bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bronchial artery hypertrophy is correlated with coronary artery disease
Authors: Tresoldi Silvia , Di Leo Giovanni , Villa Federica , Squarza Silvia Amaryllis Claudia , Beneggi Irene Maria , Flor Nicola , Sardanelli Francesco , Cornalba Gianpaolo 
Published: August 2013

Background Bronchial arteries support the systemic pulmonary vasculature and physiologically communicate with pulmonary arteries and coronary arteries. While there is evidence supporting the link between pulmonary diseases and bronchial artery hypertrophy (BAH), few data on the correlation between coronary artery disease (CAD) and BAH have been published. Purpose To evaluate a possible association between BAH and CAD in patients without known pulmonary diseases undergoing computed tomography coronary angiography (CTCA). Material and Methods This retrospective study was approved by the local ethics committee. One hundred patients with varying degrees of CAD underwent CTCA. Patients were stratified into four groups as follows: group I, 25 patients without CAD or with non-significant CAD; group II, 25 untreated patients with significant CAD; group III, 25 stented patients; group IV, 25 patients with coronary artery bypass grafts. The number and diameter of bronchial arteries were recorded. Correlation between age, CAD, and BAH was estimated. Results One hundred and ninety-nine bronchial arteries were detected. Approximately 51% were hypertrophic (diameter, >1.5 mm) with a mean diameter of 1.7 ± 0.5 mm. Seventy-six patients showed no pulmonary alterations; 24 were found to have previously undiagnosed pulmonary findings, six of which were severe. Presence and degree of CAD correlated with patients’ mean age (60 in group I, 68 in group II, 65 in group III, 69 in group IV; P = 0.023), and mean bronchial artery transverse diameter (1.6 mm, 1.7 mm, 1.8 mm, and 2.0 mm, respectively; P = 0.009). The bronchial artery diameter was not associated with pulmonary findings ( P = 0.390). Conclusion There is an association between CAD and BAH. In patients with no pulmonary alterations, BAH could be caused by undiagnosed underlying CAD.
A motive for the use of a posterior approach in shoulder arthography: ventral leakage of contrast medium
Authors: Adriaensen Miraude EAPM , Ertl Oliver T , Laar Peter-Jan van , Nix Maarten , Vanhoenacker Filip M 
Published: August 2013

Background Some orthopedic surgeons request a posterior approach for shoulder magnetic resonance (MR) arthrography, especially in patients with anterior shoulder instability, to avoid interpretive difficulties in differentiating anterior extraarticular contrast injection when using an anterior approach from ventral leakage of contrast. Purpose To determine the occurrence of ventral leakage of contrast in shoulder MR arthrography when using a posterior approach. Material and Methods Retrospectively, we included 73 consecutive patients who underwent shoulder MR arthrography (1.0 Tesla) using the posterior approach. Three unsuccessful procedures were excluded. Ventral leakage of contrast, defined as contrast seen around the musculus subscapularis without distention of the posterior capsule, was recorded. Descriptive statistics were used. Results Seventy shoulders were included. Forty-one left shoulders were involved (59%). Mean age of patients was 49 years (range, 17–76 years). Thirty-five patients were women (50%). Ventral leakage of contrast was seen in 12 shoulders (17%). Conclusion As ventral leakage of contrast was seen in a substantial number of cases when using a posterior approach in shoulder MR arthrography, the use of a posterior approach is advised to avoid misinterpretation of ventral contrast leakage with accidental extra articular contrast injection, and to increase confidence in the final radiological diagnosis.
Results of Arthroscopic Labral Reconstruction of the Hip in Elite Athletes
Authors: Boykin Robert E. , Patterson Diana , Briggs Karen K. , Dee Ashley , Philippon Marc J. 
Published: August 2013

Background: Femoroacetabular impingement (FAI) has been well characterized as a cause of hip pain and resultant damage to the acetabular labrum. It has become increasingly clear that an intact labrum is essential for normal joint mechanics, hip stability, and preservation of the articular cartilage. Elite athletes with a hypoplastic or irreparable labrum present a difficult clinical challenge. Purpose: To assess clinical outcomes and determine if elite athletes are able to return to a high level of function and sport after labral reconstruction. Study Design: Case series; Level of evidence, 4. Methods: A retrospective review of a prospectively collected registry identified 21 elite athletes (23 hips) with an average age of 28.0 years (range, 19-41 years) who underwent an arthroscopic iliotibial band labral reconstruction. Concomitant procedures included femoral and acetabular osteoplasty in all patients and microfracture in 9 of 23 hips. Clinical outcomes were assessed with the modified Harris Hip Score (MHHS), the Hip Outcome Score (HOS), the Short Form–12 (SF-12), and patient satisfaction (on a scale from 1-10). Return to play was determined, as well as level of return to play, based on sport-specific statistics. Results: Two patients progressed to arthroplasty. There were 2 revisions in this group of patients, both for lysis of capsulolabral adhesions in which the graft was found to be well integrated at the time of surgery. The rate of return to play was 85.7% (18/21), with 81% (17/21) returning to a similar level. Subjective follow-up was obtained from 17 of the remaining 19 patients (89%), with an average follow-up of 41.4 months (range, 20-74 months). The average MHHS improved from 67 to 84 ( P = .026) and the average HOS Sport subscore from 56 to 77 ( P = .009). The overall median patient satisfaction with outcome was 8.2 (range, 3-10). Conclusion: Arthroscopic labral reconstruction using an ipsilateral iliotibial band autograft provides good short-term clinical outcomes, high patient satisfaction, and a satisfactory level of return to play in a select group of elite athletes.
Passive Anterior Tibial Subluxation in Anterior Cruciate Ligament–Deficient Knees
Authors: Tanaka Miho J. , Jones Kristofer J. , Gargiulo Andrew M. , Delos Demetris , Wickiewicz Thomas L. , Potter Hollis G. , Pearle Andrew D. 
Published: August 2013

Background: Abnormal anterior-posterior and rotational motion secondary to anterior cruciate ligament (ACL) insufficiency is typically described in terms of dynamic laxity. An original description of the abnormal tibiofemoral relationship in the setting of ACL insufficiency has highlighted the presence of a fixed anterior tibial subluxation in this population of failed ACL reconstruction (ACLR); however, no study has quantified the degree of tibial subluxation in both the medial and lateral compartments. Purpose: To measure and compare the amount of anterior tibial subluxation among various states of ACL competency, including (1) intact ACL, (2) acute ACL disruption, and (3) failed ACLR (ie, patients requiring revision ACLR). We hypothesized that anterior tibial displacement would be greater in the lateral compartment and in cases of failed ACLR compared with intact and acute ACL injured states. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Using sagittal magnetic resonance imaging (MRI) and a standardized measurement technique, we determined the amount of anterior tibial subluxation relative to a constant posterior condylar reference point. Measurements were performed in both the medial and the lateral compartments and were compared with 1-way analysis of variance. The presence of meniscal tears along with meniscal volume loss and chondral damage was correlated with the amount of subluxation in each group. Results: Compared with the intact ACL state, the medial tibial plateau was positioned more anteriorly relative to the femur in both acute ACL injured knees (mean 1.0 mm) and those that failed ACLR (mean 1.8 mm) ( P = .072). In the lateral compartment, there was 0.8 mm of mean anterior tibial displacement after acute ACL injury and 3.9 mm of mean anterior subluxation in patients who failed ACLR ( P < .001). Mean anterior displacement of the lateral plateau in patients who failed ACLR was almost 5 times greater than the amount observed in patients with acute ACL injuries. There was no correlation between meniscal/chondral injury and the amount of subluxation. Conclusion: Patients who require revision ACLR have an abnormal tibiofemoral relationship noted on MRI that is most pronounced in the lateral compartment and should be taken into account during revision surgery. These observations may explain the suboptimal clinical results seen in some patients who undergo revision ACLR.
The effect of lead exposure on tracheal responsiveness to methacholine and ovalbumin, total and differential white blood cells count, and serum levels of immunoglobulin E, histamine, and cytokines in guinea pigs
Authors: Farkhondeh T , Boskabady MH , Jalali S , Bayrami G 
Published: August 2013

The effect of exposure to inhaled lead acetate in guinea pigs was evaluated. The present study comprised of five groups of guinea pigs including control (C), sensitized to ovalbumin (OA; S) and three groups exposed to 0.1, 0.2, and 0.4 M inhaled lead (Pb; n = 6 for each group). Tracheal responsiveness to methacholine and OA, total and differential white blood cells (WBCs) count in lung lavage, serum levels of cytokines (interferon γ (IFN-γ) and interleukin 4 (IL-4)), histamines, and immunoglobulin E (IgE), and Pb concentration in lung were measured. Tracheal responsiveness to methacholine, OA, total and differential WBC types as well as IL-4, IFN-γ, histamine, and IgE were significantly increased but IFN-γ/IL-4 were significantly decreased in sensitized animals as well as those exposed to high Pb concentrations when compared with the control group (from p < 0.05 to p < 0.001). In addition, there was not a significant difference in most measured values between animals exposed to high Pb concentration and group S. The Pb concentration in lung tissues of animals exposed to all three Pb concentrations was significantly higher than that of group C ( p < 0.001 for all cases).These results showed that inhaled lead acetate exposure can induce lung inflammatory changes similar to sensitized animals. Therefore, exposure to environmental Pb pollution may cause asthma-like changes.
The clinical manifestations and survival of systemic lupus erythematosus patients in Turkey: report from two centers
Authors: Pamuk ON , Akbay FG , Dönmez S , Yılmaz N , Calayır GB , Yavuz S 
Published: August 2013

Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a variety of clinical features. Survival has become longer as a result of better treatment modalities and better supportive care. There is no information on survival of SLE patients in Turkey. We evaluated clinical features and survival in SLE patients in two rheumatology departments. Methods All SLE patients being followed up by the Department of Rheumatology, Trakya University Medical Faculty, and the Department of Rheumatology, Marmara University Medical Faculty, over the 1996–2012 period were included. Patients were diagnosed with SLE if they fulfilled at least four American College of Rheumatology (ACR) criteria. The clinical and laboratory features, mortality data were obtained from medical charts. Results We had 428 SLE patients, and women (399 patients, 93.2%) far outnumbered men (29 patients, 6.8%). The mean age at the time of SLE diagnosis was 40.3 ± 12.4 years. The most frequent clinical manifestations were arthritis (76.9%) and photosensitivity (70.1%). Renal disease was present in 32.9% of patients and neurological involvement in 12.9% of patients. After a median follow-up of 60 months, 19 patients died. The most frequent causes of death were ischemic heart disease, chronic renal failure and sepsis. The rate of five-year survival was 96%; 10-year survival, 92%; and 15-year survival, 88.8%. Multivariate Cox analysis showed that serositis at the time of diagnosis, SLE disease activity index (SLEDAI) score 6, and autoimmune hemolytic anemia were independent prognostic factors. Conclusions Data from two centers in Northwestern Turkey show that the mortality rate for SLE is similar to the rate in Western countries.
The importance of visceral fat mass in obese pregnant women and relation with pregnancy outcomes
Authors: Balani Jyoti , Hyer Steve , Johnson Antoinette , Shehata Hassan 
Published: August 2013

Background Maternal obesity is a well established risk factor for gestational diabetes but it is not known if the pattern of maternal fat distribution predicts adverse pregnancy outcomes. Methods Body composition was assessed by bioimpedance using Inbody 720® in 302 consecutive obese pregnant women attending a weight management clinic. The relation of visceral fat mass and total percentage body fat with the development of gestational diabetes and perinatal outcomes was evaluated. Results Women developing gestational diabetes (Group 1; n = 72) were older, had higher body mass indices and greater central obesity (waist:hip ratio, visceral fat mass) compared with those remaining normoglycaemic. Visceral fat mass, but not percentage body fat, correlated with fasting glucose in all patients ( r = 0.2, p < 0.001) and particularly those in Group 1 ( r = 0.35, p = 0.002). Visceral fat mass, but not percentage body fat, also correlated strongly with glycaemia, particularly in Group 1 ( r = 0.47, p < 0.0001). Visceral fat mass also showed a weak but significant correlation with baby weight ( r = 0.17, p = 0.01). Discussion Central obesity, as assessed by early pregnancy waist:hip ratio and particularly by visceral fat mass, is a predictor of gestational diabetes in addition to classical risk factors and may help identify those obese patients at increased risk of complications.
RETRACTED: Nut consumption with risk of hypertension and type 2 diabetes mellitus: A meta-analysis of prospective cohort studies
Authors: Guo Kai , Jiang Yibo , Zhou Zhiwen , Li Yigang 
Published: August 2013

BackgroundThe consumption of nuts was reported to be associated with risk of hypertension and type 2 diabetes mellitus (T2DM), but the results were inconclusive. The aim of this study was to systematically examine longitudinal studies investigating nut intake in relation to risk of hypertension and T2DM.MethodsA systematic search of the PubMed and EMBASE databases to 31 March 2013 was performed. Reference lists of retrieved articles were also screened. Summary relative risks (SRRs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Q and I2statistics were used to examine between-study heterogeneity.ResultsA total of nine prospective cohort studies (three for hypertension and six for T2DM) were identified. Using random effects models, we found that based on the highest vs lowest analysis, nut consumption were inversely associated with risk of hypertension (SRR = 0.84, 95% CI: 0.76–0.93, pheterogeneity = 0.831, I2 = 0%). Dose-response analyses indicated that nut consumption at more than two servings/wk, but not ne serving/wk, had a preventative role in the hypertension. In addition, nut consumption was not associated with risk of T2DM (SRRs = 0.98, 95% CI: 0.84–1.15; pheterogeneity = 0.008, I2 = 67.7%) on the basis of the highest vs lowest analysis. This null association was also shown in the dose-response analysis.ConclusionIn our meta-analysis, nut consumption is found to be inversely associated with hypertension risk but is not associated with the risk of T2DM.
Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma
Authors: Bonetti Paola , Testoni Monica , Scandurra Marta , Ponzoni Maurilio , Piva Roberto , Mensah Afua A. , Rinaldi Andrea , Kwee Ivo , Tibiletti Maria Grazia , Iqbal Javeed , Greiner Timothy C. , Chan Wing-Chung , Gaidano Gianluca , Piris Miguel A. , Cavalli Franco , Zucca Emanuele , Inghirami Giorgio , Bertoni Francesco 
Published: August 2013

Key Points
A recurrent gain of a region of chromosome 11 (11q24.3) occurs in up to one-quarter of cases of diffuse large B-cell lymphoma. ETS1 and FLI1 genes are overexpressed and determine proliferation, survival, and differentiation arrest of the lymphoma cells.
Genetically coupled receptor–ligand pair NKp80-AICL enables autonomous control of human NK cell responses
Authors: Klimosch Sascha N. , Bartel Yvonne , Wiemann Stefan , Steinle Alexander 
Published: August 2013

Key PointsHuman NK cells contain Golgi complex–associated intracellular stores of AICL, a ligand of the activating NK receptor NKp80. Upon exposure to inflammatory cytokines, AICL surfaces on NK cells, rendering them susceptible to NKp80-mediated bystander NK cytolysis.
A simple methodology to assess endolysosomal protease activity involved in antigen processing in human primary cells
Authors: Vaithilingam Archana , Lai Nicole Y , Duong Ellen , Boucau Julie , Xu Yang , Shimada Mariko , Gandhi Malini , Le Gall Sylvie 
Published: August 2013

Abstract

Background
Endolysosomes play a key role in maintaining the homeostasis of the cell. They are made of a complex set of proteins that degrade lipids, proteins and sugars. Studies involving endolysosome contribution to cellular functions such as MHC class I and II epitope production have used recombinant endolysosomal proteins, knockout mice that lack one of the enzymes or purified organelles from human tissue. Each of these approaches has some caveats in analyzing endolysosomal enzyme functions.

Results
In this study, we have developed a simple methodology to assess endolysosomal protease activity. By varying the pH in crude lysate from human peripheral blood mononuclear cells (PBMCs), we documented increased endolysosomal cathepsin activity in acidic conditions. Using this new method, we showed that the degradation of HIV peptides in low pH extracts analyzed by mass spectrometry followed similar kinetics and degradation patterns as those performed with purified endolysosomes.

Conclusion
By using crude lysate in the place of purified organelles this method will be a quick and useful tool to assess endolysosomal protease activities in primary cells of limited availability. This quick method will especially be useful to screen peptide susceptibility to degradation in endolysosomal compartments for antigen processing studies, following which detailed analysis using purified organelles may be used to study specific peptides.
Genotype is an important determinant factor of host susceptibility to periodontitis in the Collaborative Cross and inbred mouse populations
Authors: Shusterman Ariel , Salyma Yasser , Nashef Aysar , Soller Morris , Wilensky Asaf , Mott Richard , Weiss Ervin I , Houri-Haddad Yael , Iraqi Fuad A 
Published: August 2013

AbstractBackgroundPeriodontal infection (Periodontitis) is a chronic inflammatory disease, which results in the breakdown of the supporting tissues of the teeth. Previous epidemiological studies have suggested that resistance to chronic periodontitis is controlled to some extent by genetic factors of the host. The aim of this study was to determine the phenotypic response of inbred and Collaborative Cross (CC) mouse populations to periodontal bacterial challenge, using an experimental periodontitis model. In this model, mice are co-infected withPorphyromonas gingivalisandFusobacterium nucleatum, bacterial strains associated with human periodontal disease. Six weeks following the infection, the maxillary jaws were harvested and analyzed for alveolar bone loss relative to uninfected controls, using computerized microtomography (microCT). Initially, four commercial inbred mouse strains were examined to calibrate the procedure and test for gender effects. Subsequently, we applied the same protocol to 23 lines (at inbreeding generations 10–18) from the newly developed mouse genetic reference population, the Collaborative Cross (CC) to determine heritability and genetic variation of control bone volume prior to infection (CBV, naïve bone volume around the teeth of uninfected mice), and residual bone volume (RBV, bone volume after infection) and loss of bone volume (LBV, the difference between CBV and RBV) following infection.ResultsBALB/CJ mice were highly susceptible (P<0.05) whereas DBA/2J, C57BL/6J and A/J mice were resistant. Six lines of the tested CC population were susceptible, whereas the remaining lines were resistant to alveolar bone loss. Gender effects on bone volume were tested across the four inbred and 23 CC lines, and found not to be significant. Based on ANOVA analyses, broad-sense heritabilities were statistically significant and equal to 0.4 for CBV and 0.2 for LBV.ConclusionsThe moderate heritability values indicate that the variation in host susceptibility to the disease is controlled to an appreciable extent by genetic factors. These results strongly support the possibility of using the Collaborative Cross, as well as developing dedicated F2 (resistant x susceptible inbred strains) resource populations, for future dissection of genetic factors in periodontitis.
Expression of SV2 isoforms during rodent brain development
Authors: Crèvecœur Julie , Foerch Patrik , Doupagne Melissa , Thielen Caroline , Vandenplas Catherine , Moonen Gustave , Deprez Manuel , Rogister Bernard 
Published: August 2013

Abstract

Background
SV2A, SV2B and SV2C are synaptic vesicle proteins that are structurally related to members of the major facilitator superfamily (MFS). The function and transported substrate of the SV2 proteins is not clearly defined although they are linked to neurotransmitters release in a presynaptic calcium concentration-dependent manner. SV2A and SV2B exhibit broad expression in the central nervous system while SV2C appears to be more restricted in defined areas such as striatum. SV2A knockout mice start to display generalized seizures at a late developmental stage, around post-natal day 7 (P7), and die around P15. More recently, SV2A was demonstrated to be the molecular target of levetiracetam, an approved anti-epileptic drug (AED). The purpose of this work was to precisely analyze and quantify the SV2A, SV2B and SV2C expression during brain development to understand the contribution of these proteins in brain development and their impact on epileptic seizures.

Results
First, we systematically analyzed by immunohistofluorescence, the SV2A, SV2B and SV2C expression during mouse brain development, from embryonic day 12 (E12) to P30. This semi-quantitative approach suggests a modulation of SV2A and SV2B expression in hippocampus around P7. This is the reason why we used various quantitative approaches (laser microdissection of whole hippocampus followed by qRT-PCR and western blot analysis) indicating that SV2A and SV2B expression increased between P5 and P7 and remained stable between P7 and P10. Moreover, the increase of SV2A expression in the hippocampus at P7 was mainly observed in the CA1 region while SV2B expression in this region remains stable.

Conclusions
The observed alterations of SV2A expression in hippocampus are consistent with the appearance of seizures in SV2A−/− animals at early postnatal age and the hypothesis that SV2A absence favors epileptic seizures around P7.