bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Evaluation of Single Fixed Dosing and Weight‐Based Dosing of Rasburicase for Tumor Lysis Syndrome
Authors: McBride Ali , Lathon Sherrie C. , Boehmer Leigh , Augustin Kristan M. , Butler Sara K. , Westervelt Peter 
Published: March 2013

Study ObjectiveTo evaluate single fixed dosing versus weight‐based dosing strategies for rasburicase to determine the minimum dose required to mitigate hyperuricemia in the treatment or prevention of tumor lysis syndrome.DesignRetrospective medical record reviewSettingAcademic medical centerPatientsA total of 373 patients with a diagnosis of a hematologic malignancy or solid tumor and who received at least one dose of rasburicase over a 6‐year period between January 1, 2005, and February 18, 2011; 180 patients received single doses of 3 mg (38 patients), 6 mg (99 patients), or 7.5 mg (43 patients), and 193 patients received weight‐based dosing.Measurements and Main ResultsTumor lysis syndrome laboratory data were recorded at baseline and monitored up to 72 hours after initial rasburicase administration. Median baseline plasma uric acid levels were 6.85 mg/dl, 8.80 mg/dl, 8.00 mg/dl, and 9.20 mg/dl, respectively, in the 3‐mg, 6‐mg, 7.5‐mg, and weight‐based dosing groups. Treatment success was defined as a normalized plasma uric acid level (< 7.5 mg/dl) within 24 hours after receiving rasburicase. The mean weight‐based dose was 0.16 mg/kg. Six rasburicase treatment failures occurred; two were in the 3‐mg group, one was in the 6‐mg group, and three were in the weight‐based dosing group. At 24 hours after rasburicase administration, no statistically significant differences in treatment success were noted among groups (92.9% vs 97.6% vs 100.0% vs 98.0% in the 3‐mg, 6‐mg, 7.5‐mg, and weight‐based dosing groups, respectively, p=0.1238).ConclusionThe efficacy of all single fixed doses and weight‐based dosing strategies evaluated in this study appear to be comparable in normalizing plasma uric acid levels within 24 hours of rasburicase administration. Although use of a 3‐mg rasburicase dose may be the most cost‐effective treatment strategy in managing hyperuricemia secondary to tumor lysis syndrome, the 6‐mg dose resulted in lower sustained uric acid levels after rasburicase administration. Further analysis of patient specific factors contributing to the need for repeat rasburicase administration should be conducted in larger, prospective clinical trials.
Pharmacokinetics and Pharmacodynamics of Atazanavir‐containing Antiretroviral Regimens, with or without Ritonavir, in Patients who are HIV‐positive and Treatment‐naïve
Authors: Bertz Richard J. , Persson Anna , Chung Ellen , Zhu Li , Zhang Jenny , McGrath Donnie , Grasela Dennis 
Published: March 2013

Study ObjectiveTo investigate the pharmacokinetic and pharmacodynamic relationships of the human immunodeficiency virus (HIV)–protease inhibitor atazanavir (ATV) in the presence and absence of the pharmacokinetic booster ritonavir, utilizing ATV plasma trough concentrations (Ctrough) and clinical biomarkers of antiviral efficacy and safety over 48 weeks.DesignRandomized, open‐label, multicenter, study designed to compare the efficacy and safety of ATV 300 mg plus ritonavir 100 mg (ATV300/r) with that of ATV 400 mg (ATV400).SettingThirty clinic sites across 10 countries in Africa, Europe, North America, and South America.PatientsPatients who were HIV‐positive and treatment‐naïve.InterventionsRandomized to once‐daily ATV400 (105 patients) or ATV300/r (95 patients) plus lamivudine and extended‐release stavudine.Measurements and Main ResultsThe Ctrough approximately 24 hours after the prior unobserved dose was measured through week 48. Composite Ctrough (i.e., the geometric mean of all trough concentrations over the 48 weeks), population inhibitory quotient ([IQ], i.e., Ctrough divided population estimated protein binding adjusted effective concentration at 90% [EC90, 14 ng/ml]), composite population IQ (i.e., ATV composite trough divided by population estimated protein binding adjusted EC90), HIV RNA, CD4 cell counts, and metabolic and safety parameters were also assessed. For ATV400 and ATV300/r, respectively, geometric mean composite Ctrough (CV%) were 127 (106) ng/ml and 670 (63) ng/ml, geometric mean composite population IQ were 9 and 48, and composite Ctrough values of HIV EC90 or more were achieved in 98% and 100% of patients. High ATV Ctrough was associated with low HIV RNA at week 48; however, 88% of patients had HIV RNA less than 400 copies/ml in the lowest composite Ctrough quartile. There was no clear relationship between ATV Ctrough and changes in CD4 cell count. Increases in total bilirubin or jaundice were associated with higher Ctrough. Modest increases in triglycerides and cholesterol were associated with the addition of ritonavir.ConclusionATV‐containing regimens with or without ritonavir achieved ATV exposures that provide robust antiretroviral efficacy and acceptable tolerability in treatment‐naïve patients.
Life‐Threatening Hypoglycemia Associated with Intentional Insulin Ingestion
Authors: Svingos Robert S. , Fernandez Erica M. , Reeder Don N. , Parker John J. 
Published: March 2013

There are reports of insulin overdose by injection, yet little is known regarding the potential harms of intentional oral ingestion of insulin. In this report, we describe a case of massive insulin ingestion and ensuing hypoglycemia. To our knowledge, there are no previously published cases of hypoglycemia caused by intentional insulin ingestion. A 51‐year‐old man intentionally ingested three 10‐ml vials (total of 3000 units) of various insulins: one vial each of insulin aspart, lispro, and glargine. Four symptomatic hypoglycemic episodes, with blood glucose levels of 48, 25, 34, and 40 mg/dl, occurred approximately 1, 3, 4, and 5 hours, respectively, after ingestion. The hypoglycemia could not be explained other than the ingestion of the insulins. The patient was admitted for observation, and euglycemia occurred within 24 hours without any additional hypoglycemic episodes. Hypoglycemia treatment is reviewed in this case report, and factors that may affect systemic response of orally ingested insulin, including gastrointestinal absorption and insulin sensitivity, are discussed. In addition, the findings of our case report may provide useful insight into the development of novel oral insulin products that are currently in research. Despite poor bioavailability (1%) when taken orally, insulin may produce symptomatic hypoglycemia with a massive ingestion. Vigilant blood glucose monitoring, supportive care with glucose replacement therapy, and admission to the hospital for observation may be required.
Nanoassemblies with light‐responsive size and density from linear flexible polyelectrolytes
Authors: Moldenhauer Daniel , Gröhn Franziska 
Published: March 2013

AbstractThis study presents electrostatically self‐assembled nanoparticles from linear flexible polyelectrolytes (poly(diallyldimethylammonium chloride or quarternized poly(4‐vinylpyridine)) and an ionic photo‐isomerizable azo dye (Acid Yellow 38) that can change their size upon UV‐light irradiation. Assemblies with narrow size distribution are stable in aqueous solution. For samples with under‐stoichiometric dye load, UV‐light exposure triggers a size decrease, e.g. from a hydrodynamic radius of Rh = 94 nm to Rh = 62 nm for an Ay38‐PDADMAC sample with a charge ratio of lcharge = 0.7. Size changes are caused by trans‐cis isomerization of the dye, accompanied by a change in hydrophilicity, binding enthalpy and entropy. Assemblies are characterized by static and dynamic light scattering, atomic force microscopy, UV–vis spectroscopy and isothermal titration calorimetry. Zeta potential measurements give insight into the electrostatic stabilization and size‐control of the ionic nano‐assemblies, revealing a master curve of effective surface charge density versus hydrodynamic radius. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys., 2013
Functional peptides for capacitative detection of Ca2+ ions
Authors: Hitzbleck Martina , Vu Xuan Thang , Ingebrandt Sven , Offenhäusser Andreas , Mayer Dirk 
Published: March 2013

AbstractMolecular recognition is the key feature of bioinspired sensor applications. A profound understanding of recognitive binding events is crucial for the design of highly specific and effective binding molecules. In this paper a series of simple to complex oligopeptides, derived from the Ca2+ chelator ethylenediaminetetraacetic acid (EDTA) and the Ca2+ binding protein calmodulin, were investigated. It was shown, that specifically designed oligopeptides can fulfil protein‐like recognition functions but are much easier to immobilize and enable high functional integration. Impedance spectroscopy (IS) could be used to detect binding of Ca2+ to different peptides because the double layer capacitance is highly sensitive to changes in the morphology and dielectric properties of adsorbate layers. Finally, the designed functional oligopeptides were implemented in silicon nanowire field effect transistors (SiNW FETs) as a proof of concept for future problem‐optimized molecules in sensor devices. The graph shows frequency‐normalized admittance plots and corresponding schemes of a peptide monolayers layer before and after binding of Ca2+ ions.
Dielectric spectroscopy study of hydrogen treated lead zirconate titanate (Pb (Zr,Ti)O3)
Authors: Shafiei A. , Troczynski T. 
Published: March 2013

AbstractDielectric spectroscopy technique is used in this work to study the structural changes inside lead zirconate titanate (Pb (Zr,Ti)O3 or PZT) exposed to hydrogen for 24 h at 550 °C, at constant pressure p = 0.13 bar. The results show that even after hydrogen treatment, there are still spontaneous dipoles (TiO or ZrO) inside the PZT. However, the dielectric constant is only about half of that of the as‐received sample. After the hydrogen treatment, two relaxation peaks were observed in the dissipation factor curves. While the kinetics of one of the relaxation peaks obeys the classical Arrhenius law, the other peak shows a non‐monotonic relaxation kinetics. Possible reasons for the formation of these peaks have been discussed.
MOF‐FF – A flexible first‐principles derived force field for metal‐organic frameworks
Authors: Bureekaew Sareeya , Amirjalayer Saeed , Tafipolsky Maxim , Spickermann Christian , Roy Tapta Kanchan , Schmid Rochus 
Published: March 2013

AbstractIn this contribution the development, definition and selected applications of a new force field (FF) for metal‐organic frameworks MOF‐FF is presented. MOF‐FF is fully flexible and is parameterized in a systematic and consistent fashion from first principles reference data. It can be used for a variety of different MOF‐families and in particular – due to the reparametrization of a variety of organic linkers – also to explore isoreticular series of systems. The history of the development, leading to the final definition of MOF‐FF is reviewed along with the application of the previous incarnations of the FF. In addition, the parametrization approach is explained in a tutorial fashion. The currently parametrized set of inorganic building blocks is constantly extended. magnified image
Formate models of currently covered inorganic building blocks.
The processing of electron density profiles from the Mars Express MARSIS topside sounder
Authors: Morgan D. D. , Witasse O. , Nielsen E. , Gurnett D. A. , Duru F. , Kirchner D. L. 
Published: March 2013

AbstractWe here present a manual for the reduction of data from ionograms obtained from the Mars Express MARSIS Active Ionospheric Sounding topside radar sounder. Sample data are presented with the procedure for processing them explained as simply as possible. We discuss the uncertainties inherent in the measurements as well as systematic problems with the data. A sample code is included to facilitate the inversion process. We also include a comparison with an electron density profile taken from the Mars Express Radio Science occultation experiment, showing agreement between the two methods, although the data are not simultaneous.
Fluency Idol: Using Pop Culture to Engage Students and Boost Fluency Skills
Authors: Calo Kristine M. , Woolard‐Ferguson Taylor , Koitz Ellen 
Published: March 2013

AbstractThis article shares an oral reading practice that develops children's fluency skills, with a particular emphasis on performance reading and prosody. The authors share their experiences with Fluency Idol! as a way to engage young children by tapping into pop culture. The practice emphasizes repeated readings, feedback, practice, and performance while encouraging children to read aloud to one another. Applications to a second grade classroom as well as in a college reading clinic are discussed.
Common Core, Commonplaces, and Community in Teaching Reading
Authors: Roskos Kathleen , Neuman Susan B. 
Published: March 2013

AbstractJoseph Schwab, a curriculum theorist, described four commonplaces, or universals, of teaching: content, students, milieu and teachers. This article considers how the Reading Standards of the ELA‐CCSS are shaping these commonplaces in the teaching of reading. The organization of the Reading Standards, for example, focuses on two broad grade bands, K‐5; 6‐12 and its framework outlines curriculum content in three categories, foundations, literacy and informational reading. As a core set of expectations, the Reading Standards challenge learners of all ages and require a more participatory literacy environment. They ask more of beginning teachers who must set a brisk pace in reading instruction if students are to achieve expectations. The importance of community in building strong reading programs that meet high core standards is emphasized. New teachers are strongly encouraged to become actively involved in the implementation of core Reading Standards in their local professional communities.
Living Inquiry: Learning From and About Informational Texts in a Second‐Grade Classroom
Authors: Maloch Beth , Horsey Michelle 
Published: March 2013

AbstractThis article tells the story of one second grade teacher and the ways she integrated informational texts into her classroom. Reported by the classroom teacher and a researcher who studied her practice for a year, the manuscripts details the ways Michelle (the classroom teacher) embedded informational texts in her classroom primarily within the context of inquiry. The two authors first report on the ways Michelle integrated informational texts across the school day and school year, and then present in more detail one inquiry unit on habitats. The authors conclude by arguing that that learning about informational texts is most productive when embedded within inquiry‐focused classrooms engaged in learning from informational texts.
Severe left heart obstruction with retrograde arch flow influences fetal cerebral and placental blood flow
Authors: Yamamoto Y. , Khoo N. S. , Brooks P. A. , Savard W. , Hirose A. , Hornberger L. K. 
Published: March 2013

ABSTRACTObjectiveDecreased middle cerebral artery (MCA) pulsatility index (PI) is a marker of fetal brain‐sparing in placental insufficiency and it is also found in fetuses with severe congenital heart disease. This study sought to explore the impact of anatomical subtypes in fetal heart disease on MCA‐PI and head growth.MethodsWe retrospectively reviewed fetal echocardiograms of pregnancies complicated by fetal hypoplastic left heart syndrome (HLHS; n = 42) with and without anatomic coarctation (n = 28 and n = 10, respectively), isolated severe aortic coarctation (n = 21), D‐transposition of the great arteries (TGA; n = 11) and pulmonary outflow tract obstruction without forward flow across the pulmonary valve (POTO; n = 15), comparing observations with gestational age‐matched controls (n = 89). No fetus had major extracardiac pathology or aneuploidy. MCA and umbilical artery (UA) PI, the cerebral placental ratio (CPR  =  MCA‐PI/ UA‐PI) and neonatal head circumference were obtained and expressed as Z‐scores.ResultsLower MCA‐PI, higher UA‐PI and lower CPR were observed in fetal HLHS and isolated coarctation with reversed arch flow (n = 6) (P < 0.001) but not TGA, POTO or isolated coarctation with antegrade arch flow (n = 15) compared with controls. No difference was found between HLHS with anatomical coarctation and those without; however, MCA‐PI correlated positively with neonatal head circumference in HLHS with reversed distal arch flow (r = 0.33, P < 0.05).ConclusionsSevere left heart obstruction with reversed aortic arch flow is associated with altered fetal cerebral blood flow, and in these conditions, MCA‐PI positively correlates with head growth. Anatomical arch obstruction itself may not be a contributing factor to altered MCA flow in fetal HLHS. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.
Horizontal spatial correlation of hydraulic and reactive transport parameters as related to hierarchical sedimentary architecture at the Borden research site
Authors: Ritzi R. W. , Huang L. , Ramanathan R. , Allen‐King R. M. 
Published: March 2013

Key Points
auto and cross correlation have a common correlation structure
correlation structure is defined by hierarchical sedimentary architecture
stratal lengths at different scales define correlation substructures
Assimilation of stream discharge for flood forecasting: The benefits of accounting for routing time lags
Authors: Li Yuan , Ryu Dongryeol , Western Andrew W. , Wang Q. J. 
Published: March 2013

Key Points
EnKF overcorrects soil moisture in catchment models as it ignores the time lag
EnKS gives better forecasts when routing is not directly updated
EnKS and EnKF gives equivalent results when routing is updated
Early and Late Presentations of Graft Arterial Pseudoaneurysm Following Pancreatic Transplantation
Authors: Lubezky Nir , Goykhman Yaacov , Nakache Richard , Kessler Ada , Baruch Roni , Katz Paulina , Kori Itzhak , Klausner Joseph M. , Ben‐Haim Menahem 
Published: March 2013

AbstractBackgroundGraft pseudoaneurysm (PSA) following pancreatic transplantation (PT) is a rarely reported complication that has significant morbidity and mortality. Few case reports and small series of this complication exist.MethodsRetrospective review of files of 106 patients who underwent PT at the Tel‐Aviv Sourasky Medical center between 1995 and 2010. Accessible asymptomatic patients (n = 35) were referred for graft PSA screening using ultrasound‐Doppler.ResultsEight patients developed graft PSA (8 %). All had early posttransplant sepsis. PSA incidence among patients who had perioperative sepsis is 13 %. Three patients developed early postoperative PSA, presenting as massive abdominal bleeding requiring urgent laparotomy and graft resection. Five patients were diagnosed with late‐onset graft PSA between 3 months and 11 years posttransplant: clinical presentations were massive gastrointestinal bleeding (n = 2), acute renal failure (n = 1), and asymptomatic finding on screening ultrasound‐Doppler (n = 2, 6 % of screened patients).ConclusionsPSA following PT occurs in 8 % of patients. Perioperative infection is a risk factor. Early PSAs present as massive intra‐abdominal bleeding. PSA may develop years posttransplant, may be asymptomatic, but late rupture is possible and presents as gastrointestinal bleeding. We recommend screening of patients at risk with ultrasound Doppler for early detection and treatment of asymptomatic PSAs.
The Bernese peri-acetabular osteotomy through a modified approach. A technical note
Authors: Whittingham-Jones Paul , Kirit Patel Nirav , Hashemi-Nejad Aresh 
Published: March 2013

Introduction A modification of the technique for performing the Bernese periacetabular osteotomy is described. Materials and methods A medial approach to the Ischium and a subtle re-orientation of the pubic osteotomy are detailed. Conclusion Surgical morbidity is likely decreased with a concurrent cosmetic advantage without compromise to surgical correction or patient safety.
A conceptual-driven survey on future internet requirements, technologies, and challenges
Authors: Alberti Antonio Marcos 
Published: March 2013

Abstract
Nowadays, research initiatives to redesign the Internet are popping up around the world. Each of these projects has a particular focus and its own set of design requirements and key technologies. The panorama shows a wide diversity of pre-requirements and arguments, some very specific and superficial, others more general and deep. Despite this diversity, a conceptual-driven analysis of such scenario could reveal the current state-of-the-art on future Internet research, the common aspects that permeate all initiatives, and the open issues to be addressed in future work. This paper provides a comprehensive overview of the contemporary research from an abstract point of view, covering the design requirements and ingredients that are being adopted, interrelating, and analyzing them.
Spectrum of group cohomology and support varieties
Authors: Friedlander Eric M. 
Published: March 2013

AbstractWe give a brief introduction to two fundamental papers by Daniel Quillen appearing in the Annals, 1971. These papers established the foundations of equivariant cohomology and gave a qualitative description of the cohomology of an arbitrary finite group. We briefly describe some of the influence of these seminal papers in the study of cohomology and representations of finite groups, restricted Lie algebras, and related structures.
Saproxylic community, guild and species responses to varying pheromone components of a pine bark beetle
Authors: Etxebeste Iñaki , Lencina José L. , Pajares Juan 
Published: March 2013

AbstractSome bark beetle species (Coleoptera: Scolytinae) produce aggregation pheromones that allow coordinated attack on their conifer hosts. As a new saproxylic habitat is founded, an assemblage of associated beetles kairomonally respond to bark beetle infochemicals. Ips sexdentatus is one of the major damaging insects of Pinus spp. in Southern Europe. Its response to varying ipsenol (Ie) percentages in relation to ipsdienol (Id) was studied in northwestern Spain, along with the entire saproxylic beetle assemblage captured at multiple-funnel traps. Response profile modeling was undertaken for I.sexdentatus sexes and sex-ratios, associated species and for selected trophic groups using a reference Gaussian model. In addition, the effects on the saproxylic assemblages were analyzed. I. sexdentatus response curve peaked at 22.7% Ie content, while remaining taxa that could be modeled, peaked above ca. 40% Ie. Predator guilds showed a linear relationship with Ie proportion, while competitors showed a delayed response peak. Consequently, species assemblages differed markedly between varying pheromone component mixtures. Given that the evaluated pheromonal proportions mimicked that of logs being colonized by I. sexdentatus, results suggested that the registered differential responses at different levels might provide I.sexdentatus with a temporal window that maximizes conspecific attraction while reducing interference with competitor and predatory guilds. Described responses might help improve the monitoring of the population status of target bark beetles and their associates, but also point toward the by-catch of many natural enemies, as well as rare saproxylic beetle species, interfering with the aims of sustainable forest management.
Topological structure of fractal squares
Authors: LAU KA–SING , LUO JUN JASON , RAO HUI 
Published: March 2013

AbstractGiven an integer n ≥ 2 and a digit set ⊊ {0,1,. . .,n − 1}2, there is a self-similar set F ⊂ ℝ2 satisfying the set equation: F=(F+)/n. We call such F a fractal square. By studying a periodic extension H= F + ℤ2, we classify F into three types according to their topological properties. We also provide some simple criteria for such classification.