bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of sodium borocaptate (BSH) and boronophenylalanine (BPA) as boron delivery agents for neutron capture therapy (NCT) of cancer: an update and a guide for the future clinical evaluation of new boron delivery agents for NCT
Authors: Barth Rolf F. , Gupta Nilendu , Kawabata Shinji 
Published: July 2024

AbstractBoron neutron capture therapy (BNCT) is a cancer treatment modality based on the nuclear capture and fission reactions that occur when boron‐10, a stable isotope, is irradiated with neutrons of the appropriate energy to produce boron‐11 in an unstable form, which undergoes instantaneous nuclear fission to produce high‐energy, tumoricidal alpha particles. The primary purpose of this review is to provide an update on the first drug used clinically, sodium borocaptate (BSH), by the Japanese neurosurgeon Hiroshi Hatanaka to treat patients with brain tumors and the second drug, boronophenylalanine (BPA), which first was used clinically by the Japanese dermatologist Yutaka Mishima to treat patients with cutaneous melanomas. Subsequently, BPA has become the primary drug used as a boron delivery agent to treat patients with several types of cancers, specifically brain tumors and recurrent tumors of the head and neck region. The focus of this review will be on the initial studies that were carried out to define the pharmacokinetics and pharmacodynamics of BSH and BPA and their biodistribution in tumor and normal tissues following administration to patients with high‐grade gliomas and their subsequent clinical use to treat patients with high‐grade gliomas. First, we will summarize the studies that were carried out in Japan with BSH and subsequently at our own institution, The Ohio State University, and those of several other groups. Second, we will describe studies carried out in Japan with BPA and then in the United States that have led to its use as the primary drug that is being used clinically for BNCT. Third, although there have been intense efforts to develop new and better boron delivery agents for BNCT, none of these have yet been evaluated clinically. The present report will provide a guide to the future clinical evaluation of new boron delivery agents prior to their clinical use for BNCT.
Impact of genomic and epigenomic alterations of multigene on a multicancer pedigree
Authors: Gao Jingyu , Wu Yongzhang , Yu Jieming , Qiu Yinbin , Yi Tiantian , Luo Chaochao , Zhang Junxiao , Lu Gary , Li Xu , Xiong Fu , Wu Xuedong , Pan Xinghua 
Published: July 2024

AbstractBackgroundGermline mutations have been identified in a small number of hereditary cancers, but the genetic predisposition for many familial cancers remains to be elucidated.MethodsThis study identified a Chinese pedigree that presented different cancers (breast cancer, BRCA; adenocarcinoma of the esophagogastric junction, AEG; and B‐cell acute lymphoblastic leukemia, B‐ALL) in each of the three generations. Whole‐genome sequencing and whole‐exome sequencing were performed on peripheral blood or bone marrow and cancer biopsy samples. Whole‐genome bisulfite sequencing was conducted on the monozygotic twin brothers, one of whom developed B‐ALL.ResultsAccording to the ACMG guidelines, bioinformatic analysis of the genome sequencing revealed 20 germline mutations, particularly mutations in the DNAH11 (c.9463G > A) and CFH (c.2314G > A) genes that were documented in the COSMIC database and validated by Sanger sequencing. Forty‐one common somatic mutated genes were identified in the cancer samples, displaying the same type of single nucleotide substitution Signature 5. Meanwhile, hypomethylation of PLEK2, MRAS, and RXRA as well as hypermethylation of CpG island associated with WT1 was shown in the twin with B‐ALL.ConclusionsThese findings reveal genomic alterations in a pedigree with multiple cancers. Mutations found in the DNAH11, CFH genes, and other genes predispose to malignancies in this family. Dysregulated methylation of WT1, PLEK2, MRAS, and RXRA in the twin with B‐ALL increases cancer susceptibility. The similarity of the somatic genetic changes among the three cancers indicates a hereditary impact on the pedigree. These familial cancers with germline and somatic mutations, as well as epigenomic alterations, represent a common molecular basis for many multiple cancer pedigrees.
DEB‐TACE versus cTACE for unresectable HCC with B1‐type bile duct invasion after successful biliary drainage: A propensity score matching analysis
Authors: Fan Wenzhe , Zheng Xinlin , Zhao Xiao , Zhu Bowen , Wu Yanqin , Xue Miao , Tang Rong , Huang Zhen , Qiao Liangliang , Lu Mingjian , Tang Yiyang , Wu Jian , Li Jiaping 
Published: July 2024

AbstractBackgroundTransarterial chemoembolization (TACE) is the standard treatment for intermediate‐stage hepatocellular carcinoma (HCC). Given the lack of specific recommendations for conventional TACE (cTACE) and drug‐eluting bead TACE (DEB‐TACE) in patients having unresectable HCC with tumor infiltrating the common hepatic duct or the first‐order branch of the bile ducts (B1‐type bile duct invasion; B1‐BDI) after biliary drainage, we retrospectively compared the safety and efficacy of DEB‐TACE with cTACE in this patient population.Materials and MethodsUsing data from five tertiary medical centers (January 2017–December 2021), we compared complications, overall survival (OS), time to progression (TTP), and tumor response rate between patients having unresectable HCC with B1‐BDI who underwent DEB‐TACE or cTACE after successful biliary drainage. X‐tile software calculated the pre‐TACE total bilirubin (TBil) cutoff value, indicating optimal timing for sequential TACE after drainage. Propensity score matching (PSM) was performed.ResultsThe study included 108 patients with unresectable HCC (B1‐BDI) who underwent DEB‐TACE and 114 who received cTACE as initial treatment. After PSM (n = 53 for each group), the DEB‐TACE group had a longer TTP (8.9 vs. 6.7 months, p = 0.038) and higher objective response rate (64.2% vs. 39.6%, p = 0.011) than did the cTACE group, although OS was comparable (16.7 vs. 15.3 months, p = 0.115). The DEB‐TACE group exhibited fewer post‐procedural increments in the mean albumin‐bilirubin score, TBil, and alanine aminotransferase (ALT), along with a significantly lower incidence of serious adverse events within 30 days (hepatic failure, ALT increase, and TBil increase) than the cTACE group (all p < 0.05). The pre‐TACE TBil cutoff value was 99 μmol/L; patients with higher values (>99 μmol/L) had poorer OS in both groups (p < 0.05).ConclusionDEB‐TACE is safe and effective after successful biliary drainage in unresectable HCC with B1‐BDI, potentially better than cTACE in terms of liver toxicity, TTP, and ORR. Lowering TBil below 99 μmol/L through successful drainage may create ideal conditions for sequential TACE.
Does personal therapy predict better trainee effectiveness?
Authors: Li Xu , Wang Yuanming , Li Feihan 
Published: July 2024

AbstractObjectivesThe aim of this study was to examine whether the history of personal therapy among therapist trainees predicts their clinical effectiveness in terms of client symptom reduction.MethodsTwo anonymous archived datasets from a longitudinal research project on mental health counselling training in China were used. Both datasets included trainee‐reported history of personal therapy and their client‐reported symptom levels prior to each counselling session.ResultsUsing multilevel modelling, we found that, in Dataset 1, neither of the personal therapy variables (whether trainees had undergone personal therapy nor number of personal therapy hours) significantly predicted trainees' client symptom outcome. Dataset 2, which included whether trainees were satisfied with their personal therapy, showed that more hours of unsatisfactory personal therapy for a trainee were associated with decreased average client symptom improvement, whereas more hours of highly satisfactory personal therapy for a trainee were associated with greater client symptom improvement.ConclusionsFindings in this study suggested that the association between trainees' personal therapy length and their clinical effectiveness may be moderated by the quality of their personal therapy: Whereas satisfactory personal therapy might be beneficial in the trainee's clinical work, longer unsatisfactory personal therapy was associated with decreased trainee effectiveness. Research limitations and implications for training are discussed.
Online health information seeking, health anxiety and cyberchondria among men who engage in sexual risk taking: The mediating role of medical consultation about HIV/AIDS
Authors: Guo Yu , Wang Yuxuan , Li Yiwei 
Published: July 2024

AbstractThe rapid development of electronic communication technology has brought about a revolutionary transformation in health information seeking and medical consultation. Beyond traditional avenues like seeking assistance from doctors in hospitals, individuals now have the option to engage in online medical consultations, enhancing their ability to manage routine health effectively. However, an overreliance on online medical consultations driven by heightened health anxiety may contribute to the surge in online health information inquiries, a phenomenon positively associated with the emergence of cyberchondria. In the context of China, where HIV/AIDS is socially stigmatised, cyberchondria related to HIV infection becomes particularly noteworthy. This study delves into the potential consequences of online health information seeking (OHIS) with a specific focus on Kongai BBS, a platform catering for individuals with a fear of AIDS. Our research collected data from 309 male users actively participating in the BBS, who had engaged in high‐risk sexual behaviours in the past 6 months. Applying structural equation modelling (SEM), this study examines the intricate relationships between OHIS, health anxiety, online and offline medical consultations, and cyberchondria. The results indicate that online medical consultation serves as a mediator in the relationship between OHIS and cyberchondria, whereas offline medical consultation does not significantly impact this relationship. These findings contribute valuable insights into the interactive dynamics between online and offline medical consultations, offering practical implications for the prevention of HIV infection in China. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Review of computer‐assisted diagnosis model to classify follicular lymphoma histology
Authors: Saxena Pranshu , Aggarwal Sahil Kumar , Sinha Amit , Saxena Sandeep , Singh Arun Kumar 
Published: July 2024

AbstractThe field of image processing is experiencing significant advancements to support professionals in analyzing histological images obtained from biopsies. The primary objective is to enhance the process of diagnosis and prognostic evaluations. Various forms of cancer can be diagnosed by employing different segmentation techniques followed by postprocessing approaches that can identify distinct neoplastic areas. Using computer approaches facilitates a more objective and efficient study of experts. The progressive advancement of histological image analysis holds significant importance in modern medicine. This paper provides an overview of the current advances in segmentation and classification approaches for images of follicular lymphoma. This research analyzes the primary image processing techniques utilized in the various stages of preprocessing, segmentation of the region of interest, classification, and postprocessing as described in the existing literature. The study also examines the strengths and weaknesses associated with these approaches. Additionally, this study encompasses an examination of validation procedures and an exploration of prospective future research roads in the segmentation of neoplasias.
Elevating Oxygen Evolution using Iron Phthalocyanine Infused Vanillic acid Electrocatalyst
Authors: Patil Gouthami , Daniel Shantharaja , Koodlur Sannegowda Lokesh 
Published: July 2024

AbstractOxygen evolution reaction (OER) is the bottle neck step in water splitting reaction towards the realization of hydrogen based clean energy production and storage. Metal air batteries and polymer electrolyte membrane fuel cells (PEMFC) are the alternative green energy systems that utilise O2 and H2 in the production of continuous and high energy output without the utilization of carbon based fuels which are the major sources of pollution. Transition metal based N4 organics are explored extensively as oxygen electrocatalysts i. e., OER and oxygen reduction reaction (ORR) catalysts because of their ease of synthesis, tuneable properties, low cost and high performance with long term stability. Here, vanillic acid functionalized iron phthalocyanine (FeVAPc) was synthesised and characterised by various spectroscopic techniques. The novel FeVAPc exhibited good thermal stability and was coated on Ni foam for OER studies. The scanning electron microscopy images showed net‐work like surface morphology and the X‐ray photoelectron spectroscopy indicated the presence of Fe in +3 oxidation state. The Ni/FeVAPc demonstrated excellent electrocatalytic activity for OER with overpotential of 312 mV at 10 mA.cm−2 current density in 1.0 M KOH electrolyte. The designed organic based catalyst exhibited lesser Tafel slope value which is nearer to the benchmark catalyst, IrO2. The proposed catalyst exhibited good stability as phthalocyanines are highly stable and do not undergo decomposition even in strong acidic and basic corrosive media. Integration of FeVAPc onto the Ni foam resulted in higher mass activity, lower charge transfer resistance, high active surface area leading to enhanced conductivity and activity. The fabricated Ni/FeVAPc is an appropriate cost‐effective, efficient and stable catalyst for OER towards industrial applications.
Gold Nanoclusters Whose Photoluminescent Properties are Dynamically Tunable by Modulating the Assembly Pathway Complexity
Authors: Shen Jinglin , Zhou Fengjie , Yu You , Zhang Ensheng , Qi Wei , Zhang Yongjie 
Published: July 2024

AbstractModulating the assembly pathway is an indispensable strategy for optimizing the performance of optical materials. However, implementing this strategy is nontrivial for metal nanocluster building blocks, due to the limited functional modification of nanoclusters and complexity of their emission mechanism. In this report, we demonstrate that a gold nanocluster modified by 4,6‐diamino‐2‐pyrimidinethiol (DPT‐AuNCs) self‐assembles into two distinct aggregation structures in methanol (MeOH)/water mixed solvent, thus exhibiting pathway complexity. Kinetic studies show that DPT‐AuNCs firstly assembles into non‐luminescent nanofibers (kinetically controlled), which further transforms into strongly luminescent microflowers (thermodynamically controlled). In‐depth analysis of the assembly mechanism reveals that the transformation of aggregation structures involves the disassembly of nanofibers and a subsequent nucleation‐growth process. Temperature‐dependent photoluminescence (PL) spectroscopy and infrared (IR) measurements reveal that inter‐cluster hydrogen bonding bridged by solvent molecules and C−H⋅⋅⋅π interaction are the key factors for emission enhancement. The photoluminescent property of DPT‐AuNCs can be controlled by varying the cosolvent in water, enabling DPT‐AuNCs to distinguish different kind of alcohols, particularly the isomerism n‐propanol (NPA) and isopropanol (IPA). Additionally, the addition of seeds effectively regulate the assembly kinetics of DPT‐AuNCs. This study advances our understanding of assembly pathways and improves the luminescent performance of nanoclusters (NCs).
Thermochemistry of Solid‐State Formation, Structure, Optical, and Luminescent Properties of Complex Oxides Eu2MeO6 (Me–Mo, W), Eu2W2O9: A Combined Experimental and DFT Study
Authors: Seredina Yulia V. , Oreshonkov Aleksandr S. , Molokeev Maxim S. , Sedykh Alexander E. , Aleksandrovsky Aleksandr S. , Zhernakov Maksim A. , Khritokhin Nikolay A. , Azarapin Nikita O. , Glukhova Polina O. , Shelpakova Natalia A. , Müller‐Buschbaum Klaus , Denisenko Yuriy G. 
Published: July 2024

AbstractComplex oxides Eu2MeO6 (Me–Mo, W), Eu2W2O9 were obtained by a solid‐phase reaction between binary oxides. The thermodynamic and kinetic mechanisms of the reaction processes were established using a variety of physical‐chemical methods. All compounds obtained in this work crystallize in the low‐symmetry monoclinic system, forming complex framework structures, which determine a set of very valuable physical‐chemical properties. Comparison of experimental Kubelka‐Munk functions and DFT‐ calculated absorption spectra shows adequate agreement and reveals the origin of the fundamental absorption. In addition, the deficiency in DFT calculations in the part of mutual contribution of CTBs of Mo−O and W−O, from one side, and Eu−O contributions, from the other side, is reported. Calculations of absorption spectra are shown to be superior to band structure analysis in the determination of optical band gaps. Additionally, luminescent properties of Eu2MeO6 and Eu2W2O9 compounds were investigated. These studies provide a better understanding of the electronic and optical properties of the compounds Eu2MeO6 and Eu2W2O9, along with their potential applications in various areas.
Estimating the mean squared prediction error of the observed best predictor associated with small area counts: A computationally oriented approach
Authors: Nguyen Thuan , Jiang Jiming 
Published: July 2024

AbstractWe consider estimation of the mean squared prediction error (MSPE) for observed best prediction (OBP) in small area estimation with count data. The OBP method has been previously developed in this context by Chen et al. (Journal of Survey Statistics and Methodology, 3, 136–161, 2015). However, estimation of the MSPE remains a challenging problem due to potential model misspecification that is considered in this setting. The latter authors proposed a bootstrap method for estimating the MSPE, whose theoretical justification is not clear. We propose to use a Prasad–Rao‐type linearization method to estimate the MSPE. Unlike the traditional linearization approaches, our method is computationally oriented and easier to implement in the same regard. Theoretical properties and empirical performance of the proposed method are studied. A real‐data application is considered.
Discovery of Fluorescent Naturally‐Occurring Inhibitor of SARS‐CoV‐2 Main Protease by AIE Fluorescent Probe
Authors: Lin Hao , Zhang Chong‐Jing 
Published: July 2024

AbstractTarget‐based high‐throughput screening (HTS) is an efficient way to identify potent drugs. However, the accuracy of HTS could be affected by Pan‐Assay Interference Compounds (PAINS). One reason for the generation of PAINS is that the inherent photophysical property of screened compounds could interfere with typically used assay signals including absorption and fluorescence. Our previous studies indicate that the fluorescent probe based on the fluorophore with characteristics of aggregation‐induced emission (AIE) could provide high accuracy of HTS, especially for the fluorescent natural products. Herein, we report an AIE‐based fluorescent probe for the main protease (Mpro) of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). We designed and synthesized an AIE fluorescent probe ZLHG5, which has a site that can be specifically cleaved by Mpro to produce a light‐up fluorescence. Thanks to the large Stokes shift of AIE fluorophore (~200 nm), the probe could be effectively used for HTS of Mpro inhibitors. After screening a library of fluorescent natural products with ZLHG5, we obtained two coumarin‐originated natural compounds with potent inhibitory activity towards Mpro protease. This study provides both useful fluorescent HTS probe and potent inhibitors for Mpro protease.
Correlation Between Implant Stability Quotient and Percussion Sound Frequency
Authors: Peeraprasompong Wansiri , Aunmeungtong Weerapan , Khongkhunthian Pathawee 
Published: July 2024

ABSTRACTObjectivesTo determine the correlation between the primary implant stability quotient and the implant percussion sound frequency.Materials and MethodsA total of 14 pigs' ribs were scanned using a dental cone beam computed tomography (CBCT) scanner to classify the bone specimens into three distinct bone density Hounsfield units (HU) value categories: D1 bone: >1250 HU; D2: 850–1250 HU; D3: <850 HU. Then, 96 implants were inserted: 32 implants in D1 bone, 32 implants in D2 bone, and 32 implants in D3 bone. The primary implant stability quotient (ISQ) was analyzed, and percussion sound was recorded using a wireless microphone connected and analyzed with frequency analysis software.ResultsStatistically significant positive correlations were found between the primary ISQ and the bone density HU value (r = 0.719; p < 0.001), and statistically significant positive correlations between the primary ISQ and the percussion sound frequency (r = 0.606; p < 0.001). Furthermore, significant differences in primary ISQ values and percussion sound frequency were found between D1 and D2 bone, as well as between D1 and D3 bone. However, no significant differences were found in primary ISQ values and percussion sound frequency between D2 and D3 bone.ConclusionThe primary ISQ value and the percussion sound frequency are positively correlated.
Sex and Age Differences in Ontogeny of Alloparenting: A Relation to Forebrain DRD1, DRD2, and HTR2A mRNA Expression?
Authors: Huang Yujie , Qing Ruoting , Yang Yu , Li Ming , Gao Jun 
Published: July 2024

ABSTRACTAlloparenting refers to the practice of caring for the young by individuals other than their biological parents. The relationship between the dynamic changes in psychological functions underlying alloparenting and the development of specific neuroreceptors remains unclear. Using a classic 10‐day pup sensitization procedure, together with a pup preference and pup retrieval test on the EPM (elevated plus maze), we showed that both male and female adolescent rats (24 days old) had significantly shorter latency than adult rats (65 days old) to be alloparental, and their motivation levels for pups and objects were also significantly higher. In contrast, adult rats retrieved more pups than adolescent rats even though they appeared to be more anxious on the EPM. Analysis of mRNA expression using real‐time‐PCR revealed a higher dopamine D2 receptor (DRD2) receptor expression in adult hippocampus, amygdala, and ventral striatum, along with higher dopamine D1 receptor (DRD1) receptor expression in ventral striatum compared to adolescent rats. Adult rats also showed significantly higher levels of 5‐hydroxytryptamine receptor 2A (HTR2A) receptor expression in the medial prefrontal cortex, amygdala, ventral striatum, and hypothalamus. These results suggest that the faster onset of alloparenting in adolescent rats compared to adult rats, along with the psychological functions involved, may be mediated by varying levels of dopamine DRD1, DRD2, and HTR2A in different forebrain regions.