bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Personalized Sexual Medicine (Part 3): Testosterone Combined with a Serotonin1A Receptor Agonist Increases Sexual Satisfaction in Women with HSDD and FSAD, and Dysfunctional Activation of Sexual Inhibitory Mechanisms
Authors: van Rooij Kim , Poels Saskia , Bloemers Jos , Goldstein Irwin , Gerritsen Jeroen , van Ham Diana , van Mameren Frederiek , Chivers Meredith , Everaerd Walter , Koppeschaar Hans , Olivier Berend , Tuiten Adriaan 
Published: November 2012

ABSTRACT

Introduction
Among other causes, low sexual desire in women may result from dysfunctional activation of sexual inhibition mechanisms during exposure to sex. Administration of sublingual 0.5 mg testosterone (T) increases the sensitivity of the brain to sexual cues, which might amplify sexual inhibitory mechanisms further in women already prone to sexual inhibition. Sexual stimulation might elicit a prefrontal cortex (PFC)-mediated phasic increase in sexual inhibition, in which activity of 5-hydroxytryptamine (5-HT, serotonin) is involved. A single dose of 5-HT1A receptor agonist (5-HT1Ara) might reduce the sexual stimulation induced PFC-mediated sexual inhibition during a short period after administration. Consequently, treatment with a single dose of T+5-HT1Ara might enhance sexual responsiveness, particularly in women exhibiting sexual inhibition.

Aim
To investigate if treatment with a single dosage of T+5-HT1Ara will produce improvement in sexual functioning in women with Hypoactive Sexual Desire Disorder (HSDD) as the result of dysfunctional high sexual inhibition.

Methods
Fifty-four women were divided on the basis of their excitatory or inhibitory responses during T+phosphodiesterase type 5 inhibitor (PDE5i) in low (N = 26) and high inhibitors (N = 28). Physiological and subjective indices of sexual functioning were measured in a participant-controlled ambulatory psychophysiological experiment at home (the first week of each drug treatment). In a bedroom experiment (the subsequent 3 weeks), sexual functioning was evaluated by event, week, and monthly diaries.

Main Outcome Measures
Subjective: sexual satisfaction, experienced genital arousal, sexual desire. Physiological: vaginal pulse amplitude.

Results
Women with high inhibition show a marked improvement in sexual function in response to treatment with T+5-HT1Ara relative to placebo and relative to T+PDE5i.

Conclusions
The present study demonstrated that on-demand T+5-HT1Ara is a potentially promising treatment for women with HSDD, particularly for those women who are prone to sexual inhibition.
Toward Personalized Sexual Medicine (Part 2): Testosterone Combined with a PDE5 Inhibitor Increases Sexual Satisfaction in Women with HSDD and FSAD, and a Low Sensitive System for Sexual Cues
Authors: Poels Saskia , Bloemers Jos , van Rooij Kim , Goldstein Irwin , Gerritsen Jeroen , van Ham Diana , van Mameren Frederiek , Chivers Meredith , Everaerd Walter , Koppeschaar Hans , Olivier Berend , Tuiten Adriaan 
Published: November 2012

ABSTRACT

Introduction
Low sexual desire in women may result from a relative insensitivity of the brain for sexual cues. Administration of sublingual 0.5 mg testosterone (T) increases the sensitivity of the brain to sexual cues. Sexual stimulation in the brain is necessary for phosphodiesterase type 5 inhibitor (PDE5i)-mediated increase in genital sexual response. Accordingly, a single dose of T+PDE5i might enhance sexual responsiveness, especially in women with low sensitivity for sexual cues.

Aim
To assess the hypothesis that treatment with on-demand use of T+PDE5i improves sexual functioning, particularly in women who suffer from Hypoactive Sexual Desire Disorder (HSDD) as the result of a relative insensitivity for sexual cues.

Methods
In a randomized, double-blind, placebo-controlled, crossover design, 56 women with HSDD underwent three medication treatment regimes (placebo, T+PDE5i, and T with a serotonin 1A receptor agonist; see also parts 1 and 3), which lasted 4 weeks each. In a participant-controlled ambulatory psychophysiological experiment at home (the first week of each drug treatment), physiological and subjective indices of sexual functioning were measured. In a bedroom experiment (the subsequent 3 weeks), sexual functioning was evaluated following each sexual event after the self-administration of study medication. Subjective evaluation of sexual functioning was also measured by weekly and monthly reports.

Main Outcome Measures
Subjective: sexual satisfaction, experienced genital arousal, sexual desire. Physiological: vaginal pulse amplitude. Cognitive: preconscious attentional bias.

Results
T+PDE5i, as compared with placebo, significantly improved physiological and subjective measures of sexual functioning during ambulatory psychophysiological lab conditions at home and during the sexual events, in women with low sensitivity for sexual cues.

Conclusions
The present study demonstrated that on-demand T+PDE5i is a potentially promising treatment for women with HSDD, particularly in women with low sensitivity for sexual cues.
The Interconnected Self: The Social Individual is More Than Just Social + Individual
Authors: Gabriel Shira , Harris Brianna , Carvallo Mauricio , Troisi Jordan D. 
Published: November 2012

AbstractAlthough decades of research provide consistent evidence supporting the perspective that the self is divided into social and personal components each with unique and predictable motivational associations, the current paper argues that something important has been overlooked. Specifically, what has been lost is the acknowledgment that although different components of self can be activated, and can have important implications, the two aspects of self are highly interconnected. Specifically in this paper, it is argued that (i) the independent self is affected by social motivations and (ii) the social self is affected by independent motivations. Two studies are presented in support of these hypotheses. We conclude by comparing our perspective with existing theories of the self and by discussing implications for the study of the self.
Sleep and Affective Brain Regulation
Authors: van der Helm Els , Walker Matthew P. 
Published: November 2012

AbstractRapidly emerging evidence continues to describe an intimate and causal relationship between sleep and affective brain regulation. These findings are mirrored by long‐standing clinical observations demonstrating that nearly all mood and anxiety disorders co‐occur with one or more abnormalities of sleep. This review aims to (1) provide a synthesis of recent human evidence describing affective brain and behavioral benefits of sleep when it is obtained, and conversely, detrimental impairments following a lack thereof, (2) set forth a rapid eye movement sleep hypothesis of affective brain homeostasis, optimally preparing the organism for next‐day social and emotional functioning, and (3) outline how this model may explain the prevalent relationships observed between sleep and affective disorders, including relevant treatment mechanisms, with a particular focus on post‐traumatic stress disorder (PTSD).
An Intricate Dance: Life Experience, Multisystem Resiliency, and Rate of Telomere Decline Throughout the Lifespan
Authors: Puterman Eli , Epel Elissa 
Published: November 2012

AbstractAccumulation of life stressors predicts accelerated development and progression of diseases of aging. Telomere length, the DNA‐based biomarker indicating cellular aging, is a mechanism of disease development, and is shortened in a dose response fashion by duration and severity of life stressor exposures. Telomere length captures the interplay between genetics, life experiences and psychosocial and behavioral factors. Over the past several years, psychological stress resilience, healthy lifestyle factors, and social connections have been associated with longer telomere length and it appears that these factors can protect individuals from stress‐induced telomere shortening. In the current review, we highlight these findings, and illustrate that combining these ‘multisystem resiliency’ factors may strengthen our understanding of aging, as these powerful factors are often neglected in studies of aging. In naturalistic studies, the effects of chronic stress exposure on biological pathways are rarely main effects, but rather a complex interplay between adversity and resiliency factors. We suggest that chronic stress effects can be best understood by directly testing if the deleterious effects of stress on biological aging processes, in this case the cell allostasis measure of telomere shortening, are mitigated in individuals with high levels of multisystem resiliency. Without attending to such interactions, stress effects are often masked and missed. Taking account of the cluster of positive buffering factors that operate across the lifespan will take us a step further in understanding healthy aging. While these ideas are applied to the telomere length literature for illustration, the concept of multisystem resiliency might apply to aging broadly, from cellular to systemic health.
Social Representations of Gender in Peer Interaction and Cognitive Development
Authors: Psaltis Charis 
Published: November 2012

AbstractThe paper discusses how social representations of gender and their development in childhood relate to the structuring of communication on collaborative problem solving in the educational context and the consequences of such communication dynamics for learning and cognitive development. In the theoretical framework and the empirical work outlined an emphasis is given on the articulation of different levels of analysis (intra‐personal, inter‐personal, inter‐group/positional and ideological/social representations) (Doise, W. 1986. Levels of Explanation in Social Psychology: European Monographs in Social Psychology. Cambridge: Cambridge University Press) in a way that explanatory power is increased for understanding the often contradictory findings in the literature around gender talk in mixed‐sex dyads in the educational context.
Prevalence and impact of xerostomia on the quality of life of people living with HIV/AIDS from Brazil
Authors: Busato Ivana Maria Saes , Thomaz Mariana , Toda Alexandre Issamu , Alanis Danilo Gustavo Pulita , França Beatriz Helena Sottile , de Lima Antônio Adilson Soares , Azevedo‐Alanis Luciana Reis 
Published: November 2012

ABSTRACTObjective: To evaluate the impact of xerostomia on the quality of life (QOL) of people living with HIV/AIDS (PLWHA) from Brazil. Study Design: A cross‐sectional study was performed on 195 PLWHA. Xerostomia was detected by asking a question about the sensation of having “dry mouth,” and Oral Health Impact Profile 14 (OHIP‐14) was used to measure the impact of xerostomia on QOL. Time of diagnosis of HIV/AIDS was assessed. Results: A total of 78 (40.0%) subjects presented with xerostomia. Xerostomia was associated with female gender, low amount of saliva perceived (p ≤ .01), difficulty in swallowing food (p ≤ .05), and showed to have a negative impact on QOL as measured by OHIP‐14 (p ≤ .01). Conclusion: Xerostomia was frequent and showed to have a negative impact on the QOL of PLWHA.
Health Problems and Male Firearm Suicide
Authors: Hempstead Katherine , Nguyen Tuan , David‐Rus Richard , Jacquemin Bretta 
Published: November 2012

Drawing on constructs of masculinity as it relates to both gun ownership and men's health, we use a rich data set, the New Jersey Violent Death Reporting System as well as hospital discharge data, to analyze 3,413 completed male suicides between the years of 2003 and 2009. We test the hypotheses that the use of firearms is more common when physical health problems are cited as suicide circumstances, and that suicide decedents who use firearms have poorer physical health than those who used other methods. Results show that firearms are disproportionately used in male suicides when physical health is listed as a circumstance. Additionally, among suicide decedents with a hospitalization during the 3 years prior to death, those who used firearms were in poorer health than those who used other methods. These findings have implications for prevention efforts, because restricting access to lethal means is an important aspect of suicide prevention.
Comparative in vitro antibacterial activity of six root canal sealers against Enterococcus faecalis and Proteus vulgaris
Authors: Farmakis Eleftherios‐Terry R. , Kontakiotis Evangelos G. , Tseleni‐Kotsovili Aggelina , Tsatsas Vasilios G. 
Published: November 2012

AbstractAimTo evaluate the antimicrobial properties of six endodontic sealers in unset and set states against Enterococcus faecalis and Proteus vulgaris.MethodsSix endodontic sealers were investigated in the unset and set state against Enterococcus feacalis and Proteus vulgaris using agar diffusion and direct contact tests.ResultsThe mean inhibition zones for agar diffusion tests with Enterococcus feacalis were 19 mm for AH‐26, 11 mm for TopSeal and Roth 601, 1 mm for AH‐Plus, and 0 mm for GuttaFlow and EndoREZ (Kruskal–Wallis, P < 0.001). The mean inhibition zones with Proteus vulgaris were 24 mm for Roth 601, 19 mm for TopSeal, 17 mm for AH‐Plus, 16 mm for AH‐26, and 0 mm for GuttaFlow and EndoREZ (Kruskal–Wallis, P < 0.001). Direct contact tests showed inhibition of both Enterococcus feacalis and Proteus vulgaris with AH‐Plus, TopSeal, Roth 601, and AH‐26 in the unset state. Only Roth 601 in the set state affected both the log and the stationary phase of Proteus vulgaris (logistic regression P < 0.001).ConclusionsWith the exception of Roth 601, which retained its antimicrobial activity, the AH‐Plus, TopSeal, and AH‐26 sealers all demonstrated antimicrobial properties against Enterococcus feacalis and Proteus vulgaris that diminished when set. TopSeal significantly affected Enterococcus feacalis when compared with AH‐Plus. GuttaFlow and EndoREZ expressed no antimicrobial activity.
Abdominal ultrasonography of the normalSt.Kitts vervet monkey (Chlorocebus sabaeus)
Authors: Amory J.T. , Du Plessis W.M. , Beierschmitt A. , Beeler‐Marfisi J. , Palmour R.M. , Beths T. 
Published: November 2012

AbstractBackgroundNormal ultrasonography of non‐reproductive abdominal and male reproductive anatomy in the vervet monkey were prospectively assessed. This has not been previously reported.MethodsTen non‐sexually active male and 10 non‐gravid female clinically healthy vervet monkeys between 5 and 12 years of age and weighing between 3.13 and 6.85 kg were evaluated with ultrasound. Individuals were randomly divided by gender groups into one of two immobilization protocols and scanned at 18.0 MHz.ResultsHigh‐quality images of the liver, gallbladder, kidneys, urinary bladder, spleen, adrenal glands, gastrointestinal tract, and testes were acquired. The prostate was never visualized. Abdominal lymph nodes other than an ileocolic, the pancreas, and the female reproductive tract were not evaluated. Gastric and duodenal motility were significantly different between immobilization protocols (P < 0.05).ConclusionsAbdominal sonographic anatomy was successfully characterized and normal size parameters for non‐reproductive abdominal viscera and the testes were established.
It's Not Just What We Encode, but How We Encode It: Associations Between Neuroticism and Learning
Authors: Byrom Nicola C. , Murphy Robin A. 
Published: November 2012

AbstractObjectiveNeuroticism is a strong predictor of future mental health problems. The informativeness of this association has been questioned because of the limited understanding of the mechanisms underlying Neuroticism. In this article the authors extend our understanding of the association between information processing and Neuroticism.MethodTwo independent studies involving separate sets of college students (N = 89 and N = 33), use self‐rated Neuroticism scores to compare individuals' ability to learn simple and more complex discriminations, between simple shapes and words presented alone and in compound.ResultsNeuroticism was found to be associated with differences in learning to discriminate simple stimuli from compounds containing the same simple stimuli. Individuals with high levels of Neuroticism appeared to process compounds of stimuli as whole units even when this ceased to be an effective strategy for learning. In contrast, individuals with lower levels of Neuroticism performed better with discriminations that could be solved while learning about separate stimuli, rather than compounds.ConclusionsThe authors discuss possible mechanisms of learning identified by these tasks and consider what implications their observations have for an understanding of the relationship between Neuroticism and mental health problems.
Melatonin, melatonin isomers and stilbenes in Italian traditional grape products and their antiradical capacity
Authors: Vitalini Sara , Gardana Claudio , Simonetti Paolo , Fico Gelsomina , Iriti Marcello 
Published: November 2012

AbstractAlthough polyphenols represent the paradigm of the health‐promoting effects ascribed to grape products, recently, attention has been paid to dietary melatonin, significantly present in Mediterranean foods. In this work, we measured melatonin, its isomers, stilbenes (trans‐ and cis‐resveratrol and their glucosides, piceids) and total polyphenols in some different grape products (red, white and dessert wines, grape juices and Modena balsamic vinegars) of distinct Italian areas. We also evaluated their antiradical activity by DPPH· and ABTS·+ assays. For indoleamine analysis, the separation was carried out on a 1.7‐μm C18 BEH column and the detection performed by means of mass spectrometry with electrospray ionization in positive ion mode with multiple reaction monitoring. The confirmation of the peak identity was accomplished by injection into the high‐resolution system (Orbitrap) using accurate mass measurements (error below 1.0 ppm). Mass spectrometry analyses revealed, for the first time, the presence of melatonin in dessert wines and balsamic vinegars, as well as the occurrence of three different melatonin isomers in grape products.
The Global Dimension of Inflation – Evidence from Factor‐Augmented Phillips Curves*
Authors: Eickmeier Sandra , Pijnenburg Katharina 
Published: November 2012

AbstractWe examine the global dimension of inflation in 24 OECD countries between 1980 and 2007 in a Phillips curve framework. We decompose output gaps and changes in unit labour costs into common (or global) and idiosyncratic components using a factor analysis and introduce these components separately in the regression. We find that the common component of changes in unit labour costs has a notable impact on inflation. Movements in import price inflation (not driven by oil supply) and foreign competition and global interest rate developments also affect inflation. Policy makers need to carefully observe those variables when assessing inflation developments.
Microbial interactions in building of communities
Authors: Wright C.J. , Burns L.H. , Jack A.A. , Back C.R. , Dutton L.C. , Nobbs A.H. , Lamont R.J. , Jenkinson H.F. 
Published: November 2012

SummaryEstablishment of a community is considered to be essential for microbial growth and survival in the human oral cavity. Biofilm communities have increased resilience to physical forces, antimicrobial agents and nutritional variations. Specific cell‐to‐cell adherence processes, mediated by adhesin‐receptor pairings on respective microbial surfaces, are able to direct community development. These interactions co‐localize species in mutually beneficial relationships, such as streptococci, veillonellae, Porphyromonas gingivalis and Candida albicans. In transition from the planktonic mode of growth to a biofilm community, microorganisms undergo major transcriptional and proteomic changes. These occur in response to sensing of diffusible signals, such as autoinducer molecules, and to contact with host tissues or other microbial cells. Underpinning many of these processes are intracellular phosphorylation events that regulate a large number of microbial interactions relevant to community formation and development.
Migraine Treated Using a Prophylactic Combination of Candesartan and Hydrochlorothiazide (ECARD® Combination Tablets LD)
Authors: Akiyama Hisanao , Hasegawa Yasuhiro 
Published: November 2012

AbstractWe describe the use of the antihypertensive, candesartan, with hydrochlorothiazide (ECARD® Combination Tablets LD) as a preventive therapy that decreased the frequency of migraine accompanied by premonitory leg edema. Two women (aged 26 and 50 years) presented to hospital with an increasing frequency of migraine without aura accompanied by leg edema. We prescribed ECARD® half tablet (candesartan, 2 mg and hydrochlorothiazide, 3.125 mg), and the migraines and leg edema disappeared. The use of ECARD® to treat a series of migraines by controlling premonitory leg edema has not been reported. ECARD®, combined with a low‐dose diuretic, may have been helpful in these patients with the premonitory migraine symptom of leg edema.
Deciphering the message of Early Cretaceous drowning surfaces from the Helvetic Alps: What can be learnt from platform to basin correlations?
Authors: Godet Alexis , Föllmi Karl B. , Spangenberg Jorge E. , Bodin Stéphane , Vermeulen Jean , Adatte Thierry , Bonvallet Lucie , Arnaud Hubert 
Published: November 2012

AbstractDrowning unconformities are a frequent feature of carbonate platforms and generally express the incapacity of shallow‐marine ecosystems to adapt to abrupt sea‐level rise and/or palaeoenvironmental change. During the late Hauterivian and early Barremian, the Helvetic carbonate platform experienced a major drowning phase documented by the phosphate and glauconite‐rich Altmann Member. It has been shown that a drowning unconformity in the form of a hardground at the base of the Altmann Member on the Pilatus summit (central Switzerland) results from a complex, polyphased diagenetic history that includes two main phases of phosphogenesis. Using carbon‐isotope stratigraphy, biostratigraphy and sequence stratigraphy, the correlation of this drowning unconformity from the Helvetic domain with more distal and more complete sedimentary archives allows reconstruction of the sequence‐stratigraphic context of the drowning surface, and also an estimation of the amount of time represented by the episodes of condensation. Unconformities associated with the Altmann Member drowning phase developed during transgressive episodes, when strong currents arrived onto the previously subaerially exposed platform, and periods of phosphogenesis may have lasted up to 2·8 Myr. Variations in trophic levels and hitherto less well‐known intervening emersion phases played an essential triggering role for the Altmann drowning phase. High‐resolution studies of drowning unconformities unravel the diversity of palaeoenvironmental parameters involved in the unfolding of such crises during the evolution of carbonate platforms.