bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloid-derived suppressor cells in axial spondyloarthritis patients with different types of therapy
Authors: Morenkova A. Yu. , Tyrinova T. V. , Fedorova A. V. , Tikhonova M. A. , Ilina N. A. , Chumasova O. A. , Sizikov A. E. , Chernykh E. R. 
Published: June 2024

Aim – to evaluate myeloid-derived suppressor cell (MDSC) subset counts and their suppressor potential in axial spondyloarthritis (axSpA) patients, as well as to analyze changes in the studied parameters in biological therapy (BT).Materials and methods. The study included 50 axSpA patients receiving 1st line therapy (non-steroidal anti-inflammatory drugs ±sulfasalazine/methotrexate) and 44 ageand sex-related healthy donors. Eight patients were initiated with BT (TNFαor IL-17 inhibitors). Peripheral blood granulocytic (G-MDSC), monocytic (M-MDSC) MDSCs, early-stage differentiation MDSCs (E-MDSC), and inhibitory molecule expression (PDL1, Arg-1, and IDO) were evaluated by flow cytometry.Results. The axSpA patients were characterized by increased G-MDSC counts (р<0.01), particularly manifested with high disease activity. Axial manifestation was associated with a combination of increased G-MDSC and E-MDSC numbers (р<0.05). The extra-axial group showed an isolated increase in G-MDSC (р<0.05), whereas coxitis was associated with an increase in both G-MDSC and M-MDSC (р<0.05). Low activity was associated with an isolated M-MDSC increase (р=0.045). Patients had reduced expression of majority of the studied suppressor molecules in MDSCs. Axial manifestation was characterized by a decreased expression of PDL1 and IDO in G-MDSCs and E-MDSCs (р<0.05), as well as Arg-1 in E-MDSCs and M-MDSCs (р<0.05). Patients with extra-axial manifestations (including coxitis) exhibited the most significant reduction in the expression of all three inhibitory molecules in M-MDSCs. High activity was associated with a decrease in PDL1+ G-MDSCs and E-MDSCs (р<0.05), as well as Arg-1and IDO-expressing M-MDSCs (р<0.05). In low disease activity, most of the analyzed parameters did not differ significantly from donor values, with the exception of a reduced Arg-1+ M-MDSC frequency (р=0.04). BT reduced G-MDSC counts in 75% of patients to levels comparable to those of healthy donors.Conclusion. Despite the reduced suppressor potential of MDSCs, patients undergoing first-line therapy with high activity demonstrated increased G-MDSC counts, while low activity axSpA was characterized by an isolated increase in M-MDSCs. The BT administration blocked G-MDSC accumulation.
Factores psicosociales y síndrome de Burnout en docentes universitarios de Ciencias de la Salud
Authors: Martin Bogdanovich María Mini , Agüero Corzo Eucaris del Carmen , Dávila Morán Roberto Carlos 
Published: June 2024

La labor docente es esencial en la educación y formación de las generaciones futuras. Estos influyen en el desarrollo de los estudiantes y les proporcionan las herramientas necesarias para alcanzar su potencial máximo. No obstante, enfrentan factores psicosociales que pueden afectar tanto su bienestar emocional como la calidad de su enseñanza. El objetivo de este artículo es Determinar la relación entre los factores psicosociales y el síndrome de Burnout en docentes de Ciencias de la Salud de una universidad privada en Lima, Perú. La metodología responde al enfoque cuantitativo, diseño no experimental de tipo transversal, correlacional. Participaron 132 profesores de la Facultad de Ciencias de la Salud de una universidad privada en Lima, Perú; mediante el muestreo no probabilístico. Se aplicaron: el “Cuestionario de Factores Psicosociales en el Entorno Académico” y el “Cuestionario Revisado de Burnout en Profesores”. En los resultados se reportó un nivel medio en factores psicosociales con 50,00%, sin embargo, en la dimensión carga de trabajo, se registró un nivel alto, con un 51,52%. También se identificó un nivel medio con 43,94% en la variable síndrome de Burnout. Sin embargo, en cansancio emocional, se observó un nivel alto, con un 49,24%. En conclusión, se determinó que existe relación entre los factores psicosociales y el síndrome de Burnout, con rho = 0,328 y p-valor = 0,000 < 0,05. Esto indica que hay una relación directa y de baja magnitud entre estos dos aspectos.
Mecanismos de autentificación para el acceso del recurso humano-docente a las infraestructuras tecnológicas y redes de computadoras en el C.R.U de Veraguas
Authors: Rodríguez C. Oscar E. , Dutari D. Raúl E. , Rodríguez F. David A. , Fernández G. Libertad , Quintero P. Juan G. , Chang M. Humberto J. 
Published: June 2024

Con el propósito de identificar las fortalezas y debilidades de los mecanismos de autentificación para el acceso a las infraestructuras tecnológicas que se administran y gestionan bajo el entorno de las redes de computadoras en el Centro Regional Universitario de Veraguas, se aplicó durante los meses de noviembre-diciembre del año 2023, un formulario en línea dirigido de manera remota y con el consentimiento informado, a 373 profesores que forman las 16 facultades en esta unidad académica. El 79.08% (295) respondieron dicho instrumento, el cual recopiló el promedio de los años de servicios académicos y la dedicación docente como elementos generales; y como aspecto concluyente, se determinó que el 93.22% (275) considera muy importante la capacitación técnica del recurso humano-docente, en materia de seguridad para el diseño de contraseñas para el acceso a las infraestructuras tecnológicas y de la aplicación de nuevas políticas de protección de la información para la mejor administración de los métodos de autentificación en el uso de las redes de computadoras.
Design for disassembly and cultural sites. The use of modular architecture and prefabrication in exhibition venues
Authors: Resta Giuseppe , Gonçalves Samuel 
Published: June 2024

The article discusses the use of modular architecture and prefabrication in exhibition venues, looking at the possibility of designing installations with multiple temporalities. Through four concrete experimentations, we discuss ways of repurposing precast modules in new layouts with different functional programs in line with the “design for disassembly” concept. The article also emphasises the relevance of the massive residential construction programme based on modular and prefabricated systems launched by the German Democratic Republic in the mid-1970s, and the importance of reducing the environmental impact of concrete production today. Moreover, aiming at the need to devise new strategies, it presents a research agenda towards the adoption of prefabricated modules or the cultural sector. The four cases presented here are derived from the experimental use of modular solutions by the Porto-based practice SUMMARY: the GOMOS system indicates that prefabricated modules may have a longer lifespan than traditional building layouts, as they can be repurposed, making their reuse economically viable and environmentally friendly; the “Infrastructure-Structure-Architecture” installation at La Biennale 2016 reflects on possible adjustments in the construction industry; the project for the 2018 YAP MAXXI showcases the design process of a temporary installation that becomes a permanent building; and the VR exhibition “The Reasons Offsite” addresses prefabrication as a portable dissemination project.
An Overview of Sports-Mediated Brain Injuries and Its Management Ap-proaches: A Narrative Review
Authors: Grover Parul , Nobari Hadi , Bhardwaj Monika , Mehta Lovekesh , Kapoor Garima , Chawla Pooja A. , Paolo Ardigò Luca 
Published: June 2024

PurposeThe objective of the present study was to provide an update on the 16 sports with the highest incidence of brain injuries. Thereafter, its diagnosis, treatment, and management strategies are discussed.MethodsThe manuscript addresses the brain-related injuries individually in each of the 16 sports with the highest incidence. To simplify the reading, the mentioned 16 sports are sorted alphabetically. A subpart mentioning the management of brainrelated sports injuries, including pharmacological management, is also included in the manuscript.ResultsThe incidence of sports-mediated brain injuries within hospital-based studies ranged between 3.5 and 31.5 per 100,000. One community-based study using multiple case ascertainment sources identified a higher incidence of 170 per 100,000. Brain injuries due to sports total 1.2–30.3% of all TBIs (traumatic brain injuries). Men have a higher prevalence than women (75.6% vs. 66.1%), and adolescents and young adults had the highest incidence of sports-mediated brain injuries. Almost 50% of head injuries reported during the practice of sports or recreational activities occur in bicycling, skateboarding, or skating incidents. More than 775,000 children, aged 14 and younger, are treated yearly in hospital emergency rooms for sports-related injuries.ConclusionsBrain injuries are common in sports and difficult to manage, but athlete health and injury prevention should be the priority. Preventive measures should be stricter in sports with a higher incidence of brain injury. As for treatment, a comprehensive approach should be adopted.
Review article: Feature tracing in radio-echo sounding products of terrestrial ice sheets and planetary bodies
Authors: Moqadam Hameed , Eisen Olaf 
Published: June 2024

Abstract. Radio-echo sounding (RES) is a useful technique for measuring the subsurface properties of ice sheets and glaciers. One of the most important and unique outcomes is the mapping of ice sheets' englacial layer stratigraphy, mainly consisting of isochronous reflection horizons. Mapping those is still a labour-intensive task. This review provides an overview of state-of-the art (semi-)automated methods for identifying ice surface, basal, and internal reflection horizons from radargrams in radioglaciology. We discuss a variety of methods which were developed or applied to RES data over the last decades, including image processing, statistical techniques, and deep learning approaches. For each approach, we briefly summarize their procedures, challenges, and potential applications. Despite major advances, we conclude that gaps remain in effectively mapping internal reflection horizons in an automated way, but with deep learning representing a potential advancement. This paper aims to inform researchers and practitioners in radioglaciology about current and future trends in mapping the englacial stratigraphy of ice sheets.
Mapping geochemical anomalies by accounting for the uncertainty of mineralization-related elemental associations
Authors: Wang Jian , Zuo Renguang , Liu Qinghai 
Published: June 2024

Abstract. Geochemical mapping is a fundamental tool for elucidating the distribution and behaviour of economically significant elements and providing valuable insights into geological processes. Nevertheless, the quantification of uncertainty associated with geochemical mapping has only recently become a subject of widespread concern. This study presents a procedure that primarily consists of the determination of homogeneous clusters, the recognition of elemental associations for each cluster, and the identification of geochemical anomalies, with the aim of accounting for the uncertainty of elemental association in geochemical mapping. To illustrate and validate the procedure, a case study was conducted wherein geochemical stream-sediment samples from the northwestern region of the province of Sichuan, China, were processed to map anomalies associated with disseminated gold mineralization. The results indicate that (1) the representativeness of elemental association for the underlying geological process is an important source of uncertainty for geochemical mapping; (2) the procedure presented here is effective in addressing the uncertainty of elemental associations in geochemical mapping; and (3) the study area can be classified into two clusters, each characterized by unique elemental associations that align well with the distribution of Paleozoic and Triassic lithological units, respectively. Furthermore, the region still holds great potential for the discovery of gold deposits, particularly in areas proximal to known mineralization sites.
Penentuan Harga Pokok Produksi dengan Metode Full Costing di Toko XYZ
Authors: Hafrida Elisa 
Published: June 2024

Penentuan harga pokok produksi yang tidak tepat, maka harga jualnya juga tidak akan tepat, bisa terlalu tinggi atau terlalu rendah, hal ini tentunya dapat mengakibatkan kerugian bagi perusahaan karena tidak dapat menutup biaya yang digunakan selama proses produksi (Hayat, 2019). Tujuan penelitian ini untuk mengetahui penentuan harga pokok produksi dengan menggunakan metode Full Costing di Toko XYZ. Sampel pada penelitian ini adalah semua biaya yang dikeluarkan selama produksi pada bulan Maret 2023. Data yang dikumpulkan berupa data biaya bahan baku, biaya tenaga kerja langsung, dan biaya overhead. Berdasarkan hasil perhitungan dengan metode Full Costing diperoleh harga pokok produksi, sebagai berikut : donat (Rp.4472), bolu klepon (Rp.20.472), roti tawar (Rp.10.408), bolu karamel (Rp.23.125), bolu pisang (Rp.14.269), brownies (Rp.14.463), bolu marmer (Rp.14.354), donat paha ayam (Rp.10.465), donat abon (Rp.15.155), roti sosis (Rp.10.739), roti pisang (Rp.10.612), roti keju (Rp.10.545) dan roti mesis coklat (Rp.10.532). Disarankan agar menerapkan metode Full Costing dalam menentukan harga pokok produksi untuk memperoleh laba yang akurat.
The commandments of Korney Chukovsky in the children’s poetry of Evgenios Trivizas: comparative analysis and translation strategies
Authors: Никольская А.П. , Кримпас П.Г. 
Published: June 2024

В статье вырабатываются стратегии перевода новогреческой детской поэзии на русский язык на основе сравнительного анализа текстов Е. Тривизаса и К. И. Чуковского по трем аспектам: смысловому, стилистическому и прагматическому. Рассматриваются жанровые соответствия, ритм и стиль, связь с народной стиховой культурой и художественные приемы. Исследуются задачи и трудности перевода, включая передачу образов и словотворчество.
The article develops strategies for translating modern Greek children’s poetry into Russian based on a comparative analysis of texts by E. Trivizas and K. I. Chukovsky in three aspects: semantic, stylistic and pragmatic. Genre correspondences, rhythm and style, connections with folk poetic culture and poetic technique are considered. The tasks and difficulties of translation are explored, including the of images and word creation.
Η Παναγία της Τήνου και οι προσκυνηματικές τελετουργίες στη σύγχρονη Ελλάδα
Authors: Varvounis Μ.G. 
Published: June 2024

In this study, the pilgrimage of the Virgin Mary in Tinos is examined, both with references to the oldest relevant literature, and based on a recently published by Al. Florakis two-volume related work, which constitutes a very important contribution, which will be a point of reference for later scholars, as it enriches the Greek folklore literature related to the branch of Religious Folklore, but also our folklore literature more broadly. The announcement focuses not only on the history, but also on the modern course of a well-known pilgrimage in the religious consciousness and ritual practice of the people, a sacred place of pilgrimage that combines the sacred awe of the epiphany with the thrill of the miraculous and the modern trends of crossing into forms more secularized. As the secularization, de-sacralization and disenchantment of the world gain more and more ground in our digital age, the knowledge of the history and ritual status of great and popular Christian pilgrimages becomes a safe guide for tracing the complex Greek popular religiosity. The case of the pilgrimage of ‘Megalochari’ of Tinos demonstrates this in the most complete way.
Στη μελέτη αυτή εξετάζεται το προσκύνημα της Παναγίας στην Τήνο, τόσο με αναφορές στην παλαιότερη σχετική βιβλιογραφία, όσο και με βάση ένα προσφάτως εκδοθέν από τον Αλ. Φλωράκη δίτομο σχετικό έργο, το οποίο συνιστά συμβολή σημαντικότατη, η οποία θα αποτελέσει σημείο αναφοράς για τους μεταγενέστερους μελετητές, καθώς πλουτίζει την ελληνική λαογραφική βιβλιογραφία σχετικά με τον κλάδο της Θρησκευτικής Λαογραφίας, αλλά και τη λαογραφική βιβλιογραφία μας ευρύτερα. Η ανακοίνωση εστιάζει όχι μόνο στην ιστορία, αλλά και στη σύγχρονη πορεία ενός καταξιωμένου στη θρησκευτική συνείδηση και την τελετουργική πρακτική των ανθρώπων προσκυνήματος, ενός ιερού προσκυνηματικού τόπου που συνδυάζει το ιερό δέος της ιεροφάνειας με την συγκίνηση της θαυματουργίας και τις σύγχρονες τάσεις της διάβασης σε μορφές περισσότερο εκκοσμικευμένες. Καθώς η εκκοσμίκευση, η αποϊεροποίηση και η απομάγευση του κόσμου κερδίζουν ολοένα και περισσότερο έδαφος στην ψηφιακή εποχή μας, η γνώση της ιστορίας και της τελετουργικής υπόστασης μεγάλων και λαοφιλών χριστιανικών προσκυνημάτων αποβαίνει οδηγός ασφαλής για την ανίχνευση της περίπλοκης ελληνικής λαϊκής θρησκευτικότητας. Η περίπτωση του προσκυνήματος της Μεγαλόχαρης της Τήνου, το καταδεικνύει με τον πληρέστερο τρόπο.
Life cycle rituals of Greeks of Russia: birth, wedding, funerals (based on the materials of ethnolinguistic expeditions held in 2022–2024)
Authors: Климова К.А. , Никитина И.О. , Пелевинова М.В. 
Published: June 2024

Статья посвящена описанию особенностей семейной обрядности греков, проживающих на территории современной России. Рассматривается родильная, свадебная и похоронная обрядность на основе материалов, собранных в этнолингвистических экспедициях на Северный Кавказ и Черноморское побережье России в 2022–2024 гг. В статье представлено описание ритуалов и ритуальной лексики на понтийском диалекте и тюркском диалекте, описаны особенности обрядовых действий в разных регионах.
This study investigates the characteristics of life cycle rituals among the Greek population residing in the territory of Russia. It delves into the practices associated with birth, marriage, and death rites, drawing on data gathered during ethnolinguistic expeditions conducted in the North Caucasus and along the Black Sea coast of Russia from 2022 to 2024. The research presents a detailed analysis of rituals and ritualistic lexicon in both the Pontic and Turkic dialects, and elucidates the distinct attributes of ritual performances across various geographic regions.
Pengembangan Aplikasi Klasifikasi Tingkat Kematangan Buah Apel Berdasarkan Warna Kulit Buah Apel dengan Metode Convolutional Neural Network
Authors: Rusli Hizkia Natanael 
Published: June 2024

This study aims to develop an image classification application for the ripeness level of apples using the Convolutional Neural Network method to group image data so that it can assist in determining the ripeness of apples. The dataset used is an image of unripe, ripe, and rotten apples. The data will be trained to obtain accuracy to determine the level of ripeness of apples. In this study, the accuracy was 96% for 20 epochs and 98% for 40 epochs.
Buenaventura: la correspondencia entre verdad y belleza en Breviloquium, I, 6
Authors: Cresta Gerald 
Published: June 2024

A partir de las reflexiones propuestas por Buenaventura en Breviloquium, I, 6, los conceptos trascendentales unidad, verdad y bondad pueden ser pensados como resultado de las diversas relaciones de indivisión interna del ser. Estas “condiciones nobilísimas y generalísimas del ser”, como las llama Buenaventura, son presentadas en el texto a modo de apropiaciones divinas y por esa razón triádica no incluyen en principio a la belleza. Sin embargo, enseguida es mencionada bajo la forma de una correspondencia esencial verdad-belleza. De esta manera, la belleza comporta una cualidad formal intrínseca de la verdad, que le permite transmitir a la percepción tanto sensorial cuanto intelectual la trama íntima de la estructura del mundo. El presente trabajo señala las instancias deductivas y simbólicas de esa belleza participada.
Cruzando por oscuras quebradas
Authors: Tonello Amadeo 
Published: June 2024

La Exhortación Apostólica Amoris laetitia presenta un rico cuerpo de doctrina sobre el matrimonio y la familia, en el que se destaca una propuesta de discernimiento pastoral para el tratamiento de las situaciones matrimoniales difíciles. Ello ha generado diversas preguntas, entre ellas, particularmente, la siguiente: ¿pueden los divorciados en nueva unión que viven conyugalmente acercarse al sacramento de la Comunión? En el presente trabajo se analizan los criterios ofrecidos por el Papa para intentar dar una respuesta a esa pregunta y se proponen caminos pastorales para el discernimiento de las situaciones matrimoniales difíciles.
Hacia una teología del cambio de época a partir de la reducción teologal del “peregrinando-nos”
Authors: Ramos Gerardo Daniel 
Published: June 2024

Presento mi Teología del cambio de época [=TCE] como una teología del “peregrinando-nos”, reducción teologal que se corresponde con el “estar siendo discípulo/s misionero/s”. Al “peregrinando-nos” le son inherentes el icono sapiencial del “camino” y el icono teologal del “santuario”: el primero remite al mundo y el segundo remite a Dios. En la dialéctica controlada existente entre ambos iconos vamos desplegando un proceso de “autotrascendencia teocéntrica en la consistencia”. Este yo peregrinante tiene una vertiente personal (el creyente individual) y otra colectiva (el pueblo de Dios peregrino, pero también implícitamente, una nación en camino). La peregrinación se va desplegando espacio-temporalmente, desde la existencialidad histórica en progresiva apertura al misterio trascendente. O también, desde la progresiva vivencia teologal de las virtudes en diálogo interpelante con todo lo que de bueno, bello y verdadero vamos encontrando por el camino. Esto nos conduce a una cada vez más satisfactoria vida en el Espíritu, renacida de lo alto desde el “santuario” descubierto como ya inhabitando en el mismo “camino”, lo cual traduce y expresa muy bien e inculturadamente lo propio de la esperanza teologal cristiana. A esta teología, el magisterio pastoral del Papa Francisco le fue confiriendo un dinamismo evangelizador que no tenía, al menos no en el mismo grado, en su fundante Trilogía.