bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningkatkan Kemampuan Membaca Permulaan Anak Usia 5-6 Tahun Menggunakan Media Papan Bingo
Authors: Syafira Zakiah , Anesty Mashudi Esya , Nenden Sundari 
Published: August 2024

Tujuan penelitian ini untuk meningkatkan kemampuan membaca permulaan anak-anak usia 5-6 tahun di TK Aisyiyah Bustanul Athfal 3 dengan menggunakan Media Papan Bingo. Penelitian ini menggunakan pendekatan Penelitian Tindakan Kelas (PTK) berdasarkan kerangka kerja Kemmis dan MC Taggart. Subjek penelitian ini terdiri dari 10 siswa kelas B. Observasi, wawancara, dan dokumentas adalah cara yang digunakan untuk memperoleh data. Kemudian dianalisis menggunakan teknik analisis data kualitatif yang meliputi tahap reduksi, display, dan generalisasi. Penelitian ini terdiri dari dua siklus, masing-masing melalui empat tahap: perencanaan, pelaksanaan, pengamatan, dan refleksi. Setiap siklus menggunakan tema yang berbeda, yaitu "Alam Semesta" pada siklus pertama dan "Gema Ramadhan" pada siklus kedua. Hasil penelitian menunjukkan adanya peningkatan kemampuan membaca permulaanl pada anak-anak. Persentase siswa yang mencapai kategori BSH dan BSB meningkat dari siklus ke siklus. Setiap indikator kemampuan membaca permulaan juga mengalami peningkatan yang melampaui target ketercapaian yang ditetapkan. Dengan demikian, media ini dapat menjadi alternatif bagi pendidik dalam meningkatkan kemampuan membaca permulaan anak-anak usia 5-6 tahun.
Pemanfaatan Media Loose Part dalam Pembelajaran Literasi dan Sosial Emosional Anak Usia Dini
Authors: Utamimah Sri , Samawi Ahmad , Arifin Imron , Pramono Pramono , Nur Aisyah Eny , Putri Pratiwi Ajeng 
Published: August 2024

Anak usia dini merupakan masa golden age, yaitu masa perkembangan yang sangat pesat. Perkembangan yang perlu dikembangkan pada masa ini adalah kognitif, psikomotorik, dan perilaku sosial. Oleh sebab itu peneliti tertarik untuk melakukan penelitian tentang pemanfaatan media loose part dalam pembelajaran anak usia dini yang bertujuan untuk mengembangkan perkembangan literasi dan sosial emosional anak. Pembelajaran yang dikembangkan pengembangan literasi (pengenalan huruf, angka dan kata) dengan menggunakan media yang ada disekitarnya tanpa memberikan kesan belajar dan calistung pada anak usia dini. Penelitian ini menerapkan pendekatan penelitian deskriptif kualitatif, subjek penelitian di semua rombel dengan 3-4 anak disetiap rombel dari usia 4-6 Tahun. Sumber data yang peneliti kumpulkan guru dan wali murid. Data yang dikumpulkan melalui wawancara dan dokumentasi kemudian dianalisis menggunakan triangulasi data sesuai Model Miles dan Huberman. Hasil penelitian menyimpulkan pengembangan literasi sendiri dapat dilihat pada kemampuan anak meniru menyebutkan dan menulis huruf pada media loosepart yang disediakan oleh guru dan kemampuan menyebutkan benda yang baru. Pengembangan sosial emosional anak juga muncul dalam pemanfaatan media tersebut, seperti kegiatan bermain bersama, mampu bekerja sama dengan baik, mau berbagi, sabar menunggu giliran, mendemonstrasikan kegiatan yang dilakukan didepan kelas.
Kinetic Family Drawing: Persepsi Anak Fatherless di Panti Asuhan Terhadap Sosok Ayah
Authors: Hayatunnufus Alissa , Ratri Dianing 
Published: August 2024

Penelitian ini bertujuan untuk mengungkap persepsi anak fatherless yang tinggal di panti asuhan terhadap sosok ayah dalam keluarga. Hilangnya sosok ayah bagi anak, menyebabkan banyak permasalahan dan dampak buruk terhadap tumbuh kembang anak. Panti asuhan sejatinya memberikan wadah sebagai keluarga baru dan pengasuh sebagai ganti peran orang tua yang hilang dalam hidup anak. Namun, perancangan sistem pola asuh anak harus sejalan dengan kebutuhan anak, yaitu melalui ungkapan persepsi mereka terhadap sosok ayahnya. Metode yang digunakan adalah kualitatif deskriptif dengan pendekatan fenomenologi, melalui proses komunikasi visual anak berupa gambar bertema “keluarga”. Pesertanya adalah anak usia dini dengan rentang 6-8 tahun, latar belakang fatherless yang tinggal di suatu panti asuhan. Gambar anak tersebut kemudian dianalisis menggunakan teori Kinetic Family Drawing (KFD) oleh Kaufman (1970) yang dikembangkan lagi oleh Zlateva (2019). Hasil dari penelitian ini, ditemukan bahwa anak masih menganngap sosok ayah ada di luar sana, dan bukan pengasuh di panti asuhan. Ayah dianggap sebagai seseorang di dalam anggota keluarga yang cukup jauh jaraknya dengan anak-anak, ayah merupakan orang tua yang tidak dominan dalam keluarganya.
Peran Guru dalam Mereduksi Perilaku Agresif Anak di Sekolah
Authors: Kwartie Risa , Fitriani Yulianti , Nuroniah Pepi 
Published: August 2024

Anak usia dini belum dapat sepenuhnya mengontrol emosi pada dirinya sendiri. Salah satu perilaku yang muncul dikalangan anak yaitu perilaku agresif. Guru berperan penting dalam mereduksi perilaku agresif anak di sekolah. Hal itulah yang menjadi tujuan utama dalam penelitian ini yang akan di fokuskan disalah satu Taman Kanak-Kanak. Penelitian ini menggunakan metode pendekatan kualitatif dengan model studi kasus. Teknik pengumpulan data yang digunakan terdiri dari observasi, wawancara dan dokumentasi. Subjek pada penelitian yakni dua orang guru di salah satu TK di Kota Serang. Teknis analisis data pada penelitian ini yaitu reduksi data, penyajian data, penarikan kesimpulan. Berdasarkan hasil penelitian peran guru di salah satu TK di Kota Serang dalam mereduksi perilaku agresif anak pada aspek 1)Pengetahuan guru tentang perilaku agresif dimana guru memiliki pemahaman mengenai pengertian, bentuk, dan faktor penyebab perilaku agresif. 2)Upaya guru dalam mereduksi perilaku agresif diantaranya guru menjadi role model yang baik untuk anak, membatasi tontonan/bacaan yang mengandung unsur kekerasan, dan melalukan kegiatan membentuk kemampuan berempati. 3)Intervensi yang dilakukan guru yaitu melakukan metode bermain peran, membantu anak menyalurkan energinya, dan memberikan hukuman pada anak berperilaku agresif. Oleh karena itu hasil penelitian ini dapat direkomendasikan kepada guru atau sekolah dalam hal mereduksi perilaku agresif pada anak usia dini.
Dead or alive: the effect of shells and living individuals of Sinanodonta woodiana (Lea, 1834) on habitat selection and behaviour of European unionid bivalves
Authors: Wiśniewski Kamil , Szarmach Daniel , Kobak Jarosław , Kakareko Tomasz , Jermacz Łukasz , Poznańska-Kakareko Małgorzata 
Published: August 2024

1. Ecosystem engineering freshwater bivalves, burrowing in the substratum and accumulating shell deposits, transform bottom habitats. Especially the invasive Asian bivalve Sinanodonta woodiana (SW), due to its rapid growth, large size, and high fecundity, can affect benthic communities. Here, we determined its effect on habitat selection and behaviour of endangered native bivalves, Anodonta cygnea and Unio tumidus.
2. We conducted laboratory preference assays (Experiment 1: choice between two substrata) exposing the native bivalves to pure sand (control), shells (several densities on the sand surface or burrowed), or living SW. Then, we tested their locomotion and burrowing (Experiment 2) on pure sand and substrata contaminated with shells or living SW.
3. In Experiment 1, native bivalves avoided shells, but not living SW. Burrowed and larger shells were avoided compared with those on the surface and smaller ones, respectively.
4. In Experiment 2, U. tumidus exposed to SW delayed activity initiation (in response to living bivalves), increased locomotion (living bivalves, surface shells), and reduced burrowing depth (living bivalves, all shells). Anodonta cygnea exposed to SW reduced locomotion speed (living bivalves, shells), and reduced burrowing duration (burrowed shells) and depth (living bivalves, burrowed shells).
5. SW (especially shell beds) constitutes another emerging threat to native bivalves, impairing their burrowing and inducting active avoidance. As SW expands its distribution with climate warming, the range and strength of its impact is likely to increase, reducing the area available to native bivalves, exposing them to environmental dangers (due to burrowing limitation) and deteriorating physical condition (energetic resources used for excessive locomotion).
Regulatory T Cell Insufficiency in Autoimmune Diabetes Is Driven by Selective Loss of Neuropilin-1 on Intraislet Regulatory T Cells
Authors: Grebinoski Stephanie , Pieklo Gwenyth , Zhang Qianxia , Visperas Anabelle , Cui Jian , Goulet Jordana , Xiao Hanxi , Brunazzi Erin A , Cardello Carly , Herrada Andrés A , Das Jishnu , Workman Creg J , Vignali Dario A A 
Published: August 2024

Abstract
Approaches to reverse or limit regulatory T cell (Treg) insufficiency are of great interest for development of immunotherapeutic treatments for autoimmune patients, including type 1 diabetes. Treg insufficiency is heavily implicated in the progression of autoimmune diabetes in the NOD mouse model and is characterized by defects in Treg numbers, development, and/or function. Utilizing a Treg-centric screen, we show that intraislet Tregs have a uniquely dysfunctional phenotype, hallmarked by an almost complete lack of neuropilin-1 (Nrp1), a cell surface receptor required to maintain Treg stability. Intraislet Nrp1– Tregs exhibit hallmark features of fragility, including reduced suppressive capacity, decreased CD73 and Helios, and increased Rorγt and Tbet. Intraislet Nrp1– Tregs also exhibit decreased Foxp3 expression on a per cell basis, suggesting that Nrp1 may also be required for long-term Treg stability. Mechanistically, Treg-restricted augmentation of Nrp1 expression limited the onset of autoimmune diabetes in NOD mice suggesting that Nrp1 critically impacts intraislet Treg function. Transcriptional analysis showed that Nrp1 restoration led to an increase in markers and pathways of TCR signaling, survival, and suppression, and when Nrp1 protein expression is examined by cellular indexing of transcriptomes and epitopes by sequencing, significant differences were observed between Nrp1+ and Nrp1– Tregs in all tissues, particularly in markers of Treg fragility. This translated into substantive differences between Nrp1+ and Nrp1– Tregs that afforded the former with a competitive advantage in the islets. Taken together, these data suggest that maintenance of Nrp1 expression and signaling on Tregs limits diabetes onset and may serve as a strategy to combat Treg insufficiency in autoimmune disease.
Evaluation of Schneiderian First-rank Symptoms in Patients of Psychosis Attending a Tertiary Care Center from North India
Authors: Jain Aditi , Mehdi Abbas 
Published: August 2024

Abstract

Background:
The Schneiderian first-rank symptoms (SFRS) have played an extremely important role in the diagnostic systems in psychiatry. However, all studies do not seem to support Schneider’s claim that FRS confer a clear indication of schizophrenia when no organic syndrome is present.

Objectives:
The objectives of this study were as follows: (1) to examine the presence of SFRS in untreated cases of psychosis, (2) to see the degree of improvement in SFRS with treatment over 12 weeks of short-term follow-up, (3) to see correlation of SFRS with sociodemographic and clinical parameters in our patients, and (4) to see the correlation of SFRS among diagnostic subgroups in our patients.

Materials and Methods:
Setting: Psychiatry department of a multi specialty tertiary care center in North India.

Study Design:
This was a short-term prospective study. After taking ethical clearance from the institutional ethics committee and written informed consent from all the patients, data sets were prepared for 60 patients of untreated psychosis. Data analysis was done using the SPSS version 20.0.

Results:
Voices discussing (83.33%) and voices commenting (80%) were the most commonly noted SFRS, and the mean number of SFRS in our sample was 3.34. Somatic passivity (f = 10.80, P = 0.0001) and thought insertion (f = 6.75 and P = 0.004) could significantly differentiate between schizophrenia and other diagnostic subgroups of untreated psychosis in our study.

Conclusions:
Only somatic passivity, delusional perception, and thought insertion were extremely specific in distinguishing the patients of schizophrenia from nonschizophrenic patients.
Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer: A single center experience
Authors: Gao Zhao , Jin Xuan , Wu Ying-Chao , Zhang Shi-Jie , Wu Shi-Kai , Wang Xin 
Published: August 2024

BACKGROUND
Numerous studies have assessed surgical resection as a standard treatment option for patients with colorectal cancer (CRC) and resectable pulmonary metastases (PM). However, the role of perioperative chemotherapy after complete resection of isolated PM from patients with CRC patients remains controversial. We hypothesize that perioperative chemotherapy does not provide significant survival benefits for patients undergoing resection of PM from CRC.
AIM
To determine whether perioperative chemotherapy affects survival after radical resection of isolated PM from CRC.
METHODS
We retrospectively collected demographic, clinical, and pathologic data on patients who underwent radical surgery for isolated PM from CRC. Cancer-specific survival (CSS) and disease-free survival were calculated using Kaplan-Meier analysis. Inter-group differences were compared using the log-rank test. For multivariate analysis, Cox regression was utilized when indicated.
RESULTS
This study included 120 patients with a median age of 61.6 years. The 5-year CSS rate was 78.2%, with 36.7% experiencing recurrence. Surgical resection for isolated PM resulted in a 5-year CSS rate of 50.0% for second metastases. Perioperative chemotherapy (P = 0.079) did not enhance survival post-resection. Factors associated with improved survival included fewer metastatic lesions [hazard ratio (HR): 2.51, P = 0.045], longer disease-free intervals (HR: 0.35, P = 0.016), and wedge lung resections (HR: 0.42, P = 0.035). Multiple PM predicted higher recurrence risk (HR: 2.22, P = 0.022). The log-rank test showed no significant difference in CSS between single and repeated metastasectomy (P = 0.92).
CONCLUSION
Perioperative chemotherapy shows no survival benefit post-PM resection in CRC. Disease-free intervals and fewer metastatic lesions predict better survival. Repeated metastasectomy is warranted for eligible patients.
Camrelizumab, apatinib and hepatic artery infusion chemotherapy combined with microwave ablation for advanced hepatocellular carcinoma
Authors: Zuo Meng-Xuan , An Chao , Cao Yu-Zhe , Pan Jia-Yu , Xie Lu-Ping , Yang Xin-Jing , Li Wang , Wu Pei-Hong 
Published: August 2024

BACKGROUND
Hepatic arterial infusion chemotherapy and camrelizumab plus apatinib (TRIPLET protocol) is promising for advanced hepatocellular carcinoma (Ad-HCC). However, the usefulness of microwave ablation (MWA) after TRIPLET is still controversial.
AIM
To compare the efficacy and safety of TRIPLET alone (T-A) vs TRIPLET-MWA (T-M) for Ad-HCC.
METHODS
From January 2018 to March 2022, 217 Ad-HCC patients were retrospectively enrolled. Among them, 122 were included in the T-A group, and 95 were included in the T-M group. A propensity score matching (PSM) was applied to balance bias. Overall survival (OS) was compared using the Kaplan-Meier curve with the log-rank test. The overall objective response rate (ORR) and major complications were also assessed.
RESULTS
After PSM, 82 patients were included both the T-A group and the T-M group. The ORR (85.4%) in the T-M group was significantly higher than that (65.9%) in the T-A group (P < 0.001). The cumulative 1-, 2-, and 3-year OS rates were 98.7%, 93.4%, and 82.0% in the T-M group and 85.1%, 63.1%, and 55.0% in the T-A group (hazard ratio = 0.22; 95% confidence interval: 0.10-0.49; P < 0.001). The incidence of major complications was 4.9% (6/122) in the T-A group and 5.3% (5/95) in the T-M group, which were not significantly different (P = 1.000).
CONCLUSION
T-M can provide better survival outcomes and comparable safety for Ad-HCC than T-A.
Combining lymph node ratio to develop prognostic models for postoperative gastric neuroendocrine neoplasm patients
Authors: Liu Wen , Wu Hong-Yu , Lin Jia-Xi , Qu Shu-Ting , Gu Yi-Jie , Zhu Jin-Zhou , Xu Chun-Fang 
Published: August 2024

BACKGROUND
Lymph node ratio (LNR) was demonstrated to play a crucial role in the prognosis of many tumors. However, research concerning the prognostic value of LNR in postoperative gastric neuroendocrine neoplasm (NEN) patients was limited.
AIM
To explore the prognostic value of LNR in postoperative gastric NEN patients and to combine LNR to develop prognostic models.
METHODS
A total of 286 patients from the Surveillance, Epidemiology, and End Results database were divided into the training set and validation set at a ratio of 8:2. 92 patients from the First Affiliated Hospital of Soochow University in China were designated as a test set. Cox regression analysis was used to explore the relationship between LNR and disease-specific survival (DSS) of gastric NEN patients. Random survival forest (RSF) algorithm and Cox proportional hazards (CoxPH) analysis were applied to develop models to predict DSS respectively, and compared with the 8th edition American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging.
RESULTS
Multivariate analyses indicated that LNR was an independent prognostic factor for postoperative gastric NEN patients and a higher LNR was accompanied by a higher risk of death. The RSF model exhibited the best performance in predicting DSS, with the C-index in the test set being 0.769 [95% confidence interval (CI): 0.691-0.846] outperforming the CoxPH model (0.744, 95%CI: 0.665-0.822) and the 8th edition AJCC TNM staging (0.723, 95%CI: 0.613-0.833). The calibration curves and decision curve analysis (DCA) demonstrated the RSF model had good calibration and clinical benefits. Furthermore, the RSF model could perform risk stratification and individual prognosis prediction effectively.
CONCLUSION
A higher LNR indicated a lower DSS in postoperative gastric NEN patients. The RSF model outperformed the CoxPH model and the 8th edition AJCC TNM staging in the test set, showing potential in clinical practice.
Endoscopic detection and diagnostic strategies for minute gastric cancer: A real-world observational study
Authors: Ji Xiao-Wei , Lin Jie , Wang Yan-Ting , Ruan Jing-Jing , Xu Jing-Hong , Song Kai , Mao Jian-Shan 
Published: August 2024

BACKGROUND
Minute gastric cancers (MGCs) have a favorable prognosis, but they are too small to be detected by endoscopy, with a maximum diameter ≤ 5 mm.
AIM
To explore endoscopic detection and diagnostic strategies for MGCs.
METHODS
This was a real-world observational study. The endoscopic and clinicopathological parameters of 191 MGCs between January 2015 and December 2022 were retrospectively analyzed. Endoscopic discoverable opportunity and typical neoplastic features were emphatically reviewed.
RESULTS
All MGCs in our study were of a single pathological type, 97.38% (186/191) of which were differentiated-type tumors. White light endoscopy (WLE) detected 84.29% (161/191) of MGCs, and the most common morphology of MGCs found by WLE was protruding. Narrow-band imaging (NBI) secondary observation detected 14.14% (27/191) of MGCs, and the most common morphology of MGCs found by NBI was flat. Another three MGCs were detected by indigo carmine third observation. If a well-demarcated border lesion exhibited a typical neoplastic color, such as yellowish-red or whitish under WLE and brownish under NBI, MGCs should be diagnosed. The proportion with high diagnostic confidence by magnifying endoscopy with NBI (ME-NBI) was significantly higher than the proportion with low diagnostic confidence and the only visible groups (94.19% > 56.92% > 32.50%, P < 0.001).
CONCLUSION
WLE combined with NBI and indigo carmine are helpful for detection of MGCs. A clear demarcation line combined with a typical neoplastic color using nonmagnifying observation is sufficient for diagnosis of MGCs. ME-NBI improves the endoscopic diagnostic confidence of MGCs.
Curcumin for gastric cancer: Mechanism prediction via network pharmacology, docking, and in vitro experiments
Authors: Yang Peng-Hui , Wei Ya-Nan , Xiao Bi-Juan , Li Si-Yi , Li Xin-Long , Yang Liang-Jun , Pan Hua-Feng , Chen Geng-Xin 
Published: August 2024

BACKGROUND
Curcumin originates from the natural herb turmeric, and its antitumor effects have been known about for a long time. However, the mechanism by which curcumin affects gastric cancer (GC) has not been elucidated.
AIM
To elucidate the potential mechanisms of curcumin in the treatment of GC.
METHODS
Network pharmacological approaches were used to perform network analysis of Curcumin. We first analyzed Lipinski’s Rule of Five for the use of Curcumin. Curcumin latent targets were predicted using the PharmMapper, SwissTargetPrediction and DrugBank network databases. GC disease targets were mined through the GeneCard, OMIM, DrugBank and TTD network databases. Then, GO enrichment, KEGG enrichment, protein-protein interaction (PPI), and overall survival analyses were performed. The results were further verified through molecular docking, differential expression analysis and cell experiments.
RESULTS
We identified a total of 48 curcumin-related genes with 31 overlapping GC-related targets. The intersection targets between curcumin and GC have been enriched in 81 GO biological processes and 22 significant pathways. Following PPI analysis, 6 hub targets were identified, namely, estrogen receptor 1 (ESR1 ), epidermal growth factor receptor (EGFR ), cytochrome P450 family 3 subfamily A member 4 (CYP3A4 ), mitogen-activated protein kinase 14 (MAPK14 ), cytochrome P450 family 1 subfamily A member 2 (CYP1A2 ), and cytochrome p450 family 2 subfamily B member 6 (CYP2B6 ). These factors are correlated with decreased survival rates among patients diagnosed with GC. Molecular docking analysis further substantiated the strong binding interactions between Curcumin and the hub target genes. The experimental findings demonstrated that curcumin not only effectively inhibits the growth of BGC-823 cells but also suppresses their proliferation. mRNA levels of hub targets CYP3A4 , MAPK14 , CYP1A2 , and CYP2B6 in BGC-823 cells were significantly increased in each dose group.
CONCLUSION
Curcumin can play an anti-GC role through a variety of targets, pathways and biological processes.