bluuebunny/crossref_metadata_2025_split huggingface dataset:
Danish translation and validation of the International Skin Tear Advisory Panel Skin Tear Classification System
Authors: Skiveren J. , Bermark S. , LeBlanc K. , Baranoski S. 
Published: August 2015

Objective: The aim of this study was to translate, validate and establish reliability of the International Skin Tear Classification System in Danish. Method: Phase 1 of the project involved the translation of the International Skin Tear Advisory Panel (ISTAP) Skin Tear Classification System into Danish, using the forward–back translation method described by the principles of good practice for the translation process for patient-reported outcomes. In Phase 2, the Danish group sought to replicate the ISTAP validation study and validate the classification system with registered nurses (RN) and social and health-care assistants (non-RN) from both primary health care and a Danish university hospital in Copenhagen. Thirty photographs, with equal representation of the three types of skin tears, were selected to test validity. The photographs chosen were those originally used for internal and external validation by the ISTAP group. The subjects were approached in their place of work and invited to participate in the study and to attend an educational session related to skin tears. Results: The Danish translation of the ISTAP classification system was tested on 270 non-wound specialists. The ISTAP classification system was validated by 241 RNs, and 29 non-RN. The results indicated a moderate level of agreement on classification of skin tears by type (Fleiss’ Kappa=0.460). A moderate level of agreement was demonstrated for both the RN group and the non-RN group (Fleiss’ Kappa=0.464 and 0.443, respectively). Conclusion: The ISTAP Skin Tear Classification System was developed with the goal of establishing a global language for describing and documenting skin tears and to raise the health-care community's awareness of skin tears. The Danish translation of the ISTAP classification system supports the earlier ISTAP study and further validates the classification system. The Danish translation of the classification system is vital to the promotion of skin tears in both research and the clinical settings in Denmark.
Augmenting Predictive Modeling Tools with Clinical Insights for Care Coordination
Program Design and Implementation
Authors: Johnson Tracy L. , Brewer Daniel , Estacio Raymond , Vlasimsky Tara , Durfee Michael J. , Thompson Kathy R. , Everhart Rachel M. , Rinehart Deborath J. , Batal Holly 
Published: August 2015

Context: The Center for Medicare and Medicaid Innovation (CMMI) awarded Denver
Health's (DH) integrated, safety net health care system $19.8 million to implement a
“population health” approach into the delivery of primary care. This major practice
transformation builds on the Patient Centered Medical Home (PCMH) and Wagner’s Chronic
Care Model (CCM) to achieve the “Triple Aim”: improved health for populations, care to
individuals, and lower per capita costs.Case description: This paper presents a case
study of how DH integrated published predictive models and front-line clinical judgment
to implement a clinically actionable, risk stratification of patients. This population
segmentation approach was used to deploy enhanced care team staff resources and to
tailor care-management services to patient need, especially for patients at high risk of
avoidable hospitalization. Developing, implementing, and gaining clinical acceptance of
the Health Information Technology (HIT) solution for patient risk stratification was a
major grant objective.Findings: In addition to describing the Information Technology
(IT) solution itself, we focus on the leadership and organizational processes that
facilitated its multidisciplinary development and ongoing iterative refinement,
including the following: team composition, target population definition, algorithm rule
development, performance assessment, and clinical-workflow optimization. We provide
examples of how dynamic business intelligence tools facilitated clinical accessibility
for program design decisions by enabling real-time data views from a population
perspective down to patient-specific variables.Conclusions: We conclude that population
segmentation approaches that integrate clinical perspectives with predictive modeling
results can better identify high opportunity patients amenable to medical home-based,
enhanced care team interventions.
Mietpreise deutscher Lebensmitteldiscounter
Authors: Segerer Matthias , Klein Kurt 
Published: August 2015

Zusammenfassung
Der vorliegende Beitrag liefert eine wissenschaftlich fundierte Analyse der Bestimmungsgründe des Mietpreises von LM-Discountern. Bislang sind Mietpreise für Handelsimmobilien hauptsächlich auf standortspezifische Merkmale mit Bezug zum Umsatz zurückgeführt worden. Diese absatzwirtschaftliche Perspektive bezieht insbesondere Angebots- und Nachfragevariablen, in selteneren Fällen auch Mietvertragsvariablen in ihre Erklärung mit ein, wobei bereits die Zuordnung der Verkaufsfläche als Angebotsmerkmal aus Immobilienperspektive strittig ist. Deshalb wird hier ein Zwei-Ebenen-Ansatz verfolgt, dessen Ziel es ist, zum einen den für die Praxis geeigneten Ansatz zur Bestimmung des Mietpreises zu finden. Zum anderen sollen aber auch die für einen Investor wichtigen Dimensionen der Immobilienwirtschaft beispielhaft an dieser für eine klar definierte Handelsbetriebsform erstellten Immobilie herausgearbeitet und in ihrem Erklärungsgehalt für den Mietpreis aufgezeigt werden.
Konzeptionell gelingt dies auf der ersten Ebene mit einer konsequenten Einordnung der Variablen zu übergeordneten Kategorien (Angebot, Nachfrage, Immobilienobjekt, Mieter). Mit Hilfe einer schrittweisen Regression werden die wichtigsten Einflussgrößen herausgefiltert und dienen zur praktischen Bestimmung der Miete. Die zweite Ebene gelangt über den Einsatz der strukturaufdeckenden Methode der Faktorenanalyse zu einer Neuzuordnung der Variablen zu Dimensionen mit Immobilienorientierung (z. Bsp. Standortzukunft, Baualter, Vertragsdauer), deren Einfluss auf den Mietpreis über eine Regression mit Einschluss quantifiziert wird. Damit wird auch ein konzeptioneller Beitrag zum Verständnis der immobilienwirtschaftlichen Bedeutung der Miete für Discountimmobilien und indirekt für die Risikominimierung einer Investitionsentscheidung geleistet.
Existence and global asymptotic behavior of positive solutions for combined second-order differential equations on the half-line
Authors: Bachar Imed , Mâagli Habib 
Published: August 2015

AbstractWe are concerned with the existence, uniqueness and global asymptotic behavior of positive continuous solutions to the second-order boundary value problem1A⁢(A⁢u′)′+a1⁢(t)⁢uσ1+a2⁢(t)⁢uσ2=0,t∈(0,∞),$\frac{1}{A}(Au^{\prime})^{\prime}+a_{1}(t)u^{\sigma_{1}}+a_{2}(t)u^{\sigma_{2}% }=0,\quad t\in(0,\infty),$subject to the boundary conditionslimt→0+⁡u⁢(t)=0${\lim_{t\rightarrow 0^{+}}u(t)=0}$,limt→∞⁡u⁢(t)/ρ⁢(t)=0${\lim_{t\rightarrow\infty}{u(t)}/{\rho(t)}=0}$, whereσ1,σ2<1${\sigma_{1},\sigma_{2}<1}$andAis a continuous function on[0,∞)${[0,\infty)}$which is positive and differentiable on(0,∞)${(0,\infty)}$such that∫011/A⁢(t)⁢𝑑t<∞${\int_{0}^{1}{1}/{A(t)}\,dt<\infty}$and∫0∞1/A⁢(t)⁢𝑑t=∞${\int_{0}^{\infty}{1}/{A(t)}\,dt=\infty}$. Here,ρ⁢(t)=∫0t1/A⁢(s)⁢𝑑s${\rho(t)=\int_{0}^{t}{1}/{A(s)}\,ds}$fort>0${t>0}$anda1,a2${a_{1},a_{2}}$are nonnegative continuous functions on(0,∞)${(0,\infty)}$that may be singular att=0${t=0}$and satisfying some appropriate assumptions related to the Karamata regular variation theory. Our approach is based on the sub-supersolution method.
An Algorithm for the Numerical Solution of Two-Sided Space-Fractional Partial Differential Equations
Authors: Ford Neville J. , Pal Kamal , Yan Yubin 
Published: August 2015

Abstract
We introduce an algorithm for solving two-sided space-fractional partial differential equations. The space-fractional derivatives we consider here are left-handed and right-handed Riemann–Liouville fractional derivatives which are expressed by using Hadamard finite-part integrals. We approximate the Hadamard finite-part integrals by using piecewise quadratic interpolation polynomials and obtain a numerical approximation of the space-fractional derivative with convergence order

O
(
Δ

x

3
-
α

)

${O(\Delta x^{3- \alpha })}$

,

1
<
α
<
2

${1&lt;\alpha &lt;2}$

. A shifted implicit finite difference method is applied for solving the two-sided space-fractional partial differential equation and we prove that the order of convergence of the finite difference method is

O
(
Δ
t
+
Δ

x

min
(
3
-
α
,
β
)

)

${O (\Delta t + \Delta x^{\min (3- \alpha , \beta )})}$

,

1
<
α
<
2

${1&lt; \alpha &lt;2}$

,

β
>
0

${\beta &gt;0}$

, where

Δ
t
,
Δ
x

${\Delta t,\Delta x}$

denote the time and space stepsizes, respectively. Numerical examples where the solutions have varying degrees of smoothness are presented and compared with the exact analytical solution to compare the practical performance of the method with the theoretical order of convergence.
Co3O4 and CDots nanocrystals on g-C3N4 as a synergetic catalyst for oxygen reduction reaction
Authors: Wang Huihua , Yang Yanmei , Qu Tianpeng , Kang Zhenhui , Wang Deyong 
Published: August 2015

AbstractDue to the demand of an efficient, inexpensive and scalable synthesis of an oxygen reduction reaction (ORR) catalyst for practical application in fuel cells, we demonstrate a facile strategy to fabricate the flexible Co
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
Authors: Becker Andreas , Eichentopf Rico , Sedlmeier Reinhard , Waniek Alexander , Cynis Holger , Koch Birgit , Stephan Anett , Bäuscher Christoph , Kohlmann Stephanie , Hoffmann Torsten , Kehlen Astrid , Berg Sabine , Freyse Ernst-Joachim , Osmand Alexander , Plank Anne-Christine , Roßner Steffen , von Hörsten Stephan , Graubner Sigrid , Demuth Hans-Ulrich , Schilling Stephan 
Published: August 2015

Abstract
Secretory peptides and proteins are frequently modified by pyroglutamic acid (pE, pGlu) at their N-terminus. This modification is catalyzed by the glutaminyl cyclases QC and isoQC. Here, we decipher the roles of the isoenzymes by characterization of IsoQC-/- mice. These mice show a significant reduction of glutaminyl cyclase activity in brain and peripheral tissue, suggesting ubiquitous expression of the isoQC enzyme. An assay of substrate conversion in vivo reveals impaired generation of the pGlu-modified C-C chemokine ligand 2 (CCL2, MCP-1) in isoQC-/- mice. The pGlu-formation was also impaired in primary neurons, which express significant levels of QC. Interestingly, however, the formation of the neuropeptide hormone thyrotropin-releasing hormone (TRH), assessed by immunohistochemistry and hormonal analysis of hypothalamic-pituitary-thyroid axis, was not affected in isoQC-/-, which contrasts to QC-/-. Thus, the results reveal differential functions of isoQC and QC in the formation of the pGlu-peptides CCL2 and TRH. Substrates requiring extensive prohormone processing in secretory granules, such as TRH, are primarily converted by QC. In contrast, protein substrates such as CCL2 appear to be primarily converted by isoQC. The results provide a new example, how subtle differences in subcellular localization of enzymes and substrate precursor maturation might influence pGlu-product formation.
Constitutive Equation for 3104 Alloy at High Temperatures in Consideration of Strain
Authors: Zhen Fuqiang , Sun Jianlin , Li Jian 
Published: August 2015

Abstract
The flow behavior of 3104 aluminum alloy was investigated at temperatures ranging from 250°C to 500°C, and strain rates from 0.01 to 10 s−1 by isothermal compression tests. The true stress–strain curves were obtained from the measured load–stroke data and then modified by friction and temperature correction. The effects of temperature and strain rate on hot deformation behavior were represented by Zener–Hollomon parameter including Arrhenius term. Additionally, the influence of strain was incorporated considering the effect of strain on material constants. The derived constitution equation was applied to the finite element analysis of hot compression. The results show that the simulated force is consistent with the measured one. Consequently, the developed constitution equation is valid and feasible for numerical simulation in hot deformation process of 3104 alloy.
Intercultural communication and the transnational: managing impressions at work
Authors: Yates Lynda 
Published: August 2015

AbstractWhether in pursuit of a safer place to live, economic advancement or simply from a desire to travel, increasing numbers of professionals find themselves working outside familiar cultural settings and using a language in which they did not train. As a country of migration, Australia is home to many such transnationals. Despite high levels of proficiency in English, however, many find that communication at work can be something of a challenge, and that different perspectives on professional roles and identities as well as differences in pragmalinguistic and sociopragmatic assumptions can become invisible barriers to success and progression. In this article I will draw on recent research into the demands of two different professions, childcare and medicine, to consider some of the issues faced by transnationals seeking to master not only the language but also the professional and community cultures underlying talk at work. I argue that language instruction programs designed to prepare new arrivals to enter the workforce should include explicit attention to cultural values based on empirical evidence in order to increase understanding of both how and why people talk the way they do in different working environments.
Speaking like “us”: self- and other-categorization as Norwegian speakers in student interactions
Authors: Sickinghe Anne-Valérie 
Published: August 2015

AbstractThis article investigates the manner in which students in Norwegian upper secondary schools negotiate “legitimate speaker” category membership in spoken interactions. It is concerned with adolescents’ linguistic identity as Norwegian speakers, and the language ideologies that inform categorization practices. Three collaborative features are distinguished to identify membership categorization practices: the pragmatic notion of scales of time and place; pronouns, in particular the personal pronouns “we”, “us”, and “they”; and the socio-epistemic notion of object-side assessments. The article asks whether the students’ categories correspond to those of education policy and research, and finds that students operate with more complex membership categorizations than the binary Norwegian/non-Norwegian division found in applied linguistic research and policy documents. It also finds that status as “expert” speaker of Norwegian is negotiable in student interactions, where social factors such as interpersonal relations, perceived social differences and performance of category-bound activities are as important as linguistic factors. The article shows how both non-native and native speakers of Norwegian can discursively construct themselves and others as more or less expert speakers of the language. As such, it contributes with insights on how institutionally defined linguistic markets, linguistic capital and legitimate speakers can be contested at the local level of student interactions.
A compact plasmonic MOS-based 2×2 electro-optic switch
Authors: Ye Chenran , Liu Ke , Soref Richard A. , Sorger Volker J. 
Published: August 2015

Abstract We report on a three-waveguide electro-optic switch for compact photonic
integrated circuits and data routing applications. The device features a
plasmonic metal-oxide-semiconductor (MOS) mode for enhanced
light-matter-interactions. The switching mechanism originates from a
capacitor-like design where the refractive index of the active medium,
indium-tin-oxide, is altered via shifting the plasma frequency due to carrier
accumulation inside the waveguide-based MOS structure. This light manipulation
mechanism controls the transmission direction of transverse magnetic polarized
light into either a CROSS or BAR waveguide port. The extinction ratio of 18 (7)
dB for the CROSS (BAR) state, respectively, is achieved via a gating voltage
bias. The ultrafast broadband fJ/bit device allows for seamless integration with
silicon-on-insulator platforms for low-cost manufacturing.
Polycrystalline and single phase FeS2 films grown by chemical bath deposition
Authors: Aluri Vedavathi , Ramakrishna Reddy Kotte Thulasi , Reddy Yerpedu Munikrishna 
Published: August 2015

Abstract
Recently, iron disulphide (FeS2) has been considered as a potential solar absorber material due to several factors. These include more abundance and less toxicity of the elements involved, suitable energy band gap (0.95 eV) with high optical absorption coefficient and sufficiently long minority carrier diffusion length to produce short circuit currents >30 mA. Thin films of FeS2 have been grown by a variety of physical as well as chemical methods. In this work, a simple wet chemical process, chemical bath deposition, was used to synthesise FeS2 films using iron sulphate and thiourea as precursors. Ammonia was used in combination with EDTA as a novel complexing agent to form the layers for the first time. The films were deposited using different bath temperatures (Tb) that vary in the range 50°C–70°C, keeping the other deposition parameters constant. The chemical and physical properties of the films were investigated using appropriate techniques.
An Integrated Optimization Design Method Based on Surrogate Modeling Applied to Diverging Duct Design
Authors: Hanan Lu , Qiushi Li , Shaobin Li 
Published: August 2015

AbstractThis paper presents an integrated optimization design method in which uniform design, response surface methodology and genetic algorithm are used in combination. In detail, uniform design is used to select the experimental sampling points in the experimental domain and the system performance is evaluated by means of computational fluid dynamics to construct a database. After that, response surface methodology is employed to generate a surrogate mathematical model relating the optimization objective and the design variables. Subsequently, genetic algorithm is adopted and applied to the surrogate model to acquire the optimal solution in the case of satisfying some constraints. The method has been applied to the optimization design of an axisymmetric diverging duct, dealing with three design variables including one qualitative variable and two quantitative variables. The method of modeling and optimization design performs well in improving the duct aerodynamic performance and can be also applied to wider fields of mechanical design and seen as a useful tool for engineering designers, by reducing the design time and computation consumption.
Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability
Authors: Shimada Mikio , Dumitrache Lavinia C , Russell Helen R , McKinnon Peter J 
Published: August 2015

AbstractPolynucleotide kinase–phosphatase (PNKP) is a DNA repair factor possessing both 5′‐kinase and 3′‐phosphatase activities to modify ends of a DNA break prior to ligation. Recently, decreased PNKP levels were identified as the cause of severe neuropathology present in the human microcephaly with seizures (MCSZ) syndrome. Utilizing novel murine Pnkp alleles that attenuate expression and a T424GfsX48 frame‐shift allele identified in MCSZ individuals, we determined how PNKP inactivation impacts neurogenesis. Mice with PNKP inactivation in neural progenitors manifest neurodevelopmental abnormalities and postnatal death. This severe phenotype involved defective base excision repair and non‐homologous end‐joining, pathways required for repair of both DNA single‐ and double‐strand breaks. Although mice homozygous for the T424GfsX48 allele were lethal embryonically, attenuated PNKP levels (akin to MCSZ) showed general neurodevelopmental defects, including microcephaly, indicating a critical developmental PNKP threshold. Directed postnatal neural inactivation of PNKP affected specific subpopulations including oligodendrocytes, indicating a broad requirement for genome maintenance, both during and after neurogenesis. These data illuminate the basis for selective neural vulnerability in DNA repair deficiency disease.
Human 3β-hydroxysteroid dehydrogenase deficiency seems to affect fertility but may not harbor a tumor risk: lesson from an experiment of nature
Authors: Burckhardt Marie-Anne , Udhane Sameer S , Marti Nesa , Schnyder Isabelle , Tapia Coya , Nielsen John E , Mullis Primus E , Rajpert-De Meyts Ewa , Flück Christa E 
Published: August 2015

Context3β-hydroxysteroid dehydrogenase deficiency (3βHSD) is a rare disorder of sexual development and steroidogenesis. There are two isozymes of 3βHSD,HSD3B1andHSD3B2. Human mutations are known for theHSD3B2gene which is expressed in the gonads and the adrenals. Little is known about testis histology, fertility and malignancy risk.ObjectiveTo describe the molecular genetics, the steroid biochemistry, the (immuno-)histochemistry and the clinical implications of a loss-of-functionHSD3B2mutation.MethodsBiochemical, genetic and immunohistochemical investigations on human biomaterials.ResultsA 46,XY boy presented at birth with severe undervirilization of the external genitalia. Steroid profiling showed low steroid production for mineralocorticoids, glucocorticoids and sex steroids with typical precursor metabolites for HSD3B2 deficiency. The genetic analysis of theHSD3B2gene revealed a homozygous c.687del27 deletion. At pubertal age, he showed some virilization of the external genitalia and some sex steroid metabolites appeared likely through conversion of precursors secreted by the testis and converted by unaffectedHSD3B1in peripheral tissues. However, he also developed enlarged breasts through production of estrogens in the periphery. Testis histology in late puberty revealed primarily a Sertoli-cell-only pattern and only few tubules with arrested spermatogenesis, presence of few Leydig cells in stroma, but no neoplastic changes.ConclusionsThe testis with HSD3B2 deficiency due to the c.687del27 deletion does not express the defective protein. This patient is unlikely to be fertile and his risk for gonadal malignancy is low. Further studies are needed to obtain firm knowledge on malignancy risk for gonads harboring defects of androgen biosynthesis.
Celularidade do sangue de cordão umbilical de gestantes hipertensas: estudo caso-controle
Authors: Marques Dulcinéa Luzia de Oliveira Lima , Oliveira Beatriz Guitton Renaud Baptista , Izu Marina , Bouzas Luis Fernando Silva , Braga Flávio Henrique  Paraguassu 
Published: August 2015

Objetivo (s): analisar a relação entre celularidade do sangue do cordão umbilical e placentário de gestantes hipertensas e não hipertensas. Método: estudo caso-controle, com abordagem quantitativa, amostra de 73 gestantes, no período de março/2011 a setembro/2011. Os dados fazem de pesquisa aprovada pelo Comitê de Ética em Pesquisa sob o protocolo de número 126/10. Resultados: foi concluído que 80% das bolsas de sangue de cordão umbilical e placentário coletados de gestantes com hipertensão arterial apresentaram celularidade ≥5 x 108, quantidade adequada no total de células nucleadas, atendendo aos critérios estabelecidos pela Resolução 56. Conclusão: os resultados contribuíram para a identificação de fatores que possibilitam a obtenção de um quantitativo adequado de células tronco-hematopoiéticas, resultando no aumento do número de transplantes de células tronco-hematopoiéticas no Brasil. Descritores: Hipertensão Induzida pela Gravidez; Sangue Fetal; Células-Tronco Hematopoéticas; Placenta.