bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term effect of air pollution exposure on COPD exacerbations: a time series study in Bogota, Colombia
Authors: López Astrid Berena Herrera , Torres-Duque Carlos A. , Arbeláez María Patricia , Roa Néstor Yezid Rojas , Riojas-Rodríguez Horacio , Sangrador José Luis Texcalac , Herrera Víctor , Rodríguez-Villamizar Laura Andrea 
Published: August 2024

Abstract
Introduction
Air pollution poses a risk for people with Chronic Obstructive Pulmonary Disease (COPD). This study estimated the short-term effect of variations in air pollutant concentrations on exacerbations of COPD (COPD-E) in Bogotá, Colombia.

Methods
We performed an ecological time series study from 2014 to 2021 to evaluate the short-term effect of fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) levels on COPD-E treated in the emergency and hospitalization services. Daily counts of patients with COPD-E discharge diagnoses were obtained from the National Health Information System, and daily measurements of PM2.5, NO2, and O3 concentrations and meteorological data were obtained from air monitoring stations. A Generalized Additive Model was used with Distributed Lag Non-Linear Models to control for confounders.

Results
An increase of 10 μg/m3 in PM2.5 and O3 was associated with increased COPD-E admissions (lagged 0-3 days) with Relative Risk (RR) of 1.04 (95%CI: 1.02 -1.07) and RR:1.03 (95%CI:1.01 – 1.04), respectively. During the rainy season and minimum temperature of the series, for every 10 μg/m3 increase in PM2.5 concentration, COPD-E admissions (lagged 0-3 days) increased with RR 1.03 (95%CI: 1.01-1.06). A higher magnitude of association was observed in men (PM2.5, 1.04 95%CI:1.01 – 1.06 and O3, 1.04 95%CI:1.02 – 1.05, lag 0-7 days) than in women.

Conclusions
A higher air pollution was associated with more COPD-E. These results highlight the importance of actions aimed at improving air quality.

Graphical Abstract
Malignant Recurrence of Benign Odontogenic Tumors (A Single Center Cross-Sectional Study)
Authors: Abdul-Aziz Manar Abdul-Waniss Mohammed , Rashad Asmaa Emad El-Din Mohammed , Saleh Heba Ahmed 
Published: August 2024

Abstract
Background
Despite their rarity, malignant odontogenic tumors (MOT) represent an important group of oral lesions characterized by their variable clinical presentations and sometimes unexpected biological behavior.

Objectives
The purpose of this retrospective cross-sectional study was to evaluate the number, types, and frequency of MOT and to investigate the relative rate of malignant transformation in recurrent odontogenic tumors (OT).

Methodology
The records of patients diagnosed with OT in the hospital of the Faculty of Dentistry, Cairo University, were reviewed over 10 years (2013-2022). The OT were investigated for frequency, age, gender, site, and recurrence. The data were recorded and then analyzed using SPSS software version 25.

Results
Among 5543 oral excisions, 357 cases of them were OT, including 336 benign (94.1%) and 21 malignant neoplasms (5.9%). Among the odontogenic malignancies, 18 lesions (85.7%) appeared de novo, and 3 lesions (14.3%) developed as recurrent of previously classified benign tumors. A high incidence was observed in the middle and old age groups (90.4%) with a median age being 42. Slight male predilection (1.3:1) was noticed. The mandible was the highly affected site but all recurrent cases were diagnosed in the maxilla as ghost cell odontogenic carcinoma (n = 2, 66.6%) and primary intraosseous carcinoma (n = 1, 33.3%).

Conclusion
Retrospective analysis of the relative frequency of MOT and the documentation of the unusual recurrence of benign OT as a malignancy enhances our understanding of OT behavior and the need for appropriate therapy and clinical follow-up.
Mindfulness and proactivity: friends or enemies? Latent profiles and relationships with task performance and creativity
Authors: Petrou Paraskevas , Xanthopoulou Despoina , Mäkikangas Anne 
Published: August 2024

AbstractIn line with control theory and related self-regulation perspectives as well as the dual pathway to creativity model, proactivity and mindfulness are both expected to enhance employee task performance and creativity. However, whether proactivity and mindfulness strengthen or undermine each other’s effects remains an open question. To address this question, we conducted a cross-sectional (Study 1; N = 255 employees) and a 4-week diary study (Study 2; N = 143 employees), and we adopted a latent profile analysis (LPA) approach with task performance and creativity as focal outcomes. Even though several employee profiles emerged from the datasets, two of them were replicated across both studies namely, the “proactive employees” (reporting high proactivity and low mindfulness) and the “proactive mindful employees” (reporting high proactivity and high mindfulness). Findings of both studies showed that the “proactive mindful employees” report the highest levels of creativity. The analyses of Study 2 furthermore revealed that both profiles display superior task performance compared to other profiles. The findings are discussed in light of the current debate in the literature, and recommendations for future research as well as for individual employees are provided (e.g., formulating mindful goals in a proactive way or proactive goals in a mindful way).
A lower initial dose of bosutinib for patients with chronic myeloid leukemia patients resistant and/or intolerant to prior therapy: a single-arm, multicenter, phase 2 trial (BOGI trial)
Authors: Ureshino Hiroshi , Takahashi Naoto , Ikezoe Takayuki , Kameoka Yoshihiro , Kimura Satoshi , Fukushima Noriyasu , Ichinohe Tatsuo , Takamori Ayako , Kawaguchi Atsushi , Miura Masatomo , Kimura Shinya 
Published: August 2024

AbstractAlthough bosutinib is generally safe and effective, drug-related toxicities (DRTs) such as diarrhea or increased transaminase levels often lead to treatment discontinuation. To clarify whether a lower initial dose of bosutinib (i.e., starting at 200 mg) would reduce rates of discontinuation due to DRTs, we conducted a phase 2 study of BOsutinib Gradual Increase (BOGI trial, UMIN 000032282) as a second/third-line treatment for chronic myeloid leukemia (CML). Between February 4, 2019 and May 24, 2022, 35 patients were enrolled. The rate of bosutinib discontinuation at 12 months was 25.7% vs. 35.9% in a historical control study (Japanese phase 1/2 study) (p = 0.102). The rate of bosutinib discontinuation due to DRTs was significantly lower, at 11.4% vs. 28.2% (p = 0.015). The incidence of grade 3/4 transaminase elevation was 20% vs. 29% (p = 0.427), while the incidence of diarrhea was 3% vs. 25% (p = 0.009). The median dose intensity of bosutinib was higher (391.7 mg/day vs. 353.9 mg/day). Pharmacokinetic analysis of bosutinib showed that patients who achieved a major molecular response tended to have high trough concentrations. Thus, a low initial dose of bosutinib followed by dose escalation reduced discontinuation due to severe DRTs while maintaining high dose intensity and efficacy.
Dynamic analysis of the fractional-order logistic equation with two different delays
Authors: El-Saka H. A. A. , El-Sherbeny D. El. A. , El-Sayed A. M. A. 
Published: August 2024

AbstractIn this paper, we analyze the stability and Hopf bifurcation of the fractional-order logistic equation with two different delays $$\tau _{1}, \tau _{2}>0$$

τ
1

,

τ
2

>
0

: $$D^{\alpha }y(t)=\rho y(t-\tau _{1})\left( 1-y(t-\tau _{2})\right) $$

D
α

y

(
t
)

=
ρ
y

(
t
-

τ
1

)

1
-
y
(
t
-

τ
2

)

, $$t>0$$

t
>
0

, $$\rho >0$$

ρ
>
0

. We describe stability regions by using critical curves. We explore how the fractional order $$\alpha $$
α
, $$\rho $$
ρ
, and time delays influence the stability and Hopf bifurcation of the model. Then, by choosing $$\rho $$
ρ
, fractional order $$\alpha $$
α
, and time delays as bifurcation parameters, the existence of Hopf bifurcation is studied. An Adams-type predictor–corrector method is extended to solve fractional-order differential equations involving two different delays. Finally, numerical simulations are given to illustrate the effectiveness and feasibility of theoretical results.
Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases
Authors: Bao Qingdong , Zhang Xiaoting , Hao Zhankun , Li Qinghua , Wu Fan , Wang Kaiyuan , Li Yang , Li Wenlong , Gao Hua 
Published: August 2024

AbstractThe eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as the blood-retinal barrier and corneal impermeability. Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance. Polysaccharide-based microneedles (PSMNs) have emerged as a transformative solution for ophthalmic drug delivery. However, a comprehensive review of PSMNs in ophthalmology has not been published to date. In this review, we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery. We provide a thorough analysis of PSMNs, summarizing the design principles, fabrication processes, and challenges addressed during fabrication, including improving patient comfort and compliance. We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios. Finally, we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.
Assessing Patterns and Trends in Urbanization and Land Use Efficiency Across the Philippines: A Comprehensive Analysis Using Global Earth Observation Data and SDG 11.3.1 Indicators
Authors: Santillan Jojene R. , Heipke Christian 
Published: August 2024

AbstractUrbanization, a global phenomenon with profound implications for sustainable development, is a focal point of Sustainable Development Goal 11 (SDG 11). Aimed at fostering inclusive, resilient, and sustainable urbanization by 2030, SDG 11 emphasizes the importance of monitoring land use efficiency (LUE) through indicator 11.3.1. In the Philippines, urbanization has surged over recent decades. Despite its importance, research on urbanization and LUE has predominantly focused on the country’s national capital region (Metro Manila), while little to no attention is given to comprehensive investigations across different regions, provinces, cities, and municipalities of the country. Additionally, challenges in acquiring consistent spatial data, especially due to the Philippines’ archipelagic nature, have hindered comprehensive analysis. To address these gaps, this study conducts a thorough examination of urbanization patterns and LUE dynamics in the Philippines from 1975 to 2020, leveraging Global Human Settlement Layers (GHSL) data and secondary indicators associated with SDG 11.3.1. Our study examines spatial patterns and temporal trends in built-up area expansion, population growth, and LUE characteristics at both city and municipal levels. Among the major findings are the substantial growth in built-up areas and population across the country. We also found a shift in urban growth dynamics, with Metro Manila showing limited expansion in recent years while new urban growth emerges in other regions of the country. Our analysis of the spatiotemporal patterns of Land Consumption Rate (LCR) revealed three distinct evolutional phases: a growth phase between 1975–1990, followed by a decline phase between 1990–2005, and a resurgence phase from 2005–2020. Generally declining trends in LCR and Population Growth Rate (PGR) were evident, demonstrating the country’s direction towards efficient built-up land utilization. However, this efficiency coincides with overcrowding issues as revealed by additional indicators such as the Abstract Achieved Population Density in Expansion Areas (AAPDEA) and Marginal Land Consumption per New Inhabitant (MLCNI). We also analyzed the spatial patterns and temporal trends of LUE across the country and found distinct clusters of transitioning urban centers, densely inhabited metropolises, expanding metropolitan regions, and rapidly growing urban hubs. The study’s findings suggest the need for policy interventions that promote compact and sustainable urban development, equitable regional development, and measures to address overcrowding in urban areas. By aligning policies with the observed spatial and temporal trends, decision-makers can work towards achieving SDG 11, fostering inclusive, resilient, and sustainable urbanization in the Philippines.
Progress of Main-Group Metal-Based Single-Atom Catalysts
Authors: Wang Tongzhou , Sun Yuhan , Fu Genyuan , Jiang Zhiqi , Zheng Xuerong , Li Jihong , Deng Yida 
Published: August 2024

AbstractSingle-atom catalysts (SACs) have emerged as promising materials in energy conversion and storage systems due to their maximal atom utilization, unique electronic structure, and high efficiency. Among them, main-group metal-based SACs (the s-block and p-block metals) are emerging extraordinary materials and have attracted particular interest in the past few years but are still confronted with several challenges. Initiating with a critical overview of the fundamentals and unique advantages associated with main-group metals, the review proceeds to highlight several types of main-group metal-based SACs. These include s-block metals such as Mg and Ca, and p-block metals such as In, Bi, Al, Ga, Sb, Se, and Sn. The applications of these SACs in diverse chemical energy conversion processes are thoroughly explored. Finally, to promote the future development of highly efficient main-group metal SACs, the critical challenges and prospects in this emerging field are proposed. This review presents a fresh impetus and solid platform for the rational design and synthesis of high-performance main-group metal SAC catalysts for chemical energy conversion fields.
Graphical Abstract
Main-group metal-based SACs are emerging extraordinary materials and have attracted particular interest in the past few years. In this review, several types of main-group metal SACs and their applications in energy storage and conversion are summarized, with the emphasis on the correlation between catalytic activities and geometric structures to guide the construction of novel main-group metal SACs with unrivaled performance
The status of rural children left-behind in China: 2010–2020
Authors: Lyu Lidan , Mei Ziying , Yan Fang , Wang Xu , Duan Chengrong 
Published: August 2024

AbstractThis paper uses the 2010 and 2020 Population Census micro-data to analyze relevant characteristics and trends over the decade. The analysis includes the following aspects: population size of rural children left-behind, their age structure and sex composition, regional distribution, living arrangements, and educational development. The findings show that the population size of rural children left-behind remained large, and the likelihood of children being left-behind was closely related to age, with no significant difference by sex. An increasing proportion of rural children left-behind were cared for by grandparents as more mothers migrated between 2010 and 2020. Rural children left-behind no longer had an advantage in educational opportunities compared with average rural children. Over-age attendance was more prevalent among rural children left-behind than all rural children. Continuous attention should be paid to the issue of rural children left-behind and efforts should be made to address its root causes.
Früh auf braunem Kurs: Die Zeitschrift „Der Landarzt“ zwischen 1933 und 1944
Authors: Bruns Florian , Rauh Philipp 
Published: August 2024

ZusammenfassungDie 1919 gegründete Zeitschrift „Der Landarzt“ ist die Vorgängerin der heutigen „Zeitschrift für Allgemeinmedizin“. Von 1933 bis 1936 trug der „Landarzt“ vorübergehend den Titel „Zentralblatt für Landärzte“. Neben medizinischen Inhalten adressierte das Journal traditionell berufspolitische und alltagspraktische Themen für Landärzte. Bereits 1929 erschienen im „Landarzt“ Artikel zur „Rassenhygiene“, sodass die nationalsozialistische Machtübernahme 1933 in dieser Hinsicht keine besondere Zäsur darstellte. Seit 1937 erschien die Zeitschrift im Stuttgarter Hippokrates-Verlag. In der Folge verstärkte sich die schon vorher bestehende Tendenz zur Naturheilkunde und Homöopathie, was zur Ausrichtung der nationalsozialistischen Gesundheitspolitik in jener Zeit passte. Hoffnungen auf eine nachhaltige Unterstützung der Landärzte durch die Nationalsozialisten erfüllten sich nur teilweise und waren spätestens im Zweiten Weltkrieg obsolet. Im Herbst 1944 musste der „Landarzt“ sein Erscheinen kriegsbedingt einstellen.
How to trigger employee proactive behavior? Introducing the ritual perspective
Authors: Ni Dan , Lu Hailing , Wang Yongli 
Published: August 2024

Abstract
Much research on the antecedents of proactive behavior has appeared in the literature, but this research introduces a new ritual perspective to rethink this question. Drawing on the process model of interaction rituals, we propose that work rituals urge employees to share emotional energy, and then, employees are likely to experience a higher level of work meaningfulness. In turn, employees tend to engage in more proactive behavior. Using data from a random assignment field experiment involving 204 employees from a communication corporation in China, we found support for our hypotheses. The implications of our research for theory and practice are discussed.
Spiritual care interventions for palliative care patients: A scoping review
Authors: Jaman-Mewes Paula , Caetano da Silva de Oliveira Mayara , Regina Mazotti Marcia , Salvetti Marina de Goés 
Published: August 2024

AbstractObjectivesTo identify and map spiritual care interventions to address spiritual needs and alleviate suffering of patients in the context of palliative care.MethodsA scoping review using the PRISMA ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) checklist was conducted according to the JBI (Joanna Briggs Institute) guidelines. The search was conducted from October 2022 to January 2023 using 9 electronic databases and gray literature. Studies on spiritual care interventions in palliative care were included. Disagreements between the 2 reviewers were resolved by discussion or a third reviewer.ResultsA total of 47 studies were included in this review. All selected articles were published between 2003 and 2022. In total, 8 types of spiritual care interventions were identified to assess spiritual needs and/or alleviate suffering: conversations between the patient and a team member, religious practice interventions, therapeutic presence, guided music therapy, multidisciplinary interventions, guided meditation, art therapy, and combined interventions with multiple components such as music, art, integrative therapy, and reflection.Significance of resultsOur study identified few spiritual care interventions in palliative care worldwide. Although this review noted a gradual increase in studies, there is a need to improve the reporting quality of spiritual care interventions, so they can be replicated in other contexts. The different interventions identified in this review can be a contribution to palliative care teams as they provide a basis for what is currently being done internationally to alleviate suffering in palliative care and what can be improved. No patient or public contribution was required to design or undertake this methodological research.
Toward Low‐Latency Estimation of Atmospheric CO2 Growth Rates Using Satellite Observations: Evaluating Sampling Errors of Satellite and In Situ Observing Approaches
Authors: Pandey Sudhanshu , Miller John B. , Basu Sourish , Liu Junjie , Weir Brad , Byrne Brendan , Chevallier Frédéric , Bowman Kevin W. , Liu Zhiqiang , Deng Feng , O’Dell Christopher W. , Chatterjee Abhishek 
Published: August 2024

AbstractThe atmospheric CO2 growth rate is a fundamental measure of climate forcing. NOAA's growth rate estimates, derived from in situ observations at the marine boundary layer (MBL), serve as the benchmark in policy and science. However, NOAA's MBL‐based method encounters challenges in accurately estimating the whole‐atmosphere CO2 growth rate at sub‐annual scales. Here we introduce the Growth Rate from Satellite Observations (GRESO) method as a complementary approach to estimate the whole‐atmosphere CO2 growth rate utilizing satellite data. Satellite CO2 observations offer extensive atmospheric coverage that extends the capability of the current NOAA benchmark. We assess the sampling errors of the GRESO and NOAA methods using 10 atmospheric transport model simulations. The simulations generate synthetic OCO‐2 satellite and NOAA MBL data for calculating CO2 growth rates, which are compared against the global sum of carbon fluxes used as model inputs. We find good performance for the NOAA method (R = 0.93, RMSE = 0.12 ppm year−1 or 0.25 PgC year−1). GRESO demonstrates lower sampling errors (R = 1.00; RMSE = 0.04 ppm year−1 or 0.09 PgC year−1). Additionally, GRESO shows better performance at monthly scales than the NOAA method (R = 0.76 vs. 0.47, respectively). Due to CO2's atmospheric longevity, the NOAA method accurately captures growth rates over 5‐year intervals. GRESO's robustness across partial coverage configurations (ocean or land data) shows that satellites can be promising tools for low‐latency CO2 growth rate information, provided the systematic biases are minimized using in situ observations. Along with accurate and calibrated NOAA in situ data, satellite‐derived growth rates can provide information about the global carbon cycle at sub‐annual scales.
Global Warming Favors Rapid Burial of Silver in the Vietnam Upwelling Area
Authors: Xu Liqiang , Liu Shiyan , Kong Deming , Liu Xiaodong , Ning Yu 
Published: August 2024

AbstractSilver is a highly toxic element for marine organisms. However, its controlling factor in marine sediments remains largely unknown, limiting our understanding of its biogeochemical cycling. Based on a sediment core from the Vietnam upwelling area in the South China Sea, it is found that Ag is significantly enriched in sediments of this area (as high as 0.39 μg/g), and it shows a very similar geochemical behavior to Ca and Sr. Our study supports the theory that Ag could be a marine paleo‐productivity indicator. Burial of Ag over the past 3,200 years shows an abrupt increase at around 1850 CE, in concordance with the global atmospheric CO2 record. It is hypothesized that elevated CO2 and global warming enhance marine productivity in the Vietnam coastal upwelling area, favoring the burial of Ag. Human‐induced global warming thus significantly impacts its biogeochemical cycling.