bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitators and Barriers to Implementation of Early Intensive Manual Therapies for Young Children with Cerebral Palsy Across Canada
Authors: Vurrabindi Divya , Hilderley Alicia J , Kirton Adam , Andersen John , Cassidy Christine , Kingsnorth Shauna , Munce Sarah , Agnew Brenda , Cambridge Liz , Herrero Mia , Leverington Eleanor , McCoy Susan , Micek Victoria , Connor Keith O , Grady Kathleen O’ , Reist-Asencio Sandra , Tao Chelsea , Tao Stephen , Fehlings Darcy 
Published: August 2024

Abstract

Background: Cerebral Palsy (CP) is the most common childhood-onset motor disability. Play-based early intensive manual therapies (EIMT) is an evidence-based practice to improve long-term hand function particularly for children with asymmetric hand use due to CP. For children under two years old, this therapy is often delivered by caregivers who are coached by occupational therapists (OTs). However, why only a few Canadian sites implement this therapy is unclear. There is a need to identify strategies to support implementation of EIMT. The primary objective of this study was to identify the facilitators and barriers to EIMT implementation from the perspectives of (1) caregivers of children with CP, (2) OTs and (3) healthcare administrators for paediatric therapy programs.
Methods: The Consolidated Framework for Implementation Research (CFIR) was used to guide development of an online 5-point Likert scale survey to identify facilitators (scores of 4 and 5) and barriers (scores of 1 and 2) to implementation of EIMT. Three survey versions were co-designed with knowledge user partners for distribution to caregivers, OTs, and healthcare administrators across Canada. The five most frequently endorsed facilitators and barriers were identified for each respondent group.
Results: Fifteen caregivers, 54 OTs, and 11 healthcare administrators from ten Canadian provinces and one territory participated in the survey. The majority of the identified facilitators and barriers were within the ‘Inner Setting’ CFIR domain, with ‘Structural Characteristics’ emerging as the most reported CFIR construct. Based on the categorization of the most frequently endorsed facilitators and barriers within the CFIR domains, the key facilitators to EIMT implementation included the characteristics of the intervention and establishing positive workplace relationships and culture. The key barriers included having workplace restrictions on EIMT delivery models and external influences (e.g., funding) on EIMT uptake.
Conclusions: We identified key facilitators and barriers to implementing EIMT from a multi-level Canadian context. These findings will inform the next steps of designing evidence-informed and theory-driven implementation strategies to support increased delivery of EIMT for children under two years old with asymmetric hand use due to CP across Canada.
Interventions That Improve the Uptake of Antenatal Care Services in	Sub-saharan Africa: a Systematic Review and Meta-analysis
Authors: Galadanci Hadiza , Maiyaki Baba Musa , Omeje Ifesinachi Joy , Farouk Zubaida , Yakasai Ahmed MaiFada , Owolabi Lukman Femi , Odjesa Emomine , Onoh Vivian , Okonofua Friday , Ogaji Daprim , Ndiaye Ousmane , Sowemimo Abimbola , Muula Adamson 
Published: August 2024

Abstract

Introduction: Despite 70% of global maternal deaths occurring in sub-Saharan Africa (SSA), antenatal care (ANC) still remains underutilized with diverse, inconsistent impact from interventions. This systematic review identifies the most effective interventions to improve ANC uptake in the region, aiming to inform policy decisions and ultimately reduce maternal and perinatal mortality.
Methods: A systematic review of studies published between 2000 and 2022 was conducted to identify effective interventions that improve ANC uptake in SSA. Studies were screened using Rayyan softwareâ, and data was extracted by two reviewers. Interventions included ICT interventions, financial incentives, mobile clinics, and pharmacological interventions. Studies were included if they were conducted in SSA, and if they reported on maternal-fetal outcomes. Data was synthesized using a narrative and graphic approach and meta-analysis was conducted using the empirical Bayes method. Publication bias was assessed using Egger's and Begg's tests and addressed using the Trim and Fill method.
Results: In an analysis of 17 studies, which all either had the cluster-randomized controlled trial or randomized controlled trial study design, we investigated the effectiveness of diverse interventions in increasing ANC attendance. Our findings revealed an overall increase in ANC utilization across all interventions (OR=3.94, RR=1.16). Sub-group analysis further identified studies jointly reported from Kenya and Nigeria as demonstrating the highest impact. However, a crucial caveat emerged with the detection of publication bias, prompting cautious interpretation, and emphasizing the need for further research.
Conclusion: Our analysis offers valuable insights for policymakers aiming to optimize interventions and maximize ANC uptake, potentially paving the way for improved maternal and perinatal outcomes in SSA.
Circulating Hsp70 - a tumor biomarker for lymph node metastases and early relapse in thoracic cancer
Authors: Lobinger Dominik , Taylor Nicholas , Messner Verena , Seier Sophie , Bodner Johannes , Roberts Erika , Dezfouli Ali Bashiri , Pockley Alan Graham , Safi Seyer , Multhoff Gabriele 
Published: August 2024

Abstract

Background: Heat shock protein 70 (Hsp70) which is frequently overexpressed in many different cancer types is also present on the plasma membrane of tumor but not normal cells. The intensity of membrane-expressed Hsp70 (mHsp70) is associated with disease progression and treatment resistance. It has also been shown that Hsp70 can be actively released into the circulation by mHsp70 positive, viable tumor cells in the form of extracellular lipid microvesicles expressing mHsp70, the levels of which might therefore act as a potential biomarker for tumor aggressiveness in lung malignancies.
Methods: Extracellular Hsp70 (eHsp70) was measured in the plasma of patients with non-small cell lung cancer (n=178, NSCLC) and lung metastases of extrathoracic tumors (n=35) prior to surgery using the Hsp70-exo ELISA which detects microvesicle-associated Hsp70 and the patient`s immunophenotype was determined by flow cytometric analysis of the corresponding peripheral blood lymphocytes.
Results: eHsp70 values were significantly higher in patients with NSCLC than in healthy individuals, with no differences between adeno and squamous cell carcinomas. Levels of circulating Hsp70 gradually increased from early stage to metastatic disease, and patients with lymph node metastases in surgically treatable NSCLC had significantly higher eHsp70 levels than nodal negative patients. In all tumor stages, total lymphocyte counts were significantly reduced and Treg counts were increased compared to healthy controls. Lower CD4+ T helper cell and higher CD3-/CD56+/CD94+/CD69+/NKp30+/NKp46+ NK cell ratios were only found in patients with thoracic metastases of other primary tumors. An early relapse after complete resection with curative intent correlated with significantly elevated eHsp70 levels, which were measured prior to surgery, in all lung cancer patients.
Conclusions: In summary, we propose circulating eHsp70 levels as a predictive biomarker for the presence of lymph node metastases and early therapy failure in patients with thoracic malignancies.
ResSAT: Enhancing Spatial Transcriptomics Prediction from H&amp;E- Stained Histology Images with Interactive Spot Transformer
Authors: Liu Anqi , Zhao Yue , Shen Hui , Ding Zhengming , Deng Hong-Wen 
Published: August 2024

Abstract

Spatial transcriptomics (ST) revolutionizes RNA quantification with high spatial resolution. Hematoxylin and eosin (H&E) images, the gold standard in medical diagnosis, offer insights into tissue structure, correlating with gene expression patterns. Current methods for predicting spatial gene expression from H&E images often overlook spatial relationships. We introduce ResSAT (Residual networks - Self-Attention Transformer), a framework generating spatially resolved gene expression profiles from H&E images by capturing tissue structures and using a self-attention transformer to enhance prediction. Benchmarking on 10x Visium datasets, ResSAT significantly outperformed existing methods, promising reduced ST profiling costs and rapid acquisition of numerous profiles.
Integration of Modbus Ethernet Communication for Real-Time Electrical Power Consumption, Temperature, and Humidity Monitoring System
Authors: Le Long Ho , Nguyen Duc Toan , Bui Hong Phong , Nguyen Chi Cuong , Ngo Thanh Quyen 
Published: August 2024

Abstract

Effective management of electrical energy requires monitoring, controlling, and storing parameters gathered from power measurement devices including voltage, current, and power factor. This assessment of the quality of electrical energy is essential for management organizations, power companies, and individual consumers to develop efficient electricity usage plans. In this paper, we propose a hardware implementation for data collection and online communication software integrated with a system for collecting data on consumption of electrical energy. The EM115-Mod CT multifunction industrial meters by the FINECO, the KLEA 220P three-phase multifunction meter by the KLEMSAN, and the ME96SS–ver.B by MITSUBISHI are firstly utilized. Finally, the collected data of voltage, current, electrical consumption, temperature, and humidity can be stored on the SD card and transmitted to the cloud for real-time monitoring on mobile devices facilitated by the ESP-WROOM-32 microcontroller from the Espressif system. The obtained results showed that the temperature and the humidity changed gradually with time and remained within the standard range of temperature and relative humidity.
The Effects of Nutrition on Depression in Older Adults Living in Nursing Homes: A Dilemma or a Vicious Circle?
Authors: POYRAZ Turan , Cilengiroglu Ozgul Vupa , Oy Nil Bruk 
Published: August 2024

Abstract

Background This study intends to evaluate the effects of nutritional status on depression and other geriatric syndromes in older adults living in nursing homes.
Methods In this cross-sectional study, the GDS-30 and Mini Nutritional Assessment (MNA) were used to assess depression and malnutrition, respectively. Cognitive functions were assessed by the Mini-Mental State Examination (MMSE). Multiple linear regression analysis was conducted to determine the independent associations among the MNA score, GDS score and MMSE score. Data collection was performed prospectively through random, face-to-face interviews in nursing homes.
Results A total of 126 patients who met the inclusion criteria were included in the study. The average age of the participants in the study group was 77.05±5.68 (median=76.0) years. According to the Kruskal‒Wallis test, a statistically significant difference was found between the median GDS score and the median age in the MNA score categories (p<0.05). The risk of malnutrition was approximately 10 times greater in patients with dementia (OR = 10.22).
Conclusions The results indicate a strong association between depression and malnutrition in the elderly population. The relationship between malnutrition, depression and cognitive impairment in elderly individuals with chronic neurological diseases living in nursing homes coincides with the data obtained regarding the disruption of the gut-brain-axis (GBA) through neuroimmunoendocrine pathways and the inability to maintain homeostatic balance in the central nervous system (CNS).
Clinical features of cytomegalovirus retinitis, A retrospective analysis of 90 patients
Authors: Zhang Yan , Yu lei , Li Na , Zhang Ge 
Published: August 2024

Abstract

Background To analyze the clinical features of patients with cytomegalovirus retinitis and provide evidence for a better understanding of the disease.Methods A retrospective analysis was conducted on the clinical manifestations of 90 patients with cytomegalovirus retinitis. The analysis included general data, visual acuity, intraocular pressure, anterior segment examination, vitreous body examination, and color fundus photography.Results The patients' ages ranged from 1 to 64 years, with 59 males and 31 females. Among the 90 patients, 18 had acquired immune deficiency syndrome (AIDS) as a secondary condition, 70 had various types of hematological diseases following bone marrow transplantation, 1 had a history of thymus extraction, and 1 had congenital autoimmune hemolytic anemia. Of the affected eyes, 35 cases were monocular and 55 were binocular. Anterior chamber inflammation was observed in 67 eyes out of 145 affected eyes, while 40 eyes showed significant vitreous inflammation. Some cases exhibited typical "cheese and ketchup" changes during fundus examination, with various fundus manifestations observed. Based on the extent and location of the lesions, they were classified into diffuse, hemilateral, and focal types.Conclusion Cytomegalovirus retinitis is more prevalent among immunodeficient individuals rather than those with normal immune systems. Regular eye examinations are recommended for patients of AIDS diagnosis and bone marrow transplantation. Understanding the clinical characteristics of the disease can aid in early diagnosis and treatment.
Body image alterations in eating disorders patients: a systematic review of neuroimaging studies
Authors: de Carvalho Marcela Nunes Paulino , Dias Manuela Capezzuto Fernandes , Nogueira Thiago De Raphael , Cordás Táki Athanássios , Teixeira Paula Costa 
Published: August 2024

Abstract

Body image distortion (BID) is a core diagnostic criteria for anorexia nervosa (AN), bulimia nervosa (BN) and purging disorder. Binge eating disorder (BED) may also presents this symptom, however, it isn't yet a criteria recognized by DSM-V. It's speculated whether there are neurobiological factors that may collaborate with EDs vulnerability and maintenance. We aimed to discuss, through a systematic review, BID's neurobiology through studies that used neuroimaging tools in patients with AN, BN, purging disorder and BED. Review was developed using guideline PRISMA recommendation, following 27-step checklist and four-phase flowchart. In May and August 2021, following databases were consulted: Lilacs, Scielo, Pepsic, APA/Psycnet, Pubmed, Scopus, Bireme, Cochrane. 1,532 articles were found and 2.02% were included in this research. Body image distortion seems associated with paralimbic structures (cingulate cortex and insula); default-mode network; parietal, temporal and occipital structures. Paralimbic structures and default-mode network were associated with a change regarding the subjective self (material self) and ego. It's also possible to infer that these patients present a perceptual error of judgment and excess of self reference and self-investment in themselves, whose attempt would be to resolve the perceptual error, reinforcing ED dysfunctional behaviors.
Profiling Expression of Brac2 Gene in Cases of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders-a Pilot Study.
Authors: - ARUSHI , jain Hrithik 
Published: August 2024

Abstract

Oral Potentially Malignant Disorders (OPMD) are heterogenous mucosal lesions of oral cavity, which when compared to their normal and other diseased counterparts, are prone to have increased probability/ risk of transformation to malignancy i.e. Oral Squamous Cell Carcinoma (OSCC). Once diagnosed, they pose challenge because of the intrinsic potential to develop into OSCC. So, for a proper follow-up and continued monitoring of such lesions, a common marker which could be applied on the tissues presents itself in results microscopically in such a way that is not only precise and accurate for the prediction of transforming rate, but also draws instant attention to the lesion to halt the progression and prevent further morbidity and financial constraints. Carcinogenesis is a multi-step, multi-gene, and multi-stage complex process involving the oncogene activation and inactivation of tumour suppressor genes. Thereby, not only knowing and the genes is important for diagnosis, but also the molecular pathogenesis and the protein formation underlying disease progression is important, which would help not only in knowing the disease process, but also to identify and prevent the disease beforehand to improve patient’s life outcomes. Thereby, this study identified the expression of tumour suppression gene (TSG), BRAC2 gene, in cases of both OSCC and OPMDs. The results showed that with increased grade and severity of the lesion, the expression of this gene was not seen in either category of the lesions. Thereby, we conclude that a large no of sample size study would be the need to confirm the findings.
The association between neutrophil to lymphocyte ratio and covert brain infarction after carotid endarterectomy: a single center retrospective study
Authors: Han Yunfeng , Lai Xuan , Zhang Hua , Yang Jun , Wang Tao 
Published: August 2024

Abstract

Background
Neutrophil to lymphocyte ratio (NLR) is a biomarker which is related with inflammation and atherosclerosis. Higher NLR is associated with vulnerability of carotid atherosclerotic plaques. Covert brain infarction (CBI) following carotid endarterectomy (CEA) indicates poor prognosis in cognization. In this study, we aimed to investigate the relationship between NLR and CBI in patients who accepted CEA.
Methods
In this observational and retrospective cohort study, 333 patients who underwent CEA due to severe carotid artery stenosis were enrolled. NLR was acquired from routine blood tests upon admission. Postoperative CBI was detected on magnetic resonance imaging. Logistic regression analysis was used to examine the association between NLR and CBI.
Results
Patients with CBI had higher NLR (CBI patients: 2.45[1.76–3.58] vs non-CBI patients: 2.31[1.82–2.88]; P = 0.05). NLR is a strong independent factor predicting the risk of CBI following CEA (odds ratio [OR], 1.740; 95% confidence interval [CI]: 1.325–2.286; P < 0.001). Furthermore, the predictive risk value by NLR is not affected by other related factors.
Conclusions
NLR is associated with the risk of CBI in patients underwent CEA. NLR is a convenient and low-cost biomarker that can be used for risk stratification management of perioperative carotid stenosis patients.
Causal Relationship between Peripheral Immune Cell Counts and Inflammatory Bowel Diseases: A Bi-directional Two-sample Mendelian Randomization Study
Authors: Huang Xueping , Wang Hao , Li Xingang , Shi Haiyun 
Published: August 2024

Abstract

Background Observational studies have described an association between peripheral immune cell counts and inflammatory bowel diseases (IBD), but the exact causal relationship between them remains unclear. Therefore, a bi-directional two-sample Mendelian Randomization (MR) study was conducted to explore this potential causality.Methods GWAS summary data for peripheral immune cell counts were obtained from Blood Cell Consortium with 563,085 subjects of European ancestry, and data for IBD, Cronh’s disease (CD), and ulcerative colitis (UC) were obtained from five independent cohorts with 368,819 subjects of European ancestry. Single-variable Mendelian randomization (SVMR) was performed and followed by multivariable Mendelian randomization (MVMR) to assess the causal effects of peripheral immune cell counts on IBD risk.Results SVMR estimates showed that genetically predicted higher leukocytes [odds ratio (OR): 1.225, 95% confidence interval (CI): 1.027–1.452, P = 0.027] and neutrophils (OR: 1.281, 95% CI: 1.044–1.572, P = 0.018) increased risk of CD, and higher eosinophils increased risk of UC (OR: 1.288, 95% CI: 1.067–1.412, P = 0.005). In MVMR, the effects of neutrophils (OR: 1.653, 95% CI: 1.139–2.405, P = 0.010) and eosinophils (OR: 1.303, 95% CI: 1.016–1.668, P = 0.040) were still significant. Reverse MR analysis showed higher basophils (OR: 1.013, 95% CI: 1.001–1.014, P = 0.049) and eosinophils (OR: 1.012, 95% CI: 1.004–1.023, P = 0.027), and lower lymphocytes (OR: 0.993, 95% CI: 0.984-0,997, P = 0.015) in patients with IBD, with specific increases in neutrophils for CD (OR: 1.011, 95% CI: 1.005–1.014, P = 0.044) and basophils for UC (OR: 1.012, 95% CI: 1.004–1.023, P = 0.013).Conclusions These findings imply that increased peripheral neutrophil and eosinophil counts are potential causal risk factors for IBD, and IBD could affect the level of basophil, neutrophil, and lymphocyte count in turn. Our results may offer potential insights for the development of biomarkers and targeted treatment strategies for IBD.
Lifestyles and socioeconomic status associated with sleep duration and quality of Gangwon Province residents
Authors: Yim Soo Hwan , Kim Si-Yeon , Park Woong-Sub 
Published: August 2024

Abstract

Background
Sleep health-related indicators are deeply associated with social status and income level. Differences in sleep duration and quality in the USA varied based on race, ethnicity, and socioeconomic status. National studies or studies focusing on the residents of metropolitan areas may only reflect a part of Korea.
Objective
We aimed to explore the relationship between sleep health and lifestyles, as well as socioeconomic status in Gangwon Province.
Methods
The present study utilized raw data from the 2018 Korean Community Health Survey (KCHS) conducted by the Korean Centers for Disease Control and Prevention. The KCHS is a cross-sectional survey with a study population drawn from multistage, stratified area probability samples of civilian, non-institutionalized Korean households in Gangwon Province. Using data from the KCHS of 1,296,218 Korean individuals residing in Gangwon Province (648,888 men and 647,330 women), we conducted cross-sectional analysis with sex subgroup analysis. Sleep duration was classified into three groups—short (< 7 hours), medium (7–9 hours), and long (> 9 hours). The Pittsburgh Sleep Quality Index (PSQI) score was used to classify sleep quality into two groups—poor (PSQI > 5) and good sleep (PSQI ≤ 5).
Results
Poor sleep quality was associated with lower income, low education level, irregular breakfast patterns, old age (> 50), higher subjective stress, diabetes, and depression.
Conclusion
Sleep health is closely related to the socioeconomic status among Gangwon Province residents.
Enhancing Trade Prediction of Environmental Goods: Integrating Traditional Gravity Models with Machine Learning
Authors: Park Wan , Kwon Oh-Jin , Chun Hong-Woo , Kwon Lee-Nam 
Published: August 2024

Abstract

This research investigates the efficacy of integrating traditional gravity models with deep learning methodologies to predict trade flows of environmental goods. By merging machine learning with the gravity model, this study aims to enhance the accuracy of import and export predictions across various sectors. Analysing a comprehensive dataset spanning a 20-year period and employing advanced machine learning techniques, the paper identifies key variables (GDP, distance, common language, landlocked, etc.) influencing trade predictions and assesses their contributions within the models. The findings reveal that machine learning-enhanced models significantly improve predictive accuracy over the standalone use of traditional gravity models. This highlights the potential of combining advanced computational techniques with conventional economic models to better understand and forecast environmental goods trade dynamics. This study not only contributes to theoretical advancements in trade prediction but also offers practical insights for policymakers aiming to facilitate trade in environmental goods, ultimately supporting global sustainability efforts.