bluuebunny/crossref_metadata_2025_split huggingface dataset:
Centralized vs. Decentralized Nursing Stations: An Evaluation of the Implications of Communication Technologies in Healthcare
Authors: Bayramzadeh Sara , Alkazemi Mariam F. 
Published: February 2015

OBJECTIVE: This study aims to explore the relationship between the nursing station design and use of communication technologies by comparing centralized and decentralized nursing stations. BACKGROUND: The rapid changes in communication technologies in healthcare are inevitable. Communication methods can change the way occupants use a space. In the meantime, decentralized nursing stations are emerging as a replacement for the traditional centralized nursing stations; however, not much research has been done on how the design of nursing stations can impact the use of communication technologies. METHODS: A cross sectional study was conducted using an Internet-based survey among registered nurses in a Southeastern hospital in the United States. Two units with centralized nursing stations and two units with decentralized nursing stations were compared in terms of the application of communication technologies. A total of 70 registered nurses completed the survey in a 2-week period. RESULTS: The results revealed no significant differences between centralized and decentralized nursing stations in terms of frequency of communication technologies used. However, a difference was found between perception of nurses toward communication technologies and perceptions of the use of communication technologies in decentralized nursing stations. CONCLUSIONS: Although the study was limited to one hospital, the results indicate that nurses hold positive attitudes toward communication technologies. The results also reveal the strengths and weaknesses of each nursing station design with regard to communication technologies.
Positive Distraction and the Rehabilitation Hospitals of João Filgueiras Lima
Authors: Campagnol Gabriela , Shepley Mardelle McCuskey 
Published: February 2015

OBJECTIVE: This article discusses the use of positive distraction, an evidence-based design approach, in rehabilitation hospitals in Brazil through the work of João Filgueiras Lima (“Lelé”). BACKGROUND: In many parts of the world architects may not formally incorporate theories of positive distraction and evidence-based design, but there are multiple international examples of health facility architects and designers that use nature, daylighting, art, and social interaction to enhance the healing experience. The work of the Brazilian architect João Filgueiras Lima is a particularly salient example. Lima has been a dominant figure in 20th and 21st century Brazilian architecture and the architect of several rehabilitation facilities. METHODS: First positive distraction is defined as it relates to nature and art, and in the context of rehabilitation hospitals. Second, rehabilitation facilities are defined. The discussion then focuses on awareness of evidence-based design in Latin America. Next, Brazilian healthcare architecture is discussed along with the history of the Brazilian Sarah rehabilitation hospitals designed by Lelé and Lelé's role in the history of Brazilian architecture. Last we look at Lelé's use of positive distraction. RESULTS: Despite Lelé's recognition in Brazil, his work has not gained much international exposure. Lelé played a critical role in the design of the Sarah facilities and served on the board of directors for the Technological Center of the Sarah Network (CTRS) in Brazil from 1992 to 2009. Based on our review of his work it was clear that Lelé used positive distraction as a tool for creating healing environments. CONCLUSIONS: In spite of the lack of formal integration of evidence-based design in healthcare architecture in Latin America, many of its basic tenets have been incorporated in Brazilian rehabilitation hospitals. Lelé's projects are a clear example of this phenomenon and demonstrate an alignment between research and practitioner objectives. The presence of nature, art, and natural light in his rehabilitation hospitals serves as a model for evidence-based design in facilities throughout the world and presents an opportunity to measure the benefits of positive distraction on rehabilitation patient outcomes.
Ten Trends Transforming Cancer Care and Their Effects on Space Planning for Academic Medical Centers
Authors: Bloom Mara , Markovitz Sarah , Silverman Susan , Yost Carl 
Published: February 2015

Objective: This article aims to define the major trends currently affecting space needs for academic medical center (AMC) cancer centers. It will distinguish between the trends that promote the concentration of services with those that promote decentralization as well as identify opportunities for achieving greater effectiveness in cancer care space planning. Background: Changes in cancer care—higher survival rates, increased clinical trials, new technology, and changing practice models—increasingly fill hospitals’ and clinicians’ schedules and strain clinical space resources. Conflicts among these trends are concentrating some services and dispersing others. As a result, AMCs must expand and renovate intelligently to continue providing state-of-the-art, compassionate care. Conclusions: Although the typical AMC cancer center can expect to utilize more space than it would have 10 years ago, a deeper understanding of the cancer center enterprise can lead to opportunities for more effectively using available facility resources. Each AMC must determine for itself the appropriate balance of patient volume, clinical activity, and services between its main hospital campus and satellite branches. As well, space allocation should be flexible, as care trends, medical technology, and the provider’s own priorities shift over time. The goal isn’t necessarily more space—it’s better space.
Differentiating malignant hypertension-induced thrombotic microangiopathy from thrombotic thrombocytopenic purpura
Authors: Khanal Nabin , Dahal Sumit , Upadhyay Smrity , Bhatt Vijaya Raj , Bierman Philip J. 
Published: February 2015

Objectives: Malignant hypertension can cause thrombotic microangiopathy (TMA) and the overall presentation may mimic thrombotic thrombocytopenic purpura (TTP). This presents a dilemma of whether or not to initiate plasma exchange. The objective of the study was to determine the clinical and laboratory manifestations of malignant hypertension-induced TMA, and its outcomes. Methods: Using several search terms, we reviewed English language articles on malignant hypertension-induced TMA, indexed in MEDLINE by 31 December 2013. We also report a new case. All these cases were analyzed using descriptive statistics. Results: A total of 19 patients, with 10 males, had a median age of 38 years at diagnosis; 58% had a history of hypertension. Mean arterial pressure at presentation was 159 mmHg (range 123–190 mmHg). All had prominent renal dysfunction (mean creatinine of 5.2 mg/dl, range 1.7–13 mg/dl) but relatively modest thrombocytopenia (mean platelet count of 60 × 103/µl, range 12–131 × 103/µl). Reported cases ( n = 9) mostly had preserved ADAMTS-13 activity (mean 64%, range 18–96%). Following blood pressure control, the majority had improvement in presenting symptoms (100%) and platelet counts (84%); however, only 58% had significant improvement in creatinine. More than half (53%) needed hemodialysis. One patient died of cardiac arrest during pacemaker insertion. Conclusion: Prior history of hypertension, high mean arterial pressure, significant renal impairment but relatively modest thrombocytopenia and lack of severe ADAMTS-13 deficiency (activity <10%) at diagnosis are clues to diagnose malignant hypertension-induced TMA. Patients with malignant hypertension respond well to antihypertensive agents and have favorable nonrenal outcomes.
Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade
Authors: Magwenzi Simbarashe , Woodward Casey , Wraith Katie S. , Aburima Ahmed , Raslan Zaher , Jones Huw , McNeil Catriona , Wheatcroft Stephen , Yuldasheva Nadira , Febbriao Maria , Kearney Mark , Naseem Khalid M. 
Published: February 2015

Key PointsoxLDL binds platelet CD36 to stimulate tyrosine kinase– and PKC-dependent activation of NOX2 and generation of ROS. oxLDL- and hyperlipidemia-induced ROS mediate platelet desensitization to inhibitory cGMP signaling to facilitate platelet activation and thrombus formation.
Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia
Authors: Ranganathan Parvathi , Yu Xueyan , Santhanam Ramasamy , Hofstetter Jessica , Walker Alison , Walsh Katherine , Bhatnagar Bhavana , Klisovic Rebecca , Vasu Sumithira , Phelps Mitch A. , Devine Steven , Shacham Sharon , Kauffman Michael , Marcucci Guido , Blum William , Garzon Ramiro 
Published: February 2015

Key Points
Decitabine priming increases antileukemic effects of selinexor in AML in vitro and in vivo. Decitabine priming allows for decreasing the dose of selinexor in patients, thus increasing tolerability without affecting antileukemic activity.
Content delivery to newly forming Weibel-Palade bodies is facilitated by multiple connections with the Golgi apparatus
Authors: Mourik Marjon J. , Faas Frank G. A. , Zimmermann Hans , Voorberg Jan , Koster Abraham J. , Eikenboom Jeroen 
Published: February 2015

Key Points
WPBs stay connected to the Golgi apparatus until vesicle formation is completed. During biogenesis at the Golgi, WPBs increase in size through the addition of nontubular VWF.
Incorporating within- and between-patch resource selection in identification of critical habitat for brood-rearing greater sage-grouse
Authors: Dzialak Matthew R , Olson Chad V , Webb Stephen L , Harju Seth M , Winstead Jeffrey B 
Published: February 2015

Abstract

Introduction
Incorporating information on animal behavior in resource-based predictive modeling (e.g., occurrence mapping) can elucidate the relationship between process and spatial pattern and depict habitat in terms of its structure as well as its function. In this paper, we assigned location data on brood-rearing greater sage-grouse (Centrocercus urophasianus) to either within-patch (encamped) or between-patch (traveling) behavioral modes by estimating a movement-based relative displacement index. Objectives were to estimate and validate spatially explicit models of within- versus between-patch resource selection for application in habitat management and compare these models to a non-behaviorally adjusted model.

Results
A single model, the vegetation and water resources model, was most plausible for both the encamped and traveling modes, including the non-behaviorally adjusted model. When encamped, sage-grouse selected for taller shrubs, avoided bare ground, and were closer to mesic areas. Traveling sage-grouse selected for greater litter cover and herbaceous vegetation. Preference for proximity to mesic areas was common to both encamped and traveling modes and to the non-behaviorally adjusted model. The non-behaviorally adjusted map was similar to the encamped model and validated well. However, we observed different selection patterns during traveling that could have been masked had behavioral state not been accounted for.

Conclusions
Characterizing habitat that structured between-patch movement broadens our understanding of the habitat needs of brood-rearing sage-grouse, and the combined raster surface offers a reliable habitat management tool that is readily amenable to application by GIS users in efforts to focus sustainable landscape management.
Wnt signaling downregulated after sonic hedgehog activation negatively associates with tumor repopulation
Authors: Ma Jingjing , Cheng Jin , Gong Yanping , Tian Ling , Huang Qian 
Published: February 2015

Abstract
Tumor repopulation after radiotherapy is a big obstacle for clinical cancer therapy. The molecular mechanisms of tumor cell repopulation after radiotherapy remain unclear. This study investigated the role of sonic hedgehog (SHH) and Wnt signaling pathways in tumor repopulation after radiotherapy in an in vitro repopulation model. In this model, irradiated dying tumor cells functioned as feeder cells, while luciferase-labeled living tumor cells acted as reporter cells. Proliferation of reporter cells was measured by bioluminescence imaging. Results showed that irradiated dying HT29 and Panc1 cells significantly stimulated the repopulation of their living cells. In HT29 and Panc1 cells, radiation significantly inhibited Wnt activity. In the irradiated dying HT29 and Panc1 cells, the activated nuclear β-catenin was significantly decreased. Wnt agonist 68166 significantly decreased, whereas Wnt antagonist significantly increased repopulation in HT29 and Panc1 tumor cells in a dose dependent manner. β-catenin shRNA significantly promoted tumor cell repopulation. The level of secreted frizzled related protein-1, hedgehog, and Gli1 were increased in irradiated cells. Our results highlighted the interaction between Wnt and SHH signaling pathways in dying tumor cells and suggested that downregulation of Wnt signaling after SHH activation is negatively associated with tumor repopulation.
Modeling autosomal recessive cutis laxa type 1C (ARCL1C) in mice reveals distinct functions of Ltbp-4 isoforms
Authors: Bultmann-Mellin Insa , Conradi Anne , Maul Alexandra C. , Dinger Katharina , Wempe Frank , Wohl Alexander P. , Imhof Thomas , Wunderlich F. Thomas , Bunck Alexander C. , Nakamura Tomoyuki , Koli Katri , Bloch Wilhelm , Ghanem Alexander , Heinz Andrea , von Melchner Harald , Sengle Gerhard , Sterner-Kock Anja 
Published: February 2015

AbstractRecent studies revealed an important role for LTBP-4 in elastogenesis. Its mutational inactivation in humans causes autosomal recessive cutis laxa type 1C (ARCL1C), which is a severe disorder caused by defects of the elastic fiber network. Although the mechanisms underlying the disease were discovered based on similar elastic fiber abnormalities exhibited by mice lacking the short Ltbp-4 isoform (Ltbp4S-/-), the murine phenotype does not replicate ARCL1C. We therefore inactivated both Ltbp-4 isoforms in the mouse germline to model ARCL1C. Comparative analysis of Ltbp4S-/- and Ltbp4 null (Ltbp4-/-) mice identified Ltbp-4L as an important factor for elastogenesis and postnatal survival with distinct tissue expression patterns and specific molecular functions. We identified fibulin-4 as a novel interaction partner of both Ltbp-4 isoforms and demonstrated that at least Ltbp-4L expression is essential for ECM incorporation of fibulin-4. Overall, our results contribute to the current understanding of elastogenesis and provide of an animal model of ARCL1C.
Self-organization of core Golgi material is independent of COPII-mediated endoplasmic reticulum export
Authors: Schuberth Christian E. , Tängemo Carolina , Coneva Cvetalina , Tischer Christian , Pepperkok Rainer 
Published: February 2015

ABSTRACT
The Golgi is a highly organized and dynamic organelle that receives and distributes material from and to the endoplasmic reticulum (ER) and the endocytic pathway. One open question about Golgi organization is whether it is solely based on ER-to-Golgi transport. Here, we analyzed the kinetics of Golgi breakdown in the absence of COPII-dependent ER export with high temporal and spatial resolution using quantitative fluorescence microscopy. We found that Golgi breakdown occurred in two phases. While Golgi enzymes continuously redistributed to the ER, we consistently observed extensive Golgi fragmentation at the beginning of the breakdown, followed by microtubule-dependent formation of a Golgi remnant structure (phase 1). Further Golgi disintegration occurred less uniformly (phase 2). Remarkably, cisternal Golgi morphology was lost early in phase 1 and Golgi fragments instead corresponded to variably sized vesicle clusters. These breakdown intermediates were devoid of COPI-dependent recycling material, but contained typical ‘core’ Golgi components. Furthermore, Golgi breakdown intermediates were able to disassemble and reassemble following cell division, indicating that they retained important regulatory capabilities. Taken together, these findings support the view that Golgi self-organization exists independently of ER-to-Golgi transport.
Automotive Three Way Catalytic Activity of Fe–Ni/Ceria
Authors: Satsuma Atsushi , Ueda Kakuya , Ito Yoshihiro , Ang Cheen Aik , Ohyama Junya 
Published: February 2015

Abstract
Ceria-supported transition metals have been investigated as non-platinum group metal automotive three way catalysts. Fe–Ni/CeO2 catalyst was found to be active for the simultaneous removal of NO, C3H6, and CO above 300 °C under a simulated automotive exhaust.
Syntheses and Optical Properties of BODIPY Derivatives Based on Imidazo[1,5-a]pyridine
Authors: Hu Jinfa , Li Yu , Wu Yuxiao , Liu Wei , Wang Yong , Li Yahong 
Published: February 2015

Abstract
A series of covalently linked dyads 3a–3e incorporating imidazo[1,5-a]pyridine derivatives with boron dipyrromethene (BODIPY) fragment have been synthesized by a concise procedure. The absorptions with high molar extinction coefficient for 3a–3e have been obtained in CH2Cl2 solution. With substituent groups of different electronic nature at the 3-position of imidazo[1,5-a]pyridine moiety, the emission maxima of dyads 3a–3e change from yellow to red at solid state under ambient conditions.
System-and-Activity-Based Approach in Teaching to Primary Schoolchildren
Authors: Мыльникова  , Mylnikova N. 
Published: March 2015

The paper makes a case for efficiency of system-and-activity-based approach when implemented in the practice of primary school teaching.
The author highlights the unconventional educational methods and techniques, to be used by primary school children, such as: discussion of
problems and topical issues; hypothesizing; completion of creative tasks, aimed at enhancing learners’ communicative activities.
Perceived Autonomy in Old Age scale: Factor structure and psychometric properties of the Polish adaptation
Authors: Kroemeke Aleksandra 
Published: February 2015

CelPoczucie autonomii – możliwość wyboru i decydowania – jest jednym z wyznaczników pozytywnego i aktywnego starzenia się. Celem badań było przeprowadzenie polskiej adaptacji Skali Postrzeganej Autonomii (SPA), określenie jej wewnętrznej struktury i właściwości psychometrycznych: rzetelności oraz trafności teoretycznej i różnicowej.MetodaW badaniu wzięło udział 277 seniorów (K=187; M=90), bez zaburzeń funkcji poznawczych, w wieku 60–100 lat (M=77,39; SD=9,20). Poza SPA wykorzystano skale ADL i IADL (ocena samodzielności funkcjonowania), Kwestionariusz Stanu Emocjonalnego (pomiar emocji pozytywnych i negatywnych) i WHOQoL-Brief (ocena jakości życia uwarunkowanej stanem zdrowia).WynikiW efekcie eksploracyjnej i konfirmacyjnej analizy czynnikowej zbudowano jednowymiarowe narzędzie z pięcioma pozycjami. Współczynniki rzetelność skali liczone metodą zgodności wewnętrznej i test-retest przyjęły wartości ≥0,80. Odnotowano dodatnie korelacje skali ze wskaźnikami ADL, IADL, somatyczną i psychologiczną domeną jakości życia i emocjami pozytywnymi oraz ujemne – z emocjami negatywnymi.WnioskiOtrzymane wyniki wskazały na bardzo dobrą rzetelność i trafność polskiej adaptacji SPA. Narzędzie może być wykorzystywane jako predyktor i/lub wskaźnik pomyślnego starzenia się i jakości życia seniorów.
Diagnosis and Management of Schwannomas Originating from the Cervical Vagus Nerve
Authors: Behuria S , Rout TK , Pattanayak S 
Published: February 2015

IntroductionA schwannoma is a benign, slow growing, encapsulated nerve sheath tumour. Presentation of a schwannoma is a diagnostic and management challenge.MethodsInternet searches of PubMed/MEDLINE®for all articles listing schwannomas of the vagus nerve in the cervical/neck region (1980–2012) were undertaken to ascertain diagnostic pitfalls. The references of all articles were cross-checked to include all pertinent contributions. Further articles were traced through reference lists.ResultsSchwannomas are solitary, well circumscribed and medial to the carotid sheath. Preoperative diagnoses of schwannomas in the lateral part of the neck can cause confusion with its nerve of origin (ie whether it arises from the vagus nerve or a sympathetic chain). Computed tomography and magnetic resonance imaging reveal valuable information regarding the location and origin of the tumour as well as aiding surgical planning. The diagnosis can be confirmed intraoperatively. Postoperative recovery of neurological function is dependent on the type of surgery. Histopathological studies searching for classical features and immunohistochemical staining for S100 also confirm the diagnosis.ConclusionsSchwannomas should be considered in the differential diagnoses of unusual masses in the neck. Preoperative imaging elicits valuable information regarding the location and origin of schwannomas and histopathology confirms the diagnosis.
Incidental Non-Inguinals Hernias in Totally Extra-Peritoneal Hernia Repair
Authors: Old OJ , Kulkarni SR , Hardy TJ , Slim FJ , Emerson LG , Bulbulia RA , Whyman MR , Poskitt KR 
Published: February 2015

Introduction Totally extra-peritoneal (TEP) inguinal hernia repair allows identification and repair of incidental non-inguinal groin hernias. We assessed the prevalence of incidental hernias during TEP inguinal hernia repair and identified the risk factors for incidental hernias. Materials and Methods Consecutive patients undergoing TEP repair from May 2005 to November 2012 were the study cohort. Inspection for ipsilateral femoral, obturator and rarer varieties of hernia was undertaken during TEP repair. Patient characteristics and operative findings were recorded on a prospectively collected database. Results A total of 1,532 TEP repairs were undertaken in 1,196 patients. Ninety-three patients were excluded due to incomplete data, leaving 1,103 patients and 1,404 hernias for analyses (1,380 male; 802 unilateral and 301 bilateral repairs; median age, 59 years). Among the 37 incidental hernias identified (2.6% of cases), the most common type of incidental hernia was femoral (n=32, 2.3%) followed by obturator (n=2, 0.1%). Increasing age was associated with an increased risk of incidental hernia, with a significant linear trend (p<0.01). The risk for patients >60 years of age was 4.0% vs 1.4% for those aged <60 years (p<0.01). Incidental hernias were found in 29.2% of females vs 2.2% of males, (p<0.0001). Risk of incidental hernia in those with a recurrent inguinal hernia was 3.0% vs 2.6% for primary repair (p=0.79). Conclusions Incidental hernias during TEP inguinal hernia repair were found in 2.6% of cases and, though infrequent, could cause complications if left untreated. The risk of incidental hernia increased with age and was significantly higher in patients aged >60 years and in females.
Surgical Resection of a Liver Metastasis from Breast Cancer
Authors: Selvakumar D , Dube M , Matey P 
Published: February 2015

We report a case of a solitary liver metastasis from breast cancer in a 65-year-old woman. The patient underwent a mastectomy and axillary lymph node clearance for right breast cancer in 1990. A solitary metastasis was found in the left lobe of the liver by ultrasonography, 20 years after the initial mastectomy. A left lateral segmentectomy was performed in January 2011 and adjuvant hormonal therapy was also initiated. At present, she remains disease free. This case demonstrates the implementation of liver resection to provide an effective treatment for metachronous metastatic breast cancer. We encourage surgeons to offer suitable patients this surgical treatment option, which is shown to provide a survival benefit.