bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fascicular and Nonfascicular Left Ventricular Tachycardias in the Young: An International Multicenter Study
Authors: COLLINS KATHRYN K. , SCHAFFER MICHAEL S. , LIBERMAN LEONARDO , SAAREL ELIZABETH , KNECHT MARIA , TANEL RONN E. , BRADLEY DAVID , DUBIN ANNE M. , PAUL THOMAS , SALERNO JACK , BAR‐COHEN YANIV , SREERAM NARAYANSWAMI , SANATANI SHUBHAYAN , LAW IAN H. , BLAUFOX ANDREW , BATRA ANJAN , MOLTEDO JOSE M. , VAN HARE GEORGE F. , REED JOHN , RO PAMELA S. , KUGLER JOHN , ANDERSON CHRIS , TRIEDMAN JOHN K. ,   on behalf of members of the Pediatric and Congenital Electrophysiology Society
Published: January 2013

Left Ventricular Tachycardia in PediatricsIntroductionThe aim of this study was to evaluate the clinical presentation and outcomes of pediatric patients with ventricular tachycardia (VT) originating from left heart structures.Methods and ResultsThis international multicenter retrospective study including 152 patients (age 10.0 ± 5.1 years, 62% male), divided into those with fascicular VT (85%, 129/152) and nonfascicular LV VT (15%, 23/152). All patients had a normal heart structure or only a minor cardiac abnormality. Adenosine was largely ineffective in both groups (tachycardia termination in 4/74 of fascicular VT and 0/5 of nonfascicular LV VT). In fascicular VT, calcium channel blockers were effective in 80% (74/92); however, when administered orally, there was a 21% (13/62) recurrence rate. In nonfascicular LV VT, a variety of antiarrhythmic therapies were used with no one predominating. Ablation procedures were successful in 71% (72/102) of fascicular VT and 67% (12/18) of nonfascicular LV VT on an intention to treat analysis. Major complications occurred in 5 patients with fascicular VT and 1 patient with nonfascicular LV VT. After a follow‐up period of 2 years (1 day to 15 years), 72% of all patients with fascicular VT were off medications with no tachycardia recurrence. One patient died of noncardiac causes. In nonfascicular LV VT, follow‐up was 3.5 years (0.5–15 years), P = 0.38. A total of 65% of these patients were free from arrhythmias. Two patients died suddenly (P < 0.01).ConclusionThe clinical course and outcomes of pediatric patients with fascicular VT and nonfascicular LV VT are varied. Catheter ablation procedures can be curative.
A Large‐Scale Study on Storage Stability of Cloudy Apple Juice Treated by N2 and Ascorbic Acid
Authors: Tetik Nedim , Karhan Mustafa , Turhan Irfan , Aksu Mehmet , Oziyci Hatice Reyhan 
Published: January 2013

AbstractThe effect of ascorbic acid and N2 usage in large‐scale cloudy apple juice production was investigated. Samples were stored at 5 and 20C for 6 months. The quality of the initial cloudy apple juice samples was evaluated by characteristic properties (pH, total titratable acidity, total dry matter, soluble solids and total phenolic content) and storage stability was evaluated by turbidity and color parameters, which were analyzed on a monthly basis. According to the results, change in total phenolic content of the samples was considerable (minimal values were recorded in N2‐treated groups). However, ascorbic acid and N2 usage alone or in combination was not enough to prevent turbidity loss during storage. Only the lower temperature (5C) chosen was effective to decelerate this loss. In terms of color stability, the most stable group was the N2 and ascorbic acid‐treated one (ΔE: 3.59 at 5C).Practical ApplicationsColor and cloud stability are important attributes of cloudy apple juice during storage. Many laboratory studies have been conducted to improve these quality parameters. However, there is no large‐scale study about the storage stability of cloudy apple treated by N2 and ascorbic acid during the production stages. Therefore, in this study, a large‐scale cloudy apple juice production was performed using N2 and ascorbic acid during the juice processing stage and the storage stability of the final products was investigated for 6 months. The results of this large‐scale study could be useful for fruit juice processors and retailers.
THE CAUSAL LINK BETWEEN FINANCIAL INCENTIVES AND WEIGHT LOSS: AN EVIDENCE‐BASED SURVEY OF THE LITERATURE
Authors: Paloyo Alfredo R. , Reichert Arndt R. , Reinermann Holger , Tauchmann Harald 
Published: January 2013

AbstractObesity and overweight are linked to diseases that cost society a significant amount of resources. While behavior modification can reduce the problem, instigating such lifestyle changes is an uneasy task. One potential way to reduce the problem is through the use of financial incentives. In this survey, we review the available evidence, properly emphasizing studies that credibly yield meaningful estimates of the effect of financial incentives on weight loss. We find that the scientific literature on the subject has not yet satisfactorily settled whether such a mechanism is effective at eliciting the desired behavioral and health outcomes. We therefore advocate a rigorous large‐scale randomized experiment to provide reliable estimates of the effect.
Can questions about social interaction correctly identify preschool aged children with autism?
Authors: Williams Katrina , Perkins Deborah , Wheeler Danielle , Hayen Andrew , Bayl Vivian 
Published: January 2013

AimWe developed a questionnaire to assess social development (SIQ) in preschool children. Social development is often not included in medical assessment, though it may assist in early identification of autism spectrum disorder (ASD).MethodsParents of 108 children with ASD, speech and language disorders, or ‘developmental concerns’, recruited from a clinical developmental assessment and community child health service, completed the SIQ, and also a Childhood Autism Rating Scale (CARS) assessment. Receiver Operator Characteristic (ROC) curves were generated to assess the performance of different questionnaire score thresholds in correctly identifying children with a CARS score of 30 or more. Logistic regression models were used to identify the questions which had the most predictive value for a CARS score of 30 or more.ResultsAn SIQ score of 14 or more correctly identified children with a CARS ≥30 with a sensitivity of 85%, specificity 85%, positive likelihood ratio (LR) 8.3 and negative LR 0.2. Two questions were identified as most predictive of ASD.ConclusionsThe SIQ may assist clinicians in assessing social development and in making decisions about referral for autism assessment. Evaluation of the SIQ at the point of entry to a clinical service is needed.
The Global Circulation of Charles Dickens’s Novels
Authors: Gagnier Regenia 
Published: January 2013

AbstractFollowing previous contributions on Dickens within the Global Circulation Project, this essay synthesizes research on the global circulation of Dickens in this year of his Bicentenary 2012. It has two sections, beginning with the state of Dickens in the local environment of the UK and moving to the place of Dickens in current debates about World Literatures and Translation Studies. Its second and main section focuses on Dickens outside Britain, Europe, and North America, in terms of geography as well as literary traditions: New Zealand, Australia, Africa, Socialist Poland, Chinese, Japanese, and Arabic, with some reference to more widely studied areas such as Spanish, Russian, and Indian literary traditions. It urges us to think less in terms of originality and derivation than of circulation, appropriation, use, and their corollaries of transculturation, revoicing, mediation, and triangulation. When we consider the role of Dickens in cultural translation and transculturation, he has “meant” both migration and settlement, class warfare, revolution, critique of neocolonial ideological state apparatuses, care of orphans/children, critique of capitalism, socialism, gender and domestic relations, sociology and psychology of crime and deprivation, Christian solutions to social divisions and suffering, dialect, and the vernaculars of the street. He has represented extreme psychology and individual identity, for which themuletilla(in Galdós, “tagging” for Katherine Mansfield in New Zealand), a pet word or phrase repeated inadvertently showing a character’s “tic” or deep psychology, was much adapted. He has also represented the divisions between country and city, as in Henry Lawson’s studies of an Australian national ethos torn between its traditions of the bush and its rapid centralization in cities. Societies caught between traditional cultures and the forces of modernization give rise to “Dickensian” novels, “Dickensian” characters, “Dickensian” affect, “Dickensian” institutions and so forth, showing that comparable conditions give rise to formal resemblances.
Two Paths for Writing by Women in Modernist Studies
Authors: Evans Elizabeth F. 
Published: January 2013

AbstractIn its turn to transnational and interdisciplinary methods and subjects, the field of modernist studies has moved decisively away from gender‐based analyses of literary texts. Because feminist and gender‐focused scholarship played a crucial role in claiming a place for literature by women in the research and teaching of modernism, this expansionist trend raises concerns about the future of women’s literature in modernist studies. This paper argues that this path changes the questions we ask, but energizes more than sidelines the study of writing by women. Not only have expansionist tendencies in modernist studies historically been good for the inclusion of literature by women, but interdisciplinary methodologies and transnational inquiry has both invigorated work on canonical figures and provided new approaches to understudied writers. I follow a brief review of recent contributions to the study of women’s writing that take part in these developments with a more focused treatment of Dorothy Richardson studies, which have blossomed under transnational and interdisciplinary inquiry.This paper also explores another development, the significance of which for modernist studies (and the humanities more broadly) has hardly begun to be recognized: the increasing availability of digital texts and development of computational methods. We are poised to take advantage of the new accessibility of lesser‐known works, many of which have fallen out of print, in our research and teaching. Further, new technologies promise to revolutionize the ways we study literature. The digitization of literary corpora and the development of methods to mine the digitized texts for information allow us to ask new questions of literature. It remains only for scholars of modernist writing by women to continue asking new questions.
Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3‐kinase inhibitor BEZ235 and the PI3‐kinase inhibitor BKM120 in hepatocellular carcinoma
Authors: Kirstein Martha M. , Boukouris Aristeidis E. , Pothiraju Deepika , Buitrago‐Molina Laura E. , Marhenke Silke , Schütt Jutta , Orlik Johanna , Kühnel Florian , Hegermann Jan , Manns Michael P. , Vogel Arndt 
Published: January 2013

AbstractBackgroundHepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide with only few therapeutic options for patients with advanced disease. There is growing evidence indicating that activation of the PI3K/Akt/mTOR pathway plays an important role in HCC and therefore represents a promising target for novel therapeutic approaches. The aim of this study was to evaluate and compare the antitumour activity of the mTOR inhibitor RAD001, the dual mTOR and PI3‐kinase inhibitor BEZ235 and the PI3‐kinase inhibitor BKM120 in vitro and in vivo.Experimental DesignThe antitumour effects of RAD001, BEZ235 and BKM120 were analysed in seven hepatoma cell lines as mono and combination therapy with Doxorubicin, Cisplatin, Irinotecan or 5‐Flourouracil in vitro and in xenografts. Cell‐cycle progression, apoptosis, and autophagy were analysed. Furthermore, effects on mitochondrial respiration and glycolysis were assessed.ResultsTreatment with RAD001, BEZ235 and BKM120 markedly reduced tumour cell viability. Combination of PI3K inhibitors with chemotherapy was most effective. RAD001, BEZ235 and BKM120 reduced tumour growth mainly by inhibiting cell‐cycle progression rather than by inducing apoptosis. Interestingly, the antitumour effects were strongly associated with a reduction of mitochondrial respiration. BKM120, which exhibited the strongest antiproliferative effect, most strongly impaired oxidative phosphorylation compared with the other drugs.ConclusionsIn this study, BKM120 showed the strongest antitumour activity. Our findings suggest impairment of mitochondrial function as a relevant mechanism of BKM120. Moreover, combination of PI3K and mTOR inhibitors with cytotoxic agents could be promising option for non‐cirrhotic HCC patients.
The natural history and long‐term outcomes in patients with chronic hepatitis C genotype 4 after interferon‐based therapy
Authors: Alfaleh Faleh Z. , Alswat Khalid , Helmy Ahmed , Al‐hamoudi Waleed , El‐sharkawy Mohamed , Omar Mohanned , Shalaby Ahmed , Bedewi Mohaned A. , Hadad Qais , Ali Safiyya M. , Alfaleh Ahmad , Abdo Ayman A. 
Published: January 2013

AbstractBackground & AimsHepatitis C virus (HCV) genotype 4 (G4) infection is common in the Middle East. Post‐treatment long‐term outcomes have not been reported in these patients. This study evaluates these outcomes in patients after interferon‐based therapy.Patients and methodsA total of 157 patients were followed from June 2001 to February 2012. Descriptive and analytical statistics, cumulative outcomes and the independent predictors of disease progression were calculated.ResultsThe overall age was 48.0 ± 11.8 years, 75 (47.8%) were males and 53 (70.7%) of 75 who were genotyped had G4. The follow‐up period was 63.8 ± 32.8 months. Sustained virological response (SVR) was achieved in 62 (39.5%) and 24 (45.3%) patients in the whole group and the G4 subgroup respectively. Among the whole cohort and the G4 subgroup, disease progressed in 59 (37.6%) and 21 (39.6%), respectively, with less progression in the SVR groups; 15/62 (24.2%) and 3/24 (12.5%) compared with non‐responders; 44 (46.3%) and 18 (62.1%) with P = 0.01 and 0.001 respectively. Multivariate logistic regression analysis showed that having diabetes mellitus (P = 0.03), higher baseline APRI score (P = 0.00) and non‐SVR (P = 0.00) were independent predictors of disease progression. G4 patients showed similar results, but ‘non‐SVR’ (P = 0.00) was the only independent predictor of progression. Eight patients died and four developed HCC all among the non‐SVR group only.ConclusionsThis study describes, for the first time, the natural history and demonstrates the beneficial long‐term effects of interferon‐based therapy in HCV G4 patients.
Alteration assemblages in the Miller Range and Elephant Moraine regions of Antarctica: Comparisons between terrestrial igneous rocks and Martian meteorites
Authors: Hallis L. J. 
Published: January 2013

AbstractThe weathering products present in igneous terrestrial Antarctic samples were analyzed, and compared with those found in the four Miller Range nakhlite Martian meteorites. The aim of these comparisons was to determine which of the alteration phases in the Miller Range nakhlites are produced by terrestrial weathering, and what effect rock composition has on these phases. Antarctic terrestrial samples MIL 05031 and EET 96400, along with the Miller Range nakhlites MIL 03346 and 090032, were found to contain secondary alteration assemblages at their externally exposed surfaces. Despite the difference in primary mineralogy, the assemblages of these rocks consist mostly of sulfates (jarosite in MIL 05031, jarosite and gypsum in EET 96400) and iddingsite‐like Fe‐clay. As neither of the terrestrial samples contains sulfur‐bearing primary minerals, and these minerals are rare in the Miller Range nakhlites, it appears that SO42−, possibly along with some of the Na+, K+, and Ca+ in these phases, was sourced from wind‐blown sea spray and biogenic emissions from the southern ocean. Cl enrichment in the terrestrially derived “iddingsite” of MIL 05031 and MIL 03346, and the presence of halite at the exterior edge of MIL 090032, can also be explained by this process. However, jarosite within and around the olivine‐bound melt inclusions of MIL 090136 is present in the interior of the meteorite and, therefore, is probably the product of preterrestrial weathering on Mars.
Replacement versus Historical Cost Profit Rates: What is the Difference? When Does it Matter?
Authors: Basu Deepankar 
Published: January 2013

AbstractThis paper explains the Bureau of Economic Analysis methodology for computing historical cost and replacement cost measures of the net stock of capital in the US economy. It is demonstrated that there exists a threshold rate of inflation in the price of capital goods that keeps the percentage difference between the two capital stock measures constant. Hence, over periods when average inflation in the price index for capital goods is equal to the threshold value, historical cost and replacement cost profit rates would show equal percentage changes; an example of such a period for the US economy is 1946–2010.
Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum
Authors: Heinberg Adina , Siu Edwin , Stern Chaya , Lawrence Elizabeth A. , Ferdig Michael T. , Deitsch Kirk W. , Kirkman Laura A. 
Published: January 2013

SummaryResistance to antimalarials targeting the folate pathway is widespread. GTP‐cyclohydrolase (gch1), the first enzyme in this pathway, exhibits extensive copy number variation (CN) in parasite isolates from areas with a history of longstanding antifolate use. Increased CN of gch1 is associated with a greater number of point mutations in enzymes targeted by the antifolates, pyrimethamine and sulphadoxine. While these observations suggest that increases in gch1 CN are an adaptation to drug pressure, changes in CN have not been experimentally demonstrated to directly alter drug susceptibility. To determine if changes in gch1 expression alone modify pyrimethamine sensitivity, we manipulated gch1 CN in several parasite lines to test the effect on drug sensitivity. We report that increases in gch1 CN alter pyrimethamine resistance in most parasites lines. However we find evidence of a detrimental effect of very high levels of gch1 overexpression in parasite lines with high endogenous levels of gch1 expression, revealing the importance of maintaining balance in the folate pathway and implicating changes in gch1 expression in preserving proper metabolic flux. This work expands our understanding of parasite adaptation to drug pressure and provides a possible mechanism for how specific mutations become fixed within parasite populations.
Draft Genome Sequence of Fructophilic Lactobacillus florum
Authors: Kim Eun Bae , Tyler Charlotte A. , Kopit Lauren M. , Marco Maria L. 
Published: January 2013

ABSTRACT

Herein we report the first genome sequence for
Lactobacillus florum
.
L. florum
2F was isolated from Valencia orange leaves and is fructophilic, like other strains of this species. The draft genome of
L. florum
2F contains 1,261,842 bp with a
G+C
content of 41.5% in 46 contigs (≥500 bp).
Draft Genome Sequence of Rhizobium mesoamericanum STM3625, a Nitrogen-Fixing Symbiont of
Mimosa pudica
Isolated in French Guiana (South America)
Authors: Moulin Lionel , Mornico Damien , Melkonian Rémy , Klonowska Agnieszka 
Published: January 2013

ABSTRACT

Rhizobium mesoamericanum
STM3625 is a
Mimosa pudica
symbiont isolated in French Guiana. This strain serves as a model bacterium for comparison of adaptation to mutualism (symbiotic traits, bacterial genetic programs for plant infection) between alpha and beta rhizobial symbionts of
Mimosa pudica
.
Draft Genome Sequence of
Methanobacterium
sp. Maddingley, Reconstructed from Metagenomic Sequencing of a Methanogenic Microbial Consortium Enriched from Coal-Seam Gas Formation Water
Authors: Rosewarne Carly P. , Greenfield Paul , Li Dongmei , Tran-Dinh Nai , Midgley David J. , Hendry Philip 
Published: January 2013

ABSTRACT

The draft genome of
Methanobacterium
sp. Maddingley was reconstructed from metagenomic sequencing of a methanogenic microbial consortium enriched from coal-seam gas formation water. It is a hydrogenotrophic methanogen predicted to grow using hydrogen and carbon dioxide.
Aborted sudden cardiac death (SCD) in a patient with hypertrophic cardiomyopathy (HCM) with low-risk factors for SCD
Authors: Kaushik Sashank , Subramanian Stalin Ramakrishnan , Rafii Shahrokh , Castillo Ricardo 
Published: January 2013

Remarkable advancements have been made in understanding the pathophysiology of hypertrophic cardiomyopathy (HCM), since the first implantable cardioverter defibrillator (ICD) was placed in a human, more than 25 years ago to prevent sudden cardiac death (SCD). ICD has become the cornerstone in the management of HCM, with an ability to change the natural course of this complex disease. American College of Cardiology/American Heart Association guidelines have been charted out to help risk stratify asymptomatic or minimally symptomatic adults with HCM, in order to prevent SCD in such individuals. Our patient with left ventricular outflow tract gradient <30 mm Hg, left ventricular wall thickness < 30 mm, negative medical history of syncope and no family history of SCD, would have been at low risk for SCD.
Features and predictors of myocardial injury in carbon monoxide poisoned patients
Authors: Cha Yong Sung , Cha Kyoung Chul , Kim Oh Hyun , Lee Kang Hyun , Hwang Sung Oh , Kim Hyun 
Published: January 2013

Background and purposeBy contrast with neurologic injury, myocardial injury associated with carbon monoxide (CO) poisoning has not been well investigated. Therefore, this study assessed features and predictors of myocardial injury in CO poisoned patients.Subjects and methods250 CO poisoning cases that were diagnosed and treated by the emergency department of Wonju Christian Hospital from January 2006 to February 2012 were retrospectively reviewed.ResultsFifty (20%) out of 250 patients with CO poisoning developed myocardial injury. Among those with elevated troponin I (Tn I), peak levels occurred at 11.0 (IQR, 4.5–18.5) h normalising by 65.0 (IQR 44.0–96.0) h. CO exposure time, and total and ICU admission length was longer (7.5 (IQR 3.7–10.0) h vs 3.0 (IQR 1.0–7.5) h, p<0.001; 3.5 (IQR 0.0–7.0) days and 0.0 (IQR 0.0–1.25) days vs 0.0 (IQR 0.0–2.0) days and 0.0 (IQR 0.0–0.0) days, p<0.001, respectively) in the myocardial vs non-myocardial injury group. The predictors of myocardial injury were male gender, Glasgow Coma Scale (GCS) ≤14, and CO exposure time ≥2 h (OR (95% CI) of 3.341 (1.171 to 9.531), 9.920 (3.763 to 26.150), and 7.743 (1.610 to 37.238), respectively).ConclusionsMyocardial injury developed in 20% of CO poisoned patients. Time to normalisation and of peak Tn I level in elevated Tn I group was 65.0 (IQR 44.0–96.0) h and 11.0 (IQR 4.5–18.5) h. Presence of myocardial injury was associated with poorer prognosis. Predictors of myocardial injury included male gender, GCS of 14 or less, or CO exposure times greater than 2 h.