bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conceptus implantation and placentation: molecules related to epithelial–mesenchymal transition, lymphocyte homing, endogenous retroviruses, and exosomes
Authors: Imakawa Kazuhiko , Bai Rulan , Fujiwara Hiroshi , Kusama Kazuya 
Published: July 2015

AbstractProcesses of conceptus implantation and placentation, unique to mammalian reproduction, have been extensively studied. It was once thought that processes of these events varied greatly, notably between invasive and noninvasive modes of implantation and/or placentation. Regardless of the mode of implantation, however, physiological and biochemical processes in conceptus implantation to the maternal endometrium including the kinds of gene expression and their products are now considered not to differ so much. Recent progress has identified that in addition to the hormones, cytokines, proteases and cell adhesion molecules classically characterized, epithelial–mesenchymal transition, molecules related to lymphocyte homing, the expression of endogenous retroviruses and possibly exosomes are all required for the progression of conceptus implantation to placentation. In this review, therefore, new findings related to these events are integrated into the context of conceptus implantation to the maternal endometrium.
Brain Imaging in Gambling Disorder
Authors: Quester Saskia , Romanczuk-Seiferth Nina 
Published: July 2015

AbstractGambling disorder recently was reclassified under the category “substance-related and addictive disorders.” With regard to the diagnostic criteria, it overlaps a great deal with substance use disorder, i.e., loss of control, craving/withdrawal, and neglect of other areas of life. However, the gambling disorder symptom “chasing one’s losses” is the only criterion absent from substance use disorder. Therefore, special forms of reward (i.e., gain/loss) processing, such as the processing of loss avoidance and loss aversion, have just recently attracted attention among gambling disorder researchers. Because gambling disorder might be considered an addiction in its “pure” form, i.e., without the influence of a drug of abuse, investigating brain volume changes in people with this behavioral addiction is an important task for neuroimaging researchers in exploring the neural signatures of addiction. Because the brain is a complex network, investigation of alterations in functional connectivity has gained interest among gambling disorder researchers in order to get a more complete picture of functional brain changes in people with gambling disorder. However, only a few studies on brain structure and functional connectivity in gambling disorder have been performed so far. This review focuses on brain imaging studies of reward and loss processing, with an emphasis on loss avoidance and aversion as well as brain volume and functional connectivity in gambling disorder.
Family and school influences on adolescents' adjustment: The moderating role of youth hopefulness and aspirations for the future
Authors: Gerard Jean M. , Booth Margaret Zoller 
Published: July 2015

AbstractUsing a school‐based sample of 675 adolescents, this short‐term longitudinal investigation examined the relationships among individual, family, and school influences on adolescent adjustment problems. Adolescents' perceptions of school climate and their sense of connectedness to school were negatively associated with conduct problems. A significant interaction between parental academic support and adolescents' academic aspirations was detected for the total sample, boys, and White youth, indicating that parental support serves a protective function against conduct problems for students with low academic expectations. Adolescents' hopefulness, parental academic aspirations, and school connectedness were negatively associated with depression. Adolescents' hopefulness and their academic aspirations moderated associations between both family and school influences on adolescent adjustment with youth gender and race qualifying these interaction effects.
Shifts in the Care for Patients Presenting in Primary Care With Anxiety; Stepped Collaborative Care Parameters From More than a Decade
Authors: Gidding L.G. , Spigt M.G. , Maris J.G. , Herijgers O. , Dinant G.-J. 
Published: July 2015

AbstractBackgroundThe mental health burden on primary care is substantial and increasing. Anxiety is a major contributor. Stepped collaborative care (SCC) is implemented worldwide to improve patient outcomes, but long term real-world evaluations of SCC do not exist. Using routinely used electronic medical records from more than a decade, we investigated changes in anxiety prevalences, whether physicians made distinction between non-severe and severe anxiety, and whether these groups were referred and treated differently, both non-pharmacologically and pharmacologically.MethodsRetrospective assessment of anxiety care parameters recorded by 54 general practitioners between 2003 and 2014, in the electronic medical records of a dynamic population of 49,841–69,413 primary care patients.ResultsSubstantial shifts in anxiety care parameters have occurred. The prevalence of anxiety symptoms doubled to 0.9% and of anxiety disorders almost tripled to 1.1%. Use of ICPC codes seemed comprehensive and use of instruments to support in anxiety level differentiation increased to 13% of anxiety symptom and 7% of anxiety disorder patients in 2014. Minimal interventions were used more frequently, especially for anxiety symptoms (OR 21 [95% CI 5.1–85]). The antidepressant prescription rates decreased significantly for anxiety symptoms (OR 0.5 [95% CI 0.4–0.8]) and anxiety disorders (OR 0.6 [95% CI 0.4–0.8]). More patients were referred to psychologists and psychiatrists.ConclusionsWe found shifts in anxiety care parameters that follow the principles of SCC. Future primary care research should comprehensively assess the use of the SCC range of therapeutic options, tailored to patients with all different anxiety severity levels.
Functional Disability and Quality of Life Decrements in Mental Disorders: Results From the Mental Health Module of the German Health Interview and Examination Survey for Adults (Degs1-Mh)
Authors: Mack Simon , Jacobi Frank , Beesdo-Baum Katja , Gerschler Anja , Strehle Jens , Höfler Michael , Busch Markus A. , Maske Ulrike , Hapke Ulfert , Gaebel Wolfgang , Zielasek Jürgen , Maier Wolfgang , Wittchen Hans-Ulrich 
Published: July 2015

AbstractBackgroundThis paper provides nationally representative data on how current and past mental disorders are related to functional disability and health-related quality of life (QoL).MethodsResults are based on a nationally representative sample (DEGS1-MH; n = 4483 aged 18–79). Respondents were examined by clinical interviewers with the DSM-IV Composite International Diagnostic Interview (DIA-X/M-CIDI). Functional disability, i.e. number of disability days in the past 4 weeks, and QoL, i.e. mental (MCS) and physical (PCS) component scale of the SF-36V2, were examined in subjects with 12-month mental disorders (= active cases [AC]) and compared to (a) subjects who never met diagnostic criteria (= unaffected individuals [UAI]), and (b) those with a history of mental disorders but not meeting the diagnostic criteria in the past 12 months (= non-active cases [NAC]; partially or fully remitted).ResultsIn comparison to UAI (mean: 1.9), AC reveals a 2–3 fold disability days/month (5.4, P < .001) and a substantially reduced MCS (UAI: 52.1; AC: 43.3, P < .001). NAC had a similar number of disability days as UAI, but significantly reduced MCS scores (49.9; P < .001). Disability days and QoL decrements were highest in internalizing disorders including somatoform disorders and most pronounced in comorbid cases.ConclusionsBy and large, findings of a previous study were confirmed and extended for this nationally representative German sample. 12-month mental disorders, particularly internalizing, including somatoform disorders, are associated with high levels of disability and increased health-related QoL decrements. Partial or complete remission of the mental disorders is associated with a normalization of the numbers of disability days.
Regulatory MicroRNA Networks: Complex Patterns of Target Pathways for Disease-Related and Housekeeping MicroRNAs
Authors: Zafari Sachli , Backes Christina , Leidinger Petra , Meese Eckart , Keller Andreas 
Published: July 2015

Abstract
Blood-based microRNA (miRNA) signatures as biomarkers have been reported for various pathologies, including cancer, neurological disorders, cardiovascular diseases, and also infections. The regulatory mechanism behind respective miRNA patterns is only partially understood. Moreover, “preserved” miRNAs, i.e., miRNAs that are not dysregulated in any disease, and their biological impact have been explored to a very limited extent. We set out to systematically determine their role in regulatory networks by defining groups of highly-dysregulated miRNAs that contribute to a disease signature as opposed to preserved housekeeping miRNAs. We further determined preferential targets and pathways of both dysregulated and preserved miRNAs by computing multi-layer networks, which were compared between housekeeping and dysregulated miRNAs. Of 848 miRNAs examined across 1049 blood samples, 8 potential housekeepers showed very limited expression variations, while 20 miRNAs showed highly-dysregulated expression throughout the investigated blood samples. Our approach provides important insights into miRNAs and their role in regulatory networks. The methodology can be applied to systematically investigate the differences in target genes and pathways of arbitrary miRNA sets.
Correlating Bladder Cancer Risk Genes with their Targeting MicroRNAs using MMiRNA-Tar
Authors: Liu Yang , Baker Steve , Jiang Hui , Stuart Gary , Bai Yongsheng 
Published: July 2015

Abstract
The Cancer Genome Atlas (TCGA) (http://cancergenome.nih.gov) is a valuable data resource focused on an increasing number of well-characterized cancer genomes. In part, TCGA provides detailed information about cancer-dependent gene expression changes, including changes in the expression of transcription-regulating microRNAs. We developed a web interface tool MMiRNA-Tar (http://bioinf1.indstate.edu/MMiRNA-Tar) that can calculate and plot the correlation of expression for mRNA−microRNA pairs across samples or over a time course for a list of pairs under different prediction confidence cutoff criteria. Prediction confidence was established by requiring that the proposed mRNA−microRNA pair appears in at least one of three target prediction databases: TargetProfiler, TargetScan, or miRanda. We have tested our MMiRNA-Tar tool through analyzing 53 tumor and 11 normal samples of bladder urothelial carcinoma (BLCA) datasets obtained from TCGA and identified 204 microRNAs. These microRNAs were correlated with the mRNAs of five previously-reported bladder cancer risk genes and these selected pairs exhibited correlations in opposite direction between the tumor and normal samples based on the customized cutoff criterion of prediction. Furthermore, we have identified additional 496 genes (830 pairs) potentially targeted by 79 significant microRNAs out of 204 using three cutoff criteria, i.e., false discovery rate (FDR) &lt; 0.1, opposite correlation coefficient between the tumor and normal samples, and predicted by at least one of three target prediction databases. Therefore, MMiRNA-Tar provides researchers a convenient tool to visualize the co-relationship between microRNAs and mRNAs and to predict their targeting relationship. We believe that correlating expression profiles for microRNAs and mRNAs offers a complementary approach for elucidating their interactions.
A Two-Dimensional Problem for a Rotating Magneto-Thermoelastic Half-Space with Voids and Gravity in a Two-Temperature Generalized Thermoelasticity Theory
Authors: Deswal S. , Hooda N. 
Published: July 2015

ABSTRACTThe present paper is concerned with an in-depth study of the effects of rotation, two-temperature parameter and voids on the magneto-thermoelastic interactions in a homogeneous, isotropic, generalized half-space with gravity field. The formulation is applied within the frame-work of two-temperature generalized thermoelasticity based on the hyperbolic heat conduction model with one relaxation time. Using normal mode analysis technique for the physical variables appearing in the governing equations, we get the analytical expressions for displacement components, stress, thermodynamic temperature, conductive temperature and change in volume fraction field. The general solution obtained is then applied to a specific problem of an infinite half-space having isothermal boundary subjected to mechanical load. Variations of the considered variables through the vertical distance are illustrated graphically.
Loci of complex polynomials, part II: polar derivatives
Authors: SENDOV BLAGOVEST , SENDOV HRISTO 
Published: July 2015

AbstractFor every complex polynomialp(z), closed point sets are defined, calledlociofp(z). A closed set Ω ⊆${\mathbb C}$* is a locus ofp(z) if it contains a zero of any of its apolar polynomials and is the smallest such set with respect to inclusion. Using the notion locus, some classical theorems in the geometry of polynomials can be refined. We show that each locus is a Lebesgue measurable set and investigate its intriguing connections with the higher-order polar derivatives ofp.
Computing with relational machines
Authors: HUET GÉRARD , RAZET BENOÎT 
Published: July 2015

We propose a relational computing paradigm based on Eilenberg machines, an effective version of Eilenberg's X-machines suitable for general non-deterministic computation. An Eilenberg machine generalizes a finite-state automaton, seen as its control component, with a computation component over a data domain specified as a relational algebra, its actions being interpreted as binary relations over the data domain. We show various strategies for the sequential simulation of our relational machines, using variants of thereactive engine. In a particular case offinite machines, we show that bottom-up search yields an efficient complete simulator.Relational machines may be composed in a modular fashion, since atomic actions of one machine can be mapped to the characteristic relation of other relational machines acting as its parameters.The control components of machines can be compiled from regular expressions. Several such translations have been proposed in the literature, which we briefly survey.
SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation
Authors: Tang Leo T. -H. , Craig Tim J. , Henley Jeremy M. 
Published: July 2015

AbstractSynapsins are key components of the presynaptic neurotransmitter release machinery. Their main role is to cluster synaptic vesicles (SVs) to each other and anchor them to the actin cytoskeleton to establish the reserve vesicle pool, and then release them in response to appropriate membrane depolarization. Here we demonstrate that SUMOylation of synapsin Ia (SynIa) at K687 is necessary for SynIa function. Replacement of endogenous SynIa with a non-SUMOylatable mutant decreases the size of the releasable vesicle pool and impairs stimulated SV exocytosis. SUMOylation enhances SynIa association with SVs to promote the efficient reclustering of SynIa following neuronal stimulation and maintain its presynaptic localization. The A548T mutation in SynIa is strongly associated with autism and epilepsy and we show that it leads to defective SynIa SUMOylation. These results identify SUMOylation as a fundamental regulator of SynIa function and reveal a novel link between reduced SUMOylation of SynIa and neurological disorders.
Sodium and Lithium Storage Properties of Spray-Dried Molybdenum Disulfide-Graphene Hierarchical Microspheres
Authors: Kalluri Sujith , Seng Kuok Hau , Guo Zaiping , Du Aijun , Konstantinov Konstantin , Liu Hua Kun , Dou Shi Xue 
Published: July 2015

AbstractDeveloping nano/micro-structures which can effectively upgrade the intriguing properties of electrode materials for energy storage devices is always a key research topic. Ultrathin nanosheets were proved to be one of the potential nanostructures due to their high specific surface area, good active contact areas and porous channels. Herein, we report a unique hierarchical micro-spherical morphology of well-stacked and completely miscible molybdenum disulfide (MoS2) nanosheets and graphene sheets, were successfully synthesized via a simple and industrial scale spray-drying technique to take the advantages of both MoS2 and graphene in terms of their high practical capacity values and high electronic conductivity, respectively. Computational studies were performed to understand the interfacial behaviour of MoS2 and graphene, which proves high stability of the composite with high interfacial binding energy (−2.02 eV) among them. Further, the lithium and sodium storage properties have been tested and reveal excellent cyclic stability over 250 and 500 cycles, respectively, with the highest initial capacity values of 1300 mAh g−1 and 640 mAh g−1 at 0.1 A g−1.
Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment
Authors: Checa Antonio , Xu Ning , Sar Daniel G. , Haeggström Jesper Z. , Ståhle Mona , Wheelock Craig E. 
Published: July 2015

AbstractSphingolipids are bioactive molecules with a putative role in inflammation. Alterations in sphingolipids, in particular ceramides, have been consistently observed in psoriatic skin. Herein, we quantified the circulating sphingolipid profile in individuals with mild or severe psoriasis as well as healthy controls. In addition, the effects of anti-TNF-α treatment were determined. Levels of sphingoid bases, including sphingosine-1-phosphate (S1P), increased in severe (P < 0.001; n = 32), but not in mild (n = 32), psoriasis relative to healthy controls (n = 32). These alterations were not reversed in severe patients (n = 16) after anti-TNF-α treatment despite significant improvement in psoriasis lesions. Circulating levels of sphingomyelins and ceramides shifted in a fatty acid chain length-dependent manner. These alterations were also observed in psoriasis skin lesions and were associated with changes in mRNA levels of ceramide synthases. The lack of S1P response to treatment may have pathobiological implications due to its close relation to the vascular and immune systems. In particular, increased levels of sphingolipids and especially S1P in severe psoriasis patients requiring biological treatment may potentially be associated with cardiovascular comorbidities. The fact that shifts in S1P levels were not ameliorated by anti-TNF-α treatment, despite improvements in the skin lesions, further supports targeting S1P receptors as therapy for severe psoriasis.
The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase
Authors: Le Meur Rémy , Culard Françoise , Nadan Virginie , Goffinont Stéphane , Coste Franck , Guerin Martine , Loth Karine , Landon Céline , Castaing Bertrand 
Published: July 2015

The nucleoid-associated protein HU is involved in numerous DNA transactions and thus is essential in DNA maintenance and bacterial survival. The high affinity of HU for SSBs (single-strand breaks) has suggested its involvement in DNA protection, repair and recombination. SSB-containing DNA are major intermediates transiently generated by bifunctional DNA N-glycosylases that initiate the BER (base excision repair) pathway. Enzyme kinetics and DNA-binding experiments demonstrate that HU enhances the 8-oxoguanine-DNA glycosylase activity of Fpg (formamidopyrimidine-DNA glycosylase) by facilitating the release of the enzyme from its final DNA product (one nucleoside gap). We propose that the displacement of Fpg from its end-DNA product by HU is an active mechanism in which HU recognizes the product when it is still bound by Fpg. Through DNA binding, the two proteins interplay to form a transient ternary complex Fpg/DNA/HU which results in the release of Fpg and the molecular entrapment of SSBs by HU. These results support the involvement of HU in BER in vivo.
Klotho expression is reduced in COPD airway epithelial cells: effects on inflammation and oxidant injury
Authors: Gao Wei , Yuan Cheng , Zhang Jingying , Li Lingling , Yu Like , Wiegman Coen H. , Barnes Peter J. , Adcock Ian M. , Huang Mao , Yao Xin 
Published: July 2015

COPD (chronic obstructive pulmonary disease) is associated with sustained inflammation, excessive injury, and accelerated lung aging. Human Klotho (KL) is an anti-aging protein that protects cells against inflammation and damage. In the present study, we quantified KL expression in the lungs of COPD patients and in an ozone-induced mouse model of COPD, and investigated the mechanisms that control KL expression and function in the airways. KL distribution and levels in human and mouse airways were measured by immunohistochemistry and Western blotting. The effect of CSE (cigarette smoke extract) on KL expression was detected in human bronchial epithelial cells. Moreover, the effect of KL on CSE-mediated inflammation and hydrogen peroxide-induced cellular injury/apoptosis was determined using siRNAs. KL expression was decreased in the lungs of smokers and further reduced in patients with COPD. Similarly, 6 weeks of exposure to ozone decreased KL levels in airway epithelial cells. CSE and TNFα (tumour necrosis factor α) decreased KL expression and release from airway epithelial cells, which was associated with enhanced pro-inflammatory cytokine expression. Moreover, KL depletion increased cell sensitivity to cigarette smoke-induced inflammation and oxidative stress-induced cell damage. These effects involved the NF-κB (nuclear factor κB), MAPK (mitogen-activated protein kinase) and Nrf2 (nuclear factor erythroid 2-related factor 2) pathways. Reduced KL expression in COPD airway epithelial cells was associated with increased oxidative stress, inflammation and apoptosis. These data provide new insights into the mechanisms associated with the accelerated lung aging in COPD development.
Hearing Aid–Induced Plasticity in the Auditory System of Older Adults: Evidence From Speech Perception
Authors: Lavie Limor , Banai Karen , Karni Avi , Attias Joseph 
Published: July 2015

PurposeWe tested whether using hearing aids can improve unaided performance in speech perception tasks in older adults with hearing impairment.MethodUnaided performance was evaluated in dichotic listening and speech-in-noise tests in 47 older adults with hearing impairment; 36 participants in 3 study groups were tested before hearing aid fitting and after 4, 8, and 14 weeks of hearing-aid use. The remaining 11 participants served as a control group and were similarly evaluated but were not fitted with hearing aids. Three protocols were compared in the study groups: amplification for the nondominant ear, amplification for the dominant ear, and bilateral amplification. Subsequently, after 4 weeks, all participants were afforded bilateral amplification.ResultsIn the study groups, unaided dichotic listening scores improved significantly in the nondominant ear by 8 weeks and onward. Significant improvements were also observed for unaided speech identification in noise, with some gains apparent after 4 weeks of hearing-aid use. No gains were observed in the control group.ConclusionsUsing hearing aids for a relatively short period can induce changes in the way older adults process auditory inputs in perceptual tasks such as speech identification in noise and dichotic listening. These changes suggest that the central auditory system of older adults retains the potential for behaviorally relevant plasticity.