bluuebunny/crossref_metadata_2025_split huggingface dataset:
GFDL’s ESM2 Global Coupled Climate–Carbon Earth System Models. Part II: Carbon System Formulation and Baseline Simulation Characteristics*
Authors: Dunne John P. , John Jasmin G. , Shevliakova Elena , Stouffer Ronald J. , Krasting John P. , Malyshev Sergey L. , Milly P. C. D. , Sentman Lori T. , Adcroft Alistair J. , Cooke William , Dunne Krista A. , Griffies Stephen M. , Hallberg Robert W. , Harrison Matthew J. , Levy Hiram , Wittenberg Andrew T. , Phillips Peter J. , Zadeh Niki 
Published: October 2012

Abstract
The authors describe carbon system formulation and simulation characteristics of two new global coupled carbon–climate Earth System Models (ESM), ESM2M and ESM2G. These models demonstrate good climate fidelity as described in part I of this study while incorporating explicit and consistent carbon dynamics. The two models differ almost exclusively in the physical ocean component; ESM2M uses the Modular Ocean Model version 4.1 with vertical pressure layers, whereas ESM2G uses generalized ocean layer dynamics with a bulk mixed layer and interior isopycnal layers. On land, both ESMs include a revised land model to simulate competitive vegetation distributions and functioning, including carbon cycling among vegetation, soil, and atmosphere. In the ocean, both models include new biogeochemical algorithms including phytoplankton functional group dynamics with flexible stoichiometry. Preindustrial simulations are spun up to give stable, realistic carbon cycle means and variability. Significant differences in simulation characteristics of these two models are described. Because of differences in oceanic ventilation rates, ESM2M has a stronger biological carbon pump but weaker northward implied atmospheric CO2 transport than ESM2G. The major advantages of ESM2G over ESM2M are improved representation of surface chlorophyll in the Atlantic and Indian Oceans and thermocline nutrients and oxygen in the North Pacific. Improved tree mortality parameters in ESM2G produced more realistic carbon accumulation in vegetation pools. The major advantages of ESM2M over ESM2G are reduced nutrient and oxygen biases in the southern and tropical oceans.
Evaluation of telephone health coaching of German health insurants with chronic conditions
Authors: Härter Martin , Dwinger Sarah , Seebauer Laura , Simon Daniela , Herbarth Lutz , Siegmund-Schultze Elisabeth , Temmert Daniel , Bermejo Isaac , Dirmaier Jörg 
Published: October 2012

Objective: This study aimed to investigate how patients with chronic conditions evaluate telephone health coaching provided by their health insurance company. Methods: A retrospective survey was conducted among coaching participants ( n=834). Outcomes included the general evaluation of the coaching, the evaluation of process and effects and the impact on patient-physician communication. Results: Participants’ average age was 66.2 years and the majority were women (58.3%). The majority (78.3%) of the insured persons were satisfied with the coaching and 82.3% would recommend it to others. More than half of the participants (53.3%) had learned about new options to influence their health condition. Sub-group differences in the evaluation of the health coaching were found for age, gender and medical condition. Conclusion: Health coaching might be useful in supporting patients with chronic conditions. While the results indicate a general positive appraisal, a possibility for improvement could be a stronger focus on the individual situation and the imparting of specific skills. Target groups might be selected in a specified manner for the coaching, as older participants in need of specific care seem to benefit less from the approach. Longitudinal and controlled studies are needed to investigate clinical effects of health coaching.
Superabsorbent hydrogels prepared from waste polystyrene and linear low-density polyethylene
Authors: Ismail Hanafi , Irani Maryam , Ahmad Zulkifli 
Published: October 2012

Superabsorbent hydrogels, polystyrene-graft-polyacrylic acid (PAA; PS- g-PAA), linear low-density polyethylene (LLDPE)-graft-PAA (LLDPE- g-PAA), and hydrogel composites, PS- g-PAA/bentonite (BT), were synthesized through emulsion polymerization using acrylic acid as a monomer, benzoyl peroxide as an oil-soluble initiator, and ammonium persulfate and sodium sulfite as a redox initiator in the presence of N, N-methylenebisacrylamide as a cross-linking agent. The superabsorbents were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The maximum water absorbencies for PS- g-PAA and PS- g-PAA/BT were 780 and 900 g g−1 in distilled water, respectively, while the water absorbency of LLDPE- g-PAA superabsorbent was 450 g g−1 in distilled water.
Clinical Consensus Statement
Authors: Setzen Gavin , Ferguson Berrylin J. , Han Joseph K. , Rhee John S. , Cornelius Rebecca S. , Froum Stuart J. , Gillman Grant S. , Houser Steven M. , Krakovitz Paul R. , Monfared Ashkan , Palmer James N. , Rosbe Kristina W. , Setzen Michael , Patel Milesh M. 
Published: October 2012

ObjectiveTo develop a consensus statement on the appropriate use of computed tomography (CT) for paranasal sinus disease.Subjects and MethodsA modified Delphi method was used to refine expert opinion and reach consensus by the panel.ResultsAfter 3 full Delphi rounds, 33 items reached consensus and 16 statements were dropped because of not reaching consensus or redundancy. The statements that reached consensus were grouped into 4 categories: pediatric sinusitis, medical management, surgical planning, and complication of sinusitis or sinonasal tumor. The panel unanimously agreed with 13 of the 33 statements. In addition, at least 75% of the panel strongly agreed with 14 of 33 statements across all of the categories.ConclusionsFor children, careful consideration should be taken when performing CT imaging but is needed in the setting of treatment failures and complications, either of the pathological process itself or as a result of iatrogenic (surgical) complications. For adults, imaging is necessary in surgical planning, for treatment of medical and surgical complications, and in all aspects of the complete management of patients with sinonasal and skull base pathology.
Headache in patients with pituitary adenoma: Clinical and paraclinical findings
Authors: Schankin Christoph J , Reifferscheid Anna K , Krumbholz Markus , Linn Jennifer , Rachinger Walter , Langer Sigrid , Sostak Petra , Arzberger Thomas , Kretzschmar Hans , Straube Andreas 
Published: October 2012

Aim: The aim of this article is to generate hypotheses for the mechanism of pituitary adenoma headache. Patients and methods: Fifty-eight patients with pituitary adenoma were prospectively analysed for prevalence and manifestation of tumour headache. Intrapersonal and neoplasm-associated risk factors were assessed. Results: Twenty-four patients (41%) had tumour-attributed headache, seven had migraine-like, 11 tension-type headache-like headache, and three both. Cluster headache-like headache was found once, and two headaches remained unclassified. Tumour-attributed headache was associated with a positive history of headache ( p = 0.03; OR 3.4), nicotine abuse ( p < 0.01; OR 4.7), intake of acute headache medication ( p = 0.04; OR 3.3), and a higher tumour proliferation indicated by a Ki67-labelling index (LI) >3% ( p = 0.02; OR 11.0). For patients with migraine-like tumour-attributed headache, risk factors were younger age ( p = 0.02), nicotine abuse ( p < 0.01; OR 10.9), acute headache treatment ( p < 0.01; OR 9.0), and Ki67-LI >3% ( p = 0.03; OR 14.1). For tension-type headache-like headache, the main risk factor was a positive history of tension-type headache ( p = 0.045; OR 5.6). Conclusion: Headache predisposition and local tumour effects might be important for the pathophysiology of pituitary adenoma headache and tumour headache in general.
Metabolomic analysis of rat plasma following chronic low-dose exposure to dichlorvos
Authors: Yang J , Wang H , Xu W , Hao D , Du L , Zhao X , Sun C 
Published: October 2012

This study aims to assess the metabolomic profile and related histopathological outcomes of rat plasma after chronic low-dose exposure to dichlorvos (DDVP). A total of 120 male Wistar rats were treated with 0, 2.4, 7.2, and 21.6 mg/kg of body weight/day DDVP continuously for 24 weeks by drinking water. Rat plasma samples were collected at different time-points to measure the metabolomic profiles by ultra-performance liquid chromatography–mass spectrometry (UPLC-MS). Liver tissue analysis was performed to correlate histopathological outcome status to plasma metabolomics. Significant changes in some of the metabolites were found in all the treated groups compared with the control group. LysoPC (15:0/0:0), LysoPC (16:0/0:0), LysoPC (17:0/0:0), LysoPC (0:0/18:0), sphingosine, sphinganine, C16 sphinganine, C17 sphinganine, and arachidonic acid were decreased in the treated groups. LysoPE (16:0/0:0) was increased after dosing with DDVP. Histopathological test outcomes coincided with the plasma metabolomic-profile analysis results obtained by UPLC-MS. The livers were damaged following chronic exposure to DDVP. Abnormal changes in some lipids in the plasma, such as LysoPC (0:0/18:0), were closely related to liver dysfunction. Therefore, metabolomic analysis provides the unique advantages of unveiling the mechanisms of DDVP.
Exposure of family members to antineoplastic drugs via excreta of treated cancer patients
Authors: Yuki Michiko , Sekine Satoko , Takase Kanae , Ishida Takashi , Sessink Paul JM 
Published: October 2012

Purposes: (a) To measure the urinary excretion of antineoplastic drugs of three patients during 48 h after the administration of cyclophosphamide (two patients) and 5-fluorouracil (one patient). (b) To evaluate environmental contamination with antineoplastic drugs via excreta of patients in the home setting. (c) To evaluate exposure of family members to antineoplastic drugs by measuring the drugs in their urine during the 48 h after completion of the chemotherapy by the patients. Methods: Two patients were administered cyclophosphamide by i.v. bolus injection. One patient was administered 5-fluorouracil by i.v. bolus injection and thereafter immediately administered the same drug by continuous infusion for 46 h. Urine samples from the patients administered cyclophosphamide and their family members, and wipe samples from their home environment, were analysed for the unchanged form of cyclophosphamide. For 5-fluorouracil, the urine samples from the patient and the family member were analysed for the 5-fluorouracil metabolite α-fluoro-β-alanine. Wipe samples were analysed for 5-fluorouracil. Drugs were detected and quantified with gas chromatography in tandem with mass spectroscopy-mass spectroscopy or by high-performance liquid chromatography with ultraviolet-light detection. Results: A total of 35 and 16 urine samples were collected from the three patients and their family members, respectively. The drugs were detected in all samples. Cyclophosphamide was detected at levels of 0.03–7.34 ng/cm2 in 8 of the 12 wipe samples obtained from the homes of the patients administered cyclophosphamide. For the patient administered 5-fluorouracil, drug levels in his home environment were below the limit of detection. Conclusion: We demonstrated contamination of the home setting and exposure of family members to cyclophosphamide via the excreta of outpatient receiving chemotherapy. Exposure of the family member of the patient administered 5-fluorouracil was also demonstrated. These findings indicate the importance of strict precautions by the members of treated cancer patients as well as healthcare workers, to reduce the risk of exposure to antineoplastic drugs.
Impacts of modern transitions on thermal comfort in vernacular dwellings in warm-humid climate of Sugganahalli (India)
Authors: Shastry Vivek , Mani Monto , Tenorio Rosangela 
Published: October 2012

Sugganahalli, a rural vernacular community in a warm-humid region in South India, is under transition towards adopting modern construction practices. Vernacular local building elements like rubble walls and mud roofs are given way to burnt brick walls and reinforced cement concrete (RCC)/tin roofs. Over 60% of Indian population is rural, and implications of such transitions on thermal comfort and energy in buildings are crucial to understand. Vernacular architecture evolves adopting local resources in response to the local climate adopting passive solar designs. This paper investigates the effectiveness of passive solar elements on the indoor thermal comfort by adopting modern climate-responsive design strategies. Dynamic simulation models validated by measured data have also been adopted to determine the impact of the transition from vernacular to modern material-configurations. Age-old traditional design considerations were found to concur with modern understanding into bio-climatic response and climate-responsiveness. Modern transitions were found to increase the average indoor temperatures in excess of 7℃. Such transformations tend to shift the indoor conditions to a psychrometric zone that is likely to require active air-conditioning. Also, the surveyed thermal sensation votes were found to lie outside the extended thermal comfort boundary for hot developing countries provided by Givoni in the bio-climatic chart.
A systematic search for reports of site monitoring technique comparisons in clinical trials
Authors: Bakobaki Julie , Joffe Nicola , Burdett Sarah , Tierney Jayne , Meredith Sarah , Stenning Sally 
Published: October 2012

Background As part of a broader methodological programme of work around clinical trial monitoring, we wanted to evaluate the existing evidence for the effectiveness of different monitoring techniques. Purpose To identify and evaluate prospective studies of the effectiveness of different monitoring strategies. Methods A systematic search of MEDLINE from 1950 onwards, using free-text terms to identify relevant published studies. We intended to extract data on details of comparative techniques, monitoring findings identified by different techniques, and recommendations or identification of areas in need of further research made by authors. Results A total of 1222 published abstracts were identified and reviewed. Of these, nine articles described methods for quality control (QC) of clinical trial activities, and one article was identified that compared the same monitoring technique at two timepoints. None included a direct comparison of different monitoring techniques and findings. Limitations The search strategy was limited to MEDLINE. However, MEDLINE includes all the journals that tend to report trial methodological research. Conclusions There is a lack of published empirical data that compare monitoring strategies prospectively. Assessment of the usefulness and cost-effectiveness of monitoring techniques in a variety of clinical trial settings and indications is needed.
CD8 T cells induce T-bet–dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines
Authors: Serre Karine , Cunningham Adam F. , Coughlan Ruth E. , Lino Andreia C. , Rot Antal , Hub Elin , Moser Katrin , Manz Rudolf , Ferraro Alastair , Bird Roger , Toellner Kai-Michael , Demengeot Jocelyne , MacLennan Ian C. M. , Mohr Elodie 
Published: October 2012

Abstract
Antibody-forming cells (AFCs) expressing the chemokine receptor CXCR3 are recruited to sites of inflammation where they help clear pathogens but may participate in autoimmune diseases. Here we identify a mechanism that induces CXCR3 expression by AFC and germinal center (GC) B cells. This happens when CD8 T cells are recruited into CD4 T cell–dependent B-cell responses. Ovalbumin-specific CD4 T cells (OTII) were transferred alone or with ovalbumin-specific CD8 T cells (OTI) and the response to subcutaneous alum-precipitated ovalbumin was followed in the draining lymph nodes. OTII cells alone induce T helper 2-associated class switching to IgG1, but few AFC or GC B cells express CXCR3. By contrast, OTI-derived IFN-γ induces most responding GC B cells and AFCs to express high levels of CXCR3, and diverse switching to IgG2a, IgG2b, with some IgG1. Up-regulation of CXCR3 by GC B cells and AFCs and their migration toward its ligand CXCL10 are shown to depend on B cells' intrinsic T-bet, a transcription factor downstream of the IFN-γR signaling. This model clarifies how precursors of long-lived AFCs and memory B cells acquire CXCR3 that causes their migration to inflammatory foci.
Infectiousness of pigs infected by the Porcine Reproductive and Respiratory Syndrome virus (PRRSV) is time-dependent
Authors: Charpin Céline , Mahé Sophie , Keranflec’h André , Belloc Catherine , Cariolet Roland , Le Potier Marie-Frédérique , Rose Nicolas 
Published: October 2012

Abstract
The time-dependent transmission rate of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and the correlation between infectiousness, virological parameters and antibody responses of the infected pigs were studied in experimental conditions. Seven successive transmission trials involving a total of 77 specific pathogen-free piglets were carried out from 7 to 63 days post-inoculation (dpi). A semi-quantitative real time RT-PCR was developed to assess the evolution of the viral genome load in blood and nasal swabs from inoculated and contact pigs, with time. Virus genome in blood was detectable in inoculated pigs from 7 to 77 dpi, whereas viral genome shedding was detectable from nasal swabs from 2 to 48 dpi. The infectiousness of inoculated pigs, assessed from the frequency of occurrence of infected pigs in susceptible groups in each contact trial, increased from 7 to 14 dpi and then decreased slowly until 42 dpi (3, 7, 2, 1 and 0 pigs infected at 7, 14, 21, 28 and 42 dpi, respectively). These data were used to model the time-dependent infectiousness by a lognormal-like function with a latency period of 1 day and led to an estimated basic reproduction ratio, R
0 of 2.6 [1.8, 3.3]. The evolution of infectiousness was mainly correlated with the time-course of viral genome load in the blood whereas the decrease of infectiousness was strongly related to the increase in total antibodies.
The search for the gene mutations underlying enterotoxigenic Escherichia coli F4ab/ac susceptibility in pigs: a review
Authors: Schroyen Martine , Stinckens Anneleen , Verhelst Roderick , Niewold Theo , Buys Nadine 
Published: October 2012

Abstract
Diarrhoea due to enterotoxigenic Escherichia coli with fimbriae F4 (ETEC-F4) is an important problem in neonatal and just weaned piglets and hence for the pig farming industry. There is substantial evidence for a genetic basis for susceptibility to ETEC-F4 since not all piglets suffer from diarrhoea after an ETEC-F4 infection. It is assumed that the wild boar was originally ETEC-F4 resistant and that susceptibility towards ETEC arose after domestication. There are different phenotypes in the pig determined by which of the three existing F4 variants (F4ab, F4ac or F4ad) they are susceptible or resistant for. This suggests that several F4 receptors exist, expressed individually or in combination with each other on the brush border of the piglet’s small intestine. As such, the mucin-type glycoproteins (IMTGP) are described as F4ab/ac receptors, while the intestinal neutral glycospingolipid (IGLad) is proposed as an F4ad receptor. GP74 is a putative F4ab receptor. However, the specific genes that encode for the susceptibility are not yet known. In the past decades, linkage analyses revealed that the loci encoding for the receptor(s) for the two most frequent variants F4ab and F4ac were mapped to the 13th chromosome of the pig (Sus scrofa 13, SSC13). After fine mapping, the region of interest was mapped between two microsatellite markers, Sw207 and S0075, and interesting candidate genes surfaced. Numerous SNP analyses and a few expression studies on the three MUC-genes (MUC4, MUC13 and MUC20) and the transferrin receptor gene (TFRC) as well as on some other positional candidate genes have been performed in order to find the causative mutation for the ETEC-F4ab/ac receptor(s). However, until today, the exact mutation causing susceptibility to ETEC-F4 remains unknown.
Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils
Authors: Beloborodova Natalia , Bairamov Iskander , Olenin Andrei , Shubina Victoria , Teplova Vera , Fedotcheva Nadezhda 
Published: October 2012

Abstract

Background
Several low-molecular-weight phenolic acids are present in the blood of septic patients at high levels. The microbial origin of the most of phenolic acids in the human body was shown previously, but pathophysiological role of the phenolic acids is not clear. Sepsis is associated with the excessive production of reactive oxygen species (ROS) in both the circulation and the affected organs. In this work the influence of phenolic acids on ROS production in mitochondria and neutrophils was investigated.

Methods
ROS production in mitochondria and neutrophils was determined by MCLA- and luminol-dependent chemiluminescence. The rate of oxygen consumption by mitochondria was determined polarographically. The difference of electric potentials on the inner mitochondrial membrane was registered using a TPP+-selective electrode. The formation of phenolic metabolites in monocultures by the members of the main groups of the anaerobic human microflora and aerobic pathogenic bacteria was investigated by the method of gas chromatography–mass spectrometry.

Results
All phenolic acids had impact on mitochondria and neutrophils, the main producers of ROS in tissues and circulation. Phenolic acids (benzoic and cinnamic acids) producing the pro-oxidant effect on mitochondria inhibited ROS formation in neutrophils. Their effect on mitochondria was abolished by dithiothreitol (DTT). Phenyllactate and p-hydroxyphenyllactate decreased ROS production in both mitochondria and neutrophils. Bifidobacteria and lactobacilli produced in vitro considerable amounts of phenyllactic and p-hydroxyphenyllactic acids, Clostridia s. produced great quantities of phenylpropionic and p-hydroxyphenylpropionic acids, p-hydroxyphenylacetic acid was produced by Pseudomonas aeruginosa and Acinetobacter baumanii; and benzoic acid, by Serratia marcescens.

Conclusions
The most potent activators of ROS production in mitochondria are phenolic acids whose effect is mediated via the interaction with thiol groups. Among these are benzoic and cinnamic acids. Some phenolic acids, in particular phenyllactate and p-hydroxyphenyllactate, which decrease ROS production in mitochondria and neutrophils, can play a role of natural antioxidants. The results indicate that low-molecular weight phenolic acids of microbial origin participate in the regulation of the ROS production in both the circulation and tissues, thereby affecting the level of oxidative stress in sepsis.