bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult Age‐Related Differences in the Misinformation Effect for Context‐Consistent and Context‐Inconsistent Objects
Authors: Prull Matthew W. , Yockelson Melissa B. 
Published: March 2013

SummaryThe present study examined age‐related differences in the misinformation effect for objects that were consistent or inconsistent with their environmental settings. Young and older adults viewed one of two slide sequences, each containing context‐consistent items (e.g., a blender in a kitchen setting or a saw in a woodshop setting) and context‐inconsistent items (a saw in a kitchen setting or a blender in a woodshop setting). After receiving misinformation through post‐event narratives, participants received tests of yes/no recognition requiring remember/know judgments (Experiments 1–3) and source monitoring (Experiments 2 and 3) for slide details. Although age‐related differences in the misinformation effect were nonreliable, older adults tended to report misinformation as remembered more often than young adults, and source monitoring tests reduced the misinformation effect for both age groups. Misinformation effects were equivalent or larger for inconsistent objects than for consistent objects. Theoretical and practical implications of these results are discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Graphene Oxide‐Based Antibacterial Cotton Fabrics
Authors: Zhao Jinming , Deng Bo , Lv Min , Li Jingye , Zhang Yujie , Jiang Haiqing , Peng Cheng , Li Jiang , Shi Jiye , Huang Qing , Fan Chunhai 
Published: March 2013

AbstractGraphene oxide (GO) is an excellent bacteria‐killing nanomaterial. In this work, macroscopic applications of this promising nanomaterial by fixing GO sheets onto cotton fabrics, which possess strong antibacterial property and great laundering durability, are reported. The GO‐based antibacterial cotton fabrics are prepared in three ways: direct adsorption, radiation‐induced crosslinking, and chemical crosslinking. Antibacterial tests show that all these GO‐containing fabrics possess strong antibacterial property and could inactivate 98% of bacteria. Most significantly, these fabrics can still kill >90% bacteria even after being washed for 100 times. Also importantly, animal tests show that GO‐modified cotton fabrics cause no irritation to rabbit skin. Hence, it is believed that these flexible, foldable, and re‐usable GO‐based antibacterial cotton fabrics have high promise as a type of new nano‐engineered antibacterial materials for a wide range of applications.
Separation and purification of carbon nanotubes using froth flotation with three sequential pretreatment steps of catalyst oxidation, catalyst removal, and silica dissolution
Authors: Lertrojanachusit Nattapong , Pornsunthorntawee Orathai , Kitiyanan Boonyarach , Chavadej Jittipan , Chavadej Sumaeth 
Published: March 2013

ABSTRACTCarbon nanotubes (CNTs) with a carbon content of 3% were synthesized via the disproportionation of CO over a CoMo/SiO2 catalyst. The proposed purification technique consisted of four sequential steps: oxidative treatment, acid leaching, silica dissolution, and froth flotation. The as‐synthesized CNTs were oxidized at 250 °C before being treated with a 5‐m HCl solution at 80 °C and a sonication time of 6 h, resulting in a catalyst removal of 90% and an increase in carbon content to 4%. For the silica dissolution, the CNTs were treated with a 0.5‐m NaOH solution at 70 °C and a sonication time of 12 h, leading to a silica removal of 70% and an increase in carbon content to 35%. The froth flotation technique was employed to separate the CNTs from the remaining silica using two types of surfactants: linear ethoxylated alcohol with an average degree of polymerization of 7 and a linear alkyl chain of 12–14 carbon number (Surfonic L24‐7) and sodium dodecyl benzene sulfonate (SDBS). The separation performance was maximized at a Surfonic L24‐7‐to‐SDBS molar ratio of 1 : 12 with a total surfactant concentration of 230 mg/L, yielding a carbon content of 76%. © 2013 Curtin University of Technology and John Wiley & Sons, Ltd.
Dynamic Games for Stochastic Systems with Delay
Authors: Mukaidani Hiroaki 
Published: March 2013

AbstractThis paper discusses dynamic games for a class of linear stochastic delay systems governed by Itô's stochastic differential equation. The Pareto and Nash strategies are developed by solving cross‐coupled matrix inequalities. To obtain these strategy sets, new cross‐coupled algebraic equations (CSAEs) are established on the basis of the Karush‐Kuhn‐Tucker (KKT) conditions, which constitute the necessary conditions. It is noteworthy that the state feedback strategies can be obtained by solving the linear matrix inequality (LMI) recursively. Finally, a numerical example showing the effectiveness of the proposed methods and the attained cost bounds is described.
Relaxed Stability Conditions for Switched Systems with Dwell Time
Authors: Tanner Herbert G. 
Published: March 2013

AbstractThe paper presents asymptotic, and input‐to‐state stability results, for switched systems with dwell time in which the switching signal is not arbitrary, but is rather chosen as part of the control design strategy. Then, appropriate switching policies allow the use of functions without sign‐definite time derivatives in lieu of a common Lyapunov‐like function.
Aggregation of polyQ‐extended proteins is promoted by interaction with their natural coiled‐coil partners
Authors: Petrakis Spyros , Schaefer Martin H. , Wanker Erich E. , Andrade‐Navarro Miguel A. 
Published: March 2013

AbstractPolyglutamine (polyQ) diseases are genetically inherited neurodegenerative disorders. They are caused by mutations that result in polyQ expansions of particular proteins. Mutant proteins form intranuclear aggregates, induce cytotoxicity and cause neuronal cell death. Protein interaction data suggest that polyQ regions modulate interactions between coiled‐coil (CC) domains. In the case of the polyQ disease spinocerebellar ataxia type‐1 (SCA1), interacting proteins with CC domains further enhance aggregation and toxicity of mutant ataxin‐1 (ATXN1). Here, we suggest that CC partners interacting with the polyQ region of a mutant protein, increase its aggregation while partners that interact with a different region reduce the formation of aggregates. Computational analysis of genetic screens revealed that CC‐rich proteins are highly enriched among genes that enhance pathogenicity of polyQ proteins, supporting our hypothesis. We therefore suggest that blocking interactions between mutant polyQ proteins and their CC partners might constitute a promising preventive strategy against neurodegeneration.
Thermodynamic assessment of domain‐domain interactions and in vitro activities of mesophilic and thermophilic ribosome recycling factors
Authors: Uchiyama Susumu , Ohshima Atsushi , Yoshida Takuya , Ohkubo Tadayasu , Kobayashi Yuji 
Published: March 2013

ABSTRACTRibosome recycling factor (RRF) is essential for bacterial growth. Structural studies revealed that RRF consists of two domains connected by two short polypeptides at the hinge region. Here, we evaluated the intrinsic stabilities (ΔG*s) of the two domains and the free energy of the domain‐domain interactions (ΔGint) for mesophilic RRF (RRF from Escherichia coli, EcRRF) and thermophilic RRF (RRF from Thermus thermophilus, TtRRF) by using differential scanning calorimetry and circular dichroic spectroscopy. Despite single endothermic peaks, a higher than unity value for the ratio of calorimetric enthalpy to van't Hoff enthalpy of the unfolding indicated the presence of unfolding intermediates for both RRFs. Deconvolution analysis based on statistical thermodynamics employing multiple states of the unfolding process with domain‐domain interactions allowed us to determine ΔG*s of each domain and ΔGint. The results indicated that domain I has a higher unfolding temperature than domain II and that it stabilizes domain II through ΔGint, giving rise to an apparent single peak of unfolding. Interestingly, the estimated ΔGint values of 6.28 kJ/mol for EcRRF and 26.28 kJ/mol for TtRRF reflect the observation that only EcRRF has recycling activity at ambient temperature. Our present study suggests the importance of a moderate ΔGint for biological activity of multidomain proteins. © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 366–379, 2013.
Potential of collagen‐like triple helical peptides as drug carriers: Their in vivo distribution, metabolism, and excretion profiles in rodents
Authors: Yasui Hiroyuki , Yamazaki Chisato M. , Nose Hiroshi , Awada Chihiro , Takao Toshifumi , Koide Takaki 
Published: March 2013

ABSTRACTCollagen‐model peptides composed of (X‐Y‐Gly)n sequences were used to study the triple helical structure of collagen. We report the stability of these collagen‐like peptides in biological fluids, and their pharmacokinetics including distribution, metabolism, and excretion in animals. A typical collagen‐model peptide, H‐(Pro‐Hyp‐Gly)10‐OH, was found to be extremely stable in the plasma and distributed mainly in the vascular blood space, and was eliminated through glomerular filtration in the kidneys. Triple helical peptides of (X‐Y‐Gly)n sequences were quantitatively recovered from the urine of rats after intravenous injection regardless of the differences in peptide net charge between −3 and +6 per triple helix. In contrast, the renal clearance became less efficient when the number of triplet repeats (n) was 12 or more. We also demonstrated the application of a collagen‐like triple helical peptide as a novel drug carrier in the blood with a high urinary excretion profile. We further demonstrated that a collagen‐like triple helical peptide conjugated to a spin probe, PROXYL, has the potential to evaluate the redox status of oxidative stress‐induced animals in vivo. © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 705–713, 2013.
Opportunities for improvement in the management of patients who die from haemorrhage after trauma
Authors: O'Reilly D , Mahendran K , West A , Shirley P , Walsh M , Tai N 
Published: March 2013

Abstract

Background
Bleeding is the leading cause of preventable death after injury. This retrospective study aimed to characterize opportunities for performance improvement (OPIs) identified in patients who died from bleeding and were considered by the quality improvement system of a major trauma centre.

Methods
All trauma deaths in 2006–2010 were discussed at the trauma morbidity and mortality meeting. Deaths from haemorrhage were identified and subjected to qualitative and quantitative evaluation. OPIs were identified and remedial action was taken.

Results
During the study interval there were 7511 trauma team activations; 423 patients died. Haemorrhage was the second most common cause of death, in 112 patients, and made a substantial contribution to death in a further 15. For 84 of these 127 patients, a total of 150 OPIs were identified. Most arose in the emergency department, but involved personnel from many departments. Problems with decision-making were more common than errors in technical skill. OPIs frequently involved the decision between surgery, radiology and further investigation. Delayed and inappropriate surgery occurred even when investigation and diagnosis were appropriate. The mortality rate among patients presenting in shock fell significantly over the study interval (P &lt; 0·026).

Conclusion
Problems with judgement are more common than those of skill. Death from traumatic haemorrhage is associated with identifiable, remediable failures in care. The implementation of a systematic trauma quality improvement system was associated with a fall in the mortality rate among patients presenting in shock.
Development and validation of a sensitive and high‐throughput LC‐MS/MS method for the simultaneous determination of esomeprazole and naproxen in human plasma
Authors: Gopinath Shanmugam , Kumar Ramadass Satiesh , Shankar Madhira bhawani , Danabal Palanisamy 
Published: March 2013

ABSTRACTA sensitive and high‐throughput LC‐MS/MS method has been developed and validated for the combined determination of esomeprazole and naproxen in human plasma with ibuprofen as internal standard. Solid‐phase extraction was used to extract both analytes and internal standard from human plasma. Chromatographic separation was achieved in 4.0 min on XBridge C18 column using acetonitrile–25 mM ammonium formate (70:30, v/v) as mobile phase. Mass detection was achieved by ESI/MS/MS in negative ion mode, monitoring at m/z 344.19 → 194.12, 229.12 → 169.05 and 205.13 → 161.07 for esomeprazole, naproxen and IS, respectively. The calibration curves were linear from 3.00 to 700.02 ng/mL for esomeprazole and 0.50 to 150.08 ng/mL for naproxen. The intra‐ and inter‐batch precision and accuracy across four quality control levels met established criteria of US Food and Drug Administration guidelines. The assay is suitable for measuring accurate esomeprazole and naproxen plasma concentrations in human bioequivalence study following combined administration. Copyright © 2013 John Wiley & Sons, Ltd.
UPLC‐MS/MS assay for the simultaneous quantification of carvedilol and its active metabolite 4′‐hydroxyphenyl carvedilol in human plasma to support a bioequivalence study in healthy volunteers
Authors: Patel Daxesh P. , Sharma Primal , Sanyal Mallika , Singhal Puran , Shrivastav Pranav S. 
Published: March 2013

ABSTRACTAn ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) method has been developed for the simultaneous determination of carvedilol and its pharmacologically active metabolite 4′‐hydroxyphenyl carvedilol in human plasma using their deuterated internal standards (IS). Samples were prepared by solid‐phase extraction using 100 μL human plasma. Chromatographic separation of analytes was achieved on UPLC C18 (50 × 2.1 mm, 1.7 µm) column using acetonitrile‐4.0 mm ammonium formate, pH 3.0 adjusted with 0.1% formic acid (78:22, v/v) as the mobile phase. The multiple reaction monitoring transitions for both the analytes and IS were monitored in the positive electrospray ionization mode. The method was validated over a concentration range of 0.05–50 ng/mL for carvedilol and 0.01‐10 ng/mL for 4′‐hydroxyphenyl carvedilol. Intra‐ and inter‐batch precision (% CV) and accuracy for the analytes varied from 0.74 to 3.88 and 96.4 to 103.3% respectively. Matrix effect was assessed by post‐column analyte infusion and by calculation of precision values (coefficient of variation) in the measurement of the slope of calibration curves from eight plasma batches. The assay recovery was within 94–99% for both the analytes and IS. The method was successfully applied to support a bioequivalence study of 12.5 mg carvedilol tablets in 34 healthy subjects. Copyright © 2013 John Wiley & Sons, Ltd.
A Designed Three‐Stranded β‐Sheet in an α/β Hybrid Peptide
Authors: Sonti Rajesh , Gopi Hosahudya N. , Muddegowda Umashankara , Ragothama Srinivasarao , Balaram Padmanabhan 
Published: March 2013

AbstractThe incorporation of β‐amino acid residues into the antiparallel β‐strand segments of a multi‐stranded β‐sheet peptide is demonstrated for a 19‐residue peptide, Boc‐LVβFVDPGLβFVVLDPGLVLβFVV‐OMe (BBH19). Two centrally positioned DPro–Gly segments facilitate formation of a stable three‐stranded β‐sheet, in which β‐phenylalanine (βPhe) residues occur at facing positions 3, 8 and 17. Structure determination in methanol solution is accomplished by using NMR‐derived restraints obtained from NOEs, temperature dependence of amide NH chemical shifts, rates of H/D exchange of amide protons and vicinal coupling constants. The data are consistent with a conformationally well‐defined three‐stranded β‐sheet structure in solution. Cross‐strand interactions between βPhe3/βPhe17 and βPhe3/Val15 residues define orientations of these side‐chains. The observation of close contact distances between the side‐chains on the N‐ and C‐terminal strands of the three‐stranded β‐sheet provides strong support for the designed structure. Evidence is presented for multiple side‐chain conformations from an analysis of NOE data. An unusual observation of the disappearance of the Gly NH resonances upon prolonged storage in methanol is rationalised on the basis of a slow aggregation step, resulting in stacking of three‐stranded β‐sheet structures, which in turn influences the conformational interconversion between type I′ and type II′ β‐turns at the two DPro–Gly segments. Experimental evidence for these processes is presented. The decapeptide fragment Boc‐LVβFVDPGLβFVV‐OMe (BBH10), which has been previously characterized as a type I′ β‐turn nucleated hairpin, is shown to favour a type II′ β‐turn conformation in solution, supporting the occurrence of conformational interconversion at the turn segments in these hairpin and sheet structures.
Removal of Organic Dyes in Environmental Water onto Magnetic‐Sulfonic Graphene Nanocomposite
Authors: Wang Sui , Wei Jing , Lv Shasha , Guo Zhiyong , Jiang Feng 
Published: March 2013

AbstractA magnetic‐sulfonic graphene nanocomposite (G‐SO3H/Fe3O4) was synthesized and characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and X‐ray diffraction. It was used for removal of three cationic dyes: safranine T (ST), neutral red (NR), victoria blue (VB), and three anionic dyes: methyl orange, brilliant yellow, and alizarin red, from environmental water. The experimental conditions were optimized, including pH, amount of adsorbent, adsorption kinetics, adsorption isotherms, ionic strength, etc. The results show that G‐SO3H/Fe3O4 can adsorb cationic dyes more efficiently and selectively than anionic dyes at pH 6.0. In the first 10 min of adsorption time, more than 93% of the cationic dyes were removed by the sorbent. Adsorption kinetics follow the pseudo‐second‐order kinetic model well. The adsorption isotherm coincided with Langmuir and Freundlich adsorption models. The maximum adsorption capacities of G‐SO3H/Fe3O4 for ST, NR, and VB dyes were 199.3, 216.8, and 200.6 mg g−1. The adsorbed cationic dyes were eluted by using different pH values of ethanol as the solvent. The established method was simple, sensitive, and rapid, and was suitable for the adsorption of cationic dyes in environmental water.
Development of Bench‐Scale Bio‐Packed Column for Wastewater Treatment from Optical Emission Spectrometry
Authors: Vijayaraghavan Kuppusamy , Segovia Elvagris 
Published: March 2013

AbstractAn eco‐friendly and inexpensive technique for wastewater treatment originated from inductively coupled plasma‐optical emission spectrometry (ICP‐OES) is presented within this paper. The proposed process comprised of loading waste crab shells in packed column for adsorption of heavy metal ions, followed by desorption using 0.01 M HCl. An exhaustive physical and chemical characterization of ICP‐OES wastewater revealed the complex nature of effluent, including the presence of 15 different metals and metalloid under strong acidic condition (pH 1.3). Based on the preliminary batch experiments, it was identified that solution pH played a major role in metal sequestration by crab shell with pH 3.5 identified as optimum pH. Rapid metal biosorption kinetics along with complete desorption and subsequent reuse for three cycles was possible with crab shell‐based treatment process. Continuous flow‐through column experiments confirmed the high performance of crab shell towards multiple metal ions with the column able to operate for 22 h at a flow rate of 10 mL/min before outlet concentration of arsenic reached 0.25 times of its inlet concentration. Other metal ions such as Cu, Cd, Co, Cr, Pb, Ni, Zn, Mn, Al, and Fe were only in trace levels in the treated water until 22 h. The performance of the treatment process was compared with trade effluent discharge standards, and the process flow diagram along with cost analysis was suggested.
Preparation of Fluorescent Tubulin Binders
Authors: Riva Elena , Mattarella Martin , Borrelli Stella , Christodoulou Michael S. , Cartelli Daniele , Main Marcus , Faulkner Stephen , Sykes Daniel , Cappelletti Graziella , Snaith John S. , Passarella Daniele 
Published: March 2013

AbstractInvited for this month’s cover are the groups of Prof. Daniele Passarella, Prof. Graziella Cappelletti, Dr. Stephen Faulkner and Prof. John S. Snaith based at the Universities of Milano, Oxford and Birmingham. The image shows that a fluorescent tubulin binder could evidence the tubulin/microtubule network.
Emulsion‐Templated Macroporous Carbons Synthesized By Hydrothermal Carbonization and their Application for the Enzymatic Oxidation of Glucose
Authors: Brun Nicolas , Edembe Lise , Gounel Sébastien , Mano Nicolas , Titirici Magdalena M. 
Published: March 2013

AbstractCarbon‐based monoliths have been designed using a simple synthetic pathway based on using high internal phase emulsion (HIPE) as a soft template to confine the polymerization and hydrothermal carbonization of saccharide derivatives (furfural) and phenolic compounds (phloroglucinol). Monosaccharides can be isolated from the cellulosic fraction of lignocellulosic biomass and phloroglucinol can be extracted from the bark of fruit trees; however, this approach constitutes an interesting sustainable synthetic route. The macroscopic characteristics can be easily modulated; a high macroporosity and total pore volume of up to 98 % and 18 cm3 g−1 have been obtained, respectively. After further thermal treatment under inert atmosphere, the as‐synthesized macroporous carbonized HIPEs (carbo‐HIPEs) have shaping capabilities relating to interesting mechanical properties as well as a high electrical conductivity of up to 300 S m−1. These conductive foams exhibit a hierarchical structure associated with the presence of both meso‐ and micropores that exhibit specific Brunauer–Emmett–Teller (BET) surface areas and DFT total pore volumes up to 730 m2 g−1 and 0.313 cm3 g−1, respectively. Because of their attractive structural characteristics and intrinsic properties, these macroporous monoliths have been incorporated as a proof of principle within electrochemical devices as modified thin carbon disc electrodes. A promising two‐fold improvement in the catalytic current is observed for the electrooxidation of glucose after the immobilization of a glucose oxidase‐based biocatalytic mixture onto the carbo‐HIPE electrodes compared to that observed if using commercial glassy carbon electrodes.
Solid‐State NMR Spectroscopic Studies of Propylphosphonic Acid Functionalized SBA‐15 Mesoporous Silica: Characterization of Hydrogen‐Bonding Interactions
Authors: Bibent Nicolas , Charpentier Thibault , Devautour‐Vinot Sabine , Mehdi Ahmad , Gaveau Philippe , Henn François , Silly Gilles 
Published: March 2013

AbstractThis work aims to investigate the local structure of mesoporous silica of the type SBA‐15 functionalized with propylphosphonic acid groups by means of an extensive solid‐state NMR spectroscopic study. Here, the functionalized SBA‐15 samples are obtained by a one‐step synthetic method that allowed us better control over the loading and the distribution of the surface functions. In addition to NMR spectroscopy, the materials are characterized by X‐ray diffraction, nitrogen adsorption–desorption and transmission electron microscopy. The 29Si, 13C, 31P and 1H one‐dimensional NMR spectroscopic results are discussed according to the nature of the functional groups in dry and wet materials. This paper proposes a rigorous approach that shows possible hydrogen bonding between adjacent phosphonic acid groups in dry SBA‐15, from the comparative study with an alkylphosphonic acid material. This outcome was demonstrated by two‐dimensional NMR spectroscopic solid–state experiments, including the use of 1H–1H spin‐diffusion exchange experiments, 31P–31P double quanta and an original pulse sequence that corresponds to 31P–1H–1H–31P correlation experiments.