bluuebunny/crossref_metadata_2025_split huggingface dataset:
Стратегічні напрями забезпечення енергетичної безпеки підприємств в період нестабільності
Authors: Чобіток Вікторія , Чобіток Ігор 
Published: July 2024

Нові трансформаційно-історичні умови вимагають переосмислення ролі та місця енергетичної безпеки підприємств в системі життєво важливих інтересів особи, суспільства, регіонів і держави в цілому. Аналіз структури таких складних і багатогранних явищ, як національна безпека, національні інтереси, ресурси підприємств, потребує розробки ефективного механізму захисту суб'єктів безпеки на всіх рівнях проти численних загроз і небезпек.
В турбулентних умовах, з урахуванням негативних впливів зовнішнього середовища (економічні кризи, пандемії, військові та політичні конфлікти, екологічні катастрофи, природні катаклізми тощо), перманентно генеруються та впроваджуються радикальні реформи, які охоплюють практично всі сторони діяльності вітчизняних підприємств, галузей та держави. Для вирішення цих завдань необхідно розробити стратегічні напрями забезпечення енергетичної безпеки підприємств в період нестабільності, які повинні базуватися на обґрунтуванні інноваційних векторів розвитку з урахуванням специфіки різних підсистем.
Процес переходу до сталого розвитку є глобальним, тому важливо скористатися перевагами розпочатого процесу глобалізації та спрямувати його економічну, енергетичну та соціальну складові, насамперед на реалізацію цілей сталого розвитку. Отже, процес глобалізації, що відбувається з ініціативи постіндустріальних країн, транснаціональних корпорацій і світових організацій, сприяв би переходу світової спільноти не до постіндустріального, а до сталого майбутнього всієї цивілізації.
Метою даної статті є формування стратегічних напрямів забезпечення енергетичної безпеки підприємств в період нестабільності.
В статті визначено, що при переході до сталого розвитку суспільства є ряд особливостей, завдяки яким вітчизняні підприємства можуть відігравати провідну роль у формуванні нової цивілізаційної моделі розвитку. Наразі важливо подолати системні кризи та знайти відносно стабільний та безпечний стан, з якого можна буде розпочати перехід на шлях сталого інноваційного та безпечного розвитку.
Авторами в статті проведено аналіз статистичних даних стосовно обсягу реалізованої промислової продукції за видами діяльності та постачанням електроенергії, газу, пари та кондиційованого повітря вітчизняними підприємствами за 2017-2023 рр.
В статті запропоноване стратегічно-орієнтоване підґрунтя забезпечення енергетичної безпеки підприємств в період нестабільності допоможе підприємствам забезпечити ефективну енергетичну безпеку, зменшити ризики і збільшити стійкість до зовнішніх впливів впливу.
Analisis Kualitas Dan Kepuasan Pengguna Website Istyle.id Dengan Metode Webqual 4.0
Authors: Andiati Astrid , R Shinta Oktaviana 
Published: July 2024

Pada zaman sekarang ini perkembangan teknologi informasi sudah berkembang pesat dalam penggunaan internet. PT. Indo Seungli Makmur adalah salah satu perusahaan yang bergerak di bidang e-commerce dan sebagai media untuk menjual barang kebutuhan secara online mereka menerapkannya pada sebuah situs website yang di terbitkan dengan nama Istyle.id. Sebuah website harus diukur berdasarkan kepuasan penggunanya agar dapat mengetahui seberapa puas pengguna dalam beraktivitas saat berbelanja di website istyle.id dengan menggunakan metode webqual 4.0. Dalam penelitian ini bertujuan untuk menguji pengaruh kegunaan (Usabilitiy), Kualitas Informasi (Information Quality), Kualitas Interaksi Pelayanan (Service Interaction Quality) disebut sebagai variabel independen/kegunaan dan untuk kepuasan pengguna dari keseluruhan (Overall Impression) disebut dengan variabel dependen. Sampel atau responden penelitian ini adalah pengguna website istyle.id. Untuk pengolahan data, menggunakan program SPSS dimana menguji instrumen penelitian dan model penelitian. Adapun teknik pengumpulan data menggunakan kuesioner yang dibagikan kepada responden sebanyak 50 orang Untuk mengetahui data yang didapatkan valid dan reliabel, dilanjutakan dengan uji asumsi klasik dimana ada 3 pengujian yaitu normalitas, multikolinieritas dan heteroskedastistas dan untuk mengetahui terjadi gejala atau tidak pada data, dan analisis regresi linier berganda untuk mengetahui variabel independen memiliki pengaruh dengan variabel dependen dengan uji F dan uji T. Diketahui bahwa variabel (usability), kualitas informasi (information quality), kualitas interaksi, pelayanan (service interaction quality) berpengaruh terhadap kepuasan pengguna, hasil yang didapati sebesar 46,5% atau belum cukup baik dikarenakan variabel kegunaan (usability), kualitas informasi (information quality), dan kualitas interaksi, pelayanan (service interaction quality) yang diketahui belum cukup baik pengaruhnya terhadap pengguna.
IMPLEMENTASI MODEL PEMBELAJARAN GENERATIF BERBASIS PETA KONSEP UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MATERI GETARAN HARMONIK DI SMAN 7 KOTA BENGKULU
Authors: Utami Shinta , Putri Desy Hanisa , Johan Henny 
Published: July 2024

ABSTRAK

Penelitian ini bertujuan untuk mendeskripsikan peningkatan hasil belajar siswa pada ranah kognitif. Jenis penelitian ini adalah Pre- Experiment dengan tipe One Group Pretest-Posttest design. Populasi penelitian adalah siswa kelas X MIPA SMAN 7 Kota Bengkulu tahun ajaran 2021/2022. Sampel penelitian dipilih dengan teknik random sampling sebanyak 33 siswa. Instrumen penelitian yang digunakan adalah observasi, wawancara, tes tertulis pilihan ganda dan angket respon peserta didik. Hasil penelitian ini dari perhitungan N-Gain menunjukkan nilai skor sebesar 0,50 dengan kategori sedang. Rerata persentase untuk hasil angket respon siswa menunjukkan sebesar 82,5% dengan kategori mendapatkan respon positif peserta didik terhadap penerapan perangkat pembelajaran fisika menggunakan model pembelajaran generatif berbasis peta konsep. Uji paired sample t-test memperoleh hasil tingkat signifikansi 0,000 < 0,05 yang artinya bahwa antara pretest dan posttest mengalami perbedaan yang signifikan. Berdasarkan hasil beberapa uji yang dilakukan maka dapat disimpulkan bahwa implementasi model pembelajaran generatif berbasis peta konsep pada materi getaran harmonik dapat meningkatkan hasil belajar siswa kelas X MIPA di SMAN 7 Kota Bengkulu.

Kata kunci : Hasil Belajar, Model Pembelajaran Generatif, Peta Konsep

ABSTRACT

This research aimed to describe the improvement of student learning outcomes in the cognitive domain. This type of research is Pre-Experiment with the type of One Group Pretest-Posttest design. The population of this research is the students of class X MIPA SMAN 7 Bengkulu City in the academic year 2021/2022. The research sample was selected by random sampling technique as many as 33 students. The research instruments used were observation, interviews, multiple choice written tests and student response questionnaires. The results of this study from the N-Gain calculation show a score of 0.50 in the medium category. The average percentage for the results of the student response questionnaire showed 82,5% with the category of getting a positive response from students towards the application of physics learning tools using a generative learning model based on concept maps. Paired sample t-test results obtained a significance level of 0.000 <0.05, which means that there is a significant difference between the pretest and posttest. Based on the results of several tests conducted, it can be concluded that the implementation of a generative learning model based on concept maps on harmonic vibration material can improve the learning outcomes of class X MIPA students at SMAN 7 Bengkulu City.

Keywords : Learning Outcomes, Generative Learning Model, Concept Map
IDENTIFIKASI JENIS DAN PEMANFAATAN BAMBU DI DESA REMBITAN KECAMATAN PUJUT KABUPATEN LOMBOK TENGAH
Authors: Lembusora Lembusora , Ratnaningsih Yulia 
Published: July 2024

Masyarakat desa Rambitan telah lama memanfaatkan tanaman bambu yang tumbuh disekitar wilayah mereka. Akan tetapi sebagian warga masyarakat Desa Rembitan masih ada yang belum mengetahui seberapa banyak jenis serta pemanfaatan dari bambu tersebut. oleh karena itu penelitian ini bertujuan untuk melakukan identifikasi jenis dan pemanfaatan bambu di desa Rambitan. Penelitian ini merupakan penelitian deskriptif. Data yang digunakan meliputi data primer dan sekunder. Teknik pengambilan sampel yang digunakan adalah teknik Snowball sampling. Ditemukan 8 jenis bambu di Desa Rembitan, Kecamatan Pujut, Kabupaten Lombok Tengah, jenis bambu tersebut yaitu : bambu petung (Dendrocalamus asper) , bambu ampel (Bambusa vulgaris), bambu tamiang (Schizostachyum brachycladum), bambu kuning (Bambusa vulgaris schard ), bambu tali (Gigantochloa apus), bambu tutul (Bambusa maculata), bambu tulup (Bambusa multiplex), dan bambu duri (Bambusa blumeana ). Masyarakat Desa Rembitan memanfaatkan bambu untuk pagar, berugak/ lasah, tiang antena, bahan bangunan, staiger, tangga, kandang sapi, kandang ayam, bethek, kurungan ayam, lantai dinding, hiasan rumah, mengambil rebungnya sebagai sayuran dan memanfaatkan daunya sebagai pembungkus nasi, sebagai alat pencuci panci dan digunakan untuk pemotongan hewan. Berdasarkan hasil penelitian tersebut terdapat 3 (tiga) pola pemasaran bambu yaitu: pengambil dan pengguna langsung, pengepul atau pedagang bambu dan pembeli atau pengguna bambu.
PELATIHAN ALAT PEMADAM API RINGAN DAN KARUNG GONI SEBAGAI MEDIA PEMADAMAN KEBAKARAN KEPADA MAHASISWA POLIBATAM, SISWA DAN GURU SMK DI BATAM
Authors: Wirawan Adhitomo , Mochtoha Himawan , Zainuddin Muhammad , Irsutami Irsutami , Fajrin Aulia , Akhnedi Andre , Russel Felix , Yessica Vinda , Ramadini Putri , Halim Shakila Lulu Fadillah , Budiman Budiman 
Published: July 2024

Fire disaster is one of the many disasters that occur in the wider community both in the office and residential environment. This fire disaster generally occurs due to human factors such as: using electrical loads that exceed the power capacity and placing flammable items near the source of fire. This fire hazard will be easier to overcome if people know how to put out fires properly and know how to use extinguishers such as APAR (Light Fire Extinguisher) and the use of gunny sacks. APAR is generally categorized into 3 types, namely: Dry Chemical Extinguisher, Carbon Dioxide (CO2) Extinguisher, and Foam. Extinguishers containing dry chemical powder are very commonly used because they are able to extinguish almost all types of fires. The use of APAR is most likely to be used because of its portable nature, easy maintenance, and easy to use. In the community service that has been carried out at Batam State Polytechnic, a demonstration on how to extinguish fire with fire extinguisher and the use of gunny sacks was also carried out. Participants of this community service program are students, vocational school students and vocational school teachers.
Bifidobacterium animalis subsp. lactis HN019 live probiotics and postbiotics: production strategies and bioactivity evaluation for potential therapeutic properties
Authors: D’ambrosio Sergio , Dabous Azza , Sadiq Saba , Casillo Angela , Schiraldi Chiara , Cassese Elisabetta , Bedini Emiliano , Corsaro Maria Michela , Cimini Donatella 
Published: July 2024

Introduction:B. animalis subsp. lactis HN019 is a commercially available well-characterized probiotic with documented effects on human health, such as the ability to enhance the immune function and to balance the intestinal microbiome. Therefore, optimizing the manufacturing process to improve sustainability, increasing biomass yields and viability, and avoiding animal -derived nutrients in the medium to meet vegan consumer’s needs, is currently of interest. Besides the established use of live probiotic cells, alternative supplements indicated as postbiotics, like non-viable cells and/or probiotics derived bioactive molecules might be considered as potential next generation biotherapeutics. In fact, advantages of postbiotics include fewer technological limitations, such as easier production processes and scale-up, and even higher specificity.Methods: In this work, medium design together with different fermentation strategies such as batch, fed-batch and in situ product removal on lab-scale bioreactors were combined. Medium pretreatment by ultrafiltration and protease digestion was performed to reduce polysaccharidic contaminants and facilitate the purification of secreted exopolysaccharides (EPS). The latter were isolated from the fermentation broth and characterized through NMR, GC-MS and SEC-TDA analyses. The expression of TLR-4, NF-kb and IL-6 in LPS challenged differentiated CaCo-2 cells treated with EPS, live and heat-killed B. lactis cells/broth, was evaluated in vitro by western blotting and ELISA. Zonulin was also assessed by immunofluorescence assays.Results and Discussion: The titer of viable B. lactis HN019 was increased up to 2.9 ± 0.1 x 1010 on an animal-free semidefined medium by applying an ISPR fermentation strategy. Medium pre-treatment and a simple downstream procedure enriched the representativity of the EPS recovered (87%), the composition of which revealed the presence of mannuronic acid among other sugars typically present in polysaccharides produced by bifidobacteria. The isolated EPS, live cells and whole heat inactivated broth were compared for the first up to date for their immunomodulatory and anti-inflammatory properties and for their ability to promote intestinal barrier integrity. Interestingly, EPS and live cells samples demonstrated immune-stimulating properties by downregulating the expression of TLR-4 and NF-kb, and the ability to promote restoring the integrity of the intestinal barrier by up-regulating the expression of zonulin, one of the tight junctions forming proteins. Postbiotics in the form of heat killed broth only reduced NF-kb expression, whereas they did not seem effective in the other tested conditions.
Assessing vaginal microbiome through Vaginal Microecology Evaluation System as a predictor for in vitro fertilization outcomes: a retrospective study
Authors: Tian Quan , Jin Shengxi , Zhang Guangmin , Liu Yujie , Liu Jianxin , Tang Xiuming , Li Yufeng , Liu Jiane , Liu Yifei , Wang Zheng 
Published: July 2024

ObjectiveThis study aims to evaluate the effectiveness of the Vaginal Microecology Evaluation System (VMES) in assessing the dynamics of the vaginal microbiome (VM) throughout the process of in vitro fertilization and embryo transfer (IVF-ET). Furthermore, it seeks to explore the potential correlation between distinct types of VM ecology and the success rate of IVF-ET.MethodsThis study employed VMES to ascertain the composition of the VM. Data were collected from infertile women who underwent their initial IVF-ET treatment for tubal factor between January 2018 and December 2021. A retrospective analysis of pregnancy outcomes resulting from their fresh embryo transfer was conducted to determine the predictive significance of the vaginal microenvironment.ResultsWe demonstrate that VMES is able to predict IVF-ET outcomes in patients diagnosed with Bacterial Vaginosis (BV). Notably, a discernible shift in the VM was observed in a decent subset of patients following Controlled Ovarian Stimulation (COS), though this phenomenon was not universal across all participants. Specifically, there was a noteworthy increase in the proportion of patients exhibiting BV and uncharacterized dysbiosis subsequent to COS. Furthermore, our investigation revealed a significant correlation between VM and both the live birth rate and early miscarriage rate. Employing a multivariable logistic regression model, we identified that VM status pre-COS, VM status post-COS, patient age, and the number of embryos transferred emerged as independent predictors of the live birth rate.ConclusionOur study suggests that, during IVF-ET treatment, the VMES can effectively detect changes in the VM, which are strongly correlated with the pregnancy outcome of IVF-ET procedures.
Neoadjuvant treatment with lenvatinib and pembrolizumab in a BRAF V600E-mutated anaplastic thyroid cancer: a case report
Authors: Barbaro Daniele , Forleo Raffaella , Profilo Maria Antonietta , Lapi Paola , Giani Carlotta , Torregrossa Liborio , Macerola Elisabetta , Materazzi Gabriele 
Published: July 2024

BackgroundTyrosine kinase inhibitors (TKIs) and immunotherapy have been proposed for advanced metastatic anaplastic thyroid cancer (ATC). We report a case of BRAF V600E-mutated ATC in which lenvatinib (L) plus pembrolizumab (P) enabled neoadjuvant treatment.Case presentationA male patient aged 65 years presented with a rapidly enlarging left latero-cervical mass. Fine needle aspiration was suggestive of ATC. Surgical consultation excluded radical surgery. While awaiting molecular profile analysis and considering the fast evolution of the disease, treatment with L and P was started. L was started at a dose of 14 mg daily, while P was started at the standard regimen (200 mg every 3 weeks). After 1 month, computerized tomography showed a reduction in the mass with almost complete colliquative degeneration, and the carotid artery wall was free from infiltration. Radical surgery was performed. Histology confirmed papillary thyroid cancer (PTC) in the left lobe and ATC with extensive necrosis in the left latero-cervical lymph node metastasis. The margins were free of tumors (R0). A BRAF V600E mutation was present in both PTC and ATC. At the 1-year follow-up, the patient was free of disease.ConclusionL and P in combination also appeared to be effective as a neoadjuvant treatment for BRAF V600E-mutated ATC. This combination treatment could be used when there is an opportunity for complete resection of the cancer, and as soon as possible. The intermediate dose of 14 mg of L appeared to be well tolerated and effective.
Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study
Authors: Zhu Guandong , Tian Ruikang , Zhou Dengke , Qin Xuejiao 
Published: July 2024

PurposeTo investigate the genetic correlation and causal links between sleep traits (including sleep duration, chronotype, and insomnia) and myopia.MethodsSummary data on three sleep traits (sleep duration, chronotype and insomnia) and myopia from FinnGen (n = 214,211) and UK Biobank (n = 460,536) were analyzed using linkage disequilibrium score regression (LD Score), univariable and multivariable mendelian randomization (MR) experiments and Causal Analysis Using Summary Effect (CAUSE) estimation.ResultsLD Score regression detected candidate genetic correlation between sleep traits and myopia, such as sleep duration, chronotype (Genetic Correlation Z-score &gt;10.00, h2_observed_p &lt; 0.005, Lambda GC &gt; 1.05, p &gt; 0.05). Univariable MR analyses indicated that increased sleep duration has a promotional effect on the occurrence of myopia (p = 0.046 &lt; 0.05, P_FDR = 0.138 &lt; 0.2, OR = 2.872, 95% CI: 1.018–8.101). However, after accounting for potential confounding factors, multivariable MR and CAUSE analysis did not provide evidence for a causal effect of the three sleep traits on myopia.ConclusionThere may be a potential genetic correlation between sleep duration, chronotype and myopia. However, neither of sleep duration, chronotype or insomnia had causal effect on myopia.
ATP-P2X7R pathway activation limits the Tfh cell compartment during pediatric RSV infection
Authors: Russo Constanza , Raiden Silvina , Algieri Silvia , Bruera María José , De Carli Norberto , Sarli Mariam , Cairoli Héctor , De Lillo Leonardo , Morales Ivanna , Seery Vanesa , Otero Adrián , Sananez Inés , Simaz Nancy , Alfiero Gisela , Rubino Gabriela , Moya Néstor , Aedo Portela Luisa , Herrero Mauro , Blanco Marina , Salcedo Pereira Misael , Ferrero Fernando , Geffner Jorge , Arruvito Lourdes 
Published: July 2024

BackgroundFollicular helper T cells (Tfh) are pivotal in B cell responses. Activation of the purinergic receptor P2X7 on Tfh cells regulates their activity. We investigated the ATP-P2X7R axis in circulating Tfh (cTfh) cells during Respiratory Syncytial Virus (RSV) infection.MethodsWe analyzed two cohorts: children with RSV infection (moderate, n=30; severe, n=21) and healthy children (n=23). We utilized ELISA to quantify the levels of PreF RSV protein-specific IgG antibodies, IL-21 cytokine, and soluble P2X7R (sP2X7R) in both plasma and nasopharyngeal aspirates (NPA). Additionally, luminometry was employed to determine ATP levels in plasma, NPA and supernatant culture. The frequency of cTfh cells, P2X7R expression, and plasmablasts were assessed by flow cytometry. To evaluate apoptosis, proliferation, and IL-21 production by cTfh cells, we cultured PBMCs in the presence of Bz-ATP and/or P2X7R antagonist (KN-62) and a flow cytometry analysis was performed.ResultsIn children with severe RSV disease, we observed diminished titers of neutralizing anti-PreF IgG antibodies. Additionally, severe infections, compared to moderate cases, were associated with fewer cTfh cells and reduced plasma levels of IL-21. Our investigation revealed dysregulation in the ATP-P2X7R pathway during RSV infection. This was characterized by elevated ATP levels in both plasma and NPA samples, increased expression of P2X7R on cTfh cells, lower levels of sP2X7R, and heightened ATP release from PBMCs upon stimulation, particularly evident in severe cases. Importantly, ATP exposure decreased cTfh proliferative response and IL-21 production, while promoting their apoptosis. The P2X7R antagonist KN-62 mitigated these effects. Furthermore, disease severity positively correlated with ATP levels in plasma and NPA samples and inversely correlated with cTfh frequency.ConclusionOur findings indicate that activation of the ATP-P2X7R pathway during RSV infection may contribute to limiting the cTfh cell compartment by promoting cell death and dysfunction, ultimately leading to increased disease severity.
Donor-derived cell-free DNA predicted allograft rejection and severe microvascular inflammation in kidney transplant recipients
Authors: Kim Hyung Duk , Bae Hyunjoo , Kang Hyunhye , Lee Hanbi , Eum Sang Hun , Yang Chul Woo , Choi Yeong Jin , Chung Byung Ha , Oh Eun-Jee 
Published: July 2024

IntroductionThe aim of this study is to investigate the clinical validity of donor-derived cell-free DNA (dd-cfDNA) in comparison with that of donor specific anti-HLA antibody (DSA) for predicting biopsy-proven rejection (BPR)and severe microvascular inflammation (severe MVI) in kidney transplant recipients (KTRs).MethodsIn this prospective observational investigation, 64 KTRs who underwent the indicated biopsies were included. Blood samples collected prior to biopsy were tested for dd-cfDNA and DSA. Biopsy specimens were classified by a renal pathologist according to the Banff classification. The predictive performance of dd-cfDNA and DSA for histological allograft diagnosis was assessed.ResultsKTRs were categorized into the high and low dd-cfDNA groups based on a level of 0.4%. Eighteen patients (28.1%) had positive DSA at biopsy, exhibiting higher dd-cfDNA levels than the DSA-negative patients. BPR and severe MVI incidences were elevated in the high dd-cfDNA group (BPR: 42.9% vs. 3.4%, P &lt;0.001; severe MVI: 37.1% vs. 3.4%, P = 0.001). Also, elevated glomerulitis and MVI scores were observed in the high dd-cfDNA group. DSA showed the highest predictive value for BPR (AUC = 0.880), whereas dd-cfDNA alone excelled in predicting severe MVI (AUC = 0.855). Combination of DSA and dd-cfDNA (&gt;0.4%) yielded sensitivities of 80.0% and 50.0% with specificities of 90.7% and 88.0% for antibody-mediated rejection and severe MVI detection, respectively.ConclusionThe dd-cfDNA test is a predictive tool for BPR and severe MVI, and it can improve the performance, especially when combined with DSA for BPR.