bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does cognitive behaviour therapy for insomnia reduce clinical levels of fatigue, anxiety and depression in cancer patients?
Authors: Fleming Leanne , Randell Kate , Harvey Christopher‐James , Espie Colin A. 
Published: January 2014

AbstractObjectivesThis secondary analysis of data from a randomised controlled trial explores associations between common symptom clusters and evaluates pre‐treatment to post‐treatment changes in clinical levels of these symptoms following cognitive behaviour therapy for insomnia (CBT‐I).MethodsBaseline data from 113 participants with insomnia were explored to establish rates of and associations between clinical levels of fatigue, anxiety and depression across the sample. Effects of CBT‐I on this symptom cluster were also explored by examining changes in pre‐treatment to post‐treatment levels of fatigue, anxiety and depression.ResultsAt baseline, the most common symptom presentation was insomnia + fatigue, and 30% of the sample reported at least three co‐morbid symptoms. Post‐CBT, the number of those experiencing clinical insomnia and clinical fatigue decreased. There were no changes in anxiety rates from baseline to post‐treatment in the CBT group and modest reductions in rates of those with clinical depression. Seven individuals (9.6%) from the CBT group were completely symptom free at post‐treatment compared with 0% from the treatment as usual condition. Chi‐square analysis revealed a significant relationship between group allocation and changes in symptoms of insomnia and fatigue. No such relationship was found between group allocation and mood variables.ConclusionsThese findings confirm the high rate of symptom co‐morbidities among cancer patients and highlight strong associations between sleep and fatigue. CBT‐I appears to offer generalised benefit to the symptom cluster as a whole and, specifically, is effective in reducing fatigue, which exceeded clinical cut‐offs prior to implementation of the intervention. This has implications for the diagnosis/management of common symptoms in cancer patients. Copyright © 2014 John Wiley & Sons, Ltd.
Parenting stress as a mediator of parents' negative mood state and behavior problems in children with newly diagnosed cancer
Authors: van der Geest Ivana M. , van den Heuvel‐Eibrink Marry M. , Passchier Jan , van den Hoed‐Heerschop Corry , Pieters Rob , Darlington Anne‐Sophie E. 
Published: January 2014

AbstractObjectiveThe aim was to investigate the influence of parents' negative mood state and parenting stress on behavior in children with newly diagnosed cancer.MethodsA total of 123 parents (n = 58 fathers, n = 65 mothers) of 67 children with newly diagnosed cancer completed three questionnaires separately at the same time measuring parents' negative mood state, parenting stress, and child behavior problems.ResultsParents' negative mood state was weakly correlated to more child behavior problems (r = 0.31, p < 0.01), and higher levels of parenting stress were strongly correlated to more child behavior problems (r = 0.61, p < 0.01). Mediation analyses indicated that the relationship between parents' negative mood state and child behavior problems (c = 0.29, p = 0.02 (fathers); c = 0.25, p = 0.04 (mothers)) became non‐significant after mediating for parenting stress (c′ = 0.003, p = 0.98 (fathers); c′ = 0.10, p = 0.42 (mothers)). The indirect effect of parents' negative mood state and child behavior problems was only significant for fathers (95% CI [0.12; 0.51]), indicating that parenting stress mediates the effect between fathers' negative mood state and child behavior problems.ConclusionsThis is the first study to demonstrate the mediational role of parenting stress in fathers of a child with newly diagnosed cancer. Copyright © 2014 John Wiley & Sons, Ltd.
Exploring the contribution of psychosocial factors to fatigue in patients with advanced incurable cancer
Authors: Peters Marlies E. W. J. , Goedendorp Martine M. , Verhagen Stans A. H. H. V. M. , van der Graaf Winette T. A. , Bleijenberg Gijs 
Published: January 2014

AbstractObjectiveFatigue is the most frequently occurring and distressing symptom in patients with advanced cancer, caused by multiple factors. Neither a specific histological diagnosis of malignancy nor the type of anticancer treatment seem to be strongly related to fatigue, which support the idea that other factors may play a role. This study investigated to what extent the model of fatigue‐perpetuating factors that is known for cancer survivors was applicable for patients with advanced cancer.MethodsPatients on active treatment for various incurable cancers were asked to complete the Checklist Individual Strength, subscale fatigue severity and physical activity, the Acceptance scale of the Illness Cognition Questionnaire, the Hospital Anxiety and Depression Scale, the Fatigue Catastrophizing Scale, the Symptom Checklist subscale sleep, and the van Sonderen Social Support List‐Discrepancies.ResultsThe questionnaires were filled in by 137 patients. Inappropriate coping, fear of progression, fatigue catastrophizing, discrepancies in social support, depressive mood, self reported physical activity, and sleeping problems were all related to fatigue severity in univariate analyses, of which the latter two were significant in a multivariate linear regression analysis.ConclusionThis study tested fatigue‐perpetuating factors known to be of relevance in cancer survivors, for their relation with fatigue severity in palliative patients. We demonstrated that these factors were also relevant for patients on palliative treatment. On the basis of our results, we suggest clinicians confronted with palliative patients with serious fatigue to address sleeping problems and promote physical activity. In case of persistent fatigue, personalized cognitive behavioral therapy can be considered. Copyright © 2014 John Wiley & Sons, Ltd.
Fibronectin is a serum biomarker for Duchenne muscular dystrophy
Authors: Cynthia Martin F. , Hiller Monika , Spitali Pietro , Oonk Stijn , Dalebout Hans , Palmblad Magnus , Chaouch Amina , Guglieri Michela , Straub Volker , Lochmüller Hanns , Niks Erik H. , Verschuuren Jan J. G. M. , Aartsma‐Rus Annemieke , Deelder André M. , van der Burgt Yuri E. M. , 't Hoen Peter A. C. 
Published: January 2014

PurposeTo identify and validate serum biomarkers for the progression of Duchenne muscular dystrophy (DMD) using a MS‐based bottom‐up pipeline.Experimental designWe used a bottom‐up proteomics approach, including a protein concentration equalization step, different proteolytic digestions, and MS detection schemes, to identify candidate biomarkers in serum samples from control subjects and DMD patients. Fibronectin was chosen for follow‐up based on the differences in peptide spectral counts and sequence coverage observed between the DMD and control groups. Subsequently, fibronectin levels were determined with ELISA in 68 DMD patients, 38 milder Becker muscular dystrophy patients, 33 patients with other neuromuscular disorders, and 15 age‐matched adult and child controls.ResultsThere was a significant increase in fibronectin levels in DMD patients compared to age‐matched controls. Fibronectin levels in patients with Becker muscular dystrophy, Bethlem myopathy, or myasthenia gravis were comparable to control levels. Progressive elevation in fibronectin levels was observed in longitudinal samples from 22 DMD patients followed up for a period of 6 months up to 4 years.Conclusion and clinical relevanceThis study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in DMD patients.
Luminance and current distribution of hybrid circular GaN‐based resonant‐cavity light‐emitting diodes with lateral current injection on the n‐ and p‐side
Authors: Passow Thorsten , Kunzer Michael , Börner Paul , Pletschen Wilfried , Köhler Klaus , Wagner Joachim 
Published: January 2014

AbstractResonant‐cavity light‐emitting diodes emitting at around 400 nm based on an undoped bottom AlInN/GaN distributed Bragg reflector (DBR) and a top dielectric SiO2/ZrO2 DBR with circular emitting apertures of diameters ranging from 5 to 200 µm are demonstrated. The current distribution is investigated by luminance distribution imaging and three‐dimensional device simulations for different current densities. The current distribution exhibits a maximum in the aperture centre or is homogeneous up to an aperture diameter of 50 µm independent of the current density. A minimum occurs in the aperture centre for larger diameters increasing with increasing diameter and current density. The current distribution improves with larger n‐GaN thickness and higher contact resistance between the transparent In2O3:Sn (ITO) electrode and the p‐GaN contact layer. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Structural analysis of N‐polar AlN layers grown on Si (111) substrates by high resolution X‐ray diffraction
Authors: Pandikunta Mahesh , Ledyaev Oleg , Kuryatkov Vladimir , Nikishin Sergey A. 
Published: January 2014

AbstractCrack‐free high quality N‐polar AlN epitaxial layers were grown on Si (111) substrates by plasma‐assisted molecular beam epitaxy in the temperature range of 780–880 °C. The streaky 1×3 reflection high energy electron diffraction pattern was observed at room temperature for all AlN samples indicating N‐polarity of epilayers. The polarity of samples was also confirmed by KOH etching studies. Structural properties of as‐grown samples were carried out by high resolution X‐ray diffraction, scanning electron microscopy, and atomic force microscopy. The Williamson‐Hall plots of the rocking curves widths were employed in order to study the mosaicity, dislocation density, and level of stress as a function of growth temperature. The 250 nm thick AlN sample grown at 830 °C yields the best crystalline quality, smooth surface morphology, and smallest root mean square roughness. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Yield analysis of large‐area high‐power single‐chip GaN‐based light‐emitting diodes with network design
Authors: Wang Wei , Cai Yong , Zhang Yibin , Huang Hongjuan , Huang Wei , Li Haiou , Zhang Baoshun 
Published: January 2014

AbstractIn this Letter, a GaN‐based high‐power (HP) single‐chip (SC) large‐area LED with parallel and series network structure is fabricated. The optical characteristics of the HP‐SC LED is investigated. Driven at 600 mA, the optical output power of the HP‐SC LED chip is measured to be 9.7 W, corresponding to an EQE of 26.4%, which is 19.6% lower than that of the standard small LED cell due to both the lateral light‐extraction efficiency degradation and the self‐heating effect. A statistical analysis was carried out to investigate the yield of the fabricated HP‐SC LEDs, the experimental results agree with the theoretical calculations very well, validating the feasibility of this design on the production yield for the large‐area LEDs.magnified image(© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Ameliorative effect of polyphenols from Padina boergesenii against ferric nitrilotriacetate induced renal oxidative damage: With inhibition of oxidative hemolysis and in vitro free radicals
Authors: Rajamani Karthikeyan , Renju V. C. , Sethupathy S. , Thirugnanasambandan Somasundaram S. 
Published: January 2014

ABSTRACTThe aim of this study was to evaluate the antioxidant activities of diethyl ether (DEE) and methanol (M) extracts from brown alga Padina boergesenii using in vitro and in vivo antioxidant assay, which may help to relate the antioxidant properties with the possible outline of its ameliorative effect. M extract showed higher radical scavenging activity through ferric reducing antioxidant power 139.11 µmol tannic acid equivalent/g; DPPH 71.32 ± 0.56%; deoxyribose radical 88.31 ± 0.47%, and total antioxidant activity 0.47 ± 0.02 mg ascorbic acid equivalents/g. Oxidative red blood cell (RBC) hemolysis inhibition rate was significantly higher in M extract (150 mg/kg body weight) in reference to total phenolic content (r = 0.935). Rats administered with DEE and M extracts (150 mg/kg body weight) for seven days before the administration of ferric nitrilotriacetate (9 mg of Fe/mg/kg bodyweight). Rats pretreated with extracts significantly changed the level of renal microsomal lipid peroxidation, glutathione, and antioxidant enzymes in post‐mitochondrial supernatant (P < 0.05). Ameliorative effect of extracts against renal oxidative damage was evident in rat kidney through changes in necrotic and epithelial cells. HPTLC technique has identified the presence of rutin with reference to retardation factor (Rf) in both the extracts. These findings support the source of polyphenols (rutin) from P. boergesenii had potent antioxidant activity; further work on isolation of bioactive compounds can be channeled to develop as a natural antioxidant. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 865–876, 2015.
Effects of tetrabrombisphenol A on DNA integrity, oxidative stress, and sterlet (Acipenser ruthenus) spermatozoa quality variables
Authors: Linhartova Pavla , Gazo Ievgeniia , Shaliutina‐Kolesova Anna , Hulak Martin , Kaspar Vojtech 
Published: January 2014

ABSTRACTThe sperm of sterlet (Acispenser ruthenus) was used to investigate the effect of the xenobiotic tetrabrombisphenol A (TBBPA) on sperm quality variables (ATP content, spermatozoa motility, and velocity), DNA integrity, and oxidative stress indices. Sperm was diluted to obtain a spermatozoa density of 5 × 108 cells/mL and exposed for 2 h to final concentrations of TBBPA (0.5, 1.75, 2.5, 5, and 10 μg/L). The oxidative stress indices, including lipid peroxidation, carbonyl derivatives of proteins, and antioxidant activity were significantly higher with increased concentrations of TBBPA. There was significantly less intracellular ATP in sperm samples at TBBPA concentrations of 2.5 μg/L and above. Spermatozoa velocity and percent motile sperm were significantly lower at each sampling time post‐activation compared to controls. DNA damage expressed as percent DNA in Tail and Olive Tail moment was significantly higher with exposures ≥2.5 μg/L TBBPA. The results demonstrated that TBBPA and other xenobiotics can induce reactive oxygen species stress in fish spermatozoa, which could impair the sperm quality, DNA integrity, ATP content, and the antioxidant defense system. This study confirmed that fish spermatozoa can be used in in vitro assays for monitoring residual pollution in aquatic environments. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 735–745, 2015.
Fluoride‐induced apoptosis and expressions of caspase proteins in the kidney of carp (Cyprinus carpio)
Authors: Chen Jianjie , Cao Jinling , Wang Jundong , Jia Ruhui , Xue Wenjuan , Xie Lingtian 
Published: January 2014

ABSTRACTThe study was conducted to investigate oxidative stress, apoptosis, and protein expressions of caspase‐3, 8, and 9 in kidney of the carp juveniles exposed to 0, 40, 80, 120, and 160 mg L−1 of fluoride (in the form of NaF) for 90 days. The results showed that dose‐ and time‐dependent decrease of SOD and GSH and dose‐ and time‐dependent increase of MDA were observed in the carp juveniles, which suggested that fluoride induced oxidative damage accompanied with morphological changes and significant apoptosis in fish exposed to fluoride, especially in the higher doses. Fluoride exposure also significantly elevated the protein expressions of caspase‐3, 8, and 9. In conclusion, these results indicate that chronic exposure to fluoride causes oxidative stress, damages the kidney structure, and results in renal apoptosis by caspase‐dependent pathway. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 769–781, 2015.
Rhyolite–granite association in the Central Taimyr zone: evidence of accretionary-collisional events in the Neoproterozoic
Authors: Proskurnin V.F. , Vernikovsky V.A. , Metelkin D.V. , Petrushkov B.S. , Vernikovskaya A.E. , Gavrish A.V. , Bagaeva A.A. , Matushkin N.Yu. , Vinogradova N.P. , Larionov A.N. 
Published: January 2014

Abstract
The Central Taimyr accretionary belt includes two granite-metamorphic terranes: Faddey and Mamont-Shrenk, which include the oldest igneous formations of the Taimyr folded area in the Arctic framing of the Siberian craton—granitoids and granite-gneisses with U–Pb zircon ages of 900–830 Ma. The [FeO*/(FeO* + MgO)]-enriched granitoids of these terranes are products of highly fractionated I-type magmas. This paper presents results of new petrographic, geochemical, geochronological, and paleomagnetic investigations of acid rocks from a volcanic-plutonic association (in the region of the Leningradskaya River) in the Faddey terrane in the northeastern Taimyr area. These rocks formed during the final stage of continent–island arc accretion and collision that occurred at approximately 870–820 Ma. We established that the studied rocks belong to a long granitoid belt extending from Mamont-Shrenk to Faddey terrane, where all the igneous bodies are deformed and oriented uniformly. The paleomagnetic pole we calculated differs significantly from the apparent polar-wander path interval of corresponding age for Siberia. The 33.8°±5.4° angular distance between the poles indicates that the formation of this volcanic-plutonic association took place at a significant distance from the Taimyr margin of the Siberian paleocontinent.
Expression of 14-3-3 sigma, cyclin-dependent kinases 2 and 4, p16, and Epstein–Barr nuclear antigen 1 in nasopharyngeal carcinoma
Authors: Huang H-H , Chen C-H , Huang S-C , Yang C-H , Hwang C-F 
Published: January 2014

AbstractObjective:The protein 14-3-3 sigma plays a role in cell cycle arrest by sequestering cyclin-dependent kinase 1 cyclin B1 complexes, as well as cyclin-dependent kinases 2 and 4, hence its definition as a cyclin-dependent kinase inhibitor. However, the nature of the interaction between these biological markers in nasopharyngeal carcinoma is unknown. This study aimed to investigate whether altered expression of these markers contributes to nasopharyngeal carcinogenesis.Methods:The study population consisted of 30 nasopharyngeal carcinoma patients and 10 patients without nasopharyngeal carcinoma. The nasopharyngeal carcinoma cell lines TW02, TW04 and Hone-1 were also assessed. We analysed levels of messenger RNA and protein for the p16 gene and the 14-3-3 sigma, Epstein–Barr nuclear antigen 1, and cyclin-dependent kinase 2 and 4 proteins, in nasopharyngeal carcinoma tissue specimens and cell lines and in normal nasopharyngeal tissue.Results:Protein and messenger RNA levels for cyclin-dependent kinase 2 and Epstein–Barr nuclear antigen 1 were significantly higher in nasopharyngeal carcinoma compared with normal tissue, while levels of cyclin-dependent kinase 4 generally were not; results for 14-3-3 sigma varied. Nasopharyngeal carcinoma patients had diminished p16 gene expression, compared with normal tissue.Conclusion:Levels of cyclin-dependent kinase 2 and Epstein–Barr nuclear antigen 1 were significantly higher in nasopharyngeal carcinoma than in normal tissue, while p16 gene expression was diminished. These three proteins may contribute to nasopharyngeal carcinogenesis.
First bite syndrome: our experience of laser tympanic plexus ablation
Authors: Amin N , Pelser A , Weighill J 
Published: January 2014

AbstractIntroduction:First bite syndrome is a condition characterised by severe facial pain brought on by the first bite of each meal. This can severely affect the patient's ability to eat.Methods:We present a 70-year-old woman for whom we performed a laser ablation of the left ear tympanic plexus, as treatment of first bite syndrome. A permeatal approach was used to raise a tympanomeatal flap. The tympanic plexus was identified on the promontory and a 4 mm2 area of the plexus was ablated using CO2 laser. The flap was repositioned and a dressing was placed with topical antibiotics.Results:At two-month follow up, there was full resolution of the patient's symptoms.Discussion:First bite syndrome carries a high morbidity; treatment options are variable, and often unsuccessful. We describe the first documented case of laser tympanic plexus ablation, with a very effective initial response. This procedure represents a useful therapeutic option for first bite syndrome.
The presumption of consciousness
Authors: Evans Jonathan St. B. T. 
Published: January 2014

AbstractThroughout this article the authors presume – without justification – that decision making must be a conscious process unless proved otherwise, and they place an unreasonably strict burden of proof on anyone wishing to claim a role for unconscious processing. In addition, I show that their arguments do not, as implied here, impact upon contemporary dual-process theories of reasoning and decision making.
Dismissing subliminal perception because of its famous problems is classic “baby with the bathwater”
Authors: Finkbeiner Matthew , Coltheart Max 
Published: January 2014

AbstractNewell & Shanks (N&S) appeal to well-known problems in establishing subliminality to argue that there is little convincing evidence that subliminally presented stimuli can affect decision making. We discuss how recent studies have successfully addressed these well-known problems and, in turn, have revealed clear evidence that subliminally presented stimuli can affect decision making.
Context, as well as inputs, shape decisions, but are people aware of it?
Authors: Helzer Erik G. , Dunning David 
Published: January 2014

AbstractEven if people are experts at understanding how various input cues landed them at a particular decision (something the authors refer to as cue utilization), they may still fail to appreciate how context influences the weight given to those input variables. We review evidence suggesting that people are unaware of contextual influences on their decisions.
Restrictive and dynamic conceptions of the unconscious: Perspectives from moral and developmental psychology
Authors: Ingram Gordon P. D. , Prochownik Karolina 
Published: January 2014

AbstractNewell & Shanks' (N&S's) conceptualization of the unconscious is overly restrictive, compared to standard social psychological accounts. The dichotomy between distal and proximal cues is a weak point in their argument and does not circumvent the existence of unconscious influences on decision making. Evidence from moral and developmental psychology indicates that decision making results from a dynamic mixture of conscious and unconscious processes.
Better tests of consciousness are needed, but skepticism about unconscious processes is unwarranted
Authors: Ogilvie Ryan , Carruthers Peter 
Published: January 2014

AbstractWhat people report is, at times, the best evidence we have for what they experience. Newell & Shanks (N&S) do a service for debates regarding the role of unconscious influences on decision making by offering some sound methodological recommendations. We doubt, however, that those recommendations go far enough. For even if people have knowledge of the factors that influence their decisions, it does not follow that such knowledge is conscious, and plays a causal role, at the time the decision is made. Moreover, N&S fail to demonstrate that unconscious thought plays no role at all in decision making. Indeed, such a claim is quite implausible. In making these points we comment on their discussion of the literature on expertise acquisition and the Iowa Gambling Task.
Even “unconscious thought” is influenced by attentional mechanisms
Authors: Srinivasan Narayanan , Mukherjee Sumitava 
Published: January 2014

AbstractIn this commentary, we focus on the role of attentional mechanisms in unconscious thought. We argue that even distracted or unconscious thought is capacity limited and differences in scope of attention influence processing during unconscious thought. Attention also would influence processes at different stages in the proposed lens model. We conclude that there is a clear need to understand the role of attention to better understand conscious or unconscious thought.