bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urethral dilatation: Is there any benefit over cystoscopy and distension? A randomized trial in women with overactive bladder symptoms
Authors: Basu Maya , Khullar Vik , Duckett Jonathan 
Published: May 2013

AbstractAimTo evaluate the effect of urethral dilatation (UD) on urgency symptoms in women with overactive bladder (OAB) and voiding dysfunction.MethodsWomen with OAB symptoms and a maximum flow rate of less than 15 ml/sec on a volume voided of 200 ml were eligible for entry to the trial. Fifty women with OAB symptoms and a maximum flow rate of less than 15 ml/sec on a volume voided of over 200 ml were randomized to undergo UD plus cystoscopy or cystoscopy alone. All subjects underwent filling and voiding cystometry pre‐operatively and at 6 weeks' post‐operatively. Subjective outcomes were assessed using the Urgency Perception Scale (UPS) and King's Health Questionnaire at baseline, 6 weeks and 6 months. The primary outcome measure was cure of urgency, defined using the UPS.ResultsUrgency was cured in 10/22 (45%) patients in the UD group and 5/28 (18%) in the non‐UD group at 6 weeks (Odds ratio 3.8, 95% confidence interval 1.1–13.8, P = 0.03). Cystometric flow data were available for all patients pre‐ and post‐UD. UD was associated with a significant increase in the flow rate centile from 1.66 to 8.54 (P = 0.01). At 6 months there was no benefit from UD with 4/22 in the UD group cured of urgency and 4/28 in the non‐UD group cured (Odds ratio 1.3, 95% confidence interval 0.3–6.1, P = 0.50).ConclusionUD confers a significant short‐term benefit in cure of urgency over cystoscopy alone, but there is no significant benefit in symptom relief in the long term. Neurourol. Urodynam. 33:283–288, 2014. © 2013 Wiley Periodicals, Inc.
An efficient 3D implicit approach for the thermomechanical simulation of elastic–viscoplastic materials submitted to high strain rate and damage
Authors: Jeunechamps P.‐P. , Ponthot J.‐P. 
Published: May 2013

SUMMARYThis paper aims at presenting a general consistent numerical formulation able to take into account, in a coupled way, strain rate, thermal and damage effects on the behavior of materials submitted to quasistatic or dynamic loading conditions in a large deformation context. The main features of this algorithmic treatment are as follows:

A unified treatment for the analysis and implicit time integration of thermo‐elasto‐viscoplastic constitutive equations including damage that depends on the strain rate for dynamic loading conditions. This formalism enables us to use dynamic thermomechanically coupled damage laws in an implicit framework.
An implicit framework developed for time integration of the equations of motion. An efficient staggered solution procedure has been elaborated and implemented so that the inertia and heat conduction effects can be properly treated.
An operator split‐based implementation, accompanied by a unified method to analytically evaluate the consistent tangent operator for the (implicit) coupled damage–thermo‐elasto‐viscoplastic problem.
The possibility to couple any hardening law, including rate‐dependent models, with any damage model that fits into the present framework.All the developments have been considered in the framework of an implicit finite element code adapted to large strain problems. The numerical model will be illustrated by several applications issued from the impact and metal‐forming domains. All these physical phenomena have been included into an oriented object finite element code (implemented at LTAS‐MN 2L, University of Liège, Belgium) named Metafor.Copyright © 2013 John Wiley & Sons, Ltd.
Towards verification of computation orchestration
Authors: Dong Jin Song , Liu Yang , Sun Jun , Zhang Xian 
Published: May 2013

Abstract

Recently, a promising programming model called
Orc
has been proposed to support a structured way of orchestrating distributed Web Services. Orc is intuitive because it offers concise constructors to manage concurrent communication, time-outs, priorities, failure of Web Services or communication and so forth. The semantics of Orc is precisely defined. However, there is no
automatic
verification tool available to verify critical properties against Orc programs. Our goal is to verify the orchestration programs (written in Orc language) which invoke web services to achieve certain goals. To investigate this problem and build useful tools, we explore in two directions. Firstly, we define a Timed Automata semantics for the Orc language, which we prove is semantically equivalent to the operational semantics of Orc. Consequently, Timed Automata models are systematically constructed from Orc programs. The practical implication is that existing tool supports for Timed Automata, e.g., Uppaal, can be used to simulate and model check Orc programs. An experimental tool has been implemented to automate this approach. Secondly, we start with encoding the operational semantics of Orc language in Constraint Logic Programming (CLP), which allows a systematic translation from Orc to CLP. Powerful constraint solvers like CLP are then used to prove traditional safety properties and beyond, e.g., reachability, deadlock-freeness, lower or upper bound of a time interval, etc. Counterexamples are generated when properties are not satisfied. Furthermore, the stepwise execution traces can be automatically generated as the simulation steps. The two different approaches give an insight into the verification problem of Web Service orchestration. The Timed Automata approach has its merits in visualized simulation and efficient verification supported by the well developed tools. On the other hand, the CPL approach gives better expressiveness in both modeling and verification. The two approaches complement each other, which gives a complete solution for the simulation and verification of Computation Orchestration.
Probabilistic illumination-aware filtering for Monte Carlo rendering
Authors: Doidge Ian C. , Jones Mark W. 
Published: May 2013

Abstract
Noise removal for Monte Carlo global illumination rendering is a well known problem, and has seen significant attention from image-based filtering methods. However, many state of the art methods breakdown in the presence of high frequency features, complex lighting and materials. In this work we present a probabilistic image based noise removal and irradiance filtering framework that preserves this high frequency detail such as hard shadows and glossy reflections, and imposes no restrictions on the characteristics of the light transport or materials. We maintain per-pixel clusters of the path traced samples and, using statistics from these clusters, derive an illumination aware filtering scheme based on the discrete Poisson probability distribution. Furthermore, we filter the incident radiance of the samples, allowing us to preserve and filter across high frequency and complex textures without limiting the effectiveness of the filter.
Early cardiovascular remodelling in Fabry disease
Authors: Costanzo Luca , Buccheri Sergio , Capranzano Piera , Di Pino Luigi , Curatolo Giuseppina , Rodolico Margherita , Leggio Stefano , Blundo Anita , Tamburino Corrado , Monte Ines 
Published: May 2013

AbstractAimsFabry disease (FD) is a rare X‐linked genetic disorder caused by the deficiency or absent activity of lysosomal α‐galactosidase A. Cardiovascular remodelling is a hallmark of FD. The present study aimed to comprehensively evaluate the cardiac, vascular and microvascular status in a population of patients with genetic mutations for FD without left ventricular hypertrophy (LVH).Methods and resultsThis study includes subjects carrying genetic mutations for FD (Fabry disease mutation‐carrier, FDMC) without LVH (n = 19). A group of control subjects (n = 19) matched for age, sex, body mass index and cardiovascular risk factors were also included. All subjects underwent echocardiography, carotid ultrasound scan, endothelial flow‐mediated dilatation (FMD) and nailfold capillaroscopy (NFC) assessment. When compared to the subjects in the control group, FDMC patients showed significantly lower mean values of systolic myocardial velocity (7.33 ± 1.28 vs. 10.08 ± 1.63 cm/s, p < 0.0001), longitudinal systolic strain (−18.07 ± 1.72 vs. −21.15 ± 2.22 %, p < 0.0001), significantly higher E/E’ mean values (7.15 ± 1.54 vs. 5.98 ± 1.27, p = 0.016) and intima‐media thickness mean values (0.80 ± 0.20 vs. 0.61 ± 0.19 mm, p = 0.005), significantly lower FMD (8.3 ± 4.6 vs. 12.2 ± 5.0 %, p = 0.02), more atypical capillaries and irregular NFC architecture in FDMC than control subjects (52.6 vs. 0 %, p < 0.0001; 78.9 vs. 36.8 %, p = 0.02 respectively).ConclusionsFD progressively involves cardiac, macrovascular and microvascular systems in an early stage. These features are present even in asymptomatic mutation carriers without LVH.
Velocity of Ground Water Percolation at Indaram, Godavari Sub-Basin, India
Authors: Gupta Mohan L. , Sharma S. R. 
Published: May 2013

Abstract
We present values of velocity of ground water percolation (Vg) over large depth intervals, varying from shallow to deeper depths in Indaram area of Godavari sub-basin. The velocities have been estimated using available measured geothermal data. Sub-surface temperatures were measured in seven boreholes. Terrestrial heat flow values are calculated using temperature data and measured values of thermal conductivity of core samples. The results show that Vg is ~3.4 x10−7 cm/sec in the top layers (70-150 m) and decreases to ~0.04x 10−7 cm/sec in the deeper levels around 350 m depth and becomes negligibly small thereafter, thereby, indicating that the overall permeability of the sub-surface layers, due to the occurrence of successions of permeable, semi-permeable layers gets reduced to more or less zero at depths around 350 m. The value of Thermal Peclet Number, which is the ratio of the heat transfer through convection to that through conduction, naturally becomes negligible around this depth in the area. The observed consistency of the magnitude of heat flow through various deep sections is a clear indicator that water percolation is practically reduced to zero at depths around 320-400 m and that conduction is the dominant mechanism of heat transfer below the inferred depth section, while the upper layers are dominated by recharge at various depths by near surface water from streams at Indaram.
First Report of Ranikothalia Caudri from Middle Andaman Island, India and its Significance
Authors: Koley Tarun , Wanjarwadkar K. M. 
Published: May 2013

Abstract
Genus Ranikothalia Caudri is described for the first time from the Upper Palaeocene sediments of Middle Andaman Island. Three species R. sidensis, R. cf. nuttalli, R. cf. tobleri along with one species of Discocyclina are described here. The occurrence of Ranikothalia has great implication in understanding the stratigraphy of the island and in deciphering the palaeogeography of the area. This point to the extension of the Ranikot Sea at least up to Middle Andaman.
Hydrocarbon of Source Rocks Evaluation Study of Lokichar Basin, Northwestern Kenya
Authors: Rop B. K. , Patwardhan A. M. 
Published: May 2013

Abstract:
The hydrocarbon potential of the sub-surface Tertiary sedimentary rock sequences of the Lokichar basin system (NW-Kenya) has been interpreted using some selective geochemical analysis of rock samples in Loperot-1 Well (denoted as LT-1 Well) for their total organic carbon (TOC) which forms the premise of this study. Understanding the sub-surface structures and depositional environments conducive for hydrocarbon generation and trapping is essential as it forms the basis for exploration. The organic matter richness and degree of thermal alteration and/or maturation are factors useful in evaluating the potential source rocks. Rock-Eval pyrolysis has been employed on selected rock samples with high TOC for quantification of data and this would help in precise identification of phases of hydrocarbon generation.
Stagnation Point Flow of Burgers' Fluid and Mass Transfer with Chemical Reaction and Porosity
Authors: Alsaedi A. , Alsaadi F. E. , Ali S. , Hayat T. 
Published: May 2013

AbstractThis paper studies the influence of mass transfer in the magnetohydrodynamic (MHD) boundary layer stagnation point flow of Burgers' fluid over a shrinking sheet. Analysis has been carried out in the presence of first order chemical reaction. The two-dimensional flow equations are modeled and then simplified using boundary layer approach. Similarity variables are used to transform the partial differential equations into nonlinear ordinary differential equation. The resulting system is computed using homotopy analysis method (HAM). It is noted that retardation time in Burgers' fluid enhances the magnitude of the flow. The gradient of mass transfer and surface mass transfer for various interesting parameters are also tabulated and analyzed.
Mixed Convection Flow of a Micropolar Fluid Past a Vertical Stretching Surface in a Thermally Stratified Porous Medium with Thermal Radiation
Authors: Mahmoud Mostafa A.A. , Waheed Shimaa E. 
Published: May 2013

AbstractThis paper is concerned with the effect of thermally stratification on the steady, two-dimensional mixed convection flow of a micropolar fluid past a vertical stretching permeable surface saturated in porous medium taking into account the effect of thermal radiation. The governing system of partial differential equations describing the problem are converted into a system of non-linear ordinary differential equations using similarity transformation. The resulting system of coupled nonlinear ordinary differential equations is solved numerically using the Chebyshev spectral method. The numerical results for the velocity, the micro-rotation and the temperature are displayed graphically showing the effects of various parameters like the buoyancy parameter, the radiation parameter, the stratification parameter, the permeability parameter and the suction/injection parameter. Moreover, the numerical values of the local skinfriction coefficient, the wall couple stress and the local Nusselt number for these parameters are also tabulated and discussed.
Using Fictitious Time Integration Method to Study Wave Propagation Over Arbitrary Bathymetry
Authors: Chang J.-Y. , Tsai C.-C. , Hsu T.-W. 
Published: May 2013

AbstractIn this study, the fictitious time integration method (FTIM) is applied to investigate wave propagation over an arbitrary bathymetry with measured uncertainty. The FTIM is used to convert the higher-order elliptic mild-slope equation (EMSE) into a FTIM like EMSE (FTIMEMSE). It has the advantage to describe wave transformation from deep water to shallow water region in a large coastal area with numerical efficiency. The validity of the noise resistance for the measured uncertainty of the bathymetry is also studied. In addition, typical examples for waves propagating over an elliptic shoal rest on a horizontal and sloping bottom is presented. It is concluded that the FTIM is robust in the numerical stability and capable of against the noise of the measurement.
Transient self-focusing of an intense laser pulse in magnetized plasmas under non-paraxial approximation
Authors: Gupta D.N. , Avinash K. , Suk H. 
Published: May 2013

AbstractNon-paraxial approximation based study of transient self-focusing of an intense short-pulse laser in plasma has been investigated by considering the effect of a transverse magnetic field. The laser with non-uniform distribution of intensity exerts a ponderomotive force on electrons and sets in an ambi-polar diffusion of the plasma. The ambient magnetic field, however, strongly inhibits the process, when the electron Larmor radius is comparable to or shorter than the laser spot size. As the plasma density is depleted, the laser beam becomes more self-focused. This study addresses a significant enhancement in the laser self-focusing rate by including the correction terms due the off-axis approximation.
Fetuin-A mRNA expression is elevated in NASH compared with NAFL patients
Authors: Kahraman Alisan , Sowa Jan-Peter , Schlattjan Martin , Sydor Svenja , Pronadl Martin , Wree Alexander , Beilfuss Anja , Kilicarslan Alpaslan , Altinbaş Akif , Bechmann Lars Peter , Syn Wing-Kin , Gerken Guido , Canbay Ali 
Published: May 2013

Fetuin-A is a pro-inflammatory protein expressed by hepatocytes. Its course in morbidly obese patients with NAFLD (non-alcoholic fatty liver disease) following weight loss by BAS (bariatric surgery) has not been fully elucidated yet. In the present study, we prospectively examined the effects of weight loss on various metabolic factors at 4 weeks and 6 months after surgery. Blood and liver tissues were retrieved from 108 morbidly obese NAFLD patients before/during BAS, and 50 of these individuals met the criteria for NASH (non-alcoholic steatohepatitis). Fetuin-A expression was measured by qPCR (quantitative real-time PCR), Western blotting and immunohistochemistry. Hepatocyte apoptosis was quantified via M30 (caspase-cleaved cytokeratin-18 fragments). Plasma concentrations of adiponectin and fetuin-A were determined by ELISA. Serum-derived parameters were additionally taken at 4 weeks and 6 months post-operatively. In addition, primary human hepatocytes were treated with NEFA (non-esterified fatty acid) to investigate changes in fetuin-A. BMI (body mass index) decreased significantly from 53.0±1.1 to 36.4±1.9 kg/m2 in the NAFL group and from 53.3±1.1 to 37.6±1.2 kg/m2 in the NASH group (P&lt;0.0001) at 6 months post-surgery. This was associated with diminishing M30 and M65 (total cytokeratin-18) levels over 6 months after surgery. Adiponectin levels increased continuously in NASH patients, whereas NAFL patients plateaued at 4 weeks post-operatively. Hepatic fetuin-A mRNA and protein expression was elevated before surgery-induced weight loss. However, plasma concentrations of fetuin-A increased signficantly in NASH patients 4 weeks post-operatively. Treatment of hepatocytes with NEFA led to up-regulation of fetuin-A expression. BAS probably has a beneficial effect on NAFLD, as indicated by reduced hepatocyte apoptosis and improved adipokine profiles. In addition, fetuin-A expression is more prominent in NASH.
Classification Accuracy of Nonword Repetition When Used With Preschool-Age Spanish-Speaking Children
Authors: Guiberson Mark , Rodríguez Barbara L. 
Published: May 2013

Purpose
The purpose of the present study was to (a) describe and compare the nonword repetition (NWR) performance of preschool-age Spanish-speaking children (3- to 5-year-olds) with and without language impairment (LI) across 2 scoring approaches and (b) to contrast the classification accuracy of a Spanish NWR task when item-level and percentage of phonemes correct (PPC) scoring methods are applied.

Method
Forty-four Spanish-speaking children participated. Twenty-one children had LI and 23 had typically developing (TD) language. Children were administered a Spanish NWR task and a standardized Spanish language measure.

Results
A developmental pattern in NWR performance was observed, and the children with LI had NWR scores that were significantly lower than those of the TD children. Whereas item-level scoring of NWR items indicated acceptable levels of sensitivity and specificity and suggested positive and negative likelihood ratios, PPC scoring of NWR items resulted in less than desirable levels of sensitivity and adequate specificity.

Conclusion
Item-level scoring of 3- to 5-syllable Spanish NWR items may be useful as part of an assessment battery for preschool-age Spanish-speaking children.
Utility of Stereolithographic Models in Osteocutaneous Free Flap Reconstruction of the Head and Neck
Authors: Morris L. , Sokoya Mofiyinfolu , Cunningham Larry , Gal Thomas J. 
Published: May 2013

Background Stereolithographic (SLA) models have become a valuable resource in preoperative planning in maxillofacial reconstruction. The objective of this study was to perform a defect specific analysis of the utility of SLA models. The goal was to determine the manner in which the perceived benefit of preoperative modeling translates to measurable clinical advantages. Methods Patients who underwent reconstruction of defects of the mandible or midface using SLA modeling between 2006 and 2011 were identified through billing records. Based on the nature and extent of bony defect, cases requiring nearly identical reconstruction, but without modeling, were matched case by case for comparison. Given the presumed efficiency of SLA modeling, a comparison of total and reconstructive operative times was performed to see if this could offset the cost of the model. Results There were 10 patients each in the “model” and “nonmodel” group. No significant differences were observed for total operative time between groups. Surprisingly, the total reconstructive time was lower in the group not using SLA models ( p = 0.05). Conclusions SLA models provide several operative planning advantages, but did not appear to decrease operative time enough to sufficiently offset the cost of the model in this group.
Juvenile hormone and its receptor, methoprene-tolerant, control the dynamics of mosquito gene expression
Authors: Zou Zhen , Saha Tusar T. , Roy Sourav , Shin Sang Woon , Backman Tyler W. H. , Girke Thomas , White Kevin P. , Raikhel Alexander S. 
Published: May 2013

SignificanceMosquitoes transmit some of the most dangerous human diseases. Microarray analysis of developmental gene dynamics in the femaleAedes aegyptifat body has demonstrated that 6,146 genes are differentially expressed during juvenile hormone-dependent posteclosion development. These genes show striking temporal and functional separation. A RNAi microarray screen revealed a differential action of Met in the down- and up-regulation of genes expressed during early and late PE, respectively. Thus, this study provides substantial evidence of a central role for insect-specific JH and its receptor Met in the regulation of female mosquito reproductive biology.
EMBRYONIC FLOWER1 and ULTRAPETALA1 Act Antagonistically on Arabidopsis Development and Stress Response
Authors: Pu Li , Liu Mao-Sen , Kim Sang Yeol , Chen Long-Fang O. , Fletcher Jennifer C. , Sung Zinmay Renee 
Published: May 2013

AbstractEpigenetic regulation of gene expression is of fundamental importance for eukaryotic development. EMBRYONIC FLOWER1 (EMF1) is a plant-specific gene that participates in Polycomb group-mediated transcriptional repression of target genes such as the flower MADS box genes AGAMOUS, APETALA3, and PISTILLATA. Here, we investigated the molecular mechanism underlying the curly leaf and early flowering phenotypes caused by reducing EMF1 activity in the leaf primordia of LFYasEMF1 transgenic plants and propose a combined effect of multiple flower MADS box gene activities on these phenotypes. ULTRAPETALA1 (ULT1) functions as a trithorax group factor that counteracts Polycomb group action in Arabidopsis (Arabidopsis thaliana). Removing ULT1 activity rescues both the abnormal developmental phenotypes and most of the misregulated gene expression of LFYasEMF1 plants. Reducing EMF1 activity increases salt tolerance, an effect that is diminished by introducing the ult1-3 mutation into the LFYasEMF1 background. EMF1 is required for trimethylating lysine-27 on histone 3 (H3K27me3), and ULT1 associates with ARABIDOPSIS TRITHORAX1 (ATX1) for trimethylating lysine-3 on histone 4 (H3K4me3) at flower MADS box gene loci. Reducing EMF1 activity decreases H3K27me3 marks and increases H3K4me3 marks on target gene loci. Removing ULT1 activity has the opposite effect on the two histone marks. Removing both gene activities restores the active and repressive marks to near wild-type levels. Thus, ULT1 acts as an antirepressor that counteracts EMF1 action through modulation of histone marks on target genes. Our analysis indicates that, instead of acting as off and on switches, EMF1 and ULT1 mediate histone mark deposition and modulate transcriptional activities of the target genes.