bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence to a Mediterranean-style diet and severity of menopausal symptoms in perimenopausal and menopausal women from Australia: a cross-sectional analysis
Authors: Byrne-Kirk Maitilde , Mantzioris Evangeline , Scannell Nicole , Villani Anthony 
Published: July 2024

Abstract
Purpose
To explore the independent associations between adherence to a Mediterranean-style diet and severity of menopausal symptoms in perimenopausal and menopausal women living in Australia.

Methods
Dietary adherence was assessed using the Mediterranean Diet Adherence Screener (MEDAS), the Menopause Rating Scale (MRS) was used to assess the severity of menopausal symptoms, and the 36-item short form survey instrument (SF-36) was used to assess health-related quality of life (HRQoL).

Results
A total of n = 207 participants (50.7 ± 4.3 years; BMI: 28.0 ± 7.4 kg/m2) were included in the final analyses. Participants reported low-moderate adherence to a Mediterranean-style diet (5.2 ± 1.8; range: 1–11). Adherence was not associated with severity of menopausal symptoms. However, low consumption of sugar-sweetened beverages was inversely associated with joint and muscle complaints, independent of all covariates (β = -0.149; CI: -0.118, -0.022; P = 0.042). Adherence to a Mediterranean-style diet was positively associated with the physical function subscale of HRQoL (β = 0.173, CI: 0.001, 0.029; P = 0.031) and a low intake of red and processed meat was positively associated with the general health subscale (β = 0.296, CI: 0.005, 0.014; P = < 0.001).

Conclusion
Diet quality may be related to severity of menopausal symptoms and HRQoL in perimenopausal and menopausal women. However, exploration of these findings using longitudinal analyses and robust clinical trials are needed to better elucidate these findings.
Glottic insufficiency caused by vocal fold atrophy with or without sulcus: systematic review of outcome measurements
Authors: van den Broek Emke M. J. M. , Mes Stephanie D. , Heijnen Bas J. , Langeveld Antonius P. M. , van Benthem Peter Paul G. , Sjögren Elisabeth V. 
Published: July 2024

Abstract
Purpose
Identifying outcome measurements instruments (OMIs) to evaluate treatment efficacy in patients with vocal fold atrophy and/or sulcus.

Methods
Systematic review of records published before March 2021 by searching Pubmed and EMBASE. Included studies reported on adults (> 18 year) with dysphonia caused by glottic insufficiency due to vocal fold atrophy with or without sulcus, who were enrolled into a randomized controlled trial, a non-randomized controlled trial, a case-controlled study or a cohort study. All included studies described an intervention with at least one outcome measurement.

Results
A total of 5456 studies were identified. After removing duplicates, screening title and abstract and full text screening of selected records, 34 publications were included in final analysis. From these 50 separate OMIs were recorded and categorized according to the ELS protocol by DeJonckere et al. (Eur Arch Otorhinolaryngol 258: 77–82, 2001). With most OMIs being used in multiple studies the total number of OMIs reported was 265. Nineteen (19) individual OMIs accounted for 80% of reports. The most frequently used OMIs according to category were: VHI and VHI-10 (subjective evaluation); G of GRBAS (perceptual evaluation); F0, Jitter and Shimmer (acoustic evaluation); MPT and MFR (aerodynamic evaluation) and glottic closure and mucosal wave (endoscopic evaluation). Of these OMIs VHI had a high percentage of significance of 90%.

Conclusion
This systematic review identifies the most used OMIs in patients with glottic incompetency due to vocal fold atrophy and/or sulcus as a step toward defining a Core Outcome Set (COS) for this population.

PROSPERO registration
238274.
Endoscopic vacuum therapy (eVAC) combined with continuous perianastomotic irrigation for prevention of anastomotic leak after surgical ampullectomy
Authors: Meier Olga , Ferrari Carlo , Ehrsam Jonas Peter , Porreca Annamaria , Seewald Stefan , Groth Stefan , Gutzwiller Jean-Pierre , Schmidt Jan 
Published: July 2024

Abstract
Purpose
Transduodenal surgical ampullectomy (tAMP) with papillary reimplantation is a valid alternative to pancreaticoduodenectomy for lesions of the periampullary region not amenable to endoscopic resection. As tAMP is burdened by high rates of biliopancreatic-enteric anastomotic leak, we tested preventive endoluminal vacuum therapy (eVAC) combined with post-operative continuous perianastomotic irrigation (CPI) to reduce such anastomotic leak.

Methods
Between 10/2013 and 09/2023, 37 patients undergoing laparotomic tAMP (with or without jejunal transposition) and papillary reimplantation at Hirslanden Klinik Zurich were retrospectively analysed; of these, 16 received prophylactic eVAC combined with CPI, while the remaining represented the historical cohort.

Results
The eVAC-CPI-group and the historical-cohort were homogeneous in demographic characteristics. Surgery in the prophylactic eVAC-CPI-group lasted about 30 min longer due to eVAC application (p = 0.008). The biliopancreatico-enteric anastomotic leak rates were 6.2% in the eVAC-CIP-group vs. 19.0% in the historical-cohort (p = 0.266). Along, a strong trend of less severe post-operative complications in general (p = 0.073), and borderline-significantly less cases of acute pancreatitis (p = 0.057) and tAMP-related re-operations or re-interventions (p = 0.057) in particular, were observed in the eVAC-CPI-group. The only anastomotic leak in the eVAC-CPI-group was successfully managed through repeated cycles of eVAC. The device was well tolerated by all patients; no vacuum/irrigation-related complications or malfunctioning occurred.

Conclusion
Our study is the first to provide some technical insights demonstrating the safety and feasibility of a prophylactic approach with eVAC and perianastomotic irrigation to reduce anastomotic leak after tAMP. Increasing the number of subjects will confirm the benefit of our promising results.
Giant cell carcinoma of the urinary bladder
Authors: Portugal-Gaspar Frederico , Lopez-Beltran Antonio , Paner Gladell P. , Blanca Ana , Gómez Enrique Gómez , Montironi Rodolfo , Cimadamore Alessia , Bilé Andreia , Volavšek Metka , Cheng Liang 
Published: July 2024

AbstractWe present the clinicopathological features of 23 cases of the giant cell subtype of urothelial carcinoma, a rare subtype of bladder cancer recognized in the current World Health Organization classification of urological tumors. Histologically, the architectural pattern of the tumor varied from infiltrating to the solid expansile pleomorphic tumor with giant, bizarre, anaplastic cells. Typical or atypical mitotic figures were frequently present in all cases. Between 10 and 30% of the tumor had a giant cell component. All cases were associated with conventional high-grade urothelial carcinoma, with areas of squamous cell divergent differentiation and micropapillary carcinoma present in six and two cases, respectively. In one case each had sarcomatoid, nested, small cell, or glandular divergent differentiation. At diagnosis, 35% of patients had advanced disease and 12% had distant metastases. When comparing giant cell urothelial carcinoma with conventional urothelial carcinoma in a matched analysis, differences in overall and cancer-specific survival were observed, particularly in the T1 stage category. Immunohistochemical staining showed a similar profile of urothelial lineage with frequent positive expression of uroplakin II, GATA3, CK20, CK7, and S100P in both giant cell and conventional urothelial carcinomas. High Ki67 proliferation (range, 60–90%; mean, 71%) and nuclear p53 accumulation (mutant profile; range, 50–90%; mean, 64%) were observed. Using the 22C3 assay, the expression of PD-L1 was found to be variable in two cases, and beta-HCG was negative. In conclusion, giant cell carcinoma is a subtype of urothelial carcinoma associated with advanced clinical stage and a trend to lower survival rates.
Trans‑anal minimally invasive surgery (TAMIS) versus rigid platforms for local excision of early rectal cancer: a systematic review and meta-analysis of the literature
Authors: Garoufalia Zoe , Rogers Peter , Meknarit Sarinya , Mavrantonis Sofoklis , Aeschbacher Pauline , Ray-Offor Emeka , Emile Sameh Hany , Gefen Rachel , Dourado Justin , Horesh Nir , Wexner Steven D. 
Published: July 2024

Abstract
Background
Available platforms for local excision (LE) of early rectal cancer are rigid or flexible [trans‑anal minimally invasive surgery (TAMIS)]. We systematically searched the literature to compare outcomes between platforms.

Methods
PRISMA-compliant search of PubMed and Scopus databases until September 2022 was undertaken in this random-effect meta-analysis. Statistical heterogeneity was assessed using I2 statistic. Studies comparing TAMIS versus rigid platforms for LE for early rectal cancer were included. Main outcome measures were intraoperative and short-term postoperative outcomes and specimen quality.

Results
7 studies were published between 2015 and 2022, including 931 patients (423 females); 402 underwent TAMIS and 529 underwent LE with rigid platforms. Techniques were similar for operative time (WMD 11.1, 95%CI − 2.6 to 25, p = 0.11), percentage of defect closure (OR 0.7, 95%CI 0.06–8.22, p = 0.78), and peritoneal violation (OR 0.41, 95%CI 0.12–1.43, p = 0.16). Rigid platforms had higher rates of short-term complications (19.1% vs 14.2, OR 1.6, 95%CI 1.07–2.4, p = 0.02), although no significant differences were seen for major complications (OR 1.41, 95%CI 0.61–3.23, p = 0.41). Patients in the rigid platforms group were 3-times more likely to be re-admitted within 30 days compared to the TAMIS group (OR 3.1, 95%CI 1.07–9.4, p = 0.03). Rates of positive resection margins (rigid platforms: 7.6% vs TAMIS: 9.34%, OR 0.81, 95%CI 0.42–1.55, p = 0.53) and specimen fragmentation (rigid platforms: 3.3% vs TAMIS: 4.4%, OR 0.74, 95%CI 0.33–1.64, p = 0.46) were similar between the groups. Salvage surgery was required in 5.5% of rigid platform patients and 6.2% of TAMIS patients (OR 0.8, 95%CI 0.4–1.8, p = 0.7).

Conclusion
TAMIS or rigid platforms for LE seem to have similar operative outcomes and specimen quality. The TAMIS group demonstrated lower readmission and overall complication rates but did not significantly differ for major complications. The choice of platform should be based on availability, cost, and surgeon’s preference.
Factors influencing circuit lifetime in paediatric continuous kidney replacement therapies – results from the EurAKId registry
Authors: Deja Anna , Guzzo Isabella , Cappoli Andrea , Labbadia Raffaella , Bayazit Aysun Karabay , Yildizdas Dincer , Schmitt Claus Peter , Tkaczyk Marcin , Cvetkovic Mirjana , Kostic Mirjana , Hayes Wesley , Shroff Rukshana , Jankauskiene Augustina , Virsilas Ernestas , Longo Germana , Vidal Enrico , Mir Sevgi , Bulut Ipek Kaplan , Pasini Andrea , Paglialonga Fabio , Montini Giovanni , Yilmaz Ebru , Correia Costa Liane , Teixeira Ana , Schaefer Franz ,   for the ESCAPE Network
Published: July 2024

Abstract
Background
Continuous kidney replacement therapy (CKRT) has recently become the preferred kidney replacement modality for children with acute kidney injury (AKI). We hypothesise that CKRT technical parameters and treatment settings in addition to the clinical characteristics of patients may influence the circuit lifetime in children.

Methods
The study involved children included in the EurAKId registry (NCT 02960867), who underwent CKRT treatment. We analysed patient characteristics and CKRT parameters. The primary end point was mean circuit lifetime (MCL). Secondary end points were number of elective circuit changes and occurrence of dialysis-related complications.

Results
The analysis was composed of 247 children who underwent 37,562 h of CKRT (median 78, IQR 37–165 h per patient). A total of 1357 circuits were utilised (3, IQR 2–6 per patient). MCL was longer in regional citrate anticoagulation (RCA), compared to heparin (HA) and no anticoagulation (NA) (42, IQR 32-58 h; 24, IQR 14-34 h; 18, IQR 12-24 h, respectively, p < 0.001). RCA was associated with longer MCL regardless of the patient’s age or dialyser surface. In multivariate analysis, MCL correlated with dialyser surface area (beta = 0.14, p = 0.016), left internal jugular vein vascular access site (beta = -0.37, p = 0.027), and the use of HA (beta = -0.14, p = 0.038) or NA (beta = -0.37, p < 0.001) vs. RCA. RCA was associated with the highest ratio of elective circuit changes and the lowest incidence of complications.

Conclusion
Anticoagulation modality, dialyser surface, and vascular access site influence MCL. RCA should be considered when choosing first-line anticoagulation for CKRT in children. Further efforts should focus on developing guidelines and clinical practice recommendations for paediatric CKRT.

Graphical abstract
Volatile organic compounds and cancer risk assessment in an intensive care unit
Authors: Lakestani Sanaz 
Published: July 2024

AbstractChanges caused by air-cleaning devices in the amounts of volatile organic compounds in an intensive care unit were monitored in the study. The cancer risk and hazard index were calculated. The measurements were made for one month at isolated room and two different points and times in the intensive care unit. According to the sampling program, the air-cleaning devices were turned off in weeks 1 and 4 and turned on in weeks 2 and 3. Volatile organic compounds were collected by active sampling. Samples were analyzed by a thermal desorber coupled to a gas chromatography-mass spectrometry instrument with selective ion monitoring. The results showed that the concentrations of benzene, toluene, and o-xylene decreased by about 70% after the air-cleaning devices were installed. The cancer risk assessment for naphthalene was recorded at the highest level of cancer risk (Class A). The hazard index value of naphthalene was recorded at the harmful level when air-cleaning devices were not installed. The concentrations of benzene (p = 0.01), toluene (p = 0.02), ethylbenzene (p = 0.02), styrene (p = 0.01), and m, p-xylene (p = 0.04) before the air-cleaning devices were installed were significantly different from those recorded when the air-cleaning devices were turned on.
Marmorgewinnung und Schmiedetätigkeit im Frühmittelalter – Ein erster Hinweis im Steinbruchrevier Spitzelofen in Kärnten/Österreich
Authors: Karl Stephan , Modl Daniel , Strobl Susanne , Haubner Roland 
Published: July 2024

ZusammenfassungIm römerzeitlichen Marmorsteinbruchrevier Spitzelofen in Kärnten wurde bei archäologischen Ausgrabungen auch Hammerschlag gefunden, der aus einer frühmittelalterlichen Brandschicht stammt. Radiokarbondatierungen dieser Schicht weisen den Befund in das 8. bzw. 9. Jahrhundert n. Chr. Im Zuge der metallurgischen Untersuchung wurde plättchenförmiger Hammerschlag festgestellt. Die Dicke der Plättchen variiert zwischen etwa 30 und 100 µm. Es kann davon ausgegangen werden, dass diese Plättchen durch Verzunderung während des Schmiedevorgangs entstanden. Weiters wurde kugelförmiger Hammerschlag beobachtet, bei dem es sich um ein Gemisch aus geschmolzenem Eisen und Schlacke handelt, das beim Hochtemperaturschmieden (> 1200 °C) vom Werkstück wegspritzt. Diese Teilchen haben einen Durchmesser von etwa 250 µm. Der archäologische Kontext, der Hammerschlag und die Radiokarbondatierungen belegen eine mit der Marmorgewinnung zusammenhängende Schmiedetätigkeit im 8. und 9. Jahrhundert n. Chr. In einer einfachen Feldschmiede wurden die durch die Benutzung stumpf gewordenen Steinbruchwerkzeuge nachgeschärft. Dieser somit indirekt gewonnene Nachweis einer frühmittelalterlichen Steingewinnung am Spitzelofen deckt sich zeitlich mit der Marmorverwendung für die frühmittelalterlichen Flechtwerksteine in Karantanien (772 bis 817/828 n. Chr.).
Ab initio MO study on direct production of H2O, N2O and CO3 from the respective CH2OO “Bee-sting-like” attack at H2, N2 and CO2
Authors: Trac Hue-Phuong , Lin Ming-Chang 
Published: July 2024

Abstract
Context
We have computationally elucidated the mechanism for formation of H2O, N2O and CO3 from the reactions of CH2OO with H2, N2 and CO2, respectively, by the direct attack of the terminal O atom of CH2OO. This unique mechanism, which is characteristically “bee-sting-like” in nature, was found to be closely parallel to their reactions with the O(1D) atom. Reactions with H2 and CO2 take place by side-on attack, while the N2 reaction occurs by end-on attack with predicted barriers, 19.4, 13.1 and 25.3 kcal.mol−1, respectively. The CO2 reaction with CH2OO was found to occur by producing the C2v CO3, O = C < (O)O, instead of its D3h conformer, essentially similar to the O(1D) + CO2 reaction. The rate constants for the three reactions have been computed by the transition state theory (TST) based on the predicted potential energy profiles. We have also utilized the isodesmic nature of the dative bond exchange in the N2 reaction, CH2O → O + N2 = CH2O + N2 → O, to estimate the heat of the formation of CH2OO. Based on the heat of reaction computed at the highest level of theory employed, we obtained ΔfHo0 (CH2OO) = 27.5 kcal.mol−1; the value agrees with the recent results within ± 1 kcal.mol−1.

Methods
All calculations were performed using Gaussian 16 software. Geometry, frequency, and IRC analysis calculations were conducted at the M06-2X/aug-cc-pVTZ level of theory. The heats of reaction have been evaluated at the highest level, CCSD(T)/CBS(T,Q,5)//M06-2x/aug-cc-pvTz.
Towards overcoming barriers to the clinical deployment of mixed reality image-guided navigation systems supporting percutaneous ablation of liver focal lesions
Authors: Spinczyk Dominik , Rosiak Grzegorz , Milczarek Krzysztof , Konecki Dariusz , Żyłkowski Jarosław , Franke Jakub , Pech Maciej , Rohmer Karl , Zaczkowski Karol , Wolińska-Sołtys Ania , Sperka Piotr , Hajda Dawid , Piętka Ewa 
Published: July 2024

AbstractIn recent years, we have observed a rise in the popularity of minimally invasive procedures for treating liver tumours, with percutaneous thermoablation being one of them, conducted using image-guided navigation systems with mixed reality technology. However, the application of this method requires adequate training in using the employed system. In our study, we assessed which skills pose the greatest challenges in performing such procedures. The article proposes a training module characterized by an innovative approach: the possibility of practicing the diagnosis, planning, execution stages and the physical possibility of performing the execution stage on the radiological phantom of the abdominal cavity. The proposed approach was evaluated by designing a set of 4 exercises corresponding to the 3 phases mentioned. To the research group included 10 radiologists and 5 residents in the study. Based on 20 clinical cases of liver tumors subjected to percutaneous thermoablation, we developed assessment tasks evaluating four skill categories: head-mounted display (HMD), ultrasound (US)/computed tomography (CT) image fusion interpretation, tracking system use, and the ability to insert a needle. The results were presented using the Likert scale. The results of our study indicate that the most challenging aspect for radiology specialists is adapting to HMD gesture control, while residents point to intraoperative images of fusion and respiratory movements in the liver as the most problematic. In terms of improving the ability to perform procedures on new patients, the module also allows you to create a new hologram for a different clinical case.
Environmental impact of the variations in solar reflectance index values of some selected dimension stones due to cyclic thermal shock
Authors: Altindag Rasit , Ugur Ibrahim , Sengun Nazmi , Coskun Ahmet , Demirdag Servet 
Published: July 2024

AbstractNatural stones are widely used environmentally appropriate building materials as dimension stone both for exterior cladding and floor coverings in urban areas. Depending on their solar reflectivity, these materials may absorb more solar radiation, especially with noontime summer sunlight exposure, which may cause both increasing cooling costs in commercial buildings and overheating of a city with the formation of urban heat islands. Solar reflectance index (SRI) is defined as the ability of a surface to reject solar heat which tends to change with physical, chemical and biological degradation processes by varying solar reflectance (SR) and thermal emissivity (TE) values. Weakening of the stone matrix structure by physical degradation mechanism, such as thermal shock (T-S) cycles mostly have significant impact on SRI. Within the scope of this study, SRI values were calculated before and after cyclic T-S by measuring the optical properties such as SR and TE values of 30 selected sedimentary and metamorphic originated carbonate-based natural stone types. The changes in surface properties such as color, roughness, and gloss, that may have an impact on the SRI values were also analyzed. In addition, a multivariate regression analysis was established to predict SRI value from such properties with a high degree of accuracy. Finally, it was found that, initial SRI values of 9 natural stone types (mostly metamorphic originated) have been increased considerably by cyclic T-S and tend to increase their ability to reduce urban temperatures by higher SRI values, one of the most important selection criteria in energy consumption for natural stones.
Levodopa-responsive dystonia, parkinsonism, and treatment-resistant schizoaffective disorder in Williams syndrome
Authors: Reyes Nikolai Gil D. , Bendahan Nathaniel , Swinkin Emily , Lang Anthony E. , Bassett Anne S. 
Published: July 2024

Abstract
Background
Williams syndrome (WS; chromosome 7q11.23 deletion) is a rare, multisystemic, neurodevelopmental disorder with variable penetrance and expressivity. Although movement and psychiatric disorders are known to occur in individuals with WS, parkinsonism, dystonia, and treatment-resistant schizoaffective disorder have not been formally described.

Methods
We present two unrelated cases of adults with molecularly confirmed WS and typical histories of developmental delays, intellectual/learning disabilities, and treatment-responsive anxiety/mood disorder who developed similar noteworthy neuropsychiatric expressions. We reviewed detailed neuropsychiatric histories, laboratory investigations, neuroimaging, and treatment responses and compared data for the two cases.

Results
Both individuals developed treatment-resistant schizoaffective disorder in adulthood requiring multiple trials of antipsychotic treatments. While on clozapine, both patients developed parkinsonism and generalized dystonia with truncal involvement that responded to trials of low-dose levodopa without exacerbating underlying psychotic or affective symptoms.

Conclusion
This report illustrates the novel occurrence of levodopa-responsive movement disorders and treatment-resistant schizoaffective disorder in individuals with WS, adding to the expanding neuropsychiatric phenotypes, and highlighting potential shared underlying mechanisms. The observed treatment response suggests that levodopa, in relatively low doses, may be safe and useful in ameliorating presumed antipsychotic-associated parkinsonism and tardive dystonia in WS.