bluuebunny/crossref_metadata_2025_split huggingface dataset:
TarPred: a web application for predicting therapeutic and side effect targets of chemical compounds
Authors: Liu Xian , Gao Yuan , Peng Jianlong , Xu Yuan , Wang Yulan , Zhou Nannan , Xing Jing , Luo Xiaomin , Jiang Hualiang , Zheng Mingyue 
Published: February 2015

Abstract
Motivation: Discovering the relevant therapeutic targets for drug-like molecules, or their unintended ‘off-targets’ that predict adverse drug reactions, is a daunting task by experimental approaches alone. There is thus a high demand to develop computational methods capable of detecting these potential interacting targets efficiently.
Results: As biologically annotated chemical data are becoming increasingly available, it becomes feasible to explore such existing knowledge to identify potential ligand–target interactions. Here, we introduce an online implementation of a recently published computational model for target prediction, TarPred, based on a reference library containing 533 individual targets with 179 807 active ligands. TarPred accepts interactive graphical input or input in the chemical file format of SMILES. Given a query compound structure, it provides the top ranked 30 interacting targets. For each of them, TarPred not only shows the structures of three most similar ligands that are known to interact with the target but also highlights the disease indications associated with the target. This information is useful for understanding the mechanisms of action and toxicities of active compounds and can provide drug repositioning opportunities.
Availability and implementation: TarPred is available at: http://www.dddc.ac.cn/tarpred.
Contact: hljiang@simm.ac.cn or myzheng@simm.ac.cn
Does CEO compensation impact patient satisfaction?
Authors: Akingbola Kunle , van den Berg Herman A. 
Published: February 2015

Purpose– This study examines the relationship between CEO compensation and patient satisfaction in Ontario, Canada. The purpose of this paper is to determine what impact hospital CEO compensation has on hospital patient satisfaction.Design/methodology/approach– The analyses in this study were based on data of 261 CEO-hospital-year observations in a sample of 103 nonprofit hospitals. A number of linear regressions were conducted, with patient satisfaction as the dependent variable and CEO compensation as the independent variable of interest. Controlling variables included hospital size, type of hospital, and frequency of adverse clinical outcomes.Findings– CEO compensation does not significantly influence hospital patient satisfaction. Both patient satisfaction and CEO compensation appear to be driven primarily by hospital size. Patient satisfaction decreases, while CEO compensation increases, with the number of acute care beds in a hospital. In addition, CEO compensation does not even appear to moderate the influence of hospital size on patient satisfaction.Research limitations/implications– There are several limitations to this study. First, observations of CEO-hospital-years in which annual nominal CEO compensation was below $100,000 were excluded, as they were not publicly available. Second, this research was limited to a three-year range. Third, this study related the compensation of individual CEOs to a measure of performance based on a multitude of patient satisfaction surveys. Finally, this research is restricted to not-for-profit hospitals in Ontario, Canada.Practical implications– The findings seem to suggest that hospital directors seeking to improve patient satisfaction may find their efforts frustrated if they focus exclusively on the hospital CEO. The findings highlight the need for further research on how CEOs may, through leading and supporting those hospital clinicians and staff that interact more closely with patients, indirectly enhance patient satisfaction.Originality/value– To the best of the authors’ knowledge, no research has examined the relationship between hospital CEO compensation and patient satisfaction. This research fills the gap and provides a basis for future research.
Optimum time-censored simple ramp-stress accelerated life test sampling plan for the log-logistic distribution
Authors: Srivastava Preeti Wanti , Sharma Deepmala 
Published: February 2015

Purpose– Acceptance sampling plans are designed to decide about acceptance or rejection of a lot of products on the basis of sample drawn from it. Accelerating the life test helps in obtaining information about the lifetimes of high reliability products quickly. The purpose of this paper is to formulate an optimum time censored acceptance sampling plan based on ramp-stress accelerated life test (ALT) for items having log-logistic life distribution. The log-logistic life distribution has been found appropriate for highly reliable components such as power system components and insulating materials.Design/methodology/approach– The inverse power relationship has been used to model stress-life relationship. It is meant for analyzing data for which the accelerated stress is nonthermal in nature, and frequently used as an accelerating stress for products such as capacitors, transformers, and insulators. The method of maximum likelihood is used for estimating design parameters. The optimal test plan is obtained by minimizing variance of test-statistic that decides on acceptability or rejectibility of lot. The optimal test plan finds optimal sample size, stress rates, sample proportion allocated to each stress and lot acceptability constant such that producer’s risk and consumer’s risk is satisfied.Findings– Asymptotic variance plays a pivotal role in determining the sample size required for a sampling plan for deciding the acceptance/rejection of a lot. The sample size is minimized by optimally designing a ramp-stress ALT so that the asymptotic variance is minimized.Originality/value– The model suggested is of use to quality control and reliability engineers dealing with highly reliable items.
Performance measurement and management for maintenance: a literature review
Authors: Parida Aditya , Kumar Uday , Galar Diego , Stenström Christer 
Published: February 2015

Purpose
– The purpose of this paper is to provide a literature review of the performance measurement (PM) in maintenance. The authors aim to discuss the background and development of the PM for maintenance, besides defining the concept of performance measures for maintenance and the frameworks developed.

Design/methodology/approach
– A detailed and extensive literature search and study was undertaken by the authors on the concept and definition of PM, performance indicators (PIs), maintenance performance indicators and various performance frameworks. The history and theory of PM over different phases of business and technological developments have been critically examined and analysed in this review paper.

Findings
– This paper reviews and presents the different PIs and PM frameworks like; balanced scorecard (BSC), performance prism, performance pyramid and performance matrix, etc., and identifies their characteristics and shortcomings. After considering related issues and challenges, frameworks and approaches for the maintenance performance measurement (MPM) are also presented, where the emerging techniques like; emaintenance have also been discussed amongst others. More and more industries are applying the balanced and integrated MPM frameworks for their competitive survivability and sustainability.

Practical implications
– The concept, issues and approaches considered for the MPM frameworks can be adapted by the practicing managers, while trying to define and develop an MPM framework for the operation and maintenance activities. The considerations of the advantages and limitations of different frameworks can provide insights to the managers for implementation.

Originality/value
– Some literature reviews on MPM and MPM frameworks are available today. This paper makes an attempt to provide a detailed and relevant literature review, besides adding value in this new and emerging area.
External factors influencing the readiness for implementing public-private partnerships among public and private organizations in Yemen
Authors: Al-shareem Khaled Mohammed , Yusof Nor'Aini , Kamal Ernawati Mustafa 
Published: February 2015

Purpose– This paper aims to examine the external factors that influence the implementation of the new concept of public-private partnerships (PPPs) in Yemen.Design/methodology/approach– This study used a self-administered questionnaire that was distributed to Yemeni organizations. Data were analyzed using factor analysis, with appropriate tests of reliability, consistency, correlation and multiple regression analysis.Findings– The findings indicate that implementation of PPPs are affected through the government policies, market readiness and environmental uncertainty. The empirical evidence also suggests that government policies are the main predictor to PPPs implementation in Yemen. The proposed conceptual framework can be useful in developing PPPs implementation.Originality/value– This study contributes to the existing literature on PPPs by providing empirical evidence to identify the external factors that influence the readiness to implement PPPs. Furthermore, the study adds value through its contextual originality, given that this study is the first to empirically use the readiness theory in PPP implementation. Moreover, this paper describes the first attempt to investigate the implementation of PPPs in the context of Yemen.
Prevention of brachial plexus injury—12 years of shoulder dystocia training: an interrupted time‐series study
Authors: Crofts JF , Lenguerrand E , Bentham GL , Tawfik S , Claireaux HA , Odd D , Fox R , Draycott TJ 
Published: February 2015

ObjectiveTo investigate management and outcomes of incidences of shoulder dystocia in the 12 years following the introduction of an obstetric emergencies training programme.DesignInterrupted time‐series study comparing management and neonatal outcome of births complicated by shoulder dystocia over three 4‐year periods: (i) Pre‐training (1996–99), (ii) Early training (2001–04), and (iii) Late training (2009–12).SettingSouthmead Hospital, Bristol, UK, with approximately 6000 births per annum.PopulationInfants and their mothers who experienced shoulder dystocia.MethodA bi‐monthly multi‐professional 1‐day intrapartum emergencies training course, that included a 30‐minute practical session on shoulder dystocia management, commenced in 2000.Main OutcomesNeonatal morbidity (brachial plexus injury, humeral fracture, clavicular fracture, 5‐minute Apgar score <7) and documented management of shoulder dystocia (resolution manoeuvres performed, traction applied, head‐to‐body delivery interval).ResultsCompliance with national guidance improved with continued training. At least one recognised resolution manoeuvre was used in 99.8% (561/562) of cases of shoulder dystocia in the late training period, demonstrating a continued improvement from 46.3% (150/324, P < 0.001) pre‐training, and 92% (241/262, P < 0.001) in the early training period. In parallel there was reduction in the brachial plexus injury at birth (24/324 [7.4%, P < 0.01], pre‐training, 6/262 [2.3%] early training, and 7/562 [1.3%] late training.ConclusionsThere are significant benefits to long‐term, embedded training programmes with improvements in both management and outcomes. A decade after the introduction of training there were no cases of brachial plexus injury lasting over 12 months in 562 cases of shoulder dystocia.
A Grounded Guide to Gluten: How Modern Genotypes and Processing Impact Wheat Sensitivity
Authors: Kucek Lisa Kissing , Veenstra Lynn D. , Amnuaycheewa Plaimein , Sorrells Mark E. 
Published: February 2015

AbstractThe role of wheat, and particularly of gluten protein, in our diet has recently been scrutinized. This article provides a summary of the main pathologies related to wheat in the human body, including celiac disease, wheat allergy, nonceliac wheat sensitivity, fructose malabsorption, and irritable bowel syndrome. Differences in reactivity are discussed for ancient, heritage, and modern wheats. Due to large variability among species and genotypes, it might be feasible to select wheat varieties with lower amounts and fewer types of reactive prolamins and fructans. Einkorn is promising for producing fewer immunotoxic effects in a number of celiac research studies. Additionally, the impact of wheat processing methods on wheat sensitivity is reviewed. Research indicates that germination and fermentation technologies can effectively alter certain immunoreactive components. For individuals with wheat sensitivity, less‐reactive wheat products can slow down disease development and improve quality of life. While research has not proven causation in the increase in wheat sensitivity over the last decades, modern wheat processing may have increased exposure to immunoreactive compounds. More research is necessary to understand the influence of modern wheat cultivars on epidemiological change.
New Zealand Emergency Medicine Network: A collaboration for acute care research in New Zealand
Authors:   The New Zealand Emergency Medicine Network
Published: February 2015

AbstractThe specialty of emergency medicine in Australasia is coming of age. As part of this maturation there is a need for high‐quality evidence to inform practice. This article describes the development of the New Zealand Emergency Medicine Network, a collaboration of committed emergency care researchers who share the vision that New Zealand/Aotearoa will have a world‐leading, patient‐centred emergency care research network, which will improve emergency care for all, so that people coming to any ED in the country will have access to the same world‐class emergency care.
New agent to treat advanced or metastasized thyroid cancer, its efficacy, safety, and mechanism
Authors: Zhu Huan‐gao , Zhao Jun‐yu , Zhang Rui , Liao Lin , Dong Jian‐jun 
Published: February 2015

AbstractBackgroundVandetanib is the first US Food and Drug Administration approved agent to treat advanced or metastasized thyroid cancer. To gain a better understanding of the drug, we conducted a systematic review of its efficacy and safety in patients with thyroid cancers.MethodsTrial data was retrieved from Pubmed, EMBASE, Medline, China National Knowledge Infrastructure, and the Cochrane database without restrictions on language. A systematic review of the literature was performed to assess median progression‐free survival (PFS) and adverse events associated with vandetanib therapy for advanced or metastasized thyroid cancers.ResultsVandetanib statistically prolonged PFS in comparison with the placebo (30.5 vs. 19.3 months, hazard ratio 0.46), It even prolonged PFS in surgically unresectable or metastatic differentiated thyroid cancer cases compared with the placebo (11.1 vs. 5.9 months, hazard ratio 0.63). Rash, diarrhea, neutropenia, and hypertension were the most frequent side effects.ConclusionVandetanib can significantly improve PFS. Though it has some side effects, it is still a promising agent in the treatment of advanced or metastasized thyroid cancer, especially in those with metastasized or advanced medullary thyroid carcinoma.
Understanding gestational weight gain: the role of weight‐related expectations and knowledge
Authors: Mcphie Skye , Skouteris Helen , Hill Briony , Hayden Melissa 
Published: February 2015

BackgroundHealth behaviour theories acknowledge that beliefs, attitudes and knowledge contribute to health behaviours, yet the role of these cognitions in predicting weight gain during pregnancy has not been widely researched.AimsTo explore and compare the predictive nature of gestational weight gain (GWG) expectations and knowledge on weight gain during pregnancy.Materials and MethodsOne hundred and sixty‐six women were tracked during pregnancy. Participants provided information on prepregnancy weight, height, GWG expectations and knowledge at 16–18 weeks’ gestation (Time 1). To calculate gestational weight gain, prepregnancy weight was subtracted from weight at 36 weeks’ gestation (collected at Time 2). Gestational weight gain above the Institute of Medicine's GWG recommendations was classified as excessive. A hierarchical regression examined the predictive nature of GWG expectations for actual GWG. Chi‐square significance tests determined whether the accuracy of GWG knowledge differed depending on GWG status and prepregnancy BMI category.ResultsGWG expectations were a significant predictor of weight gain during pregnancy. Women who experienced excessive GWG were more likely to overestimate the minimum amount of weight that they needed to gain to have a healthy baby.ConclusionsGWG expectations are predictive of actual GWG, and GWG knowledge among women is generally poor. In particular, overestimating of the minimum amount of weight to gain during pregnancy is associated with excessive GWG. As such, it may be beneficial to design interventions to prevent excessive GWG that targets these cognitions.
Improving regional and rural cancer services in Western Australia
Authors: Platt Violet , O'Connor Kathleen , Coleman Rhonda 
Published: February 2015

AbstractObjectiveThis paper examines health reform which has been designed to improve cancer services across Western Australia.SettingWestern Australia is a large state divided into nine regions each with differing demographics. The diversity of the state and the distribution of the population over a large area of land create significant challenge in ensuring equality in service delivery.DesignA comparison was conducted looking at cancer services in Western Australia pre‐2005 and service delivery in 2014. A review of the partnership initiatives and programs provides a clear discussion on the need for coordination of care between service providers.Main OutcomeThe approach undertaken in Western Australia has seen an increase in the delivery of cancer services closer to the patient's home as well as greater involvement of primary care professionals in cancer care. This work has resulted in demonstrated improvements in patient care and support.ConclusionServices for cancer patients need to be accessible closer to home with distance being an appreciable barrier to treatment access.A statewide approach needs to be developed to ensure all people have equitable access to service delivery.
Reduced DNA methylation and hydroxymethylation in patients with systemic mastocytosis
Authors: Leoni Cristina , Montagner Sara , Deho' Lorenzo , D'Antuono Rocco , De Matteis Giovanna , Marzano Angelo V. , Merante Serena , Orlandi Ester M. , Zanotti Roberta , Monticelli Silvia 
Published: February 2015

AbstractObjectiveAs disruption of epigenetic control is a frequent event in solid tumors and leukemia, we investigated changes in DNA methylation (5mC) and hydroxymethylation (5hmC) in patients with systemic mastocytosis (SM), a rare myeloproliferative disease with a wide spectrum of severity, characterized by the accumulation of mast cells in various organs.MethodsWe measured overall genomic levels of 5hmC and 5mC in patients with SM by dot blot, as well as by quantitative immunofluorescence in samples of cutaneous mastocytosis.ResultsOverall 5hmC levels were reduced in all patients with SM, but to a greater extent in the presence of higher D816V mutational load in the KIT oncogene, which affects prognosis and therapeutic options in these patients. Loss of 5hmC was likely due to systemic effects of SM as it did not correlate with overall mast cell burden in these patients, nor it was due to inactivating mutations of TET2 or reduced TET2 expression.ConclusionsThe correlation between SM diagnosis and significantly low 5hmC levels suggests that reduction of 5hmC represents a systemic effect of SM that may be useful for patient stratification and that measurements of 5hmC levels may serve as a better prognostic marker than TET2 mutations.
Carbon balance indicator for forest bioenergy scenarios
Authors: Pingoud Kim , Ekholm Tommi , Soimakallio Sampo , Helin Tuomas 
Published: February 2015

AbstractA carbon (C) balance indicator is presented for the evaluation of forest bioenergy scenarios as a means to reduce greenhouse gas (GHG) emissions. A bioenergy‐intensive scenario with a greater harvest is compared to a baseline scenario. The relative carbon indicator (RC) is defined as the ratio between the difference in terrestrial C stocks – that is the C debt – and the difference in cumulative bioenergy harvest between the scenarios, over a selected time frame T. A value of zero indicates no C debt from additional biomass harvests, while a value of one indicates a C debt equal to the amount of additionally harvested biomass C. Multiplying the RC indicator by the smokestack emission factor of biomass (approximately 110 t CO2/TJ) provides the net cumulative CO2 emission factor of the biomass combustion as a function of T, allowing a direct comparison with the emission factors of comparable fossil fuels. The indicator is applied to bioenergy cases in Finland, where typically the rotation length of managed forests is long and the decay rate of harvest residues is slow. The country‐level examples illustrate that although Finnish forests remain as a C sink in each of the considered scenarios, the efforts of increasing forest bioenergy may still increase the atmospheric CO2 concentrations in comparison with the baseline scenario and use of fossil fuels. The results also show that the net emission factor depends – besides on forest‐growth or residue‐decay dynamics – on the timing and evolution of harvests as well. Unlike for the constant fossil C emission factor, the temporal profile of bioenergy use is of great importance for the net emission factor of biomass.
The association of CTLA‐4 A49G polymorphism with colorectal cancer risk in a Chinese Han population
Authors: Wang Y. , Wang X. , Zhao R. 
Published: February 2015

SummaryCytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) is expressed in T cells and plays an important role in the regulation of T cell. CTLA‐4 has long been considered to be associated with various kinds of diseases. With the attempt to examine the association between CTLA‐4 A49G polymorphism and colorectal cancer risk in a Chinese Han population, we employed TaqMan assay to genotype the CTLA‐4 A49G polymorphism in 311 colorectal cancer cases and 389 cancer‐free controls. We found evidence of the association between CTLA‐4 A49G polymorphism and colorectal cancer risk (GG vs. AA: OR = 2.01, 95% CI = 1.29–3.07, P = 0.002; GA vs. AA: OR = 2.32, 95% CI = 1.53–3.57, P = 0.001; GA + GG vs. AA: OR = 2.16, 95% CI = 1.46–3.21, P = 0.001). Next, we performed a meta‐analysis to comprehensively examine the association between CTLA‐4 A49G polymorphism and colorectal cancer risk. We found a significant association between CTLA‐4 A49G polymorphism and colorectal cancer risk among Asians, which is consistent with our result. However, we found no evidence for the association between CTLA‐4 A49G polymorphism and colorectal cancer risk among Caucasians. In conclusion, we demonstrated that the CTLA‐4 A49G polymorphism increased the susceptibility of colorectal cancer in Asian population.