bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conformity of Package Inserts Information to Regulatory Requirements
Authors: Deepika Gundavarapu Krishna , Lella Meenakshi , Sankar Kurli 
Published: July 2024

ABSTRACT

Background:
Accurate and reliable information regarding drugs is essential for safe and effective use of drugs. It is not possible for the clinician to refer research articles every time for complete updates. In such situations, package inserts (PIs) form an authentic information for the doctor and patient. The study was intended to assess the information completeness and precision of PIs using the criteria laid down by, sections 6.2 and 6.3 of Schedule D (II), Schedule Y of Drugs and Cosmetic Act (1940) and Rules (1945).

Materials and Methods:
PIs of different formulations were collected from various departments, and also local and regional chemists. The information adequacy was done by 25 checklist proposed by the Indian Drug and Cosmetic Act (1940) and Rules, 1945 under sections 6.2 and 6.3 of Schedule D and Schedule Y. A score of “1” was given, if information was present, and “0” if there was no information. Information adequacy scores also calculated.

Results:
A total of 207 PIs were analyzed. Majority of PIs belong Grade B category of drug information (174). Generic name, composition, posology and method of administration, undesirable effects, contraindications, drug interactions, special precautions, legibility, storage and contraindications during pregnancy and breast feeding were mentioned by nearly all. Gaps were observed in handling instructions, influence on person’s self-driving and machinery operation capabilities, pharmaceutical incompatibilities, shelf life, excipients and Pharmacokinetic and dynamic information not updated regularly.

Conclusion:
The current study shows that there is still inadequacy of particulars regarding drug information. Hence, it is essential to establish proper uniform standards for the currently available PIs. An absolute and flawless PI should provide complete information. This requires continuous and constant effort from manufacturer and regulatory authorities to promote safe and rational use of medicines.
Listener, member, and advisor perspectives regarding a pharmacy podcast student organisation
Authors: Wollen Joshua , Zhao Alexa , Rahimi Sama , Ganna Sourab , Nguyen Kimberly 
Published: July 2024

Background: This work describes the structure and function of a pharmacy student-led Podcast Student Organisation (PSO) through the perspectives of the organisation’s members, listeners, and advisors. It aims to provide a blueprint for other colleges of pharmacy to replicate and develop their own programmes and share the experiences of those involved with the PSO.
Methods: Perspectives from the advisors were gathered via statements. The listener and member perspectives were collected via a survey. Data were collected to share the listener and PSO member experience regarding the PSO.
Results: Based on the post-surveys meeting inclusion criteria (n = 32), most listeners showed statistically significant improvement in attitudes towards the topic of the episode (p = 0.027) and their college of pharmacy (p = 0.017). The podcast team showed statistical improvement in attitudes towards their college of pharmacy (p = 0.020) and their Doctor of Pharmacy curriculum (p = 0.046). Satisfaction responses were overwhelmingly positive after listening to the episodes.
Conclusion: The PSO may help improve attitudes towards some topics and promote positive feelings regarding students’ college. This description of the PSO and lessons learned may serve as a blueprint for colleges of pharmacy considering implementation and encourage others to adopt a PSO.
Comparison of Foley catheter and dinoprostone for labor induction in nulliparous women with Bishop’s score less than 5
Authors: Nguyen Thi Kim Anh 
Published: July 2024

Objectives: To compare Dinoprostone to Foley catheter as a cervical ripening method in primigravidae with Bishop’s score less than 5.
Materials and Methods: This study utilized a quasi-experimental research design to investigate the induction of labor in primigravidae with low Bishop’s score. The research was conducted at the Department of Obstetrics and Gynecology, Hospital of the Hue University of Medicine and Pharmacy from July 2022 to December 2023. Results: In comparison to the Foley group, Dinoprostone exhibited higher efficacy in cervical ripening (74.1% vs. 44.0%; p = 0.02). Dinoprostone was associated with a shorter time to delivery (13.92 hours vs. 29.67 hours; p < 0.05). The requirement for oxytocin augmentation was higher in the Foley group (72.0% vs. 7.4%, p < 0.05). The rate of vaginal delivery within 24 hours was higher in the Dinoprostone group (74.1% vs. 20.0%, p < 0.05). No differences were noted in the rates of overall vaginal delivery. Dinoprostone use was associated with a higher likelihood of uterine tachysystole (18.5% vs. 0.0%, p < 0.05), and the incidence of prelabor rupture of membranes during induction of labor was comparatively higher in this group (40.7% vs. 12.0%, p < 0.05).
Conclusions: Both labor induction methods, utilizing Foley and Dinoprostone in women with low Bishop scores (Bishop’s score < 5), demonstrate comparable effectiveness. The duration from induction of labor to the completion of labor is lengthier, and the need for oxytocin augmentation is greater in the Foley group. However, complications such as tachysystole and prelabor rupture of membranes during labor induction are more prevalent in the Dinoprostone group. The observed complications do not differ between the two groups.
Chromosomal abnormalities and Y chromosome microdeletions in patients with azoospermia and cryptozoospermia
Authors: Pham Chi Kong 
Published: July 2024

Purpose: To identify genetic abnormalities in patients with azoospermia and cryptozoospermia examined and treated at Da Nang Hospital for Women and Children.
Materials and Methods: A cross-sectional descriptive study was conducted at the Assisted Conception Unit, Da Nang Hospital for Women and Children from December 2020 to September 2023 including 72 cases of azoospermia and cryptozoospermia that met the inclusion and exclusion criteria and were included in the study. Results: The average age of the study subjects was 31.8±5.5 years old. The average duration of infertility was 3.8 ± 3.2 (years). There were ten cases of genetic abnormalities, accounted for 13.9% (10/72), of which three cases of chromosomal abnormalities accounted for 4.2% (3/72) and seven cases of Y chromosome microdeletions accounting for 9.7% (7/72). All cases of Y chromosome microdeletions have normal karyotypes. Of the three cases of chromosomal abnormalities, there were two cases of Klinefelter syndrome accounting for 2.8% and one case of chromosomal structural abnormality characterized by reciprocal translocation between the long arm of chromosome 9 and the short arm of chromosome 18 (46,XY,DER(9;18)(Q22;P11.3)). The rate of chromosomal polymorphism was 31.9%. The rate of Y chromosome microdeletions in the AZFc region was highest at 71.4%, of which 60% of the deletions in the AZFc region were gr/gr and 40% were b2/b4 deletions.
Conclusions: The genetic abnormalities in this study were similar to some studies in Asia and other regions around the world. Testing of karyotype and Y chromosome microdeletions is required in patients with azoospermia and cryptozoospermia.
Meningkatkan Kesehatan Mental Melalui Olahraga: Sebuah Penelitian Systematic Literature Review
Authors: Karim Naufal Nur Fadhillah Karim , Hambali Burhan Hambali 
Published: July 2024

Kesehatan mental sangatlah penting dalam kehidupan manusia untuk menjalankan aktivitas sehari-hari. Tujuan penelitian ini adalah untuk mengetahui manfaat olahraga dalam meningkatkan kesehatan mental berdasarkan sistematik litelatur review. Penelitian menggunakan metode Systematic Literature Rewiew (SLR). Database yang digunakan untuk mencari literatur merupakan data yang terdapat pada website Google Schoolar. Hasil penelitian disajikan dengan melihat kualitas dokumen secara detail dan sesuai ruang lingkup penelitian. Terdapat 6 artikel relevan dari 25 artikel terkait. Berdasarkan hasil pencarian yang sesuai tahapan Preferred Reporting Items for Systematic Review and MetaAnalyses (PRISMA) bahwa dengan berolahraga dapat meningkatkan kesehatan mental. Jenis dokumen yang di cari dalam penelitian ini merupakan dokumen dengan rentang waktu 10 tahun terakhir yang terbit pada jurnal nasional terindex sinta dan dapat diakses secara terbuka. Berdasarkan hasil dan pembahasan, kesimpulan penelitian ini mengemukakan bahwa olahraga dapat meningkatkan kesehatan mental.
Analisis Penggunaan Alat Bantu dan Teknik Gerak dalam Permainan Tradisional sebagai Bagian dari Kurikulum Olahraga di SDN Rembang 2 Kabupaten Kediri
Authors: Naufal Bima Wicaksana  , Herpandika Reo Prasetiyo Herpandika , Harmono Setyo Harmono 
Published: July 2024

Masuknya permainan tradisional ke dalam kurikulum olahraga sekolah dasar menjadi semakin penting. Keterlibatan yang lebih besar dalam kegiatan fisik dan teknologi telah mengurangi keterlibatan anak-anak dalam permainan tradisional. Permainan tradisional sangat penting untuk perkembangan fisik dan sosial mereka. Oleh karena itu, analisis menyeluruh tentang teknik gerak dan penggunaan alat bantu dalam permainan tradisional di sekolah dasar sangat penting. Jenis penelitian ini yaitu deskriptif dengan pendekatan kuantitatif. karena penelitian ini disajikan dengan menggunakan angka-angka. Sedangkan sampel dalam penelitian ini adalah siswa kelas 4, 5 dan 6 yang berjumlah 42 siswa. Instrumen yang digunakan untuk menilai penggunaan alat bantu, teknik gerak, kerjasama tim dan keselamatan dalam bermain permainan tradisional. Berdasarkan hasil penelitian tersebut, dapat disimpulkan bahwa keseluruhan penggunan alat bantu dan teknik gerak dalam 5 permainan tradisional. Dari data yang sudah dianalisis, terlihat bahwa mayoritas siswa menilai penggunaan alat bantu dan teknik gerak dalam permainan tradisional berada pada kategori baik (64%) dan sangat baik (15%). Ini menunjukkan bahwa implementasi alat bantu dan teknik gerak dalam permainan tradisional dinilai cukup efektif dan berkualitas oleh siswa, dengan sedikit ruang untuk perbaikan menuju kategori sangat baik.
ANALISIS TINGKAT MISKONSEPSI SISWA MAN BINJAI PADA MATERI SUHU DAN KALOR MENGGUNAKAN THREE-TIER MULTIPLE CHOICE DIAGNOSTIK TEST
Authors: Suhaila Aninda , Sani Ridwan Abdullah , Azhar Zul 
Published: July 2024

Pengembangan Three-Tier Multiple Choice Diagnostik Test untuk Mengetahui Tingkat Miskonsepsi Siswa SMA/MA Pada Materi Suhu dan Kalor.Penggunaan instrumen tes three-tier multiple choice diagnostik test dapat mengetahui tingkat miskonsepsi siswa. Penelitian dan pengembangan ini bertujuan untuk mengetahui tingkat miskonsepsi siswa pada materi suhu dan kalor. Penelitian ini merupakan penelitian R&D dengan model pengembangan 4D. Penelitian ini menggunakan 3 orang validator dan subjek penelitian 30 siswa/i di kelas XII MIA 2 MAN Binjai.Metode analisis data validitas dengan menggunakan koefisien korelasi biserial pada soal pilihan berganda dan uji reliabilitas menggunakan KR-20. Persentase siswa yang mengalami miskonsepsi terbanyak 27 siswa sebesar 90% pada butir soal 10. Persentase rata-rata siswa mengalami miskonsepsi sebesar 58,2%. Berdasarkan hasil yang diperoleh, instrumen tes three-tier multiple choice diagnostik test yang dikembangkan efektif untuk mengetahui tingkat miskonsepsi yang dialami siswa pada materi suhu dan kalor sehingga soal dapat disebarkan.
Analisis Korelasi Produktivitas Padi Metode NDVI Dengan Data Ubinan Di Kabupaten Sukoharjo
Authors: Sekarsih Fitria , Fajar Kusuma Guntur 
Published: July 2024

Padi merupakan salah satutanaman pangan utama bagi mayoritas penduduk dunia. Sekitar 98% masyarakat Indonesia mengkonsumsi beras. Ketersediaan beras harus dijaga karena memiliki dampak yang besar bagi ketahanan pangan maupun perekonomian. Data tentang hasil padi dapat digunakan untuk memantau kestabilan produksi padi secara berkala. Data estimasi hasil panen dibutuhkan oleh departemen pertanian atau instansi terkait untuk mengatur perdagangan maupun kebutuhan padi. Estimasi produksi padi biasanya dilakukan dengan cara tradisional yang memerlukan biaya, tenaga, dan waktu yang banyak sehingga tidak efisien apabila digunakan untuk perencanaan atau pengambilan keputusan yang membutuhkan tindakan cepat. Data Penginderaan jauh dapat memberikan informasi dalam penyajian tabular maupun spasial dengan cepat dan akurat. Citra satelit dapat digunakan untuk estimasi hasil padi dengan metode indeks spektral yaitu indeks vegetasi seperti Normalized Difference Vegetation Index (NDVI). Indeks NDVI dapat digunakan untuk mendeteksi kandungan klorofil pada tanaman yang selanjutnya digunakan untuk estimasi hasil padi. Estimasi cepat ini kemudian akan dikorelasikan dengan data ubinan padi di Kabupaten Sukoharjo sehingga menghasilkan persamaan y=6,2212x+6,7444, dimana y adalah produktivitas padi dan x adalah nilai NDVI. Hasil estimasi produktivitas padi memiliki simpangan rata-rata terhadap produktivitas padi data ubinan sebesar +0,32 dengan RMSE total 0,446329. Persamaan tersebut juga dapat diaplikasikan pada tahun lain dari perekaman citra bulan September di Kabupaten Sukoharjo.
The use of a complex of microorganisms in yogurt production technology
Authors: Smirnova E. S. , Razhina E. V. , Lopayeva N. L. , Khairova I. M. , Sinko V. N. , Stakheeva L. M. , Shilovtsev A. V. 
Published: July 2024

Fermented milk products are one of the most common foods among the population. This category of products includes yogurt, which is available in its various variations: with different acidity concentrations, with various additives, and different fat content. The article presents the results of studies on the influence of a complex of microorganisms on the quality indicators of yogurt (organoleptic, physicochemical). The purpose of the research was to study the effect of different volumes of symbiotic starter on the quality indicators of yogurt. The research was carried out in the laboratory of the Department of Biotechnology and Food Products of the Ural State Agrarian University.The Methods. Four yogurt samples were produced and analyzed: a control sample and three experimental ones. The finished products were assessed for organoleptic characteristics and mass fraction of protein (GOST 31981-2013). Acidity was set according to GOST 31976-2012.The Results. According to experts, sample No. 2 was recognized as the best, with a total volume of the complex of microorganisms of 70 ml per 150 g of the finished product. This sample had a uniform consistency, undisturbed clot, and no whey separation was observed; taste and smell – pure, fermented milk; color – milky white. All test samples had deviations in the protein mass fraction. Thus, in sample No. 1, MDB was 3.4%, in samples No. 2 and No. 3 – 3.6 and 3.8%. The obtained indicators were higher than the standard values by 0.2, 0.4 and 0.6%, respectively. Acidity in all samples was within normal limits.The Conclusion. Yogurt, with a complex of microorganisms can expand the line of functional products, and the addition of symbiotic starters will improve the properties of the product and classify it as functional.
Simulation of the process of cryogenic freezing of coriander seeds
Authors: Sterekhova N. V. , Meretukov Z. A. , Gonezhuk S. Y. , Shishova R. G. 
Published: July 2024

In the technology for extracting the required components from plant raw materials, in most cases, the grinding process is used as a preparatory operation before the main process, followed by the separation of the extracted material into target components.In most cases, as a result of such a process, we can talk about the effective extraction of only a single target component, while others inevitably lose their qualitative and quantitative indicators, which is due to the morphology of the plant raw material.One of the promising directions in the processes of destruction of plant material for further operations is selective disintegration. For this purpose optimal process conditions have been selected, such as heating, freezing and others. Raw materials obtained as a result of selective destruction can be effectively fractionated according to morphological and physicochemical characteristics, and only after that can be sent to subsequent operations with the greatest efficiency.Under modern conditions, the loss of essential oil in coriander associated with splitting the fruit reaches 23.4% of the oil weight in whole fruits. At the same time, the essential oil from split fruits is enriched with valuable components – linalool, geraniol, geranyl acetate and, in addition, contains less hydrocarbons and camphor. As shown in [1], oil from split fruits can be used to adjust the composition of batches of coriander essential oil in order to increase the content of linalool while simultaneously reducing the content of undesirable components – hydrocarbons and camphor, and can also be used primarily to isolate valuable components – linalool, geraniol. To reduce losses associated with splitting coriander fruits, it has been proposed to carry out mathematical modeling of the process of cryogenic freezing with subsequent grinding of the frozen mass, which will significantly reduce losses of essential oil. Considering that essential oils extracted from coriander show high antibacterial, antioxidant and antifungal activity [2], increasing the yield of high-quality coriander essential oil will allow its wider use in flavoring and food preservation, as well as for medicinal purposes, which is important and actual task.
Study of biologically active substances of plants of the North-West Caucasus that produce a sedative effect
Authors: Stalnaja M. I. , Sichko N. O. 
Published: July 2024

Medicinal plants have always arised an interest because they usually have pharmacological effects, low toxicity and high safety. Herbal preparations can be used both for the prevention of certain diseases and for the treatment of chronic and slowly developing ones. At the same time, practically healthy people can also use them to improve their quality of life. The experience of using medicinal plants in traditional medicine in the North-West Caucasus (in particular, in the Republic of Adygea) contributed to their active study with the aim of introducing official scientific medicine into clinical practice.For the treatment, prevention and diagnosis of many diseases, the medications are widely used that have a sedative effect in various neurotic conditions and have a regulatory effect on the central nervous system, reducing excitatory processes, enhancing inhibitory processes or eliminating the consequences of stressful situations. In this regard, there is a need to expand the local raw material base of medicinal plants, which accumulate biologically active substances in high concentrations.The article provides data on the study of wild North Caucasian populations of medicinal plants (valerian officinalis, common hop, motherwort and peppermint), which are promising producers of biologically active compounds. The results obtained indicate the safety of the raw material, allow us to evaluate its quality and prove the promise of ongoing scientific research, which has not only theoretical but also practical significance for the purpose of creating drugs that have a sedative effect, as well as for processing without restrictions.
Revisiting the relationship between the principle of benevolence and beneficence
Authors: Stenishcheva A. A. 
Published: July 2024

The relevance of the research is substantiated by the fact that the principles of the educational process are almost always interconnected in their essence. However, usually a separate principle is taken as a basis, while establishing the relationship between the principles of benevolence and beneficence contributes to a much deeper understanding of the dialectics of educational interactions.The problem statement: without a sense of benevolence and beneficence, learners are less likely to be interested in thinking and acting in ways that meet the needs of others.The goal of the research is to analyze contemporary literature to identify the relationship between the principle of benevolence and beneficence, which should encourage young people to know about the lives of other people and specific circumstances.The object of research is the principles of benevolence and beneficence as humanitarian prerequisites for the moral process, and the subject is the education of the individual on this basis.The research method is conceptual analysis. A detailed examination of the presented concepts, which forms a clear idea of their essence and content, deserves special attention in this work.The conclusions: in order to understand what exactly contributes to the formation of a basis for familiarity with different points of view and worldviews, as well as with the structural causes of social problems and the potential consequences of actions taken to solve them, aspects for the emergence of these principles were considered. Also, during a detailed study of materials devoted to this issue, the principle of justice and charity has been discovered and described in the context of the connection between benevolence and beneficence. It has been noted that the use of the principle of benevolence and beneficence, considering age characteristics, can become one of the foundations in determining the mechanisms for implementing the continuity of teacher education.The results of the study can be used not only in training teachers, but can also be useful for specialists in the field of psychology, culture, etc.
Mapping as a means of developing cognitive competence of university students
Authors: Shelekhova L. V. , Brantova F. S. 
Published: July 2024

The relevance. The introduction of digital technologies into the professional sphere has predetermined an increase in the amount of information necessary for successful development in professional activities. This fact involves the development of students’ skills in searching, analyzing, systematizing and mastering educational material.The problem statement: how can the interaction of visual and non-modal channels of information perception be optimized so that the process of searching, analyzing, systematizing and assimilating professionally significant information among higher school students becomes effective?The goal of the research is to substantiate the effectiveness of using mapping as a means of developing skills in searching, analyzing, systematizing and assimilating professionally significant information in the process of educational activities.The following methods of empirical research were used: questionnaires based on Google forms, conversation and testing, T-Test. The experiment involved students and teachers of Kuban and Adyghe State Universities.The results of the research consist in clarifying the content of the concept of «visualization», establishing the relationship between the purpose of using mapping and the educational result, identifying the potential of mapping in increasing the efficiency of search, analysis, systematization and assimilation of educational material.Key conclusions: The introduction of mapping into the educational process contributes to improving the perception of information through visualization of the material being studied and the introduction of a «clip» method of demonstrating information; optimizing time when learning new material due to the structure of educational information; increasing involvement in the educational process due to the optimal combination of visualization of the artistic attractiveness of the map design and the structural and logical diagram of the information being studied in one didactic toolkit.