bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serodiagnosis of nasal myasis in camels (Camelus dromedaries) in Egypt using third larval instar affinity-purified glycoprotein
Authors: Aboelsoued Dina , Toaleb Nagwa I. , Mohamed Amany M. , Abdel Megeed Kadria N. , Hekal Sahar Hussein Abdalla 
Published: July 2024

AbstractThe larvae of Cephalopina titillator cause nasopharyngeal myiasis in camels, which parasitize the living tissues of the nasal and paranasal sinuses, pharynx, and larynx. C. titillator infestation adversely affects camel health, meat, and milk production, and can even cause death. In our study, to improve the immunodiagnosis of camel nasal myiasis, a sensitive and specific enzyme-linked immunosorbent assay (ELISA) was developed and evaluated using the Concanavalin-A (Con-A) affinity purification for the C. titillator-N-acetylglucosamine (Ct-GlucNAc) glycoprotein fraction from third larval instars as an antigen for detecting C. titillator antibodies. Crude antigens were prepared from larval instars of C. titillator and evaluated by indirect ELISA. The third C. titillator larval antigen (L3Ct) had the highest protein content (P < 0.001) and the best diagnostic value; chi-square = 235 (P < 0.001). Four glycoprotein fractions were purified separately from the L3Ct antigen by Con-A purification and evaluated. The Ct-GlucNAc glycoprotein fraction was the fraction of choice with the highest diagnostic accuracy (P < 0.05). Using Ct-GlucNAc as a coating antigen, indirect ELISA showed a 99.3% sensitivity for positive results in camel myiasis samples and 100% specificity for negative results in healthy camel samples. The diagnostic accuracy was 99.7%, and no cross reactivity was detected for other parasitic diseases. The indirect ELISA results were confirmed by the western immunoblotting which was characterized by comparing sera from naturally infested dromedary camels with C. titillator, sera from healthy camels and sera from camels with other parasitic infections (Echinococcus granulosus, Fasciola gigantica, Hard ticks; Hyalomma dromedarii, Trichostronglid sp., Eimeria spp., and Cryptosporidium sp.). Immunoreactive antigenic bands of 63, 50, 30 and 18 kDa were predominantly detected in sera from camels with nasopharyngeal myiasis and didn’t react with healthy and camel’s sera from other parasitic infections. However, seven immunoreactive bands appeared at 120, 70, 63, 48, 35, 29, and 19 kDa in the crude L3Ct antigen. In addition, a positive rate of C. titillator immunodiagnosis was detected by indirect ELISA (48.6%, chi-square = 483, P < 0.001), which was significantly greater than that of postmortem diagnosis (31%). In conclusion, the current study introduces a new diagnostic immunoaffinity glycoprotein fraction of C. titillator 3rd larval instar-based ELISA as a highly accurate, simple and fast method to detect specific antibodies of nasal myiasis in camels.
Nuclear-Based Labeling of Cellular Immunotherapies: A Simple Protocol for Preclinical Use
Authors: Volpe Alessia , Lyashchenko Serge K. , Ponomarev Vladimir 
Published: July 2024

AbstractLabeling and tracking existing and emerging cell-based immunotherapies using nuclear imaging is widely used to guide the preclinical phases of development and testing of existing and new emerging off-the-shelf cell-based immunotherapies. In fact, advancing our knowledge about their mechanism of action and limitations could provide preclinical support and justification for moving towards clinical experimentation of newly generated products and expedite their approval by the Food and Drug Administration (FDA).Here we provide the reader with a ready to use protocol describing the labeling methodologies and practical procedures to render different candidate cell therapies in vivo traceable by nuclear-based imaging. The protocol includes sufficient practical details to aid researchers at all career stages and from different fields in familiarizing with the described concepts and incorporating them into their work.
Rolling table centrifuge modelling of partially saturated granular material to inform on instability during solid bulk cargo transport
Authors: Kwa Katherine , Gourvenec Susan , Evans Tim , Koseki Junichi , Kishimoto Kenichi 
Published: July 2024

AbstractThe response of partially saturated granular cargoes during maritime transportation has resulted in the capsize and sinking of 27 bulk carriers at sea and the loss over 90 seafarers’ lives in the last decade. The partially saturated granular material response to energy imparted during cargo loading, ship engine vibrations and vessel rolling motions from sea states causes a change in state of the granular cargo, which can lead to vessel instability and ultimately capsize. However, the mechanisms driving the response of partially saturated granular cargos within a bulk carrier hold are not well understood. This paper presents results from an experimental study of rolling table centrifuge model tests on a partially saturated silica sand to contribute to improved understanding of the response of granular cargoes during maritime transport. Observed settlement, pore pressure, moisture content and density changes during and/or following a sequence of large amplitude rolling motions are presented. The results indicate that for the conditions considered, a progressive upwards migration of pore water during rolling led to creation of a free surface of water above the granular sample that was left in a denser, lower moisture content sample compared to its initial state. Sloshing of free water on top of even a competent cargo during rolling motions of the ship can contribute to loss of ship stability and ultimately capsize.
Acquisition of peak bone mass in a Norwegian youth cohort: longitudinal findings from the Fit Futures study 2010–2022
Authors: Sagelv Edvard H. , Emaus Nina , Evensen Elin , Christoffersen Tore , Dennison Elaine , Furberg Anne-Sofie , Grimnes Guri , Johansson Jonas , Nielsen Christopher Sivert , Nilsen Ole Andreas , Winther Anne 
Published: July 2024

Abstract

Summary

In a Norwegian youth cohort followed from adolescence to young adulthood, bone mineral density (BMD) levels declined at the femoral neck and total hip from 16 to 27 years but continued to increase at the total body indicating a site-specific attainment of peak bone mass.

Purpose
To examine longitudinal trends in bone mineral density (BMD) levels in Norwegian adolescents into young adulthood.

Method
In a prospective cohort design, we followed 980 adolescents (473 (48%) females) aged 16–19 years into adulthood (age of 26–29) on three occasions: 2010–2011 (Fit Futures 1 (FF1)), 2012–2013 (FF2), and 2021–2022 (FF3), measuring BMD (g/cm2) at the femoral neck, total hip, and total body with dual x-ray absorptiometry (DXA). We used linear mixed models to examine longitudinal BMD changes from FF1 to FF3.

Results
From the median age of 16 years (FF1), femoral neck BMD (mean g/cm2 (95% CI)) slightly increased in females from 1.070 (1.059–1.082) to 1.076 (1.065–1.088, p = 0.015) at the median age of 18 years (FF2) but declined to 1.041 (1.029–1.053, p < 0.001) at the median age of 27 years (FF3). Similar patterns were observed in males: 16 years, 1.104 (1.091–1.116); 27 years, 1.063 (1.050–1.077, p < 0.001); and for the total hip in both sexes (both p < 0.001). Total body BMD increased from age 16 to 27 years in both sexes (females: 16 years, 1.141 (1.133–1.148); 27 years, 1.204 (1.196–1.212), p < 0.001; males: 16 years, 1.179 (1.170–1.188); 27 years, 1.310 (1.296–1.315), p < 0.001).

Conclusion
BMD levels increased from 16 to 18 years at the femoral and total hip sites in young Norwegian females and males, and a small decline was observed at the femoral sites when the participants were followed up to 27 years. Total body BMD continued to increase from adolescence to young adulthood.
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial
Authors: Zhao Jun , Zheng Hui , Wang Xin , Wang Xuefei , Shi Yunzhou , Xie Chaorong , Tao Qingfeng , Li Da , Sun Jingwen , Tian Junjian , Gao Junxia , Liu Huimin , Shi Suhua , Ni Jinxia , Xue Rongdan , Hu Hui , Chen Min , Yu Shuguang , Li Zhigang 
Published: July 2024

AbstractPrevious studies have confirmed that acupuncture for irritable bowel syndrome (IBS) provided an additional benefit over usual care alone. Therefore, we performed a multicenter, randomized, sham-controlled trial to assess the efficacy and safety of acupuncture versus sham acupuncture for refractory IBS in patients in the context of conventional treatments. Patients in the acupuncture and sham acupuncture groups received real or sham acupuncture treatment in 3 sessions per week for a total of 12 sessions. The primary outcome was a change in the IBS–Symptom Severity Scale (IBS-SSS) score from baseline to week 4. A total of 521 participants were screened, and 170 patients (85 patients per group) were enrolled and included in the intention-to-treat analysis. Baseline characteristics were comparable across the two groups. From baseline to 4 weeks, the IBS-SSS total score decreased by 140.0 (95% CI: 126.0 to 153.9) in the acupuncture group and 64.4 (95% CI: 50.4 to 78.3) in the sham acupuncture group. The between-group difference was 75.6 (95% CI: 55.8 to 95.4). Acupuncture efficacy was maintained during the 4-week follow-up period. There were no serious adverse events. In conclusion, acupuncture provided benefits when combined with treatment as usual, providing more options for the treatment of refractory IBS.
SEOM-GG clinical guidelines for the management of germ-cell testicular cancer (2023)
Authors: Arranz Arija José Angel , del Muro Xavier García , Caro Raquel Luque , Méndez-Vidal María José , Pérez-Valderrama Begoña , Aparicio Jorge , Climent Durán Miguel Ángel , Caballero Díaz Cristina , Durán Ignacio , González-Billalabeitia Enrique 
Published: July 2024

AbstractTesticular germ cell tumors are the most common tumors in adolescent and young men. They are curable malignancies that should be treated with curative intent, minimizing acute and long-term side effects. Inguinal orchiectomy is the main diagnostic procedure, and is also curative for most localized tumors, while patients with unfavorable risk factors for recurrence, or those who are unable or unwilling to undergo close follow-up, may require adjuvant treatment. Patients with persistent markers after orchiectomy or advanced disease at diagnosis should be staged and classified according to the IGCCCG prognostic classification. BEP is the most recommended chemotherapy, but other schedules such as EP or VIP may be used to avoid bleomycin in some patients. Efforts should be made to avoid unnecessary delays and dose reductions wherever possible. Insufficient marker decline after each cycle is associated with poor prognosis. Management of residual masses after chemotherapy differs between patients with seminoma and non-seminoma tumors. Patients at high risk of relapse, those with refractory tumors, or those who relapse after chemotherapy should be managed by multidisciplinary teams in experienced centers. Salvage treatment for these patients includes conventional-dose chemotherapy (TIP) and/or high-dose chemotherapy, although the best regimen and strategy for each subgroup of patients is not yet well established. In late recurrences, early complete surgical resection should be performed when feasible. Given the high cure rate of TGCT, oncologists should work with patients to prevent and identify potential long-term side effects of the treatment. The above recommendations also apply to extragonadal retroperitoneal and mediastinal tumors.
The Silver Lining in the Clouds: A Commentary on Stephen Turner’s “Mad Hazard, a Life in Social Theory”
Authors: Riccioni Ilaria 
Published: July 2024

AbstractWhile it is true that to do social theory is to become an observer of life and its development from an outside perspective, it is also true that, in Weberian terms, ethical neutrality cannot disregard experience itself and values as necessary tools for making sense of reality. Indeed, according to Weber, there is no research or social theory without being aware of one’s own values and experience. In this sense, Stephen Turner’s autobiographical book Mad Hazard is great evidence that a scholar’s understanding of social theory is inevitably enriched by an understanding of the life events to which it is related, whereby life experience enhances the ability to grasp the attempt at theorizing in intellectual life, offering the perspective of how that theory observes social reality. Intellectual life and everyday life are necessarily connected. One cannot be fully grasped without the other, but in Weberian terms the autobiography of Stephen Turner can represent precisely the big frame, or statement of values, through which all experiences, bad and good, become the little pieces of the grand picture of this interweaving of practical life and intellectual life, always in continuous reference and making sense from one another.
Contested Understandings of Violence: Refiguring Modern and Postmodern Perspectives
Authors: Coenen Ekkehard 
Published: July 2024

AbstractThere are numerous conceptions of violence today, such as physical, psychological, emotional, structural, and epistemic. The question of which social phenomena are to be described as violence is itself a matter of furious dispute. In social theory, there is a widespread tendency to distinguish between ‘modern’ and ‘postmodern’ conceptions of violence. In this scheme, modern violence is primarily physical, while postmodern violence takes places across a broad spectrum of forms. The paper questions this binary. The co-occurrence and conflict between these forms of violence leads to a third form, which I call refigured violence. The refiguration of violence can be observed in three developments, which are mediatisation, polycontexturalisation, and translocalisation. I provide one illustration of these considerations with the example of so-called shock sites on the internet. In so doing, I emphasise that the sociology of knowledge can provide a valuable perspective for making sense of contemporary discourses about violence in all their complexity.
Quantitative Assessment and Validation of Groundwater Pollution Risk in Southwest Karst Area
Authors: Liu Mei , Huan Huan , Li Haixiang , Liu Weijiang , Li Juan , Zhao Xiaobing , Zhou Aixia , Xie Xianjun 
Published: July 2024

Abstract
Groundwater pollution risk assessment is a useful tool for groundwater pollution prevention and control. However, it is difficult to accurately quantify groundwater flow and contaminant fluxes in karst areas and different types of karst areas have different hydrogeological characteristics. Therefore, the assessment of groundwater pollution risk in karst areas must use different assessment indicator systems. This study developed a new methodology that modified the vulnerability assessment model PLEIK, determined pollutant fluxes considering hydrogeological conditions, and revised parameter weights using the random forest method. The resulting PLEIKD-RF model was used to assess the risk of groundwater contamination in the southwestern karst region and its validity was verified. The results showed that the groundwater pollution risk in the region was low, with 65.64% of the low and relatively low risk areas located in the middle and high mountainous regions. 11.81% of the high and relatively high risk areas were sporadically located in the western and central regions, which were mainly controlled by the distribution of the pollution sources and the karst development. The accuracy of the results of groundwater pollution risk assessment in the study area was 71.87% as verified by the horizontal difference method. The results of the sensitivity analysis indicated that accurate, detailed, and representative data on the protective layer, surface water-groundwater interactions, and pollution source loads would improve the accuracy of groundwater pollution risk zoning. This assessment method provided a reference for similar assessments and the results provide a basis for the protection and management of groundwater resources in the region.
Preoperative intra-aortic balloon pump in patients with ST-elevation myocardial infarction undergoing urgent cardiac bypass surgery
Authors: Hemradj Veemal V. , Spanjersberg Alexander J. , Buitenhuis Marit , Markou Thanasie , Hermanides Rik S. , Dambrink Jan-Henk , Gosselink Marcel , Roolvink Vincent , van Leeuwen Maarten , Ottervanger Jan Paul 
Published: July 2024

Abstract
Background
In patients with ST-elevation myocardial infarction (STEMI), either with or without cardiogenic shock, mechanical circulatory support with an intra-aortic balloon pump (IABP) is not associated with lower mortality. However, in STEMI patients undergoing urgent coronary artery bypass grafting (CABG), preoperative insertion of an IABP has been suggested to reduce mortality. In this study, the effect of preoperative IABP use on mortality in STEMI patients undergoing urgent CABG was investigated.

Methods
All consecutive STEMI patients undergoing urgent CABG in a single centre between 2000 and 2018 were studied. The primary outcome, 30-day mortality, was compared between patients with and without a preoperative IABP. Subgroup analysis and multivariable analysis using a propensity score and inverse probability treatment weighting were performed to adjust for potential confounders.

Results
A total of 246 patients were included, of whom 171 (69.5%) received a preoperative IABP (pIABP group) and 75 (30.5%) did not (non-pIABP group). In the pIABP group, more patients suffered from cardiogenic shock, persistent ischaemia and reduced left ventricular function. Unadjusted 30-day mortality was comparable between the pIABP and the non-pIABP group (13.3% vs 12.3%, p = 0.82). However, after correction for confounders and inverse probability treatment weighting preoperative IABP was associated with reduced 30-day mortality (relative risk 0.52, 95% confidence interval 0.30–0.88).

Conclusion
In patients with STEMI undergoing urgent CABG, preoperative insertion of an IABP is associated with reduced mortality.
The Role of Physical Exercise as a Therapeutic Tool to Improve Lipedema: A Consensus Statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF)
Authors: Annunziata Giuseppe , Paoli Antonio , Manzi Vincenzo , Camajani Elisabetta , Laterza Francesco , Verde Ludovica , Capó Xavier , Padua Elvira , Bianco Antonino , Carraro Attilio , Di Baldassarre Angela , Guidetti Laura , Marcora Samuele Maria , Orrù Stefania , Tessitore Antonio , Di Mitri Roberto , Auletta Lucia , Piantadosi Angela , Bellisi Mario , Palmeri Edmondo , Savastano Silvia , Colao Annamaria , Caprio Massimiliano , Muscogiuri Giovanna , Barrea Luigi 
Published: July 2024

Abstract
Purpose of Review
This consensus statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF) provides the official view on the role of exercise as a non-pharmacological approach in lipedema. In detail, this consensus statement SISMeS - SIF aims to provide a comprehensive overview of lipedema, focusing, in particular, on the role played by physical exercise (PE) in the management of its clinical features.

Recent Findings
Lipedema is a chronic disease characterized by abnormal fat accumulation. It is often misdiagnosed as obesity, despite presenting distinct pathological mechanisms. Indeed, recent evidence has reported differences in adipose tissue histology, metabolomic profiles, and gene polymorphisms associated with this condition, adding new pieces to the complex puzzle of lipedema pathophysiology. Although by definition lipedema is a condition resistant to diet and PE, the latter emerges for its key role in the management of lipedema, contributing to multiple benefits, including improvements in mitochondrial function, lymphatic drainage, and reduction of inflammation.

Summary
Various types of exercise, such as aquatic exercises and strength training, have been shown to alleviate symptoms and improve the quality of life of patients with lipedema. However, standardized guidelines for PE prescription and long-term management of patients with lipedema are lacking, highlighting the need for recommendations and further research in this area in order to optimise therapeutic strategies.
Of Yeasts and Humans
Authors: Kováč Ladislav 
Published: July 2024

AbstractHumankind, the biological species Homo sapiens, lives today in a very different world from the one for which it was evolutionarily selected in the geological epoch Pleistocene (2.6 million to twelve thousand years BC). The Anthropocene, as the epoch we live now has been called, is characterized by increasing tension between human nature and technological civilization, and humans live in an atmosphere of uncertainty, insecurity, and threat. By “naturalizing” the human condition, cognitive biology offers the only painless alternative to the many scenarios that depict the extinction of Homo sapiens as a consequence of violent conflicts and unimaginable suffering.
Self-supervised multi-object tracking based on metric learning
Authors: Feng Xin , Liu Yan , Yang Hanzhi , Jiao Xiaoning , Liu Zhi 
Published: July 2024

AbstractThe current paradigm of joint detection and tracking still requires a large amount of instance-level trajectory annotation, which incurs high annotation costs. Moreover, treating embedding training as a classification problem would lead to difficulties in model fitting. In this paper, we propose a new self-supervised multi-object tracking based on the real-time joint detection and embedding (JDE) framework, which we termed as self-supervised multi-object tracking (SS-MOT). In SS-MOT, the short-term temporal correlations between objects within and across adjacent video frames are both considered as self-supervised constraints, where the distances between different objects are enlarged while the distances between same object of adjacent frames are brought closer. In addition, short trajectories are formed by matching pairs of adjacent frames using a matching algorithm, and these matched pairs are treated as positive samples. The distances between positive samples are then minimized for futher the feature representation of the same object. Therefore, our method can be trained on videos without instance-level annotations. We apply our approach to state-of-the-art JDE models, such as FairMOT, Cstrack, and SiamMOT, and achieve comparable results to these supevised methods on the widely used MOT17 and MOT20 challenges.
COVID-19 Led Return to Kerala: A Comparative Analysis of Return Emigrants
Authors: Rajan S. Irudaya , Pattath Balasubramanyam 
Published: July 2024

AbstractThis article concerns emigrants who returned to Kerala between May and December 2020 in the midst of the COVID-19 pandemic. We study and document the experiences of 1985 return emigrants (REM) through a quantitative survey conducted via Computer-Assisted Telephonic Interviews. The study utilises a comparative classificatory framework that categorises return emigrants into three groups: normal REM, distressed REM, and REM who returned to re-emigrate. While the REM have been a demographically, politically, and economically significant component of Kerala’s population, the COVID-19 REM represent a unique case in history that has the potential to not only affect the economy, society, and psyche of Kerala for many years to come, but to also provide valuable insights into the future of global labor migration governance.