bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guideline-Directed Low-Density Lipoprotein Management in High-Risk Patients With Ischemic Stroke
Authors: Saposnik Gustavo , Fonarow Gregg C. , Pan Wenquin , Liang Li , Hernandez Adrian F. , Schwamm Lee H. , Smith Eric E. 
Published: October 2014

Background and Purpose—
Limited information is available on stroke prevention in high-risk patients with preexisting cardiovascular disease. Our aim was to use admission low-density lipoprotein (LDL) values to evaluate differences in the attainment of National Cholesterol Education Program-Adult Treatment Panel III guidelines goals at the time of the index event in high-risk patients with stroke and preexisting cardio- or cerebrovascular disease.

Methods—
Observational study, using data from the Get-With-The-Guidelines-Stroke Registry including 913 436 patients with an acute ischemic stroke or transient ischemic attack from April 2003 to September 2012. Participants were classified as high risk if they had history of transient ischemic attack (TIA), stroke (cardiovascular disease), and coronary artery disease (CAD).

Results—
Of the 913 436 patients admitted with an acute stroke or TIA, 194 557 (21.3%) had previous stroke/TIA, 148 833 (16.3%) had previous CAD, and 88 605 (9.7%) had concomitant CAD and cardiovascular disease. Overall, only 68% of patients with stroke were at their preadmission National Cholesterol Education Program III guideline-recommended LDL target; 51.3% had LDL <100 mg/dL; and only 19.8% had LDL<70 mg/dL. Among those presenting with a recurrent stroke, >45% had LDL>100 mg/dL. When compared with patients with CAD, patients with previous TIA/stroke were less likely to have LDL<100 or <70 mg/dL. In multivariable analysis, older age, men, white race, lack of major vascular risk factors, previous use of cholesterol-lowering therapy, and care provided in larger hospitals were associated with meeting LDL targets on admission testing.

Conclusions—
Management of dyslipidemia in high-risk patients with preexistent CAD or stroke continues to be suboptimal. Only 1 in 5 patients with prior TIA/stroke had LDL levels <70 mg/dL.
Characterizing AMV Height-Assignment Error by Comparing Best-Fit Pressure Statistics from the Met Office and ECMWF Data Assimilation Systems
Authors: Salonen Kirsti , Cotton James , Bormann Niels , Forsythe Mary 
Published: October 2014

AbstractTo ensure realistic use of atmospheric motion vector (AMV) observations in data assimilation, the error characteristics of the observation type need to be known and carefully taken into account. Assigning a height to the tracked feature is one of the most significant error sources for AMV observations. In this article, the characteristics of the AMV height-assignment error are studied by comparing model best-fit pressure statistics between the Met Office and ECMWF data assimilation systems. The aim is to provide detailed uncertainty estimates for the assigned pressure and to demonstrate that the best-fit pressure enables reliable estimation of the uncertainties in the AMV height assignment. Typical values for the standard deviation of the difference between the assigned pressure and the best-fit pressure are 50–80 hPa at high levels, 115–165 hPa at midlevels, and 60–125 hPa at low levels, depending on satellite, channel, and height-assignment method. Observed minus best-fit pressure biases are mostly within the range of ±50 hPa. The results are very similar for the Met Office and ECMWF systems, suggesting that the pressure differences are not strongly dependent on the data assimilation system. Furthermore, the findings are in good agreement with the expected characteristics of the height-assignment methods and quality of the observations. Thus, best-fit pressure statistics give reliable information about the uncertainties in the AMV height assignment.
The Tropical Precipitation Response to Andes Topography and Ocean Heat Fluxes in an Aquaplanet Model
Authors: Maroon Elizabeth A. , Frierson Dargan M. W. , Battisti David S. 
Published: October 2014

Abstract
This aquaplanet modeling study using the Geophysical Fluid Dynamics Laboratory Atmospheric Model, version 2.1 (GFDL AM2.1), examines how ocean energy transport and topography influence the location of tropical precipitation. Adding realistic Andes topography regionally displaces tropical rainfall from the equator into the Northern Hemisphere, even when the wind–evaporation feedback is disabled. The relative importance of the Andes compared to the asymmetric hemispheric heating of the atmosphere by ocean transport is examined by including idealized and realistic zonally averaged surface heat fluxes (also known as q fluxes) in the slab ocean. A hemispherically asymmetric q flux displaces the tropical rainfall toward the hemisphere receiving the greatest heating by the ocean. The zonal-mean displacement of rainfall is greater in simulations with a realistic q flux than with a realistic Andes topography. Simulations that add both a q flux and topography displace rainfall farther to the north in the region 120° to the west of the Andes than in simulations that only have a q flux. Cloud and clear-sky radiative feedbacks in the tropics and subtropics of this model both act to amplify the energy flux and the precipitation response to a given hemispheric asymmetry in oceanic forcing.
Beyond Weather Time-Scale Prediction for Hurricane Sandy and Super Typhoon Haiyan in a Global Climate Model
Authors: Xiang Baoqiang , Lin Shian-Jiann , Zhao Ming , Zhang Shaoqing , Vecchi Gabriel , Li Tim , Jiang Xianan , Harris Lucas , Chen Jan-Huey 
Published: October 2014

Abstract
While tropical cyclone (TC) prediction, in particular TC genesis, remains very challenging, accurate prediction of TCs is critical for timely preparedness and mitigation. Using a new version of the Geophysical Fluid Dynamics Laboratory (GFDL) coupled model, the authors studied the predictability of two destructive landfall TCs: Hurricane Sandy in 2012 and Super Typhoon Haiyan in 2013. Results demonstrate that the geneses of these two TCs are highly predictable with the maximum prediction lead time reaching 11 days. The “beyond weather time scale” predictability of tropical cyclogenesis is primarily attributed to the model’s skillful prediction of the intraseasonal Madden–Julian oscillation (MJO) and the westward propagation of easterly waves. Meanwhile, the landfall location and time can be predicted one week ahead for Sandy’s U.S landfall, and two weeks ahead for Haiyan’s landing in the Philippines. The success in predicting Sandy and Haiyan, together with low false alarms, indicates the potential of using the GFDL coupled model for extended-range predictions of TCs.
Ultrasound-assisted lysis using recombinant tissue plasminogen activator and the EKOS EkoSonic endovascular system for treating right atrial thrombus and massive pulmonary embolism: A case study
Authors: Shammas NW , Padaria R , Ahuja G 
Published: October 2014

Objective Right atrial thrombus in the setting of a large pulmonary embolus is rare and is associated with serious adverse events. This case report presents the role played by EKOS EkoSonic ultrasound system in successfully treating right atrial thrombus and massive pulmonary embolism. Case report A 69-year-old female presented with a massive pulmonary embolus and a large mobile right atrial thrombus. She was treated with catheter-directed lysis using the EKOS EkoSonic ultrasound system and tissue plasminogen activator, with complete resolution of her right atrial thrombus and a marked improvement in her pulmonary embolus and hemodynamics. Conclusion This case report provides a new and an effective option to treat right atrial thrombus associated with a large pulmonary embolus leading to a good outcome.
Progressive maturation toward hematopoietic stem cells in the mouse embryo aorta
Authors: Boisset Jean-Charles , Clapes Thomas , Klaus Anna , Papazian Natalie , Onderwater Jos , Mommaas-Kienhuis Mieke , Cupedo Tom , Robin Catherine 
Published: October 2014

Key PointsIntraaortic clusters contain pre-HSCs progressively maturing toward an HSC fate.
Initial stem cell adhesion on porous silicon surface: molecular architecture of actin cytoskeleton and filopodial growth
Authors: Collart-Dutilleul Pierre-Yves , Panayotov Ivan , Secret Emilie , Cunin Frédérique , Gergely Csilla , Cuisinier Frédéric , Martin Marta 
Published: October 2014

Abstract
The way cells explore their surrounding extracellular matrix (ECM) during development and migration is mediated by lamellipodia at their leading edge, acting as an actual motor pulling the cell forward. Lamellipodia are the primary area within the cell of actin microfilaments (filopodia) formation. In this work, we report on the use of porous silicon (pSi) scaffolds to mimic the ECM of mesenchymal stem cells from the dental pulp (DPSC) and breast cancer (MCF-7) cells. Our atomic force microscopy (AFM), fluorescence microscopy, and scanning electron microscopy (SEM) results show that pSi promoted the appearance of lateral filopodia protruding from the DPSC cell body and not only in the lamellipodia area. The formation of elongated lateral actin filaments suggests that pores provided the necessary anchorage points for protrusion growth. Although MCF-7 cells displayed a lower presence of organized actin network on both pSi and nonporous silicon, pSi stimulated the formation of extended cell protrusions.
Split hierarchical variational inequality problems and related problems
Authors: Ansari Qamrul Hasan , Nimana Nimit , Petrot Narin 
Published: October 2014

Abstract
The main objective of this paper is to introduce a split hierarchical variational inequality problem. Several related problems are also considered. We propose an iterative method for finding a solution of our problem. The weak convergence of the sequence generated by the proposed method is studied.

MSC:47H09, 47H10, 47J25, 49J40, 65K10.
A non-convex gradient fidelity-based variational model for image contrast enhancement
Authors: Liu Qiegen , Liu Jianbo , Xiong Biao , Liang Dong 
Published: October 2014

Abstract
We propose a novel image contrast enhancement method via non-convex gradient fidelity-based (NGF) variational model which consists of the data fidelity term and the NGF regularization. The NGF prior assumes that the gradient of the desired image is close to the multiplication of the gradient of the original image by a scale factor, which is adaptively proportional to the difference of their gradients. The presented variational model can be viewed as a data-driven alpha-rooting method in the gradient domain. An augmented Lagrangian method is proposed to address this optimization issue by first transforming the unconstrained problem to an equivalent constrained problem and then applying an alternating direction method to iteratively solve the subproblems. Experimental results on a number of images consistently demonstrate that the proposed algorithm can efficiently obtain visual pleasure results and achieve favorable performance than the current state-of-the-art methods.
A method for preparation and cleaning of uniformly sized arsenopyrite particles
Authors: Parthasarathy Hariprasad , Baltrus John P , Dzombak David A , Karamalidis Athanasios K 
Published: October 2014

Abstract

Background
The oxidative dissolution of sulfide minerals, such as arsenopyrite (FeAsS), is of critical importance in many geochemical systems. A comprehensive understanding of their dissolution rates entails careful preparation of the mineral surface. Measurements of dissolution rates of arsenic from arsenopyrite are dependent on the size and degree of oxidation of its particles, among other factors. In this work, a method was developed for preparation and cleaning of arsenopyrite particles with size range of 15-250 μm. Four different cleaning methods were evaluated for effectiveness based on the removal of oxidized species of iron (Fe), arsenic (As) and sulfur (S) from the surface. The percentage oxidation of the surface was determined using X-ray photoelectron spectroscopy (XPS), and surface stoichiometry was measured using scanning electron microscopy - energy dispersive X-ray spectroscopy (SEM-EDS).

Results
Results indicate that sonicating the arsenopyrite particles and then cleaning them with 12N HCl followed by 50% ethanol, and drying in nitrogen was the most effective method. This method was successful in greatly reducing the oxide species of Fe while completely removing oxides of As and S from the arsenopyrite surface.

Conclusions
Although sonication and acid cleaning have been widely used for mineral preparation, the method described in this study can significantly reduce grain size heterogeneity as well as surface oxidation, which enables greater control in surface and dissolution experiments.
Changes in talocrural and subtalar joint kinematics of barefoot versus shod forefoot landing
Authors: Fukano Mako , Fukubayashi Toru 
Published: October 2014

AbstractBackgroundSynergetic talocrural and subtalar joint movements allow adaptation to different footwear and/or surface conditions. Therefore, knowledge of kinematic differences between barefoot and shod conditions is valuable for the study of adaptations to footwear conditions. The objective of this study was to assess the kinematic differences in the talocrural and subtalar joints during barefoot and shod landing.MethodsSeven healthy participants (4 males and 3 females) participated in a landing trial under barefoot and shod conditions. Fluoroscopic images and forceplate data were collected simultaneously to calculate the talocrural and subtalar joint kinematics and the vertical ground reaction force.ResultsUpon toe contact, the plantarflexion angle of the talocrural joint during the barefoot condition was significantly larger than that during the shod condition (barefoot, 20.5 ± 7.1°, shod, 17.9 ± 8.3°, p =0.03). From toe contact to heel contact, the angular changes at the talocrural and subtalar joint were not significantly different between the barefoot and shod conditions; however, the changes in the subtalar eversion angles in the barefoot condition, from heel contact to 150 ms after toe contact, were significantly larger than those in the shod condition.ConclusionsThese results suggest that footwear was able to reduce the eversion angle of the subtalar joint after heel contact during landing; the effect of wearing footwear was quite limited. Therefore, induced rearfoot kinematic alterations to prevent or manage injuries by neutral‐type footwear are likely to be impractical.
Prognostic Value of Microscopic Lymph Node Involvement in Patients With Papillary Thyroid Cancer
Authors: Bardet Stéphane , Ciappuccini Renaud , Quak Elske , Rame Jean-Pierre , Blanchard David , de Raucourt Dominique , Babin Emmanuel , Michels Jean-Jacques , Vaur Dominique , Heutte Natacha 
Published: October 2014

Abstract

Context:
The impact of microscopic nodal involvement on the risk of persistent/recurrent disease (PRD) remains controversial in patients with papillary thyroid carcinoma (PTC).

Objective:
The goal of the study was to assess the risk of PRD and the 4-year outcome in PTC patients according to their initial nodal status [pNx, pN0, pN1 microscopic (cN0/pN1) or pN1 macroscopic (cN1/pN1)].

Design:
We conducted a retrospective cohort study.

Patients:
The study included 305 consecutive PTC patients referred for radioiodine ablation from 2006 to 2011.

Main Outcome Measure:
We evaluated the risk of structural PRD and the disease status at the last follow-up. At ablation, persistent disease was consistently assessed by using post-radioiodine ablation scintigraphy combining total body scan and neck and thorax single-photon computed tomography-computed tomography (SPECT-CT) acquisition.

Results:
Of 305 patients, 128 (42%) were pNx, 84 (28%) pN0, 44 (14%) pN1 microscopic, and 49 (16%) pN1 macroscopic. The 4-year cumulative risk of PRD was higher in pN1 macroscopic than in pN1 microscopic patients (49% vs 24%, P = .03), and higher in pN1 microscopic than in pN0 (12%, P = .01) or pNx patients (6%, P &lt; .001). On multivariate analysis, tumor size of 20 mm or greater [relative risk (RR) 3.4; P = .0001], extrathyroid extension (RR 2.6; P &lt; .003), pN1 macroscopic (RR 4.5; P &lt; .0001), and pN1 microscopic (RR 2.5; P &lt; .02) were independent risk factors for PRD. At the last visit, the proportion of patients with no evidence of disease decreased from pNx (98%), pN0 (93%), and pN1 microscopic (89%) to pN1 macroscopic patients (70%) (P &lt; .0001, Cochran-Armitage trend test). Extrathyroid extension (odds ratio 9.7; P &lt; .0001) and N1 macroscopic (OR 4.9; P &lt; .001) independently predicted persistent disease at the last visit, but N1 microscopic did not.

Conclusions:
Patients with microscopic lymph node involvement present an intermediate outcome between that observed in pN0-pNx patients and pN1 macroscopic patients. These data may justify modifications to the risk recurrence staging systems.
Thermoresponsive Reversible Phase-transition of Alginate-based Semi-IPN Gel through Self-assembly of Interpenetrated Elastin-like Polypeptide
Authors: Matsukuma Daisuke , Otsuka Hidenori 
Published: October 2014

Abstract
We describe, for the first time, a simple and one-pot fabrication of biocompatible hydrogels functioning as an elastin-like polypeptide (ELP) matrix in terms of thermoresponsibility and structure-proved bioavailability, without complicated pretreatment and synthesis. For this purpose, composite hydrogels were formed with a semi-IPN structure wherein untreated ELPs interpenetrated the alginate–Ca2+ hydrogel as the host three-dimensional network. These biocompatible and stimuli-responsive materials are highly useful as a novel injectable matrix to induce tissue differentiation after cellular encapsulation.
Surface Functionalization of Protein Crystals with Carbohydrate Using Site-selective Bioconjugation
Authors: Abe Satoshi , Tokura Yu , Pal Rita , Komura Naoko , Imamura Akihiro , Matsumoto Kaori , Ijiri Hiroshi , Sanghamitra Nusrat J M , Tabe Hiroyasu , Ando Hiromune , Kiso Makoto , Mori Hajime , Kitagawa Susumu , Ueno Takafumi 
Published: October 2014

Abstract
A crystalline solid protein assembly was functionalized with Lewis X (LeX) carbohydrates via site-selective bioconjugation of cysteine residues. An antibody can bind to the surface of modified crystals through antigen–antibody interactions. The surface modification of protein crystals would provide attractive materials for applications involving extracellular matrices, biosolid catalysis, and drug delivery systems.
Examination of the Main Educational Program of the Educational Organization as an Instrument of Advancing Management of the Innovative Project on Introduction of Federal State Educational Standards of General Education
Authors: �����������  , Pokosovskaya Olga 
Published: October 2014

Defining introduction of the Federal State Educational Standards (FSES) of General Education as the innovative project directed on achievement of qualitatively
new level of development of education system, the author considers examination of the main educational program (MEP) of the educational
organization of the maingeneral education levelas the effective instrument of ensuring dynamic management of educational system development.
The article describes technique and results of carrying out examination of MEP, as well as technique of organization of self-audit of an educational
organization readiness to transition to FSES of the main general education which is previous to MEP examination procedure and an integral part of
the problem-oriented analysis of aneducational system condition. Application of the offered tools on the basis of analytical data on current state of
educational system allows building the forecast of its development, revealingreference points and defining the main vectors of administrative activity.
G-Protein Receptor Kinase 4 Polymorphism and Response to Antihypertensive Therapy
Authors: Muskalla Anne M , Suter Paolo M , Saur Matthias , Nowak Albina , Hersberger Martin , Krayenbuehl Pierre-Alexandre 
Published: October 2014

Abstract

BACKGROUND
G-protein receptor kinase 4 polymorphism influences blood pressure regulation via modulation of dopamine receptor D1 in renal proximal tubular cells. We investigated the role of G-protein receptor kinase 4 polymorphism in the response to hypertensive therapy in patients with essential hypertension.

METHODS
In a prospective study, we assessed the G-protein receptor kinase 4 polymorphisms R65L, A142V, and A486V in 100 hypertensive patients. We analyzed the association of the 3 gene variants on blood pressure control and response to antihypertensive therapy with single-locus analysis, haplotype analysis, and regression analysis.

RESULTS
Hypertensive individuals with a homozygous double variant of 65L and 142V needed significantly more antihypertensive treatment (number of antihypertensives 2.59 vs 1.95, P = 0.043) and especially diuretic therapy (0.82 vs 0.49, P = 0.029) to reach the same mean arterial blood pressure than did homozygous carriers of only 1 variant or heterozygous/wild-type carriers of R65L, A142V, and A486V alleles.

CONCLUSIONS
G-protein receptor kinase 4 polymorphism is associated with antihypertensive treatment response in patients with essential hypertension. Determination of G-protein receptor kinase 4 polymorphism may improve individual antihypertensive blood pressure control in patients with essential hypertension.
Book Reviews
Authors: Ajana Btihaj , Cooley Alison , Crone Bridget , Lau Charlene K. , North Meredith , Roberts Jack , Sanader Daniella E. , Waters M.J. , Anderson Peter , Reeve Charles 
Published: October 2014

The Curatorial: A Philosophy of Curating, Jean-Paul Martinon (Ed.) London: Bloomsbury Academic (2013), 280 pp., Paperback, ISBN: 978-1-47252-560-4, £65.00
Scandalous: A Reader on Art and Ethics, Nina Möntmann (ED.) Berlin: Sternberg Press (2013), 178 pp., Paperback, ISBN:
978-1-93410-587-0, €19.00
Institutional Attitudes: Instituting Art in a Flat World, Pascal Gielen (Ed.) Amsterdam: Valiz (2013), Antennae Series No. 8, 288 pp., Paperback, ISBN: 978-9-07808-868-4, €19.50
Art & Textiles: Fabric as Material and Concept in Modern Art from
Klimt to the Present, Marcus Brüderlin (Ed.) Ostfildern: Hatje Cantz Verlag (2013), 392 pp., Hardcover, ISBN: 978-3-77573-627-5 (English), ISBN: 978-3-77573-626-8 (German), €49.80
The Global Contemporary and the Rise of New Art Worlds, Hans Belting, Andrea Buddensieg and Peter
Weibel (eds) Cambridge, MA: MIT Press with ZKM/Center for Art and Media Karlsruhe (2013), 464 pp., Paperback, ISBN: 978-0-26251-834-5, US$50.00
Art Production Beyond the Art Market?, Karen van den Berg and Ursula Pasero (eds) Berlin: Sternberg Press (2013), 286 pp., Paperback, ISBN:
978-3-94336-594-8, €19.00
Audience as Subject, Yerba Buena Center for the Arts San Francisco: Yerba Buena Center for the Arts (2013), 142 pp., Paperback, ISBN: 978-0-98267-895-4, US$27.00
Visual Cultures as Seriousness, Gavin Butt and Irit Rogoff London and Berlin: Goldsmiths,
University of London and Sternberg Press (2013), 88 pp., Paperback, ISBN: 978-3-94336-539-9, £10.00
Artist-Run Spaces: Nonprofit Collective Organizations in the 1960s and 1970s, Gabriele Detterer and Maurizio Nannucci (eds) Zurich, Dijon and Florence: JRP|Ringier in co-edition with
Les Presses du reel and Zona (2012), 294 pp., Paperback, ISBN: 978-3-03764-191-0 (English)/978-2-84006-512-0 (French), €20.00
Outrage: Art, Controversy and Society, Richard Howells, Andreea Deciu Ritivoi and Judith Schachter (eds) New York: Palgrave Macmillan (2012), 352 pp., Hardcover,
ISBN: 978-0-23035-397-8, US$95.00