bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of district energy technology with subsurface thermal storage integration
Authors: Fry Nicholas , Adebayo Philip , Tian Rick , Shor Roman , Mwesigye Aggrey 
Published: August 2024

AbstractRenewable energies, such as solar and wind, traditionally suffer from temporal incongruity. Society’s energy demand peaks occur at different times of day than the electricity generation potential of a photovoltaic panel or, often, a wind turbine. Heat demand, in particular, is subject to a significant mismatch between the availability of heat (in the summer) and the need for heat (in the winter). Thus, a future energy system design should incorporate underground thermal energy storage (UTES) to avoid this temporal mismatch and emphasize thermal applications. Such a basis of design would introduce new methods of energy arbitrage, encourage the adoption of geothermal systems, and decrease the carbon intensity of society. UTES techniques are becoming increasingly sophisticated. These methods of storage can range from simple seasonal storage for residential structures in a grouted borehole array (BTES), to aquifer thermal energy storage (ATES), deep reservoir storage (RTES) in basins, among others. The method that each of these techniques shares is the use of the earth as a storage medium. UTES can also be characterized for electricity production, but this work largely explores applications in heating and cooling, further limited in scope to sensible heat storage (SHS). Heating and cooling processes—residential, commercial, and industrial—make up large fractions of energy demand in North America. This is also true of other locales. With the increasing concerns of climate change, exacerbated by anthropogenic greenhouse gas emissions, developers and municipal planners are strategizing to decarbonize building heating and cooling at district scales. This review covers the integration of UTES techniques with thermal energy network (TEN) technology across large districts. Though storage has long been in use for conventional district heating networks, designs are rapidly innovating, indicating broader applications of UTES integration with a TEN is advantageous from both an efficiency and economic perspective. This rapid innovation indicates the need for the integrated review offered in this paper.
Genomic alterations in two patients with esophageal carcinosarcoma identified by whole genome sequencing: a case report
Authors: Inoue Masazumi , Tsubosa Yasuhiro , Ohnami Sumiko , Tokizawa Kazunori , Mayanagi Shuhei , Ohshima Keiichi , Urakami Kenichi , Ohnami Shumpei , Nagashima Takeshi , Yamaguchi Ken 
Published: August 2024

Abstract
Background
Esophageal carcinosarcoma (ECS) is a relatively rare malignancy, accounting for < 1% of all esophageal cancers. Its etiopathogenesis remains unknown. This study analyzed the genomic abnormalities in sarcomatous tumors from two patients undergoing subtotal esophagectomy using whole genome sequencing to elucidate the key characteristics of ECS.

Case presentation
We identified TP53 driver mutations, copy number gains in 11q13 (including CCND1), and Apolipoprotein B mRNA editing enzyme catalytic polypeptide (APOBEC) signature enrichment in both ECS patients. Along with common genetic abnormalities, we identified CDKN2A driver mutations in case 1 and RAC1, NOTCH1, and TTC28 as novel fusion gene partners of MECOM in case 2. Notably, we detected germline pathogenic variant in Fanconi anemia (FA) complementation group I (FANCI) and group G (FANCG), which are involved in repairing DNA double-strand breaks by homologous recombination, for the first time, in ECS blood samples. These germline variants were truncating-type, Lys1221fs of FANCI (rs1567179036) for case 1 and Gln365Ter of FANCG (rs121434426) for case 2. We also identified somatic changes in cancer-associated pathways, such as PI3K/Akt/mTOR, cell cycle, and NOTCH signaling pathways, and structural chromosomal defects such as chromosome doubling.

Conclusions
Our findings indicate that therapeutic drugs targeting the activation signal or FA pathway might be effective in treating ECS, however, their therapeutic significance should be elucidated in future studies.
A study of predictors of retention to naltrexone maintenance therapy in patients with opioid use disorder: a prospective study
Authors: Lone Burhan Bashir , Jan Neelofer , Kousar Muntaqueem Ul , Bhat Fazle Roub , Rather Yasir Hassan , Rasool Ubaid 
Published: August 2024

Abstract
Objectives
Naltrexone prophylaxis is a well-established treatment for opioid use disorder. Our study aimed to track patients on naltrexone and investigate the factors predictive of retention.

Materials and methods
The study comprised 100 participants initiated on naltrexone, who underwent a 12-week follow-up. We analyzed a range of socio-demographic and clinical variables at 04 and 12 weeks to compare those who remained in treatment program with those who experienced relapse.

Results
The results revealed a predominantly young, unmarried, male, rural-dwelling sample with heroin as the primary opioid. Intravenous use was common (75%), with 57% of the participants exhibiting positive serology results for infections by hepatitis C (HCV), hepatitis B (HBV), and/or human immunodeficiency virus (HIV), and a significant proportion initiating opioids before the age of 20 (31%). The retention rates at 04 and 12 weeks were 83% and 64%, respectively. Several socio-clinical factors including age of initiation of use, rural residence, and comorbid psychiatric illness significantly influenced retention at 04 and 12 weeks.

Conclusion
The findings highlight the importance of tailored interventions that take into consideration the age, residence, socio-economic status, and psychiatric comorbidity to enhance retention rates. Identifying these factors can help improve the effectiveness of treatment programs and promote sustained recovery efforts.
Enhanced wound healing activity of naturally derived Lagenaria siceraria seed oil binary nanoethosomal gel: formulation, characterization, in vitro/in vivo efficiency
Authors: Kamal Nagham H. , Saber Fatema R. , Salama Abeer , Abouhussein Dalia M. N. , Ismail Soha , El-Hefnawy Hala M. , Meselhy Meselhy R. 
Published: August 2024

Abstract
Background
The present study aims to enhance the wound healing potential of the seed oil (SO) of Lagenaria siceraria (Egyptian cultivar) via the preparation of SO-loaded binary nanoethosomal (SO-BNE) gels. SO-BNEs were prepared using 23 factorial design, characterized for vesicle size, zeta potential, polydispersity index, linoleic and oleic acid EE% for ensuring improved skin permeability. The L. siceraria SO, optimized SO-BNE gels (0.5% and 5%) and Mebo® were topically applied in full-thickness wounded rat model twice daily for 10 days.

Results
In the SO-BNE gel groups, the normal appearance of the skin architecture and structure of the dermis was revealed. In addition, the levels of NRF2, TGF-β1 and FOXO1, collagen type I, SMA-α and MIP2 were significantly elevated. The wound healing potential of SO-BNE gels was proposed to be via suppression of oxidative stress and stimulation of skin regeneration biomarkers. Furthermore, the SO screening through GC/MS unveiled high percentages of unsaturated fatty acids. SO was also found to be nontoxic to human skin fibroblast cells; enhanced viability and migration rates at concentration of 50 g/mL by 99.76% and 75.9%, respectively.

Conclusion
These findings demonstrate that the Lagenaria siceraria SO-loaded BNE gels represent a promising delivery for wound healing with enhanced release and bioavailability.
Is the COVID-19 vaccination a ray of hope for the elimination of prevalent infectious diseases in the future?
Authors: Ahmad Tauseef , Feeney Kaylem M. 
Published: August 2024

AbstractIn recent years, many disease outbreaks and pandemics have been reported and have posed serious public health challenges. Therefore, vaccination on a large scale is the only hope to prevent and control these vaccine-preventable diseases. This letter discusses the COVID-19 vaccination's role in preventing other infectious diseases.
Paper-based and mobile application-based self-monitoring tool for healthy dietary intake, development and applicability: a non-randomized trial
Authors: Godevithana Janaka , Wijesinghe Champa Jayalakshmie , Wijesinghe Millawage Supun Dilara 
Published: August 2024

Abstract
Background
Unhealthy diet is a key risk factor for Non-Communicable Diseases (NCDs) that contribute to increased morbidity and premature mortality. With increased computer literacy and mobile phone penetration, there is a high opportunity for mobile application-based interventions. The current study was conducted to develop a mobile application to monitor dietary intake and to assess its acceptability and effectiveness in diet control compared to a similar paper-based intervention.

A mobile application was developed based on research evidence and opinions of local experts. The mobile application was introduced to a selected group of office workers who were in preparation, action, and maintenance stages of the Trans Theoretical Model (TTM) and a paper-based intervention was used as the comparator. Socio-demographic data were collected through a self-administered questionnaire. Participants were followed up for three months for adherence. The effectiveness of interventions was assessed at the end of three months by comparing the progressive change in the stage of change and the change from unhealthy to healthy dietary intake between two groups as primary and secondary outcomes respectively.

Results
Among 123 office workers who participated in the study, 19.5% preferred the mobile intervention over the paper-based intervention. Younger, unmarried office workers and those who do not have children, had a higher acceptance for the mobile intervention (p < 0.05). There was no difference in adherence (in all three months) or outcomes between the two groups of intervention.

Conclusion and recommendations
Mobile application-based interventions are better accepted among the young age group and further studies are recommended to explore their applicability.

Trial registration
The study was registered in the Sri Lankan Clinical Trial Registry (Registration No. SLCTR/2020/025; Date 15th December 2020).
Valorization of hemicellulose waste streams for moisture barrier coatings and hydrophobic films
Authors: Josey Daniel C. , Yadavalli Nataraja S. , Moore Jack C. , Peña Maria J. , Minko Sergiy , Urbanowicz Breeanna R. 
Published: August 2024

AbstractReplacing plastics with renewable and environmentally friendly substitutes is becoming ever more critical as we begin to realize the consequences of their negative impacts on the environment. Plant polysaccharides are the most abundant biopolymers on Earth, and hemicelluloses like xylan that are enriched in many agro-industrial waste streams have vast potential as eco-friendly building blocks for polymer science and engineering. However, xylan is one of the less studied natural polymers for applications that are relevant to the synthetic plastics and polymeric materials markets. Hemicellulose isolated from viscose and Lyocell fiber mills is largely seen as a waste product due to difficulties arising from the potential for structural heterogeneity and its lack of solubility after enrichment. In this work, we developed a strategy to valorize hemicellulose by functionalization with octyl isocyanate to achieve solubility and thermoplastic/hydrophobic properties. Xylan isolated from dissolving pulp waste streams was successfully functionalized with octyl isocyanate in DMSO at an estimated 79% hydroxyl conversion. Reaction parameters, including temperature, time, and stoichiometry were optimized for each reaction. The resultant carbamates of xylan oligo- and monosaccharides have good solubility in chloroform and impressive hydrophobic film forming properties yet retain the composability properties desired for renewable materials that are envisioned to enter the circular bioeconomy. Functionalization of xylan with an aliphatic chain through formation of an aliphatic carbamate is not expected to harbor the same toxicity or carcinogenic characteristics as the reactive isocyanate it is derived from, and thus should not inherently restrict these materials for use in diverse packaging applications. These modified physical properties show that xylan from agro-industrial waste streams has considerable potential to replace petroleum-based feedstocks in the existing packaging industry. In the future, we will continue to further develop strategies for valorization of these materials.
Graphical Abstract
Winging it: hummingbirds alter flying kinematics during molt
Authors: Díaz-Salazar Andrés F. , Garzón-Agudelo Felipe , Smiley Ashley , Cadena Carlos Daniel , Rico-Guevara Alejandro 
Published: August 2024

ABSTRACT
Hummingbirds are well known for their hovering flight, one of the most energetically expensive modes of locomotion among animals. Molt is a costly event in the annual cycle, in which birds replace their feathers, including all their primary feathers, which, in hummingbirds, comprise most of the area of the wing. Despite this, the effects of molt on hovering flight are not well known. Here, we examined high-speed videos (14 individuals of three species from the Colombian Andes recorded at 1200 frames per second) comparing molting and non-molting hummingbirds’ wing kinematics and wingtip trajectories. We found that molting hummingbirds rotated their wings in more acute angles during both downstroke and upstroke compared to non-molting individuals (10° versus 20°, and 15° versus 29°, respectively), while other flight parameters remained unchanged. Our findings show that hummingbirds are capable of sustaining hovering flight and thereby maintaining their weight support even under impressive wing area reductions by adjusting their stroke amplitudes.
High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy
Authors: Slick Rebecca A. , Sutton Jessica , Haberman Margaret , O'Brien Benjamin S. , Tinklenberg Jennifer A. , Mardikar Aashay , Prom Mariah J. , Beatka Margaret , Gartz Melanie , Vanden Avond Mark A. , Siebers Emily , Mack David L. , Gonzalez J. Patrick , Ebert Allison D. , Nagaraju Kanneboyina , Lawlor Michael W. 
Published: August 2024

ABSTRACT
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder affecting 1:3500 male births and is associated with myofiber degeneration, regeneration, and inflammation. Glucocorticoid treatments have been the standard of care due to immunomodulatory/immunosuppressive properties but novel genetic approaches, including exon skipping and gene replacement therapy, are currently being developed. The identification of additional biomarkers to assess DMD-related inflammatory responses and the potential efficacy of these therapeutic approaches are thus of critical importance. The current study uses RNA sequencing of skeletal muscle from two mdx mouse models to identify high mobility group box 1 (HMGB1) as a candidate biomarker potentially contributing to DMD-related inflammation. HMGB1 protein content was increased in a human iPSC-derived skeletal myocyte model of DMD and microdystrophin treatment decreased HMGB1 back to control levels. In vivo, HMGB1 protein levels were increased in vehicle treated B10-mdx skeletal muscle compared to B10-WT and significantly decreased in B10-mdx animals treated with adeno-associated virus (AAV)-microdystrophin. However, HMGB1 protein levels were not increased in D2-mdx skeletal muscle compared to D2-WT, demonstrating a strain-specific difference in DMD-related immunopathology.
Loss of HD-PTP function results in lipodystrophy, defective cellular signaling and altered lipid homeostasis
Authors: Schultz Destiny F. , Davies Brian A. , Payne Johanna A. , Martin Cole P. , Minard Annabel Y. , Childs Bennett G. , Zhang Cheng , Jeganathan Karthik B. , Sturmlechner Ines , White Thomas A. , de Bruin Alain , Harkema Liesbeth , Chen Huiqin , Davies Michael A. , Jachim Sarah , LeBrasseur Nathan K. , Piper Robert C. , Li Hu , Baker Darren J. , van Deursen Jan , Billadeau Daniel D. , Katzmann David J. 
Published: August 2024

ABSTRACT
His domain protein tyrosine phosphatase (HD-PTP; also known as PTPN23) facilitates function of the endosomal sorting complexes required for transport (ESCRTs) during multivesicular body (MVB) formation. To uncover its role in physiological homeostasis, embryonic lethality caused by a complete lack of HD-PTP was bypassed through generation of hypomorphic mice expressing reduced protein, resulting in animals that are viable into adulthood. These mice exhibited marked lipodystrophy and decreased receptor-mediated signaling within white adipose tissue (WAT), involving multiple prominent pathways including RAS/MAPK, phosphoinositide 3-kinase (PI3K)/AKT and receptor tyrosine kinases (RTKs), such as EGFR. EGFR signaling was dissected in vitro to assess the nature of defective signaling, revealing decreased trans-autophosphorylation and downstream effector activation, despite normal EGF binding. This corresponds to decreased plasma membrane cholesterol and increased lysosomal cholesterol, likely resulting from defective endosomal maturation necessary for cholesterol trafficking and homeostasis. The ESCRT components Vps4 and Hrs have previously been implicated in cholesterol homeostasis; thus, these findings expand knowledge on which ESCRT subunits are involved in cholesterol homeostasis and highlight a non-canonical role for HD-PTP in signal regulation and adipose tissue homeostasis.
Phototaxis is a satiety-dependent behavioral sequence in Hydra vulgaris
Authors: Kim Soonyoung , Badhiwala Krishna N. , Duret Guillaume , Robinson Jacob T. 
Published: August 2024

ABSTRACT
Understanding how internal states such as satiety are connected to animal behavior is a fundamental question in neuroscience. Hydra vulgaris, a freshwater cnidarian with only 12 neuronal cell types, serves as a tractable model system for studying state-dependent behaviors. We found that starved hydras consistently move towards light, while fed hydras do not. By modeling this behavior as a set of three sequences of head orientation, jump distance and jump rate, we demonstrate that the satiety state only affects the rate of the animal jumping to a new position, while the orientation and jump distance are unaffected. These findings yield insights into how internal states in a simple organism, Hydra, affect specific elements of a behavior, and offer general principles for studying the relationship between state-dependent behaviors and their underlying molecular mechanisms.
Interactive effects of temperature and salinity on metabolism and activity of the copepod Tigriopus californicus
Authors: Terry Caroline E. , Liebzeit Josie A. , Purvis Ella M. , Dowd W. Wesley 
Published: August 2024

ABSTRACT
In natural environments, two or more abiotic parameters often vary simultaneously, and interactions between co-varying parameters frequently result in unpredictable, non-additive biological responses. To better understand the mechanisms and consequences of interactions between multiple stressors, it is important to study their effects on not only fitness (survival and reproduction) but also performance and intermediary physiological processes. The splash-pool copepod Tigriopus californicus tolerates extremely variable abiotic conditions and exhibits a non-additive, antagonistic interaction resulting in higher survival when simultaneously exposed to high salinity and acute heat stress. Here, we investigated the response of T. californicus in activity and oxygen consumption under simultaneous manipulation of salinity and temperature to identify whether this interaction also arises in these sublethal measures of performance. Oxygen consumption and activity rates decreased with increasing assay salinity. Oxygen consumption also sharply increased in response to acute transfer to lower salinities, an effect that was absent upon transfer to higher salinities. Elevated temperature led to reduced rates of activity overall, resulting in no discernible impact of increased temperature on routine metabolic rates. This suggests that swimming activity has a non-negligible effect on the metabolic rates of copepods and must be accounted for in metabolic studies. Temperature also interacted with assay salinity to affect activity, and with acclimation salinity to affect routine metabolic rates upon acute salinity transfer, implying that the sublethal impacts of these co-varying factors are also not predictable from experiments that study them in isolation.
The Role of Programmatic Accreditation, Certification, and Career Advancement
Authors: Thompson Ben , Richardson Laura A. , Neric Francis 
Published: August 2024

Apply It!
The purpose of this article is to outline the pathway that the exercise profession must follow to establish a professional identity. After reading this article, readers will be reminded of the following:
• Continuing education is a mandatory requirement to maintain one’s professional certification.
• U.S. Bureau of Labor Statistics predicts Exercise Physiologists to have a 10% expected job growth.
Brand Development Strategy to Rejuvenate ‘Jamu’ as Children Nutraceutical Based on Mothers’ Persona
Authors: Madyani Dewi , Wahyurini Octaviyanti Dwi 
Published: August 2024

Indonesia has jamu as its native nutraceutical. Unfortunately, jamu is on verge of becoming extinct as it is often perceived as old, bitter taste and irrelevant with current condition. In order to keep Jamu relevant with current condition, many companies have launched various lifestyle jamu brands. Yet none of brands target children as their main customers. This study used design thinking method to develop brand strategy for jamu to cater Indonesian children market. Subjects of this study were mothers who had kid aged 2-12 years old as main stakeholder in decision making process to buy kid nutraceuticals. To gather primary data this study used hybrid research methods. Qualitative study was conducted to empathize users and online survey with n=126 mothers was conducted for prototype testing. There are three mother personas that have different concerns and behavior in buying jamu for kids. In the testing stage, it found that the level of importance of taste and packaging design were different significantly. Yet, the level of acceptance toward proposed brand concept among personas were not significantly different. This study can be used by manufacturers to develop better brand strategy to grasp mothers’ mind and heartshare.