bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODERATION IN INDONESIAN TAFSIR: CRITICAL DISCOURSE ANALYSIS OF THE TERMS OF UMMATAN WASATAN IN THE AL-QUR’AN DAN TERJEMAHANNYA BY THE MINISTRY OF RELIGION OF THE REPUBLIC OF INDONESIA
Authors: Cholily Naufal 
Published: August 2024

Various kinds of religious issues in the context of the state, such as intolerance between religious communities, have made the state formulate a program of religious moderation through the Kementerian Agama RI in 2019. The importance of this program can be seen from the inclusion of religious moderation in the Konsep Rencana Pembangunan Jangka Menengah Nasional 2020-2024 by Bappenas. On the other hand, the Ministry of Religion has been producing Qur’anic literature for a long time through the Al-Qur’an dan Terjemahnya, Al-Qur’an dan Tafsirnya, Tafsir Tematik Moderasi Beragama, and others. This article attempts to trace the meaning of religious moderation through Al-Qur’an dan Terjemahnya from time to time (1990 and 2019 editions), with the following questions: How do the products of the Al-Qur’an Terjemah Kemenag discuss religious moderation? The meaning of the word tawasut will be traced from the Al-Qur’an dan Terjemahnya from time to time. This research is a text analysis (content analysis) with a qualitative research method that comes from two main data sources, namely primary data and secondary data. Furthermore, processing the data is done by using the literature mapping technique. The conclusions obtained from these two editions do not exist in a vacuum. Texts were produced according to the context and socio-political setting of the time. After analyzing through text dimensions, discursive practices and sociocultural practices, it was found that the construction of ideology in the structure of the text can be seen in the translation changes in the two verses. Expanding the meaning and euphemism of the terms used responds to the context surrounding the Qur’an and its translation by the Kementerian Agama RI. The production and consumption of texts can then be seen from government policies through the Kementerian Agama in the socialization of moderation in all lines of people’s lives, in religion, intellectuals and society.
Metagenomic next-generation sequencing promotes pathogen detection over culture in joint infections with previous antibiotic exposure
Authors: Gao Zongyan , Zheng Wendi , Zhang Meng , Gao Yanhua , Huang Jincheng , Chen Xiao , Dai Zhipeng , Song Zhenyu , Feng Jiawei , Cao Qianqian , Jin Yi 
Published: August 2024

ObjectiveTo investigate the diagnostic value of metagenomic next-generation sequencing (mNGS) in detecting pathogens from joint infection (JI) synovial fluid (SF) samples with previous antibiotic exposure.MethodsFrom January 2019 to January 2022, 59 cases with suspected JI were enrolled. All cases had antibiotic exposure within 2 weeks before sample collection. mNGS and conventional culture were performed on SF samples. JI was diagnosed based on history and clinical symptoms in conjunction with MSIS criteria. The diagnostic values, including sensitivity, specificity, positive/negative predictive values (PPV/NPV), and accuracy, were in comparison with mNGS and culture.ResultsThere were 47 of the 59 cases diagnosed with JI, while the remaining 12 were diagnosed with non-infectious diseases. The sensitivity of mNGS was 68.1%, which was significantly higher than that of culture (25.5%, p&lt;0.01). The accuracy of mNGS was significantly higher at 71.2% compared to the culture at 39.0% (p &lt;0.01). Eleven pathogenic strains were detected by mNGS but not by microbiological culture, which included Staphylococcus lugdunensis, Staphylococcus cohnii, Finegoldia magna, Enterococcus faecalis, Staphylococcus saprophytics, Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa, Acinetobacter pittii, Brucella ovis, andCoxiella burnetii. Antibiotic therapy was adjusted based on the mNGS results in 32 (68.1%) patients, including 12 (25.5%) and 20 (42.6%) patients, in whom treatment was upgraded and changed, respectively. All JI patients underwent surgery and received subsequent antibiotic therapy. They were followed up for an average of 23 months (20-27 months), and the success rate of treatment was 89.4%. Out of the 33 patients who had positive results for pathogens, reoperation was performed in 1 case (3.03%), while out of the 14 cases with negative results for both mNGS and cultures, reoperation was performed in 4 cases (28.6%).ConclusionsmNGS has advantages over conventional culture in detecting pathogens in SF samples from JI patients previously treated with antibiotics, potentially improving clinical outcomes.
Decitabine-based treatment strategy improved the outcome of HSCT in JMML: a retrospective cohort study
Authors: Peng Zhiyong , Gao Jingyu , Huang Litao , He Yuelin , Tang Haoran , Zong Sa , Pei Yanru , Pei Fuyu , Ge Jing , Liu Xuan , Yue Li , Zhou Jun , Li Xia , Yue Dan , Chen Yun , Chen Chen , Wu Xuedong , Feng Xiaoqin , Li Chunfu 
Published: August 2024

IntroductionPre-HSCT disease control, suboptimal long-term prognosis, and a high recurrence incidence (RI) continue to pose significant challenges for hematopoietic stem cell transplantation (HSCT) in juvenile myelomonocytic leukemia (JMML) patients.MethodsThis retrospective cohort study assessed the effectiveness of a decitabine (DAC)-based protocol in JMML patients undergoing HSCT. The pre-HSCT treatment includes initial and bridging treatment. The efficacy of DAC monotherapy versus DAC combined with cytotoxic chemotherapy(C-DAC) as initial treatment was compared, followed by DAC plus FLAG (fludarabine, cytarabine, and GCSF) as bridging treatment. The HSCT regimens were based on DAC, fludarabine, and busulfan. Post-HSCT, low-dose DAC was used as maintenance therapy. The study endpoints focused on pretransplantation simplified clinical response and post-HSCT survival.ResultsThere were 109 patients, including 45 receiving DAC monotherapy and 64 undergoing C-DAC treatment. 106 patients completed bridging treatment. All patients were administered planned HSCT regimens and post-HSCT treatment. The initial treatment resulted in 88.1% of patients achieving clinical remission without a significant difference between the DAC and C-DAC groups (p=0.769). Clinical remission rates significantly improved following bridging treatment (p=0.019). The 5-year overall survival, leukemia-free survival, and RI were 92.2%, 88.4%, and 8.0%, respectively. A poor clinical response to pre-HSCT treatment emerged as a risk factor for OS (hazard ratio: 9.8, 95% CI: 2.3-41.1, p=0.002).ConclusionImplementing a DAC-based administration strategy throughout the pre-HSCT period, during HSCT regimens, and in post-HSCT maintenance significantly reduced relapse and improved survival in JMML patients. Both DAC monotherapy and the DAC plus FLAG protocol proved effective as pre-HSCT treatments.
Plant growth-promoting rhizobacteria enhance active ingredient accumulation in medicinal plants at elevated CO2 and are associated with indigenous microbiome
Authors: Ng Charles Wang Wai , Yan Wen Hui , Xia Yi Teng , Tsim Karl Wah Keung , To Justin Chun Ting 
Published: August 2024

IntroductionPlant growth-promoting rhizobacteria (PGPR) and elevated CO2 (eCO2) have demonstrated their individual potential to enhance plant yield and quality through close interaction with rhizosphere microorganisms and plant growth. However, the efficacy of PGPR under eCO2 on rhizosphere microbiome and, ultimately, plant yield and active ingredient accumulation are not yet fully understood.MethodsThis study investigated how the medicinal plant Pseudostellaria heterophylla (P. heterophylla) and its rhizosphere microbes respond to PGPR (Bacillus subtilis and Pseudomonas fluorescens) at eCO2 (1,000 ppm).Results and DiscussionIt was found that the yield and active ingredient polysaccharides accumulation in the tuber of P. heterophylla were significantly increased by 38 and 253%, respectively. This promotion has been associated with increased root development and changes in the indigenous microbial community. Metagenomics analysis revealed a significant reduction in pathogenic Fusarium abundance in the rhizosphere. Potential biocontrol bacteria Actinobacteria and Proteobacteria were enriched, especially the genera Bradyrhizobium and Rhodanobacter. The reshaping of the rhizosphere microbiome was accompanied by the upregulation of biological pathways related to metabolite biosynthesis in the rhizosphere. These modifications were related to the promotion of the growth and productivity of P. heterophylla. Our findings highlighted the significant role played by PGPR in medicinal plant yield and active ingredient accumulation when exposed to eCO2.
Global hotspots and research trends of radiation-induced skin injury: a bibliometric analysis from 2004 to 2023
Authors: Hu Yungang , Yu Lu , Du Weili , Hu Xiaohua , Shen Yuming 
Published: August 2024

BackgroundRadiation therapy has become an important treatment for many malignant tumours after surgery and for palliative tumour care. Although modern radiotherapy technology is constantly improving, radiation damage to normal tissues is often difficult to avoid, and radiation-induced skin injury (RSI) is a common complication, manifested as skin erythema, peeling, ulceration, and even bone and deep organ damage, seriously affect the quality of life for patients. Basic research and clinical trials related to RSI have achieved certain results, while no researchers have conducted comprehensive bibliometric studies.ObjectiveA comprehensive bibliometric analysis of publications on RSI published between 2004 and 2023 was conducted to identify current hotspots and future directions in this area of study.MethodsRSI-related publications published between January 1, 2004, and December 31, 2023, were retrieved from the Web of Science Core Collection (WoSCC) database for analysis using VOSviewer and CiteSpace analytics.ResultsA total of 1009 publications on RSI from 2004 to 2023 were included in the WoSCC database. The United States had the highest productivity with 299 papers, accounting for 29.63% of the total production, followed by China with 193 papers (19.13%) and Japan with 111 papers (11.00%). In terms of research institutions and journals, the University of Toronto and Journal of Supportive Care in Cancer published the highest number of papers. Professor Edward Chow published the most articles, while Professor Shuyu Zhang was the most cited. The top ten most-cited papers focused on the pathogenesis, prevention, and management of RSI. Keyword co-occurrence analysis and the top 25 keywords with the strongest citation bursts suggest that current research focuses on the pathogenesis, prevention, and treatment management of RSI.ConclusionThis study conducted a systematic bibliometric analysis of RSI publications from 2004 to 2023; identified the trends in RSI publications, major research countries, major research institutions, major research journals, major research authors, and major research keywords; and revealed the future development direction and research hotspots of this field. This study provides a valuable reference for future RSI research.
Simulated fire video collection for advancing understanding of human behavior in building fires
Authors: Bonny Justin W. , Hussain Zishanul , Russell Micah D. , Trouvé Arnaud , Milke James A. 
Published: August 2024

IntroductionThe goal of the present research was to develop a video collection of simulated fires to investigate how people perceive growing building fires. In fire safety science, a critical factor to occupant responses to building fires is the pre-movement period, determined by how long it takes an individual to initiate taking protective action with an incipient fire. Key to studying the psychological processes that contribute to the duration of the pre-movement period is presenting human subjects with building fires. One approach used in previous research is to present videos of building fires to individuals via scenarios. The numerical simulations used to model fire dynamics can be used to render videos for these scenarios. However, such simulations have predominantly been used in fire protection engineering to design buildings and are relatively inaccessible to social scientists.MethodThe present study documents a collection of videos, based on numerical simulations, which can be used by researchers to study human behavior in fire. These videos display developing fires in different types of rooms, growing at different rates, different smoke thickness, among other characteristics. As part of a validation study, participants were presented with subsets of the video clips and were asked to rate the perceived risk posed by the simulated fire.Results and discussionWe observed that ratings varied by the intensity and growth rate of the fires, smoke opacity, type of room, and where the viewpoint was located from the fire. These effects aligned with those observed in previous fire science research, providing evidence that the videos could elicit perceived risk using fire simulations. The present research indicates that future studies can utilize the video library of fire simulations to study human perceptions of developing building fires as situational factors are systematically manipulated.
Regional differences in the Association of Healthy Aging with the incidence of falls: an analysis based on the China Health and Retirement Longitudinal Study from 2011 to 2020
Authors: Li Xiang , Wei Chao , Hu Kejing , Sun Jie , Gao Xiang , Yang Jianhong 
Published: August 2024

BackgroundFalls frequently occur among the older adult population. In this study, we examined the variations in fall incidence across different regions over time, focusing on the disparities between urban and rural areas among older adult Chinese individuals, Healthy aging is comprised of five dimensions: (1) absence of chronic diseases, (2) good physical functioning, (3) normal cognitive function, (4) active social participation, and (5) absence of depression. Additionally, we explored the relationship between healthy aging and the occurrence of falls in middle-aged and older adults. Falls are defined as events that occurred within the past two years.ResultsAmong 9,918 participants, 33.8% lived in urban areas and 23.0% achieved healthy aging. In contrast, 66.2% resided in rural areas with 16.5% achieving healthy aging. In 2011, rural residents had a higher fall incidence rate (17% in rural vs. 13.5% in urban); by 2020, the fall rate remained higher in rural areas (19.5% in rural vs. 17.3% in urban). Unhealthy aging (HR = 1.08, 95%CI: 1.00–1.16) were risk factors for falls. Subgroup analysis revealed that in rural areas, unhealthy aging increased the risk of falls. In urban areas, the increased risk of falls associated with unhealthy aging was not significant (Rural HR = 1.11, 95%CI:1.01–1.22; Urban HR = 1.05, 95%CI: 0.93–1.18).ConclusionHealthy aging may be more strongly associated with a lower risk of falls in rural areas, while this association might be less pronounced in urban areas due to different environmental and social factors. This highlights the need for environment-specific fall prevention strategies and targeted measures for the older adult.
Chronic pain after traumatic brain injury: a collaborative care approach
Authors: Curran Mary C. , Lucas Sylvia , Fann Jesse R. , Zumsteg Jennifer M. , Hoffman Jeanne M. 
Published: August 2024

IntroductionChronic pain is common after traumatic brain injury (TBI), frequently limits daily activities, and is associated with negative outcomes such as decreased community participation. Despite the negative impact of chronic pain, few people with TBI receive effective treatment. This paper describes a collaborative care (CC) intervention, TBI Care, adapted specifically to treat chronic pain in people living with TBI, emphasizing expert clinician input, cognitive behavioral therapy (CBT) techniques, and other non-pharmacological approaches for decreasing pain interference.Methods79 participants engaged in the CC intervention from two academic medical rehabilitation clinics with weekly assessments of pain intensity, interference, and medication use. Participant feedback on the intervention was gathered by interview with the care manager (CM) at the last treatment session and/or booster session. Provider feedback was gathered by a confidential survey post intervention.ResultsNinety percent of participants received at least 11 of the target 12 sessions with a care manager (CM), the majority occurring over the phone. Participants endorsed an average of 7 pain locations. All participants received pain education, skills in self-monitoring, goal setting/behavioral activation and relaxation training. Pain interference scores (impact on activity and enjoyment), tracked weekly by the CM, significantly decreased across sessions. 89% of participants received recommendations for CBT skills, 65% received referrals for additional treatments targeting pain interference, and 43% received care coordination. 75% of participants reported 6 or more medications/supplements at both the first and last session, with changes recommended primarily for headache treatment. Feedback from participants and providers was positive.DiscussionTBI Care, a novel patient-centered CC approach, was flexibly delivered, tailored to the needs of those living with TBI and chronic pain, with a high level of participant engagement, and satisfaction among participants and providers. This approach, prioritizing pain self-management strategies and other non-pharmacological approaches, along with optimizing pharmacological treatment, led to significant reductions in self-reported pain interference and intensity during the intervention. Using a CC model in TBI is feasible and successfully improved access to evidence-based treatments for chronic pain as well as outcomes for pain interference and intensity.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT03523923.
Effects of silver diammine fluoride with/without potassium iodide on enamel and dentin carious lesions in primary teeth
Authors: Kaur M. , Anderson P. , Shahid S. , Davis G. R. , Mills D. , Wong F. S. L. 
Published: August 2024

AimTo assess the effects of SDF and SDF+KI treatment on enamel and dentin carious lesions in primary teeth using x-ray Microtomography (XMT) and back scattered scanning electron microscopy (BSE-SEM).MethodsArtificial enamel caries of 3 caries free primary teeth were created by immersion of the samples in 50 ml demineralization solution for 72 h. Three other teeth with natural dentin caries were selected. Both groups were divided into 3 subgroups: EC–Enamel Control; ES–Enamel with SDF application; ESK–Enamel with SDF followed by KI application; DC–Dentin Control; DS–Dentin with SDF application; DSK–Dentin with SDF followed by KI application. Each tooth was imaged using XMT at 3 time points: (1) Pretreatment; (2) after immersion in remineralization solution for 120 h, with or without SDF or SDF+KI; (3) after subsequent immersion in demineralization solution for 72 h. The change of radiopacities of the lesions in these time points were assessed from the XMT images. After the XMT scans, all teeth were investigated microscopically using BSE-SEM.ResultsIn EC, no change in linear attenuation coefficient (LAC) was observed after remineralization, but LAC reduction was observed after subsequent demineralization. For ES, thin layer of high LAC material was deposited on the enamel surface after remineralization, and further reduction of LAC was observed after demineralization. In ESK, the surface layer was lost after SDF+KI, and small reduction of LAC was observed after demineralization. In DC, no LAC change was observed after remineralization, but reduction of LAC was detected after demineralization. In DS, high LAC material was formed on the carious dentin surface and randomly inside the lesion. No further LAC change was found after demineralization. In DSK, thick layer of high LAC material was deposited on the carious surface and inside the dentinal tubules. No further LAC reduction was found after subsequent demineralization.ConclusionSDF and SDF+KI did not protect artificial enamel under acid attack even though Ag products were deposited in the porous enamel. However, SDF and SDF+KI shows protective properties against acid challenges and Ag products are deposited in carious dentin lesion without tubular structure randomly; and within dentinal tubules when these structures are retained.
Large anterior congenital urethral diverticulum in an infant: a case report
Authors: Hassan Mohammed A. , Bapir Rawa , Aghaways Ismaeil , Hama Nali H. , Raheem Mohammed Fahad , Sabr Wirya N. , Mohammed Bilal A. , Kareem Honar Othman , Mustafa Ayman M. , Kakamad Fahmi H. 
Published: August 2024

IntroductionA Urethral diverticulum can be defined as sac-like dilation lined with epithelial tissue, which may be congenital or acquired. It usually develops in the penoscrotal angle region but can also be observed in the penile urethra. It usually occurs in female teenagers. This report aims to discuss a male infant with a large urethral diverticulum.Case presentationA 5-month-old male presented to the urological department at Sulaimani Teaching Hospital with a penile swelling that had been noticeable since birth. Clinical examination revealed a ventral cystic penile shaft swelling, which would fill with fluid during urination. A urethrocystoscopy was performed and showed a wide cystic ventral diverticulum. Diverticulectomy was performed as a surgical approach to remove the diverticulum.DiscussionCongenital anterior urethral diverticulum is an uncommon condition that typically begins in early life. It can manifest with various symptoms, like recurrent infections of the urinary tract, painful urination, and post-void urine dribbling. Diagnosis involves imaging, with urethrocystoscopy, to rule out other potential diagnoses. Different surgical techniques exist that show promising results in preventing recurrence. The current case involved diverticulectomy and multi-layered wound closure with a dartos flap.ConclusionLarge anterior diverticulum in early infancy is rare but possible; operation is the preferred intervention method.