bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Significance of the European LeukemiaNet Standardized System for Reporting Cytogenetic and Molecular Alterations in Adults With Acute Myeloid Leukemia
Authors: Mrózek Krzysztof , Marcucci Guido , Nicolet Deedra , Maharry Kati S. , Becker Heiko , Whitman Susan P. , Metzeler Klaus H. , Schwind Sebastian , Wu Yue-Zhong , Kohlschmidt Jessica , Pettenati Mark J. , Heerema Nyla A. , Block AnneMarie W. , Patil Shivanand R. , Baer Maria R. , Kolitz Jonathan E. , Moore Joseph O. , Carroll Andrew J. , Stone Richard M. , Larson Richard A. , Bloomfield Clara D. 
Published: September 2012

Purpose To evaluate the prognostic significance of the international European LeukemiaNet (ELN) guidelines for reporting genetic alterations in acute myeloid leukemia (AML). Patients and Methods We analyzed 1,550 adults with primary AML, treated on Cancer and Leukemia Group B first-line trials, who had pretreatment cytogenetics and, for cytogenetically normal patients, mutational status of NPM1, CEBPA, and FLT3 available. We compared complete remission (CR) rates, disease-free survival (DFS), and overall survival (OS) among patients classified into the four ELN genetic groups (favorable, intermediate-I, intermediate-II, adverse) separately for 818 younger (age < 60 years) and 732 older (age ≥ 60 years) patients. Results The percentages of younger versus older patients in the favorable (41% v 20%; P < .001), intermediate-II (19% v 30%; P < .001), and adverse (22% v 31%; P < .001) genetic groups differed. The favorable group had the best and the adverse group the worst CR rates, DFS, and OS in both age groups. Both intermediate groups had significantly worse outcomes than the favorable but better than the adverse group. Intermediate-I and intermediate-II groups in older patients had similar outcomes, whereas the intermediate-II group in younger patients had better OS but not better CR rates or DFS than the intermediate-I group. The prognostic significance of ELN classification was confirmed by multivariable analyses. For each ELN group, older patients had worse outcomes than younger patients. Conclusion The ELN classification clearly separates the genetic groups by outcome, supporting its use for risk stratification in clinical trials. Because they have different proportions of genetic alterations and outcomes, younger and older patients should be reported separately when using the ELN classification.
Compressive syndrome of internal jugular veins in multiple sclerosis: does it matter?
Authors: Radak Dj , Tanaskovic S , Antonic Z , Kolar J , Aleksic N , Ilijevski N 
Published: September 2012

Objectives Condition known as chronic cerebrospinal venous insufficiency (CCSVI) is characterized by insufficient cerebral vein drainage in patients with multiple sclerosis (MS) and internal jugular vein (IJV), vertebral and/or azygos veins stenoses. However, external compression on the IJV was not clearly described as a potential cause of CCSVI. We aim to present a case of CCSVI in a patient with MS caused by bilateral IJV inverted valves combined with IJV external compression by carotid bulb. Methods A 31-year-old female patient was admitted to our institute for IJV and vertebral veins morphological and haemodynamical assessment after being treated for MS for the last 14 years. Colour Doppler ultrasonography showed right IJV prestenotic dilation and inverted valves in both IJV. Computerized tomography angiography showed bilateral IJV compression by carotid bulb. Haemodynamical Doppler parameters showed that external IJV compression significantly contributed to CCSVI occurrence. Results Bilateral IJV confluence percutaneous angioplasty (PTA) was done, and the patient was discharged for further neurological examination. Partial carbon dioxide pressure was significantly lower in the distal part of both IJV following PTA and oxygen saturation increased. Conclusion In the case presented, PTA of the IJV confluence resulted in haemodynamic improvement despite the presence of IJV external compression.
A tutorial on optics for ultrafast laser materials processing: basic microprocessing system to beam shaping and advanced focusing methods
Authors: Sugioka Koji , Cheng Ya 
Published: September 2012

Abstract
Ultrafast lasers have excellent characteristics for materials processing in terms of precision and quality. This tutorial paper introduces the basic concepts of ultrafast laser materials processing and the structure and key components of typical ultrafast laser microprocessing systems. The emphasis is on the pulse-shaping devices and systems for controlling and manipulating the spatial, temporal, and polarization properties of focused femtosecond laser pulses.
Sodium Intake and Blood Pressure Among US Children and Adolescents
Authors: Yang Quanhe , Zhang Zefeng , Kuklina Elena V. , Fang Jing , Ayala Carma , Hong Yuling , Loustalot Fleetwood , Dai Shifan , Gunn Janelle P. , Tian Niu , Cogswell Mary E. , Merritt Robert 
Published: September 2012

OBJECTIVE:To assess the association between usual dietary sodium intake and blood pressure among US children and adolescents, overall and by weight status.METHODS:Children and adolescents aged 8 to 18 years (n = 6235) who participated in NHANES 2003–2008 comprised the sample. Subjects’ usual sodium intake was estimated by using multiple 24-hour dietary recalls. Linear or logistic regression was used to examine association between sodium intake and blood pressure or risk for pre-high blood pressure and high blood pressure (pre-HBP/HPB).RESULTS:Study subjects consumed an average of 3387 mg/day of sodium, and 37% were overweight/obese. Each 1000 mg per day sodium intake was associated with an increased SD score of 0.097 (95% confidence interval [CI] 0.006–0.188, ∼1.0 mm Hg) in systolic blood pressure (SBP) among all subjects and 0.141 (95% CI: –0.010 to 0.298, ∼1.5 mm Hg) increase among overweight/obese subjects. Mean adjusted SBP increased progressively with sodium intake quartile, from 106.2 mm Hg (95% CI: 105.1–107.3) to 108.8 mm Hg (95% CI: 107.5–110.1) overall (P = .010) and from 109.0 mm Hg (95% CI: 107.2–110.8) to 112.8 mm Hg (95% CI: 110.7–114.9; P = .037) among those overweight/obese. Adjusted odds ratios comparing risk for pre-HBP/HPB among subjects in the highest versus lowest sodium intake quartile were 2.0 (95% CI: 0.95–4.1, P = .062) overall and 3.5 (95% CI: 1.3–9.2, P = .013) among those overweight/obese. Sodium intake and weight status appeared to have synergistic effects on risk for pre-HBP/HPB (relative excess risk for interaction = 0.29 (95% CI: 0.01–0.90, P &lt; .05).CONCLUSIONS:Sodium intake is positively associated with SBP and risk for pre-HBP/HPB among US children and adolescents, and this association may be stronger among those who are overweight/obese.
Hypertension Screening During Ambulatory Pediatric Visits in the United States, 2000–2009
Authors: Shapiro Daniel J. , Hersh Adam L. , Cabana Michael D. , Sutherland Scott M. , Patel Anisha I. 
Published: September 2012

BACKGROUND AND OBJECTIVE:Hypertension occurs in 2% to 5% of children in the United States, and its prevalence has increased during the obesity epidemic. There is no consensus among professional organizations about how frequently blood pressure should be measured in children &gt;3 years old. The purpose of this study was to estimate the frequency of hypertension screening during ambulatory pediatric visits in the United States and to determine patient- and provider-level factors associated with screening during visits specifically for preventive care.METHODS:We analyzed data from a nationally representative sample of ambulatory visits by using the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey from 2000 through 2009. In the subset of visits involving patients aged 3 to 18 years, we estimated the frequency of screening during all visits, preventive visits, and preventive visits in which overweight/obesity was diagnosed. We used multivariable logistic regression to identify patient- and provider-level factors associated with screening.RESULTS:Hypertension screening occurred during 35% of ambulatory pediatric visits, 67% of preventive visits, and 84% of preventive visits in which overweight/obesity was diagnosed. Between 2000 and 2009, the frequency of screening increased in all visits and in preventive visits. Factors independently associated with screening included older age and overweight/obesity diagnosis.CONCLUSIONS:Providers do not measure blood pressure in two-thirds of pediatric visits and one-third of pediatric preventive visits. Providers may understand the importance of screening among overweight/obese children; however, efforts to encourage routine screening, particularly in young children, may be needed.
Estimating the Population Size of Men Who Have Sex with Men in the United States to Obtain HIV and Syphilis Rates§
Authors: Purcell David W , Johnson Christopher H , Lansky Amy , Prejean Joseph , Stein Renee , Denning Paul , Gau1 Zaneta , Weinstock Hillard , Su John , Crepaz Nicole 
Published: September 2012

Background:
CDC has not previously calculated disease rates for men who have sex with men (MSM) because there is no single comprehensive source of data on population size. To inform prevention planning, CDC developed a national population size estimate for MSM to calculate disease metrics for HIV and syphilis.

Methods:
We conducted a systematic literature search and identified seven surveys that provided data on same-sex behavior in nationally representative samples. Data were pooled by three recall periods and combined using meta-analytic procedures. We applied the proportion of men reporting same-sex behavior in the past 5 years to U.S. census data to produce a population size estimate. We then calculated three disease metrics using CDC HIV and STD surveillance data and rate ratios comparing MSM to other men and to women.

Results:
Estimates of the proportion of men who engaged in same-sex behavior differed by recall period: past year = 2.9% (95%CI, 2.6–3.2); past five years = 3.9% (3.5–4.4); ever = 6.9% (5.1–8.6). Rates on all 3 disease metrics were much higher among MSM than among either other men or women (38 to 109 times as high).

Conclusions:
Estimating the population size for MSM allowed us to calculate rates for disease metrics and to develop rate ratios showing dramatically higher rates among MSM than among other men or women. These data greatly improve our understanding of the disproportionate impact of these diseases among MSM in the U.S. and help with prevention planning.
Piloting a System for Behavioral Surveillance Among Heterosexuals at Increased Risk of HIV in the United States
Authors: DiNenno Elizabeth A , Oster Alexandra M , Sionean Catlainn , Denning Paul , Lansky Amy 
Published: September 2012

Objectives:During the past decade, the number and proportion of reported HIV cases in the United States acquired through heterosexual contact has increased markedly. CDC employs the National HIV Behavioral Surveillance System (NHBS) to monitor risk behaviors and HIV prevalence in high-risk populations. To identify a target population for conducting NHBS among heterosexuals at increased risk for HIV (NHBS-HET), CDC designed, implemented and evaluated a pilot study.Methods:The pilot study was conducted in 25 US metropolitan statistical areas in 2006-7. We recruited men and women who reported sex with at least one opposite-sex partner during the past year for a behavioral survey and HIV test. We investigated the relationship between newly diagnosed HIV infection and individual risk behaviors, sexual network characteristics, and social-structural characteristics to arrive at a definition of a heterosexual at increased risk of HIV.Results:Of 14,750 participants in the analysis, 207 (1.4%) had newly diagnosed HIV infection. Using low socioeconomic status (SES) as a criterion for defining a heterosexual at increased risk for HIV resulted in optimal rates of HIV prevalence, specificity, sensitivity and practicality.Conclusions:Results from the NHBS pilot study underscore the key role of social factors as determinants of HIV infection risk among U.S. heterosexuals, and low SES was incorporated into the definition of a heterosexual at increased risk for HIV in NHBS-HET cycles. Future cycles of NHBS-HET will help tailor prevention programs for those populations most at risk of HIV in the US.
A Multiple-Model Approach for Synchronous Generator Nonlinear System Identification
Authors: Ahmadi Seyed , Karrari Mehdi 
Published: September 2012

A Multiple-Model Approach for Synchronous Generator Nonlinear System Identification
In this paper, a multiple model approach is proposed for the identification of synchronous generators. In the literature, the same structure often is used for all local models. Therefore, to obtain a precise model for the operating condition of the synchronous generator with severely nonlinear behavior, many local models are required. The proposed method determines the complexity of local models based on complexity of behavior of the synchronous generator at different operating conditions. There are two choices for increasing model precision at each iteration of the proposed method: (i) increasing the number of local models in one region, or (ii) increasing local model complexity in the same region. The proposed method has been tested on experimental data collected on a 3 kVA micro-machine. In the study, the field voltage is considered as the input and the active output power and the terminal voltage are considered as the outputs of the synchronous generator. The proposed method provides a more precise model with fewer parameters compared to some well known methods such as LOLIMOT and global polynomial models.
Bipolar radiofrequency-induced thermotherapy of great saphenous vein: Our initial experience
Authors: Kasi Venkatesh , Kalyanpur Tejas M , Narsinghpura Kaustubh , Chakravarthy Deyananda , Mehta Pankaj , Cherian Mathew 
Published: September 2012

AbstractThe incidence of varicose veins in lower limbs is increasing in the Indian subcontinent. With the advent of radiofrequency ablation (RFA), an effective minimally invasive technique is now available to treat varicose veins. RFA can be performed with either unipolar or bipolar probes. We present a simple technique for bipolar radiofrequency-induced thermotherapy of the great saphenous vein. This can be a safe and effective alternative to surgical procedures.
Technical Note: Thoracic duct embolization for treatment of chylothorax: A novel guidance technique for puncture using combined MRI and fluoroscopy
Authors: Praveen Alampath , Sreekumar Karumathil Pullara , Nazar Puthukudiyil Kader , Moorthy Srikanth 
Published: September 2012

AbstractThoracic duct embolization (TDE) is an established radiological interventional procedure for thoracic duct injuries. Traditionally, it is done under fluoroscopic guidance after opacifying the thoracic duct with bipedal lymphangiography. We describe our experience in usinga heavily T2W sequence for guiding thoracic duct puncture and direct injection of glue through the puncture needle without cannulating the duct.
Endothelial Nitric Oxide Synthase Glu298Asp Polymorphism as a Risk Factor for Prostate Cancer
Authors: Ziaei Seyed Amir Mohsen , Samzadeh Mohammad , Jamaldini Seyed Hamid , Afshari Mahdi , Haghdoost Ali Akbar , Hasanzad Mandana 
Published: September 2012

Background The endothelial form of nitric oxide synthases (eNOS) seems to have an important role in vascular development, maintenance of the vascular tone and tumor growth in human prostate cancer (PC). The purpose of this study was to investigate the association between grade and stage of disease, age of diagnosis, vascular or perineural invasion, pre-diagnostic plasma prostate-specific antigen (PSA) levels, prostate cancer risk and Glu298Asp polymorphism of the eNOS gene. Methods Ninety-five prostate cancer patients and 111 benign prostate hyperplasia subjects were included. The Glu298Asp polymorphism of the eNOS gene was determined by polymerase chain reaction and restriction fragment length polymorphism Results The odds ratio (OR) between the GT and GG polymorphism was 0.76, indicating that the presence of the GT polymorphism decreased the risk of prostate cancer of more than 20% compared to the GG polymorphism. This difference, however, was not statistically significant. The GT polymorphism had an inverse association with cancer grade compared to the reference group (OR=0.47, p value=0.2). Conclusions These results suggest that prostate cancer development is not associated with the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in our population. Further studies in larger samples are needed to confirm our results and characterize the molecular mechanisms by which eNOS is involved in the susceptibility to prostate cancer.
The Roles of Southeast Asian School Managers as Instructional Leaders: An Assessment
Authors: Baliton Fructuoso C. 
Published: September 2012

Schools must consciously seek principals who are instructional leaders. Principals who are comfortable with providing instructional support to teachers are likely to have been good teachers themselves (Glanz 2006). This descriptive method of research assessed the roles of Southeast Asian school managers as instructional leaders in the four domains of teaching responsibilities and explored relationships among the variables of the study namely: planning and preparation, the classroom environment, instruction, and professional responsibilities. The T-test determined the differences between the male and the female and between the Filipinos and the Non-Filipinos respondents which resulted to non-significant differences between neither of the two groups. The F-test was used to determine the significant relationships among the four domains of teaching responsibilities which established significant relationships between three pairs of domains. This research concluded that the SEA school managers are very comfortable with their level in working with teachers on content and pedagogical knowledge, knowledge of students and resources, ability to select instructional goals, and the degree to which they help teachers assess learning as well as the degree to which they encourage and create an environment of respect and caring and establish a culture for learning related to many aspects of classroom environment. Keywords - Southeast Asian School Managers, Instructional leadership, domains of teaching responsibilities, planning and preparation, classroom environment, instruction, professional responsibilities.
Double Stimuli‐Responsive Isoporous Membranes via Post‐Modification of pH‐Sensitive Self‐Assembled Diblock Copolymer Membranes
Authors: Clodt Juliana Isabel , Filiz Volkan , Rangou Sofia , Buhr Kristian , Abetz Clarissa , Höche Daniel , Hahn Janina , Jung Adina , Abetz Volker 
Published: September 2012

AbstractDouble stimuli‐responsive membranes are prepared by modification of pH‐sensitive integral asymmetric polystyrene‐b‐poly(4‐vinylpyridine) (PS‐b‐P4VP) diblock copolymer membranes with temperature‐responsive poly(N‐isopropylacrylamide) (pNIPAM) by a surface linking reaction. PS‐b‐P4VP membranes are first functionalized with a mild mussel‐inspired polydopamine coating and then reacted via Michael addition with an amine‐terminated pNIPAM‐NH2 under slightly basic conditions. The membranes are thoroughly characterized by nuclear magnetic resonance (1H‐NMR), Fourier transform infrared spectroscopy and X‐ray‐induced photoelectron spectroscopy. Additionally dynamic contact angle measurements are performed comparing the sinking rate of water droplets at different temperatures. The pH‐ and thermo‐double sensitivities of the modified membranes are proven by determining the water flux under different temperature and pH conditions.
Biomimetic Calcium Carbonate Concentric Microgrooves with Tunable Widths for Promoting MC3T3‐E1 Cell Functions
Authors: Wu Xiaohui , Wang Shanfeng 
Published: September 2012

AbstractBiomimetic, self‐assembled calcium carbonate (CaCO3) concentric microgrooves with groove widths of 5.0 and 10 μm were fabricated through simply controlling incubation temperature. Mouse pre‐osteoblastic MC3T3‐E1 cells were cultured on flat and microgrooved substrates of CaCO3 and their adhesion, spreading, proliferation, alkaline phosphatase activity, and calcium content were remarkably enhanced by the microgrooves, in particular, the narrower ones. Furthermore, focal adhesions and actin filaments of MC3T3‐E1 cells could be aligned on both 5.0‐μm and 10‐μm‐wide CaCO3 grooves. Compared with the original round nuclei on the flat substrates and expanded round nuclei on the narrower microgrooves, the MC3T3‐E1 cell nuclei on 10‐μm‐wide CaCO3 grooves demonstrated preferred entrapment in the grooves and significant alignment with a smaller area after two‐day culture.
An inherited LMNA gene mutation in atypical Progeria syndrome
Authors: Doubaj Yassamine , De Sandre‐Giovannoli Annachiara , Vera Esteves‐Vieira , Navarro Claire Laure , Elalaoui Siham Chafai , Tajir Mariam , Lévy Nicolas , Sefiani Abdelaziz 
Published: September 2012

AbstractHutchinson–Gilford Progeria syndrome (HGPS) is a rare genetic disorder, characterized by several clinical features that begin in early childhood, recalling an accelerated aging process. The diagnosis of HGPS is based on the recognition of common clinical features and detection of the recurrent heterozygous c.1824C>T (p.Gly608Gly) mutation within exon 11 in the Lamin A/C encoding gene (LMNA). Besides “typical HGPS,” several “atypical progeria” syndromes (APS) have been described, in a clinical spectrum ranging from mandibuloacral dysplasia to atypical Werner syndrome. These patients's clinical features include progeroid manifestations, such as short stature, prominent nose, premature graying of hair, partial alopecia, skin atrophy, lipodystrophy, skeletal anomalies, such as mandibular hypoplasia and acroosteolyses, and in some cases severe atherosclerosis with metabolic complications. APS are due in several cases to de novo heterozygous LMNA mutations other than the p.Gly608Gly, or due to homozygous BAFN1 mutations in Nestor–Guillermo Progeria syndrome (NGPS). We report here and discuss the observation of a non‐consanguineous Moroccan patient presenting with atypical progeria. The molecular studies showed the heterozygous mutation c.412G>A (p.Glu138Lys) of the LMNA gene. This mutation, previously reported as a de novo mutation, was inherited from the apparently healthy father who showed a somatic cell mosaicism. © 2012 Wiley Periodicals, Inc.