bluuebunny/crossref_metadata_2025_split huggingface dataset:
Criterion validity of the general factor of psychopathology in a prospective study of girls
Authors: Lahey Benjamin B. , Rathouz Paul J. , Keenan Kate , Stepp Stephanie D. , Loeber Rolf , Hipwell Alison E. 
Published: July 2014

BackgroundThe best‐fitting model of the structure of common psychopathology often includes a general factor on which all dimensions of psychopathology load. Such a general factor would be important if it reflects etiologies and mechanisms shared by all dimensions of psychopathology. Nonetheless, a viable alternative explanation is that the general factor is partly or wholly a result of common method variance or other systematic measurement biases.MethodsTo test this alternative explanation, we extracted general, externalizing, and internalizing factor scores using mother‐reported symptoms across 5–11 years of age in confirmatory factor analyses of data from a representative longitudinal study of 2,450 girls. Independent associations between the three psychopathology factor scores and teacher‐reported criterion variables were estimated in multiple regression, controlling intelligence, and demographic covariates.ResultsThe model including the general factor fit significantly better than a correlated two‐factor (internalizing/externalizing) model. The general factor was robustly and independently associated with all measures of teacher‐reported school functioning concurrently during childhood and prospectively during adolescence.ConclusionsThese findings weaken the hypothesis that the general factor of psychopathology in childhood is solely a measurement artifact and support further research on the substantive meaning of the general factor.
Differential regulation of amyloid precursor protein sorting with pathological mutations results in a distinct effect on amyloid‐β production
Authors: Lin Yen‐Chen , Wang Jia‐Yi , Wang Kai‐Chen , Liao Jhih‐Ying , Cheng Irene H. 
Published: July 2014

AbstractThe deposition of amyloid‐β (Aβ) peptide, which is generated from amyloid precursor protein (APP), is the pathological hallmark of Alzheimer's disease (AD). Three APP familial AD mutations (D678H, D678N, and H677R) located at the sixth and seventh amino acid of Aβ have distinct effect on Aβ aggregation, but their influence on the physiological and pathological roles of APP remain unclear. We found that the D678H mutation strongly enhances amyloidogenic cleavage of APP, thus increasing the production of Aβ. This enhancement of amyloidogenic cleavage is likely because of the acceleration of APPD678H sorting into the endosomal‐lysosomal pathway. In contrast, the APPD678N and APPH677R mutants do not cause the same effects. Therefore, this study indicates a regulatory role of D678H in APP sorting and processing, and provides genetic evidence for the importance of APP sorting in AD pathogenesis.image
The internalization of amyloid precursor protein (APP) increases its opportunity to be processed by β‐secretase and to produce Amyloid‐β (Aβ) that causes Alzheimer's disease (AD). We report a pathogenic APPD678H mutant that enhances APP internalization into the endosomal‐lysosomal pathway and thus promotes the β‐secretase cleavage and Aβ production. This study provides genetic evidence for the importance of APP sorting in AD pathogenesis.
Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats
Authors: Hassler Shayne N. , Johnson Kathia M. , Hulsebosch Claire E. 
Published: July 2014

AbstractChronic neuropathic pain is a common consequence of spinal cord injury (SCI), develops over time and negatively impacts quality of life, often leading to substance abuse and suicide. Recent evidence has demonstrated that reactive oxygen species (ROS) play a role in contributing to neuropathic pain in SCI animal models. This investigation examines four compounds that reduce ROS and the downstream lipid peroxidation products, apocynin, 4‐oxo‐tempo, U‐83836E, and tirilazad, and tests if these compounds can reduce nocioceptive behaviors in chronic SCI animals. Apocynin and 4‐oxo‐tempo significantly reduced abnormal mechanical hypersensitivity measured in forelimbs and hindlimbs in a model of chronic SCI‐induced neuropathic pain. Thus, compounds that inhibit ROS or lipid peroxidation products can be used to ameliorate chronic neuropathic pain.
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We propose that the application of compounds that inhibit reactive oxygen species (ROS) and related downstream molecules will also reduce the behavioral measures of chronic neuropathic pain. Injury or trauma to nervous tissue leads to increased concentrations of ROS in the surviving tissue. Further damage from ROS molecules to dorsal lamina neurons leads to membrane excitability, the physiological correlate of chronic pain. Chronic pain is difficult to treat with current analgesics and this research will provide a novel therapy for this disease.
CLIC1 functional expression is required for cAMP‐induced neurite elongation in post‐natal mouse retinal ganglion cells
Authors: Averaimo Stefania , Gritti Marta , Barini Erica , Gasparini Laura , Mazzanti Michele 
Published: July 2014

AbstractDuring neuronal differentiation, axonal elongation is regulated by both external and intrinsic stimuli, including neurotropic factors, cytoskeleton dynamics, second messengers such as cyclic adenosine monophosphate (cAMP), and neuronal excitability. Chloride intracellular channel 1 (CLIC1) is a cytoplasmic hydrophilic protein that, upon stimulation, dimerizes and translocates to the plasma membrane, where it contributes to increase the membrane chloride conductance. Here, we investigated the expression of CLIC1 in primary hippocampal neurons and retinal ganglion cells (RGCs) and examined how the functional expression of CLIC1 specifically modulates neurite outgrowth of neonatal murine RGCs. Using a combination of electrophysiology and immunohistochemistry, we found that CLIC1 is expressed in hippocampal neurons and RGCs and that the chloride current mediated by CLIC1 is required for maintaining growth cone morphology and sustaining cAMP‐stimulated neurite elongation in dissociated immunopurified RGCs. In cultured RGCs, inhibition of CLIC1 ionic current through the pharmacological blocker IAA94 or a specific anti‐CLIC1 antibody directed against its extracellular domain prevents the neurite outgrowth induced by cAMP. CLIC1‐mediated chloride current, which results from an increased open probability of the channel, is detected only when cAMP is elevated. Inhibition of protein kinase A prevents such current. These results indicate that CLIC1 functional expression is regulated by cAMP via protein kinase A and is required for neurite outgrowth modulation during neuronal differentiation.
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Using a combination of electrophysiology and immunohistochemistry, we found that the chloride intracellular channel 1 (CLIC1) protein modulates the speed of neurite growth. The chloride current mediated by CLIC1 is essential for maintaining growth cone morphology and is required for sustaining cAMP‐stimulated neurite elongation in dissociated immunopurified neurons. The presence of either the CLIC1 current blocker IAA94 or the anti‐CLIC1 antibody inhibits neurite growth of Retina Ganglion Cells cultured in the presence of 10 micromolar forskolin for 24 h.
Could mean platelet volume in late first trimester of pregnancy predict intrauterine growth restriction and pre‐eclampsia?
Authors: Kanat‐Pektas Mine , Yesildager Ufuk , Tuncer Nadire , Arioz Dagistan T. , Nadirgil‐Koken Gulengul , Yilmazer Mehmet 
Published: July 2014

AbstractAimThe present study aims to determine whether mean platelet volume (MPV) specified in late first trimester of pregnancy can be used to predict pre‐eclampsia and intrauterine growth restriction (IUGR).MethodsThis study prospectively reviews 200 healthy women with 11–14‐week‐old pregnancies.ResultsAverage pregnancy‐associated plasma protein‐A (PAPP‐A) multiples of the median (MoM) value was significantly lower and MPV was significantly higher in pre‐eclamptic pregnancies (P = 0.001 for both). MPV values of 10.5 fl or more can predict pre‐eclampsia with 66.7% sensitivity and 63.8% specificity. The combination of MPV of 10.5 fl or more and PAPP‐A MoM of 0.33 or less can predict pre‐eclampsia with 75% sensitivity and 70.0% specificity. MPV values of 10.5 fl or more can predict IUGR with 82.4% sensitivity and 60.0% specificity. The combination of MPV of 10.5 fl or more and PAPP‐A MoM of 0.33 or less can predict IUGR with 85.3% sensitivity and 62.0% specificity.ConclusionIncreased MPV reflects enhanced platelet activation which may be caused by impairment in uteroplacental circulation. When MPV of 10.1 or more and PAPP‐A MoM of 0.33 or less are combined as a threshold, the pregnancies that are destined to develop IUGR and pre‐eclampsia can be predicted with considerably high sensitivity and specificity. The MPV and PAPP‐A combination can be addressed as a useful biochemical tool for the prediction of IUGR and pre‐eclampsia in late first trimester.
Prediction of histological types of endometrial cancer by endometrial cytology
Authors: Okadome Masao , Saito Toshiaki , Nishiyama Naoko , Ariyoshi Kazuya , Shimamoto Kumi , Shimada Takako , Kodama Keisuke , Imamura Shogo , Nishiyama Ken‐ichi , Taguchi Kenichi 
Published: July 2014

AbstractAimFew studies have examined the accuracy of preoperative endometrial cytology in diagnosing low‐ and high‐risk histology in women with endometrial cancer (EC). This single‐institutional retrospective study compared the accuracy of endometrial cytology and biopsy in preoperatively predicting low‐risk and high‐risk histology of EC.MethodsBetween January 2006 and March 2013, 198 women with EC were examined by endometrial cytology, endometrial biopsy and hysterectomy specimen in National Kyushu Cancer Center. Among these women, 110 had endometrial cytology samples available to compare with endometrial biopsy, and were enrolled in our study (mean age ± standard deviation: 59.57 ± 10.32 years). Single‐use plastic endometrial suction curettes were used in 12 of the 110 cases and thin metallic curettes for the rest.ResultsFor type 2 EC, which includes grade 3 endometrioid adenocarcinoma and non‐endometrioid histology, biopsy was 67.6% sensitive (25/37) and 84.9% specific (62/73); whereas cytology was 70.3% sensitive (26/37) and 91.8% specific (67/73). Cytology precisely diagnosed only one of 14 cases of serous carcinoma, but it diagnosed 11 of the 14 cases as type 2 EC, and its accuracy in distinguishing EC types was not inferior to endometrial biopsy (10/14). For EC, 9.1% (10/110) were unevaluable using biopsy, significantly more than the 0% (0/110) by cytology (P = 0.002).ConclusionAlthough preoperative prediction of serous carcinoma was difficult, endometrial cytology had a higher evaluable rate for EC types. Endometrial cytology may complement endometrial biopsy in preoperative women with EC.
Prenatal differential diagnosis of complete hydatidiform mole with a twin live fetus and placental mesenchymal dysplasia by magnetic resonance imaging
Authors: Himoto Yuki , Kido Aki , Minamiguchi Sachiko , Moribata Yusaku , Okumura Ryosuke , Mogami Haruta , Nagano Tadayoshi , Konishi Ikuo , Togashi Kaori 
Published: July 2014

AbstractAimTo assess the use of magnetic resonance imaging (MRI) for prenatal differentiation between complete hydatidiform mole with a twin live fetus (CHMTF) and placental mesenchymal dysplasia (PMD).MethodsThree CHMTF cases and three PMD cases, from two institutions over a 6‐year period, were retrospectively included in this study. Clinical findings including age, pregnancy history, serum hCG level, ultrasonography findings, complications of the mother, outcome of the fetus, and results of chromosomal study of fetus, amniotic fluid and lesion, if possible, were noted. MRI findings were evaluated by two radiologists with respect to the location of the disease (intra‐ or extra‐fetal sac), the presence of multicystic component, and presence of intra‐ or extra‐lesional hemorrhage.ResultsIn all six cases, the diseases were recognized as multicystic lesions by ultrasonography and MRI. In two of three CHMTF cases, patients continued with the pregnancy, which resulted in spontaneous abortion. In one case of CHMTF, the patient underwent artificial abortion, after which the mole progressed into an invasive mole with lung metastases. All three PMD patients had live births, and two of the three babies had fetal growth restriction. By MRI, CHMTF was located within an extra‐fetal sac accompanied by intra‐ and/or extra‐lesional hemorrhage, while PMD was located within the placenta in the fetal sac without hemorrhage.ConclusionMRI could provide important information about the prenatal differential diagnosis of CHMTF and PMD, based on the pathophysiology and characteristics of the diseases.
Role of postprandial bile acids in prediction of perinatal outcome in intrahepatic cholestasis of pregnancy
Authors: Sargın Oruç Ayla , Seçkin Berna , Özcan Nagihan , Özyer Sebnem , Uzunlar Özlem , Danışman Nuri 
Published: July 2014

AbstractAimThe aim of this study was to investigate the role of fasting and postprandial total bile acids (fTBA, ppTBA) in prediction of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy (ICP).Material and MethodsA total of 111 patients, 57 with ICP and 54 controls, were evaluated for preterm birth (PTB), meconium‐stained amnion (MSA), neonatal intensive‐care unit admission and asphyxia. We further classified the ICP group as mild and severe. Logistic regression was performed to evaluate the associated biochemical and clinical parameters with adverse perinatal outcomes.ResultsIn the ICP group, PTB, asphyxia, admission to neonatal intensive‐care unit, and MSA were more frequently observed (P = 0.001, P = 0.027, P = 0.006 and P = 0.030, respectively). In subgroup analysis, PTB was more frequent in severe ICP cases than in mild cases (P = 0.028). Fasting and ppTBA were positively correlated with serum aspartate aminotransferase and alanine aminotransferase levels. Postprandial TBA and difference between fasting and postprandial TBA levels were associated with asphyxia (P = 0.014 and P = 0.023, respectively). Gestational age at diagnosis and fTBA were associated with adverse perinatal outcomes (P = 0.001 and P = 0.025, respectively).ConclusionPostprandial TBA and difference of fasting and postprandial TBA are associated with asphyxia in ICP. The gestational age at diagnosis and fTBA are associated with adverse perinatal outcomes.
Concentrated ascites re‐infusion therapy for pseudo‐Meigs' syndrome complicated by massive ascites in large pedunculated uterine leiomyoma
Authors: Yonehara Yukie , Yanazume Shintaro , Kamio Masaki , Togami Shinichi , Tasaki Takashi , Douchi Tsutomu 
Published: July 2014

AbstractPseudo‐Meigs' syndrome accompanied by massive ascites in uterine leiomyoma is rare. We encountered a rare case of a 37‐year‐old, nulliparous woman with a lower abdominal tumor and severe abdominal distention due to massive ascites. Serum cancer antigen 125 and vascular endothelial growth factor levels were elevated to 1007.9 U/mL and 103 pg/mL, respectively. She was tentatively diagnosed with ovarian cancer. Emergency concentrated ascites re‐infusion therapy was performed to improve dyspnea, abdominal pain, and her preoperative respiratory condition. Concentrated ascites re‐infusion therapy eliminated dyspnea and abdominal discomfort without decreasing serum albumin levels. The patient underwent laparotomy, which revealed a fist‐sized pedunculated uterine leiomyoma arising from the right uterine fundus. Myomectomy was performed. Pseudo‐Meigs' syndrome mimics advanced ovarian cancer due to massive ascites and markedly elevated serum cancer antigen 125 and vascular endothelial growth factor levels. Concentrated ascites re‐infusion therapy was effective in improving the subjective symptoms of pseudo‐Meigs' syndrome and the patient's preoperative condition.
Clinical characteristics of amniotic fluid embolism: An experience of 29 years
Authors: Yoneyama Koichi , Sekiguchi Atsuko , Matsushima Takashi , Kawase Rieko , Nakai Akihito , Asakura Hirobumi , Takeshita Toshiyuki 
Published: July 2014

AbstractAimThe aim of this study was to elucidate the clinical characteristics and risk factors for amniotic fluid embolism (AFE).MethodsWe performed a retrospective case study analysis of patients using medical records and autopsy records. The diagnosis of AFE was based on the presence of clinical symptoms using Clark's criteria and autopsy results. We analyzed patient records from a 29‐year period in three hospitals affiliated with the Nippon Medical School in Japan.ResultsTen diagnoses of AFE were found in the records. First, we classified AFE patients into two types based on the initial presenting symptoms: post‐partum hemorrhage and cardiopulmonary collapse. Fifty percent of the patients initially presented with post‐partum hemorrhage and disseminated intravascular coagulation. Most were diagnosed with post‐partum hemorrhage or uterine atony at AFE onset. Similarly, 50% presented with cardiopulmonary arrest or pulmonary arrest as initial symptoms, and most were diagnosed with eclampsia. Second, risk factors for AFE included advanced maternal age, multiparity, increased intrauterine pressure and disruptions of the uterine vasculature. Third, the case fatality rate was 70%. Fourth, squamous cells were observed in maternal central venous blood of five patients.ConclusionAFE patients were classified into two types based on presenting signs and symptoms. Knowledge of the various initial symptoms of AFE enables a correct diagnosis.
Cerebral Infarction due to Central Vein Occlusion in a Hemodialysis Patient
Authors: Prasad Vikram , Baghai Shahine , Gandhi Dheeraj , Moeslein Fred , Jindal Gaurav 
Published: July 2014

ABSTRACTVenous congestive encephalopathy is a rare complication of central venous occlusion in hemodialysis patients with upper extremity dialysis created shunts. We describe the clinical presentation and endovascular management of an end‐stage renal disease patient with a left upper extremity arteriovenous graft who developed intracranial venous hypertension, left‐sided subdural and subarachnoid intracranial hemorrhage, and left‐sided cerebral infarcts related to a left brachiocephalic vein occlusion.
The Use of Qualitative Research Methods in Quantitative Science: A Review
Authors: Jervis M.G. , Drake M.A. 
Published: July 2014

AbstractQualitative research in the field of food science strives to understand consumer behavior and motivation. Often, these methods are used to develop a hypothesis, which can be tested through quantitative research. Traditionally, qualitative methods can provide excellent insight to consumer behavior, but the data collected can be difficult to organize and interpret. Focus groups are the most common qualitative research tool applied to understand consumer behavior and identify possible areas of focus for product development. However, ethnography and means‐end chain analysis can also be applied to understand consumer behavior and personal values. Many new qualitative techniques have been developed that attempt to mimic data normally collected in quantitative research. Grouping and projective mapping allow consumers to represent similarities and differences between products and produce maps that show how consumers perceive various attributes of these products. Each method has benefits and drawbacks, and each demands a particular data analysis methodology. Understanding these approaches is important in choosing a research method and proper interpretation of the collected data.Practical ApplicationsQualitative research is often used as a way to develop and refine hypotheses in product development. They allow for quick, inexpensive probing of consumer demands in a natural and comfortable environment. However, qualitative research can also be used as a substitute for classical quantitative profiling methods or to powerfully augment quantitative methodology.
Impacts of Hedonic and Utilitarian User Motives on the Innovativeness of User‐Developed Solutions
Authors: Stock Ruth Maria , Oliveira Pedro , von Hippel Eric 
Published: July 2014

When individual consumers develop products for their own use, they in part expect to be rewarded by the use value of what they are creating (utilitarian user motives), and in part expect to be rewarded intrinsically by such things as the fun and learning experience derived from creating it (hedonic user motives). This paper shows a first‐of‐type study to understand the relationship between individual consumers' motives to innovate and the novelty and utility of the solutions they develop. The theoretical framework integrates self‐determination theory and goal‐setting theory.The major findings of this study are that utilitarian user motives positively affect the utility of user‐developed innovations. In contrast, hedonic user motives drive solution novelty; the more an innovator is “in it for fun,” the more novel the solution developed. However, hedonic user motives also have an invertedU‐shaped relationship with solution utility. When the dominant motive for developing an innovation is the joy of the creative process rather than use value, the utility of what is developed is negatively affected. These findings are of research interest, and can be of significant practical interest to producers hoping to benefit from user‐developed innovations. For the first time, it has been possible to show that the adjustment of hedonic rewards, for example by means such as gamification, can affect the nature and utility of solutions individuals create.
Innovation Roadmapping: Building Concepts from Practitioners’ Insights
Authors: Simonse Lianne W. L. , Hultink Erik Jan , Buijs Jan A. 
Published: July 2014

Cartographic roadmaps used for navigating from A to B provide a strong metaphor for innovation roadmaps used at firms for navigating from the present to the future. Now ready to move beyond this metaphor—the pace and proliferation of knowledge on innovation roadmapping have reached a point at which it would be useful to lay out some groundwork for extended theorizing and research in this area. This paper contributes here by reporting on a qualitative inductive research based on documented practitioners’ insights.To better understand the phenomenon of innovation roadmapping (what it is and what it is not) and its impact on innovation performance, this study builds concepts in the context of strategic innovation management theory. Through a systematic analysis of the qualitative data extracted from 12 cases selected from the extant literature, this research found five concepts with common ground in these cases and built a framework in which innovation roadmapping is established by (1) a strategy of time pacing, (2) synchronizing dialogues, and (3) mapping innovation elements to a timeline. Furthermore, the systematic analysis of the documented practitioners’ insights indicates that roadmapping affects either the innovation performance of (4) competitive timing or (5) industry synergy. Overall, this leads to an initial formulation of theory with this conceptual framework and six related propositions.The key insights for innovation managers in industrial firms are that, in striving for competitive timing or industry synergy, roadmapping provides a means to achieve these objectives and, in deploying roadmapping in the organization, dialogue and pacing are critically important.