bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience with tafamidis in peritoneal dialysis for a patient diagnosed with transthyretin cardiac amyloidosis
Authors: Fazlic Diego López , García Samuel Abrante , Gerard Micaela , Izquierdo Edduin Martín , Bethencourt Alejandro Alonso , Vannini Luca , García Celestino Hernández , Heras Manuel Macía 
Published: July 2024

ABSTRACT
Cardiac amyloidosis is a cardiomyopathy resulting from the extracellular deposition of proteins such as transthyretin (TTR). We present the case of a 72-year-old male with hereditary cardiac amyloidosis. After confirming the diagnosis, tafamidis, a TTR stabilizer, was administered. Remarkably, tafamidis, when coupled with peritoneal dialysis for chronic kidney disease, maintained stability in both cardiac and renal functions. Previous studies have demonstrated the efficacy of tafamidis in reducing all-cause mortality and cardiovascular hospitalizations, although its use in severe renal failure lacks specific evaluation. This case suggests a potential application of tafamidis in moderate–severe kidney disease, emphasizing the need for further research in this population.
Practical and secure policy-based chameleon hash for redactable blockchains
Authors: Li Nan , Li Yingjiu , Manulis Mark , Tian Yangguang , Yang Guomin 
Published: July 2024

Abstract
Policy-based chameleon hash functions have been widely proposed for its use in blockchain rewriting systems. They allow anyone to create a mutable transaction associated with an access policy, while an authorized user who possesses sufficient rewriting privileges from a trusted authority satisfying the access policy can rewrite the mutable transaction. However, existing chameleon hash functions lack certain fundamental security guarantees, including forward security and backward security. In this paper, we introduce a new primitive called forward/backward-secure policy-based chameleon hash (FB-PCH for short). We present a practical instantiation. We prove that the proposed scheme achieves forward/backward-secure collision-resistance, and show its practicality through implementation and evaluation analysis.
‘There was a bit of PTSD every time I walked through the office door’: Ransomware harms and the factors that influence the victim organization’s experience
Authors: Mott Gareth , Turner Sarah , Nurse Jason R C , Pattnaik Nandita , MacColl Jamie , Huesch Pia , Sullivan James 
Published: July 2024

Abstract
Ransomware is a pernicious contemporary cyber threat for organizations, with ransomware operators intentionally leveraging a range of harms against their victims in order to solicit increasingly significant ransom payments. This article advances current research by engaging in a topical analysis into the depth and breadth of harms experienced by victim organizations and their members of staff. We, therefore, enhance the understanding of the negative experiences from ransomware attacks, particularly looking beyond the financial impact which dominates current narratives. Having conducted an interview or workshop with 83 professionals including ransomware victims, incident responders, ransom negotiators, law enforcement, and government, we identify a wide array of severe harms. For organizations, the risk of business interruption and/or data exposure presents potentially highly impactful financial and reputational harm(s). The victim organization’s staff can also experience a range of under-reported harms, which include physiological and physical harms that may be acute. We also identify factors that can either alleviate or aggravate the experiencing of harms at the organizational and employee level; including ransomware preparedness, leadership culture, and crisis communication. Given the scale and scope of the identified harms, the paper provides significant new empirical evidence to emphasize ransomware’s positioning as a whole-of-organization crisis phenomenon, as opposed to an ‘IT problem’. We argue that the wider discourse surrounding ransomware harms and impacts should be reflective of the nature of the real-term experience(s) of victims. This, in turn, could help guide efforts to alleviate ransomware harms, through improved organizational ransomware preparedness and tailored post-ransomware mitigation.
Misconception of ‘malignant’ and ‘scissor-like compression’ of interarterial course in anomalous aortic origin of a coronary artery: a case series
Authors: Schütze Jonathan , Stark Anselm W , Bigler Marius R , Räber Lorenz , Gräni Christoph 
Published: July 2024

Abstract

Background
The notion that the ‘interarterial’ segment of anomalous aortic origin of a coronary artery (AAOCA) is ‘malignant’ and ‘scissor-like’ compressed between the aorta and pulmonary artery (PA) is debated, owing to the lower pressure in the pulmonary system compared with that in the coronary system. However, data supporting or refuting this belief under stress conditions are lacking.

Case summary
Three cases of right AAOCA with interarterial/intramural courses (52, 66, and 51 years old) were assessed. Invasively measured fractional flow reserve (FFR) under dobutamine was 0.85, 0.82, and 0.81, respectively. Intravascular ultrasound illustrated lateral vessel compression of the intramural course with a decrease of minimal lumen area (MLA) (i.e. 5.71–3.47 mm2, 5.88–4.00 mm2, and 5.85–4.06 mm2) under stress conditions with heart rates of 130, 140, and 150 b.p.m., respectively. Pulmonary artery pressure (PAP) increased from rest {s/d (m) [systolic/diastolic (mean)] 22/11 (15), 15/2 (5), and 24/6 (14) mmHg} to stress [s/d (m) 47/24 (36), 30/3 (11), and 36/22 (24) mmHg] and remained below aortic peak pressure (blood pressure, BP) rest [s/d (m) 116/64 (91), 94/48 (71), 99/53 and (62) mmHg]; BP stress [s/d (m) 142/63 (80), 123/63 (88), and 86/46 (62) mmHg]; coronary pressure (CoP) rest [s/d (m) 100/59 (80), 80/45 (62), and 83/47 (63) mmHg]; and CoP stress [s/d (m) 95/60 (69),101/54 (72), and 70/32 (50) mmHg].

Conclusion
This case series challenges the assumption that the interarterial segment of AAOCA is scissor-like compressed by both the aorta and PA. The decrease in MLA and FFR under stress is due to the aorta’s unidirectional lateral compression on the intramural segment. Additionally, the term ‘malignant’ should not be universally applied to all AAOCA cases with an interarterial course, as not all result in haemodynamic significance.
The effect of post-traumatic chondropathy on the functional state of knee joints in athletes while playing basketball
Authors: Cui Wenpeng , Bezmilov Mykola 
Published: July 2024

Abstract
The widespread occurrence of knee injuries in athletes when playing basketball, in particular, damage to the cartilage system of the knee joint is reviewed. Basketball players may develop post-traumatic chondropathy with a subsequent change in the functional state of knee joints, which is inextricably linked with a decrease in the quality of life, the occurrence of pain syndrome, shortening of career duration, an increased risk of surgical interventions, and possible disability, from a long-term perspective. This review was conducted to explore modern ideas about the impact of post-traumatic chondropathy on the functional state of knee joints in athletes during basketball games. Literature databases were searched for relevant studies. Given the character of the basketball game, knee injuries, both acute and chronic, are widespread among athletes of this sport, including cartilaginous defects of the knee joint. The findings of this study are of practical value for sports medicine doctors, physiotherapists, and traumatologists because they present the main mechanisms of knee injuries in athletes when playing basketball and the possible consequences of these injuries in the long term.
NaV1.5 autoantibodies in Brugada syndrome: pathogenetic implications
Authors: Tarantino Adriana , Ciconte Giuseppe , Melgari Dario , Frosio Anthony , Ghiroldi Andrea , Piccoli Marco , Villa Marco , Creo Pasquale , Calamaio Serena , Castoldi Valerio , Coviello Simona , Micaglio Emanuele , Cirillo Federica , Locati Emanuela Teresina , Negro Gabriele , Boccellino Antonio , Mastrocinque Flavio , Ćalović Žarko , Ricagno Stefano , Leocani Letizia , Vicedomini Gabriele , Santinelli Vincenzo , Rivolta Ilaria , Anastasia Luigi , Pappone Carlo 
Published: July 2024

Abstract

Background and Aims
Patients suffering from Brugada syndrome (BrS) are predisposed to life-threatening cardiac arrhythmias. Diagnosis is challenging due to the elusive electrocardiographic (ECG) signature that often requires unconventional ECG lead placement and drug challenges to be detected. Although NaV1.5 sodium channel dysfunction is a recognized pathophysiological mechanism in BrS, only 25% of patients have detectable SCN5A variants. Given the emerging role of autoimmunity in cardiac ion channel function, this study explores the presence and potential impact of anti-NaV1.5 autoantibodies in BrS patients.

Methods
Using engineered HEK293A cells expressing recombinant NaV1.5 protein, plasma from 50 BrS patients and 50 controls was screened for anti-NaV1.5 autoantibodies via western blot, with specificity confirmed by immunoprecipitation and immunofluorescence. The impact of these autoantibodies on sodium current density and their pathophysiological effects were assessed in cellular models and through plasma injection in wild-type mice.

Results
Anti-NaV1.5 autoantibodies were detected in 90% of BrS patients vs. 6% of controls, yielding a diagnostic area under the curve of .92, with 94% specificity and 90% sensitivity. These findings were consistent across varying patient demographics and independent of SCN5A mutation status. Electrophysiological studies demonstrated a significant reduction specifically in sodium current density. Notably, mice injected with BrS plasma showed Brugada-like ECG abnormalities, supporting the pathogenic role of these autoantibodies.

Conclusions
The study demonstrates the presence of anti-NaV1.5 autoantibodies in the majority of BrS patients, suggesting an immunopathogenic component of the syndrome beyond genetic predispositions. These autoantibodies, which could serve as additional diagnostic markers, also prompt reconsideration of the underlying mechanisms of BrS, as evidenced by their role in inducing the ECG signature of the syndrome in wild-type mice. These findings encourage a more comprehensive diagnostic approach and point to new avenues for therapeutic research.
The Erasmus+ EUMOVE project—a school-based promotion of healthy lifestyles to prevent obesity in European children and adolescents
Authors: Ruiz-Hermosa Abel , Sánchez-López Mairena , Castro-Piñero José , Grao-Cruces Alberto , Camiletti-Moirón Daniel , Martins João , Mota Jorge , Ceciliani Andrea , Murphy Marie , Vuillemin Anne , Sánchez-Oliva David ,   EUMOVE Consortium, Calvo Tomás García , Ponce Inmaculada González , González Juan José Pulido , Marcos Francisco Miguel Leo , Miguel Pedro Antonio Sánchez , Marín Diego Muñoz , Serrano Javier Sevil , Serrano Miguel Ángel Tapia , Gómez Rocío Izquierdo , Caveda Julio Conde , Moledo Carmen Padilla , Martínez-Vizcaíno Vicente , Morcillo Carlos González , Garzón Palma Chillón , Onofre Marcos , Marques Adilson , Ribeiro Tiago , Silva Paula , Santos Paula , Pizarro Andreia , Corrion Karine , Garbarino Jean-Marie , Dallolio Laura , Masini Alice , Marini Sofia , Carlin Angela , Connolly Sinead , Ferro Nuno , Bolaños Felix , Costa João , Pjevac Dusan , Fournier Marion , Mulato Raffaela , Riegger Stephan 
Published: July 2024

Abstract
The aim of this study was to describe the goals, activities, and methods of EUMOVE project in developing a set of resources targeting both primary and secondary schools that allow the entire educational community to promote healthy lifestyles (HL). The EUMOVE project is an Erasmus+ program based in the Creating Active Schools (CAS) framework. The project lasted 3 years and was developed by 14 academic and non-governmental institutions from Spain, Portugal, France, Italy, and the UK. EUMOVE was divided into three phases. In the first phase, several work packages were carried out aimed to ensure the coordination/management of the project activities. In the second phase, seven educational resources strengthened by rigorous scientific research were developed to promote HL from schools. During the last phase, all the resources were disseminated through scientific seminars, workshops with families and teachers, and the online promotion by the non-governmental institutions of each country. The EUMOVE project developed and promoted a smartphone APP, video/activity repository of physically active lessons, active break virtual platform, learning units, and parent/teachers/school-leaders’ guidelines to promote physical activity, active commuting, active school playgrounds, healthy diet, and sleep habits. To our knowledge, EUMOVE is the first European project to provide a set of practical tools based on scientific evidence to help schools or future school-wide interventions implement a paradigm shift based on the CAS framework for the promotion of HL. Future research will need to investigate the implementation, effectiveness, and scalability of this proposal.
Development and validation of the Environmental Health Literacy Index: a new tool to assess the environmental health literacy among university students
Authors: Fiore Maria , Lorini Chiara , Bonaccorsi Guglielmo , Paoli Sonia , Vaccaro Gabriele , Verani Marco , Federigi Ileana , Ferrante Margherita , Carducci Annalaura 
Published: July 2024

Abstract
Environmental health literacy (EHL) is a rather recent concept that applies health literacy skills to environmental issues. Research in this field is still at the beginning, and there is currently no existing tool in the literature designed to comprehensively assess individual general EHL among university students. The aim of our study is to fill this gap through the validation of the Environmental Health Literacy Index (EHLI) in such a target group. We adapted a previously administered survey, originally completed by 4778 university students from various Italian universities. Starting from the original questionnaire, our methodology involved a three-round item selection process, followed by a comprehensive evaluation of the instrument’s psychometric properties. The EHLI consists of 13 Likert-type items, covering three primary domains of health literacy: functional (six items), interactive (three items), and critical (four items). The Cronbach’s alpha coefficient is 0.808 for the global scale, while it stands at 0.888 for the functional, 0.795 for the critical, and 0.471 for the interactive components. The area under the receiver operating characteristic curve reached a value of 0.643. Spearman correlation analysis revealed a significant yet slight correlation between EHLI and both functional health literacy score and the extent of pro-environmental behaviors adoption. Our study serves as an important initial step in developing a tool able to evaluate the EHL of university-aged individuals. Further research efforts may improve the questionnaire’s validity and completeness, as well as to explore its applicability to different age groups.
ETV4/NSUN2 Axis modulates aerobic glycolysis and malignancy in HSCC
Authors: Ding Xiaoxu , Zhang Xueyan , Fang Panxia , Bai Weiliang 
Published: July 2024

Abstract
This study delves into the molecular intricacies of hypopharyngeal squamous cell carcinoma (HSCC), specifically focusing on the pivotal role played by ETS translocation variant 4 (ETV4) in aerobic glycolysis. The objective is to uncover new targets for early diagnosis and treatment of HSCC. ETV4 expression in HSCC tissues was rigorously examined, revealing its association with patient survival. Through comprehensive experimentation, we demonstrated that ETV4 activation promotes HSCC cell proliferation and invasion while inhibiting apoptosis. Furthermore, in vivo experiments confirmed the tumor-promoting effect of ETV4 activation. The study elucidated the binding of ETV4 to the NSUN2 promoter and its influence on PKM2 expression, thereby regulating glycolysis and cellular functions in HSCC.
Transcription factors LvBBX24 and LvbZIP44 coordinated anthocyanin accumulation in response to light in lily petals
Authors: Gao Zhenhua , Sun Yibo , Zhu Ziman , Ni Na , Sun Shaokun , Nie Mengyao , Du Weifeng , Irfan Muhammad , Chen Lijing , Zhang Li 
Published: July 2024

Abstract
Lily (Lilium spp.), a horticultural crop serving both ornamental and edible functions, derives its coloration primarily from anthocyanins. However, limited studies have been conducted on the accumulation of anthocyanins within lilies. In this study, we cloned a light-induced transcription factor named as LvBBX24 in lilies. Through genetic and biochemical analysis, we determined that LvBBX24 could upregulate the transcription of LvMYB5 and facilitate anthocyanin synthesis. Moreover, we identified that darkness promoted the degradation of LvBBX24 protein. Through screening a yeast library, we identified LvbZIP44 acts as its interacting partner. Genetic testing confirmed that LvbZIP44 also plays a role in promoting lily anthocyanin synthesis. This indicates a potential synergistic regulatory effect between LvBBX24 and LvbZIP44. Our study indicates that LvBBX24 and LvbZIP44 cooperate to regulate anthocyanin accumulation in lily petals. These findings provide compelling evidence supporting the idea that LvBBX24 and LvbZIP44 may form a looped helix surrounding the LvMYB5 promoter region to regulate anthocyanin biosynthesis.
The ECHR and the Positive Obligation to Criminalise Domestic Psychological Violence
Authors: Hedlund Niels 
Published: July 2024

Abstract
This article explores the scope of the positive obligation deriving from the case law of the European Court of Human Rights (ECtHR) to criminalise forms of domestic psychological violence. This is primarily done by examining the implications of Volodina v Russia (No. 1), Volodina v Russia (No. 2) and Tunikova and Others v Russia regarding the obligation in question. Additionally, this article addresses different legislative approaches towards the criminalisation of domestic violence that have been distinguished by the ECtHR and discusses whether they adequately criminalise domestic psychological violence. Some approaches appear ill-suited as they concern national offences that focus on serious incidents. Domestic psychological violence, on the other hand, can involve a course of conduct consisting of seemingly minor incidents. It is concluded that State Parties should review to what extent such forms of psychological violence are criminalised under their national criminal laws.
A multicentre study of amphotericin B treatment for histoplasmosis: assessing mortality rates and adverse events
Authors: Sekiguchi William Kazunori , de Oliveira Vítor Falcão , Cavassin Francelise Bridi , Taborda Mariane , Gonçalves Kono Magri Adriana Satie , da Cruz Isabela Carvalho Leme Vieira , Vidal Jose Ernesto , Falci Diego Rodrigues , Silva de Miranda Godoy Cássia , de Bastos Ascenço Soares Renata , de Oliveira Carla Sakuma , Mendes Ana Verena Almeida , Breda Giovanni Luís , Rego Caroline Martins , Félix Maíra Araujo , Katopodis Paula Pacheco , da Silva do Ó Julia Raquel , Abrão Mirela Pereira Lima , Baú-Carneiro João Luiz , Pereira Talita Teles Teixeira , Queiroz-Telles Flávio , Mihailenko Chaves Magri Marcello 
Published: July 2024

Abstract

Background
Progressive disseminated histoplasmosis is a significant issue in Latin America, particularly in Brazil, contributing to high mortality rates.

Objectives
Our objectives were to comprehensively describe histoplasmosis treatment with various amphotericin B (AmB) formulations, including mortality rates, adverse effects and risk factors for mortality.

Methods
This multicentre retrospective cohort study (January 2014–December 2019) evaluated medical records of patients with proven or probable histoplasmosis treated with at least two doses of AmB in seven tertiary medical centres in Brazil. We assessed risk factors associated with death during hospitalization using univariate and multivariate analyses.

Results
The study included 215 patients, mostly male (n = 158, 73%) with HIV infection (n = 187, 87%), and a median age of 40 years. Only 11 (5%) patients initiated treatment with liposomal amphotericin B (L-AmB). Amphotericin B deoxycholate (D-AmB) was administered to 159 (74%) patients without changes in the treatment. The overall mortality during hospitalization was 23% (50/215). Variables independently associated with mortality were use of D-AmB (OR 4.93) and hospitalization in ICU (OR 9.46). There was a high incidence of anaemia (n = 19, 90%), acute kidney injury (n = 96, 59%), hypokalaemia (n = 73, 55%) and infusion reactions (n = 44, 20%) during treatment.

Conclusions
We found that D-AmB was the main formulation, which was also associated with a higher mortality rate. Lipid formulations of AmB have become more readily available in the public health system in Brazil. Further studies to evaluate the effectiveness of L-AmB will likely show improvements in the treatment outcomes for patients with disseminated histoplasmosis.
Returning value from the All of Us Research Program to PhD-level nursing students using ChatGPT as programming support: results from a mixed-methods experimental feasibility study
Authors: Reading Turchioe Meghan , Kisselev Sergey , Fan Ruilin , Bakken Suzanne 
Published: July 2024

Abstract

Objective
We aimed to evaluate the feasibility of using ChatGPT as programming support for nursing PhD students conducting analyses using the All of Us Researcher Workbench.

Materials and Methods
9 students in a PhD-level nursing course were prospectively randomized into 2 groups who used ChatGPT for programming support on alternating assignments in the workbench. Students reported completion time, confidence, and qualitative reflections on barriers, resources used, and the learning process.

Results
The median completion time was shorter for novices and certain assignments using ChatGPT. In qualitative reflections, students reported ChatGPT helped generate and troubleshoot code and facilitated learning but was occasionally inaccurate.

Discussion
ChatGPT provided cognitive scaffolding that enabled students to move toward complex programming tasks using the All of Us Researcher Workbench but should be used in combination with other resources.

Conclusion
Our findings support the feasibility of using ChatGPT to help PhD nursing students use the All of Us Researcher Workbench to pursue novel research directions.