bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancements in radiocarbon dating: An overview of its impact on Mexican archaeology
Authors: Solís Corina , Rodríguez‐Ceja María , Alcántara‐Chávez Alberto , Martínez‐Carrillo Miguel Ángel 
Published: August 2024

AbstractIn this article, we provide a concise historical summary tracing the evolution of radiocarbon dating techniques in Mexico and Central America. We explore the contributions of early pioneers who first employed radiocarbon dating methods, leading to the establishment of a Mexican accelerator mass spectrometry laboratory. The study highlights its pivotal role in shaping chronological frameworks for archaeological investigations in Mexico. Additionally, we describe two noteworthy case studies—Chiquihuite Cave and Golondrinas Chasm—as exemplars of successful applications of radiocarbon dating and Bayesian analysis in contemporary archaeological practices in Mexico.
I say a little prayer for me: Poetry as spiritual self‐care in the ethnographic field
Authors: Almudéver Chanzà Josep 
Published: August 2024

AbstractHow do we make sense of our place in the field as researchers and as sexual, spiritual beings? Ethnographic fieldwork is central to several disciplines, including geography. It involves the researcher encountering and gathering stories and meanings through interaction with people's lived experiences in settings that are often not the researcher's own. Although rarely strain‐free, fieldwork is seen as a transformative experience, both from the personal and the academic point of view. This paper, situated at the intersection of geography, queer/ing practices, and ethnographic methodology, explores poetry as a form of self‐care in the field. In recent years, poetry has emerged as a creative and productive mode of representation and (co‐)interpretation of qualitative data. Based on my own spiritual experience(s) while conducting fieldwork in Spain, I consider prayer cards as a poetic form and a means through which issues of self‐care and spiritual self‐preservation are made visible, particularly when experienced within a social environment that is hostile to LGBTQ+ lived experiences of faith.
Comparison of nutrient supply from the dam to fetus and placental development in Holstein and Japanese black cows pregnant with similar or different fetus breeds
Authors: Mashimo Riku , Kumazaki Yuka , Nakagami Kaori , Kusaba Nobuyuki , Kawashima Chiho 
Published: August 2024

AbstractA lower nutrient supply from Holstein (HOL) dams to beef fetuses than HOL fetuses has been demonstrated, but the underlying factors remain unclear. We investigated maternal, umbilical vein, and calf blood glucose and amino acid concentrations at calving, along with placental development at term, in HOL dams with similar fetuses (HOL‐HOL, n = 12), F1 crosses (HOL × Japanese Black [JB]; HOL‐F1, n = 4), JB fetuses (HOL‐JB, n = 7), and JB dams with similar fetuses (JB‐JB, n = 11). Calf birth weight, total cotyledonary weight, and surface area were greater in HOL‐HOL compared to JB‐JB or HOL‐JB (P < 0.05), whereas those of HOL‐F1 were similar. Blood amino acid concentrations in the umbilical veins and calves were similar among HOL‐HOL, HOL‐F1, and HOL‐JB. Calf blood glucose concentrations were lower in HOL‐F1 than HOL‐HOL (P < 0.05), despite similar maternal blood glucose levels. HOL‐JB exhibited higher maternal, umbilical vein, and calf blood glucose concentrations than JB‐JB (P < 0.05). Therefore, the glucose supply to the fetus may be inhibited in HOL‐F1 due to maternal‐fetal breed differences. Higher maternal blood glucose concentrations in HOL‐JB may result in elevated fetal glucose exposure, potentially affecting postnatal growth and metabolism.
Novel cathepsin C inhibitor, BI 1291583, intended for treatment of bronchiectasis: Phase I characterization in healthy volunteers
Authors: Badorrek Philipp , Diefenbach Claudia , Kögler Harald , Eleftheraki Anastasia , Seitz Friedeborg , Hohlfeld Jens M. 
Published: August 2024

AbstractNovel treatments are needed to reduce inflammation, improve symptoms, address exacerbations, and slow disease progression in bronchiectasis. Cathepsin C (CatC) inhibition promises to achieve this through reduction of neutrophil‐derived serine protease (including neutrophil elastase [NE] and proteinase 3 [PR3]) activation. Here, we present the phase I characterization of the novel CatC inhibitor, BI 1291583. Five phase I trials of BI 1291583 in healthy subjects are presented: a single‐rising‐dose study (NCT03414008) and two multiple‐rising‐dose studies (NCT03868540 and NCT04866160) assessing the safety, tolerability, pharmacodynamics, and pharmacokinetics of BI 1291583; a food effect study (NCT03837964); and a drug–drug interaction study (NCT03890887) of BI 1291583 and itraconazole. BI 1291583 was safe and well tolerated across the doses tested in these trials. Most adverse events (AEs) were mild or moderate in intensity, with no serious AEs, AEs of special interest or deaths reported in any trial. Drug‐related skin exfoliation was not reported more frequently in subjects treated with BI 1291583 compared with placebo. BI 1291583 was readily absorbed, and pharmacokinetics were supra‐proportional over the dose ranges assessed. Additionally, BI 1291583 inhibited CatC in a dose‐dependent manner, inhibited downstream NE activity, and decreased PR3 levels. No food effect was observed. Co‐administration of multiple doses of itraconazole increased BI 1291583 exposure approximately twofold. Due to these promising phase I results, a multinational phase II program of BI 1291583 in adults with bronchiectasis is ongoing (Airleaf™ [NCT05238675], Clairafly™ [NCT05865886], and Clairleaf™ [NCT05846230]).
Assessing the impact of stricter drink driving policy on alcohol consumption in a population of Hanoi, Vietnam using wastewater analysis
Authors: Bui Thanh X. , Ngo Hieu K. T. , Vu Giang T. , Zheng Qiuda , Nguyen Dat M. , Hue Tran Thi Thanh , Binh Vu Ngan , Anh Nguyen Thi Kieu , Thai Phong K. 
Published: August 2024

AbstractIntroductionOn 1 January 2020, Vietnam introduced a new law with harsher fines and penalties for driving under the influence of alcohol. Reports of empty beer restaurants following this implementation suggested the new law has the potential to reduce population‐level alcohol consumption. This pilot study aims to quantify short‐term changes in alcohol consumption levels after the implementation of the new law and assess whether it could lead to a reduction in total alcohol consumption in the population.MethodsWastewater samples were collected from two sites along a sewage canal in Hanoi during two periods: Period 1 (15 December 2018 to 14 January 2019) and Period 2 (15 December 2019 to 14 January 2020). Ethyl sulfate, a specific metabolite of alcohol, was quantified to monitor the trend of alcohol consumption. Both interrupted time series and controlled interrupted time series approaches were utilised, with Period 1 and Period 2 serving as the control and intervention periods, respectively.ResultsOur analysis indicated that the implementation of the new law did not result in an immediate and significant reduction in alcohol consumption at the population level. Meanwhile, there was no significant difference in alcohol consumption between weekdays and weekends both before and after the implementation of the new law.Discussion and ConclusionsLong‐term monitoring is needed to assess the impact of stricter DUI policy on alcohol consumption in the urban areas of Vietnam.
Disentangling the Influence of Phylogeny and Traits on Climatic Risk of European Butterflies
Authors: Gianuca Andros T. , Schweiger Oliver , Bini Luis Mauricio , Wiemers Martin , di Cavalcanti Victor Rocha , Diniz‐Filho José Alexandre , WallisDeVries Michiel F. , Zimmermann Niklaus E. , Settele Josef 
Published: August 2024

ABSTRACTAimThe relative importance of traits and phylogeny to predict species extinction risk is unclear and it depends on which traits are measured and their phylogenetic conservatism. Here, we evaluate the power of functional traits, ecological characteristics, such as range size and specialization, and phylogeny to predict climatic risks in European butterflies.LocationEurope.Time PeriodDistribution data from 1981 to 2002 was used to project range shifts up to 2080.Major Taxa StudiedIn total, 268 European butterfly species (Rhopalocera).MethodsWe extracted information on climatic risk for each species from the literature. Two hypothetical conditions were assumed: full climate tracking and no climate tracking. We used variation partitioning to quantify and disentangle the effects of phylogeny, four traits (wingspan, voltinism, overwintering and egg volume) and two ecological characteristics (range size and specialization) on climatic risk. We used Random Forest as an imputation method to predict climatic risk values for additional European butterfly species that have not been previously modelled.ResultsRange size and degree of specialization strongly predicted climatic risk of European butterflies, but only for no climate tracking scenarios. Overall, more generalist species have larger ranges and are less vulnerable to climate change. Furthermore, we found that phylogenetic information adds strong power to explain climatic risk, especially, but not exclusively for scenarios that assume full climate tracking.Main ConclusionsConsidering current scenarios of habitat fragmentation in Europe, it is likely that species with smaller ranges and high degree of specialization will be unable to track their climates and thus be more at risk. However, our results imply that assisting dispersal and colonization might allow small ranged species to cope with climate change. Our analysis also indicate that phylogeny can be used as a proxy of unmeasured traits to predict climatic risk under certain circumstances.
Do analysts’ gross margin forecasts influence manager's decisions to recognize inventory losses?
Authors: Jahan Nusrat , Sivadasan Padmakumar 
Published: August 2024

AbstractAccounting standards require firms to write down their inventory when its market value (or net realizable value) drops below cost. Recognizing inventory write‐downs decreases gross margins and increases scrutiny of managers’ inventory management practices. Further, it is difficult for market participants to assess inventory balances. Therefore, managers often delay recognizing inventory losses. Compared with other analysts, analysts who issue disaggregated gross margin (GM) forecasts evaluate a firm's inventories more closely, which should motivate managers to recognize expected inventory losses. Consistent with this prediction, managers’ likelihood of recognizing an expected inventory loss increases as more analysts provide GM forecasts. However, the number of analysts issuing standalone earnings per share (EPS) or EPS and other disaggregated forecasts is not associated with inventory loss recognition. We address endogeneity concerns by documenting that firms are less likely to recognize an expected inventory loss after exogenous factors cause analysts to stop issuing GM forecasts for the firm. We contribute significantly to the literature by showing that analysts' GM forecasts are closely associated with managers’ timely inventory loss recognition. This insight bridges the gap between anecdotal evidence, which suggests analysts assess inventory carefully, and scholarly research indicating that analysts' forecasts may not fully capture the effects of inventory changes. Our findings suggest that managers act as if inventory management practices are more strictly monitored only when analysts issue GM forecasts.
Predictive significance of cardio ankle vascular index for the assessment of cardiovascular risk in hypertensive patients: A systematic review
Authors: Saravanan Chiranjeevee R. , Chowdhury Shubhayu R. , Inban Pugazhendi , Chandrasekaran Sai Harini , Pattani Himani H. , Santoshi Krupanagram , Bamba Hyma , Singh Gurmehar , Prajjwal Priyadarshi , Ranjan Raunak , Marsool Mohammed Dheyaa Marsool , Amir Omniat 
Published: August 2024

AbstractCardio‐ankle vascular index (CAVI) is an innovative indicator of large‐artery stiffness, which is evaluated by the pulse wave velocity (PWV) measurement. Mortality and morbidity due to cardiovascular diseases among the general public with high‐risk conditions such as hypertension are usually associated with arterial stiffness. CAVI modelizes the hazard of future cardiovascular events with standard risk factors. Additionally, the “European Society of Hypertension and Cardiology” included the aortic PWV assessment in managing hypertension in their updated guidelines in 2007. We conducted this systematic review to collect, summarize, and evaluate the evidence from relevant reported studies. A literature search of four databases was conducted comprehensively until February 2024. Cardiovascular events are the primary outcome of interest in this study, cardiovascular events that have been defined as major adverse cardiac events include “heart failure”, “stroke”, “myocardial infarction”, “cardiovascular deaths”, “stable angina pectoris”, “coronary revascularization”, and “unstable angina pectoris”. We included five studies with a 11 698 sample size in this systematic review. All five prospective studies investigated composite cardiovascular events as an outcome. Three of them revealed a statistically significant prediction ability of CAVI to assess Cardiovascular disease (CVD) risk. Further analysis is required. Current evidence is insufficient to confirm the predictive power of CAVI in the assessment of cardiovascular risk in hypertensive patients. CAVI is modestly associated with incidents of CVD risk. It is necessary to conduct further studies to assess CAVI concerning CVD predictor measures in the masses and nations other than Asia.
Immigrant and minority parents' experiences in a neonatal intensive care unit: A meta‐ethnography review
Authors: Trajkovski Suza , Al‐Dabbas Mahmoud A. , Raman Shanti , Giannoutsos Nicolette , Langman Margaret , Schmied Virginia 
Published: August 2024

AbstractAimsTo examine immigrant and minority parents' experiences of having a newborn infant in the neonatal intensive care unit and explore healthcare professionals' experiences in delivering care to immigrant and minority families.DesignA meta‐ethnographic review informed by eMERGe guidelines.MethodsWe conducted a systematic literature review. Studies were included if they explored immigrant or minority parent experiences in neonatal intensive care units and health professional experiences delivering care to immigrant and minority families in neonatal intensive care. Reporting followed ENTREQ guidelines.Data SourcesDatabase searches included CINAHL, MEDLINE, PubMed, PsycINFO, Scopus and Google Scholar. Boolean search strategies were used to identify qualitative studies. No limitations on commencement date; the end date was 23rd August 2022. PRISMA guidelines used for screening and article quality assessed using Joanna Briggs Institute criteria for qualitative studies.ResultsInitial search yielded 2468 articles, and nine articles met criteria for inclusion. Three overarching themes were identified: (1) Overwhelming Emotions, (subthemes: Overwhelming Inadequacy; Cultural Expressions of Guilt; Not Belonging), (2) Circles of Support, (subthemes: Individual Level‐Spirituality; External Level‐Connecting with Family; Structured Peer‐to‐Peer Support), (3) Negotiating Relationships with Healthcare Professionals (subthemes: Connecting; Disconnected; Linguistic Barriers). Interactions between healthcare professionals and immigrant and minority parents were the strongest recurring theme.ConclusionsThere can be a mismatch between immigrant and minority families' needs and the service support provided, indicating improvements in neonatal intensive care are needed. Despite challenges, parents bring cultural and family strengths that support them through this time, and many neonatal intensive care staff provide culturally respectful care.Implications for the Profession and/or Patient CareProfessionals should be encouraged to identify and work with family strengths to ensure parents feel supported in the neonatal intensive care unit. Findings can inform policy and practice development to strengthen health professionals capabilities to support immigrant and minority families in neonatal units.Reporting MethodThe Preferred Reporting Items for Systematic Reviews and Meta‐Analyses checklists were used to report the screening process.
Identifying phenotypes in persons with temporomandibular disorders using latent class analyses
Authors: Julsvoll Elisabeth Heggem , Myhrvold Birgitte Lawaetz , Waagan Knut , Vøllestad Nina Køpke , Robinson Hilde Stendal 
Published: August 2024

AbstractBackgroundThe heterogeneity of persons with temporomandibular disorders (TMD) and the lack of effective treatments have called for a biopsychosocial model and the development of a more personalised treatment approach. Emphasis on phenotypes might be a beneficial approach.ObjectiveIdentifying phenotypes among persons with TMD using potential prognostic factors, including personal characteristics and responses to clinical tests. Additionally, examining the distribution of TMD diagnoses within the identified phenotypes.MethodsA cross‐sectional study including 208 persons (85% females) seeking physiotherapy for problems in the temporomandibular area. All participants were examined clinically and answered questionnaires electronically. The phenotypes were identified using latent class analysis based on seven potential prognostic factors selected within pain, function and psychological domains. Table analysis was used to explore the distribution of TMD diagnoses within the identified phenotypes.ResultsMost participants fit into one of three identified phenotypes. Phenotype 1 (32%) was characterised by functional disability, low psychosocial scores and low risk for developing chronicity and future work disability; Phenotype 2 (29%) by parafunctional habits, low psychosocial score and seeking treatment to reduce pain; and Phenotype 3 (39%) by high levels of mental distress, fear avoidance and a large risk of future work disability. Intra‐articular disorders dominated Phenotype 1, myalgia and TMD‐related headache Phenotype 2, while Phenotype 3 included all the different TMD diagnoses.ConclusionThe knowledge about the three identified phenotypes might be useful for clinicians treating persons with TMD and for the development of preventive strategies and more personalised treatment.
Complementing electoral democracy assessment: The Plebiscitary Electoral Democracy Index and its application to the Andean Community, 2003–2022
Authors: Paredes Ana Marcela 
Published: August 2024

AbstractThis study employs the V‐Dem database and proposes an alternative calculation of the regular Electoral Democracy Index by incorporating the Direct Popular Vote Index, a component of the Participatory Democracy Index. The result is the creation of the Plebiscitary Electoral Democracy Index. To validate this index proposal, the article conducts an empirical test focusing on the Andean Community countries over the past two decades that compares the existing Electoral Democracy Index with the new proposed index from 2003 to 2022. The findings reveal that the proposed index reflects a consistently lower level of democracy than that measured by the Electoral Democracy Index across all Andean cases. This research shows how incorporating participation indicators in assessing electoral democracy reveals distinct conclusions regarding the state of democracy than those from the previously established Electoral Democracy Index. The comparatively lower levels of democracy emphasize the importance of incorporating a participatory dimension in the Electoral Democracy Index to develop a more comprehensive and regionally nuanced approach to measuring democracy that can be applied to understand better the evolution of democracy everywhere.
MicroRNAs modulate SARS‐CoV‐2 infection of primary human hepatocytes by regulating the entry factors ACE2 and TMPRSS2
Authors: Khanal Rajendra , Heinen Natalie , Bogomolova Alexandra , Meister Toni L. , Herrmann Simon T. , Westhoven Saskia , Nocke Maximilian K. , Todt Daniel , Jockenhövel Freya , Klein Isabel M. , Hartmann Laura , Vondran Florian W. R. , Steinmann Eike , Zimmer Gert , Ott Michael , Brown Richard J. P. , Sharma Amar Deep , Pfaender Stephanie 
Published: August 2024

AbstractBackground and AimsSevere acute respiratory syndrome coronavirus (SARS‐CoV‐2) preferentially infects the respiratory tract; however, several studies have implicated a multi‐organ involvement. Hepatic dysfunctions caused by SARS‐CoV‐2 infection have been increasingly recognized and described to correlate with disease severity. To elucidate molecular factors that could contribute towards hepatic infection, we concentrated on microRNAs (miRNAs), a class of small non‐coding RNAs that modulate various cellular processes and which are reported to be differentially regulated during liver injury. We aimed to study the infection of primary human hepatocytes (PHH) with SARS‐CoV‐2 and to evaluate the potential of miRNAs for modulating viral infection.MethodsWe analysed liver autopsies from a coronavirus disease 19 (COVID‐19)‐positive cohort for the presence of viral RNA using Nanopore sequencing. PHH were used for the infection with SARS‐CoV‐2. The candidate miRNAs targeting angiotensin converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) were identified using in silico approaches. To discover the potential regulatory mechanism, transfection experiments, qRT‐PCRs, western blots and luciferase reporter assays were performed.ResultsWe could detect SARS‐CoV‐2 RNA in COVID‐19‐positive liver autopsies. We show that PHH express ACE2 and TMPRSS2 and can be readily infected with SARS‐CoV‐2, resulting in robust replication. Transfection of selected miRNA mimics reduced SARS‐CoV‐2 receptor expression and SARS‐CoV‐2 burden in PHH. In silico and biochemical analyses supported a potential direct binding of miR‐141‐3p to the SARS‐CoV‐2 genome.ConclusionWe confirm that PHH are susceptible to SARS‐CoV‐2 infection and demonstrate selected miRNAs targeting SARS‐CoV‐2 entry factors and/or the viral genome reduce viral loads. These data provide novel insights into hepatic susceptibility to SARS‐CoV‐2 and associated dysfunctions in COVID‐19.
Dynamic influence of remittances on energy poverty eradication in Pakistan: A moderation analysis through consumption and investment
Authors: Bano Sadia , Khan Anwar , Murodova Gulnora 
Published: August 2024

AbstractEnergy poverty is a prevalent subject in Pakistan, and reducing it will accelerate the pace towards reaching targets of sustainable development goal 7 and carbon neutrality. Workers' remittances have proved to be a major income source in Pakistan, and it is not clear how they can be channeled to improve energy access and consumption to eradicate energy poverty. Therefore, this study is designed to investigate how remittances impact energy poverty in Pakistan, considering both weak (energy access and consumption) and strong (Multi‐Dimensional Energy Poverty Index [MDEPI]) forms of energy poverty. Data from 1990 to 2020 were gathered and analyzed using dynamic‐ARDL simulations to understand the empirical outcomes. The outcomes show that remittances effectively reduce MDEPI with a −0.056 coefficient. The results reveal that remittances reduce energy poverty through the consumption channel (−1.569); however, this relationship is ineffective in Pakistan. In the case of the weak form of energy poverty, the results supported the idea that remittances individually and through consumption and investment channels effectively alleviate energy poverty. Therefore, policies should be promoted to effectively and legally channel remittances to investment initiatives, which will build a vacuum for sustainable energy solutions and energy poverty eradication in Pakistan.