bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of clinical outcomes in heart failure patients with and without advanced chronic kidney disease
Authors: Zahir Anjum Deewa , Bonde Anders N. , Fosbol Emil , Hartwell Garred Caroline , Gislason Gunnar , Elmegaard Mariam , Knigge Pauline , Torp‐Pedersen Christian , Andersson Charlotte , Pfeffer Marc A. , Jhund Pardeep S. , McMurray John J.V. , Petrie Mark C. , Kober Lars , Schou Morten 
Published: July 2024

AbstractAimsChronic kidney disease (CKD) is a well‐established risk factor for heart failure (HF); however, patients with an estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 have been systematically excluded from clinical trials. This study investigated the incidence of HF and kidney outcomes in HF patients with and without advanced CKD, that is, eGFR < 30.MethodsFrom nationwide registries, HF patients were identified from 2014 to 2018 and categorized into three groups according to baseline eGFR (eGFR ≥ 60, 60 > eGFR ≥ 30 and eGFR < 30). The incidence of primary outcomes (all‐cause mortality, HF hospitalization, end‐stage kidney disease and sustained 50% eGFR decline) was estimated using cumulative incidence functions.ResultsOf the 21 959 HF patients included, the median age was 73.9 years, and 30% of patients had an eGFR between 30 and 60 and 7% had an eGFR < 30. The 4 year incidence of all‐cause mortality was highest for patients with eGFR < 30 (28.3% for patients with eGFR ≥ 60, 51.6% for patients with 60 > eGFR ≥ 30 and 72.2% for patients with eGFR < 30). The 4 year incidence of HF hospitalization was comparable between the groups (25.8%, 29.8% and 26.1% for patients with eGFR ≥ 60, 60 > eGFR ≥ 30 and eGFR < 30, respectively). For patients with eGFR < 30, kidney outcomes were four times more often the first event than patients with eGFR > 30 (4 year incidence of kidney outcome as the first event was 5.0% for eGFR ≥ 60, 4.8% for 60 > eGFR ≥ 30 and 20.1% for eGFR < 30).ConclusionsPatients with advanced CKD had a higher incidence of mortality and poorer kidney outcomes than those without advanced CKD, but a similar incidence of HF hospitalizations.
Regulation of IFN‐γ production by ZFP36L2 in T cells is time‐dependent
Authors: Zandhuis Nordin D. , Guislain Aurélie , Popalzij Abeera , Engels Sander , Popović Branka , Turner Martin , Wolkers Monika C. 
Published: July 2024

AbstractCD8+ T cells kill target cells by releasing cytotoxic molecules and proinflammatory cytokines, such as TNF and IFN‐γ. The magnitude and duration of cytokine production are defined by posttranscriptional regulation, and critical regulator herein are RNA‐binding proteins (RBPs). Although the functional importance of RBPs in regulating cytokine production is established, the kinetics and mode of action through which RBPs control cytokine production are not well understood. Previously, we showed that the RBP ZFP36L2 blocks the translation of preformed cytokine encoding mRNA in quiescent memory T cells. Here, we uncover that ZFP36L2 regulates cytokine production in a time‐dependent manner. T cell‐specific deletion of ZFP36L2 (CD4‐cre) had no effect on T‐cell development or cytokine production during early time points (2–6 h) of T‐cell activation. In contrast, ZFP36L2 specifically dampened the production of IFN‐γ during prolonged T‐cell activation (20–48 h). ZFP36L2 deficiency also resulted in increased production of IFN‐γ production in tumor‐infiltrating T cells that are chronically exposed to antigens. Mechanistically, ZFP36L2 regulates IFN‐γ production at late time points of activation by destabilizing Ifng mRNA in an AU‐rich element‐dependent manner. Together, our results reveal that ZFP36L2 employs different regulatory nodules in effector and memory T cells to regulate cytokine production.
Organotellurium(II) and ‐(IV) Compounds with Picolinoylbis(thioureas): From Simple 1 : 1 Adducts to Multimetallic Aggregates
Authors: dos Santos Sailer S. , Schwade Vania D. , Lang Ernesto Schulz , Pham Chien Thang , Roca Jungfer Maximilian , Abram Ulrich , Nguyen Hung Huy 
Published: July 2024

AbstractReactions of 2,6‐dipicolinoylbis(N,N‐diethylthiourea) (H2LEt) with common tellurium(IV) starting materials such as PhTeBr3 or TeBr4 yield various tellurium(IV) and tellurium(II) compounds depending on the conditions applied. Equimolar amounts of H2LEt and PhTeBr3 give the 1 : 1 complex [PhTeIVBr3(H2LEt)], while with an excess of H2LEt, the tellurium compound is partially reduced and a {PhTeII}+ building block coordinates to both sulfur atoms of H2LEt under the formation of the ion pair [PhTeII(H2LEt)][PhTeIVBr4]. Similar reactions between H2LEt and TeBr4 give the neutral monomer [TeIIBr2(H2LEt)] or the coordination polymer [TeIIBr2(H2LEt)]∞. The latter compound is also formed with the assistance of Pb2+ ions. While the lead ions do not appear in the isolated product, similar reactions with transition metal ions such as Ni2+, Mn2+, or Co2+ result in the formation of heterobimetallic complexes, in which Te(II) building blocks are directed to the sulfur atoms of the deprotonated ligand {H2LEt2‐S,S}2−, while the transition metal ions occupy central coordination positions between two of the organic ligands using the pyridine nitrogen atom, carbonyl oxygen atom(s) and/or the nitrogen atoms of the thiourea units.
Trapping Highly Reactive Metal(H)2(η2‐H2) Species to Form Trihydride Complexes and Clusters
Authors: Tickner Ben. J. , Whitwood Adrian C. , Condon Claire , Platas‐Iglesias Carlos , Duckett Simon B. 
Published: July 2024

AbstractMetal dihydride dihydrogen‐derived intermediates can be short‐lived and difficult to detect despite their ubiquitous role in chemical transformations such as hydrogenation. Here, highly reactive [Ir(H)3(η2‐η2‐COD)(IMes)] forms by trapping [Ir(H)2(η2‐H2)(η2‐η2‐COD)(IMes)]X [X=Cl or MeO], resulting from reaction of the Ir(I) precatalyst [IrCl(η2‐η2‐COD)(IMes)] with a base and H2. This trihydride allows access to the unusual [Ir2(H)4(OMe)(IMes)2(pyridine)3]X, [Ir2(H)2(μ2‐H)2(η2‐η2‐COD)(IMes)2], [Ir3(H)9(IMes)3], [Ir4(H)12(IMes)4] and [Ir2(H)4(μ2‐H)2(IMes)2(pyridine)2]. A combination of 2D NMR, parahydrogen hyperpolarized NMR, MS, and XRD are used to characterise these reaction products and rationalise their formation via the moiety {Ir(H)3(IMes)}. Consequently, the results of these studies have implications for iridium‐catalyzed polarization transfer from parahydrogen via the well‐known precursor [IrCl(η2‐η2‐COD)(IMes)].
Quantifying the impacts of climate change and human activities on runoff and suspended sediment load in the Lhasa River Basin, Tibetan Plateau
Authors: Zhang Wenduo , Zhao Dongmei , Zhang Baojun , Xiong Donghong , Liu Lin , Qin Xiaomin , Rai Dil Kumar , Laraib Sheikh , Wang Xiaodan , Deng Wei 
Published: July 2024

AbstractQuantifying the attribution of climate change and human activities on runoff and suspended sediment load is crucial for formulating future watershed management measures, especially in the ecologically fragile alpine region, which is more susceptible to climate change and human activities. In this study, the temporal changes in runoff‐suspended sediment load and the potential impact factors (i.e., precipitation, potential evapotranspiration (PET), land use/land cover change (LULC) and reservoir operation) were investigated in the Lhasa River Basin (LRB) from 1956 to 2020. In addition, the contributions of those factors to the changes in runoff and suspended sediment load were quantitatively evaluated based on physically‐based Soil and Water Assessment Tools (SWAT). The results indicated that annual runoff and suspended sediment load showed an increasing but insignificant trend during 1956–2020, while annual precipitation and PET showed a significant increasing trend at a rate of 0.94 and 1.07 mm/yr, respectively. LULC mainly presented an increase in forestland area followed by a decrease in grassland and bare land area due to the implementation of ecological projects. Runoff and suspended sediment load changed abruptly at approximately 1995 and 2005 based on three abrupt change identification methods, thus, the study period was further divided into three substages: baseline period (P0, 1956–1994), dramatically increased period (P1, 1995–2004) and slightly decreased period (P2, 2005–2020). The attribution analysis showed that climate change was the dominant contributor to runoff and suspended sediment load increments during P1. LULC caused the decline in runoff and suspended sediment load in both P1 and P2, with their contribution increasing significantly from 0.40% and 4.73% in P1 to 50.24% and 51.79% in P2, respectively. Reservoir operation was the second key factor in runoff and suspended sediment load reduction in P2, contributing 42.07% and 43.72%, respectively. These findings provide the scientific foundation for reasonably allocating water resources and statistical support for the benefit evaluation of implementing ecological projects in the basin.
Reproductive Capacity, but not Food Consumption, is Reduced by Continuous Exposure to Typical Genotoxic Stressor γ-Rays in the sentinel species Gammarus fossarum
Authors: Frelon Sandrine , Recoura-Massaquant Rémi , Dubourg Nicolas , Garnero Laura , Bonzom Jean-Marc , Degli-Esposti Davide 
Published: July 2024

Abstract
The long-term impacts of radiocontaminants (and the associated risks) for ecosystems are still subject to vast societal and scientific debate while wildlife is chronically exposed to various sources and levels of either environmental or anthropogenic ionizing radiation from the use of nuclear energy. The present study aimed to assess induced phenotypical responses in both male and female gammarids after short-term continuous γ-irradiation, acting as a typical well-characterized genotoxic stressor that can interact directly with living matter. In particular, we started characterizing the effects using standardized measurements for biological effects on few biological functions for this species, especially feeding inhibition tests, molting, and reproductive ability, which have already been proven for chemical substances and are likely to be disturbed by ionizing radiation. The results show no significant differences in terms of the survival of organisms (males and females), of their short-term food consumption which is linked to the general health status (males and females), and of the molting cycle (females). In contrast, exposure significantly affected fecundity (number of embryos produced) at the highest dose rates for irradiated females (51 mGy h–1) and males (5 and 51 mGy h–1). These results showed that, in gammarids, reproduction, which is a critical endpoint for population dynamics, is the most radiosensitive phenotypic endpoint, with significant effects recorded on male reproductive capacity, which is more sensitive than in females. Environ Toxicol Chem 2024;43:2071–2079. © 2024 SETAC
Real‐time mildew detection and gradation in simulated containerized soybeans: Insights from GC‐IMS analysis of mVOCs and VOCs
Authors: Song Xuejian , Qian Lili , Fu Lixue , Cao Rongan , Wang Xinhui , Chen Mingming 
Published: July 2024

AbstractIn the context of bulk grain container transportation, the complex logistics can lead to grain mildew and subsequent economic losses. Therefore, there is a pressing need to explore swift and real‐time mildew detection technology. Our investigation, simulating actual transportation conditions, revealed that Aspergillus, Penicillium, and Rhizopus were the primary molds responsible for soybean mildew during container transportation. Utilizing gas chromatography‐ion migration spectroscopy (GC‐IMS), we analyzed the correlation between the mVOCs (microbial volatile organic compounds) produced by dominant mold and the VOCs emitted during soybean mildew. Principal Component Analysis (PCA) and clustering results demonstrated the distinctive identification of VOCs in soybeans with varying degrees of mildew. The mildew degree significantly influenced the content variation of VOCs. As the mildew degree increased, the concentrations of nonanal, octanal, etc. progressively decreased, contrasting with the rising levels of phenylacetaldehyde, 3‐methyl‐2‐butenal, etc. Therefore, the combination of GC‐IMS with chemometrics proves to be a viable method for identifying the mildew degree of soybeans. Therefore, this study underscores the importance of implementing effective mildew detection techniques in the challenging context of bulk grain container transportation.
Garlic peel extract as an antioxidant inhibits triple‐negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase‐2 expression
Authors: Dong Yushi , Zhang Jiyue , Xie Aijun , Yue Xiqing , Li Mohan , Zhou Qian 
Published: July 2024

AbstractGarlic peels are frequently disposed of as agro‐waste; their bioactivity and physiological activity for health benefits and disease protection are neglected. This study aims to examine the potential inhibitory effects of garlic peel extract as an antioxidant on 4 T1 triple‐negative breast cancer (TNBC) tumors in mice. The bioactive constituents of garlic peel were identified through HPLC‐MS/MS analysis, while the antioxidant properties of garlic peel extract were assessed using peroxyl radical scavenging capacity (PSC) and cellular antioxidant activity (CAA) assays. Subsequently, the inhibitory effects of garlic peel extract on 4T1 tumor growth were evaluated using a 4T1 model. The results showed that 433 polyphenol compounds were found in garlic peel extract; among them, flavonoids and phenolic acid are the primary polyphenols with natural antioxidant activity, and both high and low concentrations of the extract exhibited tumor‐suppressive effects. Immunohistochemistry was employed to assess the expression levels of COX‐2, CD31, VEGFA, MMP2, and MMP9 in tumor tissues in order to investigate the antioxidant properties of garlic peel extract, specifically its ability to suppress COX‐2 expression. The findings of this study offer a foundation for the advancement of garlic peel‐based functional products and contribute to the identification of potential anti‐cancer agents and therapeutic targets.
Potential of miRNA as Imaging Targets for PET
Authors: Zientek Simon H. , Thompson Stephen , Aigbirhio Franklin I. , Sephton Selena Milicevic 
Published: July 2024

AbstractPositron Emission Tomography (PET) is an important part of the medical imaging field which is continually exploring novel biological targets as exemplified by PET imaging of neuroinflammation. Due to limitations stemming from either sub‐optimal biological targets or a lack of available selective radiotracers, alternative biomarkers and PET imaging agent candidates are considered. One such possible target is microRNA (miRNA) and herein, we discuss the potential of miRNA for PET imaging. With the aim of addressing key strategies for imaging miRNA with PET, we identify three distinct approaches as follows: small molecules directly targeting miRNA, small molecules indirectly targeting Argonaute 2 (AGO2)‐protein complexes, and direct chemical modification of antisense oligonucleotides. The radiosynthetic approaches are based on the methods of direct radiolabelling of respective antisense oligonucleotides and several examples are described herein, showcasing the potential of miRNA in PET imaging. Whilst these approaches offer different radiolabelling strategies, application of these radiolabelled molecules towards PET imaging of miRNA are scarce with only one, limited example applied to bone remodeling reported in the literature.
Changes in snow water storage and hydrologic partitioning in an alpine catchment in the Colorado Front Range
Authors: Hale Katherine E. , Musselman Keith N. , Bjarke Nels R. , Livneh Ben , Hinckley Eve‐Lyn S. , Molotch Noah P. 
Published: July 2024

AbstractAs the climate warms, snow‐dominated regions are increasingly susceptible to precipitation phase changes and earlier snowmelt. In alpine catchments, snowmelt is the majority of runoff, governed by heterogeneous interactions among snowfall, wind, topography and vegetation. The role of the alpine snowpack in delaying the downstream release of accumulated snowfall remains understudied, despite its fundamental role in sustaining lower‐elevation ecosystems and populations. We evaluated fine‐scale changes in the magnitude and duration of alpine snow water storage and release by comparing effective precipitation seasonality to that of surface water inputs using a Snow Storage Index (SSI). We forced the Distributed Hydrology Soil Vegetation Model with historical climate conditions and an end‐of‐century warming signal down‐scaled from a 4‐km regional climate model, to simulate future changes in snow water storage and partitioning of precipitation to runoff and evapotranspiration. The hydrological modelling was conducted on a 2‐m spatial grid to resolve fine scale processes over a 0.6‐km2 headwater catchment within the Niwot Ridge Long‐Term Ecological Research site located in the Rocky Mountains, Colorado, USA. Proportionally more rainfall, reduced snowpack size and extent, and earlier snowmelt occurred in the future scenario with decreased catchment average SSI and thus snow water storing capabilities, with inordinately large decreases occurring in areas of the catchment with reconstructed snowdrifts (−57% average and −100% maximum). Using the Budyko framework to evaluate annual hydrologic partitioning, precipitation inputs to streamflow increased by a maximum 10% in large SSI regions with snowdrifts under warming conditions, signifying a potential buffer for total catchment and annual streamflow loss in a future climate. The fine‐scale analysis of hydrologic sensitivities to warming presented herein are important because climate conditions are expected to further reduce alpine snow water storage, alter hydrologic partitioning, and runoff generation for ecosystems and people living downstream.
Quantification of enrichment processes in throughfall and stemflow in a mixed temperate forest
Authors: Grundmann Maria H. , Molnar Peter , Floriancic Marius G. 
Published: July 2024

AbstractForest ecosystems depend on throughfall and stemflow fluxes for both water and nutrient input. Spatial and temporal variability of throughfall and stemflow fluxes are large and differ between tree species. The nutrient fluxes that accompany throughfall and stemflow are affected by climate, precipitation intensity, the seasonality of dry deposition, and canopy exchange processes. The interdependence of these factors makes it challenging to quantify changes in throughfall and stemflow amounts as well as their nutrient content. Here, we provide observation‐based evidence from 3.5 years of data collection with 222 rainfall events, of the seasonal variability of throughfall and stemflow magnitude and ion concentrations under a beech (Fagus silvatica) and spruce (Picea abies) tree. Interception and canopy cover were seasonally variable, average annual interception was 53% below beech, 61% below spruce and 68% below young spruce canopies. Further, we assess seasonality of ionic nutrients such as NH4 and NO3 as well as Mg, Ca and K and their dependence on both dry deposition and canopy exchange. Throughfall and stemflow were enriched compared to precipitation, with large differences between ions and different months. Antecedent precipitation was a main control on throughfall and stemflow enrichment. We developed a conceptual model of the potential drivers of throughfall and stemflow enrichment based on our observations. While NH4 and NO3 enrichment are likely dominated by dry deposition and dew and fog accumulation, Mg, Ca and K were additionally affected by canopy exchange. Observation based studies such as this one are needed to understand precipitation and nutrient partitioning across forests, which enables the prediction of how changes in climate and forest composition will affect local hydrology and nutrient inputs into forest ecosystems.
Formative drought rate to quantify propagation from meteorological to hydrological drought
Authors: Yildirim Isilsu , Aksoy Hafzullah , Hrachowitz Markus 
Published: July 2024

AbstractIn this study, we propose a probabilistic metric, the formative drought rate (FDR), to quantify drought propagation. It is the probability that a meteorological drought in precipitation forms a hydrological drought in streamflow. Drought events were identified based on the standardized precipitation index and streamflow drought index, respectively, at 1‐, 3‐, 6‐ and 12‐month timescales. The method was tested in three river basins in Turkey (Kucuk Menderes, Gediz and Ergene). In each river basin, meteorological stations were coupled with streamflow gauging stations to form pairs of stations depending on their distance from each other and the length of their common record periods. The FDR was calculated across all timescales for each pair of stations. It was found capable to describe the river basin‐specific spatial and temporal variability of drought propagation. As the FDR is defined in the form of probability, it is expected to be a useful metric for quantifying propagation from meteorological to hydrological drought. Thus, it carries a potential for scientific research and practice in water resources management.
River–aquifer interactions enhancing evapotranspiration in a semiarid riparian zone: A modelling study
Authors: Zhu Bowen , Huang Maoyi , Chen Xingyuan , Bisht Gautam , Shuai Pin , Xie Xianhong 
Published: July 2024

AbstractThe hydrologic flows across the river–aquifer interface play an important role in groundwater dynamics and biogeochemical reactions within the subsurface; however, little is known about the effects of river–aquifer interactions on land surface processes. In this study, we developed a fully coupled three‐dimensional (3D) land surface and subsurface model at a high resolution (~1 km) that accounts for high‐frequency hydrologic exchange flow conditions to investigate how river–aquifer interactions modulate surface water budgets in the Upper Columbia‐Priest Rapids watershed, a typical semiarid watershed located in the northwestern United States where river stage fluctuates in response to reservoir releases changing. Our results show that the spatiotemporal dynamics of river–aquifer interactions are highly heterogeneous, driven mainly by river‐stage fluctuations. Adding 6.64 × 106 m3 year−1 of water over the watershed from the river to groundwater owing to the lateral flow, river–aquifer interactions led to an increase in soil evaporation and transpiration supplied by higher soil moisture content, particularly in deeper subsurface. In a hypothetic future scenarios where a 5‐m rise in river stage was assumed, the hydrologic flow exchange rates were intensified, resulting in higher surface water over the entire watershed. Overall, lateral flow induced by river–aquifer exchanges leads to an increase in evapotranspiration of ~75% in the historical period and of ~83% in the hypothetical future scenario. Our study demonstrates the potential of coupled model as an effective tool for understanding river–aquifer–land surface interactions, and indicates that river–aquifer interactions fundamentally alter the water balance of the riparian zone for the semiarid watershed and will likely become more frequent and intense in the future under the effects of climate change.