bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leaky Rigid Lid: New Dissipative Modes in the Troposphere
Authors: Chumakova Lyubov G. , Rosales Rodolfo R. , Tabak Esteban G. 
Published: February 2013

Abstract
An effective boundary condition is derived for the top of the troposphere, based on a wave radiation condition at the tropopause. This boundary condition, which can be formulated as a pseudodifferential equation, leads to new vertical dissipative modes. These modes can be computed explicitly in the classical setup of a hydrostatic, nonrotating atmosphere with a piecewise constant Brunt–Väisälä frequency.
In the limit of an infinitely strongly stratified stratosphere, these modes lose their dissipative nature and become the regular baroclinic tropospheric modes under the rigid-lid approximation. For realistic values of the stratification, the decay time scales of the first few modes for mesoscale disturbances range from an hour to a week, suggesting that the time scale for some atmospheric phenomena may be set up by the rate of energy loss through upward-propagating waves.
The Contribution of Radiative Feedbacks to Orbitally Driven Climate Change
Authors: Erb Michael P. , Broccoli Anthony J. , Clement Amy C. 
Published: February 2013

Abstract
Radiative feedbacks influence Earth's climate response to orbital forcing, amplifying some aspects of the response while damping others. To better understand this relationship, the GFDL Climate Model, version 2.1 (CM2.1), is used to perform idealized simulations in which only orbital parameters are altered while ice sheets, atmospheric composition, and other climate forcings are prescribed at preindustrial levels. These idealized simulations isolate the climate response and radiative feedbacks to changes in obliquity and longitude of the perihelion alone. Analysis shows that, despite being forced only by a redistribution of insolation with no global annual-mean component, feedbacks induce significant global-mean climate change, resulting in mean temperature changes of −0.5 K in a lowered obliquity experiment and +0.6 K in a NH winter solstice perihelion minus NH summer solstice perihelion experiment. In the obliquity experiment, some global-mean temperature response may be attributable to vertical variations in the transport of moist static energy anomalies, which can affect radiative feedbacks in remote regions by altering atmospheric stability. In the precession experiment, cloud feedbacks alter the Arctic radiation balance with possible implications for glaciation. At times when the orbital configuration favors glaciation, reductions in cloud water content and low-cloud fraction partially counteract changes in summer insolation, posing an additional challenge to understanding glacial inception. Additionally, several systems, such as the Hadley circulation and monsoons, influence climate feedbacks in ways that would not be anticipated from analysis of feedbacks in the more familiar case of anthropogenic forcing, emphasizing the complexity of feedback responses.
Long-Term Climate Change Commitment and Reversibility: An EMIC Intercomparison
Authors: Zickfeld Kirsten , Eby Michael , Weaver Andrew J. , Alexander Kaitlin , Crespin Elisabeth , Edwards Neil R. , Eliseev Alexey V. , Feulner Georg , Fichefet Thierry , Forest Chris E. , Friedlingstein Pierre , Goosse Hugues , Holden Philip B. , Joos Fortunat , Kawamiya Michio , Kicklighter David , Kienert Hendrik , Matsumoto Katsumi , Mokhov Igor I. , Monier Erwan , Olsen Steffen M. , Pedersen Jens O. P. , Perrette Mahe , Philippon-Berthier Gwenaëlle , Ridgwell Andy , Schlosser Adam , Schneider Von Deimling Thomas , Shaffer Gary , Sokolov Andrei , Spahni Renato , Steinacher Marco , Tachiiri Kaoru , Tokos Kathy S. , Yoshimori Masakazu , Zeng Ning , Zhao Fang 
Published: February 2013

AbstractThis paper summarizes the results of an intercomparison project with Earth System Models of Intermediate Complexity (EMICs) undertaken in support of the Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report (AR5). The focus is on long-term climate projections designed to 1) quantify the climate change commitment of different radiative forcing trajectories and 2) explore the extent to which climate change is reversible on human time scales. All commitment simulations follow the four representative concentration pathways (RCPs) and their extensions to year 2300. Most EMICs simulate substantial surface air temperature and thermosteric sea level rise commitment following stabilization of the atmospheric composition at year-2300 levels. The meridional overturning circulation (MOC) is weakened temporarily and recovers to near-preindustrial values in most models for RCPs 2.6–6.0. The MOC weakening is more persistent for RCP8.5. Elimination of anthropogenic CO2 emissions after 2300 results in slowly decreasing atmospheric CO2 concentrations. At year 3000 atmospheric CO2 is still at more than half its year-2300 level in all EMICs for RCPs 4.5–8.5. Surface air temperature remains constant or decreases slightly and thermosteric sea level rise continues for centuries after elimination of CO2 emissions in all EMICs. Restoration of atmospheric CO2 from RCP to preindustrial levels over 100–1000 years requires large artificial removal of CO2 from the atmosphere and does not result in the simultaneous return to preindustrial climate conditions, as surface air temperature and sea level response exhibit a substantial time lag relative to atmospheric CO2.
Beam Geometry Calibration of Sodars without Use of a Mast
Authors: Bradley Stuart , von Hünerbein Sabine 
Published: February 2013

Abstract
A new method for calibration of sodar wind speed measurements is described. The method makes no assumptions whatsoever about the sodar operation and its hardware and software, other than the assumption that only one beam is transmitted at a time. Regardless of the complexity of the actual beam shape, the effective beam zenith angle is accurately estimated: this is the angle that must be used in estimations of velocity components. In a very simple experiment, the effective beam zenith angle has been found to within around 0.2°, which is as good as is required in the most stringent sodar calibration procedures. It has been found, even for such a short data run, that the estimated beam angle is very close to that calculated from the sodar array geometry. The main limitation is the requirement for horizontally homogeneous flow, since the regression methods use both a tilted beam and a vertical beam. Note that this is also a fundamental limiting assumption in the normal operation of ground-based wind lidars and sodars.
Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease: a prospective controlled study
Authors: Ho Shu-Chuan , Lin Horng-Chyuan , Kuo Han-Pin , Chen Li-Fei , Sheng Te-Fang , Jao Wen-Ching , Wang Chun-Hua , Lee Kang-Yun 
Published: February 2013

Abstract

Background
Exercise training is of benefit for patients with restrictive lung disease. However, it tends to be intolerable for those with severe disease. We examined whether providing ventilatory assistance by using negative pressure ventilators (NPV) during exercise training is feasible for such patients and the effects of training.

Methods
36 patients with restrictive lung disease were prospectively enrolled for a 12-week multidisciplinary rehabilitation program. During this program, half of them (n:18; 60.3 ± 11.6 years; 6 men; FVC: 32.5 ± 11.7% predicted ) received regular sessions of exercise training under NPV, whilst the 18 others (59.6 ± 12.3 years; 8 men; FVC: 37.7 ± 10.2% predicted) did not. Exercise capacity, pulmonary function, dyspnea and quality of life were measured. The primary endpoint was the between-group difference in change of 6 minute-walk distance (6MWD) after 12 weeks of rehabilitation.

Results
All patients in the NPV-exercise group were able to tolerate and completed the program. The between-group differences were significantly better in the NPV-exercise group in changes of 6MWD (34.1 ± 12.7 m vs. -32.5 ± 17.5 m; P = 0.011) and St George Score (−14.5 ± 3.6 vs. 11.8 ± 6.0; P < 0.01). There was an improvement in dyspnea sensation (Borg’s scale, from 1.4 ± 1.5 point to 0.8 ± 1.3 point, P = 0.049) and a small increase in FVC (from 0.85 ± 0.09 L to 0.91 ± 0.08 L, P = 0.029) in the NPV-exercise group compared to the control group.

Conclusion
Exercise training with NPV support is feasible for patients with severe restrictive lung diseases, and improves exercise capacity and health-related quality of life.
Trans-subclavian approach for radiofrequency ablation of premature ventricular contractions originating from subtricuspid annulus: a case report
Authors: Li Teng , Zhan Xian-zhang , Yang Ping-zhen , Xue Yu-mei , Fang Xian-hong , Liao Hong-tao , Wu Shu-lin 
Published: February 2013

Abstract

Background
Catheter ablation has been established as a curative treatment strategy for ventricular arrhythmias. The standard procedure of most ventricular arrhythmias originating from the right ventricle is performed via the femoral vein. However, a femoral vein access may not achieve a successful ablation in some patients.

Case presentation
We reported a case of a 29-year old patient with symptomatic premature ventricular contractions was referred for catheter ablation. Radiofrequency energy application at the earliest endocardial ventricular activation site via the right femoral vein could not eliminate the premature ventricular contractions. Epicardial mapping could not obtain an earlier ventricular activation when compared to the endocardial mapping, and at the earliest epicardial site could not provide an identical pace mapping. Finally, we redeployed the ablation catheter via the right subclavian vein by a long sheath. During mapping of the subvalvular area of the right ventricle, a site with a good pace mapping and early ventricular activation was found, and premature ventricular contractions were eliminated successfully.

Conclusion
Ventricular arrhythmias originating from the subtricuspid annulus may be successfully abolished via a trans-subclavian approach and a long sheath. Although access via the right subclavian vein for mapping and ablation is an effective alternative, it is not a routine approach.
Prevalence of intestinal parasitic infections among highland and lowland dwellers in Gamo area, South Ethiopia
Authors: Wegayehu Teklu , Tsalla Tsegaye , Seifu Belete , Teklu Takele 
Published: February 2013

Abstract

Background
Epidemiological information on the prevalence of intestinal parasitic infections in different regions is a prerequisite to develop appropriate control strategies. Therefore, this present study was conducted to assess the magnitude and pattern of intestinal parasitism in highland and lowland dwellers in Gamo area, South Ethiopia.

Methods
Community-based cross-sectional study was conducted between September 2010 and July 2011 at Lante, Kolla Shelle, Dorze and Geressie kebeles of Gamo Gofa Zone, South Ethiopia. The study sites and study participants were selected using multistage sampling method. Data were gathered through house-to-house survey. A total of 858 stool specimens were collected and processed using direct wet mount and formol-ether concentration techniques for the presence of parasite.

Results
Out of the total examined subjects, 342(39.9%) were found positive for at least one intestinal parasite. The prevalence of Entamoeba histolytica/dispar was the highest 98(11.4%), followed by Giardia lamblia 91(10.6%), Ascaris lumbricoides 67(7.8%), Strongyloides stercoralis 51(5.9%), hookworm 42(4.9%), Trichuris trichiura 24(2.8%), Taenia species 18(2.1%), Hymenolepis nana 7(0.6%) and Schistosoma mansoni 1(0.12%). No statistically significant difference was observed in the prevalence of intestinal parasitic infections among lowland (37.9%) and highland dwellers (42.3%) (P = 0.185). The prevalence of intestinal parasitic infection was not significantly different among the study sites but it was relatively higher in Geressie (42.8%) than other kebeles. Sex was not associated with parasitic infections (P = 0.481). No statistically significant difference of infection was observed among the age groups (P = 0.228) but it was higher in reproductive age group.

Conclusions
The high prevalence of intestinal parasitic infections among the lowland and highland dwellers in Gamo area indicated that parasitic infections are important public health problems. Thus, infection control measures and the development of awareness strategies to improve sanitation and health education should be considered.
Views of general practitioners on the role of CA125 in primary care to diagnose ovarian cancer
Authors: Moss Esther L , Moran Alison , Reynolds Timothy M , Stokes-Lampard Helen 
Published: February 2013

Abstract

Background
NICE guidance on the investigation and treatment of ovarian cancer advocates that the tumour marker CA125 should be the first line investigation for women suspected of having ovarian cancer.

Methods
An internet-based survey, of primary care doctors in the West Midlands, was conducted in order to ascertain the views of general practitioners (GPs) of NICE guidance on the use of CA125 to triage suspected ovarian cancer cancers and the impact that this may have on referral pathways.

Results
In total 258 GPs responded to the questionnaire. Although 219 (84.9%) responders reported awareness of the NICE guidance only 146 (56.6%) had personally read the document. The majority 187 (72.5%) of respondents anticipated that their use of CA125 would increase as a result of the new guidance. Abdominal bloating (>50 years), persistent abdominal distension and the presence of an abdominal or pelvic mass/swelling were the symptoms felt to be most associated with ovarian cancer. When questioned on the management of a woman with a raised CA125 the majority of respondents reported that a normal ultrasound scan would not stop an urgent secondary care referral if the CA125 was raised. There was no significant difference in the opinions of GPs with <5 years primary care experience compared to GPs with 6+ years.

Conclusion
The symptoms associated with ovarian cancer are well understood by the GPs that responded however, a coordinated programme of education and training is needed for GPs on the role of CA125 in ovarian cancer, in addition to clearly defined referral pathways, in order to address a likely significant increase in suspected ovarian cancer referrals to secondary care, most of whom will not have ovarian cancer.
Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration
Authors: Ono Yoshikazu , Kurano Makoto , Ohkawa Ryunosuke , Yokota Hiromitsu , Igarashi Koji , Aoki Junken , Tozuka Minoru , Yatomi Yutaka 
Published: February 2013

Abstract

Background
Sphingosine 1-phosphate (Sph-1-P), abundantly stored in platelets and released extracellularly upon activation, plays important roles as an extracellular mediator by interacting with specific cell surface receptors, especially in the area of vascular biology and immunology/hematology. Although the plasma Sph-1-P level is reportedly determined by red blood cells (RBCs), but not platelets, this may not be true in cases where the platelets have been substantially activated.

Methods and results
We measured the Sph-1-P and dihydrosphingosine 1-phosphate (DHSph-1-P) levels in serum samples (in which the platelets had been fully activated) from subjects with (n = 21) and without (n = 33) hematological disorders. We found that patients with essential thrombocythemia exhibited higher serum Sph-1-P and DHSph-1-P concentrations. The serum Sph-1-P concentration was closely correlated with the platelet count but was very weakly correlated with the RBC count. Similar results were obtained for DHSph-1-P. The serum Sph-1-P and DHSph-1-P levels were inversely correlated with the level of autotaxin (ATX), a lysophosphatidic acid-producing enzyme. A multiple regression analysis also revealed that the platelet count had the greatest explanatory impact on the serum Sph-1-P level.

Conclusions
Our present results showed close correlations between both the serum Sph-1-P and DHSph-1-P levels and the platelet count (but not the RBC count); these results suggest that high concentrations of these sphingoid base phosphates may be released from platelets and may mediate cross talk between platelet activation and the formation of atherosclerotic lesions.
Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction – a randomised placebo-controlled trial (KARE): study protocol
Authors: Cross Laurence JM , O’Kane Cecilia M , McDowell Cliona , Elborn Jospeh J , Matthay Michael A , McAuley Daniel F 
Published: February 2013

Abstract

Background
Acute lung injury is a common, devastating clinical syndrome associated with substantial mortality and morbidity with currently no proven therapeutic interventional strategy to improve patient outcomes. The objectives of this study are to test the potential therapeutic effects of keratinocyte growth factor for patients with acute lung injury on oxygenation and biological indicators of acute inflammation, lung epithelial and endothelial function, protease:antiprotease balance, and lung extracellular matrix degradation and turnover.

Methods/design
This will be a prospective, randomised, double-blind, allocation-concealed, placebo-controlled, phase 2, multicentre trial. Randomisation will be stratified by presence of severe sepsis requiring vasopressors. Patients in an ICU fulfilling the American–European Consensus Conference Definition of acute lung injury will be randomised in a 1:1 ratio to receive an intravenous bolus of either keratinocyte growth factor (palifermin, 60 μg/kg) or placebo (0.9% sodium chloride solution) daily for a maximum of 6 days. The primary endpoint of this clinical study is to evaluate the efficacy of palifermin to improve the oxygenation index at day 7 or the last available oxygenation index prior to patient discontinuation from the study.
A formal statistical analysis plan has been constructed. Analyses will be carried out on an intention-to-treat basis. A single analysis is planned at the end of the trial. P = 0.05 will be considered statistically significant and all tests will be two-sided. For continuously distributed outcomes, differences between groups will be tested using independent-sample t tests, analysis of variance and analysis of covariance with transformation of variables to normality or nonparametric equivalents. The trial will be reported in line with the Consolidated Standards of Reporting Trials (Consort 2010 guidelines).

Trial registration

http://ISRCTN95690673
Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies
Authors: Xiong Yan , Bai Yun , Leong Nufatt , Laughlin Todd S , Rothberg Paul G , Xu Haodong , Nong Lin , Zhao Jing , Dong Ying , Li Ting 
Published: February 2013

Abstract

Background
The recent development of antibodies specific for the major hotspot mutations in the epidermal growth factor receptor (EGFR), L858R and E746_A750del, may provide an opportunity to use immunohistochemistry (IHC) as a screening test for EGFR gene mutations. This study was designed to optimize the IHC protocol and the criteria for interpretation of the results using DNA sequencing as the gold-standard.

Methods
Tumor sections from fifty lung adenocarcinoma specimens from Chinese patients were immunostained using L858R and E746_A750del-specific antibodies using three different antigen retrieval solutions, and the results were evaluated using three different sets of criteria. The same specimens were used for DNA purification and analysis of EGFR gene mutations.

Results
In this study the optimal buffer for antigen retrieval was EDTA (pH 8.0), and the optimal scoring method was to call positive results when there was moderate to strong staining of membrane and/or cytoplasm in >10% of the tumor cells. Using the optimized protocol, L858R-specific IHC showed a sensitivity of 81% and a specificity of 97%, and E746_A750del-specific IHC showed a sensitivity of 59% and a specificity of 100%, both compared with direct DNA analysis. Additionally, the mutant proteins as assessed by IHC showed a more homogeneous than heterogeneous pattern of expression.

Conclusions
Our data demonstrate that mutation-specific IHC, using optimized procedures, is a reliable prescreening test for detecting EGFR mutations in lung adenocarcinoma.

Virtual Slides
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2059012601872392
CD44/CD24 immunophenotypes on clinicopathologic features of salivary glands malignant neoplasms
Authors: Soave Danilo Figueiredo , Oliveira da Costa João Paulo , da Silveira Giorgia Gobbi , Ianez Renata Carolina Fraga , de Oliveira Lucinei Roberto , Lourenço Silvia Vanessa , Ribeiro-Silva Alfredo 
Published: February 2013

AbstractBackgroundSalivary Glands Malignant Neoplasms (SGMNs) account for 3-6% of head and neck cancers and 0.3% of all cancers. Tumor cells that express CD44 and CD24 exhibit a stem-cell-like behavior. CD44 is the binding site for hyaluronic acid, and CD24 is a receptor that interacts with P-selectin to induce metastasis and tumor progression. The present study aims to evaluate the expression of CD44 and CD24 on SGMNs and correlated these data with several clinicopathologic features.MethodsImmunohistochemical stains for CD44 and CD24 were performed on tissue microarrays containing SGMN samples from 69 patients. The CD44, CD24 and CD44/CD24 expression phenotypes were correlated to patient clinicopathologic features and outcome.ResultsCD44 expression was associated with the primary site of neoplasm (p = 0.046). CD24 was associated with clinical stage III/IV (p = 0.008), T stage (p = 0,27) and lymph node (p = 0,001). The CD44/CD24 profiles were associated with the primary site of injury (p = 0.005), lymph node (p = 0.011) and T stage (p = 0.023). Univariate analysis showed a significant relationship between clinical staging and disease- free survival (p = 0.009), and the overall survival presents relation with male gender (p = 0.011) and metastasis (p = 0.027).ConclusionIn summary, our investigation confirms that the clinical stage, in accordance with the literature, is the main prognostic factor for SGMN. Additionally, we have presented some evidence that the analysis of isolated CD44 and CD24 immunoexpression or the two combined markers could give prognostic information associated to clinicopathologic features in SGMN.Virtual SlidesThe virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1284611098470676.