bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocytic and erythroid differentiation
Authors: Duncan Mark T. , Shin Seungjin , Wu Jia J. , Mays Zachary , Weng Stanley , Bagheri Neda , Miller William M. , Shea Lonnie D. 
Published: May 2014

ABSTRACTThe directed differentiation toward erythroid (E) or megakaryocytic (MK) lineages by the MK‐E progenitor (MEP) could enhance the ex vivo generation of red blood cells and platelets for therapeutic transfusions. The lineage choice at the MEP bifurcation is controlled in large part by activity within the intracellular signal transduction network, the output of which determines the activity of transcription factors (TFs) and ultimately gene expression. Although many TFs have been implicated, E or MK differentiation is a complex process requiring multiple days, and the dynamics of TF activities during commitment and terminal maturation are relatively unexplored. Herein, we applied a living cell array for the large‐scale, dynamic quantification of TF activities during MEP bifurcation. A panel of hematopoietic TFs (GATA‐1, GATA‐2, SCL/TAL1, FLI‐1, NF‐E2, PU.1, c‐Myb) was characterized during E and MK differentiation of bipotent K562 cells. Dynamic TF activity profiles associated with differentiation towards each lineage were identified, and validated with previous reports. From these activity profiles, we show that GATA‐1 is an important hub during early hemin‐ and PMA‐induced differentiation, and reveal several characteristic TF interactions for E and MK differentiation that confirm regulatory mechanisms documented in the literature. Additionally, we highlight several novel TF interactions at various stages of E and MK differentiation. Furthermore, we investigated the mechanism by which nicotinamide (NIC) promoted terminal MK maturation using an MK‐committed cell line, CHRF‐288‐11 (CHRF). Concomitant with its enhancement of ploidy, NIC strongly enhanced the activity of three TFs with known involvement in terminal MK maturation: FLI‐1, NF‐E2, and p53. Dynamic profiling of TF activity represents a novel tool to complement traditional assays focused on mRNA and protein expression levels to understand progenitor cell differentiation. Biotechnol. Bioeng. 2014;111: 2082–2094. © 2014 Wiley Periodicals, Inc.
Emission Source Characterization during an Ethylene Plant Shutdown
Authors: Wang Ziyuan , Xu Qiang , Ho Thomas C. 
Published: May 2014

AbstractTo conduct a well‐planned plant shutdown, so as to reduce flare emissions for the sake of plant profitability and local environmental sustainability, one of the primary tasks is to perform comprehensive and precise accountings for flare emissions. Since the literature is still lacking systematic and quantitative studies, plant‐wide dynamic simulations are employed to simulate an ethylene plant shutdown and characterize its flare emission sources through which dynamic emission profiles of various emission species changing with respect to time are obtained. Plant shutdown emission inventories are enriched with details for point emission sources, and possible technical supports are provided to both industry and environmental agencies on evaluating and developing cost‐effective flare minimization strategies in the future.
ChemInform Abstract: Ba1‐xRbxFe2As2 and Generic Phase Behavior of Hole‐Doped 122‐Type Superconductors.
Authors: Peschke Simon , Stuerzer Tobias , Johrendt Dirk 
Published: May 2014

AbstractThe solid solution Ba1‐xRbxFe2As2 (0 ≤ x ≤ 1) is prepared by heating stoichiometric amounts of the elements (Nb crucible, 873—1173 K, several annealing cycles) and by solid state reaction of mixtures of BaFe2As2 and RbFe2As2 (Nb enclosed alumina crucible in silica ampoules, 1023—1123 K).
ChemInform Abstract: Synthesis and Structural Characterization of the Alkali Thiophosphates Na2P2S6, Na4P2S6, K4P2S6, and Rb4P2S6.
Authors: Kuhn Alexander , Eger Roland , Nuss Juergen , Lotsch Bettina V. 
Published: May 2014

AbstractThe hitherto unknown, but expected title compounds are synthesized from stoichiometric mixtures of the elements (973—1120 K, 10 h) and characterized by single crystal XRD.
ChemInform Abstract: Synthesis and Structural Characterization of Cs2Ga2Se5.
Authors: Friedrich Daniel , Schlosser Marc , Pfitzner Arno 
Published: May 2014

AbstractCs2Ga2Se5 is obtained by thermal decomposition of CsN3 in the presence of stoichiometric amounts of GaSe and Se (evacuated quartz ampoule, 873 K, several days).
ChemInform Abstract: Three New Vanadoborates Functionalized with Zinc Complexes.
Authors: Liu Xing , Zhao Rongqing , Zhou Jian , Liu Meihua 
Published: May 2014

AbstractCompound (III) crystallizes in the monoclinic space group C2/m with Z = 4 and contains the new cluster [Zn4V10B34O84H10] 8‐.
ChemInform Abstract: Three‐Dimensional Molecular‐Based Magnet of Octacyanometalate‐Based Tungstate(V)‐Cobalt(II) Bimetallic Assembly with TC = 26 K.
Authors: Gao Zhi Kun , Gao Qing Wei , Liu Hai Sheng , Yang Bing Hui , Wang Ying , Ding Bin , Liu Ju Yan , Zhao Xiao Jun 
Published: May 2014

Abstract{[CoII4(H2O)6 (C2O4)] [WV(CN)8] 2·6H2O}n is synthesized by dropwise addition of an aqueous solution of Na3[W(CN)8] to a mixture of Co(OAc)2 and oxalic acid in MeOH followed by evaporation at room temperature (two months; 35% yield).
ChemInform Abstract: Synthesis and Characterization of [Ru@Ge12]3—: An Endohedral 3‐Connected Cluster.
Authors: Espinoza‐Quintero Gabriela , Duckworth Jack C. A. , Myers William K. , McGrady John E. , Goicoechea Jose M. 
Published: May 2014

AbstractCompound (III) crystallizes in the monoclinic space group P21 with Z = 2.
ChemInform Abstract: Triphenylphosphinecarboxamide: An Effective Reagent for the Reduction of Azides and Its Application to Nucleic Acid Detection.
Authors: Saneyoshi Hisao , Ochikubo Tatsuya , Mashimo Takushi , Hatano Ken , Ito Yoshihiro , Abe Hiroshi 
Published: May 2014

AbstractIn contrast to conventional methods in this procedure no subsequent hydrolysis step is necessary.
ChemInform Abstract: Copper‐Mediated Regioselective Homocoupling of Thiophenes and Indoles via Directed C—H Cleavage.
Authors: Miura Masahiro , Hirano Koji , Odani Riko , Nishino Mayuko , Satoh Tetsuya 
Published: May 2014

AbstractThe regioselectivity of the homocoupling reaction of thiophenes and indoles is studied.
ChemInform Abstract: Efficient Synthesis of α‐Quaternary α‐Hydroxy‐β‐amino Esters via Silyl Glyoxylate‐Mediated Three‐Component Reactions.
Authors: Jiang Jiu‐Long , Yao Ming , Lu Chong‐Dao 
Published: May 2014

AbstractThe reaction products are isolated with <90% diastereoisomeric excess.
ChemInform Abstract: Stereodivergent Synthesis of Enantioenriched 4‐Hydroxy‐2‐cyclopentenones.
Authors: Singh Gurpreet , Meyer Angelica , Aube Jeffrey 
Published: May 2014

AbstractUsing a known pathway, chiral diol (II) can be easily obtained via Noyori reduction which establishes the product stereochemistry in a single step.
ChemInform Abstract: Synthesis of Novel Benzofuran Fused 1‐Azaazulene Derivative by Tandem Intermolecular Suzuki Coupling/Intramolecular Buchwald‐Hartwig Type Coupling.
Authors: Fujii Hiroyuki , Abe Noritaka , Sanada Kazuya , Kawai Yu , Ikeda Reiko , Konakahara Takeo 
Published: May 2014

AbstractAzaazulene (III) is synthesized either by O‐arylation/C—C coupling of compounds (I) and (II) or by title tandem reaction sequence.
ChemInform Abstract: Synthesis of Polycyclic Indole Skeletons by a Gold(I)‐Catalyzed Cascade Reaction.
Authors: Wang Tao , Shi Shuai , Pflaesterer Daniel , Rettenmeier Eva , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K. 
Published: May 2014

AbstractThe title synthesis starts from simple, easily available urea‐substituted 3‐phenylpropargyl alcohols.
ChemInform Abstract: Bi(OTf)3 as a Dual Role Catalyst. Synthesis of Substituted Morpholine Derivatives via Catalytic O‐Allylation.
Authors: Cook Gregory R. , Hayashi Ryuji , Park Jin‐A 
Published: May 2014

Abstractcis‐1,4‐Disubstituted morpholines are stereoselectively obtained by Bi(O‐Tf)3‐catalyzed ring closing O‐allylation under mild reaction conditions without the need of any base.
ChemInform Abstract: Selective Reduction of Amino Allenephosphonates: Preparation of α‐Amino Vinylphosphonates.
Authors: Adler Pauline , Gomes Filipe , Fadel Antoine , Rabasso Nicolas 
Published: May 2014

AbstractA new protocol for the synthesis of a variety of the title compounds is presented with good to excellent stereoselectivity towards the (Z)‐conformation.
ChemInform Abstract: Synthesis of Isoxazolin‐5‐one Glucosides by a Cascade Reaction.
Authors: Becker Tobias , Goerls Helmar , Pauls Gerhard , Wedekind Roland , Kai Marco , von Reuss Stephan H. , Boland Wilhelm 
Published: May 2014

AbstractA new and efficient approach to the natural sugar derivative (VI) and its α‐isomer (V) is reported.
ChemInform Abstract: Heavier Group 2 Grignard Reagents of the Type Aryl‐ae(L)n‐X (Post‐Grignard Reagents)
Authors: Westerhausen Matthias , Langer Jens , Krieck Sven , Fischer Reinald , Goerls Helmar , Koehler Mathias 
Published: May 2014

AbstractReview: 181 refs.
Production of 5‐Hydroxymethylfurfural from Fructose in Ionic Liquid Efficiently Catalyzed by Cr(III)‐Al2O3 Catalyst
Authors: Song Changhua , Liu Hui , Li Yuan , Ge Shuai , Wang Hongwei , Zhu Wenshuai , Chang Yonghui , Han Changri , Li Huaming 
Published: May 2014

AbstractA series of metal‐Al2O3 catalysts were prepared simply by the conventional impregnation with Al2O3 and metal chlorides, which were applied to the dehydration of fructose to 5‐hydroxymethylfurfural (HMF). An agreeable HMF yield of 93.1% was achieved from fructose at mild conditions (100°C and 40 min) when employing Cr(III)‐Al2O3 as catalyst in 1‐butyl‐3‐methylimidazolium chloride ([Bmim]Cl). The Cr(III)‐Al2O3 catalyst was characterized via XRD, DRS and Raman spectra and the results clarified the interaction between the Cr(III) and the alumina support. Meanwhile, the reaction solvents ([Bmim]Cl) collected after 1st reaction run and 5th reaction run were analyzed by ICP‐OES and LC‐ITMS and the results confirmed that no Cr(III) ion was dropped off from the alumina support during the fructose dehydration. Notably, Cr(III)‐Al2O3 catalyst had an excellent catalytic performance for glucose and sucrose and the HMF yields were reached to 73.7% and 84.1% at 120°C for 60 min, respectively. Furthermore, the system of Cr(III)‐Al2O3 and [Bmim]Cl exhibited a constant stability and activity at 100°C for 40 min and a favorable HMF yield was maintained after ten recycles.
Synthesis and Antitumor Activity Evaluation of Pyrimidine Analogues Bearing Urea Moiety
Authors: Shao Kunpeng , Zhang Xuyao , Zhang Xiaosong , Xue Dengqi , Ma Liying , Zhang Qiurong , Liu Hongmin 
Published: May 2014

AbstractA series of 4‐anilino‐6‐phenylpyrimidines containing urea moiety were synthesized and the structures of all products were confirmed by 1H NMR, 13C NMR and HRMS. The antiproliferative activities of these compounds were evaluated against three human tumor cell lines (MGC‐803, MCF‐7 and EC‐109) by applying the MTT assay method. compounds 4a, 4b and 6a showed the most effective activity, among which, 6a was more cytotoxic than 5‐fluorouracil against all tested human cancer cell lines with IC50 values ranging from 1.80 to 2.72 µmol·L−1.
A Study of Electron Beam Induced Deposition and Nano Device Fabrication Using Liquid Cell TEM Technology
Authors: Chen Xin , Zhou Lihui , Wang Ping , Cao Hongliang , Miao Xiaoli , Wei Feifei 
Published: May 2014

AbstractSiCx nano dots and nano wires with sizes from 60 nm to approximately 2 µm were fabricated using liquid cell transmission electron microscope (TEM) technology. A SiCl4 in CH2Cl2 solution was sealed between two pieces of Si3N4 window grids in an in situ TEM liquid cell. Focused 200 keV electron beams were used to bombard the sealed precursors, which caused decomposition of the precursor materials, and deposition of the nano materials on the Si3N4 window substrates. The size of nano dots increased with beam exposure time, following an approximately exponential relationship with the beam doses. Secondary electrons are attributed as the primary sources for the Si and C reduction. A nano device was formed from a deposited nano wire, with its electrical property characterized.
Organocatalytic Stereoselective Synthesis of 3‐Alkyl‐3‐hydroxy‐2‐oxindoles Catalyzed by Novel Water‐compatible Axially Unfixed Biaryl‐based Bifunctional Organocatalysts
Authors: Zhao Hongwu , Meng Wei , Yang Zhao , Tian Ting , Sheng Zhihui , Li Hailong , Song Xiuqing , Zhang Yutong , Yang Sen , Li Bo 
Published: May 2014

AbstractIn this work, six novel axially unfixed biaryl‐based water‐compatible bifunctional organocatalysts were designed and synthesized for the organocatalytic access to a variety of 3‐alkyl‐3‐hydroxy‐2‐oxindole derivatives via aldol reactions in water. Organocatalyzed by 5a, the direct aldol reactions of isatins with enolisable ketones underwent readily in water, furnishing the structurally diverse 3‐alkyl‐3‐hydroxy‐2‐oxindoles in various stereoselectivities (up to>99% dr and >99% ee). Moreover, a plausible transition state of the conducted aldol reactions was hypothesized to shed light on the observed stereoselectivities of the obtained 3‐alkyl‐3‐hydroxy‐2‐oxindoles.
Catalytic CN Bond Alkynylation of N‐Benzylic Sulfonamides with Terminal Alkynes
Authors: Liu Congrong , Yang Fulai , Wang Tingting 
Published: May 2014

AbstractA new cross‐coupling reaction of N‐benzylic sulfonamides with terminal alkynes for the synthesis of internal alkynes is reported. In the presence of 5 mol% of (Tf)2NH/Bi(OTf)3 (1:1), a broad range of N‐benzylic sulfonamides react smoothly with arylacetylenes to afford structurally diverse internal alkynes in moderate to excellent yields. We reasoned that vinyl cations could be formed by the regioselective attack of terminal alkynes with benzyl cations generated in situ from N‐benzylic sulfonamides under acidic conditions, which then eliminated to form a carbon‐carbon triple bond.
Synthesis of Ferrocene‐Modified Carbon Nitride Photocatalysts by Surface Amidation Reaction for Phenol Synthesis
Authors: Ye Xiangju , Zheng Yun , Wang Xinchen 
Published: May 2014

AbstractA polymeric Fc‐CO‐NH‐C3N4 (Fc‐CN) material was synthesized by amidation reaction of ferrocenecarboxylic acid (Fc‐COOH) with NH2 groups on the surface of mesoporous graphitic carbon nitride (MCN). The properties of the as‐synthesized samples were characterized by X‐ray diffraction, Fourier transform infrared spectroscopy, UV‐Vis diffuse reflectance spectra, N2 adsorption‐desorption isotherm, photoluminescence spectroscopy, transmission electron microscopy, electron paramagnetic resonance, (photo)electrochemical measurement and X‐ray photoelectron spectroscopy. The resultant catalysts were investigated as heterogeneous catalysts for the selective oxidation of benzene to phenol using H2O2 as a green oxidant under visible light irradiation. The results reveal that Fc‐modified samples can not only extend the visible light absorption, but also accelerate the bulk‐to‐surface charge transfer and separation via surface dyadic structures, both of which are favorable for phenol production from benzene photocatalytic hydroxylation with H2O2. Under the optimal conditions, up to 16.9 % phenol yield (based on benzene) is obtained by Fc‐CN/1.5‐5 sample, and the corresponding Fe content is about 0.64 wt%. Furthermore, after the second run, no significant decrease of the activity (in term of TOF) and the selectivity is found in Fc‐CN/1.0‐5 sample. Combined with the experimental results and Fenton‐chemistry, a possible photocatalytic reaction mechanism on the hydroxylation of benzene to phenol at neutral medium with visible light is proposed.
A computational framework for simulation of the delivery of substances into cells
Authors: Campello Eduardo M. B. , Zohdi Tarek I. 
Published: May 2014

SUMMARYIn this paper, we propose a simple computational framework for the rapid simulation of the delivery of substances into cells. Our approach treats the substances and the cell membrane as a collection of particles forming a discrete dynamical system, which is described by Newtonian equations in a purely mechanistic way. Detailed aspects about the modeling of particle interactions are discussed and resolved. The main advantage of such an approach is that it can offer a good qualitative picture of the delivery mechanism without the need to resort to detailed descriptions of the complex intermolecular interactions that are observed at small scales of the cell membrane. A numerical time integration scheme is formulated for solution of the system dynamics, and examples of simulations are provided. Computational particle‐based models render reliable and fast simulation tools. We believe they can be very useful to help advance the design of delivery systems. Copyright © 2014 John Wiley & Sons, Ltd.
Association of eating disorder symptoms with internalizing and externalizing dimensions of psychopathology among men and women
Authors: Mitchell Karen S. , Wolf Erika J. , Reardon Annemarie F. , Miller Mark W. 
Published: May 2014

ABSTRACTObjectiveA large body of factor analytic research supports the idea that common mental disorders are organized along correlated latent dimensions termed internalizing and externalizing. Eating disorders (EDs) have been associated with both internalizing (mood and anxiety disorders) and externalizing (substance use, antisocial personality disorder) forms of psychopathology. Previous studies found that EDs are most strongly related to internalizing disorders. However, no previous factor analytic studies of EDs and the internalizing/externalizing dimensions have evaluated if EDs align with these spectra similarly for men and women. We examined the location of anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED) symptoms within this model of psychopathology among a sample of veterans, a population traditionally understudied in EDs.MethodData were from two studies of veterans and their intimate partners (N = 453 men and 307 women). Participants were administered the Structured Clinical Interview for DSM‐IV without skip‐outs. Lifetime symptom severity scores were used in confirmatory factor analytic models.ResultsA model with AN, BN, and BED symptoms loading onto the distress subfactor of the internalizing domain fit the data best in the full sample and the male and female subsamples. This model was statistically equivalent for men and women.DiscussionAll three EDs loaded onto distress, indicating that these conditions overlap with psychopathology characterized by negative affect. Investigating latent dimensions of psychopathology is one approach to identifying common factors that partially account for patterns of comorbidity among psychiatric disorders, which may aid in translating research findings into clinical practice. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:860–869)
2‐Amino‐4‐(2‐pyridyl)thiazole as Chelating Ligand: A Dinuclear Oxido‐Bridged Ferric Complex and Mononuclear 3d Metal Complexes
Authors: Huxel Timo , Leone Selina , Lan Yanhua , Demeshko Serhiy , Klingele Julia 
Published: May 2014

Abstract2‐Amino‐4‐(2‐pyridyl)thiazole (H2L) complexes of iron(III), iron(II), cobalt(II), nickel(II) and copper(II) have been prepared for the first time. The oxido‐bridged dinuclear ferric complex [(H2L)2FFeIII(μ‐O)FeIIIF(H2L)2](BF4)2 (1) and the mononuclear difluorido complex [FeIII(H2L)2F2](BF4) (2) were prepared with Fe(BF4)2·6H2O. Complex 1 contains strong antiferromagnetically coupled iron(III) ions. In addition, the mononuclear 3:1‐type complex [Co(H2L)3](ClO4)2 (3) and the mononuclear 2:1‐type complexes [Cu(H2L)2](ClO4)2 (4) and [M(H2L)2(NCX)2] (5: M = Fe, X = S; 6: M = Fe, X = Se; 7: M = Co, X = S; 8: M = Ni, X = S) were prepared.
Synthesis of Tetrasubstituted Furan Derivatives by Condensation of 1,3‐Diketones with Cyclic α‐Hydroxy‐β‐oxo Esters
Authors: Schickmous Barhiem , Christoffers Jens 
Published: May 2014

AbstractTetrasubstituted 3‐acylfuran derivatives were obtained by condensation of acetylacetone with alicyclic and heterocyclic α‐hydroxy‐β‐oxo esters under acidic conditions [0.1 equiv. cerium(III) salt in AcOH]. With [b]‐annulated 4‐acyl‐3‐hydroxy‐5‐methylfuran‐2‐carboxylates as common intermediates, the reaction proceeded along different pathways depending on the starting materials used: Alicyclic α‐hydroxy‐β‐oxo esters gave cycloalkane‐annulated furans as products. The ester group was lost after saponification and decarboxylation at elevated temperature. A thiopyrano[3,4‐b]‐annulated 2H‐furan was obtained when starting from a tetrahydrothiopyranone derivative. With piperidones or a tetrahydropyranone as starting materials, the heterocyclic six‐membered ring was cleaved in a retro‐Mannich type reaction and one carbon atom was lost. 4‐Acetyl‐5‐methylfuran‐2‐carboxylates with a 2‐amino or 2‐hydroxyethyl substituent in the 3‐position are obtained in these cases.
Validating speed of onset as a key component of good analgesic response in acute pain
Authors: Moore R.A. , Derry S. , Straube S. , Ireson‐Paine J. , Wiffen P.J. 
Published: May 2014

AbstractBackgroundPrevious analysis of a single data set in acute pain following third molar extraction demonstrated a strong relationship between the speed of reduction of pain intensity and overall pain relief, as well as need for additional analgesia.MethodsIndividual patient data analysis of a single randomized, double‐blind trial of placebo, paracetamol 1000 mg, ibuprofen sodium 400 mg and ibuprofen‐poloxamer 400 mg following third molar extraction. Visual analogue scale pain intensity (VASPI) and other measurements were made at baseline, every 5–45 min, and at 60, 90, 120, 180, 240, 300 and 360 min.ResultsMost patients produced consistent VASPI results over time. For placebo and paracetamol, few patients achieved low VASPI scores and maintained them. For both ibuprofen formulations, VASPI scores fell rapidly during the first hour and were then typically maintained until later re‐medication. Analysis of all patients showed that rapid VASPI reduction in the first hour was strongly correlated with good overall pain relief (high total pain relief over 0–6 h), and with lesser need for additional analgesia within 6 h. Results for this analysis were in very good agreement with a previous analysis, validating the relationship between fast initial pain intensity reduction and overall good pain relief in this setting.ConclusionsIn acute pain following third molar extraction, faster acting analgesic formulations provide earlier onset of pain relief, better overall pain relief and a less frequent need for additional analgesia, indicating longer lasting pain relief.
Synthesis of New Types of Ferrocene Dimers Bridged by a Fused Oligothiophene Spacer and Study of Their Electrochemical Oxidation Process via a Mixed‐Valence State
Authors: Muraoka Hiroki , Watanabe Yudai , Takahashi Aki , Kamoto Hironobu , Ogawa Satoshi 
Published: May 2014

ABSTRACTWe describe the synthesis and electrochemical oxidation properties of ferrocene dimers bridged by a fused oligothiophene spacer (thienothiophene, benzodithiophene, and dithienothiophene), which are designed as new types of ferrocene dimers for the study of the oxidation process via a mixed‐valence state. The electrochemical properties of all ferrocene dimers were examined by a cyclic voltammetry technique. The voltammograms showed a reversible two‐electron oxidation wave derived from the two ferrocene fragments with a potential difference between the first and second oxidation waves (ΔE1/2 = E1/2(+1/+2) – E1/2(0/+1)), which ranges from 0 to +127 mV. This result indicates that the chemical structure of the fused oligothiophene spacer can be attuned to the two‐electron oxidation process of two ferrocene terminals via a mixed‐valence state.