bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Pain Sensitivity on the Treatment Outcome of Transforaminal Epidural Steroid Injection in Patients with Lumbar Spinal Stenosis
Authors: Kim Ho‐Joong , Yeom Jin S. , Lee Joon Woo , Chang Bong‐Soon , Lee Choon‐Ki , Lee Gun‐Woo , Im Seung‐Bin , Kim Han Jo 
Published: June 2013

AbstractThe aim of this study was to investigate the effect of individual pain sensitivity on the results of transforaminal epidural steroid injection (TFESI) for the patients with lumbar spinal stenosis (LSS). Seventy‐seven patients with LSS were included in this study. Prospectively planned evaluations were performed twice consecutively before and 2 months after TFESI. These included a detailed medical history, a physical examination, and completion of a series of questionnaires, including pain sensitivity questionnaire (PSQ), Oswestry disability index (ODI), and visual analog scale (VAS) for back and leg pain. The correlations were analyzed among variables between total PSQ/PSQ‐moderate/PSQ‐minor and pain and disability level measured by VAS for back/leg pain and ODI both before and 2 months after TFESI. Two months after TFESI, there were significant decreases in VAS for back/leg pain and ODI compared with those before injection. Before injection, VAS for back pain and leg pain was highly associated with the PSQ scores including total PSQ and PSQ subscores after adjustment for age, BMI, and grade of canal stenosis. However, any subscores of PSQ and total PSQ scores were not correlated with either VAS for back pain/leg pain or ODI 2 months after TFESI with adjustment made to age, BMI, gender, and grade of canal stenosis. This study highlights that individual pain sensitivity does not influence the outcomes of TFESI treatment in patients with LSS, even though pain sensitivity has a significant negative correlation with symptom severity of LSS.
Diapause and cold tolerance inAsian species of the parasitoidLeptopilina(Hymenoptera:Figitidae)
Authors: MURATA YUSUKE , NOVKOVIĆ BILJANA , SUWITO AWIT , KIMURA MASAHITO T. 
Published: June 2013

AbstractDiapause and cold tolerance are essential for temperate insects to pass the winter, with the mechanisms controlling these two traits varying considerably among insects. In the present study, diapause and cold tolerance are compared among threeLeptopilinaspecies:Leptopilina japonicaNovković & Kimura,Leptopilina victoriaeNordlander andLeptopilina ryukyuensisNovković & Kimura, all larval parasitoids of frugivorous drosophilid flies, with the aim of understanding their climatic adaptations. The first species is divided into the temperate (Leptopilina japonica japonica) and subtropical subspecies (Leptopilina japonica formosana), and the latter two species are distributed in the tropical and subtropical regions. The temperate subspecies ofL. japonicaenters prepupal diapause at low temperatures (15 or 18 °C), irrespective of photoperiod, and some individuals enter diapause when exposed to 0 °C for 1 or 2 day(s) or when placed at low humidity.Leptopilina victoriaealso shows signs of diapause initiation at 15 °C, althoughL.ryukyuensisandL. j. formosanafrom the subtropical regions do not. Preimaginal viability at low temperature (13, 14 or 15 °C) is usually lower inL. victoriaefrom the tropical regions compared withL. japonicaorL. ryukyuensisfrom the temperate or subtropical regions. Diapausing prepupae of the temperate subspecies appear to be cold tolerant. However, the cold tolerance of nondiapausing prepupae, pupae and adult females varies little among the tropical, subtropical and temperate species or subspecies, and adult males of the temperate subspecies ofL. japonicaare less cold tolerant than those of the tropical or subtropical species or subspecies. Cold tolerance may be unnecessary, except for diapausing individuals of the temperate species, because nondiapausing individuals appear in warmer seasons.
Context heterogeneity has a sustained impact on attention deployment: Behavioral and electrophysiological evidence
Authors: Feldmann‐Wüstefeld Tobias , Wykowska Agnieszka , Schubö Anna 
Published: June 2013

AbstractIn visual search, similar nearby stimuli can be grouped and thus enhance processing of an embedded target. The aim of the present study was to examine the time course of attention deployment after a brief presentation of stimulus arrays of different heterogeneity. Targets in less heterogeneous, grouped contexts yielded higher accuracy and larger N2pc amplitudes than targets in more heterogeneous, random contexts, indicating more efficient selection in the former. Subsequently presented probes yielded shorter reaction times and a larger posterior positivity when presented at the target location. This advantage was more pronounced after grouped compared to random contexts at the shorter compared to the longer interstimulus interval. The results show that less heterogeneous contexts that allow for grouping not only enhance processing of stimuli within that context, but have a sustained effect on visual attention.
Necrolytic migratory erythema associated with a glucagon‐producing primary hepatic neuroendocrine carcinoma in a cat
Authors: Asakawa Midori G. , Cullen John M. , Linder Keith E. 
Published: June 2013

BackgroundIn humans, necrolytic migratory erythema (NME) is a syndrome with a characteristic skin rash that is associated most often with a pancreatic glucagonoma and is recognized as part of the glucagonoma syndrome. In veterinary medicine,NME(also called as superficial necrolytic dermatitis, hepatocutaneous syndrome or metabolic epidermal necrosis) has been described in dogs in association with chronic liver diseases or, less frequently, glucagonoma, butNMEassociated with glucagonoma has not previously been reported in cats.Case reportA 6‐year‐old male neutered domestic short hair cat was diagnosed withNMEassociated with a glucagon‐producing primary hepatic neuroendocrine carcinoma (hepatic carcinoid). The cat presented with a 2 week history of vomiting and anorexia, and a 5‐cm‐diameter liver mass was detected by abdominal ultrasound. The cat exhibited general weakness, crusted skin lesions and pain in all four limbs. It was euthanized 11 months after the initial presentation. Histopathological review of the paw pads revealed the classic ‘red, white and blue’ lesion composed of parakeratotic hyperkeratosis, epidermal hydropic change and hyperbasophilia of the deep epidermis. The liver mass was diagnosed as a neuroendocrine carcinoma (hepatic carcinoid). Neoplastic cells were strongly immunoreactive for glucagon.Conclusion and clinical importanceThis is the first case report ofNMEassociated with a glucagon‐producing primary hepatic neuroendocrine carcinoma in a cat.
Intraocular sarcoma associated with a rupture lens in a rabbit (Oryctolagus cuniculus)
Authors: Dickinson Ryan , Bauer Bianca , Gardhouse Sara , Grahn Bruce 
Published: June 2013

AbstractThis case report describes the clinical manifestations and ocular pathology of an intraocular sarcoma in a spayed female 7‐year‐old rabbit that developed clinical signs consistent with phacoclastic uveitis at 6 months of age, which was left untreated for most of the next 6 years. Ophthalmologic examination confirmed pupillary occlusion, aqueous flare, fibrin, and lens debris within the anterior chamber of the right eye. The right eye was blind and phthisical. The tentative clinical diagnosis was chronic phacoclastic uveitis, and a routine transconjunctival enucleation of the right eye was completed. The globe was formalin‐fixed and submitted for histologic examination. Light microscopic examination revealed a ruptured cataractous lens, uveitis, retinal detachment, and an intraocular sarcoma centered around the lens. Immunohistochemical (IHC) staining was positive for smooth muscle actin and vimentin and negative for Desmin and cytokeratin intermediate filaments.
Ocular comparative anatomy of the family Rodentia
Authors: Rodriguez‐Ramos Fernandez Julia , Dubielzig Richard R. 
Published: June 2013

AbstractThere is little information regarding ocular anatomy and histology in many of the rodent species. Histological analyses for morphologic features were performed in 31 globes from 18 rodent species submitted to and archived at the Comparative Ocular Pathology Laboratory of Wisconsin. The following measurements were taken: thickness of the cornea, corneal epithelium, corneal stroma, Descemet's membrane, and retina. H&E sections were evaluated for the following anatomical features: presence of pigmented epithelial cells in the peripheral cornea, presence and location of Schlemm's canal, presence of iridal sphincter and dilator and ciliary body muscles, presence of pars plicata and plana, presence of retinal vessels, presence of lamina cribrosa, and presence of tapetum lucidum. The springhaas was the only rodent in our collection that presented a well‐developed tapetum lucidum fibrosum. The presence of retinal vessels was variable: vessels were observed in all of the members of the mouse‐related clade, except the springhaas and the beaver, in all of the squirrel‐related clade members, and in none of the Ctenohystrica. In the flying squirrels, blood vessels extended to the outer limiting membrane in the photoreceptor layer. Beavers, chinchillas, capybara, and guinea pigs lacked vessels within the retina; however, they had vessels within the optic nerve head. Ground squirrels have an optic nerve head, which is linear in the horizontal plane and an asymmetric retina. The tree‐dwelling squirrels have a rounded but still elongated optic nerve, and the flying squirrel has a round optic nerve head like all the other rodents.
Serological Survey of Veterinarians to Assess the Zoonotic Potential of Three Emerging Swine Diseases in Mexico
Authors: Rivera‐Benitez J. F. , Rosas‐Estrada K. , Pulido‐Camarillo E. , de la Peña‐Moctezuma A. , Castillo‐Juárez H. , Ramírez‐Mendoza H. 
Published: June 2013

SummaryWe conducted an immunological assay of blood samples taken from 85 swine‐specialist veterinarians attending the Congress of the Mexican Association of Swine Specialist Veterinarians in Mexico in 2011. Serum samples were assayed for Porcine rubulavirus (PorPV), Encephalomyocarditis virus (EMCV) and Leptospira spp. antibodies. Using a hemagglutination inhibition test, we registered 2.3% and 27% seropositivity for PorPV and EMCV, respectively. Using viral neutralization tests, we registered 5.8% and 47% seropositivity for PorPV and EMCV, respectively. For Leptospira spp., we registered a seropositivity of 38.8%. The variables (sex, age, years of exposure, number of visited farms, biosecurity level and region) showed no significant effect (P > 0.05) on the seropositivity for EMCV, PorPV and Leptospira spp. except for number of visited farms on HI seropositivity for EMCV (P < 0.05; odds ratio: 1.38). The data obtained provide information on the epidemiology of emerging diseases with zoonotic potential in occupational risk groups.
Sustained reductions in emergency department laboratory test orders: impact of a simple intervention
Authors: Chu Kevin H , Wagholikar Amol S , Greenslade Jaimi H , O'Dwyer John A , Brown Anthony F 
Published: June 2013

Abstract

Objectives
To determine whether a pathology request form allowing interns and residents to order only a limited range of laboratory blood tests prior to consultation with a registrar or consultant can reduce test ordering in an emergency department (ED).

Methods
A prospective before-and-after study in an adult tertiary-referral teaching hospital ED was conducted. A pathology request form with a limited list of permissible tests was implemented for use by junior medical officers. Tests for patients 16 years and older presenting in a 20-week pre-intervention period from 19 January 2009 were compared with those in a corresponding 20-week post-intervention period from 18 January 2010. Main outcome measures were the number and cost of blood tests ordered.

Results
24 652 and 25 576 presentations were analysed in the pre- and post-intervention periods, respectively. The mean number of blood tests ordered per 100 ED presentations fell by 19% from 172 in the pre- to 140 in the post-intervention period (p=0.001). The mean cost of blood tests ordered per 100 ED presentations fell by 17% from $A3177 in the pre- to $A2633 in the post-intervention period (p=0.001). There were falls in the number of coagulation profiles (11.1 vs 4.8/100 patients), C-reactive protein (5.6 vs 2.7/100 patients), erythrocyte sedimentation rate (2.5 vs 1.3/100 patients) and thyroid function tests (2.2 vs 1.6/100 patients).

Conclusions
Pathology request forms limiting tests that an intern and resident may order prior to consultation with a registrar or consultant are an effective low maintenance method for reducing laboratory test ordering in the ED that is sustainable over 12 months.
Postcastration analgesia in ponies using buprenorphine hydrochloride
Authors: Love E. J. , Taylor P. M. , Whay H. R. , Murrell J. 
Published: June 2013

Buprenorphine has recently obtained UK Marketing Authorisation for horses. The analgesic effects are long lasting, and have considerable potential for postoperative pain relief. This observer blinded, randomised study aimed to evaluate postsurgical analgesia in ponies premedicated with buprenorphine prior to castration under intravenous anaesthesia. Ponies received either 0.01 mg/kg bodyweight (BW) buprenorphine (group B) or an equivalent volume of 5 per cent glucose (group C) given intravenously before induction of anaesthesia. Pain was assessed and recorded using dynamic interactive visual analogue scores (DIVAS 0–100) and a Simple Descriptive Scale (SDS 0–3) (high scores=most pain) before and 1, 3, 6, 9, 12 and 24 hours after anaesthesia. Rescue analgesia was given if DIVAS>40 mm. Data were analysed using the Mann‐Whitney U test at P<0.05. Median (range) areas under the curve for DIVAS were 63 (0–383) mm hour in group B and 209 (0–391) mm hour in group C (P=0.0348). The SDS was lower in group B than in group C (P=0.038). Three group B and five group C animals required rescue analgesia. Buprenorphine did not produce any serious adverse effects. Buprenorphine at 0.01 mg/kg BW intravenously administered before anaesthesia provided near‐comprehensive postoperative analgesia after surgical castration in ponies.
Word Sense Disambiguation by Combining Labeled Data Expansion and Semi-Supervised Learning Method
Authors: Fujita Sanae , Fujino Akinori 
Published: June 2013

Lack of labeled data is one of the severest problems facing word sense disambiguation (WSD). We overcome the problem by proposing a method that combines automatic labeled data expansion (Step 1) and semi-supervised learning (Step 2). The Step 1 and 2 methods are both effective, but their combination yields a synergistic effect.
In this article, in Step 1, we automatically extract reliable labeled data from raw corpora using dictionary example sentences, even the infrequent and unseen senses (which are not likely to appear in labeled data). Next, in Step 2, we apply a semi-supervised classifier and achieve an improvement using easy-to-get unlabeled data. In this step, we also show that we can guess even unseen senses.
We target a SemEval-2010 Japanese WSD task, which is a lexical sample task. Both Step 1 and Step 2 methods performed better than the best published result (76.4 %). Furthermore, the combined method achieved much higher accuracy (84.2 %). In this experiment, up to 50 % of unseen senses are classified correctly. However, the number of unseen senses are small, therefore, we delete one senses per word and apply our proposed method; the results show that the method is effective and robust even for unseen senses.
Network Formation in the Presence of Contagious Risk
Authors: Blume Lawrence , Easley David , Kleinberg Jon , Kleinberg Robert , Tardos Éva 
Published: June 2013

There are a number of domains where agents must collectively form a network in the face of the following trade-off: each agent receives benefits from the direct links it forms to others, but these links expose it to the risk of being hit by a cascading failure that might spread over multistep paths. Financial contagion, epidemic disease, the exposure of covert organizations to discovery, and electrical power networks are all settings in which such issues have been articulated.
Here we formulate the problem in terms of strategic network formation, and provide asymptotically tight bounds on the welfare of both optimal and stable networks. We find that socially optimal networks are, in a precise sense, situated just beyond a phase transition in the behavior of the cascading failures, and that stable graphs lie slightly further beyond this phase transition, at a point where most of the available welfare has been lost. Our analysis enables us to explore such issues as the trade-offs between clustered and anonymous market structures, and it exposes a fundamental sense in which very small amounts of “over-linking” in networks with contagious risk can have strong consequences for the welfare of the participants.
Optimal Auctions with Positive Network Externalities
Authors: Haghpanah Nima , Immorlica Nicole , Mirrokni Vahab , Munagala Kamesh 
Published: June 2013

We consider the problem of designing auctions in social networks for goods that exhibit
single-parameter submodular network externalities
in which a bidder’s value for an outcome is a fixed private type times a known submodular function of the allocation of his friends. Externalities pose many issues that are hard to address with traditional techniques; our work shows how to resolve these issues in a specific setting of particular interest. We operate in a Bayesian environment and so assume private values are drawn according to known distributions. We prove that the optimal auction is NP-hard to approximate pointwise, and APX-hard on average. Thus we instead design auctions whose revenue approximates that of the optimal auction. Our main result considers
step-function externalities
in which a bidder’s value for an outcome is either zero, or equal to his private type if at least one friend has the good. For these settings, we provide a
e
/
e
+ 1-approximation. We also give a 0.25-approximation auction for general single-parameter submodular network externalities, and discuss optimizing over a class of simple pricing strategies.
Systematic evaluation of workload clustering for extremely energy-efficient architectures
Authors: Guha Apala , Zhang Yao , ur Rasool Raihan , Chien Andrew A. 
Published: June 2013

Chip power consumption has reached its limits, leading to the flattening of single-core performance. We propose the 10x10 processor, a federated heterogeneous multi-core architecture, where each core is an ensemble of u-engines (micro-engines, similar to accelerators) specialized for different workload groups to achieve dramatically higher energy efficiency. The u-engines collectively target the entire general-purpose workload space.
The problem we study in this article is selecting the set of workloads that each u-engine should be customized for. For this problem we study the computation structure of a wide variety of workloads and cluster together workloads with similar computation structures, the idea being that each u-engine will be customized for the compute structures exhibited by a particular cluster. The constraint on this problem is the silicon budget of a processor. Lower silicon budgets accommodate fewer uengines and require individual u-engines to target larger segments of the workload space which leads to lower energy efficiency benefits from customization, because there is more variation among the compute structures making up each cluster. Therefore, we also study how workload coverage and benefit can be maximized for a given silicon budget.
We study a broad general-purpose workload that includes 34 codes from 6 benchmark suites, identifying the most frequent functions, and clustering them based on two sets of instruction usage features (high-resolution and low-resolution) into 8, 16, 32, 64, 128 clusters respectively. We develop abstract metrics (coverage and weighted customization benefit) to evaluate the clusters. We show significant potential payoffs with four benefit models: 2-3x (square root model), 4-10x (linear model), 12-24x (quadratic model), and 22-26x (cubic model).
A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models
Authors: Zhang Xiaomei , Claerhout Sofie , Prat Aleix , Dobrolecki Lacey E. , Petrovic Ivana , Lai Qing , Landis Melissa D. , Wiechmann Lisa , Schiff Rachel , Giuliano Mario , Wong Helen , Fuqua Suzanne W. , Contreras Alejandro , Gutierrez Carolina , Huang Jian , Mao Sufeng , Pavlick Anne C. , Froehlich Amber M. , Wu Meng-Fen , Tsimelzon Anna , Hilsenbeck Susan G. , Chen Edward S. , Zuloaga Pavel , Shaw Chad A. , Rimawi Mothaffar F. , Perou Charles M. , Mills Gordon B. , Chang Jenny C. , Lewis Michael T. 
Published: June 2013

Abstract
Breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. To overcome these limitations, we propagated a cohort of human breast tumors grown in the epithelium-free mammary fat pad of severe combined immunodeficient (SCID)/Beige and nonobese diabetic (NOD)/SCID/IL-2γ-receptor null (NSG) mice under a series of transplant conditions. Both models yielded stably transplantable xenografts at comparably high rates (∼21% and ∼19%, respectively). Of the conditions tested, xenograft take rate was highest in the presence of a low-dose estradiol pellet. Overall, 32 stably transplantable xenograft lines were established, representing 25 unique patients. Most tumors yielding xenografts were “triple-negative” [estrogen receptor (ER)−progesterone receptor (PR)−HER2+; n = 19]. However, we established lines from 3 ER−PR−HER2+ tumors, one ER+PR−HER2−, one ER+PR+HER2−, and one “triple-positive” (ER+PR+HER2+) tumor. Serially passaged xenografts show biologic consistency with the tumor of origin, are phenotypically stable across multiple transplant generations at the histologic, transcriptomic, proteomic, and genomic levels, and show comparable treatment responses as those observed clinically. Xenografts representing 12 patients, including 2 ER+ lines, showed metastasis to the mouse lung. These models thus serve as a renewable, quality-controlled tissue resource for preclinical studies investigating treatment response and metastasis. Cancer Res; 73(15); 4885–97. ©2013 AACR.