bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arteriovenous fistula aneurysms in patients with Alport's
Authors: Field Melanie A. , McGrogan Damian G. , Tullet Karen , Inston Nicholas G. 
Published: July 2013

Purpose Alport's syndrome is a rare but important cause of renal failure. It is characterized by Type IV collagen mutations resulting in connective tissue disorders and renal and cochlear dysfunction. Vascular basement membrane also contains collagen IV and the effect on arteriovenous fistulas (AVFs) is not reported. Anecdotally, we observed a high rate of aneurysm formation in Arteriovenous fistulas (AVF) of patients with Alport's and sought to determine whether this was the case within our population. Methods All patients with a diagnosis of Alport's were identified from a contemporaneously maintained database. AVFs formed in patients with Alport's were identified to define the incidence of aneurysms in this group. Results A total of 40 patients with a diagnosis of Alport's were identified. Of these, 20 patients had undergone AVF formation, the remainder opting for CAPD as renal replacement or had undergone pre-emptive transplantation. Of the 20 patients identified, 11 had an AVF and of these the rate of aneurysm formation was high (55%). Conclusions While this finding of high rate of aneurysmal AVF in Alport's patients is a purely observational finding within our population further population study would be extremely interesting and could support enhanced surveillance or alternative dialysis modalities in Alport's syndrome patients.
O recurso mais importante para as organizações são mesmo as pessoas? Uma análise da produção científica sobre qualidade de vida no trabalho (QVT)
Authors: Venson Aline Botelho Schneider , Fiates Gabriela Gonçalves Silveira , Dutra Ademar , Carneiro Marcelo Lopes , Martins Cristina 
Published: July 2013

DOI: 10.5902/198346595705 The discourse in organizations in general, regardless of size or nature, focuses on a recurring basis the relevance of human capital for success and direct relationship between employee performance and organizational results. Studies about quality of work life are extremely important to understand the variables that impact performance and results for both: the organization and its employees. To evaluate how scientific research reflect this importance, this study has been developed to analyze the scientific production on the subject of quality of work life - QWL in Brazil, analyzing the articles published in the annals of EnANPAD - Meeting of the National Association Postgraduate and Research in Administration. This is a bibliometric research of academic production in the period 1997 to 2011. After collection of information were found 64 articles that met at least one of keywords defined by the scope of this study. As a result it was found that the subject of quality of working life until 2008 was still discussed in scientific literature only incidentally, with an investigative nature, in order to diagnose only QVT index, without seeking to identify its impact on the organization as a whole. However, from 2009 it can already notice a maturity based on the identification of works that investigated the relationship between QWL, social responsibility, organizational commitment and, including, performance.
<b>A indisciplina na instituição escolar: o trabalho com assembleias de classe no desenvolvimento de crianças morais autônomas</b>
Authors: Dias Carmen Lúcia , Colombo Terezinha Ferreira da Silva 
Published: July 2013

http://dx.doi.org/10.5902/198464445062 Os problemas de indisciplina e violência nas escolas nas últimas décadas se configuram num dos principais desafios a preocupar educadores em diversos países. A indisciplina é, em parte, produzida pelas relações interpessoais e esta poderá ser superada com a promoção de um trabalho amplo relacionado aos aspectos sociais. No que tange à sala de aula algumas propostas de superação se apresentam: o self-government (autogoverno) e assembleias de classe. O objetivo do presente estudo é evidenciar a importância das assembléias de classe, visando a construção de sujeitos morais autônomos, através de relações de cooperação, reciprocidade e respeito mútuo, com a perspectiva de superação da indisciplina. A partir da descrição de situações vivenciadas no contexto escolar por crianças de sete e oito anos, pertencentes a uma escola de ensino fundamental, situada na periferia de uma cidade do interior paulista, procurou-se evidenciar tal importância por meio da análise do pensamento e do desenvolvimento da moralidade (DELVAL, 2002) deste grupo, envolvendo dilemas reais emergidos da convivência entre professor/aluno e aluno/aluno. A importância da utilização de recursos como as assembléias de sala de aula, fica evidenciada no presente estudo. Portanto, o espaço das assembléias de classe permite experiências conceituais concretas e práticas de democracia na escola, que poderão levar todos os membros da comunidade a vivenciarem um ambiente democrático e respeitoso, contribuindo para a educação e cidadania. Palavras-chave: indisciplina, assembléias de classe, ensino fundamental.
<b>Efeitos da racionalidade neoliberal nos discursos sobre inclusão: o silêncio docente</b.
Authors: Possa Leandra Boer , Naujorks Maria Inês 
Published: July 2013

http://dx.doi.org/10.5902/198464445926 Este texto tem como objetivo colocar em movimento analítico a Política Nacional de Educação Especial na Perspectiva da Educação Inclusiva, bem como os programas que acolhem a formação de professores para a diversidade/inclusão, disponíveis no site do Ministério da Educação, no que diz respeito a possíveis efeitos desses discursos. Não temos a pretensão de fazer uma análise exaustiva desses documentos, mas sim, problematizar um desses efeitos, que temos identificado como silenciamento docente, que esta política neoliberal vem produzindo nos últimos anos, no discurso dos professores que atuam nos sistemas de educação municipal e estadual da região de Santa Maria. Utilizamos nesse empreendimento a ferramenta conceitual-metodológica da governamentalidade, proposta por Michel Foucault, para pensarmos que os discursos sobre a inclusão capturam e, por isso, subjetivam os professores nessa nova ordem. Não há, portanto, espaço para contestação. Como efeito, temos o silêncio de um tipo de palavra e a captura dos professores em redes discursivas que operam na produção e no consumo do princípio da inclusão e no empreendimento de si, marcas desse nosso tempo.
<b>A utilização de charges e tiras humorísticas como recurso didático-pedagógico mobilizador no processo de ensino-aprendizagem da Geografia</b>
Authors: Alves Telma Lucia Bezerra , Pereira Suellen Silva , Cabral Laíse Do Nascimento 
Published: July 2013

http://dx.doi.org/10.5902/198464447915 O presente trabalho teve como objetivo avaliar a utilização de charges e tiras humorísticas como recurso didático inovador no processo de ensino-aprendizagem, visualizando uma renovação no ensino da geografia. No caso presente, foi dada ênfase a Geografia ambiental, correlacionando os conteúdos abordados em sala de aula com as imagens selecionadas. Para tanto foram realizadas pesquisas bibliográficas, bem como a pesquisa de campo, sendo esta realizada com discentes do Curso de Licenciatura Plena em Geografia de duas Instituições de Ensino Superior (IES), da cidade de Campina Grande-PB, utilizando-se como recursos metodológicos a análise crítica-reflexiva das representações gráficas supracitadas, bem como a transcrição das declarações dos discentes pesquisados, observando-se a capacidade de compreensão e interpretação dos atributos imagéticos, críticos, humorísticos e satíricos contidos nestas comunicações, caracterizadas também pela sua temporalidade. Foi possível concluir que o uso da charge e das tiras humorísticas em sala de aula é um recurso estratégico que pode ser utilizado pelos professores, não só na área da Geografia, mas também em outras disciplinas de outros componentes curriculares, promovendo ainda um exercício interdisciplinar. A charge e as tiras humorísticas apresentaram-se como potencialidades a serem exploradas pelos professores e disseminadas no âmbito educacional, pois além de despertar a curiosidade no estudante para entender as mensagens repassadas, faz com que este se interesse pelo conteúdo que está sendo transmitido e construído, promovendo-se, assim, uma renovação nas abordagens geográficas. Dessa forma o professor encontra mais facilidade de interagir com os alunos, promovendo a dinamização das aulas.
Alpha-Fetoprotein Producing Breast Cancer Cells: Case Report and Review of Literature
Authors: Asma Kassab  , Awatef Msolly  , Abdelhedi Miled  , Olfa Gharbi  
Published: July 2013

Abstract: Aim:In this paper we report a rare case of breast carcinoma followed by liver metastasis associated to alpha fetoprotein (AFP) secretion by tumor cells. Methods:Carcino-embryonic antigen (CEA), carbohydrate antigen (CA) 15-3, serum AFP and AFP immunohistochemistry staining were detectedusing commercial kits in 44 year-old woman with breast cancer. Results: CEA and CA 15-3 were within normal limits. AFP baseline was 14000 ng/l. There was no chronic hepatic viral disease. Biopsy revealed invasive carcinoma ductal cells. Histologic examination of the tumor showed invasive carcinoma, nuclear grade was 2, the tumour cells were negative for oestrogen and progesterone receptor positive for Her-2/neu. The immunohistochemistry stainig for AFP revealed positive reactivity. After chemotherapy, AFP level was within the normal rangeand abdominal ultrasonography showed a partial response evaluated at 50 %. The patient was in good condition at the time of our report (May 2013). Conclusion:We presume that the increased serum AFP level is responsible for the cancer evolution with good prognosis for breast cancer and poor one for gastric cancer and colon cancer.
TRAP1 is Involved in Cell Cycle Regulated by Retinoblastoma Susceptibility Gene (RB1) in Early Hypoxia and has Variable Expression Patterns in Human Tumors
Authors: Jiangting Hu  , Ern Yu Tan  , Leticia Campo  , Russell Leek  , Zainina Seman  , Helen Turley  , Domenico Delia  , Alfredo Cesario  , Kevin Gatter  , Francesco Pezzella  
Published: July 2013

Tumor necrosis factor receptor associated protein 1(TRAP1) is a member of the Hsp90 family that acts as a molecular chaperon to the tumor suppressor retinoblastoma susceptibility gene (RB1). We have previously demonstrated that TRAP1-positive cells contain a high level of cell proliferating genes, whilst TRAP1-negative cells contain a high level of genes involved in cell cycles and metastases. In this study, we performed a functional analysis of TRAP1 which focused on its regulation within a cell cycle in relation to RB1. Following a heat shock, TRAP1 translocates to the nucleus and chaperonsRB1. When TRAP1 is silenced by siRNA, or prevented from entering the nucleus in hypoxic cells, formation of RB1/E2F1 complexes is impaired and cell cycle activity is promoted by deregulating the G1/S transition. Inhibition of the nuclear translocation of TRAP1 with geldanamycin abrogates its ability to maintain RB1 in a form that associates with E2F1. Restoration of TRAP1 expression reverses these effects. We analysed TRAP1/RB1 expression on 630 tumors by immunohistochemical staining and found TRAP1 lost in some types of cancer, such as non-small cell lung cancer and breast cancer, and the positive correlation of TRAP1 expression in nuclear and cytoplasm with RB1 was observed. Clinico-pathological data showed that breast carcinoma patients lacking nuclear TRAP1 have a shorter disease free survival. Our data suggests that nuclear translocation of TRAP1 is crucial for its function as a chaperon. The loss of TRAP1 expression in certain types of cancer may provide the growth advantage due to the lost control at cell cycle check point.
Molecular Genetic Study of the Allelic State of the Cell Cycle Genes (TP53, BRCA1) and Features of the Regulation of the Cytokine Cascade in Breast Cancer
Authors: S.K. Gantsev  , V.Y. Gorbunova  , G.F. Galikeeva  , E.V. Vorobyeva  , E.M. Vasilyeva  , R.A. Rustamhanov  
Published: July 2013

This article contains the analysisof mutationsin genesthat regulate thecell cycle (TP53andBRCA1)andclassificationrelating totumor suppressor. Shown that the"risk"alleles of thesegenesmay contribute totumor development,butthe activation ofthe immune systemcytokine spectrumof patients canprevent theirdestructivedegeneration.The authors proposed apersonalizedapproach tothe study for thepreventionof possibleproliferative processes. This is confirmed byreversal of "risk" allelesstudied genesin tumors in operated patients with cytokine physiologically normal status.
Training Mothers in Infant Cardiopulmonary Resuscitation With an Instructional DVD and Manikin
Authors: Barr Gavin C. , Rupp Valerie A. , Hamilton Kimberly M. , Worrilow Charles C. , Reed James F. , Friel Kristin S. , Dusza Stephen W. , Greenberg Marna Rayl 
Published: July 2013

Abstract

Context: Classes in infant cardiopulmonary resuscitation (CPR) can be time consuming and costly.

Objective: To determine whether mothers in an obstetric unit could learn infant CPR by using a 22-minute instructional kit and to assess the value and confidence they gained by learning CPR.

Design: Quasi-experimental study with enrollment between January and December 2008.

Setting: Obstetric unit in Lehigh Valley Hospital, a suburban teaching hospital in Allentown, Pennsylvania.

Participants: Mothers at least 18 years old who had given birth within the previous 24 hours.

Intervention: The experimental group included mothers without prior CPR training who watched a 22-minute instructional DVD and practiced on a manikin. The control group included mothers with prior conventional CPR training.

Main Outcome Measures: In both groups, knowledge and proficiency were assessed with written and practical examinations developed by certified CPR instructors. Participant surveys were conducted at 3 times: immediately before dissemination of course materials, within 24 hours after the mother agreed to participate in the study, and 6 months after initial evaluation.

Results: A total of 126 mothers were enrolled in the study: 79 in the experimental group, 25 in the control group, and 22 who withdrew from the study. Written and practical examinations were used to determine proficiency, and composite scores were generated, with a maximum composite score of 12. The composite scores were statistically significantly higher in the experimental group than in the control group, with median scores of 10 and 7, respectively (P<.001). Twenty-two mothers (21%) had been previously offered CPR training. In the experimental group, 76 mothers (96%) felt more confident as caregivers after learning CPR. Before training in both groups, 84 mothers (81%) stated that learning CPR was extremely important, compared with 100 mothers (96%) after training (P=.001).

Conclusion: Use of an instructional kit is an effective method of teaching CPR to new mothers. Mothers reported that learning CPR is extremely important and that it increases their confidence as caregivers.
Massive Anisotropic Thermal Expansion and Thermo‐Responsive Breathing in Metal–Organic Frameworks Modulated by Linker Functionalization
Authors: Henke Sebastian , Schneemann Andreas , Fischer Roland A. 
Published: July 2013

AbstractFunctionalized metal–organic frameworks (fu‐MOFs) of general formula [Zn2(fu‐L)2dabco]n show unprecedentedly large uniaxial positive and negative thermal expansion (fu‐L = alkoxy functionalized 1,4‐benzenedicarboxylate, dabco = 1,4‐diazabicyclo[2.2.2]octane). The magnitude of the volumetric thermal expansion is more comparable to property of liquid water rather than any crystalline solid‐state material. The alkoxy side chains of fu‐L are connected to the framework skeleton but nevertheless exhibit large conformational flexibility. Thermally induced motion of these side chains induces extremely large anisotropic framework expansion and eventually triggers reversible solid state phase transitions to drastically expanded structures. The thermo‐responsive properties of these hybrid solid–liquid materials are precisely controlled by the choice and combination of fu‐Ls and depend on functional moieties and chain lengths. In principle, this combinatorial approach allows for a targeted design of extreme thermo‐mechanical properties of MOFs addressing the regime between crystalline solid matter and the liquid state.
Plasmonics in Nanostructures
Authors: Fang Zheyu , Zhu Xing 
Published: June 2013

AbstractPlasmonics has developed into one of the rapidly growing research topics for nanophotonics. With advanced nanofabrication techniques, a broad variety of nanostructures can be designed and fabricated for plasmonic devices at nanoscale. Fundamental properties for both surface plasmon polaritons (SPP) and localized surface plasmons (LSP) arise a new insight and understanding for the electro‐optical device investigations, such as plasmonic nanofocusing, low‐loss plasmon waveguide and active plasmonic detectors for energy harvesting. Here, we review some typical functional plasmonic nanostructures and nanosmart devices emerging from our individual and collaborative research works.
Sandwich‐Type Microporous Carbon Nanosheets for Enhanced Supercapacitor Performance
Authors: Hao Guang‐Ping , Lu An‐Hui , Dong Wei , Jin Zhen‐Yu , Zhang Xiang‐Qian , Zhang Jin‐Tao , Li Wen‐Cui 
Published: June 2013

AbstractSandwich‐type microporous hybrid carbon nanosheets (MHCN) consisting of graphene and microporous carbon layers are fabricated using graphene oxides as shape‐directing agent and the in‐situ formed poly(benzoxazine‐co‐resol) as carbon precursor. The reaction and condensation can be readily completed within 45 min. The obtained MHCN has a high density of accessible micropores that reside in the porous carbon with controlled thickness (e.g., 17 nm), a high surface area of 1293 m2 g−1 and a narrow pore size distribution of ca. 0.8 nm. These features allow an easy access, a rapid diffusion and a high loading of charged ions, which outperform the diffusion rate in bulk carbon and are highly efficient for an increased double‐layer capacitance. Meanwhile, the uniform graphene percolating in the interconnected MHCN forms the bulk conductive networks and their electrical conductivity can be up to 120 S m−1 at the graphene percolation threshold of 2.0 wt.%. The best‐practice two‐electrode test demonstrates that the MHCN show a gravimetric capacitance of high up to 103 F g−1 and a good energy density of ca. 22.4 Wh kg−1 at a high current density of 5 A g−1. These advanced properties ensure the MHCN a great promise as an electrode material for supercapacitors.
Craniosynostosis and radial ray defect: A rare presentation of 22q11.2 deletion syndrome
Authors: Rojnueangnit Kitiwan , Robin Nathaniel H. 
Published: June 2013

AbstractA newborn with bilateral coronal craniosynostosis, hypoplastic thumbs, imperforate anus, and prenatal growth restriction was evaluated and given the clinical diagnosis of Baller–Gerold syndrome (BGS). While confirmatory testing of RECQL4 was pending, the infant developed unexplained hypocalcemia, prompting testing for a 22q11.2 deletion. Subsequently, the infant was found to have a 22q11.2 deletion, and was negative for an RECQL4 mutation. We therefore conclude that 22q11.2 deletion syndrome can present with findings resembling the BGS phenotype. © 2013 Wiley Periodicals, Inc.
Seven‐tesla phase imaging of acute multiple sclerosis lesions: A new window into the inflammatory process
Authors: Absinta Martina , Sati Pascal , Gaitán María I. , Maggi Pietro , Cortese Irene C. M. , Filippi Massimo , Reich Daniel S. 
Published: June 2013

ObjectiveIn multiple sclerosis (MS), accurate, in vivo characterization of dynamic inflammatory pathological changes occurring in newly forming lesions could have major implications for understanding disease pathogenesis and mechanisms of tissue destruction. Here, we investigated the potential of ultrahigh‐field magnetic resonance imaging (MRI; 7T), particularly phase imaging combined with dynamic contrast enhancement, to provide new insights in acute MS lesions.MethodsSixteen active MS patients were studied at 7T. Noncontrast, high‐resolution T2* magnitude and phase scans, T1 scans before/after gadolinium contrast injection, and dynamic contrast‐enhanced (DCE) T1 scans were acquired. T2*/phase features and DCE pattern were determined for acute and chronic lesions. When possible, 1‐year follow‐up 7T MRI was performed.ResultsOf 49 contrast‐enhancing lesions, 44 could be analyzed. Centrifugal DCE lesions appeared isointense or hypointense on phase images, whereas centripetal DCE lesions showed thin, hypointense phase rims that clearly colocalized with the initial site of contrast enhancement. This pattern generally disappeared once enhancement resolved. Conversely, in 43 chronic lesions also selected for the presence of hypointense phase rims, the findings were stable over time, and the rims were typically thicker and darker. These considerations suggest different underlying pathological processes in the 2 lesion types.InterpretationUltrahigh‐field MRI and, especially, phase contrast, are highly sensitive to tissue changes in acute MS lesions, which differ from the patterns seen in chronic lesions. In acute lesions, the hypointense phase rim reflects the expanding inflammatory edge and may directly correspond to inflammatory byproducts and sequelae of blood–brain barrier opening. Ann Neurol 2013;74:669–678
Fe‐Beta catalysts prepared by heating wet ion exchange and their catalytic performances on N2O catalytic decomposition and reduction
Authors: Lu Renjie , Zhang Xinyan , Ma Chunyan , Wang Zhuo , Wang Yufei , Hao Zhengping 
Published: July 2013

ABSTRACTA heating wet ion exchange method was successfully used to synthesize Fe‐beta catalysts by controlling preparation conditions. The iron loading of Fe‐beta catalysts increased from 0.88% to 16.56% with raising the ion exchange temperature from 20 to 90 °C. Their catalytic activities for N2O decomposition and N2O reduction by NH3 were evaluated. The activity results show that the catalyst prepared at 80 °C (Fe‐beta‐80 °C) could achieve complete N2O decomposition at 480 °C and N2O reduction by NH3 at 375 °C. The iron species of catalysts were further characterized by X‐ray diffraction, transmission electron microscopy (TEM), UV–vis, H2 temperature programmed reduction, and NH3 temperature programmed desorption techniques. The characterization results indicate that related high content of isolated Fe3+ ions and oligonuclear Fe3+xOy clusters existed in the Fe‐beta‐80 °C catalyst, which contributed to the high catalytic activity. Moreover, after the reaction of more than 100 h, Fe‐beta‐80 °C catalyst has no obvious deactivation under simulated emission conditions. The presence of O2 (5%) reduced N2O conversion only to a small extent, whereas NO (1000 ppm) promoted the N2O decomposition over Fe‐beta‐80 °C. © 2013 Curtin University of Technology and John Wiley & Sons, Ltd.
Polyaniline nanocomposites with negative permittivity
Authors: Gu Hongbo , Guo Jiang , Wei Suying , Guo Zhanhu 
Published: June 2013

ABSTRACTIn this review, the fundamentals of negative permittivity are critically discussed. Current research on polyaniline and its nanocomposites with negative permittivity are presented in detail. The reasons why these unique materials show negative permittivity are analyzed. This knowledge will be useful for future metacomposite design and manufacturing. These polymeric materials with negative permittivity are envisioned to create next‐generation left‐hand media for cloaking, subwavelength imaging, stealth, and invisibility applications. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 2238–2244, 2013