bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIRT1 silencing promotes EMT and Crizotinib resistance by regulating autophagy through AMPK/mTOR/S6K signaling pathway in EML4‐ALK L1196M and EML4‐ALK G1202R mutant non‐small cell lung cancer cells
Authors: Yang Qian , Sun Keyan , Gao Tianyu , Gao Ying , Yang Yuying , Li Zengqiang , Zuo Daiying 
Published: July 2024

AbstractMost EML4‐ALK rearrangement non‐small cell lung cancer (NSCLC) patients inevitably develop acquired drug resistance after treatment. The main mechanism of drug resistance is the acquired secondary mutation of ALK kinase domain. L1196M and G1202R are classical mutation sites. We urgently need to understand the underlying molecular mechanism of drug resistance to study the therapeutic targets of mutant drug‐resistant NSCLC cells. The silent information regulator sirtuin1 (SIRT1) can regulate the normal energy metabolism of cells, but its role in cancer is still unclear. In our report, it was found that the SIRT1 in EML4‐ALK G1202R and EML4‐ALK L1196M mutant drug‐resistant cells was downregulated compared with EML4‐ALK NSCLC cells. The high expression of SIRT1 was related to the longer survival time of patients with lung cancer. Activation of SIRT1 induced autophagy and suppressed the invasion and migration of mutant cells. Further experiments indicated that the activation of SIRT1 inhibited the phosphorylation level of mTOR and S6K by upregulating the expression of AMPK, thus activating autophagy. SIRT1 can significantly enhanced the sensitivity of mutant cells to crizotinib, improved its ability to promote apoptosis of mutant cells, and inhibited cell proliferation. In conclusion, SIRT1 is a key regulator of drug resistant in EML4‐ALK L1196M and G1202R mutant cells. SIRT1 may be a novel therapeutic target for EML4‐ALK drug resistant NSCLC.
Team Science Approaches to Unravel Monogenic Parkinson's Disease on a Global Scale
Authors: Junker Johanna , Lange Lara M. , Vollstedt Eva‐Juliane , Roopnarain Karisha , Doquenia Maria Leila M. , Annuar Azlina Ahmad , Avenali Micol , Bardien Soraya , Bahr Natascha , Ellis Melina , Galandra Caterina , Gasser Thomas , Heutink Peter , Illarionova Anastasia , Kanana Yuliia , Keller Sarmiento Ignacio J. , Kumar Kishore R. , Lim Shen‐Yang , Madoev Harutyun , Mata Ignacio F. , Mencacci Niccolò E. , Nalls Mike A. , Padmanabhan Shalini , Shambetova Cholpon , Solle J. C. , Tan Ai‐Huey , Trinh Joanne , Valente Enza Maria , Singleton Andrew , Blauwendraat Cornelis , Lohmann Katja , Fang Zih‐Hua , Klein Christine ,   the Global Parkinson's Genetics Program (GP2)
Published: July 2024

AbstractBackgroundUntil recently, about three‐quarters of all monogenic Parkinson's disease (PD) studies were performed in European/White ancestry, thereby severely limiting our insights into genotype–phenotype relationships at a global scale.ObjectiveTo identify the multi‐ancestry spectrum of monogenic PD.MethodsThe first systematic approach to embrace monogenic PD worldwide, The Michael J. Fox Foundation Global Monogenic PD Project, contacted authors of publications reporting individuals carrying pathogenic variants in known PD‐causing genes. In contrast, the Global Parkinson's Genetics Program's Monogenic Network took a different approach by targeting PD centers underrepresented or not yet represented in the medical literature.ResultsIn this article, we describe combining both efforts in a merger project resulting in a global monogenic PD cohort with the buildup of a sustainable infrastructure to identify the multi‐ancestry spectrum of monogenic PD and enable studies of factors modifying penetrance and expressivity of monogenic PD.ConclusionsThis effort demonstrates the value of future research based on team science approaches to generate comprehensive and globally relevant results. © 2024 State of New South Wales and The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Strategies to Manage Poorer Outcomes After Hip or Knee Arthroplasty: A Narrative Review of Current Understanding, Unanswered Questions, and Future Directions
Authors: Karimijashni Motahareh , Ramsay Tim , Beaulé Paul E. , Poitras Stéphane 
Published: July 2024

ABSTRACTPurposeAlthough hip or knee arthroplasty is generally a successful intervention, it is documented that 15%–30% of patients undergoing arthroplasty report suboptimal outcomes. This narrative review aims to provide an overview of the key findings concerning the management of poorer outcomes after hip or knee arthroplasty.MethodA comprehensive search of articles was conducted up to November 2023 across three electronic databases. Only studies written in English were included, with no limitations applied regarding study design and time.ResultEfficiently addressing poorer outcomes after arthroplasty necessitates a thorough exploration of appropriate methods for assessing recovery following hip or knee arthroplasty, ensuring accurate identification of patients at risk or experiencing poorer recovery. When selecting appropriate outcome measure tools, various factors should be taken into consideration, including understanding patients' priorities throughout the recovery process, assessing psychometric properties of outcome measure tools at different time points after arthroplasty, understanding how to combine/reconcile provider‐assessed and patient‐reported outcome measures, and determining the appropriate methods to interpret outcome measure scores. However, further research in these areas is warranted. In addition, the identification of key modifiable factors affecting outcomes and the development of interventions to manage these factors are needed.ConclusionThere is growing attention paid to delivering interventions for patients at risk or not optimally recovering following hip or knee arthroplasty. To achieve this, it is essential to identify the most appropriate outcome measure tools, factors associated with poorer recovery and management of these factors.
Robust tensor recovery via a nonconvex approach with ket augmentation and auto‐weighted strategy
Authors: Xie Wenhui , Ling Chen , He Hongjin , Zhang Lei‐Hong 
Published: July 2024

AbstractIn this article, we introduce a nonconvex tensor recovery approach, which employs the powerful ket augmentation technique to expand a low order tensor into a high‐order one so that we can exploit the advantage of tensor train (TT) decomposition tailored for high‐order tensors. Moreover, we define a new nonconvex surrogate function to approximate the tensor rank, and develop an auto‐weighted mechanism to adjust the weights of the resulting high‐order tensor's TT ranks. To make our approach robust, we add two mode‐unfolding regularization terms to enhance the model for the purpose of exploring spatio‐temporal continuity and self‐similarity of the underlying tensors. Also, we propose an implementable algorithm to solve the proposed optimization model in the sense that each subproblem enjoys a closed‐form solution. A series of numerical results demonstrate that our approach works well on recovering color images and videos.
Determination of the true density and the filler content of pinus sylvestris wood particles in polymer‐wood‐composites
Authors: Bruchmüller Matthias , Puch Florian 
Published: July 2024

AbstractMeasuring the natural fiber content in fiber‐filled polymers remains challenging. Conventional methods, such as density calculations based on the specific bulk densities of the mixed components or determining the remaining fiber weights after calcination, often yield inaccurate results. Even helium pycnometer measurements tend to overestimate the true density of natural fibers. This study introduces a novel and potentially more cost‐effective method to accurately determine the true density of natural filler materials. The approach involves mixing these fillers into plastic melts and injection molding them under pressures up to 1000 bar. Using this method, the true density of Pinus sylvestris heartwood chips combined with a lactic acid polymer was precisely calculated as 1.40092 g/cm3 ± 0.0102 g/cm3. Knowing the true density of material like Pinus sylvestris heartwood offers an accurate calculation of filler content in unknown recycled mixtures. This method can calculate the amount of wood fillers in polymer compounds, such as those from former decking, fences, privacy screens or soundproof wall claddings.Highlights
Precise method to determine specific actual densities of biofillers
High‐resolution CT measurements of polymers filled with wood fibers
Localization of density fluctuations in wood fiber filled polylactide
Methodology for measuring the biofiber content of recyclates
Compression behavior and design optimization of triggered glass fiber reinforced polymer square tubes
Authors: Baykasoğlu Cengiz , Baykasoğlu Adil , Erdin Muhammed Emin , Cetin Erhan 
Published: July 2024

AbstractGlass fiber reinforced polymer (GFRP) composite tubes have become increasingly popular in crashworthiness applications. On the other hand, square section GFRP tubes are prone to damage in a catastrophic failure mode in the early stages of the crushing process. At this point, triggering mechanisms have great potential to ensure deformation in progressive mode and improve the compression performance of GFRP tubes. Motivated by these facts, this paper aims to optimize the compression performance of square GFRP tubes by implementing notch‐type triggering mechanisms. The effects of notch width, number and length on the axial compression response of tubes were investigated to determine the optimal trigger configurations that would maximize specific energy absorption (SEA) and minimize peak crushing force (PCF). Experiments were conducted based on Taguchi L9 orthogonal array design, and Taguchi coupled Weighted Aggregated Sum Product Assessment (WASPAS) method was employed for optimizing multiple responses. The optimization results revealed that the proposed trigger mechanisms induced progressive crushing by preventing catastrophic failure, thereby significantly improving the compression performance of GFRP tubes. In particular, the results showed that the PCF of intact GFRP tube decreased by up to 38%, while SEA increased by up to 130% with the help of proposed trigger mechanism.Highlights
The compression performance of square GFRP tubes improved by notch‐type triggering.
The notch width, length and number were chosen as design parameters.
Taguchi experimental design was used to find the best configuration of design parameters.
The optimum configurations were examined through the entropy‐WASPAS approach.
The results revealed that significant improvements can be achieved using trigger mechanism.
A bio‐based reactive P/N synergistic flame retardant for improving the fire safety and mechanical properties of epoxy resin
Authors: Wang Chenchen , Ren Bin , Ma Rui , Li Xiuyun 
Published: July 2024

AbstractA high‐efficiency bio‐based P/N synergistic flame retardant (PVFD) is synthesized by combining furfurylamine and vanillin. The compound incorporates two different valence states of phosphorus as flame retardant structures, namely phenylphosphoryl dichloride (PPDC) and 9,10‐dihydro‐9‐oxa‐10‐ phosphophenyl‐10‐oxide (DOPO). PVFD and epoxy resin (EP) can cure into a cross‐linked network, thus not only improving the mechanical properties of EP but also achieving P/N synergistic flame retardant effects. Experimental results demonstrate that EP/PVFD‐5 obtained by adding 5 wt% of PVFD to EP passes the UL‐94 test and achieves V‐0 grade, whose limiting oxygen index (LOI) is up to 38.0%. EP/PVFD‐5 exhibits a decrease of 10.14% in peak heat release rate (PHRR), 16.90% in total heat release (THR), and 10.0% in total smoke release (TSP), while the residual carbon content increases by 8.5%. Additionally, the bending strength, bending modulus, tensile strength, and elongation at break of EP/PVFD‐5 increase by 3.9%, 4.9%, 45.1%, and 26.3%, respectively.Highlights
The bio‐based raw materials we used are eco‐friendly and readily available.
PVFD, an efficient P‐N synergistic compound, was synthesized.
PVFD promotes the char formation of EP and dilutes the O2 concentration.
PVFD does not cause the degradation of mechanical properties of EP.
Revisiting Winnow: A modified online feature selection algorithm for efficient binary classification
Authors: Narasimhulu Y. , Kolambkar Pralhad , China Venkaiah V. 
Published: July 2024

AbstractWinnow is an efficient binary classification algorithm that effectively learns from data even in the presence of a large number of irrelevant attributes. It is specifically designed for online learning scenarios. Unlike the Perceptron algorithm, Winnow employs a multiplicative weight update function, which leads to fewer mistakes and faster convergence. However, the original Winnow algorithm has several limitations. They include, it only works on binary data, and the weight updates are constant and do not depend on the input features. In this article, we propose a modified version of the Winnow algorithm that addresses these limitations. The proposed algorithm is capable of handling real‐valued data, updates the learning function based on the input feature vector. To evaluate the performance of our proposed algorithm, we compare it with seven existing variants of the Winnow algorithm on datasets of varying sizes. We employ various evaluation metrics and parameters to assess and compare the performance of the algorithms. The experimental results demonstrate that our proposed algorithm outperforms all the other algorithms used for comparison, highlighting its effectiveness in classification tasks.
47‐2: Invited Paper: Modulated Analog Driving and Evaluation of Image Quality
Authors: Henzen Alex , Rockoff Todd , Caulkins Will 
Published: July 2024

Consumer demand for higher resolution, higher frame rate, and deeper color displays is driving the data rates of the connected video systems to the limits of affordability. At current high‐end displays, like 4K gaming at 360 Hz frame rate or 8K TV's at >120 Hz frame rate, conventional data transports require parallel data‐pairs plus equalization circuits to deliver the required video data. These accommodations increase cost, power and complexity.HYPHY's revolutionary ‘modulated analog' (also referred to as “sampled Analog”) video transport is the solution to this impasse, demonstrably delivering 10X more video payload per “wire‐hertz” than traditional methods, delivering equal or better image quality.To emphasize the advantages of this method, HYPHY has developed an image and video quality measurement method that demonstrates the image quality of Modulated Analog to be at least on par with traditional display driving.
Retrospective analysis of transabdominal preperitoneal hernia repair in emergency cases: A cohort study
Authors: Brucchi Francesco , Pelfini Elisa , Masci Emilia , Limongi Chiara , Cassini Diletta , Faillace Giuseppe 
Published: July 2024

AbstractPurposeThis study aimed to evaluate the feasibility, safety, and efficacy of laparoscopic transabdominal preperitoneal hernia repair (TAPP) for inguinal hernias in emergency settings, providing insights from a long‐term follow‐up.MethodsWe retrospectively analyzed all patients who underwent emergency TAPP repair in ASST Nord Milano from January 2005 to December 2023. A prospectively collected database of 54 consecutive TAPP hernia repairs was reviewed. The study evaluated the feasibility and safety of TAPP through operative time and the conversion rate. Effectiveness was gauged by recurrence and complication rates as well as acute and chronic pain using the Visual Analog Scale (VAS). Long‐term follow‐up included assessing recovery to normal activity.ResultsOverall, data from 54 consecutive patients were analyzed. Median age was 72 (IQR = 11), with 21 men and 33 women (38.8% vs. 61.2%). The primary diagnosis was a primary hernia (61.1%), while a recurrent type was identified in 21 patients (38.9%). Femoral hernia was identified in 36 cases (48%). The median operative time was 100 min (IQR = 53 min) with 6 cases of conversion (11.1%). One recurrence (1.85%) was noted and the complication rate was 5.55 %. At a median follow‐up of 38 months, there was a low grade of chronic pain (VAS 3) in a patient (1.85%) and one recurrence (1.85%).ConclusionTAPP is a safe, feasible, and effective option for emergency inguinal hernia repair, exhibiting low complication and recurrence rates on long‐term follow‐up when performed by surgeons with minimally invasive surgery experience and in selected patients.
Opportunity Recognition and Innovative Solutions to Societal Challenges: The Case of Community Cooperatives in Italy
Authors: Maiolini Riccardo , Ramus Tommaso 
Published: July 2024

AbstractIn this chapter, we present some preliminary, exploratory evidence concerning the peculiarities surrounding the recognition of entrepreneurial opportunities as encountered by community cooperatives, that is, entities established with the mission to create value for the community in which they operate and not for their members exclusively. Drawing from the experience of eight Italian community cooperatives, we offer initial empirical support to the argument that community embeddedness complicates the process of entrepreneurial opportunity recognition. Community cooperatives confront the challenge of accommodating the disparate needs of community members, while operating within a context of resource constraints. However, community embeddedness also favors the engagement of community members in more creative processes to identify more innovative solutions to empower communities. Our preliminary findings speak to the emergent research on community-based enterprises and to the broader stream investigating entrepreneurship. They also show how cooperatives can be a source of social innovation while anchoring themselves to their imprinting of human-centered organizations, established to ameliorate the conditions of marginalized people.
Cooperative Approaches as a Way to Build Resilient Societies
Authors: Edel Friederike , Grund Maximilian , Moebius Johanna , Schuster Armin , Stork Werner 
Published: July 2024

AbstractThis chapter takes a deeper look into the impact of cooperative approaches within modern societies, especially of the transformation into resilient responsible societies. Therefore, we discuss the background and the development of resilience at individual, organizational, and societal levels. Especially the societal resilience needs to be more specified and examined. We place as a central assumption that every citizen is a co-producer of resilience in the state and in society. The cooperative approach can deliver many impulses needed. We are taking a look at the similarities and differences between cooperatives and all forms of resilient organizations.
Circular Business Model Innovation: New Avenues and Game Changers
Authors: Bocken Nancy M. P. 
Published: July 2024

AbstractCircular business model innovation is about innovating the business model to create superior customer value propositions, while slowing resource loops through products that last longer, closing resource loops, by recycling materials, narrowing the loop by using less material per product and in manufacturing processes, and regenerating resource loops through using renewables and creating benefits for the natural environment. Despite the potential, and emerging circular business model examples by companies, only a limited percentage of products and materials is currently recycled, let alone repaired, or refurbished. This chapter addresses new avenues and game changers for research and practice in circular business model innovation, including: the twin transition of digital and circular economies, slowing the loop and regeneration, collaborative business models, and tools, methods, and impact assessment.
The Twin Advantage: Leveraging Digital for Sustainability in Business Models
Authors: Aagaard Annabeth , Vanhaverbeke Wim 
Published: July 2024

AbstractThe accelerating depletion of global natural resources and the resultant environmental degradation underscore the urgent need for a paradigm shift towards sustainability. This chapter delves into the concept of the twin transition (TT)—the integration of digitalization with sustainable practices—as a strategic imperative for businesses to address these challenges effectively through twin transition business model innovation. It highlights the European Commission's initiatives, like the European Green Digital Coalition (EGDC), advocating for this integrated approach. The narrative outlines four strategic archetypes for twin transition business model innovation, emphasizing the importance of dynamic capabilities and open innovation in leveraging value through cross-sector collaborations. It examines the micro (operational)-, meso (strategic)-, and macro (economic)-implications of these models, demonstrating how digital tools can optimize resource use and promote circular economy practices. Finally, we explore the managerial implications of advancing twin transition business model innovation and identify key research areas essential for comprehending the transformative impact of digital and sustainable practices on competitive advantage, resilience, and long-term sustainability.
Research on Typical Design Scheme for Mechanized Construction of 220 kV Overhead Transmission Line Foundation
Authors: Zhang Wenxiang , Huang Xiaoyu 
Published: July 2024

AbstractThe level of mechanization of overhead transmission lines is an important symbol of modern power construction. Good design and planning of road construction and typical planning of construction foundation can minimize the disturbance of mechanical equipment to the foundation and reduce the impact on the environment, and improving the reliability of soil and water conservation measures. Based on the sorting of commonly used mechanical construction foundation types in mountainous areas, through equipment research, this paper discuss the typical schemes for temporary road on plain area, coastal area, river area and mountain area, and use the typical design on tower site with different equipment to optimise the arrangement of construction and quantitative evaluation on excavation. The results show that: (1) the scheme of plain area are wooden boards and old tires, the scheme of coastal areas and river area are filling and temporary steel trestle, the scheme of mountain area are expand the original road and excavating new road. (2) The excavation quantity of rock anchor foundation with slope ≤10° is the less than that of pile foundation and micro pile foundation, The excavation quantity of split equipment is less than integral equipment because of the requirement of the road width. (3) the slope is an important factor to the excavation quantity, the excavation quantity of rock anchor foundation with slope 25° is 2.33 times than that on slope 10°. The amount of earthwork on the tower site increases by 2.33 times with slope 25° of split equipment on pile and micro pile foundation.