bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eupatorium Lindleyanum DC. Extract Protects against MPTP-induced Mouse of Parkinson’s Disease by Targeting Neuroinflammation
Authors: Zhang Yichi , Yao Lu , Zhang Xiaowen , Yang Zhuo , Chen Yang , Zheng Lingli , Zheng Yongzhe , Yu Wei , Mamadalieva Nilufar Z. , Han Bo , Tu Pengfei , Mukhamatkhanova Rimma F. , Zeng Kewu 
Published: June 2024

Article
Eupatorium Lindleyanum DC. Extract Protects against MPTP-induced Mouse of Parkinson’s Disease by Targeting Neuroinflammation

Yichi Zhang 1, Lu Yao 1, Xiaowen Zhang 1, Zhuo Yang 1, Yang Chen 2, Lingli Zheng 1, Yongzhe Zheng 1, Wei Yu 2, Nilufar Z. Mamadalieva 3, Bo Han 2, Pengfei Tu 1, Rimma F. Mukhamatkhanova 3, and Kewu Zeng 1, *

1 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
2 School of Pharmacy/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Shihezi University, Shihezi 832003, China
3 Institute of the Chemistry of Plant Substances AS RUz, Mirzo Ulugbek Str 77, Tashkent 100170, Uzbekistan
* Correspondence: ZKW@bjmu.edu.cn

Received: 10 May 2024; Revised: 14 May 2024; Accepted: 24 May 2024; Published: 6 June 2024

Abstract: Background: Neuroinflammation plays a vital role in the pathology of Parkinson’s disease (PD). Eupatorium lindleyanum DC. (EL) has previously reported to exert anti-inflammation activity. Methods: In the present study, we examined the effects of the EL extract (ELE) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD and potential molecular mechanisms. The anti-neuroinflammation effect of ELE was also determined in lipopolysaccharide (LPS)-induced BV-2 cells in vitro. Moreover, the ELE-interacting target proteins were identified. And the bioinformatics analysis was performed based on the identified targets. Results: Our results showed that ELE significantly alleviated motor performance impairment and neuronal damage in MPTP-induced PD mice. In particular, ELE reversed MPTP-induced neuroinflammation via inhibiting microglial activation that was associated with progressive PD. Moreover, the anti-neuroinflammation effect of ELE was confirmed in LPS-induced BV-2 cells by detecting the release of pro-inflammatory factors such as nitric oxide (NO), interleukin-6 (Il-6), tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, the ELE- interacting target proteins were identified by affinity purification-mass spectrometry-based proteomics strategy. Then, AMP-activated protein kinase (AMPK) signaling pathway was enriched by kyoto encyclopedia of genes and genomes (KEGG) analysis. We found that ELE markedly increased AMPK phosphorylation and inhibited nuclear factor-κB (NF-κB) signal in BV-2 cells. Conclusion: Collectively, these results indicate that ELE may exert significant neuroprotective effects against PD via targeting neuroinflammation.
The Role of the CREB Signaling Pathway in Tumor Development and Therapeutic Potential
Authors: Jin Qunlong , Jiang Youheng , Zhang Zhiheng , Yang Yanming , Fu Zhang , Gao Yunfeng , Li Ningning , He Yulong , Li Changxue 
Published: June 2024

Review
The Role of the CREB Signaling Pathway in Tumor Development and Therapeutic Potential

Qunlong Jin 1,2,†, Youheng Jiang 1,2,†, Zhiheng Zhang 1,3,†, Yanming Yang 1, Zhang Fu 1, Yunfeng Gao 1,4, Ningning Li 1,5, Yulong He 2,*, and Changxue Li 1,2,*

1 Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, China
2 Digestive Diseases Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, China
3 The Affiliated High School of Shenzhen University, Shenzhen, 518066, China
4 Department of Otolaryngology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, China
5 China-UK Institute for Frontier Science, Shenzhen, 518107, China
† These authors contributed equally to this work.
* Correspondence: heyulong@mail.sysu.edu.cn (Y.L.H.); lichx59@mail2.sysu.edu.cn (C.X.L.)

Received: 2 May 2024; Revised: 19 May 2024; Accepted: 20 May 2024; Published: 11 June 2024

Abstract: The cAMP response element-binding protein (CREB) is a multifunctional transcription factor belonging to the basic leucine zipper (bZIP) family of proteins. It regulates the expression of target genes by binding to the cAMP response element (CRE) on DNA. The activation of CREB in cells typically depends on its phosphorylation, mediated by kinases activated by various signaling pathways, such as the cAMP-dependent protein kinase A (PKA) pathway and the PI3K-AKT pathway. CREB regulates genes involved in various cellular functions, including cell growth, differentiation, survival, as well as the development and plasticity of the nervous system. Therefore, CREB plays a key role in the development of neurological diseases, oncology, and other diseases. This review aims to systematically elucidate the structure and regulatory mechanisms of CREB, its biological function in tumors, and the potential of targeting the CREB signaling pathway in anti-tumor therapy, with the hope of providing new strategies and targets for cancer treatment.
Distillation-Based User Selection for Heterogeneous Feder-ated Learning
Authors: Li Bowen , Li Wenling 
Published: June 2024

Article
Distillation-Based User Selection for Heterogeneous Federated Learning

Bowen Li, and Wenling Li *

School of Automation Science and Electrical Engineering, Beihang University, Beijing 100191, China
* Correspondence: lwlmath@buaa.edu.cn

Received: 7 September 2023
Accepted: 9 November 2023
Published: 26 June 2024

Abstract: Federated learning is a newly developing distributed machine learning technology, which makes it possible for users to train machine learning models with decentralized privacy data. Owing to huge communication overhead, the traditional federated learning algorithm samples user data randomly, which may reduce the performance of the model due to the statistical heterogeneity of users. In this paper, we propose a distillation-based user selection algorithm for federated learning in heterogeneous situations. Based on knowledge distillation, the soft targets of users are uploaded to the server as a basis for user selection. Our algorithm reduces the statistical heterogeneity of selected users, resulting in low additional communication and computation overhead. Experiments implemented on MNIST and fashion-MNIST show that the proposed algorithm obtains better model performance as compared to the federated averaging algorithm and several other user selection algorithms.
СПОСОБЫ СОПОСТАВЛЕНИЯ МЕТОДОВ ПО ПРИМЕНЕНИЮ СОДЕРЖАНИЯ МАТЕРИАЛОВ БУДУЩИХ УЧИТЕЛЕЙ ИНФОРМАТИКИ
Authors: Жакиева С. 
Published: June 2024

Предметом исследования в данной работе являются методы комбинирования методов обучения применительно к содержанию учебного материала будущего учителя информатики. Цель исследования: определить способы комбинирования методов обучения учителя информатики относительно содержания учебного материала. Методы исследования – использовались методы анализа и обобщения. Выделены четыре типа интеграции, подкрепленные примерами из уроков информатики. Первый вид учебного материала объясняется преподавателем целиком, второй – это только основной материал по теме, третий – дифференцирование и объяснение нового материала, четвертый – самостоятельная работа учащихся. Комбинацию методов он рассмотрел на примере тем некоторых занятий программы. Умение будущих учителей совмещать методы обучения по их содержанию с самостоятельной работой учащихся считается первостепенным для будущей профессии преподавателя информатики и учителя в целом.
Verstoringen rondom de algemene vergadering van een beursvennootschap
Authors: Rensen G.J.C. , Leemrijse J.J.C.A. , van Rooijen K.M. 
Published: June 2024

Verstoringen rondom de algemene vergadering van een beursvennootschap
De afgelopen jaren worden beursvennootschappen tijdens hun algemene vergaderingen regelmatig geconfronteerd met optreden van aandeelhouders dat verstorend kan zijn voor een ordelijk verloop van de vergadering. Deze bijdrage gaat in op de wijzen waarop daarmee in (fysieke, hybride en digitale) algemene vergaderingen kan worden omgegaan.
Working conditions and common mental disorders in nurses facing Covid-19
Authors: Guimarães José Maria Ximenes , Amorim Ednaiane Priscila de Andrade , Garcia Filho Carlos , Pequeno Alice Maria Correia , Pinto Diana Muniz , Mendonça Aglay Galvão Francelino , Silva Francisca Liliane Torres da , Vieira-Meyer Anya Pimentel Gomes Ferreira 
Published: June 2024

Introduction: The Coronavirus disease pandemic represents the biggest public health emergency faced globally in decades, with repercussions on the mental health of nursing professionals. Aims: This study analyzed working conditions and their impact on the mental health of nurses facing COVID-19. Methods: A total of 192 nurses answered an electronic questionnaire. Screening for Common Mental Disorders (CMD) was performed using the Self-Reporting Questionnaire (SRQ-20), and associations between the dependent and independent variables were tested. Results: The prevalence of suspected CMD was 53.1%, and this outcome was associated with female gender (p<0.005), insufficient personal protective equipment in quantity and quality (p<0.006), insufficient biosafety standards (p<0.045), being at risk of transmitting COVID-19 (p<0.001), and having a family member with COVID-19 symptoms (p<0.029). Discussion and Conclusions: The study demonstrates the negative impact of the COVID-19 pandemic on nurses' mental health and reinforces the need for psychological support for health workers.
Diagnóstico de las actividades de control en la Municipalidad Distrital de Choropampa 2022
Authors: Cabrera Taipa Elder Jhonatan , Gonzáles Angaspilco Yerly Ceciclia , Castro Vargas Daniel Jesús , Cueva Valdivia Johnny 
Published: June 2024

El control interno es esencial para garantizar la integridad, transparencia y eficiencia de una entidad, protegiendo sus activos y recursos, asegurando el cumplimiento de las normativas y facilitando una gestión eficaz y responsable. El propósito de la investigación fue analizar las actividades de control en la Municipalidad Distrital de Choropampa. Se utilizó la metodología de alcance descriptivo con enfoque cuantitativo, utilizando un diseño no experimental - transversal. La muestra consistió en 8 colaboradores de la entidad a quienes se les aplicó una encuesta. Los resultados revelaron que las actividades de control para la mitigación de riesgos se desarrollan de manera continua, permitiendo la implantación de medidas de corrección. Así mismo, se encontró eficiencia en el control de requerimientos, actividades y presupuesto con respecto a actividades de control para TI, evidenciado que las herramientas tecnológicas implementadas favorecen la fluidez de comunicación entre áreas. En relación con el control de las políticas y procedimientos, se observó un control adecuado en acciones con respecto a los gastos e ingresos, acciones de mejora continua y correcciones de funciones, gestión institucional. En conclusión, las actividades de control en la Municipalidad se encuentran en un nivel regular y bueno con porcentajes de 37.50% y 62.50% respectivamente.
Relationship of endogenous antioxidant levels with metabolic control parameters in diabetic infantile-juvenile patients
Authors: Pérez Álvarez Yohanka , Díaz Calzada Marvelia , Montier Iglesias Ariel , Fuentes de la Rosa Yazuina , Roque Acanda Kenia , Rodríguez Sardiñas Lázara Maidelys 
Published: June 2024

Introduction: diabetes mellitus is one of the pandemics of the present century that severely affects the infantile-juvenile population, due, among other factors, to poor nutritional habits. Objective: to test the changes in the levels of endogenous nucleophilic antioxidants in relation to control parameters in patients with infantile-juvenile diabetes. Material and Method. Of the 138 patients with infantile-juvenile diabetes who attended the provincial consultation at the Specialties Polyclinic of the Provincial Pediatric Hospital ¨Pepe Portilla¨ in the period from March 2019 to June 2020, 28 patients were chosen by means of a purposive sampling. The following variables were collected: age, sex, weight and height for calculation of body mass index, fasting blood glucose, HbA1c, albumin and uric acid. Absolute and relative frequency were used for qualitative variables and mean, standard deviation and median for quantitative variables. When the non-normal distribution of the data was found by the Shapiro-Wilk test, Spearman's correlation coefficient was used with a level of certainty of 95% to evaluate the relationship between the quantitative variables. Results. Glycemia showed no correlation with either serum albumin or uric acid values. A positive and statistically significant correlation was found between HbA1c values with serum albumin and uric acid (p<0.05). Conclusions. In conditions of oxidative stress generated in infantile-juvenile diabetes the levels of endogenous nucleophilic antioxidants are modified directly and proportionally, with changes in the values of glycosylated hemoglobin
Ensuring equity against odds- COVID-19 Vaccination outreach to the remotest area of Himachal Pradesh-India, a first-hand experience
Authors: Sharma Gopal Ashish , Rattan Saurabh , Jindal Nipun , Kumar Rahul , Gupta Gurdarshan 
Published: June 2024

Background: The COVID-19 vaccination drive Himachal Pradesh (HP), lead from the front by vaccinating 50,21,659 eligible beneficiaries for the 1st dose. Govt of India had given target of saturating the state with the first dose by the end of the month. By 16th of August, 2021, Distt Kangra had already administered 10.73+ lakh doses covering 92.2% of the eligible target. Objective: The target would not be achieved factually without considering the vaccination in far-flung remote village of ‘Bara Bangal’. Methods: The village is sandwiched between two passes. The most accessible access is located behind the scenic ‘Dhauladhar mountain ranges, following vigorous trails for 3 days.The target of 100% for the 1st dose could not be achieved without vaccinating the left-out beneficiaries. Hence, extra efforts were made to vaccinate estimated 120 beneficiaries. The Chief Minister’s Office approved for the proposed vaccination team outreach session at ‘Bara Bangal’, Kangra, by the state-owned helicopter. Authorities decided to take 20 vials of the Covishield vaccine with a team of 5 individuals. Results: The team vaccinated 111 beneficiaries at ‘Bara Bangal’ out of which 103 were administered the ‘first’ and eight were administered the 'second' due dose. This dedicated vaccine campaign is a landmark event in the HP vaccination coverage of the entire population for the 1st dose. Interpretation: A coordinated and committed effort by the state authorities thereby ensured vaccine equity against all odds, as inaccessible one’s of the remotest areas were outreached & vaccinated. On the 29th of August, HP became the 1st state in India to achieve a 100% vaccination of the eligible population. The state has ensured that no one is left out even from remotest area.
Kurikulum Terpadu Di SMA Plus Al-Aqsha Jatinangor: Studi Analisis Keterpaduan Nilai-Nilai Islam
Authors: Lestari Ria , Rahmat Munawar , Afriatien Toto Suryana 
Published: June 2024

Penelitian ini dilatar belakangi oleh kurangnya penerapan nilai-nilai Islam dalam penggunaan kurikulum di sekolah. Kurikulum sendiri merupakan seperangkat rancangan pembelajaran yang dibuat guna mencapai tujuan dalam sebuah pendidikan. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif yang ditelusuri melalui wawancara dan studi dokumen guna mendapatkan data penelitian. Informan yang terlibat dalam wawancara ini adalah kepala sekolah, wakasek kurikulum uum dan pesantren, guru Bahasa Indonesia dan juga guru Bahas Sunda dari SMA Plus Al- Aqsha Jatinangor. Berdasarkan hasil penelitian SMA Plus Al-Aqsha merupakan sekolah berbasis pesantren atau boarding school yang memadukan 4 kurikulum diantaranya kurikulum umum ,kurikulum KMMI (Kuliyyatul Mualimin wal Mualimat al-Islamiyah), kurikulum salafi, dan kurikulum tahfidz. Dalam menjalankan kegiatan di SMA Plus Al-Aqsha tidak terlepas dari nilai-nilai Islam seperti niali aqidah, nilai syariah dan nilai akhlak. Meskipun terbilang memadukan kurikulum yang tidak sedikit namun itu bukan sebuah kendala karena pembelajaran yang berlangsung tidak hanya mengandalkan pembelajaran secara formal di dalam kelas saja. Dengan penggunaan kurikulum yang terpadu seperti ini justru nilai yang menjadi nilai plus di sekolah ini sehingga para siswanya dapat menerapkan nilai-nilai Islam secara lebih mendalam dalam kegiatan sehari-harinya. Hasil dari penggunaan kurikulum yang terpadu atau terintegrasi ini terlihat dan terasa terdapat perubahan dari para siswa ke arah yang lebih baik terutama dalam segi ibadah dan juga karakter.
„A meseszerűség ködébe burkolt állam”: Zágonyi Sámuel küzdelme a Kanadába irányuló magyar kivándorlás ellen
Authors: Venkovits Balázs 
Published: June 2024

Az 1920-as években, részben az Egyesült Államok bevándorlást korlátozó intézkedései miatt, a Magyarországról kivándorolni szándékozók körében Kanada szerepe erősen felértékelődött. Ezt számos egyéb tényező mellett a Kanadáról szóló olyan beszámolók is erősítették, amelyek célja a bevándorlók országba, elsősorban a nyugati tartományokba való csábítása volt. Zágonyi Sámuel ez ellen vette fel a harcot és egyfajta ellenpontként igyekezett a kanadai kivándorlásról lebeszélni az azon gondolkodókat. Ennek érdekében saját tapasztalatai alapján könyvet írt a kanadai bevándorlók nehéz körülményeiről és országos előadó körútra is indult. A jelen tanulmányban a Bihar vármegyei alispánnak címzett levelei, újságcikkek, könyve, illetve a budapesti Zeneakadémia dísztermében elhangzott előadása elemzésével mutatom be Zágonyi tevékenységét és a hozzá kapcsolódó kérdéseket, újfajta betekintést adva az 1920-as évek magyar kivándorlásának történetébe.
Peran Usaha-Usaha Kecil Di Palembang Terhadap Perekonomian Nasional
Authors: Kesya Nafisa Syahira , Albaris Muhammad Syah , Agustina Dini Rosa , Junianda Muhammad , Izzania Thallita , Nada Nayla Syifa 
Published: June 2024

ABSTRACT
The aim of this research is to determine the development of small businesses in Palembang, the development of economic growth in Indonesia, the role and influence of MSMEs on Indonesia's economic growth, as well as the problems faced by MSMEs in Palembang and steps to overcome them. This type of research is literature review research with a qualitative research method approach. The results and conclusions in this research show that the development of MSMEs in Palembang and economic growth in Indonesia tends to increase. The role of MSMEs is expected to expand the provision of employment opportunities, increase income evenly, and increase the competitiveness and resilience of the national economy which supports economic growth. MSMEs also have a significant influence on economic growth in Indonesia. The problems for MSMEs in Palembang are facing a decline in sales/demand, difficulties and expensive raw materials, as well as hampered distribution, capital and production operations. This problem can be overcome by Microfinance Institutions.
ABSTRAK
Tujuan penelitian ini adalah untuk mengetahui perkembangan usaha kecil di Palembang, perkembangan pertumbuhan ekonomi di Indonesia, peran dan pengaruh UMKM terhadap pertumbuhan ekonomi Indonesia, serta permasalahan yang dihadapi UMKM di Palembang dan langkah mengatasinya. Jenis penelitian ini adalah penelitian studi pustaka (literature review) dengan pendekatan metode penelitian kualitatif. Hasil dan kesimpulan dalam penelitian ini menunjukkan bahwa Perkembangan UMKM di Palembang dan pertumbuhan ekonomi di Indonesia cenderung mengalami peningkatan. Peran UMKM diharapkan dapat memperluas penyediaan lapangan kerja, pemerataan peningkatan pendapatan, serta meningkatkan daya saing dan ketahanan perekonomian nasional yang mendukung pertumbuhan ekonomi. UMKM juga memiliki pengaruh yang signifikan terhadap pertumbuhan ekonomi di Indonesia. Permasalahan UMKM di Palembang yaitu menghadapi penurunan penjualan/permintaan, kesulitan dan mahalnya bahan baku, serta terhambatnya operasional distribusi, permodalan, dan produksi. Permasalahan tersebut dapat diatasi dengan Lembaga Keuangan Mikro (LKM)
Professional Development and Teachers' Digital Art Toward Enhanced Instructional Skills
Authors: Lin Xinyao 
Published: June 2024

Incorporating digital art into educational curricula confronts art teachers with both prospects and difficulties, necessitating a constant improvement of their teaching abilities to address the changing requirements of students in the digital era. This research assessed the professional development and digital art teaching skills of art instructors to identify areas that need improvement and to guide the construction of an expanded instructional program. The results indicate that art instructors typically consider professional development opportunities to be helpful. However, their proficiency in digital art education is assessed as average in many areas, such as technical expertise, digital art approaches, and media literacy. Furthermore, a notable and favorable association was discovered between the professional growth of art instructors and their proficiency in instructing digital art. This underscores the need of continuous training and improving their abilities. These results suggest the need for an Enhanced Digital Art Instructional Skills Program, which aims to provide art instructors with the necessary skills to conduct effective and ethically acceptable digital art education. This curriculum prioritizes the development of technical skills, expertise in teaching methods, ethical awareness, and cooperation among educators to promote the growth of creativity, critical thinking, and digital literacy in students. Assessment and feedback procedures will be put in place to evaluate the program's efficacy and guarantee ongoing enhancement.