bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Survival after Cardiac Arrest and 3½ Hours of Resuscitation
Authors: Nusbaum Derek M. , Bassett Scott T. , Gregoric Igor D. , Kar Biswajit 
Published: April 2014

Although survival rates after cardiac arrest remain low, new techniques are improving patients' outcomes. We present the case of a 40-year-old man who survived a cardiac arrest that lasted approximately 3½ hours. Resuscitation was performed with strict adherence to American Heart Association/American College of Cardiology Advanced Cardiac Life Support guidelines until bedside extracorporeal membrane oxygenation could be placed. A hypothermia protocol was initiated immediately afterwards. The patient had a full neurologic recovery and was bridged from dual ventricular assist devices to a total artificial heart. On hospital day 160, he underwent orthotopic heart and cadaveric kidney transplantation. On day 179, he was discharged from the hospital in ambulatory condition.
To our knowledge, this is the only reported case in which a patient survived with good neurologic outcomes after a resuscitation that lasted as long as 3½ hours. Documented cases of resuscitation with good recovery after prolonged arrest give hope for improved overall outcomes in the future.
Perioperative Outcomes after On- and Off-Pump Coronary Artery Bypass Grafting
Authors: Bakaeen Faisal G. , Chu Danny , Kelly Rosemary F. , Holman William L. , Jessen Michael E. , Ward Herbert B. 
Published: April 2014

Although numerous reports describe the results of off-pump coronary artery bypass grafting (CABG) at specialized centers and in select patient populations, it remains unclear how off-pump CABG affects real-world patient outcomes. We conducted a large, multicenter observational cohort study of perioperative death and morbidity in on-pump (ON) versus off-pump (OFF) CABG.
We reviewed Veterans Affairs Surgical Quality Improvement Program data for all patients (N=65,097) who underwent isolated CABG from October 1997 through April 2011 (intention-to-treat data were available from 2005 onward). The primary outcome was perioperative (30-day or in-hospital) death; the secondary outcomes were perioperative stroke, dialysis dependence, reoperation for bleeding, mechanical circulatory support, myocardial infarction, ventilator support ≥48 hr, and mediastinitis. Propensity scores calculated from age, 17 preoperative risk factors, and year of surgery were used to match 8,911 OFF with 26,733 ON patients.
In the complete cohort, compared with the ON patients (n=53,468), the OFF patients (n=11,629) had less perioperative death (2.02% vs 2.53%, P=0.0012) and lower incidences of all morbidities except perioperative myocardial infarction. In the matched cohort, perioperative death did not differ significantly between OFF and ON patients (1.94% vs 2.28%, P=0.06), but the OFF group had lower incidences of all morbidities except for perioperative myocardial infarction and mediastinitis. A subgroup intention-to-treat analysis yielded similar but smaller outcome differences between the ON and OFF groups.
Off-pump CABG might be associated with decreased operative morbidity but did not affect operative death, compared with on-pump CABG. Future studies should examine the effect of off-pump CABG on long-term outcomes.
Peripheral structures of relatively hyperbolic groups
Authors: Yang Wen-yuan 
Published: April 2014

Abstract.

In this paper, we introduce and characterize a class of
parabolically extended structures for relatively hyperbolic groups. A characterization of relative quasiconvexity with respect to
parabolically extended structures is obtained. The connection
between the existence of a minimal relatively hyperbolic structure
on a given group and the action on its Floyd boundary is examined. It is shown that Dunwoody's inaccessible group that has no minimal
relatively hyperbolic structure turns out to be acting
non-geometrically finitely on its Floyd boundary.
Weakly-exceptional singularities in higher dimensions
Authors: Cheltsov Ivan , Shramov Constantin 
Published: April 2014

Abstract.

We show that infinitely many Gorenstein weakly-exceptional quotient
singularities exist in all dimensions, we prove
a weak-exceptionality criterion for five-dimensional quotient
singularities, and we find a sufficient condition for being
weakly-exceptional for six-dimensional quotient singularities. The
proof is naturally linked to various classical geometrical
constructions related to subvarieties of small degree in
projective spaces, in particular Bordiga surfaces and Bordiga
threefolds.
Synthesis of new 2- and 3-hydroxyquinoline-4-carboxylic acid derivatives as potential antioxidants
Authors: Massoud Mohammed A. , El Bialy Serry A. , Bayoumi Waleed A. , El Husseiny Walaa M. 
Published: April 2014

Abstract
A new series of 3-aryl-2-hydroxyquinoline-4-carboxylic acids 17a,b, 2-aryl-3-hydroxyquinoline-4-carboxylic acids 12a–d and their derivatives 13–16 and 18–21 were designed, synthesized and evaluated for their antioxidant activity using the ABTS assay method. Compounds 14 and 21a,b showed good antioxidant activity, whereas the remaining compounds displayed mild to moderate activity. All compounds were characterized by physical and spectral data.
Synthesis and molecular docking of indole and carbazole derivatives with potential pharmacological activity
Authors: Kaczor Agnieszka A. , Pihlaja Kalevi , Sinkkonen Jari , Wiinamäki Kirsti , Kronbach Christiane , Unverferth Klaus , Wróbel Tomasz , Stachal Tomasz , Matosiuk Dariusz 
Published: April 2014

Abstract
Indole and carbazole derivatives were designed as non-competitive antagonists of the GluK2 receptor. The synthesized compounds were found to interact with the transduction domain of the receptor. The binding pocket is situated within one receptor subunit.
Exponentially Stagnation Point Flow of Non-Newtonian Nanofluid over an Exponentially Stretching Surface
Authors: Nadeem S. , Sadiq M. A. , Choi Jung-il , Lee Changhoon 
Published: April 2014

Abstract
The steady stagnation point flow of Jeffrey nanofluid over an exponential stretching surface under the boundary layer assumptions is discussed analytically. The transport equations include the effects of Brownian motion and thermophoresis. The boundary layer coupled partial differential equations of Jeffrey nanofluid are simplified with the help of suitable semi-similar transformations. The reduced equations are then solved analytically with the help of homotopy analysis method (HAM). The convergence of HAM solutions have been discussed by plotting h-curve. The expressions for velocity, temperature and nano particle volume fraction are computed for some values of the parameters namely, Jeffrey relaxation and retardation parameters B and λ
1, stretching/ shrinking parameter A, suction injection parameter vw
, Lewis number Le, the Brownian motion Nb, thermophoresis parameter Nt and Prandtl number Pr.
Open problems in Petri net modeling and simulation of biological
systems
Authors: Chen Ming , Hofestädt Ralf 
Published: April 2014

Abstract
Petri net methodology has been widely used for modeling and
simulation of biological systems due to its intuitive graphical
representation and mathematical power for concurrent systems. In this
article, some of the major problems arising in this field are addressed,
ongoing progresses are discussed, and possible solutions are suggested.
Convergence of posteriors for structurally non-identified problems using results from the theory of inverse problems
Authors: Radde Nicole E. , Offtermatt Jonas 
Published: April 2014

Abstract.
We consider convergence of the posterior distribution in a Bayesian parameter estimation framework in the large sample size limit for structurally non-identified problems. These belong to the class of ill-posed problems, and the large sample theory is not applicable here. In particular, the influence of the prior distribution does not vanish in the large sample size limit. We review recent results in this area and present ideas inspired from the theory of ill-posed inverse problems that can be used towards a more general concept of posterior convergence for non-identified problems.
Geometric measures of finite carbon nanotube molecules: a proposal for length index and filling indexes
Authors: Matsuno Taisuke , Naito Hisashi , Hitosugi Shunpei , Sato Sota , Kotani Motoko , Isobe Hiroyuki 
Published: April 2014

Abstract
The structural chemistry of carbon nanotube molecules has been of increasing interest, as molecular entities with fundamental structures of finite nanotube molecules have emerged. For the new field to be developed further, appropriate structural descriptors are necessary as the basis for discussion. In this paper, we propose new geometric descriptors for finite nanotube molecules. Based on popular existing descriptors, these new descriptors provide geometric measures for length and bond- and atom-filling in tubular molecular structures.
Simulation und Auswahl von psychometrischen Verfahren zur Ermittlung von Kennwerten menschlicher Wahrnehmung
Authors: Hatzfeld Christian , Werthschützky Roland 
Published: April 2014

Zusammenfassung
Zur Bestimmung von Wahrnehmungskennwerten des Menschen werden psychometrische Verfahren verwendet. Diese werden wiederum in einer Vielzahl von Anwendungen zur Optimierung und Anpassung von Systemen zur Mensch-Technik-Interaktion benötigt. Zur Auswahl eines geeigneten Verfahrens werden in diesem Beitrag unterschiedliche psychometrische Verfahren, ein Rahmenwerk für die Simulation solcher Messverfahren und mögliche objektive Bewertungskriterien vorgestellt. Die Leistungsfähigkeit der Simulation wird an Beispielen zum Methodenvergleich und dem Einfluss einzelner Konfigurationsparameter gezeigt.
Modellbasierte deflektometrische Messung von transparenten Objekten
Authors: Fischer Marc , Petz Marcus , Tutsch Rainer 
Published: April 2014

Zusammenfassung
Für die Messung der Geometrie transparenter Objekte stehen eine Reihe
etablierter optischer Messverfahren zur Verfügung. Bei diesen Verfahren
werden im Allgemeinen die Vorder- und die Rückfläche eines
Prüflings getrennt in Reflexion gemessen. Dieses Vorgehen birgt einige
Nachteile, insbesondere geht der geometrische Zusammenhang zwischen den
Flächen zunächst verloren und muss durch aufwendige Kalibrierung der
Systemgeometrie oder durch zusätzliche Messungen, z. B. mit einem
Koordinatenmessgerät, wieder hergestellt werden. Als Alternative dazu
wird im Rahmen der vorliegenden Arbeit eine deflektometrische Messung der
Lichtstrahlverläufe durch den Prüfling in Transmission mit einer
anschließenden modellbasierten Rekonstruktion der Prüflingsgeometrie
vorgeschlagen. Es werden unterschiedliche Rekonstruktionsansätze
vorgestellt und diskutiert und die Leistungsfähigkeit des Verfahrens
wird anhand einer Beispielmessung eines asphärischen Brillenglasrohlings
demonstriert.
Bile Salts Aggregation Behavior at Various Temperatures under the Influence of Amphiphilic Drug Imipramine Hydrochloride in Aqueous Medium
Authors: Rub Malik Abdul , Sheikh Mohmad Shafi , Khan Farah , Khan Sher Bahadar , Asiri Abdullah M. 
Published: April 2014

Abstract
The aim of this investigation is the characterization of interaction
of different bile salts – sodium cholate (NaC), sodium deoxycholate
(NaDC) and sodium taurocholate (NaTC) with amphiphilic drug imipramine
hydrochloride (IMP) because the bioavailability of lipophilic drugs
following oral administration strongly depends on the presence of food
components. These bile salts improve the bioavailability of poorly
absorbable drugs by lowering the surface tension of the
gastrointestinal fluid or by solubilization. The interactions in the
binary systems (drug and bile salts) were studied by determining
various physicochemical parameters like critical micelle concentration
(cmc), ideal cmc (cmcid
),
counterion dissociation (g), standard Gibbs free energy (ΔG
m
0), enthalpy (ΔH
m
0), and
entropy of micellization (ΔS
m
0), micellar
mole fractions of bile salt (X
1
Rub, X
1
M,
X
1
Rod), micellar mole fraction of bile salt in ideal
state (X
1
id), interaction parameter (β),
activity coefficients (f
1, f
2), and excess free energy of
mixing (ΔG
ex) of the mixed micelles using
Clint's, Rubingh's, Motomura's and Rodenas's theories for mixed
micellar systems. All the results point out synergism and attractive
interactions in the mixed systems of drug and bile salts. NaDC is more
effective in reducing the cmc of drug IMP as compared to NaC
and NaTC because it binds strongly to the positively charged drug ions
and reduces the head group area more in comparison to other. This
study will give insight into the selection of drugs in different
applications as their properties get modified by interaction with bile
salts, thus influencing their solution behavior which, in turn,
modifying the phase-forming behavior, microemulsion, clouding
phenomenon, besides solubilization. The modification of solubilization
ability in a medium can be exploited for the purpose of selective
encapsulation and release.
Impact of the FITKids Physical Activity Intervention on Adiposity in Prepubertal Children
Authors: Khan Naiman A. , Raine Lauren B. , Drollette Eric S. , Scudder Mark R. , Pontifex Matthew B. , Castelli Darla M. , Donovan Sharon M. , Evans Ellen M. , Hillman Charles H. 
Published: April 2014

OBJECTIVE:
To investigate the effect of a 9-month physical activity intervention on cardiorespiratory fitness and adiposity among prepubertal children.

METHODS:
Prepubertal children (8- to 9-year-olds, N = 220, 103 girls) were randomly assigned to a 9-month physical activity intervention or a control group. The intervention provided 70 minutes (5 days/week) of moderate to vigorous physical activity. Maximum oxygen consumption (Vo2max percentile) and dual-energy radiograph absorptiometry measured cardiorespiratory fitness and adiposity, respectively. Intention-to-treat analysis was performed to assess baseline and follow-up cardiorespiratory fitness, percentage fat mass (%FM), percentage central fat mass (%CFM), and estimated visceral adipose tissue (VAT) area.

RESULTS:
The intervention group increased in cardiorespiratory fitness (5.4th percentile; 95% confidence interval [CI], 1.8 to 8.9) and decreased in %FM (−0.7%; 95% CI, −1.1 to −0.4) and %CFM (−1.3%; 95% CI, −1.9 to −0.7). Reductions in %FM were evident for both nonoverweight (−0.62%; 95% CI, −1.07 to −0.17) and overweight or obese (−0.86%; 95% CI,−1.46 to −0.25) intervention participants. Conversely, the control group displayed no change in cardiorespiratory fitness while exhibiting increases in %FM (0.4%; 95% CI, 0.1 to 0.7), %CFM (0.6; 95% CI, 0.1 to 1.1), and VAT area (3.0 cm2; 95% CI, 1.6 to 4.4). Nonoverweight control participants increased in %FM (0.52%; 95% CI, 0.13 to 0.91), and their overweight and obese counterparts increased in VAT (4.76 cm2; 95% CI, 1.90 to 7.63).

CONCLUSIONS:
The physical activity intervention improved cardiorespiratory fitness, reduced %FM, and prevented accumulation of %CFM among prepubertal children with varying adiposity levels. These findings provide support for daily physical activity recommendations to prevent excess fat mass accumulation in childhood.
Office-Based Preventive Dental Program and Statewide Trends in Dental Caries
Authors: Achembong Leo N. , Kranz Ashley M. , Rozier R. Gary 
Published: April 2014

OBJECTIVES:
To evaluate the impact of a North Carolina Medicaid preventive dentistry program in primary care medical offices (Into the Mouths of Babes Program [IMBP]) on decayed, missing, and filled teeth (dmft) of kindergarten students statewide and in schools with a large proportion of students from low-income families.

METHODS:
An ecologic study using panel data of 920 505 kindergarten students with 11 694 school-year observations examined the effect of the IMBP on dmft scores from 1998 to 2009. Ordinary least squares regression with fixed effects determined the association between IMBP visits per child 0 to 4 years of age per county and mean dmft scores per kindergarten student per school, controlling for school-level poverty and ethnicity, county-level Medicaid enrollment, and supply of dentists and physicians.

RESULTS:
Mean dmft per kindergarten student per school increased from 1.53 in 1998 to 1.84 in 2004, then decreased to 1.59 in 2009. The mean number of IMBP visits per child 0 to 4 years of age per county increased from 0.01 in 2000 to 0.22 in 2009. A 1-unit increase in IMBP visits per county was associated with a 0.248 (95% confidence interval, −0.40 to −0.10) decrease in dmft per kindergarten student per school. For schools with more students at high risk for dental disease, a 1-unit increase in IMBP visits was associated with a 0.320 (95% confidence interval, −0.55 to −0.09) decrease in dmft.

CONCLUSIONS:
IMBP reduced dental caries among targeted vulnerable children, which helped reduce oral health disparities among preschool-aged children in North Carolina.
Trends in the Prevalence of Ketoacidosis at Diabetes Diagnosis: The SEARCH for Diabetes in Youth Study
Authors: Dabelea Dana , Rewers Arleta , Stafford Jeanette M. , Standiford Debra A. , Lawrence Jean M. , Saydah Sharon , Imperatore Giuseppina , D’Agostino Ralph B. , Mayer-Davis Elizabeth J. , Pihoker Catherine 
Published: April 2014

OBJECTIVE:
To estimate temporal changes in the prevalence of diabetic ketoacidosis (DKA) at diagnosis of type 1 or type 2 diabetes in youth and to explore factors associated with its occurrence.

METHODS:
Five centers identified incident cases of diabetes among youth aged 0 to 19 years starting in 2002. DKA presence was defined as a bicarbonate level &lt;15 mmol/L and/or a pH &lt;7.25 (venous) or &lt;7.30 (arterial or capillary) or mention of DKA in the medical records. We assessed trends in the prevalence of DKA over 3 time periods (2002–2003, 2004–2005, and 2008–2010). Logistic regression was used to determine factors associated with DKA.

RESULTS:
In youth with type 1 diabetes (n = 5615), the prevalence of DKA was high and stable over time (30.2% in 2002–2003, 29.1% in 2004–2005, and 31.1% in 2008–2010; P for trend = .42). Higher prevalence was associated with younger age at diagnosis (P &lt; .0001), minority race/ethnicity (P = .019), income (P = .019), and lack of private health insurance (P = 008). Among youth with type 2 diabetes (n = 1425), DKA prevalence decreased from 11.7% in 2002–2003 to 5.7% in 2008–2010 (P for trend = .005). Higher prevalence was associated with younger age at diagnosis (P = .001), minority race/ethnicity (P = .013), and male gender (P = .001).

CONCLUSIONS:
The frequency of DKA in youth with type 1 diabetes, although stable, remains high, indicating a persistent need for increased awareness of signs and symptoms of diabetes and better access to health care. In youth with type 2 diabetes, DKA at onset is less common and is decreasing over time.
Clinical Phenotype of Scabies by Age
Authors: Boralevi Franck , Diallo Abou , Miquel Juliette , Guerin-Moreau Morgane , Bessis Didier , Chiavérini Christine , Plantin Patrice , Hubiche Thomas , Maruani Annabel , Lassalle Martin , Boursault Lucile , Ezzedine Khaled 
Published: April 2014

OBJECTIVE:
Scabies has a clinical presentation that seems to vary according to age. We conducted a prospective study with the goal of delineating the clinical presentation of the disease into 3 groups of age: infants, &lt;2 years; children, 2 to 15 years; and adults, &gt;15 years.

METHODS:
This trial was a prospective, multicenter observational study in consecutive patients with a confirmed diagnosis of scabies who were seen in 13 French Departments of Dermatology and Pediatric Dermatology between April 2010 and April 2011. A standardized questionnaire was completed for each patient. To identify factors associated with patient age, comparisons between the 3 age groups were conducted by using univariate and multivariate multinomial logistic regression analyses.

RESULTS:
A total of 323 individuals were included; the gender ratio (female:male) was 1.2:1. In univariate analysis, infants were more likely to have facial involvement. In multivariate logistic regression, relapse was more frequent in children (odds ratio [OR]: 2.45 [95% confidence interval (CI):1.23–4.88]) and infants (OR: 3.26 [95% CI: 1.38–7.71]). In addition, family members with itch (OR: 2.47 [95% CI: 1.04–5.89]), plantar (OR: 20.57 [95% CI: 7.22–58.60]), and scalp (OR: 16.94 [95% CI: 3.70–77.51]) involvement were also found to be independently associated with the age group &lt;2 years.

CONCLUSIONS:
There is a specific clinical presentation of scabies in infants and children. Taking into account these specificities may be helpful for the early diagnosis and the identification of cases to prevent the propagation of the disease.
Withholding or Termination of Resuscitation in Pediatric Out-of-Hospital Traumatic Cardiopulmonary Arrest
Authors:   AMERICAN COLLEGE OF SURGEONS Committee on Trauma,   AMERICAN COLLEGE OF EMERGENCY PHYSICIANS Pediatric Emergency Medicine Committee,   NATIONAL ASSOCIATION OF EMS PHYSICIANS,   AMERICAN ACADEMY OF PEDIATRICS Committee on Pediatric Emergency Medicine, Fallat Mary E. , Cooper Arthur , Salomone Jeffrey , Mooney David , Scherer Tres , Wesson David , Bulgar Eileen , Adelson P. David , Benjamin Lee , Gerardi Michael , Barata Isabel A. , Arms Joseph , Alade Kiyetta , Avarello Jahn T. , Baldwin Steven , Brown Kathleen , Cantor Richard M. , Cohen Ariel , Dietrich Ann Marie , Eakin Paul J. , Gausche-Hill Marianne , Graham Charles J. , Holtzman Douglas K. , Hom Jeffrey , Ishimine Paul , Jinivizian Hasmig , Joseph Madeline , Mehta Sanjay , Ojo Aderonke , Paul Audrey Z. , Pauze Denis R. , Pearson Nadia M. , Rosen Brett , Russell William S. , Saijinejad Mohsen , Schwartz Gerald R. , Sloas Andrew , Swenson Orel , Valente Jonathan H. , Waseem Muhammad , Whiteman Paula J. , Woolridge Dale , Brown Kathleen , Sahni Ritu , Shook Joan E. , Ackerman Alice D. , Chun Thomas H. , Conners Gregory P. , Dudley Nanette C. , Fuchs Susan M. , Gorelick Marc H. , Lane Natalie E. , Moore Brian R. , Wright Joseph L. 
Published: April 2014

This Policy Statement was reaffirmed June 2020.
This multiorganizational literature review was undertaken to provide an evidence base for determining whether recommendations for out-of-hospital termination of resuscitation could be made for children who are victims of traumatic cardiopulmonary arrest. Although there is increasing acceptance of out-of-hospital termination of resuscitation for adult traumatic cardiopulmonary arrest when there is no expectation of a good outcome, children are routinely excluded from state termination-of-resuscitation protocols. The decision to withhold resuscitative efforts in a child under specific circumstances (decapitation or dependent lividity, rigor mortis, etc) is reasonable. If there is any doubt as to the circumstances or timing of the traumatic cardiopulmonary arrest, under the current status of limiting termination of resuscitation in the field to persons older than 18 years in most states, resuscitation should be initiated and continued until arrival to the appropriate facility. If the patient has arrested, resuscitation has already exceeded 30 minutes, and the nearest facility is more than 30 minutes away, involvement of parents and family of these children in the decision-making process with assistance and guidance from medical professionals should be considered as part of an emphasis on family-centered care because the evidence suggests that either death or a poor outcome is inevitable.