bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lidar Investigation of Knockdhu Promontory and its Environs, County Antrim, Northern Ireland
Authors: McNeary Rory W. A. 
Published: June 2014

ABSTRACTA high‐resolution aerial lidar survey (up to 40 points m‐2) has been carried out in the environs of Knockdhu Promontory in the Antrim Uplands, which is recognized as one of Northern Ireland's most important relict multiperiod archaeological landscapes. This lidar survey was amongst the first such surveys commissioned specifically for archaeological purposes in Northern Ireland and has helped to re‐evaluate the archaeological landscape character of a 9 km2 study area and inform future conservation studies. Sampled ground observation was undertaken in an attempt to provide a higher degree of interpretive integrity. These field observation exercises also highlighted the importance of the high vertical resolution of the data (0.05 m at 2σ (95% confidence level)) in delineating extremely subtle upstanding earthwork features that had hitherto gone unnoticed. Much of the archaeological evidence identified can be broadly ascribed to the early post‐medieval period (ad 1599–1750); this includes field boundaries, cultivation furrows, enclosures, transhumance huts, abandoned settlements and associated pathways, but the higher ground of the Antrim Plateau in this locality is also characterized by evidence of prehistoric activities and substantial earthworks survive such as the ‘Linford Barrows’ and ‘Knockdhu Promontory Fort’. The lidar study has identified as many as 285 previously unrecorded potential archaeological sites and amended existing records within the Northern Ireland Sites and Monuments Record (NISMR) and has proved transformational as a technique to ‘open up’ the Ulster uplands for archaeological study. Copyright © 2014 John Wiley & Sons, Ltd.
Macrophage‐Derived Delta‐like Protein 1 Enhances Interleukin‐6 and Matrix Metalloproteinase 3 Production by Fibroblast‐like Synoviocytes in Mice With Collagen‐Induced Arthritis
Authors: Sekine Chiyoko , Nanki Toshihiro , Yagita Hideo 
Published: June 2014

ObjectiveWe previously reported that blockade of the Notch ligand delta‐like protein 1 (DLL‐1) suppressed osteoclastogenesis and ameliorated arthritis in a mouse model of rheumatoid arthritis (RA). However, the mechanisms by which joint inflammation were suppressed have not yet been revealed. This study was undertaken to determine whether DLL‐1 regulates the production of RA‐related proinflammatory cytokines.MethodsJoint cells from mice with collagen‐induced arthritis (CIA) and mouse fibroblast‐like synoviocytes (FLS) were cultured with or without stimuli in the presence of neutralizing antibodies against Notch ligands, and the production of proinflammatory cytokines was determined by enzyme‐linked immunosorbent assay. The expression of Notch receptors and ligands on mouse joint cells was determined by flow cytometry.ResultsThe production of interleukin‐6 (IL‐6) and granulocyte–macrophage colony‐stimulating factor (GM‐CSF) by mouse joint cells with or without stimulation was suppressed by DLL‐1 blockade. DLL‐1 blockade also suppressed the levels of IL‐6 and matrix metalloproteinase 3 (MMP‐3) in the joint fluid in a mouse model of RA. However, the production of tumor necrosis factor α and IL‐1β was not suppressed by DLL‐1 blockade. The production of IL‐6 and MMP‐3 by mouse FLS was enhanced by DLL‐1 stimulation as well as Notch‐2 activation. Among joint cells, DLL‐1 was not expressed on mouse FLS but was expressed on macrophages.ConclusionThese results suggest that the interaction of DLL‐1 on mouse joint macrophages with Notch‐2 on mouse FLS enhances the production of IL‐6 and MMP‐3. Therefore, suppression of IL‐6, GM‐CSF, and MMP‐3 production by DLL‐1 blockade might be responsible for the amelioration of arthritis in a mouse model of RA.
Citrullination of Epithelial Neutrophil–Activating Peptide 78/CXCL5 Results in Conversion From a Non–Monocyte‐Recruiting Chemokine to a Monocyte‐Recruiting Chemokine
Authors: Yoshida Ken , Korchynskyi Olexandr , Tak Paul P. , Isozaki Takeo , Ruth Jeffrey H. , Campbell Phillip L. , Baeten Dominique L. , Gerlag Danielle M. , Amin M. Asif , Koch Alisa E. 
Published: June 2014

ObjectiveTo examine whether the citrullinated chemokines epithelial neutrophil–activating peptide 78 (ENA‐78)/CXCL5, macrophage inflammatory protein 1α/CCL3, and monocyte chemotactic protein 1/CCL2 are detected in the biologic fluid of patients with rheumatoid arthritis (RA), and if so, to determine the biologic activities of these chemokines.MethodsRecombinant human chemokines were citrullinated by peptidylarginine deiminase. Enzyme‐linked immunosorbent assays were performed to measure the concentrations of citrullinated chemokines in sera from patients with rheumatoid arthritis (RA) and normal individuals and in synovial fluid from patients with RA, patients with osteoarthritis (OA), and patients with other inflammatory rheumatic diseases. The correlation between the citrullinated chemokine levels and clinical data was analyzed. Monocyte and neutrophil chemotaxis assays were performed, and native (noncitrullinated) or citrullinated ENA‐78/CXCL5 was injected into mouse knees to evaluate the biologic activities of these chemokines.ResultsThe concentration of citrullinated ENA‐78/CXCL5 was significantly higher in RA sera and SF than in normal sera and in SF from patients with other rheumatic diseases including OA. In RA SF, a strong correlation between the amount of citrullinated ENA‐78/CXCL5 and the C‐reactive protein level or the erythrocyte sedimentation rate was observed. Citrullinated ENA‐78/CXCL5 induced monocyte chemotaxis via CXCR1 and CXCR2, while noncitrullinated ENA‐78/CXCL5 did not. In a mouse model of inflammatory arthritis, citrullinated ENA‐78/CXCL5 induced more severe inflammation and recruited more monocytes than did noncitrullinated ENA‐78/CXCL5.ConclusionCitrullinated ENA‐78/CXCL5 is highly correlated with RA disease activity and, unlike noncitrullinated ENA‐78/CXCL5, recruits monocytes. These results indicate that citrullinated ENA‐78/CXCL5 may exert previously unrecognized inflammatory properties in RA by recruiting monocytes to inflamed joint tissue.
Sequence‐Specific DNA Alkylation by Tandem Py–Im Polyamide Conjugates
Authors: Taylor Rhys Dylan , Kawamoto Yusuke , Hashiya Kaori , Bando Toshikazu , Sugiyama Hiroshi 
Published: June 2014

AbstractTandem N‐methylpyrroleN‐methylimidazole (PyIm) polyamides with good sequence‐specific DNA‐alkylating activities have been designed and synthesized. Three alkylating tandem PyIm polyamides with different linkers, which each contained the same moiety for the recognition of a 10 bp DNA sequence, were evaluated for their reactivity and selectivity by DNA alkylation, using high‐resolution denaturing gel electrophoresis. All three conjugates displayed high reactivities for the target sequence. In particular, polyamide 1, which contained a β‐alanine linker, displayed the most‐selective sequence‐specific alkylation towards the target 10 bp DNA sequence. The tandem PyIm polyamide conjugates displayed greater sequence‐specific DNA alkylation than conventional hairpin PyIm polyamide conjugates (4 and 5). For further research, the design of tandem PyIm polyamide conjugates could play an important role in targeting specific gene sequences.
New strategy for expression of recombinant hydroxylated human collagen α1(III) chains in Pichia pastorisGS115
Authors: He Jing , Ma Xiaoxuan , Zhang Fenglong , Li Linbo , Deng Jianjun , Xue Wenjiao , Zhu Chenhui , Fan Daidi 
Published: June 2014

AbstractType III collagen is one of the most abundant proteins in the human body, which forms collagen fibrils and provides the stiff, resilient characteristics of many tissues. In this paper, a new method for secretory expression of recombinant hydroxylated human collagen α1(III) chain in Pichia pastoris GS115 was applied. The gene encoding for full‐length human collagen α1(III) chain (COL3A1) without N‐terminal propeptide and C‐terminal propeptide was cloned in the pPIC9K expression vector. The prolyl 4‐hydroxylase (P4H, EC 1.14.11.2) α‐subunit (P4Hα) and β‐subunit (P4Hβ) genes were cloned in the same expression vector, pPICZB. Fluorogenic quantitative PCR indicates that COL3A1 and P4H genes have been expressed in mRNA level. SDS‐PAGE shows that secretory expression of recombinant human collagen α1(III) chain was successfully achieved in P. pastoris GS115. In addition, the result of amino acids composition analysis shows that the recombinant human collagen α1(III) chain contains hydroxyproline by coexpression with the P4H. Furthermore, liquid chromatography coupled with tandem mass spectrometry analysis demonstrates that proline residues of the recombinant human collagen α1(III) chain were hydroxylated in the X or Y positions of Gly–X–Y triplets.
Was zählt der Preis? Dogmengeschichte und Wissensgeschichte der Ökonomie
Authors: Speich Chassé Daniel 
Published: June 2014

AbstractWhat’s in a Price? History of Economic Ideologies vs. History of Economic Ideas. This paper suggests applying the approach of a historical epistemology to the field of economics. We observe that an assumedly fundamental opposition between the market and the state dominates popular images of the history of economic ideas. Two conflicting ideologies are roughly assigned to the two opposing sides in the Cold War. To this historical narrative the paper opposes a different view. The argument is that when taking the technical practices of economic knowledge production in the twentieth century into view, similarities abound across ideological ruptures. The chief characteristic change in the recent history of economics was a radical turn towards quantification, measurement, and mathematical modelling. A historical epistemology of economics could show how deeply both, admirers of the state and of the market, share a history. The paper concludes that to‐date critique of political economy should also take into consideration a critical perspective towards the unfolding of this measurement revolution in the social sciences.
Kommentar: The Economic or the Economy? – Reflections on the Objects of Historical Epistemology
Authors: Tellmann Ute 
Published: June 2014

AbstractIn the recent decade the perspectives of historical epistemology have turned economic practices into a novel object of study: the focus lies on how discourses, techniques of measurement and valuation produce economic facts.1 The research on the historical epistemologies of economic facts belongs to a broader scholarly endeavor that takes place in cultural anthropology, social theory, literary studies, political theory and history. This interdisciplinary work brings to light how deeply economic issues are constituted by intermingling a set of cultural, political, technical and legal distinctions, which distinguish what counts as properly economic from what does not.2 In this perspective, the very definition of economy becomes a hybrid and contentious affair.The central theoretical question for the historical epistemology and cultural anthropology of economy is currently how to conceptualize the link between epistemic practices and acts of ‘doing the economy’. This special issue on the Historical Episte mology of the Economic pushes us to think about this crucial link. Monika Dommann, Daniel Speich Chassé and Mischa Suter explore different modes of approaching the interlacing of epistemology and economy. These modes can be discussed under the following headings: 1) Pragmatics and Poetologies of Knowledge, 2) Economic Discourses and Epistemic Techniques, 3) Boundaries of Economy. On the basis of the richness of the historical material and the finely grained arguments that these papers bring forth, I will elaborate on the conceptualization of these linkages between epistemology and economy. My discussion culminates in the attempt to clarify an analytical distinction that is freely used in this special issue but that deserves further discussion: the distinction between the economic and the economy as an object of historical epistemology. My question is, does it matter if we write a historical epistemology of the economic or of the economy? What distinction do we wish to make by juxtaposing these two?
Atmospheric vs. anaerobic processing of metabolome samples for the metabolite profiling of a strict anaerobic bacterium, Clostridium acetobutylicum
Authors: Lee Sang‐Hyun , Kim Sooah , Kwon Min‐A , Jung Young Hoon , Shin Yong‐An , Kim Kyoung Heon 
Published: June 2014

ABSTRACTWell‐established metabolome sample preparation is a prerequisite for reliable metabolomic data. For metabolome sampling of a Gram‐positive strict anaerobe, Clostridium acetobutylicum, fast filtration and metabolite extraction with acetonitrile/methanol/water (2:2:1, v/v) at −20°C under anaerobic conditions has been commonly used. This anaerobic metabolite processing method is laborious and time‐consuming since it is conducted in an anaerobic chamber. Also, there have not been any systematic method evaluation and development of metabolome sample preparation for strict anaerobes and Gram‐positive bacteria. In this study, metabolome sampling and extraction methods were rigorously evaluated and optimized for C. acetobutylicum by using gas chromatography/time‐of‐flight mass spectrometry‐based metabolomics, in which a total of 116 metabolites were identified. When comparing the atmospheric (i.e., in air) and anaerobic (i.e., in an anaerobic chamber) processing of metabolome sample preparation, there was no significant difference in the quality and quantity of the metabolomic data. For metabolite extraction, pure methanol at −20°C was a better solvent than acetonitrile/methanol/water (2:2:1, v/v/v) at −20°C that is frequently used for C. acetobutylicum, and metabolite profiles were significantly different depending on extraction solvents. This is the first evaluation of metabolite sample preparation under aerobic processing conditions for an anaerobe. This method could be applied conveniently, efficiently, and reliably to metabolome analysis for strict anaerobes in air. Biotechnol. Bioeng. 2014;111: 2528–2536. © 2014 Wiley Periodicals, Inc.
The effect of metformin on breast cancer outcomes in patients with type 2 diabetes
Authors: Oppong Bridget A. , Pharmer Lindsay A. , Oskar Sabine , Eaton Anne , Stempel Michelle , Patil Sujata , King Tari A. 
Published: June 2014

AbstractObservational data suggest that metformin use decreases breast cancer (BC) incidence in women with diabetes; the impact of metformin on BC outcomes in this population is less clear. The purpose of this analysis was to explore whether metformin use influences BC outcomes in women with type 2 diabetes. Prospective institutional databases were reviewed to identify patients with diabetes who received chemotherapy for stages I–III BC from 2000 to 2005. Patients diagnosed with diabetes before or within 6 months of BC diagnosis were included. Males and those with type I, gestational, or steroid‐induced diabetes were excluded. Patients were stratified based on metformin use, at baseline, defined as use at time of BC diagnosis or at diabetes diagnosis if within 6 months of BC diagnosis. Kaplan–Meier methods were used to estimate rates of recurrence‐free survival (RFS), overall survival (OS), and contralateral breast cancer (CBC). We identified 313 patients with diabetes who received chemotherapy for BC, 141 (45%) fulfilled inclusion criteria and 76 (54%) used metformin at baseline. There were no differences in clinical presentation or tumor characteristics between metformin users and nonusers. At a median follow‐up of 87 months (range, 6.9–140.4 months), there was no difference in RFS (P = 0.61), OS (P = 0.462), or CBC (P = 0.156) based on metformin use. Five‐year RFS was 90.4% (95% CI, 84–97) in metformin users and 85.4% (95% CI, 78–94) in nonusers. In this cohort of patients with type 2 diabetes receiving systemic chemotherapy for invasive BC, the use of metformin was not associated with improved outcomes.
Specific Maltose Derivatives Modulate the Swarming Motility of Nonswarming Mutant and Inhibit Bacterial Adhesion and Biofilm Formation by Pseudomonas aeruginosa
Authors: Shetye Gauri S. , Singh Nischal , Jia Changqing , Nguyen Chan D. K. , Wang Guirong , Luk Yan‐Yeung 
Published: June 2014

AbstractWe have demonstrated that specific synthetic maltose derivatives activate the swarming motility of a Pseudomonas aeruginosa nonswarming mutant (rhlA) at low concentration, but inhibit it at high concentration. Although these molecules are not microbicidal, active maltose derivatives with bulky hydrocarbon groups inhibited bacterial adhesion, and exhibited biofilm inhibition and dispersion (IC50 ∼20 μM and DC50 ∼30 μM, respectively). Because the swarming motility of the rhlA mutant is abolished by the lack natural rhamnolipids, the swarming activation suggests that maltose derivatives are analogues of rhamnolipids. Together, these results suggest a new approach of controlling multiple bacterial activities (bacterial adhesion, biofilm formation, and swarming motility) by a set of disaccharide‐based molecules.
Controlled Thermal Annealing Tunes the Photoelectrochemical Properties of Nanochanneled Tin‐Oxide Structures
Authors: Palacios‐Padrós Anna , Altomare Marco , Lee Kiyoung , Díez‐Pérez Ismael , Sanz Fausto , Schmuki Patrik 
Published: June 2014

AbstractWe study the effect of thermal annealing conditions (up to 400 °C) and atmospheres (air, Arand O2) on a newly developed nanochannel tin‐oxide structure. The nanochanneled structures were prepared by self‐organized anodization of metallic tin. Thermal annealing conditions have a strong impact on the crystallinity and content of Sn2+ defects present in the structure, and thus have a strong influence on the photoresponse characteristics of the films. Photocurrent measurements show that films annealed at 200 °C in Ar atmosphere exhibit a band gap as low as 2.4 eV and a photoresponse in the visible range. This effect is ascribed to a large content of Sn2+ defects in the structure and the improved crystallinity of the films annealed at this temperature. On the contrary, the Sn2+ content is decreased when annealing at 400 °C under aerobic conditions, which correlates with a shift in the film band gap to 3.2 eV, closer to the reported value for pure SnO2 (3.6 eV).
Pulse‐Plating of Mn–Cu–ZnO for Supercapacitors: A Study Based on Soft X‐ray Fluorescence and Absorption Microspectroscopy
Authors: Bozzini Benedetto , Gianoncelli Alessandra , Mele Claudio , Abyaneh Majid Kazemian , Jezersěk David , Sgura Ivonne , Kiskinova Maya 
Published: June 2014

AbstractThis paper reports on the electrodeposition of Mn–Cu–ZnO for hybrid supercapacitors. This material exhibits a dual structure consisting of Mn‐rich highly active, but poorly electronically conducting, grains, which are locked by a Cu‐rich highly conductive network that also possesses some degree of charge‐storage capacity. This work focuses on morphological, compositional, and chemical‐state distributions with submicrometer lateral resolution. This information, which is crucial because doping distribution controls supercapacitor performance, has been obtained by combining electrochemical and in situ Raman measurements with synchrotron‐based X‐ray fluorescence and absorption microspectroscopy. Using a microfabricated thin‐layer three‐electrode microcell, we followed the morphochemical changes at different electrodeposition stages and found that pulse‐plating allows the growth of Mn‐ and Cu‐doped ZnO as self‐organized structures with a consistent spatially stable composition distribution.
Systematic Control of the Excited‐State Dynamics and Carrier‐Transport Properties of Functionalized Benzo[ghi]perylene and Coronene Derivatives
Authors: Hirayama Sunao , Sakai Hayato , Araki Yasuyuki , Tanaka Minako , Imakawa Masaki , Wada Takehiko , Takenobu Taishi , Hasobe Taku 
Published: June 2014

AbstractA series of benzo[ghi]perylene (Bp) and coronene (Cor) derivatives substituted with electron‐withdrawing methoxycarbonyl (COOMe) or electron‐donating methoxyl (MeO) groups was synthesized. The electrochemical, spectroscopic, and photophysical properties of these compounds were investigated by cyclic voltammetry, steady‐state and time‐resolved spectroscopy, and quantum‐yield measurements. Introduction of suitable substituents onto the aromatic rings enabled control of electrochemical and spectroscopic behavior. Examination of excited‐state dynamics revealed that fluorescence quantum yields increased with increasing number of COOMe groups in both Bp and Cor derivatives, consistent with the findings of DFT calculations. Single‐crystal analysis allowed the performance of field‐effect transistors containing single crystals of the derivatives to be rationalized.
ChemInform Abstract: Synthesis and Properties of Cobalt Sulfide Phases: CoS2 and Co9S8.
Authors: Kumar Nitesh , Raman Natarajan , Sundaresan Athinarayanan 
Published: June 2014

AbstractSingle phase CoS2 nanoparticles are prepared by thermal decomposition of the cobalt—(H2N)2C=S (tu) complex [Co(tu)4(NO3)2] at 400 °C.
ChemInform Abstract: Direct Growth of NiCo2S4 Nanotube Arrays on Nickel Foam as High‐Performance Binder‐Free Electrodes for Supercapacitors.
Authors: Pu Jun , Wang Tingting , Wang Haiyang , Tong Yao , Lu Chenchen , Kong Wei , Wang Zhenghua 
Published: June 2014

AbstractNiCo2S4 nanotube arrays are grown by a two‐step hydrothermal process involving the loading of HCl cleaned Ni foam with precursors CoCl2 and NiCl2 (autoclave, 100 °C, 8 h) followed by adding the precursor foam to an aqueous Na2S solution (autoclave, 120 °C, 4 h).
ChemInform Abstract: Synthesis and Magnetic Properties of β‐KVOF3.
Authors: Donakowski Martin D. , Lu Hongcheng , Gautier Romain , Saha Rana , Sundaresan A. , Poeppelmeier Kenneth R. 
Published: June 2014

Abstractβ‐KVOF3 is prepared by in‐situ reduction under hydrothermal conditions using a mixture of V2O5 and KBr (3:2) in aq.
ChemInform Abstract: New Routes to Synthesizing an Ordered Perovskite CaCu3Fe2Sb2O12 and Its Magnetic Structure by Neutron Powder Diffraction.
Authors: Larregola Sebastian A. , Zhou Jianshi , Alonso Jose A. , Pomjakushin Vladimir , Goodenough John B. 
Published: June 2014

AbstractA high‐quality A,B‐site‐ordered double perovskite CaCu3Fe2Sb2O12 is prepared at ambient pressure by two routes, a wet‐chemical procedure involving a mixture of CuO, Fe(NO3)3.9H2O, Ca(NO3)2, and Sb2O3 in citric acid and few HNO3 which is slowly evaporated and decomposed at 550 °C followed by a complex heating schedule (≈92% yield) and, secondly, by activating an oxide mixture of CuO, Fe2O3, Sb2O3, and CaCO3 by ball milling also followed by a complex heating schedule in which the amorphous material recrystallizes at < 820 °C (perovskite phase yield of 97%).
ChemInform Abstract: Ruthenium(V) Oxides from Low‐Temperature Hydrothermal Synthesis.
Authors: Hiley Craig I. , Lees Martin R. , Fisher Janet M. , Thompsett David , Agrestini Stefano , Smith Ronald I. , Walton Richard I. 
Published: June 2014

AbstractCa1.5Ru2O7 (I), SrRu2O6 (II), and Ba2Ru3O9(OH) (III) are hydrothermally synthesized from aqueous mixtures of KRuO4 and MO2 (M: Ca, Sr, Ba; autoclave, 200 °C, 24 h).
ChemInform Abstract: Enantioselective Organocatalytic Oxa‐Michael Addition of Oximes to β‐CF3‐β‐Disubstituted Nitroalkenes: Efficient Synthesis of β‐Amino‐α‐trifluoromethyl Alcohols.
Authors: Liu Feng‐Lei , Chen Jia‐Rong , Feng Bin , Hu Xiao‐Qiang , Ye Li‐Hua , Lu Liang‐Qiu , Xiao Wen‐Jing 
Published: June 2014

AbstractThe first organocatalyzed, asymmetric oxa‐Michael addition of oximes to β‐CF3‐β‐substituted nitroalkenes (I) furnishing CF3‐containing oxime ethers (III) (13 examples) in high yields and enantioselectivities is described.
ChemInform Abstract: Selective Synthesis of Indazoles and Indoles via Triazene—Alkyne Cyclization Switched by Different Metals.
Authors: Fang Yan , Wang Chengming , Su Shengqin , Yu Haizhu , Huang Yong 
Published: June 2014

AbstractThe copper‐mediated oxidative cyclization of alkynyl triazenes (I) leads to indazoles of type (II), whereas, the silver‐mediated reaction affords indoles of type (IV).