bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bladder cancer discussed on the internet: a systematic analysis of gender differences of initial posters on an online discussion board
Authors: Lippka Yannick , Patschan Oliver , Todenhöfer Tilmann , Schwentner Christian , Gutzeit Andreas , Merseburger Axel S , Horstmann Marcus 
Published: September 2013

Abstract

Objectives
To evaluate gender differences of initial posters in threads dealing with bladder cancer on an online discussion board.

Method
529 threads opened between 09/2005 and 03/2012 were screened on the largest German speaking bladder cancer online discussion board. 366 threads fulfilled the requirements for this study. Gender, age, number, status of concern and oncological situation of initiating posters as well as their motives and language style were analyzed following a standardized protocol.

Results
Threads were initiated in 45% (164/366) by men and in 55% (202/366) by women. Mean age of male initiating posters was 50 years and of female posters 44 years (p < 0.001). Of males 80% (132/164) were concerned patients and 20% (32/164) relatives or friends. Of females they were 39% (78/202) and 61% (124/202), respectively (p < 0.001). In general motives for initial posting were focused on medical information and did not differ between both genders. 81% of the posters asked for medical information or therapeutic recommendations regarding diagnosis, treatment and prognosis. However, women significantly more often expressed their wish for emotional support (p = 0.034) and in tendency wanted to share their experiences with others (p = 0.057). Language analysis revealed that women significantly more often used a tentative language style than men (p = 0.003).

Conclusion
Even though women are less often affected by bladder cancer, they are more active –especially for their concerned family members - on the evaluated discussion board than men. Whereas both genders equally often ask for medical information, women more often want to share their experiences and look for emotional support.
Behavioral study of piston manufacturing plant through stochastic models
Authors: Lal Arvind K , Kaur Manwinder , Lata Sneh 
Published: September 2013

Abstract
Piston plays a vital role in almost all types of vehicles. The present study discusses the behavioral study of a piston manufacturing plant. Manufacturing plants are complex repairable systems and therefore, it is difficult to evaluate the performance of a piston manufacturing plant using stochastic models. The stochastic model is an efficient performance evaluator for repairable systems. In this paper, two stochastic models and computation algorithm of the piston manufacturing plant are illustrated using the state-space transition diagram and availability parameter is used for its behavioral study. Finally, the conclusion is discussed based on the resulting computations.
Androgen deficiency in male patients diagnosed with ANCA-associated vasculitis: a cause of fatigue and reduced health-related quality of life?
Authors: Tuin Janneke , Sanders Jan-Stephan F , Buhl Birgit M , van Beek André P , Stegeman Coen A 
Published: September 2013

Abstract
Introduction
Low testosterone levels in men are associated with fatigue, limited physical performance and reduced health-related quality of life (HRQOL); however, this relationship has never been assessed in patients with anti-neutrophil cytoplasmic antibodies (ANCA) -associated vasculitides (AAV). The aim of this study was to assess the prevalence of androgen deficiency and to investigate the role of testosterone in fatigue, limited physical condition and reduced HRQOL in men with AAV.

Methods
Male patients with AAV in remission were included in this study. Fatigue and HRQOL were assessed by the multi-dimensional fatigue inventory (MFI)-20 and RAND-36 questionnaires.

Results
Seventy male patients with a mean age of 59 years (SD 12) were included. Scores of almost all subscales of both questionnaires were significantly worse in patients compared to controls. Mean total testosterone and free testosterone levels were 13.8 nmol/L (SD 5.6) and 256 pmol/L (SD 102), respectively. Androgen deficiency (defined according to Endocrine Society Clinical Practice Guidelines) was present in 47% of patients. Scores in the subscales of general health perception, physical functioning and reduced activity were significantly worse in patients with androgen deficiency compared to patients with normal androgen levels. Testosterone and age were predictors for the RAND-36 physical component summary in multiple linear regression analysis. Testosterone, age, vasculitis damage index (VDI) and C-reactive protein (CRP) were associated with the MFI-20 subscale of general fatigue.

Conclusions
This study showed that androgen deficiency was present in a substantial number of patients with AAV. Testosterone was one of the predictors for physical functioning and fatigue. Testosterone may play a role in fatigue, reduced physical performance and HRQOL in male patients with AAV.
Perioperative goal-directed hemodynamic therapy based on radial arterial pulse pressure variation and continuous cardiac index trending reduces postoperative complications after major abdominal surgery: a multi-center, prospective, randomized study
Authors: Salzwedel Cornelie , Puig Jaume , Carstens Arne , Bein Berthold , Molnar Zsolt , Kiss Krisztian , Hussain Ayyaz , Belda Javier , Kirov Mikhail Y , Sakka Samir G , Reuter Daniel A 
Published: September 2013

Abstract
Introduction
Several single-center studies and meta-analyses have shown that perioperative goal-directed therapy may significantly improve outcomes in general surgical patients. We hypothesized that using a treatment algorithm based on pulse pressure variation, cardiac index trending by radial artery pulse contour analysis, and mean arterial pressure in a study group (SG), would result in reduced complications, reduced length of hospital stay and quicker return of bowel movement postoperatively in abdominal surgical patients, when compared to a control group (CG).

Methods
160 patients undergoing elective major abdominal surgery were randomized to the SG (79 patients) or to the CG (81 patients). In the SG hemodynamic therapy was guided by pulse pressure variation, cardiac index trending and mean arterial pressure. In the CG hemodynamic therapy was performed at the discretion of the treating anesthesiologist. Outcome data were recorded up to 28 days postoperatively.

Results
The total number of complications was significantly lower in the SG (72 vs. 52 complications, p = 0.038). In particular, infection complications were significantly reduced (SG: 13 vs. CG: 26 complications, p = 0.023). There were no significant differences between the two groups for return of bowel movement (SG: 3 vs. CG: 2 days postoperatively, p = 0.316), duration of post anesthesia care unit stay (SG: 180 vs. CG: 180 minutes, p = 0.516) or length of hospital stay (SG: 11 vs. CG: 10 days, p = 0.929).

Conclusions
This multi-center study demonstrates that hemodynamic goal-directed therapy using pulse pressure variation, cardiac index trending and mean arterial pressure as the key parameters leads to a decrease in postoperative complications in patients undergoing major abdominal surgery.

Trial registration
ClinicalTrial.gov, NCT01401283.
Body temperature patterns as a predictor of hospital-acquired sepsis in afebrile adult intensive care unit patients: a case-control study
Authors: Drewry Anne M , Fuller Brian M , Bailey Thomas C , Hotchkiss Richard S 
Published: September 2013

Abstract
Introduction
Early treatment of sepsis improves survival, but early diagnosis of hospital-acquired sepsis, especially in critically ill patients, is challenging. Evidence suggests that subtle changes in body temperature patterns may be an early indicator of sepsis, but data is limited. The aim of this study was to examine whether abnormal body temperature patterns, as identified by visual examination, could predict the subsequent diagnosis of sepsis in afebrile critically ill patients.

Methods
Retrospective case-control study of 32 septic and 29 non-septic patients in an adult medical and surgical ICU. Temperature curves for the period starting 72 hours and ending 8 hours prior to the clinical suspicion of sepsis (for septic patients) and for the 72-hour period prior to discharge from the ICU (for non-septic patients) were rated as normal or abnormal by seven blinded physicians. Multivariable logistic regression was used to compare groups in regard to maximum temperature, minimum temperature, greatest change in temperature in any 24-hour period, and whether the majority of evaluators rated the curve to be abnormal.

Results
Baseline characteristics of the groups were similar except the septic group had more trauma patients (31.3% vs. 6.9%, p = .02) and more patients requiring mechanical ventilation (75.0% vs. 41.4%, p = .008). Multivariable logistic regression to control for baseline differences demonstrated that septic patients had significantly larger temperature deviations in any 24-hour period compared to control patients (1.5°C vs. 1.1°C, p = .02). An abnormal temperature pattern was noted by a majority of the evaluators in 22 (68.8%) septic patients and 7 (24.1%) control patients (adjusted OR 4.43, p = .017). This resulted in a sensitivity of 0.69 (95% CI [confidence interval] 0.50, 0.83) and specificity of 0.76 (95% CI 0.56, 0.89) of abnormal temperature curves to predict sepsis. The median time from the temperature plot to the first culture was 9.40 hours (IQR [inter-quartile range] 8.00, 18.20) and to the first dose of antibiotics was 16.90 hours (IQR 8.35, 34.20).

Conclusions
Abnormal body temperature curves were predictive of the diagnosis of sepsis in afebrile critically ill patients. Analysis of temperature patterns, rather than absolute values, may facilitate decreased time to antimicrobial therapy.
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation
Authors: de la Rica Lorenzo , Rodríguez-Ubreva Javier , García Mireia , Islam Abul BMMK , Urquiza José M , Hernando Henar , Christensen Jesper , Helin Kristian , Gómez-Vaquero Carmen , Ballestar Esteban 
Published: September 2013

Abstract
Background
DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-fate decisions. Local deposition and removal of DNA methylation are tightly coupled with transcription factor binding, although the relationship varies with the specific differentiation process. Conversion of monocytes to osteoclasts is a unique terminal differentiation process within the hematopoietic system. This differentiation model is relevant to autoimmune disease and cancer, and there is abundant knowledge on the sets of transcription factors involved.

Results
Here we focused on DNA methylation changes during osteoclastogenesis. Hypermethylation and hypomethylation changes took place in several thousand genes, including all relevant osteoclast differentiation and function categories. Hypomethylation occurred in association with changes in 5-hydroxymethylcytosine, a proposed intermediate toward demethylation. Transcription factor binding motif analysis revealed an over-representation of PU.1, NF-κB, and AP-1 (Jun/Fos) binding motifs in genes undergoing DNA methylation changes. Among these, only PU.1 motifs were significantly enriched in both hypermethylated and hypomethylated genes; ChIP-seq data analysis confirmed its association to both gene sets. Moreover, PU.1 interacts with both DNMT3b and TET2, suggesting its participation in driving hypermethylation and hydroxymethylation-mediated hypomethylation. Consistent with this, siRNA-mediated PU.1 knockdown in primary monocytes impaired the acquisition of DNA methylation and expression changes, and reduced the association of TET2 and DNMT3b at PU.1 targets during osteoclast differentiation.

Conclusions
The work described here identifies key changes in DNA methylation during monocyte-to-osteoclast differentiation and reveals novel roles for PU.1 in this process.
Effects of combined pharmacotherapy and psychotherapy for improving work functioning in major depressive disorder
Authors: Lam Raymond W. , Parikh Sagar V. , Ramasubbu Rajamannar , Michalak Erin E. , Tam Edwin M. , Axler Auby , Yatham Lakshmi N. , Kennedy Sidney H. , Manjunath Chinnapalli V. 
Published: September 2013

BackgroundMajor depressive disorder is associated with significant impairment in occupational functioning and reduced productivity, which represents a large part of the overall burden of depression.AimsTo examine symptom-based and work functioning outcomes with combined pharmacotherapy and psychotherapy treatment of major depressive disorder.MethodEmployed patients with a DSM-IV diagnosis of major depressive disorder were treated with escitalopram 10–20mg/day and randomised to: (a) telephone-administered cognitive-behavioural therapy (telephone CBT) (n = 48); or (b) adherence-reminder telephone calls (n = 51). Outcomes included the Montgomery-åsberg Depression Rating Scale (MADRS), administered by masked evaluators via telephone, and self-rated work functioning scales completed online. (Registered at clinicaltrials.gov: NCT00702598.)ResultsAfter 12 weeks, there were no significant between-group differences in change in MADRS score or in response/remission rates. However, participants in the telephone-CBT group had significantly greater improvement on some measures of work functioning than the escitalopram-alone group.ConclusionsCombined treatment with escitalopram and telephone- administered CBT significantly improved some self-reported work functioning outcomes, but not symptom-based outcomes, compared with escitalopram alone.
“They envision going to New York, not Jakarta”: the differing attitudes toward ELF of students, teaching assistants, and instructors in an English-medium business program in Japan
Authors: Galloway Nicola , Rose Heath 
Published: September 2013

Abstract
This study examines attitudes in a bilingual business degree program at a Japanese university, where visiting senior and postgraduate international students are hired to assist sophomore students in the classroom. The visiting international students' role is to not only help students understand business concepts in the course, but to provide opportunity for real life English as a Lingua Franca (ELF) use as well as exposure to the English used by people from varied backgrounds. The study uses a mixed method of questionnaires with 120 students within the program, a focus group with the assistants, and a focus group with the course instructors. The study found that both the students and student assistants had largely positive attitudes to this classroom experience – both in terms of exposure to the diversity of English and the opportunity to use ELF. Furthermore, the study revealed students were acutely aware of their probable future usage of English in lingua franca settings – despite teachers' assumptions that the students would adhere to traditional native English speaker stereotypes, which are often promoted in Japanese language education.
The Auspiciousness of the Performative Body – Ritual Dancing in Folk-Religious Festivals in Japan
Authors: Köpping Klaus-Peter 
Published: September 2013

Abstract The Hanamatsuri and Shimotsukimatsuri of the Southern Japanese Alps are investigated in regard to the diversity of resonances emerging from the performance of these rituals. While the declared aim of these dance rituals is the continuity and renewal of fertility and well-being of nature and humans, it emerges during repeated comparative research in over half of the still extant festivals that the final aim is the re-establishing of communal solidarity. While the much contested objective of these revived dance rituals is the “divine possession”, the underlying notion of well-being or auspiciousness fits very well into other Japanese religious practices to contribute to the maintenance of peaceful social relations. Nevertheless, the contingency of the emergence of divine possession seems to be dependent on lay personnel being in charge of the liturgy as much as on the synesthetic performance’s resonance to generate an affective bodily engagement among all participants. It is argued that even the often criticized increasing influx of city tourists may lead to a new orientation in the self-understanding of the performances as inducing a body imagery which stresses interpersonal “gut-relations” (hara) as a form to escape the daily conventionality of behavioral codes of conduct.
Whose Festival is it?
Authors: Lee William 
Published: September 2013

Abstract This article examines traditional Japanese festivals (matsuri) and the problems they face in remaining socially relevant today by focusing on patterns of participation. While many such festivals continue to follow historical precedent, others have evolved and adapted to current social and demographic trends. Through an analysis of three historically related festivals that have taken rather divergent paths in the modern era, this study attempts to demonstrate how change, including the easing and restructuring of rights of participation, can have beneficial effects. The result can be a modern matsuri which, while still retaining many traditional elements, is capable of engaging a large number of participants and providing them with an emotionally satisfying festival experience.
Rituelle Modulation, Liminalität und die nembutsu-Praxis im ländlichen Japan
Authors: Traphagan John W. 
Published: September 2013

Abstract Der vorliegende Artikel untersucht die nembutsu-Kulte im ländlichen Japan der Gegenwart und argumentiert, dass ihre Rituale eine Form der religiösen Praxis darstellen, die der Verortung von Individuen im sozialen und physischen Raum dient. Die Erforschung der nembutsu-Rituale gibt uns meiner Meinung nach eine Möglichkeit an die Hand, den Begriff der Liminalität als eine Art der Modulation zu re-interpretieren, d. h. als einen Prozess, innerhalb dessen die Teilnehmer von einem ursprünglichen Status in einen neuen Status überführt werden, der viele der Eigenschaften und Kennzeichen des alten Status beibehält. Das in dieser Arbeit behandelte Ritual stellt insofern ein Beispiel solcher Modulationspraxis dar, als die Beziehungen sowohl zwischen den Toten und den Lebenden als auch zwischen den Lebenden untereinander in einer Weise umstrukturiert werden, die diese Beziehungen verändert, dabei aber viele ihrer ursprünglichen Elemente aufrechterhält.
The “Performance” of Kyōgen.
Authors: Zehbe Klaus 
Published: September 2013

Abstract By bringing Schechner’s analytical concepts of ‘script’, ‘theater’ and ‘performance’ (2003) to bear on the analysis of a contemporary performance of Kyōgen, a form of traditional Japanese theatre, and by examining the play and interplay of these three dimensions through Turner’s theory of ritual (2005), I will discuss how performances of Kyōgen present notions and topoi of individual and collective well-being and may actually contribute to a state thereof. In doing so, I aim to arrive at a better understanding of what the notion of well-being may mean for Japanese people.
Well-being and Risk-taking Behavior.
Authors: Wulf Alexander J. 
Published: September 2013

Abstract This article describes risk taking and well-being in corporate Japan. A case study of a research intensive manufacturing company shows how a corporate management can design its business strategy to contribute to the well-being of the employees. An in-depth expert interview with the company’s Chief Executive Officer and a qualitative content analysis of official company documents present and discuss the firm’s employee well-being policy. Findings show that the organization employs its business philosophy to promote a working environment that encourages constructive risk-taking. This leads to technological innovations and improved competitiveness on the market. Furthermore, the company is successful in contributing to the well-being of its employees and other stakeholders.
2D-Stromverteilungen und ihre Magnetfelder: ein Beispiel-Problem / 2D Current Distributions and Their Magnetic Fields: A Showcase Problem
Authors: Hofer Dominik , Zagar Bernhard G. 
Published: September 2013

Zusammenfassung
Magnetfeldmessung für wenig Geld findet heute in jedem Smartphone statt. Dieser Artikel widmet sich dem wissenschaftlicheren Einsatz handelsüblicher Kompass-ICs. So können diese Bausteine z. B. in der zerstörungsfreien Werkstoffprüfung oder bei Strommessungen verlässliche Messdaten liefern, auch wenn die anschließende Interpretation dieser Datenflut neue Herausforderungen mit sich bringt. Konkret wird im folgenden Text die 2D Stromverteilung in einer Leiterbahn betrachtet. Auch wenn die Problemstellung simpel klingen mag, die Lösung des inversen Problems - des Findens der Stromdichten hinter den Messwerten - stellt sich als komplex heraus.
Schnelle Röntgentomographie zur zeitlich aufgelösten Messung von Geschwindigkeiten in Strömungen / Fast X-Ray Tomography for Time-Resolved Measurements of Flow Velocities
Authors: Hoppe Dietrich 
Published: September 2013

Zusammenfassung
Ein gegebener schneller Röntgentomograph mit zwei parallelen Messebenen dient zur örtlich aufgelösten Messung von Geschwindigkeiten. Seine Aufgabe soll ohne technischen Zusatzaufwand auf zeitlich aufgelöste Messungen ausgedehnt werden. Der Ebenenabstand ist dafür aber zu groß. Deshalb wird zusätzlich eine indirekte Messebene definiert, indem diejenige Strahlung ausgenutzt wird, die sich im Tomographen zwischen den regulären Ebenen ausbreitet. Die neue Messebene hat zu einer der regulären Ebenen einen genügend kleinen Abstand. Wie damit gemessen werden kann, verdeutlicht ein praktisches Beispiel.
Elektronisches Messsystem zur Strukturzustandsüberwachung / Electronic Measurement System for Structural Health Monitoring
Authors: Heinzelmann Andreas , Dürager Christian 
Published: September 2013

Zusammenfassung
Zur Überwachung von Faserverbundlösungen aus kohle- oder glasfaserverstärktem Kunststoff sind neue Ansätze notwendig. Der Artikel beschreibt ein elektronisches Messsystem zur integrierten Strukturzustandsüberwachung. Neben dem universalen Einsatz werden im ersten Teil der Aufbau des Systems sowie die mess- und signaltechnischen Eigenschaften beschrieben. In zweiten Teil wird die algorithmische Auswertung der Messsignale mit der „Empirical Mode Decomposition“-Methode erläutert. Mit der Ellipsen- Triangulationsmethode lassen sich in einem Versuchsaufbau Schädigungen durch Hagelkörner mit einem Durchmesser von 2 cm in einer Karbonplatte mit einem Durchmesser von 1m und einer Dicke von 1mm auf 3mm genau lokalisieren.