bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibody-Mediated Immune Suppression of Erythrocyte Alloimmunization Can Occur Independently from Red Cell Clearance or Epitope Masking in a Murine Model
Authors: Yu Honghui , Stowell Sean R. , Bernardo Lidice , Hendrickson Jeanne E. , Zimring James C. , Amash Alaa , Uchikawa Makoto , Lazarus Alan H. 
Published: August 2014

Abstract
Anti-D can prevent immunization to the RhD Ag on RBCs, a phenomenon commonly termed Ab-mediated immune suppression (AMIS). The most accepted theory to explain this effect has been the rapid clearance of RBCs. In mouse models using SRBC, these xenogeneic cells are always rapidly cleared even without Ab, and involvement of epitope masking of the SRBC Ags by the AMIS-inducing Ab (anti-SRBC) has been suggested. To address these hypotheses, we immunized mice with murine transgenic RBCs expressing the HOD Ag (hen egg lysozyme [HEL], in sequence with ovalbumin, and the human Duffy transmembrane protein) in the presence of polyclonal Abs or mAbs to the HOD molecule. The isotype, specificity, and ability to induce AMIS of these Abs were compared with accelerated clearance as well as steric hindrance of the HOD Ag. Mice made IgM and IgG reactive with the HEL portion of the molecule only. All six of the mAbs could inhibit the response. The HEL-specific Abs (4B7, IgG1; GD7, IgG2b; 2F4, IgG1) did not accelerate clearance of the HOD-RBCs and displayed partial epitope masking. The Duffy-specific Abs (MIMA 29, IgG2a; CBC-512, IgG1; K6, IgG1) all caused rapid clearance of HOD RBCs without steric hindrance. To our knowledge, this is the first demonstration of AMIS to erythrocytes in an all-murine model and shows that AMIS can occur in the absence of RBC clearance or epitope masking. The AMIS effect was also independent of IgG isotype and epitope specificity of the AMIS-inducing Ab.
A pilot study on expression of toll like receptors (TLRs) in response to herpes simplex virus (HSV) infection in acute retinal pigment epithelial cells (ARPE) cells
Authors: Moses S , Jambulingam M , Madhavan HN 
Published: August 2014

Introduction:
Toll like receptors (TLRs) have been proven to play an important role in mounting the innate immune response in an infected host. The expression of TLRs against herpes simplex virus (HSV) have not been studied in retinitis. Therefore, the current study was undertaken to determine the same using the retinal pigment epithelial (ARPE-19) cell line.

Materials and Methods:
APRE cells cultured in vitro were challenged with HSV 1 and 2 standard strains and 20 other clinical isolates. The cells were observed for cytopathic changes. The cell culture harvest was subjected to RNA extraction using a Total RNA mini kit. The RNA was subjected to reverse transcriptase polymerase chain reaction (PCR) for the amplification of TLRs 3, 4 and 9 and GAPDH housekeeping gene. The amplified products were subjected to electrophoresis on a 2% agarose gel and viewed under a transilluminator.

Results:
TLR 3 and 4 were expressed by ARPE treated with all the 22 isolates. TLR 9 expression was seen in 16 of the 22 isolates. Bacterial contamination was ruled out by subjecting the harvests to PCR amplification of 16sRNA gene amplification of the eubacterial genome.

Conclusions:
The expression of TLR 4 has been reported for the first time in HSV infection. TLR 4 along with TLR 3 and 9 is responsible for the antiviral response in HSV infections.
A prospective study of prevalence and association of peripheral neuropathy in Indian patients with newly diagnosed type 2 diabetes mellitus
Authors: Gill HK , Yadav SB , Ramesh V , Bhatia E 
Published: August 2014

Background:
Diabetic peripheral neuropathy (DPN) predisposes to foot ulceration and gangrene. It has been reported that DPN is lower in Indians relative to Caucasians. Studies among recent onset patients with type 2 diabetes mellitus (T2DM) are very few. We studied the prevalence and risk factors of DPN in patients with newly diagnosed T2DM.

Materials and Methods:
We prospectively studied 195 consecutive patients over age 30 with a duration of diabetes ≤6 months. All underwent a clinical and biochemical evaluation and were screened for DPN using Neuropathy Symptom Score (NSS) and Neuropathy Disability Score (NDS) as well as the vibration perception threshold using a biothesiometer. We compared the prevalence of peripheral neuropathy (PN) in 75 age- and sex-matched healthy controls.

Results:
The cases had a mean age of 47.6 ± 10.2 years (59% males) and duration of symptoms of 5.9 ± 8.2 months prior to presentation. The overall prevalence of DPN was 29.2% [95% CI 22.8-35.7]. PN among matched control was 10.7% (95% CI 3.5-17.8). The prevalence of DPN showed an increasing trend with age (trend chi-square 11.8, P = 0.001). Abnormal vibration perception threshold was present in 43.3% (95% CI 36.3-50.3) of cases and had a significant correlation with NDS (P = 0.000). Abnormal monofilament testing was present in 6.1% of cases (95% CI 2.7- 9.5). A logistic regression analysis showed that DPN was independently associated with age (P = 0.002) and duration of diabetes prior to presentation (P = 0.02) but not with body mass index, plasma glucose, or HbA1c.

Conclusions:
Our study showed high prevalence of PN in recently diagnosed patients with T2DM, which was independently associated with age and duration of symptoms of diabetes prior to the diagnosis. Screening for DPN at diagnosis of diabetes is warranted, especially among older subjects.
Prevalence of gastro-esophageal reflux disease in patients with difficult to control asthma and effect of proton pump inhibitor therapy on asthma symptoms, reflux symptoms, pulmonary function and requirement for asthma medications
Authors: Sandur V , Murugesh M , Banait V , Rathi PM , Bhatia SJ , Joshi JM , Kate A 
Published: August 2014

Background:
The hypothesis that GER can trigger or exacerbate asthma is supported by several clinical trials that have shown amelioration in asthma symptoms and/or an improvement in pulmonary function after antireflux therapy.

Aims:
To investigate the prevalence of GER in patients with difficult to control asthma and to determine the effect of omeprazole on asthma symptoms, reflux symptoms, pulmonary function and on the requirement of asthma medications.

Materials and Methods:
Patients with difficult to control asthma were recruited into the study. All patients underwent esophageal manometry and 24 hour esophageal pH monitoring. Pulmonary function tests were done before and after treatment. The severity of asthma and reflux was assessed by a 1 week pulmonary symptom score(PSS) and reflux symptom score(RSS) respectively before and after treatment. Those who had an abnormal pH study (pH <4 in the distal esophagus for >5% of the time) underwent anti-GER treatment with lifestyle changes, and a proton pump inhibitor (omeprazole 40 mg, bid) for 3 months. Asthma medications were added or deleted based on severity of asthma.

Results:
Out of 250 asthmatic patients screened, forty patients fulfilled the inclusion criteria. Twenty eight of 40 patients(70%) were diagnosed to have GERD. Of the patients 28 with GER, 8 patients(28.5%) had no reflux symptoms. On 24 hr pH metry, the percentage time pH <4.0 was 10.81 ± 4.72 and 1.11 ± 1.21; Deemester score was 37.65 ± 14.54 and 4.89 ± 6.39 (p-value is 0.0001) in GERD and non-GERD patients respectively. In GERD group, post treatment reflux symptom score(RSS) improved from 22.39 ± 14.99 to 1.04 ± 1.07, pulmonary symptom score(PSS) improved from27.14 ± 7.49 to 13.82 ± 4.21and night time asthma symptom score(NASS) improved from 6.71 ± 1.80 to 3.04 ± 1.23 (p-value <0.0001). After treatment, FEV1 and PEFR increased from 1.38 ± 0.57 and 4.14 ± 1.97 to 1.47 ± 0.54 and 5.56 ± 1.72, respectively (p-value 0.00114).

Conclusions:
PPI therapy improves nocturnal asthma symptoms, daytime asthma symptoms, pulmonary function and decreases requirement of asthma medications in these patients.
Perspective:
Authors: Ewing Chatham 
Published: August 2014

ABSTRACT
This article looks at Perspective, an academic quarterly that was privately funded and had major influence in the development of the canon in American literature. After giving a history of Perspective, the article uses statistical analysis, network diagramming, and network analysis to understand the shifting taste in the creation of the canon. There is more work that can be done in the field, and new technologies and programs may shed light on this issue.
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Authors: Murphy J. Stephen , Gaipa Mark 
Published: August 2014

ABSTRACT
Taking their cue from the recommendation systems of Amazon and Netflix, which use networks of like-minded customers to suggest new titles to users, the authors investigate how networks in little magazines a hundred years ago helped readers navigate an overloaded literary market by recommending to them a taste for modernism. Focusing on The Freewoman, The New Freewoman and The Egoist—and drawing on data generated by the Modernist Journals Project—this essay shows how authors in these magazines' review and co-appearance networks became increasingly well-connected, and appeared more frequently, as the magazines became more modernistic and exclusive over time.
The Convenience Yield and the Informational Content of the Oil Futures Price
Authors: Bernard Jean-Thomas , Khalaf Lynda , Kichian Maral , McMahon Sebastien 
Published: August 2014

Recent studies have shown that futures prices do not generally outperform naive no-change forecasts of spot prices, calling into question the usefulness of futures prices for forecasting purposes. However, such usefulness is predicated on the question of whether certain modeling strategies are able to yield more of the information found in futures prices. Applying a forecast-based approach, we study the extent to which alternative ways of modeling futures prices can reveal the extent of the information present in futures prices. Using weekly and monthly data, and futures of maturities of one to four months, we notably examine the out-of-sample predictability of futures prices over various forecast horizons, and in real-time, whereby parameters are updated prior to each sequential forecast. Our results with weekly data are particularly interesting. We find that models allowing for a time-varying convenience yield often produce considerably more precise forecasts over the three forecast horizons considered. Thus, more of the informational content of futures prices is attainable when both the price level and the distance of the latter from spot price are jointly considered, rather than when only the price level is considered. We also document that forecast performances improve with longer date-to-maturity futures, suggesting that the role of the convenience yield is greater when physical oil inventories are held for longer durations. Finally, we show that forecast accuracy is highest at the one year horizon, though the time-varying convenience models have a much higher accuracy than unit-root-based models even over the three and five-year horizons.
Communication, cognition et créativité dans les sociétés de la connaissance. À propos de deux dilemmes
Authors: Ancori Bernard 
Published: August 2014

L’histoire des sciences et l’analyse bibliométrique suggèrent que les sciences de la nature, les sciences de l’ingénieur et, dans une moindre mesure, les sciences médicales seraient entrées depuis une trentaine d’années dans un régime d’équilibre stationnaire. Le but de cet article est d’identifier l’une des causes possibles d’une telle situation, et de proposer une solution efficace pour y remédier. Cette cause pourrait en effet tenir au privilège conféré, depuis le début des années 1970 et surtout depuis le milieu des années 1990, à la communication sociale au détriment de la cognition individuelle ou collective. Quant à la solution efficace pour y remédier, elle consisterait à développer systématiquement dans certains domaines des collaborations de recherche entre le monde académique et les mondes non académiques. Pour le montrer, nous procédons en deux étapes. La première met en évidence l’existence de deux dilemmes liés en ce qui concerne la structure et l’évolution d’un réseau sociocognitif complexe d’acteurs individuels : le dilemme entre créativité globale du réseau et proximités individuelles des acteurs, et celui qui se pose à chacun de ces derniers, dans chaque état du réseau, entre communiquer et cogiter. La seconde étape résume rapidement l’évolution des sciences et des technologies occidentales vers une techno-science dont la créativité semble s’essouffler, puis montre que la généralisation de forums hybrides pourrait redonner un surcroît de vigueur à cette créativité aujourd’hui atone.
Échanges, contrats et diversité des cultures
Authors: d’Iribarne Philippe 
Published: August 2014

La théorie économique des contrats suppose que leur conception et leur mise en oeuvre sont indépendantes du contexte culturel. Or, ce que les acteurs ont en tête quand ils passent des « contrats » diffère d’un pays à l’autre, en fonction de la conception d’une bonne manière de vivre et de travailler ensemble qui y prévaut. Nous en donnerons trois exemples : la variété des rapports entre une banque de développement et ses clients; la manière dont une entreprise présente ses relations avec ses clients en France et aux États-Unis; les relations entre clients et fournisseurs dans les rapports entre entreprises chinoises. Nous verrons en outre que la place qu’occupe la référence contractuelle dans le fonctionnement des entreprises et des économies est intimement liée à la vision de la société dont est porteuse la culture américaine.
Ultra‐thick Triassic dolomites control the rupture behavior of the central Apennine seismicity: Evidence from magnetic modeling of the L'Aquila fault zone
Authors: Speranza Fabio , Minelli Liliana 
Published: August 2014

AbstractHigh‐resolution tomography from the 2009 L'Aquila extensional seismic sequence has shown that the Mw 6.1 main shock and most of the aftershocks occurred within a high velocity body (6.6 ≤ Vp ≤ 6.8 km/s), located between depths of 3 and 12 km. The nature of the high‐Vp body has remained speculative, although exhumed mafic deep crustal and upper mantle rocks (serpentinites) have been favored. We used 3D magnetic anomaly modeling to investigate the plausibility of these favored sources for the L'Aquila body. The modeling does not support the presence of high‐velocity serpentinites with a 30–50% serpentinization degree and gabbros. Accordingly, we conclude that the high‐Vp body may represent non‐magnetic upper Triassic and possibly lower Liassic dolomites that have been drilled in neighboring wells for 2–4 km. This conclusion is also consistent with the lack of a coherent gravity anomaly for the body. We speculate that ultra‐thick Triassic dolomites reaching a thickness of 8 km may have been deposited in syntectonic wedges formed at the northern margin of the Ionian Sea, where oceanic spreading occurred in mid‐late Triassic times.
Occupational injuries in Ohio wood product manufacturing: A descriptive analysis with emphasis on saw‐related injuries and associated causes
Authors: Beery Lindsay , Harris James R. , Collins James W. , Current Richard S. , Amendola Alfred A. , Meyers Alysha R. , Wurzelbacher Steven J. , Lampl Mike , Bertke Stephen J. 
Published: August 2014

AbstractBackgroundStationary sawing machinery is often a basic tool in the wood product manufacturing industry and was the source for over 2,500 injury/illness events that resulted in days away from work in 2010.MethodsWe examined 9 years of workers' compensation claims for the state of Ohio in wood product manufacturing with specific attention to saw‐related claims. For the study period, 8,547 claims were evaluated; from this group, 716 saw‐related cases were examined.ResultsThe sawmills and wood preservation sub‐sector experienced a 71% reduction in average incidence rate and an 87% reduction in average lost‐time incidence rate from 2001 to 2009. The top three injury category descriptions for lost‐time incidents within saw‐related claims were fracture (35.8%), open wounds (29.6%), and amputation (14.8%).ConclusionsFor saw‐related injuries, preventing blade contact remains important but securing the work piece to prevent kickback is also important. Am. J. Ind. Med. 57:1265–1275, 2014. © 2014 Wiley Periodicals, Inc.
The Allergies, Immunotherapy, and RhinoconjunctivitiS (AIRS) survey: provider practices and beliefs about allergen immunotherapy
Authors: Leatherman Bryan , Skoner David P. , Hadley James A. , Walstein Nicole , Blaiss Michael S. , Dykewicz Mark S. , Craig Timothy , Smith Nancy , Allen‐Ramey Felicia 
Published: August 2014

BackgroundThe practices and beliefs of the provider specialties that treat allergic rhinoconjunctivitis (ARC) with allergen immunotherapy (AIT) may vary.MethodsA telephone survey of 500 randomly selected health care practitioners in 7 specialties, conducted in 2012.ResultsAIT was provided as a subcutaneous injection (SCIT) by 91% of allergist/immunologists, 54% of otolaryngologists, and 18% to 24% of other specialties. Otolaryngologists were the most frequent providers of sublingual drops of AIT (SLIT; 33%), compared to 2% to 10% of other specialties. AIT was recommended for adults with allergic rhinoconjunctivitis by 100% of allergist/immunologists vs 62% to 84% of the other specialties (p < 0.001). The primary reason for recommending AIT for adults (52%) or children (46%) was that other therapies did not work. Between 48% (nurse practitioners/physician assistants) and 93% (allergist/immunologists) of practitioners always or often decreased symptomatic medications over the course of AIT treatment. Most practitioners in all specialties (82–100%) thought that AIT was appropriate for patients with severe allergy symptoms. Significantly more allergist/immunologists and otolaryngologists than other specialists thought AIT was appropriate for mild allergy symptoms (p < 0.001 and p = 0.004, respectively, vs other specialties). Significantly more allergist/immunologists than other specialists thought that AIT was more effective than symptomatic medications (p < 0.001), could reduce the further development of allergies (p = 0.03), and could prevent the development of asthma.ConclusionSCIT was more frequently provided than SLIT by all the specialties. Otolaryngologists were the most likely to offer SLIT, while very few allergist/immunologists offered SLIT. Allergist/immunologists differed from other specialties in some beliefs about the effectiveness of AIT.
Pentacoordinate Phosphorus in a High‐Pressure Polymorph of Phosphorus Nitride Imide P4N6(NH)
Authors: Baumann Dominik , Schnick Wolfgang 
Published: August 2014

AbstractCoordination numbers higher than usual are often associated with superior mechanical properties. In this contribution we report on the synthesis of the high‐pressure polymorph of highly condensed phosphorus nitride imide P4N6(NH) representing a new framework topology. This is the first example of phosphorus in trigonal‐bipyramidal coordination being observed in an inorganic network structure. We were able to obtain single crystals and bulk samples of the compound employing the multi‐anvil technique. γ‐P4N6(NH) has been thoroughly characterized using X‐ray diffraction, solid‐state NMR and FTIR spectroscopy. The synthesis of γ‐P4N6(NH) gives new insights into the coordination chemistry of phosphorus at high pressures. The synthesis of further high‐pressure phases with higher coordination numbers exhibiting intriguing physical properties seems within reach.
Asymmetric Michael Addition/Intramolecular Cyclization Catalyzed by Bifunctional Tertiary Amine–Squaramides: Construction of Chiral 2‐Amino‐4H‐chromene‐3‐Carbonitrile Derivatives
Authors: Gao Yu , Du Da‐Ming 
Published: August 2014

AbstractThe efficient asymmetric Michael addition/intramolecular cyclization of malononitrile with dienones catalyzed by a chiral bifunctional tertiary amine–squaramide catalyst for the synthesis of chiral 2‐amino‐4H‐chromene‐3‐carbonitrile derivatives was developed. The corresponding products were obtained in good to excellent yields (up to 99 %) with excellent enantioselectivities (up to 98 % ee) for most of the bisarylidenecyclopentanones.
A Comparative Study on the Electrodeposition of Tin from Two Different Ionic Liquids: Influence of the Anion on the Morphology of the Tin Deposits
Authors: Giridhar Pulletikurthi , Elbasiony Amr M. , Zein El Abedin Sherif , Endres Frank 
Published: August 2014

AbstractThe electrodeposition of tin from two ionic liquids (ILs) containing the 1‐butyl‐1‐methylpyrrolidinium cation ([Py1,4]+) and the trifluoromethylsulfonate (TfO−) or dicyanamide (DCA−) anion is investigated by cyclic voltammetry, scanning electron microscopy (SEM), infrared (IR) spectroscopy and X‐ray diffraction. Cyclic voltammetry is employed to evaluate the electrochemical behaviour of SnCl2 in the two ILs, and IR spectroscopy is used to study the difference in the complexation of SnCl2 in the two ILs. The electrodeposition of tin is also studied in [EMIm]DCA ([EMIm]+=1‐ethyl‐3‐methylimidazolium), for the purpose of comparison. The morphology of the electrodeposited tin from the different ILs is investigated by SEM, which shows that the morphology of the tin deposits changes upon changing the IL. Agglomerated tin deposits are obtained on gold and copper from [Py1,4]TfO. Tin dendrites were obtained both from [Py1,4]DCA and [EMIm]DCA. This study reveals that a change in the ionic composition (anion) of the IL can influence the morphology of electrodeposits of tin and presumably of other elements and compounds.
A Differential Scanning Calorimetry and Theoretical Study on the Isomerization of trans‐[Co(cyclam)(ONO)2]X (X = PF6–, ClO4–)
Authors: Eslami Abbas , Hasani Nahid , Yeganegi Saeed 
Published: August 2014

AbstractThe solid‐state interconversion of trans‐[Co(cyclam)(ONO)2]X (X = PF6–, ClO4–; cyclam = 1,4,8,11‐tetraazacyclotetradecane, [14]aneN4; dinitrito isomer) and trans‐[Co(cyclam)(NO2)2]X (dinitro isomer) was investigated by differential scanning calorimetry (DSC). The conversion of the dinitrito isomer to the dinitro isomer was accompanied by the appearance of exothermic peaks. However, no isomerization DSC peak was observed for the dinitro isomers. The observed DSC peak for the dinitrito isomer was resolved into two peaks that correspond to two isomerization stages. The low‐temperature peak was ascribed to the conversion of the metastable dinitrito isomer to an unstable nitro–nitrito one, whereas the high‐temperature peak was attributed to the subsequent conversion of the nitro–nitrito isomer to the dinitro isomer. The kinetic parameters of the isomerization were determined by the Kissinger method. The electronic structures and thermodynamic stabilities of the linkage isomers, as well as the nature of the transition states, were investigated by DFT.
Synthesis and Characterization of Cationic Synphos‐Rhodium Complexes
Authors: Meißner Antje , Drexler Hans‐Joachim , Keller Sonja , Selle Carmen , Ratovelomanana‐Vidal Virginie , Heller Detlef 
Published: August 2014

AbstractDifferent types of cationic Rh complexes bearing the Synphos ligand were characterized by NMR and X‐ray analysis for the first time. This set of compounds includes diolefin rhodium precursors [Rh(Synphos)(cod)]BF4 and [Rh(Synphos)(nbd)]BF4, solvate complexes [Rh(Synphos)(MeOH)2]BF4, [Rh(Synphos)(acetone)2]BF4 as well as the toluene complex [Rh(Synphos)(toluene)]BF4, trinuclear complexes [Rh3(Synphos)3(μ3‐OH)2]BF4 and [Rh3(Synphos)3(μ3‐Cl)2]BF4 and arene‐bridged dimer [Rh2(Synphos)2](BF4)2.