bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining firearm-related deaths in Mexico, 2015–2022
Authors: Weigend Vargas Eugenio , Degli Esposti Michelle , Hargarten Stephen , Vargas Laura , Goldstick Jason E. 
Published: July 2024

Abstract
Background
Globally, Mexico is one of six countries with the highest level of firearm mortality. While previous studies have examined firearm mortality in Mexico before 2015, increases in violence since then highlight the need for an updated analysis. In this study, we examined changes in firearm-related deaths in Mexico from 2015 to 2022 and described these deaths by key demographic groups, incident location, and state of occurrence. Data came from Mexico’s Instituto Nacional de Estadistica y Geografia (INEGI), a federal agency that collects and reports national population data. We used descriptive statistics to analyze rates, proportions, and percentage changes in firearm mortality, and we displayed temporal trends using time plots and special trends using maps.

Results
Firearm deaths increased in Mexico from 2015 to 2018 but slightly decreased from 2018 to 2022. Homicides presented the highest increase and the highest proportion of firearm-related deaths from 2015 to 2022. Victims were primarily males but rates among women increased at a higher proportion (99.5% vs 53.5%). One third of victims were 20–29y but rates among children and adolescents (10–9y) increased at a higher proportion. Most firearm-related deaths occurred in streets or public spaces but the percentage of incidents occurring in households have increased. State-level rates and percentage changes varied significantly. States with higher rates of firearm mortality coincide with those involving conflict among organized criminal organizations.

Conclusion
Firearm mortality in Mexico is a major public health burden. The epidemiology of firearm-related deaths in Mexico varies by intent, demographics, location, and states. To mitigate this challenge, multiple solutions are required.
Seabed benchmark system in Aira Caldera
Authors: Tsutsui Tomoki , Miki Daisuke , Iguchi Masato 
Published: July 2024

AbstractThis paper describes the performance of a seabed benchmark system for measuring ground deformation associated with underwater volcanism. The system is installed in the center of the Aira Caldera, Japan, on the caldera floor 30 m below the sea surface. This is the first attempt to directly measure the expected ground deformation within a flooded caldera in Japan. The system consists of an anchor, a universal joint, a rigid steel shaft, a float, and a deck. A global navigation satellite system antenna array, consisting of a primary antenna and auxiliary antennas, is installed at the top of the moving buoy to monitor the position of the benchmark at the caldera bottom. A post-processing procedure is used to reduce the tilt of the master antenna based on measurements made by the auxiliary antennas. The system was installed in March, 2023, and has since been operating successfully with an acceptable measurement standard deviation.
Graphical Abstract
Pelvic lymph node mapping in prostate cancer: examining the impact of PSMA PET/CT on radiotherapy decision-making in patients with node-positive disease
Authors: Furman Ben , Falick Michaeli Tal , Den Robert , Ben Haim Simona , Popovtzer Aron , Wygoda Marc , Blumenfeld Philip 
Published: July 2024

Abstract
Introduction
Prostate Specific Membrane Antigen (PSMA) imaging with Positron Emission Tomography (PET) plays a crucial role in prostate cancer management. However, there is a lack of comprehensive data on how PSMA PET/CT (Computed Tomography) influences radiotherapeutic decisions, particularly in node-positive prostate cancer cases. This study aims to address this gap by evaluating two primary objectives: (1) Mapping the regional and non-regional lymph nodes (LNs) up to the aortic bifurcation and their distribution using conventional methods with CT compared to PSMA PET/CT, and (2) assessing the impact of PSMA PET/CT findings on radiotherapeutic decisions.

Methods
A retrospective analysis of 95 node-positive prostate cancer patients who underwent both CT and PSMA PET/CT imaging prior to primary radiotherapy and androgen deprivation therapy (ADT) was conducted. The analysis focused on identifying LNs in various regions including the common iliac, external iliac, internal iliac, obturator, presacral, mesorectal, inguinal, and other stations. Treatment plans were reviewed for modifications based on PSMA PET/CT findings, and statistical analysis was performed to identify predictors for exclusive nodal positivity on PSMA PET/CT scans.

Results
PSMA PET/CT identified additional positive nodes in 48% of cases, resulting in a staging shift from N0 to N1 in 29% of patients. The most frequent metastatic LNs were located in the external iliac (76 LNs; 34%), internal iliac (43 LNs; 19%), and common iliac (35 LNs; 15%) stations. In patients with nodes only detected on PSMA PET the most common nodes were in the external iliac (27, 40%), internal iliac (13, 19%), obturator (11, 15%) stations. Within the subgroup of 28 patients exclusively demonstrating PSMA PET-detected nodes, changes in radiotherapy treatment fields were implemented in 5 cases (18%), and a dose boost was applied for 23 patients (83%). However, no discernible predictors for exclusive nodal positivity on PSMA PET/CT scans emerged from the analysis.

Discussion
The study underscores the pivotal role of PSMA PET/CT compared to CT alone in accurately staging node-positive prostate cancer and guiding personalized radiotherapy strategies. The routine integration of PSMA PET/CT into diagnostic protocols is advocated to optimize treatment precision and improve patient outcomes.
Minimally invasive pancreaticoduodenectomy for circumportal pancreas: literature review and report of two type IIIA cases
Authors: Imamura Hajime , Adachi Tomohiko , Yamashita Mampei , Kinoshita Ayaka , Hamada Takashi , Matsushima Hajime , Hara Takanobu , Soyama Akihiko , Kobayashi Kazuma , Kanetaka Kengo , Eguchi Susumu 
Published: July 2024

Abstract
Background
Circumportal pancreas is a rare morphological variant with clinical significance due to the high risk of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy. Type IIIA (suprasplenic anteportal) is the most common type of circumportal pancreas. We present two cases of type IIIA treated with minimally invasive pancreaticoduodenectomy, and review the literature on patients with circumportal pancreas who underwent pancreatic surgery.

Case presentation
Case 1: Laparoscopic Pancreaticoduodenectomy for Non-functioning Pancreatic Neuroendocrine Neoplasm with Circumportal Pancreas. A 69-year-old female with no prior medical history presented with a pancreatic head mass detected during routine ultrasound. CT revealed a 20 mm hypervascular tumor in pancreas head and a suprasplenic circumportal pancreas with an anteportal duct. The main pancreatic duct (MPD) was not in the parenchyma on the dorsal side of the portal vein (PV). Laparoscopic pancreaticoduodenectomy was performed. The anteportal side was resected with an ultrasonic device, and the retroportal side with a mesh-reinforced stapler. Pancreaticojejunostomy was performed without complications. Case 2: Robot-assisted Pancreaticoduodenectomy for Pancreatic Head Cancer and Non-functioning Pancreatic Neuroendocrine Neoplasm in the pancreatic tail with Circumportal Pancreas. A 72-year-old male with no prior medical history presented with a dilated main pancreatic duct on ultrasound. Diagnosed with pancreatic head cancer (Stage IIA), he underwent neoadjuvant chemotherapy. Contrast-enhanced CT revealed pancreatic cancer in the head and a tumor in the tail with unknown pathology. Robot-assisted pancreaticoduodenectomy was performed, and pancreatectomy on the left side of the tail tumor was planned. Intraoperative findings revealed a circumportal pancreas with the MPD not running through the dorsal parenchyma. After resected the parenchyma on the left side of the tail tumor, parenchyma on the dorsal side of the PV was dissected using SynchroSeal®. Pancreaticojejunostomy was performed without complications. The postoperative course was uneventful.

Conclusions
The optimal location and method of pancreatic resection should be selected according to the type of circumportal pancreas and the location of the lesion to be resected to minimize the risk of pancreatic fistula. Minimally invasive surgery for circumportal pancreas remains challenging even for surgical teams with sufficient experience and skills, and careful consideration are necessary for its application.
Advanced outcomes of mixed reality usage in orthognathic surgery: a systematic review
Authors: Stevanie Carolina , Ariestiana Yossy Yoanita , Hendra Faqi Nurdiansyah , Anshar Muh , Boffano Paolo , Forouzanfar Tymour , Sukotjo Cortino , Kurniawan Sri Hastuti , Ruslin Muhammad 
Published: July 2024

Abstract
Introduction
Orthognathic surgery (OGS) is a highly sophisticated surgical technique that aims to repair a variety of skeletal and dental abnormalities, including misaligned jaws and teeth. It requires precise preoperative preparation and advanced surgical skills, which are typically learned through years of practical experience in operating rooms or laboratory-based surgical training facilities utilizing cadavers or models. The traditional physical hands-on method of surgical training is still used at OGS. However, this method requires a longer time of preparation. Currently, mixed reality (MR)—a combination of virtual reality and augmented reality technology—is an innovation of OGS. The present study aimed to present a comprehensive review of studies that assessed the advantages of utilizing mixed reality technology in OGS.

Methods
A modified Population, Intervention, Comparison, Outcome strategy was performed using a combination of electronic (PubMed, Cochrane, Embase) and manual searches between 2013 and 2023 exploring mixed reality (MR) technology in OGS in the last 10 years. The inclusion criteria were limited to the patient and study model focusing on the clinical application of MR and the associated field of OGS.

Result
The initial search indicated 1731 studies, of which 17 studies were included for analysis. The main results indicated that the use of MR technology in OGS led to high accuracy and time reduction as primary outcomes and cost-effectiveness and skill improvement as secondary outcomes. The review firmly concluded that MR technology exhibited a positive impact on students, trainees, and oromaxillofacial surgeons. However, due to the heterogeneity of the included studies, meta-analyses could not be performed. Collectively, these findings provide strong evidence for the advantages of MR technology in orthognathic surgery.

Conclusion
MR technology significantly improves OGS planning efficiency by providing pre-surgical information and serving as an intraoperative navigation tool, reducing surgical time without compromising outcomes. Virtual training using MR technology exerts a positive impact on knowledge and skill improvement for OGS. This innovative technology will revolutionize the healthcare system and enhance patient care.
Grammatical structures of emoji in Japanese-language text conversations
Authors: Sekine Kazuki , Ikuta Manaka 
Published: July 2024

AbstractEmojis have become a ubiquitous part of everyday text communication worldwide. Cohn et al. (Cognit Res Princ Implic 4(1):1–18, 2019) studied the grammatical structure of emoji usage among English speakers and found a correlation between the sequence of emojis used and English word order, tending towards an subject–verb–object (SVO) sequence. However, it remains unclear whether emoji usage follows a universal grammar or whether it is influenced by native language grammar. Therefore, this study explored the potential influence of Japanese grammar on emoji usage by Japanese speakers. Twenty adults, all native Japanese speakers, participated in pairs. In Experiment 1, participants engaged in conversations through Google Hangouts on iPads. The experiment consisted of four conversation rounds of approximately 8 min each. The first two rounds involved one participant using only written Japanese and the other using only emojis and punctuation, with roles reversed in the second round. The third round required both participants to use only emojis and punctuation. The results indicated that participants preferred subject–object–verb (SOV) or object–verb (OV) sequences, with OV patterns being more common. This pattern reflects a distinctive attribute of Japanese grammatical structure, marked by the frequent omission of the subject. Experiment 2 substituted emojis for words, showing nouns were more commonly replaced than verbs due to the difficulty in conveying complex meanings. Reduced subject replacements again emphasised Japanese grammatical structure. In essence, emoji usage reflects native language structures, but complexities are challenging to convey, resulting in simplified sequences. This study offers insights for enhancing emoji-based communication and interface design, with implications for translation and broader communication.
An informatics method for inferring the hardening exponent of plasticity in polycrystalline metals from surface strain measurements
Authors: Papanikolaou Stefanos 
Published: July 2024

AbstractThe investigation of strain hardening in metals is complex, with the outcome depending on experimental conditions, that may involve microstructural history, temperature and loading rate. Hardening is commonly measured, after mechanical processing, through controlled mechanical testing, in ways that either distinguish elastic (stress) from total deformation measurements, or by identifying plastic slip contributions. In this paper, we conjecture that hardening effects can be unraveled through statistical analysis of total strain fluctuations during the evolution sequence of profiles, measured in-situ, through digital image correlation. In particular, we hypothesize that the work hardening exponent is related, through a power-law relationship, to a particular exponent arising from principal component analysis. We demonstrate a scaling analysis for synthetic data produced by widely applicable crystal plasticity models for polycrystalline solids.
Graphical Abstract
Abdominal aortic aneurysm complicated by descending thoracic aortic dissection in a patient with TGFBR1 mutation
Authors: Huang Chen , Zhang Wenwen 
Published: July 2024

Abstract
Background
We described a case of abdominal aortic aneurysm complicated by type B thoracic aortic dissection, in whom molecular analysis revealed a pathogenic TGFBR1 missense mutation.

Case presentation
A 36-year-old woman was admitted to our hospital with sudden onset of back pain. Computed tomography angiogram demonstrated descending aortic dissection extending into the abdominal aorta aneurysm. Whole-exome sequencing and subsequent Sanger sequencing confirmed a pathogenic mutation in the TGFBRI gene (NM_004612.4: c.605C > T; p.Ala202Val). She refused to receive surgery and died one month later.

Conclusion
To our knowledge, this is the first documented case of the TGFBR1 gene mutation who suffered from abdominal aortic aneurysm complicated by descending thoracic aortic dissection. Her rapid death underscores the importance of timely intervention in TGFBR1 mutation-positive patients.
IVC collapsibility indices in assessment of volume overload in neonatal cardiac patients
Authors: Mahmoud Reham Osama , Moawad Khalid Mohamed Hasab Elnaby , Mansi Yasmeen Amr , Hashem Rania Hamdy 
Published: July 2024

Abstract
Background
Fluid overload is associated with increased morbidity and mortality in critically ill patients. An accurate assessment of fluid status in neonatal cardiac pediatric patients is required for assessment of fluid overload. Estimation of fluid status using different Doppler parameters may be helpful in determination of fluid status.

Purpose
To evaluate difference in fluid status in neonates with and without congenital heart diseases. To detect sensitivity of Doppler Ultrasound in early determination of fluid status. To compare between different parameters (IVC diameter, IVCCI, and IVC/AO ratio) between cardiac and healthy neonates.

Methods
Transabdominal Doppler parameters of 25 full-term newborns with congenital heart diseases and congestive heart failure were compared to 25 post-natal age and sex-matched normal healthy neonates serving as controls. Aortic as well as inspiratory and expiratory inferior vena cava diameters were measured. Subsequently, inferior vena cava collapsibility index (IVCCI) and inferior vena cava-to-aortic ratio (IVC/AO) were calculated.

Results
Fluid overload detected by increased IVC diameter (decreased IVCCI and increased IVC/AO ratio) was observed in the cardiac compared to the control group. There was positive correlation between the fluid volume and the IVC diameter and IVC/AO ratio and negative correlation with the IVC collapsibility indices.

Conclusions
Fluid overload with increased IVC diameter and lack of IVC collapsibility were observed in neonates with congenital heart diseases and congestive heart failure compared with those hemodynamically stable controls. We recommend the use of IVC diameter, IVCCI, and IVC/AO ratio as rapid, easy and sensitive parameters in assessing volume status.
Development of the Technical Assistance Engagement Scale: a modified Delphi study
Authors: Scott Victoria C. , Temple Jasmine , Jillani Zara 
Published: July 2024

Abstract
Background
Technical assistance (TA) is a tailored approach to capacity building that is commonly used to support implementation of evidence-based interventions. Despite its widespread applications, measurement tools for assessing critical components of TA are scant. In particular, the field lacks an expert-informed measure for examining relationship quality between TA providers and recipients. TA relationships are central to TA and significantly associated with program implementation outcomes. The current study seeks to address the gap in TA measurement tools by providing a scale for assessing TA relationships.

Methods
We utilized a modified Delphi approach involving two rounds of Delphi surveys and a panel discussion with TA experts to garner feedback and consensus on the domains and items that compose the TA Engagement Scale.

Results
TA experts represented various U.S. organizations and TA roles (e.g., provider, recipient, researcher) with 25 respondents in the first survey and 26 respondents in the second survey. The modified Delphi process resulted in a scale composed of six domains and 22 items relevant and important to TA relationships between providers and recipients.

Conclusion
The TA Engagement Scale is a formative evaluation tool intended to offer TA providers the ability to identify strengths and areas for growth in the provider-recipient relationship and to communicate about ongoing needs. As a standard measurement tool, it lends a step toward more systematic collection of TA data, the ability to generate a more coherent body of TA evidence, and enables comparisons of TA relationships across settings.
Development and evaluation of imiquimod-loaded nanoemulsion-based gel for the treatment of skin cancer
Authors: Jadhav Shital T. , Salunkhe Vijay R. , Bhinge Somnath D. , Honmane Sandip M. , Jadhav Aasha S. 
Published: July 2024

Abstract
Background
The human skin, as the body’s largest organ, is particularly sensitive to many chemical mutagens and carcinogens encountered in daily life. Skin cancer has become a notable global health concern, partly due to increased exposure to environmental pollutants and UV rays. Various treatments are available to treat skin cancer. Imiquimod is approved for the treatment of actinic keratosis and basal cell carcinoma. The present investigation aimed to develop nanoemulsion-based gel with imiquimod (2.5% w/w) and carbopol ultrez 10 NF using a modified method to enhance the solubility, permeation, and therapeutic effectiveness of imiquimod to treat skin cancer. Combinations of rose oil and oleic acid, with Tween 20/Propylene glycol as Smix, were used in the formulation. The formulation underwent evaluation for parameters such as % drug content, in vitro drug diffusion studies, viscosity, skin irritation, in vitro cytotoxicity assay (MTT assay) and the DMBA/ croton oil skin cancer in vivo model.

Results
The formulation showed a minimum globule size of 118 nm, a zeta potential– 56.26 mV, a PDI of 0.378 and a drug content of 99.77%. In vitro drug release exhibited 45.00% of imiquimod release within 8 h, while approximately 34.32% release was found from the commercial cream. The imiquimod-loaded nanoemulsion-based gel showed significant cytotoxicity (p < 0.001) against the A431 cell line compared to Imiquad cream. The IC50 value of the imiquimod-loaded nanoemulsion-based gel was noted to be 10.76 ± 2.54 µg/mL. In vivo results showed a significant reduction in tumor incidence (16.66%), tumor volume (140.26 ± 3.48 mm3), tumor burden (5.50 mm3) and tumor mass (0.66 ± 0.05 g) compared with the DMBA/croton oil carcinogen treatment control group. Histopathological finding showed the absence of keratinized pearls, epidermal hyperplasia, and acanthosis in the formulation treated group.

Conclusion
The results revealed that the nanoemulsion-based gel, with half the IMQ concentration of the commercial cream and incorporating Carbopol Ultrez 10NF, is a promising method for treating skin carcinogenesis. It potentially reduces dose-dependent side effects and demonstrating enhanced efficacy.

Graphical abstract
Omega-3 fatty acids: a comprehensive scientific review of their sources, functions and health benefits
Authors: Patted Pradnya G. , Masareddy Rajashree S. , Patil Archana S. , Kanabargi Ravikiran R. , Bhat Chetan T. 
Published: July 2024

Abstract
Background
In recent years, public awareness of healthy diets has significantly increased, leading to a rise in the consumption of nutritional supplements. Among these, omega-3 fatty acids have become particularly popular. n − 3 polyunsaturated fatty acids (PUFAs) are widely distributed in marine and terrestrial environments. The primary sources of marine n − 3 fatty acid supplements are oily fish, such as anchovies, sardines and mackerel. Recently, they have drawn considerable attention for their potential therapeutic benefits in treating a range of illnesses, including cancer, neurological disorders, cardiovascular diseases, immunological and reproductive diseases, respectively.

Main text
This study explores the many activities of n − 3 PUFAs, highlighting their importance in cellular processes that include signaling pathways, cell membrane integrity and structural maintenance. These fatty acids significantly regulate important physiological functions including the neurological system, blood pressure control, hematopoiesis, glucose metabolism and inflammatory responses. The latter highlights the wide therapeutic range of n − 3 PUFAs is especially notable considering the implications for controlling inflammatory disorders. Furthermore, the chemistry and dietary sources of omega-3 fatty acids are clarified in this review, which also sheds light on the complex molecular pathways that support the therapeutic efficacy of these fats and their bioavailability. The most recent information on the FDA's approval of omega-3 oils for use in formulation development highlights the compounds' adaptability and potential influence on the development of novel medications.

Conclusion
A thorough analysis of omega-3 polyunsaturated fatty acids reveals both their remarkable therapeutic potential against a variety of diseases and their essential place in a normal diet. This study adds to the increasing amount of data that supports the use of n − 3 PUFAs in preventative and therapeutic approaches that are meant to improve human health and well-being by clarifying their mechanisms of action and emphasizing their applicability in formulation and development.