bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications of thrombolysis in an intensive care unit
Authors: Deimantavičienė Živilė , Klimas Nerijus , Pečkauskas Aurimas , Bakšytė Giedrė , Macas Andrius , Pieteris Linas , Repšienė Aurelija 
Published: October 2012

Background. Thrombolysis is often the only way in treating people with life-threatening conditions, like acute myocardial infarction (AMI), pulmonary embolism (PE) and acute ischemic stroke (AIS). Complications of thrombolytic therapy are not rare and have clear influence in the quality of life, hospital stay, outcomes and mortality. Most common complications are intracranial hemorrhage, severe injection site, nose, vaginal bleeding and peripheral hematomas. Methods and materials. A retrospective study took place in the Department of Intensive Care, Hospital of Lithuanian University of Health Sciences Kaunas Clinics. Medical data of 83 patients, who underwent treatment with thrombolytic drugs in the period of 2007–2011, were analyzed. All patients were treated with intravenous infusion of Alteplase. Inclusion criteria were as follows: • AMI, AIS or PE treatable with thrombolytic therapy. Results. 72.3% (n = 60) of patients experienced massive PE, 13.3% (n = 11) AMI and 14.4% (n = 12) AIS. There were 8.43% (n = 7) of patients who had bleeding complications – 2.4% (n = 2) experienced nose bleed during or shortly after thrombolytic therapy, 3.6% (n = 3) had injection site bleeding and 1.2% (n = 1) experienced multiple skin hemorrhages. 11.7% (n = 7) of patients in the group of massive PE were thrombolised during CPR and only one of them experienced bleeding to the pleural cavity. There were no internal or external bleeding observed neither in AMI nor in AIS groups. In-hospital mortality after thrombolytic therapy was 20.5% (n = 17). Conclusions. Thrombolytic therapy very often is the only way in treating acute, life-threatening diseases, like acute myocardial infarction, pulmonary embolism or acute ischemic stroke. Intracranial hemorrhage, injection site, nose, vaginal bleeding and peripheral hematomas are the most common complications of thrombolysis. Risk factors should be evaluated before starting the thrombolytic therapy. Data of our hospital experience do not dramatically differ from worldwide data.
Distinguishing Between Darts and Arrows in the Archaeological Record: Implications for Technological Change in the American West
Authors: Hildebrandt William R. , King Jerome H. 
Published: October 2012

AbstractWe propose a new method for differentiating archaeological atlatl darts from arrow points. Our dart-arrow index accurately distinguishes known (hafted) archaeological examples of darts and arrows. We find that ethnographic collections of hafted arrows used by previous researchers are problematic, and should not be used as control samples for differentiating darts from arrows. We use the dart-arrow index to reassess the projectile points described by Ames et al. (2010). The analysis shows that Hatwai Eared (4400–2800 B.P.) and Cascade (8500–4500 B.P.) points were darts, not arrows as Ames et al. argue, and that a major revision of the history of bow-and-arrow technology in western North America is unnecessary.
Décrochage, raccrochage et rétention scolaires selon les Jeunes franco-ontariens
Authors: Michaud Jacques , Boissonneault Julie , Côté Daniel , Tremblay Cindy-Lynne , Allaire Gratien 
Published: October 2012

L’article présente les résultats d’une recherche menée dans les écoles de langue française de l’Ontario sur le décrochage de l’école secondaire, en soulignant le phénomène du « décrochage culturel », selon lequel les jeunes quittent l’école de langue française pour poursuivre leurs études en anglais. À partir du point de vue de jeunes qui vivent, qui ont vécu ou qui sont à risque de vivre le décrochage, les auteurs illus­trent la complexité de cette question dans une perspective multi­factorielle et multidimensionnelle.
Dérives spatiales et mouvances langagières : les romanciers contemporains et l’Amérique canadienne-française
Authors: Morency Jean 
Published: October 2012

Dans cet article, Jean Morency étudie la survivance dans le roman québécois contemporain de la culture du Canada français, une culture caractérisée par sa relation particulière à l’espace nord-américain et sa remarquable mobilité géographique. Après avoir présenté les principales stratégies visant à inscrire le roman québécois dans le tissu géographique, social, culturel, linguistique et littéraire nord-américain, l’auteur tente de retracer, sur la base d’une hypothèse de nature psychosociale qu’il nomme le « retour de l’identité refoulée canadienne-française », les modes de filiation établis entre quelques romanciers contemporains (Michel Tremblay, Jacques Poulin et Nicolas Dickner) et un certain imaginaire de l’Amérique canadienne-française.
Au-delà de l’école : le projet politique de l’autonomie culturelle1
Authors: Landry Rodrigue 
Published: October 2012

Nous introduisons ici le concept d’autonomie culturelle. Après l’avoir défini et en avoir décrit les composantes, nous analysons trois défis que doivent relever les communautés francophones et acadiennes soucieuses d’acquérir une autonomie culturelle réelle. Les institutions éducatives deviennent la pierre angulaire d’un processus de prise en charge institutionnelle qui circonscrit leur projet politique d’autonomie culturelle. Le premier défi consiste à viser « au-delà de l’article 23 » en vue d’assurer le développement global et relativement complet des institutions éducatives de langue française, lequel englobe non seulement les écoles publiques, mais aussi les services à la petite enfance et l’éducation postsecondaire. Le deuxième défi consiste à viser « au-delà de la diglossie », ce qui signifie que s’il faut faire du français une langue publique dans les institutions, il est tout autant impératif d’assurer une « proximité socialisante » en français qui puisse favoriser la transmission intergénérationnelle de la langue. Enfin, nous exposons dans leurs grandes lignes certains défis d’aménagement linguistique liés au Plan d’action pour les langues officielles du gouvernement fédéral.
Construction identitaire francophone en milieu minoritaire canadien : « Qui suis-je ? », « Que suis-je ? »
Authors: Deveau Kenneth 
Published: October 2012

En cherchant à se doter d’une identité sociale positive, les personnes tendent à adopter des identités multiples, variées et complexes, produits de leur socialisation et expressions de leur construction personnelle. Compte tenu de cette complexité, une conception de l’identité ethnolinguistique orientée uniquement sur l’autodéfinition ne tient pas compte de la valeur ni de la signification de l’identité. Nous avons alors proposé une conceptualisation de l’identité ethnolinguistique comportant deux composantes en interaction : l’autodéfinition et l’engagement identitaire. Dans le présent article, deux questions – « Qui suis-je ? » et « Que suis-je ? » – guident l’analyse de ces deux composantes de l’identité francophone et de leur processus de construction en situation francophone minoritaire au Canada. Sont pris en compte divers aspects de la socialisation ethnolangagière.
Pratiques langagières et discours sur les langues et l’identité dans une entreprise montréalaise : contradictions et ajustements
Authors: Lamarre Patricia , Lamarre Stéphanie 
Published: October 2012

Ce texte examine les pratiques langagières et les discours sur la langue et l’identité dans une entreprise montréalaise de postproduction en pleine expansion. Les données nous révèlent un milieu où le français domine, mais où des stratégies sont mises en place pour gérer la communication bilingue ou multilingue. Malgré cette zone tampon (buffer zone), il devient apparent que le bilinguisme est une réalité pour la majorité des employés, même s’ils utilisent l’anglais de façon ponctuelle. De plus, nous constatons que le bilinguisme est présent à plusieurs niveaux de l’entreprise et pas seulement aux échelons les plus élevés de la hiérarchie. Dans les discours des employés, nous constatons des tensions et des contradictions au sujet du bilinguisme, décrit comme une ressource importante sur les plans individuel et collectif (le Québec), mais aussi comme une menace à la vitalité de la langue française. D’autres tensions dans les discours se trouvent dans la perception des législations visant la promotion et la protection de la langue française : cette politique est vue comme bénéfique pour le projet linguistique et culturel du Québec, mais aussi comme un obstacle de plus pour le positionnement économique du Québec sur un marché mondialisé.
Identité ethnolinguistique, autodétermination et satisfaction de vie en contexte francophone minoritaire
Authors: Landry Rodrigue , Deveau Kenneth , Losier Gaëtan F. , Allard Réal 
Published: October 2012

L’étude a pour objet de vérifier empiriquement la validité d’un modèle théorique qui propose un système de relations liant la construction de l’identité ethnolinguistique à la satisfaction de vie, un aspect du mieux-être psychologique, et à l’autoévaluation de sa santé. Un échantillon de 8 124 élèves du secondaire, provenant de 30 conseils scolaires francophones situés à l’extérieur du Québec, a participé à l’étude. Les résultats sont conformes au modèle fondé sur la théorie de l’autodétermination, qui stipule que lorsque la construction identitaire se fait dans un contexte d’appui à des besoins psychologiques de base, elle est reliée au mieux-être psychologique de la personne.
Du mouvement et de la variation du Tout-monde chez Édouard Glissant
Authors: Uwe Christian 
Published: October 2012

Le concept de Tout-monde semble être le point de convergence de la pensée d’Édouard Glissant. Les nombreuses définitions qu’en donne l’auteur participent d’une pensée en mouvement, toujours et volontiers recommencée, une pensée dont l’expression embrasse jusqu’aux formes qu’elle emprunte et qui fait de l’imaginaire un trait d’union entre la poétique et l’éthique. L’idée de mouvement, inscrite dans l’approche du Tout-monde, éclaire ainsi le caractère foncièrement inachevé d’un monde dont il s’agit de penser la complexité et qui se donne à la fois comme « quantité réalisée » et comme projet.
Le développement des communautés francophones vivant en situation minoritaire : les effets du contexte sur ses représentations en Ontario et au Nouveau-Brunswick
Authors: Normand Martin 
Published: October 2012

La notion de développement se retrouve généralement dans les débats sur les langues officielles au Canada. Comment les différents acteurs communautaires se représentent-ils cette notion ? Ce texte propose que les représentations du développement découlent des effets structurants du contexte plus global du débat sur les langues officielles au Canada. Après un survol de l’évolution du débat sur le développement, ce texte vérifie les effets du Plan d’action pour les langues officielles, compris comme une institution qui à la fois structure l’action de la société civile et qui lui procure des ressources, sur les représentations du développement véhiculées par l’Assemblée de la francophonie de l’Ontario et par la Société des Acadiens et Acadiennes du Nouveau-Brunswick. Dans les deux cas, les représentations du développement semblent influencées par l’action du gouvernement fédéral dans le domaine des langues officielles.
Electrocoagulative Surgical Procedure for Treatment of Conjunctivochalasis
Authors: Zhang Xing-Ru , Zhang Zhen-Yong , Hoffman Matthew R 
Published: October 2012

Abstract
The purpose of this study was to present a new procedure to treat symptomatic conjunctivochalasis (CCh) and to evaluate its efficacy. Forty-two patients with symptomatic CCh refractory to medical management were included on this study. Twenty-two patients (n  =  32, eyes; n  =  14 women and n  =  8 men) underwent the new electrocoagulation procedure (Group I). Twenty patients (n  =  27 eyes; n  =  11 women and n  =  9 men) underwent crescent-shaped conjunctiva resection (Group II). Ocular Surface Disease Index (OSDI) was used to evaluate ocular symptoms. There was a significant difference in mean and SD operation time between Group I (8.67 ± 2.07 minutes) and Group II (20.45 ± 3.98 minutes; P &lt; 0.0001). OSDI scores (mean ± SD) were significantly lower in Group I (28.38 ± 3.14) than Group II (31.62 ± 3.17) at postoperative week 2 (P  =  0.0004). No differences in OSDI scores were found between the 2 groups at postoperative week 4 (P  =  0.1749) or 8 (P  =  0.1483). OSDI scores were significantly lower at postoperative week 8 than at baseline in both Group I (P  =  0.0002) and Group II (P  =  0.0011). Electrocoagulation of the conjunctiva can successfully treat symptomatic CCh with earlier symptomatic attenuation and less operation time than traditional conjunctiva resection.
Deep Venous Thrombosis in Spine Surgery Patients: Incidence and Hematoma Formation
Authors: Al-Dujaili Thair M. , Majer Catalin N. , Madhoun Tarek E. , Kassis Sebouh Z. , Saleh Alaa A. 
Published: October 2012

Abstract
Deep venous thrombosis (DVT) is a significant health care problem; a variety of factors place spinal surgery patients at high risk for DVT. Our aim is to define the incidence of DVT occurrence in spite of prophylactic measures (mechanical and chemoprophylaxis), and the development of spinal epidural hematoma as a complication of chemoprophylaxis. In a single-center prospective study, 158 patients who underwent spinal surgical procedures were evaluated by clinical evaluation and lower limb Doppler ultrasonography imaging. Only one patient (0.6%) developed DVT; this patient was treated successfully without thrombus progression, with full recanalization. Three patients (1.8%) developed spinal epidural hematoma, but only one required surgical evacuation, and none sustained neurologic deficit. Careful evaluation for DVT risk on an individual basis and good prophylaxis helps to minimize the risk of DVT. The neurosurgeon is thus left to weigh the risks of postoperative hematoma formation against the benefits of protecting against DVT.
Malignant Phyllodes Tumors of the Breast: A Study in Clinical Practice
Authors: Majeski James , Stroud Jason 
Published: October 2012

AbstractMalignant phyllodes tumors are an uncommon breast tumor in clinical practice of surgery. The study population consisted of five consecutive patients. Each patient had complete clinical follow-up with annual mammograms and physical examination in a specialized breast clinic. They were surgically treated for with malignant phyllodes tumor of the breast. All patients are alive and well with a complete follow-up. The first 2 patients had a fine needle aspiration cytology and were surgically treated by a simple mastectomy. The remaining 3 patients were preoperatively diagnosed with core needle biopsy. These 3 patients were treated with a wide excision of the phyllodes tumor with at least a 1-cm margin of normal breast tissue. Mammography was 100% accurate in demonstrating a dense breast mass. In each patient ultrasound suggested heterogeneous internal echoes present in each malignant phyllodes tumor. Fine needle aspiration cytology was of no value in the diagnosis of a phyllodes tumor. Core needle biopsy is highly reliable in establishing a preoperative diagnosis. The most helpful clinical observation of a malignant phyllodes tumor was rapid growth and enlargement, which is frequently noted by the patient.
Missense mutations in the ABCB6 transporter cause dominant familialpseudohyperkalemia
Authors: Andolfo Immacolata , Alper Seth L. , Delaunay Jean , Auriemma Carla , Russo Roberta , Asci Roberta , Esposito Maria Rosaria , Sharma Alok K. , Shmukler Boris E. , Brugnara Carlo , De Franceschi Lucia , Iolascon Achille 
Published: October 2012

AbstractFamilial Pseudohyperkalemia (FP) is a dominant red cell trait characterized by increased serum [K+] in whole blood stored at or below room temperature, without additional hematological abnormalities. Functional gene mapping and sequencing analysis of the candidate genes within the 2q35–q36 critical interval identified—in 20 affected individuals among three multigenerational FP families—two novel heterozygous missense mutations in the ABCB6 gene that cosegregated with disease phenotype. The two genomic substitutions altered two adjacent nucleotides within codon 375 of ABCB6, a porphyrin transporter that, in erythrocyte membranes, bears the Langereis blood group antigen system. The ABCB6 R375Q mutation did not alter the levels of mRNA or protein, or protein localization in mature erythrocytes or erythroid precursor cells, but it is predicted to modestly alter protein structure. ABCB6 mRNA and protein levels increase during in vitro erythroid differentiation of CD34+ erythroid precursors and the erythroleukemia cell lines HEL and K562. These data suggest that the two missense mutations in residue 375 of the ABCB6 polypeptide found in affected individuals of families with chromosome 2‐linked FP could contribute to the red cell K+ leak characteristic of this condition. Am. J. Hematol. 2013. © 2012 Wiley Periodicals, Inc.
ANK3 as a risk gene for schizophrenia: New data in han Chinese and meta analysis
Authors: Yuan Aihua , Yi Zhenghui , Wang Qiang , Sun Jinhua , Li Zhiqiang , Du Yasong , Zhang Chen , Yu Tao , Fan Juan , Li Huafang , Yu Shunying 
Published: October 2012

AbstractHistological and neuroimaging evidence supports the hypothesis that neuronal disconnectivity may be involved in the pathogenesis of schizophrenia. A genome‐wide association study (GWAS) showed a single nucleotide polymorphism (SNP), rs10761482 in ankyrin 3 (ANK3), a major neuron‐enriched gene, was associated with schizophrenia although inconsistent results had been reported. Two meta analyses reported another SNP rs10994336 in ANK3 gene confers risk to bipolar disorder (BD). Due to evidence of genetic overlap between schizophrenia and BD, we investigated common findings by analyzing the association of ANK3 polymorphisms (rs10761482, rs10994336, and two missenses, rs3808942 and rs3808943) with schizophrenia, using the Han Chinese population. A total of 516 schizophrenia cases, 400 controls, and 81 trios of early onset schizophrenia were recruited for association studies. Furthermore, the published datasets were combined with our results to determine the effect of the loci on schizophrenia. Our association study showed the frequencies of C allele of rs10761482 and T allele of rs10994336 were higher in patients than in controls. Furthermore, allele condition analyses indicated the association signal observed at rs10761482 and rs10994336 was independent. A haplotype analysis revealed the rs10761482–rs3808942–rs3808943 haplotype was associated with schizophrenia. The frequency of the T–T–T haplotype was higher in patients than in controls. In the transmission disequilibrium test analysis, the C allele of rs10761482 and the rs10761482–rs3808942–rs3808943 haplotype were preferentially transmitted in the trios. Meta analysis incorporating previous and current studies also showed rs10761482 and rs10994336 were associated with schizophrenia. We conclude that ANK3 gene has a major influence on susceptibility to schizophrenia across populations. © 2012 Wiley Periodicals, Inc.
Coping and the biosocial consequences of food insecurity in the 21st century
Authors: Hadley Craig , Crooks Deborah L. 
Published: October 2012

AbstractFood security occurs when all members of a household have reliable access to food in sufficient quantity and quality to maintain an active and healthy lifestyle. Given the important biological and social value of food for humans, food and food sufficiency have been traditional topics of study among biological anthropologists. The focus on food insecurity, however, has emerged within the past two decades and recent global events, including the food crisis of 2007/2008, have led to renewed interests in the topic of food insecurity and wellbeing. Here, we review current and novel threats to food security, current thinking on measurement and definitions, and then outline a model that links food insecurity to coping strategies and then to health outcomes. We suggest that coping strategies are typically context‐specific and can be food and nonfood based. We further suggest that coping strategies may impact health quite broadly, not just through nutritional pathways. We then review available data on the relationship between food insecurity and nutritional status, chronic diseases, infectious diseases, and mental health. Our review highlights the far reaching consequences of food insecurity for human wellbeing but also the considerable variability in its effect and our limited empirical knowledge of the pathways through which food insecurity impacts health. We conclude by offering thoughts on how biological anthropologists might contribute to growing our understanding of food insecurity and human health and wellbeing. Am J Phys Anthropol, 2012. © 2012 Wiley Periodicals, Inc.
Determining the best graft‐sealant combination for skull base repair using a soft tissue in vitro porcine model
Authors: Fandiño Marcela , Macdonald Kristian , Singh Devin , Whyne Cari , Witterick Ian 
Published: October 2012

BackgroundThe purpose of this work was to compare the absolute breaking strength of various soft tissue skull base (SB) repairs in an in vitro porcine model.MethodsA burst pressure (BP) testing system was designed using an axial loading force to create increasing hydraulic pressure. Defects measuring 0.5 × 0.5 cm were created in fascia lata samples. Defects were repaired using various grafts (pericranium and 2 different dural substitutes, Alloderm® and Durasis®) measuring 1.0 × 1.0 cm to cover the deficient area. Grafts were further reinforced onto the fascia background with either fibrin glue (Tisseel®) or hydrogel sealant (DuraSeal™). Each combination of graft and sealant was conducted 6 times and tested 24 hours after the repair.ResultsThe mean BP (±standard deviation [SD]) were as follows: DuraSeal™‐Alloderm, 12.5 ± 5.8 mmHg; DuraSeal™‐Durasis, 21.8 ± 20.7 mmHg; DuraSeal™‐pericranium, 44.7 ± 30.1 mmHg; Tisseel‐Alloderm, 30.6 ± 26.3 mmHg; Tisseel‐Durasis, 15.8 ± 18.6 mmHg; and Tisseel‐pericranium, 95.5 ± 86 mmHg. One‐way analysis of variance showed that the strongest type of repair was Tisseel‐pericranium when adjusting for the others (p < 0.0001). The difference in mean BP of repair with DuraSeal™ vs Tisseel® was not statistically significant (p = 0.22). Comparing sealants, the use of Alloderm® or Durasis® decreased the strength of the repair in comparison to pericranium (p < 0.0001). Bonferroni analysis showed a significant difference between pericranium and Alloderm® (p < 0.05) and between pericranium and Durasis® (p < 0.05) but not between Alloderm® and Durasis® (p > 0.05).ConclusionIn this model, the strongest type of repair (pressure 6 times higher than normal intracranial pressure) was the combination of Tisseel®‐pericranium. Our data will help guide surgeons who repair SB defects to choose the best graft and sealant.