bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multivariate linear regression of high‐dimensional fMRI data with multiple target variables
Authors: Valente Giancarlo , Castellanos Agustin Lage , Vanacore Gianluca , Formisano Elia 
Published: July 2013

AbstractMultivariate regression is increasingly used to study the relation between fMRI spatial activation patterns and experimental stimuli or behavioral ratings. With linear models, informative brain locations are identified by mapping the model coefficients. This is a central aspect in neuroimaging, as it provides the sought‐after link between the activity of neuronal populations and subject's perception, cognition or behavior. Here, we show that mapping of informative brain locations using multivariate linear regression (MLR) may lead to incorrect conclusions and interpretations. MLR algorithms for high dimensional data are designed to deal with targets (stimuli or behavioral ratings, in fMRI) separately, and the predictive map of a model integrates information deriving from both neural activity patterns and experimental design. Not accounting explicitly for the presence of other targets whose associated activity spatially overlaps with the one of interest may lead to predictive maps of troublesome interpretation. We propose a new model that can correctly identify the spatial patterns associated with a target while achieving good generalization. For each target, the training is based on an augmented dataset, which includes all remaining targets. The estimation on such datasets produces both maps and interaction coefficients, which are then used to generalize. The proposed formulation is independent of the regression algorithm employed. We validate this model on simulated fMRI data and on a publicly available dataset. Results indicate that our method achieves high spatial sensitivity and good generalization and that it helps disentangle specific neural effects from interaction with predictive maps associated with other targets.Hum Brain Mapp 35:2163–2177, 2014. ©2013 Wiley Periodicals, Inc.
The 12‐month prevalence and nature of adverse experiences resulting in emergency medical presentations associated with the use of synthetic cannabinoid products
Authors: Winstock Adam R. , Barratt Monica J. 
Published: July 2013

ObjectiveA wide range of synthetic cannabinoid products have recently become available through the Internet and shop fronts across the globe. Concerns about the consequences of their use have been prompted by increasing reports of emergency department presentations.MethodsAn anonymous global online survey was conducted using a research tool based on previous work carried out by the group. Data collection took place during a 4‐week period at the end of 2011.ResultsAmong 950 last‐year users, 23 (2.4%) reported having sought emergency medical treatment following the use of a synthetic cannabinoid product. The most common presentations were panic and anxiety, followed by paranoia and breathing difficulties. Recent users who reported seeking emergency medical treatment were significantly younger (median age 20 years, interquartile range 18–22) than those who did not report seeking treatment (median age 23 years, interquartile range 19–28; Mann–Whitney test, z = 2.89, p = 0.004).ConclusionsSynthetic cannabinoid use appears to be associated with a high prevalence of adverse experiences among users, especially younger users. Further research is required to determine whether particular compounds carry a higher risk of harm than others and to assess potential consequences of longer term use. Copyright © 2013 John Wiley & Sons, Ltd.
COMP‐Ang1 promotes chondrogenic and osteogenic differentiation of multipotent mesenchymal stem cells through the Ang1/Tie2 signaling pathway
Authors: Kim Sokho , Lee Jeong‐Chae , Cho Eui‐Sic , Kwon Jungkee 
Published: July 2013

ABSTRACTMesenchymal stem cells (MSCs) are pleiotrophic cells that differentiate to chondrocytes, osteoblasts, or adipocytes, as a result of crosstalk by specific signaling pathways including MAPK pathway. Recently cartilage oligomeric matrix protein angiopoietin1 (COMP‐Ang1), an Ang1 variant which is more potent than native Ang1 in phosphorylating Tie2 receptor was developed. The Ang1/Tie2 signaling system not only plays a pivotal role in vessel growth, remodeling, and maturation, but also protective and recruit effect on MSCs. Thus, the aim of the present study was to investigate the differentiate effect of Ang1/Tie2 signaling on MSCs in the presence of chondrogenic, osteogenic and adipogenic induction medium, and to determine the possible mechanisms. Our results clearly demonstrated that MSCs cultured in each induction medium with COMP‐Ang1 revealed strongly chondrogenic and osteogenic morphological change (3.5‐ and 2‐fold, respectively) as well as up‐regulate each gene, except for adipogenic differentiation. Accordingly, we found that phosphorylation of Tie2 expression lead to phosphorylation of p38 and AKT and then accelerating each differentiation of MSCs to chondrocytes and osteoblasts. Therefore, our findings suggest that COMP‐Ang1 present a portal to promote MSCs differentiation to chondrocytes and osteoblasts through Ang1/Tie2 signaling pathway and provide insights into novel therapies for bone diseases. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1920–1928, 2013
Antimicrobial lysozyme–chitosan coatings affect functional properties and shelf life of chicken eggs during storage
Authors: Yuceer Muhammed , Caner Cengiz 
Published: July 2013

AbstractBACKGROUNDThe interior quality, shell impact strength and functional characteristics of eggs coated with chitosan and lysozyme–chitosan combinations were evaluated for enhancing egg freshness during storage. A 10% (w/w) lysozyme solution was incorporated into 1% (w/w) chitosan film‐forming solution at ratios of 0, 10, 20 and 60% (w/w).RESULTSStorage time and coating had significant effects on Haugh unit, yolk index, weight loss, albumen pH, dry matter, relative whipping capacity (RWC) and albumen viscosity. Uncoated eggs had higher albumen pH and weight loss and lower albumen viscosity. All coated eggshells showed greater puncture strength than uncoated eggshells, resulting in extended shelf life. The 20 and 60% lysozyme–chitosan coatings were more effective in maintaining the internal quality of eggs (e.g. pH, dry matter and RWC). Attributes such as pH, dry matter and RWC were better after the 20% lysozyme–chitosan treatment than after the other treatments.ConclusionThe 10, 20 and 60% lysozyme–chitosan coatings, considered active packaging, showed promising attributes. They could be a viable alternative to existing techniques for maintaining the internal quality of fresh eggs during long‐term storage. Chitosan coatings also improved shell strength. This study also confirms that measurements of albumen quality (pH, dry matter, viscosity and RWC) are excellent indicators of egg freshness. © 2013 Society of Chemical Industry
Clinic significance of microRNA‐99a expression in human lung adenocarcinoma
Authors: Gu Wei , Fang Surong , Gao Lihua , Tan Yan , Yang Zhenhua 
Published: July 2013

AbstractBackgroundThe purpose of this study was to investigate the clinical significance of microRNA‐99a expression in lung adenocarcinoma.MethodsqRT‐PCR assay was performed to detect miR‐99a expression in lung adenocarcinoma cells or tissues. The correlations of miR‐99a expression with clinicopathological factors and prognosis of lung adenocarcinoma patients were analyzed. The effects of miR‐99a expression on growth and apoptosis of lung adenocarcinoma cell line and its potential target gene were determined by MTT, flow cytometry, luciferase reporter, and Western blot assays.ResultsThe relative miR‐99a expression in lung adenocarcinoma cells was significantly lower than that in normal lung bronchial epithelium cell line. Also, miR‐99a expression in lung adenocarcinoma tissues was significantly lower than that in corresponding nontumor tissues. Low miR‐99a expression was found to be closely correlated with advanced clinical stage and lymph node metastasis. Kaplan–Meier survival and Cox regression analyses showed that the status of miR‐99a expression was an independent prognosis factor for lung adenocarcinoma patients. Functional analyses showed that upregulation of miR‐99a could inhibit growth and induce apoptosis in lung adenocarcinoma cells by targeting mTOR.ConclusionLow MiR‐99a expression was a poor prognostic factor for patients with lung adenocarcinoma, and miR‐99a functions as a tumor suppressor by targeting mTOR. J. Surg. Oncol. 2013 108:248–255. © 2013 Wiley Periodicals, Inc.
Simultaneous separation of triterpenoid saponins and flavonoid glycosides from the roots of Glycyrrhiza uralensisFisch by pH‐zone‐refining counter‐current chromatography
Authors: Xu Jinfang , Luo Jianguang , Kong Lingyi 
Published: July 2013

Glycosides including triterpenoid saponins and flavonoid glycosides are the main constituents of Glycyrrhiza uralensis Fisch (licorice) and exhibit prominent pharmacological activities. However, conventional methods for the separation of glycosides always cause irreversible adsorption and unavoidable loss of sample due to their high hydrophilicities. The present paper describes a convenient method for the simultaneous separation of triterpenoid saponins and flavonoid glycosides from licorice by pH‐zone‐refining counter‐current chromatography. Ethyl acetate/n‐butanol/water (2:3:5, v/v) with 10 mM TFA in the upper organic stationary phase and 10 mM ammonia in the lower aqueous mobile phase was used as the biphasic solvent system. Three triterpenoid saponins and two flavonoid glycosides including licorice‐saponin A3 (63.3 mg), glycyrrhizic acid (342.2 mg), 3‐O‐[β‐d‐glucuronopyranosyl‐(1 → 2)‐β‐d‐galactopyranosyl]glycyrrhetic acid (56.0 mg), liquiritin apioside (232.6 mg), and liquiritin (386.5 mg) were successfully obtained from licorice ethanol extract (2 g) in one step. This method subtly takes advantage of the common acidic properties of triterpenoid saponins and flavonoid glycosides, and obviously is much more efficient and convenient than the previous methods. It is also the first time that the separation of acidic triterpenoid saponins by using pH‐zone‐refining counter‐current chromatography has been reported.
The Effect of Consumer Multifactorial Gender and Biological Sex on the Evaluation of Cross‐Gender Brand Extensions
Authors: Ulrich Isabelle 
Published: July 2013

ABSTRACTIntroducing cross‐gender brand extensions—masculine or feminine brands that extend to the opposite gender—is a growing trend on the marketplace, though not always a successful one. This research examines the effect of consumer multifactorial gender and biological sex on consumers’ evaluation of cross‐gender brand extensions. The influence of gender role attitudes is demonstrated: consumers with traditional gender attitudes are significantly more reluctant to accept these extensions than consumers with more liberal attitudes. Hence the extensions have a negative impact on the subsequent attitude of the former group toward the parent brand, contrary to their effect on more egalitarian consumers. No significant impact of the consumer's biological sex, gender identity, or sexual orientation is identified. The theoretical and managerial implications of these findings for the development of cross‐gender brand extensions are discussed.
Saturation recovery single‐shot acquisition (SASHA) for myocardial T1 mapping
Authors: Chow Kelvin , Flewitt Jacqueline A. , Green Jordin D. , Pagano Joseph J. , Friedrich Matthias G. , Thompson Richard B. 
Published: July 2013

PurposeTo validate a new saturation recovery single‐shot acquisition (SASHA) pulse sequence for T1 mapping and to compare SASHA T1 values in heart failure patients and healthy controls.TheoryThe SASHA sequence consists of 10 electrocardiogram‐triggered single‐shot balanced steady‐state free precession images in a breath‐hold. The first image is acquired without magnetization preparation and the remaining nine images follow saturation pulses with variable saturation recovery times.MethodsSASHA was validated through Bloch equation simulations, Monte Carlo simulations, and phantom experiments. Pre‐ and postcontrast myocardial and blood T1 values were measured in 29 healthy volunteers and 7 patients with heart failure.ResultsSASHA T1 values had excellent agreement (bias, 5 ± 5 ms) with spin echo experiments in phantoms with a wide range of physiologic T1 and T2 values and its accuracy was independent of flip angle, absolute T1, T2, and heart rate. The average baseline myocardial T1 in heart failure patients was higher than in healthy controls (1200 ± 32 vs. 1170 ± 9 ms, P < 0.05) at 1.5T, as was the calculated blood–tissue partition coefficient, λ, (0.42 ± 0.04 vs. 0.38 ± 0.02, P < 0.05), consistent with diffuse myocardial fibrosis.ConclusionsThe SASHA sequence is a simple and fast approach to in vivo T1 mapping with good accuracy in simulations and phantom experiments. Magn Reson Med 71:2082–2095, 2014. © 2013 Wiley Periodicals, Inc.
Impact of a drug utilization review program on high‐risk use of prescription controlled substances
Authors: Daubresse Matthew , Gleason Patrick P. , Peng Yi , Shah Nilay D. , Ritter Stephen T. , Alexander G. Caleb 
Published: July 2013

ABSTRACTBackgroundPrescription drug abuse has prompted considerable concern. We evaluated a retrospective drug utilization review program to reduce controlled substance use among individuals with high‐risk utilization.MethodsWe analyzed pharmacy claims from a large pharmaceutical benefits manager. For each eligible member, we calculated a controlled substance score based on the number and type of claims, prescribers and pharmacies, and utilization patterns over three months. Two state health plans sent controlled substance letters to prescribers of members meeting or exceeding a plan‐ and pre‐specified controlled substance score. Two different state health plans did not send such letters. We used a difference‐in‐difference design and generalized estimating equations to quantify the impact of the program on the mean difference in reduction of the controlled substance score over six months.ResultsEligible members in the intervention and comparison states had similar baseline mean controlled substance scores (19.0 vs. 18.6, p = 0.36). Adjusting for individuals' age, sex and pharmacy risk group score, reductions in the mean controlled substance score were greater in the intervention than comparison cohort (5.67 vs. 4.31, p = 0.01), corresponding with a 34.0% reduction in the intervention cohort compared to a 25.5% reduction in the comparison cohort. Changes were driven primarily by reductions in the number of controlled substance claims filled (30.5% vs. 23.1%, p = 0.01), as well as by a non‐statistically significant trend towards reductions in the number of prescribers and pharmacies used (26.9% vs. 20.1%, p = 0.07).ConclusionsRetrospective drug utilization review programs may reduce controlled substance scores and claims among individuals with patterns suggesting high‐risk utilization. Copyright © 2013 John Wiley & Sons, Ltd.
Preferences for and experiences of family involvement in cancer treatment decision‐making: patient–caregiver dyads study
Authors: Shin Dong Wook , Cho Juhee , Roter Debra L. , Kim So Young , Sohn Sang Kyun , Yoon Man‐Soo , Kim Young‐Woo , Cho BeLong , Park Jong‐Hyock 
Published: July 2013

AbstractBackgroundDespite the important role that family caregivers play in providing emotional and practical support to cancer patients, relatively little is known about the family caregiver's role in treatment decision‐making (TDM). We sought to investigate patients' and family caregivers' preferences for and experiences of family involvement in TDM and factors associated with preference concordance.MethodA national survey was performed with 990 patient–caregiver dyads (participation rate:76.2%). Questions examining preferences for and experiences of family involvement in TDM were administered independently to patients and family caregivers. Concordance was calculated with weighted kappa. Logistic regression analyses were used to identify predictors of patients' and caregivers' preferences for family involvement in TDM and concordance between them.ResultsFew patients or family caregivers expressed a preference for unilateral decision‐making; however, there was considerable variation and poor agreement within dyads in regard to whether the patient or family caregivers should take the lead in decision‐making with input from the other (weighted kappa between respondents for TDM preferences and experiences = 0.10 and κ = 0.18, respectively). Greater TDM preference concordance was associated with higher patient education, whereas lower levels of concordance were evident for younger patients, less educated caregivers, adult child patient dyads (as opposed to a spouse–patient dyads) and problematic family communication about cancer.ConclusionsMost patients and family caregivers valued and expected family involvement in TDM. However, there is little explicit agreement in regard to which party in the dyad should take decisional leadership and who should play a supporting role. Copyright © 2013 John Wiley & Sons, Ltd.
The effect of including a ‘psychooncological statement’ in the discharge summary on patient‐physician communication: a randomized controlled trial
Authors: Book Katrin , Dinkel Andreas , Henrich Gerhard , Stuhr Claudia , Peuker Mareike , Härtl Kristin , Brähler Elmar , Herschbach Peter 
Published: July 2013

AbstractObjectiveThe objective of this study is to determine whether the inclusion of a ‘psychooncological statement’ (PO‐statement) in the discharge summary enhances patient‐physician communication about psychosocial issues across the inpatient and outpatient sector.MethodsA total of 1416 cancer patients were randomly assigned to the intervention (with PO‐statement in the discharge summary) or control group (discharge summary without PO‐statement). Shortly before discharge from the hospital (T1), patients from the intervention group were screened for psychosocial distress. Based on the electronic clinical documentation system, screening results were subsequently integrated into the discharge summary, which automatically generated a PO‐statement. To determine the effect of the PO‐statement, patients as well as their primary care physicians (n = 596) were asked during follow‐up care (T2) whether psychosocial distress was discussed during the last consultation.ResultsIncluding a PO‐statement in the discharge summary did not result in more frequent discussions about psychosocial issues compared with the control group from the patients' and physicians' perspectives. Instead, discussions about psychosocial well‐being were significantly associated with women of the patient (p = <0.001) and the physician (p = 0.011), medical discipline (gynecologists; p = 0.002), cancer diagnosis (gynecological cancer; p = 0.002), metastases (p = <0.001), professional training of patients (none, p = 0.026), and psychosocial qualification of physicians (p = 0.018).ConclusionWritten information on psychosocial distress in the discharge summary alone does not affect communication. Copyright © 2013 John Wiley & Sons, Ltd.
Comparison of the Crystals Obtained by Precipitation of CL‐20 with Different Chemical Purity
Authors: Maksimowski Paweł , Skupiński Wincenty , Szczygielska Joanna 
Published: July 2013

AbstractThe precipitation of CL‐20 with different chemical purity is presented herein. Studies have shown that the first crystallization of the crude CL‐20 does not allow achieving the expected polymorphic purity and slightly increases chemical purity. Further precipitation processes result in gradual increase of the chemical purity about 1–2 % and in the improvement of the properties of crystals, i.e. density, polymorphic purity, and sensitivity to friction. This paper attempts a preliminary purification of the crude CL‐20 with columns filled with activated charcoal. A material of high purity, obtained by this process, was used in the process of precipitation. As a result of the crystallization a sample of CL‐20 was obtained with high chemical purity of 99.5 % and significantly reduced sensitivity to friction (128 N) and to impact (4 J). Additionally, samples of CL‐20, recovered from the filtrate after crystallization with a chemical purity of about 88 %, were purified on columns filled with activated charcoal. In this process a significant amount of impurities was removed and the purity was increased to 96 %.
Efficient certificateless encryption withstanding attacks from malicious KGC without using random oracles
Authors: Yang Wenjie , Zhang Futai , Shen Limin 
Published: July 2013

ABSTRACTAs the key generation center (KGC) in a certificateless cryptosystem is no longer fully trusted, for practical applications, a secure certificateless encryption (CLE) scheme should withstand malicious KGC attacks. In this paper, we investigate practical CLE schemes withstanding attacks from a malicious KGC without resorting to random oracles. At first, we show the insecurity of the CLE scheme (ZW scheme) presented by Zhang and Wang. Although ZW scheme was proved to be chosen ciphertext secure without using random oracles, we find that it cannot resist attacks from a malicious KGC. We show an attack that demonstrates a malicious KGC can easily decrypt a target ciphertext using chosen ciphertext attack. After that, we introduce a new efficient CLE scheme. We prove its CCA2 security without using random oracles. Our new scheme not only gets rid of the security drawbacks of ZW scheme but also keeps its most distinctive feature of a short public key length. The formal security proofs of the new scheme are presented without using random oracles assuming the hardness of the decisional truncated q‐augmented bilinear Diffie‐Hellman exponent (q‐ABDHE) problem and the hardness of the decisional bilinear Diffie–Hellman problem. Copyright © 2013 John Wiley & Sons, Ltd.
An improved Pareto distribution for modelling the fault data of open source software
Authors: Luan Shao‐Pu , Huang Chin‐Yu 
Published: July 2013

SUMMARYIn the modern society, software plays a very important role in many application systems. Consequently, the main goal of project managers and software engineers is to deliver reliable software within very limited resource, time and budget during the software development life cycle. Presently, it is widely recognized that open source software (OSS) has developed as a new (and novel) form of both personal and aggregation production. In the past, some research has shown that the traditional Pareto distribution (PD) and the Weibull distribution models can be used to describe the distribution of software faults of OSS. However, there could be a negative value for the cumulative probability of the traditional PD model in some cases. In this paper, based on our past studies, a modified Pareto‐based distribution model, called the single‐change‐point 2‐parameter generalized PD (SCP‐2GPD) model is proposed. The method of choosing an appropriate change‐point is presented and illustrated. Some mathematical properties of the proposed model are also discussed. Experiments are conducted using several real OSS data, and evaluation results show that our proposed SCP‐2GPD model depicts the real‐life situation of the software development life cycle more faithfully and accurately. Copyright © 2013 John Wiley & Sons, Ltd.