bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the importance of CI/CD practices for database applications
Authors: Fluri Jasmin , Fornari Fabrizio , Pustulka Ela 
Published: August 2024

SummaryContinuous integration and continuous delivery (CI/CD) automate software integration and reduce repetitive engineering work. While the use of CI/CD presents efficiency gains, in database application development, this potential has not been fully exploited. We explore the state of the art in this area, with a focus on current practices, common software tools, challenges, and preconditions that apply to database applications. The work is grounded in a synoptic literature review and contributes a novel generic CI/CD pipeline for database system application development. Our generic pipeline was tailored to three industrial development use cases in which we measured the benefits of integration and deployment automation. The measurements demonstrate clearly that introducing CI/CD had significant benefits. It reduced the number of failed deployments, improved their stability, and increased the number of deployments. Interviews with the developers before and after the implementation of the CI/CD show that the pipeline brings clear benefits to the development team (i.e., a reduced cognitive load). These findings put current database release practices driven by business expectations, such as fixed release windows, in question.
Membranen im Wind von allen Seiten
Authors: Lienhard Julian , Bidier Sami , Michalski Alexander 
Published: August 2024

AbstractWindlasten auf Membrantragwerken sind nicht normativ geregelt. Die Formenvielfalt der meist offenen und somit beidseitig umströmten Flächen lässt sich nicht mit geometrischen Variablen tabellarisch erfassen, wie es bspw. im Eurocode EN 1991‐1‐4 für typische Gebäudeformen üblich ist. Die daher empfohlenen individuellen Windkanaltests sind jedoch nur für größere Projekte mit entsprechendem Budget und Planungszeiträumen darstellbar. So haben sich in der Literatur einige Empfehlungen für typische Membrandächer gesammelt und gleichzeitig hat sich die computerbasierte Windsimulation so weit entwickelt, dass sie inzwischen auch in den marktüblichen FEM‐Software‐Paketen angeboten wird. Wie es um die Genauigkeit der verschiedenen Ansätze und deren Vergleichbarkeit steht, soll anhand von Fallbeispielen erläutert werden. Der vorliegende Beitrag zeigt die Analyse von Normansätzen, Literaturwerten, Windkanaltests und computergestützten Verfahren mit einem Vergleich von Berechnungsergebnissen und gibt einen Einblick in die Entwicklung der Lastansätze im Membranbau.
Genome‐wide association study of carotenoids in maize kernel
Authors: Chen Weiwei , Zhang Xiangbo , Lu Chuanli , Chang Hailong , Chachar Zaid , Fan Lina , An Yuxing , Li Xuhui , Qi Yongwen 
Published: August 2024

AbstractMaize (Zea mays L.) kernel pigments mainly consist of natural pigments, such as carotenoids, which are the second largest class of natural pigments and have some functions that are healthful to humans. It is essential to analyze the genetic mechanism of carotenoid biosynthesis and establish the molecular marker technology system for the breeding of maize germplasm. In this study, we utilized an association panel comprising 244 maize inbred lines and about three million single nucleotide polymorphism (SNP) markers for the genome‐wide association study (GWAS) and to preliminarily analyze the genetic bases of maize kernel carotenoids. The main carotenoids in maize kernels were found to be lutein, zeaxanthin, β‐cryptoxanthin, and β‐carotene, as determined by high‐performance liquid chromatography. The GWAS revealed that a total of 826 quantitative trait loci (QTLs) were significantly associated with carotenoids contents, 35 QTLs were simultaneously mapped by at least two traits, and 87 candidate genes were located in the meta‐QTL regions. Eight stable QTLs that were identified by more traits in the two environments were selected for the superior allelic variation analysis for germplasem selection. The results of this study can provide a theoretical basis for screening genes that guide kernel carotenoids selection breeding.
Rural‐Urban mild cognitive impairment comparison in West Michigan through EHR
Authors: Zhang Xiaodan , Witteveen‐Lane Martin , Skovira Christine , Dave Aakash A. , Jones Jeffrey S. , McNeely Erin R. , Lawrence Michael R. , Morgan David G. , Chesla Dave , Chen Bin 
Published: August 2024

AbstractINTRODUCTIONMild cognitive impairment (MCI) is a significant public health concern and a potential precursor to Alzheimer's disease (AD). This study leverages electronic health record (EHR) data to explore rural‐urban differences in MCI incidence, risk factors, and healthcare navigation in West Michigan.METHODSAnalysis was conducted on 1,528,464 patients from Corewell Health West, using face‐to‐face encounters between 1/1/2015 and 7/31/2022. MCI cases were identified using International Classification of Diseases (ICD) codes, focusing on patients aged 45+ without prior MCI, dementia, or AD diagnoses. Incidence rates, cumulative incidences, primary care physicians (PCPs), and neuropsychology referral outcomes were examined across rural and urban areas. Risk factors were evaluated through univariate and multivariate Cox regression analyses. The geographic distribution of patient counts, hospital locations, and neurology department referrals were examined.RESULTSAmong 423,592 patients, a higher MCI incidence rate was observed in urban settings compared to rural settings (3.83 vs. 3.22 per 1,000 person‐years). However, sensitivity analysis revealed higher incidence rates in rural areas when including patients who progressed directly to dementia. Urban patients demonstrated higher rates of referrals to and completion of neurological services. While the risk factors for MCI were largely similar across urban and rural populations, urban‐specific factors for incident MCI are hearing loss, inflammatory bowel disease, obstructive sleep apnea, insomnia, being African American, and being underweight. Common risk factors include diabetes, intracranial injury, cerebrovascular disease, coronary artery disease, stroke, Parkinson's disease, epilepsy, chronic obstructive pulmonary disease, depression, and increased age. Lower risk was associated with being female, having a higher body mass index, and having a higher diastolic blood pressure.DISCUSSIONThis study highlights rural‐urban differences in MCI incidence and access to care, suggesting potential underdiagnosis in rural areas likely due to reduced access to specialists. Future research should explore socioeconomic, environmental, and lifestyle determinants of MCI to refine prevention and management strategies across geographic settings.Highlights
Leveraged EHRs to explore rural‐urban differences in MCI in West Michigan.
Revealed a significant underdiagnosis of MCI, especially in rural areas.
Observed lower rates of neurological referrals and completions for rural patients.
Identified risk factors specific to rural and urban populations.
Development of scalable protocol for pretreatment and extraction of lipids from wet Scenedesmus acuminatus TH04 biomass
Authors: Van Do Thi Cam , Dung Nguyen Thi Phuong , Phuong Nguyen Thi Thu , Thuan Tran Dang 
Published: August 2024

AbstractLipid extraction is a crucial step to obtain algal oils for substantial conversion to biofuels (biodiesel and bio‐jet fuels) and lipids‐based bioproducts from microalgal biomass. Conventional extraction technologies based on dry biomass has been well developed, however, these technologies are not economically viable. In this work, wet biomass of Scenedesmus acuminatus TH04 strain were used to optimize lipid yield via different pretreatment strategies followed by lipid extraction using biphasic solvents. It was found that the optimal pretreatment conditions were pretreatment temperature of 90 °C, time of 30 min, acid concentration of 1.5% H2SO4, and liquid‐to‐solid loading of 25% (w/w). Solvent used for lipid extraction and recovery was n‐hexane/ethanol (3/1, v/v) under stirring rate of 200 rpm, temperature of 25 °C for 2 h at 4 L solvent per 1 kg fresh biomass, achieving lipid yield of over 95%. Crude lipid was successfully purified with Sol® D‐60 or Magnesol® XL to obtain purified lipid of 92.4% purity. The developed protocol of thermal treatment, extraction, and purification was validated to work well with up to 20 kg wet algal biomass scale. Our first trial demonstrated that the protocol is efficient and scalable for lipids extraction from wet algal biomass, which is more sustainable in comparison to several technologies such as ultrasonic‐, microwave‐, ionic lipids‐assisted treatment and extraction.
Determining orbital volumes of sheep, goats and gazelles via computed tomography
Authors: Koçyiğit Ali , Demircioğlu İsmail , Demiraslan Yasin , Karaavci Funda Aksünger , Dayan Mustafa Orhun 
Published: August 2024

AbstractBackgroundOrbital volume refers to the sum of bulbus oculi volume and orbital cavity volume. Scientists use orbital volume as a guide to diagnose, treat and prognose various eye diseases such as thyroid eye disease and enophthalmos.ObjectiveThis study aims to examine the orbital volumes of sheep, goats and gazelles to demonstrate homotypic variations and interspecific differences between them.MethodsCrania of six male tuj sheep, five male hair goats and five male gazelle were used in this study. The crania were scanned using a 64‐detector multi‐detector computed tomography with a slice thickness of 0.625 mm at 80 kV, 200 MA and 639 mGy. The cross‐sectional images were stored in DICOM format and then transferred to MIMICS 20.1 software. Afterwards, models were made by establishing the orbital borders on the cross‐sections. Volume values were calculated based on the models.Results and ConclusionNo homotypic variation was found between the right and left volumes within the species (p > 0.05). A statistically significant difference was observed in terms of interspecific right and left orbital volumes between sheep and gazelles (p < 0.05). It was concluded that the orbital parameters of the sheep, goats and gazelles in the same family help reveal their differences in the visual anatomy of these species and provide reference data for clinical diagnosis, treatment and the prognosis follow‐up of ocular diseases in animals.
Comparative analysis of breeding patterns and reproductive efficiency of mares in subtropical conditions of Pakistan
Authors: Mahmood Khalid , Hassan Mubbashar , Channa Aijaz Ali , Ghafoor Aamir , Riaz Amjad 
Published: August 2024

AbstractBackground and AimThe present study aimed to evaluate and compare the overall and breed‐specific seasonal breeding patterns, fertility rates, cyclicity, and follicular dynamics of Arab, Thoroughbred, and Percheron mares under the subtropical conditions of Pakistan.Materials and MethodsA retrospective analysis of climatic data and breeding records of eleven breeding studs spanning four years (2020–2023) was made to find out the overall seasonality in the breeding pattern of mares. Fifty mares of each breed (n = 150 in total) were scanned by ultrasonography for a calendar year to find the cyclicity pattern and follicular dynamics (follicular growth rate, size of ovulatory follicle, and days from estrus till ovulation).Results and DiscussionThe statistical analysis of breeding records demonstrated a clear pattern of seasonal breeding (p< 0.05). The highest monthly foalings were noted in March (247 ± 45.37), and overall breeding activities peaked in Spring season (p< 0.05). Breed‐specific results of Arab, Thoroughbred, and Percheron mares revealed that Arab mares maintained stable breeding activity throughout the year, with the highest activity in spring and peak conception rate in winter (56.25% ± 32.78; p > 0.05). Thoroughbred mares experienced significant seasonal declines from spring to winter with a peak conception rate in winter (63.89% ± 27.37, p > 0.05). Percherons showed the most pronounced seasonal effects, especially with a high fall conception rate (73.04% ± 19.61) and a sharp decrease in winter breeding metrics (p< 0.05). Furthermore, Thoroughbred and Percheron mares displayed the most pronounced seasonal effects on the percentage of cyclic mares 77.3% and 56% in winters (p< 0.05). Moreover, the follicular dynamics of the three breeds also exhibited significant differences (p< 0.05).ConclusionThe current study concludes that seasonal and breed‐specific variability exists among the reproductive parameters of Arab, Thoroughbred, and Percheron mares in subtropics, necessitating breed‐specific reproductive management measures to maximize mare breeding efficiency.
A critical analysis of surgical outcomes indicators in hepato‐pancreato‐biliary surgery: From crude mortality to composite outcomes
Authors: Di Martino Marcello , Nicolazzi Marco , Baroffio Paolo , Polidoro Michela Anna , Colombo Mainini Cecilia , Pocorobba Amanda , Bottini Eleonora , Donadon Matteo 
Published: August 2024

AbstractBackgroundIndicators of surgical outcomes are designed to objectively evaluate surgical performance, enabling comparisons among surgeons and institutions. In recent years, there has been a surge in complex indicators of perioperative short‐term and long‐term outcomes. The aim of this narrative review is to provide an overview and a critical analysis of surgical outcomes indicators, with a special emphasis on hepato‐pancreato‐biliary (HPB) surgery.MethodsA narrative review of outcome measures was conducted using a combined text and MeSH search strategy to identify relevant articles focused on perioperative outcomes, specifically within HPB surgery.ResultsThe literature search yielded 624 records, and 94 studies were included in the analysis. Included papers were classified depending on whether they assessed intraoperative or postoperative specific or composite outcomes, and whether they assessed purely clinical or combined clinical and socio‐economic indicators. Specific indicators included in composite outcomes were categorized into three main domains: intraoperative metrics, postoperative outcomes, and oncological outcomes. While postoperative mortality, complications, hospital stay and readmission were the indicators most frequently included in composite outcomes, oncological outcomes were rarely considered.ConclusionsThe evolution of surgical outcomes has shifted from the simplistic assessment of crude mortality rates to complex composite outcomes. Whether the recent explosion of publications on these topics has a clinical impact in real life is questionable. Outcomes from the patient perspective, integrating social and financial indicators, are not yet integrated into most of these composite analytical tools but should not be underestimated.
Pseudoscalar Higgs plus jet production at Next-to-Next-to-Leading Order in QCD
Authors: Kim Youngjin , Williams Ciaran 
Published: August 2024

Abstract
We present a calculation of pseudoscalar Higgs production in association with a jet at Next-to-Next-to Leading Order (NNLO) accuracy in QCD. We work in an effective field theory in which mt → ∞ resulting in effective operators which couple the pseudoscalar to gluons and (massless) quarks. We have calculated all of the relevant amplitudes for the two-loop, one-loop and tree-level contributions. As a cross-check of our calculation we have re-calculated all of the scalar Higgs plus parton amplitudes and perform a detailed comparison to the literature. In order to regulate the infra-red singularities present at this order we employ the N-jettiness slicing method. In addition to a detailed validation of our calculation at this order we investigate LHC phenomenology for a selection of pseudoscalar Higgs masses. Our results are implemented into the parton-level Monte Carlo code MCFM.
Uncertainty quantification for μ → e conversion in nuclei: charge distributions
Authors: Noël Frederic , Hoferichter Martin 
Published: August 2024

Abstract
Predicting the rate for μ → e conversion in nuclei for a given set of effective operators mediating the violation of lepton flavor symmetry crucially depends on hadronic and nuclear matrix elements. In particular, the uncertainties inherent in this non-perturbative input limit the discriminating power that can be achieved among operators by studying different target isotopes. In order to quantify the associated uncertainties, as a first step, we go back to nuclear charge densities and propagate the uncertainties from electron scattering data for a range of isotopes relevant for μ → e conversion in nuclei, including 40,48Ca, 48,50Ti, and 27Al. We provide as central results Fourier-Bessel expansions of the corresponding charge distributions with complete covariance matrices, accounting for Coulomb-distortion effects in a self-consistent manner throughout the calculation. As an application, we evaluate the overlap integrals for μ → e conversion mediated by dipole operators. In combination with modern ab-initio methods, our results will allow for the evaluation of general μ → e conversion rates with quantified uncertainties.
Whole brain radiation therapy for patients with brain metastases: survival outcomes and prognostic factors in a contemporary institutional series
Authors: Estermann Anna , Schneider Chiara , Zimmermann Frank , Papachristofilou Alexandros , Finazzi Tobias 
Published: August 2024

Abstract
Purpose
To study survival outcomes and prognostic factors in patients undergoing whole brain radiation therapy (WBRT) for brain metastases in the contemporary setting.

Methods
Patients undergoing WBRT from 2013–2021 were retrospectively included in an ethics-approved institutional database. Patient and treatment characteristics were assessed, including patient age, primary tumor histology, Karnofsky Performance Status (KPS), extracranial disease, as well as WBRT dose. Overall survival (OS) was calculated from onset of WBRT using the Kaplan-Meier method.

Results
A total of 328 patients (median age 63 years) were included. Most patients (52%) had ≥ 10 brain metastases, and 17% had leptomeningeal disease. WBRT was delivered with 10 × 3 Gy (64%), 5 × 4 Gy (25%), or other regimens (11%).
Median follow-up was 4.4 months (range, 0.1–154.3), and median OS was 4.7 months (95%CI, 3.8–6.0). OS differed between histologies (p = 0.01), with the longest survival seen in breast cancer (median 7.7 months). Patients with KPS of 90–100 survived for a median of 8.3 months, compared to 4.1 months with KPS 70–80, and 1.7 months with KPS < 70 (p < 0.01).
Multivariate analyses revealed that KPS had the largest impact on survival. Patients who received a WBRT dose of ≥ 30 Gy also had a reduced risk of death (HR 0.45; p < 0.001). Survival differed between subgroups reclassified according to the Rades scoring system (p < 0.01).

Conclusion
Survival outcomes of patients undergoing WBRT in the contemporary era appear comparable to historical cohorts, although individual patient factors need to be considered. Patients with otherwise favorable prognostic factors may benefit from longer-course WBRT.
Striking the balance: ethical challenges and social implications of AI-induced power shifts in healthcare organizations
Authors: Hähnel Martin , Pfeiffer Sabine , Graßmann Stephan 
Published: August 2024

AbstractThe emergence of new digital technologies in modern work organizations is also changing the way employees and employers communicate, design work processes and responsibilities, and delegate. This paper takes an interdisciplinary—namely sociological and philosophical—perspective on the use of AI in healthcare work organizations. Using this example, structural power relations in modern work organizations are first examined from a sociological perspective, and it is shown how these structural power relations, decision-making processes, and areas of responsibility shift when AI is used. In the subsequent ethical part, opportunities for a fairer organization of work, but also dangers due to possibly changed power relations are elaborated and evaluated by presenting a realistic scenario from everyday clinical practice. After combining a proceduralist account of organizational ethics with a virtue-ethical approach, it is argued that certain organizational and character dispositions are necessary for employers and employees to meet the challenge of changing structural power relations in the future. With the same goal, a summative sociological perspective discusses challenges to workplace co-determination.
Feasibility, timing and outcome of leadless cardiac pacemaker implantation in patients undergoing cardiac implantable electronic device extraction
Authors: Kiblboeck Daniel , Blessberger Hermann , Ebner Jakob , Boetscher Jakob , Maier Julian , Reiter Christian , Kellermair Joerg , Steinwender Clemens , Saleh Karim 
Published: August 2024

Abstract
Background
Patients requiring extraction of infected or dysfunctional cardiac implantable electronic devices (CIED) have high morbidity and mortality. The Micra™ leadless cardiac pacemaker (LCP) may be beneficial for patients requiring permanent pacemaker therapy after CIED extraction.

Methods
This study aimed to assess the feasibility, timing and outcomes of LCP implantation in patients who underwent CIED extraction due to infection or dysfunction. The local Micra™ LCP registry was reviewed for LCP implantations and CIED extractions.

Results
Micra™ LCP implantation was scheduled for 48 consecutive patients (21 women, 44%) undergoing CIED extraction for infection (n = 38, 79%) or dysfunction (n = 10, 21%), and feasible in 47 (98%). Complete CIED removal was feasible in 44 patients (92%) and in 37/38 patients with infected CIED (97%). Overall, 32 LCP (67%) were implanted in a single procedure: 3 (6%) before and 13 (27%) after CIED extraction. LCP were implanted in a single procedure in 24/38 patients (63%) with infected CIED and in 8/10 patients (80%) with dysfunctional CIED. The in-hospital mortality rate was 6% (n = 3), and the survival rates at 30 days, 90 days and 1 year were 94% (n = 45/48), 90% (n = 43/48), and 85% (n = 41/48), respectively. No recurrent LCP-related mortality or infections occurred during a median follow-up of 15 (interquartile range, 12–41) months.

Conclusion
Two-thirds of LCPs could be implanted in a single procedure with CIED extraction; no recurrent infections were detected. Overall, Micra™ LCP implantation in patients requiring CIED extraction was feasible.

Graphical Abstract
A framework for virtual learning in industrial engineering education: development of a reconfigurable virtual learning factory application
Authors: Terkaj Walter , Urgo Marcello , Kovács Péter , Tóth Erik , Mondellini Marta 
Published: August 2024

AbstractAdvances in digital factory technologies are offering great potential to innovate higher education, by enabling innovative learning approaches based on virtual laboratories that increase the involvement of students while delivering realistic experiences. This article introduces a framework for the development of virtual learning applications by addressing multidisciplinary requirements. The implementation of the framework can be eased by the use of the proposed virtual learning factory application (VLFA), an open-source solution that takes advantage of virtual reality to support innovative higher-education learning activities in industrial engineering. A complete design and development workflow is described, starting from the identification of the requirements, to the design of software modules and underlying technologies, up to the final implementation. The framework and the VLFA have been tested to implement a serious game related to the design and analysis of manufacturing systems, also collecting the feedback of students and teachers.