bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupation and its relationship with health and wellbeing: The threshold concept for occupational therapy
Authors: Fortune Tracy , Kennedy‐Jones Mary 
Published: August 2014

Background/aimWe introduce the educational framework of ‘threshold concepts’ and discuss its utility in understanding the fundamental difficulties learners have in understanding ways of thinking and practising as occupational therapists. We propose that the relationship between occupation and health is a threshold concept for occupational therapy because of students' trouble in achieving lasting conceptual change in relation to their understanding of it.MethodsThe authors present and discuss key ideas drawn from educational writings on threshold concepts, review the emerging literature on threshold concepts in occupational therapy, and pose a series of questions in order to prompt consideration of the pedagogical issues requiring action by academic and fieldwork educators.ResultsThreshold concepts in occupational therapy have been considered in a primarily cross‐disciplinary sense, that is, the understandings that occupational therapy learners grapple with are relevant to learners in other disciplines. In contrast, we present a more narrowly defined conception that emphasises the ‘bounded‐ness’ of the concept to the discipline.ConclusionA threshold concept that captures the essential nature of occupational therapy is likely to be (highly) troublesome in terms of a learner's acquisition of it. Rather than simplifying these learning ‘jewels’ educators are encouraged to sit with the discomfort that they and the learner may experience as the learner struggles to grasp them. Moreover, they should reshape their curricula to provoke such struggles if transformative learning is to be the outcome.
Resveratrol Preserves Mitochondrial Function, Stimulates Mitochondrial Biogenesis, and Attenuates Oxidative Stress in Regulatory T Cells of Mice Fed a High‐Fat Diet
Authors: Wang Bin , Sun Jin , Ma Yuhua , Wu Guirong , Tian Yingjie , Shi Yonghui , Le Guowei 
Published: August 2014

AbstractConsumption of high‐fat diet (HFD) is related with increased oxidative stress and dysfunctional mitochondria in many organs. The effects of resveratrol (trans‐3,5,4′‐trihydroxystilbene) that can protect T lymphocytes in various disease conditions on the HFD‐induced apoptosis of CD4+CD25+CD127low/− regulatory T cells (Tregs) were studied, and the possible mechanism was postulated. Resveratrol significantly decreased Tregs death induced by 20‐wk HFD, being associated with the reduction of reactive oxygen species production and the alleviation of HFD‐induced loss of mitochondrial membrane potential (Δψm) in Tregs. Furthermore, resveratrol increased the expression of factors that regulated mitochondrial biogenesis in Tregs. Finally, resveratrol recovered the HFD‐induced activation of apoptotic markers in Tregs. Resveratrol protected Tregs against HFD‐induced apoptosis by reducing oxidative stress, restoring mitochondrial functional activities, and stimulating mitochondrial biogenesis.
A Virtual Screening Method for Inhibitory Peptides of Angiotensin I–Converting Enzyme
Authors: Wu Hongxi , Liu Yalan , Guo Mingrong , Xie Jingli , Jiang XiaMin 
Published: August 2014

AbstractNatural small peptides from foods have been proven to be efficient inhibitors of Angiotensin I–converting enzyme (ACE) for the regulation of blood pressure. The traditional ACE inhibitory peptides screening method is both time consuming and money costing, to the contrary, virtual screening method by computation can break these limitations. We establish a virtual screening method to obtain ACE inhibitory peptides with the help of Libdock module of Discovery Studio 3.5 software. A significant relationship between Libdock score and experimental IC50 was found, Libdock score = 10.063 log(1/IC50) + 68.08 (R2 = 0.62). The credibility of the relationship was confirmed by testing the coincidence of the estimated log(1/IC50) and measured log(1/IC50) (IC50 is 50% inhibitory concentration toward ACE, in μmol/L) of 5 synthetic ACE inhibitory peptides, which was virtual hydrolyzed and screened from a kind of seafood, Phascolosoma esculenta. Accordingly, Libdock method is a valid IC50 estimation tool and virtual screening method for small ACE inhibitory peptides.
Ultra‐Performance Liquid Chromatographic Determination of L‐Ergothioneine in Commercially Available Classes of Cow Milk
Authors: Sotgia Salvatore , Pisanu Elisabetta , Cambedda Debora , Pintus Gianfranco , Carru Ciriaco , Zinellu Angelo 
Published: August 2014

AbstractA new efficient and sensitive precolumn hydrophilic interaction ultra‐performance liquid chromatography (HILIC‐UPLC) method was established for the quantitative determination of L‐ergothioneine (ERT) in milk. After derivatization of ERT with 7‐diethylamino‐3‐[4‐(iodoacetamido)phenyl]‐4‐methylcoumarin, chromatographic separation was achieved in a fairly short time, less than 5 min, on a 100 × 2.1 mm Waters Cortecs UPLC HILIC 1.6‐μm column, by using a mixture of 30 mmol/L ammonium acetate/acetonitrile (10:90, v/v) as a mobile phase flowing isocratically at 0.9 mL/min. Limit of detection and the limit of quantification were 0.03 and 0.10 μmol/L, respectively. The method exhibited linearity in a concentration range of 0.16 and 5.08 μmol/L. Mean recovery was 106.66%, whereas intra‐ and interassay precisions were determined to be within 6 RSD%. On average, ERT concentration in different commercially available classes of cow milk was found to be 0.442 ± 0.191 μmol/L, with the highest levels in the ultra‐high temperature milks and low values in the unprocessed and HTST whole milks. In this light, our experiments suggest that ERT could be used as a marker for the heat treatment of milk.
Analysis of the Subtropical Blackberry Cultivar Potential in Jelly Processing
Authors: Rios de Souza Vanessa , Aparecida Pimenta Pereira Patrícia , Carla Marques Pinheiro Ana , Carlos de Oliveira Lima Luiz , Pio Rafael , Queiroz Fabiana 
Published: August 2014

AbstractIn Brazil, there are numerous blackberry cultivars under cultivation, however, only a few cultivars, such as the Guarani, are displayed/used for processing. In this context the aim of this work was to study the effects of different Brazilian blackberry cultivars (Guarani, Brazos, Comanche, Tupy, Cherokee, Caingangue, and Choctaw) on the physicochemical characteristics, texture profiles and the consumer acceptance of the resulting jelly to identify the potential use of these cultivars in the jelly industry. It is feasible to produce blackberry jellies with the Tupy, Comanche, Brazos, Guarani, and Choctaw cultivars because these jellies demonstrated good acceptability combined with good productivity. Consumers were shown to have a preference for a less adhesive, more acidic jelly. This study provides a useful insight about the Brazilian blackberry cultivar potential in jelly processing.
Inhibitory Effects of Pomegranate Extracts on Recombinant Human Maltase–Glucoamylase
Authors: Kawakami Kayoko , Li Peng , Uraji Misugi , Hatanaka Tadashi , Ito Hideyuki 
Published: August 2014

Abstractα‐Glucosidase inhibitors are currently used in the treatment of type 2 diabetes. In this study, we investigated the inhibitory activities of aril and pericarp extracts from pomegranates obtained various regions against recombinant human maltase–glucoamylase (MGAM). The inhibitory activities of the aril extracts tended to be stronger than those of the pericarp extracts. The Iranian aril extract was the most effective inhibitor. We investigated the polyphenol content of the pomegranate extracts using the Folin–Ciocalteu method. Among the aril extracts, the Iranian aril extract showed the highest polyphenol content. We further evaluated inhibitory activity against α‐glucosidase from the rat small intestine. Pomegranate extract used in this study showed slightly different inhibitory activities according to α‐glucosidase origin. Iranian aril extract was the most effective inhibitor of α‐glucosidases, especially recombinant human MGAM. Bioassay‐guided fractionation of the pomegranate arils led to identification of punicalagin and oenothein B as potent inhibitors of α‐glucosidase. Oenothein B showed inhibitory activity with a half‐maximal inhibitory concentration (IC50) value of 174 μM. Its potency was comparable to that of the α‐glucosidase inhibitor acarbose with an IC50 value of 170 μM. Dixon plot kinetic analysis of oenothein B showed a noncompetitive inhibition with a Ki value of 102 μM. These results suggest that pomegranate arils would be useful for suppressing postprandial hyperglycemia.
Extraction Efficiency of Hydrophilic and Lipophilic Antioxidants from Lyophilized Foods Using Pressurized Liquid Extraction and Manual Extraction
Authors: Watanabe Jun , Oki Tomoyuki , Takebayashi Jun , Takano‐Ishikawa Yuko 
Published: August 2014

AbstractThe efficient extraction of antioxidants from food samples is necessary in order to accurately measure their antioxidant capacities. α‐Tocopherol and gallic acid were spiked into samples of 5 lyophilized and pulverized vegetables and fruits (onion, cabbage, Satsuma mandarin orange, pumpkin, and spinach). The lipophilic and hydrophilic antioxidants in the samples were sequentially extracted with a mixed solvent of n‐hexane and dichloromethane, and then with acetic acid–acidified aqueous methanol. Duplicate samples were extracted: one set was extracted using an automated pressurized liquid extraction apparatus, and the other set was extracted manually. Spiked α‐tocopherol and gallic acid were recovered almost quantitatively in the extracted lipophilic and hydrophilic fractions, respectively, especially when pressurized liquid extraction was used. The expected increase in lipophilic oxygen radical absorbance capacity (L‐ORAC) due to spiking with α‐tocopherol, and the expected increase in 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging activities and total polyphenol content due to spiking with gallic acid, were all recovered in high yield. Relatively low recoveries, as reflected in the hydrophilic ORAC (H‐ORAC) value, were obtained following spiking with gallic acid, suggesting an interaction between gallic acid and endogenous antioxidants. The H‐ORAC values of gallic acid–spiked samples were almost the same as those of postadded (spiked) samples. These results clearly indicate that lipophilic and hydrophilic antioxidants are effectively extracted from lyophilized food, especially when pressurized liquid extraction is used.
An Improved Approach to Identify Irradiated Spices Using Electronic Nose, FTIR, and EPR Spectroscopy
Authors: Sanyal Bhaskar , Ahn Jae‐Jun , Maeng Jeong‐Hwan , Kyung Hyun‐Kyu , Lim Ha‐Kyeong , Sharma Arun , Kwon Joong‐Ho 
Published: August 2014

AbstractChanges in cumin and chili powder from India resulting from electron‐beam irradiation were investigated using 3 analytical methods: electronic nose (E‐nose), Fourier transform infrared (FTIR) spectroscopy, and electron paramagnetic resonance (EPR) spectroscopy. The spices had been exposed to 6 to 14 kGy doses recommended for microbial decontamination. E‐nose measured a clear difference in flavor patterns of the irradiated spices in comparison with the nonirradiated samples. Principal component analysis further showed a dose‐dependent variation. FTIR spectra of the samples showed strong absorption bands at 3425, 3007 to 2854, and 1746 cm−1. However, both nonirradiated and irradiated spice samples had comparable patterns without any noteworthy changes in functional groups. EPR spectroscopy of the irradiated samples showed a radiation‐specific triplet signal at g = 2.006 with a hyper‐fine coupling constant of 3 mT confirming the results obtained with the E‐nose technique. Thus, E‐nose was found to be a potential tool to identify irradiated spices.
Simulating and detecting autocorrelation of molecular evolutionary rates among lineages
Authors: Ho Simon Y. W. , Duchêne Sebastián , Duchêne David 
Published: August 2014

AbstractEvolutionary timescales can be estimated from genetic data using phylogenetic methods based on the molecular clock. To account for molecular rate variation among lineages, a number of relaxed‐clock models have been developed. Some of these models assume that rates vary among lineages in an autocorrelated manner, so that closely related species share similar rates. In contrast, uncorrelated relaxed clocks allow all of the branch‐specific rates to be drawn from a single distribution, without assuming any correlation between rates along neighbouring branches. There is uncertainty about which of these two classes of relaxed‐clock models are more appropriate for biological data. We present an R package, NELSI, that allows the evolution of DNA sequences to be simulated according to a range of clock models. Using data generated by this package, we assessed the ability of two Bayesian phylogenetic methods to distinguish among different relaxed‐clock models and to quantify rate variation among lineages. The results of our analyses show that rate autocorrelation is typically difficult to detect, even when there is complete taxon sampling. This provides a potential explanation for past failures to detect rate autocorrelation in a range of data sets.
Gender Differences in Financial Reporting Decision Making: Evidence from Accounting Conservatism
Authors: Francis Bill , Hasan Iftekhar , Park Jong Chool , Wu Qiang 
Published: August 2014

AbstractThis paper investigates the effect of CFO gender on corporate financial reporting decision making. Focusing on firms that experience changes of CFO from male to female, the paper compares the firms' degree of accounting conservatism between pre‐ and post‐transition periods. We find that female CFOs are more conservative in their financial reporting. In addition, we find that the relation between CFO gender and conservatism varies with the level of various firm risks, including litigation risk, default risk, systematic risk, and CFO‐specific risk such as job security risk. We further find that the risk aversion of female CFOs is associated with less equity‐based compensation, lower firm risk, a higher tangibility level, and a lower dividend payout level. Overall, the study provides strong support for the notion that female CFOs are more risk averse than male CFOs, which leads female CFOs to adopt more conservative financial reporting policies.
Impact of ABCB1 single nucleotide polymorphisms 1236C>T and 2677G>T on overall survival in FLT3 wild‐type de novo AML patients with normal karyotype
Authors: Jakobsen Falk Ingrid , Fyrberg Anna , Paul Esbjörn , Nahi Hareth , Hermanson Monica , Rosenquist Richard , Höglund Martin , Palmqvist Lars , Stockelberg Dick , Wei Yuan , Gréen Henrik , Lotfi Kourosh 
Published: August 2014

SummaryDrug resistance is a clinically relevant problem in the treatment of acute myeloid leukaemia (AML). We have previously reported a relationship between single nucleotide polymorphisms (SNPs) of ABCB1, encoding the multi‐drug transporter P‐glycoprotein, and overall survival (OS) in normal karyotype (NK)‐AML. Here we extended this material, enabling subgroup analysis based on FLT3 and NPM1 status, to further elucidate the influence of ABCB1 SNPs. De novo NK‐AML patients (n = 201) were analysed for 1199G>A, 1236C>T, 2677G>T/A and 3435C>T, and correlations to outcome were investigated. FLT3 wild‐type 1236C/C patients have significantly shorter OS compared to patients carrying the variant allele; medians 20 vs. 49 months, respectively, P = 0·017. There was also an inferior outcome in FLT3 wild‐type 2677G/G patients compared to patients carrying the variant allele, median OS 20 vs. 35 months, respectively, P = 0·039. This was confirmed in Cox regression analysis. Our results indicate that ABCB1 1236C>T and 2677G>T may be used as prognostic markers to distinguish relatively high risk patients in the intermediate risk FLT3 wild‐type group, which may contribute to future individualizing of treatment strategies.
Designing N‐PolyVector Fields with Complex Polynomials
Authors: Diamanti Olga , Vaxman Amir , Panozzo Daniele , Sorkine‐Hornung Olga 
Published: August 2014

AbstractWe introduce N‐PolyVector fields, a generalization of N‐RoSy fields for which the vectors are neither necessarily orthogonal nor rotationally symmetric. We formally define a novel representation for N‐PolyVectors as the root sets of complex polynomials and analyze their topological and geometric properties. A smooth N‐PolyVector field can be efficiently generated by solving a sparse linear system without integer variables. We exploit the flexibility of N‐PolyVector fields to design conjugate vector fields, offering an intuitive tool to generate planar quadrilateral meshes.
Discrete 2‐Tensor Fields on Triangulations
Authors: de Goes Fernando , Liu Beibei , Budninskiy Max , Tong Yiying , Desbrun Mathieu 
Published: August 2014

AbstractGeometry processing has made ample use of discrete representations of tangent vector fields and antisymmetric tensors (i.e., forms) on triangulations. Symmetric 2‐tensors, while crucial in the definition of inner products and elliptic operators, have received only limited attention. They are often discretized by first defining a coordinate system per vertex, edge or face, then storing their components in this frame field. In this paper, we introduce a representation of arbitrary 2‐tensor fields on triangle meshes. We leverage a coordinate‐free decomposition of continuous 2‐tensors in the plane to construct a finite‐dimensional encoding of tensor fields through scalar values on oriented simplices of a manifold triangulation. We also provide closed‐form expressions of pairing, inner product, and trace for this discrete representation of tensor fields, and formulate a discrete covariant derivative and a discrete Lie bracket. Our approach extends discrete/finite‐element exterior calculus, recovers familiar operators such as the weighted Laplacian operator, and defines discrete notions of divergence‐free, curl‐free, and traceless tensors–thus offering a numerical framework for discrete tensor calculus on triangulations. We finally demonstrate the robustness and accuracy of our operators on analytical examples, before applying them to the computation of anisotropic geodesic distances on discrete surfaces.
Compressed Manifold Modes for Mesh Processing
Authors: Neumann T. , Varanasi K. , Theobalt C. , Magnor M. , Wacker M. 
Published: August 2014

AbstractThis paper introduces compressed eigenfunctions of the Laplace‐Beltrami operator on 3D manifold surfaces. They constitute a novel functional basis, called the compressed manifold basis, where each function has local support. We derive an algorithm, based on the alternating direction method of multipliers (ADMM), to compute this basis on a given triangulated mesh. We show that compressed manifold modes identify key shape features, yielding an intuitive understanding of the basis for a human observer, where a shape can be processed as a collection of parts. We evaluate compressed manifold modes for potential applications in shape matching and mesh abstraction. Our results show that this basis has distinct advantages over existing alternatives, indicating high potential for a wide range of use‐cases in mesh processing.
Feature‐Preserving Surface Completion Using Four Points
Authors: Harary Gur , Tal Ayellet , Grinspun Eitan 
Published: August 2014

AbstractWe present a user‐guided, semi‐automatic approach to completing large holes in a mesh. The reconstruction of the missing features in such holes is usually ambiguous. Thus, unsupervised methods may produce unsatisfactory results. To overcome this problem, we let the user indicate constraints by providing merely four points per important feature curve on the mesh. Our algorithm regards this input as an indication of an important broken feature curve. Our completion is formulated as a global energy minimization problem, with user‐defined spatial‐coherence constraints, allows for completion that adheres to the existing features. We demonstrate the method on example problems that are not handled satisfactorily by fully automatic methods.
Piecewise‐Planar 3D Reconstruction with Edge and Corner Regularization
Authors: Boulch Alexandre , de La Gorce Martin , Marlet Renaud 
Published: August 2014

AbstractThis paper presents a method for the 3D reconstruction of a piecewise‐planar surface from range images, typically laser scans with millions of points. The reconstructed surface is a watertight polygonal mesh that conforms to observations at a given scale in the visible planar parts of the scene, and that is plausible in hidden parts. We formulate surface reconstruction as a discrete optimization problem based on detected and hypothesized planes. One of our major contributions, besides a treatment of data anisotropy and novel surface hypotheses, is a regularization of the reconstructed surface w.r.t. the length of edges and the number of corners. Compared to classical area‐based regularization, it better captures surface complexity and is therefore better suited for man‐made environments, such as buildings. To handle the underlying higher‐order potentials, that are problematic for MRF optimizers, we formulate minimization as a sparse mixed‐integer linear programming problem and obtain an approximate solution using a simple relaxation. Experiments show that it is fast and reaches near‐optimal solutions.
3D Motion Completion in Crowded Scenes
Authors: Gafni Niv , Sharf Andrei 
Published: August 2014

AbstractCrowded motions refer to multiple objects moving around and interacting such as crowds, pedestrians and etc. We capture crowded scenes using a depth scanner at video frame rates. Thus, our input is a set of depth frames which sample the scene over time. Processing such data is challenging as it is highly unorganized, with large spatio‐temporal holes due to many occlusions. As no correspondence is given, locally tracking 3D points across frames is hard due to noise and missing regions. Furthermore global segmentation and motion completion in presence of large occlusions is ambiguous and hard to predict. Our algorithm utilizes Gestalt principles ofcommon fateandgood continuityto compute motion tracking and completion respectively. Our technique does not assume any pre‐given markers or motion template priors. Our key‐idea is to reduce the motion completion problem to a 1D curve fitting and matching problem which can be solved efficiently using a global optimization scheme. We demonstrate our segmentation and completion method on a variety of synthetic and real world crowded scanned scenes.
Real‐time Bas‐Relief Generation from Depth‐and‐Normal Maps on GPU
Authors: Ji Zhongping , Sun Xianfang , Li Shi , Wang Yigang 
Published: August 2014

AbstractTo design a bas‐relief from a 3D scene is an inherently interactive task in many scenarios. The user normally needs to get instant feedback to select a proper viewpoint. However, current methods are too slow to facilitate this interaction. This paper proposes a two‐scale bas‐relief modeling method, which is computationally efficient and easy to produce different styles of bas‐reliefs. The input 3D scene is first rendered into two textures, one recording the depth information and the other recording the normal information. The depth map is then compressed to produce a base surface with level‐of‐depth, and the normal map is used to extract local details with two different schemes. One scheme provides certain freedom to design bas‐reliefs with different visual appearances, and the other provides a control over the level of detail. Finally, the local feature details are added into the base surface to produce the final result. Our approach allows for real‐time computation due to its implementation on graphics hardware. Experiments with a wide range of 3D models and scenes show that our approach can effectively generate digital bas‐reliefs in real time.