bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of sex on left ventricular remodeling in patients with aortic dissection
Authors: Diniz Roberto G.S. , Oliveira Matheus F.R.A. , Rocha Walter E.M. , Cipolli José A. , Soares Julia D. , L’Armée Victor M.F.S. , Martins Mayara P.G. , Rocha Aloísio M. , Diniz Paulo G.S. , Feitosa Audes D.M. , Lima Ricardo C. , Oliveira Pedro P.M. , Silveira-Filho Lindemberg M. , Coelho-Filho Otavio R. , Matos-Souza José R. , Petrucci Orlando , Sposito Andrei C. , Nadruz Wilson 
Published: July 2024

Aims
Patients with aortic dissection have a high prevalence of left ventricular structural alterations, including left ventricular hypertrophy (LVH), but little is known about the impact of sex on this regard. This study compared clinical, cardiac, and prognostic characteristics between men and women with aortic dissection.

Methods
We retrospectively assessed clinical and echocardiographic characteristics, and 1-year mortality in 367 aortic dissection patients (30% women; 66% with Stanford-A) who underwent echocardiography 60 days before or after the diagnosis of aortic dissection from three Brazilian centers.

Results
Men and women had similar clinical characteristics, except for higher age (59.4 ± 13.4 vs. 55.9 ± 11.6 years; P = 0.013) and use of antihypertensive classes (1.4 ± 1.3 vs. 1.1 ± 1.2; P = 0.024) and diuretics (32 vs. 19%; P = 0.004) in women compared with men. Women had a higher prevalence of LVH (78 vs. 65%; P = 0.010) and lower prevalence of normal left ventricular geometry (20 vs. 10%; P = 0.015) than men. Logistic regression analysis adjusted for confounding factors showed that women were less likely to have normal left ventricular geometry (odds ratio, 95% confidence interval = 0.42, 0.20–0.87; P = 0.019) and were more likely to have LVH (odds ratio, 95% confidence interval = 1.91, 1.11–3.27; P = 0.019). Conversely, multivariable Cox-regression analysis showed that women had a similar risk of death compared to men 1 year after aortic dissection diagnosis (hazard ratio, 95% confidence interval = 1.16, 0.77–1.75; P = 0.49).

Conclusion
In aortic dissection patients, women were typically older, had higher use of antihypertensive medications, and exhibited a greater prevalence of LVH compared with men. However, 1-year mortality after aortic dissection diagnosis did not differ between men and women.
The development of a dexamethasone challenge model for evaluating feed additives in sheep
Authors: Lea Austin J. , Trible Benjamin R. , Grum Daniel S. , Sewell Alysta D. , Sewell Jason R. , Raghavendra Rao Murali M. 
Published: July 2024

Abstract

OBJECTIVE
To develop an accessible ruminant immune challenge model for rapid in vivo assessments of feed additives.

ANIMALS
60 hair-breed ram lambs.

METHODS
Sheep were randomly assigned to 1 of 4 treatments: treatment 1, not immunosuppressed, control fed (n = 12); treatment 2, immunosuppressed, supplemented with a yeast and botanical extract (n = 18); treatment 3, immunosuppressed, supplemented with a blend of natural aluminosilicates and yeast components (n = 18); and treatment 4, immunosuppressed, control fed (n = 12). Twice-daily injections of dexamethasone (Dex; 0.1 mg/kg bodyweight, SC) were used to induce immunosuppression throughout the study (from September 25, 2020, to November 2, 2020). All sheep were immunized with keyhole limpet hemocyanin (KLH) on days 0 and 14 and injected with heat-aggregated KLH, ID, to induce a skin induration on day 15. Measurements included body weight (BW), average daily gain (ADG), CBC, and skin induration diameter.

RESULTS
Dex treatment resulted in reduced BW and ADG that was not mitigated by either feed additive. Dex reduced lymphocyte percentage, RBC count, hemoglobin, hematocrit, and skin induration diameter and increased concentrations of granulocytes and granulocyte percentage. Effects on hematocrit, hemoglobin, RBC, and skin induration diameter were mitigated with the addition of feed additives.

CLINICAL RELEVANCE
The described model is a tool to evaluate the ability of feed additives to mitigate the immunosuppressive effects of Dex.
Physiologic and behavioral effects of long-acting subcutaneous and transdermal buprenorphine in rats
Authors: Collins Elijah J. , Zhao Qianqian , Baker Tracy L. , Johnson Rebecca A. 
Published: July 2024

Abstract

OBJECTIVE
To investigate thermoregulation, thermal antinociception, food/kaolin intake, fecal output, and behavior following long-acting buprenorphine preparations in rats.

ANIMALS
8 adult male rats (Rattus norvegicus) were administered long-acting SC buprenorphine (SB; 0.65 mg/kg), transdermal buprenorphine (TB; 10 mg/kg), and controls in a randomized, cross-over design.

METHODS
Body temperature, self-injury, sedation, food/kaolin intake, fecal output, and thermal withdrawal latencies were measured 1, 4, 8, 12, 24, 48, and 72 hours posttreatment. Data analysis was performed with mixed linear models.

RESULTS
Self-injury was present between 1 and 12 hours and 4 and 12 hours following TB and SB, respectively; sedation was associated with TB at 12 to 24 hours. Withdrawal latencies were longer in both TB and SB groups than in the control group. Food intake decreased with time in all groups but was significantly lower 24 to 48 hours after TB and 24 to 72 hours after SB versus controls. Kaolin intake decreased from baseline 48 to 72 hours in the control group. Fecal output decreased from baseline 24 to 72 hours in all groups but was significantly lower than controls 24 hours following TB and 24 to 48 hours in SB. Body temperature increased from baseline at 1 hour, 1 to 12 hours, and 1 to 24 hours in the control, TB, and SB groups, respectively, and was significantly higher than the control group 1 to 72 hours following TB and 4 to 24 hours after SB. Transdermal buprenorphine and SB in normal rats produced antinociception, self-injurious behavior, hyperthermia, and decreased food/fecal output.

CLINICAL RELEVANCE
Although these buprenorphine preparations may produce antinociception, untoward effects such as hyperthermia, self-injurious behavior, and reduced food intake/fecal output may be seen.
“ХРОНІКИ НАУКОВОГО ТОВАРИСТВА ІМЕНІ ШЕВЧЕНКА” – ОСВІТНЬО-ПРОСВІТНИЦЬКИЙ ДОВІДНИК початку ХХ – першої третини ХХ ст.
Authors: Ковалишин Оксана 
Published: July 2024

У статті проаналізовано “Хроніки Наукового Товариства ім. Шевченка” як важливий довідник освітньо-просвітницького становища початку ХХ – першої третини ХХ ст. у Галичині. Досліджено бюлетень за напрямами освітньо-просвітницької діяльності Наукового товариства ім. Шевченка та взаємодії з організаціями і товариствами. Розкрито допомогу та підтримку Наукового товариства ім. Шевченка науковим курсам, університетській справі. Зосереджено увагу на меценатській діяльність Товариства для української талановитої молоді. Показаний внесок Товариства українським освітнім та просвітнім організаціям і товариствам. Виявлений вплив та взаємодію НТШ з товариством “Просвіта”.
НАУКОВО-ПЕДАГОГІЧНА СПАДЩИНА ВАСИЛЯ СУХОМЛИНСЬКОГО В ПРОФЕСІЙНІЙ ПІДГОТОВЦІ МАЙБУТНІХ УЧИТЕЛІВ У ПЕДАГОГІЧНИХ КОЛЕДЖАХ
Authors: Пустовіт Григорій 
Published: July 2024

У статті схарактеризовано головні ідеї Василя Сухомлинського, що сьогодні є визначальними у побудові змісту професійної підготовки майбутніх вчителів у педагогічних коледжах. Схарактеризовано провідні домінанти конструювання змісту професійної підготовки майбутніх вчителів у педагогічних коледжах, вибудованих на застосуванні науково-педагогічної спадщини В. Сухомлинського: підвищення якості професійної підготовки умотивованих вчителів; розвиток дослідницько-інноваційного типу мислення і власне такої діяльності; організації і здійснення їхньої самоосвіти і самовдосконалення; проведення наукової дослідницької роботи; формування педагогічної культури; розкриття теоретичних основ і прикладних засад змісту виховання.
Особливости динаміки про- і антиоксидантного балансу ран у експерименті за умов застосування для місцевого лікування запальних процесів гідрогелевих пов’язок, насичених йонами срібла й антиоксидантним лікарським засобом «Кверцетин»
Authors: Slobodian R. , Ohonovskyi R. , Melnychuk Y. 
Published: July 2024

Вступ. Запальний процес завжди супроводжується активацією пероксидного окиснення ліпідів (ПОЛ), що її спричинює тканинна гіпоксія. Це своєю чергою каталізує зміну фізіологічних показників антиоксидантної системи.
Мета. Проаналізувати динаміку про- і антиоксидантного балансу ран у експерименті за умов застосування для місцевого лікування запальних процесів гідрогелевих пов’язок, насичених йонами срібла й антиоксидантним лікарським засобом «Кверцетин».
Матеріяли й методи. Експериментальне дослідження проводили на 80 статевозрілих щурах-самцях. Тварин виводили з експерименту на 3-тю, 7-му, 10-ту, 14-ту добу. Визначали вміст малонового діальдегіду (МДА), каталазної активности (КА) й антиоксидантно-прооксидантного індексу (АПІ).
Результати. Вміст МДА на 7-му добу у другій і третій дослідних групах становив 4,11 ± 0,18 і 4,07 ± 0,21 мкмоль/л відповідно, на 10-ту добу в першій дослідній групі – 4,92 ± 0,24 мкмоль/л; у другій дослідній групі – 3,89 ± 0,13 мкмоль/л; у третій дослідній групі – 4,05 ± 0,26 мкмоль/л.
На 7-му добу в третій дослідній групі КА становила 0,51 ± 0,03 мкКат/л, на 10-ту добу в контрольній групі – 0,35 ± 0,08 мкКат/л, у першій дослідній групі – 0,35 ± 0,03, у другій дослідній групі – 0,44 ± 0,05 мкКат/л, у третій дослідній групі – 0,42 ± 0,02 мкКат/л. В усіх групах тварин показники КА наближалися до показника інтактних тварин уже на 14-ту добу.
На 7-му добу АПІ у першій дослідній групі становив 11,953 у. о., у другій і третій дослідних групах показники суттєво не відрізнялися (7,903 і 7,980 у. о), що пояснюється дією антиоксидантного лікарського засобу. На 10-ту добу поступове зниження антиоксидантних процесів фіксували у другій (8,84 у. о.) і третій (9,642 у. о.) дослідних групах.
Висновки. Аналіз отриманих результатів показав, що застосування для місцевого лікування гнійно-запальних процесів гідрогелевих пов’язок, насичених антиоксидантним лікарським засобом «Кверцетин», який пролонговано виділяється на поверхню рани, сприяє активізації антиоксидантного захисту, пригнічує процеси вільнорадикального утворення.
Big challenge in health impact of heavy metal: A case study
Authors: Tiwari Ritu , Mahalpure Gaurav Sanjay 
Published: July 2024

Herbal medicines are potential sources of therapeutic aids for human beings. WHO estimates that 80% of the world’s population depends on herbal products as their primary form of health care. Herbal plants are widely used nowadays because they have few side effects, are readily available, and are cost-effective. Herbal plants are easily contaminated by absorbing heavy metals from soil, air and water. The primary health concerns of heavy metals are Arsenic, Cadmium, Lead and Mercury. Heavy metal causes countless health-related issues, such as kidney and liver damage, skin cancer, etc. So, the estimation of heavy metals is fundamental. Modern techniques estimate heavy metals in herbal plants such as AAS, ICP-MS, ICP-AES and ICP-OES. This review article mainly contains general information about heavy metals, the health impact of heavy metals on the human body, case studies regarding heavy metal toxicity on human health and analytical techniques used to estimate heavy metals.
Three-Dimensional Determination (Morphometric Study) of Arch Perimeter and Palatal Depth in an Iraqi Sample Aged 17–25 Years with Sickle Cell Anemia: A Cross-Sectional Study
Authors: A. Abdullah Hawraa , M. A. Ahmad Haider 
Published: July 2024

Sickle cell anemia (SCA) is a hereditary disorder caused by the substitution of valine for glutamic acid in position six of globin's beta chain. Segmental arch dimensions, arch perimeter, and palatal depth comparison between SCA and control using the three-dimensional (3D) technique was the aim of this study. This cross-sectional investigation was carried out in Karbala City. The sample consisted of 200 casts (100 SCA and 100 control). Each group consisted of 50 casts upper, and 50 casts lower (25 males and 25 females). The arch perimeter was calculated using two segmented arch lengths bilaterally. Palatal depth was measured from the mesiolingual cusp tip of the upper first permanent molar to the corresponding palatal vault. The difference between the control and SCA groups was calculated using the independent t-test. Except for lower left incisal to canine distance (LLI-C), where p = 0.01 there was no significant difference in segmental arch measurements and perimeter between males in SCA and males in control. There was no significant difference in segmental arch measurements and perimeter between females in SCA and females in control. There was no significant difference in palatal depth between the control and SCA (male and female). SCA did not affect the segmental, arch perimeter, and palatal depth measurements.
Operational-amplifier-based hardware implementation of the compartmental spike model of the CSNM neuron
Authors: Бойко А.В. , Бахшиев А.В. , Корсаков А.М. 
Published: July 2024

В работе предложен вариант аппаратной реализации сегментной спайковой модели нейрона на операционных усилителях. Актуальность работы обусловлена растущей потребностью как в аппаратных реализациях нейросетевых решений в целом, так и необходимостью развития адаптивных способностей сетей, в первую очередь, к изменяющимся условиям среды. Одним из перспективных направлений представляется реализация спайковых нейронных сетей, в которых основным функциональным элементом является не нейрон, а сегмент мембраны нейрона. Аппаратная реализация таких моделей нейрона на дискретной элементной базе должна позволить облегчить экспериментальные исследования данного направления. В основу предложенного решения положена модель нейрона CSNM. В работе рассмотрены существующие подходы к аппаратной реализации моделей нейронов и выбран подход реализации на операционных усилителях. Разработаны схемы каждого сегмента реализуемой модели нейрона. Проведены тестовые эксперименты и сравнение с математической моделью, результаты которых позволили заявить, что реализация достаточно точно воспроизводит требуемые временные характеристики процессов преобразования сигналов в нейроне. Предложенная реализация позволяет гибко менять структуру дендритного и синаптического аппарата нейрона и удобно интерпретировать сигналы для сопоставления с математической моделью. Недостатком предложенного решения является низкая энергоэффективность, однако для исследовательских целей этот аспект на данном этапе не является критичным.
ANALISIS TIPE IKLIM BERDASARKAN CURAH HUJAN PADA BEBERAPA KECAMATAN DI KABUPATEN LOMBOK BARAT
Authors: Anas Tasiyah Lindri , Sutriono Raden , Silawibawa I Putu 
Published: July 2024

Permasalahan perubahan iklim dipulau Lombok khususnya di Kabupaten Lombok Barat, hal ini menjadi faktor utama dalam melaksanakan kegiatan produksi pertanian di wilayah Kabupaten Lombok Barat. Salah satu upaya yang harus dilakukan dengan analisis tipe iklim dengan menggunakan metode Oldeman agar dapat mengetahui kebutuhan air tanaman serta curah hujan pada wilayah tersebut. Tujuan dari penelitian ini yaitu, untuk mengetahui mengetahui tipe iklim di beberapa Kecamatan di Lombok Barat berdasarkan klasifikasi iklim menurut Oldeman. Metode yang digunakan dalam peneltian ini adalah metode deskriptif, yang dimulai dengan pengumpulan data dari badan meteorologi, klimatologi dan geofisika., menganalisis data dan menginterpetasi data. Analisis tipe menurut Oldeman pada dasarnya menentukan jumlah bulan basah, bulan kering dan bulan lembab yang dimana jumlah bulan basah > 200 mm, bulan kering < 100 mm dan bulan lembab 100-200 mm. Hasil yang diperoleh dari penentuan tipe iklim pada beberapa Kecamatan yaitu pada Kecamatan Kediri bertipe iklim C3, pada Kecamatan Narmada D3, pada Kecamatan Lembar D3 dan pada Kecamatan Gerung bertipe iklim E3.
MENENTUKAN DAN MENGUKUR STANDAR MUTU PENDIDIKAN (STUDI DI SEKOLAH DASAR NEGERI KOTA GORONTALO)
Authors: Syafar Djunawir , Sidik Firman , Arif Kurniawan Muchamad 
Published: July 2024

Menentukan dan mengukur standar mutu adalah aspek penting dalam pendidikan karena akan menentukan tujuan dan kualitas dari suatu lembaga pendidikan. Penelitian ini membahas bagaimana cara menentukan dan mengukur standar mutu pendidikan di Sekolah Dasar Negeri 41 Kota Gorontalo. Sekolah tersebut dijadikan lokus penelitian, karena beberapa faktor. Pertama, sekolah tersebut telah terakreditasi (A) dari Badan Akreditasi Nasional Pendidikan. Kedua, sekolah tersebut adalah sekolah percontohan di kota Gorontalo dengan manajemen sekolah yang unggul. Ketiga, sekolah tersebut pernah dijadikan Rintisan Sekolah Bertaraf Internasional (RSBI) di kota Gorontalo. Penelitian ini adalah studi kualitatif. Pengumpulan data dalam penelitian ini dengan dua cara: wawancara dan dokumentasi. Hasil penelitian ini menunjukkan: Pertama, dalam menentukan dan mengukur standar mutu pendidikan di Sekolah Dasar Negeri 41 Kota Gorontalo mengacu pada delapan Standar Nasional Pendidikan, yakni: (1) standar isi, (2) standar proses, (3) standar kompetensi lulusan, (4) standar pendidik dan tenaga kependidikan, (5) standar sarana dan prasarana, (6) standar pengelolaan, (7) standar pembiayaan, (8) standar penilaian pendidikan. Kedua, melalui standar internal sekolah yaitu: input, proses, output, dan outcome. Kedua pendekatan tersebut digunakan untuk menyesuaikan dengan standar nasional pendidikan dan kebutuhan internal sekolah. Melalui dua pendekatan tersebut, Sekolah Dasar Negeri 41 Kota Gorontalo menjadi sekolah percontohan di kota Gorontalo dengan manajemen sekolah yang unggul.
Pengaruh Disiplin Kerja, Motivasi Kerja Dan Lingkungan Kerja Terhadap Kinerja Karyawan Dinas Parekrafbudpora Gresik
Authors: Wijayanto Kevin Julian 
Published: July 2024

Abstract

The background of this research is the performance of employees of the Gresik Office of Tourism and Culture who have not reached the agency's target. The purpose of this study is to analyze whether there is a partial influence of discipline, motivation, and work environment on performance. The method in this study uses quantitative methods. The data analysis technique in this study used multiple linear regression analysis. The number of samples used in this study were 71 respondents. The analysis technique uses instrument testing, classical assumption test, and hypothesis testing. For test aids using the Statistical Package for the Social Sciences (SPSS). The results of this study indicate that discipline has a significant effect on employee performance, work motivation has a significant effect on employee performance, and work environment has a significant effect on employee performance.
Spotlight on festival travellers: Profiles, Motivations, and Experiences of Dieng Culture Festival Travellers, Indonesia
Authors: Fajriaty Muchlis Nur Farah , Rahayu Mia , Renold Renold , Ridwan Masri 
Published: July 2024

The study found a change in the motivation of visitors to the festival. This study aims to identify visitors' memorable experiences related to tourist attractions at the Dieng Culture Festival, held from 2020 to 2022. The research was conducted using a quantitative-interpretative approach, with research instruments designed to determine visitors' profiles, purposes, and experiences. The sample size consisted of 398 respondents and 5 key informants. The research methodology involved data collection through online surveys and in-depth interviews with key informants. The research findings are presented below. Based on the respondents' characteristics, it can be inferred that most visitors to the Dieng Culture Festival are over 20 years old. The primary purpose of their visit was to experience and participate in the jazz music performances held above the clouds, as indicated by 271 respondents (67.9%). The most prominent attendees are private employees, with 143 respondents (38.5%), followed by students. Notably, 321 respondents (80.5%) learned about the Dieng Culture Festival online. The gender of visitors is dominated by women, with 177 (44.4%) male respondents, while the number of female respondents is 222 (55.6%). Jazz music above the clouds is a memorable programme because it represents visitors' needs. The commodification of the Ruwatan procession of cutting dreadlocks is needed to increase the impression for visitors and strengthen the image of local cultural recognition.
Sistem Pendukung Keputusan Penerimaan Karyawan dengan Metode Simple Additive Weighting Berbasis Website
Authors: Nabilla Aulia Nisa  , Winarto  
Published: July 2024

Within the scope of an organization, human resources are needed. Human resources are used as organizational assets to improve the performance of their organizations, one of which is maintaining their company assets to continue to reform, namely by finding or recruiting new employees according to the needs of the company. Along with the times and industry competition, companies are expected to use technology to significantly increase efficiency and effectiveness so as to compete with other companies. One of the uses of technology to help the company's activities to be efficient and effective is the process of recruiting new employees by using online website-based technology information systems. The use of website-based information technology information systems is modeled in the model of multiple attribute decision making (MADM) which is to look for a number of alternatives to certain criteria and choose based on the best rankings. In MADM modeling there are several methods that are used as calculations, namely, Simple Additive Weighting Method (SAW), Weighted Product (WP), ELECTRE, Technique for Order Preference by Similarity to Ideal Solution (TOPSIS), and Analytic Hierarchy Process (AHP). The decision support system in this study uses the Simple Additive Weighting Method (SAW)method. In this case, prospective new employees will be compared to each other in each assessment of criteria and sub-criteria and weight values that have been determined by the company. The results of this system that has been designed result in a decision support system to determine who the prospective employees who qualify in the administrative stage
Intervention of Local Resource-Based MSME Human Resource’s Competency Development
Authors: Suyatno Suyatno , Suryani Dewi Amanatun 
Published: July 2024

This research aims to obtain a comprehensive and complete picture of local potential-based MSME HR competency development interventions in improving the community economy in Girikerto Village. The findings of this research are that the Girikerto community has various local resources that are developed and utilized to become more economically valuable and competitive. Interventions for developing MSME HR competencies have been carried out by relevant stakeholders consisting of government, academics, supporting institutions, and funding institutions in the form of policies, training programs, mentoring, development, and facilitation in a coordinative and collaborative manner. This research focuses on interventions to develop MSME HR competencies, while previous studies have focused more on the importance of competencies, types of competencies, and the role of HR competencies in MSMEs. This research uses qualitative methods, primary data collection was carried out through observation and interviews with the MSME's Actor in Girekerto, while secondary data was obtained from documents, articles, and social media. The findings from this research have implications for the Village Government and related institutions in preparing intervention strategies for developing MSME HR competencies based on local potential. The government must intervene in collaboration and coordination with related institutions in formulating policies, programs, and facilitation for MSME groups based on available resources. Policies, programs, and facilitation must be carried out continuously and coordinatedly.