bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life in patients treated with breast cancer surgery and adjuvant systemic therapy and/or adjuvant radiotherapy in Uruguay
Authors: Camejo Natalia , Amarillo Dahiana , Castillo Cecilia , Guerrina María , Savio Florencia , Carrasco Mariana , Strazzarino Noelia , Hernandez Ana Laura , Herrera Guadalupe , Krygier Gabriel 
Published: June 2024

ABSTRACT

Introduction:
Breast cancer (BC) and its treatment can impair patient quality of life (QoL), and those undergoing more aggressive treatments may be more severely impacted. Objective: Assess the level of perception of the QoL of patients treated for BC at the Hospital de Clínicas and the Departmental Hospital of Soriano.

Materials and Methods:
A questionnaire for cancer patients (EORTC, QLQ-C30) and one specific for BC (EORTC QLQ-BR23) were used.

Results:
A total of 158 patients who had completed chemotherapy treatment at least one year prior to the evaluation were enrolled. The average age was 61 years old.

QLQ-C30 Questionnaire:
The global QoL score (GQOL) was high: 70.9. Patients undergoing breast-conservation surgery (BCS) had better scores in physical and emotional functioning (p < 0.005) and presented less frequently with: pain, constipation, and financial difficulties (p < 0.005). Those undergoing sentinel lymph node biopsy (SLNB) had higher scores for GQOL and for physical, role, and social functioning scales (p < 0.001) and had less fatigue, pain, insomnia, and financial difficulties (p < 0.005).

Questionnaire QLQ-BR23:
Sexual functioning and sexual enjoyment scales were relatively low. Patients undergoing BCS had better scores on the functional scales: body image and future outlook; and fewer breast symptoms (p < 0.005). Those undergoing SLNB also had better scores on the functional scales for body image and future outlook future and presented less frequently with symptoms (p < 0.005).

Conclusion:
Uruguayan BC patients experience high values on the GQOL scale; those undergoing BCS and SLNB had better scores on most functional and problem/symptom scales. Patients undergoing BCS had better scores in physical and emotional functioning and presented less frequently with pain, constipation, and financial difficulties. With respect to the type of axillary surgery received, patients who underwent SLNB had higher scores on the GQOL scale and on the physical, role, and social functional scales. The implementation of intervention strategies aimed at improving the quality of life, and the physical and emotional care of patients is recommended.
Transcutaneous electrical acupoint stimulation for alleviating pain in patients with advanced pancreatic cancer
Authors: Tian Wei , Zhang Yun , Yu Bingjie , Jin Haiyan , Wang Wen , Yuan Ting , Yu Shulin , Lu Haiyan 
Published: June 2024

ABSTRACT

Introduction:
Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer-related deaths globally, with a five-year survival rate of only 5%.

Objectives:
Pancreatic ductal adenocarcinoma is often fatal because of the lack of specific early symptoms and effective early screening tools. Therefore, 80%–85% of patients are usually diagnosed in the advanced stages. This study aimed to investigate the analgesic effect of transcutaneous electrical acupoint stimulation in patients with advanced pancreatic cancer.

Methods:
Eighty patients with advanced pancreatic cancer were recruited from the Integrative Medicine Department of our hospital between June 2017 and October 2018 and randomly divided into the experimental group (n = 40) and the control group (n = 40). The experimental group received transcutaneous electrical acupoint stimulation combined with analgesic medication for 3 consecutive days, while the control group received only analgesic medication. The pain scores of the two groups before and after intervention were compared.

Results:
The mean pain severity score was significantly lower in the experimental group than in the control group on day 1 (P < 0.001), day 2 (P < 0.001), day 3 (P = 0.005), and day 4 (P = 0.043).

Conclusion:
Transcutaneous electrical acupoint stimulation therapy effectively alleviates the pain of patients with advanced pancreatic cancer with a high degree of safety and minimal adverse effects, and is worthy of clinical application.
Quantum dots in noninvasive imaging of oral squamous cell carcinomas: A scoping literature review
Authors: Shetty Bhagyashree , Chauhan Rashmi S. , Tirupathi Sunnypriyatham , Krishnapriya Nene , Patil Lalit , Rathi Nilesh 
Published: June 2024

ABSTRACT
The current scoping review’s objective was to outline existing applications, recent breakthroughs, and quantum dots’ applicability in imaging of oral squamous cell cancer. Quantum dots are nanometric semiconductor crystals with customizable optical characteristics and intense, stable fluorescence suited for bioimaging and labeling. We used the Preferred reporting items for systematic reviews and meta-analyses (PRISMA) recommendations for conducting our systematic search. An analysis of the properties and applications of quantum dots in noninvasive detection of oral squamous cell cancer is presented in this study, which comprehensively explores the available evidence. Following searches in the databases PubMed, Ovid SP, and Cochrane using the search terms quantum dots AND oral squamous cell cancer, 55 published publications were chosen for this review. The review identified a total of eight papers that met the criteria. In noninvasive detection of oral squamous cell carcinoma, quantum dots have the potential to offer an array of therapeutic and diagnostic applications. Furthermore, quantum dots emit near-infrared and visible light, which is advantageous in biological imaging since it reduces light dispersion and absorption of tissue. The future may see quantum dots become a popular noninvasive imaging technique for oral squamous cell cancer. The number of studies accessible is quite limited, and further research is required.
INSM1 expression in neuroendocrine tumors in a tertiary care hospital
Authors: Chandrasekaran Kundhavai , Sundaram Sandhya , Balasubramanian Subalakshmi 
Published: June 2024

ABSTRACT

Aim:
Neuroendocrine tumors are heterogenous group of neoplasms that includes benign and malignant tumors that originate from neuroendocrine or nonneuroendocrine organs. Insulinoma-associated protein 1 (INSM1) is a zinc finger transcription factor originally isolated from subtraction library of human insulinoma. The main aim was to study the INSM1 expression in a spectrum of neuroendocrine tumors and a limited spectrum of nonneuroendocrine tumors.

Materials and Methods:
A total of 100 cases of which 57 neuroendocrine neoplasms and 43 nonneuroendocrine neoplasms were included in the study. Immunohistochemistry (IHC) was done and expression patterns of INSM1 were analyzed. Pituitary adenoma, medullary carcinoma of thyroid, pheochromocytoma lung, gastrointestinal, and pancreatic neuroendocrine tumors were the neuroendocrine tumors that were included in the study. Papillary carcinoma of thyroid, gastrointestinal adenocarcinoma, lung adenocarcinoma, and squamous cell carcinoma were the nonneuroendocrine tumors that were included in the study. Depending upon the tissue availability, comparison of INSM1 with synaptophysin and chromogranin was also done in few neuroendocrine tumors.

Results:
All the 57 neuroendocrine tumors showed positive expression for INSM1 and all the nonneuroendocrine tumors were negative for INSM1. This study is statistically significant.

Conclusion:
Our study suggests that INSM1 is a diagnostic marker for neuroendocrine tumors with high degree of sensitivity and specificity. The study is significant and suggests that INSM1– IHC shows nuclear positivity in a spectrum of neuroendocrine tumors. Being a nuclear marker, interpretation is easy and more reliable than the cytoplasmic markers. INSM1 has a stronger positivity than synaptophysin and chromogranin in the present study especially for small cell carcinoma lung. Hence, INSM1 may be included in the routine panel for neuroendocrine tumors along with synaptophysin and chromogranin.
Case series of urachal adenocarcinoma: Imaging features
Authors: Sah Anjali , Triveni GS , Chandrashekhara SH 
Published: June 2024

ABSTRACT
Urachal adenocarcinoma is an unusual and aggressive form of bladder cancer that arises from urachus, a midline fibrous remnant of allantois. Experience with diagnosing them is limited and differentiating urachal adenocarcinoma from other urachal pathologies like infected urachal cysts may be difficult at times. Differentials of urachal anomalies can be narrowed down by proper assessment of patient demographics, clinical details, lesion morphology, and imaging findings. With this case series of five patients of urachal adenocarcinoma, we have tried describing their clinical manifestation and imaging appearances.
A prospective study on the effect of tumor shrinkage on exit fluence gamma pass rate in high precision radiotherapy and influence of phantom setup error in patient-specific quality assurance
Authors: Tiwari Arnav , Das Saikat , Pandey Vindhyavasini P. , Kharade Vipin , Gupta Manish , Pasricha Rajesh 
Published: June 2024

ABSTRACT

Purpose:
Objective parameters for decision on adaptive radiotherapy depend on patient, tumor and treatment related factors. Present study reports geometric uncertainties occurring during high precision radiotherapy, beam fluence analysis and serial exit dose measurement as a patient-specific tool for adaptive radiotherapy.

Materials and Methods:
Serial exit dose fluence of 24 patients (at baseline and mid-treatment) undergoing IMRT/VMAT treatment were measured. Baseline and midtreatment exit dose evaluation was done using gafchromic films in predefined region of interest. Difference of volume of GTV at baseline (from simulation CT scan) and midtreatment CBCT scan was calculated (ΔGTV).

Results:
Population based systematic errors (mm) were 4.15, 2.26, 0.88 and random errors (mm) were 2.56, 3.69, and 2.03 in mediolateral (ML), craniocaudal (CC) and anteroposterior (AP) directions respectively. Gamma pass rate reduced with incremental shift. For a 5 mm shift, maximum deviation was found in anteroposterior axis (22.16 ± 7.50) and lowest in mediolateral axis (12.85 ± 4.95). On serial measurement of exit dose fluence, tumor shrinkage significantly influenced gamma pass rate. The mean gamma pass rate was significantly different between groups with 50% shrinkage of tumor volume (86.36 vs 96.24, P = 0.008, on multivariate analysis P = 0.026).

Conclusion:
Rapid fall of gamma pass rate was observed for set up error of ≥3 mm. Serial measurement of exit dose fluence by radiochromic film is a feasible method of exit dose comparison in IMRT/VMAT, where EPID dosimetry is not available with linear accelerator configuration. Our study suggests that there is a significant difference between gamma pass rates of baseline and mid treatment exit dose fluence with greater than 50% tumor shrinkage.
Predictors of residual disease after breast conservation surgery for ductal carcinoma in situ: A retrospective study
Authors: Patterson Ryan , Guest Mitchell , Shenouda Mariam , Pareek Vibhay , Galloway Katie , Bucher Oliver , Hebbard Pamela , Nashed Maged 
Published: June 2024

ABSTRACT

Background:
Breast-conserving therapy is the standard of care for ductal carcinoma in situ (DCIS). Debate on what constitutes a satisfactory margin persists. This study aimed to identify predictors of residual disease at re-excision.

Methods:
This is a population-based retrospective cohort study of women with DCIS who underwent a lumpectomy between 2007 and 2017 in Manitoba, with close (≤2 mm) or positive margins that led to re-excision.

Results:
The DCIS re-excision rate was 29.3% for 1001 patients. 63.2% of patients were found to have residual disease on re-excision. On univariable analysis, the size, margin status, number of positive margins, type of second surgery, and Van Nuys Prognostic Index score were associated with residual disease on re-excision. The size of DCIS and the number of positive margins remained statistically significant on multivariable analysis.

Conclusions:
Re-excision should be rationalized by considering the predictors of residual disease in conjunction with other factors.
Leiomyosarcoma of the bone: Unveiling the mystery of a spindly ossein
Authors: Shetty K Jayaprakash , Kishan Prasad HL , Kotian Shravya , Joshi Divya , Mathias Lawrence , Bhat Shubha 
Published: June 2024

ABSTRACT
Leiomyosarcoma (LMS) represents one of the most common soft tissue sarcomas, involving various anatomical sites like the retroperitoneum, genitourinary tract, and extremities. LMS of the bone is extremely rare, with a 0.7% incidence of all primary malignant bone tumors. They are histologically identical to the leiomyosarcomas of other sites but pose a diagnostic dilemma due to their rarity and varied presentation when it manifests as a bony lesion.
Imatinib in c-KIT-mutated metastatic solid tumors: A multicenter trial of Korean Cancer Study Group (UN18-05 Trial)
Authors: Kim Hye Ryeon , Lee Su Jin , Ahn Mi Sun , Kim Jeong Eun , Kang Myoung Joo , Hong Jung Yong , Lee Jeeyun , Kim Seung Tae 
Published: June 2024

ABSTRACT

Introduction:
We conducted an open-label, single-arm, multi-center phase II trial to evaluate the efficacy and safety of imatinib chemotherapy-refractory or metastatic solid tumor patients with c-KIT mutations and/or amplification.

Methods:

c-KIT mutations and amplification were detected using NGS. Imatinib (400 mg daily) was administered continuously in 28-day cycles until disease progression, unacceptable adverse events, or death by any cause. The primary endpoint was the objective response rate (ORR).

Result:
In total, 18 patients were enrolled on this trial. The most common tumor type was melanoma (n = 15, 83.3%), followed by ovarian cancer, breast cancer, and metastasis of unknown origin (MUO) (each n = 1, 5.5%). The total number of evaluable patients was 17, of which one patient had a complete response, six patients had partial response, and two patients had stable disease. The overall response rate (ORR) of 41.2% (95% CI 17.80–64.60) and a disease control rate of 52.9% (95% CI 29.17–76.63). The median progression-free survival was 2.2 months (95% CI 1.29–3.20), and median overall survival was 9.1 months (95% CI 2.10–16.11). The most common adverse events were edema (31.3%), anorexia (25.0%), nausea (18.8%), and skin rash (18.8%).

Conclusion:
Imatinib demonstrated modest anti-tumor activity and a manageable safety profile in chemotherapy-refractory solid tumors with c-KIT mutation, especially in melanoma patients.
Colorimetric Evaluation of Various Orthodontic Thermoformed Retainers Exposed to Different Staining Agents and Cleaning Techniques
Authors: Singh Swati , Jain Ravindra Kumar 
Published: June 2024

Abstract

Aims:
The aim of this in vitro study was to evaluate the color changes in the retainers by different manufacturers (Essix ACE, Forestadent, Leone, and Bioart) after exposure to various beverage solutions (coke, tea, coffee, and artificial saliva) and also to assess the stain removal potential of different cleansing agents [listerine (L) and retainer brite (RB)].

Materials and Methods:
A total of 320 specimens (80 samples in each group) of thermoformed retainers from four different manufacturers were tested. All retainers were thermoformed and were immersed in different beverages (black tea, coffee, and cola) and artificial saliva as a control group for 7 and 14 days. These were then cleaned by either L or RB crystals. The color changes (ΔE) in several retainers were assessed following a 7-day exposure (T1–T0), a 14-day exposure (T2–T0), and following cleaning (T3–T1 and T3–T2). The CIELAB color space approach was utilized to obtain the ΔE measurements. To statistically evaluate the data, t test, analysis of variance, Tukey’s range test, and Levene’s test were employed.

Results:
On intragroup comparison, all groups were stained by tea with significant differences at 7 and 14 days (P < 0.05). Significant differences in color change after cleaning by L at the 7-day interval (P < 0.05) were noted in group A for immersion in cola. No significant difference was noted for groups B and C (P > 0.05). Significant differences in color change after cleaning with RB for tea stains in group D (P < 0.05) were noted. Significant intergroup differences in staining were noted for tea at 7- and 14-day intervals (P < 0.05) with maximum staining in group D. For coffee, significant intergroup differences were noted with maximum staining in group A (P < 0.05) at both 7- and 14-day intervals. Significant intergroup differences in cleaning were noted at the 12- h interval in group A for tea stains by RB (P < 0.05) and cola stains by L (P < 0.05).

Conclusions:
Tea exhibited the greatest staining potential among all staining agents at 7-and 14-day intervals for Forestadent, Leone, and Bioart retainers, while coffee stained Essix ACE retainers the most. Among the four different retainer brands, Bioart exhibited the least staining with the various staining agents at 7- and 14-day intervals. RB eliminated tea stains better, whereas cola and coffee stains were better removed by L.
Assessment of Enamel Surface Using Scanning Electron Microscope After Debonding Conventional and Self-Ligating Metal and Ceramic Brackets: An In Vitro Study
Authors: Lishna Karalikkattil T , Shaloob Muhamed , Antony Vincy , Roshan Gazanafer , Parayaruthottam Prathapan , Mohammed Nayaz VP , Raheesh Muhammed 
Published: June 2024

Abstract

Aims:
Minimal enamel loss during bonding and debonding operations is ideal for preserving the enamel surface in fixed orthodontic treatment. This study aimed to assess the enamel surface after debonding conventional and self-ligating metal and ceramic brackets and compare their enamel damage index (EDI) and adhesive remnant index (ARI) using scanning electron microscopy (SEM).

Materials and Methods:
Thirty-two maxillary first premolar teeth were divided into four equal groups of eight teeth each. According to the type of brackets used, the teeth were set on acrylic blocks that were color-coded: Conventional metal brackets (ORMCO MINI 2000), Self-ligating metal brackets (ORMCO DAMON Q), conventional ceramic brackets (ORMCO SYMETRI CLEAR), and self-ligating Ceramic brackets (ORMCO DAMON CLEAR). After debonding was done using a straight debonding plier, the tooth surfaces were examined by SEM. The ARI and EDI were then evaluated. The Kruskal–Wallis test was used in inferential statistics to determine differences between the groups. The association between the ARI and the EDI was determined using the Pearson correlation test.

Results:
The ARI revealed lower values for teeth bonded with traditional ceramic brackets, along with higher scores in the EDI. This suggests that the enamel-resin interface was the primary site of bond failure, potentially leading to iatrogenic tooth surface damage from ceramic bracket debonding. Conversely, self-ligating stainless-steel brackets had the lowest EDI scores and higher ARI values, suggesting that the resin-bracket interface was the primary site of bond failure. Additionally, this group showed minimal to no enamel damage, with only a few enamel cracks observed.

Conclusion:
Self-ligating metal brackets showed the highest ARI scores and lowest EDI scores, whereas conventional ceramic brackets presented with lowest ARI scores and highest EDI scores. The enamel surfaces attached with ceramic brackets showed greater enamel cracks upon SEM analysis.
Triple Endobutton with Coracoacromial Ligament Transfer: A Modified Technique for Fixation of Acromioclavicular Joint Dislocation
Authors: Kesari Vikas , Prakash Jatin , Garg Jyoti , Jalan Divesh , Maggo Karan , Bhatia Naval 
Published: June 2024

Abstract

Introduction:
The study explores a novel technique for the fixation of acromioclavicular joint (ACJ) dislocation utilizing triple Endobutton and coracoacromial ligament (CAL) transfer. ACJ dislocations are common injuries that can lead to significant functional impairment and pain. Current treatment options often fall short of providing long-term stability and functional outcomes. Therefore, the development of new techniques is imperative to enhance patient outcomes.

Materials and Methods:
A prospective analysis was conducted on a cohort of patients with ACJ dislocation who were treated using the triple Endobutton and CAL transfer techniques. In this procedure, the lateral end of the clavicle, the coracoid, and the CAL were exposed. Two tunnels were drilled in the lateral clavicle and one in the coracoid. An Endobutton loaded with No. 2 FiberWire was passed under the coracoid and the medial clavicle tunnel in a retrograde manner. ACJ was then reduced and the No. 2 FiberWire was tied over the Endobutton on the clavicle. CAL was then passed through the lateral clavicle tunnel and tied over the Endobutton. Patients were evaluated based on clinical, radiological, and patient-reported outcomes.

Results:
In this study, 38 patients underwent ACJ dislocation repair using the triple Endobutton and CAL transfer technique. The patients’ ages ranged from 22 to 48 years, with a mean age of 39.4 years. The majority of patients was males (24) and had right-sided injuries (21). Dislocations were predominantly grade V (16 cases). Postoperative outcomes showed significant improvements in pain levels, functional scores, and joint alignment. The average Visual Analog Scale score decreased from 6.24 to 0.62, Constant Shoulder score improved from 29.5 to 88.3, and disability of the arm, shoulder, and hand scores decreased from 21.79 to 1.33. Radiographic evaluation demonstrated satisfactory joint alignment with no significant differences between right and left CC distances. No loss of reduction or major complications were observed, although two cases of superficial skin infections were treated successfully.

Conclusion:
The triple Endobutton and CAL transfer technique represents a satisfactory technique in the fixation of ACJ dislocation.
Arthroscopic Rotator Cuff Restoration Using Sironix Suture Anchor: A Retrospective Observational Study
Authors: Shah Krunal , Manwani Ruchita , Moharana Ashok Kumar , Angrish Sachin , Deepak T. S. 
Published: June 2024

AbstractPurpose:The most effective approach to treat individuals with rotator cuff tears (RCTs) remains uncertain, but operative treatment, especially arthroscopic surgery with various suture anchors, is becoming more popular. The purpose of this study was to assess the functional outcomes in patients who underwent arthroscopic RCTs restoration using Sironix suture anchors.Materials and Methods:Eighty patients (36 males and 44 females) who had arthroscopic rotator cuff restoration using Sironix suture anchors were included. Postoperatively, patients were followed up and functional outcomes were evaluated using the American Shoulder and Elbow Surgeons Standardization Shoulder Assessment (ASES), level of activity using the Simple Shoulder Test (SST) questionnaire, Quality of life using the Shoulder Pain and Disability Index (SPADI) scale, and Single Assessment Numerical Evaluation (SANE) score on a scale of 0–100. Adverse events were recorded post-RCTs restoration.Results:The functional outcomes were presented as the mean (standard deviation [SD]) values of total ASES, SPADI, and SST scores, which were observed to be 92.6 (05.28), 01.6 (02.46), and 90.3 (14.22), respectively. The SANE mean (SD) values of the operated shoulder and the opposite shoulder were 91.8 (10.22) and 97.3 (5.68), respectively, with aP= 0.0001. No serious adverse events were reported and none of the subjects discontinued the study.Conclusions:The current study demonstrated that the functional outcomes were quite satisfactory, with good results. Therefore, Sironix shoulder implants (CEPTRE®Knotted UHMWPE Suture PEEK Anchor and CEPTRE®Knotted UHMWPE Suture Titanium Anchor) were considered safe and effective in rotator cuff restoration.