bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Evaluation of Achalasia: From the Whalebone to the Chicago Classification
Authors: Fisichella P. Marco , Jalilvand Anahita , Lebenthal Abraham 
Published: January 2015

AbstractFrom the earliest description of dysphagia relieved by dilatation with a whalebone in 1674 we have witnessed the evolution of esophageal function testing from the conventional manometry to the high‐resolution manometry (HRM) and esophageal topography pressure plotting that have led to the revised Chicago classification for esophageal motility disorders in 2014. The goals of this paper are, therefore, (1) to highlight the historical milestones that have led to the diagnostic definition of achalasia, as we know it today; (2) to describe the evaluation process of patients with suspected achalasia; (3) to describe the diagnostic value of the HRM and the usefulness of the Chicago classification in predicting treatment outcomes. The value of Chicago classification is linked to the ability of the clinician to perform a thorough clinical evaluation to identify and correlate specific clinical phenotypes to specific manometric subtypes and predict treatment outcomes. Chicago classification, however, cannot predict which treatment, pneumatic dilatation, or Heller myotomy, should be selected for those with a specific subtype of achalasia.
Internet gaming disorder, social network disorder and laterality: handedness relates to pathological use of social networks
Authors: Bouna-Pyrrou Polyxeni , Mühle Christiane , Kornhuber Johannes , Lenz Bernd 
Published: January 2015

AbstractThe internet age bears new challenges that include health risks. It is agreed that excessive internet use may reach pathological levels. However, the concept of internet addiction lacks specificity and, therefore, warrants studies on its diagnostic and etiologic classification. This study was conducted to characterize the novel DSM-5 criteria for internet gaming disorder and the adapted criteria for the “social network disorder”. Based on the established association of handedness and substance use disorders, we also explored whether internet use related to laterality. For this study, 3,287 volunteers participated in the online survey and gave particulars concerning their internet use in general, internet gaming and use of social networks, laterality markers (hand, foot, eye, ear, rotational preference in gymnastics, and head turning asymmetry) and health status. Of the participants, 1.1 % fulfilled the criteria for internet gaming disorder, and 1.8 % fulfilled the criteria for social network disorder. The applied criteria were highly correlated with the time spent on the respective internet activities (p < 4 × 10−56). The analyses of comorbidity and working hours support the thresholds of 5/9 criteria and ≥30 h/week spent on the internet for the classification as pathological (p < 5 × 10−2). Moreover, we found that left-handedness related to more affirmed criteria and longer times spent on social networks (p ≤ 4 × 10−2). The provided criteria proved to be user-friendly, comprehensible and well accepted. The results contribute to a better understanding of pathological internet gaming and social network use and provide evidence that biological markers of substance use disorders are involved in internet addiction.
Targeted Prevention of Childhood Anxiety: Engaging Parents in an Underserved Community
Authors: Mian Nicholas D. , Eisenhower Abbey S. , Carter Alice S. 
Published: January 2015

AbstractSelective prevention programs hold the promise of alleviating child anxiety symptoms, decreasing the risk for emotional problems across the lifespan. Such programs have particular public health import for young children of poor, underserved communities. Identifying factors related to parent engagement, and methods to improve engagement, are paramount in the effort to develop anxiety‐focused, community prevention programs. This feasibility study investigated the effect of an enhanced recruitment strategy to maximize parent engagement, as well as factors related to attendance in a single session focused on anxiety prevention. Participants were poor, ethnic minority parents of children aged 11–71 months (n = 256) who completed a survey that assessed anxiety risk according to trauma exposure, child anxiety, or parent anxiety, as well as preferences for preventive services (phase 1). Those meeting risk criteria (n = 101) were invited to a preventive group session (phase 2). Half of parents received enhanced recruitment (ER), which included personalized outreach, matching parent preferences, and community endorsement. Other parents were invited by mail. Chi square analyses indicated that ER was associated with planning to attend (49 vs. 6 % of control). Parents receiving ER were 3.5 times more likely to attend. Higher sociodemographic risk was correlated with higher child anxiety symptoms but not attendance. Results highlight the need for improved strategies for engaging parents in preventive, community‐based interventions.
Community Connectedness, Challenges, and Resilience Among Gay Latino Immigrants
Authors: Gray Nicole N. , Mendelsohn David M. , Omoto Allen M. 
Published: January 2015

AbstractTo date, relatively little psychological research has focused on the experiences of lesbian, gay, bisexual, and transgender (LGBT) Latino/a immigrants to the United States. This qualitative study used face‐to‐face semi‐structured interviews to explore the unique sources of stress, challenges, as well as opportunities and factors related to resilience among 13 gay Latino first‐ and second‐generation immigrants. Iterative coding of interview transcripts revealed four key themes, each of which is illustrated with verbatim quotes: (1) feelings of connectedness to the LGBT community, (2) feelings of connectedness to the Latino/a community, (3) intersectional challenges and strategies, and (4) well‐being, strength, and resilience. As suggested by these themes, gay Latino immigrants have distinct sources of stress and conflict, many of them associated with community memberships, but also draw on unique sources of support and adaptive thoughts and behaviors in facing stressors. Implications for studying risk and resilience factors among stigmatized populations, including LGBT individuals and immigrants, are discussed.
Modern Inhalational Anesthetics for Refractory Status Epilepticus
Authors: Zeiler Frederick A. , Zeiler Kaitlin J. , Teitelbaum Jeanne , Gillman Lawrence M. , West Michael 
Published: January 2015

ABSTRACTBackground: Our goal was to perform a systematic review of the literature on the use of modern inhalational anesthetic agents for refractory status epilepticus and their impact on seizure control. Methods: All articles from MEDLINE, BIOSIS, EMBASE, Global Health, HealthStar, Scopus, Cochrane Library, the International Clinical Trials Registry Platform (inception to March 2014), reference lists of relevant articles, and gray literature were searched. The strength of evidence was adjudicated using both the Oxford and Grading of Recommendation Assessment Development and Education methodology by two independent reviewers. Results: Overall, 19 studies were identified, with 16 manuscripts and 3 meeting abstracts. A total of 46 patients were treated. Adult (n=28) and pediatric patients (n=18) displayed 92.9% and 94.4% seizure control with treatment, respectively. Isoflurane was used in the majority of cases. Hypotension was the only complication described. Conclusions: Oxford level 4, Grading of Recommendation Assessment Development and Education D evidence exists to support the use of isoflurane in refractory status epilepticus to obtain burst suppression. Insufficient data exist to comment on the efficacy of desflurane and xenon at this time.
The risk and protective factors associated with depression and anxiety in a national sample of Irish adolescents
Authors: Dooley B. , Fitzgerald A. , Giollabhui N. M. 
Published: January 2015

ObjectivesThe aim of this study is to examine the risk and protective factors associated with anxiety and depression in a representative sample of Irish adolescents.MethodsData used in this study were drawn from a subset of the My World Survey (MWS). The MWS-Second Level (MWS-SL) subset consists of a randomised sample of 72 schools, with a final sample of 6085 students. Outcome measures were depression and anxiety. Risk and protective factors included measures within the socio-demographic, psychosocial and risk-taking domains.ResultsOne in three adolescents experienced elevated levels of depression and anxiety. Age, gender, maternal education, family composition, parental mental health as well as the experience of racism and bereavement were associated with elevated distress. Psychosocial factors associated with depression and anxiety included optimism, personal competence, life-satisfaction, self-esteem, anger, body dissatisfaction, family competence, maternal and paternal criticism, experiencing the break-up of a romantic relationship, school and peer connectedness as well as the availability of one good adult. Finally, engaging in substance misuse was found to increase the likelihood of anxiety and depression.ConclusionSince factors protecting and putting adolescents at risk of anxiety and depression exist at every level of the adolescent’s ecological system, the study supports a community-based approach to youth mental health.
The propagation of gravity currents in a circular cross-section channel: experiments and theory
Authors: Longo S. , Ungarish M. , Di Federico V. , Chiapponi L. , Maranzoni A. 
Published: January 2015

AbstractHigh-Reynolds number gravity currents (GC) in a horizontal channel with circular/semicircular side walls are investigated by comparing experimental data and shallow-water (SW) theoretical results. We focus attention on a Boussinesq system (salt water in fresh water): the denser fluid, occupying part of the depth or the full depth of the ambient fluid which fills the remaining part of the channel, is initially at rest in a lock separated by a gate from the downstream channel. Upon the rapid removal of the gate (‘dam break’), the denser ‘current’ begins propagating into the downstream channel, while a significant adjustment motion propagates upstream in the lock as a bore or rarefaction wave. Using an experimental channel provided by a tube of 19 cm diameter and up to 615 cm length, which could be filled to various levels, we investigated both full-depth and part-depth releases, considered the various stages of inertial-buoyancy propagation (in particular, the initial ‘slumping’ with constant speed, and the transition to the late self-similar propagation with time to the power $3/4$), and detected the transition to the viscous-buoyancy regime. A first series of tests is focused on the motion in the lock while a second series of tests is focused on the evolution of the downstream current. The speed of propagation of the current in the slumping stage is overpredicted by the theory, by about the same amount (typically 15 %) as observed in the classical flat bottom case. The length of transition to viscous regime turns out to be ${\sim}[\mathit{Re}_{0}(h_{0}/x_{0})]^{{\it\alpha}}$ ($\mathit{Re}_{0}=(g^{\prime }h_{0})^{1/2}h_{0}/{\it\nu}_{c}$ is the initial Reynolds number, $g^{\prime }$ is the reduced gravity, ${\it\nu}_{c}$ is the kinematic viscosity of the denser fluid, $h_{0}$ and $x_{0}$ are the height of the denser current and the length of the lock, respectively), with the theoretical ${\it\alpha}=3/8$ and experimental ${\it\alpha}\approx 0.27$.
The Graetz–Nusselt problem extended to continuum flows with finite slip
Authors: Haase A. Sander , Chapman S. Jonathan , Tsai Peichun Amy , Lohse Detlef , Lammertink Rob G. H. 
Published: January 2015

AbstractGraetz and Nusselt studied heat transfer between a developed laminar fluid flow and a tube at constant wall temperature. Here, we extend the Graetz–Nusselt problem to dense fluid flows with partial wall slip. Its limits correspond to the classical problems for no-slip and no-shear flow. The amount of heat transfer is expressed by the local Nusselt number $\mathit{Nu}_{x}$, which is defined as the ratio of convective to conductive radial heat transfer. In the thermally developing regime, $\mathit{Nu}_{x}$ scales with the ratio of position $\tilde{x}=x/L$ to Graetz number $\mathit{Gz}$, i.e. $\mathit{Nu}_{x}\propto (\tilde{x}/\mathit{Gz})^{-{\it\beta}}$. Here, $L$ is the length of the heated or cooled tube section. The Graetz number $\mathit{Gz}$ corresponds to the ratio of axial advective to radial diffusive heat transport. In the case of no slip, the scaling exponent ${\it\beta}$ equals $1/3$. For no-shear flow, ${\it\beta}=1/2$. The results show that for partial slip, where the ratio of slip length $b$ to tube radius $R$ ranges from zero to infinity, ${\it\beta}$ transitions from $1/3$ to $1/2$ when $10^{-4}<b/R<10^{0}$. For partial slip, ${\it\beta}$ is a function of both position and slip length. The developed Nusselt number $\mathit{Nu}_{\infty }$ for $\tilde{x}/\mathit{Gz}>0.1$ transitions from 3.66 to 5.78, the classical limits, when $10^{-2}<b/R<10^{2}$. A mathematical and physical explanation is provided for the distinct transition points for ${\it\beta}$ and $\mathit{Nu}_{\infty }$.
A clustering coefficient for complete weighted networks
Authors: MCASSEY MICHAEL P. , BIJMA FETSJE 
Published: January 2015

AbstractThe clustering coefficient is typically used as a measure of the prevalence of node clusters in a network. Various definitions for this measure have been proposed for the cases of networks having weighted edges which may or not be directed. However, these techniques consistently assume that only a subset of all possible edges is present in the network, whereas there are weighted networks of interest in which all possible edges are present, that is, complete weighted networks. For this situation, the concept of clustering is redefined, and computational techniques are presented for computing an associated clustering coefficient for complete weighted undirected or directed networks. The performance of this new definition is compared with that of current clustering definitions when extended to complete weighted networks.
Phenolic sulfates as new and highly abundant metabolites in human plasma after ingestion of a mixed berry fruit purée
Authors: Pimpão Rui C. , Ventura M. Rita , Ferreira Ricardo B. , Williamson Gary , Santos Claudia N. 
Published: January 2015

Bioavailability studies are vital to assess the potential impact of bioactive compounds on human health. Although conjugated phenolic metabolites derived from colonic metabolism have been identified in the urine, the quantification and appearance of these compounds in plasma is less well studied. In this regard, it is important to further assess their potential biological activityin vivo. To address this gap, a cross-over intervention study with a mixed fruit purée (blueberry, blackberry, raspberry, strawberry tree fruit and Portuguese crowberry) and a standard polyphenol-free meal was conducted in thirteen volunteers (ten females and three males), who received each test meal once, and plasma metabolites were identified by HPLC–MS/MS. Sulfated compounds were chemically synthesised and used as standards to facilitate quantification. Gallic and caffeic acid conjugates were absorbed rapidly, reaching a maximum concentration between 1 and 2 h. The concentrations of sulfated metabolites resulting from the colonic degradation of more complex polyphenols increased in plasma from 4 h, and pyrogallol sulfate and catechol sulfate reached concentrations ranging from 5 to 20 μmat 6 h. In conclusion, phenolic sulfates reached high concentrations in plasma, as opposed to their undetected parent compounds. These compounds have potential use as biomarkers of polyphenol intake, and their biological activities need to be considered.
Metabolic syndrome risk factors are associated with white rice intake in Korean adolescent girls and boys
Authors: Song SuJin , Young Paik Hee , Song Won O. , Song YoonJu 
Published: January 2015

In the present study, we examined the associations of total carbohydrate intake, dietary glycaemic load (DGL) and white rice intake with metabolic syndrome risk factors by sex in Korean adolescents. For the present cross-sectional study, data from the Fourth Korea National Health and Nutrition Examination Survey (2007–9) were used. A total of 2209 adolescents (n 1164 boys and n 1045 girls) aged 10–18 years with complete anthropometric, biochemical and dietary intake data were included in the study. Dietary intake data were obtained using the 24 h recall method, and total carbohydrate intake, DGL and white rice intake were divided into quartiles by sex. The metabolic syndrome and its risk factors were defined using the International Diabetes Federation criteria for children and adolescents. Fasting insulin levels and insulin resistance were included as the metabolic syndrome risk factors. All statistical analyses considered the complex sampling design effect and appropriate sampling weights. Multivariate linear regression analysis was used to estimate means with their standard errors of the mean for the metabolic syndrome risk factors across the quartiles of total carbohydrate intake, DGL and white rice intake. While high DGL was significantly associated with increased fasting glucose levels in boys, high total carbohydrate intake, DGL and white rice intake were consistently associated with reduced HDL-cholesterol levels in girls. High white rice intake was significantly associated with an increased risk of insulin resistance and the metabolic syndrome in girls but not in boys. Optimising dietary carbohydrate intake with respect to the source or amount is fundamental to preventing and managing metabolic diseases in Asian adolescents.
Molecular analysis of faecal samples from birds to identify potential crop pests and useful biocontrol agents in natural areas
Authors: King R.A. , Symondson W.O.C. , Thomas R.J. 
Published: January 2015

AbstractWild habitats adjoining farmland are potentially valuable sources of natural enemies, but also of pests. Here we tested the utility of birds as ‘sampling devices’, to identify the diversity of prey available to predators and particularly to screen for pests and natural enemies using natural ecosystems as refugia. Here we used PCR to amplify prey DNA from three sympatric songbirds foraging on small invertebrates in Phragmites reedbed ecosystems, namely the Reed Warbler (Acrocephalus scirpaceus), Sedge Warbler (Acrocephalus schoenobaenus) and Cetti's Warbler (Cettia cetti). A recently described general invertebrate primer pair was used for the first time to analyse diets. Amplicons were cloned and sequenced, then identified by reference to the Barcoding of Life Database and to our own sequences obtained from fresh invertebrates. Forty-five distinct prey DNA sequences were obtained from 11 faecal samples, of which 39 could be identified to species or genus. Targeting three warbler species ensured that species-specific differences in prey choice broadened the range of prey taken. Amongst the prey found in reedbeds were major pests (including the tomato moth Lacanobia oleracea) as well as many potentially valuable natural enemies including aphidophagous hoverflies and braconid wasps. Given the mobility of birds, this approach provides a practical way of sampling a whole habitat at once, providing growers with information on possible invasion by locally resident pests and the colonization potential of natural enemies from local natural habitats.
Genetic effects of the critical factors of sugary1 fitness
Authors: DJEMEL A. , ORDÁS B. , HANIFI-MEKLICHE L. , KHELIFI L. , ORDÁS A. , REVILLA P. 
Published: January 2015

SUMMARYThe present study was designed to estimate the effects of the mutant su1 on the genetic regulation of fitness-related traits when introgressed into field maize backgrounds. Estimated genetic effects of agronomic traits in Su1 v. su1 plants were monitored in two separate mean generation designs. The first involved unrelated inbred lines EP42 and A631, while two Corn Belt inbred lines, A619 and A632, were used for the second design. Parents, F1s, F2s and backcrosses were crossed to the su1 inbred P39 as the donor of su1 and the 12 crosses were successively self-pollinated for 5 years. For each cross, Su1 and su1 kernels were evaluated separately in a growth chamber under controlled environmental conditions following a randomized complete block design. In addition, the genotypes were evaluated in field trials in 10 × 10 triple lattice designs during 2010 and 2011 at Pontevedra in north-western Spain; and in 2010 at Algiers, located in the sub-humid North of Algeria. The performance of su1 plants was lower when compared to the Su1 plants for all traits evaluated in both designs and across environments. The estimates of genetic effects of Su1 v. su1 plants were strongly affected by genotype and environment. The results suggest that, depending on specific sweet × field maize interaction, seedling vigour and, particularly, chlorophyll content (CCM) were the most critical traits in determining su1 viability. However, the complexity of the genetic regulation of emergence and the great heterogeneity of environmental conditions in the field evaluation prevent the estimation of the genetic regulation on sugary1 fitness.
A longitudinal study of humpback whales in Irish waters
Authors: Ryan Conor , Whooley Pádraig , Berrow Simon D. , Barnes Colin , Massett Nick , Strietman Wouter J. , Broms Fredrik , Stevick Peter T. , Fernald Thomas W. , Schmidt Christian 
Published: January 2015

Knowledge on the ecology of humpback whales in the eastern North Atlantic is lacking by comparison with most other ocean basins. Humpback whales were historically over-exploited in the region and are still found in low relative abundances. This, coupled with their large range makes them difficult to study. With the aim of informing more effective conservation measures in Ireland, the Irish Whale and Dolphin Group began recording sightings and images suitable for photo-identification of humpback whales from Irish waters in 1999. Validated records submitted by members of the public and data from dedicated surveys were analysed to form a longitudinal study of individually recognizable humpback whales. The distribution, relative abundance and seasonality of humpback whale sighting records are presented, revealing discrete important areas for humpback whales in Irish coastal waters. An annual easterly movement of humpback whales along the southern coast of Ireland is documented, mirroring that of their preferred prey: herring and sprat. Photo-identification images were compared with others collected throughout the North Atlantic (N = 8016), resulting in matches of two individuals between Ireland and Iceland, Norway and the Netherlands but no matches to known breeding grounds (Cape Verde and West Indies). This study demonstrates that combining public records with dedicated survey data is an effective approach to studying low-density, threatened migratory species over temporal and spatial scales that are relevant to conservation and management.