bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pentoxifylline Ameliorates Subclinical Atherosclerosis Progression in Patients with Type 2 Diabetes and Chronic Kidney Disease: A Randomized Pilot Trial
Authors: Donate-Correa Javier , Ferri Carla M. , Mora-Fernández Carmen , González-Luis Ainhoa , Navarro-González Juan F. , Pérez-Delgado Nayra 
Published: July 2024

Abstract

Background: Diabetic kidney disease (DKD) is associated with a higher risk of cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase inhibitor with anti-inflammatory, antiproliferative, and antifibrotic actions, has demonstrated renal benefits in both clinical trials and meta-analyses. The present work aimed to study the effects of PTF on the progression of subclinical atherosclerosis (SA) in a population of patients with diabetes and moderate to severe chronic kidney disease (CKD).
Methods: In this open-label, randomized controlled, single-center pilot study the evolution of carotid intima-media thickness (CIMT) and ankle-brachial index (ABI) were determined in 102 patients with type 2 diabetes mellitus and CKD assigned to PTF, aspirin or control groups during 18 months. We also determined the variations in the levels of inflammatory markers and Klotho (KL), a protein involved in maintaining cardiovascular health, and their relationship with the progression of SA.
Results: Patients treated with PTF presented a better evolution of CIMT, increased Klotho levels and reduced the inflammatory state. The progression of CIMT values was inversely related to variations in KL both in serum and mRNA expression levels in peripheral blood cells (PBCs). Multiple regression analysis demonstrated that PTF treatment and variations in mRNA KL expression in PBCs, together with changes in HDL, were significant determinants for the progression of CIMT (adjusted R2= 0.25, P < 0.001) independently of traditional risk factors. Moreover, both variables constituted protective factors against a worst progression of CIMT [OR: 0.105 (P = 0.001) and 0.001 (P = 0.005), respectively].
Conclusions: PTF reduced SA progression assessed by CIMT variation, a beneficial effect related to KL gene expression in PBCs.
Trial registration: The study protocol code is PTF-AA-TR-2009 and the trial was registered on the European Union Drug Regulating Authorities Clinical Trials (EudraCT #2009–016595– 77). The validation date was 2010-03-09.
A Bibliometric Analysis of the Research Trends on Different Philosophical Aspects of Al-Fārābī Between 2000 to 2023
Authors: Davar Mohamad Mahdi , Sadeghi Reyhaneh 
Published: July 2024

Abstract

Background: Al-Fārābī is considered one of the most significant Islamic Philosophers and its founder. He has theorized about various philosophical issues, and as a result of this, he has been the focus of researchers. The aim of this study is to systematically understand the researches done on Fārābī's philosophy.
Method: The bibliometric method of the study is by searching related keywords in the Scopus database, and they limited from 2000 to 2023. Furthermore, after receiving the export from Scopus, these data are analyzed in VOSviewer (version 1.6.20).
Results: Among 302 scientific documents, most of them were articles then book chapters, and most of them were done in English. Since 2015, the research on Fārābī's philosophy has increased, and its peak will be observed in 2020 and 2023. In addition, the United States of America, Kazakhstan, and Iran were the active countries, and according to journals, Arabic Sciences and philosophy and Oriens were the active journals in this field. Chatti, Saloua and Forcada, Miquel were the most active authors according to number of documents, and Adamson, Peter was the first according to citations. In terms of the number of citations, the top ten documents all have more than 25 citations. It should be noted that, the keywords of Al-Fārābī, Al-Farabi, and Avicenna were the bold keywords in studies.
Conclusion: The research on Fārābī's philosophy is limited and requires researchers to examine different aspects of Fārābī's philosophy. In Fārābī's philosophy, issues related to the philosophy of law, political philosophy, peace studies, and even economic philosophy can be extracted.
Zaíta esqueceu de guardar os brinquedos – o percurso de balas pedidas: o diálogo entre a notícia e o conto literário
Authors: Araujo Wagner 
Published: July 2024

Este artigo visa promover reflexões acerca dos elementos intertextuais que dialogam tematicamente e estabelecem influência na construção do projeto ficcional do conto “Zaíta esqueceu de guardar os brinquedos” da autora Conceição Evaristo, advindos do gênero notícia. Para tanto, nos valemos da análise do conto em diálogo com a temática evidenciada nas notícias de jornais circunscritas aos eventos ocasionados por balas perdidas. Por meio de uma abordagem qualitativa e metodologia teórico-analítica-comparativa, objetiva-se propor um modelo de leitura acerca da relação intertextual entre a notícia e o conto literário, considerando seus aspectos convergentes (unidade, meio de veiculação de origem) e divergentes no que se refere à ordem, objetividade e linguagem usada no modo de retratar a realidade e discutir, por meio do diálogo entre os gêneros textuais, aspectos que mobilizaram uma escrita voltada ao universo infantil e de inocência no contexto violento da periferia.
LER É PODER:
Authors: Maria dos Santos Rosana 
Published: July 2024

O artigo tem como objetivo analisar e problematizar a criação do Departamento de Documentação e Cultura e a sua importância para o desenvolvimento das políticas públicas voltadas para as construções de Bibliotecas Populares na cidade do Recife. Em 1949, foi promulgada pelo presidente da Câmara Municipal do Recife e autorizada pelo prefeito Pelópídas Silveira a Lei n° 292, de 16 de abril, que instituía a criação de bibliotecas populares nos bairros da periferia da capital de Pernambuco. As políticas culturais e educacionais propiciadas pela efetivação da Lei impactaram as vidas daqueles que delas puderam ter acesso à leitura. Os benefícios trazidos por essas bibliotecas revelaram uma dimensão antes nunca vista no cenário cultural e educacional do Recife. As bibliotecas populares romperam com o imobilismo da Biblioteca Pública e conseguiram levar a leitura à população mais distante do centro, além disso, proporcionaram o crescimento intelectual do povo marginalizado. As implementações das políticas públicas voltadas ao acesso à educação através da cultura oportunizaram aos moradores do Recife um encontro com a própria identidade de ser humano. Esses espaços de leitura e compartilhamento de conhecimento foram uma inovação, pois proporcionaram o encontro do povo com o livro. Até o final do século XIX essas pessoas sequer poderiam usufruir dos bens públicos de uso comum do povo, como as praças, parques, cujo ingresso era limitado por grades, de sorte que apenas os privilegiados poderiam deles apropriar-se. No entanto, essa apropriação literária proporcionada ao povo foi definida e controlada pelo Estado, através das elites intelectuais do Recife.
Safety and Efficacy of Paxlovid in Pediatric Intensive Care Unit Patients with COVID-19
Authors: Fan Panpan , Ming Meixiu , Liu Tingyan , Chen Weiming , Wang Yixue , Wang Dan , Lu Guoping , Yan Gangfeng 
Published: July 2024

Introduction:
Paxlovid (nirmatrelvir/ritonavir) has received endorsement
from several guidelines for treating COVID-19 in adults, but its use in children is still
uncertain.

Objectives:
This study aimed to evaluate the safety and effectiveness of paxlovid in pediatric
patients in the pediatric intensive care unit (PICU).

Methods:
A retrospective analysis was performed on children with COVID-19. The children
who received paxlovid comprised the paxlovid group; otherwise, they were referred
to as the control group.

Results:
A total of 31 children were enrolled, with 12 and 19 participants assigned to the
paxlovid and control groups, respectively. Approximately 35% had received vaccination
against the novel coronavirus. The control group exhibited a significantly lower mean
age in comparison to the paxlovid group (p < 0.001). However, no significant differences
were observed between the groups in terms of other baseline data and biochemical
indexes at admission. However, on the fifth day of drug administration, the paxlovid
group exhibited a statistically significant decrease in temperature compared to the control
group (p < 0.05). Additionally, the paxlovid group exhibited a significantly shorter
conversion time to negativity for novel coronary genes in the respiratory tract (9.5 days)
compared to the control group (16 days, p < 0.05). The administration of paxlovid did
not result in any observed adverse reactions. Merely two patients exhibited a transient elevation
in liver enzyme levels.

Conclusion:
The application of paxlovid in critically ill pediatric patients with
COVID-19 can effectively control symptoms and promote virus clearance, demonstrating
efficacy and a relatively low-risk profile.
Correlation between Serum 25 (OH) D Levels with Insulin Resistance and Metabolic Associated Fatty Liver Disease - A Retrospective Study based on Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus
Authors: Zhao Xin , Sun Jianbin , Xin Sixu , Xu Xiumei , Zhang Xiaomei 
Published: July 2024

Aims:
The objective of this study was to investigate the correlation between serum 25
hydroxyvitamin D [25(OH)D] levels and insulin resistance, as well as metabolic associated fatty
liver disease (MAFLD) in newly diagnosed with type 2 diabetes mellitus(T2DM) patients.

Method:
A retrospective analysis was conducted on 491 T2DM patients who were newly diagnosed
between January 2017 and August 2022 at Peking University International Hospital. These
patients were categorized into three groups based on their 25(OH)D levels.

Results:
The prevalence of MAFLD was significantly elevated in both the Vitamin D (VD) deficiency group and the VD insufficiency group compared to the VD sufficiency group (χ2 = 6.51, p<0.05). The patients in the VD sufficiency group had lower levels of insulin resistance, as assessed by the homeostasis model assessment when compared to the VD deficiency group and the VD insufficiency group (F = 8.61, p<0.05). Additionally, the VD sufficiency group demonstrated higher levels of β cell function in comparison to the other two groups (p<0.05, respectively).

:
A significant negative correlation was observed between 25(OH)D levels and insulin resistance, as assessed by the homeostasis model assessment in T2DM patients(r=-0.33, p<0.05 for females; r=-0.32, p<0.05 for males).

:
In male patients, 25(OH)D was identified as a protective factor against MAFLD(OR = 0.42;95%CI:0.19-0.95;p <0.05). Meanwhile, in female patients, 25(OH)D was also associated with a reduced risk of MAFLD(OR = 0.35;95%CI 0.17-0.89; p<0.05). Additionally, the study determined that the threshold values for 25(OH)D were 15.06 ng/ml in female patients and 18.79 ng/ml in male patients for predicting MAFLD.

Conclusion:
In newly diagnosed with T2DM patients, the level of 25(OH)D may be related to
insulin resistance and β cell secretion function independently and VD deficiency is an independent
risk factor for MAFLD in patients with newly diagnosed T2DM.
Comprehensive Classification of the Capitellar Injury Concurrent with Radial Head Fracture
Authors: Liu Huli , Xie Qianyun , Zhang Yang , Yang Ying , Jiang Yan , Tang Wen , Song Sheng 
Published: July 2024

Background:
Capitellar injury (CI) includes capitellar cartilage injury (CCI) and capitellar fracture (CF). A comprehensive classification of CI concurrent with
radial head fracture (RHF) that can guide surgical strategy is lacking in the literature. Therefore, this study aimed to introduce a comprehensive
classification of CI concurrent with RHF and investigate its value.

Methods:
A total of 35 patients with CI concurrent with RHF confirmed by surgical exploration were retrospectively analyzed, includingmales in 19 cases
and females in 16 cases. RHF was classified according to the Mason classification, and CI was classified into six types, including 3 types of CCI
and CF, each based on the site and degrees of injuries (comprehensive classification method proposed in this study). The classification results were
analyzed. Two radiologists were selected to independently classify the CI, and the inter- and intra-observer agreements were analyzed with kappa
statistics.

Results:
Mason Type I, II, III, and IV RHF accounted for 14.3%, 48.6%, 37.1%, and 0% of cases, respectively. Type I, II, III, IV, V, and VI CIs accounted
for 22.9%, 34.3%, 25.7%, 11.4%, 2.9%, and 2.9% of cases, respectively. Therewas no obvious relationship between the CI and RHF types (p >
0.05). All Type I CIs underwent removal, 9 Type II CIs underwent microfracture repair, and 3 Type II CIs underwent removal. All Type III CIs
underwent fixation, one Type IV CI underwent removal, and 3 Type IV CIs underwent fixation, one Type V CI underwent fixation, and one Type
VI CI underwent arthroplasty. The inter- and intra-observer kappa coefficients were 0.830 ~ 0.905 and 0.805 ~ 0.892, respectively. At 12 months
postoperatively, the elbow function evaluated by MEPS was 91, with an excellent and good rate of 97%.

Conclusion:
Different types of CI differ not only in pathology but also in treatment methods. The CI comprehensive classification put forth in this paper for the
first time reflects different types of pathology well, with high consistency and repeatability, and can guide the selection of surgical methods,
leading to satisfactory postoperative results.
Fast Determination of Fat-soluble Vitamins in Pharmaceutical Preparations by High-Performance Liquid Chromatography
Authors: Kızılcay Gamze Ergin , Andac Sena Caglar , Toker Sıdıka Erturk 
Published: July 2024

Background:
Vitamins are needed for the healthy functioning of the body. When these
vitamins are not in sufficient amounts in the body, they are usually taken externally with
pharmaceutical preparations. Taking vitamins into the body in the right amounts is possible by
analyzing the amounts in pharmaceutical preparations with validated methods.

Methods:
In this study, a fast, simple, easily applicable, and selective normal-phase HPLC method
was developed for the simultaneous determination of fat-soluble A, D3, E, and K1 vitamins in
pharmaceutical preparations from syrup and tablets. Separation of the vitamins was carried out on a
Zorbax CN column (250 x 4.6 mm, 5 µm) using a mixture of hexane-isopropyl alcohol (98:2, v/v) at
30°C column temperature and 1 ml/min flow rate. The detection wavelength is 280 nm. The
developed method has been validated according to ICH Harmonised Tripartite Guideline Validation
of Analytical Procedures: Text and Methodology Q2(R1) rules.

Results:
Calibration graphs are linear over the range of 10-1000 μg ml-1, 1-50 μg ml-1, 10-2000 μg
ml-1, 0.5-20 μg ml-1, and the limit of detection values were found to be 1.496, 0.280, 1.388 and 0.040
μg ml-1 for A, D3, E and K1 vitamins, respectively. Relative standard deviation values, which express
within-day and between-day repeatability, were found below 2.54%. Average recovery values were
also found at about 100.28, 101.46, 100.65, and 100.29% for A, D3, E, and K1 vitamins, respectively.

Conclusion:
The developed and validated method was successfully applied to the simultaneous
analysis of fat-soluble vitamins A, D3, E, and K1 in pharmaceutical preparations in syrup and tablet
form.
Mucoepidermoid Carcinoma of the Thyroglossal Duct: Two Rare Entities
in a Unique Case Report
Authors: Di Dato Carla , Senes Paola , Barnabei Agnese , Caruso Gianluca , Gomes Vito Vincenzo , Scoppola Alessandro 
Published: July 2024

Background::
Mucoepidermoid Carcinoma (MEC) of the thyroid represents less than
0.5% of all thyroid neoplasms. Thyroglossal duct cyst carcinoma is a rare condition with only
approximately 300 cases reported.

Case Report::
A 34-year-old pregnant woman at 37 weeks gestation presented to an endocrinological
center for primary autoimmune hypothyroidism. The thyroid ultrasound revealed a
pseudonodular pattern. The patient was followed up after two years. She reported a full-term
delivery without complications. A new thyroid ultrasound was performed, showing a cystic lesion
in the median suprathyroid area, measuring 6 x 9 x 10 mm, not previously reported. After 4
months, the suprathyroid cystic lesion was confirmed by thyroid ultrasound, measuring 6 x 11 x
12 mm. The patient was referred for fine-needle aspiration cytology. Cytological examination
showed lymphocytes, red blood cells, and some epithelial aggregates with large cytoplasm and
nuclear polymetrism with oxyphilic aspects. The patient underwent the Sistrunk procedure for
the suprathyroid lesion. The histological examination revealed lymphocytic thyroiditis in
heterotopic thyroid tissue with solid cell nest, epidermoid epithelium, and mucus-secreting cells
suggestive of low-grade mucoepidermoid carcinoma. The immunohistochemistry study was
positive, exhibiting thyroid transcription factor 1 and cytokeratin-19. No positivity was observed
for thyroglobulin, calcitonin, galectin-3, and Hector Battifora mesothelial antigen 1. The
recent follow-up examination, 13 months after the surgery, has been found negative for disease
recurrence.

Conclusion::
This is the first case of an MEC occurring within a thyroglossal duct. Considering
the age of the patient, the histological diagnosis, and the absence of thyroid nodules and metastasis,
we decided on the Sistrunk procedure without total thyroidectomy.
Eudaimonic Well-Being as a Moderator of the Relationship between Depressive Symptoms and Life Satisfaction
Authors: Joshanloo Mohsen 
Published: July 2024

Aim
This study aimed to investigate the potential protective role of eudaimonic well-being in mitigating the adverse effects of depressive symptoms.

Background
The dual continua model conceptualizes mental well-being and mental illness as related yet independent dimensions. According to this framework, well-being can serve as an active defense against mental illness.

Objective
Building on the dual continua model, the study aimed to investigate the relationship between depressive symptoms and life satisfaction and the potential moderating role of eudaimonic well-being.

Methods
This hypothesis was tested using a national sample of 17,357 people from 8,162 households in South Korea. Bayesian multi-level modeling was used for data analysis.

Results
The results showed that eudaimonic well-being moderated the relationship between depressive symptoms and life satisfaction. Depressive symptoms were found to have a significant negative effect on life satisfaction in individuals with low and moderate eudaimonic well-being. However, in individuals with high eudaimonic well-being, depressive symptoms had no significant effect on life satisfaction.

Conclusion
These results suggest that eudaimonic well-being plays an important role in mitigating the effects of depressive symptoms on life satisfaction.
PERUBAHAN GUNA LAHAN DI SEKITAR PINTU TOL MADYOPURO
Authors: Fisara Dennizza Arsya , Rahmawati Turniningtyas Ayu , Wijaya I Nyoman Suluh 
Published: July 2024

Pembangunan Jalan Tol Malang-Pandaan secara langsung maupun tidak akan menimbulkan dampak terhadap lingkungan seperti pergeseran penggunaan lahan terutama di sekitar Pintu Tol Madyopuro. Penelitian ini menganalisis perubahan guna lahan setelah adanya pembangunan jalan tol dengan menggunakan analisis overlay, keterkaitan perubahan guna lahan dengan perubahan harga lahan dengan menggunakan analisis korelasi, dan menganalisis faktor yang mempengaruhi perubahan guna lahan di sekitar Pintu Tol Madyopuro dengan menggunakan analisis faktor eksploratori. Perubahan guna lahan yang terjadi sebelum dan sesudah adanya Pintu Tol Madyopuro didominasi oleh penurunan luas ladang sebesar 49,54 hektar atau perubahan sebesar 12,26% dari luas total Kelurahan Madyopuro. Harga lahan pula mengalami kenaikan hingga 156% dari harga lahan sebelum Keterkaitan hubungan perubahan guna lahan yang berbatasan secara langsung dengan Pintu Tol Madyopuro dan harga lahan memiliki nilai korelasi 0,813 yang termasuk kedalam korelasi dengan interval koefisien 0,800-100 dengan klasifikasi sangat tinggi. Selanjutnya, berdasarkan hasil analisis faktor perubahan guna lahan menjadi guna lahan perdagangan dan jasa diketahui bahwa terdapat 7 faktor yang mempengaruhi perubahan guna lahan di sekitar Pintu Tol Madyopuro. Faktor tersebut adalah jarak sarana dari guna lahan, faktor kebijakan, faktor kenyamanan lingkungan, faktor ketersediaan sarana dan prasarana, faktor ekonomi, faktor lokasi guna lahan, dan faktor kerawanan bencana.
Establishment and Evaluation of a Noninvasive Metabolism-Related Fatty Liver Screening and Dynamic Monitoring Model: Cross-Sectional Study
Authors: Ni Jiali , Huang Yong , Xiang Qiangqiang , Zheng Qi , Xu Xiang , Qin Zhiwen , Sheng Guoping , Li Lanjuan 
Published: July 2024

Background
Metabolically associated fatty liver disease (MAFLD) insidiously affects people's health, and many models have been proposed for the evaluation of liver fibrosis. However, there is still a lack of noninvasive and sensitive models to screen MAFLD in high-risk populations.

Objective
The purpose of this study was to explore a new method for early screening of the public and establish a home-based tool for regular self-assessment and monitoring of MAFLD.

Methods
In this cross-sectional study, there were 1758 eligible participants in the training set and 200 eligible participants in the testing set. Routine blood, blood biochemistry, and FibroScan tests were performed, and body composition was analyzed using a body composition instrument. Additionally, we recorded multiple factors including disease-related risk factors, the Forns index score, the hepatic steatosis index (HSI), the triglyceride glucose index, total body water (TBW), body fat mass (BFM), visceral fat area, waist-height ratio (WHtR), and basal metabolic rate. Binary logistic regression analysis was performed to explore the potential anthropometric indicators that have a predictive ability to screen for MAFLD. A new model, named the MAFLD Screening Index (MFSI), was established using binary logistic regression analysis, and BFM, WHtR, and TBW were included. A simple rating table, named the MAFLD Rating Table (MRT), was also established using these indicators.

Results
The performance of the HSI (area under the curve [AUC]=0.873, specificity=76.8%, sensitivity=81.4%), WHtR (AUC=0.866, specificity=79.8%, sensitivity=80.8%), and BFM (AUC=0.842, specificity=76.9%, sensitivity=76.2%) in discriminating between the MAFLD group and non-fatty liver group was evaluated (P<.001). The AUC of the combined model including WHtR, HSI, and BFM values was 0.900 (specificity=81.8%, sensitivity=85.6%; P<.001). The MFSI was established based on better performance at screening MAFLD patients in the training set (AUC=0.896, specificity=83.8%, sensitivity=82.1%) and was confirmed in the testing set (AUC=0.917, specificity=89.8%, sensitivity=84.4%; P<.001).

Conclusions
The novel MFSI model was built using WHtR, BFM, and TBW to screen for early MAFLD. These body parameters can be easily obtained using a body fat scale at home, and the mobile device software can record specific values and perform calculations. MFSI had better performance than other models for early MAFLD screening. The new model showed strong power and stability and shows promise in the area of MAFLD detection and self-assessment. The MRT was a practical tool to assess disease alterations in real time.