bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancing campus and community sustainability: strategic alliances in action
Authors: Bilodeau Leanne , Podger Jackie , Abd-El-Aziz Alaa 
Published: March 2014

Purpose– Universities can provide a leadership role to develop and mobilize knowledge to meet societal needs. In fulfilling this mission, universities can also serve as agents of sustainable development on campus and in communities they serve. The purpose of this article is to describe the drivers that have advanced the University of British Columbia Okanagan campus' operational and academic sustainability objectives; the initiatives and partnerships developed on campus and in the community in response to these drivers; and the outcomes and lessons learned.Design/methodology/approach– This article summarizes the experience of the University of British Columbia Okanagan campus in leveraging key drivers to develop sustainability initiatives and partnerships for greater operational efficiencies, cost savings, environmental stewardship and applied research. The university's leadership commitment to sustainability, economic opportunities and provincial legislative requirements are among the drivers discussed. This paper also provides an innovative partnership framework to support sustainable community development.Findings– Drivers of sustainability in higher education can contribute to the development of sustainability initiatives and partnerships that benefit institutions and communities and achieve operational and academic sustainability mandates.Practical implications– This article provides information that can be applied by institutions of higher education to advance sustainability within the context of current economic conditions and societal needs.Originality/value– The experience of the campus and the partnership framework presented in this paper is original. The framework provides a mechanism to engage students, faculty and the community in sustainable community development research. Key insights from multiple perspectives and lessons learned are shared.
Sales and operations planning
Authors: E. Plank Richard , Hooker Robert 
Published: March 2014

Purpose– The purpose of this paper is to outline the usage of interactive marketing tools in the area of sales and operations planning (S&OP) to further collaboration among supply chain partners. Emergent challenges and research directions are proposed.Design/methodology/approach– Using extant literature from S&OP, supply chain management and interactive marketing, the authors integrate those to show the value of using interactive marketing tools to further integration across the supply chain of important S&OP processes.Findings– S&OP utilizes sophisticated software to integrate various business processes beyond B2C and into B2B relationships.Research limitations/implications– Uncertainty exists as to the measurement of the performance of a supply chain, or the network or system of companies, is not developed enough to deal with that issue. However, this is addressed in the research questions section.Practical implications– The practical implications for the use of integrative marketing tools to link B2C as well as B2B partners through S&OP are numerous and far reaching.Originality/value– This study uniquely examines the use of interactive marketing tools for B2B, as opposed to simply B2C.
Global use and access of social networking web sites: a national culture perspective
Authors: Gong Wen , L. Stump Rodney , G. Li Zhan 
Published: March 2014

Purpose– This study aims to investigate the role and effect of national culture on social networking web sites (SNWs) use and access across countries while controlling for socio-economic factors, specifically networked readiness, level of education and mobile penetration.Design/methodology/approach– Hofstede's multidimensional framework serves as the conceptual basis for the study. Hierarchical regressions are conducted to test the hypothesized effects of cultural dimensions beyond that of the control variables on the penetration of SNWs using a secondary dataset for 36 countries.Findings– The results provide supporting empirical evidence linking three of Hofstede's cultural dimensions to nations' SNWs use and access.Research limitations/implications– Limitations include the use of secondary data for a limited number of countries. Only three social-economic variables were included as controls on the relationship between culture and SNWs access and usage. Future research will benefit from examining other cultural frameworks (such as Hall's classifications) and potential factors such as a nation's demographic composition and their roles in adoption and diffusion of the SNWs. Further research is needed to validate the results by including more nations and employing time-series data of social media penetration and diffusion.Practical implications– Managerial implications are discussed with respect to formulating more effective online marketing strategies for brand engagement and promotional media choice by accommodating for cultural differences.Originality/value– The paper's original contribution stems from the fact that little can be found in the literature about the influence of national culture on the use of social media. It attempts to establish the importance of understanding cultural impact on consumers' SNWs adoption behavior across countries.
Why is liberal education so incoherent? An anthropological perspective
Authors: Bates Graber Robert 
Published: March 2014

Purpose
– This paper's purpose is to account for liberal education's characteristic incoherence.

Design/methodology/approach
– Its approach is to sketch a dilemma created by cultures being inherently conservative, while nations, in order to be internationally competitive, need to be innovative. The definitional and systemic bases of culture's conservatism offer no point of attack; but a third base is enculturation, which does.

Findings
– Shortly after puberty, society's more promising young people are strongly urged to leave home for an extended period, and be exposed to ways of acting and thinking that often clash with how they have been brought up. They are encouraged to explore new subjects and indulge their curiosity; they are encouraged to “think outside the box” of their own enculturation. The incoherence of liberal education leaves them not with a sense of closure, but in a state of constructive confusion conducive to innovation in all aspects of life. Liberal education thus serves the social function of countering the anti-innovative tendency of culture.

Practical implications
– Attempts to impose coherence on undergraduate educational experience by “tying things all together” for students are ill-advised.

Originality/value
– Seeing incoherence as a desirable rather than deplorable feature of undergraduate liberal education can help us facilitate rather than inadvertently inhibit innovative thought and action in the rising generation.
The reflective practitioner: the role of a public liberal-arts university in saving liberal education
Authors: D. Paino Troy 
Published: March 2014

Purpose
– This paper seeks to discuss the role of a public liberal-arts university in education.

Design/methodology/approach
– The author first defines the principles and definitions of liberal education, then analyses these ideas in relation to public liberal-arts universities.

Findings
– Liberal education holds enduring value in a world where state support for higher education is steadily decreasing and the author concludes that society needs public liberal-arts universities in order to maintain freedom of thought and democracies.

Originality/value
– This piece presents a view of public liberal-arts universities in the wider context of liberal education, recession and worldwide threats to democracy and personal freedoms.
Integration and the liberal arts: a historical overview
Authors: Conrad Leon 
Published: March 2014

Purpose–The traditional liberal-arts curriculum of the word-based Trivium (grammar, dialectic/logic, rhetoric) and the number-based Quadrivium (arithmetic, geometry, astronomy, music) has an intrinsic unity. Used in an integrated way, it provides a tool for self-development, self-realisation and self-integration. The purpose of this paper is to outline the core nature of the integrative quality of the liberal-arts curriculum, trace the gradual disintegration of the curriculum from its adoption in classical Greece, and provide practical suggestions for the re-integration of the curriculum in the context of modern educational practice.Design/methodology/approach–The paper presents a philosophical survey of the history of the theory and practice relating to the intrinsic integrated quality of liberal-arts education from pre-classical Greece to the present day.Findings–The integrated quality of the liberal-arts curriculum has experienced a gradual disintegration from its adoption in classical Greece to the twenty-first century. The paper provides practical suggestions for the re-integration of an integrated approach to the curriculum in the context of modern educational practice.Practical implications–Re-engaging with the integrated quality of the liberal-arts curriculum is vital for fulfilling the purpose of education as a practice: that of enabling a human being to flourish in a holistic way, in order to take an active role within a civil society.Originality/value–The paper provides a valuable antidote to overly rational thinking by arguing for the need to restore the intrinsic integrative quality of the liberal-arts curriculum in educational practice in order to support the flourishing of individuals, society in order for the emergence of a mutually supportive interaction between them to appear.
Empowering leadership, employee goal orientations and work performance
Authors: I. Wong Humborstad Sut , G.L. Nerstad Christina , Dysvik Anders 
Published: March 2014

Purpose– The purpose of this paper is to investigate the possible curvilinear relationship between empowering leadership and individual in-role and extra-role work performance and the potential moderating role of individual goal orientations.Design/methodology/approach– Hierarchical regression analyses were conducted based on data from 655 certified accountants. Leaders' empowering behavior was measured using Ahearneet al.'s scale. Mastery and performance goal orientations were measured using items from VandeWalle. In-role work performance was measured via a ten-item scale developed and used by Kuvaas and Dysvik. Organizational citizenship behavior was measured using items validated by Van Dyne and LePine.Findings– Too little empowerment might have a negative or limited impact – or none at all – on individual in-role and extra-role work performance. In addition, individual mastery orientation positively moderates these curvilinear relationships.Research limitations/implications– Empowering leadership-employee performance relationships are not necessarily linear. The present study provides an alternative explanation to the somewhat inconsistent findings in the current literature.Practical implications– Due to the curvilinear nature of empowering leadership, leaders should not just casually adopt this leadership style but ensure that they implement it at high levels with clear clarification of the goals and work roles.Originality/value– Even though empowering leadership is important to individual performance, scant research has explored whether and when empowering leadership could be detrimental. This study provides an additional view to empowerment research by examining the potential curvilinear influence of empowering leadership.
Factors influencing employee satisfaction in the police service: the case of Slovenia
Authors: Tomaževič Nina , Seljak Janko , Aristovnik Aleksander 
Published: March 2014

Purpose– The paper has two purposes – first, to examine the dimensionality of employee satisfaction and, second, to identify the impact of the groups of factors on employee satisfaction.Design/methodology/approach– The measurement of satisfaction of all employees in the Slovenian Police based on the comprehensive on-line questionnaire. Factor analysis was used to formulate the facets of satisfaction. Multiple linear regression analysis was performed to identify the predictors of three facets of employee satisfaction.Findings– Three facets of employee satisfaction were determined and the influence of three types of factors (demographic, job-related and organizational-support-related factors) on them was investigated. The results show that the worst assessed facet was salary and security, whereas no significant differences were found between two other facets, namely relationships and leadership, and tasks and working conditions. The three factors influenced employee satisfaction with different levels of intensity.Research limitations/implications– The current economic situation in the state, especially in the public sector and in the police service, definitely impacts the results of the survey. The survey was conducted just before the announcement of savings measures in the Slovenian public sector. Since it was conducted on-line, it has to be assumed that for some employees this probably meant that anonymity could not be assured.Practical implications– The survey was performed in order to identify the opportunities for improvements in police management. The results indicate the importance of leadership, communication and participation in the work of police officers, especially during a period of limited financial resources.Originality/value– The paper shows that the strongest influence, by far, on employee satisfaction is that of the employees' feeling that the police will support and protect them in case they are exposed while performing their legitimate and professional work. Trust in one's immediate superior also has a strong influence. Both could be an important signal to the management of the police to focus on activities to increase cohesiveness within the police and constantly promote the feeling of belongingness to the police among all its members.
Cryptic species diversity: an overlooked factor in environmental management?
Authors: Feckler Alexander , Zubrod Jochen P. , Thielsch Anne , Schwenk Klaus , Schulz Ralf , Bundschuh Mirco 
Published: March 2014

Summary

Molecular genetic methods continuously uncover cryptic lineages harboured by various species. However, from an applied perspective, it remains unclear whether and to which extent such a genetic diversity affects biological traits (e.g. ecological, behavioural and physiological characteristics) and environmental management.

We assessed potential deviations regarding the trait ‘environmental stress tolerance’ using individuals from five field populations of each of two cryptic lineages (called A and B) comprised under the nominal species Gammarus fossarum. We used ammonia as a chemical stressor while assessing the feeding rate on leaf discs as a measure of sublethal response. In this context, we established a restriction fragment length polymorphism assay to allow a rapid identification of the lineages.

We observed a biologically meaningful and statistically significant twofold higher overall tolerance of one cryptic lineage, lineage B, over the other. Confounding factors that may have the potential to influence the test results, such as life stage, sex, season of collection, parasitism, physiological status of organisms and upstream land‐use patterns of the river catchments, were either controlled for or displayed only minor deviations between lineages.

Synthesis and applications. The trait differences observed in the present study seem to be mainly explained by the considerable genetic differentiation between cryptic lineages of one nominal species. Although traits other than tolerance have been minimally investigated in this context, this study indicates implications in the reliability and quality of environmental monitoring and management if cryptic lineage complexes are ignored.
Pregnancy outcome following maternal use of zanamivir or oseltamivir during the 2009 influenza A/H1N1 pandemic: a national prospective surveillance study
Authors: Dunstan HJ , Mill AC , Stephens S , Yates LM , Thomas SHL 
Published: March 2014

ObjectiveTo conduct enhanced surveillance for signals of teratogenesis following use of the neuraminidase inhibitors zanamivir and oseltamivir in the treatment or post‐exposure prophylaxis of 2009 A/H1N1 influenza during pregnancy.DesignProspective cohort study, using national surveillance data collected by the UK Teratology Information Service (UKTIS) during the 2009 A/H1N1 pandemic.SettingUnited Kingdom.PopulationPregnant women who were reported to UKTIS by healthcare professionals seeking advice about exposure to zanamivir and oseltamivir or to other non‐teratogenic drugs.MethodsPregnancy outcomes were collected for prospectively reported pregnancies exposed to zanamivir (n = 180) or oseltamivir (n = 27), and compared with a reference group of 575 prospectively reported pregnancies exposed to non‐teratogenic drugs over the same period.Main outcome measuresRates of major congenital malformation, preterm delivery and low birth weight.ResultsNo significant differences in overall rates of major malformation in live‐born infants [adjusted odds ratios (aOR): zanamivir 0.37 (95% confidence interval 0.02–2.70); oseltamivir aOR 0.81 (0.05, 14.15)], preterm delivery [aOR: zanamivir 0.95 (0.45, 1.89); oseltamivir aOR 1.68 (0.38, 5.38)] or low birth weight [aOR: zanamivir 0.94 (0.25, 2.90); oseltamivir aOR 4.12 (0.59, 17.99)] were observed following exposure at any gestation. No major malformations were reported in 37 zanamivir or eight oseltamivir first trimester exposures.ConclusionThese surveillance data do not provide a signal that use of zanamivir or oseltamivir in pregnancy is associated with an increased risk of the adverse pregnancy outcomes studied but the data are too limited to state conclusively that there is no increase in risk.
Concomitant oral and intravenous pharmacokinetics of trametinib, a MEK inhibitor, in subjects with solid tumours
Authors: Leonowens Cathrine , Pendry Carolyn , Bauman John , Young Graeme C. , Ho May , Henriquez Frank , Fang Lei , Morrison Royce A. , Orford Keith , Ouellet Daniele 
Published: March 2014

AimsThe aim of this phase 1, single centre, open label study in four patients with solid tumours was to determine the absolute bioavailability of a 2 mg oral dose of trametinib. Trametinib is an orally bioavailable, reversible and selective allosteric inhibitor of MEK1 and MEK2 activation and kinase activity.MethodsA microtracer study approach, in which a 5 μg radiolabelled i.v. microdose of trametinib was given concomitantly with an unlabelled 2 mg oral tablet formulation, was used to recover i.v. and oral pharmacokinetic parameters, simultaneously.ResultsThe least‐squares mean (90% confidence interval) absolute bioavailability of trametinib (2 mg tablet) was 72.3% (50.0%, 104.6%). Median tmax after oral administration was 1.5 h and the geometric mean terminal half‐life was 11 days. The geometric mean clearance and volume of distribution after i.v. administration were 3.21 l h−1 and 976 l, respectively, resulting in a terminal elimination half‐life of 11 days.ConclusionsTrametinib absolute bioavailability was moderate to high, whereas first pass metabolism was low.
Modulation of gamma globin genes expression by histone deacetylase inhibitors: an in vitro study
Authors: Ronzoni Luisa , Sonzogni Laura , Fossati Gianluca , Modena Daniela , Trombetta Elena , Porretti Laura , Cappellini Maria Domenica 
Published: March 2014

SummaryInduction of fetal haemoglobin (HbF) is a promising therapeutic approach for the treatment of β‐thalassaemia and sickle cell disease (SCD). Several pharmacological agents, such as hydroxycarbamide (HC) and butyrates, have been shown to induce the γ‐globin genes (HBG1, HBG2). However, their therapeutic use is limited due to weak efficacy and an inhibitory effect on erythroid differentiation. Thus, more effective agents are needed. The histone deacetylase (HDAC) inhibitors are potential therapeutic haemoglobin (Hb) inducers able to modulate gene expression through pleiotropic mechanisms. We investigated the effects of a HDAC inhibitor, Givinostat (GVS), on erythropoiesis and haemoglobin synthesis and compared it with sodium butyrate and HC. We used an in vitro erythropoiesis model derived from peripheral CD34+ cells of healthy volunteers and SCD donors. GVS effects on erythroid proliferation and differentiation and on Hb synthesis were investigated. We found that GVS at high concentrations delayed erythroid differentiation with no specific effect on HBG1/2 transcription. At a low concentration (1 nmol/l), GVS induced Hb production with no effects on cells proliferation and differentiation. The efficacy of GVS 1 mol/l in Hb induction in vitro was comparable to that of HC and butyrate. Our results support the evaluation of GVS as a new candidate molecule for the treatment of the haemoglobinophathies due to its positive effects on haemoglobin production at low and non‐toxic concentrations.
Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole
Authors: Frezzato Federica , Trimarco Valentina , Martini Veronica , Gattazzo Cristina , Ave Elisa , Visentin Andrea , Cabrelle Anna , Olivieri Valeria , Zambello Renato , Facco Monica , Zonta Francesca , Cristiani Andrea , Brunati Anna Maria , Moro Stefano , Semenzato Gianpietro , Trentin Livio 
Published: March 2014

SummaryFunctional abnormalities of chronic lymphocytic leukaemia (CLL) cells may be related to the microtubular network of cell cytoskeleton; specifically tubulin involvement in cells after B‐cell receptor engagement. As microtubule inhibitors could represent a therapeutic strategy for CLL, this study investigated the capability of nocodazole, a synthetic depolymerizing agent, to kill CLL leukaemic cells. We demonstrated that nocodazole was highly specific for the in vitro induction of apoptosis in leukaemic cells from 90 CLL patients, without affecting the viability of T‐cells and/or mesenchymal stromal cells (MSCs) recovered from the same patients. Nocodazole was observed to overcome the pro‐survival signals provided by MSCs. Competing with ATP for the nucleotide‐binding site, nocodazole has been observed to turn off the high basal tyrosine phosphorylation of leukaemic cells mediated by the Src‐kinase Lyn. Considering that most anti‐microtubule drugs have limited clinical use because of their strong toxic effects, the high selectivity of nocodazole for leukaemic cells in CLL and its capability to bypass microenvironmental pro‐survival stimuli, suggests the use of this inhibitor for designing new therapeutic strategies in CLL treatment.