bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Prognostic Significance of Hepatic Marker Variations in COVID-19 Patients: A Cross-Sectional Analysis in Sabzevar, Iran
Authors: Sharifi Dalouei Seyed AminReza , Molavi Mehdi , Amin Bahareh , Amiri Parastoo , Mahdavifar Neda 
Published: August 2024

Background:
Since the emergence of COVID-19 in early 2020, increased hepatic markers
have been reported, indicating potential vulnerability and predictive value for patient outcomes.
Hence, this study investigated the impact of COVID-19 on liver function markers and their association
with clinical outcomes.

Methods:
In this cross-sectional study, 392 PCR or CT-Scan confirmed COVID-19 patients from
Sabzevar and Mashhad, Iran, were categorized into outpatients, mild-to-moderate, and severe hospitalization
groups. Liver enzymes, including AST, ALT, and ALP, were measured, and their associations
with disease severity and outcomes were analyzed.

Results:
Of the participants, 130 were outpatients, and 262 were hospitalized, with a higher male
predominance in severe cases. Inpatients showed significantly elevated ALP compared to outpatients.
Severe inpatients exhibited higher initial blood sugar levels and longer hospital stays. Elevated
AST and ALT levels were notable in ICU admissions and patients requiring mechanical ventilation.
A significant difference in pre-admission AST levels was observed between deceased and recovered
patients. No correlation was found between liver enzymes and factors like gender, blood oxygen
level, respiratory rate, fever, and BMI.

Conclusion:
Elevated liver enzymes, particularly AST and ALT, are indicative of COVID-19 severity
and can predict the need for intensive care and mechanical ventilation. AST levels may also serve
as a prognostic marker for patient outcomes. These findings highlight the importance of monitoring
liver function in COVID-19 management.
Novel Approaches of Inhalational Therapy for COVID-19: Drugs to Vaccines
Authors: Bramhe Pratiksha , Waghmare Suchita , Rarokar Nilesh , Potey Lata , Dibbe Bhupendra , Sable Prafulla , Khedekar Pramod , Sabale Vidya , Prajapati Bhupendra 
Published: August 2024

Abstract:
Inhalational therapy has emerged as a pivotal modality in the management of COVID-19,
offering targeted and efficient delivery of pharmaceutical agents directly to the respiratory system.
This paper provides a comprehensive overview of the diverse inhalational approaches employed in
the treatment of COVID-19, ranging from nebulizers to nasal sprays. The various mechanisms of
action, efficacy, and safety profiles of various inhalational treatments, considering both antiviral
medications and supportive therapies. The evolution of inhalational therapy during the course of the
pandemic is also mentioned in this review, emphasizing the continuous efforts to optimize delivery
methods and enhance patient outcomes. Furthermore, the paper addresses the challenges associated
with implementing inhalational therapies on a global scale, considering factors such as accessibility,
affordability, and regulatory considerations. By giving special emphasis on current research and
clinical experiences, this review contributes to a deeper understanding of the role of inhalational
therapy in combating COVID-19 patients with multiple infections like DM and hypoglycemia.
Holistic Management in Pulmonary Tuberculosis Patients with Malnutrition
Authors: Karyus Aila 
Published: August 2024

Background: Tuberculosis (TB) is still a problem in developing countries and even the world. TB is one of the top 10 causes of death and the first cause of death from an infectious agent worldwide. The government plans to eliminate TB by 2030, which is carried out with the National Strategy for TB Control. Family doctors play an important role in which the role of family doctors is not only to cure but also to promote health and prevention of TB disease. Purpose: The application of evidence-based medical doctor family services to patients by identifying risk factors, clinical problems, and management with a patient-centered approach and family approach. Method: The study conducted was a Case Report. Primary data were obtained through history taking and physical examination by making home visits, filling family folders, and filling patient files. The assessment was carried out based on the initial holistic diagnosis, process, and end of the visit quantitatively and qualitatively. Results: Based on a holistic diagnosis, it was found that an 87-year-old patient complained of coughing, difficulty in swallowing, and weight loss since three months ago, three weeks ago the patient was diagnosed with TB. Physical examination showed a BMI of 14.2. The patient had difficulty swallowing, with the examination of nerves 10 within normal limits. Internal risk factors include a lack of knowledge about TB, and aging. External factors are often exposed to dust. Functional degrees 4. Four visits were made. The interventions provided in the form of education about TB include the definition, symptoms, treatment and prevention, counseling with the family, and providing a high-calorie, high-protein diet for patients. The evaluation results show an increase in patient and family knowledge about TB and an improvement in the patient's diet that the family has done. Conclusion: The diagnosis of TB with malnutrition and dysphagia is good. Management provided is in accordance with the guidelines, visible changes in behavior, and knowledge of patients and patients' families after an intervention based on evidence-based medicine that is patient-centered, family approach.
Empowerment of Dasawisma and Health Cadres as Family Cadres to Optimize Family Posyandu
Authors: Fitriadi Yogi , Mahmudah Noor Afif , Ekawati Fitriana Murriya , Fauziah Siti Rizki , Ngang Inggong , Nababan Adelina Novita , Claramita Mora 
Published: August 2024

Background: Health cadres are one of the important elements in realizing health in society. In the North Lombok region, the change in the status of ordinary Posyandu to family Posyandu makes health care in the community more comprehensive for all family members. For this reason, efforts to increase the capacity of health cadres are important to improve health status in the family sphere. Objective: This study aims to see the effect of training on increasing the capacity of family cadres on the knowledge of family cadres in the North Lombok Regency area. Method: The sampling process is carried out using the cluster sampling method where each village representative in the Kayangan sub-district of North Lombok Regency sends a cadre representative to train to increase the capacity of Dasawisma cadres to become family cadres. A descriptive analysis of respondents' characteristics and differences in knowledge scores before and after family cadre training activities were conducted. The data analysis process was carried out with the Wilcoxon Test because the data distribution was abnormal. Result: Thirty-three health cadres meet the inclusion and exclusion criteria. The results showed that the median value (maximum-minimum) of family cadres before training, shortly after training and six months after training was 66.67 (36.67-80), 66.67 (53.33-83.33) and 70 (53.33-96.67). From the Wilcoxon test, there was a statistically significant difference between the knowledge score before training and six months after training (p<0.05). There was no statistically significant difference between the knowledge score before training and shortly after training, as well as the knowledge score shortly after training and 6 months after training (p>0.05). Conclusion: Family cadre empowerment training can improve knowledge scores 6 months after training, but there is no significant difference in knowledge score improvement shortly after training as well as between knowledge scores shortly after training and 6 months after training.
THEOPHYLLINE ASCORBIC ACID COCRYSTALS BY SONOCRYSTALLIZATION METHOD: FORMULATION AND CHARACTERIZATION STUDIES
Authors: HARITA R DESAI  , SAKSHI JAISWAL  , ASHWINI KONDHARE  
Published: August 2024

Objective: The objective of the current research work was to develop Theophylline Ascorbic acid cocrystals by sonocrystallization method. The approach is a coadministrative approach to provide drug:drug cocrystals in Chronic Obstructive Pulmonary Disorder.
Methods:The cocrystals were formulated in 3 stoichiometric ratios of 1:1, 1:2 and 2:1 using Sonocrystallization induced evaporation method. Methanol was used as solvent. The cocrystals were evaluated for visual morphology, melting point, FTIR studies, saturation solubility in water and Simulated Lung fluid pH 7.4, in vitro drug release in Simulated Lung Fluid pH 7.4, Differential scanning calorimetry studies, X-Ray Diffraction studies, Scanning Electron Microscopy studies and Raman spectroscopy.
Result:Cocrystals were successfully developed in all 3 stoichiometric ratios by sonocrystallization method. The cocrystal of Theophylline with Ascorbic acid in ratio of 1:1 was found to be most optimized with 10 fold increase in saturation solubility in water and 11.5 fold increase in solubility in simulated lung fluid pH 7.4 and two-fold increase in in vitro drug release in SLF pH 7.4. The cocrystal was found to show a lowered melting point as confirmed by DSC studies thus confirming formation of new crystalline phase. X Ray Diffraction studies. SEM and Raman spectroscopy studies were found to confirm the change in crystalline characteristics of the cocrystals by indicating formation of new crystalline phase.
Conclusion: Cocrystals were successfully developed by sonocrystallization method. Sonocrystallization method can be used as a preferred method for formation of drug-drug cocrystals for coadministrative approach of drug delivery.
Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights From a Prospective Cohort Study
Authors: Huang Ze-Gui , Gao Jing-Wei , Chen Zhi-Teng , Zhang Hai-Feng , You Si , Xiong Zhuo-Chao , Wu Yu-Biao , Gao Qing-Yuan , Wang Jing-Feng , Chen Yang-Xin , Zhang Shao-Ling , Liu Pin-Ming 
Published: August 2024

OBJECTIVE
The impact of comprehensive risk factor control on heart failure (HF) risk and HF-free survival time in individuals with type 2 diabetes (T2D) was evaluated in this study.

RESEARCH DESIGN AND METHODS
This prospective study included 11,949 individuals diagnosed with T2D, matched with 47,796 non-T2D control study participants from the UK Biobank cohort. The degree of comprehensive risk factor control was assessed on the basis of the major cardiovascular risk factors, including blood pressure, BMI, LDL cholesterol, hemoglobin A1c, renal function, smoking, diet, and physical activity. Cox proportional hazards models were used to measure the associations between the degree of risk factor control and HF risk. Irwin’s restricted mean was used to evaluate HF-free survival time.

RESULTS
During a median follow-up of 12.3 years, 702 individuals (5.87%) with T2D and 1,402 matched control participants (2.93%) developed HF. Each additional risk factor controlled was associated with an average 19% lower risk of HF. Optimal control of at least six risk factors was associated with a 67% lower HF risk (hazard ratio [HR] 0.33; 95% CI 0.20, 0.54). BMI was the primary attributable risk factor for HF. Notably, the excess risk of HF associated with T2D could be attenuated to levels comparable to those of non-T2D control participants when individuals had a high degree of risk factor control (HR 0.66; 95% CI 0.40, 1.07), and they exhibited a longer HF-free survival time.

CONCLUSIONS
Comprehensive management of risk factors is inversely associated with HF risk, and optimal risk factor control may prolong HF-free survival time among individuals with T2D.
On the importance of teaching the humanities in higher education
Authors: Марков Е.А. 
Published: August 2024

Статья посвящена проблематике значения преподавания гуманитарных дисциплин при подготовке специалистов в высшей школе. Важность преподавания гуманитарных дисциплин рассматривается в аспекте наблюдаемой сегодня тенденции дегуманитаризации образования, являющейся следствием: а) сокращения объемов преподаваемых студентам гуманитарных дисциплин; б) отсутствием в образовательной политике четкой позиции о важности гуманитарных знаний для специалистов всех направлений подготовки. Доказывая необходимость гуманитаризации сферы образования, автор опирается на теоретические положения и результаты исследований ученых (философов, лингвистов), а также на мнения специалистов-практиков. Основной вывод, сделанный автором, следующий: гуманитарная составляющая должна наполнять все уровни системы образования, начиная со школы и заканчивая институтом / университетом. Гуманитаризация образования позволит ликвидировать разрыв в овладении специалистами естественнонаучных, технических и гуманитарных знаний.
The author of the article focuses on the importance of teaching humanities while training specialists in higher education. The importance of teaching humanities is considered in the context of the current trend of dehumanitarisation of education, which is a consequence of: a) the reduction in the number of humanities subjects taught to students; b) the lack of a clear position in educational policy on the importance of humanities knowledge for specialists in all areas of training. In proving the necessity of humanitarisation of education, the author relies on theoretical provisions and research results of scientists (philosophers, linguists) as well as on the opinions of practitioners. The main conclusion made by the author is as follows: the humanitarian component should fill all levels of the education system, starting from school and ending with institute or university. Humanitarisation of education will help to eliminate the gap in the mastery of natural science, technical and humanitarian knowledge by specialists.
On the polysemy of a lexical unit in the dictionary and in the context (comparative analysis on the material of explanatory dictionaries and a publicistic text)
Authors: Королева В.В. , Румянцева М.С. 
Published: August 2024

В статье рассматривается понятие многозначности, изучается семантическое содержание лексической единицы market и приводится сравнительный анализ значений лексемы на базе четырех толковых словарей. Целью исследования является изучение способов объяснения явления рынка в лексикографических источниках, а также сравнение определений лексемы market, зафиксированных в словарях, со значениями, реализующимися в публицистическом тексте журнала “The Economist”. Актуальность исследования обусловлена необходимостью обновления лексикографических данных о понятии рынка и создания концептуальной модели данного явления в экономике. Делается вывод о связи определений в рамках статьи в конкретном словаре посредством интегрирующей семы или с помощью усиления выраженности эмоционального компонента. Образование переносных значений с помощью метафоры и метонимии часто является предпосылкой развития концепта «рынок». В ходе исследования в текстах журнала были выявлены некоторые значения лексемы market, не упомянутые в словаре.
The article discusses the concept of polysemy, studies the semantic content of the lexical unit ‘market’ and provides a comparative analysis of its meanings based on four explanatory dictionaries. The purpose of the research is to study the ways of explaining the phenomenon of the market in lexicographic sources, as well as to compare the definitions of the lexeme ‘market’, recorded in dictionaries, with the meanings updated in the journalistic text of The Economist. The relevance of the study is due to the need to renew lexicographic data on the concept of the market as an economic institution, since these data allow us to model a conceptual representation of the studied mental knowledge. The conclusion is made about the connection of definitions within an article in a particular dictionary by means of an integrating seme or by increasing expressiveness of the emotional component in the meaning of the word. The development of figurative meanings by means of metaphor and metonymy is often a prerequisite for the development of the ‘market’ concept. In the course of the study, some meanings of the lexeme market, not mentioned in the dictionary, were identified in the journalistic texts.
Development of the satire genre in the works by the classics of Dagestani literature Y. Kazak and E. Emin
Authors: Ханбалаева С.Н. , Халидова Ю.Р. 
Published: August 2024

Статья посвящена анализу острых социальных мотивов в лирике Йырчи Казака (1830–1879) и Етим Эмина (1838–1898), чье творчество оказало заметное влияние на развитие жанровых форм в дагестанской поэзии второй половины XIX века, в том числе и жанра сатиры. Цель статьи – показать, как, сохраняя и развивая идущую из глубины веков поэтическую традицию, лирика Й. Казака и Е. Эмина расширила жанровые и стилистические границы дагестанской литературы. Новизна исследования заключается в том, что впервые рассматривается роль классиков кумыкской и лезгинской литературы в формировании и развитии жанра сатиры как важнейшего направления в генезисе дагестанской художественной словесности.
The works by Dagestani classical poets Yirchi Kazak (1830-1879) and Etim Emin (1838-1898) are closely connected with the traditions of national folklore, eastern artistic cultures, as well as with the political and cultural processes of Dagestan and Russia in the late XIX century. The main objects of the study are satirical works by the Kumyk poet Y. Kazak and the Lezgin poet E. Emin. The aim of the article is to show that due to the poetic tradition coming from the depths of centuries, the lyrics of Y. Kazak and E. Emin expanded genre and stylistic boundaries of Dagestani literature. The novelty of the study lies in the fact that for the first time the authors of the article consider the role of the classics of Kumyk and Lezgin literature in the development of the satire genre as the most important direction in the genesis of Dagestani fiction.
Teaching Materials Containing Papuan Cultural Wisdom to Develop Children's Story Writing Skills in Class V Elementary Schools
Authors: Kasse Fransiskus , Sudiyanto  , Yulisetiani Septi 
Published: August 2024

Developing teaching materials containing Papuan cultural wisdom is an important step in improving writing skills and overcoming the challenge of low literacy levels of students in Papua. This research aims to develop teaching materials containing Papuan cultural wisdom to improve students' writing skills. This R&D research focuses on developing teaching materials using the 4D model, namely Define, Design, Development and Dissemination. The subjects in this research were fifth grade elementary school students with a sample of 70 students in the control class and experimental class. Data collection was carried out by observation, interviews, questionnaires and documentation. Data analysis was carried out using interactive analysis techniques, validation and product testing. Apart from that, the data was also analyzed using qualitative descriptive analysis and quantitative analysis. The results of the study showed an increase in the average pretest score in the control class to 67.3, while the experimental class reached 69.5. After the treatment was carried out and ended with the post-test, there was an increase in the average score in the control class to 75.73, and the experimental class 90.28. The higher average increase in post-test scores in the experimental class indicates the potential for increasing students' understanding by using Papuan cultural wisdom teaching materials. Innovation in teaching materials with Papuan cultural wisdom theoretically has implications for complementing and strengthening previous theories regarding teaching materials and story writing skills. Practically, the results of this research can contribute to Papuan cultural wisdom and effectively improve elementary school students' short story writing skills.
Determinan Faktor Individu dan Sosial yang Berhubungan dengan Literasi Kesehatan Mental pada Mahasiswa di Universitas Malahayati
Authors: Syarifah Dinda Rachma , Angelina Christin , Muhani Nova , Reni Octa 
Published: August 2024

Berdasarkan data Riskesdas di Provinsi Lampung pada tahun 2018 menyebutkan gangguan mental emosional sebesar 5,56%. Pada sampai saat ini, kesehatan mental menjadi masalah yang belum dapat sepenuhnya diselesaikan, baik tingkat global maupun nasional. Akar permasalahan pada kesehatan mental yaitu pemahaman mahasiswa yang kurang mengenai literasi khususnya literasi kesehatan mental. Tujuan penelitian ini untuk mengetahui hubungan usia, jenis kelamin, pendidikan, pendapatan ekonomi orang tua, bahasa, dan penggunaan media sosial terhadap literasi kesehatan mental pada mahasiswa di universitas malahayati.
Penelitian ini menggunakan desain penelitian kuantitatif dengan pendekatan cross sectional. Analisis data menggunakan analisa univariat dan bivariat dengan menggunakan uji Chi-square. Populasi pada penelitian ini adalah mahasiswa aktif universitas malahayati sebanyak 218 responden. Teknik pengumpulan data melalui kuesioner berbentuk google form.
Hasil penelitian ini menunjukan berdasarkan univariat literasi kesehatan mental tinggi (71,1%), usia 20-24 tahun (67,4%), jenis kelamin perempuan (81,7%), pendidikan SMA (82,1%), pendapatan ekonomi rendah UMP <2.633.000 ( 50,9%), bahasa Indonesia (98,2%), jenis media sosial content communities (81,7%). Hasil uji bivariat menunjukkan bahwa ada hubungan variabel usia (p-value 0,000), pendapatan ekonomi orang tua (p-value 0,001) berhubungan dengan literasi kesehatan mental. Tidak ada hubungan terhadap literasi kesehatan mental antara lain pendidikan (p-value 0,604), bahasa (p-value 1,00), penggunaan media sosial (p-value 0,057).
Peniliti menyarankan kepada responden untuk meningkatkan literasi kesehatan mental dengan cara memanfaatkan informasi yang tersedia di instansi atau mengakses media sosial untuk mengikuti akun-akun yang membahas terkait kesehatan mental. Namun, pastikan bahwa akun-akun tersebut menyajikan konten positif.