bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of a sleep-disordered breathing screening questionnaire during pregnancy and comparison between mothers and bedpartners prediction of risk
Authors: Booker Lauren A. , Howard Mark E. , Walker Susan P. , Wilson Danielle L. 
Published: August 2024

Abstract
Background
Sleep Disordered Breathing (SDB) in pregnant patients ranges from 3 to 27% and varies depending on gestational age and method used to diagnose. SDB increases the risk of advanced pregnancy complications such as gestational diabetes mellitus, pregnancy-induced hypertension, and preeclampsia. Screening and diagnosis of SDB during pregnancy remains a challenge, with existing screening tools underperforming during pregnancy. This study aimed to validate a previously developed model for predicting SDB during late pregnancy and compare the predictive value of bedpartner responses.

Methods
Ninety-six women in the third trimester of pregnancy underwent polysomnography and completed the Berlin Questionnaire (BQ), with 81 bedpartners completing the BQ about their pregnant partner. A subset of BQ items (snoring volume and tiredness upon awakening) along with BMI > 32 kg/m2was utilised to calculate the Wilson Optimized Model (WOM), which demonstrated strong predictive properties in development.

Results
SDB (RDI/hr ≥ 5) was detected in 43.8% of women. BQ identified 72% of pregnant mothers as high risk for SDB (Sensitivity = 83%, Specificity = 37%), compared to 29% of mothers identified by the WOM (Sensitivity = 45%, Specificity = 83%). At RDI of ≥ 15, the WOM correctly classified more women according to SDB risk than the BQ (76.0% vs. 41.7% cases correct,X2(1) = 23.42,p < .001), with no difference at RDI ≥ 5. Bedpartners were more likely to report high risk for SDB on the WOM than pregnant women themselves (38.3% vs. 28.4%), however predictive ability was not improved by bedpartner input (RDI ≥ 5 bedpartner AUC = 0.69 v mother AUC = 0.73).

Conclusion
BQ largely overestimates the prevalence of SDB in pregnancy compared to the WOM which underestimates. Utilising bedpartner responses didn’t improve screening for SDB in late pregnancy. More work is needed to develop a pregnancy-specific tool for quick and accurate screening for SDB.
The PROgnostic ModEl for chronic lung disease (PRO-MEL): development and temporal validation
Authors: Ng Sheryl Hui-Xian , Chiam Zi Yan , Chai Gin Tsen , Kaur Palvinder , Yip Wan Fen , Low Zhi Jun , Chu Jermain , Tey Lee Hung , Neo Han Yee , Tan Woan Shin , Hum Allyn 
Published: August 2024

Abstract
Background
Patients with chronic lung diseases (CLDs), defined as progressive and life-limiting respiratory conditions, experience a heavy symptom burden as the conditions become more advanced, but palliative referral rates are low and late. Prognostic tools can help clinicians identify CLD patients at high risk of deterioration for needs assessments and referral to palliative care. As current prognostic tools may not generalize well across all CLD conditions, we aim to develop and validate a general model to predict one-year mortality in patients presenting with any CLD.

Methods
A retrospective cohort study of patients with a CLD diagnosis at a public hospital from July 2016 to October 2017 was conducted. The outcome of interest was all-cause mortality within one-year of diagnosis. Potential prognostic factors were identified from reviews of prognostic studies in CLD, and data was extracted from electronic medical records. Missing data was imputed using multiple imputation by chained equations. Logistic regression models were developed using variable selection methods and validated in patients seen from January 2018 to December 2019. Discriminative ability, calibration and clinical usefulness of the model was assessed. Model coefficients and performance were pooled across all imputed datasets and reported.

Results
Of the 1000 patients, 122 (12.2%) died within one year. Patients had chronic obstructive pulmonary disease or emphysema (55%), bronchiectasis (38%), interstitial lung diseases (12%), or multiple diagnoses (6%). The model selected through forward stepwise variable selection had the highest AUC (0.77 (0.72–0.82)) and consisted of ten prognostic factors. The model AUC for the validation cohort was 0.75 (0.70, 0.81), and the calibration intercept and slope were − 0.14 (-0.54, 0.26) and 0.74 (0.53, 0.95) respectively. Classifying patients with a predicted risk of death exceeding 0.30 as high risk, the model would correctly identify 3 out 10 decedents and 9 of 10 survivors.

Conclusions
We developed and validated a prognostic model for one-year mortality in patients with CLD using routinely available administrative data. The model will support clinicians in identifying patients across various CLD etiologies who are at risk of deterioration for a basic palliative care assessment to identify unmet needs and trigger an early referral to palliative medicine.

Trial registration
Not applicable (retrospective study).
Effect of Advanced Footwear Technology Spikes on Sprint Acceleration: A Multiple N-of-1 Trial
Authors: Bernuz Benjamin , Laujac Steven , Sirial Cedric , Auffret Stephane , Preda Cristian , Slawinski Jean , Millot Benjamin , Pradon Didier , Coudrat Laure , Gavarry Olivier 
Published: August 2024

Abstract
Background
In contrast with Advanced Footwear Technology-AFT running shoes for long-distance, little is known about AFT sprint spikes on performance and acceleration parameters. However, their use has become widespread since the Tokyo 2020 Olympics, and knowledge of their effects would seem to be an essential starting point before any clinical or socio-economic considerations.

Objectives
Our objectives were to determine intra- and inter-subject sprinting performance modifications with Nike® AFT spikes (NAS) compared to standard spiked-shoes (SS).

Methods
Healthy regional to national sprint athletes (n = 21, ≥ 750 pts World Athletics) performed 16 repetitions of 30-m sprints with either the NAS or SS condition during a single session, based on the multiple N-of-1 method, with pairwise randomisation and double-blind procedure. Time on 30-m sprints (Stalker radar), force-velocity profile (F0, V0, Vmax, Pmax, RF, DRF and FVP slope), and confounding factors (wind and shoe mass) were measured. Statistical analyses included a mixed linear regression model for group analyses, and randomisation test inversion and non-overlap-of-all-pair (NAP) methods for intra-individual analysis.

Results
NAS improved 30-m time by a mean of − 0.02 s (SMD = 0.4, p = 0.014), with no interaction with any confounding factors. Significant changes were seen in velocity (Vmax : SMD = 0.9, p < 0.001; V0: SMD = 0.7, p < 0.001) and the horizontal ratio of force (RFmax: SMD = 0.5, p = 0.043), with no changes observed in force production. Whatever the footwear, one unit of positive wind (+ 1 m.s− 1 ) improved performance by − 0.03 s (p < 0.001). At an individual level, four athletes improved (NAP ≥ 0.69), and one had a statistical decrease in performance. Changes in F-V profiles were largely individual.

Conclusions
A positive effect on sprint acceleration characteristics was observed when using Nike® AFT spikes, due to an increase in velocity and the horizontal ratio of force. A major variability in inter-individual response justifies single-case experimental designs for research on the topic.

Trial Registration Number
NCT05881148.
Iron therapy effect on chronic heart failure and iron-deficiency anemia: a systematic review and meta-analysis
Authors: Pintaningrum Yusra , Yunandari Ni Putu 
Published: August 2024

Abstract
Background
Heart failure complicated with iron deficiency is associated with impaired functional capacity, poor quality of life, increased hospitalization, and mortality. This systematic review and meta-analysis were conducted to assess the effect of oral and intravenous iron therapy on functional capacity, hospitalization risk, and mortality risk in patients with chronic heart failure and iron-deficiency anemia.

Methods
Search for published scientific articles using the PRISMA (Preferred Reporting, Items for Systematic Reviews and Meta-Analysis) method conducted on Cochrane Library, PubMed Central, and Medline databases published in the last 20 years. Further systematic review and meta-analysis using RevMan version 5.4 were performed based on the included published scientific articles.

Results
Based on the meta-analysis of included studies, the analytical results of intravenous iron therapy in patient with chronic heart failure and iron-deficiency anemia showed there is 30.82 (MD = 30.82: 95% CI 18.23–43.40) meter change in patient 6MWT, there is likelihood of 0.55 times (55%) (RR = 0.45: 95% CI 0.30–0.68) lower risk of hospitalization and lower risk of mortality (RR = 0.18: 95% CI 0.04–0.78), because heart failure worsening both with statistically significant overall effect compared with placebo.

Conclusions
There is statistically significant effect of intravenous iron therapy to improve patient functional capacity and reduce likelihood of hospitalization risk of 0.55 times (55%) in patient with chronic heart failure and iron-deficiency anemia.
Correlation between bruxism and cervical function
Authors: Elmesseh Olivia I. Abd , El-Sayyad Mohsen M. , Karkousha Rania N. 
Published: August 2024

Abstract
Background
Temporomandibular joint has biomechanical and neurological interactions with cervical region in a complex functioning that is addressed as cranio-cervical mandibular system.

Subjects and methods
In a prospective cohort study of 67 patients, their mean age 24.3 ± 5.6 years of both genders with temporomandibular disorder “bruxism,” patients had fulfilled a questionnaire regarding bruxism manifestations. Pain pressure algometer was used to assess pain pressure threshold for trigger point in masseter, temporalis, sternocleidomastoid, and trapezius, and bubble inclinometer was used to assess cervical proprioception for all cervical ranges.

Results
There was a statistical significant indirect weak correlation between proprioception error of cervical flexion and pain pressure threshold of masseter (r = − 0.333) (p = 0.006), between proprioception error of cervical flexion and pain pressure threshold of trapezius (r = − 0.363) (p = 0.003), and also between proprioception error of cervical left-side bending and pain pressure threshold of trapezius (r − 0.298; p 0.014), while there was significant direct weak correlation between proprioception error of cervical left rotation and cervical bending to left (r 0.315; p 0.009), where the p-value was < 0.05.

Conclusion
The study proved that temporomandibular joint pain was correlated with impaired neck proprioception in whom with bruxism.

Trial registration
NCT05657353. Registered 28 November 2022 — prospectively registered, https://register.clinicaltrials.gov/prs/app/action/LoginUser?ts=1&cx=-jg9qo4.
Increasing Power in Phase III Oncology Trials With Multivariable Regression: An Empirical Assessment of 535 Primary End Point Analyses
Authors: Sherry Alexander D. , Passy Adina H. , McCaw Zachary R. , Abi Jaoude Joseph , Lin Timothy A. , Kouzy Ramez , Miller Avital M. , Kupferman Gabrielle S. , Beck Esther J. , Msaouel Pavlos , Ludmir Ethan B. 
Published: August 2024

PURPOSE A previous study demonstrated that power against the (unobserved) true effect for the primary end point (PEP) of most phase III oncology trials is low, suggesting an increased risk of false-negative findings in the field of late-phase oncology. Fitting models with prognostic covariates is a potential solution to improve power; however, the extent to which trials leverage this approach, and its impact on trial interpretation at scale, is unknown. To that end, we hypothesized that phase III trials using multivariable PEP analyses are more likely to demonstrate superiority versus trials with univariable analyses. METHODS PEP analyses were reviewed from trials registered on ClinicalTrials.gov. Adjusted odds ratios (aORs) were calculated by logistic regressions. RESULTS Of the 535 trials enrolling 454,824 patients, 69% (n = 368) used a multivariable PEP analysis. Trials with multivariable PEP analyses were more likely to demonstrate PEP superiority (57% [209 of 368] v 42% [70 of 167]; aOR, 1.78 [95% CI, 1.18 to 2.72]; P = .007). Among trials with a multivariable PEP model, 16 conditioned on covariates and 352 stratified by covariates. However, 108 (35%) of 312 trials with stratified analyses lost power by categorizing a continuous variable, which was especially common among immunotherapy trials (aOR, 2.45 [95% CI, 1.23 to 4.92]; P = .01). CONCLUSION Trials increasing power by fitting multivariable models were more likely to demonstrate PEP superiority than trials with unadjusted analysis. Underutilization of conditioning models and empirical power loss associated with covariate categorization required by stratification were identified as barriers to power gains. These findings underscore the opportunity to increase power in phase III trials with conventional methodology and improve patient access to effective novel therapies.
End Point Surrogacy in First-Line Chronic Lymphocytic Leukemia
Authors: Simon Florian , Ligtvoet Rudy , Robrecht Sandra , Cramer Paula , Kutsch Nadine , Fürstenau Moritz , Goede Valentin , von Tresckow Julia , Langerbeins Petra , Fink Anna-Maria , Huber Henriette , Tausch Eugen , Schneider Christof , Wendtner Clemens M. , Ritgen Matthias , Dreyling Martin , Müller Lothar , Jacobasch Lutz , Heinz Werner J. , Vehling-Kaiser Ursula , Sivcheva Liliya , Böttcher Sebastian , Dreger Peter , Illmer Thomas , Gregor Michael , Staber Philipp B. , Stilgenbauer Stephan , Niemann Carsten U. , Kater Arnon P. , Fischer Kirsten , Eichhorst Barbara , Hallek Michael , Al-Sawaf Othman 
Published: August 2024

PURPOSE
Surrogate end points are commonly used to estimate treatment efficacy in clinical studies of chronic lymphocytic leukemia (CLL). This patient- and trial-level analysis describes the correlation between progression-free survival (PFS) and minimal residual disease (MRD) with overall survival (OS) in first-line trials for CLL.

PATIENTS AND METHODS
First, patient-level correlation was confirmed using source data from 12 frontline German CLL Study Group (GCLLSG)-trials. Additionally, a joint-frailty copula model was fitted to validate correlation in the setting of targeted therapies (TT). Second, a meta-analysis of first-line phase III trials in CLL from 2008 to 2024 was performed. Treatment effect correlation was quantified from seven GCLLSG and nine published trials, using hazard ratios (HRs) for time-to-event and odds ratios for binary end points.

RESULTS

The GCLLSG analysis set comprised 4,237 patients. Patient-level correlation for PFS/OS was strong with Spearman Rho >0.9. The joint-frailty copula indicated a weak correlation for chemotherapy/chemoimmunotherapy (C/CIT) with a tau of 0.52 (95% CI, 0.49 to 0.55) while the correlation was strong for TT (tau, 0.91 [95% CI, 0.89 to 0.93). The meta-analysis set contained a total of 8,065 patients including 5,198 (64%) patients treated with C/CIT and 2,867 (36%) treated with TT. Treatment-effect correlation of the HRs for PFS and OS was
R
= 0.75 (95% CI, 0.74 to 0.76,
R
2
= 0.56) while correlation of end-of-treatment MRD with PFS and OS was
R
= 0.88 (95% CI, –0.87 to 0.89;
R
2
= 0.78) and 0.71 (95% CI, 0.69 to 0.73;
R
2
= 0.5), respectively.

CONCLUSION
Patient-level correlation was confirmed in the setting of TTs while treatment-effect correlation between PFS and OS remains uncertain. MRD response status showed a high treatment-effect correlation with PFS but not OS, with the caveat of a limited number of randomized trials with available MRD data.
Preoperative Serum Lipids as Novel Predictors of Survival in 3575 Patients With Papillary Thyroid Cancer
Authors: Yuan Jimeng , Chen Zhendong , Zhang Jing , Chen Xianmeng , Chen Shitu , Wang Xumeng , Zhang Junbin , Su Xingyun , Zhu Weipu , Sheng Jinghao , Teng Lisong , Wang Weibin 
Published: August 2024

Abstract

Context
Papillary thyroid cancer (PTC) is an endocrine malignancy with rapidly increased rate. The relationship between lipids and PTC recurrence need further investigate.

Objective
The objective of this study is to investigate the association between preoperative serum lipids levels and the outcomes of PTC patients.

Methods
A retrospective cohort study including 3575 patients with PTC from 2012 to 2016 with follow-ups in our institute were enrolled. Preoperative serum lipids were divided into categorical variables by receiver operating curves. Univariable and multivariable Cox regression models were developed and independent risk factors were used to construct a nomogram to predict disease-free survival (DFS) rate.

Results
Among the 3575 patients, the mean follow-up time was 56.7 months. Comparing with the patients with high levels of triglyceride (TAG ≥ 0.605 mmol/L) and high-density lipoprotein (HDL ≥ 0.935 mmol/L), those with low levels of TAG (hazard ratio [HR] 2.20, 95% CI 1.30-3.72) and HDL (HR 1.60, 1.00-2.57) had a significantly higher risk of recurrence in PTCs. The 5-year DFS rate of patients with low levels of TAG was 94.4%, which was much lower than that in the high-level group (97.2%, P &lt; .001). While cholesterol (P = .13), low-density lipoprotein (P = .07), and very low–density lipoprotein (P = .15) were not statistically correlated with recurrence of PTCs. The nomogram model showed clinical predictive value with a c-index of 0.80 (95% CI 0.73-0.87) and 0.82 (95% CI 0.73-0.90) for 3- and 4-year DFS in the training cohorts.

Conclusion
In the present study, we provide initial evidence that low levels of TAG and HDL were independently associated with the recurrence of PTC, indicating that preoperative serum concentrations of lipids are helpful in predicting the prognosis for patients with PTC in clinical practice.
Stress Testing Spillover Risk in Mutual Funds
Authors: Capponi Agostino , Glasserman Paul , Weber Marko Hans 
Published: August 2024

We develop a framework to quantify the vulnerability of mutual funds to fire-sale spillover losses. We account for the first-mover incentive that results from the mismatch between the liquidity offered to redeeming investors and the liquidity of assets held by the funds. In our framework, the negative feedback loop between investors’ redemptions and price impact from asset sales leads to an aggregate change in funds’ net asset value, which is determined as a fixed point of a nonlinear mapping. We show that a higher concentration of first movers increases the aggregate vulnerability of the system as measured by the ratio between endogenous losses triggered by fund redemptions and exogenous losses caused by initial price shocks only. When calibrated to U.S. mutual funds, our model shows that, in stressed market scenarios, spillover losses are significantly amplified through a nonlinear response to initial shocks that results from the first-mover incentive. Higher spillover losses provide a stronger incentive to redeem early, further increasing fire-sale losses and the transmission of shocks through overlapping portfolio holdings. This paper was accepted by David Simchi-Levi, finance. Funding: The research of A. Capponi has been supported by the National Science Foundation–Civil Mechanical and Manufacturing Innovation) CAREER grant [Grant 1752326]. The research of M. H. Weber has been supported by the NUS Start-Up grant [Grant A-0004587-00-00] and the Singapore MOE Tier 1 grant [Grant A-8000966-00-00]. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.03443 .
Earnings Pressure and Corporate Social Responsibility Impression Management
Authors: Liu Chang , Zhao Xiaoping 
Published: August 2024

Extensive research has investigated the buffering effect of corporate social responsibility (CSR) when firms have poor financial performance. However, few studies have examined the possible consequences of this effect. By analyzing data on listed firms in China from 2010 to 2018, this study investigates the buffering effect of CSR under conditions of earnings pressure, and then discusses its impact on CSR disclosure impression management behavior. The results show that CSR can buffer the negative impact of earnings pressure on stock prices, chief executive officer stability, and top management team stability. This buffering effect is mainly exerted by technical CSR. Moreover, earnings pressure leads to CSR disclosure impression management without resulting in improved CSR performance. These findings have implications for cultivating CSR buffering awareness among firms and managers. The results also have practical implications for future research on the antecedents and motivations of CSR disclosure impression management. Funding: This work was supported by the National Natural Science Foundation of China [Grant 72372104].
EVALUATION OF PATIENT SAFETY STEPS IN GENERAL HOSPITAL OF YOGYAKARTA CITY (RSUD YOGYAKARTA CITY)
Authors: Apriyani Wilda , Sofiana Liena 
Published: August 2024

Background of Study: Patient Safety of hospital is a system where the hospital makes patient adoption safer. In giving a quality of guarantee provide health and patient safety, this hospital is applying patient safety program. The result of our acknowledgements show SOP that has not been working as accurately. At this incident should be told 2x24 hours maximal, sometime there is exceeding the line and it is not reported. The purpose of this project is to evaluate the step of patient's safety that has been applied at the inpatient installation in the regional hospital of Yogyakarta.Research Method : this research isÂ a qualitative research with case approach to 6 informan that used an interview guidance and check list which is refering to the minister of health on Patientâ€™s Safety. Analysis data used data reduction, data display and conclusion.The results of study: the result of this research showed six of seven steps of patient safety has been working with the rule of minister of health about of patient safety, althought in progressing need an increasing . However, your leaders and proponentsÂ has not been working with the rule of minister of health about of patient safety.Conclusion : this research is one of seven steps of patient safety, 6 steps has been working with the rule of minister of health about of patient safety.
The Relationship of the Clinical Practice Environment, Supervision and Supervisors with Students' Clinical Experience as an Effort to Prepare Professional Nurse Graduates
Authors: Susanti Devi , Herlitawati Herlitawati , Hidayat Taufik , Yusnaini Yusnaini 
Published: August 2024

Background: Learning turns theoretical knowledge into practice for nursing students. The quality of a student's clinical experience is influenced by the practice environment, supervision, and supervisor. The clinical practice environment influences the approach and achievement of student competencies. Supervision is important for quality nursing care, while effective supervisors act professionally and guide students in managing patients. This study aims to analyze the relationship between the clinical practice environment, supervision and supervisors with the clinical experience of students as an effort to prepare professional nurse graduates in the D-III Nursing study program in Kutacane, Poltekkes Kemenkes Aceh, totaling 64 students with a sampling technique, namely total sampling based on inclusive criteria. Methods: Type of research This is a correlational analytical descriptive with a cross sectional approach. Data analysis was carried out via Univariate and Bivariate. Results: The results of this research show that there is a significant relationship between the clinical practice environment, supervision and supervisors with the clinical experience of students in the D-III Nursing study program in Kutacane, Poltekkes Kemenkes Aceh with p-values of 0.033, 0.024 and 0.015. Conclusion: Therefore, it is recommended that collaboration between educational institutions and health institutions be strengthened to create an optimal clinical practice environment.