bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrent Acute Myocardial Infarction and Acute Ischemic Stroke in a Diabetic Patient Undergoing Chemotherapy for Non-Hodgkin Lymphoma:Should I administer thrombolytic therapy? A Case Report
Authors: Shayo Sigfrid Casmir , Khanbai Khuzeima , Gandye Yona , Kiroga Nakigunda , Waane Tatizo , Kisenge Peter 
Published: June 2024

Abstract

Background
Concurrent ST-elevation myocardial infarction (STEMI) and acute ischemic stroke (AIS) are extremely rare, and their management remains perplexing due to the absence of high-quality evidence and limited resources. For the first time, we report a rare, preventable and suboptimallymanaged case of concurrent AIS and STEMI in a patient with non-Hodgkin lymphoma (NHL) who received cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) chemotherapy.
Case Presentation
A postmenopausal woman of African origin with a background history of type 2 diabetes mellitus presented to the Jakaya Kikwete Cardiac Institute with sudden onset of left-sided weakness and typical ischemic chest pain for 3 days. The patient was recently diagnosed with NHL and started CHOP chemotherapy 3 weeks prior. Physical examination revealed left-sided hemiplegia. Emergency brain computed tomography (CT) and 12-lead echocardiography (ECG) revealed AIS and STEMI, respectively. A diagnosis of concurrent AIS and STEMI was reached, and the patient was loaded with dual antiplatelets and heparin and rushed for emergency coronary angiography (GAG) and percutaneous coronary intervention (PCI). CAG revealed massive thrombotic occlusion of the mid-segment of the left anterior descending coronary artery (mLAD) and proximal segment of the right coronary artery. Revascularization was achieved in both vessels with a resultant TIMI flow grade of 3. The post-PCI period was marked bysignificant improvement inchest pain and resolution of ST-elevation, as revealed by 12-lead ECG. However, the patient remained hemiplegic.
Conclusion
We have described a rare case of concurrent AIS and STEMI in a postmenopausal woman who had a significant risk of thromboembolism. The patient had uncontrolled type 2 diabetes and received CHOP chemotherapy for NHL, which was diagnosed 3 weeks prior. This case underscores the need for thromboembolic prophylaxis for selected cancer patients receiving chemotherapy. The need to individualize management is also emphasized,as both PCI and thrombolysis carry therisk of serious repercussions. In our patient, if thrombolysis was attempted it would have caused myocardial ruptureand immediate death. The patient would have benefited from endovascular mechanical embolectomy for AIS;however, this practice is lacking at our institution. This calls for the establishment and strengthening of neurointerventional practices in our tertiary healthcare facilities.
Accuracy Standards of Wearable Technologies for Assessment of Soccer Kicking: Protocol for a Systematic Literature Review
Authors: Palucci Vieira Luiz H , Clemente Filipe Manuel , Chang Marquez Felipe Armando , Rea Olivares Walter Manuel , Vargas Villafuerte Kelly R , Carpes Felipe P 
Published: June 2024

Background
Wearable technology is widely applied in performance monitoring, an integral part of sports and exercise sciences. The kick movement in soccer exemplifies a sports technique that could benefit from appropriate biomechanics assessment methodologies. However, the accuracy of wearables in quantifying soccer kick mechanics, particularly under field conditions, remains unclear.

Objective
This study aims to present a protocol for a systematic review to discuss the measurement properties (validity, reliability, and/or accuracy aspects) of wearable technology systems explicitly used to measure ball-kicking features in soccer.

Methods
This review protocol was preregistered in the Open Science Framework. A total of 2 authors will perform searches in major electronic databases using specific keyword combinations in PubMed, Physical Therapy and Sports Medicine, Web of Science, ProQuest, IEEE Xplore, EBSCOHost, and Scopus. Following a specific population, intervention, comparison, outcome framework (population: soccer players and/or collected human data in a football-related environment; intervention: at least 1 wearable used; comparator: criterion measures, repeated testing sessions and/or actual values; outcome: ball kicking data), studies will be screened based on predetermined inclusion and exclusion criteria. The methodological quality of the included studies will be assessed using the “consensus-based standards for the selection of health measurement instruments” checklist (in studies concerning validity or reliability) or the “quality assessment of diagnostic accuracy studies” tool (in studies concerning accuracy). Data extraction will be conducted to determine the level of evidence according to the “best evidence synthesis method,” and an evidence gap map will be constructed. The Cohen κ coefficient will be used to estimate the interevaluator agreement.

Results
This ongoing systematic review has completed database searches and is currently in the screening phase. Depending on the number and consistency of studies, results may be presented by meta-analysis or qualitative synthesis, with subgroup analyses considering factors such as gender, age, and playing level. The final results are expected by July 2024, with manuscript submission anticipated by November 2024.

Conclusions
Our study will provide a comprehensive summary of the highest level of evidence available on the use of wearables for the assessment of soccer kick mechanics, providing practical guidance for athletes and sports sciences professionals regarding the validity and reliability aspects of using wearable technology to measure ball-kicking features in soccer.

Trial Registration
OSF registries https://osf.io/zm3j6

International Registered Report Identifier (IRRID)
DERR1-10.2196/57433
PATRIMONIO FAMILIAR EN NUESTRO MUSEO
Authors: Cuevas Figueroa Catalina , Peralta Toledo Lilian Celedina 
Published: June 2024

La presente propuesta didáctica es una alternativa de trabajo a una temática invisibilizada en el currículum nacional chileno, como lo es la Educación Patrimonial para estudiantes de Primer Ciclo de Educación Básica en colegios chilenos, con estudiantes de un rango etario de 7 a 12 años de edad, para ser desarrollada de forma extracurricular. En esta propuesta se combina la escuela y el museo no sólo como un espacio de aprendizaje, sino que pretende exponer parte de la historia personal de los niños participantes. Esta propuesta pedagógica parte desde una investigación bibliográfica sobre los conceptos de Educación Patrimonial, patrimonio familiar, identidad, memoria y museo, investigación desde la que se construyó la propuesta didáctica. El objetivo de esta propuesta didáctica es indagar, comprender y valorar la identidad familiar de las y los estudiantes, a través de una investigación y exposición de objetos de patrimonio familiar presentes en un museo auto-gestionado. Para lograr lo anteriormente señalado, hemos organizado el escrito de la siguiente manera: primero, señalaremos la introducción, contexto y la explicación teórica de los conceptos claves. En segundo lugar, presentaremos la propuesta didáctica organizada en nueve clases, instrumentos de evaluación y guion de entrevista. En tercer lugar, se comparten las proyecciones y conclusiones finales.
Effects of bone anchored maxillary protraction on patients with unilateral cleft lip/palate or isolated cleft palate and hypoplastic maxilla: a 6-year follow-up case control study
Authors: Kiukkonen Anu , Rice David , Railavo Sirpa 
Published: June 2024

ABSTRACT

Objectives
To evaluate the effects of bone-anchored maxillary protraction (BAMP) treatment and longterm stability in growing cleft lip and palate and isolated cleft palate (CLP/CP) patients with mild maxillary hypoplasia and to compare maxillary growth patterns of BAMP-treated patients to matched control CLP/CP patients.

Materials and Methods
Ten patients with CLP/CP were treated with BAMP; they were compared to the maxillary growth pattern of 10 age-matched cleft control patients with no maxillary protraction treatment, who later received surgical Le Fort I maxillary advancement after the growth period. The assessment of maxillary growth and the occlusion started at mean 8 years of age and continued until mean 18 years of age.

Results
The use of BAMP orthopedic traction changed the growth pattern of mild hypoplastic maxilla toward a more anterior direction and advanced the face even above the level of Le Fort lll with only a minor effect on dentoalveolar units. The correction of occlusion and facial convexity were stable in the long term.

Conclusions
The using BAMP may improve the position of the maxilla relative to the anterior cranial base for the correction of mild maxillary hypoplasia in adolescent patients with CLP/CP. The achieved results are rather stable in the long term.
The Association Between Depressive Symptoms, Access to Diabetes Care, and Glycemic Control in Five Middle-Income Countries
Authors: Merkel Lena , Teufel Felix , Malta Deborah Carvalho , Theilmann Michaela , Marcus Maja-Emilia , Flood David , Geldsetzer Pascal , Manne-Goehler Jennifer , Petrak Frank , Vollmer Sebastian , Davies Justine 
Published: June 2024

OBJECTIVE
The relationship between depression, diabetes, and access to diabetes care is established in high-income countries (HICs) but not in middle-income countries (MICs), where contexts and health systems differ and may impact this relationship. In this study, we investigate access to diabetes care for individuals with and without depressive symptoms in MICs.

RESEARCH DESIGN AND METHODS
We analyzed pooled data from nationally representative household surveys across Brazil, Chile, China, Indonesia, and Mexico. Validated survey tools Center for Epidemiologic Studies Depression Scale Revised, Composite International Diagnostic Interview, Short Form, and Patient Health Questionnaire identified participants with depressive symptoms. Diabetes, defined per World Health Organization Package of Essential Noncommunicable Disease Interventions guidelines, included self-reported medication use and biochemical data. The primary focus was on tracking diabetes care progression through the stages of diagnosis, treatment, and glycemic control. Descriptive and multivariable logistic regression analyses, accounting for gender, age, education, and BMI, examined diabetes prevalence and care continuum progression.

RESULTS
The pooled sample included 18,301 individuals aged 50 years and above; 3,309 (18.1%) had diabetes, and 3,934 (21.5%) exhibited depressive symptoms. Diabetes prevalence was insignificantly higher among those with depressive symptoms (28.9%) compared with those without (23.8%, P = 0.071). Co-occurrence of diabetes and depression was associated with increased odds of diabetes detection (odds ratio [OR] 1.398, P &lt; 0.001) and treatment (OR 1.344, P &lt; 0.001), but not with higher odds of glycemic control (OR 0.913, P = 0.377).

CONCLUSIONS
In MICs, individuals aged 50 years and older with diabetes and depression showed heightened diabetes identification and treatment probabilities, unlike patterns seen in HICs. This underscores the unique interplay of these conditions in different income settings.
Health Care Utilization and Costs Associated With Empagliflozin in Older Adults With Type 2 Diabetes
Authors: Htoo Phyo Than , NajafZadeh Mehdi , Tesfaye Helen , Schneeweiss Sebastian , Wexler Deborah J. , Glynn Robert J. , Schmedt Niklas , Déruaz-Luyet Anouk , Koeneman Lisette , Paik Julie M. , Patorno Elisabetta 
Published: June 2024

OBJECTIVE
We compared health care resource utilization (HCRU) and costs for inpatient and outpatient services and dispensed medications in older adults with type 2 diabetes initiating empagliflozin versus dipeptidyl peptidase 4 inhibitors (DPP-4is).

RESEARCH DESIGN AND METHODS
The study population included U.S. Medicare fee-for-service beneficiaries with diabetes (age ≥65 years) initiating empagliflozin or DPP-4is (August 2014 to September 2018). We estimated rate ratios (RRs) for HCRU outcomes using zero-inflated negative binomial regression and per-member per-year (PMPY) cost differences using generalized linear model with gamma distributions, overall and stratified by baseline cardiovascular disease (CVD), after adjusting for 143 baseline covariates using 1:1 propensity score matching.

RESULTS
We identified 23,335 matched pairs (mean age 72 years, 51% with baseline CVD). HCRU rates were lower in empagliflozin versus DPP-4i initiators (number of inpatient days, RR 0.89 [95% CI 0.82, 0.97]; number of emergency department [ED] visits, 0.86 [0.82, 0.91]; number of hospitalizations, 0.86 [0.79, 0.93]; number of office visits, 0.96 [0.95, 0.98]). Inpatient cost (−$713 PMPY [95% CI −847, −579), outpatient cost (−$198 PMPY [−272, −124]), and total cost of care (−$1,109 PMPY [−1,478, −739]) were lower for empagliflozin versus DPP-4is, although diabetes medication cost was higher in empagliflozin initiators ($454 PMPY [95% CI 284, 567]). In the CVD subgroup, total cost was lower for empagliflozin initiators (−$2,005 PMPY [−2,451, −1,337]), while the difference was attenuated in the non-CVD subgroup (−$296 PMPY [−740, 148]).

CONCLUSIONS
Among older adults with diabetes, empagliflozin was associated with a lower number of inpatient days, hospitalizations, ED visits, and office visits and with lower costs of care compared with DPP-4is, especially in those with history of CVD.
Assessment of structural and functional changes in recipient's transplanted heart in the long-term postoperative period
Authors: Khubutiya M. Sh. , Alidzhanova Kh. G. , Dyatlov A. V. , Ivannikov A. A. , Shemakin S. Yu. , Kosolapov D. A. 
Published: June 2024

Introduction. Heart transplantation is an effective way of treating patients with end-stage heart failure. Echocardiography allows for the assessment of the transplanted heart functions at all stages of follow-up. The clinical implementation of myocardial deformation imaging by the speckle tracking echocardiography has made it possible to detect subtle changes in myocardial contractility.Objective. To study the structural and functional state of myocardium in recipients in the long term after orthotopic heart transplantation.Material and methods. The study included 13 orthotopic heart transplant recipients (11 men and 2 women) at a mean age of 54.1±9.1 years who underwent orthotopic heart transplantation at the N.V. Sklifosovsky Research Institute for Emergency Medicine. The mean follow-up period after orthotopic heart transplantation was 6±0.7 years. All patients underwent transthoracic echocardiography according to the standard protocol, including determination of left ventricular myocardial deformation.Results. The median volume of the left atrium was 60 (53;76) ml, the left ventricular end-diastolic volume was 76 (70;90) ml, and the end-systolic volume was 30 (24;36) ml. The median ejection fraction of the left ventricle in the studied sample was 64 (57;66)%. The median interventricular septum thickness was 12 (11;13) mm, the left ventricular posterior wall thickness was 9 (8;10) mm. At the same time, the left ventricular myocardial mass and the left ventricular myocardial mass index were within the normal range and amounted to 140 (121;155) g and 65 (58;76) g/m2, respectively. The right heart chambers were not dilated, as the volume of the right atrium was 41 (40;56) ml, and the right ventricular enddiastolic dimension was 32 (30;33) mm. The right ventricular systolic function was unimpaired: the tricuspid annular plane systolic excursion was 18 (17;19) mm, and the right ventricular fractional area change was 46 (37.5;47.0)%. The calculated systolic pulmonary artery pressure was within the normal range 24 (21;28) mm Hg. The measurements of left ventricle global longitudinal and circumferential strains were -19.6 (-18.6;-21.2)% and -30.9 (-28.8;-32.0) %, respectively. Patients in the study sample showed a decrease in the left ventricular global function index to 25 (24.2;29.6)%. The diastolic dysfunction of a restrictive type was present in 10 patients (76.9%).Conclusions. In the long-term period after heart transplantation, the recipients were found to have a low left ventricular ejection fraction and a diastolic dysfunction of the restrictive type. Considering the normal values of left ventricular myocardial strains, we can assume that after 6 years post-orthotopic heart transplantation, the recipients have restored the heart adaptive functions, and a favorable outcome has been achieved. However, long-term monitoring is required.
PENGARUH MODEL PEMBELAJARAN ROTATING TRIO EXCHANGE TERHADAP HASIL BELAJAR SISWA
Authors: Akmal Akmal , Mairizal Mairizal , Zaswita Hermi 
Published: June 2024

Penelitian ini bertujuan untuk mengetahui besarnya pengaruh model pembelajaran Rotating Trio Exchang terhadap hasil belajar siswa pada Mata Pelajaran Geografi Kelas X SMA As-Shofa Pekanbaru. Jenis penelitian ini adalah penelitian Quasi Eksperimen. Subjek dalam penelitian ini adalah siswa kelas X di SMA As-Shofa Pekanbaru sedangkan objeknya adalah pengaruh model pembelajaran Rotating Trio Exchang terhadap hasil belajar siswa pada Mata Pelajaran Geografi Kelas X di SMA As-Shofa Pekanbaru. Sampel yang digunakan dalam penelitian ini adalah siswa kelas X1 dan X2 yang berjumlah 53 siswa. Teknik pengambilan data dilakukan dengan menggunakan observasi, tes dan dokumentasi. Hasil analisa data menunjukan skor rata-rata Pre Test yaitu sebesar 58,33 menjadi 78,51 pada nilai Post test. Jika dihitung presentasi yang diperoleh, maka dapat dilihat besar kenaikan adalah 34,59%.. Dengan demikian, dapat disimpulkan ada pengaruh yang signifikan antara penggunaan model pembelajaran Rotating Trio Exchang terhadap hasil belajar siswa pada Mata Pelajaran Geografi Kelas X SMA As-Shofa Pekanbaru. Kata kunci: Model Pembelajaran, Rotating Trio Exchang, Hasil Belajar
WORD OF MOUTH MARKETING DAN PERSONAL SELLING PADA PENGELOLAAN BRAND AWARENESS BATIK SEMARANGAN DI KAMPUNG BATIK REJOMULYO SEMARANG
Authors: Setyowati Lenny , Pasaribu Rotumiar , Saintio Fidelis Aggiornamento 
Published: June 2024

Kampung Batik Rejomulyo dikenal masyarakat sebagai sentra Batik Semarangan tentu tidak terlepas dari brand awareness masyarakat. Jika seseorang sadar dan tahu akan suatu merek pastinya orang tersebut akan menjadi tertarik dan memiliki niat untuk mencoba membeli suatu merek tersebut. Brand awareness dapat dibentuk melalui Word of Mouth Marketing (WoM) dan personall selling. Tujuan penelitian ini untuk menganalisis marketing communication tools berupa WoM dan kegiatan personal selling yang ditemukan pada pengelolaan brand awareness Batik Semarangan. Jenis penelitian ini adalah kualitatif, menggunakan metode penelitian studi kasus. Pengumpulan data melalui observasi, wawancara dan dokumentasi. Wawancara dilakukan kepada 5 orang narasumber perajin, penjual, pemilik toko Batik Semarangan di Kampung Batik Rejomulyo Semarang dan 6 orang pengunjung yang telah melakukan pembelian. Aktifitas WoM terjadi secara organik oleh konsumen yang pernah berkunjung ke Kampung Batik Rejomulyo. Mereka menceritakan kembali kepada teman, saudara baik secara lisan maupun tertulis melalui pesan di Whatsapp. Word of Mouth Marketing dalam 4 aturannya yaitu be interesting, make it easy, make people happy dan earn trust and respect ditemukan pada penelitian ini. Sumber konsumen menerima WoM dari teman, keluarga, pihak hotel tempat menginap wisatawan sehingga membuat mereka tertarik untuk berkunjung ke Kampung Batik Rejomulyo Semarang. Pembicaraan secara alami terjadi karena konsumen yang pernah berkunjung mengalami, mendapatkan kualitas positif pada saat berkunjung ke Kampung Batik Rejomulyo. 6 tahapan pada personal selling sudah diterapkan yaitu mencari calon pelanggan, pra pendekatan, presentasi dan demonstrasi, mengatasi keberatan, tindak lanjut dan pemeliharaan, serta tahap penutupan. Ada tahap yang belum dilakukan maksimal yaitu pada tahap mencari calon pelanggan karena ada perajin, penjual dan pemilik toko yang belum aktif mencari pelanggan, lebih pada menunggu pengunjung datang ke tokonya. Bentuk pengelolaan brand awareness dilakukan oleh perajin, penjual dan pemilik toko dengan cara menjaga kualitas produk, pelayanan personal dengan memberikan rekomendasi pilihan batik, mengedukasi cara mencuci, menjemur Batik Semarangan dan seni batik. Info produk baru disampaikan kepada konsumen melalui Whatsapps, paket belajar membatik juga ditawarkan kepada pengunjung agar mereka tetap mengingat Batik Semarangan Kampung Batik Rejomulyo.
Responsible Innovation in E-Health Care: Empowering Patients with Emerging Technologies
Authors: Trzmielak Dariusz M. , Lipka-Matusiak Ilona , Oftedal Elin 
Published: June 2024

Abstract
The use of new technologies should create new value for all stakeholders in the healthcare system. This article explores the transformative impact of new technologies in e-health, focusing on enhancing patient empowerment and healthcare delivery. It underscores how artificial intelligence (AI) and other innovative technologies may redefine service standards, expand functionalities, boost clinician knowledge and competencies, and relieve clinicians’ workload, thereby enabling broader and more specialized healthcare services. Through a comparative analysis of technology applications in various medical sectors, the study proposes a new, original classification of new e-health technologies according to benefits to the main healthcare stakeholders – patients, clinicians, and the healthcare system itself. The methodology includes bibliographic research and a study of selected cases of technology implementations, discussing both theoretical and practical implications for medical organizations. The classification of new e-health technologies that we propose herein a clear framework for understanding the various ways in which these innovations can be implemented to maximize their benefits across different sectors of the healthcare industry.
Radiolysis of composite polypropylene/hemp fibers
Authors: Głuszewski Wojciech , Lewandowska Hanna , Malinowski Rafał , Krasinska Oksana 
Published: June 2024

Abstract
This paper presents the results of the research on the effects of ionizing radiation on the properties of a composite material consisting of polypropylene (PP) and hemp fibers (HFs). The radiolysis effects were investigated for the composites having HF contents in the amounts of 10, 20, 30, and 40% by weight, as well as for pure PP. Particular attention was paid to the protective effects the aromatic compounds contained in the HF had on the radiolysis of PP/HF composites. This phenomenon may explain the deviations that the irradiated composites displayed upon the addition of HFs and their dependency on the HF content. Both the granules and the standardized composite specimens were subjected to radiation treatment. The gas chromatography (GC) technique was employed to determine the yield of radiolytically generated hydrogen (GH2) and absorbed oxygen (GO2). The oxidation phenomenon was studied during irradiation, 24 h after irradiation, and after a 40-day aging period at room temperature. Changes in the melt flow rate (MFR) and the mechanical properties were also determined. It was described how the radiation treatment of the investigated composites accelerates their degradation. It was found that this effect applies to both HF and PP. It was also demonstrated that PP not only does not enhance the resistance of HF to oxidation but, on the contrary, accelerates the processes of their post-radiation degradation. It was further observed that the phenomenon of postradiation degradation can be controlled by changing the PP content in the composite, as well as the amount of aromatic compounds present in the HF. The amount of the absorbed dose allows us to control the degradation time of the PP/HF composites. This applies in particular to the chain oxidation of the PP matrix triggered by the ionizing radiation. It was also found that composites based on PP and natural fibers susceptible to radiation degradation may have significant implications for the use of easily degradable polymer materials in the environment.