bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prick testing with chemicals in the diagnosis of occupational contact urticaria and respiratory diseases
Authors: Helaskoski Eva , Suojalehto Hille , Kuuliala Outi , Aalto‐Korte Kristiina 
Published: October 2014

SummaryBackgroundLittle is known about the use of prick tests with chemicals in diagnosing occupational diseases.ObjectiveTo evaluate the use of prick tests in the diagnosis of occupational contact urticaria, asthma and rhinitis caused by chemicals (undertaken at theFinnishInstitute ofOccupationalHealth).Material and methodsWe retrospectively reviewed the patient and test files for the period 1January 1991 to 31May 2011. Prick tests were performed with chemical solutions and human serum albumin (HSA)–chemical conjugates.ResultsPositive prick test reactions to isocyanate–HSAconjugates were associated with isocyanate‐specificIgEin all 20 patients, and 17 patients had a relevant occupational disease. Positive reactions to chloramine‐T–HSAconjugates in 10 patients also indicated the presence of specificIgE, although occupational diseases were not always diagnosed. Eleven of 17 patients with positive reactions to persulfate solutions were diagnosed with an occupational disease. Methacrylates, colophonium‐related substances, amine hardeners, ethanolamines, glutaraldehyde, glyoxal, pyrocatechol and ammonium thioglycolate did not elicit any relevant prick test reactions. No generalized reactions were detected.ConclusionPrick tests can be safely used for diagnosing contact urticaria, asthma and rhinitis caused by isocyanates, chloramine‐T, persulfates, and chlorhexidine, but the results should be carefully interpreted and related to clinical symptoms and other diagnostic tests.
Tuberculous Pericarditis Mimicking a Pericardial Tumor
Authors: Komorovsky Roman , Slaba Ulyana , Smiyan Svitlana 
Published: October 2014

Mini‐AbstractThe image and the clinical message focus on an unusual presentation of tuberculous pericardial involvement appearing as a loculated organized pericardial effusion mimicking a pericardial tumor. Antituberculous combination therapy resulted in complete resolution of the pericardial mass. To the best of our knowledge, such presentation of tuberculous pericarditis has not been previously reported.
Application of Intravascular Ultrasound in the Emergency Diagnosis and Treatment of Patients with ST‐Segment Elevation Myocardial Infarction
Authors: Wang Hong‐Xia , Dong Ping‐Shuan , Li Zhi‐Juan , Wang Hong‐Lei , Wang Ke , Liu Xiang‐Yong 
Published: October 2014

PurposeThis study aimed to examine the application of intravascular ultrasound (IVUS) in ST‐segment elevation myocardial infarction (STEMI) patients with high thrombus burden (thrombus grade ≥3) undergoing emergency diagnosis and primary percutaneous coronary intervention.MethodsEighty STEMI patients were enrolled and randomly assigned to the IVUS‐guided group (38 patients) or non‐IVUS group (42 patients). Stent implantation was performed in non‐IVUS group patients. IVUS group patients were further divided into low‐risk and high‐risk patients on the basis of IVUS evaluation for determining whether stenting should be performed. Major adverse cardiac event (MACE) rates, changes in the left ventricular end‐diastolic diameter (LVEDD) and ejection fraction (EF) values, and stent numbers were examined during hospitalization, and follow‐up was performed at 1, 3, 6, and 12 months postoperatively.ResultsDuring hospitalization, there were no significant differences in the MACE rates, LVEDD, and EF values and in the follow‐up outcomes at 1, 3, 6, and 12 months postoperatively among the patients in the 2 groups (P > 0.05). A significantly lower number of stents were implanted in the IVUS group than in the non‐IVUS group patients (P < 0.05).ConclusionDuring the IVUS‐guided emergency intervention, enhanced antithrombotic therapy and best medical care for low‐risk STEMI patients may be feasible.
Foreign Bodies in the Heart
Authors: Leitman Marina , Vered Zvi 
Published: October 2014

BackgroundForeign bodies in the heart are rare, may reach the heart by different ways, and cause serious complications. X‐ray, computerized tomography, and echocardiography are main diagnostic modalities. Foreign body can be removed surgically, percutaneously or can be managed conservatively. In this work, we analyzed 100 published cases of a foreign body in the heart and 4 cases that were identified in our hospital.MethodsWe searched the literature for foreign body in the heart and found 100 published previously cases. Additional 4 cases were identified in our echo laboratory. A total series of 104 patients with a foreign body in the heart were analyzed for the etiology, clinical presentation, symptoms, complications and management.ResultsMean patients' age was 46, there were more men than woman 73 versus 31 [P < 0.00005]. The most common foreign bodies were parts of inferior vena cava filters and devices implanted for relieving hydrocephalus. Foreign bodies in the heart were symptomatic in 56% of patients. Right heart chambers were occupied more often. A total of 20% presented within the first 24 hours and 30% of patients presented years after the penetration of the foreign body. A majority of foreign bodies reached the heart by migration [88%]. Mortality was reported in 4 patients [3.8%]. Here 54% of the patients underwent surgical and 29% percutaneous removal of the foreign body, while 14% were followed conservatively.ConclusionForeign bodies in the heart may present with a wide variety of symptoms. Physicians should be aware of this rare and peculiar complications which may be fatal. Larger devices may result in more severe complications.
A Residual Intramyocardial Cystic Dissection after Cardiac Fibroma Resection
Authors: Bai Wenjuan , Zeng Lijun , Rao Li 
Published: October 2014

Mini‐AbstractThe article discusses a residual intramyocardial cystic dissection as a complication after cardiac fibroma resection. It indicates the usefulness of echocardiography, especially three‐dimensional echocardiography, to get a complete picture of the entire lesion.
Genome‐wide miRNA profiling in myelodysplastic syndrome with del(5q) treated with lenalidomide
Authors: Merkerova Michaela Dostalova , Krejcik Zdenek , Belickova Monika , Hrustincova Andrea , Klema Jiri , Stara Eliška , Zemanova Zuzana , Michalova Kyra , Cermak Jaroslav , Jonasova Anna 
Published: October 2014

AbstractObjectivesLenalidomide is a potent drug with pleiotropic effects in patients with myelodysplastic syndrome (MDS) with deletion of the long arm of chromosome 5 [del(5q)]. We investigated its effect on regulation of microRNA (miRNA) expression profiles in del(5q) patients with MDS in vivo.MethodsWe used miRNA expression microarrays to study changes in miRNA levels in peripheral blood CD14+ monocytes collected from patients before and during lenalidomide treatment and compared them with those from healthy donors.ResultsBefore treatment, we observed strong upregulation of pro‐apoptotic miR‐34a and miR‐34a* that diminished during lenalidomide exposure. Upregulation of HOX‐related miR‐196b and erythroid‐specific miR‐451 seen in untreated patients remained unchanged after the treatment. At the time of hematologic response, expression of several miRNAs clustering to the 14q32 locus was reduced. Additionally, we focused more deeply on miRNAs from the 5q commonly deleted region and found that levels of miR‐378 and miR‐378* followed haploinsufficiency trend.ConclusionsThis report describes changes in miRNA expression in del(5q) patients with MDS treated with lenalidomide, likely arising from deregulation of pathways implicated in lenalidomide action.
Associative plasticity in surround inhibition circuits in human motor cortex
Authors: Belvisi Daniele , Kassavetis Panagiotis , Bologna Matteo , Edwards Mark J. , Berardelli Alfredo , Rothwell John C. 
Published: October 2014

AbstractSurround inhibition is a physiological mechanism that is hypothesised to improve contrast between signals in the central nervous system. In the human motor system, motor surround inhibition (mSI) can be assessed using transcranial magnetic stimulation (TMS). We evaluated whether it is possible to modulate mSI, using a paradigm able to induce plastic effects in primary motor cortex (M1). Fifteen healthy volunteers participated in the experiments. To assess mSI, we delivered single pulses at rest and at the onset of a right thumb abduction. TMS pulses over abductor digiti minimi (ADM; surround muscle) hotspot were delivered when EMG activity in right abductor pollicis brevis (APB; active muscle) > 100 μV was detected. Paired associative stimulation (PAS) was delivered using peripheral median nerve electric stimulation and TMS over APB M1 area at an interstimulus interval of 21.5 ms for the real PAS (PAS21.5) and 100 ms for the sham PAS (PAS100). To verify the effect of PAS21.5 on mSI we collected 20 MEPs from ADM at rest and during APB movements before (T0) and 5 (T1), 15 (T2) and 30 (T3) minutes after PAS21.5. mSI from APB to ADM was present at baseline. PAS21.5 increased the amount of mSI compared with baseline whereas there was no effect after PAS100. Our results suggest that mSI is an adaptable phenomenon depending on prior experience.
The effects of transcranial direct current stimulation on conscious perception of sensory inputs from hand palm and dorsum
Authors: Westgeest Annette , Morales Merche , Cabib Christopher , Valls‐Sole Josep 
Published: October 2014

AbstractConscious perception of sensory signals depends in part on stimulus salience, relevance and topography. Letting aside differences at skin receptor level and afferent fibres, it is the CNS that makes a contextual selection of relevant sensory inputs. We hypothesized that subjective awareness (AW) of the time at which a sensory stimulus is perceived, a cortical function, may be differently modified by cortical stimulation, according to site and type of the stimulus. In 24 healthy volunteers, we examined the effects of transcranial direct current stimulation (tDCS) on the assessment of AW to heat pain or weak electrical stimuli applied to either the hand palm or dorsum. We also recorded the vertex‐evoked potentials to the same stimuli. The assessment was done before, during and after cathodal or anodal tDCS over the parietal cortex contralateral to the hand receiving the stimuli. At baseline, AW to thermal stimuli was significantly longer for palm than for dorsum (P < 0.01), while no differences between stimulation sites were observed for the electrical stimuli. Both cathodal and anodal tDCS caused a significant shortening of AW to thermal stimuli in the palm but not in the dorsum, and no effects on AW to electrical stimuli. Longer AW in the palm than in the dorsum may be attributable to differences in skin thickness. However, the selectivity of the effects of tDCS on AW to thermal stimulation of the glabrous skin reflects the specificity of CNS processing for site and type of sensory inputs.
Spectrotemporal dynamics of the EEG during working memory encoding and maintenance predicts individual behavioral capacity
Authors: Bashivan Pouya , Bidelman Gavin M. , Yeasin Mohammed 
Published: October 2014

AbstractWe investigated the effect of memory load on encoding and maintenance of information in working memory. Electroencephalography (EEG) signals were recorded while participants performed a modified Sternberg visual memory task. Independent component analysis (ICA) was used to factorise the EEG signals into distinct temporal activations to perform spectrotemporal analysis and localisation of source activities. We found ‘encoding’ and ‘maintenance’ operations were correlated with negative and positive changes in α‐band power, respectively. Transient activities were observed during encoding of information in the bilateral cuneus, precuneus, inferior parietal gyrus and fusiform gyrus, and a sustained activity in the inferior frontal gyrus. Strong correlations were also observed between changes in α‐power and behavioral performance during both encoding and maintenance. Furthermore, it was also found that individuals with higher working memory capacity experienced stronger neural oscillatory responses during the encoding of visual objects into working memory. Our results suggest an interplay between two distinct neural pathways and different spatiotemporal operations during the encoding and maintenance of information which predict individual differences in working memory capacity observed at the behavioral level.
Sporting Justifications under EU Free Movement and Competition Law: The Case of the Football ‘Transfer System’
Authors: Pearson Geoff 
Published: October 2014

AbstractGoverning bodies have significant autonomy in the organisation of professional sport in the EU, a situation now supported by Article 165 TFEU. However the post‐Lisbon competence for sport does not grant any exemption for practices that infringe fundamental freedoms or competition law; such infringements can only be justified where they are a proportionate response to an inherent need in that sport. The football ‘transfer system’ has been the subject of a series of EU law challenges, but continues to place obstacles in the way of the free movement of players between Member States and may restrict the ability of most clubs to compete for the elite players. Court of Arbitration for Sport decisions in transfer dispute cases have entrenched this situation, and recent evidence casts doubt on both the ability of the authorities to justify the current system and the 2001 decision by the European Commission to sign it off as being an acceptable balance between the rights of the stakeholders.
A hybrid model for business process event and outcome prediction
Authors: Le Mai , Gabrys Bogdan , Nauck Detlef 
Published: October 2014

AbstractLarge service companies run complex customer service processes to provide communication services to their customers. The flawless execution of these processes is essential because customer service is an important differentiator. They must also be able to predict if processes will complete successfully or run into exceptions in order to intervene at the right time, preempt problems and maintain customer service. Business process data are sequential in nature and can be very diverse. Thus, there is a need for an efficient sequential forecasting methodology that can cope with this diversity. This paper proposes two approaches, a sequential k nearest neighbour and an extension of Markov models both with an added component based on sequence alignment. The proposed approaches exploit temporal categorical features of the data to predict the process next steps using higher order Markov models and the process outcomes using sequence alignment technique. The diversity aspect of the data is also added by considering subsets of similar process sequences based on k nearest neighbours. We have shown, via a set of experiments, that our sequential k nearest neighbour offers better results when compared with the original ones; our extension Markov model outperforms random guess, Markov models and hidden Markov models.
Pronounced chemical response of Subarctic lakes to climate‐driven losses in surface area
Authors: Lewis Tyler L. , Lindberg Mark S. , Schmutz Joel A. , Heglund Patricia J. , Rover Jennifer , Koch Joshua C. , Bertram Mark R. 
Published: October 2014

AbstractLosses in lake area have been observed for several Arctic and Subarctic regions in recent decades, with unknown consequences for lake ecosystems. These reductions are primarily attributed to two climate‐sensitive mechanisms, both of which may also cause changes in water chemistry: (i) increased imbalance of evaporation relative to inflow, whereby increased evaporation and decreased inflow act to concentrate solutes into smaller volumes; and (ii) accelerated permafrost degradation, which enhances sublacustrine drainage while simultaneously leaching previously frozen solutes into lakes. We documented changes in nutrients [total nitrogen (TN), total phosphorus (TP)] and ions (calcium, chloride, magnesium, sodium) over a 25 year interval in shrinking, stable, and expanding Subarctic lakes of the Yukon Flats, Alaska. Concentrations of all six solutes increased in shrinking lakes from 1985–1989 to 2010–2012, while simultaneously undergoing little change in stable or expanding lakes. This created a present‐day pattern, much weaker or absent in the 1980s, in which shrinking lakes had higher solute concentrations than their stable or expanding counterparts. An imbalanced evaporation‐to‐inflow ratio (E/I) was the most likely mechanism behind such changes; all four ions, which behave semiconservatively and are prone to evapoconcentration, increased in shrinking lakes and, along with TN and TP, were positively related to isotopically derived E/I estimates. Moreover, the most conservative ion, chloride, increased >500% in shrinking lakes. Conversely, only TP concentration was related to probability of permafrost presence, being highest at intermediate probabilities. Overall, the substantial increases of nutrients (TN >200%, TP >100%) and ions (>100%) may shift shrinking lakes towards overly eutrophic or saline states, with potentially severe consequences for ecosystems of northern lakes.
Deep fluid circulation within crystalline basement rocks and the role of hydrologic windows in the formation of the Truth or Consequences, New Mexico low‐temperature geothermal system
Authors: Pepin J. , Person M. , Phillips F. , Kelley S. , Timmons S. , Owens L. , Witcher J. , Gable C. 
Published: October 2014

AbstractHot springs can occur in amagmatic settings, but the mechanisms of heating are often obscure. We have investigated the origin of the Truth or Consequences, New Mexico low‐temperature (approximately 41°C) hot springs in the southern Rio Grande Rift. We tested two hypotheses that could account for this amagmatic geothermal anomaly: lateral forced convection in a gently dipping carbonate aquifer and circulation through high‐permeability crystalline basement rocks to depths of 8 km that is then focused through an overlying faulted hydrologic window. These hypotheses were tested using a regional two‐dimensional hydrothermal model. Model parameters were constrained by calibrating to measured temperatures, specific discharge rates, and groundwater residence times. We collected 16 temperature profiles, 11 geochemistry samples, and 6 carbon‐14 samples within the study area. The geothermal waters are Na+/Cl−‐dominated and have apparent groundwater ages ranging from 5500 to 11 500 years. Hot‐spring geochemistry is consistent with water/rock interaction in a silicate geothermal reservoir, rather than a carbonate system. Peclet number analysis of temperature profiles suggests that specific discharge rates beneath Truth or Consequences range from 2 to 4 m year−1. Geothermometry indicates maximum reservoir temperatures are around 170°C. Observed measurements were reasonably reproduced using the deep circulation permeable‐basement modeling scenario (10−12 m2) but not the lateral forced‐convection carbonate‐aquifer scenario. Focused geothermal discharge is the result of localized faulting, which has created a hydrologic window through a regional confining unit. In tectonically active areas, such as the Rio Grande Rift, deep groundwater circulation within fractured crystalline basement may play a more prominent role in the formation of geothermal systems than has generally been acknowledged.
Short‐Term Complications After Colic Surgery in Geriatric Versus Mature Non‐Geriatric Horses
Authors: Gazzerro Deanna M. , Southwood Louise L. , Lindborg Sue 
Published: October 2014

ObjectiveTo compare in geriatric and mature horses the occurrence of short‐term complications and short‐term outcome associated with complications after colic surgery.Study DesignRetrospective case–control study.Sample PopulationHorses aged ≥20 years (geriatric, n = 78) and 4–15 years (mature non‐geriatric, n = 156) that had exploratory celiotomy for colic and survived recovery from general anesthesia.MethodsMedical records (2000–2010) of horses that recovered from general anesthesia after colic surgery were reviewed. Postoperative complications evaluated included postoperative reflux (POR), diarrhea, inappetence, fever, leukopenia, incisional infection, incisional dehiscence, thrombophlebitis, colic, repeat celiotomy, pneumonia, and laminitis. Short‐term outcome (alive vs. dead at hospital discharge) of geriatric and mature horses with these complications were compared. Data were analyzed using a χ2or Fisher's exact test or an ANOVA. Level of significanceP < .05.ResultsGeriatric horses had higher odds of having a small intestinal strangulating lesion than mature horses. A higher proportion of geriatric horses had POR and inappetence; however, there was no difference in the proportion of geriatric and mature horses with small intestinal strangulating lesions having POR. Short‐term outcome with and without complications was similar between the 2 age groups.ConclusionGeriatric and mature horses have similar occurrences of short‐term complications and short‐term outcomes associated with complications after colic surgery.
Subtly offending feedback
Authors: Krings Rabea , Jacobshagen Nicola , Elfering Achim , Semmer Norbert K. 
Published: October 2014

AbstractProviding acceptable negative feedback is difficult because it may threaten the receiver's self‐esteem. Studies have established that destructive feedback elicits stronger negative reactions than constructive feedback. However, these destructive conditions were quite strong, implying a clear threat to the self. Because of the importance of protecting one's self‐concept, negative evaluations might be provoked by more subtle cues. Such cues should also be detected by observers.We developed three variants of subtly offending feedback in which mistakes appeared disproportionately serious. In an experimental pilot study, 132 student observers judged the fairness of feedback given to another student. The subtly offending conditions were evaluated as less fair than constructive feedback but as more fair than destructive feedback.
Fit for persuasion: the effects of nonverbal delivery style, message framing, and gender on message effectiveness
Authors: Jacks Julia Zuwerink , Lancaster Lesia C. 
Published: October 2014

AbstractThis study examined two experimental variables, delivery style and message framing, that have yet to be examined together in the regulatory fit literature. College students (mean age = 30) watched a video message encouraging regular exercise delivered in an eager or vigilant nonverbal style and framed in terms of gain or loss. Results revealed significant fit effects involving gender, delivery style, and message framing. The eager message was perceived as more effective by men whereas the vigilant message was perceived as more effective by women. A message framing by delivery style fit effect also emerged for perceived message effectiveness. The implications and limitations of these findings are discussed.
Human values and non‐adherence to doctors' instructions across Europe
Authors: Ahola Salla 
Published: October 2014

AbstractThis study examines the relationships between human values and patient non‐adherence. Two types of non‐adherence are studied: non‐adherent views and non‐adherent behavior in response to doctor's instructions. The study uses data from the European Social Survey Round 2 from 14 countries: Austria, Belgium, Denmark, Estonia, Finland, France, Germany, Iceland, Luxembourg, Netherlands, Norway, Poland, Sweden, and Switzerland. Correlation analyses and multiple logistic regression analyses were conducted both using the pooled data from these 14 countries and within countries. The sample size ranged from n = 20,012 to n = 21,600 in the analyses of pooled data. Human values were found to be associated with non‐adherence. As hypothesized, endorsing openness‐to‐change values (vs. conservation values) was positively related to non‐adherent views and behavior.