bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens
Authors: Feng Jian , Wilkinson Matthew , Liu Xiaochuan , Purushothaman Immanuel , Ferguson Deveroux , Vialou Vincent , Maze Ian , Shao Ningyi , Kennedy Pamela , Koo JaWook , Dias Caroline , Laitman Benjamin , Stockman Victoria , LaPlant Quincey , Cahill Michael E , Nestler Eric J , Shen Li 
Published: April 2014

Abstract
Background
Increasing evidence supports a role for altered gene expression in mediating the lasting effects of cocaine on the brain, and recent work has demonstrated the involvement of chromatin modifications in these alterations. However, all such studies to date have been restricted by their reliance on microarray technologies that have intrinsic limitations.

Results
We use next generation sequencing methods, RNA-seq and ChIP-seq for RNA polymerase II and several histone methylation marks, to obtain a more complete view of cocaine-induced changes in gene expression and associated adaptations in numerous modes of chromatin regulation in the mouse nucleus accumbens, a key brain reward region. We demonstrate an unexpectedly large number of pre-mRNA splicing alterations in response to repeated cocaine treatment. In addition, we identify combinations of chromatin changes, or signatures, that correlate with cocaine-dependent regulation of gene expression, including those involving pre-mRNA alternative splicing. Through bioinformatic prediction and biological validation, we identify one particular splicing factor, A2BP1(Rbfox1/Fox-1), which is enriched at genes that display certain chromatin signatures and contributes to drug-induced behavioral abnormalities. Together, this delineation of the cocaine-induced epigenome in the nucleus accumbens reveals several novel modes of regulation by which cocaine alters the brain.

Conclusions
We establish combinatorial chromatin and transcriptional profiles in mouse nucleus accumbens after repeated cocaine treatment. These results serve as an important resource for the field and provide a template for the analysis of other systems to reveal new transcriptional and epigenetic mechanisms of neuronal regulation.
Treatment of High-Risk Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia in Adolescents and Adults According to Early Cytologic Response and Minimal Residual Disease After Consolidation Assessed by Flow Cytometry: Final Results of the PETHEMA ALL-AR-03 Trial
Authors: Ribera Josep-Maria , Oriol Albert , Morgades Mireia , Montesinos Pau , Sarrà Josep , González-Campos José , Brunet Salut , Tormo Mar , Fernández-Abellán Pascual , Guàrdia Ramon , Bernal María-Teresa , Esteve Jordi , Barba Pere , Moreno María-José , Bermúdez Arancha , Cladera Antonia , Escoda Lourdes , García-Boyero Raimundo , del Potro Eloy , Bergua Juan , Amigo María-Luz , Grande Carlos , Rabuñal María-José , Hernández-Rivas Jesús-María , Feliu Evarist 
Published: April 2014

PurposeMinimal residual disease (MRD) is an important prognostic factor in adults with acute lymphoblastic leukemia (ALL) and may be used for treatment decisions. The Programa Español de Tratamientos en Hematología (PETHEMA) ALL-AR-03 trial (Treatment of High Risk Adult Acute Lymphoblastic Leukemia [LAL-AR/2003]) assigned adolescent and adult patients (age 15 to 60 years) with high-risk ALL (HR-ALL) without the Philadelphia (Ph) chromosome to chemotherapy or to allogeneic hematopoietic stem-cell transplantation (allo-HSCT) according to early cytologic response (day 14) and flow-MRD level after consolidation.Patients and MethodsPatients with good early cytologic response (< 10% blasts in bone marrow at day 14 of induction) and a flow-MRD level less than 5 × 10−4at the end of consolidation were assigned to delayed consolidation and maintenance therapy, and allo-HSCT was scheduled in patients with poor early cytologic response or flow-MRD level ≥ 5 × 10−4.ResultsComplete remission was attained in 282 (87%) of 326 patients, and 179 (76%) of 236 patients who completed early consolidation were assigned by intention-to treat to receive allo-HSCT (71) or chemotherapy (108). Five-year disease-free survival (DFS) and overall survival (OS) probabilities were 37% and 35% for the whole series, 32% and 37% for patients assigned to allo-HSCT, and 55% and 59% for those assigned to chemotherapy. Multivariable analysis showed poor MRD clearance (≥ 1 × 10−3after induction and ≥ 5 × 10−4after early consolidation) as the only prognostic factor for DFS and OS.ConclusionPrognosis for Ph-negative HR-ALL in adolescents and adults with good early response to induction and low flow-MRD levels after consolidation is quite favorable when allo-HSCT is avoided. In this study, the pattern of MRD clearance was the only prognostic factor for DFS and OS.
Dynamic Helicity Control of a Single-helical Oligooxime Complex and Acid–Base-triggered Repeated Helicity Inversion Mediated by Amino Acids
Authors: Sairenji Shiho , Akine Shigehisa , Nabeshima Tatsuya 
Published: April 2014

Abstract
Helicity of a single-helical oligooxime complex [(L)Zn3La]3+ was controlled efficiently by coordination with various kinds of α-amino acids. The helicity depends on the residues of the amino acids. A mixture of [(L)Zn3La]3+ and cysteic acid underwent helicity inversion repeatedly by the alternate addition of an acid and a base.
Understanding Barriers to Competitive Employment: A Family Perspective
Authors: Francis Grace L. , Gross Judith M. S. , Turnbull Ann P. , Turnbull Rud 
Published: April 2014

AbstractThis study reports the results of a survey and interviews with families who attended Family Employment Awareness Training (FEAT), a training designed to increase expectations for competitive employment and knowledge about employment resources among families who have members with disabilities, to determine their perceptions of barriers to competitive employment for people with individualized support needs (ISN). Analysis of survey and interview data identified barriers related to (a) characteristics of people with ISN, (b) agencies and programs, (c) families, (d) expectations, (e) employers, and (f) the economy. This study uses an ecological framework (Bronfenbrenner, 1979, 1986) to organize the findings. We also discuss implications for practice and policy, including recommendations for improving education and support for people with ISN, families, and professionals in the micro-, exo-, and macrosystems.
Test of Self-Determination Theory in Swimmers With and Without Down Syndrome
Authors: Casey Amanda Faith , Wang Xu , Boucher Jacques 
Published: April 2014

Abstract
Self-determination theory (SDT) may offer insight into the motives behind sport participation by individuals with Down syndrome (DS). The Pictorial Motivation Scale (PMS), developed by Poulin (1992), evaluated the motivation of junior athletes with (n = 15) and without DS (n = 15) participating in inclusive community-based swimming. In line with SDT, cluster analyses showed that intrinsic motivation, extrinsic motivation, and amotivation were all present in athletes with and without disabilities. Swimmers with DS scored significantly higher in intrinsic motivation than non–self-determined extrinsic motivation (−0.45, p &lt; 0.001) and amotivation (−1.28, p &lt; 0.001), suggesting involvement in community-based inclusive sport may promote enhanced psychological functioning in this sample. Further research may be warranted into the motivation of athletes with DS across longer periods of time.
Advertising and climate change, relationships and divergences
Authors: Jurado Deborah González , Maldonado Carmen Jambrino 
Published: April 2014

Abstract
The aim of this article is to analyse the sense and evolution of advertising communication strategies since the phenomenon of climate change appeared and started to be projected by the media, which simultaneously sparked off the public opinion debate. Several publications are examined so as to understand how environmentalist keys about publicity are reflected in scientific literature. The article pays particular attention to how the business perspective becomes a social and communication agent.
From the rhetoric of science to scientific journalism
Authors: Gross Teodoro León 
Published: April 2014

Abstract
Journalism and science are forced into unavoidable coexistence, despite the mistrust that the scientific sphere has shown towards journalism, related to its historical wariness towards rhetoric. In fact, scientific discontent is not unfounded, faced with scarcely specialized coverage, secondary sources, rudimentary texts and genders, agenda marginalization, etc. However, other misgivings are the result of misunderstanding journalism, for which the pedagogical function is subsidiary to the informative function. Journalism is not a platform for scientific debate, but an activity that has its own logic, language and hierarchical criteria. Cooperation is, above all, necessary – journalism adds to the social value of scientific activity, it contributes visibility and even attracts resources – and collaboration is advisable in order to stimulate a more competent scientific journalism.
Media and climate change: From content analysis to analysis content. The interdisciplinary construction of a new paradigm
Authors: Nosty Bernardo Díaz 
Published: April 2014

Abstract
In order to analyse the relationship between communication and climate change and the problems involved in transmitting the scientific consensus to public opinion by means of the media, the researcher must undertake a special commitment beyond the presupposed ethical stance. The transcendence of the matter under study exceeds the scope of the routine of scholarly works and demands the deployment of interdisciplinary cooperation. That is, developing a proactive strategy which is useful for the public, that can participate in scientific actions aimed at mitigating the effects of global warming, and can cooperate in correcting its causes. There is also a theoretical hypothesis, the inability of the media, as the expression of a system in crisis, to clearly explain the real causes of the phenomenon and point out solutions, as well as the need to construct a new paradigm, prior to or as a consequence of a social contract of sustainability.
No more great expectations: Media response to Obama’s climate action plan
Authors: Hoyos Gloria 
Published: April 2014

Abstract
On 25 June 2013 the President of the United States of America, Barack Obama announced the Climate Action Plan, a package of measures intended to slow the effects of climate change. If the political consequences of this speech are yet unknown, the media response to Obama’s announcement serves as a good example of how media covers news related to climate change. This article approaches the immediate response that the most important media in the United States had to Obama’s announcement and how climate change is a complex issue that needs to be responsibly addressed by the scientific community, politicians and journalists.
Hemostatic Abnormalities in Noonan Syndrome
Authors: Artoni Andrea , Selicorni Angelo , Passamonti Serena M. , Lecchi Anna , Bucciarelli Paolo , Cerutti Marta , Cianci Paola , Gianniello Francesca , Martinelli Ida 
Published: April 2014

BACKGROUND:
A bleeding diathesis is a common feature of Noonan syndrome, and various coagulation abnormalities have been reported. Platelet function has never been carefully investigated.

METHODS:
The degree of bleeding diathesis in a cohort of patients with Noonan syndrome was evaluated by a validated bleeding score and investigated with coagulation and platelet function tests. If ratios of prothrombin time and/or activated partial thromboplastin time were prolonged, the activity of clotting factors was measured. Individuals with no history of bleeding formed the control group.

RESULTS:
The study population included 39 patients and 28 controls. Bleeding score was ≥2 (ie, suggestive of a moderate bleeding diathesis) in 15 patients (38.5%) and ≥4 (ie, suggestive of a severe bleeding diathesis) in 7 (17.9%). Abnormal coagulation and/or platelet function tests were found in 14 patients with bleeding score ≥2 (93.3%) but also in 21 (87.5%) of those with bleeding score &lt;2. The prothrombin time and activated partial thromboplastin time were prolonged in 18 patients (46%) and partial deficiency of factor VII, alone or in combination with the deficiency of other vitamin K–dependent factors, was the most frequent coagulation abnormality. Moreover, platelet aggregation and secretion were reduced in 29 of 35 patients (82.9%, P &lt; .01 for all aggregating agents).

CONCLUSIONS:
Nearly 40% of patients with the Noonan syndrome had a bleeding diathesis and &gt;90% of them had platelet function and/or coagulation abnormalities. Results of these tests should be taken into account in the management of bleeding or invasive procedures in these patients.
Language Problems in Children With ADHD: A Community-Based Study
Authors: Sciberras Emma , Mueller Kathryn L. , Efron Daryl , Bisset Matthew , Anderson Vicki , Schilpzand Elizabeth J. , Jongeling Brad , Nicholson Jan M. 
Published: April 2014

OBJECTIVES:
To examine the prevalence of language problems in children with attention-deficit/hyperactivity disorder (ADHD) versus non-ADHD controls, and the impact of language problems on the social and academic functioning of children with ADHD.

METHODS:
Children (6 to 8 years) with ADHD (n = 179) and controls (n = 212) were recruited through 43 Melbourne schools. ADHD was assessed by using the Conners 3 ADHD Index and the Diagnostic Interview Schedule for Children IV. Oral language was assessed by using the Clinical Evaluation of Language Fundamentals, fourth edition, screener. Academic functioning was measured via direct assessment (Wide Range Achievement Test 4) and teacher report (Social Skills Improvement System). Social functioning was measured via parent and teacher report (Strengths and Difficulties Questionnaire; Social Skills Improvement System). Logistic and linear regression models were adjusted for sociodemographic factors and child comorbidities.

RESULTS:
Children with ADHD had a higher prevalence of language problems than controls after adjustment for sociodemographic factors and comorbidities (odds ratio, 2.8; 95% confidence interval [CI], 1.5 to 5.1). Compared with children with ADHD alone, those with language problems had poorer word reading (mean difference [MD], −11.6; 95% CI, −16.4 to −6.9; effect size, −0.7), math computation (MD, −11.4; 95% CI, −15.0 to −7.7; effect size, −0.8), and academic competence (MD, −10.1; 95% CI, −14.0 to −6.1; effect size, −0.7). Language problems were not associated with poorer social functioning.

CONCLUSIONS:
Children with ADHD had a higher prevalence of language problems than controls, and language problems in children with ADHD contributed to markedly poorer academic functioning.
Anxiety in Children With Attention-Deficit/Hyperactivity Disorder
Authors: Sciberras Emma , Lycett Kate , Efron Daryl , Mensah Fiona , Gerner Bibi , Hiscock Harriet 
Published: April 2014

OBJECTIVES:
Although anxiety is common in children with attention-deficit/hyperactivity disorder (ADHD), it is unclear how anxiety influences the lives of these children. This study examined the association between anxiety comorbidities and functioning by comparing children with ADHD and no, 1, or ≥2 anxiety comorbidities. Differential associations were examined by current ADHD presentation (subtype).

METHODS:
Children with diagnostically confirmed ADHD (N = 392; 5–13 years) were recruited via 21 pediatrician practices across Victoria, Australia. Anxiety was assessed by using the Anxiety Disorders Interview Schedule for Children—IV. Functional measures included parent-reported: quality of life (QoL; Pediatric Quality of Life Inventory 4.0), behavior and peer problems (Strengths and Difficulties Questionnaire), daily functioning (Daily Parent Rating of Evening and Morning Behavior), and school attendance. Teacher-reported behavior and peer problems (Strengths and Difficulties Questionnaire) were also examined. Linear and logistic regression controlled for ADHD severity, medication use, comorbidities, and demographic factors.

RESULTS:
Children with ≥2 anxiety comorbidities (n = 143; 39%) had poorer QoL (effect size: –0.8) and more difficulties with behavior (effect size: 0.4) and daily functioning (effect size: 0.3) than children without anxiety (n = 132; 36%). Poorer functioning was not observed for children with 1 anxiety comorbidity (n = 95; 26%). Two or more anxiety comorbidities were associated with poorer functioning for children with both ADHD-Inattentive and ADHD-Combined presentation.

CONCLUSIONS:
Children with ADHD demonstrate poorer QoL, daily functioning and behavior when ≥2 anxiety comorbidities are present. Future research should examine whether treating anxiety in children with ADHD improves functional outcomes.
Effects of Mechanical Strain on Amorphous Silicon Thin-Film Transistors
Authors: Gleskova H. , Wagner S. , Soboyejo W. , Suo Z. 
Published: April 2014

AbstractWe evaluated a-Si:H TFTs fabricated on polyimide foil under uniaxial compressive or tensile strain. The strain was induced by bending or stretching. All experiments confirmed that the on-current and hence the electron linear mobility depend on strain å as μ = μ0 (1 + 26·ε), where tensile strain has a positive sign. Upon the application of stress the mobility changes instantly and then remains unchanged in measurements up to 40 hours. In the majority of the TFTs the off-current and leakage current do not change. In tension, the TFTs fail mechanically at a strain of ∼ 3x10-2 but recover if the strain is released ‘immediately’.
Investigating Habitat use, Prey Consumption, and Dispersal Response as Potential Coexistence Mechanisms using Morphologically Similar Species of Predaceous Diving Beetles (Coleoptera: Dytiscidae)
Authors: Pitcher K A , Yee D A 
Published: April 2014

AbstractDifferences in habitat use and dispersal responses among competing species are mechanisms that may influence patterns of coexistence. Predaceous diving beetles (Coleoptera: Dytiscidae) are a model group for testing these potential coexistence mechanisms because they are abundant, interact in finite habitats, and are mobile among habitats. We focused on two morphologically similar species, Laccophilus fasciatus rufus (Aubé) and Laccophilus proximus (Say), to determine if mechanisms exist that help to explain patterns of their coexistence. Behavioral observations and feeding trials in the laboratory, a field experiment, and a mesocosm experiment were used to determine if habitat use, prey consumption, or dispersal rates of these two species were inherently different or changed when in the presence of intra- or interspecific competitors. We found no difference between habitat use or prey consumption between species in constant depth aquaria, and no effect of intra- or interspecifics on their behaviors. In variable depth aquaria, L. proximus occupied significantly shallower habitat when compared with L. ƒ. rufus; in the former this difference only occurred between conspecific treatments. Field collections confirmed that L. proximus occupied shallower habitats than L. f. rufus. In field mesocosms, L. proximus displayed higher dispersal rates than L. ƒ. rufus. These species also do not appear food limited in the field, suggesting that adult competition for food is unlikely. L.f. rufus and L. proximus exhibit different habitat use and dispersal responses, but this does not seem to be in response to intra- or interspecific competitive interactions.
Suicide Among Young Alaska Native Men: Community Risk Factors and Alcohol Control
Authors: Berman Matthew 
Published: April 2014

Objectives. I examined community risk factors that explained variation in suicide rates among young rural Alaska Native men, evaluating the effectiveness of local alcohol control as a public health policy to reduce this population’s historically high vulnerability. Methods. I compiled suicide data, alcohol control status, and community-level social, cultural, and economic characteristics for Alaska Native men aged 15 to 34 years in 178 small Alaska communities from 1980 to 2007. Poisson regression equations explained variation in suicide rates as a function of endogenous alcohol control and community characteristics. Results. Suicide rates were higher in communities prohibiting alcohol importation under state law, but the effect was not significant after controlling for other community characteristics. More remote communities, those with fewer non-Natives, and those with evidence of cultural divides had higher suicide risks. Communities with higher incomes, more married couples, and traditional elders had lower risks. Conclusions. Alcohol control is ineffective in preventing suicide among Alaska Natives; suicide instead appears related to particular complex community characteristics that are either protective or increase risk. Communities have limited means to pursue economic and cultural development strategies that might offer more protection.
American Indian and Alaska Native Infant and Pediatric Mortality, United States, 1999–2009
Authors: Wong Charlene A. , Gachupin Francine C. , Holman Robert C. , MacDorman Marian F. , Cheek James E. , Holve Steve , Singleton Rosalyn J. 
Published: April 2014

Objectives. We described American Indian/Alaska Native (AI/AN) infant and pediatric death rates and leading causes of death. Methods. We adjusted National Vital Statistics System mortality data for AI/AN racial misclassification by linkage with Indian Health Service (IHS) registration records. We determined average annual death rates and leading causes of death for 1999 to 2009 for AI/AN versus White infants and children. We limited the analysis to IHS Contract Health Service Delivery Area counties. Results. The AI/AN infant death rate was 914 (rate ratio [RR] = 1.61; 95% confidence interval [CI] = 1.55, 1.67). Sudden infant death syndrome, unintentional injuries, and influenza or pneumonia were more common in AI/AN versus White infants. The overall AI/AN pediatric death rates were 69.6 for ages 1 to 4 years (RR = 2.56; 95% CI = 2.38, 2.75), 28.9 for ages 5 to 9 years (RR = 2.12; 95% CI = 1.92, 2.34), 37.3 for ages 10 to 14 years (RR = 2.22; 95% CI = 2.04, 2.40), and 158.4 for ages 15 to 19 years (RR = 2.71; 95% CI = 2.60, 2.82). Unintentional injuries and suicide occurred at higher rates among AI/AN youths versus White youths. Conclusions. Death rates for AI/AN infants and children were higher than for Whites, with regional disparities. Several leading causes of death in the AI/AN pediatric population are potentially preventable.
Kidney Cancer Incidence and Mortality Among American Indians and Alaska Natives in the United States, 1990–2009
Authors: Li Jun , Weir Hannah K. , Jim Melissa A. , King Sallyann M. , Wilson Reda , Master Viraj A. 
Published: April 2014

Objectives. We describe rates and trends in kidney cancer incidence and mortality and identify disparities between American Indian/Alaska Native (AI/AN) and White populations. Methods. To improve identification of AI/AN race, incidence and mortality data were linked with Indian Health Service (IHS) patient records. Analysis focused on residents of IHS Contract Health Service Delivery Area counties; Hispanics were excluded. We calculated age-adjusted kidney cancer incidence (2001–2009) and death rates (1990–2009) by sex, age, and IHS region. Results. AI/AN persons have a 1.6 times higher kidney cancer incidence and a 1.9 times higher kidney cancer death rate than Whites. Despite a significant decline in kidney cancer death rates for Whites (annual percentage change [APC] = −0.3; 95% confidence interval [CI] = −0.5, 0.0), death rates for AI/AN persons remained stable (APC = 0.4; 95% CI = −0.7, 1.5). Kidney cancer incidence rates rose more rapidly for AI/AN persons (APC = 3.5; 95% CI = 1.2, 5.8) than for Whites (APC = 2.1; 95% CI = 1.4, 2.8). Conclusions. AI/AN individuals have greater risk of developing and dying of kidney cancers. Incidence rates have increased faster in AI/AN populations than in Whites. Death rates have decreased slightly in Whites but remained stable in AI/AN populations. Racial disparities in kidney cancer are widening.