bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Wound Healing Complications After Wide Excision of Injection Site Sarcomas of the Trunk of Cats
Authors: Cantatore Matteo , Ferrari Roberta , Boracchi Patrizia , Gobbetti Matteo , Travetti Olga , Ravasio Giuliano , Giudice Chiara , Di Giancamillo Mauro , Grieco Valeria , Stefanello Damiano 
Published: May 2014

ObjectiveWide surgery is the mainstay of the multimodal treatment of injection site sarcomas (ISS) in cats. The aim of the study was to analyze potential factors influencing the development of wound healing complications (WHC) in cats undergoing wide excision of ISS.Study designRetrospective case series.AnimalsForty‐nine cats with ISS located on the trunk underwent wide excision after contrast‐enhanced computed tomography planning.MethodsThe prognostic effect of covariates (sex, age, weight, body condition score (BCS), site, clinical dimension (CD), computed tomographic dimension (CTD), histotype, duration of surgery, surgical margin status, local anesthesia) on total, major and minor WHC was evaluated by univariate and bivariate analysis. Cox model was used for total WHC and Fine and Gray model was used for major and minor WHC. The relationship between duration of surgery and clinical and imaging variables was evaluated.ResultsThe main factor associated to the risk of total and major WHC was surgical time. Based on univariate analysis, pattern of reconstruction, CDT, CD, weight, and BCS were significant prognostic factors for major WHC, but this was not confirmed when adjusted for other clinical variables in bivariate analysis. The duration of surgery was influenced by excision pattern and tumor CTD width.ConclusionsAn increased duration of surgery as the consequence of complex surgical procedures represented the best predictor for the development of WHC.
Evaluation of Rare‐Earth Modified ZrB2–SiC Ablation Resistance Using an Oxyacetylene Torch
Authors: Tan Winnie , Adducci Mitchell , Trice Rodney 
Published: May 2014

Rare‐earth modified ZrB2–SiC coatings were prepared via mechanical mixing Sm2O3 or Tm2O3 powders with spray‐dried ZrB2, or by chemically doping samarium ions into spray‐dried ZrB2. In either approach, SiC powders were also added and coatings were fabricated via shrouded air plasma spray. An oxyacetylene torch was utilized to evaluate the coatings under high heat flux conditions for hold times of 30 and 60 s. The resulting phases and microstructures were evaluated as a function of rare‐earth type, modification approach, and ablation time. A brittle m‐ZrO2 scale was observed in the ZrB2/SiC‐only coating after ablative tests; during cooling this scale detached from the unreacted coating. In contrast, rare‐earth modified coatings formed a protective oxide scale consisting primarily of either Sm0.2Zr0.8O1.9 or Tm0.2Zr0.8O1.9, along with small amount of m‐ZrO2. These rare‐earth oxide scales displayed high thermal stability and remained adhered to the unreacted coating during heating and cooling, offering additional oxidation protection.
Y3Al5O12–SiO2 Glasses: Structure and Polyamorphism
Authors: Nasikas Nektarios K. , Retsinas Andreas , Papatheodorou George N. 
Published: May 2014

Aerodynamic levitation and CO2 laser melting have been used to synthesize the yttrium aluminosilicate glasses zY2O3–yAl2O3–xSiO2 with z/y = 3/5 corresponding to the YAG (Y3Al5O12) composition and x between ~5 and ~45 mol%. The low‐ and high‐density (LDA inclusion and HDA matrix) polyamorphic phases in glasses with less than ~14 mol% SiO2 were identified with backscattering electron imaging. Polarized and depolarized Raman spectra show the formation of various Qn SiO4 species whose relative populations change smoothly as the SiO2 content is altered. The AlOs (s = 4–6) and YOz (z = 6–9) polyhedra formed in the YAG glass are preserved upon silica additions while the terminal oxygens of the Q2AlO4 tetrahedra are gradually bridged to the Qn‐SiO4 species. The low‐frequency Boson Peak overlaps with the vibrational spectrum and its maximum is redshifted with increasing silica content. Micro‐Raman spectra measured for the LDA and HDA amorphous phases are found to be similar to the spectra of the bulk glass indicating common structural characteristics. The stability of the LDA phase against crystallization appears to be lower than that of the HDA phase. The crystallinity on certain inclusions consisted of YAG microcrystals and a new unidentified microcrystalline phase within Y4Al2(1−x)Si2xO(9+x) solid solution.
Aluminum Incorporation in the C–S–H Phase of White Portland Cement–Metakaolin Blends Studied by 27Al and 29Si MAS NMR Spectroscopy
Authors: Dai Zhuo , Tran Thuan T. , Skibsted Jørgen 
Published: May 2014

The composition and structure of the calcium‐silicate‐hydrate (C–S–H) phases formed by hydration of white portland cement–metakaolin (MK) blends have been investigated using 27Al and 29Si MAS NMR. This includes blends with 0, 5, 10, 15, 20, 25, 30 wt% MK, following their hydration from 1 d to 1 yr. 29Si MAS NMR reveals that the average Al/Si ratio for the C–S–H phases, formed by hydration of the portland cement–MK blends, increases almost linearly with the MK content but is invariant with the hydration time for a given MK content. Correspondingly, the average aluminosilicate chain lengths of the C–S–H increase with increasing MK content, reflecting the formation of a C–S–H with a lower Ca/Si ratio. The increase in Al/Si ratio with increasing MK content is supported by 27Al MAS NMR which also allows detection of strätlingite and fivefold coordinated aluminum, assigned to AlO5 sites in the interlayer of the C–S–H structure. Strätlingite is observed after prolonged hydration for MK substitution levels above 10 wt% MK. This is at a somewhat lower replacement level than expected from thermodynamic considerations which predict the formation of strätlingite for MK contents above 15 wt% after prolonged hydration for the actual portland cement–MK blends. The increase in fivefold coordinated Al with increasing MK content suggests that these sites may contribute to the charge balance of the charge deficit associated with the incorporation of Al3+ ions in the silicate chains of the C–S–H structure.
Combining genetic analyses of archived specimens with distribution modelling to explain the anomalous distribution of the rare lichen Staurolemma omphalarioides: long‐distance dispersal or vicariance?
Authors: Bendiksby Mika , Mazzoni Sabrina , Jørgensen Marte H. , Halvorsen Rune , Holien Håkon 
Published: May 2014

AbstractAimThe rare lichen species Staurolemma omphalarioides is known mainly from the lowlands and coastal areas of the Mediterranean region but has also been found in coastal parts of central Norway. Despite extensive search efforts by experts for more than half a century, the species has been found nowhere in the gap. Our aim is to identify the most plausible explanation for this anomalous distribution by combining genetic analysis of archived specimens with distribution modelling.LocationEurope, western Middle East and North Africa (but mainly the Mediterranean and Atlantic floristic regions).MethodsWe used multi‐locus DNA sequencing of archived specimens and phylogenetic and network analyses to reveal potential genetic lineages within S. omphalarioides. We used georeferenced specimens and bioclimatic variables to model the distributions of the species and two genetic lineages, and to find the main environmental correlates of the distributions.ResultsOur phylogeographical results show that S. omphalarioides contains genetic variation that correlates with geographical distance, although with a few shared haplotypes across disjunct ranges. Distributions of the species as well as the two genetic lineages are non‐random. Distribution models predict occurrences of the species as well as one of its genetic lineages outside the current range of the species.Main conclusionsOur results indicate that neither the species nor its component genetic lineages have reached their potential distributions. Shared haplotypes across disjunct distributions, and absence from regions with suitable refugial habitats along the Atlantic coast of Western Europe, support long‐distance dispersal, rather than vicariance, as the primary cause for the current distribution of the species.
Outcomes of Lead Revision for Myocardial Perforation After Cardiac Implantable Electronic Device Placement
Authors: HUANG XIN‐MIAO , FU HAI‐XIA , ZHONG LI , OSBORN MICHAEL J. , ASIRVATHAM SAMUEL J. , SINAK LAWRENCE J. , CAO JIANG , FRIEDMAN PAUL A. , CHA YONG‐MEI 
Published: May 2014

Percutaneous Lead Revision for Cardiac PerforationIntroductionCardiac perforation is an infrequent but potentially life‐threatening complication associated with placement of a cardiac implantable electronic device (CIED). The objective of this study was to determine the outcomes of percutaneous lead revision in patients who had lead perforation of the myocardium after CIED placement.Methods and ResultsWe reviewed records of 1,458 patients who underwent CIED lead extraction or repositioning. Of these, 31 (2.1%) had the procedure performed for lead perforation as a complication of CIED placement. Demographic, clinical, and follow‐up characteristics of the patients were analyzed. Mean (SD) patient age was 65 (23) years. Cardiac perforation was detected within 24 hours after implantation in 9 patients, within 1 month in 17, and greater than 1 month in 5. Pericardiocentesis was performed with a pigtail drainage catheter in place before the lead revision in 17 patients (55%) who had pericardial effusion, with or without hemodynamic compromise. All culprit leads were successfully managed with percutaneous lead removal (n = 3 [10%]), new lead placement (n = 12 [38%]), or lead repositioning (n = 16 [52%]). Of the 17 patients with pericardiocentesis before the reoperation, none had tamponade develop; in contrast, 3 of the remaining 14 patients had tamponade develop and required urgent pericardiocentesis. All patients survived without requiring open chest surgery.ConclusionPercutaneous removal or repositioning of the perforating lead is feasible and appears effective. Placement of a prophylactic pericardial drain catheter may reduce the incidence of urgent pericardiocentesis during or after a procedure.
Risk of thromboembolism and fatal stroke in patients with psoriasis and nonvalvular atrial fibrillation: a Danish nationwide cohort study
Authors: Ahlehoff O. , Gislason G. , Lamberts M. , Folke F. , Lindhardsen J. , Larsen C. T. , Torp‐Pedersen C. , Hansen P. R. 
Published: May 2014

AbstractObjectivesPsoriasis is a chronic inflammatory disease that is associated with a prothrombotic state and cardiovascular disease, including atrial fibrillation and thromboembolism. We therefore evaluated the impact of psoriasis in patients with atrial fibrillation and the performance of the CHA2DS2VASc score in these patients.Design, setting and participantsThe study comprised all Danish patients hospitalized with nonvalvular atrial fibrillation in the period 1997–2011 (n = 99 357). Follow‐up started 7 days from discharge and excluded subjects treated with anticoagulation. Poisson regression adjusted for CHA2DS2VASc score was used to estimate the incidence rate ratios and 95% confidence intervals.Main outcome measureHospitalization or death from thromboembolism.ResultsMean follow‐up was 3.5, 3.1, and 2.8 years for patients with no psoriasis, mild psoriasis and severe psoriasis, respectively. Patients with psoriasis were younger compared to patients without psoriasis, but CHA2DS2VASc score did not differ between the three groups. Thromboembolism rates per 100 patient‐years (95% confidence intervals) were 4.8 (4.7–4.9), 4.8 (4.2–5.4) and 6.1 (5.0–7.5) for patients with no psoriasis, mild psoriasis and severe psoriasis, respectively. Importantly, the observed thromboembolism rates in patients with severe psoriasis were markedly higher (2.6‐ to3.4‐fold) than predicted by the CHA2DS2VASc score. Relative to no psoriasis, incidence rate ratios were 0.99 (0.87–1.11) and 1.27 (1.02–1.57) for mild and severe psoriasis, respectively. Correspondingly, incidence rate ratios for fatal stroke were 0.97 (0.80–1.12) and 1.51 (1.12–2.05).ConclusionsIn patients with nonvalvular atrial fibrillation not treated with oral anticoagulation, severe psoriasis was associated with increased risk of thromboembolism. In these patients, CHA2DS2VASc underestimated the risk of thromboembolism.
The Roles of Values, Behavior, and Value‐Behavior Fit in the Relation of Agency and Communion to Well‐Being
Authors: Buchanan Kathryn , Bardi Anat 
Published: May 2014

AbstractFour studies examined whether agency and communion values, behaviors, or an interaction between values and behaviors (value‐behavior fit) would predict well‐being. In addition, Study 2 examined whether agency and communion goals, behaviors, or goal‐behavior fit would predict well‐being. In all four studies, participants completed online questionnaires containing measures of agency and communion values, behaviors, and well‐being. In Studies 1 and 4, participants were recruited from the general population (respectively, N = 371, Mage = 37.49, and N = 133, Mage = 36.59). In Studies 2 and 3, participants were undergraduate students (respectively, N = 239, Mage = 20.8, and N = 242, Mage = 21.6). All four studies consistently found that agency and communion behaviors were significantly positively correlated with both subjective and psychological well‐being. There was no strong indication that either values were directly associated with well‐being. Neither was there any indication that well‐being was predicted by value‐behavior fit. The implications of these findings for theory and improving well‐being are discussed.
Prescription of opioid and nonopioid analgesics for dental care in emergency departments: Findings from the National Hospital Ambulatory Medical Care Survey
Authors: Okunseri Christopher , Okunseri Elaye , Xiang Qun , Thorpe Joshua M. , Szabo Aniko 
Published: May 2014

AbstractObjectivesThe aim of this study was to examine trends and associated factors in the prescription of opioid analgesics, nonopioid analgesics, opioid and nonopioid analgesic combinations, and no analgesics by emergency physicians for nontraumatic dental condition (NTDC)‐related visits. Our secondary aim was to investigate whether race/ethnicity is a possible predictor of receiving a prescription for either type of medication for NTDC visits in emergency departments (EDs) after adjustment for potential covariates.MethodsWe analyzed data from the National Hospital Ambulatory Medical Care Survey for 1997‐2000 and 2003‐2007, and used multinomial multivariate logistic regression to estimate the probability of receiving a prescription for opioid analgesics, nonopioid analgesics, or a combination of both, compared with receiving no analgesics for NTDC‐related visits.ResultsDuring 1997‐2000 and 2003‐2007, prescription of opioid analgesics and combinations of opioid and nonopioid analgesics increased, and that of no analgesics decreased over time. The prescription rates for opioid analgesics, nonopioid analgesics, opioid and nonopioid analgesic combinations, and no analgesics for NTDC‐related visits in EDs were 43 percent, 20 percent, 12 percent, and 25 percent, respectively. Majority of patients categorized as having severe pain received prescriptions for opioids for NTDC‐related visits in EDs. After adjusting for covariates, patients with self‐reported dental reasons for visit and severe pain had a significantly higher probability of receiving prescriptions for opioid analgesics and opioid and nonopioid analgesic combinations.ConclusionsPrescription of opioid analgesics increased over time. ED physicians were more likely to prescribe opioid analgesics and opioid and nonopioid analgesic combinations for NTDC‐related visits with reported severe pain.
Comparison of Adrenocorticotropic Hormone Stimulation Test Results Started 2 versus 4 Hours after Trilostane Administration in Dogs with Naturally Occurring Hyperadrenocorticism
Authors: Bonadio C.M. , Feldman E.C. , Cohen T.A. , Kass P.H. 
Published: May 2014

BackgroundTrilostane medical treatment of naturally occurring hyperadrenocorticism (NOH) in dogs is common, as is use of the adrenocorticotropic hormone (ACTH) stimulation test (ACTHst) in monitoring response to treatment. There is uncertainty regarding when theACTHst should be started relative to time of trilostane administration.ObjectiveTo compareACTHst results in dogs being treated forNOHwith trilostane when the test is begun 2 versus 4 hours after trilostane administration.AnimalsTwenty‐one privately owned dogs withNOH, each treated with trilostane for at least 30 days.MethodsEach dog had 2ACTHst completed, 1 started 2 hours and the other 4 hours after trilostane administration. The second test was started no sooner than 46 hours and no later than 74 hours after the first.ResultsFor all 21 dogs, the mean post‐ACTHserum cortisol concentration from tests started 2 hours after trilostane administration (5.4 ± 3.7 μg/dL) was significantly lower (P = .03) as compared with results from the tests started 4 hours after administration (6.5 ± 4.5 μg/dL).ConclusionsResults ofACTHst started at different times yield significantly different results. Dogs withNOH, treated with trilostane, and monitored withACTHst results should have all of their subsequentACTHst tests begun at or about the same time after trilostane administration.
Our 2014 approach to candidaemia
Authors: Koehler Philipp , Tacke Daniela , Cornely Oliver A. 
Published: May 2014

SummaryCandidaemia remains a relevant challenge in everyday patient care on intensive care units and general wards. Delays to adequate treatment increase mortality rates and institutional standard operating procedures facilitate optimal treatment. A positive blood culture requires immediate treatment. Echinocandins are the first‐line drugs of choice. Indwelling catheters have to be removed if feasible. Daily blood cultures until persistently negative exclude ongoing fungaemia. In case of Candida parapsilosis antifungal therapy should be switched to intravenous fluconazole. After 10 days of intravenous either echinocandin or fluconazole treatment, step‐down to oral application of fluconazole simplifies antifungal therapy. Depending on organ involvement and clinical presentation of the patient antifungal treatment should be continued for at least 14 days after the last positive blood culture. We present our institutional management algorithm for candidaemia which is based on current guidelines and recommendations to improve patient outcome.
Hippocampus and cerebral cortex present a different autophagic response after oxygen and glucose deprivation in an ex vivo rat brain slice model
Authors: Pérez‐Rodríguez Diego , Anuncibay‐Soto Berta , Llorente Irene L. , Pérez‐García Carlos C. , Fernández‐López Arsenio 
Published: May 2014

AimsTo evaluate the neuroprotective role of autophagy in the cerebral cortex and hippocampus using an ex vivo animal model of stroke in brain slices.MethodsBrain slices were maintained for 30 min in oxygen and glucose deprivation (OGD) followed by 3 h in normoxic conditions to simulate the reperfusion that follows ischaemia in vivo (RL, reperfusion‐like). Phagophore formation (Beclin 1 and LC3B) as well as autophagy flux (p62/SQSTM1, Atg5, Atg7 and polyubiquitin) markers were quantified by Western blot and/or qPCR. The release of lactate dehydrogenase (LDH) and glutamate in the medium was used as a measure of the mortality in the absence and in the presence of the autophagy inhibitor 3‐methyladenine.ResultsStriking differences in the autophagy markers were observed between the hippocampus and cerebral cortex in normoxic conditions. OGD/RL induced increases both in the phagophore formation and in the autophagy flux in the first three hours in the cerebral cortex that were not observed in the hippocampus. The blocking of autophagy increased the OGD/RL‐induced mortality, increased the glutamate release in both the cerebral cortex and hippocampus and abolished the OGD‐induced decrease in the polyubiquitinated proteins in the cerebral cortex.ConclusionsWe conclude that OGD induces a rapid autophagic response in the cerebral cortex that plays a neuroprotective role. Polyubiquitination levels and control of the glutamate release appear to be involved in the neuroprotective role of autophagy.
Esophageal distension during bolus transport: can it be detected by intraluminal impedance recordings?
Authors: Kim J. H. , Mittal R. K. , Patel N. , Ledgerwood M. , Bhargava V. 
Published: May 2014

AbstractBackgroundEsophageal multiple intraluminal impedance (MII) measurement has been used to detect gastro‐esophageal reflux and bolus transport. It is not clear if MII can detect changes in luminal cross sectional area (CSA) during bolus transport. Intraluminal ultrasound (US) images, MII, and high resolution manometry (HRM) were recorded simultaneously to determine temporal relationship between CSA and impedance during esophageal bolus transport and to define the relationship between peak distension and nadir impedance.MethodsStudies were conducted in five healthy subjects. MII, HRM, and US images were recorded 6 cm above LES. Esophageal distensions were studied during swallows and injections of 0.5 N saline bolus into the esophagus.Key ResultsTemporal change in esophageal CSA correlates with changes in impedance (r‐value: mean ± SD = −0.80 ± 0.08, range: −0.94 to −0.66). Drop in impedance during distension occurs as a two‐step process; initial large drop associated with onset of CSA increase, followed by a small drop during which majority of the CSA increase occurs. Peak CSA and nadir impedance occur within 1 s of each other. Increase in swallow and injection volumes increased the CSA, had no effect on large drop but increased the small drop amplitude. We observed a significant correlation between peak CSA and nadir impedance (r = −0.90, p < 0.001) and a better correlation between peak CSA and inverse impedance (r = 0.94, p < 0.001).Conclusions & InferencesFurther studies are needed to confirm that intraluminal impedance recordings may be used to measure luminal CSA during esophageal bolus transport.
Distinct subcellular localization of the neuronal marker HuC/D reveals hypoxia‐induced damage in enteric neurons
Authors: Desmet A.‐S. , Cirillo C. , Vanden Berghe P. 
Published: May 2014

AbstractBackgroundCorrect neuronal identification is essential to study neurons in health and disease. Although commonly used as pan‐neuronal marker, HuC/D's expression pattern varies substantially between healthy and (patho)physiological conditions. This heterogenic labeling has received very little attention. We sought to investigate the subcellular HuC/D localization in enteric neurons in different conditions.MethodsThe localization of neuronal RNA‐binding proteins HuC/D was investigated by immunohistochemistry in the mouse myenteric plexus using different toxins and caustic agents. Preparations were also stained with Sox10 and glial fibrillary acidic protein (GFAP) antibodies to assess enteric glial cell appearance.Key ResultsMechanically induced tissue damage, interference with the respiratory chain and oxygen (O2) deprivation increased nuclear HuC/D immunoreactivity. This effect was paralleled by a distortion of the GFAP‐labeled glial network along with a loss of Sox10 expression and coincided with the activation of a non‐apoptotic genetic program. Chemically induced damage and specific noxious stimuli did not induce a change in HuC/D immunoreactivity, supporting the specific nature of the nuclear HuC/D localization.Conclusions & InferencesHuC/D is not merely a pan‐neuronal marker but its subcellular localization also reflects the condition of a neuron at the time of fixation. The functional meaning of this change in HuC/D localization is not entirely clear, but disturbance in O2 supply in combination with the support of enteric glial cells seems to play a crucial role. The molecular consequence of changes in HuC/D expression needs to be further investigated.