bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Outcomes of DSAEK in Patients with Prior Ahmed Glaucoma Drainage Device Placement
Authors: Schoenberg Evan D. , Levin Ken H. , Savetsky Michael J. , Mcintire Lisa U. , Ayyala Ramesh S. 
Published: July 2013

Purpose To study the surgical outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) in eyes with previous Ahmed glaucoma valve (AGV) implantation. Methods Retrospective chart review of all patients who underwent DSAEK by a single surgeon in the setting of prior AGV implantation between December 2009 and September 2011 with at least 12 months follow-up. Preoperative and postoperative endothelial cell counts, visual acuity, intraocular pressure, and glaucoma medications were recorded. Results Eighteen eyes of 13 patients were included. The average endothelial cell count (cells/mm2) was 3087.7 (SD 390.8) preoperatively, 1974.3 (SD 646.0) at 6 months, 1831.7 (SD 851.2) at 12 months, and 1821.3 (SD 762.2) at 24 months. The average IOP (mm Hg) was 13.7 (SD 4.3) preoperatively, 15.1 (SD 5.0) at 6 months, 15.5 (SD 6.6) at 12 months, and 15.1 (SD 4.8) at 24 months. Average visual acuity (VA) preoperatively was 20/100 (logMAR 0.73, SD 0.27) and average best VA postoperatively was 20/60 (logMAR 0.5, SD 0.27). Nine of the 18 eyes (50%) had failed DSAEK grafts at 9.3 (SD 6.0) months. Six of these eyes had peripheral anterior synechiae (PAS) preoperatively, 3 had a history of uveitis, and 4 failures had multiple AGVs. Intraocular pressure control (<21 mm Hg) was maintained without additional medications in 11 eyes (61%) and with additional medication in 4 eyes (22%). Intraocular pressure control was not maintained in 3 eyes (17%). Conclusions Though challenging, DSAEK surgery can be successful in the setting of previous AGV implantation, with success rates comparable to those of penetrating keratoplasty in the same population. Higher failure rate of DSAEK with prior AGV appears to be associated with the presence of chronic angle closure glaucoma with 360-degree PAS with shallow chambers, the presence of multiple AGVs, and presence of uveitis.
The Role of Intraoperative Bevacizumab for Prevention of Postoperative Vitreous Hemorrhage in Diabetic Vitreous Hemorrhage
Authors: Göncü Tuğba , Özdek Şengül , Ünlü Metin 
Published: July 2013

Purpose To assess the effect of intravitreal bevacizumab (IVB) on the incidence of postoperative recurrent vitreous hemorrhage (VH) in eyes operated for diabetic VH when injected at the end of the surgery. Methods A prospective, comparative clinical trial was conducted on a consecutive series of patients requiring vitrectomy for diabetic nonclearing VH. Intravitreal bevacizumab (2.5 mg/0.1 mL) was injected at the completion of surgery. Patients underwent best-corrected visual acuity (VA), applanation tonometry, and biomicroscopic anterior and posterior segment evaluation for VH grading. Postoperative visits were performed at the first day, first week, first month, third month, and sixth month. The VH was graded at each visit, and the rate of postoperative VH and VA improvement and potential complications were evaluated and compared between the groups. Results A total of 72 eyes of 66 patients were included. Thirty-four eyes were enrolled in the IVB group and 38 eyes were enrolled in the control group. The rate of postoperative VH did not differ significantly between the groups at any postoperative visit (p>0.05). Three eyes (8.8%) in the IVB group and 5 eyes (13.1%) in the control group had postoperative VH throughout the follow-up period and only one eye from each group underwent a second surgery. Postoperative VA significantly increased in both groups but did not differ significantly between the groups at any postoperative visit (p>0.05). Conclusions Intravitreal bevacizumab does not seem to have any beneficial effect on the incidence of postoperative VH in eyes operated for diabetic VH when injected at the end of surgery.
Clinical Analysis of Macular Edema with New Software for SD-OCT Imaging
Authors: Azzolini Claudio , Sansoni Giovanna , Donati Simone , Parodi Maurizio Battaglia , Oum Muna Al , Vinciguerra Riccardo , Tartaglia Valerio , Semeraro Francesco , Virgili Gianni 
Published: July 2013

Purpose To evaluate the clinical efficacy of user-friendly software for the measurement of intraretinal hyporeflective spaces expression of macular edema. Methods Fifteen consecutive patients with diabetic retinopathy with clinically significant macular edema were examined using conventional spectral domain optical coherence tomography (OCT). A new composite software application, OCT–measurement analysis tool (OCT-MAT), was developed to automatically process and analyze OCT B-scans by means of image acquisition, filtering, and elaboration, together with hyporeflective area recognition and measurement in μm2. The same macular areas were measured manually, and then compared to the measurements obtained by the automated OCT-MAT software. A statistical t test analysis was applied (statistical significance level at p<0.05). The repeatability and reproducibility coefficient for the automated software was computed using the Wilcoxon matched pair test (5% significance level). Results In all patients, the software effectively measured the number and extension of intraretinal hyporeflective spaces in μm2. The comparison between mean manual measurements and OCT-MAT measurements (0.478 ± 0.300 × 106 μm2 vs 0.471 ± 0.321 × 106 μm2) showed correct correspondence (p>0.05). Moreover, the OCT-MAT software showed good repeatability and reproducibility (coefficient below 3%). Conclusions OCT-MAT allows the precise measurement of macular edema in terms of the number of empty spaces and their size in all patients. Its daily clinical application might give precise information regarding the evolution of macular edema and the efficacy of therapy.
Presumed Herpetic Anterior Uveitis: A Study with Retrospective Analysis of 79 Cases
Authors: Nalcacioglu-Yüksekkaya Pinar , Ozdal Pinar C. , Teke Mehmet Yasin , Kara Caner , Ozturk Faruk 
Published: July 2013

Purpose To describe the clinical features, visual outcome, medical treatment, and complications of presumed herpetic anterior uveitis. Methods We retrospectively analyzed the clinical data related to 79 eyes of 77 patients with presumed herpetic anterior uveitis seen at the Uveitis Unit of the Ulucanlar Eye Training and Research Hospital from 1996 to 2011. Age at onset of disease, sex, follow-up duration, existence of corneal involvement, posterior synechiae, distorted pupil, iris atrophy, characteristic of keratic precipitates, elevated intraocular pressure (IOP), medical treatment, recurrence rate, complications, visual acuities (VA), and surgery for complications were recorded. The complication rates in patients with and without corneal involvement were compared. Results There were 38 (49.4%) female and 39 (50.6%) male patients. The mean age at presentation was 48.5 ± 14.8 (20–82) years. The follow-up period was 26.5 (2–127) months. Two patients had bilateral involvement. Ocular findings were a corneal scar or active keratitis in 37 (46.8%) eyes, secondary glaucoma in 14 (17.7%), iris atrophy in 39 (49.4%), distorted pupil in 16 (20.3%), posterior synechiae in 23 (29.1%), and granulomatous anterior uveitis in 30 (40%) eyes. Eight (10.1%) eyes had a posterior subcapsular cataract. Glaucoma surgery was required for uncontrolled IOP with maximum medical treatment in 2 (2.4%) eyes. Long-term oral acyclovir was used in 9 (11.3%) patients. Final VA was ≤ 0.1 in 8 (10.1%) eyes; of these, 6 had either corneal scarring or cataract and 2 preexisting amblyopia. Conclusions Presumed herpetic anterior uveitis with or without keratitis has characteristic clinical findings that enable the diagnosis. Long-term prophylactic antiviral therapy should be considered especially in patients <50 years old.
Comparison of Far and near Contrast Sensitivity in Patients Symmetrically Implanted with Multifocal and Monofocal Iols
Authors: Gil Miguel A. , Varón Consuelo , Cardona Genís , Vega Fidel , Buil José A. 
Published: July 2013

Purpose A prospective, randomized, double-masked, clinical trial was designed to evaluate distance and near contrast sensitivity (CS) in patients symmetrically, and randomly, implanted with 4 different multifocal intraocular lens (MIOL) designs (ReSTOR SN6AD1, ReSTOR SN60D3, ReZoom NXG, and Tecnis ZMA00) and a monofocal control group (Tecnis ZA9003), 6 months after cataract intervention. Methods Photopic, mesopic, and mesopic with glare distance CS, as well as photopic near CS, was evaluated with the CSV-1000 CS test and the Vistech VCTS 6000 system, respectively, in a group of 180 patients attending the ophthalmology department of Sant Pau Hospital, Barcelona, for cataract intervention and lens implantation. Results Statistically and clinically significant differences were found between the monofocal and multifocal lens groups at all spatial frequencies and illumination conditions, both during distance and near CS evaluation (all p<0.05), with the monofocal lens offering the best performance in all cases. Contrast sensitivity was similarly compromised in all MIOL models at distance, although MIOLs with diffractive optics and aspheric profiles showed a non–statistically significant trend to perform better in mesopic conditions. Near CS was lower for refractive, distance dominant lens designs, particularly at medium to high spatial frequencies. Conclusions The present results, which reflect intraocular lens (IOL) characteristics in optics, profile, and add power, may contribute to help surgeons decide on the type of IOL most suitable for each patient by taking into consideration the individual needs for critical distance and near vision, both in terms of visual acuity and contrast sensitivity.
Intermediate Uveitis: Comparison between Childhood-Onset and Adult-Onset Disease
Authors: Paroli Maria Pia , Abicca Irene , Sapia Alfredo , Bruschi Simone , Pezzi Paola Pivetti 
Published: July 2013

Purpose To compare demographic and clinical data, systemic disease association, visual prognosis, and complications found in childhood and adult onset of intermediate uveitis (IU). Methods Retrospective cohort study of 287 patients with IU: 122 (42.5%) children at onset (<16 years), 165 (57.5%) adults. The data were entered on a computer-based standardized data entry form for statistical analysis. Student t test was used regarding differences in means. To assess significance of differences in proportions, we used the χ 2 test, but when the population in the subgroup was ≤5 patients, we used the Fisher exact test (p<0.05 were deemed to be statistically significant and as reported were not corrected for multiple testing and so should be viewed as nominal). Results A total of 61% of childhood-onset cases occurred in boys (44% in the adult group), while adult onset was more common in women (56% vs 39%) (p = 0.004, odds ratio [OR] 2.06). Regardless of the onset age, IU was frequently bilateral and idiopathic. The most frequent complication was cystoid macular edema (27.5%, p = 0.469, OR 0.85), which was also the most frequent cause of visual loss. Optic disc edema was more prevalent in children (15.5% vs 9.2%; p = 0.027, OR 1.81), ocular hypertension in adults (15.6% vs 7.5%, p = 0.007, OR 0.44). A total of 25 patients had non-idiopathic IU. A total of 14 patients had multiple sclerosis. Conclusions Intermediate uveitis was mostly idiopathic and bilateral in both groups. Visual prognosis was good and it was not age-related. Childhood onset was more frequent in boys, adult onset in women. Endocrinal factors could be involved.
Intravitreal Ranibizumab for Myopic Choroidal Neovascularization after Pars Plana Vitrectomy and Silicone Oil Tamponade
Authors: Cascavilla Maria Lucia , Querques Giuseppe , Querques Lea , Codenotti Marco , Bandello Francesco 
Published: July 2013

Purpose To report on intravitreal Ranibizumab for intervening myopic choroidal neovascularization (CNV) in a case of retinal detachment successfully repaired with pars plana vitrectomy and silicone oil tamponade. Methods Intravitreal ranibizumab was performed in a 67-year-old woman with CNV complicating pathologic myopia. The patient had previously undergone vitrectomy and silicone oil tamponade for retinal detachment. Results At 2 months from intravitreal ranibizumab, best-corrected visual acuity (BCVA) improved from count fingers to 20/100, and intraocular pressure (IOP) was 16 mm Hg. Fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT) showed resolution of late leakage and subretinal/intraretinal fluid, respectively. Conclusions Administration of intravitreal anti-VEGF in patients with silicone oil as intraocular tamponade may represent an intriguing treatment option. Our results suggest that intravitreal injections of Ranibizumab may lead to a rapid improvement in both functional (BCVA) and morphologic (FA and SD-OCT) parameters of CNV activity, without significant rise in IOP, in eyes with silicone oil as intraocular tamponade.
Effects of Levodopa on Retina in Parkinson Disease
Authors: Sen Aysu , Tugcu Betul , Coskun Cigdem , Ekinci Cansu , Nacaroglu Senay Asik 
Published: July 2013

Purpose To evaluate the effects of levodopa on retina, we assessed retina with optical coherence tomography (OCT) in Parkinson disease (PD). Methods Thirty-five patients with PD (17 with levodopa monotherapy, 18 untreated) and 11 healthy controls were included in this cross-sectional study. Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn & Yahr (H&Y) staging scale were used for the evaluation of disease severity. All retinal scans were performed using OCT. Results Total UPDRS and motor subscores were lower in untreated patients compared to patients with treated PD (p = 0.013, p = 0.033, respectively). There was no significant difference in the range of H&Y stages between the untreated and treated PD groups (p = 0.342). The average retinal nerve fiber layer thickness of the untreated (106.76 ± 10.55 μm) and treated (104.62 ± 8.23 μm) patients with PD were significantly thinner than those of controls (115.60 ± 9.11 μm) (p<0.005). However, there was no significant difference between the untreated and patients with treated PD (p = 0.780). No significant difference in mean values of average thickness of ganglion cell complex layer was observed among controls, patients with untreated PD, and patients with treated PD (p = 0.304). Conclusions Although the disease in patients with treated PD was more severe than in the untreated group, no significant difference in the thickness of retina was found between the 2 groups. Therefore, we thought that levodopa might have a protective effect on retina in patients with PD.
Mean Platelet Volume in Pseudoexfoliation Syndrome and Glaucoma
Authors: Türkcü Fatih Mehmet , Yüksel Harun , Şahin Alparslan , Cinar Yasin , HaticeYüksel  , Cingü Kürşat , Şahin Muhammed , Yildirim Adnan , Çaça Ihsan 
Published: July 2013

Purpose Pseudoexfoliation (PEX) syndrome (PES) is characterized by the widespread deposition of abnormal extracellular fibrillary material on many ocular and extraocular tissues. The objective of this study was to evaluate the association among PES, PEX glaucoma (PEG), and mean platelet volume (MPV). Methods Forty patients with PES (mean age 62.6 ± 7.8 years), 31 with PEG (mean age 65.9 ± 6.6 years), and 37 healthy individuals (control group) (mean age 64.0 ± 7.1 years) were included in the study. The MPV of the 3 groups were compared. Results Age and sex distribution were similar among groups (p>0.05). Mean MPV in PES, PEG, and control groups were 9.59 ± 0.94 fl, 9.53 ± 0.80 fl, and 7.7 ± 0.67 fl, respectively. In the PEX group, MPV values were significantly higher than in the control group (p<0.05). However, there was no difference between the PES and PEG groups (p>0.05). Conclusions The MPV values in both groups with PEX were higher than those in the healthy group.
High-Resolution, 2- and 3-Dimensional Imaging of Uncut, Unembedded Tissue Biopsy Samples
Authors: Torres Richard , Vesuna Sam , Levene Michael J. 
Published: July 2013

Context.—Despite continuing advances in tissue processing automation, traditional embedding, cutting, and staining methods limit our ability for rapid, comprehensive visual examination. These limitations are particularly relevant to biopsies for which immediate therapeutic decisions are most necessary, faster feedback to the patient is desired, and preservation of tissue for ancillary studies is most important. The recent development of improved tissue clearing techniques has made it possible to consider use of multiphoton microscopy (MPM) tools in clinical settings, which could address difficulties of established methods.
Objective.—To demonstrate the potential of MPM of cleared tissue for the evaluation of unembedded and uncut pathology samples.
Design.—Human prostate, liver, breast, and kidney specimens were fixed and dehydrated by using traditional histologic techniques, with or without incorporation of nucleic acid fluorescent stains into dehydration steps. A benzyl alcohol/benzyl benzoate clearing protocol was substituted for xylene. Multiphoton microscopy was performed on a home-built system.
Results.—Excellent morphologic detail was achievable with MPM at depths greater than 500 μm. Pseudocoloring produced images analogous to hematoxylin-eosin–stained images. Concurrent second-harmonic generation detection allowed mapping of collagen. Subsequent traditional section staining with hematoxylin-eosin did not reveal any detrimental morphologic effects. Sample immunostains on renal tissue showed preservation of normal reactivity. Complete reconstructions of 1-mm cubic samples elucidated 3-dimensional architectural organization.
Conclusions.—Multiphoton microscopy on cleared, unembedded, uncut biopsy specimens shows potential as a practical clinical tool with significant advantages over traditional histology while maintaining compatibility with gold standard techniques. Further investigation to address remaining implementation barriers is warranted.
Spatial Control of Condensation and Freezing on Superhydrophobic Surfaces with Hydrophilic Patches
Authors: Mishchenko Lidiya , Khan Mughees , Aizenberg Joanna , Hatton Benjamin D. 
Published: July 2013

AbstractCertain natural organisms use micro‐patterned surface chemistry, or ice‐nucleating species, to control water condensation and ice nucleation for survival under extreme conditions. As an analogy to these biological approaches, it is shown that functionalized, hydrophilic polymers and particles deposited on the tips of superhydrophobic posts induce precise topographical control over water condensation and freezing at the micrometer scale. A bottom‐up deposition process is used to take advantage of the limited contact area of a non‐wetting aqueous solution on a superhydrophobic surface. Hydrophilic polymer deposition on the tips of these geometrical structures allows spatial control over the nucleation, growth, and coalescence of micrometer‐scale water droplets. The hydrophilic tips nucleate water droplets with extremely uniform nucleation and growth rates, uniform sizes, an increased stability against coalescence, and asymmetric droplet morphologies. Control of freezing behavior is also demonstrated via deposition of ice‐nucleating AgI nanoparticles on the tips of these structures. This combination of the hydrophilic polymer and AgI particles on the tips was used to achieve templating of ice nucleation at the micrometer scale. Preliminary results indicate that control over ice crystal size, spatial symmetry, and position might be possible with this method. This type of approach can serve as a platform for systematically analyzing micrometer‐scale condensation and freezing phenomena, and as a model for natural systems.
Structure‐Controlled, Vertical Graphene‐Based, Binder‐Free Electrodes from Plasma‐Reformed Butter Enhance Supercapacitor Performance
Authors: Seo Dong Han , Han Zhao Jun , Kumar Shailesh , Ostrikov Kostya (Ken) 
Published: July 2013

AbstractVertical graphene nanosheets (VGNS) hold great promise for high‐performance supercapacitors owing to their excellent electrical transport property, large surface area and in particular, an inherent three‐dimensional, open network structure. However, it remains challenging to materialise the VGNS‐based supercapacitors due to their poor specific capacitance, high temperature processing, poor binding to electrode support materials, uncontrollable microstructure, and non‐cost effective way of fabrication. Here we use a single‐step, fast, scalable, and environmentally‐benign plasma‐enabled method to fabricate VGNS using cheap and spreadable natural fatty precursor butter, and demonstrate the controllability over the degree of graphitization and the density of VGNS edge planes. Our VGNS employed as binder‐free supercapacitor electrodes exhibit high specific capacitance up to 230 F g−1 at a scan rate of 10 mV s−1 and >99% capacitance retention after 1,500 charge‐discharge cycles at a high current density, when the optimum combination of graphitic structure and edge plane effects is utilised. The energy storage performance can be further enhanced by forming stable hybrid MnO2/VGNS nano‐architectures which synergistically combine the advantages from both VGNS and MnO2. This deterministic and plasma‐unique way of fabricating VGNS may open a new avenue for producing functional nanomaterials for advanced energy storage devices.
Exudative retinopathy, cerebral calcifications, duodenal atresia, preaxial polydactyly, micropenis, microcephaly and short stature: A new syndrome?
Authors: Isidor Bertrand , Le Meur Guylène , Conti Carole , Caldagues Emmanuelle , Lainey Elodie , Launay Elise , Leclair Marc David , Le Francois Thomas , Pichon Olivier , Boisseau Pierre , Migraine Audrey , Keren Boris , Caignec Cédric Le , Crow Yanick J , David Albert 
Published: July 2013

AbstractThe association of Coats disease with intrauterine growth retardation, intracranial calcification, leukodystrophy, brain cysts, osteopenia, and gastrointestinal bleeding defines Coats plus syndrome caused by mutations in the CTC1 gene, encoding conserved telomere maintenance component 1. Here, we report on a child with exudative retinopathy, cerebral calcifications, duodenal atresia, preaxial polydactyly, micropenis, microcephaly, and short stature, in whom no mutations in CTC1 were found. Our patient shares some features seen in other diseases associated with telomere shortening including Hoyeraal–Hreidarsson and Revesz syndromes. We therefore measured telomere length by Flow‐Fish which was normal. The association of duodenal atresia and microcephaly also suggested a diagnosis of Feingold syndrome. However, direct sequencing of MYCN was normal, and we did not detect any hemizygous deletion of the miR‐17∼92 polycistronic miRNA cluster. To our knowledge, the phenotype we report on has not been described previously, leading us to speculate that this condition may represent a new syndrome. © 2013 Wiley Periodicals, Inc.