bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERAN WANITA PESISIR PEDAGANG DALAM PEMENUHAN KEBUTUHAN PRIMER KESEHATAN KELUARGA (Studi Kasus Wanita Pedagang di Kawasan Pantai Kota Bengkulu)
Authors: Johan Syafri , Arwani Muhammad Marwan , Hartati Sri 
Published: February 2025

Penelitian ini bertujuan untuk mengetahui dan menganalisis peran wanita pesisir pedagang menjalankan fungsinya memenuhi kebutuhan primer kesehatan keluarga. Penelitian ini menggunakan teori fungsional struktural dan metode penelitian kuantitatif deskriptif analitik. Lokasi penelitian berada di kawasan Pantai Kota Bengkulu. Sasaran utama penelitian ini wanita pedagang di pantai. Data diperoleh melalui kuesioner dan disebarkankepada 32 responden. Sampel menggunakan teknik random sampling. Teknik analisis data menggunakan model analisis kuantitatif deskriptif analitik. Hasil penelitian menjelaskan bahwa pemeliharaan kesehatan dengan lima indikator yaitu, berperan memasak makanan 90,62%, berperan membeli pangan di pasar tradisional 83,12%, tidak berperan membeli pangan di pasar modern 39,37%, berperan membiasakan mandi, mencuci tangan dan menggosok gigi 90,00%, berperan menjaga jam tidur 67,50%, secara keseluruhan pemeliharaan kesehatan berperan 74,12%. Pencegahan penyakit dengan sembilan indikator yaitu berperan menyapu dan mengepel 89,37%, berperan menjaga kebersihan dapur 90,00%, tidak berperan membersihkan selokan 55,62%, tidak berperan melaksanakan 3M 55,62%, berperan menyiapkan tempat sampah 96,25%, berperan memeriksakan kehamilan 83,12%, berperanmelakukan imunisasi 89,37%, berperan selektif jajanan anak 71,87%, tidak berperan menggunakan kelambu 36,87%, secara keseluruhan pencegahan penyakit berperan 74,23%. Pencarian pengobatan dengan tiga indikator yaitu berperan membeli obat 70,62%, berperan ke puskesmas 80,62%, tidak berperan ke rumah sakit 44,37%, secara keseluruhan pencarian pengobatan berperan 65,20%. Pemulihan kesehatan dengan dua indikator yaitu, berperan memberikan perawatan 94,37%, berperan memastikan mengkonsumsi obat secara rutin dan tepat waktu 95,00%, secara keseluruhan pemulihan kesehatan berperan 94,68%. Kata Kunci : Peningkatan dan Pemeliharaan Kesehatan, Pencegahan Penyakit, Pencarian Pengobatan, dan Pemulihan Kesehatan.
PERAN DUKUN DALAM PERAWATAN BAYI PERIODE PERINATAL (Studi Kasus di Desa Sidoharjo, Kecamatan Tugumulyo, Kabupaten Musirawas, Sumatera Selatan)
Authors: Suratmini Suratmini , Pramudyasmono Hajar G , Hanum Sri Handayani 
Published: February 2025

Penelitian ini bertujuan untuk (1). mengetahui kedudukan sosial dukun dalam masyarakatnya, (2). mendeskripsikan peranan yang dilakukan oleh dukun bayi dalam perawatan bayi periode perinatal, (3). menggali informasi tentang rincian perawatan bayiyang dilakukan oleh dukun bayi pada periode perinatal. Penelitian ini menggunakan metode kualitatif deskriptif dan menggunakan paradigma fakta sosial dengan teori struktural fungsional sebagai alat analisisnya. Informan diperoleh dengan teknik purposive sampling yaitu ibu-ibu yang memiliki bayi yang berumur 0-12 bulan serta dukun bayi yang melakukan perawatan bayi selama periode perinatal. Pengumpulan data dilakukan dengan menggunakan teknik observasi dan wawancara. Analisis data dilakukan dari reduksi data, penyajian data serta penarikan simpulan untuk mendapatkan konsep-konsep sebagai hasil penelitian. Penelitian ini menyimpulkan bahwa kedudukan sosial dukun bayi dalam masyarakat yakni sebagai pemimpin ritual-ritual dalam masyarakat seperti pemimpin ritual mitoni, menguburkan ari-ari, pemimpin ritus brokohan, pemimpin ritus sepasaran, dan mitra bidan saat proses persalinan, sertapemberi nasehat. Peran yang dilakukan oleh dukun bayi dalam melakukan perawatan bayi pada periode perinatal yakni memijat bayi, memandikan bayi, serta merawat tali pusat bayi. Dukun bayi menjadi mitra bidan karena adanya peraturan dari Departemen Kesehatan yang mengharuskan pertolongan persalinan dilakukan oleh tenaga medis terlatih. Kepercayaan warga masyarakat terhadap dukun bayi dilatarbelakangi oleh kesamaan budaya, lingkungan sosial yang sama serta adanya kedekatan secara emosional yang terjalin antara dukun bayi dengan warga masyarakat desa Sidoharjo. Kata Kunci : Dukun, Perawatan Perinatal.
POLA KOMUNIKASI PELAYANAN LANSIA DALAM PERSPEKTIF ADAT BUDAYA DI BENGKULU
Authors: Hadiprashada Dhanurseto , Osira Yessilia 
Published: February 2025

Lanjut Usia (lansia) memiliki kerentanan aspek fisik, mental, sosial, maupun ekonomi, sehingga memerlukan pelayanan yang optimal. Pelayanan ini bisa dicapai melalui pola komunikasi yang tepat bagi para lansia, yang sesuai dengan adat budaya masing-masing lansia. Penelitian deskriptif kualitatif ini dilakukan untuk mengkaji Pola Komunikasi Pelayanan Lansia dalam Perspektif Adat Budaya Di Bengkulu, khususnya adat budaya Suku Serawai di Desa Talang Kabu Kecamatan Ilir Talo Kabupaten Seluma. Pengumpulan data dilakukan melalui wawancara mendalam, diskusi kelompok terfokus, studi dokumentasi dan observasi lapangan. Data yang terkumpul kemudian diolah dan dianalisa secara kualitatif sehingga tercapai maksud dan tujuan penelitian. Hasil penelitian menunjukkan: 1) Masyarakat Desa Talang Kabu, merupakan kumpulan masyarakat yang berasal dari tiga jungku (komunitas) yaitu Jungku Talang Kabu Lamo, Jungku Patih Layang dan Jungku Penago. 2) Suku Serawai, khususnya di Desa Talang Kabu memandang makna lansia sebagai orang yang dihormati, dimuliakan, dan dituakan dalam kehidupan masyarakat desa. Hal ini terlihat dari cara komunikasi atau interaksi masyarakat desa dengan orang tua atau lansia, baik yang masih hidup maupun para orang tua yang sudah meninggal dunia, 3) Pelayanan terhadap warga lanjut usia di Talang Kabu dilakukan melalui: a) Pola komunikasi primer sebagaimana dilakukan oleh lansia dalam menyampaikan nasehat kehidupan bagi anak dan cucunya yang sedang melaksanakan prosesi pernikahan, b) Pola komunikasi sekunder, seperti berkomunikasi melalui gambar dalam handphone untuk menjelaskan maksud yang akan disampaikan, c) Pola komunikasi linier, sebagaimana diterapkan ketika mengarahkan perilaku lansia untuk memenuhi kebutuhan hidup sehari-hari atau mengarahkan lansia melaksanakan aktifitas keseharian. Pola komunikasi pelayanan pada lansia ini mencakup fungsi komunikasi; sosial, ekspresif, ritual, dan instrumental. Berdasarkan hasil penelitian, maka direkomendasikan kepada Kepala Desa Talang Kabu dan Aparat Desa, dibantu Kelompok PKK, Posyandu, dan Lembaga Adat, untuk: 1) Pembuatan profil masing- masing lansia 2) Pembentukan Paguyuban Keluarga Lansia di Desa Talang Kabu, 3) Mengaktifkan kembali ruang kreatifitas warga lanjut usia.Kata Kunci : Adat Budaya, Pola Komunikasi, Pelayanan Lansia
Intensification of Vero cell adherence to microcarrier particles during cultivation in a wave bioreactor
Authors: Mazhed Z. K. , Vasilenko V. E. , Siniugina A. A. , Kaa K. V. , Motov A. S. , Pokidova K. O. , Ivin Y. Y. , Piniaeva A. N. , Khapchaev Y. K. , Chernov K. A. , Ishmukhametov A. A. 
Published: February 2025

Vaccination is the most effective strategy for fighting viral diseases, with both live and inactivated vaccines remaining crucial despite advancements in subunit vaccine technologies. A key player in vaccine production is the Vero cell line, derived from the kidney cells of the African green monkey, which is essential for manufacturing vaccines against diseases like polio, rabies, yellow fever, and COVID-19. The efficiency of Vero cell cultivation directly impacts vaccine production, often utilizing bioreactors ranging from small (1–10 L) to large (up to several thousand liters). Wave-type bioreactors are commonly employed for initial cell propagation due to their simplicity. However, achieving uniform cell distribution on microcarriers in these systems poses challenges. This study aims to evaluate intermittent stirring during the early cultivation stages to enhance Vero cell distribution and growth, potentially improving overall cultivation efficiency.
Deficient perceptions and practices concerning elevated lipoprotein(a) among specialists in Singapore
Authors: Loh Wann Jia , Pang Jing , Simon Oliver , Chan Dick C. , Watts Gerald F. 
Published: February 2025

BackgroundMultiple guidelines recommend detection of and early risk factor management for elevated lipoprotein(a) [Lp(a)]. Effective implementation requires assessment of knowledge and practices regarding elevated Lp(a) among medical specialists.AimTo assess awareness, knowledge and practices of the detection and treatment of elevated Lp(a) among specialist physicians in Singapore.MethodsSeventy-five practicing specialists in cardiology (n = 33) or endocrinology (n = 42) anonymously completed a structured questionnaire that assessed the above three aims.ResultsThe majority of respondents (83%) rated their familiarity with Lp(a) as at least average, with a greater percentage of endocrinologists being less familiar with Lp(a) than cardiologists (29% vs. 3%, P &lt; 0.01). 57% were aware of at least one guideline or consensus statement on Lp(a), which was more frequent among cardiologists than endocrinologists (70% vs. 48%, P = 0.05). There were major gaps in knowledge of the prevalence, pathophysiological role, clinical significance and management of elevated Lp(a), correct responses being less than 30%; 44% of respondents (33% cardiologists and 52% endocrinologists) never tested for Lp(a), lack of effective treatment being the most common barrier (59%). A higher proportion of specialists that did not test for Lp(a) rated familiarity with Lp(a) as being low compared with specialists that tested for Lp(a) regularly (33% vs. 13%, P = 0.02). Education and training were considered most useful for improving care of patients with elevated Lp(a).ConclusionMajor gaps in awareness, knowledge and management of elevated Lp(a) were identified among specialists in Singapore. Education and training of specialists are required to overcome initial barriers to testing.
Equitable hospital length of stay prediction for patients with learning disabilities and multiple long-term conditions using machine learning
Authors: Abakasanga Emeka , Kousovista Rania , Cosma Georgina , Akbari Ashley , Zaccardi Francesco , Kaur Navjot , Fitt Danielle , Jun Gyuchan Thomas , Kiani Reza , Gangadharan Satheesh 
Published: February 2025

PurposeIndividuals with learning disabilities (LD) often face higher rates of premature mortality and prolonged hospital stays compared to the general population. Predicting the length of stay (LOS) for patients with LD and multiple long-term conditions (MLTCs) is critical for improving patient care and optimising medical resource allocation. However, there is limited research on the application of machine learning (ML) models to this population. Furthermore, approaches designed for the general population often lack generalisability and fairness, particularly when applied across sensitive groups within their cohort.MethodThis study analyses hospitalisations of 9,618 patients with LD in Wales using electronic health records (EHR) from the SAIL Databank. A Random Forest (RF) ML model was developed to predict hospital LOS, incorporating demographics, medication history, lifestyle factors, and 39 long-term conditions. To address fairness concerns, two bias mitigation techniques were applied: a post-processing threshold optimiser and an in-processing reductions method using an exponentiated gradient. These methods aimed to minimise performance discrepancies across ethnic groups while ensuring robust model performance.ResultsThe RF model outperformed other state-of-the-art models, achieving an area under the curve of 0.759 for males and 0.756 for females, a false negative rate of 0.224 for males and 0.229 for females, and a balanced accuracy of 0.690 for males and 0.689 for females. Bias mitigation algorithms reduced disparities in prediction performance across ethnic groups, with the threshold optimiser yielding the most notable improvements. Performance metrics, including false positive rate and balanced accuracy, showed significant enhancements in fairness for the male cohort.ConclusionThis study demonstrates the feasibility of applying ML models to predict LOS for patients with LD and MLTCs, while addressing fairness through bias mitigation techniques. The findings highlight the potential for equitable healthcare predictions using EHR data, paving the way for improved clinical decision-making and resource management.
TOWARD, a metabolic health intervention, demonstrates robust 1-year weight loss and cost-savings through deprescription
Authors: Buchanan Laura , Calkins Matthew , Kalayjian Tro , Norwitz Nicholas G. , Teicholz Nina , Unwin David , Soto-Mota Adrian 
Published: February 2025

BackgroundCost, scalability, and durability represent major challenges to the implementation of intensive lifestyle treatments for obesity and diabetes. We previously reported pilot data from a 6-month intervention in which a self-insured manufacturing company partnered with a metabolic health clinic that utilizes therapeutic carbohydrate reduction (TCR), asynchronous monitoring, and a community-based approach to treat employees with metabolic disease. This manuscript presents weight loss and cost-savings from deprescription at the 12-month time point.Methods50 employees, mean BMI 43.2 ± 8.7 kg/m2, 64% with prediabetes or type 2 diabetes, were enrolled in the multimodal TOWARD telemedicine intervention, which includes: Text-based communications, Online interactions, Wellness coaching, Asynchronous education, Real-time biofeedback and remote monitoring, and Dietary modifications that emphasizes TCR.Results41 completed the one-year intervention. Mean weight loss for the 50 subjects in the intention-to-treat analysis was 19.5 ± 11.4 kg, corresponding to 15.5% total body weight loss with concomitant deprescription of 96 medications, while starting only 8 medications. In patients who discontinued GLP-1 receptor agonists, weight loss continued or was maintained. Annualized cost savings from the TOWARD approach were approximately -$1700 per patient, as compared to an annualized cost burden of roughly +$13000 per patient for a GLP-1 receptor agonist.ConclusionThe TOWARD approach represents a scalable metabolic health intervention that demonstrates robust improvements in weight while simultaneously allowing for deprescription leading to substantial cost savings. TOWARD could serve as a scalable tool to facilitate intensive lifestyle intervention with efficacy on par with GLP-1 receptor agonists.
Ensartinib for EML4-ALK-positive lung adenocarcinoma with comorbid mutations in TP53, EGFR, and ERBB2: a case report
Authors: Huang Xiaoqing , Zhou Lingxian , Xia Jianyong , Jian Haifeng , Liu Jinji , Huang Yunying , Chen Qingsheng 
Published: February 2025

BackgroundIn non-small cell lung cancer (NSCLC), anaplastic lymphoma kinase (ALK) gene rearrangements are commonly detected in lung adenocarcinoma. ALK-positive (ALK+) patients may occasionally exhibit concurrent genetic alterations that potentially impact prognosis. New therapeutic strategies are needed for ALK+ NSCLC patients with multiple simultaneous gene mutations.Case presentationA 58-year-old man was diagnosed with lung adenocarcinoma (stage IVB, T4N3M1c) with an echinoderm microtubule-associated protein-like 4-ALK+ (EML4-ALK+) rearrangement, harboring tumor protein 53 (TP53), epidermal growth factor receptor (EGFR), and receptor tyrosine-protein kinase erbB-2 (ERBB2) mutations. After three cycles of chemotherapy, the patient developed intolerance. Subsequently, ensartinib (225 mg daily) was administered orally on April 14, 2021. After 3 months of ensartinib treatment, the patient achieved a partial response and reached stable disease at six months, which sustained for 30 months till April 8, 2024, with grade 1 rash and no brain metastases. Currently, the patient remains on ensartinib treatment, without disease progression.ConclusionThis case demonstrates the potential for ensartinib in the treatment of EML4-ALK+ lung adenocarcinoma with multiple gene mutations. Further investigation through clinical trials is needed to evaluate the safety and efficacy of this targeted therapy.
Case report: Aumolertinib plus gumarontinib in a patient with EGFR mutated non-small-cell lung cancer harboring acquired MET amplification following progression on afatinib plus crizotinib
Authors: Hui Jia-Jun , Ding Sheng-Jun , Qin Bao-Dong , Ding Ning 
Published: February 2025

BackgroundAlthough it remained fully unclear about the optimal regimen for Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistant non-small cell lung cancer (NSCLC) patients with Mesenchymal-Epithelial Transition factor (MET) amplification, the dual inhibition of EGFR inhibitor with MET inhibitor were attempted in clinical practice. There is very limited literature on the subsequent treatment when patients develop the resistance to this combination regimen.Case summaryThe patient, a 49-year-old female, initially presented with EGFR exon 21 L858R metastatic lung adenocarcinoma, treated successfully with first-line afatinib on September 2022 with a progression-free survival (PFS) of 8.0 months. On May 2023, she developed chest tightness and was found to have pericardial and pleural effusions containing malignant cells, indicating disease progression. Next-generation sequencing using pericardial effusion revealed concurrent EGFR L858R mutation and MET amplification. Then, afatinib plus crizotinib was initiated as second-line regimen, achieving stable disease with a PFS of 13.5 months. On July 2024, the patient developed the resistance to afatinib plus crizotinib due to the appearance of brain metastases. Then, this patient was administrated with aumolertinib plus gumarontinib as third-line regimen. Remarkably, this led to significant radiographic improvement of brain metastases. This patient is still undergoing third-line treatment, with a PFS of 3.7 months.ConclusionThis case underscores the importance of re-challenge using third-generation EGFR-TKI with novel MET-TKI after the failure of second-generation EGFR-TKI plus crizotinib in EGFR-TKI resistant NSCLC patients with MET amplification, especially in patients with brain metastases. The successful application of aumolertinib plus gumarontinib highlights its potential in overcoming MET amplification-induced EGFR-TKI resistance, which warrants further investigation in future large-scale clinical trials.
The effect of transcranial pulse current stimulation on the accumulation of exercise-induced fatigue in college students after moderate intensity exercise evidence from central and peripheral sources
Authors: Wu Qingchang , Liu Siyan , Wu Changli , Liu Jian 
Published: February 2025

ObjectiveTo investigate the intervention effect of cranial pulse current stimulator (tPCS) on fatigue accumulation after moderate-intensity exercise by using blood analysis and functional near-infrared spectroscopy, and to analyze the type and magnitude of the fatigue effect of tPCS on fatigue in combination with behavioral performance.MethodsNinety healthy college students were randomly and equally divided into an experimental group (Group A) and a control group (Group B), and both groups underwent moderate-intensity training for 7 days. Before and after the experiment, all subjects received physiological, biochemical, behavioral, and subjective fatigue indexes, followed by exercise training, and each day of exercise training was followed by tPCS intervention (stimulus intensity of 1.5 mA, stimulus duration of 20 min) and subjective fatigue scale (RPE) test.Results① After the tPCS intervention, the daily RPE scores of group A were smaller than those of group B; ② The values of the indexes oxygenated hemoglobin concentration (Oxy-Hb), deoxyhemoglobin concentration (HHb), testosterone (T), and testosterone-to-cortisol ratio (T/C) of group A did not differ significantly from those of the pre-intervention period, and the values of all the indexes of group B were significantly different from those of the pre-intervention period. ③ After tPCS intervention, the values of Oxy-Hb, T, T/C, and on-attention decreased in Groups A and B, with Oxy-Hb decreasing the most; the values of HHb, total hemoglobin concentration (HbTot), hemoglobin concentration difference (HbDiff), cortisol (C), creatine kinase (CK), and reaction time (RT) increased, with the greatest increase in HbDiff; and the Group A The magnitude of change of each index was smaller than that of Group B. After tPCS intervention, the contribution of central fatigue to the effect of reaction time science was greater than that of peripheral fatigue.Conclusion① tPCS can delay the development of central fatigue and peripheral fatigue. ② The effect of tPCS on central fatigue is greater than on peripheral fatigue. ③ The effect of tPCS on reaction timing is mainly realized by changing the state of central fatigue.
Protective Effects of Centella asiatica Against Senescence and Apoptosis in Epidermal Cells
Authors: Tan Yu , Hu Ailing , Lu Jingya , Lin Yunhai , Li Xuejing , Yamaguchi Takuji , Tabuchi Masahiro , Kawakami Zenji , Ikarashi Yasushi , Kobayashi Hiroyuki 
Published: February 2025

Centella asiatica, a traditional medicinal plant, possesses potent antioxidant activity and may therefore prevent cellular aging and exert antiapoptotic effects. However, these effects remain to be fully elucidated. This study aimed to investigate the protective effects of C. asiatica extract against cellular senescence and apoptosis caused by hydrogen peroxide (H2O2)-induced oxidative stress in human epidermal keratinocytes (HaCaT cells). To evaluate the effects of H2O2 and C. asiatica on HaCaT cells, we measured cell viability as a marker of cell death; reactive oxygen species (ROS), radical scavenging, superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activities as markers of oxidative stress; senescence-associated β-galactosidase (SA-β-gal) activity as a marker of cellular senescence; and caspase-3/9 activities and apoptotic cells as markers of apoptosis. H2O2 induced cell death (decreased cell viability), oxidative stress (increased ROS activity, decreased radical scavenging, SOD, GPx, and catalase activities), cellular senescence (increased SA-β-gal activity), and apoptosis (increased early/late apoptotic cells and increased caspase-3/9 activities). C. asiatica significantly decreased all markers of H2O2-induced cell death, oxidative stress, cellular senescence, and apoptosis, suggesting its ability to prevent cellular senescence and apoptosis through its antioxidant activity. This mechanism of action may contribute to the prevention and improvement of skin aging.