bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights from utilizing data of different quality levels for simulating barley performance under Nordic conditions: The Agricultural Production Systems SIMulator model evaluation
Authors: Appiah Mercy , Bracho-Mujica Gennady , Svane Simon , Styczen Merete , Kersebaum Kurt-Christian , Rötter Reimund P 
Published: July 2024

Abstract
Crop model-aided ideotyping can accelerate the breeding of resilient barley cultivars. Yet, the accuracy of process descriptions in the crop models still requires substantial improvement, which is only possible with high-quality (HQ) experimental data. Despite being demanded frequently, such data are still rarely available, especially for Northern European barley production. This study is one of the first to contribute to closing this existing data gap through the targeted collection of HQ experimental data in pluri-annual, multi-location spring barley field trials in Denmark. With this data, the prediction accuracy of Agricultural Production Systems SIMulator significantly increased in contrast to commonly utilized lower quality datasets. Using this data for model calibration resulted in more accurate predictions of in-season plant development and important state variables (e.g. final grain yield and biomass). The model’s prediction accuracy can ultimately be further improved by examining remaining model weaknesses that were discoverable with the HQ data. Process descriptions regarding, for example, early and late leaf development, soil water dynamics and respective plant response appeared to require further improvement. By illustrating the effect of data quality on model performance we reinforce the need for more model-guided field experiments.
Use of a commercial feed supplement based on diatom earth and yeast products on oxidative status and in vitro immune response in buffaloes during peripartum
Authors: Maggiolino Aristide , Sgarro Maria Federica , Casalino Elisabetta , Latronico Tiziana , Liuzzi Grazia Maria , De Palo Pasquale 
Published: July 2024

Abstract
The transition period is a critical metabolic phase for dairy ruminants, especially those with high production levels. In spite of this, little is still known about dairy water buffalo. The aim of this study was to evaluate the effect of a commercial feed additive based on diatomaceous earth and hydrolyzed yeasts on health status, milk quality, and immune response of buffalo cows during the transition period. Eighty healthy Water buffaloes (Bubalus bubalis) of Italian Mediterranean breed were included in the trial. They were subdivided into two groups: one group received the additive (n = 40) while the control group (n = 40) received a placebo. The trial lasted 120 d, from 60 d before calving to 60 d in milk. Blood samples were collected from each buffalo at −60 (60 d from the expected calving), −30, 0 (calving), +15, +30, and +60 d (respectively, i.e., 15, 30, and 60 d in milking). The biochemical as well as the oxidative profile, and the antioxidant power and enzymatic activity were evaluated in the samples obtained. Moreover, acute phase proteins, reactive proteins, and interleukin plasma levels were determined. Peripheral blood mononuclear cells (PBMCs) and monocytes were isolated and viability, reactive oxygen species (ROS), and reactive nitrogen species were measured on PBMC and monocytes. The introduction of additives enhanced the total antioxidant capacity and enzyme activity, while no differences were observed in oxidation products throughout the trial. Additionally, it significantly reduced the synthesis of ROS in polymorphonuclear cells, supporting a potential positive response in animals experiencing inflammation. The impact of oxidation on the products was not evident. Despite higher enzyme levels in plasma, this did not necessarily correspond to significantly increased enzymatic activity but rather indicated a higher potential. From these results, it was evident that the transition period in buffaloes differs notably from what reported in the literature for cows, probably due to the absence of common postpartum production diseases in dairy cows and lower metabolic challenges linked to lower milk production in buffaloes. Few parameters exhibited notable changes during the transition period in buffaloes, notably certain antioxidant enzymes, PBMC viability, PBMC ROS production, and Hp levels.
Inspiring or demoralizing? Deservingness perceptions help determine why emerging adults experience positive or negative effects from envy-inducing social media posts
Authors: Montes Enoch , DeAndrea David C 
Published: July 2024

Abstract
This study extends pain-driven dual envy theory to explain why emerging adults who do not attend college might experience uplifting or hostile reactions to the social media posts of their college-attending peers. Employing a 2 × 2 experiment (N = 233; Mage  = 21.87), we examined how deservingness perceptions (deserving versus undeserving) and social approval cues (high versus low) affect the type of envy emerging adults experience from viewing college success posts on social media. Results indicated that the more participants perceived the college success of their peers to be deserved, the more they experienced benign envy. Conversely, the more participants appraised the college success of their peers to be undeserved, the more they experienced malicious envy. Results also indicated that posts with higher social approval indirectly triggered more pain for participants. Overall, findings help clarify why social media users can experience both positive and negative effects from online social comparisons.
The evolution of judicial standards: evidence from litigated merger trials
Authors: Macher Jeffrey T , Mayo John W , Sappington David E M , Whitener Mark 
Published: July 2024

Abstract
A popular narrative suggests that, in the wake of the rise of the Chicago School, the judiciary has grown increasingly lax, making it difficult for antitrust agencies to successfully challenge mergers in court. We develop a theoretical framework to yield propositions regarding merger challenges, settlements, and outcomes under varying judicial standards. We then undertake an empirical investigation of all mergers, challenges, and litigated outcomes in the United States over 1982–2021 to test for the presence of shifting judicial standards. Contrary to the popular narrative, we find evidence that judicial standards have become increasingly pro-enforcement over the past four decades.
Immunomodulatory effects of Yu-Ping-Feng formula on primary Sjögren syndrome: interrogating the T-cell response
Authors: Yu Sulan , Zhou Xinyao , Liu Ruihua , Xu Xiaoyu , Ma Danbao , Feng Yun , Lin Xiang 
Published: July 2024

Abstract
Ethnopharmacological treatments have shown beneficial effects in the clinical practice of autoimmune disorders. However, the underlying mechanism of immunomodulatory effects remains challenging, given the complicate composition of herbal medicines. Here, we developed an immunological approach to interrogate the T helper cell response. Through data mining, we hypothesized that Chinese medicine formula Yu-Ping-Feng might be a promising candidate for treating primary Sjögren syndrome, a common autoimmune disease manifested by exocrine gland dysfunction. We took advantage of a mouse model of experimental Sjögren syndrome that we previously established for Yu-Ping-Feng formula treatment. Yu-Ping-Feng therapy ameliorated the experimental Sjögren syndrome pathology in mice with active disease, showing improved salivary function and decreased serum levels of autoantibodies. Phenotypic analysis suggested that both effector T and B cells were significantly suppressed. Using coculture assay and adoptive transfer models, we demonstrated that Yu-Ping-Feng formula directly restrained effector/memory T-cell expansion and differentiation into Th17 and T follicular helper cells, the key subsets in experimental Sjögren syndrome pathogenesis. Importantly, we recruited 20 patients with primary Sjögren syndrome and conducted a pilot study of 8-wk therapy of Yu-Ping-Feng formula. Yu-Ping-Feng treatment effectively improved fatigue symptoms and exocrine gland functions, as well as reduced serum IgG/IgA levels, while effector T- and B-cell subsets were significantly decreased. There was a trend of reduction on disease activity, but not statistically significant. Together, our findings suggest a novel approach to assess the immunomodulatory effects of Yu-Ping-Feng formula, which may be favorable for patients with autoimmune disorders.
Cancers with epidemiologic signatures of viral oncogenicity among immunocompromised populations in the United States
Authors: Haas Cameron B , Shiels Meredith S , Pfeiffer Ruth M , D’Arcy Monica , Luo Qianlai , Yu Kelly , Austin April A , Cohen Colby , Miller Paige , Morawski Bozena M , Pawlish Karen , Robinson William T , Engels Eric A 
Published: July 2024

Abstract

Background
Immunosuppressed individuals have elevated risk of virus-related cancers. Identifying cancers with elevated risk in people with HIV and solid organ transplant recipients, 2 immunosuppressed populations, may help identify novel etiologic relationships with infectious agents.

Methods
We used 2 linkages of population-based cancer registries with HIV and transplant registries in the United States. Cancer entities were systematically classified according to site and histology codes. Standardized incidence ratios were used to compare risk in people with HIV and solid organ transplant recipients with the general population. For selected cancer entities, incidence rate ratios were calculated for indicators of immunosuppression within each population.

Results
We identified 38 047 cancer cases in solid organ transplant recipients and 53 592 in people with HIV, yielding overall standardized incidence ratios of 1.66 (95% confidence interval [CI] = 1.65 to 1.68) and 1.49 (95% CI = 1.47 to 1.50), respectively. A total of 43 cancer entities met selection criteria, including conjunctival squamous cell carcinoma (people with HIV standardized incidence ratio = 7.1, 95% CI = 5.5 to 9.2; solid organ transplant recipients standardized incidence ratio = 9.4, 95% CI = 6.8 to 12.6). Sebaceous adenocarcinoma was elevated in solid organ transplant recipients (standardized incidence ratio = 16.2, 95% CI = 14.0 to 18.6) and, among solid organ transplant recipients, associated with greater risk in lung and heart transplant recipients compared with recipients of other organs (incidence rate ratio = 2.3, 95% CI = 1.7 to 3.2). Salivary gland tumors, malignant fibrous histiocytoma, and intrahepatic cholangiocarcinoma showed elevated risk in solid organ transplant recipients (standardized incidence ratio = 3.9,  4.7, and  3.2, respectively) but not in people with HIV. However, risks for these cancers were elevated following an AIDS diagnosis among people with HIV (incidence rate ratio = 2.4, 4.3, and  2.0, respectively).

Conclusions
Elevated standardized incidence ratios among solid organ transplant recipients and people with HIV, and associations with immunosuppression within these populations, suggest novel infectious causes for several cancers including conjunctival squamous cell carcinoma, sebaceous adenocarcinoma, salivary gland tumors, malignant fibrous histiocytoma, and intrahepatic cholangiocarcinoma.
TikTok and teen mental health: an analysis of user-generated content and engagement
Authors: Lau Nancy , Srinakarin Kavin , Aalfs Homer , Zhao Xin , Palermo Tonya M 
Published: July 2024

Abstract

Background
TikTok is a social media mobile application that is widely used by adolescents, and has the potential to serve as a revolutionary platform for public and mental health discourse, education, and intervention.

Objective
Our study aimed to describe the content and engagement metrics of the hashtag #teenmentalhealth on TikTok.

Methods
In this study, we: (a) conducted a directed content analysis of the Top 100 TikTok videos tagged with #teenmentalhealth, and (b) collected data on video engagements (views, likes, saves, and shares) and computed view-based engagement rates.

Results
The videos collectively garnered 144,320,591 views; 28,289,655 likes; 219,780 comments; 1,971,492 saves; and 478,696 shares. Most of the generated content were from teens and therapists. Engagement metrics revealed strong user engagement rates across user types. The most prevalent content categories represented across videos were personal experience, coping techniques or treatment, humor, interpersonal relationships, and health campaign. The content categories with the highest engagement rates were relatable media representation, health campaign, social isolation, and humor. Only a single video incorporated evidence-based treatment content.

Conclusion
TikTok facilitates communication and information dissemination on teen mental health. Future research should focus on improving the quality and credibility of digital content while maintaining engagement through creativity, self-expression, and relatability. Use of popular social media platforms and community-engaged research to disseminate evidence-based content may help bridge the translational research gap.
A disc wind origin for the optical spectra of dwarf novae in outburst
Authors: Tampo Yusuke , Knigge Christian , Long Knox S , Matthews James H , Segura Noel Castro 
Published: July 2024

ABSTRACT
Many high-state cataclysmic variables (CVs) exhibit blue-shifted absorption features in their ultraviolet (UV) spectra – a smoking-gun signature of outflows. However, the impact of these outflows on optical spectra remains much more uncertain. During its recent outburst, the eclipsing dwarf nova V455 And displayed strong optical emission lines whose cores were narrower than expected from a Keplerian disc. Here, we explore whether disc + wind models developed for matching UV observations of CVs can also account for these optical spectra. Importantly, V455 And was extremely bright at outburst maximum: the accretion rate implied by fitting the optical continuum with a standard disc model is $\dot{M}_{\rm acc} \simeq 10^{-7}~{\rm M}_\odot ~{\rm yr^{-1}}$. Allowing for continuum reprocessing in the outflow helps to relax this constraint. A disc wind can also broadly reproduce the optical emission lines, but only if the wind is (i) highly mass-loaded, with a mass-loss rate reaching $\dot{M}_{\rm wind} \simeq 0.4 \dot{M}_{\rm acc}$, and/or (ii) clumpy, with a volume filling factor $f_V \simeq 0.1$. The same models can describe the spectral evolution across the outburst, simply by lowering $\dot{M}_{\rm acc}$ and $\dot{M}_{\rm wind}$. Extending these models to lower inclinations and into the UV produces spectra consistent with those observed in face-on high-state CVs. We also find, for the first time in simulations of this type, P-Cygni-like absorption features in the Balmer series, as have been observed in both CVs and X-ray binaries. Overall, dense disc winds provide a promising framework for explaining multiple observational signatures seen in high-state CVs, but theoretical challenges persist.
Chemical evolution models: the role of type Ia supernovae in the α-elements over iron relative abundances and their variations in time and space
Authors: Cavichia O , Mollá M , Bazán J J , Castrillo A , Galbany L , Millán-Irigoyen I , Ascasibar Y , Díaz A I , Monteiro H 
Published: July 2024

ABSTRACT
The role of type Ia supernovae (SN Ia), mainly the delay time distributions (DTDs) determined by the binary systems, and the yields of elements created by different explosion mechanisms, are studied by using the MulChem chemical evolution model applied to our Galaxy. We explored 15 DTDs and 12 tables of elemental yields produced by different SN Ia explosion mechanisms, doing a total of 180 models. Chemical abundances for $\alpha$-elements (O, Mg, Si, and Ca) and Fe derived from these models are compared with recent solar region observational data of $\alpha$-elements over Fe relative abundances, [X/Fe], as a function of [Fe/H] and age. A multidimensional maximum-likelihood analysis shows that 52 models are able to fit all these data sets simultaneously, considering the 1$\sigma$ confidence level. The combination of STROLG1 DTD from Strolger et al. (2020) and LN20181 SN Ia yields from Leung & Nomoto (2018) provides the best fit. The exponential model with very prompt events is a possible DTD, but a combination of several channels is more probable. The SN Ia yields that include MCh or Near MCh correspond to 39 (75 per cent) of the 52 best models. Regarding the DTD, 31 (60 per cent) of the 52 most probable models correspond to the SD scenario, while the remaining 21 (40 per cent) are based on the DD scenario. Our results also show that the relatively large dispersion of the observational data may be explained by the stellar migration from other radial regions, and/or perhaps a combination of DTDs and explosion channels.
Unravelling jet quenching criteria across L* galaxies and massive cluster ellipticals
Authors: Su Kung-Yi , Bryan Greg L , Hayward Christopher C , Somerville Rachel S , Hopkins Philip F , Emami Razieh , Faucher-Giguère Claude-André , Quataert Eliot , Ponnada Sam B , Fielding Drummond , Kereš Dušan 
Published: July 2024

ABSTRACT
In the absence of supplementary heat, the radiative cooling of halo gas around massive galaxies (Milky Way mass and above) leads to an excess of cold gas or stars beyond observed levels. Active galactic nucleus jet-induced heating is likely essential, but the specific properties of the jets remain unclear. Our previous work concludes from simulations of a halo with $10^{14} \,\mathrm{ M}_\odot$ that a successful jet model should have an energy flux comparable to the free-fall energy flux at the cooling radius and should inflate a sufficiently wide cocoon with a long enough cooling time. In this paper, we investigate three jet modes with constant fluxes satisfying the criteria, including high-temperature thermal jets, cosmic ray (CR)-dominant jets, and widely precessing kinetic jets in $10^{12}-10^{15}\, {\rm M}_{\odot }$ haloes using high-resolution, non-cosmological magnetohydrodynamic simulations with the FIRE-2 (Feedback In Realistic Environments) stellar feedback model, conduction, and viscosity. We find that scaling the jet energy according to the free-fall energy at the cooling radius can successfully suppress the cooling flows and quench galaxies without violating observational constraints. On the contrary, if we scale the energy flux based on the total cooling rate within the cooling radius, strong interstellar medium cooling dominates this scaling, resulting in a jet flux exceeding what is needed. Among the three jet types, the CR-dominant jet is most effective in suppressing cooling flows across all surveyed halo masses due to enhanced CR pressure support. We confirm that the criteria for a successful jet model work across a wider range, encompassing halo masses of $10^{12}-10^{15} {\rm M_\odot }$.
The infall region as a complementary probe to cluster abundance
Authors: Mpetha C T , Taylor J E , Amoura Y , Haggar R 
Published: July 2024

ABSTRACT
Galaxy cluster abundance measurements provide a classic test of cosmology. They are most sensitive to the evolved amplitude of fluctuations, usually expressed as $S_8 = \sigma _8\sqrt{\Omega _{\rm m}/0.3}$. Thus, abundance constraints exhibit a strong degeneracy between $\sigma _8$ and $\Omega _{\rm m}$, as do other similar low-redshift tests such as cosmic shear. The mass distribution in the infall region around galaxy clusters, where material is being accreted from the surrounding field, also exhibits a cosmological dependence, but in this case it is nearly orthogonal to the $S_8$ direction in the $\Omega _{\rm m}$–$\sigma _8$ plane, making it highly complementary to halo abundance or cosmic shear studies. We explore how weak-lensing measurements of the infall region might be used to complement abundance studies, considering three different tests. The splashback radius is a prominent feature of the infall region; we show that detection of this feature in lensing data from the Euclid survey could independently constrain $\Omega _{\rm m}$ and $\sigma _8$ to $\pm 0.05$. Another feature, the depletion radius where the bias reaches a minimum, also shows cosmological dependence, though it is challenging to observe in practice. The strongest constraints come from direct measurements of the shear profile in the infall region at 2–$4\, r_{200{\rm c}}$. Combining the latter with abundance constraints such as those reported from SRG$/$eROSITA should reduce the area of the error contours by an estimated factor of 1.2 using a sample of clusters observed by the UNIONS survey, or a factor of 3 using clusters observed by the Euclid Wide survey over a broader range of redshift.
Rewinding the Ratchet: Rare Recombination Locally Rescues Neo-W Degeneration and Generates Plateaus of Sex-Chromosome Divergence
Authors: Decroly Thomas , Vila Roger , Lohse Konrad , Mackintosh Alexander 
Published: July 2024

Abstract
Natural selection is less efficient in the absence of recombination. As a result, nonrecombining sequences, such as sex chromosomes, tend to degenerate over time. Although the outcomes of recombination arrest are typically observed after many millions of generations, recent neo-sex chromosomes can give insight into the early stages of this process. Here, we investigate the evolution of neo-sex chromosomes in the Spanish marbled white butterfly, Melanargia ines, where a Z-autosome fusion has turned the homologous autosome into a nonrecombining neo-W chromosome. We show that these neo-sex chromosomes are likely limited to the Iberian population of M. ines, and that they arose around the time when this population split from North-African populations, around 1.5 million years ago. Recombination arrest of the neo-W chromosome has led to an excess of premature stop-codons and frame-shift mutations, and reduced gene expression compared to the neo-Z chromosome. Surprisingly, we identified two regions of ∼1 Mb at one end of the neo-W that are both less diverged from the neo-Z and less degraded than the rest of the chromosome, suggesting a history of rare but repeated genetic exchange between the two neo-sex chromosomes. These plateaus of neo-sex chromosome divergence suggest that neo-W degradation can be locally reversed by rare recombination between neo-W and neo-Z chromosomes.
Symmetry breaking of fluorophore binding to a G-quadruplex generates an RNA aptamer with picomolar KD
Authors: Lu Xiaocen , Passalacqua Luiz F M , Nodwell Matthew , Kong Kristen Y S , Caballero-García Guillermo , Dolgosheina Elena V , Ferré-D’Amaré Adrian R , Britton Robert , Unrau Peter J 
Published: July 2024

Abstract
Fluorogenic RNA aptamer tags with high affinity enable RNA purification and imaging. The G-quadruplex (G4) based Mango (M) series of aptamers were selected to bind a thiazole orange based (TO1-Biotin) ligand. Using a chemical biology and reselection approach, we have produced a MII.2 aptamer–ligand complex with a remarkable set of properties: Its unprecedented KD of 45 pM, formaldehyde resistance (8% v/v), temperature stability and ligand photo-recycling properties are all unusual to find simultaneously within a small RNA tag. Crystal structures demonstrate how MII.2, which differs from MII by a single A23U mutation, and modification of the TO1-Biotin ligand to TO1-6A-Biotin achieves these results. MII binds TO1-Biotin heterogeneously via a G4 surface that is surrounded by a stadium of five adenosines. Breaking this pseudo-rotational symmetry results in a highly cooperative and homogeneous ligand binding pocket: A22 of the G4 stadium stacks on the G4 binding surface while the TO1-6A-Biotin ligand completely fills the remaining three quadrants of the G4 ligand binding face. Similar optimization attempts with MIII.1, which already binds TO1-Biotin in a homogeneous manner, did not produce such marked improvements. We use the novel features of the MII.2 complex to demonstrate a powerful optically-based RNA purification system.