bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Overview of The Spinal Metastasis Pain with Opioid Therapy and The Affecting Factor
Authors: Djohansjah Joice Rosewitasari Aryanti , Andriani Rini , Aninditha Tiara , Sofyan Henry Riyanto 
Published: June 2024

Background: Spinal metastasis is the most frequent type of spinal tumor. Opioid is the first line of treatment for cancer pain despite a multitude of side effects. This study aimed to evaluate the effectiveness of opioids as the latest ladder in the treatment of spinal cancer pain. Methods: A retrospective cross-sectional study was performed comprising 89 spinal metastasis patients at the National Cancer Centre, Dharmais Hospital from November 2021 to March 2022. The demographic and clinical data were retrieved from medical records. This study used the Numerical Rating Scale (NRS) to evaluate the improvement of pain. The change of NRS ≥ 2 was considered significant. The data was analyzed using bivariate (Wilcoxon, Mann-Whitney, and Fisher Exact test) and multivariate (linear regression) analysis. Results: A total of 89 subjects were included in the study (median age = 51 years, 57,3% females). There was a significant decrease in the severity of cancer pain (p0.005) between admission (initial NRS 7) and treatment completion (final NRS 2) in the first hospitalization of all groups. There was no correlation between the clinical characteristics of the participants and the NRS score determined upon admission and at the end of the course of treatment. Conclusions: There was a significant improvement in the cancer pain intensity in the subjects with spinal metastasis cancer pain who received opioid naive therapy.
Supraventricular Tachycardia Induced by Cisplatin in a Patient with Breast Cancer: A Case Report
Authors: Laksono Sidhi , Kusharsamita Hillary 
Published: June 2024

Introduction: Cisplatin is one of the most extensively used chemotherapeutic agents for treating many malignancies. Cisplatin chemotherapy, on the other hand, is linked to cardiotoxicity, which may vary from silent arrhythmias to heart failure to sudden cardiac death. In this article, we describe a case of supraventricular tachycardia induced by cisplatin in a breast cancer patient. Case Presentation: Our patient had no history of heart disease and had SVT during cisplatin administration. This condition resolved when the infusion was stopped and amiodarone was administered intravenously. The electrolyte levels were within the usual range. No abnormalities were detected on her echocardiography imaging. Primary cardiotoxicity from cisplatin was subsequently determined to be this patient's root cause of SVT. The patient also had an excellent response to the subsequent cycles of treatment. Conclusions: It is important to note that cisplatin therapy is associated with cardiac toxicity. Arrhythmias such as SVT have been associated with chemotherapy drugs. Hence the ECG has to be closely monitored during cisplatin administration. In addition, An ECG and echocardiogram should be done regularly to rule out the possibility of a secondary form of chemotherapy-induced arrhythmia.
Epidemiological Characteristics and 3-year Overall Survival Outcome of Nasopharyngeal Cancer in Central Java: A Single Institution Retrospective Study
Authors: Liemiyah Rikha , Ruspita Dian Ayu , Naftali Zulfikar , Muyassaroh Muyassaroh , Farokah Farokah 
Published: June 2024

Background: Nasopharyngeal cancer (NPC) has a high incidence and mortality rate in Indonesia, indicating poor survival outcomes. We aimed to evaluate the survival rate of NPC patients and the influence of specific underlying epidemiological characteristics on the overall survival (OS) rate of NPC patients. Methods: We reviewed the medical data from Dr. Kariadi General Hospital's clinical registry system for all newly diagnosed NPC patients between January and December 2018. We retrieved NPC patients' medical record data that met our inclusion/exclusion criteria. The overall survival rate (OS) was estimated using the Kaplan-Meier method. Between-group stratified three-year OS comparisons were conducted using weighted log-rank tests. All statistical analysis was performed in R statistical software. Results: A total of 50 NPC patients were included in the study. Majority of NPC patients were diagnosed in younger age group (58.0%). Male NPC patients dominated this study (74.0%). NPC patients were mostly diagnosed at the advanced stage (76.0%). Nonkeratinizing histology types were frequently found in the study (82.0%). NPC patients achieved a desirable better performance status (78.0%) and had no comorbidities (74.0%). Most NPC patients demonstrated a complete response to therapy (58.0%). The mean follow-up was 26.36 ± 9.5 months and drop-out rate was 18.0%. The three-year OS was 60.8%. Age, sex, stage, histological classification, performance status, comorbidity, therapy response, and therapy drop-out stratified OS did not statistically differ among NPC patients. Conclusions: We found a satisfactory NPC three-year OS. The underlying epidemiological characteristics did not significantly influence the NPC patients' three-year OS.
High CD90 Expression is A Predictor of Axillary Nodal Metastasis in Breast Carcinoma
Authors: Sriwidyani Ni Putu , Dewi I Gusti Ayu Sri Mahendra , Wetan Ni Gusti Ayu Agung Manik Yuniawaty 
Published: June 2024

Background: Metastasis is the most common cause of death in breast cancer and nodal metastasis is one of the most important predictive factors for distance metastasis. One of the intrinsic properties of cancer cells is that they resemble stem cells which are capable of self-renewal, resistance to chemotherapy and radiation, and metastasis. CD90 is a stem cell marker found in several malignancies, including breast carcinoma. The objective of this study was to prove that CD90 can predict the occurrence of axillary nodal metastasis in breast carcinoma. Methods: The study design was a case-control study. The subjects of this study were breast cancer patients at Prof. Dr. I. G. N. G. Ngoerah Hospital who underwent mastectomy and axillary lymphadenectomy in the year 2019. CD90 immunohistochemistry was performed and its association with metastasis, along with various clinicopathological markers, was assessed with chi-square and logistic regression tests with a significance level determined at α=0.05. Results: There were 25 cases of breast carcinoma with axillary nodal metastasis and 25 cases without metastasis. There was a significant relationship between high CD90 expression and the occurrence of nodal metastasis (p=0.010). There was no relationship between patient age, histologic grade, histologic subtype, molecular subtype, and T-stage with axillary nodal metastasis. Breast carcinoma patients with high CD90 expression have a 7.25 times higher nodal metastasis risk compared to patients with low CD90 expression. Conclusion: High CD90 expression could predict axillary nodal metastasis in breast carcinoma.
Sinonasal Schwannoma and Progressive Nasal Obstruction
Authors: Fakhriani Rizka , Herdini Camelia , Yudistira Danu 
Published: June 2024

IIntroduction: Schwannomas, are non-malignant tumors with well-defined encapsulation and gradual growth patterns. These tumors consist of Schwann cells, which originate from the neural crest. The prevalence of schwannoma cases in the head and neck region ranges from approximately 25% to 45%. However, in the sinus cavity, the occurrence is only 4%. Case Presentation: In this study, we provide a clinical case with a 25-year-old female patient with rhinorrhoea symptoms, recurrent epistaxis, and a decreased sense of smell. The patient had a progressive obstruction in the right nasal cavity over one year. A biopsy and computed tomography (CT) scan identified a schwannoma and soft tissue density lesions in the right maxillary ethmoid sinuses and left septal deviation. The confirmation of schwannoma diagnosis is also achieved through histopathological examination. The tumor was surgically excised from the patient's body utilizing lateral rhinotomy and an extirpation technique under general anesthesia. The patient had positive outcomes during the follow-up; the patient revealed the absence of symptoms and no evidence of disease recurrence. Conclusions: Lateral rhinotomy with extirpation methods represents an effective option for managing sinonasal schwannoma due to its ability to access challenging anatomical regions and facilitate the sensitive excision of tumors.
Imaging Profile of Intracranial Tumors at Dr. Zainoel Abidin Regional General Hospital Banda Aceh
Authors: Bintang Khairunnisa Setia , Novirianthy Rima , Hidayaturrahmi Hidayaturrahmi 
Published: June 2024

Background: Brain tumors are divided into two, primary and secondary brain tumors. Primary brain tumors are brain tumors that originate from the brain cells themselves. Meanwhile, secondary brain tumors are tumors that metastasize from tumors located in other parts of the body. Intracranial tumors require imaging modalities to make a diagnosis. Imaging examinations can reveal the type of tumor, location of the tumor, number of lesions, and some radiological features. However, information on imaging examination data of intracranial tumor patients is still limited, especially in Aceh, Indonesia. This study aims to determine the imaging profile of intracranial tumor patients at Dr Zainoel Abidin Regional General Hospital Banda Aceh. Methods: This study design was retrospective descriptive quantitative with the total sampling method. This study was conducted by observing all medical records of intracranial tumor patients recorded from January to December 2022 at Dr. Zainoel Abidin Regional General Hospital Banda Aceh. Results: A total of 88.5% (n=92) of the 104 registered cases were primary intracranial tumors. The most common patient profile was found to be in the range of 46-55 years (25%) and the majority was female (64.4%). The most common type of imaging used was contrast computed tomography (CT)-scan (38.5%), the most common location was supratentorial (74%), the most number of lesions was solitary (83.7%), the most common radiological picture was perifocal edema (66.3%), and the least radiological picture was communicating hydrocephalus (1.9%) and meningeal enhancement (1.9%). Conclusions: There were more patients with primary intracranial tumors than with secondary intracranial tumors. CT scan was the most used imaging to diagnose intracranial tumors. The most intracranial tumors are supratentorial and solitary lesions with perifocal edema as common radiology features. dalities
The Good Quality of Life of Breast Carcinoma with Aggressive Metastasis to Multilevel Vertebrae: A Case Report
Authors: Mannagalli Yusuf , Kirana Ignatia Rosalia , Niatazya Arindita , Utami Lusyhandri Wiga , Pratiwi Dwirani Rosmala 
Published: June 2024

Introduction: Bone is one of the most common metastase sites in breast cancer after lung and liver. Spinal involvement is regarded as an aggressive form of bone metastases due to the risk of neurological dysfunction and paralysis resulting in pain and disability. Therefore, the presence of spinal metastases in breast cancer usually worsens the quality of life (QoL) of patients. This is a persisting challenge in palliative care which aims to improve QoL and provide pain relief. In this case, we reported a 56-year-old female with end-stage breast cancer and extensive spinal involvement who had good QoL based on subjective and objective assessment. Case Presentation: A 56-year-old patient complained of pain in the left breast and back. Physical, imaging, and histopathology examination concluded that the patient suffered from stage IV breast cancer spreading to cervical and lumbal vertebrae, however, the patient reported minimal disturbances in daily activity despite the pain. Objective assessment of quality of life was done using EORTC QLQ-C30, QLQ-BM22, and QLQ-BR23, which revealed a high level of global health status exceeding average breast cancer patients. The high QoL observed in our patient could be attributed to effective symptom management, strong social support, and resilience in coping with the challenges of breast cancer. Conclusions: Continuous psychosocial support, effective symptom management, and strengthening individual resilience have the potential to improve the quality of life in breast cancer patients with spinal metastases.
Synergistic Cytotoxicity of 5-Fluorouracil and Epigallocatechin-3-Gallate on Colorectal Cancer Stem Cell
Authors: Ibrahim Sugeng , Riwanto Ignatius , Suharti Catharina , Putra Agung , Budijitno Selamat 
Published: June 2024

Background: Colorectal cancer stem cells (CR-CSCs) derived from the HCT-116 cell line established human colon carcinoma cell line, validated with CD44+/CD133+. The study investigates the synergistic effects of combining epigallocatechin gallate (EGCG) with 5-fluorouracil (5-FU) on CR-CSCs through comprehensive cytotoxicity assessments, aiming to enhance therapeutic outcomes. EGCG is a polyphenol with anti-cancer activity in green tea. Previous studies have reported that the anti-cancer activity of EGCG involves inhibition of proliferation and induction of apoptosis thereby reducing recurrence by as much as 51.6% in patients with colorectal adenoma after polypectomy. The significance lies in optimizing treatment strategies by understanding the potential synergies between conventional chemotherapeutic agents and natural compounds. Given 5-FU's status as a cornerstone in CR-CSCs chemotherapy and EGCG's emergence as a promising natural compound, the study delves into their individual and combined cytotoxicity profiles. Methods: The single and combination assay aimed to determine the cytotoxicity of EGCG and 5-FU, including establishing the half inhibitory concentration (IC50) and combination index (CI) values. CR-CSCs colonies were disassociated, counted, and cultured in 96-well plates. Test solutions of varying concentrations were applied, and subsequent steps involved incubation, media removal, washing, MTT reagent addition, and absorbance measurement. Results: The single cytotoxicity tests established individual IC50 values, revealing 141.26 µM for 5-FU and 464.56 µM for EGCG. Subsequent combination cytotoxicity tests demonstrated a synergistic effect at specific doses, indicated by CI values below 1. Conclusions: These findings highlight the potential for increased cytotoxicity against CR-CSCs when treated with the combination of 5-FU and EGCG.
Nursing students’ lived experiences with using AIDET in patient communication: A qualitative study in the Philippines
Authors: Madayag Rudena A. , Esteron Jeffrey V. , Lozano Dianne Anne A. , Bautista Evangeline C. , Fernandez Zenaida S. , Ramirez Debbie Q. 
Published: June 2024

Background: Effective communication is vital in nursing, influencing patient safety, satisfaction, and care quality. The AIDET framework is a proven tool for reducing patient anxiety and enhancing their experience. However, perceptions and experiences of Filipino nursing students with AIDET remain unexplored.
Objective: This study explored Filipino nursing students’ use of AIDET, focusing on benefits, challenges, and improvements.
Methods: A qualitative, interpretive phenomenological approach informed by the philosophy of Martin Heidegger was employed. This 2023 study, conducted at a university in Angeles City, Philippines, explored Filipino nursing students’ experiences with the AIDET communication framework. Thirty participants were purposefully selected to participate in facilitated discussions following a semi-structured interview guide. Thematic content analysis of the transcribed audio recording identified recurring themes in their narratives, focusing on the meanings they ascribed to their experiences using AIDET.
Results: Four themes emerged: (a) Streamlined nurse-patient interaction (organizes communication, rapport building, alleviate anxiety, acknowledgment, and empowerment as sub-themes), (b) Enhances patient-centered care (empathy and compassion, improved patient experience as sub-topics), (c) Challenges with specific patient populations (patient preferences, language barrier, patient condition, acknowledgment of cultural differences as sub-themes), and (d) AIDET in nursing education strengthening application through practice, optimizing frequency and timing, promoting deeper understanding, enhancing feedback mechanism) as student nurses’ recommendations.
Conclusion: Early integration of AIDET in nursing education is essential for student nurses to enhance communication, improve patient satisfaction, and deliver patient-centered care, equipping them with valuable communication skills.
Green intellectual capital: The secret ingredient for organizational competitive advantage in the nursing profession—a cross-sectional study from Egypt
Authors: Atalla Amal Diab Ghanem , Elbassal Nariman Ahmed Mohamed Mostafa , Kandil‬‏ Faten Shawky , El-Ashry Ayman Mohamed , Mohamed Ishraga Abdelgadir Ibrahim , Behilak Sahar Elsayed Gaber , Elseesy Naglaa Abdelaziz Mahmoud 
Published: June 2024

Background: In the contemporary healthcare environment, managing human resources expertise is just as imperative as having the supreme amount of working capital. Every business must constantly build its capacity, expertise, and competitive edge by utilizing its intellectual property and experience.

Objective: This study aimed to assess the relationship between green intellectual capital and organizational competitive advantage among nurses.

Methods: The study employed a descriptive correlational design among 350 nurses selected using convenience sampling. Data were collected from March 2023 to June 2023 using the Organizational Competitive Advantage Scale and the Green Intellectual Capital Questionnaire. Data were analyzed using t-test, ANOVA, and Pearson correlation.

Results: Most nurses had a moderate level of green intellectual capital (Mean = 3.60, SD = 0.27). The overall mean score for organizational competitive advantage was moderate (Mean = 3.34, SD = 0.34). The overall score of the green intellectual capital (r = 0.257, p <0.001) and its dimensions—green human capital (r = 0.257, p <0.05), green structure capital (r = 0.257, p <0.001), and green relational capital (r = 0.257, p<0.001)—had significant positive correlations with organizational competitive advantage.

Conclusion: Being eco-friendly has become a determining factor in the organizational competitive advantage. The study highlights the significance of nursing management in establishing partnerships with external entities to share knowledge and advance sustainable healthcare methods. It advocates for assessing organizational environmental performance and its influence on competitive edge through creating metrics, monitoring progress, and utilizing data for decision-making. Healthcare and nurse administrators are advised to set performance benchmarks, track advancements, and integrate eco-friendly strategies to bolster the hospital’s competitiveness in the market.
Nurses-Led Municipal Leadership and Governance Program: Experiences of Local Chief Executives in Central Visayas, Philippines
Authors: Palompon Daisy R. , Naranjo Michele A. , Abalos Evalyn , Omus Nelner , Flores Philip Jerome A. 
Published: June 2024

Background: The strategic response of nurses in addressing health inequities in marginal sectors led to the conduct of a health leadership governance training program for local chief executives.
Objective: This study aimed to explore and provide a description of the experiences of local chief executives (LCEs) or mayors who participated in the nurse-initiated health training named Municipal Leadership and Governance Program (MLGP).
Methods: A qualitative descriptive design was used through key informant interviews of fifteen mayors or local chief executives (LCE) in the provinces of Bohol and Negros Oriental, Philippines. Data were collected from 16 to 20 November 2022 and analyzed using a thematic approach.
Results: The findings generated six themes: a) Leadership capacitation promoting transformative experience, b) Pandemic and program-induced limitations in the training implementation, c) Personal leadership motivation, d) Experiential learning promoting learning as applied in real-world situations, e) Celebrating leadership transformation, and f) 3R’s of MLGP: revisit, review, recommend.
Conclusion: The realizations of the training participants provided valuable implications for the quality of training offered by nurse leaders who advocated the MLGP implementation. It served as a proactive and responsive approach to the health leadership capacitation of mayors. It guided them in their personal realizations that inspired them to apply what they had learned and enabled them to effect experiences of personal to institutional transformation.
Gen Z and Millennials: Contrasts in Reading Behavior and Readerly Identity
Authors: Noorda Rachel , Berens Kathi Inman 
Published: June 2024

Identifying as a reader or not-a-reader is about more than reading behaviors. Reading is a social practice and a form of cultural, and readerly, capital ( Driscoll 2016 ), which is why “the reading practices young people engage in are part of their broader social and cultural participation and, consequently, part of a broader project of identity formation” ( Sellers 2019 ). This article presents nationally representative survey data (n=2075) of Gen Z and millennials residing in the U.S. who don’t identify as readers (“not-a-readers”) to examine the complexity of bookish and non-bookish identity and its connection to reading and media consumption habits. Additionally, this article examines other bookish and non-bookish reading behaviors and identities of Gen Z and millennials to contextualize readers and not-a-readers. We surmise that people are more likely to decline identifying as a reader if the reading they do is not part of their social communities. Our nomenclature: Not-a-readers is about identity; non-reader is about behavior. Surprisingly, not-a-readers are still readers and actually read more than the general survey population when it comes to print books. They visit libraries at rates close to those of readers. People who identify as readers, writers, and fans share some of the same interests in story, but their behaviors are quite different depending upon whether that identity is connected or not to bookish communities. This article addresses larger questions about 1) what counts as reading, and how reports about reading that center book reading miss emergent swaths of activity; 2) the tension between readerly identity and reader behavior; 3) how not-a-readers discover books; 4) how other identities such as writers, fans, and “pirates” intersect with readerly identity.