bluuebunny/crossref_metadata_2025_split huggingface dataset:
Archaeological textiles preserved by copper mineralization
Authors: Jia Rui , Zheng Hailing , Chen Haodong , Feng Min , Jiao Jinpeng , Kang Xiaojing , Yu Jianjun , Wang Bing , Zhang Zhaoxia , Zhou Yang , Peng Zhiqin 
Published: August 2024

Abstract
The mineralization mechanism responsible for the fossilization of archaeological textiles in close proximity to metal artifacts presents a sophisticated preservation process at both macro and micro levels. This study examines archaeological textiles dating from 2200 BC to AD 1900, sourced from three distinct archaeological sites. The focus is on understanding the microstructural degradation of fibers within a specific burial environment and the preservation achieved through mineralization. These archaeological fibers of archaeological textiles exhibit morphological preservation in the immediate vicinity of copper-based objects. Utilizing tools such as a digital camera, scanning electron microscopy with energy dispersive spectroscopy (SEM–EDS), high-resolution synchrotron-based microtomography (μCT), and enzyme-linked immunosorbent assay (ELISA), we examined fiber morphology, conducted elemental analysis, identified fiber types, and analyzed fiber characteristics. Our findings reveal the presence of smooth-surfaced wools and silks, fibers covered with calculi, and fiber impressions—all subjected to mineralization. These mineralized fibers can be categorized into three distinct stages of mineralization, each exhibiting varying carbon content. We inferred a correlation between mineralization rate and carbon content while also identifying mineralization density distribution on these textiles. Lastly, this study provides insights into the preservation states of textiles across three different mineralization stages, enriching our understanding of the deterioration of organic archaeological material.
Construction and optimization of a genetic transformation system for efficient expression of human insulin-GFP fusion gene in flax
Authors: Zhao Wei , Zhang Rui , Zhou Luyang , Zhang Zhongxia , Du Fei , Wu Ruoyu , Kong Jing , An Shengjun 
Published: August 2024

AbstractThe human insulin gene modified with a C-peptide was synthesized according to the plant-preferred codon, and a fusion gene expression vector of insulin combined with green fluorescent protein (GFP) was constructed. The optimization of the flax callus culturing was undertaken, and a more efficient Agrobacterium-mediated genetic transformation of the flax hypocotyls was achieved. The critical concentration values of hygromycin on the flax hypocotyl development, as well as on its differentiated callus, were explored by the method of antibiotic gradient addition, and the application of antibiotic screening for the verification of positive calluses was assessed. The fusion gene of insulin and GFP was successfully inserted into the flax genome and expressed, as confirmed through polymerase chain reaction and Western blotting. In conclusion, we have established a flax callus culture system suitable for insulin expression. By optimizing the conditions of the flax callus induction, transformation, screening, and verification of a transgenic callus, we have provided an effective way to obtain insulin. Moreover, the herein-employed flax callus culture system could provide a feasible, cheap, and environmentally friendly platform for producing bioactive proteins.
Graphical Abstract
Smart automated highway lighting system using IoT: a survey
Authors: Achar Tejaswini Eshwar , Rekha C. , Shreyas J. 
Published: August 2024

AbstractEfficient highway lighting is crucial for ensuring road safety and reducing energy consumption and costs. Traditional highway lighting systems rely on timers or simple photosensors, leading to inefficient operation by illuminating lights when not needed or failing to adjust to changing conditions. The emergence of the Internet of Things (IoT) and related technologies has enabled the development of smart automated highway lighting systems that can dynamically control illumination levels based on real-time data. This paper provides a comprehensive review of the current state-of-the-art in smart automated highway lighting systems employing IoT technologies. Key components, communication protocols, data processing techniques, and lighting control strategies are discussed. The integration of renewable energy sources and energy storage systems is explored for environmentally sustainable operations. Practical implementation case studies are analyzed to highlight benefits and challenges. Open research issues and future directions for further enhancements are identified.
Characterization of a conductive hydrogel@Carbon fibers electrode as a novel intraneural interface
Authors: Giannotti Alice , Santanché Ranieri , Zinno Ciro , Carpaneto Jacopo , Micera Silvestro , Riva Eugenio Redolfi 
Published: August 2024

AbstractPeripheral neural interfaces facilitate bidirectional communication between the nervous system and external devices, enabling precise control for prosthetic limbs, sensory feedback systems, and therapeutic interventions in the field of Bioelectronic Medicine. Intraneural interfaces hold great promise since they ensure high selectivity in communicating only with the desired nerve fascicles. Despite significant advancements, challenges such as chronic immune response, signal degradation over time, and lack of long-term biocompatibility remain critical considerations in the development of such devices. Here we report on the development and benchtop characterization of a novel design of an intraneural interface based on carbon fiber bundles. Carbon fibers possess low impedance, enabling enhanced signal detection and stimulation efficacy compared to traditional metal electrodes. We provided a 3D-stabilizing structure for the carbon fiber bundles made of PEDOT:PSS hydrogel, to enhance the biocompatibility between the carbon fibers and the nervous tissue. We further coated the overall bundles with a thin layer of elastomeric material to provide electrical insulation. Taken together, our results demonstrated that our electrode possesses adequate structural and electrochemical properties to ensure proper stimulation and recording of peripheral nerve fibers and a biocompatible interface with the nervous tissue.
Theoretical analysis and technical application of mechanical intelligent manufacturing based on system digital-driven technology
Authors: Li Guo , Qin Yi , Wang MingHua 
Published: August 2024

AbstractWith the accelerating process of global industrialization, the automated fabrication industry, as an important part of the industry, is also developing rapidly. Due to the low efficiency and high resource consumption of traditional manufacturing, it is more important to improve the production efficiency of conventional manufacturing and realize the resource-saving development mode. Due to the characteristics of system digital-driven technology, it can promote the intelligent development of the manufacturing industry. Therefore, the deep integration of system digital-driven technology and manufacturing is conducive to the intelligent promotion of manufacturing. Comparing the difference between the traditional manufacturing industry and the intelligent manufacturing industry, the application potential of system digitalization technology in the manufacturing field is analyzed. Based on the analysis of the theoretical basis of the system digital-driven technology and the application of the system digital technology in the main fields, the importance of the technology for the improvement of the accuracy index in the manufacturing process is emphatically analyzed. The maximum increase can be 5.3%, and the minimum increase can be 3.3%. It can be seen that the deep integration of digital-driven technology and manufacturing can not only improve the intelligent level of manufacturing, realize the intensive development of the industry, but also realize the data sharing of the entire industrial chain.
‘Comorbidity, Co-Pathology and Confusion’: The Critical Importance of the ADHD - Anxiety Disorders Relationship
Authors: Anand S. , Kapoor S. , Arora I. 
Published: August 2024

IntroductionGiven the widespread prevalence of ADHD and Axniety Disorders, and their obvious impact on mood, cognitions, individual productivity, interpersonal relationships and self-esteem, accurate diagnosis and treatment of these disorders should rightly be considered paramount. ADHD shares several co-morbidities (including and especially the anxiety disorders). With the decades-long rise in the number of stimulant prescriptions, the increasing number of self-report measures, and ‘confusing’ DSM-5 criteria, concerns remain as to how accurately ADHD and/or anxiety disorders are actually being diagnosed and treated, especially when comorbid with one another.This presentation seeks to highlight the downstream consequences of overdiagnosis, underdiagnosis and missed diagnoses when it comes to both Anxiety disorders and ADHD. Its overarching aim is to offer clinicians a ‘roadmap’ through the ADHD and Anxiety Disorders diagnostic and treatment ‘maze’. A pragmatic, guided evaluation of symptoms and functionality is outlined, striving for improved clinical understanding of how ADHD and Anxiety Disorders (when co-morbid) actually affect each other and whether they are, in fact, related disorders.ObjectivesParticpants will be expected to have a more solid understanding of:The extent and ramifications of underdiagnosis, missed diagnoses and overdiagnosis with respect to Anxiety Disorders and ADHD, as result of current DSM-5 diagnostic criteria, common clinical pitfalls and assumptions, as well as clinician biases.How ADHD and Anxiety disorders can affect the presentation and prognosis of the corresponding comorbid disorder.How clinicians should approach these two disorders (whether comorbid or not) in order to facilitate effective individualized treatment.The hypotheses and evidence that ADHD and anxiety are different or that they are related subtypes of the same endophenotype.The circuitry of. and inputs to, the Prefrontal Cortex and how this can be usefully applied in clinical practice.Methods1.Literature Review of electronic research databases to include: PubMed, Google Scholar, and PSYCHINFO2.Review of statistics of prevalence, incidence of the above two disorders, and number.type of prescriptions for ADHD and anxiety worldwide derived from the above as well as the CDC and NIMH3.Review of existing North American, European and Australasian treatment guidelines as well as expert consensus recommendations for ADHD, Anxiety Disorders, as well as both disorders when comorbid with one another.ResultsTo be provided by the presenters via Powerpoint slides at the open panel discussionConclusionsTo be provided and discussed at the open panel discussionDisclosure of InterestNone Declared
Unraveling a Psychiatric Puzzle: Corticosteroid-Induced Psychosis in Addison’s Disease. A case report
Authors: Mayor Sanabria F. , Fernández Fariña M. , Expósito Durán M. E. , Regueiro Martín-Albo C. E. , Arroyo Del Val C. , Paz Otero M. , Alberdi Páramo Í. 
Published: August 2024

IntroductionThe spectrum of neuropsychiatric adverse effects of corticosteroids ranges from unspecific symptoms to structured psychotic or affective episodes. We present the case of a 30-year-old woman admitted to our hospital due to behavioral alterations, coinciding with the initiation of treatment with corticosteroid boluses as part of a chemotherapy regimen for gastric adenocarcinoma. She had a previous diagnose of Addison’s disease, undergoing treatment with supplemental corticosteroids.Objectives1)To describe the clinical particularities of this case, focusing on the psychopathological aspects and their correlation with the corticoid treatment.2)To review the available literature regarding the clinical characteristics and management of corticosteroid-induced psychosis, with special interest in patients with adrenal insufficiency that require long term steroid supplementation.MethodsA review of the patient’s clinical history and complementary tests were carried out. Likewise, we reviewed the available literature in relation to the clinical presentation of corticosteroid-induced psychosis and its pharmacological management.ResultsThe patient was admitted to our hospital due to acute behavioural alterations, which temporally coincided with the 4th cycle of FOLFOX chemotherapy and corticosteroid boluses. She presented with incoherent speech, with non sequitur answers and glossolalia, as well as dysphoric affect and purposeless behavior. She presented a favorable clinical course after the initiation of treatment with antipsychotics and temporary suspension of corticosteroid treatment.Manic symptoms are the most common presentation of “corticosteroid-induced psychosis”, with the key characteristic being the temporal association with the corticosteroids administration. Although the discontinuation of steroids generally results in a sudden decrease in symptoms, additional treatment with antipsychotics such as haloperidol or olanzapine might be required for a symptomatic control. In patients with adrenal insufficiency, long-term treatment with lithium or anti-seizure treatments are effective strategies in relapse prevention when a higer steroid dose is required.Conclusions-Corticosteroid-induced psychosis is a well described clinical phenomenon, that usually presents with manic symptoms rather than psychotic experiences.-Progressive discontinuation of corticosteroid treatment usually results in complete cessation of symptoms, but additional psychopharmacological treatment might be required, especially in patients with adrenal insufficiency undergoing long-term corticosteroid treatment.-This case outlines the psychopathological richness in the presentation of corticosteroid-induced psychosis, and illustrates the challenges in the pharmacological management in patients with adrenal insufficiency.Disclosure of InterestNone Declared
Antipsychotics and delirium: When to start and what to select
Authors: Stoppe G. 
Published: August 2024

AbstractAntipsychotics are among the substances that are very frequently used for elderly people and dementia patients in particular. This is known from studies both in outpatient care and in nursing homes. They are often part of a polypharmacy. This group of substances is discussed in the context of the increased risk of falls, increased mortality and also - as here - in the context of the development of delirium.On the other hand, antipsychotics are drugs for the treatment of delirium, whereby the question of their significance in modern delirium treatment is being asked anew. In the past, butyrophenones in particular have played a role here, partly because of their variable form of administration and also because of their low cardiac impact.In the context of delirium prevention, the aim is to reduce the number of drugs on the one hand and the anticholinergic load of the drugs on the other. Algorithms and recommendations exist for this.In the treatment of delirium, the focus is rightly placed primarily on non-pharmacological management. The use of antipsychotics should be reserved for severe states of agitation or agitation in the context of delirium. In other cases, careful judgement is required.Disclosure of InterestNone Declared
Elevated Soluble ST2 Blood Levels in Patients with Depression and Comorbid Heart Failure: A Correlative Study
Authors: Sikora A. K. , Fedorov S. 
Published: August 2024

IntroductionDepressive disorders frequently coexist with chronic medical conditions like heart failure (HF), significantly impacting patients’ overall health and quality of life. This study aims to explore the correlation between soluble ST2 molecule levels and the presence of depressive disorders in patients with heart failure.ObjectivesA total of 200 patients, all diagnosed with heart failure, were included in this study. Among them, 30 patients were mentally healthy, and the remaining 170 exhibited medium-level depressive disorders. Blood samples were collected and analyzed for soluble ST2 levels to assess the potential correlation between depressive disorders and soluble ST2 levels in patients with heart failure.MethodsA total of 200 patients, all diagnosed with heart failure, were included in this study. Among them, 30 patients were mentally healthy, and the remaining 170 exhibited medium-level depressive disorders. Blood samples were collected and analyzed for soluble ST2 levels to assess the potential correlation between depressive disorders and soluble ST2 levels in patients with heart failure.ResultsThe study demonstrated a statistically significant finding, indicating that the levels of soluble ST2 were 1.6 times higher in patients with depression and comorbid heart failure compared to mentally healthy individuals with heart failure.ConclusionsThis study elucidates a statistically significant correlation between medium-level depressive disorders and elevated soluble ST2 levels in patients with coexisting heart failure, shedding light on the potential role of soluble ST2 as a biomarker in identifying and managing depressive disorders in heart failure patients. The observed 1.6-fold increase in soluble ST2 levels in heart failure patients with depression emphasizes the importance of mental health assessment and intervention in individuals with chronic medical conditions, particularly heart failure, to enhance overall care and outcomes.Disclosure of InterestNone Declared
Late-onset mania as a manifestation of neurosyphilis: A Case Report
Authors: Labyadh A. , Omri S. , Haouari W. , Gassara I. , Feki R. , Smaoui N. , Zouari L. , Ben thabet J. , Maalej M. , Charfi N. , Maalej Bouali M. 
Published: August 2024

IntroductionThe evaluation of manic behavior with later onset is crucial, as various organic factors such as medications, infections, metabolic disturbances, tumors, and epilepsy can serve as potential etiological causes. While not universally observed, most studies indicate a connection between late-onset mania and neurological disorders like neurosyphilis.ObjectivesOur study aims to investigate the relationship between late-onset mania and neurosyphilis.MethodsIn this paper, we present a case of neurosyphilis presenting exclusively with symptoms of mania.ResultsA 72-year-old Tunisian woman with no prior medical or psychiatric history was referred to the psychiatric emergency room due to alterations in her mental state and behavior over the past ten days. During the psychiatric assessment, she displayed increased motor activity, fluctuating emotions, and rapid flow of ideas. The general physical examination yielded no notable findings. The serum Venereal Disease Research Laboratory (VDRL) test returned a strongly positive result (+++), and the TPHA examination confirmed a positive result at a titer of 1/60. In the serologic analysis of cerebrospinal fluid, VDRL was also positive, thereby confirming the diagnosis of neurosyphilis (NS). The diagnosis of mania secondary to a medical condition was established. The patient was treated with ceftriaxone and antimanic medications, resulting in a significant improvement in her psychiatric symptoms within a few days.ConclusionsThis case underscores the importance of conducting serologic testing for syphilis in patients who present with manic symptoms, experience a late-onset mental disorder, and have no prior history or family history of affective disorders.Disclosure of InterestNone Declared
Personalization of therapy of psychopathological complications of cardiac surgery in artificial circulation conditions
Authors: Markova M. , Mankovsky D. , Abdriakhimova T. 
Published: August 2024

IntroductionThe study of the clinical and phenomenological features of psychopathological complications of cardiac surgery (CS) in artificial circulation conditions (ACC), the development of modern approaches to early diagnosis and prognosis of psychopathology is an effective way to solve this problem has valid medical and social significance.ObjectivesTo increase the effectiveness of prevention of psychopathological disorders in cardiosurgical interventions based on personalization of their correction.MethodsThe examination included the use of socio-demographic, instrumental, biochemical, clinical-psychopathological, psychometric, and statistical methods.ResultsThe study sample consisted of 700 patients who were treated by CS in ACC at the SI “Heart Institute of the MH of Ukraine”.It was found out that the most common complication is postsurgeon cognitive dysfunction (PCD) (72.0% of patients), postsurgeon encephalopathy (PE) (31.0%) is less common, and cerebral infarction (CI) is the least common (12.2%).It was revealed that the core psychopathological symptoms associated with CS are cognitive disorders (72.0% of the examined) and affective symptoms, represented by depressive (38.1%) and anxiety (33.9%) manifestations of mild and moderate expressiveness, and auxiliary constructs – dyssomnic (29.7%), asthenic (17.9%) and somatovegetative (9.0%) disorders. The highest prevalence of psychopathological symptoms was found in patients with CI, somewhat less in patients with PE, and the lowest in patients with PCD.Signs of mild depressive disorder were found in patients who underwent CS in ACC, elevated levels of adynamic depression indicators, depression with fear and agitated depression, as well as increased levels of anxiety: the average level of anxiety, mental and somatic anxiety. The indicators of expressiveness of depression and anxiety in patients with CI turned out to be the highest, in patients with PE – lower, and in patients with PCD – the lowest.We proposed a mathematical model for predicting the development of psychosocial maladjustment (PM) in patients who have undergone CS in ACC. It is based on a comprehensive assessment of three key vectors that can have a mutually potentiating pathogenetically related effect on the course of the formation of PM: surgical, neurological, and psychopathological. A complex of diagnostic, corrective and preventive measures for each of the risk groups has been developed.ConclusionsVerification of the proposed model on a representative sample of patients confirmed its high predictive ability and reliability in use.Disclosure of InterestNone Declared