bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finding an (Ecological) Niche in the Postdigital Taskscape: The Role of Strong Literacy and Poor Pedagogy in Primary School Pupils’ Online Literacy Practices
Authors: Hawley Sara 
Published: June 2024

AbstractThis paper uses a postdigital, postphenomenological lens to examine what happened when an online platform, a wiki, was used to support writing practices in an inner London Key Stage 2 classroom. It understands a postdigital approach to education as one which takes account of the imbrication of technology in our everyday life without valorising it or making hyperbolic claims about what it can do. Avoiding utopian or dystopian accounts, it unpicks what happened when students were allowed to compose multimodal texts beyond the classroom on topics that interested them. Using a postphenomenological approach, it looks at the materiality of the technology in praxis in the different spaces where it was used. It uses as a heuristic Ingold’s concept of the taskscape, recently developed by various scholars as a site not of romantic bucolic human activity but as somewhere where sociomaterial practices are contested as we wrestle for resources within our immediate environment. As students travel between these different taskscapes of home, school and the wiki, it examines how they enact the affordances around them in their transformation from apprentices to more skilled practitioners of literacy. It follows their trajectories-of-becoming when they move between these taskscapes, growing into knowledge as they weave lines of literacy across online and offline spaces. It argues that reviving Gibson’s notion of the ‘ecological niche’ allows us to understand why some find the paths between these spaces easier to tread than others.
The Extended Anderson and Hauck Tests and Sample Size Procedures for Equivalence Assessment in Simple Linear Regressions
Authors: Shieh Gwowen 
Published: June 2024

AbstractThis study describes extended Anderson and Hauck procedures for equivalence testing of slope coefficients and mean responses in one and two regression lines. The general formulation of asymmetric equivalence ranges permits a wide variety of equivalence questions to be tested for a target magnitude or a negligible value. Specifically, the equivalence tests are useful for assessing negligible trend and similar response in a single regression line, and for evaluating unimportant interaction-moderation effect and comparable simple effect between two linear regression lines. The associated power functions and sample size procedures are also derived and compared under the random and fixed model settings. According to the analytic justification and empirical assessment, the exact approaches have a clear advantage over the approximate formulas for accommodating the full stochastic nature of both the response and predictor variables. Computer algorithms are also provided for conducting the proposed equivalence tests, power calculations, and sample size determinations in simple linear regressions.
Bidirectional Associations of Adolescents’ Momentary Social Media Use and Negative Emotions
Authors: Colasante Tyler , Faulkner Katie , Kharbotli Dana , Malti Tina , Hollenstein Tom 
Published: June 2024

AbstractPublic discourse and empirical studies have predominantly focused on the negative repercussions of social media on adolescents’ mental health. However, pervasive social media use is a relatively new phenomenon—its apparent harms have been widely accepted before sufficient longitudinal and experimental research has been conducted. The present study used an intensive longitudinal design (four assessments/day × 14 days; N = 154 12- to 15-year-olds (Mage = 13.47, SD = 0.58); N = 6,240 valid measurement occasions) to test the directionality of social media–negative emotion links in early adolescence, accounting for the type of social media usage (i.e., browsing vs. posting). The significance of effects depended on social media type: browsing predicted higher-than-usual negative emotions hours later, whereas no significant directional effects emerged for posting. The browsing effect was small but held after controlling for prior levels of negative emotions. It did not replicate concurrently, underscoring the importance of process-oriented designs with mental health symptoms tested shortly after passive social media usage. The results partially support the active-passive hypothesis, which singles out passively engaging with others’ curated social media content as most detrimental to mental health. Nonetheless, the small browsing effect and overall null-leaning pattern of effects imply that mediators and moderators are needed to further understand when using social media is problematic, beneficial, or neither.
Urbanisation on the coastline of the most populous and developed state of Brazil: the extent of coastal hardening and occupations in low-elevation zones
Authors: Pardal André , Christofoletti Ronaldo Adriano , Martinez Aline Sbizera 
Published: June 2024

AbstractWorldwide, coastlines have been replaced and altered by hard infrastructures to protect cities and accommodate human activities. In addition, human settlements are common and increasing in lowland areas threatened by coastal risk hazards. These urbanisation processes cause severe socioeconomic and ecological losses which demand policy reforms towards better coastal management and climate resilience. A first step in that direction is to comprehend the status of coastal hardening and occupation of vulnerable areas. Here, we mapped the coastline of the most populous and developed state of Brazil: São Paulo (SP). Our goal was to quantify the linear extent of natural habitats, artificial structures (AS), and occupations in low-elevation coastal zones (≤ 5 m) within 100 m from marine environments (LECZ100m) along the coastline and within estuaries. SP coast has a total extent of 244 km of AS, of which 125 and 119 km correspond to AS running along the coastline (e.g., seawalls, breakwaters) and extending from the shoreline into adjacent waters (e.g., jetties, pontoons, groynes), respectively. 63% of the total extent of AS is located in the most urbanised region. Breakwalls were the most common infrastructure (108 km), followed by jetties and wharves (~40 km each), and aquaculture and fishing apparatus (~24 km). Over 300 km of the SP coastline has inland occupations in LECZ100m: 235 and 67 km are adjacent to sandy beaches and estuarine/river margins, respectively. Coastal hardening is advanced in the central region of SP resulting from intense port activities and armoured shorelines. In other regions, much of coastal urbanisation seems to be driven by secondary usage of the cities, such as real estate development for beach houses and tourism. Our findings suggest that coastal urbanisation poses a major but often neglected source of environmental impact and risk hazards in SP and Brazil.
Polar Lows and Their Effects on Sea Ice and the Upper Ocean in the Iceland, Greenland, and Labrador Seas
Authors: Gutjahr O. , Mehlmann C. 
Published: June 2024

AbstractUsing two case studies, we analyze the effects of explicitly resolving polar lows in a global climate model (ICON‐Sapphire) with a high resolution of 2.5 km on the upper ocean and sea ice. We aim to understand the mechanism of how polar lows form in a global coupled model and how they interact with the upper ocean and sea ice. When polar lows form at the sea ice edge, they induce marine cold air outbreaks that lead to large heat loss from the ocean. This heat loss contributes to dense water formation in the Iceland and Greenland Seas, which replenishes the climatically important Denmark Strait Overflow Water (DSOW). The high wind speeds of polar lows open leads and polynyas in the sea ice cover, such as the Sirius Water Polynya in northeastern Greenland. Heat loss in polynyas is compensated for by the formation of new ice, and the rejected brine densifies the water on the Greenland shelf. In the Labrador Sea, polar lows intensify cold air outbreaks from the sea ice and rapidly deepen the ocean mixed layer. Resolving polar lows and kinematic features in the sea ice improves the realism of climate models, in particular the surface heat loss and the dense water formation in (sub)polar oceans.
Entrained Water in Basal Ice Suppresses Radar Bed‐Echo Power at Active Subglacial Lakes
Authors: Hills B. H. , Siegfried M. R. , Schroeder D. M. 
Published: June 2024

AbstractSubglacial lakes have been mapped across Antarctica with two methods, radio‐echo sounding (RES) and ice‐surface deformation. At sites where both are coincident, these methods typically provide conflicting interpretations about the ice‐bed interface. With a single exception, active subglacial lakes identified by surface deformation do not display the expected flat, bright, and specular bed reflection in RES data, characteristic of non‐active lakes. This observational conundrum suggests that our understanding of Antarctic subglacial hydrology, especially beneath important fast‐moving ice streams, remains incomplete. Here, we use an airborne RES campaign that surveyed a well‐characterized group of active subglacial lakes on lower Mercer and Whillans ice streams, West Antarctica, to explore inconsistency between the two observational techniques. We test hypotheses of increased scattering and attenuation due to the presence of an active subglacial lake system that could suppress reflected bed‐echo power for RES observations in these locations, finding that entrained water is most plausible.
EventLFM: event camera integrated Fourier light field microscopy for ultrafast 3D imaging
Authors: Guo Ruipeng , Yang Qianwan , Chang Andrew S. , Hu Guorong , Greene Joseph , Gabel Christopher V. , You Sixian , Tian Lei 
Published: June 2024

AbstractUltrafast 3D imaging is indispensable for visualizing complex and dynamic biological processes. Conventional scanning-based techniques necessitate an inherent trade-off between acquisition speed and space-bandwidth product (SBP). Emerging single-shot 3D wide-field techniques offer a promising alternative but are bottlenecked by the synchronous readout constraints of conventional CMOS systems, thus restricting data throughput to maintain high SBP at limited frame rates. To address this, we introduce EventLFM, a straightforward and cost-effective system that overcomes these challenges by integrating an event camera with Fourier light field microscopy (LFM), a state-of-the-art single-shot 3D wide-field imaging technique. The event camera operates on a novel asynchronous readout architecture, thereby bypassing the frame rate limitations inherent to conventional CMOS systems. We further develop a simple and robust event-driven LFM reconstruction algorithm that can reliably reconstruct 3D dynamics from the unique spatiotemporal measurements captured by EventLFM. Experimental results demonstrate that EventLFM can robustly reconstruct fast-moving and rapidly blinking 3D fluorescent samples at kHz frame rates. Furthermore, we highlight EventLFM’s capability for imaging of blinking neuronal signals in scattering mouse brain tissues and 3D tracking of GFP-labeled neurons in freely moving C. elegans. We believe that the combined ultrafast speed and large 3D SBP offered by EventLFM may open up new possibilities across many biomedical applications.
Geministatins: new depside antibiotics from the fungus Austroacremonium gemini
Authors: Crombie Andrew , Kalaitzis John A. , Chen Rachel , Vuong Daniel , Lacey Alastair E. , Lacey Ernest , Shivas Roger G. , Tan Yu Pei , Sbaraini Nicolau , Chooi Yit-Heng , Piggott Andrew M. 
Published: June 2024

AbstractTwo new depside antibiotics, geministatins A (1) and B (2), were isolated from the fungus Austroacremonium gemini MST-FP2131 (Sordariomycetes, Ascomycota), which was recovered from rotting wood in the wet tropics of northern Australia. The structures of the geministatins were elucidated by detailed spectroscopic analysis, chemical degradation and comparison with literature values. Chemical degradation of 1 and 2 yielded three new analogues, geministatins C–E (3–5), as well as a previously reported compound dehydromerulinic acid A (6). Compounds 1, 2 and 6 exhibited antibacterial activity against the Gram-positive bacteria Bacillus subtilis (MIC 0.2–1.6 µg mL−1) and Staphylococcus aureus (MIC 0.78–6.3 µg mL−1), including methicillin-resistant S. aureus (MRSA), while 4 exhibited antifungal activity against the yeast Saccharomyces cerevisiae (MIC 13 µg mL−1).
AI-based histopathology image analysis reveals a distinct subset of endometrial cancers
Authors: Darbandsari Amirali , Farahani Hossein , Asadi Maryam , Wiens Matthew , Cochrane Dawn , Khajegili Mirabadi Ali , Jamieson Amy , Farnell David , Ahmadvand Pouya , Douglas Maxwell , Leung Samuel , Abolmaesumi Purang , Jones Steven J. M. , Talhouk Aline , Kommoss Stefan , Gilks C. Blake , Huntsman David G. , Singh Naveena , McAlpine Jessica N. , Bashashati Ali 
Published: June 2024

AbstractEndometrial cancer (EC) has four molecular subtypes with strong prognostic value and therapeutic implications. The most common subtype (NSMP; No Specific Molecular Profile) is assigned after exclusion of the defining features of the other three molecular subtypes and includes patients with heterogeneous clinical outcomes. In this study, we employ artificial intelligence (AI)-powered histopathology image analysis to differentiate between p53abn and NSMP EC subtypes and consequently identify a sub-group of NSMP EC patients that has markedly inferior progression-free and disease-specific survival (termed ‘p53abn-like NSMP’), in a discovery cohort of 368 patients and two independent validation cohorts of 290 and 614 from other centers. Shallow whole genome sequencing reveals a higher burden of copy number abnormalities in the ‘p53abn-like NSMP’ group compared to NSMP, suggesting that this group is biologically distinct compared to other NSMP ECs. Our work demonstrates the power of AI to detect prognostically different and otherwise unrecognizable subsets of EC where conventional and standard molecular or pathologic criteria fall short, refining image-based tumor classification. This study’s findings are applicable exclusively to females.
Divergent landscapes of A-to-I editing in postmortem and living human brain
Authors: Rodriguez de los Santos Miguel , Kopell Brian H. , Buxbaum Grice Ariela , Ganesh Gauri , Yang Andy , Amini Pardis , Liharska Lora E. , Vornholt Eric , Fullard John F. , Dong Pengfei , Park Eric , Zipkowitz Sarah , Kaji Deepak A. , Thompson Ryan C. , Liu Donjing , Park You Jeong , Cheng Esther , Ziafat Kimia , Moya Emily , Fennessy Brian , Wilkins Lillian , Silk Hannah , Linares Lisa M. , Sullivan Brendan , Cohen Vanessa , Kota Prashant , Feng Claudia , Johnson Jessica S. , Rieder Marysia-Kolbe , Scarpa Joseph , Nadkarni Girish N. , Wang Minghui , Zhang Bin , Sklar Pamela , Beckmann Noam D. , Schadt Eric E. , Roussos Panos , Charney Alexander W. , Breen Michael S. 
Published: June 2024

AbstractAdenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA modification within the brain. Yet, most research has relied on postmortem samples, assuming it is an accurate representation of RNA biology in the living brain. We challenge this assumption by comparing A-to-I editing between postmortem and living prefrontal cortical tissues. Major differences were found, with over 70,000 A-to-I sites showing higher editing levels in postmortem tissues. Increased A-to-I editing in postmortem tissues is linked to higher ADAR and ADARB1 expression, is more pronounced in non-neuronal cells, and indicative of postmortem activation of inflammation and hypoxia. Higher A-to-I editing in living tissues marks sites that are evolutionarily preserved, synaptic, developmentally timed, and disrupted in neurological conditions. Common genetic variants were also found to differentially affect A-to-I editing levels in living versus postmortem tissues. Collectively, these discoveries offer more nuanced and accurate insights into the regulatory mechanisms of RNA editing in the human brain.
Achieving a solar-to-chemical efficiency of 3.6% in ambient conditions by inhibiting interlayer charges transport
Authors: Huang Yuyan , Shen Minhui , Yan Huijie , He Yingge , Xu Jianqiao , Zhu Fang , Yang Xin , Ye Yu-Xin , Ouyang Gangfeng 
Published: June 2024

AbstractEfficiently converting solar energy into chemical energy remains a formidable challenge in artificial photosynthetic systems. To date, rarely has an artificial photosynthetic system operating in the open air surpassed the highest solar-to-biomass conversion efficiency (1%) observed in plants. In this study, we present a three-dimension polymeric photocatalyst achieving a solar-to-H2O2 conversion efficiency of 3.6% under ambient conditions, including real water, open air, and room temperature. The impressive performance is attributed to the efficient storage of electrons inside materials via expeditious intramolecular charge transfer, and the fast extraction of the stored electrons by O2 that can diffuse into the internal pores of the self-supporting three-dimensional material. This construction strategy suppresses the interlayer transfer of excitons, polarizers and carriers, effectively increases the utilization of internal excitons to 82%. This breakthrough provides a perspective to substantially enhance photocatalytic performance and bear substantial implications for sustainable energy generation and environmental remediation.
3D oxygen vacancy distribution and defect-property relations in an oxide heterostructure
Authors: Hunnestad Kasper A. , Das Hena , Hatzoglou Constantinos , Holtz Megan , Brooks Charles M. , van Helvoort Antonius T. J. , Muller David A. , Schlom Darrell G. , Mundy Julia A. , Meier Dennis 
Published: June 2024

AbstractOxide heterostructures exhibit a vast variety of unique physical properties. Examples are unconventional superconductivity in layered nickelates and topological polar order in (PbTiO3)n/(SrTiO3)n superlattices. Although it is clear that variations in oxygen content are crucial for the electronic correlation phenomena in oxides, it remains a major challenge to quantify their impact. Here, we measure the chemical composition in multiferroic (LuFeO3)9/(LuFe2O4)1 superlattices, mapping correlations between the distribution of oxygen vacancies and the electric and magnetic properties. Using atom probe tomography, we observe oxygen vacancies arranging in a layered three-dimensional structure with a local density on the order of 1014 cm−2, congruent with the formula-unit-thick ferrimagnetic LuFe2O4 layers. The vacancy order is promoted by the locally reduced formation energy and plays a key role in stabilizing the ferroelectric domains and ferrimagnetism in the LuFeO3 and LuFe2O4 layers, respectively. The results demonstrate pronounced interactions between oxygen vacancies and the multiferroic order in this system and establish an approach for quantifying the oxygen defects with atomic-scale precision in 3D, giving new opportunities for deterministic defect-enabled property control in oxide heterostructures.
Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires
Authors: Schoelmerich Marie C. , Ly Lynn , West-Roberts Jacob , Shi Ling-Dong , Shen Cong , Malvankar Nikhil S. , Taib Najwa , Gribaldo Simonetta , Woodcroft Ben J. , Schadt Christopher W. , Al-Shayeb Basem , Dai Xiaoguang , Mozsary Christopher , Hickey Scott , He Christine , Beaulaurier John , Juul Sissel , Sachdeva Rohan , Banfield Jillian F. 
Published: June 2024

AbstractBorgs are huge extrachromosomal elements (ECE) of anaerobic methane-consuming “Candidatus Methanoperedens” archaea. Here, we used nanopore sequencing to validate published complete genomes curated from short reads and to reconstruct new genomes. 13 complete and four near-complete linear genomes share 40 genes that define a largely syntenous genome backbone. We use these conserved genes to identify new Borgs from peatland soil and to delineate Borg phylogeny, revealing two major clades. Remarkably, Borg genes encoding nanowire-like electron-transferring cytochromes and cell surface proteins are more highly expressed than those of host Methanoperedens, indicating that Borgs augment the Methanoperedens activity in situ. We reconstructed the first complete 4.00 Mbp genome for a Methanoperedens that is inferred to be a Borg host and predicted its methylation motifs, which differ from pervasive TC and CC methylation motifs of the Borgs. Thus, methylation may enable Methanoperedens to distinguish their genomes from those of Borgs. Very high Borg to Methanoperedens ratios and structural predictions suggest that Borgs may be capable of encapsulation. The findings clearly define Borgs as a distinct class of ECE with shared genomic signatures, establish their diversification from a common ancestor with genetic inheritance, and raise the possibility of periodic existence outside of host cells.
Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists
Authors: Karim Ashty S. , Brown Dylan M. , Archuleta Chloé M. , Grannan Sharisse , Aristilde Ludmilla , Goyal Yogesh , Leonard Josh N. , Mangan Niall M. , Prindle Arthur , Rocklin Gabriel J. , Tyo Keith J. , Zoloth Laurie , Jewett Michael C. , Calkins Susanna , Kamat Neha P. , Tullman-Ercek Danielle , Lucks Julius B. 
Published: June 2024

AbstractSynthetic biology allows us to reuse, repurpose, and reconfigure biological systems to address society’s most pressing challenges. Developing biotechnologies in this way requires integrating concepts across disciplines, posing challenges to educating students with diverse expertise. We created a framework for synthetic biology training that deconstructs biotechnologies across scales—molecular, circuit/network, cell/cell-free systems, biological communities, and societal—giving students a holistic toolkit to integrate cross-disciplinary concepts towards responsible innovation of successful biotechnologies. We present this framework, lessons learned, and inclusive teaching materials to allow its adaption to train the next generation of synthetic biologists.
An ultrawide-range photochromic molecular fluorescence emitter
Authors: Chen Xiao , Hou Xiao-Fang , Chen Xu-Man , Li Quan 
Published: June 2024

AbstractPhotocontrollable luminescent molecular switches capable of changing emitting color have been regarded as the ideal integration between intelligent and luminescent materials. A remaining challenge is to combine good luminescence properties with wide range of wavelength transformation, especially when confined in a single molecular system that forms well-defined nanostructures. Here, we report a π-expanded photochromic molecular photoswitch, which allows for the comprehensive achievements including wide emission wavelength variation (240 nm wide, 400–640 nm), high photoisomerization extent (95%), and pure emission color (<100 nm of full width at half maximum). We take the advantageous mechanism of modulating self-assembly and intramolecular charge transfer in the synthesis and construction, and further realize the full color emission by simple photocontrol. Based on this, both photoactivated anti-counterfeiting function and self-erasing photowriting films are achieved of fluorescence. This work will provide insight into the design of intelligent optical materials.