bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increase in Testosterone Levels and Improvement of Clinical Symptoms in Eugonadic men With a Prolactin-secreting Adenoma
Authors: Carlier Lea , Chanson Philippe , Cazabat Laure , Daclin Sylvie , Salenave Sylvie , Hage Mirella , Trabado Séverine , Young Jacques , Maione Luigi 
Published: July 2024

Abstract

Objective
Testosterone concentrations, albeit rarely, may be in the normal range (&gt;3.0 ng/mL) in men with a prolactin-secreting pituitary adenoma (PSPA-nt). The evolution of total, bioavailable testosterone, gonadotropin levels, and that of graded symptoms of testosterone deficiency (TD) are uncertain in these patients.

Design
Retrospective case-control longitudinal study at a tertiary referral center.

Methods
From 287 men, we selected 25 PSPA-nt men undergoing prolactin normalization (&lt;20.0 ng/mL) during the follow-up. Graded symptoms of TD were investigated by structured interviews. Biochemical changes and TD symptoms were compared to those of a matched cohort of 61 men with pituitary neoplasms and normal testosterone levels (PA-nt).

Results
Baseline testosterone levels were similar between PSPA-nt and PA-nt subjects. The prevalence of specific and suggestive symptoms of TD was higher in PSPA-nt (20% and 68%) than in PAnt (3.3 and 29.5%; P = .02 and P = .0015, respectively). At the follow-up, total and bioavailable testosterone levels increased in PSPA-nt but not in PA-nt patients (Δ change: 1.28 ± 2.1 vs0.03 ± 1.5 ng/mL, + 0.33 ± 0.55 vs-0.26 ± 0.60 ng/mL; P = .0028 and P = .0088, respectively). LH and FSH levels also increased in PSPA-nt men (P &lt; .05). Specific and suggestive, but not nonspecific symptoms of TD, improved only in PSPA-nt men (P &lt; .05 for both). Baseline testosterone and LH were the strongest predictors of testosterone improvement in PSPA-nt patients.

Conclusion
Despite having normal testosterone levels at baseline, patients with PSPA-nt experience a relief of TD symptoms and an improvement of their pituitary-gonadal axis function following prolactin normalization, especially when baseline TT and LH levels are in the low-normal range.
Who Divorces Whom: Unilateral Divorce Legislation and the Educational Structure of Marriage
Authors: Afunts Geghetsik , Jurajda Stepan 
Published: July 2024

AbstractThe introduction of unilateral divorce legislation (UDL) starting in the late 1960s led to spikes in U.S. divorce rates. We ask whether making divorce easier affected the educational structure of marriage. Using marriage and divorce certificate data covering 1970–1988, we provide new evidence on the evolution of the educational structure of marriage inflows (newlyweds) and outflows (divorces). Next, we leverage the timing of UDL introduction across states to estimate its effects on both flows. We find that UDL affected the educational structure of divorce but not of new marriages: it made generally unstable hypogamous couples (women married to less educated partners) less likely to divorce and made homogamous couples more stable than hypergamous ones (women married to more educated partners).
Ho‘ailona
Authors: Otjen Nathaniel 
Published: July 2024

Abstract
This article asks what it means for conservation scientists to label a member of an endangered, endemic species homeless. By considering the boundary-crossing figure of Ho‘ailona, a partially blind Hawaiian monk seal who was declared homeless and translocated six times between 2008 and 2009, the article argues that the language of home points to the ongoing operations of colonialism in Western conservation. Reading the discourse of homelessness offers a methodology for tracing the histories and manifestations of colonial logics as they circulate in conservation science. At the same time, the article considers how Kānaka Maoli articulated a contrapuntal claim to home that positioned Ho‘ailona as belonging in his natal waters and among a multispecies community of caregivers. Bringing together critical homelessness studies and settler colonial studies, the essay examines how settler societies and institutions use endangered marine species to make specific claims to home and, by extension, erase Indigenous claims to place.
Uncertain Waters and Irony in Australian Settler Literatures
Authors: Shewry Teresa , Steer Philip 
Published: July 2024

Abstract
Critics are increasingly recognizing the presence of irony in environmental cultures, often stressing its ability to highlight disjunctions between the individual’s convictions and their compromised behaviors. This article extends this work by taking up the relationship between irony and settler-colonial imaginaries in writings about unpredictable bodies of water. Focusing on settler writing in Australia, the article juxtaposes nineteenth-century author Henry Lawson and contemporary novelist Jane Rawson to argue that irony constitutes a form of environmental knowledge, calling up norms and hierarchies regarding water but also creating openings toward waters that cannot be given meaning. Lawson’s writings about ephemeral rivers and lakes stress their divergence from metropolitan ideas of water’s continuity, presence, and visibility. Largely ignoring Indigenous peoples’ relationships with water, his ironies of overturned expectations and norms make contact with but also disparage water in unfamiliar forms. By contrast, Rawson’s A Wrong Turn at the Office of Unmade Lists (2013) employs irony to grasp how climate-changed floodwater disrupts settler norms founded upon the erasure of floodplains and of Indigenous and colonial histories of urban rivers. Juxtaposing Rawson with Lawson illuminates an ongoing need to be cautious about the ideals that irony may evoke in response to changing and uncertain waters. At the same time, irony provides a multivalent tool to critically address what Mark Rifkin calls “settler common sense,” to glimpse the persistence of Indigenous knowledge and perspectives, and to acknowledge occluded forms of environmental agency.
La influencia de los tipos de contrato sobre el valor de las ventas en las empresas manufactureras colombianas
Authors: Beltrán-Díaz Albeiro , Hernández-Fernández Lissette , Gallardo-Figueroa Silvia Paola , Espitia-González Sandra Marcela 
Published: July 2024

Objetivo: Analizar la relación entre el tipo de contrato laboral y los ingresos que generan las empresas manufactureras colombianas. Metodología: Para el desarrollo de la investigación se realizó un estudio con enfoque cuantitativo, de tipo no experimental, transversal y correlacional, para el que se tomó como insumo la Encuesta Anual Manufacturera 2019, publicada por el Departamento Administrativo Nacional de Estadísticas (DANE), conformada por 7 631 empresas. Resultados principales: Los resultados permiten reflexionar sobre la importancia y el especial cuidado que los gerentes deben tener con el tipo de contrato que utilizan para vincular a sus trabajadores, principalmente en momentos de incertidumbre política y económica, donde los empresarios pueden optar por reducir sus costos mediante la vinculación con contratos de prestación de servicios que otorgan menos beneficios laborales y obligan a los trabajadores a pagar de sus ingresos los aportes a salud y pensión, sin derecho a vacaciones pagas, primas ni cesantías. Conclusiones: El estudio concluye que los ingresos de las empresas pueden mejorarse si se vincula al personal mediante contratos temporales con bolsas de empleo y contratos a término indefinido directamente con la empresa; los contratos a término fijo directos con la empresa reducen los ingresos de la misma.
Patient and public involvement in liver disease management and research: insights into the development of a patient group
Authors: Grønkjær Lea Ladegaard , Lauridsen Mette Munk 
Published: July 2024

Background: Patient and public involvement (PPI) is increasingly recognised as crucial for enhancing healthcare and research relevance. This case study aimed to describe the development of a PPI group within the context of liver disease management and research, highlighting opportunities and challenges encountered. Methods: Patients with liver disease were recruited from a gastroenterology department through an online survey. An initial group discussion meeting was held using a nominal group technique, focusing on establishing the group's purpose, identifying areas of interest for involvement and determining practical organisational aspects. Ongoing collaboration occurred through regular meetings and communication. Results: A total of 18 patients actively participated in the group. Their motivations included utilising lived experiences to support others, gain knowledge about liver disease and raise public awareness. The group contributed to developing patient information, nurse-led consultations and a patient application. Additionally, they identified a need for research on improving healthcare system pathways for liver disease patients. Conclusions: This case study demonstrates a sustainable model for PPI in liver disease. Opportunities included empowering patients as consultants, collaborators and potential patient-led researchers. Challenges included addressing diversity within the group and ensuring adequate resources for PPI activities. This study provides valuable insights for healthcare professionals and researchers seeking to implement PPI in their own settings.
Prevalence of hepatitis B virus infection among pregnant women in Africa: A systematic review and meta-analysis
Authors: Larebo Yilma Markos , Anshebo Abebe Alemu , Abdo Ritbano Ahmed , Behera Sujit Kumar , Gopalan Natarajan 
Published: July 2024

Introduction
Africa exhibits a considerably high prevalence of the hepatitis B virus among pregnant women. Furthermore, there is a discernible lack of a well-established surveillance system to adequately monitor and comprehend the epidemiology of the hepatitis B virus, particularly among pregnant women. The eradication efforts of the virus in Africa have been impeded by the significant disease burden in the region, and there is a lack of evidence regarding the pooled prevalence of the hepatitis B virus in Africa. Consequently, this systematic review and meta-analysis aims to determine the prevalence of hepatitis B virus infection among pregnant women in Africa.

Methods
We conducted a systematic literature search using reputable databases such as PubMed, Advanced Google Scholar, Scopus, and the Cochrane Library. The search spanned from July 2013 to July 2023 and included all relevant articles published within this period. To identify potentially eligible articles, we conducted a comprehensive manual review of the reference lists of the identified studies. Our review encompassed articles from the African Journal Online. The analysis focused on observational studies published in peer-reviewed journals that reported the prevalence of hepatitis B surface antigen-positive testing among pregnant women. We utilized the Newcastle-Ottawa critical appraisal checklist to assess the methodological quality of each paper. Finally, a meta-analysis was conducted using a random-effects model.

Results
Out of the 774 studies identified, 31 studies involving 33,967 pregnant women were selected for the meta-analysis. According to the random-effects model, the combined prevalence of hepatitis B virus among pregnant women was 6.77% [95% CI: 5.72, 7.83]. The I2 statistic was calculated to be 95.57% (p = 0.00), indicating significant heterogeneity among the studies. The high I2 value of 95.57% suggests a substantial degree of heterogeneity. A subgroup meta-analysis revealed that factors such as time-dependent bias, sample size dependence, or individual variation among study participants contributed to this heterogeneity (p-difference < 0.05).

Conclusion
According to the findings of this study, the pooled prevalence of hepatitis B infection among pregnant women in Africa was found to be intermediate-high. It is recommended that policymakers implement hepatitis B virus immunization programs targeting pregnant women and their new-born babies at higher risk of exposure.
CRY2 mediates the cognitive decline induced by sleep deprivation in 5xFAD mice
Authors: Luo Sumei , Guo Lizhe , Chen Na , Guo Qulian , Xie Yongqiu , Wang Yunjiao , Wang E. 
Published: July 2024

Background
Cryptochrome-2 (CRY2) is a core rhythm gene that plays a crucial role in DNA damage repair. The present study investigated the potential role of CRY2 in mediating sleep deprivation-induced cognitive decline in 5xFAD mice.

Methods
To assess the effects of SD on different brain regions of the mouse brain, we used 18F FDG PET-CT. Cognitive function was evaluated using the Morris water maze test and Y-maze. Lentivirus was used for the overexpression of CRY2, and small interfering RNA (siRNA) was used for the downregulation of CRY2 to verify the effect of CRY2. We used qRT‒PCR and Western blotting to identify the downstream factors of CRY2 and evaluated the cognitive function of mice to confirm the effects of these factors.

Results
The AD mice exhibited cognitive decline after 21 days of SD and had higher expression of CRY2 compared to AD mice with normal sleep. Overexpression of CRY2 led to decreased cognitive function in AD mice, and the downregulation of CRY2 attenuated the SD-induced cognitive decline in AD mice. CRY2 reduced the expression and function of CISH, which reduced the inhibition of STAT1 phosphorylation and led to synaptic dysfunction. CISH overexpression attenuated the impairing effect of sleep deprivation on cognitive function in AD mice. Furthermore, 18F FDG PET-CT revealed that SD significantly reduced glucose metabolism in different brain regions of AD mice.

Conclusion
Our study demonstrated that sleep deprivation upregulated CRY2 in the hippocampus of AD mice, which resulted in synaptic dysfunction by decreasing CISH-mediated STAT1 phosphorylation.
Effect of inspiratory muscle training in esophageal cancer patients receiving esophagectomy: A meta-analysis of randomized controlled trials
Authors: Su Jianhua , Huang Wei , Yu Pengming 
Published: July 2024

Purpose
To identify the clinical effect of inspiratory muscle training (IMT) among esophageal cancer patients undergoing esophagectomy based on randomized controlled trials (RCTs).

Methods
Several databases were searched for relevant RCTs up to August 23, 2023. Primary outcomes were respiratory muscle function, including the maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP), and pulmonary function, including the forced expiratory volume in one second % (FEV1%), forced vital capacity% (FVC%), maximal ventilator volume (MVV), FEV1/FVC% and FVC. The secondary outcomes were exercise performance, including the six-minute walk distance test (6MWT) and Borg index; mental function and quality of life, as evaluated by the Hospital Anxiety Depression Scale (HADS) and Nottingham Health Profile (NHP) score; and postoperative complications. All the statistical analyses were performed with REVMAN 5.3 software.

Results
Eight RCTs were included in this meta-analysis, with 368 patients receiving IMT and 371 control subjects. The pooled results demonstrated that IMT could significantly enhance respiratory muscle function (MIP: MD = 7.14 cmH2O, P = 0.006; MEP: MD = 8.15 cmH2O, P<0.001) and pulmonary function (FEV1%: MD = 6.15%, P<0.001; FVC%: MD = 4.65%, P<0.001; MVV: MD = 8.66 L, P<0.001; FEV1/FVC%: MD = 5.27%, P = 0.03; FVC: MD = 0.50 L, P<0.001). Furthermore, IMT improved exercise performance (6MWT: MD = 66.99 m, P = 0.02; Borg index: MD = -1.09, P<0.001), mental function and quality of life (HADS anxiety score: MD = -2.26, P<0.001; HADS depression score: MD = -1.34, P<0.001; NHP total score: MD = -48.76, P<0.001). However, IMT did not significantly decrease the incidence of postoperative complications.

Conclusion
IMT improves clinical outcomes, such as respiratory muscle function and pulmonary function, in esophageal cancer patients receiving esophagectomy and has potential for broad applications in the clinic.
Prevalence of chronic kidney disease in patients with type 2 diabetes admitted to multidisciplinary hospitals: results of a prospective observational multicenter study (CREDO)
Authors: Antsiferov M. B. , Kotenko O. N. , Kobalava Z. D. , Demidova T. Y. , Markova T. N. , Tolkacheva V. V. , Morgunov L. Y. , Andreeva A. V. , Pashkova E. Y. , Khaziakhmetova M. R. , Samburova E. S. , Vedyashkina S. G. , Mkrtumyan A. M. , Petunina N. А. , Serebrov А. N. , Deeva T. M. , Karaeva A. Y. 
Published: July 2024

AIM: To assess the prevalence of chronic kidney disease (CKD), clinical and demographic characteristics and therapy profile in patients with type 2 diabetes admitted to multidisciplinary hospitals. CREDO (Cardio-REnal Diabetic cOmplications) trial was initiated for this purpose.MATERIALS AND METHODS: in a prospective observational multicenter study for the period from August 2022 to April 2023, data from 445 patients with type 2 diabetes hospitalized in multidisciplinary hospitals of the Moscow Department of Health were analyzed. The data was collected on a single visit. The design of the study did not involve any interventions in routine clinical practice, including the choice of a diagnostic or treatment method.RESULTS. The study included 445 patients with the main inclusion criteria — type 2 diabetes, age over 50 years, duration of diabetes more than 3 years. The prevalence of CKD was 90%, while in 43% the diagnosis of CKD was confirmed, in 43% it was detected for the first time, and in 7% the disease progressed. Patients with stage C2 and C3 (a and b), as well as with levels of A1 and A2 albuminuria, were most often identified. The percentage of patients in whom the albuminuria was not performed remained high — 46.2%. The highest incidence of CKD was observed in patients with inadequate glycemic control, having an HbA1c level of ≥9%. In the group with newly diagnosed CKD, sodium-glucose co-transporter-2 inhibitor (iSGLT-2) was received by 31.1% of patients, glucagon-like peptide-1 receptor agonists (GLP-1 RA) — 7.9% of patients. In the group with confirmed CKD — 30.7% and 9.4%, respectively.CONCLUSION: it has been shown that patients over the age of 50 with type 2 diabetes with a disease duration of more than 3 years are at a high risk of developing CKD — 90%. The results obtained convincingly confirm the possibility of detecting CKD and initiating nephroprotective therapy at the hospital stage.
Clinical decision support system based on artificial intelligence for adjusting insulin pump parameters in children with type 1 diabetes mellitus
Authors: Sorokin D. Yu. , Trufanova E. S. , Rebrova O. Yu. , Bezlepkina O. B. , Laptev D. N. 
Published: July 2024

BACKGROUND: Widely available diabetes devices (continuous glucose monitoring, insulin pump etc.) generate large amount of data and development of an advanced clinical decision support system (CDSS), able to automatically evaluate and optimize insulin therapy, is relevant.AIM: Development of a mathematical model and an CDSS based on it to optimize insulin therapy in children with type 1 diabetes (T1D) and assessment of the agreement between the recommendations of the CDSS and the physician on insulin pump (IP) parameters: basal profile (BP), carbohydrate ratio (CR), correction factor (СF).MATERIALS AND METHODS: Data from 504 children with T1DM were analyzed over the period of 7875 days. The data included glucose, insulin, food, sex, age, height, weight, diabetes duration and HbA1c. We constructed recurrent neural network (RNN) to predict glucose concentration for 30-120 minutes, an algorithm for optimizing IP settings using prediction results. Next, a software product was developed — a CDSS. To assess the agreement of the recommendations of the CDSS and physicians, retrospective data from 40 remote telemedicine consultations of 40 patients with T1D (median age 11.6 years [7; 15]) were used and 960 points of possible adjustments were analyzed. Three degrees of agreement have been introduced: complete agreement, partial agreement, and complete disagreement. The magnitude of the adjustments was also analyzed.RESULTS: The accuracy of glycemic predictions was better or comparable with other similar models. The assessment of agreement for BP, CR and CF, according to the Kappa index, showed slight and weak agreement. The frequency of complete agreement between recommendations for adjusting the ongoing IP therapy between the CDSS and physicians is 37.5–53.8%, and complete inconsistency is 4.5–17.4%. From a clinical point of view, consistency in the frequency of occurrence of the indicator is more important. There were no differences in median IP settings between the CDSS and physicians.CONCLUSION: The CDSS has an acceptable accuracy of glycemic predictions. The CDSS and physicians provide comparable recommendations regarding CSII parameters.
Fertilizer application parameters for drip-irrigated peanut based on the fertilizer effect function established from a “3414” field trial
Authors: Gao Zhijian , Bai Xinlu , Tang Xiaoyun , Zhi Jinhu , Liu Yu , Wang Guodong , Yang Guojiang , Liu Yantao , Wang Liang 
Published: July 2024

Abstract
Scientific fertilization is an important technical means of achieving high and stable peanut yields. Using soil testing and formula fertilization, the “3414” optimal regression design was used and included 14 nitrogen (N), phosphorus (P), and potassium (K) fertilization treatments. Ternary quadratic functions of the fertilizer effect were established according to three-season field experiments and the regression analysis of fertilizer–yield function was performed to explore the optimal fertilizer application mode and ratio for peanuts under mulched drip irrigation (MDI), and a suitable fertilizer application system was established. The ternary quadratic equation relating peanut yield (y) and the fertilizer application rates of N (N), P (P2O5), and K (K2O) was obtained after fitting, i.e., y = 2912.528 + 21.432N + 16.324P + 6.181K − 0.051N2 − 0.109P2 − 0.061K2 + 0.017NP + 0.023NK + 0.086PK, and significance analysis and typicality assessment were performed. The model R
2 was 0.9709, both values are extremely significant (p < 0.01), which indicates that the obtained ternary quadratic fertilizer effect function is typical and could be used for statistical purposes and fertilization recommendations. Three quadratic fertilizer effect functions were obtained. Among them, the equation for K is extremely significant, and the equations of N and P are significant. According to the assumption that the marginal yield is zero and the marginal profit is zero, the fertilizer application rate with the maximum yield, the fertilizer application rate with the best economic benefits, and the corresponding yields were obtained. The optimal fertilizer application rate predicted by the ternary quadratic fertilizer effect function was relatively high, so the three quadratic fertilizer effect functions were used for prediction. Under the test conditions, the recommended fertilizer application rates for peanuts under MDI are 256.6 kg N per ha, 164.2 kg P2O5 per ha, and 213.2 kg K2O per ha, the recommended fertilization ratio is 1:0.64:0.83, and the recommended ratio under formula fertilization is 23:15:19. The study has developed a data-based decision support system for Xinjiang drip-irrigated peanut, which assists farmers and agricultural managers in making more scientific and precise fertilization decisions based on the specific growth requirements of the crops and soil conditions. This evidence-based methodology enhances the precision of agricultural management, which is conducive to increasing crop yields while reducing resource wastage and environmental impact. However, multipoint and multiyear experiments are still needed to ensure that the findings are adaptable to the diverse soil conditions and fluctuating climate patterns that may be encountered in practice.