bluuebunny/crossref_metadata_2025_split huggingface dataset:
P-303 PERCEPTION OF THE PROFESSION AND EXPERIENCE OF PHYSICIANS GRADUATING FROM THE RABAT FACULTY OF MEDICINE
Authors: Laraqui Hossini Chakib El Houssine , Manar Nadia , Bouri Hicham El , Laraqui Omar , Deschamps Frédéric 
Published: July 2024

Abstract

Introduction
The aim was to assess the perception of the profession, the experience of physicians and to offer suggestions to improve the attractiveness and practice of medicine.

Methods
This study, conducted in 2021, interested the 2,597 graduates from 1970 to 2010. An online self-questionnaire included: socio-demographic and professional data, perception of the profession, occupational experience and satisfaction, and suggestions for improving the attractiveness of medicine.

Results
1026 agreed to answer the questionnaire; i.e. a participation rate of 52.5%. The prevalence of perceived gratifying aspects and physician satisfaction was decreasing while those of constraining aspects was increasing.12.6% would change the profession, 24.6% and 47.9% of those &lt; 45 would like to move abroad. 32% would not recommend a medical career. The main suggestions for improving the attractiveness and practice of medicine: for the public sector (salary suitable, better physical and organizational working conditions), for the private sector (efficient social coverage, tax incentives and abolition of adjusted full-time) and for the both (support network for doctors, continuous medical training allowing career development and a physician’s brand image).

Discussion and Conclusion
More than 1/3 Moroccan physicians are expatriates because of dissatisfaction and professional malaise and the attractiveness of rich countries suffering from medical deserts and offering a better quality of life with more favorable working conditions, salaries more meaningful and a better future. How to encourage doctors to stay at home, those who have migrated to come back? Can we admit that our faculties of medicine train physicians of moderate quality who will complete their training and settle in rich countries?
P-314 THE RELATIONSHIP BETWEEN SELF-RATED HEALTH AND OCCUPATIONAL ACCIDENTS
Authors: Fukui Yuto , Nagata Tomohisa , Odagami Kiminori , Adi Nuri Purwito , Mori Koji 
Published: July 2024

Abstract

Introduction
Self-rated health is a subjective assessment of one’s own health status. The previous studies have shown that it is an antecedent factor of mortality, morbidity and falls in older people. However, the relationship between self-rated health and the occurrence of occupational accidents is not clear. This study aims to investigate the relationship between self-rated health and occupational accidents.

Methods
The study design was a prospective cohort study with a baseline survey in March 2022 and a follow-up survey one year later. The independent variable was self-rated health at baseline, classified into five categories. The dependent variable was the occurrence of occupational accidents from baseline to follow-up, classified into two categories: “none” and “more than once”. We examined the relationship between self-rated health and occupational accidents using logistic regression analysis. This study was approved by the Ethics Committee of UOEH.

Results
Among 16,629 workers, self-rated health was “bad/very bad” (n=662); “rather bad” (n=2,507); “rather good” (n=6,564); “good” (n=5,399); and “very good” (n=1,497). Compared to “bad/very bad” group, the odds ratios of each group were 0.69 (95%CI, 0.56-0.86), 0.40 (0.33-0.49), 0.29 (0.24-0.36), and 0.29 (0.22-0.38), respectively.

Discussion
The lower self-rated health, the more likely the worker was to have an occupational accident. This may be because physical and psychological problems cause a decline in workers’ ability to concentrate and make good decisions, leading to unsafe actions. The results of this study suggest the need for comprehensive measures to prevent occupational accidents, including the health status of workers.

Conclusion
Self-rated health influences the occurrence of occupational accidents.
P-322 WORK-RELATED FACTORS AFFECTING LIFE AND JOB SATISFACTION AMONG MEDICAL RESIDENTS
Authors: Tah Marieme , Sellami Imen , Mbeirick Mohamed , Meska Ahmed , Masmoudi Mohamed Larbi , Hammami Kaouthar Jmal , Hajjaji Mounira 
Published: July 2024

Abstract

Introduction
Medical residents (MR) are exposed to various psychosocial factors in their work environments, which can significantly influence their overall quality of life. This study aims to investigate the association between psychosocial stress at work, job satisfaction, and life satisfaction among MR.

Methods
The study was conducted from August 1 to September 5, 2023, involving 117 MR of diverse nationalities who voluntarily participated by responding to an online self-questionnaire. This questionnaire included the Karasek scale to assess psychosocial stress, the Satisfaction with Life Scale (SWLS) to measure life satisfaction, and a job satisfaction scale.

Results
The mean age of our study population was 30.61 years (± 3.961), and the male-to-female sex ratio was 1.38. Among the residents, 45.3% reported low decision latitude at work, 40.7% experienced high psychological workload, and 35% perceived inadequate collegial support. Additionally, 39.3% indicated low hierarchical support. Job satisfaction was low in 30.5% of residents, and 3.4% reported being very dissatisfied with their lives. SWLS was positively correlated with decision latitude (r=0.206; p=0.026), support from colleagues (r=0.215; p=0.020), and support from superiors (r=0.194; p=0.036). In contrast, job satisfaction exhibited a positive correlation only with decision latitude (r=0.188; p=0.042). Most notably, job satisfaction displayed a strong, positive correlation with life satisfaction (r=0.385; p&lt;0.001).

Discussion
This study emphasizes the link between job and life satisfaction, underscoring the need to address workplace factors for better well-being of MR.

Conclusion
Based on our findings, it is imperative to consider modifying the psychosocial conditions experienced by MR to enhance their satisfaction with both work and life.
P-324 OCCUPATIONAL MEDICINE TRAINING IN MOROCCO: BETWEEN THE DIVERSITY OF CURRICULA AND THE DIVERSITY OF OCCUPATIONAL HEALTH NEEDS!
Authors: Tahri Loubna , Wifaq Kamal , Soltani Sara , El Kholti Abdeljalil 
Published: July 2024

Abstract

Introduction
Morocco’s economic and industrial fabric has undergone remarkable change in recent years, with the arrival of several multinationals and the development of service professions. In view of the ratification of ILO C187, occupational medicine in Morocco faces the dilemma of competences and occupational safety and health (OSH) requirements.

Methods
this study provides an overview of the various training courses for occupational physicians in Morocco, as well as the ways in which the specialty is practiced in Morocco, followed by a study of the adaptability of skills to the regulatory and normative requirements of OSH.

Discussion and results
Morocco’s working population is around 12.2 million and the national profile shows that occupational health services cover 20% of the country’s population, while the number of occupational physicians exceeds 1,400. This indicates a disparity in the way occupational medicine is practiced: many qualified physicians do not work in companies, while others devote only part of their time to their work, and there are very few full-time occupational physicians. The aim of our work is to suggest ways of improving occupational health coverage, while at the same time improving the working conditions of occupational physicians.

Conclusion
There are multiple ways to practice Occupational medicine, but the recommendations are geared towards proposing models of multidisciplinary occupational health services, distributed according to economic zone and number of employees. This model can also be offered to the public sector, providing services that are almost non-existent as yet.
P-329 INTEREST OF MEDICAL DIGITALIZATION IN OCCUPATIONAL MEDICINE
Authors: Errida Samir 
Published: July 2024

Abstract

Introduction
This study aimed to collect precise data as reported in medical records, including the number of workplace accidents, their causes, types, and severity. It also sought information on the duration of work interruptions and compared them with other types of injuries.

Methods
The study gathered data on the rates of Permanent Partial Disability (IPP) granted and aimed to understand the assessment of clinical and para clinical care costs, as well as compensation amounts for different reported incidents.

Results
The digitalization of medical records offered several advantages, such as eliminating the need to physically transfer records between company branches, systematic archiving in the company’s drive with immediate retrieval when needed, and enabling the declaration of changes in job positions and scheduling of medical examinations. The digitalization of medical records led to improved access for authorized personnel, including occupational physicians and nursing staff, with enhanced data privacy protection.

Discussion
This streamlined data exchange and document sharing exclusively among the company’s occupational physicians, resulting in increased efficiency in accessing healthcare services and improving overall medical care management within the organization. Furthermore, the ability to compare and analyze data on workplace accidents, work interruptions, and compensation rates can aid in identifying trends and implementing preventive measures.

Conclusion
This digitalization process enhances data accessibility, privacy protection, and the efficiency of medical care management within the organization.
P-334 TITLE: NATIONAL POLICY INDEX (NPI) FOR WORKER MENTAL HEALTH AND ITS RELATIONSHIP WITH ENTERPRISE PSYCHOSOCIAL SAFETY CLIMATE
Authors: Potter R , Dollard M F , Lerouge L , Jain A , Leka S , Cefaliello A 
Published: July 2024

Abstract

Introduction
National occupational health and safety (OHS) policy (e.g., legislation) underpins worker health protection and is imperative for healthy and safe working populations. In the interest of bolstering mental health through decent work, this study undertakes a global analysis of OHS policy for worker mental health and develops and validates a short tool quantifying national policy approaches—the National Policy Index (NPI, for worker mental health).

Method
Data were collected across 45 countries from 164 global experts (and/or expert groups) to capture policy presence, priority action areas, and drivers and barriers surrounding policy implementation.

Results
Analysis revealed top global psychosocial concerns are harassment, mobbing or bullying, work overload, discrimination, and poor work-life balance. Policy priorities are harassment, mobbing or bullying, discrimination, and physical violence. The psychosocial hazards/risks that are most addressed in policies or regulated are physical violence, discrimination, harassment, mobbing or bullying. The main driver for managing hazards is workplace senior management support and having specific national regulations, and the main barrier is poor resource availability.

Discussion
The NPI was developed through exploratory factor analysis and validated through significant correlation with a national policy audit and to the 2019 European Survey of Enterprises on New and Emerging Risks data, which reports enterprise level psychosocial safety climate (PSC, organisational policies, and procedures for stress prevention). The correlation between the NPI and enterprise-level PSC highlights the critical role of national policy in protecting worker population mental health. Yet above and beyond national policy, national union density also related to enterprise PSC indicating that social action is also imperative.

Conclusion
Findings suggest that global mental health can be reinforced via decent work outlined in national policy approaches, particularly legislation, as well as via senior management support, and collective approaches such as union action.
P-337 EXPERIENCE IN OCCUPATIONAL MEDICINE PRACTICE DURING COVID-19 AT PRIVATE HOSPITAL, THAILAND
Authors: Karnjanakantorn Worrapan 
Published: July 2024

Abstract

Introduction
The COVID-19 pandemic, also known as the coronavirus pandemic. Thailand was the first country to report a case outside China. As of 2 April 2022, the country has reported a cumulative total of 3,684,755 confirmed cases, with 25,318 deaths from the disease.

Methods
To Study in high risk worker with underlying medical conditions during 2020-2022.There were many activities to prevent infection e.g. occupational health consultation, periodic examination, cleaning workplaces, also recommendations from Department of Disease Control including 1) Before working, they must prepare a cloth mask, hygienic mask, alcohol gel 2) Do not share their personal belongings with others such as glasses, food containers 3) If they have symptoms, they must take a leave of absence at home and inform their boss of health condition 4) If they find that a colleague in the workplace has an abnormal cough, they had to inform the first aid station in their office

Results
There were 35 people who had underlying condition. They might have more than one and sometimes two or three of underlying conditions, Diabetes(4 people), Hypertension, Heart condition(15 people), Respiratory disease(4 people),Liver disease(1 person), Immunocompromised(1 person), Other conditions, Gout, Anemia (14 people) all cases need to assess individual risk e.g. Past medical history, Underlying conditions, Current medications and Annual check-up. There was no COVID-19 case during the study.

Discussion
We should take particular care to reduce workers’ risk of exposure to COVID-19.

Conclusion
The high-risk group workers were encouraged to get booster vaccinated as soon as possible and early detection was necessary to prevent COVID-19.
P-338 ANALOGOUS SLAVE LABOR IN BRAZIL: A COMPLEX REALITY TO BE ANALYZED BY OCCUPATIONAL HEALTH
Authors: Ximenes Catiane , Setubal Aline , Oliveira Paulo 
Published: July 2024

Abstract

Introduction
The interest in work throughout the production chain brought about by Industry 5.0 can contribute to combating forms of labor exploitation. Occupational health is a tool that has technical and scientific foundations to help with this problem. Objectives: To draw up a profile of analogous slave labor in Brazil.

Methods
Using the websites of the Ministry of Labor, Social Security, the Public Ministry of Labor, RadarSIT and SmartLab, it was possible to trace the profile of analogous slave labor in Brazil. The paper Industry 5.0 Towards a sustainable, human-centered and resilient European industry 2021 identified the contributions of industry 5.0.

Results
From 1995 to June 14, 2023, 61,711 workers were found in these conditions in Brazil. Between 2002 and 2022, the five economic sectors most involved were cattle breeding (27%), sugar cane (15%), forestry production (8%), coffee growing (6%) and alcohol manufacture and building construction (4% each). 88% had completed elementary school, 93% were men and aged between 18 and 39.

Discussion and Conclusion
Labor slavery is still present in Brazil and occupational health is a tool that could be used more by public policies. The state in Brazil where these workers were most commonly found is part of the region of the country where there is no medical residency in occupational medicine. The occupational physician must recognize these conditions, treat and prevent further damage from being caused, allied to the innovations of industry 5.0, in the search for solutions to health problems.
P-339 OCCUPATION AND RISK OF CHOLANGIOCARCINOMA IN THE CARA CASE-CONTROL STUDY
Authors: Mattioli Stefano , Nocilla Mattia Roberto , Montagnani Andrea , Murgia Nicola , Tavolari Simona , Deserti Marzia , Curti Stefania 
Published: July 2024

Abstract

Introduction
The association between cholangiocarcinoma (CC) and occupational exposure to asbestos and chlorinated solvents has been studied. This study aims to evaluate whether there is an increased risk of CC in specific occupational categories.

Methods
Case and control subjects of the CARA (Cholangiocarcinoma Aetiology: Role of Asbestos) study were grouped in occupational categories according to ISCO-88 classification. We fitted multivariate logistic regression models to estimate Odds Ratios (OR) and 95% confidence intervals (CI) adjusting for gender, age, comorbidities, smoking habits, and familiarity. Subgroup analyses were performed among idiopathic subjects. The reference category comprised administrative clerks and other white-collar workers.

Result
We found an increased risk for CC in “agricultural workers” (OR 3.4, 95%CI 1.2-9.1) and “typographers/painters” (OR 5.1, 95%CI 0.9-27.7). The risk for “sales workers” and “service sector workers” was 0.5 (95%CI 0.3-0.9) and 0.3 (95%CI 0.1-0.9), respectively. Among subjects without comorbidities, the risk for CC was increased for “construction workers” (OR 4.9, 95%CI 1.2-20.0).

Discussion
Occupational exposure to asbestos is common among agricultural and construction workers, while typographers/painters are likely to be exposed to solvents. The absence of occupational exposure to risk factors along with the role of socioeconomic conditions could help explaining the reduction of risk for CC in some occupational categories.

Conclusion
Our results supported the association between asbestos and solvents and the risk of CC. Further studies are needed to reinforce the hypothesis of the association between occupational (and non-occupational) risk factors for CC.
O-191 OCCUPATIONAL EXPOSURE TO PERFLUOROALKYL SURFACTANTS PFOA, ADV AND CC6O4 IN ITALIAN POLYMERS PLANTS AND THEIR KINETICS OF ELIMINATION
Authors: Fustinoni Silvia , Mercadante Rosa , Cafagna Simone , Campo Laura , Consonni Dario 
Published: July 2024

Abstract

Introduction
Perfluoroalkyl acid surfactants PFOA (from the sixties to 2013) and ADV (since 1996) were historically used in two Italian fluoropolymer plants; cC6O4 was introduced in 2012 as a PFOA substitute. This work reports biomonitoring results in the years 2004-2021.

Methods
Workers surveyed from 2004, measuring serum concentrations of perfluoroalkyl acid surfactants. For PFOA and cC6O4, the kinetics of elimination was investigated.

Results
809 workers were investigated for PFOA (3,692 samples), ADV (4,288 samples) and cC6O4 (2,272 samples). In the production plant, median PFOA decreased from 1900 to 14 µg/L (2004-2021); median ADV from 434 to 86 µg/L (2011-2021). For cC6O4 the detection ranged from 9 to 47% (2013-2021), while in detected samples median cC6O4 ranged from 3 to 16 µg/L. Several mitigation measurements were adopted, including the phasing out of PFOA and plant improvements. Decreasing trends were observed for all chemicals along years (p value for linear trend of means &lt;0.001). After the ban of PFOA, a half-live of 3.16 (95% confidence interval: 2.98 – 3.37) years was calculated with data from 93 workers/568 samples. In 18 workers cC6O4 half-life was 7.7 (95% CI: 6.7 – 8.9) days.

Discussion
PFOA and ADV markedly decreased over time. The apparent increase of Cc6O4 was due to changes in laboratory limits of quantification over time.

Conclusion
Technical and organizational interventions undertaken to reduce exposure were effective, with a 5 to 136-fold reduction in the concentration of perfluoroalkyl compounds in the serum of workers. While PFOA is a persistent compound, cC6O4 has a much shorter half-live.
O-193 THE SAFECHROM PROJECT - CIRCULATING LUNG-CANCER-RELATED NON-CODING RNAS ARE ASSOCIATED WITH OCCUPATIONAL EXPOSURE TO HEXAVALENT CHROMIUM
Authors: Jiang Zheshun , Person Romane , Abushanab Heam , Pineda Daniela , Lundh Thomas , Engfeldt Malin , Broberg Karin 
Published: July 2024

Abstract

Introduction
Hexavalent chromium, Cr(VI), is classified as a Group 1 human carcinogen and causes lung cancer. This study was to investigate associations between occupational exposure to Cr(VI) and lung cancer-related non-coding RNAs.

Methods
The study included 111 Cr(VI) exposed workers and 72 controls in Sweden, 91.4% non-smokers. Cr concentration in red blood cells (RBC-Cr) was measured. MicroRNA (miRNA) and long non-coding RNA (lncRNA) were extracted from plasma followed by DNAse treatment, cDNA synthesis, and qPCR using target-specific assays for four miRNAs (miR-142-3p, miR-15b-5p, miR-3940-5p, miR-451a), and three lncRNAs (H19, MALAT1, NORAD).

Results
Median RBC-Cr concentrations were significantly higher in the exposed group (0.73 µg/L, 5-95% 0.51-2.33) compared with controls (0.53 µg/L, 0.42-0.72). Plasma relative expression levels of all miRNAs, MALAT1 and NORAD were significantly lower in the exposed workers compared with controls. In the exposed group, significant negative correlations (rS=-0.19 - -0.27) were found between RBC-Cr and miR-142-3p, miR-15b-5p, miR-451a and NORAD. NORAD correlated with miR-142-3p (rS=0.34) and miR-15b-5p (rS=0.28). In multivariate regression models adjusting for confounders, expression of the miRNAs, MALAT1 and NORAD was still significantly lower in the exposed group compared with controls, and the expression decreased with increasing RBC-Cr.

Discussion
Cr(VI) exposure was associated in a dose-response manner with differential expression of circulating non-coding RNAs in exposed workers, which suggests non-coding RNAs as potential toxicological biomarkers for Cr(VI). Relations between miRNAs and lncRNAs suggest that they participate in the same lncRNA-miRNA-mRNA regulatory axes, which may play important roles in Cr(VI) carcinogenesis.

Conclusion
Occupational Cr(VI) exposure may impact circulating lung-cancer-related non-coding RNAs expression.
P-344 MECHANISM OF 1,2-DICHLOROPROPANE-INDUCED CHOLANGIOCARCINOMA
Authors: Ichihara Gaku , Zong Cai , Kimura Yusuke , Ekuban Abigail , Takizawa Ryoya , Kinoshita Kazuo , Sugie Shigeyuki , Zhang Xiao , Zhang Lingyi , Itoh Ken , Yamamoto Masayuki , Shichino Shigeyuki , Matsushima Kouji , Ichihara Sahoko 
Published: July 2024

Abstract

Introduction
In 2013, a case series of cholangiocarcinoma was reported among offset color proof-printing workers, and 1,2-dichloropropane was identified as the causative agent.

Material and Method
Subsequent histopathological studies on surgically resected specimens of cholangiocarcinoma from workers exposed to 1,2-dichloropropane revealed hyperplasia or sclerosis of the bile duct and variable inflammatory cell proliferation in noncancerous hepatic tissues.

Result and discussion
Additionally, an increase in expression of gamma-H2AX, a marker of DNA double-strand breaks, was observed in non-neoplastic biliary epithelial cells. Experimental investigations using Nrf2-knockout mice demonstrated that exposure to 1,2-dichloropropane induced cholangiocyte proliferation and exerted an anti-apoptotic effect. Moreover, an upregulation of gamma-H2AX expression was observed in the livers of wild-type mice, but not of Nrf2-knockout mice, indicating a Nrf2-dependent induction of DNA damage. In vitro studies using human MMNK-1 cholangiocytes exposed to 1,2-dichloropropane did not result in an increase of gamma-H2AX-positive foci, gene expression of activation-induced cytidine deaminase (AID), or ROS production. However, when co-cultured with THP-1 derived macrophages, MMNK-1 cells exhibited all of these changes related to genomic instability. Subsequent transcriptome analysis revealed that exposure to 1,2-dichloropropane upregulated base excision repair genes in cholangiocytes co-cultured with macrophages, but not in monocultured cholangiocytes. These findings collectively suggest a role of Nrf2 in cell proliferation and anti-apoptotic effects in cholangiocytes, as well as the induction of DNA damage in mice. Furthermore, the study highlights the pivotal role of macrophages in the induction of DNA damage, upregulation of AID, or ROS production in human cholangiocytes.

Conclusion
our study demonstrates the Nrf2 and inflammatory cell-mediated mechanism of 1,2-dichloropropane-induced carcinogenesis in cholangiocarcinoma.