bluuebunny/crossref_metadata_2025_split huggingface dataset:
Older adults with cancer and common comorbidities—challenges and opportunities in improving their cancer treatment outcomes
Authors: Chen Weiwei , Altshuler Rachel D , Daschner Phil , Salvador Morales Carolina , St. Germain Diane C , Guida Jennifer , Prasanna Pataje G S , Buchsbaum Jeffrey C 
Published: July 2024

Abstract
The older American population is rapidly increasing, and millions of older adults will be cancer survivors with comorbidities. This population faces specific challenges regarding treatment and has unique clinical needs. Recognizing this need, the National Cancer Institute, in collaboration with the National Institute on Aging, hosted a webinar series, entitled Cancer, Aging, and Comorbidities. This commentary provides a reflection of 5 thematic areas covered by the webinar series, which was focused on improving cancer treatment for older adults with cancer and comorbidities: 1) the impact of comorbidities on treatment tolerability and patient outcomes; 2) the impact of comorbidities on cancer clinical trial design; 3) the development of wearable devices in measuring comorbidities in cancer treatment; 4) the effects of nutrition and the microbiome on cancer therapy; and 5) the role of senescence and senotherapy in age-related diseases. Advances have been made in these areas, however, many gaps and challenges exist and are discussed in this commentary. To improve cancer survivorship in older populations with comorbidities, aging and comorbidities must be jointly considered and incorporated across the spectrum of cancer research. This includes more basic research of the mechanisms linking comorbidities and cancer development and treatment response, building critical resources and infrastructure (eg, preclinical models and patient samples), conducting clinical trials focused on the older population, integrating geriatric assessment into cancer treatment, and incorporating novel technologies, such as wearable devices, into clinical trials and cancer care.
Results of the RVA Breathes randomized controlled trial
Authors: Everhart Robin S , Lohr Katherine D , Holder Rachel L , Morton Sarah C M , Miller Ashley , Corona Rosalie , Mazzeo Suzanne E , Thacker II Leroy R , Schechter Michael S 
Published: July 2024

Abstract

Objective
This study tested a randomized controlled trial of RVA Breathes, a community asthma program, in reducing asthma-related healthcare utilization among children living in an area with a high poverty rate.

Methods
Participants included 250 caregivers (78% African American/Black; 73.3% household income&lt;$25,000/year) and their children with asthma (5–11 years). Inclusion criteria included an asthma-related emergency department (ED) visit, hospitalization, unscheduled doctor’s visit, or systemic steroids in the past 2 years. Families were randomized to a full active intervention (asthma education with community health workers [CHWs], home remediation with home assessors, and a school nurse component; n = 118), partial active intervention (asthma education and home remediation; n = 69), or a control group (n = 63) for 9 months. Measures on healthcare utilization and asthma-related factors were collected. Follow-up assessments occurred across a 9-month period.

Results
Although we did not find any significant effects, there was a trend toward significance for a group by time effect with objective healthcare utilization as the outcome (F4,365 = 2.28, p = .061). The full intervention group experienced a significant decrease from baseline to 9-month follow-up compared with the other groups (p &lt; .001). Only the full intervention group experienced a significant increase in reported asthma action plans across time (no significant group effect).

Conclusions
In the context of the unprecedented COVID-19 pandemic, which led to a substantial global decrease in healthcare utilization, the study’s main hypotheses were not supported. Nevertheless, findings support the benefit of community asthma programs that integrate care across multiple settings and connect families with CHWs.
Data-integration with pseudoweights and survey-calibration: application to developing US-representative lung cancer risk models for use in screening
Authors: Wang Lingxiao , Li Yan , Graubard Barry I , Katki Hormuzd A 
Published: July 2024

Abstract
Accurate cancer risk estimation is crucial to clinical decision-making, such as identifying high-risk people for screening. However, most existing cancer risk models incorporate data from epidemiologic studies, which usually cannot represent the target population. While population-based health surveys are ideal for making inference to the target population, they typically do not collect time-to-cancer incidence data. Instead, time-to-cancer specific mortality is often readily available on surveys via linkage to vital statistics. We develop calibrated pseudoweighting methods that integrate individual-level data from a cohort and a survey, and summary statistics of cancer incidence from national cancer registries. By leveraging individual-level cancer mortality data in the survey, the proposed methods impute time-to-cancer incidence for survey sample individuals and use survey calibration with auxiliary variables of influence functions generated from Cox regression to improve robustness and efficiency of the inverse-propensity pseudoweighting method in estimating pure risks. We develop a lung cancer incidence pure risk model from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial using our proposed methods by integrating data from the National Health Interview Survey and cancer registries.
New insights into plasmodesmata: complex ‘protoplasmic connecting threads’
Authors: Zanini Andrea A , Burch-Smith Tessa M 
Published: July 2024

Abstract
Intercellular communication in plants, as in other multicellular organisms, allows cells in tissues to coordinate their responses for development and in response to environmental stimuli. Much of this communication is facilitated by plasmodesmata (PD), consisting of membranes and cytoplasm, that connect adjacent cells to each other. PD have long been viewed as passive conduits for the movement of a variety of metabolites and molecular cargoes, but this perception has been changing over the last two decades or so. Research from the last few years has revealed the importance of PD as signaling hubs and as crucial players in hormone signaling. The adoption of advanced biochemical approaches, molecular tools, and high-resolution imaging modalities has led to several recent breakthroughs in our understanding of the roles of PD, revealing the structural and regulatory complexity of these ‘protoplasmic connecting threads’. We highlight several of these findings that we think well illustrate the current understanding of PD as functioning at the nexus of plant physiology, development, and acclimation to the environment.
Simulations of pulsed overpressure jets: formation of bellows and ripples in galactic environments
Authors: Richards Carl , Smith Michael D 
Published: July 2024

ABSTRACT
Jets from active nuclei may supply the heating which moderates cooling and accretion from the circum-galactic medium. While steady overpressured jets can drive a circulatory flow, lateral energy transfer rarely exceeds 3 per cent of jet power, after the initial bow shock has advanced. Here, we explore if pulses in high-pressure jets are capable of sufficient lateral energy transfer into the surrounding environment. We answer this by performing a systematic survey of numerical simulations in an axisymmetric hydrodynamic mode. Velocity pulses along low Mach jets are studied at various overpressures. We consider combinations of jet velocity pulse amplitude and frequency. We find three flow types corresponding to slow, intermediate, and fast pulsations. Rapid pulsations in light jets generate a series of travelling shocks in the jet. They also create ripples which propagate into the ambient medium while a slow convection flow brings in ambient gas which is expelled along the jet direction. Long period pulses produce slowly evolving patterns which have little external effect, while screeching persists as in non-pulsed jets. In addition, rapid pulses in jets denser than the ambient medium generate a novel breathing cavity analogous to a lung. Intermediate period pulses generate a series of bows via a bellows action which transfer energy into the ambient gas, reaching power efficiencies of over 30 per cent when the jet overpressure is sufficiently large. This may adequately inhibit galaxy gas accretion. In addition, such pulses enhance the axial out-flow of jet material, potentially polluting the circum-galactic gas with metal-enriched interstellar gas.
Nearest neighbour analysis as a new probe for fuzzy dark matter
Authors: Kousha Hamed Manouchehri , Ansarifard Mohammad , Abolhasani Aliakbar 
Published: July 2024

ABSTRACT
Fuzzy dark matter (FDM) is a promising candidate for dark matter (DM), characterized by its ultra-light mass, which gives rise to wave effects at astrophysical scales. These effects offer potential solutions to the small-scale issues encountered within the standard cold dark matter (CDM) paradigm. In this paper, we investigate the large-scale structure of the cosmic web using FDM simulations, comparing them to CDM-only simulations and a simulation incorporating baryonic effects. Our study employs the nearest neighbour (NN) analysis as a new statistical tool for examining the structure and statistics of the cosmic web in an FDM universe. This analysis could capture the information absent in the two-point correlation functions. In particular, we analyse data related to the spherical contact, nearest neighbour distances (NND), and the angle between the first and second nearest neighbours of haloes (NNA). Specifically, we utilize probability distribution functions, statistical moments, and fitting parameters, as well as G(x), F(x), and J(x) functions to analyse the above data. Remarkably, the results from the FDM simulations differ significantly from the others across these analyses, while no noticeable distinction is observed between the baryonic and CDM-only simulations. Moreover, the lower FDM mass leads to more significant deviations from the CDM simulations. These compelling results highlight the efficiency of the NN analysis – mainly through the use of the J(x) function, $s_3$, $l_{3}$, and $a_4$ parameters – as a prominent new tool for investigating FDM on large scales and making observational predictions.
Hybrid GRMHD and force-free simulations of black hole accretion
Authors: Chael Andrew 
Published: July 2024

ABSTRACT
We present a new approach for stably evolving general relativistic magnetohydrodynamic (GRMHD) simulations in regions where the magnetization $\sigma =b^2/\rho c^2$ becomes large. GRMHD codes typically struggle to evolve plasma above $\sigma \approx 100$ in simulations of black hole accretion. To ensure stability, GRMHD codes will inject mass density artificially to the simulation as necessary to keep the magnetization below a ceiling value $\sigma _{\rm max}$. We propose an alternative approach where the simulation transitions to solving the equations of general relativistic force-free electrodynamics (GRFFE) above a magnetization $\sigma _{\rm trans}$. We augment the GRFFE equations in the highly magnetized region with approximate equations to evolve the decoupled field-parallel velocity and plasma energy density. Our hybrid scheme is explicit and easily added to the framework of standard-volume GRMHD codes. We present a variety of tests of our method, implemented in the GRMHD code koral, and we show results from a 3D hybrid GRMHD + GRFFE simulation of a magnetically arrested disc (MAD) around a spinning black hole. Our hybrid MAD simulation closely matches the average properties of a standard GRMHD MAD simulation with the same initial conditions in low magnetization regions, but it achieves a magnetization $\sigma \approx 10^6$ in the evacuated jet funnel. We present simulated horizon-scale images of both simulations at 230 GHz with the black hole mass and accretion rate matched to M87*. Images from the hybrid simulation are less affected by the choice of magnetization cut-off $\sigma _{\rm cut}$ imposed in radiative transfer than images from the standard GRMHD simulation.
The NIRVANDELS survey: the stellar and gas-phase mass-metallicity relations of star-forming galaxies at z = 3.5
Authors: Stanton T M , Cullen F , McLure R J , Shapley A E , Arellano-Córdova K Z , Begley R , Amorín R , Barrufet L , Calabrò A , Carnall A C , Cirasuolo M , Dunlop J S , Donnan C T , Hamadouche M L , Liu F Y , McLeod D J , Pentericci L , Pozzetti L , Sanders R L , Scholte D , Topping M W 
Published: July 2024

ABSTRACT
We present determinations of the gas-phase and stellar metallicities of a sample of 65 star-forming galaxies at $z \simeq 3.5$ using rest-frame far-ultraviolet (FUV) spectroscopy from the VANDELS survey in combination with follow-up rest-frame optical spectroscopy from VLT/KMOS and Keck/MOSFIRE. We infer gas-phase oxygen abundances ($Z_{\mathrm{g}}$; tracing O/H) via strong optical nebular lines and stellar iron abundances ($Z_{\star }$; tracing Fe/H) from full spectral fitting to the FUV continuum. Our sample spans the stellar mass range $8.5 \lt \mathrm{log}(M_{\star }/\mathrm{M}_{\odot }) \lt 10.5$ and shows clear evidence for both a stellar and gas-phase mass-metallicity relation (MZR). We find that our O and Fe abundance estimates both exhibit a similar mass-dependence, such that $\mathrm{Fe/H}\propto M_{\star }^{0.30\pm 0.11}$ and $\mathrm{O/H}\propto M_{\star }^{0.32\pm 0.09}$. At fixed $M_{\star }$ we find that, relative to their solar values, O abundances are systematically larger than Fe abundances (i.e. α-enhancement). We estimate an average enhancement of $\mathrm{(O/Fe)} = 2.65 \pm 0.16 \times \mathrm{(O/Fe)_\odot }$ which appears to be independent of $M_{\star }$. We employ analytic chemical evolution models to place a constraint on the strength of galactic-level outflows via the mass-outflow factor ($\eta$). We show that outflow efficiencies that scale as $\eta \propto M_{\star }^{-0.32}$ can simultaneously explain the functional form of of the stellar and gas-phase MZR, as well as the degree of α-enhancement at fixed Fe/H. Our results add further evidence to support a picture in which α-enhanced abundance ratios are ubiquitous in high-redshift star-forming galaxies, as expected for young systems whose interstellar medium is primarily enriched by core-collapse supernovae.
Neutral hydrogen lensing simulations in the hubble frontier fields
Authors: Blecher Tariq , Deane Roger , Obreschkow Danail , Heywood Ian 
Published: July 2024

ABSTRACT
Cold gas evolution ties the formation of dark matter haloes to the star formation history of the universe. A primary component of cold gas, neutral atomic hydrogen (HI), can be traced by its 21-cm emission line. However, the faintness of this emission typically limits individual detections to low redshifts ($z\lesssim 0.2$). To address this limitation, we investigate the potential of targeting gravitationally lensed systems. Building on our prior galaxy–galaxy simulations, we have developed a ray-tracing code to simulate lensed HI images for known galaxies situated behind the massive hubble frontier field galaxy clusters. Our findings reveal the existence of high HI mass, high HI magnification systems in these cluster-lensing scenarios. Through simulations of hundreds of sources, we have identified compelling targets within the redshift range $z\approx 0.7 - 1.5$. The most promising candidate from our simulations is the Great Arc at z = 0.725 in Abell 370, which should be detectable by MeerKAT in approximately 50 h. Importantly, the derived HI mass is predicted to be relatively insensitive to systematic uncertainties in the lensing model, and should be constrained within a factor of ${\sim }2.5$ for a 95 per cent confidence interval.
Ancestral Origins and Admixture History of Kazakhs
Authors: Lei Chang , Liu Jiaojiao , Zhang Rui , Pan Yuwen , Lu Yan , Gao Yang , Ma Xixian , Yang Yajun , Guan Yaqun , Mamatyusupu Dolikun , Xu Shuhua 
Published: July 2024

Abstract
Kazakh people, like many other populations that settled in Central Asia, demonstrate an array of mixed anthropological features of East Eurasian (EEA) and West Eurasian (WEA) populations, indicating a possible scenario of biological admixture between already differentiated EEA and WEA populations. However, their complex biological origin, genomic makeup, and genetic interaction with surrounding populations are not well understood. To decipher their genetic structure and population history, we conducted, to our knowledge, the first whole-genome sequencing study of Kazakhs residing in Xinjiang (KZK). We demonstrated that KZK derived their ancestries from 4 ancestral source populations: East Asian (∼39.7%), West Asian (∼28.6%), Siberian (∼23.6%), and South Asian (∼8.1%). The recognizable interactions of EEA and WEA ancestries in Kazakhs were dated back to the 15th century BCE. Kazakhs were genetically distinctive from the Uyghurs in terms of their overall genomic makeup, although the 2 populations were closely related in genetics, and both showed a substantial admixture of western and eastern peoples. Notably, we identified a considerable sex-biased admixture, with an excess of western males and eastern females contributing to the KZK gene pool. We further identified a set of genes that showed remarkable differentiation in KZK from the surrounding populations, including those associated with skin color (SLC24A5, OCA2), essential hypertension (HLA-DQB1), hypertension (MTHFR, SLC35F3), and neuron development (CNTNAP2). These results advance our understanding of the complex history of contacts between Western and Eastern Eurasians, especially those living or along the old Silk Road.
Narrative and Tonal Structure in Herrmann’s Score for Vertigo
Authors: Şehİraltı Oğuz 
Published: July 2024

Abstract
This article examines the relationship between tonal and narrative structures in Alfred Hitchcock’s 1958 film Vertigo. I argue that this relationship is reciprocal and that Bernard Herrmann’s score for the film affects the perception of the plot despite the generally accepted conventions of understanding film music as subordinate to overall cinematic structure. Using methodologies ranging from Schenkerian theory to analytical approaches to popular music, I suggest that the tonal structure unfolds in two broad episodes that segment the film and help us interpret it from the protagonist’s psychological perspective through the alignment of strong cadential points with important kernel events in the plot.
Hermeneutic Limits; or, When Not to Theorize: Notes for Interpreting Our Phoenix by Trans Indigenous Mexican-American Composer Mari Esabel Valverde
Authors: Lee Gavin S K 
Published: July 2024

Abstract
Trans composers, like other people marginalized by race, gender, or sexuality, are often caught in the trap of identity constructs, which both envoice minorities and also pigeonhole their possible range of musical expression. In this essay on US-based transgender Indigenous Mexican choral composer Mari Esabel Valverde, I let my consideration of “trans music theory” be guided by her view that writers have sensationalized trans identity, and that while she celebrates trans lives in her choral work Our Phoenix (2016), she is not attempting to create music that “sounds” transgender. With Valverde in mind, I construct an intersectional interpretive framework that calls for various kind of limits (the limits of queering, of authorial subjectivity, and of the notion of “unconscious” expression of identity) and proposes essential conditions (the centrality of the voices, bodies, and musical structures of trans composers) that create an ethical environment for a compassionate trans music theory to emerge.
Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference
Authors: Lobo Vivian , Nowak Iwona , Fernandez Carola , Correa Muler Ana Iris , Westholm Jakub O , Huang Hsiang-Chi , Fabrik Ivo , Huynh Hang T , Shcherbinina Evgeniia , Poyraz Melis , Härtlova Anetta , Benhalevy Daniel , Angeletti Davide , Sarshad Aishe A 
Published: July 2024

Abstract
In mammals, RNA interference (RNAi) was historically studied as a cytoplasmic event; however, in the last decade, a growing number of reports convincingly show the nuclear localization of the Argonaute (AGO) proteins. Nevertheless, the extent of nuclear RNAi and its implication in biological mechanisms remain to be elucidated. We found that reduced Lamin A levels significantly induce nuclear influx of AGO2 in SHSY5Y neuroblastoma and A375 melanoma cancer cell lines, which normally have no nuclear AGO2. Lamin A KO manifested a more pronounced effect in SHSY5Y cells compared to A375 cells, evident by changes in cell morphology, increased cell proliferation, and oncogenic miRNA expression. Moreover, AGO fPAR-CLIP in Lamin A KO SHSY5Y cells revealed significantly reduced RNAi activity. Further exploration of the nuclear AGO interactome by mass spectrometry identified FAM120A, an RNA-binding protein and known interactor of AGO2. Subsequent FAM120A fPAR-CLIP, revealed that FAM120A co-binds AGO targets and that this competition reduces the RNAi activity. Therefore, loss of Lamin A triggers nuclear AGO2 translocation, FAM120A mediated RNAi impairment, and upregulation of oncogenic miRNAs, facilitating cancer cell proliferation.
Cas9 interaction with the tracrRNA nexus modulates the repression of type II-A CRISPR-cas genes
Authors: Kim Hyejin , Marraffini Luciano A 
Published: July 2024

Abstract
Immune responses need to be regulated to prevent autoimmunity. CRISPR-Cas systems provide adaptive immunity in prokaryotes through the acquisition of short DNA sequences from invading viruses (bacteriophages), known as spacers. Spacers are inserted into the CRISPR locus and serve as templates for the transcription of guides used by RNA-guided nucleases to recognize complementary nucleic acids of the invaders and start the CRISPR immune response. In type II-A CRISPR systems, Cas9 uses the guide RNA to cleave target DNA sequences in the genome of infecting phages, and the tracrRNA to bind the promoter of cas genes and repress their transcription. We previously isolated a Cas9 mutant carrying the I473F substitution that increased the frequency of spacer acquisition by 2–3 orders of magnitude, leading to a fitness cost due to higher levels of autoimmunity. Here, we investigated the molecular basis underlying these findings. We found that the I473F mutation decreases the association of Cas9 to tracrRNA, limiting its repressor function, leading to high levels of expression of cas genes, which in turn increase the strength of the type II-A CRISPR-Cas immune response. We obtained similar results for a related type II-A system, and therefore our findings highlight the importance of the interaction between Cas9 and its tracrRNA cofactor in tuning the immune response to balanced levels that enable phage defense but avoid autoimmunity.