bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Initial Conditions in N-Body Simulations of Debris Discs
Authors: Thilliez E. , Maddison S. T. 
Published: October 2015

AbstractNumerical simulations are a crucial tool to understand the relationship between debris discs and planetary companions. As debris disc observations are now reaching unprecedented levels of precision over a wide range of wavelengths, an appropriate level of accuracy and consistency is required in numerical simulations to confidently interpret this new generation of observations. However, simulations throughout the literature have been conducted with various initial conditions often with little or no justification. In this paper, we aim to study the dependence on the initial conditions of N-body simulations modelling the interaction between a massive and eccentric planet on an exterior debris disc. To achieve this, we first classify three broad approaches used in the literature and provide some physical context for when each category should be used. We then run a series of N-body simulations, that include radiation forces acting on small grains, with varying initial conditions across the three categories. We test the influence of the initial parent body belt width, eccentricity, and alignment with the planet on the resulting debris disc structure and compare the final peak emission location, disc width and offset of synthetic disc images produced with a radiative transfer code. We also track the evolution of the forced eccentricity of the dust grains induced by the planet, as well as resonance dust trapping. We find that an initially broad parent body belt always results in a broader debris disc than an initially narrow parent body belt. While simulations with a parent body belt with low initial eccentricity (e ~ 0) and high initial eccentricity (0 < e < 0.3) resulted in similar broad discs, we find that purely secular forced initial conditions, where the initial disc eccentricity is set to the forced value and the disc is aligned with the planet, always result in a narrower disc. We conclude that broad debris discs can be modelled by using either a dynamically cold or dynamically warm parent belt, while in contrast eccentric narrow debris rings are reproduced using a secularly forced parent body belt.
La Villa di Lucio Vero sulla Via Cassia a Roma in località Acquatraversa
Authors: Caserta Emmanuela 
Published: October 2015

Villam praeterea extruxit in via Clodia famosissimam, in qua per multos dies et ipse ingenti luxuria debacchatus est cum libertis suis et amicis Paridis, quorum praesentia<e> <n>ulla inerat reverentia, et Marcus rogavit, qui venit, ut fratri venerabilem morum suorum et imitandam ostenderet sanctitudinem, et quinque diebus in eadem villa residens cognitionibus continuis operam dedit, aut convivante fratre aut convivia comparante. (HA Verus 8.8, ed. Hohl [Lipsiae 1955] 80–81)Con queste parole il biografo della vita di Lucio Vero, nella Historia Augusta, documenta la presenza di una dimora di notevoli proporzioni e magnifico aspeto fata costruire dall’imperatore, coreggente con il fratello Marco Aurelio tra il 161 e il 169, sul tracciato della via Clodia/Cassia nel II sec. d.C. (fig. 1). Non sono molti i luoghi che, lungo la strada consolare, possono essere a ragione inseriti nelle proprietà imperiali per imponenza delle struture e ricchezza dei reperti custoditi; così i resti da sempre visibili al V miglio della strada, in località Acquatraversa, su una modesta altura che domina la valle (89 m s.l.m. è il punto più alto a nord-ovest), sono ormai riconosciuti in modo unanime dagli studiosi come appartenenti al complesso di proprietà imperiale.
ADHS und Mediensucht bei Kindern und Jugendlichen
Authors: Barth Gottfried Maria , Renner Tobias J. 
Published: October 2015

Zusammenfassung. Zielsetzung: Es wird der aktuelle Forschungsstand über den Zusammenhang von ADHS und Mediensucht dargestellt, die beide zu den häufigsten kinder- und jugendpsychiatrischen Störungen gehören. Methodik: Anhand einer systematischen Literaturrecherche wurden aus 190 relevanten Suchergebnissen zum Thema ADHS und Mediensucht bei Kindern und Jugendlichen 125 Artikel zum Download ausgewählt. 57 Veröffentlichungen konnten eingeschlossen werden. Ergebnisse: Es besteht eine klare Evidenz, dass ADHS mit einer hohen Rate an Mediensucht verbunden ist und andererseits bei Mediensucht eine hohe Rate an ADHS-Symptomen gefunden wird. Die meisten Studien belegen nur diese Korrelation ohne Kausalitätsnachweis. Ergebnisse der neurobiologischen Forschung weisen auf die Nähe von ADHS und Mediensucht hin. Schlussfolgerungen: Bei Diagnose einer ADHS muss insbesondere auch die Mediennutzung erfasst werden und bei Vorliegen einer Mediensucht sorgfältig auf ADHS untersucht werden. ADHS muss als Risikofaktor für die Entwicklung einer Mediensucht angesehen werden, adäquate Therapie der ADHS kann dieses Risiko verringern. Eine ausgedehnte Mediennutzung kann Hinweis auf eine ungenügend behandelte ADHS sein.
Häufigkeit und prädiktiver Wert von Early Response in naturalistischen Psychotherapien
Authors: Schlagert Henrike , Hiller Wolfgang 
Published: October 2015

Zusammenfassung. Theoretischer Hintergrund: Verschiedene randomisiert-kontrollierte Studien konnten die Bedeutung frühzeitiger Therapieerfolge für das Therapieergebnis nachweisen. Entsprechende Erkenntnisse unter Routinebedingungen sind bislang selten. Fragestellung: Diese Studie untersucht Häufigkeit, prädiktiven Wert sowie Patientenmerkmale eines frühen Ansprechens auf die Therapie („Early Response“) in einer verhaltenstherapeutischen Hochschulambulanz. Methode: Wir klassifizierten anhand prozentualer Wertereduktion 1109 Patienten verschiedener Störungsgruppen hinsichtlich ihrer psychischen Belastung als Early Responder beziehungsweise Early Nonresponder. Ergebnisse: 48,2 % der Patienten zeigten frühe Therapieerfolge. Early Response erwies sich als Prädiktor für Response (OR = 6,36) und Remission (OR = 3,90). Early Nonresponse sagte eine Verschlechterung der Symptombelastung zu Therapieende vorher (OR = 12,14). Schlussfolgerungen: Frühzeitige Therapieeffekte sind im Routinesetting offenbar von hoher Bedeutung für das Therapieergebnis und sollten bei der Behandlungsplanung stärker berücksichtigt werden.
Room-temperature carbon monoxide oxidation by oxygen over Pt/Al2O3 mediated by reactive platinum carbonates
Authors: Newton Mark A. , Ferri Davide , Smolentsev Grigory , Marchionni Valentina , Nachtegaal Maarten 
Published: October 2015

AbstractRoom-temperature carbon monoxide oxidation, important for maintaining clean air among other applications, is challenging even after a century of research into carbon monoxide oxidation. Here we report using time-resolved diffuse reflectance infrared spectroscopy, X-ray absorption fine structure spectroscopy and mass spectrometry a platinum carbonate-mediated mechanism for the room-temperature oxidation of carbon monoxide. By applying a periodic reduction–oxidation mode of operation we further show that this behaviour is reversible and can be formed into a catalytic cycle that requires molecular communication between metallic platinum nanoparticles and highly dispersed oxidic platinum centres. A new possibility for the attainment of low-temperature oxidation of carbon monoxide is therefore demonstrated.
Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity
Authors: Moniaga Catharina Sagita , Watanabe Sachiko , Honda Tetsuya , Nielsen Søren , Hara-Chikuma Mariko 
Published: October 2015

AbstractAquaporin-9 (AQP9), a water/glycerol channel protein, is expressed in several immune cells including neutrophils; however, its role in immune response remains unknown. Here we show the involvement of AQP9 in hapten-induced contact hypersensitivity (CHS), as a murine model of skin allergic contact dermatitis, using AQP9 knockout (AQP9−/−) mice. First, the CHS response to hapten dinitrofluorobenzene (DNFB) was impaired in AQP9−/− mice compared with wild-type (WT) mice. Adoptive transfer of sensitized AQP9−/− draining lymph node (dLN) cells into WT recipients resulted in a reduced CHS response, indicating impaired sensitization in AQP9−/− mice. Second, administration of WT neutrophils into AQP9−/− mice during sensitization rescued the impaired CHS response. Neutrophil recruitment to dLNs upon hapten application was attenuated by AQP9 deficiency. Coincidentally, AQP9−/− neutrophils showed a reduced CC-chemokine receptor 7 (CCR7) ligand-induced migration efficacy, which was attributed to the attenuated recruitment of neutrophils to dLNs. Furthermore, we found that neutrophil deficiency, observed in AQP9−/− or neutrophil-depleted mice, decreased IL-17A production by dLN cells, which might be responsible for T cell activation during a subsequent CHS response. Taken together, these findings suggest that AQP9 is required for the development of sensitization during cutaneous acquired immune responses via regulating neutrophil function.
A functional module-based exploration between inflammation and cancer in esophagus
Authors: Liu Nannan , Li Chunhua , Huang Yan , Yi Ying , Bo Wanlan , Li Chunmiao , Li Yue , Hu Yongfei , Li Kongning , Wang Hong , Zhuang Liwei , Fan Huihui , Wang Dong 
Published: October 2015

AbstractInflammation contributing to the underlying progression of diverse human cancers has been generally appreciated, however, explorations into the molecular links between inflammation and cancer in esophagus are still at its early stage. In our study, we presented a functional module-based approach, in combination with multiple data resource (gene expression, protein-protein interactions (PPI), transcriptional and post-transcriptional regulations) to decipher the underlying links. Via mapping differentially expressed disease genes, functional disease modules were identified. As indicated, those common genes and interactions tended to play important roles in linking inflammation and cancer. Based on crosstalk analysis, we demonstrated that, although most disease genes were not shared by both kinds of modules, they might act through participating in the same or similar functions to complete the molecular links. Additionally, we applied pivot analysis to extract significant regulators for per significant crosstalk module pair. As shown, pivot regulators might manipulate vital parts of the module subnetworks and then work together to bridge inflammation and cancer in esophagus. Collectively, based on our functional module analysis, we demonstrated that shared genes or interactions, significant crosstalk modules and those significant pivot regulators were served as different functional parts underlying the molecular links between inflammation and cancer in esophagus.
The influence of cancer tissue sampling on the identification of cancer characteristics
Authors: Xu Hui , Guo Xin , Sun Qiang , Zhang Mengmeng , Qi Lishuang , Li Yang , Chen Libin , Gu Yunyan , Guo Zheng , Zhao Wenyuan 
Published: October 2015

AbstractCancer tissue sampling affects the identification of cancer characteristics. We aimed to clarify the source of differentially expressed genes (DEGs) in macro-dissected cancer tissue and develop a robust prognostic signature against the effects of tissue sampling. For estrogen receptor (ER)+ breast cancer patients, we identified DEGs in macro-dissected cancer tissues, malignant epithelial cells and stromal cells, defined as Macro-Dissected-DEGs, Epithelial-DEGs and Stromal-DEGs, respectively. Comparing Epithelial-DEGs to Stromal-DEGs (false discovery rate (FDR) < 10%), 86% of the overlapping genes exhibited consistent dysregulation (defined as Consistent-DEGs) and the other 14% of genes were dysregulated inconsistently (defined as Inconsistent-DEGs). The consistency score of dysregulation directions between Macro-Dissected-DEGs and Consistent-DEGs was 91% (P-value < 2.2 × 10−16, binomial test), whereas the score was only 52% between Macro-Dissected-DEGs and Inconsistent-DEGs (P-value = 0.9, binomial test). Among the gene ontology (GO) terms significantly enriched in Macro-Dissected-DEGs (FDR < 10%), 18 immune-related terms were enriched in Inconsistent-DEGs. DEGs associated with proliferation could reflect common changes of malignant epithelial and stromal cells; DEGs associated with immune functions are sensitive to the percentage of malignant epithelial cells in macro-dissected tissues. A prognostic signature which was insensitive to the cellular composition of macro-dissected tissues was developed and validated for ER+ breast patients.
Utilizing the virus-induced blocking of apoptosis in an easy baculovirus titration method
Authors: Niarchos Athanasios , Lagoumintzis George , Poulas Konstantinos 
Published: October 2015

AbstractBaculovirus-mediated protein expression is a robust experimental technique for producing recombinant higher-eukaryotic proteins because it combines high yields with considerable post-translational modification capabilities. In this expression system, the determination of the titer of recombinant baculovirus stocks is important to achieve the correct multiplicity of infection for effective amplification of the virus and high expression of the target protein. To overcome the drawbacks of existing titration methods (e.g., plaque assay, real-time PCR), we present a simple and reliable assay that uses the ability of baculoviruses to block apoptosis in their host cells to accurately titrate virus samples. Briefly, after incubation with serial dilutions of baculovirus samples, Sf9 cells were UV irradiated and, after apoptosis induction, they were viewed via microscopy; the presence of cluster(s) of infected cells as islets indicated blocked apoptosis. Subsequently, baculovirus titers were calculated through the determination of the 50% endpoint dilution. The method is simple, inexpensive and does not require unique laboratory equipment, consumables or expertise; moreover, it is versatile enough to be adapted for the titration of every virus species that can block apoptosis in any culturable host cells which undergo apoptosis under specific conditions.
Immobilization of gold nanoclusters inside porous electrospun fibers for selective detection of Cu(II): A strategic approach to shielding pristine performance
Authors: Senthamizhan Anitha , Celebioglu Asli , Balusamy Brabu , Uyar Tamer 
Published: October 2015

AbstractHere, a distinct demonstration of highly sensitive and selective detection of copper (Cu2+) in a vastly porous cellulose acetate fibers (pCAF) has been carried out using dithiothreitol capped gold nanocluster (DTT.AuNC) as fluorescent probe. A careful optimization of all potential factors affecting the performance of the probe for effective detection of Cu2+ were studied and the resultant sensor strip exhibiting unique features including high stability, retained parent fluorescence nature and reproducibility. The visual colorimetric detection of Cu2+ in water, presenting the selective sensing performance towards Cu2+ ions over Zn2+, Cd2+ and Hg2+ under UV light in naked eye, contrast to other metal ions that didn’t significantly produce such a change. The comparative sensing performance of DTT.AuNC@pCAF, keeping the nonporous CA fiber (DTT.AuNC@nCAF) as a support matrix has been demonstrated. The resulting weak response of DTT.AuNC@nCAF denotes the lack of ligand protection leading to the poor coordination ability with Cu2+. The determined detection limit (50 ppb) is far lower than the maximum level of Cu2+ in drinking water (1.3 ppm) set by U.S. Environmental Protection Agency (EPA). An interesting find from this study has been the specific oxidation nature between Cu2+ and DTT.AuNC, offering solid evidence for selective sensors.
Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development
Authors: Zhu Yan , Zong Liang , Mei Ling , Zhao Hong-Bo 
Published: October 2015

AbstractOrgan development requires well-established intercellular communication to coordinate cell proliferations and differentiations. MicroRNAs (miRNAs) are small, non-coding RNAs that can broadly regulate gene expression and play a critical role in the organ development. In this study, we found that miRNAs could pass through gap junctions between native cochlear supporting cells to play a role in the cochlear development. Connexin26 (Cx26) and Cx30 are predominant isoforms and co-express in the cochlea. Cx26 deficiency but not Cx30 deficiency can cause cochlear developmental disorders. We found that associated with Cx26 deletion induced the cochlear developmental disorders, deletion of Cx26 but not Cx30 disrupted miRNA intercellular transfer in the cochlea, although inner ear gap junctions still retained permeability after deletion of Cx26. Moreover, we found that deletion of Cx26 but not Cx30 reduced miR-96 expression in the cochlea during postnatal development. The reduction is associated with the cochlear tunnel developmental disorder in Cx26 knockout (KO) mice. These data reveal that Cx26-mediated intercellular communication is required for cochlear development and that deficiency of Cx26 can impair miRNA-mediated intercellular genetic communication in the cochlea, which may lead to cochlear developmental disorders and eventually congenital deafness as previously reported.
Holocentromeres inRhynchosporaare associated with genome-wide centromere-specific repeat arrays interspersed among euchromatin
Authors: Marques André , Ribeiro Tiago , Neumann Pavel , Macas Jiří , Novák Petr , Schubert Veit , Pellino Marco , Fuchs Jörg , Ma Wei , Kuhlmann Markus , Brandt Ronny , Vanzela André L. L. , Beseda Tomáš , Šimková Hana , Pedrosa-Harand Andrea , Houben Andreas 
Published: October 2015

SignificanceHolocentric chromosomes are characterized by kinetochore activity along each sister chromatid. Although the kinetochore structure seems to be well conserved, as in monocentric organisms, the organization of holocentromeres is still elusive, and no centromeric repeat has been found associated with centromeric histone H3 variant-positive centromeric nucleosomes for any holocentric organism studied hitherto. We demonstrate that holocentrics of the sedge (Cyperaceae)Rhynchospora puberapossess different classes of centromere-specific repeats. Holocentromeres are composed of multiple centromeric units interspersing the gene-containing chromatin, and, as a functional adaption, a cell-cycle–dependent shuffling of centromeric units results in the formation of functional (poly)centromeres during cell division. The genome-wide distribution of centromeric repeat arrays interspersing the euchromatin provides a previously unidentified type of centromere organization.
Introduction
Authors: Bernier Mark 
Published: October 2015

AbstractThe first chapter provides an introduction to the central topic of the book, namely, that hope plays a crucial role in Kierkegaard’s narrative: the self is in despair, and faith provides the only means through which we can overcome this condition. Hope, it is suggested, essentially belongs to this narrative. A brief account is given of how Kierkegaard’s pseudonymous authorship will be treated, as well as the organization of the study. First, the nature of the Kierkegaardian self is examined, followed by the condition of despair. This reveals that the nature of despair involves an unwillingness to hope. Next, hope itself is examined, which placed hope as an essential element in the task of the self. Finally, the discussion turns to the relation between hope and faith. Faith, it is seen, involves the willingness to hope, as contrasted with despair’s unwillingness to hope.
Perturbation Methods
Authors: Ruban Anatoly I. 
Published: October 2015

Abstract
Chapter 1 discusses the mathematical aspects of the asymptotic theory. It starts with basic definitions, using for this purpose the so-called coordinate asymptotic expansions. Then the chapter turns to asymptotic analysis of integrals and describe, among others, the method of steepest descent. However, the main attention is with parametric asymptotic expansions. These are used in a wide variety of fluid–dynamic problems, for which purpose a number of asymptotic techniques has been developed. We discuss in Chapter 1 the method of matched asymptotic expansions, the method of multiple scales, the method of strained coordinates, and the WKB method.
Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells
Authors: Kamimura Daisuke , Arima Yasunobu , Tsuruoka Mineko , Jiang Jing-jing , Bando Hidenori , Meng Jie , Sabharwal Lavannya , Stofkova Andrea , Nishikawa Naoki , Higuchi Kotaro , Ogura Hideki , Atsumi Toru , Murakami Masaaki 
Published: October 2015

AbstractKDEL receptor 1 (KDELR1) regulates integrated stress responses (ISR) to promote naive T-cell survival in vivo . In a mouse line having nonfunctional KDELR1, T-Red (naive T-cell reduced) mice, polyclonal naive T cells show excessive ISR and eventually undergo apoptosis. However, breeding T-Red mice with TCR-transgenic mice bearing relatively high TCR affinity rescued the T-Red phenotype, implying a link between ISR-induced apoptosis and TCR-mediated signaling. Here, we showed that strong TCR stimulation reduces ISR in naive T cells. In mice lacking functional KDELR1, surviving naive T cells expressed significantly higher levels of CD5, a surrogate marker of TCR self-reactivity. In addition, higher TCR affinity/avidity was confirmed using a tetramer dissociation assay on the surviving naive T cells, suggesting that among the naive T-cell repertoire, those that receive relatively stronger TCR-mediated signals via self-antigens survive enhanced ISR. Consistent with this observation, weak TCR stimulation with altered peptide ligands decreased the survival and proliferation of naive T cells, whereas stimulation with ligands having higher affinity had no such effect. These results suggest a novel role of TCR-mediated signals in the attenuation of ISR in vivo .
Accelerating the two-point and three-point galaxy correlation functions using Fourier transforms
Authors: Slepian Zachary , Eisenstein Daniel J. 
Published: October 2015

Abstract
Though Fourier transforms (FTs) are a common technique for finding correlation functions, they are not typically used in computations of the anisotropy of the two-point correlation function (2PCF) about the line of sight in wide-angle surveys because the line-of-sight direction is not constant on the Cartesian grid. Here we show how FTs can be used to compute the multipole moments of the anisotropic 2PCF. We also show how FTs can be used to accelerate the 3PCF algorithm of Slepian & Eisenstein. In both cases, these FT methods allow one to avoid the computational cost of pair counting, which scales as the square of the number density of objects in the survey. With the upcoming large data sets of Dark Energy Spectroscopic Instrument, Euclid, and Large Synoptic Survey Telescope, FT techniques will therefore offer an important complement to simple pair or triplet counts.
Recurrent Aeromonas Bacteremia Due to Contaminated Well Water
Authors: Katz Morgan J. , Parrish Nicole M. , Belani Anusha , Shah Maunank 
Published: October 2015

Abstract
Although they are ubiquitous to aquatic environments, Aeromonas species have traditionally been considered nonvirulent; however, in the past 30 years, they have emerged as important human pathogens that can cause a wide spectrum of disease. In this study, we describe a case of recurrent Aeromonas bacteremia in an immunocompetent patient, and this exposure was linked to the patient's home well water supply.