bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lamotrigine use in patients with binge eating and purging, significant affect dysregulation, and poor impulse control
Authors: Trunko Mary Ellen , Schwartz Terry A. , Marzola Enrica , Klein Angela S. , Kaye Walter H. 
Published: December 2013

ABSTRACTObjectiveSome patients with symptoms of binge eating and purging are successfully treated with specific serotonin reuptake inhibitors (SSRIs), but others experience only partial or no benefit. Significant affect dysregulation and poor impulse control may be characteristics that limit responsiveness.MethodWe report on the treatment of five patients with bulimia nervosa (BN), anorexia nervosa—binge/purge type (AN‐B/P) or eating disorder not otherwise specified (EDNOS), using the anticonvulsant lamotrigine after inadequate response to SSRIs.ResultsFollowing addition of lamotrigine to an antidepressant in four cases, and switch from an antidepressant to lamotrigine in one case, patients experienced substantial improvement in mood reactivity and instability, impulsive drives and behaviors, and eating‐disordered symptoms.DiscussionThese findings raise the possibility that lamotrigine, either as monotherapy or as an augmenting agent to antidepressants, may be useful in patients who binge eat and purge, and have significant affect dysregulation with poor impulse control. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:329–334)
Air‐Stable and Volatile Bis(pyridylalkenolato)germanium(II), ‐tin(II), and ‐lead(II) Complexes
Authors: Heidemann Tim , Mathur Sanjay 
Published: December 2013

AbstractHomoleptic germanium(II), tin(II), and lead(II) complexes of the general formula M(2‐PyCHCOCF3)2 (M = Ge, Sn, Pb; Py = pyridine) were synthesized by treating the corresponding silyl amides [M{N(SiMe3)2}2] with two equivalents of a 3,3,3‐trifluoro‐1‐(2‐pyridyl)prop‐1‐en‐2‐ol (2‐PyCHCOHCF3) ligand. Single‐crystal X‐ray diffraction revealed the bidentate chelation of 2‐PyCHCOHCF3, which imposes a distorted trigonal bipyramidal geometry for all three molecular structures; this distortion is highest for the lead compound, probably as a result of the high s character of the lone pair of electrons present on the metal centers. The monomeric nature of the compounds in solution was confirmed by multinuclear NMR spectroscopy, whereas a polymeric structure is observed for the lead complex in the solid state.
Tris(pyrazolyl)phosphine Oxide and Tris(triazolyl)phosphine Oxide Scorpion Ligands
Authors: Tazelaar Cornelis G. J. , Lyaskovskyy Volodymyr , van Doorn Ilana M. , Schaapkens Xander , Lutz Martin , Ehlers Andreas W. , Slootweg J. Chris , Lammertsma Koop 
Published: December 2013

AbstractDFT calculations were performed on copper(I) complexes of neutral scorpion ligands based on either pyrazolyl (Pz) or triazolyl (Tz) rings with both methane and phosphine oxide apexes, that is, HC(Pz)3, OP(Pz)3, HC(Tz)3, and OP(Tz)3. The analyses reveal that all four ligands have similar donor properties and that their differences are easily compensated by the proper choice of substituents. This computational study strongly suggests that the readily synthesizable neutral phosphine oxide capped scorpion ligands should have broad applicability. Experimentally, the two OP‐capped ligands act differently on copper(I) complexation. With OP(Tz)3, a crystallographically characterized dimeric tris(triazolyl)phosphine oxide based copper(I) complex was obtained, whereas instead a monomer was reported for OP(Pz)3.
Complex regional pain syndrome type I of the knee: A systematic literature review
Authors: van Bussel C.M. , Stronks D.L. , Huygen F.J.P.M. 
Published: December 2013

AbstractIn our Center for Pain Medicine, a group of patients reported to have symptoms possibly attributable to complex regional pain syndrome (CRPS) of only the knee(s). Therefore, this study aimed to investigate whether the literature reports on patients with CRPS type I in the knee(s) alone and, if so, to summarize the reported diagnostics, aetiology and treatment strategies of CRPS of the knee(s). Medline, Embase, Cochrane Library, PubMed and Web of Science were searched for articles focusing on a painful disorder of the knee, most likely CRPS type I. Screening on title and abstract was followed by full‐text reading and searching of reference lists to determine the final set of relevant articles. Of the 513 articles identified, 31 met the inclusion criteria. These articles reported on a total of 368 patients diagnosed with CRPS of the knee(s) based on the diagnostic criteria used at the time of publication. Knee surgery, especially arthroscopic surgery, was the most common inciting event in developing CRPS of the knee(s). Various treatment strategies were applied with variable outcomes. In conclusion, the scientific literature does report cases of CRPS type I of only the knee(s). This applies when using the diagnostic criteria prevailing at the time of publication and, obviously for a smaller number of cases, also when using the current Budapest criteria set. Arthroscopic knee surgery is described multiple times as the inciting event. We recommend to include CRPS of the knee in future research on the aetiological mechanisms of and optimal treatment for CRPS.
Use of the mouse ear vesicant model to evaluate the effectiveness of ebselen as a countermeasure to the nitrogen mustard mechlorethamine
Authors: Lulla Anju , Reznik Sandra , Trombetta Louis , Billack Blase 
Published: December 2013

ABSTRACTPrevious studies in this and other laboratories have demonstrated that ebselen (EB‐1), an organoselenium compound, spares cells from mechlorethamine (HN2) toxicity in vitro. In the present study, the hypothesis that EB‐1 will reduce dermal toxicity of HN2 in vivo is put forward and found to have merit. Using the mouse ear vesicant model (MEVM), HN2, applied topically, showed a dose‐dependent effect upon ear swelling and thickness 24 h after treatment; whereas tissue injury consistent with vesication was observed at the higher test doses of HN2 (≥ 0.250 µmol per ear). To examine HN2 countermeasure activity using the MEVM, either hydrocortisone (HC), as a positive control, or EB‐1, the test countermeasure, was administered as three topical treatments 15 min, 4 and 8 h after HN2 exposure. Using this approach, both HC and EB‐1 were found to reduce tissue swelling associated with HN2 toxicity 24 h after exposure to the vesicant. Taken together, these data demonstrate for the first time the effectiveness of EB‐1 as a vesicant countermeasure in a relevant in vivo model. Copyright © 2013 John Wiley & Sons, Ltd.
CARS based label‐free assay for assessment of drugs by monitoring lipid droplets in tumour cells
Authors: Steuwe Christian , Patel Imran I. , Ul‐Hasan Mahmud , Schreiner Alexander , Boren Joan , Brindle Kevin M. , Reichelt Stefanie , Mahajan Sumeet 
Published: December 2013

AbstractCoherent anti‐Stokes Raman scattering (CARS) is becoming an established tool for label‐free multi‐photon imaging based on molecule specific vibrations in the sample. The technique has proven to be particularly useful for imaging lipids, which are abundant in cells and tissues, including cytoplasmic lipid droplets (LD), which are recognized as dynamic organelles involved in many cellular functions. The increase in the number of lipid droplets in cells undergoing cell proliferation is a common feature in many neoplastic processes [1] and an increase in LD number also appears to be an early marker of drug‐induced cell stress and subsequent apoptosis [3]. In this paper, a CARS‐based label‐free method is presented to monitor the increase in LD content in HCT116 colon tumour cells treated with the chemotherapeutic drugs Etoposide, Camptothecin and the protein kinase inhibitor Staurosporine. Using CARS, LDs can easily be distinguished from other cell components without the application of fluorescent dyes and provides a label‐free non‐invasive drug screening assay that could be used not only with cells and tissues ex vivo but potentially also in vivo. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
U.S. M&A Market Lags Corporate Performance
Authors: Gaughan Patrick A. 
Published: December 2013

AbstractDuring 2013, the U.S. M&A market was somewhat weak‐it lagged overall corporate performance. The author explains why this has happened, takes a close look at the factors that caused it, and projects what we may expect for the future. © 2014 Wiley Periodicals, Inc.
High‐responsivity AlGaN–GaN multi‐quantum well UV photodetector
Authors: Rostami Ali , Ravanbaksh Neda , Golmohammadi Saeed , Abedi Kambiz 
Published: December 2013

AbstractIn this paper, we propose a set of AlGaN–GaN multi‐quantum well (MQW) photodetectors based on p‐i‐n heterostructures with 14 AlGaN–GaN MQW structures in i‐region, where GaN quantum well has 6 nm thickness and AlxGa1−xN barrier thickness is 3 nm. In this structure, the peak responsivity of 0.19 A/W at 246 nm is reported. In addition, we investigate effects of various parameters on responsivity, and we show that responsivity of MQW‐based photodetectors strongly depends on proper device design, that is, number of quantum wells, well thickness, barrier thickness, and mole fraction. We also show that increasing number of quantum wells, thickness of wells, and mole fraction as well as decreasing thickness of barriers, increase the responsivity. Using obtained results, we proposed optimal structure. Copyright © 2013 John Wiley & Sons, Ltd.
Dynamic behavior of a grid‐connected microgrid with power conditioning system
Authors: Chen Meng‐Jen , Wu Yu‐Chi , Huang Yu‐Xiu 
Published: December 2013

ABSTRACTThe principle concept of microgrid (MG) is to integrate loads and microsources into a controllable system to supply electric power and heat to the user. This study discussed the dynamic characteristics of a grid‐connected MG associated with power conditioning system (PCS) to regulate its power. The investigated system primarily consists of the grid, microsources, lumped static loads, and other components. Detailed models based on matlab/Simulink (MathWorks, headquarters in Natick, Massachusetts, U.S.A.) were developed to cater for the dynamic behavior of the system. Two operational modes were investigated: four‐quadrant operation of PCS and use of PCS to control the power of MG. Simulation results suggest this MG can operate satisfactorily in these operational modes. This study can serve as an important reference for planning and operation of MGs. Copyright © 2013 John Wiley & Sons, Ltd.
Application of the virtual work principle to compute magnetic forces with a volume integral method
Authors: Carpentier Anthony , Galopin Nicolas , Chadebec Olivier , Meunier Gérard , Guérin Christophe 
Published: December 2013

SUMMARYMagnetic forces are computed in the scope of magnetostatic problems solved by a volume integral method. This method uses the range interactions between magnetizable elements and is particularly well suited to compute the fields without meshing the air domain. This paper proposes an adaptation of the virtual work principle to the framework of the volume integral method in order to compute the magnetic forces. First, its application for electromagnetic devices in the nonlinear case allows to compute the global magnetic force. Second, its local application in the linear case provides a magnetic force density. 3D numerical examples are given, and the results are compared with the analytical solution and the finite element method. Copyright © 2013 John Wiley & Sons, Ltd.
A surface‐potential‐based MOSFET compact model accounting for random doping fluctuations
Authors: Donati Guerrieri S. , Cappelluti Federica , Bonani Fabrizio , Ghione Giovanni 
Published: December 2013

SUMMARYWe present a compact, surface‐potential‐based modeling approach for deeply scaled digital or radio‐frequency metal‐oxide‐semiconductor field‐effect transistor able to account for random doping fluctuations in the device channel. Random dopant fluctuations are one of the primary causes for device variability in nanometer‐scale components. The present approach is based on the Green's function formulation of the device external electrical parameters (such as the output current) small‐change sensitivity to distributed, space‐dependent doping variations in the channel; furthermore, the methodology is used also to assess the small‐signal device parameter variations within the limits of a quasi‐static description. The present approach allows for an efficient circuit‐level sensitivity analysis and has been applied to the PSP compact model through a Verilog‐A code implemented within the ADVANCED DESIGN SYSTEM (Agilent Technologies, Santa Clara, CA, U.S.A.) simulator. Examples are provided to show that the model predictions are in good agreement with far more time‐consuming simulations. Copyright © 2013 John Wiley & Sons, Ltd.
Transplant versus resection for the management of hepatocellular carcinoma meeting Milan Criteria in the MELD exception era at a single institution in a UNOS region with short wait times
Authors: Squires Malcolm H. , Hanish Steven I. , Fisher Sarah B. , Garrett Cristen , Kooby David A. , Sarmiento Juan M. , Cardona Kenneth , Adams Andrew B. , Russell Maria C. , Magliocca Joseph F. , Knechtle Stuart J. , Staley Charles A. , Maithel Shishir K. 
Published: December 2013

BackgroundManagement of hepatocellular carcinoma (HCC) in the Model for End‐Stage Liver Disease (MELD) exception era remains regionally variable. Outcomes were compared for patients undergoing transplant versus resection at a single institution in a UNOS region with short wait times for organ availability.MethodsAll patients who underwent resection of HCC from January 2000 to August 2012 and patients who underwent transplant post‐January 2006, during the Milan Criteria (MC)‐based MELD exception policy for HCC, were identified. Primary outcomes were overall survival (OS) and recurrence‐free survival (RFS).ResultsTwo hundred fifty‐seven patients were analyzed, of whom 131 underwent transplant and 126 underwent resection. All transplant patients met MC; 45 (36%) resection patients met MC. Median follow‐up time was 30 months. Median wait time to transplant was 55 days; no patients dropped off the waitlist while awaiting an organ.Among patients meeting MC, transplant demonstrated significantly greater 5‐year OS (65.7% vs. 43.8%; P = 0.005) and RFS (85.3% vs. 22.7%; P < 0.001) versus resection. For patients with hepatitis C, transplant (n = 87) demonstrated significantly improved 5‐year outcomes compared to patients meeting MC who underwent resection (n = 21; OS: 63.5% vs. 23.3%; P = 0.001; RFS: 83.5% vs. 23.7%; P < 0.001).ConclusionIn a region with short waitlist times for organ availability, liver transplant is associated with improved survival compared to resection for HCC within MC and should be considered for all patients meeting MC, particularly those with hepatitis C. J. Surg. Oncol. 2014 109:533–541. © 2013 Wiley Periodicals, Inc.
Olfactory neuroblastoma: A 35‐year experience and suggested follow‐up protocol
Authors: Rimmer Joanne , Lund Valerie J. , Beale Timothy , Wei William I. , Howard David 
Published: December 2013

Objectives/HypothesisTo validate a follow‐up protocol based on the long‐term outcomes and recurrence rates in patients who have undergone surgical treatment for olfactory neuroblastoma.MethodsA prospective review of all patients treated for olfactory neuroblastoma at our institution over a 35‐year period.ResultsNinety‐five patients were treated from 1978 to 2013, with craniofacial (65 patients) or endoscopic resection (30 patients). Duration of follow‐up ranged from 1 to 309 months (mean, 88.66 months). Fifty‐six patients were alive and well, and 13 were alive with recurrent disease. Twenty‐one patients had died of disease, and three had died of intercurrent disease. Overall survival was 83.4% at 5 years and 76.1% at 10 years. Disease‐free survival at 5 years was 80% and at 10 years was 62.8%. A Cox regression analysis showed orbital extension and intracranial involvement to be significant independent factors affecting outcome. Local and regional recurrence occurred after an average of 49 months but with a range of 3 to 233 months.ConclusionsIn our series, olfactory neuroblastoma most commonly recurred within the first 4 years but can recur very late, after 19.4 years in one case. There is currently no universally accepted follow‐up regime, but even late recurrence is eminently treatable. We therefore propose a protocol for lifelong follow‐up with both clinical examination and serial imaging, including the neck and entire intracranial compartment.Level of Evidence4 Laryngoscope, 124:1542–1549, 2014
Direct observation by in situ transmission electron microscopy of the behaviour of IF‐MoS2 nanoparticles during sliding tests: influence of the crystal structure
Authors: Lahouij Imène , Vacher Béatrice , Dassenoy Fabrice 
Published: December 2013

ABSTRACTDirect observation of the behaviour of individual inorganic fullerenes (IF)‐MoS2 nanoparticles in a sliding interface is essential for the understanding of the influence of the intrinsic characteristics of the nanoparticles on their lubrication mechanisms, when they are used as additives in lubricant oil. In this work, in situ transmission electron microscopy sliding tests were performed on two different types of MoS2 nanoparticles synthesised by two different methods. It is shown that the IF‐MoS2 nanoparticles having perfect structure with a high crystalline order and without defects are able to roll and to slide under the combined effect of pressure and shear stress, whereas the IF‐MoS2 nanoparticles containing many defects exfoliate immediately in the same conditions to deliver MoS2 layers covering the mating surfaces. A link between these results, the lubrication mechanisms of the nanoparticles and their tribological properties at the macro‐scale was established, proving that the lubrication mechanisms of fullerenes depend on their intrinsic characteristics. Copyright © 2013 John Wiley & Sons, Ltd.
Evaluating lifetime performance of limited slip differentials
Authors: Berglund Kim , Marklund Pär , Larsson Roland , Olsson Richard 
Published: December 2013

ABSTRACTExtensive research has been performed regarding wet clutch function and performance. Although wet clutches are used in both automatic transmissions and limited slip differentials in cars, most research has been performed for wet clutches incorporated in automatic transmissions. The operating conditions of wet clutches in automatic transmissions differ from the operating conditions of the wet clutches used in limited slip differentials.Therefore, a method and a test bench to use in the investigation of the degradation of limited slip differentials were developed in this work. The typical operating conditions of the limited slip differential and the differences compared with wet clutches incorporated in automatic transmissions were also addressed. Tests performed showed that the developed test bench and method can be used to address differences in frictional response over time for different types of operating conditions. Copyright © 2013 John Wiley & Sons, Ltd.
Swelling Behaviors of Poly(N‐isopropylacrylamide) Nanosized Hydrogel Particles/Poly(vinyl alcohol)/Water Systems: Effect of the Degree of Hydrolysis of PVA
Authors: Kim Sung Min , Choi Ji Su , Bae Young Chan 
Published: December 2013

Using poly(vinyl alcohol) as a drug model, the swelling behaviors of thermosensitive poly(N‐isopropylacrylamide) gel with various concentrations of PVA are investigated. The swelling ratio in PVA9000 is larger than that of PVA89000 at the same composition because the fully hydrolyzed PVA acts as a steric hindrance. A lattice‐based molecular thermodynamic model is used to obtain interaction parameters and then directly applied to describe the swelling behaviors of the gel. Using only one adjustable parameter, the PVA selectivity can be theoretically predicted and the ternary phase diagrams of PNIPA/water/PVA system can be generated. Lastly, the calculated results are compared with the swelling data for PNIPA/PVA copolymer gel, and are found to be in good agreement with the proposed model.
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Meso‐ and Microscopic Motions in Photoresponsive Liquid Crystalline Polymer Films
Authors: Seki Takahiro 
Published: December 2013

Photoresponsive azobenzene‐containing systems ranging from molecular to macroscopic material levels have greatly been increasing their significance in materials chemistry. This review focuses on the studies on light induced or triggered motions in azobenzene liquid crystalline (LC) polymer films at mesoscopic and microscopic levels. Due to the cooperative nature of liquid crystalline materials, highly efficient photoalignment and photo‐triggered migrating motions are realized in mostly repeated manners. Here, recent advances in surface‐grafted LC polymer brushes, LC block copolymer films, and LC polymer films that exhibit mass migrations are overviewed. Such newly emerged photoresponsive systems are expected to provide new possibilities and applications in polymer thin film technologies.
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Taurine‐Induced Fabrication of Nano‐Architectured Conducting Polypyrrole on Biomedical Titanium
Authors: Liao Jingwen , Pan Haobo , Ning Chengyun , Tan Guoxin , Zhou Zhengnan , Chen Junqi , Huang Shishu 
Published: December 2013

In this article, taurine, one of the small biomolecules associated with bone metabolism, is firstly utilized to induce the fabrication of nano‐architectured conducting polypyrrole (NCPPy) on biomedical titanium in diverse pH values of phosphate buffer solution (PBS). Accordingly, the possible mechanism for the fabrication of NCPPy is proposed, which is dependent on the states of polytaurine from the polymerization of taurine, i.e., the inability of forming polytaurine and unordered restricted space results in taurine‐incorporated and polytaurine‐incorporated tightly packed nanoparticles (pH 6.2 and 8.0), respectively, and however, ordered restricted space constructed by polytaurine chains induces the fabrication of polytaurine‐incorporated nanopillars (pH 6.8) and polytaurine‐incorporated nanowire networks (pH 7.4).
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Expression of far upstream element (FUSE) binding protein 1 in human glioma is correlated with c‐Myc and cell proliferation
Authors: Ding Zongmei , Liu Xiancheng , Liu Yonghua , Zhang Jianguo , Huang Xianting , Yang Xiaojing , Yao Li , Cui Gang , Wang Donglin 
Published: December 2013

AbstractGlioma is one of the most common type of primary intracranial tumor. Although great advances have been achieved in treatment of glioma, the underlying molecular mechanisms remain largely unknown. Previous studies demonstrated that FBP1 is a transcriptional regulator of c‐Myc and acts as an important prognostic indicator in many cancers. Our study aimed to assess the expression and function of FBP1 in human glioma. Immunohistochemical and Western blot analysis were performed in human glioma and normal brain tissues. High FBP1 expression (located in cell nuclei) was observed in 70 samples and its level was correlated with the grade of malignancy. A strongly positive correlation was observed between FBP1 and c‐Myc (P = 0.005) and Ki‐67 expression (P = 0.009). In a multivariate analysis, high FBP1 and c‐Myc expressions were showed to be associated with poor prognosis in glioma. While in vitro, following serum stimulation of starved U87MG cells, the expression of FBP1 was upregulated, as well as c‐Myc and PCNA. Moreover, knockdown of FBP1 by siRNA transfection diminished the expression of c‐Myc and arrested cell growth at G1 phase. Collectively, our results shows that the expression of FBP1 is in close correlation with c‐Myc level and cell proliferation in glioma and provides a potential strategy to develop FBP1 inhibitors as novel anti‐tumor agents. © 2013 Wiley Periodicals, Inc.