bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional assessment and influencing factors after staged functional training in patients with ankle fractures
Authors: Fang Min-Qiong 
Published: June 2024

BACKGROUND
The recovery of limb function after ankle fracture surgery is a gradual process. The main purpose of implementing early functional exercise, joint mobility, muscle contraction function, passive ankle flexion and extension exercises, or physical factor therapy techniques is to achieve the rapid recovery of normal physiological limb function. However, currently the most effective rehabilitation training method is staged limb functional exercise, which promotes rapid recovery of limb function while preventing adverse consequences caused by overwork or insufficient training. Staged limb functional exercise divides the rehabilitation process into multiple stages, each of which has specific training objectives and contents. This method helps patients gradually restore limb function. Nevertheless, some patients still exhibit poor limb function after standardized exercise. Therefore, a functional evaluation should be performed to analyze the impact of staged functional training after ankle fracture surgery.
AIM
To perform a functional evaluation and determine the influencing factors of staged functional training in patients with ankle fracture.
METHODS
A retrospective study enrolled 150 patients who underwent surgical treatment for ankle fracture from May 2020 to May 2022 at our hospital. Univariate and multivariate linear regression analyses were performed on general data, functional exercise compliance scale for orthopedic patients, Social Support Rating Scale (SSRS), American Orthopedic Foot and Ankle Score (AOFAS) Ankle-Hindfoot Score, and pain factors [serum bradykinin (BK), prostaglandin E2 (PGE2), 5-hydroxytryptamine (5-HT)].
RESULTS
Based on the AOFAS Ankle-Hindfoot Scale, the cases were divided into the excellent function (n = 111) and ordinary function (n = 39) groups. Univariate analysis revealed that monthly family income, education level, diabetes mellitus, functional exercise compliance scale of orthopedic patients score, SSRS, BK, PGE2, and 5-HT significantly influenced limb function after ankle fracture (P < 0.05); Multiple linear regression analysis showed that the functional exercise compliance scale score, SSRS, BK, PGE2, and 5-HT were independent risk factors affecting functional performance after staged functional exercise (P < 0.05).
CONCLUSION
Exercise compliance, SSRS, and pain level are the independent risk factors affecting functional performance after staged functional training following ankle surgery. Clinical nursing care after ankle surgery should include analgesic and health education measures to ensure optimal recovery of limb function.
Effect of psychological nursing intervention combined with acupressure on postoperative recovery of women after cesarean section
Authors: Liu Xing-Ying , Chen Xiao-Bo , Wen You-Liang , Guo Xiao-Ping , Zhou Xiao-Bin 
Published: June 2024

BACKGROUND
Psychological intervention nursing (PIN) has been considered to have a curative effect on cesarean section (CS) postoperative recovery. However, the therapeutic mechanisms remain obscure.
AIM
To explore the effects of PIN combined with acupressure massage on CS postoperative recovery.
METHODS
A retrospective study was conducted on 150 pregnant women admitted to an obstetrics department between January 2020 and January 2023. The control group (CG) received acupressure therapy (n = 73), and the intervention group (IG) received acupressure therapy and PIN therapy (n = 77). Postoperative recovery time was assessed by anal-exhausting, defecation, bed activity, breastfeeding, and hospital stay times. Adverse effects, including infection, bleeding, limb numbness, intrauterine hematoma, urinary retention, and venous thromboembolism, were recorded. the pain visual analogue scale (VAS) was used to evaluate the degree of pain. Anxiety and depression status were qualitatively assessed using the self-rating anxiety scale (SAS), self-rating depression scale (SDS), and Edinburgh postpartum depression scale (EPDS). The Pittsburgh sleep quality index (PSQI) was used to compare sleep quality between the groups.
RESULTS
The baseline data and SAS, SDS, EPDS, and PSQI scores did not significantly differ before CS (P > 0.05) and neither did complication rates between the two groups after CS (P > 0.05). However, anal-exhausting, defecation, waking up, breastfeeding, and hospitalization times were significantly shorter for participants in the IG than those for participants in the CG (P < 0.05). The VAS, SAS, SDS, EPDS, and PSQI scores of the IG were significantly lower than those of the CG (P < 0.05).
CONCLUSION
PIN, combined with acupressure massage, effectively promotes maternal recovery, reduces post-CS pain, and improves postoperative negative emotions and sleeping quality.
Effect of electroacupuncture combined with rehabilitation techniques on shoulder function in patients with rotator cuff injuries
Authors: Chen Zhi-Ying , Wang Meng-Hua , Ye Zhong 
Published: June 2024

BACKGROUND
The rotator cuff is located below the acromion and deltoid muscles and comprises multiple tendons that wrap around the humeral head, maintaining shoulder joint stability.
AIM
To explore the effect of electroacupuncture combined with rehabilitation techniques on shoulder function in patients with rotator cuff injuries.
METHODS
We selected 97 patients with rotator cuff injuries treated in the People's Hospital of Yuhuan from February 2020 to May 2023. Patients were grouped using the envelope method.
RESULTS
After treatment, the study group’s treatment effective rate was 94.90% (46/49 patients), significantly higher than that in the control group (79.17%, 38/48 cases; P < 0.05). Before treatment, there was no difference in Constant Murley Score (CMS) scores, shoulder mobility, or 36-Item Short Form Health Survey (SF-36) scale scores (P > 0.05). Compared with those before treatment, the CMS scores (including pain, daily living ability, shoulder mobility, and muscle strength), all aspects of shoulder mobility (forward flexion, posterior extension, external rotation, internal rotation), and SF-36 scale scores (including physiological, psychological, emotional, physical, vitality, and health status) were higher in both groups after treatment and significantly higher in the study group (P < 0.05). There was no difference in the occurrence of complications between the two treatment groups (P > 0.05).
CONCLUSION
Electroacupuncture combined with rehabilitation techniques has a good treatment effect on patients with rotator cuff injuries, helps accelerate the recovery of shoulder function, improves the quality of life, and is highly safe.
Efficacy of percutaneous mechanical thrombus removal in acute lower extremity deep venous thrombosis
Authors: Xue Jun-Qiang , Yin Ping , He Jian-Ping , Wei Hui , Geng Cui-Jie , Luo Yu-Xian 
Published: June 2024

BACKGROUND
Acute lower extremity deep venous thrombosis (LEDVT) is a common vascular emergency with significant morbidity risks, including post-thrombotic syndrome (PTS) and pulmonary embolism. Traditional treatments like catheter-directed thrombolysis (CDT) often result in variable success rates and complications.
AIM
To investigate the therapeutic efficacy of percutaneous mechanical thrombus removal in acute LEDVT.
METHODS
A retrospective analysis was performed to examine 58 hospitalised patients with acute LEDVT between August 2019 and August 2022. The patients were categorised into the percutaneous mechanical thrombectomy (PMT) group (n = 24) and CDT group (n = 32). The follow-up, safety and treatment outcomes were compared between the two groups. The main observational indexes were venous patency score, thrombus removal effect, complications, hospitalisation duration and PTS.
RESULTS
The venous patency score was 9.04 ± 1.40 in the PMT group and 8.81 ± 1.60 in the CDT group, and the thrombus clearance rate was 100% in both groups. The complication rate was 8.33% in the PMT group and 34.84% in the CDT group, and the difference was statistically significant (P < 0.05). The average hospitalisation duration was 6.54 ± 2.48 days in the PMT group and 8.14 ± 3.56 days in the CDT group. The incidence of PTS was lower in the PMT group than in the CDT group; however, the difference was not statistically significant (P < 0.05).
CONCLUSION
Compared with CDT, treatment of LEDVT via PMT was associated with a better thrombus clearance rate, clinical therapeutic effect and PTS prevention function, but the difference was not statistically significant. Moreover, PMT was associated with a reduced urokinase dosage, shortened hospitalisation duration and reduced incidence of complications, such as infections and small haemorrhages. These results indicate that PMT has substantial beneficial effects in the treatment of LEDVT.
Efficacy and safety of Xileisan combined with mesalazine for ulcerative colitis: A meta-analysis and trial sequential analysis
Authors: Yang Xin-Yu , Yu Yun-Feng , Tong Ke-Ke , Hu Gang , Yu Rong , Su Lian-Jun 
Published: June 2024

BACKGROUND
The benefits and risks of Xileisan (XLS) in the treatment of ulcerative colitis (UC) remain unclear.
AIM
The present study aimed to evaluate the efficacy and safety of the combination of XLS and mesalazine when treating UC.
METHODS
We searched eight databases for clinical trials evaluating the combination of XLS and mesalazine in the treatment of UC, up to January 2024. Meta-analysis and trial sequential analysis (TSA) were performed using Revman 5.3 and TSA 0.9.5.10 beta, respectively.
RESULTS
The present study included 13 clinical studies involving 990 patients, of which 501 patients received XLS combined with mesalazine while 489 patients received mesalazine alone. The meta-analysis showed that, in terms of efficacy, the combination of XLS and mesalazine significantly improved the clinical efficacy rate by 22% [risk ratio (RR) = 1.22; 95%CI: 1.15–1.28; P < 0.00001] and mucosal improvement rate by 25% (RR = 1.25; 95%CI: 1.12–1.39; P = 0.0001), while significantly reducing the duration of abdominal pain by 2.25 days [mean difference (MD) = -2.25; 95%CI: -3.35 to -1.14; P < 0.0001], diarrhea by 2.06 days (MD = -2.06; 95%CI: -3.92 to -0.20; P = 0.03), hematochezia by 2.32 days (MD = -2.32; 95%CI: -4.02 to -0.62; P = 0.008), tumor necrosis factor alpha by 16.25 ng/mL (MD = -16.25; 95%CI: -20.48 to -12.01; P < 0.00001), and interleukin-6 by 14.14 ng/mL (MD = -14.14; 95%CI: -24.89 to -3.39; P = 0.01). The TSA indicated conclusiveness in the meta-analysis of the efficacy endpoints. In terms of safety, the meta-analysis revealed that the combination of XLS and mesalazine did not increase the occurrence of total and gastrointestinal adverse events, abdominal distension, and erythema (P > 0.05). The TSA showed non conclusive findings in the meta-analysis of the safety endpoints. Harbord’s test showed no publication bias (P = 0.734).
CONCLUSION
Treatment with XLS alleviated the clinical symptoms, intestinal mucosal injury, and inflammatory response in patients with UC, while demonstrating good safety.
Surgical treatment of a rare brachial artery aneurysm post-arteriovenous fistula closure after kidney transplant: A case report
Authors: Demirkan Nahit Arda , Keskin Yasemin , Sevinç Hakan , Çetinkaya Ömer Arda 
Published: June 2024

BACKGROUND
Brachial artery aneurysms are defined as dilations greater than 50% of the normal diameter, which are rare among all peripheral arterial aneurysms. While they are often present as pseudoaneurysms, true brachial artery aneurysms are also detected rarely. In this case report, the surgical repair method of true brachial artery aneurysms, which is a rare condition, is explained.
CASE SUMMARY
Herein, we present a 61-year-old male patient with complaints of swelling and pain in the right arm antecubital region that had been progressing over 6 mo. Upon the diagnosis of a true brachial artery aneurysm associated with arteriovenous fistula, the aneurysm was surgically repaired with an autologous saphenous vein graft. The patient was discharged without any neurovascular complications postoperatively.
CONCLUSION
True brachial artery aneurysms are rare and there are not any recommendations for their management in the current literature. Even though the treatment of true aneurysms in this artery is primarily based on a surgical treatment, endovascular repair also might be an option.
Primary large cell neuroendocrine carcinoma of the bladder: A case report
Authors: Bai Liang-Liang , Guo Yue-Xian , Song Shi-Yu , Li Ran , Jiang Yu-Qing 
Published: June 2024

BACKGROUND
Large cell neuroendocrine carcinoma (LCNEC) of the bladder is a rare non-urothelial tumor of the bladder. The treatment of LCNEC of the bladder is different from that of urothelial carcinoma (UC); therefore, early and accurate diagnosis is particularly important. As LCNEC of the bladder is rare and its clinical symptoms and radiographic features are similar to those of urothelial tumors, the clinical diagnosis of the disease remains challenging.
CASE SUMMARY
We report a 72-year-old female patient who presented with gross hematuria for 3 mo. A solitary tumor located in the anterior wall of the bladder was found by cystoscopy. Pathological examination after biopsy suggested UC of the bladder in the absence of immunohistochemical assessment. The patient underwent partial cystectomy and was finally diagnosed with LCNEC (pT2bN0M0) based on the results of postoperative immunohistochemical examination. During the 10-mo follow-up, no signs of tumor recurrence or metastasis were found.
CONCLUSION
Immunohistochemical examination is essential for diagnosing LCNEC of the bladder. Accurate diagnosis and multidisciplinary treatment in the early stage of the disease are crucial for improving the prognosis.
Spontaneous dislodgment of a peritoneal dialysis catheter inserted using the Seldinger technique: A case report
Authors: Wu Ruo-Yu , Tan Yao , Li Hang , Zou Yu-Rong , Chen Xiu-Ling , Chen Jin 
Published: June 2024

BACKGROUND
Peritoneal dialysis (PD) is an important renal replacement therapy in patients with end-stage renal disease. PD catheters remain the lifeline for patients undergoing PD. The catheter technique survival rate is considered a core PD outcome domain.
CASE SUMMARY
The PD catheter spontaneously dislodged in a patient undergoing PD during regular fluid exchange without pain. Abdominal computed tomography showed a tunnel infection. A double-cuff straight Tenckhoff catheter had been inserted using the Seldinger technique. Before this incident, the patient had a history of tunnel infections. We speculate that recurrent tunnel infections and catheter insertion using the Seldinger technique may have led to catheter dislodgement.
CONCLUSION
The present case suggests that clinicians should more rigorously assess the persistence of catheter-related infections concerning the potential complications arising from catheter dislodgement associated with the Seldinger technique.
Treatment of a patient with aconitine poisoning using veno-arterial membrane oxygenation: A case report
Authors: Bian Yu-Yao , Hou Jin , Khakurel Sudha 
Published: June 2024

BACKGROUND
Aconitine poisoning is highly prone to causing malignant arrhythmias. The elimination of aconitine from the body takes a considerable amount of time, and during this period, patients are at a significant risk of death due to malignant arrhythmias associated with aconitine poisoning.
CASE SUMMARY
A 30-year-old male patient was admitted due to accidental ingestion of aconitine-containing drugs. Upon arrival at the emergency department, the patient intermittently experienced malignant arrhythmias including ventricular tachycardia, ventricular fibrillation, ventricular premature beats, and cardiac arrest. Emergency interventions such as cardiopulmonary resuscitation and defibrillation were promptly administered. Additionally, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) therapy was initiated. Successful resuscitation was achieved before ECMO placement, but upon initiation of ECMO, the patient experienced recurrent malignant arrhythmias. ECMO was utilized to maintain hemodynamics and respiration, while continuous blood purification therapy for toxin clearance, mechanical ventilation, and hypothermic brain protection therapy were concurrently administered. On the third day of VA-ECMO support, the patient’s respiratory and hemodynamic status stabilized, with only frequent ventricular premature beats observed on electrocardiographic monitoring, and echocardiography indicated recovery of cardiac contractile function. On the fourth day, a significant reduction in toxin levels was observed, along with stable hemodynamic and respiratory functions. Following a successful pump-controlled retrograde trial occlusion test, ECMO assistance was terminated. The patient gradually improved postoperatively and achieved recovery. He was discharged 11 days later.
CONCLUSION
VA-ECMO can serve as a bridging resuscitation technique for patients with reversible malignant arrhythmias.
Vegetation diversity based on peat hydrological units for supporting cattle production in West Kalimantan, Indonesia
Authors: SETIAWAN DUTA , JAYANEGARA ANURAGA , NAHROWI NAHROWI , KUMALASARI NUR ROCHMAH 
Published: July 2024

Abstract. Setiawan D, Jayanegara A, Nahrowi, Kumalasari NR. 2024. Vegetation diversity based on peat hydrological units for supporting cattle production in West Kalimantan, Indonesia. Biodiversitas 25: 2011-2019. This study determined the characteristics of forage supply, composition, and diversity in various West Kalimantan Peat Hydrological Units (PHU) and the capacity for livestock development. The methods used were a combination of surveys, direct observations, and measurements of samples of peat hydrological units commonly used as pasture by farmers. The results showed that the pattern of providing forage for livestock is that the majority of farmers are in the productive age category (41-60 years), the education level was only elementary school, livestock farming was only a side business (78.33-81.67%), and the mowing capacity was still above livestock feed requirements. Important Value Index (IVI) in Mempawah Ageratum conyzoides (32.34%), Pontianak IVI Digitaria sanguinalis (27.17%), Kubu Raya IVI Cyperus brevifolius (22.43%). The forage species diversity index (H) of the three districts in West Kalimantan was classified as moderate or high. The species Richness Indices (R') for Mempawah, Pontianak, and Kubu Raya were 5.01, 6.22, and 6.41, respectively. The carrying capacity index in Kubu Raya (2.01) and Mempawah (5.19) was included in the safety criteria because it has a CCI above 2. In conclusion, The West Kalimantan livestock population can be increased by utilizing land in rice fields, dry fields, community forests, and plantations as a source of diverse forage vegetation.
The impact of ABCB1, CYP3A4 and CYP3A5 gene polymorphisms on apixaban trough concentration and bleeding risk in patients with atrial fibrillation
Authors: Skripka Alena I. , Krupenin Pavel M. , Kozhanova Olga N. , Kudryavtseva Anna A. , Fedina Ludmila V. , Akmalova Kristina A. , Bochkov Pavel O. , Sokolova Anastasiya A. , Napalkov Dmitriy A. , Sychev Dmitriy A. 
Published: June 2024

Abstract

Objectives
Apixaban, a direct oral anticoagulant, is increasingly used worldwide for the treatment and prevention of venous thromboembolism and ischemic stroke in patients with nonvalvular atrial fibrillation (AF). Obviously, one of the ways to enhance effectiveness and safety of drug therapy is a personalized approach to therapy, which involves pharmacogenetic and pharmacokinetic tests. The study aims to investigate the effect of CYP3A4*22, CYP3A5*3 and ABCB1 polymorphisms on the pharmacokinetics of apixaban and the risk of bleeding.

Methods
A total of 84 patients were enrolled in this prospective observational study. All patients received apixaban 5 or 2.5 mg twice daily. Real-time polymerase chain reaction was used to evaluate single-nucleotide polymorphisms of the ABCB1 gene (rs1045642 and rs4148738), CYP3A4*22 (rs35599367) C>T, CYP3A5*3 (rs776746) A>G. A plasma trough concentration/dose (C/D) ratio was used as a pharmacokinetic index.

Results
The C/D ratio was higher in patients aged >80 years (F(1)=11.209, p=0.00124) and was affected by serum creatinine (>133 μmol/L, F(1)=6.7, p=0.01124). ABCB1 (rs1045642 and rs4148738), CYP3A5 (rs776746) and CYP3A4 (rs35599367) polymorphisms did not show a correlation with C/D ratio of apixaban. Multivariate logistic regression analyses showed that none of the clinical or genetic factors predicted the fact of bleeding.

Conclusions
We report no significant association between ABCB1 gene polymorphisms (rs1045642 and rs4148738), CYP3A4*22 (rs35599367) C>T, CYP3A5*3 (rs776746) A>G and bleeding events on apixaban treatment. Complementing the existing criteria with pharmacogenetic and pharmacokinetics information for the patients with AF will enable further individualization of apixaban.
In search of a semiotic model for onomatopoeia
Authors: Körtvélyessy Lívia 
Published: June 2024

Abstract
In recent years, numerous publications on onomatopoeia have discussed this class of words either separately or as a part of a broader class of ideophones. Those focused on onomatopoeia usually provide a language-specific description primarily based on phonological, morphological and/or syntactic characteristics. Semiotically oriented papers generally discuss the nature of onomatopoeia against the background of Saussure’s conception of arbitrariness. What is missing is the representation of onomatopoeia in the main semiotic models. Therefore, this paper outlines the fundamental semiotic models and adapts them to capture the class of onomatopoeia. The paper covers Saussure’s dyadic model of linguistic sign, the triadic models of Peirce and Ogden and Richards, and a cognitive onomasiological model proposed by Horecký. The latter’s advantage is that it is a dynamic model with potential for adaptation to various word-formation processes, including onomatopoeia-formation.
Cytomegalovirus congenital infection: long-term outcomes in a valaciclovir treated population
Authors: Vicente Maria , Carocha Ana I. , Rijo Claúdia , Cohen Álvaro , Martins Maria L. 
Published: June 2024

Abstract

Objectives
This case series aims to evaluate the long-term outcomes of congenital cytomegalovirus (CMV) infection in a population treated with valaciclovir during pregnancy. The study focuses on assessing the prevalence of long-term sequelae in infants with confirmed CMV fetal infection.

Methods
A retrospective analysis was conducted on 33 pregnancies corresponding to 34 fetus with confirmed CMV congenital infection. They were followed from November 2004 to December 2020. Valaciclovir treatment was initiated after confirmation of fetal infection, and fetal outcomes were monitored through serial ultrasounds, neurosonography, and fetal magnetic resonance imaging (MRI). Postnatal assessments included: PCR confirmation, symptoms evaluation at birth, and long-term follow-up protocols for visual, auditory, and neurodevelopmental assessment.

Results
Therapy was started at a median gestational age of 24 weeks. Of the 34 newborns 79.4 % were asymptomatic at birth. Median follow-up time was 6 years and 32.35 % developed long-term sequelae. Neurosensorial hearing loss (SNHL) was the predominant sequelae. In the cases which developed sequelae 54.5 % had imaging findings, and all with major findings developed long-term sequelae.

Conclusions
In our treated population we had a higher asymptomatic rate at birth comparing with a non-treated population, similar to those found in previous studies. We had a long-term sequelae rate of 32.35 %, similar to recent studies on non-treated population, although we registered a slightly lower rate of SNHL. A larger multicenter studies with a longer follow-up time, where treatment is started in the first trimester, is of the utmost importance, so we can truly understand the correlation between these imaging findings, therapy and long-term sequelae.