bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational Capacity for Sexual Assault Prevention Within a U.S. Army Installation
Authors: Hazlett Abigail D , Benzer Justin K , Montejos Kendra , Pittman Demietrice L , Creech Suzannah K , Claborn Kasey R , Acosta Joie , Chinman Matthew 
Published: June 2024

ABSTRACT

Introduction
Preventing military sexual assault (SA) is a DoD priority. Building prevention capacity could strengthen the impact of prevention programs and improve outcomes. Capacity was conceptualized as implementation knowledge and skills using the Getting To Outcomes (GTO) process and organizational-level capacities using the Prevention Evaluation Framework, a framework that applies best practices in prevention and implementation science to prevention at the program and organizational level. The present study assesses implementation knowledge and skills currently possessed by SA prevention personnel in one U.S. Army installation with the goal of identifying preexisting proficiencies and potential gaps. The study uses the Prevention Evaluation Framework organizational-level domains to identify organizational capacities that could be improved.

Materials and Methods
Fifteen SA prevention program personnel were recruited for individual 1-hour interviews from one U.S. Army installation. A semi-structured interview guide was developed by the study team to assess knowledge and skills within the GTO framework. Applied thematic analysis guided data coding and analysis.

Results
Participants reported a range of proficiencies and gaps in capacity for SA prevention. Within the prevention workforce capacity, proficiencies were skill in tailoring training, and an existing train-the-trainer model. Gaps were training to facilitate difficult conversations, and an inability to tailor trainings to audience needs. Two proficiencies related to the comprehensive approach were having a victim advocate present during trainings, and providing training across leadership levels. The final proficiency involved data. Existing data sources were viewed as useful for identifying the nature and extent of local problems. However, participants reported a lack of confidence and skill in selecting appropriate outcome measures and collecting and using primary data. Gaps in leadership capacity were cultural norms, lack of trust, leader investment, logistical difficulty working with leaders, and comfort engaging with leaders. Gaps in collaborative relationships were the lack of informal networking within the SA prevention area to include civilians.

Conclusions
The GTO-specific knowledge and skills of SA prevention personnel at one U.S. Army installation revealed proficiencies and gaps in organizational capacities influencing the prevention mission. Findings indicate that GTO support could be useful for improving the quality of program activities. However, results also indicate that GTO support would be more effective if they were paired with sufficient prevention infrastructure at the organizational level.
Magnetorotational dynamo can generate large-scale vertical magnetic fields in 3D GRMHD simulations of accreting black holes
Authors: Jacquemin-Ide Jonatan , Rincon François , Tchekhovskoy Alexander , Liska Matthew 
Published: June 2024

ABSTRACT
Jetted astrophysical phenomena with black hole engines, including binary mergers, jetted tidal disruption events, and X-ray binaries, require a large-scale vertical magnetic field for efficient jet formation. However, a dynamo mechanism that could generate these crucial large-scale magnetic fields has not been identified and characterized. We have employed three-dimensional global general relativistic magnetohydrodynamical simulations of accretion discs to quantify, for the first time, a dynamo mechanism that generates large-scale magnetic fields. This dynamo mechanism primarily arises from the non-linear evolution of the magnetorotational instability (MRI). In this mechanism, large non-axisymmetric MRI-amplified shearing wave modes, mediated by the axisymmetric azimuthal magnetic field, generate and sustain the large-scale vertical magnetic field through their non-linear interactions. We identify the advection of magnetic loops as a crucial feature, transporting the large-scale vertical magnetic field from the outer regions to the inner regions of the accretion disc. This leads to a larger characteristic size of the, now advected, magnetic field when compared to the local disc height. We characterize the complete dynamo mechanism with two time-scales: one for the local magnetic field generation, $t_{\rm gen}$, and one for the large-scale scale advection, $t_{\rm adv}$. Whereas the dynamo we describe is non-linear, we explore the potential of linear mean field models to replicate its core features. Our findings indicate that traditional $\alpha$-dynamo models, often computed in stratified shearing box simulations, are inadequate and that the effective large-scale dynamics is better described by the shear current effects or stochastic $\alpha$-dynamos.
The AstroSat UV deep field north: direct determination of the UV luminosity function and its evolution from z ~ 0.8–0.4
Authors: Bhattacharya Souradeep , Saha Kanak , Mondal Chayan 
Published: June 2024

ABSTRACT
We characterize the evolution of the rest-frame 1500 Å UV luminosity function (UVLF) from AstroSat/UVIT F154W and N242W imaging in the Great Observatories Origins Survey North (GOODS-N) field. With deep FUV observations, we construct the UVLF for galaxies at z$\lt 0.13$ and subsequently characterize it with a Schechter function fit. The fitted parameters are consistent with previous determinations. With deep NUV observations, we are able to construct the UVLF in seven redshift bins in the range z$\sim$0.4–0.8, with galaxies identified till $\sim$2 mag fainter than previous surveys, owing to the high angular-resolution of UVIT. The fitted Schechter function parameters are obtained for these UVLFs. At z$\sim$0.7–0.8, we also utilize Hubble Space Telescope (HST) F275W observations in the GOODS-N field to construct the UVLF in 2 redshift bins, whose fitted Schechter function parameters are then found to be consistent with that determined from UVIT at z$\sim$0.75. We thus probe the variation of the fitted UVLF parameters over z$\sim$0.8–0.4, a span of $\sim$2.7 Gyr in age. We find that the slope of the Schechter function, $\alpha$, is at its steepest at z$\sim$0.65, implying highest star-formation at this instant with galaxies being relatively more passive before and after this time. We infer that this is a short-lived instance of increased cosmic star-formation in the GOODS-N field even though cosmic star-formation may be winding-down over longer time-span at this redshift range.
Chemical evolution of complex organic molecules in turbulent protoplanetary discs: effect of stochastic ultraviolet irradiation
Authors: Suzuki T , Furuya K , Aikawa Y , Shibata T , Majumdar L 
Published: June 2024

ABSTRACT
We investigate the chemical evolution of complex organic molecules (COMs) in turbulent discs using gas-ice chemical reaction network simulations. We trace trajectories of dust particles considering advection, turbulent diffusion, gas drag, and vertical settling, for 10$^6$ yr in a protoplanetary disc. Then, we solve a gas-ice chemical reaction network along the trajectories and obtain the temporal evolution of molecular abundances. We find that the COM abundances in particles can differ by more than two orders of magnitude even when the ultraviolet (UV) fluence (i.e. the time integral of UV flux) received by the particles are similar, suggesting that not only the UV fluence but also the time variation of the UV flux does matter for the evolution of COMs in discs. The impact of UV fluence on molecular abundances differs between oxygen-bearing and nitrogen-bearing COMs. While higher UV fluence results in oxygen being locked into CO$_2$, leading to reduced abundances of oxygen-bearing COMs such as CH$_3$OCH$_3$, mild UV exposure can promote their formation by supplying the precursor radicals. On the other hand, nitrogen is not locked up into specific molecules, allowing the formation of nitrogen-bearing COMs, particularly CH$_3$NH$_2$, even for the particle that receives the higher UV fluence. We also find that the final COM abundances are mostly determined by the inherited abundances from the protostellar core when the UV fluence received by dust particles is less than a critical value, while they are set by both the inherited abundances and the chemistry inside the disc at higher UV fluence.
Diagnostics of 3D explosion asymmetries of stripped-envelope supernovae by nebular line profiles
Authors: van Baal Bart F A , Jerkstrand Anders , Wongwathanarat Annop , Janka Hans-Thomas 
Published: June 2024

ABSTRACT
Understanding the explosion mechanism and hydrodynamic evolution of core-collapse supernovae (SNe) is a long-standing quest in astronomy. The asymmetries caused by the explosion are encoded into the line profiles which appear in the nebular phase of the SN evolution – with particularly clean imprints in He star explosions. Here, we carry out nine different supernova simulations of He-core progenitors, exploding them in 3D with parametrically varied neutrino luminosities using the prometheus-hotb code, hydrodynamically evolving the models to the homologous phase. We then compute nebular phase spectra with the 3D Non-Local Thermodynamic Equilibrium spectral synthesis code extrass (EXplosive TRAnsient Spectral Simulator). We study how line widths and shifts depend on progenitor mass, explosion energy, and viewing angle. We compare the predicted line profile properties against a large set of Type Ib observations, and discuss the degree to which current neutrino-driven explosions can match observationally inferred asymmetries. With self-consistent 3D modelling – circumventing the difficulties of representing $^{56}$Ni mixing and clumping accurately in 1D models – we find that neither low-mass He cores exploding with high energies nor high-mass cores exploding with low energies contribute to the Type Ib SN population. Models which have line profile widths in agreement with this population give sufficiently large centroid shifts for calcium emission lines. Calcium is more strongly affected by explosion asymmetries connected to the neutron star kicks than oxygen and magnesium. Lastly, we turn to the near-infrared spectra from our models to investigate the potential of using this regime to look for the presence of He in the nebular phase.
The variable stars in the field of the bulge cluster NGC 6558
Authors: Ferro A Arellano , Guillen L J Zerpa , Yepez M A , Fierro I H Bustos , Prudil Z , Parra C E Pérez 
Published: June 2024

ABSTRACT
We made a survey of the variable stars in a 13.2 × 13.2 arcmin$^{2}$ centred on the field of the Galactic bulge cluster NGC 6558. A total of 78 variables were found in the field of the cluster. Many of these variables are included in the catalogue of variable stars in Galactic globular clusters (Clement et al. 2001), OGLE or Gaia DR3 data releases. A membership analysis based on the proper motions of Gaia DR3 revealed that many of these variables do not belong to the cluster. We employed the data from the aforementioned surveys and our own data in the VI photometric system to estimate the periods, which along with the light-curves morphology and position in a deferentially dereddened colour–magnitude diagram (CMD), help classifying the variable types. Two new member variables were found; an eclipsing binary (V18) and a semiregular SR/L (V19). In the end, we conclude that only nine variables are likely cluster members. Member variables were used to discuss the mean metallicity and distance of the parental cluster and find the average values.
TMPyP binding evokes a complex, tunable nanomechanical response in DNA
Authors: Kretzer Balázs , Herényi Levente , Csík Gabriella , Supala Eszter , Orosz Ádám , Tordai Hedvig , Kiss Bálint , Kellermayer Miklós 
Published: June 2024

Abstract
TMPyP is a porphyrin capable of DNA binding and used in photodynamic therapy and G-quadruplex stabilization. Despite its broad applications, TMPyP’s effect on DNA nanomechanics is unknown. Here we investigated, by manipulating λ-phage DNA with optical tweezers combined with microfluidics in equilibrium and perturbation kinetic experiments, how TMPyP influences DNA nanomechanics across wide ranges of TMPyP concentration (5–5120 nM), mechanical force (0–100 pN), NaCl concentration (0.01–1 M) and pulling rate (0.2–20 μm/s). Complex responses were recorded, for the analysis of which we introduced a simple mathematical model. TMPyP binding, which is a highly dynamic process, leads to dsDNA lengthening and softening. dsDNA stability increased at low (&lt;10 nM) TMPyP concentrations, then decreased progressively upon increasing TMPyP concentration. Overstretch cooperativity decreased, due most likely to mechanical roadblocks of ssDNA-bound TMPyP. TMPyP binding increased ssDNA’s contour length. The addition of NaCl at high (1 M) concentration competed with the TMPyP-evoked nanomechanical changes. Because the largest amplitude of the changes is induced by the pharmacologically relevant TMPyP concentration range, this porphyrin derivative may be used to tune DNA’s structure and properties, hence control the wide array of biomolecular DNA-dependent processes including replication, transcription, condensation and repair.
A RAD18–UBC13–PALB2–RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells
Authors: Cybulla Emily , Wallace Sierra , Meroni Alice , Jackson Jessica , Agashe Sumedha , Tennakoon Mithila , Limbu Mangsi , Quinet Annabel , Lomonosova Elena , Noia Hollie , Tirman Stephanie , Wood Matthew , Lemacon Delphine , Fuh Katherine , Zou Lee , Vindigni Alessandro 
Published: June 2024

Abstract
BRCA1/2 proteins function in genome stability by promoting repair of double-stranded DNA breaks through homologous recombination and by protecting stalled replication forks from nucleolytic degradation. In BRCA1/2-deficient cancer cells, extensively degraded replication forks can be rescued through distinct fork recovery mechanisms that also promote cell survival. Here, we identified a novel pathway mediated by the E3 ubiquitin ligase RAD18, the E2-conjugating enzyme UBC13, the recombination factor PALB2, the E3 ubiquitin ligase RNF168 and PCNA ubiquitination that promotes fork recovery in BRCA1- but not BRCA2-deficient cells. We show that this pathway does not promote fork recovery by preventing replication fork reversal and degradation in BRCA1-deficient cells. We propose a mechanism whereby the RAD18–UBC13–PALB2–RNF168 axis facilitates resumption of DNA synthesis by promoting re-annealing of the complementary single-stranded template strands of the extensively degraded forks, thereby allowing re-establishment of a functional replication fork. We also provide preliminary evidence for the potential clinical relevance of this novel fork recovery pathway in BRCA1-mutated cancers, as RAD18 is over-expressed in BRCA1-deficient cancers, and RAD18 loss compromises cell viability in BRCA1-deficient cancer cells.
Acute kidney injury in acute heart failure–when to worry and when not to worry?
Authors: Banerjee Debasish , Ali Mahrukh Ayesha , Wang Angela Yee-Moon , Jha Vivekanand 
Published: June 2024

ABSTRACT
Acute kidney injury is common in patients with acute decompensated heart failure. It is more common in patients with acute heart failure who suffer from chronic kidney disease. Worsening renal function is often defined as a rise in serum creatinine of more than 0.3 mg/dL (26.5 µmol/L) which, by definition, is acute kidney injury (AKI) stage 1. Perhaps the term AKI is more appropriate than worsening renal function as it is used universally by nephrologists, internists and other medical practitioners. In health, the heart and the kidney support each other to maintain the body's homeostasis. In disease, the heart and the kidney can adversely affect each other's function, causing further clinical deterioration. In patients presenting with acute heart failure and fluid overload, therapy with diuretics for decongestion often causes a rise in serum creatinine and AKI. However, in the longer term the decongestion improves survival and prevents hospital admissions despite rising serum creatinine and AKI. It is important to realize that renal venous congestion due to increased right-sided heart pressures in acute heart failure is a major cause of kidney dysfunction and hence decongestion therapy improves kidney function in the longer term. This review provides a perspective on the acceptable AKI with decongestion therapy, which is associated with improved survival, as opposed to AKI due to tubular injury related to sepsis or nephrotoxic drugs, which is associated with poor survival.
Detecting biomarkers by dynamic nuclear polarization enhanced magnetic resonance
Authors: Chen Shizhen , Zhang Lei , Li Sha , Yuan Yaping , Jiang Bin , Jiang Zhongxing , Zhang Xu , Zhou Xin , Liu Maili 
Published: June 2024

ABSTRACT
Hyperpolarization stands out as a technique capable of significantly enhancing the sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Dynamic nuclear polarization (DNP), among various hyperpolarization methods, has gained prominence for its efficacy in real-time monitoring of metabolism and physiology. By administering a hyperpolarized substrate through dissolution DNP (dDNP), the biodistribution and metabolic changes of the DNP agent can be visualized spatiotemporally. This approach proves to be a distinctive and invaluable tool for non-invasively studying cellular metabolism in vivo, particularly in animal models. Biomarkers play a pivotal role in influencing the growth and metastasis of tumor cells by closely interacting with them, and accordingly detecting pathological alterations of these biomarkers is crucial for disease diagnosis and therapy. In recent years, a range of hyperpolarized DNP molecular bioresponsive agents utilizing various nuclei, such as 13C, 15N, 31P, 89Y, etc., have been developed. In this context, we explore how these magnetic resonance signals of nuclear spins enhanced by DNP respond to biomarkers, including pH, metal ions, enzymes, or redox processes. This review aims to offer insights into the design principles of responsive DNP agents, target selection, and the mechanisms of action for imaging. Such discussions aim to propel the future development and application of DNP-based biomedical imaging agents.
CELLULOSE SYNTHASE-LIKE C proteins modulate cell wall establishment during ethylene-mediated root growth inhibition in rice
Authors: Zhou Yang , Gao Yi-Hong , Zhang Bao-Cai , Yang Han-Lei , Tian Yan-Bao , Huang Yi-Hua , Yin Cui-Cui , Tao Jian-Jun , Wei Wei , Zhang Wan-Ke , Chen Shou-Yi , Zhou Yi-Hua , Zhang Jin-Song 
Published: June 2024

Abstract
The cell wall shapes plant cell morphogenesis and affects the plasticity of organ growth. However, the way in which cell wall establishment is regulated by ethylene remains largely elusive. Here, by analyzing cell wall patterns, cell wall composition and gene expression in rice (Oryza sativa, L.) roots, we found that ethylene induces cell wall thickening and the expression of cell wall synthesis-related genes, including CELLULOSE SYNTHASE-LIKE C1, 2, 7, 9, 10 (OsCSLC1, 2, 7, 9, 10) and CELLULOSE SYNTHASE A3, 4, 7, 9 (OsCESA3, 4, 7, 9). Overexpression and mutant analyses revealed that OsCSLC2 and its homologs function in ethylene-mediated induction of xyloglucan biosynthesis mainly in the cell wall of root epidermal cells. Moreover, OsCESA-catalyzed cellulose deposition in the cell wall was enhanced by ethylene. OsCSLC-mediated xyloglucan biosynthesis likely plays an important role in restricting cell wall extension and cell elongation during the ethylene response in rice roots. Genetically, OsCSLC2 acts downstream of ETHYLENE-INSENSITIVE3-LIKE1 (OsEIL1)-mediated ethylene signaling, and OsCSLC1, 2, 7, 9 are directly activated by OsEIL1. Furthermore, the auxin signaling pathway is synergistically involved in these regulatory processes. These findings link plant hormone signaling with cell wall establishment, broadening our understanding of root growth plasticity in rice and other crops.
Lateral atlanto-axial joint access using the C2 pedicle
Authors: Zarembinski Christopher , Wright Robert 
Published: June 2024

Abstract

Background
Neck pain and headaches can arise from the lateral atlanto-axial (LAA) joint. This pain can be diagnosed with intra-articular injections of local anesthetic. A widely used technique for access to the lateral atlanto-axial joint uses a posterior approach, but this approach can be hazardous because of the proximity of the vertebral artery, the dural sac, and the C2 spinal nerve and dorsal root ganglion.

Objective
The objective was to describe and test a new technique for accessing the LAA joint that avoids structures that lie behind the joint.

Interventions
The new technique was described and tested for tolerance in 10 patients with unilateral suboccipital pain and tenderness over the LAA joint, along with evidence of LAA joint arthropathy on SPECT CT. The technique requires inserting a needle along a trajectory tangential to the dorsal surface of the C2 lamina. It involves obtaining a declined view of the C2 lamina and C2 pedicle.

Conclusions
In all cases, the C2 pedicle was easily identified and allowed the needle to pass asymptomatically underneath the neurovascular structures behind the joint. The tactile response of the lamina of C2 provided important feedback regarding needle depth caudal to the LAA joint.
Numeric social-media posts engage people with climate science
Authors: Peters Ellen , Markowitz David M , Nadratowski Ariel , Shoots-Reinhard Brittany 
Published: June 2024

Abstract
Innumeracy (lack of math skills) among nonscientists often leads climate scientists and others to avoid communicating numbers due to concerns that the public will not understand them and may disengage. However, people often report preferring to receive numbers; providing them also can improve decisions. Here, we demonstrated that the presence vs. absence of at least one Arabic integer in climate-related social-media posts increased sharing up to 31.7% but, counter to hypothesis, decreased liking of messages 5.2% in two preregistered observational studies (climate scientists on Twitter, N &gt; 8 million Tweets; climate subreddit, N &gt; 17,000 posts and comments). We speculated that the decreased liking was due, not to reduced engagement, but to more negative feelings towards climate-related content described with numeric precision. A preregistered within-participant experiment (N = 212) then varied whether climate consequences were described using Arabic integers (e.g. “90%”) or another format (e.g. verbal terms, “almost all”). The presence of Arabic integers about consequences led to more sharing, wanting to find out more, and greater trust and perceptions of an expert messenger; perceived trust and expertise appeared to mediate effects on sharing and wanting to find out more. Arabic integers about consequences again led to more negative feelings about the Tweets as if numbers clarified the dismaying magnitude of climate threats. Our results indicate that harnessing the power of numbers could increase public trust and concern regarding this defining issue of our time. Communicators, however, should also consider counteracting associated negative feelings—that could halt action—by providing feasible solutions to increase people's self-efficacy.