bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcomes of proximal row carpectomy versus four-corner arthrodesis for post-traumatic wrist arthropathy: a systematic review
Authors: Saltzman B. M. , Frank J. M. , Slikker W. , Fernandez J. J. , Cohen M. S. , Wysocki R. W. 
Published: October 2014

We conducted a systematic review of studies reporting clinical outcomes after proximal row carpectomy or to four-corner arthrodesis for scaphoid non-union advanced collapse or scapholunate advanced collapse arthritis. Seven studies (Levels I–III; 240 patients, 242 wrists) were evaluated. Significantly different post-operative values were as follows for four-corner arthrodesis versus proximal row carpectomy groups: wrist extension, 39 (SD 11º) versus 43 (SD 11º); wrist flexion, 32 (SD 10º) versus 36 (SD 11º); flexion-extension arc, 62 (SD 14º) versus 75 (SD 10º); radial deviation, 14 (SD 5º) versus 10 (SD 5º); hand grip strength as a percentage of contralateral side, 74% (SD 13) versus 67% (SD 16); overall complication rate, 29% versus 14%. The most common post-operative complications were non-union (grouped incidence, 7%) after four-corner arthrodesis and synovitis and clinically significant oedema (3.1%) after proximal row carpectomy. Radial deviation and post-operative hand grip strength (as a percentage of the contralateral side) were significantly better after four-corner arthrodesis. Four-corner arthrodesis gave significantly greater post-operative radial deviation and grip strength as a percentage of the opposite side. Wrist flexion, extension, and the flexion-extension arc were better after proximal row carpectomy, which also had a lower overall complication rate. Level of evidence: Level III (Level I-III studies), Systematic Review. Therapeutic.
How I treat patients with massive hemorrhage
Authors: Johansson Pär I. , Stensballe Jakob , Oliveri Roberto , Wade Charles E. , Ostrowski Sisse R. , Holcomb John B. 
Published: October 2014

AbstractMassive hemorrhage is associated with coagulopathy and high mortality. The transfusion guidelines up to 2006 recommended that resuscitation of massive hemorrhage should occur in successive steps using crystalloids, colloids, and red blood cells (RBCs) in the early phase and plasma and platelets in the late phase. With the introduction of the cell-based model of hemostasis in the mid-1990s, our understanding of the hemostatic process and of coagulopathy has improved. This has contributed to a change in resuscitation strategy and transfusion therapy of massive hemorrhage along with an acceptance of the adequacy of whole blood hemostatic tests to monitor these patients. Thus, in 2005, a strategy aiming at avoiding coagulopathy by proactive resuscitation with blood products in a balanced ratio of RBC:plasma:platelets was introduced, and this has been reported to be associated with reduced mortality in observational studies. Concurrently, whole blood viscoelastic hemostatic assays have gained acceptance by allowing a rapid and timely identification of coagulopathy along with enabling an individualized, goal-directed transfusion therapy. These strategies joined together seem beneficial for patient outcome, although final evidence on outcome from randomized controlled trials are lacking. We present how we in Copenhagen and Houston, today, manage patients with massive hemorrhage.
CD4+ invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T cells
Authors: Schneidawind Dominik , Pierini Antonio , Alvarez Maite , Pan Yuqiong , Baker Jeanette , Buechele Corina , Luong Richard H. , Meyer Everett H. , Negrin Robert S. 
Published: October 2014

Key Points
Low doses of adoptively transferred donor CD4+ iNKT cells protect from GVHD while preserving graft-versus-tumor effects. Donor CD4+ iNKT cells inhibit proliferation of alloreactive T cells and promote robust expansion of donor Tregs.
Brentuximab vedotin
Authors: Ansell Stephen M. 
Published: October 2014

Abstract
Brentuximab vedotin is an anti-CD30 antibody-drug conjugate with proven efficacy in patients with CD30+ malignancies, including classical Hodgkin lymphoma and anaplastic large cell lymphoma. Promising activity has also been seen in other lymphomas that express CD30. Because of its acceptable toxicity profile and significant clinical efficacy, single-agent brentuximab vedotin is an approved treatment for relapsed patients with these diseases. Brentuximab vedotin has safely been combined with chemotherapy and is now being compared with standard treatments in randomized trials.
Safety and efficacy of rituximab in adult immune thrombocytopenia: results from a prospective registry including 248 patients
Authors: Khellaf Mehdi , Charles-Nelson Anaïs , Fain Olivier , Terriou Louis , Viallard Jean-François , Cheze Stéphane , Graveleau Julie , Slama Borhane , Audia Sylvain , Ebbo Mikael , Le Guenno Guillaume , Cliquennois Manuel , Salles Gilles , Bonmati Caroline , Teillet France , Galicier Lionel , Hot Arnaud , Lambotte Olivier , Lefrère François , Sacko Salimatou , Kengue Dieudonné Kilendo , Bierling Philippe , Roudot-Thoraval Françoise , Michel Marc , Godeau Bertrand 
Published: October 2014

Key Points
Tolerance of rituximab is acceptable in ITP, and with its benefit/risk ratio may remain a valid option for treating ITP in adults.
Prevalence of active foot disease and foot disease risk factors in a subacute inpatient rehabilitation facility: a cross‐sectional prevalence study
Authors: Earl Brenton J , Lazzarini Peter A , Kinnear Ewan M , Cornwell Petrea L 
Published: October 2014

AbstractBackgroundAustralian subacute inpatient rehabilitation facilities face significant challenges from the ageing population and the increasing burden of chronic disease. Foot disease complications are a negative consequence of many chronic diseases. With the rapid expansion of subacute rehabilitation inpatient services, it seems imperative to investigate the prevalence of foot disease and foot disease risk factors in this population. The primary aim of this cross‐sectional study was to determine the prevalence of active foot disease and foot disease risk factors in a subacute inpatient rehabilitation facility.MethodsEligible participants were all adults admitted at least overnight into a large Australian subacute inpatient rehabilitation facility over two different four week periods. Consenting participants underwent a short non‐invasive foot examination by a podiatrist utilising the validated Queensland Health High Risk Foot Form to collect data on age, sex, medical co‐morbidity history, foot disease risk factor history and clinically diagnosed foot disease complications and foot disease risk factors. Descriptive statistics were used to determine the prevalence of clinically diagnosed foot disease complications, foot disease risk factors and groups of foot disease risk factors. Logistic regression analyses were used to investigate any associations between defined explanatory variables and appropriate foot disease outcome variables.ResultsOverall, 85 (88%) of 97 people admitted to the facility during the study periods consented; mean age 80 (±9) years and 71% were female. The prevalence (95% confidence interval) of participants with active foot disease was 11.8% (6.3 – 20.5), 32.9% (23.9 – 43.5) had multiple foot disease risk factors, and overall, 56.5% (45.9 – 66.5) had at least one foot disease risk factor. A self‐reported history of peripheral neuropathy diagnosis was independently associated with having multiple foot disease risk factors (OR 13.504, p = 0.001).ConclusionThis study highlights the potential significance of the burden of foot disease in subacute inpatient rehabilitation facilities. One in eight subacute inpatients were admitted with active foot disease and one in two with at least one foot disease risk factor in this study. It is recommended that further multi‐site studies and management guidelines are required to address the foot disease burden in subacute inpatient rehabilitation facilities.
Decentralized group formation
Authors: Chmielowiec Anna , Voulgaris Spyros , Steen Maarten van 
Published: October 2014

Abstract
Imagine a network of entities, being it replica servers aiming to minimize the probability of data loss, players of online team-based games and tournaments, or companies that look into co-branding opportunities. The objective of each entity in any of these scenarios is to find a few suitable partners to help them achieve a shared goal: replication of the data for fault tolerance, winning the game, successful marketing campaign. All information attainable by the entities is limited to the profiles of other entities that can be used to assess the pairwise fitness. How can they create teams without help of any centralized component and without going into each other’s way? We propose a decentralized algorithm that helps nodes in the network to form groups of a specific size. The protocol works by finding an approximation of a weighted k-clique matching of the underlying graph of assessments. We discuss the basic version of the protocol, and explain how dissemination via gossiping helps in improving its scalability. We evaluate its performance through extensive simulations.
Analysis of microsatellites in the vulnerable orchid Gastrodia flavilabella: the development of microsatellite markers, and cross-species amplification in Gastrodia
Authors: Tsai Chi-Chu , Wu Pei-Yin , Kuo Chia-Chi , Huang Min-Chun , Yu Sheng-Kun , Hsu Tsai-Wen , Chiang Tzen-Yuh , Chiang Yu-Chung 
Published: October 2014

Abstract

Background

Gastrodia flabilabella is a mycoheterotrophic orchid that obtains carbohydrates and nutrients from its symbiotic mycorrhizal fungi. The species is an endemic and vulnerable species enlisted in the “A Preliminary Red List of Taiwanese Vascular Plants” according to the IUCN Red List Categories and Criteria Version 3.1. G. flabilabella dwells the underground of broadleaf and coniferous forest with richness litter. Based on herbarium records, this species is distributed in central Taiwan. Twenty eight microsatellite loci were developed in G. flabilabella and were tested for cross-species amplification in additional taxa of G. confusoides, G. elata, and G. javanica. We estimated the genetic variation that is valuable for conservation management and the development of the molecular identification system for G. elata, a traditional Chinese medicine herb.

Results
Microsatellite primer sets were developed from G. flabilabella using the modified AFLP and magnetic bead enrichment method. In total, 257 microsatellite loci were obtained from a magnetic bead enrichment SSR library. Of the 28 microsatellite loci, 16 were polymorphic, in which the number of alleles ranged from 2 to 15, with the observed heterozygosity ranging from 0.02 to 1.00. In total, 15, 13, and 7 of the loci were found to be interspecifically amplifiable to G. confusoides, G. elata, and G. javanica, respectively.

Conclusions
Amplifiable and transferable microsatellite loci are potentially useful for future studies in investigating intraspecific genetic variation, reconstructing phylogeographic patterns among closely related species, and establishing the standard operating system of molecular identification in Gastrodia.
Use of a National Continuing Medical Education Meeting to Provide Simulation-Based Training in Temporary Hemodialysis Catheter Insertion Skills: A Pre-Test Post-Test Study
Authors: Clark Edward G , Paparello James J , Wayne Diane B , Edwards Cedric , Hoar Stephanie , McQuillan Rory , Schachter Michael E , Barsuk Jeffrey H 
Published: October 2014

Background: Simulation-based-mastery-learning (SBML) is an effective method to train nephrology fellows to competently insert temporary, non-tunneled hemodialysis catheters (NTHCs). Previous studies of SBML for NTHC-insertion have been conducted at a local level. Objectives: Determine if SBML for NTHC-insertion can be effective when provided at a national continuing medical education (CME) meeting. Describe the correlation of demographic factors, prior experience with NTHC-insertion and procedural self-confidence with simulated performance of the procedure. Design: Pre-test – post-test study. Setting: 2014 Canadian Society of Nephrology annual meeting. Participants: Nephrology fellows, internal medicine residents and medical students. Measurements: Participants were surveyed regarding demographics, prior NTHC-insertion experience, procedural self-confidence and attitudes regarding the training they received. NTHC-insertion skills were assessed using a 28-item checklist. Methods: Participants underwent a pre-test of their NTHC-insertion skills at the internal jugular site using a realistic patient simulator and ultrasound machine. Participants then had a training session that included a didactic presentation and 2 hours of deliberate practice using the simulator. On the following day, trainees completed a post-test of their NTHC-insertion skills. All participants were required to meet or exceed a minimum passing score (MPS) previously set at 79%. Trainees who did not reach the MPS were required to perform more deliberate practice until the MPS was achieved. Results: Twenty-two individuals participated in SBML training. None met or exceeded the MPS at baseline with a median checklist score of 20 (IQR, 7.25 to 21). Seventeen of 22 participants (77%) completed post-testing and improved their scores to a median of 27 (IQR, 26 to 28; p < 0.001). All met or exceeded the MPS on their first attempt. There were no significant correlations between demographics, prior experience or procedural self-confidence with pre-test performance. Limitations: Small sample-size and self-selection of participants. Costs could limit the long-term feasibility of providing this type of training at a CME conference. Conclusions: Despite most participants reporting having previously inserted NTHCs in clinical practice, none met the MPS at baseline; this suggests their prior training may have been inadequate.
Single-Tube, Highly Parallel Mutation Enrichment in Cancer Gene Panels by Use of Temperature-Tolerant COLD-PCR
Authors: Castellanos-Rizaldos Elena , Richardson Katherine , Lin Rui , Wu Grant , Makrigiorgos Mike G 
Published: October 2014

Abstract

BACKGROUND
Multiplexed detection of low-level mutations presents a technical challenge for many technologies, including cancer gene panels used for targeted-resequencing. Analysis of mutations below approximately 2%–5% abundance in tumors with heterogeneity, samples with stromal contamination, or biofluids is problematic owing to increased noise from sequencing errors. Technologies that reduce noise via deep sequencing unavoidably reduce throughput and increase cost. Here we provide proof of principle that coamplification at lower denaturation temperature (COLD)-PCR technology enables multiplex low-level mutation detection in cancer gene panels while retaining throughput.

METHODS
We have developed a multiplex temperature-tolerant COLD-PCR (fast-TT-COLD-PCR) approach that uses cancer gene panels developed for massively parallel sequencing. After multiplex preamplification from genomic DNA, we attach tails to all amplicons and perform fast-TT-COLD-PCR. This approach gradually increases denaturation temperatures in a step-wise fashion, such that all possible denaturation temperatures are encompassed. By introducing modified nucleotides, fast-COLD-PCR is adapted to enrich for melting temperature (Tm)-increasing mutations over all amplicons, in a single tube. Therefore, in separate reactions, both Tm-decreasing and Tm-increasing mutations are enriched.

RESULTS
Using custom-made and commercial gene panels containing 8, 50, 190, or 16 000 amplicons, we demonstrate that fast-TT-COLD-PCR enriches mutations on all examined targets simultaneously. Incorporation of deoxyinosine triphosphate (dITP)/2,6-diaminopurine triphosphate (dDTP) in place of deoxyguanosine triphosphate (dGTP)/deoxyadenosine triphosphate (dATP) enables enrichment of Tm-increasing mutations. Serial dilution experiments demonstrate a limit of detection of approximately 0.01%–0.1% mutation abundance by use of Ion-Torrent and 0.1%–0.3% by use of Sanger sequencing.

CONCLUSIONS
Fast-TT-COLD-PCR improves the limit of detection of cancer gene panels by enabling mutation enrichment in multiplex, single-tube reactions. This novel adaptation of COLD-PCR converts subclonal mutations to clonal, thereby facilitating detection and subsequent mutation sequencing.
Patron Driven Acquisition – eine Herausforderung (auch) für Verbundzentralen
Authors: Albrecht Rita 
Published: October 2014

Zusammenfassung:
Das noch relativ junge Modell „Patron Driven Acquisition“ wird inzwischen von vielen Bibliotheken für die Erwerbung von E-Books praktiziert. Dabei wird nach einem bibliothekseigenen Profil eine Sammlung von E-Books (manchmal auch Printtitel) durch einen Anbieter zur Nutzung bereitgestellt, ein Kauf aber erst durch die Anforderung des Dokuments durch einen Bibliotheksbenutzer ausgelöst, wofür es verschiedene Modelle und Modalitäten je nach Anbieter gibt. Verbundbibliotheken erwarten von ihren Verbundzentralen auch für diese Erwerbungsform ein schnelles, umfassendes Metadatenhandling und stellen sie damit vor neue Herausforderungen. Der folgende Beitrag beschreibt exemplarisch die Metadatenpraxis im HeBIS-Verbund.
On sarcasm, social awareness, and gender
Authors: Drucker Ari , Fein Ofer , Bergerbest Dafna , Giora Rachel 
Published: October 2014

AbstractSarcastic irony, uttered in four (within and between) gender-based settings, is used here as a tool to diagnose affective attitudes toward women. The kind of sarcasm tested here is an aggressive type of humor, whereby a speaker derides another individual, turning her or him into the victim of the humorous utterance. Finding this kind of irony less or more pleasing allows indexing between- and within-group attitudes. Participants were overall nonsexist, scoring low on sexism scales, but male participants were still more sexist than female participants. Results show that, as predicted by Ariel and Giora (1998), female participants fully adopted a feminine point of view, enjoying sarcastic irony best when it was directed by women at men and least when it was directed by women at women. Being more sexist, our male participants adopted a feminine point of view only partially, enjoying sarcastic irony more when directed at men than directed at women, regardless of the speaker's gender.
A relevance-theoretic perspective on humorous irony and its failure
Authors: Piskorska Agnieszka 
Published: October 2014

AbstractThis paper adopts the relevance-theoretic account of irony to describe the features of humorous irony and to elucidate the nuances of its failure. In connection to the humorous potential of irony, a number of properties it shares with some types of humor are discussed, such as exploiting incongruity, being targeted at a victim, being creative, carrying an element of surprise, involving metarepresentational abilities, and establishing a bond between the speaker and hearer. It is further observed that ironic utterances produced for the purpose of generating humor and increasing rapport between interlocutors may fail to achieve this aim to various degrees and due to a number of causes. Analyses of several examples indicate that the various causes of ironic misfires can be traced to failures of the inferential processes postulated by Relevance Theory as responsible for communicating irony: identifying a dissociative propositional attitude, representing the content of the proposition echoed, and attributing it to a source. Besides, it is claimed that humorous irony is used not only to communicate an attitude but also to have it accepted by the hearer, which is why the latter's rejection of the speaker-envisaged ironic attitude counts as another type of irony failure.
Non-immune hydrops fetalis as a diagnostic and survival problems: what do we tell the parents?
Authors: Turgal Mert , Ozyuncu Ozgur , Boyraz Gokhan , Yazicioglu Aslihan , Sinan Beksac Mehmet 
Published: October 2014

Abstract

Objective: Nonimmune hydrops fetalis (NIHF) is one of the most difficult problems related to pregnancy. The aim of this study was to evaluate the etiological analysis as well as the fetal and neonatal outcomes of NIHF.

Methods: We reviewed the prenatal sonographic data and postnatal medical records of pregnant women diagnosed as NIHF in our hospital between January 2001 and May 2013. All cases were categorized using 12 etiological classification groups. Demographic data, diagnostic laboratory parameters, karyotyping results, sonographic and autopsy findings, postnatal final diagnoses, and perinatal mortality rates were also recorded.

Results: This study included 147 cases. The mean gestational age at the time of the initial diagnosis was 23.84±6.30 weeks. Cardiovascular causes were the most common (21.7%), followed by structural abnormalities (17.0%), chromosomal abnormalities (6.8%), and skeletal dysplasias (5.4%). Chromosomal abnormalities were detected in 12.8% of these cases. The most common karyotype abnormality was monosomy X. Postmortem autopsy was performed in 50 (34%) cases, and at least one finding was detected in 40 (80%) of these cases. The overall mortality rate was 78.2%. The gestational week at delivery, birth weight, and Apgar score (1st and 5th min) showed a statistically significant difference between exitus and surviving fetuses (P<0.05).

Conclusion: NIHF can lead to high perinatal morbidity and mortality, yet its etiopathology remains poorly understood. Early diagnosis of NIHF gives parents an opportunity to make an informed choice about the possible complications of a pregnancy.
El surgimiento de la ganadería en la Ciénega de Chapala (Michoacán, México). El caso de la Hacienda Guaracha (siglos XVI-XIX)
Authors: Dávila Moreno María Elena Nancy 
Published: October 2014

En México, durante la Colonia, la ganadería surgió como un instrumento para privatizar las antiguas tierras indígenas y en torno a ésta se fueron generando complejos mecanismos de articulación social, institucionales y de defensa de privilegios de grupos territoriales, lo cual no contempló las devastadoras consecuencias ecológicas que implicaba su desarrollo. El objeto de estudio es la región de la Ciénega de Chapala, Michoacán (México), con el fin de vincular los cambios institucionales con la alteración del espacio físico, así como sus efectos identificando cuáles han sido los eventos a lo largo de la historia que determinaron su actual geografía. La Ciénega de Chapala, ha experimentado un importante grado de alteración en su paisaje, derivado de la apertura a la agricultura y a la ganadería extensiva desde el siglo XVI y, el caso de la Hacienda Guaracha es un ejemplo de cómo ocurrieron estos cambios desde las primeras concentraciones de tierra y agua en el siglo XVI hasta el final del siglo XIX. Palabras clave: ganadería, cambio institucional, estancia ganadera, Ciénega de Chapala, hacienda La Guaracha. The Emergence of Livestock in the Cienega de Chapala (Michoacán, Mexico). The Case of the Hacienda Guaracha (XVI-XIX centuries) AbstractIn Mexico, during the colonial period, livestock emerged as a tool to privatize former Indian lands and around them complex social mechanisms were generated which were institutional articulated to defend the privileges of territorial groups, which did not consider the devastating consequences involving ecological development. The study object is the region of the Cienega de Chapala, Michoacan (México), in order to link institutional changes with the alteration of the physical space as well as their effects by identifying what were the events throughout history that led to its current geography. The Cienega de Chapala has experienced a significant degree of changes in its landscape, derived from the opening to agriculture and extensive livestock since the sixteenth century. The case of Hacienda Guaracha is an example of how these changes occurred from the first land and water concentrations in the sixteenth century to the late nineteenth century. Key words: livestock, institutional change, cattle ranch, Cienega de Chapala, Hacienda (Ranch) La Guaracha.