bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Age‐Related Aortic Root Anatomic Changes on Left Ventricular Outflow Tract Pace‐Mapping Morphologies: A Cardiac Magnetic Resonance Imaging Validation Study
Authors: MAEDA SHINGO , CHIK WILLIAM W. , HAN YUCHI , LIANG JACKSON J. , SQUARA FABIEN , ARKLES JEFFREY S. , SADEK MOUHANNAD M. , SANTANGELI PASQUALE , FRANKEL DAVID S. , ZADO ERICA S. , TAKEBAYASHI SATOSHI , DIXIT SANJAY , CALLANS DAVID J. , MARCHLINSKI FRANCIS E. , LIN DAVID 
Published: May 2015

Age‐Related Changes in the Left Outflow TractIntroductionOutflow tract ventricular arrhythmias (OT VAs) are common and catheter ablation is an effective treatment option. We sought to investigate the relationship between age‐related anatomic aortic root changes and QRS morphology during left ventricular outflow tract (LVOT) pace‐mapping using cardiac magnetic resonance (CMR) imaging.Methods and ResultsFifty‐one patients undergoing CMR imaging were divided into 3 groups based on age (<40, 40–60, >60 years). We measured the angle of the aortic root, the aorta to ventricular septal angle, the distance between the right coronary cusp (RCC) and left coronary cusp (LCC), and the distance between the ascending and descending aorta. Additionally, we evaluated the QRS morphologies obtained during pace‐mapping from the LVOT. In older patients, LCC was more superior to the RCC (P < 0.01). Age was positively correlated with the aortic root angle (r2 = 0.481, P < 0.01) as well as the distances between the ascending and descending aorta at a level below the arch (r2 = 0.569, P < 0.01). In older patients, LVOT pace‐mapping (performed in 16 patients) demonstrated higher maximal R‐wave amplitude, and was greater when pacing from the LCC versus the RCC in lead III (1.8 ± 0.7 vs. 1.0 ± 0.5 mV, P = 0.02).ConclusionThe anatomy of the aortic root changes with age, and age‐related aortic root changes may affect the QRS morphology during pace‐mapping. Understanding the potential anatomic changes that accompany aging is important to maximize the efficacy of catheter ablation of OT VAs.
Difficult Hypertension Clinic Utilizing a Nurse Specialist: A Cost‐Efficient Model for the Modern Era?
Authors: van der Merwe Walter , van der Merwe Veronica 
Published: May 2015

In the modern era in New Zealand, there has been a lack of specialist hypertension clinics where family practitioners might refer patients with difficult‐to‐treat or resistant hypertension. A new specialist referral hypertension clinic was established in 2009 at North Shore Hospital, Auckland, employing a model of care where much of the follow‐up work is done by a nurse specialist. The authors review data from the first 1000 patients discharged from the clinic. Mean (treated) blood pressure improved by −26/12 mm Hg over an average of three visits, two thirds of which were to nurse specialist clinics. The authors propose this as a cost‐efficient model that could easily be duplicated in other centers.
The Weight of Society Over Time and Space: A Comprehensive Account of the Construction Material Stock of Japan, 1945–2010
Authors: Tanikawa Hiroki , Fishman Tomer , Okuoka Keijiro , Sugimoto Kenji 
Published: May 2015

SummaryIn order to fully comprehend the socioeconomic metabolic (SEM) dynamics and material balance of nations, long‐term accounting of economy‐wide material stock is necessary in parallel to material flow accounts. Nevertheless, material stock accounts have been scarce, isolated, and mostly focused either on single materials, short time spans, or small regions. This study has two objectives: (1) review the state of the art of material stock research in the SEM discourse and (2) present a project to map, in a high level of detail, the in‐use construction material stocks of Japan and its 47 prefectures from the 1940s until the present era. This project documents the two major depositories of material stock: buildings and infrastructure. We describe the challenges and benefits of utilizing a bottom‐up approach, in order to promote its usage in material stock studies. The resulting database presents the accumulation of stock over time, as well as visually displaying the spatial distribution of the stock using geographical information systems (GIS), which, we argue, is an essential aspect of material stock analysis in the context of socioeconomic metabolism research.
Hidden Liquidity: Some New Light on Dark Trading
Authors: BLOOMFIELD ROBERT , O'HARA MAUREEN , SAAR GIDEON 
Published: May 2015

ABSTRACTUsing a laboratory market, we investigate how the ability to hide orders affects traders’ strategies and market outcomes in a limit order book environment. We find that order strategies are greatly affected by allowing hidden liquidity, with traders substituting nondisplayed for displayed shares and changing the aggressiveness of their trading. As traders adapt their behavior to the different opacity regimes, however, most aggregate market outcomes (such as liquidity and informational efficiency) are not affected as much. We also find that opacity appears to increase the profits of informed traders but only when their private information is very valuable.
Stenting of Native Right Ventricular Outflow Tract Obstructions in Symptomatic Infants
Authors: BERTRAM HARALD , EMMEL MATHIAS , EWERT PETER , GROHMANN JOCHEN , HAAS NIKOLAUS A. , JUX CHRISTIAN , KEHL HANS GERD , KITZMÜller ERWIN , KRETSCHMAR OLIVER , MÜLLER GÖTZ , WIEBE WALTER ,   FOR THE INVESTIGATORS OF THE WORKING GROUP INTERVENTIONAL CARDIOLOGY OF THE GERMAN SOCIETY OF PEDIATRIC CARDIOLOGY
Published: May 2015

ObjectiveTo assess feasibility, safety and effectiveness of right ventricular outflow tract (RVOT) stenting in symptomatic young infants.MethodsMulticentre evaluation of 35 patients intended to undergo RVOT stenting in 11 pediatric cardiac centres from 2009 to August 2011.ResultsMedian age and weight at the time of first stent implantation were 8 weeks and 3.3 kg, with 40% of patients <3 kg. A total of 19 patients had suffered from hypoxemic spells, 8 patients were ventilated, 6 on inotropic support and 5 on prostaglandin infusion. Severe concomitant malformations were present in 11 patients, and acute infections in 2. Stenting of the RVOT was successfully performed in 33 patients, improving oxygen saturation from a median of 77 to 90% 2 days after intervention. Besides the 2 patients in whom RVOT stenting was not successful for technical reasons, there were no procedural complications. In 17 of 33 patients, 1–3 reinterventions were performed during follow‐up, less than half of those were reinterventions in the RVOT. A total of 27 patients have undergone successful surgical repair 4–162 (median 19.5) weeks after initial RVOT stent implantation, 2 patients are still waiting. There were no perioperative deaths.ConclusionsStenting of the RVOT provides a safe and effective management strategy for initial palliation in symptomatic young infants, including those patients not suitable or at higher risk for surgical therapy. (J Interven Cardiol 2015;28:279–287)
Does Preoperative Platelet Function Predict Bleeding in Patients Undergoing Off Pump Coronary Artery Bypass Surgery?
Authors: BERGER PETER B. , KIRCHNER H. LESTER , WAGNER ERIC S. , ISMAIL‐SAYED IBRAHIM , YAHYA SALMA , BENOIT CHARLES , BLANKENSHIP JAMES C. , CARTER RUSSELL , CASALE ALFRED S. , GREEN SANDY M. , SCOTT THOMAS D. , SKELDING KIMBERLY A. , WOODS EDWARD , HENRY YVETTE M. 
Published: May 2015

ObjectiveWe sought to examine the relationship between preoperative platelet function and perioperative bleeding in patients undergoing CABG.BackgroundThere are many ways to measure platelet aggregability. Little is known about their correlations with one another, or with bleeding.MethodsWe prospectively studied 50 patients undergoing a first isolated off‐pump CABG. Thirty‐four were exposed to a thienopyridine prior to surgery; 16 were not. Preoperative platelet function was measured by VerifyNow®, TEG®, AggreGuide™, Plateletworks®, vasodilator‐stimulated phosphoprotein (VASP) phosphorylation, and light transmission aggregometry. Bleeding was assessed 2 ways: drop from pre‐ to nadir postoperative hematocrit, and chest tube drainage. Correlation coefficients were calculated using Spearman's rank‐order correlation.ResultsMean age was 62 years. Patient characteristics and surgical details were similar between the thienopyridine‐exposed and non‐exposed patients. The correlation coefficients between the 4 point‐of‐care platelet function measurements and hematocrit change ranged from −0.2274 to 0.2882. Only Plateletworks® correlated with drop in hematocrit (r = 0.2882, P = 0.0470). The correlation coefficients between each of the 4 point‐of‐care platelet function tests and the chest tube drainage were also poor, ranging from −0.3073 to 0.2272. Both AggreGuide™ (r = −0.3073, P = 0.0317) and VASP (r = −0.3187, P = 0.0272) were weakly but significantly correlated with chest tube drainage. The correlation among the 4 point‐of‐care platelet function measurements was poor, with coefficients ranging from −0.2504 to 0.1968.ConclusionsWe observed little correlation among 4 platelet function tests, and between those assays and perioperative bleeding defined 2 different ways. Whether any of these assays should be used to guide decision making in individual patients is unclear. (J Interven Cardiol 2015;28:223–232)
Comparison of Cutting Balloon Angioplasty and Percutaneous Balloon Angioplasty of Arteriovenous Fistula Stenosis: A Meta‐Analysis and Systematic Review of Randomized Clinical Trials
Authors: AGARWAL SHIV KUMAR , NADKARNI GIRISH N. , YACOUB RABI , PATEL ACHINT A. , JENKINS JAMES S. , COLLINS TYRONE J. , ANNAPUREDDY NARENDER , KUMBALA DAMODAR , BODANA SHIRISHA , BENJO ALEXANDRE M. 
Published: May 2015

BackgroundHemodialysis (HD) access failure is a common cause of increased morbidity and healthcare cost in patients with end stage renal disease (ESRD). Percutaneous balloon angioplasty has been used to treat hemodialysis access stenosis but is complicated by a high rate of restenosis. Percutaneous cutting balloon (PCB) angioplasty is an alternative approach that has shown to reduce restenosis.ObjectivesThe aim of the study is to assess the safety and efficacy of PCB angioplasty in comparison with conventional and high‐pressure balloon angioplasty in the treatment of hemodialysis access site stenosis.MethodsWe searched PubMed, EMBASE and the Cochrane Central register of controlled trials (CENTRAL) databases through August 2014 and selected studies using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) checklist. We included all randomized clinical trials with a head‐to‐head comparison between PCB and conventional or high‐pressure balloon angioplastyResultsThree studies with 1034 participants (age 60.7 (±12.9) years and 50.1% males) with 525 in PCB and 509 in control arm were included in the analysis. The immediate procedural success rate was not significantly different in the PCB angioplasty and control arm respectively, (87.2% vs. 83.7% RD −0.02; 95%CI −0.06 to 0.01; P = 0.38). The six‐month target lesion patency was significantly higher in the PCB angioplasty arm (67.2% vs. 55.6% RD 0.12; 95%CI 0.05–0.19; P < 0.05) with number needed to treat (NNT) of 9. The device related complications were not statistically significant between groups (RD 0.03; 95%CI −0.02 to 0.07; P = 0.26).ConclusionsPCB angioplasty is effective in treatment of hemodialysis access stenosis, with significantly higher six‐month patency compared to balloon angioplasty. (J Interven Cardiol 2015;28:288–295)
Reduced Glutathione for Prevention of Renal Outcomes in Patients Undergoing Selective Coronary Angiography or Intervention
Authors: WANG CHUNRUI , WANG WENJI , MA SHUAI , LU JIANXIN , SHI HAIMING , DING FENG 
Published: May 2015

ObjectivesTo evaluate the effect of reduced glutathione on renal outcomes following the selective coronary angiography and/or intervention.BackgroundContrast agents can cause an acute reduction in renal function that may be due to the generation of reactive oxygen species. The role of antioxidants in prevention of this renal impairment is controversial.Methods and ResultsWe conducted a randomized, placebo‐controlled trial of reduced glutathione in 825 patients who underwent selective coronary angiography and/or intervention. Patients were assigned to reduced glutathione 1800 mg (n = 416) or placebo (n = 411) intravenously. Contrast‐induced acute kidney injury was defined by an absolute increase of serum creatinine ≥0.5 mg/dl (44.2 μmol/L) or a relative increase of ≥25% measured 48 hours after the procedure. The incidence of contrast‐induced acute kidney injury was 5.07% in the glutathione group and 4.97% in the control group (relative risk, 1.04; 95% confidence interval, 0.59–1.83; P = 0.886). Change in serum malondialdehyde was (−) 1.01 ± 1.69 nmol/ml in the glutathione group and (−) 0.67 ± 1.55 nmol/ml in the control group (P = 0.054), and change in serum total antioxidant capacity level was also similar in both groups (0.91 ± 2.06 nmol/ml and 0.79 ± 2.18 nmol/ml, respectively; P = 0.936).ConclusionsA single dose of reduced glutathione does not reduce the risk of contrast‐induced acute kidney injury in patients undergoing coronary angiography and/or intervention. (J Interven Cardiol 2015;28:249–256)
Long‐Term Effects of Novel Combination Coating Anti‐CD34 Antibody Applied on Sirolimus‐Eluting Stents
Authors: CHEN FENG , YANG FENG , ZHAO QIAN , FENG SHICHAO , LI WEIXIAO , BI YONGHUA , ZHANG SHIXUAN , WANG YANG , FENG BO 
Published: May 2015

ObjectivesWe investigated whether the combination coating of a novel “prohealing coating” hyaluronan‐chitosan (HC) and anti‐CD34 antibody applied on an SES (HCASES) can reduce neointimal formation while promoting endothelialization compared to either agent alone.BackgroundDrug‐eluting stents have considerably reduced the incidence of in‐stent restenosis compared with bare metal stents. However, the beneficial effect of drug elution is overshadowed by delayed re‐endothelialization as well as later “catch‐up” proliferation related to the drug.MethodsThree different stents: Sirolimus‐eluting stents (SES), Genous anti‐CD34 antibody stents (GS), and the combination of HC‐anti‐CD34 antibody with sirolimus‐eluting stents (HCASES) were deployed in 54 normal porcine coronary arteries and harvested for scanning electron microscopy (SEM) and histological analysis at 60, 90, and 120 days.ResultsAt 60 and 90 days, SEM analysis showed stent surface endothelial coverage was nearly completed in the HCASES (87 ± 3%, 95 ± 3%) compared with that in the SES (68 ± 6%, 77 ± 8%, P = 0.03). Histological examination at 90 days showed that the HCASES group had less percentage of stenosis than the GS group (P < 0.05). At 120 days, SEM showed a significantly higher extent of endothelial coverage above struts in the HCASES (96 ± 2%) and the GS (95 ± 3%) as compared with the SES group (66 ± 3%; P = 0.02). The HCASES group showed less stenosis than that in the GS group (P < 0.05), but it was not significantly different from the SES group (P = 0.063).ConclusionsHistological and SEM analyses demonstrate that the HCASES can reduce neointimal formation and inflammation while promoting endothelialization in the long term. (J Interven Cardiol 2015;28:257–263)
Fluidity, Identity, and Organizationality: The Communicative Constitution of Anonymous
Authors: Dobusch Leonhard , Schoeneborn Dennis 
Published: May 2015

AbstractThis paper examines how fluid social collectives, where membership is latent, contested, or unclear, achieve ‘organizationality’, that is, how they achieve organizational identity and actorhood. Drawing on the “communicative constitution of organizations” perspective, we argue that the organizationality of a social collective is accomplished through ‘identity claims’ – i.e., speech acts that concern what the social collective is or does – and negotiations on whether or not these claims have been made on the collective's behalf. We empirically examine the case of the hacker collective Anonymous and analyse relevant identity claims to investigate two critical episodes in which the organizationality of Anonymous was contested. Our study contributes to organization studies by showing that fluid social collectives are able to temporarily reinstate organizational actorhood through the performance of carefully prepared and staged identity claims.
Peroxiredoxin 1 inhibits the oxidative stress induced apoptosis in renal tubulointerstitial fibrosis
Authors: Mei Wenjuan , Peng Zhangzhe , Lu Miaomiao , Liu Chunyan , Deng Zhenghao , Xiao Yun , Liu Jishi , He Ying , Yuan Qiongjing , Yuan Xiangning , Tang Damu , Yang Huixiang , Tao Lijian 
Published: May 2015

AbstractAimApoptosis is one of the most important mechanisms underlying renal tubulointerstitial fibrosis. We identified a role of protein Peroxiredoxin 1 (Prx1) in protecting apoptosis occurred in tubular epithelial cells of the rat and human kidney.MethodsImmunohistochemistry (IHC) staining was used to detect Prx1 expression in kidney derived from unilateral‐ureteral obstruction (UUO) rats or patients with obstructive nephropathy. Modulation of Prx1 expression by transfecting siRNA and overexpression plasmid approach were carried out in NRK‐52E (rat kidney tubular epithelial cell line) cells. UUO‐induced apoptosis was determined using TUNEL assay.ResultsImmunohistochemistry staining showed that Prx1 expressed in the cytoplasm of renal tubular epithelial cells, in the kidneys of UUO rats. The reduction was confirmed by both IHC and real‐time polymerase chain reaction following a course of renal tubulointerstitial fibrosis in UUO rats and a decrease of Prx1 occurred concomitantly with an elevation of TUNEL‐positive cells. Fluorofenidone (AKF‐PD), a new anti‐tubulointerstitial fibrotic agent, attenuated Prx1 reduction in UUO rats. Furthermore, hydrogen peroxide (H2O2)‐derived oxidative stress activated p38 MAPK, and induced apoptosis in NRK‐52E cells; knockdown of Prx1 sensitized both events in NRK‐52E cells, and overexpression of Prx1 diminished the apoptosis and the phosphorylation of p38ConclusionDownregulation of Prx1 occurred in renal tubular epithelial cells of UUO rats and patients with obstructive nephropathy. Prx1 may alleviate the pathogenesis by inhibiting H2O2‐induced apoptosis via inhibiting the p38 MAPK pathway. Prx1 may represent a useful target for a protective therapy towards renal tubulointerstitial fibrosis.
Superficial and Deep Infiltrating Congenital Juvenile Xanthogranuloma Involving Multiple Skeletal Muscles and Associated with Ulceration and Generalized Postinvolution Atrophy
Authors: Moon Hye‐Rim , Won Chong Hyun , Chang Sung Eun , Lee Mi Woo , Choi Jee Ho , Moon Kee Chan 
Published: May 2015

AbstractWe present a 2‐day‐old boy with a deep‐seated giant juvenile xanthogranuloma infiltrating the skeletal muscles on his right lower limb. Unlike typical juvenile xanthogranuloma, the lesion has shown only partial spontaneous regression with large atrophic scar. However, despite the involvement multiple muscle on the right thigh, the patient has no evidence of orthopaedic sequelae.
Involvement of NtERF3 in the cell death signalling pathway mediated by SIPK/WIPK and WRKY1 in tobacco plants
Authors: Ogata T. , Okada H. , Kawaide H. , Takahashi H. , Seo S. , Mitsuhara I. , Matsushita Y. 
Published: May 2015

AbstractWe previously reported that one of the ethylene response factors (ERFs), NtERF3, and other members of the subgroup VIII‐a ERFs of the AP2/ERF family exhibit cell death‐inducing ability in tobacco leaves. In this study, we focused on the involvement of NtERF3 in a cell death signalling pathway in tobacco plants, particularly downstream of NtSIPK/NtWIPK and NtWRKY1, which are mitogen‐activated protein kinases and a phosphorylation substrate of NtSIPK, respectively. An ERF‐associated amphiphilic repression (EAR) motif‐deficient NtERF3b mutant (NtERF3bΔEAR) that lacked cell death‐inducing ability suppressed the induction of cell death caused by NtERF3a. The transient co‐expression of NtERF3bΔEAR suppressed the hypersensitive reaction (HR)‐like cell death induced by NtSIPK and NtWRKY1. The induction of cell death by NtSIPK and NtWRKY1 was also inhibited in transgenic plants expressing NtERF3bΔEAR. Analysis of gene expression, ethylene production and cell death symptoms in salicylic acid‐deficient tobacco plants suggested the existence of some feedback regulation in the HR cell death signalling pathway mediated by SIPK/WIPK and WRKY1. Overall, these results suggest that NtERF3 functions downstream of NtSIPK/NtWIPK and NtWRKY1 in a cell death signalling pathway, with some feedback regulation.
Heterosides – compatible solutes occurring in prokaryotic and eukaryotic phototrophs
Authors: Hagemann M. , Pade N. 
Published: May 2015

AbstractThe acclimation to osmotic and/or salt stress conditions induces an integrated response at different cellular levels. One acclimation strategy relies on the massive accumulation of low molecular mass compounds, so‐called compatible solutes, to balance osmotic gradients and to directly protect critical macromolecules. Heterosides are compounds composed of a sugar and a polyol moiety that represent one chemical class of compatible solutes with interesting features. Well‐investigated examples are glucosylglycerol, which is found in many cyanobacteria, and galactosylglycerols (floridoside and isofloridoside), which are accumulated by eukaryotic algae under salt stress conditions. Here, we review knowledge on physiology, biochemistry and genetics of heteroside accumulation in pro‐ and eukaryotic photoautotrophic organisms.
Comparative Development of Embryonic Age by Organogenesis in Domestic Dogs and Cats
Authors: Pieri NCG , Souza AF , Casals JB , Roballo KCS , Ambrósio CE , Martins DS 
Published: May 2015

ContentsThe precise determination of the embryonic chronology is very important in reproductive biotechnologies, especially in estimating embryonic age. Thus, there is a need for greater knowledge and standardization for determining the chronology of embryonic development and functional morphology. We describe aspects of embryonic development in two domestic carnivores to add knowledge about organ peculiarities and for application in veterinary practice, in prenatal development and in the biotechnology fields. We found that the development of differential characteristics of embryonic organs occurs in the first trimester of pregnancy for both species. Thus, using the combination of the crown‐rump length, macroscopic analysis and optical microscopy, it is possible to predict gestational age more precisely in animals that lack a defined breed and establish an embryonic pattern.
Food Demand Characteristics inUganda: Estimation and Policy Relevance
Authors: Boysen Ole 
Published: May 2015

AbstractUganda was highly successful in reducing poverty over the past two decades but made little progress towards household food security. This underlines the need for designing food security interventions customised for household‐specific needs and behaviours. This study estimatesUgandan household demand behaviour with a focus on food consumption paying particular attention to household‐specific characteristics. The results show that preferences to increase calorie‐dense staple consumption, likely associated with food energy deficiency, extend far beyond the percentage of ruralUgandans officially deemed poor. Price elasticities indicate that poor rural households are largely well positioned to compensate staple price increases by substitution as long as they are not already concentrated on the cheapest foods. This flexibility applies less to urban households. The estimated demand elasticities generally vary widely between rural and urban households and depend on expenditure levels. Household‐specific characteristics have significant, sometimes pronounced, influences on demand, as do seasons and regions. The results reflect highly differentiated demand behaviour, which can be utilised to improve the design and evaluation of food security interventions.