bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Measurements and Clinical Outcomes After Wavefront-Guided LASEK Between iDesign and WaveScan
Authors: Jung Ji Won , Chung Byung Hoon , Han Sun Hyup , Kim Eung Kweon , Seo Kyoung Yul , Kim Tae-im 
Published: June 2015

PURPOSE:
To compare the measurements of refractive errors and ocular aberrations obtained using iDesign and WaveScan (Abbott Medical Optics, Inc., Santa Ana, CA), and to compare surgical outcomes of wavefront-guided LASEK using ablation profiles based on both aberrometers.

METHODS:
Ninety myopic eyes of 45 normal patients were evaluated using both the iDesign and WaveScan to measure spherical and cylindrical errors, spherical equivalents, and Zernike coefficients of ocular aberrations. Wavefront-guided LASEK was performed in a different group of 59 eyes of 30 patients divided into two groups, the iDesign and Wavescan groups. The clinical outcomes between the two groups including uncorrected visual acuity, refractive errors, contrast sensitivity, and ocular aberration were compared at 1, 3, and 6 months postoperatively.

RESULTS:
The iDesign produced significantly higher myopic values for refractive errors than the WaveScan, as well as significantly lower levels of total higher order, third, fourth, and fifth order root mean square values and Zernike coefficients of vertical coma and spherical aberration. At postoperative 1, 3, and 6 months, there were no statistically significant differences between the two groups in terms of uncorrected visual acuity and remaining refractive errors. The percentages of patients with spherical equivalents within ±1.00 and ±0.50 diopters of emmetropia were 100% (29 eyes) and 75.9% (22 eyes), respectively, in the iDesign group and 96.7% (29 eyes) and 70.0% (21 eyes), respectively, in the WaveScan group. Mesopic contrast sensitivity values were significantly higher, and the change in root mean square values for spherical aberration was significantly lower in the iDesign group.

CONCLUSIONS:
There were significant differences between the iDesign and the WaveScan in the measurements of refraction and ocular aberrations. Wavefront-guided LASEK based on an ablation profile from the iDesign demonstrated comparable refractive predictability with the WaveScan group, resulting in minimal physician adjustment and superior postoperative visual quality.

[
J Refract Surg.
2015;31(6):398–405.]
Wavefront-Guided Laser Treatment Using a High-Resolution Aberrometer to Measure Irregular Corneas: A Pilot Study
Authors: Shaheen Mohamed Shafik , El-Kateb Mohamed , Hafez Tarek A. , Piñero David P. , Khalifa Mounir A. 
Published: June 2015

PURPOSE:
To evaluate in a pilot study the visual, refractive, corneal topographic, and aberrometric changes after wavefront-guided LASIK or photorefractive keratectomy (PRK) using a high-resolution aberrometer to calculate the treatment for aberrated eyes.

METHODS:
Twenty aberrated eyes of 18 patients undergoing wavefront-guided LASIK or PRK using the VISX STARS4IR excimer laser and the iDesign aberrometer (Abbott Medical Optics, Inc., Santa Ana, CA) were enrolled in this prospective study. Three groups were differentiated: keratoconus post-CXL group including 11 keratoconic eyes (10 patients), post-LASIK group including 5 eyes (5 patients) with previous decentered LASIK treatments, and post-RK group including 4 eyes (3 patients) with previous radial keratotomy. Visual, refractive, contrast sensitivity, corneal topographic, and ocular aberrometric changes were evaluated during a 6-month follow-up.

RESULTS:

An improvement in uncorrected (UDVA) and corrected visual acuity (CDVA) associated with a reduction in the spherical equivalent was observed in the three groups, but was only statistically significant in the keratoconus post-CXL and post-LASIK groups (
P
≤ .04). All eyes gained one or more lines of CDVA after surgery. Improvements in contrast sensitivity were observed in the three groups, but they were only statistically significant in the keratoconus post-CXL and post-LASIK groups (
P
≤ .04). Regarding aberrations, a reduction was observed in trefoil aberrations in the keratoconus post-CXL group (
P
= .05) and significant reductions in higher-order and primary coma aberrations in the post-LASIK group (
P
= .04).

CONCLUSIONS:
Wavefront-guided laser enhancements using the evaluated platform seem to be safe and effective to restore the visual function in aberrated eyes.

[
J Refract Surg.
2015;31(6):411–418.]
Accelerated Corneal Collagen Cross-Linking in Thin Keratoconic Corneas
Authors: Ozgurhan Engin Bilge , Akcay Betul Ilkay Sezgin , Kurt Tugba , Yildirim Yusuf , Demirok Ahmet 
Published: June 2015

PURPOSE:

To report the outcomes of accelerated corneal collagen cross-linking in patients with thin corneas (minimum corneal thickness < 400
µ
m).

METHODS:

Thirty-four eyes of 34 patients with a minimum corneal thickness less than 400
µ
m were included. All patients underwent accelerated corneal collagen cross-linking (irradiance power of 30 mW/cm
2
at 3 minutes with a total surface dose of 5.4 J/cm
2
). Uncorrected (UDVA) and corrected distance visual acuity (CDVA), manifest refraction (diopters [D]), and topography were evaluated at baseline and at the 1-, 6-, and 12-month follow-up visit. Endothelial cell density (cells/mm
2
) was calculated preoperatively and postoperatively at 12 months. The corneal stromal demarcation line was measured using anterior segment optical coherence tomography at 1 month postoperatively.

RESULTS:

The mean age of all patients (14 women and 20 men) was 23.08 ± 3.90 years (range: 16 to 29 years). UDVA and CDVA increased but not significantly. UDVA improved from 0.67 ± 0.32 (20/93 ± 20/41 Snellen) to 0.56 ± 0.28 logMAR (20/72 ± 20/38 Snellen) (
P
= .033) and CDVA improved from 0.49 ± 0.19 (20/61 ± 20/30 Snellen) to 0.42 ± 0.19 logMAR (20/52 ± 20/30 Snellen) (
P
= .009) at the last follow-up visit. The mean spherical and cylindrical refractions did not significantly change (
P
= .100 and 0.139, respectively). At the last follow-up visit, the flat keratometry decreased from 47.40 ± 2.52 to 46.95 ± 2.48 D, steep keratometry decreased from 51.04 ± 3.71 to 50.62 ± 3.57 D, and apex keratometry decreased from 57.58 ± 4.49 to 56.26 ± 4.47 D (
P
= .001, = .0019, = .001, respectively) from baseline. The mean endothelial cell density changed from 2,726.02 ± 230.21 to 2,714.58 ± 218.26 cells/mm
2
at 12 months postoperatively (
P
=.086).

CONCLUSION:
The results of this study revealed that accelerated corneal collagen cross-linking stabilized the progression of keratoconus without a significant endothelial cell density loss during the 12 months of follow-up.

[
J Refract Surg.
2015;31(6):386–390.]
Actitudes docentes y buenas prácticas con TIC del profesorado de Educación Permanente de Adultos en AndalucíaActitudes docentes y buenas prácticas con TIC del profesorado de Educación Permanente de Adultos en Andalucía
Authors: Fernández Batanero Jose María , Torres González José Antonio 
Published: June 2015

El presente artículo recoge los resultados de un estudio cuyo objetivo ha sido determinar las actitudes del profesorado de educación permanente de adultos de la comunidad autónoma de Andalucía, hacia el uso e integración de las Tecnologías de la Información y Comunicación (TIC) en sus respectivos centros, al mismo tiempo que identificar aquellos factores que favorecen el desarrollo de buenas prácticas. El diseño de investigación es de tipo descriptivo mixto. Las técnicas utilizadas para la recogida de información han sido el cuestionario y la entrevista en profundidad. Se realizaron 172 encuestas a profesores y profesoras, así como 18 entrevistas a directores y coordinadores de Sección de Adultos. Para la validación del cuestionario, se utilizó la técnica de juicio de expertos, seleccionados mediante el procedimiento de «Coeficiente de competencia experta» o «Coeficiente K». Para fortalecer las propiedades psicométricas se determinó la validez de constructo mediante un análisis factorial con el método Varimax y extracción de máxima verosimilitud, donde se extrajeron dos factores. La confiablidad se estableció mediante el Alfa de Cronbach (0.88). La guía de entrevista fue validada por el mismo grupo de expertos. Los resultados señalan por un lado, que los docentes poseen actitudes positivas hacia las TIC tanto en lo relativo a su papel en desarrollo profesional, como en cuanto a la facilidad y accesibilidad de estas. Por otro, entre los factores más importantes para proporcionar buenas prácticas educativas con apoyo de TIC se encuentra la capacidad de estas para favorecer el trabajo personalizado.
Evaluación de necesidades y expectativas ante la construcción de un espacio interactivo de comunicación, información y aprendizaje histórico-educativo
Authors: Mengual-Andrés Santiago , Payá Rico Andrés , Roig Vila Rosabel 
Published: June 2015

Conscientes de las posibilidades pedagógicas, participativas y de colaboración científica de la Web 2.0, los autores del presente artículo se plantean la detección de las necesidades y expectativas hacia la creación de una plataforma virtual delimitada por un espacio interactivo o red social para la Historia de la Educación y el Patrimonio Histórico-educativo. Gracias a la evaluación mediante un cuestionario en el que han participado un grupo de expertos docentes e investigadores de Historia de la Educación, se han obtenido una serie de conclusiones a tener en cuenta respecto a determinados aspectos (conocimiento y uso, expectativas, componentes, etc.) que orientarán la construcción ad hoc de dicha plataforma. Es relevante el poco conocimiento y uso de las redes sociales tanto genéricas como específicas, así como otro tipo de aplicaciones web. Destaca, por otro lado, que la edad de los participantes no ha condicionado la importancia percibida sobre las capacidades de las TIC para el desarrollo en la docencia y la investigación.
ANALYSIS OF AUTOHESION AND PHYSICO-MECHANICAL PROPERTIES (MULTIFUNCTIONAL BEHAVIOR) OF THE COAGULUM FROM THE LATEX OF EUPHORBIA CADUCIFOLIA HAINES VIS-À-VIS COMPARISON AGAINST SYNTHETIC RESINS IN NATURAL RUBBER COMPOUNDS
Authors: Bhattacharyya Sanjay K. , Parmar Bhavani S. , Mukhopadhyay Rabindra , Bandyopadhyay Abhijit 
Published: June 2015

ABSTRACT
Soft and tacky mass recognized as whole coagulum (Cog) and its toluene soluble fraction (TE) obtained through coagulation of latex of Euphorbia caducifolia Haines has been investigated in this article as green tackifier cum multifunctional agent in natural rubber (NR) based gum compounds. It was observed that inclusion of TE and Cog in the formulations increased tack strength over the control compound (without TE and Cog). At the same loading, autohesion for natural and commercial coumarone indene resin was found comparable. However, phenol formaldehyde (non–heat reactive octyl phenol formaldehyde) resin demonstrated highest tack strength among all the NR compositions studied. Presence of various functional groups such as esters/carboxylic acid, carbon–carbon unsaturation, and so on, in natural resin activated the system and reduced the activation energy barrier for curing. The optimized composition with 5 phr TE showed nearly 5% reductions in activation energy over the control compound. However, no such cure acceleration was displayed by Cog. Unaged tensile properties of the compounds with natural resin at similar proportions to commercial resins were found comparable. Retention of tensile properties after aging for the vulcanizates with TE was better than those with the commercial resins. For Cog, however, the retention of elongation at break and tensile strength were slightly higher compared with tensile modulus.
Cyclodialysis-Enhanced Trabeculectomy with Triple Ologen Implantation
Authors: Dada Tanuj , Sharma Reetika , Sinha Gautam , Angmo Dewang , Temkar Shreyas 
Published: June 2015

Purpose To describe a novel technique of trabeculectomy combined with cyclodialysis and Ologen implantation at 3 sites in cases with high risk for failure of trabeculectomy. Methods Six eyes of 6 patients who had high risk for failure of trabeculectomy underwent cyclodialysis-augmented trabeculectomy with Ologen implantation at 3 sites using the described technique. Results All the eyes achieved target intraocular pressure, which was maintained until 1 year of follow-up. One eye required bleb needling at 6 weeks postoperative follow-up. None of the eyes had any other intraoperative or postoperative complications. Conclusions This novel technique of combining trabeculectomy with cyclodialysis augmented by Ologen placement at 3 locations appears to have encouraging short-term intraocular pressure control and may be adopted in eyes with risk factors for failure of conventional trabeculectomy.
A Novel Design of a Polymeric Aortic Valve
Authors: Gharaie Saleh Hassanzadeh , Morsi Yos 
Published: June 2015

Introduction In this paper we propose a novel method for developing a polymeric heart valve that could potentially offer an optimum solution for a heart valve substitute. The valve design proposed will provide superior hydrodynamic performance and excellent structural integrity. A full description of the design process is given together with an analysis of the hemodynamic performance using a 2-way strongly coupled Fluid Structure Interaction (FSI). Method A polymeric tri-leaflet heart valve is designed based on a patient's sinus of Valsalva (SOV) geometry. The design strategy aims to improve valve hemodynamic performance as well as valve durability by avoiding stress concentrations in the leaflets and reducing the maximum stress level. The valve dynamics and stress levels are also validated by comparing the predicted data to existing experimental and numerical data. Results The stress distribution in the valve structure is fully characterized throughout the simulation and Von Mises stress is found to be up to 5.32 Mpa during diastole. The results show that an effective orifice area (EOA) and a pressure drop of 3.22 cm^2, and 3.52 mmHg, respectively, can be achieved using the proposed design. Conclusions The optimized valve demonstrates high hemodynamic performance with no sign of damaging stress concentration in the entire cardiac cycle.
Human Plasma Protein Adsorption onto Alumina Nanoparticles Relevant to Orthopedic Wear
Authors: Gibbons John P. , Monopoli Marco P. , Lundqvist Martin , Montes-Burgos Iker , McGrath Eilis E. , Elia Giuliano , Lynch Iseult , Dawson Kenneth A. , Stanton Kenneth T. 
Published: June 2015

Purpose Wear of ceramic orthopedic devices generates nanoparticles in vivo that may present a different biological character from the monolithic ceramic from which they are formed. The current work investigated protein adsorption from human plasma on alumina nanoparticles and monolithic samples representative of both wear particles and the ceramic components as implanted. Materials and Methods A physicochemical characterization of the particles and their dispersion state was carried out, and the protein adsorption profiles were analyzed using 1D SDS-PAGE and mass spectrometry. Results Significant differences in protein-binding profiles were identified where the nanoparticles selectively bound known transporter proteins rather than the more highly abundant serum proteins that were observed on the monoliths. Conclusions Proteins associated with opsonization of particles were seen to be present in the protein corona of the nanoparticles, which raises questions regarding the role of wear particles in periprosthetic tissue inflammation and aseptic loosening.
Effect of 830-nm Laser Phototherapy on Olfactory Neuronal Ensheathing Cells Grown in Vitro on Novel Bioscaffolds
Authors: Renno Ana Claudia Muniz , McDonnell Pauline Ann , Camuri Crovace Murilo , Zanotto Edgar Dutra , Laakso E-Liisa 
Published: June 2015

Background The purpose of this study was to analyze olfactory ensheathing cell (OEC) proliferation and growth on Biosilicate and collagen bioscaffolds, and to determine whether the application of laser phototherapy would result in increased OEC proliferation on the scaffolds. The use of bioscaffolds is considered a promising strategy in a number of clinical applications where tissue healing is suboptimal. As in vitro OEC growth is a slow process, laser phototherapy could be useful to stimulate proliferation on bioscaffolds. Methods OEC cells were seeded on the Biosilicate and collagen scaffolds. Seeded scaffolds were irradiated with a single exposure of 830-nm laser. Nonirradiated seeded scaffolds acted as negative controls. Cell proliferation was assessed 7 days after irradiation. Results OECs were successfully grown on discs composed of a glass-ceramic and collagen composite. Laser irradiation produced a 32.7% decrease and a 13.2% increase in OEC proliferation on glass-ceramic discs and on collagen scaffolds, respectively, compared with controls. Laser phototherapy resulted in a reduction in cell growth on the Biosilicate scaffolds and an increase in cell proliferation on collagen scaffolds. Conclusions These results were probably due to the nature of the materials. Future research combining laser phototherapy and glass-ceramic scaffolds should take into account possible interactions of the laser with matrix compounds.
Impact of Preanalytical Factors on Fecal Immunochemical Tests: Need for New Strategies in Comparison of Methods
Authors: Rubeca Tiziana , Cellai Filippo , Confortini Massimo , Fraser Callum G. , Rapi Stefano 
Published: June 2015

Background Harmonization of fecal immunochemical tests for hemoglobin (FIT-Hb) is crucial to compare clinical outcomes in screening programs. The lack of reference materials and standard procedures does not allow the use of usual protocols to compare methods. We propose 2 protocols, based on artificial biological samples (ABS), to discriminate preanalytical and analytical variation and investigate clinical performances. The protocols were used to compare 2 FIT systems available on European markets: the OC-Sensor Diana (Eiken, Tokyo, Japan) and HM-JACKarc (Kyowa-Medex, Tokyo, Japan). Methods ABS were obtained adding Hb to Hb-free feces. In the first procedure, 35 ABS were collected for each collection device and analyzed on both systems. In the second, 188 ABS (106 positive and 82 negative) were ­collected and tested on the specific systems. Passing-Bablock (PB), Pearson's correlation coefficients (R) and Bland-Altman difference analysis were used to compare data. Results PB, R and mean standard errors for Bland-Altman analysis (Diana vs. Arc) results were 0.93x-0.56: R = 0.97 and 19%; and 1.09x + 5.60: R = 0.96 and −18%; for Diana and Arc devices, respectively. No correlations and no difference in positive/negative assessment were observed with the second protocol. Conclusions A good correlation was observed in comparing data generated using collection devices on the 2 systems. Manufacturers have developed different sample collection procedures for feces: therefore, data from different systems cannot easily be compared. Adoption of protocols to discriminate preanalytical and analytical variation would be a significant contribution to harmonization of FIT, facilitating data comparison and information acquisition for sample collection strategy and effect of buffers on systems.
Circulating Tumor Cells are Predictive of Poor Response to Chemotherapy in Metastatic gastric cancer
Authors: Lee Su Jin , Lee Jeeyun , Kim Seung Tae , Park Se Hoon , Park Joon Oh , Park Young Suk , Lim Ho Yeong , Kang Won Ki 
Published: June 2015

Background The aim of this study was to investigate the impact of number of circulating tumor cells (CTCs) on the treatment outcome for metastatic gastric cancer (GC) following palliative chemotherapy. Methods CTCs were isolated from 7.5 mL of whole blood from 100 patients with metastatic GC by anti-EpCAM antibody coated magnetic particles using the CTC-Profiler (Veridex). Correlations between CTC counts and clinicopathological variables, progression-free survival and overall survival were examined. Results Between January 2010 and August 2010, 100 metastatic GC patients were enlisted. Among 100 patients, 5 or more CTCs (CTC-positive) were detected in 27 of 95 patients (28%). Even though the clinical characteristics of the CTC-positive and CTC-negative groups were not significantly different, the treatment response to cytotoxic chemotherapy in the CTC-positive group was significantly poorer (progressive disease: 23.4% vs. 60.0% in CTC-negative vs. CTC-positive group, respectively; p = 0.004). The median progression-free survival of the CTC-positive group was substantially shorter than that of the CTC-negative group (59 days vs. 141 days; p = 0.004). For overall survival, CTC-positive group had significantly shorter survival than CTC-negative group (median OS, 120 days vs. 220 days; p = 0.030). A multivariate Cox proportional hazards regression model showed that CTC positivity was an independent adverse factor for progression-free survival and overall survival. Conclusions This study suggests CTCs are associated with poor response to chemotherapy in metastatic GC ­patients.
Endovascular Recanalization of a Port Catheter-associated Superior vena Cava Syndrome
Authors: Tonak Julia , Fetscher Sebastian , Barkhausen Jörg , Goltz Jan Peter 
Published: June 2015

Purpose Superior vena cava (SVC) syndrome owing to benign etiology is rare and endovascular techniques have been advocated as the treatment of choice. We report a case of endovascular revascularization of a port catheter-associated complete occlusion of the SVC with reversed flow in the azygos vein. Methods In this setting using a sheath in combination with its dilatator to pass the occlusion of the SVC after neither a diagnostic catheter nor a PTA balloon would pass the lesion may be a valid option. A dual venous approach was established using the right common femoral vein and an indwelling port catheter in the right cephalic vein to dilate and stent the lesion. Finally, a port may be implanted after the revascularization had been successful. Results Passage through the port catheter-associated occlusion of the SVC was only possible by use of the sheath in combination with its dilatator. A dual venous access by the femoral approach and the indwelling central catheter is helpful in treating a SVC occlusion. Conclusions Long-term central venous catheters may cause SVC syndrome, especially with a catheter tip located too far cranially. An endovascular revascularization of a complete occlusion of the SVC represents the therapy of choice.