bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phylogenetic Effect on Tree Radial Growth Depends on Drought and Tree Sizes
Authors: Linger Ewuketu , Lutz James A. , Cao Min , Zhang Wen‐Fu , Yang Xiao‐Fei , Deng Xiao‐Bao , Tang Yong , Hu Yue‐Hua 
Published: August 2024

AbstractTree radial growth is one of the most direct measures of tree performance and is also sensitive to climate. Growth performance is the consequence of the interplay between ecological and evolutionary processes. However, the effect of the evolutionary relatedness among species (i.e., phylogeny) on tree radial growth, especially under stressful conditions, remains largely unknown. Furthermore, there is still no ecological evidence for the influence of phylogeny on tree growth across different tree attributes (i.e., tree diameter variation and tree canopy height) and topographic habitat types. We used Blomberg's K to quantify the tree growth phylogenetic signal (TGPS) using two long‐term dendrometer data sets: one a continuous census of 225 tree species at 3‐month intervals in a tropical forest in southwest China from 2009 to 2017; the other, 12 tree species measured at 6‐month intervals in a temperate forest in Washington State, USA from 2013 to 2019. We found that TGPS values were higher in the temperate forest than in the tropical forest. Precipitation, tree diameter, canopy strata, and habitat types all influenced TGPS values. TGPS values were significantly (p < 0.05) and negatively related to precipitation in Xishuangbanna, and the three of four tree diameter classes in the temperate forest, respectively. Stressful growing conditions arose from either based on low precipitation or among large‐diameter trees competing with each other in the upper canopy led to phylogenetic conservatism in trees' radial growth performance. We conclude that phylogeny is pivotal to understanding the growth response differences among species and their responses to climate variability.
Closing Loopholes in Water Rights Systems to Save Water: The Colorado River Basin
Authors: Debaere P. , Li T. , Fox S. , Bennett K. , Block P. , Hietpas K. , Mekonnen M. , Quinn J. D. , Richter B. , Sharma S. , Singh S. 
Published: August 2024

AbstractAround the world, water rights systems govern the allocation of water to a multitude of users. Such systems primarily come into play during times of drought, when some users have to be shorted. Yet their management during times of excess can have implications for subsequent drought impacts. This is evident in the State of Colorado, where under “free river conditions” in which there is sufficient water to satisfy all water rights, anyone—including individuals lacking water rights—can divert as much as they want, unconstrained by the limit of their water right. Here, we estimate the amount of excess water used under such conditions within Division five of the Upper Colorado River Basin in the State of Colorado. Comparing the daily water withdrawals of diversion structures along the Colorado River and its tributaries with their (daily) water rights, we find that in 2017, 339 structures report days with excess withdrawals, amounting to 108 million cubic meters (87,577 acer feet). While such excess withdrawal is legal in Colorado, we argue that the free river condition is an antiquated rule that will make much needed reform of water allocation within the water‐stressed Colorado River Basin more difficult. We offer policy suggestions to address it.
Constraining Mean Landslide Occurrence Rates for Non‐Temporal Landslide Inventories Using High‐Resolution Elevation Data
Authors: Woodard J. B. , LaHusen S. R. , Mirus B. B. , Barnhart K. R. 
Published: August 2024

AbstractConstraining landslide occurrence rates can help to generate landslide hazard models that predict the spatial and temporal occurrence of landslides. However, most landslide inventories do not include any temporal data due to the difficulties of dating landslide deposits. Here we introduce a method for estimating the mean landslide occurrence rate of deep‐seated rotational and translational slides derived solely from high‐resolution (≤3 m) elevation data and globally available estimates of the diffusion coefficient for sediment flux. The method applies a linear diffusion model to the roughest landslide deposits until they reach a representative non‐landslide roughness distribution. This estimates the time for a landslide deposit to be unrecognizable in high‐resolution digital elevation data, which we term the mean lifetime of the landslide. Using the mean lifetime and number of landslides within an area of interest, we can estimate the mean occurrence rate of landslides over that domain. We validate this approach using a comprehensive temporal inventory of landslides in western Oregon created using age‐roughness curves that are calibrated with high‐resolution elevation data and radiocarbon data. We find good agreement between our diffusion method and the existing age‐roughness‐derived estimates, producing mean lifetimes of 4500 and 5200 years (4% difference), respectively. Hazard maps produced using the two methodologies generally agree, with the maximum differences in landslide probability reaching 0.1. Due to the relative abundance of high‐resolution elevation data compared with age‐dated landslides, our method could help constrain landslide occurrence rates in areas previously considered unfeasible.
Hyperspectral Imaging Predicts Differences in Carbon and Nitrogen Status Among Representative Biocrust Functional Groups of the Colorado Plateau
Authors: Yan Dong , Reed Sasha C. , Rutherford William A. , Javadian Mostafa , Reibold Robin H. , Villarreal Miguel , Poulter Benjamin , Song Shujun , Smith William K. 
Published: August 2024

AbstractBiological soil crusts (biocrusts) are widespread soil photosynthetic communities covering about 12% of Earth's land surface, and play crucial roles in terrestrial carbon (C) and nitrogen (N) cycles, yet scalable quantifications of biocrusts and their biogeochemical contributions are notably lacking. While remote sensing has enormous potential to assess, scale, and contextualize biocrusts and their functions, the applicability of hyperspectral data in predicting C‐ and N‐related biocrust traits remains largely unexplored. We address this issue by evaluating the potential of in situ hyperspectral data to predict C and N across a range of biocrust species and different environmental conditions. We found that in situ hyperspectral reflectance measurements can be used to predict biocrust tissue C/N ratios and N concentrations with relatively high accuracy but to a lesser extent for potential biocrust N2 fixation rates. Critical wavelength domains included the visible region of the spectrum from roughly 490–600 nm, which most effectively captured variations in biocrust tissue C, and the shortwave infrared region from 1,150 to 1,350 nm and 1,550–1,650 nm, which most effectively captured biocrust tissue N and N2 fixation potential. Finally, we provide evidence that multi‐ and hyperspectral missions with targeted band placement, such as the proposed 26‐band Landsat Next, could be effective in predicting biocrust traits. This work provides a critical step in understanding how to apply data from new and upcoming satellite missions to the monitoring of biocrusts.
Defining child health in the 21st century
Authors: Stein Ruth E. K. 
Published: August 2024

Abstract
The concept of child health has evolved over many decades and has gone from defining health as the absence of disease and disability to a much more sophisticated understanding of the ways in which a confluence of many factors leads to a healthy childhood and to producing the infrastructure for a healthy lifetime. We review the evolution of these ideas and endorse the definition featured in Children’s Health, the Nation’s Wealth, which states that child health is: “… the extent to which individual children or groups of children are able or enabled to: (a) develop and realize their potential, (b) satisfy their needs, and (c) develop the capacities that allow them to interact successfully with their biological, physical, and social environments.”

Impact

The definition of child health and the model presented form a framework for conducting and interpreting research in child health and understanding the ways in which influences affect child health.

They also demonstrate how child health is the foundation for life-long health.

Child health is dynamic and is always changing.

There are many influences affecting child health at any given time.

Because each child’s health is different, they may react in distinctive ways to a new health challenge.
LPA suppresses HLA-DR expression in human melanoma cells: a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10
Authors: Major Enikő , Lin Kuan-Hung , Lee Sue Chin , Káldi Krisztina , Győrffy Balázs , Tigyi Gábor J. , Benyó Zoltán 
Published: August 2024

AbstractWhile immune checkpoint inhibitors (ICIs) are promising in the treatment of metastatic melanoma, about half of patients do not respond well to them. Low levels of human leukocyte antigen-DR (HLA-DR) in tumors have been shown to negatively influence prognosis and response to ICIs. Lysophosphatidic acid (LPA) is produced in large amounts by melanoma and is abundantly present in the tumor microenvironment. LPA induces the release of various cytokines and chemokines from tumor cells, which affect cancer development, metastasis, and tumor immunity. In the present study, we investigated the role of LPA-induced IL-10 release in regulating HLA-DR expression and the underlying mechanisms in human melanoma cells. We showed that LPA (0.001–10 μM) dose-dependently increased DR6 transcript levels through activating LPAR1 in HEK293T cells. Knockdown of NF-κB1 abrogated the LPA-increased DR6 expression without affecting basal DR6 expression in both A2058 and A375 melanoma cell lines. LPA (10 µM) significantly increased IL-10 transcripts in A2058 and A375 melanoma cells, the effect was abolished by pharmacological inhibition of LPAR1 or knockdown of DR6. We found a statistically significant correlation between the expression of LPAR1, DR6 and IL-10 in human melanoma tissue and an association between increased expression of LPAR1 and reduced effectiveness of ICI therapy. We demonstrated that LPA (10 µM) markedly suppressed HLA-DR expression in both A375 and A2058 melanoma cells via activating the LPAR1-DR6-IL-10 pathway. These data suggest that the LPAR1-DR6-IL-10 autocrine loop could constitute a novel mechanism used by tumor cells to evade immunosurveillance by decreasing HLA-DR expression.
BEAM or cyclophosphamide in autologous haematopoietic stem cell transplantation for relapsing-remitting multiple sclerosis
Authors: Silfverberg Thomas , Zjukovskaja Christina , Noui Yassine , Carlson Kristina ,   AutoMS-Swe Investigators, Nahimi Adjmal , Erik Ahlstrand , Honar Cherif , Arta Dreimane , Sigrun Einarsdottir , Jan Fagius , Hans Hägglund , Ellen Iacobaeus , Niclas Lange , Stig Lenhoff , Per Ljungman , Jan Lycke , Johan Mellergård , Fredrik Piehl , Anders Svenningsson , Andreas Tolf , Burman Joachim 
Published: August 2024

AbstractThe most widely used conditioning regimens in autologous haematopoietic stem cell transplantation (ASCT) for multiple sclerosis (MS) are BEAM with anti-thymocyte globulin (ATG) and high-dose cyclophosphamide with ATG (Cy/ATG). In this retrospective study, we compare efficacy and safety of these regimens when used for relapsing-remitting MS. We assessed 231 patients treated in Sweden before January 1, 2020. The final cohort comprised 33 patients treated with BEAM/ATG and 141 with Cy/ATG. Prospectively collected data from the Swedish MS registry were used for efficacy, and electronic health records for procedure-related safety. The Kaplan–Meier estimate of ‘no evidence of disease activity’ (NEDA) at 5 years was 81% (CI 68–96%) with BEAM/ATG and 71% (CI 63–80%) with Cy/ATG, p = 0.29. Severe adverse events were more common with BEAM/ATG, mean 3.1 vs 1.4 per patient, p = <0.001. Febrile neutropaenia occurred in 88% of BEAM/ATG patients and 68% of Cy/ATG patients, p = 0.023. Average hospitalisation was 3.0 days longer in BEAM/ATG patients from day of stem-cell infusion, p < 0.001. While both regimens showed similar efficacy, BEAM/ATG was associated with more severe adverse events and prolonged hospitalisation. In the absence of randomised controlled trials, Cy/ATG may be preferable for ASCT in patients with relapsing-remitting MS due to its favourable safety profile.
Superoxide dismutase 1 mediates adaptation to the tumor microenvironment of glioma cells via mammalian target of rapamycin complex 1
Authors: König Sven , Strassheimer Florian , Brandner Nadja I. , Schröder Jan-Hendrik , Urban Hans , Harwart Leander F. , Hehlgans Stephanie , Steinbach Joachim P. , Ronellenfitsch Michael W. , Luger Anna-Luisa 
Published: August 2024

AbstractIn glioblastoma (GB) cells oxidative stress is induced by both, conditions of the tumor microenvironment as well as by therapeutic interventions. Upregulation of superoxide dismutase 1 (SOD1), a key enzyme for oxidative defense and downstream target of mammalian target of rapamycin complex 1 (mTORC1) is a candidate mechanism to sustain survival and proliferation of tumor cells. SOD1 was inhibited by shRNA mediated gene suppression, CRISPR/Cas9 knockout and pharmacological inhibition in human (primary) GB cells. SOD1 activity was determined by SOD1/2 activity assay. ROS levels, cell death and the NADPH/NADP-ratio were measured under normal and starvation conditions. To study the mTORC1-SOD1 axis, mTORC1 activated TSC2 knockdown cells (TSC2sh) were analyzed. Genetic and pharmacological inhibition of SOD1 correlated with decreased SOD1 activity, increased ROS and enhanced the sensitivity of glioma cells towards starvation- and hypoxia-induced cell death. This was accompanied by a decreased NADPH/NADP-ratio. Furthermore, combination therapy of SOD1 and mTORC1 inhibition partially rescued the protective effect of mTORC1 inhibitor monotherapy. SOD1 mediates adaptation of GB cells to stress conditions in the tumor microenvironment in a mTORC1-dependent manner. Moreover, SOD1 activation contributes to the cell death resistance conferred by mTORC1 inhibitors under hypoxic conditions.
High aggressiveness of papillary thyroid cancer: from clinical evidence to regulatory cellular networks
Authors: Zhang Junsi , Xu Sunwang 
Published: August 2024

AbstractThe global incidence of thyroid cancer has increased over recent decades. Papillary thyroid cancer (PTC) is the most common type of thyroid cancer and accounts for nearly 90% of all cases. Typically, PTC has a good prognosis. However, some PTC variants exhibit more aggressive behaviour, which significantly increases the risk of postoperative recurrence. Over the past decade, the high metastatic potential of PTC has drawn the attention of many researchers and these studies have provided useful molecular markers for improved diagnosis, risk stratification and clinical approaches. The aim of this review is to discuss the progress in epidemiology, metastatic features, risk factors and molecular mechanisms associated with PTC aggressiveness. We present a detailed picture showing that epithelial-to-mesenchymal transition, cancer metabolic reprogramming, alterations in important signalling pathways, epigenetic aberrations and the tumour microenvironment are crucial drivers of PTC metastasis. Further research is needed to more fully elucidate the pathogenesis and biological behaviour underlying the aggressiveness of PTC.
Larger colony sizes favoured the evolution of more worker castes in ants
Authors: Bell-Roberts Louis , Turner Juliet F. R. , Werner Gijsbert D. A. , Downing Philip A. , Ross Laura , West Stuart A. 
Published: August 2024

AbstractThe size–complexity hypothesis is a leading explanation for the evolution of complex life on earth. It predicts that in lineages that have undergone a major transition in organismality, larger numbers of lower-level subunits select for increased division of labour. Current data from multicellular organisms and social insects support a positive correlation between the number of cells and number of cell types and between colony size and the number of castes. However, the implication of these results is unclear, because colony size and number of cells are correlated with other variables which may also influence selection for division of labour, and causality could be in either direction. Here, to resolve this problem, we tested multiple causal hypotheses using data from 794 ant species. We found that larger colony sizes favoured the evolution of increased division of labour, resulting in more worker castes and greater variation in worker size. By contrast, our results did not provide consistent support for alternative hypotheses regarding either queen mating frequency or number of queens per colony explaining variation in division of labour. Overall, our results provide strong support for the size–complexity hypothesis.
Birth of protein folds and functions in the virome
Authors: Nomburg Jason , Doherty Erin E. , Price Nathan , Bellieny-Rabelo Daniel , Zhu Yong K. , Doudna Jennifer A. 
Published: August 2024

AbstractThe rapid evolution of viruses generates proteins that are essential for infectivity and replication but with unknown functions, due to extreme sequence divergence1. Here, using a database of 67,715 newly predicted protein structures from 4,463 eukaryotic viral species, we found that 62% of viral proteins are structurally distinct and lack homologues in the AlphaFold database2,3. Among the remaining 38% of viral proteins, many have non-viral structural analogues that revealed surprising similarities between human pathogens and their eukaryotic hosts. Structural comparisons suggested putative functions for up to 25% of unannotated viral proteins, including those with roles in the evasion of innate immunity. In particular, RNA ligase T-like phosphodiesterases were found to resemble phage-encoded proteins that hydrolyse the host immune-activating cyclic dinucleotides 3′,3′- and 2′,3′-cyclic GMP-AMP (cGAMP). Experimental analysis showed that RNA ligase T homologues encoded by avian poxviruses similarly hydrolyse cGAMP, showing that RNA ligase T-mediated targeting of cGAMP is an evolutionarily conserved mechanism of immune evasion that is present in both bacteriophage and eukaryotic viruses. Together, the viral protein structural database and analyses presented here afford new opportunities to identify mechanisms of virus–host interactions that are common across the virome.
Sorption behavior of strontium and europium ions from aqueous solutions using fabricated inorganic sorbent based on talc
Authors: Abass M. R. , Abou-Lilah R. A. , Hussein L. M. S. 
Published: August 2024

AbstractSorption of Sr(II) and Eu(III) from aqueous solutions was studied using tin molybdate talc sorbent synthesized by the precipitation technique. The synthesized sorbent was characterized using different analytical tools, such as; FT-IR, SEM, XRD, XRF, TGA, and DTA. The sorption studies applied to Sr(II) and Eu(III) include the effects of shaking time, pH, concentrations, and saturation capacity. The sorption of Sr(II) and Eu(III) depends on pH, reaction kinetics obey the pseudo-2nd-order model, and the Langmuir model is better suited for the sorption isotherm. The thermodynamic parameters reflect an endothermic and spontaneous sorption process. Desorption studies showed that 0.1 M HCl was the best desorbing agent for the complete recovery of Sr(II) (96.8%) and Eu(III) (92.9%). Finally, the obtained data illustrates that the synthesized sorbent can be applied and used as an efficient sorbent for the sorption of Sr(II) and Eu(III) from aqueous solutions and can be used as a promising sorbent to remove Sr(II) and Eu(III).
Balanced parametric body prior for implicit clothed human reconstruction from a monocular RGB
Authors: Xue Rong , Li Jiefeng , Lu Cewu 
Published: August 2024

AbstractThe authors study the problem of reconstructing detailed 3D human surfaces in various poses and clothing from images. The parametric human body allows accurate 3D clothed human reconstruction. However, the offset of large and loose clothing from the inferred parametric body mesh confines the generalisation of the existing parametric body‐based methods. A distinctive method that simultaneously generalises well to unseen poses and unseen clothing is proposed. The authors first discover the unbalanced nature of existing implicit function‐based methods. To address this issue, the authors propose to synthesise the balanced training samples with a new dependency coefficient in training. The dependency coefficient can tell the network whether the prior from the parametric body model is reliable. The authors then design a novel positional embedding‐based attenuation strategy to incorporate the dependency coefficient into the implicit function (IF) network. Comprehensive experiments are conducted on the CAPE dataset to study the effectiveness of the authors’ approach. The proposed method significantly surpasses state‐of‐the‐art approaches and generalises well on unseen poses and clothing. As an illustrative example, the proposed method improves the Chamfer Distance Error and Normal Error by 38.2% and 57.6%.
Knowledge‐aided cooperative jamming cancellation architecture in physical layer security
Authors: Bo Juntian , Wang Hengfeng , Su Binbin , Zhang Jiahao , Meng Jin 
Published: August 2024

AbstractThis article proposes a cooperative jamming (CJ) architecture based on the coded signal of interest (SOI). The CJ is superimposed on the coded SOI directly at the transmitter, and the authorized user reconstructs the received signal and cancels the CJ based on the prior knowledge of the coding information, then different radiation patterns after cancellation are created for SOI and CJ, which effectively cancels CJ while retaining SOI. Eavesdropper, however, is unaware of the coding information and will cause significant loss to the SOI while cancelling the CJ, therefore unable to achieve eavesdropping on communication signals. Numerical results verify the feasibility of the proposed method.
Quasi‐Helmholtz projector including multibranch Rao‐Wilton‐Glisson basis functions for multiscale objects at low frequency
Authors: Wang Yu , Dang Xiaojie , Zhu Ming‐da 
Published: August 2024

AbstractIn this letter, a Quasi‐Helmholtz Projector method including multibranch Rao‐Wilton‐Glisson (MB‐RWG) basis function to calculate the scattering problem of multiscale targets at low frequencies is proposed. The loop basis function and the star basis function including MB‐RWG basis function are constructed, and the loop basis function and the star basis function including MB‐RWG basis function are used to construct the Quasi‐Helmholtz Projector. The proposed method is coined MB‐Quasi‐Helmholtz Projector (MB‐QHP) method. The MB‐QHP method can effectively solve the low frequency breakdown (LFB) problem in electric field integral equation (EFIE). Compared with the MB‐loop‐star method, the condition number is lower, the convergence is faster, and the search for global loop is avoided. Meanwhile, due to the existence of the MB‐RWG basis function, the proposed method can divide the calculation region into several regions with different mesh sizes. Numerical example shows the advantages of the proposed method.