bluuebunny/crossref_metadata_2025_split huggingface dataset:
STAT3 expression correlates with prognosis of thymic epithelial tumors
Authors: Li Chao , Wang Zhou , Liu Yan , Wang Peng , Zhang Runqi 
Published: April 2013

Abstract

Background
More and more evidences demonstrate the significance of Signal transducers and activators of transcription 3(STAT3) in oncogenesis and tumor development. However, little systematic researches have been reported on the correlation between STAT3 and thymic epithelial tumor (TET).

Methods
Expression of STAT3 protein in 80 thymic epithelial tumors was detected by immunohistochemistry (IHC). The difference of STAT3 expression was compared by the χ
2 test. Estimation of survival was calculated using the Kaplan-Meier method, and the statistical differences were analyzed using the Log-rank test.

Results
Positive expression of STAT3 protein was significantly associated with Masaoka staging and WHO histological classification (P < 0.05), but not with age, gender, or tumor size. The rate of postoperative recurrence/metastasis was 33.33% in STAT3-positive tumors, compared with 4.55% in negative ones (P < 0.05). 5-year survival was significantly lower in STAT3-positive subjects (61.11%) than in negative ones (97.73%) (P < 0.01); In patients in Masaoka stage III or IV and WHO B3 or C, 5-year survival rate of subjects positive in STAT3 (35.00%, 35.00%) was statistically lower than that of the negative ones (92.31%, 91.67%). Cox regression analysis revealed that positive expression of STAT3 protein was an independent prognostic factor of thymic epithelial tumors (HR = 9.325, P = 0.044).

Conclusion
Positive expression of STAT3 protein increases along with the rising malignant degree of thymic epithelial tumors. It may be considered as an independent prognostic parameter with good prognostic value to evaluate the possibility of recurrence/metastasis in patients with thymic epithelial tumor.
Occurrence of Temnocephala (Platyhelminthes: Temnocephalida) in Immatures of Kempnyia reticulata (Enderlein) (Insecta: Plecoptera: Perlidae)
Authors: Avelino-Capistrano Fernanda , Barbosa Leandro Silva , Cunha André Mallemont 
Published: April 2013

First register of Temnocephala (Platyhelminthes: Temnocephalida) in immature of Kempnyia reticulata (Enderlein) (Plecoptera: Perlidae). The insects were collected in rivers of Estação Biológica de Santa Lúcia, Santa Teresa, Espirito Santo, Brazil.
Primeiro registro de Temnocephala (Platyhelminthes: Temnocephalida) em imaturos de Kempnyia reticulata (Enderlein) (Plecoptera: Perlidae).
Resumo. Primeiro registro de Temnocephala (Platyhelminthes: Temnocephalida) em imaturos de Kempnyia reticulata (Enderlein) (Plecoptera: Perlidae). Os insetos foram coletados em um riacho da Estação Biológica de Santa Lúcia, Santa Teresa, Espírito Santo, Brasil.
Histomorphological Characteristics of Digestive and Reproductive Organs of Lutzomyia wellcomei Fraiha, Shaw & Lainson (Diptera, Psychodidae)
Authors: Pegado Silva Vanessa Escóssia , Da Silva Naissandra Bezerra , Pinheiro Marcos Paulo Gomes , Freitas Maria de Lourdes , Freire de Melo Ximenes Maria de Fátima 
Published: April 2013

Sandflies are important vectors of tegumentary and visceral leishmaniasis in different countries. This study aimed at analyzing the histomorphological characteristics of digestive and reproductive organs in Lutzomyia wellcomei (Fraiha, Shaw & Lainson) using light microscopy techniques. Thirty females from the rural area of Nísia Floresta, Rio Grande do Norte state were selected, microsectioned and analyzed with an optical microscope using conventional hematoxylin-eosin staining. Results show three well-characterized regions in the digestive tube: the stomodeum, mesentery and proctodeum. The stomodeum is lined internally with a basal and epithelial membrane; the mesentery has a peritrophic matrix formed above the stomodeum lining consisting of the simple cubic epithelium overlapping the conjunctive, also common to a capsule of gonadal lining; and the proctodeum, which structurally resembles the mesentery, but with a pyloric sphincter limiting the posterior midgut. Enveloping the digestive tube is the peritoneal membrane, of mesodermal origin. Richly-detailed internal morphological characteristics of L. wellcomei have widened knowledge of this Leishmania braziliensis (Vianna)-transmitting species, an etiologic agent of American tegumentary leishmaniasis.
Características Histomorfológicas de Órgãos da Digestão de Lutzomyia wellcomei Fraiha, Shaw & Lainson (Diptera, Psychodidae)
Resumo. Os flebotomíneos se destacam como importantes transmissores das leishmanioses tegumentar e visceral em diferentes países. O objetivo desse estudo foi analisar características histomorfológicas de órgãos da digestão de Lutzomyia wellcomei (Fraiha, Shaw & Lainson) por meio de técnicas de microscopia. Trinta fêmeas provenientes de área rural do município de Nísia Floresta, Rio Grande do Norte foram selecionadas, microseccionadas e analisadas por microscopia ótica. Métodos de coloração histológica por hematoxilina-eosina foram empregados nas análises. Os resultados mostram o trato digestório com as três regiões bem caracterizadas, estomodeo, mesêntero e proctodeo. O estomodeo possui uma membrana basal e uma membrana epitelial que o reveste internamente; o mesêntero possui matriz peritrófica formada acima do revestimento do estomodeo constituído de epitélio cúbico simples sobreposto ao conjuntivo comum também a uma cápsula de revestimento gonadal; e o proctodeo que se assemelha estruturalmente com o mesêntero, possuindo ainda, uma região pilórica limitando o intestino médio do posterior. Envolvendo o tubo digestório, está a membrana peritonial, de origem mesodérmica. As características morfológicas internas, observadas com riqueza de detalhes em L. wellcomei ampliam o conhecimento acerca dessa espécie, transmissora de Leishmania braziliensis (Vianna), agente etiológico de leishmaniose tegumentar americana.
Incidência de Varroa destructor (Anderson e Trueman) em criação de abelhas com ferrão na região de Sinop, MT
Authors: Torres Rodrigo de Nazaré Santos , Barreto Marliton Rocha 
Published: April 2013

Quanto às enfermidades apícolas descreve-se que o Brasil está em situação vantajosa comparando com outros países, por apresentar enxames rústicos que, por serem mais resistentes a doenças, dispensam a utilização de antibióticos. Entretanto, a dinâmica de populações do ácaro Varroa mostrou ser muito diferente das outras regiões afetadas pela varroose sendo os primeiros índices registrados superiores a 20% e, ainda, se têm poucos trabalhos em relação à taxa de infestação em diferentes regiões do Brasil. Desta forma, este trabalho teve como objetivo realizar um levantamento de incidência do ácaro Varroa destructor (Anderson & Trueman) em colmeias na região de Sinop, MT. As coletas foram realizadas nos meses de julho e agosto de 2011 em oito apiários fixos. Abelhas que estavam próximas aos quadros centrais foram coletadas e no laboratório de Entomologia da UFMT, Campus Universitário de Sinop, foi realizada a triagem e armazenamento das abelhas e ácaros. Os apiários visitados estão situados nos municípios de Santa Carmen e de Sinop e estão localizados em áreas de preservação, embora estejam próximos a áreas destinadas ao cultivo de soja e milho. Como resultado, obteve-se média de infestação superior a 9%.
The incidence of Varroa destructor (Anderson & Trueman) in the Breeding of Stinging Bees in Sinop and Surrounding Regions, Mato Grosso, Brazil

Abstract. In terms of apiculture diseases, Brazil stands in an advantageous situation compared to other countries, because of its rustic swarms that are more resistant to diseases, and, therefore, do not require antibiotics. Nevertheless, it was observed that the Varroa mite population was very different from those of other regions affected by varroatosis, with the first recorded rates above 20%. Furthermore, the studies regarding infestation rates in Brazil are scarce, which poses a barrier for comparisons in this regard. Hence, this study was performed with the objective to survey the incidence of the Varroa destructor (Anderson & Trueman) mite in bee colonies located in the region of Sinop, Mato Grosso. Samples were collected during July and August 2011 in eight apiaries fixed. Bees that were close to the central frames were collected and laboratory UFMT of Entomology, University Campus of Sinop was performed sorting and storage of bees and mites. Visited apiaries are located in the cities of Santa Carmen and Sinop and are located in areas of preservation, although they are near areas for the cultivation of soybeans and corn. The study found that the mean infestation was above 9%.
A List of Current Valid Blow Fly Names (Diptera: Calliphoridae) in the Americas South of Mexico with Key to the Brazilian Species
Authors: Kosmann Cecília , Mello Rubens Pinto de , Harterreiten-Souza Érica Sevilha , Pujol-Luz José Roberto 
Published: April 2013

The calliphorids flies comprise a heterogenous family found in all zoogeographical regions, with over 1,000 species and 150 genera described. The blow flies have a great medical and veterinary importance, and can be use in forensic science, especially in order to estimate the postmortem interval. Despite its wide distribution and importance, the group presents many taxonomic problems, and many conflicting records regarding the number of species in the Neotropical Region. In this paper, we list all species of Calliphoridae found in the Americas south of Mexico, based on reports in the literature between the years 1960 and 2012. There are 29 genera and 99 species recognized distributed in seven subfamilies: Calliphorinae (three genera and eight species), Chrysomyinae (seven genera and 28 species), Luciliinae (one genus and 17 species), Mesembrinellinae (nine genera and 33 species), Polleniinae (one genus and one species), Rhiniinae (one genus and one species), and Toxotarsinae (seven genera and 11 species). An identification key for the species that occur in Brazil is presented.
Lista Atualizada de Nomes Válidos de Moscas-Varejeiras (Diptera: Calliphoridae) das Américas ao Sul do México, com uma Chave para as Espécies que Ocorrem no Brasil

Resumo. Os califorídeos constituem uma família heterogênea encontrada em todas as regiões zoogeográficas, com mais de 1.000 espécies e 150 gêneros. As moscas-varejeiras possuem grande importância médica e veterinária, e podem ainda ser utilizadas nas ciências forenses, principalmente para estimar o intervalo pós-morte. Apesar da sua vasta distribuição e importância, o grupo apresenta muitos problemas taxonômicos e diversos registros conflitantes no tocante ao número de espécies presentes na região Neotropical. Neste artigo nós listamos todas as espécies de Calliphoridae encontradas nas Américas ao sul do México, baseadas em registros na literatura entre os anos de 1960 e 2012. Existem 29 gêneros e 99 espécies reconhecidas e distribuídas em sete subfamílias: Calliphorinae (três gêneros e oito espécies), Chrysomyinae (sete gêneros e 28 espécies), Luciliinae (um gênero e 17 espécies), Mesembrinellinae (nove gêneros e 33 espécies), Polleniinae (um gênero e uma espécie), Rhiniinae (um gênero e uma espécie) e Toxotarsinae (sete gêneros e 11 espécies). Uma chave de identificação para as espécies que ocorrem no Brasil é apresentada.
Call for Papers—Special Issue of Operations Research: Information and Decisions in Social and Economic Networks
Authors: Anderson Eddie , Gamarnik David , Kleywegt Anton , Ozdaglar Asuman 
Published: April 2013

Networks have become increasingly pervasive in our lives: social networks not only have a defining impact on consumer choice but are also central in social and political decisions, ranging from political discourse in the blogosphere to the organization and coordination of protests in the Arab Spring. Economic and financial transactions also increasingly occur over large, complex, dynamically changing networks, not only contributing to the efficient allocation of resources, but also occasionally creating large, systemic, and poorly understood risks. Similarly, network effects are now seen as major elements in healthcare, smart power grids, urban transportation, and more. We invite high-quality submissions in social and economic networks, construed broadly to include any system in which human action and control play a major role. We welcome contributions based on rigorous mathematical models, as well as empirical and simulation studies, that contribute to the understanding of network formation, cascades, reliability, information and action propagation, decision making, inference, measurement, and efficient optimization algorithms over networks. We seek papers that apply tools from operations research, statistics, computer science, applied mathematics, and physics to offer novel insights, build new models, and possibly provide recommendations to policy makers. To submit your paper, go to the Operations Research ScholarOne Manuscripts site at http://mc.manuscriptcentral.com/opre and follow the instructions provided. July/August 2015: Expected issue publication date.
Resequencing and Comparative Genomics of Stagonospora nodorum: Sectional Gene Absence and Effector Discovery
Authors: Syme Robert Andrew , Hane James K , Friesen Timothy L , Oliver Richard P 
Published: April 2013

Abstract
Stagonospora nodorum is an important wheat (Triticum aestivum) pathogen in many parts of the world, causing major yield losses. It was the first species in the large fungal Dothideomycete class to be genome sequenced. The reference genome sequence (SN15) has been instrumental in the discovery of genes encoding necrotrophic effectors that induce disease symptoms in specific host genotypes. Here we present the genome sequence of two further S. nodorum strains (Sn4 and Sn79) that differ in their effector repertoire from the reference. Sn79 is avirulent on wheat and produces no apparent effectors when infiltrated onto many cultivars and mapping population parents. Sn4 is pathogenic on wheat and has virulences not found in SN15. The new strains, sequenced with short-read Illumina chemistry, are compared with SN15 by a combination of mapping and de novo assembly approaches. Each of the genomes contains a large number of strain-specific genes, many of which have no meaningful similarity to any known gene. Large contiguous sections of the reference genome are absent in the two newly sequenced strains. We refer to these differences as “sectional gene absences.” The presence of genes in pathogenic strains and absence in Sn79 is added to computationally predicted properties of known proteins to produce a list of likely effector candidates. Transposon insertion was observed in the mitochondrial genomes of virulent strains where the avirulent strain retained the likely ancestral sequence. The study suggests that short-read enabled comparative genomics is an effective way to both identify new S. nodorum effector candidates and to illuminate evolutionary processes in this species.
Insight into Actin Organization and Function in Cytokinesis from Analysis of Fission Yeast Mutants
Authors: Subramanian Dhivya , Huang Junqi , Sevugan Mayalagu , Robinson Robert C , Balasubramanian Mohan K , Tang Xie 
Published: April 2013

Abstract
Actin is a key cytoskeletal protein with multiple roles in cellular processes such as polarized growth, cytokinesis, endocytosis, and cell migration. Actin is present in all eukaryotes as highly dynamic filamentous structures, such as linear cables and branched filaments. Detailed investigation of the molecular role of actin in various processes has been hampered due to the multifunctionality of the protein and the lack of alleles defective in specific processes. The actin cytoskeleton of the fission yeast, Schizosaccharomyces pombe, has been extensively characterized and contains structures analogous to those in other cell types. In this study, primarily with the view to uncover actin function in cytokinesis, we generated a large bank of fission yeast actin mutants that affect the organization of distinct actin structures and/or discrete physiological functions of actin. Our screen identified 17 mutants with specific defects in cytokinesis. Some of these cytokinesis mutants helped in dissecting the function of specific actin structures during ring assembly. Further genetic analysis of some of these actin mutants revealed multiple genetic interactions with mutants previously known to affect the actomyosin ring assembly. We also characterize a mutant allele of actin that is suppressed upon overexpression of Cdc8p-tropomyosin, underscoring the utility of this mutant bank. Another 22 mutant alleles, defective in polarized growth and/or other functions of actin obtained from this screen, are also described in this article. This mutant bank should be a valuable resource to study the physiological and biochemical functions of actin.
The Effects of Music Therapy on Vital Signs, Feeding, and Sleep in Premature Infants
Authors: Loewy Joanne , Stewart Kristen , Dassler Ann-Marie , Telsey Aimee , Homel Peter 
Published: April 2013

OBJECTIVES:Recorded music risks overstimulation in NICUs. The live elements of music such as rhythm, breath, and parent-preferred lullabies may affect physiologic function (eg, heart and respiratory rates, O2 saturation levels, and activity levels) and developmental function (eg, sleep, feeding behavior, and weight gain) in premature infants.METHODS:A randomized clinical multisite trial of 272 premature infants aged ≥32 weeks with respiratory distress syndrome, clinical sepsis, and/or SGA (small for gestational age) served as their own controls in 11 NICUs. Infants received 3 interventions per week within a 2-week period, when data of physiologic and developmental domains were collected before, during, and after the interventions or no interventions and daily during a 2-week period.RESULTS:Three live music interventions showed changes in heart rate interactive with time. Lower heart rates occurred during the lullaby (P &lt; .001) and rhythm intervention (P = .04). Sucking behavior showed differences with rhythm sound interventions (P = .03). Entrained breath sounds rendered lower heart rates after the intervention (P = .04) and differences in sleep patterns (P &lt; .001). Caloric intake (P = .01) and sucking behavior (P = .02) were higher with parent-preferred lullabies. Music decreased parental stress perception (P &lt; .001).CONCLUSIONS:The informed, intentional therapeutic use of live sound and parent-preferred lullabies applied by a certified music therapist can influence cardiac and respiratory function. Entrained with a premature infant’s observed vital signs, sound and lullaby may improve feeding behaviors and sucking patterns and may increase prolonged periods of quiet–alert states. Parent-preferred lullabies, sung live, can enhance bonding, thus decreasing the stress parents associate with premature infant care.
Silicon Platform for Mid-infrared Optofluidic Sensors
Authors: Lin Pao , Greg Lin Hao-Yu , Singh Vivek , Patel Neil Sunil , Kimerling Lionel , Agarwal Anuradha Murthy 
Published: April 2013

ABSTRACTMid-Infrared optofluidics based silicon sensor platforms are demonstrated. Silicon is a great candidate for mid-infrared optofluidics for the following reasons: (1) Silicon has a broad transmission window up to 7 um (2) Silicon offers CMOS compatible and monolithic fabrication (3) Silicon has high chemical resistance that can withstand high temperature, acid/base solution and organic solvents. (4) Silicon is a non-toxic environmentally friendly material. The fabricated mid-infrared optofluidic sensor can replace bulky instruments, such as FTIR, with a lab-on-a-chip system, while achieving much higher sensitivity.
Neutron Imaging Investigations of the Hydrogen Related Degradation of the Mechanical Properties of Zircaloy-4 Cladding Tubes
Authors: Grosse M. , Valance S. , Stuckert J. , Steinbrueck M. , Walter M. , Kaestner A. , Hartmann S. , Santisteban J. 
Published: April 2013

ABSTRACTThe hydrogen uptake and redistribution in Zircaloy-4 specimens applied to loss of coolant accident (LOCA) simulation experiments and in mechanical pre-loaded samples were investigated by means of ex-situ and in-situ neutron imaging. The results of these investigations were compared with results from mechanical tests. Hydrogen absorption may have a strong influence on the mechanical properties of zirconium alloys. A local enrichment of the absorbed hydrogen may result in brittle fracture at these positions in the tensile test. On the other hand, stress fields in the material affect the hydrogen uptake as well as its distribution in the material. In-situ investigations confirmed the existence of an initial oxide layer formed at room temperature by contact with air. This oxide layer suppresses the hydrogen uptake until dissolution in the zirconium matrix.
Density and Structure of Liquid Si-M (M=Fe, Ni, and Ge) Alloys
Authors: Mizuno Akitoshi , Murai Kentaro , Kawauchi Hiroya , Tannno Mitsuhiro , Kohara Shinji , Watanabe Masahito 
Published: April 2013

ABSTRACTIn order to elucidate a link between density and structure of liquid Si-M (M=Fe, Ni, and Ge) alloys, synchrotron x-ray diffraction experiments have been conducted with the use of a conical nozzle levitation technique. Liquid structure factors of the Si-Fe and the Si-Ni alloys indicate a correlation of medium range ordering with the increase of the Si content. Although the total molar volume expands with the increase of the Si content in these alloys, the concentration dependence of the average interatomic distance shows a minimum around 70 at.% Si content. On the other hand, the Si-Ge alloys shows tendency of concentration dependence as ideal mixture in both total molar volume and the average interatomic distance. These results were discussed taking into account the formation of anisotropic bonds between 3d transition metal and Si atoms, which may induce a spatial expansion in the microscopic scale.
Development and Commercialization of Nanomaterials by the NanoSpraySM Combustion Processing Technology
Authors: Jiang Yongdong , White Marvis , Venugopal Ganesh , Hunt Andrew T. 
Published: April 2013

ABSTRACTnGimat has commercialized a number of nanotech applications based on its core competence of creating low cost high quality nanomaterials. It offers a wide range of nanomaterials as coatings and nanopowders including dispersion form. While being successful in obtaining government R&D funding, nGimat has more than half of revenues from its private industry customers and is profitable. As an example, based on the DOE and DOD SBIR funding, nGimat has successfully developed high performance superhydrophobic coatings on various substrates. The superhydrophobic coatings show high transparency and high durability in addition to high contact angle and low rolling angle. Due to the excellent performance, nGimat signed a license agreement with a major automobile manufacturer to commercialize the superhydrophobic coatings for automobile applications. A few of other applications are also covered, including various nanopowders (including Li-battery based) and nGisulateTM high temperature thin wire coatings.The CCVD (coating NanoSpraySM Combustion process) can be easily scaled up to large substrates and integrated into an existing production line, thus enabling a license business model. The CCVC (nanopowder NanoSpraySM Combustion process) is above 50kg/day capability and will soon yield 100kg/day production rates. Even higher production rates are readily achievable as demand is required. A manufacturing business model is being used for these nanopowder based products and should be internationally competitive even when made in the USA as the market matures