bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compost amendment in urban gardens: elemental and isotopic analysis of soils and vegetable tissues
Authors: Trimmel Simone , Wagner Stefan , Feiner Laura , Feiner Maria , Haluza Daniela , Hood-Nowotny Rebecca , Pitha Ulrike , Prohaska Thomas , Puschenreiter Markus , Spörl Philipp , Watzinger Andrea , Ziss Elisabeth , Irrgeher Johanna 
Published: July 2024

AbstractUrban horticulture poses a sustainable form of food production, fosters community engagement and mitigates the impacts of climate change on cities. Yet, it can also be tied to health challenges related to soil contamination. This work builds on a previous study conducted on eleven urban gardens in the city of Vienna, Austria. Following the findings of elevated Pb levels in some soil and plant samples within that project, the present study investigates the elemental composition of soil and plants from two affected gardens 1 year after compost amendment. Inductively coupled plasma mass spectrometry (ICP-MS) analysis of skin, pulp and seeds of tomato fruits revealed minor variations in elemental composition which are unlikely to have an impact on food safety. In turn, a tendency of contaminant accumulation in root tips and leaves of radishes was found. Washing of lettuce led to a significant reduction in the contents of potentially toxic elements such as Be, Al, V, Ni, Ga and Tl, underscoring the significance of washing garden products before consumption. Furthermore, compost amendments led to promising results, with reduced Zn, Cd and Pb levels in radish bulbs. Pb isotope ratios in soil and spinach leaf samples taken in the previous study were assessed by multi-collector (MC-) ICP-MS to trace Pb uptake from soils into food. A direct linkage between the Pb isotopic signatures in soil and those in spinach leaves was observed, underscoring their effectiveness as tracers of Pb sources in the environment.
Graphical Abstract
Social risks assessment of the supply chain of an aluminium semi-finished profile for window
Authors: Di Giorgio Paolo , D’Eusanio Manuela , Serreli Monica , Petti Luigia 
Published: July 2024

Abstract
Purpose
Aluminium is among the most energy-intensive industries in the world and is produced from mining operations in bauxite mines. The effects on the environment of the entire aluminium supply chain, especially mining, also entail social risks. This article aims to understand the potential social risks along the supply chain of aluminium by focusing on a semi-finished frame for windows through the use of the Product Social Impact Life Cycle Assessment (PSILCA) database.

Method
Social Life Cycle Assessment (S-LCA) was implemented by following the Social Life Cycle Assessment of Products And Organizations 2020, to analyse the potential social risks and opportunities associated with the aluminium sector. Specifically, the PSILCA database, designed for S-LCA, was used to evaluate the background processes of the aluminium supply chain of an Italian company specialized in surface treatment of aluminium semi-finished products used in the production of doors and windows.

Results
The primary social risks manifest in the background processes. Comparing these findings with the literature review, it is straightforward to attribute them to the mining phase of bauxite, which constitutes the initial stage in aluminium production and occurs in various regions globally. Specifically, the highest social risk is associated with “Corruption in the public sector”, likely linked to Italy. Additionally, the study reveals a positive impact in terms of “Contribution to economic development” as also revealed by the literature review.

Conclusions
An analysis of the potential social risks within the aluminium supply chain was provided, addressing the research gap between the utilization of S-LCA methodology and its application within the sector. Additionally, the PSILCA database was employed for investigating the background processes in the case study. However, a social performance assessment using primary data would be required to enhance the representation of the evaluated production system.
Social life cycle assessment in current and future Norwegian livestock production
Authors: Møller Hanne , Rydhmer Lotta , Christensen Tove , Poulsen Lasse Krogh , Olsen Hanne Fjerdingby 
Published: July 2024

Abstract
Purpose
This study is a social life cycle assessment (S-LCA) of per capita consumption of animal protein in Norway in 2019. The animal protein consisted of milk, beef, pork, poultry and egg. Based on the 2019 results, two scenarios, TrendProd and ChangeProd, were qualitatively assessed. The TrendProd scenario is a continuation of the current trend towards highly efficient livestock production, whilst ChangeProd focuses on using livestock feed based on bioresources that are unsuitable for human consumption.

Methods
The assessment of current livestock production followed the updated version of the social LCA guidelines by UNEP (2020). A survey amongst stakeholders was conducted for the selection of subcategories. The product system was divided into the following steps: imported feed, domestic off-farm feed, livestock production, manufacturing, distribution and use. A total of 25 subcategories across six stakeholder groups (i.e. workers, local community, society, value chain actors, consumers and children) were included in the assessment. A reference scale approach was used with a scale from 1 to 4. The assessment included quantitative and qualitative data from statistics, indices, surveys, etc. The social performance of the scenarios was assessed by the authors’ expert evaluation using the Delphi approach, comparing performance of indicators relative to the current production.

Results and discussion
The life cycle for the current Norwegian livestock production had an acceptable or high social performance for 17 of the selected subcategories. Five subcategories had a low performance (fair salary, equal opportunities, animal welfare, food security, promoting social responsibility) and three had a very low performance (health and safety, cultural heritage, fair competition). The assessment of the scenarios indicated that anticipated improvements in skills and technology were key drivers for maintaining or enhancing social performance in certain subcategories. The use of activity variables for measuring the relative importance of each unit process is recommended as it reflects actual distribution and is consistent with the method of environmental LCA.

Conclusions
Overall, the social life cycle assessment of current livestock production demonstrated high social performance. A stakeholders’ survey resulted in a new subcategory, ‘food security’, which served to include societal concern for self-sufficiency and food security in social LCA. Limitations and uncertainties of the study have also been identified, some relating to data and choice of indicators and others to the application of method, e.g. activity variables, development of reference scale and aggregation of results.
Looking Toward the Future of Integrated Care: History, Developments, and Opportunities
Authors: Manderscheid Ronald W. , Ward Amy 
Published: July 2024

AbstractFor almost five decades, the development and implementation of integrated care—the simultaneous combination of primary care with mental health and substance use care—has been a major challenge for the behavioral health care field. Integrated care is exceptionally important because many people with behavioral health conditions also have chronic physical health conditions. Early research findings in the mid-1980s showed that persons with mental illness are likely to develop chronic physical conditions earlier and more severely than other people. These findings precipitated efforts to understand this problem and to develop further appropriate integrated care solutions. Subsequently, the US Surgeon General made care integration a major focus of his landmark 1999 Report on Mental Health, as did the 2008 Mental Health Parity and Addiction Equity Act and the 2010 Patient Protection and Affordable Care Act. However, it was not until 2014, and later, that integrated care actually began to be implemented more broadly. This article reviews these major developmental milestones, examines current activities, and explores likely developments over the next several years. Major current issues include the response to the COVID-19 pandemic, adjusting to its effects on the behavioral health care workforce, and the growing realization that behavioral health care must address the social determinants of life. Likely developments over the next several years will include devising ways to address our workforce crisis, developing effective community interventions, and implementing population health management strategies; implementing the CMS Innovation in Behavioral Health Model; improving reimbursement practices; and exploring the potential of AI for integrated care. Implications for future service organization and training of behavioral health care providers also are discussed. Granted the severity of the current workforce crisis in behavioral health care, urgent efforts are needed to advance the deployment of integrated care in the short-term future.
Informationssuchverhalten und digitale Gesundheitskompetenz von Schüler*innen in Deutschland während der Coronapandemie
Authors: László Emese , Sendatzki Saskia , Rathmann Katharina 
Published: July 2024

Zusammenfassung
Hintergrund
Während der Coronapandemie waren Schüler*innen mit einer Flut von Informationen zur Gesundheit und zur Coronapandemie konfrontiert. Der adäquate Umgang mit Gesundheitsinformationen setzt (digitale) Gesundheitskompetenz voraus. Ziel des Beitrags ist daher, das Informationssuchverhalten und das Ausmaß der digitalen Gesundheitskompetenz (dGK) von Schüler*innen in Deutschland während der Coronapandemie unter Berücksichtigung ihres sozialen Hintergrunds zu analysieren.

Material und Methoden
Die Online-Befragung wurde während des dritten Lockdowns, von März bis Juli 2021, in Hessen und anderen Bundesländern durchgeführt. Der Feldzugang erfolgte in weiterführenden Schulen, Verbänden und Sportvereinen. Der Online-Fragebogen wurde von N = 1096 Schüler*innen der Klassenstufe 6 bis 13 aufgerufen und n = 361 Schüler*innen vollständig ausgefüllt. Es wurden das gesundheitsbezogene Informationssuchverhalten (internetbasierte Quellen für Gesundheitsinformationen, [digitale] Quellen für Informationen zur Coronapandemie), die dGK (Digital Health Literacy Instrument [DHLI]) sowie soziodemografische und -ökonomische Hintergrundmerkmale (Geschlecht, Alter, zuhause gesprochene Sprache, Schulform, subjektiver Sozialstatus) erfasst und mittels uni-, bi- und multivariater Analysen mit SPSS ausgewertet.

Ergebnisse
Nach Gesundheitsinformationen zum Coronavirus im Internet suchten regelmäßig 75,6 % der Schüler*innen. Schwierigkeiten beim Umgang mit digitalen Gesundheitsinformationen gaben 52,6 % der Schüler*innen an. 49,8 % der Schüler*innen berichteten von Schwierigkeiten beim Bewerten der Zuverlässigkeit von digitalen Informationen zum Coronavirus. Die bi- und multivariaten Analysen weisen darauf hin, dass sich die dGK nach dem subjektiven Sozialstatus (SSS) dahingehend unterscheidet, dass Schüler*innen mit niedrigem bzw. mittlerem SSS (OR = 2,57, 95 %-KI: 1,30–5,06, p = 0,006) häufiger Schwierigkeiten im Umgang mit digitalen Gesundheitsinformationen zur Coronapandemie aufweisen als Gleichaltrige der Vergleichsgruppen. Die dGK unterscheidet sich nicht signifikant nach soziodemografischen (Geschlecht, Migrationshintergrund) und weiteren sozialen Merkmalen (besuchte Schulform, familiärer Wohlstand).

Schlussfolgerung
Die Förderung der dGK von Schüler*innen auf Schul- und Individualebene stellt ein wichtiges Anliegen der Prävention und Gesundheitsförderung dar. Durch bildungspolitische Maßnahmen (z. B. durch den „Medienkompetenzrahmen“ für die schulischen Medienbildung in den Bundesländern) sollte es den Schulen ermöglicht werden, die (d)GK im Rahmen der Medien- und Gesundheitsbildung in den Unterricht, Curricula und auf allen Ebenen von und bei allen Akteuren in Schulen (bspw. durch die organisationale Gesundheitskompetenz) zu berücksichtigen.
Progress in the Application of Hydrogels in Intervertebral Disc Repair: A Comprehensive Review
Authors: Chen Xin , Jing Shaoze , Xue Chenhui , Guan Xiaoming 
Published: July 2024

Abstract
Purpose of Review
Intervertebral disc degeneration (IVDD) is a common orthopaedic disease and an important cause of lower back pain, which seriously affects the work and life of patients and causes a large economic burden to society. The traditional treatment of IVDD mainly involves early pain relief and late surgical intervention, but it cannot reverse the pathological course of IVDD. Current studies suggest that IVDD is related to the imbalance between the anabolic and catabolic functions of the extracellular matrix (ECM). Anti-inflammatory drugs, bioactive substances, and stem cells have all been shown to improve ECM, but traditional injection methods face short half-life and leakage problems.

Recent Findings
The good biocompatibility and slow-release function of polymer hydrogels are being noticed and explored to combine with drugs or bioactive substances to treat IVDD.

Summary
This paper introduces the pathophysiological mechanism of IVDD, and discusses the advantages, disadvantages and development prospects of hydrogels for the treatment of IVDD, so as to provide guidance for future breakthroughs in the treatment of IVDD.
Oncogenic Gene CNOT7 Promotes Progression and Induces Poor Prognosis of Glioma
Authors: Lu Feng , Jiang Xiulong , Lin Kun , Zheng Pengfeng , Wu Shizhong , Zeng Guangming , Wei De 
Published: July 2024

AbstractGlioma is the most common malignant brain tumor in the central nervous system with the poor prognosis of patients. The CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is an important functional subunit of CCR4-NOT protein complex that has not been reported in glioma. In this study, we aimed to explore the function of CNOT7 in glioma. The TCGA (The Cancer Genome Atlas) and CGGA (Chinese Glioma Genome Atlas) databases were used for investigating the expression and survival condition of CNOT7 in glioma. The cellular function experiments of qRT-PCR, CCK-8 assays, wound healing assays, and Transwell assays were conducted to verify the function of knockdown CNOT7 in the glioma cell lines DBTRG and U251. Enrichment analysis was used to explore the molecular mechanism of CONT7 in glioma. What is more, the upstream regulation transcription factors of CNOT7 were analyzed based on the ChIP-Atlas and cBioportal (provisional) databases, and verified by the qRT-PCR and luciferase reporter assay. The CNOT7 was highly expressed in glioma and presented the poorer prognosis. The knockdown of CNOT7 inhibited the proliferation, migration, and invasion of glioma cell line, compared to control group. The enrichment analysis revealed that the CNOT7 participated in the development of glioma via G2M checkpoint, E2F targets, IL6-JAK-STAT3, and TNF-α signaling pathways via NF-κB. Besides, it was found that the HDAC2 (Human histone deacetylase-2) contributes to increased CNOT7 expression in glioma. The high-expressed CNOT7 is an oncogene with poor prognosis and participate the progression of glioma.
Arithmetic properties of l-regular partitions and l-regular bipartitions
Authors: Shruthi  , Kumar B. R. Srivatsa 
Published: July 2024

AbstractFor any positive integer l, let $$b_l(n)$$

b
l

(
n
)

and $$B_l(n)$$

B
l

(
n
)

represent the number of l-regular partitions and l-regular bipartitions respectively. By employing q-identities, we prove new congruences for $$b_{11}(n)$$

b
11

(
n
)

, $$b_{19}(n)$$

b
19

(
n
)

, $$b_{55}(n)$$

b
55

(
n
)

, $$B_{11}(n)$$

B
11

(
n
)

and $$B_{13}(n)$$

B
13

(
n
)

.
Teacher-Rated Mental Health of Siblings of Children with Chronic Disorders
Authors: Prentice Caitlin M. , Orm Stian , Botta Matteo , Vatne Torun M. , Fredriksen Trude , Kirchhofer Solveig , Fjermestad Krister 
Published: July 2024

AbstractSiblings of children with chronic disorders are at a heightened risk for internalizing and externalizing problems. Studies on sibling mental health typically use parent report, and sometimes sibling self-report, but do not include the perspectives of teachers. We investigated how teachers and parents in Norway rated sibling mental health to gain a more coherent picture of siblings’ well-being and functioning across the home and school contexts. We compared how siblings aged 8–16 years (45% boys, 54% girls) were scored on the strengths and difficulties questionnaire by teachers (n = 125), mothers (n = 115), and fathers (n = 81) with population norms and clinical cutoffs. For boys, the mean teacher scores did not indicate problems for total difficulties or any subscale except hyperactivity–inattention, but mean parent scores were higher for total difficulties and most subscales (d = .44 to .96). For girls, teachers indicated higher than norm scores for total difficulties, emotional problems, hyperactivity–inattention and peer problems (d = .26 to .46), while parents indicated higher total difficulties and problems across most subscales (d = .31 to .54). Prosocial behavior was as a relative strength of siblings across all raters. Siblings may not display the same level of mental health problems in school as at home, and teachers can offer an important perspective on siblings’ mental health and functioning.
Origin–destination matrices from smartphone apps for bus networks
Authors: Barabino Benedetto , Coni Mauro , Di Francesco Massimo , Obino Andrea , Ventura Roberto 
Published: July 2024

AbstractThe knowledge of passenger flows between each origin–destination (OD) pair is a main requirement in public transport for service planning, design, operation, and monitoring, and is represented by OD matrices. Although they can be determined by traditional approaches (e.g., surveys, ride-check counts, and/or smartcard-based methods), the availability of new technologies and the proliferation of portable devices triggers an emerging interest in building OD matrices from the apps of bus operators. This research proposes the first framework for the estimation of OD matrices on transit networks by processing smartphone app call detail records (SACDRs). The framework is experimentally tested on a sample of 30 workdays of an Italian bus operator. The results are represented by easy-to-read control dashboards based on maps, which help quantify and visualise the OD matrices in the metropolitan area of Cagliari (Italy). The experimentation shows that the framework can properly estimate the number of trips for both origin and destination w.r.t. OD matrices built from household surveys: the mean absolute error is on average lower than five movements for 90% of the origins and 85% of the destinations.
New data and insights on the secondary glass workshop of Comacchio (Italy): MgO contents, steatite crucibles and alternatives to recycling
Authors: Gliozzo Elisabetta , Braschi Eleonora , Ferri Margherita 
Published: July 2024

AbstractThis study introduces a collection of 33 glass samples, encompassing production indicators (blocks, fluidity tests, drops, cuts and wastes) and finished products (mainly goblets and probably a lamp) dating to the second half of the 7th century, except for a single more recent specimen (12th-14th). Additionally, a fragment was taken from a crucible bearing a thin layer of glass inside it. This new collection complements the investigation of glass materials from the Comacchio workshop previously analysed by Bertini et al. (2020).Measurements were performed using scanning electron microscopy, electron microprobe, laser ablation inductively coupled plasma mass spectroscopy on all samples and Sr–Nd isotopic analyses on 5 blocks.The results showed how the entire collection can be classified as natron-based silica-soda-lime glass and that the high MgO contents frequently observed are due to contamination with the steatite crucible. Contextually, the hypothesis of using plant ash-based glass mixed with natron-based glass formulated in the previous literature seems to have run out, along with the use of plant ash-based glass itself, further weakened by the very low representativeness of this latter type of glass on the site.The technological investigation further elucidated that recycling may not singularly account for the Comacchio glass technology. Discernible correlations may suggest the introduction of different types of metals, indicating a specialised control over the production process. Notably, the preference for green–blue glass emerges as a distinctive hallmark, underscoring the deliberate pursuit of a specific aesthetic taste.Lastly, the provenance analysis showed that over three-quarters of production was based on semi-finished products from Egypt, while only the remaining quarter came from the Levantine coast.
Evaluative Item-Contrastive Explanations in Rankings
Authors: Castelnovo Alessandro , Crupi Riccardo , Mombelli Nicolò , Nanino Gabriele , Regoli Daniele 
Published: July 2024

AbstractThe remarkable success of Artificial Intelligence in advancing automated decision-making is evident both in academia and industry. Within the plethora of applications, ranking systems hold significant importance in various domains. This paper advocates for the application of a specific form of Explainable AI—namely, contrastive explanations—as particularly well-suited for addressing ranking problems. This approach is especially potent when combined with an Evaluative AI methodology, which conscientiously evaluates both positive and negative aspects influencing a potential ranking. Therefore, the present work introduces Evaluative Item-Contrastive Explanations tailored for ranking systems and illustrates its application and characteristics through an experiment conducted on publicly available data.
Modulation of miR-155-5p signalling via 5-ASA for the prevention of high microsatellite instability: an in vitro study using human epithelial cell lines
Authors: Adamowicz Monika , Abramczyk Joanna , Kilanczyk Ewa , Milkiewicz Piotr , Łaba Alicja , Milkiewicz Malgorzata , Kempinska-Podhorodecka Agnieszka 
Published: July 2024

Abstract5-aminosalicylic acid (5-ASA) is a first-line treatment for maintaining colitis remission. It is a highly effective, safe, and well-tolerated drug with anti-inflammatory and chemo-preventive properties. While patients with primary sclerosing cholangitis (PSC) with concomitant ulcerative colitis are treated with 5-ASA, the molecular mechanisms underlying the drug’s chemo-preventive effects are not entirely understood. We previously reported that bile acids and lipopolysaccharide-induced miR-155 expression was associated with downregulating mismatch repair (MMR) proteins in CACO-2 cell lines. Therefore, in this investigation, a set of in vitro functional studies was performed to show the possible mechanisms behind the epigenetic relationship between miR-155 and 5-ASA’s prevention of high microsatellite instability (MSI-H). In transient transfection with miR-155Mimic, which behaves like endogenous miRNA, we confirmed the relationships between miR-155 and its target MMR in three human intestinal epithelial cell lines: CACO-2, NCM460D and HT-29. We have shown, for the first time, that 5-ASA modulates MLH1, MSH2, MSH6 in miR-155 transfected cells. These findings underline that chemoprotective 5-ASA therapy can effectively attenuate the expression of miR-155 and potentially prevent a development of MSI-H in a subset of colorectal cancers associated with PSC.