bluuebunny/crossref_metadata_2025_split huggingface dataset:
US-based, Prospective, Blinded Study of Thyrotropin Receptor Antibody in Autoimmune Thyroid Disease
Authors: Lupo Mark A , Olivo Paul D , Luffy Maximilian , Wolf Jan , Kahaly George J 
Published: July 2024

Abstract

Context
Bioassays provide information on the functionality of thyrotropin receptor antibodies (TSH-R-Ab) and thus may offer more clinical utility than binding assays.

Objective
In this prospective, blinded, US-based study, the clinical performance of several TSH-R-Ab assays was compared.

Setting
US endocrinology clinic.

Subjects
One hundred sixty-two unselected, consecutive, well-documented patients with various thyroid diseases and healthy controls.

Intervention(s)
Blinded TSH-R-Ab measurements.

Main Outcome Measure(s)
Sensitivity and specificity of 4 TSH-R-Ab assays.

Results
The 4 TSH-R-Ab assays were negative in all 42 patients without autoimmune thyroid disease (AITD). In 104 patients with Graves’ disease (GD), irrespective of the disease duration, TSH-R-Ab positivity was present in 65 (63%), 67 (65%), and 87 (84%) for the Cobas and Immulite binding assays and stimulatory TSH-R-Ab [thyroid-stimulating immunoglobin (TSI)] bioassay, respectively (TSI vs Immulite P &lt; .0025, TSI vs Cobas P &lt; .0009). Fifteen newly diagnosed GD patients were all positive in the TSI bioassay, but only 11 (73%) were positive in the Cobas and Immulite binding assays. Nine GD patients with biochemical subclinical hyperthyroidism were TSI-positive but Immulite- and Cobas-negative. Two GD patients were blocking TSH-R-Ab [thyroid-blocking immunoglobin (TBI)]-positive and TSI-negative, and the Immulite and Cobas were positive in both. Additional serum samples from AITD patients that consisted of 30 TBI-positive and 10 TSI-positive samples were blindly tested in the binding assays. Only 6 of the 10 TSI-positive samples were positive in both binding assays, and 30 and 28 of the TBI-positive samples were positive in the Cobas and Immulite assays, respectively.

Conclusion
Binding TSH-R-Ab assays are less sensitive than TSI bioassays and are not specific for stimulating antibodies. Measuring the function of TSH-R-Ab in a bioassay can provide useful information to clinicians.
Tutuola in the Bush of Primitivism
Authors: Paris Václav 
Published: July 2024

Abstract
This article situates the early novels of Amos Tutuola—The Palm-Wine Drinkard (1952) and My Life in the Bush of Ghosts (1954)—in relation to literary primitivism. The first part outlines the initial misconstrual of Tutuola in the United Kingdom and United States as a “true primitive,” capable of producing authentically what earlier modernist primitivists attempted to produce by simulation. The article then argues that Tutuola anticipated the reception of his texts and himself as primitive, and it describes how he manipulated a binary division in Yoruba folktales between the realm of the village and the realm of the bush. The third part of the article rehistoricizes Tutuola’s early works on this basis, showing how his primitivism relates both to the work of Chinua Achebe and Wole Soyinka, as well as to global thinking about spaces of primitivity in the 1950s in midcentury modernism and Cold War discourses of apocalypse. In this way, the article claims the importance of The Palm-Wine Drinkard and My Life in the Bush of Ghosts both to African modernism and to the evolving engagement across the twentieth century between eccentric writing and the preservation of an imagined remnant at the edge of the world-system.
Transgenesis enables mapping of segmental ganglia in the leech Helobdella austinensis
Authors: Kuo Dian-Han , Szczupak Lidia , Weisblat David A. , Portiansky Enrique L. , Winchell Christopher J. , Lee Jun-Ru , Tsai Fu-Yu 
Published: July 2024

ABSTRACT
The analysis of how neural circuits function in individuals and change during evolution is simplified by the existence of neurons identified as homologous within and across species. Invertebrates, including leeches, have been used for these purposes in part because their nervous systems comprise a high proportion of identified neurons, but technical limitations make it challenging to assess the full extent to which assumptions of stereotypy hold true. Here, we introduce Minos plasmid-mediated transgenesis as a tool for introducing transgenes into the embryos of the leech Helobdella austinensis (Spiralia; Lophotrochozoa; Annelida; Clitellata; Hirudinida; Glossiphoniidae). We identified an enhancer driving pan-neuronal expression of markers, including histone2B:mCherry, which allowed us to enumerate neurons in segmental ganglia. Unexpectedly, we found that the segmental ganglia of adult transgenic H. austinensis contain fewer and more variable numbers of neurons than in previously examined leech species.
O aluno cidadão: da teoria à prática sobre a participação popular no planejamento público
Authors: Lima Martins Faria Tamara 
Published: July 2024

Objetivo: Integrar teoria e prática sobre participação social e planejamento público, dinamizando a aprendizagem dos alunos da graduação em Administração fomentando um pensamento crítico na perspectiva da gestão e da cidadania sobre os problemas públicos.
Escopo: Este relato descreve uma prática de ensino que integra o aprendizado em sala de aula com a participação direta do aluno-cidadão em uma audiência pública e a produção colaborativa de produtos de comunicação científica formal (em evento acadêmico e profissional) e outra em redes sociais para “não-acadêmicos” sobre o papel da sociedade no planejamento público. Na experiência relatada foram realizadas atividades alinhadas à aprendizagem baseada em problemas (APB), aprendizagem experiencial e aprendizagem colaborativa.
Originalidade: o artigo apresenta as possibilidades para aplicar os conceitos de forma pragmática e com relevância social possibilitando o protagonismo e conscientização dos alunos sobre seu papel na sociedade.
Relevância: os problemas públicos pensados a partir da realidade dos alunos são possibilidades de reflexão e um desafio para pensar na solução de problemas de forma colaborativa, integrando as atividades de ensino com as práticas políticas e sociais.
Relationship between anhedonia, biological rhythms, functioning and depression severity in patients with bipolar disorder.
Authors: Gorostowicz Aleksandra , Chrobak Adrian Andrzej , Dudek Dominika , Siwek Marcin 
Published: July 2024

Cel pracyCelem pracy było zbadanie związku pomiędzy anhedonią, zaburzeniami rytmów biologicznych, funkcjonowaniem i nasileniem depresji u pacjentów z chorobą afektywną dwubiegunową (ChAD).MetodaDo badania włączono 58 pacjentów w wieku 18-65 lat z depresją w przebiegu ChAD. Uczestnicy byli oceniani przy użyciu następujących skal: Skala oceny wymiarów anhedonii (DARS), Skala Przyjemności Snaitha-Hamiltona (SHAPS), Krótki inwentarz objawów depresyjnych – samoopisowy (QIDS-SR), Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), Functioning Assessment Short Test (FAST). Obliczono korelacje pomiędzy zmiennymi. Zbudowano modele regresji liniowej z FAST lub QIDS-SR jako zmienną zależną. Przeprowadzono analizę mediacji.WynikiZaobserwowano istotne statystycznie korelacje pomiędzy uwzględnionymi zmiennymi. Rozregulowanie rytmów biologicznych i anhedonia były niezależnymi predyktorami poziomu funkcjonowania lub nasilenia depresji. Analiza mediacji wykazała istotną statystycznie mediację związku pomiędzy anhedonią a nasileniem depresji/funkcjonowaniem przez wynik skali BRIAN.WnioskiPo raz pierwszy wykazaliśmy interakcje pomiędzy anhedonią, rozregulowaniem rytmów biologicznych a nasileniem depresji/funkcjonowaniem u pacjentów z ChAD. Deficyty w układzie nagrody poprzez zakłócanie rytmu codziennych aktywności i kontaktów społecznych mogą skutkować większymi trudnościami w funkcjonowaniu i większym nasileniem objawów depresyjnych.
A High-Dimensional Choice Model for Online Retailing
Authors: Jiang Zhaohui (Zoey) , Li Jun , Zhang Dennis 
Published: July 2024

Online retailers are facing an increasing variety of product choices and diversified consumer decision journeys. To improve many operations decisions for online retailers, such as demand forecasting and inventory management and pricing, an important first step is to obtain an accurate estimate of the substitution patterns among a large number of products offered in the complex online environment. Classic choice models either do not account for these substitution patterns beyond what is reflected through observed product features or do so in a simplified way by making a priori assumptions. These shortcomings become particularly restrictive when the underlying substitution patterns get complex as the number of options increases. We provide a solution by developing a high-dimensional choice model that allows for flexible substitution patterns and easily scales up. We leverage consumer clickstream data and combine econometric and machine learning (graphical lasso, in particular) methods to learn the substitution patterns among a large number of products. We show our method offers more accurate demand forecasts in a wide range of synthetic scenarios when compared with classical models (e.g., the independent and identically distributed Probit model), reducing out-of-sample mean absolute percentage error by 10%–30%. Such performance improvement is further supported by observations from a real-world empirical setting. More importantly, our method excels in precisely recovering substitution patterns across products. Compared with benchmark models, it reduces the percentage deviation from the underlying elasticity matrix by approximately half. This precision serves as a critical input for enhancing business decisions such as assortment planning, inventory management, and pricing strategies. This paper was accepted by Vishal Gaur, operations management. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2020.02715 .
Oncology nurses' lived experience of caring for patients with advanced cancer in healthcare systems without palliative care services
Authors: Abu-Odah Hammoda , Leung Doris , Chan Engle Angela , Bayuo Jonathan , Su Jing Jing , Ho Ka-Yan , Lam Katherine-Ka-Wai , Yuen John Wai-Man , Zhao Ivy Yan , Allsop Matthew J , Al Zoubi Fadi M , Al Khaldi Mohammed N , Krakauer Eric L , Molassiotis Alex 
Published: July 2024

Background: Caring for patients with advanced cancer is complex and challenging, requiring varied expertise, including symptom management, communication skills, care coordination and emotional resilience. Within existing literature, the lived experiences of oncology nurses are poorly articulated in countries with a lower income where formal palliative care (PC) is absent. Aim: To explore the lived experiences of Gazan oncology nurses who provide care to patients with advanced cancer in healthcare systems, without formal palliative care infrastructure. Methods: A phenomenological approach was adopted. Semi-structured interviews were conducted between January and April 2022, in the Turkish Palestinian Friendship Hospital. Thematic analysis used the themes (corporeality, relationality, spatiality and temporality) to facilitate reflection on the meaning of participants' lived experiences. Results: Interviews were undertaken with 16 oncology nurses. The experience of the ‘erosion of nurses’ work when coping with anxious attachments to patients and families’ was the overarching theme in nurses’ views, characterised by five sub-themes: (1) inadequacy of PC training and resources, (2) serving humanity, (3) pride in their profession, (4) existential distress and the coping strategies used by nurses, and (5) reported stress and anxiety when caring for seriously ill patients and their families. Conclusions: The study sheds light on the challenges and powerful emotions experienced by oncology nurses who care for patients with advanced cancer, yet lack the necessary PC training and institutional resources. The findings indicate an urgent need for PC training for nurses within the Gazan healthcare system and other lower-income settings. Assessing nurses’ emotions and relationships with patients and family caregivers is imperative to enable optimum care for patients with cancer and to foster resilience among their nurses.
Stage IV non-small cell lung cancer with multiple metastases to the small intestine leading to intussusception: A case report
Authors: Niu Qi-Guang , Huang Min-Hao , Kong Wei-Qi , Yu Yang 
Published: July 2024

BACKGROUND
Gastrointestinal tract metastasis from lung cancer is rare and compared to small cell lung cancer (SCLC), non-SCLC (NSCLC) is even less likely to metastasize in this manner. Additionally, small intestinal tumors can also present with diverse complications, some of which require urgent intervention.
CASE SUMMARY
In this report, we detail a unique case of stage IV lung cancer, where the presence of small intestine tumors led to intussusception. Subsequent to a small intestine resection, pathology confirmed that all three tumors within the small intestine were metastases from adenocarcinoma of the lung. The postoperative follow-up period extended beyond 14 mo.
CONCLUSION
In patients with stage IV NSCLC, local tumor control can be achieved with various treatments. However, if small intestinal metastasis occurs, surgical intervention remains necessary, as it may improve survival.
Uterine artery pseudoaneurysm caused by hysteroscopic surgery: A case report
Authors: Kakinuma Kaoru , Kakinuma Toshiyuki , Ueyama Kyouhei , Okamoto Rora , Yanagida Kaoru , Takeshima Nobuhiro , Ohwada Michitaka 
Published: July 2024

BACKGROUND
We report a case of uterine artery pseudoaneurysm (UAP) occurrence during hysteroscopic endometrial polypectomy and its treatment via uterine artery embolization (UAE).
CASE SUMMARY
A 48-year-old primigravid, primiparous patient was incidentally found to have an endometrial polyp during a health checkup, and underwent a hysteroscopic polypectomy at another hospital. Her cervix was dilated with a Laminken-R® device. After the Laminken-R® was withdrawn, a large amount of genital bleeding was observed. This bleeding persisted after the hysteroscopic polypectomy, and, as hemostasis became impossible, the patient was transferred to our hospital by ambulance. On arrival, transvaginal ultrasonography revealed a 3-cm hypoechoic mass with a swirling internal pulse on the right side of the uterus, and color Doppler ultrasonography showed feeder vessels penetrating the mass. Pelvic contrast-enhanced computed tomography (CT) confirmed the presence of a mass at this site, and vascular proliferation was observed within the uterine cavity. Consequently, UAP was diagnosed, and UAE was performed. The patient’s postoperative course was uneventful, and 6 mo post-UAE, no recurrence of blood flow to the UAP was observed.
CONCLUSION
When abnormal genital bleeding occurs during hysteroscopic surgery, ultrasonography and contrast-enhanced CT can assist in the detection of early UAPs.
Molecular characterization of the circadian clock in patients with Parkinson’s disease–CLOCK4PD Study protocol
Authors: Yalçin Müge , Peralta Ana Rita , Bentes Carla , Silva Cristiana , Guerreiro Tiago , Ferreira Joaquim J. , Relógio Angela 
Published: July 2024

Introduction
Circadian rhythms (CRs) orchestrate intrinsic 24-hour oscillations which synchronize an organism’s physiology and behaviour with respect to daily cycles. CR disruptions have been linked to Parkinson’s Disease (PD), the second most prevalent neurodegenerative disorder globally, and are associated to several PD-symptoms such as sleep disturbances. Studying molecular changes of CR offers a potential avenue for unravelling novel insights into the PD progression, symptoms, and can be further used for optimization of treatment strategies. Yet, a comprehensive characterization of the alterations at the molecular expression level for core-clock and clock-controlled genes in PD is still missing.

Methods and analysis
The proposed study protocol will be used to characterize expression profiles of circadian genes obtained from saliva samples in PD patients and controls. For this purpose, 20 healthy controls and 70 PD patients will be recruited. Data from clinical assessment, questionnaires, actigraphy tracking and polysomnography will be collected and clinical evaluations will be repeated as a follow-up in one-year time. We plan to carry out sub-group analyses considering several clinical factors (e.g., biological sex, treatment dosages, or fluctuation of symptoms), and to correlate reflected changes in CR of measured genes with distinct PD phenotypes (diffuse malignant and mild/motor-predominant). Additionally, using NanoStringⓇ multiplex technology on a subset of samples, we aim to further explore potential CR alterations in hundreds of genes involved in neuropathology pathways.

Discussion
CLOCK4PD is a mono-centric, non-interventional observational study aiming at the molecular characterization of CR alterations in PD. We further plan to determine physiological modifications in sleep and activity patterns, and clinical factors correlating with the observed CR changes. Our study may provide valuable insights into the intricate interplay between CR and PD with a potential to be used as a predictor of circadian alterations reflecting distinct disease phenotypes, symptoms, and progression outcomes.
Feasibility and safety of ultrasound-guided percutaneous transhepatic measurement of portal venous pressure
Authors: Hu Yanshan , Duan Shaobo , Zhang Ye , Hao Liuwei , Wang Shuaiyang , Xue Fei , Zhang Kewei , Zhu Yadong , Zhang Lianzhong 
Published: July 2024

Background and objective
The measurement of portal venous pressure (PVP) has been extensively studied, primarily through indirect methods. However, the potential of ultrasound-guided percutaneous transhepatic PVP measurement as a direct method has been largely unexplored. This study aimed to investigate the accuracy, safety, and feasibility of this approach.

Methods
In vitro, the experiment aimed to select a needle that could accurately transmit pressure, had a small inner diameter and was suitable for liver puncture, and performed on 20 healthy New Zealand white rabbits. An ultrasound-guided percutaneous transhepatic portal vein puncture was undertaken to measure PVP. Additionally, free hepatic venous pressure (FHVP) and wedged hepatic venous pressure (WHVP) were measured under digital subtraction angiography (DSA). The correlation between the two methods was assessed. Enroll study participants from October 18, 2023 to November 11, 2023 with written informed consent. Five patients were measured the PVP under ultrasound guidance before surgery to determine the feasibility of this measurement method.

Results
There was no significant difference in the results obtained using 9 different types of needles (P > 0.05). This demonstrated a great repeatability (P < 0.05). The 22G chiba needle with small inner diameter, allowing for accurate pressure transmission and suitable for liver puncture, was utilized for percutaneous transhepatic PVP measurement. There were positive correlations between PVP and HVPG (r = 0.881), PVP and WHVP (r = 0.709), HVPG and WHVP (r = 0.729), IVCP and FHVP (r = 0.572). The PVP was accurately and safely measured in 5 patients with segmental hepatectomy. No complications could be identified during postoperative ultrasound.

Conclusion
Percutaneous transhepatic portal venous puncture under ultrasound guidance is accurate, safe and feasible to measure portal venous pressure.

Clinical trial registration number
This study has been registered in the Chinese Clinical Trial Registry with registration number ChiCTR2300076751.
Validating the performance of organ dysfunction scores in children with infection: A cohort study
Authors: Li Shaojun , Tan Tao , Li Jing , Li Hongdong , Zhou Liang , Bai Ke , Xiao Li , Xu Ximing , Tan Liping 
Published: July 2024

Purpose
We aimed to validate the performance of six available scoring models for predicting hospital mortality in children with suspected or confirmed infections.

Methods
This single-center retrospective cohort study included pediatric patients admitted to the PICU for infection. The primary outcome was hospital mortality. The six scores included the age-adapted pSOFA score, SIRS score, PELOD2 score, Sepsis-2 score, qSOFA score, and PMODS.

Results
Of the 5,356 children admitted to the PICU, 9.1% (488) died, and 25.1% (1,342) had basic disease with a mortality rate of 12.7% (171); 65.3% (3,499) of the patients were younger than 2 years, and 59.4% (3,183) were male. The discrimination abilities of the pSOFA and PELOD2 scores were superior to those of the other models. The calibration curves of the pSOFA and PELOD2 scores were consistent between the predictions and observations. Elevated lactate levels were a risk factor for mortality.

Conclusion
The pSOFA and PELOD2 scores had superior predictive performance for mortality. Given the relative unavailability of items and clinical operability, the pSOFA score should be recommended as an optimal tool for acute organ dysfunction in pediatric sepsis patients. Elevated lactate levels are related to a greater risk of death from infection in children in the PICU.
Targeted vibratory therapy as a treatment for proprioceptive dysfunction: Clinical trial in older patients with chronic low back pain
Authors: Sakai Yoshihito , Morita Yoshifumi , Kawai Keitaro , Fukuhara Jo , Ito Tadashi , Yamazaki Kazunori , Watanabe Tsuyoshi , Wakao Norimitsu , Matsui Hiroki 
Published: July 2024

IntroductionProprioceptive function declines with age, leading to falls, pain, and difficulties in performing activities of daily living among older adults. Although individuals with low back pain (LBP) exhibit decreased lumbosacral proprioception in various postures, the mechanism by which reduced proprioceptive function causes LBP remains uncertain. Vibratory stimulation may enhance proprioceptive function; however, its efficacy in treating LBP has not been investigated. Thus, we investigated the feasibility of improving proprioceptive function and its effect on alleviating chronic LBP in older patients through targeted vibratory therapy (TVT) administration.MethodsThis single arm designed trial included older patients aged >65 years with non-specific chronic LBP. TVT involved applying vibratory stimulation, matching the frequency of dysfunctional receptors, for 1 min daily over 14 days to activate proprioceptors; patients performed TVT three times daily at home. In cases of reduced proprioceptive function at multiple sites, TVT was aimed at the lowest frequency band value. LBP and proprioceptive function were evaluated at 2 weeks after TVT and at 2 weeks after the end of TVT in patients with declined proprioception in the trunk or lower extremities.ResultsOverall, 56 patients with chronic LBP were enrolled; 32 patients were recruited for treatment based on a proprioceptive dysfunction diagnosis and 24 patients were recruited with a normal diagnosis with no significant differences observed between the two sets of patients in sarcopenia-related factors and clinical proprioception-related characteristics. No patient had any adverse events. Two weeks after TVT, the numerical pain rating scale score improved to <3 points in 78.1% of patients, with 73.1% of patients achieving a score of ≤ 3 points. Proprioceptive function improved in 81.3% of cases, and engagement in activities of daily living improved significantly.ConclusionsTVT demonstrated efficacy in improving proprioception and alleviating LBP in older patients with impaired proprioceptive function without affecting non-targeted proprioceptors.