bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Temperature‐Induced Intersite Charge Transfer Involving Cr Ions in A‐Site‐Ordered Perovskites ACu3Cr4O12 (A: La and Y).
Authors: Zhang Shoubao , Saito Takashi , Mizumaki Masaichiro , Shimakawa Yuichi 
Published: November 2014

AbstractLaCu3Cr4O12 (I) and YCu3Cr4O12 (II) are prepared by high pressure reactions of Ln2O3 (Ln: La, Y), CuO, Cr2O3, and CrO2 in the molar ratio 1:6:0.5:7 (Au capsules, 9 GPa, 900 °C, 30 min).
ChemInform Abstract: Synthesis and Properties of Lanthanide Ruthenium(III) Oxide Perovskites.
Authors: Sinclair Alexandra , Rodgers Jennifer A. , Topping Craig V. , Misek Martin , Stewart Ross D. , Kockelmann Winfried , Bos Jan‐Willem G. , Attfield J. Paul 
Published: November 2014

AbstractA series of LnRuO3 perovskites (Ln: La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Y) is synthesized from stoichiometric mixtures of Ru, RuO2, and Ln2O3 at a pressure of 10 GPa for Ln: Pr, Nd, Sm, and 11 GPa for Ln: Eu, Gd, Tb, Dy, Ho, Y (1200 °C, 15 min).
ChemInform Abstract: Postsynthetic Metalation of Bipyridyl‐Containing Metal—Organic Frameworks for Highly Efficient Catalytic Organic Transformations.
Authors: Manna Kuntal , Zhang Teng , Lin Wenbin 
Published: November 2014

AbstractTwo new solid catalysts are synthesized via metalation of the 2,2′‐bipyridyl‐derived metal—organic framework of the UiO structure (bipy‐UiO).
ChemInform Abstract: Pd‐Catalyzed Highly Regio‐, Diastereo‐, and Enantioselective Allylic Alkylation of α‐Fluorophosphonates.
Authors: Huang Ying , Zhang Qing‐Song , Fang Ping , Chen Tie‐Gen , Zhu Jun , Hou Xue‐Long 
Published: November 2014

AbstractThe resulting allylic alkylation products (III) contain two adjacent stereogenic centers and three functional groups that can be easily elaborated into more complex compounds such as oxazine (V).
ChemInform Abstract: Diastereoselective Allylation and Crotylation of N‐tert‐Butanesulfinyl Imines with Allylic Alcohols.
Authors: Barros Olga Soares do Rego , Sirvent Juan Alberto , Foubelo Francisco , Yus Miguel 
Published: November 2014

AbstractA convenient protocol for the Pd‐catalyzed allylation of chiral imines with allylic alcohols to afford the corresponding products with high diastereoselectivities is developed.
ChemInform Abstract: Chiral Magnesium(II)‐Catalyzed Asymmetric Ring‐Opening of Meso‐Aziridines with Primary Alcohols.
Authors: Li Jun , Liao Yuting , Zhang Yulong , Liu Xiaohua , Lin Lili , Feng Xiaoming 
Published: November 2014

AbstractAn efficient catalytic system is found for the asymmetric ring‐opening of meso‐aziridines with different nucleophiles, e.g. aniline, water, and methanol.
ChemInform Abstract: Nickel‐Catalyzed N‐Heterocycle‐Directed Cross‐Coupling of Fluorinated Arenes with Organozinc Reagents.
Authors: Xiao Sen‐Han , Xiong Yang , Zhang Xu‐Xue , Cao Song 
Published: November 2014

AbstractA novel Ni‐catalyzed cross‐coupling of fluoroarenes is developed using alkyl zinc reagents in the presence of sodium.
ChemInform Abstract: Iridium‐Catalyzed Regioselective Silylation of Secondary Alkyl C—H Bonds for the Synthesis of 1,3‐Diols.
Authors: Li Bijie , Driess Matthias , Hartwig John F. 
Published: November 2014

AbstractA new Ir‐catalyzed intramolecular silylation of secondary alkyl C—H bonds is reported.
ChemInform Abstract: Antibacterial Activity of Adamantyl Substituted Cyclohexane Diamine Derivatives Against Methicillin Resistant Staphylococcus aureus and Mycobacterium tuberculosis.
Authors: Beena Beena , Kumar Deepak , Kumbukgolla Widuranga , Jayaweera Sampath , Bailey MaiAnn , Alling Torey , Ollinger Juliane , Parish Tanya , Rawat Diwan S. 
Published: November 2014

AbstractA series of 42 of title compounds [(I) and (II), e.g.] are synthesized and tested against 29 strains of S.
ChemInform Abstract: Gold‐Catalyzed Tandem Diels—Alder Reactions of Enynals/Enynones with Alkenes: Generation and Trapping of Cyclic o‐QDMs.
Authors: Zhu Shifa , Hu Lang , Jiang Huanfeng 
Published: November 2014

AbstractThe reaction proceeds through the trapping of cyclic o‐quinodimethane (cyclic‐o‐QDM) with electron‐deficient dienophiles [e.g. (III)] to afford unstable cyclohexene‐1,4‐diones, which can be oxidized into the 1,4‐benzoquinone on silica gel.
ChemInform Abstract: Palladium‐Catalyzed Aerobic Oxidative Allylic C—H Arylation of Alkenes with Polyfluorobenzenes.
Authors: Jiang Huanfeng , Yang Wanfei , Chen Huoji , Li Jianxiao , Wu Wanqing 
Published: November 2014

AbstractAn aerobic oxidative cross‐coupling reaction of alkenes with polyfluorobenzenes through Pd‐catalyzed C—H activation is reported.
ChemInform Abstract: Efficient Hydrogenation of Imines over Fe and ZnO Powder in a Self‐Neutralizing Acidic CO2—H2O System.
Authors: Ma Ran , He Liang‐Nian , Song Qing‐Wen , Zhou Yue‐Biao , Liu Kai‐Xuan 
Published: November 2014

AbstractHydrogenation of imines [(I) and (III)] is accomplished using an environmentally benign process in the reversible CO2—H2O system where water is thought to be the terminal hydrogen source.
ChemInform Abstract: Mn‐Catalyzed Three‐Component Reactions of Imines/Nitriles, Grignard Reagents, and Tetrahydrofuran: An Expedient Access to 1,5‐Amino/Keto Alcohols.
Authors: He Ruoyu , Jin Xiqing , Chen Hui , Huang Zhi‐Tang , Zheng Qi‐Yu , Wang Congyang 
Published: November 2014

AbstractThis unusual reaction is performed in tetrahydrofuran which is split during the reaction in an unprecedented manner under conditions used, leading to the formation of two geminal C—C bonds via C—H and C—O cleavage.
ChemInform Abstract: Synthesis of Stable Aromatic and Heteroaromatic Sulfonyl‐Amidoximes and Evaluation of Their Antioxidant and Lipid Peroxidation Activity.
Authors: Doulou Ismini , Kontogiorgis Christos , Koumbis Alexandros E. , Evgenidou Eleni , Hadjipavlou‐Litina Dimitra , Fylaktakidou Konstantina C. 
Published: November 2014

AbstractEvaluation of antioxidant activities shows that most of the compounds (III) synthesized (17 out of 28 compounds) highly compete with DMSO for hydroxyl radicals, while five of them, e.g. compounds (IIIa), (IIId) and (IIIg), inhibit lipid peroxidation.
ChemInform Abstract: Hydrotrifluoromethylthiolation of α‐Diazo Esters — Synthesis of α‐SCF3 Substituted Esters.
Authors: Lefebvre Quentin , Fava Eleonora , Nikolaienko Pavlo , Rueping Magnus 
Published: November 2014

AbstractThe reaction of aryldiazoacetates (I) with copper trifluoromethylthiolate (II) affords desired α‐(trifluoromethylthio)esters (III).
ChemInform Abstract: Imidazolium‐Functionalized β‐Cyclodextrin as a Highly Recyclable Multifunctional Ligand in Water.
Authors: Kairouz Vanessa , Schmitzer Andreea R. 
Published: November 2014

AbstractThe synthesis and catalytic properties of a novel dodecyl‐imidazolium modified β‐cyclodextrin (DIC) in the Suzuki—Miyaura coupling are reported.
ChemInform Abstract: Application of Bisphosphomide‐Palladium(II) Pincer Complex in Suzuki—Miyaura Cross‐Coupling Reaction under Microwave Irradiation.
Authors: Kumaravel Maruthai , Kumar Pawan , Balakrishna Maravanji S. 
Published: November 2014

AbstractThe catalyst exhibits very high catalytic activity in the Suzuki—Miyaura cross‐coupling reaction of various aryl bromides with aryl boronic acids.
ChemInform Abstract: Benzylation of Arenes with Benzyl Ethers Promoted by the in situ Prepared Superacid BF3—H2O.
Authors: Li Yu , Xiong Yan , Li Xueming , Ling Xuege , Huang Ruofeng , Zhang Xiaohui , Yang Jianchun 
Published: November 2014

AbstractA wide variety of diarylmethanes is synthesized by the title reaction.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Umpolung of Styrenes: Mechanistic Elucidation and Selective Tail‐to‐Tail Dimerization.
Authors: Schedler Michael , Wurz Nathalie E. , Daniliuc Constantin G. , Glorius Frank 
Published: November 2014

AbstractThe reaction between N‐heterocyclic carbenes and styrenes yields alkyl‐substituted azolium salts, which are able to form nucleophilic deoxy Breslow intermediates by simple deprotonation.
ChemInform Abstract: Copper‐Catalyzed Oxidative Cyclization of 1,5‐Enynes with Concomitant C—C Bond Cleavage: An Unexpected Access to 3‐Formyl‐1‐indenone Derivatives.
Authors: Zhang Jian , Wu Degui , Chen Xiaoling , Liu Yunkui , Xu Zhenyuan 
Published: November 2014

AbstractA novel water‐induced oxygen‐insertion/β‐carbon elimination via double oxy‐cupration is proposed to be involved in the C—C bond cleavage step.
ChemInform Abstract: 2,2,2‐Trifluoroacetophenone: An Organocatalyst for an Environmentally Friendly Epoxidation of Alkenes.
Authors: Limnios Dimitris , Kokotos Christoforos G. 
Published: November 2014

Abstract2,2,2‐Trifluoroacetophenone is found to be an efficient catalyst for epoxidation of alkenes providing a mild, fast, and inexpensive formation of a wide range of oxiranes.
ChemInform Abstract: Group‐Assisted Purification (GAP) Chemistry for Dihydrofurans: Water as a Medium for Catalyst Free Synthesis in a One Pot Four Component Reaction.
Authors: Chennapuram Madhu , Emmadi Narender Reddy , Bingi Chiranjeevi , Nanubolu Jagadeesh Babu , Atmakur Krishnaiah 
Published: November 2014

AbstractThe reaction of chromene derivatives (I) with NCS affords dihydrofurans (III) after an unusual rearrangement in good yields.
ChemInform Abstract: Dihydrothiophenes Containing Quaternary Stereogenic Centres by Sequential Stereospecific Rearrangements and Ring‐Closing Metathesis.
Authors: Mingat Gaelle , McDouall Joseph J. W. , Clayden Jonathan 
Published: November 2014

AbstractThe reaction of alcohol (I) with N,N′‐thiocarbonyldiimidazole is accompanied by a [3,4]‐sigmatropic rearrangement to afford imidazoles (III), which are readily converted into thiocarbamates (V).
ChemInform Abstract: Logical Design and Synthesis of indole‐2,3‐diones and 2‐Hydroxy‐3(2H)‐benzofuranones via One‐Pot Intramolecular Cyclization.
Authors: Gao Fang‐Fang , Xue Wei‐Jian , Wang Jun‐Gang , Wu An‐Xin 
Published: November 2014

AbstractA new method to synthesize indole‐2,3‐diones and 2‐hydroxy‐3(2H)‐benzofuranones is developed via a one‐stop oxidative cyclization of the corresponding ortho‐functionalized acetophenones (I) and (III).
ChemInform Abstract: Synthesis of Carbazoles by Copper‐Catalyzed Intramolecular C—H/N—H Coupling.
Authors: Takamatsu Kazutaka , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: November 2014

AbstractThe picolinamide‐based directing group is essential for the intramolecular coupling of 2‐aminobiphenyls to give the corresponding carbazole derivatives.
ChemInform Abstract: B(C6F5)3 Promoted Cyclization of Internal Propargyl Esters: Structural Characterization of 1,3‐Dioxolium Compounds.
Authors: Hansmann Max M. , Melen Rebecca L. , Rominger Frank , Hashmi A. Stephen K. , Stephan Douglas W. 
Published: November 2014

AbstractThe products are remarkably stable toward moisture and temperature allowing the characterization of (IIIa) and (IIIb) by X‐ray analysis.
ChemInform Abstract: Synthesis of 1‐Aryl‐4‐tosyl‐5‐(trifluoromethyl)‐1H‐imidazoles.
Authors: Bunev Alexander S. , Vasiliev Maksim A. , Statsyuk Vladimir E. , Ostapenko Gennady I. , Peregudov Alexander S. 
Published: November 2014

AbstractA novel and improved method for the synthesis of the title imidazoles (III) (9 examples) based on the van Leusen reaction is given.
ChemInform Abstract: Highly Regioselective Palladium‐Catalyzed Direct Alkenylation of Thiazolo[3,2‐b]‐1,2,4‐triazoles via C—H Activation.
Authors: Liu Wenjie , Wang Shaohua , Zhan Haiying , Lin Juan , He Peiling , Jiang Yi 
Published: November 2014

AbstractThe Pd‐catalyzed oxidative coupling of thiazolotriazoles and alkenes proceeds with high regio‐ and stereoselectivity to produce (E)‐isomers (III) and (V) exclusively.
ChemInform Abstract: Synthesis of Some Novel 1,2,4‐Triazol‐3‐one Derivatives Bearing the Salicyl Moiety and Their Anticonvulsant Activities.
Authors: Kahveci Bahittin , Mentese Emre , Akkaya Emre , Yilmaz Fatih , Dogan Inci S. , Oezel Arzu 
Published: November 2014

AbstractSome of the title compounds (III) show significant anticonvulsant activity in MES‐induced seizure test.
ChemInform Abstract: Efficient and Convenient Protocol for the Synthesis of 3,5‐Disubstituted 1,2,4‐Oxadiazoles Using HClO4‐SiO2 as a Heterogeneous Recyclable Catalyst.
Authors: Tadikonda Ramu , Nakka Mangarao , Gajula Mahaboob Basha , Rayavarapu Srinuvasarao , Gollamudi Padma Rao , Vidavalur Siddaiah 
Published: November 2014

AbstractThe protocol uses amidoximes (I) and acid anhydrides (II) as starting materials and provides the corresponding products (III) in good to excellent yields.
ChemInform Abstract: A Novel Synthesis of Tetra and Pentacyclic Quinolinopyran Tethered Pyrazole/Coumarin Scaffolds via a Solid State Melt Reaction.
Authors: Bakthadoss Manickam , Kannan Damodharan 
Published: November 2014

AbstractTitle structures [e.g. (III), (V), (VII), and (VIII)] are efficiently synthesized via domino Knoevenagel intramolecular hetero‐Diels—Alder strategy in a highly diastereo and regioselective fashion.
ChemInform Abstract: Synthesis of 1,4‐Dihydroquinoline Derivatives under Transition‐Metal‐Free Conditions and Their Diverse Applications.
Authors: Chu Xue‐Qiang , Zi You , Meng Hua , Xu Xiao‐Ping , Ji Shun‐Jun 
Published: November 2014

AbstractTetrahydroacridinone derivatives [(III) and (V)] are synthesized via intermolecular cascade cyclization in a one‐pot protocol.
ChemInform Abstract: Synthesis of New Heterocyclic Compounds Using 2‐(3,3‐Dimethyl‐1H‐pyrroloisoquinolin‐2(3H)‐ylidene)malonaldehydes.
Authors: Afghan Arash , Roohi Laia , Baradarani Mehdi M. , Joule John A. 
Published: November 2014

AbstractMalondialdehyde derivative (III) is used for the synthesis of the new heterocycles (V), (VII), and (VIII).
ChemInform Abstract: Synthesis of Spiro[isoquinolinone‐4,2′‐oxiranes] and Isoindolinones via a Multicomponent Reaction of 2‐Acetyl‐oxirane‐2‐carboxamides, Arylaldehydes and Malononitrile.
Authors: Liu Bing , Wei Enxiang , Lin Shaoxia , Zhao Baozhong , Liang Fushun 
Published: November 2014

AbstractDepending on different intramolecular hydrogen bonding modes in diastereomeric 2‐acetyl‐oxirane‐2‐carboxamides (I) and (V), title compounds (IV) and (VI), resp., are formed in the multicomponent reaction with aryl aldehydes (II) and malodinitrile (III).
ChemInform Abstract: Combining a Click—Multicomponent Reaction: One‐Pot Synthesis of (1,2,3‐Triazol‐4‐yl)methyl‐3‐amino‐5,10‐dihydro‐5,10‐dioxo‐1H‐pyrazolo [1,2‐b]phthalazine‐2‐carboxylate Derivatives.
Authors: Dabiri Minoo , MaGee David , Salehi Peyman , Torkian Laleh , Fakharian Mahsa , Donahue Jordan 
Published: November 2014

AbstractThe title compounds (V) are obtained by a four‐component, one‐pot condensation of benzaldehyde derivatives, an active methylene compound, azides, and phthalhydrazide.
ChemInform Abstract: Studies on the Biginelli Reactions of Salicylaldehyde and 2‐Hydroxy‐1‐naphthaldehyde.
Authors: Liu Qingjian , Xu Jiehua , Teng Fei , Chen Anjun , Pan Ning , Zhang Wenwen 
Published: November 2014

AbstractChemoselectivity of the Biginelli Reactions depends on the reaction conditions used, tricyclic bridged pyrimidine derivatives are formed upon refluxing whereas, at lower temperatures pyrimidine derivatives of type (IV) are formed.
ChemInform Abstract: An Unexpected Oxidative Decarboxylation Reaction of 2,3‐Dihydroxybenzoic Acid in the Synthesis of New Dibenzyltetrahydroquinoxalinediones.
Authors: Habibi Davood , Nematollahi Davood , Meshkinghalam Sahereh , Varmaghani Fahimeh 
Published: November 2014

AbstractOxidation of catechols in the presence of N,N′‐dibenzylethylenediamines produces novel tetrahydroquinoxalinediones.
ChemInform Abstract: Microwave‐Assisted Synthesis of Substituted Dibenzo[b,f][1,4]thiazepines, Dibenzo[b,f][1,4]oxazepines, Benzothiazoles, and Benzimidazoles.
Authors: Lin Yu‐Chin , Li Ni‐Ching , Cherng Yie‐Jia 
Published: November 2014

AbstractTitle thiazepine and oxazepine derivatives are efficiently synthesized using a one‐pot procedure, whereas the analogous reaction of o‐aminothiophenol or o‐phenylenediamine in the absence of base leads to benzothiazoles and benzimidazoles, respectively.
ChemInform Abstract: A Catalytic Enantiotopic‐Group‐Selective Suzuki Reaction for the Construction of Chiral Organoboronates.
Authors: Sun Chunrui , Potter Bowman , Morken James P. 
Published: November 2014

AbstractThe conversion of achiral geminal bis(pinacolboronates) into chiral organoboronates proceeds in the presence of a chiral monodentate taddol‐derived phosphoramidite ligand and occurs with high enantioselectivity.
ChemInform Abstract: Silylium Ion‐Promoted Dehydrogenative Cyclization: Synthesis of Silicon‐Containing Compounds Derived from Alkynes.
Authors: Arii Hidekazu , Kurihara Takashi , Mochida Kunio , Kawashima Takayuki 
Published: November 2014

AbstractThe cyclization of silanes (I) with alkynes (II) in the presence of a pyridine base and a slight excess of tritylium tetrakis(pentafluorophenyl)borate leads to 2‐silanaphthalenes (III), whilst the reaction in the presence of a catalytic amount of borate and without base affords tetrahydro‐2‐silanaphthalenes (IV).
ChemInform Abstract: The Efficient Method for the Preparation of Alkenylsilanes from Organoaluminums.
Authors: Kadikova Rita N. , Zosim Tat'yana P. , Dzhemilev Usein M. , Ramazanov Ilfir R. 
Published: November 2014

AbstractThe reaction of alkynes with trimethylaluminum or iBu2AlH gives 1‐alkenylaluminum intermediates which are readily trapped by sulfonic acid silyl esters to produce vinyl silanes in good yields.
ChemInform Abstract: Synthesis and Neurite Outgrowth Promoting Activity of Vibsanin B Derivatives.
Authors: Shao Li‐Dong , Xu Jun , Gao Xiu , He Juan , Zhao Yu , Peng Li‐Yan , Luo Huai‐Rong , Xia Chengfeng , Zhao Qin‐Shi 
Published: November 2014

AbstractA series of vibsane‐type diterpenoids with promising neurite outgrowth promoting activity is prepared from vibsanin B (I).
ChemInform Abstract: Polyketides from the Mangrove‐Derived Endophytic Fungus Acremonium strictum.
Authors: Hammerschmidt Lena , Debbab Abdessamad , Ngoc Tu Duong , Wray Victor , Hemphil Catalina Perez , Lin WenHan , Broetz‐Oesterhelt Heike , Kassack Matthias U. , Proksch Peter , Aly Amal H. 
Published: November 2014

AbstractThe absolute configuration of compound (I) is determined using a modified Mosher method.
ChemInform Abstract: “The Green Side of the Moon: Ecofriendly Aspects of Organoselenium Chemistry”
Authors: Santoro Stefano , Azeredo Juliano B. , Nascimento Vanessa , Sancineto Luca , Braga Antonio L. , Santi Claudio 
Published: November 2014

AbstractReview: [key aspects for the development of a greener synthesis and the use of organoselenium compounds; 98 refs.
ChemInform Abstract: Metal Nanoparticles and Supramolecular Macrocycles: A Tale of Synergy
Authors: Montes‐Garcia Veronica , Perez‐Juste Jorge , Pastoriza‐Santos Isabel , Liz‐Marzan Luis M. 
Published: November 2014

AbstractReview: [symmary on current reseach dealing with the combination of noble‐metal nanoparticles and different families of supramolecular macrocycles (cyclodextrins, cucurbit[n]urils, calixarenes, and pillar[n]arenes); 80 refs.].
ChemInform Abstract: The Uniqueness and Therapeutic Value of Natural Products from West African Medicinal Plants. Part 2. Terpenoids, Geographical Distribution and Drug Discovery
Authors: Ntie‐Kang Fidele , Lifongo Lydia L. , Simoben Conrad V. , Babiaka Smith B. , Sippl Wolfgang , Mbaze Luc Meva'a 
Published: November 2014

AbstractReview: 172 refs.
Influence of Glutamic Acid Enantiomers on C‐mineralization
Authors: Formánek Pavel , Vranová Valerie , Lojková Lea 
Published: November 2014

AbstractSeasonal dynamics in the mineralization of glutamic acid enantiomers in soils from selected ecosystems was determined and subjected to a range of treatments: ambient x elevated CO2 level and meadow x dense x thinned forest environment. Mineralization of glutamic acid was determined by incubation of the soil with 2 mg L‐ or D‐glutamic acid g‐1 of dry soil to induce the maximum respiration rate. Mineralization of glutamic acid enantiomers in soils fluctuates over the course of a vegetation season, following a similar trend across a range of ecosystems. Mineralization is affected by environmental changes and management practices, including elevated CO2 level and thinning intensity. L‐glutamic acid metabolism is more dependent on soil type as compared to metabolism of its D‐enantiomer. The results support the hypothesis that the slower rate of D‐ compared to L‐ amino acid mineralization is due to different roles in anabolism and catabolism of the soil microbial community. Chirality 27:104–108, 2015. © 2014 Wiley Periodicals, Inc.
Stirring and Stirred‐Tank Reactors
Authors: Nienow Alvin W. 
Published: November 2014

AbstractStirred‐tank reactors are used throughout the process industry. They are not only applied in the chemical industry, but also in newer industrial sectors, such as biologics, pharmaceuticals, nanotechnology, and regenerative medicine. Certain features have not changed for many years, but the understanding of the physical processes occurring within has greatly increased. Since knowledge of the interaction between the physics of mixing, single‐ or multiphase, and the underlying science is critical, the physical processes of mixing/stirring are considered as they developed over the last ∼75 years.
Predictors of health care utilization in adult survivors of childhood cancer exposed to central nervous system–directed therapy
Authors: Kimberg Cara I. , Klosky James L. , Zhang Nan , Brinkman Tara M. , Ness Kirsten K. , Srivastava Deo Kumar , Robison Leslie L. , Hudson Melissa M. , Krull Kevin R. 
Published: November 2014

BACKGROUNDSurvivors of childhood cancer treated with central nervous system (CNS)–directed therapy may be at risk for poor health care utilization because of neurocognitive deficits. This study examined associations between neurocognitive function and adherence to routine and risk‐based medical evaluations in adult survivors exposed to CNS‐directed therapy.METHODSNeurocognitive function and health care utilization were assessed in 1304 adult survivors of childhood cancer enrolled in the St. Jude Lifetime Cohort Study. Adherence to recommended care was defined as meeting guidelines published by the Children's Oncology Group. Multivariate models were used to evaluate associations between neurocognitive function and health screenings. Established predictors of health care utilization were included as covariates. Odds ratios (ORs) or prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated for variables maintained in the final models.RESULTSAdherence to recommended medical care was higher for routine care (general physician care, 57.6%; dental care, 49.1%) versus specialized care (survivor‐focused care, 21.9%; echocardiogram, 19.9%). Higher intelligence was predictive of general physician care (OR, 1.74; 95% CI, 1.41‐2.15) and survivor‐focused care (OR, 1.44; 95% CI, 1.13‐1.83) in comparison with no care, whereas better executive function skills were associated with reduced dental care (PR, 0.94; 95% CI, 0.91‐0.98). Echocardiogram monitoring was not associated with neurocognition. Possible late effects of cancer treatment (pain and reduced cardiorespiratory fitness) were associated with an increased likelihood of receiving specialized medical care.CONCLUSIONSSurvivors with reduced global cognition are at risk for poor health care utilization. Educational practices regarding recommended health care should be personalized to ensure comprehension by survivors with neurocognitive impairment. Cancer 2015;121:774–782. © 2014 American Cancer Society.