bluuebunny/crossref_metadata_2025_split huggingface dataset:
The future
Authors: Fransson Boel 
Published: December 2013

Practical relevance: Laparoscopic surgery minimizes tissue trauma and speeds recovery, but its uptake into veterinary clinical practice has been slow. Clinical challenges: Laparoscopy is distinctly different from traditional open surgery and a reduced working area and loss of depth perception are among the challenges that the surgeon must get to grips with. Indeed, it is often lack of the necessary skills, rather than the cost of equipment, that presents the greatest obstacle. Audience: This article is aimed at practitioners keen to embrace minimally invasive surgery and advises on how to develop excellence in laparoscopic skills. It makes the case for simulation training and outlines methods that can be instituted in practice at low cost and with comparatively little time expenditure. It also describes technological advances that have already increased the success of veterinary ‘keyhole’ surgery, as well as those that look promising for the future. Evidence base: Simulation training has been an intense area of research and publication within the past 15 years. This article draws on that evidence base and the experience gained by the author and her research team, which is at the forefront of efforts to develop laparoscopic training for veterinarians.
2013 AAFP Feline Vaccination Advisory Panel Report
Authors: Scherk M A , Ford R B , Gaskell R M , Hartmann K , Hurley K F , Lappin M R , Levy J K , Little S E , Nordone S K , Sparkes A H 
Published: December 2013

Regrettably, two errors appeared in the 2013 AAFP Feline Vaccination Advisory Panel Report. Firstly, in the ‘Injectable vaccine administration’ box, on page 798, the pictures in Figures 8 and 9 were swapped with each other. The amended box is reproduced here. Secondly, the penultimate sentence in the second ‘Trap–Neuter–Return’ FAQ on page 804 should have read: ‘In contrast, only inactivated vaccines resulted in a high rate of protective antibodies against FHV-1,’ and not ‘In contrast, only modified-live vaccines …’. The errors appear in the printed copies of the journal, and in online versions downloaded before November 2013. DOI of original article: 10.1177/1098612X13500429 DOI: 10.1177/1098612X13511888
Education for nurses working in cardiovascular care: A European survey
Authors:   The Working Group of the Education Committee of the ESC Council on Cardiovascular Nursing and Allied Professions, Astin Felicity , Carroll Diane L , De Geest Sabina , Martensson Jan , Jones Ian , Hunterbuchner Lynne , Jennings Catriona , Kletsiou Eleni , Serafin Agnieska , Timmins Fiona 
Published: December 2013

Background: Nurses represent the largest sector of the workforce caring for people with cardiovascular disease in Europe. Little is known about the post-registration education provided to nurses working within this specialty. The aim of this descriptive cross sectional survey was to describe the structure, content, teaching, learning, assessment and evaluation methods used in post-registration cardiovascular nurse education programmes in Europe. Method: A 24-item researcher generated electronic questionnaire was sent to nurse representatives from 23 European countries. Items included questions about cardiovascular registered nurse education programmes. Results: Forty-nine respondents from 17 European countries completed questionnaires. Respondents were typically female (74%) and educated at Masters (50%) or doctoral (39%) level. Fifty-one percent of the cardiovascular nursing education programmes were offered by universities either at bachelor or masters level. The most frequently reported programme content included cardiac arrhythmias (93%), heart failure (85%) and ischaemic heart disease (83%). The most common teaching mode was face-to-face lectures (85%) and/or seminars (77%). A variety of assessment methods were used with an exam or knowledge test being the most frequent. Programme evaluation was typically conducted through student feedback (95%). Conclusion: There is variability in the content, teaching, learning and evaluation methods in post-registration cardiovascular nurse education programmes in Europe. Cardiovascular nurse education would be strengthened with a stronger focus upon content that reflects current health challenges faced in Europe. A broader view of cardiovascular disease to include stroke and peripheral vascular disease is recommended with greater emphasis on prevention, rehabilitation and the impact of health inequalities.
Adherence reporting in randomized controlled trials
Authors: Zhang Ze , Peluso Michael J , Gross Cary P , Viscoli Catherine M , Kernan Walter N 
Published: December 2013

Background Treatment adherence may influence the therapeutic effect that is observed in a randomized controlled trial (RCT). Adherence may also be an indicator of research quality and treatment acceptance by participants. Despite the importance of adherence in RCT research, little is known about current practices for its measurement and reporting. Purpose The objective of this study was to determine and evaluate adherence measurement and reporting practices in RCTs involving oral pharmacologic interventions published in high impact factor journals. Methods We conducted a systematic review of RCTs involving oral pharmacotherapy published during 2010 in 10 high-impact general medicine and subspecialty journals. Two investigators independently abstracted data regarding trial characteristics, adherence monitoring, and adherence reporting. Differences were reconciled in conference. Descriptive statistics were calculated, statistical comparisons were made using chi-square analysis, and associations assessed using Spearman’s rank correlation coefficient. Results Of 111 RCT manuscripts included in the sample, 51 (45.9%) reported study-drug adherence among participants. Studies that reported adherence results were more likely to report negative findings (i.e., no significant treatment effect in a superiority trial, non-equivalence in an equivalence trial) (p = 0.032). The most common method for adherence monitoring was pill count-back on returned bottles. Among the studies that reported adherence, the median adherence was 88.4% (range: 48%−100%), and trials with longer follow-up time reported lower adherence (r = −0.45; p = 0.0015). A minority of the 51 studies described a strategy for calculating adherence that accounted for participants who were lost to follow-up (11/51 studies; 21.6%), discontinued the study medication temporarily (6/51 studies; 11.8%), or discontinued the study drug permanently (1/51 study; 2%). Limitations This study is limited by the inclusion of a small set of journals with the highest impact factors in specific fields of clinical medicine, including general medicine. Although the analysis pertains to studies published in 2010, no new guidelines in the field since the last Consolidated Standards of Reporting Trials (CONSORT) statement have been issued that would be expected to change practices for adherence monitoring, analysis, and reporting. Conclusions Adherence measurement methodology and results are underreported in published RCTs. In the minority of RCTs that provided adherence information, there was substantial heterogeneity in how adherence was defined, analyzed, and reported. Improved reporting of adherence may enhance the interpretation of study quality and results.
Test–retest reliability and validity of normative cut-offs of the two devices measuring touch threshold: Weinstein Enhanced Sensory Test and Pressure-Specified Sensory Device
Authors: Uddin Zakir , MacDermid Joy C , Ham Hyungjoo H 
Published: December 2013

Introduction Touch threshold screening instruments must accurately distinguish normal versus abnormal sensation to screen nerve pathology. This study was conducted to find out whether two touch threshold measuring devices (i.e. Weinstein Enhanced Sensory Test (WEST) and Pressure-Specified Sensory Device (PSSD) provide consistent results and indicators of “normal” sensation, and secondarily what rules best define normality. Methods The study design was a cross-sectional reliability and validity assessment with 23 healthy participants. Instruments were applied in random order on the pulp of the middle and little fingers of both hands; with five applications on each digit. Cut-offs of 3, 4, and 5 correct responses were used to classify the response as being normal. Weighted kappa and percent agreement were used to indicate test–retest reliability of the WEST, and validity was determined by calculating the percentage of normal controls that achieved a normal score. The Bland–Altman method was used to characterize the retest reliability of PSSD, and validity was determined by whether the mean of the score is different from the normative scores. Results The agreement between test and retest of WEST (detection level = 3/5) was almost perfect ( k = 1). The average percentages of normal detection of the WEST on two test/retest were 93% and 97% (detection level = 4/5) and 82% and 85% (detection level = 5/5). All mean PSSD tests values were found within the predetermined normal range. The Bland–Altman plot demonstrated a minimal mean difference between test occasions and similar limits of agreement across the four test locations. Discussion The study found that more than 90% of the tests with healthy young participants were reliable and valid in relation to their ability to detect a normal WEST filament or PSSD within a normal force range. Our study was limited by a small sample with healthy participants.
Rituximab is associated with improved survival in Burkitt lymphoma: a retrospective analysis from two US academic medical centers
Authors: Wildes Tanya M. , Farrington Laura , Yeung Cecilia , Harrington Alexandra M. , Foyil Kelley V. , Liu Jingxia , Kreisel Friederike , Bartlett Nancy L. , Fenske Timothy S. 
Published: December 2013

Background: Burkitt lymphoma (BL) is a rare, highly aggressive B-cell malignancy treated most successfully with brief-duration, high-intensity chemotherapeutic regimens. The benefit of the addition of rituximab to these regimens remains uncertain. We sought to examine the effectiveness of chemotherapy with and without rituximab in patients with BL. Methods: This study is a retrospective cohort study of all adult patients with BL diagnosed and treated with modern, dose-intense chemotherapeutic regimens from 1998–2008 at two tertiary care institutions. All cases were confirmed by application of WHO 2008 criteria by hematopathologists. Medical records were reviewed for patient-, disease-, and treatment- related factors as well as treatment response and survival. Factors associated with survival were analyzed using Cox proportional hazards modeling. Results: A total of 35 patients were analyzed: 18 patients received rituximab with chemotherapy (R-chemo) and 17 received chemotherapy (chemo) alone. The median age was 42 (range 20–74 years); 57% were male; 71% had Ann Arbor Stage IV disease; 33% had central nervous system involvement; 78% had an Eastern Cooperative Oncology Group (ECOG) performance status of 0–1. R-chemo was associated with significantly longer overall survival (OS) than chemo alone (5-year OS 70% and 29%, respectively, p = 0.040). On multivariate regression analysis, poor performance status and central nervous system involvement were associated with poorer survival. Conclusions: The addition of rituximab to chemotherapy was associated with improved OS in patients with Burkitt lymphoma. Poor performance status and central nervous system involvement were prognostically significant on multivariate analysis.
Early feeding and neonatal hypoglycemia in infants of diabetic mothers
Authors: Cordero Leandro , Ramesh Shilpa , Hillier Kirsty , Giannone Peter J , Nankervis Craig A 
Published: December 2013

Objectives: To examine the effects of early formula feeding or breast-feeding on hypoglycemia in infants born to 303 A1-A2 and 88 Class B-RF diabetics. Methods: Infants with hypoglycemia (blood glucose < 40 mg/dL) were breast-fed or formula-fed, and those with recurrences were given intravenous dextrose. Results: Of 293 infants admitted to the well-baby nursery, 87 (30%) had hypoglycemia, corrected by early feeding in 75 (86%), while 12 (14%) required intravenous dextrose. In all, 98 infants were admitted to the newborn intensive care unit for respiratory distress (40%), prematurity (33%) or prevention of hypoglycemia (27%). Although all newborn intensive care unit patients received intravenous dextrose, 22 (22%) had hypoglycemia. Of 109 hypoglycemia episodes, 89 (82%) were single low occurrences. At discharge, 56% of well-baby nursery and 43% of newborn intensive care unit infants initiated breast-feeding. Conclusions: Hypoglycemia among infants of diabetic mothers can be corrected by early breast-feeding or formula feeding.
A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin
Authors: Kim Airie , Fung Eileen , Parikh Sona G. , Valore Erika V. , Gabayan Victoria , Nemeth Elizabeta , Ganz Tomas 
Published: December 2013

Key Points
An injection of heat-killed Brucella abortus in mice causes prolonged anemia with features similar to human anemia of inflammation. Ablation of hepcidin ameliorates anemia of inflammation in this model and allows faster recovery.
B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia
Authors: Zheng Yongwei , Wang Alexander W. , Yu Mei , Padmanabhan Anand , Tourdot Benjamin E. , Newman Debra K. , White Gilbert C. , Aster Richard H. , Wen Renren , Wang Demin 
Published: December 2013

Key Points
B-cell tolerance plays a critical role in controlling production of PF4/heparin-specific antibodies.
Identical twins:one with anti-glomerular basement membrane glomerulonephritis,the other with systemic lupus erythematosus
Authors: Liu Xiaoxia , Wu Yu , Yang Yuan , Wang Jue , Tao Ye , Fu Ping , Hu Zhangxue 
Published: December 2013

Abstract

Background
Anti-glomerular basement membrane (GBM) glomerulonephritis and systemic lupus erythematosus (SLE) are both disorders of the immune system; however, they are known as distinct diseases. Till now no clinical evidence suggests the genetic relationship between these two diseases. Herein, we present two identical twins; one was diagnosed as anti-GBM glomerulonephritis, the other SLE. This is the first clinical report on the genetic relationship between these two diseases.

Case presentation
A 25-year-old female was admitted complaining of intermittent gross hematuria for 6 months and elevated serum creatinine for 1 month. She denied hemoptysis. Laboratory examinations showed hemoglobin 7.4 g/dL, serum creatinine 7.15 mg/dL and albumin 2.8 g/dL. Urinalysis showed hematuria (484 RBCs per high-power field) and proteinuria 4+. Antinuclear antibody, complement levels and ANCAs were all normal. Renal ultrasound showed normal-sized kidneys without obstruction or masses. Serum anti-GBM antibody assay showed 119.70 RU/mL (normal range, <20 RU/mL). Chest X-ray was normal. She was diagnosed as anti-GBM glomerulonephritis and received plasma exchange (2000-3000 ml plasma/exchange, 5 turns), methylprednisolone 0.5 g for three days, plus cyclophosphamide. Although serum anti-GBM antibodies decreased gradually to a normal range, her renal function did not improve. One month later, her identical twin sister was diagnosed as SLE based on malar erythema, arthralgia, antinuclear antibody positive with liter 1:1000, and Anti-Smith (Sm) antibody ++. Anti-GBM antibody and complements were within normal ranges. Further study showed these twins were HLA-DRB1*1501 homozygotes.

Conclusion
The presence of identical twins having anti-GBM nephritis and SLE respectively provides clinical evidence to support that anti-GBM nephritis and lupus may share a common genetic background to some extent, while environment may contribute to disease evolution in part.
Growth and metabolic outcome in adolescents born preterm (GROWMORE): follow-up protocol for the Newcastle preterm birth growth study (PTBGS)
Authors: Wood Claire L , Tinnion Robert J , Korada S Murthy , Cheetham Timothy D , Relton Caroline L , Cooke Richard J , Pearce Mark S , Hollingsworth Kieren G , Trenell Michael I , Embleton Nicholas D 
Published: December 2013

Abstract

Background
Preterm infants represent up to 10% of births worldwide and have an increased risk of adverse metabolic outcomes in later life. Early life exposures are key factors in determining later health but current lifestyle factors such as diet and physical activity are also extremely important and provide an opportunity for targeted intervention.

Methods/Design
This current study, GROWMORE, is the fourth phase of the Newcastle Preterm Birth Growth Study (PTBGS), which was formed from two randomised controlled trials of nutrition in early life in preterm (24–34 weeks gestation) and low birthweight infants. 247 infants were recruited prior to hospital discharge. Infant follow-up included detailed measures of growth, nutritional intake, morbidities and body composition (Dual X Ray Absorptiometry, DXA) along with demographic data until 2 years corrected age. Developmental assessment was performed at 18 months corrected age, and cognitive assessment at 9–10 years of age. Growth, body composition (DXA), blood pressure and metabolic function (insulin resistance and lipid profile) were assessed at 9–13 years of age, and samples obtained for epigenetic analysis. In GROWMORE, we will follow up a representative cohort using established techniques and novel metabolic biomarkers and correlate these with current lifestyle factors including physical activity and dietary intake. We will assess auxology, body composition (BODPOD™), insulin resistance, daily activity levels using Actigraph™ software and use 31P and 1H magnetic resonance spectroscopy to assess mitochondrial function and intra-hepatic lipid content.

Discussion
The Newcastle PTBGS is a unique cohort of children born preterm in the late 1990’s. The major strengths are the high level of detail of early nutritional and growth exposures, and the comprehensive assessment over time. This study aims to examine the associations between early life exposures in preterm infants and metabolic outcomes in adolescence, which represents an area of major translational importance.
A colorimetric method for the molecular weight determination of polyethylene glycol using gold nanoparticles
Authors: Ling Kai , Jiang Hongyan , Zhang Qiqing 
Published: December 2013

Abstract
A gold nanoparticle (AuNP)-based colorimetric method was developed for the molecular weight (MW) determination of polyethylene glycol (PEG), a commonly used hydrophilic polymer. Addition of a salt solution to PEG-coated AuNP solutions helps in screening the electrostatic repulsion between nanoparticles and generating a color change of the solutions from wine red to blue in 10 min in accordance with the MW of PEG, which illustrates the different stability degrees (SDs) of the AuNPs. The SDs are calculated by the absorbance ratios of the stable to the aggregated AuNPs in the solution. The root mean square end-to-end length (〈h
2〉1/2) of PEG molecules shows a linear fit to the SDs of the PEG-coated AuNPs in a range of 1.938 ± 0.156 to 10.151 ± 0.176 nm. According to the Derjaguin-Landau-Verwey-Overbeek theory, the reason for this linear relationship is that the thickness of the PEG adlayer is roughly equivalent to the 〈h
2〉1/2 of the PEG molecules in solution, which determines the SDs of the AuNPs. Subsequently, the MW of the PEG can be obtained from its 〈h
2〉1/2 using a mathematical relationship between 〈h
2〉1/2 and MW of PEG molecule. Applying this approach, we determined the 〈h
2〉1/2 and the MW of four PEG samples according to their absorbance values from the ordinary ultraviolet–visible spectrophotometric measurements. Therefore, the MW of PEG can be distinguished straightforwardly by visual inspection and determined by spectrophotometry. This novel approach is simple, rapid, and sensitive.
Video resampling algorithm for simultaneous deinterlacing and image upscaling with reduced jagged edge artifacts
Authors: Yoo Du Sic , Chang Joonyoung , Park Chul Hee , Kang Moon Gi 
Published: December 2013

Abstract
In this paper, we propose a video resampling method for simultaneous deinterlacing and image upscaling. The proposed method is composed of two steps: the initial image magnification step and the edge enhancement step. In order to convert an interlaced image into a display format image, a filtering strategy, which resizes images with arbitrary ratios and reduces the overall computational load, is performed region adaptively using local characteristics such as motion or motionless regions. After the initial step, the proposed jagged edge correction (JEC) method is applied to the initially upscaled images to correct the stair-like artifacts (jagged edges) which are caused by ignoring any edge information in diagonal edge regions during the linear filtering process. Moreover, this method can be very useful for various upscaling applications to improve edge quality since it can be used in combination with other common interpolation techniques, such as cubic spline techniques. Experimental results show that the proposed method substantially reduces the jagged edges of the converted images and provides steep and natural-looking edge transitions.
Mandibular asymmetry: a three-dimensional quantification of bilateral condyles
Authors: Lin Han , Zhu Ping , Lin Yi , Wan Shuangquan , Shu Xin , Xu Yue , Zheng Youhua 
Published: December 2013

Abstract

Introduction
The shape and volume of the condyle is considered to play an important role in the pathogenesis of the mandibular deviation. Curvature analysis is informative for objectively assess whether the shape of the condyles matches that of the glenoid fossa. In this study, a three-dimensional (3-D) quantification of bilateral asymmetrical condyles was firstly conducted to identify the specific role of 3-D condylar configuration for mandibular asymmetry.

Methods
55 adult patients, 26 males (26 ± 5 yrs) and 29 females (26 ± 5 yrs), diagnosed with mandibular asymmetry were included. The examination of deviation of chin point, deviation of dental midlines, inclination of occlusal plane, and depth of the mandibular occlusal plane were conducted. After the clinical investigation, computed tomography images from the patients were used to reconstruct the 3-D mandibular models. Then the condylar volume, surface size, surface curvature and bone mineral density were evaluated independently for each patient on non-deviated and deviated sides of temporomandibular joint.

Results
Both the condylar surface size and volume were significantly larger on deviated side (surface size: 1666.14 ± 318.3 mm2, volume: 1981.5 ± 418.3 mm3). The anterior slope of the condyle was flatter (0.12 ± 0.06) and the posterior slope (0.39 ± 0.08) was prominently convex on the deviated side. The corresponding bone mineral density values were 523.01 ±118.1 HU and 549.07 ±120. 6 HU on anterior and posterior slopes.

Conclusions
The incongruence presented on the deviated side resulted in a reduction in contact areas and, thus, an increase in contact stresses and changes of bone density. All aforementioned results suggest that the difference existing between deviated and non-deviated condyles correlates with facial asymmetrical development. In mandibular asymmetry patients, the 3-D morphology of condyle on deviated side differ from the non-deviated side, which indicates the association between asymmetrical jaw function and joint remodeling.