bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trade-offs between stump-to-roadside lead time and harvesting cost, when using different number of operators in a harvester-forwarder system
Authors: Johansson Malin , Lundbäck Mikael , Lindroos Ola 
Published: July 2024

AbstractFor customer-oriented wood supply, buffering is required for flexibility to handle interactions in the wood procurement system. This includes balancing lead-time and operational cost by using stocks and production capacity as buffers. Despite the well-known challenge to balance the interactions between harvesting and forwarding in Nordic mechaniced CTL-operations, there has been limited research on how the machine groups can be staffed to enable flexibility and more focus on other measures to create flexibility. Therefore, this study explored trade-offs between wood lead-time and harvesting cost in the stump-to-roadside part of the wood supply chain by altering the numer of full-time working operators in the harvesting groups. This was done using discrete-event simulations implemented in Anylogic software. Input data included information about operational conditions in 1500 forest stands. The results revealed that the best balance was to have sufficient harvesting capacity to adjust wood lead times at the expense of increased harvesting costs. Of the tested options, the best balance was achieved when staffing a two-machine group with three operators, and thereby allocating 50% of the used work-shifts to regulating the field wood stock between the two machines. This resulted in the shortest lead times and the smallest harvesting cost increase. Compared to the option with no flexibility for stock adjustment (4 operators), the average lead-time could be reduced to one tenth at a cost increase of 3.4%. These findings have the potential to improve decisions of how harvesting groups are staffed to balance specific objectives of desired lead times and costs, which migh prove to be a valuable addition to the already used measures to manage wood flow.
Public health interventions to prevent children drowning: an updated systematic review
Authors: Crawford Gemma , D’Orazio Nicola , Gray Corie , Royce Brooklyn , Maher Tneale , Della Bona Malena , Leavy Justine E. 
Published: July 2024

Abstract
Aim
Injuries are a leading cause of death and disability for children and young people worldwide and a significant public health challenge. This updated review identifies and assesses public health interventions designed to prevent child drowning. It aimed to evaluate the global scope of literature and examine contributions made to the evidence since the last review was published.

Subject and methods
The review follows processes established in previous reviews and recommendations of the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Articles were peer-reviewed, published in English between 2011 and 2023 and described and evaluated child drowning primary prevention interventions. Fifteen databases were searched, and articles were managed in Endnote and Rayyan.AI. The MetaQAT framework was applied to quality appraisal.

Results
We included a final sample of n = 43 studies. Most studies were from high-income countries and applied quantitative intervention designs. Just under half targeted children, most at the population level. Approximately one in three studies used behavioural theory to guide intervention development. Few studies reported formative research.

Conclusion
The past decade has seen a threefold increase in the number of papers describing public health interventions to prevent children drowning. Despite this increase, interventions remain primarily educational, focusing on behavioural strategies. A call for more comprehensive and systems-level interventions that tackle the upstream determinants of child drowning is timely.
Modeling and analysis of gradient metamaterials for broad fusion bandgaps
Authors: Cai Changqi , Zhu Chenjie , Zhang Fengyi , Sun Jiaojiao , Wang Kai , Yan Bo , Zhou Jiaxi 
Published: July 2024

AbstractA gradient metamaterial with varying-stiffness local resonators is proposed to open the multiple bandgaps and further form a broad fusion bandgap. First, three local resonators with linearly increasing stiffness are periodically attached to the spring-mass chain to construct the gradient metamaterial. The dispersion relation is then derived based on Bloch’s theorem to reveal the fusion bandgap theoretically. The dynamic characteristic of the finite spring-mass chain is investigated to validate the fusion of multiple bandgaps. Finally, the effects of the design parameters on multiple bandgaps are discussed. The results show that the metamaterial with a non-uniform stiffness gradient pattern is capable of opening a broad fusion bandgap and effectively attenuating the longitudinal waves within a broad frequency region.
A low-frequency and broadband wave-insulating vibration isolator based on plate-shaped metastructures
Authors: Wei Wei , Guan Feng , Fang Xin 
Published: July 2024

AbstractA metamaterial vibration isolator, termed as wave-insulating isolator, is proposed, which preserves enough load-bearing capability and offers ultra-low and broad bandgaps for greatly enhanced wave insulation. It consists of plate-shaped metacells, whose symmetric and antisymmetric local resonant modes offer several low and broad mode bandgaps although the complete bandgap remains high and narrow. The bandgap mechanisms, vibration isolation properties, effects of key parameters, and robustness to complex conditions are clarified. As experimentally demonstrated, the wave-insulating isolator can improve the vibration insulation in the ranges of [50 Hz, 180 Hz] and [260 Hz, 400 Hz] by 15 dB and 25 dB, respectively, in contrast to the conventional isolator with the same first resonant frequency.
On Klein tunneling of low-frequency elastic waves in hexagonal topological plates
Authors: Yao Yuxin , Ma Yuansheng , Hong Fang , Zhang Kai , Wang Tingting , Peng Haijun , Deng Zichen 
Published: July 2024

AbstractIncident particles in the Klein tunnel phenomenon in quantum mechanics can pass a very high potential barrier. Introducing the concept of tunneling into the analysis of phononic crystals can broaden the application prospects. In this study, the structure of the unit cell is designed, and the low frequency (< 1 kHz) valley locked waveguide is realized through the creation of a phononic crystal plate with a topological phase transition interface. The defect immunity of the topological waveguide is verified, that is, the wave can propagate along the original path in the cases of impurities and disorder. Then, the tunneling phenomenon is introduced into the topological valley-locked waveguide to analyze the wave propagation, and its potential applications (such as signal separators and logic gates) are further explored by designing phononic crystal plates. This research has broad application prospects in information processing and vibration control, and potential applications in other directions are also worth exploring.
Visual Attention to Evolutionarily Relevant Information by Heterosexual Men and Women While Viewing Mock Online Dating Profiles
Authors: Gale Madeleine , Torbay Rosemary , Lykins Amy D. 
Published: July 2024

AbstractThe way people create social connections and access information has been altered greatly by technology in recent decades. Online browsing of visual profiles has become a common means for seeking potential partners for both short- and long-term relationships. Little is known, however, about how people prioritize mate quality information while viewing online profiles. Using eye-tracking methods and self-report, this study investigated how people evaluated profile-based facial attractiveness and text-based financial resources information, represented by income and occupation. Heterosexual male and female participants, aged between 18 and 27 years, viewed opposite-sex profiles while their eye-movements were recorded using a remote eye-tracking camera. In line with current theory, resources information had little effect on men’s overall attention to women’s faces, whereas women’s overall attention to men’s faces varied depending on the level of income and occupation. Women evaluated men’s faces more when income and occupation were low, regardless of attractiveness. Unexpectedly, however, men marginally increased their attention toward unattractive women who showed a high-level of income and more esteemed occupation. Men self-reported a higher interest in women for a short-term relationship and women self-reported a higher interest in men for a long-term relationship. This work provides a foundation to further examine how people browse profile-based information and to investigate the mate selection process, with real-world implications for online dating app users, profile design, and content.
Sex ratio at birth across 100 years in Sweden and risk of cardiovascular disease and all-cause mortality – a national register study
Authors: Nilsson Peter M. , Sundquist Kristina , Sundquist Jan , Crump Casey , Li Xinjun 
Published: July 2024

AbstractThe human sex ratio at birth (SRB) undergoes temporary changes around a mean proportion of 0.51 male births. SRB has been well studied for historical, geographical, and secular trends, but until now not linked to health outcomes in the total population, e.g. for cardiovascular disease (CVD) or mortality during follow-up of birth cohorts. We used linkage analysis based on national registers in Sweden that cover all births from 1900 to 2016. SRB at birth was calculated by every 10-year birth cohort in all survivors living in 1997 for a follow-up analysis of risk of CVD and mortality with data from national registers. When the highest quartile of SRB was used as reference, a slightly increased risk of fatal CVD (HR 1.03 (95% confidence intervals, CI): 1.02–1.04), non-fatal CVD (HR 1.01; 95%CI: 1.01–1.02) and mortality (HR 1.02; 95%CI, 1.01–1.03) was found after full adjustments in men belonging to the lowest SRB quartile. A similar pattern was also found for fatal CHD in women. in the lowest SBR quartile compared to the highest, HR 1.03 (95%CI: 1.02–1.05). In conclusion, in birth cohorts with a relatively lower than expected number of males born, long-term adverse health effects were observed with slightly increased cardiovascular risk and total mortality at the population level. This could indicate that men belonging to so-called “culled cohorts” in a developed country during the 20th century are characterized by a slightly increased risk that could reflect negative early life influences and environmental exposures in pregnant women resulting in selective loss of male embryos or fetuses. In a public health perspective SRB could be of some importance to monitor as an aspect of birth statistics linked to relatively minor population health effects.
Multi-biobank Mendelian randomization analyses identify opposing pathways in plasma low-density lipoprotein-cholesterol lowering and gallstone disease
Authors: Yang Guoyi , Mason Amy M. , Gill Dipender , Schooling C. Mary , Burgess Stephen 
Published: July 2024

AbstractPlasma low-density lipoprotein (LDL)-cholesterol is positively associated with coronary artery disease risk while biliary cholesterol promotes gallstone formation. Different plasma LDL-cholesterol lowering pathways may have distinct effects on biliary cholesterol and thereby gallstone disease risk. We conducted a Mendelian randomization (MR) study using data from the UK Biobank (30,547 gallstone disease cases/336,742 controls), FinnGen (34,461 cases/301,383 controls) and Biobank Japan (9,305 cases/168,253 controls). We first performed drug-target MR analyses substantiated by colocalization to investigate the effects of plasma LDL-cholesterol lowering therapies on gallstone disease risk. We then performed clustered MR analyses and pathway analyses to identify distinct mechanisms underlying the association of plasma LDL-cholesterol with gallstone disease risk. For a 1-standard deviation reduction in plasma LDL-cholesterol, genetic mimics of statins were associated with lower gallstone disease risk (odds ratio 0.72 [95% confidence interval 0.62, 0.83]), but genetic mimics of PCSK9 inhibitors and targeting apolipoprotein B were associated with higher risk (1.11 [1.03, 1.19] and 1.23 [1.13, 1.35]). The association for statins was supported by colocalization (posterior probability 98.7%). Clustered MR analyses identified variant clusters showing opposing associations of plasma LDL-cholesterol with gallstone disease risk, with some evidence for ancestry-and sex-specific associations. Among variants lowering plasma LDL-cholesterol, those associated with lower gallstone disease risk were mapped to glycosphingolipid biosynthesis pathway, while those associated with higher risk were mapped to pathways relating to plasma lipoprotein assembly, remodelling, and clearance and ATP-binding cassette transporters. This MR study provides genetic evidence that different plasma LDL-cholesterol lowering pathways have opposing effects on gallstone disease risk.
Quantitative indicators for environmental and social sustainability performance assessment of the supply chain
Authors: Okay Nilufer C. , Sencer Asli , Taskin Nazim 
Published: July 2024

AbstractIn the era of globalization, supply chains are becoming less transparent, facing pressing sustainability challenges such as the inappropriate use of natural resources, poor working conditions, and environmental degradation. This paper addresses these issues by presenting a pioneering sustainability assessment framework aimed at increasing transparency and accountability in global supply chains. Emerging from a systematic literature review and insights from the Global Reporting Initiative (GRI), the framework comprises 91 robust performance indicators: 36 environmental and 55 social. These indicators, a mix of quantitative and semi-quantitative measures, provide a comprehensive tool for assessing the sustainability performance of supply chain actors across a range of sectors. The framework not only facilitates companies in measuring their own and their suppliers’ sustainability performance but also enhances their capacity to effectively communicate their environmental and social progress to stakeholders. Additionally, it is designed to seamlessly integrate with Industry 4.0 technologies, enabling more dynamic assessments.
The BCR::ABL1 tyrosine kinase inhibitors ponatinib and nilotinib differentially affect endothelial angiogenesis and signalling
Authors: Zibrova Darya , Ernst Thomas , Hochhaus Andreas , Heller Regine 
Published: July 2024

Abstract
BCR::ABL1 inhibitors, the treatment of choice for the majority of patients with chronic myeloid leukaemia (CML), can cause vascular side effects that vary between agents. The exact underlying mechanisms are still poorly understood, but the vascular endothelium has been proposed as a site of origin. The present study investigates the effects of three BCR::ABL1 inhibitors, ponatinib, nilotinib and imatinib, on angiogenesis and signalling in human endothelial cells in response to vascular endothelial growth factor (VEGF). The experiments were performed in endothelial cells isolated from human umbilical veins. After exposure to imatinib, ponatinib and nilotinib, the angiogenic capacity of endothelial cells was assessed in spheroid assays. VEGF-induced signalling pathways were examined in Western blotting experiments using different specific antibodies. RNAi technology was used to downregulate proteins of interest. Intracellular cGMP levels were measured by ELISA. Imatinib had no effect on endothelial function. Ponatinib inhibited VEGF-induced sprouting, while nilotinib increased spontaneous and VEGF-stimulated angiogenesis. These effects did not involve wild-type ABL1 or ABL2, as siRNA-mediated knockdown of these kinases did not affect angiogenesis and VEGF signalling. Consistent with their effects on sprouting, ponatinib and nilotinib affected angiogenic pathways in opposite directions. While ponatinib inhibited VEGF-induced signalling and cGMP formation, nilotinib activated angiogenic signalling, in particular phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2). The latter occurred in an epidermal growth factor receptor (EGFR)-dependent manner possibly via suppressing Fyn-related kinase (FRK), a negative regulator of EGFR signalling. Both, pharmacological inhibition of Erk1/2 or EGFR suppressed nilotinib-induced angiogenic sprouting. These results support the notion that the vascular endothelium is a site of action of BCR::ABL1 inhibitors from which side effects may arise, and that the different vascular toxicity profiles of BCR::ABL1 inhibitors may be due to their different actions at the molecular level. In addition, the as yet unknown pro-angiogenic effect of nilotinib should be considered in the treatment of patients with comorbidities associated with pathological angiogenesis, such as ocular disease, arthritis or obesity.
Neural modeling of power nonlinear inductors by the E-$$\alpha $$Net network
Authors: Pilato Giovanni , Vitale Gianpaolo , Vassallo Giorgio , Scirè Daniele 
Published: July 2024

AbstractIn this paper, a model for nonlinear ferrite power inductors based on the $$\alpha $$
α
Net neural network is proposed. The model is able to reproduce the ferrite power inductors inductor behavior up to saturation, considering the core temperature. The $$\alpha $$
α
Net neural network was used for its generalization capability considering a hybrid approach encompassing a classical weighted interpolation. The model’s effectiveness was experimentally verified by calculating the current flowing through two inductors in an electric circuit in different operating conditions, and has been compared with the two main models found in literature to show the improvement both in terms of the maximum value of the estimated current and the root mean square error. The modeling procedure can be easily extended to inductors with different sizes and core materials due to the features of the $$\alpha $$
α
Net network and the hybrid approach to retrieve data.
Clinical management protocols for community pharmacist-led management of urinary tract infections: a review of the grey literature and quality appraisal
Authors: Budden Mitchell , Gilbertson Daniel , Chung Sean , Benrimoj Shalom I. , Mardones Francisco , Dineen-Griffin Sarah 
Published: July 2024

Abstract
Background
Pharmacist-led management of urinary tract infections has been introduced as a service in the United Kingdom, Canada, United States of America, New Zealand, and Australia. The management of acute uncomplicated urinary tract infections by community pharmacists has gained increasing attention as a potential avenue to alleviate the burden on primary healthcare services.

Aim
The objectives of the review were to: (1) identify protocols for community pharmacist management of acute uncomplicated urinary tract infections in women aged 16–65 years; (2) outline their key components; and (3) appraise the quality of protocols.

Method
A grey literature search was undertaken for protocols intended for use by community pharmacists for the management of acute uncomplicated urinary tract infections in women aged 16–65 years, met the definition of a clinical management protocol and written in English. Their quality was appraised using the Appraisal Guidelines for Research and Evaluation version II instrument.

Results
Forty of the 274 records screened were included. Content analysis identified ten key components: common signs/symptoms, differential diagnosis, red flags/referral, choice of empirical antibiotic therapy, nonprescription medications, nonpharmacological/self-care advice, patient eligibility criteria, patient follow-up, dipstick testing recommendations, and recommendations on antimicrobial resistance. The lowest scoring domains in the quality assessment were ‘Editorial Independence’ and ‘Rigour of Development’. Only four protocols were deemed high-quality.

Conclusion
The review demonstrates that clinical management protocols for pharmacist-led management of urinary tract infections consist of similar recommendations, despite variation in international practice. However, the findings highlight a deficiency in the quality of most clinical management protocols governing pharmacist-led urinary tract infection management.
Anticholinergic burden and health-related quality of life among adult patients in a resource-limited setting: a cross-sectional study
Authors: Gebreyohannes Eyob Alemayehu , Shibe Biniam Siyum , Taye Wagaye Atalay , Lee Kenneth , Abdela Ousman Abubeker , Ayele Emneteab Mesfin , Belachew Eyayaw Ashete , Mengistu Segenet Bizuneh , Myint Phyo Kyaw , Soiza Roy Louis 
Published: July 2024

Abstract
Background
Anticholinergic medications are now widely acknowledged for their unfavorable risk-to-benefit profile owing to their adverse effects. Health-related quality of life (HRQoL) is commonly regarded as a crucial person-centered outcome.

Aim
This study aimed to investigate the association between anticholinergic burden and HRQoL in hospitalized and ambulatory patients seen in Ethiopia.

Method
This cross-sectional study utilized a questionnaire and medical records to collect data from a convenience sample of adult patients attending both inpatient wards and ambulatory clinic of University of Gondar Comprehensive Specialized Hospital between April and September 2022. Anticholinergic burden was measured by anticholinergic cognitive burdens scale (ACBS), while HRQoL was measured using EQ5D-index (Euroqol-5 dimensions-5-Levels index) and EQ5D-VAS (visual analogue scale). Linear regression was used to assess the influence of high anticholinergic burden (ACBS score ≥ 3) on EQ5D-index and EQ5D-VAS, with adjustments made for sociodemographic and clinical confounders.

Results
A total of 828 patients participated in this study (median (IQR) age was 45.0 (30, 60) and 55.9% were female). On multiple linear regression analysis, high anticholinergic burden was associated with a statistically significant decline in HRQoL, as evidenced by reductions in both EQ5D index (− 0.174 (− 0.250, − 0.098)) and EQ5D-VAS scores (− 9.4 (− 13.3, − 5.2)).

Conclusion
A significant association between high anticholinergic burden and diminished HRQoL was found among a relatively younger cohort in a resource-limited setting, even after adjustment for important confounding variables. Clinicians should be cognizant of the cumulative impact of anticholinergic burden on HRQoL outcomes and strive to minimize anticholinergic burden.