bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico exploration of bioactive compounds from Acorus calamus L. for targeted treatment of ischemic heart disease: Molecular insights and therapeutic prospects
Authors: Sahu Tripura , Vedantam Giridhar , Vetrivel Umashankar 
Published: July 2024

Abstract

BACKGROUND:
Ischemic heart disease (IHD) accounts for 80%–85% of mortality, highlighting the need to develop effective and noninvasive management strategies. Lekhana karma (therapeutic scrapping) helps in balancing the imbalanced Kapha and Medodhatu, which are important factors in the pathogenesis of IHD. Vacha—Acorus calamus Linn (AC) is 1 of the 10 Lekhaneeya drugs described in Charaka Samhita and is widely available and cost-effective. However, its bioactive phytoconstituents’ mode of action and molecular entities remain unexplored. Hence, this study aimed to elucidate the mode of action of its bioactive compounds and their interaction with IHD disease targets and pathways.

METHODS:
Phytochemicals from AC were collected, followed by screening of bioactive phytochemicals, collecting gene identifications, and pathways related to IHD. Later, common compounds and pathways were identified, and common targets between phytochemicals and pathways were sorted. A further network of phytochemicals-pathways-targets was constructed followed by molecular docking of highly enriched disease targets and phytochemicals.

RESULTS:

An in silico study revealed that 19 main active compounds of AC are interacting with 48 targets involved in regulating biological processes in the IHD. Molecular docking analyses were performed to explore the potential and affinity of these compounds with disease targets. Galangin, alpha-asarone, beta-asarone, and isoelemicin exhibited significant interactions with IHD disease targets, such as prostaglandin G/H synthase 2, cytochrome P450 1A2, transcription factor p65, vascular endothelial growth factor A, and tyrosine-protein kinase. Additionally, the study identified the interaction between the top 4 phytochemicals and the five most enriched disease targets.

CONCLUSION:
These findings provide a promising avenue for transforming bioactive phytoconstituents in AC into novel drug entities for treating IHD. The in silico approach identifies therapeutic targets, guides wet lab studies, and aids multi-compound management for IHD.
Effectiveness of error-based active learning compared to conventional lecture-based method among undergraduate dental students: A randomized controlled trial
Authors: Varghese Anu Sara , Sankeshwari Roopali M. , Ankola Anil V. , Santhosh Varkey Nadakkavukaran , Chavan Prajakta , Hampiholi Vinuta , Khot Atrey J. Pai , Shah Mehul A. 
Published: July 2024

INTRODUCTION:
Dental education assumes an indispensable role in adequately equipping students for a successful career in dentistry. Error-based active learning, an innovative approach in dental education, is a combination of mistake-driven learning (MDL) and case-based learning (CBL) to provide a transformative learning atmosphere for students. While active learning has gained popularity in dental education, the effectiveness of error-based active learning remains unexplored. This study aims to evaluate the effectiveness of error-based active learning among final-year dental undergraduate students in comparison with the conventional lecture-based approach.

MATERIALS AND METHODS:
A parallel-arm single-blind randomized controlled trial was conducted in a dental institute in India from November 2022 to December 2022. A total of 74 students were randomly allocated to two groups: Group A (n = 37) received error-based active learning and group B (n = 37) received conventional lecture-based learning approach. Atraumatic restorative treatment (ART) was chosen as the topic for the study. The knowledge of students was assessed at three intervals: baseline, post-intervention, and 4 weeks after the intervention, using a self-designed and validated questionnaire with Cronbach’s alpha of 0.87 and a content validity ratio of 0.84. A standard survey questionnaire was employed to evaluate students’ perceptions of the teaching methods.

RESULTS:
Error-based active learning group outperformed the lecture-based group significantly in the post-intervention test (20.92 ± 1.42 vs 16.97 ± 3.06), with better knowledge retention (18.30 ± 2.02 vs 14.05 ± 4.26) and positive feedback from the students.

CONCLUSIONS:
The error-based active learning approach proved superior to the conventional lecture-based method in enhancing and retaining knowledge regarding ART.
Exploring the psychological problems of mothers having the experience of death of children with untreatable genetic disorders: A qualitative study
Authors: Kermanian Marzyeh , Khodayarian Mahsa , Tafti Abbasali Dehghan , Salmani Naiire 
Published: July 2024

BACKGROUND:
A newborn with an untreatable genetic disorder could disrupt a family and affect parents’ mental health, psycho-social interaction, and parent–child relationships. This study was conducted to explore the psychological problems of mothers having the children with untreatable genetic disorders.

MATERIALS AND METHODS:
This qualitative study was performed using the conventional content analysis method on 15 mothers having the children with untreatable genetic disorders selected by purposeful sampling. In-depth and semi-structured interviews were used to collect data. The recorded interviews were transcribed verbatim immediately and imported into MAXQDA10 software. Lundman and Granheim’s content analysis method and Guba and Lincoln’s proposed criteria for assessing rigor of the results were used.

RESULTS:
Overall, 1067 primary codes were extracted from the interviews and after the integration of similarities grouped into 19 sub-categories and three major categories including psychological reactions before diagnosis, after determined diagnosis, and after the child’s death.

CONCLUSIONS:
The results showed that having the child with untreatable genetic disorder is considered as a notable psychological trauma and causes painful psychological reactions in parents. In this regard, the following approaches are recommended to health professionals: continuous monitoring of mental health of these families, developing a family education program, emotional and psychological support, and genetic counseling.
Effect of nurse-Led psychosocial intervention on body image distress and treatment compliance among patients undergoing treatment of cancer: A randomized controlled trial
Authors: Ranaut Ria , Pareek Bharat , Samual Shweta 
Published: July 2024

BACKGROUND:
Dissatisfaction with one’s physique is the most common issue among cancer patients, and it is correlated with stress, anxiety, and hopelessness. The current study aimed to assess how the Nurse-Led short psychosocial intervention affected cancer patients’ body image distress and treatment compliance.

MATERIALS AND METHODS:
67 patients above 18 years of age and undergoing cancer treatment were enrolled in the study through complete enumeration sampling. The individuals were divided into experimental and control groups using simple randomization. A nurse-led brief psychosocial intervention program was implemented for 15 days for the experimental group while the control group was on standard treatment. The intervention’s effects were measured on the 15th day using a structured body image distress scale and self-structured treatment compliance scale. The consolidated norms of reporting trials (CONSORT) statement was used to perform the study. Utilizing SPSS, descriptive and inferential statistics were performed to analyze the data.

RESULTS:
Post-intervention on the 15th day of the program revealed a reduction in Body image distress (Mean, SD and P value; 2.73, 1.72 (experimental), 4.90 ± 2.23 (control) and <0.001). The program also resulted in improved treatment compliance (Mean, SD and P value; 3.66, 2.23 and (experimental) and 5.83, 1.62; and <0.001).

CONCLUSION:
According to the study’s findings, nurses are essential to the care of cancer patients. Nurse-led intervention can be an effective strategy to address these psychological issues and concerns.
Flipped classroom as an effective educational tool in teaching physiology for first-year undergraduate medical students
Authors: Prabhavathi K , KalyaniPraba P , Rohini P , Selvi K Thamarai , Saravanan A 
Published: July 2024

BACKGROUND:
Flipped classroom (FC) teaching has recently received much attention in medical education. It has been introduced in our institution for 2 years, and we studied the effectiveness and perception of FC teaching in Physiology for first-year undergraduate students.

MATERIALS AND METHODS:
In total, 150 out of 250 first-year MBBS students participated in this study. They were divided into two groups, each consisting of 75 students. Multiple topics in the cardiovascular system were taught to the students by employing traditional classroom (TC) didactic lectures in group A. The same topics were handled using FC in group B, where the students came prepared with the study materials the facilitator provided before class commenced. A well-planned classroom discussion with a formative assessment was conducted at the end. The test scores were compared between the two groups by using an independent t-test. A feedback report was obtained from both groups’ students to analyze the teaching-learning methods’ accomplishment.

RESULT:
FC teaching scores were significantly higher than the traditional lecture among all students. Feedback results showed that 93% of students agreed that the resource materials, group discussions, videos, and exercise tools used in FC were very useful; 95% of students agreed that it provided a good understanding and better appreciation of basic science knowledge in health and disease, and 91% reported that it was well-organized with good interaction, clear explanation, relevant information, and encouraged critical thinking with active student participation.

CONCLUSION:
FC proves to be an effective, interesting, and motivating teaching-learning module. It enhances communication skills, clinical thinking, interaction, and active student participation.
Learning styles and test anxiety in nursing students
Authors: Mousavi Seyed Kazem , Kamali Mohsen , Saed Omid 
Published: July 2024

BACKGROUND:
Test anxiety has always been a common problem among students, which may be influenced by various factors such as learning styles. Considering the high prevalence of test anxiety in nursing students, the present study investigated the relationship between their learning styles and test anxiety.

MATERIALS AND METHODS:
The present research was a correlational descriptive study conducted in January of 2023, in which 235 students from the first to sixth semesters in two nursing schools affiliated with Zanjan University of Medical Sciences were selected by stratified random method. The data collection tools included demographic questionnaires, Kolb’s learning styles, and Sarason’s test anxiety, completed by the self-report method. The data were analyzed using descriptive and inferential statistics by SPSS (v. 26).

RESULTS:
The mean test anxiety score in students was 28.30 ± 3.56, which showed a high level of test anxiety, and most of them had a divergent learning style (32.2%). The highest mean of test anxiety was among students with divergent learning styles. Also, the relationship between learning styles and test anxiety is statistically significant. The LSD test for more detailed information showed that the level of test anxiety with divergent learning styles is significantly higher than those with convergent learning styles (P < 0.05).

CONCLUSION:
The findings showed that students with divergent learning styles suffer the highest test anxiety level. Considering that most nursing students participating in this research had divergent learning styles, it can be one reason for their high test anxiety. Because students with divergent learning styles mainly learn through seeing and experiencing, one of the solutions to reduce test anxiety in these students is to use observational learning methods as much as possible during teaching. Holding anxiety control and management workshops before the exam by psychological experts can be considered by educational managers.
Patterns of caffeine consumption among medical undergraduates in Secunderabad, Telangana, India
Authors: Pulla Anupama , Syed Asma , Bolisetti Venu 
Published: July 2024

BACKGROUND:
Caffeine products are increasingly found in a wide range of products that abuse of the substance may be unnoticed. Introduction of new energy drinks has led to an increase in consumption of caffeine in the last few decades. Caffeine is a cognitive booster and has physically enhancing effects, leading to its higher consumption across various age groups. The objective of this study was to determine patterns of caffeine consumption and to determine the knowledge and awareness of side effects and safety limits of caffeine consumption among medical undergraduate students.

MATERIAL AND METHODS:
A cross-sectional study was conducted from December 2021 to February 2022 in the Department of Community Medicine at a tertiary care institute, Secunderabad, Telangana, India, among 560 medical undergraduate students of all academic years. A predesigned, pretested, semistructured questionnaire was administered.

RESULTS:
The mean age of the study population was 19.09 years, and female preponderance (61.2%) was noted. The average self-reported caffeine consumption was 151.3 mg/day. The average caffeine consumption was found to be higher among males (174 mg/day) as compared to females (137 mg/day). The average consumption of caffeine during exam time was higher than the daily ceiling limit, >300 mg/day, in 38.1% of students, which was statistically significant (P = 0.015).

CONCLUSIONS:
Caffeine consumption during times of stress increased among medical students, which is an unfavorable sign as the majority of the times, medical students in future have to deal with physically and emotionally stressful situations during work hours.
Predicting cervical cancer screening participation using self-care behaviors among women in Iran
Authors: Ghasemi Marzieh , Savabi-Esfahani Mitra , Noroozi Mahnaz , Sattari Mohammad 
Published: July 2024

BACKGROUND:
Cervical cancer screening is an effective and accessible method for preventing this cancer. However, low participation rates among women have been reported. Self-care is one of the solutions to improve access to health services. This study was conducted to determine the prediction of cervical cancer screening participation using self-care behaviors among women in Iran.

MATERIALS AND METHODS:
This cross-sectional study was conducted on 310 eligible women who were referred to comprehensive health centers and women’s clinics in teaching hospitals in Isfahan, Iran, from November 2020 to April 2021. Participants were enrolled using convenience sampling. The data collection tool included researcher-made questionnaires on personal and fertility characteristics, participation in cervical cancer screening, and self-care behaviors related to cervical cancer and its screening. Descriptive and inferential statistical methods were used for data analysis using the Statistical Package for the Social Sciences (SPSS) version 22 software.

RESULTS:
The results showed that the intention to undergo screening was low among individuals who had not undergone screening. Lack of awareness and not having enough time were the most common barriers to screening. The results of logistic regression analysis indicated that self-efficacy was the significant predictor of cervical cancer screening. With an increase in the self-care score, the 12% chance of doing a Pap smear increases significantly (P = 0.002). Furthermore, the results of multiple regression showed that with an increase in the self-care score, the chance of women who refer to screening every year, every 2–3 years, and every 4–5 years is increased to 25% (P = 0.001), 34% (P < 0.001), and 11% (P = 0.032), respectively, compared with non-referral.

DISCUSSION:
According to the results, self-care was a predictor of performing a Pap smear, and it was related to its regular performance of Pap smear too. Therefore, designing and implementing necessary interventions to increase self-care behaviors can improve women’s participation in cervical cancer screening and its regularity.
Empty nest syndrome: A concept analysis
Authors: Khatir Maryam Ahmadi , Modanloo Mahnaz , Dadgari Ali , Yeganeh Leila Teymouri , Khoddam Homeira 
Published: July 2024

BACKGROUND:
Empty nest syndrome (ENS) is parents’ experience to their children leaving home. Considering the lack of a clear definition of this concept and its context-based nature, this study aimed to define the ENS concept.

MATERIALS AND METHODS:
A three-phase concept analysis using a hybrid model was used. In the theoretical (first) phase, a literature review was conducted using Scopus, WOS, PubMed, ProQuest, Irandoc, Research.idml, Magiran, and SID, with the search terms “empty nest syndrome,” “aged,” and “middle-aged,” and their synonyms, with no time and language restrictions until the end of 2021. After the screening, 29 relevant articles entered the study. According to the findings of the first phase, the fieldwork (second) phase was directed using the qualitative content analysis approach, and semi-structured interviews were conducted with nine elderly and middle-aged individuals with an open-ended question. Results from both were included in the final (third) phase.

RESULTS:
The theoretical phase created an operational definition to guide the fieldwork phase. The fieldwork phase resulted in the emergence of six themes. The final analysis phase formulated a comprehensive definition of this concept: “ENS is a subjective phenomenon that occurs as a result of parents’ reaction to their children leaving home.” This transition from crisis to self-regaining includes the stages of mourning or resistance reaction, feelings of loss or passive behaviors, sublimation or impulsive behaviors, adaptation, and relief. It initiates with the last child’s departure and continues until two years.

CONCLUSION:
Exploration of the concept of ENS can be the basis for designing a model or theoretical framework, devising measurement instruments for the concept and its consequences, and developing programs to increase the healthcare team’s awareness to identify the problem and conduct appropriate preventive or therapeutic measures.
Epidemiology, clinical features, and outcomes of intussusception in young children: A tertiary center experience
Authors: Thakur Vinit Kumar , Yadav Ramdhani , Prasad Ramjee , Keshri Rupesh , Chaubey Digamber , Rahul Sandip Kumar 
Published: July 2024

Background:
Intussusception in young and old children is different. A study of clinical features, associations, and outcomes of these cases would enhance understanding to guide proper management.

Objectives:
Analysis of the epidemiology, associations, clinical features, and management outcomes of intussusception in children younger than 2 years.

Patients and Methods:
A retrospective descriptive study on intussusception patients younger than 2 years was conducted from January 2018 to December 2022 in the department of pediatric surgery at a tertiary center. Demographic details, clinical features, and management outcomes data were collected and analyzed.

Results:
A total of patients were 133 with mean, median, and modal age of 9.5, 7, and 6 months, respectively; the maximum incidence was in March. 81.95% of cases were idiopathic; important lead points were Meckel diverticulum, inflamed appendix, roundworm, cecal duplication, and intraluminal polyps. Two postoperative cases occurred in Wilms’ tumor and congenital diaphragmatic hernia patients, whereas two postrotavirus vaccination cases were seen. Ten (7.5%) had associated malrotation which necessitated Ladd’s procedure. Only 15 cases presenting early responded to nonoperative treatment (9/15 hydrostatic reduction and 6/15 conservative management); among late presenters, 12.71% had manual reduction, 68.64% had resection and anastomosis while in 16.95%, temporary stoma was needed. Wound infection, burst abdomen, subacute intestinal obstruction, recurrent intussusception, peristomal excoriation, and stomal prolapse were a few complications along with one death.

Conclusion:
Intussusception in children younger than 2 years is a heterogeneous group. Although mostly idiopathic, several associations and well-defined lead points require additional intervention. Early diagnosis and prompt intervention ensure a favorable outcome with fewer complications.
Comparison of diagnostic performance between diffusion models parameters and mono-exponential apparent diffusion coefficient in patients with prostate cancer: A systematic review and meta-analysis
Authors: Nematollahi Hamide , Maracy Mohammad Reza , Moslehi Masoud , Shahbazi-Gahrouei Daryoush 
Published: July 2024

Background:
The importance of diffusion in prostate cancer (PCa) diagnosis has been widely proven. Several studies investigated diffusion models in PCa diagnosis.

Materials and Methods:
This systematic review and meta-analysis study was performed to evaluate the ability of three diffusion models to diagnose PCa from the scientific electronic databases Embase, PubMed, Scopus, and Web of Science (ISI) for the period up to March 2022 to identify all relevant articles.

Results:
Eighteen studies were included in the systematic review section (7 diffusion kurtosis imaging [DKI] studies, 4 diffusion tensor imaging [DTI] studies, 4 intravoxel incoherent motion [IVIM] studies, and 3 IVIM-DKI studies). Pooled sensitivity, specificity, accuracy, and summary area under each diffusion model’s curve (AUC) and 95% confidence intervals (CIs) were calculated. The pooled accuracy and 95% CI on detection (differentiation of tumor from normal tissue and benign prostatic hyperplasia/prostatitis) were obtained for apparent diffusion coefficient (ADC) at 87.97% (84.56%–91.38%) for DKI parameters (Gaussian diffusion [DK] 87.94% [78.71%–97.16%] and deviation from Gaussian diffusion [K] 86.84% [81.83%–91.85%]) and IVIM parameters (true molecular diffusion [DIVIM] 81.73% [72.54%–90.91%], perfusion-related diffusion [D*] 65% [48.47%–81.53%] and perfusion fraction [f] 80.36% [64.23%–96.48%]). The AUC values and 95% CI in the detection of PCa were obtained for ADC at 0.95 (0.92–0.97), for DKI parameters (DK 0.94 [0.89–0.99] and K 0.93 [0.90–0.96]) and for IVIM parameters (DIVIM 0.85 [0.80–0.91], D* 0.60 [0.43–0.77] and f 0.73 [0.63–0.84]). Two studies showed that the DTI accuracy values were 97.34% and 85%. For IVIM–kurtosis model in PCa detection, two studies stated that the DIVIM-K and KIVIM-K accuracy values were 85% and 84.44% (the pooled accuracy; 84.64% with 95% CI 75.78%–93.50%), and 72.50% and 71.11% (the pooled accuracy, 72.10% with 95% CI 64.73%–79.48%), respectively.

Conclusion:
Our findings showed that among the DKI, IVIM, and ADC parameters, it seems that ADC, Dk, DIVIM, and K are the most important, which can be used as an indicator to distinguish PCa from normal tissue. The DKI model probably has a higher ability to detect PCa from normal tissue than the IVIM model. DKI probably has the same diagnostic performance in PCa detection and grading compared to diffusion-weighted imaging and ADC.