bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PEMBERIAN TEMULAWAK TERHADAP NAFSU MAKAN PADA ANAK
Authors: Wilujeng Atik Pramesti , Trianita Desi , Setyastuti Endang 
Published: July 2024

Pendahuluan : Jatuh merupakan hal yang paling sering terjadi pada lansia. Oleh karena itu lansia membutuhkan intervensi yang tepat untuk mencegah terjadinya jatuh. Pijat kaki merupakan salah satu intervensi yang dapat membantu lansia mengatasi masalah kesehatan tersebut. Tujuan: untuk menilai efektifitas pijat kaki terhadap keseimbangan lansia dengan melihat durasi waktu yang digunakan, manfaat pemberian pijat kaki, instrument penilaian keseimbangan. Metode: pencarian artikel melalui database berbasis elektronik PubMed, Science Direct, Wiley Online, dan Google Scholars. Hasil: review dari enam artikel yang terdiri dari dua penelitian Randomized Control Trial (RCT) dan empat penelitian Quasi-Experiment membahas mengenai keefektifan pijat kaki terhadap keseimbangan. Diperoleh durasi waktu pemberian pijat kaki selama 10 menit untuk masing-masing kaki, penilaian resiko jatuh yang paling efektif digunakan adalah dengan menggunakan pengkuran TUG, serta beberapa manfaat dari pijat kaki diantaranya dalam meningkatkan keseimbangan yang secara signifikan ditunjukkan oleh peningkatan TUG, meningkatkan fleksibilitas dan fungsi keseimbangan sendi pergelangan kaki, dan dapat menjadi pengobatan alternatif yang layak untuk kinerja meningkatkan keseimbangan, ROM kaki, dan sensasi kaki pada pasien diabetes dengan neuropati perifer. Kesimpulan: pijat kaki sangat bermanfaat untuk dilakukan pada lansia untuk meningkatkan status kesehatan dan dapat mencegah resiko terjadinya jatuh
A case report on pituitary tuberculosis
Authors: Shefin Sultana Marufa , Rubaiya Afsana , Kamal Mohammed , Hasan Sarkar Md Murshed 
Published: July 2024

Tuberculosis is an infectious disease that involves any organ. However, the primary pituitary tuberculosis is an extremely rare disease. Intracranial tuberculomas account for 0.15-5% of intracranial space-occupying lesions, of which, pituitary as the primary site is unusual, and easily misdiagnosed as pituitary adenoma. In this setting, the late diagnosis can result in permanent endocrine dysfunction. We report the case of a 28-year-old woman who presented to the endocrinology department with complaints of progressively increasing headache for 1 month and double vision. On the clinical examination, the patient was conscious and oriented. The routine hematological and biochemical workup showed an increased erythrocyte sedimentation rate (ESR) and increased prolactin levels. MRI scan of Brain reveals Pituitary macroadenoma with impingement upon the optic chaisma, no other significant abnormality is detected in the brain. No other radiological and/or clinical clue that could elicit the suspicion of pulmonary or extrapulmonary lesions of tuberculosis was found. The Endoscopic Transnasal Transphenoidal Surgery was done. The histopathological examination of multiple irregular tissue from excised tumor was Granulomatous inflammation and the final diagnosis of pituitary tuberculoma was made. We report this rare case of pituitary lesion that may be included in the differential diagnosis of sellar lesions to avoid unnecessary surgical interventions, especially in regions where the disease is endemic.
Bangladesh Journal of Medical Science Vol. 23 No. 03 July’24 Page : 864-868
Influencia de la red de apoyo en la salud mental de jóvenes embarazadas
Authors: Cardona Berti Alana , Pino Gaitán Valeria I. , Oviedo Céspedes Diana C. 
Published: July 2024

La maternidad implica una serie de cambios biopsicosociales que pueden propiciar la aparición de alteraciones en la salud mental, especialmente cuando el embarazo no es planificado y las madres no cuentan con soporte emocional. El objetivo del estudio fue analizar la influencia que tienen las redes de apoyo en la salud mental de adolescentes y adultas jóvenes embarazadas de 18 años a 24 años en Panamá. Este fue un estudio piloto con metodología mixta, descriptivo y transversal. La muestra estuvo compuesta por mujeres jóvenes entre 18 años y 24 años que asistieron a la clínica de la Asociación Panameña para el Planeamiento de la Familia de San Miguelito, Panamá, durante el primer semestre del 2022. Se utilizó la Escala de Autoestima de Rosenberg, el Inventario de Ansiedad de Beck, el Inventario de Depresión de Beck y un cuestionario sociodemográfico. La media de edad de la muestra fue de 22.6 años. El 100% de la muestra aseguró contar con al menos una red de apoyo. El 33.3% obtuvo una autoestima elevada y 88.9% obtuvo niveles bajos de ansiedad y depresión. Se encontraron relaciones significativas entre los resultados de ansiedad y autoestima (p= 0.029), depresión y autoestima (p= 0.041), y ansiedad y depresión (p= 0.007). El análisis cualitativo arrojó que todas las participantes consideraron relevante contar con el apoyo de su pareja y/o familia. Las redes de apoyo ayudan a potenciar el bienestar de las madres jóvenes; a su vez, esto puede servir como factor protector ante la aparición de ansiedad y depresión.
ANALISIS KONSEP EFISIENSI EKONOMI DALAM ISLAM: KAJIAN TERHADAP QS. AL-ISRA AYAT 26-29
Authors: Fauzia Ulirrahmi  
Published: July 2024

Penelitian ini mengulas konsep efisiensi ekonomi dalam perspektif Islam, dengan fokus pada ayat-ayat QS. Al-Isra ayat 26-29. Efisiensi ekonomi dalam Islam dianalisis melalui pedoman dan prinsip-prinsip etis yang terkandung dalam ayat-ayat tersebut. Temuan penelitian ini mengindikasikan bahwa Islam menekankan pentingnya pengelolaan sumber daya yang bijaksana, distribusi kekayaan yang adil, etika dalam bertransaksi, dan keseimbangan dalam penggunaan harta. Efisiensi ekonomi dalam Islam juga memperhatikan keadilan sosial, moralitas, dan nilai-nilai moral sehingga tidak hanya terfokus pada profitabilitas semata. Secara keseluruhan, ayat-ayat dalam QS. Al-Isra ayat 26-29 memberikan panduan tentang konsep efisiensi ekonomi dalam Islam yaitu mencakup distribusi yang adil, penghindaran pemborosan, penekanan pada etika dalam transaksi ekonomi, dan keseimbangan dalam mengalokasikan sumber daya. Prinsip-prinsip ini dapat membantu masyarakat dapat mencapai efisiensi ekonomi yang berkelanjutan dengan tetap mempertimbangkan nilai-nilai moral dan sosial.
The frozen elephant trunk technique in acute aortic dissection: the ultimate solution? An institutional experience
Authors: Wisniewski K. , Dell’Aquila A. M. , Motekallemi A. , Oberhuber A. , Schäfers J. F. , Marchiori E. , Weber R. , Martens S. , Rukosujew A. 
Published: July 2024

ObjectiveAcute aortic dissection remains a serious emergency in the field of cardiovascular medicine and a challenge for cardiothoracic surgeons. In the present study, we seek to compare the outcomes of different surgical techniques in the repair of type A acute aortic dissection.MethodsBetween April 2015 and May 2023, 213 patients (82 women, aged: 63.9 ± 13.3 years) with acute aortic dissection (205 type A and 8 non-A-non-B dissections) underwent surgical treatment in our department. A total of 45 patients were treated with the frozen elephant trunk (FET) technique supported by the Thoraflex™ Hybrid prosthesis, 33 received total aortic arch replacement (TAR)—standard or conventional elephant trunk—treatment, and 135 were treated with hemiarch replacement (HR). Aortic arch surgery was performed in most patients under moderate hypothermic (28°C on average) circulatory arrest, with selective antegrade cerebral perfusion through the right axillary artery.ResultsThe rates of early mortality were 17.8% (38 perioperative deaths) in the whole population, 8.9% in the FET group of patients, and 33% and 17% in the TAR and HR group of patients, respectively (P-value 0.025). The rate of spinal cord injury was 2.3% (five patients), and a paresis of recurrent laryngeal occurred in 3.7% of patients (seven patients, four were treated with FET). Permanent neurological dysfunction occurred in 27 patients (12.7%). After a mean follow-up of 3 years, the rate of mid-term mortality of discharged patients was 19.4% (34 deaths: 7 FET, 4 TAR, and 23 HR) and the overall mortality rate was 33.8% [72 deaths: 11 FET (24.4%); 15 TAR (45.4%); 46 HR (34.1%)]. A total of 8 patients (17.8%) in whom FET was applied received additional endovascular treatment in the descending aorta.ConclusionsIn our institutional experience, we found that the frozen elephant trunk technique with a high-end Thoraflex Hybrid prosthesis proved its surgical suitability in the treatment of acute aortic dissection with favorable outcomes. The FET technique and our perioperative management led to comparable neurological outcomes and reduced mortality rates in these emergency cases.
Left ventricular unloading with gentle chest compressions for patients on veno-arterial extracorporeal membrane oxygenation: two case reports
Authors: Jiang Lingyu , Huang Minyan , Xiang Shulin , Xiong Bin , Li Guibin , Zhong Yonglong , Han Lin 
Published: July 2024

BackgroundInsufficient ventricular unloading is a serious complication during veno-arterial extracorporeal membrane oxygenation (VA-ECMO) that has a crucial impact on patient outcomes. The existing conservative treatment options are limited, while mechanical decompression techniques are challenging and restricted in terms of their adoption and application. Two patients with cardiogenic shock experienced insufficient left ventricular unloading with no pulsatile contraction and aortic valve closure during VA-ECMO support. Gentle chest compression was applied to establish an active left ventricular drainage mechanism, which prevented the formation of intracardiac thrombi. No life-threatening complications or technical problems occurred. Therefore, gentle chest compression was established as an effective and safe method for treating insufficient left ventricular unloading in VA-ECMO patients.
The longitudinal characterization of immune responses in COVID-19 patients reveals novel prognostic signatures for disease severity, patients’ survival and long COVID
Authors: Noviello Maddalena , De Lorenzo Rebecca , Chimienti Raniero , Maugeri Norma , De Lalla Claudia , Siracusano Gabriel , Lorè Nicola Ivan , Rancoita Paola Maria Vittoria , Cugnata Federica , Tassi Elena , Dispinseri Stefania , Abbati Danilo , Beretta Valeria , Ruggiero Eliana , Manfredi Francesco , Merolla Aurora , Cantarelli Elisa , Tresoldi Cristina , Pastori Claudia , Caccia Roberta , Sironi Francesca , Marzinotto Ilaria , Saliu Fabio , Ghezzi Silvia , Lampasona Vito , Vicenzi Elisa , Cinque Paola , Manfredi Angelo Andrea , Scarlatti Gabriella , Dellabona Paolo , Lopalco Lucia , Di Serio Clelia , Malnati Mauro , Ciceri Fabio , Rovere-Querini Patrizia , Bonini Chiara 
Published: July 2024

IntroductionSARS-CoV-2 pandemic still poses a significant burden on global health and economy, especially for symptoms persisting beyond the acute disease. COVID-19 manifests with various degrees of severity and the identification of early biomarkers capable of stratifying patient based on risk of progression could allow tailored treatments.MethodsWe longitudinally analyzed 67 patients, classified according to a WHO ordinal scale as having Mild, Moderate, or Severe COVID-19. Peripheral blood samples were prospectively collected at hospital admission and during a 6-month follow-up after discharge. Several subsets and markers of the innate and adaptive immunity were monitored as putative factors associated with COVID-19 symptoms.ResultsMore than 50 immunological parameters were associated with disease severity. A decision tree including the main clinical, laboratory, and biological variables at admission identified low NK-cell precursors and CD14+CD91+ monocytes, and high CD8+ Effector Memory T cell frequencies as the most robust immunological correlates of COVID-19 severity and reduced survival. Moreover, low regulatory B-cell frequency at one month was associated with the susceptibility to develop long COVID at six months, likely due to their immunomodulatory ability.DiscussionThese results highlight the profound perturbation of the immune response during COVID-19. The evaluation of specific innate and adaptive immune-cell subsets allows to distinguish between different acute and persistent COVID-19 symptoms.
Inhibition of B cell receptor signaling induced by the human adenovirus species D E3/49K protein
Authors: Hildenbrand Andreas , Cramer Precious , Bertolotti Milena , Kaiser Nathalie Sophia , Kläsener Kathrin , Nickel Clara Muriel , Reth Michael , Heim Albert , Hengel Hartmut , Burgert Hans-Gerhard , Ruzsics Zsolt 
Published: July 2024

IntroductionThe early transcription unit 3 (E3) of human adenoviruses (HAdVs) encodes several immunoevasins, including the E3/49K protein, which is unique for species D of HAdVs. It is expressed as surface transmembrane protein and shed. E3/49K of HAdV-D64 binds to the protein tyrosine phosphatase surface receptor CD45, thereby modulating activation of T and NK cells.MethodsConsidering that E3/49K represents the most polymorphic viral protein among species D HAdVs, we demonstrate here that all tested E3/49K orthologs bind to the immunologically important regulator CD45. Thus, this feature is conserved regardless of the pathological associations of the respective HAdV types.ResultsIt appeared that modulation of CD45 is a unique property restricted to HAdVs of species D. Moreover, E3/49K treatment inhibited B cell receptor (BCR) signaling and impaired BCR signal phenotypes. The latter were highly comparable to B cells having defects in the expression of CD45, suggesting E3/49K as a potential tool to investigate CD45 specific functions.ConclusionWe identified B cells as new direct target of E3/49K-mediated immune modulation, representing a novel viral immunosubversive mechanism.
Factor H-related protein 1 in systemic lupus erythematosus
Authors: Kleer Jessica S. , Klehr Juliane , Dubler Denise , Infanti Laura , Chizzolini Carlo , Huynh-Do Uyen , Ribi Camillo , Trendelenburg Marten 
Published: July 2024

BackgroundFactor H (FH) is a major soluble inhibitor of the complement system and part of a family comprising five related proteins (FHRs 1–5). Deficiency of FHR1 was described to be linked to an elevated risk of systemic lupus erythematosus (SLE). As FHR1 can partially antagonize the functionality of FH, an altered FHR1/FH ratio could not only enhance SLE vulnerability but also affect the disease expression. This study focuses on the analysis of FH and FHR1 at a protein level, and the occurrence of anti-FH autoantibodies (anti-FH) in a large cohort of SLE patients to explore their association with disease activity and/or expression.MethodsWe assessed FH and FHR1 levels in plasma from 378 SLE patients compared to 84 healthy controls (normal human plasma, NHP), and sera from another cohort of 84 healthy individuals (normal human serum, NHS), using RayBio® CFH and CFHR1 ELISA kits. Patients were recruited by the Swiss SLE Cohort Study (SSCS). Unmeasurable FHR1 levels were all confirmed by Western blot, and in a subgroup of patients by PCR. Anti-FH were measured in SLE patients with non-detectable FHR1 levels and matched control patients using Abnova’s CFH IgG ELISA kit.ResultsOverall, FH and FHR1 levels were significantly higher in healthy controls, but there was no significant difference in FHR1/FH ratios between SLE patients and NHPs. However, SLE patients showed a significantly higher prevalence of undetectable FHR1 compared to all healthy controls (35/378 SLE patients versus 6/168 healthy controls; p= 0.0214, OR=2.751, 95% CI = 1.115 – 8.164), with a consistent trend across all ethnic subgroups. Levels of FH and FHR1, FHR1/FH ratios and absence of FHR1 were not consistently associated with disease activity and/or specific disease manifestations, but absence of FHR1 (primarily equivalent to CFHR1 deficiency) was linked to the presence of anti-FH in SLE patients (p=0.039).ConclusionsDeficiency of FHR1 is associated with a markedly elevated risk of developing SLE. A small proportion of FHR1-deficient SLE patients was found to have autoantibodies against FH but did not show clinical signs of microangiopathy.
Efficacy and safety of extracorporeal shock wave therapy for upper limb tendonitis: a systematic review and meta-analysis of randomized controlled trials
Authors: Xiong Yongqing , Wen Tianshan , Jin Songzhi , Lin Ling , Shao Qianer , Peng Yue , Zheng Qining , Li Wei 
Published: July 2024

ObjectiveThis study synthesized the highest level of evidence to analyse the effectiveness and safety of using extracorporeal shock wave therapy (ESWT) to treat upper limb tendonitis, which was unknown.DesignWe conducted a systematic review and meta-analysis of 18 randomized controlled trials (RCTs) in PubMed, Embase, Web of Science, Medline, and the Cochrane Library.MethodsTwo researchers performed the screening, data extraction, literature quality assessment, and heterogeneity analysis of the searched RCTs.ResultsThe main types of morbidity included rotator cuff tendonitis, lateral epicondylitis, finger tendonitis, and long bicipital tendonitis. The results of the meta-analysis showed that ESWT was effective in relieving pain in all four types of tendonitis. In addition, ESWT was more effective in relieving pain in patients with upper limb tendonitis than placebo at the 3- and 6-month follow-ups, especially with radial ESWT (RESWT). Data analysis of the forest plot showed that the experimental group with ESWT as an intervention had a significant improvement in function in patients with rotator cuff tendonitis at the 3-month follow-up. However, subgroup analysis showed that low-energy ESWT was effective in improving function in patients with calcified and non-calcified rotator cuff tendonitis, whereas it was not effective in relieving pain.ConclusionESWT can effectively improve the functional activity in patients with rotator cuff tendonitis and may produce positive analgesic effects in patients with upper limb tendonitis. The incidence of adverse effects is low.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023403594, identifier: PROSPERO, CRD42023403594.
Vascular ultrasound as a follow-up tool in patients with giant cell arteritis: a prospective observational cohort study
Authors: Haaversen Anne C. B. , Brekke Lene Kristin , Kermani Tanaz A. , Molberg Øyvind , Diamantopoulos Andreas P. 
Published: July 2024

ObjectivesTo evaluate relapses in giant cell arteritis (GCA), investigate the utility of vascular ultrasound to detect relapses, and develop and assess a composite score for GCA disease activity (GCAS) based on clinical symptoms, ultrasound imaging activity, and C-reactive protein (CRP).MethodsPatients with GCA were prospectively followed with scheduled visits, including assessment for clinical relapse, protocol ultrasound examination, and CRP. At each visit, patients were defined as having ultrasound remission or relapse. GCAS was calculated at every visit.ResultsThe study included 132 patients, with a median follow-up time of 25 months [interquartile range (IR) 21]. The clinical relapse rate was 60.6%. There were no differences in relapse rates between GCA subtypes (cranial-GCA, large vessel (LV)-GCA, and mixed-GCA) (p = 0.83). Ultrasound yielded a sensitivity of 61.2% and a specificity of 72.3% for diagnosing GCA- relapse in our cohort. In 7.7% of follow-up visits with clinical relapses, neither high CRP nor findings of ultrasound relapse were registered. In comparison, in 10.3% of follow-up visits without symptoms of clinical relapse, there were both a high CRP and findings of ultrasound relapse.ConclusionWe found moderate sensitivity and specificity for ultrasound as a monitoring tool for relapse in this prospective cohort of GCA patients. The extent or subtype of vasculitis at the diagnosis did not influence the number of relapses. Based on a combination of clinical symptoms, elevated CRP, and ultrasound findings, a composite score for GCA activity is proposed.
A bibliometric analysis of light chain amyloidosis from 2005 to 2024: research trends and hot spots
Authors: Liu Xiangdong , Wang Junyan , Li Yingmin , Shi Weibo , Zhang Xiaojing , Li Shujin , Cong Bin 
Published: July 2024

BackgroundLight chain (AL) amyloidosis stands as the most prevalent subtype of systemic amyloidosis, encompassing a group of rare diseases. Here, we evaluated the scientific landscape of AL amyloidosis to investigate research trends and identify hotspots within the field.MethodsRelevant studies on AL amyloidosis published over the past two decades were retrieved from the Web of Science Core Collection. The publications between 2005 and 2024 were subjected to bibliometric analyses, leveraging tools including CiteSpace, VOSviewer, RStudio and MS Excel to analyse and visualize the annual publication trend, co-occurrence patterns, collaborative networks among countries, organizations, and authors. Burst keywords and references were also examined to obtain the research history, and emerging hotspots.ResultsThe bibliometric analysis included 2,864 articles published between 2005 and 2024. The most productive journal is Amyloid-Journal of Protein Folding Disorders. The United States, along with several developed nations, emerges as a dominant force in international AL amyloidosis research. “AL amyloidosis” and “cardiac amyloidosis” were the primary hotspots over the past two decades, and “Biomarkers,” “Cardiac amyloidosis,” and “treatment” would be future trends.ConclusionThis bibliometric analysis examined the research developments in AL amyloidosis over the past two decades using bibliometric software. Recent research in this field primarily focuses on two main areas: clinical diagnosis and treatment of AL amyloidosis, as well as cardiac amyloidosis. Emphasis is placed on understanding the mechanisms underlying immunoglobulin light chain aggregation and deposition to mitigate organ involvement.
Shifts in the gut microbiota of sea urchin Diadema antillarum associated with the 2022 disease outbreak
Authors: Ruiz-Barrionuevo Juliana M. , Kardas Elif , Rodríguez-Barreras Ruber , Quiñones-Otero Marcos A. , Ruiz-Diaz Claudia P. , Toledo-Hernández Carlos , Godoy-Vitorino Filipa 
Published: July 2024

IntroductionIn recent decades, Caribbean coral reefs have lost many vital marine species due to diseases. The well-documented mass mortality event of the long-spined black sea urchin Diadema antillarum in the early 1980s stands out among these collapses. This die-off killed over 90% of D. antillarum changing the reefscape from coral to algal-dominated. Nearly 40 years later, D. antillarum populations have yet to recover. In early 2022, a new mortality event of D. antillarum was reported along the Caribbean, including Puerto Rico.MethodsThis study identifies the gut microbiota changes associated with the D. antillarum during this mortality event. It contrasts them with the bacterial composition of gut samples from healthy individuals collected in 2019 by using 16S rRNA sequencing analyses.ResultsNotably, the die-off group’s core microbiome resembled bacteria commonly found in the human skin and gut, suggesting potential anthropogenic contamination and wastewater pollution as contributing factors to the 2022 dysbiosis. The animals collected in 2022, especially those with signs of disease, lacked keystone taxa normally found in Diadema including Photobacterium and Propionigenium.DiscussionThe association between human microbes and disease stages in the long-spined urchin D. antillarum, especially in relation to anthropogenic contamination, highlights a complex interplay between environmental stressors and marine health. While these microbes might not be the direct cause of death in this species of sea urchins, their presence and proliferation can indicate underlying issues, such as immune depletion due to pollution, habitat destruction, or climate change, that ultimately compromise the health of these marine organisms.