bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors and outcomes of early coronary angiography in patients with prior coronary artery bypass surgery presenting with non-ST elevation myocardial infarction
Authors: Asrar ul Haq Muhammad , Rudd Nima , Mian Mueed , Castles Anastasia , Mogilevski Tamara , Mutha Vivek , Van Gaal William J 
Published: June 2014

IntroductionThe best strategy in patients with prior coronary artery bypass graft surgery (CABG) who present with non-ST elevation myocardial infarction (NSTEMI) remains less well defined. We compare the characteristics, therapeutic interventions and outcomes of patients with prior CABG presenting with NSTEMI.MethodsAll patients who presented to our hospital during 2007–2012 with available electronic records were analysed retrospectively. Outcomes were compared between patients who underwent coronary angiography or percutaneous coronary intervention (PCI) versus those who were treated medically.ResultsA total of 117 patients were analysed. Of that, 79 patients were managed medically while 38 underwent early angiography, of which only 11 (9.5%) received PCI. Patients treated medically (did not undergo angiography) were older (74±10 vs70±8; p=0.05). ECG changes were the only independent predictor for early angiography (OR 0.4, 95% CI 0.15 to 0.99; p=0.05) while recurrent chest pain (OR 0.2, 95% CI 0.05 to 0.97; p=0.05) predicted PCI on multivariate analysis. The PCI group had higher Global Registry of Acute Cardiac Events (GRACE) score (176±29 vs 150±31; p=0.01). No significant difference was found in readmission rates, morbidity (unstable angina pectoris, NSTEMI, ST elevation myocardial infarction (STEMI), or combination) or mortality at 12 months between the groups who underwent angiography, PCI, or treated medically on univariate and multivariate analysis.ConclusionsThe opportunity to intervene in prior CABG patients presenting with NSTEMI is often low. Initial medical management may be a reasonable option in carefully selected patients particularly in the absence of ongoing symptoms, ECG changes or very high GRACE scores. Further studies are required to evaluate the safety of non-invasive strategies in managing this population.
Interaction between access choice and pharmacotherapy for coronary intervention: the results of a UK survey
Authors: Kinnaird Tim D , Ossei-Gerning Nicholas , Mitra Rito , Anderson Richard A 
Published: June 2014

IntroductionPercutaneous coronary intervention (PCI) has changed significantly over the past decade with the uptake of radial access and the development of newer and more potent antiplatelets and safer antithrombins. This survey examined the default access route and pharmacology choice and their interaction in UK interventional practice.MethodsAn email-based survey invited interventional cardiologists to answer questions regarding arterial access and pharmacology use during PCI. Respondents were categorised into femoral, radial and radial+(if the other radial was used rather than femoral if the right radial attempt failed). Data were analysed using χ2or the Student t test.Results81% of the 204 respondents reported the radial artery as their default access site with a significant interaction between years since qualification and access choice (21.1 years for radial+vs 23 years for radial (p=0.027) vs 26.6 years for femoral (p=0.013) vs radial (p=0.0005) vs radial+). There were 19 different combinations of access and pharmacology reported. For non-ST elevation myocardial infarction PCI, there was a significant trend for radial+and radial operators to favour ticagrelor or tailored therapy versus femoral operators (54.8% vs 47.8% vs 35%, respectively, p=0.018). For primary PCI (PPCI), radial+and radial operators were much more likely to choose ticagrelor or prasugrel than femoral operators (77.2% (p<0.001) vs 73.9% (p=0.023) vs 50%, respectively (p<0.0001) for trend). For PPCI, glycoprotein inhibitor use was similar between groups (26.1% vs 25%, not significant); radial operators were much more likely to choose bivalirudin (52.8% vs 10%, p<0.0001) and much less likely to use heparin only (19.8% vs 65%, p<0.0001) than femoral operators.ConclusionsThere is a significant interaction between years since qualification and access choice. Although there is no established consensus on access site or drugs, default radial operators are significantly more likely to utilise new generation antiplatelets and bivalirudin than femoral operators.
Cardiac troponin I but not cardiac troponin T adheres to polysulfone dialyser membranes in an in vitro haemodialysis model: explanation for lower serum cTnI concentrations following dialysis
Authors: Gaze David C , Collinson Paul O 
Published: June 2014

BackgroundElevated serum cardiac troponin T (cTnT) and I (cTnI) can occur in patients with chronic kidney disease. Differences in cTn concentrations between cTnT and cTnI have been reported but the mechanism of such discrepancy has not been investigated. This study investigates the clearance of cTn with the aid of an in vitro model of haemodialysis (HD).MethodsSerum was obtained before and after a single session of dialysis from 53 patients receiving HD and assayed for cTnT and cTnI. An in vitro model of the dialysis process was used to investigate the mechanism of clearance of cTn during HD.ResultsSerum cTnI was significantly lower (p=0.043) following a session of HD whereas cTnT concentrations were similar to those obtained before HD.Using an in vitro model of dialysis, it was demonstrated that cTnI is not dialysed from the vascular compartment but adheres to the dialyser membrane.ConclusionsThe adherence of cTnI to the dialyser membrane is responsible for the observed decrease in serum cTnI following a session of dialysis. The adherence of cTnT or T-I-C complex to the dialyser membrane could not be demonstrated and supports the observation that pre-HD and post-HD serum concentrations of cTnT are similar.
The unit group of finite group algebra of a generalized dihedral group
Authors: Makhijani Neha , Sharma R. K. , Srivastava J. B. 
Published: June 2014

Let [Formula: see text] be a generalized dihedral group of order 2n and 𝔽qbe a finite field having q elements. In this note, we establish the structure of the unit group of [Formula: see text] for any odd n ≥ 3. This extends a result due to Kaur and Khan [Units in 𝔽2D2p, J. Algebra Appl. 13(2) (2014) 9pp., doi: 10.1142/S0219498813500904] as well as a result due to the authors [Units in 𝔽2kD2n, Int. J. Group Theory 3(3) (2014) 25–34].
Río de la Plata inner estuary (Argentina): main forms, sedimentary infill and Holocene evolution
Authors: Colombo Ferran , Serra Jordi , Rivero Lluis 
Published: June 2014

Abstract
The emerged part of the Río de la Plata estuary is characterized by striking coastal geomorphic features. Aerial and satellite images, field observations of the outcrops, shallow boreholes, radiometric dating of sand and shells and Ground Penetrating Radar surveys were analysed. The main sedimentary features are: a large coastal barrier (up of 220 km long), old coastal lagoons, attached beach ridge (about 210) sets distributed along 170 km, the Ibicuy sand body variously interpreted as a reworked shoal/island or delta, and cheniers. The tidal flats and the modern Paraná Delta are located in the centre and on the right side of the inner estuary. The height of the estuarine coastal barrier represents the maximum flooding surface (MFS) of the last transgression at about 6000 aBP. Other main sedimentary forms developed as a falling stage systems tract (FSST) during the sea-level drop between the aforementioned date and the present. The sea surface was about 5 m above sea-level in the inner part of the estuary during the middle-Holocene. This MFS was subsequently followed by a continuous and slow sea-level fall that controlled the generation of the large sedimentary forms developed in the innermost part of the Río de la Plata Estuary.
Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation
Authors: Lutz Eric R. , Wu Annie A. , Bigelow Elaine , Sharma Rajni , Mo Guanglan , Soares Kevin , Solt Sara , Dorman Alvin , Wamwea Anthony , Yager Allison , Laheru Daniel , Wolfgang Christopher L. , Wang Jiang , Hruban Ralph H. , Anders Robert A. , Jaffee Elizabeth M. , Zheng Lei 
Published: June 2014

AbstractPancreatic ductal adenocarcinoma (PDAC) is considered a “nonimmunogenic” neoplasm. Single-agent immunotherapies have failed to demonstrate significant clinical activity in PDAC and other “nonimmunogenic” tumors, in part due to a complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. We designed a neoadjuvant and adjuvant clinical trial comparing an irradiated, granulocyte-macrophage colony-stimulating factor (GM-CSF)–secreting, allogeneic PDAC vaccine (GVAX) given as a single agent or in combination with low-dose cyclophosphamide to deplete regulatory T cells (Treg) as a means to study how the TME is altered by immunotherapy. Examination of resected PDACs revealed the formation of vaccine-induced intratumoral tertiary lymphoid aggregates in 33 of 39 patients 2 weeks after vaccine treatment. Immunohistochemical analysis showed these aggregates to be regulatory structures of adaptive immunity. Microarray analysis of microdissected aggregates identified gene-expression signatures in five signaling pathways involved in regulating immune-cell activation and trafficking that were associated with improved postvaccination responses. A suppressed Treg pathway and an enhanced Th17 pathway within these aggregates were associated with improved survival, enhanced postvaccination mesothelin-specific T-cell responses, and increased intratumoral Teff:Treg ratios. This study provides the first example of immune-based therapy converting a “nonimmunogenic” neoplasm into an “immunogenic” neoplasm by inducing infiltration of T cells and development of tertiary lymphoid structures in the TME. Post-GVAX T-cell infiltration and aggregate formation resulted in the upregulation of immunosuppressive regulatory mechanisms, including the PD-1–PD-L1 pathway, suggesting that patients with vaccine-primed PDAC may be better candidates than vaccine-naïve patients for immune checkpoint and other immunomodulatory therapies. Cancer Immunol Res; 2(7); 616–31. ©2014 AACR.
Multivariate Regression Reconstruction and Its Sampling Error for the Quasi-Global Annual Precipitation from 1900 to 2011
Authors: Shen Samuel S. P. , Tafolla Nancy , Smith Thomas M. , Arkin Phillip A. 
Published: June 2014

Abstract
This paper provides a multivariate regression method to estimate the sampling errors of the annual quasi-global (75°S–75°N) precipitation reconstructed by an empirical orthogonal function (EOF) expansion. The Global Precipitation Climatology Project (GPCP) precipitation data from 1979 to 2008 are used to calculate the EOFs. The Global Historical Climatology Network (GHCN) gridded data (1900–2011) are used to calculate the regression coefficients for reconstructions. The sampling errors of the reconstruction are analyzed in detail for different EOF modes. The reconstructed time series of the global-average annual precipitation shows a 0.024 mm day−1 (100 yr)−1 trend, which is very close to the trend derived from the mean of 25 models of phase 5 of the Coupled Model Intercomparison Project. Reconstruction examples of 1983 El Niño precipitation and 1917 La Niña precipitation demonstrate that the El Niño and La Niña precipitation patterns are well reflected in the first two EOFs. Although the validation in the GPCP period shows remarkable skill at predicting oceanic precipitation from land stations, the error pattern analysis through comparison between reconstruction and GHCN suggests the critical importance of improving oceanic measurement of precipitation.
Verification of Quantitative Precipitation Reforecasts over the Southeastern United States
Authors: Baxter Martin A. , Lackmann Gary M. , Mahoney Kelly M. , Workoff Thomas E. , Hamill Thomas M. 
Published: June 2014

Abstract
NOAA’s second-generation reforecasts are approximately consistent with the operational version of the 2012 NOAA Global Ensemble Forecast System (GEFS). The reforecasts allow verification to be performed across a multidecadal time period using a static model, in contrast to verifications performed using an ever-evolving operational modeling system. This contribution examines three commonly used verification metrics for reforecasts of precipitation over the southeastern United States: equitable threat score, bias, and ranked probability skill score. Analysis of the verification metrics highlights the variation in the ability of the GEFS to predict precipitation across amount, season, forecast lead time, and location. Beyond day 5.5, there is little useful skill in quantitative precipitation forecasts (QPFs) or probabilistic QPFs. For lighter precipitation thresholds [e.g., 5 and 10 mm (24 h)−1], use of the ensemble mean adds about 10% to the forecast skill over the deterministic control. QPFs have increased in accuracy from 1985 to 2013, likely due to improvements in observations. Results of this investigation are a first step toward using the reforecast database to distinguish weather regimes that the GEFS typically predicts well from those regimes that the GEFS typically predicts poorly.
Prediction of Hearing Outcomes by Multiple Regression Analysis in Patients With Idiopathic Sudden Sensorineural Hearing Loss
Authors: Suzuki Hideaki , Tabata Takahisa , Koizumi Hiroki , Hohchi Nobusuke , Takeuchi Shoko , Kitamura Takuro , Fujino Yoshihisa , Ohbuchi Toyoaki 
Published: June 2014

Objective: This study aimed to create a multiple regression model for predicting hearing outcomes of idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: The participants were 205 consecutive patients (205 ears) with ISSNHL (hearing level ≥ 40 dB, interval between onset and treatment ≤ 30 days). They received systemic steroid administration combined with intratympanic steroid injection. Data were examined by simple and multiple regression analyses. Three hearing indices (percentage hearing improvement, hearing gain, and posttreatment hearing level [HLpost]) and 7 prognostic factors (age, days from onset to treatment, initial hearing level, initial hearing level at low frequencies, initial hearing level at high frequencies, presence of vertigo, and contralateral hearing level) were included in the multiple regression analysis as dependent and explanatory variables, respectively. Results: In the simple regression analysis, the percentage hearing improvement, hearing gain, and HLpost showed significant correlation with 2, 5, and 6 of the 7 prognostic factors, respectively. The multiple correlation coefficients were 0.396, 0.503, and 0.714 for the percentage hearing improvement, hearing gain, and HLpost, respectively. Predicted values of HLpost calculated by the multiple regression equation were reliable with 70% probability with a 40-dB-width prediction interval. Conclusion: Prediction of HLpost by the multiple regression model may be useful to estimate the hearing prognosis of ISSNHL.
Complications After Tracheal and Cricotracheal Resection and Anastomosis for Inflammatory and Neoplastic Stenoses
Authors: Piazza Cesare , Del Bon Francesca , Paderno Alberto , Grazioli Paola , Mangili Stefano , Lombardi Davide , Nicolai Piero , Peretti Giorgio 
Published: June 2014

Objective: This study aimed to evaluate complications and success rates of tracheal resection and anastomosis (TRA) and cricotracheal resection and anastomosis (CTRA) in patients treated in 2 academic institutions. Methods: Retrospective charts review of 137 patients submitted to TRA/CTRA. Fifty (36.5%) had neoplastic (group A) and 87 (63.5%) benign (group B) stenoses. Using univariate analysis, age, medical comorbidities, previous radiotherapy, type of TRA/CTRA, association with neck dissection and thyroidectomy, length of resected airway, and preoperative tracheotomy were evaluated to identify factors predictive of complications and outcomes. Results: The mean length of resected airway was 2.7 and 3 cm in groups A and B, respectively. Overall decannulation and complication rates for group A were 96% and 36%, and 99% and 46% for group B, respectively. Length of airway resected and presence of preoperative tracheotomy had a statistically significant effect on major surgical complications. Age older than 70 and cardiovascular and pulmonary comorbidities were significantly associated with the incidence of major medical complications. No statistically significant difference was found considering the complication rates of group A versus group B. Conclusion: Even though the overall success rate of TRA/CTRA is high, it should always be regarded as a major surgical procedure with a non-negligible incidence of complications.
Overview of the in vitro stability of commonly measured vitamins and carotenoids in whole blood
Authors: Cuerq Charlotte , Peretti Noël , Chikh Karim , Mialon Anne , Guillaumont Marc , Drai Jocelyne , Blond Emilie 
Published: June 2014

Background The pre-analytical stabilities of vitamins A, E, K, B1, B2, B6, B12, C, carotenoids and folates in whole blood were studied. The aim of this work was to provide clear and workable pre-analytical procedures specifying optimal delay before freezing for laboratories which perform themselves such analyses or which receive and transfer such specimens to referral laboratories. Methods The stability of vitamins was studied in whole blood at room temperature after light exposure up to 24 h (vitamin C), 48 h (vitamins A, E, B1, B2, B6 and carotenoids) and 72 h (vitamins K, B12, red blood cell (RBC) and serum folates). Vitamin C stability after baseline acidification was analysed up to 48 h. Changes observed were compared to a clinical cut-off defined as total change limit based on a combination of analytical performance and within-subject variation. Results Clinically and statistically significant changes occurred only in vitamins C (−22.5%), B6 (+9.9%) and serum folates (−16.8%) concentrations after 6, 24 and 48 h, respectively. Vitamins A, E, K, B1, B2, B12, RBC folates and carotenoids showed good stability up to 48 or 72 h. Vitamin C in acidified serum conserved at room temperature appeared unstable. The optimal condition for acidified vitamin C conservation was at less than −20℃. Conclusion The majority of vitamins remain stable for up to 48 h. Vitamin C quantification requires serum acidification followed by freezing as soon as possible. Freezing, respectively, within 12 h and 24 h for determination of plasma vitamin B6 and serum folates concentrations is recommended.
Thinking Aloud Influences Perceived Time
Authors: Hertzum Morten , Holmegaard Kristin Due 
Published: June 2014

Objective: We investigate whether thinking aloud influences perceived time. Background: Thinking aloud is widely used in usability evaluation, yet it is debated whether thinking aloud influences thought and behavior. If thinking aloud is restricted to the verbalization of information to which a person is already attending, there is evidence that thinking aloud does not influence thought and behavior. Method: In an experiment, 16 thinking-aloud participants and 16 control participants solved a code-breaking task 24 times each. Participants estimated task duration. The 24 trials involved two levels of time constraint (timed, untimed) and resulted in two levels of success (solved, unsolved). Results: The ratio of perceived time to clock time was lower for thinking-aloud than control participants. Participants overestimated time by an average of 47% (thinking aloud) and 94% (control). The effect of thinking aloud on time perception also held separately for timed, untimed, solved, and unsolved trials. Conclusion: Thinking aloud (verbalization at Levels 1 and 2) influences perceived time. Possible explanations of this effect include that thinking aloud may require attention, cause a processing shift that overshadows the perception of time, or increase mental workload. Application: For usability evaluation, this study implies that time estimates made while thinking aloud cannot be compared with time estimates made while not thinking aloud, that ratings of systems experienced while thinking aloud may be inaccurate (because the experience of time influences other experiences), and that it may therefore be considered to replace concurrent thinking aloud with retrospective thinking aloud when evaluations involve time estimation.
Thoracoscopic wedge lung resection using virtual-assisted lung mapping
Authors: Sato Masaaki , Aoyama Akihiro , Yamada Tetsu , Menjyu Toshi , Chen Fengshi , Sato Toshihiko , Sonobe Makoto , Omasa Mitsugu , Date Hiroshi 
Published: June 2014

Background Virtual-assisted lung mapping is a novel bronchoscopic preoperative lung marking technique using virtual images to conduct multiple concurrent lung markings with dye. This study analyzed the indications, mapping design, and outcomes of lung wedge resection using virtual-assisted lung mapping. Methods From August 2012 to October 2013, 35 patients with 59 lesions were planned to undergo thoracoscopic lung wedge resection aided by virtual-assisted lung mapping. The data related to virtual-assisted lung mapping were prospectively collected, with the exception of the mapping design which was retrospectively analyzed. Results Suspected primary lung cancer (21 lesions in 18 patients) and metastatic lung tumors (38 lesions in 17 patients) were treated by thoracoscopic lung wedge resection with the aid of virtual-assisted lung mapping; 50 wedge resections were conducted with 107 markings. Virtual-assisted lung mapping was most frequently designed to place 2 ( n = 15 wedge resections) or 3 ( n = 17) markings to both identify the tumor(s) and secure a sufficient resection margin. In 7 wedge resections, anatomical landmarks and/or imaginary auxiliary lines functioned as complementary parts of the lung map when bronchial anatomy did not allow for markings at ideal spots. The resection outcomes were satisfactory without clinically evident complications. Conclusion Multiple markings of virtual-assisted lung mapping not only enabled tumor identification, but also secured sufficient resection margins. Special techniques using anatomical landmarks and imaginary auxiliary lines were complementary to the lung map when bronchial anatomy did not allow for markings at ideal spots.