bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Linker Engineering in Core‐Linked Dimeric Acceptors for High‐Performance Organic Solar Cells
Authors: Oh Shinbee , Jeong Dahyun , Bae Kihyun , Kim Geon‐U , Phan Tan Ngoc‐Lan , Lee Jin‐Woo , Park Jinseok , Lee Dongchan , Cho Shinuk , Kim Bumjoon J. 
Published: July 2024

AbstractThe dimerization of small molecule acceptors (SMAs) is a promising strategy for enhancing the long‐term stability and power conversion efficiency (PCE) of organic solar cells (OSCs). However, the reported DSMAs are primarily limited to end‐linked molecular configurations, highlighting the need for further exploration of various dimer architectures. Herein, the development of two distinct core‐linked dimerized SMAs (DYF‐V and DYF‐E) are reported with tailored linker structures (vinylene and ethynyl, respectively), achieving high‐performance OSCs (PCE = 18.53%). Interestingly, a subtle change in the linker structures results in markedly different molecular properties and photovoltaic performances of the dimer acceptors. DYF‐E with an ethynyl linker exhibits more twisted backbone conformation and mitigated aggregation property compared to DYF‐V, inducing desirable blend morphologies with a polymer donor including high crystallinity, face‐on oriented packing structures, and well‐intermixed domains. Thus, the DYF‐E‐based OSCs exhibit a high PCE (17.02%), which significantly outperforms the DYF‐V‐based OSCs (PCE = 9.98%). Furthermore, the ternary OSCs based on DYF‐E achieve a higher PCE of 18.53%. Thus, this study highlights the significance of selecting an appropriate linker in core‐linked dimerized SMAs for producing high‐performance OSCs.
Hybrid Strategy for In Situ Shaping of Zeolite‐Imidazolate‐Frameworks into Polymeric Macrocapsule: Toward Practical Applications of Rare Earth Element Recovery
Authors: Cho Eun , Jung Youngkyun , Choi Jae‐Woo , Lee Changha , Jung Kyung‐Won 
Published: July 2024

AbstractThe efficient recovery of rare earth elements (REEs) from secondary sources is an urgent global challenge. Although zeolite‐imidazolate‐framework‐8 (ZIF‐8) has unique advantages for REE recovery, its nanopowder form poses a significant obstacle to its practical application. Herein, the study proposes a novel in situ strategy for shaping ZIF‐8 into hierarchical 3D center‐radial channels of a polymeric macrocapsule (PMC) via a hybrid approach. Core–shell‐type ZIF‐8‐PMC hybrids (ZIF‐8@PMC) with the intrinsic physicochemical properties of ZIF‐8 are synthesized by combining counter‐diffusion‐based in situ growth and phase transformation, enabling unprecedented REE recovery of 463.6 and 580 mg g−1 for Nd3+ and Dy3+, respectively, which are superior to that of traditional encapsulating protocols. Moreover, ZIF‐8@PMC exhibits good applicability in the simulated permanent magnet leachate with recovery efficiencies of 92.5% (Nd3+) and 81.8% (Dy3+), after five repetitive cycles because of its protective nanoporous shell layer that prevents the release of in situ‐shaped ZIF‐8 to the exterior and invasion of external particulates into the PMC. Overall, these findings demonstrate the suitability of PMC as an ideal platform for the in situ shaping of ZIF‐8 and the application of the newly proposed protocol as a promising approach to expand the applicability of ZIF‐8 in various fields.
Three Birds with One Stone: Copper Ions Assisted Synergistic Cuproptosis/Chemodynamic/Photothermal Therapy by a Three‐Pronged Approach
Authors: Chen Mengyao , Xu Chang , Wang Chunhui , Huang Nan , Bian Zhixuan , Xiao Yixuan , Ruan Juan , Sun Fenyong , Shi Shuo 
Published: July 2024

AbstractCopper is indispensable to organisms, while its homeostatic imbalance may interference normal cellular physiological processes and even induce cell death. Artificially regulating cellular copper content provides a viable strategy to activate antineoplastic effect. In light of this, a copper ions homeostasis perturbator (CuP‐CL) with cinnamaldehyde (Cin) packaging and thermosensitive liposome coating is reported. Following laser exposure, the doping of Cu2+ in polydopamine initiates enhanced photothermal therapy (PTT) and unlocks the outer layer of liposome, leading to the release of copper ions and Cin in tumor microenvironment with mild acidity and high glutathione (GSH) levels. The liberative Cu2+ can evoke cuproptosis and chemodynamic therapy (CDT). Meanwhile, leveraging the merits of H2O2 supply and GSH consumption, Cin serves as a tumor microenvironment regulator to amplify Cu2+ mediated cuproptosis and CDT. Additionally, the positive feedback effects of “laser‐triggered PTT, PTT accelerates reactive oxygen species (ROS) generation, ROS amplifies lipid peroxide (LPO) accumulation, LPO mediates heat shock proteins (HSPs) clearance, down‐regulated HSPs promote PTT” entailed the overall benefit to therapeutic outcomes. Both in vitro and in vivo results corroborate the remarkable antineoplastic performance of CuP‐CL by the synergy of cuproptosis/CDT/PTT. Collectively, based on the three‐pronged approach, this work plots a viable multimodal regimen for cancer therapy.
Construction of Binary Matrix for Efficient Room Temperature Phosphorescence Emission
Authors: Jia Qinglong , Bo Changchang , Lu Ziyi , Xu Wensheng , Liu Jiayi , Gao Li , Chen Ligong , Wang Bowei 
Published: July 2024

AbstractDespite the extensive research on room temperature phosphorescent (RTP) materials, it remains a great challenge to further improve the photophysical properties of RTP materials. In this study, the RTP emission of guest molecule is significantly enhanced by constructing binary matrices containing cyanuric acid (CA) and amino‐containing compounds. Systematic studies show that the strong interaction between the two components of binary matrix induced variations in the guest molecular configuration and excited state electron distribution, thus facilitating the production of more triplet excitons. Furthermore, the binary matrix also exhibits stronger domain‐limiting effect compared to the CA mono‐matrix, effectively inhibits the energy loss of triplet excitons due to quenching and non‐radiative transitions. The prepared binary matrix RTP materials present ultralong phosphorescence lifetime and high phosphorescence quantum yield (up to 3.21 s and 7.31%, respectively), and even achieve bright RTP emission in a variety of organic solvents and aqueous media. Moreover, the RTP emission intensity of the best binary matrix composite can reach more than 28 times that of the CA mono‐matrix composite, and the RTP lifetime can be extended by 1.51 s.
Pd(II)‐Catalyzed Formal [5+2]‐Carbocyclization of Ortho‐Aryl‐Substituted Arylaldehydes with Allylic Alcohols
Authors: Wang Chengjie , Jiang Huanfeng , Zeng Wei 
Published: July 2024

AbstractA Pd(II)‐catalyzed formal [5+2] coupling‐cyclization of 2‐arylbenzaldehydes with allylic alcohols has been developed. The method provides an efficient approach to access diaryl‐fused cycloheptene skeletons via traceless α‐amino acid‐assisted Csp2−H activation process.
Tandem Enantioselective Cycloaromatization/Intramolecular Friedel–Crafts Desymmetrization of Cyclohexadienones
Authors: Gaviña Daniel , Durán Marta , Prieto Lidia , Escolano Marcos , Díaz‐Oltra Santiago , Sánchez‐Roselló María , del Pozo Carlos 
Published: July 2024

AbstractAn enantioselective tandem sequence that comprises a cycloaromatization process followed by an intramolecular desymmetrizing Friedel‐Crafts alkylation of functionalized cyclohexadienones has been accomplished. The process takes place in good yields (65–95%), with excellent diastereoselectivity (>20:1) and enantiomeric ratios up to 90.5:9.5 in the presence of (R)‐BINOL‐derived N‐triflyl phosphoramides, and it gains access to a family of pyrrolo[2,1‐a]isoquinoline derivatives in a simple manner, with the simultaneous generation of two vicinal stereocenters, one of them a tetrasubstituted carbon stereocenter.
Topology Optimization of Auxetic Hyperelastic Biomaterials for Enhanced Tailored Properties and Ultra‐High Expansion
Authors: Chattrairat Akanae , Kandare Everson , Aimmanee Sontipee , Tran Phuong , Das Raj 
Published: July 2024

AbstractTopology optimization using finite element analysis offers a promising approach for designing new biomaterials with mechanical properties similar to human skin and superior auxetic properties compared to conventional materials. This innovative technique addresses the challenges associated with trial‐and‐error‐based material design and experimental iterations. In this study, finite element‐based topology optimization is employed to achieve optimized material structural patterns that maximize the lateral expansion of previously established auxetic designs and replicate specific directional properties observed in human skin. The topology‐optimized models, including slit, I‐shape, anisotropic I‐shape, triangular pattern, and re‐entrant shapes, demonstrate material structures with lower maximum stress, reducing the likelihood of material rupture failure and enhancing lateral expansion by more than 50% compared to the initial patterns. These novel designs and their unique behaviors are verified using the theoretical model of hyperelastic auxetic materials. This study represents the first analysis of topology optimization applied to soft hyperelastic biomaterials, focusing on both maximizing auxetic properties and replicating auxetic properties of human skin. The auxetic designs and topology optimization technique developed in this research hold potential for integration into biomedical and personal protective applications.
SNORD3A Regulates STING Transcription to Promote Ferroptosis in Acute Kidney Injury
Authors: Zhu Huanhuan , Wang Junni , Miao Jin , Shen Mingdi , Wang Huijing , Huang Xiaohan , Ni Anqi , Wu Huijuan , Chen Jianghua , Xiao Liang , Xie Shanshan , Lin Weiqiang , Han Fei 
Published: July 2024

AbstractAcute kidney injury (AKI) signifies a sudden and prolonged decline in kidney function characterized by tubular cell death and interstitial inflammation. Small nucleolar RNAs (snoRNAs) play pivotal roles in oxidative stress and inflammation, and may play an important role in the AKI process, which remains elusive. an elevated expression of Snord3a is revealed in renal tubules in response to AKI and demonstrates that Snord3a deficiency alleviates renal injury in AKI mouse models. Notably, the deficiency of Snord3a exhibits a mitigating effect on the stimulator of interferon genes (STING)‐associated ferroptosis phenotypes and the progression of tubular injury. Mechanistically, Snord3a is shown to regulate the STING signaling axis via promoting STING gene transcription; administration of Snord3a antisense oligonucleotides establishes a significant therapeutic advantage in AKI mouse models. Together, the findings elucidate the transcription regulation mechanism of STING and the crucial roles of the Snord3a‐STING axis in ferroptosis during AKI, underscoring Snord3a as a potential prognostic and therapeutic target for AKI.
Biomimetic Metal–Organic Framework Gated Nanoplatform for Sonodynamic Therapy against Extensively Drug Resistant Bacterial Lung Infection
Authors: Huang Jianling , Hong Xiuwen , Chen Sixi , He Yucong , Xie Lixu , Gao Fenglin , Zhu Chenghua , Jin Xiao , Yan Haihao , Ye Yongxia , Shao Mingyue , Du Xingran , Feng Ganzhu 
Published: July 2024

AbstractNovel antimicrobial strategies are urgently needed to treat extensively drug‐resistant (XDR) bacterial infections due to the high mortality rate and lack of effective therapeutic agents. Herein, nanoengineered human umbilical cord mesenchymal stem cells (hUC‐MSCs), named PMZMU, are designed as a sonosensitizer for synergistic sonodynamic‐nano‐antimicrobial therapy against gram‐negative XDR bacteria. PMZMU is composed of a bacterial targeting peptide (UBI29‐41) modified hUC‐MSCs membrane (MSCm), a sonosensitizer meso‐tetra(4‐car‐boxyphenyl) porphine doped mesoporous organo‐silica nanoparticle and an acidity‐responsive metal–organic framework ZIF‐8. This innovative formulation enables efficient loading of polymyxin B, reduces off‐target drug release, increases circulation and targeting efficacy, and generates reactive oxygen species upon ultrasound irradiation. PMZMU exhibits remarkable in vitro inhibitory activity against four XDR bacteria: Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa (PA), and Escherichia coli. Taking advantage of the bacterial targeting ability of UBI29‐41 and the inflammatory chemotaxis of hUC‐MSC, PMZMU can be precisely delivered to lung infection sites thereby augmenting polymyxin B concentration. PMZMU‐mediated sonodynamic therapy significantly reduces bacterial burden, relieves inflammatory damage by promoting the polarization of macrophages toward M2 phenotype, and improves survival rates without introducing adverse events. Overall, this study offers promising strategies for treating deep‐tissue XDR bacterial infections, and guides the design and optimization of biomimetic nanomedicine.
piRNA PROPER Suppresses DUSP1 Translation by Targeting N6‐Methyladenosine‐Mediated RNA Circularization to Promote Oncogenesis of Prostate Cancer
Authors: Ben Shuai , Ding Zhutao , Xin Junyi , Li Feng , Cheng Yifei , Chen Silu , Fan Lulu , Zhang Qin , Li Shuwei , Du Mulong , Zhang Zhengdong , Wei Gong‐Hong , Cheng Gong , Wang Meilin 
Published: July 2024

AbstractGenetic and epigenetic alterations occur in many physiological and pathological processes. The existing knowledge regarding the association of PIWI‐interacting RNAs (piRNAs) and their genetic variants on risk and progression of prostate cancer (PCa) is limited. In this study, three genome‐wide association study datasets are combined, including 85,707 PCa cases and 166,247 controls, to uncover genetic variants in piRNAs. Functional investigations involved manipulating piRNA expression in cellular and mouse models to study its oncogenetic role in PCa. A specific genetic variant, rs17201241 is identified, associated with increased expression of PROPER (piRNA overexpressed in prostate cancer) in tumors and are located within the gene, conferring an increased risk and malignant progression of PCa. Mechanistically, PROPER coupled with YTHDF2 to recognize N6‐methyladenosine (m6A) and facilitated RNA‐binding protein interactions between EIF2S3 at 5′‐untranslated region (UTR) and YTHDF2/YBX3 at 3′‐UTR to promote DUSP1 circularization. This m6A‐dependent mRNA‐looping pattern enhanced DUSP1 degradation and inhibited DUSP1 translation, ultimately reducing DUSP1 expression and promoting PCa metastasis via the p38 mitogen‐activated protein kinase (MAPK) signaling pathway. Inhibition of PROPER expression using antagoPROPER effectively suppressed xenograft growth, suggesting its potential as a therapeutic target. Thus, targeting piRNA PROPER‐mediated genetic and epigenetic fine control is a promising strategy for the concurrent prevention and treatment of PCa.
A Lipid‐Sensitive Spider Peptide Toxin Exhibits Selective Anti‐Leukemia Efficacy through Multimodal Mechanisms
Authors: Zhang Peng , Luo Wu , Zhang Zixin , Lv Mingchong , Sang Longkang , Wen Yuhan , Wang Lingxiang , Ding Changhao , Wu Kun , Li Fengjiao , Nie Yueqi , Zhu Jiaoyue , Liu Xiaofeng , Yi Yan , Ding Xiaofeng , Zeng Youlin , Liu Zhonghua 
Published: July 2024

AbstractAnti‐cancer peptides (ACPs) represent a promising potential for cancer treatment, although their mechanisms need to be further elucidated to improve their application in cancer therapy. Lycosin‐I, a linear amphipathic peptide isolated from the venom of Lycosa singorensis, shows significant anticancer potential. Herein, it is found that Lycosin‐I, which can self‐assemble into a nanosphere structure, has a multimodal mechanism of action involving lipid binding for the selective and effective treatment of leukemia. Mechanistically, Lycosin‐I selectively binds to the K562 cell membrane, likely due to its preferential interaction with negatively charged phosphatidylserine, and rapidly triggers membrane lysis, particularly at high concentrations. In addition, Lycosin‐I induces apoptosis, cell cycle arrest in the G1 phase and ferroptosis in K562 cells by suppressing the PI3K‐AKT‐mTOR signaling pathway and activating cell autophagy at low concentrations. Furthermore, intraperitoneal injection of Lycosin‐I inhibits tumor growth of K562 cells in a nude mouse xenograft model without causing side effects. Collectively, the multimodal effect of Lycosin‐I can provide new insights into the mechanism of ACPs, and Lycosin‐I, which is characterized by high potency and specificity, can be a promising lead for the development of anti‐leukemia drugs.
Switching Dynamics and Improved Efficiency of Free‐Standing Antiferroelectric Capacitors
Authors: Saeed Umair , Pesquera David , Liu Ying , Fina Ignasi , Ganguly Saptam , Santiso José , Padilla‐Pantoja Jessica , Caicedo Roque José Manuel , Liao Xiaozhou , Catalan Gustau 
Published: July 2024

AbstractThe switching dynamics of antiferroelectric lead zirconate (PbZrO3) freestanding capacitors compared to their epitaxial counterparts is reported. Frequency dependence of hysteresis indicates that freestanding capacitors exhibit a lower dispersion of switching fields, lower residual polarization, and faster switching response as compared to epitaxially‐clamped capacitors. As a consequence, freestanding capacitor membranes exhibit better energy storage density and efficiency.
Universal free school meals: Examining factors influencing adoption of the Community Eligibility Provision
Authors: Kashyap Pratyoosh , Jablonski Becca B. R. 
Published: July 2024

AbstractRecognizing school meals as critical safety nets for children in low‐income households, many states are passing legislation to adopt universal free school meals, linking their funding to the Community Eligibility Provision (CEP), a federally funded universal free school meal program. However, about half of all eligible school districts did not participate in CEP in the school year 2018–2019. Using a policy diffusion approach and a Cox regression model, this research demonstrates the importance of a school district's identified student percentage (poverty level) and a state's direct certification rate (certifying students for free meals) in increasing the likelihood of CEP adoption.
Recent Advances in Synthesis of Enantioenriched 2‐Substituted Piperidine Derivatives
Authors: R Balaji , David A. John , Das Anjan 
Published: July 2024

AbstractEnantioenriched 2‐substituted piperidines are very important unit for drug discovery. Ready access to a wide range of such compounds, decorated with functional handles at 2‐position with stereo‐defined centre significantly enhance the quality and diversity of chemical libraries for screening of drug discovery. The ability to control the stereochemistry of piperidine at the 2‐position remains an area of interest in organic synthesis to allow the development of novel, structurally diverse 3D molecules. Among the various ways to obtain enantioenriched 2‐substituted piperidines, asymmetric hydrogenation is widely studied. Asymmetric synthesis, Kinetic resolution, and chiral pool synthesis methodologies are also important ways to obtain the enantioenriched 2‐substituted piperidines. This review article summarized the main four ways to achieve particularly the enantioenriched substituted piperidines only at 2‐position considering the chemical routes, excluding the biocatalytic approach. 1. Introduction 2.1 Asymmetric Hydrogenation of 2‐substituted Pyridines 2.2 Asymmetric Synthesis 2.3. Kinetic resolution of racemic 2‐substituted Piperidine derivatives 2.4. Chiral pool synthesis 3. Conclusions & outlook
Lewis Acid‐Catalyzed Tandem Annulation of Propargylic Alcohols with 2‐Allylphenols and Their Anti‐tumor Activities
Authors: Li Xiang , Guo Ning‐Yu , Liu Qing‐Hui , Han Ya‐Ping , Zhang Hong‐Yu , Peng Li‐Zeng 
Published: July 2024

AbstractA novel bismuth(III) trifluoro‐methanesulfonate‐catalyzed and environmentally benign synthetic strategy for the construction of a wide range of structurally diverse, sophisticated [5,6,5]‐oxygen‐containing tricyclic frameworks with easy‐to handle propargylic alcohols and 2‐allylphenols as substrates in the presence of Bi(OTf)3 and AgOTf is described. This Lewis acid catalyzed [3+2] annulation protocol, which tolerates a great deal of functional groups, proceeds through a sequential Meyer‐Schuster rearrangement, nucleophilic substitution, 5‐exo‐trig cyclization, 5‐endo‐trig cyclization, and proton exchange sequences, affording a versatile approach for accessing oxygen‐containing tricyclic skeletons in moderate‐to‐excellent yields. In addition, most of the obtained compounds exhibited anti‐tumor activities against three types of human cancer cell lines in vitro, including Caco‐2 colon cancer cells, MCF‐7 breast cancer cells, and Hepg‐2 liver cancer cells.
Individual differences in sociocognitive traits in semi‐free‐ranging rhesus monkeys (Macaca mulatta)
Authors: Diaz Alexis A. , Hernández‐Pacheco Raisa , Rosati Alexandra G. 
Published: July 2024

AbstractCharacterizing individual differences in cognition is crucial for understanding the evolution of cognition as well as to test the biological consequences of different cognitive traits. Here, we harnessed the strengths of a uniquely large, naturally‐living primate population at the Cayo Santiago Biological Field Station to characterized individual differences in rhesus monkey performance across two social cognitive tasks. A total of n = 204 semi‐free‐ranging adult rhesus monkeys participated in a data collection procedure, where we aimed to test individuals on both tasks at two time‐points that were one year apart. In the socioemotional responses task, we assessed monkeys' attention to conspecific photographs with neutral versus negative emotional expressions. We found that monkeys showed overall declines in interest in conspecific photographs with age, but relative increases in attention to threat stimuli specifically, and further that these responses exhibited long‐term stability across repeated testing. In the gaze following task we assessed monkeys' propensity to co‐orient with an experimenter. Here, we found no evidence for age‐related change in responses, and responses showed only limited repeatability over time. Finally, we found some evidence for common individual variation for performance across the tasks: monkeys that showed greater interest in conspecific photographs were more likely to follow a human's gaze. These results show how studies of comparative cognitive development and aging can provide insights into the evolution of cognition, and identify core primate social cognitive traits that may be related across and within individuals.