bluuebunny/crossref_metadata_2025_split huggingface dataset:
Which Capital Flow Surge Methods Are Better at Predicting Reversals and Sudden Stops?: Balancing Type 1 and Type 2 Errors
Authors: Choi Yongseok , Efremidze Levan , Sula Ozan , Willett Thomas D. 
Published: July 2024

AbstractCapital flow surges have become a major source of concern as they have been often followed by disruptive reversals and sudden stops. We introduce F-score methodology which evaluates how well particular capital flow surge method can predict reversals and sudden stops. F-scores consider both type 1 and type 2 errors and provide policy makers a framework to weigh economic costs of false negative and false positive signals. We construct and compare a large number of commonly used surge identification approaches, including several machine-learning methods, to investigate which types of formulations best help explain which surges are more likely to be reversed. While considerable literature has investigated the determinants of capital flow reversals and sudden stops with surges being included as one of the independent variables, so far little research attention has been focused directly on attempting to determine the likelihood that particular surge will result in reversals or sudden stops. This is the most important question for policies toward capital inflows since the optimal responses to capital flow surges would be quite different depending on whether the flows are likely to be reversed or not. Unfortunately, theory does not offer a clear guide to identifying surges other than that they are unusually large inflows. We emphasize that appropriate evaluation should involve not only precision in predicting reversals but also accuracy in not giving false alarms by predicting reversals that do not occur. In other words, attention needs to be paid to both type 1 and type 2 errors.
Temperature Dependence of Viscoelasticity of Lubricating Oil with Adsorptive Polymer Additives Sheared in Nanogaps
Authors: Nozue Takumi , Itoh Shintaro , Okubo Naoya , Fukuzawa Kenji , Zhang Hedong , Azuma Naoki 
Published: July 2024

AbstractAdsorptive polymer additives have been reported to improve the retention capacity of oil films under hydrodynamic lubrication and to reduce friction under boundary lubrication. These effects are believed to result from the formation of a polymer adsorption film on the surface that acts as a lubricious coating. Polymer adsorption films have become dominant in nanometer-order microscopic gaps. However, their mechanical properties are difficult to quantify. This hinders the development of polymer additives. In our previous study, we successfully measured the shear viscoelasticity of lubricants (base oils) sheared in nanogaps using an originally developed measurement method called the fiber wobbling method (FWM). In this study, we measured the shear viscoelasticity of polymer-added lubricants in nanogaps by using FWM. In addition, we developed a heating stage in the FWM to quantify the temperature dependence of shear viscoelasticity in nanogaps. As a result, the viscosity index improved and elasticity was observed in the nanogap, where the polymer adsorption film was dominant. Furthermore, our results indicated that the elasticity of the adsorbed polymer film originated from entropic elasticity.
Graphical Abstract
Cardiac autonomic function in REM-related obstructive sleep apnoea: insights from nocturnal heart rate variability profiles
Authors: Ucak Seren , Dissanayake Hasthi U. , Sutherland Kate , Yee Brendon J. , Kairaitis Kristina , Wheatley John R. , Piper Amanda J. , de Chazal Philip , Cistulli Peter A. ,   on behalf of the Sydney Sleep Biobank Investigators, Sarkissian Nina , Bin Yu Sun , Chow Chin Moi , Chan Andrew , Lowth Aimee , Graham Jacob , Wood William , Cohen Gary , Bennett Callum , Ahmadi Mohammad , Yee Brendon , Piper Amanda , Wong Keith , Melehan Kerri , Chan Margaret , Wang David , Gauthier Gislaine 
Published: July 2024

Abstract
Purpose
In light of the reported association between REM-related obstructive sleep apnoea (OSA) and heightened cardiovascular risk, this study aims to compare cardiac autonomic function in patients with REM-OSA and OSA independent of sleep stage. We hypothesized that REM-OSA patients would exhibit higher sympathetic cardiac modulation based on heart rate variability (HRV) profiles.

Methods
HRV was compared between the OSA group (AHI ≥ 5 events/h, n = 252) and the REM-OSA group (AHI ≥ 5 events/h, AHIREM:AHINREM ≥ 2, n = 137). Time- and frequency-domain measures of HRV were analysed during N2 and REM sleep.

Results
Clinical characteristics between the two test groups differed significantly, 45% of REM-OSA patients were female, with mild OSA (median, interquartile range (IQR)) AHI of 10 (7) events/h. Only 26% of the OSA cohort were female with moderate OSA (AHI = 17 (20) events/h, p < 0.001). Compared with the OSA group, the low frequency to high frequency ratio (LF:HF) and LF power were lower and HF power was higher in the REM-OSA group during N2 (LF:HF, p = 0.012; LF; p = 0.013; HF, p = 0.007) and in REM sleep (LF:HF, p = 0.002; LF, p = 0.004; HF, p < 0.001). Patient sex and OSA severity had a significant combined effect on average N to N interval, LF power, and LF:HF ratio during N2 and REM sleep (all p < 0.001).

Conclusion
Contrary to our hypothesis, REM-OSA patients demonstrated consistently higher cardiac vagal modulation, reflecting better cardiac autonomic adaptation. These results were attributed to differences in OSA severity and sex in these two groups, both independently affecting HRV. This study emphasises the need for future research into the underlying pathophysiology of REM-OSA and the potential implications of sex and OSA severity on cardiovascular risk.
CT colonography has advantages over colonoscopy for size measurement of colorectal polyps
Authors: Tsurumaru Daisuke , Nishimuta Yusuke , Nanjo Katsuya , Kai Satohiro , Miyasaka Mitsutoshi , Muraki Toshio , Ishigami Kousei 
Published: July 2024

Abstract
Purpose
The aim of this study was to compare the accuracy of colonoscopy (CS) and CT colonography (CTC) in the measurement of colorectal polyps using pathological size as a reference.

Materials and methods
The analysis included 61 colorectal polyps in 28 patients who underwent preoperative CTC at our institution. All polyps were endoscopically resected. Polyp sizes were measured by CS and CTC. Endoscopic polyp size was extracted from endoscopy records written by one of two endoscopists (A with 11 and B with 6 years of endoscopic experience, respectively), who estimated the size visually/categorically without any measuring devices. After matching the location, the polyp size was measured on CTC using manual three-dimensional (3D) measurement on a workstation. The sizes of resected polyps were also measured after pathological inspection. Differences of the polyp size between CTC and histology, and between CS and histology were compared using paired t tests. Differences in measurement between the two endoscopists were also analyzed.

Results
The mean diameters of polyps measured using CS, CTC, and pathology were 10.5 mm, 9.2 mm, and 8.4 mm, respectively. There was a significant correlation between CS and pathology, as well as between CTC and pathology (both P < 0.0001). The correlation coefficient for CS (r = 0.86) was lower than that for CTC (r = 0.96). The correlations between CS and pathology for endoscopists A and B were 0.90 and 0.89, respectively.

Conclusion
Measurements of polyp size using CTC were closer to the pathological measurements compared to those by CS, which exhibited greater variability. This suggests that CTC may be more suitable for polyp size measurements in the clinical setting if patients undergo CTC concurrently with colonoscopy.
Exploring the Experiences of Family Caregivers in the Management of Stroke Among the Older Adults in Nigeria: A Qualitative Study
Authors: Farombi Temitope H. , Khan Hafiz T. A. , Lawal Muili 
Published: July 2024

AbstractStroke, a significant neurological condition, often results in stroke survivors who are older adults relying on family caregivers, including children and spouses, leading to increased challenges for caregivers. This study investigates the experiences of family caregivers caring for stroke survivors who are older adults, focusing on the context of stroke management. Participants were purposively sampled, and three focus group discussions involving family caregivers (n = 18) of older adults who had experienced strokes were conducted. Conversations were recorded, translated, transcribed, and subjected to thematic analysis utilizing NVivo (version 12 pro) software. Thematic analysis yielded five distinct themes. The first theme illuminated family caregivers’ insights regarding the management of stroke in their members or significant others. The second theme emphasized the support and information received at the medical facility. The third theme showcased the perceived value of the information provided. The fourth theme highlighted unmet needs for both information and training in social support. The final theme illuminated the participants’ preferences for how they would like to receive information and training. This study highlights family caregivers’ experiences, encompassing a range of burdens, stresses, and challenges while caring for stroke survivors who are older adults. Findings emphasize the necessity for formal caregivers to provide adequate information, support, and training to family caregivers, thereby alleviating their burdens and enhancing stroke management in a home environment.
Advancing mental health predictions through sleep posture analysis: a stacking ensemble learning approach
Authors: Nouman Muhammad , Khoo Sui Yang , Mahmud M. A. Parvez , Kouzani Abbas Z. 
Published: July 2024

AbstractSleep posture is closely related to sleep quality, and can offer insights into an individual’s health. This correlation can potentially aid in the early detection of mental health disorders such as depression and anxiety. Current research focuses on embedding pressure sensors in bedsheets, attaching accelerometers on a subject’s chest, and installing cameras in bedrooms for sleep posture monitoring. However, such solutions sacrifice either the user's sleep comfort or privacy. This study explores the effectiveness of using contactless ultra-wideband (UWB) sensors for sleep posture monitoring. We employed a UWB dataset that is composed of the measurements from 12 volunteers during sleep. A stacking ensemble learning method is introduced for the monitoring of sleep postural transitions, which constitute two levels of learning. At the base-learner level, six transfer learning models (VGG16, ResNet50V2, MobileNet50V2, DenseNet121, VGG19, and ResNet101V2) are trained on the training dataset for initial predictions. Then, the logistic regression is employed as a meta-learner which is trained on the predictions gained from the base-learner to obtain final sleep postural transitions. In addition, a sleep posture monitoring algorithm is presented that can give accurate statistics of total sleep postural transitions. Extensive experiments are conducted, achieving the highest accuracy rate of 86.7% for the classification of sleep postural transitions. Moreover, time-series data augmentation is employed, which improves the accuracy by 13%. The privacy-preserving sleep monitoring solution presented in this paper holds promise for applications in mental health research.
Change in Mindfulness Profiles After Mindfulness-Based Cognitive Therapy for Major Depressive Disorder
Authors: Lubbers Jelle , Spinhoven Philip , Cladder-Micus Mira B. , Spijker Jan , Speckens Anne E. M. , Geurts Dirk E. M. 
Published: July 2024

Abstract
Objectives
Mindfulness-Based Cognitive Therapy (MBCT) reduces recurrence and current depressive symptoms in patients with major depressive disorder (MDD). To understand how and for whom MBCT works, a person-centered approach focusing on mindfulness profiles can be useful. Four mindfulness profiles, each associated differently with mental health outcomes, have previously been identified. So far, no studies have examined whether profiles change after MBCT and whether these changes are related to treatment outcome.

Method
Latent transition analysis (LTA) was performed on pre- and post-MBCT subscale scores of the Five Facet Mindfulness Questionnaire (FFMQ) in patients with current or remitted MDD (n=500). LTA allowed the assessment of individual changes in mindfulness profile after MBCT and the relation between profile change and corresponding changes in measures of mental health, including depressive symptoms, overall functional impairment, worry, and self-compassion.

Results
LTA re-established the four profiles previously identified cross-sectionally: “Very low mindfulness” (VLM), “Non-judgmentally aware” (NJA), “Judgmentally observing” (JO), and “High mindfulness” (HM). For 71 out of 168 patients with VLM profiles changed to NJA and for another 30 to HM. For 49 out of the 129 patients with NJA and for 37 out of 141 patients with JO profiles changed to HM. All 61 patients starting with HM kept HM. In general, change was related to greater than average improvement in mental health, while no change in profile was related to less than average improvement in mental health (except for HM).

Conclusions
Our findings indicate that changes in mindfulness profile after MBCT was differentially related to clinical change. These results from a person-centered approach offer new avenues to further elucidate the working mechanism of MBCT and improve its outcome.

Preregistration
This study was not preregistered.
The structures control the evolution of molasse basins and alteration zones occurrences in the northwestern sector of the Central Eastern Desert of Egypt
Authors: Abd El-Wahed Mohamed A. , Kassem Osama M. K. , Abudeif Abdelbaset M. , Abdelhameed Mohammed , Attia Mohamed 
Published: July 2024

AbstractIntegration between the analyses of both fieldwork and remote sensing dataset were employed to assess the structural evolution of molasse basins and explore gold mineral deposits in the El Qash area, Central Eastern Desert of Egypt. Sandstone, mudstones, wacke, and pebbly conglomerates make up most of the sediments in the molasse basins. The younger basins (595–575 Ma) are small, less weathered, and mostly Dokhan detritus-filled basins compared to the larger older basins (> 625–605 Ma), which have more weathered sources mainly of arc metavolcanics. The molasse basins appear to have originated in a north–south regional extensional setting, characterized by a prolonged period of left-lateral transtension combined with the formation of NNE-trending synformal folds during an ENE–WSW compression phase. Notably, en-echelon arrays of normal faults, oriented perpendicular to the boundary of the strike-slip shear zone, are a recurring feature in basins formed through transtension. Furthermore, oblique NE-SW compression played a role in generating SW-dipping thrust faults and regional folding with NW–SE orientation, along with the reactivation of transtensional normal faults in a reverse manner. Multispectral satellite imagery data and radar data are used to map the relevant lithological units, structures, and hydrothermal alteration zones. This study concludes that the regions where gold deposits may be explored in connection with prospecting alteration minerals include the area around the ophiolitic assemblages, and the granitic intrusions, in addition to the felsite and the molasse sediments contacts.
Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions
Authors: Xian Gaopeng , Huang Rong , Xu Minhui , Zhao Hengli , Xu Xingbo , Chen Yangchao , Ren Hao , Xu Dingli , Zeng Qingchun 
Published: July 2024

AbstractCalcific aortic valve disease (CAVD) is becoming an increasingly important global medical problem, but effective pharmacological treatments are lacking. Noncoding RNAs play a pivotal role in the progression of cardiovascular diseases, but their relationship with CAVD remains unclear. Sequencing data revealed differential expression of many noncoding RNAs in normal and calcified aortic valves, with significant differences in circHIPK3 and miR-182-5p expression. Overexpression of circHIPK3 ameliorated aortic valve lesions in a CAVD mouse model. In vitro experiments demonstrated that circHIPK3 inhibits the osteogenic response of aortic valve interstitial cells. Mechanistically, DEAD-box helicase 5 (DDX5) recruits methyltransferase 3 (METTL3) to promote the N6-methyladenosine (m6A) modification of circHIPK3. Furthermore, m6A-modified circHIPK3 increases the stability of Kremen1 (Krm1) mRNA, and Krm1 is a negative regulator of the Wnt/β-catenin pathway. Additionally, miR-182-5p suppresses the expression of Dickkopf2 (Dkk2), the ligand of Krm1, and attenuates the Krm1-mediated inhibition of Wnt signaling. Activation of the Wnt signaling pathway significantly contributes to the promotion of aortic valve calcification. Our study describes the role of the Krm1-Dkk2 axis in inhibiting Wnt signaling in aortic valves and suggests that noncoding RNAs are upstream regulators of this process.
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders
Authors: Ramachandran Rajath , Manan Abdul , Kim Jei , Choi Sangdun 
Published: July 2024

AbstractProinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory response, which is essential for the proper functioning of our immune system. When infections or threats to the body’s defense mechanisms are detected, the innate immune system takes the lead. However, an excessive inflammatory response can lead to the production of high concentrations of cytotoxic molecules, resulting in tissue damage. Inflammasomes are significant contributors to innate immunity, and one of the most extensively studied inflammasome complexes is NOD-like receptor 3 (NLRP3). NLRP3 has a wide range of recognition mechanisms that streamline immune activation and eliminate pathogens. These cytosolic multiprotein complexes are composed of effector, adaptor, and sensor proteins, which are crucial for identifying intracellular bacterial breakdown products and initiating an innate immune cascade. To understand the diverse behavior of NLRP3 activation and its significance in the development of lifestyle-related diseases, one must delve into the study of the immune response and apoptosis mediated by the release of proinflammatory cytokines. In this review, we briefly explore the immune response in the context of lifestyle associated disorders such as obesity, hyperlipidemia, diabetes, chronic respiratory disease, oral disease, and cardiovascular disease.
Genome-resolved metagenomics: a game changer for microbiome medicine
Authors: Kim Nayeon , Ma Junyeong , Kim Wonjong , Kim Jungyeon , Belenky Peter , Lee Insuk 
Published: July 2024

AbstractRecent substantial evidence implicating commensal bacteria in human diseases has given rise to a new domain in biomedical research: microbiome medicine. This emerging field aims to understand and leverage the human microbiota and derivative molecules for disease prevention and treatment. Despite the complex and hierarchical organization of this ecosystem, most research over the years has relied on 16S amplicon sequencing, a legacy of bacterial phylogeny and taxonomy. Although advanced sequencing technologies have enabled cost-effective analysis of entire microbiota, translating the relatively short nucleotide information into the functional and taxonomic organization of the microbiome has posed challenges until recently. In the last decade, genome-resolved metagenomics, which aims to reconstruct microbial genomes directly from whole-metagenome sequencing data, has made significant strides and continues to unveil the mysteries of various human-associated microbial communities. There has been a rapid increase in the volume of whole metagenome sequencing data and in the compilation of novel metagenome-assembled genomes and protein sequences in public depositories. This review provides an overview of the capabilities and methods of genome-resolved metagenomics for studying the human microbiome, with a focus on investigating the prokaryotic microbiota of the human gut. Just as decoding the human genome and its variations marked the beginning of the genomic medicine era, unraveling the genomes of commensal microbes and their sequence variations is ushering us into the era of microbiome medicine. Genome-resolved metagenomics stands as a pivotal tool in this transition and can accelerate our journey toward achieving these scientific and medical milestones.
MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
Authors: Lee Dong-Joon , Kim Pyunggang , Kim Hyun-Yi , Park Jinah , Lee Seung-Jun , An Haein , Heo Jin Sun , Lee Min-Jung , Ohshima Hayato , Mizuno Seiya , Takahashi Satoru , Jung Han-Sung , Kim Seong-Jin 
Published: July 2024

AbstractThe asymmetric division of stem cells permits the maintenance of the cell population and differentiation for harmonious progress. Developing mouse incisors allows inspection of the role of the stem cell niche to provide specific insights into essential developmental phases. Microtubule-associated serine/threonine kinase family member 4 (Mast4) knockout (KO) mice showed abnormal incisor development with low hardness, as the size of the apical bud was decreased and preameloblasts were shifted to the apical side, resulting in amelogenesis imperfecta. In addition, Mast4 KO incisors showed abnormal enamel maturation, and stem cell maintenance was inhibited as amelogenesis was accelerated with Wnt signal downregulation. Distal-Less Homeobox 3 (DLX3), a critical factor in tooth amelogenesis, is considered to be responsible for the development of amelogenesis imperfecta in humans. MAST4 directly binds to DLX3 and induces phosphorylation at three residues within the nuclear localization site (NLS) that promotes the nuclear translocation of DLX3. MAST4-mediated phosphorylation of DLX3 ultimately controls the transcription of DLX3 target genes, which are carbonic anhydrase and ion transporter genes involved in the pH regulation process during ameloblast maturation. Taken together, our data reveal a novel role for MAST4 as a critical regulator of the entire amelogenesis process through its control of Wnt signaling and DLX3 transcriptional activity.