bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAKE BARNS AND FALSE DILEMMAS
Authors: Littlejohn Clayton 
Published: September 2014

AbstractThe central thesis of robust virtue epistemology (RVE) is that the difference between knowledge and mere true belief is that knowledge involves success that is attributable to a subject's abilities. An influential objection to this approach is that RVE delivers the wrong verdicts in cases of environmental luck. Critics of RVE argue that the view needs to be supplemented with modal anti-luck condition. This particular criticism rests on a number of mistakes about the nature of ability that I shall try to rectify here.
A new species ofParacomesoma(Comesomatidae) from Maldives (Indian Ocean) with an emended diagnosis and an updated key of the genus
Authors: Semprucci Federica 
Published: September 2014

A new species from the subfamily Comesomatinae is described from the back-reef platforms of the central part of the Maldivian archipelago.Paracomesoma susannaesp. nov. is characterized by a large-sized body, very long cephalic sensilla (72–91 µm long), lateral differentiation of punctuations, and, in the males, 19–22 minute precloacal supplements, relatively short spicules (2.3–2.9 anal body diameter) and a hook-like structure in the distal end of the gubernaculum.Paracomesoma susannaesp. nov. is the only species so far described of the genus which appears to have such a low ratio of the outer labial and cephalic sensilla (about 0.02). An emended diagnosis ofP. paralongispiculumis proposed, along with an updated and modified key to all the valid species of the genusParacomesoma.
Identification of human linear B-cell epitope sites on the envelope glycoproteins of Crimean-Congo haemorrhagic fever virus
Authors: GOEDHALS D. , PAWESKA J. T. , BURT F. J. 
Published: September 2014

SUMMARYA peptide library was used to screen for regions containing potential linear B-cell epitope sites in the glycoproteins and nucleoprotein of Crimean-Congo haemorrhagic fever virus (CCHFV) in an enzyme-linked immunosorbent assay (ELISA). The library consisted of 156 peptides, spanning the nucleoprotein and mature GNand GCproteins in a 19-mer with 9-mer overlap format. Using pooled serum samples from convalescent patients to screen the library, six peptides were identified as potential epitope sites. Further testing of these six peptides with individual patient sera identified two of these peptides as probable epitope sites, with peptide G1451–1469reacting to 13/15 and peptide G1613–1631to 14/15 human sera. These peptides are situated on the GCprotein at amino acid positions 1451–1469 (relative to CCHFV isolate SPU103/97) (TCTGCYACSSGISCKVRIH) and 1613–1631 (FMFGWRILFCFKCCRRTRG). Identified peptides may have application in ELISA for diagnostic or serosurveillance purposes.
Changes in health-related quality of life and quality of care among terminally ill cancer patients and survival prediction: Multicenter prospective cohort study
Authors: Lee Myung Kyung , Lee Woo Jin , Do Young Rok , Lee Keun Seok , Jung Kyung Hae , Heo Dae Seog , Kim Sam Yong , Park Sang Yoon , Jeong Hyun Sik , Kang Jung Hun , Kim Si-Young , Park Sook Ryun , Yun Young Ho 
Published: September 2014

AbstractObjective:This study examined changes in health-related quality of life (HRQoL) and quality of care (QoC) as perceived by terminally ill cancer patients and a stratified set of HRQoL or QoC factors that are most likely to influence survival at the end of life (EoL).Method:We administered questionnaires to 619 consecutive patients immediately after they were diagnosed with terminal cancer by physicians at 11 university hospitals and at the National Cancer Center in Korea. Subjects were followed up over 161.2 person-years until their deaths. We measured HRQoL using the core 30-item European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, and QoC using the Quality Care Questionnaire–End of Life (QCQ–EoL). We evaluated changes in HRQoL and QoC issues during the first three months after enrollment, performing sensitivity analysis by using data generated via four methods (complete case analysis, available case analysis, the last observation carried forward, and multiple imputation).Results:Emotional and cognitive functioning decreased significantly over time, while dyspnea, constipation, and pain increased significantly. Dignity-conserving care, care by healthcare professionals, family relationships, and QCQ–EoL total score decreased significantly. Global QoL, appetite loss, and Eastern Cooperative Oncology Group Performance Status (ECOG–PS) scores were significantly associated with survival.Significance of results:Future standardization of palliative care should be focused on assessment of these deteriorated types of quality. Accurate estimates of the length of life remaining for terminally ill cancer patients by such EoL-enhancing factors as global QoL, appetite loss, and ECOG–PS are needed to help patients experience a dignified and comfortable death.
Delirium in advanced age and dementia: A prolonged refractory course of delirium and lower functional status
Authors: Boettger Soenke , Jenewein Josef , Breitbart William 
Published: September 2014

AbstractObjective:The factors associated with persistent delirium, in contrast to resolved delirium, have not been studied well. The aim of our present study was to identify the factors associated with delirium resolution as measured by the Memorial Delirium Assessment Scale (MDAS) and functional improvement as measured by the Karnofsky Performance Status (KPS) scale.Method:All subjects were recruited from psychiatric referrals at the Memorial Sloan Kettering Cancer Center (MSKCC). The two study instruments were performed at baseline (T1), at 2–3 days (T2), and at 4–7 days (T3). Subjects with persistent delirium were compared to those with resolved delirium in respect to sociodemographic and medical variables.Results:Overall, 26 out of 111 patients had persistent delirium. These patients were older, predominantly male, and had more frequently preexisting comorbid dementia. Among cancer diagnoses and stage of illness, brain cancer and terminal illness contributed to persistent delirium or late response, whereas gastrointestinal cancer was associated with resolved delirium. Among etiologies, infection responded late to delirium management, usually at one week. Furthermore, delirium was more severe in patients with persistent delirium from baseline through one week. At baseline, MDAS scores were 20.1 in persistent delirium compared to 17 to 18.8 in resolved delirium (T2 and T3), and at one week of management (T3), MDAS scores were 15.2 and 4.7 to 7.4, respectively. At one week of management, persistent delirium manifested in more severe impairment in the domains of consciousness, cognition, organization, perception, psychomotor behavior, and sleep–wake cycle. In addition, persistent delirium caused more severe functional impairment.Significance of results:In this delirium sample, advanced age and preexisting dementia, as well as brain cancer, terminal illness, infection, and delirium severity contributed to persistent delirium or late response, indicating a prolonged and refractory course of delirium, in addition to more severe functional impairment through one week of management.
Magnetic nanoparticle-mediated isolation of functional bacteria in a complex microbial community
Authors: Zhang Dayi , Berry James P , Zhu Di , Wang Yun , Chen Yin , Jiang Bo , Huang Shi , Langford Harry , Li Guanghe , Davison Paul A , Xu Jian , Aries Eric , Huang Wei E 
Published: September 2014

Abstract
Although uncultured microorganisms have important roles in ecosystems, their ecophysiology in situ remains elusive owing to the difficulty of obtaining live cells from their natural habitats. In this study, we employed a novel magnetic nanoparticle-mediated isolation (MMI) method to recover metabolically active cells of a group of previously uncultured phenol degraders, Burkholderiales spp., from coking plant wastewater biosludge; five other culturable phenol degraders—Rhodococcus sp., Chryseobacterium sp. and three different Pseudomonas spp.—were also isolated from the same biosludge using traditional methods. The kinetics of phenol degradation by MMI-recovered cells (MRCs) was similar to that of the original sludge. Stable isotope probing (SIP) and pyrosequencing of the 16S rRNA from the ‘heavy’ DNA (13C-DNA) fractions indicated that Burkholderiales spp. were the key phenol degraders in situ in the biosludge, consistent with the results of MRCs. Single-cell Raman micro-spectroscopy was applied to probe individual bacteria in the MRCs obtained from the SIP experiment and showed that 79% of them were fully 13C-labelled. Biolog assays on the MRCs revealed the impact of various carbon and nitrogen substrates on the efficiency of phenol degradation in the wastewater treatment plant biosludge. Specifically, hydroxylamine, a metabolite of ammonia oxidisation, but not nitrite, nitrate or ammonia, inhibited phenol degradation in the biosludge. Our results provided a novel insight into the occasional abrupt failure events that occur in the wastewater treatment plant. This study demonstrated that MMI is a powerful tool to recover live and functional cells in situ from a complex microbial community to enable further characterisation of their physiology.
[NiFe]-hydrogenase maturation in vitro: analysis of the roles of the HybG and HypD accessory proteins
Authors: Soboh Basem , Lindenstrauss Ute , Granich Claudia , Javed Mahwish , Herzberg Martin , Thomas Claudia , Stripp Sven T. 
Published: September 2014

[NiFe]-hydrogenases (Hyd) bind a nickel-iron-based cofactor. The Fe ion of the cofactor is bound by two cyanide ligands and a single carbon monoxide ligand. Minimally six accessory proteins (HypA–HypF) are necessary for NiFe(CN)2CO cofactor biosynthesis in Escherichia coli. It has been shown that the anaerobically purified HypC–HypD–HypE scaffold complex carries the Fe(CN)2CO moiety of this cofactor. In the present study, we have purified the HybG–HypDE complex and used it to successfully reconstitute in vitro active Hyd from E. coli. HybG is a homologue of HypC that is specifically required for the maturation of Hyd-2 and also functions in the maturation of Hyd-1 of E. coli. Maturation of active Hyd-1 and Hyd-2 could be demonstrated in extracts derived from HybG- and HypD-deficient E. coli strains by adding anaerobically purified HybG–HypDE complex. In vitro maturation was dependent on ATP, carbamoylphosphate, nickel and reducing conditions. Hydrogenase maturation was prevented when the purified HybG–HypDE complex used in the maturation assay lacked a bound Fe(CN)2CO moiety. These findings demonstrate that it is possible to isolate incompletely processed intermediates on the maturation pathway and to use these to activate apo-forms of [NiFe]-hydrogenase large subunits.
The crystal structure of the RhoA–AKAP-Lbc DH–PH domain complex
Authors: Abdul Azeez Kamal R. , Knapp Stefan , Fernandes João M. P. , Klussmann Enno , Elkins Jonathan M. 
Published: September 2014

The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. We have determined the X-ray crystal structure of the complex between RhoA–GDP and the AKAP-Lbc RhoGEF [DH (Dbl-homologous)–PH (pleckstrin homology)] domain to 2.1 Å (1 Å=0.1 nm) resolution. The structure reveals important differences compared with related RhoGEF proteins such as leukaemia-associated RhoGEF. Nucleotide-exchange assays comparing the activity of the DH–PH domain to the DH domain alone showed no role for the PH domain in nucleotide exchange, which is explained by the RhoA–AKAP-Lbc structure. Comparison with a structure of the isolated AKAP-Lbc DH domain revealed a change in conformation of the N-terminal ‘GEF switch’ region upon binding to RhoA. Isothermal titration calorimetry showed that AKAP-Lbc has only micromolar affinity for RhoA, which combined with the presence of potential binding pockets for small molecules on AKAP-Lbc, raises the possibility of targeting AKAP-Lbc with GEF inhibitors.
Modelling and validation of a simple and compact wide upper stop band ultra‐wideband bandpass filter
Authors: Roy Choudhury Somdotta , Das Santanu 
Published: September 2014

A compact ultra‐wideband (UWB) bandpass filter (BPF) is proposed based on end coupled microstrip transmission line, defected ground structure and defected microstrip structure. The experimental filter shows a fractional bandwidth of 110% at a centre frequency, with two observable transmission zeros (attenuation poles) at 2.1 and 11.7 GHz. Measured results exhibit an UWB passband from 3.02 to 10.6 GHz with mid‐band insertion loss of 1.8 dB and group delay variation <0.45 ns. The BPF achieves a wide stopband with < −18 dB attenuation up to 20 GHz.
The feasibility and appeal of mobile ‘apps’ for supporting healthy food purchasing and consumption among socioeconomically disadvantaged women: a pilot study
Authors: Ball Kylie , Mouchacca Jennifer , Jackson Michelle 
Published: September 2014

AimThis pilot study aimed to assess the feasibility and appeal of using existing hand‐held mobile technology (iPod or iPad) ‘apps’ as tools promoting healthy food planning, shopping and eating behaviours among socioeconomically disadvantaged women.MethodsSurveys were administered before and immediately after a 4‐week trial of seven currently available iPod or iPad apps, each of which addressed known barriers to healthy eating among socioeconomically disadvantaged women. A convenience sample was recruited from a local community in Melbourne, Australia, comprising 19 women with a low education (fewer than 12 years of formal education) or a low income (a household income of less than $1000 per week, and/or having a pension or benefit as the main source of income).ResultsMore than half of the sample (n = 11, 61%) used most apps at least weekly over the study period. Few found any of the apps complex or difficult to use, and most (n = 14) reported that they would use their preferred apps again. Features liked included portability, simplicity, user‐friendliness, and novelty/new knowledge provided by certain apps; less appealing features included requirements for time‐consuming data entry and inability to access features offline.ConclusionsSelected iPod and iPad apps are useable and appealing to socioeconomically disadvantaged women. Particular features of apps, including simplicity of use and providing seasonal information, appear helpful in assisting women to plan, shop and consume healthy foods.So what?This study demonstrates a promising approach for reaching and engaging socioeconomically disadvantaged target populations in healthy eating, through the use of mobile apps. Further research establishing the effectiveness of these apps in promoting healthy food planning, shopping and eating behaviours is now warranted.
Stop codas in Old Chinese and Proto Sino-Tibetan
Authors: Song Chenqing 
Published: September 2014

Reconstruction studies of Old Chinese (OC hereafter) and Proto Sino-Tibetan (PST hereafter) have yielded numerous significant discoveries related to the phonological histories of these two ancient languages. Despite recent advancements into OC and PST phonological histories, a few mysteries remain yet unsolved. One such mystery, the ‘stop coda’ problem, is as hotly debated now as it was when it was first raised seventy years ago. This long-running debate focuses on the existence and identity of the ‘stop codas’ in OC and in its parent language, PST. One reason why this debate has failed to reach a satisfactory conclusion is that the reconstruction methodology is limited, which assumes the Neogrammarian law of sound change. This law holds that sound change occurs without exception in every form that meets the structural description. Although this law applies to many sound changes in myriad world languages, it is not the only possible pathway of sound change. In this paper, I will argue that the key to the ‘stop-coda’ problem of OC belongs to another sound change type — lexical diffusion.The organization of the paper is as follows. In Part One, I will introduce the background of the debate over the ‘stop codas’ in OC. Part Two reviews previous opposing analyses of the ‘stop coda’ debate. Part Three details my proposal for a lexical diffusion analysis of the ‘stop coda’ problem based on internal evidence in Chinese. Part Four investigates the problem using the Comparative Method based on external evidence from Tibetan and loan words from Chinese to Sino-Japanese. In Part Five, I will present my solution to the ‘stop coda’ problem, which is based on the analysis in the two preceding sections. Finally, in Part Six, I will discuss the general methodology of phonological reconstruction in light of the sound change mechanism.
Modelling and forecasting stock–recruitment: current and future perspectives
Authors: Subbey Sam , Devine Jennifer A. , Schaarschmidt Ute , Nash Richard D.M. 
Published: September 2014

AbstractThis paper presents a brief review of the present state of knowledge in stock–recruitment forecasting, including process and current methodological challenges to predicting stock–recruitment. The discussion covers the apparent inability of models to accurately forecast recruitment even when environmental covariates are included as explanatory variables. The review shows that despite the incremental success in the past hundred years, substantial challenges remain if the process of modelling and forecasting stock–recruitment is to become relevant to fisheries science and management in the next 100 years.
Religion and Sexuality
Authors: Adams James Eli 
Published: September 2014

Abstract
Victorian sexual attitudes were closely bound up with the impact of Evangelical faith, particularly as it informed two subsequent developments in Victorian Christianity: Tractarianism, which was widely received as a form of Anglo-Catholicism, and ‘muscular Christianity’, which was centrally concerned to rescue the body from the moral rigour of both Evangelicals and Tractarians. In religious controversy, connections between sexuality and faith emerge not only in direct address of central concerns, such as marriage and prostitution, but more obliquely, through the labelling of deviance, particularly the insinuation of ‘unnatural’ desire. Such stigma gave unusual public notice to, or at least glimpses of, proscribed forms of sexuality, which came into increasing visibility in the latter decades of the century, partly through appeals to ancient Greece as the source of a more humane ethos than Christianity.
Religion, the Bible, and Literature in the Victorian Age
Authors: Mason Emma 
Published: September 2014

Abstract
This chapter locates religion at the heart of Victorian literary culture and explores the reciprocal relationship between literary and religious forms, texts, and aesthetics. After outlining the relationship between literature and religion in the period, the chapter reflects on how modern criticism reads this relationship, both historically and philosophically. Suggesting that new historicism and cultural formalism are sometimes methodologically limited in assessing the experiential and immaterial aspects of the literature and religion debate, the chapter asks how criticism might rethink it. Theopoetics and the affective turn are offered as possible ways into the debate, as is the non-dualist approach of Martin Heidegger. Heidegger’s emphasis on care through patient and communal reading forms the basis of what the chapter calls pastoralism, a compassionate and discerning mode of reading attuned to a Victorian perception of ‘love’, ‘spirit’, ‘faith’, and ‘grace’ through religious discourse.
Literature and the Expansion of the Press
Authors: Shattock Joanne 
Published: September 2014

Abstract
This chapter traces the growth of the periodical press from the mid-nineteenth century until the end of the Victorian period, emphasizing the explosion in the number of weekly and monthly publications that serialized fiction. It demonstrates the interconnections between the professionalization of authorship in the Victorian period and the buoyant periodical press. The editorship of a weekly or monthly magazine was a role undertaken by a number of writers, providing a regular income in addition to fees earned from individual works. Poets too profited from publication in magazines, but it was mainly novelists, whose works often first appeared in weeklies and monthlies and who combined reviewing the work of others with creative writing at some point in their careers, who benefited most from the press. Writers discussed include Dickens, Elizabeth Gaskell, George Eliot, Margaret Oliphant, and Tennyson.
‘You’ve Got Mail’
Authors: Meadows Elizabeth , Clayton Jay 
Published: September 2014

Abstract
Although the Victorian period gave birth to a strong tradition of critique of technology and industrialization, it also fostered a counter-tradition: a new and generative technological imaginary. In recent years, scholars of Victorian culture have begun to map out this technological imaginary in readings of canonical Victorian novels by Charles Dickens, George Eliot, and Elizabeth Gaskell. This chapter surveys this recent critical work, then turns to Anthony Trollope’s The Small House at Allington (1864) as an example of how technologies of communication and transportation become vehicles for rich intersubjective exchanges, generating narrative structures that link characters and novels to one another in complex webs mimicking Victorian Britain’s network of rails, wires, and postal routes.
Celebrity Culture
Authors: Plunkett John 
Published: September 2014

Abstract
The Victorian period saw the power and mystique of ‘celebrity’ become an established part of cultural life. Authors were both subjects and objects of a celebrity culture that were equally evident in theatre, music, painting, fashion, and the sporting world. Victorian celebrity marks the democratization of the public sphere but at the same time its advent is infused by a commercial dynamic, making it more liable to fabrication and an inherent transience. Numerous factors coalesced between 1780 and 1830 to form the recognizable dynamics of modern celebrity and publicity culture. The commercial development of the newspaper and periodical press, coupled with the advent of media like photography, provided a host of new ways for writers like Charles Dickens and Oscar Wilde to interact with readers, overcoming, or perhaps disavowing, their own commodification in order to make a genuine psychological and affective connection with them.
Numerical Cognition during Cognitive Aging
Authors: Uittenhove Kim , Lemaire Patrick 
Published: September 2014

AbstractThis chapter provides an overview of age-related changes and stabilities in numerical cognition. For each component (i.e. approximate and exact number system, quantification, and arithmetic) of numerical cognition, we review changes in participants’ performance during normal and pathological aging in a wide variety of tasks (e.g. number comparison, subitizing, counting, and simple or complex arithmetic problem-solving). We discuss both behavioral and neural mechanisms underlying these performance variations. Moreover, we highlight the importance of taking into account strategic variations. Indeed, investigating strategy repertoire (i.e. how young and older adults accomplish numerical cognitive tasks), selection (i.e. how participants choose strategies on each problem), execution (i.e. how strategies are implemented once selected), and distribution (i.e. how often participants use each available strategy) enables to determine sources of aging effects and individual differences in numerical cognition. Finally, we discuss potential future research to further our understanding of age-related changes in numerical cognition.