bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing the professional identity of school counsellors in the Asia Pacific: Challenges and ways forward
Authors: Harrison Mark G. , Kee Low Poi 
Published: August 2024

AbstractBackgroundSchool counselling in the Asia Pacific region has experienced enormous development in the last few decades but faces many serious challenges as counsellors seek to respond to the needs of young people in a complex and fast‐changing environment.AimsThis article aimed to explore the challenges school counsellors face in finding a clear identity and sense of purpose.DiscussionWe outline the antecedents and consequences of a weak counsellor identity. We suggest that the future development of school counselling in the region rests on responding to the challenge of school counsellors finding a clear and robust identity by (1) adopting an ecological perspective and (2) developing culture‐specific, indigenous ways of counselling.ConclusionGiven that the development of school counselling in this region has a long way to go, we briefly sketch some research priorities for the years ahead, which may contribute to the realisation and articulation of a stronger professional identity for school counsellors.
Three‐dimensional printed model reconstruction in intraoperative use for glass penetrating facial tissue removal
Authors: Basovsky Filip , Capek Lukas , Kucera Ivo , Ptacek Frantisek , Kriz Jakub 
Published: August 2024

Key Clinical MessageIn the anatomically complex terrain of the head and neck, the use of 3D intraoperative models serves as an effective verification tool, determining the size, shape, and number of foreign bodies. This allows the main operator to maximize their capacities for careful wound revision and receive real‐time information about the remaining content of the sought‐after bodies.AbstractPenetrating foreign bodies of various origins in the head and neck are uncommon, but potentially hazardous injuries. Complete removal of foreign bodies from soft tissues is essential for optimal healing, minimizing complications, and significantly reducing the risk of the need for reoperation. Despite various technological systems and safeguards available, unintentionally retained surgically placed foreign bodies remain difficult to eliminate completely. A 34‐year‐old female patient with a cut on the right side of her face who was initially treated with sutures at a general surgical clinic presented for a follow‐up examination. A foreign body was verified subcutaneously on the anterior–posterior x‐ray image on the right side. Computed tomography confirmed a total of 7 foreign bodies with a density corresponding to dental enamel, distributed subcutaneously, subfascially, and intramuscularly in the right temporal region. As part of the preoperative preparation and analysis, the bone segment of the right temporal fossa with the zygomatic bone and the glass fragments were segmented from the CT data and printed on an SLA printer. The physical 3D models were autoclave sterilized and present during surgery. The position, shape, and number of each individual glass fragment was compared with 3D‐printed one. The benefits of producing 3D models of foreign bodies are undeniable, particularly in their perioperative comparison with the removed foreign bodies from wounds.
Polypoid endometriosis—An exceptional subtype of endometriosis mimicking an aggressive pelvic cancer
Authors: Mahiou Katia , Harizay Fara Tanjona , Lanouziere Morgane , Martz Olivia , Filipuzzi Laurence , Rousselet Jean‐Marc , Martin Laurent , Arnould Laurent , Vega Mathilde Funes De La , Bergeron Anthony 
Published: August 2024

Key Clinical MessagePolypoid endometriosis is a rare manifestation of endometriosis, which may mimic pelvic cancer. This subtype commonly encountered in post‐menopausal women may be wrongly mistaken for a neoplasm on clinical, radiological, perioperative or pathologic assessments leading to inadequate treatment.
Ovarian hemangioma: A rare encounter
Authors: Singh M. , Subedi P. , Adhikari B. , Sherchan A. , Bajrachrya A. , Mohanty S. , Dhakal H. P. 
Published: August 2024

Key Clinical MessageOvarian hemangioma, though rare and asymptomatic, can mimic malignant ovarian tumors, thus it is necessary for comprehensive histopathological and immunohistochemical evaluation for accurate diagnosis and appropriate management.
Spontaneous neck hematoma associated with parathyroid adenoma
Authors: Okano Mitsumasa , Yui Mitsuko , Teshima Masanori , Sakaguchi Kazuhiko 
Published: August 2024

Key Clinical MessageWe should consider parathyroid extraglandular bleeding for patients with acute neck pain and swelling. Evaluation of serum calcium and parathyroid hormone levels is crucial for a suspected neck hematoma associated with parathyroid adenoma.
A rare case of symmetrical drug‐related intertriginous and flexural erythema with tamoxifen use
Authors: Hussain Syed Ather , Berenji Ryan , Faisal Sarah , Ali Liaqat , Knavel Ashley 
Published: August 2024

Key Clinical MessageSymmetrical drug‐related intertriginous and flexural erythema is characterized by a diffuse symmetric rash of the gluteal and intertriginous areas with only one published report of association with tamoxifen. It is imperative for clinicians to recognize tamoxifen‐induced SDRIFE to avoid life‐threatening dermatologic complications, which can be resolved with discontinuation of tamoxifen.
Tert‐butyl hydroperoxide induces trabecular meshwork cells injury through ferroptotic cell death
Authors: Yan Xuejing , Liu Qian , Wu Shen , Fan Xiaowei , Teng Yufei , Wang Ningli , Zhang Jingxue 
Published: August 2024

AbstractTrabecular meshwork (TM) tissue has a crucial role in regulating aqueous humor circulation in the eye, thus maintaining normal intraocular pressure (IOP). TM dysfunction causes IOP elevation, which leads to glaucoma. To investigate biological changes in TM tissue in patients with glaucoma, we analyzed the mRNA expression microarray dataset, GSE27276. Gene ontology analysis indicated that redox microenvironment imbalance is among the main changes of TM tissue in patients with glaucoma. Subsequently, we induced oxidative stress in TM cells using the tert‐butyl hydroperoxide (tBHP) treatment, to generate in vivo and in vitro models, and conducted mRNA sequencing to identify genes with critical roles in maintaining the redox microenvironment balance. We found that the tBHP caused TM dysfunction in vivo, characterized by aqueous humor circulation resistance, IOP elevation, and TM cell death. Further, Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that ferroptosis signaling was enriched in tBHP‐treated TM cells. Consistently, in vitro analyses showed that levels of reactive oxygen species, ferric ion, and malondialdehyde were increased after the tBHP treatment, indicating TM cell ferroptosis. Furthermore, inhibiting ferroptosis alleviated tBHP‐induced TM cell injury. This study provides new insights suggesting that inhibition of ferroptosis has potential as a treatment for glaucoma.
Thiazolo[5,4‐d]Thiazole‐Linked Conjugated Porous Organic Polymers for Visible Light‐Driven C−N Bond Formation Reactions
Authors: He Yuan‐Yuan , Ma Zhang‐Peng , Liu Chun‐Hua , Zhu Yuan‐Yuan 
Published: August 2024

AbstractDue to their unique semiconducting properties, conjugated porous organic polymers (CPOPs) have garnered significant interest in various photocatalysis applications. In this study, we synthesize three thiazolo[5,4‐d]thiazole (TzTz)‐linked CPOPs with three polyaryl rigid cores of benzene (CPOP1), pyrene (CPOP2), and triazine (CPOP3). We investigated their efficacy in catalyzing visible light‐driven C−N bond formation reactions, including C−N cross‐couplings between aryl bromides and amines and amination reactions from aryl bromides and sodium azides. Among the three, only CPOP2, combined with NiCl2 or Ni(dtbbpy)Cl2, effectively facilitated these transformations. Notably, CPOP2 exhibited photocatalytic activities approximately six times higher than its small molecular counterpart C1 in both reactions. The CPOP catalyst was easily recovered through centrifugal separation and reused for five catalytic cycles with minimal loss of activity. Theoretical calculations revealed that the deliberate structural design of polyaryl moieties could effectively tune the energy gap, which is crucial for the photocatalytic activity in organic reactions. This study, therefore, demonstrates a novel application of TzTz‐linked CPOPs for heterogeneous photocatalytic organic transformations.
Discrete Macrocyclic Polymer Hosts‐Induced Cascade Luminescence Enhancement and Application in Bioimaging
Authors: Zhu Yu‐Qi , Chen Zhaojun , Chen Zhong‐Yuan , Zhou Zhi‐Wei , Bai Qian , Wu Ming‐Xue , Wang Xing‐Huo 
Published: August 2024

AbstractThe integration of polymers, supramolecular macrocycles and aggregation‐induced emission (AIE) molecules provides numerous possibilities for constructing various functional supramolecular systems. Herein, we constructed supramolecular assembled systems based on discrete macrocyclic polymer hosts via the cooperation of hydra‐headed macrocycles containing two or three pillar[5]arene units (defined as P2, P3), the block polymer F127 and AIE molecules (alkyl‐cyano modified tetraphenylethene, alkyl‐triazole‐cyano modified 9,10‐distyrylanthracene, defined as TPE‐(CN)4 and DSA‐(TACN)2). Compared with the binary assembly between hydra‐headed hosts or F127 and AIE molecules, cascaded supramolecular assembly‐induced emission enhancement (SAIEE) in aqueous solution was achieved in discrete macrocyclic polymer‐based supramolecular assembled systems. Considering the cascaded SAIEE performance, we have successfully applied discrete macrocyclic polymer‐based supramolecular assembled systems to bioimaging and constructed an artificial light‐harvesting system (LHs) to explore more potential applications. The supramolecular assembly form of discrete macrocyclic polymers hosts and AIE molecules proposed in this work provides new inspiration for the construction and application of high‐performance supramolecular luminescent systems.
Characteristics of Patients With Atherosclerotic Cardiovascular Disease in Belgium and Current Treatment Patterns for the Management of Elevated LDL‐C Levels
Authors: Maury Eléonore , Brouyère Samuel , Jansen Mieke 
Published: August 2024

ABSTRACTBackgroundDyslipidemia remains the major cause of atherosclerotic cardiovascular disease (ASCVD). Lipid management in patients with increased cardiovascular (CV) risk needs improvement across Europe, and data gaps are noticeable at the country level.HypothesisWe described the current treatment landscape in Belgium, hypothesizing that lipid management in patients with ASCVD remains inadequate and aiming to understand the reasons.MethodsUsing data from an anonymized primary care database in Belgium derived from 494 750 individuals, we identified those with any CV risk factor between November 2019 and October 2022 and described the clinical features of patients with ASCVD. The main outcomes were the proportion of patients (i) receiving lipid‐lowering therapies (LLTs), (ii) per low‐density lipoprotein cholesterol (LDL‐C) threshold, stratified per LLT, (iii) reaching the 2021 ESC recommended LDL‐C goals, and (iv) LDL‐C reduction per type of LLT was also determined.ResultsAmong 40 888 patients with very high CV risk, 24 859 had established ASCVD. Most patients with ASCVD were either receiving monotherapy (59.6%) or had no documented LLT (25.1%). Further, 64.2% of those with no documented LLT exhibited LDL‐C levels ≥ 100 mg/dL. Among common treatment options, one of the greatest improvements in LDL‐C levels was achieved with combination therapy of statin and ezetimibe, reducing LDL‐C levels by 41.5% (p < 0.0001). Yet, in this group, 24.8% of patients had still LDL‐C levels ≥ 100 mg/dL and only 20.7% were at goal.ConclusionOur study emphasizes the importance of developing strategies to help patients achieve their LDL‐C goals, with a focus on supporting the implementation of combination LLT in routine clinical practice.
How to Find a Fragment: Methods for Screening and Validation in Fragment‐Based Drug Discovery
Authors: Kirkman Tim , dos Santos Silva Catharina , Tosin Manuela , Bertacine Dias Marcio Vinicius 
Published: August 2024

AbstractFragment‐based drug discovery (FBDD) is a crucial strategy for developing new drugs that have been applied to diverse targets, from neglected infectious diseases to cancer. With at least seven drugs already launched to the market, this approach has gained interest in both academics and industry in the last 20 years. FBDD relies on screening small libraries with about 1000–2000 compounds of low molecular weight (about 300 Da) using several biophysical methods. Because of the reduced size of the compounds, the chemical space and diversity can be better explored than large libraries used in high throughput screenings. This review summarises the most common biophysical techniques used in fragment screening and orthogonal validation. We also explore the advantages and drawbacks of the different biophysical techniques and examples of applications and strategies.
Evaluation of 2D Tantalum Carbide MXene for Room to Mid‐temperature Thermoelectric Applications
Authors: Syamsai Ravuri , Vijay Vaiyapuri , Easwaran Senthil Kumar , Navaneethan Mani 
Published: August 2024

AbstractTantalum carbide MXene (Ta4C3Tx) were synthesized via HF etching of the Al intermediate layer from the parental tantalum aluminium carbide MAX phase (Ta4AlC3). The structural and vibrational studies confirm the formation of MXene from the MAX phase without disturbing the hexagonal crystal structure. The synthesized samples were analysed using XRD to understand the phase structure. In and out of plane vibrational properties were examined by Raman spectrometer. XPS confirms the successful HF etching of Al in MXene phase and all other elemental configurations. HR‐SEM and HR‐TEM revile the exfoliated layered structure of the MXene and hexagon diffraction pattern of the tantalum carbide MXene sample with increased d‐spacing. The TGA analysis demonstrated the thermal stability of the as‐synthesized post measured compounds. The synthesized tantalum carbide MXene shows stable thermoelectric properties over six thermal cycles. The temperature dependent transport properties were measured from 303 K to 803 K. Ta4C3Tx MXene shows a maximum Seebeck coefficient of 13.8 μV/K and a power factor of 1.88 μW/mK2 with the low lattice thermal conductivity of 5.42 W/mK at 803 K. In this present investigation, Tantalum carbide MXene demonstrated a decent thermoelectric property with high thermal cycling stability.
Corporate environmentalism and value creation: Investigating the role of shared independent directors in green technology adoption and financial performance
Authors: Khan Jalal , Fengyun Wu , Fawad Arshad 
Published: August 2024

AbstractUsing social network theory and resource dependence theory, this study undercovers whether independent directors' interlocks contribute directly to the corporate financial performance of Chinese firms or indirectly through green technology innovation. Furthermore, we scrutinize how the environmental protection management system affects the path between independent directors' interlocks and green technology innovation. Using a sample of 4902 listed firms in China over the period of 2010–2022, the results indicate that firms possess interlocks through their independent directors play a crucial role in fostering performance and developing low‐carbon technologies. With an environmental protection management system, the impact of the independent directors' interlocks on corporate green technology innovation is stronger, indicating the significant role of corporate internal environmental context. This study offers practical implications for firms and policymakers by demonstrating how independent director interlocks can simultaneously advance corporate and national economic and environmental objectives.
The moderating role of investor sentiments between sustainability reporting and firm reputation. Evidence from Chinese listed firms
Authors: Abideen Zain Ul 
Published: August 2024

AbstractThis study explores the relationship between sustainability reporting, investor sentiments, and firm reputation in the Chinese stock market. Utilizing panel data from 2018 to 2023 on non‐financial A‐share firms in China, this study employs OLS regression and advanced techniques to ensure robustness, including tests for heteroskedasticity and addressing endogeneity concerns through 2SLS, and potentially the two‐step GMM approach. Analysis exhibits a positive relationship between sustainability reporting, investor sentiments, and firm reputation. Strong sustainability practices correlate with more positive investor sentiment and enhanced firm reputation, aligning with sustainable development principles. Limitations include the restricted data timeframe, suggesting broader insights could be gained by extending the analysis period. Additionally, the study's focus on brand equity as a metric for reputation may overlook other facets. Future research could explore alternative reputation metrics and measurement methods. Integrating environmental, social, and governance reporting into corporate strategies can drive long‐term value creation and sustainable development, offering actionable insights for policymakers, investors, and corporate decision‐makers. This study contributes unique insights into how sustainability reporting influences investor sentiment and firm reputation within the Chinese stock market context, leveraging the SR framework and focusing on firms in China, thus providing valuable perspectives on a dynamic market.
Schistosoma excretory/secretory products: an untapped library of tolerogenic immunotherapeutics against food allergy
Authors: Rogers Madeleine , Kamath Sandip , McManus Donald , Jones Malcolm , Gordon Catherine , Navarro Severine 
Published: August 2024

AbstractFood allergy (FA) is considered the ‘second wave’ of the allergy epidemic in developed countries after asthma and allergic rhinitis with a steadily growing burden of 40%. The absence of early childhood pathogen stimulation embodied by the hygiene hypothesis is one explanation, and in particular, the eradication of parasitic helminths could be at play. Infections with parasites Schistosoma spp. have been found to have a negative correlation with allergic diseases. Schistosomes induce regulatory responses to evade immune detection and ensure their long‐term survival. This is achieved via excretory/secretory (E/S) products, consisting of proteins, lipids, metabolites, nucleic acids and extracellular vesicles, representing an untapped therapeutic avenue for the treatment of FA without the unpleasant side‐effects and risks associated with live infection. Schistosome‐derived immunotherapeutic development is in its infancy and novel discoveries are heavily technology dependent; thus, it is essential to better understand how newly identified molecules interact with host immune systems to ensure safety and successful translation. This review will outline the identified Schistosoma‐derived E/S products at all life cycle stages and discuss known mechanisms of action and their ability to suppress FA.
Micritisation products in the inner ramp settings of the Abu Dhabi Lagoon
Authors: Teillet Thomas , Harkat Mohamed , Hachmann Kai , Garuglieri Elisa , Chandra Viswasanthi , Daffonchio Daniele , Sánchez‐Román Mónica , Vahrenkamp Volker 
Published: August 2024

AbstractIn numerous carbonate reservoirs in the Middle East, peloidal packstone‐grainstones are rock types with excellent pore storage potential in micritised microporous grains. However, the origin of the micro‐porosity and associated micro‐spar remains unclear, and one hypothesis is that both micro‐spar and porosity originate from early marine micritisation and were later altered during subsequent diagenesis (i.e. cementation recrystallisation). The south‐eastern coast of the Arabian Gulf is recognised as a modern, albeit miniature, depositional setting analogue to Mesozoic carbonate sequences that form the supergiant reservoirs of the Middle East. Using optical microscopy, backscattered scanning electron microscopy and carbon and oxygen stable isotope analysis the present study aims to document the nature of internal microstructures of micritic envelopes and peloids from the surface sediments of various sub‐environments of the Abu Dhabi Lagoon. Results highlight a high degree of diversity and heterogeneities of most micritic envelopes and peloids observed across the sub‐environments. First, carbonate grains from ooid and bioclastic shoals show the simpler micritic envelopes. Here, micritic envelopes and peloids show sparse microborings filled with banded radial aragonite cement, a pattern of production of cryptocrystalline texture (e.g. micritisation) that is similar to the sequence of micritisation observed in the modern sediment of the Great Bahama Bank. Conversely, in the subtidal and intertidal zones with mangroves or seagrass, the micritic envelopes and peloids are much more complex and show multiple generations of microborings that are either empty or filled with carbonate materials of varying types (i.e. various cements, fragments, etc.).
Caregiver burden and depression among lesbian, gay, bisexual, and other nonheterosexual individuals in the United States: Analysis of BRFSS 2015–2018
Authors: Xie Hui , Wen Chi , Li Yannan , Theodoropoulos Nicholas , Wang Qian 
Published: August 2024

AbstractThe number of caregivers in the US continues to rise. However, the epidemiology and mental health among lesbian, gay, bisexual, and other nonheterosexual (LGB+) caregivers remain unknown. We aimed to characterize the epidemiology of caregiving burden/information among LGB+ caregivers in the United States, as well as to examine depression and related risk factors. By using the data from the 2015–2018 Behavioral Risk Factor Surveillance System (BRFSS), we conducted weighted hierarchical logistic regression models to explore the associations between depression, caregiving information, health behaviors, sex, and sexual orientation among an estimated population of 9,521,313 LGB+ caregivers. Among the caregivers aged 18–79 years, 4.81% identified as LGB+. Notably, 19.21% of the caregivers reported experiencing depression, with distinctive rates observed among male LGB+ caregivers and female LGB+ caregivers were 38.22% and 51.43%, respectively. Meanwhile, nearly 45.00% of male LGB+ caregivers offered care to nonrelatives, a significantly higher rate compared to their heterosexual counterparts (23.32%, p < 0.001). The logistic regression models revealed that both male LGB+ caregivers (odds ratio [OR]: 3.56; 95% confidence interval [CI]: 1.45–8.77) and female LGB+ caregivers (OR: 2.38; 95% CI: 1.00–5.63) exhibited a higher likelihood of reporting depression compared to male heterosexual peers. Additionally, caregivers seeking support services for their caregiving responsibilities were more likely to report depression (OR: 1.47; 95% CI: 1.12–1.94). Our study revealed higher caregiving burden and depression among LGB+ caregivers in the United States, warranting further research and targeted support to address their unique challenges and improve services to caregivers.