bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of infliximab in refractory FDG PET-positive sarcoidosis
Authors: Vorselaars Adriane D.M. , Crommelin Heleen A. , Deneer Vera H.M. , Meek Bob , Claessen Anke M.E. , Keijsers Ruth G.M. , van Moorsel Coline H.M. , Grutters Jan C. 
Published: May 2015

Inconclusive evidence for the efficacy of infliximab in sarcoidosis hinders the global use of this potentially beneficial drug. To study infliximab efficacy in a clinical setting, we performed a prospective open-label trial in patients refractory to conventional treatment.Patients (n=56) received eight infusions of 5 mg·kg-1infliximab. Pulmonary function, disease activity measured by18F-fluorodeoxyglucose (FDG) by positron emission tomography (PET) and quality of life were part of the clinical work-up. Infliximab levels were measured before every infusion.After 26 weeks of infliximab treatment, mean improvement in forced vital capacity (FVC) was 6.6% predicted (p=0.0007), whereas in the 6 months before start of treatment, lung function decreased. Maximum standardised uptake value (SUVmax) of pulmonary parenchyma on18F-FDG PET decreased by 3.93 (p<0.0001). High SUVmaxof pulmonary parenchyma at baseline predicted FVC improvement (R=0.62, p=0.0004). An overall beneficial response was seen in 79% of patients and a partial response was seen in 17% of patients. No correlation between infliximab trough level (mean 18.0 µg·mL-1) and initial response was found.In conclusion, infliximab causes significant improvement in FVC in refractory18F-FDG PET positive sarcoidosis. Especially in pulmonary disease, high18F-FDG PET SUVmaxvalues at treatment initiation predict clinically relevant lung function improvement. These results suggest that inclusion of18F-FDG PET is useful in therapeutic decision-making in complex sarcoidosis.
A note on some fundamental results in complete gauge spaces and application
Authors: Jleli Mohamed , Samet Bessem , Vetro Calogero , Vetro Francesca 
Published: April 2015

AbstractWe discuss the extension of some fundamental results in nonlinear analysis to the setting of gauge spaces. In particular, we establish Ekeland type and Caristi type results under suitable hypotheses for mappings and cyclic mappings. Our theorems generalize and complement some analogous results in the literature, also in the sense of ordered sets and oriented graphs. We apply our results to establishing the existence of solution to a second order nonlinear initial value problem.
Comparison of mechanical and manual bone marrow puncture needle for intraosseous access; a randomized simulation trial
Authors: Ohchi Fumihiro , Komasawa Nobuyasu , Mihara Ryosuke , Minami Toshiaki 
Published: May 2015

AbstractBackgroundDuring resuscitation, when it is difficult or impossible to establish peripheral venous access, intraosseous route (IO) is considered as an alternative to a central venous line. However, it is sometimes difficult for obtain IO access with conventional manual bone puncture needle. Recently, powered mechanical bone marrow needle was developed. We compared the performance of the manual and mechanical bone marrow puncture needle for adult, child and infant simulation.Methods22 anesthesiologists, who has never used bone marrow puncture needle, performed manual (Dickman™, Cook Medical) or mechanical (EZ-IO™, Teleflex) bone marrow puncture to simulated adult, child and infant tibia. Puncture success rate, insertion time, and subjective difficulty utilizing visual analogue scale was assessed.ResultsIn adult settings, with the manual bone marrow needle, only 3 of 22 participants could succeed in the IO route keep, while all participants did in the mechanical bone marrow puncture needle (P < 0.001). In child and infant settings, all trials were successful in both manual and mechanical bone marrow puncture needles (P = 1.00). In adult simulations, IO insertion took significantly longer with manual bone marrow puncture (54.8 ± 15.8 s) than without compressions (3.7 ± 2.1 s; P < 0.001). In child and infant simulations, the IO insertion time was significantly smaller in mechanical trials than in manual ones (child simulation; manual 9.3 ± 4.6 s, mechanical 2.2 ± 0.8 s, P < 0.001, infant simulation; manual 2.0 ± 1.1 s, mechanical 1.5 ± 0.8 s, P = 0.003).Although the VAS score was not significantly higher with manual trials than in mechanical trials among the three simulations (adult simulation, P < 0.001, child simulation, P < 0.001, infant simulation P = 0.006).ConclusionsWe conclude that in simulations managed by anesthesiologists who had no clinical experiences with bone marrow puncture, the mechanical bone puncture needle performed better than the manual one for emergency IO route access.
Modelling of aflatoxin G1 reduction by kefir grain using response surface methodology
Authors: Ansari Farzaneh , Khodaiyan Faramarz , Rezaei Karamatollah , Rahmani Anosheh 
Published: May 2015

Abstract
Aflatoxin G1 (AFG1) is one of the main toxic contaminants in pistachio nuts and causes potential health hazards. Hence, AFG1 reduction is one of the main concerns in food safety. Kefir-grains contain symbiotic association of microorganisms well known for their aflatoxin decontamination effects. In this study, a central composite design (CCD) using response surface methodology (RSM) was applied to develop a model in order to predict AFG1 reduction in pistachio nuts by kefir-grain (already heated at 70 and 110°C). The independent variables were: toxin concentration (X1: 5, 10, 15, 20 and 25 ng/g), kefir-grain level (X2: 5, 10, 20, 10 and 25%), contact time (X3: 0, 2, 4, 6 and 8 h), and incubation temperature (X4: 20, 30, 40, 50 and 60°C). There was a significant reduction in AFG1 (p < 0.05) when pre-heat-treated kefir-grain used. The variables including X1, X3 and the interactions between X2-X4 as well as X3-X4 have significant effects on AFG1 reduction. The model provided a good prediction of AFG1 reduction under the assay conditions. Optimization was used to enhance the efficiency of kefir-grain on AFG1 reduction. The optimum conditions for the highest AFG1 reduction (96.8%) were predicted by the model as follows: toxin concentration = 20 ng/g, kefir-grain level = 10%, contact time = 6 h, and incubation temperature = 30°C which validated practically in six replications.
Role of Vascular Function in Predicting Arteriovenous Fistula Outcomes: An Observational Pilot Study
Authors: MacRae Jennifer M , Ahmed Sofia , Hemmelgarn Brenda , Sun Yichun , Martin Billie-Jean , Roifman Idan , Anderson Todd 
Published: April 2015

Background: Many arteriovenous fistula (AVF) fail prior to use due to lack of maturation or thrombosis. Determining vascular function prior to surgery may be helpful to predict subsequent AVF success. This is a feasibility study to describe the vascular function in a cohort of chronic kidney disease (CKD) patients who are awaiting AVF creation. Methods: A prospective cohort of 28 CKD patients expected to progress to HD underwent arterial stiffness (pulse wave velocity, PWV) and endothelial function testing (flow mediated dilation FMD, and peripheral arterial tonometry, PAT) one week prior to AVF creation. AVF success was defined as maintaining patency and achieving maturation. Post operative fistula assessment at 8 weeks evaluated maturation (clinical assessment of adequate fistula flowand ultrasound diameter ≥ 0.5 cm). Results: The median age 72 years (62 – 78), 75% males, eGFR 15 ml/min/1.73 m2 (12 – 18). 20 (71%) patients had successful AVF surgery with a mature AVF at 8 weeks. Patients with AVF success had higher mean PAT values 1.87 ± 0.52 than those with failed AVF 1.41 ± 0.24 p = 0.03. Conclusions: Microvascular endothelial function as measured using PAT may be useful as a predictor of AVF maturation and function. This simple non invasive marker of vascular function may be a useful tool to predict AVF outcomes.
Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis
Authors: Iwama Shintaro , Sugimura Yoshihisa , Kiyota Atsushi , Kato Takuya , Enomoto Atsushi , Suzuki Haruyuki , Iwata Naoko , Takeuchi Seiji , Nakashima Kohtaro , Takagi Hiroshi , Izumida Hisakazu , Ochiai Hiroshi , Fujisawa Haruki , Suga Hidetaka , Arima Hiroshi , Shimoyama Yoshie , Takahashi Masahide , Nishioka Hiroshi , Ishikawa San-e , Shimatsu Akira , Caturegli Patrizio , Oiso Yutaka 
Published: April 2015

Context:Central diabetes insipidus (CDI) can be caused by several diseases, but in about half of the patients the etiological diagnosis remains unknown. Lymphocytic infundibulo-neurohypophysitis (LINH) is an increasingly recognized entity among cases of idiopathic CDI; however, the differential diagnosis from other pituitary diseases including tumors can be difficult because of similar clinical and radiological manifestations. The definite diagnosis of LINH requires invasive pituitary biopsy.Objective:The study was designed to identify the autoantigen(s) in LINH and thus develop a diagnostic test based on serum autoantibodies.Design:Rat posterior pituitary lysate was immunoprecipitated with IgGs purified from the sera of patients with LINH or control subjects. The immunoprecipitates were subjected to liquid chromatography-tandem mass spectrometry to screen for pituitary autoantigens of LINH. Subsequently, we made recombinant proteins of candidate autoantigens and analyzed autoantibodies in serum by Western blotting.Results:Rabphilin-3A proved to be the most diagnostically useful autoantigen. Anti-rabphilin-3A antibodies were detected in 22 of the 29 (76%) patients (including 4 of the 4 biopsy-proven samples) with LINH and 2 of 18 (11.1%) patients with biopsy-proven lymphocytic adeno-hypophysitis. In contrast, these antibodies were absent in patients with biopsy-proven sellar/suprasellar masses without lymphocytic hypophysitis (n = 34), including 18 patients with CDI. Rabphilin-3A was expressed in posterior pituitary and hypothalamic vasopressin neurons but not anterior pituitary.Conclusions:These results suggest that rabphilin-3A is a major autoantigen in LINH. Autoantibodies to rabphilin-3A may serve as a biomarker for the diagnosis of LINH and be useful for the differential diagnosis in patients with CDI.
“Disengaging from the Muslim Spirit”
Authors: Drucker Peter 
Published: May 2015

Abstract
The project of the French Alliance Israélite Universelle (AIU) in Morocco in the late nineteenth and early twentieth centuries—to win social and political equality for Jews through European enlightenment—was intertwined with the French imperial project. Moroccan Jewish women were assigned, as mothers and wives, a special role in the AIU’s efforts: to help Jewish boys and men pursue commercial or professional careers in French-dominated society. The AIU schools set out to win Moroccan Jews away from despised Muslim gender and sexual norms by Europeanizing Jews’ marriage patterns and family forms, combating prostitution, eliminating women’s traditional head coverings, and reining in what the AIU saw as men’s promiscuity and homosexual tendencies. Ultimately, the AIU helped further estrange Moroccan Jews from Muslims but failed to secure Moroccan Jews’ smooth integration into French secular culture. Moroccan Jews in Israel today, faced with persistent discrimination, largely cling to religiously based, conservative gender norms.
Impact of Alkyl Side Chains on Thin-film Transistor Performances in Phenanthrodithiophene–Isoindigo Copolymers
Authors: Nishinaga Shuhei , Mori Hiroki , Nishihara Yasushi 
Published: April 2015

Abstract
Organic field-effect transistor (OFET) characteristics of phenanthrodithiophene (PDT)–isoindigo (IID) copolymers with different alkyl chains (12OD and BOBO) as an active layer, and their structure–property relationships are described. The fabricated 12OD-based OFET device exhibited hole mobility of 0.16 cm2 V−1 s−1. Grazing-incidence wide-angle X-ray scattering (GIWAXS) analysis revealed that 12OD formed highly ordered edge-on structure, whereas the BOBO film showed amorphous-like structure with no obvious π-stacking crystallites. This may be attributed to a large steric hindrance of branched side chains in the BOBO polymer, which suppresses effective π–π overlaps between the adjacent polymer backbones.
Détournement as optic: Debord, derisory documents and the aerial view
Authors: Stob Jennifer 
Published: April 2015

Abstract
For Situationist, theorist and film-maker Guy Debord, the aerial view reproduced the falsely objective world-view he called ‘the spectacle’. To counter its myth of an infinitely expandable, omniscient perspective, Debord focused on reducing views from above to ‘derisory documents’ of the social and the environmental through détournement in the two films he made while the Situationist International was in existence. The films engage critically with aerial photography as a hegemonic mode of indexical media, with the aerial view’s application as information image and ornament, and with the formal phenomenon of ciné-mapping. This analysis suggests that the détournement Debord performs in and across these films can be best conceptualized as a critical optic that constitutes a practice of seeing, a mode of reception and a call to action in the social space beyond its aesthetic employ. As such, the optic of détournement is the contestational counterpart to the optic of the aerial view. This remains the case despite the contemporary complexity of photographic views from above and their increased abstraction of social agents and spaces. An alternative to the testimonial function of embodied photographic views, détournement as optic represents an indexical civil contract founded upon representational inadequacy.
Event Driven Control of Vibratory Conveyors Operating on the Frahm's Eliminator Basis
Authors: Klemiato M. , Czubak P. 
Published: April 2015

Abstract
The new, original control method of the vibratory conveyor operating on the Frahm's dynamic eliminator basis, is presented in the paper. The proposed method is based on the application of the control of the feed-forward controler, together with the events detection based on the generalised likelihood ratio (GLR) algorithm. Such approach leads to the controller intervention only when it is justified by the current process situation, (e.g. in case of an essential change of the feed mass) to enable the stable machine operations and to limit transient states. The results are presented in a form of numerical simulations.
An Evaluation of the use of Laser-Vibration Melting to Increase the Surface Roughness of Metal Objects
Authors: Grabas B. 
Published: April 2015

Abstract
This paper presents preliminary, experimental results of a new, hybrid method of increasing the surface roughness of metal objects. In this new approach, metal objects are melted with a mobile laser beam while they are being rotated. A vibration generator provides circular vibrations with an amplitude of 3 mm, and the vibration plane is perpendicular to the moving laser beam. The melting tests were performed using flat carbon steel samples at a predetermined frequency of circular vibrations. The effects of laser power and laser beam scanning velocity on the melted shapes were studied. All laser melting procedures were performed at a vibration frequency of 105 Hz. The melted samples were subjected to microscopic evaluation and the Ra parameter, which characterises mean roughness, was measured using a profilometer. Melting metal samples with physically smooth surfaces (Ra = 0.21 µm) resulted in surface structures of varied roughness values, with Ra ranging from 5 µm to approximately 58 µm. The studies were undertaken to employ this technology for the purpose of passive heat exchange intensification of heating surfaces in practical applications.
Comparison of Four Models of Radiative Heat Transfer Between Flat Surface to Evaluate the Temperature Field Based on Example of the Continuous Casting Mould
Authors: Rywotycki M. , Malinowski Z. , Miłkowska-Piszczek K. , Gołdasz A. , Hadała B. 
Published: April 2015

AbstractThe paper presents the results of research concerning the influence of radiative heat transfer on the strand and mould interface. The four models for determining the heat transfer boundary conditions within the primary cooling zone for the continuous casting process of steel have been presented. A cast slab - with dimensions of 1280×220 mm - has been analysed. Models describing the heat transfer by radiation have been specified and applied in the numerical calculations. The problem has been solved by applying the finite element method and the self-developed software. The simulation results, along with their analysis, have been presented. The developed models have been verified based on the data obtained from the measurements at the industrial facility.
A Comparison of Models Describing Heat Transfer in the Primary Cooling Zone of a Continuous Casting Machine
Authors: Miłkowska-Piszczek K. , Rywotycki M. , Falkus J. , Konopka K. 
Published: April 2015

Abstract
This paper presents the findings of research conducted concerning the determination of thermal boundary conditions for the steel continuous casting process within the primary cooling zone. A cast slab - with dimensions of 1100 mm×220 mm - was analysed, and models described in references were compared with the authors’ model. The presented models were verified on the basis of an industrial database. The research problem was solved with the finite element method using the ProCAST software package.
Analysis of Al-Cu Bimetallic Bars Properties After Explosive Welding and Rolling in Modified Passes
Authors: Mróz S. , Szota P. , Stefanik A. , Wąsek S. , Stradomski G. 
Published: April 2015

Abstract
The paper presents the results of the experimental tests of Al-Cu bimetallic bars rolling process in multi-radial modified passes. The bimetallic bars consist of aluminium core, grade 1050A and copper outer layer, grade M1E. The stocks were round bars with diameter 22 mm with a copper layer share of 15 and 30%. As a result of rolling in four passes, bars of a diameter of about 16.0 mm were obtained. A bimetallic stock was manufactured using an explosive welding method. The use of the designed arrangement of multi-radial modified stretching passes resulted in obtaining Al-Cu bimetallic bars with the required lateral dimensions, an uniform distribution of the cladding layer over the bar perimeter and high quality of shear strength between individual layers.
Corrosion Resistance of The Bearing Steel 67SiMnCr6-6-4 with Nanobainitic Structure
Authors: Skołek E. , Dudzińska K. , Kamiński J. , Świątnicki W.A. 
Published: April 2015

AbstractThe paper describes a comparative study of the corrosion resistance of bearing steel 67SiMnCr6-6-4 after two kinds of nanostructuring treatments and two kinds of conventional quenching and tempering treatments. The nanostructuring treatment consisted of austempering with an isothermal quenching at 240°C and 300°C. The conventional heat treatment consisted on quenching and tempering at 350°C for 1 h and quenching and tempering at 550°C for 1 h. Time and temperature of tempering was chosen so that the hardness of both samples (nanostructured as well as quenched and tempered) was similar. The microstructure of steel after each heat treatment was described with the use of transmission electron microscopy (TEM). It was shown, that the austempering conducted at 240°C produced homogenous nanobainitic structure consisting of carbide-free bainite plates with nanometric thickness separated by the layers of retained austenite. The austempering at 300°C produced a sub-micrometric carbide-free bainite with retained austenite in form of layers and small blocks. The conventional heat treatments led to a tempered martensite microstructure. The corrosion resistance study was carried out in Na2SO4acidic and neutral environment using potentiodynamic and electrochemical impedance spectroscopy (EIS) methods. The corrosion resistance of nanostructured steel samples were compared to the steel samples with tempered martensite. The obtained results indicate, that the corrosion resistance of bearing steel with nanobainitic structure is similar to steel with tempered martensite in both acidic and neutral environment. This means that the high density of intercrystalline boundaries in nanobinite does not deteriorate the corrosion properties of the bearing steel.
An optimal mass transport approach for limits of eigenvalue problems for the fractional p-Laplacian
Authors: Del Pezzo Leandro , Rossi Julio , Saintier Nicolas , Salort Ariel 
Published: April 2015

AbstractWe find an interpretation using optimal mass transport theory for eigenvalue problems obtained as limits of the eigenvalue problems for the fractional p-Laplacian operators as p → +∞. We deal both with Dirichlet and Neumann boundary conditions.
Development of Smart Nanocontainers With A Zinc Phosphate Core and A pH-Responsive Shell for Controlled Release of Immidazole
Authors: Jadhav Ananda Jaysing , Karekar Sammit Ekanath , Pinjari Dipak Vitthal , Datar Yogesh Gajanan , Bhanvase Bharat Apparao , Sonawane Shirish Hari , Pandit Aniruddha Bhalchandra 
Published: April 2015

AbstractA simple and flexible method has been developed to fabricate reversibly switchable nanocontainers (by layer by layer assembly) using zinc phosphate (ZP) nanoparticles as a core material and subsequent deposition of oppositely charged species of polyelectrolyte (polyaniline and polyacrylic acid) and organic corrosion inhibitor (immidazole). Immidazole was entrapped between polyaniline (PANI) and polyacrylic acid (PAA). The PAA nanovalve can control the access of immidazole molecules to and from the nanocontainers. The average particle size of the synthesized nanocontainer was found to be in the range of 250–500 nm. X-ray diffraction (XRD), particle size analysis (PSA), zeta potential, and fourier transform infrared spectroscopy (FTIR) analysis confirms the successful formation of the layered structure of nanocontainers. UV-vis spectroscopy was used to analyze the release rate of immidazole in media of different pH as a function of time. This core-shell nanostructure can have potential applications in corrosion inhibition paint formulation.
CO2 Sorption-Enhanced Processes by Hydrotalcite-Like Compounds at Different Temperature Levels
Authors: Gallucci K. , Micheli F. , Barisano D. , Villone A. , Foscolo P.U. , Rossi L. 
Published: April 2015

Abstract
The aim of this work is to identify solid sorbents for CO2 capture for coal and biomass syngas conditioning and cleaning by means of a sorption-enhanced reaction process. Hydrotalcite-like compounds (HTlcs) were synthesized with and without K2CO3 impregnation. Samples were characterized by scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET) and Barrett–Joyner–Halenda (BJH) porosimetry after synthesis and after capture tests, respectively. Sorption and desorption tests were performed in a fluidized bed reactor, under cyclic conditions, at two different temperature levels: 350/450°C and 600/700°C. At low temperature only the Mg–Al HTlcs K promoted samples showed stability and sorption capacity comparable with literature values. On the other hand, results at high temperature indicate that the mixed Mg-Ca-Al HTlcs samples exhibit the best behavior with the highest sorption capacity (1.7 mmolCO2/g) almost stable over 5 sorption/regeneration cycles; furthermore, addition of steam allowed increasing their reactivity by 70% compared to the dry value. This type of sorbent could be a promising candidate to prepare a bifunctional sorbent–catalyst for sorption-enhanced processes, taking place directly in the fluidized bed gasifier, or downstream the reactor for adjustment of gas composition before further conversion in gaseous energy carriers.