bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of A G‐Quadruplex Unwinder That Unleashes the Translation of G‐Quadruplex‐Containing mRNA without Inducing DNA Damage
Authors: Teng Xucong , Hu Difei , Dai Yicong , Jing Haitao , Hu Wenxuan , Zhang Qiushuang , Zhang Na , Li Jinghong 
Published: July 2024

AbstractTo explore the mechanisms and therapeutic strategies for G‐quadruplex (G4) mediated diseases, it is crucial to manipulate and intervene in intracellular G4 structures using small molecular tools. While hundreds of G4 stabilizers have been developed, there is a significant gap in the availability of G4 unwinding agents. Here, we propose a strategy to disrupt G‐quadruplexes by forming G−C hydrogen bonds with chemically modified cytidine trimers. We validated a good G4 unwinder, the 2′‐F cytidine trimer (2′‐F C3). 2′‐F C3 does not inhibit cell growth nor cause severe DNA damage at a concentration below 10 μM. Moreover, 2′‐F C3 does not affect gene transcription nor RNA splicing, while it significantly enhances the translation of G4‐containing mRNA and upregulates RNA splicing, RNA processing and cell cycle pathways. The discovery of this G4 unwinder provides a functional tool for the chemical modulation of G4s in living cells.
Exhaled Anesthetic Xenon Regeneration by Gas Separation Using a Metal–Organic Framework with Sorbent‐Sorbate Induced‐Fit
Authors: Zhao Li , Peng Xiaowan , Deng Chenghua , Li Jia‐Han , Pan Huiyuan , Zou Jin‐Sheng , Liu Bei , Deng Chun , Xiao Peng , Sun Changyu , Peng Yun‐Lei , Chen Guangjin , Zaworotko Michael J. 
Published: July 2024

AbstractNoble gas xenon (Xe) is an excellent anesthetic gas, but its rarity, high cost and constrained production prohibits wide use in medicine. Here, we have developed a closed‐circuit anesthetic Xe recovery and reusage process with highly effective CO2‐specific adsorbent CUPMOF‐5 that is promising to solve the anesthetic Xe supply problem. CUPMOF‐5 possesses spacious cage cavities interconnected in four directions by confinement throat apertures of ~3.4 Å, which makes it an ideal molecular sieving of CO2 from Xe, O2, N2 with the benchmark selectivity and high uptake capacity of CO2. In situ single‐crystal X‐ray diffraction (SCXRD) and computational simulation solidly revealed the vital sieving role of the confined throat and the sorbent‐sorbate induced‐fit strengthening binding interaction to CO2. CUPMOF‐5 can remove 5 % CO2 even from actual moist exhaled anesthetic gases, and achieves the highest Xe recovery rate (99.8 %) so far, as verified by breakthrough experiments. This endows CUPMOF‐5 great potential for the on‐line CO2 removal and Xe recovery from anesthetic closed‐circuits.
Top management team gender diversity and green innovation: A contingent curvilinear link
Authors: Liu Xilu , Liao Yi‐Chuan , Ma Pengcheng , Dong Yusen 
Published: July 2024

AbstractThe increasing significance of green innovation for firm competitiveness introduces greater risks and uncertain returns, challenging top managers' strategic decisions. The influence of top management team (TMT) characteristics, particularly gender diversity, on green innovation remains unclear. Drawing on gender difference and social identity theories, this study examines the curvilinear relationship between TMT gender diversity and green innovation among 2026 Chinese publicly listed manufacturing firms from 2011 to 2018. Through the use of fixed‐effects Poisson models to confirm our hypotheses, we uncover an inverted U‐shaped relationship between TMT gender diversity and green innovation. Furthermore, we delve into the contingent roles of individual, corporate, and industry factors affecting this primary relationship. Specifically, our findings reveal that the educational attainment of female executives and the strength of green industry innovation flatten the inverted U‐shaped curve between TMT gender diversity and green innovation, whereas state ownership steepen it. Our study resolves the inconsistencies found in previous research by integrating multiple theoretical perspectives and offers empirical insights into the role of women in shaping sustainable development in emerging markets.
Collective victim beliefs in the aftermath of historical trauma and their effects on psychological well‐being: Initial findings among the Polish diaspora in the United States
Authors: Skrodzka Magdalena , Vollhardt Johanna Ray 
Published: July 2024

AbstractHistorical trauma impacts the affected groups long after traumatic events. In response to such experiences, people may make sense of this history through collective victimisation beliefs that compare their ingroup's experiences to outgroups' experiences. Additionally, they may perceive these collective experiences as central to their self and group identity, or distance themselves from them. However, it is not yet well understood how distinct beliefs about historical trauma are linked to psychological well‐being. The present study examined this question among the Polish diaspora in the United States (N = 280). Mediation analyses showed a negative indirect effect of exclusive victim beliefs and centrality of collective victimisation on psychological well‐being, while inclusive victim beliefs and decentring collective victimisation had positive indirect effects on psychological well‐being. Structural equation modelling examining all collective victim beliefs simultaneously highlighted historical victimisation as identity content (a subscale of centrality of collective victimisation) as a particularly important predictor of psychological well‐being, through historical trauma emotions. Overall, in line with appraisal theory, these findings suggest that how a group's historical victimisation is construed is linked to emotional processes and can predict psychological well‐being. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Long‐Life Pillar[5]quinone Cathode for Aqueous Zinc‐Ion Batteries
Authors: Yeşilot Serkan , Solmaz Yasemin , Kılıç Nazmiye , Unal Burcu , Sel Ozlem , Demir‐Cakan Rezan 
Published: July 2024

AbstractAqueous zinc ion batteries (ZIBs) are currently gaining a significant amount of attention as a low‐cost and high safety energy storage option. While mostly inorganic structures are used as cathode materials in aqueous zinc batteries, these materials undergo structural degradation, therefore, alternative organic cathodes are expected to be developed to replace inorganic materials in aqueous zinc ion batteries (AZIBs). In this work, pillar[5]quinone (P5Q) is used as a cathode in AZIBs for the first time. Besides investigating the charge storage mechanism and interfacial property evolution of P5Q by various ex situ analyses, electrochemical quartz crystal microbalance (EQCM) and density functional theory (DFT) demonstrates both Zn2+ and H+ incorporation. The P5Q exhibits >99 % Coulombic efficiency through 10000 cycles at ultra‐fast (500 °C) current density, yielding a capacity value of approximately 120 mAh g−1 at the end of the cycle. When the current density is changed from 500 °C to 120 °C, an initial discharge capacity of approximately 182 mAh g−1 is achieved, demonstrating outstanding performance with over 80 % capacity retention for the subsequent 7000 cycles.
Multi‐graph representation spatio‐temporal attention networks for traffic forecasting in the cinematic metaverse
Authors: Li Ke , He Xiaoming , Liu Yinqiu , Chen Meng 
Published: July 2024

AbstractThe cinematic metaverse aims to create a virtual space with the context of a film. Users can enter this space in the form of avatars, experiencing the cinematic plot firsthand in an immersive manner. This requires us to design a rational computation resource allocation and synchronization algorithm to meet the demands of multi‐objective joint optimization, such as low latency and high throughput, which ensures that users can seamlessly switch between virtual and real worlds and acquire immersive experiences. Unfortunately, the explosive growth in the number of users makes it difficult to jointly optimize multiple objectives. Predicting traffic generated by the users' avatars in the cinematic metaverse is significant for the optimization process. Although graph neural networks‐based traffic prediction models achieve superior prediction accuracy, these methods rely only on physical distances‐based topological graph information, while failing to comprehensively reflect the real relationships between avatars in the cinematic metaverse. To address this issue, we present a novel Multi‐Graph Representation Spatio‐Temporal Attention Networks (MGRSTANet) for traffic prediction in the cinematic metaverse. Specifically, based on multiple topological graph information (e.g., physical distances, centerity, and similarity), we first design Multi‐Graph Embedding (MGE) module to generate multiple graph representations, thus reflecting on the real relationships between avatars more comprehensively. The Spatio‐Temporal Attention (STAtt) module is then proposed to extract spatio‐temporal correlations in each graph representations, thus improving prediction accuracy. We conduct simulation experiments to evaluate the effectiveness of MGRSTANet. The experimental results demonstrate that our proposed model outperforms the state‐of‐the‐art baselines in terms of prediction accuracy, making it appropriate for traffic forecasting in the cinematic metaverse.
神経性食思不振症による心停止に対しV–A ECMOを使用した1例〜栄養障害による痩せへの蘇生とその注意点〜(Use of veno–arterial extracorporeal membrane oxygenation in cardiac arrest due to anorexia nervosa: A case report – Notes on resuscitations –)
Authors: 剛 鈴木 , 泰彦 塚田 , 憲 伊関 
Published: July 2024

要旨神経性食思不振症は精神科領域で取り扱う疾患のなかで最も死亡率が高い。症例：16歳女性。体重26kg，BMI 11.5kg/m2と高度な痩せのため入院となった。入院3日目に心停止状態で発見された。血糖は7mg/dLと低く心停止の原因と考えられた。心肺蘇生および糖補充により心拍が再開したが，非持続性の心室頻拍を示し循環動態が不安定であった。経胸壁心臓超音波検査はtakotsubo cardiomyopathyを疑う所見を示し，血糖補正後のrefeeding syndromeまたは蘇生後の影響と考えられた。その後，再び心停止となったが蘇生に反応せずV–A ECMOが導入された。その後状態は安定し第6病日にV–A ECMOを離脱，第43病日に人工呼吸器を離脱した。第50病日にICUを退室，第56病日に心身医療科へ転棟した。神経性食思不振症による心停止に対してV–A ECMOを用いた蘇生の報告は少ない。神経性食思不振症では栄養障害から血管発達が阻害されている可能性があり，V–A ECMOのカニューラ選択には注意を要する。
Gray matter alterations in Huntington's disease: A meta‐analysis of VBM neuroimaging studies
Authors: Wang Xi , Li Yuming , Li Boyi , Shang Huifang , Yang Jing 
Published: July 2024

AbstractIncreasing neuroimaging studies have attempted to identify biomarkers of Huntington's disease (HD) progression. Here, we conducted voxel‐based meta‐analyses of voxel‐based morphometry (VBM) studies on HD to investigate the evolution of gray matter volume (GMV) alterations and explore the effects of genetic and clinical features on GMV changes. A systematic review was performed to identify the relevant studies. Meta‐analyses of whole‐brain VBM studies were performed to assess the regional GMV changes in all HD mutation carriers, in presymptomatic HD (pre‐HD), and in symptomatic HD (sym‐HD). A quantitative comparison was performed between pre‐HD and sym‐HD. Meta‐regression analyses were used to explore the effects of genetic and clinical features on GMV changes. Twenty‐eight studies were included, comparing a total of 1811 HD mutation carriers [including 1150 pre‐HD and 560 sym‐HD] and 969 healthy controls (HCs). Pre‐HD showed decreased GMV in the bilateral caudate nuclei, putamen, insula, anterior cingulate/paracingulate gyri, middle temporal gyri, and left dorsolateral superior frontal gyrus compared with HCs. Compared with pre‐HD, GMV decrease in sym‐HD extended to the bilateral median cingulate/paracingulate gyri, Rolandic operculum and middle occipital gyri, left amygdala, and superior temporal gyrus. Meta‐regression analyses found that age, mean lengths of CAG repeats, and disease burden were negatively associated with GMV atrophy of the bilateral caudate and right insula in all HD mutation carriers. This meta‐analysis revealed the pattern of GMV changes from pre‐HD to sym‐HD, prompting the understanding of HD progression. The pattern of GMV changes may be biomarkers for disease progression in HD.
Autologous bone grafting in combination with autologous chondrocyte implantation yields favourable outcomes in the treatment of osteochondral defects of the knee: A systematic literature review
Authors: Oehme Stephan , Burger Joost A. , Krafzick Sophie , Bartek Benjamin , Winkler Tobias , Jung Tobias 
Published: July 2024

AbstractPurposeThis study addresses the gap in the current literature by evaluating the combined treatment of autologous bone grafting and autologous chondrocyte implantation (ABCI) for osteochondral defects of the knee. It aims to evaluate clinical outcomes against methodological quality and to summarize histological results and surgical techniques.MethodsA thorough search was conducted across Pubmed, Cochrane and Embase databases. Studies reporting clinical outcomes of ABCI for osteochondral defects of the knee were included. Patient‐reported outcome measures (PROMs), failure rates, methodological quality and potential conflicts of interest were evaluated. Histological results and surgical techniques were summarized.ResultsEighteen studies with 344 analyzed patients met the eligibility criteria for inclusion. All studies showed a significant improvement (p < 0.05) across different PROMs (subjective International Knee Documentation Committee score, Cincinnati Knee Rating System, Visual Analogue Scale, Lysholm Score, Tegner Activity Scale, Knee injury and Osteoarthritis Outcome Score and Knee Society Score) compared to the preoperative status. Failure rates ranged from 0% to 17.6%, with a mean follow‐up of 73.2 months (range: 9.0–143.6 months). Methodological quality was low to medium, including only one comparative study. Six studies reviewed reported a potential conflict of interest. The histological assessment showed effective bonding between autologous chondrocytes and bone graft. A large degree of variability was observed in the operative technique used.ConclusionThe current literature suggests that ABCI yields good clinical outcomes at mid‐ to long‐term follow‐up with favourable histological results for osteochondral defects of the knee. However, future research should focus on high‐quality comparative studies to better guide treatment choices. Introducing ABCI as the standard abbreviation may enhance clarity in future research.Level of EvidenceLevel IV.
Quantitative Hochdurchsatzanalyse von Schlüsselgeruchstoffen in Lebensmitteln mittels UHPLC‐MS/MS
Authors: Bösl Markus , Hofmann Thomas F. 
Published: July 2024

AbstractDie Analyse von Aromastoffen mittels Flüssigchromatographie (LC) anstelle der Gaschromatographie (GC) ermöglicht die simultane Analyse von Aromastoffen und Geschmacksstoffen auf einer einzigen Analyseplattform. Durch die schnelle Probenvorbereitung und kurzen Messzeiten können Proben dabei im Hochdurchsatz analysiert werden. Wegen der hohen Flüchtigkeit und schlechten Ionisierbarkeit bei der „Electrospray Ionization” (ESI) werden die Aromastoffe vor der Analyse mittels Flüssigchromatographie‐Tandem‐Massenspektrometrie (LC‐MS/MS) einer Derivatisierung unterzogen. Für die Analyse von Aromastoffen mit einer Carbonylgruppe konnte dabei die Derivatisierung mit 3‐Nitrophenylhydrazin (3NPH) etabliert werden.Der Ansatz der simultanen Quantifizierung von Aroma‐ und Geschmacksstoffen bzw. die Analyse von Aromastoffen mittels LC‐MS/MS im Allgemeinen konnte bisher nur auf eine kleine Auswahl von Lebensmitteln und Analyten angewandt werden. Das Ziel dieser Studie war es deshalb, die breite Anwendbarkeit der Methode von Aromastoff‐Analytik mittels LC‐MS zu belegen. Dazu wurde eine schnelle Hochdurchsatzmethode für die Quantifizierung der in Lebensmitteln am häufigsten vorkommenden Aromastoffen, den sogenannten Generalisten, entwickelt.Da die Gruppe der Generalisten sowohl Alkohole als auch Thiole enthält, die sich nicht mit 3NPH umsetzen lassen, wurde eine neue Derivatisierungsmethode entwickelt. Daher wurde Dimethyl‐tolyl‐glycidyl ammonium (DGTA) synthetisiert, welches eine reaktive Epoxidgruppe, sowie eine ähnliche Polarität wie 3NPH und eine gute Ionisierbarkeit bei der ESI aufwies. Nach Optimierung der Derivatisierungsparameter wurde eine effiziente Methode zur Analyse flüchtiger Alkohole, Phenole und Thiole mittels LC‐MS/MS entwickelt.Mit der Kombination der neu entwickelten DGTA‐Derivatisierung sowie der etablierten 3NPH‐Derivatisierung für Carbonylgruppen war es möglich, zu zeigen, dass 23 der 27 Generalisten akkurat mittels LC‐MS/MS quantifiziert werden können. Die Quantifizierung der untersuchten Analyten wurde erfolgreich in verschiedenen Matrizes validiert und in diversen Lebensmitteln durchgeführt.Diese Methode ist für die Hochdurchsatzanalyse besonders geeignet, da sie hohe Genauigkeit aufgrund der Verwendung von stabilisotopenmarkierten internen Standards aufweist und weil die Probenextraktion durch Bead‐Beater‐Homogenisierung, schnell und vielseitig ist und nur geringe Probenmengen benötigt (0,5 g). Außerdem sind die verwendeten Derivatisierungen effizient und die LC‐MS/MS Analysenzeiten sind gering (12 min).
Vocal Cord Paralysis in Pediatric Chiari Malformation: A Systematic Review and Meta‐analysis
Authors: Vilarello Brandon J. , Maurrasse Sarah , Grunstein Eli , Jang Minyoung 
Published: July 2024

AbstractObjectiveArnold‐Chiari Malformation is one possible cause of congenital vocal cord paralysis (VCP). The natural history of VCP in children with Chiari malformation has previously been limited to small case studies. This systematic review seeks to better characterize the prognostic factors that may predict symptom severity and resolution of congenital VCP in children with Arnold‐Chiari malformation. We hypothesized that the onset of stridor or VCP at a younger age would be associated with a poorer prognosis and earlier intervention with posterior fossa decompression would be associated with better outcomes.Data SourcesPubMed, Web of Science, Cochrane Library, and bibliographic review.Review MethodsA systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines. Database search yielded 866 articles. Study abstracts were reviewed by 2 independent examiners. One hundred and seventy‐six studies underwent full‐text review. The following were extracted: age at onset of stridor or VCP, Chiari malformation type, laryngoscopy findings, type and timing of neurosurgical intervention, and tracheostomy history. Statistical analyses utilized χ2 tests.ResultsYounger age at symptom onset showed statistically significant associations with decreased likelihood for symptom resolution and tracheostomy decannulation. The shorter time interval from symptom onset to neurosurgical intervention was not significantly associated with better outcomes.ConclusionThis meta‐analysis suggests poorer prognosis in those with earlier‐onset symptoms, reinforcing prior case series findings. Additional prospective studies are needed to elucidate the natural history and utility of early intervention in children with vocal cord paralysis secondary to Chiari malformation.
Multifunctional skin dressings synthesized via one‐pot photopolymerization: Advancing wound healing and infection prevention strategies
Authors: Zambroni M. Emilia , Martínez Sol R. , Cagnetta Gonzalo E. , Ibarra Luis E. , Posadaz Ariana , Martucci Josefa F. , Romanini Silvia , Aramayo Ernesto Alejandro , Cabral Ana Lucía , Bertone Patricia , Palacios Rodrigo E. , Gómez María Lorena 
Published: July 2024

AbstractIn the field of wound healing treatment, the development of new materials is essential to cover multiple functions, such as acceleration of the healing process, prevention of infection and response to stimuli, especially if they present lower costs or are easier to manufacture. These properties are of great importance to prompt skin cicatrization. In this work, new multifunctional skin dressings for wound healing and infection prevention are developed based on new hydrogel materials. The dressings are produced via a straightforward and environmentally friendly one‐pot photopolymerization manufacturing process utilizing vitamin B2 aqueous solutions as sensitizer, and energy‐efficient blue light sources. These dressings exhibit a high swelling capacity, pH and temperature responsiveness, biocompatibility, antimicrobial activity in the absence of conventional antibiotics, and are capable of promoting wound healing. The formulation is based on the combination of three monomers: 2‐((methacryloyloxy)ethyl)trimethylammonium chloride, methacrylic acid and N‐vinyl caprolactam. Collagen, hyaluronic acid, and essential oil of hop are added to enhance antimicrobial properties and stimulate regenerative cellular processes. In vivo experiments have demonstrated that pristine dressings are superior in promoting collagen and fibroblast regeneration and accelerating cicatrization as compared to dressings containing natural products. The dressing embedded with hop also displayed antimicrobial characteristics. The preparation and testing of these new efficient wound dressings are described. This study is distinctive in its integration of environmentally conscious manufacturing techniques with innovative material formulations, resulting in superior wound dressings that are both cost‐effective and highly functional. By achieving enhanced healing and infection prevention without the employment of conventional antibiotics, this work represents a substantial advancement in sustainable and effective wound care management.
Surgical management of liver tumors
Authors: Riehle Kimberly J. , Vasudevan Sanjeev A. , Bondoc Alexander , Cuenca Alex G. , Garnier Hanna , Kastenberg Zachary , Roach Jonathan , Weldon Christopher B. , Karpelowsky Jonathan , Hishiki Tomoro , Tiao Gregory 
Published: July 2024

AbstractTwo percent of pediatric malignancies arise primarily in the liver; roughly 60% of these cancers are hepatoblastoma (HB). Despite the rarity of these cases, international collaborative efforts have led to the consistent histological classification and staging systems, which facilitate ongoing clinical trials. Other primary liver malignancies seen in children include hepatocellular carcinoma (HCC) with or without underlying liver disease, fibrolamellar carcinoma (FLC), undifferentiated embryonal sarcoma of the liver (UESL), and hepatocellular neoplasm not otherwise specified (HCN‐NOS). This review describes principles of surgical management of malignant pediatric primary liver tumors, within the context of comprehensive multidisciplinary care.