bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Hybrid Multi-Criteria Decision Making Approach for Material Selection in Biomedical Ultrasound Imaging Experiments.
Authors: Sahu Amita , Sinha Niraj 
Published: August 2024

Abstract

In this paper, we present a multi-criteria prioritization of tissue-mimicking materials for ultrasound elastography imaging experiments. A decision matrix with target-based criteria and interval data has been formed to rank the nine most suitable materials for the application based on nine target-based decision criteria. Criteria weights are calculated using the best-worst method (BWM), the entropy weight method, and the correlation of criteria weights. The existing Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method is not suitable for the multi-criteria decision making (MCDM) problems in biomedical applications where target-based criteria and uncertain data are involved. Therefore, to use the TOPSIS method for such problems, the method has been modified and named the Interval data and Target criteria based TOPSIS (IT-TOPSIS) method. This IT-TOPSIS method and an extended VlseKriterijuska Optimizacija I Komoromisno Resenje (VIKOR) method are then used to rank the materials. The study found that polyvinyl alcohol (PVA) is the best-suited soft tissue-mimicking material for ultrasound elastography imaging experiments, followed by gelatine and polyethylene glycol diacrylate (PEGDA).
Ailanthone Increases Cisplatin-induced Apoptosis and Autophagy in Cisplatin Resistance Non-small Cell Lung Cancer Cells through the
PI3K/AKT/mTOR Pathway
Authors: Di Jinna , Bo Wei , Wang Chun , Liu Chunying 
Published: August 2024

Introduction:
The effectiveness of therapy is strongly impacted by the resistance
of lung cancer cells to cisplatin. The objective of this research is to characterize
the impact of ailanthone on cisplatin resistance in non-small cell lung cancer (NSCLC)
and examine any potential in vivo and in vitro molecular pathways.

Methods:
Following treatment of A549/DDP cells with ailanthone and cisplatin, cell survival
and apoptosis were measured using flow cytometry and Cell Counting Kit-8 (CCK-
8) assays, respectively. mRFP-GFP-LC3 adenovirus transfection was used to track autophagy,
and protein expression levels were analyzed by western blotting. Hematoxylin
and eosin (H&E) staining was used after the organs of the mice were removed for in
vivo investigations. In A549/DDP cells, ailanthone and cisplatin together induced autophagy
and apoptosis in a dose and time-dependent manner (P< 0.05). After receiving
combined treatment with ailanthone and cisplatin, the expression levels of cleaved caspase-
3, Bcl-2, cleaved PARP, Beclin1L, and C3B-II were considerably elevated by inhibiting
the PI3K/AKT/mTOR signaling pathway.

Result:
Our findings show that ailanthone, without causing adverse effects in vivo, greatly
suppressed the growth of A549/DDP-grafted tumors and improved the anti-tumor efficaciousness
of cisplatin.

Conclusion:
According to this study, ailanthone may increase sensitivity to cisplatin
and promote autophagy and death in NSCLC A549/DDP cells through the signaling
pathway of PI3K/AKT/mTOR.
GPX4 Inhibition Enhances the Antitumor Effect of PARP Inhibitor on Homologous Recombination Proficient Ovarian Cancer Cells
Authors: Gu Jiaxin , Qian Senmi , Qian Fangfang , Wu Xiaodong , Chen Lifeng , Chen Xiaojing , Chen Zhuoye , Song Feifei , Zheng Mengxia , Wang Lingfang , Cheng Xiaodong 
Published: August 2024

Background:
Poly (ADP-ribose) polymerase inhibitors (PARPi) are now widely used in BRCA1/2 mutation or homologous recombination (HR) deficiency ovarian cancer but have limited efficacy in HR-proficient patients. GPX4 is a key regulator of ferroptosis and has been proven to be associated with multiple drug sensitivities. As a molecule that regulates the sensitivity of multiple drugs, the relationship between GPX4 and the efficacy of PARPi in HR-proficient ovarian cancer has not been elucidated.

Methods:
In this study, siRNA transfection was used to regulate the expression of GPX4. The effect of GPX4 inhibition on HR-proficient ovarian cancer was determined by CCK-8 assay and flow cytometry. Immunofluorescence and comet assays were used to reflect DNA dam-age. ROS production was measured using DCFH-DA and flow cytometry. The combination index of PARP inhibitors and RSL3 was calculated using CompuSyn software based on Chou-Talalay methodology.

Results:
GPX4 inhibition confers HR-proficient ovarian cancer cells sensitive to PARPi due to ROS generation and oxidative stress caused by DNA double-strand breakage. The combina-tion of olaparib and niraparib with GPX4 inhibitor RSL3 also showed a synergistic effect.

Conclusion:
Combining GPX4 inhibition with PARP inhibitors resulted in a notable increase in DNA damage, ultimately causing the death of cancer cells with proficient HR pathways. Our findings may provide new therapeutic options for HR-proficient patients to benefit from PARP inhibitors and improve outcomes.
Mapping Systematic Reviews on the Management of Dental Caries in Primary Teeth: A Meta-Research
Authors: Pascareli-Carlos Aline Maquiné , Marchezini Reis Thaís , Fernandes de Novaes Tatiane , Fernandes Montagner Anelise , Helène van de Sande Françoise , Gimenez Thais , Prócida Raggio Daniela , Kerber Tedesco Tamara 
Published: August 2024

Background:
Systematic reviews (SRs) represent the most robust source of evidence for informing decision-making. While there are rigorous protocols for properly conducting SRs, sometimes the methodological biases in the primary studies are accounted for in the conclusions of the SRs.

Objective:
This study aimed to map the evidence regarding the management of caries lesions in primary teeth.

Methods:
Two reviewers conducted a systematic search up to March 2024 in electronic data-bases. Any SR concerning the management of caries lesions in primary teeth was considered eli-gible.

Results:
About 162 SRs were included. Among these, 80 focused on restorative treatments, 64 on endodontic treatments, and 18 on non-invasive treatments. Only 42.6% presented a study registra-tion protocol. The majority (67.9%) performed a meta-analysis, while a minority exclusively car-ried out qualitative data analysis. Despite 92.6% of the SRs evaluating the methodological quality or risk of bias of the primary studies using some tool, only 24% assessed the certainty of evidence using the GRADE approach, resulting in classifications ranging from very low to moderate.

Conclusion:
There is a limited adherence to study registration protocols, indicating a need for improvements in this practice. Additionally, among the few SRs that used the GRADE approach, the majority demonstrated levels of very low to moderate certainty.
Investigation of Lead, Cadmium, and Nickel in Water Samples from Al-Muthanna Governorate, Iraq, and Evaluation of The Pollution Indicators
Authors: Al-Hamzawi Anees A. , Kareem Qasim Sttar , Mohaimeed Ameen Alwan , HusseinAmwayshi Israa , Hussien Aseel Ali 
Published: August 2024

Background:
The Iraqi environment, especially in the southern region, has been contaminated
as a result of human activities. The detection of heavy metals in water samples is the preferred
method for monitoring the toxic levels, which are very important for environmental protection
and human health.

Methods:
Heavy metal concentrations of lead (Pb), cadmium (Cd), and nickel (Ni) were investigated
in water samples from Al-Muthanna governorate, southern Iraq. The selected water samples
were taken from different sources of tap water and river samples from the Euphrates and collected
from various locations: residential, agricultural, and industrial.

Results:
The mean values of Pb, Cd, and Ni in tap water samples are 3.76, 2.62, and 84.88 μg/L,
respectively, while the corresponding element levels in river water are 11.21, 7.58, and 104.31
μg/L, respectively. Rivers water samples recorded higher levels of toxic metals than tap water samples.
Concentrations of toxic elements in water samples from industrial locations of Al-Muthanna
governorate are higher than in the agricultural and residential places. Toxic metals in water samples
can be arranged in the following sequence: Ni > Pb > Cd.

Conclusion:
The levels of heavy metals in most water samples were above the permissible levels
according to USEPA; therefore, it is recommended that the water samples should be regularly
monitored for heavy metals to prevent the effect of heavy metals contamination in the human food
chain.
The Effect of Attending Major Wards on the Burnout and Boredom of Medical Interns during the COVID-19 Pandemic
Authors: Esmaeili Mahdieh , Ahmadi Atefeh , Alinaghi Langari Ahmad , Mayel Masoud 
Published: August 2024

Introduction:
The current study was conducted to investigate the effect of attending major
wards on the level of burnout and boredom of medical interns in Iran during the COVID-19 pandemic.

Methods:
The present study was a cross-sectional descriptive research on all medical interns at the
Kerman University of Medical Sciences of Iran who entered the major wards for the first time. Demographic
questionnaires, Maslach and Jackson job burnout, and Multidimensional Boredom Scale
(MSBS) were completed at the entrance and after two months. The mean scores (with the Wilcoxon
test) were compared with each other, and their relationship (with Pearson Chi-squared test and Kendall's
tau B) was investigated.

Results:
Investigations showed that emotional exhaustion significantly increased (p < 0.001), but
Depersonalization significantly reduced after 2 months. The mean scores of individual dysfunction
were not obvious (p>0.05). In addition, the fact that the intern is attending which ward (internal, surgery,
or obstetrics and gynecology) did not affect the amount of burnout (p>0.05). The mean of the
boredom scores increased significantly (p < 0.01).

Conclusion:
It is necessary to take serious measures to reduce emotional exhaustion in interns, especially
in epidemic or pandemic conditions.
PENGARUH JUMLAH UANG BEREDAR, SUKU BUNGA DAN NILAI TUKAR TERHADAP TINGKAT INFLASI DI INDONESIA MENGGUNAKAN PENDEKATAN ANALISIS JALUR PERIODE 2010Q1 – 2020Q4
Authors: Herania Elisabeth , Maski Ghozali 
Published: August 2024

Monetary policy is one of the important components in an economic system whose conditions are always uncertain. One of the most important objectives of monetary policy is to maintain price stability for goods and services. Price volatility, which is manifested as inflation, can have a bad long-term impact on the national economy if it is not controlled properly. Therefore, it is important to control inflation to maintain a healthy economic climate. A low and stable inflation rate is important for long-term economic growth. Monetary policy instruments that can maintain price stability include the money supply, interest rates and exchange rates. Therefore, this study aims to analyze the effect of JUB, interest rates and exchange rates on the inflation rate through path analysis method. Path analysis method is used to see the direct and indirect effect of the money supply on inflation through interest rates and exchange rates as intervening variables. The results showed that the money supply and exchange rate directly did not have a significant effect on the inflation rate. Meanwhile, interest rates have a significant direct effect on inflation. Indirectly, only interest rates have a role in mediating the relationship between the money supply and the inflation rate.

Keywords: monetary policy; inflation; money supply; interest rate; exchange rate; path analysis
The Influence of Promotion, Price, And Product Quality on Purchase Decision of Mild Cigarette Product
Authors: Dawanto Muhammad Alief Fitrah 
Published: August 2024

This study aims to determine the effect of promotion, price, and product quality on purchase decision of mild cigaratte product (consumer study on Sampoerna A Mild in Malang City). This type of research was an explanatory research with quantitative methods. This study used a sample of 100 respondents and sampling used non-probability sampling techniques by using the purposive sampling method. The criteria required for respondents in this study are at least 18 years old, have or are currently consuming Sampoerna A Mild, and live in Malang City. Measurement of the value of question items in the questionnaire ussed a Likert scale with a score of 1-5. This study used the Statistical Package for the Social Sciences (SPSS) to conduct validity test, reliability test, and classical assumption test. Data analysis techniques applied multiple linear regression tests. Hypothesis test was also carried out to test hypotheses partially and dominantly. Based on the results of hypothesis testing, the variables of promotion (X1), price (X2), and product quality (X3) each has a partially and simultance significant effect on purchase decisions with product quality (X3) as the dominant influential variable.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh promosi, harga dan kualitas produk terhadap keputusan pembelian produk rokok mild (studi konsumen pada Sampoerna A Mild di Kota Malang). Jenis penelitian ini adalah explanatory research dengan metode kuantitatif. Penelitian ini menggunakan sampel sebanyak 100 responden, Pengambilan sampel menggunakan teknik non probability sampling dengan metode purposive sampling. Kriteria responden yang dibutuhkan dalam penelitian ini adalah berusia minimal 18 tahun, pernah atau sedang mengkonsumsi Sampoerna A Mild dan berdomisili di Kota Malang. Pengukuran nilai item pertanyaan dalam kuesioner menggunakan skala likert dengan skor 1-5. Penelitian ini menggunakan Statistical Package for the Social Sciences (SPSS) untuk melakukan uji validitas, uji reliabilitas dan uji asumsi klasik. Teknik analisis data menggunakan uji regresi linear berganda. Uji hipotesis dilakukan untuk menguji hipotesis secara parsial, simultan dan dominan. Berdasarkan hasil pengujian hipotesis diperoleh data variabel promosi (X1), harga (X2), dan kualitas produk (X3) masing-masing berpengaruh signifikan secara parsial dan simultan terhadap keputusan pembelian, dengan kualitas produk (X3) sebagai variabel yang berpengaruh dominan.
Pengaruh Performance Expectancy, Service Quality, dan Social Influence Terhadap Continuance Intention
Authors: Triana Ni Made Ajeng , Arif Moh. Erfan 
Published: August 2024

LINE Webtoon, one of the big players in global webtoon industry, has been experiencing a decline in the number of its active users during the 2020-2023 period. This is an indication of Indonesian people’s decreasing continuance intention to use LINE Webtoon application. The objective of this research is to assess and corroborates the effects of performance expectancy, service quality, and social influence on the continuance intention of using LINE Webtoon application in the Special Capital Region of Jakarta. This explanatory study explains the position and the relationship of the observed variables through hypothesis testing. Using non-probability sampling method and purposive sampling technique, 114 people with the minimum age of seventeen years and have used or are using LINE Webtoon were selected as the respondents. The results of the multiple linear regression performed in SPSS 29 indicate that performance expectancy significantly influences people’s continuance intention to use LINE Webtoon, that service quality significantly affects the continuance intention, and that social influence also significantly impacts the continuance intention.

Abstrak
LINE Webtoon sebagai salah satu pemain besar di industri webtoon global mengalami penurunan jumlah pengguna aktif di Indonesia sejak tahun 2020 sampai 2023. Fenomena ini menunjukkan adanya penurunan niat berkelanjutan penggunaan aplikasi LINE Webtoon di Indonesia. Penelitian ini bertujuan untuk menguji dan menjelaskan pengaruh performance expectancy, service quality, dan social influence terhadap continuance intention penggunaan aplikasi LINE Webtoon di DKI Jakarta. Jenis penelitian ini adalah penelitian eksplanatori yang menjelaskan kedudukan dan hubungan antara variabel – variabel yang diteliti melalui pengujian hipotesis. Penelitian ini menggunakan sampel sebanyak 114 responden yang merupakan pengguna aplikasi LINE Webtoon di DKI Jakarta. Pengambilan sampel menggunakan teknik non-probability sampling dengan metode purposive sampling dengan karakteristik usia minimal 17 tahun dan pernah atau sedang menggunakan aplikasi LINE Webtoon. Penelitian ini menggunakan SPSS 29 untuk melakukan uji regresi linear berganda. Hasil penelitian menunjukkan bahwa performance expectancy berpengaruh signifikan terhadap continuance intention, service quality berpengaruh signifikan terhadap continuance intention, dan social influence berpengaruh signifikan terhadap continuance intention penggunaan aplikasi LINE Webtoon.
Pengaruh Social media Marketing dan Elctronic Word of Mouth Terhadap Purchase Intention
Authors: Orella Ryo Mahesa , Anggraeni Rila 
Published: August 2024

This study aims to determine the effect of Social Media Marketing and Electronic Word of Mouth on Purchase Intention. This research is an Explanatory Research which explains causal relationships between variables through hypothesis testing. This research used 107 respondents with purposive sampling technique. The criteria that used in this research are Bogor residents aged 15-30 years who have purchased food from Social Media and have seen Tebar Rasa's Instagram account. Data were analyzed with Statistical Package for Social Science (SPSS) ver. 26.0. The data were tested by validity and reliability test, classical assumption test, multiple linear regression analysis test and hypothesis testing. The results of this research show that Social Media Marketing and Electronic Word of Mouth have a positive and significant effect on Purchase Intention.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh social media Marketing dan Electronic Word of Mouth terhadap Purchase Intention. Jenis penelitian ini adalah explanatory research yang menjelaskan hubungan kausal antara variabel – variabel melalui pengujian hipotesis. Penelitian ini menggunakan sampel sebanyak 107 responden. Pengambilan sampel menggunakan teknik purposive sampling dengan karakteristik warga kota Bogor yang berusia 15-30 tahun, pernah membeli produk makanan melalui sosial media dan pernah melihat akun Instagram Tebar Rasa. Pengumpulan data dilakukan dengan menggunakan kuesioner. Teknik analisis data dilakukan menggunakan Statistical Package for Social Science (SPSS) ver. 26.0. Kemudian data dianalisis dengan uji validitas dan reliabilitas, uji asumsi klasik, uji analisis regresi linier berganda, dan uji hipotesis. Hasil penelitian menunjukkan bahwa social media Marketing dan Electronic Word of Mouth memiliki pengaruh yang positif dan signifikan terhadap Purchase Intention.
Pengaruh E-service quality dan E-Trust terhadap E-loyalty Pengguna Simobiplus dengan E-Satisfaction sebagai Variabel Mediasi
Authors: Ciandi Wiliam Yanto 
Published: August 2024

The increase in the transaction values and volumes of electronic money is a phenomenon showing that people tend to use electronic payment methods, such as mobile banking. Based on a survey entitled Bank Service Excellence Monitor of 2022, SimobiPlus is one of the ten best performing mobile banking of the year. However, despite the numerous awards in digital service development, users were still complaining about the service of SimobiPlus in both Appstore and Playstore, and this might affect their loyalty. The objective of this research is to analyze the effect of e-service and e-trust on the e-loyalty of SimobiPlus users through the mediation of e-satisfaction. Using non-probability sampling method and purposive sampling technique, 121 SimobiPlus users living in Malang city were selected as the samples. The results of the Partial Least Squares analysis indicate that e-service quality, e-trust, and e-satisfaction positively and significantly influence e-loyalty, that e-service quality and e-trust positively and significantly affect e-satisfaction, and that e-satisfaction significantly mediates the impact of e-service quality and e-trust on e-loyalty. This research is particularly directed to Bank Sinarmas. The fierce competition in banking industry requires Bank Sinarmas to continuously provide excellent services to its customers through serving their needs.

Abstrak
Fenomena peningkatan nilai dan volume transaksi penggunaan uang elektronik, menunjukkan masyarakat cenderung menggunakan metode pembayaran elektronik, seperti mobile banking. Disamping banyaknya penghargaan, beberapa nasabah juga memberikan komentar negatif terkait layanan SimobiPlus melalui appsstore maupun playstore. Tujuan penelitian ini adalah menganalisis pengaruh E-service quality dan E-Trust terhadap e-loyalty pengguna SimobiPlus dengan E-Satisfaction sebagai variabel mediasi. Metode analisis yang digunakan adalah analisis Partial Least Square. Penentuan sampel dalam penelitian ini menggunakan metode non-probability sampling dengan teknik purposive sampling. Sampel terdiri dari 121 pengguna SimobiPlus berdomisili Kota Malang. Hasil temuan dari studi ini menunjukkan bahwa e-service quality, E-Trust, dan E-Satisfaction secara positif dan signifikan mempengaruhi e-loyalty. E-service quality dan E-Trust secara positif dan signifikan mempengaruhi E-Satisfaction. Selain itu, penelitian ini juga menunjukkan E-Satisfaction secara signifikan memediasi pengaruh E-service quality dan E-Trust terhadap e-loyalty pengguna SimobiPlus. Implementasi dari penelitian ini lebih ditujukan untuk Bank Sinarmas. Persaingan yang ketat di industri perbankan mengharuskan Bank Sinarmas untuk selalu memberikan pelayanan prima terhadap nasabah Bank Sinarmas dalam hal melayani kebutuhan nasabah.