bluuebunny/crossref_metadata_2025_split huggingface dataset:
From a literature review of product configuration definitions to a reference framework
Authors: Oddsson Gudmundur , Ladeby Klaes R. 
Published: February 2014

AbstractThis paper presents a reference framework for the configuration process. The reference framework is established through an extensive review of existing literature, and as such consolidates an extensive theoretical base. The review of literature shows a broadening of the understanding of the configuration task. The definition of the configuration task is somewhat ambiguous because different research groups define configuration tasks differently. This paper proposes a reference framework for configuration that permits a more precise understanding of a configuration task, a definition of the basic concepts in product configuration, and a total configuration system view that describes how operators come together to perform the configuration task in the configuration process. We will define the product, the product model, the configuration task, and the configuration system, and put the whole thing into perspective with the theory of technical systems, where we describe the configuration process and the different abstraction level of configurations. We will also use our resulting framework to describe sales configuration, technical configuration, and reconfiguration. We do this to synthesize previous work, to clarify and make coherent definitions of relevant terms, to extent the definition of product configuration to include “softer” products like information and service, and finally, to give a comparative framework to analyze work done in the field of product configuration. The total configuration system, together with the definition of key concepts, comprises a strong reference framework when working with, developing, and analyzing configuration systems.
Adherence in a 1-year whole foods eating pattern intervention with healthy postmenopausal women
Authors: Peters Nancy Champe , Contento Isobel R , Kronenberg Fredi , Coleton Marci 
Published: February 2014

AbstractObjectiveTo determine the degree of dietary adherence or change in eating patterns, and demographic, psychosocial and study characteristics associated with adherence, in the Comparing Healthy Options in Cooking and Eating (CHOICE) Study.DesignRandomized controlled trial where women were randomized to one of three eating patterns: (i) Whole Foods, plant-based, macrobiotic-style (n 22); and Moderate Fat with (ii), and without (iii), 10 g of ground flaxseed added daily, which were combined (n 49).SettingA year-long intervention based on social cognitive theory, consisting of twenty-four class sessions involving hands-on cooking classes and behavioural sessions. Monthly 24 h food recalls were obtained and a psychosocial questionnaire was administered at baseline, 6 and 12 months.SubjectsHealthy, free-living, postmenopausal women.ResultsA non-adherence score measuring all food servings out-of-compliance with eating pattern recommendations was specifically designed for the present study. Non-adherence scores decreased significantly (P < 0·05) in both groups to about 65 % during the adoption phase (first 4 months) and remained so during the 8-month maintenance period. Class attendance of the Moderate Fat group showed a trend towards significance as a predictor of adherence (P = 0·063). None of the other predictors (e.g. demographic and psychosocial factors) in a longitudinal regression model were significant.ConclusionsPostmenopausal women were able to adopt and maintain significant changes in their eating patterns, including those on a demanding, near-vegetarian eating plan, suggesting that behavioural interventions with a healthy free-living population can be effective. The non-adherence score developed for the study provides an example of a means for evaluating eating pattern adherence to a dietary intervention.
A Mechanistic Model of Drug‐Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial
Authors: Howell BA , Siler SQ , Shoda LKM , Yang Y , Woodhead JL , Watkins PB 
Published: February 2014

Entolimod (CBLB502) is a Toll‐like receptor 5 agonist in development as a single‐dose countermeasure against total body irradiation. Efficacy can be assessed from animal studies, but the “Animal Rule” does not apply to safety assessment. Marked elevations of serum aminotransferases (exceeding 1,000 IU/l) were observed in some human subjects receiving Entolimod in a safety study, threatening its continued development. The percentage of total hepatocytes undergoing necrosis in these subjects was estimated using a mechanistic, multiscale, mathematical model (DILIsym). The simulations suggested that no subject in the safety study experienced more than a modest loss of hepatocytes (<5%), which was comparable to estimates from a study of healthy volunteers receiving treatment with heparins. The predicted hepatocyte loss with Entolimod was lower than that required to cause liver dysfunction or that is routinely excised from volunteers donating for autologous liver transplantation and did not likely represent a serious health risk.CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e98; doi:10.1038/psp.2013.74; published online 5 February 2014
Brownian Motion in a Speckle Light Field: Tunable Anomalous Diffusion and Selective Optical Manipulation
Authors: Volpe Giorgio , Volpe Giovanni , Gigan Sylvain 
Published: February 2014

AbstractThe motion of particles in random potentials occurs in several natural phenomena ranging from the mobility of organelles within a biological cell to the diffusion of stars within a galaxy. A Brownian particle moving in the random optical potential associated to aspeckle pattern, i.e., a complex interference pattern generated by the scattering of coherent light by a random medium, provides an ideal model system to study such phenomena. Here, we derive a theory for the motion of a Brownian particle in a speckle field and, in particular, we identify its universal characteristic timescale. Based on this theoretical insight, we show how speckle light fields can be used to control the anomalous diffusion of a Brownian particle and to perform some basic optical manipulation tasks such as guiding and sorting. Our results might broaden the perspectives of optical manipulation for real-life applications.
Controlling the shape of LiCoPO4 nanocrystals by supercritical fluid process for enhanced energy storage properties
Authors: Truong Quang Duc , Devaraju Murukanahally Kempaiah , Ganbe Yoshiyuki , Tomai Takaaki , Honma Itaru 
Published: February 2014

AbstractLithium-ion batteries offer promising opportunities for novel energy storage systems and future application in hybrid electric vehicles or electric vehicles. Cathode materials with high energy density are required for practical application. Herein, high-voltage LiCoPO4 cathode materials with different shapes and well-developed facets such as nanorods and nanoplates with exposed {010} facets have been synthesized by a one-pot supercritical fluid (SCF) processing. The effect of different amines and their roles on the morphology-control has been investigated in detail. It was found that amine having long alkyl chain such as hexamethylenediamine played important roles to manipulate the shape of the nanocrystals by selective adsorption on the specific {010} facets. More importantly, the nanorods and nanoplates showed better electrochemical performance than that of nanoparticles which was attributed to their unique crystallographic orientation with short Li ion diffusion path. The present study emphasizes the importance of crystallographic orientation in improving the electrochemical performance of the high voltage LiCoPO4 cathode materials for Li-ion batteries.
Experimental observation of ferrielectricity in multiferroic DyMn2O5
Authors: Zhao Z. Y. , Liu M. F. , Li X. , Lin L. , Yan Z. B. , Dong S. , Liu J. -M. 
Published: February 2014

AbstractOne of the major breakthroughs associated with multiferroicity in recent years is the discovery of ferroelectricity generated by specific magnetic structures in some magnetic insulating oxides such as rare-earth manganites RMnO3 and RMn2O5. An unresolved issue is the small electric polarization. Relatively large electric polarization and strong magnetoelectric coupling have been found in those manganites of double magnetic ions: magnetic rare-earth R ion and Mn ion, due to the strong R-Mn (4f-3d) interactions. DyMn2O5 is a representative example. We unveil in this work the ferrielectric nature of DyMn2O5, in which the two ferroelectric sublattices with opposite electric polarizations constitute the ferrielectric state. One sublattice has its polarization generated by the symmetric exchange striction from the Mn-Mn interactions, while the polarization of the other sublattice is attributed to the symmetric exchange striction from the Dy-Mn interactions. We present detailed measurements on the electric polarization as a function of temperature, magnetic field and measuring paths. The present experiments may be helpful for clarifying the puzzling issues on the multiferroicity in DyMn2O5 and other RMn2O5 multiferroics.
Autocatalytic Oxidization of Nanosilver and Its Application to Spectral Analysis
Authors: Wen Guiqing , Luo Yanghe , Liang Aihui , Jiang Zhiliang 
Published: February 2014

AbstractThe stable yellow nanosilver (AgNP) and blue nanosilver (AgNPB) sols were prepared by the NaBH4 procedure. The new nanocatalytic reaction of AgNP-NaCl-H2O2 was investigated by surface plasmon resonance (SPR) absorption, resonance Rayleigh scattering (RRS), surface-enhanced Raman scattering (SERS) and scanning electron microscope (SEM) techniques. The autocatalytic oxidization of Ag on AgNP surface by H2O2 was observed firstly and the AgNP/AgCl nanoparticles were characterized. The [Ag+] from AgNP is different to the Ag+ from AgNO3 that adsorb on the AgNP surface. An autocatalytic oxidization mechanism was proposed to explain experimental phenomena. The relationship between the SPR absorption peaks and the RRS peaks of AgNPB was studied and three characteristic RRS peaks called as out-of-plane quadrupole, out-of-plane dipole and in-plane dipole RRS peaks were observed firstly. Using AgNP as nanoprobe, a simple, sensitive and selective RRS method was developed for assay of H2O2 in the range of 2.0 × 10−8-8.0 × 10−5 mol/L.
Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8
Authors: Ahn G-One , Seita Jun , Hong Beom-Ju , Kim Young-Eun , Bok Seoyeon , Lee Chan-Ju , Kim Kwang Soon , Lee Jerry C. , Leeper Nicholas J. , Cooke John P. , Kim Hak Jae , Kim Il Han , Weissman Irving L. , Brown J. Martin 
Published: February 2014

SignificanceHere, we are reporting our findings that hypoxia-inducible factor 1 (HIF-1) activation in monocytes promotes neovascularization in matrigel and improves blood flow in hindlimb ischemia through production of vascular endothelial growth factor and S100A8. We found that HIF-1 regulates S100A8 expression specifically in monocytes isolated from our unique strain of transgenic mice targeting HIF pathways.
AMASS: a database for investigating protein structures
Authors: Mielke Clinton J. , Mandarino Lawrence J. , Dinu Valentin 
Published: February 2014

Abstract
Motivation: Modern techniques have produced many sequence annotation databases and protein structure portals, but these Web resources are rarely integrated in ways that permit straightforward exploration of protein functional residues and their co-localization.
Results: We have created the AMASS database, which maps 1D sequence annotation databases to 3D protein structures with an intuitive visualization interface. Our platform also provides an analysis service that screens mass spectrometry sequence data for post-translational modifications that reside in functionally relevant locations within protein structures. The system is built on the premise that functional residues such as active sites, cancer mutations and post-translational modifications within proteins may co-localize and share common functions.
Availability and implementation: AMASS database is implemented with Biopython and Apache as a freely available Web server at amass-db.org.
Contact: clinton.mielke@gmail.com
Linking spatial stock dynamics and economics: evaluation of indicators and fishery management for the travelling eastern king prawn (Melicertus plebejus)
Authors: O'Neill Michael F. , Leigh George M. , Wang You-Gan , Braccini J. Matías , Ives Matthew C. 
Published: February 2014

Abstract
Reduced economic circumstances have moved management goals towards higher profit, rather than maximum sustainable yields in several Australian fisheries. The eastern king prawn is one such fishery, for which we have developed new methodology for stock dynamics, calculation of model-based and data-based reference points and management strategy evaluation. The fishery is notable for the northward movement of prawns in eastern Australian waters, from the State jurisdiction of New South Wales to that of Queensland, as they grow to spawning size, so that vessels fishing in the northern deeper waters harvest more large prawns. Bioeconomic fishing data were standardized for calibrating a length-structured spatial operating model. Model simulations identified that reduced boat numbers and fishing effort could improve profitability while retaining viable fishing in each jurisdiction. Simulations also identified catch rate levels that were effective for monitoring in simple within-year effort-control rules. However, favourable performance of catch rate indicators was achieved only when a meaningful upper limit was placed on total allowed fishing effort. The methods and findings will allow improved measures for monitoring fisheries and inform decision makers on the uncertainty and assumptions affecting economic indicators.
Evaluation of determinants of Xiphopenaeus kroyeri (Heller, 1862) catch abundance along a Southwest Atlantic subtropical shelf
Authors: Kolling Juliana Almeida , Ávila-da-Silva Antônio Olinto 
Published: February 2014

Abstract
Generalized linear models were applied to identify factors affecting the capture rates (catch per unit effort, cpue) of Xiphopenaeus kroyeri and to estimate time-series data with standardized abundance indices. The adjusted models revealed that the most powerful vessels (with greater HP) were up to 3.5 times more efficient than vessels with less powerful engines. The seasonal variation of the resource changed from year to year, most likely due to variations in the recruitment season and the timing of temporary fishing bans. The variation of cpue was similar between the northern and southern sectors of the study area. In these, X. kroyeri abundances increased in the years 1996, 1997, 2001 and 2002, while in the central sector, the cpue fluctuated with a period duration of approximately two years. During the period, the relative abundance of the species displayed neither a decreasing nor an increasing trend, indicating that this has been harvested at stable levels. However, X. kroyeri stock was reduced by overfishing during the 1980s and exhibits variations in abundance that may occur in response to environmental fluctuations; thus, the harvesting of this species should be managed with extreme caution.
B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21
Authors: Hagn Magdalena , Blackwell Sue E. , Beyer Thamara , Ebel Verena , Fabricius Dorit , Lindner Stefanie , Stilgenbauer Stefan , Simmet Thomas , Tam Constantine , Neeson Paul , Trapani Joseph A. , Schrezenmeier Hubert , Weiner George J. , Jahrsdörfer Bernd 
Published: February 2014

AbstractCpG oligodeoxynucleotides (CpG) and IL-21 are two promising agents for the treatment of B-cell chronic lymphocytic leukemia (B-CLL). Recently, we reported that the combination of CpG and IL-21 (CpG/IL-21) can induce granzyme B (GrB)-dependent apoptosis in B-CLL cells. Here, we demonstrate that treatment of B-CLL cells with CpG and IL-21 results in the development of antigen-presenting cell (APC)-like cells with cytotoxic features. These properties eventually give rise to B-CLL cell apoptosis, independently of their cytogenetic phenotype, whereas normal B-cell survival is not negatively affected by CpG/IL-21. APC- and CTL-typical molecules found to be up-regulated in CpG/IL-21-stimulated B-CLL cells include GrB, perforin, T-bet, monokine-induced by IFN-γ and IFN-γ-inducible protein 10 (IP-10), as well as molecules important for cell adhesion, antigen cross-presentation and costimulation. Also induced are molecules involved in GrB induction, trafficking and processing, whereas the GrB inhibitor Serpin B9 [formerly proteinase inhibitor-9 (PI-9)] is down-modulated by CpG/IL-21. In conclusion, CpG/IL-21-stimulated B-CLL cells acquire features that are reminiscent of killer dendritic cells, and which result in enhanced immunogenicity, cytotoxicity and apoptosis. Our results provide novel insights into the aberrant immune state of B-CLL cells and may establish a basis for the development of an innovative cellular vaccination approach in B-CLL.
The Psychological Foundations of Human Rights
Authors: Kar Robin Bradley 
Published: February 2014

Abstract
This article examines the role of psychology in the historical foundation of human rights. It provides an account of the psychological capacities that humans use to identify and respond to rights and analyses the distinctive ways that humans reason about rights. It also discusses the basic psychology of rights and obligations and considers the place of the psychology of rights and obligations in a contemporary evolutionary framework. This article argues that while humans have an innate psychological capacity to identify and respond to rights, the more specific phenomenon of respect for human rights is at least in part a culturally emergent phenomenon.
The Foundations of Justice and Human Rights in Early Legal Texts and Thought
Authors: Lauren Paul Gordon 
Published: February 2014

Abstract
This article examines the contributions of early legal texts and thoughts to the development of the concept of justice and human rights. It analyses ideas about justice and human rights in ancient Near and Middle East, ancient China, ancient India, Classical Greece and Rome, the Medieval Period, the Renaissance, and the Enlightenment Period. It considers the relevant works of several ancient thinkers including Mencius, Plato and Cicero and suggests that they provided significant lessons and laid the essential foundations for developments that eventually would result in international human rights law.
General Principles and Constitutions as Sources of Human Rights Law
Authors: O’Boyle Michael , Lafferty Michelle 
Published: February 2014

Abstract
This article examines influence of general principles of law and constitutions in the formulation of human rights standards and in their interpretation and application by international courts, particularly the Universal Declaration of Human Rights (UDHR). It describes and compares the application and interpretation of human rights by the International Court of Justice (ICJ), the European and Inter-American Courts of Human Rights, and the Court of Justice of the European Union (CJEU). This article also highlights the fact that majority of human rights instruments and provisions subsequently adopted at the national and international levels have built upon the guarantees elaborated by the UDHR.
Diplomatic Protection as a Source of Human Rights Law
Authors: Vermeer-Künzli Annemarieke 
Published: February 2014

Abstract
This article examines the influence of the law of diplomatic protection on the development of international human rights law. It explains the legal rules concerning diplomatic protection and discusses its territorial and nationality dimensions. It argues that the law on diplomatic protection has played an important role in setting some benchmarks for the protection of individuals and that the most important element has not only been the international minimum standard itself but the acceptance that this standard prevailed over national law by the mid-1920s.
Social Justice, Rights, and Labour
Authors: Diller Janelle M. 
Published: February 2014

Abstract
This article examines the issues of social justice, social rights, and the international labour movement in relation to international human rights. It traces the history of the emergence of international labour law and describes the action and innovation of the International Labor Organization (ILO). It suggests that the ILO�s structural machinery and guiding principles served as the global reference point for setting and supervising standards on workers� rights, freedoms, and entitlements.
Subsidiarity
Authors: Neuman Gerald L. 
Published: February 2014

Abstract
This article examines the role of the principle of subsidiarity in international human rights law. It explains the concept and the procedural doctrines of subsidiarity and considers subsidiarity of international institutions as a structural fact and the substantive subsidiarity within the state. It contends that international protection of human rights is subsidiary to national protection and that subsidiarity plays important roles in international human rights law. This article also predicts the future expansion and evolution of the role of subsidiarity in international human rights law.
Sovereignty
Authors: van der Vyver Johan D. 
Published: February 2014

Abstract
This article examines the impact of the principle of state sovereignty on the enforcement of international human rights law. It contends that while state sovereignty may still be an obstacle to the implementation of human rights and fundamental freedoms within many municipal legal systems, governments that engage in serious violations of the internationally accepted human rights norms will inevitably bear the brunt of their unbecoming laws and practices. This article also argues that state sovereignty is thus no longer an absolute right and that its implementation has become subordinate to the values imbedded in the human rights doctrine.
Solidarity
Authors: Wolfrum Rüdiger 
Published: February 2014

Abstract
This article examines the role and influence of the principle of solidarity on international human rights law. It analyses the pronouncement of the United Nations on solidarity and the impact of solidarity on some international legal regimes concerned with peace, trade law and environmental law. This article argues that solidarity not only facilitated the internationalization of human rights concerns but also significantly influenced modern doctrines of reparations for human rights victims, the responsibility to protect and humanitarian assistance.
Democracy and the Rule of Law
Authors: Tomuschat Christian 
Published: February 2014

Abstract
This article examines the role of the rule of law and democracy in international human rights law. It discusses the legal nature and the formal recognition of the rule of law and democracy. It explains that that rule of law and democracy are elements that constitute essential pillars promoting real enjoyment of human rights but they are dependent on the general conditions prevailing within society. This article highlights the importance of the supervisory roles of international bodies in ensuring the effectiveness of the guarantees set forth in international instruments for the protection of human rights.
Core Rights and Obligations
Authors: Scheinin Martin 
Published: February 2014

Abstract
This article examines the three main approaches in the identification of the core rights and obligations in international human rights law. These include the consideration of some human rights as being superior or more fundamental than others, the notion that each human right encompasses an essential core and the definition of core obligations of the state in relation to the enjoyment of human rights. This article suggests that the best way to achieve a thorough understanding of the normative quality and content of human rights as legal rights is to combine these three approaches.