bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolving dynamics of the relationship between US core inflation and unemployment
Authors: Putnam Bluford H. , Azzarello Samantha 
Published: February 2015

AbstractLabor market dynamics in the US are changing due to long‐term factors including decelerating labor force growth, rising age of the labor force, and the rapid advance of e‐commerce, as well as the one‐time downward adjustment during 2009–2013 of the size of state and local government work forces. We discuss some of the controversies revolving around how to analyze labor markets in this dynamic environment from the perspective of monetary policymaking, given the dual mandate of the Federal Reserve to encourage both full employment and price stability.Our statistical research documents the changing association between US unemployment and core inflation. There was a perceived trade‐off between inflation and unemployment in the 1950s and 1960s that gave way to stagflation in the 1970s, when both unemployment and inflation were rising. The 1980s were a transition period where the trade‐off was perceived to have returned. This trade‐off has not been so clear, however, when one looks at the last twenty years. Since 1995, a period of stable and low inflation was consistently observed despite considerable cycles in the unemployment rate.Our theoretical discussion provides a dynamic interpretation of the shifting nature of labor markets, with the objective of pointing the way for future research while highlighting crucial differences in possible interpretations that could fuel debate, both inside and outside the Fed, over how the Fed should manage its dual mandate. The dynamic changes being seen in US labor markets all suggest that the effectiveness of monetary policy to encourage full employment may be vastly overstated. If this interpretation is correct, the Fed may need to reconsider how to manage its dual mandate and react less aggressively to perceived labor slack that may be due to longer‐term structural shifts over which the Fed has no influence.
Positive Association of D Allele of ACE Gene With High Altitude Pulmonary Edema in Indian Population
Authors: Bhagi Shuchi , Srivastava Swati , Tomar Arvind , Bala Singh Shashi , Sarkar Soma 
Published: February 2015

Objective High altitude pulmonary edema (HAPE) is a potentially fatal high altitude illness occurring as a result of hypobaric hypoxia with an unknown underlying genetic mechanism. Recent studies have shown a possible association between HAPE and polymorphisms in genes of the renin-angiotensin-aldosterone system (RAAS), which play a key role in sensitivity of an individual toward HAPE. Methods For the present investigation, study groups consisted of HAPE patients (HAPE) and acclimatized control subjects (rCON). Four single-nucleotide polymorphisms (SNPs) were genotyped using restriction fragment length polymorphism (RFLP) analysis in genes of the RAAS pathway, specifically, renin ( REN) C(–4063)T (rs41317140) and RENi8–83 (rs2368564), angiotensin ( AGT) M(235)T (rs699), and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) (rs1799752). Results Only the I/D polymorphism of the ACE gene showed a significant difference between the HAPE and rCON groups. The frequency of the D allele was found to be significantly higher in the HAPE group. Arterial oxygen saturation levels were significantly lower in the HAPE group compared with the rCON group and also decreased in the I/D and D/D genotypes compared with the I/I genotype in these groups. The other polymorphisms occurring in the REN and AGT genes were not significantly different between the 2 groups. Conclusions These findings demonstrate a possible association of the I/D polymorphism of the ACE gene with the development of HAPE, with D/D being the at-risk genotype.
Global Health Security Demands a Strong International Health Regulations Treaty and Leadership From a Highly Resourced World Health Organization
Authors: Burkle Frederick M. 
Published: February 2015

AbstractIf the Ebola tragedy of West Africa has taught us anything, it should be that the 2005 International Health Regulations (IHR) Treaty, which gave unprecedented authority to the World Health Organization (WHO) to provide global public health security during public health emergencies of international concern, has fallen severely short of its original goal. After encouraging successes with the 2003 severe acute respiratory syndrome (SARS) pandemic, the intent of the legally binding Treaty to improve the capacity of all countries to detect, assess, notify, and respond to public health threats has shamefully lapsed. Despite the granting of 2-year extensions in 2012 to countries to meet core surveillance and response requirements, less than 20% of countries have complied. Today it is not realistic to expect that these gaps will be solved or narrowed in the foreseeable future by the IHR or the WHO alone under current provisions. The unfortunate failures that culminated in an inadequate response to the Ebola epidemic in West Africa are multifactorial, including funding, staffing, and poor leadership decisions, but all are reversible. A rush by the Global Health Security Agenda partners to fill critical gaps in administrative and operational areas has been crucial in the short term, but questions remain as to the real priorities of the G20 as time elapses and critical gaps in public health protections and infrastructure take precedence over the economic and security needs of the developed world. The response from the Global Outbreak Alert and Response Network and foreign medical teams to Ebola proved indispensable to global health security, but both deserve stronger strategic capacity support and institutional status under the WHO leadership granted by the IHR Treaty. Treaties are the most successful means the world has in preventing, preparing for, and controlling epidemics in an increasingly globalized world. Other options are not sustainable. Given the gravity of ongoing failed treaty management, the slow and incomplete process of reform, the magnitude and complexity of infectious disease outbreaks, and the rising severity of public health emergencies, a recommitment must be made to complete and restore the original mandates as a collaborative and coordinated global network responsibility, not one left to the actions of individual countries. The bottom line is that the global community can no longer tolerate an ineffectual and passive international response system. As such, this Treaty has the potential to become one of the most effective treaties for crisis response and risk reduction worldwide. Practitioners and health decision-makers worldwide must break their silence and advocate for a stronger Treaty and a return of WHO authority. (Disaster Med Public Health Preparedness. 2015;9:568–580)
Reviving the Remains of Colonization – The Belgian Colonial Archives in Brussels
Authors: Piret Bérengère 
Published: February 2015

AbstractSince 1997, all the archives of Belgian Congo are deposited at the Belgian Ministry of Foreign Affairs in Brussels and are opened up the public. For more than fifteen years, researchers have consulted and scrutinized its documents produced by the colonial authorities between 1908 and 1960. Still several collections have not been explored. This article relates of the history and the organization of the archives of Belgian Congo.
Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour
Authors: Winther Gudrun , Pyndt Jørgensen Betina M , Elfving Betina , Nielsen Denis Sandris , Kihl Pernille , Lund Sten , Sørensen Dorte Bratbo , Wegener Gregers 
Published: February 2015

ObjectiveGut microbiota (GM) has previously been associated with alterations in rodent behaviour, and since the GM is affected by the diet, the composition of the diet may be an important factor contributing to behavioural changes. Interestingly, a magnesium restricted diet has been shown to induce anxiety and depressive-like behaviour in humans and rodents, and it could be suggested that magnesium deficiency may mediate the effects through an altered GM.MethodsThe present study therefore fed C57BL/6 mice with a standard diet or a magnesium deficient diet (MgD) for 6 weeks, followed by behavioural testing in the forced swim test (FST) to evaluate depressive-like behaviour. An intraperitoneal glucose tolerance test (GTT) was performed 2 day after the FST to assess metabolic alterations. Neuroinflammatory markers were analysed from hippocampus. GM composition was analysed and correlated to the behaviour and hippocampal markers.ResultsIt was found that mice exposed to MgD for 6 weeks were more immobile than control mice in the FST, suggesting an increased depressive-like behaviour. No significant difference was detected in the GTT. GM composition correlated positively with the behaviour of undisturbed C57BL/6 mice, feeding MgD diet altered the microbial composition. The altered GM correlated positively to the hippocampal interleukin-6.ConclusionIn conclusion, we hypothesise that imbalances of the microbiota–gut–brain axis induced by consuming a MgD diet, contributes to the development of depressive-like behaviour.
The combined impact of adherence to five lifestyle factors on all-cause, cancer and cardiovascular mortality: a prospective cohort study among Danish men and women
Authors: Petersen Kristina E. N. , Johnsen Nina F. , Olsen Anja , Albieri Vanna , Olsen Lise K. H. , Dragsted Lars O. , Overvad Kim , Tjønneland Anne , Egeberg Rikke 
Published: February 2015

Individual lifestyle factors have been associated with lifestyle diseases and premature mortality by an accumulating body of evidence. The impact of a combination of lifestyle factors on mortality has been investigated in several studies, but few have applied a simple index taking national guidelines into account. The objective of the present prospective cohort study was to investigate the combined impact of adherence to five lifestyle factors (smoking, alcohol intake, physical activity, waist circumference and diet) on all-cause, cancer and cardiovascular mortality based on international and national health recommendations. A Cox proportional hazards model was used to estimate hazard ratios (HR) with 95 % CI. During a median follow-up of 14 years, 3941 men and 2827 women died. Among men, adherence to one additional health recommendation was associated with an adjusted HR of 0·73 (95 % CI 0·71, 0·75) for all-cause mortality, 0·74 (95 % CI 0·71, 0·78) for cancer mortality and 0·70 (95 % CI 0·65, 0·75) for cardiovascular mortality. Among women, the corresponding HR was 0·72 (95 % CI 0·70, 0·75) for all-cause mortality, 0·76 (95 % CI 0·73, 0·80) for cancer mortality and 0·63 (95 % CI 0·57, 0·70) for cardiovascular mortality. In the present study, adherence to merely one additional health recommendation had a protective effect on mortality risk, indicating a huge potential in enhancing healthy lifestyle behaviours of the population.
Environmental predictors of diarrhoeal infection for rural and urban communities in south India in children and adults
Authors: KATTULA D. , FRANCIS M. R. , KULINKINA A. , SARKAR R. , MOHAN V. R. , BABJI S. , WARD H. D. , KANG G. , BALRAJ V. , NAUMOVA E. N. 
Published: February 2015

SUMMARYDiarrhoeal diseases are major causes of morbidity and mortality in developing countries. This longitudinal study aimed to identify controllable environmental drivers of intestinal infections amidst a highly contaminated drinking water supply in urban slums and villages of Vellore, Tamil Nadu in southern India. Three hundred households with children (<5 years) residing in two semi-urban slums and three villages were visited weekly for 12–18 months to monitor gastrointestinal morbidity. Households were surveyed at baseline to obtain information on environmental and behavioural factors relevant to diarrhoea. There were 258 diarrhoeal episodes during the follow-up period, resulting in an overall incidence rate of 0·12 episodes/person-year. Incidence and longitudinal prevalence rates of diarrhoea were twofold higher in the slums compared to rural communities (P < 0·0002). Regardless of study site, diarrhoeal incidence was highest in infants (<1 year) at 1·07 episodes/person-year, and decreased gradually with increasing age. Increasing diarrhoeal rates were associated with presence of children (<5 years), domesticated animals and low socioeconomic status. In rural communities, open-field defecation was associated with diarrhoea in young children. This study demonstrates the contribution of site-specific environmental and behavioural factors in influencing endemic rates of urban and rural diarrhoea in a region with highly contaminated drinking water.
Spatial–temporal patterns of surface melting observed over Antarctic ice shelves using scatterometer data
Authors: Oza Sandip Rashmikant 
Published: February 2015

AbstractIce shelves fringing Antarctica are sensitive indicators of climate change due to the direct interface with the atmosphere and ocean. Meltwater induced by atmospheric warming percolates from the surface into hydrofractures and affects shelf stability. Surface melting reduces the microwave backscattering; thus backscatter data is useful in melt monitoring. The Ku-band scatterometer derived melting index (MI) was utilized to assess the decadal (2000–10) variability observed over Antarctic ice shelves. The low intensity melting observed over large ice shelves and high intensity melting observed over the Larsen, Amery, West and Shackleton ice shelves are discussed. A correlation of around 93% was observed between MI variation and rift propagation over Amery Ice Shelf. The El Niño and the Southern Oscillation (ENSO) correlation with MI was also investigated. The paper highlights that scatterometer derived information has the potential to assess meltwater production and rift propagation.
Deforestation slowdown in the Brazilian Amazon: prices or policies?
Authors: Assunção Juliano , Gandour Clarissa , Rocha Rudi 
Published: February 2015

AbstractThis paper investigates the contribution of agricultural output prices and policies to the reduction in Amazon deforestation in the 2000s. Based on a panel of Amazon municipalities from 2002 through 2009, we first show that deforestation responded to agricultural output prices. After controlling for price effects, we find that conservation policies implemented beginning in 2004 and 2008 significantly contributed to the curbing of deforestation. Counterfactual simulations suggest that conservation policies avoided approximately 73,000 km2of deforestation, or 56 per cent of total forest clearings that would have occurred from 2005 through 2009 had the policies adopted beginning in 2004 and 2008 not been introduced. This is equivalent to an avoided loss of 2.7 billion tonnes of stored carbon dioxide.
Human Rights Day after the ‘breakthrough’: celebrating the Universal Declaration of Human Rights at the United Nations in 1978 and 1988
Authors: Burke Roland 
Published: February 2015

AbstractThis article examines the impact of the late 1970s ‘breakthrough’ in human rights, as it was registered within the United Nations. It analyses the debates on human rights at the thirtieth anniversary of the Universal Declaration of Human Rights, in December 1978, and those a decade later. These two moments, among the few that invited explicit reflection from states on the meaning of human rights, and of their universality, reveal that the effects of the ‘breakthrough’ arrived at the UN after a long period of latency. Even by 1988, their manifestation was only partial, and often contradictory. The profound gap between the efflorescence in the NGO movement and the depressing stasis, or worse, elsewhere suggests the need for a more complex periodization of the 1970s as an era of decisive triumph in the ascent of human rights.
Engineering inter-imperialism: American miners and the transformation of global mining, 1871–1910
Authors: Tuffnell Stephen 
Published: February 2015

AbstractThis article examines the transnational circulation of American mine engineers between the United States, southern Africa, and the Americas in the late nineteenth century. Technology and knowledge was diffused worldwide with the circulation of American engineers who styled themselves as expert race managers as they compared the labour practices of mines across the world. The article's focus is the extension of the United States’ global footprint to South Africa, where an expatriate ‘colony’ of American engineers created a resilient form of Anglo-American inter-imperial collaboration. As they worked the Rand, American engineers made transnational comparisons of South African and North and South American mines. In the process, they led a global discussion of the efficiency of mining labour that reified white management of other races. After leaving the Rand, American engineers migrated across the globe, many to Mexico, where the interwoven networks of expert knowledge, industrial capitalism, and transnational race-making that characterized late nineteenth-century global mining followed.
Wie effektiv sind Maßnahmen zur Förderung der phonologischen Bewusstheit?
Authors: Fischer Melanie Y. , Pfost Maximilian 
Published: February 2015

Die phonologische Bewusstheit wird vielfach als notwendige Voraussetzung für den Schriftspracherwerb gesehen und stellt daher einen möglichen Ansatzpunkt für intervenierende Maßnahmen dar. Die Wirksamkeit von Trainingsprogrammen wurde jedoch bislang im deutschen Sprachraum nicht zusammenfassend geprüft. Im Rahmen der vorliegenden Arbeit wurde geprüft, ob ein Training phonologischer Bewusstheit für deutschsprachige Kinder effektiv ist, um deren Schriftspracherwerb zu fördern. Insgesamt wurden 19 Arbeiten, welche 22 Trainings-Kontrollgruppen-Vergleiche enthielten, durch eine systematische Literaturrecherche identifiziert und deren Ergebnisse meta-analytisch integriert. Für Maße der phonologischen Bewusstheit zeigte sich ein mittlerer, statistisch bedeutsamer Trainingseffekt in Höhe von d = 0.36. Ebenso waren im Mittel kurzfristige (d = 0.21) sowie langfristige (d = 0.14) signifikante Transfereffekte für das Lesen und Rechtschreiben nachweisbar. Im Vergleich zu Ergebnissen aus dem englischen Sprachraum zeigen die hier integrierten Befunde eine geringere Wirksamkeit von Fördermaßnahmen der phonologischen Bewusstheit für den Schriftspracherwerb im Deutschen. Systematische Orthographieunterschiede stellen einen Erklärungsansatz für diese divergierende Befundlage dar.
Validated predictive modelling of the environmental resistome
Authors: Amos Gregory C A , Gozzard Emma , Carter Charlotte E , Mead Andrew , Bowes Mike J , Hawkey Peter M , Zhang Lihong , Singer Andrew C , Gaze William H , Wellington Elizabeth M H 
Published: February 2015

Abstract
Multi-drug-resistant bacteria pose a significant threat to public health. The role of the environment in the overall rise in antibiotic-resistant infections and risk to humans is largely unknown. This study aimed to evaluate drivers of antibiotic-resistance levels across the River Thames catchment, model key biotic, spatial and chemical variables and produce predictive models for future risk assessment. Sediment samples from 13 sites across the River Thames basin were taken at four time points across 2011 and 2012. Samples were analysed for class 1 integron prevalence and enumeration of third-generation cephalosporin-resistant bacteria. Class 1 integron prevalence was validated as a molecular marker of antibiotic resistance; levels of resistance showed significant geospatial and temporal variation. The main explanatory variables of resistance levels at each sample site were the number, proximity, size and type of surrounding wastewater-treatment plants. Model 1 revealed treatment plants accounted for 49.5% of the variance in resistance levels. Other contributing factors were extent of different surrounding land cover types (for example, Neutral Grassland), temporal patterns and prior rainfall; when modelling all variables the resulting model (Model 2) could explain 82.9% of variations in resistance levels in the whole catchment. Chemical analyses correlated with key indicators of treatment plant effluent and a model (Model 3) was generated based on water quality parameters (contaminant and macro- and micro-nutrient levels). Model 2 was beta tested on independent sites and explained over 78% of the variation in integron prevalence showing a significant predictive ability. We believe all models in this study are highly useful tools for informing and prioritising mitigation strategies to reduce the environmental resistome.
How deeply does your mutant sleep? Probing arousal to better understand sleep defects in Drosophila
Authors: Faville R. , Kottler B. , Goodhill G. J. , Shaw P. J. , van Swinderen B. 
Published: February 2015

AbstractThe fruitfly, Drosophila melanogaster, has become a critical model system for investigating sleep functions. Most studies use duration of inactivity to measure sleep. However, a defining criterion for sleep is decreased behavioral responsiveness to stimuli. Here we introduce the Drosophila ARousal Tracking system (DART), an integrated platform for efficiently tracking and probing arousal levels in animals. This video-based platform delivers positional and locomotion data, behavioral responsiveness to stimuli, sleep intensity measures and homeostatic regulation effects – all in one combined system. We show how insight into dynamically changing arousal thresholds is crucial for any sleep study in flies. We first find that arousal probing uncovers different sleep intensity profiles among related genetic background strains previously assumed to have equivalent sleep patterns. We then show how sleep duration and sleep intensity can be uncoupled, with distinct manipulations of dopamine function producing opposite effects on sleep duration but similar sleep intensity defects. We conclude by providing a multi-dimensional assessment of combined arousal and locomotion metrics in the mutant and background strains. Our approach opens the door for deeper insights into mechanisms of sleep regulation and provides a new method for investigating the role of different genetic manipulations in controlling sleep and arousal.
iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death
Authors: Notari Mario , Hu Ying , Sutendra Gopinath , Dedeić Zinaida , Lu Min , Dupays Laurent , Yavari Arash , Carr Carolyn A. , Zhong Shan , Opel Aaisha , Tinker Andrew , Clarke Kieran , Watkins Hugh , Ferguson David J. P. , Kelsell David P. , de Noronha Sofia , Sheppard Mary N. , Hollinshead Mike , Mohun Timothy J. , Lu Xin 
Published: February 2015

Significance
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease that is selective to the right side of the heart and results in heart failure and sudden death. Genetic defects in desmosome components account for approximately 50% of human ARVC cases; in the other 50% of patients, however, the causes remain unknown. We show that inhibitor of apoptosis-stimulating protein of p53 (iASPP) is an important regulator of desmosomes. It interacts with desmoplakin and desmin in cardiomyocytes and regulates desmosome integrity and intermediate filaments. iASPP-deficient mice display pathological features of ARVC and die of sudden death. In human ARVC patients, cardiomyocytes exhibit reduced levels of iASPP at the cell junctions, suggesting that iASPP may be critical in ARVC pathogenesis.