bluuebunny/crossref_metadata_2025_split huggingface dataset:
The expression of lncRNAs EVADR and LUESCC in Colorectal tumor tissues and their association with the CRC risk in an Iranian population
Authors: Ahmadzadeh Mozhgan , shahamiri Kamal , Raeisi Mohammad , jafari Negar , Kalaki Niloufar Sadat 
Published: June 2024

Abstract

Colorectal cancer (CRC) is a prevalent form of cancer that impacts individuals around the world. It is the second most common cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) are a type of regulatory RNA that can impact gene expression. EVADR and LUESCC are tow novel lncRNA specifically expressed in tumors of glandular origin, such as colon.in this study we aimed to investigate the expression of EVADR and LUESCC in Colorectal tumor tissues in Iranian patients. We selected 50 cases of colorectal tumor tissues (FFPE) from individuals with sporadic CRC who were referred from the Pathology Department of Imam Hossein hospital in Tehran, Iran. The study results offer valuable insights into the expression patterns of LUESCC and EVADR lncRNAs in CRC patients. The findings show a significant upregulation of both LUESCC and EVADR lncRNAs in CRC patients compared to normal tissues, with notable fold-change values and statistical significance. The ROC curve analysis further emphasizes the potential diagnostic value of these lncRNAs. Additionally, the differential expression of LUESCC and EVADR lncRNAs in different differentiation groups suggests a potential association between these lncRNAs and CRC tumor grade. The significant increase in expression observed in well, poor, and intermediate differentiation groups compared to normal tissues underscores the potential role of these lncRNAs in CRC progression and aggressiveness. The present study also revealed distinct expression patterns of LUESCC and EVADR lncRNAs in relation to metastasis and fecal occult blood. Overall, these findings shed light on the diagnostic and prognostic potential of LUESCC and EVADR lncRNAs in CRC.
Electrically switchable 2N-channel wave-front control with N cascaded polarization-dependent metasurfaces
Authors: Feng Xue , Ma Zhiyao , Tian Tian , Liao Yuxuan , Li Yongzhuo , Cui Kaiyu , Liu Fang , Sun Hao , Zhang Wei , Huang Yidong 
Published: June 2024

Abstract

Metasurfaces with tunable functionalities are greatly desired for modern optical system and various applications. To increase the operating channels of polarization-multiplexed metasurfaces, we proposed a structure of N cascaded dual-channel metasurfaces to achieve 2N electrically switchable functional channels without intrinsic loss or cross-talk. As proof of principles, we have implemented a 3-layer setup to achieve 8 channels. In success, we have demonstrated two typical functionalities of vortex beam generation with switchable topological charge of l=-3 ~ + 4 or l=-1~ -8, and beam steering with the deflecting direction switchable in an 8×1 line or a 4×2 grid. We believe that our proposal would provide a practical way to significantly increase the scalability and extend the functionality of polarization-multiplexed metasurfaces, which are potential for the applications of LiDAR, glasses-free 3D display, OAM (de)multiplexing, and varifocal meta-lens.
Analysis of Care-seeking Pathway and Factors Influencing Early and Appropriate Care-seeking for Malaria Patients in the Republic of Guinea, 2022-2023
Authors: DIALLO Elhadj Marouf , Plucinski Mateusz M , TRAORE Fatoumata Bintou , CAMARA Bienvenu Salim , LANGLET Alice , DELAMOU Alexandre , DIALLO Ousmane Oumou , GERBAUD Laurent , CAMARA Alioune 
Published: June 2024

Abstract

Aim: This this study was conducted to analyze the diagnostic pathway and the factors associated with early and appropriate care-seeking for malaria patients in the Republic of Guinea.
Methods: A cross-sectional study was carried out between November 2022 - March 2023 among 3300 patients diagnosed of malaria in health facilities in nine health districts. Axel Kroeger’s conceptual framework was used for the design of the questionnaire. Conventional recourse was defined as the use of a healthcare facility or community services, early and appropriate care-seeking was defined as within 24 hours of symptom onset in a conventional recourse, and care pathway the sequence of recourses followed by each patient. Sankey alluvial plots were used to represent patients' diagnostic pathways, and logistic regression to identify factors associated with early and appropriate care-seeking.
Results: 1632 (49.45%) were female and 1132 (34.30%) were under 5 years old, with a mean age of 27.46 months (SD = 16.03). At time of interview, 1337 (40.52%), 1423 (43.12%), 437 (13.85%) of patients were respectively in their first, second and third recourse. A total of 2002 (60.67%) patients had gone to a conventional recourse as a first line. Of all patients, 1757 (53.25%) had sought care within 24 hours and 28.55% had sought early and appropriate care. Individually and as a first intention, self-medication was the main modality with 1214 (37.30%). The health districts of Boffa (Lower Guinea, coastal region) OR = 0.48 95% CI 0.33 – 0.70, Dabola (Upper Guinea, savanna region) OR = 0.43 95% CI 0.30 – 0.63 and Labe (Middle Guinea, mountain region) OR = 0.63 CI 95% 0.43 – 0.91 (p<0.05) were at risk of delaying appropriate care seeking, regarding reference district (Dixinn, Conakry). However, the under 5 years old group OR = 1.55 95% CI 1.30 – 1.85 (p<0.001) and the availability of a stable monthly household income (p<0.001) were positively associated with early and appropriate care seeking.
Conclusion: A low rate of early and appropriate care-seeking was observed. Patients sought care through multiple means, often resulting in a delay adequate management. The results, shows the need to deploy strategies adapted to the needs of communities.
Influence of various cleaning solutions on the geometry, roughness, gloss, hardness, and flexural strength of 3D-printed zirconia
Authors: Cai HongXin , Lee Min-Yong , Jiang Heng Bo , Kwon Jae-Sung 
Published: June 2024

Abstract

Objective:This study aimed to investigate the impact of various cleaning solutions on the geometry, roughness, gloss, hardness, and flexural strength of 3D-printed zirconia.
Methods: Cleaning solutions, including isopropyl alcohol (IPA, 99.9%), ethyl alcohol (EtOH, 99.9%), and tripropylene glycol monomethyl ether (TPM, ≥ 97.5%), were diluted to a concentration of 70% and categorized into six groups: IPA99, EtOH99, TPM97, IPA70, EtOH70, and TPM70. Zirconia discs, printed via digital light processing, were sintered after cleaning. The geometry, roughness, gloss, hardness, and flexural strength were analyzed. Statistical analysis was performed using one-way ANOVA with Tukey’s post hoc test (α < 0.05).
Results: The thickness of TPM70 was the highest. The diameter of TPM70 was significantly larger than that of EtOH99 and IPA70 (α < 0.05). The weight of the TPM groups was significantly higher than that of IPA70 (α < 0.05). The roughness Ra of TPM70 was significantly greater than that of IPA99, EtOH99, and EtOH70 (α < 0.05). The differences between the surface roughness, gloss, and flexural strength values of different groups were not statistically significant (α > 0.05).
Significance: Different cleaning solutions did not affect the surface gloss, hardness, and flexural strength of 3D-printed zirconia. High and low concentrations of the same cleaning solution did not affect the surface gloss, hardness, and flexural strength. IPA70, TPM97, and EtOH can be considered viable post-printing cleaning alternatives to the traditional gold standard, IPA99.
Determination of Glucose Oxidase Activity of Flour Additive by Fluorescence Quenching Method
Authors: Dong Na , Zhang Aiju , Zhang Xiaolin , Dai Xingde , He Fangzhen 
Published: June 2024

Abstract

Glucose oxidase can catalyze the reaction of glucose to produce hydrogen peroxide, and hydrogen peroxide reacts with excess I− anions in dilute sulfuric acid solution to form I3−. The I3− combines with Rhodamine 6G to form association which result in fluorescence quenching. Effect of glucose oxidase on fluorescence of Rhodamine 6G, a new method with high sensitivity and good selectivity for the determination of glucose oxidase activity was established. Under the optimal conditions, the linear range of the method is 1.0×10− 4-1.0×10− 1 U/mL, and the detection limit is 9.0×10− 5 U/mL. This assay was applied to the determination of glucose oxidase activity in the food additives samples with satisfactory results, the recoveries obtained were 95.33%-102.5%.
An Hybridization Method of Clustering Images Using Artificial Ants Model (CLAntIMG)
Authors: Masmoudi Nesrine , Ayadi Manel , Salhi Amina , Almuqren Latifa 
Published: June 2024

Abstract

Image clustering is an unsupervised learning task that primary function is to categorise and extract the image's valuable attributes. Many techniques like data augmentation and normalization or meta-heuristic algorithms like swarm intelligence can be used to improve the clustering performance.
This research proposes an hybrid Ant Colony Optimization (ACO) algorithm, named CLAntIMG, based on the KMeans method to improve image clustering performances grouping structured and unstructured data components. The algorithm takes a distance matrix and an initial pheromone matrix as input and returns the best route found by the KMeans algorithm, representing the centroids of the clusters. This method computes pairwise distance matrices using different metric distances (Euclidean, Manhattan, Chebyshev). In addition, a proposed matrix containing dimensional characteristics with extracted features based on Local Binary Pattern (LBP) is applied to extract features from the images, and the resulting dimensional characteristics. These LBP features provide texture information that can enhance the clustering process by considering both spatial and texture-based dissimilarities between data points.
The efficiency and robustness of the proposed CLAntIMG algorithm compared with other algorithms demonstrate its ability to find optimal cluster assignments even with different initial parameters. The performance of each cluster is evaluated using the Silhouette score, the Calinski-Harabasz index and the normalized mutual information (NMI) leading to promising results, notably with the Chebyshev distance, reaching an NMI of 0.94 on the Iris dataset.
Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells
Authors: Young Kristen S. , Hancock Govinda R. , Fink Emma C. , Zigrossi Alexandra , Flowers Brenna , Cooper David A. , Nguyen V. T. , Martinez Millie C. , Mon K. S. , Bosland M. , Zak D. , Runde A. , Sharifi M. N. , Kastrati I. , Minh David , Kregel Steven , Fanning Sean W. 
Published: June 2024

Abstract

Resistance to endocrine therapies remains a major clinical hurdle in breast cancer. Mutations to estrogen receptor alpha (ERα) arise after continued therapeutic pressure. Next generation selective estrogen receptor modulators and degraders/downregulators (SERMs and SERDs) show clinical efficacy, but responses are often non-durable. A tyrosine to serine point mutation at position 537 in the ERα ligand binding domain (LBD) is among the most common and most pathogenic alteration in this setting. It enables endocrine therapy resistance by superceding intrinsic structural-energetic gatekeepers of ER hormone-dependence, it enhances metastatic burden by enabling neomorphic ER-dependent transcriptional programs, and it resists SERM and SERD inhibiton by reducing their binding affinities and abilities to antagonize transcriptional coregulator binding. However, a subset of SERMs and SERDs can achieve efficacy by adopting poses that force the mutation to engage in a new interaction that favors the therapeutic receptor antagonist conformation. We previously described a chemically unconventional SERM, T6I-29, that demonstrates significant anti-proliferative activities in Y537S ERα breast cancer cells. Here, we use a comprehensive suite of structural-biochemical, in vitro, and in vivo approaches to better T6I-29’s activities in breast cancer cells harboring Y537S ERα. RNA sequencing in cells treated with T6I-29 reveals a neomorphic downregulation of DKK1, a secreted glycoprotein known to play oncogenic roles in other cancers. Importantly, we find that DKK1 is significantly enriched in ER+ breast cancer plasma compared to healthy controls. This study shows how new SERMs and SERDs can identify new therapeutic pathways in endocrine-resistant ER+ breast cancers.
The Associations between Health Literacy and Self-Rated Health: The Mediating Role of Life Style Using the Structural Equation Modeling Approach
Authors: Bagherinia Mansour , Rezaeian Shahab , Shakiba Ebrahim , Maleki Raheleh , Mazhin Abbas Mohammad Karimi , Darvishigilan Hadi , Janatolmakan Maryam , Karami Badriyeh 
Published: June 2024

Abstract

Background: Self-Rated Health is related to reduction of burden of diseases and health outcomes. Various factors affect Self-Rated Health. This study aimed to investigate the mediating role of lifestyle in the relationship between health literacy and Self-Rated Health.
Methods: In this cross-sectional study 495 people aged 18- 65 were participated in 2023. Health literacy questionnaire by Montazeri et al., healthy lifestyle assessment questionnaire of Eshaghi et al, and Self-rated health (SRH) by a question developed by the World Health Organization were used. Structural equation modeling (SEM) was used. Statistical analysis of data was performed using STATA 14.2 software.
Results: Based on the results, a significant total effect of health literacy on self-rated health (β= -0.005, P= 0.001), was identified. Life style (β = -0.004) had a direct effect on self-rated health (p < 0.005). The result from SEM indicated that health literacy exhibited a direct effect on life style (β = 78). In addition, considering that health literacy and lifestyle have a significant relationship with self-rated health, and there is a significant relationship between lifestyle and health literacy, it can be concluded that lifestyle plays a mediating role in the relationship between the two variables of health literacy and self-rated health.
Conclusion: Considering the mediating role of lifestyle in the relationship between health literacy and self-rated health, to improve self-rated health, in addition to paying attention to the role of health literacy, it is necessary to take effective measures to positively change people's lifestyle.
Watt-class CMOS-compatible optical high power amplifier
Authors: Singh Neetesh , Lorenzen Jan , Wang Kai , Gaafar Mahmoud , Sinobad Milan , Francis Henry , Edelmann Marvin , Geiselmann Michael , Herr Tobias , Garcia-Blanco Sonia , Kärtner Franz 
Published: June 2024

Abstract

High power amplifiers are critical components in optical systems spanning from long range optical sensing and optical communication systems to micromachining and medical surgery. Today, integrated photonics with its promise of large reductions in size, weight and cost cannot be used in these applications, due to the lack of on-chip high power amplifiers. Integrated devices severely lack in output power due to their small size which limits energy storage capacity. For the last two decades, large mode area (LMA) technology has played a disruptive role in fiber amplifiers enabling a dramatic increase of output power and energy by orders of magnitude. Thanks to the capability of LMA fiber to support significantly larger optical modes the energy storage and power handling capability has significantly increased. Therefore, an LMA device on an integrated platform can play a similar role in power and energy scaling of integrated devices. In this work, we demonstrate LMA waveguide-based CMOS compatible watt-class high power amplifiers with an on-chip output power reaching beyond ~ 1 W within a footprint of only ~ 4 mm2. The power achieved is comparable and even surpasses many fiber-based amplifiers. We believe this work has the potential to radically change the integrated photonics application landscape, allowing power levels previously unimaginable from an integrated device replacing much of today’s benchtop systems. Moreover, mass producibility, reduced size, weight and cost will enable yet unforeseen applications for laser technology.
Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial
Authors: Kahn Steven E. , Deanfield John E. , Jeppesen Ole Kleist , Emerson Scott S. , Boesgaard Trine Welløv , Colhoun Helen M. , Kushner Robert F. , Lingvay Ildiko , Burguera Bartolome , Gajos Grzegorz , Horn Deborah Bade , Hramiak Irene M. , Jastreboff Ania M. , Kokkinos Alexander , Maeng Michael , Matos Ana Laura S.A. , Tinahones Francisco J. , Lincoff A. Michael , Ryan Donna H. ,   SELECT Trial Investigators
Published: June 2024

OBJECTIVE
To determine whether semaglutide slows progression of glycemia in people with cardiovascular disease and overweight or obesity but without diabetes.

RESEARCH DESIGN AND METHODS
In a multicenter, double-blind trial, participants aged ≥45 years, with BMI ≥27 kg/m2, and with preexisting cardiovascular disease but without diabetes (HbA1c &lt;6.5%) were randomized to receive subcutaneous semaglutide (2.4 mg weekly) or placebo. Major glycemic outcomes were HbA1c and proportions achieving biochemical normoglycemia (HbA1c &lt;5.7%) and progressing to biochemical diabetes (HbA1c ≥6.5%).

RESULTS
Of 17,604 participants, 8,803 were assigned to semaglutide and 8,801 to placebo. Mean ± SD intervention exposure was 152 ± 56 weeks and follow-up 176 ± 40 weeks. In both treatment arms mean nadir HbA1c for participants was at 20 weeks. Thereafter, HbA1c increased similarly in both arms, with a mean difference of −0.32 percentage points (95% CI −0.33 to −0.30; −3.49 mmol/mol [−3.66 to −3.32]) and with the difference favoring semaglutide throughout the study (P &lt; 0.0001). Body weight plateaued at 65 weeks and was 8.9% lower with semaglutide. At week 156, a greater proportion treated with semaglutide were normoglycemic (69.5% vs. 35.8%; P &lt; 0.0001) and a smaller proportion had biochemical diabetes by week 156 (1.5% vs. 6.9%; P &lt; 0.0001). The number needed to treat was 18.5 to prevent a case of diabetes. Both regression and progression were dependent on glycemia at baseline, with the magnitude of weight reduction important in mediating 24.5% of progression and 27.1% of regression.

CONCLUSIONS
In people with preexisting cardiovascular disease and overweight or obesity but without diabetes, long-term semaglutide increases regression to biochemical normoglycemia and reduces progression to biochemical diabetes but does not slow glycemic progression over time.
Pengembangan, Penyerahan, dan Pelatihan Sistem Informasi untuk Toko Sinar Terang di Kota Tangerang Selatan
Authors: Widjaja Andree Emmanuel , Gennady Erick , Hery  , Haryani Calandra A. , Prasetya Kusno , Aribowo Arnold 
Published: June 2024

Perkembangan teknologi informasi memberikan dampak positif bagi Usaha Kecil Mikro dan Menengah (UMKM). Toko Sinar Terang adalah UMKM yang berlokasi di Kota Tangerang Selatan yang menjual perabot rumah tangga. Pada sistem saat ini, ditemukan beberapa kendala di antaranya, kesalahan pencatatan keuangan, transaksi jual beli, persediaan produk, dan inkonsistensi data antar kedua cabang Toko. Guna mengatasi permasalahan tersebut, sebuah sistem informasi toko diperlukan. Selain itu, program loyalitas pelanggan juga dibutuhkan untuk menjaga dan meningkatkan relasi yang baik dengan pelanggan. Melalui kegiatan Pengabdian kepada Masyarakat (PkM) ini, sistem informasi untuk Toko Sinar Terang dikembangkan dengan metodologi RAD melalui metode prototyping. Pemodelan yang digunakan adalah UML yang mencakup class diagram, use case, dan activity diagram. Pengembangan sistem informasi menggunakan bahasa pemrograman PHP dengan framework CodeIgniter 4 dan PostgreSQL sebagai DBMS-nya. Hasil dari kegiatan PkM ini berupa sistem informasi untuk Toko Sinar Terang yang fungsional dan memiliki beragam fitur, seperti: persediaan, penjualan, keuangan, dan program loyalitas pelanggan yang dapat menampilkan informasi statistik untuk memberikan laporan persediaan yang terintegrasi. Sebelum sistem informasi diuji coba dan diserahkan, pelatihan penggunaan sistem informasi juga telah dilakukan kepada karyawan dan pemilik Toko.
Pelatihan Persiapan Olimpiade Sains Nasional Bidang Komputer Untuk Siswa SMA Pangudi Luhur Yogyakarta
Authors: Lukito Yuan , Chrismanto Antonius Rachmat , Wibowo Argo , Delima Rosa , Santosa Raden Gunawan , Haryono Nugroho Agus , Wijana Katon 
Published: June 2024

Kompetisi Olimpiade Sains Nasional (OSN) yang rutin diselenggarakan setiap tahunnya membutuhkan persiapan dari siswa-siswa sekolah yang ingin mengikuti kompetisi tersebut. SMA Pangudi Luhur Yogyakarta ingin mengikuti kompetisi tersebut dengan mengirimkan beberapa siswanya, sehingga membutuhkan pelatihan OSN untuk siswa-siswanya. Tim PKM dari Fakultas Teknologi Informasi bersedia untuk mengadakan pelatihan OSN dengan menyiapkan materi-materi dengan topik algoritma, logika dan aritmatika sesuai dengan silabus OSN. Pelatihan dilaksanakan selama 14 pertemuan di kampus Universitas Kristen Duta Wacana. Pelatihan tersebut telah berhasil dilaksanakan dengan baik dan berhasil memenuhi kebutuhan dari pihak sekolah. Pada materi algoritma didapatkan peningkatan rata-rata nilai post-test terhadap rata-rata nilai pre-test, yaitu meningkat dari 57,14 menjadi 97,14. Hasil evaluasi dari pelaksanaan pelatihan ini secara umum sudah baik dan sesuai kebutuhan, walaupun ada beberapa permasalahan seperti jadwal pelatihan yang terpaksa mundur dan tingkat partisipasi siswa yang makin menurun pada beberapa pertemuan akhir.
Exploring the Diverse Practices of Artificial Intelligence in Blended Music Teaching in Colleges and University
Authors: Zhang Wei 
Published: June 2024

Abstract
With the development of the information age and the change in media technology, the education industry has also ushered in a new change, and this paper focuses on the application of artificial intelligence in blended music teaching in colleges and universities. The first part of the article utilizes artificial intelligence to appreciate music emotions, utilizing Thayer’s two-dimensional emotion model and emotion vectors to express emotions in music. Then, the short- and long-time feature extraction of music emotion is carried out separately and normalized. Then, a music emotion recognition model based on the CNN-SVM model is constructed by combining a deep learning network and a space vector machine model. The constructed music emotion recognition model and SPOC hybrid teaching are utilized to establish a blended music diversity curriculum in colleges and universities and practical exploration is conducted. The results show that the time range of the change in music emotion perception is about 2.5~3.2s, and the recognition success rate is more than 4/5 for all kinds of music emotion segments. The correlation between the effect of music teaching and music diversification practice and students’ satisfaction is less than 0.01. The diversification of music teaching in this study can effectively stimulate students’ learning interest and improve learning efficiency in the music classroom.