bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Pleistocene Succession in the Lower parts of the Thames Valley
Authors: King W. B. R. , Oakley K. P. 
Published: February 2015

The object of the present communication is to demonstrate the relationships which, in the light of present knowledge, appear to exist between the various Pleistocene and Holocene deposits in the Lower and Middle Thames Valley. For this purpose two cross-sections of the valley have been drawn indicating the relative positions of the deposits which occur at various localities as though they were all present in two localities, one in the Lower, and one in the Middle Thames.As many of the more important deposits in the Lower Thames are represented to the north and south of the river in the Dartford area, we have drawn the one section as if our ideal locality occurred in that neighbourhood. In this section, therefore, the relative altitudes of the various beds above and below present river level are those which are found in that part of the Thames basin. In tributary valleys, or in other parts of the main valley these altitudes are not of course necessarily maintained. In cases where deposits belonging to a particular stage have not been preserved in the Dartford area, but occur in a neighbouring part of the valley, or in a tributary valley, their position in the composite section has been roughly gauged by a process of extrapolation. Similarly when dealing with the Middle Thames, we have drawn our ideal section as though all the deposits occurred in one section of the valley in the neighbourhood of Iver.
The Excavation of Long Barrow 163a on Thickthorn Down, Dorset
Authors: Drew C. D. , Piggott Stuart 
Published: February 2015

The culture of the Neolithic Age in Britain established itself particularly firmly in the chalk districts which have their centre in, and radiate from, Salisbury Plain, as is shown by the distribution of some of the most characteristic monuments of the culture, the Long Barrows. Here the open or thinly wooded downland offered every advantage for the pasture of flocks and herds and for early experiments in agriculture, while flint, essential for the tools and weapons of the time, was readily obtainable.One extension of the chalk, running south-west from Salisbury, forms the great ridge of the Dorset downs. This ridge falls abruptly on its northern side, but to the south it slopes more gently, and is furrowed by a number of pleasant valleys, which eventually find their way to the sea either at Christchurch or Poole Harbours.At Blandford, the ridge is cleft by the narrow valley of the River Stour, and the whole area between Salisbury and Blandford lies within the ancient bounds of Cranborne Chase.On this part of the ridge, which rises to 911 feet at Win Green, is an important concentration of Long Barrows. They number 32, and all except four of them are on the southern slopes, roughly between the 400 and 200 feet contours. They are frequently, but not always, situated on the summit of the spurs of the main ridge which separate one side valley from another.
Tuberculosis incidence in the Irish Traveller population in Ireland from 2002 to 2013
Authors: O'TOOLE R. F. , JACKSON S. , HANWAY A. , O'DONNELL J. , COMISKEY C. M. , ROGERS T. R. , O'FLANAGAN D. 
Published: February 2015

SUMMARYThe health status of the Irish Traveller ethnic minority is low compared to the general population in Ireland in terms of infant mortality rates and life expectancies. Respiratory disease is an area of health disparity manifested as excess mortalities in Traveller males and females. In this study, we examined the available data with regard to tuberculosis (TB) notifications in Ireland from 2002 to 2013. We found an increase in TB notifications in Irish Travellers from 2010 onwards. This resulted in a crude incidence rate for TB in Irish Travellers that was approximately threefold higher than that of the white Irish-born population in 2011 and 2012. An outbreak of TB in Irish Travellers in 2013 increased this differential further, but when outbreak-linked cases were excluded, a higher incidence rate was still observed in Irish Travellers relative to the general population and to white Irish-born. The mean age of a TB patient was 26 years in Irish Travellers compared to 43 years in the general population, and 49 years in white Irish-born. Based on available data, Irish Travellers exhibit a higher incidence rate and younger age distribution of TB compared to white Irish-born and the general population. These observations emphasize the importance of routine use of ethnicity identifiers in the management of TB and other notifiable communicable illnesses in Ireland. They also have implications for the orientation of preventive services to address health disparities in Irish Travellers and other ethnic minority groups.
XRMA and ToF-SIMS Analysis of Normal and Hypomineralized Enamel
Authors: Melin Lisa , Lundgren Jesper , Malmberg Per , Norén Jörgen G. , Taube Fabian , Cornell David H. 
Published: February 2015

AbstractMolar incisor hypomineralization (MIH) is a developmental disturbance of the enamel. This study presents analyses of hypomineralized and normal enamel in first molar teeth diagnosed with MIH, utilizing time-of-flight secondary ion mass spectrometry area analyses and X-ray microanalysis of area and spot profiles in uncoated samples between gold lines which provide electrical conductivity. Statistical analysis of mean values allows discrimination of normal from MIH enamel, which has higher Mg and lower Na and P. Inductive analysis using complete data sets for profiles from the enamel surface to the enamel–dentin junction found that Mg, Cl and position in the profile provide useful discrimination criteria. Element profiles provide a visual complement to the inductive analysis and several elements also provide insight into the development of both normal and MIH enamel. The higher Mg content and different Cl profiles of hypomineralized enamel compared with normal enamel are probably related to a relatively short period during the development of ameloblasts between birth and the 1st year of life.
REMARKS ON NAIVE SET THEORY BASED ONLP
Authors: OMORI HITOSHI 
Published: February 2015

AbstractDialetheism is the metaphysical claim that there are true contradictions. And based on this view, Graham Priest and his collaborators have been suggesting solutions to a number of paradoxes. Those paradoxes include Russell’s paradox in naive set theory. For the purpose of dealing with this paradox, Priest is known to have argued against the presence of classical negation in the underlying logic of naive set theory. The aim of the present paper is to challenge this view by showing that there is a way to handle classical negation.
Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion
Authors: Morlé A , Garrido C , Micheau O 
Published: February 2015

AbstractTRAIL is involved in immune tumor surveillance and is considered a promising anti-cancer agent owing to its limited side effects on healthy cells. However, some cancer cells display resistance, or become resistant to TRAIL-induced cell death. Hyperthermia can enhance sensitivity to TRAIL-induced cell death in various resistant cancer cell lines, including lung, breast, colon or prostate carcinomas. Mild heat shock treatment has been proposed to restore Fas ligand or TRAIL-induced apoptosis through c-FLIP degradation or the mitochondrial pathway. We demonstrate here that neither the mitochondria nor c-FLIP degradation are required for TRAIL-induced cell death restoration during hyperthermia. Our data provide evidence that insolubilization of c-FLIP, alone, is sufficient to enhance apoptosis induced by death receptors. Hyperthermia induced c-FLIP depletion from the cytosolic fraction, without apparent degradation, thereby preventing c-FLIP recruitment to the TRAIL DISC and allowing efficient caspase-8 cleavage and apoptosis. Hyperthermia-induced c-FLIP depletion was independent of c-FLIP DED2 FL chain assembly motif or ubiquitination-mediated c-FLIP degradation, as assessed using c-FLIP point mutants on lysine 167 and 195 or threonine 166, a phosphorylation site known to regulate ubiquitination of c-FLIP. Rather, c-FLIP depletion was associated with aggregation, because addition of glycerol not only prevented the loss of c-FLIP from the cytosol but also enabled c-FLIP recruitment within the TRAIL DISC, thus inhibiting TRAIL-induced apoptosis during hyperthermia. Altogether our results demonstrate that c-FLIP is a thermosensitive protein whose targeting by hyperthermia allows restoration of apoptosis induced by TNF ligands, including TRAIL. Our findings suggest that combining TRAIL agonists with whole-body or localized hyperthermia may be an interesting approach in cancer therapy.
A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity
Authors: Kramer D , Schön M , Bayerlová M , Bleckmann A , Schön M P , Zörnig M , Dobbelstein M 
Published: February 2015

AbstractThe p53 family and its cofactors are potent inducers of apoptosis and form a barrier to cancer. Here, we investigated the impact of the supposedly inhibitory member of the apoptosis-stimulating protein of p53, iASPP, on the activity of the p53 homolog TAp73, and its cofactors p300 and CBP. We found that iASPP interacted with and stabilized the histone acetyltransferase p300 and its homolog CBP upon cisplatin treatment. Vice versa, iASPP depletion by shRNA resulted in decreased amounts of p300 and CBP, impaired binding of p300 and TAp73 to target site promoters, reduced induction of pro-apoptotic TAp73 target genes, and impaired apoptosis. Mechanistically, we observed that the p300-regulatory E3 ubiquitin ligase BRMS1 could rescue the degradation of p300 and CBP in cisplatin-treated, iASPP-depleted cells. This argues that iASPP stabilizes p300 and CBP by interfering with their BRMS1-mediated ubiquitination, thereby contributing to apoptotic susceptibility. In line, iASPP overexpression partially abolished the interaction of BRMS1 and CBP upon DNA damage. Reduced levels of iASPP mRNA and protein as well as CBP protein were observed in human melanoma compared with normal skin tissue and benign melanocytic nevi. In line with our findings, iASPP overexpression or knockdown of BRMS1 each augmented p300/CBP levels in melanoma cell lines, thereby enhancing apoptosis upon DNA damage. Taken together, destabilization of p300/CBP by downregulation of iASPP expression levels appears to represent a molecular mechanism that contributes to chemoresistance in melanoma cells.
p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-κB/IL-6 activation in renal cell carcinoma
Authors: Zhu Y , Liu H , Xu L , An H , Liu W , Liu Y , Lin Z , Xu J 
Published: February 2015

AbstractThe p21-activated kinase 1 (PAK1), a serine/threonine kinase that orchestrates cytoskeletal remodeling and cell motility, has been shown to function as downstream node for various oncogenic signaling pathways to promote cell proliferation, regulate apoptosis and accelerate mitotic abnormalities, resulting in tumor formation and invasiveness. Although alterations in PAK1 expression and activity have been detected in various human malignancies, its potential biological and clinical significance in renal cell carcinoma (RCC) remains obscure. In this study, we found increased PAK1 and phosphorylated PAK1 levels in tumor tissues according to TNM stage progression. Elevated phosphorylated PAK1 levels associated with progressive features and indicated unfavorable overall survival (OS) as an independent adverse prognosticator for patients with RCC. Moreover, PAK1 kinase activation with constitutive active PAK1 mutant T423E promoted growth, colony formation, migration, invasion and stem-like phenotype of RCC cells, and vice versa, in PAK1 inhibition by PAK1 kinase inactivation with specific PAK1 shRNA, dead kinase PAK1 mutant K299R or allosteric inhibitor IPA3. Stem-like phenotype due to sunitinib administration via increased PAK1 kinase activation could be ameliorated by PAK1 shRNA, PAK1 mutant K299R and IPA3. Furthermore, nuclear factor-κB (NF-κB)/interleukin-6 (IL-6) activation was found to be responsible for PAK1-mediated stem-like phenotype following sunitinib treatment. Both IL-6 neutralizing antibody and IPA3 administration enhanced tumor growth inhibition effect of sunitinib treatment on RCC cells in vitro and in vivo. Our results unraveled that oncogenic activation of PAK1 defines an important mechanism for maintaining stem-like phenotype and sunitinib resistance through NF-κB/IL-6 activation in RCC, lending PAK1-mediated NF-κB/IL-6 activation considerable appeal as novel pharmacological therapeutic targets against sunitinib resistance.
Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage
Authors: Tong Y , Ying H , Liu R , Li L , Bergholz J , Xiao Z-X 
Published: February 2015

AbstractInactivation of the retinoblastoma protein (Rb) has a key role in tumorigenesis. It is well established that Rb function is largely regulated by a dynamic balance of phosphorylation and dephosphorylation. Although much research has been done to understand the mechanisms and function of RB phosphorylation, the regulation of Rb dephosphorylation is still not well understood. In this study, we demonstrate that Pin1 has an important role in the regulation of Rb function in cell cycle progression and S-phase checkpoint upon DNA damage. We show that the Rb C-pocket directly binds to the Pin1 WW domain in vitro and in vivo, and that the phosphorylation of Rb C-pocket by G1/S Cyclin/Cyclin-dependent kinase complexes is critical for mediating this interaction. We further show that Rb-mediated cell cycle arrest and Rb-induced premature cellular senescence are effectively inhibited by Pin1 expression. In addition, DNA damage induces Rb dephosphorylation in a PP2A-dependent manner, and this process is inhibited by Pin1. Furthermore, the overexpression of Pin1 promotes Rb hyperphosphorylation upon S-phase DNA damage. Importantly, both the Pin1 WW domain and isomerase activity are required for its effect on S-phase checkpoint. Moreover, the overexpression of Pin1 is correlated with Rb hyperphosphorylation in breast cancer biopsies. These results indicate that Pin1 has a critical role in the modulation of Rb function by the regulation of Rb dephosphorylation, which may have an important pathological role in cancer development.
A statistically inferred microRNA network identifies breast cancer target miR-940 as an actin cytoskeleton regulator
Authors: Bhajun Ricky , Guyon Laurent , Pitaval Amandine , Sulpice Eric , Combe Stéphanie , Obeid Patricia , Haguet Vincent , Ghorbel Itebeddine , Lajaunie Christian , Gidrol Xavier 
Published: February 2015

AbstractMiRNAs are key regulators of gene expression. By binding to many genes, they create a complex network of gene co-regulation. Here, using a network-based approach, we identified miRNA hub groups by their close connections and common targets. In one cluster containing three miRNAs, miR-612, miR-661 and miR-940, the annotated functions of the co-regulated genes suggested a role in small GTPase signalling. Although the three members of this cluster targeted the same subset of predicted genes, we showed that their overexpression impacted cell fates differently. miR-661 demonstrated enhanced phosphorylation of myosin II and an increase in cell invasion, indicating a possible oncogenic miRNA. On the contrary, miR-612 and miR-940 inhibit phosphorylation of myosin II and cell invasion. Finally, expression profiling in human breast tissues showed that miR-940 was consistently downregulated in breast cancer tissues
ycf1, the most promising plastid DNA barcode of land plants
Authors: Dong Wenpan , Xu Chao , Li Changhao , Sun Jiahui , Zuo Yunjuan , Shi Shuo , Cheng Tao , Guo Junjie , Zhou Shiliang 
Published: February 2015

AbstractA DNA barcode is a DNA fragment used to identify species. For land plants, DNA fragments of plastid genome could be the primary consideration. Unfortunately, most of the plastid candidate barcodes lack species-level resolution. The identification of DNA barcodes of high resolution at species level is critical to the success of DNA barcoding in plants. We searched the available plastid genomes for the most variable regions and tested the best candidates using both a large number of tree species and seven well-sampled plant groups. Two regions of the plastid gene ycf1, ycf1a and ycf1b, were the most variable loci that were better than existing plastid candidate barcodes and can serve as a barcode of land plants. Primers were designed for the amplification of these regions and the PCR success of these primers ranged from 82.80% to 98.17%. Of 420 tree species, 357 species could be distinguished using ycf1b, which was slightly better than the combination of matK and rbcL. For the well-sampled representative plant groups, ycf1b generally performed better than any of the matK, rbcL and trnH-psbA. We concluded that ycf1a or ycf1b is the most variable plastid genome region and can serve as a core barcode of land plants.
Clocking the anisotropic lattice dynamics of multi-walled carbon nanotubes by four-dimensional ultrafast transmission electron microscopy
Authors: Cao Gaolong , Sun Shuaishuai , Li Zhongwen , Tian Huanfang , Yang Huaixin , Li Jianqi 
Published: February 2015

AbstractRecent advances in the four-dimensional ultrafast transmission electron microscope (4D-UTEM) with combined spatial and temporal resolutions have made it possible to directly visualize structural dynamics of materials at the atomic level. Herein, we report on our development on a 4D-UTEM which can be operated properly on either the photo-emission or the thermionic mode. We demonstrate its ability to obtain sequences of snapshots with high spatial and temporal resolutions in the study of lattice dynamics of the multi-walled carbon nanotubes (MWCNTs). This investigation provides an atomic level description of remarkable anisotropic lattice dynamics at the picosecond timescales. Moreover, our UTEM measurements clearly reveal that distinguishable lattice relaxations appear in intra-tubular sheets on an ultrafast timescale of a few picoseconds and after then an evident lattice expansion along the radial direction. These anisotropic behaviors in the MWCNTs are considered arising from the variety of chemical bonding, i.e. the weak van der Waals bonding between the tubular planes and the strong covalent sp2-hybridized bonds in the tubular sheets.
Pangea breakup and northward drift of the Indian subcontinent reproduced by a numerical model of mantle convection
Authors: Yoshida Masaki , Hamano Yozo 
Published: February 2015

AbstractSince around 200 Ma, the most notable event in the process of the breakup of Pangea has been the high speed (up to 20 cm yr−1) of the northward drift of the Indian subcontinent. Our numerical simulations of 3-D spherical mantle convection approximately reproduced the process of continental drift from the breakup of Pangea at 200 Ma to the present-day continental distribution. These simulations revealed that a major factor in the northward drift of the Indian subcontinent was the large-scale cold mantle downwelling that developed spontaneously in the North Tethys Ocean, attributed to the overall shape of Pangea. The strong lateral mantle flow caused by the high-temperature anomaly beneath Pangea, due to the thermal insulation effect, enhanced the acceleration of the Indian subcontinent during the early stage of the Pangea breakup. The large-scale hot upwelling plumes from the lower mantle, initially located under Africa, might have contributed to the formation of the large-scale cold mantle downwelling in the North Tethys Ocean.
Future projection of radiocesium flux to the ocean from the largest river impacted by Fukushima Daiichi Nuclear Power Plant
Authors: Adhiraga Pratama Mochamad , Yoneda Minoru , Shimada Yoko , Matsui Yasuto , Yamashiki Yosuke 
Published: February 2015

AbstractFollowing the initial fall out from Fukushima Dai-ichi Nuclear Power Plant (FDNPP), a significant amount of radiocesium has been discharged from Abukuma River into the Pacific Ocean. This study attempted to numerically simulate the flux of radiocesium into Abukuma River by developing the multiple compartment model which incorporate the transport process of the radionuclide from the ground surface of the catchment area into the river, a process called wash off. The results from the model show that the sub-basins with a high percentage of forest area release the radionuclides at lower rate compared to the other sub-basins. In addition the results show that the model could predict the seasonal pattern of the observed data. Despite the overestimation observed between the modeled data and the observed data, the values of R2 obtained from 137Cs and 134Cs of 0.98 and 0.97 respectively demonstrate the accuracy of the model. Prediction of the discharge from the basin area for 100 years after the accident shows that, the flux of radiocesium into the Pacific Ocean is still relatively high with an order of magnitude of 109 bq.month−1 while the total accumulation of the discharge is 111 TBq for 137Cs and 44 TBq for 134Cs.
SIRT2 is involved in the modulation of depressive behaviors
Authors: Liu Rui , Dang Wei , Du Ying , Zhou Qiong , Jiao Kai , Liu Zhaohui 
Published: February 2015

AbstractExposure to chronic stress produces negative effects on mood and hippocampus-dependent memory formation. SIRT2 alteration has been reported in mood disorders; however, the role of SIRT2 in depression remains unclear. Therefore, we aimed to determine whether SIRT2 can restore stress-induced suppression of neurogenesis in a rat chronic unpredictable stress (CUS) model of depression. Sucrose preference test, home-cage locomotion, forced swim test and elevated plus maze were used to determine the role of SIRT2 in CUS model. To further determine the hippocampal neurogenesis contributes to the role of SIRT in mediating the antidepressant-like behavior, rats were exposed to X-irradiation to disrupt the process of hippocampal neurogenesis. CUS decreased expression of the SIRT2 protein in the hippocampus. Treatment with the antidepressant fluoxetine reversed the CUS-induced SIRT2 change. Furthermore, inhibiting SIRT2 by tenovin-D3 resulted in depression-like behaviors and impaired hippocampal neurogenesis in rats. Conversely, overexpression of SIRT2 by the intra-hippocampal infusion of recombinant adenovirus vector expressing mouse SIRT2 reversed the CUS-induced depressive-like behaviors and promoted neurogenesis. Disrupting neurogenesis in the dentate gyrus by X-irradiation abolished the antidepressant-like effect of Ad-SIRT2-GFP. These findings indicate that hippocampal SIRT2 is involved in the modulation of depressant-like behaviors, possibly by regulating neurogenesis.