bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectory of haemoglobin A1c and incidence of cardiovascular disease in patients with type 2 diabetes mellitus
Authors: Wang Yuan , Chin Weng Yee , Lam Cindy Lo Kuen , Wan Eric Yuk Fai 
Published: August 2024

AbstractAimTo evaluate the association between changes in haemoglobin A1c (HbA1c) and the concurrent incidence of cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM) patients.MethodWe conducted a retrospective cohort study among T2DM patients with HbA1c measurement after T2DM diagnosis between August 2009 and September 2010. The patients were classified into six subgroups based on baseline HbA1c (<7%; 7%–7.9%; ≥8%) and age (<65; ≥65 years), and then clustered into classes by HbA1c trajectory and CVD incidence over the 12‐year follow‐up period using joint latent class mixture models. We explored the HbA1c trajectories and CVD incidences in each latent class. Multinomial logistic regression was used to compare the baseline characteristics among different latent classes.ResultsA total of 128 843 T2DM patients were included with a median follow‐up period of 11.7 years. Ten latent classes were identified in patients with baseline HbA1c ≥ 8% and age <65 years, while seven classes were identified in the other five groups. Among all the identified latent classes, patients with fluctuating HbA1c trajectories, characterized by alternating periods of increase and decrease, had higher CVD incidences. Male patients, and patients with higher baseline HbA1c and use of antidiabetic drugs were more likely to have a fluctuating HbA1c trajectory. More specifically, patients aged < 65 years with younger age or a smoking habit, and patients aged ≥ 65 years with a longer duration of T2DM were more likely to have a fluctuating HbA1c trajectory.ConclusionWe found that T2DM patients with fluctuating HbA1c trajectories could have a higher CVD risk. Different trajectory‐associated characteristics in age subgroups highlight the need for individualized management of T2DM patients.
Association between glucagon‐like peptide‐1 receptor agonists and risk of suicidality: A comprehensive analysis of the global pharmacovigilance database
Authors: Kim Tae Hyeon , Lee Kyeongmin , Park Seoyoung , Cho Hanseul , Park Jaeyu , Jo Hyesu , Son Yejun , Kim Soeun , Kang Jiseung , Smith Lee , Rahmati Masoud , Fond Guillaume , Boyer Laurent , Pizzol Damiano , Lee Hayeon , Rhee Sang Youl , Hwang Jiyoung , Sang Hyunji , Yon Dong Keon 
Published: August 2024

AbstractAimTo evaluate the potential association between suicidality and glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), as well as other medications used for obesity and diabetes, using comprehensive global data.Materials and MethodsThis study utilized the World Health Organization's pharmacovigilance database, encompassing adverse drug reaction reports from 1967 to 2023, from 170 countries (total reports, N = 131 255 418). We present the reported odds ratios (RORs) with 95% confidence intervals (CIs) and information component (IC) with IC025 regarding the association between GLP‐1RA use and suicidality.ResultsAlthough reports of GLP‐1RA‐associated suicidality increased gradually from 2005 to 2023 (n = 332), no evidence of an association was observed (ROR 0.15 [95% CI 0.13 to 0.16]; IC −2.77 [IC025 −2.95]). The lack of evidence of an association persisted regardless of whether GLP‐1RAs were used for diabetes treatment (ROR 0.13 [95% CI 0.11 to 0.14]; IC −2.95 [IC025 −3.14]) or obesity treatment (ROR 0.44 [95% CI 0.34 to 0.58]; IC −1.16 [IC025 −1.62]). However, an association was found between suicidality and other diabetes medications excluding GLP‐1RAs (ROR 1.13 [95% CI 1.10 to 1.15]; IC 0.17 [IC025 0.13]). Similarly, the potential association with suicidality was observed in medications used to treat obesity excluding GLP‐1RAs (ROR 1.08 [95% CI 1.01 to 1.14]; IC 0.10 [IC025 0.01]).ConclusionsThe suspected association between GLP‐1RA use and suicidality, as raised by the European Medicines Agency, was not found in our global analysis. This indicates that the sporadic reports of GLP‐1RA‐associated suicidality are likely influenced by factors such as comorbidities present in the GLP‐1RA user population.
Decoding the neural impact of radical complexity in Chinese characters during working memory task
Authors: Li Hongli , Zhao Xin 
Published: August 2024

AbstractReaders of Chinese characters need to recognize how they are formed in order to identify them correctly. However, our understanding of the cognitive processing of characters in working memory is limited. In Experiment 1, using the character N‐back task paradigm, electrophysiological data were recorded from 26 participants to investigate the effects of the visual feature of radicals on neural activity during the character recognition, updating and maintenance in the N‐back task. Results showed that compound characters required longer response times than single‐component characters. For the event‐related potentials (ERPs), the compound character condition had more negative N2pc and lower P300 amplitudes than the single‐component character condition. In Experiment 2, data from 26 participants were used to analyse the effect of the phonological feature of radicals on neural activity during the character recognition, updating and maintenance in the N‐back task. Results showed that there was a larger P200 in the irregular character condition than in the regular character condition, but there was no difference between the regular and the irregular characters in the N2pc, P300 and slow wave (SW) components. The visual feature and the phonological feature of the radicals may have different effects on the character processing. This study reveals the neural effects of Chinese character radicals on cognitive processing in a working memory task and provides behavioural and electrophysiological evidence for a theoretical model of verbal working memory subprocesses.
Substantial contribution of inorganic carbon sources to CO2 emissions in calcareous vineyard soils in Germany
Authors: Islam Muhammad , Wehrle Ralf , Pätzold Stefan , Brüggemann Nicolas 
Published: August 2024

AbstractIn light of climate change and increasing global temperatures, it is important to equally prioritize the study of inorganic carbon dynamics in calcareous soils within temperate ecosystems, as has been done for arid or semiarid environments. A significant area of vineyards in Germany is established on calcareous soils. However, the potential influence of inorganic carbon on CO2 emissions in these vineyards has not been sufficiently explored when evaluating the carbon footprint of management practices in relation to carbon storage. Therefore, we aimed to differentiate between organic and inorganic sources of CO2 emissions from six vineyard soils located in the southwest of Germany that had previously received organic soil amendments (OA). Inorganic carbon content varied between 8 and 55 g kg−1 across different sites, with variations observed in the inorganic‐to‐organic carbon ratio. Soil samples were incubated under standard laboratory conditions for 48 h, and the source of emitted CO2 was determined using a two‐end‐member mixing model. The contribution of inorganic carbon to CO2 emissions was influenced by the quantity of inorganic carbon, with an increase in contribution with increasing inorganic‐to‐organic carbon ratio. On average, abiotic sources accounted for 5% to 40% of the emitted CO2 at the different sites, with one site showing no significant contribution of inorganic carbon. CO2 production from inorganic carbon was higher in the subsoil compared with the topsoil, likely related to the higher content of inorganic carbon in the subsoil. Notably, there was no discernible influence of OA on carbonate dissolution. This study emphasizes the significance of considering abiotic sources of CO2 emissions in addition to soil respiration in calcareous soils and highlights the need for further investigation to apply these findings at the field scale.
Combined value of interictal markers and stimulated seizures to estimate the seizure onset zone in stereoelectroencephalography
Authors: Rekola Lauri , Peltola Maria , Vanhanen Jukka , Wilenius Juha , Metsähonkala Eeva‐Liisa , Kämppi Leena , Lauronen Leena , Nevalainen Päivi 
Published: August 2024

AbstractObjectiveThis study was undertaken to investigate the potential of interictal electroencephalographic (EEG) findings and electrically stimulated seizures during stereo‐EEG (SEEG) as surrogate markers for the spontaneous seizure onset zone (spSOZ). We hypothesized that combining the localizing information of these markers would allow clinically meaningful estimation of the spSOZ.MethodsWe included all patients (n = 63) who underwent SEEG between January 2013 and March 2020 at Helsinki University Hospital and had spontaneous seizures during the recording. We scored spikes, gamma activity, and background abnormality on each channel visually during a 12‐h epoch containing waking state and sleep. Based on semiology, we classified stimulated seizures as typical or atypical/unclassifiable and estimated the stimulated SOZ (stimSOZ) for typical seizures. To assess which markers increased the odds of channel inclusion in the spSOZ, we fitted mixed effects logistic regression models.ResultsA combined regression model including the stimSOZ and interictal markers scored during sleep performed better in estimating which channels were part of the spSOZ than models based on stimSOZ (p < .001) or interictal markers (p < .001) alone. Of the individual markers, the effect sizes were greatest for inclusion of a channel in the stimSOZ (odds ratio [OR] = 60, 95% confidence interval [CI] = 37–97, p < .001) and for continuous (OR = 25, 95% CI = 12–55, p < .001) and subcontinuous (OR = 36, 95% CI = 21–64, p < .001) interictal spiking. At the individual level, the model's accuracy to predict spSOZ inclusion varied markedly (median accuracy = 85.7, range = 54.4–100), which was not explained by etiology (p > .05).SignificanceCompared to either marker alone, combining visually rated interictal SEEG markers and stimulated seizures improved prediction of which SEEG channels belonged to the spSOZ. Inclusion in the stimSOZ and continuous or subcontinuous spikes increased the odds of spSOZ inclusion the most. Future studies should investigate whether suboptimal sampling of the true epileptogenic zone can explain the model's poor performance in certain patients.
High‐gamma modulation language mapping and cognitive outcomes after epilepsy surgery
Authors: Ervin Brian , Kargol Christina , Byars Anna W. , Buroker Jason , Rozhkov Leonid , Skoch Jesse , Mangano Francesco T. , Greiner Hansel M. , Horn Paul S. , Holland Katherine , Arya Ravindra 
Published: August 2024

AbstractObjectiveWe evaluated changes in cognitive domains after neurosurgical lesioning of cortical sites with significant high‐gamma power modulations (HGM) during a visual naming task, although these sites were found language‐negative on standard‐of‐care electrical stimulation mapping (ESM).MethodsIn drug‐resistant epilepsy patients who underwent resection/ablation after stereo‐electroencephalography (SEEG), we computed reliable change indices (RCIs) from a battery of presurgical and 1‐year postsurgical neuropsychological assessments. We modeled RCIs as a function of lesioning even one HGM language site, number of HGM language sites lesioned, and the magnitude of naming‐related HGM. The analyses were adjusted for 1‐year seizure freedom, operated hemispheres, and the volumes of surgical lesions.ResultsIn 37 patients with 4455 SEEG electrode contacts (1839 and 2616 contacts in right and left hemispheres, respectively), no ESM language sites were lesioned. Patients with lesioning of even one HGM language site showed significantly lower RCIs for Peabody Picture Vocabulary Test (PPVT), working memory, and verbal learning immediate (VLI) scores. RCI declines with higher number of HGM language sites lesioned were seen in PPVT (slope [β] = −.10), working memory (β = −.10), VLI (β = −.14), and letter–word identification (LWI; β = −.14). No neuropsychological domains improved after lesioning of HGM language sites. Significant effects of the HGM magnitude at lesioned sites were seen on working memory (β = −.31), story memory immediate (β = −.27), verbal learning recognition (β = −.18), LWI (β = −.16), spelling (β = −.49), and passage comprehension (β = −.33). Because working memory was significantly affected in all three analyses, patients with maximal working memory decline were examined post hoc, revealing that all such patients had HGM naming sites lesioned in the posterior quadrants of either hemisphere.SignificanceHGM language mapping should be used as an adjunct to ESM in clinical practice and may help counsel patients/families about postsurgical cognitive deficits.
Linked Selection and Gene Density Shape Genome‐Wide Patterns of Diversification in Peatmosses
Authors: Meleshko Olena , Martin Michael D. , Flatberg Kjell Ivar , Stenøien Hans K. , Korneliussen Thorfinn Sand , Szövényi Péter , Hassel Kristian 
Published: August 2024

ABSTRACTGenome evolution under speciation is poorly understood in nonmodel and nonvascular plants, such as bryophytes—the largest group of nonvascular land plants. Their genomes are structurally different from angiosperms and likely subjected to stronger linked selection pressure, which may have profound consequences on genome evolution in diversifying lineages, even more so when their genome architecture is conserved. We use the highly diverse, rapidly radiated group of peatmosses (Sphagnum) to characterize the processes affecting genome diversification in bryophytes. Using whole‐genome sequencing data from populations of 12 species sampled at different phylogenetic and geographical scales, we describe high correlation of the genomic landscapes of differentiation, divergence, and diversity in Sphagnum. Coupled with evidence from the patterns of covariation among different measures of genetic diversity, phylogenetic discordance, and gene density, this provides strong support that peatmoss genome evolution has been shaped by the long‐term effects of linked selection, constrained by distribution of selection targets in the genome. Thus, peatmosses join the growing number of animal and plant groups where functional features of the genome, such as gene density, and linked selection drive genome evolution along predetermined and highly similar routes in different species. Our findings demonstrate the great potential of bryophytes for studying the genomics of speciation and highlight the urgent need to expand the genomic resources in this remarkable group of plants.
Trends in the management of horses referred for colic evaluation preceding and during the COVID‐19 pandemic (2013–2023)
Authors: Elane George L. , Blikslager Anthony T. , Mair Tim S. 
Published: August 2024

SummaryBackgroundThe COVID‐19 pandemic represented a significant source of anxiety and stress for equine veterinarians and clients, with the potential for measurable effects on caseload and owner economics.ObjectiveTo compare the number of horses presenting for emergency colic evaluation and treatment, as well as costs at two equine referral hospitals.Study designRetrospective cohort.MethodsMedical records of horses admitted to North Carolina State University (NCSU) and Bell Equine Veterinary Clinic (BEVC) were compared. Total equine accessions, number of horses referred for colic and patient age were recorded over an 11‐year period (2013–2023). Horses were categorised based on treatment as medical, surgical treatment with recovery, surgical exploration with intraoperative euthanasia, or euthanasia without surgery. Total invoice of each case was also recorded.ResultsTotal equine accessions, total number and proportion of horses presenting for evaluation of colic, and number of horses recovering from colic surgery at NCSU increased following onset of the pandemic, while they remained similar to pre‐pandemic levels at BEVC. The proportion of horses presenting for colic that received surgery decreased at both hospitals over the study period. Mean invoice totals for horses surviving colic surgery increased at both hospitals over the study period, but was not significantly associated with euthanasia. Age was not significantly different between categories of colic.Main limitationsRetrospective study design, differences in academic and private practices.ConclusionsThe decreasing proportion of horses admitted for colic that received surgery is likely due to the increased caseload of first‐opinion care at referral practices during the pandemic, as fewer options were available to owners. The increasing number of horses euthanised intraoperatively or euthanised without receiving surgery may be due to the dramatically rising costs of medical care, particularly surgery.
Net primary productivity and litter decomposition rates in two distinct Amazonian peatlands
Authors: Dargie G. C. , del Aguila‐Pasquel J. , Córdova Oroche C. J. , Irarica Pacaya J. , Reyna Huaymacari J. , Baker T. R. , Hastie A. , Honorio Coronado E. N. , Lewis S. L. , Roucoux K. H. , Mitchard E. T. , Williams M. , Draper F. C. H. , Lawson I. T. 
Published: August 2024

AbstractMeasurements of net primary productivity (NPP) and litter decomposition from tropical peatlands are severely lacking, limiting our ability to parameterise and validate models of tropical peatland development and thereby make robust predictions of how these systems will respond to future environmental and climatic change. Here, we present total NPP (i.e., above‐ and below‐ground) and decomposition data from two floristically and structurally distinct forested peatland sites within the Pastaza Marañón Foreland Basin, northern Peru, the largest tropical peatland area in Amazonia: (1) a palm (largely Mauritia flexuosa) dominated swamp forest and (2) a hardwood dominated swamp forest (known as ‘pole forest’, due to the abundance of thin‐stemmed trees). Total NPP in the palm forest and hardwood‐dominated forest (9.83 ± 1.43 and 7.34 ± 0.84 Mg C ha−1 year−1, respectively) was low compared with values reported for terra firme forest in the region (14.21–15.01 Mg C ha−1 year−1) and for tropical peatlands elsewhere (11.06 and 13.20 Mg C ha−1 year−1). Despite the similar total NPP of the two forest types, there were considerable differences in the distribution of NPP. Fine root NPP was seven times higher in the palm forest (4.56 ± 1.05 Mg C ha−1 year−1) than in the hardwood forest (0.61 ± 0.22 Mg C ha−1 year−1). Above‐ground palm NPP, a frequently overlooked component, made large contributions to total NPP in the palm‐dominated forest, accounting for 41% (14% in the hardwood‐dominated forest). Conversely, Mauritia flexuosa litter decomposition rates were the same in both plots: highest for leaf material, followed by root and then stem material (21%, 77% and 86% of mass remaining after 1 year respectively for both plots). Our results suggest potential differences in these two peatland types' responses to climate and other environmental changes and will assist in future modelling studies of these systems.
Beyond resilience: Responses to changing climate and disturbance regimes in temperate forest landscapes across the Northern Hemisphere
Authors: Dollinger Christina , Rammer Werner , Suzuki Kureha F. , Braziunas Kristin H. , Keller Timon T. , Kobayashi Yuta , Mohr Johannes , Mori Akira S. , Turner Monica G. , Seidl Rupert 
Published: August 2024

AbstractClimate change has profound impacts on forest ecosystem dynamics and could lead to the emergence of novel ecosystems via changes in species composition, forest structure, and potentially a complete loss of tree cover. Disturbances fundamentally shape those dynamics: the prevailing disturbance regime of a region determines the inherent variability of a system, and its climate‐mediated change could accelerate forest transformation. We used the individual‐based forest landscape and disturbance model iLand to investigate the resilience of three protected temperate forest landscapes on three continents—selected to represent a gradient from low to high disturbance activity—to changing climate and disturbance regimes. In scenarios of sustained strong global warming, natural disturbances increased across all landscapes regardless of projected changes in precipitation (up to a sevenfold increase in disturbance rate over the 180‐year simulation period). Forests in landscapes with historically high disturbance activity had a higher chance of remaining resilient in the future, retaining their structure and composition within the range of variability inherent to the system. However, the risk of regime shift and forest loss was also highest in these systems, suggesting forests may be vulnerable to abrupt change beyond a threshold of increasing disturbance activity. Resilience generally decreased with increasing severity of climate change. Novelty in tree species composition was more common than novelty in forest structure, especially under dry climate scenarios. Forests close to the upper tree line experienced high novelty in structure across all three study systems. Our results highlight common patterns and processes of forest change, while also underlining the diverse and context‐specific responses of temperate forest landscapes to climate change. Understanding past and future disturbance regimes can anticipate the magnitude and direction of forest change. Yet, even across a broad gradient of disturbance activity, we conclude that climate change mitigation is the most effective means of maintaining forest resilience.
An invasive prey and changing climate interact to shape the breeding phenology of an endangered predator
Authors: Fletcher Robert J. , Beatty Meghan A. , Elmquist Lara , Jeffery Brian M. , Poli Caroline L. , Robertson Ellen P. 
Published: August 2024

AbstractChanges in phenology are occurring from global climate change, yet the impacts of other types of global change on the phenology of animals remain less appreciated. Understanding the potential for synergistic effects of different types of global change on phenology is needed, because changing climate regimes can have cascading effects, particularly on invasive species that vary in their thermal tolerances. Using 25 years of data from 5963 nests and 4675 marked individuals across the entire US breeding range of an endangered predator, the snail kite (Rostrhamus sociabilis plumbeus), we isolated the effects of an invasion of novel prey and warming temperatures on breeding phenology and its demographic consequences. Over this time period, breeding season length doubled, increasing by approximately 14 weeks. Both temperature and the establishment of invasive prey interacted to explain the timing of nest initiation. Temperature and invasive prey played distinct roles: earlier nest initiation occurred with increasing temperatures, whereas late nesting increased with invasion. Ultimately, both nest survival and juvenile survival declined later in the year, such that effects from invasive prey, but not warming temperatures, have the apparent potential for mistiming in breeding phenology by some individuals. Nonetheless, relatively few nesting events occurred during late fall when nest survival was very low, and seasonal declines in nest survival were weaker and renesting was more frequent in invaded wetlands, such that total reproductive output increased with invasion. Variation in demographic effects illustrate that considering only particular components of demography (e.g., nest survival rates) may be inadequate to infer the overall consequences of changes in phenology, particularly the potential for mistiming of phenological events. These results emphasize that species invasions may profoundly alter phenology of native species, such effects are distinct from climate effects, and both interact to drive population change.