bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative modeling and analysis of supply chain risks using Bayesian theory
Authors: Badurdeen Fazleena , Shuaib Mohannad , Wijekoon Ken , Brown Adam , Faulkner William , Amundson Joseph , Jawahir I.S. , J. Goldsby Thomas , Iyengar Deepak , Boden Brench 
Published: June 2014

Purpose
– Globally expanding supply chains (SCs) have grown in complexity increasing the nature and magnitude of risks companies are exposed to. Effective methods to identify, model and analyze these risks are needed. Risk events often influence each other and rarely act independently. The SC risk management practices currently used are mostly qualitative in nature and are unable to fully capture this interdependent influence of risks. The purpose of this paper is to present a methodology and tool developed for multi-tier SC risk modeling and analysis.

Design/methodology/approach
– SC risk taxonomy is developed to identify and document all potential risks in SCs and a risk network map that captures the interdependencies between risks is presented. A Bayesian Theory-based approach, that is capable of analyzing the conditional relationships between events, is used to develop the methodology to assess the influence of risks on SC performance

Findings
– Application of the methodology to an industry case study for validation reveals the usefulness of the Bayesian Theory-based approach and the tool developed. Back propagation to identify root causes and sensitivity of risk events in multi-tier SCs is discussed.

Practical implications
– SC risk management has grown in significance over the past decade. However, the methods used to model and analyze these risks by practitioners is still limited to basic qualitative approaches that cannot account for the interdependent effect of risk events. The method presented in this paper and the tool developed demonstrates the potential of using Bayesian Belief Networks to comprehensively model and study the effects or SC risks. The taxonomy presented will also be very useful for managers as a reference guide to begin risk identification.

Originality/value
– The taxonomy developed presents a comprehensive compilation of SC risks at organizational, industry, and external levels. A generic, customizable software tool developed to apply the Bayesian approach permits capturing risks and the influence of their interdependence to quantitatively model and analyze SC risks, which is lacking.
Interview with Dr Rosalie Tung: a cross-cultural studies researcher and published author
Authors: Murillo Rocio 
Published: June 2014

Purpose
– This interview was conducted with Dr Rosalie Tung. Dr Tung gives her insight about her career.

Design/methodology/approach
– Interview was conducted via Skype. There was a somewhat systematical approach to the Q&A interview.

Findings
– Dr Tung briefly goes through her academic career regarding cross-cultural studies and how her life experiences shaped her passion for the subject.

Originality/value
– This was a one-on-one interview via Skype.
Defining perceived employability: a psychological approach
Authors: Vanhercke Dorien , De Cuyper Nele , Peeters Ellen , De Witte Hans 
Published: June 2014

Purpose– The purpose of this paper is to define employability within the psychological literature with a focus upon perceived employability.Design/methodology/approach– To achieve the aim, the paper defines five objectives as follows. First, the paper discusses how employability is interpreted in the psychological literature. Second, the paper defines perceived employability within this literature. Third, the paper goes one step further by comparing the perceived employability approach to other approaches in the psychological field, namely, approaches based on competences and dispositions. The paper concludes with an integration of the three approaches into a process model to demonstrate their interrelationships, which the authors see as the fourth objective. With approach, the paper refers to a specific view on employability, including both definitions and measures, which share significant common ground. Finally, the paper highlights some implications.Findings– The paper concludes that each approach comes with specific advantages and disadvantages. Researchers and practitioners should use an approach according to the general research question one aims to address.Originality value– The authors believe to contribute to the employability literature in the following ways. First, the paper raises awareness that not all psychological notions of employability are equal, though they are often treated as such in the literature. Second, the paper highlights how perceived employability is tied to competences and dispositions. That is, though all notions are clearly different, they are also related.
2.5 million hectares and one sustainable goal
Authors: A. Moscovici Daniel 
Published: June 2014

Purpose
– The purpose of this paper is to investigate historical environmental destruction and subsequent land use policies enacted over the last 400 years in the Adirondacks Park & Preserve – America's largest park and preserve in the lower 48 states.

Design/methodology/approach
– The paper includes a historical analysis using an extensive literature review. The historical analysis is divided into four distinct waves of time analyzing the specific environmental destruction and the policies enacted. They closely mimic century waves: 1700s, 1800s, 1900s, and the present 2000s.

Findings
– Findings indicate that each of the major policy or land use instruments applied to the Adirondack region were appropriate at the time, however, were retroactive approaches to stem widespread environmental devastation. These strong measures still impact the region today, impairing the 2.5 million ha and the ability to ensure a sustainable future of environmental protection, economic prosperity, and societal well-being. The conservation easement as a tool can proactively return the region to a sustainable balance.

Originality/value
– While there have been studies analyzing the historical importance and others highlighting the political uniqueness of the Adirondacks, this paper fills the gap in reframing the history and policies in a sustainable planning paradigm. Exposing retroactive responses when the environment was on the brink of destruction, the paper suggests a proactive approach using the conservation easement. Here, sustainability can be achieved through partnership between government, non-profit, and private business. This collaboration can build on one of the best regional planning models in the nation and ensure a balance between environment, economy, and society for more than one century wave.
Who will care for older people in China? Exploring the implications of gender imbalance at birth
Authors: Kadoya Yoshihiko , Yin Ting 
Published: June 2014

Purpose
– The purpose of this paper is to provide evidence about the possible cause and effect of the problematic gender imbalance at birth in China. Much of the literature on this issue presents discussions based on the traditional assumption that Chinese sons are more involved in taking care of parents than Chinese daughters are, and thus, that Chinese parents prefer sons. Yet, empirical evidence is lacking.

Design/methodology/approach
– This paper verifies the assumption by using the “Preference Parameters Study in China 2011,” which conducted 652 face-to-face interviews with randomly selected individuals in six major Chinese cities.

Findings
– This paper first presents empirical evidence that Chinese sons (and their wives) are more likely, compared to daughters (and their husbands), to be primary caregivers for parents. The paper also reports the finding that Chinese parents’ dependencies on their children would not necessarily decrease with the development of social security, although that may be the case when a child has a highly educated spouse.

Practical implications
– The Chinese government needs to increase long-term care services for older people, especially since more women are being educated.

Originality/value
– Although this study has data collection limitations, with data collected in only six major cities, the problematic nature of gender imbalance at birth and the lack of available empirical evidence demand that researchers begin to construct a better understanding of the causes of, and possible solutions to, this phenomenon. With that in mind, this paper contributes to that construction of knowledge and insight.
Progress towards Healthy Ageing in Europe: to promote active healthy lifestyles in 45-68 year olds through workplace, rather than traditional health-related settings
Authors: Anne Gibson Elspeth 
Published: June 2014

Purpose
– Progress towards Healthy Ageing in Europe has been a two-year European funded project led by Suffolk County Council Public Health and involving five European Union (EU) member nations. The purpose of this paper is to share the learning from the project as it relates to early preventative activity to promote healthy active ageing. The population of interest are those people in the mid-life age group of 45-68 years accessed via the workplace.

Design/methodology/approach
– Qualitative research applying an online Health Manager tool and focus group discussions. Transnational work to learn from other EU countries about approaches to promote healthy active ageing.

Findings
– A comprehensive account of all project findings is available via the following web site: www.progresshealthyageing.eu This paper outlines the findings from the UK regional activity of the application of an online Health Manager™ tool to employees from Suffolk in the 45-68 year age group.

Research limitations/implications
– The research limitations related to smaller cohorts (ca. 1,000 participants) as opposed to large-scale surveys. The phenomenon of the “healthy worker effect” (Shah, 2009), may be a limitation as the population of interest in this age group were mainly employed and in paid employment. The healthy worker effect implies that those who are employed are already “healthier” due to being employed. The further limitation of the timescale for the intervention and project funding as a resource limitation precludes longer term follow-up and evidence collection to find out if behaviour change in participants has been sustained over time.

Social implications
– The findings of the EU Project have contributed towards the Europe 2020 Strategy. Locally the findings from the project have supported Suffolk County Council's ambition to be the most active county in England. The findings have added momentum to local workplace health initiatives by providing a focus for the needs of the older workforce. Learning from the Project has also informed development of the Suffolk Workplace Challenge.

Originality/value
– This paper provides a review on a European project, Progress towards Healthy Ageing in Europe.
Coadministration of β‐asarone and levodopa increases dopamine in rat brain by accelerating transformation of levodopa: A different mechanism from Madopar
Authors: Huang Liping , Deng Minzhen , Zhang Sheng , Fang Yongqi , Li Ling 
Published: June 2014

SummaryThe aim of the present study was to investigate the effect of coadministration of β‐asarone and levodopa (l‐dopa) on increasing dopamine (DA) in the striatum of healthy rats. Rats were randomly divided into four groups: (i) a normal group, administered normal saline; (ii) a Madopar group, administered 75 mg/kg Madopar (l‐dopa : benserazide, 4 : 1); (iii) an l‐dopa group, administered 60 mg/kg l‐dopa; and (iv) a group coadministered 15 mg/kg β‐asarone and 60 mg/kg l‐dopa. All drugs (or normal saline) were administered intragastrically twice a day for 7 days. Then, plasma and striatum concentrations of DA, l‐dopa, 5‐hydroxytryptamine (5‐HT), homovanillic acid (HVA), 3,4‐dihydroxyphenylacetic acid (DOPAC), tyrosine hydroxylase (TH), catechol‐O‐methyltransferase (COMT) and monoamine oxidase B (MAO‐B) were determined. In the group coadministered β‐asarone and l‐dopa, there was a decline in plasma and striatal concentrations of l‐dopa; however, DA and DOPAC concentrations increased in the striatum and plasma and plasma HVA concentrations increased, whereas there was no significant change in striatal levels. Concentrations of 5‐HT in the striatum and plasma were similar in the coadministered and Madopar‐treated groups. In addition, plasma and striatal COMT levels decreased after coadministration of β‐asarone and l‐dopa, whereas there were no significant differences in MAO‐B concentrations among groups. Furthermore, coadministration of β‐asarone and l‐dopa increased plasma TH concentrations. Altogether, β‐asarone affects the conversion of l‐dopa to DA by modulating COMT activity and DA metabolism. The mechanism of coadministration is different from that of Madopar in Parkinson's disease (PD) treatment. Thus, the coadministration of β‐asarone and l‐dopa may be beneficial in the treatment of PD.
Emerging role of cystic fibrosis transmembrane conductance regulator as an epigenetic regulator: linking environmental cues to microRNAs
Authors: Chan Hsiao Chang , Jiang Xiaohua , Ruan Ye Chun 
Published: June 2014

SummaryAlthough microRNAs (miRNAs) have been recognized as one of the important epigenetic mechanisms that regulate gene expression in response to changes in the environment, the links between environmental cues and changes in miRNAs remain largely unknown. Localized to the cell membrane and recognized as an anion channel, the cystic fibrosis transmembrane conductance regulator (CFTR) has recently been shown to mediate important signalling pathways leading to activation of miRNAs. This brief review summarizes the related findings and discusses the emerging role of CFTR as an epigenetic regulator, possibly involved in a wide spectrum of physiological and pathological processes.
Inhibitory action of naphtho[1,2‐b]furan‐4,5‐dione on hepatocyte growth factor‐induced migration and invasion of MDA‐MB‐231 cells: Mechanisms of action
Authors: Tsai Pei‐Chien , Chu Chiao‐Lun , Tseng Chih‐Hua , Chen Yeh‐long , Chang Long‐Sen , Lin Shinne‐Ren 
Published: June 2014

SummaryNaphtho[1,2‐b]furan‐4,5‐dione (NFD), a bioactive component of Avicennia marina, has been shown to exhibit anticancer activity. The aim of the present study was to explore the effect of NFD on hepatocyte growth factor (HGF)‐induced cell migration and invasion of MDA‐MB‐231 human breast cancer cells, as well as the underlying mechanism of action. Cell viability was determined using the 3‐(4,5‐dimethyl‐2 thiazoyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide assay, western blot analysis was used to measure protein expression and cell migration and invasion were evaluated by the cell wound healing assay, Boyden chamber assay and gelatin zymography. When cells were treated with non‐toxic concentrations of NFD (1–3 μmol/L, 24 h), NFD concentration‐dependently inhibited HGF‐promoted cell migration and invasion. Simultaneously, NFD efficiently suppressed c‐Met phosphorylation and downstream activation of phosphatidylinositol 3‐kinase (PI3K) and Akt. In addition, NFD inhibited the phosphorylation of IκB kinases and IκBα and nuclear translocation of nuclear factor (NF)‐κB, as well as matrix metalloproteinase (MMP)‐9 activity. Furthermore, the c‐Met inhibitor PHA665752 (10 μmol/L) inhibited HGF‐induced MMP‐9 expression, cell migration and invasion, as well as the activation of PI3K/Akt, suggesting that PI3K/Akt activation occur downstream of c‐Met activation. In conclusion, the results of the present study suggest that NFD inhibits HGF‐induced invasion and migration of MDA‐MB‐231 cells via HGF‐ and/or c‐Met‐mediated PI3K/Akt and NF‐κB signalling pathways, leading to downregulation of MMP‐9 expression and cell migration.
Stimulation of electroporation‐induced inward currents in glioblastoma cell lines by the heat shock protein inhibitor AUY922
Authors: Chiang Nai‐Jung , Wu Sheng‐Nan , Kao Ching‐An , Huang Yan‐Ming , Chen Li‐Tzong 
Published: June 2014

SummaryMembrane electroporation (MEP) increases the electrical conductivity of the plasma membrane by addition of an external electrical field. Combining MEP‐induced current (IMEP) with antineoplastic agents has been increasingly considered as a new therapeutic manoeuvre, especially in the treatment of malignant gliomas. Thus, the aim of the present study was to evaluate the effect of AUY922 (AUY), a potent inhibitor of heat‐shock protein 90 (HSP90), on IMEP in glioblastoma cells. The IMEP in glioblastoma cells (U373) was generated by repetitive hyperpolarization from −80 to −200 mV. The amplitude of IMEP was increased by AUY in a concentration‐dependent manner, with an EC50 of 0.32 μmol/L. In addition AUY shortened the latency to IMEP generation. Before depolarization to +50 mV, hyperpolarization to −200 mV for 50 msec produced Ca2+ influx and subsequently increased the amplitude of the Ca2+‐activated K+ current (IK(Ca)). The amplitude of IK(Ca) and Ca2+ influx was further increased by AUY through its ability to activate IMEP. Other HSP90 inhibitors, namely 17‐(allylamino)‐17‐demethoxygeldanamycin (17‐AAG; 1 μmol/L) and 6‐chloro‐9‐[(4‐methoxy‐3,5‐dimethylpyridin‐2‐yl)methyl]‐9H‐purin‐2‐amine (BIIB021; 1 μmol/L), only slightly (albeit significantly) increased the amplitude of IMEP in glioblastoma cells. A 50 msec depolarizing step elevated Ca2+ influx and subsequently increased the amplitude of IK(Ca) in the presence of these three inhibitors. These data indicate that the AUY‐mediated stimulation of IMEP and IK(Ca) in glioblastoma cells is independent of HSP90 inhibition. Moreover, these results indicate that AUY‐stimulated IMEP and the subsequent activation of IK(Ca) may create important signalling events in glioblastoma cells. Thus, AUY is a drug that could potentially be used to augment the effectiveness of electrochemotherapy.
Outcome of Patients with Severe PH due to Lung Disease with and without Targeted Therapy
Authors: Lange Tobias J. , Baron Miriam , Seiler Isabella , Arzt Michael , Pfeifer Michael 
Published: June 2014

SummaryIntroductionPulmonary hypertension (PH) can occur in patients with lung disease and worsen prognosis. Endothelin receptor antagonists, phosphodiesterase 5‐inhibitors, and prostacyclin analogs, referred to as targeted therapy, have not been shown in a limited number of controlled clinical studies to improve exercise capacity in these patients. Possibly targeted therapy could be of benefit in patients with severe PH due to lung disease, but this subgroup is not well studied.AimsTo analyze influence of PH severity and use of targeted therapy on exercise capacity and survival in patients with PH due to lung disease.MethodsConsecutive patients with PH (mean pulmonary artery pressure ≥25 mmHg at rest) due to lung disease diagnosed by right heart catheterization between 1/2005 and 9/2011 were retrospectively included. Severe PH was defined as mean pulmonary artery pressure ≥35 mmHg. Patients were followed until 4/2012 for exercise capacity, survival, and targeted therapy use.ResultsPatients with severe PH (n = 40) received significantly more often targeted therapy compared to the 32 patients with less severe PH (65% vs. 25%, P = 0.001). Survival was not significantly different between these groups (P = 0.310). Patients on targeted therapy were older, more often female, and had worse hemodynamic impairment, but significantly higher estimated 1‐, 3‐, and 5‐year survival rates compared to untreated patients (97%, 81%, and 75% vs. 83%, 54%, and 19%, respectively; P = 0.002). This effect was mainly driven by the patients with severe PH, in whom the survival advantage was statistically significant on subgroup analysis (HR 0.182, P = 0.002). Exercise capacity was not significantly altered in any patient group.ConclusionPatients with severe PH due to lung disease may have a survival benefit from targeted therapy compared to untreated patients with less severe PH. Prospective clinical trials utilizing targeted therapy and long‐term endpoints are justified in this patient group.
Prescribers' Practice of Assessing Arrhythmia Risk with QT‐Prolonging Medications
Authors: Choo Wai Kah , Turpie David , Milne Kim , Davidson Lynne , Elofuke Petrus , Whitfield Jonathan , Broadhurst Paul 
Published: June 2014

SummaryAimsThis study aimed to assess prescribers' monitoring for arrhythmic risk with QT‐prolonging medications (LQT drugs).MethodsOver a 6‐month period, all inpatients under the care of Cardiologists (Cohort A) and General Physicians (Cohort B) at Aberdeen Royal Infirmary who were prescribed drugs with known risk of Torsades de Pointes (TdP) were identified. Admission and repeat electrocardiograms (ECG) after 48 h of commencing a LQT drug were examined. Actions taken if QTc was prolonged and drug–drug interactions were examined. A risk estimate on the UK hospital population was calculated.ResultsOf the 4133 patients admitted during the study period, 234 (6%) patients were prescribed a LQT drug. There were 100 (43%) patients in Cohort A and 134 (57%) patients in Cohort B. Of those admitted with a pre‐existing LQT drug prescription, an ECG was performed in 167 (96%) of patients and QTc prolongation was identified in 59 (34%). Of those who received a new prescription of LQT drug, 23 (38%) had QTc prolongation and more patients in Cohort A than Cohort B had a repeat ECG within 48 h (84% vs. 11%, P < 0.0001). QTc prolongation was only recognized in 6 (14%) and 2 (5%) patients in cohorts A and B, respectively. Only one patient at risk of drug interaction had QTc prolongation. None of our patients had documented TdP in hospital. Extrapolating these findings to the UK hospital population, at least 204 and <17–175 patients on cardiac and noncardiac LQT drugs, respectively, might be expected to have TdP each year.ConclusionRecognition of acquired QTc prolongation is poor. Clinician education and an electronic prescribing system may improve this situation.
Incidental renal neoplasms: is there a need for routine screening? A Danish single‐center epidemiological study
Authors: Rabjerg Maj , Mikkelsen Minne Nedergaard , Walter Steen , Marcussen Niels 
Published: June 2014

On the basis of associations between tumor size, pathological stage, histological subtype and tumor grade in incidentally detected renal cell carcinoma vs symptomatic renal cell carcinoma, we discussed the need for a screening program of renal cell carcinoma in Denmark. We analyzed a consecutive series of 204 patients with renal tumors in 2011 and 2012. The tumors were classified according to detection mode: symptomatic and incidental and compared to pathological parameters. Eighty‐nine patients (44%) were symptomatic, 113 (55%) were incidental. Information was not available in two patients. In the incidental group, the size (p < 0.05), pathological stage (p < 0.001), Fuhrman grading (p < 0.0001) and Leibovich score (p < 0.0001) were lower than in those causing symptoms. Significantly less in the incidental group had metastasis at follow‐up (p < 0.0001). Incidentally discovered RCC constitute a major part of kidney tumors. They have a more favorable prognosis than symptomatic tumors and seem to be discovered in an earlier phase. Needle core biopsy is an accurate technique for distinguishing between malignant and benign tumors and is recommendable for smaller incidental tumors. Screening may help detect RCC at an earlier stage.