bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crystal‐Facet Engineering of Ferric Giniite by Using Ionic‐Liquid Precursors and Their Enhanced Photocatalytic Performances under Visible‐Light Irradiation
Authors: Duan Xiaochuan , Li Di , Zhang Huili , Ma Jianmin , Zheng Wenjun 
Published: March 2013

AbstractIn the work presented here, well‐dispersed ferric giniite microcrystals with controlled sizes and shapes are solvothermally synthesized from ionic‐liquid precursors by using 1‐n‐butyl‐3‐methylimidazolium dihydrogenphosphate ([Bmim][H2PO4]) as phosphate source. The success of this synthesis relies on the concentration and composition of the ionic‐liquid precursors. By adjusting the molar ratios of Fe(NO3)3⋅9H2O to [Bmim][H2PO4] as well as the composition of ionic‐liquid precursors, we obtained uniform microstructures such as bipyramids exposing {111} facets, plates exposing {001} facets, hollow spheres, tetragonal hexadecahedron exposing {441} and {111} facets, and truncated bipyamids with carved {001} facets. The crystalline structure of the ferric giniite microcrystals is disclosed by various characterization techniques. It was revealed that [Bmim][H2PO4] played an important role in stabilizing the {111} facets of ferric giniite crystals, leading to the different morphologies in the presence of ionic‐liquid precursors with different compositions. Furthermore, since these ferric giniite crystals were characterized by different facets, they could serve as model Fenton‐like catalysts to uncover the correlation between the surface and the catalytic performance for the photodegradation of organic dyes under visible‐light irradiation. Our measurements indicate that the photocatalytic activity of as‐prepared Fenton‐like catalysts is highly dependent on the exposed facets, and the surface area has essentially no obvious effect on the photocatalytic degradation of organic dyes in the present study. It is highly expected that these findings are useful in understanding the photocatalytic activity of Fenton‐like catalysts with different morphologies, and suggest a promising new strategy for crystal‐facet engineering of photocatalysts for wastewater treatment based on heterogeneous Fenton‐like process.
ChemInform Abstract: A Three‐Dimensional Aromatic B6Li8 Complex as a High Capacity Hydrogen Storage Material.
Authors: Tai Truong Ba , Nguyen Minh Tho 
Published: March 2013

AbstractOn the basis of theoretical calculations (B3LYP/6‐311+G), the title complex is predicted to be aromatic and a promising hydrogen storage material with a gravimetric density of up to 24%.
ChemInform Abstract: SrCo2Sn8 and BaCo2Sn8: Tin‐Rich Stannides with Distorted SnSn6 Octahedra within Three‐Dimensional [Co2Sn8] Networks.
Authors: Schwickert Christian , Poettgen Rainer 
Published: March 2013

AbstractThe title compounds are prepared from the elements (Ta tubes, 1100 K, 48 h) and characterized by powder XRD and magnetic susceptibility measurements.
ChemInform Abstract: Intense Turquoise and Green Colors in Brownmillerite‐Type Oxides Based on Mn5+ in Ba2In2‐xMnxO5+x.
Authors: Jiang Peng , Li Jun , Ozarowski A. , Sleight Arthur W. , Subramanian M. A. 
Published: March 2013

AbstractBrownmillerite‐type oxides Ba2In2‐xMnxO5+x (x = 0.1—0.7) are prepared by solid state reaction of BaCO3, In2O3, and Mn2O3 in air (1.
ChemInform Abstract: Hydrothermal Syntheses and Low Temperature Magnetic Behaviors of ACo3(P2O7)2 (A: Ca, Sr, Ba, Pb).
Authors: Yang Tao , Lin Jianhua 
Published: March 2013

AbstractTransparent brick‐shaped single crystals of the title compounds are hydrothermally synthesized from an aqueous mixture of CoCl2, M(OAc)2 (M: Sr, Pb, Ba) or CaO, and H3PO4 (autoclave, 220 °C, 5 d, about 80% yields) and characterized by magnetic susceptibility measurements.
ChemInform Abstract: Structural Transformations and Disordering in Zirconolite (CaZrTi2O7) at High Pressure.
Authors: Salamat Ashkan , McMillan Paul F. , Firth Steven , Woodhead Katherine , Hector Andrew L. , Garbarino Gaston , Stennett Martin C. , Hyatt Neil C. 
Published: March 2013

AbstractThe mineral zirconolite (CaZrTi2O7) shows a series of high pressure phase transformations.
ChemInform Abstract: Facile Synthesis and Regeneration of Mg(BH4)2 by High Energy Reactive Ball Milling of MgB2.
Authors: Gupta Shalabh , Hlova Ihor Z. , Kobayashi Takeshi , Denys Roman V. , Chen Fu , Zavaliy Ihor Y. , Pruski Marek , Pecharsky Vitalij K. 
Published: March 2013

AbstractMgB2 is mechanochemically hydrogenated to Mg(BH4)2 by high energy reactive ball milling.
ChemInform Abstract: Syntheses, Characterization and Magnetic Properties of Two Novel Inorganic—Organic Tungstoferrites, [Fe4III(H2O)2 (B‐α‐FeIIIW9O34)2] 10‐.
Authors: Zhang Dongdi , Wang Chunzhang , Li Suzhi , Liu Jiangping , Ma Pengtao , Wang Jingping , Niu Jingyang 
Published: March 2013

AbstractThe new compounds (III) and (IV) crystallize in the triclinic space group P$\bar 1$ with Z = 2 (single crystal XRD).
ChemInform Abstract: Synthesis, Structure and Characterization of Two New Copper(I)—Thioarsenates(III) Constructed by the [AsS3]3‐ and CuSx Units.
Authors: Yao Hua‐Gang , Ji Min , Ji Shou‐Hua , An Yong‐Lin 
Published: March 2013

AbstractThe new compounds (IV) and (VII) are characterized by single crystal XRD and optical absorption spectroscopy.
ChemInform Abstract: Catalytic Enantioselective Addition of Terminal 1,3‐Diynes to N‐Sulfonyl Aldimines: Access to Chiral Diynylated Carbinamines.
Authors: Liu Tian‐Lin , Zhang Heng‐Xia , Zheng Yan , Yao Qingwei , Ma Jun‐An 
Published: March 2013

AbstractThe title reaction proceeds in the presence of binol‐type ligands (I) for a broad variety of N‐sulfonyl aldimines (II) and terminal 1,3‐diynes (III) and (V).
ChemInform Abstract: New Bifunctional Organocatalysts Based on (R,R)‐Cyclohexane‐1,2‐diamine for the Asymmetric Addition of Nucleophiles to Aldehydes.
Authors: Maleev V. I. , Gugkaeva Z. T. , Tsaloev A. T. , Moskalenko M. A. , Khrustalev V. N. 
Published: March 2013

AbstractNovel catalysts based on (R,R)‐cyclohexane‐1,2‐diamine derivatives are synthesized and applied to the addition of diethylzinc and trimethylsilyl cyanide to aldehydes.
ChemInform Abstract: Homogeneous Dihydroxylation of Olefins Catalyzed by OsO42‐ Immobilized on a Dendritic Backbone with a Tertiary Nitrogen at Its Core Position.
Authors: Fujita Ken‐ichi , Inoue Kensuke , Tsuchimoto Teruhisa , Yasuda Hiroyuki 
Published: March 2013

AbstractA novel bis(ammonium osmate) core dendrimer efficiently catalyzes the homogeneous dihydroxylation of olefins with a low level of osmium leaching.
ChemInform Abstract: A Mild, Room‐Temperature Protection of Ketones and Aldehydes as 1,3‐Dioxolanes under Basic Conditions.
Authors: Hassner Alfred , Bandi Chennakesava Reddy , Panchgalle Sharad 
Published: March 2013

AbstractN‐Hydroxybenzenesulfonamide (Pilloti′s acid) works as highly efficient reagent under optimized conditions.
ChemInform Abstract: The Furan Route to Tropolones: Probing the Antiproliferative Effects of β‐Thujaplicin Analogues.
Authors: Oblak E. Zachary , Bolstad Erin S. D. , Ononye Sophia N. , Priestley Nigel D. , Hadden M. Kyle , Wright Dennis L. 
Published: March 2013

AbstractThe synthesis of a series of 10β‐thujaplicin analogues from dibromoenone (I) is described.
ChemInform Abstract: Nickel(II)‐Dipyridylphosphine‐Catalyzed Enantioselective Hydrosilylation of Ketones in Air.
Authors: Wu Fei‐Fei , Zhou Ji‐Ning , Fang Qiang , Hu Yi‐Hu , Li Shijun , Zhang Xi‐Chang , Chan Albert S. C. , Wu Jing 
Published: March 2013

AbstractA protocol for the stereoselective hydrosilylation of a variety of electron‐deficient aryl alkyl ketones is presented.
ChemInform Abstract: Visible‐Light‐Mediated α‐Arylation of Enol Acetates Using Aryl Diazonium Salts.
Authors: Hering Thea , Hari Durga Prasad , Koenig Burkhard 
Published: March 2013

AbstractThis is a mild method for the α‐arylation of ketones catalyzed by photoinduced electron transfer.
ChemInform Abstract: Hypoiodous Acid Initiated Rearrangement of Tertiary Propargylic Alcohols to α‐Iodoenones.
Authors: Moran Wesley J. , Rodriguez Arantxa 
Published: March 2013

AbstractIn situ generated hypoiodous acid initiates the rearrangement of tertiary propargylic alcohols to α‐iodoenones under mild conditions and in good yields.
ChemInform Abstract: Synthesis and Antimicrobial Evaluation of New Monocyclic β‐Lactams.
Authors: Pagadala Ramakanth , Meshram Jyotsna S. , Chopde Himani N. , Jetti Venkateshwarlu , Chidurala Praveen , Kusampally Uppalaiah 
Published: March 2013

AbstractNovel β‐lactams (III) (10 examples) are prepared via Staudinger [2+2] cycloaddition reaction and screened for their antibacterial and antifungal activity.
ChemInform Abstract: Synthesis of Polycyclic Isoindoline Derivatives via Tandem Pd‐Catalyzed Coupling, Propargyl—Allenyl Isomerization, [4 + 2] Cycloaddition and Aromatization Reaction.
Authors: Zhu Shugao , Cao Jian , Wu Luling , Huang Xian 
Published: March 2013

AbstractA highly efficient, facile, and mild synthesis of the title compounds is developed from easily available starting materials.
ChemInform Abstract: Reactions of Ketene Aminals with N‐Arylmaleimides and Dimethyl Acetylenedicarboxylate, a Direct Pathway to Derivatives of Pyrrolo[1,2‐a]imidazole and Imidazolo[1,2‐a]pyridine.
Authors: Orlov V. D. , Kharchenko Yu. V. , Gella I. M. , Omel'chenko I. V. , Shishkin O. V. 
Published: March 2013

AbstractIn some cases the reaction stops upon the addition of the imide or dimethyl acetylenedicarboxylate at the nitrogen of the imidazoline system.
ChemInform Abstract: A Simple and Convenient Synthesis of 4‐Ylidene‐5(4H)oxazolone Derivatives: Oxazolone Ring Transformation Leading to Other Heterocyclic Structures.
Authors: Abdel‐Motaleb Ramadan M. , Bakeer Hadeer M. , Tamam Gammal H. , Arafa Wael A. A. 
Published: March 2013

AbstractThe title compounds (III) are obtained from arylidene‐malononitriles under solvent‐free conditions.
ChemInform Abstract: Efficient One‐Pot Syntheses of Dibenzo[a,i]xanthene‐diones and Evaluation of Their Antioxidant Activity.
Authors: Khurana Jitender M. , Chaudhary Ankita , Lumb Anshika , Nand Bhaskara 
Published: March 2013

AbstractFacile, operationally simple, and high yielding procedures for the synthesis of dibenzo[a,i]xanthene‐diones are described.
ChemInform Abstract: Completely OH‐Selective FeCl3‐Catalyzed Prins Cyclization: Highly Stereoselective Synthesis of 4‐OH‐Tetrahydropyrans.
Authors: Zheng Ke , Liu Xiaohua , Qin Song , Xie Mingsheng , Lin Lili , Hu Changwei , Feng Xiaoming 
Published: March 2013

AbstractThis complete OH‐selective sequential ene/Prins cyclization towards 4‐hydroxy‐tetrahydropyrans is characterized by high enantioselectivity, broad substrate scope, facile procedure and mild reaction conditions.
ChemInform Abstract: Efficient and Mild One‐Pot Three‐Component Reaction to Synthesize Pyrano[3,2‐b]pyran Derivatives in Ionic Liquid.
Authors: Li Yuling , Zhao Bo , Du Baixing , Jiang Qiushi , Wang Xiangshan , Cao Changsheng 
Published: March 2013

AbstractA simple protocol employing triethylamine as the base in ionic liquid allows the synthesis of pyranopyrans under mild conditions.
ChemInform Abstract: FeCl3‐Catalyzed Cyclization of α‐Sulfonamido‐Allenes with Aldehydes — The Substituent Effect.
Authors: Cheng Jiajia , Tang Xinjun , Yu Yihua , Ma Shengming 
Published: March 2013

AbstractThe FeCl3‐mediated aza‐Prins‐cyclization reaction of α‐sulfonamido‐allenes (I) and (VI) with aldehydes affords selectively tetrahydropyridine (III) or dihydropyrrole derivatives (VIII), respectively.
ChemInform Abstract: A Convenient Approach for the Synthesis of 2,6‐Diformyl‐ and 2,6‐Diacetylpyridines.
Authors: Ivchenko Pavel V. , Nifant'ev Ilya E. , Buslov Ivan V. 
Published: March 2013

AbstractPyridine dicarboxamides (I) are suitable substrates for the synthesis of diacetyl‐ and diformylpyridines via reduction with methylmagnesium chloride or reduction with lithium aluminum hydride, respectively.
ChemInform Abstract: Cu(II)‐Promoted Three‐Component Coupling Sequence for the Efficient Synthesis of Substituted Quinolines.
Authors: Xiao Fuhong , Chen Wen , Liao Yunfeng , Deng Guo‐Jun 
Published: March 2013

AbstractThe title reaction tolerates a wide range of functional groups and affords 2‐arylquinolines in good yields under mild conditions.
ChemInform Abstract: An Alternative One‐Pot Gold‐Catalyzed Approach to the Assembly of 11H‐Indolo[3,2‐c]quinolines.
Authors: Abbiati Giorgio , Arcadi Antonio , Chiarini Marco , Marinelli Fabio , Pietropaolo Emanuela , Rossi Elisabetta 
Published: March 2013

AbstractTitle compounds are obtained mostly in high yields in the presence of the stable gold catalyst GAB avoiding a silver co‐catalyst.
ChemInform Abstract: Palladium‐Catalyzed Sonogashira‐Coupling Conjoined C—H Activation: A Regioselective Tandem Strategy to Access Indolo‐ and Pyrrolo[1,2‐a]quinolines.
Authors: Shukla Satya Prakash , Tiwari Rakesh K. , Verma Akhilesh K. 
Published: March 2013

AbstractA feasible and efficient one‐pot approach for the synthesis of the title compounds by sequential C—C bond formation is described.
ChemInform Abstract: Synthesis and Reactivity of 2‐Chloro‐3‐formylpyrido[2,1‐a]isoquinoline Derivatives (III). A Novel Route to Pyrazolo[3′,4′:4,5]pyrido[2,1‐a]isoquinoline and Isoquinolino[2,1‐g][1,6]naphthyridines.
Authors: Hassaneen Hamdi M. , Wardkhan Wagnat W. , Mohammed Yasmin Sh. 
Published: March 2013

AbstractPyrazolo[3′,4′:4,5]pyrido[2,1‐a]isoquinolines [(IV) and (VII)] and isoquinolino[2,1‐g][1,6]naphthyridines [(XII), (XVI), and (XIX)] are synthesized starting from 2‐chloro‐3‐formylpyrido[2,1‐a]isoquinoline derivative (III).
ChemInform Abstract: Organoiodine(III) Mediated Synthesis of Novel Symmetrical Bis([1,2,4]triazolo)[3,4‐a:4′,3′‐c]phthalazines as Antibacterial and Antifungal Agents.
Authors: Prakash Om , Aneja Deepak K. , Hussain Khalid , Kumar Ravi , Arora Sanjiv , Sharma Chetan , Aneja Kamal R. 
Published: March 2013

AbstractThe title compounds are conveniently synthesized by oxidative cyclization of phthalazines (III) promoted by iodobenzene diacetate under mild reaction conditions.
ChemInform Abstract: Synthesis, Structure, and Photoluminescence of 5‐Phenyl‐2‐pyridyl‐5,6‐dihydro[1,2,4]triazolo[1,5‐c]quinazolines.
Authors: Gusev A. N. , Shul'gin V. F. , Topilova Z. M. , Meshkova S. B. 
Published: March 2013

AbstractTitle compounds (III) represent a new class of substances luminescing in solid state as well as in solution.
ChemInform Abstract: Efficient Synthesis of Dihydropyrido[4,3‐d]pyrimidines by Microwave‐Promoted Three‐Component aza‐Diels—Alder Reaction.
Authors: Sarmah Manas M. , Sarma Rupam , Prajapati Dipak , Hu Wenhao 
Published: March 2013

AbstractA facile synthesis of the title compounds is achieved by microwave promoted three‐component aza‐Diels—Alder reaction of uracil derivative (I), aldehydes, and amines.
ChemInform Abstract: Thieno[2,3‐d]pyrimidines in the Synthesis of New Fused Heterocyclic Compounds of Prospective Antitumor and Antioxidant Agents. Part 2.
Authors: Aly Ashraf A. , Ramadan Mohamed , Mohamed Ashraf M. , Ishak Esam A. 
Published: March 2013

AbstractA variety of new fused thienopyrimidine derivatives are synthesized from thienopyrimidinethione (I) or ‐hydrazine (IX) and evaluated for their cytotoxicity and antioxidant activity.
ChemInform Abstract: YbCl3‐Catalyzed One‐Pot Synthesis of Dihydropyrazines, Piperazines, and Pyrazines.
Authors: Fan Liyan , Chen Wen , Qian Changtao 
Published: March 2013

AbstractThe YbCl3‐catalyzed reaction of α‐hydroxyketones with diamines gives dihydropyrazines.
ChemInform Abstract: Synthesis, DNA‐PK Inhibitory, anti‐Platelet Activity Studies of 2‐(N‐Substituted‐3‐aminopyridine)‐substituted‐1,3‐benzoxazines and DNA‐PK and PI3K Inhibition, Homology Modelling Studies of 2‐Morpholino‐(7,8‐di and 8‐substituted)‐1,3‐benzoxazines.
Authors: Ihmaid Saleh K. , Al‐Rawi Jasim M. A. , Bradley Christopher J. , Angove Michael J. , Robertson Murray N. 
Published: March 2013

AbstractA small library of novel 1,3‐benzoxazine derivatives is prepared and the DNA‐PK, PI3K, and platelet inhibitory activity of these substances is evaluated.
ChemInform Abstract: Synthesis and Antimicrobial Activity of 4‐(10H‐Phenothiazin‐2‐yl)‐pyrimidin‐2(1H)‐one/thione Derivatives.
Authors: Bansode Tanaji N. , Meshram Gangadhar A. 
Published: March 2013

AbstractReaction of urea or thiourea derivatives with chalcones (III), obtained by a Claisen—Schmidt reaction, provides access to new title pyrimidine derivatives (V) (16 examples).
ChemInform Abstract: Synthesis of [1,2,4]Triazolo[4,3‐b]‐s‐tetrazines with Incorporated Furazan Ring.
Authors: Sheremetev A. B. , Palysaeva N. V. , Suponitskii K. Yu. , Struchkova M. I. 
Published: March 2013

AbstractFurazancarboxylic hydrazines (II) can serve as nucleophiles to substitute one pyrazole fragment in bis‐pyrazolyl‐tetrazines (I).
ChemInform Abstract: Synthesis, Characterization, Biological Evaluation and QSAR Studies of 11‐p‐Substituted Phenyl‐12‐phenyl‐11a,12‐dihydro‐11H‐indeno[2,1‐c][1,5]benzothiazepines as Potential Antimicrobial Agents.
Authors: Mor Satbir , Pahal Preeti , Narasimhan Balasubramanian 
Published: March 2013

AbstractThe condensation reaction of (E)‐benzylideneindanones (I) with o‐aminobenzenethiols (II) proceeds diastereoselectively to furnish novel title benzothiazepine derivatives (III) (16 examples) as single diastereoisomers.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric 1,4‐Addition of Diarylphosphines to Nitroalkenes for the Synthesis of Chiral P,N‐Compounds.
Authors: Feng Jian‐Jun , Huang Miao , Lin Zi‐Qi , Duan Wei‐Liang 
Published: March 2013

AbstractThe highly stereoselective title reaction catalyzed under mild conditions provides an alternative method for the synthesis of chiral P,N compounds, e.g. the precursor (X) for organocatalysts.
ChemInform Abstract: Synthesis of the Novel β‐Aminophosphoryl Compounds and Their Acid‐Base Properties and Membrane‐Transport Abilities Towards Carboxylic Acids.
Authors: Cherkasov R. A. , Garifzyanov A. R. , Kurnosova N. V. , Matveeva E. V. , Odinets I. L. 
Published: March 2013

AbstractThe acid‐base properties and membrane‐transport abilities of newly synthesized β‐aminophosphoryl compounds (III) and (IV) towards carboxylic acids are studied.
ChemInform Abstract: Synthesis, Spectroscopic, and Dyeing Properties of New Azo and Bisazo Dyes Derived from 5‐Pyrazolones.
Authors: Bagdatli Emine , Ocal Nuket 
Published: March 2013

AbstractNovel azo and bisazo dyes such as (I)—(IV) are synthesized and tested for their dyeing and fastness properties.
ChemInform Abstract: Plantagiolides I and J, Two New Withanolide Glucosides from Tacca plantaginea with Nuclear Factor‐ϰB Inhibitory and Peroxisome Proliferator‐Activated Receptor Transactivational Activities.
Authors: Kim Young Ho , et al. et al. 
Published: March 2013

AbstractNew plantagiolides I (I) and J (II) are isolated together with six known compounds.
ChemInform Abstract: A New Cyclic Tetrapeptide from the Jellyfish‐Derived Fungus Phoma sp.
Authors: Kim Eun La , Li Jian Lin , Xiao Bin , Hong Jongki , Yoo Eun Sook , Yoon Won Duk , Jung Jee H. 
Published: March 2013

AbstractNew tentoxin B (I) is isolated together with two known congeners, dihydrotentoxin and tentoxin.
ChemInform Abstract: Flavonoid Glycosides from the Leaves of Allium victorialis var. Platyphyllum and Their Antineuroinflammatory Effects.
Authors: Woo Kyeong Wan , Moon Eunjung , Park So Young , Kim Sun Yeou , Lee Kang Ro 
Published: March 2013

Abstract[isolation, structure determination and antineuroinflammatory activities of new Stavonoid glycosides, i.
ChemInform Abstract: Synthesis and Biological Evaluation of a Novel Acronycine/Duocarmycin Hybrid Natural Product.
Authors: Tietze Lutz F. , Heins Arne , Reiner Johannes R. , Duefert Svenia‐C. , Schuberth Ingrid 
Published: March 2013

AbstractNovel acronycine/duocarmycin hybrid compound (I) is synthesized that reveals a slightly higher cytotoxicity than acronycine.
ChemInform Abstract: Synthesis and Antimicrobial Activity of New Thiazole Derivatives and Their Glucoside and Acyclic Nucleoside Analogues.
Authors: Ali Omar M. , El‐Sayed Wael A. , El‐Sayed Heba A. , Abdel‐Rahman Adel A.‐H. 
Published: March 2013

AbstractThiazole derivatives, their N‐substituted acyclic nucleoside analogues and substituted glucosides are synthesized and screened for their antimicrobial activities against C.
ChemInform Abstract: Compounds from the Heartwood of Caesalpinia sappan and Their Antiinflammatory Activity
Authors: Min Byung Sun , Cuong To Dao , Hung Tran Manh , Min Bo Kyung , Shin Beom Soo , Woo Mi Hee 
Published: March 2013

Abstractisolation, structural elucidation and antiinflammatory activity of two new phenolics, caesalpiniaphenol E (I) and caesalpiniaphenol F (II), along with eleven known compounds
Red Blood Cell Distribution Width Is a Predictor of Readmission in Cardiac Patients
Authors: Ephrem Georges 
Published: March 2013

AbstractBackgroundThree‐quarters of rehospitalizations ($44 billion yearly estimated cost) may be avoidable. A screening tool for the detection of potential readmission may facilitate more efficient case management.HypothesisAn elevated red blood cell distribution width (RDW) is an independent predictor of hospital readmission in patients with unstable angina (UA) or non–ST‐elevation myocardial infarction (NSTEMI).MethodsThe study is a retrospective observational cohort analysis of adults admitted in 2007 with UA or NSTEMI. Data were gathered by review of inpatient medical records. The rate of 30‐day nonelective readmission and time to nonelective readmission were recorded until November 1, 2011, and compared by RDW group using the 95th percentile (16.3%) as a cutoff.ResultsThe median follow‐up time of the 503 subjects (average age, 65 ± 13 years; 56% male) was 3.8 years (interquartile range: 0.3–4.3 years). Those readmitted within 30 days were older, had more comorbidities and higher RDW and creatinine levels, and were more likely to have had an intervention. At 3.8 years of follow‐up, subjects with high RDW (>16.3%) were more likely to be readmitted compared to those with normal RDW (≤16.3%) (72.28% vs 59.95%, P = 0.003). In multivariable analyses, high RDW was a statistically significant predictor of readmission in general (hazard ratio: 1.35 (95% confidence interval [CI]:1.02‐1.79), P = 0.033) but not of 30‐day rehospitalization (odds ratio: 1.34 (95% CI: 0.78‐2.31), P = 0.292). Its area under the receiver operating characteristic curve was 0.54 (sensitivity 23% and specificity 85%).ConclusionsAn elevated RDW is an independent predictor of hospital readmission in patients with UA or NSTEMI.
Potent Agonists of a Hematopoietic Stem Cell Cytokine Receptor, c‐Mpl
Authors: Tarasova Anna , Haylock David N. , Meagher Laurence , Be Cheang Ly , White Jacinta , Nilsson Susan K. , Andrade Jessica , Cartledge Kellie , Winkler David A. 
Published: March 2013

AbstractSeveral growth factors feature prominently in the control of hematopoiesis. Thrombopoietin, a class I hematopoietic cytokine, plays critical roles in regulating hematopoietic stem cell numbers and also stimulates the production and differentiation of megakaryocytes, the bone marrow cells that ultimately produce platelets. Thrombopoietin interacts with the c‐Mpl cell‐surface receptor. Recently, several peptide and small‐molecule agonists and antagonists of c‐Mpl have been reported. We conducted a bioinformatics and molecular modeling study aimed at understanding the agonist activities of peptides that bind to c‐Mpl, and developed new potent peptide agonists with low nanomolar activity. These agonists also show very high activity in human CD34+ primary cell cultures, and doubled the mean blood platelet counts when injected into mice.