bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancing Science and Economy in Space: An Empirical Assessment of the Experiments Conducted on the International Space Station National Laboratory
Authors: Wang Max 
Published: June 2024

Abstract

Expanding humanity beyond Earth entails scientific and socioeconomic advancements. Critical to this endeavor is to leverage space to improve terrestrial lives. Since its inception in 2005, the International Space Station United States National Laboratory has spearheaded in-space experimentation, transforming research into intellectual assets and applications on Earth. This paper evaluates the lab's scientific and economic impacts by linking ISS experimental records to scholarly publications and patent inventions. Our findings highlight several key points. First, the volume of experiments on the ISS has steadily increased, with notable contributions from commercial developers and investigators. Growth accelerated in 2012 following NASA's delegation of civilian research management to The Center for the Advancement of Science in Space. From the National Lab, 384 scholarly publications have emerged, predominantly post-2012 and from public sector investigations. However, this growth did not correspond to an increase in patent inventions. We then measured the impact of ISS research with paper and patent citations and applied regression analyses to estimate the variations associated with using the National Lab's facilities. Our results show that ISS papers and patents receive significantly higher citations than their terrestrial counterparts, even when individual scientist-level characteristics are fixed. The difference was disproportionately attributed to experiments developed by public entities, highlighting a fundamental distinction between private and public sciences. Overall, our findings suggest the gradual formation of an ecosystem around the ISS National Lab, which continuously advances scientific knowledge and economic development in space.
Effect of preoperative thoracic paravertebral nerve block using liposomal bupivacaine combined with drainage-tube patient-controlled analgesia on postoperative pain after thoracoscopic lobectomy: a prospective, multicentre, double-blind, randomized controlled study protocol
Authors: Sun Yongtao , Guo Na , Feng Yanyan , Zhang Min , Feng Hai , Sun Dongfeng , Li Yongmeng , Liu Mengjie , Guo Liang , Liu Kexuan , Zhu Ye , Ren Yiyan , Li Minghui , Chi Yongliang , Liu Zhongkai , Yuan Li , Lang Bao , Yang Zaiqi , Feng Nianhai , You Peijun , Zhang Wensheng , Su Diansan , Wu Jianbo 
Published: June 2024

Abstract

Backgroud: Thoracic paravertebral nerve block (TPVB) with liposomal bupivacaine (LB) is increasingly used for postoperative pain control in patients undergoing thoracic surgery, but relevant data are scarce, and there are few data on LB-TPVB combined with drainage tube patient-controlled analgesia (PCA). The aim of this study was to explore the effect of LB-TPVB combined with drainage-tube PCA on postoperative pain after thoracoscopic lobectomy.
Methods: This is a prospective, multicentre, double-blind, randomized controlled study. Participants will be randomly assigned to the standard bupivacaine (SB) group, SB + drainage-tube PCA (DTA) group, LB group, or LB + DTA group. The primary outcome is the 72-h mean numerical rating scale (NRS) pain score at rest. The target sample size is 228 patients, with 57 patients in each group.
Discussion: Our study hypothesizes that preoperative ultrasound-guided thoracic nerve block combined with drainage tube self-controlled analgesia is more effective in reducing postoperative pain following thoracoscopic lobe resection compared to thoracic nerve block alone. Additionally, liposomal bupivacaine was found to be more effective than standard bupivacaine in this context. These results will have implications for improving postoperative analgesia protocols for patients undergoing thoracoscopic lung surgery.
Trial registration: ClinicalTrials.gov, NCT06165991. Registered 29 November 2023, https://clinicaltrials.gov/study/NCT06165991.
Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome through transcriptiomic and proteomic analysis
Authors: Tee Andrew , Jones Rachel-Ann , Dunlop Elaine A. , Champion Jesse , Doubleday Peter , Claessens Tijs , Jalali Zahra , Seifan Sara , Perry Iain , Giles Peter , Harrison Oliver , Coull Barry , Houweling Arjan , Pause Arnim , Ballif Bryan 
Published: June 2024

Abstract

Birt-Hogg-Dubé (BHD) syndrome patients are uniquely susceptible to all renal tumour subtypes. The underlying mechanism of carcinogenesis is unclear. To study cancer development in BHD, we used human proximal kidney (HK2) cells and found that long-term folliculin (FLCN) knockdown was required to increase their tumorigenic potential, forming larger spheroids in non-adherent conditions. Transcriptomic and proteomic analysis uncovered links between FLCN, cell cycle control and the DNA damage response (DDR) machinery. HK2 cells lacking FLCN had an altered transcriptome profile with cell cycle control gene enrichment. G1/S cell cycle checkpoint signaling was compromised with heightened protein levels of cyclin D1 (CCND1) and hyperphosphorylation of retinoblastoma 1 (RB1). A FLCN interactome screen uncovered FLCN binding to DNA-dependent protein kinase (DNA-PK). This novel interaction was reversed in an irradiation-responsive manner. Knockdown of FLCN in HK2 cells caused a marked elevation of γH2AX and RB1 phosphorylation. Both CCND1 and RB1 phosphorylation remained raised during DNA damage, showing an association with defective cell cycle control with FLCN knockdown. Furthermore, Flcn-knockdown C. elegans were defective in cell cycle arrest by DNA damage. This work implicates that long-term FLCN loss and associated cell cycle defects in BHD patients could contribute to their increased risk of cancer.
Clinical Value of 1-Hour Delayed Gadolinium-DTPA Enhanced 3D T1 SPACE MR Images in Bell's Palsy
Authors: Han Jingzhe , Zhang Jinru , Deng Jinliang , Hao Ziyan , Xie Yanan , Kang Zhilei , Ren Hao , Chong Lining 
Published: June 2024

Abstract

Background: This study aims to examine the clinical value of 1-hour delayed gadolinium-DTPA-enhanced3D T1 SPACE MRI in Bell's palsy.
Methods: Patients diagnosed with Bell’s palsy between January 2021 and January 2023 were retrospectively selected. Both routine and 1-hour delayed contrast-enhanced MRI were analyzed retrospectively. Signal intensity ratios of the facial nerve to that of the adenohypophysis were calculated.
Results: The affected side's signal intensity ratio was higher than the unaffected side in the labyrinthian and geniculate ganglion segments on both routine and 1-hour delayed contrast-enhanced MRI. Additionally, the signal intensity ratio of the affected side labyrinthian and geniculate ganglion segments in 1-hour delayed contrast-enhance MRI was higher than routine contrast-enhance MRI.
Conclusions: A contrast-enhance MRI of Bell’s palsy is functional for detecting inflammatory lesions. Delayed contrast-enhance MRI can indicate a higher distinction in the affected facial nerve.
Artificial intelligence algorithm for preoperative prediction of FIGO stage in ovarian cancer based on clinical features integrated 18F-FDG PET/CT metabolic and radiomics features
Authors: Xu Shilin , Zhu Chengguang , Wu Meixuan , Gu Sijia , Wu Yongsong , Cheng Shanshan , Wang Chao , Zhang Yue , Zhang Weixia , Shen Wei , Yang Jiani , Yang Xiaokang , Wang Yu 
Published: June 2024

Abstract

Purpose
The FIGO stage is critical to guiding the treatments of OC. We tried to develop a model to predict the FIGO stage of OC through machine learning algorithms with patients’ pretreatment clinical, PET/CT metabolic, and radiomics features. (2) Methods: We enrolled OC patients who underwent PET/CT scans and divided them into two cohorts according to their FIGO stage. Then we manually delineated the VOI and calculated PET metabolic features. Other radiomics PET/CT features were extracted by Python. We developed 11 prediction models to predict stages based on four groups of features and conducted three experiments to verify the meaning of PET/CT features. We also redesigned experiments to demonstrate the stage prediction performance in OCCC and MCOC. (3) Results: 183 OC patients were enrolled in this study, and we obtained 137 features from four groups of data. The best model was an adaptive ensemble with an AUC value of 0.819. Our proposed models presented the best result of 0.808 in terms of AUC in OCCC and MCOC patients’ groups. (4) Conclusion: Through AI algorithms, the PET/CT metabolic and radiomics features combined with clinical features could improve the accuracy of staging prediction.
FAM134B attenuates apoptosis and EMT by inhibiting M1 macrophage polarization via PI3K/AKT pathway in rat lungs exposed to hyperoxia
Authors: Guo Hong , Zhao Xin , Yao Ying , Yu Kaihua , Chen Su-Heng , Li Yu-Lan 
Published: June 2024

Abstract

Oxygen therapy is widely used in pulmonary disease and critical care resuscitation. Unfortunately, prolonged exposure to high concentrations of oxygen may cause oxygen toxicity, leading to hyperoxia-induced acute lung injury (HALI). The injurious effects of lung following hyperoxia exposure are well established, and the effects include cell apoptosis and epithelial-to-mesenchymal transition (EMT). HALI responds to the inflammatory response induced by M1 macrophage polarization. Suppressing inflammation in macrophages protects against HALI. The PI3K/AKT pathway promotes cell survival in oxidative stress injury. Activation of Akt is a beneficial response protects against hyperoxic stress. FAM134B activates ER-phagy through binding to LC3B, ER fragments are degraded by ER-phagy, and ER homeostasis is maintained. We hypothesized that FAM134B may regulate macrophage polarization and inflammatory responses in hyperoxia-exposed rats via PI3K/AKT signaling pathway, thereby attenuating HALI. In this study, we clarified the role of FAM134B in lung tissues of hyperoxia-exposed rats and the effect of FAM134B on macrophage polarization. The expression of FAM134B and PI3K/AKT pathway were inhibited in rat lung tissues after hyperoxia exposure. We found that overexpression of FAM134B activated the PI3K/AKT pathway and reduced apoptosis and EMT in rat lung tissues after hyperoxia exposure. The PI3K/AKT pathway inhibitor, LY294002, reversed the protective effect of FAM134B in hyperoxia-exposed rats. Overexpression of FAM134B reduced the release of inflammatory factors (IL-1β, TNF-ɑ, IL-6) and polarization of M1 macrophages after hyperoxia exposure, and LY294002 reversed this effect. In conclusion, our study showed that FAM134B inhibits M1 macrophage polarization and inflammatory factor release via PI3K/AKT pathway and attenuates apoptosis and EMT in rat lung of hyperoxia-exposed FAM134B is a key target for HALI, which provides new ideas for the treatment of HALI.
Priorities of Nano Geometries in Suspension
Authors: Ahmad Imtiaz , Khan Hidayat Ullah , Jan Rahim 
Published: June 2024

Abstract

The yield collective effect that is generated by each member of the LC phase largely depends on a uniform dispersion of nanoparticles. Evaporation techniques have been used to complete several fluidic-assisted designs. We examine isolated arrays of heterogeneous nanoparticles, taking into account the free entropic volume effect, comb- and brush-effect, electrostatic, and Van der Waals effects. The crystallographic facets of suspended particles and capping agents on their surfaces determine the optimal arrangement of shapes and orientations. It has been discovered that self-assembling activities occur prior to substrate deposition in nanoparticles with both flat and curved geometries. The drying capillaries drive the structures to develop into more aligned and tightly packed, making it easier to bring all of their shapes in suspension together due to dominant attractive interactions. We investigated some noteworthy cases that shed light on the quantitative and significant factors that are involved in constructing well-organized systems.
Study on the Influence of Water Mist on Methane Explosion Characteristic Parameters in Variable-volume Space
Authors: Xu Yang , Li Yuanbing , Li Mian , Duan Yulong 
Published: June 2024

Abstract

A transparent and variable volume pipe was used to investigate the influence of water mist on different development stages of methane explosion flame. A sliding device was installed to enable the adjustment of the pipe space volume during the experiments. The results demonstrate that water mist has varying effects on different flame development stages, leading to changes in flame development structure and mechanisms. When water mist is sprayed before the flame passes through the nozzle, it will cause a turbulent transformation of the flame, accelerate the flame propagation speed, and increase overpressure in the combustion zone. Specifically, when water mist acts on the tip of a finger flame, it promotes the explosion with a significant increase in overpressure and flame velocity, resulting in the maximum overpressure that is 90.48% higher compared to the without water mist condition. When the flame front has already passed through the nozzle and the water mist is sprayed, the water mist will significantly improve the efficiency of flame quenching and reduce the maximum overpressure in the unburned area. Compared with the absence of water mist, the overpressure in the unburned zone decreases by 21.91% and the flame extinction time decreases by 28.07%.
The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2
Authors: Morales Pavel , Brown Abbigale J. , Sangare Lamba Omar , Yang Sheng , Kuihon Simon , Chen Baoyu , Saeij Jeroen 
Published: June 2024

Abstract

The obligate intracellular parasite Toxoplasma gondii causes life-threatening toxoplasmosis to immunocompromised individuals. The pathogenesis of Toxoplasma relies on its swift dissemination to the central nervous system through a ‘Trojan Horse’ mechanism using infected leukocytes as carriers. Previous work found TgWIP, a protein secreted from Toxoplasma, played a role in altering the actin cytoskeleton and promoting cell migration in infected dendritic cells (DCs). However, the mechanism behind these changes was unknown. Here, we report that TgWIP harbors two SH2-binding motifs that interact with tyrosine phosphatases Shp1 and Shp2, leading to phosphatase activation. DCs infected with Toxoplasma exhibited hypermigration, accompanying enhanced F-actin stress fibers and increased membrane protrusions such as filopodia and pseudopodia. By contrast, these phenotypes were abrogated in DCs infected with Toxoplasma expressing a mutant TgWIP lacking the SH2-binding motifs. We further demonstrated that the Rho-associated kinase (Rock) is involved in the induction of these phenotypes, in a TgWIP-Shp1/2 dependent manner. Collectively, the data uncover a molecular mechanism by which TgWIP modulates the migration dynamics of infected DCs in vitro.
Dynamic monitoring of pulmonary endometriosis based on HRCT
Authors: Ni Yunlong , Feng Xia , Zhou Yingying 
Published: June 2024

Abstract

Endometriosis (EMS) refers to the appearance, growth and infiltration of endometrial tissues (glands and stroma) in the uterine cavity covering the endometrium and other parts of the uterus, repeated bleeding, Rare pelvic and intraperitoneal endometriosis can invade various areas such as the pleura, lungs, groin, umbilical cord, diaphragm, sciatic nerve, external ear, scalp, etc.Thoracic endometriosis syndrome (TES) is a rare disorder characterized.It can be divided into pleural and pulmonary endometriosis (PEM)according to the site of the lesion.The pathogenesis of TES has not yet been clarified, and multiple hypotheses have been proposed to explain its pathogenesis and clinical manifestations.The abnormality of the immune system is one of the important factors that cause and promote the occurrence and development of EMS.We report a 32-year-old woman diagnosed at our hospital with PEM presented a clinical characteristic of intermittent cough and hemoptysis and a pathologic manifestation of a large amount of hemosiderin deposition and a small amount of fibrous tissue.The patient was treated with leuprolide combined with tibolone. The patient’s cough and hemoptysis improved significantly within a short period of time, and his lung lesions improved significantly.At the same time,he did not develop serious related complications.Our report suggests that Add-back therapy of the patient’s conditions is necessary in PEM patients with not accepted surgical treatment.Leuprolide combined with tibolone may be an induction therapy with safety and feasibility.However, more clinical trials are needed to validate the efficacy and safety of the therapeutic regimen.
Heading biomechanics in female football: A systematic scoping review
Authors: Cicchella Antonio , Liu QIngguang , Chen Shinting , Shen Yinhao 
Published: June 2024

Abstract

Heading is a key skill in soccer. Research on heading focused mostly on males and young players, but it has been rarely investigated in female soccer players. Play scenario, training level, anthropometrics, frequency and intensity of headings, and long-term outcomes, such as vigilance and neuro-cognitive condition, are of interest for injury prevention. This systematic review aims to survey available knowledge about heading biomechanics in female football players to identify possible weakness and issues for future research directions in the field. A structured literature search was performed in PubMed, Scopus, Web of Science, and Sport Discus. The selection criteria included the following: (i) studies that focused on head impact only in females in soccer; and (ii) studies that included mechanics of the heading in females and outcomes (acute or long terms). Research on heading in female soccer players is sparse, and drawing firm conclusion on the investigated aspects (effect of play position, occurence, cognitive impairment, influence of muscle strength, and player’s level) is difficult. Mild-intensity heading is not dangerous, helmet does not help, play state and player position influence heading, and high rotational velocities are achieved. Response to a long kick is more risky, and strenghtening of neck muscles helps prevent injuries. This work identifies new direction for research and a basis on ameliorating heading training and skills and developing an effective and safe heading technique. Initiatives to improve safety in women’s soccer and prevent injuries from heading are necessary to reduce the gap in the knowledge between men and women players.
Impact of Seeds Germination on the Physicochemical and Techno-Functional Properties of Lupin Flours and Isolates
Authors: Navarro-Vozmediano Paola , Bou Ricard , García-Pérez José V. , Dalmau Esperanza , Benedito José J. 
Published: June 2024

Abstract

Nowadays, lupin seeds have emerged as a novel and valuable source of proteins representing a sustainable alternative to current raw materials of plant-based proteins, such as soybean. In this regard, lupin demonstrates superior adaptation to the Mediterranean climate with improved tolerance to water stress. However, its suitability for human consumption is limited due to the presence of anti-nutritional and anti-technological factors, including alkaloids, polyphenols, tannins and lipids, which can have adverse nutritional consequences and/or impact on the purity and yield of protein extraction. In this study, the Lupinus luteus seeds were germinated for 1, 2, 3 and 6 d and the effect of germination on the anti-nutritional and anti-technological factors of flours and derived protein isolates was analyzed. Additionally, changes on techno-functional properties of lupin protein isolates were also studied. Results showed that prolonged germination decreased fat content whereas antioxidant activity, polyphenols, saponin, and alkaloid content of flours increased. However, alkaloids were completely removed during protein extraction. Furthermore, protein isolates derived from germinated seeds exhibited higher water and oil absorption capacities, as well as an improved foaming and emulsifying capabilities in comparison to isolates from non-germinated seeds. Nevertheless, prolonged germination periods were associated with diminished foam and emulsion stability. Therefore, germination of lupin seeds for no longer than 3 d should be recommended in order to minimize the levels of anti-nutritional and anti-technological factors, while enhancing techno-functional properties of the isolate.
Universal Full-Day Kindergarten and Maternal Labor Supply: A Life-Cycle Analysis
Authors: Erceg Ashley , Genadek Katie , West Kristine 
Published: June 2024

Abstract

We estimate the effect of state-level policies enacting universal free full-day kindergarten on mothers’ labor supply using a life-cycle analysis. Similar to previous research on childcare and labor supply, we find that free full-day kindergarten increases labor force participation rates for mothers whose youngest child is kindergarten-aged by 4.3 to 7.1 percentage points. We find that for mothers whose youngest child is an infant, labor force participation increases by 7.2 to 9.8 percentage points, and for women whose youngest child is 3 to 4 years old labor force participation increases by 5.9 to 7.9 percentage points. The fact that the policies impact the labor supply for mothers of younger-than-kindergarten-age children by even more than for mothers of kindergarten-aged children is important for understanding the full effect of subsidized childcare. This is consistent with a life-cycle model of labor supply where wages and prices in future periods impact mothers’ labor force attachment.
Assessing the Microbiological Spectrum of Dacryocystitis Patients at a Tertiary Eye Hospital: A Retrospective Study
Authors: Alshehri Amjad , Alwazae Manal , AlAbdulakadir Ghaliah , Altahan Faisal , AlThaqib Abdulrahman , Alsuliman Hamad , AlThaqib Rawan 
Published: June 2024

Abstract

Purpose: The purpose of this study is to determine the microbiological spectrum and the demographics of dacryocystitis patients.
Methods: A retrospective chart review on patients’ electronic medical records were utilized to collect data on patients who presented with dacryocystitis. A total of 97 patients were included and data were collected on the demographics, type of organisms, antibiotic sensitivity, response to antibiotics therapy, management, and complications.
Results: Gram-positive cultures predominated in all genders in both adult and pediatric age groups and accounted for 61.3% of the sample. In adults, Staphylococcus aureus was the leading gram-positive organism (25.7%) while Pseudomonas aeruginosa(7.9%) and Haemophilus influenzae (6.9%) were the most common gram-negative organisms. In pediatric cases, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus intermedius were equally prevalent and gram-negative infection was exclusively due to Haemophilus species (26%).
Conclusions: Comprehending the microbiologic spectrum and its trend is crucial for managing an infection and recommending suitable antibiotic therapy. Initial Empirical therapy for dacryocystitis cases is targeted toward the Gram-positive organisms due to its prevalence. As a result, we heartily advise conducting a local study from time to time to assess the trend in the microbiological spectrum and shift in epidemiology, along with the antimicrobial sensitivity.