bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomogram for Predicting Efficacy and Prognosis After Chemotherapy for Advanced NSCLC
Authors: Gao Jiaying , Nan Yandong , Liu Gang , Zhao Shihong , Xiong Huanqing , Wang Yifeng , Jin Faguang 
Published: August 2024

ABSTRACTPurposeOne major issue is the therapeutic effect following chemotherapy for non–small cell lung cancer (NSCLC). Although numerous risk factors have been identified and novel therapies have been developed, improving patient overall survival (OS) remains a crucial postoperative issue. This study aimed to develop a nomogram for accurately predicting the OS of patients with Stage III–IV NSCLC treated with chemotherapy.MethodsThe Department of Respiration at Tangdu Hospital, Air Force Medical University, prospectively collected data on 321 patients between January 2018 and December 2023. A week before treatment, the platelet‐to‐lymphocyte ratio (PLR), the neutrophil‐to‐lymphocyte ratio (NLR), and seven autoantibodies were measured using Youden's index, which was obtained using the ROC curve. The formula was used to compute the values of PLR and NLR. After using multifactor Cox regression analysis to identify risk factors, a nomogram was produced regarding the therapeutic effect following chemotherapy. The performance of the nomogram was assessed using a bootstrapped‐concordance index and calibration plots.ResultIt was determined that NLR, sex‐determining region Y‐box 2 (SOX2), adenosine triphosphate binding RNA deconjugase 4–5 (GBU4‐5), and MAGE family member A1 (MAGEA1) were significantly associated factors that could be combined to accurately predict the therapeutic effect following chemotherapy. Utilizing these risk indicators, we were able to develop a nomogram that predicted the patients' survival at 1, 3, and 5 years. At 3 years, the area under the curve representing the expected survival probability was 0.762 (95% confidence interval 0.66–0.87). With a bootstrapped‐concordance index of 0.762, the nomogram demonstrated good calibration.ConclusionsOur nomogram proved to be a valuable instrument in accurately predicting the overall survival of patients.
Primary Lung Squamous Cell Carcinoma With Intestinal Metastasis: A Case Report and Literature Review
Authors: Tao Jin , Wu Zhiqiang , Huang Rongfei , Li Jun , Xu Tiewei , Gao Yujie , Jia Weikun , Chen Hu 
Published: August 2024

ABSTRACTLung squamous cell carcinoma (LUSC) is characterized by a high rate of metastasis and recurrence, leading to a poor prognosis for affected patients. Intestinal metastasis of LUSC is a rare clinical occurrence. Treatment options for LUSC patients with intestinal metastasis are limited, and no standard therapy guidelines exist for managing these cases. In this review, we discuss the clinical features, diagnosis, and treatment of LUSC patients with intestinal metastasis and present a rare case of LUSC with intestinal metastasis. We describe a patient who presented with a severe cough and chest pain and diagnosed with LUSC and bone tumor. Initially, the primary LUSC and bone tumor were controlled with standard treatments. However, the primary LUSC reoccurred shortly after treatment, this time with intestinal metastasis, for which effective treatments are lacking. Our observation from the case suggests that LUSC metastasizing to intestinal tract is associated with a poorer prognosis.
Radiological Features of Primary Pulmonary Invasive Mucinous Adenocarcinoma Based on 312 Consecutive Patients
Authors: Qi Linlin , Jia Jia , Zhang Guochao , Liu Jianing , Li Fenglan , Chen Jiaqi , Cui Shulei , Cheng Sainan , Xue Liyan , Xue Qi , Wang Jianwei 
Published: August 2024

ABSTRACTBackgroundThe aim of this study is to investigate the radiological features of primary pulmonary invasive mucinous adenocarcinoma (IMA) in a relatively large population to help improve its further understanding and its accuracy of initial diagnosis.MethodsThis retrospective study included consecutive patients with pathologically confirmed primary pulmonary IMA from January 2019 to December 2021. According to tumor morphology, IMAs were divided into regular nodule/mass, irregular, and large consolidative types. According to tumor density, IMAs were divided into solid, halo, part‐solid, pure ground‐glass, and cystic types. ANOVA, chi‐square, or Fisher exact tests were used to analyze the differences in radiological and clinicopathological characteristics of IMA according to morphological and density subtypes.ResultsWe analyzed 312 patients. Pulmonary IMA tended to occur in the elderly, with a slightly higher number of women than men. IMA showed a predominance in the lower lobe and adjacent to pleura. IMA of regular nodule/mass, irregular, and large consolidative types accounted for 80.8% (252/312), 13.8% (43/312), and 5.4% (17/312), respectively. Solid, halo, part‐solid, pure ground‐glass, and cystic IMAs accounted for 55.8% (174/312), 28.2% (88/312), 11.2% (35/312), 1.3% (4/312), and 3.5% (11/312), respectively. The lobulated (76.9%), spiculated (63.5%), and air bronchogram (56.7%) signs were common in IMA. Dead branch sign (88.2%), angiogram sign (88.2%), and satellite nodules/skipping lesions (47.1%) were common in large‐consolidative‐type IMA. Kirsten rat sarcoma viral oncogene mutations were common (56.1%), whereas epidermal growth factor receptor mutations were relatively rare (2.3%).ConclusionsPulmonary IMA of regular nodule/mass type and solid type were the most common at the initial diagnosis. Detailed radiological features can aid in the differential diagnosis of IMA.
Recommendations for incorporating invasive species into U.S. climate change adaptation planning and policy
Authors: Brewington Laura , Rodgers LeRoy , Greenwood Leigh 
Published: August 2024

AbstractExecutive Order No. 14008 mandated that U.S. federal agencies and departments develop Climate Change Adaptation Plans to enhance the nation's resilience to climate change. Invasive species are documented to reduce the effectiveness of climate adaptation and mitigation actions. In spite of this, only eight of the 26 federal plans directly reference invasive species, and just four meaningfully consider the reciprocal impact of invasive species on climate adaptation efforts. To ensure that climate adaptation planning and processes are effective with associated benefits for biodiversity conservation, a gap analysis of the Climate Change Adaptation Plans was conducted. Five key recommendations were developed that would transform how invasive species are considered within them. Examples of how invasive species have been included in some of the plans are provided, with suggestions for agencies that did not include invasive species on how they might do so, to illustrate that dedicated efforts in prevention, detection, and management of invasive species can safeguard carbon sequestration, protect communities and infrastructure, and minimize economic and biodiversity losses. Although developed based on U.S. federal plans, these recommendations can be used by state and local, as well as international, jurisdictions tasked with implementing climate‐adaptive policies to build resilience across multiple sectors.
Intravenous treatment of calcinosis cutis with sodium thiosulfate – A case series
Authors: Bruns Tom , Sunderkötter Cord , Wohlrab Johannes 
Published: August 2024

SummaryCalcinosis cutis is defined as the deposition of calcium salts in the skin. The dystrophic form is the most common and usually occurs in chronic inflammatory processes associated with collagenoses. Therapeutic options include surgical excision as well as a few pharmacological treatments. Overall, the evidence for the known therapeutic interventions is very limited and there is a lack of valid recommendations. Intravenous sodium thiosulfate has been used successfully in the treatment of calciphylaxis. In our case series, five patients with dystrophic calcinosis cutis received intravenous sodium thiosulfate for at least six cycles on five consecutive days per month, with single doses of 12.5 g and 25.0 g, respectively. A reduction in the calcified lesions could not be proven with certainty, but stable disease conditions were achieved. Intravenous sodium thiosulfate may counteract the progression of calcinosis cutis. The successful use of epicutaneously applied sodium thiosulfate, as described in the literature, suggests that a higher cutaneous bioavailability can be achieved to exert a lytic effect on calcinosis cutis. This is further supported by the reported efficacy of high‐dose sodium thiosulfate in the treatment of calciphylaxis.
Islands of ice: Glacier‐dwelling metazoans form regionally distinct populations despite extensive periods of deglaciation
Authors: Janko Karel , Shain Daniel H. , Fontaneto Diego , Kaštánková Doležálková Marie , Buda Jakub , Štefková Kašparová Eva , Šabacká Marie , Rosvold Jørgen , Stefaniak Jacek , Hessen Dag Olav , Devetter Miloslav , Jimenez/Santos Marco Antonio , Horna Patrik , Janková Drdová Edita , Yde Jacob Clement , Zawierucha Krzysztof 
Published: August 2024

AbstractAimGlaciers cover considerable portion of land and host diverse life forms from single‐celled organisms to invertebrates. However, the determinants of diversity and community composition of these organisms remain underexplored. This study addresses the biogeography, population connectivity and dispersal of these organisms, especially critical in understanding during the rapid recession of glaciers and increased extinction risk for isolated populations. By reconstructing the Quaternary biogeographic history of Fontourion glacialis, a widespread in Northern Hemisphere glacier obligate species of Tardigrada, we aim to understand how populations of glacier‐dwelling metazoans receive immigrants, respond to disappearing glaciers and to what extent remaining glaciers can serve as refugia.LocationGlaciers across Svalbard, Scandinavia, Greenland and Iceland.MethodsWe analysed mtDNA (COI gene) variability of 263 F. glacialis specimens collected across the distribution range. Phylogeographic and coalescent‐based approaches were used to detect population differentiation patterns, investigate most likely models of gene flow and test the influences of geographical and climatic factors on the distribution of F. glacialis genetic variants.ResultsOur findings indicate that the distribution of F. glacialis genetic variants is primarily influenced by geographical rather than climatic factors. Populations exhibit a dispersal‐limited distribution pattern, influenced by geographical distance and local barriers, even between neighbouring glaciers. Significantly, the genetic structure within Scandinavia suggests the existence of “southern” glacial or low‐temperature refugia, where F. glacialis may have survived a period of extensive deglaciation during the Holocene climatic optimum (8–5 kyr ago).Main ConclusionThe study uncovers complex metapopulation structures in F. glacialis, with impacts of local barriers, population bottlenecks as well as historical ice sheet fluctuations. It suggests that such populations can endure extended periods of deglaciation, highlighting the resilience of glacial refugia. The study highlights the necessity of understanding the diversity and population structure of ice‐dwelling fauna in both spatial and temporal contexts.
Outcomes of noncurative endoscopic submucosal dissection for T1 colorectal cancer: Prospective, multicenter, cohort study in Japan
Authors: Tsuji Shigetsugu , Doyama Hisashi , Kobayashi Nozomu , Ohata Ken , Takeuchi Yoji , Chino Akiko , Takamaru Hiroyuki , Tsuji Yosuke , Hotta Kinichi , Harada Keita , Ikematsu Hiroaki , Uraoka Toshio , Murakami Takashi , Katagiri Atsushi , Hori Shinichiro , Michida Tomoki , Suzuki Takuto , Fukuzawa Masakatsu , Kiriyama Shinsuke , Fukase Kazutoshi , Murakami Yoshitaka , Ishikawa Hideki , Saito Yutaka 
Published: August 2024

ObjectivesThis study investigated the incidence of lymph node metastasis and long‐term outcomes in patients with T1 colorectal cancer where endoscopic submucosal dissection (ESD) resulted in noncurative treatment. It is focused on those with deep submucosal invasion, a factor considered a weak predictor of lymph node metastasis in the absence of other risk factors.MethodsThis nationwide, multicenter, prospective study conducted a post‐hoc analysis of 141 patients with T1 colorectal cancer ≥20 mm where ESD of the lesion resulted in noncurative outcomes, characterized by poor differentiation, deep submucosal invasion (≥1000 μm), lymphovascular invasion, high‐grade tumor budding, or positive vertical margins. Clinicopathologic features and patient prognoses focusing on lesion sites and additional surgery requirements were evaluated. Lymph node metastasis incidence in the low‐risk T1 group, identified by deep submucosal invasion as the sole high‐risk histological feature, was assessed.ResultsLymph node metastasis occurred in 14% of patients undergoing additional surgery post‐noncurative endoscopic submucosal dissection for T1 colorectal cancer. In the low‐risk T1 group, in the absence of other risk factors, the frequency was 9.7%. The lymph node metastasis rates in patients with T1 colon and rectal cancers did not differ significantly (14% vs. 16%). Distant recurrence was observed in one patient (2.3%) in the ESD only group and in one (1.0%) in the additional surgery group, both of whom had had rectal cancer removed.ConclusionThe risk of lymph node metastasis or distant occurrence was not negligible, even in the low‐risk T1 group. The findings suggest the need for considering additional surgery, particularly for rectal lesions (Clinical Trial Registration: UMIN000010136).
Joint effects of sleep disturbance and renal function impairment on incident new‐onset severe metabolic dysfunction‐associated steatotic liver disease
Authors: Tian Tian , Zeng Jing , Li Yuan‐Cheng , Wang Jing , Zhang Dan‐Feng , Wang De‐Guang , Pan Hai‐Feng , Fan Jian‐Gao , Ni Jing 
Published: August 2024

AbstractAimTo elucidate the effects of sleep parameters and renal function on the risk of developing new‐onset severe metabolic dysfunction‐associated steatotic liver disease (MASLD).Materials and MethodsThe primary analysis involved a cohort of 305 257 participants. Multivariable Cox models were employed to calculate hazard ratios and 95% confidence intervals. Traditional mediation and two‐step Mendelian randomization (MR) analyses were conducted to assess the associations and mediating roles of renal function indicators between sleep and new‐onset severe MASLD.ResultsPoor sleep score and renal function biomarker score (RFS) were associated with an increased risk of new‐onset severe MASLD (all ptrend <0.001). Participants with poor sleep patterns and the highest RFS had a 5.45‐fold higher risk of new‐onset severe MASLD, compared to those with healthy sleep patterns and the lowest RFS (p < 0.001). The RFS could explain 10.08% of the correlations between poor sleep score and risk of new‐onset severe MASLD. Additionally, MR analyses supported a causal link between insomnia and new‐onset severe MASLD and revealed a mediating role of chronic kidney disease in the connection between insomnia and new‐onset severe MASLD risk.ConclusionsThis study highlights the independent and combined associations of sleep parameters and renal function indicators with new‐onset severe MASLD, underscoring the bidirectional communication of the liver–kidney axis and providing modifiable strategies for preventing MASLD.
VibePy: An open‐source tool for conducting high‐fidelity vibrational playback experiments
Authors: Evora Alana J. , Cocroft Reginald B. , Madhusudhana Shyam , Hamel Jennifer A. 
Published: August 2024

AbstractMany insect species communicate about activities central to their survival and reproduction via vibrational signals (i.e., waves that travel through solid substrates). One widely used and effective approach for testing hypotheses about communication is the playback experiment, in which stimuli are played to focal organisms and their responses are documented. Recent technological advances and efforts by vibrational communication researchers have diversified the hardware options available for use in such experiments, but proprietary software is still needed for high‐fidelity playbacks. Here, we present an open‐source software tool, VibePy, that (1) measures and compensates for undesired filtering and (2) calibrates playback amplitude. Because proprietary software licenses impose economic barriers that can limit access to research, we have developed VibePy in the open‐source language Python. The functions provided by VibePy are a stepping stone toward increasing access to vibration research. Because the tool is open‐source, we hope that the software will be expanded upon by others in the community of researchers studying vibrational communication and insect behavior.
Quietist Elements in Adorno
Authors: Lamp Christian 
Published: August 2024

AbstractIn this article I take a closer look at Adorno's methodology, and specifically the question of how – in Adorno's view – philosophy ought to be done. In this, my aim is to see whether there might be ‘quietist’ elements in his methodological account, i.e. the meta‐philosophical position of quietism as it stands against (scientific) naturalism in recent discussions. Recent work on Adorno and classical critical theory has discussed numerous similarities and overlaps with the post‐analytical work of, e.g., John McDowell and Michael Thompson. Building on this recent work, my article suggests further points of contact, by focusing on the interplay of question and answer present in both McDowell and Adorno. To do this, I first outline McDowell's version of quietism. From there, an interpretation of Adorno can proceed along the lines developed with McDowell, centering the idea of unanswerable philosophical questions that need to be treated instead of answered straightforwardly. I demonstrate the relation he draws from disappearance of questions to ‘praxis’ and suggest how this differs from McDowell yet might still be viewed as an account related to quietism. I conclude by suggesting taking up Adorno's term ‘immanent criticism’ as a methodological concept.
Does leisure crafting improve workplace creativity?
Authors: Chen I‐Shuo , Choi Jin Nam 
Published: August 2024

AbstractWorkplace creativity is essential for organizational survival and growth. With the prevailing focus on work conditions and employee motivation for creativity, it remains unclear whether and how employees can make creative contributions through proactive engagement in their private lives. This study aims to explore the development of workplace creativity from the non‐work perspective of individual proactivity. Drawing upon conservation of resources theory, we investigate if leisure crafting improves workplace creativity by promoting playful work design. The hypotheses were tested using multi‐wave field data collected from 365 employees. We revealed that leisure crafting contributes to playful work design, including fun and competition, especially when a smartphone is used for leisure purposes. Leisure crafting also has direct and indirect effects on creative performance through playful work design. The current analysis offers insights into how proactivity and resources gained from the non‐work domain can improve workplace outcomes by enabling work‐related proactive behavior.
Alpha‐amanitin tolerance of adult flies of mycophagous and nonmycophagous species in Drosophilidae
Authors: Zhang Yang , Toda Masanori J. , Watabe Hide‐aki , Katoh Toru 
Published: August 2024

AbstractMushrooms produce a great variety of defense chemical compounds to protect themselves from fungivores. Alpha‐amanitin is one of such compounds found in some Amanita mushrooms. The present study focuses on the effect of α‐amanitin on adult survival in 17 drosophilid species including mycophagous ones from the subgenus Drosophila and the genus Hirtodrosophila and nonmycophagous ones of the subgenera Drosophila, Siphlodora and Sophophora. The results showed that all the essential fungivores and some partially mycophagous species from different lineages are tolerant to this lethal toxin at a concentration of 50 μg/mL, suggesting that the α‐amanitin tolerance may have been acquired more or less independently of the evolution of mycophagy in the family Drosophilidae.
A novel case report of clockwise and counterclockwise uterine torsions during the same gestation period in a mare
Authors: Derbala Mohamed K. , Hassan Marwa H. , Abu‐Seida Ashraf M. 
Published: August 2024

SummaryUterine torsion (UT) is a common obstetrical problem in Straight Egyptian Arabian mares, causing a medical emergency for both the mare and the fetus. This case report describes, for the first time, the management of a case of UT in both directions during a single gestation period in a 5‐year‐old Straight Egyptian Arabian mare. The mare was 8 months pregnant and experienced intermittent unresponsive colic signs. Rectal examination revealed clockwise 180° UT and ultrasonography showed a viable fetus. The haematological findings were within the normal range. The mare was surgically treated immediately by standing flank laparotomy (SFL) on the right side. 4 days later, the mare was returned to the clinic with the same complaint. Rectal and ultrasonography examinations revealed counterclockwise 180° UT and a viable fetus. The animal was subjected again to SFL on the left side. After surgeries, the mare recovered well, foaled at term and gave birth to a viable filly. She was bred again and conceived. This case is documented to demonstrate the occurrence of a UT in both directions during the same gestation period in mares, as well as the efficacy of SFL in rectifying the condition and allowing both the mother and foal to survive.
Nrf2 cell signaling pathway is responsible for the antioxidant effect of resveratrol in aging
Authors: Franco Filipe Nogueira , Arrieta Orlando Alfredo Pineda , de Mello Silva Breno , Aragão Matheus Motta , Nagem Ronaldo Alves Pinto , de Araújo Glaucy Rodrigues , Chaves Miriam Martins 
Published: August 2024

IntroductionOne of the markers of aging is oxidative stress, a condition characterized by an increase in free radicals concomitant with a reduction in antioxidant defenses. Within this, resveratrol is a compound that has been shown to act as a potent antioxidant. However, few studies highlight the cellular signaling pathways that are activated or inhibited during aging and that are responsible for this biological effect.AimTo verify the antioxidant profile of resveratrol (5 μM) in leukocytes from donors in different age groups.MethodsThe project was approved by the Ethics Committee. Individuals were divided into three groups: 20–39, 40–59, and 60–80 years old. After separating the leukocytes, assays were performed to evaluate the AMPK (AMP‐activated protein kinase) and Nrf2 (erythroid nuclear factor 2‐related factor 2) pathways. In addition, luciferase assay and enzyme‐linked immunosorbent assay were performed to evaluate transcription factor activation and Nrf2 expression, respectively. The analysis between age and treatment was performed using Pearson correlation (*P < 0.05).ResultsThere was a reduction in the antioxidant effect of resveratrol during the aging process. In leukocytes from donors over 60 years of age, the AMPK pathway was silenced. Nrf2 was active at all ages. There was an increase in the activation of the transcription factor and phosphorylated protein in all age groups.ConclusionsNrf2 is an important biochemical mechanism responsible for the antioxidant effect of resveratrol. This effect diminishes with aging but is still observed. Geriatr Gerontol Int 2024; 24: 954–961.