bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulsed-field- vs. cryoballoon-based pulmonary vein isolation: lessons from repeat procedures
Authors: Lemoine Marc D , Obergassel Julius , Jaeckle Sandro , Nies Moritz , Taraba Sophia , Mencke Celine , Rieß Jan , My Ilaria , Rottner Laura , Moser Fabian , Ismaili Djemail , Reißmann Bruno , Ouyang Feifan , Kirchhof Paulus , Rillig Andreas , Metzner Andreas 
Published: August 2024

Abstract

Aims
Pulsed-field ablation (PFA) is an emerging technology to perform pulmonary vein isolation (PVI). Initial data demonstrated high safety and efficacy. Data on long-term PVI durability and reconduction patterns in comparison to established energy sources for PVI are scarce. We compare findings in repeat ablation procedures after a first PFA to findings in repeat ablation procedures after a first cryoballoon ablation (CBA) based PVI.

Methods and result
A total of 550 consecutively enrolled patients underwent PFA or CBA index PVI. Repeat ablations in patients with symptomatic atrial arrhythmia recurrences were analysed. A total of 22/191 (12%) patients after index PFA-PVI and 44/359 (12%) after CBA-PVI underwent repeat ablation. Reconduction of any pulmonary vein (PV) was detected by multipolar spiral mapping catheter at each PV with careful evaluation of PV potentials and by 3D-mapping in 16/22 patients (73%) after PFA-PVI and in 33/44 (75%) after CBA-PVI (P = 1.000). Of 82 initially isolated PVs after PFA-PVI, 31 (38%) were reconducting; of 169 isolated PVs after CBA-PVI, 63 (37%) were reconducting (P = 0.936). Clinical atrial tachycardia occurred similarly in patients after PFA (5/22; 23%) and CBA (7/44; 16%; P = 0.515). Roof lines were set more often after PFA- (8/22; 36%) compared with CBA-PVI (5/44; 11%; P = 0.023). Repeat procedure duration [PFA: 87 (76, 123) min; CBA: 93 (75, 128) min; P = 0.446] was similar and fluoroscopy time [PFA: 11 (9, 14) min; CBA: 11 (8, 14) min; P = 0.739] equal between groups at repeat ablation.

Conclusion
During repeat ablation after previous PFA- or CBA-based PVI, electrical PV-reconduction rates and patterns were similar.
Using Euf1 transcription factor as a titrator of erythritol-inducible promoters in Yarrowia lipolytica; insight into the structure, splicing, and regulation mechanism
Authors: Celińska Ewelina , Korpys-Woźniak Paulina , Gorczyca Maria , Nicaud Jean-Marc 
Published: August 2024

Abstract
Controllable regulatory elements, like inducible, titratable promoters, are highly desired in synthetic biology toolboxes. A set of previously developed erythritol-inducible promoters along with an engineered Yarrowia lipolytica host strain were shown to be a very potent expression platform. In this study, we push the previously encountered limits of the synthetic promoters’ titratability (by the number of upstream motifs) by using a compatible transcription factor, Euf1, as the promoter titrator. Overexpression of spliced EUF1 turned out to be very efficient in promoting expression from the compatible promoter, however, the erythritol-inducible character of the promoter was then lost. Analysis of the EUF1’s splicing pattern suggests that the intron removal is promoted in the presence of erythritol, but is not dependent on it. The 3D structures of spliced versus unspliced Euf1 were modeled, and ligand-binding strength was calculated and compared. Furthermore, the EUF1-dependent expression profile under different chemical stimulants was investigated. Depletion of carbon source was identified as the significant factor upregulating the expression from the Euf1-dependent promoter (2–10-fold). Considering these findings and transcriptomics data, a new mechanism of the Euf1-regulated promoter action is proposed, involving a ‘catabolite repression’ transcription factor—Adr1, both acting on the same ERY-inducible promoter.
Unveiling pepper immunity’s robustness to temperature shifts: insights for empowering future crops
Authors: Billaud William , Hirsch Judith , Ribaut Valentin , Tamisier Lucie , Massire Anne , Szadkowski Marion , Lopez-Lauri Félicie , Moury Benoît , Lefebvre Véronique 
Published: August 2024

Abstract
Boosting plant immunity is an effective alternative to pesticides. However, environmental variations, accentuated by climate change, can compromise immunity. The robustness of a trait corresponds to the absence (or low level) of variation in that trait in the face of an environmental change. Here, we examined two types of robustness, robustness of immunity mean and robustness of immunity variation, and proposed nine quantitative robustness estimators. We characterized the immunity of a set of accessions representative of the natural diversity of pepper (Capsicum annuum L.), to two major pathogens: the oomycete Phytophthora capsici Leon. and potato virus Y. For each pathogen, we measured the immunity of accessions in two contrasting environments in terms of temperature. For each type of robustness and each pathogen, the impact of temperature change on immunity varied between accessions. The robustness estimators proved to be complementary and differed in terms of heritability and ability to discriminate accessions. A positive and significant correlation was observed between immunity and robustness. There was no significant relationship between the robustness of immunity to the two pathogens, but some accessions showed high immunity and robustness against both pathogens. These results justify the need to consider both immunity and robustness to environmental variations in order to select varieties adapted to current and future climate conditions. Phenotypic robustness should also be considered when assessing the “value of sustainable cultivation and use” of future plant varieties, particularly during the application process for protection rights granted from the European Community Plant Variety Office.
Self-Compassion in Adolescents and Young Adults With Inflammatory Bowel Disease: Relationship of Self-Compassion to Psychosocial and Physical Outcomes
Authors: Neiman Nicole , Boothroyd Derek , Anjur Kavya , Bensen Rachel , Yeh Ann Ming , Wren Ana Vanessa A 
Published: August 2024

Abstract

Background
Adolescents and young adults (AYAs) diagnosed with inflammatory bowel disease (IBD) are at an increased risk for poor physical and mental health due to the complexity of pediatric onset IBD and the unique developmental challenges of this period of life. Self-compassion is increasingly recognized as having an important role in explaining health outcomes and well-being across a range of populations. This study examines the relationship between self-compassion and psychosocial and physical health outcomes in AYAs with IBD.

Methods
In this cross-sectional study, AYAs with IBD aged 15 to 25 years completed an online survey between February 2020 and October 2021. Questionnaires included the Self-Compassion Scale—Short Form, Patient-Reported Outcomes Measurement Information System (PROMIS) measures for psychosocial, physical and global health outcomes, and IBD disease activity indices.

Results
AYAs with higher levels of self-compassion were found to have better psychosocial (ie, anxiety, depressive symptoms, psychological stress, physical stress, peer relationships), physical (ie, fatigue), and global health outcomes. Self-compassion was a significant independent predictor of anxiety (β = −5.80, P = &lt; .001), depressive symptoms (β = −7.09, P = &lt; .001), psychological stress (β = −4.66, P = &lt; .001), physical stress (β = −3.19, P = &lt; .001), peer relationships (β = 3.39, P = .003), fatigue (β = −2.05, P = .019), and improved global health (β = 5.15, P = &lt; .001).

Conclusions
This study offers preliminary support for the importance of self-compassion in AYAs with IBD and demonstrates the need for further research in this area.
Managing flexibility in supply chains: mathematical analysis of dual sourcing systems
Authors: Devalkar Sripad K , Seshadri Sridhar 
Published: August 2024

Abstract
Accepted by: Konstantinos Nikolopoulos
The COVID 19 pandemic forced supply chain managers to explore different ways to cope with rapid changes in supply, manufacturing, distribution and demand. The lessons learnt from that experience is that flexibility in responding to demand and modularity must be planned at every stage. Along with planning, we argue that execution becomes challenging and is equally important to consider when making plans. We illustrate with a broad category of flexibility and modularity, dual sourcing, and how management mathematics can be used to manage these systems and understand the cost of execution. Dual sourcing has been used to manage the trade-off between cost and responsiveness by firms and has received considerable attention in academic literature. It is known that except in special cases, the optimal sourcing policy does not have an easy structure that is practically appealing and can be used by managers. Over the last decade and half, researchers have developed various management mathematics techniques and analyzed the performance of heuristic policies. This paper presents a discussion of the results in a few key papers related to the dual-sourcing inventory management problem and recent distribution free results in asymptotic regions. The asymptotic regimes considered include systems where the lead-time from the slower supplier is significantly higher than that from the closer, faster supplier and conditions where the unit cost of procurement is significantly higher compared to the unit cost of carrying inventory. These regimes represent different conditions about how valuable or costly using the faster supplier is and illustrate the value of simple heuristic policies and characterize the cost of these heuristics. The key learnings are that optimal ordering decisions may be robust to misspecification of demand distribution and managers only need summary statistics, such as the average and standard deviation of demand to determine the order quantities from the different suppliers. Managers could also consider ways to roll out new planning and control systems for managing multiple suppliers.
Forum: Dead-Ends, Disasters, Delays? Reflecting on Research Failure in International Studies and Ways to Avoid It
Authors: Meibauer Gustav , Renic Neil C , Rodehau-Noack Johanna , Braun Christian Nikolaus , Davis Amber , Glencross Andrew , Vaha Milla , Temel Vuslat Nur Şahin , Hartnett Liane , Andrä Christine , Smith Karen E 
Published: August 2024

Abstract
This forum urges international relations (IR) practitioners to rethink the nature of both failure and success, and their own responsibility in building an academy that enables scholars of all backgrounds to thrive. Reflecting on their own experiences, the contributors detail factors that commonly stymie promising work in IR. These range from the quotidian—rejections during peer review and frustrations around network-building—to more serious impediments, including the growing neoliberalization of the academy, employment precarity, illness and disability, and limits on academic freedom. The forum offers four central insights: First, we must recognize the difference between constructive and non-constructive research failure and create greater space for the former. Second, we must work harder to identify and address those contributors to research failure that should not be tolerated. This includes a recognition of privilege and positionality and an understanding of failure as fundamentally situational. Concurrently, third, we must also resist narratives that fetishize meritocracy and individual resilience, and render invisible structural barriers to success. Finally, we must better distinguish researcher failure from research failure. The barriers that slow or foreclose promising research harm not only our intellectual community but also our discipline, limiting its potential to address the most significant challenges of the present moment.
When sexual distress shares the bed: the role of sexual self-esteem in the relationship between dispositional mindfulness and sexual distress in sex therapy patients
Authors: Godbout Natacha , Martel Nadia Willard , Gewirtz-Meydan Ateret , Girard Marianne , Hébert Martine 
Published: August 2024

Abstract

Background
Sexual distress (eg, feeling distressed, unhappy, frustrated, stressed, dissatisfied, or bothered about their sexuality) is a central concern reported by patients seeking sex therapy, and might be related to sexual self-esteem and mindfulness disposition, yet research is needed to examine the links among those variables within the specific population of patients seeking therapy.

Aim
This study aimed to examine the indirect role of sexual self-esteem in the relationship between dispositional mindfulness and sexual distress.

Methods
The study was conducted among 696 patients undergoing sexual therapy (mean age 34.19 ± 11.21 years, age range 18-78 years). Participants identified as women (57.3%), men (38.5%), or nonbinary (4.2%). They completed self-report questionnaires assessing dispositional mindfulness (Five Facet Mindfulness Questionnaire), sexual self-esteem (Multidimensional Sexuality Questionnaire), and sexual distress (Sexual Distress Scale–Revised), during their first few sessions (ie, first to third sessions [the assessment phase]).

Outcomes
Sexual distress was the main outcome, as measured with the Sexual Distress Scale–Revised.

Results
Results indicated that 54% (n = 376) of patients reported elevated sexual distress based on the questionnaire threshold score. Path analyses indicated an indirect effect in which higher dispositional mindfulness was associated with higher levels of sexual self-esteem, which in turn was associated with lower sexual distress. Results also highlighted that specific facets of mindfulness were related to higher sexual self-esteem (ie, describing, and nonreacting) and lower sexual distress (ie, nonjudgment and acting with awareness). The integrative model explained 23% of the variance of sexual distress scores.

Clinical Implication
Findings suggest that addressing specifically sexual self-esteem and mindfulness may represent relevant clinical avenues to reduce sexual distress among sex therapy patients.

Strengths and Limitations
Strengths of this study include the novel examination of the role of sexual self-esteem in the link between mindfulness disposition and sexual distress in a large clinical sample of patients seeking sex therapy. Limitations includes reliance on patient self-report and a cross-sectional design that limit conclusion regarding causality.

Conclusion
This study makes a valuable contribution to the existing body of research highlighting the pivotal roles of sexual self-esteem in the link between dispositional mindfulness and reduced sexual distress among adults undergoing sex therapy, allowing us to identify potential targets of intervention.
Non-specific phospholipase C3 is involved in endoplasmic reticulum stress tolerance in Arabidopsis
Authors: Ngo Anh H , Angkawijaya Artik Elisa , Nakamura Yuki , Kanehara Kazue 
Published: August 2024

Abstract
Non-specific phospholipase C (NPC) is an emerging family of lipolytic enzymes unique to plants and bacteria that play crucial roles in growth and stress responses. Among six copies of NPC isoforms found in Arabidopsis, the role of NPC3 remains elusive to date. Here, we show that NPC3 is a functional non-specific phospholipase C involved in tolerance to tunicamycin (TM)-induced endoplasmic reticulum (ER) stress through the synthesis of phosphocholine (PCho), a reaction product of NPC3. The npc3 mutant exhibited reduced sensitivity to TM treatment. Recombinant NPC3 possessed pronounced phospholipase C activity that hydrolyses phosphatidylcholine (PC). The hyposensitivity of npc3 to TM treatment was complemented by exogenous PCho, suggesting that NPC3-catalysed PCho production is involved in TM-induced ER stress tolerance. NPC3 was localized at the ER and was predominantly expressed in the roots, and it was further induced by TM-induced ER stress. Intriguingly, npc3 mutants showed a markedly reduced PCho content in shoots under ER stress. Our results indicate that ER stress induces NPC3 to produce PCho, which is involved in TM-induced ER stress tolerance.
The role of lysophosphatidic acid acyltransferase 1 in reproductive growth of Arabidopsis thaliana
Authors: Barroga Niña Alyssa M , Nguyen Van C , Nakamura Yuki 
Published: August 2024

Abstract
Lysophosphatidic acid acyltransferase1 (LPAT1) catalyzes the second step of de novo glycerolipid biosynthesis in chloroplasts. However, the embryonic-lethal phenotype of the knockout mutant suggested an unknown role for LPAT1 in non-photosynthetic reproductive organs. Reciprocal genetic crossing of the lpat1-1 heterozygous line suggested a female gametophytic defect of the lpat1-1 knockout mutant. By suppressing LPAT1 specifically during seed development, we showed that LPAT1 suppression affected silique growth and seed production. Glycerolipid analysis of the LPAT1 knockdown lines revealed a pronounced decrease of phosphatidylcholine (PC) content in mature siliques along with an altered polyunsaturation level of the polar glycerolipids. In seeds, the acyl composition of triacylglycerol (TAG) was altered albeit not the content. These results indicate that plastidic LPAT1 plays an important role in reproductive growth and extraplastidic glycerolipid metabolism involving PC and TAG.
Patent Litigation in China
Authors: Xu Alan 
Published: August 2024

Abstract
This chapter talks about how the Chinese Patent Law was first enacted in 1984 when China adopted the national policy of reform and opening up. Most of the terms, concepts, and principles under the Patent Law were directly transplanted from western countries and were adapted to China's special national conditions. It cannot be overstated that in patent law, “the name of the game is the claim.” Patent claims are the touchstones of patent protection, what is often referred to as the “metes and bounds” of the patentee's protected interest. Claims are comprised of words, and the words must be given meaning (or interpreted). Therefore, patent claim interpretation is the first step for the analysis of patent infringement — to identify the scope of patent rights.
Competition Law and Industrial Policy in China
Authors: Ong Burton , Tao Tao 
Published: August 2024

Abstract
This chapter explores how competition law and industrial policy necessarily operate within jurisdiction-specific economic, political, and social contexts, resulting in legal frameworks which incorporate broader policy considerations that determine the specific contours of the legal prohibitions against anti-competitive conduct. As a rapidly developing economy with ambitious industrialization goals, China provides a good example of the nexus between competition law and industrial policy in the last decade when its cross-sectoral AML came into force. The chapter examines the interaction between China's competition law and industrial policy frameworks, focusing on how its competition authorities and courts have applied the AML to cases with broader national economic implications.
The Oligopoly Problem in Competition Law
Authors: Lianos Ioannis , Korah Valentine , Siciliani Paolo 
Published: August 2024

Abstract
This chapter examines the oligopoly problem in EU and UK competition law. It first provides an overview of the main oligopolistic models used in competition law and game theory before discussing the economics of collusion and how collusion differs from uncoordinated competitive rivalry. It then considers ‘unilateral effects’ caused by a merger between two competitors and how they can be balanced by efficiency improvements of the merged entity. It also describes the main models of oligopolistic (uncoordinated) competition, the challenges involved in designing a competition law regime that would tackle the harmful effects of oligopoly, and the limits of Article 101 TFEU and Chapter I CA 1998 with regard to the communications-based approach to collusion. The chapter concludes with an analysis of concerted practices and parallel conduct, noting that collusion will not be inferred from parallel conduct unless it does not make commercial sense otherwise.
Supplement to Chapter 9
Authors: Lianos Ioannis , Korah Valentine , Siciliani Paolo 
Published: August 2024

Abstract
This supplement to Chapter 9 presents case studies on abuse of a dominant position, beginning with NV Nederlandsche Banden Industrie Michelin v Commission (1983), in which the European Commission ruled that Michelin's incentive rebates constituted an abuse of its dominant position over the supply of tyres for heavy vehicles in the Netherlands to retailers for the replacement market, to the exclusion of retreads. Also discussed is Commission's decision in 2001 that Michelin had abused its dominant position in the French markets for new replacement tyres and retreaded tyres for heavy vehicles by implementing a complex pricing system, along with the case of Intel Corp. that highlights the condition of exclusivity (de jure or de facto) and how it raises the anticompetitive problem of rebates.
Choice-of-court Agreements under the European and International Instruments
Authors: Hartley Trevor C 
Published: August 2024

Abstract
The Hague Convention on Choice of Court Agreements came into force on 1 October 2015. This online-only update considers the changes that the Convention will introduce, as well as recent case law affecting choice-of court agreements considered in the original text. The Convention, while excluding insurance contracts in general, makes a number of significant exceptions to this category in the interests of consumer and business protection, which this online-only update reviews in detail. The update also considers recent cases and developments in jurisdiction, asymmetric choice-of-court agreements, potential benefits to third parties, electronic communications, and damages for unlawful litigation.
Update to Chapter 16: Recognition and Enforcement of Judgments
Authors: Hartley Trevor C 
Published: August 2024

Abstract
This chapter provides an overview of recognition and enforcement of judgments. The relevant provisions in Brussels and Lugano are in Chapter III of each instrument (and for authentic instruments and court settlements, Chapter IV); in Hague, the relevant provisions are in Chapter III. These provisions apply only to judgments, authentic instruments, and court settlements from States covered by the instrument in question. Under Brussels and Lugano, the basic principle is that every judgment from the courts of another EU or Lugano State should be recognized and, where appropriate, enforced. Non-recognition or non-enforcement is the exception. As a result, in determining whether a particular judgment should be recognized and enforced, one does not start by considering the requirements for recognition in order to see whether they are satisfied. Instead, one looks at the grounds for non-recognition to see whether any of them applies.
Jurisdiction in Matters of Parental Responsibility—Chapter II, Section 2
Authors: Wilderspin Michael 
Published: August 2024

Abstract
This chapter tackles the jurisdiction surrounding parental responsibility under the Brussels IIb Regulation. It mentions how the Regulation’s Chapter II, Section 2 underwent significant changes as the issue of child abduction has been moved to its chapter, while its special provision on retention of jurisdiction in the case of international child abduction remains. Article 7(1) is the cornerstone of the system of jurisdiction applicable in matters of parental responsibility concerning the criterion of proximity, which is subject to certain exceptions. Additionally, Article 21 provides for the right of the child to express their views. The chapter explains how Brussels IIb Regulation contains no rules on the designation of the law applicable in matters of parental responsibility, but all the Member States are Contracting Parties to the 1996 Child Protection Convention.