bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A General Pd‐Catalyzed Decarboxylative Cross‐Coupling Reaction Between Aryl Carboxylic Acids: Synthesis of Biaryl Compounds.
Authors: Hu Peng , Shang Yaping , Su Weiping 
Published: October 2012

AbstractThe use of a Pd(II)/PCy3 catalyst enables the cross‐coupling of electronically different or electronically similar aryl carboxylic acids.
ChemInform Abstract: Cyclopalladated Ferrocenylimine as an Efficient Catalyst for the Syntheses of Diarylmethane Derivatives.
Authors: Yu Ajuan , Li Xiangdong , Peng Dongpo , Wu Yangjie , Chang Junbiao 
Published: October 2012

AbstractThe Suzuki cross‐coupling tolerates various functional groups using a highly active catalyst.
ChemInform Abstract: Palladium‐Catalyzed Direct C—H Arylation of Enamides with Simple Arenes.
Authors: Pankajakshan Sreekumar , Xu Yun‐He , Cheng Jun Kee , Low Man Ting , Loh Teck‐Peng 
Published: October 2012

AbstractThe presented direct arylation reaction of enamides (I) with simple arenes proceeds with absolute Z‐selectivity.
ChemInform Abstract: Rhodium(II)‐Catalyzed Cyclization of Bis(N‐tosylhydrazone)s: An Efficient Approach Towards Polycyclic Aromatic Compounds.
Authors: Xia Ying , Liu Zhenxing , Xiao Qing , Qu Peiyuan , Ge Rui , Zhang Yan , Wang Jianbo 
Published: October 2012

AbstractA general approach towards polycyclic aromatic compounds is presented, involving the Rh‐catalyzed cyclization of bis(tosylhydrazones), e.g. (I).
ChemInform Abstract: Synthesis of Some Heterocyclic Compounds from Enamines of 3‐Acetylfuran‐2(5H)‐ones.
Authors: Melikyan Gagik S. , Hovhannisyan Anna A. , Hayotsyan Sargis S. 
Published: October 2012

AbstractThe reaction of 4‐methyl‐3‐acetylfuranone with acetal (II) and aldehyde (V) proceeds regioselectively at the 4‐methyl group to afford enamines (III) and (VI) leaving the acetyl group intact.
ChemInform Abstract: Phosphine/Palladium‐Catalyzed Syntheses of Alkylidene Phthalans, 3‐Deoxyisoochracinic Acid, Isoochracinic Acid, and Isoochracinol.
Authors: Fan Yi Chiao , Kwon Ohyun 
Published: October 2012

AbstractSmall amounts of (E)‐isomers are also formed but their purification and isolation is difficult.
ChemInform Abstract: Rhodium‐Catalyzed Intramolecular Cyclization of Naphthol‐ or Phenol‐Linked 1,6‐Enynes Through the Cleavage and Formation of sp2 C—O Bonds.
Authors: Sakiyama Norifumi , Noguchi Keiichi , Tanaka Ken 
Published: October 2012

AbstractThe method produces vinylnaphtho‐ or vinylbenzofurans and vinylnaphtho‐ or vinylbenzopyrans.
ChemInform Abstract: Thieno[3,2‐b]thiophene‐2‐carboxylic Acid Derivatives as GPR35 Agonists.
Authors: Deng Huayun , Hu Jieyu , Hu Haibei , He Mingqian , Fang Ye 
Published: October 2012

AbstractThe title derivatives are obtained from dibromo‐ and perbromothiophene (I) and (XIII) via a ketone‐based ring closure reaction and subsequent introduction of substituents into the thienothiophene core by Hiyama or Suzuki cross‐coupling.
ChemInform Abstract: Dithiolane‐Directed Tandem Oxidation/1,2‐Benzyl Migration of Tetramic Acids under Ambient Conditions.
Authors: Li Yifei , Xu Xianxiu , Xia Chunyu , Pan Ling , Liu Qun 
Published: October 2012

AbstractSuccinimide derivatives (II) are efficiently synthesized by the new method.
ChemInform Abstract: Approach to the Synthesis of Indoline Derivatives from Diaryliodonium Salts.
Authors: Landge Kamalkishor P. , Jang Keun Sam , Lee Sang Yeul , Chi Dae Yoon 
Published: October 2012

AbstractThe novel method is based on the metal‐free intramolecular nucleophilic ring closing of diaryliodonium salts such as (I).
ChemInform Abstract: Highly Regio‐ and Stereoselective Dirhodium Vinylcarbene Induced Nitrone Cycloaddition with Subsequent Cascade Carbenoid Aromatic Cycloaddition/N—O Cleavage and Rearrangement.
Authors: Wang Xiaochen , Abrahams Quentin M. , Zavalij Peter Y. , Doyle Michael P. 
Published: October 2012

AbstractThe cascade involves a metal carbene induced regioselective [3 + 2] cycloaddition, a Buchner reaction, and a [1,7]‐oxygen migration, which occurs with N—O cleavage.
ChemInform Abstract: RuH2(CO)(PPh3)3 Catalyzed Selective Formation of 1,4‐Disubstituted Triazoles from Cycloaddition of Alkynes and Organic Azides.
Authors: Liu Pei Nian , Siyang Hai Xiao , Zhang Li , Tse Sunny Kai San , Jia Guochen 
Published: October 2012

AbstractIn addition to the cycloaddition reactions of terminal alkynes with aromatic or aliphatic azides (18 examples), alcohol (VII) is formed by both cycloaddition and transfer hydrogenation reactions in the presence of 1,4‐butanediol and the ruthenium catalyst.
ChemInform Abstract: One‐Pot Three‐Component Click Reaction of Cyclic Sulfates and Cyclic Sulfamidates.
Authors: Megia‐Fernandez Alicia , Ortega‐Munoz Mariano , Hernandez‐Mateo Fernando , Santoyo‐Gonzalez Francisco 
Published: October 2012

AbstractAlkyl sulfate triazoles (III) and (V) are efficiently synthesized by the reaction of cyclic sulfates (I) with aliphatic and aromatic terminal alkynes (II) and sodium azide under microwave irradiation.
ChemInform Abstract: Synthesis of 5‐(4‐Aminophenyl)‐2‐(arylamino)‐1,3,4‐thiadiazoles and Their Schiff Base Derivatives as Antimycobacterial Agents.
Authors: Dilmaghani K. A. , Jazani N. H. , Pur F. Nasuhi , Shokoufeh N. , Ghadiri F. , Fakhraee F. M. 
Published: October 2012

AbstractTitle thiadiazoles (II) and their Schiff base derivatives (IV) (12 examples) show significant antiproliferative activities against Mycobacterium smegmatis PTCC 1307.
ChemInform Abstract: Synthesis of 3‐Iodopyrrolocoumarins via Iodine‐Induced 5‐endo‐dig Electrophilic Cyclization
Authors: Majumdar K. C. , De Nirupam , Sinha Biswajit , Roy B. 
Published: October 2012

Abstractof 5‐alkynyl‐6‐tosylaminocoumarin derivatives (IV)
ChemInform Abstract: Organocatalytic Asymmetric Domino Sulfa‐Michael—Aldol Reactions of 2‐Mercaptobenzaldehyde with α,β‐Unsaturated N‐Acylpyrazoles for the Construction of Thiochromane.
Authors: Dong Xiu‐Qin , Fang Xin , Tao Hai‐Yan , Zhou Xiang , Wang Chun‐Jiang 
Published: October 2012

AbstractThe pivotal key is the introduction of the pyrazole moiety as H‐bond acceptor, which allows for better organization and activation.
ChemInform Abstract: Synthesis and Evaluation of Pyridylbenzofuran, Pyridylbenzothiazole and Pyridylbenzoxazole Derivatives as 18F‐PET Imaging Agents for β‐Amyloid Plaques.
Authors: Swahn Britt‐Marie , et al. et al. 
Published: October 2012

AbstractThe synthesis of 17 title compounds of type (I), (II), or (III) is outlined.
ChemInform Abstract: A CuAAC/Ullmann C—C Coupling Tandem Reaction: Copper‐Catalyzed Reactions of Organic Azides with N‐(2‐Iodoaryl)propiolamides or 2‐Iodo‐N‐(prop‐2‐ynyl)benzenamines.
Authors: Cai Qian , Yan Jiajie , Ding Ke 
Published: October 2012

AbstractThe sequence allow a new and efficient access to a number of triazoloquinoline derivatives.
ChemInform Abstract: Ethyl 5‐Amino‐3‐oxo‐1,2‐dihydro‐1H‐pyrazole‐1‐carboxylate in the Selective Synthesis of Partially Hydrogenated Pyrazolo[3,4‐b]pyridin‐3‐ones.
Authors: Lebed P. S. , Mozgovaya N. G. , Kos P. O. , Vovk M. V. 
Published: October 2012

AbstractReaction of the title pyrazole‐1‐carboxylate (I) with 1,3‐dicarbonyl compounds or their synthetic equivalents provides a general, regiospecific synthetic route to dihydrapyrazolopyridinones.
ChemInform Abstract: RhII2‐Catalyzed Synthesis of α‐, β‐, or δ‐Carbolines from Aryl Azides.
Authors: Pumphrey Ashley L. , Dong Huijun , Driver Tom G. 
Published: October 2012

AbstractThe reaction proceeds via carbolinium ions which are readily reduced to afford tryptolines or deprotonated to access pyridoindoles.
ChemInform Abstract: N—N Bond‐Forming Cyclization for the One‐Pot Synthesis of N‐Aryl[3,4‐d]pyrazolopyrimidines.
Authors: Evans Lindsay E. , Cheeseman Matthew D. , Jones Keith 
Published: October 2012

AbstractA new and efficient method to prepare biologically important pyrazolopyrimidines of type (III) is reported.
ChemInform Abstract: Regiodirected Synthesis of Polyfluoroalkylated Pyrimido[1,2‐a]benzimidazoles.
Authors: Goryaeva M. V. , Burgart Ya. V. , Saloutin V. I. , Chupakhin O. N. 
Published: October 2012

AbstractThe nature of the solvent used and the length of the fluoroalkyl‐substituent in 3‐oxo‐3‐polyfluoroalkyl‐2‐ethoxymethylidenepropionates prove to be the main features which determine the regioselectivity in the reaction of aminobenzimidazole (II) with the propionates mentioned above.
ChemInform Abstract: Rhodium(II)‐ and Copper(II)‐Catalyzed Reactions of Enol Diazoacetates with Nitrones: Metal Carbene versus Lewis Acid Directed Pathways.
Authors: Qian Yu , Xu Xinfang , Wang Xiaochen , Zavalij Peter J. , Hu Wenhao , Doyle Michael P. 
Published: October 2012

AbstractCopper(II) hexafluoroantimonate catalyzes the formal [3 + 3] cycloaddition of Lewis acid activated nitrones and vinyl diazoacetates to produce 1,2‐oxazines in high yields and diastereoselectivities.
ChemInform Abstract: Access to Functionalized 4‐Benzylidene‐4H‐benzo[d][1,3]thiazines via Tandem Addition‐Cyclization/Cross‐Coupling Reactions.
Authors: Ding Qiuping , Liu Xianjin , Yu Jinsheng , Zhang Qiulan , Wang Dan , Cao Banpeng , Peng Yiyuan 
Published: October 2012

AbstractA novel, mild, highly regiospecific, and efficient method for the synthesis of the title compounds is described from readily available starting materials.
ChemInform Abstract: Heterocycles. Part 27. Microwave‐Assisted Synthesis and Antitumor Activity of Novel Phenothiazinyl‐Thiazolyl‐Hydrazine Derivatives.
Authors: Ignat Adriana , Lovasz Tamas , Vasilescu Mihai , Fischer‐Fodor Eva , Tatomir Corina Bianca , Cristea Castelia , Silaghi‐Dumitrescu Luminita , Zaharia Valentin 
Published: October 2012

AbstractMicrowave‐assisted Hantzsch cyclization leads to novel phenothiazinyl‐thiazolyl‐hydrazine derivatives (III) which are evaluated for their antiproliferative effect against hepatic HepG2 tumor cells and colon carcinoma CC531S cells.
ChemInform Abstract: A Silver(I)‐Catalyzed Tandem Reaction of 2‐Alkynylbenzaldoxime with Alkylidenecyclopropane.
Authors: Xiao Qian , Ye Shengqing , Wu Jie 
Published: October 2012

AbstractThe reaction allows a new, unexpected formation of bridged multi‐membered N‐heterocycles.
ChemInform Abstract: Asymmetric Hydrogenation of 2,4‐Disubstituted 1,5‐Benzodiazepines Using Cationic Ruthenium Diamine Catalysts: An Unusual Achiral Counteranion Induced Reversal of Enantioselectivity.
Authors: Ding Zi‐Yuan , Chen Fei , Qin Jie , He Yan‐Mei , Fan Qing‐Hua 
Published: October 2012

AbstractTitle asymmetric hydrogenation reaction of disubstituted benzodiazepines (I) proceeds with excellent enantio‐ (90 to < 99% e.e.) and moderate to good diastereoselectivity (50 to < 90% d.e.) in the presence of a chiral Ru—diamine catalyst.
ChemInform Abstract: Stereoselective Synthesis of o‐Bromo (or Iodo)aryl P‐Chirogenic Phosphines Based on Aryne Chemistry.
Authors: Leroux Frederic R. , et al. et al. 
Published: October 2012

AbstractThe method is based on the reaction of a secondary phosphine borane with the aryne species formed in situ from 1,2‐dibromo‐ or 1,2‐diiodobenzene by treatment with BuLi.
ChemInform Abstract: Synthesis of Dialkyl 2‐(Dialkoxyphosphoryl)‐3‐(4‐oxo‐4,5‐dihydro‐thiazole‐2‐yl sulfanyl) Succinates.
Authors: Hassanabadi Alireza , Mosslemin Mohammad H. , Salari Shabnam , Landi Mahnoush Momeni 
Published: October 2012

AbstractThree‐component reaction of rhodanine (I) with DMAD (II) and triorganyl phosphites (III) provides access towards title phosphorylsuccinates (IV) in high yields.
ChemInform Abstract: A Scalable, Efficient Gold‐Catalyzed Oxidative Phosphonation of sp3 C—H Bonds Using Air as Sustainable Oxidant.
Authors: Xie Jin , Li Huamin , Xue Qicai , Cheng Yixiang , Zhu Chengjian 
Published: October 2012

AbstractThe method provides an easy access to α‐amino phosphonic compounds in good yields.
ChemInform Abstract: Formation of a Novel Heterocyclic System Based on Natural Alantolactone.
Authors: Klochkov S. G. , Afanas'eva S. V. , Pukhov S. A. 
Published: October 2012

AbstractReaction of 5α‐epoxyalantolactone (I), a secondary metabolite of the plant Inula L., with tryptamine derivatives (II) results in the stereospecific formation of the novel heterocyclic system, benzo[g]furoindolones (III).
ChemInform Abstract: Sentulic Acid: A Cytotoxic Ring A‐seco Triterpenoid from Sandoricum koetjape Merr.
Authors: Efdi Mai , Ninomiya Masayuki , Suryani Erma , Tanaka Kaori , Ibrahim Sanusi , Watanabe Kunitomo , Koketsu Mamoru 
Published: October 2012

AbstractMorphological studies and DNA fragmentation analysis show that the cytotoxic effects of title compound (I) are mediated by apoptosis.
ChemInform Abstract: Bioactive Briarane Diterpenoids from the South China Sea Gorgonian Dichotella gemmacea.
Authors: Li Cui , La Ming‐Ping , Tang Hua , Pan Wei‐Hua , Sun Peng , Krohn Karsten , Yi Yang‐Hua , Li Ling , Zhang Wen 
Published: October 2012

AbstractIsolation, structure elucidation and bioactivity of six new briarane diterpenoids, gemmacolides T—Y, are described.
ChemInform Abstract: Neamphamide B, New Cyclic Depsipeptide, as an Antidormant Mycobacterial Substance from a Japanese Marine Sponge of Neamphius sp.
Authors: Yamano Yoshi , Arai Masayoshi , Kobayashi Motomasa 
Published: October 2012

AbstractThe new cyclic depsipeptide neamphamide B is isolated from a marine sponge of Neamphius sp.
ChemInform Abstract: An Improved Protection‐Free One‐Pot Chemical Synthesis of 2′‐Deoxynucleoside‐5′‐triphosphates.
Authors: Kore Anilkumar R. , Shanmugasundaram Muthian , Senthilvelan Annamalai , Srinivasan Balasubramanian 
Published: October 2012

AbstractThis improved gram‐scale and Ludwig synthetic strategy involves monophosphorylation of the nucleoside followed by reaction of the intermediate dichlorophosphoridate with tributylammonium pyrophosphate.
ChemInform Abstract: Synthesis and Cytotoxic Activity of Novel 5‐Substituted‐1‐(β‐L‐arabinofuranosyl)pyrimidine Nucleosides.
Authors: Sendula Robert , Orban Erika , Hudecz Ferenc , Sagi Gyula , Jablonkai Istvan 
Published: October 2012

AbstractThe synthesis of unknown (L)‐nucleosides is accomplished with improved yields by applying benzoyl‐protected sugar derivatives instead of acetylated intermediates.
The Discovery of Stereoselectivity at Biological Receptors: Arnaldo Piutti and the Taste of the Asparagine Enantiomers—History and Analysis on the 125th Anniversary
Authors: Gal Joseph 
Published: October 2012

ABSTRACTIn 1886, Italian chemist Arnaldo Piutti isolated, for the first time, d‐asparagine, the enantiomer of the known l‐asparagine. He obtained 100 g of d‐asparagine from 6500 kg of vetches. Using an ingenious synthetic scheme, Piutti established the chemical structure of asparagine and demonstrated that his isolation of d‐asparagine from plants was not the result of the racemization of l‐asparagine during the extraction procedure. He found a striking difference in the taste of asparagine: l‐asparagine was without taste, while d‐asparagine was intensely sweet. This was the first example of enantioselectivity in a receptor‐mediated biological activity. Receptors constitute one of the most important and most intensively studied phenomena in biology, and enantioselectivity in receptor‐mediated activity, including at the sweetness receptor, is today an important and commonly seen aspect of receptor function. Therefore, Piutti's discovery, although made ca. 15 years before the emergence of the receptor concept, was a milestone. The publication of Piutti's asparagine work prompted several eminent scientists, including Louis Pasteur and Arthur Cushny, a leading pharmacologist of the time, to remark on the importance of the discovery. Piutti also carried out investigations in many other fields, e.g., other organic compounds and reactions, pharmaceuticals, alimentary products, radioactivity, noble gases, and spectroscopy. Considerable progress has been made in recent decades concerning the biology and chemistry of sweet taste, but the details of the interactions of chiral molecules with the sweetness receptor remain poorly understood. Piutti and his discovery are largely forgotten today; they deserve the attention of the chirality and receptor “communities.” Chirality 24:959–976, 2012. © 2012 Wiley Periodicals, Inc.
Dynamics of fluid flow and heat transfer in homogeneous porous media
Authors: Sajjadi M. , Azaiez J. 
Published: October 2012

AbstractNon‐isothermal miscible viscous flow in homogeneous porous media is studied through nonlinear simulation of the process and analysis of breakthrough efficiency. The main focus is on the effect of heat exchange between the displacing fluid and the solid matrix on the resulting instability. Higher diffusion rate of heat in the fluids reduces the effect of lagging between the fronts due to heat exchange. Hence, sweep efficiency of the injected solvent is less sensitive to thermal lag coefficient as the diffusion ratio increases. Variation of heat sweep efficiency with thermal lag coefficient and thermal log mobility ratio has been analysed as well. © 2012 Canadian Society for Chemical Engineering
Reducing thread divergence in a GPU‐accelerated branch‐and‐bound algorithm
Authors: Chakroun I. , Mezmaz M. , Melab N. , Bendjoudi A. 
Published: October 2012

SUMMARYIn this paper, we address the design and implementation of graphical processing unit (GPU)‐accelerated branch‐and‐bound algorithms (B&B) for solving flow‐shop scheduling optimization problems (FSP). Such applications are CPU‐time consuming and highly irregular. On the other hand, GPUs are massively multithreaded accelerators using the single instruction multiple data model at execution. A major issue that arises when executing on GPU, a B&B applied to FSP is thread or branch divergence. Such divergence is caused by the lower bound function of FSP that contains many irregular loops and conditional instructions. Our challenge is therefore to revisit the design and implementation of B&B applied to FSP dealing with thread divergence. Extensive experiments of the proposed approach have been carried out on well‐known FSP benchmarks using an Nvidia Tesla (C2050 GPU card (http://www.nvidia.com/docs/IO/43395/NV_DS_Tesla_C2050_C2070_jul10_lores.pdf)). Compared with a CPU‐based execution, accelerations up to × 77.46 are achieved for large problem instances. Copyright © 2012 John Wiley & Sons, Ltd.
Philopatry drives genetic differentiation in an island archipelago: comparative population genetics of Galapagos Nazca boobies (Sula granti) and great frigatebirds (Fregata minor)
Authors: Levin Iris I. , Parker Patricia G. 
Published: October 2012

AbstractSeabirds are considered highly mobile, able to fly great distances with few apparent barriers to dispersal. However, it is often the case that seabird populations exhibit strong population genetic structure despite their potential vagility. Here we show that Galapagos Nazca booby (Sula granti) populations are substantially differentiated, even within the small geographic scale of this archipelago. On the other hand, Galapagos great frigatebird (Fregata minor) populations do not show any genetic structure. We characterized the genetic differentiation by sampling five colonies of both species in the Galapagos archipelago and analyzing eight microsatellite loci and three mitochondrial genes. Using an F‐statistic approach on the multilocus data, we found significant differentiation between nearly all island pairs of Nazca booby populations and a Bayesian clustering analysis provided support for three distinct genetic clusters. Mitochondrial DNA showed less differentiation of Nazca booby colonies; only Nazca boobies from the island of Darwin were significantly differentiated from individuals throughout the rest of the archipelago. Great frigatebird populations showed little to no evidence for genetic differentiation at the same scale. Only two island pairs (Darwin – Wolf, N. Seymour – Wolf) were significantly differentiated using the multilocus data, and only two island pairs had statistically significant φST values (N. Seymour – Darwin, N. Seymour – Wolf) according to the mitochondrial data. There was no significant pattern of isolation by distance for either species calculated using both markers. Seven of the ten Nazca booby migration rates calculated between island pairs were in the south or southeast to north or northwest direction. The population differentiation found among Galapagos Nazca booby colonies, but not great frigatebird colonies, is most likely due to differences in natal and breeding philopatry.
A fecundity cost of (walking) mobility in an insect
Authors: Samietz Jörg , Köhler Günter 
Published: October 2012

AbstractEvolutionary theory predicts trade‐offs between fecundity and mobility, but there is substantial lack of empirical evidence if and how basic mobility relates to fitness costs. In a field experiment, we investigated fecundity costs of mobility in a non‐migratory, wing‐monomorphic grasshopper,Stenobothrus lineatus, and at the same time tested for possible effects of reproductive state (egg‐load) on the mobility. For 10 days, body weight and activity radius of 60 females were recorded daily and oviposition events were inferred from abrupt weight losses. We found a strong and significant relationship between the individual mobility and the time between egg pods laid (interpod period). Individual egg‐laying was reduced by a rate of 0.36 eggs per day with each meter increase in mean daily activity radius. The trade‐off was not biased by the size of the females, that is, constitution did not positively influence both offspring number and mobility. Egg‐load had no significant influence on the individual distances travelled. We could demonstrate that mobility – as induced and selected for by foraging, thermoregulation, predator escape, shelter seeking, and reproduction – can be directly paid off by fecundity. This direct consequence of mobility on individual fitness was detected for the first time in a walking insect.
Six decades of changes in the riparian corridor of a Mediterranean river: a synthetic analysis based on historical data sources
Authors: Garófano‐Gómez V. , Martínez‐Capel F. , Bertoldi W. , Gurnell A. , Estornell J. , Segura‐Beltrán F. 
Published: October 2012

ABSTRACTRiparian corridors in semi‐arid Mediterranean environments are ecosystems of high biodiversity and complexity. However, they are threatened because of high levels of human intervention. River damming and related flow manipulation is considered as one of the most prominent human impacts on riparian corridors. This study combines historical time series information on river flows and their human manipulation, historical aerial images depicting changes in riparian land cover and ground observations of the species – age composition and morphology of the riparian corridor of a Mediterranean river (the Mijares River, Eastern Spain) over the last 60 years. In this sense, we explored how to integrate information from a wide variety of data sources, and we extracted a variety of indices and undertook analyses that identified and summarized spatio‐temporal changes in riparian structure and in the driving flow processes. Results revealed an increase in the cover and density of woody vegetation and a decrease in bare sediment areas (essential for recruitment of riparian pioneer species), with a synchronous reduction in the complexity of the riparian corridor of the middle reaches of the Mijares River. These vegetation changes have accompanied a decrease in the magnitude and variability of river flows over the last six decades, with higher severity since dam closure. This study illustrates the effectiveness of combining disparate historical data sources and the effectiveness of processing these sources to extract informative metrics that can improve the understanding and management of riparian systems. Copyright © 2012 John Wiley & Sons, Ltd.