The relation between this scheme and the classical Dirichlet–Neumann method for a homogeneous problem is revealed. Numerical examples demonstrating the capability of the method to model nonlinear wave phenomena and FSI problems with flexible structures are presented. Copyright © 2013 John Wiley & Sons, Ltd.
Accuracy of high‐order density‐based compressible methods in low Mach vortical flows
Authors: Shanmuganathan S. , Youngs D. L. , Griffond J. , Thornber B. , Williams R. J. R. 
Published: October 2013

SUMMARYAt low Mach numbers, Godunov‐type approaches, based on the method of lines, suffer from an accuracy problem. This paper shows the importance of using the low Mach number correction in Godunov‐type methods for simulations involving low Mach numbers by utilising a new, well‐posed, two‐dimensional, two‐mode Kelvin–Helmholtz test case. Four independent codes have been used, enabling the examination of several numerical schemes. The second‐order and fifth‐order accurate Godunov‐type methods show that the vortex‐pairing process can be captured on a low resolution with the low Mach number correction applied down to 0.002. The results are compared without the low Mach number correction and also three other methods, a Lagrange‐remap method, a fifth‐order accurate in space and time finite difference type method based on the wave propagation algorithm, and fifth‐order spatial and third‐order temporal accurate finite volume Monotone Upwind Scheme for Conservation Laws (MUSCL) approach based on the Godunov method and Simple Low Dissipation Advection Upstream Splitting Method (SLAU) numerical flux with low Mach capture property. The ability of the compressible flow solver of the commercial software, ANSYS FLUENT, in solving low Mach flows is also demonstrated for the two time‐stepping methods provided in the compressible flow solver, implicit and explicit. Results demonstrate clearly that a low Mach correction is required for all algorithms except the Lagrange‐remap approach, where dissipation is independent of Mach number. © 2013 Crown copyright. International Journal for Numerical Methods in Fluids. © 2013 John Wiley & Sons, Ltd.
Suppression of adrenal gland‐derived epinephrine enhances the corticosterone‐induced antinociceptive effect in the mouse formalin test
Authors: Kang S.Y. , Roh D.H. , Kim H.W. , Han H.J. , Beitz A.J. , Lee J.H. 
Published: October 2013

AbstractBackgroundThere is both clinical and experimental evidence to support the application of corticosterone in the management of inflammation and pain. Corticosterone has been used to treat painful inflammatory diseases and can produce antinociceptive effects. Epinephrine is synthesized from norepinephrine by the enzyme phenylethanolamine N‐methyltransferase (PNMT) and works as an endogenous adrenoceptor ligand secreted peripherally by the adrenal medulla. It is currently unclear whether corticosterone's antinociceptive effect is associated with the modulation of peripheral epinephrine.MethodsWe first determined whether exogenous corticosterone treatment actually produced an antinociceptive effect in a formalin‐induced pain model, and then examined whether this corticosterone‐induced antinociceptive effect was altered by suppression of adrenal‐derived epinephrine, using the following three suppression methods: (1) inhibition of the PNMT enzyme; (2) blocking peripheral epinephrine receptors; and (3) adrenalectomy.ResultsExogenous treatment with corticosterone at a high dose (50 mg/kg), but not at lower doses (5, 25 mg/kg), significantly reduced pain responses in the late phase. Moreover, injection of 2,3‐dichloro‐a‐methylbenzylamine, a PNMT enzyme inhibitor, (10 mg/kg) before corticosterone treatment caused a leftward shift in the dose‐response curve for corticosterone and injection of propranolol (5 mg/kg), but not phentolamine, also shifted the dose‐response curve to the left during the late phase. Chemical sympathectomy with 6‐hydroxydopamine had no effect on corticosterone‐induced antinociceptive effect, but injection of a low dose of corticosterone produced an antinociceptive effect in adrenalectomized animals.ConclusionsThese results demonstrate that suppression of epinephrine, derived from adrenal gland, enhances the antinociceptive effect of exogenous corticosterone treatment in an inflammatory pain model.
Functioning of the hypothalamic–pituitary–adrenal and growth hormone axes in frequently unexplained disorders: Results of a population study
Authors: Aggarwal V.R. , Macfarlane G.J. , Tajar A. , Mulvey M.R. , Power A. , Ray D. , McBeth J. 
Published: October 2013

AbstractBackgroundThe aim of the study was to test the hypothesis that associations with specific stress systems [hypothalamic–pituitary–adrenal (HPA) and growth hormone (GH) axes] would increase as the number of unexplained disorders increased while accounting for the possible confounding effects of psychosocial factors.MethodsA cross‐sectional study identified those reporting chronic widespread pain, irritable bowel syndrome, chronic orofacial pain and chronic fatigue. Of the 1315 subjects, disorder status was available for 1180 (89.7%), of whom 766 (64.9%) reported no disorders, 277 (23.5%) reported one and 137 (11.6%) reported two or more. Eighty subjects were sought from each group for assessment of HPA (morning 8:00 a.m. and evening 10:00 p.m. saliva, and post‐dexamethasone serum cortisol levels) and GH [serum insulin‐like growth factor 1 (IGF‐1) level] axis function. Validated questionnaires informed current psychological state.ResultsTwo hundred twenty‐seven subjects participated [79 (35%) with no disorders, 78 (34%) with one disorder and 70 (31%) with two or more disorders]. There were no significant associations (p < 0.05) between individual disorders or an increasing disorder load with any of the neuroendocrine levels measured: saliva/serum cortisol, IGF‐1 and dehydroepiandrosterone. Psychosocial factors were independently associated with disorders and with an increasing disorder load: health anxiety p < 0.01, anxiety p < 0.01, depression p < 0.01, life events p = 0.03.ConclusionAlthough previous studies have shown that stress axis function acts to moderate the risk of onset of some of these disorders, the present study shows that the degree of dysfunction is not correlated with a corresponding increasing load of disorders. The uncertainty surrounding the role of these biomarkers in the aetiology of unexplained disorders needs further investigation.