bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Zirconium Nitride Formation Under Zirconium-Based Claddings Oxidation in Air During NPP Beyond-Design-Basis Accidents
Authors: Vasiliev Alexander 
Published: November 2014

The high-temperature (≈800–2100°K) oxidation of nuclear reactor fuel assembly zirconium-based claddings in the air behaves in different way compared to oxidation in the steam.
First, the heat effect of the chemical reaction of oxidation in the air is approximately two times larger than in the steam.
Second, the kinetics of oxidation in the air is non-parabolic (approximately linear, that is more strong) in contrast to parabolic kinetics of oxidation in the steam.
Third, important factor is the diffusion of oxygen and nitrogen atoms through very porous (transparent) nitride layers formed in α-Zr(O) layer. It resulted in linear kinetics in small-scale tests and strong hydrogen release during reflood phase in QUENCH-16 and PARAMETER-SF4 tests. The role of nitride formation during air ingress phase seems to be extremely important especially if oxygen starvation phase is present.
Fourth, it is necessary to treat adequately the interdiffusion of oxygen and nitrogen in gas mixture containing, oxygen, nitrogen and possibly steam, hydrogen, other non-condensables. This effect influences the time moment of oxygen starvation.
Fifth, it is important to take into account the heat effect of nitridation (formation of ZrN) which is not small.
Sixth, at final phase (quenching at water reflood or slow cooling) the reoxidation of nitrides can take place. During this process. nitrogen and hydrogen (in steam atmosphere) is released and additional chemical heat generation is produced.
The development of a special model of Zr-based alloys oxidation in air considering all above-mentioned processes is currently underway, some results are presented below. A numerical scheme is realized to determine layer boundaries relocation and layer transformations in claddings.
The model is implemented to SOCRAT computer modeling code. This model is being verified on separate-effect tests as well as on integral air ingress experiments QUENCH-10, QUENCH-16 and PARAMETER-SF4.
Pacui Virus, Rio Preto da Eva Virus, and Tapirape Virus, Three Distinct Viruses within the Family
Bunyaviridae
Authors: Rodrigues Daniela Sueli Guerreiro , Medeiros Daniele Barbosa de Almeida , Rodrigues Sueli Guerreiro , Martins Livia Caricio , de Lima Clayton Pereira Silva , de Oliveira Layanna Freitas , de Vasconcelos Janaina Mota , Da Silva Daisy Elaine , Cardoso Jedson Ferreira , da Silva Sandro Patroca , Vianez-Júnior João Lídio da Silva Gonçalves , Nunes Márcio Roberto Teixeira , Vasconcelos Pedro Fernando da Costa 
Published: November 2014

ABSTRACT

Nearly complete genome sequences for three ungrouped viruses, Pacui virus (BEAN27326), Rio Preto da Eva virus (BEAR540870), and Tapirape virus (BEAN767592) isolated in the Amazon region are reported here. All three genomic segments (small, medium and large RNA) were recovered and were similar to members of the genus
Orthobunyavirus
.
Draft Genome Sequence of Bacillus megaterium Type Strain ATCC 14581
Authors: Arya Gitanjali , Petronella Nicholas , Crosthwait Jennifer , Carrillo Catherine D. , Shwed Philip S. 
Published: November 2014

ABSTRACT

Bacillus megaterium
is a Gram-positive, rod-shaped, spore-forming bacterium of biotechnological importance. Here, we report a 5.7-Mbp draft genome sequence of
B. megaterium
ATCC 14581, which is the type strain of the species.
Exploring the Genome of Cheese Starter Lactic Acid Bacterium Lactococcus lactis subsp.
lactis
CECT 4433
Authors: Tschoeke Diogo Antonio , Moreira Ana Paula B. , Chimetto Tonon Luciane A. , de Mesquita Milene Miranda A. , Gregoracci Gustavo B. , Gomez-Gil Bruno , Valle Rogério , Thompson Cristiane C. , Thompson Fabiano L. 
Published: November 2014

ABSTRACT

Here, we present the draft genome sequences of
Lactococcus lactis
subsp.
lactis
CECT 4433, a cheese fermentation starter strain. The genome provides further insight into the genomic plasticity, biocomplexity (including gene strain specifics), and evolution of these genera.
Draft Genome Sequences of Marine Flavobacterium Algibacter lectus Strains SS8 and NR4
Authors: Takatani Naoki , Nakanishi Masato , Meirelles Pedro , Mino Sayaka , Suda Wataru , Oshima Kenshiro , Hattori Masahira , Ohkuma Moriya , Hosokawa Masashi , Miyashita Kazuo , Thompson Fabiano L. , Niwa Ako , Sawabe Toko , Sawabe Tomoo 
Published: November 2014

ABSTRACT

Here, we present the draft genome sequences of a zeaxanthin-producing flavobacterium,
Algibacter lectus
strains SS8 and NR4, isolated from coastal sediment and rock surfaces in Hakodate, Japan, respectively. This genomic information represents the first
Algibacter
genome sequences, which will help us to elucidate the biology and evolution of
Flavobacteriaceae
bacteria.
Draft Genome Sequence of Bacillus alcalophilus AV1934, a Classic Alkaliphile Isolated from Human Feces in 1934
Authors: Attie Oliver , Jayaprakash Anitha , Shah Hardik , Paulsen Ian T. , Morino Masato , Takahashi Yuka , Narumi Issay , Sachidanandam Ravi , Satoh Katsuya , Ito Masahiro , Krulwich Terry A. 
Published: November 2014

ABSTRACT

Bacillus alcalophilus
AV1934, isolated from human feces, was described in 1934 before microbiome studies and recent indications of novel potassium ion coupling to motility in this extremophile. Here, we report draft sequences that will facilitate an examination of whether that coupling is part of a larger cycle of potassium ion-coupled transporters.
Genome Sequences of
Lactobacillus
sp. Strains wkB8 and wkB10, Members of the Firm-5 Clade, from Honey Bee Guts
Authors: Kwong Waldan K. , Mancenido Amanda L. , Moran Nancy A. 
Published: November 2014

ABSTRACT

We sequenced two strains from the
Lactobacillus
Firm-5 clade, a dominant group of symbionts in the guts of honey bees and other social bees. The genome of strain wkB8, comprising a 1.93-Mb chromosome and a 6.4-kb plasmid, was fully closed, while strain wkB10 was assembled into 32 contigs. These genomes will provide insights into how gut symbionts evolve and interact with their host species.
Complete Genome Sequence of the Multiresistant Acinetobacter baumannii Strain AbH12O-A2, Isolated during a Large Outbreak in Spain
Authors: Merino M. , Alvarez-Fraga L. , Gómez M. J. , Aransay A. M. , Lavín J. L. , Chaves F. , Bou G. , Poza M. 
Published: November 2014

ABSTRACT

We report the complete genome sequence of
Acinetobacter baumannii
strain AbH12O-A2, isolated during a large outbreak in Spain. The genome has 3,875,775 bp and 3,526 coding sequences, with 39.4% G+C content. The availability of this genome will facilitate the study of the pathogenicity of the
Acinetobacter
species.
The Draft Genome Sequence of
Sphingomonas
sp. Strain FukuSWIS1, Obtained from Acidic Lake Grosse Fuchskuhle, Indicates Photoheterotrophy and a Potential for Humic Matter Degradation
Authors: Salka Ivette , Srivastava Abhishek , Allgaier Martin , Grossart Hans-Peter 
Published: November 2014

ABSTRACT

Sphingomonas
spp. are
Alphaproteobacteria
considered to be versatile bacteria that can utilize a variety of natural substrates available in terrestrial and aquatic systems.
Sphingomonas
sp
.
strain FukuSWIS1 was isolated from the eutrophic and acidic freshwater Lake Grosse Fuchskuhle in northeastern Germany. The strain has a genome size of 3.89 Mb, possesses a set of photosynthetic genes, and expresses photopigment BChl
a
under oxic conditions. Thus, this strain belongs to the aerobic anoxygenic phototrophic (AAP) bacteria, which are most likely involved in humic matter degradation as indicated by the presence of organic compound mineralizing genes.
High-Quality Draft Genome Sequence of
Babesia divergens
, the Etiological Agent of Cattle and Human Babesiosis
Authors: Cuesta Isabel , González Luis M. , Estrada Karel , Grande Ricardo , Zaballos Ángel , Lobo Cheryl A. , Barrera Jorge , Sanchez-Flores Alejandro , Montero Estrella 
Published: November 2014

ABSTRACT

Babesia divergens
causes significant morbidity and mortality in cattle and splenectomized or immunocompromised individuals. Here, we present a 10.7-Mb high-quality draft genome of this parasite close to chromosome resolution that will enable comparative genome analyses and synteny studies among related parasites.
Draft Genome Sequence of
Bacillus
sp. Strain BSC154, Isolated from Biological Soil Crust of Moab, Utah
Authors: Bailey Alexis C. , Kellom Matthew , Poret-Peterson Amisha T. , Noonan Kathryn , Hartnett Hilairy E. , Raymond Jason 
Published: November 2014

ABSTRACT

Bacillus
sp. BSC154 was isolated from a biological soil crust near Moab, Utah. The strain appears to be capable of chemotaxis and biofilm production. The BSC154 genome contains iron siderophore production, nitrate reduction, mixed acid-butanediol fermentation, and assimilatory and dissimilatory sulfate metabolism pathways.
Can the painDETECT Questionnaire score and MRI help predict treatment outcome in rheumatoid arthritis: protocol for the Frederiksberg hospital's Rheumatoid Arthritis, pain assessment and Medical Evaluation (FRAME-cohort) study
Authors: Rifbjerg-Madsen Signe , Christensen Anton Wulf , Boesen Mikael , Christensen Robin , Danneskiold-Samsøe Bente , Bliddal Henning , Bartels Else Marie , Locht Henning , Amris Kirstine 
Published: November 2014

IntroductionPain in rheumatoid arthritis (RA) is traditionally considered to be of inflammatory origin. Despite better control of inflammation, some patients still report pain as a significant concern, even when being in clinical remission. This suggests that RA may prompt central sensitisation—one aspect of chronic pain. In contrast, other patients report good treatment response, although imaging shows signs of inflammation, which could indicate a possible enhancement of descending pain inhibitory mechanisms.When assessing disease activity in patients with central sensitisation, the commonly used disease activity scores (eg, DAS28-CRP (C reactive protein)) will yield constant high total scores due to high tender joint count and global health assessments, whereas MRI provides an isolated estimate of inflammation.The objective of this study is, in patients with RA initiating anti-inflammatory treatment, to explore the prognostic value of a screening questionnaire for central sensitisation, hand inflammation assessed by conventional MRI, and the interaction between them regarding treatment outcome evaluated by clinical status (DAS28-CRP). For the purpose of further exploratory analyses, dynamic contrast-enhanced MRI (DCE-MRI) is performed.Method and analysisThe painDETECT Questionnaire (PDQ), originally developed to screen for a neuropathic pain component, is applied to indicate the presence of central sensitisation. Adults diagnosed with RA are included when either (A) initiating disease-modifying antirheumatic drug treatment, or (B) initiating or switching to biological therapy.We anticipate that 100 patients will be enrolled, tested and reassessed after 4 months of treatment.Data collection includesClinical data, conventional MRI, DCE-MRI, blood samples and patient-reported outcomes.Ethics and disseminationThis study aims at supporting rheumatologists to define strategies to reach optimal treatment outcomes in patients with RA based on chronic pain prognostics. The study has been approved by The Capital region of Denmark's Ethics Committee; identification number H-3-2013-049. The results will be published in international peer-reviewed journals.
Better-than-average and worse-than-average hospitals may not significantly differ from average hospitals: an analysis of Medicare Hospital Compare ratings
Authors: Paddock Susan M , Adams John L , Hoces de la Guardia Fernando 
Published: November 2014

BackgroundPublic report card designers aim to provide comprehensible provider performance information to consumers. Report cards often display classifications of providers into performance tiers that reflect whether performance is statistically significantly above or below average or not statistically significantly different from average. To further enhance the salience of public reporting to consumers, report card websites often allow a user to compare a subset of selected providers on tiered performance rather than direct statistical comparisons of the providers in a consumer's personal choice set.ObjectiveWe illustrate the differences in conclusions drawn about relative provider performance using tiers versus conducing statistical tests to assess performance differences.MethodsUsing publicly available cross-sectional data from Medicare Hospital Compare on three mortality and three readmission outcome measures, we compared each provider in the top or bottom performance tier with those in the middle tier and assessed the proportion of such comparisons that exhibited no statistically significant differences.ResultsAcross the six outcomes, 1.3–6.1% of hospitals were classified in the top tier. Each top-tier hospital did not statistically significantly differ in performance from at least one mid-tier hospital. The percentages of mid-tier hospitals that were not statistically significantly different from a given top-tier hospital were 74.3–81.1%. The percentages of hospitals classified as bottom tier were 0.6–4.0%. Each bottom-tier hospital showed no statistically significant difference from at least one mid-tier hospital. The percentage of mid-tier hospitals that were not significantly different from a bottom-tier hospital ranged from 60.4% to 74.8%.ConclusionsOur analyses illustrate the need for further innovations in the design of public report cards to enhance their salience for consumers.
Volatiles in subduction zone magmatism
Authors: Zellmer Georg F. , Edmonds Marie , Straub Susanne M. 
Published: November 2014

Abstract
The volatile cycle at subduction zones is key to the petrogenesis, transport, storage and eruption of arc magmas. Volatiles control the flux of slab components into the mantle wedge, are responsible for melt generation through lowering the solidi of mantle materials, and influence the crystallizing phase assemblages in the overriding crust. Globally, magma ponding depths may be partially controlled by melt volatile contents. Volatiles also affect the rate and extent of degassing during magma storage and decompression, influence magma rheology and therefore control eruption style. The style of eruptions in turn determines the injection height of environmentally sensitive gases into the atmosphere and the impact of explosive arc volcanism. In this overview we summarize recent advances regarding the role of volatiles during slab dehydration, melt generation in the mantle wedge, magmatic evolution in the overriding crust, eruption triggering, and the release of some magmatic volatiles from volcanic edifices into the Earth's atmosphere.
Rediscovering geoheritage, reinventing geotourism: 200 years of experience from the Sudetes, Central Europe
Authors: Migoń Piotr 
Published: November 2014

Abstract
The Sudetes is a mountain range in Central Europe and an area of remarkable geodiversity. In recent years, the area has been promoted as a geotourist destination and various initiatives aimed at better understanding geoheritage have been implemented. An interest in scenic landscapes is not new however, and dates back to the end of the eighteenth century. Two areas within the Sudetes are cradles of local nature-based tourism. These are the granite massif of the Karkonosze in the west and the sandstone stepped plateau of Broumov Highland and Stołowe Mountains in the central part of the Sudetes. In both, physical access to the key geosites was provided as early as in the nineteenth century, while an interpretation component was added in the early twentieth century. A side-effect of political change following the end of World War II was the neglect and dilapidation of many sites, as well as the disappearance of geoheritage appreciation from the collective social memory. In the last decade many of those early achievements were rediscovered and provided the foundations for contemporary activities. An educational component based on modern science is now included in the features which were discovered as tourist attractions long ago.
Folate Pathway Gene Polymorphisms, Maternal Folic Acid Use, and Risk of Childhood Acute Lymphoblastic Leukemia
Authors: Milne Elizabeth , Greenop Kathryn R. , Scott Rodney J. , Haber Michelle , Norris Murray D. , Attia John , Jamieson Sarra E. , Miller Margaret , Bower Carol , Bailey Helen D. , Dawson Somer , McCowage Geoffrey B. , de Klerk Nicholas H. , van Bockxmeer Frank M. , Armstrong Bruce K. 
Published: November 2014

AbstractBackground: Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukemia (ALL). We investigated associations between ALL risk and folate pathway gene polymorphisms, and their modification by maternal folic acid supplements, in a population-based case–control study (2003–2007).Methods: All Australian pediatric oncology centers provided cases; controls were recruited by national random digit dialing. Data from 392 cases and 535 controls were included. Seven folate pathway gene polymorphisms (MTHFR 677C&gt;T, MTHFR 1298A&gt;C, MTRR 66A&gt;G, MTR 2756 A&gt;G, MTR 5049 C&gt;A, CBS 844 Ins68, and CBS 2199 T&gt;C) were genotyped in children and their parents. Information on prepregnancy maternal folic acid supplement use was collected. ORs were estimated with unconditional logistic regression adjusted for frequency-matched variables and potential confounders. Case–parent trios were also analyzed.Results: There was some evidence of a reduced risk of ALL among children who had, or whose father had, the MTRR 66GG genotype: ORs 0.60 [95% confidence interval (CI) 0.39–0.91] and 0.64 (95% CI, 0.40–1.03), respectively. The ORs for paternal MTHFR 677CT and TT genotypes were 1.41 (95% CI, 1.02–1.93) and 1.81 (95% CI, 1.06–3.07). ORs varied little by maternal folic acid supplementation.Conclusions: Some folate pathway gene polymorphisms in the child or a parent may influence ALL risk. While biologically plausible, underlying mechanisms for these associations need further elucidation.Impact: Folate pathway polymorphisms may be related to risk of childhood ALL, but larger studies are needed for conclusive results. Cancer Epidemiol Biomarkers Prev; 24(1); 48–56. ©2014 AACR.
G-Protein Estrogen Receptor as a Regulator of Low-Density Lipoprotein Cholesterol Metabolism
Authors: Hussain Yasin , Ding Qingming , Connelly Philip W. , Brunt J. Howard , Ban Matthew R. , McIntyre Adam D. , Huff Murray W. , Gros Robert , Hegele Robert A. , Feldman Ross D. 
Published: November 2014

Objective—
Estrogen deficiency is linked with increased low-density lipoprotein (LDL) cholesterol. The hormone receptor mediating this effect is unknown. G-protein estrogen receptor (GPER) is a recently recognized G-protein–coupled receptor that is activated by estrogens. We recently identified a common hypofunctional missense variant of GPER, namely P16L. However, the role of GPER in LDL metabolism is unknown. Therefore, we examined the association of the P16L genotype with plasma LDL cholesterol level. Furthermore, we studied the role of GPER in regulating expression of the LDL receptor and proprotein convertase subtilisin kexin type 9.

Approach and Results—

Our discovery cohort was a genetically isolated population of Northern European descent, and our validation cohort consisted of normal, healthy women aged 18 to 56 years from London, Ontario. In addition, we examined the effect of GPER on the regulation of proprotein convertase subtilisin kexin type 9 and LDL receptor expression by the treatment with the GPER agonist, G1. In the discovery cohort, GPER P16L genotype was associated with a significant increase in LDL cholesterol (mean±SEM): 3.18±0.05, 3.25±0.08, and 4.25±0.33 mmol/L, respectively, in subjects with CC (homozygous for P16), CT (heterozygotes), and TT (homozygous for L16) genotypes (
P
<0.05). In the validation cohort (n=339), the GPER P16L genotype was associated with a similar increase in LDL cholesterol: 2.17±0.05, 2.34±0.06, and 2.42±0.16 mmol/L, respectively, in subjects with CC, CT, and TT genotypes (
P
<0.05). In the human hepatic carcinoma cell line, the GPER agonist, G1, mediated a concentration-dependent increase in LDL receptor expression, blocked by either pretreatment with the GPER antagonist G15 or by shRNA-mediated GPER downregulation. G1 also mediated a GPER- and concentration-dependent decrease in proprotein convertase subtilisin kexin type 9 expression.

Conclusions—
GPER activation upregulates LDL receptor expression, probably at least, in part, via proprotein convertase subtilisin kexin type 9 downregulation. Furthermore, humans carrying the hypofunctional P16L genetic variant of GPER have increased plasma LDL cholesterol. In aggregate, these data suggest an important role of GPER in the regulation of LDL receptor expression and consequently LDL metabolism.
In Vivo Nanoparticle Assessment of Pathological Endothelium Predicts the Development of Inflow Stenosis in Murine Arteriovenous Fistula
Authors: Cui Jie , Kessinger Chase W. , McCarthy Jason R. , Sosnovik David E. , Libby Peter , Thadhani Ravi I. , Jaffer Farouc A. 
Published: November 2014

Objective—
In vivo assessment of pathological endothelium within arteriovenous fistula (AVF) could provide new insights into inflow stenosis, a common cause of AVF primary failure in end-stage renal disease patients. Here we developed nanoparticle-based imaging strategies to assess pathological endothelium in vivo and elucidate its relationship to neointimal hyperplasia formation in AVF.

Approach and Results—

Jugular-carotid AVFs were created in C57BL/6 mice (n=38). Pathological endothelium in the AVF was visualized and quantified in vivo using dextranated magnetofluorescent nanoparticles (CLIO-VT680 [cross-linked iron oxide-VivoTag680]). At day 14, CLIO-VT680 was deposited in AVF, but only minimally in sham-operated arteries. Transmission electron microscopy revealed that CLIO-VT680 resided within endothelial cells and in the intimal extracellular space. Endothelial cells of AVF, but not control arteries, expressed vascular cell adhesion molecule-1 and showed augmented endothelial permeability near the anastomosis. Intravital microscopy demonstrated that CLIO-VT680 deposited most intensely near the AVF anastomosis (
P
<0.0001). The day 14 intravital microscopy CLIO-VT680 signal predicted the subsequent site and magnitude of AVF neointimal hyperplasia at day 42 (
r
=0.58,
P
<0.05). CLIO-VT680 deposition in AVF was further visualized by ex vivo MRI.

Conclusions—
AVF develop a pathological endothelial response that can be assessed in vivo via nanoparticle-enhanced imaging. AVF endothelium is activated and exhibits augmented permeability, offering a targeting mechanism for nanoparticle deposition and retention in pathological endothelium. The in vivo AVF nanoparticle signal identified and predicted subsequent inflow neointimal hyperplasia. This approach could be used to test therapeutic interventions aiming to restore endothelial health and to decrease early AVF failure caused by inflow stenosis.