bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient satisfaction with in-centre haemodialysis care: an international survey
Authors: Palmer Suetonia C , de Berardis Giorgia , Craig Jonathan C , Tong Allison , Tonelli Marcello , Pellegrini Fabio , Ruospo Marinella , Hegbrant Jörgen , Wollheim Charlotta , Celia Eduardo , Gelfman Ruben , Ferrari Juan Nin , Törok Marietta , Murgo Marco , Leal Miguel , Bednarek-Skublewska Anna , Dulawa Jan , Strippoli Giovanni F M 
Published: May 2014

ObjectivesTo evaluate patient experiences of specific aspects of haemodialysis care across several countries.DesignCross-sectional survey using the Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) questionnaire.SettingHaemodialysis clinics within a single provider in Europe and South America.Participants2748 adults treated in haemodialysis.Primary and secondary outcomesThe primary outcome was patient satisfaction with overall care. Secondary outcomes included patient experiences of individual aspects of dialysis care.Results2145 (78.1%) adults responded to the questionnaire. Fewer than half (46.5% (95% CI 44.5% to 48.6%)) rated their overall care as excellent. Global perceptions of care were uninfluenced by most respondent characteristics except age and depressive symptoms; older respondents were less critical of their care (adjusted OR for excellent rating 1.44 (1.01 to 2.04)) and those with depressive symptoms were less satisfied (0.56 (0.44 to 0.71)). Aspects of care that respondents most frequently ranked as excellent were staff attention to dialysis vascular access (54% (52% to 56%)); caring of nurses (53% (51% to 55%)); staff responsiveness to pain or discomfort (51% (49% to 53%)); caring, helpfulness and sensitivity of dialysis staff (50% (48% to 52%)); and ease of reaching dialysis staff by telephone (48% (46% to 50%)). The aspects of care least frequently ranked as excellent were information provided when choosing a dialysis modality (23% (21% to 25%)), ease of seeing a social worker (28% (24% to 32%)), information provided about dialysis (34% (32% to 36%)), accuracy of information from nephrologist (eg, about prognosis or likelihood of a kidney transplant; 37% (35% to 39%)) and accuracy of nephrologists’ instructions (39% (36% to 41%)).ConclusionsHaemodialysis patients are least satisfied with the complex aspects of care. Patients’ expectations for accurate information, prognosis, the likelihood of kidney transplantation and their options when choosing dialysis treatment need to be considered when planning healthcare research and practices.
Keeping children safe at home: protocol for a case–control study of modifiable risk factors for scalds
Authors: Wynn P , Stewart J , Kumar A , Clacy R , Coffey F , Cooper N , Coupland C , Deave T , Hayes M , McColl E , Reading R , Sutton A , Watson M , Kendrick D 
Published: May 2014

BackgroundScalds are one of the most common forms of thermal injury in young children worldwide. Childhood scald injuries, which mostly occur in the home, result in substantial health service use and considerable morbidity and mortality. There is little research on effective interventions to prevent scald injuries in young children.ObjectivesTo determine the relationship between a range of modifiable risk factors for medically attended scalds in children under the age of 5 years.DesignA multicentre case-control study in UK hospitals and minor injury units with parallel home observation to validate parental reported exposures. Cases will be 0–4 years old with a medically attended scald injury which occurred in their home or garden, matched on gender and age with community controls. An additional control group will comprise unmatched hospital controls drawn from children aged 0–4 years attending the same hospitals and minor injury units for other types of injury. Conditional logistic regression will be used for the analysis of cases and matched controls, and unconditional logistic regression for the analysis of cases and unmatched controls to estimate ORs and 95% CI, adjusted and unadjusted for confounding variables.Main exposure measuresUse of safety equipment and safety practices for scald prevention and scald hazards.DiscussionThis large case-control study will investigate modifiable risk factors for scalds injuries, adjust for potential confounders and validate measures of exposure. Its findings will enhance the evidence base for prevention of scalds injuries in young children.
Randomized Rounding in the Presence of a Cardinality Constraint
Authors: Doerr Benjamin , Wahlström Magnus 
Published: May 2014

We consider the problem of generating randomized roundings that satisfy a single cardinality constraint and admit Chernoff-type large deviation bounds for weighted sums of the variables. That this can be done efficiently was proven by Srinivasan [2001], a different approach was later given by the first author [Doerr 2006]. In this work, we (a) present an improved version of the bitwise derandomization given by Doerr, (b) give the first derandomization of Srinivasan's tree-based randomized approach and prove its correctness, and (c) experimentally compare the resulting algorithms.
Our experiments show that adding a single cardinality constraint typically reduces the rounding errors and only moderately increases the running times. In general, our derandomization of the tree-based approach is superior to the derandomized bitwise one, while the two randomized versions produce very similar rounding errors. When implementing the derandomized tree-based approach, however, the choice of the tree is important.
Continued Rapid Increase in Thyroid Cancer Incidence in California: Trends by Patient, Tumor, and Neighborhood Characteristics
Authors: Horn-Ross Pamela L. , Lichtensztajn Daphne Y. , Clarke Christina A. , Dosiou Chrysoula , Oakley-Girvan Ingrid , Reynolds Peggy , Gomez Scarlett Lin , Nelson David O. 
Published: May 2014

AbstractBackground: Thyroid cancer incidence is increasing worldwide. Incorporating 22 years of incidence data through 2009, we extend examination of these trends among a wide array of subgroups defined by patient (age, sex, race/ethnicity, and nativity), tumor (tumor size and stage), and neighborhood (socioeconomic status and residence in ethnic enclaves) characteristics, to identify possible reasons for this increase.Methods: Thyroid cancer incidence data on 10,940 men and 35,147 women were obtained from the California Cancer Registry for 1988–2009. Population data were obtained from the 1990 and 2000 U.S. Census. Incidence rates and 95% confidence intervals (CI) were calculated and incidence trends were evaluated using Joinpoint regression to evaluate the timing and magnitude of change [annual percentage change (APC) and rate ratios].Results: The incidence of papillary thyroid cancer continues to increase in both men (APC, 5.4; 95% CI, 4.5–6.3 for 1998–2009) and women (APC, 3.8; 95% CI, 3.4–4.2 for 1998–2001 and APC, 6.3; 95% CI, 5.7–6.9 for 2001–2009). Increasing incidence was observed in all subgroups examined.Conclusions: Although some variation in the magnitude or temporality of the increase in thyroid cancer incidence exists across subgroups, the patterns (i) suggest that changes in diagnostic technology alone do not account for the observed trends and (ii) point to the importance of modifiable behavioral, lifestyle, or environmental factors in understanding this epidemic.Impact: Given the dramatic and continued increase in thyroid cancer incidence rates, studies addressing the causes of these trends are critical. Cancer Epidemiol Biomarkers Prev; 23(6); 1067–79. ©2014 AACR.
Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice
Authors: Moiola Cristian P. , De Luca Paola , Zalazar Florencia , Cotignola Javier , Rodríguez-Seguí Santiago A. , Gardner Kevin , Meiss Roberto , Vallecorsa Pablo , Pignataro Omar , Mazza Osvaldo , Vazquez Elba S. , De Siervi Adriana 
Published: May 2014

Abstract
Purpose: Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, and increased mortality. C-terminal–binding protein 1 (CtBP1) is a transcription repressor of tumor suppressor genes and is activated by NADH binding. High calorie intake decreases intracellular NAD+/NADH ratio. The aim of this work was to assess the effect of high-fat diet (HFD) and CtBP1 expression modulation over prostate xenograft growth.
Experimental Design: We developed a metabolic syndrome-like disease in vivo model by feeding male nude mice with HFD during 16 weeks. Control diet (CD)–fed animals were maintained at the same conditions. Mice were inoculated with PC3 cells stable transfected with shCtBP1 or control plasmids. Genome-wide expression profiles and Gene Set Enrichment Analysis (GSEA) were performed from PC3.shCtBP1 versus PC3.pGIPZ HFD-fed mice tumors.
Results: No significant differences were observed in tumor growth on CD-fed mice; however, we found that only 60% of HFD-fed mice inoculated with CtBP1-depleted cells developed a tumor. Moreover these tumors were significantly smaller than those generated by PC3.pGIPZ control xenografts. We found 823 genes differentially expressed in shCtBP1 tumors from HFD-fed mice. GSEA from expression dataset showed that most of these genes correspond to cell adhesion, metabolic process, and cell cycle.
Conclusions: Metabolic syndrome–like diseases and CtBP1 expression cooperate to induce prostate tumor growth. Hence, targeting of CtBP1 expression might be considered for prostate cancer management and therapy in the subset of patients with metabolic syndromes. Clin Cancer Res; 20(15); 4086–95. ©2014 AACR.
Myocardial Recovery From Ischemia–Reperfusion Is Compromised in the Absence of Tissue Inhibitor of Metalloproteinase 4
Authors: Takawale Abhijit , Fan Dong , Basu Ratnadeep , Shen Mengcheng , Parajuli Nirmal , Wang Wang , Wang Xiuhua , Oudit Gavin Y. , Kassiri Zamaneh 
Published: May 2014

Background—
Myocardial reperfusion after ischemia (I/R), although an effective approach in rescuing the ischemic myocardium, can itself trigger several adverse effects including aberrant remodeling of the myocardium and its extracellular matrix. Tissue inhibitor of metalloproteinases (TIMPs) protect the extracellular matrix against excess degradation by matrix metalloproteinases (MMPs). TIMP4 levels are reduced in myocardial infarction; however, its causal role in progression of post-I/R injury has not been explored.

Methods and Results—

In vivo I/R (20-minute ischemia, 1-week reperfusion) resulted in more severe systolic and diastolic dysfunction in TIMP4
−/−
mice with enhanced inflammation, oxidative stress (1 day post-I/R), hypertrophy, and interstitial fibrosis (1 week). After an initial increase in TIMP4 (1 day post-I/R), TIMP4 mRNA and protein decreased in the ischemic myocardium from wild-type mice by 1 week post-I/R and in tissue samples from patients with myocardial infarction, which correlated with enhanced activity of membrane-bound MMP, membrane-type 1 MMP. By 4 weeks post-I/R, wild-type mice showed no cardiac dysfunction, elevated TIMP4 levels (to baseline), and normalized membrane-type 1 MMP activity. TIMP4-deficient mice, however, showed exacerbated diastolic dysfunction, sustained elevation of membrane-type 1 MMP activity, and worsened myocardial hypertrophy and fibrosis. Ex vivo I/R (20- or 30-minute ischemia, 45-minute reperfusion) resulted in comparable cardiac dysfunction in wild-type and TIMP4
−/−
mice.

Conclusions—
TIMP4 is essential for recovery from myocardial I/R in vivo, primarily because of its membrane-type 1 MMP inhibitory function. TIMP4 deficiency does not increase susceptibility to ex vivo I/R injury. Replenishment of myocardial TIMP4 could serve as an effective therapy in post-I/R recovery for patients with reduced TIMP4.
Contemporary Trends of Hospitalization for Atrial Fibrillation in the United States, 2000 Through 2010
Authors: Patel Nileshkumar J. , Deshmukh Abhishek , Pant Sadip , Singh Vikas , Patel Nilay , Arora Shilpkumar , Shah Neeraj , Chothani Ankit , Savani Ghanshyambhai T. , Mehta Kathan , Parikh Valay , Rathod Ankit , Badheka Apurva O. , Lafferty James , Kowalski Marcin , Mehta Jawahar L. , Mitrani Raul D. , Viles-Gonzalez Juan F. , Paydak Hakan 
Published: May 2014

Background—
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The associated morbidity and mortality make AF a major public health burden. Hospitalizations account for the majority of the economic cost burden associated with AF. The main objective of this study is to examine the trends of AF-related hospitalizations in the United States and to compare patient characteristics, outcomes, and comorbid diagnoses.

Methods and Results—

With the use of the Nationwide Inpatient Sample from 2000 through 2010, we identified AF-related hospitalizations using
International Classification of Diseases, 9th Revision, Clinical Modification
code 427.31 as the principal discharge diagnosis. Overall AF hospitalizations increased by 23% from 2000 to 2010, particularly in patients ≥65 years of age. The most frequent coexisting conditions were hypertension (60.0%), diabetes mellitus (21.5%), and chronic pulmonary disease (20.0%). Overall in-hospital mortality was 1%. The mortality rate was highest in the group of patients ≥80 years of age (1.9%) and in the group of patients with concomitant heart failure (8.2%). In-hospital mortality rate decreased significantly from 1.2% in 2000 to 0.9% in 2010 (29.2% decrease;
P
<0.001). Although there was no significant change in mean length of stay, mean cost of AF hospitalization increased significantly from $6410 in 2001 to $8439 in 2010 (24.0% increase;
P
<0.001).

Conclusions—
Hospitalization rates for AF have increased exponentially among US adults from 2000 to 2010. The proportion of comorbid chronic diseases has also increased significantly. The last decade has witnessed an overall decline in hospital mortality; however, the hospitalization cost has significantly increased.
The Onion and the Mandrake: Plants in Yezidi Folk Beliefs
Authors: Arakelova Victoria 
Published: May 2014

Abstract
The non-dogmatic character of the Yezidi religion presupposes the presence of a heavy layer of so-called “primitive” religious elements, including plant worship. This paper focuses on plants having obvious sacred connotations in Yezidi beliefs, both on the level of the cult and marginal folk beliefs. There is no explicit tree cult in the Yezidism, or dendrolatry, despite the existence of a cultic complex connected with the so-called Dārā mirāzā or “The trees of Desire”. Still, there are representatives of the flora world that bear obvious cultic attribution, the most important of which are the onion and the mandrake. The mandrake has mystical fame and reverence not only among the Yezidis, but also among many other peoples of the region. This panacea for all diseases, widely used in folk medicine, is also considered an important element of the materia magica, primarily due to its aphrodisiac qualities. This paper will provide a comparative analysis of plant worship among the Yezidis and several other traditions of the Caucaso-Iranian region.
Australia’s deep-water octocoral fauna: historical account and checklist, distributions and regional affinities of recent collections
Authors: ALDERSLADE PHILIP , ALTHAUS FRANZISKA , MCENNULTY FELICITY , GOWLETT-HOLMES KAREN , WILLIAMS ALAN 
Published: May 2014

The number of deep-water (>80 m) octocoral species recorded from Australian waters has more than tripled from 135 to 457 following six surveys undertaken between 1997 and 2008 on the deep continental margin of south-eastern, western and north-western Australia and the Tasman Sea. This rapid increase in knowledge follows a slow accumulation of records since the earliest collections were made by vessels such as the Géographe and the Naturaliste in the early years of the 19th century. Consistent identification and alpha-labelling of the octocoral fauna between surveys has permitted a multi-region description and comparison. We detail the identities, distributions and regional affinities of 457 octocoral species in 131 genera and 28 families from the orders Alcyonacea and Pennatulacea, including 69 new species, 17 new genera and 43 first records for Australia. Five of the more common genera were widely distributed (present at 35 and 66 sampling stations spanning all of the 4 survey regions), but two were restricted to south-eastern Australia—Pleurogorgia Versluys, 1902 and Tokoprymno Bayer, 1996—and were only sampled from depths below 700 m. The great majority of species (81%) and nearly half of all genera (47%) were only sampled once or twice. The highest average number of species per sampling station (3.2) was reported from the outer shelf. The proportion of new species was highest (>22%) on the upper and lower slope bathomes, intermediate (13–15%) on the mid-slope bathome and lowest (8%) on the outer shelf bathome. Species overlap between bathomes was low, but all families were shared across bathomes. Most described species (55 of 69) have an Indo-West Pacific affinity, 20 have an Indian Ocean affinity, while three were previously recorded from the Atlantic Ocean only; 20 appear to be Australian endemics. Octocorals can now be added to an emerging set of taxon-specific data sets—including fishes, ophiuroids and galatheids—that permit regional-scale analysis of biodiversity distributions to support Australia’s efforts in marine conservation management. However, because so much of the world octocoral literature is inadequate for accurate identifications to species level, there is a pressing need for taxonomic revisions using modern morphological and molecular techniques to fine-tune the current use of octocorals as indicators of vulnerable marine ecosystems in many national and high seas conservation initiatives.
Long-Term Variations of the Kuroshio Extension Path in Winter: Meridional Movement and Path State Change
Authors: Seo Yasuharu , Sugimoto Shusaku , Hanawa Kimio 
Published: May 2014

Abstract
As an indicator of the Kuroshio Extension (KE) path, the KE northern boundary (KENB) was detected based on the position of the strong winter sea surface temperature (SST) gradient between 142° and 155°E, using high spatial resolution satellite-derived SST for the 30 winters (January to March) from 1982 to 2011. The KE path showed meridional movement with a period of 10–15 yr and an amplitude of about 2° latitude. The changes in latitudinal position of the KE path were initiated by a north–south shift of the Aleutian low (AL). Negative wind stress curl anomalies around 35°N in the eastern North Pacific associated with a northward shift of the AL induced a deepening of the main thermocline depth, and then this deepening signal propagated westward, reaching the KE region after about 3 yr, where it caused the KE path to move northward. The path state of the KE (straight path/convoluted path) modulated on a time scale of 8–12 yr, but this was not significantly correlated with the meridional movement of the KE path. The anticyclonic eddies containing warm-salty water that detached northward from the convoluted KE exerted a strong influence on oceanic conditions in the Kuroshio–Oyashio Confluence (KOC) region. The changes in path state of the KE were related to the path of the Kuroshio south of Japan over the long term; a convoluted (straight) KE path was associated with the Kuroshio taking the offshore nonlarge (nearshore nonlarge or typical large) meander path.
A Multiple-Vortex Tornado in Southeastern Brazil
Authors: de Lima Nascimento Ernani , Held Gerhard , Gomes Ana Maria 
Published: May 2014

AbstractDuring the late afternoon hours of 24 May 2005 a severe weather outbreak occurred in the state of São Paulo, southeastern Brazil. Severe thunderstorms were observed ahead of a surface cold front, including a (Southern Hemisphere) cyclonic left-moving supercell that produced a multiple-vortex tornado in the outskirts of the town of Indaiatuba, Brazil (23.1°S, 47.2°W). A documentation of the multivortex structure of the tornado and of the cloud-base features is performed using still images from a video that recorded the event. Characteristics of the tornadic thunderstorm and the synoptic-scale environment in which it developed are examined using Doppler radar data, geostationary satellite imagery, surface and upper-air observations, and data from the National Centers for Environmental Prediction’s Climate Forecast System Reanalysis. The cloud base of the thunderstorm displayed morphological features associated with midlatitude tornadic supercells, including a low-level mesocyclone and a “clear slot”; however, the rear-flank downdraft did not obscure the view of the tornado from the western flank of the storm. The tornadic storm developed in a moist prefrontal environment with a low-level jet. Limited mesoscale observations hampered the quantitative analysis of the local thermodynamic forcing, but the available data suggest that the supercell developed under moderate conditional instability. Strong speed and directional vertical wind shear were observed, while the local boundary layer displayed very high relative humidity and low surface-based lifting condensation level.
The Role of Convective Outflow in the Waldo Canyon Fire
Authors: Johnson Richard H. , Schumacher Russ S. , Ruppert James H. , Lindsey Daniel T. , Ruthford Julia E. , Kriederman Lisa 
Published: May 2014

AbstractThe meteorological conditions associated with the rapid intensification and spread of the catastrophic Waldo Canyon fire on 26 June 2012 are studied. The fire caused two fatalities, destroyed 347 homes in Colorado Springs, and resulted in insurance losses of nearly $0.5 billion (U.S. dollars), making it the most economically destructive fire in Colorado’s history. While the fire was first discovered on 23 June, the paper focuses on 26 June, when it grew explosively and rapidly advanced eastward into a heavily populated area on the west side of Colorado Springs. Near-record hot and dry conditions prevailed over the Intermountain West prior to the fire, along with a persistent upper-level ridge. On 26 June, a narrow tongue of moist air aloft originating over the Southwest shifted from Utah into Colorado. Dry conditions at low levels and moisture aloft set the stage for strong microburst-producing thunderstorms to develop over Colorado. Convective cells first formed at midday over the San Juan Mountains, later consolidating into a thunderstorm complex that produced an organized convective outflow with strong, gusty winds at the surface. The leading gust front associated with the outflow moved past the Waldo Canyon fire at the hottest time of the day with recorded wind gusts up to 26 m s−1. The rapid eastward advance of the fire, as well as an onset of pyrocumulonimbus and lightning activity, was timed with the passage of the gust front. A numerical simulation, initiated one day earlier, produced mesoscale features closely resembling those observed, including the gust front passage at the fire and the vertical structure of the convective outflow.