bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma
Authors: Staaf Johan , Isaksson Sofi , Karlsson Anna , Jönsson Mats , Johansson Leif , Jönsson Per , Botling Johan , Micke Patrick , Baldetorp Bo , Planck Maria 
Published: October 2012

AbstractLung cancer is the worldwide leading cause of death from cancer and has been shown to be a heterogeneous disease at the genomic level. To delineate the genomic landscape of copy number alterations, amplifications, loss‐of‐heterozygosity (LOH), tumor ploidy and copy‐neutral allelic imbalance in lung cancer, microarray‐based genomic profiles from 2,141 tumors and cell lines including adenocarcinomas (AC, n = 1,206), squamous cell carcinomas (SqCC, n = 467), large cell carcinomas (n = 37) and small cell lung carcinomas (SCLC, n = 88) were assembled from different repositories. Copy number alteration differences between lung cancer histologies were confirmed in 285 unrelated tumors analyzed by BAC array comparative genomic hybridization. Tumor ploidy patterns were validated by DNA flow cytometry analysis of 129 unrelated cases. Eighty‐nine recurrent copy number alterations (55 gains, 34 losses) were identified harboring genes with gene expression putatively driven by gene dosage through integration with gene expression data for 496 cases. Thirteen and 26 of identified regions discriminated AC/SqCC and AC/SqCC/SCLC, respectively, while 48 regions harbored recurrent (n > 15) high‐level amplifications comprising established and putative oncogenes, differing in frequency and coamplification patterns between histologies. Lung cancer histologies displayed differences in patterns/frequency of copy number alterations, genomic architecture, LOH, copy‐neutral allelic imbalance and tumor ploidy, with AC generally displaying less copy number alterations and allelic imbalance. Moreover, a strong association was demonstrated between different types of copy number alterations and allelic imbalances with tumor aneuploidy. In summary, these analyses provide a comprehensive overview of the landscape of genomic alterations in lung cancer, highlighting differences but also similarities between subgroups of the disease.
CEBP factors regulate telomerase reverse transcriptase promoter activity in whey acidic protein‐T mice during mammary carcinogenesis
Authors: Kumar Mukesh , Witt Britta , Knippschild Uwe , Koch Sylvia , Meena Jitendra K. , Heinlein Christina , Weise Julia M. , Krepulat Frauke , Kuchenbauer Florian , Iben Sebastian , Rudolph Karl‐Lenhard , Deppert Wolfgang , Günes Cagatay 
Published: October 2012

AbstractTelomerase is activated in the majority of invasive breast cancers, but the time point of telomerase activation during mammary carcinogenesis is not clear. We have recently presented a transgenic mouse model to study human telomerase reverse transcriptase (TERT) gene expression in vivo (hTERTp‐lacZ). In the present study, hTERTp‐lacZxWAP‐T bitransgenic mice were generated to analyze the mechanisms responsible for human and mouse TERT upregulation during tumor progression in vivo. We found that telomerase activity and TERT expression were consistently upregulated in SV40‐induced invasive mammary tumors compared to normal and hyperplastic tissues and ductal carcinoma in situ (DCIS). Human and mouse TERT genes are regulated similarly in the breast tissue, involving the CEBP transcription factors. Loss of CEBP‐α and induction of CEBP‐β expression correlated well with the activation of TERT expression in mouse mammary tumors. Transfection of CEBP‐α into human or murine cells resulted in TERT repression, whereas knockdown of CEBP‐α in primary human mammary epithelial cells resulted in reactivation of endogenous TERT expression and telomerase activity. Conversely, ectopic expression of CEBP‐β activated endogenous TERT gene expression. Moreover, ChIP and EMSA experiments revealed binding of CEBP‐α and CEBP‐β to human TERT‐promoter. This is the first evidence indicating that CEBP‐α and CEBP‐β are involved in TERT gene regulation during carcinogenesis.
Phosphorylated tubulin adaptor protein CRMP‐2 as prognostic marker and candidate therapeutic target for NSCLC
Authors: Oliemuller Erik , Peláez Rafael , Garasa Saray , Pajares María J. , Agorreta Jackeline , Pío Rubén , Montuenga Luis M. , Teijeira Alvaro , Llanos Susana , Rouzaut Ana 
Published: October 2012

AbstractCollapsin response mediator protein‐2 (CRMP‐2) is the first described and most studied member of a family of proteins that mediate the addition of tubulin dimers to the growing microtubule. CRMPs have mainly been studied in the nervous system, but recently, they have been described in other tissues where they participate in vesicle transport, migration and mitosis. In this work, we aimed at studying the role of CRMP‐2 in lung cancer cell division. We first explored the expression of CRMP‐2 and phosphorylated (Thr 514) CRMP‐2 in 91 samples obtained from patients with localized nonsmall cell lung cancer. We observed a significant correlation between high levels of nuclear phosphorylated CRMP‐2 and poor prognosis in those patients. Interestingly, this association was only positive for untreated patients. To provide a mechanistic explanation to these findings, we used in vitro models to analyze the role of CRMP‐2 and its phosphorylated forms in cell division. Thus, we observed by confocal microscopy and immunoprecipitation assays that CRMP‐2 differentially colocalizes with the mitotic spindle during cell division. The use of phosphodefective or phosphomimetic mutants of CRMP‐2 allowed us to prove that anomalies in the phosphorylation status of CRMP‐2 result in changes in the mitotic tempo, and increments in the number of multinucleated cells. Finally, here we demonstrate that CRMP‐2 phosphorylation impairment, or silencing induces p53 expression and promotes apoptosis through caspase 3 activation. These results pointed to CRMP‐2 phosphorylation as a prognostic marker and potential new target to be explored in cancer therapy.
B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562/adriamycin‐resistant cell line
Authors: Zhou Huimin , Zhang Zhaohai , Liu Chunqing , Jin Changgong , Zhang Jianing , Miao Xiaoyan , Jia Li 
Published: October 2012

AbstractB4GALT1 gene encodes type II membrane‐bound glycoprotein, named β‐1, 4‐galactosyltransferase 1 (β1, 4‐Gal‐T1), which can transfer galactose to acceptor sugars. B4GALT1 gene plays important roles in physiological process and disease development. In this study, we investigate the possible role and mechanism of B4GALT1 gene in multidrug resistance of human leukemia cell line. Significantly, higher expression of B4GALT1 was observed in adriamycin‐resistant (ADR) K562 cell line (K562/ADR) than that in K562 cell line by real‐time polymerase chain reaction and Western blotting. The activity of β1, 4‐Gal‐T1 enzyme, and Galβ‐1,4GlcNAc structures on cell membrane glycoproteins was found at higher levels in K562/ADR cells than those in K562 cells. Further analysis of the B4GALT1 deregulation after using RNA interference approach showed that the silencing of B4GALT1 in K562/ADR cells resulted in increased sensitivity to chemotherapeutic drugs both in vitro and in vivo. The activity of the hedgehog signaling pathway affected the chemosensitivity of K562/ADR cells and was downregulated in K562/ADR cells with suppression of B4GALT1 gene. We hypothesize that B4GALT1 is responsible for the overcoming multidrug resistance in human leukemia therapy via regulating the activity of the hedgehog signaling pathway. © 2012 IUBMB, IUBMB Life, 64(11): 889–900, 2012
Role of androgen receptor polyQ chain elongation in Kennedy's disease and use of natural osmolytes as potential therapeutic targets
Authors: Kumar Raj 
Published: October 2012

AbstractInstability of CAG triplet repeat encoding polyglutamine (polyQ) stretches in the gene for target protein has been implicated as a putative mechanism in several inherited neurodegenerative diseases. Expansion of polyQ chain length in the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA) or Kennedy's disease. Although the mechanisms underlying gain‐of‐neurotoxic function are not completely understood, suggested pathological mechanisms of SBMA involve the formation of AR nuclear and cytoplasmic aggregates, a characteristic feature of patients with SBMA. The fact that certain AR coactivators are sequestered into the nuclear inclusions in SBMA possibly through protein–protein interactions supports the notion that AR transcriptional dysregulation may be a potential pathological mechanism leading to SBMA. AR conformational states associated with aberrant polyQ tract also modulate the interaction of AR with several coactivators. In many cases, such diseases can be treated through protein replacement therapy; however, because recombinant proteins do not cross the blood–brain barrier, the effectiveness of such therapies is limited in case of neurodegenerative diseases that warrant alternative therapeutic approaches. Among different approaches, inhibiting protein aggregation with small molecules that can stimulate protein folding and reverse aggregation are the most promising ones. Thus, naturally occurring osmolytes or “chemical chaperones” that can easily cross the blood–brain barrier and stabilize the functional form of a mutated protein by shifting the folding equilibrium away from degradation and/or aggregation is a useful therapeutic approach. In this review, we discuss the role of polyQ chain length extension in the pathophysiology of SBMA and the use of osmolytes as potential therapeutic tool. © 2012 IUBMB, IUBMB Life, 64(11): 879–884, 2012
3.3: High‐Speed Shift‐Register for High Resolution AMD with Self‐aligned Coplanar a‐IGZO TFTs
Authors: Geng Di , Kang Dong Han , Seok Man Ju , Mativenga Mallory , Jang Jin 
Published: October 2012

AbstractWe report a high speed shift register (SR) for high resolution AMD using self‐aligned coplanar amorphous‐indium‐gallium‐zinc‐oxide (a‐IGZO) thin‐film transistors (TFTs). The SR could operate with clock frequency of 500 kHz without any distortion and ripple at a supply voltage (VDD) of 15 V, which confirm the use of a‐IGZO TFT shift registers for high‐speed and high resolution AMD.
3.4L: Late‐News Paper: Physical Model and Simulation Platform for High‐Level Instability‐Aware Design of Amorphous Oxide Semiconductor Thin‐Film Transistors
Authors: Kim Dae Hwan , Kim Woojoon , Kim Yongsik , Hur Inseok , Bae Minkyung , Kong Dongsik , Jeong Hyun Kwang , Kim Dong Myong , Du Ahn Byung , Kim Gun Hee , Lee Je‐Hun , Nahm Ho‐Hyun , Kim Yong‐Sung 
Published: October 2012

AbstractThe negative bias illumination stress (NBIS)‐induced VT instability of amorphous InGaZnO thin‐film transistors (TFTs) is quantitatively investigated and a shallow donor state‐creation model is proposed as a physical mechanism. Furthermore, the difference between InGaZnO and HfInZnO TFTs in perspective of NBIS‐induced instability is consistently elucidated. We expect that the proposed model and simulation platform are potentially powerful tools for high‐level instability‐aware design of oxide TFT devices and circuits.
4.2: Polymer‐Stabilized Blue‐Phase Material Driven at Low Voltage
Authors: Ishitani Tetsuji , Niikura Yasuhiro , Ikenaga Makoto , Kobayashi Manabu , Kato Momoko , Nagi Tsudoi , Oe Yuko , Nakano Masaru , Seo Satoshi , Hirakata Yoshiharu , Koyama Jun , Yamazaki Shunpei , Sato Rai , Okazaki Kenichi , Katayama Masahiro 
Published: October 2012

AbstractWe achieved low‐voltage driving of a blue‐phase liquid crystal display by employing liquid crystal with high dielectric anisotropy and a chiral material with high helical twisting power. A prototype of a 3.4‐inch polymer‐stabilized blue‐phase display was made, which includes a highly reliable crystalline oxide semiconductor and operates favorably.
5.3: Active Light Field Rendering in Multi‐View Display Systems
Authors: Park Juyong , Nam Dongkyung 
Published: October 2012

AbstractTo provide clear 3D images regardless of the viewer's 3‐dimensional position, we proposed a light field rendering method in multi‐view displays. In the method, we process each light element individually for the viewer's 3D eye positions obtained by eye detection unit. To deliver clear images to the directions of the eyes, we used the models of the angular visibility responses of the light elements. Combining directional rendering with contents matching for the light field elements, we can provide clear image with realistic parallax on multi‐view displays, even whose number of views are not so large.
5.4: The Autostereoscopic System with Diffractive Optical Elements
Authors: Chen Chien‐Yue , Deng Qing‐Long , Lin Boy‐shyh 
Published: October 2012

AbstractIn this paper, we introduce two kind of beam splitter for applied on the autostereoscopic displays, which is diffractive optical element, and holographic optical element. From the results showing the high performance, they have high brightness and suitable three‐dimensional effects that own higher diffractive efficiency and lowest crosstalk.
6.1: Influence of TV Media Content on Display Lifetime and Image Sticking Measurement Techniques
Authors: Johnson Andrew W. , O'Regan Marie , Trujillo Johann 
Published: October 2012

AbstractBoth lifetime and image sticking measurement techniques are well established but are somewhat uncharacteristic of actual TV usage. The purpose of this paper is to quantify TV usage under various media categories and propose modifications to the standard experimental techniques to better represent the usage demands from TV media.
6.2: Viewing Angle Measurements on Reflective E‐Paper Displays
Authors: Hertel Dirk 
Published: October 2012

AbstractThe viewing angle characterization of reflective displays is more demanding than for emissive displays because defined illumination‐detection geometries must be maintained for each viewing angle. In addition, the geometry should mimic the behavior of a viewer who tends to exclude the reflection of discrete sources from a handheld reflective display. This paper explores strategies to gain viewing angle data from measured Bidirectional Reflectance Distribution Functions (BRDF).
6.4: A Computational Color Difference Metric to Evaluate the Viewing Angle Range for FPDs
Authors: Wen Chao‐Hua 
Published: October 2012

AbstractThe viewing angle characteristics of displays were evaluated using CIE DE2000 formula. This paper proposed a new metric to measure the quality over all viewing angles. Results revealed that hue difference was useful in judgment of color shift and chroma difference was the key feature for evaluating color washout.
7.5L: Late‐News Paper: Developments of a 145‐inch Diagonal Super Hi‐Vision Plasma Display Panel
Authors: Ishii Keiji , Usui Takenobu , Murakami Yukio , Motoyama Yasushi , Seki Masahiko , Noguchi Yasuyuki , Furutani Takashi , Nakakita Tomoki , Yamashita Takeru 
Published: October 2012

AbstractWe have developed a prototype full‐resolution Super Hi‐Vision (SHV) plasma display panel (PDP) that has 4,320 scanning lines and over 33‐million pixels. Highly realistic SHV programs were the first successfully reproduced on a 145‐inch diagonal PDPs with a 0.417‐mm pixel pitch by applying a new panel driving method.
8.1: Invited Paper: A High‐Brightness Electrofluidic Display Film
Authors: Heikenfeld Jason , Hagedon Matt , Russell Ann , Yang Shu , Kreit Eric , Zhou Kaichang , Smith Steve , Atkuri Hari , Salem Lucy , Dean Kenneth , Rudolph John 
Published: October 2012

AbstractElectrofluidic displays operate by transposing a pigment between an optically hidden or revealed state. The transposition is powered by electromechanical force, and over similar distance switches ∼100X faster than electrophoresis by moving the pigment with the fluid, not through the fluid. We report on progress with our previously reported pixel structures, and on a new electrofluidic film that is the first of its kind for all fluidic displays (electrowetting, electrophoretic, electrokinetic, electrofluidic). The new structure operates without capsules or pixel walls for fluid confinement, and requires no pixel electrode alignment.
8.3: Transparent Silver Nanowire Film as Pixel Electrode for Flexible Electrophoretic Display
Authors: Tseng Shih‐Hao , Hung Shih‐Hsing , Hwu Keh‐Long , Hu Chih‐Jen , Huang Wei‐Ming 
Published: October 2012

AbstractIn this study, we clearly demonstrated a novel flexible conductor, silver nanowires (Ag NWs), to successfully achieve the pixel electrode pattern by using simple solution‐spin‐coating method followed by conventional photolithography process. Accordingly, both a 6″ SVGA active‐matrix flexible EPD and a 2″ passive‐matrix flexible E‐tag had successfully developed.
10.3: Polymerization Effect on Electro‐Optic Properties of Blue Phase Liquid Crystals
Authors: Zhu Ji‐Liang , Ni Shui‐Bin , Zhong En‐Wei , Lu Jian‐Gang , Su Yikai 
Published: October 2012

AbstractThe effect of polymerization on electro‐optic properties of blue phase liquid crystal (BPLC) is investigated. Once the monomer is added to the pure BPLC, chiral pitch and Kerr constant increase, but decay time decreases. In spite that the chiral pitch of polymer stabilized BPLC is almost no change after polymerization, Kerr constant decreases significantly and the decay time increases.
10.4: Aerosil Gels‐Dispersed Blue‐Phase Liquid Crystals: A New Technique to Control the Electro‐Optical Behavior of a Fast‐Switching Display
Authors: Hwang Jeoung‐Yeon , Chien Liang‐Chy 
Published: October 2012

AbstractThis study explores the roles of aerosil gels dispersed blue phase (AG‐d‐BP) liquid crystals and the influence on thermal, optical and electro‐optical behaviors of the resultant blue phase liquid crystal composites. Adding the aerosil nanoparticles in blue phase media leads to broadening the blue phase temperature range and reducing the switching voltage for a fast switching Kerr device. Additionally, the polarity‐controlled nanoparticles enable one to stabilize the thermal‐sensitive Bragg reflection property which opens pathways for applications such as active transformation optical elements and low power consumption displays.
11.1: Video‐Wall Matrix of Stereoscopic Displays using FPR
Authors: Abileah Adi , Dixon John 
Published: October 2012

AbstractWe built a video wall matrix of stereoscopic displays using film patterned retarder (FPR). We developed a model to calculate the vertical angular behavior of the FPR structure and compared it with conoscopic measurements. A second model developed to calculate viewing arena of stereo video walls with acceptable 3D crosstalk.
11.2: Fast Ferroelectric Liquid Crystal Modes for Field ‐Sequential‐ Color and 3D Displays
Authors: Chigrinov Vladimir , Pozhidaev Eugene , Srivastava Abhishek , Qi Guo , Kwok Hoi Sing 
Published: October 2012

AbstractThe development of novel photoaligned fast ferroelectric LCD based on Deformed Helix Ferroelectric (DHF) and Electrically Suppressed Helix (ESH) mode is discussed. A high quality dark state of DHF FLCD has been obtained as well as V‐shape switching with a high frequency. A fast response time and a high contrast ratio in ESH mode was observed. The applications in Field Sequential Color (FSC) and 3D LCD are envisaged.
12.2: Characterization of 3D Gray‐to‐Gray Crosstalk with a Matrix of Lightness Differences
Authors: Van Parys Hans , Teunissen Kees , Ševo Aleksandar 
Published: October 2012

AbstractStereoscopic televisions, mainly striped retarder displays with passive glasses and time‐sequential displays with active glasses, are emerging in the consumer market. 3D crosstalk is an important characteristic that defines the quality of these displays. As opposed to characterizing 3D crosstalk with one percentage value, we propose an intuitive matrix representation with perceptually relevant lightness‐difference values.
12.4: Novel Evaluation Method of 3D Color Crosstalk for Stereoscopic Displays
Authors: Park Sunhee , Lee Don Gyou , Lim Kyong Ho , Kim Jae Hong , Shin Hong Soep , Park Jongjin , Shin Hyun‐Ho 
Published: October 2012

AbstractAs the recent development of stereoscopic display, 3D image quality, especially for 3D crosstalk, has been extensively studied. Approach to 3D color crosstalk, however, is insufficient although most 3D contents consist of color images. This paper, therefore, describes novel evaluation method for 3D crosstalk in terms of color distortion, and presents results from primary, memory and gray color. Our studies will contribute to the understanding and improvement of 3D image quality.
13.1: Invited Paper: Carbonation Reaction of (Ca, Mg)O Protective Layer on PDP
Authors: Motoyama Yasushi , Kato Daisuke , Seki Masahiko 
Published: October 2012

AbstractWe have been applying a low discharge voltage (Ca, Mg)O protective layer to plasma display panels (PDPs) to reduce their power consumption. However, (Ca, Mg)O is highly reactive with CO2, and the resulting carbonate formation during high‐temperature panel sealing in air impairs the low discharge voltage characteristic. We investigated the mechanism of the carbonation reaction that occurs on a (Ca, Mg)O surface during annealing in air at 450°C and found that the CO2 diffuses through the formed CaCO3 layer and that a (Ca, Mg)O + CO2 r̊ CaCO3 + MgO reaction then occurs. This carbonation reaction evidently stops when the growing MgO finally forms a layer at all boundaries between the CaCO3 and (Ca, Mg)O regions.
13.3: CaMgO(CMO) Film Properties Study
Authors: Xing Fangli , Xue Daoqi , Lu Zhengxian , Luo Xianghui , Ji Nan , Yan Qun 
Published: October 2012

AbstractWe have investigated CaMgO(CMO) film by E‐beam(EB) and plasma gun(PG). By varying different deposition conditions, film show difference in contamination level, structure and discharge voltage characteristic. The film analysis is critical to develop manufacture process for high efficiency PDP with CMO.
13.5L: Late‐News Paper: Development of MgCaO Protective Layer of Plasma Display Panels for Decreased Discharge Voltage
Authors: Zukawa Takehiro , Yoshino Kyohei , Oe Yoshinao , Kawarazaki Hideji , Aoto Koji , Tanaka Yoshito , Murai Ryuichi 
Published: October 2012

AbstractPlasma display panels (PDPs) with an MgCaO protective layer and a new manufacturing process were achieved, with discharge voltage decreased while productivity was maintained. The evaporation rate of MgCaO became lower with the increasing Ca content, decreased by 20% at Ca 8 wt%. However, by changing several settings of evaporation, the evaporation rate of the Ca 8 wt% was improved to be comparable to that of MgO. The PDP with the Ca 8 wt% MgCaO protective layer decreased the discharge voltage by 12 V compared to that with the MgO protective layer. The life characteristics of the PDP with the MgCaO protective layer were the same as those with the MgO protective layer.
14.2: New Transparent Electrodes for Cholesteric Liquid Crystal Displays
Authors: Pellerite Mark J. , Baetzold John P. , Boulos Marie A. , Campbell Patrick M. , Haus Eileen M. , Hite Amy J. , Nirmal Manoj , Radcliffe Marc D. , Roberts Ralph R. , Stradinger John J. , Wardhana Jane K. , Weber Brian T. 
Published: October 2012

AbstractCholesteric liquid crystals are an important class of optical materials for bistable full‐color reflective displays. ITO and PEDOT are commonly used for transparent electrodes in ChLCD constructions. Both have limitations. Recent 3M work has shed light on new transparent electrodes for ChLCD displays that can give higher performing devices.
14.3: Patterned Image Flexible Reflex Displays
Authors: Montbach Erica , Krinock John , Chiu Joanna , Braganza Clinton , Schlemmer Matthew , Pishnyak Oleg , Marhefka Duane , Khan Asad , Doane J. William 
Published: October 2012

AbstractFlexible Reflex™ electronic skin and writing tablet displays can be patterned with translucent or opaque ink images for dynamic device case covers and tablets providing the user with new functionality and personalization. These displays result in complex images and multiple colors per display image at a low cost due to unpatterned conductors.