bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 842: Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor
Authors: Grotmol Tom , Kristiansen Wenche , Karlsson Robert , Rounge Trine B. , Whitington Thomas , Andreassen Bettina K. , Magnusson Patrik KE , Adami Hans-Olov , Turnbull Clare , Haugen Trine B. , Wiklund Fredrik 
Published: August 2015

Abstract
Genome-wide association (GWA) studies have reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT). The aim of the present study was to identify additional loci and gene sets associated with susceptibility to TGCT. A GWA study for TGCT was performed by genotyping 610,240 single nucleotide polymorphisms (SNPs) in 1,326 cases and 6,687 controls from Sweden and Norway. We put forward 34 SNPs from 17 novel regions and 11 SNPs previously reported, for replication in 710 case-parent triads and 289 cases and 290 controls. Predefined biological pathways and processes, in addition to a custom-built sex determination gene set, were subject to enrichment analyses using Meta-Analysis Gene Set Enrichment of Variant Associations (M) and Improved Gene Set Enrichment Analysis for Genome-wide Association Study (I). In the combined meta-analysis, we observed genome-wide significant association for rs7501939 on chromosome 17q12 (OR = 1.29, 95% CI = 1.19-1.40, P = 1.1 × 10-9) and rs2195987 on chromosome 19p12 (OR = 1.31, 95% CI: 1.19-1.45, P = 3.2 × 10-8). The marker rs7501939 on chromosome 17q12 is located in an intron of the HNF1B gene, encoding a member of the homeodomain-containing superfamily of transcription factors. The sex determination gene set (FDRM &lt; 0.001, FDRI &lt; 0.001) and pathways related to NF-κB, glycerophospholipid and ether lipid metabolism, as well as cancer and apoptosis, was associated with TGCT (FDR &lt; 0.1). In addition to revealing two new TGCT susceptibility loci, our results support the notion that genes governing normal germ cell development in utero are implicated in the development of TGCT.
Citation Format: Tom Grotmol, Wenche Kristiansen, Robert Karlsson, Trine B. Rounge, Thomas Whitington, Bettina K. Andreassen, Patrik KE Magnusson, Hans-Olov Adami, Clare Turnbull, Trine B. Haugen, Fredrik Wiklund. Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 842. doi:10.1158/1538-7445.AM2015-842
Abstract 849: The changing role of GDF15 (growth/differentiation factor 15) during prostate carcinogenesis
Authors: Rybicki Benjamin A. , Chitale Dhananjay , Gupta Nilesh , Jackson LaToya , Wheeler Travis , Trudeau Sheri , Jankowski Michelle , Bobbittt Kevin , Rundle Andrew , Tang Delian 
Published: August 2015

Abstract
GDF15 (growth/differentiation factor 15) is a divergent member of the TGFβ superfamily of cytokines and is highly expressed in prostate tumors, but its role in prostate carcinogenesis and utility as a prognostic biomarker is unclear. We studied 58 prostate cancer cases (35 Whites and 23 African Americans) that underwent surgery as their primary treatment and were then subsequently followed for biochemical recurrence (BCR). In these cases, which also had a benign prostate biopsy at least one year before their prostate cancer diagnosis, we quantified GDF15 expression in their pre-malignant benign prostate, prostate tumor and tumor adjacent benign prostate tissue. GDF15 expression levels were analyzed for association with high grade prostate cancer and BCR. Twenty-six percent of cases had high grade cancer defined as Gleason score 8 or higher or a Gleason score of 7 and a primary Gleason of 4. During follow-up, 11 cases (19%) experienced BCR (80 percent of men without BCR had at least 2 years of follow-up). GDF15 expression was not associated high grade cancer in any prostate tissue types. GDF15 expression was associated with BCR, but the direction of the association was dependent upon the type of prostate tissue expression measured. Evidence of GDF15 expression in pre-malignant benign prostate was associated with an almost 9-fold increased risk of BCR (Hazard Ratio (HR) = 8.90; 95% confidence interval (CI) = 1.09-72.49), even after adjusting for race, tumor grade and stage. When we stratified men into low and high expression groups, we also found a significant gradient of risk with increased GDF15 expression (p = 0.03). The opposite was found for GDF15 expression in tumor tissue, where men with low GDF15 expression had a decreased risk of BCR (HR = 0.30; 95% CI = 0.06- 1.59), and men with high GDF15 expression were at an even lower risk (HR = 0.10; 95% CI = 0.02-0.61). Expression of GDF15 in tumor adjacent benign prostate tissue was not associated with BCR. The role GDF15 plays in prostate carcinogenesis is complex and may change during the course of tumor development. Our results suggest GDF15 exerts a pro-tumorgenic effect very early in prostate carcinogenesis, but later after the tumor becomes clinically apparent, GDF15 may act more in an anti-tumorgenic manner.
Citation Format: Benjamin A. Rybicki, Dhananjay Chitale, Nilesh Gupta, LaToya Jackson, Travis Wheeler, Sheri Trudeau, Michelle Jankowski, Kevin Bobbittt, Andrew Rundle, Delian Tang. The changing role of GDF15 (growth/differentiation factor 15) during prostate carcinogenesis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 849. doi:10.1158/1538-7445.AM2015-849
Abstract 851: Characteristics of adult men who are willing to give HPV vaccine to their daughters in the United States: a national survey
Authors: Rogers Jessica , Idowu Kolapo A. , Coker Rahmatalai , Segunmaru Hamidat , Daremipouran Mohammad , Burnside Clinton , Williams Carla D. , Laiyemo Adeyinka O. 
Published: August 2015

Abstract
Background: The uptake of Human Papillomavirus (HPV) vaccination needs improvement. However, efforts to improve uptake of HPV vaccine is often concentrated on women. Although men can influence the uptake of the vaccine by their children, the opinion of adult men in the United States on HPV vaccination has not been well studied.
Aim: To evaluate the willingness of adult men to vaccinate their daughters for HPV
Methods: Health Information National Trends Survey (HINTS) 2007 was used to capture the opinion of 1,927 men (weighted population size = 72,633,670) who answered questions on their willingness to let their daughters receive HPV vaccine. We compared the characteristics of those who were willing to let their daughters receive HPV vaccine with those who were not. We used survey weights in all analyses, and variance estimations were performed using Taylor series linearization to account for the complex survey design. We used logistic regression models to calculate odds ratios (OR) and 95% confidence intervals (CI).
Results: A total of 1,554 (80.7%) men were willing to let their daughters receive HPV vaccine while 373 (19.3%) would not let their daughters receive the vaccine. The most common reasons for disagreeing with vaccination were: not knowing enough about it (27.7%); vaccine safety concerns (16.5%); and “my child is not sexually active” (13.7%). Of note, less than 1% felt the vaccine will promote promiscuity. Demographic (age, race, marital status, education status, and health insurance) and lifestyle characteristics (smoking and body mass index) did not predict men who would let their daughters get HPV vaccine.
Conclusion: A high percentage of men are willing to let their daughters receive HPV vaccine suggesting that all men should be engaged in the conversation to improve HPV vaccine uptake in the United States. Primary care physicians should make it a priority to discuss the HPV vaccine with men and women more frequently to enlighten the population and allay their fears about the safety of the vaccine.
Citation Format: Jessica Rogers, Kolapo A. Idowu, Rahmatalai Coker, Hamidat Segunmaru, Mohammad Daremipouran, Clinton Burnside, Carla D. Williams, Adeyinka O. Laiyemo. Characteristics of adult men who are willing to give HPV vaccine to their daughters in the United States: a national survey. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 851. doi:10.1158/1538-7445.AM2015-851
Abstract 856: Correlation of prognosis and histologic patterns by the IASLC/ATS/ERS classification in invasive pulmonary adenocarcinoma: A meta-analysis
Authors: Park Keon Uk , Kim Jin Young , Ryoo Hun Mo , Hwang Ilseon 
Published: August 2015

Abstract
Background: Invasive pulmonary adenocarcinoma is composed of five histologic patterns including lepidic, papillary, acinar, solid, and micropapillary patterns by the International Association for the Study of Lung Cancer, the American Thoracic Society, and the European Respiratory Society classification. Many researches for histologic pattern and survival rates were performed, but confirmative relationships of histologic pattern and patient's prognosis are unclear. Methods: We searched PubMed using the keywords “IASLC/ATS/ERS classification” and “International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society”. Review articles and case reports were excluded, and duplicated data, insufficient data, and overlapping articles are also excluded. The pooled analysis was performed with the Comprehensive Meta-analysis Software version 2.0. Results: Lepidic predominant pattern had significantly lower recurrence and expire than acinar, papillary, solid or micropapillary pattern. Acinar or papillary pattern had significantly lower recurrence and expire than solid or micropapillary pattern. Conclusions: Invasive adenocarcinoma with lepidic predominant pattern has better prognosis than that with the other predominant patterns. Acinar and papillary predominant patterns have better prognosis than solid and micropapillary predominant patterns in invasive pulmonary adenocarcinoma. There are no different prognoses between acinar and papillary predominant patterns, and solid and micropapillary predominant patterns of invasive pulmonary adenocarcinoma.
Citation Format: Keon Uk Park, Jin Young Kim, Hun Mo Ryoo, Ilseon Hwang. Correlation of prognosis and histologic patterns by the IASLC/ATS/ERS classification in invasive pulmonary adenocarcinoma: A meta-analysis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 856. doi:10.1158/1538-7445.AM2015-856
Abstract 860: Effects of breastfeeding and oral contraception use on the risk of breast cancer recurrence: A multinational study
Authors: Lehman Teresa A. , Shaik Mohammed , Modali Ramakrishna V. , Hrinczenko Borys 
Published: August 2015

Abstract
Introduction:
Breastfeeding (BF) decreases and oral contraceptive (OCP) increases the incidence of breast cancer (BC). However, their role in the recurrence of breast cancer (rBC) has not been established. The aim of our study was to examine the association of maternal factors in the rBC.
Methods:
Data were obtained from the Global Epidemiological Study (GES), an IRB approved multinational biorepository and database to assess disease risk factors. Pts provided their personal history, age, BMI, age of first pregnancy, BF, number of children breastfed, radiation exposure (RE), years of OCP use, benign breast disease (BD), hysterectomy, hormone replacement therapy (HRT) and rBC. The t-test and chi-square test were used for continuous and categorical variables, respectively. The association [adjusted odds ratio (aOR)] between rBC and each risk factor was obtained using logistic regression after adjusting for all the variables including stage of cancer.
Results:
A total of 2546 patients were surveyed, of which 218 patients had rBC later in life. The average age of pts with recurrence was 54 yrs and those without rBC was 56 yrs. Of the total, 73.5% had BF, 25% had used OCP, 17.3% used HRT, 5.6% had RE, 16.6% had a hysterectomy, and 16% had BD. In multivariate analysis, age, BF, OCP and RE each had significant impacts on the rBC. Pts who did not BF had a 3-fold increased risk of recurrence compared to those who breastfed at least 3 children [aOR of 2.9 (1.7-4.9)]. Pts who did not use OCPs were 53% less likely to have rBC compared to those who used OCPs [aOR of 0.47 (0.32-0.69)]. A statistically significant dose-effect for number of children breastfed and rBC, and years of OCPs usage and rBC was found. BMI, HRT, hysterectomy, BD, and age at first pregnancy did not have an effect on rBC.
Conclusion: Our study suggests that breastfeeding decreases the risk of recurrence of breast cancer, while OCP usage increases the risk of recurrence of breast cancer. Further studies are needed to validate our results.
Predictors of recurrence of breast cancer (rBC)Variablesβ EstimateAdjusted OR (CI)p-valueAge0.0221.02 (1.008-1.03)0.002Breastfed (BF, none vs. &gt;3 children)1.062.9 (1.7-4.9)&lt;0.0001Breastfed (BF, &lt; 3 vs. &gt; 3 children)0.742.09 (1.2-3.5)0.006Oral Contraceptive use (OCP, no vs. yes)-0.7430.47 (0.32-0.69)0.0001Radiation exposure (RE, no vs. yes)-1.310.26 (0.16- 0.13)&lt;0.0001HRT (no vs. yes)0.41.49 (0.96-2.3)0.07
Citation Format: Teresa A. Lehman, Mohammed Shaik, Ramakrishna V. Modali, Borys Hrinczenko. Effects of breastfeeding and oral contraception use on the risk of breast cancer recurrence: A multinational study. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 860. doi:10.1158/1538-7445.AM2015-860
Abstract 867: Reproductive factors and risk of B-cell non-Hodgkin lymphoma among women in Los Angeles
Authors: Lu Yani , Luo Jianning , Wang Sophia , Sullivan-Halley Jane , Cozen Wendy , Bernstein Leslie 
Published: August 2015

Abstract
Background: Overall, non-Hodgkin lymphoma (NHL) incidence is higher in men than women, and the male to female ratio differs by NHL subtype. Historically, female reproductive characteristics and patterns have been inconsistently linked to NHL risk, though studies on this topic remain limited. Because a woman experiences changes in immune function during pregnancy, that permit her to establish and maintain a successful pregnancy, we hypothesize that such pregnancy-associated changes in immune function could affect the risk of NHL, a cancer of the immune cells.
Methods: We conducted a population-based case-control study among women in Los Angeles County comprising 998 histologically confirmed B-cell NHL patients diagnosed 2004-2008 from the Los Angeles Cancer Surveillance Program and 998 individually matched controls (matched on age, race and socioeconomic status). Conditional logistic regression was used to calculate the associations [odds ratios (OR) and 95% confidence intervals (CI)] between female reproductive factors (e.g., ever pregnant; number of full-term pregnancies; breastfeeding) with B-cell NHL overall and unconditional logistic regression was used to calculate the associations with major NHL subtypes.
Results: Compared to women who had never been pregnant, women who had full-term pregnancies had 17% decreased risk of B-cell NHL (OR = 0.83, 95% CI = 0.64-1.08); the decreased risk was most pronounced for the diffuse large B-cell lymphoma (DLBCL) subtype (OR = 0.68, 95% CI = 0.47-0.98). Increasing number of full-term pregnancies was inversely associated with B-cell NHL overall (P-trend = 0.02), DLBCL (P-trend = 0.03) and follicular lymphoma (P-trend = 0.04). Women who had reported breastfeeding also had decreased risk of B-cell NHL overall (OR = 0.80, 95% CI = 0.64-1.00) and follicular lymphoma (OR = 0.71, 95% CI = 0.50-1.00). Among women who had full-term pregnancies, women who breastfed for 60 weeks or more had 30% decreased risk of B-cell NHL overall (OR = 0.70, 95% CI = 0.52-0.93; P-trend = 0.06), which was consistent for follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).
Conclusions: Our results provide evidence for an association between female reproductive factors and decreased risk of B-cell NHL, supporting a role for hormonal factors in B-cell NHL etiology.
Citation Format: Yani Lu, Jianning Luo, Sophia Wang, Jane Sullivan-Halley, Wendy Cozen, Leslie Bernstein. Reproductive factors and risk of B-cell non-Hodgkin lymphoma among women in Los Angeles. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 867. doi:10.1158/1538-7445.AM2015-867
Abstract 869: Body mass index, weight gain, and physical activity during adulthood in relation to colorectal cancer risk
Authors: Tu Huakang , Pu Xia , Daniel-MacDougall Carrie , Melkonian Stephanie C. , Ye Yuanqing , Raju Gottumukkala S. , Kopetz Scott , Wu Xifeng 
Published: August 2015

Abstract
Background: The impact of obesity/overweight, weight gain, and physical activity during adulthood on colorectal cancer (CRC) risk is not clear. To examine the associations between body mass index (BMI), weight gain, and physical activity during adulthood and CRC risk, we conducted a case-control study of incident CRC.
Methods: Incident CRC case subjects were recruited from the University of Texas MD Anderson Cancer Center in Houston, Texas; healthy control subjects without a history of cancer, except non-melanoma skin cancer, were identified and recruited using random digit dialing. Epidemiologic data were collected by in-person interview. Unconditional logistic regression and regression spline were performed to obtain odds ratios (ORs). All statistical tests were two-sided.
Results: A total of 524 non-Hispanic white case subjects and 1,053 healthy control subjects who were 40 years or older were included. In multivariate analysis, obesity (BMI ≥ 30) and overweight (BMI between 25 and 30) at age 20 years were significantly associated with a 2.4-fold (OR = 2.39, 95% confidence interval [CI] = 1.38 - 4.13, P = .002) and 1.6-fold (OR = 1.60, 95% CI = 1.19 - 2.14, P = .002) increased risk of CRC, respectively. Similarly, obesity and overweight at age 40 years were each significantly associated with a 2.1-fold (OR = 2.11, 95% CI = 1.49 - 2.99, P &lt; .0001) and 1.7-fold (OR = 1.74, 95% CI = 1.32 - 2.30, P &lt; .0001) increased risk of CRC. In addition, moderate and massive weight gain from age 20 to 40 years were associated with increased CRC risks, although this increase did not reach statistical significance. Moderate physical activity was significantly associated with a reduced risk of CRC (OR = 0.60, 95% CI = 0.44 - 0.81, P = .001).
Conclusions: Obesity/overweight and physical activity during adulthood may influence susceptibility to CRC; also, our data suggest that weight gain during childhood and adolescence may play a more important role than weight gain during adulthood in CRC development.
Citation Format: Huakang Tu, Xia Pu, Carrie Daniel-MacDougall, Stephanie C. Melkonian, Yuanqing Ye, Gottumukkala S. Raju, Scott Kopetz, Xifeng Wu. Body mass index, weight gain, and physical activity during adulthood in relation to colorectal cancer risk. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 869. doi:10.1158/1538-7445.AM2015-869
Abstract 870: Physical activity, diet and ovarian cancer risk
Authors: Lehman Teresa A. , Modali Ramakrishna V. , Ratnasinghe Luke 
Published: August 2015

Abstract
Physical activity and diet are modifiable risk factors for most cancers. Previous studies of the association between physical activity, diet and ovarian cancer risk have yielded mixed results. We evaluated the association between physical activity, diet and ovarian cancer risk among 578 ovarian cancer cases and 7188 non-cancer controls in the Global Epidemiology Study (GES). The GES is linked to the Global Repository that houses biomaterial. For ovarian cancer, newly diagnosed subjects provided informed consent and were asked about physical activity and diet during in-person interviews. The multivariate-adjusted odds ratio (OR) was 0.6 (95% confidence interval (95% CI): 0.5-0.8) for women who reported physical activity greater than 160 minutes per week after adjusting for age, race, BMI and pack-years of smoking compared to women who reported less than 30 minutes of physical activity. Women who were in the highest tertile of vegetables consumers were at 20% reduced risk for ovarian cancer compared to the lowest tertile [OR:0.8, 95% CI: 0.6-0.9]. Individuals who were in the highest tertile of dairy consumers were at 40% reduced risk for ovarian cancer compared to the lowest tertile [OR: 0.6, 95% CI: 0.5-0.8]. For meat consumption, individuals who were in the highest tertile were at 60% increased risk for ovarian cancer compared to the lowest tertile [OR: 1.6, 95% CI: 1.3-2.0]. Results from our study suggest that physical activity and diet are modifiable risk factors for ovarian cancer.
Citation Format: Teresa A. Lehman, Ramakrishna V. Modali, Luke Ratnasinghe. Physical activity, diet and ovarian cancer risk. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 870. doi:10.1158/1538-7445.AM2015-870
Abstract 871: The association between periodontal disease and pancreatic cancer
Authors: Chang Jeffrey S. , Tsai Chia-Rung , Shan Yan-Shen , Chen Li-Tzong 
Published: August 2015

Abstract
Background: Despite years of research, the causes of pancreatic cancer have remained largely unknown. Periodontal disease (PD) is an emerging risk factor for various systemic diseases, including cancer. The current study investigated the association between PD (periodontitis, gingivitis, and others) and development of pancreatic cancer.
Methods: Using data from the National Health Insurance Research Database of Taiwan, 139,805 subjects with PD and 75,085 subjects without PD were identified. The association between PD and pancreatic cancer was assessed using Cox proportional hazards regression model.
Results: Having PD was associated with a higher pancreatic cancer risk (hazard ratio (HR) = 1.55, 95% confidence interval (CI): 1.02-2.33). The higher pancreatic cancer risk associated with PD was observed among those aged 65 years or older (HR = 2.17, 95% CI: 1.03-4.57) and but not among those aged younger than 65 years (HR = 0.83, 95% CI: 0.52-1.34). Further analysis showed that PD remained an independent risk factor for pancreatic cancer after adjusting for diabetes, hyperlipidemia, allergies, viral hepatitis, peptic ulcer, pancreatitis, COPD (as a proxy for cigarette smoking) and alcoholic-related conditions (as a proxy for alcohol drinking).
Conclusions: Our analysis showed a significantly positive association between PD and pancreatic cancer risk. Further investigation is needed to explain the underlying biological mechanisms for the positive association between PD and pancreatic cancer.
Citation Format: Jeffrey S. Chang, Chia-Rung Tsai, Yan-Shen Shan, Li-Tzong Chen. The association between periodontal disease and pancreatic cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 871. doi:10.1158/1538-7445.AM2015-871