bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Light‐Induced Expandable Photoresponsive Polymeric Nanoparticles for Triggered Release
Authors: Wang Zhen , Wang Peng , Tang XinJing 
Published: July 2013

AbstractHigh stability of drug‐delivery nanocarriers during blood circulation is critical for effective drug delivery and low systematic toxicity, although destabilization of these nanocarriers is required for efficient release when they reach target sites. To develop efficient polymeric nanocarriers, we intended to synthesize and characterize a group of cross‐linked, light‐induced, expandable, polymeric nanoparticles through miniemulsion polymerization. These synthesized nanoparticles were stable in aqueous solutions, although light irradiation led to particle uncaging and further particle expansion up to 315‐fold in volume. This resulted in the efficient release of the encapsulated contents in aqueous solutions and three cell lines (HeLa, RAW264.7, and MCF‐7). Selective triggered release was also successfully achieved with spatial resolution in cell monolayers. In addition, curcumin encapsulation and photoregulation of its release were realized. Further cell viability of encapsulated curcumin was successfully achieved with light activation.
Framework for distributed autonomic self‐healing in fixed IPv6 networks
Authors: Tcholtchev Nikolay , Schieferdecker Ina 
Published: July 2013

SUMMARYA main requirement for the Future Internet is to enable self‐management behaviors facilitating the network to adapt to changing conditions and self‐heal in the face of erroneous states. On the basis of Autonomic Fault‐Management principles, this paper proposes a framework consisting of a set of components operating inside the network elements and allowing the devices to collaboratively realize self‐healing. In that context, Autonomic Fault‐Management is intuitively constituted by the detection of the presence of faulty conditions, followed in turn by the self‐diagnosis and identification of the corresponding root causes, and completed consequently by the removal of the identified root causes and their effects. The proposed framework implements a distributed control loop that interacts with the network operations personnel in case the current erroneous state is not resolvable by means of Autonomic Fault‐Management. We argue that there are a number of mutual benefits between our proposed framework and the IPv6 protocol suite. This is demonstrated by a case study that illustrates these benefits and shows how the capabilities of IPv6 can be enhanced through the self‐healing mechanisms of the proposed framework. Finally, the prototype implementation used for the case study is analyzed in terms of scalability and overhead produced in the network nodes. Copyright © 2013 John Wiley & Sons, Ltd.
Efficacy of alogliptin, a dipeptidyl peptidase‐4 inhibitor, on glucose parameters, the activity of the advanced glycation end product (AGE) – receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes
Authors: Sakata Koji , Hayakawa Manabu , Yano Yuichiro , Tamaki Noboru , Yokota Naoto , Eto Takuma , Watanabe Reiko , Hirayama Naoteru , Matsuo Takeshi , Kuroki Kazuo , Sagara Seiji , Mishima Osamu , Koga Masahiro , Nagata Naoto , Nishino Yuri , Kitamura Kazuo , Kario Kazuomi , Takeuchi Masayoshi , Yamagishi Sho‐ichi 
Published: July 2013

AbstractBackgroundTo examine the effects of alogliptin, a dipeptidyl peptidase‐4 inhibitor, on glucose parameters, the advanced glycation end product (AGE)‐receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes patients.MethodsSixty‐one patients whose HbAlc ≥ 6.1% (mean age 64.7 years; 67% men; mean HbAlc 7.4%; 57% were pharmacologically treated) underwent blood and urine sampling and analysis before and after 12 weeks of treatment with alogliptin (25 mg once daily).ResultsAlogliptin treatment significantly reduced fasting glucose (160.3 mg/dL at baseline versus 138.0 mg/dL at 12 weeks), glycoalbumin (21.1% at baseline versus 18.9% at 12 weeks), HbAlc (7.4% at baseline versus 6.9% at 12 weeks), circulating soluble form of RAGE concentrations (847.3 pg/mL at baseline versus 791.4 pg/mL at 12 weeks) and urine albumin to creatinine ratio (31.6 mg/g Cr at baseline versus 26.5 mg/g Cr at 12 weeks), whereas 1,5‐anhydroglucitol concentrations were significantly increased (7.5 µg/mL at baseline versus 11.6 µg/mL at 12 weeks; all P < 0.05). Circulating AGEs concentrations were reduced only in patients with baseline AGEs ≥7 U/mL (n = 33, from 8.2 U/mL to 7.2U /mL; p < 0.01) after alogliptin treatment. The treatment‐induced change of soluble form of sRAGE concentrations was associated with changes of 1,5‐anhydroglucitol and HbAlc concentrations (rho = −0.32 and 0.29, respectively). Meanwhile, the treatment‐induced change of urine albumin to creatinine ratio was associated with a change in the fasting glucose concentration (rho = 0.25; all p < 0.05). During the intervention, alogliptin treatment was well tolerated without any hypoglycemia or side effects.ConclusionAlogliptin treatment improved the AGE–RAGE axis and reduced albuminuria in Japanese type 2 diabetes patients. Copyright © 2013 John Wiley & Sons, Ltd.
RNA‐binding protein Vg1RBP regulates terminal arbor formation but not long‐range axon navigation in the developing visual system
Authors: Kalous Adrianna , Stake James I. , Yisraeli Joel K. , Holt Christine E. 
Published: July 2013

ABSTRACTLocal synthesis of β‐actin is required for attractive turning responses to guidance cues of growth cones in vitro but its functional role in axon guidance in vivo is poorly understood. The transport and translation of β‐actin mRNA is regulated by the RNA‐binding protein, Vg1RBP (zipcode‐binding protein‐1). To examine whether Vg1RBP plays a role in axon navigation in vivo, we disrupted Vg1RBP function in embryonic Xenopus laevis retinal ganglion cells by expressing a dominant‐negative Vg1RBP and by antisense morpholino knockdown. We found that attractive turning to a netrin‐1 gradient in vitro was abolished in Vg1RBP‐deficient axons but, surprisingly, the long‐range navigation from the retina to the optic tectum was unaffected. Within the tectum, however, the branching and complexity of axon terminals were significantly reduced. High‐resolution time‐lapse imaging of axon terminals in vivo revealed that Vg1RBP‐GFP‐positive granules accumulate locally in the axon shaft immediately preceding the emergence a filopodial‐like protrusion. Comparative analysis of branch dynamics showed that Vg1RBP‐deficient axons extend far fewer filopodial‐like protrusions than control axons and indicate that Vg1RBP promotes filopodial formation, an essential step in branch initiation. Our findings show that Vg1RBP is required for terminal arborization but not long‐range axon navigation and suggest that Vg1RBP‐regulated mRNA translation promotes synaptic complexity. © 2013 Wiley Periodicals, Inc. Develop Neurobiol 74: 303–318, 2014
Utilization of Surplus Electric Power of Photovoltaic Systems by Heat Pump Water Heaters: A Planning Method and Its Effect in an Autonomous Demand Area Power System
Authors: Hatta Hiroyuki , Kobayashi Hiromu 
Published: July 2013

SummaryLarge‐capacity photovoltaic (PV) systems will be installed in future power systems. According to Japan's energy outlook, the target capacity of PV systems for 2030 is about 50 GW. When large‐volume PV systems are installed in a power system, the reverse power flow from PV systems may cause a surplus of electric power. To utilize the surplus electric power without reduction of PV power generation, the operation of customer equipment such as heat pump water heaters (HPWH) according to PV power generation is expected to be one of the solutions. In this paper, a method of cooperative control of customer equipment with PV power generation is proposed, and the effectiveness of the proposed control is evaluated by simulation analyses.
Structure of the Chloride‐ and Bromide‐Intercalated Layered Double Hydroxides of Li and Al – Interplay of Coulombic and Hydrogen‐Bonding Interactions in the Interlayer Gallery
Authors: Nagendran Supreeth , Kamath P. Vishnu 
Published: July 2013

AbstractRietveld refinement of the structures of the [LixAl(OH)3]Xx·yH2O (X = Br, Cl; y ≈ 1/2, 2/3) layered double hydroxides (LDHs) shows that the halide ion occupies two distinct positions in each phase. One position (2a), promoted by Coulombic attraction, is proximal to the Li+ ion, which is the seat of the positive charge in the metal hydroxide layer. The other position (6h) is within a close hydrogen‐bonding distance from the hydroxy group of the metal hydroxide layer as well as the intercalated water molecule. The LDH with intercalated Br– ions crystallizes in two different structures, one of which is isostructural with the Cl– analogue. In the other structure obtained at a higher relative humidity (≥76 %; y ≈ 2/3), the Br– ion occupies a site proximal to the Al3+ ion (2b), and intercalated water molecules are proximal to the Li+ ion. In this structure, the hydration of the Li+ ion in a distant coordination shell overcomes Coulombic interactions with Br– ions. On partial dehydration (ambient humidity 29 %; y ≈ 1/2), this Br– ion reversibly reverts back to the site (2a) proximal to the Li+ ion, which results in a humidity‐induced structure change without any variation in the basal spacing. Thereby, the position of the halide ion in the interlayer gallery is determined by the interplay of Coulombic and hydrogen‐bonding interactions.
Luminescent Properties of RbSrPO4:Eu2+ Phosphors for Near‐UV‐Based White‐Light‐Emitting Diodes
Authors: Yim Dong Kyun , Song Hee Jo , Roh Hee‐Suk , Kim Seung‐Joo , Han Byung Suh , Jin Yun‐Ho , Hong Hyun‐Seon , Kim Dong‐Wan , Hong Kug Sun 
Published: July 2013

AbstractA phosphor based on a phosphate host matrix, RbSrPO4:Eu2+ (RSP), was synthesized by a conventional solid‐state reaction, and the crystal structure of the RSP host material was investigated by Rietveld refinement. The RSP phosphor could be excited efficiently by light in the 220–430 nm UV/Vis range and exhibited a highly intense emission peak at 450 nm. We discovered the effect of the activated Eu2+ concentration and the concentration quenching mechanism. Also, light absorption and quantum efficiency of the RSP phosphor were measured when excited in the near‐UV region. Finally, the effect of temperature on the photoluminescence emission intensity of the RSP phosphor and its thermal activation energy were investigated. All of these characteristics indicate that this phosphor has potential for use in near‐UV‐based white LEDs.
Simple Route to Adducts of (Amino)(aryl)carbene with Phosphorus Pentafluoride
Authors: Guzyr Olexandr I. , Zasukha Sergiy V. , Vlasenko Yurii G. , Chernega Alexander N. , Rozhenko Alexander B. , Shermolovich Yuriy G. 
Published: July 2013

AbstractThe tetramethyl ester of (hydroxy)(phenyl)methylenebis(phosphonic acid) reacts with morpholinosulfur trifluoride (MOST) to provide, along with the expected product of the substitution of a hydroxy group by fluorine, the adduct of (morpholino)(phenyl)carbene with PF5, compound 3a. Fluorination of dimethyl α‐aroylphosphonates with MOST yields adducts of (amino)(aryl)carbene with PF5 (p‐XC6H4)(Morph)C:→PF5 [3a–f, where Morph is morpholyl, X = H (a), Me (b), OEt (c), F (d), Cl (e), CF3 (f)] as the major reaction products. The reaction mechanism proposed is based on experimental data and DFT calculations. The structure of adduct 3a was determined by X‐ray studies. Hydrolysis of compounds 3e and 3f, bearing substituents Cl and CF3 on the phenyl ring, respectively, yields previously unknown benzoylpentafluorophosphates [p‐XC6H4–C(=O)PF5]–MorphH+.
Color‐Tunable Fluorescent Dyes Based on Benzo[c]coumarin
Authors: Krzeszewski Maciej , Vakuliuk Olena , Gryko Daniel T. 
Published: July 2013

AbstractHurtley condensation was shown to be a perfect tool with which to assemble a diversified library of derivatives of benzo[c]coumarin. Not only do simple resorcinols and ortho‐bromobenzoic acids undergo this reaction, but also dihydroxynaphthalenes and 3‐bromothiophene‐2‐carboxylic acid, affording the desired compounds in moderate yields. In the case of naphthalenediols, intriguing regioselectivity is observed, which holds promise for its utilization in the synthesis of previously inaccessible molecules. Further transformation made it possible to obtain benzo[c]coumarin bearing amino and nitro groups at various positions, which served as entry points to prepare complex hybrids of 1,4‐benzoxazin‐2‐ones and benzo[c]coumarins. The hydroxyl group proved to be the synthetic handle, enabling the synthesis of strongly solvatochromic, soluble analogues. The effect of structural variation on photophysical properties was studied in detail for almost 30 compounds. The relationship between the structure and photophysical properties was thoroughly elucidated by comparison with simple analogues (coumarins, benzoxazinones). All of the obtained compounds exhibit moderate to large Stokes shifts (3300–12500 cm–1). The type of π‐expansion of the chromophore strongly influences the overall optical phenomena. Compounds possessing alkyl substituents on the benzo[c]coumarin core have much higher fluorescence quantum yields than their analogues bearing amino, fluorine, and other complex substituents. Interestingly, the product possessing a fused coumarin–thiophene skeleton exhibits over twofold higher fluorescence quantum yield than any of its coumarin–benzene analogues.
Inductive Effects through Alkyl Groups – How Long is Long Enough?
Authors: Tandon Raman , Nigst Tobias A. , Zipse Hendrik 
Published: July 2013

AbstractThe influence of the length of alkyl substituents on various kinetic, thermodynamic, and spectroscopic properties of 4‐(dialkylamino)pyridines has been determined by using a combination of experimental and theoretical methods. The chain‐length dependence of these properties has subsequently been analyzed by using a quantitative model for through‐bond inductive effects.
Conformational Behavior of 1:1 [α/α‐Hydrazino]mer, 1:1 [α/Aza‐β3‐amino]mer and 1:1 [Aza‐β3‐amino/α]mer Series: Three Series of Foldamers
Authors: Acherar Samir , Salaün Arnaud , Le Grel Philippe , Le Grel Barbara , Jamart‐Grégoire Brigitte 
Published: July 2013

AbstractAnalysis of 1H NMR spectroscopic data allowed us to assign the secondary structure of three new series of mixed foldamers. 1:1 [α/aza‐β3‐amino]mers, 1:1 [aza‐β3‐amino/α]mers and 1:1 [α/α‐hydrazino]mers are self‐organized in solution by a hydrogen bond network of alternating a γ‐turn and a hydrazinoturn. Nevertheless, owing to the donor and acceptor H‐bond characters of the amidic NH, 1:1 [α/α‐hydrazino]mers can exist as an equilibrium between pseudospiranic and hydrazinoturn conformations.
Electrochemical Detection of Avian Influenza Virus Genotype Using Amino‐ssDNA Probe Modified Gold Electrodes
Authors: Malecka Kamila , Grabowska Iwona , Radecki Jerzy , Stachyra Anna , Góra‐Sochacka Anna , Sirko Agnieszka , Radecka Hanna 
Published: July 2013

AbstractA DNA biosensor for the detection of specific oligonucleotide sequences of Avian Influenza Virus type H5N1 has been proposed. The NH2‐ssDNA probe was deposited onto a gold electrode surface to form an amide bond between the carboxyl group of thioacid and the amino group from ssDNA probe. The signals generated as a result of hybridization were registered in square wave voltammetry and electrochemical impedance spectroscopy in the presence of [Fe(CN)6]3−/4− as a redox marker. The genosensor is capable to determine 20‐mer and 180‐bp (PCR products) oligonucleotides complementary sequences with detection limit in the fM range. The genosensor displays good selectivity and sensitivity. The 20‐mer as well as 180‐bp oligonucleotides without a complementary sequence generate very low signal.
A Novel Hydrogen Peroxide Biosensor Based on Adsorption of Horseradish Peroxidase onto a Nanobiomaterial Composite Modified Glassy Carbon Electrode
Authors: Moyo Mambo , Okonkwo Jonathan O. , Agyei Nana M. 
Published: July 2013

AbstractIn this work, a novel hydrogen peroxide biosensor derived from maize tassel (MT) and multiwalled carbon nanotube (MWCNT) composite was used to adsorb horseradish peroxidase (HRP) onto the surface of a glassy carbon electrode through electrostatic interactions. The morphology and structure of the products were characterized by SEM, FTIR and UV‐visible spectroscopy. The electrochemical and electrocatalytic performance of the HRP/MT‐MWCNT/GCE was studied using voltammetric and amperometric methods. The amperometric response of the biosensor varied linearly with concentration of H2O2 from 9 µM to 1 mM with detection limit of 4.0 µM (S/N=3). Furthermore, the biosensor exhibited good reproducibility and stability.
Electric Field Driven Extraction of Inorganic Anions Across a Polymer Inclusion Membrane
Authors: Schmidt‐Marzinkowski Julia , See Hong Heng , Hauser Peter C. 
Published: July 2013

AbstractThe potential use of plasticized cellulose acetate membranes for electric field driven extraction and preconcentration of inorganic anions was studied. The extraction of highly lipophilic ions such as perchlorate is possible by employing a membrane without any ion carrier, while anions of low lipophilicity, such as phosphate, require a carrier. Best extraction efficiency could be obtained for a membrane of 20 µm thickness and an applied voltage of 200 V. In a flow‐through arrangement the preconcentration factor was inversely dependent on the flow rate but constant for different concentrations. The extraction of perchlorate down to 2 nM was demonstrated.
Effective and Functional Surface Design for Biosensing Applications Based on a Novel Conducting Polymer and PMMA/Clay Nanocomposite
Authors: Kesik Melis , Kocer Ozgecan , Kanik Fulya Ekiz , Unlu Naime Akbasoglu , Rende Eda , Aslan‐Gurel Evren , Rossi Rene M. , Udum Yasemin Arslan , Toppare Levent 
Published: July 2013

AbstractSurface functionalization plays a crucial role in the design of biosensors. For this purpose, a novel functional monomer, 6‐(4,7‐bis(2,3‐dihydrothieno[3,4‐b][1,4]dioxin‐5‐yl)‐2H‐benzo[d][1,2,3]triazol‐2‐yl)hexan‐1‐amine (BEDOA‐6), was designed and synthesized. Poly(BEDOA‐6) was utilized as an immobilization matrix for glucose oxidase biosensor construction. Moreover, polymethylmethacrylate (PMMA) layered silicate nanocomposites were prepared by in situ suspension polymerization. Conducting polymer surface was modified with PMMA/clay nanocomposite material and a glucose biosensor was developed. In addition, XPS and SEM were utilized to characterize the surface properties. The biosensor shows a wide linear range between 2.8 µM and 1.2 mM to glucose with a low detection limit of 1.99 µM. Finally, the biosensor was tested on serum samples containing actual human blood. The results were in well‐agreement with a reference method.
Force–displacement mixed control for collapse tests of multistory buildings using quasi‐static loading systems
Authors: Pan Peng , Zhao Gang , Lu Xinzheng , Deng Kailai 
Published: July 2013

SUMMARYIn quasi‐static tests for structures with multi‐DOF, the forces exerted to the structures commonly follow a prescribed force profile, for example, triangular pattern and/or uniform pattern. Therefore, force control is the natural choice. However, force control is no longer applicable when the specimens sustain significant stiffness and strength degradation, particularly in collapse tests. To solve this problem, a force–displacement mixed control algorithm is proposed, which is able to achieve stable control in quasi‐static tests following prescribed force profiles. On the basis of the FlexTest IIm platform of the MTS Systems Corporation (14000 Technology Dr, Eden Prairie, MN 55344 United States), a test program named Tsinghua University mixed control test program, which uses a mixed control algorithm, was developed. The algorithm was initially applied to an elastic test of a cantilever column to verify its accuracy and stability and then to a collapse test of a multistory RC frame to investigate its effectiveness. In the collapse test, the effects of major control parameters, that is, the number of iterative rounds and the loading time of each round on the control accuracy, were also studied. The test results show that the test program applying the mixed control algorithm can achieve stable control of the collapse tests maintaining the expected force profile. Increasing the number of iterative rounds and the loading time of each round can improve the control accuracy. Copyright © 2013 John Wiley & Sons, Ltd.
Peripheral inflammatory markers in amnestic mild cognitive impairment
Authors: Karim Salman , Hopkins Steve , Purandare Nitin , Crowther Jackie , Morris Julie , Tyrrell Pippa , Burns Alistair 
Published: July 2013

ObjectiveTo prospectively monitor plasma inflammatory marker concentrations in peripheral blood, over 12 months, in subjects with amnestic mild cognitive impairment (MCI), and to determine the relationship between peripheral inflammatory markers and cognitive decline.MethodsSeventy patients with amnestic MCI were recruited from two sites providing specialist memory assessment services in Manchester. The baseline assessment included physical examination, neuro‐psychological testing and venous blood samples for C‐reactive protein (CRP) and interleukin 6 (IL‐6) concentrations. Sixty two participants were followed up after 12 months and the assessments were repeated.ResultsData analysis revealed a significant rise in CRP, but not IL‐6 concentrations over 12 months, which was not confounded by demographic variables. The neuro‐psychological test scores had no association with CRP or IL‐6 concentrations at baseline or 12 months follow‐up.ConclusionThis study adopted the unique approach of prospectively investigating peripheral inflammatory markers in a cohort with amnestic MCI. A significant rise in CRP concentrations over 12 months, but lack of significant association with cognition, provide no evidence for a relationship between systemic inflammation and cognitive decline in amnestic MCI. © 2013 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons, Ltd.
Quantifying recent acceleration in sea level unrelated to internal climate variability
Authors: Calafat F. M. , Chambers D. P. 
Published: July 2013

AbstractSea level observations suggest that the rate of sea level rise has accelerated during the last 20 years. However, the presence of considerable decadal‐scale variability, especially on a regional scale, makes it difficult to assess whether the observed changes are due to natural or anthropogenic causes. Here we use a regression model with atmospheric pressure, wind, and climate indices as independent variables to quantify the contribution of internal climate variability to the sea level at nine tide gauges from around the world for the period 1920–2011. Removing this contribution reveals a statistically significant acceleration (0.022 ± 0.015 mm/yr2) between 1952 and 2011, which is unique over the whole period. Furthermore, we have found that the acceleration is increasing over time. This acceleration appears to be the result of increasing greenhouse gas concentrations, along with changes in volcanic forcing and tropospheric aerosol loading.