bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival pattern in male breast cancer: distinct from female breast cancer
Authors: Gwark Sungchan , Kim Jisun , Chung Il Yong , Kim Hee Jeong , Ko Beom Seok , Lee Jong Won , Son Byung Ho , Ahn Sei Hyun , Lee Sae Byul 
Published: June 2024

IntroductionMale breast cancer (MBC) is a rare condition, and recent research has underscored notable distinctions between MBC and breast cancer in women. This study aimed to assess and contrast the long-term survival outcomes and disease patterns of MBC patients with those of their female counterparts.MethodsWe analyzed data from 113,845 patients diagnosed with breast cancer who had undergone curative surgery from the Korean Breast Cancer Registry (KBCR) between January 1990 and August 2014 in Seoul, Korea. The five-year overall survival was analyzed according to clinicopathological characteristics.ResultsAmong 113,845 patients with breast cancer, 473 MBC cases were included. The median duration of follow-up was 72 months. The median age at diagnosis was 60 and 48 years for MBC and female breast cancer, respectively. Most male patients (92.6%) underwent total mastectomy, while 50.4% of female patients underwent breast-conserving surgery. Among MBC, 63.2% received chemotherapy, and 83.9% of hormone receptor-positive male patients received endocrine therapy. In survival analysis, MBC demonstrated distinct 5-year overall survival patterns compared with female breast cancer, according to age at diagnosis. In women with breast cancer, the younger age group (≤40 years) demonstrated worse 5-year overall survival than did the older age group (&gt;40 years) (91.3% vs 92.7%, p &lt;0.05). While in MBC, the younger age group (≤40 years) demonstrated better 5-year overall survival than did the older age group (&gt;40 years) (97.4% vs 86.4%, p &lt;0.05).DiscussionIn conclusion within this extensive cohort, we have revealed unique survival patterns in MBC that diverge from those observed in women with breast cancer. This study enhances our comprehension of MBC prognosis and can potentially shed light on unresolved questions, paving the way for future research in the realm of MBC.
Psyllium fiber improves hangovers and inflammatory liver injury by inhibiting intestinal drinking
Authors: Yang Keungmo , Ryu Tom , Chung Beom Sun 
Published: June 2024

Introduction: Excessive alcohol intake often results in hangovers and inflammatory liver damage, posing a significant health concern. Current treatment options for hangovers are still insufficient, highlighting the urgent need for new therapeutic approaches. Psyllium fiber (PF) is well-known for its gastrointestinal benefits, but its effect on hangovers is less explored.Methods: We utilized a mouse model with a single binge drinking (4 g/kg) to induce hangover and inflammatory liver injury. Intestine and liver injury were serologically and histologically estimated. Hangover symptoms were assessed using cylinder and footprint tests to objectively quantify hangover symptoms in mice.Results: Binge drinking significantly activated alcohol-metabolizing enzymes in the small intestine and liver, leading to inflammatory damage. Concurrently, there was a rise in alcohol metabolites such as acetaldehyde and acetone, which exhibited a positive correlation with hangover symptoms in mice. Interestingly, the oral administration of PF (100 mg/kg) alongside alcohol consumption significantly reduced the activity of these enzymes and lowered the levels of alcohol metabolites. Mice treated with PF exhibited a considerable improvement in hangover symptoms and a reduction in hepatic inflammation, compared to control groups. Furthermore, in vitro experiments using HepG2 cell lines and semipermeable membranes demonstrated that PF effectively inhibits alcohol absorption into the body.Discussion: In conclusion, PF demonstrates a potential protective effect against alcohol-induced hangover and liver injury by inhibiting the absorption of alcohol and lowering hangover-related alcohol metabolites. This study suggests that PF could serve as an effective therapeutic option for mitigating the adverse effects of excessive alcohol consumption.
Effects of different types of physical exercise on executive function of older adults: a scoping review
Authors: Cai Zhidong , Cai Ruibao , Sen Li 
Published: June 2024

ObjectiveThis scoping review examined the impact of physical exercise on executive function (EF) in older adults and investigated the moderating effects of exercise types.MethodsWe systematically searched four electronic databases for randomized controlled trials (RCTs) investigating the effects of exercise on EF, published until November 26, 2023. The proportions of positive and null/negative effects across all studies were calculated.ResultsIn total, 91 studies were included in the analysis. Among these, 27 (29.7%) studies employed aerobic exercise interventions for older adults’ EF, with 19 (70.4%) studies reporting positive effects. Additionally, 18 (19.8%) studies utilized strength exercise interventions for older adults’ EF, with 15 (83.3%) studies demonstrating positive benefits. Furthermore, 32 (35.2%) studies employed coordination exercise interventions for older adults’ EF, with 25 (78.1%) studies showing positive benefits. Similarly, 30 (33%) studies applied mixed exercise interventions for older adults’ EF, with 25 (83.3%) studies indicating positive benefits.ConclusionOverall, all four types of physical exercise enhance EF in older adults, with mixed exercises being the most effective.
The mediating role of mentalization and integrative self-knowledge in the relationship between childhood trauma and fear of intimacy
Authors: Riazi Seyyedeh Sara , Manouchehri Mehdi 
Published: June 2024

IntroductionSince intimacy is a fundamental human need within social relationships, and recognizing that a fear of intimacy correlates with various negative consequences, it becomes crucial to examine the origins and factors that contribute to addressing this issue. This research aimed to investigate the mediating roles of mentalization and integrative self-knowledge in the link between childhood trauma and the fear of intimacy.MethodsConducted as correlational descriptive research, our study incorporates a total sample of 303 adult women and men participants aged 20 to 50 in Tehran using the convenience sampling method. They completed the Fear of Intimacy Scale (FIS), the Childhood Trauma Questionnaire (CTQ), the Mentalization Scale (MentS), and the Integrative Self-Knowledge Scale (ISK). To analyze the research data at the descriptive level, frequency, percentage, standard deviation, and Pearson’s correlation coefficient were used, while path analysis tested our hypotheses in SPSS version 26 and AMOS version 24. Fit indices were used to check the model’s fit, and the mediation test was performed using the bootstrapping method. The fit indices revealed an excellent fit of the model with the data (χ2 = 1.51, χ2/df = 1.51, p = 0.219; RMSEA = 0.05; SRMR = 0.02; CFI = 0.99; NFI = 0.99; TLI = 0.99).ResultsResults indicate mentalization fully mediates the childhood trauma-fear of intimacy relationship (β = 0.14, p &lt; 0.01). However, the indirect relationship between childhood trauma and fear of intimacy through integrative self-knowledge was insignificant. The results also showed that the path coefficient from mentalization to fear of intimacy was negative and significant (β = −0.41, p &lt; 0.001), while the path coefficient from integrative self-knowledge to fear of intimacy was not significant (β = −0.02, p &gt; 0.05).DiscussionBased on the current findings indicating the complete mediation of mentalization and the insignificance of the mediation of integrative self-knowledge, we can deduce that enhancing the capacity for mentalization holds promise in effectively addressing intimacy-related issues. Overall, the study suggests mentalization effectively predicts the relationship between childhood trauma and fear of intimacy. This, in turn, may mitigate the detrimental effects of challenging childhood experiences on an individual’s ability to engage in intimacy and cultivate emotional closeness.
Feasibility study to unveil the potential: considerations of constrained spherical deconvolution tractography with unsedated neonatal diffusion brain MRI data
Authors: Verschuur Anouk S. , Tax Chantal M. W. , Boomsma Martijn F. , Carlson Helen L. , van Wezel-Meijler Gerda , King Regan , Leemans Alexander , Leijser Lara M. 
Published: June 2024

PurposeThe study aimed to (1) assess the feasibility constrained spherical deconvolution (CSD) tractography to reconstruct crossing fiber bundles with unsedated neonatal diffusion MRI (dMRI), and (2) demonstrate the impact of spatial and angular resolution and processing settings on tractography and derived quantitative measures.MethodsFor the purpose of this study, the term-equivalent dMRIs (single-shell b800, and b2000, both 5 b0, and 45 gradient directions) of two moderate-late preterm infants (with and without motion artifacts) from a local cohort [Brain Imaging in Moderate-late Preterm infants (BIMP) study; Calgary, Canada] and one infant from the developing human connectome project with high-quality dMRI (using the b2600 shell, comprising 20 b0 and 128 gradient directions, from the multi-shell dataset) were selected. Diffusion tensor imaging (DTI) and CSD tractography were compared on b800 and b2000 dMRI. Varying image resolution modifications, (pre-)processing and tractography settings were tested to assess their impact on tractography. Each experiment involved visualizing local modeling and tractography for the corpus callosum and corticospinal tracts, and assessment of morphological and diffusion measures.ResultsContrary to DTI, CSD enabled reconstruction of crossing fibers. Tractography was susceptible to image resolution, (pre-) processing and tractography settings. In addition to visual variations, settings were found to affect streamline count, length, and diffusion measures (fractional anisotropy and mean diffusivity). Diffusion measures exhibited variations of up to 23%.ConclusionReconstruction of crossing fiber bundles using CSD tractography with unsedated neonatal dMRI data is feasible. Tractography settings affected streamline reconstruction, warranting careful documentation of methods for reproducibility and comparison of cohorts.
Radiographic and echocardiographic evaluation in rescued Korean raccoon dogs (Nyctereutes procyonoides koreensis)
Authors: Park Junu , Kim Myeongsu , Han Jae-Ik , Lee Kichang , Yoon Hakyoung 
Published: June 2024

IntroductionNyctereutes procyonoides koreensis (Korean raccoon dog), a member of the Canidae family, is anatomically similar to dogs. Previous studies have used vertebral heart scale measurements to measure the cardiac size of Korean raccoon dogs on thoracic radiographs; however, the use of additional cardiac size indices, such as vertebral left arial score, intercostal space, cardiothoracic ratio, and echocardiographic indices, has not been reported. Therefore, this study aimed to establish normal reference ranges for various thoracic radiographic and echocardiographic indices in normal Korean raccoon dogs.MethodsTwenty-six Korean raccoon dogs (11 males and 15 females) were included in this study. The thoracic radiographic indices, vertebral heart scale score, and vertebral left atrial score were measured in the right lateral view. The intercostal space and cardiothoracic ratio were measured in the ventrodorsal view. The echocardiograms were evaluated in the right parasternal long and short axis view and left parasternal apical view.ResultsThe mean values for the thoracic radiographic and echocardiographic indices were as follows: vertebral heart scale, 9.12 ± 0.74; vertebral left atrial score, 1.5 ± 0.31; intercostal spaces, 3.17 ± 0.34; cardiothoracic ratio, 0.69 ± 0.07; left atrial to aortic root ratio, 1.22 ± 0.14; main pulmonary artery to aorta ratio, 1.22 ± 0.14; left ventricular end-diastolic internal diameter normalized for body weight, 1.36 ± 0.19; end-diastolic volume index, 51.07 ± 19.6; end-systolic volume index, 16.54 ± 7.45; the peak velocity of early diastolic transmitral flow, 73.13 ± 15.46 cm/s; and the ratio between the transmitral flow velocities and the peak early diastolic velocity, 1.77 ± 0.47. Only percent increase in the left ventricular end-systolic internal diameter was negatively correlated with body weight. The remaining indices showed no correlations with body weight.ConclusionTo the best of our knowledge, this is the first case report covering both thoracic radiographic and endocardiographic indices for Korean raccoon dogs. Thus, the thoracic radiographic and echocardiographic indices established in this study may be used to evaluate the cardiac condition of Korean raccoon dogs.
HIỆU QUẢ HOẠT ĐỘNG CỦA CÁC BỘ MÔN SAU TÁI CẤU TRÚC TẠI TRƯỜNG ĐẠI HỌC NÔNG LÂM – ĐẠI HỌC THÁI NGUYÊN
Authors: Ngân Nguyễn Thị , Tính Nguyễn Quang , Huyền Vương Vân , Quyên Đỗ Thị Ngọc , Quỳnh Lê Thị , Thuy Nguyễn Thị 
Published: June 2024

Bài viết nhằm đánh giá hiệu quả hoạt động của các bộ môn thuộc các khoa chuyên môn của Trường Đại học Nông Lâm, Đại học Thái Nguyên sau 3 năm tái cấu trúc lại các bộ môn. Ở thời điểm trước tháng 4 năm 2019, tổng số bộ môn của 8 khoa trong trường là 38 bộ môn, sau tái cấu trúc còn 20 bộ môn (giảm được 18 bộ môn). Chương trình khảo sát lấy ý kiến về hiệu quả hoạt động của các Bộ môn sau tái cấu trúc được thực hiện bằng bảng câu hỏi gồm 44 câu hỏi theo hình thức online, sau khi triển khai lấy ý kiến đánh giá, kết quả đã nhận được 177 phiếu trả lời khảo sát từ các giảng viên trong nhà trường. Kết quả có 92,7% ý kiến đánh giá việc tái cấu trúc là rất phù hợp; Bộ môn chủ động trong tất cả các hoạt động liên quan đến ngành/chuyên ngành được quản lý; việc triển khai thực hiện công tác đào tạo, nghiên cứu khoa học và các công việc khác của bộ môn hiệu quả hơn rõ rệt. Như vậy, việc tái cấu trúc lại các bộ môn đã giúp tinh gọn bộ máy, nâng cao chất lượng đào tạo, nghiên cứu khoa học của đơn vị nói riêng và của nhà trường nói chung.
Economic Growth in the Era of Economic Openness in Indonesia
Authors: Larasati Dewi Trisna , Sulistyono Setyo Wahyu 
Published: June 2024

The global economy has entered economic globalization, where with this economic globalization there is an escalation of the openness of a country's economy to international trade, foreign investment and international capital flows. Economic openness in both the financial sector and trade relations can be used as a driver of economic growth. Indonesia is one of the countries that continues to strive to become a developed nation. Indonesia has experienced significant development, particularly in the economic sector. This progress is evident through a relatively good economic growth. The objective of this research is to examine the impact of petroleum and natural gas exports, petroleum and natural gas imports, foreign direct investment (FDI), and foreign exchange reserves on the economic growth of Indonesia's Gross Domestic Product (GDP) from 1990 to 2022. In terms of methodology, this study employed quantitative descriptive approaches and utilized secondary data for analysis. The data collection method uses the documentation method or documentation study using multiple linear regression analysis methods. The findings indicated that the exportation of petroleum and natural gas had a notable adverse impact on the economic growth of Gross Domestic Product (GDP). While petroleum and natural gas imports, foreign direct investment (FDI) and foreign exchange reserves make a positive and significant contribution to Gross Domestic Product (GDP). The implication of this study underscores the significance of considering the roles played by petroleum and natural gas export, petroleum and natural gas import, foreign direct investment, and foreign exchange reserves in shaping economic policies in Indonesia.
Knowledge and Attitude towards Vaginoplasty and Perineoplasty among Jordanian Females
Authors: Al Qerem Walid A. , Alassi Ameen , Alazab Jumana , Alazab Badi’ah , Eberhardt Judith , Kalloush Hanin Moh’d , Alarwany Rahaf , Jarab Anan s. 
Published: June 2024

Introduction: The global increase in female genital cosmetic surgery (FGCS), including procedures like vaginoplasty and perineoplasty, has raised concerns regarding their safety and effectiveness. Therefore, this study aimed to address this gap by assessing the knowledge and attitudes of Jordanian females towards vaginoplasty and perineoplasty.
Study design: A cross-sectional online survey was conducted among 522 Jordanian females aged 18 or older.
Methods: Quantile regression models were employed to identify variables associated with females’ knowledge and attitudes towards vaginoplasty and perineoplasty.
Results: The study revealed a low level of knowledge regarding vaginoplasty and perineoplasty, despite positive attitudes towards these surgeries. Significant associations were found between knowledge levels and both age and occupation. Similarly, attitudes were significantly associated with age and socioeconomic status.
Discussion: These findings underscore the need for targeted educational campaigns to enhance awareness about these procedures and their associated risks. Moreover, there should be a focus on evaluating physician-patient communication to ensure informed decision-making.
Service-Learning in the Context of Karol Wojtyła’s Theory of Participation
Authors: Ecler-Nocoń Beata , Kozubek Mariola Teresa , Cinque Maria 
Published: June 2024

Objectives of the research: The aim of this article is to explore how Karol Wojtyła’s theory of participation can enhance our understanding of ‘Service Learning’ (SL) and its potential benefits for education and personal development resulting from the implementation of SL in higher education.
Research methods: The research was based on an analysis of publications on Service-Learning, a hermeneutic examination of Karol Wojtyła’s writings on participation, and a case study using SL.
A short description of the context of the issue: Service-Learning is defined as reflection and action to transform reality, as serving in solidarity with the application of learning content and as learning by serving the community. This article presents the principles of Service-Learning through community participation, exposing the benefits of this approach in education.
Research findings: Karol Wojtyła’s theory of participation serves as a creative inspiration for the theoretical basis of Service-Learning. Its principles can introduce SL project participants to personalistic values. The concepts of service, community, common good, solidarity, dialogue and opposition play a key role in this confrontation. By combining service with the learning process, SL can contribute to the development of project participants in terms of both knowledge and social skills.
Conclusions and recommendations: In drawing conclusions regarding the potential benefits of implementing the Service-Learning method in education, the authors emphasise that values, in accordance with Wojtyła’s philosophy, are a key element of personal and social development. In the context of SL, people can find fulfilment through relationships with others, which is the answer to contemporary educational challenges. The authors recommend further research into different forms of SL implementation in order to better understand and maximise its potential in fostering participation and social service.
Efektivitas Anti Mikroba Air Ion Perak terhadap Derajat Keasaman (pH) Streptococcus mutans
Authors: Setiawati Herautami C. Y. , Wicaksono Dimas P. , Dewi Ardianti M. , Sinaredi Betadion 
Published: June 2024

Abstract: Silver ion water has been known as an effective material for inhibiting and killing pathogenic bacteria. However, there are still few studies on silver ion water, especially those related to oral pH in dentistry. This study aimed to determine the effectiveness of silver ion water against Streptococcus mutans in decreasing the environmental pH. This was an experimental and laboratory study with a control group post-test only design, using Streptococcus mutans stereotype C strain UA 159 incubated in brain hearth infusion broth (BHIB). Samples were divided into eight groups with several concentrations of silver ion water (2.5 ppm, 5 ppm, 7.5 ppm,10 ppm, 12,5 ppm, 15 ppm) and two control groups (silver ion water 0 ppm and aquadest). All groups were incubated for 24 hours in 37oC, and then their pHs were measured with a pH meter. The normality test showed a p-value of >0.05, meaning that the data were normally distributed. The Mann-Whitney test showed a p-value of <0.05, meaning that there was a difference in each group. Significant increases of pH were found in silver ion water of 12.5 ppm (mean pH 5.670) dan 15 ppm (mean pH 6.772). In conclusion, silver ion water of 12.5 ppm and 15 ppm can effectively inhibit the decrease in pH caused by the metabolism of Streptococcus mutans.
Keywords: silver ion water; Streptococcus mutans; pH

Abstrak: Air ion perak telah dikenal efektif untuk menghambat dan membunuh bakteri patogen, namun penelitian tentang air ion perak masih sangat terbatas, terutama yang berhubungan dengan pH rongga mulut di bidang kedokteran gigi. Penelitian ini bertujuan untuk mengetahui efektivitas air ion perak menghambat Streptococcus mutans dalam menurunkan pH. Jenis penelitian ialah eksperimental laboratorik dengan group control post-test only design, menggunakan Streptococcus mutans stereotype C rantai UA 159 yang diinkubasi di dalam media brain hearth infusion broth (BHIB). Sampel dibagi dalam delapan kelompok, masing-masing diberi air ion perak sebanyak 2,5 ppm, 5 ppm, 7,5 ppm, 10 ppm, 12,5 ppm, 15 ppm, dan dua kelompok kontrol (air ion perak 0 ppm dan akuades). Seluruh kelompok perlakuan dan kontrol diinkubasi selama 24 jam dengan suhu 37oC, kemudian pH-nya diukur menggunakan pH meter. Uji normalitas menunjukkan p<0,05 yang berarti data berdistribusi normal. Uji Mann Whitney menunjukkan p<0,05 yang berarti terdapat perbedaan bermakna antar kelompok perlakuan. Efek peningkatan derajat keasaman (pH) yang bermakna terlihat pada pemberian air ion perak sebanyak 12,5 ppm (rerata pH 5,670) dan 15 ppm (rerata pH 6,772). Simpulan penelitian ini ialah air ion perak dengan konsentrasi 12,5 ppm dan 15 ppm efektif menghambat penurunan pH yang disebabkan oleh metabolism Streptococcus mutans.
Kata kunci: air ion perak; Streptococcus mutans; pH