bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors of children's low birth weight and infant mortality in Bangladesh: Evidence from binary logistic regression and Cox PH models
Authors: Islam Md. Johurul , Chowdhury Mashfiqul Huq , Rahman Mohammad Mafizur , Rahman Zubaidur 
Published: August 2024

AbstractBackgroundLow birth weight is recognized as a pivotal risk factor affecting child survival and growth. Although Bangladesh has made commendable progress in public health, an infant mortality rate of 38 per 1000 live births and a 16% prevalence of low birth weight remain significant concerns compared to other developing countries. This situation poses a significant challenge for the formulation of future health policies in Bangladesh. As a result, this study aims to identify potential risk factors contributing to low birth weight and infant mortality among children in Bangladesh.MethodsThe data is extracted from the 2014 Bangladesh Demographic and Health Survey. The response variables are infant mortality and low birth weight. In the bivariate analysis, Log‐rank tests and Chi‐square tests of independence were conducted. Cox proportional hazards and binary logistic regression models were utilized to determine the impact of risk factors on infant mortality and low birth weight.ResultsThis study identified several significant factors associated with children's low birth weight, including wealth index, parental education, birth order, twin births, mother's body mass index, and child sex. Additionally, wealth index, parental education, twin status, media exposure, birth order, antenatal care visits, prenatal care assistance, and low birth weight were identified as potential risk factors for infant mortality in Bangladesh.ConclusionThis study revealed that maternal and child characteristics, along with knowledge about child health care during pregnancy, can potentially reduce the risk of low birth weight and infant mortality among children in Bangladesh. To improve child health and survival, policymakers should prioritize community‐based health education programs, and encourage parents to seek healthcare information from institutional medical facilities during pregnancy and after birth.
Evaluating the diagnostic potential of gelsolin in gestational diabetes mellitus: A case–control study
Authors: Tokgöz Çakır Betül , Aktemur Gizem , Karabay Gülşan , Şeyhanlı Zeynep , Topkara Sucu Serap , Eroğlu Ömer Osman , Yılmaz Ergani Seval , İskender Can Tekin 
Published: August 2024

AbstractObjectivesTo investigate the association between gestational diabetes mellitus (GDM) and blood levels of gelsolin (an inflammation‐related protein thought to be reduced in type 2 diabetes mellitus) and to determine its role in potential diagnosis and neonatal outcomes.MethodsThis prospective case–control study was conducted at Ankara Etlik City Hospital between November 2023 and February 2024 with 40 pregnant women with GDM and 40 normoglycemic women. Pregnant women aged 18–40 years who were in their 24th to 28th week of pregnancy and had no known chronic disease were included in the present study and it was investigated as to whether there was a significant difference between the two groups in terms of gelsolin levels and neonatal outcome.ResultsGelsolin level was statistically significantly lower in the GDM group than in the control group (P = 0.004). In patients with fasting blood glucose <96 mg/dL, maternal serum gelsolin levels were associated with GDM, with a cut‐off of 15.38 or less, showing a sensitivity of 73%, a specificity of 67%, and an area under the curve (AUC) of 0.703 (95% confidence interval [CI] 0.576–0.810, P = 0.002). There was no difference between groups in terms of adverse obstetric outcomes, but gelsolin levels were associated with composite neonatal adverse outcome (macrosomia, Apgar score at 5 min less than 7, preterm birth, need for neonatal intensive care), with a cut‐off value of 16.66 or less showing a sensitivity of 84.6%, specificity of 40.7% and AUC of 0.644 (95% CI 0.529–0.748, P = 0.031).ConclusionGelsolin could potentially serve as a promising biomarker for the diagnosis of GDM.
Association between Life's essential 8 and stress urinary incontinence in women from the National Health and nutrition examination survey 2005–2018: A cross‐sectional study
Authors: Xu Xiaoping , Wu Han , Xu Xiaofang , Liu Ruiqian 
Published: August 2024

AbstractObjectiveStress urinary incontinence (SUI) may be associated with cardiovascular disease. Life's Essential 8 (LE8), a recently updated measure of cardiovascular health (CVH), has been investigated for its association with SUI in women.MethodsThe study adopted a cross‐sectional design with national scope, incorporating 9332 women aged 20 and above, selected from the National Health and Nutrition Examination Survey dataset from 2005 to 2018. The LE8 metric, which varies from 0 to 100, was evaluated based on the criteria set by the American Heart Association. SUI was determined based on self‐report. To evaluate these correlations, we employed models with multivariable logistic variables and a restricted cubic spline.ResultsIn the cross‐sectional study, a total of 9332 participants were included (weighted average age, 52.23 years), and 4274 had SUI (weighted percentage, 48.64%). Considering potential confounders, it was found that higher LE8 scores were associated with lower odds of SUI (odds ratio [OR] for each 10‐point increase was 0.83; 95% confidence interval [CI], 0.80–0.87). Compared to participants with lower LE8 scores, those with higher LE8 scores had a 57% lower probability of developing SUI. There was a statistically significant association between LE8 score and SUI among participants who were middle‐aged, non‐Hispanic white, had higher levels of education and income, and were living with a partner.ConclusionAccording to this study, there was an association between increase in Life's Essential 8 and reduction in SUI risk. Therefore, promoting optimal CVH may associate with reducing SUI in women.
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Authors: Zhou Chongyang , Guo Weibin , Fan Jiayao , Shi Naien , Zhao Yi , Yang Xu , Ding Zhen , Han Min , Huang Wei 
Published: August 2024

The unique structure of RP perovskite gives it the possibility of high ionic conductivity. It can potentially become an ideal solid electrolyte, which can further promote its development and application in solid‐state batteries.
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One step further in mistreatment research: Assessing the scalability of the Explicit Discrimination Scale among Brazilian working‐age adult respondents
Authors: Bastos João L. , Bernardo Fabiula R. , Reichenheim Michael E. 
Published: August 2024

AbstractThough the Explicit Discrimination Scale (EDS) has been subjected to extensive psychometric evaluation in Brazil, the instrument has yet to be comprehensively assessed among working‐age adult respondents in the country. This study aimed to fill this knowledge gap. Data from around 1200 diverse members of a cohort investigation were used to examine: (1) the positioning of respondents along the continuum of the EDS latent trait; (2) how well the corresponding items represent the EDS construct map; and (3) the extent to which the EDS items follow their expected levels of intensity. We assessed these properties with Loevinger's H, Guttman errors, and Item Response Theory parameters. Findings suggest that two abridged versions of the instrument—but especially the eight‐item EDS—may adequately arrange respondents along the latent trait continuum. Analyses also revealed that scale items are reasonably spread over the construct map, with some discrepancy between the expected levels of intensity and their empirical positioning in the corresponding plot. The shortened versions of EDS have good psychometric properties among Brazilian working‐age adult respondents. In addition to examining the invariance of the EDS across multiple groups, future psychometric evaluations should assess the external validity of the scale.
Nrf2‐mediated adenylosuccinate lyase promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma cells through ferroptosis escape
Authors: Hsu Tung‐Wei , Wang Wan‐Yu , Chen Alvin , Chiu Ching‐Feng , Liao Po‐Hsiang , Chen Hsin‐An , Su Chih‐Ming , Shen Shih‐Chiang , Tsai Kuei‐Yen , Wang Tzu‐Hsuan , Su Yen‐Hao 
Published: August 2024

AbstractPancreatic cancer has one of the highest fatality rates and the poorest prognosis among all cancer types worldwide. Gemcitabine is a commonly used first‐line therapeutic drug for pancreatic cancer; however, the rapid development of resistance to gemcitabine treatment has been observed in numerous patients with pancreatic cancer, and this phenomenon limits the survival benefit of gemcitabine. Adenylosuccinate lyase (ADSL) is a crucial enzyme that serves dual functions in de novo purine biosynthesis, and it has been demonstrated to be associated with clinical aggressiveness, prognosis, and worse patient survival for various cancer types. In the present study, we observed significantly lower ADSL levels in gemcitabine‐resistant cells (PANC‐1/GemR) than in parental PANC‐1 cells, and the knockdown of ADSL significantly increased the gemcitabine resistance of parental PANC‐1 cells. We further demonstrated that ADSL repressed the expression of CARD‐recruited membrane‐associated protein 3 (Carma3), which led to increased gemcitabine resistance, and that nuclear factor erythroid 2‐related factor 2 (Nrf2) regulated ADSL expression in parental PANC‐1 cells. These results indicate that ADSL is a candidate therapeutic target for pancreatic cancer involving gemcitabine resistance and suggest that the Nrf2/ADSL/Carma3 pathway has therapeutic value for pancreatic cancer with acquired resistance to gemcitabine.
Expression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma
Authors: Xu Xinnan , Jin Kaiqi , Xu Xiaoxiong , Yang Yang , Zhou Bin 
Published: August 2024

AbstractBackgroundLung cancer continues to be a prevalent cause of cancer‐related deaths worldwide, with lung squamous carcinoma (LUSC) being a significant subtype characterized by comparatively low survival rates. Extensive molecular studies on LUSC have been conducted; however, the clinical importance of cell‐cycle‐associated genes has rarely been examined. This study aimed to investigate the relationship between these genes and LUSC.MethodsThe expression trends of genes related to the cell cycle in a group of patients with LUSC were analyzed. Clinical information and mRNA expression data were obtained from The Cancer Genome Atlas via cBioportal. Multiple analyses have been performed to investigate the association between these genes and LUSC.ResultsThree clusters were identified based on the mRNA expression of 124 cell cycle‐associated genes. Cluster 3 exhibited the worst prognosis. A comparative analysis showed that nine expressed genes differed distinctly among all the clusters. Among these nine genes, elevated expression of CDK4 was strongly associated with positive prognosis. Furthermore, the expression of ANAPC11, ANAPC5, and ORC4 correlated with the advancement of LUSC pathological stages.ConclusionsGene expression profiles associated with the cell cycle across various LUSC subtypes were identified, highlighting that specific genes are related to prognosis and disease stages. Based on these results, new prognostic strategies, patient stratification, and targeted therapy trials have been conducted for LUSC.
Low‐grade follicular lymphoma with interferon regulatory factor‐4 rearrangement: Expanding the spectrum of interferon regulatory factor‐4‐rearranged lymphomas
Authors: Sakhdari Ali , Sabatini Peter J. B. , Geevar Tulasi , Zhang Tong , Delabie Jan M. A. 
Published: August 2024

AbstractIn recent years, the recognition of distinct lymphoma entities has expanded with advancements in molecular characterization. Large B‐cell Lymphoma with interferon regulatory factor‐4 (IRF4) rearrangement (LBCL‐IRF4‐R) is one such entity. We present a case of classic low‐grade follicular lymphoma with IRF4 rearrangement in a 50‐year‐old male, demonstrating an unusual immunophenotypic and genetic profile reminiscent of LBCL‐IRF4‐R. Molecular analysis revealed mutations in CREBBP, KMT2D, IRF4, and CARD11, with previously unreported variants identified in IRF4 and CREBBP. This case broadens the spectrum of B‐cell lymphomas associated with IRF4 rearrangement by demonstrating a small B‐cell lymphoma with this genetic feature.
Quantification of Cardiac Iron Overload at 3 T MRI in a Rabbit Model Utilizing ME–GRE T2* Sequence
Authors: Liang Linlin , Xiao Fangyan , Li Meicheng , Xu Fengming , Peng Fei , Luo Chaotian , Tang Cheng , Peng Peng 
Published: August 2024

BackgroundMyocardial iron overload can lead to myocardial dysfunction, muscle cell injury, and end‐stage heart failure. The enhanced signal‐to‐noise ratio and technical advancements have made 3 T magnetic resonance imaging (MRI) more accessible in clinical settings. However, 3 T assessments for early diagnosis of myocardial iron overload are scarce.PurposeTo evaluate the feasibility of myocardial iron quantification using 3 T MRI in a rabbit model of iron overload.Study TypeAnimal model.Animal ModelOverall, 40 male New Zealand white rabbits were categorized into control (N = 8; no treatment) and experimental (N = 32; weekly 200 mg/kg iron dextran injections) groups.Sequence3 T MRI with multi‐echo gradient echo (ME–GRE) T2* sequence.AssessmentEach week, two experimental rabbits were randomly selected for blood collection to determine serum iron (SI) levels; their tissue was harvested to assess myocardial and hepatic iron deposition.Statistical TestsSpearman's rank correlation tests were used to evaluate the correlations among R2*, cardiac iron concentration (CIC), liver iron concentration (LIC), total amount of iron injected, and SI levels. P ≤ 0.05 was considered statistically significant.ResultsThe myocardial T2* value in the experimental group was significantly lower than that of the control group. An excellent correlation was observed between R2* values and CIC (r = 0.854). CIC moderately correlated with LIC (r = 0.712) and the total amount of iron injected (r = 0.698). A strong correlation was observed between the total amount of iron injected and LIC (r = 0.866). SI levels poorly correlated with the total amount of iron injected (r = 0.205, P = 0.277) and LIC (r = 0.170, P = 0.370) but fairly correlated with CIC (r = 0.415, P = 0.022).Data ConclusionA 3 T MRI with an ME–GRE sequence may serve as a noninvasive method for evaluating cardiac iron content.Evidence LevelN/ATechnical EfficacyStage 1
Prerequisites for Clinical Implementation of Whole‐Heart 4D‐Flow MRI: A Delphi Analysis
Authors: van Schuppen Joost , van der Hulst Annelies E. , den Harder J. Michiel , Gottwald Lukas M , van Luijk Raschel D. , van den Noort Josien C. , Nelissen Jules L. , Coerkamp Casper F. , Boekholdt S. Matthijs , Groot Paul F.C. , Nederveen Aart , van Ooij Pim , Planken R. Nils ,   Delphi Panel Members
Published: August 2024

Whole‐heart 4D‐flow MRI is a valuable tool for advanced visualization and quantification of blood flow in cardiovascular imaging. Despite advantages over 2D‐phase‐contrast flow, clinical implementation remains only partially exploited due to many hurdles in all steps, from image acquisition, reconstruction, postprocessing and analysis, clinical embedment, reporting, legislation, and regulation to data storage. The intent of this manuscript was 1) to evaluate the extent of clinical implementation of whole‐heart 4D‐flow MRI, 2) to identify hurdles hampering clinical implementation, and 3) to reach consensus on requirements for clinical implementation of whole‐heart 4D‐flow MRI. This study is based on Delphi analysis. This study involves a panel of 18 experts in the field on whole‐heart 4D‐flow MRI. The experience with and opinions of experts (mean 13 years of experience, interquartile range 6) in the field were aggregated. This study showed that among experts in the cardiovascular field, whole‐heart 4D‐flow MRI is currently used for both clinical and research purposes. Overall, the panelists agreed that major hurdles currently hamper implementation and utilization. The sequence‐specific hurdles identified were long scan time and lack of standardization. Further hurdles included cumbersome and time‐consuming segmentation and postprocessing. The study concludes that implementation of whole‐heart 4D‐flow MRI in clinical routine is feasible, but the implementation process is complex and requires a dedicated, multidisciplinary team. A predefined plan, including risk assessment and technique validation, is essential. The reported consensus statements may guide further tool development and facilitate broader implementation and clinical use.Level of EvidenceNATechnical EfficacyStage 5
The Silver Lining of Workaholism: Its Impact on Employees' Creativity and Presenteeism Explained
Authors: Naseer Saima , Bouckenooghe Dave , Qazi Shadab , Syed Fauzia 
Published: August 2024

ABSTRACTIn this inquiry, we highlight that there is a silver lining to workaholism, relying on identity control theory as an explanatory framework. A parallel mediation model established that workaholism fosters employees' creativity but also triggers presenteeism through the mechanisms of thriving and flourishing. The model also shows that a proactive personality is a critical boundary condition that moderates the workaholism‐thriving and workaholism‐flourishing relationship. Two‐source multi‐wave temporally segregated data (n = 305) from the service sector in Islamabad (i.e., Pakistan) were used as a research design. Overall, this study contributes to the workaholism literature by unveiling two new pivotal mechanisms that depict a more balanced perspective to the dominant negative view of workaholics being obsessive‐compulsive addicts.
Caregiver burden and eating‐related guilt during dysphagia rehabilitation: A descriptive cross‐sectional time series study
Authors: Mori Hiroko , Nakane Ayako , Yokota Yuri , Tohara Haruka , Nakayama Takeo 
Published: August 2024

AbstractBackgroundCaregivers of patients with chronic dysphasia experience stress and guilt regarding their eating behaviors. Dysphagia rehabilitation, including minimal oral intake with tube feeding, may be vital for caregivers. This study investigated the effects of dysphagia rehabilitation on caregiver well‐being and attitudes toward eating assistance.MethodsThis cross‐sectional questionnaire study was conducted at two dental university hospitals on caregivers of homebound patients with dysphagia undergoing rehabilitation. Caregivers' experiences, with an emphasis on guilt and psychological status, were assessed using the Apathy Scale and Patient Health Questionnaire‐5 Depression Scale. Patients were evaluated at the time of the survey and rehabilitation commencement using the Barthel Index and Functional Oral Intake Scale (FOIS). Changes in FOIS scores and caregiver guilt were assessed using the Wilcoxon signed rank test and McNemar test, respectively. The impact of oral intake changes on caregiving motivation was assessed using the Fisher exact test.ResultsBetween August 2019 and January 2021, 55 of 100 targeted caregivers responded (median age=64.5 years). A significant difference in FOIS scores was found (median rehabilitation duration=9.7 months). Despite 25 pneumonia cases, 65% of the caregivers continued to encourage oral intake. Guilt decreased from 48% during peak dysphagia to 22% at survey time (odds ratio=0.2, 95% CI=0.04–0.70; P < 0.01). No association was found between caregiving motivation and improved oral intake.ConclusionSevere dysphagia impacted caregiver well‐being, indicating preferences for patients' oral intake. To support caregivers, healthcare professionals should explore and integrate new multidisciplinary approaches into dysphagia rehabilitation strategies.
From serials crisis to dollar crisis: The compelling evidence against APC‐based open access in sub‐Saharan Africa countries
Authors: Adegbilero‐Iwari Idowu 
Published: August 2024

Key points
The article processing charges (APC)‐based model of open access has constituted a major obstacle to achieving open access in developing countries.
High exchange rates of local currencies to the dollar make sustaining the APC open access model impractical.
Other approaches should be used to achieve equitable and inclusive open access.
Multi‐Object Silicon Photonic Spectrometer
Authors: Ding Zhihuan , Zhang Long , Liu Dajian , Song Lijia , Dai Daoxin 
Published: August 2024

AbstractA multi‐object silicon photonic spectrometer with N input ports is proposed and realized by integrating a multi‐channel passband optical filter (POF), a tunable narrow‐band optical filter as well as a calibration‐free N × 1 Mach–Zehnder switch (MZS) array. Here, the multi‐channel POF consisting of a multimode waveguide grating (MWG) and a mode (de)multiplexer is used to achieve a broadened working window and an enhanced dynamic range for the present spectrometer, while the narrow‐band optical filter is realized with a thermally‐tunable Euler micro‐ring resonator (EMR) for achieving a very high spectral resolution. The introduction of the N × 1 MZS enables the time‐division‐multiplexed (TDM) spectrum analysis for multiple objects. In this paper, a multi‐object silicon photonic spectrometer with 16 input ports is demonstrated with an on‐chip loss of less than 3 dB and inter‐channel crosstalk as low as −25 dB. This multi‐object spectrometer can be used to analyze the spectra of 16 objects one by one by setting the 16 × 1 MZS, the resolution is as high as 50 pm, and the working window is ≈84 nm.
Long‐Range Disorder MetaSurface Enabled High‐Performance One‐Shot Ultraviolet Full‐Stokes Polarimeter
Authors: Huang Shanshan , Xian Shilin , Peng Jialong , Yang Xiu , Du Jinglei , Hou Yidong 
Published: August 2024

AbstractThe rapidly‐developed nanophotonics enable the realization of highly‐precise, ultra‐compact full Stokes polarimeters. However, realizing large‐area well‐designed structures with complex chiral morphology and subwavelength size is still a challenge to the current micro/nano‐engineering technology. Here, one high‐performance, ultra‐compact, and one‐shot full‐Stokes polarimeters in the ultraviolet waveband for the first time based on the long‐range disorder chiral shells fabricated by the micro‐sphere lithography are experimentally demonstrated. This chiral–shell monolayer owns strong and distinct optical chirality and anisotropy between the shells in adjacent micro‐domains and thus leads to different photo‐electric responses to the incident polarized lights for the photodetectors placed underneath. Through employing the residual convolutional neural network to extract the Stokes parameter , a small detection averaged mean square error (MSE) of <0.5% from 316 nm to 410 nm is realized, and the minimum MSEs at 361 nm can reach recorded values of ≈0.02% (), 0.017% (), and 0.014% (). The influence of exposure time and pixel number, and the system stability are systematically investigated. This work brings new inspiration for the disorder structures based on Bottom‐Up methods, high‐performance polarimeters, and polarization imaging devices.