bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volumetric alterations in the nucleus accumbens and caudate nucleus in bulimia nervosa: A structural magnetic resonance imaging study
Authors: Coutinho Joana , Ramos Ana Filipa , Maia Liliana , Castro Liliana , Conceição Eva , Geliebter Allan , Machado Paulo P.P. , Gonçalves Óscar , Sampaio Adriana 
Published: March 2014

ABSTRACTObjectiveBulimia nervosa (BN) is an eating disorder characterized by recurrent episodes of binge eating and inappropriate compensatory behaviors (such as purging, fasting, or excessive exercise) to prevent weight gain. BN has been associated with deficits in inhibitory control processes. The basal ganglia specifically, the nucleus accumbens (NAc) and the caudate nucleus (CN) are part of the frontostriatal circuits involved in inhibitory control. The main goal of this study was to investigate the presence of morphological alterations in the NAc and the CN in a sample of patients diagnosed with BN.MethodForty‐one female participants, 21 diagnosed with BN and 20 healthy matched controls (HC), underwent a structural magnetic resonance imaging (MRI) acquisition and clinical assessment. The NAc and the CN were manually segmented using the software Slicer 3D.ResultsThe results reveal a significant volumetric decrease in the CN and a preserved NAc volume in BN compared to the control group.DiscussionThese findings suggest a contributory role of the caudate nucleus part of the dorsal striatum in the psychopathology of BN. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:206–214)
Long‐term effectiveness of the combined minute ventilation and patient activity sensors as predictor of heart failure events in patients treated with cardiac resynchronization therapy: Results of the Clinical Evaluation of the Physiological Diagnosis Function in the PARADYM CRT device Trial (CLEPSYDRA) study
Authors: Auricchio Angelo , Gold Michael R. , Brugada Josep , Nölker G. , Arunasalam Siva , Leclercq Christophe , Defaye Pascal , Calò Leonardo , Baumann Oliver , Leyva Francisco 
Published: March 2014

AimsMonitoring early signs of clinical deterioration could allow physicians to adjust medical treatment for patients at risk of acute heart failure decompensation. To date, several strategies using different surrogate measures of clinical status emerged, but none has yet been proven to predict clinical events. We hypothesized that the Physiological Diagnostic feature, which combines data from minute ventilation and physical activity sensors, predicts heart failure events in patients implanted with cardiac resynchronization therapy with defibrillation (CRT‐D) devices.Methods and resultsThe Clinical Evaluation of the Physiological Diagnostic feature in the PARADYM CRT device (CLEPSYDRA) trial is a multicentre, prospective, non‐randomized, double‐blind study comprising 521 CRT‐D patients with heart failure [67.4 ± 10.1 years (mean ± SD), 82% male, New York Heart Association class III/IV 85.0%/6.7%, QRS 155.3 ± 26.6 ms, left ventricular ejection fraction 25.7 ± 7.7%]. The objective of the study was the sensitivity and false positive rate of the Physiological Diagnostic algorithm to predict heart failure events within the following month. After a mean follow‐up of 17.0 ± 8.7 months, 130 (25.6%) patients experienced a heart failure event. The sensitivity of the algorithm to predict an event was 34% and the false positive rate was 2.4 per patient‐year.ConclusionThirty‐four per cent of heart failure events occurring within a month were predicted by the Physiological Diagnostic algorithm, and 2.4 alerts per patient per year were not followed by an heart failure event within the subsequent month.
Photofunctional Conductors Based on TTF‐BODIPY Dyads Bearing p‐Phenylene and p‐Phenylenevinylene Spacers
Authors: Tsujimoto Keijiro , Ogasawara Reiko , Nakagawa Takahiro , Fujiwara Hideki 
Published: March 2014

AbstractThis paper describes the syntheses, crystal structure analyses and physical properties of new D–A dyads containing tetrathiafulvalene (TTF) and 4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene (BODIPY) moieties linked by a p‐phenylene or p‐phenylenevinylene spacer for the development of photoresponsive organic conducting materials that can show photofunctionality in the visible region. The absorption spectra of the synthesized dyads recorded in CHCl3 show strong absorptions at 505 nm originating from the BODIPY moiety and weak charge‐transfer absorptions at around 550 nm. The fluorescence corresponding to the BODIPY moiety was suppressed to less than half in all the dyads, which suggests the formation of photoinduced charge‐transfer states. All the thin‐film samples of the dyads spin‐coated onto ITO‐coated glass substrates exhibited electric current generation that are related to the absorption spectra of the thin films. In the crystalline samples of three dyads, the TTF moieties formed 1D conducting columns through the dimerization of the TTF moieties and relatively strong side‐by‐side interactions between neighbouring stacking columns. All the neutral crystals exhibited photoinduced conductivity along the stacking direction of the TTF moieties and the crystal with the weakest dimerization and the strongest side‐by‐side interaction showed the greatest photoconductivity of the three crystals. The PF6 salt of the dyad with a p‐phenylene spacer and a 2:1 stoichiometry of the dyad and anion exhibited semi‐conducting behaviour with a conductivity of 3.0 × 10–4 S cm–1 at room temperature and an activation energy of 0.18 eV, probably because this crystal has a half‐filled Mott insulating band structure that originates from strongly dimerized intermolecular interactions. Upon photoirradiation, this salt showed a slight enhancement of conductivity.
Evaluation of Large‐Scale Hydrogen Storage Systems in the German Energy Sector
Authors: Michaelis J. , Genoese F. , Wietschel M. 
Published: March 2014

AbstractThe increasing share of renewable energies in the German energy sector is changing the present generation structure and requires the usage of more flexible technologies. Storage systems are one option to balance fluctuating electricity generation and demand. But due to the high investments required, all storage technologies have difficulties meeting the challenge of economic feasibility. However, chemical long‐term storage technologies that use a gaseous medium as the energy carrier have the advantage of being a versatile storage medium that can be sold on different markets. This paper shows that serving both the electricity and fuel markets has positive impacts on the profitability of hydrogen storage systems. Under favorable conditions, which are characterized by high shares of renewable energies and high prices for energy carriers, a positive economic result is possible.
Brain systems mediating voice identity processing in blind humans
Authors: Hölig Cordula , Föcker Julia , Best Anna , Röder Brigitte , Büchel Christian 
Published: March 2014

AbstractBlind people rely more on vocal cues when they recognize a person's identity than sighted people. Indeed, a number of studies have reported better voice recognition skills in blind than in sighted adults. The present functional magnetic resonance imaging study investigated changes in the functional organization of neural systems involved in voice identity processing following congenital blindness. A group of congenitally blind individuals and matched sighted control participants were tested in a priming paradigm, in which two voice stimuli (S1, S2) were subsequently presented. The prime (S1) and the target (S2) were either from the same speaker (person‐congruent voices) or from two different speakers (person‐incongruent voices). Participants had to classify the S2 as either a old or a young person. Person‐incongruent voices (S2) compared with person‐congruent voices elicited an increased activation in the right anterior fusiform gyrus in congenitally blind individuals but not in matched sighted control participants. In contrast, only matched sighted controls showed a higher activation in response to person‐incongruent compared with person‐congruent voices (S2) in the right posterior superior temporal sulcus. These results provide evidence for crossmodal plastic changes of the person identification system in the brain after visual deprivation. Hum Brain Mapp 35:4607–4619, 2014. © 2014 Wiley Periodicals, Inc.
Chronic alcohol consumption and its effect on nodes of frontocerebellar and limbic circuitry: Comparison of effects in France and the United States
Authors: Le Berre Anne‐Pascale , Pitel Anne‐Lise , Chanraud Sandra , Beaunieux Hélène , Eustache Francis , Martinot Jean‐Luc , Reynaud Michel , Martelli Catherine , Rohlfing Torsten , Sullivan Edith V. , Pfefferbaum Adolf 
Published: March 2014

AbstractAlcohol use disorders present a significant public health problem in France and the United States (U.S.), but whether the untoward effect of alcohol on the brain results in similar damage in both countries remains unknown. Accordingly, we conducted a retrospective collaborative investigation between two French sites (Caen and Orsay) and a U.S. laboratory (SRI/Stanford University) with T1‐weighted, structural MRI data collected on a common imaging platform (1.5T, General Electric) on 288 normal controls (NC), 165 uncomplicated alcoholics (ALC), and 26 patients with alcoholic Korsakoff's syndrome (KS) diagnosed at all sites with a common interview instrument. Data from the two countries were pooled, then preprocessed and analyzed together at the U.S. site using atlas‐based parcellation. National differences indicated that thalamic volumes were smaller in ALC in France than the U.S. despite similar alcohol consumption levels in both countries. By contrast, volumes of the hippocampus, amygdala, and cerebellar vermis were smaller in KS in the U.S. than France. Estimated amount of alcohol consumed over a lifetime, duration of alcoholism, and length of sobriety were significant predictors of selective regional brain volumes in France and in the U.S. The common analysis of MRI data enabled identification of discrepancies in brain volume deficits in France and the U.S. that may reflect fundamental differences in the consequences of alcoholism on brain structure between the two countries, possibly related to genetic or environmental differences.Hum Brain Mapp 35:4635–4653, 2014. ©2014 Wiley Periodicals, Inc.
Neonatal atlas construction using sparse representation
Authors: Shi Feng , Wang Li , Wu Guorong , Li Gang , Gilmore John H. , Lin Weili , Shen Dinggang 
Published: March 2014

AbstractAtlas construction generally includes first an image registration step to normalize all images into a common space and then an atlas building step to fuse the information from all the aligned images. Although numerous atlas construction studies have been performed to improve the accuracy of the image registration step, unweighted or simply weighted average is often used in the atlas building step. In this article, we propose a novel patch‐based sparse representation method for atlas construction after all images have been registered into the common space. By taking advantage of local sparse representation, more anatomical details can be recovered in the built atlas. To make the anatomical structures spatially smooth in the atlas, the anatomical feature constraints on group structure of representations and also the overlapping of neighboring patches are imposed to ensure the anatomical consistency between neighboring patches. The proposed method has been applied to 73 neonatal MR images with poor spatial resolution and low tissue contrast, for constructing a neonatal brain atlas with sharp anatomical details. Experimental results demonstrate that the proposed method can significantly enhance the quality of the constructed atlas by discovering more anatomical details especially in the highly convoluted cortical regions. The resulting atlas demonstrates superior performance of our atlas when applied to spatially normalizing three different neonatal datasets, compared with other start‐of‐the‐art neonatal brain atlases.Hum Brain Mapp 35:4663–4677, 2014. ©2014 Wiley Periodicals, Inc.
Celecoxib: a new augmentation strategy for depressive mood episodes. A systematic review and meta‐analysis of randomized placebo‐controlled trials
Authors: Faridhosseini Farhad , Sadeghi Ramin , Farid Layla , Pourgholami Meysam 
Published: March 2014

ObjectiveThe aim of this research was to perform a systematic review to identify all randomized controlled trials (RCTs) evaluating the efficacy and safety of add‐on celecoxib for treatment of depressive mood episodes.MethodsFour electronic databases were systematically searched from their inception to 8 August 2013: PubMed, Cochrane Library (Cochrane Central Register of Controlled Trials), Scopus, and PsychINFO. Pooled difference in means of Hamilton Depression Rating Scale score, pooled odds ratio (OR) of treatment response, and pooled OR of remission were calculated as the main effect size. A random‐effects model was used to pool the data across studies.ResultsFive RCTs (four unipolar depression studies and one bipolar depression study) were included in the systematic review for qualitative data synthesis. Moreover, quantitative results of four RCTs (unipolar depression studies) were meta‐analyzed. The add‐on celecoxib group had a statistically significant decrease in means of the Hamilton Depression Rating Scale score at week 4 (pooled difference in means = 3.3, 95%CI [1.2–5.3],p = 0.002) and week 6 (pooled difference in means = 3.43, 95%CI [1.9–4.9],p < 0.0001). The add‐on celecoxib group also showed higher response (pooledOR = 6.6, 95%CI [2.5–17],p < 0.0001) and remission rates (pooledOR = 6.6, 95%CI [2.7–15.9],p < 0.0001) compared with the placebo group.ConclusionsCelecoxib can be considered as an effective add‐on treatment for unipolar depressive patients. Making conclusion regarding the efficacy and safety for longer duration warrants further studies with a larger sample size and longer follow‐up duration. Copyright © 2014 John Wiley & Sons, Ltd.
Fast differentiation of SIRS and sepsis from blood plasma of ICU patients using Raman spectroscopy
Authors: Neugebauer Ute , Trenkmann Sabine , Bocklitz Thomas , Schmerler Diana , Kiehntopf Michael , Popp Jürgen 
Published: March 2014

AbstractCurrently, there is no biomarker that can reliable distinguish between infectious and non‐infectious systemic inflammatory response syndrome (SIRS). However, such a biomarker would be of utmost importance for early identification and stratification of patients at risk to initiate timely and appropriate antibiotic treatment.Within this proof of principle study, the high potential of Raman spectroscopy for the fast differentiation of non‐infectious SIRS and sepsis is demonstrated. Blood plasma collected from 70 patients from the intensive care unit (31 patients with sepsis and 39 patients classified with SIRS without infection) was analyzed by means of Raman spectroscopy. A PCA‐LDA based classification model was trained with Raman spectra from test samples and yielded for sepsis a sensitivity of 1.0 and specificity of 0.82. These results have been confirmed with an independent dataset (prediction accuracy 80%). (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Sodium Tungstate: The First Application as Non‐oxidative Catalyst in Organic Synthesis
Authors: Khodabakhshi Saeed , Baghernejad Mojtaba 
Published: March 2014

AbstractA convenient synthesis of some pyranocoumarins was described via a one‐pot, three‐component reaction of 4‐hydroxyxoumarin, malononitrile and different aromatic aldehydes in the presence of sodium tungstate. This is the first application of sodium tungstate as non‐oxidative catalyst in organic reactions. Simple operation, use of readily available starting materials, good to excellent yields and short reaction times are the advantages of this method for the synthesis of these biologically important products.
Distinguishing between renal oncocytoma and chromophobe renal cell carcinoma using Raman molecular imaging
Authors: Stewart Shona , Kirschner Heather , Treado Patrick J. , Priore Ryan , Tretiakova Maria , Cohen Jeffrey K. 
Published: March 2014

Raman molecular imaging was evaluated as a tool for differentiating between kidney tumors which are sometimes confused using conventional histopathological methods.Renal oncocytoma and chromophobe renal cell carcinoma are two kidney tumors which occasionally possess overlapping histological features. There is no reliable alternative method to routine histologic examination for differentiating these neoplasms. However, a conclusive diagnosis is important, as renal oncocytoma is benign and chromophobe renal cell carcinoma has malignant potential, requiring different treatment options.In an investigation based on 88 patients, a partial least squares discriminant analysis model generated from Raman molecular images distinguished between chromophobe renal cell carcinoma and renal oncocytoma with a performance of 86% sensitivity and 81% specificity.These initial observations suggest that Raman molecular imaging may be applied not only to the differentiation of these kidney tumors but also to other applications for which conventional histological methods are not sufficient for a conclusive diagnosis. Copyright © 2014 John Wiley & Sons, Ltd.
Traumatic Brain Injury, PTSD, and Current Suicidal Ideation Among Iraq and Afghanistan U.S. Veterans
Authors: Wisco Blair E. , Marx Brian P. , Holowka Darren W. , Vasterling Jennifer J. , Han Sohyun C. , Chen May S. , Gradus Jaimie L. , Nock Matthew K. , Rosen Raymond C. , Keane Terence M. 
Published: March 2014

AbstractSuicide is a prevalent problem among veterans deployed to Iraq and Afghanistan. Traumatic brain injury (TBI) and psychiatric conditions, such as posttraumatic stress disorder (PTSD), are potentially important risk factors for suicide in this population, but the literature is limited by a dearth of research on female veterans and imprecise assessment of TBI and suicidal behavior. This study examined 824 male and 825 female U.S. veterans who were enrolled in the baseline assessment of the Veterans After‐Discharge Longitudinal Registry (Project VALOR), an observational registry of veterans with and without PTSD who deployed in support of the wars in Iraq and Afghanistan and were enrolled in the Veterans Affairs healthcare system. Results indicated that current depressive symptoms, PTSD, and history of prior TBI were all significantly associated with current suicidal ideation (Cohen's d = 0.91, Cramers’ Vs = .19 and .08, respectively). After adding a number of variables to the model, including psychiatric comorbidity, TBI history was associated with increased risk of current suicidal ideation among male veterans only (RR = 1.55). TBI is an important variable to consider in future research on suicide among veterans of the wars in Iraq and Afghanistan, particularly among male veterans.
46,XY disorder of sexual development resulting from a novel monoallelic mutation (p.Ser31Phe) in the steroid 5α‐reductase type‐2 (SRD5A2) gene
Authors: Chávez Bertha , Ramos Luis , Gómez Rita , Vilchis Felipe 
Published: March 2014

AbstractInactivating mutations of the 5α‐steroid reductase type‐2 (SRD5A2) gene result in a broad spectrum of masculinization defects, ranging from a male phenotype with hypospadias to a female phenotype with Wolffian structures. Molecular studies of the SRD5A2 revealed a new heterozygous gene variant within the coding region that results in phenotypic expression. A c.92C>T transition changing serine to phenylalanine at codon 31 of exon 1 (p.Ser31Phe) was identified in a patient with 46,XY disorder of sexual development who displayed glandular hypospadias with micropenis and bilateral cryptorchidism. The restoration of the p.Ser31Phe mutation by site‐directed mutagenesis and transient expression assays using cultured HEK‐293 cells showed that this novel substitution does not abolish but does deregulate the catalytic efficiency of the enzyme. Thus, the maximum velocity (Vmax) value was higher for the mutant enzyme (22.5 ± 6.9 nmol DHT mg protein−1 h−1) than for the wild‐type enzyme (9.8 ± 2.0 nmol DHT mg protein−1 h−1). Increased in vitro activity of the p.Ser31Phe mutant suggested an activating effect. This case provides evidence that heterozygous missense mutations in SRD5A2 may induce the abnormal development of male external genitalia.
Dynamics of radiation induced γH2AX foci in chromatin subcompartments of mouse pachytene spermatocytes and round spermatids
Authors: Singh Priti , Raman Mercy J. 
Published: March 2014

SUMMARYChromatin compaction is thought to influence the severity of radiation‐induced DNA damage. We assessed how chromatin state affects DNA double‐strand break repair within eu‐/heterochromatin domains in male germ cells by profiling the spatiotemporal dynamics of γ‐radiation‐induced γH2AX foci in confocal images of mouse pachytene spermatocytes and round spermatids (5 min to16 hr post‐irradiation, in vivo). In unirradiated cells, all DNA‐dense heterochromatin domains showed compaction by anti‐H3K9me3‐staining, except for peripheral areas. Following irradiation, this signal was lost within 5 min, but regained later (8–16 hr); these two events coincided with the appearance and loss of γH2AX foci, respectively. While euchromatin showed a large number of bright foci in both cell types, heterochromatin had few foci. In spermatids, a few small, faint foci appeared within chromocenters. Pachytene‐stage, on the other hand, lacked foci within heterochromatin, although a few were closely associated with the heterochromatin periphery. The number of euchromatin foci in spermatids showed a dose‐dependent enhancement following irradiation (0.5–4 Gy), although no significant increase was seen in the quantity of heterochromatin foci. While all foci in pachytene‐stage cells were resolved, spermatids showed large residual foci—especially from heterochromatin foci, which remained faint for up to 4 hr, then increased in size between 8–16 hr, expanding at the chromocenter periphery and eventually protruding into euchromatin at H3K9me3‐signal‐free areas. Thus, this study identified scant foci formation and poor repair within heterochromatin, with distinctly different dynamics in meiotic and post‐meiotic stages of spermatogenesis, and provides direct evidence for heterochromatin decompaction following DNA damage, which facilitates repair/repositioning of foci towards euchromatin domains. It is the first demonstration of spatiotemporal mobilization of double‐strand breaks with respect to chromatin subdomains in male germ cells. Mol. Reprod. Dev. 81: 484–496, 2014. © 2014 Wiley Periodicals, Inc.