bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Delayed Graft Function and Cytomegalovirus Infection after Renal Transplant
Authors: Liu Luhao , Chen Rongxin , Cai Jiali , Wubuli Maierheba , Zheng Boyu , Wang Junhan , Li Xiangyou , Lin Yujing , Chen Zheng , Li Guanghui 
Published: February 2025

Abstract

Background: Delayed graft function (DGF) increases the renal allograft failure risk. The objective of this study was to estimate the incidence of CMV infection and to analyze whether DGF is associated with an increased risk of CMV infection.
Methods: This single center, retrospective, cohort study of deceased donor renal transplant recipients assessed CMV outcomes in patients experiencing DGF versus those without DGF. Univariate and multivariate hazard ratios were calculated with a Cox model.
Results: Data from 124 recipients were evaluated (Mean age 44.72±9.97 years, 89 males). Cytomegaloviruria during 1 year after transplantation was diagnosed in 16 patients (12.9%). Patients with DGF were at a greater risk of cytomegaloviruria than patients without DGF (P=0.026). Furthermore, the lymphocyte proportion and CD4+ T cells absolute counts of the DGF group were lower than the without DGF group (p= 0.031 and p=0.012).
Conclusion: Our data support the hypothesis that renal transplant recipients with DGF are at increased risk of developing cytomegaloviruria. Prospective studies evaluating to monitor CMV viral loads and CD4+ T lymphocyte numbers in patients with DGF are needed.
Trial registration：
Clinical Research and Application Ethics Committee of the Second Affiliated Hospital of Guangzhou Medical University:2024-hg-ks-46.Registered 22 October 2024.
Screening and identification of Lactic acid bacteria with α-glucosidase inhibiting activity
Authors: Liu Yi , Yang Zixuan , Liu Ang , Dong Baiyu , Yao Qiuping , Ran Xinglin , Zhu Dequan 
Published: February 2025

Abstract

In this study, Lactic acid bacteria were isolated from traditional fermented foods in Guizhou. The fermentation supernatant and cell disruption extract were used to screen Lactic acid bacteria with α-glucosidase inhibitory activity, and the active Lactic acid bacteria strains with potential hypoglycemic effect were screened. The results showed that 10 strains were screened from 27 strains of Lactic acid bacteria with α-glucosidase inhibitory activity, of which 5 strains had good acid and bile salt tolerance. The best acid resistance was XG01, and the survival rate was as high as 98.5%. ST01 had the strongest tolerance to bile salt, up to 77.3%. Through molecular biological identification, HLG01, YR01, and ST01 were Lactiplantibacillus plantarum, XG01 was Pediococcus pentosaceus, and JR01 was Weissella cibaria. Five strains of Lactic acid bacteria with good tolerance were screened out, which provided a strain basis for the subsequent study of the hypoglycemic effect of Lactic acid bacteria and the development of various functional foods.
OCT Macular Changes in Type 1 ROP following Ranibizumab Injections
Authors: Hosny Rawan , Gouda Jylan , Macky Tamer A , Khattab Ayman , Mekkawy Hany , Abdullatif Abdussalam Mohsen 
Published: February 2025

Abstract

Aim
To investigate the OCT macular changes in type 1 ROP one month following Ranibizumab injections.
Methods
Preterm infants with type 1 ROP indicated for ranibizumab injections were included in this study. Handheld OCT imaging was performed at baseline, 1 week, and 1 month post injection. Central full thickness (CFT), inner retinal layer (IRL), and outer retinal layer (ORL) thickness measurements were taken from foveal center and parafoveal region.
Results
24 eyes of 12 infants were included in this study. There were no significant changes in the mean CFT and IRL thickness at 1 month (p = 0.5 and 0.1 respectively). However, there was significant increase in the mean ORL thickness at 1 month (69.9 ± 16, 96.1 ± 25 at baseline and one month respectively, p < 0.001), with differentiation (appearance of IS/OS junction ± ELM) in 55.6% of eyes. Macular edema (ME) was observed in 12 eyes (50%) and was associated with smaller birth weight (p = 0.0290). There was no significant decrease in mean CFT in eyes with ME at 1 month (p = 0.13), with complete resolution in only 6 eyes (50%) during the study period. Regression of plus was associated with lower CFT (1 week and 1 month; p = 0.02 and 0.03, respectively).
Conclusion
Intravitreal ranibizumab in eyes with type 1 ROP is associated ORL thickening and earlier differentiation as well as IRL thinning but with inadequate resolution of ME.
Origins of rapid solvated-calcium ion co-intercalation in graphite anodes
Authors: Xu Zheng-Long , Yi Yuyang , Chang Yide , Li Renjie , Lyv Linlong , Zhang Zeyu , Meng Qi , Lin Huijun , Jiang Pengyan , Lu Di , Wang Yanming , Fan Xiulin 
Published: February 2025

Abstract

Co-intercalation reaction unlocks reversible calcium (Ca) ion storage in graphite anodes, a breakthrough unattainable with conventional intercalation chemistry. However, the underlying mechanisms driving the rapid co-intercalation reaction remain unclear. Here we reveal that reversible Ca storage in graphite only occurs in electrolytes that simultaneously meet three critical criteria: high Ca2+ solvation strength in bulky electrolyte, the low intercalation energy at electrolyte/graphite interface, and fast [Ca-solvent]2+ diffusion kinetics within graphite galleries. Among various solvents, only those based on amides enable Ca2+ intercalation in graphite, attributable to their high dielectric constants (ε > 20) and strong binding energies (Eb > 5 eV) with Ca2+. Upon intercalation, both thermodynamic (the intercalation energy: Eint < 0) and kinetic (diffusion energy barriers: Ediff = 0.19 eV) factors are equally critical in regulating the Ca ion storage behaviors. Positive intercalation energies and slow [Ca-solvent]2+ migration kinetic result in reduced storage capacities and lattice rearrangements in graphite intercalation compounds. In the optimized dimethylacetamide-based electrolyte, graphite anodes achieve 80% capacity retention over 750 cycles and high-rate capability at 0.2 A g− 1 in Ca-ion cells. The intriguing co-intercalation chemistry expands the promise for graphite anodes in non-lithium ion battery systems.
Avapritinib monotherapy induces rapid and deep remission of heavily treated, KIT D816H-mutated t(8;21) acute myeloid leukemia
Authors: Getz Ted M. , Bakirhan Kamila , Seropian Stuart , Shallis Rory M. 
Published: February 2025

Abstract

Acute myeloid leukemia (AML) with t(8;21) is a subset of core binding factor AML and is considered to be favorable risk disease in patients receiving intensive cytarabine based chemotherapy. However, relapse remains a significant clinical challenge. Mutations in KIT, which frequently co-occur in t(8;21) AML, have been associated with worse relapse free and overall survival. Avapritinib is a novel tyrosine kinase inhibitor targeting KIT mutations that is currently approved for systemic mastocytosis but doesn’t currently have an established role in the treatment of AML. Here we report the case of a patient with heavily treated KIT D816H-mutated t(8;21) AML that relapsed following allogeneic hematopoietic stem cell transplant who received avapritinib monotherapy with rapid induction of a deep remission. This case highlights the potential role of avapritinib as a targeted therapy for relapsed t(8;21) AML with KIT mutations, warranting further clinical investigation.
Young-onset diabetes poses a greater risk of end-stage renal disease (ESRD) than cardiovascular disease and stroke: a retrospective cohort study of UK Biobank
Authors: Kar Debasish , Byng Richard , Spicer Stuart , Farina Nicolas , Pinkney Jonathan , Song Soon , Zabeen Bedowra , Kar Shubharthi , Jonnagaddala Jitendra , Liaw Siaw-Teng , El-Wazir Aya , Nath Mintu , Khan Moein AB , Sheikh Aziz , de Lusignan Simon 
Published: February 2025

Abstract

Background
In the last three decades, in people with diabetes, while the mortality and morbidity due to cardiovascular disease (CVD) and stroke have declined, the incidence of end-stage renal disease (ESRD) has crept up. The precise cause for this shift is unknown. Intriguingly, during the same period, the incidence of diabetes in younger people has almost tripled worldwide. This study examines whether young-onset diabetes is a greater risk for ESRD compared to CVD and stroke.
Methods
We conducted this retrospective cohort study using data from volunteers (n = 502,408) aged 40–69 years recruited in UK Biobank between 2006 and 2010. The exposure variable was the age of diabetes diagnosis, while the outcomes of interest were ESRD, myocardial infarction, angina, and stroke. The cumulative follow-up period from the mean age of diabetes to the mean age of the outcomes of interest was 838,592 person-years. Univariate and multivariate logistic regression models were fitted to assess odds ratios (ORs) and 95% confidence intervals (CIs). Model performance was evaluated using receiver operating characteristics (ROC) analysis and calibration plots.
Findings:
Out of 26,206 people with diabetes, 1.16% (n = 303) had ESRD, 8.58% (n = 2250) had a myocardial infarction, 7.47% (n = 1958) had angina, and 2.94% (n = 771) had a stroke. Compared to later-onset, young-onset diabetes is linked with an earlier onset of ESRD. Based on the age of diabetes diagnosis, the univariate logistic regression showed that compared to those diagnosed after the age of 60, the odds of ESRD for those diagnosed at ages < 20, 20–40, and 41–60 years were OR [2.33 (95% CI 1.50–3.84), 7.78 (95% CI 4.81–13.16), and 5.26 (95% CI 3.00–9.40)], respectively. Myocardial infarction and stroke did not have a statistically significant relationship with diabetes diagnosis age. Multivariate models adjusted for sex and albuminuria confirmed the increased odds of ESRD in people with younger onset and longer duration of diabetes.
Interpretation:
People with younger onset and longer duration of diabetes are at a higher risk of ESRD than CVD and stroke.
Study on the Mixing Properties of Bamboo Fiber and Loose Soil
Authors: Ding Honggang , Zhang Yanjie , Zuo Ao , Zhou Liping 
Published: February 2025

Abstract

The stability of the slope is of great significance to the safety of life and property. In order to solve the problem of single -slope pine loose reinforcement methods, and the limitation in chemistry and biological methods, and bamboo fiber is used to strengthen the loose soil. Through direct shearing tests and scanning electron microscopes, the mechanical characteristics and interaction mechanism of bamboo fiber and loose soil reinforcement are studied. The research results show that the fiber and loose soil is mainly connected through micro-particles. The closer to the fiber, the more the number of micro -grains; with the increasing of fiber content, the increase in the shear strength of the mixture is increased sharply after the shear strength increases first, and then slightly decreased; appropriate amount of micro -mucous particles can significantly enhance the shear strength of the mixture, and excessive micro -mucous particles can cause the intensity of the mixture to decrease. The results of the research can provide theoretical reference for engineering projects such as road slope, building slope, tail mining, and artificial pile of earth soil.
Could the total renal chronicity score at renal biopsy and baseline creatinine be predictive of long-term renal survival in primary membranous nephropathy patients?
Authors: Kocaayan Hasan , Uzum Yusuf , Ertekin Ibrahim , Cakalagaoglu Fulya , Soypacaci Zeki 
Published: February 2025

Abstract

Objective: Renal survival is important in patients with idiopathic membranous nephropathy (IMN). In this study we investigated the factors affecting renal survival in IMN patients
Methods: This retrospective single center cohort study included patients who were diagnosed with IMN by renal biopsy between January 2009 and February 2019 and had a 5-year follow-up. Age, gender, serum creatinine, serum albumin, 24-hour proteinuria of the patients at the time of renal biopsy were recorded. The total renal chronicity score was calculated from the results of renal biopsy and patients were divided into minimal and non-minimal (including mild, moderate and severe) according to the total chronicity score. Renal survival was defined as at least a two-fold increase in serum creatinine from baseline and the need for renal replacement treatment (RRT).
Results: Twenty patients (40%) had doubled serum creatinine levels or needed RRT. In univariate analysis, age, serum creatinine, serum albumin, serum albumin grade (<3g/dl) and total renal chronicity grade were found to be risk factors for renal survival. Multivariate Cox regression analysis revealed that the serum creatinine level [hazard ratio (HR) 2.38, confidence interval (CI) 1.37-4.11, p=0.02], serum albumin level (HR 0.43, CI 0.23-0.8, p=0.008) and total renal chronicity score grade (HR 14.4, CI 3.2-64.6, p:<0.001) were independent risk factors for renal survival.
Conclusions: Low albumin levels (especially <3g/dl), high serum creatinine levels and high total renal chronicity scores (the presence of non-minimal degree of chronic change) on renal biopsy at the time of diagnosis are predictive of poor renal survival.
Neonatal cell population data: reference intervals and relevance for detecting sepsis and necrotizing enterocolitis
Authors: Ferraro Flavia , Fillistorf Laura , Dimopoulou Varvara , Alberio Lorenzo , Coutaz Christine , Meylan Sylvain , Matusiak Raphael , Despraz Jeremie , Giannoni Eric 
Published: February 2025

Abstract

Timely diagnosis of neonatal sepsis is crucial but remains challenging with existing tools. Cell Population Data (CPD) provide high-resolution phenotypic analysis of leukocytes, offering potential for sepsis detection. We aimed to establish neonatal CPD reference intervals and explore their potential for early recognition of sepsis and necrotizing enterocolitis (NEC). Neutrophil, monocyte, and lymphocyte CPD from hospitalized newborns were analyzed. Reference intervals (5th to 95th percentiles), at birth and during the first 28 days, were derived from newborns without conditions potentially impacting CPD (controls). CPD obtained on the day of clinical suspicion from newborns with blood culture-proven sepsis and/or NEC were compared to controls, and their performance in detecting sepsis/NEC was compared with complete blood count (CBC) and C-reactive protein (CRP). Reference intervals from 905 controls showed that mean CPD values had distinct trajectories for each parameter, while distribution width generally decreased with increasing gestational and postnatal age. CPD in 39 sepsis/NEC cases differed from controls, particularly neutrophil fluorescence intensity (NE-SFL) (56.2 vs. 41.1 arbitrary units, P < 0.001). NE-SFL had superior accuracy over other CPD, CBC, and CRP, with 90% sensitivity and 76% specificity. This study establishes neonatal CPD reference intervals and identifies NE-SFL as a potential sepsis biomarker.
Transcultural adaptation and psychometric properties of the Spanish version of Participation and Environment Measurement - Children and Youth (PEM-CY)
Authors: Gómez-Vela María , Baz Mª Begoña Orgaz , Vicario-Molina Isabel , Ortega Eva González , Corbella Marta Badia 
Published: February 2025

Abstract

Background
The Participation and Environment Measure for Children and Youth (PEM-CY) captures a child’s participation across home, school, and community-based activities as well as environmental factors perceived as supporting/hindering this participation. This tool has been translated into Spanish for use in the United States and Colombia but there are linguistic and sociocultural differences between these countries and Spain. Therefore, it is necessary to develop a country-specific measure to promote environment-based interventions for Spanish children with disabilities. This study aims to adapt the PEM-CY for use with children and youth in Spain, and to investigate its psychometric properties.
Methods
713 parents of children with (n = 233) and without (n = 480) disabilities, aged 5 to 17, completed the Spanish version of PEM-CY. For the test–retest reliability study, 30 of these parents completed the instrument twice.
Results
Internal consistency (0.58–0.97) and test–retest reliability (0.31–0.92) ranged from moderate to very satisfactory, according to Cronbach’s alpha and intraclass correlation coefficients. Discriminant validity, assessed through two-way ANOVA, was supported by significant differences between children with and without disabilities on participation and environment scales (p < .05). Some significant age differences were identified for participation at home and school. Validity was supported by a significant negative Pearson’s correlation (-0.32 to -0.41, p < .05) between desire for change and overall environmental supports.
Conclusions
The Spanish version of the PEM-CY is a valid and reliable tool to determine the participation and associated environmental factors in Spanish children and youth, with and without disabilities. It provides useful information for designing environment-based interventions to promote their participation.
Impact of Food Advertising Restrictions in Portugal on Children’s Exposure to Unhealthy Foods and Beverages: A Before-and-After Study
Authors: Royo-Bordonada Miguel Ángel , Cavero-Esponera Cristina , Romero-Fernández María Mar 
Published: February 2025

Abstract

Background
Portugal has one of the highest prevalences of childhood obesity in the world. Food advertising, which largely affects the most vulnerable children, contributes to childhood obesity by fostering the consumption of ultra-processed foods and beverages. To prevent this pernicious influence, Portugal passed Act 30/2019 which introduces food advertising restrictions targeted at children and adolescents under 16 years of age. The aim of this study was to assess the Act’s effectiveness in reducing the exposure of children and adolescents under14 years of age to television advertising of unhealthy foods and beverages.
Methods
We conducted a before-and-after study by measuring the impact of food sector television advertising over the course of two, week-long periods, the first in February 2019 and the second in February 2022. The respective samples included 1121 and 983 children and adolescents aged 4 to 14 years, representative of the Portuguese population in this age range. The nutritional quality of the products advertised was analysed using the nutritional profile issued by the Directorate-General of Health. Before-and-after mean impacts and coverages were compared, using the Chi-squared test to analyse differences in the latter.
Results
The weekly mean impacts of unhealthy food and beverage advertisements remained stable from 2019 to 2022 (18.9 vs. 18.7). Even so, impacts decreased in the case of low-class children and increased in the case of middle and high-class children. While overall coverage did not vary, it decreased in the morning and afternoon time slots, and increased across the night time slot. As compared to 2019, the weekly number of unhealthy food and beverage commercials increased by 25% in 2022.
Conclusions
Act 30/2019 did not reduce Portuguese children’s overall exposure to advertisements for unhealthy foods and beverages. In order to be effective, restrictions would, at minimum, have to cover television advertising during the 7 am-12 pm time band, regardless of the intended recipients of the messages, target public or percentage of children’s audience.
Boron’s Role in B16-F10 Melanoma: Cytotoxic, Antioxidant, Apoptotic, and Anti-inflammatory Effects
Authors: varol mehmet , Subasi Bugra , Koldemir-Gündüz Meliha , Yerlikaya Azmi 
Published: February 2025

Abstract

Aim Malignant melanoma is a fatal cancer type with a high risk of metastasis. Despite traditional treatments, the survival time of patients is usually 3–9 months. Therefore, new treatment strategies are needed. The aim of this study was to examine the potential role of boric acid in the treatment of melanoma through the evaluation of the cytotoxic, oxidative stress, anti-inflammatory, apoptotic effects of boric acid on B16-F10 mouse melanoma cell line.Method The cytotoxic effect was determined using the MTT method. TNF-α, IL-6, Bax, Bcl-2, and p53 gene expressions were determined with qPCR. MDA, GSH levels, and CAT activity were measured with a spectrophotometric method. The ELISA method was used for the evaluation of TNF-α, IL-1β, IL-6, IL-10, annexin-V, and Bcl-2 levels. Giemsa staining was used in the histological examinations.Results The results demonstrated that boron treatment induced dose-dependent apoptosis by reducing cell viability, compared to the untreated control cells. In the cells treated with boron, while Bcl-2 gene expression was decreased, the expression of Bax, p53 gene expressions and the level of annexin-V was increased. It was also seen that TNF-α and IL-6 mRNA expression levels and IL-1β and IL-10 levels were decreased in the cells treated with boron. Following boron treatment, an increase in CAT activity, as well as higher levels of GSH and MDA, was observed.Conclusion Boron could be effective in the treatment of melanoma through creating oxidative stress, decreasing TNF-α and IL-6 levels. This compound can be evaluated as a promising cancer treatment agent.Level of Evidence: 5
ڕۆڵی پڕۆژه‌ی ڕاهێنانی وه‌زاره‌تی په‌روه‌رده‌‌ له‌ ده‌ستخستنی كارامه‌ییه‌ بنچینه‌ییه‌كانی وانه‌وتنه‌وه‌ لای مامۆستایانی قۆناغی بنه‌ڕه‌تی
Authors: Aram Issa Mirza  , Rahbar Masood Abdulkhaleq  , Azeez Saeed Azeez  
Published: February 2025

پوخت
ئه‌م توێژینه‌وه‌یه‌ ئه‌نجامدراوه‌ به ‌مه‌به‌ستی زانینی ڕۆڵی پڕۆژه‌ی ڕاهێنانی وه‌زاره‌تی په‌روه‌رده‌ له‌ ده‌ستخستنی كارامه‌ییه‌ بنچینه‌ییه‌كانی وانه‌وتنه‌وه‌ لای مامۆستایانی قۆناغی بنه‌ڕه‌تی، و ده‌رخستنی جیاوازییه‌كان به‌پێی گۆڕاوه‌كانی (ڕه‌گه‌ز، ساڵانی خزمه‌ت و پسپۆری). توێژه‌ران ڕێبازی وه‌سفی شیكارییان به‌كارهێناوه‌. كۆمه‌ڵگه‌ی توێژینه‌وه‌كه‌ بریتیبوو له‌ سه‌رجه‌م مامۆستایانی بازنه‌ی دووه‌م له‌ په‌روه‌رده‌ی ناوه‌ندی هه‌ولێر بۆ ساڵی خوێندنی (2023-2024). توێژه‌ران بۆ به‌ده‌ستهێنانی ئامانجه‌كه‌یان، پێوه‌ری ڕاهێنانی كارامه‌ییه‌ بنچینه‌ییه‌كانی وانه‌وتنه‌وه‌یان بنیاتنا به‌پێی بنه‌ماكانی پیوانه‌ و هه‌ڵسه‌نگاندنی په‌روه‌رده‌یی‌، دوای دڵنیابوونه‌وه‌ له‌ جێگیری پێوه‌ره‌كه‌، پیوه‌ره‌كه‌ جێبه‌جێكرا له‌سه‌ر نموونه‌ی سه‌ره‌كی توێژینه‌وه‌كه‌، كه‌ پێكهاتبوو له‌ (150) مامۆستا له‌ هه‌ردوو ڕه‌گه‌ز. دوای كۆكردنه‌وه‌ی داتاكان، ڕێكخستن و شیكردنه‌وه‌یان به‌ هه‌گبه‌ی ئاماری (SPSS) توێژه‌ران گه‌یشتنه‌ ئه‌م ئه‌نجامانه‌:
1– پرۆژه‌ی ڕاهێنانی وه‌زاره‌تی په‌روه‌رده‌ ڕۆڵێكی ئه‌رێنی هه‌بووه‌ له‌ ده‌ستخستنی كارامه‌ییه‌ بنچینه‌ییه‌كانی وانه‌وتنه‌وه‌ لای مامۆستایان به‌ ڕێژه‌ی سه‌دی (78%) و ئاستی (ناوه‌ند).
2- جیاوازی به‌ڵگه‌داری ئاماری هه‌بوو له‌ ئاستی (0.05) له‌ نێوان ڕه‌گه‌زی (نێر و مێ)، له‌ به‌رژه‌وه‌ندی ڕه‌گه‌زی نێر.
3- جیاوازی به‌ڵگه‌داری ئاماری هه‌بووه‌‌ له‌ ئاستی (0.05) له‌ نێوان چینه‌كانی ساڵانی خزمه‌ت، جیاوازییه‌كه‌ش به‌زۆری له‌ نێوان چینه‌كانی (كه‌متر له‌ 15، و زیاتر له‌ 22) ده‌ركه‌وتبوو.
4- جیاوازی به‌ڵگه‌داری ئاماری نه‌بوو‌ له‌ ئاستی (0.05) له‌ نێوان پسپۆری (كۆمه‌ڵایه‌تی، زانست).