bluuebunny/crossref_metadata_2025_split huggingface dataset:
PIGMENTED FRECKLES ON THE SOLE AS ACRAL LENTIGINOUS MELANOMA IN SITU
Authors: Kato Taizo , Tanita Yasuo , Takematsu Hideaki , Tagami Hachiro 
Published: April 2015

ABSTRACTWe report a rare case presenting a very early, non‐invasive stage of acral lentiginous melanoma (ALM). A 67‐year‐old male patient came to our clinic 4 days after he noticed the presence of a pigmented lesion on the sole of his right heel.The lesion exhibited an irregular, asymmetrical outline and haphazard combination of colors ranging from tan to brown black; it measured 3.2 times 2.1 cm in its greatest dimensions. It was not elevated. It was surgically removed.Histopathologically, serial sections of the lesion revealed an increase in large atypical melanocytes. These abnormal cells with irregular in shape and relatively hyperchromatic nuclei, were mainly located in the basal layer, resulting in the proliferation of lentiginous type. These findings are clinically and histopathologically identical to those found in ALM in situ.
NEUROCUTANEOUS MELANOSIS
Authors: Yu Hsin‐Su , Tsaur Keh‐Chang , Chien Chung‐Ho , Perng Jyi‐Jiang , Lu Chu‐Chong 
Published: April 2015

ABSTRACTThis is a report of a 28‐day‐old male infant who had concommitant pigmented melanocytic nevi and meningeal melanosis. Pigment cells of the two lesions were observed by electron microscopy and compared with previous reports of nevus cell nevus, meningeal melanosis, meningeal melanocytoma and leptomeningeal malignant melanoma. Based on our findings, we have reached the following three conclusions: (1) Pigment cells in the nevus and meningeal melanosis in our case were similar in their cellular structures and their relationship to blood vessels and consistent with a neural crest origin for pigment cells; (2) Ultrastructural characteristics of the meningeal melanosis in our case were similar to those of the meningeal melanocytoma; (3) Pigment cells in meningeal melanosis have tumorous potential and may tend to cause malignant changes.
MULTIPLE CUTANEOUS PLASMACYTOMAS OBSERVED IN IgD MYELOMA
Authors: Horiuchi Yasuhiro , Ohbu Makoto , Kanzaki Tamotsu 
Published: April 2015

ABSTRACTA 79‐year‐old Japanese male patient with multiple cutaneous plasmacytomas in IgD‐lambda myeloma is described. Initially, a very small amount of IgM paraprotein could be detected. This case was very aggressive clinically with prominent cutaneous involvement.
SKIN ELASTICITY IN PSORIASIS
Authors: Serup Jørgen , Northeved Allan 
Published: April 2015

ABSTRACTThe skin elasticity of psoriasis plaques was measured in 10 patients suffering from psoriasis vulgaris with a recently introduced in vivo method with high reproducibility. The method is based on repeated applications of suction to a 0.79cm2 circular skin area, and measurement of tensile distensibility (TD), hysteresis (H) and resilient distension (RD) by the principle of electrical capacitance as calibrated with distance. Measurements of 23 plaques showed a decrease in TD and increases in H and RD when compared to regional control measurements. Experiments in 19 control regions with histamine skin‐pricks to evaluate the effects of cutaneous oedema on skin rheology showed that TD as well as H and RD became increased. The skin thickness of the plaques was increased by 68% as a mean, probably resulting from oedema of the outer dermis. The decreased TD, representing a component of stiffness, is probably related to a fixed zone of interdigitation between elongated and club‐shaped rete ridges and oedematous papillae while the increase in H and RD, representing a component of softness, is probably explained by the oedema of the outer dermis. Analyses of the relation between increase in thickness and rheology indicated that, in more advanced plaques, the skin may be in a state of mechanical locking with low hysteresis.
PORPHYRIA CUTANEA TARDA SYMPTOMATICA IN CHILDREN TREATED WITH CHLOROQUINE: REPORT OF FOUR CASES WITH CONTROL LIVER BIOPSIES
Authors: Tamayo Lourdes , Maldonado Ramon Ruiz , Ridaura Cecilia 
Published: April 2015

ABSTRACTFour children with porphyria cutanea tarda symptomatica were reported. Two of them had a previous history of exposure to pesticides. All four received a daily treatment of 250 mg of chloroquine for seven days. Liver function test results were altered immediately after conclusion of the therapy and porphyrin levels were very high.A light and electron microscopic examination of eight control liver biopsies revealed fatty changes before treatment, extensive liver damage during treatment, and regeneration of the liver parenchyma after the treatment.In view of the transient, but severe, liver damage, this therapeutic modality is not recommended for the treatment of children with porphyria cutanea tarda.
GIANT IRRITATED SEBORRHEIC KERATOSIS MIMICKING VERRUCOUS CARCINOMA
Authors: Mochizuki Takashi , Fujigaki Tomomasa , Tanaka Soichi , Hironaga Masaki 
Published: April 2015

ABSTRACTA case of giant irritated seborrheic keratosis is reported. The tumor showed an unusually gross appearance for seborrheic keratosis; hence, before surgery, it was suspected of being a verrucous carcinoma. However, examination of the whole histologic constitution of the excised tumor warranted the diagnosis of irritated seborrheic keratosis.
BASAL CELL EPITHELIOMA WITH GIANT TUMOR CELLS
Authors: Ono Tomomichi , Egawa Kiyofumi , Higo Junko , Fallas Victor Hugo 
Published: April 2015

ABSTRACTTwo cases of basal cell epithelioma with giant tumor cells are reported. Differentiation into squamoid cells and phagocytosis of melanosomes and remnants of the degenerated tumor cells may be factors in initiating giant cell formation. The localization of these giant tumor cells into specific nests suggests the presence of unknown factors contributing to their formation.
PAPULONECROTIC TUBERCULID WITH INFLAMMATORY NODULAR LESIONS OF THE LOWER LEG
Authors: Yoshikawa Kunihiko , Kimura Shigeru , Mizuno Nobuyuki 
Published: April 2015

ABSTRACTTwo cases of papulonecrotic tuberculid (PNT) with inflammatory nodules of the lower leg are reported. One is a 43‐year‐old woman with lymphadenitis tuberculosa, and the other is a 54‐year‐old man with penis tuberculid and epididymitis of possible tuberculous etiology. In both cases, PPD skin test was strongly positive, and antituberculous therapy was markedly effective. Although the theory of the etiology of PNT is changing due to the recent decrease in active tuberculosis, we think that one cause of so‐called PNT is still tuberculosis, at least in Japan.
IDIOPATHIC CALCINOSIS OF THE SCROTUM
Authors: Nakamura Shinichi , Imai Toshiya , Nakayama Keiji 
Published: April 2015

ABSTRACTA 38‐year‐old man with idiopathic calcinosis of the scrotum was reported. There was no increase in serum calcium and phosphorus levels. Histologically, the picture was fairly typical with amorphous calcium deposits in the dermis and foreign body reaction, but the epithelial walls observed in such diseases as epidermal cyst or pilar cyst were not seen.
BIOCHEMICAL STUDIES OF EXPERIMENTAL PORPHYRIA
Authors: Shimoyama Tokio , Nonaka Shigeo , Honda Tetsuzo , Ohgami Taro , Murayama Fumio , Yoshida Hikotaro 
Published: April 2015

ABSTRACTOur previous study showed that a 0.1% concentration of griseofulvin (GF) in feed induced an abnormality of porphyrin metabolism in some dd‐K strain mice. To investigate the kind of changes in porphyrin metabolism that would be produced by other chemicals compared to the administration of 0.1% GF alone, estrogen, ethyl alcohol‐iron mixture and PCB was given to dd‐K strain mice. The numbers of mice with high liver protoporphyrin levels were increased in the group treated with both 0.1% GF and ethyl alcohol‐iron mixture, in comparison to the levels in the 0,1% GF alone and the ethyl alcohol‐iron mixture alone groups. A slight elevation in the liver protoporphyrin level was noted in only one mouse of the ethyl alcohol‐iron mixture group. The remaining mice showed normal levels. From this finding, it was presumed that the administration of ethyl alcohol‐iron mixture has the potential to intensify the activity of 0.1% GF alone. An elevation of the liver coproporphyrin and protoporphyrin levels was seen in the group treated with both 0.1 % GF and estrogen, as compared to the 0.1% GF alone and the estrogen alone groups. In those treated with estrogen alone, liver porphyrin levels were within normal limits except for one mouse, which showed an increase of liver protoporphyrin. An elevation of liver coproporphyrin and protoporphyrin was seen in 8 of 12 mice treated with both PCB and 0.1% GF, while there was no change in the PCB alone group. From these findings, it was inferred that the mechanism of abnormal porphyrin metabolism due to estrogen and PCB combined with 0.1% GF differs from the mechanism of abnormality due to 0.1% GF alone. It appears that the addition of some chemicals to a 0.1% GF feed enhances the action of the 0.1% GF alone.
NEUTROPHIL MIGRATION IN GRANULOMA ANNULARE: COMPARATIVE STUDY BETWEEN LOCALIZED AND GENERALIZED TYPES AND BETWEEN ACTIVE AND REGRESSIVE STATES
Authors: Friedman‐Birnbaum Rachel , Bergman Reuven , Obedeanu Nora , Meshulam Tova , Merzbach David 
Published: April 2015

ABSTRACTIn vitro neutrophilic leukocyte (NL) chemotaxis was studied in patients with granuloma annulare (GA). Chemotaxis of NL from patients with the generalized form of the disease (GGA) was compared to that from patients with the localized form (LGA). A similar comparison was also made between patients in the active state of the disease versus those in regression. No significant differences were observed between any of the GA patients' values and a matched control group, nor were the observed differences statistically significant when NL migration was compared in patients with GGA versus LGA or in patients having the active form of the disease as compared to those in regression. In an attempt to detect eventual effects of control sera on patients' NL or of patients' sera on control NL, the sera and leukocytes were cross‐reacted in chemotactic assays. The results did not show any effect of crossing sera and cells. Taken together, these data fail to indicate any possible role for NL chemotactic activity in GA.
ATYPICAL CUTANEOUS HEMANGIOMA—A SKIN SIGN OF AORTITIS SYNDROME?
Authors: Ikeda Masami , Arata Jirô , Masuda Toshiki 
Published: April 2015

ABSTRACTA 52‐year‐old man had an atypical cutaneous hemangioma on the right side of his neck. He had suffered from hypertension since he was 20 years old with marked differences in blood pressure in each arm. He had no other clinical symptoms. Angiography revealed that the patient had a typical aortitis syndrome which included obstruction of the left common carotid artery, stenosis of the left subclavicular artery, stenosis of both renal arteries and an irregular shadow of the abdominal aorta. On the area of the skin lesion there were a slightly dilated feeding artery and an obscure net work of arteries. No sign of direct A‐V shunt was seen. This hemangioma could be pure capillary malformation in the angiographic classification by Merland et al. Renin activity and angiotensin I were high. Histopathological examination of the skin lesion revealed dilatation and enlargement of small veins in the upper dermis and increased arteries and veins of medium size from the deep dermis to subcutaneous fat tissue. This atypical cutaneous hemangioma is thought to be an important skin marker for this syndrome.
mRNA ACTIVITY OF M‐TYPE LACTATE DEHYDROGENASE IN DERMATOFIBROSARCOMA PROTUBERANS
Authors: Ozasa Hisashi , Shindo Yasuko 
Published: April 2015

ABSTRACTThe enzyme activity and mRNA level of M‐type lactate dehydrogenase (LDH) were studied in dermatofibrosarcoma protuberans (DFSP), a low grade sarcoma of the skin with a long clinical course and pronounced tendency toward progression and local recurrence. The isoenzyme pattern of LDH in DFSP was quite similar to that of other malignant skin tumors. The total LDH activity, ratio of M‐type activity, and mRNA level of M‐type LDH in DFSP were higher than those in control skin. It is suggested that this higher enzyme activity of M‐type LDH in DFSP was mainly due to the higher activity of mRNA coding for M‐type LDH.
ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL IDENTIFICATION OF MALIGNANT SCHWANNOMA OF THE SKIN
Authors: Nomiyama Tomohiko , Hornstein Otto P. 
Published: April 2015

ABSTRACTHistogenetic identification of poorly differentiated spindle cell tumours can be very difficult if only routine histology is used. In the case of a 64‐year‐old man suffering from a recurrent and spreading malignant tumour on his neck, the precise diagnosis of malignant schwannoma was not established until a skin node was examined by electron microscopy. The neurogenic nature of the neoplasm was additionally confirmed by demonstration of S 100 protein within most of the tumour cells. Ultrastructurally, the tumour was composed predominantly of atypical Schwann cells and, in varying number, of perineurial cells, endoneurial cells and some myofibroblasts exhibiting features enabling their differentiation. Some electron microscopical findings not previously reported in malignant schwannoma were detailed.
A CASE OF BENIGN MESENCHYMOMA CONTAINING CARTILAGEOUS TISSUE COMPONENTS WITH ENCHONDRAL OSSIFICATION
Authors: Setoyama Mitsuru , Miyauchi Hideaki , Kanekura Takuro , Tashiro Masaaki 
Published: April 2015

ABSTRACTA 50‐year‐old man with benign mesenchymoma containing cartilageous tissue components with enchondral ossification was reported. The tumor was located in the soft tissue of the right leg. Microscopically, it was composed of lipomatous, myxolipomatous or angiolipomatous, hemangiomatous, myxomatous, and fibrous connective tissue in addition to the ossifying cartilageous tissue components. We have found 21 cases of benign mesenchymoma in the Japanese literature and determined that our case with cartilageous components showing enchondral ossification was unique among a variety of well‐differentiated mesenchymal components.
A CASE OF IMPETIGO HERPETIFORMIS WITH HYPERCALCITONINEMIA
Authors: Nitta Yukiko , Yasue Takashi 
Published: April 2015

ABSTRACTA 22‐year‐old woman suffering from impetigo herpetiformis with accompanying hypocalcemia and hypercalcitoninemia during her first pregnancy is reported. No symptoms of hypothyroidism were observed. She responded to treatment with prednisone and gave birth to a female infant by normal delivery. Hypocalcemia and hypercalcitoninemia were normalized after delivery. Two years after delivery her eruptions have not recurred.
A Serine Proteinase from Cow Snout Epidermis Degrades High Molecular Weight Keratins
Authors: Toku Seikichi , Inoue Fumihide , Nakada Fukuichi 
Published: April 2015

AbstractThis study describes a serine proteinase which degrades high molecular weight polypeptides of keratins. The enzyme was coextracted with 8M urea together with keratins and separated from the keratins by gel filtration chromatography. Molecular weight of the enzyme was estimated at 25,000 daltons by gel filtration. Revealed characteristics of the enzyme were as follows; 1) maximally active at pH 8.5–9.0, 2) requires 0.04% SDS for maximum activity, 3) heat stable in the absence of SDS up to 65°C for 2 min, 4) sensitive against serine protease inhibitor, phenylmethanesulfonyl fluoride and soybean trypsin inhibitor, 5) highly specific for natural protein substrates, such as keratin polypeptides.
Hepatitis B Serum Markers in Porphyria Cutanea Tarda
Authors: Valls V. , de Salamanca R. Enriquez , Lapeña L. , Campos I. , Ena J. , Guerra P. , Rebollar J.L. 
Published: April 2015

AbstractHepatitis B virus (HBV) infection was studied in 100 patients with porphyria cutanea tarda (PCT). The overall prevalence of HBV serologic markers was 57%: 6 patients had HBsAg, 9 had antiHBc alone, 2 had antiHBc associated with antiHBe and the remaining 40 patients had antiHBs.The seropositivity frequency was significantly related to the age of patients and to previous venesection treatment but was unrelated to previous hepatitis or risk factors, amount of alcohol consumption, abnormalities of serum iron levels, liver function tests, or hepatosiderosis.Seropositive patients showed more severe histological abnormalities than seronegative patients.Our results indicate that PCT should be considered a high risk disorder for HBV infection and that this agent may play an important role in aggravating the underlying liver damage.
The Immunohistopathologic Study of Scabies by the PAP Method — Identification of IgE Positive Mast Cells
Authors: Hayashi Masayuki , Uchiyama Mitsuaki , Nakajima Hiroshi , Nagai Ryukichi 
Published: April 2015

AbstractSkin biopsy specimens taken from 18 cases of scabies were studied immunohistopathologically using the PAP method. In 12 of 18 cases, membrane‐bound, IgE positive mast cells were observed in the dermis and subcutaneous tissues of the scabies lesions. In a Norwegian scabies, IgE deposits were found not only on the surface of scabies mites but also on feces‐like granules. We conclude that the membrane‐bound IgE mast cells may play an important role in immune skin reactions of scabies.
UVA Induced Darkening of Lower Epidermal Cells as an in vitro System of Immediate Pigment Darkening (IPD) and Mechanisms of IPD
Authors: Sawamura Daisuke , Sato Shizuo , Kiuchi Hiyoshi , Hashimoto Isao , Katabira Yasuo 
Published: April 2015

AbstractImmediate pigment darkening (IPD), which is a skin tanning reaction induced by UVA or visible light irradiation, is generally thought to result from photo oxidation of pre‐existing melanin. Only a few in vitro systems useful for studying the detailed mechanisms have been developed. The purpose of this study is to present UVA‐induced darkening at the cell level in an in vitro system and clarify the mechanisms of IPD.Human lower epidermal cells (LECs) separated by the Percoll density gradient centrifugation and murine B16 malignant melanoma cells (B16Cs) were treated to prepare a melanin containing, pyridine‐insoluble precipitate (PUP). The degree of darkness of the UVA‐exposed cells was expressed as reflectance at 400 nm (RE) from PUP. With increasing UVA dose, the RE from B16C‐PUP induced no significant change, but the RE from LEC‐PUP decreased. Thus the model of UVA‐induced darkening at the cell level using LEC was successful. Measurement of the height of electron spin resonance (ESR) signal from PUPs of whole epidermal cells and of B16Cs revealed a 10% decrease in the former and no significant change in the latter after UVA treatment. These results suggest that a combination of the melanin in intracellular melanosomes and UVA exposure alone did not induce melanin darkening of IPD, and also that the semiquinoid form of melanin monomeric units decreased in the keratinocyte melanin. Taking into consideration the molecular structure of melanin, these results also suggest that photo oxidation of melanin monomeric units from the semiquinoid to the quinoid form is one of the mechanisms of IPD causing the darkening of melanin pigment.
Immunohistochemical and Electron Microscopic Observations in Granular Cell Tumors
Authors: Kishimoto Saburo , Arita Tsugihisa , Koishi Kazuo , Hirano Shinya , Ikada Junji 
Published: April 2015

AbstractTwo cases of granular cell tumor (GCT) of the skin were examined immunohistochemically for the presence of S‐100 protein (S100), myelin basic protein (MBP), glial fibrillary acidic protein (GFA), serotonin, and B‐2‐microglobulin (B2M). One of the tumors was also observed by electron microscopy. The tumor cells in both cases showed positive staining for S100 and B2M. Although immunoreactive MBP was not found in the tumor cells, it was observed in the nerve fascicles and the nerve fibers in the stroma. Staining for GFA and serotonin was negative. The electron microscopic findings showed that a large number of the tumor cells appeared to be in the final stage, showing structureless cytoplasm with various granules and vacuoles.Since S100 appears to be a marker for Schwann cells, the expression of S100 by GCT supports its neural genesis.
A Unique Case of Subepidermal Bullous Disease
Authors: Toda Ken‐ichi , Horiguchi Yuji , Imamura Sadao 
Published: April 2015

AbstractA 72‐year‐old Japanese woman developed small, asymptomatic, subepidermal vesicles on the limbs, back, chest and abdomen. Immunoperoxidase staining of the lesional skin showed linear deposition of IgG, IgA and C3 along the basement membrane zone (BMZ), and indirect immunofluorescence studies revealed IgG and IgA class circulating anti‐BMZ auto‐antibodies in the patient's serum. Ultrastructurally, the vesicles were caused by dermo‐epidermal separation at the lamina lucida, and the immune deposits were located just beneath the basal lamina in a band‐like pattern. Immunoelectron microscopic observation of normal human skin incubated with the patient's serum using an organ culture system revealed that the anti‐BMZ antibodies reacted with the anchoring fibrils. Administration of dapson was not effective, but betamethasone was. This case of subepidermal bullous disease is unique and cannot be classified into any existing category of bullous dermatoses.
Three Cases of Erythema Nodosum Associated with Yersinia Enterocolitica Infection
Authors: Ikeya Toshihiko , Mizuno Eiji , Takama Hiromichi 
Published: April 2015

AbstractThree cases of erythema nodosum associated with Yersinia enterocolitica infection were reported. They were diagnosed as Yersinosis following isolation of Yersinia enterocolitica from the feces and from serological investigation.The diagnosis was supported by the fact that Yersinia enterocolitica could be separated from the feces at an early stage of infection and that the serum agglutination titer for Yersinia enterocolitica increased within a month of infection.Clinically, the erythema nodosum preceded by abdominal pain and/or diarrhea was a complication of Yersinosis.
Lupus Like Syndrome Induced by 2‐Mercaptopropionylglycine
Authors: Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractA 49‐year‐old woman developed a lupus like syndrome with transient positive ANF and persistent leukocytopenia. The causative agent for the development of the disease was thought to be 2‐mercaptopropionylglycine (thiopronine), a drug similar to D‐penicillamine in structure and function. Skin rashes and arthralgia disappeared shortly after the withdrawal of the drug but positive ANF and leukocytopenia persisted for a relatively long period.
Satellite Cell Necrosis in Two Cases with Dermatomyositis
Authors: Katayama Ichiro , Hashimoto Takenori , Nishioka Kiyoshi 
Published: April 2015

AbstractSatellite cell necrosis phenomenon was demonstrated in tissue specimens from two patients with dermatomyositis during the acute phase of the disease. They had not undergone bone marrow transplantation or blood transfusion before the onset of the disease. During the clinical course, both patients developed high fever and prominent muscle weakness with impaired respiratory or hepatic function which mimicked GVH reaction.
Anaphylaxis Due to Cefaclor Hypersensitivity
Authors: Nishioka Kiyoshi , Katayama Ichiro , Kobayashi Yoichi , Takijiri Chincho 
Published: April 2015

AbstractThree cases of anaphylaxis due to cefaclor were reported. All of them developed anaphylactic reactions after exposure to cefaclor by mouth, prick test, or patch testing. Two of them showed crossreactions to other antibiotics. One responded to cephalexin by a prick test and the other responded to cephalexin, ampicillin and talampicillin after patch‐testing of short duration.