bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approaches to assessment of technological and economic efficiency of infill drilling in carbonate sediments - A case study of Berket-Klyuchevskoye oil field in the Republic of Tatarstan
Authors: Петров В.Н. , Кабирова А.Х. , Хуснутдинов Р.Н. , Сайфутдинов М.А. , Габдрахманов Н.Х. , Яртиев А.Ф. 
Published: July 2024

Традиционные подходы к разработке нефтяных месторождений на поздней стадии приводят к локализации значительного объема запасов нефти в межскважинном пространстве. В настоящий момент, существует целый ряд эффективных технологических решений, направленных на доизвлечение запасов нефти на действующих месторождениях. Одним из путей решения проблемы довыработки остаточных запасов нефти, сконцентрированных в слабодренируемых и застойных зонах, является уплотнение сетки скважин. В данной статье приведён пример технологических решений, направленных на уплотнение сетки скважин на карбонатных коллекторах Беркет-Ключевского нефтяного месторождения Республики Татарстан. Рассмотрены различные варианты по дальнейшей разработке залежи нефти с использованием геолого-гидродинамического моделирования. Показаны результаты прогнозных технико-экономических показателей разработки от предлагаемых технологических решений, направленных на увеличение степени выработки запасов в межскважинном пространстве и повышение конечного коэффициента извлечения нефти.
Traditional approaches to oil field development at late stages result in localization of a substantial portion of oil reserves in the inter-well space. Today, a number of effective technological solutions aimed at recovery of residual oil reserves in producing fields are available. One of the approaches to addressing the problem of recovery of residual oil reserves locked in poorly drained and stagnant zones provides for infill drilling. The paper presents an example of infill drilling operations conducted in carbonate reservoirs of Berket-Klyuchevskoye oil field in the Republic of Tatarstan. Various options for further development of the field using geological and reservoir simulation modeling are considered. Forecast production data due to application of proposed technological solutions aimed at enhancing oil recovery in the inter-well space and increasing the ultimate oil recovery factor are presented.
Methods of combating watering in gas condensate wells, possibilities of using surfactants and rationale for its selection
Authors: Гусейнов Э.Б.о. , Зарипов А.Т. , Султанбеков Р.Р. , Шайхутдинова А.Ф. 
Published: July 2024

В статье рассмотрены методы отечественных и зарубежных технологий эксплуатации газоконденсатных скважин. Приведенынаиболее вероятные причины обводнения газоконденсатных скважин, детально рассмотрены способы борьбы с обводнением, существующие типы и современные виды поверхностно-активных веществ, методы подбора поверхностно-активных веществ, оборудования для лабораторных исследований, а также способы доставки поверхностно-активных веществ на забой газоконденсатной скважины с горизонтальным окончанием с целью выноса жидкости с забоя.
The article discusses methods of domestic and foreign technologies for operating gas condensate wells. The most probable reasons for watering of gas condensate wells are given, methods of combating watering, existing types and modern types of surfactants, methods for selecting surfactants, equipment for laboratory research, as well as methods for delivering surfactants to the bottom of a gas condensate well with horizontal end for the purpose of removing fluid from the bottom.
The Impact of Social Media on Business Performance of Women Entrepreneurs and their Empowerment: A Mixed Methods Study in the Context of Sri Lanka
Authors: De Silva Thilini , Hansson Henrik 
Published: July 2024

The impact of social media on business performance of women entrepreneurs and their empowerment is examined in this research. Focusing on Sri Lanka, two research questions are addressed: (1) How are social media platforms empowering women entrepreneurs in Sri Lanka today, and (2) How can the use of social media be improved to support women entrepreneurs in Sri Lanka? A mixed-methods approach was used, with a survey (157 responses) and an online focus group (5 respondents) discussion. The statistical findings showed that business performance of women entrepreneurs mediates the relationship between use of social media and women’s empowerment. Qualitative analysis revealed that the use of social media transforms mindsets, facilitates knowledge sharing, provides motivation, supports business operations, promotes gender-neutral branding, and enables networking for women entrepreneurs in Sri Lanka to enhance the performance of their businesses, leading to empowerment. To enhance support, social media platforms should prioritize motivation, targeted networking, professional courses, and robust security measures.
Desajustados da Floresta
Authors: Brulon Bruno 
Published: July 2024

Adotando a indisciplina como ponto de vista para observar museus e exposições, este artigo analisa a exposição Queermuseu: cartografias da diferença na arte brasileira, cuja censura em 2017 levou a um movimento no Rio de Janeiro pela sua abertura na Escola de Artes Visuais do Parque Lage, entre agosto e setembro de 2018. Nossa análise se baseia no potencial de insubordinação de uma exposição que se tornou um devir do socio-ativismo museal no contexto político brasileiro nos anos que antecederam Ã eleição do presidente Jair Bolsonaro. Com base na análise etnográfica da exposição e do programa educativo da EAV, buscamos compreender as disputas de narrativa sobre o “queer” e o “normal” ou o “ajustado”, denunciando a violência museal sobre os corpos dissidentes e discutindo as apropriações contemporâneas dos museus em sua insubordinação ao poder disciplinar.
GAMBARAN KEBUTUHAN PENYULUHAN YANG DIPERLUKAN OLEH GURU DALAM PEMBELAJARAN DI SMK BINA BHAKTI CILACAP
Authors: Ani Lusi 
Published: July 2024

Guru mempunyai peran yang penting dalam tercapainya tujuan pembelajaran, dalam mendukung hal tersebut maka guru perlu memiliki kompetensi yang cukup baik kompetensi pedagogik maupun kompetensi professional. Peningkatan kompetensi yang harus dimiliki guru tersebut dapat didukung melalui kegiatan penyuluhan terkait pembelajaran, sehingga penulis tertarik memberikan gambaran kebutuhan penyuluhan yang diperlukan oleh Guru dalam pembelajaran di SMK Bina Bhakti Cilacap. Metode yang digunakan yakni metode penelitian kualitatif melalui pendekatan deskriptif serta kuantitatif. Lokasi kajian yakni di SMK Bina Bhakti Cilacap secara offline dengan subjek Guru pada sekolah tersebut. Disimpulkan yakni kebutuhan penyuluhan terkait pembelajaran yang diperlukan oleh Guru di SMK Bina Bhakti adalah strategi pembelajaran aktif, menarik, efektif untuk meningkatkan minat serta motivasi belajar peserta didik.
Pantoum as Transactional Communication Tactic in Lok Baintan Floating Market
Authors: Ayu Hamdani  , Latifa Ramonita  , Dewi Rachmawati  
Published: July 2024

The Lok Baintan Floating Market in South Kalimantan, is a unique tourist destination where local residents have been trading goods on the water for hundreds of years. The people there have been buying and selling on the Lok Baintan River since ancient times, previously using a barter system. One noteworthy feature of vendors' conduct at the market is their frequent utilization of pantoum as a tactic to enhance the interest of visitors. From a tourism perspective, this is an interesting and unique place to visit. With reference to transactional communication theory, this study intends to find out the tactics used by the vendors in the Floating Market when utilizing pantoum. Methodology research to gather as much information as possible about the issue, this study employs the qualitative research approach through document analysis and deep interviewing to relevant informants, consist of 10 informats, 5 Acil pantoum, 1 tourism government, 2 head of community and 2 visitors, The study's findings demonstrate that the utilization of pantoum in transactional communication at the Lok Baintan floating market benefits the vendors by providing a distinctive tourist attraction and thus, creating a chance for increased revenue and create good relationship. Not to mention, this practice might be seen as a means of maintaining a sustainable culture. As well this research shows an overview of how a rhyme culture can attract tourists and maintain a sustainable culture.
ANALISIS KEMAMPUAN PEMECAHAN MASALAH MATEMATIS MATERI POLA BILANGAN PADA SISWA KELAS VIII SMP KATOLIK AMBON
Authors: Hasan Salmawati , Ayal Carolina Selfisina , Rumalean Muhammad Samad 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui ada tidaknya perbedaan hasil belajar pesera didik dengan model pembelajaran kooperatif tipe Talking Stick berbantuan Question Card dan model pembelajaran kooperatif tipe Number Head Together (NHT) pada materi perbandingan trigonometri di kelas X SMK Negeri 2 Ambon. Jenis Penelitian yang digunakan adalah true experimental, dengan desain penelitian ini adalah Posttest-Only Control Design. Populasi dalam penelitian ini adalah seluruh peserta didik kelas X program keahlian akutansi dan keuangan (AK) yang terdiri dari dua kelas yang berjumlah 47 peserta didik. Sampel dalam penelitian ini menggunakan teknik sampling jenuh yaitu, kelas X.AK.1 yang diajarkan menggunakan model pembelajaran kooperatif tipe talking stick berbantuan question card yang berjumlah 24 peserta didik dan kelas X.AK.2 yang diajarkan menggunakan model pembelajaran koopertif tipe NHT yang berjumlah 23 peserta didik. Instrumen yang digunakan dalam penelitian ini berupa soal tes yang terdiri dari 4 soal urain. Teknik analisis yang digunakan adalah analisis statistik yaitu uji-t. Hasil penelitian yang diperoleh terdapat perbedaan hasil belajar peserta didik yang diajarkan menggunakan model pembelajaran kooperatif tipe Talking Stick berbantuan Question Card dan model pembelajaran Number Head Together pada materi perbandingan trigonometri. Hal ini terlihat dari hasil uji hipotesis menunjukan sig(2-tailed) < α, yaitu 0,045 < 0,05, sehingga terima H1 dan tolah H0.
ANALISIS PEMAHAMAN RELASIONAL DALAM MEMECAHKAN MASALAH SISTEM PERSAMAAN LINIER TIGA VARIABEL (SPLTV) DI KELAS X SMA NEGERI 7 AMBON
Authors: Linda Mey , Moma La , Huwaa Novalin Calasin 
Published: July 2024

Matematika merupakan ilmu universal yang dipelajari dari tingkat dasar hingga perguruaan tinggi. Salah satu hal yang diharapkan dari pembelajaran matematika adalah kemampuan peserta didik dalam pemahaman relasional. Dengan dimilikinya pemahaman tersebut peserta didik mampu mengenali bentuk soal baru, mampu membangun relasi antara unsur-unsur dalam masalah, mampu membangun relasi antara sifat atau struktur matematika yang telah dipelajari sebelumnya, mampu memecahkan masalah berdasarkan relasi yang telah dibangun. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Subjek dalam penelitian ini adalah 3 peserta didik yang dipilih dari 23 peserta didik dikelas X MIPA 1 SMA Negeri 7 Ambon. Hasil penelitian menunjukan bahwa peserta didik yang mampu menyelesaikan sebuah masalah SPLTV dan memiliki tahapan pemecahan masalah yang lengkap maka, akan memiliki juga pemahaman relasional yang lengkap. Hal tersebut berarti pemecahan masalah peserta didik berpengaruh pada pemahaman relasional yang dimilikinya.
Manajemen Komunikasi Dalam Menyosialisasikan Pencegahan Stunting Di Kecamatan Lebak Wangi Kabupaten Serang Tahun 2023
Authors: Syahputra Devin , Annisarizki Annisarizki , Mardiana Siska 
Published: July 2024

Masalah: Stunting merupakan penyakit kesehatan yang menyebabkan kegagalan tumbuh kembang kronis pada balita yang kebutuhan gizinya tidak tercukupi. Stunting juga menyebabkan kondisi kesehatan lain seperti gangguan intelektual, gangguan saraf motorik, dan gangguan kekebalan tubuh.

Tujuan: Penelitian ini bertujuan untuk mengetahui perencanaan, pengorganisasian, pelaksanaan dan evaluasi Kabupaten Lebak Wangi dalam mensosialisasikan pencegahan stunting.

Metodologi: Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Data penelitian ini diperoleh dari observasi dan wawancara 6 informan di Kecamatan Lebak Wangi.

Temuan/Hasil Penelitian: Hasil penelitian ini memberikan informasi mengenai perencanaan Kabupaten Lebak Wangi dalam sosialisasi pencegahan stunting yaitu loka karya mini atau koordinasi dengan pemangku dinas dalam rangka penguatan lintas sektor Lebak Wangi dalam pembahasan stunting dan melakukan penelitian terhadap peserta sosialisasi. pencegahan stunting. Pengorganisasian yaitu membentuk tim pemantau evaluasi, menentukan metode komunikasi langsung. Implementasinya meliputi pelaksanaan sosialisasi, implementasi program dapur sehat untuk mengatasi stunting, dan pemberian makanan tambahan serta menggunakann komunikasi tatap muka. Evaluasi yaitu lokakarya mini/koordinasi yang mempertemukan para pengurus di Wilayah Kabupaten Lebak Wangi yang dilaksanakan setiap 3 bulan sekali setelah pelaksanaan kegiatan sosialisasi pencegahan stunting dan tercapainya program sosialisasi pencegahan stunting.
HUBUNGAN RELIGIUSITAS DENGAN QUALITY OF LIFE PASIEN HEMODIALISA
Authors: Salsabila Cantika , Akbar Surya , Susanti Meri , Nasution Halimah Thania 
Published: July 2024

Penyakit kronis dapat mepengaruhi Quality of Life (QoL) seseorang. Salah satu kondisi penyakit kronis yang sering ditemukan adalah pasien dengan hemodialisa. Religiusitas dilain sisi dianggap dapat mempengaruhi kualitas hidup seseorang. Penelitian ini bertujuan untuk menganalisis hubungan antara tingkat religiusitas penderita hemodialisa dengan kualitas hidupnya. Desain penelitian ini adalah cross-sectional. Sebanyak 71 orang responden diambil dengan menggunakan teknik total sampling. Penderita hemodialisa di RSU Sembiring Deli Tua yang berjumlah 71 orang diambil sebagai responden pada penelitian ini. Pengumpulan data dilakukan dengan menggunakan kuesioner CRS 15 dan WHOQoL-BREF. Hasil data penelitian dianalisis menggunakan uji Spearman. Hasil penelitian didapatkan religiusitas responden tergolong tinggi yaitu 67 responden (94,4%). Seluruh responden memiliki Quality of Life tergolong baik. Uji korelasi religiusitas dengan QoL didapatkan hasil korelasi yang signifikan antara religiusitas dan QoL 0,014 (p<0,05). Berdasarkan analisis dimensi QoL, dimensi psikologis dan lingkungan berhubungan secara signifikan dengan tingkat religiusitas (p<0,05). Saran untuk peneliti lebih lanjut dapat memasukkan variabel lain yang mungkin berpengaruh terhadap QoL. Analisis multivariat diharapkan dapat dilakukan di penelitian selanjutnya agar dapat menggambarkan kondisi QoL secara lebih baik.
Validation of an Analytical Procedure for Evaluating the Biological Activity of a Medicinal Product Based on Tocilizumab and Determination of Acceptance Criteria for Test Results
Authors: Nikonova Yu. A. , Abbasova S. G. , Kargopolova P. E. , Strizhakova O. M. , Lyagoskin I. V. , Vasilev A. P. , Pershin A. S. 
Published: July 2024

INTRODUCTION. Bioanalytical techniques are characterised by greater variability and lower stability than physicochemical methods because live test systems are inherently labile. Since regulatory standards do not establish a unified approach, the selection of system suitability criteria and acceptance criteria for test results is based on validation studies.AIM. This study aimed to validate an analytical procedure for evaluating the biological activity of a medicinal product based on the investigational tocilizumab biosimilar GNR-087 and determine the quantitative limits for system suitability criteria and acceptance criteria for test results.MATERIALS AND METHODS. The biological activity of the investigational tocilizumab biosimilar was assessed by the inhibition of IL-6-induced secreted embryonic alkaline phosphatase (SEAP) expression by HEK-Blue™ IL-6 cells. Statistical processing of the obtained results was performed using Prism 6.0 software.RESULTS. The specificity of the analytical procedure was confirmed by the dose-dependent inhibition of IL-6-induced SEAP expression by cells observed with tocilizumab. The analytical procedure was linear, with a coefficient of determination R2≥ 0.99. The precision of the analytical procedure was satisfactory; its repeat ability varied from 2 to 9%, and its intermediate precision was 14%. The recovery coefficients (Rc) for spiked samples simulating activity levels of 60–140%, including blinded samples, ranged from 80 to 120%. The theoretical values of relative potency (RP) were within the confidence intervals of the mean relative potency estimates, which confirmed the accuracy of the analytical procedure. The validation confirmed the robustness of the analytical procedure to controlled variations, including the use of reporter cells at different passages (with a coefficient of variation for relative potency estimates (CVRP) of 10%), different IL-6 lots (with a CVRP of 1%), and different SEAP detection reagent lots (with a CVRP of 3%); the Rc remained in the range of 80–120% of the nominal RP value.CONCLUSIONS. The analytical procedure for evaluating the biological activity of the investigational tocilizumab biosimilar meets the validation criteria, including accuracy, linearity, precision, specificity, and robustness. The study established system suitability criteria and acceptable limits for biological assay results. This analytical procedure can be used both for routine biological activity control and for demonstrating the biosimilarity of new medicinal products to the original (reference) tocilizumab-based medicinal product.
Determination of Biological Activity of Gonadotrophins in Randombred and Sprague Dawley Rats. Part 2. Determination of Biological Activity of Luteinising Hormone
Authors: Batuashvili T. A. , Chechetova E. O. , Shadrin P. V. , Neugodova N. P. 
Published: July 2024

INTRODUCTION. The tendency towards reducing the use of laboratory animals in pharmaceutical quality assessment, along with the development of new technologies for gonadotrophin production, necessitate the development of novel assays to determine the biological activity of natural and recombinant anterior pituitary preparations.AIM. This study aimed to select the optimum conditions for the determination of the biological activity of luteinising hormone (LH) in urinary and genetically engineered LH preparations by tests in randombred and Sprague Dawley rats.MATERIALS AND METHODS. The biological activity of urinary and recombinant LH preparations was determined in vivo in a three-dose randomised Steelman–Pohley bioassay, which compared the biological activity of the test samples to a reference standard (RS). The analysis used two years’ worth of test results. The RS used was the WHO international standard containing 183 IU of follicle stimulating hormone bioactivity and 177 IU of LH bioactivity per ampoule. The bioassay was performed in immature male randombred and Sprague Dawley rats; the bioassay conditions were selected according to the rat type.RESULTS. The results of the in vivo determination of LH biological activity in male rats were compared by the standard deviation to slope ratio (s/b), which helps estimate response variation and dose dependence at the same time. The study demonstrated the possibility of using Sprague Dawley rats (s/b=0.82±0.44) for the determination of LH biological activity along with randombred animals (s/b=0.68±0.58). The s/b ratios were close, although Sprague Dawley rats and randombred rats were used in the assay at a 1:2 ratio.CONCLUSIONS. It is possible to determine the biological activity of LH from menopausal gonadotrophin preparations in both randombred and Sprague Dawley male rats. The use of Sprague Dawley rats for testing can confirm the reliability of test results using fewer animals than needed for standard tests; this is not only humane but also cost effective.
Basic Principles for Calculating the Required Number of Participants in Clinical Trials. Part 1. Common Approaches (Review)
Authors: Shreder O. V. , Goryachev D. V. , Merkulov V. A. 
Published: July 2024

INTRODUCTION. A well-planned design of a clinical trial (CT) ensures valid results in assessing the efficacy and safety of medicines for human use. However, at present, there are no clear criteria for selecting the basic elements underlying the development of a CT design. This lack of selection criteria primarily concerns planning research hypotheses, calculating the expected therapeutic effect, statistical significance level, and study power, and selecting statistical models for sample size calculation.AIM. The authors aimed to systematise and harmonise the technical requirements for sample size determination in designing CTs.DISCUSSION. First, this article describes the basic requirements for and methodological approaches to designing CTs to assess the efficacy of medicines and to confirm their safety. Next, the article presents the basic principles for calculating the sample size to ensure the required CT power. Finally, the article covers the mathematical models describing the null and alternative hypotheses used in the development of basic statistical designs for efficacy and safety studies. A general requirement for the quality of a study sample is to ensure its representativeness, that is, its compliance with the target CT population. The selection of a mathematical (probabilistic) model to formulate research hypotheses and calculate study samples representative of the target population is based on general data from systematic reviews of previous studies on the therapeutic effects of the study product and the specific characteristics of the target population. In addition, model selection relies on the classification of the study product. Sample size calculation requires defining and justifying certain criteria at the stage of CT design and statistical model development, in line with the general requirements for representativeness. Software for calculating the statistical power and required sample size facilitates routine CT planning.CONCLUSIONS. The sample size determination requires more than the application of basic statistical models. Given the multitude of CT designs and methodological approaches to CT planning, treatment regimens, and data collection and analysis, it is necessary to consider the statistical design of each CT on a case-by-case basis. This consideration should include assessments of individual cases, survival analysis methods, relative risks, diagnostic tests, and adaptive and other infrequent CT designs. The above highlights the need to develop additional guidelines and information resources that would explain and demonstrate the use of probabilistic statistics. The resulting national standards should be harmonised with international standards.
Recommendations for the Content of a Product Specification File: Water (Karl Fischer Method)
Authors: Vaganova O. A. , Natykan A. A. 
Published: July 2024

This article provides recommendations for documenting an analytical procedure for water determination by Karl Fischer titration in a product specification file (PSF). The article contains a description of specific aspects associated with the test and a template for the typical content and layout of the corresponding PSF section. A unified approach to the PSF content and layout will ensure error-free testing, reliable results, and streamlined regulatory assessments.