bluuebunny/crossref_metadata_2025_split huggingface dataset:
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3
Authors: Denes Adam , Coutts Graham , Lénárt Nikolett , Cruickshank Sheena M. , Pelegrin Pablo , Skinner Joanne , Rothwell Nancy , Allan Stuart M. , Brough David 
Published: March 2015

Significance
Cerebral ischemia (CI; stroke, brain injury, vascular dementia, neonatal hypoxia, and many other conditions) affects people at all stages of life. Of the many diseases associated with CI, stroke alone causes up to 10% of deaths worldwide and is a leading cause of disability; yet treatment options are extremely limited, so this represents an area of massive unmet clinical need. Inflammation involving the cytokine interleukin-1 is a major contributor to cell death in the ischemic brain. Inflammation can be regulated by large protein complexes called inflammasomes. Here we show that the NLRC4 (NLR family, CARD domain containing 4) and AIM2 (absent in melanoma 2) inflammasomes, but not the NLRP3 (NLR family, pyrin domain containing 3) inflammasome, contribute to inflammation and injury in an ischemic brain and are thus potential therapeutic targets for these devastating diseases.
Early Roman military fortifications and the origin of Trieste, Italy
Authors: Bernardini Federico , Vinci Giacomo , Horvat Jana , De Min Angelo , Forte Emanuele , Furlani Stefano , Lenaz Davide , Pipan Michele , Zhao Wenke , Sgambati Alessandro , Potleca Michele , Micheli Roberto , Fragiacomo Andrea , Tuniz Claudio 
Published: March 2015

Significance
Archaeological evidence from the Trieste area (Italy), revealed by airborne remote sensing and geophysical surveys, provides one of the earliest examples of Roman military fortifications. They are the only ones identified in Italy so far. Their origin is most likely related to the first year of the second Roman war against the Histri in 178 B.C., reported by Livy, but the sites were in use, perhaps not continuously, at least until the mid first century B.C. The main identified San Rocco military camp is the best candidate for the site of the first Trieste.
Cooperation and tensions in multiethnic corporate societies using Teotihuacan, Central Mexico, as a case study
Authors: Manzanilla Linda R. 
Published: March 2015

Significance
Teotihuacan was born as a complex multiethnic settlement that originally accommodated populations displaced by volcanic eruptions that devastated the southern Basin of Mexico. Soon, the city became an inclusive society where people from other regions of Mesoamerica could work mainly as qualified craftspeople (particularly garment makers and lapidary specialists), as well as builders, musicians, and military personnel. This society capitalized on the knowledge, technical expertise, and experience that foreigners brought to the city. Each neighborhood competed with the others in displaying the finest crafts, the rarest raw materials, and the most diverse sumptuary goods. This competition gave rise to a highly complex society, but one with inherent contradictions.
Activation of the factor XII-driven contact system in Alzheimer’s disease patient and mouse model plasma
Authors: Zamolodchikov Daria , Chen Zu-Lin , Conti Brooke A. , Renné Thomas , Strickland Sidney 
Published: March 2015

Significance
Alzheimer’s disease (AD) is a growing public health problem, in part because there are no effective therapies. Major roadblocks to the treatment of AD are the lack of adequate diagnostic tools and the absence of viable therapeutic targets. It is now clear that AD is characterized by inflammation. Our results indicate that AD patients and mouse models have increased activation of a set of proteins known as the contact activation system in their circulation. We also demonstrate that the AD-related peptide Aβ can initiate activation of this system in the circulation of animal models. Because the contact activation system contributes to inflammation, our results suggest new pathogenic mechanisms, diagnostic tests, and therapeutic targets for AD.
Ribosome–SRP–FtsY cotranslational targeting complex in the closed state
Authors: von Loeffelholz Ottilie , Jiang Qiyang , Ariosa Aileen , Karuppasamy Manikandan , Huard Karine , Berger Imre , Shan Shu-ou , Schaffitzel Christiane 
Published: March 2015

Significance
The universally conserved signal recognition particle (SRP) and its receptor (FtsY) deliver ∼30% of the proteome to the proper cellular membrane. To ensure proper timing and fidelity of targeting, SRP and FtsY adopt multiple conformations in a GTP-dependent manner. We solved the cryo-EM structure of the SRP–FtsY complex with a GTP analogue in the presence of a ribosome translating a signal sequence (the closed state) at 5.7 Å resolution. We describe the structural basis of ribosome and signal sequence binding by the SRP M domain. We demonstrate that in the closed state the SRP–FtsY GTPase domains are moving away from the ribosomal tunnel exit, allowing for translocon–ribosome interactions to accomplish cotranslational targeting.
Fast sensory–motor reactions in echolocating bats to sudden changes during the final buzz and prey intercept
Authors: Geberl Cornelia , Brinkløv Signe , Wiegrebe Lutz , Surlykke Annemarie 
Published: March 2015

Significance
Echolocating bats and toothed whales emit a terminal buzz right before capture. The high call rate (≥180 Hz) and short duration should preclude informed reactions, leaving the ubiquitous buzz an enigma. By removing prey from bats right before capture, we showed that the buzz is not inflexible but adaptable and that bats react on a very fast time scale to sudden changes in perceptual feedback. Acoustic and behavioral reactions differed, indicating separate central control of echolocation and capture movements, as well as importance of somatosensory feedback. These results in a naturally behaving animal relying on multimodal integration of actively controlled senses are significant for a central problem in neurobiology: fast decision making.
Diversity of regulatory mechanisms of photosynthetic carbon metabolism in plants and algae
Authors: Tamoi Masahiro , Shigeoka Shigeru 
Published: March 2015

Abstract
To clarify the regulatory mechanisms of the Calvin cycle in algae, we analyzed the molecular properties of the enzymes involved in this cycle. We demonstrated that these enzymes were not regulated by redox modulation through the ferredoxin/thioredoxin system under light/dark conditions and were not sensitive to treatments with hydrogen peroxide in vitro, unlike the chloroplastic thiol-modulated enzymes of plants. On the other hand, we found that cyanobacteria possessed a unique enzyme involved in the Calvin cycle. The CP12 protein played an important role in regulating carbon metabolism in the Calvin cycle in cyanobacteria and eukaryotic algae. This review described the regulatory mechanisms of the Calvin cycle in algae and also the effects of alterations to photosynthetic carbon metabolism on plant productivity, carbon partitioning, and the carbon/nitrogen balance using transgenic plants expressing algal genes.
Experimental demonstration of binary shaped pupil mask coronagraphs for telescopes with obscured pupils
Authors: Haze Kanae , Enya Keigo , Abe Lyu , Takahashi Aoi , Kotani Takayuki , Yamamuro Tomoyasu 
Published: March 2015

Abstract
We present the fabrication and experimental demonstration of three free-standing binary shaped pupil mask coronagraphs, which are applicable for telescopes with partially obscured pupils. Three masks, designed to be complementary (labeled Mask-A, Mask-B, and Mask-C), were formed in 5  μm thick nickel. The design of Mask-A is based on a one-dimensional barcode mask. The design principle of Mask-B is similar, but has a smaller inner working angle and a lower contrast than Mask-A. Mask-C is based on a concentric ring mask and provides the widest dark region and a symmetric point spread function. Mask-A and Mask-C were both designed to produce a flexibly tailored dark region (i.e., non-uniform contrast). The contrast was evaluated using a light source comprising a broadband super-luminescent light-emitting diode with a center wavelength of 650 nm, and the measurements were carried out in a large vacuum chamber. Active wavefront control was not applied in this work. The coronagraphic images obtained by experiment were mostly consistent with the designs. The contrast of Mask-A within the ranges 3.3–8 λ/D and 8–12 λ/D was ∼ 10−4–10−7 and ∼ 10−7, respectively, where λ is the wavelength and D is the pupil diameter. The contrast of Mask-B was ∼ 10−4 and that of Mask-C over an extended field of view (5–25 λ/D) was ∼ 10−5–10−6. The effect of tilting the masks was investigated, and found to be irrelevant at the ∼ 10−7 contrast level. Therefore the masks can be tilted to avoid ghosting. These high-contrast free-standing masks have the potential to enable coronagraphic imaging over a wide wavelength range using both ground-based and space-borne general-purpose telescopes with pupil structures not specifically designed for coronagraphy.
Isolation of Bordetella species from unusual infection sites
Authors: Almuzara Marisa , Barberis Claudia , Traglia Germán , Sly Gabriela , Procopio Adriana , Vilches Viviana , Ramirez Maria Soledad , Famiglietti Angela , Vay Carlos 
Published: March 2015

Introduction:

Bordetella hinzii has been isolated mainly from respiratory specimens and from blood of immunocompromised patients, and Bordetella trematum from ear infections or leg, arm and ankle wounds and from diabetic foot ulcers. Bordetella holmesii is instead associated with bactaeremia in young adults, mostly with underlying conditions. Only three septic arthritis cases due to this species have been described in the literature.

Case presentation:
Herein we describe four cases of infections due to Bordetella species that have been recovered from unusual infection sites: two cases of B. hinzii infections, one recovered from the urine of a patient with chronic prostatitis and the other from a liver cyst in an immunocompetent patient; one B. trematum case from a bone biopsy of a patient with chronic osteomyelitis of the hip; and one B. holmesii case isolated from the joint fluid of an immunocompetent patient with diagnosed septic arthritis. The organisms were identified using standard biochemical tests, by API 20 NE version 6.0, by automated system VITEK 2, by mass spectrometry using the Bruker Daltonics MicroFlex LT spectrometer with MALDI Biotyper 3.1, and by PCR amplification of 16S rRNA.
Antibiotic susceptibility testing was performed using the VITEK 2 system, except for B. holmesii, for which the epsilometric method (Etest technique; bioMérieux) was used.

Conclusion:
We highlight the importance of isolating Bordetella species from severe infections and unusual sites, and also of combining both phenotypic and genotypic methods for definitive identification.
The “New World” and international pâtisserie competition
Authors: Wood Yvonne Irene , Sturny Arno , Neill Lindsay , Brown Alan , Aprea Renny 
Published: March 2015

Purpose– The purpose of this paper is to illustrate how the New Zealand Junior Pastry Team negotiated the rigours of international competition at the 2013 Junior Pastry World Cup in Rimini, Italy and how what was learnt from this experience holds relevance to creative hospitality practice and business application.Design/methodology/approach– This paper uses an inductive qualitative enquiry to illuminate the narratives and subjective experiences of the competition team. Structured and semi-structured interview data responses were themed using an open coding system. This data were critically evaluated against both competition data, participant experience and relevant academic literature.Findings– This paper shows how the team’s desire to highlight its national identity through food in the competition resulted in problematic experiences that were compounded by a tyranny of distance. However, these challenges were overcome through the creative dynamic the team developed and the networking benefits which the competition provided. These experiences added value not only to the team competitors but also the culinary and pastry practitioners in New Zealand’s hospitality community.Originality/value– The research offers unique insights into how a representative pastry team from the “New World” negotiated international competition set in and heavily influenced by the “Old World” of culinary tradition. The paper’s findings could be of use to other novice competition teams. The work also links the importance of international culinary competition to wider constructs of hospitality, such as business advantage in commercial hospitality.
A web survey analysis of subjective well-being
Authors: Guzi Martin , de Pedraza García Pablo 
Published: March 2015

Purpose
– The purpose of this paper is to explore the role of work conditions and job characteristics with respect to three subjective well-being (SWB) indicators: life satisfaction, job satisfaction and satisfaction with work-life balance. From a methodological point of view, the paper shows how social sciences can benefit from the use of voluntary web survey data.

Design/methodology/approach
– The paper makes use of a large sample of individual data obtained from voluntary web surveys collected as part of the WageIndicator project. The sample includes extensive information on the quality of working conditions together with different well-being indicators. The propensity score adjustment weights are used to improve the sample performance.

Findings
– The results shed light on the importance of certain job characteristics not only in determining job satisfaction, but also in other SWB domains. The findings support the theory of spillover perspectives, according to which satisfaction in one domain affects other domains.

Research limitations/implications
– As a voluntary web-survey, WageIndicator is affected by selection bias. The validity of the sample can be improved by weighting, but this adjustment should be made and tested on a country-by-country basis.

Originality/value
– The paper provides analysis of the quality of a web survey not commonly used in happiness research. The subsequent presentation of the effects of working conditions on several satisfaction domains represents a contribution to the literature.
Health and well-being in the great recession
Authors: Askitas Nikolaos , Zimmermann Klaus F. 
Published: March 2015

Purpose– The purpose of this paper is to investigate the extent to which the authors can use internet search data in order to capture the impact of the 2008 Financial and Economic Crisis on well-being.Design/methodology/approach– The authors look at the G8 countries with a special focus on USA and Germany and investigate whether internet searches reflect the “malaise” caused by the crisis. The authors focus on searches that contain the word “symptoms” and are thought to proxy self-diagnosis and those that contain “side effects” and are thought to proxy treatment.Findings– The authors find that “malaise” searches spike in a fashion coincident with the crisis and its contagion timeline across the G8 countries. The authors show that results based on search recover previously known stylized facts from the economics of health, well-being and the business cycle.Research limitations/implications– Internet penetration is high across the G8 countries. The authors nonetheless cannot get a good handle on the part of the population, which is not online. Moreover the authors cannot get a good grip on all confounding factors. More research would be necessary with access to search microdata.Originality/value– The authors propose global proxies for diagnosis and treatment based on the “search buzz” for symptoms and side effects. The authors can thus capture trends on a global scale. This approach will become increasingly important.
Self-interest or the greater good
Authors: Marshall Donna , Ambrose Eamonn , McIvor Ronan , Lamming Richard 
Published: March 2015

Purpose– The purpose of this paper is to provide an understanding of the influence of political goals and behaviour on the outsourcing decision process and outcomes.Design/methodology/approach– The research used an exploratory longitudinal case-based approach. Eight outsourcing projects in three telecommunications companies were analysed from the initial decision to the outcome of the case.Findings– The authors show how political goals and behaviours influence the outsourcing decision process and inductively develop four political goals: personal reputation, attainment, elimination and control. The authors also identify three dynamic outsourcing paths: the personal reputation path, which leads to successful outcomes; the short-term attain and eliminate path leading to unsuccessful outcomes; and the destabilised path, which leads to mixed outcomes. All of these can be tested in other empirical settings.Research limitations/implications– The implications for outsourcing literature are that political intentions influence the decision process and outcomes. For theorists, the authors provide an understanding of how political and rational goals and behaviour interact to impact outsourcing outcomes: with political and rational goals and behaviour complementary in some instances. The limitations are that with a small sample the findings are generalisable to theoretical propositions rather than to a population.Practical implications– The implications for managers are the ability to identify and manage political goals that influence outsourcing decision process and outcomes.Originality/value– For the first time, the authors uncover the political goals that impact the outsourcing decision process and outcomes. The authors add to the outsourcing literature, transaction cost theory and resource-based theory by defining and understanding the political goals that complement these theories.
Who wins in a complex buyer-supplier relationship? A social exchange theory based dyadic study
Authors: Tanskanen Kari 
Published: March 2015

Purpose
– In complex buyer-supplier relationships (BSRs), contracts are always incomplete and many of the exchanges non-contractual. Because they occur over a long period of time and include unspecified obligations, non-contractual exchanges might be asymmetrical. The purpose of this paper is to examine BSRs with the aim of identifying the mechanisms that lead to asymmetry in exchanges.

Design/methodology/approach
– The author conducts an analysis, based on social exchange theory (SET), of six buyer-supplier dyads using the main SET constructs. From this multiple-case analysis the author develops a set of propositions explaining the exchange asymmetry in complex buyer-supplier relations.

Findings
– The results indicate that self-awareness of the determinants of attractiveness, use of power-balancing mechanisms, and primacy can explain the exchange asymmetry in BSRs.

Research limitations/implications
– The analysis is limited on the explanations for exchange asymmetry that are based on SET.

Practical implications
– The study highlights the importance of firms using the power-balancing mechanism in order to gain value from supply chain partners. The results show that firms can use attractiveness strategically to influence supply chain partners, but the author also observe that firms generally are not well aware of the determinants of their attractiveness in BSRs, which ignorance may pose a major obstacle to using attractiveness strategically.

Originality/value
– The paper provides the first systematic and comprehensive insight to social exchange mechanism in complex BSR. In this paper the author makes a major effort to clarify the basic assumptions and scope of the useful concepts and theoretical constructs of SET, and through a multiple-case study the author form a piece of substantive theory of SET in BSRs.
Centralised grocery supply chain planning: improved exception management
Authors: Alftan Annika , Kaipia Riikka , Loikkanen Lauri , Spens Karen 
Published: March 2015

Purpose
– The purpose of this paper is to present an operations model for retail replenishment collaboration and identifies its expected benefits and limitations for the members of a grocery supply chain.

Design/methodology/approach
– A case study is conducted on a development project between a grocery wholesaler and two grocery product suppliers. Data are collected through semi-structured interviews with key respondents from four different companies.

Findings
– Despite advances in collaborative practices in grocery supply chains, retail store replenishment management faces challenges. In particular, demand exceptions management is a challenge in the grocery industry. A replenishment model called Collaborative Buyer-Managed Forecasting (CBMF) creates a proactive planning approach and a platform for close collaboration in the supply chain. The centralised forecasting transforms retailer sales data into a plan which serves the whole supply chain by creating one-order forecast. The CBMF model facilitates efficient demand management, improves demand responsiveness and promotes better availability of products in retail stores.

Research limitations/implications
– CBMF provides a replenishment planning model for the whole supply chain. It is tested to a limited extent in one supply chain.

Practical implications
– The study provides managers with a better understanding of the benefits of centralised forecasting and closer replenishment collaboration, especially during periods of exceptional demand.

Originality/value
– A new approach for managing demand in grocery supply chains with centralised forecasting is provided.
On the relationship between purchasing integration and purchasing decision-making speed
Authors: Kaufmann Lutz , Gaeckler Julia 
Published: March 2015

Purpose– First, this study expands knowledge on the strategic decision process dimension decision-making speed by analyzing decision-making speed and two possible antecedents in a purchasing context. Second, it takes an additional step toward clarifying the relationship between strategic and lateral integration. Specifically, the purpose of this paper is to analyze the potential mediating effect of lateral purchasing integration on the relationship between strategic purchasing integration and purchasing decision-making speed.Design/methodology/approach– This research analyzes survey data of 152 firms from Austria, Germany, and Switzerland using covariance-based structural equation modeling.Findings– The results of the structural equation model provide strong support for the hypothesized relationships. Strategic purchasing integration drives lateral purchasing integration, which in turn positively influences purchasing decision-making speed.Research limitations/implications– This study focusses solely on internal types of integration. A logical next step would be to further enrich the model by including external dimensions, such as supplier or customer integration.Practical implications– This study should help managers gain a better understanding of the relationship between strategic and lateral purchasing integration, highlighting their positive impact on decision-making speed. Decision-making speed is particularly important for companies operating in volatile markets and time-constrained business environments.Originality/value– This study offers new insights into the theoretical and empirical connection between intra-organizational purchasing integration, unpacked as strategic purchasing integration and lateral purchasing integration, and purchasing decision-making speed. Furthermore, it offers insights into decision-making speed in a purchasing context.