bluuebunny/crossref_metadata_2025_split huggingface dataset:
A parametric assessment approach to solving facility‐location problems with fuzzy demands
Authors: Lin Pei‐Chun , Watada Junzo , Wu Berlin 
Published: June 2014

AbstractIn real‐world applications, sometimes randomness and fuzziness may coexist. In facility‐location problems, the data expressed in natural language may contain vague information. We discuss the uncertainty included in demands in facility‐location problems. The uncertain demand is called fuzzy demand in this paper. In the facility‐location model, the parameters of fuzzy demand are determined by calculating the estimated expected value of the fuzzy demand, which is obtained by using the estimated parameters of the underlying probability distribution function of the fuzzy data. Moreover, we propose a defuzzification formula of the fuzzy demand called the realization of fuzzy demand. The defuzzification formula of fuzzy demand comprises the upper bound and the lower bound of the fuzzy demand. Moreover, the error of the fuzzy demand is assessed as the mean absolute percentage error of the fuzzy demand. Empirical studies show that we can solve real‐life location problems by using the defuzzification formula of fuzzy demand and get higher profit in our facility‐location model than by using conventional methods. © 2014 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Synthesis and Protonation Studies of Molybdenum(0) Bis(di­nitrogen) Complexes Supported by Diphosphine Ligands ­Containing Pendant Amines
Authors: Labios Liezel A. , Weiss Charles J. , Egbert Jonathan D. , Lense Sheri , Bullock R. Morris , Dougherty William G. , Kassel W. Scott , Mock Michael T. 
Published: June 2014

Abstract A series of molybdenum bis(dinitrogen) complexes of the formula trans‐[Mo(N2)2(PEtNRPEt)2] (PEtNRPEt = Et2PCH2N(R)CH2PEt2; R = phenyl (1), 2,6‐difluorobenzyl (2), 3,5‐difluorobenzyl (3), CH2CH2NMe2 (4), CH2‐o‐Py (5)] were synthesized and characterized by NMR and IR spectroscopy, and X‐ray crystallography. Protonation studies with stoichiometric amounts of triflic acid (HOTf) were performed, and the protonated products were characterized by NMR and in situ IR spectroscopic methods. Products formed in the stepwise protonation reactions included, for example, a mixture of the seven‐coordinate molybdenum bis(dinitrogen) hydride, trans‐[Mo(H)(N2)2(PEtNPhPEt)2]+ [1H]+, and the Mo‐hydrazido triflate complex, trans‐[Mo(NNH2)(OTf)(PEtNPhPEt)2]+ [1(NNH2)]+. Complex 2, with more basic pendant amines, can be protonated up to three times, affording the highly‐charged molecule, trans‐[Mo(H)(N2)2(PEtN2,6‐F2‐Bn(H)PEt)2)]3+ [2H(PN(H)P)2]3+.
Destructive Effect of an α‐Particle on TEX
Authors: Türker Lemi 
Published: June 2014

AbstractBy computational studies it was found that interaction of an α‐particle with TEX (an explosive molecule having a cage structure) disturbs the molecular skeleton dramatically. As the α‐particle exerts its positive electrostatic field, the C–C bond between the dioxalane rings present in TEX breaks down forming the dication of TEX. The calculation were done within the constraints of the density functional theory at the level of B3LYP using various bases sets, mainly 6‐31++G(d,p).
Parkinsonism and inborn errors of metabolism
Authors: Garcia‐Cazorla A. , Duarte S. T. 
Published: June 2014

AbstractParkinsonism is a frequent neurological syndrome in adulthood but is very rare in childhood. Early forms of Parkinsonism have many distinctive features as compared to Parkinsonism in adults. In fact, rather than Parkinsonism, the general concept “hypokinetic‐rigid syndrome” (HRS) is more accurate in children. In general, the terms “dystonia‐parkinsonism”, “parkinsonism‐plus”, or “parkinsonism‐like” are preferred to designate these forms of paediatric HRS. Inborn errors of metabolism (IEM) constitute an important group amongst the genetic causes of Parkinsonism at any age. The main IEM causing Parkinsonism are metal‐storage diseases, neurotransmitter defects, lysosomal storage disorders and energy metabolism defects. IEM should not be neglected as many of them represent treatable causes of Parkinsonism. Here we review IEMs causing this neurological syndrome and propose diagnostic approaches depending on the age of onset and the associated clinical and neuroimaging features.
Effectiveness of enzyme replacement therapy in adults with late‐onset Pompe disease: results from the NCS‐LSD cohort study
Authors: Anderson L. J. , Henley W. , Wyatt K. M. , Nikolaou V. , Waldek S. , Hughes D. A. , Lachmann R. H. , Logan S. 
Published: June 2014

AbstractObjectivesTo determine the effectiveness of enzyme replacement therapy (ERT) for adults with late‐onset Pompe disease.DesignA longitudinal cohort study including prospective and retrospective clinical outcome data. Age‐ and gender‐adjusted treatment effects were estimated using generalised linear mixed models. Treated patients contributed data before and during treatment. Untreated patients contributed natural history data.ParticipantsConsenting adults (N = 62) with a diagnosis of late‐onset Pompe disease who attended a specialist treatment centre in England. This cohort represented 83 % of all patients in the UK with a confirmed diagnosis of this rare condition. At study entry, all but three patients were receiving ERT (range of treatment duration, 0 to 3.1 years).Outcome measuresPercent predicted forced vital capacity (%FVC); ventilation dependency; mobility; 6 min walk test (6MWT); muscle strength and body mass index (BMI).ResultsAn association was found between time on ERT and significant increases in the distance walked in the 6MWT (p < 0.001) and muscle strength scores (p < 0.001). Improvements in both these measures were seen over the first 2 years of treatment with ERT. No statistically significant relationship was found between time on ERT and respiratory function or in BMI.ConclusionsThese data provide some further evidence of the effectiveness of ERT in adults with late‐onset Pompe disease.SynopsisThe results of this longitudinal cohort study of 62 adults with late‐onset Pompe disease, provide further evidence on the effectiveness of ERT in this rare condition.
Compartment Syndrome: Diagnosis, Management, and Unique Concerns in the Twenty-First Century
Authors: Garner Matthew R. , Taylor Samuel A. , Gausden Elizabeth , Lyden John P. 
Published: June 2014

Background Compartment syndrome is an elevation of intracompartmental pressure to a level that impairs circulation. While the most common etiology is trauma, other less common etiologies such as burns, emboli, and iatrogenic injuries can be equally troublesome and challenging to diagnose. The sequelae of a delayed diagnosis of compartment syndrome may be devastating. All care providers must understand the etiologies, high-risk situation, and the urgency of intervention. Questions/Purposes This study was conducted to perform a comprehensive review of compartment syndrome discussing etiologies, risk stratification, clinical progression, noninvasive and invasive monitoring, documentation, medical-legal implication, and our step-by-step approach to compartment syndrome prevention, detection, and early intervention. Methods A literature search was performed using the PubMed Database and the following search terms: “Compartment syndrome AND Extremity,” “Compartment syndrome AND Gluteal,” and Compartment syndrome AND Paraspinal.” A total of 2,068 articles were identified. Filters allowed for the exclusion of studies not printed in English (359) and those focusing on exertional compartment syndrome (84), leaving a total of 1,625 articles available for review. Results The literature provides details regarding the etiologies, risk stratification, clinical progression, noninvasive and invasive monitoring, documentation, medical-legal implication, and our step-by-step approach to compartment syndrome prevention, detection, and early intervention. The development and progression of compartment syndrome is multifactorial, and as complexity of care increases, the opportunity for the syndrome to be missed is increased. Recent changes in the structure of in-hospital medical care including resident work hour restrictions and the incorporation of midlevel providers have increased the frequency of “signouts” or “patient handoffs” which present opportunities for the syndrome to be mismanaged. Conclusion The changing dynamics of the health care team have prompted the need for a more explicit algorithm for managing patients at risk for compartment syndrome to ensure appropriate conveyance of information among team members.
The Synergism of Biochemical Components Controlling Lipid Oxidation in Lamb Muscle
Authors: Ponnampalam Eric N. , Norng Sorn , Burnett Viv F. , Dunshea Frank R. , Jacobs Joe L. , Hopkins David L. 
Published: June 2014

AbstractLipid oxidation of M. longissimus lumborum in fresh or vacuum packaged (aged) lamb meat stored at 3 °C for 0 or 4 weeks, respectively and displayed under refrigerated conditions for a further 4 days was assessed by measuring the concentration of malondialdehyde (MDA) in meat using the thiobarbituric acid reactive substances procedure. The effects of vitamin E, heme iron and polyunsaturated fatty acids (n‐6 and n‐3) on lipid oxidation were examined. Results showed a strong positive relationship between heme iron, n‐6 and n‐3 fatty acids and lipid oxidation when vitamin E was below 2.95 mg/kg muscle. When lipid oxidation was related to vitamin E concentration and the other three variables, respectively, any increase in heme iron or n‐6 or n‐3 fatty acids concentration did not influence lipid oxidation. Management of diet to elevate muscle vitamin E concentration above 3.45 mg/kg muscle is beneficial to maintain the level of lipid oxidation below 2.4 mg MDA/kg muscle in meat stored for up to 4 weeks. This demonstrates that vitamin E concentration in muscle has a greater influence on controlling lipid oxidation in muscle tissues than do heme iron or polyunsaturated fatty acids.
Father–daughter relationship and the severity of eating disorders
Authors: Horesh N. , Sommerfeld E. , Wolf M. , Zubery E. , Zalsman G. 
Published: June 2014

AbstractBackground:Mother–daughter relationship was the focus of studies on the development of eating disorders (ED) for many years. This study aimed to examine the association between the father–daughter relationship and ED and depressive symptoms.Methods:Fifty-three women diagnosed with ED were compared to a psychiatric control group (n= 26) and to healthy participants (n= 60) regarding their perception of their fathers and the relationship with them. Assessments were done using the Parental Bonding Instrument, the Eating Disorders Questionnaire, the Body Shape Questionnaire, the Eating Attitude Test, and the Beck Depression Inventory as well as narrative-based methods.Results:Fathers’ negative attributes were significantly associated with ED and depressive symptom. Two profiles of father–daughter relationship were found, the “caring and benevolent” relationship and the “overprotective and avoidant” one. In the latter, patients displayed significantly higher levels of food-restraint, more concerns about eating and about their body shape and appearance, and higher levels of depression.Discussion:Negative perception of the father's parenting style as well as the quality of the relationship with him are crucial for the understanding of the development and persistence of ED. Therapeutic programs for ED should focus not only on the relationship with the mother but must also address the relationship with the father.
Links between sleep and body mass index in bipolar disorders: An exploratory study
Authors: Boudebesse C. , Geoffroy P.-A. , Henry C. , Germain A. , Scott J. , Lajnef M. , Leboyer M. , Bellivier F. , Etain B. 
Published: June 2014

AbstractStudy objectives:Obesity and excess bodyweight are highly prevalent in individuals with bipolar disorders (BD) and are associated with adverse consequences. Multiple factors may explain increased bodyweight in BD including side effects of psychotropic medications, and reduced physical activity. Research in the general population demonstrates that sleep disturbances may also contribute to metabolic burden. We present a cross-sectional study of the associations between body mass index (BMI) and sleep parameters in patients with BD as compared with healthy controls (HC).Methods:Twenty-six French outpatients with remitted BD and 29 HC with a similar BMI completed a 21-day study of sleep parameters using objective (actigraphy) and subjective (PSQI: Pittsburgh Sleep Quality Index) assessments.Results:In BD cases, but not in HC, higher BMI was significantly correlated with lower sleep efficiency (P = 0.009) and with several other sleep parameters: shorter total sleep time (P = 0.01), longer sleep onset latency (P = 0.05), higher fragmentation index (P = 0.008), higher inter-day variability (P = 0.05) and higher PSQI total score (P = 0.004).Conclusions:The findings suggest a link between a high BMI and several sleep disturbances in BD, including lower sleep efficiency. Physiological mechanisms in BD cases may include an exaggeration of phenomena observed in non-clinical populations. However, larger scale studies are required to clarify the links between metabolic and sleep-wake cycle disturbances in BD.
The optimal setting of complex fractionated atrial electrogram software in substrate ablation for atrial fibrillation
Authors: Namino Fuminori , Iriki Yasuhisa , Maenosono Ryuichi , Ichiki Hitoshi , Okui Hideki , Yoshimura Akino , Oketani Naoya , Matsushita Masakaze , Ohishi Mitsuru , Hashiguchi Teruto 
Published: June 2014

AbstractBackgroundComplex fractionated atrial electrogram (CFAE)‐targeted catheter ablation (CFAE ablation) requires a high rate of atrial fibrillation (AF) termination to provide good outcomes. We determined the optimal settings of CFAE software.MethodsIn our 430 consecutive patients, AF was terminated in 97 (234/242) and 79% (149/188) of patients with paroxysmal and persistent AF, respectively, by CFAE ablation combined with (31%) or without (69%) pulmonary vein isolation, occasionally with nifekalant infusion. We analyzed 109 consecutive patients who underwent CFAE ablation to determine the optimal settings for comparing subjective versus objective decisions by the CFAE software on CARTO3. We compared three settings: the default setting (0.05–0.15 mV, 50–120 ms) and two modified settings (#1: 0.05–0.30 mV, 40–70 ms, #2: 0.05–0.13 mV, 10–20 ms). We retrospectively analyzed 11,425 points during left atrial mapping before ablation and 10,306 points that were subjectively detected and ablated as CFAE points. An interval confidence level ≥6 denoted a site with CFAE.ResultsWith the default setting, the accuracy, sensitivity, specificity, positive productive value, and negative productive values were 67, 42, 77, 48, and 73%, respectively. With modified setting #1, the values were 78, 55, 87, 74, and 77%, respectively, versus 64, 82, 60, 53, and 91%, respectively, for modified setting #2.ConclusionThese data suggest that setting #1 was generally superior to the default setting, whereas setting #2 was optimal for excluding areas not requiring ablation. The optimal CFAE software setting was a voltage of 0.05–0.30 mV and an interval parameter of 40–70 ms.
BRCA2 inhibition enhances cisplatin‐mediated alterations in tumor cell proliferation, metabolism, and metastasis
Authors: Rytelewski Mateusz , Tong Jessica G. , Buensuceso Adrian , Leong Hon S. , Maleki Vareki Saman , Figueredo Rene , Di Cresce Christine , Wu Sherry Y. , Herbrich Shelley M. , Baggerly Keith A. , Romanow Larissa , Shepherd Trevor , Deroo Bonnie J. , Sood Anil K. , Chambers Ann F. , Vincent Mark , Ferguson Peter J. , Koropatnick James 
Published: June 2014

Tumor cells have unstable genomes relative to non‐tumor cells. Decreased DNA integrity resulting from tumor cell instability is important in generating favorable therapeutic indices, and intact DNA repair mediates resistance to therapy. Targeting DNA repair to promote the action of anti‐cancer agents is therefore an attractive therapeutic strategy. BRCA2 is involved in homologous recombination repair. BRCA2 defects increase cancer risk but, paradoxically, cancer patients with BRCA2 mutations have better survival rates. We queried TCGA data and found that BRCA2 alterations led to increased survival in patients with ovarian and endometrial cancer. We developed a BRCA2‐targeting second‐generation antisense oligonucleotide (ASO), which sensitized human lung, ovarian, and breast cancer cells to cisplatin by as much as 60%. BRCA2 ASO treatment overcame acquired cisplatin resistance in head and neck cancer cells, but induced minimal cisplatin sensitivity in non‐tumor cells. BRCA2 ASO plus cisplatin reduced respiration as an early event preceding cell death, concurrent with increased glucose uptake without a difference in glycolysis. BRCA2 ASO and cisplatin decreased metastatic frequency in vivo by 77%. These results implicate BRCA2 as a regulator of metastatic frequency and cellular metabolic response following cisplatin treatment. BRCA2 ASO, in combination with cisplatin, is a potential therapeutic anti‐cancer agent.
Torsional Instability of an Elastic Flat Plate due to Hydrodynamic Loads
Authors: Armandei M. , Fernandes A. C. 
Published: June 2014

AbstractThe present work studies the torsional instability of an elastic structure due to hydrodynamic loads into the water current. The structure applied here is a rectangular flat plate with an elastic axis in its mid-chord length. The elasticity in the structure is provided by torsion spring. The flat plate has only one degree of freedom which is rotation in pure yaw about its axis. Through the free vibration experiments, it is observed that as the current speed exceeds a critical velocity, the flat plate becomes unstable. Two different chord lengths are tested and the instability occurs for a chord base range of Reynolds number, 0.75 × 105< Rec< 1.5 × 105. As a result of the instability, the flat plate begins to yaw about the elastic axis. The hydrodynamic moment acting on the flat plate is modeled by means of the flutter derivatives. As an identification technique to extract flutter derivatives, a curve fitting scheme called General Least-Square (GLS) theory is applied on the results of the free vibration experiments. The results confirm that the structure becomes dynamically unstable due to the hydrodynamic moment applied on it beyond the critical velocity. The super-critical Hopf bifurcation is also discussed in the light of the analysis.
Relationship between stearoyl-CoA desaturase 1 gene expression, relative protein abundance, and its fatty acid products in bovine tissues
Authors: Rezamand Pedram , Watts Jason S , Yavah Katherine M , Mosley Erin E , Ma Liying , Corl Benjamin A , McGuire Mark A 
Published: June 2014

Stearoyl-CoA desaturase 1 (SCD1) greatly contributes to the unsaturated fatty acids present in milk and meat of cattle. The SCD1 enzyme introduces a double bond into certain saturated fatty acyl-CoAs producing monounsaturated fatty acids (MUFA). The SCD1 enzyme also has been shown to be active in the bovine mammary gland convertingt11 18 : 1 (vaccenic acid) toc9t11 conjugated linoleic acid (CLA). The objective of this study was to determine any association between the gene expression ofSCD1 and occurrence of its products (c9 14 : 1,c9 16 : 1,c9 18 : 1, andc9t11 18 : 2) in various bovine tissues. Tissue samples were obtained from lactating Holstein cows (n=28) at slaughter, frozen in liquid nitrogen and stored at −80 °C. Total RNA was extracted and converted to complementary DNA for quantitative real time polymerase chain reaction (PCR) analysis of theSCD1 gene. Extracted lipid was converted to fatty acid methyl esters and analysed by GC. Tissues varied in expression ofSCD1 gene with mammary, cardiac, intestinal adipose, and skeletal muscle expressing greater copy number as compared with lung, large intestine, small intestine and liver (371, 369, 328, 286, 257, 145, 73, and 21 copies/ng RNA, respectively). Tissues with high mRNA expression ofSCD1 contained greater SCD1 protein whereas detection of SCD1 protein in tissues with lowSCD1 mRNA expression was very faint or absent. Across tissues, the desaturase indices forc9 18 : 1 (r=0·24) and sum of SCD products (r=0·20) were positively correlated withSCD1 gene expression (P<0·01 for both). Within each tissue, the relationship betweenSCD1 gene expression and the desaturase indices varied. No correlation was detected betweenSCD1 expression and desaturase indices in the liver, large and small intestines, lung, cardiac or skeletal muscles. Positive correlations, however, were detected betweenSCD1 expression and the desaturase indices in intestinal adipose tissue (P<0·02 for all) except 14 : 1, whereas onlyc9 18 : 1,c9t11 18 : 2 and sum of all desaturase indices were positively correlated withSCD1 expression in mammary tissue (P⩽0·03). Overall, the relationship betweenSCD1 gene expression and occurrence of its products seems to be tissue specific.
CHARACTERIZATIONS OF OPTIMAL POLICIES IN A GENERAL STOPPING PROBLEM AND STABILITY ESTIMATING
Authors: Gordienko Evgueni , Novikov Andrey 
Published: June 2014

We consider an optimal stopping problem for a general discrete-time process X1, X2, …, Xn, … on a common measurable space. Stopping at time n (n = 1, 2, …) yields a reward Rn(X1, …, Xn) ≥ 0, while if we do not stop, we pay cn(X1, …, Xn) ≥ 0 and keep observing the process. The problem is to characterize all the optimal stopping times τ, i.e., such that maximize the mean net gain:
$$E(R_\tau(X_1,\dots,X_\tau)-\sum_{n=1}^{\tau-1}c_n(X_1,\dots,X_n)).$$
We propose a new simple approach to stopping problems which allows to obtain not only sufficient, but also necessary conditions of optimality in some natural classes of (randomized) stopping rules.In the particular case of Markov sequence X1, X2, … we estimate the stability of the optimal stopping problem under perturbations of transition probabilities.
Signals for color and achromatic contrast in the goldfish inner retina
Authors: BURKHARDT DWIGHT A. 
Published: June 2014

AbstractA moving stimulus paradigm was designed to investigate color contrast encoding in the retina. Recently, this paradigm yielded suggestive evidence for color contrast encoding in zebrafish but the significance and generality remain uncertain since the properties of color coding in the zebrafish inner retina are largely unknown. Here, the question of color contrast is pursued in the goldfish retina where there is much accumulated evidence for retinal mechanisms of color vision and opponent color-coding, in particular. Recordings of a sensitive local field potential of the inner retina, the proximal negative response, were made in the intact, superfused retina in the light-adapted state. Responses to color contrast and achromatic contrast were analyzed by comparing responses to a green moving bar on greenversusred backgrounds. The quantitative form of the irradiance/response curves was distinctly different under a range of conditions in 32 retinas, thereby providing robust evidence for red–green color contrast. The color contrast is based on successive contrast, occurs in the absence of overt color opponency, and clearly differs from previous findings in the goldfish retina for simultaneous color contrast mediated by color-opponent neurons. The form of the irradiance/response curves suggests that successive color contrast is particularly important when achromatic contrast is low, as often occurs in natural environments. The present results provide a parallel with the well-known principle of human color vision, first proposed by Kirschmann as the third law of color contrast, and may also have implications for the evolution of vertebrate color vision.