bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can breastfeeding promote child health equity? A comprehensive analysis of breastfeeding patterns across the developing world and what we can learn from them
Authors: Roberts Thomas J , Carnahan Emily , Gakidou Emmanuela 
Published: December 2013

Abstract

Background
In 2010 more than 7.7 million children died before their fifth birthday. Over 98% of these deaths occurred in developing countries, and recent estimates have attributed hundreds of thousands of these deaths to suboptimal breastfeeding.

Methods
This study estimated prevalence of suboptimal breastfeeding for 137 developing countries from 1990 to 2010. These estimates were compared against WHO infant feeding recommendations and combined with effect sizes from existing literature to estimate associated disease burden using a standard comparative risk assessment approach. These prevalence estimates were disaggregated by wealth quintile and linked with child mortality rates to assess how improved rates of breastfeeding may affect child health inequalities.

Results
In 2010, the prevalence of exclusive breastfeeding ranged from 3.5% in Djibouti to 77.3% in Rwanda. The proportion of child Disability Adjusted Life Years (DALYs) attributable to suboptimal breastfeeding is 7.6% at the global level and as high as 20.2% in Swaziland. Suboptimal breastfeeding is a leading childhood risk factor in all developing countries and consistently ranks higher than water and sanitation. Within most countries, breastfeeding prevalence rates do not vary considerably across wealth quintiles.

Conclusions
Breastfeeding is an effective child health intervention that does not require extensive health system infrastructure. Improvements in rates of exclusive and continued breastfeeding can contribute to the reduction of child mortality inequalities in developing countries.
On the application of multi-class classification in physical therapy recommendation
Authors: Zhang Jing , Cao Peng , Gross Douglas P , Zaiane Osmar R 
Published: December 2013

AbstractRecommending optimal rehabilitation intervention for injured workers that would lead to successful return-to-work (RTW) is a challenge for clinicians. Currently, the clinicians are unable to identify with complete confidence which intervention is best for a patient and the referral is often made in trial and error fashion. Only 58% recommendations are successful in our dataset. We aim to develop an interpretable decision support system using machine learning to assist the clinicians. We proposed an alternate ripper (ARIPPER) combined with a hybrid re-sampling technique, and a balanced weighted random forests (BWRF) ensemble method respectively, in order to tackle the multi-class imbalance, class overlap and noise problem in real world application data. The final models have shown promising potential in classification compared to human baseline and has been integrated into a web-based decision-support tool that requires additional validation in a clinical sample.
PDL241, a novel humanized monoclonal antibody, reveals CD319 as a therapeutic target for rheumatoid arthritis
Authors: Woo Jacky , Vierboom Michel PM , Kwon Hakju , Chao Debra , Ye Shiming , Li Jianmin , Lin Karen , Tang Irene , Belmar Nicole A , Hartman Taymar , Breedveld Elia , Vexler Vladimir , ‘t Hart Bert A , Law Debbie A , Starling Gary C 
Published: December 2013

Abstract
Introduction
Targeting the CD20 antigen has been a successful therapeutic intervention in the treatment of rheumatoid arthritis (RA). However, in some patients with an inadequate response to anti-CD20 therapy, a persistence of CD20- plasmablasts is noted. The strong expression of CD319 on CD20- plasmablast and plasma cell populations in RA synovium led to the investigation of the potential of CD319 as a therapeutic target.

Methods
PDL241, a novel humanized IgG1 monoclonal antibody (mAb) to CD319, was generated and examined for its ability to inhibit immunoglobulin production from plasmablasts and plasma cells generated from peripheral blood mononuclear cells (PBMC) in the presence and absence of RA synovial fibroblasts (RA-SF). The in vivo activity of PDL241 was determined in a human PBMC transfer into NOD scid IL-2 gamma chain knockout (NSG) mouse model. Finally, the ability of PDL241 to ameliorate experimental arthritis was evaluated in a collagen-induced arthritis (CIA) model in rhesus monkeys.

Results
PDL241 bound to plasmablasts and plasma cells but not naïve B cells. Consistent with the binding profile, PDL241 inhibited the production of IgM from in vitro PBMC cultures by the depletion of CD319+ plasmablasts and plasma cells but not B cells. The activity of PDL241 was dependent on an intact Fc portion of the IgG1 and mediated predominantly by natural killer cells. Inhibition of IgM production was also observed in the human PBMC transfer to NSG mouse model. Treatment of rhesus monkeys in a CIA model with PDL241 led to a significant inhibition of anti-collagen IgG and IgM antibodies. A beneficial effect on joint related parameters, including bone remodeling, histopathology, and joint swelling was also observed.

Conclusions
The activity of PDL241 in both in vitro and in vivo models highlights the potential of CD319 as a therapeutic target in RA.
System and Individual Outcomes and Their Predictors in Services and Support for People with IDD
Authors: Tichá Renáta , Hewitt Amy , Nord Derek , Larson Sherri 
Published: December 2013

Abstract
The growth and advancement of community-based services for people with intellectual and developmental disabilities (IDD) have resulted in vast changes in the long-term services and support landscape as well as in expected outcomes of service systems for service recipients. Investments in IDD research have been made to provide a deeper understanding of these outcomes and to explain them. This article summarizes outcomes and their predictors through systems and individual lenses by examining the research and findings of the Administration on Intellectual and Developmental Disabilities' Data Projects of National Significance that address residential services, employment services, costs of services, and individual outcomes. The article also discusses challenges and debates associated with outcome-related research and poses future research questions.
The State of the Science of Health and Wellness for Adults With Intellectual and Developmental Disabilities
Authors: Anderson Lynda Lahti , Humphries Kathy , McDermott Suzanne , Marks Beth , Sisirak Jasmina , Larson Sheryl 
Published: December 2013

AbstractHistorically, people with intellectual and developmental disabilities (IDD) have experienced health disparities related to several factors including: a lack of access to high quality medical care, inadequate preparation of health care providers to meet their needs, the social determinants of health (e.g., poverty, race and gender), and the failure to include people with IDD in public health efforts and other prevention activities. Over the past decade, a greater effort has been made to both identify and begin to address myriad health disparities experienced by people with IDD through a variety of activities including programs that address health lifestyles and greater attention to the training of health care providers. Gaps in the literature include the lack of intervention trials, replications of successful approaches, and data that allow for better comparisons between people with IDD and without IDD living in the same communities. Implications for future research needed to reduce health disparities for people with IDD include: better monitoring and treatment for chronic conditions common in the general population that are also experienced by people with IDD, an enhanced understanding of how to promote health among those in the IDD population who are aging, addressing the health needs of people with IDD who are not part of the disability service system, developing a better understanding of how to include people with IDD in health and wellness programs, and improving methods for addressing the health care needs of members of this group in an efficient and cost-effective manner, either through better access to general medical care or specialized programs.
Using Research Evidence to Inform Public Policy Decisions
Authors: Moseley Charles , Kleinert Harold , Sheppard-Jones Kathleen , Hall Stephen 
Published: December 2013

Abstract
The application of scientific data in the development and implementation of sound public policy is a well-established practice, but there appears to be less consensus on the nature of the strategies that can and should be used to incorporate research data into policy decisions. This paper describes the promise and the challenges of using research evidence to inform public policy. Most specifically, we demonstrate how the application of a large-scale data set, the National Core Indicators (NCI), can be systematically used to drive state-level policy decisions, and we describe a case example of one state's application of NCI data to make significant changes to its Intellectual and Developmental Disabilities waiver. The need for continued research in this area is highlighted.
Unfertige Dialoge – Das Berliner Förderprogramm Digitalisierung
Authors: Müller Anja , Rusch Beate , Amrhein Kilian , Klindt Marco 
Published: December 2013

Zusammenfassung:
Das Förderprogramm Digitalisierung des Landes Berlin fördert Digitalisierungsprojekte in Berliner Kulturerbeeinrichtungen und hat parallel dazu die Servicestelle Digitalisierung (digiS) als zentrale Beratungs- und Koordinierungsstelle eingerichtet. Ziel ist dabei, eine technische und organisatorische Infrastruktur für die Projekte sowie zur Sicherung der Langzeitverfügbarkeit digitalen Kulturguts vorzuhalten. Der Artikel beschreibt das Förderprogramm, das Aufgabenspektrum von digiS und die Herausforderungen, die sich für Kulturerbeinstitutionen ergeben, wenn sie sich auf den offenen Dialog mit ihren Nutzern einlassen und ihre Objekte digital langzeitverfügbar halten wollen.
Koordinierungsstelle Brandenburg-digital
Authors: Preuß Ulf 
Published: December 2013

Zusammenfassung:
Ende 2012 wurde an der Fachhochschule Potsdam die Koordinierungsstelle Brandenburg-digital eingerichtet. Sie wird durch das Ministerium für Wissenschaft, Forschung und Kultur des Landes Brandenburg gefördert. Ihre Hauptaufgabe besteht darin, brandenburgische Digitalisierungsprojekte beratend zu unterstützen. Ein Arbeitskreis Brandenburg.digital, mit Vertretern aller Kultursparten, bildet die Basis eines Kooperations- und Kompetenznetzwerks für die Vermittlung von Kultureinrichtungen an regionale Kooperationspartner. Neben der regionalen Verankerung bestehen kooperative Verbindungen zu Einrichtungen in anderen Bundesländern und zum Netzwerk der Deutschen Digitalen Bibliothek.
Das Projekt Blended Library an der Universitätsbibliothek Tübingen – ein Statusbericht
Authors: Bogorin Alexandru , Parditka Gabriella , Rempis Peter 
Published: December 2013

Zusammenfassung:
Der Beitrag berichtet vom aktuellen Stand des Projektes „Blended Library“ an der Universitätsbibliothek Tübingen. Im Zentrum des Projektes steht die Untersuchung der Eignung interaktiver Multitouch-Tische zur Gestaltung des Lern-, Arbeits- und Kommunikationsortes Bibliothek. Erfahrungen aus der Unterstützung der Lehre stehen im Bericht im Vordergrund. Vor- und Nachteile der interaktiven Tische werden auf der Grundlage einiger Beispiele angesprochen.
Opposing Activities of DRM and MES-4 Tune Gene Expression and X-Chromosome Repression inCaenorhabditis elegansGerm Cells
Authors: Tabuchi Tomoko M , Rechtsteiner Andreas , Strome Susan , Hagstrom Kirsten A 
Published: December 2013

AbstractDuring animal development, gene transcription is tuned to tissue-appropriate levels. Here we uncover antagonistic regulation of transcript levels in the germline of Caenorhabditis elegans hermaphrodites. The histone methyltransferase MES-4 (Maternal Effect Sterile-4) marks genes expressed in the germline with methylated lysine on histone H3 (H3K36me) and promotes their transcription; MES-4 also represses genes normally expressed in somatic cells and genes on the X chromosome. The DRM transcription factor complex, named for its Dp/E2F, Retinoblastoma-like, and MuvB subunits, affects germline gene expression and prevents excessive repression of X-chromosome genes. Using genome-scale analyses of germline tissue, we show that common germline-expressed genes are activated by MES-4 and repressed by DRM, and that MES-4 and DRM co-bind many germline-expressed genes. Reciprocally, MES-4 represses and DRM activates a set of autosomal soma-expressed genes and overall X-chromosome gene expression. Mutations in mes-4 and the DRM subunit lin-54 oppositely skew the transcript levels of their common targets and cause sterility. A double mutant restores target gene transcript levels closer to wild type, and the concomitant loss of lin-54 suppresses the severe germline proliferation defect observed in mes-4 single mutants. Together, “yin-yang” regulation by MES-4 and DRM ensures transcript levels appropriate for germ-cell function, elicits robust but not excessive dampening of X-chromosome-wide transcription, and may poise genes for future expression changes. Our study reveals that conserved transcriptional regulators implicated in development and cancer counteract each other to fine-tune transcript dosage.
Estimating Scale Deposition Through Reservoir History Matching in the Janice Field
Authors: Vazquez Oscar , Young Callum , Demyanov Vasily , Arnold Dan , Fisher Andrew , MacMillan Alasdair , Christie Mike 
Published: December 2013

Summary
Inorganic-scale precipitation and deposition in production wells can be a significant impediment to effective reservoir management. In extreme cases, scale can cause the well to be abandoned as a result of reservoir-formation damage in the near-wellbore region and the narrowing of the production-tubing annulus, thus preventing fluid flow. The prediction of the time and location of scale formation is therefore essential for scale management. This study is focused on sulfate scales, which form when sulfate-rich seawater mixes with formation brines that are rich in barium, calcium, and strontium, and which are among the most difficult types of scale to prevent and remove.
Formation brines in reservoirs with a tendency for sulfate-scale deposition can have a very different makeup when compared with seawater, which may be injected for pressure support. Having such different chemistries allows seawater and formation brine to be tracked. In this study, two different types of water are considered: formation brine and injected seawater.
The objective of this work is to predict uncertainty in sulfate-scale deposition from multiple history-matched reservoir models by tracking injected seawater in the Janice field. There are many examples in the literature in which conventional reservoir history matching (namely, gas rate, oil rate, and bottomhole pressure) are used to generate an ensemble of good history-matched models that will estimate uncertainty of a hydrocarbon-reservoir production. In this study, the same approach will be adopted, but including produced-water chemistry—in particular, seawater breakthrough. This approach provides a methodology to predict the uncertainty of the formation-brine/injected-seawater mixing zone within the reservoir formation. The methodology provides a Bayesian confidence interval (P10/P50/P90) in time and space for the injected seawater, identifying which wells will be at risk on the basis of seawater breakthrough and in which zones of the reservoir mixing is more likely to occur.
Effect of Toothbrushing-mouthrinse-cycling on Surface Roughness and Topography of Nanofilled, Microfilled, and Microhybrid Resin Composites
Authors: da Silva EM , de Sá Rodrigues CUF , Dias DA , da Silva S , Amaral CM , Guimarães JGA 
Published: December 2013

SUMMARY
The purpose of this study was to evaluate the influence of toothbrushing-mouthrinse-cycling (TMC) on the surface roughness and topography of three resin composites with different filler particle systems (Z350, nanofilled [Nf]; Durafill, microfilled [Mf], and Empress Direct, microhybrid [Mh]). Twenty specimens of each resin composite (8.0 mm diameter and 2 mm height) were randomly divided into four groups (n=5) according to the mouthrinses: alcohol-free (Plax – P) and alcohol-containing (Listerine – L and Plax Fresh Mint – PM) and artificial saliva (control – AS). The specimens were submitted to TMC for nine weeks. A surface roughness tester and a three-dimensional profilometer were used to measure the roughness (Ra) and the topography (Sa) before and after TMC. The data were analyzed by multifactor analysis of variance and Tukey post hoc test (α=0.05). In all media, Mh presented greater roughness than Mf (p&lt;0.05). The highest value of roughness was presented by Mh immersed in L (p&lt;0.05). The lowest values of roughness were presented by Mf (p&lt;0.05). The three resin composites presented the highest roughness after immersion in mouthrinses containing alcohol (PM and L) (p&lt;0.05). For the three resin composites, the increase in roughness was noticeable after the fifth week. Topographic analysis showed that the smoothest surfaces were present after immersion in AS.
Value of Non-Invasive Fetal Monitoring Techniques in Detection of Fetal Metabolic Acidemia at Birth
Authors: Dokus K , Matasova K , Visnovsky J , Dokusova S , Danko J. 
Published: December 2013

Abstract
Objective. Purpose of the study was to evaluate the diagnostic accuracy of fetal pulse oximetry (FPO) and STanalysis of the fetal ECG (STAN) in prediction of fetal acidemia at birth. Methods. A prospective clinical study was conducted at the Department of Obstetrics and Gynaecology, Jessenius Faculty of Medicine, Martin, Slovakia. In total, 63 out of 70 women with non-reassuring CTG patterns in labour were enrolled. Fetal surveillance during the labour continued with simultaneous CTG plus FPO and STAN monitoring. A receiver operating curve (ROC) analysis was performed to ascertain diagnostic accuracy of individual methods. Results. The study confirmed FPO has a significant ability to detect fetal acidemia at birth (UA-pH ≤ 7.2). The optimum diagnostic cut-off value of SpO2 was 33%, with FPO’s diagnostic sensitivity 60%, and specificity 85.2%. The diagnostic accuracies of STAN + CTG and CTG alone were inferior to that of FPO. Conclusions. FPO has an ability to predict fetal birth acidemia (UA-pH ≤ 7.2), and its diagnostic accuracy is superior to STAN + CTG, or CTG alone monitoring. Condensation.FPO has ability to predict fetal birth acidemia (UA - pH≤7.2), and its diagnostic accuracy is superior to STAN + CTG, or CTG alone monitoring.
Point Prevalence Survey of Nosocomial Infections in University Hospital in Martin
Authors: Malobicka E , Roskova D , Svihrova V , Hudeckova H. 
Published: December 2013

Abstract
Nosocomial infections are a serious problem not only in Slovakia but in all countries. The European Commission decided on their standardized surveillance in the whole European Union. According methodology elaborated by experts from the European Centre for Disease Control and Prevention in Stockholm we performed a point prevalence survey in the University Hospital Martin.
Our observed prevalence of nosocomial infections in University Hospital Martin within the point prevalence study was 5.2%.
The highest point prevalence of nosocomial infections was found at the Surgical Department (9.3%).
The most common type of nosocomial infections was urological infections (27.3%), sepsis (22.7%) and surgical site infection (22.7%). The most common microorganisms isolated from the biological material were Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis. Appropriate method of nosocomial infections surveillance is monitoring their prevalence in the point prevalence studies. International projects of nosocomial infections in the EU allow to compare the obtained results with other hospitals in the Member States.
Cryopreservation of in vitro-grown shoot tips of chrysanthemum by encapsulation-dehydration
Authors: Zalewska Małgorzata , Kulus Dariusz 
Published: December 2013

ABSTRACT
Chrysanthemums are amongst the most economically important flowers in the world. The protection and storage of these valuable genetic resources is of great importance. Today, cryopreservation, or the storage of biological material at the temperature of liquid nitrogen (-196°C), is believed to be the most promising long-term storage method. To optimise the cryopreservation protocol, the shoot tips of Chrysanthemum × grandiflorum /Ramat./ Kitam. ‘Lady Orange’ and ‘Lady Salmon’ mutants were cryopreserved using the encapsulation-dehydration technique. During the experiment, the influence of sucrose concentration (2, 3 and 6%) during preculture and the concentration of kinetin (0.25, 0.5, 0.75 and 1.0 mg dm-3) in the regrowth medium were tested. A higher survival rate was observed for ‘Lady Salmon’. In general, the media with higher sucrose levels provided the best survival and recovery rates (35-40%). Kinetin had no influence on the survival rate; however, it influenced the morphogenesis of the plants. The lowest number of explants forming multiple shoots was observed on the medium with the lowest sucrose (during preculture) and kinetin (in the recovery medium) concentration. On the other hand, the best rhizogenesis efficiency was observed when 0.25 mg dm-3 kinetin was added. In conclusion, the composition of both preculture and recovery media need to be adjusted to single cultivars. The use of 3% sucrose (preculture) and 0.25 mg dm-3 kinetin (recovery) seems reasonable, since it guarantees a satisfying recovery rate of the explants and at the same time prevents the formation of callus and multiple shoots, stimulating the rooting instead.
Le rapport à l’emploi des femmes en congé parental [Un repositionnement vis-à-vis des normes sociales]
Authors: Kertudo Pauline 
Published: December 2013

This paper analyzes the manner in which the experience of parental leave influences the beneficiaries’ (almost exclusively women) prospects of regaining employment. It aims to show that the period spent at home encourages women to reposition themselves in relation to the prevailing normative models (concerning self-fulfilment, parental responsibilities, professional commitment..), which often causes stress. It specifically identifies four means of managing this experience, each corresponding to
separate pathways within the parental leave, which are reflected in different positionings with regard to returning to work at the end of the parental leave. Finally, it focuses on the temporality of parental leave and shows how the positioning of women with regard to norms evolves over the three years, without there being a real possibility to identify the key moments that determine the choice to return to work or to stay at home after the parental leave.