bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alliaceous Migraines
Authors: Roussos Alexander P. , Hirsch Alan R. 
Published: April 2013

ObjectiveTo report a migraineur with osmophobia and trigger to garlic and onion aroma.BackgroundWhile odors serve as a trigger in 70% of migraineurs, alliaceous aromas have been described only rarely. Furthermore, nor has more than one type of alliaceous odor acted as a trigger in the same individual. Neither has migraine with aura been described as precipitated by such aromas. A patient experiencing migraines with aura, triggered almost exclusively by alliaceous aromas, is described.MethodsCase study: 32‐year‐old woman; 5 years previously felt nasal pruritis upon eating a red onion dip. Shortly thereafter, the mere aroma of raw onions caused a sensation of her throat closing along with an associated panic attack. Over the intervening years, upon exposure to onions and garlic aroma she experienced a fortification spectra and visual entopia, followed by a bipareital, crushing level 10/10 headache, burning eyes and nose, lacrimation, perioral paresthesias, generalized pruritis, nausea, fatigue, sore throat, dysarthria, confusion, dyspnea, palpitations, presyncopal sensations, hand spasms, tongue soreness, neck pain, phonophobia, and photophobia. These would persist for 1 hour after leaving the aroma. She was unresponsive to medication and would wear a surgical mask when out. The patient also experienced chemosensory complaints: dysosmias every few months; phantosmias of food or cleaning products every month for a minute of level 5/10 intensity; pallinosmia of onion or garlic odor for 30 minutes after exposure; and metallic pallinugeusia after eating with metal utensils.ResultsNeurological exam normal except for bilateral positive Hoffman reflexes.Chemosensory TestingQuick Smell Identification Test 3/3 and Brief Smell Identification Test 12/12 were normal. Magnetic resonance imaging and computed tomography with and without contrast normal. Allergy skin test was positive for garlic and onion. Nose plug and counter stimulation with peppermint prevented the onset of headaches and associated symptoms.ConclusionThis is the first report of migraines with aura triggered by more than one alliaceous compound in the same individual. Possible mechanisms include odor induced, emotional change, vasomotor instability, trigeminal‐induced neurogenic inflammation, and allergic response. In alliaceous and odor‐induced migraines, a trial of counter stimulation and nose plugs is warranted.
Interleukin‐17‐producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor
Authors: Chen Wen‐Chung , Lai Yu‐Hsuan , Chen Hung‐Yu , Guo How‐Ran , Su Ih‐Jen , Chen Helen H W 
Published: April 2013

AimsInterleukin‐17 (IL‐17) is a proinflammatory cytokine that is most prominently produced by T‐helper type 17 (Th17) cells, a distinct CD4+ T‐helper cell subset. The aim of this study was to investigate the level of IL‐17‐producing cells in the breast cancer tumour microenvironment and its prognostic role.Methods and resultsA total of 207 breast carcinoma specimens were assessed by IL‐17 immunohistochemistry, and the findings were correlated with clinicopathological parameters. We found that increased numbers of IL‐17‐producing cells were correlated with high histological grade, negative ER/PR status, and triple‐negative molecular subtypes segregated by immunoprofiles. However, they did not correlate with stage, tumour size, nodal status, HER2 status, or histological type. Patients with tumours with high numbers of IL‐17‐producing cells had shorter disease‐free survival (DFS) than patients with tumours with low numbers of IL‐17‐producing cells (P < 0.01). In multivariate analysis, high IL‐17 level [hazard ratio (HR) 2.24; 95% CI 1.06–4.75], advanced T stage (HR 2.73; 95% CI 1.30–5.73), positive HER2 status (HR 4.88; 95% CI 1.47–16.18) and triple‐negative subtype (HR 7.46; 95% CI 1.38–40.36) were significant prognostic factors for DFS.ConclusionsOur results indicate that a high level of IL‐17‐producing cells in the breast cancer tumour microenvironment is a poor prognostic factor.
pPKC α regulates through integrin β 1 human gingival fibroblasts/Streptococcus mitis adhesion in response to HEMA
Authors: di Giacomo V. , Pacella S. , Rapino M. , Di Giulio M. , Zara S. , Pasquantonio G. , Cellini L. , Cataldi A. 
Published: April 2013

AbstractAimTo investigate in coculture of human gingival fibroblasts (HGFs) and Streptococcus mitis, the molecular mechanisms driving the response to 2‐hydroxyethyl methacrylate (HEMA) in terms of eukaryotic/prokaryotic cell adhesion, signal transduction and apoptosis.MethodologyThe clinical strain S. mitis DS12, cultured in Trypticase soy broth was added to HGFs, obtained from fragments of healthy marginal gingival tissue and cultured in DMEM, treated with 3 mmol L−1 2‐hydroxyethyl methacrylate (HEMA) for 48 h and processed for microscopic, western blotting and flow cytometric analyses.Results2‐hydroxyethyl methacrylate (HEMA) treatment increased the adhesion between S. mitis and HGFs, which seemed to be mediated by the PKC α/integrin β 1 signalling system, improved by the presence of saliva. It also reduced the viability and the adhesion of HGFs to polypropylene substrate in terms of procollagen I and MMP3 expression. The presence of saliva and S. mitis reduced the number of necrotic HGFs and upregulated the expression of both procollagen I and MMP3.ConclusionsThese results shed more light on the biological and molecular events occurring in vitro in a coculture model that mimics the environment of the oral cavity with HEMA treatment. The key role played by oral bacteria and saliva in preventing inflammatory and toxic processes that occur in vivo in human gingival fibroblasts upon the release of dental material monomers is confirmed.
Epithelioid angiomyolipoma of the kidney: Radiological imaging
Authors: Tsukada Jitsuro , Jinzaki Masahiro , Yao Masahiro , Nagashima Yoji , Mikami Shuji , Yashiro Hideki , Nozaki Miwako , Mizuno Ryuichi , Oya Mototsugu , Kuribayashi Sachio 
Published: April 2013

ObjectivesTo review the imaging findings of renal epithelioid angiomyolipomas.MethodsEight patients treated at two institutions were pathologically diagnosed as having epithelioid angiomyolipoma. All of them underwent computed tomography, and four underwent magnetic resonance imaging. The tumor size, existence of fat, heterogeneity, computed tomography attenuation, degree of enhancement, enhancement pattern and magnetic resonance imaging signal intensity were evaluated.ResultsIntratumoral fat was not detected in any of the cases. On unenhanced computed tomography, the intratumoral attenuation was hyperattenuating in six of the seven patients who were examined using this modality. OnT2‐weighted images, the signal intensity of the solid component, cyst wall or septum was low in three of the four cases. Four of the eight cases were heterogeneous solid‐type accompanied by hemorrhage, necrosis or hyalinization. One homogeneous solid‐type lesion was large in size and was pathologically accompanied by neither hemorrhage nor necrosis. All three multilocular cystic types were pathologically accompanied by massive hemorrhage in the cystic component. One was accompanied by spontaneous perirenal hematoma.ConclusionsThe radiological appearance of most epithelioid angiomyolipomas has a tendency to be hyperattenuating on unenhanced computed tomography images, with low intensities onT2‐weighted images. They can be heterogeneously solid, homogeneously solid or a multilocular cystic lesion with massive hemorrhage.
Lipid profiles and persisting inflammation following critical illness in a Central Australian population: a prospective longitudinal observational study
Authors: Secombe P. J. , Brown A. , Kruger P. S. , Stewart P. C. H. 
Published: April 2013

AbstractNo published data exist following the changes in lipid profile during and after an episode of acute illness for the Australian Indigenous population. This paper presents data focusing on lipid profiles and inflammatory markers in a group of survivors of critical illness in Central Australia, prospectively recruited to a larger trial exploring the medium‐term sequelae of an intensive care unit admission. This data confirm that lipid profiles in acute illness are deranged, and that recovery may differ between indigenous and non‐indigenous populations.
Immune‐mediated cytopenias in human immunodeficiency virus: the first reported case of idiopathic aplastic anaemia successfully treated with immunosuppression
Authors: Hapgood G. , Hoy J. F. , Morrissey C. O. , Jane S. M. 
Published: April 2013

AbstractAlthough isolated cytopenias are relatively common in human immunodeficiency virus (HIV), the incidence of aplastic anaemia is extremely rare. We report here the first case of a HIV‐infected patient who developed severe idiopathic aplastic anaemia, and who was safely and effectively treated with anti‐thymocyte globulin and cyclosporin. We briefly review immune‐mediated cytopenias in HIV, including their frequency, pathophysiology and management strategies.
Expert‐based drug lists to measure anticholinergic burden: similar names, different results
Authors: LERTXUNDI Unax , DOMINGO‐ECHABURU Saioa , HERNANDEZ Rafael , PERAL Javier , MEDRANO Juan 
Published: April 2013

AbstractBackground:  Scoring scales such as the Anticholinergic Drug Scale (ADS), the Anticholinergic Risk Scale (ARS), and the Anticholinergic Cognitive Burden Scale (ACB) provide an estimation of total anticholinergic burden. Not all the lists include the same drugs, and the points given for certain drugs differ among them. Whether these discrepancies present important differences in the estimation of anticholinergic burden for an individual patient is unknown. Therefore, the aim of this study is to assess agreement among the three scales.Method:  Anticholinergic burden was measured with the three scales in 83 patients aged ≥65 years in a medium‐ and long‐stay psychiatric hospital. Subsequently, patients were categorized into three risk categories: low risk (0 points), medium risk (1–2 points) or high risk (3 or more points). The chance‐corrected measures of agreement for the different scores were determined with the k‐statistic (kappa).Results:  Values for kappa were: 0.19 for Anticholinergic Risk Scale‐Anticholinergic Drug Scale, 0.21 for ACB‐Anticholinergic Drug Scale and 0.25 for Anticholinergic Risk Scale‐ACB. The mean anticholinergic burden measured with ACB was 3.28.Conclusions:  There is poor agreement among the three scales. These lists cannot be directly applied to different settings in which drug availability differs substantially, and they require periodic updates. Anticholinergic burden in our setting (psychogeriatric inpatients) was particularly high.
Reduced memory in fat mass and obesity‐associated allele carriers among older adults with cardiovascular disease
Authors: ALOSCO Michael L. , BENITEZ Andreana , GUNSTAD John , SPITZNAGEL Mary Beth , MCCAFFERY Jeanne M. , MCGEARY John E. , POPPAS Athena , PAUL Robert H. , SWEET Lawrence H. , COHEN Ronald A. 
Published: April 2013

AbstractBackground:  Much attention has been paid to the prevalence and predisposition of the fat mass and obesity‐associated (FTO) gene to obesity, although only a few studies have characterized the extent to which this affects cognitive function. This study examined differences between risk allele carriers (i.e. FTO‐AC/AA) and non‐carriers (i.e. FTO‐CC) on indices of attention/executive function/psychomotor speed, memory, language, and visual‐spatial ability in a sample of older patients with cardiovascular disease.Methods:  We recruited 120 older adults from an outpatient cardiology clinic who underwent blood draw and completed neuropsychological testing. Participants were classified into two groups: one for those who were homozygous for the non‐risk‐conferring allele (i.e. FTO‐CC) (n= 49) and the other for those who had at least one copy of the obesity risk‐conferring A allele (i.e. FTO‐AC/AA) (n= 71).Results:  Mancova analyses adjusting for age and years of education revealed the FTO‐AC/AA group performed significantly worse on indices of memory (λ= 0.94, F(2, 115) = 3.58, P= 0.03, partial η2= 0.06). Follow‐up tests revealed a significant effect for the FTO‐AC/AA group, relative to the non‐carrier group, on encoding (i.e. California Verbal Learning Test Total Learning) and California Verbal Learning Test long‐delay free recall (P < 0.05). No such differences between FTO carriers and non‐carriers emerged on tests of attention/executive function/psychomotor speed, language, or visual‐spatial ability (P > 0.05 for all).Conclusions:  These findings suggest that the FTO risk allele is associated with reduced memory performance, particularly on aspects of memory encoding and delayed recall. To elucidate underlying mechanisms, these findings will need to be replicated in larger samples that utilize neuroimaging.
Managing abnormal eating behaviours in frontotemporal lobar degeneration patients with topiramate
Authors: SHINAGAWA Shunichiro , TSUNO Norifumi , NAKAYAMA Kazuhiko 
Published: April 2013

AbstractAbnormal eating behaviours are specific to frontotemporal lobar degeneration and increase caregiver burden. Topiramate, an anticonvulsant, suppresses cravings for alcohol and other substances and is a potential treatment for binge eating. However, there are few reports on topiramate efficacy for abnormal eating behaviours in frontotemporal lobar degeneration patients. We present three Japanese frontotemporal lobar degeneration patients with abnormal eating behaviours. Topiramate was effective, especially for compulsive eating, in cases with distinct lobar atrophy, but not for all abnormal eating behaviours.
Exploring the Issue of Employment for Adults with an Intellectual Disability in Ireland
Authors: McGlinchey Eimear , McCallion Philip , Burke Eilish , Carroll Rachel , McCarron Mary 
Published: April 2013

BackgroundThe benefits of being in employment are well documented; however, underemployment is a critical issue for people with intellectual disability (ID). Some individuals perceive themselves as being in employment when in fact they are attending a non‐work site such as a day service. The impact that this perception of employment has on other areas in life has not been investigated and research into this area could have implications for both policy makers and service providers.Materials and MethodsThe first wave of the intellectual disability Supplement to the Irish Longitudinal Study on Ageing (IDS‐TILDA) included a series of questions on employment that yielded data for a representative sample of 753 participants with intellectual disability aged 40 and over randomly selected from Ireland's National Intellectual Disability Database (NIDD).Results and DiscussionOverall, 6.6% of the population were in real paid employment, 7.4% in perceived employment, 12% in sheltered employment and 73.5% were unemployed. Differences were identified between these two groups in relation to social activities, levels of depression and self‐rated health. Further investigation is needed into the area of perceived employment.
Air‐Water Temperature Relationships in the Trout Streams of Southeastern Minnesota's Carbonate‐Sandstone Landscape
Authors: Krider Lori A. , Magner Joseph A. , Perry Jim , Vondracek Bruce , Ferrington Leonard C. 
Published: April 2013

AbstractCarbonate‐sandstone geology in southeastern Minnesota creates a heterogeneous landscape of springs, seeps, and sinkholes that supply groundwater into streams. Air temperatures are effective predictors of water temperature in surface‐water dominated streams. However, no published work investigates the relationship between air and water temperatures in groundwater‐fed streams (GWFS) across watersheds. We used simple linear regressions to examine weekly air‐water temperature relationships for 40 GWFS in southeastern Minnesota. A 40‐stream, composite linear regression model has a slope of 0.38, an intercept of 6.63, and R2 of 0.83. The regression models for GWFS have lower slopes and higher intercepts in comparison to surface‐water dominated streams. Regression models for streams with high R2 values offer promise for use as predictive tools for future climate conditions. Climate change is expected to alter the thermal regime of groundwater‐fed systems, but will do so at a slower rate than surface‐water dominated systems. A regression model of intercept vs. slope can be used to identify streams for which water temperatures are more meteorologically than groundwater controlled, and thus more vulnerable to climate change. Such relationships can be used to guide restoration vs. management strategies to protect trout streams.
A Semianalytical Solution for Residual Drawdown at a Finite Diameter Well in a Confined Aquifer
Authors: Yeh Hund‐Der , Wang Chih‐Tse 
Published: April 2013

AbstractAfter the end of pumping the water level in the observation well starts to recover and the reduced drawdown during the recovery period is named as the residual drawdown. Traditional approaches in analyzing the data of residual drawdown for estimating the aquifer hydraulic parameters are mostly based on the application of superposition principle and Theis equation. In addition, the effect of wellbore storage is commonly ignored in the evaluation even if the test well has a finite diameter. In this article, we develop a mathematical model for describing the residual drawdown with considering the wellbore storage effect and the existing drawdown distribution produced by the pumping part of the test. The Laplace‐domain solution of the model is derived using the Laplace transform technique and the time‐domain result is inverted based on the Stehfest algorithm. This new solution shows that the residual drawdown associated with the boundary and initial conditions are related to the well drawdown and the aquifer drawdown, respectively. The well residual drawdown will be overestimated by the Theis residual drawdown solution in the early recovery part if neglecting the wellbore storage. On the other hand, the Theis residual drawdown solution can be used to approximate the present residual drawdown solution in the late recovery part of the test.
A mixed methods assessment of students' flow experiences during a mobile augmented reality science game
Authors: Bressler D.M. , Bodzin A.M. 
Published: April 2013

Abstract Current studies have reported that secondary students are highly engaged while playing mobile augmented reality (AR) learning games. Some researchers have posited that players' engagement may indicate a flow experience, but no research results have confirmed this hypothesis with vision‐based AR learning games. This study investigated factors related to students' engagement – as characterized by flow theory – during a collaborative AR, forensic science mystery game using mobile devices. School Scene Investigators: The Case of the Stolen Score Sheets is a vision‐based AR game played inside the school environment with Quick Response codes. A mixed methods approach was employed with 68 urban middle school students. Data sources included pre‐ and post‐surveys, field observations and group interviews. Results showed that neither gender nor interest in science was an important predictor of variability in flow experience. Gaming attitude uniquely predicted 23% of the variance in flow experience. Student flow experience features included a flash of intensity, a sense of discovery and the desire for higher performance. The findings demonstrated a potential for mobile AR science games to increase science interest and help students learn collaboration skills. Implications for future research concerning mobile AR science games are discussed.
Treatment of Hypertension Among African Americans: The Jackson Heart Study
Authors: Harman Jane , Walker Evelyn R. , Charbonneau Vicki , Akylbekova Ermeg L. , Nelson Cheryl , Wyatt Sharon B. 
Published: April 2013

Hypertension treatment regimens used by African American adults in the Jackson Heart Study were evaluated at the first two clinical examinations (2415 treated hypertensive persons at examination I [exam I], 2000–2004; 2577 at examination II [exam II], 2005–2008). Blood pressure (BP) was below 140/90 mm Hg for 66% and 70% of treated participants at exam I and exam II, respectively. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure treatment targets were met for 56% and 61% at exam I and exam II, respectively. Persons with diabetes or chronic kidney disease were less likely to have BP at target, as were men compared with women. Thiazide diuretics were the most commonly used antihypertensive medication, and persons taking a thiazide were more likely to have their BP controlled than persons not taking them; thiazides were used significantly less among men than women. Although calcium channel blockers are often considered to be effective monotherapy for African Americans, persons using calcium channel blocker monotherapy were significantly less likely to be at target BP than persons using thiazide monotherapy.
Telmisartan/Hydrochlorothiazide Combination Therapy for the Treatment of Hypertension: A Pooled Analysis in Older and Younger Patients
Authors: Kjeldsen Sverre E. , Schumacher Helmut , Neldam Steen , Guthrie Robert M. 
Published: April 2013

Older patients frequently receive angiotensin II receptor blocker/diuretic combinations to control blood pressure (BP), although there have been relatively few trials specifically examining this patient population. A pooled analysis was performed of data from 7 randomized trials of telmisartan/hydrochlorothiazide combinations or telmisartan monotherapy in older (65 years and older) and younger (younger than 65 years) patients to better understand the response of older patients to a telmisartan/hydrochlorothiazide combination. Telmisartan doses were 40 mg and 80 mg (T40 and T80). Hydrochlorothiazide doses were 12.5 mg and 25 mg (H12.5 and H25). A total of 3654 patients were included and the mean treatment duration was approximately 8 weeks. BP reductions with telmisartan/hydrochlorothiazide combinations were broadly similar in older and younger patients. In older patients, mean BP reductions from baseline were −30.1/−19.0 mm Hg with the T80/H25 combination and −21.7/−13.0 mm Hg with T80 monotherapy. Tolerability was similar regardless of age, and the incidence of adverse events in both older and younger patients was similar to placebo. The telmisartan/hydrochlorothiazide combination, particularly high‐dose T80/H25, is effective and well tolerated in patients 65 years and older as well as in younger patients.
A New Freshwater Amoeba: Cochliopodium pentatrifurcatum n. sp. (Amoebozoa, Amorphea)
Authors: Tekle Yonas I. , Roger Anderson O. , Lecky Ariel F. , Kelly Samantha D. 
Published: April 2013

AbstractCochliopodium pentatrifurcatum n. sp. (ATCC© 30935TM) is described based on light microscopic morphology, fine structure, and molecular genetic evidence. Cochliopodium pentatrifurcatum n. sp. (length ~ 25 μm) is characterized by surface microscales (0.3 μm tall) containing a circular porous base (~ 0.6 μm diam.) with a thin peripheral rim. Five radially arranged feet, emanating from the base, support a short central column terminating apically as a funnel‐shaped collar (~ 0.5 μm diam.) composed of five radial, trifurcate rays extending from the center toward a thin peripheral rim. The central spine is 0.5–0.6 μm long. The comparative morphologies and combined molecular genetic evidence, SSU‐rDNA and COI, indicate that the new species falls in a clade sufficiently different from other species to suggest that it is a valid new species.