bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED: Chemotherapy Resistance in Diffuse-Type Gastric Adenocarcinoma Is Mediated by RhoA Activation in Cancer Stem-Like Cells
Authors: Yoon Changhwan , Cho Soo-Jeong , Aksoy Bülent Arman , Park Do Joong , Schultz Nikolaus , Ryeom Sandra W. , Yoon Sam S. 
Published: October 2015

Abstract
Purpose: The Lauren diffuse type of gastric adenocarcinoma (DGA), as opposed to the intestinal type (IGA), often harbors mutations in RHOA, but little is known about the role of RhoA in DGA.
Experimental Design: We examined RhoA activity and RhoA pathway inhibition in DGA cell lines and in two mouse xenograft models. RhoA activity was also assessed in patient tumor samples.
Results: RhoA activity was higher in DGA compared with IGA cell lines and was further increased when grown as spheroids to enrich for cancer stem-like cells (CSCs) or when sorted using the gastric CSC marker CD44. RhoA shRNA or the RhoA inhibitor Rhosin decreased expression of the stem cell transcription factor, Sox2, and decreased spheroid formation by 78% to 81%. DGA spheroid cells had 3- to 5-fold greater migration and invasion than monolayer cells, and this activity was Rho-dependent. Diffuse GA spheroid cells were resistant in a cytotoxicity assay to 5-fluorouracil and cisplatin chemotherapy, and this resistance could be reversed with RhoA pathway inhibition. In two xenograft models, cisplatin inhibited tumor growth by 40% to 50%, RhoA inhibition by 32% to 60%, and the combination by 77% to 83%. In 288 patient tumors, increased RhoA activity correlated with worse overall survival in DGA patients (P = 0.017) but not in IGA patients (P = 0.612).
Conclusions: RhoA signaling promotes CSC phenotypes in DGA cells. Increased RhoA activity is correlated with worse overall survival in DGA patients, and RhoA inhibition can reverse chemotherapy resistance in DGA CSC and in tumor xenografts. Thus, the RhoA pathway is a promising new target in DGA patients. Clin Cancer Res; 22(4); 971–83. ©2015 AACR.
Transthoracic Needle Biopsies: It's More than Just Hitting the Bull's-eye
Authors: Aerts Joachim G. 
Published: October 2015

Abstract
Spectroscopy has shown to be of value in determining benign from malignant tissue. Incorporation of spectroscopic measurements may increase the diagnostic yield of transthoracic needle biopsies. Given the increasing amount of incidentally found lung lesions, such a technique may prevent unnecessary invasive procedures and uncertainty for the patient. Clin Cancer Res; 22(2); 273–4. ©2015 AACR.
See related article by Spliethoff et al., p. 357
Abstract B45: c-MYC is a potential therapeutic target for cisplatin-resistant ovarian cancer
Authors: Vivas-Mejia Pablo E. , Reyes jeyshka , Sood Anil K. 
Published: October 2015

Abstract
Ovarian cancer accounts for approximately 3% of all cancers in women. However, it is the deadliest cancer of the female reproductive system. Due to its non-specific symptoms, ovarian cancer is diagnosed at advanced stages of the disease. The most common standard treatment for advanced ovarian cancer is the platinum-based drugs such as cisplatin. However, over 70% of women relapse due to chemoresistance. Several mechanisms of cisplatin resistance have been described. However, the exact mechanism is not known. Evidence indicates that activation of the transcription factor c-MYC and its regulated genes could be involved in such resistance. Furthermore, it has been found that there is a significant association between increasing c-MYC expression and poor survival. Our previous findings showed that c-MYC messenger (mRNA) levels were similar in a panel of resistant and sensitive ovarian cancer cells. However, cispaltin resistant cells expressed higher levels of c-MYC protein when compared to their sensitive counterparts. We found that specific microRNAs (miRNAs) could be involved in the post-transcriptional regulation of c-MYC in cisplatin resistant ovarian cancer cells. Importantly, targeting of c-MYC with small interference RNA (siRNA) in the cispaltin resistant ovarian cancer cells, A2780CP20 induced a significant cell growth arrest and inhibition of cell proliferation. These data suggests c-MYC as a potential therapeutic target for overcoming cisplatin resistance in ovarian cancer. Supported by: NIH-NCI 1K22CA166226-01A1 (PEVM), and the UPR-MDACC Partnership in Cancer Research Training Program.
Citation Format: Pablo E. Vivas-Mejia, jeyshka Reyes, Anil K. Sood. c-MYC is a potential therapeutic target for cisplatin-resistant ovarian cancer. [abstract]. In: Proceedings of the AACR Special Conference on Myc: From Biology to Therapy; Jan 7-10, 2015; La Jolla, CA. Philadelphia (PA): AACR; Mol Cancer Res 2015;13(10 Suppl):Abstract nr B45.
Abstract PR03: Serine 62 phosphorylated MYC associates with nuclear lamins and its regulation by CIP2A is essential for proliferation induction in vivo
Authors: Myant Kevin , Qiao Xi , Halonen Tuuli , Come Christophe , Laine Anni , Partanen Johanna I. , Ogg Erinn-Lee , Laiterä Tiina , Janghorban Mahnaz , Okkeri Juha , Klefström Juha , Sears Rosalie C. , Sansom Owen J. , Westermarck Jukka 
Published: October 2015

Abstract
Targeting MYC function would be highly desirable for hyperproliferative diseases. As MYC itself is refractory to direct chemical inhibition, understanding of the mechanisms determining MYC's transcriptional and proliferation promoting activities in vivo would be critical for generation of alternative targeting strategies. However, despite 30 years of research, it is very poorly documented what post-translational mechanisms control MYC function in vivo. Here we demonstrate for the first time that Lamin A/C association is critical for MYC phosphorylation regulation. MYC phosphorylation at serine 62 enhances MYC recruitment to Lamin A/C-associated nuclear structures and the Protein Phosphatase 2A (PP2A) inhibitor protein CIP2A is required for retaining this phosphorylation and localization. CIP2A is also critical for serum induced MYC phosphorylation, and for MYC-elicited proliferation induction in vitro. Critically, using complementary transgenic approaches, and intestinal regeneration model, we demonstrate the in vivo importance of this mechanism for MYC´s transcriptional and proliferation promoting activities. However, targeting of this mechanism does not influence basal proliferation, or differentiation of intestinal crypt cells or mouse well-being. Together we discover unprecedented importance of nuclear organization of MYC for its phosphorylation regulation; leading to in vivo demonstration of a strategy for targeting of MYC activity without detrimental physiological effects.
Citation Format: Kevin Myant, Xi Qiao, Tuuli Halonen, Christophe Come, Anni Laine, Johanna I. Partanen, Erinn-Lee Ogg, Tiina Laiterä, Mahnaz Janghorban, Juha Okkeri, Juha Klefström, Rosalie C. Sears, Owen J. Sansom, Jukka Westermarck. Serine 62 phosphorylated MYC associates with nuclear lamins and its regulation by CIP2A is essential for proliferation induction in vivo. [abstract]. In: Proceedings of the AACR Special Conference on Myc: From Biology to Therapy; Jan 7-10, 2015; La Jolla, CA. Philadelphia (PA): AACR; Mol Cancer Res 2015;13(10 Suppl):Abstract nr PR03.
Admirandus multicavus and Adoncholaimus ussuriensis sp. n. (Nematoda: Enoplida: Oncholaimidae) from the Sea of Japan
Authors: Mordukhovich Vladimir , Atopkin Dmitry , Fadeeva Natalia , Yagodina Victoria , Zograf Julia 
Published: October 2015

A description of one new, and redescription of one known, species of the subfamily Adoncholaiminae (Nematoda: Oncholaimidae) from Peter the Great Bay (Sea of Japan) are provided. Adoncholaimus ussuriensis sp. n. is characterised by relatively large body size (L = 4.3-5.8 mm in male, 4.4-6.2 mm in female), a pair of terminal pores of the Demanian system opening dorsally at 147-189 μm (2.3-3.0 abd) anterior to the anus, excretory pore located posterior to buccal cavity region, absence of a ventral swelling on tail, long spicules (190-230 μm), presence of a gubernaculum (32-40 μm), presence of a complicated sensory field in the male with a complex supplementary organ and two sets of pilose filaments (5-10 μm long) on the posterior cloacal lobe and four rows of subventral and subdorsal postcloacal sensilla. We provide a redescription of Admirandus multicavus illustrated by light and scanning electron micrographs and propose Adoncholaimus chinensis as a junior synonym of Admirandus multicavus. The diagnoses of both genera are emended. Partial sequences of the mitochondrial gene cytochrome oxidase c subunit I (COI) and D2-D3 region of the 28S rDNA for both species were obtained. A dichotomous key to Adoncholaimus species is provided.
Decentralizing for performance? A quantitative assessment of functional reforms in the German Länder
Authors: Ebinger Falk , Richter Philipp 
Published: October 2015

In the last 10 years, the governments of most of the German Länder initiated administrative reforms. All of these ventures included the municipalization of substantial sets of tasks. As elsewhere, governments argue that service delivery by communes is more cost-efficient, effective and responsive. Empirical evidence to back these claims is inconsistent at best: a considerable number of case studies cast doubt on unconditionally positive appraisals. Decentralization effects seem to vary depending on the performance dimension and task considered. However, questions of generalizability arise as these findings have not yet been backed by more ‘objective’ archival data. We provide empirical evidence on decentralization effects for two different policy fields based on two studies. Thereby, the article presents alternative avenues for research on decentralization effects and matches the theoretical expectations on decentralization effects with more robust results. The analysis confirms that overly positive assertions concerning decentralization effects are only partially warranted. As previous case studies suggested, effects have to be looked at in a much more differentiated way, including starting conditions and distinguishing between the various relevant performance dimensions and policy fields. Points for practitioners In multi-level systems, reformers of public administration have to decide which level is most appropriate for the implementation of a certain task. In the last years, reformers have often decided to decentralize state functions in the hope of creating an effective and efficient government. Yet, in reality, the claim to deliver public tasks better and, at the same time, cheaper in decentralized units proves unfeasible. We provide empirical evidence on the performance effects of decentralization and show that it has other advantages and other disadvantages compared to state service delivery. Reformers of public administration have to ponder these pros and cons in each particular case.
Reference interval for rectal temperature in healthy confined adult cats
Authors: Levy Julie K , Nutt Kelly R , Tucker Sylvia J 
Published: October 2015

Objectives: Despite the common use of rectal temperature for assessing health and identifying infectious diseases in cats, there is little evidence to support frequently cited feline reference intervals for rectal temperature. Body temperature measurements are most commonly performed indoors in animal shelters and veterinary clinics. In these facilities, cats are often inactive and housed in small enclosures in a climate-controlled environment. The purpose of this study was to establish a new reference interval for rectal temperature in healthy confined adult cats. Methods: Rectal temperatures were measured in 200 healthy adult indoor cats in animal shelters, veterinary clinics and private homes. The reference interval was established using the method of the Clinical and Laboratory Standards Institute. Results: The reference interval for healthy adult cat rectal temperature was determined to range from 36.7°C (confidence interval [CI] = 36.6–36.8°C; 98.1°F [CI = 97.9–98.3°F]) at the lower limit to 38.9°C (CI = 38.8–39.1°C; 102.1°F [CI = 101.9–102.3°F]) at the upper limit. The ambient temperature ranged from 20.3–30.8°C (68.5–87.5°F). Rectal temperature was not significantly correlated with ambient temperature. Conclusions and relevance: A range of 36.7–38.9°C (98.1–102.1°F) should be considered the new reference interval for healthy adult cats for rectal temperature measured indoors in climate-controlled conditions. This range is lower than commonly reported. Use of previously published ranges could lead to overdiagnosis of hypothermia or underdiagnosis of mild pyrexia.
Minireview: Familiar Faces in Unfamiliar Places: The Emerging Role of Nuclear Receptors in Lung Cancer
Authors: Yenerall Paul , Kittler Ralf 
Published: October 2015

AbstractNuclear hormone receptors (NRs) are a superfamily of 48 transcription factors that are frequently modulated by ligands and control various cancer-relevant cellular pathways, such as differentiation, proliferation, migration, and metabolism. These properties make them excellent therapeutic targets in cancers dependent upon their activity, and as such, 3 NRs, estrogen receptor-α, androgen receptor, and retinoic acid receptor-α (more specifically, the promyelocytic leukemia-retinoic acid receptor-α translocation), have been targeted clinically in breast cancer, prostate cancer, and acute promyelocytic leukemia, respectively. Recently, a number of studies have highlighted a putative role for NRs in nonsmall cell lung cancer (NSCLC), a highly lethal type of lung cancer with relatively few targeted agents. Here, we review the potential roles of selected NRs in NSCLC and offer insights on how NRs may be leveraged in NSCLC to improve patient outcomes.
Instability of periodic traveling waves for the symmetric regularized long wave equation
Authors: Pava Jaime Angulo , Brango Carlos Alberto Banquet 
Published: October 2015

AbstractWe prove the linear and nonlinear instability of periodic traveling wave solutions for a generalized version of the symmetric regularized long wave (SRLW) equation. Using analytic and asymptotic perturbation theory, we establish sufficient conditions for the existence of exponentially growing solutions to the linearized problem and so the linear instability of periodic profiles is obtained. An application of this approach is made to obtain the linear/nonlinear instability of cnoidal wave solutions for the modified SRLW (mSRLW) equation. We also prove the stability of dnoidal wave solutions associated to the equation just mentioned.
Impact of Point-of-Care Implementation in Pharmacist-Run Anticoagulation Clinics within a Community-Owned Health System: A Two-Year Retrospective Analysis
Authors: Challen Laura , Agbahiwe Sylvester , Cantieri Tara , Olivetti Jessica Garcia , Mbah Theophilus , Mendoza-Becerra Yvonne , Munoz Cesar , Nguyen Michelle , Partee Katashia , Lal Lincy , Thomas Jocelyn , Green Monica 
Published: October 2015

Background Point-of-care (POC) testing devices allow laboratory monitoring to be performed in various settings and accessed immediately. Objective To evaluate the outcomes of monitoring anticoagulation patients in pharmacistmanaged, multicenter clinics utilizing i-STAT POC machines. Methods This study was a retrospective, multicenter chart review of 150 patients before and after implementation of the POC intervention for anticoagulation monitoring. Data collected included international normalized ratio (INR) results, indication for warfarin, minor and major bleeds, thromboembolic events, emergency room (ER) visits, and hospitalizations before and after i-STAT POC implementation. Results The time in therapeutic INR range (TTR) was significantly higher after i-STAT POC implementation than before implementation (60.4% ± 21.2% and 52.5% ± 21.5%, respectively; P = .0001). There were no reports of major bleeding during the study period. Twenty-three minor bleeds were reported after i-STAT POC implementation compared to 19 events before implementation ( P < .0001). One thromboembolic event was reported after i-STAT POC implementation. There was a significant difference in the number of hospitalizations before i-STAT POC implementation as opposed to after implementation (2 and 0, respectively; P < .0001). There was also a significant increase in ER visits after i-STAT POC implementation ( P < .0001). Conclusion The results of the study indicate improvement in TTR in pharmacist-managed anticoagulation clinics by 7.8%. Although the use of the i-STAT POC machine detected an increase in minor bleeds, thromboembolic events, and ER visits, there was a decrease in hospitalization. The outcomes of this multicenter study indicate that implementation on this scale provides improvement in regard to safety and cost.
On Valid Signals in Joint Schemes for the Process Mean and Variance
Authors: Ralha Tânia , Morais Manuel Cabral , Oliveira M. Rosário 
Published: October 2015

Abstract
Joint schemes for the process mean and the variance are essential to determine if unusual
variation in the location and spread of a quality characteristic occurred.
This paper comprises a systematic study on the phenomena of misleading, unambiguous and simultaneous signals while dealing with Shewhart and EWMA joint schemes for the process mean and the variance of a normally distributed quality characteristic.
Examples have been added to illustrate how the R statistical software can be used to assess the performance of joint schemes in practice, namely when it comes to the occurrence of those valid signals.
Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction: clinical perspectives
Authors: Lovejoy David A. , Pavlović Téa 
Published: October 2015

Abstract
In humans, the teneurin gene family consists of four highly conserved paralogous genes that are the result of early vertebrate gene duplications arising from a gene introduced into multicellular organisms from a bacterial ancestor. In vertebrates and humans, the teneurins have become integrated into a number of critical physiological systems including several aspects of reproductive physiology. Structurally complex, these genes possess a sequence in their terminal exon that encodes for a bioactive peptide sequence termed the ‘teneurin C-terminal associated peptide’ (TCAP). The teneurin/TCAP protein forms an intercellular adhesive unit with its receptor, latrophilin, an Adhesion family G-protein coupled receptor. It is present in numerous cell types and has been implicated in gamete migration and gonadal morphology. Moreover, TCAP is highly effective at reducing the corticotropin-releasing factor (CRF) stress response. As a result, TCAP may also play a role in regulating the stress-associated inhibition of reproduction. In addition, the teneurins and TCAP have been implicated in tumorigenesis associated with reproductive tissues. Therefore, the teneurin/TCAP system may offer clinicians a novel biomarker system upon which to diagnose some reproductive pathologies.
Analysis of Compressor Surge in a Military Turbojet Engine: A Case Study
Authors: Mishra R. K. , Bhat R. Raghavendra , Chandel Sunil 
Published: October 2015

AbstractA case of compressor surge with bang noise during takeoff roll is investigated and presented in this paper. Fatigue failure of compressor rotor blades during takeoff is found to disturb the aerodynamics of compressor flow causing the surge. Based on evidences, failure of rotor blades and compressor surge due to over-speed and foreign object debris is ruled out. The paper presents the methodology adopted for the investigation and also suggests remedial measures necessary to prevent such incidents.
Explorations of Crystalline Effects on 4-(Benzyloxy)Benzaldehyde Properties
Authors: Harismah Kun , Ozkendir O. Murat , Mirzaei Mahmoud 
Published: October 2015

Abstract
The properties of 4-(benzyloxy)benzaldehyde (BBA), as a pharmaceutically important compound, have been investigated through the density functional theory (DFT) calculations. The properties of original crystalline and optimised gaseous structures have been evaluated to recognise the crystalline effects. In addition to the structural properties, nuclear magnetic resonance (NMR) properties have also been evaluated for both investigated systems to better detect the effects in atomic levels. The results indicated that the structural shape of BBA is significantly changed in the optimised gaseous system, showing significant crystalline effects on the geometrical positions. Moreover, the magnitudes for energies and dipole moments indicate notable effects on the electronic properties. The evaluated NMR properties also show that the atoms of aromatic systems detect significant changes more than the atoms of aliphatic systems in the investigated BBA. And finally, the oxygen bridge atom plays a dominant role in combining two benzene rings of BBA.
Hubungan Antara Fakta Norma, Moral, dan Doktrin Hukum Dalam Pertimbangan Putusan Hakim
Authors: Maggalatung A Salman 
Published: October 2015

Abstract: The Correlation among Facts, Norms, Moral and Legal Doctrine in Consideration of a Judge's Decision. A judge must be able to explore and understand the legal values ​​that live in the community, maintain their independence, applying legal norms with high moral, ethical and adhere to a code of professional conduct, attention to doctrine and the views of legal experts in making a decision. This research aims to identify and analyze the correlation between facts, norms, moral and legal doctrine in consideration of a judge's decision. In addition to knowing the scope of the relationship between the existing facts, norms should be used as the base, and how much influence a judge moral (law enforcement) in the decision and determination of the law. This study uses a qualitative-analysis-normative juridical and sociological-empirical. Abstrak: Hubungan Antara Fakta, Norma, Moral, dan Doktrin Hukum Dalam Pertimbangan Putusan Hakim. Seorang hakim harus mampu menggali dan memahami nilai-nilai hukum yang hidup dalam masyarakat, menjaga kemandiriannya, menerapkan norma hukum dengan moralitas yang tinggi, mematuhi etika dan kode etik profesi, memperhatikan doktrin dan pandanganpandangan para Ahli hukum dalam pengambilan sebuah putusan. Penulisan bertujuan untuk mengetahui dan menganalisis hubungan antara fakta, norma, moral, dan doktrin hukum dalam pertimbangan sebuah putusan hakim. Ruang lingkup tulisan ini meliputi hubungan antara fakta-fakta yang ada, norma-norma yang patut dijadikan dasar, dan seberapa besar pengaruh moral seorang hakim dalam pengambilan dan penetapan hukum. Metode yang digunakan kualitatifanalisis dengan pendekatan yuridis-normatif dan sosiologis-empiris. DOI: 10.15408/jch.v1i2.1462