bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Aplikasi aSc Timetables Dalam Menyusun Roster Guru di SMA Kemala Bhayangkari 1 Medan
Authors: Harahap Baginda , Singarimbun Roy Nuary 
Published: July 2024

Program Aplikasi merupakan suatu solusi untuk permasalahan atau kendala dalam membuat jadwal roster pembelajaran disekolah satuan SMA Pendidikan, karena bisa melantas batas, ruang, dan waktu. Integrasinya pun berkecamuk kuat dugaan ambang sepuluh dasawarsa penjabaran teknologi waktu ini ini, penjabaran aplikasi asc time table bisa menjadi sarana penggarap edukasi khususnya dibidang program studi, pendidikan dan lain sebagianya, karena dibidang ini menyimpan banyak pengetahuan dalam penadwalan termasuk bagian dalam kategorisasi agenda atau roster. Pemecahan maalah itu menjadi suatu solusi dibidang pendidikan. Dari sinilah diharapkan program penjabaran asc time table ini akan lebih mmpermudah untuk membuat jadwal pembelajaran disekolah atau pada program studi dengan efektif, mudah, cepat, akurat dan relevan, serta dapat mengatasi masalah terbenturnya jadwal guru dalam mengajar, kelas jam di SMA Kemala Bhayangkari 1 Medan.
Pengembangan Aplikasi Absensi Mahasiswa Realtime Menggunakan SMS Gateway Berbasis Android
Authors: Sahrir Sahrir , Thamrin Andi Nurlinda 
Published: July 2024

Kehadiran mahasiswa tiap perkuliahan didata pada suatu absensi. Pengambilan data masih menggunakan sistem manual. Peran serta orangtua diperlukan untuk tetap mengawasi kehadiran anaknya selama proses perkuliahan. Tidak sedikit mahasiswa gagal karena mengabaikan kewajiban memenuhi frekuensi kehadiran. Penggunaan absensi menggunakan handphone berbasis android dengan layanan sms gateway diharapkan menjadi solusi dari permasalahan yang ada. Penelitian ini bertujuan untuk merancang aplikasi absensi mahasiswa PTIK secara realtime melalui SMS gateway berbasis Android. Jenis penelitian yang digunakan adalah Research and Development dengan model pengembangan sistem prototyping. Hasil dari penelitian ini adalah sebuah aplikasi absensi berbasis android disertai dengan adanya pemberitahuan ketidakhadiran mahasiswa tersampaikan kepada orangtua melalui layanan teknologi SMS gateway secara realtime. Pengujian sistem yang dilakukan menggunakan pengujian black box, validasi ahli (expert), dan tanggapan pengguna (user. Hasil dari ketiga pengujian dapat disimpulkan bahwa aplikasi layak digunakan dan berada pada kategori sangat baik.
Pengaruh Lingkungan Kerja Terhadap Kinerja Karyawan Pada PT. PLN Distribusi Jakarta Raya
Authors: Miftahudin Miftahudin 
Published: July 2024

Pentingnya menciptakan lingkungan kerja yang baik tentunya dapat memberikan kenyamanan bagi karyawan suatu perusahaan. Lingkungan kerja mempunyai peran dalam memberikan kenyamanan baik secara fisik maupun secara psikologis kepada karyawan di lingkungan perusahaan, lingkungan yang baik tentunya bisa jadi dapat meningkatkan kinerja karyawan suatu perusahaan, begitu pula sebaliknya apabila lingkungan kerja kurang tenang akan dapat mempertinggi tingkat kesalahan yang mereka lakukan. Penulis tertarik untuk mengadakan penelitian dengan variabel lingkungan kerja dan kinerja karyawan pada PT. PLN Distribusi Wilayah Jakarta Raya dengan lokasi kerja di Cempaka Putih..
Tujuan penelitian ini adalah untuk mengetahui pengaruh antara lingkungan kerja terhadap kinerja karyawan pada PT. PLN Distribusi Wilayah Jakarta Raya. Penelitian ini menggunakan metode dekriptif kuantitatif dengan teknik pengumpulan data melalui penyebaran kuesioner, dan data pustaka. Dalam penelitian ini menggunakan metode sampling jenuh berjumlah 62 karyawan pada PT. PLN Distribusi Wilayah Jakarta Raya dengan teknik analisis data regresi linear sederhana.
Hasil dari penelitian ini menunjukan bahwa terdapat pengaruh secara parsial antara lingkungan kerja terhadap kinerja karyawan pada PT. PLN Distribusi Wilayah Jakarta Raya. Hasil penelitian ini diharapkan memberikan kontribusi untuk penelitian selanjutnya.
Analisis Faktor-Faktor Yang Mempengaruhi Minat Penggunaan Uang Elektronik Pada Generasi Z
Authors: Aldiah Hanifa , Lena Sifra Varah Veronika 
Published: July 2024

Perkembangan teknologi memunculkan Fintech, inovasi keuangan modern yang mencakup pembayaran, peminjaman, transfer uang, dan jual beli saham. Di Indonesia, pembayaran elektronik memudahkan transaksi, dan uang elektronik menjadi populer. Uang elektronik, disimpan secara elektronik dan berfungsi sebagai alat pembayaran non-tunai, mengalami peningkatan signifikan dalam transaksi. Namun, mahasiswa masih kurang berminat menggunakan uang elektronik karena kurangnya informasi dan kebiasaan menggunakan uang tunai. Faktor-faktor seperti kemudahan, kepercayaan dan risiko juga mempengaruhi adopsi uang elektronik. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi minat mahasiswa Manajemen Universitas Kristen Wira Wacana Sumba dalam menggunakan uang elektronik. Metode penelitian yang digunakan adalah penelitian kuantitatif dengan teknik purposive sampling dan diperoleh jumlah sampel sebanyak 65 responden. Data dikumpulkan menggunakan kuesioner lalu dianalisis menggunakan regresi linear berganda dan data diolah menggunakan aplikasi SPSS. Dari penelitian yang telah dilakukan oleh peneliti mengunakan aplikasi SPSS menunjukkan hasil bahwa secara parsial faktor kemudahan dan kepercayaan berpengaruh terhadap minat mahasiswa Unkriswina Sumba Generasi Z, prodi Manajemen menggunakan uang elektronik. Sedangkan hasil secara parsial faktor risiko tidak berpengaruh terhadap minat mahasiswa Unkriswina Sumba Generasi Z, prodi Manajemen menggunakan uang elektronik. Berdasarkan hasil secara simultan faktor kepercayaan, faktor kemudahan dan faktor risiko berpengaruh terhadap minat mahasiswa Unkriswina Sumba Generasi Z, prodi Manajemen menggunakan uang elektronik.
Type 2 diabetes microenvironment promotes the development of Parkinson’s disease by activating microglial cell inflammation
Authors: Zhang Bohan , Song Chengyuan , Tang Xiao , Tian Min , Liu Yuqian , Yan Zhuoran , Duan Ruonan , Liu Yiming 
Published: July 2024

ObjectiveParkinson’s disease (PD) is the second most common neurodegenerative disease in the world, and type 2 diabetes (T2DM) and PD are influenced by common genetic and environmental factors. Mitochondrial dysfunction and inflammation are common pathogenic mechanisms of both diseases. However, the close association between PD and T2DM and the specific relationship between them are not yet clear. This study aimed to reveal the specific connection between the two diseases by establishing a mouse model of comorbid PD and T2DM, as well as a Bv2 cell model.MethodsC57BL/6 mouse were used to construct a model of PD with T2DM using streptozotocin and rotenone, while Bv2 cells were used to simulate the microenvironment of PD and T2DM using rotenone and palmitate. Behavioral tests were conducted to assess any differences in motor and cognitive functions in mouse. Immunohistochemistry was used to analyze the number of dopaminergic neurons in the substantia nigra region of mouse. Western blotting was used to detect the expression levels of TH, P-NFκB, NFκB, Cyclic GMP-AMP synthase (cGAS), and Stimulator of interferon genes (STING) proteins in the substantia nigra region of mouse and Bv2 cells. qRT-PCR was used to analyze the expression levels of IL1β, IL6, and TNF-α. Seahorse technology was used to assess mitochondrial function in Bv2 cells.Results:T2DM exacerbated the motor and cognitive symptoms in mouse with PD. This effect may be mediated by disrupting mitochondrial function in microglial cells, leading to damaged mtDNA leakage into the cytoplasm, subsequently activating the cGAS-STING pathway and downstream P-NFκB/NFκB proteins, triggering an inflammatory response in microglial cells. Microglial cells release inflammatory factors such as IL1β, IL6, and TNF-α, exacerbating neuronal damage caused by PD.ConclusionOur study results suggest that T2DM may exacerbate the progression of PD by damaging mitochondrial function, and activating microglial cell inflammation. The detrimental effects on Parkinson’s disease may be achieved through the activating of the cGAS-STING protein pathway.
Innovative strategies to strengthen teaching-researching skills in chemistry and biology education: a systematic literature review
Authors: Alberto Mera Cabezas Luis , Viviana Basantes Vaca Carmen , Vladimir Benavides Enríquez Celso , Fernanda Parra Alvarez Paulina 
Published: July 2024

The dynamic field of scientific education, particularly in chemistry and biology, demands the implementation of innovative teaching strategies, driving the need for continuous research to enhance skills in both educators and students. This systematic literature review (SLR) delves into the evolving landscape of chemistry and biology education research, shedding light on key trends, strategies, and skills. Employing the PRISMA methodology, we scrutinized 81 papers to assess the employment of resources, technologies, and methods conducive to effective learning and research. Searches were conducted in the Scopus and Google Scholar databases, with inclusion criteria spanning English and Spanish studies from the last five years. The analysis reveals a notable shift in recent years, emphasizing the diversification of instructional approaches, integration of sustainable practices, and a heightened focus on fostering essential research skills for both educators and students. The study underscores the significant adaptation to digital tools and virtual environments, potentially influenced by the challenges posed by the COVID-19 pandemic. Remarkable findings include the growing importance of cognitive, social, and emotional competence in student development. This work provides valuable insights for educators, researchers, and policymakers cross-talking the dynamic intersection of teaching and research in chemistry and biology education.Systematic review registration: Identifier 001-RS-FCIC-PQB-UNACH-2023.
Exploring the multifaceted antitumor activity of axitinib in lung carcinoids
Authors: Oldani Monica , Cantone Maria Celeste , Gaudenzi Germano , Carra Silvia , Dicitore Alessandra , Saronni Davide , Borghi Maria Orietta , Lombardi Angela , Caraglia Michele , Persani Luca , Vitale Giovanni 
Published: July 2024

IntroductionLung carcinoids (LCs) are a type of neuroendocrine tumor (NET) that originate in the bronchopulmonary tract. LCs account for 20–25% of all NETs and approximately 1–2% of lung cancers. Given the highly vascularized nature of NETs and their tendency to overexpress vascular growth factor receptors (VEGFR), inhibiting angiogenesis appears as a potential therapeutic target in slowing down tumor growth and spread. This study evaluated the long-term antitumor activity and related mechanisms of axitinib (AXI), a VEGFR-targeting drug, in LC cell lines.MethodsThree LC cell lines (NCI-H727, UMC-11 and NCI-H835) were incubated with their respective EC50 AXI concentrations for 6 days. At the end of the incubation, FACS experiments and Western blot analyses were performed to examine changes in the cell cycle and the activation of apoptosis. Microscopy analyses were added to describe the mechanisms of senescence and mitotic catastrophe when present.ResultsThe primary effect of AXI on LC cell lines is to arrest tumor growth through an indirect DNA damage. Notably, AXI triggers this response in diverse manners among the cell lines, such as inducing senescence or mitotic catastrophe. The drug seems to lose its efficacy when the DNA damage is mitigated, as observed in NCI-H835 cells.ConclusionThe ability of AXI to affect cell viability and proliferation in LC tumor cells highlights its potential as a therapeutic agent. The role of DNA damage and the consequent activation of senescence seem to be a prerequisite for AXI to exert its function.
Land use/land cover dynamics in the northern watershed of lake Tana: implications for water quality
Authors: Engdaw Flipos , Fetahi Tadesse , Kifle Demeke 
Published: July 2024

Rapid population growth-induced urbanization, industrialization, deforestation, settlement expansion and habitat destruction are significant drivers of LU/LC change at global scale. The uncontrolled LU/LC change, specifically in developing countries like Ethiopia, poses significant environmental threats to water quality, biodiversity, and ecosystem services. This study, therefore, examined LU/LC trends in the Lake Tana catchment, Ethiopia from 1993 to 2022, analyzed the impact of changes on water quality and identified major driving factors for policy input. ArcGIS software and Landsat imagery were employed toproduce maps for 10 years. Water quality data were obtained from primary and secondary sources from 2002 to 2022. The relationship between LU/LC changes and water quality was examined using Pearson’s correlation and principal component analysis (PCA). Results revealed significant (p&lt; 0.05) spatio-temporal variations in water quality parameters, with almost all parameters showing a substantial increase from 2002 to 2012 and some declined in 2022. LU/LC changes were categorized into six classes with an overall accuracy and Kappa coefficient of 92.2% and 0.86%, respectively. Various LU/LC classes were highly correlated with a particular water quality parameter. Settlement and crop land expansion were positively correlated with nutrients such as (NH3−+ NH4+-N), NO3-N, SRP, and TP. Forestation was positively correlated with good water quality such as DO and pH, while they were negatively correlated with temperature, EC, SRP, and NO3-N demonstrating a strong linkage between LU/LC and water quality. These findings therefore, validate the significance of prioritizing LU/LC changes for sustainable water quality and ecosystem service improvement in the Lake Tana catchment.
Genome-wide association mapping of quantitative trait loci for chalkiness-related traits in rice (Oryza sativa L.)
Authors: Xu Qing , Jiang Jianhua , Jing Chunyu , Hu Changmin , Zhang Mengyuan , Li Xinru , Shen Jiaming , Hai Mei , Zhang Ying , Wang Dezheng , Dang Xiaojing 
Published: July 2024

Grain chalkiness directly affects the commercial value of rice. Genes related to chalkiness reported thus far have been discovered in mutants, but it has not been identified whether these genes can be used to improve rice quality by breeding. Therefore, discovering more quantitative trait loci (QTLs) or genes related to chalkiness in the rice germplasm is necessary. This study entails a genome-wide association study on the degree of endosperm chalkiness (DEC) and percentage of grains with chalkiness (PGWC) by combining 1.2 million single-nucleotide polymorphisms (SNPs) with the phenotypic data of 173 rice accessions. Thirteen QTLs for DEC and nine for PGWC were identified, of which four were detected simultaneously for both DEC and PGWC; further, qDEC11/qPGWC11 was identified as the major QTL. By combining linkage disequilibrium analysis and SNP information, LOC_Os11g10170 was identified as the candidate gene for DEC. There were significant differences among the haplotypes of LOC_Os11g10170, and the Hap 1 of LOC_Os11g10170 was observed to reduce the DEC by 6.19%. The qRT-PCR results showed that the gene expression levels in accessions with high DEC values were significantly higher than those in accessions with low DEC values during days 21–42 after flowering, with a maximum at 28 days. These results provide molecular markers and germplasm resources for genetic improvement of the chalkiness-related traits in rice.
Staphylococcus aureus wraps around Candida albicans and synergistically escapes from Neutrophil extracellular traps
Authors: Jing Qi , Liu Rui , Jiang Qingsong , Liu Yingshuang , He Jinzhi , Zhou Xuedong , Yu Ollie Yiru , Chu Chun-Hung , Cheng Lei , Ren Biao , Li Mingyun 
Published: July 2024

BackgroundNETs, a unique neutrophil immune mechanism, are vital in defending against microbial invasions. Understanding the mechanisms of co-infection by Candida albicans and Staphylococcus aureus, which often leads to higher mortality and poorer prognosis, is crucial for studying infection progression.MethodsIn our study, we established a mouse model of subcutaneous infection to characterize the inflammation induced by co-infection. By purifying and extracting NETs to interact with microorganisms, we delve into the differences in their interactions with various microbial species. Additionally, we investigated the differences in NETs production by neutrophils in response to single or mixed microorganisms through the interaction between neutrophils and these microorganisms. Furthermore, we analyzed the gene expression differences during co-infection using transcriptomics.ResultsIn vivo, C. albicans infections tend to aggregate, while S. aureus infections are more diffuse. In cases of co-infection, S. aureus adheres to and wraps C. albicans. NETs exhibit strong killing capability against C. albicans but weaker efficacy against S. aureus. When NETs interact with mixed microorganisms, they preferentially target and kill the outer layer of S. aureus. In the early stages, neutrophils primarily rely on phagocytosis to kill S. aureus, but as the bacteria accumulate, they stimulate neutrophils to produce NETs. Interestingly, in the presence of neutrophils, S. aureus promotes the proliferation and hyphal growth of C. albicans.ConclusionOur research has showed substantial differences in the progression of co-infections compared to single-microbial infections, thereby providing scientific evidence for NETs as potential therapeutic targets in the treatment of co-infections.
Strategies for effective reuse of waste from abandoned buildings under sustainable development
Authors: Chen Jie , Wu Hua , Su Binyu , Li Weiqing 
Published: July 2024

Introduction: In the continuous advancement of urbanization, abandoned buildings are a huge challenge in achieving sustainable development goals. If these legacy buildings are not properly handled, they will cause a huge burden on society, economy, and the environment. Based on the material flow analysis method, an evaluation index system was constructed for legacy building resources, and a systematic study was conducted on the reuse pathways of their waste.Methods: This study focuses on the material flow, reuse pathways, and resource utilization strategies of legacy construction waste, aiming to improve the reuse efficiency of waste building materials and promote the achievement of sustainable development goals. In the study, indicator design was used to quantify the obstacles to the reuse of legacy construction waste, and social and economic costs were analyzed to ensure the comprehensiveness and scientificity of the research.Results: The experimental results show that the waste recycling rate under the implementation of this strategy reached 82.7%, and the resource utilization rate increased by 50.1%. For the obstacles to the reuse of construction waste, the network density reaches 0.052, and the overall network structure shows a lack of concentration, indicating that the current management methods for construction waste reuse have further optimization space.Discussion: The study effectively promotes the sustainable utilization of legacy buildings in cities, which is of great significance for improving the quality of urban space and promoting sustainable social development.
Prevalence, antibiotic susceptibility, and genomic analysis of Vibrio alginolyticus isolated from seafood and freshwater products in China
Authors: Sun Yanan , Yan Yanfei , Yan Shaofei , Li Fengqin , Li Ying , Yan Lin , Yang Dajin , Peng Zixin , Yang Baowei , Sun Jiali , Xu Jin , Dong Yinping , Bai Yao 
Published: July 2024

IntroductionThis study characterized Vibrio alginolyticus isolated from seafood and freshwater products in China (2020).Methods and ResultsIn total, 122 (95.31%) V. alginolyticus isolates were resistant to at least 1 antibiotic category, and 2 (1.56%) isolates were resistant to at least 3 antibiotic categories and belong to multi-drug resistance (MDR) isolates. A high prevalence rate was observed to be blaCARB (98.04%) encoding beta-lactam resistance, followed by tet (97.06%) encoding tetracycline resistance and fos (4.90%) encoding resistance to fosfomycin. Among the 57 V. alginolyticus isolates, the commonest virulence genes were type III secretion system translocated gene vopD, vopB, and vcrH (54.4%, 31/57), type III secretion system regulated gene tyeA (54.39%), followed by vscI and vscF (50.88%) encoded type III secretion system inner rod protein and needle protein, respectively. Multilocus sequence typing (MLST) showed considerable genetic diversity, with 34 distinct sequence types (STs) identified among 55 isolates. ST421 (n = 5), ST166 (n = 4), ST523 (n = 3), ST516 (n = 3), and ST507 (n = 3) were dominant STs among 55 V. alginolyticus isolates.DiscussionThese findings highlight the widespread occurrence of V. alginolyticus in both freshwater and seafood products, underscoring the critical need for vigilant monitoring of these bacteria. Such measures are essential for ensuring effective food safety management and safeguarding public health.
Quantifying neuroinflammation within deep gray matter in small vessel disease using diffusion tensor based free-water imaging: a longitudinal study
Authors: Sun Yawen , Han Xu , Li Zhenghao , Qiu Yage , Hu Ying , Zhang Yuyao , Dai Yongming , Wei Hongjiang , Xu Qun , Zhou Yan 
Published: July 2024

PurposeEmploying free water (FW) imaging, a cutting-edge diffusion MRI technique, we assessed neuroinflammation within deep gray matter (DGM) in small vessel disease (SVD) over 1–2 years.MethodOne hundred and seventy SVD patients and 21 healthy controls (HCs) underwent MRI scans and neuropsychological evaluations at baseline. These patients were then categorized into two groups: 67 displayed no cognitive impairment (NCI), while 103 exhibited vascular mild cognitive impairment (VaMCI). A follow-up study 1–2 years later included 23 from the NCI group and 28 from the VaMCI group. Calculation of FW values within DGM facilitated both cross-sectional and longitudinal analysis, revealing partial correlations between FW value changes and cognitive function alternations.ResultsBaseline examinations disclosed significant differences in DGM FW values among the three participant groups. We found increased mean FW values in the left pulvinar (Pul), bilateral lateral nuclei (LN) and bilateral internal medullary lamina of the thalamus in VaMCI participants compared with their NCI counterparts in longitudinal analysis. Notably, negative associations emerged between the FW value changes in the left Pul and the right LN of the thalamus and MoCA score changes in the VaMCI group over 1–2 years.ConclusionsThese findings support the hypothesis that increased FW value is present at the preclinical stage of SVD and remains persistent during the early course of the disease, potentially acting as the biomarker for the mechanism of underlying cognitive decline in SVD.