bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physician Posttraumatic Stress Disorder During COVID-19
Authors: Kamra Mihir , Dhaliwal Shan , Li Wenshan , Acharya Shrey , Wong Adrian , Zhu Andy , Vemulakonda Jaydev , Wilson Janet , Gibb Maya , Maskerine Courtney , Spilg Edward , Tanuseputro Peter , Myran Daniel T. , Solmi Marco , Sood Manish M. 
Published: July 2024

ImportanceThe COVID-19 pandemic placed many physicians in situations of increased stress and challenging resource allocation decisions. Insight into the prevalence of posttraumatic stress disorder in physicians and its risk factors during the COVID-19 pandemic will guide interventions to prevent its development.ObjectiveTo determine the prevalence of posttraumatic stress disorder (PTSD) among physicians during the COVID-19 pandemic and examine variations based on factors, such as sex, age, medical specialty, and career stage.Data SourcesA Preferred Reporting Items for Systematic Reviews and Meta-analyses–compliant systematic review was conducted, searching MEDLINE, Embase, and PsychInfo, from December 2019 to November 2022. Search terms included MeSH (medical subject heading) terms and keywords associated with physicians as the population and PTSD.Study SelectionPeer-reviewed published studies reporting on PTSD as a probable diagnosis via validated questionnaires or clinician diagnosis were included. The studies were reviewed by 6 reviewers.Data Extraction and SynthesisA random-effects meta-analysis was used to pool estimates of PTSD prevalence and calculate odds ratios (ORs) for relevant physician characteristics.Main Outcomes and MeasuresThe primary outcome of interest was the prevalence of PTSD in physicians, identified by standardized questionnaires.ResultsFifty-seven studies with a total of 28 965 participants and 25 countries were included (of those that reported sex: 5917 of 11 239 [52.6%] were male and 5322 of 11 239 [47.4%] were female; of those that reported career stage: 4148 of 11 186 [37.1%] were medical trainees and 7038 of 11 186 [62.9%] were attending physicians). The estimated pooled prevalence of PTSD was 18.3% (95% CI, 15.2%-22.8%; I2 = 97%). Fourteen studies (22.8%) reported sex, and it was found that female physicians were more likely to develop PTSD (OR, 1.93; 95% CI, 1.56-2.39). Of the 10 studies (17.5%) reporting age, younger physicians reported less PTSD. Among the 13 studies (22.8%) reporting specialty, PTSD was most common among emergency department doctors. Among the 16 studies (28.1%) reporting career stage, trainees were more prone to developing PTSD than attendings (OR, 1.33; 95% CI, 1.12-1.57).Conclusions and RelevanceIn this meta-analysis examining PTSD during COVID-19, 18.3% of physicians reported symptoms consistent with PTSD, with a higher risk in female physicians, older physiciansy, and trainees, and with variation by specialty. Targeted interventions to support physician well-being during traumatic events like pandemics are required.
Piezoelectric Analgesia Blocks Cancer‐Induced Bone Pain
Authors: Yin Yifei , Zhao Peiran , Xu Xianyun , Zhou Bangguo , Chen Jian , Jiang Xingwu , Liu Yanyan , Wu Yelin , Yue Wenwen , Xu Huixiong , Bu Wenbo 
Published: July 2024

AbstractThe manipulation of cell surface receptors’ activity will open a new frontier for drug development and disease treatment. However, limited by the desensitization of drugs, effective physical intervention strategy remains challenging. Here, the controllable internalization of transient receptor potential vanilloid 1 (TRPV1) on neural cells by local piezoelectric field is reported. Single‐cell‐level local electric field is construct by synthesizing piezoelectric BiOIO3 nanosheets (BIONSs). Upon a mild ultrasound of 0.08 W cm−2, an electric field of 15.29 µV is generated on the surface of BIONSs, further inducing TRPV1 internalization in 5 min. The as‐downregulated TRPV1 expression results in the reduction of Ca2+ signal in a spinal neuron and the inhibition of the activity of wide range dynamic neurons, therefore effectively preventing the transmission of cancer‐induced bone pain (CIBP). This strategy not only charts a new course for CIBP alleviation, but also introduces a promising nanotechnology for regulating cell surface receptors, showing significant potential in neuropathological and receptor‐related diseases.
Charge‐Transfer Complexes: Fundamentals and Advances in Catalysis, Sensing, and Optoelectronic Applications
Authors: Baharfar Mahroo , Hillier Andrew C. , Mao Guangzhao 
Published: July 2024

AbstractSupramolecular assemblies, formed through electronic charge transfer between two or more entities, represent a rich class of compounds dubbed as charge‐transfer complexes (CTCs). Their distinctive formation pathway, rooted in charge‐transfer processes at the interface of CTC‐forming components, results in the delocalization of electronic charge along molecular stacks, rendering CTCs intrinsic molecular conductors. Since the discovery of CTCs, intensive research has explored their unique properties including magnetism, conductivity, and superconductivity. Their more recently recognized semiconducting functionality has inspired recent developments in applications requiring organic semiconductors. In this context, CTCs offer a tuneable energy gap, unique charge‐transport properties, tailorable physicochemical interactions, photoresponsiveness, and the potential for scalable manufacturing. Here, an updated viewpoint on CTCs is provided, presenting them as emerging organic semiconductors. To this end, their electronic and chemical properties alongside their synthesis methods are reviewed. The unique properties of CTCs that benefit various related applications in the realms of organic optoelectronics, catalysts, and gas sensors are discussed. Insights for future developments and existing limitations are described.
Dual‐Intermetallic Heterostructure on Hierarchical Nanoporous Metal for Highly Efficient Alkaline Hydrogen Electrocatalysis
Authors: Shi Hang , Dai Tian‐Yi , Sun Xin‐Ying , Zhou Zhi‐Lan , Zeng Shu‐Pei , Wang Tong‐Hui , Han Gao‐Feng , Wen Zi , Fang Qian‐Rong , Lang Xing‐You , Jiang Qing 
Published: July 2024

AbstractConstructing well‐defined active multisites is an effective strategy to break linear scaling relationships to develop high‐efficiency catalysts toward multiple‐intermediate reactions. Here, dual‐intermetallic heterostructure composed of tungsten‐bridged Co3W and WNi4 intermetallic compounds seamlessly integrated on hierarchical nanoporous nickel skeleton is reported as a high‐performance nonprecious electrocatalyst for alkaline hydrogen evolution and oxidation reactions. By virtue of interfacial tungsten atoms configuring contiguous multisites with proper adsorptions of hydrogen and hydroxyl intermediates to accelerate water dissociation/combination and column‐nanostructured nickel skeleton facilitating electron and ion/molecule transportations, nanoporous nickel‐supported Co3W–WNi4 heterostructure exhibits exceptional hydrogen electrocatalysis in alkaline media, with outstanding durability and impressive catalytic activities for hydrogen oxidation reaction (geometric exchange current density of ≈6.62 mA cm−2) and hydrogen evolution reaction (current density of ≈1.45 A cm−2 at overpotential of 200 mV). Such atom‐ordered intermetallic heterostructure alternative to platinum group metals shows genuine potential for hydrogen production and utilization in hydroxide‐exchange‐membrane water electrolyzers and fuel cells.
Mitochondrial N‐Terminal Signal Sequences as Novel Antimicrobial and Annticancer Peptides
Authors: Jo Sang‐Heon , Lee Kyu‐Shik , Lee Min‐Gu , Yun Eun‐Young , Jeong Kyuho , Goo Tae Won 
Published: July 2024

AbstractN‐terminal mitochondrial targeting sequences (MTS) are signal peptides to drive the localization and import of mitochondrial protein and exhibit an amphipathic α‐helix structure similar to that of almost all antimicrobial peptides (AMPs). Here, 2,939 mitochondrial proteins are excavated from various organisms, and 574 MTS are selected with an MTS possibility score exceeding 0.5, as determined via MitoFates (http://mitf.cbrc.jp/MitoFates/cgi‐bin/top.cgi). 26 MTS composed of less than 20 amino acids is synthesized and analyzed their antimicrobial activities. The results showed that approximately 50% of MTS exhibited antimicrobial activity. Among them, human mitochondrial transcription termination factor 2 (hMTERF2‐ts) is identified as an AMP candidate with strong antimicrobial activity against gram‐positive and gram‐negative bacteria, antibiotics‐resistant (AR) bacteria, and fungi. Furthermore, it shows anticancer activities against various cancer cells, such as MDA‐MB‐231, HT‐29, HepG2, and Panc‐1 cells, with high stability against proteases, heat, pH, and salt, and low cytotoxicity toward normal cells, HaCaT and RAW 264.7. In addition, hMTERF2‐ts effectively prevented the growth of Panc‐1‐implanted tumors without weight loss in BALB/c nude mice. In conclusion, this study suggests that MTSs of protozoa are powerful and novel AMP candidates with low cytotoxicity against normal cells.
Nano‐Photonic Crystal D‐Shaped Fiber Devices for Label‐Free Biosensing at the Attomolar Limit of Detection
Authors: Del Villar Ignacio , Gonzalez‐Valencia Esteban , Kwietniewski Norbert , Burnat Dariusz , Armas Dayron , Pituła Emil , Janik Monika , Matías Ignacio R. , Giannetti Ambra , Torres Pedro , Chiavaioli Francesco , Śmietana Mateusz 
Published: July 2024

AbstractMaintaining both high sensitivity and large figure of merit (FoM) is crucial in regard to the performance of optical devices, particularly when they are intended for use as biosensors with extremely low limit of detection (LoD). Here, a stack of nano‐assembled layers in the form of 1D photonic crystal, deposited on D‐shaped single‐mode fibers, is created to meet these criteria, resulting in the generation of Bloch surface wave resonances. The increase in the contrast between high and low refractive index (RI) nano‐layers, along with the reduction of losses, enables not only to achieve high sensitivity, but also a narrowed resonance bandwidth, leading to a significant enhancement in the FoM. Preliminary testing for bulk RI sensitivity is carried out, and the effect of an additional nano‐layer that mimics a biological layer where binding interactions occur is also considered. Finally, the biosensing capability is assessed by detecting immunoglobulin G in serum at very low concentrations, and a record LoD of 70 aM is achieved. An optical fiber biosensor that is capable of attaining extraordinarily low LoD in the attomolar range is not only a remarkable technical outcome, but can also be envisaged as a powerful tool for early diagnosis of diseases.
Fluorinated Naphthalene Diimides as Buried Electron Transport Materials Achieve Over 23% Efficient Perovskite Solar Cells
Authors: Li Xiaofeng , Wang Wanhai , Huang Pengyu , Yang Li , Hu Jianfei , Wei Kun , Gao Liang , Jiang Yonghe , Sun Kexuan , Du Guozheng , Cai Xuanyi , Liu Chang , Tang Weihua , Zhang Jinbao 
Published: July 2024

AbstractNaphthalene diimides (NDI) are widely serving as the skeleton to construct electron transport materials (ETMs) for optoelectronic devices. However, most of the reported NDI‐based ETMs suffer from poor interfaces with the perovskite which deteriorates the carrier extraction and device stability. Here, a representative design concept for editing the peripheral groups of NDI molecules to achieve multifunctional properties is introduced. The resulting molecule 2,7‐bis(2,2,3,3,4,4,4‐heptafluorobutyl)benzo[lmn][3,8]phenanthroline‐1,3,6,8(2H,7H)‐tetraone (NDI‐C4F) incorporated with hydrophobic fluorine units contributes to the prevention of excessive molecular aggregation, the improvement of surface wettability and the formation of strong chemical coordination with perovskite precursors. All these features favor retarding the perovskite crystallization and achieving superior buried interfaces, which subsequently promote charge collection and improve the structural compatibility between perovskite and ETMs. The corresponding PSCs based on low‐temperature processed NDI‐C4F yield a record efficiency of 23.21%, which is the highest reported value for organic ETMs in n‐i‐p PSCs. More encouragingly, the unencapsulated devices with NDI‐C4F demonstrate extraordinary stability by retaining over 90% of their initial PCEs after 2600 h in air. This work provides an alternative molecular strategy to engineer the buried interfaces and can trigger further development of organic ETMs toward reliable PSCs.
Pyro‐Phototronic Effect Induced Circularly Polarized Light Detection with a Broadband Response
Authors: Guan Qianwen , Zhu Zeng‐Kui , Ye Huang , Zhang Chengshu , Li Hang , Ji Chengmin , Liu Xitao , Luo Junhua 
Published: July 2024

AbstractPhotopyroelectric‐based circularly polarized light (CPL) detection, coupling the pyro‐phototronic effect and chiroptical phenomena, has provided a promising platform for high‐performance CPL detectors. However, as a novel detection strategy, photopyroelectric‐based CPL detection is currently restricted by the short‐wave optical response, underscoring the urgent need to extend its response range. Herein, visible‐to‐near‐infrared CPL detection induced by the pyro‐phototronic effect is first realized in chiral‐polar perovskites. Specifically, chiral‐polar multilayered perovskites (S‐BPEA)2FAPb2I7 (1‐S, S‐BPEA = (S)‐1‐4‐Bromophenylethylammonium, FA = formamidinium) with spontaneous polarization shows intrinsic pyroelectric and photopyroelectric performance. Strikingly, combining its merits of the pyro‐phototronic effect and intrinsic wide‐spectrum spin‐selective effect, chiral multilayered 1‐S presents efficient photopyroelectric‐based broadband CPL detection performance spanning 405–785 nm. This research first realizes photopyroelectric‐based infrared CPL detection and also sheds light on developing high‐performance broadband CPL detectors based on the pyro‐phototronic effect in the fields of optics, optoelectronics, and spintronics.
Cover crop and wheel‐track effects on soil properties under cotton production in eastern Arkansas
Authors: Lebeau Shelby G. , Brye Kristofor R. , Daniels Michael , Wood Lisa S. 
Published: July 2024

AbstractRepetitive use of heavy farm machinery in cultivated agriculture may cause soil compaction that can adversely affect soil‐health‐related properties. Cover crops (CC) are well‐documented to alleviate problems associated with compaction and improve overall soil health in time. The objective of this field study was to evaluate the cumulative effects of CC treatment (i.e., with ≥ 6 years cereal rye [Secale cereale L.] CC and ≥ 4 years with no cover crop [NCC]) and sample/measurement placement (i.e., in the bed [B] and in the wheel‐track [WT] and no‐wheel‐track [NWT] furrow) on near‐surface soil physical‐, chemical‐, and infiltration‐related properties in an alluvial soil under cotton (Gossypium hirsutum L.) production in the Lower Mississippi River Valley. Samples were collected and in‐situ measurements were conducted in late May 2019 within a single field in eastern Arkansas. Overall‐infiltration rate was two times greater (p ≤ 0.01) in B compared to WT and NWT placement, which did not differ. Soil bulk density in WT was 1.1 times greater than the other two placements, while soil organic matter was greater in CC‐WT (30.7 Mg ha−1) than in all other treatment‐placement combinations, except for CC‐NWT, which did not differ. Similarly, water‐stable‐aggregate concentration was 2.3 and 1.6 times greater in the CC‐NWT and CC‐WT combinations, respectively, which did not differ, compared to under NCC. Results demonstrated that CC benefits extended beyond the bed to positively affect soil properties in adjacent WT and NWT furrows. Continued small‐scale, long‐term management studies using CC will extend insight into site‐specific, soil‐health improvements.
Effects of vermicompost and mineral fertilizers on soil properties, malt barley (Hordeum distichum L.) yield, and economic benefits
Authors: Terefe Zenebe , Feyisa Tesfaye , Molla Eyayu , Ejigu Workineh 
Published: July 2024

AbstractSoil fertility depletion has significantly reduced the yields of various crops in Ethiopia, mainly the yield of malt barley in the district. To address this issue, integrated applications of vermicompost and mineral nitrogen (N) fertilizers were tested. Therefore, this study aimed to evaluate the effects of vermicompost and mineral nitrogen fertilizers application on malt barley yield (Hordeum distichum L.), soil properties, and economic benefits. The experiment was arranged in a randomized complete block design with three replications. The treatments were nine in various combinations of vermicompost (VC) and N fertilizer (N): (69 kg N; 0.79 t VC + 58.65 kg N; 1.59 t VC + 48.30 kg N; 2.39 t VC + 37.95 kg N; 3.19 t VC + 27.60 kg N; 3.98 t VC + 17.25 kg N; 4.78 t VC + 6.90 kg N; 5.31 t VC ha−1 and control). The highest soil pH was recorded by applying 5.31 t of vermicompost ha−1 alone. The highest total nitrogen (0.34%), available phosphorus (15.58 mg kg−1), grain yield (4950 kg ha−1), and net benefit (4255.74 USD) were recorded from the application of 2.39 t VC plus 37.95 kg N, while the highest soil organic carbon (3.38%) and cation exchange capacity (26.17 cmol (+) kg−1) were recorded from 3.19 t VC plus 27.60 kg N ha−1 compared to the control. This study concludes that applying 2.39 t VC and 37.95 kg N ha−1 in combination improves soil fertility, malt barley yield, and economic benefits for smallholder farmers in the study district and adopts this in similar soil types and agroecologies.
Polyvinylidene fluoride gel‐polyethylene composite separator optimizing the interface compatibility between the separator and the electrode
Authors: Chen Qian , Yang Ling , Gao Xingxu , Li Datuan , Sun Ao , Niu Jing , Bai Yaozong , Dong Haoyu , Liu Gaojun , Sheng Lei , Wang Tao , Huang Xianli , He Jianping 
Published: July 2024

AbstractThe interface issue concerning lithium dendrite formation between the separator and electrode remains a significant impediment to the further advancement of lithium‐ion batteries (LIB). Due to the inadequate interface compatibility between the conventional polyolefin separator and the electrode, there is a propensity for lithium dendrite growth. In this work, the surface of the polyethylene (PE) separator is coated with polyvinylidene fluoride (PVDF) gel using a simple phase transformation method, resulting in the preparation of a composite separator consisting of PE and PVDF. The results demonstrate an enhanced interface compatibility following the introduction of the gel layer, with a polarization voltage as low as 0.14 V observed after 250 h of cycling. Additionally, the ionic conductivity of the PE/PVDF composite separator (1.77 mS cm−1) is enhanced, attributed to the incorporation of F functional group in PVDF gel, which could facilitate the formation of a rapid ion transport pathway through the interaction between F functional group and Li+. After the introduction of the gel layer, the discharge capacity of the battery after 250 cycles measures ~1.28 mAh, with a mere 27% decay in capacity. This study presents a novel concept for the design of composite separator in LIB.
Paclitaxel‐coated versus sirolimus‐coated balloon angioplasty for coronary artery disease: A systematic review and meta‐analysis
Authors: Shin Doosup , Singh Mandeep , Shlofmitz Evan , Scheller Bruno , Latib Azeem , Kandzari David E. , Zaman Azfar , Mylotte Darren , Dakroub Ali , Malik Sarah , Sakai Koshiro , Jeremias Allen , Moses Jeffrey W. , Shlofmitz Richard A. , Stone Gregg W. , Ali Ziad A. 
Published: July 2024

AbstractBackgroundAlthough use of sirolimus‐based analogs has shown superiority over paclitaxel in drug‐eluting stents, the relative efficacy of these two agents released from drug‐coated balloons (DCB) is unclear. The present meta‐analysis is aimed to compare outcomes after percutaneous coronary intervention (PCI) with paclitaxel‐coated balloons (PCB) versus sirolimus‐coated balloons (SCB) for either in‐stent restenosis or native de novo lesions.MethodsThe study outcomes were 1) target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization, and 2) follow‐up angiographic parameters including late lumen loss (LLL), diameter stenosis, and minimal lumen diameter (MLD). Pooled odds ratios (OR) and weighted mean differences (WMD) with 95% confidence intervals (CI) were calculated by using random‐effects models.ResultsA search of PubMed, EMBASE, and Cochrane Library from their inception to January 2024 identified five randomized clinical trials and three observational studies with a total of 1861 patients (889 in PCB and 972 in SCB groups). During 9–12 months of follow‐up, there was no significant difference in TLF (OR 1.01, 95% CI 0.75–1.35) between the two groups. On follow‐up angiography at 6–9 months, MLD (WMD 0.10, 95% CI 0.02–0.17) was larger in PCB but there was no statistically significant difference in LLL (WMD −0.11, 95% CI −0.23–0.02) and diameter stenosis (WMD −3.33, 95% CI −8.11–1.45).ConclusionsAmong patients undergoing DCB‐only PCI, the risk of TLF was similar during 9–12 months of follow‐up after PCB and SCB treatment. However, the MLD was larger favoring PCB over SCB on follow‐up angiography.
Molecular Imprinting‐involving Highly Selective Tetracycline Detection Platform Based on Mn2V2O7 with Excellent Oxidase‐mimicking Activity
Authors: Zhao Huanjun , Xu Xinxin , Chen Jin 
Published: July 2024

AbstractNanozymes‐involving colorimetry may represent an effective solution to tetracycline detection due to its affordability and simplicity. To improve the performance in selectivity, molecular imprinting technology has emerged as a promising approach to simulating the interaction between antibodies and receptors. Herein, Mn2V2O7, a form of nanozyme with oxidase‐mimicking activity, was synthesized. With tetracycline as the template, the cavities with unique dimensions were constructed through the self‐polymerization of dopamine (DA) on Mn2V2O7. In Mn2V2O7@MIP, polydopamine (PDA) acts as molecularly imprinted polymer (MIP) and its cavities are compatible with tetracycline in dimension. It also exhibits oxidase‐mimicking activity. With the introduction of tetracycline, the cavity of PDA is blocked, which leads to obvious color fading, which enables precise tetracycline detection with colorimetry. The range of linear detection is from 10 to 100 μM, and the lower limit of detection is 0.82 μM. It is anticipated that the combination between nanozymes‐involving colorimetry and molecular imprinting technology would contribute to the accurate detection of organic pollutants in the aquatic environment.
Surface Engineering of N‐Doped Carbon Derived from Polyaniline for Primary Zinc‐Air Batteries
Authors: Chávez‐Hernández Ángel , Ramos‐Castillo Carlos M. , Olivas Amelia , Delgado Anabel D. , Guerra‐Balcázar Minerva , Álvarez‐Contreras Lorena , Arjona Noé 
Published: July 2024

AbstractZinc‐air batteries (ZABs) with metal‐free cathodes are considered environmentally friendly and cost‐effective. However, more active and durable catalysts are required for this purpose. Herein, polyaniline (PANI)‐derived carbon materials were obtained to boost the oxygen reduction reaction (ORR) and, consequently, the performance of a primary ZAB. The developed porous N‐doped carbon (NDC) materials were engineered by varying the polymerization time and calcination temperature (500–900 °C). SEM micrographs and BET surface areas showed that the polymerization of aniline under cold conditions (5 °C) at 6, 8, or 24 h did not have a significant effect on the morphology or surface area. The fibrous structure of PANI was engineered by temperature, resulting in a progressive increase in the surface area until a three‐dimensional porous structure was achieved at 900 °C with the highest area of 601.9 m2 g−1. The surface doping of nitrogen species shifted from PANI‐rich N species to enriched graphitic N from 12.69 % (500 °C) to 24.26 % at 900 °C. The NDC 900 °C presented a voltage of 1.4 V and power density of 56 mW cm−2 (only 7 mW cm−2 lower than that of Pt/C). The results demonstrate that this material is an excellent candidate for high‐performance primary ZABs.