bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coagulation factor XIII deficiency
Authors: Ivaskevicius V. , Thomas A. , Oldenburg J. , Biswas A. 
Published: February 2014

SummaryThe plasma circulating zymogenic coagulation factor XIII (FXIII) is a protransglutaminase, which upon activation by thrombin and calcium cross-links preformed fibrin clots/fibrinolytic inhibitors making them mechanically stable and less susceptible to fibrinolysis. The zymogenic plasma FXIII molecule is a heterotetramer composed of two catalytic FXIII-A and two protective FXIII-B subunits. Factor XIII deficiency resulting from inherited or acquired causes can result in pathological bleeding episodes. A diverse spectrum of mutations have been reported in the F13A1 and F13B genes which cause inherited severe FXIII deficiency. The inherited severe FXIII deficiency, which is a rare coagulation disorder with a prevalence of 1 in 4 million has been the prime focus of clinical and genetic investigations owing to the severity of the bleeding phenotype associated with it. Recently however, with a growing understanding into the pleiotropic roles of FXIII, the fairly frequent milder form of FXIII deficiency caused by heterozygous mutations has become one of the subjects of investigative research. The acquired form of FXIII deficiency is usually caused by generation of autoantibodies or hyperconsumption in other disease states such as disseminated intravascular coagulation. Here, we update the knowledge about the pathophysiology of factor XIII deficiency and its therapeutic options.
Triple negative breast cancer: 5-year results of combined treatment
Authors: Ostapenko Valerijus , Pipirienė Želvienė Teresė , Smailytė Giedrė , Ostapenko Andrej , Meškauskas Raimundas 
Published: February 2014

Background. Breast cancer is the most common female cancer worldwide. It is a heterogeneous disease with regard to biological behaviour, responses to treatment and prognosis. The term “triple negative breast cancer” (TNBC), namely, refers to the immunohistochemical classification of breast tumours lacking ER, PgR, and HER2 protein expression. TNBC does not respond to endocrine therapy and chemotherapy remains the main systemic therapeutic option in the adjuvant and metastatic setting of TNBC.
The aim of this study was a retrospective analysis of the results of combined treatment for TNBC.
Patient and methods. In our retrospective analysis, we analized 431 patients with TNBC treated with combination therapy from March 2005 until December 2009 at the Institute of Oncology, Vilnius University. 52.20% of the whole group of patients were women older than 50 years. Stage I was diagnosed in 23.9%, stage II in 49.65%, stage III in 22.74%, stage IV in 3.71% of cases. According to pathological types of the tumour ductal invasive carcinoma was diagnosed in 376 patients (87.24%) and tumour grade G3 was determined in 330 patients (76.57%). All 431 patients underwent surgical treatment, 239 patients had chemotherapy (55.45%). The disease-free survival and overall survival were estimated by the Kaplan-Meier method. The Log-rank test was used for survival comparison between the groups. P
Five-year survival after sigmoid resection and low vascular ligation versus left hemicolectomy and high ligation for stage I–III sigmoid carcinoma: a retrospective study
Authors: Vitkauskas Vytautas , Samalavičius Narimantas Evaldas , Vitkauskienė Marija 
Published: February 2014

Background. There is still a discussion whether or not high ligation of the inferior mesenteric artery and vein during surgery for sigmoid cancer has survival benefit compared to low ligation. Both operations are used today. The aim of our study was to evaluate retrospectively 5-year survival after low ligation in comparison with high ligation for stage I–III sigmoid cancer.
Materials and methods. We reviewed 127 patients who were operated on for stage I–III sigmoid cancer during the period of 5 years (1 January 2003 – 31 December 2007) at the Oncology Institute of Vilnius University. Left hemicolectomy was performed in 20 cases (Group 1), whereas sigmoid resection was performed in 107 cases (Group 2). In Group 1 there were 10 men and 10 women, mean age was 66.4 (std. dev. 7.816, range 50–78). In Group 2 there were 46 men and 61 women, mean age was 66.71 (std. dev. 9.964, range 40–82).
Results. Mean hospital stay was 15.8 days (std. dev. 4.895, min. 10, max. 30) in Group 1 and 17.47 days (std. dev. 4.995, min. 7, max. 37) in Group 2 (p > 0.005). There were 2 postoperative complications in Group 1 (10%) and 27 in Group 2 (25.2%) (p > 0.005). 5-year survival in Group 1 was 70%, in Group 2 it was 72.9% (p > 0.005).
Conclusions. In our study there was no significant difference in oper­ating time and other variables between the groups, but higher postoperative complication rate and a longer hospital stay was observed after sigmoid resection with low ligation in comparison with left hemicolectomy with high ligation. However, five-year survival rate was not different between the groups. In conclusion, our findings conclude that both techniques give adequate oncological results in cases of sigmoid cancer.
Firm Earnings Persistence over the Business Cycle: Evidence from Listed Companies in China1
Authors: Li Qingyuan , Wang Hongjian , Rong Xin 
Published: February 2014

Abstract
On the basis of the analytical framework of Tomy (2012) and utilising the 2008 financial crisis as a natural experiment, this paper empirically examines the relationship between earnings persistence and the business cycle. First, compared with earnings persistence during expansion periods, earnings persistence significantly declines when the economic climate worsens. Moreover, the cash component of earnings is more sensitive to the business cycle than the accrual component. Second, compared with the earnings persistence of companies audited by non-Big-Four firms, the earnings persistence of companies audited by the Big Four is more susceptible to the business cycle. Third, compared with the earnings persistence of companies with a highly concentrated shareholding, the earnings persistence of companies with a low degree of ownership concentration is more susceptible to the business cycle. The results demonstrate that economic cyclical fluctuations, as the basic economic operation in the macroeconomy, can exert a direct influence on the earnings persistence of enterprises (micro economy) by affecting firm fundamentals as well as earnings management. In addition, the effect of firm fundamentals on earnings persistence is pro-cyclical, while the effect of earnings management on earnings persistence is counter-cyclical. Therefore, the higher the quality of accounting information and corporate governance, the more susceptible earnings persistence is to the business cycle. Our study contributes evidence that will help to determine how, and in what direction, earnings management affects earnings persistence over the business cycle and provides empirical evidence to enhance our understanding of the mechanism through which the business cycle can influence earnings persistence.
Socio‐hydrology: Use‐inspired water sustainability science for the Anthropocene
Authors: Sivapalan M. , Konar M. , Srinivasan V. , Chhatre A. , Wutich A. , Scott C. A. , Wescoat J. L. , Rodríguez‐Iturbe I. 
Published: February 2014

AbstractWater is at the core of the most difficult sustainability challenges facing humans in the modern era, involving feedbacks across multiple scales, sectors, and agents. We suggest that a transformative new discipline is necessary to address many and varied water‐related challenges in the Anthropocene. Specifically, we propose socio‐hydrology as a use‐inspired scientific discipline to focus on understanding, interpretation, and scenario development of the flows and stocks in the human‐modified water cycle across time and space scales. A key aspect of socio‐hydrology is explicit inclusion of two‐way feedbacks between human and water systems, which differentiates socio‐hydrology from other inter‐disciplinary disciplines dealing with water. We illustrate the potential of socio‐hydrology through three examples of water sustainability problems, defined as paradoxes, which can only be fully resolved within a new socio‐hydrologic framework that encompasses such two‐way coupling between human and water systems.
Earth's future in the Anthropocene: Technological interventions between piecemeal and utopian social engineering
Authors: Schäfer Stefan , Stelzer Harald , Maas Achim , Lawrence Mark G. 
Published: February 2014

AbstractAn extensive discussion in the academic and policy communities is developing around the possibility of climate engineering through stratospheric aerosol injection (SAI). In this contribution, we develop a perspective on this issue in the context of the wider setting of societal development in the Anthropocene. We draw on Karl Popper's concepts of piecemeal and utopian social engineering to examine how different visions of societal development relate to SAI. Based on this reflection, we argue that the debate on SAI is fueled not only by the inequitable distribution of its effects and potential atmospheric and climatic side effects, as disconcerting as some of these effects and side effects may be, but also, and perhaps primarily, by its apparent privileging of the status quo and incremental change over a more immediate and radical change in societal organization. Although differing ideological orientations might thus help explain the intensity of parts of the debate, the understanding from which they follow, in which societal development is deduced from postulated technological characteristics and assumptions about a technology's use, hides from view a more subtle understanding of the relationship between technology and politics.
Impact of wind waves on the air‐sea fluxes: A coupled model
Authors: Kudryavtsev V. , Chapron B. , Makin V. 
Published: February 2014

AbstractA revised wind‐over‐wave‐coupling model is developed to provide a consistent description of the sea surface drag and heat/moister transfer coefficients, and associated wind velocity and temperature profiles. The spectral distribution of short wind waves in the decimeter to a few millimeters range of wavelengths is introduced based on the wave action balance equation constrained using the Yurovskaya et al. (2013) optical field wave measurements. The model is capable to reproduce fundamental statistical properties of the sea surface, such as the mean square slope and the spectral distribution of breaking crests length. The surface stress accounts for the effect of airflow separation due to wave breaking, which enables a better fit of simulated form drag to observations. The wave breaking controls the overall energy losses for the gravity waves, but also the generation of shorter waves including the parasitic capillaries, thus enhancing the form drag. Breaking wave contribution to the form drag increases rapidly at winds above 15 m/s where it exceeds the nonbreaking wave contribution. The overall impact of wind waves (breaking and nonbreaking) leads to a sheltering of the near‐surface layer where the turbulent mixing is suppressed. Accordingly, the air temperature gradient in this sheltered layer increases to maintain the heat flux constant. The resulting deformation of the air temperature profile tends to lower the roughness scale for temperature compared to its value over the smooth surface.
The Chan–Lam Reaction of Chalcogen Elements Leading to Aryl Chalcogenides
Authors: Yu Jin‐Tao , Guo Huan , Yi Yuanqiuqiang , Fei Haiyang , Jiang Yan 
Published: February 2014

AbstractA copper‐catalyzed chalcogenation of arylboronic acids with elemental sulfur or selenium is established, which provides diaryl disulfides or diaryl monoselenides in moderate to good yields with excellent selectivities, respectively. Moreover, after sequential reduction and coupling with aryl/alkyl iodides in one pot, unsymmetrical monosulfides were obtained in good yields.magnified image
Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: Phase 1 trial outcomes
Authors: Feldman Eva L. , Boulis Nicholas M. , Hur Junguk , Johe Karl , Rutkove Seward B. , Federici Thais , Polak Meraida , Bordeau Jane , Sakowski Stacey A. , Glass Jonathan D. 
Published: February 2014

ObjectiveThe US Food and Drug Administration–approved trial, “A Phase 1, Open‐Label, First‐in‐Human, Feasibility and Safety Study of Human Spinal Cord‐Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis, Protocol Number: NS2008‐1,” is complete. Our overall objective was to assess the safety and feasibility of stem cell transplantation into lumbar and/or cervical spinal cord regions in amyotrophic lateral sclerosis (ALS) subjects.MethodsPreliminary results have been reported on the initial trial cohort of 12 ALS subjects. Here, we describe the safety and functional outcome monitoring results for the final trial cohort, consisting of 6 ALS subjects receiving 5 unilateral cervical intraspinal neural stem cell injections. Three of these subjects previously received 10 total bilateral lumbar injections as part of the earlier trial cohort. All injections utilized a novel spinal‐mounted stabilization and injection device to deliver 100,000 neural stem cells per injection, for a dosing range up to 1.5 million cells. Subject assessments included detailed pre‐ and postsurgical neurological outcome measures.ResultsThe cervical injection procedure was well tolerated and disease progression did not accelerate in any subject, verifying the safety and feasibility of cervical and dual‐targeting approaches. Analyses on outcome data revealed preliminary insight into potential windows of stem cell biological activity and identified clinical assessment measures that closely correlate with ALS Functional Rating Scale‐Revised scores, a standard assessment for ALS clinical trials.InterpretationThis is the first report of cervical and dual‐targeted intraspinal transplantation of neural stem cells in ALS subjects. This approach is feasible and well‐tolerated, supporting future trial phases examining therapeutic dosing and efficacy. Ann Neurol 2014;75:363–373
Rhodium‐Catalyzed CH Alkynylation of Arenes at Room Temperature
Authors: Feng Chao , Loh Teck‐Peng 
Published: February 2014

AbstractThe rhodium(III)‐catalyzed ortho CH alkynylation of non‐electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation.
A Chiral Gold Nanocluster Au20 Protected by Tetradentate Phosphine Ligands
Authors: Wan Xian‐Kai , Yuan Shang‐Fu , Lin Zhi‐Wei , Wang Quan‐Ming 
Published: February 2014

AbstractThe chirality of a gold nanocluster can be generated from either an intrinsically chiral inorganic core or an achiral inorganic core in a chiral environment. The first structural determination of a gold nanocluster containing an intrinsic chiral inorganic core is reported. The chiral gold nanocluster [Au20(PP3)4]Cl4 (PP3=tris(2‐(diphenylphosphino)ethyl)phosphine) has been prepared by the reduction of a gold(I)–tetraphosphine precursor in dichloromethane solution. Single‐crystal structural determination reveals that the cluster molecular structure has C3 symmetry. It consists of a Au20 core consolidated by four peripheral tetraphosphines. The Au20 core can be viewed as the combination of an icosahedral Au13 and a helical Y‐shaped Au7 motif. The identity of this Au20 cluster is confirmed by ESI‐MS. The chelation of multidentate phosphines enhances the stability of this Au20 cluster.
A new mutation in the CSB gene in a Chinese patient with mild Cockayne syndrome
Authors: Luo Yu , Ling Yan , Chen Jiachao , Xu Xi , Chen Chen , Leng Fei , Cheng Jing , Chen Min , Lu Zhiqiang 
Published: February 2014

Key Clinical MessageCockayne syndrome (CS) is a rare autosomal recessive genetic disease characterized by growth failure and progressive neurological degeneration. Here we report a mild form of CS patient who was homozygous for the C526T transition resulting in a new nonsense mutation, which converts Arg176 to a stop codon.
Carbon Dioxide Absorption in Triethanolamine Aqueous Solutions: Hydrodynamics and Mass Transfer
Authors: López Ana B. , La Rubia M. Dolores , Navaza José M. , Pacheco Rafael , Gómez‐Díaz Diego 
Published: February 2014

AbstractThe carbon dioxide absorption process by triethanolamine aqueous solutions was analyzed in a bubble‐column reactor taking into account the chemical reaction mechanism, gas‐liquid interfacial area, and mass transfer rate. A speciation study of this gas‐liquid system was developed by 1H and 13C NMR spectroscopy in order to obtain the reaction mechanism and stoichiometry. The gas‐liquid interfacial area was evaluated considering the variations of bubble size distribution and gas holdup during the operation time. The liquid‐phase mass transfer coefficient was calculated from the carbon dioxide absorption rate data by interfacial area evolution and reaction stoichiometry.
ChemInform Abstract: Structural Chemistry and Magnetic Properties of Nd18Li8Fe4M′O39 (M′: Al, Ga) and La18Li8Fe4,5In0.5O39.
Authors: Thammajak Nirawat , Battle Peter D. , Brown Catherine , Higgon Katharine , Stansfield Rhian 
Published: February 2014

AbstractThe title compounds are prepared by solid state reactions of Nd2O3 or La2O3, Fe2O3, M2O3 (M: Al, Ga, In), and excess Li2CO3 (alumina crucibles, 800 °C, 16 h).
ChemInform Abstract: Bi65Cu13Ge41O6Br122, a Low‐Valent Compound of High Structural Complexity Featuring the Trigonal Anion [O(GeIIBr2)3]2‐ with an sp2‐Hybridized μ3‐Oxide Ion.
Authors: Gerisch Alexander , Isaeva Anna , Ruck Michael 
Published: February 2014

Abstract(Bi5)2(Bi9)6 [O(GeBr2)3]6 [Cu6Ge5Br20] [BiCu7Ge18Br66] is obtained by very slow cooling of a melt of Bi, BiBr3, Cu, and partly oxidized Ge (1000 °C, 1 d, 1 K/h cooling rate).
ChemInform Abstract: Missing Links in the Sulfate Chemistry of Group 15 Elements: As(S2O7)(HS2O7), Sb2(SO4)2(S2O7) and Bi2(S2O7)3 from Reactions in Oleum under Harsh Conditions.
Authors: Logemann Christian , Kleineberg Henrike , Ohlert Jan , Wickleder Mathias S. 
Published: February 2014

AbstractSingle crystals of As(S2O7)(HS2O7) (I), Sb2(SO4)2(S2O7) (II), Bi2(S2O7)3 (III) are obtained from reactions of As2O3, SbCl3, and (BiO)2CO3 with oleum (65 % SO3) (evacuated glass tubes, 150 °C fo (I), 250 °C for (II) and (III), 24 h).
ChemInform Abstract: Crystal Structure of 3R‐LiTiS2 and Its Stability Compared to Other Polymorphs.
Authors: Nakhal Suliman , Lerch Martin , Koopman Jeroen , Islam Mazharul M. , Bredow Thomas 
Published: February 2014

Abstract3R‐LiTiS2 is prepared by heating a stoichiometric mixture of Ti, S, and Li2S (evacuated silica tubes, 800 °C, 2 weeks) with 10% of Li1+xTi2‐xO4 and TiO2 as byproducts followed by reheating in H2S (alumina crucible, 750 °C, 4 h).
ChemInform Abstract: AgCu3V4O12: A Novel Perovskite Containing Mixed‐Valence Silver Ions.
Authors: Akizuki Yasuhide , Yamada Ikuya , Fujita Koji , Akamatsu Hirofumi , Irifune Tetsuo , Tanaka Katsuhisa 
Published: February 2014

AbstractThe new title compound is prepared by solid state reaction of Ag2O, CuO, VO2, and V2O5 in the molar ratio 1:6:6:1 (Pt capsule, 15 GPa, 1373 K, 20 min).
ChemInform Abstract: Trichloromethyl Ketones: Asymmetric Transfer Hydrogenation and Subsequent Jocic‐Type Reactions with Amines.
Authors: Perryman Michael S. , Harris Matthew E. , Foster Jade L. , Joshi Anushka , Clarkson Guy J. , Fox David J. 
Published: February 2014

AbstractAsymmetric transfer hydrogenation of trichloromethyl ketones (I) is achieved using a Noyori‐type ruthenium‐complex as catalyst.
ChemInform Abstract: Pd‐Catalyzed Cyclization and Carbene Migratory Insertion: New Approach to 3‐Vinylindoles and 3‐Vinylbenzofurans.
Authors: Liu Zhenxing , Xia Ying , Zhou Shiyi , Wang Long , Zhang Yan , Wang Jianbo 
Published: February 2014

AbstractOne‐pot Pd‐catalyzed coupling of tosylhydrazones, generated in solution from the corresponding carbonyl compounds, with N‐propynyl‐2‐iodoamides or the analogous O‐propynyl‐2‐iodophenols offers a novel synthetic route to 3‐vinylindoles as well as 3‐vinylbenzofurans.
ChemInform Abstract: A Versatile Approach to Ullmann C—N Couplings at Room Temperature: New Families of Nucleophiles and Electrophiles for Photoinduced, Copper‐Catalyzed Processes.
Authors: Ziegler Daniel T. , Choi Junwon , Munoz‐Molina Jose Maria , Bissember Alex C. , Peters Jonas C. , Fu Gregory C. 
Published: February 2014

AbstractThis is a new coupling reaction of carbazoles, indoles, benzimidazoles, and imidazoles with various aryl and alkyl halides including hindered, deactivated, heterocyclic aryl iodides, alkenyl and alkynyl halides yielding N‐substituted heterocycles.
ChemInform Abstract: Increasing the Structural Span of Alkyne Metathesis.
Authors: Persich Peter , Llaveria Josep , Lhermet Rudy , de Haro Teresa , Stade Robert , Kondoh Azusa , Fuerstner Alois 
Published: February 2014

AbstractSeveral new catalysts for alkyne metathesis, e.g. MMC, are introduced.
ChemInform Abstract: Copper‐Mediated Deoxygenative Trifluoromethylation of Benzylic Xanthates: Generation of a C—CF3 Bond from an O‐Based Electrophile.
Authors: Zhu Lingui , Liu Shasha , Douglas Justin T. , Altman Ryan A. 
Published: February 2014

AbstractThe reaction is proposed to proceed via a radical cation intermediate.
ChemInform Abstract: A New Copper‐Based Metal—Organic Framework as a Promising Heterogeneous Catalyst for Chemo‐ and Regio‐Selective Enamination of β‐Ketoesters.
Authors: Zhao Ying , Deng Dong‐Sheng , Ma Lu‐Fang , Ji Bao‐Ming , Wang Li‐Ya 
Published: February 2014

AbstractA new metal‐organic framework derived from Cu(II), 5‐nitro‐1,2,3‐benzenetricarboxylic acid and a bis(triazolyl)propane is shown to be an efficient and recyclable heterogeneous catalyst for the highly selective enamination of β‐ketoesters (I) (11 examples).
ChemInform Abstract: Ruthenium‐Catalyzed Oxidative ortho‐Benzoxylation of Acetanilides with Aromatic Acids.
Authors: Padala Kishor , Jeganmohan Masilamani 
Published: February 2014

AbstractThe reaction of substituted acetanilides with aromatic acids proceeds in most cases regioselectively to afford 2‐benzoxylated acetanilides.
ChemInform Abstract: Electrophilic Intramolecular Cyclization of Functional Derivatives of Unsaturated Compounds. Part 4. Cyclosulfenylation of 5‐Hexenoic Acid Amides and Nucleophilic Cleavage of Reaction Products.
Authors: Vas'kevich A. I. , Tsizorik N. M. , Staninets V. I. , Vovk M. V. 
Published: February 2014

AbstractCompounds (I) react with arylsulfenyl chlorides (II) to give products of electrophilic cyclization (III).
ChemInform Abstract: Phosphine‐Catalyzed Rauhut—Currier Domino Reaction: A Facile Strategy for the Construction of Carbocyclic Spirooxindoles Skeletons.
Authors: Hu Chongchong , Zhang Qinglong , Huang You 
Published: February 2014

AbstractSpirocyclic compounds are constructed with the formation of two new C—C bonds and one quaternary carbon center in one step.
ChemInform Abstract: Facile and Green Syntheses of 2‐(N‐Methylindole‐3‐carbonyl)‐3‐(N‐methylpyrrol‐2‐yl)acrylonitriles (V) and a Study of Their Antimicrobial Activities.
Authors: Thirupathi G. , Venkatanarayana M. , Dubey P. K. , Kumari Y. Bharathi 
Published: February 2014

AbstractThe title compounds (V) and their precursors (III) show excellent antibacterial activities against Klebsiella pneumoniae and Escherichia coli as well as very good activity against Rhizoctonia solani and Fusarium oxysporum.
ChemInform Abstract: Magnetic Nanoparticle Supported Hyperbranched Polyglycerol Catalysts for Synthesis of 4H‐Benzo[b]pyran.
Authors: Nasseri Mohammad Ali , Sadeghzadeh Seyed Mohsen 
Published: February 2014

AbstractA newly synthesized catalyst effectively catalyzes the formation of benzopyran derivatives (IV) and (VI).