bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the potential mechanisms of Litsea cubeba essential oil for anti-melanoma through experimental validation, network pharmacology, and molecular docking analysis
Authors: Yang Xiao-Qin , Liu Meng-Zhe , Han Kang-Jia , Zhao Ping , Li Liuzemu , Liu Si-Si , Yang Bo , Liu Ru-Kuan 
Published: July 2024

Abstract

Objectives
Melanoma remains a challenge due to the lack of effective and low-toxicity treatments. Litsea cubeba essential oil (LEO), known for its tyrosinase inhibitory activity, has shown promise as an anti-melanoma compound, although robust scientific evidence is lacking.

Methods
We conducted GC-MS analysis to identify the major components of LEO and screened for effective components were further evaluated on A375 and HaCaT cells using the CCK-8 assay. Network pharmacology was employed to predict potential targets using PharmMapper and SwissTarget Prediction databases, with melanoma-related targets sourced from the GeneCards database. Protein–protein interaction (PPI) network was created using STRING and Cytoscape. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed through the DAVI database. Additionally, we constructed a natural product-main components-core targets-pathways-disease (NMCPD) network in Cytoscape and conducted molecular docking using PyMOL and Autodock Vina.

Results
GC-MS analysis revealed neral (cis-citral) and geranial (trans-citral) as the primary active components of LEO. Cell assays demonstrated that a citral mixture, in combination with LEO, effectively inhibited A375 cell growth with IC50 values of 35.94 ± 1.23 μM and 12.00 ± 0.96 μg/mL, while exhibiting minimal toxicity to HaCaT cells with IC50 values of 67.72 ± 2.96 μM and 22.32 ± 2.53 μg/mL. Screening identified10 hub targets among 190 common targets between drug and disease-related targets. KEGG pathway enrichment analysis suggested therapeutic effects of citral on melanoma by modulating signaling pathways. Molecular docking revealed strong binding affinity of neral and geranial with RXRA and ESR1, suggesting that citral, the principal LEO component, regulates multiple pathways for potential melanoma therapy.

Conclusions
These findings support the potential utility of LEO as a treatment for melanoma and highlight the importance of exploring tyrosinase inhibitors for the development of novel anti-melanoma drugs.
Perspektiven auf widerständisches Argumentieren im ‚Dritten Reich‘
Authors: Markewitz Friedrich 
Published: July 2024

AbstractResistance in the ‚Third Reich‘ was a mostly solitary and thus lonely struggle not only against the National Socialist regime, but also for being heard by the silent majority society. In addition to the various communicative practices of warning, admonishing, or calls to action, argumentation also played an important role. The task was not only to convince members of the majority society of the righteousness of their resistance goals and perspectives, but also to agree on goals and perspectives within the various resistance groups and in the exchange between these groups. This dual role of argumentation as a practice that is constitutive of both the group as well as the group’s identity makes this communicative practice an important phenomenon in capturing communicative conditions, circumstances, and paradigms of resistance to National Socialism. In this paper, these functional contexts are examined and the way in which arguments were used both to persuade members of the integrated society and to negotiate consensual principles and goals within resistance groups are discussed.
Herausforderung Rezeptionsanalyse: zur Wahrnehmung von Wissenschaftskommunikation während der Coronapandemie
Authors: Ruge Sarah-Juliane , Jaki Sylvia 
Published: July 2024

Abstract
More than ever before, the COVID-19 pandemic has highlighted the importance and challenges of high-quality science communication. In various phases of the pandemic, the public voiced discontent about the way scientific results were communicated. This article is anchored in the field of media linguistic reception research. Its aim is less to shed light on the quality of science communication itself than to pursue the question which methods in reception research are most suitable for illuminating how recipients perceived the pandemic. To this end, we compare the results of a survey with the analysis of comments from the comment sections of four YouTube videos. The results imply that, for this specific case, the analysis of social media comments is more suitable as an addition to the survey rather than constituting an alternative because surveys can elicit targeted responses whereas comment sections contain a whole spectrum of topics addressed. The study also comes to the conclusion that, in addition to target-group-oriented, comprehensible communication, it is above all important to raise awareness for the kind of processes that shape an academic’s work.
Kokybinis žvilgsnis į traumą: psichikos sveikatos specialistų terapinio darbo su trauminius išgyvenimus patyrusiais suaugusiais klientais ypatumai
Authors: Šaltenytė Ieva , Kaluževičiūtė Greta 
Published: July 2024

Most people experience potentially traumatic events at least once throughout their lifetimes. Even if this event does not lead toward posttraumatic stress disorders, mental health can be affected significantly. The difficulties caused by traumatic experiences are often addressed in psychotherapy, therefore understanding the specifics of trauma work and the challenges faced both by clients with traumatic experiences and by therapists providing support is important. This study explores and describes the views and experiences of psychotherapy practitioners working in the field of trauma with adult clients. Thirty mental health professionals participated in the study. Thematic analysis of open-ended survey responses revealed three main themes: 1) the vulnerability of the therapeutic process, 2) experiencing trauma work, and ٣) helping yourself to help others. Trauma work is described as a slow process that calls for patience, high-level care, and attentiveness in addressing clients’ pain. Clients often mistrust others and therapists put a great effort into establishing trusted relationships with them. Therapists experience a high emotional load, often feel hopeless, but also find their work rewarding and meaningful when clients make progress. Most therapists emphasize the importance of helping yourself: studying and preparing for trauma work, understanding personal traumatic experiences, and taking excellent care of one’s psychological well-being. The study revealed the subjective complexity of therapeutic trauma work. The insights can be valuable for the development and/or review of therapy training programs, supervisors, and therapists looking for information about their professional challenges in working with trauma.
Szeniorok a felsőoktatásban
Authors: Kerülő Judit 
Published: July 2024

A magyar felsőoktatási törvény az intézmények oktatási és kutatási alapfeladata
mellett azt is megfogalmazza, hogy az alaptevékenységből származó szellemi
értékek közösségi célú megismertetésével hozzá kell járulniuk térségük
társadalmi és gazdasági életéhez is.
A várható élettartam növekedésével világszerte megnőtt az idősek népességbeli
aránya. Úgy az egyén, mint a közösség, a társadalom számára fontos, hogy ez a
korosztály milyen életminőségben éli az életét. Tanulmányomban a felsőoktatási
intézmények szenior oktatásban vállalt feladatának hazai gyakorlatát mutatom be.
Ismertetem és elemzem az intézményi specialitásokból fakadó jellemzőket. A
szerző maga is több oldalról érintett a témában, egyrészt ehhez a korcsoporthoz
tartozik, másrészt négy éve aktív oktatója és kurzusvezetője a képzéseknek.
Szeniorokkal készült interjúk alapján vizsgálom és elemzem a résztvevők tanulási
motivációját, kurzusokkal kapcsolatos elvárásait, tanulási sajátosságait, az
aktivitást segítő és akadályozó tényezőket. Továbbá írok a jelenléti és a 2020
óta egyre elterjedtebb digitális oktatás tapasztalatairól is.
Sensitivity and specificity of International Classification of Diseases algorithms (ICD-9 and ICD-10) used to identify opioid-related overdose cases: A systematic review and an example of estimation using Bayesian latent class models in the absence of gold standards
Authors: Mbutiwi Fiston Ikwa Ndol , Yapo Ayekoe Patrick Junior , Toirambe Serge Esako , Rees Erin , Plouffe Rebecca , Carabin Hélène 
Published: July 2024

Abstract
Objectives
This study aimed to summarize validity estimates of International Classification of Diseases (ICD) codes in identifying opioid overdose (OOD) among patient data from emergency rooms, emergency medical services, inpatient, outpatient, administrative, medical claims, and mortality, and estimate the sensitivity and specificity of the algorithms in the absence of a perfect reference standard.

Methods
We systematically reviewed studies published before December 8, 2023, and identified with Medline and Embase. Studies reporting sufficient details to recreate a 2 × 2 table comparing the ICD algorithms to a reference standard in diagnosing OOD-related events were included. We used Bayesian latent class models (BLCM) to estimate the posterior sensitivity and specificity distributions of five ICD-10 algorithms and of the imperfect coroner’s report review (CRR) in detecting prescription opioid–related deaths (POD) using one included study.

Results
Of a total of 1990 studies reviewed, three were included. The reported sensitivity estimates of ICD algorithms for OOD were low (range from 25.0% to 56.8%) for ICD-9 in diagnosing non-fatal OOD-related events and moderate (72% to 89%) for ICD-10 in diagnosing POD. The last included study used ICD-9 for non-fatal and fatal and ICD-10 for fatal OOD-related events and showed high sensitivity (i.e. above 97%). The specificity estimates of ICD algorithms were good to excellent in the three included studies. The misclassification-adjusted ICD-10 algorithm sensitivity estimates for POD from BLCM were consistently higher than reported sensitivity estimates that assumed CRR was perfect.

Conclusion
Evidence on the performance of ICD algorithms in detecting OOD events is scarce, and the absence of bias correction for imperfect tests leads to an underestimation of the sensitivity of ICD code estimates.
Current state of the problem of assessing the quality of life in patients with cervical cancer after organ-preserving treatment
Authors: Dil O. S. , Chernyshova A. L. , Balatskaya L. N. , Truschuk Yu. M. , Chernyakov A. A. 
Published: July 2024

An indicator of the effectiveness of treatment of cancer patients, in addition to oncological results, is also the preservation of their quality of life. Quality of life assessment is a modern research method that allows identifying even minor changes in any spheres of human activity in order to comprehensively determine the effectiveness of treatment. The quality of life of cancer patients is a priority and promising area of modern medicine.The article presents information about the current state of the problem of quality of life of patients with cervical cancer after organ-preserving treatment. The results of a number of foreign studies published on this topic are presented. In addition, the results of a prospective study conducted in the Department of Gynecology of the Tomsk Oncology Research Institute are presented. In conclusion, the need for additional study of reproductive results and determining which factors need to be further evaluated, speaking of a comprehensive assessment, is shown.
Modeling the impact of using trastuzumab deruxtecan in patients with breast cancer on reducing cancer mortality in Russia
Authors: Avxentyev N. A. , Makarova Yu. V. , Makarov A. S. 
Published: July 2024

Background. Reducing malignant mortality to 185 cases per 100,000 by 2030 is one of goals of the state program “Healthcare development” in Russia.Aim. To assess potential impact of using trastuzumab deruxtecan in patients with breast cancer on reducing cancer mortality.Materials and methods. Three indications of trastuzumab deruxtecan were considered: adult patients with HER2-positive unresectable or metastatic breast cancer that were previously treated with trastuzumab and a taxane in the advanced or metastatic setting (referred as “Second line”); adult patients with HER2-positive unresectable or metastatic breast cancer who previously received at least two lines of therapy in the metastatic setting including trastuzumab emtansine (referred as “Third line”); adult patients with HER2-low metastatic breast cancer who had received one or two previous lines of chemotherapy (referred as “HER2-low metastatic breast cancer”). The set of comparators for each clinical situation was formed based on the clinical guidelines and clinical trials of trastuzumab deruxtecan. Overall survival and treatment duration were modelled on the clinical trials basis. The model was used to estimate number of lives saved in case of transitioning all eligible patients to trastuzumab deruxtecan within a three-year horizon.Results. Up to 3,609 patients p. a. in the “Second line” situation, 1,300 patients p. a. in the “Third line” situation and 2,260 patients p. a. in the “HER2-low breast cancer” situation can initiate trastuzumab deruxtecan treatment. In that case mortality from neoplasms could be reduced by 1,461 deaths in case of “Second line”, by 427 deaths in case of “Third line” and by 801 deaths in case of “HER2-low metastatic breast cancer” over three years. Reduction in mortality will contribute to achieving the target mortality rate from neoplasms of 21.61–24.81 %, 4.31–12.57 % and 5.91–20.89 %, respectively.Conclusion. Using trastuzumab deruxtecan for breast cancer treatment in different clinical situations leads to quantitate reduction in cancer mortality in Russia.
Kościół Polskokatolicki w Rzeczypospolitej Polskiej. Perspektywa historyczna, teologiczna i ekumeniczna
Authors: Rabczyński Paweł 
Published: July 2024

Celem niniejszego artykułu jest syntetyczne przedstawienie Kościoła Polskokatolickiego w RP z perspektywy historycznej, teologicznej i ekumenicznej. Podstawowym źródłem opracowania są studia historyczne i teologiczne dotyczące Kościoła Polskokatolickiego oraz opublikowane materiały z prac zespołów rzymskokatolickiego i polskokatolickiego, będące owocem prowadzonego dialogu ekumenicznego. Eksplikacji tytułowej problematyki posłuży metoda historyczno-syntetyczna. We współczesnym świecie, naznaczonym antagonizmami i podziałami, szczególnie aktualne jest wezwanie do pojednania i widzialnej jedności wszystkich wyznawców Jezusa Chrystusa. Działania na rzecz jedności Kościołów i Wspólnot kościelnych wpływają na wiarygodność chrześcijaństwa. Od 1998 r. Kościół Polskokatolicki prowadzi oficjalny dialog ekumeniczny z Kościołem Rzymskokatolickim w Polsce. Owocem dialogu jest porzucenie wzajemnych uprzedzeń, lepsze poznanie się, wyjaśnienie różnic doktrynalnych i prawno-dyscyplinarnych. Kościół Polskokatolicki wyłonił się z diecezji misyjnej Polskiego Narodowego Kościoła Katolickiego w Stanach Zjednoczonych Ameryki Północnej i Kanadzie (PNKK) w 1951 r. Jest samodzielny i niezależny organizacyjnie. Pozostaje w jedności wiary i moralności z macierzystym PNKK. Posiada ustrój synodalno-episkopalny. Kościół Polskokatolicki jest członkiem Unii Utrechckiej Kościołów Starokatolickich, Światowej Rady Kościołów, Konferencji Kościołów Europejskich oraz członkiem-współzałożycielem Polskiej Rady Ekumenicznej.
Rôle de l’Identification chez l’Adolescent Exposé à la Violence Conjugale au Cameroun
Authors: Tabue Defo Fabrice Rocard , Kameni Ngaleu Achille Garance 
Published: July 2024

La violence conjugale au Cameroun est un fléau qui va grandissant mais, curieusement, vécue dans nombreuse famille comme une banalité. Malheureusement, cette violence entre les parents (verbale, physique, psychologique, économique et spirituelle) se pratique en présence des adolescents. Cette présence des adolescents va créer chez eux de la souffrance psychologique. Ladite souffrance va être par la suite évacuée par l’appareil psychique. C’est dans cette mouvance que notre étude a pour objectif de comprendre le processus d’évacuation de la souffrance psychique chez l’adolescent exposé à la violence conjugale. La méthode clinique a été utilisée comme méthode de recherche. Les entretiens ont été faits auprès de trois adolescents fréquemment exposés à la violence conjugale au Cameroun. Les données recueillies auprès des sujets ont été analysées à travers l’analyse thématique de contenu suivant l’approche psychanalytique. Il ressort des résultats à travers les entretiens semi-directifs que l’adolescents camerounais exposé à la violence conjugale est atteint sur son psychisme. Cependant, ces adolescents face à cette adversité, mobilisent de l’énergie psychique en se basant sur l’identification aux pairs non exposés à la violence conjugale pour évacuer la souffrance psychique. Le fait pour l’adolescent de s’identifier aux pairs non exposés, va restaurer l’équilibre psychique.

Marital violence in Cameroon is a growing scourge but, curiously, experienced in many families as a banality. Unfortunately, this violence between parents (verbal, physical, psychological, economic and spiritual) is practiced in the presence of adolescents. This presence of adolescents will create psychological suffering for them. This suffering will subsequently be evacuated by the psychic. The objectives of this study is to understand the process of evacuating psychological suffering in adolescents exposed to marital violence. The clinical method was used as a research method. The interviews were carried out with three adolescents frequently exposed to marital violence in Cameroon. The data collected from the subjects were analyzed through thematic content analysis following the psychoanalytic approach. It appears from results through interviews semi-structured that Cameroonian adolescents exposed to marital violence are affected on their psychic. However, these adolescents, faced with this adversity, mobilized psychic energy based on identification with peers not exposed to marital violence to relieve psychological suffering. The fact that the adolescent identifies with unexposed peers will restore psychological balance.
Monitoring And Automatic Control Systems In The Light Trap Of Onion Leaf Pests Based Internet Of Things
Authors: Enriko I Ketut Agung , Kuswanda Kuswanda , Kurnianto Danny , Gustiyana Fikri Nizar 
Published: July 2024

Tanaman bawang merah menjadi salah satu mata pencaharian petani yang memiliki nilai jual yang tinggi dari hasil panennya. Namun, kebanyakan petani masih mengendalikan hama tanaman bawang merah dengan penyemprotan pestisida secara berlebihan dan dikhawatirkan tanaman bawang merah mengalami kelebihan residu. Pengendalian fisik sudah diupayakan dengan memasang light trap di perkebunan tetapi pengoperasianya masih manual sehingga tidak efisien terhadap waktu kerja petani serta rawan terjadi pemborosan energi listrik akibat kelalaian. Pada penelitian ini light trap tersebut akan di optimasi dengan menerapkan sistem monitoring dan kontrol lampu otomatis supaya petani bisa mengetahui estimasi biaya dari listrik yang dipakai serta listrik yang dipakai bisa sesuai dengan kebutuhan. LYNX32 BOARD LoRa berperan penting sebagai pengolah data yang terhubung dengan sensor LDR agar lampu bisa menyala secara otomatis, sensor PZEM-004T agar bisa memantau tegangan dan arus yang ada pada light trap dan dikirimkan melalui komunikasi LoRa. Pada penelitian ini kontrol otomatis dapat beroperasi berdasarkan intensitas cahaya, LoRa dapat mengirimkan data sampa jarak 250 meter dengan kondisi LoS. Sensor PZEM-004T memiliki akurasi yang bagus untuk tegangan dengan kesalahan 0.08% sedangkan untuk presentase kesalahan arus dan daya cukup tinggi yaitu 13.26% dan 5%.
United States Federal Policies Contributing to Health and Health Care Inequities in Puerto Rico
Authors: McSorley Anna-Michelle Marie , Rivera-González Alexandra C. , Mercado Damaris Lopez , Pagán José A. , Purtle Jonathan , Ortega Alexander N. 
Published: July 2024

Puerto Rico, a territory of the United States since 1898, has recently experienced an increasing frequency and intensity of natural disasters and public health emergencies. In 2022, Hurricane Fiona became the latest storm to attract media attention and cast a light on Puerto Rico’s deteriorating conditions, including infrastructural failings, health care provider shortages, and high levels of chronic illness. Although recent events have been uniquely devastating, decades of inequitable US federal policy practices have fueled the persistence of health inequities in the territory. Here we demonstrate how existing health and health care inequities in Puerto Rico have been exacerbated by compounding disasters but are rooted in the differential treatment of the territory under US federal policies. Specifically, we focus on the unequal US Federal Emergency Management Agency response to disasters in the territory, the lack of parity in federal Medicaid funding for Puerto Rico, and Puerto Rico’s limited political power as a territory of the United States. We also provide empirically supported policy recommendations aimed at reducing health and health care inequities in the often-forgotten US territory of Puerto Rico. ( Am J Public Health. 2024;114(S6):S478–S484. https://doi.org/10.2105/AJPH.2024.307585 ) [Formula: see text]
Implementation of Sharia Marketing to increase Millennial Interest in Financing: Evidence on BSI Dharmawangsa Branch Office
Authors: Yudha Ana Toni Roby Candra , Zulfiah Hilya , Atho'illah Akh. Yunan 
Published: July 2024

Bank Syariah Indonesia (BSI provides BSI Griya Simuda financing that has been tailored to the needs and abilities of the millennial generation. Marketing carried out in Islamic financing must be in accordance with the provisions of Islamic sharia. So this research aims to find out the implementation and evaluation of online and offline sharia marketing in increasing millennial interest in financing of BSI Griya Simuda.. Research Methods: This research approach uses a qualitative approach, by analysing data obtained from interviews, observation and documentation. Results: The results of this research show that in marketing BSI Griya Simuda financing in managerial and operational had carried out online and offline have applied the principles of sharia marketing and the characteristics of sharia marketing, namely theistic (rabbaniyyah), ethical (akhlaqiyyah), realistic (al-waqiyyah) and humanitis (al-insaniyah). Conclusion:Then the results of the evaluation found that the millennial generation's interest in BSI Griya Simuda financing is good, but in marketing there are obstacles and challenges, namely there are still efforts to compare conventional banks with Islamic banks in terms of prices and products.