bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence, Risk Factors, and Outcomes of Postoperative Complications Following Splenectomy among Yemeni Patients with Hematological Diseases: A Prospective Cohort Study
Authors: Gailan Waleed Mohammed , Obaidel Yasser Abdurabo , Al-Salat Mahran , Jowah Haitham Mohammed 
Published: August 2024

Abstract

Purpose
This study aimed to evaluate the incidence and types of postoperative complications, identify associated risk factors, and assess their impact on patient outcomes in Yemeni patients undergoing splenectomy for hematological diseases.
Patients and methods:
This prospective observational cohort study was conducted at Kuwait University Hospital in Sana’a, Yemen, from 2022 to 2024. The study included 53 patients of all ages with confirmed hematological diseases requiring splenectomy. Data were collected through clinical assessments, patient interviews, and medical record review.
Results
The mean age of the patients was 11.13 years, with a slight female predominance (54.7%). The most common diagnoses were Thalassemia Major (37.7%) and Sickle Cell Disease (24.5%). Postoperative complications occurred in 53% of patients, with pulmonary complications (26.42%) and surgical site infections (20.75%) the most common. Significant risk factors for complications included older age, specific diagnoses, and diabetes. Pulmonary complications were associated with shorter hospital stays, whereas surgical site infections were associated with longer hospital stays. The readmission and mortality rates were 20.75%, and the mortality rate was 5.66%, with overwhelming post-splenectomy infection (OPSI) and surgical site infections significantly associated with higher mortality rates.
Conclusions
This study demonstrated a high incidence of postoperative complications following splenectomy in Yemeni patients with hematological diseases, which significantly affected patient outcomes. Comprehensive preoperative assessment, specialized care, stringent infection control measures, and vigilant postoperative monitoring are essential for improving surgical outcomes. Further research with larger cohorts is recommended to validate these findings and provide more comprehensive guidelines for managing patients.
Resonant and non-resonant impurity states related to quantum well subbands
Authors: Akimov Volodymyr , Tulupenko Viktor , Demediuk Roman , Tiutiunnyk Anton , Duque Carlos A. , Morales Alvaro L. , Laroze David , Mora-Ramos Miguel Eduardo 
Published: August 2024

Abstract

The energy positions and wave function shapes of ground and excited impurity states including resonant ones are studied using expansion method. The structures under study are GaAs/AlGaAs rectangular quantum wells with four different widths. In all cases impurity binding energy (with respect to related subband) has a maximum at or near the center of the well, decreases when approaching to the barrier and seemingly has a limit of 0 if impurity moves away from the well. If impurity is displaced from the well center, then non-resonant impurity states wave functions within the well move closer to impurity center while the wave functions of the resonant states below the second subband move away from it. The effect is more pronounced for the ground and first resonant states respectively for the wider wells and reaches maximum near the halfway from center to barrier.
Exploring Mathematical Values Held by High School Mathematics Teachers
Authors: Dorwu Esenam , Awuah Francis Kwadwo , Kyeremeh Patrick 
Published: August 2024

Abstract

This current study explored mathematical values espoused by senior high school (SHS) mathematics teachers in mathematics teaching and learning in a municipality in Ghana. In achieving this aim, we employed an explanatory sequential mixed methods design. In the quantitative study, a census was employed to include all 53 SHS mathematics teachers in a municipality. For the qualitative phase, purposive sampling was used to select six SHS mathematics teachers recruited to complete a ‘What I Find Important (WIFI) in my mathematics learning’ questionnaire in the quantitative phase to participate in interviews. The quantitative data were analyzed using inferential statistics (principal components analysis [PCA] with Oblimin rotation and one-way multivariate analysis of variance [MANOVA]). On the other hand, the qualitative data was analyzed using a thematic analysis. Among Bishop’s six-value cluster, the findings revealed that SHS mathematics teachers preferred mathematical values of rationalism, progress, and control in mathematics teaching. Notwithstanding, there was no statistically significant disparity in what SHS mathematics teachers value across class levels. Implications for practice and future research are reported.
A green and sustainable wastewater technology for pollutant removal.
Authors: Halib Abd Allah Al , Hamad Hanai A. M. , tabl Abdou Saad El , Daba Mohamed S. , habbak Eslam El 
Published: August 2024

Abstract

Rapidly growing urbanization industrialization and environmental contamination with chemical and biological pollutants have worsened due to the presence of toxic substances in water, which has led to worldwide problems. The reuse and treatment of wastewater have become important concepts in the attempt to increase water availability to compensate for the demand for water in domestic and industrial activities. Several physiochemical and biological methods have been developed to treat contaminated water; however, treatment methods with maximum efficiency in the removal of all kinds of pollutants are still being developed. Novel water treatment technologies using bioactive sorbent reactors have been developed. Studies have focused on modeling and experimental measurements under laboratory and field conditions. The metal ions were copper(II), nickel(II), cadmium(II), manganese(II), zinc(II), ferric(III), lead(II) and chromium(III). First, the study was held at 27°C in the laboratory using waste water metal ions and different concentration ratios of ligand (L) and metal salts (M), defined as [2L: 1 M] and [2L: 5 M], respectively. The results revealed that the efficiency of heavy metal and bacterial removal was enhanced by increasing the concentration of the ligand relative to the metal salts. At a [2L:1 M] molar ratio of 27°C, the removal efficiency of heavy metals ranged from 10% − 22% after 30 min, increased to 13% − 46% after 60 min, and increased to 6.57%-33% after 30 min and increased to 15%-70% at 60 min. Additionally, the use of a bioactive sorbent system showed that. In the presence of 2.0 g/L for one hour, the COD decreased 96.8%, the TSS decreased 97.7%, the TDS decreased 90.6% and the BOD decreased 95.8% at 27°C, and the heavy metals decreased (75.0%-94.29%). However, after treatment with 2.0 g/L for three hours, the COD decreased 96.93%, the TSS decreased 98.13%, the TDS decreased 93.43% and the BOD decreased 97.17% at 27°C; after one hour, the heavy metal concentration decreased (80.95%-95.99%), and after three hours, the heavy metal concentration decreased (76.0%-94.0%), and the fecal coliform concentration decreased (99.9%). However, after using 4.0 g/L for one hour, the COD decreased 96.97%, the TSS decreased 95.2%, the TDS decreased 90.41%, and the BOD decreased 95.42% at 27°C. When 4.0 g/L was used for three hours, the COD decreased by 97.16%, the TSS decreased by 97.69%, the TDS decreased by 97.67%, and the BOD decreased by 96.95% at 27°C. After one hour, the heavy metal concentration decreased (75.0%-92.1%). However, after three hours, the metal concentration decreased (91.0%-97.0%), and the fecal coliform concentration decreased in both cases (99.9%).
From the Workroom to the Bedroom: Work-to-Home Spillover as a Mechanism Linking Work Characteristics to Sleep Health
Authors: Huang Kian , Mu Christina , Smith Claire , Lee Soomi 
Published: August 2024

Abstract

Work may influence the home domain and subsequently impact employee sleep. Past work found that negative spillover mediated the relationship between perceived unfairness about work and insomnia symptoms across 20 years. As an extension of past work, this study investigated whether negative spillover and positive spillover mediate the relationship between job demands (perceived unfairness, job discrimination) and job resources (coworker and supervisor support) on multidimensional sleep health. Two waves of survey data from a subset of full-time workers were obtained from the Midlife in the United States Study approximately 10 years apart. A sleep health composite captured irregularity, dissatisfaction, nap frequency, inefficiency, and suboptimal sleep duration (higher=more sleep health problems). PROCESS Macro evaluated cross-sectional (T1) and sequential (T1 exposureàT1 mediatoràT2 outcome) mediation pathways, adjusting for sociodemographic characteristics, physical health, neuroticism, and work hours. Both cross-sectionally and prospectively, higher negative spillover mediated the association of higher unfairness with more sleep health problems, and the association between higher discrimination and more sleep health problems. There was no support for positive spillover as a mediator between job resources and sleep health cross-sectionally or prospectively. Findings suggest that organizations should reduce the amount of negative spillover by limiting instances of unfairness and discrimination at work to promote specific aspects of employee sleep health such as sleep irregularity, dissatisfaction, efficiency, and nap frequency.
Prevention of diaper rash in newborns and children under 1 year old: results of a clinical study
Authors: Ryumina I. I. , Zakharova N. I. 
Published: August 2024

Introduction. Modern preventive measures of skin diseases aim to maintain the protective skin barrier. The area that comes in direct contact with the diaper becomes excessively wet, the corneous layer is damaged, which results in a weakened barrier function of the epidermis and the occurrence of an inflammatory process, diaper dermatitis.Aim. To study the clinical efficacy and safety of the use of disposable diapers and pull up pants in full-term and premature infants from birth to 1 year of age to prevent diaper dermatitis.Materials and methods. A total of 45 full-term and premature children under 1 year old with various diseases, including skin eruptions in the area covered by the diaper were included in the study. The proposed care products were used for 14 days on the strict condition that they would be reapplied after defecation and during hygiene procedures in a timely manner. The skin status was assessed visually by a paediatrician from Day 1 to 14 of the study using the M. Odio skin assessment scale.Results. The M. Odio scale evaluation of the skin around waist, buttocks, genitals, anal region, and inguinal folds in all children on Days 1, 7 and 14 showed 0 scores. No adverse events were reported during assessment of the skin status over 14 days of the use of care products.Discussion. The observations were consistent with the previously published data demonstrating that maintenance of the functional characteristics of the skin in the area covered by the diaper and exposed to faecal and urinary enzymes, elevated temperature and humidity prevented the development of diaper dermatitis and skin diseases.Conclusion. No signs of diaper dermatitis were detected in all 45 full-term and premature children under 1 year old, including children with various diseases, during 2 weeks of application of disposable Tanoshi Premium diapers and pull up pants in clinical practice. This fact proves the safety and good tolerance of disposable diapers by children under 1 year old provided that the skin care requirements were met. Tanoshi Premium diapers and pull up pants can be recommended for babies of different ages and body weights, including those with diaper dermatitis.
The safety of medicinal prescriptions in children in critical conditions: antibiotics are in focus
Authors: Vlasova A. V. , Kulichenko T. V. , Sychev D. A. 
Published: August 2024

Introduction. The relevance of the introduction of a system for evaluating medicinal prescriptions to control the safety of the use of antibiotics and concomitant therapy is due to the emergence of electronic medical records in multidisciplinary children’s hospitals.Aim. To assess the potential risks of adverse reactions to antibiotics using an implemented retrospective cohort analysis of antimicrobial drug prescriptions in critically ill children.Materials and methods. The analysis of the effect of antibiotic prescriptions on the potential risk of HP in the development of a critical condition in children was performed as part of a prospective observational study at the Morozov Children’s City Clinical Hospital from 02/01/2020 to 09/01/2021 in 100 children aged 0 to 17 years. To evaluate the prescribing lists, a twostage retrospective cohort analysis method was used to assess the potential risks of HP for antibiotics in the development of a critical condition in children with nosocomial infection. The patients were divided into 2 cohorts in 2 stages: at stage 1, an analysis was performed in 1 cohort “outcome HP+” of 30 children with HP on antibiotics and 2 cohort “outcome HP–” of 70 children without HP on antibiotics. At stage 2, an analysis was carried out in the same cohorts with an additional sampling criterion “availability of concomitant therapy” for 40 patients.Results and discussion. The possibilities of taking into account additional potential risks of HP for antibiotics when making an appointment list in children with nosocomial infection with the development of a critical condition are shown. In the group of children receiving concomitant therapy, the highest relative risk of developing HP for antibiotics was revealed when using tigecycline (OR 7.24; 95% CI 0.64–8.21) and meropenem (OR 1.84; 95% CI 1.01–3.36).Conclusion. The study shows the possibilities and prospects for the development of a risk-based approach when choosing combinations of antimicrobial drugs when making an appointment sheet based on an electronic medical record of an inpatient.
Orphan diseases in children: experience in the use of oedematous enteral nutrition
Authors: Tropina E. P. , Zmanovskaya V. A. , Zhivaeva O. N. , Guseva E. N. , Anikina V. S. 
Published: August 2024

Introduction. Increased protein and energy requirements, as well as intoxication symptoms in patients with malignant neoplasms (MN), spinal muscular atrophy (SMA) and cystic fibrosis (CF) determine the need to use specialized protein detoxification nutrition in their diet.Aim. To evaluate the tolerability and clinical efficacy of the domestic specialized food product of dietary therapeutic and dietary preventive nutrition Protein detoxification cocktail NUTRIO (liquid mixture) in children with orphan diseases, over 2 years old. Materials and methods. We observed 18 children with rare diseases, aged from 2 years 11 months to 16 years. 6 children had a confirmed diagnosis of MN, 10 – SMA, 2 – CF. All children received the NUTRIO Detox Protein Cocktail twice a day: children aged 3 to 7 years old – ½ serving (100 ml), and aged 8 to 16 years – 1 serving (200 ml). The observation period was 1 month.Results. It was found that all patients (100% of patients) highly rated the taste of the product. There were no refusals from the product. No allergic, dyspeptic or other side effects were noted during the observation period. All patients showed positive dynamics of nutritional status, an increase in the level of total protein and albumin in the blood, a decrease in markers of intoxication and inflammation, an improvement in the quality of life, increased endurance, physical activity and an improvement in the psycho-emotional background.Discussion. The results we obtained correlate well with the authors’ data on the clinical efficacy, safety and significant economic benefits of using this diet.Conclusions. The use of the domestic specialized food product of dietary therapeutic and dietary preventive nutrition Protein detoxification cocktail NUTRIO in diet therapy of children with malignant neoplasms, SMA and CF is effective for correcting their nutritional status and improving the quality of life.
The impacts of drought on the ecological niches of typical wetland plants in Poyang Lake, China
Authors: Li Xianghu , Lin Yaling , Ye Xuchun , Yuan Canyu , Tan Zhiqiang , Sun Tong 
Published: August 2024

ABSTRACT
Poyang Lake wetland plays an important ecological service function. Frequent drought events have caused significant changes in the distribution pattern of wetland plants. This study analyzed the changes in the distribution elevation of wetland plants in Poyang Lake from 2000 to 2020, including the optimal elevation, and upper and lower limit elevations, and revealed the impacts of drought on the ecological niches of typical wetland plants. The results showed that the wetland plants were distributed in a regular strip pattern according to the elevation gradient. The Polygonum hydropiper–Phalaris arundinacea (PP), Carex cinerascens (Cc), Phragmites australis–Triarrhena lutarioriparia (PT), and Artemisia selengensis (As) communities were mainly distributed at elevations of 8.70–13.62 m, 10.35–14.99 m, 12.00–16.28 m, and 11.82–18.46 m, with optimal elevations of 11.16, 12.67, 14.14, and 15.14 m, respectively. Although the optimal elevations and upper limit elevations of four typical wetland plants exhibited different changing trends, their lower limit elevations showed the significant downward trends, especially for Cc and PP communities. Moreover, drought caused a varying degree of decrease (0.16–0.34 m) in the optimal elevations of four typical wetland plants, the upper and lower limit elevations of most wetland plants had also decreased in dry years.
Coptis Chinensis Franch: Substance Basis, Mechanism of Action and Quality Control Standard Revealed Based on the Q-marker Concept and New Strategy of Systemic Pharmacology and Biosynthesis Research
Authors: Zheng Yating , Zhang Mengyu , Wu Xiaoqing , Tan Rui , Jiang Hezhong 
Published: August 2024

:
Coptis chinensis Franch. (Ranunculaceae, Coptis), a traditional Chinese medicine
(TCM) with thousands of years of clinical use history, also a natural medicine available in many
countries, has wide pharmacological mechanisms and significant bioactivity according to its traditional
efficacy combined with modern scientific research. The quality marker (Q-marker) of C. chinensis
Franch. is predicted in this paper based on the chemical composition and pharmacological
effects of the plant, as well as the current system pharmacology, plant relatedness, biosynthetic
pathways and quantitative analysis of multi-components (QAMS).

:
Natural medicine has the advantage of being multi-component, multi-pathway and multi-target.
However, there are few reports on safety evaluation. This review predicts the Q-marker of C. chinensis,
the safety and efficacy of C. chinensis is provided.

:
Studies from 1975 to 2023 were reviewed from PubMed, Elsevier, ScienceDirect, Web of Science,
SpringerLink, and Google Scholar.

:
Alkaloids and organic acids are the two main component categories of Q-Markers. The specific alkaloids
identified through predictive results include berberine, coptisine, palmatine, epiberberine,
jatrorrhizine, columbamine, and berberrubine. Quinic acid and malic acid, due to their influence
on the content of alkaloids and their ability to aid in identifying the active components of C. chinensis,
are also considered Q-markers.

:
The research strategy of “exploring chemical components, exploring pharmacological activities,
constructing pharmacological mechanism network and locating biosynthetic pathways” was used
to accurately screen the quality markers of C. chinensis in this review and summarise the quality
evaluation methods and criteria. In addition, we updated the biosynthetic pathway of C. chinensis
and refined the specific synthetic pathways of jatrorrhizine (quality markers) and epiberberine
(quality markers). Finally, we summarised the quality evaluation methods of C. chinensis, which
provide an important reference for resource evaluation and provide a key reference for the discovery
of new functional chemical entities for natural medicines.
Evaluation of Thiazolidine Derivatives with Potential Anti-ZIKV Activity
Authors: Calado Gonçalves Sayonara Maria , Vieira Galdino Lília , Costa Lima Morganna , da Silva Moura José Arion , Francisco Viana Douglas Carvalho , da Rosa Michelle Melgarejo , Rebello Ferreira Luiz Felipe Gomes , Zaldini Hernandes Marcelo , Cristiny Pereira Michelly , de Melo Rêgo Moacyr Jesus Barreto , da Rocha Pitta Ivan , de Oliveira França Rafael , da Rocha Pitta Marina Galdino , da Rocha Pitta Maira Galdino 
Published: August 2024

Objective:
In this study, we have synthesized 19 Thiazolidine (TZD) derivatives to investigate
their potential anti-ZIKV effects.

Methods:
Nineteen thiazolidine derivatives were synthesized and evaluated for their cytotoxicity
and antiviral activity against the ZIKA virus.

Results:
Among them, six demonstrated remarkable selectivity against the ZIKV virus, exhibiting
IC50 values of <5μM, and the other compounds did not demonstrate selectivity for the virus. Interestingly,
several derivatives effectively suppressed the replication of ZIKV RNA copies, with derivatives
significantly reducing ZIKV mRNA levels at 24 hours post-infection (hpi). Notably, two
derivatives (ZKC-4 and -9) stood out by demonstrating a protective effect against ZIKV cell entry.
Informed by computational analysis of binding affinity and intermolecular interactions within
the NS5 domain's N-7 and O'2 positions, ZKC-4 and FT-39 displayed the highest predicted affinities.
Intriguingly, ZKC-4 and ZKC-9 derivatives exhibited the most favorable predicted binding
affinities for the ZIKV-E binding site.

Conclusion:
The significance of TZDs as potent antiviral agents is underscored by these findings,
suggesting that exploring TZD derivatives holds promise for advancing antiviral therapeutic strategies.
Copper Electrodes Modified with Gold Nanoparticles Detect Two
Hazardous Contaminants (As, Cd) in Raw Milk
Authors: Das Upama , Daimari Nikhil Kumar , Islam Khairul , Biswas Rajib 
Published: August 2024

Background:
Milk contamination has been a longstanding global concern, with Heavy
Metals (HM) like lead (Pb), mercury (Hg), arsenic (As), and cadmium (Cd) posing significant risks.
These contaminants often infiltrate milk through contaminated water sources or during pasteurization.
This petent introduces a novel approach to detecting milk contaminants by analyzing the current–
voltage (I-V) characteristics of copper (Cu) electrodes modified with gold nanoparticle
(AuNPs).

Methods:
Leveraging the exceptional conductivity of metal nanoparticles, electrons freely traverse
the surface, facilitating electron movement across the copper substrate. Additionally, the nanoparticles
serve as binding agents, aiding in the comparative detection of contaminants. This method enables
the preliminary detection of two HM (As, Cd) by evaluating their current gains in milk supernatant
samples at varying concentrations.

Results:
AuNPs deposited on Cu electrodes exhibited a linear I-V trend, with a significant increase
in current compared to bare electrodes. Spiked milk supernatant drop cast on the electrode system
displayed a current gain, which was evaluated towards sensing application of HM ions in milk. The
synthesized AuNPs underwent initial characterization using a UV-Vis spectrophotometer, revealing
a prominent plasmonic peak around 520 nm, confirming nanoparticle formation. X-Ray Diffraction
(XRD) analysis confirmed the Face-Centred Cubic (FCC) crystal structure.

Conclusion:
Notably, different concentrations (1 and 10 ppm) and types of HM (As, Cd, Hg, and
Pb) in milk supernatant yielded varying current gains, providing insights specifically targeting As
and Cd contamination.