bluuebunny/crossref_metadata_2025_split huggingface dataset:
The PENGARUH MEDIA BOOKLET TERHADAP MOTIVASI BELAJAR SISWA DI SMP NEGERI 3 KOTA KUPANG TAHUN AJARAN 2019/2020 (INFLUENCE OF BOOKLET AS AN INSTRUCTIONAL MEDIA TOWARD STUDENTS’ LEARNING MOTIVATION IN SMP NEGERI 3 KUPANG ACADEMIC YEAR 2019/2020)
Authors: Nomleni Fransina Thersiana 
Published: February 2025

Abstrak
Tujuan dari penelitian ini untuk mengetahui pengaruh media pembelajaran berbentuk booklet terhadap motivasi belajar siswa di SMP Negeri 3 Kupang tahun ajaran 2019/2020. Penelitian ini merupakan penelitian eksperimen dengan metode post-test only control group desain, dengan jumlah populasi sebanyak 144 dan jumlah sampel dua kelas yang terdiri dari 30 siswa kelas VIIIF (kelas eksperimen) dan 30 siswa kelas VIIIG kelas (kontrol). Pengambilan sampel yang digunakan adalah random sampling. Pengumpulan data menggunakan angket. Data dianalisis menggunakan uji-t. Hasil penelitian menunjukan bahwa terdapat yang signifikan dari penggunaan media booklet terhadap motivasi belajar siswa dengan perolehan nilai t sebesar 12, 783 dengan sig. 0,000 atau lebih kecil dari 0,5. Hal ini dikarenakan media booklet memiliki beberapa kelebihan, yakni ukurannya lebih kecil sehingga siswa dapat membawanya kemana-mana. Selain itu, media booklet tersusun dari gambar-gambar yang menarik dan konsep materinya disajikan berdasarkan dengan permasalahan pembelajaran yang terdapat dilingkungan sekitar siswa sehingga medorong keingintahuan siswa dan menarik perhatian siswa untuk aktif dan bersemangat dalam belajar serta membantu siswa dalam memahami materi pembelajaran secara verbal dan visual berdasarkan hal-hal kongkrit yang sering siswa temui. Berdasarkan hal ini, maka dapat disimpulkan ada pengaruh penggunaan media booklet terhadap motivasi belajar siswa di SMP Negeri 3 Kota Kupang.

Kata kunci: Media Pembelajaran, Media booklet, Motivasi Belajar

Abstract
The authors investigate the influence of booklet as an instructional media toward students’ learning motivation in SMP Negeri 3 Kupang academic year 2019/2020. The experiment research applied in this paper specifically focuses on using posttest design only for the control group. The population of the research consists of 144 students. Two groups of classes were taken as sample in this paper; they are 30 grade VIII F students (experiment group) and 30 grade VIII G students (control group). The random sampling technique used to identify the sample. The questionnaire was used to collect the data, and it analyzed using t-test. There was a significant improvement on students’ learning motivation through booklet where the T score was 12,783 with sig. 0,000 smaller than 0, 5. The booklet has same streng thens as it handy, colorful, and up to date. Moreover, as the materials were design perfectly, students enjoyed and actively involved in every class meeting. Therefore, it can be concluded that there was a significant improvement on students’ learning motivation using booklet as an instructional media.

Key words: instructional media, booklet, learning motivation.
RELASI KERJA MANDOR DENGAN BURUH PEMETIK TEH (Kasus di PT. Perkebunan Sarana Mandiri Mukti, Kecamatan Kabawetan Kabupaten Kepahiang)
Authors: Sanjaya Budiman , Arwani Muhammad Marwan , Hanum Sri Handayani 
Published: February 2025

Penelitian ini bertujuan untuk mengetahui bagaimana relasi kerja antara mandor dengan buruh pemetik teh yang asimetris di PT Perkebunan Sarana Mandiri Mukti di Kecamatan Kabawetan Kabupaten Kepahiang. Metode yang digunakan adalah kualitatif. Dengan menggunakan teknik penentuan informan Snowball Sampling yaitu cara penentuan informan dengan jumlah sampel tidak ditentukan, ketika data yang diberikan informan inti maupun informan tambahan sudah dianggap lengkap maka proses pencarian data dihentikan.Informan inti adalah mandor dan buruh pemetik teh serta informan tambahan yaitu mandor besar. Teori yang dipergunakan adalah teori kesadaran kelas semu yang memunculkan hubungan kerja yang asimetris, penulis menggunakan teori kesadaran kelas semu untuk menganalisis lebih mendalam mengenai relasi kerja yang terjalin antara mandor dengan buruh pemetik teh. Subjek dalam penelitian ini adalah para mandor dan buruh pemetik teh. Informan dalam penelitian ini adalah orang-orang yang juga bekerja di perkebunan teh Kabawetan yang memiliki informasi pendukung untuk menguatkan data penelitian. Hasil penelitian menunjukkan bahwa (1) Hubungan kerja yang terjalin antara mandor dan buruh pemetik teh merupakan hubungan kerja yang asimetris atau hubungan yang tidak seimbang. Hubungan kerja yang asimetris (tidak seimbang) itu dapat dilihat dari pola kerja mandor yang lebih ringan dibandingkan dengan pola kerja buruh, akan tetapi upah yang diperoleh mandor justru lebihbesar dibandingkan dengan upah yang diterima oleh buruh pemetik teh, selain itu hubungan asimetris antara mandor dan buruh pemetik teh dapat dilihat dariperlakuan mandor dari perjanjian kerja, pengawasan kerja hingga aktivitas kerja yang membeda-bedakan atau bersikap tidak adil terhadap buruhyang sudah tua dengan buruh pemetik yang masih muda, (2) Hubungan kerja yangasimetris antara mandor dan buruh pemetik teh menimbulkan suatu ketidakadilanbagi buruh pemetik teh, ketidakadilan yang diterima buruh pemetik menciptakansebuah kesadaran kelas semu pada buruh pemetik teh, artinya buruh pemetikmenyadari bahwa keadaan ekonomi yang sulit dan keterbatasan keahlian hidupyang dimiliki, membuat buruh pemetik teh tetap bertahan menjadi seorang buruhpemetik teh yang berada dalam suatu relasi kerja yang asimetris yang terjalindengan mandor. Kata Kunci: Relasi Kerja Asimetris, Mandor, dan Buruh Pemetik Teh
Prevalence of intraoperative complications with open sinus lift and underwood septa
Authors: Gahri D. , Huseynov N. A. , Ivanov S. S. , Ivanov S. Y. 
Published: February 2025

The loss of maxillary masticatory teeth is associated with a decrease in both the height and width of the alveolar bone mass. In addition to the bone limits, implant placement to replace the missing tooth is complicated by the close proximity of the maxillary sinus floor. The above can negatively affect the success of the patient’s surgical rehabilitation. The maxillary sinus lift (MS), or sinus lift, can optimize the procedure and the results of dental implantation. Maxillary sinus floor lift surgery is a procedure with predictable results and a low complication rate, with an expected success rate of over 90 % in the long term. However, like any surgical procedure, a sinus lift comes with some complications. One of the most common complications is Schneider’s membrane perforation, which occurs either for iatrogenic reasons related to improper surgical actions or due to anatomical features of a particular patient that may complicate the procedure. A particularly interesting fact is the association of the incidence of MS membrane perforation with individual patient anatomy, particularly the presence of frontal or sagittal bony septa. The purpose of this study is to determine the relationship of the incidence of Schneider’s membrane perforation during sinus lift surgery in patients with and without bony septa in the MS. Materials and Methods. The present study included 100 patients who underwent open sinus lift surgery with subsequent implant placement. The participants were divided into 2 groups after studying the data of preoperative CBCT: group 1 – patients without septum in the MS (control group – 30 patients), group 2 – patients with septum in the MS (experimental group – 70 patients). Postoperative follow-up of the patients of both groups to monitor the presence of complications from Schneider’s membrane was performed on the 3rd,5th,7th day according to clinical symptoms. Results. For group 1 patients (MS without septum), the rate of Schneider’s membrane perforation during sinus lift was 20 %, whereas for group 2 patients (MS with septum), the rate of perforation was 77.2 %. Conclusions. The obtained data indicate a higher incidence of Schneider membrane damage during open sinus lift surgery in patients with individual anatomical features of the MS compared to patients with classic MS anatomy. The above-mentioned necessitates a more thorough preoperative planning of the invasive intervention, as well as a detailed analysis of 3D radiographs (CBCT) of the maxillary sinus.
The usage of pharmacopuncture in medical complexes for lumbosacral dorsopathies
Authors: Agasarov L. G. 
Published: February 2025

The material is devoted to the results of a number of own studies in the field of local drug stimulation (pharmacopuncture) – a technique for irritating reflexology points with small doses of drugs. In this respect, the topic being developed fits well into the general course of the problem of low-energy therapeutic effects, interest in which has only increased recently. In the mechanisms of technology, the role of prolongation of the reflex response and the formation of the depot of the drug used is distinguished. However, the issues of summation and, moreover, potentiation of these influences remain unclear, which determined the implementation of a series of works. The object of observation was lumbosacral dorsopathy, since the bulk of research on local stimulation is devoted to the correction of these conditions. Naturally, the enduring medical, social and economic significance of the problem of dorsopathies was taken into account. In the work performed, the mechanisms and effectiveness of pharmacopuncture with Alflutop, shown in the pathology under study, were analyzed. The evaluation of the effectiveness of the method included in the complex therapy programs was based on taking into account the dynamics of clinical and additional (psychological, electrophysiological) characteristics of the patient’s condition. At the same time, the addition of the reflex and drug links of the method was confirmed, which determines its significant superiority over the compared methods. In this regard, the structural-modifying effect in the form of shifts in the state of the intervertebral discs, observed in the course of the combined application of the selected technology and electromagnetic stimulation, was of fundamental importance. In addition, within the framework of the affected direction, an effective scheme of exposure was proposed, combining the techniques of drug blockade according to the method of A.V. Vishnevsky and pharmacopuncture with Alflutop.
Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential
Authors: Bulletti Francesco M. , Sciorio Romualdo , Conforti Alessandro , De Luca Roberto , Bulletti Carlo , Palagiano Antonio , Berrettini Marco , Scaravelli Giulia , Pierson Roger A. 
Published: February 2025

IntroductionInfertility is characterized by the failure to conceive after 12 months of unprotected sexual intercourse. In assisted reproduction technologies (ARTs), in-vitro fertilization and embryo transfer (IVF-ET) are pivotal, with the quality of embryo quality essential for successful implantation.ObjectiveThis systematic review with meta-analysis aimed to explore the prevalence of embryonic factors involved in the implantation process, concentrating on the following research inquiries: 1) the implantation rates of euploid versus untested embryo transfers; 2) the efficiency of transferring good embryos in different age groups; 3) the impact of age on good embryo transfers to gestational carriers; and 4) the transfer of donated gametes/embryos. The goal is to identify critical points in implantation to improve therapies.MethodsA comprehensive literature search identified 1474 relevant papers, 11 of which met the inclusion criteria. The information was gathered using a standardized form, and the risk of bias was evaluated. A meta-analysis of subgroups to determine euploid embryo transfer efficiency was conducted to synthesize and explore the results. Furthermore, data extracted from registries document the persistent secondary role of extraembryonic determinants in successful implantation.ResultsThe meta-analysis demonstrated that preimplantation genetic testing for aneuploidy (PGT-A) significantly increased the odds of implantation. Age was found to influence extraembryonic factors, with older women experiencing reduced embryo implantation as gestational carriers. However, the overall incidence of extraembryonic factors was low. This review highlights the need to focus on PGT-A, diagnostic hysteroscopy, and endometrial receptivity for improving implantation rates.ConclusionImplantation success in ARTs largely depends on embryo euploidy. While achieving three euploid embryos greatly increases success rates, it is challenging in older women. Extraembryonic factors, although present, have a marginal impact. Subsequent studies ought to concentrate on modulating endometrial responses immunologically and developing algorithms to improve the precision of predicting implantation success; as well as the timing of endometrial receptivity and the occurrence of dormant embryo phenomena also warrants further investigation.
Case report: Long-term survival in synchronous double primary malignancies of lung adenocarcinomas and esophageal squamous cell carcinoma treated with definitive chemoradiotherapy and SBRT combined with anti-PD-1
Authors: Zeng Rui , Zhou Xiaoyun , Ou Kexin , Chen Wei , Yang Chen , Wang Ting , Li Yani , Zha Yawen , Li Minying , Zhang Jingjing 
Published: February 2025

BackgroundThe occurrence of multiple primary cancers has become common, and the treatment of such patients is very complex, so it is necessary to combine a variety of individualized treatment methods to achieve better treatment results.Case descriptionThis report describes a patient with double primary tumors of lung and esophageal cancer had more than 36 months survival with non-operation treatment. The patient diagnosed as lung adenocarcinomas (LADC) and esophageal squamous cell carcinoma (ESCC), was treated with albumin-bound paclitaxel, nedaplatin, and anti-programmed death 1 (anti-PD-1). The esophageal lesions achieved complete response (CR) after finishing two courses of induction chemotherapy combined with anti-PD-1 followed by definitive chemoradiotherapy (CRT). Radiation pneumonitis (RP) occurred one month after the completion of CRT. The pneumonia was relieved after dexamethasone and moxifloxacin treatment. Then, the lung lesion was treated with oral chemotherapy followed by stereotactic body radiation therapy (SBRT). As of July 2024, the patient has survived for more than 3 years after the above treatments, and the current efficacy evaluation is CR of esophageal lesions, PR of pulmonary lesions.ConclusionThe multi-modality approach of systemic therapy combined with localized radiotherapy is an effective treatment in the patients of the double primary malignant tumors of LADC and ESCC. The safety and toxicity of radiotherapy for the thoracic double primary tumors demonstrate acceptability.
Gruberi bursitis in rheumatic patients with foot and ankle pain: a retrospective sonographic study
Authors: Todorov Plamen , Mekenyan Lili , Levterova Boryana , Batalov Anastas 
Published: February 2025

IntroductionFoot and ankle pain is a common problem in rheumatic patients. One often underrecognized cause of this complaint is Gruberi (or subtalar) bursitis. The Gruberi bursa is a structure that originates from the sinus tarsi and extends over the dorsal talar surface. It reduces the friction of the extensor digitorum longus tendon over the convex contour of the head of the talus. On ultrasound, Gruberi bursitis is characterized by a well-defined fluid collection in the dorsolateral foot, located between the talus and the tendon of the extensor digitorum longus. Our study aimed to determine the frequency of Gruberi bursitis in patients with various rheumatic diseases who presented with foot and ankle pain at our institution and to describe its sonographic features in detail.Materials and methodsA descriptive, observational, retrospective study was conducted on patients over 18 years old who visited a tertiary university hospital between 1 July 2022 and 31 December 2023. Details regarding the patients’ medical history, age, gender, and primary rheumatic disease were obtained from their medical records. Descriptive statistics were utilized to present the data.ResultsOf the 608 patients examined for foot and ankle pain at our institution during the study period, 78 cases of Gruberi bursitis were identified in 63 patients. The average age of the participants was 61.7 years (range: 25–85 years), and 71% (n = 45) of the participants were women. The sonographic features of Gruberi bursitis included a monocular, anechoic fluid collection typically located between the extensor digitorum longus tendon and the dorsolateral surface of the head of the talus. The mean largest dimension of fluid collections in the oblique plane (from the sinus tarsi and across the dorsal talus) was 16 mm (range: 8–29 mm).ConclusionGruberi bursitis is easily identifiable through ultrasound due to its characteristic location and appearance. In total, we identified this condition in 9% of our rheumatic patients with foot and ankle pain.
A CRISPR-Cas-based recombinase polymerase amplification assay for ultra-sensitive detection of active Trypanosoma brucei evansi infections
Authors: Álvarez-Rodríguez Andrés , Li Zeng , Jin Bo-Kyung , Stijlemans Benoit , Geldhof Peter , Magez Stefan 
Published: February 2025

IntroductionControl of Trypanosoma brucei evansi (T. b. evansi) infections remains a significant challenge in managing Surra, a widespread veterinary disease affecting both wild and domestic animals. In the absence of an effective vaccine, accurate diagnosis followed by treatment is crucial for successful disease management. However, existing diagnostic methods often fail to detect active infections, particularly in field conditions. Recent advancements in CRISPR-Cas technology, combined with state-of-the-art isothermal amplification assays, offer a promising solution. This approach has led us to the development of a TevRPA-CRISPR assay, a highly sensitive and specific T. b. evansi diagnostic tool suitable for both laboratory and field settings.MethodsFirst, the TevCRISPR-Cas12b cleavage assay was developed and optimized, and its analytical sensitivity was evaluated. Next, this technology was integrated with the TevRPA to create the TevRPA-CRISPR test, with the reaction conditions being optimized and its analytical sensitivity and specificity assessed. Finally, the test’s accuracy in detecting both active and cured T. b. evansi infections was evaluated.ResultsThe optimized TevCRISPR-Cas12b cleavage assay demonstrated the ability to detect T. b. evansi target DNA at picomolar concentrations. Integrating TevCRISPR-Cas12b with RPA in Two-Pot and One-Pot TevRPA-CRISPR tests achieved up to a 100-fold increase in analytical sensitivity over RPA alone, detecting attomolar concentrations of T. b. evansi target DNA, while maintaining analytical specificity for T. b. evansi. Both assays exhibited performance comparable to the gold standard TevPCR in experimental mouse infections, validating their effectiveness for detecting active infections and assessing treatment efficacy.DiscussionThe TevRPA-CRISPR tests prove highly effective for diagnosing active infections and assessing treatment efficacy, while being adaptable for both laboratory and field use. Thus, the TevRPA-CRISPR assays emerge as a promising addition to current diagnostic tools, offering efficient and reliable detection of active T. b. evansi infections.
Delirium following mechanical thrombectomy for ischemic stroke – individuals at risk, imaging biomarkers and prognosis
Authors: Hahn Marianne , Brockstedt Lavinia , Gröschel Sonja , Geschke Katharina , Grauhan Nils F. , Brockmann Marc A. , Othman Ahmed E. , Gröschel Klaus , Uphaus Timo 
Published: February 2025

AimPost-stroke-delirium has been linked to worse outcome in patients with acute cerebrovascular disease; identification of individuals at risk may prevent delirium and thereby improve outcome. We investigate prognosis and factors associated with post-stroke-delirium in patients with large vessel occlusion (LVO) ischemic stroke treated by mechanical thrombectomy (MT).Methods747 patients (53.4% female) prospectively enrolled in the Gutenberg-Stroke-Study from May 2018–November 2022 were analyzed with regard to diagnosis of delirium. Group comparison of patient-, stroke- and treatment characteristics as well as computed tomography(CT)-imaging based parameters of cerebral atrophy (global cortical atrophy [GCA], posterior atrophy [Koedam], medial temporal lobe atrophy [MTA] scores) and white matter lesions (Fazekas score) was conducted. Independent predictors of delirium and the association of delirium with functional outcome at 90-day follow-up was investigated by multiple logistic regression analyses.ResultsWe report 8.2% of patients (61/747) developing delirium following MT of LVO. Independent predictors were older age (aOR[95%CI] per year: 1.034[1.005–1.065], p = 0.023), male sex (aOR[95%CI]: 2.173[1.182–3.994], p = 0.012), general anesthesia during MT (aOR[95%CI]: 2.455[1.385–4.352], p = 0.002), infectious complications (aOR[95%CI]: 1.845[1.031–3.305], p = 0.039), “other determined” etiology of stroke (aOR[95%CI]: 2.424[1.100–5.345], p = 0.028), and a MTA score exceeding age-specific cut-offs (aOR[95%CI]: 2.126[1.065–4.244], p = 0.033). Delirium was independently associated with worse functional outcome (aOR[95%CI]: 2.902[1.005–8.383], p = 0.049) at 90-day follow-up.ConclusionDelirium is independently associated with worse functional outcome after MT of LVO, stressing the importance of screening and preventive measures. Besides conventional risk factors, pathological MTA scores and use of general anesthesia during MT may be easy-to-apply criteria to identify individuals at risk of delirium and implement prevention strategies.
Relationships of hematocrit concentration with dementia from a multiethnic population-based study
Authors: Roh David J. , Liu Minghua , Strobino Kevin , Assuras Stephanie , Guzman Vanessa A. , Levin Bonnie , Spitalnik Steven L. , Rundek Tatjana , Wright Clinton B. , Elkind Mitchell S. V. , Gutierrez Jose 
Published: February 2025

ObjectiveRed blood cell (RBC) concentration impacts cerebrovascular disease, yet it is unclear whether RBC concentrations relate to dementia risk, particularly in racially/ethnically diverse cohorts. We investigated whether RBC concentrations associate with incident dementia risk in a diverse population of stroke-free individuals and explored whether cerebral small vessel disease (CSVD) mediates this relationship.MethodsA longitudinal observational analysis was performed using a population-based cohort of stroke-free, older adult participants (&gt;50 years) from the Northern Manhattan Study (NOMAS) enrolled between 2003 and 2008. Participants received baseline hematocrit testing, MRI neuroimaging, and cognitive assessments at baseline and long-term follow-up. Associations of baseline hematocrit as a categorical variable (low, normal [reference], and high based on laboratory reference levels) with incident dementia were assessed using Cox models adjusting for relevant covariates. Separate analyses investigated whether MRI CSVD mediated these relationships.ResultsWe studied 1,207 NOMAS participants (mean age 71 ± 9 years, 60% female, 66% Hispanic). Mean hematocrit was 41.2% (±3.8) with 16% of participants developing incident dementia. Lower hematocrit associated with increased dementia risk (adjusted hazard ratio 1.81 [1.01–3.23]) after adjusting for age, sex, race/ethnicity, education, APOE status, and comorbidities. High hematocrit was not associated with dementia risk. No interactions by sex or race/ethnicity were seen and baseline CSVD did not mediate relationships between hematocrit and dementia.ConclusionLow hematocrit associated with dementia risk in our diverse population cohort. However, our study limitations in laboratory and neuroimaging timing in addition to clarifying mechanistic underpinnings for our observations necessitates further work to clarify whether anemia can serve as a trackable, preventable/treatable risk factor for dementia.