bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of bronchial arterial chemoembolization (BACE) in combination with tislelizumab for non-small cell lung cancer (NSCLC): A phase II study.
Authors: Duan Xuhua , Li Hao , Kuang Donglin , Zhang Mengfan , Xu Wenze , Liang Chao , Wang Jiacheng , Han Daqian , Ren Jianzhuang 
Published: June 2024

8609 Background: Bronchial artery chemoembolization (BACE) and immune checkpoint inhibitors (ICIs) are important therapy for NSCLC. The short-term benefit from BACE is considerable while the long-term survival benefits from ICIs is remarkable. This trial is designed to determine the efficacy and safety of immunotherapy with tislelizumab in addition to BACE in stage III-Ⅳ NSCLC patients (pts) who failed, refused or ineligible to receive standard treatments. Methods: In a single-arm, phase II study (NCT05058560), stage III-IV NSCLC patients who refused or were ineligible to receive standard treatments were enrolled. Patients received BACE followed by 200 mg tislelizumab every 3 weeks until disease progression, intolerable toxicities, or discontinuation determined by the investigators. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were overall survival (OS), objective response rate (ORR), disease control rate (DCR), safety, and quality of life (QoL). Results: Thirty patients were enrolled in this study between December 2021 and August 2022. The median follow-up was 12 (range, 1.5-12) months. At the data cutoff (August 31, 2023), the median PFS was 10.5 (95% confidence interval [CI], 7.8-13.2) months and the median OS was not reached. The 3 -, 6 -, and 12-month ORR were 63.3% (95%CI, 43.9%-80.1%), 56.7% (95%CI, 37.4%-74.5%), and 30.4% (95%CI, 13.2%-52.9%), respectively. The DCR at 3 months was 80% (95%CI, 61.4%-92.3%), at 6 months was 76.7% (95%CI, 57.7%-90.1%), and at 12 months was 47.8% (95%CI, 26.8%-69.4%). The expression rate of PD-L1, tumor feeding arteries, and the application times of tislelizumab were prognostic factors for PFS. No grade 3 or higher treatment-related adverse events (TRAEs) occurred. Common grade 2 TRAEs were nausea, fever, and cough. QoL improved significantly after 1 cycle of treatment compared with baseline, including global quality of life, physical functioning, and emotional functioning. Conclusions: The study demonstrated promising efficacy and manageable safety profiles of BACE plus tislelizumab for advanced NSCLC patients, indicating a potential and effective treatment option for this population. Clinical trial information: NCT05058560 .
Factors influencing career choices and post-fellowship perspectives in adult hematology/oncology physicians: A nationwide cross-sectional study.
Authors: Gonzalez Mosquera Luis , Balanchivadze Nino , Ali Faria , Meranda Matthew , Hinojosa Castro Oscar , Kuriakose Philip 
Published: June 2024

9015 Background: We aimed to investigate the timing and influence of factors behind career choices in hematology and medical oncology, assess levels of job satisfaction, and identify factors contributing to professional retention and the prevention of attrition. Methods: An anonymous survey with 13 questions was distributed to practicing hematologists and oncologists who were members of the American Society of Clinical Oncology and/or American Society of Hematology. The respondents encompassed diverse areas of primary focus within the field, varied practice settings, and all geographical regions. Results: Out of 423 respondents, 66% were male and 32% female. The majority identified as White (69%), followed by Asian (19%), Middle Eastern (4%), Hispanic (3%), and Black (1%). Most were practicing either Medical Oncology (43%) or combined Hematology/Oncology (36%), with 46% working in an academic/university setting and 57% located in an urban region. In terms of timing, about a third had decided on their career choice in medical school, with the majority of the remaining having decided by residency. While most of those surveyed were practicing in the area they had hoped to, about one-sixth (17.5%) appeared to be working in an area they hadn't planned on. Most said they would choose their current profession again (67% definitely yes, 24% likely yes). Science and academic interest (81%) ranked the highest when combining the top two responses for factors influencing choice, followed by mentor influence (47%), with work/life balance (19%) and financial considerations (6%) being less frequently cited. Satisfaction levels were generally high across key dimensions (Table), with intellectual fulfillment receiving the highest satisfaction (63.1% very satisfied, 26% satisfied). Importantly, better work/life balance (37% respondents), fewer non-medical tasks (35%), and a higher salary (20%) were key considerations to deter professional attrition. Conclusions: This study offers valuable insights into the career perspectives of Hematologists and Medical Oncologists, providing a foundation for developing strategies for career development and retention initiatives within the specialty. Efforts should be undertaken to enhance participation from different minorities within Hematology/Oncology and physicians practicing Classical Hematology to identify specific support and retention needs for these areas. [Table: see text]
Formation and evaluation of the ASCO medical education community of practice (Med Ed CoP).
Authors: Brondfield Sam , Manochakian Rami , Walsh Katherine Jean , Baggstrom Maria Quintos , Henry Elizabeth , Parikh Aparna Raj , Rangachari Deepa , Barry Maura Meredith , Gao Jennifer , Giuliani Meredith Elana , Im Annie P. , Marrone Kristen A. , McNamara Mairead Geraldine , Murphy Martina Cathryn , Rosenstein Lori J , Russell Brian , Tseng Jennifer , Schwartz Jennifer E. 
Published: June 2024

9022 Background: High quality education is crucial for hematology/oncology (H/O) training and lifelong learning. However, H/O has historically prioritized clinical and research careers over medical education careers. Consequently, few programs support H/O educators. A CoP is a group that shares “a concern or passion for something they do and learn how to do it better as they interact regularly.” We formed the ASCO Med Ed CoP in 2021 to provide a collaborative network and professional development venue for H/O educators. Methods: Following a published framework for developing a global health professions educator community (Establish-Grow-Sustain), we (ASCO Education Scholars Program graduates) developed CoP mission and vision statements and a leadership structure (Establish), formed committees and projects (Grow), and gathered at the ASCO Annual Meeting and via virtual Town Halls (Sustain). In 2023, we collected demographics and evaluated the CoP using a logic model focused on inputs, activities, outputs, and impact. Results: As of December 2023, the CoP includes 238 members from 143 institutions (38 [27%] non-U.S.): 207 (87%) ASCO members; 127 (53%) women, 106 (45%) men, 5 (2%) no response (NR); 111 (47%) White, 88 (37%) Asian/Pacific Islander, 27 (11%) Latinx/Hispanic, 12 (5%) Black/African-American, 8 (3%) Middle Eastern, 1 (0.4%) African, 16 (7%) NR; 146 (61%) hematologist/oncologists, 68 (29%) trainees, 6 (3%) radiation oncologists, 3 (1%) surgical oncologists, and 15 (6%) other professionals. The logic model is displayed (Table). Conclusions: The CoP has had an impact on its members, ASCO, and beyond and continues to grow and sustain itself by recruiting broadly, driving projects forward, and making structural adjustments for long-term sustainability. Upcoming projects include providing more educational resources and measuring outcomes such as changes in members’ knowledge, skills, and attitudes. Membership diversity continues to be a challenge and a priority. [Table: see text]
Practice makes perfect: Using simulation to build and assess competency in bone marrow biopsy for heme/onc fellows.
Authors: Rosenstein Lori J. 
Published: June 2024

9042 Background: The American Board of Internal Medicine (ABIM) requires that Hematology/Oncology fellows demonstrate competence in bone marrow biopsies (BMB). However, offers no guidance in assessment methods. Neither the "see one, do one, teach one" nor the "complete 5 procedures" approach is sufficient to ensure competency. As this is a potentially painful procedure that requires knowledge of landmarks, simulation in a safe environment is an ideal way to introduce BMB to trainees. In 2015, we started a simulation program to teach fellows how to perform BMB using a cadaver pelvis, and assess their BMB competency. Methods: The Hematology Oncology Fellowship Program at Gundersen Health System holds a half-day simulation for our 6 fellows each July. We begin with a self-evaluation of current skills, using an 8-question pre-test. We then view a demonstration video, pausing to discuss key learning points. Fellows are given a detailed check list of the steps of the procedure. They then experiment with the tools of the procedure and practice sterile technique. We discuss the indications, contraindications, consent, and the procedure itself. For part two, fellows are divided into two groups, each consisting of a first year (F1), second year (F2), and third year (F3) fellow. A cadaver pelvis is used as the model and is positioned in a prone position. Each team is assigned a side of the pelvis. The F3 demonstrates the procedure from start to finish while the F2 and staff assesses competency and the F1 follows with the procedure check list. Once the F3 has completed the procedure and is deemed "competent" they become the leader of the session for their team. F1s can practice as many times as desired, under the guidance of the F2 and F3. F2s also have a chance to refine their skills. After the simulation is complete, fellows repeat the self-evaluation, and we debrief. Results: 44 fellows completed the simulation (F1=16, F2=14, F3=14). Questions for the pre- and post-tests were ranked on a 5-point Likert Scale of strongly agree (1) to strongly disagree (5). F1s had the worst self-assessment prior to the procedure, with a mean score of 2.4 for all questions. However, their post-test self-assessment improved to 1.6. F2s started at 1.5 and improved to 1.1 after the simulation. F3s started at 1.2 and improved to 1.0. All fellows answered that this was a useful exercise and should be continued. Comments were consistently positive, speaking to the importance of a check list, the relaxed atmosphere, and having senior fellows teach the junior fellows. Conclusions: BMB simulation allows for a low-stakes introduction to a stressful procedure, while promoting a team approach to learning. It also gives an opportunity to verify competence for graduating fellows. Fellows self-reported improvement following the session as well as from year to year. Fellows value this learning experience and look forward to it each year.
Analysis of hematology-oncology fellowship match outcomes (2007-2022) and cross-subspecialty comparisons: A retrospective cohort study.
Authors: Ingawale Sushrut , Abbagoni Vaidarshi , Verma Abhiroop , Regelmann David , Kollipara Praveen 
Published: June 2024

9044 Background: The four most sought-after fellowships following Internal Medicine, by volume, are: Hematology-Oncology (HO), Cardiovascular (CV), Gastroenterology (GI), and Pulmonology-Critical Care (PC). This analysis assesses the trends in match outcomes for HO compared to other fellowships, including subset National Residency Match Program (NRMP) outcomes based on applicant types [United States (US) and non-US medical graduates (MDs)]. Methods: This retrospective cohort study analyzes applicants who applied to HO, CV, GI, or PC fellowships for 2007-2022. The analysis is based on publicly available NRMP data for this time. Metrics analyzed include: number of applicants per position, number and type of applicants, number and type of successfully matched applicants, and, corresponding match rates (MR) within each subspecialty. Using the chi-square test, this analysis compared match outcomes between different applicant types. Results: Out of total 55,604 applicants, the distribution across subspecialties was as follows: HO (12,006), CV (19,950), GI (11,693), and PC (11,955). Despite the apparent differences in the total number of applicants for different subspecialties, the number of applicants per position was not statistically significantly different, and decreased from 2007 to 2022 for all subspecialties except PC (+6.7%). As the number of applicants increased, the number of available positions also increased to a substantially higher degree. In 2008, MR ranged from 50-64% across subspecialties, gradually increasing over the years, with HO achieving the highest MR at 73.5% in 2022, compared to PC at 60.7%. USMD graduates consistently had higher MRs compared to non-USMDs (p<0.001) across all subspecialties. Despite this persistent gap over the study's duration, this difference progressively narrowed across all subspecialties, with HO representing the lowest difference (22.1%) and GI the highest (37.2%) in match rates for 2022. Conclusions: The HO fellowship exhibited the highest match rates, closely followed by CV. The proportional increase in HO, CV and GI positions in response to the growing applicants has led to a reduction in the applicants per position, unlike in PC. HO fellowship consistently stands out with the lowest MR disparity among USMDs and non-USMDs. This may represent successful efforts towards equity, diversity and inclusion among programs. [Table: see text]
Hematology/oncology fellowship programs’ instagram presence.
Authors: Greenberg Max , Ssentongo Paddy , Mattikalli Shivani , Tomasulo Emily , Desai Parth Anil , Perimbeti Stuthi , Komiya Takefumi , Rakszawski Kevin 
Published: June 2024

9047 Background: Since the SARS-CoV-2 pandemic, applicants and programs have transitioned to virtual platforms as a surrogate for in-person visits. Social media provides insight into trainees’ experiences, wellness, medical education, and life outside the hospital. Instagram has been reported as the preferred platform and a majority of applicants note that social media content could change their perception of a program.1 Due to the emergence of social media in fellowship recruitment, no studies have analyzed the relationship between Instagram content and hematology/oncology fellowship programs’ perception. Methods: The American Medical Association Fellowship and Residency Electronic Interactive Database was used to identify and categorize programs as either community-based (CB), community-based academic affiliated (CBAA), university-based (UB), military, and other. For programs with Instagram pages created prior to 2023, the posts from 2022 were subjectively classified into one of two categorizes, either “Medical Education” or “Fellow Life” based on the emphasis of the caption and image. “Medical Education” encompassed posts that promote education as well as academic accomplishments of trainees and faculty. “Fellow Life” included posts emphasizing culture, wellbeing, camaraderie, and social activities. Post from 2023 were analyzed for Instagram accounts created after 2022. The first image was used for posts containing multiple images. This was exempt from IRB review by Pennsylvania State University. Results: There are 183 accredited hematology/oncology fellowships programs; 60% (n=110) UB, 28% (n=52) CBAA, 9% (n=16) CB, 2% (n=4) others, and 0.5% (n=1) military. Of the 183 programs, 33 Instagram pages representing 18% of programs were identified (binomial test, p<0.0001), consisting of 70% (n=23) UB, 24% (n=8) CBAA, and 6% (n=2) CB. UB programs were significantly more likely to have an Instagram (Fisher’s exact test p<0.0001). Posts highlighting “Fellow Life” were significantly more frequent than those emphasizing “Medical Education” (Wilcoxon signed rank test, p = 0.001) (interquartile range: 65% (50-84%) vs. 36% (17-50%)). Conclusions: Despite the implementation of virtual interviews, an overwhelming majority of hematology/oncology fellowship programs do not have an Instagram page. Those with Instagram emphasize extracurricular wellbeing and culture, which is likely valuable to applicants. In this digital age, Instagram is not just a platform; it is a catalyst for connection, engagement, and decision-making in the hematology/oncology recruitment landscape. We advocate for a strategic embrace of Instagram, a balanced content mix highlighting academic and cultural facets, as a key recruitment strategy, reflecting the unique ethos of each program. Reference: 1. Oliver MG, Kelly K: Student Perceptions and Use of Social Media as Residency Program Information. Fam Med 54:380–383, 2022.
Realism’s Reputations, Financialized Whiteness
Authors: Huerta Monica 
Published: June 2024

Abstract
This essay uses the legal rearticulation of reputation as white heteropatriarchal property in an “Imperial Jim Crow” United States to piece apart the preoccupation with characters’ reputations in realist fiction. It focuses on two later-nineteenth-century arenas of what property theorist and legal scholar K-Sue Park has called the “generative dynamics” of racial capitalism: new markets in private commercial credit and the socio-legal (re)production of reputation. In so doing, the essay unearths realism’s invisiblized generic presupposition that the idea of reputations that help create modern literary characters are a neutral or self-evident category of experience.
Water Troubles: Peruvian Capitalists, Mining Infrastructure, and the First Copper Bonanza
Authors: Rubio Juan Manuel 
Published: June 2024

Abstract
This essay examines struggles over a water drainage tunnel as a window into the politics of mining, infrastructure, and national development in early twentieth-century Peru. It argues that the Peruvian mining elite operated as an organized network of entrepreneurs, mobilizing capital, environmental technology, and the power of the state to challenge the rising hegemony of US interests in Peru's copper corridor. Unlike the classic literature on nineteenth-century mining in Peru, which has presented Peruvian mineowners as a struggling bourgeoisie, this study focuses on this group's innovations and dynamism in the wake of the copper bonanza. It also studies its discursive strategies, which appealed to preexisting skepticism of free trade and anxieties about foreign influence. Altogether, this essay contributes to the literature on US imperialism and capitalist penetration by centering local actors and studying US hegemony as a contentious and contingent process.
Manuscript and the Human in Modern China
Authors: Estep Chloe 
Published: June 2024

Abstract
While the stylus, or handwriting instrument, is typically left out of narratives of technologization, this article details how manuscripts expressed modernity. By examining representations of pens and brushes in print media and cinema from the Republican and socialist eras, this article shows that the stylus served as a metonym for the changing status of the human in manuscript writing in the modern period. While earlier literary examples show that the brush and the human were understood to be commensurable, mutually resonant categories, rapid technological and political changes in the twentieth century led to increasing friction between the human and various forms of manuscript writing. This reevaluation of the relationship between writer and writing instrument began in the early twentieth century and resulted in anxiety over the introduction of mechanized forms of inscription into a human-centered writing process. Examples from Maoist cinema in the latter half of the twentieth century show the replacement of this anxiety with attempts to integrate manuscript writing into socialist modernity through the displacement of the writing subject.
Diagnostic value of multimodal cardiovascular imaging technology coupled with biomarker detection in elderly patients with coronary heart disease
Authors: Liu Xiaocheng , Li Yong , Li Weitian , Zhang Youtao , Zhang Shaolei , Ma Yongqing , Yang Fei , Zhu Yuexiang 
Published: June 2024

Aims/Background Coronary heart disease is a common disease in the elderly and has a complex pathogenesis, which complicates the clinical diagnostic process. Thus, enhancing the diagnostic efficiency for coronary heart disease is imperative to improve the life expectancy of the elderly. This study aimed to explore the diagnostic value of multimodal cardiovascular imaging technology coupled with biomarker detection in elderly patients with coronary heart disease. Methods The medical records of 421 patients with suspected coronary heart disease obtained from the geriatric department of the First Affiliated Hospital of Hebei North University from February 2020 to February 2023 were retrospectively analysed. After excluding 10 patients who did not meet the inclusion criteria, the remaining 411 patients were included in this study. The included subjects had undergone coronary computed tomography angiography and were divided into coronary heart disease group (n=208) and non-coronary heart disease group (n=203) according to the diagnostic results. Multimodal cardiovascular imaging (coronary computed tomography angiography and echocardiography) and detection of serum biomarkers such as small dense low-density lipoprotein, lipoprotein a, and gamma-glutamyl transferase were performed in both groups. The clinical indicators of the two groups were compared, and the combined diagnostic efficacy of multimodal cardiovascular imaging and biomarker detection was evaluated. Results Compared to the non-coronary heart disease group, the coronary heart disease group had significantly higher levels of maximum area stenosis, total plaque volume, total plaque burden and fibrotic plaque volume (p < ..001), and lower left ventricular ejection fraction level (p < ..001). Additionally, the coronary heart disease group exhibited higher levels of left ventricular end-diastolic volume, left ventricular end-systolic volume and stroke volume than the non-coronary heart disease group (p < ..001), and had higher levels of small dense low-density lipoprotein, lipoprotein a and gamma-glutamyl transferase (p < ..001). Our results demonstrated that combined diagnosis had better diagnostic efficacy than individual approaches, marked by higher area under the curve and sensitivity of the former (p < ..001). Conclusion Multimodal cardiovascular imaging technology combined with biomarker detection can distinctly improve the accuracy of coronary heart disease diagnosis in elderly patients.
Family Support of Older Caregivers: Factors Influencing Change in Quality of Life
Authors: Samuel Preethy Sarah , Marsack-Topolewski Christina N. , Janks Elizabeth , Raoufi Gelareh , Milberger Sharon 
Published: June 2024

Abstract
Understanding factors that can improve the quality of life (QOL) of older caregivers of people with intellectual and developmental disabilities (IDD) is important in broadening participation in family empowerment interventions. The purpose of this study was to identify the factors influencing the QOL of older caregivers (50+) of adults with IDD who participated in a peer-mediated state-wide family support project. The research study used a quasi-experimental research design grounded in the family quality of life (FQOL) framework, with pretest and posttest data gathered from 82 caregivers. Correlation and regression analyses were conducted to identify factors influencing changes in the QOL of study participants. Findings indicated that improvements in caregiver QOL after participating in the project could be explained by caregiver’s employment status, increased global FQOL, and decreased caregiver stress and depression.