bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Explorations of New Second‐Order Nonlinear Optical Materials in the Ternary Rubidium Iodate System: Noncentrosymmetric β‐RbIO3(HIO3)2 and Centrosymmetric Rb3(IO3)3(I2O5) (HIO3)4(H2O).
Authors: Xu Xiang , Yang Bing‐Ping , Huang Chao , Mao Jiang‐Gao 
Published: March 2014

AbstractThe structures of the new compounds (III) and (IV) are determined by single crystal XRD.
ChemInform Abstract: Synthesis, Crystal and Electronic Structure of the Quaternary Magnetic EuTAl4Si2 (T= Rh and Ir) Compounds.
Authors: Maurya Arvind , Thamizhavel Arumugam , Provino Alessia , Pani Marcella , Manfrinetti Pietro , Paudyal Durga , Dhar Sudesh Kumar 
Published: March 2014

AbstractSingle crystals of the title compounds are prepared from the elements using an eutectic Al—Si mixture as a flux (alumina crucible, 1100 °C, 24 h).
ChemInform Abstract: A Novel Organocatalytic Asymmetric Transfer Hydrogenation of α,β‐Unsaturated Aldehydes.
Authors: Zhang Bao‐Hua , Shi Lan‐Xiang , Guo Rui‐Xia 
Published: March 2014

Abstractα,β‐Unsaturated aldehydes (I) react with diimide in the presence of an optically active ammonium salt as catalyst to give the corresponding saturated aldehydes (II) in high yields and enantioselectivities.
ChemInform Abstract: Thermolysis of Trifluoromethyl‐Containing Vinyldiazocarbonyl Compounds and X‐Ray Crystal Structure Analysis of Unexpected Reaction Products.
Authors: Nikolaev Valerij A. , Supurgibekov Murat B. , Haiges Ralf , Linden Anthony , Prakash G. K. Surya 
Published: March 2014

AbstractThermolysis of the title compounds results in the formation of different products due to different pathways of decomposition.
ChemInform Abstract: Nucleophilic Substitution of Azide Acting as a Pseudo Leaving Group: One‐Step Synthesis of Various Aza Heterocycles.
Authors: Doebelin Christelle , Schmitt Martine , Antheaume Cyril , Bourguignon Jean‐Jacques , Bihel Frederic 
Published: March 2014

AbstractIt is found that 3‐azidopropanoic acid reacts with carbodiimides to afford a six‐membered ring intermediate.
ChemInform Abstract: Metal‐Free Carbonitration of Alkenes Using K2S2O8.
Authors: Li Ya‐Min , Wei Xiao‐Hong , Li Xi‐An , Yang Shang‐Dong 
Published: March 2014

AbstractA novel metal‐free oxidative carbonitration of alkenes (I) and (III) by a nitration and C—H functionalization cascade process is reported.
ChemInform Abstract: Chiral Hybrid Inorganic—Organic Materials: Synthesis, Characterization, and Application in Stereoselective Organocatalytic Cycloadditions.
Authors: Puglisi Alessandra , Benaglia Maurizio , Annunziata Rita , Chiroli Valerio , Porta Riccardo , Gervasini Antonella 
Published: March 2014

AbstractThe chiral imidazolidinone (SMI) immobilized on mesoporous silica nanoparticles, efficiently promotes the asymmetric cycloaddition of unsaturated aldehydes to cyclopentadiene.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Coupling of Aromatic Primary Amines and Alkenes under Molecular Oxygen: Stereoselective Assembly of (Z)‐Enamines.
Authors: Ji Xiaochen , Huang Huawen , Wu Wanqing , Li Xianwei , Jiang Huanfeng 
Published: March 2014

AbstractThe title reaction allows an efficient, highly regio‐ and stereoselective access to aromatic (Z)‐enamines.
ChemInform Abstract: Synthesis of Enantioenriched Tertiary Boronic Esters by the Lithiation/Borylation of Secondary Alkyl Benzoates.
Authors: Pulis Alexander P. , Blair Daniel J. , Torres Eva , Aggarwal Varinder K. 
Published: March 2014

AbstractUnactivated secondary Tib esters react to afford a range of neopentyl boronic esters, which are transformed to the corresponding tertiary alcohols in high yields and generally high enantioselectivities.
ChemInform Abstract: Ruthenium‐ and Rhodium‐Catalyzed Oxidative Alkylation of C—H Bonds: Efficient Access to β‐Aryl Ketones.
Authors: Qi Ji , Huang Liangbin , Wang Zhaoyang , Jiang Huanfeng 
Published: March 2014

AbstractA Ru‐catalyzed amide‐directed C—H alkylation and a Rh‐catalyzed pyridine‐ or pyrimidine‐directed C—H alkylation of arenes with allylic alcohols (II) and (V) is reported.
ChemInform Abstract: Selective Catalytic Oxidation of Alcohols, Aldehydes, Alkanes and Alkenes Employing Manganese Catalysts and Hydrogen Peroxide.
Authors: Saisaha Pattama , Buettner Lea , van der Meer Margarethe , Hage Ronald , Feringa Ben L. , Browne Wesley R. , de Boer Johannes W. 
Published: March 2014

AbstractOxidation of a wide range of organic substrates to ketones or carboxylic acids is developed using aqueous hydrogen peroxide in the presence of a binary Mn‐complex as a catalyst and carboxylic acids as a co‐catalyst.
ChemInform Abstract: Radical Migration—Addition of N‐tert‐Butanesulfinyl Imines with Organozinc Reagents.
Authors: Huang Wei , Ye Jian‐Liang , Zheng Wei , Dong Han‐Qing , Wei Bang‐Guo 
Published: March 2014

AbstractThe reaction of tert‐butanesulfinyl iminoacetate (Ia) with benzyl zinc bromides results in unusual formation of migration—addition products without any catalyst.
ChemInform Abstract: Rhodium(III)‐Catalyzed Direct Regioselective Synthesis of 7‐Substituted Indoles.
Authors: Song Zengqiang , Samanta Rajarshi , Antonchick Andrey P. 
Published: March 2014

AbstractAn efficient, atom‐economic one‐pot method is developed for the preparation of 7‐substituted indoles via rhodium(III)‐catalyzed oxidative cross‐coupling.
ChemInform Abstract: Enantioselective Organocatalytic Addition of Nitroalkanes to Oxindolylideneindolenines for the Construction of Chiral 3,3‐Disubstituted Oxindoles.
Authors: Huang Jian‐Zhou , Wu Xiang , Gong Liu‐Zhu 
Published: March 2014

AbstractThe title addition reaction proceeds in the presence of a cinchona‐derived urea as the optically active catalyst to give 3,3‐disubstituted oxindoles in high yields and excellent enantioselectivties.
ChemInform Abstract: Reaction of 3‐Arylhydrazono‐3H‐furan‐2‐ones with o‐Phenylenediamine.
Authors: Maiorova O. A. , Egorova A. Yu. 
Published: March 2014

AbstractThe title reaction results in the formation of pyrazolyl‐benzimidazoles (III) or benzopyrroloimidazolones (IV) depending on the reaction conditions.
ChemInform Abstract: An Improved Protocol for Synthesis of N‐Arylamides and Benzoxazoles by the Copper‐Catalyzed Reaction of Aryl Halides with Nitriles.
Authors: Zhang Dong‐Xue , Xiang Shi‐Kai , Hu Hao , Tan Wen , Feng Chun , Wang Bi‐Qin , Zhao Ke‐Qing , Hu Ping , Yang Hua 
Published: March 2014

AbstractAtom‐efficient and environmentally benign syntheses of title amides [(III) and (V)] and benzoxazoles [(VII) and (IX)] are accomplished by an improved protocol using acetaldoxime instead of H2O as hydrolysis agent to facilitate the operation of the reaction.
ChemInform Abstract: Controllable Synthesis of Bis(1,2,3‐triazole)s and 5‐Alkynyl‐triazoles via Temperature Effect on Copper‐Catalyzed Huisgen Cycloaddition.
Authors: Li Lingjun , Fan Xincui , Zhang Yang , Zhu Anlian , Zhang Guisheng 
Published: March 2014

AbstractAlkynyltriazoles and bis‐triazoles including nucleoside analogues are prepared under different reaction temperatures.
ChemInform Abstract: H6P2W18O62·18H2 O: A Green and Reusable Catalyst for One‐Pot Synthesis of Pyrano[4,3‐b]pyrans in Water
Authors: Rajguru Deepika , Keshwal Balwant S. , Jain Shubha 
Published: March 2014

Abstractvia a one‐pot three‐component reaction
ChemInform Abstract: Arylation of Pyridines via Suzuki—Miyaura Cross‐Coupling and Pyridine‐Directed C—H Activation Using a Continuous‐Flow Approach.
Authors: Christakakou Maria , Schoen Michael , Schnuerch Michael , Mihovilovic Marko D. 
Published: March 2014

AbstractSuzuki—Miyaura coupling and arylation reactions of 2‐phenylpyridine are performed by using continuous flow conditions.
ChemInform Abstract: Synthesis of Isoquinoline Derivatives Through Rhodium(III)‐Catalyzed Reactions of Benzylamines with Non‐Terminal Alkynes.
Authors: Kim Dong‐Su , Park Jung‐Woo , Jun Chul‐Ho 
Published: March 2014

AbstractThe Rh(III)‐catalyzed N‐annulation of primary, secondary, and tertiary benzylamines with internal alkynes is developed.
ChemInform Abstract: A Novel and Convenient Strategy for the Synthesis of Phthalazines from an Aryne Precursor.
Authors: Bel Abed Hassen , Bande Omprakash , Mammoliti Oscar , Van Lommen Guy , Herdewijn Piet 
Published: March 2014

AbstractThe novel three‐step synthesis for the synthesis of phthalazines involves direct acyl‐alkylation of in situ generated arynes, azide transfer reaction and Diaza‐Wittig reaction.
ChemInform Abstract: Synthesis of Pyrido[2,1‐a]isoquinolin‐4‐ones and Oxazino[2,3‐a]isoquinolin‐4‐ones: New Inhibitors of Mitochondrial Respiratory Chain.
Authors: Moreno Laura , Cabedo Nuria , Boulange Agathe , Parraga Javier , Galan Abraham , Leleu Stephane , Sanz Maria‐Jesus , Cortes Diego , Franck Xavier 
Published: March 2014

AbstractMost of the new compounds are able to inhibit mitochondrial respiratory chain.
ChemInform Abstract: Synthesis and in vitro/in vivo Antibacterial Activity of Oxazolidinones Having Thiocarbamate at C‐5 on the A‐Ring and an Amide‐ or Urea‐Substituted [1,2,5]Triazepane or [1,2,5]Oxadiazepane as the C‐Ring.
Authors: Suzuki Hideyuki , Utsunomiya Iwao , Shudo Koichi , Fukuhara Norio , Iwaki Tsutomu , Yasukata Tatsuro 
Published: March 2014

AbstractOxazolidinones (Vb), (VII), and (IX) show 2‐ to 3‐fold greater antibacterial activities against Gram‐positive, Gram‐negative and linezolid‐resistent pathogens than linezolid in a systemic mouse infection model.
ChemInform Abstract: Unexpected Insertion of CO2 into the Pentacoordinate P—N Bond: Atherton—Todd‐Type Reaction of Hydrospirophosphorane with Amines.
Authors: Cao Shuxia , Gao Peng , Guo Yanchun , Zhao Huamin , Wang Jun , Liu Yifan , Zhao Yufen 
Published: March 2014

AbstractBase‐mediated treatment of hydrospirophosphoranes with secondary amines results in the formation of phosphorane carbamates via unexpected CO2 insertion.
ChemInform Abstract: An Expedient Ultrasonic Assisted One‐Pot Four Component Synthesis of Novel Ferrocene Grafted Pyrrolidine Heterocycles via [3 + 2]‐Cycloaddition of Azomethine Ylides.
Authors: Babu A. R. Suresh , Gavaskar D. , Raghunathan R. 
Published: March 2014

AbstractSequential heterocyclization of ninhydrin with phenylenediamine, condensation with sarcosine, and thermal decarboxylation provides an azomethine ylide intermediate.
ChemInform Abstract: Structurally Diverse Hamigerans from the New Zealand Marine Sponge Hamigera tarangaensis: NMR‐Directed Isolation, Structure Elucidation and Antifungal Activity.
Authors: Singh A. Jonathan , Dattelbaum Jonathan D. , Field Jessica J. , Smart Zlatka , Woolly Ethan F. , Barber Jacqueline M. , Heathcott Rosemary , Miller John H. , Northcote Peter T. 
Published: March 2014

AbstractAll new hamigerans exhibit micromolar activitiy towards the promyelocytic leukaemic cell line HL60.
ChemInform Abstract: Lanostane Triterpenes from Ceriporia lacerate HS‐ZJUT‐C13A, a Fungal Endophyte of Huperzia serrata
Authors: Ying You‐Min , Shan Wei‐Guang , Zhang Li‐Wen , Chen Yan , Zhan Zha‐Jun 
Published: March 2014

Abstractisolation and structure elucidation of two new lanostane triterpenes (I) and (II) along with four known analogs
ChemInform Abstract: Synthesis and Cytotoxic Activity of Some Novel Steroidal C‐17 Pyrazolinyl Derivatives.
Authors: Fan Ning‐Juan , Tang Jiang‐Jiang , Li He , Li Xiao‐Jun , Luo Bo , Gao Jin‐Ming 
Published: March 2014

AbstractSome of the synthesized compounds (III) (14 examples) exhibit significant cytotoxic activities.
Simplified Silvestrol Analogues with Potent Cytotoxic Activity
Authors: Hawkins Bill C. , Lindqvist Lisa M. , Nhu Duong , Sharp Phillip P. , Segal David , Powell Andrew K. , Campbell Michael , Ryan Eileen , Chambers Jennifer M. , White Jonathan M. , Rizzacasa Mark A. , Lessene Guillaume , Huang David C. S. , Burns Christopher J. 
Published: March 2014

AbstractThe complex natural products silvestrol (1) and episilvestrol (2) are inhibitors of translation initiation through binding to the DEAD‐box helicase eukaryotic initiation factor 4A (eIF4A). Both compounds are potently cytotoxic to cancer cells in vitro, and 1 has demonstrated efficacy in vivo in several xenograft cancer models. Here we show that 2 has limited plasma membrane permeability and is metabolized in liver microsomes in a manner consistent with that reported for 1. In addition, we have prepared a series of analogues of these compounds where the complex pseudo‐sugar at C6 has been replaced with chemically simpler moieties to improve drug‐likeness. Selected compounds from this work possess excellent activity in biochemical and cellular translation assays with potent activity against leukemia cell lines.
Impact of the accuracy of automatic segmentation of cell nuclei clusters on classification of thyroid follicular lesions
Authors: Jung Chanho , Kim Changick 
Published: March 2014

AbstractAutomatic segmentation of cell nuclei clusters is a key building block in systems for quantitative analysis of microscopy cell images. For that reason, it has received a great attention over the last decade, and diverse automatic approaches to segment clustered nuclei with varying levels of performance under different test conditions have been proposed in literature. To the best of our knowledge, however, so far there is no comparative study on the methods. This study is a first attempt to fill this research gap. More precisely, the purpose of this study is to present an objective performance comparison of existing state‐of‐the‐art segmentation methods. Particularly, the impact of their accuracy on classification of thyroid follicular lesions is also investigated “quantitatively” under the same experimental condition, to evaluate the applicability of the methods. Thirteen different segmentation approaches are compared in terms of not only errors in nuclei segmentation and delineation, but also their impact on the performance of system to classify thyroid follicular lesions using different metrics (e.g., diagnostic accuracy, sensitivity, specificity, etc.). Extensive experiments have been conducted on a total of 204 digitized thyroid biopsy specimens. Our study demonstrates that significant diagnostic errors can be avoided using more advanced segmentation approaches. We believe that this comprehensive comparative study serves as a reference point and guide for developers and practitioners in choosing an appropriate automatic segmentation technique adopted for building automated systems for specifically classifying follicular thyroid lesions. © 2014 International Society for Advancement of Cytometry
Sodium “Activation” of Silano‐Phosphonate Modified Mesoporous TiO2 Leading to Improved Rare‐Earth Element Extraction
Authors: Moloney Mícheál P. , Causse Jérémy , Loubat Cedric , Grandjean Agnès 
Published: March 2014

AbstractDue to their presence in most modern electronic devices and as waste products in the nuclear cycle, a great deal of interest has been generated in the acquisition and/or recycling/removal of rare‐earth elements (REE). Here, we present a simple one‐pot route for the preparation of dimethylphosphatoethyltriethoxysilane (SiP) functionalised mesoporous TiO2 particles. The resistance of TiO2 to strong bases allowed for the use of NaOH to “activate” the phosphonate head group of the functionality, significantly improving its efficiency. Levels of 92.6 mg/g Ce3+ were extracted from water, which is double the previously reported value for the extraction of REEs with this type of extractant. SiP‐TiO2 (Na) was also used to separate completely the Ce3+ from aqueous solutions containing Sr2+ and Cs+. Finally, the nanocomposite separated Ce3+ from other homovalent REEs, for example, Yb3+ (1:1.4 separation ratio).
Selective Suzuki–Miyaura Monocouplings with Symmetrical Dibromoarenes and Aryl Ditriflates for the One‐Pot Synthesis of Unsymmetrical Triaryls
Authors: Minard Corinne , Palacio Carole , Cariou Kevin , Dodd Robert H. 
Published: March 2014

AbstractThe various parameters that would permit selective Suzuki–Miyaura monocouplings of symmetrical dihaloarenes were studied. High selectivity and efficiency can be obtained for a broad range of substrates by using operationally simple conditions and widely available reagents. The 38 different examples described provide a valuable toolbox for the rapid access to unsymmetrical triaryls, as illustrated by the preparation of diarylpyridine 8, terphenyl 9, and diarylpyrrole 10.
Facile Formation of Methylenebis(chalcone)s through Unprecedented Methylenation Reaction. Application to Antiparasitic and Natural Product Synthesis
Authors: Thévenin Marion , Mouray Elisabeth , Grellier Philippe , Dubois Joëlle 
Published: March 2014

AbstractThe formation of methylenebis(chalcone)s has been discovered during deprotection with methoxymethyl groups from trihydroxychalcones. Studies on this methylenation reaction led to a mechanism hypothesis that was extended to other chalcones and to dihydrochalcone, acetophenone, benzophenone and flavone derivatives. This new method was applied to the rapid synthesis of natural product piperanduncin C. These original methylenebis compounds were also evaluated for their antiparasitic activity.
O‐Trifluoromethylation of N,N‐Disubstituted Hydroxylamines with Hypervalent Iodine Reagents
Authors: Matoušek Václav , Pietrasiak Ewa , Sigrist Lukas , Czarniecki Barbara , Togni Antonio 
Published: March 2014

AbstractA mild trifluoromethylation reaction of N,N‐disubstituted hydroxylamines that is tolerant towards a variety of functional groups, including nitriles, alcohols, ketones, esters, amides, imides, and nitrogen heterocycles, is reported. The key feature of this reaction is the activation of the CF3 reagent with either trimethylsilyl triflate or LiClO4 and partial or full deprotonation of the substrate with tetramethylguanidine or lithium diisopropylamide. Products were obtained in up to 80 % yield. Preliminary mechanistic studies suggested that the reaction follows a radical pathway in which the deprotonated hydroxylamine and a Lewis or Brønsted acid activated CF3 reagent engages in a single‐electron‐transfer step to generate a pair of radicals that recombine to afford the desired product. The trifluoromethylation procedure was successfully used in the modification of secondary nitrogen groups of pharmaceutically relevant targets (Fluoxetine and Mefloquine), which afforded new derivatives containing a novel N‐trifluoromethoxy moiety.
Li2−xFe1−xAlxSiO4/C Nanocomposites Cathodes for Lithium‐Ion Batteries
Authors: Gao Hai‐yan , Hu Zhe , Yang Jin‐gang , Chen Jun 
Published: March 2014

AbstractRecently, Li2FeSiO4 has been identified as one of the most attractive cathode materials for lithium‐ion batteries because it has the ability to exchange more than one Li+ per redox‐active transition‐metal ion. However, this material behavior has been difficult to realize at room temperature due to the redox reaction of Fe3+/Fe4+. In this article, Li2−xFe1−xAlxSiO4/C (x=0, 0.01, 0.03, 0.05, 0.08, 0.12, and 1) nanocomposites were synthesized by using a facile sol–gel method and shown to exhibit much improved electrochemical performance at room temperature. It was found that after doping, two charge–discharge potential plateaus could be clearly obtained. In particular, the examined system, Li1.97Fe0.97Al0.03SiO4/C showed the best electrochemical performance with 209.3 mAh g−1 at 0.2 C, corresponding to a release of 1.26 Li+ per molecule.
Cross‐Case Analysis and Implications for Research, Theory, and Practice
Authors: Cousins J. Bradley , Bourgeois Isabelle 
Published: March 2014

AbstractChapter 2 of this volume provided a close look at the evaluation capacity of eight distinct organizations. The organizations were selected on the basis of their interest in and commitment to evaluation as leverage for program and organizational change. Having examined each of the organizations in terms of context, evaluation drivers, evaluation capacity to do and use evaluation, and forces and factors that affect such capacity, this chapter looks across them in order to learn more about the complexities of evaluation capacity. Beginning with a cross‐case lens, we recapitulate what we found from the cases about organizational evaluation capacity and then present an emergent thematic analysis and discussion. The chapter ends with some implications for research, theory, and practice in the area.
U-Shaped Association Between Serum 25-Hydroxyvitamin D and Fracture Risk in Older Men: Results From the Prospective Population-Based CHAMP Study
Authors: Bleicher Kerrin , Cumming Robert G , Naganathan Vasikaran , Blyth Fiona M , Couteur David G Le , Handelsman David J , Waite Louise M , Seibel Markus J 
Published: March 2014

ABSTRACT The aim of this population-based, prospective, observational study was to examine the relationship between serum levels of 25-hydroxyvitamin D (25OHD) and fracture risk in a cohort of 1662 community-dwelling men aged 70 to 97 years followed for a mean of 4.3 years. Data about mobility, muscle strength, balance, medication use, cognition, medical history, lifestyle factors, renal function, and serum 25OHD were collected at baseline. Data on radiologically verified fractures were collected every 4 months. The relationship between fractures and serum 25OHD levels was analyzed using Cox's proportional hazard regression. We accounted for bone mineral density, falls, physical activity, sun exposure, and season of blood draw, in addition to anthropometric and lifestyle factors, medical history, muscle strength, balance, and medication and supplement use. There were 123 first-incident fragility fractures. The relationship between baseline 25OHD and fracture risk was U-shaped, with increased fracture risk in men with either low or high serum 25OHD levels. In multivariate analysis, the risk of fracture was greatest in men with 25OHD levels in the lowest quintile (25OHD ≤36 nmol/L; hazard ratio [HR] = 3.5; 95% confidence interval [CI] 1.7–7.0) and in men in the highest quintile (25OHD &gt;72 nmol/L; HR = 2.7; 95% CI 1.4–5.4) compared with men in the 4th quintile (25OHD ≥60 to ≤72 nmol/L). These associations were not explained by lower BMD, increased physical activity, fall risk, or other lifestyle or anthropomorphic factors. In community-dwelling older men, there appears to be a healthy target range for serum 25OHD concentrations. Thus, serum 25OHD levels too high and too low may be harmful in regard to fracture risk. © 2014 American Society for Bone and Mineral Research.