bluuebunny/crossref_metadata_2025_split huggingface dataset:
ELP Estimation
Authors: Olsen Thomas 
Published: July 2024

AbstractThe rationale of the “thin-lens” IOL power calculation formula and the definition of the estimated lens plane (ELP) are explained. Because the ELP is often back-calculated from the observed outcome the ELP is different from the physical position of the IOL. The exact manner by which the ELP is predicted varies between the various formulas, which may take the axial length, the K-reading, the anterior chamber depth, the lens thickness, and other parameters to increase the predictability. However, care should be taken when dealing with post-LASIK eyes, keratoconus, or other unusual eyes. Unlike the “thin-lens” ELP-formulas, the Olsen formula utilizes the C-constant concept, predicting the physical position of the IOL from the position and anatomy of the crystalline lens. Finally, an error propagation model is presented predicting the total IOL prediction error as a function of errors in the ELP prediction (largest source), the keratometry, the axial length reading, and other sources of error.
Atemwegssicherung bei Neugeborenen und Säuglingen
Authors: Kaufmann Jost , Huber Dennis , Engelhardt Thomas , Kleine-Brueggeney Maren , Kranke Peter , Riva Thomas , von Ungern-Sternberg Britta S. , Fuchs Alexander 
Published: July 2024

ZusammenfassungDie Sicherung der Atemwege ermöglicht die Oxygenierung und Ventilation der Lungen und stellt eine potenziell lebensrettende medizinische Maßnahme dar. Insbesondere bei Neugeborenen und Säuglingen kommt es gehäuft zu unerwünschten und kritischen Ereignissen während des Atemwegsmanagements. Die multifaktoriellen Gründe dafür umfassen patientenabhängige, anwenderabhängige, aber auch externe Faktoren. Im Folgenden wird die neu erschienene internationale Leitlinie zur Atemwegssicherung bei Neugeborenen und Säuglingen fokussierend auf die klinische Anwendung zusammengefasst. Während die Originalpublikation der Leitlinie darauf fokussiert, auf Basis der systematisch erfassten Evidenz formale Empfehlungen zu benennen, stellt diese Zusammenfassung v. a. die Praktikabilität ihrer Umsetzung in den Fokus.
Effect of low vacuum medium temperature drying on reduction of residual stress and correction of warp of Japanese cedar timber
Authors: Jiang Zhuoting , Yamamoto Hiroyuki , Yoshida Masato , Dohi Motoo , Tanaka Kento , Yamashita Kana , Watanabe Ken 
Published: July 2024

AbstractCryptomeria japonica (Japanese cedar) in Japan plantations are aging, and the main supply of timber in the market is shifting from small- and medium-diameter to large-diameter logs. The effective utilization of these logs has become an important issue in the timber industry. When producing timber-without-pith from large-diameter logs, an unavoidable warp occurs because of the release of residual stress within the logs. Utilizing high-temperature drying with a load on these timbers has achieved significant drying effects, and the residual stress-induced warp was corrected. However, high-temperature drying has drawbacks, such as high energy consumption and the potential for thermal degradation. We applied low-vacuum-medium-temperature drying (LVMT-drying, 10 days, 40 kPa, 80/55 °C (DB/WB)—90/65 °C (DB/WB)) with load (650 kgf/m2) to the stacked timber sawn from large-diameter logs to address these questions. When LVMT-drying was successful, residual stresses in timber-with-pith were reduced to nearly zero, and warps in timber-without-pith were reduced to less than 8 mm, i.e., below the Japan Agriculture Standard "Level 1" for 4000 mm timber, and the acceptance rate for "Level 1" increased from 45% (green timber) to 85% (treated timber) in the most successful sample. LVMT-drying is a practical drying method for timber from large-diameter logs because it is effective in reducing residual stress and correcting warps while shortening the treatment period and avoiding thermal degradation.
A new spherical harmonic approach to residual terrain modeling: a case study in the central European Alps
Authors: Schwabe Joachim , Mayer-Gürr Torsten , Hirt Christian , Bauer Tobias 
Published: July 2024

AbstractFor decades, the residual terrain model (RTM) concept (Forsberg and Tscherning in J Geophys Res Solid Earth 86(B9):7843–7854,https://doi.org/10.1029/JB086iB09p07843, 1981) has been widely used in regional quasigeoid modeling. In the commonly used remove-compute-restore (RCR) framework, RTM provides a topographic reduction commensurate with the spectral resolution of global geopotential models. This is usually achieved by utilizing a long-wavelength (smooth) topography model known as reference topography. For computation points in valleys this neccessitates a harmonic correction (HC) which has been treated in several publications, but mainly with focus on gravity. The HC for the height anomaly only recently attracted more attention, and so far its relevance has yet to be shown also empirically in a regional case study. In this paper, the residual spherical-harmonic topographic potential (RSHTP) approach is introduced as a new technique and compared with the classic RTM. Both techniques are applied to a test region in the central European Alps including validation of the quasigeoid solutions against ground-truthing data. Hence, the practical feasibility and benefits for quasigeoid computations with the RCR technique are demonstrated. Most notably, the RSHTP avoids explicit HC in the first place, and spectral consistency of the residual topographic potential with global geopotential models is inherently achieved. Although one could conclude that thereby the problem of the HC is finally solved, there remain practical reasons for the classic RTM reduction with HC. In this regard, both intra-method comparison and ground-truthing with GNSS/leveling data confirms that the classic RTM (Forsberg and Tscherning 1981; Forsberg in A study of terrain reductions, density anomalies and geophysical inversion methods in gravity field modeling. Report 355, Department of Geodetic Sciences and Surveying, Ohio State University, Columbus, Ohio, USA,https://earthsciences.osu.edu/sites/earthsciences.osu.edu/files/report-355.pdf, 1984) provides reasonable results also for a high-resolution (degree 2160) RTM, yet neglecting the HC for the height anomaly leads to a systematic bias in deep valleys of up to 10–20 cm.
R2-ISS staging combined with circulating plasma cells improves risk stratification for newly diagnosed multiple myeloma: a single-center real-world study
Authors: Chu Bin , Wang Yu-tong , Gao Shan , Shi Lei , Lu Min-qiu , Fang Li-juan , Xiang Qiu-qing , Chen Yuan , Wang Meng-zhen , Wang Li-fang , Sun Kai , Yang Jing , Duan Fangfang , Bao Li 
Published: July 2024

AbstractWe aimed to evaluate if circulating plasma cells (CPC) detected by flow cytometry could add prognostic value of R2-ISS staging. We collected the electronic medical records of 336 newly diagnosed MM patients (NDMM) in our hospital from January 2017 to June 2023. The median overall survival (OS) for patients and R2-ISS stage I-IV were not reached (NR), NR, 58 months and 53 months, respectively. There was no significant difference in OS between patients with stage I and patients with stage II (P = 0.309) or between patients with stage III and patients with stage IV (P = 0.391). All the cases were re-classified according to R2-ISS stage and CPC numbers ≥ 0.05% (CPC high) or<0.05% (CPC low) into four new risk groups: Group 1: R2-ISS stage I + R2-ISS stage II and CPC low, Group 2: R2-ISS stage II and CPC high + R2-ISS stage III and CPC low, Group 3: R2-ISS stage III and CPC high + R2-ISS stage IV and CPC low, Group 4: R2-ISS stage IV and CPC high. The median OS were NR, NR, 57 months and 32 months. OS of Group 1 was significantly longer than that of Group 2 (P = 0.033). OS in Group 2 was significantly longer than that of Group 3 (P = 0.007). OS in Group 3 was significantly longer than that of Group 4 (P = 0.041). R2-ISS staging combined with CPC can improve risk stratification for NDMM patients.
Facile route for processing natural polymers for the formulation of new low-cost hydrophobic protective hybrid coatings for carbon steel in petroleum industry
Authors: Fetouh H. A. 
Published: July 2024

AbstractThis research helps with the creation, assessment, and characterization of a new hybrid protective coating for carbon steel alloy in acid conditions. The findings of this study will be useful for both chemical and petrochemical companies as well as scientists. This study aims to protect C-steel in acid pickling solution 1.0M HCl and formulate new hydrophobic protective hybrid organic–inorganic coatings from biopolymers chitosan and plant resin guar gum. Eight coating samples of chitosan in the absence and the presence of guar gum, silica and two heterocyclic compounds are prepared at feasible operational conditions using hot melt method. The aiding additives improved compatibility between coating constituents as confirmed by using different methods of analysis. This new processing approach has addressed the problems of using chitosan in corrosion control such as solubility in acid media and low mechanical strength. Coating samples of chitosan and its composites with the heterocyclic compounds (2-Hydrazinyl-6-methyl-4, 5-dihydro pyrimidine-4-on) or (2-Hydrazinyl-6-phenyl-4, 5-dihydro pyrimidine-4-on) are potent biocides. Coating shifts corrosion potential of carbon steel by 30 mV to more noble direction relative to the active potential 520 mV of bare carbon steel surface. Impedance and polarization measurements indicate that coating samples protect metal surface as mixed-type inhibitor by adsorption mechanism. There is a good agreement between percentages protection %P of coating calculated using the values of charge transfer resistance, Rct, and corrosion current density, icorr. All %P values are above 99% for all coating samples. Guar gum plant resin increases gloss of the coating film. Silica fills the pores in the polymeric film and increases the stuffiness of the polymeric coating film by modifying the particle size. All coated samples have high contact angle ranging from 150° to 165° indicating low wettability and high hydrophobicity of coating film on the metal surface.
Cervicothoracic ventral-dorsal rhizotomy for treatment of brachial hypertonia in cerebral palsy
Authors: Abdelmageed Sunny , Dalmage Mahalia , Mossner James M. , Trierweiler Robin , Krater Tim , Raskin Jeffrey S. 
Published: July 2024

Abstract
Purpose
Cervicothoracic ventral-dorsal rhizotomy (VDR) is a potential treatment of medically refractory hypertonia in patients who are not candidates for intrathecal baclofen, particularly in cases of severe upper limb hypertonia with limited to no function. A longitudinal cohort was identified to highlight our institutional safety and efficacy using cervicothoracic VDR for the treatment of hypertonia.

Methods
Retrospective data analysis was performed for patients that underwent non-selective cervicothoracic VDR between 2022 and 2023. Non-modifiable risk factors, clinical variables, and operative characteristics were collected.

Results
Six patients (three female) were included. Four patients underwent a bilateral C6-T1 VDR, one patient underwent a left C7-T1 VDR, and another underwent a left C6-T1 VDR. Three patients had quadriplegic mixed hypertonia, one patient had quadriplegic spasticity, one patient had triplegic mixed hypertonia, and one patient had mixed hemiplegic hypertonia. The mean difference of proximal upper extremity modified Ashworth scale (mAS) was − 1.4 ± 0.55 (p = 0.002), and − 2.2 ± 0.45 (p < 0.001) for the distal upper extremity. Both patients with independence noted quality of life improvements as well as increased ease with dressing and orthotics fits. Caregivers for the remaining four patients noted improvements in caregiving provision, mainly in dressing, orthotics fit, and ease when transferring.

Conclusion
Cervicothoracic VDR is safe and provides tone control and quality of life improvements in short-term follow-up. It can be considered for the treatment of refractory hypertonia. Larger multicenter studies with longer follow-up are necessary to further determine safety along with long-term functional benefits in these patients.
Atmospheric nitrogen dioxide suppresses the activity of phytochrome interacting factor 4 to suppress hypocotyl elongation
Authors: Takahashi Misa , Sakamoto Atsushi , Morikawa Hiromichi 
Published: July 2024

Abstract
Main conclusion
Ambient concentrations of atmospheric nitrogen dioxide (NO2) inhibit the binding of PIF4 to promoter regions of auxin pathway genes to suppress hypocotyl elongation in Arabidopsis.

Abstract
Ambient concentrations (10–50 ppb) of atmospheric nitrogen dioxide (NO2) positively regulate plant growth to the extent that organ size and shoot biomass can nearly double in various species, including Arabidopsis thaliana (Arabidopsis). However, the precise molecular mechanism underlying NO2-mediated processes in plants, and the involvement of specific molecules in these processes, remain unknown. We measured hypocotyl elongation and the transcript levels of PIF4, encoding a bHLH transcription factor, and its target genes in wild-type (WT) and various pif mutants grown in the presence or absence of 50 ppb NO2. Chromatin immunoprecipitation assays were performed to quantify binding of PIF4 to the promoter regions of its target genes. NO2 suppressed hypocotyl elongation in WT plants, but not in the pifq or pif4 mutants. NO2 suppressed the expression of target genes of PIF4, but did not affect the transcript level of the PIF4 gene itself or the level of PIF4 protein. NO2 inhibited the binding of PIF4 to the promoter regions of two of its target genes, SAUR46 and SAUR67. In conclusion, NO2 inhibits the binding of PIF4 to the promoter regions of genes involved in the auxin pathway to suppress hypocotyl elongation in Arabidopsis. Consequently, PIF4 emerges as a pivotal participant in this regulatory process. This study has further clarified the intricate regulatory mechanisms governing plant responses to environmental pollutants, thereby advancing our understanding of how plants adapt to changing atmospheric conditions.
Sleep disturbances in hospitalized children: a wake-up call
Authors: Burger Pia , Steur Lindsay M.H. , Polderman Jorinde A.W. , Twisk Jos W.R. , Lindeboom Robert , Gemke Reinoud J.B.J. 
Published: July 2024

AbstractAlthough sleep is essential for (recovery of) health, it is adversely affected by hospitalization, due to disease discomfort, environmental noise, and care routines, causing reduced sleep and increased disturbances. This study evaluates factors affecting sleep quality and quantity in hospitalized children and compares inpatient sleep with sleep at home. Using an observational, prospective study design, we assessed sleep in hospitalized children aged 1–12 years, admitted to a tertiary center, and compared this with home 6–8 weeks after discharge. We measured total sleep time (TST), sleep onset latency (SOL), wake after sleep onset (WASO), sleep efficiency, awakenings, and subjective sleep quality, using actigraphy, sleep diaries, and PROMIS questionnaires. We explored an array of sleep-disturbing factors. Regression analyses identified key determinants affecting sleep patterns, while mixed linear models compared sleep in hospital to sleep at home. Out of 621 eligible patients, 467 were invited, and 272 (58%) consented to participate. Key determinants of sleep included pain, number of previous admissions, (underlying) chronic illness, and environment-, staff-, and disease-related factors. Parents reported lower perceived sleep quality in the hospital compared to at home, 97-min (SE 9) lower TST, 100-min (5) longer WASO, more difficulties with falling asleep, lower sleep satisfaction, and more awakenings. Actigraphy outcomes revealed shorter TST (20 min (6)), but better sleep efficiency and fewer awakenings in the hospital.
Conclusion: Sleep in hospital was compromised in comparison to sleep at home, primarily due to disturbances related to treatment, environment, and staff. These findings underscore the necessity and potential of relative simple interventions to improve sleep quality and minimize sleep disturbances in hospitalized children.
Tamoxifen may contribute to preserve cardiac function in Duchenne muscular dystrophy
Authors: Henzi Bettina C. , Lava Sebastiano A. G. , Spagnuolo Carlos , Putananickal Niveditha , Donner Birgit C. , Pfluger Marc , Burkhardt Barbara , Fischer Dirk 
Published: July 2024

AbstractDuchenne muscular dystrophy is life-limiting. Cardiomyopathy, which mostly ensues in the second decade of life, is the main cause of death. Treatment options are still limited. The TAMDMD (NCT03354039) trial assessed motor function, muscle strength and structure, laboratory biomarkers, and safety in 79 ambulant boys with genetically confirmed Duchenne muscular dystrophy, 6.5–12 years of age, receiving either daily tamoxifen 20 mg or placebo for 48 weeks. In this post-hoc analysis, available echocardiographic data of ambulant patients recruited at one study centre were retrieved and compared before and after treatment. Data from 14 patients, median 11 (interquartile range, IQR, 11–12) years of age was available. Baseline demographic characteristics were similar in participants assigned to placebo (n = 7) or tamoxifen (n = 7). Left ventricular end-diastolic diameter in the placebo group (median and IQR) was 39 (38–41) mm at baseline and 43 (38–44) mm at study end, while it was 44 (41–46) mm at baseline and 41 (37–46) mm after treatment in the tamoxifen group. Left ventricular fractional shortening in the placebo group was 35% (32–38%) before and 33% (32–36%) after treatment, while in the tamoxifen group it was 34% (33–34%) at baseline and 35% (33–35%) at study end. No safety signals were detected.Conclusion: This hypothesis-generating post-hoc analysis suggests that tamoxifen over 48 weeks is well tolerated and may help preserving cardiac structure and function in Duchenne muscular dystrophy. Further studies are justified.ClinicalTrials.gov Identifier: EudraCT 2017–004554–42, NCT03354039

What is known:• Duchenne muscular dystrophy (DMD) is life-limiting. Cardiomyopathy ensues in the second decade of life and is the main cause of death. Treatment options are still limited.• Tamoxifen reduced cardiac fibrosis in mice and improved cardiomyocyte function in human-induced pluripotent stem cell-derived cardiomyocytes.

What is new:• In this post-hoc analysis of the TAMDMD trial among 14 boys, median 11 years of age, treated with either tamoxifen or placebo for 48 weeks, treatment was well-tolerated.• A visual trend of improved left-ventricular dimensions and better systolic function preservation generates the hypothesis of a potential beneficial effect of tamoxifen in DMD cardiomyopathy.
Extrauterine growth restriction in very-low-birthweight infants: prevalence and concordance according to Fenton, Olsen, and INTERGROWTH-21st growth charts in a multicenter Spanish cohort
Authors: González López Clara , Solís Sánchez Gonzalo , Fernández Colomer Belén , Mantecón Fernández Laura , Lareu Vidal Sonia , Arias Llorente Rosa Patricia , Ibáñez Fernández Aleida , González García Lara Gloria , Suárez Rodríguez Marta 
Published: July 2024

AbstractMultiple criteria and growth references have been proposed for extrauterine growth restriction (EUGR). We hypothesized that these may impact the diagnosis of EUGR. The objective was to evaluate the prevalence of EUGR with its different definitions and the concordance according to Fenton, Olsen, and INTERGROWTH-21st in very-low-birthweight (VLBW) infants. This is an observational, retrospective, and multicenter study including VLBW infants from the Spanish SEN1500 Network from 2011 to 2020. Patients with major congenital anomalies, embryopathies, and gestational age less than 24 weeks were excluded. EUGR prevalence was calculated at discharge with cross-sectional, longitudinal, “true” cross-sectional, and “true” longitudinal definitions. Concordance was assessed with Fleiss’ kappa coefficient. 23582 VLBW infants from 77 NICUs were included. In total, 50.4% were men with a median of gestational age of 29 (4) weeks. The prevalence of EUGR (cross-sectional, longitudinal, and “true”) was variable for weight, length, and head circumference. Overall, the prevalence was higher with Fenton and lower with Olsen (cross-sectional and “true” cross-sectional) and INTERGROWTH-21st (longitudinal and “true” longitudinal). Agreement among the charts by weight was good only for cross-sectional EUGR and moderate for longitudinal, “true” cross-sectional, and “true” longitudinal. Concordance was good or very good for EUGR by length and head circumference.Conclusions: The prevalence of EUGR with the most commonly used definitions was variable in the cohort. Agreement among growth charts was moderate for all the definitions of EUGR by weight except cross-sectional and good or very good for length and head circumference. The choice of reference chart can impact the establishment of the diagnosis of EUGR.

What is known:• EUGR has been defined in the literature and daily practice considering weight, length and head circumference with multiple criteria (cross-sectional, longitudinal, and “true” definition)• Different growth charts have been used for EUGR diagnosis

What is new:• Prevalence of EUGR is variable depending on the definition and growth chart used in our cohort of VLBW infants• For the most frequently EUGR criteria used, traditionally considering weight, concordance among Fenton, Olsen and INTERGROWTH-21st growth charts is only moderate for all the definitions of EUGR by weight except cross-sectional definition. Concordance among the charts is good or very good for the different criteria of EUGR by head circumference and length
Warfarin-related nephropathy: unveiling the hidden dangers of anticoagulation
Authors: Xu Fengbo , Wang Guoqin , Sun Lijun , Cheng Hong 
Published: July 2024

AbstractWarfarin-related nephropathy (WRN) is defined as acute kidney injury subsequent to excessive anticoagulation with warfarin. Patients with mechanical prosthetic valves require long-term anticoagulant therapy. Nonetheless, warfarin remains the sole available option for anticoagulant therapy. Consequently, patients with mechanical prosthetic valves constitute a special group among the entire anticoagulant population. The present study recorded two cases of patients who had undergone mechanical prosthetic valve surgery and were receiving warfarin therapy. They presented to the hospital with gross hematuria and progressive creatinine levels. Notably, their international normalized ratio (INR) did not exceed three. Subsequent renal biopsies confirmed WRN with IgA nephropathy. The two patients continued to receive warfarin as anticoagulation therapy and were prescribed oral corticosteroids and cyclophosphamide, which resulted in improved renal function during the follow-up. Based on a review of all relevant literature and the present study, we proposed a new challenge: must elevated INR levels be one of the criteria for clinical diagnosis of WRN? Perhaps some inspiration can be drawn from the present article.