bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family needs and involvement in the intensive care unit: a literature review
Authors: Al‐Mutair Abbas Saleh , Plummer Virginia , O'Brien Anthony , Clerehan Rosemary 
Published: March 2013

Aims and objectivesTo understand the needs of critically ill patient families', seeking to meet those needs and explore the process and patterns of involving family members during routine care and resuscitation and other invasive procedures.MethodsA structured literature review using Cumulative Index to Nursing and Allied Health Literature, Pubmed, Proquest, Google scholar, Meditext database and a hand search of critical care journals via identified search terms for relevant articles published between 2000 and 2010.ResultsThirty studies were included in the review either undertaken in the Intensive Care Unit or conducted with critical care staff using different methods of inquiry. The studies were related to family needs; family involvement in routine care; and family involvement during resuscitation and other invasive procedures. The studies revealed that family members ranked both the need for assurance and the need for information as the most important. They also perceived their important needs as being unmet, and identified the nurses as the best staff to meet these needs, followed by the doctors. The studies demonstrate that both family members and healthcare providers have positive attitudes towards family involvement in routine care. However, family members and healthcare providers had significantly different views of family involvement during resuscitation and other invasive procedures.ConclusionMeeting Intensive Care Unit family needs can be achieved by supporting and involving families in the care of the critically ill family member. More emphasis should be placed on identifying the family needs in relation to the influence of cultural values and religion held by the family members and the organisational climate and culture of the working area in the Intensive Care Unit.
The Vestan cataclysm: Impact‐melt clasts in howardites and the bombardment history of 4 Vesta
Authors: Cohen Barbara A. 
Published: March 2013

AbstractCrystalline impact‐melt samples were created in high‐temperature environments by relatively large craters and, as such, give additional constraints on the nature of the impacts that created them. This article provides new40Ar‐39Ar ages of impact‐melt clasts in howardites and shows that these clasts formed on theHEDparent body, 4 Vesta, within the time period 3.3–3.8 Ga. Rather than resulting from an increased number of impacts, however, impact‐melted material in howardites may result from unusually high‐velocity impacts occurring in the asteroid belt during this period. This scenario is similar to the late heavy bombardment of the Moon, pointing to an unusual dynamical event at this time across the inner solar system. Therefore, impact‐melt rocks in howardites uniquely record a Vestan cataclysm.
Putrescine catabolism is a metabolic response to several stresses in Escherichia coli
Authors: Schneider Barbara L. , Hernandez V. James , Reitzer Larry 
Published: March 2013

SummaryGenes whose products degrade arginine and ornithine, precursors of putrescine synthesis, are activated by either regulators of the nitrogen‐regulated (Ntr) response or σS‐RNA polymerase. To determine if dual control regulates a complete putrescine catabolic pathway, we examined expression of patA and patD, which specify the first two enzymes of one putrescine catabolic pathway. Assays of PatA (putrescine transaminase) activity and β‐galactosidase from cells with patA–lacZ transcriptional and translational fusions indicate dual control of patA transcription and putrescine‐stimulated patA translation. Similar assays for PatD indicate that patD transcription required σS‐RNA polymerase, and Nac, an Ntr regulator, enhanced the σS‐dependent transcription. Since Nac activation via σS‐RNA polymerase is without precedent, transcription with purified components was examined and the results confirmed this conclusion. This result indicates that the Ntr regulon can intrude into the σS regulon. Strains lacking both polyamine catabolic pathways have defective responses to oxidative stress, high temperature and a sublethal concentration of an antibiotic. These defects and the σS‐dependent expression indicate that polyamine catabolism is a core metabolic response to stress.
A novel dominant selectable system for the selection of transgenic plants under in vitro and greenhouse conditions based on phosphite metabolism
Authors: López‐Arredondo Damar L. , Herrera‐Estrella Luis 
Published: March 2013

SummaryAntibiotic and herbicide resistance genes are currently the most frequently used selectable marker genes for plant research and crop development. However, the use of antibiotics and herbicides must be carefully controlled because the degree of susceptibility to these compounds varies widely among plant species and because they can also affect plant regeneration. Therefore, new selectable marker systems that are effective for a broad range of plant species are still needed. Here, we report a simple and inexpensive system based on providing transgenic plant cells the capacity to convert a nonmetabolizable compound (phosphite, Phi) into an essential nutrient for cell growth (phosphate) trough the expression of a bacterial gene encoding a phosphite oxidoreductase (PTXD). This system is effective for the selection of Arabidopsis transgenic plants by germinating T0 seeds directly on media supplemented with Phi and to select transgenic tobacco shoots from cocultivated leaf disc explants using nutrient media supplemented with Phi as both a source of phosphorus and selective agent. Because the ptxD/Phi system also allows the establishment of large‐scale screening systems under greenhouse conditions completely eliminating false transformation events, it should facilitate the development of novel plant transformation methods.
XXIInd International Congress of Photogrammetry and Remote Sensing
Authors: Newby Paul R. T. , Buckley Simon J. , Dowman Ian J. , Drummond Jane E. , Holland David A. , Lavender Samantha J. , Miller Pauline E. , Muller Jan‐Peter , Pfeifer Norbert , Polidori Laurent , Rekha Bhanu , Sima Aleksandra A. , Zielinski Rafal T. 
Published: March 2013

AbstractThe XXIInd International Congress of Photogrammetry and Remote Sensing was held at the Melbourne Convention and Exhibition Centre, Victoria, Australia, from 25th August to 1st September 2012. Reports are given on the Congress as a whole, including the General Assembly, Plenary and Special sessions, some Technical Commission activities and the Congress Exhibition. Papers from the Congress are published in Volume XXXIX of the International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences and Volume I of the new ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences.
Ecological restoration of reclaimed wastewater lakes using submerged plants and zooplankton
Authors: Li Kejun , He Wenhui , Hu Qian , Gao Song 
Published: March 2013

AbstractHigh‐pollutant concentrations have led to the breakout of planktonic bloom and the breakdown of the ecosystem in many lakes in China and other countries. The removal of the organic and inorganic pollutants from industrial, agricultural and domestic wastewater and the restoration of the aquatic ecosystem of the polluted water bodies are persistent issues. Constructed wetlands are often used, and most depend on emerged plants. In this study, Daphnia magna, a type of zooplankton, and five species of submerged plants were used to remove nitrogen and phosphorus from reclaimed domestic wastewater in four scenery lakes of a garden in Peking, China. Water quality was assessed by the local environmental inspection station as the government inspection and a commercial company as the third party inspection, and the gathered data proved that ecological restoration was successful in this study.
Investigating hydrologic alterations for wetland systems in terms of river environmental flows
Authors: Gül Ali , Onuşluel Gül Gülay , Dikmen A. Çağatay , Kuzucu Ayşegül 
Published: March 2013

AbstractTurkey's wetlands that represent a very diverse set of ecosystems are subject to considerable risks of biodiversity loss arising from the changes in their hydrology. Maintaining the full spectrum of naturally occurring flows in many rivers is almost impossible inTurkey's economically competing watersheds. Environmental flow assessments may still represent a compromise between water resources development and river ecology maintenance. In the presented study, changes in the water regimes observed in the period 1960–2000 are investigated together with concurrent ecological conditions for over 35 wetlands belonging to different ecological regions. The results, which are presented with indicator‐based risk figures to potentially correlate biodiversity loss to decreases in environmental flows in course of time, broadly indicate that substantial risks are estimated inTurkey in terms of environmental flows for wetland systems. Few exceptions appear in the north‐east in accordance with the recent climate change predictions indicating precipitation increase trends in the region.
To evaluate the effect of combining photo-activation therapy with platelet-rich plasma injections for the novel treatment of osteoarthritis
Authors: Freitag Julien Ben , Barnard Adele 
Published: March 2013

ObjectiveTo evaluate the effect of combining photo-activation therapy with platelet-rich plasma injections for the novel treatment of osteoarthritis.DesignWe present a case report of osteoarthritis of the knee treated with photo-activated platelet-rich plasma injections (PAPRP).MethodsAfter utilising conventional osteoarthritis treatment methods a patient underwent a course of PAPRP injections. The patient outcome was measured using the numerical pain rating scale (NPRS) and the Western Ontario and McMaster Universities Arthritis (WOMAC) Index.ResultsFollowing treatment the patient reported improvements in both pain and function as measured by the NPRS and WOMAC Index, respectively. The patient was followed up for 18 weeks, at which time no significant complications were noted.ConclusionsIn this case report of osteoarthritis, with strict control of conventional therapy variables, PAPRP injections demonstrated improvement in all recorded outcome measures. The results of this case report highlight the need to further investigate the use of PAPRP in the treatment of symptomatic knee osteoarthritis.
Molecular determinations ofEGFRandEML4-ALKon a single slide of NSCLC tissue
Authors: Ulivi Paola , Puccetti Maurizio , Capelli Laura , Chiadini Elisa , Bravaccini Sara , Calistri Daniele , Zoli Wainer , Amadori Dino , Candoli Piero 
Published: March 2013

IntroductionTyrosine kinase inhibitors (TKIs) and anti-anaplastic lymphoma kinase (ALK) agents are highly effective for the treatment of non-small cell lung cancer (NSCLC) patients harbouring specific alterations, and molecular characterisation of the tumour is needed even when limited tumour material is available.Methods20 patients with a known epidermal growth factor receptor (EGFR) gene status were enrolled: 10 had mutated and 10 had wild type tumours. FISH analysis was performed on one cytological or histological sample to determineEML4-ALKstatus, after which the same cells scraped off each slide were used to evaluate theEGFRstatus.ResultsIn the 10 EGFR mutated patients, molecular analysis showed the same results as those obtained before the FISH test. One patient with anEGFRmutation also showed anEML4-ALKtranslocation, and both FISH-positive and FISH-negative cells maintained theEGFRmutation.ConclusionsEGFRmutation analysis can be performed on the same sample previously submitted to theEML4-ALKFISH procedure.
The Impact of an Algorithm-Guided Management of Preoperative Anemia in Perioperative Hemoglobin Level and Transfusion of Major Orthopedic Surgery Patients
Authors: Enko Dietmar , Wallner Franz , von-Goedecke Achim , Hirschmugl Christa , Auersperg Vinzenz , Halwachs-Baumann Gabriele 
Published: March 2013

The aim of this study was to evaluate a laboratory-guided therapeutic algorithm of preoperative anemia. 335 patients with elective hip or knee arthroplasty were included in this retrospective before-after study. Group I (n= 101) underwent conventional preoperative procedures before algorithm implementation. Group II (n= 234) underwent algorithm-guided preoperative anemia management. A hemoglobin-level of 13 g/dL was the therapeutic cut-off for men and women. Reticulocyte hemoglobin content (CHr) and soluble transferrin receptor (sTfR)/log ferritin ratio were used in the form of the Thomas plot. Iron deficiency (ID) was substituted with 1000 mg iron intravenous (i.v.) and 10000 international units (I.U.) of erythropoiesis-stimulating agent (ESA) subcutaneous (s.c.) or i.v., anemia of chronic disease (ACD) (without functional ID) with 40000 I.U. ESA s.c. or i.v and additionally 200 mg iron i.v. Substituted anemic patients in Group II (n=32) showed a distinctly higher preoperative (Hb-median 13 versus 11.95 g/dL) (P<0.01) and postoperative (Hb-median 9.75 versus 9.0 g/dL) (P<0.05) Hb level compared with untreated anemic patients in Group I (n=24). In Group II red blood cell (RBC) units (35 units/234 patients) were reduced by 44% compared with Group I (27 units/101 patients). Algorithm-guided preoperative anemia management raises perioperative Hb-level and reduces blood use.
Serial Diffusion MRI to Monitor and Model Treatment Response of the Targeted Nanotherapy CRLX101
Authors: Ng Thomas S.C. , Wert David , Sohi Hargun , Procissi Daniel , Colcher David , Raubitschek Andrew A. , Jacobs Russell E. 
Published: March 2013

Abstract
Purpose: Targeted nanotherapies are being developed to improve tumor drug delivery and enhance therapeutic response. Techniques that can predict response will facilitate clinical translation and may help define optimal treatment strategies. We evaluated the efficacy of diffusion-weighted magnetic resonance imaging to monitor early response to CRLX101 (a cyclodextrin-based polymer particle containing the DNA topoisomerase I inhibitor camptothecin) nanotherapy (formerly IT-101), and explored its potential as a therapeutic response predictor using a mechanistic model of tumor cell proliferation.
Experimental Design: Diffusion MRI was serially conducted following CRLX101 administration in a mouse lymphoma model. Apparent diffusion coefficients (ADCs) extracted from the data were used as treatment response biomarkers. Animals treated with irinotecan (CPT-11) and saline were imaged for comparison. ADC data were also input into a mathematical model of tumor growth. Histological analysis using cleaved-caspase 3, terminal deoxynucleotidyl transferase–mediated dUTP nick end labeling, Ki-67, and hematoxylin and eosin (H&E) were conducted on tumor samples for correlation with imaging results.
Results: CRLX101-treated tumors at day 2, 4, and 7 posttreatment exhibited changes in mean ADC = 16 ± 9%, 24 ± 10%, 49 ± 17%, and size (TV) = −5 ± 3%, −30 ± 4%, and −45 ± 13%, respectively. Both parameters were statistically greater than controls [p(ADC) ≤ 0.02, and p(TV) ≤ 0.01 at day 4 and 7], and noticeably greater than CPT-11–treated tumors (ADC = 5 ± 5%, 14 ± 7%, and 18 ± 6%; TV = −15 ± 5%, −22 ± 13%, and −26 ± 8%). Model-derived parameters for cell proliferation obtained using ADC data distinguished CRLX101-treated tumors from controls (P = 0.02).
Conclusions: Temporal changes in ADC specified early CRLX101 treatment response and could be used to model image-derived cell proliferation rates following treatment. Comparisons of targeted and nontargeted treatments highlight the utility of noninvasive imaging and modeling to evaluate, monitor, and predict responses to targeted nanotherapeutics. Clin Cancer Res; 19(9); 2518–27. ©2013 AACR.
Tissue Redox Activity as a Hallmark of Carcinogenesis: From Early to Terminal Stages of Cancer
Authors: Bakalova Rumiana , Zhelev Zhivko , Aoki Ichio , Saga Tsuneo 
Published: March 2013

Abstract
Purpose: The study aimed to clarify the dynamics of tissue redox activity (TRA) in cancer progression and assess the importance of this parameter for therapeutic strategies.
Experimental Design: The experiments were carried out on brain tissues of neuroblastoma-bearing, glioma-bearing, and healthy mice. TRA was visualized in vivo by nitroxide-enhanced MRI on anesthetized animals or in vitro by electron paramagnetic resonance spectroscopy on isolated tissue specimens. Two biochemical parameters were analyzed in parallel: tissue total antioxidant capacity (TTAC) and plasma levels of matrix metalloproteinases (MMP).
Results: In the early stage of cancer, the brain tissues were characterized by a shorter-lived MRI signal than that from healthy brains (indicating a higher reducing activity for the nitroxide radical), which was accompanied by an enhancement of TTAC and MMP9 plasma levels. In the terminal stage of cancer, tissues in both hemispheres were characterized by a longer-lived MRI signal than in healthy brains (indicating a high-oxidative activity) that was accompanied by a decrease in TTAC and an increase in the MMP2/MMP9 plasma levels. Cancer progression also affected the redox potential of tissues distant from the primary tumor locus (liver and lung). Their oxidative status increased in both stages of cancer.
Conclusions: The study shows that tissue redox balance is very sensitive to the progression of cancer and can be used as a diagnostic marker of carcinogenesis. The study also suggests that the noncancerous tissues of a cancer-bearing organism are susceptible to oxidative damage and should be considered a therapeutic target. Clin Cancer Res; 19(9); 2503–17. ©2013 AACR.
Impact of Environmental Sensitivity on Occupational Performance
Authors: Peachey-Hill Carol , Law Mary 
Published: March 2013

Environmental sensitivity is a multi-system disorder characterized by adverse reactions to certain foods, chemicals, and environmental agents. In this study, the impact of environmental sensitivity on the person, environment, and occupation, as well as on occupational performance and time use, was determined. Using qualitative methods, 12 participants with environmental sensitivity were interviewed during a 2-month period. A time-use diary of activities over a 24hour period was obtained and compared with a survey conducted by Statistics Canada. Textual analysis was conducted by examining and coding data for emerging themes. Finally, the data were interpreted using the Person-Environment-Occupation Model (Law et al., 1996). Findings suggest a multiple-system involvement that leads to changes in type, time, and location of self-care, productive, and leisure occupations. Changes to personal health, environment, and occupations contributed to a decline in occupational performance. Enabling and constraining factors influenced the adaptation to changes in occupational performance. Emerging themes included an initial struggle for legitimacy, societal stigma, isolation, financial strain, and loss of personal expression. Management of environmental sensitivity involved making personal, environmental, and occupational changes. Possible roles for occupational therapists encompass issues of pacing, energy conservation, environmental changes, job modification, and matching occupational interests with personal abilities.
Validity of predischarge measures for predicting time to harm in older adults
Authors: Douglas Alison M. , Letts Lori J. , Richardson Julie A. , Eva Kevin W. 
Published: March 2013

Background. Concern is often expressed about the ability of persons with cognitive impairment to manage safely after discharge home from hospital. Measures validated for predicting safety are required. Purpose. The purpose of this study was to determine whether two predischarge functional measures were valid for predicting time to incident of harm after discharge. Method. Participants ( n = 47) were recruited from an inpatient rehabilitation unit. The Assessment of Motor and Process Skills (AMPS) and Cognitive Performance Test (CPT) were administered in hospital. Incident-of-harm outcome was measured by caregiver telephone questionnaire monthly for 6 months. Findings. Compared with all independent variables, AMPS Process scale was the best single predictor of time to incident of harm ( p = .01). CPT had a high specificity (91%) for identifying persons who did not have harm. Implications. Both AMPS and CPT demonstrated predictive validity for harm outcome over less predictive variables, such as comorbidities and activities-of-daily-living burden of care.
Le Retour Des Symboles Dans Un Cas De Readmission
Authors: Eevai Marie 
Published: March 2013

The symbols are a means to express the patient's conflicts. In a psychotic stage they are able to reach a depth where normally only artists can get. But while the artist explores voluntarily those deep feelings, the patient is forced by his illness to plunge into his unconscious, tortured all the time that he might not be able to find his way back to reality. We tried to demonstrate how the conflicts of a patient can be expressed by symbols. During this process the patient's personal symbols, related to his own individual case, get a plastic expression. If after many years the conflict is still not solved, it can evoke the same symbols expressed through a series of new pictures. The symbols used by the patients may be found in the plastic art of different civilizations. Thus we can conclude that the personal symbols are related to the archetypes of the collective unconscious.
Rood-based Program for Decreasing Pre-feeding Behaviours
Authors: Loiselle Cécile 
Published: March 2013

This article presents a review and organization of Margaret S. Rood's principles of neurophysiological intervention as related to the pre-feeding behaviours of tongue thrust, drooling, and gag reflex hypersensitivity in cerebral palsied children. General principles discussed include: functional divisions of the nervous system, combined effects of the primitive reflexes, and developmental sequence patterns. Treatment aims for the pre-feeding behaviours are derived from their neurophysiological pathology as described in the literature. The author attempts to interpret the limited and confusing literature on the subject and uses it as a base in choosing sensory and proprioceptive techniques to meet the outlined treatment aims. A follow-up article by this author describes a study which evaluated the treatment program detailed here. (Part II)
Trends in Lower Limb Splinting by Canadian Occupational and Physical Therapists
Authors: McKee Patricia R. , Brintnell E. Sharon 
Published: March 2013

This article highlights the results of a survey which examined the distribution of lower limb splinting practices in selected occupational and physical therapy departments located in the same hospital, in January, 1977. The responses yielded information on 72 (84%) of the 86 hospitals surveyed. The compiled data, therefore, provided a good indication of the distribution of the splinting practices for the two groups in question and represented a comprehensive collection of lower extremity splinting techniques by these professions. The survey indicated that: Both the occupational and physical therapy departments were involved in lower limb splinting; the former group, however, was more than twice as active as the latter. Occupational therapists were using low temperature thermoplastics almost exclusively, whereas physical therapists preferred plaster of paris. Many new techniques have been developed but few have been documented in occupational and physical therapy journals. The implications of the study are that occupational therapists should make a greater effort to share current and newly-developed techniques through publications and should strive to maximize the quality and performance of their splints.