bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of a swine experimental model of non‐occlusive mesenteric ischemia: Combining induced hemorrhagic shock and vasopressor administration
Authors: Tanaka Yasutaka , Matsumura Yosuke , Aoki Makoto , Hayashi Yosuke , Izawa Yoshimitsu , Endo Kazuhiro , Mato Takashi 
Published: July 2024

AbstractAimNon‐occlusive mesenteric ischemia (NOMI) is associated with high mortality rates, but definitive treatments have not yet been established. Although experimental animal models are worthwhile, reproducible models that reflect the pathophysiology of NOMI have not been developed.MethodsWe combined risk factors for NOMI, comprising hemorrhagic shock, systemic vasopressor infusion, and local vasopressor infusion from the superior mesenteric artery (SMA) in swine under maintained anesthesia. Experiment 1 involved full‐intensity (40%) phlebotomy and systemic vasopressor (norepinephrine and epinephrine). Experiment 2 involved full‐intensity (40%) phlebotomy, systemic norepinephrine, and local vasopressor infusion into the SMA. Experiment 3 involved moderate (27%) phlebotomy, systemic norepinephrine infusion, and local epinephrine infusion. We evaluated serum lactate levels, intestinal serosa color, computed tomography (CT) angiography, and pathological findings.ResultsAfter inducing hemorrhage, systemic vasopressor alone and in combination with local vasopressin or norepinephrine infusion did not induce ischemic color changes in the intestine. The combination of systemic norepinephrine and local epinephrine (0.5 μg/kg/min) after moderate (27% blood loss) hemorrhage induced gross color change, pathological destruction, and elevation of serum lactate. Patent flow in the SMA was confirmed on CT angiography.ConclusionWe established a swine NOMI model with systemic norepinephrine infusion and local epinephrine with moderate hemorrhagic shock.
Integrating Multipolar Structures and Carboxyl Groups in sp2‐Carbon Conjugated Covalent Organic Frameworks for Overall Photocatalytic Hydrogen Peroxide Production
Authors: Xu Haocheng , Wang Yandong , Xu Yang , Wang Qiaomu , Zhuang Mingyan , Liao Qiaobo , Xi Kai 
Published: July 2024

AbstractThe direct production of hydrogen peroxide (H2O2) through photocatalytic reaction via H2O and O2 is considered as an ideal approach. However, the efficiency of H2O2 generation is generally limited by insufficient charge and mass transfer. Covalent organic framework (COFs) offer a promising platform as metal‐free photocatalyst for H2O2 production due to their potential for rational design at the molecular level. Herein, we integrated the multipolar structures and carboxyl groups into COFs to enhance the efficiency of photocatalytic H2O2 production in pure water without any sacrificial agents. The introduction of octupolar and quadrupolar structures, along with an increase of molecular planarity, created efficient oxygen reduction reaction (ORR) sites. Meanwhile, carboxyl groups could not only boost O2 and H2O2 movement via enhancement of pore hydrophilicity, but also promote proton conduction, enabling the conversion to H2O2 from ⋅O2−, which is the crucial intermediate product in H2O2 photocatalysis. Overall, we demonstrate that TACOF‐1‐COOH, consisting of optimal octupolar and quadrupolar structures, along with enrichment sites (carboxyl groups), exhibited a H2O2 yield rate of 3542 μmol h− 1 g−1 and a solar‐to‐chemical (SCC) efficiency of 0.55 %. This work provides valuable insights for designing metal‐free photocatalysts for efficient H2O2 production.
P1−xTa8+xN13 (x=0.1–0.15): A Phosphorus Tantalum Nitride Featuring Mixed‐Valent Tantalum and P/Ta Disorder Visualized by Scanning Transmission Electron Microscopy
Authors: Pointner Monika M. , Ceniza Claude , Nusser Lukas , Witthaut Kristian , Wolf Florian , Weidemann Martin , Eisenburger Lucien , Moewes Alexander , Oeckler Oliver , Schnick Wolfgang 
Published: July 2024

AbstractWe report on the synthesis, crystal, and electronic structure, as well as the magnetic, and electric properties of the phosphorus‐containing tantalum nitride P1−xTa8+xN13 (x=0.1–0.15). A high‐pressure high‐temperature reaction (8 GPa, 1400 °C) of Ta3N5 and P3N5 with NH4F as a mineralizing agent yields the compound in the form of black, rod‐shaped crystals. Single‐crystal X‐ray structure elucidation (space group C2/m (no. 12), a=16.202(3), b=2.9155(4), c=11.089(2) Å, β=126.698(7)°, Z=2) shows a network of face‐ and edge‐sharing Ta‐centered polyhedra that contains small vacant channels and PN6 octahedra strands. Atomic resolution transmission electron microscopy reveals an unusual P/Ta disorder. Mixed‐valent tantalum atoms exhibit interatomic distances similar to those in metallic tantalum, however, the electrical resistivity is quite high in the order of 101 Ω cm. The density of states and the electron localization function indicate localized electrons in both covalent and ionic bonds between P/Ta and N atoms, combined with less localized electrons that do not contribute to interatomic bonds.
Modular Assembly of Acridines by Integrating Photo‐Excitation of o‐Alkyl Nitroarenes with Copper‐Promoted Cascade Annulation
Authors: Huang Haichao , Jiang Yifan , Yuan Wei , Lin Yu‐Mei 
Published: July 2024

AbstractAcridine frameworks stand as pivotal architectural elements in pharmaceuticals and photocatalytic applications, owing to their chemical adaptability, biological activity, and unique excited‐state dynamics. Conventional synthetic routes often entail specialized starting materials, anaerobic or moisture‐free conditions, and elaborate multi‐stage manipulations for incorporating diverse functionalities. Herein, we present a convergent approach integrating photo‐excitation of readily available ortho‐alkyl nitroarenes with copper‐promoted cascade annulation. This innovative system enables an aerobic, one‐pot reaction of o‐alkyl nitroarenes with arylboronic acids, thereby streamlining the modular construction of a wide array of acridine derivatives with various functional groups. This encompasses symmetrical, unsymmetrical and polysubstituted varieties, some of which are otherwise exceptionally difficult to synthesize. Furthermore, it significantly improves the production of structurally varied acridinium salts, featuring enhanced photophysical properties, high excited state potentials (E*red=2.08–3.15 V), and exhibiting superior performance in intricate photoredox transformations.
Surface Gradient Desodiation Chemistry in Layered Oxide Cathode Materials
Authors: Jiang Na , Yu Jiangtao , Wu Zhonghan , Zhao Jiahua , Zeng Yuyao , Li Haixia , Meng Miao , He Yutong , Jiao Peixin , Pan Hongchuang , Wang Huili , Qi Jianing , Hu Zhe , Zhang Kai , Chen Jun 
Published: July 2024

AbstractSodium‐ion batteries (SIBs) as a promising technology for large‐scale energy storage have received unprecedented attention. However, the cathodes in SIBs generally suffer from detrimental cathode‐electrolyte interfacial side reactions and structural degradation during cycling, which leads to severe capacity fade and voltage decay. Here, we have developed an ultra‐stable Na0.72Ni0.20Co0.21Mn0.55Mg0.036O2 (NCM‐CS‐GMg) cathode material in which a Mg‐free core is encapsulated by a shell with gradient distribution of Mg using coprecipitation method with Mg‐hysteretic cascade feedstock followed by calcination. From the interior to outer surface of the shell, as the content of electrochemically inactive Mg gradually increases, the Na+ deintercalation amount gradually decreases after charged. Benefiting from this surface gradient desodiation, the surface transition metal (TM) ion migration from TM layers to Na layers is effectively inhibited, thus suppressing the layered‐to‐rock‐salt phase transition and the resultant microcracks. Besides, the less formation of high‐valence TM ions on the surface contributes to a stable cathode‐electrolyte interface. The as‐prepared NCM‐CS‐GMg exhibits remarkable cycling life over 3000 cycles with a negligible voltage drop (0.127 mV per cycle). Our findings highlight an effective way to developing sustainable cathode materials without compromising on the initial specific capacity for SIBs.
Formulating Self‐Repairing Solid Electrolyte Interface via Dynamic Electric Double Layer for Practical Zinc Ion Batteries
Authors: Qin Siqi , Zhang Jie , Xu Mi , Xu Peiwen , Zou Jiabin , Li Jianhui , Luo Dan , Zhang Yongguang , Dou Haozhen , Chen Zhongwei 
Published: July 2024

AbstractZinc ion batteries (ZIBs) encounter interface issues stemming from the water‐rich electrical double layer (EDL) and unstable solid‐electrolyte interphase (SEI). Herein, we propose the dynamic EDL and self‐repairing hybrid SEI for practical ZIBs via incorporating the horizontally‐oriented dual‐site additive. The rearrangement of distribution and molecular configuration of additive constructs the robust dynamic EDL under different interface charges. And, a self‐repairing organic–inorganic hybrid SEI is constructed via the electrochemical decomposition of additive. The dynamic EDL and self‐repairing SEI accelerate interfacial kinetics, regulate deposition and suppress side reactions in the both stripping and plating during long‐term cycles, which affords high reversibility for 500 h at 42.7 % depth of discharge or 50 mA ⋅ cm−1. Remarkably, Zn//NVO full cells deliver the impressive cycling stability for 10000 cycles with 100 % capacity retention at 3 A ⋅ g−1 and for over 3000 cycles even at lean electrolyte (7.5 μL ⋅ mAh−1) and high loading (15.26 mg ⋅ cm−2). Moreover, effectiveness of this strategy is further demonstrated in the low‐temperature full cell (−30 °C).
Cation‐Dependent Mixed Ionic‐Electronic Transport in a Perylenediimide Small‐Molecule Semiconductor
Authors: Yu Simiao , Wu Han‐Yan , Lemaur Vincent , Kousseff Christina J. , Beljonne David , Fabiano Simone , Nielsen Christian B. 
Published: July 2024

AbstractA rapidly growing interest in organic bioelectronic applications has spurred the development of a wide variety of organic mixed ionic‐electronic conductors. While these new mixed conductors have enabled the community to interface organic electronics with biological systems and efficiently transduce biological signals (ions) into electronic signals, the current materials selection does not offer sufficient selectivity towards specific ions of biological relevance without the use of auxiliary components such as ion‐selective membranes. Here, we present the molecular design of an n‐type (electron‐transporting) perylene diimide semiconductor material decorated with pendant oligoether groups to facilitate interactions with cations such as Na+ and K+. Using the cyclic 15‐crown‐5 oligoether motif, we find that the resulting mixed conductor PDI‐crown displays a strong dependence on the size of the electrolyte cation when tested in an organic electrochemical transistor configuration. In stark contrast to the low current response on the order of 1 μA observed with aqueous sodium chloride, a nearly 200‐fold increase in current is observed with aqueous potassium chloride. We ascribe the high selectivity to extended molecular aggregation and therefore efficient charge transport in the presence of K+ due to a favourable sandwich‐like structure between two adjacent 15‐crown‐5 motifs and the potassium ion.
Nanoarchitectonics of Vesicle Microreactors for Oscillating ATP Synthesis and Hydrolysis
Authors: Wang Tonghui , Fei Jinbo , Yu Fanchen , Xu Xia , Cui Yue , Li Junbai 
Published: July 2024

AbstractWe construct a compartmentalized nanoarchitecture to regulate bioenergy level. Glucose dehydrogenase, urease and nicotinamide adenine dinucleotide are encapsulated inside through liquid‐liquid phase separation. ATPase and glucose transporter embedded in hybrid liposomes are attached at the surface. Glucose is transported and converted to gluconic acid catalyzed by glucose dehydrogenase, resulting in an outward proton gradient to drive ATPase for ATP synthesis. In parallel, urease catalyzes hydrolysis of urea to generate ammonia, which leads to an inward proton gradient to drive ATPase for ATP hydrolysis. These processes lead to a change of the direction of proton gradient, thus achieving artificial ATP oscillation. Importantly, the frequency and the amplitude of the oscillation can be programmed. The work explores nanoarchitectonics integrating multiple components to realize artificial and precise oscillation of bioenergy level.
Classification Criteria for Axial Disease in Youth With Juvenile Spondyloarthritis
Authors: Weiss Pamela F. , Brandon Timothy G. , Aggarwal Amita , Burgos‐Vargas Ruben , Colbert Robert A. , Horneff Gerd , Laxer Ronald M. , Minden Kirsten , Ravelli Angelo , Ruperto Nicolino , Smith Judith A. , Stoll Matthew L. , Tse Shirley M. , Van den Bosch Filip , Maksymowych Walter P. , Lambert Robert G. , Biko David M. , Chauvin Nancy A. , Francavilla Michael L. , Jaremko Jacob L. , Herregods Nele , Kasapcopur Ozgur , Yildiz Mehmet , Srinivasalu Hemalatha , Lovell Daniel J. , Nigrovic Peter A. , Foeldvari Ivan , Klein‐Gitelman Marisa S. , Ozen Seza , Naden Ray , Hendry Alison M. , Joos Rik 
Published: July 2024

ObjectiveThe goal was to develop and validate classification criteria for axial juvenile spondyloarthritis (SpA; AxJSpA).MethodsThis international initiative consisted of four phases: (1) item generation, (2) item reduction, (3) criteria development, and (4) validation of the AxJSpA criteria by an independent team of experts in an internationally representative validation cohort.ResultsThese criteria are intended to be used on youth with a physician diagnosis of juvenile SpA and for whom axial disease is suspected. Item generation consisted of a systematic literature review and a free‐listing exercise using input from international physicians, which collectively resulted in 108 items. After the item reduction exercise and expert panel input, 37 items remained for further consideration. The final AxJSpA criteria domains included the following: imaging of active inflammation, imaging of structural lesions, pain chronicity, pain pattern, pain location, stiffness, and genetics. The most heavily weighted domains were active inflammation and structural lesions on imaging. Imaging typical of sacroiliitis was deemed necessary, but not sufficient, to classify a youth with AxJSpA. The threshold for classification of AxJSpA was a score of ≥55 (out of 100). When tested in the validation data set, the final criteria had a specificity of 97.5% (95% confidence interval [CI] 91.4%–99.7%), sensitivity of 64.3% (95% CI 54.9%–73.1%), and area under the receiver operating characteristic curve of 0.81 (95% CI 0.76%–0.86%).ConclusionThe new AxJSpA classification criteria require an entry criterion and a physician diagnosis of juvenile SpA and include seven weighted domains. The AxJSpA classification criteria are validated and designed to identify participants for research studies.image
The role of information and communication technologies in disclosing and reporting sexual assault among young adults: A systematic review. An Annual Review of Information Science and Technology (ARIST) paper
Authors: Lookingbill Valerie , Wagner Travis L. 
Published: July 2024

AbstractAs survivors have complex and varied motivations for disclosing sexual assault, information and communication technologies (ICTs) can offer unique affordances that either facilitate or hinder sexual assault disclosures. In response, this systematic review draws connections between the functions of sexual assault disclosures and how ICT design choices can impact the sexual assault disclosure process. Findings from 23 empirical studies indicate that platform affordances can facilitate sexual assault survivors' motivations of visibility, naming sexual assault experiences, anonymity, and destigmatizing sexual assault. Further, findings categorize ICT‐based sexual assault disclosure within three frames: disclosure as a linguistic act, disclosure as a reciprocal act, and disclosure as a cultural response. In turn, findings from this systematic review reveal a need for a better understanding of how ICTs function as counter‐discursive information spaces and identify important considerations for redesigning ICTs to allow for sexual assault disclosure work to flourish.
An Acid‐Activatable Fluorescent Probe for Sulfur Dioxide in Traditional Chinese Medicines and Living Cells
Authors: Xi Guan , Liu Mei , Zhou Peitao , Yu Congting , Zhang Fan , Zhang Zhenqiang , Zhang Wenli , Luan Tiangang 
Published: July 2024

AbstractExcessive sulfur dioxide (SO₂) disturbs physiology of lysosomes causing diseases and threatening human health. A fluorescent probe has been regarded as one of the most attractive approaches, which is compatible with living cells and possesses high sensitivity. However, most of fluorescent probes’ reaction sites are activated before they reach the destination. In this work, an acid‐activatable fluorescent probe PT1 was synthesized, characterized, and used for SO2 detection. The introduction of oxazolines in PT1 enables the intelligent response of probe to release the activation stie for SO2 derivatives through Michael addition upon exposure to acid. In vitro studies showed a remarkable selectivity of PT1 to SO₂ derivatives than other biothiols with a limit of detection as low as 62 nM. By using this acidic pH‐controlled fluorescence responsiveness to SO₂, precise spatiotemporal identification of lysosomal SO2 fluctuations has been successfully performed. Furthermore, probe PT1 can be applied for monitoring SO₂ derivatives in traditional Chinese medicines.
Characteristics and correlates of aggressive behavior in autistic youths
Authors: Brown Cynthia E. , Borduin Charles M. , Sheerin Kaitlin M. , Kanne Stephen M. 
Published: July 2024

AbstractThis study aimed to characterize aggressive behaviors in autistic youths and to identify the social environment variables most strongly linked with aggression in this clinical population. Participants were 2142 caregivers of autistic youths (ages 6.0–17.9) recruited from autism research centers across the United States. Caregivers completed self‐report and behavior rating inventories that assessed both verbal and physical aggression as well as characteristics of the individual youths (sleep quality, gastrointestinal [GI] symptoms, and autism characteristics) and their families (caregiver stress, global family functioning, and sibling relations), peers (emotional bonding, number of friends), schools (academic functioning), and neighborhoods (perceived community safety). We used descriptive analyses to identify which aggressive acts were most common among autistic youths, and we performed bivariate correlations and multiple linear regression analyses to determine which characteristics of the youths and their social environments were most strongly linked with youth aggression. Verbally aggressive youth behaviors were endorsed by caregivers most frequently. Youth age and sex were not associated with verbal or physical aggression. A combination of youth and social environment characteristics accounted for 42.6% of the variance in verbal aggression and 26.0% of the variance in physical aggression. Thus, those characteristics most strongly linked with verbal and physical aggression were strained sibling relations, caregiver stress, youth sleep problems, and youth repetitive and restrictive behaviors. Viewed together, the results suggest that aggressive behaviors in autistic youths are associated with multiple characteristics pertaining to the individual youths and their immediate social environments. Implications for treatment and research are discussed.
Characterization of G‐quadruplexes in the Helicobacter pylori genome and assessment of therapeutic potential of G4 ligands
Authors: Kumari Monika , Jaiswal Saumya , Shankar Uma , Gupta Sharad , Pradeepkumar Pushpangadan Indira , Kumar Amit , Nayak Debasis , Yadav Vikas , Yadav Puja 
Published: July 2024

AbstractHelicobacter pylori, a leading human pathogen associated with duodenal ulcer and gastric cancer, presents a significant threat to human health due to increasing antibiotic resistance rates. This study investigates G‐quadruplexes (G4s), which are non‐canonical secondary structures form in G‐rich regions within the H. pylori genome. Extensive research on G4s in eukaryotes has revealed their role in epigenetically regulating cellular processes like gene transcription, DNA replication, and oncogene expression. However, understanding of G4‐mediated gene regulation in other organisms, especially bacterial pathogens, remains limited. Although G4 motifs have been extensively studied in a few bacterial species such as Mycobacterium, Streptococci, and Helicobacter, research on G4 motifs in other bacterial species is still sparse. Like in other organisms such as archaea, mammals, and viruses, G4s in H. pylori display a non‐random distribution primarily situated within open reading frames of various protein‐coding genes. The occurrence of G4s in functional regions of the genome and their conservation across different species indicates that their placement is not random, suggesting an evolutionary pressure to maintain these sequences at specific genomic sites. Moreover, G‐quadruplexes show enrichment in specific gene classes, suggesting their potential involvement in regulating the expression of genes related to cell wall/membrane/envelope biogenesis, amino acid transport, and metabolism. This indicates a probable regulatory role for G4s in controlling the expression of genes essential for H. pylori survival and virulence. Biophysical techniques such as Circular Dichroism spectroscopy and Nuclear Magnetic Resonance were used to characterize G4 motifs within selected H. pylori genes. The study revealed that G‐quadruplex ligand inhibited the growth of H. pylori, with minimal inhibitory concentrations in the low micromolar range. This suggests that targeting G4 structures could offer a promising approach for developing novel anti‐H. pylori drugs.
Assessment of remdesivir and its nucleoside metabolite in beagle dogs and healthy humans by liquid chromatography coupled with triple quadrupole mass spectrometry
Authors: Dubey Naveen Kumar , Jain Peeyush , Raj Ankit , Tiwari Sandeep 
Published: July 2024

AbstractThe aim of this study was to assess the pharmacokinetics of the existing remdesivir intravenous formulation (100 mg dose) against the newly developed oral formulation (20 mg dose) for remdesivir and its active nucleoside metabolite (GS‐441524) in beagle dogs followed by healthy human volunteers. A quantification method for remdesivir and its active nucleoside metabolite (GS‐441524) in beagle dog and human plasma has been developed and validated using liquid chromatography coupled to triple quadrupole mass spectrometry detection. The analytical methods for beagle dogs and human differ in the calibration curve range, plasma matrix, processing volume, reconstitution volume and injection volume; however all other parameters were same in both methods. A simple protein precipitation extraction was carried out using acetonitrile containing the internal standard remdesivir D5. Remdesivir and GS‐441524 were separated on an Endurus C‐18P, 100 × 4.6 mm, 3 μm column and detected using a mass spectrometer with electrospray ionization in positive ion mode. The ion transitions used were m/z 603.1 → m/z 200.0 for remdesivir, m/z 292.0 → m/z 202.2 for GS‐441524 and m/z 608.2 → m/z 205.1 for remdesivir D5. The calibration curve results were linear in beagle dog plasma (2.0–2,000.8 ng/ml range for remdesivir and 2.0–1,500.4 ng/ml for GS‐441524) and human plasma (30.0–4,503.9 ng/ml range for remdesivir and 2.0–200.4 ng/ml for GS‐441524). The recovery was >90% in beagle dog and human plasma. These methods were successfully used to determine the pharmacokinetic parameters of the intravenous injection and subcutaneous tablets dosage forms in beagle dogs and healthy humans.