bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging Divides or Reinforcing Distance? The Interplay of Individual and Organizational Factors in Shaping Volunteers’ Relationships with Criminalized Women
Authors: Quinn Kaitlyn 
Published: July 2024

Abstract
As governments cut funding for social welfare programs and shift toward neoliberal, marketized alternatives, non-profits have taken on a large and growing role in the provision of services to marginalized people. This paper examines how volunteers approach their relationships with service users in non-profits, as well as the consequences of and explanations for variation in their approaches. This research explores these questions ethnographically within Canadian non-profits offering social services to criminalized women. This paper offers three interrelated contributions. The first is a typology of different volunteer approaches within the penal voluntary sector—constructing volunteers as bystanders, tourists, visitors, or apprentices in their relationships with criminalized women. The second highlights how some of these approaches entrench social distance and inequality, whereas others encourage greater proximity and equity between volunteers and criminalized women. The third demonstrates how variation in volunteers’ approaches is the product of a dynamic interplay of individual and organizational factors. Together, these findings provide new insights about the conditions under which volunteers can do “good” or “bad” within non-profits. These insights could enhance the quality of volunteer work, reduce the reproduction of inequalities, and support the operation of organizations delivering vital services to marginalized people.
Removal of historical taxonomic bias and its impact on biogeographic analyses: a case study of Neotropical tardigrade fauna
Authors: Ugarte Pedro Danel de Souza , Garraffoni André Rinaldo Senna 
Published: July 2024

Abstract
Large-scale databases are crucial for macroecology research, yet not entirely bias-free. Studying the biogeography of metazoan microfauna utilizing such databases is challenging, and added biases can further hinder them. Incidence data of tardigrade species from Central and South America are geographically biased, comprising mostly species erroneously considered cosmopolitan. The impact of these biases on macroecological studies is still unknown. This paper evaluates how biased distribution records affect understanding of non-marine tardigrade distribution patterns in the Neotropical region. Using two datasets (including and excluding dubious records of allegedly cosmopolitan species), we assess how well biogeographic regions are sampled, estimate tardigrade species’ richness, and analyse whether including dubious records can alter our comprehension of their macroecology. We demonstrate how biogeographic regions are still not fully sampled, and that including unreliable records influences how many species remain to be discovered. Since records of ‘false cosmopolitan species’ represent most records, their removal increases uncertainty while yielding distribution patterns more likely to be accurate. Disregarding untrustworthy distribution records of ‘false cosmopolitan species’ is the first step to better understanding tardigrade macroecology in the Neotropics, and probably worldwide. However, additional, preferably systematic sampling is required before we can infer general tardigrade biodiversity patterns in under-sampled regions.
Experimental Infection of California Ripe Olive Cultivars with Xylella fastidiosa Subspecies pauca De Donno and Acquisition by Glassy-Winged Sharpshooter
Authors: Burbank Lindsey , Rogers Elizabeth E. , Sechler Aaron J. , Magdeleno Mayra , Krugner Rodrigo 
Published: July 2024

Strains of Xylella fastidiosa subspecies pauca can infect olive trees, and an introduction of this pathogen has caused significant damage to the olive industry in Europe. Although this subspecies is not known to be present in North America, the environment, plant hosts, and insect vectors in the United States olive-growing regions (mainly California) are conducive to X. fastidiosa spread and disease damage. This study evaluated several risk factors for X. fastidiosa disease in the California olive industry, including infection of the common cultivars and acquisition by insect vectors. Olive cultivars Manzanillo, Sevillano, and Mission all exhibited disease symptoms after inoculation with X. fastidiosa strain De Donno obtained from the olive disease outbreak in southern Italy. Glassy-winged sharpshooters were able to acquire X. fastidiosa De Donno from infected olive plants as soon as 30 days after plant inoculation. This information is valuable for risk assessment and disease management planning in the event of a future introduction of olive-pathogenic strains of X. fastidiosa to the United States. [Formula: see text] The author(s) have dedicated the work to the public domain under the Creative Commons CC0 “No Rights Reserved” license by waiving all of his or her rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law, 2024.
Implementation of a Mental Health Objective Structured Clinical Examination (OSCE) Using Standards of Best Practice
Authors: Stockmann Cherrill , Adelman-Mullally Theresa , Willett Joanna , Dyck Mary J. 
Published: July 2024

Abstract
The objective structured clinical examination (OSCE) is effective for the evaluation of clinical competence. Studies examining the use of OSCEs in undergraduate mental health nursing education in the United States are limited. A pilot study and a follow-up study were conducted to establish the reliability and validity of a mental health OSCE to evaluate the clinical competence of prelicensure nursing students. International Nursing Association for Clinical Simulation and Learning Standards of Best Practice were used to guide the design and implementation. Results from both studies provide evidence for the use of OSCE in undergraduate mental health nursing education.
Preoperative Bilateral External Oblique Intercostal Plus Rectus Sheath Block for Postoperative Pain Management Following Laparoscopic Cholecystectomy
Authors: Mo Ke , Kong Weirong , Chen Jiaxin , Zhao Shuhua , Zhu Qianqian 
Published: July 2024

Objectives:
The transversus abdominis plane (TAP) block has proven efficacy and is an important component of multimodal analgesia in laparoscopic cholecystectomy (LC). The external oblique intercostal (EOI) block can provide a dermatomal sensory blockade of T6 to T10 using an anterior axillary line injection. The bilateral rectus sheath (RS) block can significantly reduce early postoperative pain caused by umbilical or periumbilical incisions. The current study aimed to compare the analgesic efficacies of ultrasound-guided subcostal TAP (UG-TAP) combined with the RS block and ultrasound-guided EOI (UG-EOI) combined with the RS block for LC.

Methods:
Patients were randomly assigned to TAP or EOI group. Patients in TAP group received UG-TAP combined with an RS block. Patients in EOI group received UG-EOI combined with an RS block. The primary outcome was postoperative 24-hour sufentanil consumption.

Results:
A total of 49 patients were included in the final analysis. The postoperative 24-hour sufentanil consumption in the EOI group was significantly lower than that in the TAP group (9.79±10.22 vs. 18.67±12.58 µg; P [noninferiority] <0.01; noninferiority confirmed). Fewer patients in the EOI versus TAP group had a numerical rating score of >3 during motion. Furthermore, the mean postoperative 48-hour sufentanil consumption was lower in the EOI versus TAP group (11.54±11.70 vs. 23.04±17.10 µg; P=0.01). The mean postoperative 24-hour Quality of Recovery-15 score was higher in the EOI versus TAP group (135.21±4.40 vs. 131.91±5.11; P=0.02).

Discussion:
These findings suggest that UG-EOI combined with an RS block was superior to UG-TAP combined with an RS block for postoperative pain management in patients undergoing LC.
Impact of Spinal Deformity and Surgery on Health-Related Quality of Life in Cerebral Palsy: A Multicenter Prospective Controlled Trial
Authors: Cahill Patrick J. , Narayanan Unni , Bowen Margaret , Sarkar Sulagna , Pahys Joshua M. , Miyanji Firoz , Yaszay Burt , Shah Suken A. ,   Harms Study Group, Sponseller Paul D. 
Published: July 2024

Background:
Spinal fusion for scoliosis associated with cerebral palsy (CP) is challenging to study because specialized outcome measures are needed. Therefore, evidence in favor of the benefits of surgery has not been firmly established. This study aimed to determine if corrective spinal fusion improves health-related quality of life (HRQoL) in children with CP scoliosis at 2 years.

Methods:
Children with CP and scoliosis who met the criteria for posterior spinal fusion were offered enrollment at 16 US and Canada centers. Participants’ families selected either operative intervention (OP) or nonoperative treatment (NON) in discussion with their surgeon with no influence by the decision to participate in the research study. Demographic, clinical data (function level, magnitude of deformity, comorbidities), and HRQoL (CPCHILD Questionnaire) were collected at baseline and 2 years. Change (from baseline) in total CPCHIL scores was the primary outcome.

Results:
Three hundred one OP and 34 NON subjects had complete baseline and 2-year data. At baseline, both groups were comparable in function level, comorbid status, and CPCHILD scores (52.1 ±15.3 vs. 53.4 ±14.5; P=0.66). The OP group had a larger spinal deformity magnitude (84.5˚ ± 21.8˚ vs. 66.3˚ ± 18.1˚) (P=0.001). The total CPCHILD score improved in the OP group by 6.6 points (P<0.001). NON scores were unchanged (+1.2; P=0.65) during follow-up. There were also significant score increases in the OP group for 5 of 6 CPCHILD domains. The change in CPCHILD scores from enrollment to 2 years was more significant in the OP group (P=0.05).

Conclusion:
For children with CP who undergo spinal fusion, HRQoL improved over preoperative levels and an unchanged nonoperative control group.

Level of Evidence:
Level II.
Pelvic Incidence As a Predictor of Proximal Junctional Kyphosis in Patients with Lenke type 5 Adolescent Idiopathic Scoliosis
Authors: Kitagawa Takahiro , Suzuki Satoshi , Takeda Kazuki , Okubo Toshiki , Ozaki Masahiro , Takahashi Yohei , Tsuji Osahiko , Nagoshi Narihito , Yagi Mitsuru , Matsumoto Morio , Nakamura Masaya , Watanabe Kota 
Published: July 2024

Study Design.
Retrospective comparative study.

Objective.
To evaluate the relationship between pelvic incidence (PI) and proximal junctional kyphosis (PJK) in patients with Lenke type 5 adolescent idiopathic scoliosis (AIS).

Summary of Background Data.
Although PJK is a common complication of sagittal malalignment after posterior correction and fusion surgery (PSF), few studies have assessed its risk factors. The significance of pelvic morphology in relation to PJK has been suggested but remains unclear in Lenke type 5 AIS patients.

Methods.
A total of 92 patients with Lenke type 5 AIS who underwent selective thoracolumbar PSF with a minimum follow-up of two years were included. Patients were divided into PJK and non-PJK groups based on postoperative radiographs. The influence of PI on PJK occurrence was evaluated through binary logistic analysis. Subgroup analysis was performed based on the PI value (low PI,<45°; high PI, ≥ 45°) to identify factors affecting PJK occurrence.

Results.
PJK was observed in 17.4% of the whole cohort. Binary logistic regression analysis identified low PI and large TL/L curve as a risk factor for PJK (PI, odds ratio, 0.933; TL/L curve, odds ratio, 1.080). Subgroup analysis showed that the postoperative increase in the upper instrumented vertebra slope in PJK cases was comparable in both the low and high PI groups. Meanwhile, lordotic changes in the fused area in the PJK cases were observed only in the low PI group. No difference in the Scoliosis Research Society 22 scores were observed between the two groups.

Conclusion.
From this study a low PI was identified as a risk factor for the occurrence of PJK in Lenke type 5 AIS patients. The occurrence of PJK is influenced by lordotic changes in the fused area and the limited compensatory capacity of the pelvis in patients with a low PI.
Association and its population heterogeneities between low-density lipoprotein cholesterol and all-cause and cardiovascular mortality: A population-based cohort study
Authors: Lu Jiapeng , Zhang Haibo , Chen Bowang , Yang Yang , Cui Jianlan , Xu Wei , Song Lijuan , Yang Hao , He Wenyan , Zhang Yan , Peng Wenyao , Li Xi 
Published: July 2024

Abstract

Background:
The association and its population heterogeneities between low-density lipoprotein cholesterol (LDL-C) and all-cause and cardiovascular mortality remain unknown. We aimed to examine the dose-dependent associations of LDL-C levels with specific types of cardiovascular disease (CVD) mortality and heterogeneities in the associations among different population subgroups.

Methods:
A total of 2,968,462 participants aged 35–75 years from China Health Evaluation And risk Reduction through nationwide Teamwork (ChinaHEART) (2014–2019) were included. Cox proportional hazard models and Fine–Gray subdistribution hazard models were used to estimate associations between LDL-C categories (<70.0, 70.0–99.9, 100.0–129.9 [reference group], 130.0–159.9, 160.0–189.9, and ≥190.0 mg/dL) and all-cause and cause-specific mortality.

Results:
During a median follow-up of 3.7 years, 57,391 and 23,241 deaths from all-cause and overall CVD were documented. We observed J-shaped associations between LDL-C and death from all-cause, overall CVD, coronary heart disease (CHD), and ischemic stroke, and an L-shaped association between LDL-C and hemorrhagic stroke (HS) mortality (P for non-linearity <0.001). Compared with the reference group (100.0–129.9 mg/dL), very low LDL-C levels (<70.0 mg/dL) were significantly associated with increased risk of overall CVD (hazard ratio [HR]: 1.10, 95% confidence interval [CI]: 1.06–1.14) and HS mortality (HR: 1.37, 95% CI: 1.29–1.45). Very high LDL-C levels (≥190.0 mg/dL) were associated with increased risk of overall CVD (HR: 1.51, 95% CI: 1.40–1.62) and CHD mortality (HR: 2.08, 95% CI: 1.92–2.24). The stronger associations of very low LDL-C with risk of CVD mortality were observed in individuals with older age, low or normal body mass index, low or moderate 10-year atherosclerotic CVD risk, and those without diagnosed CVD or taking statins. Stronger associations between very high LDL-C levels and all-cause and CVD mortality were observed in younger people.

Conclusions:
People with very low LDL-C had a higher risk of all-cause, CVD, and HS mortality; those with very high LDL-C had a higher risk of all-cause, CVD, and CHD mortality. On the basis of our findings, comprehensive health assessment is needed to evaluate cardiovascular risk and implement appropriate lipid-lowering therapy for people with very low LDL-C.
Bioinformatics tools and resources for cancer and application
Authors: Huang Jin , Mao Lingzi , Lei Qian , Guo An-Yuan 
Published: July 2024

Abstract
Tumor bioinformatics plays an important role in cancer research and precision medicine. The primary focus of traditional cancer research has been molecular and clinical studies of a number of fundamental pathways and genes. In recent years, driven by breakthroughs in high-throughput technologies, large-scale cancer omics data have accumulated rapidly. How to effectively utilize and share these data is particularly important. To address this crucial task, many computational tools and databases have been developed over the past few years. To help researchers quickly learn and understand the functions of these tools, in this review, we summarize publicly available bioinformatics tools and resources for pan-cancer multi-omics analysis, regulatory analysis of tumorigenesis, tumor treatment and prognosis, immune infiltration analysis, immune repertoire analysis, cancer driver gene and driver mutation analysis, and cancer single-cell analysis, which may further help researchers find more suitable tools for their research.
Robot-assisted laparoscopic retroperitoneal lymph node dissection in testicular cancer using a single-position supine approach: A case report and literature review
Authors: Zhou Lei , Yao Kun , Li Chao , Xiong Wei , Hou Weibin , Wang Bingzhi , Xu Long , Wang Long 
Published: July 2024

Abstract
This case study demonstrates a single-position supine approach for robotic retroperitoneal lymph node dissection for the treatment of nonseminomatous germ cell tumors and residual masses after chemotherapy. We performed a bilateral robotic retroperitoneal lymph node dissection in a 33-year-old man with nonseminomatous germ cell tumors and residual postchemotherapy masses. For this approach, the patient was placed in a steep Trendelenburg position, and a 5-port transperitoneal technique was used, with the robot docked so that the arms were oriented cephalad. This approach allowed simultaneous access to both sides of the retroperitoneum, thereby eliminating the need for bilateral lymphadenectomy and patient repositioning. Bilateral R-RPLDN was performed using a single-position supine approach. This versatile approach offers a less invasive, more efficient, and safer solution for removing residual postchemotherapy testicular cancer masses.
Association of the dopamine D2 receptor gene SNP rs1800497 with postoperative nausea and vomiting
Authors: Stegen Maike , Bachmann Hagen S. , Belani Grazina , Mohamed Ahmed , Breuing Björn , Brenner Thorsten , Klenke Stefanie 
Published: July 2024

BACKGROUND
Postoperative nausea and vomiting (PONV) are the most frequent complications in the context of anaesthesia. Several studies suggest a contribution of genetic traits to PONV disposition. Single nucleotide polymorphisms (SNPs) located in the cholinergic receptor muscarinic 3 gene CHRM3 (rs2165870) and the potassium voltage-gated channel subfamily B member 2 KCNB2 (rs349358) have been described as independent risk factors for the occurrence of PONV. In addition, further SNPs might be associated with an increased PONV risk, for example a dopamine D2 receptor (DRD2) SNP (rs1800497).

OBJECTIVE
The primary aim of our study was the development of a new PONV prediction score which includes genetic information of SNPs in the genes CHRM3 and KCNB2, which have been already associated with PONV. The secondary aim of our study was to investigate the association of five additional SNPs with PONV.

DESIGN
Prospective cohort study.

SETTING
Single centre study in Germany.

RESULTS
We could not establish a new PONV prediction score that includes genetic information, due to limited association of the KCNB2 SNP and CHRM3 SNP with PONV. Interestingly, the GA and AA genotypes of the DRD2 rs1800497 in the dopamine D2 receptor gene were associated with PONV 24 h postoperatively, with a relative risk (RR) of GA/AA genotype vs. GG genotype of 1.5 [95% confidence interval (CI) 1.06 to 2.01, P = 0.02]. This association was independent from the Apfel score in a multivariate logistic regression analysis (RR 1.4, 95% CI 1.03 to 1.90, P = 0.03).

CONCLUSION
The construction of a new PONV prediction score including genetic information was not possible due to limited association of the CHRM3 and KCNB2 SNPs. However, the DRD2 GA and AA genotypes (rs1800497) were associated with PONV and this SNP might be a future candidate for further validation studies aiming for molecular-derived PONV prediction models.

TRIAL REGISTRATION
German Clinical Study Register – DRKS00021051.
The degree of respiratory depression according to the effect-site concentration in remimazolam target-controlled infusion
Authors: Park Soo Jung , Min Sang Kee , Choi Gyubin , Kim Ji Eun , Kim Ha Yeon 
Published: July 2024

BACKGROUND
Remimazolam is not only associated with a lower incidence of respiratory depression than propofol but also in itself has the risk of respiratory depression.

OBJECTIVE
We investigated respiratory depression following remimazolam infusion, targeting different effect-site concentrations using target-controlled infusion.

DESIGN
A prospective, double-blind, randomised controlled study.

SETTING
Tertiary hospital, Suwon, South Korea, from April 2022 to November 2022.

PARTICIPANTS
One hundred and seven patients scheduled for general anaesthesia were randomised into three groups targeting remimazolam effect-site concentrations of 500 (RMZ-500) (n = 36), 1000 (RMZ-1000) (n = 35) and 1500 ng ml−1 (RMZ-1500) (n = 36).

INTERVENTIONS
Remimazolam was solely infused for 10 min according to target effect-site concentrations. According to the degree of SpO2 decrease, oxygen desaturations were managed with the following respiratory supports: jaw-thrust for SpO2 less than 97%, 100% oxygen delivery for SpO2 less than 93% and assisted ventilation for SpO2 less than 90%.

MAIN OUTCOME MEASURES
The incidence of each respiratory support, along with respiratory variables (at baseline, 5 min and 10 min after remimazolam infusion) and loss of consciousness were observed for 10 min after remimazolam target-controlled infusion.

RESULTS
Both RMZ-1000 and RMZ-1500 required more frequent respiratory support than RMZ-500 (both P < 0.001), with nearly identical frequencies between RMZ-1000 and RMZ-1500. In terms of respiratory support, the incidence of assisted ventilation was significantly lower in RMZ-500 (2.8%) than RMZ-1000 (48.6%) and RMZ-1500 (50%) (P < 0.001). RMZ-1000 and RMZ-1500 achieved loss of consciousness in all patients; RMZ-500 only achieved loss of consciousness in 86.1% of patients (P = 0.010). In patients who maintained spontaneous respiration, tidal volume decreased by 41 to 48% and respiratory rate increased by 118 to 158% at 5 and 10 min, significantly compared to baseline in all groups (P < 0.001).

CONCLUSIONS
Remimazolam infusion, like that of other benzodiazepines, led to respiratory depression, which was more prominent at higher target effect-site concentrations. Therefore, appropriate countermeasures should be developed to prevent oxygen desaturation.

TRIAL REGISTRATION
CRIS (https://cris.nih.go.kr), identifier: KCT0006952
Intravenous lidocaine for postoperative analgesia management in paediatrics
Authors: Pardessus Pierre , Loiselle Maud , Brouns Kelly , Horlin Anne-Laure , Bruneau Beatrice , Maroun Yara , Lagarde Martin , Deliere Maxime , Julien-Marsollier Florence , Dahmani Souhayl 
Published: July 2024

BACKGROUND
The administration of intravenous lidocaine during the peri-operative period may improve pain management after paediatric surgery.

OBJECTIVE
To explore the decrease in postoperative pain intensity and opioid consumption associated with peri-operative lidocaine administration in the paediatric population.

DESIGN
A systematic review with meta-analysis of randomised controlled trials and a Grading of Recommendations Assessment, Development and Evaluation (GRADE) analysis.

DATA SOURCES
Extensive literature review.

ELIGIBILITY CRITERIA
This study includes clinical trials conducted during surgery that examined the effect of intravenous lidocaine compared with placebo on postoperative pain management.

RESULTS
Lidocaine administration decreased pain intensity in PACU (standardised mean difference (SMD) = -1.89 [-3.75, -0.03], I
2 = 97%, P of I
2 < 0.001) and on postoperative day 1 (SMD = -2.02 [-3.37, -0.66], I
2 = 96%, P of I
2 < 0.001, number of studies = 5). Lidocaine was associated with a decrease in opioid consumption on postoperative day 1 (SMD = -1.2 [-2.19, -0.2], I
2 = 93%, P of I
2 < 0.001) but not on postoperative day 2 (SMD = -1.73 [-3.9, 0.44], I
2 = 96%, P of I
2 < 0.001). GRADE analyses resulted in low-quality results. Subgroup analyses revealed that pain intensity in PACU and opioid consumption on postoperative day 1 decreased when lidocaine was administered during both the intra-operative and postoperative periods.

CONCLUSIONS
The use of lidocaine is associated with improved pain management. However, further studies are needed to increase the level of evidence and determine the optimal administration regimen for pain management.