bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Participation Restriction Among US Adults With Arthritis: A Population‐Based Study Using the International Classification of Functioning, Disability and Health
Authors: Theis K. A. , Murphy L. , Hootman J. M. , Wilkie R. 
Published: February 2013

ObjectiveTo examine arthritis impact among US adults with self‐reported doctor‐diagnosed arthritis using the International Classification of Functioning, Disability and Health (ICF) framework (including the impairments, activity limitations, environmental, and personal factors domains and social participation restriction [SPR] as the outcome) overall and among those with and without SPR, and to identify the correlates of SPR.MethodsCross‐sectional 2009 National Health Interview Survey data were analyzed to examine the distribution of the ICF domain components. Unadjusted and multivariable‐adjusted prevalence ratios (PRs) and 95% confidence intervals (95% CIs) were estimated to identify the correlates of SPR. Analyses using SAS, version 9.2 survey procedures accounted for the complex sample design.ResultsSPR prevalence was 11% of adults with arthritis (5.7 million). After initial multivariable adjustment by ICF domain, serious psychological distress (impairments domain; PR 2.5 [95% CI 2.0–3.2]), ≥5 medical office visits (environmental domain; PR 3.4 [95% CI 2.5–4.4]), and physical inactivity (personal domain; PR 4.8 [95% CI 3.6–6.4]) were most strongly associated with SPR. A combined measure (key limitations [walking, standing, or carrying]; PR 31.2 [95% CI 22.3–43.5]) represented the activity limitations domain. After final multivariable adjustment incorporating all ICF domains simultaneously, the strongest associations with SPR were key limitations (PR 24.3 [95% CI 16.8–35.1]), ≥9 hours of sleep (PR 1.6 [95% CI 1.3–2.0]), and income‐to‐poverty ratio <2.00 and severe joint pain (PR 1.4 [95% CI 1.2–1.6] for both).ConclusionSPR affects 1 of 9 adults with arthritis. This study is the first to use the ICF framework in a population‐based sample to identify specific functional activities, pain, sleep, and other areas as priorities for intervention to reduce negative arthritis impacts on disability, including SPR. Increased use of existing clinical and public health interventions is warranted.
Potential Classification Criteria for Rheumatoid Arthritis After Two Years: Results From a French Multicenter Cohort
Authors: Saraux Alain , Tobón Gabriel J. , Benhamou Mathilde , Devauchelle‐Pensec Valérie , Dougados Maxime , Mariette Xavier , Berenbaum Francis , Chiocchia Gilles , Rat Anne‐Christine , Schaeverbeke Thierry , Rincheval Nathalie , Meyer Olivier , Fautrel Bruno , Combe Bernard 
Published: February 2013

ObjectiveTo determine agreement among the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria, a diagnosis of rheumatoid arthritis (RA) by a rheumatologist, and other criteria previously used to classify arthritis.MethodsWe used a nationwide longitudinal prospective cohort of patients with recent‐onset arthritis. After 2 years, the patients were classified as receiving disease‐modifying antirheumatic drugs (DMARDs), having synovitis, having joint erosions typical of RA, having a rheumatologist diagnosis of RA with >50.0% certainty, having a no better alternative diagnosis with >50.0% certainty, and having a diagnosis of RA using the 1987 ACR criteria and the 2010 ACR/EULAR criteria. Agreement among these criteria was assessed based on Cohen's kappa coefficient, where ≥0.80 = excellent, 0.60–0.79 = good, 0.40–0.59 = moderate, and <0.40 = poor.ResultsOf the 692 evaluated patients, 544 (78.6%) had persistent arthritis (defined as synovitis, ongoing DMARD treatment, or both) after 2 years. Among these 544 patients, 496 (91.2%) were receiving DMARDs. Agreement among all criteria was poor (estimated κ = 0.09–0.43), except when including a rheumatologist diagnosis of RA with >50.0% certainty or a no better alternative diagnosis with >50.0% certainty (estimated κ = 0.69–0.81). The strongest associations with a rheumatologist diagnosis of RA with >50.0% certainty were the 2010 ACR/EULAR criteria and the combination of no better alternative diagnosis, persistent arthritis, 1987 ACR criteria, and positive anti–citrullinated protein antibody.ConclusionRheumatologist diagnosis of RA with >50.0% certainty after 2 years agreed well with the 2010 ACR/EULAR criteria or a combination of items including no better alternative diagnosis, confirming high value as classification criteria after 2 years of followup.
Passivity analysis for nonlinear, nonstationary entry capsules
Authors: Mooij E. 
Published: February 2013

SUMMARYApplication of simple adaptive control theory to the design of guidance and control systems for winged re‐entry vehicles has been proven successful, despite the fact that the sufficient conditions of passivity are not fulfilled throughout the trajectory. This has been traced back to the hybrid control, that is, a combination of reaction and aerodynamic control for a single axis of motion, as well as a zero bank angle in the initial phase of the mission. The latter condition makes the vehicle nonminimum phase (positive transmission zeros of the open‐loop system). To further analyze the passivity of nonlinear, time‐varying systems, we study an entry capsule that enters the atmosphere in a lift‐down configuration to avoid skipping flight. The capsule is controlled by a reaction control system only. The transient effect (i.e., time‐varying aspects) is an important factor in the stability properties of the guidance system, and an analysis methodology has been set up to take both the nonlinearities and the time‐varying aspects due to the strongly changing flight regimes into account. Deriving the passivity conditions for translational motion, as well as evaluating these conditions along the trajectory, shows that the entry capsule is not almost strictly passive and the sufficient conditions are not met. The guidance‐system design should be augmented with parallel feedforward filters. For rotational motion, on the other hand, it is found the entry capsule is almost strictly passive, so the sufficient conditions to apply simple adaptive control are met.Copyright © 2013 John Wiley & Sons, Ltd.
Classification of Lattice Defects in the Kesterite Cu2ZnSnS4 and Cu2ZnSnSe4 Earth‐Abundant Solar Cell Absorbers
Authors: Chen Shiyou , Walsh Aron , Gong Xin‐Gao , Wei Su‐Huai 
Published: February 2013

AbstractThe kesterite‐structured semiconductors Cu2ZnSnS4 and Cu2ZnSnSe4 are drawing considerable attention recently as the active layers in earth‐abundant low‐cost thin‐film solar cells. The additional number of elements in these quaternary compounds, relative to binary and ternary semiconductors, results in increased flexibility in the material properties. Conversely, a large variety of intrinsic lattice defects can also be formed, which have important influence on their optical and electrical properties, and hence their photovoltaic performance. Experimental identification of these defects is currently limited due to poor sample quality. Here recent theoretical research on defect formation and ionization in kesterite materials is reviewed based on new systematic calculations, and compared with the better studied chalcopyrite materials CuGaSe2 and CuInSe2. Four features are revealed and highlighted: (i) the strong phase‐competition between the kesterites and the coexisting secondary compounds; (ii) the intrinsic p‐type conductivity determined by the high population of acceptor CuZn antisites and Cu vacancies, and their dependence on the Cu/(Zn+Sn) and Zn/Sn ratio; (iii) the role of charge‐compensated defect clusters such as [2CuZn+SnZn], [VCu+ZnCu] and [ZnSn+2ZnCu] and their contribution to non‐stoichiometry; (iv) the electron‐trapping effect of the abundant [2CuZn+SnZn] clusters, especially in Cu2ZnSnS4. The calculated properties explain the experimental observation that Cu poor and Zn rich conditions (Cu/(Zn+Sn) ≈ 0.8 and Zn/Sn ≈ 1.2) result in the highest solar cell efficiency, as well as suggesting an efficiency limitation in Cu2ZnSn(S,Se)4 cells when the S composition is high.
Application of Tertiary Amines Synthesized by Catalytic Dehydrogenation of Enamines as Nucleophilic C2 Synthons for 1,4‐Conjugate Addition with Fluoroalkylated Olefins
Authors: Morigaki Atsunori , Kawamura Mio , Arimitsu Satoru , Ishihara Takashi , Konno Tsutomu 
Published: February 2013

AbstractA catalytic amount of Pd(OAc)2 was successfully applied for the generation of enamines from various tertiary amines under oxidative conditions. As a synthetic application, the generated enamines were used for 1,4‐conjugate addition reactions with fluoroalkylated olefins. Thus, a catalytic amount of Pd(OAc)2 was added to a mixture of tertiary amines and fluoroalkylated olefins in N,N,‐dimethylacetamide in air, and the corresponding 1,4‐adducts were obtained in moderate to good yields for a variety of substrates. This unique reaction can allow readily available tertiary amines to be used as nucleophilic C2 synthons and is an alternative synthetic protocol for the hydroformylmethylation of olefins.
Invasive dynamics of the crayfish Procambarus clarkii (Girard, 1852) in the international section of the River Minho (NW of the Iberian Peninsula)
Authors: Sousa Ronaldo , Freitas Fabiana E. P. , Mota Micaela , Nogueira António J. A. , Antunes Carlos 
Published: February 2013

ABSTRACT

Procambarus clarkii (Girard, 1852) is a well‐established invasive species in many worldwide aquatic ecosystems and is responsible for several ecological and economic impacts. This study examines the major factors responsible for its invasive dynamics in the international section of the River Minho (north‐west Iberian Peninsula).
Data collected from June 2007 to May 2011 showed that abundance and biomass increased in the first 3 years of sampling, but suffered a decrease in the fourth year. Higher abundance and biomass were always found from May to October. These higher values have a clear relationship with water temperature and probably reflect higher activity and mobility.
The sex‐ratio was 1.08:1 in favour of females; eggs start to appear in May/June and the majority of juveniles in August/September.
Information collected in this study is extremely important for future management actions that could be applied to this invasive species. Accordingly, we propose that control actions to minimize P. clarkii impacts in this system, such as intensive trapping, should be applied during late spring/early summer, when the catches are higher, the females are dominant, and before juvenile recruitment. Copyright © 2013 John Wiley & Sons, Ltd.
Proteomic Analysis of Synovial Fluid From the Osteoarthritic Knee: Comparison With Transcriptome Analyses of Joint Tissues
Authors: Ritter Susan Y. , Subbaiah Roopashree , Bebek Gurkan , Crish James , Scanzello Carla R. , Krastins Bryan , Sarracino David , Lopez Mary F. , Crow Mary K. , Aigner Thomas , Goldring Mary B. , Goldring Steven R. , Lee David M. , Gobezie Reuben , Aliprantis Antonios O. 
Published: February 2013

AbstractObjectiveThe pathophysiology of the most common joint disease, osteoarthritis (OA), remains poorly understood. Since synovial fluid (SF) bathes joint cartilage and synovium, we reasoned that a comparative analysis of its protein constituents in health and OA could identify pathways involved in joint damage. We undertook this study to perform a proteomic analysis of knee SF from OA patients and control subjects and to compare the results to microarray expression data from cartilage and synovium.MethodsAge‐matched knee SF samples from 10 control subjects, 10 patients with early‐stage OA, and 10 patients with late‐stage OA were compared using 2‐dimensional difference‐in‐gel electrophoresis and mass spectrometry (MS). MS with a multiplexed peptide selected reaction monitoring assay was used to confirm differential expression of a subset of proteins in an independent OA patient cohort. Proteomic results were analyzed by Ingenuity Pathways Analysis and compared to published synovial tissue and cartilage messenger RNA profiles.ResultsSixty‐six proteins were differentially present in healthy and OA SF. Three major pathways were identified among these proteins: the acute‐phase response signaling pathway, the complement pathway, and the coagulation pathway. Differential expression of 5 proteins was confirmed by selected reaction monitoring assay. A focused analysis of transcripts corresponding to the differentially present proteins indicated that both synovial and cartilage tissues may contribute to the OA SF proteome.ConclusionProteins involved in the acute‐phase response signaling pathway, the complement pathway, and the coagulation pathway are differentially regulated in SF from OA patients, suggesting that they contribute to joint damage. Validation of these pathways and their utility as biomarkers or therapeutic targets in OA is warranted.
Identification of Citrullinated Hsp90 Isoforms as Novel Autoantigens in Rheumatoid Arthritis–Associated Interstitial Lung Disease
Authors: Harlow Lisa , Rosas Ivan O. , Gochuico Bernadette R. , Mikuls Ted R. , Dellaripa Paul F. , Oddis Chester V. , Ascherman Dana P. 
Published: February 2013

AbstractObjectiveSubsets of patients with rheumatoid arthritis (RA) develop extraarticular complications that include interstitial lung disease (ILD). Because standardized algorithms for identification of RA patients at risk of developing clinically significant ILD are lacking, the purpose of this study was to elucidate unique serologic markers of RA‐associated ILD (RA‐ILD).MethodsSera from RA patients with ILD and from RA patients without ILD were used to immunoprecipitate citrullinated and uncitrullinated proteins derived from K562 cell extracts. Mass spectrometry was performed to facilitate identification of citrullinated proteins differentially immunoprecipitated by RA‐ILD patient sera. These candidate proteins were then used as substrate antigens in custom enzyme‐linked immunosorbent assays (ELISAs) for high‐throughput screening of sera obtained from cohorts of patients with RA, RA‐ILD mixed connective tissue disease (MCTD), or idiopathic pulmonary fibrosis (IPF).ResultsDifferential immunoprecipitation and subsequent mass spectrometric sequencing identified citrullinated Hsp90α and citrullinated Hsp90β as candidate autoantigens in patients with RA‐ILD. ELISAs incorporating uncitrullinated and citrullinated isoforms of Hsp90 as substrate antigens demonstrated that sera from patients with RA‐ILD preferentially recognized citrullinated versions of Hsp90 with moderate sensitivity (range 20–30%) and great specificity (>95%) relative to sera derived from patients with RA alone (without ILD), patients with MCTD, or patients with IPF.ConclusionThese studies demonstrate the utility of a novel autoantigen discovery method based on differential immunoprecipitation of citrullinated protein extracts. Application of these techniques identified citrullinated versions of Hsp90α and Hsp90β as autoantibody targets distinguishing RA‐ILD from RA without ILD, MCTD, and IPF, suggesting that anti–citrullinated Hsp90α/β autoantibodies may serve as effective biomarkers for the potentially devastating pulmonary manifestations of RA‐ILD.
Normalization of Widespread Pressure Pain Hypersensitivity After Total Hip Replacement in Patients With Hip Osteoarthritis Is Associated With Clinical and Functional Improvements
Authors: Aranda‐Villalobos Pilar , Fernández‐de‐las‐Peñas César , Navarro‐Espigares Jose L. , Hernández‐Torres Elisa , Villalobos Mercedes , Arendt‐Nielsen Lars , Arroyo‐Morales Manuel 
Published: February 2013

AbstractObjectiveTo evaluate the relevance of ongoing nociceptive joint inputs to the maintenance of widespread pain hypersensitivity in patients with hip osteoarthritis (OA) and to determine whether a reversal in the widespread pressure hypersensitivity together with an improvement in pain and function occurs after total hip replacement in these patients.MethodsForty patients with hip OA participated. Twenty patients underwent total hip replacement, and the other 20 patients were assigned to a waiting list. Pressure–pain thresholds (PPTs) over the second metacarpal bone and the gluteus medius, vastus medialis, vastus lateralis, and tibialis anterior muscles were assessed bilaterally with a pressure algometer before and 3 months after total hip replacement surgery. Assessments of pain intensity (by visual analog scale [VAS]), physical function (by the Western Ontario and McMaster Universities Osteoarthritis Index), and health status (by the Short Form 12 health survey and the EuroQol 5‐domain index) were also performed.ResultsPatients who underwent total hip arthroplasty exhibited a reduction in widespread pressure pain hyperalgesia (increases in PPTs) over local and distant pain‐free areas, as compared with before surgery and as compared with the patients assigned to the waiting list. PPTs were related to hip pain intensity, and significant correlations were found between higher VAS scores and lower average PPTs over all points assessed (−0.409 < r < −0.306, P < 0.05). Patients who underwent total hip arthroplasty exhibited a greater decrease in pain intensity and greater increases in function and health status than did those who were on the waiting list. Changes in the intensity of hip pain were moderately associated with changes in pressure pain sensitivity in the hip arthroplasty group.ConclusionNormalization of widespread pressure pain hyperalgesia was found after successful hip joint replacement in patients with hip OA. Altered pain processing seems to be driven by ongoing peripheral joint pathology, which stresses the importance of reducing pain in OA.
Variants in RUNX3 Contribute to Susceptibility to Psoriatic Arthritis, Exhibiting Further Common Ground With Ankylosing Spondylitis
Authors: Apel Maria , Uebe Steffen , Bowes John , Giardina Emiliano , Korendowych Eleanor , Juneblad Kristina , Pasutto Francesca , Ekici Arif B. , McManus Ross , Ho Pauline , Bruce Ian N. , Ryan Anthony W. , Behrens Frank , Böhm Beate , Traupe Heiko , Lohmann Jörg , Gieger Christian , Wichmann Heinz‐Erich , Padyukov Leonid , FitzGerald Oliver , Alenius Gerd‐Marie , McHugh Neil J. , Novelli Giuseppe , Burkhardt Harald , Barton Anne , Reis André , Hüffmeier Ulrike 
Published: February 2013

AbstractObjectivePsoriatic arthritis (PsA) is a common inflammatory joint disease distinct from other chronic arthritides and frequently accompanied by psoriasis vulgaris. In a first genome‐wide association study (GWAS), we were able to identify several genetic risk factors. However, even combined with previously identified factors, the genetic contribution to disease was not fully explained. Therefore, we undertook this study to investigate further 17 loci from our GWAS that did not reach genome‐wide significance levels of association in the initial analysis.MethodsTwenty‐one of 22 single‐nucleotide polymorphisms were successfully genotyped in independent cohorts of 1,398 PsA patients and 6,389 controls and in a group of 964 German patients with psoriasis vulgaris.ResultsAssociation with a RUNX3 variant, rs4649038, was replicated in independent patients and controls and resulted in a combined P value of 1.40 × 10−8 by Cochran‐Mantel‐Haenszel test and an odds ratio (OR) of 1.24 (95% confidence interval [95% CI] 1.15–1.33). Further analyses based on linkage disequilibrium (LD) at RUNX3 refined the most significant association to an LD block located in the first intron of one isoform. Weaker evidence for association was detected in German patients with psoriasis vulgaris (P = 5.89 × 10−2; OR 1.13 [95% CI 1.00–1.28]), indicating a role in the skin manifestations of psoriasis.ConclusionOur analyses identified variants in RUNX3 as susceptibility factors for PsA. RUNX3 has already been implicated in susceptibility to ankylosing spondylitis, another spondyloarthritis, although its risk allele is independent from the one for PsA. RUNX‐3 is involved in CD8+ T lymphocyte differentiation and is therefore a good candidate for involvement in PsA and psoriasis vulgaris as T cell–mediated diseases.
Increased Expression of Endoplasmic Reticulum Stress and Unfolded Protein Response Genes in Peripheral Blood Mononuclear Cells From Patients With Limited Cutaneous Systemic Sclerosis and Pulmonary Arterial Hypertension
Authors: Lenna Stefania , Farina Alessandra G. , Martyanov Viktor , Christmann Romy B. , Wood Tammara A. , Farber Harrison W. , Scorza Raffaella , Whitfield Michael L. , Lafyatis Robert , Trojanowska Maria 
Published: February 2013

AbstractObjectivePulmonary arterial hypertension (PAH), a common complication of limited cutaneous systemic sclerosis (lcSSc), is associated with alterations of markers of inflammation and vascular damage in peripheral blood mononuclear cells (PBMCs). Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been implicated in autoimmune and inflammatory diseases. The goal of this study was to assess whether markers of ER stress and the UPR are present in PBMCs from lcSSc patients with PAH.MethodsPBMCs were purified from 36 healthy controls, 32 lcSSc patients with PAH, and 34 lcSSc patients without PAH. Gene expression in healthy control PBMCs stimulated with thapsigargin was analyzed by DNA microarray. Genes were validated by quantitative real‐time reverse transcription–polymerase chain reaction in PBMCs from healthy controls and lcSSc patients.ResultsSeveral ER stress/UPR genes, including BiP, activating transcription factor 4 (ATF‐4), ATF‐6, and a spliced form of X‐box binding protein 1, were up‐regulated in PBMCs from lcSSc patients, with the highest levels in patients with PAH. Thapsigargin up‐regulated heat‐shock proteins (HSPs) and interferon (IFN)–regulated genes in PBMCs from healthy controls. Selected HSP genes (particularly DnaJB1) and IFN‐related genes were also found at significantly elevated levels in PBMCs from lcSSc patients, while IFN regulatory factor 4 expression was significantly decreased. There was a positive correlation between DnaJB1 and severity of PAH (measured by pulmonary artery pressure) (r = 0.56, P < 0.05) and between ER stress markers and interleukin‐6 levels (r = 0.53, P < 0.0001) in PBMCs from lcSSc patients.ConclusionThis study demonstrates an association between select ER stress/UPR markers and lcSSc with PAH, suggesting that ER stress and the UPR may contribute to the altered function of circulating immune cells in lcSSc.
Fluorescence spectroscopic analysis on interaction of fleroxacin with pepsin
Authors: Lian Shuqin , Wang Guirong , Zhou Liping , Yang Dongzhi 
Published: February 2013

ABSTRACTThe interaction between fleroxacin (FLX) and pepsin was investigated by spectrofluorimetry. The effects of FLX on pepsin showed that the microenvironment of tryptophan residues and molecular conformation of pepsin were changed based on fluorescence quenching and synchronous fluorescence spectroscopy in combination with three‐dimensional fluorescence spectroscopy. Static quenching was suggested and it was proved that the fluorescence quenching of pepsin by FLX was related to the formation of a new complex and a non‐radiation energy transfer. The quenching constants KSV, binding constants K and binding sites n were calculated at different temperatures. The molecular interaction distance (r = 6.71) and energy transfer efficiency (E = 0.216) between pepsin and FLX were obtained according to the Forster mechanism of non‐radiation energy transfer. Hydrophobic and electrostatic interaction played a major role in FLX–pepsin association. In addition, the hydrophobic interaction and binding free energy were further tested by molecular modeling study. Copyright © 2013 John Wiley & Sons, Ltd.