bluuebunny/crossref_metadata_2025_split huggingface dataset:
Argatroban in the management of heparin-induced thrombocytopenia: a multicenter clinical trial
Authors: Tardy-Poncet Brigitte , Nguyen Philippe , Thiranos Jean-Claude , Morange Pierre-Emmanuel , Biron-Andréani Christine , Gruel Yves , Morel Jérome , Wynckel Alain , Grunebaum Lelia , Villacorta-Torres Judith , Grosjean Sandrine , de Maistre Emmanuel 
Published: November 2015

Abstract
Introduction
The aim of this study was to collect data in France in patients with heparin-induced thrombocytopenia who required parenteral anticoagulation and for whom other non-heparin anticoagulant therapies were contraindicated including patients with renal failure, cross-reactivity to danaparoid or at high hemorrhagic risk.

Methods
A total of 20 patients, of mean age 72 ± 10 years, were enrolled in this open-label, multicenter clinical study. Exploratory statistical data analysis was performed with descriptive interpretation of intra-individual comparisons using simple univariate statistics.

Results
The diagnosis of HIT was confirmed in 16 subjects by an independent scientific committee. Fourteen patients (70 %) were in an intensive care unit during the course of the study. Patients were treated with argatroban for a mean duration of 8.5 ± 6.1 days. The mean starting dose of argatroban was 0.77 ± 0.45 μg/kg/min. Platelet recovery was rapid.
aPTT and anti-IIa activity assays were used to monitor the dose of argatroban. The mean baseline aPTT value was 45.0 ± 9.8 sec and increased to 78.2 ± 35.8 sec two hours after initiating argatroban. At this time mean argatroban concentration was 0.34 ± 0.16 and 0.61 ± 0.28 μg/ml using ECT and TT measurements, respectively. New and/or extended thromboses were reported in 25 % of patients and major bleedings were documented in 15 %. Six patients died due to their underlying medical condition.

Conclusion
Considering its hepatic elimination and its short half-life, argatroban can be considered as a safe therapeutic option in HIT patients at high hemorrhagic risk and with renal failure, particularly in an ICU setting.
Giant cavernous splenic haemangioma in a dog
Authors: Bendale Kiran , Desai Saral , Patil Asawari , Chaudhari Pradip , Talekar Shivaji , Gaikwad Rajeev , Chaudhari Devendra 
Published: November 2015

Case history: a nine-year-old male German Shepherd Dog presented with a history of progressively enlarged abdomen, shallow breathing and uncoordinated gait. A large abdominal mass, causing huge pressure on the surrounding organs and abdominal distension, was observed on physical examination. Imaging findings: contrast-enhanced computed tomography (CECT) showed two isoattenuating masses originating from the tail of the spleen, depicting hypoattenuating cystic areas with enhancement of solid structures on contrast administration: a characteristic finding of cavernous splenic haemangioma. The dog underwent a successful complete splenectomy and was followed up for next six months. Histopathology findings: haematoxylin and eosin staining showed vascular channels lined by well-differentiated endothelial cells with a low mitotic rate, suggestive of cavernous haemangioma. Immunohistochemical (IHC) staining was performed for CD34, vimentin, HMB-45, AE1/AE3 and epithelial membrane antigen; the expression of CD34 and vimentin endothelial markers confirmed the diagnosis of splenic haemangioma. Diagnosis: cavernous haemangioma of the spleen. Clinical relevance: it is rare to have a massive lesion on the spleen presenting as a giant abdominal mass in dogs. The location and nature of such a mass is difficult to diagnose by radiography and ultrasonography owing to its large size. CECT was found to be reliable to characterise the mass morphologically, and CT played a significant role in diagnosis and surgical management. The diagnosis was confirmed by IHC.
Readmission rates and financial penalties after ear, nose and throat surgery: how can we improve?
Authors: Danino JF , Taylor T , Metcalfe CW , Muzaffar SJ , Sinha A 
Published: November 2015

Introduction: Since April 2011, all patient readmissions within 30 days have resulted in a financial penalty to the hospital trust, and therefore the responsible department. These costs may be substantial and potentially preventable. Methods: A service evaluation of readmissions within 30 days of discharge, over a 12-month period (January–December 2012), was performed in the ear, nose and throat department of a district general hospital, and findings were used as a basis to suggest areas for potential quality improvement. Aims: To determine the number of readmissions, causes of readmission and resulting costs, and to explore how these readmissions may be prevented. Results: The departmental 30-day readmission rate over the study period was 3.12% (81/2606). The commonest causes of readmission (33.3%) were complications following tonsillectomy (27/81) such as pain, infection or bleeding. Over a third of these patients (30/81) were readmitted for less than 24 hours, with the average length of stay being less than 2.5 days. Financial implications: In 2011 the trust had 7526 emergency readmissions which were eligible for penalty within the 30-day time frame. This resulted in a loss of income of more than £60 000 to the ear, nose and throat department. Conclusions: Optimizing postoperative care and improving patient understanding of common complications may reduce readmission rates, thus limiting the financial burden on the trust. These areas could serve as a basis for future quality improvement projects.
Informal carers and wound management: an integrative literature review
Authors: Miller C. , Kapp S. 
Published: November 2015

Objective:The consequences of informal care giving have been well documented in recent decades, and in many fields of illness and chronic disease, the role of informal carers has been recognised and investigated. Informal caregivers in the field of wound management and prevention have been largely unnoticed, despite the chronic nature of many wounds, the enduring nature of treatments and the impact on the physical and social environment; factors likely to have a significant impact on family and friends. The aim of this study was to consider what published evidence is available regarding the experience and role of informal caregivers in wound management or prevention.Method:An integrated literature review was completed in October 2014 searching ESBCOhost database, Wound Management Association websites, and reviewing reference lists of accessed papers.Results:A number of challenges were noted in accessing information about informal carers in relation to wound management and prevention. Most of these arose from the scarcity of studies for which informal carers was the primary focus. The available evidence suggests that informal carers have a role in wound management and prevention and that their involvement is likely to represent a noteworthy economic contribution to the wound management health-care team. Wound management was also determined to yield physical and psychological impacts for the carer. There was limited evidence of structured information, support or training for informal carers, which was flagged by carers as an area of need.Conclusion:General conclusions about the burdensome experience and the valuable role of carers were the main interpretations possible from the evidence. More research which purposively and comprehensively examines the experience and role of informal caregivers is required. This knowledge would provide a foundation upon which interventions and support for informal carers and patients can be generated, which could further serve to enhance wound healing and the prevention of skin damage.
Measurement of diabetic wounds with optical coherence tomography-based air-jet indentation system and a material testing system
Authors: Choi M-C. , Cheung K-K. , Ng G. Y-F , Zheng Y-P. , Cheing G. L-Y. 
Published: November 2015

Objective:Material testing system is a conventional but destructive method for measuring the biomechanical properties of wound tissues in basic research. The recently developed optical coherence tomography-based air-jet indentation system is a non-destructive method for measuring these properties of soft tissues in a non-contact manner. The aim of the study was to examine the correlation between the biomechanical properties of wound tissues measured by the two systems.Method:Young male Sprague-Dawley rats with streptozotocin-induced diabetic were wounded by a 6 mm biopsy punch on their hind limbs. The biomechanical properties of wound tissues were assessed with the two systems on post-wounding days 3, 7, 10, 14, and 21. Wound sections were stained with picro-sirius red for analysis on the collagen fibres. Data obtained on the different days were charted to obtain the change in biomechanical properties across the time points, and then pooled to examine the correlation between measurements made by the two devices. Qualitative analysis to determine any correlation between indentation stiffness measured by the air-jet indentation system and the orientation of collagen fibres.Results:The indentation stiffness is significantly negatively correlated to the maximum load, maximum tensile stress, and Young's modulus by the material testing system (all p<0.05). The orientation of collagen changes with the indentation stiffness over time.Conclusion:Our findings support the use of optical coherence tomography-based air-jet indentation system to evaluate the biomechanical properties of wounds in a non-contact manner. It is a potential clinical device to examine the biomechanical properties of chronic wounds in vivo in a repeatable manner.
The use of a collagen matrix in hard-to-heal venous leg ulcers
Authors: Romanelli M. , Mulder G. , Paggi B. , Macchia M. , Panduri S. , Dini V. 
Published: November 2015

Objective: The effects of a collagen dressing on hard-to-heal venous leg ulcers (vlUs) were evaluated in this prospective, randomised, controlled study. Method: Patients with hard-to-heal vlU were included and divided into two groups using the block randomisation method. The first group was treated with a collagen and an alginate dressing (group A), and the second group with an alginate dressing alone (group b). both groups also had a short-stretch compression system applied at every dressing change. The dressings were changed twice a week for 12 weeks or until the ulcer was healed. Granulation tissue improvement, wound size, overall dressing performance and dressing comfort were evaluated and recorded. Results: A total of 40 patients completed the study evaluation period. Group A had a 65% increase in granulation tissue compared to 38% in group b. The mean ulcer area was reduced to 45% in group A compared to 20% in group b at 12 weeks. no significant side effects were detected in either group. Patients of both groups were satisfied with their treatment and healing progress. Conclusion: The results of this study showed the effectiveness and safety of a collagen dressing in hard-to-heal vlUs as an adjunctive therapy with compression bandaging. These encouraging results may positively affect the quality of life of patients with chronic wounds.
The Explosive Power And Speed Abilities Of Lower Extremities Of Young Basketball Players
Authors: Gallová Tatiana , Doležajová Ladislava , Lednický Anton , Matulaitis Kestutis , Bračič Mitja 
Published: November 2015

Summary
The authors compared selected somatic data and test results in 20 m sprint and countermovement jump (CJM) of 14-year-old Lithuanian players from Sabonis Center (LT, n=143; body height: 173.7 ± 8.99 cm; body mass: 59.30 ± 11.40 kg), and Slovenian (SLO, n=84; body height: 172.8 ± 9.96 cm; body mass: 60.10 ± 12.49 kg) and Slovak national team players (SVK, n=42, body height: 177.5 ± 9.07 cm; body mass: 63.32 ± 11.36 kg). The SVK players were divided into the narrow pick (A-team, n=16) and broader roster (B-team, n=26). Within the SVK groups, significant differences between the A-team and B-team have been found in terms of body height (p<0.05) and body mass measurements (p<0.01), and in the test 20 m sprint (p<0.05). In CMJ results, the differences of the A-team and B-team have not been statistically significant. In the international comparison SVK players were taller than SLO and LT players (p <0.05). In the test 20 m sprint SVK players have achieved significantly better results (LT p <0.05, SLO p <0.01). On the contrary, in CMJ test the results (height of the jump) of SVK players were significantly worse than SLO and LT players (p<0.01).
The Relative Age Effect On The Selection In The Slovakia National Football Teams
Authors: Mikulič Martin , Gregora Pavol , Benkovský Ľuboš , Peráček Pavol 
Published: November 2015

Summary
The focus of this research was to determine the relative age effect (RAE) on selection in the Slovakia national football teams. A factor that may have a significant impact on the quality of players chosen for the national teams or may result in a poor selection of players for the elite teams. Anthropometric and cognitive acceleration of players born in the first months of the calendar year concerning the overall context of the competition for placement in the national teams may be considered as a significant advantage. The aim of this research was to examine, determine and verify the presence of relative age effect in the selection of football players for the Slovakia national teams starting with the under 16 age category (U-16) through to the A - senior national football team. We presumed that the elite teams under this review and study consisted predominantly of players born in the first quarter of the calendar year, while also presuming that relative age effect receded with the increasing age category. Our survey sample U16 consisted of 79 players, U17 consisted of 47 players, U18 consisted of 58 players, U19 consisted of 71 players, U21 consisted of 52 players and A - senior national team consisted of 302 Slovakia national football players. The information obtained from the Slovak Football Association has been processed by the application of statistical methods and statistical significance test (T-test). Our research confirmed the presence of relative age effect in the U-16, U-17 and U-18 teams under our investigation (p≤0.01). In the U19 and U21 age categories, statistical significance has not been confirmed. As for the senior national team, statistically significant difference has been found in relation to players born in the last quarter of the year as opposed to players born in the first three months of the year (p≤0.01). Our results have shown that with the increasing age, the relative age effect fades and vanishes in full in the category of senior elite players. In the U-19 and U-21 age categories, statistical significance has not been confirmed. Based on this research results it may be recommended to use the advantage of relative age effect for the selection of players of the particular age category in the particular competition (such as e.g. the European Championship qualification, the European Championship final tournament qualification, or the World Cup qualification in the U-16, U-17, U-18 age categories).
Application Of CFD To Modeling Of Squeeze Mode Magnetorheological Dampers
Authors: Gołdasz Janusz , Sapiński Bogdan 
Published: November 2015

Abstract
The so-called squeeze flow involves a magnetorheological (MR) fluid sandwiched between two planar surfaces setting up a flow channel. The height of the channel varies according to a prescribed displacement or force profile. When exposed to a magnetic field of sufficient strength MR fluids develop a yield stress. In squeeze-mode devices the yield stress varies with both the magnetic field magnitude and the channel height. In this paper an unsteady flow model of an MR fluid in squeeze mode is proposed. The model is developed in Ansys Fluent R16. The MR material flow model is based on the apparent viscosity approach. In order to investigate the material's behaviour the authors prepared a model of an idealized squeeze-mode damper in which the fluid flow is enforced by varying the height of the channel. Using mesh animation, the model plate is excited, and as the mesh moves, the fluid is squeezed out of the gap. In the simulations the model is subjected to a range of displacement inputs of frequencies from 10 to 20 Hz, and local yield stress levels up to 30 kPa. The results are presented in the form of time histories of the normal force on the squeezing plate and loops of force vs. displacement (velocity).
Stress State Of Plate With Incisions Under The Action Of Oscillating Concentrated Forces
Authors: Shvabyuk Vasyl’ , Sulym Heorhiy , Mikulich Olena 
Published: November 2015

Abstract
This paper proposes the novel technique for analysis of dynamic stress state of multi-connected infinite plates under the action of oscillating forces. Calculation of dynamic stresses at the incisions of plates is held using the boundary-integral equation method and the theory of complex variable functions. The numerical implementation of the developed algorithmis based on the method of mechanical quadratures and collocation technique. The algorithm is effective in the analysis of the stress state caused by steady-state vibrations of plates.
Accuracy Of Positioning And Orientation Of Effector Of Planar Parallel Manipulator 3RRR
Authors: Prucnal-Wiesztort Monika 
Published: November 2015

Abstract
Parallel manipulator belongs to group of mechanisms with closed kinematic chains. This feature involves both advantages and disadvantages. The study examined the issue of accuracy of a planar system with three degrees of freedom, with revolute pairs, showing the effect of errors of the drives settings on effector positioning deviation. Enclosed is a numerical example for which analyzed the deviation in motion manipulator when going through the singular configuration. Based on the analysis was determined the area around the singular positions for which to obtain the orientation of the assumed accuracy is impossible.
Delamination Resistance Of Laminate Made With VBO MTM46/HTS Prepreg
Authors: Czarnocki Piotr , Czajkowska Kamila 
Published: November 2015

Abstract
A laminate made with the Vacuum Bag Only (VBO) prepregs can be cured out of autoclave. Because of low curing pressure such a process can result in deterioration of laminate mechanical properties. They can be significantly lower than those displayed by the autoclave cured ones. The resistance against delamination can be among the most affected. Since this property is a week point of all the laminates it was of particular interest. Delamination resistance of unidirectional laminate made from VBO MTM46/HTS(12K) prepreg was in the scope of the presented research and the critical values of the Strain Energy Release Rates and the Paris-type equations corresponding to Mode I, Mode II and Mixed-Mode I/II static and cyclic loadings, respectively, were determined.
Maximizing the Amount of Deposited Particles During a Severe Asthma Attack Using the Stochastic Lung Model
Authors: Zoltan Sarkany 
Published: November 2015

Abstract

Background: The aim of this study was to use a computerized lung model to simulate the deposition of inhaled particles in the human airways during a severe asthma attack, in order to find the combination of breathing- and particle-related parameters which leads to the highest deposited fractions in the target areas of the airways.

Material and Method: A stochastic lung model was used to simulate the deposition of 1 nm – 100 μm particles during a severe asthma attack in bronchial generations 9-16. Breathing parameters were chosen to reflect the use of a therapeutic inhalation device, with a 10 s symmetrical breathing cycle and 2000 ml tidal volume. To maximize the deposited fraction in the target areas, further simulations were carried out changing the tidal volume (750-3000 ml), the length of the breathing cycle (2-20 s) and the length of breathing pause following inhalation (0-10 s).

Results: The highest deposited fraction of 51.50% in bronchial generations 9–16 was obtained in the case of 0.01 μm particles, this value being more than4 times higher compared to the highest deposition of 3–6 μm particles currently used in inhalation devices (11.81% in the case of 5 μm particles). Modifying breathing-related parameters did not lead to valuable increases in the deposited fractions in the investigated region.

Conclusions: Deposition fractions in the therapeutically important areas of the airways may be more than4 times higher in the case of 0.01 μm particles, compared to particles currently used in the treatment of asthma bronchiale.
Food Consumption Frequency at Students from Rural Areas from Moldova Republic
Authors: Victor Zepca , Monica Tarcea , Aculina Zaporojan 
Published: November 2015

Abstract

Objective: Our study aim to evaluate the characteristics of nutrition behavior at teenagers from Moldova’s rural area schools in order to make a profile of risk behavior related to diet and to implement efficient community intervention programs.

Methods: We studied in 2014 the daily frequency consumption of the main food groups, in a sample of 1236 students of 7th-12th class, from rural localities of the Republic of Moldova, using the questionnaire method.

Results: The teenagers had consumed on the day preceding the interview, cereals and bakery products – 99.2%, fruits – 86.7%, cooked vegetables – 72.6%, meat dishes – 72.1%, potatoes – 50.3%, dairy products – 46.9%, raw vegetables – 44.7%, eggs – 25.3%, fish – 19.4%, raw fruits juice – 14.8%, legumes – 12.5% of students. From those investigated 52.6% have consumed food with high fat content higher than recommended levels. Regarding the food groups present in the menu we registered a satisfactory level of consumption by the students for cereals and bakery products, fruits, cooked vegetables and meat dishes; relatively satisfactory - the consumption of dairy products, raw vegetables and potatoes; unsatisfactory level for the consumption of eggs, fish and legumes.

Conclusions: We sustain the idea that it is important to constantly evaluate the risk factors related to the inadequate diet at teenagers and to implement efficient community intervention in order to prevent nutrition related diseases that can occur.
Specific Characteristics of Head and Neck Squamous Cell Carcinoma in Mures Area
Authors: Réka Fejér Enikő , Andrea Bodi , Imre Egyed-Zsigmond , Ioan Jung , Septimiu Voidăzan , Zoltán Ábrám 
Published: November 2015

Abstract
Although head and neck cancers have a rising incidence, these diseases are less investigated because of their localisations’ heterogenity. The major risk factors susceptible to influence the evolution of the disease are smoking, alcohol consumption and infection with human papilloma virus. Using data from Mures County Emergency Hospital’s histopathology register, we made a retrospective study of 190 cases from the last two years. Factors of interest included age, sex, localization, histopathological subtype and differentiation grade. Median age at diagnosis was 61.31 years, the disease presenting highest incidence in the 51-60 age subgroup and a clear male predominance (5.75:1). The most frequent localization is lower lip (28%) and the dominant histopathological subtype is cheratinised squamous cell carcinoma (83,8%) and G2 differentiation grade (48,1%). This study supports the finding of increased incidence of cheratinised squamous cell carcinoma in this region. However the literature emphasizes rising incidence of head and neck cancer in younger, we observed that increase in Mures area occurred in 51-60 age group. Lower lip most frequent localization makes possible an early diagnosis.