bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening Piety
Authors: de Bruijn Petra 
Published: August 2024

Abstract
In the 20th century, Turkish film and television series became important mediators of societal and moral messages, mirroring Turkish sociopolitical developments regarding religion. This chapter provides a chronological overview of the depiction of religion—mainly Islam, but also other religions as well as secularism—in film and television series. It demonstrates how reflecting on religion in the Kemalist era until 1950 was mostly negative. Films about Islamic topics started to be produced when Islam slowly resurged in public life during the multiparty period. While television was under state control until the 1990s, representing religious issues was difficult. Most series provided a neutral position toward religion by not reflecting on it, and religious identifiers were scarce. Private broadcasting diversified the media landscape during the 1990s, and television series reflecting an Islamic worldview occurred. The emergence of international video-on-demand platforms provided opportunities for exploring sensitive themes such as the divide between Islamic and secular in Turkish society and the injustices done to Jews and Christians.
Agent-Based Modelling and Social Network Analysis
Authors: Campos Pedro 
Published: August 2024

Abstract
Social network analysis offers a powerful method for comprehending intricate systems created through agent-based computational models. Scholars contend that intricate agent networks have the capacity to grasp both the dynamics at an individual level and the overarching characteristics at a global level within a complex system. Consequently, they can contribute to a deeper comprehension of the underlying principles governing such systems. Within this endeavour, we undertake a comprehensive examination of the existing body of literature that establishes a connection between agent-based models and social network analysis. The focal aim of this exploration is to cater to the domain of management studies. We define a baseline for a network topology for a taxonomy of ‘macro’ and ‘micro’ characteristics of social interaction networks. We apply and extend this taxonomy for agent-based models and classify existing models in macro structures, macro patterns of interaction, micro interactions and multilayers, and micro level (clustering and local interaction). We also emphasize the learning methods for agent-based models of social networks.
Agent-Based Models as Digital Twins in Management Science
Authors: Mäs Michael 
Published: August 2024

Abstract
Leveraging advancements in data science, computational capabilities, and artificial intelligence, researchers are constructing so-called digital twins of complex systems as diverse as space vehicles, cars, supply chains, individual patients, power plants, and cities. These digital models, characterized by their high fidelity and grounded in large amounts of frequently updated empirical data, serve as potent instruments for predicting the dynamic behaviours of these complex systems. What is more, they facilitate experimentation with counterfactual scenarios, allowing to compare digital twins with counterfactual siblings. These experiments enable modellers to address research problems that would otherwise remain unanswered due to the unavailability of empirical data, often for practical or ethical considerations. This chapter scrutinizes the challenges associated with crafting digital twins of complex organizations, contending that both technical and ethical hurdles demand careful consideration. While digital twins serve as tools to enhance organizational performance for all stakeholders, they also harbour the potential to be leveraged in ways that may run counter to the interests of certain members within the organization. This chapter posits that the evaluation and potential resolution of these challenges present formidable research opportunities for organizational modellers, underscoring these obstacles as not only impediments but also as intriguing research problems to be addressed.
Principles of Social Cognition
Authors: Carlston Donal E. , Hugenberg Kurt , Johnson Kerri L. 
Published: August 2024

Abstract
This chapter describes how the cognitive revolution led to the emergence of social cognition, which has been defined in terms of five basic principles embodying emphases on cognitivism, information processing, process, generality/universality, and social issues. Each of these principles is discussed in term of its background, its influence, and its current status. The chapter concludes that, with modest alterations, these principles remain important in the early twenty-first century, both within social cognition and within the broader field of social psychology. However, the chapter also suggests that contemporary social cognition differs from its original conception. So, though social cognition lives on, and is more influential than ever, it is not the same social cognition that emerged in the 1970s.
Motivation and Performance
Authors: Miele David B. , Scholer Abigail A. , Higgins E. Tory 
Published: August 2024

Abstract
Motivation researchers within the field of social cognition often examine types of motivation that are thought to be qualitatively distinct (e.g., autonomous vs. controlled regulation, promotion vs. prevention focus, and locomotion vs. assessment orientation). Research suggests that the benefits of one type of motivation relative to another depend on the demands of the task and the context in which it is situated (termed task–motivation fit). However, there is yet to be a detailed account of what makes a particular type of motivation qualitatively distinct from other types of motivation or to explain whether these different motivations are always mutually exclusive. To address these issues and to explore the psychological mechanisms that may underlie task–motivation fit, this chapter outlines a speculative framework for investigating motivational trade-offs that draws on concepts from dynamic systems theory. It also explores the implications of this framework for research on metamotivational self-regulation.
Social Cognition and Access to Justice
Authors: Quintanilla Victor D. 
Published: August 2024

Abstract
While the promise of equal justice for all is lauded, the reality of the American civil justice system falls far short of this ideal. For most low-income and many middle-income people, the inability to secure representation renders our civil justice system inaccessible and, at worst, oppressive. This chapter speaks to how research on social cognition can be harnessed to promote access to justice and explores the theory that legal professionals in the American civil justice system unreflectively engage in a social categorization process in which they socially construct unrepresented persons into pro se parties. This chapter discusses how judges and lawyers do unrepresented status by imputing stereotypes, schemas, biases, expectancies, and labels about pro se parties onto unrepresented persons who encounter the civil justice system. The chapter emphasizes understanding this process of social construction taking place in interactions among judges, lawyers, and unrepresented persons within the civil justice system.
Abstract 1: A Brand-New Sourcing to Maximize Ethnic Diversity in Neonatal Stem Cell Collections and Correlated HLA Deep Understanding. Both to Improve Unrelated Cord Blood Units Inventory Efficiency and Biodata Based Drug Research
Authors: Nouzies Didier 
Published: August 2024

Abstract

Introduction
AfricaCord© by CORDSAVINGS Switzerland, is an initiative to secure genetic diversity for neonatal stem-cell therapeutics and research aiming to be an actual reservoir for cell therapies and a cutting-edge BIO+DATA support for new drug discovery.
A Swiss-Kenya unique private-public partnership consisting first to harvest cord blood and neonatal tissues units in public hospital on Kenyan side then to have them sent, processed then stored at CORDSAVINGS Swiss laboratory.

Objectives
(1) Therapeutic:
- at worldwide scale, improve public cbu repositories efficiency in particular among ethnic minorities thanks to a virgin source of HLA polymorphisms coming from cradle of humankind
- at African scale, to target sickle cell anemia and newborn morbidity
NGS sequencing of both of mother and newborn will allow systematic NIMA analysis to improve cbu stock release rates.
(2) Research:
again thanks to mother+newborn NGS, reveal genes variants that contribute to diseases and still not found in previous caucasian-origin-centric studies (infectious diseases in particular, as specific homozygous HLA alleles combinations are known as associated with certain protections or susceptibility).

Results
Methods & Results:
- in 2023, after signing MoU with targeted Kenyan county and got set of authorizations at local and national level, we conducted a bio-logistic oriented feasibility study in order to prove first that whole chain can work from local biocollection to storage in Switzerland while fulfilling satisfactory medico-technical criteria
- next stage: a 1’500 “Therapeutic-grade” cbu collection (additional 2’000 “R&D-high-grade” samples) to be sent to Switzerland for process and storage
- Joint-Venture with Kenyan public authorities for having a complementary laboratory locally
- optionally, to handle part of brand-new public hospital of the county to establish a Pan-African expertise center in SC therapies for newborns and SCA along with top-range HLA-centric R&D specialty

Discussion
Cbu based HSC therapies, currently at its worrisome bottom, hopefully to be revitalized by AfricaCord©.
Regarding research, academic interest should be high (SC oriented clinical trials, population genetics departments etc.).
To lead to cooperations with biotech-pharma seeking for straightforward and regular tools flow to improve their knowledge of genomic determinants of health and thus facilitate their drug discovery and translational research.
Abstract 4: Cord Blood Unit: Many Treatment Opportunities for Many Patients
Authors: Tancredi Giuseppa , Migliore Massimiliano , Amorini Maria , Lucia Anna Di , Giarratana Rosamaria , Rizzuto Luigi , Gallerano Pasquale 
Published: August 2024

Abstract

Introduction
The Sicily Cord Blood Bank (Italy) is connected to 43 birth centers that collect cord blood unit (SCO) for solidarity purposes.
95% of SCO units collected and not suitable for transplant use (HSC &lt; 2 x 106 and TNC &lt; 1200 x 106) can be recovered with the production of erythrocytes from leucodepleted cord blood (CB-RBC), platelets-poor plasma (CB-PPP) and platelet-rich plasma (CB-PC) usable for clinical use.

Objectives
Cord Blood units can be used for different applications to care many patients and to explore new lines of research.

Methods
SCO units suitable for clinical use with a volume &gt; 40 ml and platelet &gt; 150 x 109/L were subjected to fractionation using validated method and locally available equipment and commercial BioNest ABC and EF medical devices.
SCO units were double centrifuged to obtain CB-PC, CB-PPP and CB-RBC.
CB-RBCs were diluted with saline-adenine-glucose-mannitol (SAG-M) solution, leucodepleted by filtration and stored at 2-6°C.
The CB-RBC units produced have a hemolysis rate of 0.35% in 96.6% units, an average volume of 54.63 ml, an average HT of 57.7%, a count of total residual WBC &lt; 1 x 106 for unit in the 98.9% of total units.

Results
In 2022-2023, a total of 3270 SCO units were withdrawn from 43 birth centers.
98 units were cryopreserved and made available for transplant purposes.
A total of 230 CB-RBC units (7%), 1829 CB-PC units and 1829 CB-PPP units useful for clinical use (production of eye drops, platelet gel and transfusion in premature newborns) were produced.

Discussion
The benefits of treatment with blood components for non trasfusion and trasfusion use with Cord Blood Unit collected are now known and consolidated in the scientific litterature for many therapeutic indications. For extensive use, it is desirable to undertake an intensive collection program in all birth centers to include new units in the inventories with a high number of HSCs and TNCs useful for transplantation and blood components for non-transfusion and transfusion use for the benefit of patients and with economic return to support the costs of the Cord Blood Banks.
Abstract 7: Influence of Long-term Storage of Cryopreserved Automated Volume-Reduced Cord Blood Units Until 20 Years: Analysis From Barcelona Cord Blood Bank, Spain.
Authors: Castillo Nerea , Azqueta Carmen , Valdivia Elena , Garcia-Buendia Ana , Maroto Jesus , Martorell Lluis , Farssac Elisenda , Rubio Nuria , Querol Sergio , Fernandez-Sojo Jesus 
Published: August 2024

Abstract

Introduction
Barcelona Cord Blood Bank (BCBB) program started for CB units (CBU) donations in 1991. In 2002, Automated Volume-Reduced method was introduced applying the closed System (Sepax®, Cytiva). In order to ensure the quality of cryopreserved units after long-term storage, CBB programs evaluate cell recovery, progenitor cells functionality such as viability and Colony forming unit (CFU), and myeloid recovery after cord blood transplant (CBT).

Objectives
This retrospective study investigated quality parameters of CBUs stored for 1-20 years processed by automated volume-reduced and cryopreserved and stored in Bioarchive® system, (Thermogenesis) showing the effect of cryopreservation on variables measured both pre- and post-thaw. Additionally, we analyzed engraftment after CBT transplantation according to CBU time storage.

Methods
CBUs used for transplantation between2002 to 2022 were included in the study. To evaluate the influence of long-term storage of cryopreserved CBUs, Kruskal-Wallis correlation test between quality variables was performed. We studied correlation between pre-cryopreservation and post-thaw values (recovery) of TNC and CD34+ counts, CD45+ and CD34+ viability, CFU and CFU-FM counts. Additionally, myeloid engraftment was evaluated categorizing whole population in 3 groups according CBU storage duration: short-term (≤ 2 years), medium-term (&gt; 2 and ≤ 5 years) and long-term (&gt; 5 years).

Results
A total of 1577 CBUs with a median of 3.9 (range 1.3-20 years) of cryopreservation storage were evaluated. The median of TNC and CD34+ recovery, CD45+ and CD34+ recovery, CFU and CFU-GM recovery were 81.7%, 79.9%, 54.4%, 73.3%, 58.2% and 26.5%, respectively. Analysis demonstrated a non-significance decreased in CD34+ counts recovery, infused CD34 + 7AAD-viability and CFU-GM counts (P = 0.12, P = 0.28 and P = 0.96, Figure 1), respectively. Neutrophil engraftment at 42 days after CBT was found significantly faster for short-term stored CBUs (98%; CI95%, 96-99%, P = 0.015, Figure 1). No significance difference was found in platelet engraftment at 60 days between CBUs storage time groups (P = 0.5).

Discussion
Most quality parameters results evaluating CBUs demonstrated no significance decrease up to 20 years of cryopreservation meaning likely successful clinical transplantation of CBUs following long-term storage. Long-term cryopreserved CBUs continue to fulfil release FACT-Netcord requirements.
Abstract 10: Effect of Human Fetal Hemoglobin on Reactive Oxygen Species in DMSO Cryopreserved Cord Blood Progenitors Post Thaw
Authors: Zeeshan Waleed , Akabutu Heather , Akabutu John 
Published: August 2024

Abstract

Introduction
Cord blood processing and cryopreservation have emerged as pivotal techniques in regenerative medicine, facilitating the extraction and long-term preservation of stem cells for therapeutic applications. Maximizing cell viability and count post-rejuvenation is paramount for the success of cryopreserved cell-based therapies. However, challenges persist in achieving optimal rejuvenation of cryopreserved cells, necessitating innovative approaches.

Objectives
In this study, we investigated the potential of Human Fetal Hemoglobin (HFH) supplementation to enhance the rejuvenation of cryopreserved cells post thaw. Utilizing the CCBR’s double centrifugation technique, cord blood samples were processed to extract stem cells and leukocytes. Subsequently, samples were cryopreserved after the addition of DMSO and divided into experimental groups supplemented with HFH and control groups. Flow cytometry was employed to assess cell viability and counts, focusing on leukocytes (LC) and CD34-marked stem cells.

Methods
The Moxiflow cytometer was utilized for cell counting per the Coulter principle. We determined viability using propidium iodide staining. Biolegend anti-human CD34 antibody clone 581 was used for CD34 count.

Results
Preliminary findings suggest a notable increase in cell viability and count in HFH-supplemented samples compared to controls. In one sample, we observed 3.08x10^6 cells/mL CD34 (Viability 99.8%), 8.03x10^6 cells/mL LC count (Viability 100%) in HFH-supplemented samples, compared to 1.61x10^4 cells/mL CD34 (Viability 100%), 3.68x10^5 cells/mL LC count (Viability 100%) in controls. Similar results were observed in an additional sample. These results indicate the potential of HFH supplementation in augmenting the rejuvenation of cryopreserved cells, thus improving the efficacy of cell-based therapies.

Discussion
We hypothesize that HFH exerts its effects by mitigating oxygen radical-induced cell damage, thereby facilitating glucose uptake for enhanced glycolysis and ATP production. We believe the robust glycolytic activity triggers the activation of proliferating pathways in the mitochondria, generating additional ATP. Concurrently, reactive oxygen radicals produced during this process are potentially quenched by the presence of HFH, ensuring cellular integrity and function.
These preliminary findings underscore the significance of HFH supplementation as a promising strategy to enhance the effectiveness of cryopreserved cell-based therapies. Further investigation into the underlying mechanisms and clinical validation of this approach are warranted to fully exploit its therapeutic potential and translate it into clinical practice.

Moxiflow Results
Abstract 16: Tissue Engineering Approach Using Heterogeneous Hydrogel Combined with Umbilical Cord Derived Multipotent Stem Cells for the Consequences Military Spinal Cord Injury Neurosurgical Treatment (Case Report)
Authors: Petriv Taras , Rybachuk Oksana , Vorodi Milan , Zarovna Halyna , Luzan Boris , Medvediev Volodymyr , Tsymbaliuk Vitaliy 
Published: August 2024

Abstract

Introduction
Military spinal cord injury is a severe injury, accompanied by high mortality and profound disability. Such injuries are usually penetrating, complex, infected, require intensive treatment at the initial stages and complex reconstructive neurosurgical interventions at later stages. This problem is especially relevant for Ukraine now, during the russian attack.

Objectives
The objective of the study was to investigate the short-term effect and safety of tissue engineering approach using umbilical cord arteries derived multipotent stem cells (UCA-MSCs) and heterogenous hydrogel for the consequences of military spinal cord injury neurosurgical treatment.

Methods
Patient B, the soldier of the National Guard of Ukraine, born on 1984, was wounded on 07/27/22 during a battle near Bakhmut. At 07/28/22 spinal cord decompression and fixation surgery was performed at the lower thoracic level (Th10). The patient had lower paraplegia (ASIA A), and neurogenic bladder. Complete anatomical and functional spinal cord transection below the Th10 level was confirmed. The patient was offered treatment in the frame of a research program "To investigate the effectiveness of regenerative cell technologies in the neurosurgical treatment of patients with demyelinating diseases of the CNS and cerebral palsy. № 0119U000112". UCA-MSCs for this case were isolated from a healthy human umbilical cord and had characteristics according to the minimal criteria of MSC. The hydrogel (poly[N-(2-hydroxypropyl)-methacrylamide]) is a commercial preparation synthesized in the laboratory of E. Pinet (FISO Technologies Inc., Quebec, Canada) by heterogeneous polymerization and association. 12/06/23 operation was performed: myeloradiculolysis, excision of areas of the glial scar of the spinal cord and filling of the defect with a heterogeneous hydrogel combined with UCA-MSCs.

Results
On the 6th months of observation, the patient has no infectious and inflammatory complications, and elements of deep sensitivity appeared in the proximal areas of the buttocks. No adverse effects during the observation period were recorded.

Discussion
More cases are needed to determine this method's safety and effectiveness, but early results are promising. A careful selection of patients is necessary for the use of this method, namely: confidence in the complete anatomical and functional transection of the spinal cord and the patient's informed consent for treatment.
Genomic correlates of the response to first-line PD-1 blockade plus chemotherapy in patients with advanced non-small-cell lung cancer
Authors: Jiang Tao , Chen Jian , Wang Haowei , Wu Fengying , Chen Xiaoxia , Su Chunxia , Zhang Haiping , Zhou Fei , Yang Ying , Zhang Jiao , Sun Huaibo , Zhang Henghui , Zhou Caicun , Ren Shengxiang 
Published: August 2024

Abstract

Background:
Programmed death 1 (PD-1) blockade plus chemotherapy has become the new first-line standard of care for patients with advanced non-small-cell lung cancer (NSCLC). Yet not all NSCLC patients benefit from this regimen. This study aimed to investigate the predictors of PD-1 blockade plus chemotherapy in untreated advanced NSCLC.

Methods:
We integrated clinical, genomic, and survival data from 287 patients with untreated advanced NSCLC who were enrolled in one of five registered phase 3 trials and received PD-1 blockade plus chemotherapy or chemotherapy alone. We randomly assigned these patients into a discovery cohort (n = 125), a validation cohort (n = 82), and a control cohort (n = 80). The candidate genes that could predict the response to PD-1 blockade plus chemotherapy were identified using data from the discovery cohort and their predictive values were then evaluated in the three cohorts. Immune deconvolution was conducted using transcriptome data of 1014 NSCLC patients from The Cancer Genome Atlas dataset.

Results:
A genomic variation signature, in which one or more of the 15 candidate genes were altered, was correlated with significantly inferior response rates and survival outcomes in patients treated with first-line PD-1 blockade plus chemotherapy in both discovery and validation cohorts. Its predictive value held in multivariate analyses when adjusted for baseline parameters, programmed cell death ligand 1 (PD-L1) expression level, and tumor mutation burden. Moreover, applying both the 15-gene panel and PD-L1 expression level produced better performance than either alone in predicting benefit from this treatment combination. Immune landscape analyses revealed that tumors with one or more variation in the 15-gene panel were associated with few immune infiltrates, indicating an immune-desert tumor microenvironment.

Conclusion:
These findings indicate that a 15-gene panel can serve as a negative prediction biomarker for first-line PD-1 blockade plus chemotherapy in patients with advanced NSCLC.