bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Compensation and Work Motivation on Employee Performance in The Personnel Department of The Ministry of Law and Human Rights
Authors: Dolly Dolly Terxy , Christina N. Sihombing  , Poerwaningsih Soekarno  
Published: August 2024

In efforts to improve performance of employees of an organization, there are several ways such as providing proper compensation to employees. A leader must be able to motivate his employees in achieving success at the strategic goals of employee performance. Compensation is very important so that it can have a positive impact on employees in order to increase their motivation at work and improve their overall performance. The purposes of these studies are to finding out how compensation and motivations affect employee performance, and how it impacts the performance of the Personnel Agency of Ministry of Law and Human Right as the object of these research. In this study, the population sample consisted of 50 employees. These research use a quantitative approach that is descriptives in natured. To investigate the difference between work compensation and employee motivation, an analysis was carried out using primary data which was collected through observation, interviews, and distributing questionnaires. The analyst was perform using the Statistically Products and Services Solution (SPSS) software version 26. The data analyst technique in these studies use multipled linear regressions. The result of the studies show that compensation and motivations have a positive and significancy effects on employee performances either partial or simultaneous. Based on results of simultaneous influence hypothesis, compensations and motivations on employee performances obtained a coefficient of determination of 66.1%, and other variables that are influenced by 33.9%. So, it can be concluding that compensations and motivations affecting employee performances at the Personnel Agency of Ministry of Law and Human Right.
Keywords: Compensation, Work Motivation, Employee Performance
KUALITAS PELAYANAN ADMINISTRASI KEPENDUDUKAN DI DINAS KEPENDUDUKAN DAN CATATAN SIPSIL KOTA BANDUNG DI MASA PANDEMI COVID-19
Authors: Putri Lusy Riadina 
Published: August 2024

Pelayanan merupakan salah satu tugas dan fungsi dari profesi Aparatur Sipil Negara (ASN), sebagai abdi negara dan abdi masyarakat ASN memiliki beberapa tugas pokok dan fungsi, salah satunya yakni pelayanan publik. Sejak awal tahun 2021 tepatnya pada bulan Maret Indonesia mulai memasuki fase waspada terhadap pandemi Coronavirus Disease (COVID-19) sehingga menyebabkan perubahan besar-besaran pada seluruh segmen kehidupan. Kota Bandung merupakan Ibu Kota Provinsi Jawa Barat yang tidak luput dari dampak penularan Covid-19, tentunya hal ini menimbulkan perubahan dalam pola interaksi sosial warga masyarakatnya. Dimasa Pandemi Covid-19 sektor Pelayanan Publik utamanya dalam kepengurusan Administrasi Kependudukan di Dinas Kependudukan dan Catatan Sipil Kota Bandung juga mengalami beberapa perubahan yang awalnya melakukan pelayanan langsung (Offline) sekarang dengan adanya dampak Pademi Covid-19 ini tidak sedikit yang kemudian melakukan pelayanan secara tidak langsung atau via daring (Online). Metode penelitian yang digunakan oleh penulis yakni jenis penelitian deskriptif dengan pendekatan kualitatif. Analisis data yang digunakan dalam penelitian ini yaitu Analisis Data Model Miles dan Huberman. Kesimpulan dalam penelitian ini dapat dilihat dari lima dimensi yang penulis gunakan untuk mengukur kualitas pelayanan Administrasi Kependudukan, yaitu dari hasil rata-rata persentase kelima dimensi kualitas jasa menurut Parasuraman et al., (1988), dapat dikatakan bahwa kualitas pelayanan di Dinas Kependudukan dan Catatan Sipil Kota Bandung bekualitas. Meskipun pada dimensi Tangibles (kenampakan fisik) dan Responsiveness (daya tanggap) masih terdapat respon negatif dari masyarakat. Namun tiga dimensi lainnya, yaitu Reability (kehandalan), Assurance (jaminan) dan Emphaty (empati) mendapat respon yang positif dari masyarakat.
PERAN BADAN USAHA MILIK DESA (BUMDes) DALAM MENDUKUNG PENGENTASAN KEMISKINAN DESA
Authors: Mulianingsih Sunasih 
Published: August 2024

BUMDes sebagai kelembaga ekonomi desa, memiliki peran yang sangat strategis didalam menanggulangi kemiskinan di Desa karena BUMDes didirikan salah satu tugasnya untuk dapat mengentasan kemiskinan. Realita yang ada bahwa sebagian desa-desa di Indonesia sebagian besar belum memiliki keberdayaan dan tergolong masyarakat yang tidak mampu dan tergolong miskin. Desa memiliki keberdayaan untuk melakukan pemberdayaan masyarakat, membangun insfrastruktur dan pelayanan kepada masyarakat desa, serta mengatasi kemiskinan yang berada di desa. Tujuannya adalah untuk pengentasan kemiskinan dapat segera diminimalisir angka kemiskinannya dapat ditekan sekecil mungkin. Peneliti tertarik membuat tulisan ilmiah tentang Peran BUMDes dalam Pengentasan Kemiskinan di Desa menggunakan kualitatif diskriptif dan data diperoleh dari kajian-kajian pustaka, kajian kajian ilmiah, dan dokumentasi serta peraturan perundang-undangan yang berlaku. Hasil simpulan bahwa keberadaan BUMDes jika dikelola dengan baik dan profesional, dengan melalui pemberdayaaan, diajak masyarakat untuk berpartisipasi menjadi para usaha-usahawan desa yang menghasilkan produk-produk yang dapat dipasarkan bekerjasama dengan BUMDes masyarakat akan berdaya dan memiliki kemampuan sehingga mereka dapat memenuhi kebutuhan dasarnya dan terbebas dari belenggu kemiskinan yang selama ini mereka sandang.
Kata Kunci: Peran; Bumdes; Pengentasan Kemiskinan.
Adjusting to errors in arithmetic: a longitudinal investigation of metacognitive control in 7–9-year-olds
Authors: Jacobs Eveline , Bellon Elien , De Smedt Bert 
Published: August 2024

IntroductionMonitoring and controlling one's performance are essential skills for children's cognitive development and academic success. Metacognitive control, operationalized as post-error adjustments, is, however, often measured in conflict tasks, but the findings of such studies may not be readily generalizable to academic domains, such as arithmetic. Yet, investigating how children control their performance in arithmetic is crucial in understanding the large individual differences within this specific academic domain. This longitudinal study investigated how children control their performance through post-error slowing and accuracy improvement in arithmetic. We additionally examined this development of metacognitive control in a working memory task, to further unravel its domain-generality or the lack thereof.MethodsA cohort of 127 typically developing children, followed up longitudinally from 7–8 years old (2nd grade of primary school) to 8–9 years old (3rd grade of primary school), completed an arithmetic and working memory task at two time points.Results and discussionMeticulous comparison of response times and accuracy rates following errors with those following correct answers revealed the presence of metacognitive control at each time point. We observed significant positive correlations between children's metacognitive control and their arithmetic accuracy at 7–8 years old, underscoring a possible adaptive role of metacognitive control in the learning phase of arithmetic. No correlations were found between the post-error adjustments in the arithmetic task and those in the working memory task, challenging previous evidence for domain-generality of post-error adjustments.
Medical comorbidities and other factors associated with migraine among individuals with diabetes mellitus in Hungary: a cross-sectional study using European Health Interview Surveys 2009–2019
Authors: Varga Eszter , Ghanem Amr Sayed , Faludi Eszter , Nguyen Chau Minh , Kovács Nóra , Nagy Attila Csaba 
Published: August 2024

IntroductionMigraine, a debilitating neurological disorder characterized by recurrent headaches, affects over 1.1 billion individuals globally. Diabetes mellitus (DM), a chronic metabolic condition marked by high blood sugar levels, affects 463 million individuals according to the International Diabetes Federation. Our study aimed to evaluate the association between migraine and DM and to identify several demographic, socioeconomic, and lifestyle factors, as well as medical and psychiatric comorbidities, associated with migraine among individuals with DM.MethodsThis cross-sectional study is based on data from the European Health Interview Surveys conducted in 2009, 2014, and 2019 in Hungary. Pearson’s chi-squared tests and multiple logistic regression models were used to assess associations. Statistical significance was set at p&lt;0.05.ResultsIn multiple regression analyses, we found no significant association between DM and migraine after adjusting for socioeconomic status, various health conditions, and lifestyle factors (OR=0.84, 95% CI: 0.66-1.06). However, adults with DM who had comorbid conditions including stroke (OR=2.08, 95% CI: 1.06-4.08), low back pain (OR=3.52, 95% CI: 2.13-5.84), and depression (OR=4.91, 95% CI: 2.84-8.47) were significantly more likely to suffer from migraine.DiscussionOur study found no significant difference in the prevalence of migraine among adults with and without diabetes mellitus. However, several comorbidities were found to be significantly associated with migraine occurrence in those with DM. Thus, the study’s results highlight the need for proper management of diabetes, especially in terms of comorbidities, to mitigate migraine risk factors and improve patient outcomes.
Plasma level of alpha-synuclein oligomers as a biomarker for isolated rapid eye movement sleep behavior disorder diagnosis and progression: a prospective cohort study
Authors: Ying Chao , Zhang Hui , Wang Ting , Li Yuan , Mao Wei , Hu Songnian , Zhao Lifang , Cai Yanning 
Published: August 2024

BackgroundAlpha-synuclein oligomers (o-α-syn) are pivotal in the pathogenesis of α-synucleinopathy. Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) serves as an early indicator of the disease, offering insights into disease mechanisms and early intervention. Nevertheless, the diagnostic and predictive potential of o-α-syn in iRBD remains largely unexplored. This study aimed to evaluate the plasma levels of o-α-syn in patients and investigate their utility as biomarkers for diagnosis of and predicting phenoconversion in iRBD.MethodsA total of 143 participants, including 77 polysomnography-confirmed iRBD patients and 66 normal controls (NC), were recruited for this longitudinal observational study. Baseline clinical assessments and plasma collection were conducted for all iRBD patients, with 72 of them undergoing regularly prospective follow-up assessments for parkinsonism or dementia. Plasma levels of o-α-syn were quantified using enzyme-linked immunosorbent assay, and were compared between groups using a general linear model adjusted for age and sex. The diagnostic performance of plasma o-α-syn in iRBD was evaluated by area under the receiver operating characteristic curve (AUC) with 95% CI. Cox regression analysis and Kaplan–Meier survival curves were employed to assess the predictive value of plasma o-α-syn for phenoconversion in iRBD.ResultsPlasma o-α-syn levels did not exhibit statistically significant differences among iRBD converter patients, iRBD nonconverter patients, and NC. The AUC for distinguishing NC from iRBD was 0.52 (95% CI: 0.42–0.62, p = 0.682). Spearman correlation analysis revealed a significant positive correlation between plasma o-α-syn levels and MOCA scores in the iRBD group (p &lt; 0.001). Subgroup analyses indicated that iRBD patients with cognitive decline (p = 0.058) and depressive symptoms (p = 0.017) had notably lower o-α-syn levels compared to those without such symptoms. Over a median follow-up period of 5.83 years, 26 iRBD patients developed neurodegenerative synucleinopathies. Cox regression and Kaplan–Meier survival curve analyses indicated that plasma level of o-α-syn lacked a predictive value for disease conversion in iRBD patients.ConclusionDespite a potential role in the pathophysiology of iRBD, o-α-syn are not appropriate biomarkers for diagnosing or predicting disease progression. While this study offers insights into the pathogenesis of iRBD and neurodegenerative synucleinopathies, further large-scale longitudinal studies are warranted to validate these findings.
Influence of an inspiratory muscle fatigue protocol on healthy youths on respiratory muscle strength and heart rate variability. A randomized controlled trial
Authors: Ladriñán-Maestro Arturo , Sánchez-Infante Jorge , Martín-Vera Daniel , Sánchez-Sierra Alberto 
Published: August 2024

Introduction: Inspiratory muscle fatigue has been shown to have effects on the autonomic nervous system and physical condition. This study aimed to evaluate the influence of an inspiratory muscle fatigue protocol on respiratory muscle strength and heart rate variability in healthy youths.Materials and Methods: A randomized controlled clinical trial, employing double-blinding, was conducted with twenty-seven participants aged 18–45 years, non-smokers and engaged in sports activity at least three times a week for a minimum of 1 year. Participants were randomly assigned to three groups: Inspiratory Muscle Fatigue group, Activation group, and Control group. Measurements of heart rate variability, diaphragmatic ultrasound, and maximum inspiratory pressure were taken at two stages: before the intervention and immediately after treatment.Results: In our results with respect to baseline to post-treatment, the inspiratory muscle fatigue group showed lower values in the Sniff contraction velocity variable (10.96 cm/s ± 1.99–8.34 cm/s ± 1.23; p &lt; 0.01) and higher values in the activation group (10.59 cm/s ± 0.89–12.66 cm/s ± 1.15; p &lt; 0.01) with respect to the control group (10.27 cm/s ± 1.48–9.97 cm/s ± 1.42). On the other hand, the inspiratory muscle fatigue group showed higher values in the Low frequency variable (49.37 n.u. ± 13.91 to 69.48 n.u. ± 8.22; p &lt; 0.01) and lower values in the activation group (57.92 n.u. ± 8.37 to 41.59 n.u. ± 11.21; p &lt; 0.01) with respect to the control group (50.83 n.u. ± 17.30 to 52.10 n.u. ± 20.64). Additionally, significant correlations were found between respiratory variables and heart rate variability variables.Conclusion: Acute fatigue of the inspiratory musculature appears to negatively impact heart rate variability and inspiratory muscle strength in healthy youths.Clinical Trial Registration:https://clinicaltrials.gov/study/NCT06278714; Identifier: NCT06278714.
A pilot study of a new app based on self-compassion for the prevention and promotion of mental health among Brazilian college students
Authors: Schaab Bruno Luis , Cunha Lara Finkler , Silveira Desiree Cordoni , da Silva Pamela Carvalho , Ballejos Kellen Greff , Diaz Gabriela Bertoletti , Kaiser Vanessa , Calvetti Prisla Ücker , Cazella Sílvio César , Barros Helena Maria Tannhauser , Reppold Caroline Tozzi 
Published: August 2024

IntroductionEpidemiological data suggest substantial issues on the mental health of university students worldwide. Self-compassion is associated with lower rates of psychological distress and better positive mental health. Thus, we have developed a app-based intervention based on self-compassion principles targeting the prevention and promotion of mental health in college students. The current pilot study assessed adherence to intervention, preliminary mental health benefits, and satisfaction and acceptability with the app among Brazilian college students.MethodsThe study employed a pre-experimental single-group design along with pre-test and post-test assessments (n = 23). A mixed methods approach was utilized to comprehensively assess the outcomes of the intervention.ResultsThe overall adherence rate for the intervention was 37.87%, with 26.26% of participants successfully completing all modules. Among the 21 outcomes assessed, 15 exhibited statistically significant results. Notably, there was a substantial increase in self-compassion, demonstrating a large effect size (d = 1.15), and a moderate effect size reduction in stress (d = 0.62) and anxiety (d = 0.52). All satisfaction indicators for the intervention received scores above 7. The intervention was well-received by participants who completed it, although a potential barrier identified was the volume of text within the app and the need to adopt a more playful and concise format for the intervention.DiscussionDespite a notable participant dropout, the adherence to intervention aligns with patterns observed in other online interventions conducted in real-world settings. The observed mental health benefits, high satisfaction levels, and positive acceptance underscore the rationale for pursuing a subsequent randomized clinical trial.
POP1 Facilitates Proliferation in Triple-Negative Breast Cancer via m6A-Dependent Degradation of CDKN1A mRNA
Authors: Zhang Chao , Wang Sifen , Lu Xiuqing , Zhong Wenjing , Tang Yunyun , Huang Weiling , Wu Fengjia , Wang Xiumei , Wei Weidong , Tang Hailin 
Published: August 2024

Triple-negative breast cancer (TNBC) is currently the worst prognostic subtype of breast cancer, and there is no effective treatment other than chemotherapy. Processing of precursors 1 (POP1) is the most substantially up-regulated RNA-binding protein (RBP) in TNBC. However, the role of POP1 in TNBC remains clarified. A series of molecular biological experiments in vitro and in vivo and clinical correlation analyses were conducted to clarify the biological function and regulatory mechanism of POP1 in TNBC. Here, we identified that POP1 is significantly up-regulated in TNBC and associated with poor prognosis. We further demonstrate that POP1 promotes the cell cycle and proliferation of TNBC in vitro and vivo. Mechanistically, POP1 directly binds to the coding sequence (CDS) region of CDKN1A mRNA and degrades it. The degradation process depends on the N6-methyladenosine (m6A) modification at the 497th site of CDKN1A and the recognition of this modification by YTH N6-methyladenosine RNA binding protein 2 (YTHDF2). Moreover, the m6A inhibitor STM2457 potently impaired the proliferation of POP1-overexpressed TNBC cells and improved the sensitivity to paclitaxel. In summary, our findings reveal the pivotal role of POP1 in promoting TNBC proliferation by degrading the mRNA of CDKN1A and that inhibition of m6A with STM2457 is a promising therapeutic strategy for TNBC.
Inhibition of ALOX12–12-HETE Alleviates Lung Ischemia–Reperfusion Injury by Reducing Endothelial Ferroptosis-Mediated Neutrophil Extracellular Trap Formation
Authors: Li Chongwu , Gao Peigen , Zhuang Fenghui , Wang Tao , Wang Zeyu , Wu Guodong , Zhou Ziheng , Xie Huikang , Xie Dong , Zhao Deping , Wu Junqi , Chen Chang 
Published: August 2024

Lung ischemia–reperfusion injury (IRI) stands as the primary culprit behind primary graft dysfunction (PGD) after lung transplantation, yet viable therapeutic options are lacking. In the present study, we used a murine hilar clamp (1 h) and reperfusion (3 h) model to study IRI. The left lung tissues were harvested for metabolomics, transcriptomics, and single-cell RNA sequencing. Metabolomics of plasma from human lung transplantation recipients was also performed. Lung histology, pulmonary function, pulmonary edema, and survival analysis were measured in mice. Integrative analysis of metabolomics and transcriptomics revealed a marked up-regulation of arachidonate 12-lipoxygenase (ALOX12) and its metabolite 12-hydroxyeicosatetraenoic acid (12-HETE), which played a pivotal role in promoting ferroptosis and neutrophil extracellular trap (NET) formation during lung IRI. Additionally, single-cell RNA sequencing revealed that ferroptosis predominantly occurred in pulmonary endothelial cells. Importantly,
Alox12
-knockout (KO) mice exhibited a notable decrease in ferroptosis, NET formation, and tissue injury. To investigate the interplay between endothelial ferroptosis and NET formation, a hypoxia/reoxygenation (HR) cell model using 2 human endothelial cell lines was established. By incubating conditioned medium from HR cell model with neutrophils, we found that the liberation of high mobility group box 1 (HMGB1) from endothelial cells undergoing ferroptosis facilitated the formation of NETs by activating the TLR4/MYD88 pathway. Last, the administration of ML355, a targeted inhibitor of Alox12, mitigated lung IRI in both murine hilar clamp/reperfusion and rat left lung transplant models. Collectively, our study indicates ALOX12 as a promising therapeutic strategy for lung IRI.
Comparative characteristics of endovascular occlusion and thoracoscopic amputation of left atrial appendage in patients with atrial fibrillation
Authors: Khalimov Z. Z. , Mamchur S. E. , Mamchur I. N. , Kozyrin K. A. , Bohan N. S. , Sizova I. N. 
Published: August 2024

Aim. To compare the effectiveness and safety of endovascular occlusion and thoracoscopic amputation of the left atrial appendage (LAA) in patients with atrial fibrillation (AF).Methods. We present a retrospective single-center study with a prospective component including 25 patients with AF who underwent thoracoscopic amputation of the LAA and 31 patients on prospective part who underwent endovascular occlusion of the LAA. All patients signed voluntary informed consent for medical intervention and participation in the study. The criteria for selecting patients for thoracoscopic amputation of the LAA were the impossibility of performing an endovascular technique, features of its anatomy and increased trabecularity.Results. In the group of patients with thoracoscopic amputation of the LAA, 2 cases of embologenic stump of the LAA with a depth of 1.6 cm (8%) were identified; these patients were recommended to continue taking anticoagulant therapy. Among patients who underwent thoracoscopic amputation, no complications were identified in the first 30 days after surgery, including mortality, bleeding, phrenic nerve paresis, acute cerebrovascular accident, pleurisy, pneumothorax, hemothorax. In 3 patients who underwent endovascular occlusion of the LAA, hematomas were detected at the site of puncture of the great vessels (9.7%), in 2 patients thrombus were detected on the occlusion device according to the results of transesophageal echocardiography (6.5%), which required the prescription of warfarin in these patients. Also, in 2 patients (6.5%) during implantation of the occluder into the LAA, as a result of the incorrect diameter of the disk of the occluding device, a residual cavity with a depth of 0.7 cm was formed between the ridge and the occluder. No significant differences in the frequency of non-severe complications were found in the groups, p =0.139. During the year of postoperative observation, thromboembolic complications were absent in the operated patients of both groups.Conclusion. When comparing two methods of LAA isolation, no severe complications were identified, either in the perioperative or in the early or late postoperative period. There were no significant differences in the incidence of non-severe complications in the early postoperative period. Thus, the effectiveness and safety of thoracoscopic amputation and endovascular occlusion of the left atrial appendage are comparable.