bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Blood Count Values Over Time in Young Children During the Dengue Virus Epidemic in the Dominican Republic From 2018 to 2020
Authors: Day Melissa E. , Puello Yonairy Collado , Mejía Sang Miguel E. , Diaz Brockmans Elvira J. , Díaz Soto María F. , Rivera Defilló Stephanie M. , Taveras Cruz Karla M. , Santiago Pérez Javier O. , Meña Rafael , Mota Cesár , Hostetter Margaret K. , Muglia Louis J. , del Rey Javier Gonzalez , Schlaudecker Elizabeth P. , Martin Lisa J. , Simpson Brittany N. , Prada Carlos E. 
Published: August 2024

Background: Dengue fever (DF) is a mosquito‐borne illness with substantial economic and societal impact. Understanding laboratory trends of hospitalized Dominican Republic (DR) pediatric patients could help develop screening procedures in low‐resourced settings. We sought to describe laboratory findings over time in DR children with DF and DF severity from 2018 to 2020.Methods: Clinical information was obtained prospectively from recruited children with DF. Complete blood count (CBC) laboratory measures were assessed across Days 1–10 of fever. Participants were classified as DF‐negative and DF‐positive and grouped by severity. We assessed associations of DF severity with demographics, clinical characteristics, and peripheral blood studies. Using linear mixed‐models, we assessed if hematologic values/trajectories differed by DF status/severity.Results: A total of 597 of 1101 with a DF clinical diagnosis were serologically evaluated, and 574 (471 DF‐positive) met inclusion criteria. In DF, platelet count and hemoglobin were higher on earlier days of fever (p < = 0.0017). Eighty had severe DF. Severe DF risk was associated with thrombocytopenia, intraillness anemia, and leukocytosis, differing by fever day (p < = 0.001).Conclusions: In a pediatric hospitalized DR cohort, we found marked anemia in late stages of severe DF, unlike the typically seen hemoconcentration. These findings, paired with clinical symptom changes over time, may help guide risk‐stratified screenings for resource‐limited settings.
Induced Pluripotent Stem Cells Facilitate the Development and Evaluation of Cancer Vaccines
Authors: Zhai Yuewen , Xu Xinyu , Fang Ji , He Fang , Li Siwen 
Published: August 2024

Abstract
Cancer vaccines are an approach to elicit amplified antigen-specific immune responses. Induced pluripotent stem cells (iPSC) have potential utility for the development of universal vaccines because of their intrinsic antigenic epitopes. Concurrently, iPSCs can undergo pluripotent differentiation and are thus a stable source of both antigen-presenting cells for producing immune cell-based vaccines and tumor organoids for facilitating the exploration and adaptive assessment of tumor vaccines. This review describes the specific contributions of iPSCs to vaccine development, summarizes their diverse developmental trajectories, and discusses the obstacles to their application along with potential solutions.
Repurposing NAMPT Inhibitors for Germinal Center B Cell–Like Diffuse Large B-Cell Lymphoma
Authors: Scuoppo Claudio , Cai Bowen , Ofori Kenneth , Scholze Hanna , Kumar Rahul , D’Alessandro Angelo , Basso Katia , Pasqualucci Laura , Dalla-Favera Riccardo 
Published: August 2024

Abstract
Diffuse large B-cell lymphoma (DLBCL) includes the activated B cell–like (ABC) and germinal center B cell–like (GCB) subtypes, which differ in cell of origin, genetics, and clinical response. By screening the subtype-specific activity of 211 drugs approved or in active clinical development for other diseases, we identified inhibitors of nicotinamide phosphoribosyl transferase (NAMPTi) as active in a subset of GCB-DLBCL in vitro and in vivo. We validated three chemically distinct NAMPTis for their on-target activity based on biochemical and genetic rescue approaches and found the ratio between NAMPT and PARP1 RNA levels was predictive of NAMPTi sensitivity across DLBCL subtypes. Notably, the NAMPT:PARP1 transcript ratio predicts higher antitumor activity in BCL2-translocated GCB-DLBCL. Accordingly, pharmacologic and genetic inhibition of BCL2 was potently synergistic with NAMPT blockade. These data support the inhibition of NAMPT as a therapeutically relevant strategy for BCL2-translocated DLBCLs.
Significance: Targeted therapies have emerged for the ABC subtype of DLBCL, but not for the GCB subtype, despite the evidence of a significant subset of high-risk cases. We identify a drug that specifically targets a subset of GCB-DLBCL and provide preclinical evidence for BCL2 translocations as biomarkers for their identification.
ANGPTL4 Suppresses Clear Cell Renal Cell Carcinoma via Inhibition of Lysosomal Acid Lipase
Authors: Jin Zeng , De Umasankar , Tithi Tanzia Islam , Kleberg Jeremy , Nataraj Akhila , Jolley Elena , Carelock Madison E. , Davies Brandon S. , Zhang Weizhou , Kolb Ryan 
Published: August 2024

Abstract

Renal cell carcinoma (RCC), the most common form of kidney cancer, is a heterogeneous disease with clear cell RCC (ccRCC) being the most prevalent and aggressive subtype. While most ccRCC tumors have elevated expression of angiopoietin-like4 (ANGPTL4), in our study we identified a significant subset of patients whose cancers show no increase in ANGPTL4 expression. These patients have a worse prognosis compared to the patients with high expression of ANGPTL4. These ANGPTL4-low cancers are characterized by the increased frequency of wild-type Von Hippel-Lindau(WT VHL), a gene that is commonly mutated in ccRCC, and an enrichment for genes associated with lipid metabolism. Using RCC tumor models with WT VHL, we demonstrate that ANGPTL4 behaves as a tumor suppressor. The loss of ANGPTL4 in ccRCC cell lines results in increased tumor growth and colony formation in a lysosomal acid lipase (LAL)-dependent manner, a phenotype rescued by the expression of N-terminus ANGPTL4. At the mechanistic level, the loss of ANGPTL4 increases LAL activity in ccRCC cells. These data suggest that ANGPTL4 enacts its tumor-suppressive effects in ccRCC by regulating LAL activity. Importantly, the identified patient cohort with low ANGPTL4 expression may exhibit increased reliance on lipid metabolism, which can be a point of target for future therapy.

Significance:
Our data indicate angiopoietin-like 4 (ANGPTL4) acts as a tumor suppressor in clear cell renal cell carcinoma via regulating lipid metabolism and identifies a cohort of patients with lower expression of ANGPTL4 that are correlated with shorter survival.
Human Visual Pathways for Action Recognition versus Deep Convolutional Neural Networks: Representation Correspondence in Late but Not Early Layers
Authors: Peng Yujia , Gong Xizi , Lu Hongjing , Fang Fang 
Published: August 2024

Abstract
Deep convolutional neural networks (DCNNs) have attained human-level performance for object categorization and exhibited representation alignment between network layers and brain regions. Does such representation alignment naturally extend to other visual tasks beyond recognizing objects in static images? In this study, we expanded the exploration to the recognition of human actions from videos and assessed the representation capabilities and alignment of two-stream DCNNs in comparison with brain regions situated along ventral and dorsal pathways. Using decoding analysis and representational similarity analysis, we show that DCNN models do not show hierarchical representation alignment to human brain across visual regions when processing action videos. Instead, later layers of DCNN models demonstrate greater representation similarities to the human visual cortex. These findings were revealed for two display formats: photorealistic avatars with full-body information and simplified stimuli in the point-light display. The discrepancies in representation alignment suggest fundamental differences in how DCNNs and the human brain represent dynamic visual information related to actions.
The serotonergic psychedelic N,N-dipropyltryptamine alters information-processing dynamics in in vitro cortical neural circuits
Authors: Varley Thomas F. , Havert Daniel , Fosque Leandro , Alipour Abolfazl , Weerawongphrom Naruepon , Naganobori Hiroki , O’Shea Lily , Pope Maria , Beggs John 
Published: August 2024

Abstract
Most of the recent work in psychedelic neuroscience has been done using noninvasive neuroimaging, with data recorded from the brains of adult volunteers under the influence of a variety of drugs. While these data provide holistic insights into the effects of psychedelics on whole-brain dynamics, the effects of psychedelics on the mesoscale dynamics of neuronal circuits remain much less explored. Here, we report the effects of the serotonergic psychedelic N,N-diproptyltryptamine (DPT) on information-processing dynamics in a sample of in vitro organotypic cultures of cortical tissue from postnatal rats. Three hours of spontaneous activity were recorded: an hour of predrug control, an hour of exposure to 10-μM DPT solution, and a final hour of washout, once again under control conditions. We found that DPT reversibly alters information dynamics in multiple ways: First, the DPT condition was associated with a higher entropy of spontaneous firing activity and reduced the amount of time information was stored in individual neurons. Second, DPT also reduced the reversibility of neural activity, increasing the entropy produced and suggesting a drive away from equilibrium. Third, DPT altered the structure of neuronal circuits, decreasing the overall information flow coming into each neuron, but increasing the number of weak connections, creating a dynamic that combines elements of integration and disintegration. Finally, DPT decreased the higher order statistical synergy present in sets of three neurons. Collectively, these results paint a complex picture of how psychedelics regulate information processing in mesoscale neuronal networks in cortical tissue. Implications for existing hypotheses of psychedelic action, such as the entropic brain hypothesis, are discussed.
Dynamic patterns of the disruptive and consolidating knowledge flows in Nobel-winning scientific breakthroughs
Authors: Yang Alex J. , Deng Sanhong 
Published: August 2024

Abstract
Scientific breakthroughs possess the transformative potential to reshape research trajectories and scientific paradigms. However, there is limited systematic evidence on how these breakthroughs influence the evolution of scientific knowledge. Building on the concepts of disruption and consolidation in science, we categorize forward-citing papers into two distinct categories: Disruptive Citing Papers (DCP) and Consolidating Citing Papers (CCP). Analyzing the dynamic patterns of DCP and CCP in Nobel Prize–winning papers, we find that in the early postpublication phase, scientific breakthroughs generate more consolidating citations than disruptive citations. Additionally, CCP in this early phase demonstrate higher scientific impact. However, in the long-term phase, scientific breakthroughs generate more disruptive citations, with DCP often involving larger and more diverse teams. Linguistic analysis also uncovers nuanced differences between CCP and DCP. Furthermore, the dynamic patterns of knowledge flow in scientific breakthroughs differ significantly from control groups. Collectively, our results reveal that scientific breakthroughs initially consolidate knowledge before disrupting it in later phases, offering profound insights into the mechanisms driving scientific progress.
In vitro nematicidal efficacy of brassica-derived isothiocyanates against the root lesion nematode, Pratylenchus penetrans
Authors: Chekanai Vongai , Neilson Roy , Roberts David , Edwards Simon , Back Matthew 
Published: August 2024

Summary
Brassica plants naturally produce glucosinolates as secondary metabolites hydrolysed to biocidal isothiocyanates (ITCs). As such, they have the potential for nematode management through a strategy known as biofumigation. Pratylenchus penetrans causes significant yield losses in many important crops. Understanding the relative impact of different ITCs on the motility and mortality of this nematode species could provide some insights into the selection of relevant brassica biofumigants. The effects of 3.125, 6.25, 12.5, 25, and 50 μg ml−1 of pure Allyl, 2-Phenylethyl and Benzyl ITCs on the motility and mortality of P. penetrans were evaluated in laboratory in vitro assays. Motility was assessed after incubating the nematodes in ITCs for 24, 48 and 72 h with distilled water as a negative control. Motile and non-motile nematodes were counted. After motility assessment at 72 h, nematodes were rinsed and incubated in water for 48 h, after which live and dead nematodes were counted. Nematodes were considered dead if they remained non-motile after probing with a picking needle. Nematode motility and mortality were significantly affected by the type of ITC, concentration and time of exposure. The number of non-motile nematodes increased with increasing concentration and time of exposure across all tested ITCs. The ED50 values (concentration required to cause 50% non-motility) of Allyl, 2-Phenylethyl and Benzyl were 37.4, 12.8 and 8.6 μg ml−1 after 24 h exposure. The ITC with potentially the greatest nematicidal effect was Benzyl (LD50 = 3.2 μg ml−1), followed by 2-Phenylethyl (LD50 = 5.2 μg ml−1), and Allyl (LD50 = 9.9 μg ml−1). The LD50 of all ITCs were not different from the ED50 after 72 h, meaning the effects of ITCs could be considered irreversible. This study suggests that brassica biofumigants that produce Benzyl, Allyl and 2-Phenylethyl ITCs are promising candidates for biofumigation of P. penetrans.
Film Programming in the ussr: A Case Study of Moscow Cinemas (1946–1955)
Authors: Tanis Kristina , Balykova Anastasia , Karnaukhov Ivan 
Published: August 2024

Abstract
This article presents a database on film programming in Moscow cinemas between 1946 and 1955. It outlines the place of this research at the intersection of new cinema history and academic debates on film distribution in the field of Soviet history. The article describes the data collection, the coding to present the data, and the structure of the database, which consists of the three datasets on Moscow film programming (1946–1955), Moscow cinemas (1946–1955), and the 1952 film calendar. Concluding remarks summarize the knowledge obtained from the database and introduce the Soviet case into the international context of digital data collections for historical cinema studies.
Students’ Perspectives of Competency-based Medical Education in Undergraduate Psychiatry Clinical Training: A Qualitative Evaluation
Authors: Sethuraman Bhuvaneshwari , Chari Uttara , Perugu Shalini , Salazar Luke Joshua , Sreedaran Priya 
Published: August 2024

Background: Undergraduate (UG) medical students are one of the stakeholders and ultimate beneficiaries of the competency-based medical education (CBME) curriculum introduced in 2019 by the National Medical Commission (NMC). There is a dearth of literature on student perspectives on CBME Psychiatry clinical posting in India. Methods: Second professional students who attended the psychiatry clinical posting were invited to participate in the qualitative study. They were asked to give perspectives about the training during clinical posting based on a semi-structured questionnaire. Results: Written feedback forms were obtained from 44 students. Data were analyzed using thematic analysis. Results showed the perceived impact of posting (change in knowledge, skills, and attitude), barriers to learning (student factors, patient factors, interaction factors, structural factors), and feedback on training during clinical posting (structural factors, practice over theory). Conclusion: UG students perceived improvement in their knowledge, attitude, and clinical skills during their posting in Psychiatry. They reported several barriers to learning at variouslevels. Their feedback to improve the posting focused on demonstrating skills using patients rather than theory classes.
A pilot cluster randomised controlled trial, of an IMPlicit learning approach versus standard care, on recovery of mobility following stroke (IMPS)
Authors: Johnson Louise , Burridge Jane , Ewings Sean , Demain Sara 
Published: August 2024

Objectives To evaluate the delivery of rehabilitation using implicit motor learning principles in an acute stroke setting. Design Pilot, assessor-blind, cluster randomised controlled trial with nested qualitative evaluation. Setting Eight inpatient stroke units, UK. Participants People within 14 days of stroke onset, presenting with lower limb hemiplegia. Interventions Participants at control clusters received usual care. Participants at intervention clusters received rehabilitation using an Implicit Learning Approach (ILA); primarily consisting of reduced frequency instructions/feedback, and promotion of an external focus of attention. Video recording was used to understand the ability of intervention site therapists to adhere to the implicit learning principles, and to compare differences between groups. Measures Ability to recruit and retain clusters/participants; suitability and acceptability of data collection processes; appropriateness of fidelity monitoring methods; and appropriateness of chosen outcome measures. Results Eight stroke units participated, with four assigned to each group (intervention/control). Fifty-one participants were enrolled (intervention group 21; control group 30). Mean time since stroke was 6 days (SD 3.42; 0–14); mean age was 73 years (SD 14, 25–94). Of those approached to take part, 72% agreed. We found clear differences between groups with respect to the frequency and type of instructional statement. The ILA was acceptable to both patients and therapists. Conclusion It is feasible to evaluate the application and effectiveness of motor learning principles within acute stroke rehabilitation, using a cluster randomised design. A larger study is required to evaluate the benefits of each approach; we provide a range of sample size estimates required for this.
The Dynamics of Ego-Resilience Trajectories: Exploring the Roles of Individual, Family, and School Factors Among Multicultural Early Adolescents in South Korea
Authors: Yoo Changmin 
Published: August 2024

This study aimed to identify the patterns of ego-resilience trajectories among multicultural early adolescents in South Korea. A total of 1635 participants (50.8% female students; mean ages 9.98–13.97 years) were analyzed, and five latent classes were identified: mid increasing, mid decreasing, low maintaining, mid maintaining, and high increasing. Individual, family, and school factors were examined to identify their associations with ego-resilience trajectory patterns. Results showed that being male, having high self-esteem, and experiencing high levels of acculturation were associated with higher ego-resilience. In addition, the absence of neglect and higher income were related to higher ego-resilience. Support from family, peers, and teachers was found to be positively associated with ego-resilience development. These results indicate that interventions to develop ego-resilience among multicultural early adolescents should consider the individual, family, and school factors associated with the different trajectory patterns of ego-resilience.
“A Retrospective Evaluation of the Impact of Prenatal Diagnosis of Facial Clefts. Does Prenatal Diagnosis Matter?”
Authors: Valenti Alyssa , Fan Weijia , Asadourian Paul , Modi Vikash , Imahiyerobo Thomas A. 
Published: August 2024

Background With the advent of improved prenatal detection, some patients with facial clefting are diagnosed prenatally while others are diagnosed postnatally. There is limited data regarding the utility of prenatal diagnosis and how this affects care of patients with facial clefts. Methods and Materials A retrospective chart review was performed. Children with incomplete demographic data and those with syndromic conditions were excluded. The data were analyzed via Fisher's exact tests and Kruskal-Wallis tests (p < 0.05). Results 106 patients met inclusion criteria. Facial clefting was diagnosed prenatally at different frequencies depending on type of facial cleft- patients with cleft palate alone were less likely to be identified prenatally (p < 0.0001). Patients diagnosed prenatally were seen by craniofacial specialists at an earlier age compared to those diagnosed after birth (0.27 months vs 0.7 months, p < 0.001). Similarly, those with prenatal diagnosis underwent surgery at a younger age compared to those who were diagnosed postnatally (median: 3.6 months vs 10.67 months, p < 0.001) and experienced shorter lag time (median: 3.4 months vs 8.4 months, p = 0.027) from consultation to surgery. Importantly, prenatal diagnosis resulted in pre-surgical therapy more often than in children diagnosed postnatally (86% vs 22.2%, p < 0.001). Conclusions Our data suggests that patients with prenatal diagnosis of facial clefts were more likely to undergo pre-surgical therapy, presented to a craniofacial specialist at an earlier age, underwent surgery at an earlier age, and experienced less lag time between initial visit and surgery. More study is warranted to improve protocols for prenatal diagnoses to improve surgical outcomes.
Mechanical Ankle Joint Axis Point on a Hip-to-Calcaneus Long Leg View Correlates Significantly With SPECT/CT Activation in Symptomatic Asymmetric Ankle Osteoarthritis
Authors: Spierenburg Willemijn , de Vries Astrid , van der Wel Hylke , Kraeima Joep , Dal Muhammed , van Raaij Tom 
Published: August 2024

Background: Asymmetric joint load is the main cause of development of ankle osteoarthritis (OA). Realignment surgery aims to transfer ankle joint load from the degenerative area toward the uninvolved area. Determination of the optimal shift is still challenging. When the degenerative area is correlated to the ankle joint mechanical axis establishing an optimal target angle for corrective surgery may become more feasible. The primary aim of our study was to investigate if the area of ankle joint activation on single-photon emission computed tomography and conventional computed tomography (SPECT/CT) imaging correlates with the mechanical ankle joint axis point (MAJAP). Methods: In this cross-sectional study, patients 18 years or older with symptomatic asymmetric ankle OA and a hip-to-calcaneus long leg view with SPECT/CT of the affected ankle were eligible for inclusion. Primary outcome was MAJAP divided into 3 alignment categories (medial shift, neutral, lateral shift). SPECT/CT activation was determined in 8 different areas of the ankle joint. A Spearman rho correlation coefficient was calculated to investigate the relationship between the alignment categories and SPECT/CT activation in the 8 areas. Results: Forty-nine patients (mean age 58.8 [SD 10.0] years) with 52 ankles with moderate to severe asymmetric OA were included. A significantly (Spearman rho −0.379 [ P = .006] and Spearman rho −0.279 [ P = .045]) higher proportion of ankles with radioisotope uptake in the anteromedial ankle joint areas (zones 1 and 5) was seen in the medial shift category. A significantly (Spearman rho .312 ( P = .025)) higher proportion of ankles with radioisotope uptake in the anterolateral ankle joint area (zone 8) was seen in the lateral shift category. Conclusion: We found in this patient group that the area of SPECT/CT uptake in asymmetric ankle OA was associated to MAJAP measured on hip-to-calcaneus weightbearing views, although the strength of the correlation is weak to moderate. Consequently, nonweightbearing metabolic SPECT/CT radiotracer uptake has the potential to help determine the area to unload in ankle joint-preserving alignment surgery.