bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical assessment of uncertainty and performance of multiple satellite-based precipitation products in capturing extreme precipitation events across Punjab Province, Pakistan
Authors: Sultan Umar , Laraib Muhammad , Ilyas Muhammad Ahmad , Ahmad Muhammad , Abbas Khawar , Khan Hayat Ullah , Arshed Abu Bakar , Khalid Obaid 
Published: August 2024

ABSTRACT

The changing climate poses a significant danger to both environment and humans. Precipitation stands out as a critical factor for impacting hydrology, ecology, agriculture, and vegetation as well as crucial for maintaining the atmospheric equilibrium. This research examined four satellite-based precipitation products spanning from 2010 to 2018, focusing on assessing the uncertainty associated with these products in Punjab Province, Pakistan. Additionally, a comparative analysis of multi-satellite-derived precipitation data was conducted for the region. Various evaluation metrics, including CC, RMSE, Bias, rBias, and POD, were employed to gauge the performance of these datasets throughout the study area. Our research yielded the following findings: (1) datasets CHIRP and SM2RAIN exhibited the capability of capturing temporal changes observed in precipitation throughout the study area. (2) All satellite-derived datasets displayed superior performance on a monthly basis compared to daily timeframes. (3) On a seasonal scale, CHIRP and SM2RAIN exhibited superior precipitation detection capabilities compared to PERSIANN-CCS and PERSIANN-CDR. (4) CHIRP and SM2RAIN exhibited superior performance across all seasons when compared to PERSIANN-CCS and PERSIANN-CDR. Nonetheless, all products exhibited reasonably accurate detection of light to moderate precipitation events. This study serves to establish a foundation for effective monitoring, mitigation, and decision-making processes.
Analysis of Key Genes Related to Systemic Lupus Erythematosus and COVID-19
Authors: Guan Rui , Yu Jing , Zheng Jiannan , Zhao Yeyu , Zhang Bolun , Wang Min , Gao Mingli 
Published: August 2024

Background:
Systemic Lupus Erythematosus (SLE) is a multifactorial and complex
immune disease; however, the relevance of COVID-19 infection in SLE patients remains uncertain.

Aim:
This study aims to explore the key candidate genes and pathways in patients with SLE. It
also seeks to employ bioinformatics analysis to unravel the molecular signatures inherent in both
SLE and COVID-19 patients. The ultimate aim is to identify potential targets and markers specifically
relevant to SLE patients who contract SARS-CoV-2.

Methods:
Datasets (GSE12374, GSE20864, GSE61635, GSE81622, and GSE144390) from the
Gene Expression Omnibus (GEO) database were analyzed using Robust Rank Aggregation
(RRA) method to identify differential expression genes (DEGs) in SLE patients compared to
healthy individuals. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes
(KEGG) pathway analysis, tissue-specific gene analysis, and Protein-protein interaction (PPI)
network were performed. Finally, the Venn diagram was employed to identify the intersections
of COVID-19 genes, serving as potential targets for SLE patients with COVID-19 infection.

Results:
A total of 154 DEGs were discovered, with GO enrichment indicating a predominant
involvement in the defense response against the virus (P<0.001). KEGG pathway analysis
showed enrichment in the NOD-like receptor signaling pathway and coronavirus disease, specifically
COVID-19 (P<0.001). Tissue-specific genes related to the hematological and immune systems
were emphasized (74%). The PPI network highlighted 22 genes, and 5 key genes, namely,
IFIT1, IFIT3, MX1, MX2, and OAS3, which were identified after intersecting with COVID-19
patients’ data.

Conclusion:
IFIT1, IFIT3, MX1, MX2, and OAS3 exhibiting differential expression, as well as
the pathways associated with COVID-19, could potentially function as biomarkers and therapeutic
targets for individuals with SLE infected with COVID-19.
Advancements in Cancer Therapeutics: Current Paradigms in Applying Biodegradable Polymer Nanoparticles for Enhanced Management
Authors: Grewal Sonam , Deswal Geeta , Chopra Bhawna , Dhingra Ashwani Kumar , Kriplani Priyanka , Guarve Kumar , Grewal Ajmer Singh 
Published: August 2024

Abstract:
The development of novel colloidal formulations that can regulate the pharmacological
and biological properties of medications has been made possible by the developments of nanotechnology.
Biodegradable nanoparticles were exploited as drug delivery methods because of their
high bioavailability, improved encapsulation, controlled release, and less toxic characteristics.
Over the past few decades, a variety of synthetic polymers have been investigated for application
in nanomedicine, particularly in drug delivery systems. Drug delivery polymers need to be environmentally
friendly, biodegradable, and biocompatible. As they have the ability to provide targeted
delivery to a specified site, polymeric nanoparticles have the potential to increase the effectiveness
of cancer therapies significantly. It is possible to modify the physical and chemical characteristics
of polymers to provide delivery across the many biological barriers needed to reach different
cell subsets. The use of biodegradable polymers as nanocarriers is particularly appealing since
these materials can be developed to show triggered functionality at certain locations or activated
by an external source in addition to degrading under physiological circumstances. Biodegradable
polymers can be developed as easy drug-delivery systems that specifically target the tumour microenvironment.
This is because these nanomedicines can directly target cancer cells, as well as
blood vessels that supply the nutrition and oxygen required for tumour growth and immune cells
that support anti-cancer immunotherapy. With the advancements in nanotechnology-based drug delivery
systems for pharmaceutical applications, it is exciting to examine and highlight the significance
of polymeric nanocarrier systems for drug delivery in chemotherapy.
Modeling of Interpretable Fuzzy Rule-based System for the Classification of Thyroid Disease
Authors: Kant Shashi , Agarwal Devendra , Shukla Praveen Kumar 
Published: August 2024

Introduction:
The ability of fuzzy rule-based systems to handle the imprecision
and uncertainty present in real-world problems is quite impressive. The assessment of any
fuzzy rule-based system in itself is a complex task because its performance is dependent on
two parameters, namely accuracy and interpretability. Accuracy is assessed based on quantitative
results, whereas interpretability is entirely subjective and may vary according to domain
expertise.

Methods:
To develop an efficient fuzzy rule-based system, interpretability and accuracy should
be taken into account, along with a good trade-off relationship between them. An interpretable
fuzzy rule-based system has been developed in this paper for the classification of thyroid disease
for an accurate diagnosis and prognosis of the thyroid.

Result:
The knowledge base for the classifier is built using three fuzzy rule induction algorithms
(fuzzy decision tree, Wang Mendel, and fast prototyping) and two membership function
generation schemes (k-means and HFP). Using these rule induction algorithms and membership
functions, six different fuzzy-based classifiers have been suggested to deal with thyroid
disorders, and their performance has been evaluated using accuracy and interpretability parameters.

Conclusion:
Among them, using hfp and kmeans partition with fuzzy decision tree rule induction
algorithm, the classifier attained the highest accuracy of 95.8% and 93.5% with a good interpretability
factor of 0.023 and 0.033, respectively, which shows a quite satisfactory result.
Comparison of Several Methods for Analysis Slope Length Index Factor at A Watershed Scale
Authors: Faisol Arif , Mashudi Mashudi , Bachri Samsul 
Published: August 2024

Slope length and steepness factor index (LS) is one of the parameters for the Universal Soil Loss Equation (USLE) to estimate soil erosion. Currently, several methods for LS analysis, i.e. Wischmeier-Smith, Moore-Nieber, and Desmet – Govers. This study aims to compare the Wischmeier-Smith method, Moore–Nieber method, and Desmet–Govers method to analyze LS in the watershed in Manokwari – West Papua. This research consists of 4 main stages, i.e. data inventory, watershed boundary delineation, LS analysis, and LS comparison. The research showed that the Wischmeier-Smith method gave a higher LS value than the Moore – Nieber method and the Desmet – Govers method. Meanwhile, the Desmet – Gover method gives a lower average LS value than the Wischmeier-Smith method and the Moore – Nieber method. Based on the T-test, the LS produced by the Wischmeier-Smith, Moore-Nieber, and Desmet–Govers methods has significant differences in analyzing LS in the watershed in Manokwari – West Papua. Keywords: Desmet – Govers, Moore – Nieber, Universal Soil Loss Equation, Watershed, Wischmeier-Smith
Avis de publication : Outil de données sur les indicateurs de la santé périnatale (ISP)
Authors: Metcalfe Stephanie , Lye Jennifer , Liang Hongbo , Arscott Holly , Nelson Chantal , Luo Wei 
Published: August 2024

Résumé

La Section de la santé maternelle et infantile de l’agence de la santé publique du Canada (ASPC) a le plaisir d'annoncer une mise à jour de données sur les indicateurs de la santé périnatale (ISP). L'outil de données interactif se trouve sur le site Web de l'Infobase de l'ASPC et présente les statistiques sur la santé maternelle, foetale et infantile au Canada fondées sur les données de la Base de données sur les congés des patients (BDCP) de l’Institut canadien d’information sur la santé (ICIS), de l’Enquête sur la santé dans les collectivités canadiennes (ESCC) et de la Base canadienne de données de l’état civil (bases de données sur les naissances, les mortinaissances et les décès). Les données comprennent 20 indicateurs regroupés en quatre principaux domaines de la santé: comportements et pratiques en santé, services de santé, santé maternelle et santé infantile. Dans le cadre de cette mise à jour, cinq nouveaux indicateurs ont été ajoutés et trois indicateurs existants ont été modifiés. Pour accéder au plus récent outil de données sur les indicateurs de la santé périnatale, consultez le : https://sante-infobase.canada.ca/isp/.
ANALISIS STRATEGI PEMASARAN UNTUK MENINGKATKAN PENJUALAN PADA UMKM BEDHAG COFFEE DI KABUPATEN JEMBER
Authors: Maulidina Niswah Saffanah , Nurayuni Kholifa Dinda , Wicaksono Ryan Alhafidz , Hamzah Muhammad Ali , Ramadhan Gilang , Prabowo Rachmat Udhi 
Published: August 2024

AbstrakKabupaten Jember merupakan salah satu kabupaten yang memiliki potensi tumbuhnya tanaman kopi berkualitas. Rasa yang unik membuat kopi asal Jember dikenal baik secara nasional maupun internasional. Bedhag Coffee merupakan salah satu UMKM dibidang kopi. Kurang maksimalnya pemasaran dan distribusi merupakan salah satu kendala dari Bedhag Coffee. Penelitian ini dilakukan untuk menganalisis strategi pemasaran yang tepat untuk UMKM Bedhag Coffee. Analisis yang dilakukan adalah dengan menggunakan SWOT (Strength, Weakness, Opportunities, and Threats). Bedhag Coffee belum banyak mengembangkan jangkauan pasar hal ini dikarenakan keterbatasan media pemasaran dan inovasi produk serta keterbatasan bahan baku yang menjadi penghambat untuk usaha roastery kopi ini berkembang dengan baik. Strategi yang dapat dilakukan adalah mempromosikan dan mengunggulkan cita rasa kopi, memperbanyak relasi, membangun dan memperluas branding media sosial yang baik, dan membuat inovasi produk yang menarik.Kata Kunci: kopi, bedhag coffee, strategi pemasaran, dan SWOTAbstractJember Regency is one of the regencies that has the potential to grow quality coffee plants. The unique flavor makes coffee from Jember known both nationally and internationally. Bedhag Coffee is one of the MSMEs in the coffee sector. The lack of maximization of marketing and distribution is one of the obstacles of Bedhag Coffee. This research was conducted to analyze the right marketing strategy for Bedhag Coffee. The analysis carried out is by using SWOT (strength, weakness, opportunities, and threats). Bedhag Coffee has not developed much market reach, this is due to limited marketing media and product innovation as well as limited raw materials which are obstacles to this coffee roastery business developing well. Strategies that can be done are promoting and favoring coffee flavors, increasing relationships, building and expanding good social media branding, and making interesting product innovations.Keywords: coffee, bedhag coffee, marketing strategy, and SWOT
A selfie with musical expression in the background. An attempt at heuristics
Authors: Bilica Krzysztof 
Published: August 2024

Abstract
A selfie with musical expression in the background is a metaphor. We take a selfie to see a reflection of ourselves. However, the photograph also enables us to see what surrounded us and what we did not really pay attention to. Let us try to capture the essence of expression in such a metaphorical selfie. We will need additional mirrors: a mirror of language and a mirror of music, as well as a strong (logical!) insight into the real manifestations of language (speech and writing) and the real manifestations of music (sounding music – musica sonabilis and written music – musica scripta), into the relations between the manifestations of language and the manifestations of music, and into the differences between them, and finally into what and how they can express (we can express through them).
PERSEPSI PENGGUNA LRT JABODEBEK STASIUN HARJAMUKTI
Authors: Imantaka Eldwin , Najid  , Angkat Hokbyan R.S. 
Published: August 2024

Light Rail Transit (LRT) is a type of train that allows people who own private vehicles to switch to mass transportation. The purpose of LRT is to reduce congestion in Jabodebek. Both facilities and services support the use of mass transportation. The purpose of research is see the perceptions users of LRT Jabodebek LRT at Harjamukti Station. This station is a station that has been opened and serves to help people around Cibubur to Jakarta. The Cibubur community has several disadvantages when heading to the Harjamukti LRT station. One of them is the distance between the parking lot and the Harjamukti LRT station. In addition, the limit of public transportation that drops off passengers makes the Harjamukti LRT station still too far away. A survey on the perception of Harjamukti Station LRT users was conducted by distributing questionnaires to 120 people.
ANALISIS PANJANG PENGANGKURAN TERHADAP KUAT TARIK MAKSIMUM MENGGUNAKAN APLIKASI MIDAS FEA NX
Authors: Christianto Daniel , Audrian Nikita , Victoria Gabriella , Leo Edison 
Published: August 2024

Anchors are one of the commonly used connecting methods, that are used to connect structural elements with concrete or other materials and are used not only in new structures but also in existing structures. The installation system can be done by cast in place or post-installed. One type of post-installed anchor is an adhesive anchor which is widely used in strengthening concrete structures because of its installation efficiency. One of the factors that determine the anchor’s tensile strength is the embedment length, where the anchor transmits force from or to the surrounding concrete. The research used the finite element method using Midas FEA NX. Modeling was made with anchor diameters of 10 mm, 12 mm, 16 mm, 19 mm, concrete strength of 20 MPa, 25 MPa, 30 MPa, 35 MPa, and anchor embedding depths of 3d, 6d, 105 mm, 150 mm. Then, a tensile test is carried out on the anchors to obtain the tensile capacity value of each anchor. The analysis is carried out in nonlinear static with vertical loads in displacement approach. Based on the analysis results, it can be concluded that the deeper the anchor embedment length, the greater the anchor's tensile capacity.
Abstrak
Angkur adalah salah satu metode penghubung yang umum digunakan, tujuannya untuk menghubungkan elemen struktural dengan beton atau material lainnya dan digunakan bukan hanya pada struktur baru tetapi juga pada struktur yang sudah ada. Sistem pemasangannya dapat dilakukan sebelum (cor di tempat) ataupun sesudah beton mengeras (pasca pasang). Salah satu tipe angkur pasca pasang adalah angkur adhesif yang saat ini banyak digunakan dalam perkuatan struktur beton karena pemasangannya lebih efisien. Salah satu pengaruh kuat tarik angkur adalah berdasarkan dari kedalaman penanaman angkur, dimana angkur menyalurkan gaya dari atau menuju beton di sekelilingnya. Penelitian dilakukan dengan metode elemen hingga menggunakan Midas FEA NX. Pemodelan dibuat dengan diameter angkur 10 mm, 12 mm, 16 mm, 19 mm, mutu beton 20 MPa, 25 MPa, 30 MPa, 35 MPa, serta kedalaman penanaman angkur sebesar 3d, 6d, 105 mm, 150 mm. Setelah itu dilakukan pengujian tarik pada angkur untuk mendapatkan nilai kapasitas tarik masing-masing angkur. Analisis dalam Midas FEA NX dilakukan secara nonlinear statik dengan beban secara vertikal menggunakan pendekatan perpindahan dan mengetahui jenis keruntuhan yang terjadi. Berdasarkan hasil analisis, semakin dalam penanaman angkur maka semakin besar pula kapasitas tarik angkur.
Tempo de tela e a repercussão cognitiva em adolescentes
Authors: Frota Flavio Patryck de Araújo , Porto Guilherme Rodrigues , Dias Filho Carlos Alberto Alves 
Published: August 2024

Objetivo: Investigar a relação entre tempo de tela e a repercussão cognitiva em adolescentes, analisando estudos pertinentes. Métodos: Trata-se de uma revisão integrativa referente à relação entre tempo de tela e repercussão cognitiva em adolescentes conduzida no período entre os anos 2021 e 2023, utilizando a base de dados PubMed, os descritores em Ciências da Saúde (DeCS) “Tempo de tela”, “Cognição” e “adolescentes”. Resultados: Foram selecionados 6 artigos para análise. Os estudos revisados apresentam evidências de uma associação significativa entre tempo de tela e repercussão cognitiva em adolescentes, associações consistentes com problemas de saúde mental, sono perturbado e risco de distúrbios cognitivos. A luz azul dos dispositivos afeta negativamente o sono ao suprimir a produção de melatonina e perturbar o ritmo circadiano, levando a dificuldades para adormecer e uma qualidade de sono reduzida. Considerações finais: A relação entre o tempo de tela na adolescência e os desafios de saúde mental e cognitiva é multifacetada, envolvendo fatores socioeconômicos, comportamentais e tecnológicos. Intervenções personalizadas e abordagens holísticas são essenciais para mitigar os efeitos negativos e promover um equilíbrio saudável no uso de dispositivos digitais.
Effect of behavior change plan on the wellness of dental students
Authors: Phate Vrushali Vijay , Deshpande Saee 
Published: August 2024

Objectives:
The purpose of this study was to evaluate the efficacy of a behavior change plan (BCP) on the well-being of dental students.

Material and Methods:
First and second-year bachelor of dental surgery (BDS) students were sensitized regarding the importance of a healthy lifestyle and asked to choose any one/more areas of fitness to improve on. Pre-test scores were recorded. For the next 6 months, follow-up reminders were given to keep them on track. Post-test scores were recorded at the end of 6 months.

Results:
Overall wellness score showed improvement at the end of 6 months, maximum students completed their target behavior.

Conclusion:
A BCP is an effective method to inculcate principles of a healthy lifestyle among dental undergraduates.
Collision tumor comprised of chronic lymphocytic leukemia and myxopapillary ependymoma
Authors: Aly Ahmed , Nagaraju Santhosh , Price Rupert 
Published: August 2024

Background:
Collision tumors involving the co-occurrence of two morphologically and genomically distinct neoplasms in the same anatomical site are exceptionally rare in the central nervous system (CNS).

Case Description:
We report a unique case of a CNS collision tumor comprising chronic lymphocytic leukemia and myxopapillary ependymoma in a 77-year-old male with acute neurological decline. Presumed to represent leukemic infiltration, urgent laminectomy was pursued for tissue diagnosis and spinal cord decompression, revealing the unexpected ependymal component.

Conclusion:
This case highlights the diagnostic and therapeutic challenges inherent to managing collision CNS tumors, particularly when one neoplasm is hematological.
ANTIVIRAL ACTIVITY AND THERAPEUTIC AND PREVENTIVE EFFECT OF PHOSPHONOACETIC ACID AND ITS DERIVATIVES
Authors: Зубаиров М. М. , Селянинов Ю. О. , Рощин А. В. , Хохлов П. С. 
Published: August 2024

Изучено антивирусное (вирусстатическое) действие 127 производных фосфонуксусной кислоты в культуре клеток костного мозга свиней, из которых для изучения лечебно-профилактического действия было отобрано и испытано 16 веществ. На основе анализа данных об эффективности синтеза, воспроизводимости и лечебной активности при африканской чуме свиней (АЧС) были отобраны три соединения - фосфонуксусная кислота, комплекс фосфонуксусной кислоты с 7-амино-1,3,5-триазаадамантаном (А-14) и калиевая пиридиновая соль фосфонуксусной кислоты (Ф-230), которые предохраняли от гибели более 80% зараженных животных при 100% гибели в контроле. Применение фосфонуксусной кислоты в комплексе с метисазоном в условиях микроэпизоотии предохраняло от гибели всех подсвинков, бывших в контакте с больными, при 100% гибели животных, которым соединение не вводили. Показана возможность (отработаны дозы, сроки и кратности введения химиопрепаратов) для снятия вирусоносительства при АЧС. Установлена возможность получения типоспецифических сывороток, минуя процесс аттенуации вирулентных штаммов. Это позволяет сократить время получения сыворотки в 3-12 раз, что имеет важное значение для серотипирования вируса, так как для аттенуации отдельных штаммов требуется от 6 до 12 и более месяцев. Результаты дают возможность разработки рекомендаций и мероприятий по борьбе с АЧС.
Abstract - Antiviral (virustatic) activity of 127 derivatives of phosphonoacetic acid was examined in porcine bone marrow cell culture; consequently, 16 of them were selected and tested for studying their therapeutic and prophylactic effect. Analysis of combined data on their synthesis efficiency, reproducibility, and therapeutic activity against African swine fever (ASF) resulted in choosing three compounds, i.e. phosphonoacetic acid, phosphonoacetic acid complex with 7-amino-1,3,5-triazaadamantane, and potassium pyridine salt of phosphonoacetic acid, all of which prevented mortality of more than 80% of infected animals versus 100% mortality of animals in control group. The use of phosphonoacetic acid in combination with metisazone under microepizootic conditions prevented mortality of all piglets contacted with the diseased ones, in comparison to 100% mortality in untreated animals. A possibility for virus carriage removal under ASF was shown (dosages, terms and frequency of chemotherapeutic agent administration were determined). The possibility of obtaining type-specific sera was established which left out the step of attenuation of virulent strains. The result allowed to shorten the serum preparation time by 3-12 times which might be crucial for serotyping the virus, since attenuation of individual strains can take up to 6-12 months or more. The results contribute to developing recommendations and measures against ASF.