bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONFLICT OF REALITY AND FANTASTIC FICTION IN THE STORY OF ALEXEY N. TOLSTOY “COUNT CALIOSTRO”
Authors: Kiryukhina Elena M. 
Published: July 2024

The article examines the story “Count Cagliostro” by Alexei Nikolaevich Tolstoy, completed during the emigration period: based on a real historical fact (the visit to Russia in 1779-1780 of the Italian adventurer Giuseppe Balsamo, who called himself Count Cagliostro), it combines reality with fantastic fiction, and turning to works using a fantastic element is very relevant today. At first glance, the complex vicissitudes of life should have determined the preference of fantasy over reality, but in “Count Cagliostro” fantastic fiction enters into a conflicting relationship with the world of reality, proof of this thesis becomes the purpose of the article. Using problematic, comparative-contrastive, cultural-historical, chronological, and biographical methods, the author solves the goal by comparing “Count Cagliostro” with the story written at the same time – A.N. Tolstoy’s “Nikita’s Childhood” and the previously created poem by A.K. Tolstoy – “Portrait”, a simultaneous comparison of these works has not been previously made and represents the scientific novelty of the presented article. The author comes to the conclusion that in difficult times of moral searches A.N. Tolstoy does not want to hide from life’s problems in the world of a fantasy universe; the conflict between reality and fantastic fiction is resolved in favor of the triumph of real earthly love. This ability to prefer harsh reality to fairy-tale fiction will affect both the subsequent work and the life path of A.N. Tolstoy.
Utilising deep learning networks to classify ZEB2 expression images in cervical cancer
Authors: Zheng Chenyang , Shen Qinqin , Zhao Lingjun , Wang Yijun 
Published: July 2024

Aims/Background Cervical cancer continues to be a significant cause of cancer-related deaths among women, especially in low-resource settings where screening and follow-up care are lacking. The transcription factor zinc finger E-box-binding homeobox 2 (ZEB2) has been identified as a potential marker for tumour aggressiveness and cancer progression in cervical cancer tissues. Methods This study presents a hybrid deep learning system developed to classify cervical cancer images based on ZEB2 expression. The system integrates multiple convolutional neural network models—EfficientNet, DenseNet, and InceptionNet—using ensemble voting. We utilised the gradient-weighted class activation mapping (Grad-CAM) visualisation technique to improve the interpretability of the decisions made by the convolutional neural networks. The dataset consisted of 649 annotated images, which were divided into training, validation, and testing sets. Results The hybrid model exhibited a high classification accuracy of 94.4% on the test set. The Grad-CAM visualisations offered insights into the model's decision-making process, emphasising the image regions crucial for classifying ZEB2 expression levels. Conclusion The proposed hybrid deep learning model presents an effective and interpretable method for the classification of cervical cancer based on ZEB2 expression. This approach holds the potential to substantially aid in early diagnosis, thereby potentially enhancing patient outcomes and mitigating healthcare costs. Future endeavours will concentrate on enhancing the model's accuracy and investigating its applicability to other cancer types.
Semi-automatic line-system provisioning with an integrated physical-parameter-aware methodology: field verification and operational feasibility
Authors: Nishizawa Hideki , Borraccini Giacomo , Sasai Takeo , Huang Yue-Kai , Mano Toru , Anazawa Kazuya , Namiki Masatoshi , Usui Soichiroh , Matsumura Tatsuya , Sone Yoshiaki , Wang Zehao , Okamoto Seiji , Inoue Takeru , Ip Ezra , D’Amico Andrea , Chen Tingjun , Curri Vittorio , Wang Ting , Asahi Koji , Takasugi Koichi 
Published: July 2024

We propose methods and an architecture to conduct measurements and optimize newly installed optical fiber line systems semi-automatically using integrated physics-aware technologies in a data center interconnection (DCI) transmission scenario. We demonstrate, for the first time to our knowledge, digital longitudinal monitoring (DLM) and optical line system (OLS) physical parameter calibration working together in real-time to extract physical link parameters for fast optical fiber line systems provisioning. Our methodology has the following advantages over traditional design: a minimized footprint at user sites, accurate estimation of the necessary optical network characteristics via complementary telemetry technologies, and the capability to conduct all operation work remotely. The last feature is crucial, as it enables remote operation to implement network design settings for immediate response to quality of transmission (QoT) degradation and reversion in the case of unforeseen problems. We successfully performed semi-automatic line system provisioning over field fiber network facilities at Duke University, Durham, North Carolina. The tasks of parameter retrieval, equipment setting optimization, and system setup/provisioning were completed within 1 h. The field operation was supervised by on-duty personnel who could access the system remotely from different time zones. By comparing Q-factor estimates calculated from the extracted link parameters with measured results from 400G transceivers, we confirmed that our methodology has a reduction in the QoT prediction errors ( ±0.3dB ) over existing designs ( ±0.6dB ).
UK and US risk factors for hearing loss in neonatal intensive care unit infants
Authors: Thornton Sally K. , Hoare Derek J. , Yates Alice M. , Willis Karen R. , Scutt Polly , Kitterick Padraig T. , Dixit Abhijit , Jayasinghe Dulip S. 
Published: July 2024

Importance
Early detection and intervention of hearing loss may mitigate negative effects on children’s development. Children who were admitted to the neonatal intensive care unit (NICU) as babies are particularly susceptible to hearing loss and risk factors are vital for surveillance.

Design, setting and participants
This single-centre retrospective cohort study included data from 142 inborn infants who had been admitted to the NICU in a tertiary regional referral centre. Data were recorded for 71 infants with confirmed permanent congenital hearing loss hearing loss. To determine impact of NICU admission independently of prematurity, babies were individually matched with 71 inborn infants on gestational age, birthweight, and sex.

Main outcomes and measures
Neonatal indicators were recorded for all children with permanent congenital hearing loss. Presence of UK and US risk factors for hearing loss were collected on the neonatal population with hearing loss and for the matched controls.

Results
A fifth (21%) of babies with hearing loss had one or more UK risk factors whereas most (86%) had at least one US risk factor. False positives would be evident if US factors were used whereas the matched controls had no UK risk factors. Ten babies who at birth had no UK or US risk factors did not have any significant neonatal indicators identified in their records, one was ventilated for one day and two had a genetic anomaly.

Conclusions and relevance
Current risk factors for hearing loss we identified for follow-up in this high-risk group are highly specific for congenital hearing loss. UK risk factors were highly specific for hearing loss but not sensitive and conversely, US risk factors are sensitive but not specific so false positives would be recorded. A national study of neonatal indicators could provide the utility to test which combinations of risk factors provide high sensitivity without losing specificity.
Characteristics, demographics, and epidemiology of possible chronic cough in Sweden: A nationwide register-based cohort study
Authors: Walz Lotta , Illergård Kristoffer , Arpegård Johannes , Dorbesi Cristian , Johansson Henrik , Ingi Emilsson Össur 
Published: July 2024

Aim
To show clinical characteristics, treatments, and comorbidities in chronic cough in a nationwide cohort.

Methods
Two cohorts were created. A national cohort with individuals from two population-based databases; the National Patient Register and Swedish Prescribed Drug Register. Secondly, a regional cohort including primary care data. Adults with at least one cough diagnosis (ICD-10 R05) and/or individuals with ≥2 dispensed prescriptions for relevant cough-medication within the inclusion period, 2016–2018, were identified. Individuals on medications which may instigate cough or suggest acute infection or diagnosed with conditions where cough is a cardinal symptom, were excluded. Those remaining were defined as having possible refractory or unexplained chronic cough (RCC/UCC).

Results
Altogether 62,963 individuals were identified with possible RCC/UCC, giving a national prevalence of about 1%. Mean age was 56 years and 60% were females. Many (44%) of the individuals with possible RCC/UCC visited cough relevant specialist clinics during the study period, but less than 20% received a cough diagnosis. A majority (63%) had evidence of RCC/UCC in the 10 years prior to inclusion in the study. In the regional cohort, including primary care data, the prevalence of RCC/UCC was doubled (2%). Cough medicines were mainly prescribed by primary care physicians (82%).

Conclusion
Most individuals with possible RCC/UCC sought medical care in primary care, and had a long history of cough, with various treatments tried, indicating a substantial burden of the condition. Referrals to specialist care were very rare. The results underline the need for a structured multidisciplinary approach and future therapeutic options.
Detection through the use of RT-MqPCR of asymptomatic reservoirs of malaria in samples of patients from the indigenous Comarca of Guna Yala, Panama: Essential method to achieve the elimination of malaria
Authors: Cáceres Carrera Lorenzo , Santamaría Ana María , Castillo Anakena Margarita , Romero Luis , Urriola Eduardo , Torres-Cosme Rolando , Calzada José Eduardo 
Published: July 2024

Background
Plasmodium vivax is the main causative agent of malaria in Panama. However, the prevalence of asymptomatic infections in the different endemic regions remains unknown. Understanding the epidemiological behavior of asymptomatic infections is essential for the elimination of malaria. This study aimed to determine the prevalence of asymptomatic malarial infections in one of the main endemic regions of Panama using multiplex real-time reverse transcription RT-MqPCR.

Methods
A cross-sectional study was conducted in three communities in the Guna Yala Comarca. A total of 551 thick blood smears and their respective samples on filter paper were collected from volunteers of different ages and sexes from June 20 to 25, 2016. Infections by the Plasmodium spp. were diagnosed using microscopy and RT-MqPCR. All statistical analyses were performed using the R software.

Results
The average prevalence of asymptomatic infections by P. vivax in the three communities detected by RT-MqPCR was 9.3%, with Ukupa having the highest prevalence (13.4%), followed by Aidirgandi (11.1%) and Irgandi (3.3%). A total of 74 samples were diagnosed as asymptomatic infections using RT-MqPCR. Light microscopy (LM) detected that 17.6% (13/74) of the asymptomatic samples and 82.4% (61/74) were diagnosed as false negatives. A 100% correlation was observed between samples diagnosed using LM and RT-MqPCR. A total of 52.7% (39/74) of the asymptomatic patients were female and 85.1% (63/74) were registered between the ages of 1 and 21 years. Factors associated with asymptomatic infection were community (aOR = 0.38 (95% CI 0.17–0.83), p < 0.001) and age aOR = 0.98 (95% CI 0.97–1.00), p < 0.05); F = 5.38; p < 0.05).

Conclusions
This study provides novel evidence of the considerable prevalence of asymptomatic P. vivax infections in the endemic region of Kuna Yala, representing a new challenge that requires immediate attention from the National Malaria Program. The results of this study provide essential information for the health authorities responsible for developing new policies. Furthermore, it will allow program administrators to reorient and design effective malaria control strategies that consider asymptomatic infections as a fundamental part of malaria control and move towards fulfilling their commitment to eliminate it.
Abwägung, Alternativen und Varianten in kommunalen Planungsprozessen. Grundsätzliche Überlegungen und Ergebnisse einer empirischen Untersuchung
Authors: Müller Christin , Bongers-Römer Sabine , Bakunowitsch Julija , Diller Christian 
Published: July 2024

Balancing in general and balancing alternatives and variants can be seen as a core component of the work of planners. Against the backdrop of current social challenges, the complexity of these balancing processes is increasing. From a planning science perspective, however, the question of the balancing process has only begun to be analysed. To date, there are only a few empirical studies that have explicitly focussed on balancing processes in Germany. This is where this paper starts by focusing on urban planning, investigating what planners understand by balancing alternatives and variants and how the balancing process is presented in everyday planning. To this end, 19 qualitative interviews were conducted with public and private sector planners. A qualitative content analysis was used to analyse the data. The results confirm the central role of balancing processes in everyday planning and emphasise the need for further research to understand these processes’ complexity and significance.
Prognostic value and microenvironmental crosstalk of exosome-related signatures in human epidermal growth factor receptor 2 positive breast cancer
Authors: Zhao Ji , Shen Feng , Hu Yue-Mei , Yin Kai , Chen Ying , Chen Yan-Jie , Hu Qun-Chao , Liang Li 
Published: July 2024

Abstract
This study aimed to determine the prognostic value and microenvironmental crosstalk of exosome-related signatures in human epidermal growth factor receptor 2 positive breast cancer (HER2+ BC). Transcriptome sequencing and clinicopathological data were downloaded from the Cancer Genome Atlas. The 10X single cell sequencing dataset was downloaded from the National Center for Biotechnology Information Gene Expression Omnibus. Exosomes-Related Genes were extracted from the ExoCarta and Gene Set Enrichment Analysis databases. FGF9, SF3B4, and EPCAM were found and deemed the most accurate predictive signatures. Patients with HER2+ BC were subtyped into three groupings by exosome prognostic gene (EPGs). The expression of SF3B4 was positively linked with the infiltration of macrophages, neutrophils, and CD4+ T cells. The expression characteristics of EPGs were associated with the biological process of “response to xenobiotic stimuli.” Interactions were relatively high between malignant epithelial cells and fibroblasts, endothelial cells, monocytes, and macrophages. Malignant epithelial cells interact more with fibroblasts and endothelial cells. The migration inhibitory factor pathway was the primary outgoing signaling pattern, while the C-C motif chemokine ligand pathway was the primary incoming signaling pattern for communication between malignant epithelial cells and macrophages. This study described the role of exosome signatures in the prognosis and microenvironment of HER2+ BC and provided a basis for future research.
Predictive value of serum magnesium levels for prognosis in patients with non-small cell lung cancer undergoing EGFR-TKI therapy
Authors: Xu Fang-Zhou , Meng Fu-Rong , Li Wan-Jing , Xu Lu , Zhang Hao , Zhang Yan-Bei , Fan Xiao-Yun 
Published: July 2024

Abstract
The aim of this study is to assess the impact of serum magnesium (Mg) levels on prognostic outcomes in patients with non-small cell lung cancer (NSCLC) undergoing treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). A cohort comprising 91 patients with NSCLC with epidermal growth factor receptor mutations received EGFR-TKI therapy. Assessments of liver and kidney function and electrolyte levels were conducted before treatment initiation and after completing two cycles of EGFR-TKI therapy. Data on variables such as age, gender, presence of distant metastasis, smoking history, other therapeutic interventions, and the specific TKI used were collected for analysis. Cox regression analysis revealed that patients with higher Mg levels prior to EGFR-TKI therapy had significantly longer progression-free survival (PFS) and overall survival (OS). Elevated Mg levels remained predictive of PFS and OS after two cycles of EGFR-TKI therapy. Multiple regression analysis confirmed these findings. Additionally, it was observed that smokers might represent a unique population, demonstrating a correlation between OS and Mg levels. Our findings indicate that serum Mg level is a prognostic factor in patients with NSCLC undergoing EGFR-TKI therapy. This may provide new insights into the underlying mechanisms of EGFR-TKI therapy related to electrolyte balance.
Usability of PPGIS tools exemplified by geodiscussion – a tool for public participation in shaping public space
Authors: Młodkowski Marek , Jankowski Piotr 
Published: July 2024

Abstract
The article explores the usability of the geodiscussion administrative panel, an online tool aiding Public Participation Geographic Information Systems. This tool was specifically designed and developed for distribution in a Software as a service model, offering geodiscussion users the flexibility to leverage the tool without the need for substantial investments in expensive infrastructure or complex deployments. The research primarily centers on the geodiscussion administrative panel, a key component empowering organizers of public consultations in spatial planning to efficiently create and manage consultation processes. In contrast to previous studies that focused on the usability for consultation participants, this research uniquely targets individuals responsible for organizing and overseeing the consultation processes. A diverse array of usability research methods were employed, ranging from the creation of personas and conducting direct interviews based on test scenarios to non-invasive methods for recording user activities. The study involved 682 participants who had prior experience with public consultations across various public administration units and representatives from consulting firms. Given that the usability studies were an integral part of the geodiscussion administrative panel’s development process, the research team has the opportunity to influence the further implementation of the applied functionalities. This implies that insights gained from the research can actively shape and enhance the tool’s features as it progresses in its development cycle.
Study on the adsorption performance of zeolite imidazole frameworks materials for Co(II) and Mn(II) in solution
Authors: Bao Ping , Zhou Yipeng , Wang Xiaowei , Men Jinfeng , Liang Chengqiang , Ding Hao 
Published: July 2024

Abstract
The radionuclides 60Co and 54Mn are the main activation products produced in the operation of nuclear power facilities. Wastewater with these radionuclides must be treated to meet standards before being discharged. A variety of zeolite imidazole frameworks (ZIFs) materials were synthesized at room temperature, and the adsorption effect of ZIF-67 was found to be the best through adsorption experiments on Co(II) and Mn(II). The thermal stability test and structural characterization of ZIF-67 were carried out. At the same time, the influence of the initial pH value, adsorption time, and initial concentration of the solution on the adsorption of Co(II) and Mn(II) by ZIF-67 was investigated. The results show that: ZIF-67 has a microporous structure with a BET surface area of 1,035.72 m2/g. In addition, ZIF-67 has good thermal stability, under the condition of pH = 6, a temperature of 303 K and the initial concentration of 500 mg/L. The saturated adsorption capacity for Co(II) and Mn(II) reached 230.25 mg/g and 338.75 mg/g, respectively. ZIF-67 exhibits good selective adsorption performance for Co(II) and Mn (II) in high concentration interfering ion solutions and multi-ion solutions. The adsorption process of ZIF-67 was analyzed by kinetics, thermodynamics, isotherms, and adsorption diffusion models. The analysis of thermodynamic parameters shows that the adsorption process of ZIF-67 to Co(II) and Mn(II) is spontaneous and endothermic. The pseudo-second-order kinetic model, Langmuir isotherm model, and Boyd model are more in line with the adsorption process of Co(II) and Mn(II) by ZIF-67. It shows that the active sites on the surface of ZIF-67 are evenly distributed, and the adsorption process is single-molecule chemical layer adsorption. In addition, the liquid film diffusion dominates the adsorption rate during the adsorption process of Co(II) and Mn(II) by ZIF-67.
Are calves trainable? Low-intensity calf muscle training with or without blood flow restriction: a randomized controlled trial
Authors: Gavanda Simon , Eisenkolb Matthias , Held Steffen , Geisler Stephan , Gehlert Sebastian 
Published: July 2024

Abstract

Objectives
Whether low-load resistance training (RT) without muscle failure, with or without blood flow restriction (BFR), is sufficient to increase strength and muscle growth of calf muscles in trained individuals is still unclear. This study aimed to compare the effects of low-intensity BFR RT vs. traditional low-intensity RT (noBFR) with moderate training volume on strength and circumference.

Methods
We designed a parallel, randomized controlled trial including 36 RT-trained participants (BFR: 7 females, 32.9 ± 8.8 years, 11 males, 28.4 ± 3.6 years; noBFR; 8 females, 29.6 ± 3.4 years; 10 males, 28.6 ± 4.9 years) who underwent eight weeks of twice-weekly low-load RT with a total of 16 RT sets (30 % of one-repetition maximum [1RM]). RT consisted of bilateral calf raises and seated unilateral calf raises, each conducted with 4 sets (30, 15, 15, 15 repetitions not to failure) of either BFR or noBFR. Outcome measures included calf circumference (CC), leg stiffness (LS), and various strength tests (seated and standing calf raise 1RM, isokinetic strength of plantar- and dorsiflexion).

Results
There were no significant interactions or group effects for most measures. Both groups showed significant improvements in seated calf raise strength (p=0.046, η
2
p=0.17). Pairwise comparisons indicated moderate to large effect sizes for strength improvements (standardized mean differences: 0.35–1.11), but no changes in calf circumference were observed in either group.

Conclusions
Low-load RT with and without BFR are useful to increase strength without necessarily affecting hypertrophy. Low-intensity BFR training did not confer additional benefits over traditional low-intensity RT for calf muscle strength or circumference, questioning its general advantage under such conditions.