bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and feasibility of integrating personalized PRO dashboards into prostate cancer care
Authors: Hartzler Andrea L , Izard Jason P , Dalkin Bruce L , Mikles Sean P , Gore John L 
Published: August 2015

Abstract
Objective Patient-reported outcomes (PROs) are a valued source of health information, but prior work focuses largely on data capture without guidance on visual displays that promote effective PRO use in patient-centered care. We engaged patients, providers, and design experts in human-centered design of “PRO dashboards” that illustrate trends in health-related quality of life (HRQOL) reported by patients following prostate cancer treatment.
Materials and Methods We designed and assessed the feasibility of integrating dashboards into care in 3 steps: (1) capture PRO needs of patients and providers through focus groups and interviews; (2) iteratively build and refine a prototype dashboard; and (3) pilot test dashboards with patients and their provider during follow-up care.
Results Focus groups ( n = 60 patients) prioritized needs for dashboards that compared longitudinal trends in patients’ HRQOL with “men like me.” Of the candidate dashboard designs, 50 patients and 50 providers rated pictographs less helpful than bar charts, line graphs, or tables ( P &lt; .001) and preferred bar charts and line graphs most. Given these needs and the design recommendations from our Patient Advisory Board ( n = 7) and design experts ( n = 7), we built and refined a prototype that charts patients’ HRQOL compared with age- and treatment-matched patients in personalized dashboards. Pilot testing dashboard use ( n = 12 patients) improved compliance with quality indicators for prostate cancer care ( P &lt; .01).
Conclusion PRO dashboards are a promising approach for integrating patient-generated data into prostate cancer care. Informed by human-centered design principles, this work establishes guidance on dashboard content, tailoring, and clinical use that patients and providers find meaningful.
Diagnosing psychiatric disorders in people with intellectual disabilities: issues and achievements
Authors: Bertelli Marco O. , Rossi Michele , Scuticchio Daniela , Bianco Annamaria 
Published: August 2015

Purpose
– Diagnosing psychiatric disorders (PD) in adults with Intellectual Disability (ID) presents several issues and need specific skills and tools. The purpose of this paper is to provide a detailed description of the current status of art through a systematic mapping of the literature.

Design/methodology/approach
– The authors reviewed the international literature on the basis of the following questions: what are the issues in the psychiatric diagnostic process for adults with ID? What methods and procedures have been used for psychiatric assessment in ID? To date, is it possible to identify some most effective procedures?

Findings
– The analysis of the literature indicates that main issues of the psychiatric diagnostic process in adults with ID are the following: identification of psychiatric symptoms, behavioural equivalents, diagnostic criteria, setting, source of information, screening, and diagnostic tools. The evidence base is only emerging and although many relevant achievements have been reached in the last two decades, no definitive guideline has been produced. Most recent acquisition also allowed to identify some assessment procedures that are currently considered the most effective. Individualised assessment remains the best way to meet the needs of this heterogeneous and variable patient group.

Originality/value
– This paper offers a comprehensive and updated description of current achievements and issues towards the assessment of PD in people with ID.
Mental health and intellectual disability: integrating different approaches in the neurodevelopmental perspective
Authors: Bertelli Marco O. 
Published: August 2015

Purpose– The purpose of this paper is to provide a critical overview of some main implications of the neurodevelopmental perspective for the field of the mental health in intellectual disability and autism spectrum disorders.Design/methodology/approach– A discussion surrounding the importance of integrating different approaches in the neurodevelopmental perspective, drawing on sources from the paper proposals to the 10th International Congress of the European Association in Mental Health and Intellectual Disability (EAMHID), and the literature.Findings– At present, the neurodevelopmental perspective seems to be the most appropriate and valued conceptual framework to support multi-level, interdisciplinary approaches in understanding the aetiologies of mental health problems as well as when and how to intervene. It inherently exemplifies a dimensional approach, which can capture variations between individuals, their developmental time course, brain-behaviours associations and functional significance better than categorical approaches, and diagnostic measures.Originality/value– This editorial outlines a special issue that offers a comprehensive and varied collection of papers from the contributions to the 10th International Congress of the EAMHID.
Homogenization of selective laser melting cellular material for impact performance simulation
Authors: Labeas G. , Ptochos Evangelos 
Published: August 2015

Purpose
– The purpose of this paper is to present, the global behaviour of sandwich structures comprising cellular cores is predicted by finite element (FE) analysis. Two modelling approaches are investigated, providing different levels of accuracy; in both approaches, the sandwich structure is idealised as a layered stack with the skin modelled using shell elements; while the core is either modelled with fine detail using beam micro-elements representing the cell struts, or is modelled by three-dimensional solid elements after an appropriate core homogenisation.

Design/methodology/approach
– The applied homogenisation methodology, as well as the all important modelling issues are presented in detail. Experimental tests performed using a mass-drop testing machine are used for the successful validation of the simulation models.

Findings
– It was concluded that the core microscale models having detailed FE modelling of the core unit cells geometry with fine scale beam elements are suitable for the analysis of the core failure modes and the prediction of the basic core stiffness and strength properties. It was demonstrated that the homogenised core model provides significant advantages with respect to computing time and cost, although they require additional calculations in order to define the homogenised stress-strain curves.

Research limitations/implications
– Special microscale material tests are required for the determination of appropriate materials parameters of the core models, as steel selective laser melting (SLM) microstrut properties differ from the constitutive steel material ones, due to the core manufacturing SLM technique. Stress interactions were not taken into account in the homogenisation, as the applied core material model supports the introduction of independent stress-strain curves; however, the predicted load deflection results appeared to be very close to those obtained from the detailed core micromodels.

Originality/value
– The paper is original. The dynamic behaviour of conventional sandwich structures comprising conventional honeycomb type cores has been extensively studied, using simple mass-spring models, energy based models, as well as FE models. However, the response of sandwich panels with innovative SLM cellular cores has been limited. In the present paper, novel modelling approaches for the simulation of the structural response of sandwich panels having innovative open lattice cellular cores produced by SLM are investigated.
A global reference for caesarean section rates (C‐Model): a multicountry cross‐sectional study
Authors: Souza JP , Betran AP , Dumont A , de Mucio B , Gibbs Pickens CM , Deneux‐Tharaux C , Ortiz‐Panozo E , Sullivan E , Ota E , Togoobaatar G , Carroli G , Knight H , Zhang J , Cecatti JG , Vogel JP , Jayaratne K , Leal MC , Gissler M , Morisaki N , Lack N , Oladapo OT , Tunçalp Ö , Lumbiganon P , Mori R , Quintana S , Costa Passos AD , Marcolin AC , Zongo A , Blondel B , Hernández B , Hogue CJ , Prunet C , Landman C , Ochir C , Cuesta C , Pileggi‐Castro C , Walker D , Alves D , Abalos E , Moises ECD , Vieira EM , Duarte G , Perdona G , Gurol‐Urganci I , Takahiko K , Moscovici L , Campodonico L , Oliveira‐Ciabati L , Laopaiboon M , Danansuriya M , Nakamura‐Pereira M , Costa ML , Torloni MR , Kramer MR , Borges P , Olkhanud PB , Pérez‐Cuevas R , Agampodi SB , Mittal S , Serruya S , Bataglia V , Li Z , Temmerman M , Gülmezoglu AM 
Published: August 2015

ObjectiveTo generate a global reference for caesarean section (CS) rates at health facilities.DesignCross‐sectional study.SettingHealth facilities from 43 countries.Population/SampleThirty eight thousand three hundred and twenty‐four women giving birth from 22 countries for model building and 10 045 875 women giving birth from 43 countries for model testing.MethodsWe hypothesised that mathematical models could determine the relationship between clinical‐obstetric characteristics and CS. These models generated probabilities of CS that could be compared with the observed CS rates. We devised a three‐step approach to generate the global benchmark of CS rates at health facilities: creation of a multi‐country reference population, building mathematical models, and testing these models.Main outcome measuresArea under the ROC curves, diagnostic odds ratio, expected CS rate, observed CS rate.ResultsAccording to the different versions of the model, areas under the ROC curves suggested a good discriminatory capacity of C‐Model, with summary estimates ranging from 0.832 to 0.844. The C‐Model was able to generate expected CS rates adjusted for the case‐mix of the obstetric population. We have also prepared an e‐calculator to facilitate use of C‐Model (www.who.int/reproductivehealth/publications/maternal_perinatal_health/c-model/en/).ConclusionsThis article describes the development of a global reference for CS rates. Based on maternal characteristics, this tool was able to generate an individualised expected CS rate for health facilities or groups of health facilities. With C‐Model, obstetric teams, health system managers, health facilities, health insurance companies, and governments can produce a customised reference CS rate for assessing use (and overuse) of CS.Tweetable abstractThe C‐Model provides a customized benchmark for caesarean section rates in health facilities and systems.
The Use of Entheseal Changes in the Femur and Os Coxa for Age Assessment
Authors: Listi Ginesse A. 
Published: August 2015

AbstractThis study examined the relationship between age and entheseal modifications in the femur and os coxa for estimating age at death. Five areas on the os coxa and four on the femur were scored in 200 white individuals over 40 years of age. Statistical analyses assessed the relationship between age and entheseal modification using both raw scores and scores adjusted for body size, for each sex, and for sexes combined. Results indicate that significant relationships exist between age and entheseal modification at three sites on the femur and four on the os coxae, but the relationships are not strong enough to generate age predictions. Conversely, the most severe entheseal modifications show promise as an indicator of age in older adults. Although further research is needed using larger samples for robust statistical analyses, current data indicate these modifications can suggest an age >60, or in some cases 70, years.
Efficacy and safety results from a Phase 3, randomized, placebo‐controlled trial of subcutaneous golimumab in Chinese patients with active rheumatoid arthritis despite methotrexate therapy
Authors: Li Zhanguo , Zhang Fengchun , Kay Jonathan , Fei Kaiyin , Han Chenglong , Zhuang Yanli , Wu Zhong , Hsia Elizabeth C. 
Published: August 2015

AbstractAimThe efficacy and safety of golimumab + methotrexate (MTX) were evaluated in Chinese patients with active rheumatoid arthritis (RA) despite MTX therapy.MethodsChinese patients (n = 264) were randomly assigned (1 : 1) to receive subcutaneous injections of placebo + MTX with crossover to golimumab 50 mg + MTX at week 24 (Group 1) or to golimumab 50 mg + MTX (Group 2) every 4 weeks. Group 1 patients with inadequate response entered blinded early escape to golimumab 50 mg + MTX at week 16. At least a 20% improvement in the American College of Rheumatology (ACR20) criteria at week 14 was the primary endpoint. Other assessments included the 28‐joint count Disease Activity Score using C‐reactive protein (DAS28‐CRP) and Health Assessment Questionnaire‐Disability Index (HAQ‐DI) through week 52. Adverse events (AEs) were monitored through week 56.ResultsACR20 response at week 14 was significantly higher in Group 2 (40.9% [54/132]) compared with Group 1 (15.9% [21/132]; P < 0.001). Greater proportions of patients in Group 2 compared with Group 1 had a DAS28‐CRP response at week 14 (65.2% vs. 30.3%, P < 0.001) or ACR20 response at week 24 (42.4% vs. 15.9%, P < 0.001), and Group 2 had a significantly greater change in HAQ‐DI at week 24 (−0.26 vs. 0.15, P < 0.001). After week 24, the proportion of patients achieving ACR20 in Group 1 approached that in Group 2. Through week 16, 23.5% of Group 1 and 26.7% of Group 2 patients reported AEs. Among golimumab + MTX‐treated patients, 50.2% and 4.2% had ≥ 1 AE or serious AE, respectively, through week 56. No unexpected safety signals were observed.ConclusionAmong MTX‐experienced Chinese patients with active RA, a significantly greater proportion of patients receiving golimumab + MTX had improvements in the signs and symptoms of RA compared with MTX monotherapy. Safety findings were consistent with previous studies of golimumab in patients with RA.
Protection of farmed camels (Camelus Dromedarius): Welfare problems and legislative perspective
Authors: Previti Annalisa , Guercio Bartolomeo , Passantino Annamaria 
Published: August 2015

AbstractIn the last years animal welfare has assumed an increasing interest in our society, influencing legislation to enact many provisions aimed at the protection of animals. Along with increased consumer awareness of the need to maintain ethically acceptable conditions of raised animals, scientists too have begun to investigate the conditions of animal welfare, the tools for its evaluation and for its improvement. Although there are many advances in knowledge, much remains to be investigated concerning many species considered "minor", that is, camels and dromedaries. Dromedaries, recently, have attracted the interest of some breeders following the results of studies concerning the nutritional and therapeutic properties of their products ‐ milk in particular ‐ that make them ideal for some particular categories of consumers, such as diabetics, obesity sufferers, lactose‐intolerant subjects, menopausal women and so on. Considering their use in dairy husbandry, dromedaries are reared under intensive and/or semi‐intensive systems with the resulting emergence of specific needs, which should be fulfilled in order to have appropriate welfare. This paper's purpose is to give practical elements in order to find out dromedary welfare standards, promoting a comprehensive set of regulations on welfare, care and protection of this animal.
Laparoscopic and open right‐sided colonic resection in daily routine practice. A prospective multicentre study within an Enhanced Recovery After Surgery (ERAS) protocol
Authors: Tiefenthal M. , Asklid D. , Hjern F. , Matthiessen P. , Gustafsson U. O. 
Published: August 2015

AbstractAimThe study compared the outcome of laparoscopic and open surgery in daily practice when performed in a strict Enhanced Recovery After Surgery (ERAS) environment.MethodTwo‐hundred and ninety‐two consecutive patients who received elective surgery, in three Swedish ERAS centres, for cancer or adenoma in the right colon in the period 1 January 2011 to 31 December 2012, were prospectively registered in a Web‐based ERAS database. Peri‐operative data were collected from the database and patient charts. The primary end‐points included postoperative recovery and morbidity. The secondary objective was to identify preoperative variables that influenced the selection of patients for laparoscopic or open surgery.ResultsOne‐hundred and twenty‐three (42%) patients were selected for laparoscopic surgery. The overall preoperative ERAS‐compliance rate was 87% and no significant difference was seen between the surgical techniques. In multivariate analysis, patients treated with laparoscopy had significantly earlier pain control (2.4 ± 3.2 days vs 4.2 ± 5.9 days; P = 0.016) and a shorter length of hospital stay (LOS) (4 days vs 6 days; P = 0.002) compared with open surgery. There was no significant difference in the complication rate [18.7% vs 21.3%; OR = 1.0 (95% CI: 0.5–2.0)], the number of lymph nodes removed or the rate of R0 resection between laparoscopic and open surgery. Tumours selected for laparoscopy were generally smaller, had a lower T‐stage and were predominantly situated in the caecum and the ascending colon compared with those of patients selected for open surgery.ConclusionThe use of laparoscopy in routine right‐sided colectomy in an ERAS environment, with data on outcome corrected for selection bias, may result in faster recovery compared with open surgery.
The irreversibility of sensitive period effects in language development: evidence from second language acquisition in international adoptees
Authors: Norrman Gunnar , Bylund Emanuel 
Published: August 2015

AbstractThe question of a sensitive period in language acquisition has been subject to extensive research and debate for more than half a century. While it has been well established that the ability to learn new languages declines in early years, the extent to which this outcome depends on biological maturation in contrast to previously acquired knowledge remains disputed. In the present study, we addressed this question by examining phonetic discriminatory abilities in early second language (L2) speakers of Swedish, who had either maintained their first language (L1) (immigrants) or had lost it (international adoptees), using native speaker controls. Through this design, we sought to disentangle the effects of the maturational state of the learner on L2 development from the effects of L1 interference: if additional language development is indeed constrained by an interfering L1, then adoptees should outperform immigrant speakers. The results of an auditory lexical decision task, in which fine vowel distinctions in Swedish had been modified, showed, however, no difference between the L2 groups. Instead, both L2 groups scored significantly lower than the native speaker group. The three groups did not differ in their ability to discriminate non‐modified words. These findings demonstrate that L1 loss is not a crucial condition for successfully acquiring an L2, which in turn is taken as support for a maturational constraints view on L2 acquisition. A video abstract of this article can be viewed at: https://youtu.be/1J9X50aePeU
Successful rhIGF1 treatment for over 5 years in a patient with severe insulin resistance due to homozygous insulin receptor mutation
Authors: Carmody D. , Ladsaria S. S. , Buikema R. K. , Semple R. K. , Greeley S. A. W. 
Published: August 2015

AbstractBackgroundCongenital insulin resistance syndromes are caused by biallelic mutations within the insulin receptor gene (INSR). Recombinant human insulin‐like growth factor (rhIGF1) has been used with mixed success; however, rigorous assessment of its efficacy is lacking. Here, we describe a child with a homozygous mutation in INSR successfully treated with rhIGF1 for more than 5 years.Case reportThe patient presented with osmotic diabetes symptoms and was noted to have dysplastic dentition, hypertrichosis, coarse and dysmorphic facial features. Acanthosis nigricans, skin tags and rugated hyperkeratosis were also evident on the posterior neck, axilla and groin. A homozygous INSR essential splice site mutation (c.1268 + 2T > C, p.G374 fs*12) was identified, for which both parents were found to be heterozygous. The patient was treated with twice daily injections of rhIGF1 and metformin for more than 5 years with improvement in her acanthosis nigricans, hyperkeratosis and hypertrichosis. A dramatic fall in fasting insulin, HOMA–IR and HbA1c has been maintained over the entire course of treatment without adverse effects. Her linear growth velocity has remained on target for her predicted adult height.DiscussionOur case demonstrates the effectiveness of rhIGF1 as an early treatment in a patient with a biallelic mutation within INSR without evidence of fluid retention, retinopathy, muscle pain, heart failure, cerebral infarcts or benign intracranial hypertension. Her case suggests rhIGF1 can and should be considered as an initial treatment option instead of as a final option in those with INSR mutations.
The attracting power of the gaze of politicians is modulated by the personality and ideological attitude of their voters: a functional magnetic resonance imaging study
Authors: Cazzato Valentina , Liuzza Marco Tullio , Caprara Gian Vittorio , Macaluso Emiliano , Aglioti Salvatore Maria 
Published: August 2015

AbstractObserving someone rapidly moving their eyes induces reflexive shifts of overt and covert attention in the onlooker. Previous studies have shown that this process can be modulated by the onlooker's personality, as well as by the social features of the person depicted in the cued face. Here, we investigated whether an individual's preference for social dominance orientation, in‐group perceived similarity (PS), and political affiliation of the cued‐face modulated neural activity within specific nodes of the social attention network. During functional magnetic resonance imaging, participants were requested to perform a gaze‐following task to investigate whether the directional gaze of various Italian political personages might influence the oculomotor behaviour of in‐group or out‐group voters. After scanning, we acquired measures of PS in personality traits with each political personage and preference for social dominance orientation. Behavioural data showed that higher gaze interference for in‐group than out‐group political personages was predicted by a higher preference for social hierarchy. Higher blood oxygenation level‐dependent activity in incongruent vs. congruent conditions was found in areas associated with orienting to socially salient events and monitoring response conflict, namely the left frontal eye field, right supramarginal gyrus, mid‐cingulate cortex and left anterior insula. Interestingly, higher ratings of PS with the in‐group and less preference for social hierarchy predicted increased activity in the left frontal eye field during distracting gaze movements of in‐group as compared with out‐group political personages. Our results suggest that neural activity in the social orienting circuit is modulated by higher‐order social dimensions, such as in‐group PS and individual differences in ideological attitudes.
Business Cycle Synchronization of CEECs with the Euro Area: A Regime Switching Approach
Authors: Di Giorgio Carlo 
Published: August 2015

AbstractThis article investigates the possible business cycle linkages between CEECs (Central and Eastern European countries) that were candidates to enter the EMU and the euro area for the period 1993 to 2014. We analyse business cycle (a)symmetries for these countries by using Markov switching autoregressive models and synchronization tests. By analysing the correlations between the cyclical fluctuations for these countries, we examine the existence of common features between the individual cycles. By distinguishing between different regimes, we show that the indications of business cycle synchronization are quite high in the recession regime, but lower in the normal and high growth regimes, with the exceptions of Hungary and Poland.