bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liver-directed gene therapy corrects cardiovascular lesions in feline mucopolysaccharidosis type I
Authors: Hinderer Christian , Bell Peter , Gurda Brittney L. , Wang Qiang , Louboutin Jean-Pierre , Zhu Yanqing , Bagel Jessica , O’Donnell Patricia , Sikora Tracey , Ruane Therese , Wang Ping , Haskins Mark E. , Wilson James M. 
Published: September 2014

Significance
Treatment of the lysosomal storage disease mucopolysaccharidosis type I (MPS I) is currently based on hematopoietic stem cell transplantation (HSCT) or weekly infusions of the deficient enzyme. To circumvent the morbidity and mortality associated with HSCT and the economic and quality of life costs of lifelong enzyme replacement therapy, we tested liver-directed gene therapy as a means of achieving endogenous enzyme expression in a feline model of MPS I. We found that hepatic gene transfer not only generated therapeutic levels of circulating enzyme, but in most cases also resulted in complete resolution of storage lesions in the cardiac valves, a tissue that is refractory to currently available therapies and responsible for much of the residual morbidity and mortality in treated patients.
Evaluation of a Sporicidal Peracetic Acid/Hydrogen Peroxide–Based Daily Disinfectant Cleaner
Authors: Deshpande Abhishek , Mana Thriveen S. C. , Cadnum Jennifer L. , Jencson Annette C. , Sitzlar Brett , Fertelli Dennis , Hurless Kelly , Kundrapu Sirisha , Sunkesula Venkata C. K. , Donskey Curtis J. 
Published: September 2014

OxyCide Daily Disinfectant Cleaner, a novel peracetic acid/hydrogen peroxide–based sporicidal disinfectant, was as effective as sodium hypochlorite for in vitro killing of Clostridium difficile spores, methicillin-resistant Staphylococcus aureus, and vancomcyin-resistant enterococci. OxyCide was minimally affected by organic load and was effective in reducing pathogen contamination in isolation roomsInfect Control Hosp Epidemiol 2014;35(11):1414–1416
Follow‐Up After pH‐Metry and pH Impedance in Pediatric Gastroesophageal Reflux Disease
Authors: van der Pol Rachel J. , van den Ouweland Marloes , Loots Clara M. , Vandenplas Yvan , Benninga Marc A. , van Wijk Michiel P. 
Published: September 2014

ABSTRACTObjectives:It is unclear how diagnostic tests for gastroesophageal reflux disease (GERD) in children relate to the course of symptoms during follow‐up.Methods:During 1 year, all children (ages 0–18 years), who underwent pH‐metry and/or pH multichannel intraluminal impedance (MII), were included after written informed consent was obtained. pH‐metry and pH‐MII test characteristics, such as reflux index (RI, % time that esophageal pH < 4), were obtained from the measurements. A questionnaire containing subcategories (medical history, gastrointestinal [GI] symptoms, extraesophageal symptoms, symptom burden, and therapeutic agents) was used; subjects were asked to fill the questionnaire at the time of inclusion and 3, 6, and 12 months afterward.Results:A total of 162 infants and 42 children were included. pH‐MII was performed in 15.4% and 57.4% of infants and children, respectively. All of the other subjects underwent pH‐metry. Median RI was 2.0% (interquartile range 3.4) in infants and 1.7% (interquartile range 2.3) in children. RI was considered positive in 6.8% and 12.8% of infants and children, respectively. In infants, RI at baseline was significantly associated with symptom burden at baseline and at 3 and 12 months of follow‐up. RI at baseline and reported GI symptoms at 3 months were also significantly associated. In infants and children using medication, symptom burden was significantly higher compared with those not using medication. This difference was found at baseline, after 3 and 12 months.Conclusions:In infants, an initial high RI is associated with persistence of GI symptoms at 3 months and a higher burden of symptoms during the course of 1 year. In children there were no such findings.
Modeling of fast pre-joining processes optimization for skin-stringer panels
Authors: Liu Gang , Tang Wei , Ke Ying-Lin , Chen Qing-Liang , Bi Yunbo 
Published: September 2014

Purpose
– The purpose of this paper is to propose a new model for optimizing pre-joining processes quickly and accurately, guiding workers to standardized operations. For the automatic riveting in panel assemblies, the traditional approach of determination of pre-joining processes entirely rests on the experience of workers, which leads to the improper number, location and sequence of pre-joining, the low quality stability and the high repair rate in most cases.

Design/methodology/approach
– The clearances computation with the complete finite element model for every process combination is time-consuming. Therefore a fast pre-joining processes optimization model (FPPOM) is proposed. This model treats both the measured initial clearances and the stiffness matrices of key points of panels as an input; considers the permissive clearances as an evaluation criterion; regards the optimal number, location and sequence as an objective; and takes the neighborhood-search-based adaptive genetic algorithm as a solution.

Findings
– A comparison between the FPPOM and complete finite element model with clearances (CFEMC) was made in practice. Further, the results indicate that running the FPPOM is time-saving by >90 per cent compared with the CFEMC.

Practical implications
– This paper provides practical insights into realizing the pre-joining processes optimization quickly.

Originality/value
– This paper is the first to propose the FPPOM, which could simplify the processes, reduce the degrees of freedom of nodes and conduct the manufacturers to standardized manipulations.
Inspector Robot – A new collaborative testing system designed for the automotive final assembly line
Authors: Müller Rainer , Vette Matthias , Scholer Matthias 
Published: September 2014

Purpose
– The paper aims to deliver an approach of how lightweight robot systems can be used to automate manual processes for higher efficiency, increased process capability and enhanced ergonomics. To show how these systems can be utilized in practice, a new collaborative testing system for an automated water leak test was designed using an image processing system utilized by the robot.

Design/methodology/approach
– The “water leak test” in an automotive final assembly line is often a significant cost factor due to its labour-intensive nature. This is particularly the case for premium car manufacturers as each vehicle is watered and manually inspected for leakage. This paper delivers an approach that optimizes the efficiency and capability of the test process by using a new automated in-line inspection system whereby thermographic images are taken by a lightweight robot system and then processed to locate the leak. Such optimization allows the collaboration of robots and manual labour which, in turn, enhances the capability of the process station.

Findings
– This paper examines the development of novel applications for lightweight robotic systems and provides a suitable process whereby the systems are optimized in technical, ergonomic and safety-related aspects.

Research limitations/implications
– A new automated testing process in combination with a processing algorithm was developed.

Practical implications
– To optimize and validate the system, it was set up in a true to reality model factory and brought to a prototypical status. Several original equipment manufacturers showed great interest in implementing the system in their assembly line.

Social implications
– The direct human–robot collaboration allows humans and robots to share the same workspace without strict separation measures which is a great advantage compared with traditional industrial robots. The workers benefit from a more ergonomic workflow and are relieved from unpleasant, repetitive and burdensome tasks.

Originality/value
– A lightweight robotic system was implemented in a continuous assembly line as a new area of application for these systems. The automated water leak test gives a practical example of how to enrich the assembly and commissioning lines, which are currently dominated by manual labour, with new technologies. This is necessary to reach a higher efficiency and process capability while maintaining a higher flexibility potential than fully automated systems.
Particle crushing simulations with improved discontinuous deformation analysis
Authors: Wang Xiao-Bo , Xu Wen-Jie , Zhang Bing-Yin , Sun Qi-Cheng 
Published: September 2014

Purpose
– Rock-fill dams are embankments of compacted free-draining granular earth containing an impervious zone. Earth utilized in such dams often contains a high percentage of large particles – hence the term rock-fill. Mass stability of these dams results from friction and particle interactions rather than through a cementing agent binding the particles together. However, high-stress conditions and prolonged exposure to the elements can severely damage rock-fill. Therefore, understanding and modeling rock-fill breakage is important for dam engineering. The purpose of this paper is to improve discontinuous deformation analysis (DDA) techniques for modeling rock-fill breakage, proving the new method using simulations of spherical particle crushing.

Design/methodology/approach
– This work models rock-fill as bonded ellipsoid particles, and develops an improved DDA method to model the breakage of particle assemblies. The paper starts by describing the principles of three-dimensional DDA for spherical particles, and then derives the submatrices for normal contact, shear contact, and frictional force. The new algorithm incorporates a bond model with a revised open-close iteration algorithm into the DDA method to simulate particle crushing. To validate the improved DDA method, calculated particle contacts and movements are validated against theoretical results. Finally, this work performs a series of point-loading experimental tests for cement ellipsoid particles of both high and low compression strengths, with the test results compared against the results from corresponding DDA simulations.

Findings
– In particle crushing tests, the force and displacement show an approximately linear relationship until the crushing point, at which point low compression ellipsoid particles split into several large pieces while the high-compression particles break into many small fragments. The DDA simulation results are in good agreement with the crushing tests, demonstrating the validity of the DDA method for solving particle crushing problems. Although the improved DDA model is applicable to rock-fill particle crushing studies, some issues remain, particularly in increasing calculation efficiency and performing large-scale computations and long real-time simulations. Future research should address these issues.

Originality/value
– A bond model with a revised open-close iteration algorithm is incorporated into the DDA method. The simulated results shed insight into rock-fill crushing mechanisms, an element of concern in engineering practices.
Topology optimization of bi-modulus structures using the concept of bone remodeling
Authors: Cai Kun , Luo Zhen , H. Qin Qing 
Published: September 2014

Purpose
– The purpose of this paper is to develop a heuristic method for topology optimization of a continuum with bi-modulus material which is frequently occurred in practical engineering.

Design/methodology/approach
– The essentials of this model are as follows: First, the original bi-modulus is replaced with two isotropic materials to simplify structural analysis. Second, the stress filed is adopted to calculate the effective strain energy densities (SED) of elements. Third, a floating reference interval of SED is defined and updated by active constraint. Fourth, the elastic modulus of an element is updated according to its principal stresses. Final, the design variables are updated by comparing the local effective SEDs and the current reference interval of SED.

Findings
– Numerical examples show that the ratio between the tension modulus and the compression modulus of the bi-modulus material in a structure has a significant effect on the final topology design, which is different from that in the same structure with isotropic material. In the optimal structure, it can be found that the material points with the higher modulus are reserved as much as possible. When the ratio is far more than unity, the material can be considered as tension-only material. If the ratio is far less than unity, the material can be considered as compression-only material. As a result, the topology optimization of continuum structures with tension-only or compression-only materials can also be solved by the proposed method.

Originality/value
– The value of this paper is twofold: the bi-modulus material layout optimization in a continuum can be solved by the method proposed in this paper, and the layout difference between the structure with bi-modulus material and the same structure but with isotropic material shows that traditional topology optimization result could not be suitable for a real bi-modulus layout design project.
Evolutionary team based on different metaheuristics for solving a real-world problem in the telecommunication domain
Authors: M. Chaves-Gonzalez Jose , A. Vega-Rodríguez Miguel 
Published: September 2014

Purpose
– The purpose of this paper is to study the use of a heterogeneous and evolutionary team approach based on different sources of knowledge to address a real-world problem within the telecommunication domain: the frequency assignment problem (FAP). Evolutionary algorithms have been proved as very suitable strategies when they are used to solve NP-hard optimization problems. However, these algorithms can find difficulties when they fall into local minima and the generation of high-quality solutions when tacking real-world instances of the problem is computationally very expensive. In this scenario, the use of a heterogeneous parallel team represents a very interesting approach.

Design/methodology/approach
– The results have been validated by using two real-world telecommunication instances which contain real information about two GSM networks. Contrary to most of related publications, this paper is focussed on aspects which are relevant for real communication networks. Moreover, due to the stochastic nature of metaheuristics, the results are validated through a formal statistical analysis. This analysis is divided in two stages: first, a complete statistical study, and after that, a full comparative study against results previously published.

Findings
– Comparative study shows that a heterogeneous evolutionary proposal obtains better results than proposals which are based on a unique source of knowledge. In fact, final results provided in the work surpass the results of other relevant studies previously published in the literature.

Originality/value
– The paper provides a complete study of the contribution provided by the different metaheuristics included in the team and the impact of using different sources of evolutionary knowledge when the system is applied to solve a real-world FAP problem. The conclusions obtained in this study represent an original contribution never reached before for FAP.
The role of budget speech: a Malaysian Government study
Authors: Ferry Laurence , Zakaria Zamzulaila , Eckersley Peter 
Published: September 2014

Purpose
– The purpose of this paper is to study the role of budget speech in the Malaysian Government as a “hybrid” for governing both the economy and social cohesion.

Design/methodology/approach
– Through archival research, a governmentality framework and the concept of hybrids (Miller et al., 2008) are employed to explore the role of budget speech in articulating ways in which the government managed the economic and social agenda.

Findings
– Previous governmentality studies have primarily been conducted on economic performance in western liberal democracies. Such research has illustrated the framework, measures undertaken by the government and choices of the governable person in actions for economic life. This paper applies these studies to a South East Asian context and finds that budget speeches between 2007 and 2011 are hybrids, in that they set out ways of achieving the two key priorities of post-independence Malaysia – the need to promote economic development whilst also fostering social harmony. Most notably, it finds that economic development was the dominant priority in those budget speeches held prior to the global financial crisis and 2008 general election, whereas social cohesion assumed this position from 2009 onwards.

Originality/value
– The findings have both practical and social implications for Malaysia, but also other jurisdictions that are using budget speeches to try to promote economic reforms and foster social cohesion.
Supplier development and public procurement: allies, coaches and bedfellows
Authors: Mark McKevitt David , Davis Paul 
Published: September 2014

Purpose– Using the lens of mentoring theory the authors test the extent to which public buyers informally support suppliers and the influence of organisational context on mentoring support. The paper aims to discuss these issues.Design/methodology/approach– Principal component analysis was used to analyse questionnaire responses from over 300 public buyers in Ireland. Cluster analysis produced three mentor profiles.Findings– The findings show a positive relationship between organisations that take a strategic approach to suppliers and buyers who offer career and psychosocial support to suppliers. However, those organisations that lack a strategic perspective of suppliers saw buyers offer political support and coaching.Research limitations/implications– The implications are that coaching and political support may compensate for deficits in organisational support for suppliers generally. The findings contribute to a growing literature on informal interaction opportunities in public procurement.Originality/value– To date research of supplier development is limited to formal developmental activities and in the context of private sector buyer-supplier relationships.
Multi-type childhood maltreatment: associations with health risk behaviours and mental health problems in adolescence
Authors: Mangion Mariella , C. Buttigieg Sandra 
Published: September 2014

Purpose– The purpose of this paper is to determine whether multi-type child maltreatment is associated with health-risk behaviours and mental ill-health in adolescence.Design/methodology/approach– In total, 406 15-16-year-old students from Maltese schools answered the “Child maltreatment physical and mental health” questionnaire (Nguyenet al., 2010). This assessed demographics, health risk behaviour, mental health and child maltreatment.Findings– Of the four categories of maltreatment measured (physical, sexual, emotional and neglect), 27.4 per cent of the young people experienced one type, 16.6 per cent two types, 11.1 per cent three and 6.5 per cent four. For health-risk behaviours, there were positive relationships between multi-type maltreatment and school fights (r=0.27,p<0.01), breaking school rules (r=0.19,p<0.01), illicit drug use (r=0.14,p<0.05) and alcohol use (r=0.10,p<0.05). As regards mental health, multi-type maltreatment was positively associated with depression (r=0.38,p<0.01) and anxiety (r=0.23,p<0.01), and negatively associated with self-esteem (r=−0.26,p<0.01).Practical implications– Early recognition of multi-type maltreatment and its consequences enables providers of children's services to offer the required diverse range of services. Additionally, policy makers should ensure the adoption of multi-sectoral and collaborative inter-agency approaches so as to effectively and holistically manage child maltreatment, not only during the acute childhood phase but also during adolescence and adulthood, when consequences are expected to emerge.Originality/value– This study raises awareness about the prevalence of multi-type child maltreatment in Malta. It also highlights the negative association between cumulative exposure to multi-type child maltreatment and mental health outcomes and risky behaviours.
Production efficiency of Chinese banks: a revisit
Authors: Tina Zhang Xiaotian , Wang Yong 
Published: September 2014

Purpose
– The last decade witnessed the reform of China's financial sector, during which Chinese commercial banks’ ownership and operation had been significantly changed in order to improve efficiency. The purpose of this paper is to investigates whether these banks have improved their productivity efficiency during their rapid expansion and growth in the post reform era from 2004 to 2011.

Design/methodology/approach
– Data envelopment analysis is used to investigate the production efficiency of Chinese commercial banks during 2004-2011. First, the technical efficiency (TE) score is constructed to evaluate bank productivity. The TE score is disintegrated into pure technical efficiency (PTE) and scale efficiency (SE) to examine the effects of technical factors and scale economies. Second, the Malmquist index is constructed to explore the year-by-year productivity. Lastly, regression analysis examines how bank characteristics and ownership structure affect productivity efficiency.

Findings
– The Big Four banks are less efficient than other commercial banks, and public banks are less efficient than private banks. The low efficiency is primarily due to scale inefficiency, rather than PTE. In addition, ownership structure impacts production efficiency. Specifically, foreign ownership is related to high efficiency while state ownership is associated with lower productivity.

Research limitations/implications
– There were small observations of public banks in China. Thus, a more comprehensive test is impractical to explore whether or not annual changes in ownership structure improve their production efficiency. With more date, such a test will reveal further information about the relationship between ownership and productivity.

Originality/value
– The authors are the first to assess the production efficiency of Chinese commercial banks after the recent financial reform during which Chinese commercial banks had undergone significant structural changes. The lower overall productivity of Big Four and public banks is a result of scale inefficiency, although these banks are better than their peers with respect to input-output transformation.