bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial AXL and MCL‐1 inhibition contributes to abolishing lazertinib tolerance in EGFR‐mutant lung cancer cells
Authors: Matsui Yohei , Yamada Tadaaki , Katayama Yuki , Hirai Soichi , Sawada Ryo , Tachibana Yusuke , Ishida Masaki , Kawachi Hayato , Nakamura Ryota , Nishioka Naoya , Morimoto Kenji , Iwasaku Masahiro , Horinaka Mano , Sakai Toshiyuki , Tokuda Shinsaku , Takayama Koichi 
Published: July 2024

AbstractLazertinib, a novel third‐generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI), demonstrates marked efficacy in EGFR‐mutant lung cancer. However, resistance commonly develops, prompting consideration of therapeutic strategies to overcome initial drug resistance mechanisms. This study aimed to elucidate the adaptive resistance to lazertinib and advocate novel combination treatments that demonstrate efficacy in preventing resistance as a first‐line treatment for EGFR mutation‐positive NSCLC. We found that AXL knockdown significantly inhibited lung cancer cell viability in the presence of lazertinib, indicating that AXL activation contributes to lazertinib resistance. However, long‐term culture with a combination of lazertinib and AXL inhibitors led to residual cell proliferation and increased the MCL‐1 expression level, which was mediated by the nuclear translocation of the transcription factor YAP. Triple therapy with an MCL‐1 or YAP inhibitor in combination with lazertinib and an AXL inhibitor significantly reduced cell viability and increased the apoptosis rate. These results demonstrate that AXL and YAP/MCL‐1 signals contribute to adaptive lazertinib resistance in EGFR‐mutant lung cancer cells, suggesting that the initial dual inhibition of AXL and YAP/MCL‐1 might be a highly effective strategy in eliminating lazertinib‐resistant cells.
Transition metal complexes of hydrazones as potential antimicrobial and anticancer agents: A short review
Authors: Czyżewska Izabela , Mazur Liliana , Popiołek Łukasz 
Published: July 2024

AbstractHydrazones display an interesting profile of biological activities, which includes mainly antimicrobial and antiproliferative properties. Hydrazones also play an important role in the synthesis of heterocyclic rings and in coordination chemistry. Currently, the synthesis of complexes of hydrazones with transition metals is quite frequently reported in the scientific literature. The interest in this topic is largely due to diverse biological activities of the metal complexes of hydrazones that in some cases are much more effective than hydrazones themselves. This review focuses on the complexes of hydrazones with transition metals which display antibacterial, antitubercular, antifungal and anticancer activities. In the following subchapters devoted to a given activity, an attempt has been made to present the most active complexes of hydrazones, their trends in their activity and application in medicinal chemistry. The paper presents the literature data from 2009 to 2023. This review constitutes a useful guide for the researchers who intend to synthesize and investigate complexes of hydrazones in terms of their antimicrobial and anticancer activities.
The NIH Infant and Toddler Toolbox: A new standardized tool for assessing neurodevelopment in children ages 1–42 months
Authors: Gershon Richard , Novack Miriam A. , Kaat Aaron J. 
Published: July 2024

AbstractThe progress of developmental research demands reliable measurement techniques, yet inconsistency persist across laboratories, subfields, and settings. To address this, the NIH Toolbox for Neurological and Behavioral Function (NIHTB)® has been extended to create a universal assessment for developmental and pediatric communities: The NIH Infant and Toddler (“Baby”) Toolbox. Currently undergoing norming in a sample of 2550 children demographically representative of the 2020 U.S. census, the Baby Toolbox is slated for release in late 2024. This paper introduces the Baby Toolbox, details its objectives, development, and technological innovations, describes plans for reliability and norming, and invites researchers to consider the Baby Toolbox in the future studies. Ultimately, this initiative stands to enhance cross‐study comparability and advance comprehensive developmental evaluation.
Milk, money, and gender: Exploring the link between women's decision‐making in dairy production and welfare investments in boys versus girls
Authors: Lin Jessie , Wollni Meike 
Published: July 2024

AbstractGreater women's bargaining power and decision‐making within a household have been shown to increase investments in human capital. This study links women's participation in decision‐making in dairy production with household investment in girls and boys in health, nutrition, and education. We survey households in the urbanizing region of Bangalore, India. We utilize a multinomial treatment effects model to analyze the individual and household factors that are associated with women's participation in sole or joint decision‐making. We then assess how the type of decision‐making influences a household's investments. The results first show that female decision‐making households are more disadvantaged on average than other types of decision‐making households. Second, we observe that female decision‐makers for dairy production are more likely to have more children and earn a higher income than their husbands. Third, the main findings show that households in which women engage in joint decision‐making have higher levels of investment across all categories for girls. Conversely, investments decrease in education and nutrition for both girls and boys when the wife is the sole decision‐maker. Lastly, investments are enhanced further for girls when households can sell milk at a higher price.
A new metric for conducting 5‐year reviews to evaluate recovery progress under the Endangered Species Act
Authors: Davis Olivia N. , Molano‐Flores Brenda , Li Ya‐Wei , Allen Maximilian L. , Davis Mark A. , Parkos Joseph J. , McIntyre Susan , Di Giovanni Alexander J. , McElrath Thomas C. , Carter Andrew , Evansen Megan , Sheehan Connor , Gerber Leah R. 
Published: July 2024

AbstractThe Endangered Species Act (ESA) provides legal protection to imperiled populations and their associated habitats. As a part of this process, listed species must undergo a general status review (also called 5‐Year Review) to assess the progress toward recovery every 5 years. However, almost all 5‐year reviews result in a status of “no change,” prompting scientists to question if the review process is robust enough to detect changes in recovery. The U.S. Fish and Wildlife Service (USFWS) was therefore interested in developing a standardized metric for monitoring more nuanced recovery progress as part of the status review. In collaboration with the USFWS, over 75 biologists from five different organizations developed and tested a set of novel metrics to summarize recovery progress of listed species by considering current and future conditions, threats, and conservation measures. We found that, although the majority of species had reviews with a recommendation of no change, scorers were able to use the metrics to interpret more nuanced changes in the 3Rs (resiliency, redundancy, and representation), threats, and conservation measures than in the status review. Our results suggest that these metrics could illuminate more nuanced areas of recovery and decline in species' conditions, but consistency among scorers and status reports should be a focus of future development. Our approach offers a rigorous set of metrics to systematically track the recovery progress of all ESA species.
Strategic land conservation: An applied, multi‐target approach to prioritization of resilient sites for protection
Authors: Hunt Hilary Habeck , Baker Kathleen , Lettow Mitchell C. , Howe Bruce , Fuller Nate 
Published: July 2024

AbstractLand trusts have historically selected many project sites opportunistically, awaiting communication from willing sellers or donors interested in conserving their land. However, in light of the multiple ecological crises faced by land trusts, including climate change, biodiversity loss, and habitat destruction, there is a growing awareness of the need to practice land conservation with an increased pace, scale, and efficacy. In answer to that challenge, we provide one example of how a land trust can adopt methodology for the strategic selection of land protection project sites. Strategic land conservation, as demonstrated in this paper, involves thoughtful prioritization of the attributes of future conservation project sites. Following prioritization, spatial analysis of the region is conducted to identify sites that meet the prioritized attributes, in this case, resilience to climate change. The case study explored in this paper is the 2020 Strategic Land Conservation Plan created by Southwest Michigan Land Conservancy and its partners.
Crisis interpreting and Deaf community understanding during the COVID‐19 pandemic: results from a South Korea‐based survey
Authors: Jo Charmhun 
Published: July 2024

AbstractThis study explores the South Korean Deaf community's response to sign language interpreting during the COVID‐19 (coronavirus disease 2019) health crisis, focusing on individual factors affecting the signers' comprehension. The data were collected from a mobile‐based questionnaire survey conducted among 401 Deaf adults; binary probit modelling was adopted to analyse the data. The major findings are: (i) 59.9 per cent of the respondents understood less than 70 per cent of the interpreting; (ii) males and urban residents tend to understand better; (iii) younger people (less than 50 years) and signers with a Bachelor's degree or higher are likely to have lower comprehension; and (iv) Deaf adults who visited a doctor after the COVID‐19 outbreak tended to have lower comprehension. The findings demonstrate that individual characteristics, including age, impact significantly on the extent to which Deaf individuals understand the sign language interpreting of COVID‐19 information, indicating that steps are needed to achieve a Deaf‐inclusive society during a health disaster.
Time trends in hypertension and diabetes prevalence by body mass index categories in Brazilian adults from 2006 to 2023
Authors: Rezende Leandro F. M. , de Almeida‐Pittito Bianca , Wahrhaftig Jacqueline , Matos Bruna , Ferrari Gerson , da Silva Luiza Eunice Sá , de Oliveira Cardoso Letícia , Maciel Ethel , Claro Rafael 
Published: July 2024

AbstractAimThe prevalence of diabetes and hypertension according to body mass index (BMI) status in Brazilian adults has not been described yet. Herein, we aimed to identify the time trends in hypertension and diabetes, individually and combined (multimorbidity), by BMI in Brazilian adults.MethodsIn this time series cross‐sectional study, we retrieved self‐reported data from 806 169 adults between 2006 and 2023, using the Surveillance System of Risk and Protective Factors from Chronic Diseases by Telephone Survey (Vigitel). Weight and height were used to classify participants into normal/underweight (<25 kg/m2), pre‐obesity (25 to 29.9 kg/m2), and obesity (≥ 30 kg/m2). We calculated the prevalence of medical diagnoses of hypertension and diabetes, individually and combined, by BMI categories, and by sociodemographic characteristics (sex, age group, educational attainment) for participants with obesity. We performed Prais‐Winsten linear regression models to identify temporal trends.ResultsThe prevalence of hypertension and diabetes increased between 2006 and 2023. Among adults with obesity, we observed a slight decrease in the prevalence of hypertension (from 44.5% in 2006 to 41.7% in 2023) and the prevalence of either hypertension or diabetes (47.1% to 45.5%); an increase in the prevalence of diabetes (12.8% to 15.13) and both conditions combined (10.2% to 11.2%). Participants with obesity had more than twice the prevalence of hypertension and diabetes compared with those who were normal/underweight. We observed a differential time trend by sex, age group, and educational attainment.ConclusionOur findings indicate the need for differentiated approaches for interventions for hypertension and diabetes, considering variations over time by sociodemographic characteristics.
Effectiveness of switching from dipeptidyl peptidase‐4 inhibitor to oral glucagon‐like peptide‐1 receptor agonist in Japanese participants with type 2 diabetes mellitus: Prospective observational study using propensity score matching
Authors: Iwamoto Hideyuki , Kimura Tomohiko , Fushimi Yoshiro , Iwamoto Masahiro , Tatsumi Fuminori , Sanada Junpei , Iwamoto Yuichiro , Katakura Yukino , Shimoda Masashi , Nakanishi Shuhei , Mune Tomoatsu , Kaku Kohei , Kaneto Hideaki 
Published: July 2024

AbstractAimRecently, the development of the oral glucagon‐like peptide‐1 receptor agonist semaglutide has drawn a great deal of attention. This study aimed to compare the effectiveness of oral glucagon‐like peptide‐1 receptor agonist semaglutide and dipeptidyl peptidase‐4 (DPP‐4) inhibitors on glycaemic control and several metabolic parameters in patients with type 2 diabetes mellitus over a 6‐month period.MethodsFifty‐nine participants were included, and we compared various clinical parameters between before and after switching from DPP‐4 inhibitors to oral semaglutide in ‘study 1’ (pre‐post comparison) and set the control group using the propensity score matching method in ‘study 2’.ResultsIn ‘study 1’, 6 months after the switching, the glycated haemoglobin value was significantly reduced from 7.5% to 7.0%, and the body mass index was also decreased from 29.7 kg/m2 to 28.8 kg/m2. Such effects were more clearly observed in participants whose glycaemic control was poor. In ‘study 2’, after 1:1 propensity score matching, 51 participants from each group were matched, and glycaemic control as well as body weight management were improved in the switching group compared with the DPP‐4 inhibitor continuation group over the 6‐month observation period.ConclusionIn this study, including obese participants with poor glycaemic control, switching DPP‐4 inhibitors to oral semaglutide showed more beneficial effects on both glycaemic and weight control, irrespective of age, body weight and diabetes duration. Therefore, we should bear in mind that it would be better to start using an oral semaglutide in clinical practice, particularly in obese participants with poor glycaemic control with DPP‐4 inhibitors.
Impact of gender in patients with device‐related thrombosis after left atrial appendage closure – A sub‐analysis from the multicenter EUROC‐DRT‐registry
Authors: Saw Jacqueline , Vij Vivian , Galea Roberto , Piayda Kerstin , Nelles Dominik , Vogt Lara , Gloekler Steffen , Fürholz Monika , Meier Bernhard , Räber Lorenz , O'Hara Gilles , Arzamendi Dabit , Agudelo Victor , Asmarats Lluis , Freixa Xavier , Flores‐Umanzor Eduardo , De Backer Ole , Sondergaard Lars , Nombela‐Franco Luis , Salinas Pablo , Korsholm Kasper , Nielsen‐Kudsk Jens Erik , Zeus Tobias , Operhalski Felix , Schmidt Boris , Montalescot Gilles , Guedeney Paul , Iriart Xavier , Miton Noelie , Gilhofer Thomas , Fauchier Laurent , Veliqi Egzon , Meincke Felix , Petri Nils , Nordbeck Peter , Gonzalez‐Ferreiro Rocio , Cruz‐González Ignacio , Bhatt Deepak L , Laricchia Alessandra , Mangieri Antonio , Omran Heyder , Schrickel Jan Wilko , Beiert Thomas , Rodes‐Cabau Josep , Nickenig Georg , Sievert Horst , Sedaghat Alexander , Afzal Shazia 
Published: July 2024

AbstractBackgroundDevice‐related thrombosis (DRT) is a common finding after left atrial appendage closure (LAAC) and is associated with worse outcomes. As women are underrepresented in clinical studies, further understanding of sex differences in DRT patients is warranted.Methods and ResultsThis sub‐analysis from the EUROC‐DRT‐registry compromises 176 patients with diagnosis of DRT after LAAC. Women, who accounted for 34.7% (61/176) of patients, were older (78.0 ± 6.7 vs. 74.9 ± 9.1 years, p = .06) with lower rates of comorbidities. While DRT was detected significantly later in women (173 ± 267 vs. 127 ± 192 days, p = .01), anticoagulation therapy was escalated similarly, mainly with initiation of novel oral anticoagulant (NOAC), vitamin K antagonist (VKA) or heparin. DRT resolution was achieved in 67.5% (27/40) of women and in 75.0% (54/72) of men (p = .40). In the remaining cases, an intensification/switch of anticoagulation was conducted in 50.% (9/18) of men and in 41.7% (5/12) of women. Final resolution was achieved in 72.5% (29/40) cases in women, and in 81.9% (59/72) cases in men (p = .24). Women were followed‐up for a similar time as men (779 ± 520 vs. 908 ± 687 days, p = .51). Kaplan–Meier analysis revealed no difference in mortality rates in women (Hazard Ratio [HR]: 1.73, 95%‐Confidence interval [95%‐CI]: .68–4.37, p = .25) and no differences in stroke (HR: .83, 95%‐CI: .30–2.32, p = .72) within 2 years after LAAC.ConclusionEvaluation of risk factors and outcome revealed no differences between men and women, with DRT in women being diagnosed significantly later. Women should be monitored closely to assess for DRT formation/resolution. Treatment strategies appear to be equally effective.
Have epilepsy outcomes changed for children with tuberous sclerosis complex in Queensland, Australia?
Authors: Braun Melissa , Riney Kate 
Published: July 2024

AbstractObjectiveHistorically, epilepsy has been the most frequently presenting feature of tuberous sclerosis complex (TSC). Advances in TSC health care have occurred over the past decade; thus, we studied whether TSC epilepsy outcomes have changed.MethodA retrospective chart review was undertaken for all children with TSC in Queensland, Australia. Epilepsy outcome and TSC diagnosis data were extracted, and data were compared between children born before 2012 with those born in or after 2012.ResultsIn this retrospective cohort, TSC diagnosis in children born in or after 2012 is now predominantly antenatal (51%, p < .05). Most patients with epilepsy are now known to have TSC before they develop epilepsy. Despite earlier TSC diagnosis, the frequency of epilepsy (85%) has not changed (p = .92), but diagnosis trends toward an earlier age (median = 3 months for patients born in or after 2012 vs. 5.5 months for those born before 2012, p = .23). Most (95%) patients had focal seizures as their initial clinical seizure type; it was rare (5%) for epileptic spasms (ES) to be the initial seizure type. The frequency of ES was lower in patients born in or after 2012 (36% vs. 50%, p = .27). Infantile (<24 months) onset ES was not associated with worse epilepsy outcome. Late onset ES was seen in 14%, and these patients had a lower rate of epilepsy remission. Lennox–Gastaut syndrome was seen in 7%. Febrile/illness‐related status epilepticus occurred in 12% of patients, between 1 and 4 years of age. Despite many (78%) patients having multiple daily seizures at maximal seizure frequency, and 74% meeting criteria for treatment‐refractory epilepsy, most patients achieved epilepsy remission (66%), either with epilepsy surgery (47%) or with age (53%). At the time of inclusion in this study, only 21% of patients had uncontrolled frequent (daily to 3 monthly) seizures and 14% had uncontrolled infrequent (3 monthly to <2 yearly) seizures.SignificanceThis study provides updated information that informs the counseling of parents of newly diagnosed pediatric TSC patients.
Effects of random meso‐defects on fatigue behavior of welded joints: Damage evolution and lifetime prediction
Authors: Xu Mengyue , Huang Xin , Li Shaolin , Qi Hongyu , Yang Xiaoguang , Shi Duoqi 
Published: July 2024

AbstractRandom meso‐scale defects within welded joints can affect the structural damage process and cause dispersion in the fatigue lifetime of welded joints. In this paper, a meso‐scale stochastic damage approach is used to investigate the effect of random, meso‐scale defects on the fatigue damage lifetime of welded joints under different loads. First, we established an elastic–plastic fatigue damage model considering meso‐defects in the weld metal. Secondly, the fatigue lifetimes for gas tungsten arc welding and gas metal arc welding welded joints were predicted, with most of the predictions within the twofold dispersion factor. Thirdly, the Monte Carlo simulation method was used to investigate the influence of meso‐defect size on the fatigue lifetime dispersion degree, and the fatigue lifetime distribution under different loads was statistically analyzed.
High‐beta stock valuation around macroeconomic announcements
Authors: Chen Jingjing , Jiang George J. 
Published: July 2024

AbstractWe document a dramatic swing of high‐beta stock returns around pre‐scheduled macroeconomic announcements—from being negative on the day before, to positive on the day of, and negative again on the day after the announcements. A feasible long‐short strategy of betting against beta (BAB) and betting on beta (BOB) yields annualized 25.28% return over the 3‐day announcement window. We explore potential explanations based on liquidity, risk, and investor risk appetite. Our results show that changes in liquidity, risk, and investor risk appetite around the announcements at best partially account for variations in high‐beta stock returns. The finding of our study highlights the dynamic effect of macroeconomic announcements on asset prices.
In the eye of the storm: Street‐level organizations in circumstances of democratic backsliding
Authors: Gofen Anat 
Published: July 2024

AbstractStreet‐level organizations (SLOs) play a key, but understudied, political role in democratic governance as they are responsible for the direct‐delivery of public services that are vital to the functioning of the state. To discuss the political role of SLOs in general, this study begins by identifying four SLO roles, which are conceptualized here by distinguishing policy‐sphere versus politics‐sphere and “SLOs‐as‐takers” versus “SLOs‐as‐makers.” SLOs' political role in a democratic backsliding and populism context is specified by distinguishing whether SLOs converge to, or diverge from, illiberal policies, and distinguishing reactive and proactive responses. Each of the four responses is elaborated by referring to how SLOs both influence, and are influenced by, populism and democratic backsliding. Shifting attention to the specific context of democratic erosion allows a more nuanced distinction between policy sectors and countries, as well as identifying the ways through which public service provision facilitates or inhibits democratic backsliding.
The visibility paradox: Impediment or benefit to vicarious learning in hybrid work environments?
Authors: Benabid Myriam , Abdalla Mikhaeil Christine 
Published: July 2024

AbstractOrganisations have increasingly adopted enterprise social networks to mitigate the challenges of hybrid work environments for workplace learning, particularly vicarious learning. However, the improved communication visibility intended to facilitate vicarious learning may paradoxically create tensions that could potentially undermine the benefits of communication visibility, recreating the invisibility of knowledge work. Through an in‐depth single qualitative case study at one of the Big Four consulting firms, which serves as a paradigmatic case for hybrid work, we explain how the visibility enabled by enterprise social networks can alleviate or impede vicarious learning in hybrid work environments. We identify three instances of the visibility paradox—performance, information overload, and availability—that create a burden on both knowledge sources and seekers. Consequently, their individual strategic responses render knowledge work invisible, thereby preventing third‐parties from capitalising on the potential benefits of vicarious learning that an enterprise social network could afford.