bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Landscape of microRNAs in Bone Tumor: A Comprehensive Review in Recent Studies
Authors: Raoufinia Ramin , Afrasiabi Parisa , Dehghanpour Amir , Memarpour Sara , Hosseinian Sayyed Hadi Sayyed , Saburi Ehsan , Naghipoor Karim , Rezaei Samaneh , Haghmoradi Meisam , Keyhanvar Neda , Rostami Mehdi , Fakoor Farhad , Kazemi Mohammadali Izadpanah , Moghbeli Meysam , Rahimi Hamid Reza 
Published: July 2024

:
Cancer, the second greatest cause of mortality worldwide, frequently causes bone metastases
in patients with advanced-stage carcinomas such as prostate, breast, and lung cancer. The
existence of these metastases contributes to the occurrence of skeletal-related events (SREs),
which are defined by excessive pain, pathological fractures, hypercalcemia, and spinal cord compression.
These injurious incidents leave uncomfortably in each of the cancer patient’s life quality.
Primary bone cancers, including osteosarcoma (OS), chondrosarcoma (CS), and Ewing's sarcoma
(ES), have unclear origins. MicroRNA (miRNA) expression patterns have been changed in
primary bone cancers such as OS, CS, and ES, indicating a role in tumor development, invasion,
metastasis, and treatment response. These miRNAs are persistent in circulation and exhibit distinct
patterns in many forms of bone tumors, making them potential biomarkers for early detection
and treatment of such diseases. Given their crucial regulatory functions in various biological processes
and conditions, including cancer, this study aims to look at miRNAs' activities and possible
contributions to bone malignancies, focusing on OS, CS, and ES. In conclusion, miRNAs are
valuable tools for diagnosing, monitoring, and predicting OS, CS, and ES outcomes. Further research
is required to fully comprehend the intricate involvement of miRNAs in these bone cancers
and to develop effective miRNA-based treatments.
The Role of Induced Pluripotent Stem Cells in the Treatment of Stroke
Authors: Darban Yasaman Mehdizadeh , Askari Hamid , Ghasemi-Kasman Maryam , Yavarpour-Bali Hanie , Dehpanah Amirabbas , Gholizade Parnia , Nosratiyan Nasrin 
Published: July 2024

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Stroke is a neurological disorder with high disability and mortality rates. Almost 80% of
stroke cases are ischemic stroke, and the remaining are hemorrhagic stroke. The only approved treatment for ischemic stroke is thrombolysis and/or thrombectomy. However, these treatments cannot sufficiently relieve the disease outcome, and many patients remain disabled even after effective thrombolysis. Therefore, rehabilitative therapies are necessary to induce remodeling in the brain. Currently,
stem cell transplantation, especially via the use of induced pluripotent stem cells (iPSCs), is considered a promising alternative therapy for stimulating neurogenesis and brain remodeling. iPSCs are
generated from somatic cells by specific transcription factors. The biological functions of iPSCs are
similar to those of embryonic stem cells (ESCs), including immunomodulation, reduced cerebral blood
flow, cerebral edema, and autophagy. Although iPSC therapy plays a promising role in both hemorrhagic and ischemic stroke, its application is associated with certain limitations. Tumor formation,
immune rejection, stem cell survival, and migration are some concerns associated with stem cell therapy. Therefore, cell-free therapy as an alternative method can overcome these limitations. This study
reviews the therapeutic application of iPSCs in stroke models and the underlying mechanisms and
constraints of these cells. Moreover, cell-free therapy using exosomes, apoptotic bodies, and microvesicles as alternative treatments is discussed.
Cost Evaluation of the Ontario Virtual Urgent Care Pilot Program: Population-Based, Matched Cohort Study
Authors: Tarride Jean-Eric , Hall Justin N , Mondoux Shawn , Dainty Katie N , McCarron Joy , Paterson J Michael , Plumptre Lesley , Borgundvaag Emily , Ovens Howard , McLeod Shelley L 
Published: July 2024

Background
In 2020, the Ministry of Health (MoH) in Ontario, Canada, introduced a virtual urgent care (VUC) pilot program to provide alternative access to urgent care services and reduce the need for in-person emergency department (ED) visits for patients with low acuity health concerns.

Objective
This study aims to compare the 30-day costs associated with VUC and in-person ED encounters from an MoH perspective.

Methods
Using administrative data from Ontario (the most populous province of Canada), a population-based, matched cohort study of Ontarians who used VUC services from December 2020 to September 2021 was conducted. As it was expected that VUC and in-person ED users would be different, two cohorts of VUC users were defined: (1) those who were promptly referred to an ED by a VUC provider and subsequently presented to an ED within 72 hours (these patients were matched to in-person ED users with any discharge disposition) and (2) those seen by a VUC provider with no referral to an in-person ED (these patients were matched to patients who presented in-person to the ED and were discharged home by the ED physician). Bootstrap techniques were used to compare the 30-day mean costs of VUC (operational costs to set up the VUC program plus health care expenditures) versus in-person ED care (health care expenditures) from an MoH perspective. All costs are expressed in Canadian dollars (a currency exchange rate of CAD $1=US $0.76 is applicable).

Results
We matched 2129 patients who presented to an ED within 72 hours of VUC referral and 14,179 patients seen by a VUC provider without a referral to an ED. Our matched populations represented 99% (2129/2150) of eligible VUC patients referred to the ED by their VUC provider and 98% (14,179/14,498) of eligible VUC patients not referred to the ED by their VUC provider. Compared to matched in-person ED patients, 30-day costs per patient were significantly higher for the cohort of VUC patients who presented to an ED within 72 hours of VUC referral ($2805 vs $2299; difference of $506, 95% CI $139-$885) and significantly lower for the VUC cohort of patients who did not require ED referral ($907 vs $1270; difference of $362, 95% CI 284-$446). Overall, the absolute 30-day costs associated with the 2 VUC cohorts were $18.9 million (ie, $6.0 million + $12.9 million) versus $22.9 million ($4.9 million + $18.0 million) for the 2 in-person ED cohorts.

Conclusions
This costing evaluation supports the use of VUC as most complaints were addressed without referral to ED. Future research should evaluate targeted applications of VUC (eg, VUC models led by nurse practitioners or physician assistants with support from ED physicians) to inform future resource allocation and policy decisions.
The Use of Telepsychiatry Services in Emergency Settings: Scoping Review
Authors: Shalev Ligat , Eitan Renana , Rose Adam J 
Published: July 2024

Background
Telepsychiatry (TP), a live video meeting, has been implemented in many contexts and settings. It has a distinct advantage in the psychiatric emergency department (ED) setting, as it expedites expert assessments for psychiatric patients. However, limited knowledge exits for TP’s effectiveness in the ED setting, as well as the process of implementing TP in this setting.

Objective
This scoping review aimed to review the existing evidence for the administrative and clinical outcomes for TP in the ED setting and to identify the barriers and facilitators to implementing TP in this setting.

Methods
The scoping review was conducted according to the guidelines for the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). Three electronic databases were examined: PubMed, Embase, and Web of Science. The databases were searched from January 2013 to April 2023 for papers and their bibliography. A total of 2816 potentially relevant papers were retrieved from the initial search. Studies were screened and selected independently by 2 authors.

Results
A total of 11 articles were included. Ten papers reported on administrative and clinical outcomes of TP use in the ED setting and 1 on the barriers and facilitators of its implementation. TP is used in urban and rural areas and for settings with and with no on-site psychiatric services. Evidence shows that TP reduced waiting time for psychiatric evaluation, but in some studies, it was associated with prolonged total length of stay in the ED compared with in-person evaluation. Findings indicate lower admission rates in patients assessed with TP in the ED. Limited data were reported for TP costs, its use for involuntary commitment evaluations, and its use for particular subgroups of patients (eg, those with a particular diagnosis). A single paper examined TP implementation process in the ED, which explored the barriers and facilitators for implementation among patients and staff in a rural setting.

Conclusions
Based on the extant studies, TP seems to be generally feasible and acceptable to key stakeholders. However, this review detected a gap in the literature regarding TP’s effectiveness and implementation process in the ED setting. Specific attention should be paid to the examination of this service for specific groups of patients, as well as its use to enable assessments for possible involuntary commitment.
Bidirectional Associations Between Mental Health Disorders and Chronic Diabetic Complications in Individuals With Type 1 or Type 2 Diabetes
Authors: Watanabe Maya , Reynolds Evan L. , Banerjee Mousumi , Charles Morten , Mizokami-Stout Kara , Albright Dana , Ang Lynn , Lee Joyce M. , Pop-Busui Rodica , Feldman Eva L. , Callaghan Brian C. 
Published: July 2024

OBJECTIVE
To determine bidirectional associations between the timing of chronic diabetes complications (CDCs) and mental health disorders (MHDs) in individuals with type 1 or type 2 diabetes.

RESEARCH DESIGN AND METHODS
We used a nationally representative health care claims database to identify matched individuals with type 1 or 2 diabetes or without diabetes using a propensity score quasirandomization technique stratified by age (0–19, 20–39, 40–59, and ≥60 years). CDCs and MHDs were identified using ICD-9/10 codes. We fit Cox proportional hazards models with time-varying diagnoses of CDCs or MHDs to investigate their association with the hazard of developing MHDs or CDCs, respectively.

RESULTS
From 2001 to 2018, a total of 553,552 individuals were included (44,735 with type 1 diabetes, 152,187 with type 2 diabetes, and 356,630 without diabetes). We found that having a CDC increased the hazard of developing an MHD (hazard ratio [HR] 1.9–2.9; P &lt; 0.05, with higher HRs in older age strata), and having an MHD increased the hazard of developing a CDC (HR 1.4–2.5; P &lt; 0.05, with the highest HR in age stratum 0–19 years). In those aged &lt;60 years, individuals with type 1 diabetes were more likely to have CDCs, whereas individuals with type 2 diabetes were more likely to have MHDs. However, the relationship between CDCs and MHDs in either direction was not affected by diabetes type (P &gt; 0.05 for interaction effects).

CONCLUSIONS
We found a consistent bidirectional association between CDCs and MHDs across the life span, highlighting the important relationship between CDCs and MHDs. Prevention and treatment of either comorbidity may help reduce the risk of developing the other.
Effect of Kankrej Cow Urine Distillate and Panchgavya Supplementation on Growth Performance, Carcass Characteristics and Blood Biochemical Profile of Broiler Chickens
Authors: Patel H. V. , Patil S. S. , Pawar M. M. , Ankuya K. J. , Parmar R. S. , Modi C. P. , Ashwar B. K. 
Published: July 2024

A study was conducted during the month of December, 2023 and January, 2024 to evaluate the effect of cow urine distillate and Panchgavya supplementation on growth performance, nutrient digestibility, carcass characteristics and blood biochemical parameters of broiler chickens. A total of 200 day-old broiler chicks were uniformly distributed into four treatment groups with 50 birds per treatment for a period of 42 days. The dietary treatments were T1: Basal diet, T2: Basal diet+1 ml cow urine distillate (CUD) in drinking water bird-1 day-1, T3: Basal diet+1 ml Panchgavya in drinking water bird-1 day-1 and T4: Basal diet+50 mg of Commercial feed grade antibiotic (Tylosin phosphate) kg-1 of feed. Results revealed that the mean final body weight and body weight gain in broiler chickens were not influenced by the inclusion of CUD and Panchgavya. There was no effect on feed intake, nutrient digestibility, carcass characteristics and blood biochemical parameters due to CUD and Panchgavya supplementation in broiler chickens. The feed conversion ratio was better in Panchgavya and feed antibiotic groups than the control group. The serum cholesterol level was significantly (p<0.05) reduced in Panchgavya and feed antibiotic groups followed by CUD group than the control. It may be concluded that supplementation cow urine distillate and Panchgavya in broiler chickens did not influence growth performance, feed intake, nutrient digestibility, carcass characteristics and blood biochemical parameters. Panchgavya and feed antibiotic supplementation improved feed conversion ratio and reduced serum cholesterol level in broiler chickens.
BAURAN PEMASARAN DAN STRATEGI PENGEMBANGAN SUSU KAMBING (STUDI KASUS PADA KARYA ETAWA FARM BANYUWANGI)
Authors: Ton Sefri , Rahayu Ninik Sri , Slamet Risky 
Published: July 2024

The purpose of this study was to analyze the marketing mix and development strategy of goat milk at Karya Etawa Farm, Kalipuro District, Banyuwangi Regency. The research method is a case study using descriptive analysis data and SWOT analysis. Data were collected in April - July 2021. The results of the study showed that the marketing mix in Karya Etawa Farm includes (a) goat milk products produced have various flavors and good quality, (b) product prices follow competitors, (c) milk distribution is carried out either directly to consumers or through retailers, (d) promotional activities are carried out through face-to-face and sales promotions. The business development strategy can be carried out through (a) business owners utilizing and maintaining business locations to produce quality products and improve marketing networks, b) maintaining product quality by utilizing support and supervision from the government, (c) maintaining product quality and setting competitive market prices, (d) strengthening and expanding marketing network cooperation through resellers of goat milk products, (e) using more modern technology to produce quality products and raise interest in goat milk consumption. Keywords: marketing mix, goat milk, development strategies
PENGARUH KOMITMEN ORGANISASI, BUDAYA PERUSAHAAN, SELF EFFICACY TERHADAP KINERJA KARYAWAN PADA PT. DUTA INTIKA GIANYAR
Authors: Damayanti Ni , Putri Cokorda 
Published: July 2024

Keberlanjutan perusahaan terjadi tidak hanya karena menjaga kualitas barang tetapi juga membutuhkan sumber daya yang berkualitas. Jika karyawan mempunyai komitmen tinggi dalam perusahaan maka akan muwujudkan kinerja yang baik. Tidak hanya komitmen, budaya pada perusahaan juga memberi pengaruh pada kinerja karyawan. Jika perusahaan atau organisasi mempunyai budaya yang besar maka bisa menciptakan kinerja yang bagus untuk waktu yang lama. Karyawan bukan sekedar dipengaruhi oleh komitmen dan budaya melainkan juga dipengaruhi oleh self efficacy. Karyawan yang menjalankan tugasnya dengan adanya self efficacy yang besar artinya mereka mempunyai rasa yakin dan percaya diri terhadap kemampuan mereka sendiri. Tujuan dari penelitian ini agar kita bisa melihat pengaruh secara simultan dan parsial antara Komitmen Organisasi, Budaya Perusahaan, Dan Self Efficacy Terhadap Kinerja Karyawan. Penelitian ini dilakukan bagi PT. Duta Intika Gianyar yang beralamat pada Jl. Bypas Dharma Giri No. 888 Lingkungan Candi Baru Gianyar. Sampel pada penelitian ini ialah semua pegawai yang berada di PT. Duta Intika Gianyar. Populasi dari penelitian tersebut ialah semua pegawai yang berada di PT. Duta Intika Gianyar yang totalnya 31 orang. Jenis analisis yang diaplikasikan di metode ini adalah jenis penelitian kuantitatif. Prosedur penentapan sampel ini menerapkan metode sampling jenuh serta sistem analisis informasi yang dilaksanakan yaitu pengamatan, tanya jawab secara langsung, serta kuisioner. Observasi penelitian ini menyatakan Komitmen Organisasi menghasilkan dampak yang absolut serta penting pada Kinerja Karyawan. Budaya Perusahaan juga memberi dampak absolut serta penting pada Kinerja Karyawan. Self Efficacy memberi dampak absolut serta penting pada Kinerja Karyawan. Serta Komitmen Organisasi, Budaya Perusahaan, Dan Self Efficacy secara sinkron berdampak absolut serta penting Terhadap Kinerja Karyawan.
PROBLEMATIZAÇÕES DE PRÁTICAS PEDAGÓGICAS ESCOLARES E EDUCAÇÃO ANTIRRACISTA: a cultura africana e afro-brasileira na Lei 10639/2003
Authors: Alves de Souza Neuzi Herculina , Da Silva Ivanil Magalhães , Carvalho  dos Santos Farias Kátia Sebastiana 
Published: July 2024

Este artigo tem como objetivo problematizar a cultura africana e afro-brasileira por meio de práticas pedagógicas e formação continuada de professores, com vistas a uma educação antirracista, buscando-se a desnaturalização de conceitos estabelecidos no ambiente escolar, que reproduzem e reforçam a desigualdade étnico-racial. A pesquisa foi desenvolvida em um Programa de Pós-Graduação em Educação, de uma universidade federal localizada no norte do Brasil/Amazônia. Trata-se de estudo de natureza interventiva, adotando-se metodologia com elementos da pesquisa pós-crítica. O estudo contou com a participação de professores e equipe gestora. Foram realizados encontros que consistiram em momentos formativos para estudo, problematização e discussão da temática. Como instrumentos de coleta de dados, foram utilizados registros fotográficos e gravação de falas, tomando-se para análise as práticas pedagógicas desenvolvidas pelos professores durante e após os encontros formativos. Os resultados apontam que os participantes se utilizaram de práticas diferenciadas, desconstruindo práticas anteriores, especialmente aqueles que mais resistiam a combater o racismo, o preconceito e a discriminação, passando a valorizar a cultura africana e afro-brasileira através de suas práticas pedagógicas em sala de aula, buscando promover uma educação antirracista.
Palavras-chave: Educação antirracista. Formação continuada. Cultura africana e afro-brasileira. Práticas pedagógicas.
The Impact of Audit Committees and Chief Executive Officer Characteristics on Real Earnings Management
Authors: Sanders Stanley , Nugraheni Bernadia Linggar Yekti 
Published: July 2024

Earnings management is an opportunistic behavior influenced by many factors. However, previous studies have not extensively investigated the impact of audit committee mechanisms and Chief Executive Officer (CEO) characteristics on real earnings management. This study aims to analyze the impact of audit committee mechanisms and CEO characteristics on real earnings management. The study utilizes secondary data from manufacturing companies listed on the Indonesia Stock Exchange from 2020 to 2022. The audit committee mechanism is proxied by using two measurements i.e. the number of audit committee meetings and the educational background of the audit committee, Meanwhile, CEO characteristics are proxied by the gender and the CEO's tenure. By applying multiple regression, this study finds that the number of audit committee meetings and CEO’s tenure have significant negative effects on real earnings management. Meanwhile, the background of the audit committee does not affect real earnings management. Interestingly, this study finds that male CEOs decrease real earnings management. Therefore, this research provides evidence that the number of audit committee meetings and CEO’s tenure play significant roles in reducing opportunistic behavior in a company.
Opportunity to Use Artificial Intelligence in Medicine
Authors: Pop-Jordanova Nada 
Published: July 2024

Abstract
Over the past period different reports related to the artificial intelligence (AI) and machine learning used in everyday life have been growing intensely. However, the AI in our country is still very limited, especially in the field of medicine.
The aim of this article is to give some review about AI in medicine and the related fields based on published articles in PubMed and Psych Net. A research showed more than 9 thousand articles available at the mentioned databases.
After providing some historical data, different AI applications in different fields of medicine are discussed. Finally, some limitations and ethical implications are discussed.
Specific Features of Diagnostic and Treatment Tactics in Patients with Crushed Abdominal Hernias Without Resection of a Hollow Organ
Authors: Slonetskyi Boris Ivanovich , Verbitskiy Igor Volodimirovich , Kotsiubenko Valeria Olegivna 
Published: July 2024

Abstract

The purpose of the work is to analyze the results of the use of optimized diagnostic and therapeutic tactics in patients with strangulated abdominal hernias without resection of the hollow organ.

Materials and methods: The work is based on the analysis of the results of surgical treatment of 665 patients with strangulated abdominal hernias without resection of the hollow organ, who were divided into 2 groups depending on the features of the diagnostic and treatment tactics. Unlike the patients of group 1, the following diagnostic tactics were used in group 2: substantiated laparoscopic diagnosis of abdominal organs; mandatory biochemical assessment of hernia water; mandatory intraoperative instrumental assessment of the state of the strangulated organ; expansion of indications for the use of laparoscopic interventions and components of the comprehensive Fast track program; substantiated complex prevention of malignancy. The clinical diagnostic algorithm included laboratory, instrumental and biochemical research methods.

Results: The use of priority diagnostic and therapeutic tactics in the patients of group 2 allowed to increase the number of laparoscopic hernioplasty by 49.34%, the number of allohernioplasty by 18.62%, among which the “Sublay” technique was preferred for strangulated ventral hernias. This was accompanied by a decrease in the pain syndrome on the VAS scale during the four days of observation, both during coughing and at rest, and amounted to only 2.21 ± 0.29 points on the fourth day when at rest. In addition, and after 12 months, the patients of group 2 observed a better recovery according to the SF-36 questionnaire, which amounted to 76.77±6.63 points for the assessment of the general state of health, 70.81±5.86 points for the assessment of physical functioning, 68.88±5.37 points for the assessment of role functioning due to physical condition, 68.03±5.92 points for the assessment of role functioning due to emotional state, and social activity was characterized by 72.82±5.52 points.
Conclusions: 1. The proposed diagnostic and treatment tactics in the patients of group 2 with strangulated abdominal hernias without resection of a hollow organ, in contrast to patients in group 1, made it possible to increase the number of laparoscopic operations to 227 (66.37%) in contrast to 55 (17.03%) in the first group, which was accompanied by a decrease in pain syndrome on the VAS scale on the fourth day when coughing from 4.35 ± 0.38 points to 2.97 ± 0.43 points.
2. The expansion of indications for the use of laparoscopic operations in patients of group 2, in contrast to patients of group 1, led to a decrease in the postoperative complications by 10.48% and the postoperative mortality by 2.29% and was characterized by better postoperative rehabilitation according to the assessment of the patients’ condition after 12 months according to the SF-36 questionnaire..