bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of empagliflozin in the treatment of Malaysian patients with chronic heart failure and preserved or mildly reduced ejection fraction
Authors: Tan Yi Jing , Linden Stephan , Ong Siew Chin 
Published: August 2024

Introduction
Empagliflozin demonstrates promising clinical benefits in patients with heart failure (HF). While an early study demonstrates that empagliflozin is cost-effective for treating HF patients with reduced ejection fraction (HFrEF) in Malaysia, its cost-effectiveness for HF with ejection fraction (EF)>40% remains unclear. Therefore, the current study aimed to assess the cost-effectiveness of adding empagliflozin to the standard of care (SoC) for HF patients with EF>40% from the perspective of Malaysian healthcare system. Subsequently, the results were consolidated with the findings for HFrEF to evaluate the cost-effectiveness of empagliflozin when used for all HF patients in Malaysia, irrespective of EF.

Methods
A cost-utility analysis was performed using a validated Markov model, which modelled a cohort of adult patients through health states related to symptom severity and functional impairment, to estimate costs and quality-adjusted life-years (QALYs). The influence of model inputs and assumptions, sensitivity, scenario, and subgroup analyses were explored. All costs were expressed in 2022 Malaysian ringgits (RM). Costs and QALYs were discounted at an annual rate of 3.0% as per local pharmacoeconomic guideline.

Results
The base-case incremental cost-effectiveness ratio (ICER) for HF patients with EF>40% was RM 40,454 per QALY gained. At a cost-effectiveness threshold of RM 47,439/QALY gained, empagliflozin was cost-effective in 57% of replications. The model outcomes were sensitive to inputs related to the treatment effect of empagliflozin in reducing HF-related hospitalisation and cardiovascular mortality, and empagliflozin cost. For the overall HF population, the ICER was RM 29,463/QALY gained.

Conclusion
The findings suggest that empagliflozin is a cost-effective treatment option for the Malaysian HF population, including those with EF>40%. As such, the intervention warrants consideration by the Malaysian healthcare provider to mitigate the burden of HF and address the unmet needs of the EF>40% population.
A qualitative exploration of migraine in students attending Irish Universities
Authors: Flynn Orla , Blake Catherine , Fullen Brona M. 
Published: August 2024

Introduction
The complex neurological disorder of migraine is prevalent (19%) and burdensome in university students. Qualitative research exploring the lived experience of migraine in students has yet to be conducted.

Methods
Students clinically diagnosed with migraine were recruited (purposive sampling) from a sample of Irish third-level institutions for a one-time anonymized Zoom focus group or individual interview. Focus group questions were sent to participants in advance. Interviews were iterative. Participants were also invited to submit a drawing. The interviews were audio-recorded, transcribed, and sent to participants for triangulation. Reflexive thematic content analysis was undertaken, data was imported to Microsoft Excel, initial codes were generated, and themes and sub-themes were derived from the codes. The Standards for Reporting Qualitative Studies Checklist (S1 File) ensured study rigour.

Results
Twenty students from three Irish universities participated (mean age 23.8 years). The four key themes identified were (i) Migraine Characteristics, (ii) Migraine Self-Management, (iii) Migraine Clinical Management, and (iii) Migraine Impacts. Migraine was described as not just a headache but a debilitating sensory experience. A notable high level of self-management satisfaction indicated hopeful coping strategies. However, many participants said medications were ineffective and had side effects, and clinical management could be improved. Additionally, there was a marked academic and social impact of migraine, psychological issues abounded, and several participants worried about finances.

Conclusions
Migraine is impactful in a cohort of students attending Irish third-level institutions, with students carrying a wide range of debilitating migraine burdens. Students demonstrate an attitude of resilience and determination despite these challenges. Migraine awareness and education campaigns on university campuses are warranted.
Use of extracellular vesicle microRNA profiles in patients with acute myeloid leukemia for the identification of novel biomarkers
Authors: Kang Ka-Won , Gim Jeong-An , Hong Sunghoi , Kim Hyun Koo , Choi Yeonho , Park Ji-ho , Park Yong 
Published: August 2024

Objectives
This study aimed to establish clinically significant microRNA (miRNA) sets using extracellular vesicles (EVs) from bone marrow (BM) aspirates of patients with acute myelogenous leukemia (AML), and to identify the genes that interact with these EV-derived miRNAs in AML.

Materials and methods
BM aspirates were collected from 32 patients with AML at the time of AML diagnosis. EVs were isolated using size-exclusion chromatography. A total of 965 EV-derived miRNAs were identified in all the samples.

Results
We analyzed the expression levels of these EV-derived miRNAs of the favorable (n = 10) and non-favorable (n = 22) risk groups; we identified 32 differentially expressed EV-derived miRNAs in the non-favorable risk group. The correlation of these miRNAs with risk stratification and patient survival was analyzed using the information of patients with AML from The Cancer Genome Atlas (TCGA) database. Of the miRNAs with downregulated expression in the non-favorable risk group, hsa-miR-181b and hsa-miR-143 were correlated with non-favorable risk and short overall survival. Regarding the miRNAs with upregulated expression in the non-favorable risk group, hsa-miR-188 and hsa-miR-501 were correlated with non-favorable risk and could predict poor survival. Through EV-derived miRNAs–mRNA network analysis using TCGA database, we identified 21 mRNAs that could be potential poor prognosis biomarkers.

Conclusions
Overall, our findings revealed that EV-derived miRNAs can serve as biomarkers for risk stratification and prognosis in AML. In addition, these EV-derived miRNA-based bioinformatic analyses could help efficiently identify mRNAs with biomarker potential, similar to the previous cell-based approach.
Physical activity, obesity and risk of atherosclerotic cardiovascular diseases among patients with hypertension and diabetes attending a teaching hospital in Edo State, Nigeria
Authors: Oseni Tijani Idris Ahmad , Ahmed Sulaiman Dazumi , Eromon Pauline Etuajie , Fuh Neba Francis , Omoregbe Isaac Newton 
Published: August 2024

Introduction
Preventing Atherosclerotic Cardiovascular Diseases (ASCVD) can best be achieved by promoting a healthy lifestyle through improvements in diet, physical activity, and avoidance of tobacco use and exposure to second-hand smoke. The study aimed to determine the association between physical activity as well as obesity and the risk of atherosclerotic cardiovascular diseases among patients with hypertension and diabetes attending Irrua Specialist Teaching Hospital (ISTH), Irrua, Nigeria.

Methodology
The research was a descriptive, cross-sectional study of 394 systematically selected consenting patients with hypertension and diabetes presenting to a teaching hospital in Irrua, Edo State, Nigeria. The Cardiovascular risk assessment was determined using the Framingham 10year Risk of General Cardiovascular Disease. Anthropometric assessment, blood pressure and blood glucose were determined. Data was collected with a semi-structured questionnaire and analysed with Stata version 16. Chi square and logistic regression was used to test for association and significance level was set at p = 0.05.

Results
The study included 394 participants with a mean age of 54±15.47years. Respondents were mostly females (55.3%), physically inactive (70.3%), overweight (42.4%) and had a high risk (41.8%) of developing CVD in 10 years using Framingham categorisation. There was a significant association between physical activity (P<0.01; OR 2.45; CI: 1.53–3.92), obesity (P<0.01; OR 2.52; CI: 1.64–3.86) and risk of developing CVD.

Conclusion
The study found a statistically significant relationship between physical inactivity, obesity, and the risk of atherosclerotic cardiovascular diseases. Increasing physical activity levels need to be a top priority at all levels of healthcare as well as the general population.
Dexamethasone inhibited angiotensin II and its receptors to reduce sepsis-induced lung and kidney injury in rats
Authors: Zhan Zhuqin , Lian Zhulan , Bai Haitao 
Published: August 2024

Objectives
To investigate the effect of dexamethasone (DXM) on acute lung and kidney injury with sepsis and its possible mechanism.

Methods
Control (NC), lipopolysaccharide (LPS) and lipopolysaccharide + dexamethasone (LPS+DXM) treated groups were established by random assignment of 72 Wistar rats. The NC rats were injected with physiological saline, while the LPS group was injected with LPS (5 mg/kg) and LPS+DXM group was injected with LPS(5 mg/kg) first and followed by DXM (1 mg/kg). Serum tumor necrosis factor-α (TNF-α) and serum macrophage inflammatory protein 1α (MIP-1α) were measured by ELISA. Lung wet/dry weight ratio, serum creatinine(SCR) and blood urea nitrogen(BUN) were determined at various time points. Hematoxylin Eosin staining (HE) for pathological changes in the lung and kidney. Radioimmunoassay was used to detect the levels of angiotensin II (Ang II) in plasma, lung and kidney tissues. Immunohistochemistry and western blot (WB) were used to detect angiotensin II receptor type 1 (AT1R) protein and angiotensin II receptor type 2 (AT2R) protein in lung and kidney tissues. The level of nitric oxide (NO) in serum, lung and kidney were detected using nitrate reductase method.

Results
Compared with control group, serum TNF-α, MIP-1α, SCR, BUN, lung W/D, Ang II level in plasma, lung and kidney, lung and kidney AT2R protein, NO level in serum, lung and kidney were significantly elevated(P<0.05) and pathological damage of lung and kidney tissues were showed in LPS group rats (P<0.05), whereas DXM down-regulated the above indexes and alleviate pathological damage of lung and kidney tissues. However, the expression of the lung and kidney AT1R protein was opposite to the above results.

Conclusions
Sepsis can cause acute lung and kidney injury and changes RAAS components in circulating, lung and renal. DXM can improve acute lung and kidney injury in septic rats, and the mechanism may be related to the down-regulation of inflammatory factors, AngII, AT2R, NO and up-regulation of AT1R expression by DXM.
Cine como dispositivo histórico-político en los casos de Cabra marcado para morrer y Chile, la memoria obstinada
Authors: Savernini Erika 
Published: August 2024

En los años 1960-1970, el cine latino-americano estuvo fuertemente marcado por la política a causa de las victorias de la Revolución Cubana y de Salvador Allende y de los regímenes dictatoriales instaurados entonces. Se produjo también un fortalecimiento de las cinematografías nacionales, que proponían estilos narrativos, estéticos y de producción propios. A partir de ese contexto, proponemos el análisis de dos casos particulares de películas rodadas en el momento de la eclosión del golpe, y que fueron retomadas cerca de 20 años después: Cabra marcado para morrer, del brasileño Eduardo Coutinho, y Chile, la memoria obstinada, de Patricio Guzmán. Esas películas registran lo que pasó con los personajes “comunes” que participaron en la producción anterior, promueven una resignificación de los acontecimientos, despiertan memorias individuales y construyen memorias histórico-colectivas.
Persisting Cutaneous Pancreatic Fistula in a Patient With Necrotizing Pancreatitis: A Novel Approach of Transfistulous Histoacryl Occlusion
Authors: Cardinal von Widdern Julian , Stangl Franz , Wohlgemuth Walter A. , Brill Richard , Kleeff Jörg , Rosendahl Jonas 
Published: August 2024

ABSTRACT
Necrotizing pancreatitis with superinfection of necrotic tissue is associated with a high rate of complications and mortality. The step-up approach is a well-established treatment strategy for necrotizing pancreatitis, emphasizing minimally invasive and endoscopic interventions before considering surgical options. Minimally invasive strategies often involve percutaneous drainage of collections, which carries the risk of persisting cutaneous pancreatic fistulas. Since there is currently no guidance for managing this scenario, we present a novel treatment approach that utilized tissue glue to occlude a persisting and clinically compromising percutaneous fistula. In addition, we summarize the current knowledge in the treatment of percutaneous pancreatic fistulas and provide a potential therapeutic algorithm for further evaluation.
Coexisting Organoaxial Gastric Volvulus and Sigmoid Volvulus With Complications
Authors: Sadikot Mariyam , Nicolle Gunter 
Published: August 2024

ABSTRACT
Very few cases of coexisting organoaxial gastric and sigmoid volvuli have been reported. In here we describe 1 such case. Our patient, a 92-year-old man, was treated with a flexible sigmoidoscopy with decompression for his sigmoid volvulus. For the gastric volvulus, the patient was initially treated with an upper endoscopic gastric decompression and subsequently treated with a laparoscopic anterior gastropexy. After the gastropexy, the patient developed bleeding and ischemia of the stomach, which is a rare complication due to the stomach's rich blood supply. This case report reiterates the need to consider rare complications in patients with such rare pathologies.
Necrotizing Pancreatitis After Bland Embolization of a Large Hepatic Hemangioma
Authors: Khan Ayesha , Hawes Julia , Zhang Julia , Khan Ahmed , Szauter Karen , Falamaki Maryamnaz , Kueht Michael L. , Cicalese Luca , Parupudi Sreeram 
Published: August 2024

ABSTRACT
Liver embolization is a common procedure for management of liver lesions. Embolization can be performed using only an embolic material or along with chemotherapy agents. Infrequent complications seen postliver embolization include pulmonary thromboembolism, hepatic infarct, liver abscess, liver failure, ischemic biliary strictures, and less frequently pancreatic damage (incidence of 1.7%). We describe a case of necrotizing pancreatitis after bland embolization of a large hepatic hemangioma. The exact mechanisms of acute pancreatitis after liver embolization are uncertain, although direct ischemic mechanisms, toxic effects of antineoplastic agents, and volume of embospheres used are believed to play a role.
Las fuentes en la formación disciplinar de los estudiantes del Primer Ciclo de las carreras de Historia. Dificultades que enfrentan los estudiantes en el trabajo con testimonios de la historia colonial americana
Authors: Vecari Silvina 
Published: August 2024

El artículo es parte de una investigación de tesis que abordó la comprensión de la especificidad del conocimiento histórico a través de la utilización de fuentes históricas en los procesos de enseñanza y de aprendizaje de la disciplina, con los objetivos de visibilizar las representaciones de estudiantes que obstaculizaban el abordaje de la conquista española de América, a la vez que reconocer las competencias que permitirían comprender e interpretar fuentes históricas. Describe una investigación-acción en la cátedra de Historia Americana I del Primer Ciclo de las carreras del Profesorado y Licenciatura en Historia, Facultad de Humanidades y Ciencias, Universidad Nacional del Litoral. La elección de una propuesta de investigación-acción facilitó el abordaje de situaciones áulicas experimentadas como problemáticas y requirió de la reflexión-en-la-acción sobre aspectos concernientes a las prácticas de enseñanza universitaria, como prácticas sociales que se configuran al considerar las particularidades, las heterogeneidades y las dificultades que poseen las/os sujetos que aprenden.
Beating Barriers to Formative Assessment in a Testing-Oriented Nation
Authors: Defianty Maya , Wilson Kate 
Published: August 2024

AbstractIndonesia has a been a testing-oriented country since its inception. Yet, over the past decade, assessment policies in Indonesia have gradually strengthened their emphasis on formative assessment. In general, Indonesian teachers’ understanding of formative assessment is still relatively modest; in fact, some teachers still consider formative assessment to be challenging, if not impossible. Nevertheless, others have embraced the concept and have managed to overcome the barriers of large classes, limited time, and the long-standing culture of high-stakes testing. This article aims to provide examples of good practice in formative assessment in ELT. We present the results of a multiple case study, involving eight ELT senior high school teachers representing various learning contexts in Indonesia. Drawing on data from interviews and classroom observations, the study revealed that these teachers recognized the barriers in implementing formative assessment deriving from limited time and large classes, yet they were able to overcome these barriers by using teaching modifications and technological tools as solutions to applying formative assessment. This study highlights the pivotal role of teachers’ assessment literacy to enhance and reap the benefits from formative assessment. AbstrakIndonesia telah menjadi negara yang berorientasi pada ujian sejak awal berdirinya. Tetapi, selama dekade terakhir, kebijakan penilaian di Indonesia secara bertahap semakin menekankan pada penilaian formatif. Secara umum, pemahaman guru-guru Indonesia tentang penilaian formatif masih relatif terbatas; faktanya, beberapa guru masih menganggap penilaian formatif sebagai hal yang menantang, bahkan tidak mungkin dilakukan. Meskipun demikian, beberapa guru telah menerima konsep ini dan berhasil mengatasi hambatan seperti kelas yang besar, waktu yang terbatas, dan budaya ujian berisiko tinggi yang telah berlangsung lama. Artikel ini bertujuan untuk memberikan contoh praktik baik dalam penilaian formatif dalam pengajaran Bahasa Inggris. Kami menyajikan hasil studi multi-kasus, yang melibatkan delapan guru Bahasa Inggris sekolah menengah atas yang mewakili berbagai konteks pembelajaran di Indonesia. Berdasarkan data dari wawancara dan observasi kelas, studi ini mengungkapkan bahwa para guru ini menyadari hambatan dalam menerapkan penilaian formatif yang berasal dari waktu yang terbatas dan kelas yang besar, namun mereka mampu mengatasi hambatan tersebut dengan menggunakan modifikasi pengajaran dan alat teknologi sebagai solusi untuk menerapkan penilaian formatif. Studi ini menyoroti peran penting literasi penilaian guru untuk meningkatkan dan memetik manfaat dari penilaian formatif. How to Cite: Defianty, D., Wilson, K. (2024). Beating Barriers to Formative Assessment in a Testing-Oriented Nation. TARBIYA: Journal of Education in Muslim Society, 11(1), 1-12. doi:10.15408/tjems.v11i1. 40391.
University Students' Awareness and Preparedness for Natural Disasters: A Study on Preventing Landslides, Earthquakes, and Volcanic Eruptions in Indonesia
Authors: Yoshinori Fujikawa , Tuswadi Tuswadi , Takehiro Hayashi , Tetsuo Isozaki , Subekti Niken 
Published: August 2024

AbstractThis study seeks to understand the disaster-prevention consciousness focused on landslide, earthquake, and volcanic eruption among 22 students pursuing a major in Geography in the Social Science Faculty, Semarang State University (UNNES), Indonesia. It analyzed the students’ consciousness through short comments toward questions “What can we do?”, which focused on preventing, defending, reducing, and mitigating the impacts of the three kinds of natural disasters. The average number of the description was 5.7, and the median was 5. More than half of the students mentioned points related to “before disaster and usual life,” “after disaster and restoration,” “hardware/structural,” and “software/non-structural.” All the answers described ideas with reasons. But only four students described ideas based on educational viewpoints, indicating students’ lack of scientific viewpoints in elaborating their ideas about disaster prevention. This finding calls for improving students’ consciousness regarding disaster prevention through education.AbstrakPenelitian ini bertujuan untuk memahami kesadaran pencegahan bencana yang difokuskan pada tanah longsor, gempa bumi, dan letusan gunung berapi di antara 22 mahasiswa yang mengambil jurusan Geografi di Fakultas Ilmu Sosial, Universitas Negeri Semarang (UNNES), Indonesia. Kesadaran mahasiswa dianalisis melalui komentar singkat terhadap pertanyaan "Apa yang bisa kita lakukan?", yang difokuskan pada pencegahan, pertahanan, pengurangan, dan mitigasi dampak dari tiga jenis bencana alam tersebut. Rata-rata jumlah deskripsi adalah 5,7, dan median adalah 5. Lebih dari setengah mahasiswa menyebutkan poin-poin yang terkait dengan "sebelum bencana dan kehidupan biasa," "setelah bencana dan pemulihan," "perangkat keras/struktural," dan "perangkat lunak/non-struktural." Semua jawaban menggambarkan ide-ide dengan alasan yang mendasarinya. Namun, hanya empat mahasiswa yang menguraikan ide-ide berdasarkan sudut pandang pendidikan, yang menunjukkan kurangnya sudut pandang ilmiah dalam mengelaborasi ide-ide mereka tentang pencegahan bencana. Temuan ini menunjukkan perlunya peningkatan kesadaran mahasiswa mengenai pencegahan bencana melalui pendidikan. How to Cite: Yoshinori, F, Tuswadi, Takehiro, H, Tetsuo, I., Subekti, N. (2024). "University Students' Awareness and Preparedness for Natural Disasters: A Study on Preventing Landslides, Earthquakes, and Volcanic Eruptions in Indonesia. TARBIYA: Journal of Education in Muslim Society, 11(1), 81-92. doi:10.15408/tjems.v11i1.40444.
Semantic shifts of ‘coming out’ and ‘come out of the closet’
Authors: Witalisz Alicja 
Published: August 2024

Juxtaposing lexicographic data with authentic corpora-excerpted contexts, this article investigates the semantic variance of coming out and come out of the closet in English and Polish. It discovers the linguistic sources of the LGBTQ+-related sense of coming out in English and focuses on the semantic shift from its sociolectal LGBTQ+-related usage towards nonsociolectal pragmatically marked uses, which result in extended collocability (e.g. Eng. coming out as an atheist; Pol. ateistyczny coming-out). The study contrasts English and Polish corpus data to see whether the nonsociolectal usage of Polish coming out can be argued to be contact-induced – that is, modelled on English. Language contact research shows that contact-induced innovations undergo semantic change through conscious and creative exploitation by recipient language speakers to realise their pragmatic needs. The cognitive-onomasiological theoretical framework, coupled with a usage-based methodology, allows investigation of how native and contact-induced phenomena are used by native and recipient language speakers.
The Role of Texture in the Expression of Musical Emotion: The Menuet from Bach’s Partita no. 4 in D Major, BWV 828
Authors: Hatten Robert 
Published: August 2024

Musical texture is a complex sign based on the functional interrelationship of all the “voices” in a given segment of music. In Bach’s era, textural categories were oppositionally conceived as primarily homophonic (block-chordal, or melody with chordal accompaniment) vs. polyphonic (linear-contrapuntal, often imitative). However, the Partitas, comprising the third and most compositionally advanced collection of his keyboard suites, exhibit an unusual variety of textures, both shifts among textures and imaginative blends of textural types. Since earlier suite dances are typically based on a single texture, Bach’s textural play suggests a deeper expressive motivation. I demonstrate how, in the Menuet from the Partita, Bach pioneers both textural contrast within phrases and an ongoing developing variation of texture to create a more highly nuanced expressive trajectory.