bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Regioselective 1,4‐ over 1,2‐Addition of 3,3‐Bis(silyl) Allyloxy Lithium to Enals, Enones and Enoates. The Remarkable α‐Effect of Silicon.
Authors: Ye Xincui , Sun Xianwei , Huang Zhenggang , Yang Na , Su Zhishan , Hu Changwei , Song Zhenlei 
Published: October 2014

AbstractThe addition of 3,3‐bis(silyl)allyloxy lithium, generated from enol ether (II), to α,β‐unsaturated carbonyl compounds such as (I), (IV), (VI), and (VIII), proceeds in an 1,4‐ over 1,2‐manner with medium to good regioselectivity, whereas the parent allyloxy lithium species undergoes complete 1,2‐addition.
ChemInform Abstract: An Analysis of the Influences Dictating Regioselectivity in Platinum‐Catalyzed Hydrosilylations of Internal Alkynes.
Authors: Rooke Douglas A. , Menard Zachary A. , Ferreira Eric M. 
Published: October 2014

AbstractA full account on previously published studies of Pt‐catalyzed internal alkyne hydrosilylations is presented.
ChemInform Abstract: Aerobic Double Dehydrogenative Cross Coupling Between Cyclic Saturated Ketones and Simple Arenes.
Authors: Gigant Nicolas , Baeckvall Jan‐E. 
Published: October 2014

AbstractA straightforward one‐pot biomimetic aerobic dehydrogenation/oxidative Heck sequence for the introduction of arenes into the β‐position of saturated cyclic ketones is developed.
ChemInform Abstract: General Allylic C—H Alkylation with Tertiary Nucleophiles.
Authors: Howell Jennifer M. , Liu Wei , Young Andrew J. , White M. Christina 
Published: October 2014

AbstractA general method for intermolecular allylic C—H alkylation of terminal olefins with tertiary nucleophiles is developed employing palladium(II)/bis(sulfoxide) catalysis.
ChemInform Abstract: Mild Rh(III)‐Catalyzed Direct C—H Bond Arylation of (Hetero)Arenes with Arylsilanes in Aqueous Media.
Authors: Lu Ming‐Zhu , Lu Ping , Xu Yun‐He , Loh Teck‐Peng 
Published: October 2014

AbstractA rhodium catalyzed regioselective C‐H bond activation of indoles, pyrroles, and benzenes bearing a directing group is demonstrated allowing direct regioselective arylation with different organosilicon reagents.
ChemInform Abstract: Iron‐Catalyzed π‐Activated C—O Ether Bond Cleavage with C—C and C—H Bond Formation.
Authors: Fan Xiaohui , Cui Xiao‐Meng , Guan Yong‐Hong , Fu Lin‐An , Lv Hao , Guo Kun , Zhu Hong‐Bo 
Published: October 2014

AbstractA novel and efficient protocol is developed for the cross‐coupling of benzyl/allyl ethers with allylsilane using FeCl3 as the catalyst.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Sonogashira Coupling of Aryl Bromides Using Near Stoichiometric Carbon Monoxide.
Authors: Neumann Karoline T. , Laursen Simon R. , Lindhardt Anders T. , Bang‐Andersen Benny , Skrydstrup Troels 
Published: October 2014

AbstractStoichiometric amounts of carbon monoxide is formed in a special COware reactor from a stable fluorene‐type precursor [cf.
ChemInform Abstract: A Reagent‐Controlled SN2‐Glycosylation for the Direct Synthesis of β‐Linked 2‐Deoxy‐Sugars.
Authors: Issa John Paul , Bennett Clay S. 
Published: October 2014

Abstractp‐Toluenesulfonic anhydride activates both 2‐deoxy‐ and 2,6‐deoxy‐sugars in situ as electrophilic species, which react stereoselectively with nucleophilic acceptors to produce β‐anomers exclusively.
ChemInform Abstract: Polystyrene Copolymer Supported by Substituted (1R,2R)‐1,2‐Diphenylethane‐1,2‐diamine‐copper(II) Complexes: A Recyclable Catalyst for Asymmetric Henry Reactions.
Authors: Androvic Ladislav , Drabina Pavel , Panov Illia , Frumarova Bozena , Kalendova Andrea , Sedlak Milos 
Published: October 2014

AbstractThe title catalyst is employed for the reactions of functionalized aldehydes with nitromethane to give 2‐nitroethanols in excellent yields and high enantioselectivities.
ChemInform Abstract: Synthesis of gem‐Difluoromethylene Building Blocks Through Regioselective Allylation of gem‐Difluorocyclopropanes.
Authors: Munemori Daisuke , Narita Kent , Nokami Toshiki , Itoh Toshiyuki 
Published: October 2014

AbstractA regioselective allylation of gem‐difluorocyclopropanes is achieved through an AIBN initiated radical ring‐opening with allyltributyltin.
ChemInform Abstract: Arylalkene Synthesis via Decarboxylative Cross‐Coupling of Alkenyl Halides.
Authors: Tang Jie , Goossen Lukas J. 
Published: October 2014

AbstractAn efficient method for the dicarboxylative cross‐coupling of vinyl bromides with potassium arenecarboxylates is developed using a Pd/Cu‐catalyst system.
ChemInform Abstract: Aminative Umpolung Synthesis of Aryl Vicinal Diamines from Aromatic Aldehydes.
Authors: Liu Xuliang , Gao Ang , Ding Lei , Xu Juan , Zhao Baoguo 
Published: October 2014

AbstractThis new strategy allows the synthesis of various diamine products via formation of Schiff base lithium salts followed by decarboxylation.
ChemInform Abstract: Phenyliodine(III) Diacetate (PIDA) Mediated Synthesis of Aromatic Azo Compounds Through Oxidative Dehydrogenative Coupling of Anilines: Scope and Mechanism.
Authors: Monir Kamarul , Ghosh Monoranjan , Mishra Subhajit , Majee Adinath , Hajra Alakananda 
Published: October 2014

AbstractThis new straightforward, fast, and efficient method also allows the synthesis of synthetically challenging unsymmetrical azobenzenes.
ChemInform Abstract: Synthesis of 5‐Alkyl‐5‐aryl‐γ‐lactams from 1‐Aryl‐Substituted Nitroalkanes and Methyl Acrylate via Michael Addition and Reductive Lactamization.
Authors: Xu Jingjing , Li Xingyao , Wu Jinlong , Dai Wei‐Min 
Published: October 2014

AbstractA general and high yielding synthesis of 5,5‐disubstituted γ‐lactams is developed.
ChemInform Abstract: Nano‐Fe3O4 Encapsulated‐Silica Particles Bearing 3‐Aminopropyl Group as a Magnetically Separable Catalyst for Efficient Knoevenagel Condensation of Aromatic Aldehydes with Active Methylene Compounds.
Authors: Liu Shuo , Ni Yuxiang , Yang Jianguo , Hu Huanan , Ying Anguo , Xu Songlin 
Published: October 2014

AbstractThe preparation of a new 3‐aminopropyl‐functionalized Fe3O4/SiO2 catalyst is described which is used for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds.
ChemInform Abstract: Synthesis of Enantiomerically Enriched Triarylmethanes by Enantiospecific Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Matthew Smitha C. , Glasspoole Ben W. , Eisenberger Patrick , Crudden Cathleen M. 
Published: October 2014

AbstractThe synthesis of enantioenriched dibenzylic boronic esters from benzylic carbamates and arylboronic neopentyl esters (II) is demonstrated.
ChemInform Abstract: 2‐(Aryl‐sulfonyl)oxetanes as Designer 3‐Dimensional Fragments for Fragment Screening: Synthesis and Strategies for Functionalization.
Authors: Morgan Kate F. , Hollingsworth Ian A. , Bull James A. 
Published: October 2014

AbstractNon‐planar 2‐sulfonyl‐oxetanes (II) are prepared by an intramolecular C—C bond formation.
ChemInform Abstract: Stereospecific Functionalization of Iodoaziridines via Unstabilized Aziridinyllithiums Generated by Iodine—Lithium Exchange.
Authors: Boultwood Tom , Bull James A. 
Published: October 2014

AbstractLithium‐iodine exchange on N‐tosyliodoaziridines provides unstabilized aziridinyllithiums, which are trapped with various electrophiles to form cis‐substituted derivatives exclusively.
ChemInform Abstract: Remote Enantioselective Friedel—Crafts Alkylations of Furans Through HOMO Activation.
Authors: Li Jun‐Long , Yue Cai‐Zhen , Chen Peng‐Qiao , Xiao You‐Cai , Chen Ying‐Chun 
Published: October 2014

AbstractAn efficient and novel enantioselective Friedel‐Crafts alkylation of furans with activated alkenes is presented.
ChemInform Abstract: Chemoselective Flow Hydrogenation Approaches to Isoindole‐7‐carboxylic Acids and 7‐Oxa‐bicyclo[2.2.1]heptanes.
Authors: Hizartzidis L. , Tarleton M. , Gordon C. P. , McCluskey A. 
Published: October 2014

AbstractTwo series (VI) and (XI) of norcantharidin analogues are synthesized using continuous flow hydrogenation in key steps.
ChemInform Abstract: Gold(I)‐Catalyzed Intra‐ and Intermolecular Alkenylations of β‐Yne‐pyrroles: Facile Formation of Fused Cycloheptapyrroles and Functionalized Pyrroles.
Authors: Pan Bin , Lu Xiaodong , Wang Chunxiang , Hu Yancheng , Wu Fan , Wan Boshun 
Published: October 2014

AbstractAn efficient gold(I)‐catalyzed alkenylation of β‐alkyne‐substituted pyrroles is reported.
ChemInform Abstract: Synthesis of Substituted γ‐Lactam via Pd(0)‐Catalyzed Cyclization of Alkene‐Tethered Carbamoyl Chloride.
Authors: Chen Chen , Hu Jian , Su Jianhua , Tong Xiaofeng 
Published: October 2014

AbstractA facile protocol is developed for the cyclization of alkene‐tethered carbamoyl chlorides in the presence of NaI to form γ‐lactams bearing an alkyl iodide group.
ChemInform Abstract: Oxidative Annulation of Anilides with Internal Alkynes Using an (Electron‐Deficient η5‐Cyclopentadienyl)Rhodium(III) Catalyst under Ambient Conditions.
Authors: Hoshino Yuki , Shibata Yu , Tanaka Ken 
Published: October 2014

AbstractOptimized reaction conditions including a cyclopentadienyl rhodium catalyst and air as terminal oxidant are developed to allow the synthesis of a wide range of indole derivatives through oxidative annulation of anilides with internal alkynes.
ChemInform Abstract: In situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles.
Authors: Zhu Xing‐Li , Xu Jin‐Hui , Cheng Dao‐Juan , Zhao Li‐Jiao , Liu Xin‐Yuan , Tan Bin 
Published: October 2014

AbstractThis new one‐pot protocol allows the synthesis of a wide range of different substituted and SCF3 functionalized oxindole derivatives under mild condition by using simple starting materials.
ChemInform Abstract: Recyclable Bimetallic CuFe2O4 Nanoparticles: An Efficient Catalyst for One‐Pot Three‐Component Synthesis of Novel Dicyanomethyl‐2‐oxoindolin‐3‐ylthiocarboxylic Acids in a Green Solvent.
Authors: Shakibaei Ghazaleh Imani , Ghahremanzadeh Ramin , Bazgir Ayoob 
Published: October 2014

AbstractThe main advantages of this methodology are high yields, cheap reagents, simple work‐up procedure, and the fully magnetic recoverability of the catalyst, making it a green method.
ChemInform Abstract: Access to the Aeruginosin Serine Protease Inhibitors Through the Nucleophilic Opening of an Oxabicyclo[2.2.1]heptane: Total Synthesis of Microcin SF608.
Authors: Diethelm Stefan , Schindler Corinna S. , Carreira Erick M. 
Published: October 2014

AbstractMicrocin SF608 (I), closely related to marine aeruginosins, is synthesized in 21 steps from a common oxabicyclic building block.
ChemInform Abstract: Catalyst‐Free, Ethylene Glycol Promoted One‐Pot Three Component Synthesis of 3‐Amino Alkylated Indoles via Mannich‐Type Reaction.
Authors: Rajesh U. Chinna , Kholiya Rohit , Satya Pavan V. , Rawat Diwan S. 
Published: October 2014

AbstractA facile protocol, using ethylene glycol as a recyclable promoting medium for the three component reaction of indoles, aldehydes, and amines to form 3‐aminoalkylated indoles, is developed.
ChemInform Abstract: Ti‐Mediated Intramolecular Cyclopropanation of N‐Alkenyl Thioamides: Scope and Mechanistic Study.
Authors: Hermant Fabien , Nicolas Emmanuel , Six Yvan 
Published: October 2014

AbstractTreatment of thioamide substrates with a Grignard reagent and Ti(OiPr)4 results in the formation of bicyclic aminocyclopropanes.
ChemInform Abstract: Metal‐Free TEMPO‐Promoted C(sp3)—H Amination to Afford Multisubstituted Benzimidazoles.
Authors: Xue Ding , Long Ya‐Qiu 
Published: October 2014

AbstractAn efficient, clean, and mild protocol for the title reaction is developed to construct polysubstituted and fused polycyclic benzimidazoles (Xb) as well as benzoxazole (XII).
ChemInform Abstract: Highly Diastereo‐ and Enantioselective Silver‐Catalyzed Double [3 + 2] Cyclization of α‐Imino Esters with Isocyanoacetate.
Authors: Shao Pan‐Lin , Liao Jia‐Yu , Ho Yee Ann , Zhao Yu 
Published: October 2014

AbstractSilver‐catalyzed reaction of cyclic α‐imino esters (I) with two equivalents of isocyanoacetates provides oxazole‐imidazolines in high diastereo‐ and enantiopurity.
ChemInform Abstract: Mild Regiospecific Synthesis of 1‐Alkoxy‐isochromenes Catalyzed by Well‐Defined [Silver(I)(Pyridine‐Containing Ligand)] Complexes.
Authors: Dell'Acqua Monica , Castano Brunilde , Cecchini Clara , Pedrazzini Tommaso , Pirovano Valentina , Rossi Elisabetta , Caselli Alessandro , Abbiati Giorgio 
Published: October 2014

AbstractThe new silver catalysts (AGC) and (ATF) efficiently promote the ring closure reaction of 2‐alkynylbenzaldehydes with primary and secondary alcohols.
ChemInform Abstract: Enantioselective Biomimetic Cyclization of 2′‐Hydroxychalcones to Flavanones.
Authors: Zhang Yan‐Lei , Wang Yong‐Qiang 
Published: October 2014

AbstractIt is demonstrated, that a novel L‐proline derived catalyst facilitates the enantioselective synthesis of flavanones from 2′‐hydroxychalcones with up to 99% e.e.
ChemInform Abstract: Palladium‐Catalyzed Picolinamide‐Directed Acetoxylation of Unactivated γ‐C(sp3)—H Bonds of Alkylamines.
Authors: Li Qiong , Zhang Shu‐Yu , He Gang , Nack William A. , Chen Gong 
Published: October 2014

AbstractN‐Alkylpicolinamide substrates (I) are converted into the corresponding γ‐acetoxylated products in the presence of lithium carbonate, which suppresses the competing intramolecular C‐H amination process.
ChemInform Abstract: Synthesis and Further Rearrangements of 7‐(2‐Cycloalken‐1‐yl)‐8‐quinolinols.
Authors: Toerincsi Mercedesz , Kolonits Pal , Novak Lajos 
Published: October 2014

AbstractThe synthesis of 8‐cycloalkyloxyquinolines (III), their sigmatropic rearrangement to 7‐cycloalkylquinolols (IV) and acid‐catalyzed cyclization reactions of these rearrangement products are described.
ChemInform Abstract: Chiral Phosphoric Acid‐Catalyzed Asymmetric Transfer Hydrogenation of Quinolin‐3‐amines.
Authors: Cai Xian‐Feng , Guo Ran‐Ning , Feng Guang‐Shou , Wu Bo , Zhou Yong‐Gui 
Published: October 2014

AbstractA highly stereocontrolled asymmetric transfer hydrogenation of quinolin‐3‐amines is developed using Hantzsch ester in the presence of BINOL‐derived phosphoric acid catalysts.
ChemInform Abstract: AuCl3 Catalyzed [3 + 2 + 1] Cycloaddition: First Use of Aldehyde as a Carbon Monoxide‐Like One Carbon Synthon for Triple C—C Coupling.
Authors: Gayen Krishnanka S. , Maiti Dilip K. 
Published: October 2014

AbstractAu(III)‐catalyzed reaction of two equivalents of O‐propargylsalicylaldehydes with glycine esters proceeds through formation of imines and subsequent intermolecular cyclization with a second equivalent of aldehyde furnishing benzopyranopyridines (III) and (V) in good yields.
ChemInform Abstract: Transition‐Metal‐Free Cross‐Coupling Reactions by Single Electron Transfer (SET).
Authors: Sythana Suresh Kumar , Unni Santhosh , Kshirsagar Yogesh M. , Bhagat Pundlik R. 
Published: October 2014

AbstractA novel single‐step protocol for the synthesis of cinnoline derivatives by a transition‐metal‐free coupling between amino‐ and nitroaryl compounds is developed and a plausible reaction mechanism involving radical intermediates is proposed.
ChemInform Abstract: Palladium(0)‐Catalyzed Carbon—Hydrogen Bond Functionalization for the Synthesis of Indoloquinazolinones.
Authors: Tsukano Chihiro , Okuno Masataka , Nishiguchi Hiromi , Takemoto Yoshiji 
Published: October 2014

AbstractA convenient protocol is developed for the Pd‐catalyzed cyclization of substrates (I) to produce indoloquinazolines.
ChemInform Abstract: C—H Trifluoromethylations of 1,3‐Dimethyluracil and Reactivity of the Products in C—H Arylations.
Authors: Hocek Michal , Cernova Miroslava , Pohl Radek , Klepetarova Blanka 
Published: October 2014

AbstractRegioselective 5‐trifluoromethylation of 1,3‐dimethyluracil is achieved in good yield.
ChemInform Abstract: Predictably Selective (sp3)C—O Bond Formation Through Copper Catalyzed Dehydrogenative Coupling: Facile Synthesis of Dihydro‐Oxazinone Derivatives.
Authors: Modak Atanu , Dutta Uttam , Kancherla Rajesh , Maity Soham , Bhadra Mohitosh , Mobin Shaikh M. , Maiti Debabrata 
Published: October 2014

AbstractThe oxidative Cu‐catalyzed cyclization of salicylamides having two N‐alkyl substituents is developed to give dehydrooxazine derivatives in good yields.
ChemInform Abstract: Application of Cyclic Ketones in MCR: Ugi/Amide Coupling Based Synthesis of Fused Tetrazolo[1,5‐a][1,4]benzodiazepines.
Authors: Yerande Swapnil G. , Newase Kiran M. , Singh Bhawani , Boltjes Andre , Doemling Alexander 
Published: October 2014

AbstractAzido‐Ugi reaction of isonitrile, cyclic ketones, primary amines, and azide produces tetrazole derivatives.
ChemInform Abstract: Silica‐Supported Tripod Triarylphosphane: Application to Transition Metal‐Catalyzed C(sp3)—H Borylations.
Authors: Iwai Tomohiro , Murakami Ryo , Harada Tomoya , Kawamorita Soichiro , Sawamura Masaya 
Published: October 2014

AbstractThe title phosphane is used as a catalyst component for the rhodium‐ and iridium‐catalyzed C(sp3)‐H borylation of amide, urea, and alkylpyridine derivatives.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Cafestol: A Late‐Stage Construction of the Furan Ring Inspired by a Biosynthesis Strategy.
Authors: Zhu Lili , Luo Jisheng , Hong Ran 
Published: October 2014

AbstractThe ent‐kaurene derived diterpenoid (.+‐.)‐cafestol (I) exhibits anti‐inflammatory activities and a neuroprotective effect.
ChemInform Abstract: Vulgarisin A, a New Diterpenoid with a Rare 5/6/4/5 Ring Skeleton from the Chinese Medicinal Plant Prunella vulgaris
Authors: Lou Huayong , Zheng Shan , Li Tianlei , Zhang Jianxin , Fei Yue , Hao Xiaojiang , Liang Guangyi , Pan Weidong 
Published: October 2014

Abstractshows weak cytotoxicity against human lung carcinoma A549 cells
ChemInform Abstract: New Steroids with a Rearranged Skeleton as (h)P300 Inhibitors from the Sponge Theonella swinhoei.
Authors: Gong Jun , Sun Peng , Jiang Nan , Riccio Raffaele , Lauro Gianluigi , Bifulco Giuseppe , Li Tie‐Jun , Gerwick William H. , Zhang Wen 
Published: October 2014

AbstractThe sterols swinhoisterol A (I) and B (II) are isolated from the title sponge.
ChemInform Abstract: Tuning the Stereoelectronic Properties of 1‐Sulfanylhex‐1‐enitols for the Sequential Stereoselective Synthesis of 2‐Deoxy‐2‐iodo‐β‐‐allopyranosides.
Authors: Koever Andrea , Boutureira Omar , Matheu M. Isabel , Diaz Yolanda , Castillon Sergio 
Published: October 2014

AbstractThe described procedure is also performed for ribo‐configured substrates.
ChemInform Abstract: A General and Enantioselective Approach to Pentoses: A Rapid Synthesis of PSI‐6130, the Nucleoside Core of Sofosbuvir.
Authors: Peifer Manuel , Berger Raphaelle , Shurtleff Valerie W. , Conrad Jay C. , MacMillan David W. C. 
Published: October 2014

AbstractTiCl2(OiPr)2‐promoted condensation of silylketene acetals (I) and the enantioenriched aldehyde (II) produces esters of type (III) in good diastereoselectivity.
ChemInform Abstract: Neoflavonoids as Potential Osteogenic Agents from Dalbergia sissoo Heartwood
Authors: Kumar Padam , Kushwaha Priyanka , Khedgikar Vikram , Gautam Jyoti , Choudhary Dharmendra , Singh Divya , Trivedi Ritu , Maurya Rakesh 
Published: October 2014

Abstractisolation, structure and anti‐osteoporotic activity of new neoflavonoid, dalsissooal (I), along with seven known neoflavonoids
ChemInform Abstract: Rates and Energetics of Intramolecular Electron Transfer Processes in Conjugated Metallofullerenes
Authors: Schubert Christina , Rudolf Marc , Guldi Dirk M. , Takano Yuta , Mizorogi Naomi , Herranz M. Angeles , Martin Nazario , Nagase Shigeru , Akasaka Takeshi 
Published: October 2014

AbstractReview: 43 refs.
ChemInform Abstract: Palladium Catalyzed C—H Activation and Its Application to Multi‐Bond Forming Reactions
Authors: Ramachandiran Krishnan , Sreelatha Thonthula , Lakshmi Neelakandan V. , Babu Thelagathoti H. , Muralidharan Doraiswamy , Perumal Paramasiram T. 
Published: October 2014

AbstractReview: 85 refs.
Lithiummetall‐Akkumulatoren als elektrochemische Energiespeicher und die faszinierende Chemie eines ausgewählten Alkalimetalls
Authors: Hasselmann Martin , Wagner Corina , Oetken Marco 
Published: October 2014

AbstractIm Beitrag werden völlig neuartige Experimente zum Themenfeld der Lithiummetall‐Batterien und neue experimentelle Möglichkeiten zur Lithiummetallchemie in Theorie und Praxis vorgestellt. So werden u. a. eine Lithiummetall‐Batterie im Minenansatz auf Basis einer metallischen Lithium‐ und einer Anionen‐Intercalations‐Elektrode präsentiert. Die den Batteriesystemen zugrunde liegende, zentrale Idee der elektrochemischen Abscheidung von Lithium aus einer organischen, Lithiumperchlorat haltigen Elektrolytkomposition und die Intercalation von negativ geladenen Perchlorat‐Ionen in ein graphitisches Kathodenmaterial werden dabei ausführlich erläutert. Schließlich werden weitere innovative Experimente mit elektrochemisch gewonnenem Lithium vorgestellt, bspw. die Reaktion von Lithium mit Wasser, verschiedenen Alkoholen und Stickstoff.
Nucleic Acid Aptamer‐Mediated Drug Delivery for Targeted Cancer Therapy
Authors: Zhu Huijie , Li Jin , Zhang Xiao‐Bing , Ye Mao , Tan Weihong 
Published: October 2014

AbstractAptamers are emerging as promising therapeutic agents and recognition elements. In particular, cell‐SELEX (systematic evolution of ligands by exponential enrichment) allows in vitro selection of aptamers selective to whole cells without prior knowledge of the molecular signatures on the cell surface. The advantage of aptamers is their high affinitiy and binding specificity towards the target. This Minireview focuses on single‐stranded (ss) oligonucleotide (DNA or RNA)‐based aptamers as cancer therapeutics/theranostics. Specifically, aptamer–nanomaterial conjugates, aptamer–drug conjugates, targeted phototherapy and targeted biotherapy are covered in detail. In reviewing the literature, the potential of aptamers as delivery systems for therapeutic and imaging applications in cancer is clear, however, major challenges remain to be resolved, such as the poorly understood pharmacokinetics, toxicity and off‐target effects, before they can be fully exploited in a clinical setting.
Design of Highly Porous Single‐Site Catalysts through Two‐Step Postsynthetic Modification of Mixed‐Linker MIL‐53(Al)
Authors: Gotthardt Meike A. , Schoch Roland , Brunner Tobias S. , Bauer Matthias , Kleist Wolfgang 
Published: October 2014

AbstractDefined mixed‐linker metal–organic frameworks based on MIL‐53‐NH2(Al) were successfully synthesized under ambient pressure, thus, enabling easy scaling up of the synthesis. The two‐step postsynthetic modification reaction of these materials with, first, maleic anhydride and, second, palladium(II) acetate resulted in immobilized palladium(II) complexes at the side chain of the linker molecules. The high porosity of the mixed‐linker materials was retained throughout the modification process, which was in contrast to a previous study with pure MIL‐53‐NH2(Al). The novel palladium‐containing materials were applied in Heck‐type CC coupling reactions of bromo‐ or chlorobenzene with styrene, in which they exhibited high catalytic activity and selectivity.