bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural Basis of Agitated Behaviors in Patients with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease
Authors: Kashibayashi Tetsuo , Kanemoto Hideki , Takahashi Ryuichi , Fujito Ryoko , Chadani Yoshihiro , Tagai Kenji , Shinagawa Shunichiro , Ishii Kazunari , Ikeda Manabu , Kazui Hiroaki 
Published: July 2024

Background: Aggression, a common symptom of Alzheimer’s disease (AD), can impose a significant burden on caregivers, necessitating early institutionalization. Objective: The current study examined the neural basis of aggression and its expression mechanism, to advance the development of effective treatment strategies for aggression in patients with AD. Methods: The study sample included 257 patients; 180 were diagnosed with AD and 77 with amnestic mild cognitive impairment (aMCI). Factor analysis of the neuropsychiatric inventory (NPI) aggression scores was performed, and the correlation between each factor and cerebral blood flow (CBF) was examined via diagnosis of AD or aMCI using statistical parametric mapping. Results: Refusal of care was correlated with reduced CBF in the right hippocampus of patients with AD while no specific related regions could be identified in patients with aMCI. Violent behavior was associated with decreased CBF in the right temporal pole and medial frontal lobe of patients with AD and aMCI. Conclusions: These findings suggest that aggression, measured using NPI includes two distinct symptoms, refusal of care and violent behavior, having different underlying neural bases.
Analysis of measures to increase the energy efficiency of educational buildings of the national university of water and environmental engineering
Authors: Kizyeyev Mykola , Novytska Olha , Kravchenko Nataliia , Protsenko Serhii 
Published: July 2024

The implementation of energy-efficient measures at the National University of Water and Environmental Engineering (NUWEE) was started since 2000. The buildings of NUWEE are located in different parts of Rivne city and Rivne region. Buildings № 1-7 were selected by the Ministry of Education and Science of Ukraine for financing their thermal modernization as part of the loan project "Higher Education of Ukraine. Energy efficiency and sustainable development" with the aim of increasing their energy efficiency. The authors analyzed the measures to increase the energy efficiency of the educational buildings of the NUWEE, namely, the installation of thermal insulation of facades, roofs, floors on the ground and first surfaces, replacement of windows and doors, installation of thermal insulation of pipelines, modernization of automated thermal energy regulation units (ATERU), heating system and lighting, implementation of the energy monitoring and dispatching system, installation of the ventilation system with exhaust air heat recovery. Implementation of the proposed measures will reduce energy consumption and related costs by 60 %, namely by 6,232 MWh/year (compared to the baseline level of energy consumption of 10,286 MWh/year). It will result increasing of the buildings’ comfort and functionality. After the implementation of the described measures, the increase of the energy efficiency class of educational buildings is predicted. The implementation of energy-efficient measures will also lead to the reduction of greenhouse gas emissions by 50 %, namely by 1,648 t/year. Measures that can pay off as soon as possible are the implementation of thermal insulation of pipelines, modernization of ATERU and lighting, implementation of energy monitoring and dispatching systems. The longest payback period will require the installation of ventilation air heat recovery, but this measure is necessary in view of the current reduction in heat energy costs for heating the external supply air in the cold period of the year.
Pengembangan Aplikasi Mobile menggunakan Metode Waterfall untuk Absensi Karyawan
Authors: Yulianti Yulianti , Hidayah Nur , Yulianti Indira Novi , Hilaludin Hilaludin , Saifudin Aries 
Published: July 2024

Absensi kehadiran merupakan kegiatan yang sangat penting dalam proses membaca staf. Perusahaan Indonesia memiliki banyak karyawan. Karyawan adalah variabel yang sangat penting. Setiap perusahaan harus selalu mengelola setiap karyawannya. Mengelola absensi karyawan memiliki dampak yang signifikan bagi sebuah perusahaan, mengingat semakin banyak jumlah perusahaan dan karyawan. Banyak perusahaan, terutama usaha kecil, masih menggunakan presensi manual. Masalah lain yang muncul adalah hilangnya kontrol atas kehadiran karyawan. Sistem absensi manual mudah dioperasikan dan tidak terlalu efektif serta dapat menghambat kemajuan perusahaan. Untuk mempermudah mengelola karyawan ini, kami memerlukan sistem yang memungkinkan setiap karyawan untuk mengonfirmasi kehadiran saat mereka masuk dan keluar. Sistem yang dirancang harus dapat memenuhi kebutuhan pengguna seperti masalah yang dijelaskan. Selain itu, aplikasi harus dapat melakukan check in (masuk) dan check out (keluar) karyawan untuk konfirmasi kehadiran. Sistem absensi ini dibangun dengan waterfall dan diimplementasikan pada perangkat android. Selain itu, akan dibuat sistem untuk mengelola kehadiran dan kedisiplinan karyawan serta meningkatkan efektivitas dan efisiensi sistem absensi. Aplikasi ini memungkinkan karyawan untuk check in (masuk) dan check out (keluar) untuk mengelola kehadiran.
Sistem Informasi Persewaan Alat Pesta Tiga Bintang (Dekorin Aja) Berbasis Codeigniter
Authors: Firmansyah Annas , Hadiono Kristophorus 
Published: July 2024

Persewaan alat pesta tiga bintang merupakan salah satu tempat persewaan alat pesta yang berlokasi di wilayah Ngaliyan Semarang Barat. Persewaan alat pesta tersebut menawarkan berbagai perlengkapan seperti meja, kursi, tenda, dan masih banyak lagi. Tidak hanya peralatan pesta saja, tetapi ada juga paket pernikahan yang ditawarkan. Yang saat ini masih menggunakan secara manual melalui kontak WhatsApp atau datang langsung ke rumah pemilik. Sehingga mempengaruhi berapa lama konsumen menerima jadwal, informasi harga dan layanan yang disediakan oleh pemilik. Untuk menghindari hal tersebut, perlu dibangun sistem pelayanan persewaan alat pesta secara online yang bertujuan untuk membantu menjembatani pemilik kalau ada pesanan yang masuk supaya tidak bertumpukan dengan jadwalnya dan mendapatkan data secara cepat. Sistem yang dibangun menggunakan bootstrap dan framework codeigniter, serta databse MySQL sebagai penyimpanan data untuk laporan persewaannya. Dan menggunakan model Waterfall dalam membuat alur perancangannya dan menggunakan pengujian kotak hitam. Dengan dibangunnya sistem layanan online sewa perlengkapan pesta tiga bintang diharapkan dapat memaksimalkan pelayanan yang cepat dan akurat dalam penyampaian informasi yang diberikan serta mempermudah proses pemesanan bagi konsumen peralatan pesta.
Pendampingan Stase Manajemen pada Pelayanan Obstetri Neonatal Emergency Komprehensif (PONEK)
Authors: Selvia Anisya , Roza Nelli 
Published: July 2024

Bidan merupakan seorang pemberi layanan kesehatan dan harus dapat melaksanakan pelayanan kebidanan dengan melaksanakan manajemen yang baik. Asuhan kebidanan yang profesional dapat dikembangkan dan dilaksanakan oleh bidan khususnya Manajemen pada Pelayanan Obstetri Neonatal Emergency Komprehensif (PONEK). Hal ini dilatarbelakangi oleh semakin meningkatnya kebutuhan masyarakat akan pelayanan kebidanan yang profesional dan adanya tuntutan perkembangan ilmu pengetahuan dan teknologi khususnya pada Pelayanan Obstetri Neonatal Emergency Komprehensif dalam pelayanan kebidanan. Oleh karena itu maka pemberian pelayanan kebidanan harus efektif dan efisien. Tujuan dari kegiatan ini adalah terwujudnya penerapan konsep dan teori manajemen kebidanan khususnya Pelayanan Obstetri Neonatal Emergency Komprehensif (PONEK) dalam peningkatan mutu pelayanan kebidanan di rumah sakit. Metode dalam pendampingan stase manajemen pada pelayanan Obstetri Neonatal Emergency Komprehensif (PONEK) ini menggunakan metode observasi dan studi kasus terkait pelaksanaan PONEK di Rumah Sakit Santa Elisabeth. Metode observasi dilakukan melalui pengamatan terkait pelaksanaan PONEK dalam pelayanan kebidanan. Studi kasus dilakukan melalui pengkajian penatalaksanaan kasus-kasus PONEK yang ada di rumah sakit. Hasil Observasi dan Pengkajian di analisis menggunakan analisis SWOT. Berdasarkan hasil analisis SWOT didapatkan bahwa kondisi Rumah Sakit sangat berpeluang untuk membentuk ruang PONEK sesuai ketentuan dan standar yang berlaku. Berdasarkan hasil analisis tersebut maka dapat disimpulkan bahwa rekomendasi strategi yang dapat diberikan kepada Rumah Sakit adalah dengan cara merubah strategi pelaksanaan layanan PONEK yang disesuaikan dengan standar yang seharusnya.
Efek Kombinasi Terapi Buerger Allen Exercise dan Senam Kaki Diabetes terhadap Ankle Brachial Index Penderita Diabetes
Authors: Heriyanto Hendri , Septiyanti Septiyanti , Delfina Rina 
Published: July 2024

Mengukur sensitivitas kaki dengan Ankle Brachial Index (ABI) dapat digunakan untuk mengidentifikasi gangguan sensitivitas perifer pada penderita diabetes mellitus (DM). Gangguan sensitivitas perifer yang tidak ditangani dengan baik dapat berujung pada berbagai komplikasi, termasuk amputasi kaki. Buerger Allen Exercise (BAE) dan senam kaki diabetes telah dinyatakan memberikan efek yang baik terhadap ABI. Namun demikian penelitian yang menggabungkan kedua latihan ini belumlah diketahui. Penelitian ini bertujuan untuk mengetahui dampak kombinasi terapi BAE dan senam kaki diabetes terhadap peningkatan nilai ABI pada pasien DM. Penelitian ini menggunakan pendekatan kuasi eksperimen dengan desain pre-test dan post-test. Teknik pengambilan sampel menggunakan teknik purposive sampling dengan jumlah sample sebanyak 57 responden, diantaranya 19 orang dalam kelompok intervensi BAE dan senam kaki, 19 orang dalam kelompok BAE (kontrol 1), dan 19 orang dalam kelompok senam kaki (kontrol 2). Hasil analisis menunjukkan perbedaan yang signifikan dalam nilai ABI antara kelompok intervensi dan 2 kelompok kontrol (p value 0,001). Studi ini mencatat bahwa pasien diabetes di wilayah kerja Puskesmas Sawah Lebar Kota Bengkulu memiliki nilai ABI yang lebih tinggi ketika terapi BAE dan senam kaki diabetes digabungkan.
Detection of Non-Formalin Food Additives Acid Compounds in Food Using Purple Sweet Potato (Ipomoea batatas (L.) Lamb) Anthocyanins
Authors: Fauziyah Riska Nurul , Restiyani Fauziah , Yuliastuti, E.S Eko 
Published: July 2024

Purpose – Formalin in food can be detected using anthocyanin pigments in purple sweet potatoes (Ipomoea batatas (L.) Lamb). Anthocyanins turn red or pink on contact with acidic formalin. Concerns arise about similar color changes with other acidic compounds. Thus, this study examines anthocyanin reactions with various acidic compounds—Food Additives Acids: acetic, lactic, citric, phosphoric, ascorbic, benzoic, and tartaric acid.
Methodology –This simple experiment involved 7 test samples and 1 control (formalin). Sample concentrations adhered to BPOM guidelines, and pH levels were measured. Purple sweet potatoes were mixed 1:1 with distilled water. 5 mL of each sample was combined with anthocyanin drops in separate test tubes (10 mL total volume). Observations tracked color change duration (735.40 seconds). pH was measured again post-observation.
Findings – Results showed red coloration in lactic, phosphoric, and acetic acid samples—not always indicating formalin. pH changes after anthocyanin addition can quantitatively detect formalin and acid samples.
Originality – This research has never been conducted before. Previous studies only focused on the detection of formalin acid compounds in food, not about acidic food additives.
Dynamics of HSD17B3 expression in human fetal testis: implications for the role of Sertoli cells in fetal testosterone biosynthesis
Authors: Planinic Ana , Maric Tihana , Himelreich Peric Marta , Jezek Davor , Katusic Bojanac Ana 
Published: July 2024

Introduction: Androgens play a pivotal role in shaping male sexual characteristics, with testosterone being an essential hormone in orchestrating various developmental processes. Testosterone biosynthesis involves a series of enzymatic reactions, among which the 17β-hydroxysteroid dehydrogenase type 3 (HSD17B3) holds significance. While its role in adult Leydig cells is well established, its localization and importance during the fetal period remain less known, especially in humans. This study aims to delineate the dynamics of HSD17B3 expression in human fetal testes to clarify the contribution of specific cell types to testosterone biosynthesis.Methods: Using immunofluorescence staining, we investigated the expression pattern of HSD17B3 in human fetal and adult testicular tissues.Results and discussion: The findings of this study revealed a distinct temporal and cellular expression pattern of HSD17B3 protein in the fetal period. We detected its expression exclusively in Sertoli cells, the highest during the second trimester. This unique localization suggests the inclusion of fetal Sertoli cells in testosterone production during the critical masculinization-programming window. Furthermore, we demonstrated a shift in HSD17B3 expression from Sertoli cells to Leydig cells in adulthood, corroborating findings from rodent studies. This study sheds light on the intricate, still underexplored regulation of steroidogenesis during fetal development, whose disturbance might lead to testicular dysgenesis. Further research is warranted to elucidate the regulatory pathways governing the expression of HSD17B3 and its transition between Sertoli and Leydig cells, potentially paving the way for novel therapeutic interventions in disorders of sexual development.
Nationwide cost and capacity estimates for sedimentary basin geothermal power and implications for geologic CO2 storage
Authors: Cairncross Emily , Ogland-Hand Jonathan D. , Adams Benjamin M. , Middleton Richard S. 
Published: July 2024

Introduction: Sedimentary basins are naturally porous and permeable subsurface formations that underlie approximately half of the United States. In addition to being targets for geologic CO2 storage, these resources could supply geothermal power: sedimentary basin geothermal heat can be extracted with water or CO2 and used to generate electricity. The geothermal power potential of these basins and the accompanying implication for geologic CO2 storage are, however, understudied.Methods: Here, we use the Sequestration of CO2 Tool (SCO2TPRO) and the generalizable GEOthermal techno-economic simulator (genGEO) to address this gap by a) estimating the cost and capacity of sedimentary basin geothermal power plants across the United States and b) comparing those results to nationwide CO2 sequestration cost and storage potential estimates.Results and discussion: We find that across the United States, using CO2 as a geothermal heat extraction fluid reduces the cost of sedimentary basin power compared to using water, and some of the lowest cost capacity occurs in locations not typically considered for their geothermal resources (e.g., Louisiana, South Dakota). Additionally, using CO2 effectively doubles the sedimentary basin geothermal resource base, equating to hundreds of gigawatts of new capacity, by enabling electricity generation in geologies that are otherwise (with water) too impermeable, too thin, too cold, or not deep enough. We find there is competition for the best sedimentary basin resources between water- and CO2-based power, but no overlap between the lowest-cost resources for CO2 storage and CO2-based power. In this way, our results suggest that deploying CO2-based power may increase the cost of water based systems (by using the best resources) and the cost of CO2 storage (by storing CO2 in locations that otherwise may not be targeted). As such, our findings demonstrate that determining the best role for sedimentary basins within the energy transition may require balancing tradeoffs between competing priorities.
Trend analysis of long-time series habitat quality in Beijing based on multiple models
Authors: Wei Jiaming , Jin Yi , Tan Qilin , Liu Fei , Ding Chi , Li Tiantian , Luo Ji , Hu Chen , Cui Xiaohong , Liu Yuheng , Zheng Xiaoyi , Zhang Guiwei 
Published: July 2024

This study selects Beijing from 1980 to 2020 as the research area, utilizing high temporal resolution land use data to analyze through the habitat quality module of the InVEST model. Unlike previous research, this study employs the Theil-Sen Median method and Mann-Kendall test to analyze the trend changes in habitat quality more accurately. This method has significant advantages in dealing with non-linear and non-normally distributed data over long time series, providing a more accurate and reliable analysis of habitat quality trends. Methodologically, the study first collects and organizes the land use type data of Beijing from 1980 to 2020, then uses the habitat quality module of the InVEST model to process and analyze the data of each year, assessing the impact of different land use types on habitat quality. Subsequently, the Theil-Sen Median method and Mann-Kendall test are used to analyze the time series trend of habitat quality, to identify and quantify the trend and significance of habitat quality changes. The results show that over the past 40 years, the area of construction land in Beijing has significantly expanded, leading to a compression of other types of land. The spatial distribution of habitat quality shows a clear difference between the two sides divided by a line connecting the northeast and southwest, with the west side being the area of good habitat quality and the east side being poorer. In the past 10 years, the overall habitat quality has improved, but most areas still show a decreasing trend, especially in the western and northern mountainous areas where habitat quality has significantly declined. Based on these findings, it is recommended that future urban planning and land management should pay more attention to the protection and improvement of habitat quality, especially the restoration work for areas with poor habitat quality.
The plasma lipids with different fatty acid chains are associated with the risk of hemorrhagic stroke: a Mendelian randomization study
Authors: Zhang Xingkai , Zhu Xiaoyu , Shi Qinghai 
Published: July 2024

Background and objectiveHemorrhagic stroke, characterized by acute bleeding due to cerebrovascular lesions, is associated with plasma lipids and endothelial damage. The causal relationship between genetic plasma lipid levels and hemorrhagic stroke remains unclear. This study employs a two-sample Mendelian randomization (MR) analysis to explore the causal relationship between plasma lipid profiles with different fatty acid chains and the risk of intracerebral and subarachnoid hemorrhage, the two main subtypes of hemorrhagic stroke.MethodsThe datasets for exposure and outcome summary statistics were obtained from publicly available sources such as the GWAS Catalog, IEU OpenGWAS project, and FinnGen. The two-sample MR analysis was employed to initially assess the causal relationship between 179 plasma lipid species and the risk of intracerebral and subarachnoid hemorrhage in the Finnish population, leading to the identification of candidate lipids. The same methods were applied to reanalyze data from European populations and conduct a meta-analysis of the candidate lipids. The Inverse Variance Weighting (IVW) method served as the primary analysis for causal inference, with additional methods used for complementary analyses. Sensitivity analysis was conducted to clarify causal relationships and reduce biases.ResultsTwo analyses using Mendelian randomization were performed, followed by meta-analyses of the results. A causal relationship was established between 11 specific lipid species and the occurrence of intracerebral hemorrhage within the European population. Additionally, 5 distinct lipid species were associated with subarachnoid hemorrhage. Predominantly, lipids with linoleic acid and arachidonic acid side chains were identified. Notably, lipids containing arachidonic acid chains (C20:4) such as PC 18:1;0_20:4;0 consistently showed a decreased risk of both intracerebral hemorrhage [p &lt; 0.001; OR(95% CI) = 0.892(0.835–0.954)] and subarachnoid hemorrhage [p = 0.002; OR(95% CI) = 0.794(0.689–0.916)]. Conversely, lipids with linoleic acid chains (C18:2) were associated with an increased risk of intracerebral hemorrhage.ConclusionThis study identifies a potential causal relationship between lipids with different fatty acid side chains and the risk of intracerebral and subarachnoid hemorrhagic stroke, improving the understanding of the mechanisms behind the onset and progression of hemorrhagic stroke.
The effects of physical activity on adolescents’ depression: evidence from China
Authors: Chen Hongmei , Liu Meng , Zhao Wenqing , Wei Hanlin , Zhang Ying , Li Shunguo 
Published: July 2024

BackgroundDepression is becoming a common threat to the mental health of Chinese adolescents. As an intermediate stage between being healthy and having depression, identifying factors influencing depressive may contribute to providing more options for the prevention and treatment of depression.ObjectiveThe study aims to explore the effects of physical activity on adolescent depression, focusing on the times and hours of activity per week.MethodsThe study used a cross-sectional dataset collected in Ruyang County, Henan Province in September 2022, including a sample of 5,629 adolescents in 31 compulsory public schools in the county. We utilized Ordinary Least Squares (OLS) to analyze the impact of physical activity on adolescents’ depression scores, and probit model to analyze the influence of physical activity on adolescents’ depression. To examine whether there is a U-shaped relationship between physical activity and depression, we included the squared terms of times and hours of activity in models.ResultsThe results showed that: (1) The times of physical activity significantly reduces Chinese adolescent depression. An increase in physical activity by one time per week is associated with a mean decrease of 0.354 points in depression scores (p &lt; 0.01). However, an increase of one time of physical activity per week is associated with an average 1% increase in the likelihood of experiencing depression(p &lt; 0.05), while the hours of physical activity was statistically insignificant. (2) Physical activity has a U-shaped (not linear) relationship with adolescent depression, with 7–8 times per week or 7–9 h of physical activity per week being the optimal range.ConclusionThe study found that increasing the frequency of physical activity positively impacts adolescent depression, while increasing the hours does not show a significant association. Furthermore, a U-shaped relationship exists between times of activity, hours of activity, and adolescent depression, suggesting that moderate activity is optimal.