bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peanut Cultivar Response to Tomato Spotted Wilt over Five Planting Dates
Authors: Nuti R. C. , Chen C. Y. , Dang P. M. , Harvey J. E. 
Published: December 2013

ABSTRACT
Tomato spotted wilt virus (TSWV) is vectored by thrips and causes an economically damaging peanut disease in the southeastern U.S. Peanut planting was traditionally initiated when soil temperatures became favorable in April. Planting in the latter two thirds of May is recommended to avoid thrips feeding and reduce tomato spotted wilt (TSW) incidence. This regime concentrates work load for growers and buying points, increases risk of tropical storm damage during harvest, and may contribute to reduced crop maturity. Improved TSW tolerance in cultivars may allow growers to plant earlier spreading risk and work load. Cultivars Georgia Green, Georgia-03L, AT 3085RO, and Flavor Runner 458 were compared with the advanced breeding line EXP 271516 based on peanut foliar condition, pod yield, and grade in 2008 and 2009 in Dawson, Georgia and Headland, Alabama. Peanuts were planted at five planting dates starting in late April through early June each year. Disease incidence was variable according to year, location, and planting date. Planting dates in April and early May resulted in higher TSW incidence. Foliar TSW ratings for the susceptible cultivar Flavor Runner 458 ranged between 48–96% at harvest. Georgia Green had 10–65% TSW incidence while maintaining yields between 3,315–5,440 kg/ha. Other cultivars had better TSW tolerance resulting in higher yield under more intense TSW pressure. Planting in the middle of May or later resulted in the highest yields. Cultivars with improved tolerance to TSW maintained yield above 4,490 kg/ha in early plantings. These results indicate the least risky management is possible by planting the most TSW tolerant genotypes during the current recommended planting dates.
Differences in Coagulation between Hemodialysis and Peritoneal Dialysis
Authors: Brophy Donald F. , Carl Daniel E. , Mohammed Bassem M. , Song Jingmei , Martin Erika J. , Bostic Jessica L. , Gehr Todd W.B. 
Published: December 2013

Background End-stage renal disease patients have significant cardiovascular morbidity and mortality, but little is known about differences in coagulation profiles between patients on hemodialysis (HD) and on peritoneal dialysis (PD). Given their long-term exposure to glucose-based dialysate, patients on PD can experience metabolic derangements. Theoretically, that exposure should create a more prothrombotic environment than occurs in HD patients. The objective of the present study was to quantify potential differences in baseline coagulation between PD and HD patients. Methods Our single-center cross-sectional study at a large academic health science center enrolled 50 age-, race-, and sex-matched subjects (10 control subjects, 20 HD patients, and 20 PD patients). Measurements included platelet function, platelet receptor distribution, and coagulation dynamics by thromboelastography and Hemodyne hemostasis assay (Hemodyne, Richmond, VA, USA). Results Compared with healthy control subjects, patients on both forms of dialysis showed prothrombotic coagulation protein profiles. The tissue-factor pathway was markedly elevated in both groups, but PD was associated with significantly greater concentrations of tissue factor ( p = 0.0056) and tissue-factor pathway inhibitor ( p = 0.0138). Similarly, compared with patients receiving HD, patients on PD had greater concentrations of fibrinogen ( p = 0.0325), which corresponded with platelet hyperfunction as measured by platelet contractile force and clot elastic modulus ( p = 0.003 and 0.017 respectively, compared with values in HD patients). Platelet receptor distribution was similar between the groups. Conclusions Compared with patients on HD, patients on PD appear to have a more prothrombotic profile. The clinical relevance of these findings needs to be studied in a prospective manner.
High Glucose Concentrations in Peritoneal Dialysate are Associated with All-Cause and Cardiovascular Disease Mortality in Continuous Ambulatory Peritoneal Dialysis Patients
Authors: Wen Yueqiang , Guo Qunying , Yang Xiao , Wu Xianfeng , Feng Shaozhen , Tan Jiaqing , Xu Ricong , Yu Xueqing 
Published: December 2013

Background The effect of high peritoneal dialysate glucose concentration (PDGC) on all-cause and cardiovascular disease (CVD) mortality in peritoneal dialysis (PD) patients is unclear. Objective Our study aimed to investigate the effect of high PDGC on all-cause and CVD mortality in continuous ambulatory PD (CAPD) patients. Methods The study enrolled 716 patients newly initiated on CAPD therapy between January 2006 and December 2010. We allocated the patients to low (<1.56%), medium (≥1.56% to <1.74%), and high (≥1.74%) average PDGC groups according to the tertile of average PDGC in the first 6 months after PD initiation. Cox regression and ordinal logistic regression were used to analyze determinants of mortality and of PDGC use respectively. Results Mean follow-up in the study cohort was 31 ± 15 months. The all-cause mortality was 4.7 events per 100 patient-years, and the leading cause of death was CVD. Patients with a higher PDGC had significantly higher cumulative rates of all-cause (log-rank p < 0.001) and CVD mortality (log-rank p < 0.001). In Cox regression analysis, high PDGC independently predicted higher all-cause (hazard ratio: 2.63; p = 0.004) and CVD mortality (hazard ratio: 2.78; p = 0.01). Compared with a lower PDGC, a higher PDGC was significantly associated with older age [odds ratio (OR): 1.02; p < 0.001], low residual renal function (OR: 0.91; p < 0.001), and high dialysate-to-plasma ratio of creatinine (OR: 28.61; p < 0.001) in ordinal logistic regression. Conclusions Higher PDGC is associated with higher all-cause and CVD mortality in CAPD patients.
Clinical Features of Patients with Morphea and the Pansclerotic Subtype: A Cross-sectional Study from the Morphea in Adults and Children Cohort
Authors: Kim Andrew , Marinkovich Nicholas , Vasquez Rebecca , Jacobe Heidi T. 
Published: December 2013

Objective.Pansclerotic morphea is a poorly described form of morphea with little information on prevalence, demographics, and clinical features. Classification criteria for this subtype varies and the distinction from other forms of morphea, such as extensive generalized morphea and pansclerotic morphea, is not always clear. The purpose of our study was to clarify classification criteria for pansclerotic morphea by identifying its prevalence in the morphea in adults and children (MAC) cohort and describing its demographic and clinical features as compared with generalized morphea.Methods.Patients who met predefined criteria for generalized and pansclerotic morphea were identified using a modified Laxer and Zulian classification system. Baseline demographic and clinical features of the patients were compiled and then analyzed for traits characteristic of pansclerotic morphea versus those of generalized morphea. One hundred and thirteen patients met the criteria for inclusion: pansclerotic (n = 13) and generalized morphea type (n = 100).Results.Patients with pansclerotic morphea were more frequently male (46.2% vs 6%; p < 0.0001); had a shorter time to diagnosis (mean difference of 10.4 mos; 95% CI: 0.8–19.9 mos; p = 0.0332); higher rates of functional impairment (61.5% vs 16%; p = 0.0046); higher rates of deep involvement (61.5% vs 17%; p = 0.004); and higher average Rodnan Skin Score (mean difference of 10.8 points; 95% CI: 5–16.6; p = 0.0017), Localized Scleroderma Skin Damage Index (mean difference 28.3; 95% CI: 9–47.6; p = 0.009), and Physician Global Assessment of Disease Damage scores (mean difference 25.1; 95% CI: 0.3–50; p = 0.048).Conclusion.Our results suggest demographic and clinical features are sufficient to define the pansclerotic subtype as they represent a distinct clinical phenotype with a more rapidly progressive and severe course commonly accompanied by disability. Presence of features of the pansclerotic phenotype should alert practitioners to the possibility of significant morbidity and the need for early aggressive treatment.
Associations of Smoking and Alcohol Consumption with Disease Activity and Functional Status in Rheumatoid Arthritis
Authors: Lu Bing , Rho Young Hee , Cui Jing , Iannaccone Christine K. , Frits Michelle L. , Karlson Elizabeth W. , Shadick Nancy A. 
Published: December 2013

Objective.To investigate the associations of smoking and alcohol consumption with disease activity and functional status in rheumatoid arthritis (RA).Methods.We conducted a prospective study consisting of 662 patients with RA who were followed up to 7 years from the Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study. Smoking and alcohol consumption were assessed through yearly questionnaires. The disease activity and functional status were measured annually by the Disease Activity Score examined in 28 commonly affected joints using C-reactive protein (DAS28-CRP3) and the Modified Health Assessment Questionnaire (MHAQ). Linear mixed models were developed to assess the longitudinal effects of smoking and alcohol consumption on DAS28-CRP3 and MHAQ after adjustment for potential confounders. The HLA-DRB1 shared epitope (HLA-SE) by smoking and alcohol interactions were also evaluated in the analysis.Results.The median followup time of the cohort was 4 years. Current smoking was not associated with DAS28-CRP3 in our study, but was associated with a higher MHAQ than nonsmokers with seropositive RA (p = 0.05). Alcohol consumption showed an approximate J-shaped relationship with MHAQ, with the minima occurring at 5.1–10.0 g/day. Compared to no alcohol use, alcohol consumption of 5.1–10.0 g/day was associated with a significant decrease of MHAQ (p = 0.02). When stratified by HLA-SE, the effect of alcohol consumption appeared to be stronger in HLA-SE–positive RA than HLA-SE–negative RA.Conclusion.We found that current smoking was associated with a worse functional status, while moderate alcohol consumption was associated with a better functional status in RA. Replications of these findings in other prospective studies are needed.
Changes in Body Mass Index in Children with Juvenile Idiopathic Arthritis Treated with Tumor Necrosis Factor Inhibitors
Authors: Shafferman Ashley , Fontaine Kevin R. , Cron Randy Q. , Beukelman Timothy 
Published: December 2013

Objective.To evaluate changes in body mass index (BMI) among cohorts of children with juvenile idiopathic arthritis (JIA) with and without tumor necrosis factor (TNF) inhibitor therapy.Methods.We performed a retrospective chart review of children with JIA who newly initiated TNF inhibitor therapy and had at least 1 year of subsequent followup (TNF cohort). We also included children with JIA and at least 1 year of followup without any TNF inhibitor therapy (comparator cohort). Children with systemic arthritis were excluded. Age and sex specific BMI z-scores and their corresponding categories (normal, overweight, obese) were determined. We compared changes from a baseline visit to the last followup visit using t-test for BMI z-scores and chi square and Kruskal-Wallis tests for BMI categories.Results.The TNF cohort had 167 patients; the comparator cohort had 37. The median study followup was 2.8 and 2.2 years, respectively. The cohorts had similar age, sex, race, weight, and height distributions. The TNF cohort had a statistically significant increase in BMI z-score from baseline (+0.15; p = 0.02) that was not significantly different from the increase (+0.09) observed in the comparator cohort (p = 0.5). There was no significant change in the proportions of overweight and obese children in the TNF cohort compared to baseline (p = 0.6) or compared to the change in the comparator cohort (p = 0.2).Conclusion.Over more than 2 years of followup, we did not observe a significant increase in BMI among children with JIA receiving TNF inhibitor compared to those not receiving it.
One-year Followup Study on Clinical Findings and Changes in Magnetic Resonance Imaging-based Disease Activity Scores in Juvenile Idiopathic Arthritis
Authors: Hemke Robert , van Veenendaal Mira , van den Berg J. Merlijn , Dolman Koert M. , van Rossum Marion A.J. , Maas Mario , Kuijpers Taco W. 
Published: December 2013

Objective.To evaluate whether clinical disease activity findings during 1-year followup of patients with juvenile idiopathic arthritis (JIA) is associated with changes of magnetic resonance imaging (MRI)-based disease activity scores.Methods.Patients with JIA who had active knee involvement were studied using an open-bore MRI. After followup of a median of 1.3 years, patients were re-evaluated and classified as improved or unimproved according to the American College of Rheumatology Pediatric-50 (ACR-Ped50) criteria. Baseline and followup MRI features were scored by 2 readers using the Juvenile Arthritis MRI Scoring (JAMRIS) system, comprising validated scores for synovial hypertrophy, bone marrow changes, cartilage lesions, and bone erosions.Results.Data of 40 patients were analyzed (62.5% female, mean age 12.2 yrs). After followup, 27 patients (67.5%) were classified as clinically improved, whereas 13 patients (32.5%) showed no clinical improvement. The clinically improved patients showed a significant reduction in synovial hypertrophy scores during followup (p < 0.001), with substantial effects (standardized response mean −0.70). No such changes were observed for any of the other MRI features. Significant differences were detected regarding a change in synovial hypertrophy scores comparing clinically improved and unimproved patients (p = 0.004), without statistically significant differences for changes in scores for bone marrow changes (p = 0.079), cartilage lesions (p = 0.165), and bone erosions (p = 0.078).Conclusion.This is one of the first studies to provide evidence for MRI-based improvement upon followup in JIA patients with knee involvement. There is a strong association with clinical improvement according to the ACR-Ped50 criteria and changes in MRI-based synovial hypertrophy scores, supporting the role of MRI as a responsive outcome measure to evaluate disease activity with antiinflammatory treatment strategies.
Effect of Biologic Treatments on Growth in Children with Juvenile Idiopathic Arthritis
Authors: Uettwiller Florence , Perlbarg Julie , Pinto Graziella , Bader-Meunier Brigitte , Mouy Richard , Compeyrot-Lacassagne Sandrine , Melki Isabelle , Wouters Carine , Prieur Anne-Marie , Landais Paul , Polak Michel , Quartier Pierre 
Published: December 2013

Objective.Growth retardation is a frequent complication of severe juvenile idiopathic arthritis (JIA). Biologic treatments may improve growth velocity by controlling systemic inflammation and reducing corticosteroids. Our goals were to compare growth velocity before and after the onset of biologic therapy and to determine whether the JIA subtype, the use of steroids, the requirement of one or several biologic agents, or the disease activity influenced growth velocity.Methods.We retrospectively analyzed the growth of children with JIA who never received growth hormone treatment, who started biologic treatment before puberty, and who were followed for at least 6 months afterward.Results.We included 100 children (33 boys). Median patient age was 7.1 years (range: 1.6–15.7) at the onset of biologic treatment and 11.0 years (range: 2.3–19.5) at the latest followup. Forty-six patients had received corticosteroid and 34 had received more than 1 biologic agent. Patient median height expressed as SD score (SDS) was 0.31 (range: −2.47 to 5.46) at disease onset, −0.24 (−3.63 to 2.90) at biologic therapy onset (p < 0.0001), and −0.15 (−4.95 to 3.52) at the latest followup (p = 0.171 compared to biologic treatment onset). Patients who required several biologics and systemic patients had a significantly lower growth velocity after the onset of biologic treatment. At the latest followup, 18% of our study group had low growth velocities and 19% were below −2SD or shorter than genetically programmed.Conclusion.In a subset of patients, particularly systemic JIA patients and patients who required more than 1 biologic, biologic therapy may be insufficient to restore normal growth velocity.
Interleukin 28B Gene Polymorphisms in Hepatitis C Virus-related Cryoglobulinemic Vasculitis
Authors: Sansonno Domenico , Russi Sabino , Serviddio Gaetano , Conteduca Vincenza , D’Andrea Giovanna , Sansonno Loredana , Pavone Fabio , Lauletta Gianfranco , Mariggiò Maria Addolorata , Dammacco Franco 
Published: December 2013

Objective.Single-nucleotide polymorphisms (SNP) in the interleukin 28B (IL-28B) gene region are strongly predictive of the response of infected patients to antiviral therapy for hepatitis C virus (HCV). We sought to determine the prevalence of SNP IL-28B rs12979860 C/C and non-C/C (C/T plus T/T) genotypes in HCV-related cryoglobulinemic vasculitis (CV), as compared with HCV-positive patients without CV. We also searched for their association with peculiar clinical manifestations of CV and potential influence on the complete response (virological, molecular, and immunological) to the therapy.Methods.The study cohort comprised 159 and 172 HCV-infected patients with and without CV, respectively, prospectively followed starting from 1990. SNP rs12979860 genotyping was performed by Taq-Man allelic discrimination. In 106 patients (66.6%) with CV, the profile of circulating B cell clonalities was determined as well. All patients with CV were treated with pegylated interferon-α/ribavirin-based antiviral therapy.Results.The T/T IL-28B genotype was more common in patients with CV than in those without (17% vs 8.1%, p = 0.02). In patients with CV, compared with non-C/C variants, the IL-28B C/C genotype was associated with a higher rate of complete response (52.6% vs 39.2%, p = 0.13), whereas a treatment response of 61.4% was demonstrated when solely virological response was considered (p = 0.008). A higher frequency of expanded B cell clonalities in the circulation (84.2% vs 55.9%; p = 0.005), kidney involvement (21% vs 2.9%; p = 0.003), and B cell non-Hodgkin lymphoma (17.5% vs 6.8%; p = 0.048), were also observed.Conclusion.In HCV-positive patients with CV, the IL-28B C/C genotype is distinguished biologically by a higher frequency of restriction of B cell response and clinically by a higher risk of cryoglobulinemic nephropathy and B cell malignancies, while acting as an independent predictor of a sustained virological response to antiviral therapy. In addition, we found that IL-28B T/T variant was more prevalent in patients with CV than in those without.
Fat Infiltration on Magnetic Resonance Imaging of the Sacroiliac Joints Has Limited Diagnostic Utility in Nonradiographic Axial Spondyloarthritis
Authors: Weber Ulrich , Pedersen Susanne J. , Zubler Veronika , Rufibach Kaspar , Chan Stanley M. , Lambert Robert G.W. , Østergaard Mikkel , Maksymowych Walter P. 
Published: December 2013

Objective.To explore whether morphological features of fat infiltration (FI) on sacroiliac joint (SIJ) magnetic resonance imaging (MRI) contribute to diagnostic utility in 2 inception cohorts of patients with nonradiographic axial spondyloarthritis (nr-axSpA).Methods.Four blinded readers assessed SIJ MRI in 2 cohorts (A/B) of 157 consecutive patients with back pain who were ≤ 50 years old, and in 20 healthy controls. Patients were classified according to clinical examination and pelvic radiography as having nr-axSpA (n = 51), ankylosing spondylitis (n = 34), or nonspecific back pain (n = 72). Readers recorded FI, bone marrow edema (BME), and erosion, predefined morphological features of FI (distinct border, homogeneity, subchondral location), and anatomical distribution of SIJ FI. The proportion of SIJ quadrants affected by FI and frequencies of various SIJ FI features were analyzed descriptively. We calculated positive/negative likelihood ratios (LR) to estimate the diagnostic utility of various features of FI, with and without associated BME, and erosion.Results.Of the patients with nr-axSpA in cohorts A/B, 45.0%/48.4% had FI in ≥ 2 SIJ quadrants. Of those, 25.0%/22.6% and 20.0%/25.8% showed FI with distinct border or homogeneous pattern, respectively, and 50% to 100% of those patients displayed concomitant BME or erosion. FIper sein ≥ 2 SIJ quadrants had no diagnostic utility (LR+ 1.62/1.91). FI with distinct border (LR+ 8.29/2.13) or homogeneity (LR+ 6.24/3.78) demonstrated small to moderate diagnostic utility.Conclusion.SIJ FIper sewas not of clinical utility in recognition of nr-axSpA. Distinct border or homogeneity of FI on SIJ MRI showed small to moderate diagnostic utility in nr-axSpA, but were strongly associated with concomitant BME or erosion, highlighting the contextual interpretation of SIJ MRI.
Les multiples déterminants de la mémoire à court terme verbale : Implications théoriques et évaluatives
Authors: Majerus Steve 
Published: December 2013

Résumé Les tâches d’empan (empan de chiffres ; empan de mots) sont traditionnellement considérées comme mesurant les capacités limitées d’un système de mémoire à court terme verbale spécialisé tel que la boucle phonologique décrite par Baddeley et Hitch (1974). Cependant, de plus en plus de données montrent que ces tâches, en apparence très simples, recrutent en réalité des processus cognitifs complexes, en partie partagés avec d’autres fonctions cognitives. Parmi ces processus nous identifierons : (1) l’activation temporaire du système langagier, (2) l’attention sélective, (3) le traitement de l’ordre sériel. Nous proposerons un modèle théorique intégrant ces trois éléments comme principes de base de la mémoire à court terme verbale et de son développement chez l’enfant. Ensuite, nous développerons les implications pour l’évaluation de la mémoire à court terme verbale et les adaptations nécessaires afin de pouvoir mesurer l’intervention de chacun de ces trois éléments.
EVAL MATER : Dépistage des troubles d'apprentissage en maternelle dans la région PACA
Authors: Mancini Julien , Pech-Georgel C. , Brun-Henin Florence , George F. , Livet M.O. , Massoulier A. , Suzineau E. , Guagliardo V. , Verger Pierre 
Published: December 2013

Résumé Objectifs : Améliorer la prévention des troubles d’apprentissage. Population et Méthodes : les auteurs proposent une approche standardisée des compétences langagières et motrices d’enfants âgés de 3 ans 6 mois à 4 ans 6 mois lors de la visite systématique réalisée en école maternelle par les médecins de protection maternelle et infantile. Dans ce but une évaluation de prévalence a été réalisée chez 2 660 enfants, suivie d’une évaluation des performances chez 99 d’entre eux. 261 enfants ont ensuite été revus 2 ans plus tard et soumis à un BSEDS (Bilan de Santé Evaluation du Développement pour la Scolarité 5 à 6 ans). Résultats et discussion : l’exploitation statistique des résultats obtenus aux 2 enquêtes (prévalence puis évaluation des performances) a permis de définir des scores aidant à la décision d’une demande de bilan à visée diagnostique. La spécificité et la sensibilité des épreuves augmentent avec l’âge et sont meilleures dans le cadre des épreuves de langage. Ce nouveau bilan a reçu un accueil très positif de la part des médecins utilisateurs.