bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of moderate chronic kidney disease with insufficient improvement of fractional flow reserve after stent implantation
Authors: Sakoda Kunihiro , Tanaka Nobuhiro , Hokama Yohei , Hoshino Kou , Murata Naotaka , Yamashita Jun , Yamashina Akira 
Published: October 2015

ObjectivesThis study aims to investigate the association of moderate chronic kidney disease (CKD) with fractional flow reserve (FFR) after stent implantation.BackgroundPatients with moderate CKD have a higher prevalence of severe and diffuse coronary artery disease, and have increased risk of cardiovascular events even after stent implantation. On the other hand, in some patients, FFR could not be sufficiently improved even after stent implantation. However, the association between these pathophysiological processes is unclear.Methods and ResultsA total of 102 patients with stable angina, in whom a stent was implanted for the left anterior descending coronary artery (LAD) lesion, were included. Patients with a severely decreased glomerular filtration rate (GFR; > CKD stage 4) were excluded. Patients were stratified into 3 groups: those with an estimated GFR (eGFR) ≥ 60 mL per min per 1.73 m2 (stage 0‐2), 45 to 59 mL per min per 1.73 m2 (stage 3a), and 30 to 44 mL per min per 1.73 m2 (stage 3b). FFR after stent implantation (post‐stent FFR) was significantly lower in the stage 3b group than in both the stage 0‐2 group and the stage 3a group (P < 0.01). Post‐stent FFR had a significant positive correlation with eGFR (r = 0.223, P = 0.024). Multivariate analysis demonstrated that eGFR was an independent predictor of post‐stent FFR.ConclusionsModerate CKD was independently associated with insufficient improvement of FFR after stent implantation. This can partly explain the poor prognosis of patients with CKD. © 2015 Wiley Periodicals, Inc.
Transcatheter aortic valve implantation: Watch out for the leak, irrespective of aortic valve disease type
Authors: Belardi Jorge A. , Albertal Mariano 
Published: October 2015

Key Points

Postprocedural aortic regurgitation (PAR) after transcatheter aortic valve implantation (TAVI) is associated with a worst clinical outcome.
The presence of chronic aortic regurgitation in TAVI candidates increases PAR risk but not overall survival.
Future valve prototypes will likely reduce the degree and frequency of this complication.
Alternative Hydrogen Source for Asymmetric Transfer Hydrogenation in the Reduction of Ketones
Authors: Wakeham Russell J. , Morris James A. , Williams Jonathan M. J. 
Published: October 2015

Abstractcis‐1,4‐Butenediol is shown to be a highly active hydrogen source for asymmetric transfer hydrogenation in the reduction of ketones. With the use of a ruthenium catalyst, cis‐1,4‐butenediol is isomerised and subsequently oxidised to a lactone as an irreversible step, which provides the driving force for the asymmetric reduction of ketones.
Bipolar Electrochemical Displacement: A New Phenomenon with Implications for Self‐Limiting Materials Patterning
Authors: Braun Trevor M. , Schwartz Daniel T. 
Published: October 2015

AbstractBipolar electrochemical displacement (BED) enables direct‐write electrodeposition on a conducting substrate that has no electrical connection. We demonstrate this phenomenon using nickel deposition coupled to the equal and opposite displacement of copper. The driving force for BED is the solution potential gradient generated by a specially configured rastering microjet electrochemical cell. BED is self‐limiting based on the quantity of metal available for displacement from the substrate. Finite‐element method simulations are used to show how the coupling between solution ohmic drop and charge transfer kinetics control bipolar efficiency and spatial segregation of the electrochemistry. Experiments and simulations show that the electrodeposition of nickel is largely dictated by the potential gradients in the microjet region, and largely unaffected by details of copper etching far from the microjet. Simple analytical scaling arguments explain most of the experimental trends.
Highly Lewis Acidic Arylboronate Esters Capable of Colorimetric Turn‐On Response
Authors: Oehlke Alexander , Auer Alexander A. , Schreiter Katja , Friebe Nadine , Spange Stefan 
Published: October 2015

AbstractA series of boronate‐π‐acceptor compounds containing different types of π bridges (1,4‐phenylen or thien‐2,5‐diyl or furan‐2,5‐diyl) that link the switchable boronate ester group with the efficient TCF acceptor group (TCF=2‐dicyanomethylen‐3‐cyano‐4,5,5‐trimethyl‐2,5‐dihydrofuran) has been synthesized. A TCF chromophore of this type undergoes transition to a donor‐π‐acceptor compound upon coordination of Lewis bases at the Lewis acidic boron center, which is accompanied by an enhanced intramolecular charge‐transfer interaction. The Lewis acid character has been investigated by spectroscopic measurements (UV/Vis, NMR spectroscopies) as well as DFT and ab initio‐based calculations. It is shown that the TCF acceptor group and thiophene or furan π‐bridges directly bound to the boron atom cooperatively increase the Lewis acidity. UV/Vis titration experiments confirm fluoride binding constants in the range of up to 108 M−1 in CH2Cl2. In addition to the strong boron fluoride binding motif, Lewis interactions also occur with weaker Lewis bases, such as pyridine or aliphatic alcohols. The unique combination of chromophoric and Lewis acidic properties is responsible for the intense colorimetric turn‐on response detectable after complex formation.
Highly Luminescent, Water‐Soluble Lanthanide Fluorobenzoates: Syntheses, Structures and Photophysics, Part I: Lanthanide Pentafluorobenzoates
Authors: Kalyakina Alena S. , Utochnikova Valentina V. , Bushmarinov Ivan S. , Ananyev Ivan V. , Eremenko Igor L. , Volz Daniel , Rönicke Franziska , Schepers Ute , Van Deun Rik , Trigub Alexander L. , Zubavichus Yan V. , Kuzmina Natalia P. , Bräse Stefan 
Published: October 2015

AbstractHighly luminescent, photostable, and soluble lanthanide pentafluorobenzoates have been synthesized and thoroughly characterized, with a focus on EuIII and TbIII complexes as visible emitters and NdIII, ErIII, and YbIII complexes as infrared emitters. Investigation of the crystal structures of the complexes in powder form and as single crystals by using X‐ray diffraction revealed five different structural types, including monomeric, dimeric, and polymeric. The local structure in different solutions was studied by using X‐ray absorption spectroscopy. The photoluminescence quantum yields (PLQYs) of terbium and europium complexes were 39 and 15 %, respectively; the latter value was increased almost twice by using the heterometallic complex [Tb0.5Eu0.5(pfb)3(H2O)] (Hpfb=pentafluorobenzoic acid). Due to the effectively utilized sensitization strategy (pfb)−→Tb→Eu, a pure europium luminescence with a PLQY of 29 % was achieved.
Efficient Rhodium‐Catalyzed Multicomponent Reaction for the Synthesis of Novel Propargylamines
Authors: Rubio‐Pérez Laura , Iglesias Manuel , Munárriz Julen , Polo Victor , Pérez‐Torrente Jesús J. , Oro Luis A. 
Published: October 2015

Abstract[{Rh(μ‐Cl)(H)2(IPr)}2] (IPr = 1,3‐bis‐(2,6‐diisopropylphenyl)imidazole‐2‐ylidene) was found to be an efficient catalyst for the synthesis of novel propargylamines by a one‐pot three‐component reaction between primary arylamines, aliphatic aldehydes, and triisopropylsilylacetylene. This methodology offers an efficient synthetic pathway for the preparation of secondary propargylamines derived from aliphatic aldehydes. The reactivity of [{Rh(μ‐Cl)(H)2(IPr)}2] with amines and aldehydes was studied, leading to the identification of complexes [RhCl(CO)IPr(MesNH2)] (MesNH2 = 2,4,6‐trimethylaniline) and [RhCl(CO)2IPr]. The latter shows a very low catalytic activity while the former brought about reaction rates similar to those obtained with [{Rh(μ‐Cl)(H)2(IPr)}2]. Besides, complex [RhCl(CO)IPr(MesNH2)] reacts with an excess of amine and aldehyde to give [RhCl(CO)IPr{MesNCHCH2CH(CH3)2}], which was postulated as the active species. A mechanism that clarifies the scarcely studied catalytic cycle of A3‐coupling reactions is proposed based on reactivity studies and DFT calculations.
A Luminescent Nitrogen‐Containing Polycyclic Aromatic Hydrocarbon Synthesized by Photocyclodehydrogenation with Unprecedented Regioselectivity
Authors: Gu Xinggui , Wang Hong , Roose Jesse , He Zikai , Zhou Yue , Yan Yongli , Cai Yuanjing , Shi Heping , Zhang Yilin , Sung Herman H. Y. , Lam Jacky W. Y. , Miao Qian , Zhao Yongsheng , Wong Kam Sing , Williams Ian D. , Tang Ben Zhong 
Published: October 2015

AbstractWe present a nitrogen‐containing polycyclic aromatic hydrocarbon (N‐PAH), namely 12‐methoxy‐9‐(4‐methoxyphenyl)‐5,8‐diphenyl‐4‐(pyridin‐4‐yl)pyreno[1,10,9‐h,i,j]isoquinoline (c‐TPE‐ON), which exhibits high quantum‐yield emission both in solution (blue) and in the solid state (yellow). This molecule was unexpectedly obtained by a three‐fold, highly regioselective photocyclodehydrogenation of a tetraphenylethylene‐derived AIEgen. Based on manifold approaches involving UV/Vis, photoluminescence, and NMR spectroscopy as well as HRMS, we propose a reasonable mechanism for the formation of the disk‐like N‐PAH that is supported by density functional theory calculations. In contrast to most PAHs that are commonly used, our system does not suffer from entire fluorescence quenching in the solid state due to the peripheral aromatic rings preventing π–π stacking interactions, as evidenced by single‐crystal X‐ray analysis. Moreover, its rod‐like microcrystals exhibit excellent optical waveguide properties. Hence, c‐TPE‐ON comprises a N‐PAH with unprecedented luminescent properties and as such is a promising candidate for fabricating organic optoelectronic devices. Our design and synthetic strategy might lead to a more general approach to the preparation of solution‐ and solid‐state luminescent PAHs.
Boosting Proton Conductivity in Highly Robust 3D Inorganic Cationic Extended Frameworks through Ion Exchange with Dihydrogen Phosphate Anions
Authors: Xiao Chengliang , Wang Yaxing , Chen Lanhua , Yin Xuemiao , Shu Jie , Sheng Daopeng , Chai Zhifang , Albrecht‐Schmitt Thomas E. , Wang Shuao 
Published: October 2015

AbstractThe limited long‐term hydrolytic stability of rapidly emerging 3D‐extended framework materials (MOFs, COFs, MOPs, etc.) is still one of major barriers for their practical applications as new solid‐state electrolytes in fuel cells. To obtain hydrolytically stable materials, two H2PO4−‐exchanged 3D inorganic cationic extended frameworks (CEFs) were successfully prepared by a facile anion‐exchange method. Both anion‐exchanged CEFs (YbO(OH)P and NDTBP) show significantly enhanced proton conductivity when compared with the original materials (YbO(OH)Cl and NDTB) with an increase of up to four orders‐of‐magnitude, reaching 2.36×10−3 and 1.96×10−2 S cm−1 at 98 % RH and 85 °C for YbO(OH)P and NDTBP, respectively. These values are comparable to the most efficient proton‐conducting MOFs. In addition, these two anion‐exchanged materials are stable in boiling water, which originates from the strong electrostatic interaction between the H2PO4− anion and the cationic host framework, showing a clear advance over all the acid‐impregnated materials (H2SO4@MIL‐101, H3PO4@MIL‐101, and H3PO4@Tp‐Azo) as practical solid‐state fuel‐cell electrolytes. This work offers a new general and efficient approach to functionalize 3D‐extended frameworks through an anion‐exchange process and achieves water‐stability with ultra‐high proton conductivity above 10−2 S cm−1.
ChemInform Abstract: Ba and Sr Binary Phosphides: Synthesis, Crystal Structures, and Bonding Analysis.
Authors: Dolyniuk Juli‐Anna , He Hua , Ivanov Alexander S. , Boldyrev Alexander I. , Bobev Svilen , Kovnir Kirill 
Published: October 2015

AbstractSingle crystals of SrP2 (I), BaP2 (II), Ba5P4 (III), and Ba4P2.67 (IV) are prepared from mixtures of the elements using excess Pb as a flux (alumina crucibles, 1223 K, 40 h).
ChemInform Abstract: Syntheses, Crystal Structures, Ion‐Exchange, and Photocatalytic Properties of Two Amine‐Directed Ge—Sb—S Compounds.
Authors: Zhang Bo , Feng Mei‐Ling , Cui Hong‐Hua , Du Cheng‐Feng , Qi Xing‐Hui , Shen Nan‐Nan , Huang Xiao‐Ying 
Published: October 2015

AbstractThe crystal structures of the new compounds (IV) and (V) are determined by single crystal XRD.
ChemInform Abstract: K2Ca4 [(UO2)(Si2O7)2]: A Uranyl Silicate with a One‐Dimensional Chain Structure.
Authors: Liu Chia‐Lin , Liu Hsin‐Kuan , Chang Wen‐Jung , Lii Kwang‐Hwa 
Published: October 2015

AbstractThe new title compound is hydrothermally synthesized from a mixture of Ca(OH)2, UO3, SiO2, KOH, and H2O in a molar ratio of K:Ca:U:Si = 75:1:1:4 (gold ampule, 1400 bar, 550 °C, 4 d; 45% yield).
ChemInform Abstract: Synthesis and Exploration of Electronically Modified (R)‐5,5‐Dimethyl‐(p‐CF3)3‐i‐PrPHOX in Palladium‐Catalyzed Enantio‐ and Diastereoselective Allylic Alkylation: A Practical Alternative to (R)‐(p‐CF3)3‐t‐BuPHOX.
Authors: Craig Robert A. II , Stoltz Brian M. 
Published: October 2015

AbstractIt is demonstrated, that the novel phosphinooxazoline derivative (PHX) is an efficient ligand for the enantioselective allylic alkylation of silyl enol ether (I) and the diastereoselective decarboxylative allylic alkylation of the β‐ketoester (IV).
ChemInform Abstract: Rhodium‐Catalyzed [3 + 2 + 2] and [2 + 2 + 2] Cycloadditions of Two Alkynes with Cyclopropylideneacetamides.
Authors: Yoshida Tomoka , Tajima Yuki , Kobayashi Masayuki , Masutomi Koji , Noguchi Keiichi , Tanaka Ken 
Published: October 2015

AbstractA cationic Rh(I)/(S)‐BINAP complex catalyzes the enantioselective [2+2+2]‐cycloaddition of terminal alkynes, acetylenedicarboxylates and cyclopropylideneacetamides to furnish spiro‐cyclohexadiene derivatives without cleavage of the cyclopropane ring.
ChemInform Abstract: Selective Pinacol Coupling on Regeneratable Supported Acids in Sole Water.
Authors: Sotto Nicolas , Billamboz Muriel , Chevrin‐Villette Carole , Len Christophe 
Published: October 2015

AbstractThe reductive pinacol type dimerization of aldehydes (I) and acetophenone (V) is achieved using zinc and amberlyst 15 as reagents in water as the solvent.
ChemInform Abstract: Rh(III)‐Catalyzed C—H Alkylation of 2‐Arylbenzothiazoles with α‐Diazo Esters.
Authors: Choi Miji , Park Jihye , Mishra Neeraj Kumar , Lee Seok‐Yong , Kim Jun Hyeong , Jeong Kyung Min , Lee Jeongmi , Jung Young Hoon , Kim In Su 
Published: October 2015

AbstractThe title process provides a wide variety of monoalkylated compounds as sole or main products.
ChemInform Abstract: A Convergent Radical Based Route to Trifluoromethyl Ketones and to α,β‐Unsaturated Trifluoromethyl Ketones.
Authors: Anthore Lucile , Zard Samir Z. 
Published: October 2015

AbstractStarting from vinyl sulfone (I) and various dithiocarbonates, trifluoromethyl ketones and their α,β‐unsaturated pendants become accessible via a radical based process.
ChemInform Abstract: Iron‐Catalyzed Oxidative Ugi‐Type Multicomponent Reaction Using (Arylmethyl)amines as Imine Precursors.
Authors: Dighe Shashikant U. , Kolle Shivalinga , Batra Sanjay 
Published: October 2015

AbstractThe title reaction represents the first example of an iron‐catalyzed Ugi‐type reaction using iminium species generated by oxidation of (arylmethyl)amines.
ChemInform Abstract: Synthesis of Various Lignans via the Rearrangements of 1,4‐Diarylbutane‐1,4‐diols.
Authors: Davidson Samuel J. , Barker David 
Published: October 2015

AbstractTreatment of 1,4‐diarylbutane‐1,4‐diols with Et3N and MesCl leads to the formation of 4,4‐diarylbutanals as the major products.
ChemInform Abstract: Synthesis of β‐Trifluoromethylated Ketones from Propargylic Alcohols by Visible Light Photoredox Catalysis.
Authors: Park Sehyun , Joo Jung Min , Cho Eun Jin 
Published: October 2015

AbstractTrifluoromethylation of propargylic alcohols in the presence of a photocatalyst followed by double‐bond migration/keto‐enol tautomerization provides access to β‐trifluoromethylketones.
ChemInform Abstract: Nickel‐Catalyzed Synthesis of Diarylsulfides and Sulfones via C—H Bond Functionalization of Arylamides.
Authors: Reddy Vutukuri Prakash , Qiu Renhua , Iwasaki Takanori , Kambe Nobuaki 
Published: October 2015

AbstractArylbenzamides equipped with a quinoline directing group are sulfenylated with various diaryldisulfides.
ChemInform Abstract: Synthesis of N‐Imidoyl and N‐Oxoimidoyl Sulfoximines from 1‐Alkynes, N‐Sulfonyl Azides, and Sulfoximines.
Authors: Choi Wonseok , Kim Jaeeun , Ryu Taekyu , Kim Ki‐Bbeum , Lee Phil Ho 
Published: October 2015

AbstractThe three‐component one‐pot syntheses are Cu‐catalyzed and proceed under air.
ChemInform Abstract: Chiral Phosphine—Silver(I) Complex Catalyzed Enantioselective Interrupted Feist—Benary Reaction with Ynones: The Aldol—Cycloisomerization Cascade.
Authors: Sinha Debarshi , Biswas Arnab , Singh Vinod K. 
Published: October 2015

AbstractA variety of dihydrofuran derivatives with exocyclic double bond is efficiently obtained with high enantioselectivity using a Ag‐catalyzed interrupted Feist—Benary reaction.
ChemInform Abstract: Synthesis of Dibenzofurans via C—H Activation of o‐Iodo Diaryl Ethers.
Authors: Panda Niranjan , Mattan Irshad , Nayak Dinesh Kumar 
Published: October 2015

AbstractIodo diaryl ethers are easily prepared by sequential iodination/etherification of deactivated phenols (phenols with electron‐donating or neutral groups do not work) using aryl iododiacetates.
ChemInform Abstract: Organocatalytic Asymmetric 1,6‐Addition/1,4‐Addition Sequence to 2,4‐Dienals for the Synthesis of Chiral Chromans.
Authors: Poulsen Pernille H. , Feu Karla Santos , Paz Bruno Matos , Jensen Frank , Joergensen Karl Anker 
Published: October 2015

AbstractA wide range of optically active chromans are highly regio‐ and stereoselectively obtained utilizing a novel asymmetric 1,6‐Friedel—Crafts/1,4‐oxa‐Michael cascade reaction of hydroxyarenes with 2,4‐dienals.
ChemInform Abstract: Base‐Promoted β‐C(sp3)—H Functionalization of Enaminones: An Approach to Polysubstituted Pyridines.
Authors: Shen Jinhai , Cai Dingding , Kuai Changsheng , Liu Yunqi , Wei Ming'e , Cheng Guolin , Cui Xiuling 
Published: October 2015

Abstract1‐Arylethylamines and 1,3‐diarylprop‐2‐ynones give 2,4,6‐triarylpyridines regioselectively under basic conditions using air as the oxidant.
ChemInform Abstract: Three‐Component Functionalized Dihydropyridine Synthesis via a Formal Inverse Electron‐Demand Hetero‐Diels—Alder Reaction.
Authors: Yan Xiaonan , Ling Fei , Zhang Yuchen , Ma Cheng 
Published: October 2015

AbstractThe reaction proceeds trough a formal inverse electron‐demand hetero‐Diels—Alder reaction of electron‐deficient 1‐azadienes with metalated ynamide intermediates arising from a Cu‐catalyzed azide—alkyne reaction.
ChemInform Abstract: Lewis Acid Catalyzed Condensation—Cyclization Cascade: Direct Synthesis of Di/Trifluoromethyl‐1,2,3,4‐tetrahydroquinazolines.
Authors: Prakash G. K. Surya , Papp Attila , Munoz Socrates B. , May Nathan , Jones John‐Paul , Haiges Ralf , Esteves Pierre Mothe , Mathew Thomas 
Published: October 2015

AbstractFluorinated quinazolines are conveniently obtained from simple difluoro/trifluoroacetaldehyde hemiacetals and aromatic amines using gallium triflate as safe and stable Lewis acid catalyst.
ChemInform Abstract: N‐Protected 1,2‐Oxazetidines as a Source of Electrophilic Oxygen: Straightforward Access to Benzomorpholines and Related Heterocycles by Using a Reactive Tether.
Authors: Javorskis Tomas , Sriubaite Simona , Bagdziunas Gintautas , Orentas Edvinas 
Published: October 2015

Abstract1,2‐Oxazetidine reacts with organometallic compounds to provide electrophilic oxygen with a nitrogen‐terminated two‐carbon‐atom tether.
ChemInform Abstract: Freestanding Ultrathin Metallic Nanosheets: Materials, Synthesis, and Applications
Authors: Ling Tao , Wang Jing‐Jing , Zhang Hao , Song Shu‐Tao , Zhou Yu‐Zhu , Zhao Jiong , Du Xi‐Wen 
Published: October 2015

AbstractReview: 36 refs.
ChemInform Abstract: Titanate and Titania Nanostructured Materials for Environmental and Energy Applications: A Review
Authors: Zhang Yanyan , Jiang Zhelong , Huang Jianying , Lim Linda Y. , Li Wenlong , Deng Jiyang , Gong Dangguo , Tang Yuxin , Lai Yuekun , Chen Zhong 
Published: October 2015

AbstractReview: 306 refs.
ChemInform Abstract: Recent Progress in the Use of Pd‐Catalyzed C—C Cross‐Coupling Reactions in the Synthesis of Pharmaceutical Compounds
Authors: Biajoli Andre F. P. , Schwalm Cristiane S. , Limberger Jones , Claudino Thiago S. , Monteiro Adriano L. 
Published: October 2015

AbstractReview: 77 refs.
Lernen über digitale Medien in der Chemielehrerausbildung
Authors: Krause Moritz , Eilks Ingo 
Published: October 2015

AbstractDieser Artikel beschreibt die systematische Weiterentwicklung einer Lehrveranstaltung zur Nutzung digitaler Medien im Chemieunterricht an der Universität Bremen. Nach dem Ansatz der Partizipativen Aktionsforschung für Innovationen in der Hochschullehre wurden die Lehrveranstaltung über drei Jahre zyklisch verändert und begleitend dazu ausgewählte Aspekte des Einflusses einer solchen Lehrveranstaltung auf die Lernenden untersucht. Fokus der Untersuchung war der Effekt der Lehrveranstaltung auf die Einstellungen und die Selbstwirksamkeitserwartung der Studierenden zu digitalen Medien im Allgemeinen und bezogen auf den Chemieunterricht. Die Struktur der Lehrveranstaltung wird vorgestellt, Erfahrungen und Ergebnisse werden diskutiert.
Rationale, Design, and Methodological Aspects of the BUDAPEST‐GLOBAL Study (Burden of Atherosclerotic Plaques Study in Twins—Genetic Loci and the Burden of Atherosclerotic Lesions)
Authors: Maurovich‐Horvat Pál , Tárnoki Dávid L. , Tárnoki Ádám D. , Horváth Tamás , Jermendy Ádám L. , Kolossváry Márton , Szilveszter Bálint , Voros Viktor , Kovács Attila , Molnár Andrea Á. , Littvay Levente , Lamb Hildo J. , Voros Szilard , Jermendy György , Merkely Béla 
Published: October 2015

ABSTRACTThe heritability of coronary atherosclerotic plaque burden, coronary geometry, and phenotypes associated with increased cardiometabolic risk are largely unknown. The primary aim of the Burden of Atherosclerotic Plaques Study in Twins—Genetic Loci and the Burden of Atherosclerotic Lesions (BUDAPEST‐GLOBAL) study is to evaluate the influence of genetic and environmental factors on the burden of coronary artery disease. By design this is a prospective, single‐center, classical twin study. In total, 202 twins (61 monozygotic pairs, 40 dizygotic same‐sex pairs) were enrolled from the Hungarian Twin Registry database. All twins underwent non–contrast‐enhanced computed tomography (CT) for the detection and quantification of coronary artery calcium and for the measurement of epicardial fat volumes. In addition, a single non–contrast‐enhanced image slice was acquired at the level of L3‐L4 to assess abdominal fat distribution. Coronary CT angiography was used for the detection and quantification of plaque, stenosis, and overall coronary artery disease burden. For the primary analysis, we will assess the presence and volume of atherosclerotic plaques. Furthermore, the 3‐dimensional coronary geometry will be assessed based on the coronary CT angiography datasets. Additional phenotypic analyses will include per‐patient epicardial and abdominal fat quantity measurements. Measurements obtained from monozygotic and dizygotic twin pairs will be compared to evaluate the genetic or environmental effects of the given phenotype. The BUDAPEST‐GLOBAL study provides a unique framework to shed some light on the genetic and environmental influences of cardiometabolic disorders.