bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Palladium‐Catalyzed C—N Cross‐Coupling of N′‐Monosubstituted Sulfondiimines with Aryl Bromides.
Authors: Candy Mathieu , Bohmann Rebekka Anna , Bolm Carsten 
Published: April 2013

AbstractThe present general method for the N‐arylation of sulfondiimines with aryl bromides provides access to novel functionalized N,N′‐disubstituted products.
ChemInform Abstract: A Practical Protocol for the Hiyama Cross‐Coupling Reaction Catalyzed by Palladium on Carbon.
Authors: Monguchi Yasunari , Yanase Takayoshi , Mori Shigeki , Sajiki Hironao 
Published: April 2013

AbstractOptimized reaction conditions including Pd‐C as the catalyst and water as a promotor are developed for the Hiyama cross‐coupling reaction of aryl halides with arylsilanes to synthesize biaryls (III) (21 examples).
ChemInform Abstract: Asymmetric Broensted Acid Catalyzed Cycloadditions — Efficient Enantioselective Synthesis of Pyrazolidines, Pyrazolines, and 1,3‐Diamines from N‐Acyl Hydrazones and Alkenes.
Authors: Rueping Magnus , Maji Modhu Sudan , Kuecuek Hatice Baspinar , Atodiresei Iuliana 
Published: April 2013

AbstractChiral pyrazolines and their derivatives are a common motif in biologically active compounds.
ChemInform Abstract: Facile Regioselective Synthesis of 5‐Hydroxy‐4,5‐dihydroisoxazoles from Acetylenic Ketones.
Authors: Xie Meihua , Li Ming , Liu Changqing , Zhang Jitan , Feng Chengyou 
Published: April 2013

AbstractThe title compounds (III) are conveniently obtained by tandem conjugate addition‐cyclization reaction of acetylenic ketones and hydroxylamine hydrochloride.
ChemInform Abstract: Synthesis and Pharmacological Evaluation of 4‐Iminothiazolidinones for Inhibition of PI3 Kinase.
Authors: Pinson Jo‐Anne , Schmidt‐Kittler Oleg , Frazzetto Mark , Zheng Zhaohua , Jennings Ian G. , Kinzler Kenneth W. , Vogelstein Bert , Chalmers David K. , Thompson Philip E. 
Published: April 2013

AbstractA library of 4‐iminothiazolidinones (28 examples) is synthesized by multiple pathways and their enzyme inhibitor activities are tested.
ChemInform Abstract: Reaction of 1,2,3‐Oxadiazole 3‐Oxides.
Authors: Sugihara Takumichi , Murakawa Akira , Sawanaka Chiemi , Seki Megumi , Iio Natsuki , Iizuka Ayano , Oohora Takuya , Honzawa Shinobu 
Published: April 2013

AbstractSodium borohydride selectively reduces the carbon‐carbon double bond in oxadiazole oxides (I).
ChemInform Abstract: Synthesis and Photophysical Properties of New Highly Conjugated Bispyrylium Compounds.
Authors: Gong Wei‐Tao , Qian Xiao‐min , Wang Fu‐Rui , Lin Yuan , Ning Gui‐Ling 
Published: April 2013

AbstractThe title compounds (V) are obtained by Knoevenagel reaction between α‐methyl‐substituted pyrylium salt (III) and aromatic dicarboxaldehydes (IV).
ChemInform Abstract: An Efficient, One‐Pot Regioselective Synthesis of Highly Functionalized Chromen‐5‐ones and Pyrano[3,2‐c]chromen‐5‐ones via a Tandem Knoevenagel—Michael—Cyclization Sequence.
Authors: Kamalraja Jayabal , Muralidharan Doraiswamy , Perumal Paramasivan Thirumalai 
Published: April 2013

AbstractThe highly regioselective and chemoselective approach renders possible the formation of 2 new C—C bonds and 1 new C—O bond as well as the creation of one stereocenter in a single operation.
ChemInform Abstract: Stereoselective Cascade Double‐Annulations Provide Diversely Ring‐Fused Tetracyclic Benzopyrones.
Authors: Baskar Baburaj , Wittstein Kathrin , Sankar Muthukumar G. , Khedkar Vivek , Schuermann Markus , Kumar Kamal 
Published: April 2013

AbstractThe presented new annulation strategy provides stereoselective access to complex tetracyclic benzopyrones.
ChemInform Abstract: Synthesis of Nuevamine Aza‐Analogues by a Sequence: I‐MCR—Aza‐Diels—Alder—Pictet—Spengler.
Authors: Islas‐Jacome Alejandro , Cardenas‐Galindo Luis E. , Jerezano Alberto V. , Tamariz Joaquin , Gonzalez‐Zamora Eduardo , Gamez‐Montano Rocio 
Published: April 2013

AbstractA one‐pot procedure including Ugi three‐component reaction, aza‐Diels—Alder cycloaddition and aromatization provides key intermediates (V).
ChemInform Abstract: Design, Synthesis and Antimicrobial Evaluation of Novel 1‐Benzyl 2‐Butyl‐4‐chloroimidazole Embodied 4‐Azafluorenones via Molecular Hybridization Approach.
Authors: Addla Dinesh , Bhima Bhima , Sridhar Balasubramanian , Devi Anjana , Kantevari Srinivas 
Published: April 2013

AbstractThe title compounds (IV) (15 examples) are obtained in very good yields via one‐pot condensation of 4‐chloroimidazole‐5‐carboxaldehyde (I), 1,3‐indanedione, various aryl/heteroaryl methyl ketones, and ammonium acetate.
ChemInform Abstract: Synthesis and Structure of Novel 4‐Arylamino‐2‐phenyl‐6‐substituted‐quinazoline.
Authors: Xing Zhi‐Yong , Fu Ying , Ye Fei 
Published: April 2013

AbstractNovel quinazolines (II) are obtained unexpectedly via photocyclization of substituted thioureas (I) under basic conditions.
ChemInform Abstract: Cerous Methanesulfonate Catalyzed Facile Synthesis of 2‐Substituted‐2,3‐dihydro‐4(1h)‐quinazolinones by Grinding Technique.
Authors: Wang Min , Gao Jingjing , Song Zhiguo , Wang Lei 
Published: April 2013

AbstractVirtually the presented quinazolinone synthesis consists of a two‐step procedure starting with a grinding phase followed by conventional heating.
ChemInform Abstract: Nickel‐Catalyzed Borylation of Aryl Halides with 4,4,6‐Trimethyl‐1,3,2‐dioxaborinane.
Authors: Murata Miki , Sogabe Yosuke , Namikoshi Takeshi , Watanabe Shinji 
Published: April 2013

AbstractElectron‐donating or ortho substituted aromatic bromides give low yields compared to the corresponding iodides (IIa) and (IId).
ChemInform Abstract: Microwave‐Assisted Regioselective Benzylation: An Access to Glycal Derivatives with a Free Hydroxyl Group at C4.
Authors: Bieg Tadeusz , Kral Katarzyna , Paszkowska Jadwiga , Szeja Wieslaw , Wandzik Ilona 
Published: April 2013

AbstractD‐Glucal, D‐galactal (I), and their 6‐O‐protected derivatives, e.g. (IV), are benzylated in a two‐step sequence.
ChemInform Abstract: Formal Synthesis of Hapalindole O and Synthetic Efforts Towards Hapalindole K and Ambiguine A.
Authors: Rafferty Ryan J. , Williams Robert M. 
Published: April 2013

AbstractThe tin‐mediated coupling of indoles (I) with Tms‐enol ether (II) followed by HCl‐promoted ring closure and subsequent oxidation of intermediate alcohols leads to ketones (III), which are potential intermediates for the synthesis of hapalindole K (IVa) and ambiguine A (IVb).
ChemInform Abstract: First Total Synthesis and Absolute Configuration of Keramamine C.
Authors: Ishiyama Haruaki , Mori Yuta , Matsumoto Takashi , Kobayashi Jun'ichi 
Published: April 2013

AbstractThe asymmetric total synthesis of keramamine C (I), a tetrahydro‐β‐carboline alkaloid from the marine sponge Amphimedon sp., is accomplished in seven steps and 3% overall yield from tryptamine and phthalimidepropane acid via Bischler‐Napieralski reaction and the Noyori catalytic asymmetric hydrogen‐transfer reaction as the key steps.
ChemInform Abstract: Synthesis of Calycotomine and N‐Methylcalycotomine Using a Petasis Reaction — Pomeranz—Fritsch—Bobbitt Cyclization Sequence.
Authors: Chrzanowska Maria , Grajewska Agnieszka , Rozwadowska Maria D. 
Published: April 2013

AbstractA new synthetic procedure is given for the two title alkaloids calycotomine (VI) and N‐methylcalycotomine (IX).
ChemInform Abstract: Isoaurones from the Stem of Cassia siamea and Their anti‐Tobacco Mosaic Virus (anti‐TMV) Activity.
Authors: Gao Xue‐mei , Shu Li‐dan , Yang Li‐ying , Shen Yan‐qiong , Cui Ming‐zhu , Li Xue‐mei , Hu Qiu‐fen 
Published: April 2013

AbstractThe isolation and structure elucidation of siamaurone A (I) and B (II) are reported.
ChemInform Abstract: Are Alkyne Reductions Chemo‐, Regio‐, and Stereoselective Enough To Provide Pure (Z)‐Olefins in Polyfunctionalized Bioactive Molecules?
Authors: Oger Camille , Balas Laurence , Durand Thierry , Galano Jean‐Marie 
Published: April 2013

AbstractReview: 546 refs.
Cumulative incidence of cancer after solid organ transplantation
Authors: Hall Erin C. , Pfeiffer Ruth M. , Segev Dorry L. , Engels Eric A. 
Published: April 2013

BACKGROUNDSolid organ transplantation recipients have elevated cancer incidence. Estimates of absolute cancer risk after transplantation can inform prevention and screening.METHODSThe Transplant Cancer Match Study links the US transplantation registry with 14 state/regional cancer registries. The authors used nonparametric competing risk methods to estimate the cumulative incidence of cancer after transplantation for 2 periods (1987‐1999 and 2000‐2008). For recipients from 2000 to 2008, the 5‐year cumulative incidence, stratified by organ, sex, and age at transplantation, was estimated for 6 preventable or screen‐detectable cancers. For comparison, the 5‐year cumulative incidence was calculated for the same cancers in the general population at representative ages using Surveillance, Epidemiology, and End Results data.RESULTSAmong 164,156 recipients, 8520 incident cancers were identified. The absolute cancer risk was slightly higher for recipients during the period from 2000 to 2008 than during the period from 1987 to 1999 (5‐year cumulative incidence: 4.4% vs 4.2%; P = .006); this difference arose from the decreasing risk of competing events (5‐year cumulative incidence of death, graft failure, or retransplantation: 26.6% vs 31.9%; P < .001). From 2000 to 2008, the 5‐year cumulative incidence of non‐Hodgkin lymphoma was highest at extremes of age, especially in thoracic organ recipients (ages 0‐34 years: range, 1.74%‐3.28%; aged >50 years; range, 0.36%‐2.22%). For recipients aged >50 years, the 5‐year cumulative incidence was higher for colorectal cancer (range, 0.33%‐1.94%) than for the general population at the recommended screening age (aged 50 years: range, 0.25%‐0.33%). For recipients aged >50 years, the 5‐year cumulative incidence was high for lung cancer among thoracic organ recipients (range, 1.16%‐3.87%) and for kidney cancer among kidney recipients (range, 0.53%‐0.84%). The 5‐year cumulative incidence for prostate cancer and breast cancer was similar or lower in transplantation recipients than at the recommended ages of screening in the general population.CONCLUSIONSSubgroups of transplantation recipients have a high absolute risk of some cancers and may benefit from targeted prevention or screening. Cancer 2013;119:2300–2308. © 2013 American Cancer Society.
Radio versus backhaul bottlenecks: an integrated quality of service provisioning approach for small cell gateways
Authors: Skianis Charalabos 
Published: April 2013

SUMMARYSmall cell traffic is expected to experience a continuous increase during the upcoming years, and thus, backhauling challenges should be timely addressed. Regardless the fact that radio resource management continues to be a major research problem in coexisting heterogeneous wireless networks, a mentality shift is observed in the research community towards dealing with wired backhaul bottleneck situations, too. Hence, specific small cell network deployments such as the one considered in this paper have to adopt an integrated quality of service provisioning approach. A femtocell utilizing an existing internet protocol (IP) infrastructure has usually to share the backhaul capacity with several IP networks. As these networks do not provide an efficient admission control process, the capacity allocated to the femtocell can fluctuate unpredictably over time. As a remedy, we propose a scheme for small cells' efficient integration (SCEI) in the IP infrastructure. SCEI is able to manage the total incoming traffic load and continuously adjust the distribution of the backhaul capacity among the existing networks. Simulation results show that SCEI provides significantly higher utilization of the backhaul capacity and more resilience regarding quality‐of‐service‐related metrics in overload state situations compared with state‐of‐the‐art hybrid partitioning techniques. Finally, this work also provides hints on ways that SCEI concepts can be applicable in more future Internet and small cell network deployment variants. Copyright © 2013 John Wiley & Sons, Ltd.
Chalcogen–Nitrogen Secondary Bonding Interactions in the Gas Phase – Spectrometric Detection of Ionized Benzo‐2,1,3‐telluradiazole Dimers
Authors: Cozzolino Anthony F. , Dimopoulos‐Italiano Gina , Lee Lucia Myongwon , Vargas‐Baca Ignacio 
Published: April 2013

AbstractThe mass spectra of benzo‐2,1,3‐chalcogenadiazoles, acquired from the equilibrium conditions of the UV‐laser desorption/ionization plume, contain isotopic patterns that are characteristic of protonated and ionized dimers. Dispersion‐corrected DFT modeling shows that the most stable structures of these dimers feature the supramolecular four‐membered Te2N2 ring, which is pervasive in the crystal structures of these compounds. These observations provide the first evidence of the persistence of Te–N supramolecular association in the gas phase.
Synthesis and Characterization of Oxadisilole‐Fused 1H‐Benzo[f]indazoles and 1H‐Naphtho[2,3‐f]indazoles
Authors: Zhang Yajuan , Ma Xuyan , Chen Yali , Chen Xuanming , Guo Lei , Cao Weiguo , Chen Jie , Wong Man Shing 
Published: April 2013

AbstractOxadisilole‐fused 1H‐benzo[f]‐ and 1H‐naphtho[2,3‐f]indazoles have been synthesized by the 1,3‐dipolar cycloaddition reactions of benzo‐ or naphtho‐oxabicycloalkenes with nitrile imines generated in situ from N‐arylhydrazonoyl chlorides followed by deoxygenation and aromatization. The photophysical, redox and thermal properties of these compounds have been characterized. Some of the indazoles show potential as deep‐blue emitters for OLED applications as a result of their high fluorescence quantum yields and good thermal stabilities.
Three‐dimensional modeling and simulation of DNA hybridization kinetics and mass transport as functions of temperature in a microfluidic channel
Authors: Schares Elizabeth S. , Edwards Thayne L. , Moorman Matthew W. , Polsky Ronen , Brozik Susan M. , Manginell Ronald P. 
Published: April 2013

A 3D finite element model was developed to optimize the kinetics and mass transfer characteristics of low concentration, 18 bp ssDNA targets in bulk media solution, to 18 bp complimentary oligonucleotide probes immobilized on electrochemical detection electrodes positioned along the length of a microfluidic channel. Conditions considered in the model were fluid flow rate, diffusion time, DNA melting temperature, number of matching base pairs, and temperature of the fluid in the channel. System optimization was based on maximizing the uniformity and surface concentration of the specifically bound hybridized DNA, minimizing waste volume generation and the hybridization time. With the coupled simulation method used, the total experiment time was reduced from 150 to 60 min and the simulated results were consistent with experimental results found in the literature. A stopped flow procedure was investigated as a means to improve hybridization. This procedure can not only improve uniformity and capture efficiency, and reduce waste, but can also decrease overall signal intensity relative to continuous flow operation. Finally, the use of temperature in reducing mismatched hybridization and improving duplex stability was also successfully modeled and simulated.
Shake table testing and numerical simulation of a self‐centering energy dissipative braced frame
Authors: Erochko Jeffrey , Christopoulos Constantin , Tremblay Robert , Kim Hyung‐Joon 
Published: April 2013

SUMMARYThe self‐centering energy dissipative (SCED) brace is a new steel bracing member that provides both damping to the structure and a re‐centering capability. The goal of this study was to confirm the behavior of SCED braces within complete structural systems and to confirm the ability to model these systems with both a state‐of‐the‐art computer model as well as a simplified model that would be useful to practicing engineers. To these ends, a three‐story SCED‐braced frame was designed and constructed for testing on a shake table. Two concurrent computer models of the entire frame were constructed: one using the opensees nonlinear dynamic modeling software, and a simplified model using the commercial structural analysis software sap2000. The frame specimen was subjected to 12 significant earthquakes without any adjustment or modification between the tests. The SCED braces prevented residual drifts in the frame, as designed, and did not show any significant degradation due to wear. Both numerical models were able to predict the drifts, story shears, and column forces well. Peak story accelerations were overestimated in the models; this effect was found to be caused by the absence of transitions at stiffness changes in the hysteretic model of the braces. Copyright © 2013 John Wiley & Sons, Ltd.
Making Medical Decisions in Dependence of Genetic Background: Estimation of the Utility of DNA Testing in Clinical, Pharmaco‐Epidemiological or Genetic Studies
Authors: Nguyen Thuy Trang , Schäfer Helmut , Timmesfeld Nina 
Published: April 2013

ABSTRACTAn index measuring the utility of testing a DNA marker before deciding between two alternative treatments is proposed which can be estimated from pharmaco‐epidemiological case‐control or cohort studies. In the case‐control design, external estimates of the prevalence of the disease and of the frequency of the genetic risk variant are required for estimating the utility index. Formulas for point and interval estimates are derived. Empirical coverage probabilities of the confidence intervals were estimated under different scenarios of disease prevalence, prevalence of drug use, and population frequency of the genetic variant. To illustrate our method, we re‐analyse pharmaco‐epidemiological case‐control data on oral contraceptive intake and venous thrombosis in carriers and non‐carriers of the factor V Leiden mutation. We also re‐analyse cross‐sectional data from the Framingham study on a gene‐diet interaction between an APOA2 polymorphism and high saturated fat intake on obesity. We conclude that the utility index may be helpful to evaluate and appraise the potential clinical and public health relevance of gene‐environment interaction effects detected in genomic and candidate gene association studies and may be a valuable decision support for designing prospective studies on the clinical utility.
MULTILATERAL CONTRACTING AND PREVENTION
Authors: Pope Brandon , Deshmukh Abhijit , Johnson Andrew , Rohack James 
Published: April 2013

ABSTRACTIncentives created through contracts can be used as a means of decentralized control in healthcare systems to ensure more efficient healthcare. In this paper, we consider an insurer contracting with a consumer and a provider. We focus on the trade‐off between ex ante moral hazard and insurance, and consider both consumer and provider incentives in the insurer's contracting problem in the presence of unobservable preventive efforts. We study two cases of provider efforts: those that complement consumer efforts and those that substitute for consumer efforts. In the first case, our results show that the provider must have greater incentives when the consumer is healthy to induce effort and that inducing provider effort allows an insurer to offer a more complete insurance contract relative to the bilateral benchmark. In the second case, we state conditions under which these conclusions continue to hold. On the basis of our findings, we discuss the implications and challenges of multilateral contracting in practice. Copyright © 2013 John Wiley & Sons, Ltd.
Factors affecting swallow outcome following treatment for advanced oral and oropharyngeal malignancies
Authors: Kalavrezos Nicholas , Cotrufo Stefano , Govender Roganie , Rogers Pauline , Pirgousis Phil , Balasundram Sathesh , Lalabekyan Bagrat , Liew Colin 
Published: April 2013

BackgroundTreatment for tumors of the oral cavity and the oropharynx disrupts normal swallow function. The ability for oral diet postoperatively varies and may be influenced by surgery and patient‐related factors.MethodsIn all, 114 patients treated with surgery with and without chemoradiotherapy for advanced oral/oropharyngeal cancer were recruited. Clinicopathologic tumor parameters and reconstruction modalities were recorded. Swallow function was determined by oral intake, using the Functional Oral Intake Scale (FOIS) pretreatment and posttreatment.ResultsThe median time to first attaining swallow function was 14 days. Patients were less likely to attain tube independence within 1 year of surgery if they received radiotherapy or had a low FOIS score preoperatively. Patients' time to first attaining swallow function postsurgery was inversely related to the FOIS score presurgery.ConclusionsSwallow function recovery postsurgery is better in patients with higher FOIS presurgery, smaller tumors, and no requirement for radiotherapy. © 2013 Wiley Periodicals, Inc. Head Neck 36: 47–54, 2014
Neck spasm after chemoradiotherapy for head and neck cancer: Natural history and dosimetric correlates
Authors: Hunter Klaudia U. , Worden Francis , Bradford Carol , Prince Mark , McLean Scott , Wolf Gregory , Chepeha Douglas B. , Eisbruch Avraham 
Published: April 2013

BackgroundLittle is known about the determinants of postradiation neck spasms in patients with head and neck cancer.MethodsPatients with head and neck cancer treated with radiation therapy (RT) from 2004 to 2010 who experienced neck spasms werereviewed. Radiation doses were generated for their sternocleidomastoid (SCM) muscles bilaterally. Unaffected SCMs were used as controls.ResultsThirty‐four patients reported neck spasms. Thirty had received definitive chemoradiation, and 4 had RT alone. Seven also had an ipsilateral neck dissection. Median time to onset was 23 months (range, 6–67 months). There were significantly higher radiation doses to the affected SCMs with a median of the mean dose to the affected and unaffected SCM of 62.3 Gy (range, 29–71 Gy) and 53.7 Gy (range, 27–65 Gy), respectively (p < .0001). Other dosimetric variables were also statistically significant but were highly correlated with the mean SCM dose. Neck dissection did not affect our results.ConclusionNeck spasms after chemotherapy intensity‐modulated radiation therapy (IMRT) shows a strong dose–response relationship. © 2013 Wiley Periodicals, Inc. Head Neck 36: 176–180, 2014
Regional vulnerability of hippocampal subfields and memory deficits in Parkinson's disease
Authors: Pereira Joana B. , Junqué Carme , Bartrés‐Faz David , Ramírez‐Ruiz Blanca , Marti Maria‐Jose , Tolosa Eduardo 
Published: April 2013

ABSTRACTNeuropathological studies show the hippocampus is affected in Parkinson's disease (PD), with the second subfield of the cornu armonis (CA2) being the most involved. Our aims were to assess in vivo volumes of different hippocampal subfields in patients with PD with and without visual hallucinations using MRI and test their association with verbal learning and long‐term recall. A total of 18 nondemented PD patients, 18 nondemented PD patients with visual hallucinations and 18 neurologically unimpaired elderly controls matched by age and gender were enrolled in this study. We assessed the volumes of seven hippocampal subfields on MRI, including the cornu armonis (CA) sectors, subiculum, presubiculum, and the dentate gyrus (DG) using a novel technique that enables automated volumetry. The CA2‐3 and CA4‐DG subfields were significantly smaller in both groups of patients, while the subiculum was only reduced in PD patients with visual hallucinations, compared to controls. Significant correlations were found between learning performance and CA2‐3 as well as CA4‐DG volumes in the whole patient sample. These data show there is regional atrophy of specific hippocampal subfields in PD, which is more severe and further extends to the subiculum in patients with visual hallucinations. Our findings indicate that learning deficits are associated with volume loss in subfields that act as input regions in the hippocampal circuit, suggesting that degeneration in these regions could be responsible for cognitive dysfunction in PD. © 2013 Wiley Periodicals, Inc.