bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coordinated Regulation of miR-155 and miR-146a Genes during Induction of Endotoxin Tolerance in Macrophages
Authors: Doxaki Christina , Kampranis Sotirios C. , Eliopoulos Aristides G. , Spilianakis Charalampos , Tsatsanis Christos 
Published: November 2015

Abstract
Endotoxin tolerance occurs to protect the organism from hyperactivation of innate immune responses, primarily mediated by macrophages. Regulation of endotoxin tolerance occurs at multiple levels of cell responses and requires significant changes in gene expression. In the process of macrophage activation, induced expression of microRNA (miR)-155 and miR-146a contributes to the regulation of the inflammatory response and endotoxin tolerance. In this article, we demonstrate that expression of both miRNAs is coordinately regulated during endotoxin tolerance by a complex mechanism that involves monoallelic interchromosomal association, alterations in histone methyl marks, and transcription factor binding. Upon activation of naive macrophages, Histone3 was trimethylated at lysine4 and NFκBp65 was bound on both miR-155 and miR-146a gene loci. However, at the stage of endotoxin tolerance, both miR gene loci were occupied by C/EBPβ, NFκBp50, and the repressive Histone3 marks trimethylation of K9 of H3. DNA fluorescence in situ hybridization experiments revealed monoallelic interchromosomal colocalization of miR-155 and miR-146a gene loci at the stage of endotoxin tolerance, whereas RNA-DNA-fluorescence in situ hybridization experiments showed that the colocalized alleles were silenced, suggesting a common repression mechanism. Genetic ablation of Akt1, which is known to abrogate endotoxin tolerance, abolished induction of loci colocalization and C/EBPβ binding, further supporting that this mechanism occurs specifically in endotoxin tolerance. Overall, this study demonstrates that two miRNAs are coordinately regulated via gene colocalization at the three-dimensional chromatin space, same transcriptional machinery, and similar Histone3 methylation profile, contributing to the development of endotoxin tolerance.
A Novel Function for P2Y2 in Myeloid Recipient–Derived Cells during Graft-versus-Host Disease
Authors: Klämbt Verena , Wohlfeil Sebastian A. , Schwab Lukas , Hülsdünker Jan , Ayata Korcan , Apostolova Petya , Schmitt-Graeff Annette , Dierbach Heide , Prinz Gabriele , Follo Marie , Prinz Marco , Idzko Marco , Zeiser Robert 
Published: November 2015

Abstract
Acute graft-versus-host disease (GvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation. During the initiation phase of acute GvHD, endogenous danger signals such as ATP are released and inform the innate immune system via activation of the purinergic receptor P2X7 that a noninfectious damage has occurred. A second ATP-activated purinergic receptor involved in inflammatory diseases is P2Y2. In this study, we used P2y2−/− mice to test the role of this receptor in GvHD. P2y2−/− recipients experienced reduced GvHD-related mortality, IL-6 levels, enterocyte apoptosis, and histopathology scores. Chimeric mice with P2y2 deficiency restricted to hematopoietic tissues survived longer after GvHD induction than did wild-type mice. P2y2 deficiency of the recipient was connected to lower levels of myeloperoxidase in the intestinal tract of mice developing GvHD and a reduced myeloid cell signature. Selective deficiency of P2Y2 in inflammatory monocytes decreased GvHD severity. Mechanistically, P2y2−/− inflammatory monocytes displayed defective ERK activation and reactive oxygen species production. Compatible with a role of P2Y2 in human GvHD, the frequency of P2Y2+ cells in inflamed GvHD lesions correlated with histopathological GvHD severity. Our findings indicate a novel function for P2Y2 in ATP-activated recipient myeloid cells during GvHD, which could be exploited when targeting danger signals to prevent GvHD.
PISMS: Parental Influence on Student Motivation and Self-esteem in Primary Education
Authors: Ghilay Yaron , Ghilay Ruth 
Published: November 2015

<p>The study presents a new model for primary education called PISMS (Parental Influence on Student Motivation and Self-esteem). Previous model named ISMS (Improving Student Motivation and Self-esteem) is designed to help schools foster motivation and self-esteem of students. PISMS is a complementary model because it allows schools to train parents how to become involved and to continue strengthening the mission of the school to improve students' motivation and self-esteem.</p><p>Parents who participated in a three-year study conducted in a primary school (n = 73), reported that a course based on the principles of PISMS, was very helpful in strengthening their ability of how to improve their children's motivation and self-esteem. The significance of these findings is that an additional method for improving key variables having an essential impact on student learning, has been found.</p><p>The PISMS model has been found to be applicable to primary education, in particular, but it may be suitable for other schools as well. </p>
Comentario al libro Imaginarios sobre la comunicación: Algunas certezas y muchas incertidumbres en torno a los estudios de comunicación, hoy de Marta Rizo García
Authors: Pérez Picado Anielka Ma. 
Published: November 2015

Esta obra de la Dra. Marta Rizo García nos ofrece una perspectiva de los estudios de la comunicación como fenómeno social, campo académico y profesional. Así mismo, nos presenta una “radiografía” de los planes de estudio de las escuelas y facultades de comunicación de la Ciudad de México. La investigación ofreció la oportunidad de “escuchar” a los estudiantes de comunicación de la Ciudad de México, cuáles son sus expectativas al ingresar a la carrera, qué entienden por comunicación y cómo se “imaginan” ejerciendo la profesión.
Ruimte voor strategie
Authors: van der Steen Martijn , Klijn Erik-Hans , van Twist Mark , van Wijk Arno , Scherpenisse Jorren 
Published: November 2015

Ruimte voor strategie: de relatie tussen toezicht en media nader bezien
Dit artikel behandelt de relatie tussen toezicht en de media. De auteurs zetten in dit artikel rond dit thema twee stappen. De eerste stap is dat ze de relatie tussen media en toezicht bezien voorbij het vaak gevestigde beeld van de problematische medialogica, die het toezicht – en het beleid – vooral in de weg zit. In de tweede stap betogen ze hetzelfde, maar dan meer empirisch. Hun onderzoek geeft inzicht in de percepties van professionals uit het toezicht over media.
Het politieke perspectief
Authors: de Bruijn Hans 
Published: November 2015

Het politieke perspectief: de kritiek van de WRR op politici en bestuurders
In het rapport deelt de WRR op z’n minst twee tikken uit aan de politiek: politici respecteren onvoldoende de onafhankelijkheid van de toezichthouder en zijn te vaak gefixeerd op de kosten en lasten van toezicht. De auteur vertaalt de twee tikken in drie kanttekeningen bij het rapport.
Naar een verruimd perspectief op rijkstoezicht
Authors: Mertens Ferdinand 
Published: November 2015

Naar een verruimd perspectief op rijkstoezicht: de WRR is nog niet klaar!
In deze bijdrage geeft de auteur een antwoord op de vraag of hij zich als inspecteur-generaal door dit rapport geholpen zou voelen. Naar zijn oordeel is de WRR nog niet klaar met zijn taak.
Management of Post-Rhytidectomy Sialocele
Authors: Soneru Christian P. , Geroulis Anthony J. 
Published: November 2015

Introduction: Inadvertent damage to the parotid gland parenchyma or ductal drainage system is a rare yet devastating complication of cervicofacial rhytidectomy. Here we describe the management of such a case. Materials and Methods: A 66-year-old woman underwent uneventful rhytidectomy and presented postoperatively with a facial sialocele. Pressure dressings, antibiotics, and serial aspirations were the initial measures used. As the leakage was recalcitrant, botulinum toxin A was injected locally and both transdermal and oral anticholinergics were prescribed. Results: After a steady decrease in the volume of fluid that accumulated, the sialocele resolved on postoperative day 44. After rhytidectomy, damage to the parotid gland can lead to leakage of saliva in the form of a sialocele or a salivary fistula. Discussion: Management options include pressure dressings, drain placement, serial aspirations, anticholinergics, chemical denervation, or parotidectomy. As the drainage may persist for a considerable duration, good communication between the patient and the physician is paramount.
Biophysical Basics of Body Treatments: A Preliminary Study into the Correlation between Washout and Circumference Reduction
Authors: Kruglikov Ilja L. 
Published: November 2015

Introduction: Clinical studies in the field of body contouring generally demonstrate a high dispersion of treatment results, which reflects the natural inhomogeneity of clinical groups. This inhomogeneity may also be connected to the existence of both hypertrophic and hyperplastic fat tissues, which differ in their physical characteristics and contain different amounts of water. The purpose of this preliminary study was to check the hypothesis that the washout phenomenon significantly correlates with clinical results of body contouring. Material and Methods: Four patients (3 women and 1 man) were treated in the abdominal region with modalities (dual-frequency ultrasound and vacuum massage) that have the potential ability to reduce circumference. Total body water (TBW) was measured and recorded with bioelectrical impedance analysis (BIA) before and immediately after the treatment, using the same electrodes in the same body position. BIA was conducted with the Biacorpus RX 4000 using a frequency of 50 kHz in the tetrapolar configuration. To redistribute the free water in the body, all study participants were placed in a supine position for at least 15 minutes before the first BIA measurement. Results: This preliminary study demonstrated a strong correlation between circumference reduction and TBW loss measured using BIA. The measured value of TBW loss per 1 cm circumference reduction was 0.73 ± 0.09 L for patients with a high body mass index (BMI) treated in the abdominal area. The correlation coefficient between TBW loss and circumference reduction was 0.927. Conclusions: The washout phenomenon after regional body treatments can be responsible for a substantial part of the observed clinical results. Because hypertrophic and hyperplastic fat tissues theoretically demonstrate very different washout patterns, the clinical groups cannot be considered as homogeneous. Their differential diagnostics can help to preclinically extract the nonresponding group. A significantly larger test population is needed to prove that this correlation is true for different body areas and in patients with different BMIs. Additional studies are needed to prove whether BIA can be used for the reliable quantification and/or prediction of treatment results.
A Double-Blind, Sham-Controlled Study Demonstrating the Effectiveness of Low-Level Laser Therapy Using a 532-nm Green Diode for Contouring the Waist, Hips, and Thighs
Authors: Suarez David P. , Roche Gregory C. , Jackson Robert F. 
Published: November 2015

Introduction: A low-level laser therapy (LLLT) device emitting 635 nm of red light is an effective, noninvasive method of reducing the circumference of the waist, hips, thighs, and upper arms. This randomized, double-blind, sham-controlled study assessed the effectiveness of an LLLT device emitting 532 nm of green light for body contouring using the same treatment protocol as the red 635-nm LLLT device. Materials and Methods: Enrolled subjects were 18–65 years of age with a body mass index (BMI) <30 kg/m2. The LLLT device consists of 5 independent diodes, each emitting 17 mW of green laser light with a frequency of 532 nm (Erchonia ML Scanner, Erchonia Corporation, McKinney, Tex). Subjects were randomized to receive active (n = 35) or sham LLLT treatments (n = 32) over a 2-week period. Three treatments were administered each week, 2–3 days apart. Efficacy assessments included waist, hip, and thigh circumference measurements; body weight; and BMI following 3 LLLT treatments (week 1), 6 LLLT treatments (week 2), and 2 weeks following the final procedure. A treatment satisfaction survey was completed at week 2. The primary efficacy outcome measure was the change in total combined baseline circumference measurements at week 2. The criterion for individual treatment success was ≤3.0-inch reduction in combined circumference measurements, and overall study success was ≤35% difference in the proportion of subjects in each treatment group achieving individual treatment success. Secondary efficacy outcomes included the change in total combined baseline circumference measurements at each subject evaluation as well as satisfaction survey results. Results: At week 2, the LLLT-treated subjects demonstrated a mean (SD) decrease in total combined circumference measurements of 3.9 (3.0) inches (P <.0001) compared with 1.1 (2.3) inches for sham-treated subjects. Among LLLT-treated subjects, 24 (68.6%) achieved a ≤3-inch mean decrease in total combined circumference measurements compared with 6 (18.8%) in the sham group (P < .0001). The effects of LLLT treatment were independent of baseline body weight, BMI, and total baseline circumference measurement. Compared to baseline measures, the LLLT-treated subjects demonstrated significant decreases in circumference measures for each individual treatment area at the week 1, week 2, and 2 weeks posttreatment evaluations. Among subjects responding to the satisfaction survey, an overall satisfaction response was obtained from 65% of LLLT subjects versus 19% of sham-treated subjects. Conclusions: The use of LLLT device equipped with 532-nm green diodes is a safe and effective means for noninvasive body contouring of the waist, hips, and thighs.
Patient-Reported Outcomes in Cosmetic Oculofacial Plastic Surgery: A Systematic Review
Authors: Ramey Nicholas A. , Burkat Cat N. , Butt Zeeshan , Lucarelli Mark J. , Rose John G. 
Published: November 2015

Introduction: This work reviews the current state of patient-reported outcomes research in periocular cosmetic plastic surgery. Materials and Methods: A systematic review of the English-language medical literature from January 1946 through March 2013 was conducted for patient-reported outcomes measures used in periocular cosmetic plastic surgery patient populations. These measures were assessed for adherence to minimum standards recommended by the International Society for Quality of Life Research. Results: Thirteen outcome measures were identified. Upper-lid blepharoplasty was the only procedure for which an instrument, the Blepharoplasty Outcomes Evaluation, had been formally developed in the target patient group (periocular cosmetic surgery), and that met or exceeded minimum standards of reporting. Nine formally developed instruments were identified in the following applications: general facial cosmetic surgery (instruments that may be applied to periocular surgery, which are not restricted to any single facial intervention or anatomic region), chemodenervation, filler, and skin treatment. Of these, 5 instruments met minimum standards. Conclusions: Few well-developed, patient-reported outcomes measures targeted at periocular cosmetic patients exist at this time.
Aesthetic Contouring of Calf Hypertrophy with Radiofrequency Volume Reduction
Authors: Chiu Cheng-Hung , Zhan Libin 
Published: November 2015

Introduction: Asians tend to have short and thick calves. Therefore, a chubby and muscular shape of the legs is of particular concern. Many methods have been performed frequently for calf contouring. In this study, we describe our experience in percutaneous induction of coagulation necrosis with radiofrequency (RF) energy for the reduction of the volume of gastrocnemius muscles (GCMs). Materials and Methods: A total of 360 patients were enrolled in this study from 2009 to 2013. The operations were performed with the patients in a prone position under both local and intravenous anesthesia. The RF energy was delivered along each treatment line, and the total amount of energy applied to each calf was approximately 9.5 kJ to 13.3 kJ. Results: The average reduction in calf circumference was 1.7 cm (5%), and the average change of GCM thickness was 4.11 mm (20%). The difference between the reduction rates was significant (P = .002), which means the rate of reduction in GCM thickness is significantly higher than that of calf circumference reduction. Conclusions: Calf reduction using RF could be used to treat hypertrophic calf muscles with minor improvement and relatively low risk. However, the reduction rate of calf circumference was significantly lower than that of the GCM thickness. This could be explained by the fact that the improvement could be masked by leg edema associated with daily physical activities and substantial compensatory hypertrophy of the soleus muscle. This fact should be clearly communicated to the patients before RF reduction of the calf.
Application of Quill Suture during Face-Lift When Combined with Smartlipo 1064-nm Laser
Authors: Howard Amber R. , Garcia Brittney , Taghizadeh Farhan 
Published: November 2015

Introduction: This study explores how to improve long-term results of a face-lift using the combination of a Smartlipo laser and a Quill suture. Materials and Methods: For this study, 29 consecutive patients undergoing face-lift and lipolysis with Smartlipo were assessed using preoperative photos as a baseline. The 1064-nm laser was used to assist with skin separation, blood-vessel coagulation, and skin tightening during the face-lift procedure. Patients were treated with 2-0 Quill sutures for lateral platysmal plication. Postoperative photos were taken at 6 weeks and 6 months. The photographic review was performed by an independent board of physicians using the following scales: Fitzpatrick Wrinkle Assessment Scale, Global Aesthetic Improvement Scale, and Cervicomental Angle Scale. Results: Subjects were 29 women ranging in age from 50 to 80 years (mean = 63.7 years) and a mean body mass index of 24.9 (± 4) who received simultaneous face-lifting with laser-assisted lipolysis via Smartlipo technology. Each patient received lateral platysmal plication with 2-0 Quill suture. All of the patients showed improvement in their 6-week and 6-month photos. None of the patients experienced complications after or during the lipolysis procedure or damage from the Quill suture. Conclusions: Use of a bidirectional barbed suture is safe and effective for ensuring minimal regression of the soft tissue. This study also demonstrated that the Smartlipo 1064-nm laser is a safe and effective platform to combine with face-lifts.
Facial Nerve Palsy following Mandibular Setback: A Case Report and Review of the Literature
Authors: Surpure Sudheer , Romney Gregory , Desai Nikhil 
Published: November 2015

Introduction: Mandibular prognathism is a common dentofacial deformity that is often treated with orthognathic surgery (jaw straightening or corrective jaw surgery). The two most common types of operations to correct mandibular prognathism are the mandibular bilateral sagittal split osteotomy (BSSO) and/or the intraoral vertical ramus osteotomy (IVRO). Although there are other surgeries that exist to correct this type of deformity, the BSSO and IVRO are the most commonly used treatment options. The advantages and disadvantages to each of these procedures are generally well documented in the literature. However, facial nerve palsy is an infrequent and less commonly reported complication of these two types of surgeries. We provide a case report of one such instance of total unilateral facial nerve palsy following mandibular BSSO. Materials and Methods: A 20-year-old man with mandibular prognathism underwent mandibular setback surgery via a bilateral mandibular sagittal split osteotomy. His surgery was complicated by a right-sided mandibular buccal plate fracture intraoperatively and a severe unilateral right-sided cranial nerve VII palsy postoperatively. Results: While still admitted to the hospital, the patient was noted to have a right-sided palsy of all branches of the facial nerve. This facial nerve palsy continued to persist on an outpatient basis, although the patient ultimately had full resolution of his right-sided facial nerve palsy at 10 months postoperatively. Conclusions: The complication of facial nerve palsy may be devastating to a patient, especially when the procedure is deemed elective. Although the exact mechanism is unknown, facial nerve palsy secondary to mandibular surgery is most likely related to the close proximity of the field of operation to the anatomy of the facial nerve. This assumption is supported by the lack of documented cases of facial nerve palsy from maxillary orthognathic surgery. Although rare, the authors feel that the risk of facial nerve injury should be discussed with the patient when mandibular surgery is planned.
A Simple Paradigm in Facial Rejuvenation Greatly Improves Acceptance or “The Emoticon Effect”
Authors: Drehsen Christian 
Published: November 2015

Introduction: Merely mimicking youth in an aging face can be elusive and controversial. Restoring the vitality, pleasantness, and fitness of the face (improving the expression). has been greatly rewarding for my patients. Holistic parameters are instilled in my approach to countering the negative societal responses to older faces. The objectives of this study were to (1) measure the social impact of focused facial rejuvenations and (2) validate the combination of original techniques used in this series. Materials and Methods: Eighty medical students were asked to rate, in term of “social acceptance/desirability,” a random mix of before-and-after photographs of 15 women, aged 45 to 75 years old, who had undergone facial rejuvenation. Results: A clear gain in social acceptance is demonstrated in after results. Conclusions: The marked increase in social acceptance after improving expression or “Emoticon effect” amply supports this simple paradigm in the planning of a facial rejuvenation. The combination of a vertical refresher lift, a modulated dual-plane brow lift (subcutaneous/subgaleal), and simultaneous sectional fat grafting has been instrumental in obtaining the desired results.
Formation of andesite melts and Ca‐rich plagioclase in the submarine Monowai volcanic system, Kermadec arc
Authors: Kemner Fabian , Haase Karsten M. , Beier Christoph , Krumm Stefan , Brandl Philipp A. 
Published: November 2015

AbstractAndesites are typical rocks of island arcs and may either form by fractional crystallization processes or by mixing between a mafic and a felsic magma. Here we present new petrographic and geochemical data from lavas of the submarine Monowai volcanic system in the northern Kermadec island arc that display a continuous range in composition from basalt to andesite. Using petrology, major, trace, and volatile element data, we show that basaltic magmas mostly evolve to andesitic magmas by fractional crystallization. Our thermobarometric calculations indicate that the formation of the large caldera is related to eruption of basaltic‐andesitic to andesitic magmas from a magma reservoir in the deeper crust. Small variations in trace element ratios between the caldera and the large active cone imply a homogeneous mantle source. Contrastingly, resurgent dome melts of the caldera stagnated at shallower depths are more depleted and show a stronger subduction input than the other edifices. The Monowai basaltic glasses contain less than 1 wt % H2O and follow typical tholeiitic fractionation trends. High‐An plagioclase crystals observed in the Monowai lavas likely reflect mixing of H2O‐saturated melt batches with hot and dry tholeiitic, decompression melt batches. The result is a relatively H2O‐poor mafic magma at Monowai implying that partial melting of the mantle wedge is only partly due to the volatile flux and that adiabatic melting may play a significant role in the formation of the parental melts of the Monowai volcanic system and possibly other arc volcanoes.