bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Adult White Matter Progenitor Cells Are Multipotent Neuroprogenitors Similar to Adult Hippocampal Progenitors
Authors: Lojewski Xenia , Hermann Andreas , Wegner Florian , Araúzo-Bravo Marcos J. , Hallmeyer-Elgner Susanne , Kirsch Matthias , Schwarz Johannes , Schöler Hans R. , Storch Alexander 
Published: February 2014

AbstractAdult neural progenitor cells (aNPC) are a potential autologous cell source for cell replacement in neurologic diseases or for cell-based gene therapy of neurometabolic diseases. Easy accessibility, long-term expandability, and detailed characterization of neural progenitor cell (NPC) properties are important requisites for their future translational/clinical applications. aNPC can be isolated from different regions of the adult human brain, including the accessible subcortical white matter (aNPCWM), but systematic studies comparing long-term expanded aNPCWM with aNPC from neurogenic brain regions are not available. Freshly isolated cells from subcortical white matter and hippocampus expressed oligodendrocyte progenitor cell markers such as A2B5, neuron-glial antigen 2 (NG2), and oligodendrocyte transcription factor 2 (OLIG2) in ∼20% of cells but no neural stem cell (NSC) markers such as CD133 (Prominin1), Nestin, SOX2, or PAX6. The epidermal growth factor receptor protein was expressed in 18% of aNPCWM and 7% of hippocampal aNPC (aNPCHIP), but only a small fraction of cells, 1 of 694 cells from white matter and 1 of 1,331 hippocampal cells, was able to generate neurospheres. Studies comparing subcortical aNPCWM with their hippocampal counterparts showed that both NPC types expressed mainly markers of glial origin such as NG2, A2B5, and OLIG2, and the NSC/NPC marker Nestin, but no pericyte markers. Both NPC types were able to produce neurons, astrocytes, and oligodendrocytes in amounts comparable to fetal NSC. Whole transcriptome analyses confirmed the strong similarity of aNPCWM to aNPCHIP. Our data show that aNPCWM are multipotent NPC with long-term expandability similar to NPC from hippocampus, making them a more easily accessible source for possible autologous NPC-based treatment strategies.
Mesenchymal Stem Cells With Modification of Junctional Adhesion Molecule A Induce Hair Formation
Authors: Wu Minjuan , Guo Xiaocan , Yang Ling , Wang Yue , Tang Ying , Yang Yongji , Liu Houqi 
Published: February 2014

Abstract
The junctional adhesion molecule A (JAM-A) has been shown to serve a crucial role in the proliferation, differentiation, and tube-like formation of epithelial cells during angiogenesis. The role of JAM-A in hair follicle (HF) regeneration has not yet been reported. In this study, we used human JAM-A-modified human mesenchymal stem cells (MSCs) to repair HF abnormalities in BALB/c nu/nu mice. The JAM-A gene and JAM-A short hairpin RNA were transfected into cultured human MSCs to generate the JAM-A overexpression MSCs (JAM-Aov MSCs) and JAM-A knockdown MSCs (JAM-Akd MSCs), respectively. These cells were injected intradermally into the skin of nude mice during the first telogen phase of the HF that occurs 21 days postnatally. We found that JAM-Aov MSCs migrated into the HF sheath and remodeled HF structure effectively. The HF abnormalities such as HF curve and HF zigzag were remodeled, and hair formation was improved 7 days following injection in both the JAM-Aov MSC and MSC groups, compared with the JAM-Akd MSC group or negative control group. Furthermore, the JAM-Aov MSC group showed enhanced hair formation in contrast to the MSC group, and the number of curved and zigzagged HFs was reduced by 80% (p &lt; .05). These results indicated that JAM-Aov MSCs improved hair formation in nude mice through HF structure remodeling.
La psychologie occidentale au contact de l’Inde : les enjeux d’une appropriation précipitée
Authors: Bédard Alexandre 
Published: February 2014

À l’heure actuelle, on observe en Occident la présence grandissante de professionnels en santé mentale et de chercheurs qui ont recours à des éléments théoriques et à des techniques issus des spiritualités indiennes comme, par exemple, le yoga et la méditation de la pleine conscience (ou mindfulness meditation). Bien que ces techniques soient souvent reçues favorablement par les Occidentaux, au point de devenir parfois très populaires, il s’avère pour l’instant difficile de cerner une position théorique claire sur ces sujets de la part de la psychologie et de bien identifier les sources sur lesquelles celle-ci s’appuierait. Le présent article vise à mieux comprendre la relation qui cherche à s’établir entre la psychologie occidentale et les spiritualités de l’Inde, non seulement à travers le jeu d’appropriations qui se déroule actuellement sous nos yeux, mais également à travers les contacts qui ont eu lieu entre ces deux traditions depuis la fin du xixe siècle.
As-built modeling of piping system from terrestrial laser-scanned point clouds using normal-based region growing
Authors: Kawashima Kazuaki , Kanai Satoshi , Date Hiroaki 
Published: February 2014

Abstract
Recently, renovations of plant equipment have been more frequent because of the shortened lifespans of the products, and as-built models from large-scale laser-scamied data is expected to streamline rebuilding processes. However, the laser-scanned data of an existing plant has an enormous amount ofpoints, captures inmcate objects, and includes a high noise level, so the manual reconstmction of a 3D model is very time-consuming and costly. Among plant equipment, piping systems account for the greatest proportion. Therefore, the purpose of this research was to propose an algorithm which could automatically recognize a piping system from the terrestrial laser- scanned data plant equipment. The straight pomon pipes, connecting parts, and connection relationship ofthe piping system can be recognized in this algorithm. Normal-based region growing and cylinder surface fitting can extract all possible locations ofpipes, including straight pipes, elbows, and junctions. Tracing the axes of a piping system enables the recognition of the positions of these elements and their connection relationship. Using only point clouds, the recognition algorithm can be performed in a fUlly automatic way. The algorithm was applied to large-scale scamied data of an oil rig and a chemical plant. Recognition rates of about 86%, 88%, and 71% were achieved straight pipes, elbows, andjunctions, respectively.
Novel computational approaches characterizing knee physiotherapy
Authors: Kim Wangdo , Veloso António P. , Araújo Duarte , Kohles Sean S. 
Published: February 2014

Abstract
A knee joint's longevity depends on the proper integration of structural components in an axial alignment. If just one of the components is abnormally off-axis, the biomechanical system fails, resulting in arthritis. The complexity of various failures in the knee joint has led orthopedic surgeons to select total knee replacement as a primary treatment. In many cases, this means sacrificing much of an otherwise normal joint. Here, we review novel computational approaches to describe knee physiotherapy by introducing a new dimension of foot loading to the knee axis alignment producing an improved functional status of the patient. New physiotherapeutic applications are then possible by aligning foot loading with the functional axis of the knee joint during the treatment of patients with osteoarthritis.
Vestibular Dysfunction in Patients With Chronic Pain or Underlying Neurologic Disorders
Authors: Gilbert John W. , Vogt Manuel , Windsor Robert E. , Mick Gregory E. , Richardson Gay B. , Storey Benjamin B. , Herder Stephanie L. , Ledford Susan , Abrams Dee A. , Theobald Mary Katherine , Cunningham Dana , Kelly Louise , Herring Kimberly V. , Maddox Michael L. 
Published: February 2014

AbstractContext:Individuals with vestibular dysfunction are at increased risk for falling. In addition, vestibular dysfunction is associated with chronic pain, which could present a serious public health concern as approximately 43% of US adults have chronic pain.Objective:To assess the incidence of vestibular dysfunction in patients receiving medication for chronic, noncancer pain or other underlying neurologic disorders and to determine associated follow-up therapeutic and diagnostic recommendations.Methods:The authors conducted a retrospective medical record review of consecutive patients who were treated in their private neuroscience practice with medications for chronic pain or underlying neurologic disorders in 2011. All patients underwent a series of tests using videonystagmography for the assessment of vestibular function. Test results and recommendations for therapy and additional testing were obtained.Results:Medical records of 124 patients (78 women, 46 men) were reviewed. Vestibular deficits were detected in 83 patients (66.9%). Patient ages ranged from 29 through 72 years, with a mean age of 50.7 years for women and 52.5 years for men. Physician-recommended therapy and follow-up testing were as follows: 32 patients (38.6%), neurologic examination and possible magnetic resonance (MR) imaging or computed tomography (CT) of the brain; 26 patients (31.3%), vestibular rehabilitation therapy only; 22 patients (26.5%), vestibular and related balance-function rehabilitation therapy, further neurologic examination, and possible MR imaging or CT; 2 patients (2.4%), balance-function rehabilitation therapy and specialized internal auditory canal high-magnification MR imaging or CT to assess for acoustic neuroma; and 1 patient (1.2%), specialized internal auditory canal high-magnification MR imaging or CT to evaluate for possible intracanalicular acoustic neuroma.Conclusion:Patients being treated with medications for chronic, noncancer pain or other underlying neurologic disorders may have a higher-than-average incidence of vestibular dysfunction. Baseline assessment and monitoring of the vestibular apparatus may be indicated for these patients.
The “Doctor of Osteopathy”: Expanding the Scope of Practice
Authors: Gevitz Norman 
Published: February 2014

AbstractThis article—the third in a 6-part series—examines the status of the DO degree in the first 3 decades of the 20th century. This time was an era when osteopathic practitioners established other colleges, developed state and national organizations, upgraded the length and breadth of curricula, and sought to secure licensure laws commensurate with their expanded education. During this period, osteopathic practitioners debated whether the DO degree was the most appropriate degree for their colleges to award or whether the MD degree alone or in conjunction with the DO degree better signified to lawmakers and the public their expanded academic training. At the end of this period it appeared likely that the DO degree would continue to be the sole designation by which osteopathic physicians would identify themselves in continuing their fight to obtain further legal rights and privileges.
Physicians' Role in Improving Adolescent Vaccination Rates
Authors: Craig Timothy J. 
Published: February 2014

Abstract
Over the course of human history, innumerable advances have been made to extend the length and quality of life. It would be difficult to debate the fact that vaccines have saved more lives than any other medical intervention in the past century. Sanitation, especially clean water, may have saved more lives than any other intervention, but sanitation has been mainly in the hands of engineers. Physicians and other health care practitioners, with the help of educators, are responsible for saving millions of lives by vaccinating patients, perhaps as many as 6 million per year.1
The mediating role of hostile attribution bias in social exclusion affecting aggressive behavior
Authors: Quan Fangying , Zhou Jiayu , Gou Yan , Gui Mengqiong , Wang Lu , Zhang Shuyue 
Published: July 2024

AbstractAggression is one of the public social issues affecting campus harmony and stability, and social exclusion is an important interpersonal contextual factor among many factors affecting aggression. However, studies examining the influence of social exclusion on aggression and its mediating mechanism are not systematic enough. Based on the general aggression model (GAM), we intend to explore the role of hostile attribution bias (HAB) in both trait and state levels of social exclusion, which leads to aggression through a combination of questionnaire and experimental methods. Study 1 surveyed 388 current high school students (Mage = 16.09, SD = 1.01) and found that HAB mediates the relationship between long‐term social exclusion (trait level) and aggression tendency. Study 2 experimented with 181 high school students (Mage = 16.95, SD = 1.13) to examine whether short‐term social exclusion (state level) after initiating the Cyberball paradigm could still influence aggressive behavior through the mediating role of HAB. Results found that the mediating role of HAB still holds. The findings of the study further enrich the GAM and have important implications for a more targeted approach to aggression prevention and intervention.
Near Room Temperature Solvothermal Growth of Ferroelectric CsPbBr3 Nanoplatelets with Ultralow Dark Current
Authors: Anilkumar Gokul M. , Bhakar Monika , Taneja Chetna , Hwang Sooyeon , Kumar G. V. Pavan , Sheet Goutam , Rahman Atikur 
Published: July 2024

AbstractCsPbBr3 exhibits outstanding optoelectronic properties and thermal stability, making it a coveted material for detectors, light‐emitting diodes, and solar cells. Despite observations of ferroelectricity in CsPbBr3 quantum dots, synthesizing bulk ferroelectric CsPbBr3 crystals has remained elusive, hindering its potential in next‐generation optoelectronic devices like optical switches and ferroelectric photovoltaics. Here, a breakthrough is reported: a novel solvothermal technique enabling the growth of ferroelectric CsPbBr3 nanoplatelets with lateral dimensions in the tens of micrometers. This represents a significant step toward achieving large‐area ferroelectric CsPbBr3 crystals. Unlike traditional methods, this approach allows for growth and crystallization of CsPbBr3 in alcohol solutions by enhancing precursor solubility. This study confirms the ferroelectric nature of these nanoplatelets using second harmonic generation, electrical characterizations, and piezoresponse force microscopy. This work paves the way for utilizing ferroelectric CsPbBr3 in novel optoelectronic devices, significantly expanding the potential of this material and opening doors for further exploration in this exciting field.
Engineered Regenerative Isolated Peripheral Nerve Interface for Targeted Reinnervation
Authors: Kwon Jinju , Eom Seongsu , Kong Jeong Sik , Cho Dong‐Woo , Kim Dong Sung , Kim Junesun 
Published: July 2024

AbstractA regenerative peripheral nerve interface (RPNI) offers a therapeutic solution for nerve injury through reconstruction of the target muscle. However, implanting a transected peripheral nerve into an autologous skeletal muscle graft in RPNI causes donor‐site morbidity, highlighting the need for tissue‐engineered skeletal muscle constructs. Here, an engineered regenerative isolated peripheral nerve interface (eRIPEN) is developed using 3D skeletal cell printing combined with direct electrospinning to create a nanofiber membrane envelop for host nerve implantation. In this in vivo study, after over 8 months of RPNI surgery, the eRIPEN exhibits a minimum Feret diameter of 15–20 µm with a cross‐sectional area of 100–500 µm2, representing the largest distribution of myofibers. Furthermore, neuromuscular junction formation and muscle contraction with a force of ≈28 N are observed. Notably, the decreased hypersensitivity to mechanical/thermal stimuli and an improved tibial functional index from −77 to −56 are found in the eRIPEN group. The present novel concept of eRIPEN paves the way for the utilization and application of tissue‐engineered constructs in RPNI, ultimately realizing neuroprosthesis control through synaptic connections.
Achieving Ultrasound‐Excited Emission with Organic Mechanoluminescent Materials
Authors: Chang Kai , Gu Juqing , Yuan Likai , Guo Jianfeng , Wu Xiangxi , Fan Yuanyuan , Liao Qiuyan , Ye Guigui , Li Qianqian , Li Zhen 
Published: July 2024

AbstractUnlike traditional photoluminescence (PL), mechanoluminescence (ML) achieved under mechanical excitation demonstrates unique characteristics such as high penetrability, spatial resolution, and signal‐to‐background ratio (SBR) for bioimaging applications. However, bioimaging with organic mechanoluminescent materials remains challenging because of the shallow penetration depth of ML with short emission wavelengths and the absence of a suitable mechanical force to generate ML in vivo. To resolve these issues, the present paper reports the achievement of ultrasound (US)‐excited fluorescence and phosphorescence from purely organic luminogens for the first time with emission wavelengths extending to the red/NIR region, with the penetrability of the US‐excited emission being considerably higher than that of PL. Consequently, US‐excited subcutaneous phosphorescence imaging can be achieved using a mechanoluminescent‐luminogen‐based capsule device with a quantified intensity of 9.15 ± 1.32 × 104 p s−1 cm−2 sr−1 and an SBR of 24. Moreover, the US‐excited emission can be adequately tuned using the packing modes of the conjugated skeletons, dipole orientation of mechanoluminescent luminogens, and strength and direction of intermolecular interactions. Overall, this study innovatively expands the kind of excitation sources and the emission wavelengths of organic mechanoluminescent materials, paving the way for practical biological applications based on US‐excited emission.
Catalytic Asymmetric Cycloadditions of Cyclic Sulfamidate Imines: Straightforward Access to Chiral N‐Heterocycles
Authors: Park Jong‐Un , Hyun Kim Ju 
Published: July 2024

AbstractChiral N‐heterocyclic compounds are key structures in natural compounds and pharmaceuticals, and they serve as essential building blocks of functional materials. Catalytic asymmetric cycloaddition reactions represent one of the most efficient synthetic strategies for constructing optically active heterocycles. Cyclic sulfamidate imines have recently come to be extensively studied and widely utilized in both organocatalytic and transition metal‐catalyzed asymmetric cycloadditions, where they have been shown to provide various N‐fused‐heterocycles and spiro‐cycles exhibiting high efficiencies with excellent stereoselectivities. This review highlights recent advancements in catalytic asymmetric cycloadditions of cyclic sulfamidate imines for the stereoselective synthesis of biologically active sulfamidate‐containing heterocycles since 2012 while focusing on the diverse reactivities of cyclic sulfamidate imines and the mechanisms of chiral induction in catalysis.
PROTAC‐Mediated HDAC7 Protein Degradation Unveils Its Deacetylase‐Independent Proinflammatory Function in Macrophages
Authors: Kadier Kailibinuer , Niu Tian , Ding Baoli , Chen Boya , Qi Xuxin , Chen Danni , Cheng Xirui , Fang Yizheng , Zhou Jiahao , Zhao Wenyi , Liu Zeqi , Yuan Yi , Zhou Zhan , Dong Xiaowu , Yang Bo , He Qiaojun , Cao Ji , Jiang Li , Zhu Cheng‐Liang 
Published: July 2024

AbstractClass IIa histone deacetylases (Class IIa HDACs) play critical roles in regulating essential cellular metabolism and inflammatory pathways. However, dissecting the specific roles of each class IIa HDAC isoform is hindered by the pan‐inhibitory effect of current inhibitors and a lack of tools to probe their functions beyond epigenetic regulation. In this study, a novel PROTAC‐based compound B4 is developed, which selectively targets and degrades HDAC7, resulting in the effective attenuation of a specific set of proinflammatory cytokines in both lipopolysaccharide (LPS)‐stimulated macrophages and a mouse model. By employing B4 as a molecular probe, evidence is found for a previously explored role of HDAC7 that surpasses its deacetylase function, suggesting broader implications in inflammatory processes. Mechanistic investigations reveal the critical involvement of HDAC7 in the Toll‐like receptor 4 (TLR4) signaling pathway by directly interacting with the TNF receptor‐associated factor 6 and TGFβ‐activated kinase 1 (TRAF6‐TAK1) complex, thereby initiating the activation of the downstream mitogen‐activated protein kinase/nuclear factor‐κB (MAPK/NF‐κB) signaling cascade and subsequent gene transcription. This study expands the insight into HDAC7's role within intricate inflammatory networks and highlights its therapeutic potential as a novel target for anti‐inflammatory treatments.
Primary and Orthotopic Murine Models of Nasopharyngeal Carcinoma Reveal Molecular Mechanisms Underlying its Malignant Progression
Authors: Wan Xudong , Liu Yuantao , Peng Yiman , Wang Jian , Yan Shu‐mei , Zhang Lu , Wu Wanchun , Zhao Lei , Chen Xuelan , Ren Kexin , Long Haicheng , Luo Yiling , Yan Qin , Zhang Lele , Lei Dengzhi , Liu Pengpeng , Li Shujun , Liu Lihui , Guo Linjie , Du Jiajia , Zhang Mengsha , Dai Siqi , Yang Yi , Liu Hongyu , Chen Nianyong , Bei Jinxin , Feng Lin , Liu Yu , Zeng Mu‐sheng , Chen Chong , Zhong Qian 
Published: July 2024

AbstractNasopharyngeal carcinoma (NPC), a squamous cell carcinoma originating in the nasopharynx, is a leading malignancy in south China and other south and east Asia areas. It is frequently associated with Epstein‐Barr virus (EBV) infection, while there are also some NPC patients without EBV infection. Here, it is shown that the EBV+ (EBV positive) and EBV‐ (EBV negative) NPCs contain both shared and distinct genetic abnormalities, among the latter are increased mutations in TP53. To investigate the functional roles of NPC‐associated genetic alterations, primary, orthotopic, and genetically defined NPC models were developed in mice, a key tool missed in the field. These models, initiated with gene‐edited organoids of normal nasopharyngeal epithelium, faithfully recapitulated the pathological features of human disease. With these models, it is found that Trp53 and Cdkn2a deficiency are crucial for NPC initiation and progression. And latent membrane protein1 (LMP1), an EBV‐coding oncoprotein, significantly promoted the distal metastasis. Further, loss of TGFBR2, which is frequently disrupted both in EBV‐ and EBV+ NPCs, dramatically accelerated the progression and lung metastasis of NPC probably by altering tumor microenvironment. Taken together, this work establishes a platform to dissect the genetic mechanisms underlying NPC pathogenesis and might be of value for future translational studies.