bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laplace inversion of low‐resolution NMR relaxometry data using sparse representation methods
Authors: Berman Paula , Levi Ofer , Parmet Yisrael , Saunders Michael , Wiesman Zeev 
Published: May 2013

ABSTRACTLow‐resolution nuclear magnetic resonance (LR‐NMR) relaxometry is a powerful tool that can be harnessed for characterizing constituents in complex materials. Conversion of the relaxation signal into a continuous distribution of relaxation components is an ill‐posed inverse Laplace transform problem. The most common numerical method implemented today for dealing with this kind of problem is based on L2‐norm regularization. However, sparse representation methods via L1 regularization and convex optimization are a relatively new approach for effective analysis and processing of digital images and signals. In this article, a numerical optimization method for analyzing LR‐NMR data by including non‐negativity constraints and L1 regularization and by applying a convex optimization solver PDCO, a primal‐dual interior method for convex objectives, that allows general linear constraints to be treated as linear operators is presented. The integrated approach includes validation of analyses by simulations, testing repeatability of experiments, and validation of the model and its statistical assumptions. The proposed method provides better resolved and more accurate solutions when compared with those suggested by existing tools. © 2013 Wiley Periodicals, Inc. Concepts Magn Reson Part A 42A: 72–88, 2013.
A multi‐institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer
Authors: Kim Edward J. , Ben‐Josef Edgar , Herman Joseph M. , Bekaii‐Saab Tanios , Dawson Laura A. , Griffith Kent A. , Francis Isaac R. , Greenson Joel K. , Simeone Diane M. , Lawrence Theodore S. , Laheru Daniel , Wolfgang Christopher L. , Williams Terence , Bloomston Mark , Moore Malcolm J. , Wei Alice , Zalupski Mark M. 
Published: May 2013

BACKGROUNDThe purpose of this study was to evaluate preoperative treatment with full‐dose gemcitabine, oxaliplatin, and radiation therapy (RT) in patients with localized pancreatic cancer.METHODSEligibility included confirmation of adenocarcinoma, resectable or borderline resectable disease, a performance status ≤2, and adequate organ function. Treatment consisted of two 28‐day cycles of gemcitabine (1 g/m2 over 30 minutes on days 1, 8, and 15) and oxaliplatin (85 mg/m2 on days 1 and 15) with RT during cycle 1 (30 Gray [Gy] in 2‐Gy fractions). Patients were evaluated for surgery after cycle 2. Patients who underwent resection received 2 cycles of adjuvant chemotherapy.RESULTSSixty‐eight evaluable patients received treatment at 4 centers. By central radiology review, 23 patients had resectable disease, 39 patients had borderline resectable disease, and 6 patients had unresectable disease. Sixty‐six patients (97%) completed cycle 1 with RT, and 61 patients (90%) completed cycle 2. Grade ≥3 adverse events during preoperative therapy included neutropenia (32%), thrombocytopenia (25%), and biliary obstruction/cholangitis (14%). Forty‐three patients underwent resection (63%), and complete (R0) resection was achieved in 36 of those 43 patients (84%). The median overall survival was 18.2 months (95% confidence interval, 13–26.9 months) for all patients, 27.1 months (95% confidence interval, 21.2–47.1 months) for those who underwent resection, and 10.9 months (95% confidence interval, 6.1–12.6 months) for those who did not undergo resection. A decrease in CA 19‐9 level after neoadjuvant therapy was associated with R0 resection (P = .02), which resulted in a median survival of 34.6 months (95% confidence interval, 20.3–47.1 months). Fourteen patients (21%) are alive and disease free at a median follow‐up of 31.4 months (range, 24–47.6 months).CONCLUSIONSPreoperative therapy with full‐dose gemcitabine, oxaliplatin, and RT was feasible and resulted in a high percentage of R0 resections. The current results are particularly encouraging, because the majority of patients had borderline resectable disease. Cancer 2013;119:2692–2700. © 2013 American Cancer Society.
Pronecrotic mixed lineage kinase domain‐like protein expression is a prognostic biomarker in patients with early‐stage resected pancreatic adenocarcinoma
Authors: Colbert Lauren E. , Fisher Sarah B. , Hardy Claire W. , Hall William A. , Saka Burcu , Shelton Joseph W. , Petrova Aleksandra V. , Warren Matthew D. , Pantazides Brooke G. , Gandhi Khanjan , Kowalski Jeanne , Kooby David A. , El‐Rayes Bassel F. , Staley Charles A. , Adsay N. Volkan , Curran Walter J. , Landry Jerome C. , Maithel Shishir K. , Yu David S. 
Published: May 2013

BACKGROUNDMixed lineage kinase domain‐like protein (MLKL) is a necrosome component mediating programmed necrosis that may be an important determinant of cancer cell death. The goal of the current study was to evaluate the prognostic value of MLKL expression in patients with pancreatic adenocarcinoma (PAC).METHODSTissue from 80 patients was collected from a prospectively maintained database of patients with PAC who underwent pancreaticoduodenectomy between January 2000 and October 2008. Immunohistochemistry analysis was performed and scored using an established scoring system. Kaplan‐Meier survival curves were generated for recurrence‐free survival (RFS) and overall survival (OS) for all patients and for patients receiving adjuvant chemotherapy. MLKL scores were correlated with RFS and OS using univariate and multivariate Cox regression analyses incorporating clinically relevant covariates.RESULTSThe median age of the patients was 63 years and 53% were men. Low MLKL expression was associated with decreased OS (6 months vs 17 months; P = .006). In the subset of 59 patients who received adjuvant chemotherapy, low MLKL expression was associated with decreased RFS (5 months vs 15 months; P = .006) and decreased OS (6 months vs 19 months; P < .0001). On multivariate analysis, low MLKL expression was associated with poor OS in all patients (hazards ratio, 4.6 [95% confidence interval, 1.6‐13.8]; P = .006) and in patients receiving adjuvant chemotherapy (hazards ratio, 8.1 [95% confidence interval, 2.2‐29.2]; P = .002).CONCLUSIONSLow expression of MLKL is associated with decreased OS in patients with resected PAC and decreased RFS and OS in the subset of patients with resected PAC who receive adjuvant chemotherapy. The use of this biomarker in patients with PAC may provide important prognostic information. Cancer 2013;119:3148–3155. © 2013 American Cancer Society.
Relationship between 6‐ and 9‐month progression‐free survival and overall survival in patients with metastatic urothelial cancer treated with first‐line cisplatin‐based chemotherapy
Authors: Galsky Matthew D. , Krege Susan , Lin Chia‐Chi , Hahn Noah , Ecke Thorsten , Moshier Erin , Sonpavde Guru , Godbold James , Oh William K. , Bamias Aristotle 
Published: May 2013

BACKGROUNDUse of progression‐free survival (PFS) as a clinical trial endpoint in first‐line treatment of patients with metastatic urothelial carcinoma (UC) is attractive, but would be enhanced by establishing a correlation between PFS and overall survival (OS).METHODSData was pooled from 7 phase 2 and 3 trials evaluating cisplatin‐based chemotherapy in metastatic UC. An independent cohort of patients enrolled on a phase 3 trial was used for external validation. Landmark analyses for progression at 6 and 9 months after treatment initiation were performed to minimize lead‐time bias. A proportional hazards model was used to assess the utility of PFS for predicting OS.RESULTSA total of 364 patients were included in the initial cohort. The median PFS was 8.21 months (95% confidence interval = 7.43, 8.39) and the median OS was 13.50 months (95% confidence interval = 11.80, 15.67). In the landmark analysis, the median OS for patients who progressed at 6 months was 3.87 months compared with 15.06 months for those patients who did not progress (P < .0001) and the median OS for patients who progressed at 9 months was 5.65 months compared with 21.39 months for those patients who did not progress (P < .0001). A Fleischer model demonstrated a statistically significant dependent correlation between PFS and OS. The findings were externally validated in an independent cohort.CONCLUSIONSPFS at 6 and 9 months predicted OS in this analysis of patients with metastatic UC treated with first‐line cisplatin‐based chemotherapy and could potentially serve as endpoints in (randomized) phase 2 trials to screen the activity of novel regimens. Cancer 2013;119:3020—3026. © 2013 American Cancer Society.
Differential expression and prognostic value of ERCC1 and thymidylate synthase in resected gastric adenocarcinoma
Authors: Squires Malcolm H. , Fisher Sarah B. , Fisher Kevin E. , Patel Sameer H. , Kooby David A. , El‐Rayes Bassel F. , Staley Charles A. , Farris Alton B. , Maithel Shishir K. 
Published: May 2013

BACKGROUNDExcision repair cross‐complementing gene‐1 (ERCC1) and thymidylate synthase (TS) are key regulatory enzymes whose expression patterns are associated with overall survival (OS) in several malignancies. Their expression patterns and prognostic value in resected gastric adenocarcinoma (GAC) are not known.METHODSIn total, 109 patients who underwent resection for GAC between January 2000 and June 2011 had tissue available for analysis. The primary objective was to assess for the differential expression of ERCC1 and TS using immunohistochemistry. The secondary objective was to assess for the association between OS and the expression of ERCC1 and TS.RESULTSThe median follow‐up was 21.2 months, and the median OS was 28.8 months. Resected GAC exhibited differential expression of ERCC1 (high expression, 23%; n = 25) and TS (high expression, 43%; n = 47). ERCC1 and TS expression were not associated with OS. In a subset analysis of patients who received chemotherapy (n = 73), high ERCC1 expression was associated with decreased OS (16.7 months vs 53.8 months; P = 0.03). After controlling for known adverse pathologic features, high ERCC1 expression persisted as a negative prognostic factor in multivariate Cox regression analysis (hazard ratio, 2.5; 95% confidence interval, 1.03‐6.0; P = .04). Conversely, in patients who underwent resection only (n = 35), high ERCC1 expression demonstrated a trend toward improved OS (40.4 months vs 12.7 months; P = .10); a positive prognostic influence also was present on multivariate analysis (hazard ratio, 0.20; 95% confidence interval, 0.04‐0.86; P = .03).CONCLUSIONSResected GAC exhibited differential expression of TS and ERCC1. Among all patients, ERCC1 and TS expression levels were not associated with OS. High ERCC1 tumor expression was associated with decreased OS in the patients who received chemotherapy but was associated with increased OS in those who underwent surgery alone. ERCC1 expression had prognostic value in resected gastric cancer, and further investigation is warranted. Cancer 2013;119:3242–3250. © 2013 American Cancer Society.
Mindfulness‐based Narrative Therapy for Depression in Cancer Patients
Authors: Rodríguez Vega B. , Bayón Pérez C. , PalaoTarrero A. , Fernández Liria A. 
Published: May 2013

Mindfulness‐based narrative therapy (MBNT) is a therapeutic intervention for the treatment of depression in cancer patients. In a previous randomized controlled trial, MBNT was found to ameliorate anxiety and depression, improve functional dimensions of quality of life, and enhance treatment adherence. In this review, we describe MBNT and its technical characteristics in the context of other psychotherapeutic interventions for depression in cancer patients. We highlight needed adjustments to other narrative approaches and recommend clinical modifications tailored to the needs of cancer patients that are intended to encompass the client's initial depressive narrative. The narrative construction is supported by emotional regulation and attachment relationships on the one hand and by individual and social linguistic capabilities on the other. Through destabilization of the depressive narrative, MBNT facilitates the emergence of new meanings using both verbal and non‐verbal techniques based on mindfulness. The attitude and practice of mindfulness are integrated throughout the therapeutic process. In summary, MBNT makes use of linguistic interventions, promotes mindfulness and emotional regulation, and can be adapted specifically for use with cancer patients. Copyright © 2013 John Wiley & Sons, Ltd.Key Practitioner MessageIn this review, we describe mindfulness‐based narrative therapy (MBNT) for the treatment of depression in cancer patients.In a previous controlled trial, we found significant benefits of MBNT in terms of reducing depressive symptoms and improving treatment adherence and quality of life in depressed, non‐metastatic cancer patients.Narrative construction is socially and neurobiologically derived.MBNT makes use of linguistic interventions, promotes mindfulness and emotional regulation, and can be adapted specifically for use with cancer patients.MBNT is proposed as an interesting and promising intervention, particularly for patients with somatic pathologies.
High efficiency wireless optical links in high transmission speed wireless optical communication networks
Authors: Rashed Ahmed Nabih Zaki 
Published: May 2013

SUMMARYPower link budgets are prepared for wireless optical communication systems to illustrate the optical losses that happen during transmission. This paper has presented optical wireless links, which offer ultra multi gigabit per second data rates and low system complexity. For ground space and/or terrestrial communication systems, these links suffer from atmospheric loss mainly due to fog, and scintillation. Optical wireless links provide high bandwidth solution to the last mile access bottleneck. However, an appreciable availability of the link is always a concern. Wireless optical links are highly weather dependent, and fog is the major attenuating factor reducing the link availability. Link margin, received signal power, transmission bit rate, bit rate distance product, signal‐to‐noise ratio, and BER are the major interesting design parameters in the current study. Copyright © 2013 John Wiley & Sons, Ltd.
An energy‐efficient anti‐jam cognitive system for wireless OFDM communication
Authors: Javed I. , Loan A. , Mahmood W. 
Published: May 2013

SUMMARYIn this paper, anti‐jamming capabilities are proposed for a generic OFDM‐based wireless communication system. The performance of a wireless system may severely degrade in presence of jamming or intentional interferences. A malicious entity can send strong interference or noisy signals in the same transmit frequency band thus preventing the intended receiver to correctly decode the transmitted data. As a countermeasure, our work proposes algorithms and techniques to restore the system performance in presence of such malicious entities. Proposed anti‐jamming system consists of an adaptive framework that adapts itself to varying jammer behavior and wireless environment, and then, it chooses an optimal strategy to effectively cancel out the effect of jamming and channel fading. Optimization problem is formulated as a multi‐objective criterion for maximization of system throughput and minimization of energy consumption. Simulation results computed in Rayleigh fading channels with different wideband jamming modes and powers show that the proposed system effectively cancels out the jamming and channel fading effects thus maximizing the system performance and minimizing cost of energy consumption. Copyright © 2013 John Wiley & Sons, Ltd.
Unified performance analysis of maximal‐ratio combining for spectrum sharing systems with antenna correlation
Authors: Huang Yuzhen , Wu Qihui , Wang Jinlong , Cheng Yunpeng , Zhang Yuming 
Published: May 2013

SUMMARYA comprehensive analytical framework of a spectrum sharing system, in which secondary receiver (SR) is equipped with multiple antennas, is presented over Rayleigh fading channels. The impact of spatial fading correlation on the performance of spectrum sharing system with maximal‐ratio combining at the SR is investigated. In particular, we explicitly derive the CDF and moment generating function of the end‐to‐end signal‐to‐noise ratio by assuming a correlation model with arbitrary eigenvalue multiplicities at the SR. On the basis of these results, we conduct an evaluation of secondary system performance in terms of the outage probability, the average symbol error probability, and the ergodic capacity. All analytical results are verified by Monte Carlo simulations. Furthermore, to obtain an insight of system performance, the asymptotic analysis is studied to obtain the diversity gain and the coding gain in the peak transmit power dominated region. Our results show that the diversity gain is unaffected by antenna correlation whereas the coding gain is degraded. Copyright © 2013 John Wiley & Sons, Ltd.
An efficient t‐out‐of‐n oblivious transfer for information security and privacy protection
Authors: Lou Der‐Chyuan , Huang Hui‐Feng 
Published: May 2013

SUMMARYIn t‐out‐of‐n oblivious transfer (OT), the receiver can only receive t messages out of n messages sent by the sender, and the sender has no idea about which ones have been received. Majority of the existence of previous efficient OT schemes require t calls of 1‐out‐of‐n OT to construct the t‐out‐of‐n OT. Its computational requirements and bandwidth consumption are quite demanding. On the basis of the elliptic curves cryptography, we propose a new t‐out‐of‐n OT protocol for private information retrieval in this article. It is more suitable for the smart cards or mobile units. Copyright © 2013 John Wiley & Sons, Ltd.
Optimal power‐aware relay placement for cooperative wireless sensor networks
Authors: Abdizadeh Mohammad , Jamali‐Rad Hadi , Abolhassani Bahman 
Published: May 2013

SUMMARYWe study the problem of optimizing the symbol error probability (SEP) performance of cluster‐based cooperative wireless sensor networks. Recent studies in literature show that an efficient relay selection protocol based on simple geographical information of the nodes to execute cooperative diversity can significantly improve the SEP performance at the destination of such networks. As well, similar line of research on optimal power allocation (for the source and relay nodes) can be found in literature. However, to achieve the best SEP performance at the destination of a cooperative wireless sensor network, joint optimization of power allocation and relay placement should be accomplished. To this aim, we reformulate the SEP of a multi‐hop cooperative communication in a general form and optimize transmitted power level and relay placement simultaneously. This analysis is developed for both amplify‐and‐forward and decode‐and‐forward relaying protocols. Simulation results demonstrate that the proposed joint optimization can effectively improve the SEP performance of the network. Copyright © 2013 John Wiley & Sons, Ltd.
Thymus‐resident memory CD8+T cells mediate local immunity
Authors: Hofmann Maike , Oschowitzer Anna , Kurzhals Stefan R. , Krüger Caroline C. , Pircher Hanspeter 
Published: May 2013

The thymus is a primary lymphoid organ responsible for production and selection of T cells. Nonetheless, mature T cells and in particular activated T cells can reenter the thymus. Here, we identified memory CD8+ T cells specific for lymphocytic choriomeningitis virus or vaccinia virus in the thymus of mice long‐time after the infection. CD8+ T cells were mainly located in the thymic medulla, but also in the cortical areas. Interestingly, virus‐specific memory CD8+ T cells in the thymus expressed the cell surface markers CD69 and CD103 that are characteristic of tissue‐resident memory T cells in a time‐dependent manner. Kinetic analyses and selective depletion of peripheral CD8+ T cells by antibodies further revealed that thymic virus‐specific memory CD8+ T cells did not belong to the circulating pool of lymphocytes. Finally, we demonstrate that these thymus‐resident virus‐specific memory CD8+ T cells efficiently mounted a secondary proliferative response, exhibited immediate effector functions and were able to protect the thymus from lymphocytic choriomeningitis virus reinfection. In conclusion, the present study not only describes for the first time virus‐specific memory CD8+ T cells with characteristics of tissue‐resident memory T (TRM) cells in a primary lymphoid organ but also extends our knowledge about local T‐cell immunity in the thymus.
Unprecedented Formation of cis‐ and trans‐Di[(3‐chloropropyl)isopropoxysilyl]‐Bridged Double‐Decker Octaphenylsilsesquioxanes
Authors: Ervithayasuporn Vuthichai , Sodkhomkhum Rapheepraew , Teerawatananond Thapong , Phurat Chuttree , Phinyocheep Pranee , Somsook Ekasith , Osotchan Tanakorn 
Published: May 2013

AbstractSilsesquioxane formation competing with the deprotonation of alcohol solvents in the presence of a strong base to form alkoxides is reported for the first time. Evidently, sodium isopropoxide is formed during the synthesis of the sodium salt of a double‐decker octaphenylsilsesquioxane tetrasilanolate in 2‐propanol as the solvent, which leads to the formation of unexpected cis‐ and trans‐di[(3‐chloropropyl)isopropoxysilyl]‐bridged double‐decker octaphenylsilsesquioxanes after in situ coupling with 3‐chloropropyltrichlorosilane. The desired products were characterized by 1H NMR, 13C NMR, and 29Si NMR spectroscopy; ESI‐MS; and single‐crystal X‐ray diffraction.
When the powerful feels wronged: The legitimization effects of advantaged group members' sense of being accused for harboring racial or ethnic biases
Authors: Saguy Tamar , Chernyak‐Hai Lily , Andrighetto Luca , Bryson Jeff 
Published: May 2013

AbstractIn this research, we investigated the psychological sense of feeling wronged as an advantaged group member. By feeling wronged, we refer to advantaged group members who experience themselves being unfairly accused for harboring racial or ethnic biases. Drawing on research on moral threat to the ingroup, we predicted that feeling wronged would lead advantaged group members to legitimize the social hierarchy they are benefiting from, which in turn can undermine their intentions to redress group‐based inequality. Study 1 demonstrated that to the extent advantaged group members (both in Italy and the USA) felt wronged predicted their perceptions of group‐based disparities as more legitimate, which in turn weakened their intentions to act for promoting social change. Study 2 replicated the effect using an experimental manipulation of unfair blame among a sample of Israeli‐Jews. Results are discussed in light of relevant work on competitive victimhood and inverted relative deprivation. Copyright © 2013 John Wiley & Sons, Ltd.