bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposal for a clinicopathological prognostic score for resected gastric cancer patients
Authors: Díaz del Arco Cristina , Estrada Muñoz Lourdes , Molina Roldán Elena , Ortega Medina Luis , García Gómez de las Heras Soledad , Chávez Ángela , Fernández Aceñero Ma Jesús 
Published: August 2024

Background:
Factors other than pTNM stage have been associated with gastric cancer (GC) prognosis, and several alternative prognostic scores have been constructed. Our aims are to identify prognostic factors in western GC patients and to build clinicopathological prognostic models for overall survival (OS) and disease-free survival (DFS).

Methods:
A Retrospective study of 204 cases of GC resected during the years 2000 to 2014 was conducted in our hospital. Clinicopathological features were assessed, univariate and multivariate analysis were performed and prognostic scores were constructed.

Results:
Most patients were diagnosed at pTNM stages II and III (36.9% and 48.1%, respectively). According to Laurén classification, tumors were intestinal (55.8%), diffuse (35.2%) and mixed (9%). During follow-up, 43.5% of patients had tumor recurrence, and 28.6% died due to tumor. Univariate analysis showed that patient age, Laurén subtype, signet-ring cell morphology, pTNM stage, tumor grade, perineural invasion, growth pattern, intratumoral inflammation, adjuvant therapy, and desmoplasia were significantly related to tumor progression or death. Multivariate analysis showed that Laurén subtype, pT stage, and lymph node ratio (LNR) were significantly and independently associated with GC recurrence. Laurén subtype and LNR were significantly related to patient survival. Prognostic scores for tumor progression and death were developed and patients were classified into four prognostic groups which showed good prognostic performance.

Conclusion:
A prognostic model comprising histological features such as Laurén subtype can be easily applied in clinical practice, and provides more prognostic information than pTNM stage alone. These models can further stratify resected GC patients and have the potential to aid in the individualization of patient management.
The impact of social media accounts on periocular cosmetic surgeries
Authors: Alshaalan Hayfaa S. , AlTamimi Lama A. , Alshayie Reema A. , Alsuhaibani Adel H. 
Published: August 2024

PURPOSE:
The study aims to assess the impact of social media on patients who underwent periocular cosmetic surgeries during 2019 and to determine the appropriate platforms to enrich the knowledge and awareness of the general Saudi population regarding periocular cosmetic surgeries.

METHODS:
A cross-sectional study was conducted at Ibn Rushd Hospital, Riyadh, Saudi Arabia. Three hundred and ninety-five participants with periocular cosmetic surgeries in 2019 were recruited for the study. The questionnaire included 43 questions distributed under four domains: demographics, personal and family history of periocular eye surgeries, influence of social media on cosmetic eye procedures, and psychological effects of social media.

RESULTS:
Periocular cosmetic surgeries were more common among women, with eyelid surgery being the most popular type. About 48.9% of the participants knew their oculoplastic surgeons from social media platforms, and over 57% who used accounts on social media were interested in cosmetology managed by nonphysicians. The majority of the participants (64.1%) chose Instagram as a social media platform to find an oculoplastic surgeon. Consequently, 91.6% stated that seeing before and after photos on social media platforms affected their decision in selecting their oculoplastic surgeon. Besides, 82.8% revealed that visiting surgeons’ clinic came as a step next to their search for their accounts on social media.

CONCLUSION:
The majority of the participants were, somewhat or another, affected by social media and this is due to people's belief regarding social media as a beneficial source of medical information that can provide reviews and expert opinion. The accuracy of the information presented in social media accounts managed by both physicians and nonphysicians is essential in making the appropriate decision for undergoing this kind of surgeries or not.
Evaluation of the efficacy of botulinum toxin injection for the treatment of infantile esotropia
Authors: Alam Muneeb , Alshammari Sarah , Alobaisi Saif , Alfreihi Shatha 
Published: August 2024

PURPOSE:
The purpose of this study was to investigate the outcomes and complications of botulinum toxin injection (BTX) as the primary treatment of infantile esotropia (IET).

METHODS:
We included patients with IET who underwent BTX from 2015 to 2020. IET was defined as esotropia present before 12 months of age, with no significant refractive error, or limitation of rotations. We defined success as a postoperative angle of 0–10 prism diopters (PD).

RESULTS:
Sixty-three patients met our inclusion criteria (38 male patients [60.3%]). The mean age was 18 ± 8 months (range: 10–26), onset 6 ± 4 months (range: 2–10), and follow-up of 29 ± 25 months (range: 4–54). Amblyopia was present in 45 patients (71.4%). Number of BTX was, 1 in 42 (66.7%), 2 in 17 (27%), 3 in 4 (4.8%), and 4 in 1 (1.6%). The 1st BTX mean dose was 7 ± 3 international unit (range: 4–10) and a mean duration of 4 ± 1 min (range: 3–5). The mean preoperative angle of deviation was 42.30 ± 13.73 PD. The mean postoperative angle of deviation was 16.07 ± 16.15 PD (P = 0.0001). At the final follow-up, BTX was successful in 32 (51%) (success after 1st BTX 33.3%, 2nd BTX 46.03%, and 3rd BTX 50.79%). Twelve patients (19%) had undergone surgery due to the failure of BTX. Postoperative observations included transient ptosis 29 (49.2%), transient exotropia 36 (57.14%), inferior oblique overaction 13 (20.6%), vertical deviation 8 (12.7%), and persistent ptosis 1 (1.6%).

CONCLUSION:
The success rate of BTX for IET was 51%. BTX can be offered as an alternative to surgery to those who cannot undergo prolonged anesthesia or where accurate measurements could not be obtained.
Preoperative universal screening of coronavirus disease 2019 during Omicron outbreak in patients undergoing ophthalmic surgeries: Experience from a tertiary eye care center in Saudi Arabia
Authors: Albuainain Abdulrahman , Alkharashi Majed 
Published: August 2024

PURPOSE:
This study aims to determine the frequency of coronavirus disease 2019 (COVID-19) during Omicron outbreak among patients scheduled for elective and emergency ophthalmic surgeries in a tertiary eye care center in Saudi Arabia.

METHODS:
This observational retrospective study was performed between December 1, 2021, and February 28, 2022, in a single tertiary eye care center in Riyadh, Saudi Arabia. All patients who were given appointments for elective or emergency surgeries were included. All patients underwent preoperative nasopharyngeal and oropharyngeal reverse transcription–polymerase chain reaction testing for the severe acute respiratory syndrome coronavirus 2. A retrospective chart review of all patients who tested positive for COVID-19 during Omicron outbreak was performed for the demographic and clinical information, presence of symptoms upon presentation, nature and urgency of the scheduled surgical intervention, and the overall outcomes.

RESULTS:
A total of 851 patients were scheduled for elective and emergency ophthalmic surgeries during the study period. The mean age of all patients was 58.2 years; 451 were males (52.9%) and 400 were females (47%). Of 851 patients tested for the COVID-19 during Omicron outbreak, the test was positive in 65 (7.6%) patients. All patients who tested positive for the COVID-19 during Omicron outbreak were asymptomatic at the time of swabbing. No patient-related perioperative complications or health-care workers’ affection secondary to exposure to positive cases was documented.

CONCLUSION:
The study showed that almost 1 in 13 patients scheduled for elective or emergency ophthalmic surgeries may test positive for the COVID-19 during Omicron outbreak. All positive cases were asymptomatic at the time of swabbing, highlighting the importance of routine preoperative screening for COVID-19.
Association between the body image perception, anthropometric measurements, and physical activity among the physiotherapy students
Authors: Bangera Nikhitha S. , Shetty Archana , Behera Debasis , Nalupurakkal Vipinnath Eranholy 
Published: August 2024

ABSTRACT

Background:
Body image perception (BIP) is associated with self-perception. Excessive concern about body image and body image dissatisfactions (BIDs) are linked to the risk factors for eating disorders, low self-esteem, depression, and less physical activity (PA), in turn leading to obesity. It is still unclear how a physiotherapy student perceives themselves.

Aims:
The objective of the study is to find the association between the BIP, anthropometric measurements, and PA.

Subjects and Methods:
The study was conducted at Alva’s College of Physiotherapy, Moodbidri. This is a correlation type of study. A total of 127 physiotherapy students who were between the age group of 18 and 25 years were recruited for the study based on the inclusion criteria. Body mass index (BMI) and skinfold (SF) measurement were measured using a syndex skin fold calliper. The International Physical Activity Questionnaire-Short Form and Body Shape Questionnaire were used to assess PA and BIP, respectively.

Results:
The study showed a significant association between BIP and BMI and SF measurements, where females are showing higher BID, whereas males are showing no significant result. PA and BID did not show any significant association among males and females.

Conclusions:
The findings of this study showed that there is a high incidence of BID among the physiotherapy students. Even though there was a good-to-excellent level of body fat among the university students, a high rate of BID was noted, especially among the female students.
Effects of offset load training in the taper phase of Indian mixed martial arts fighters: An experimental study
Authors: Krishnan Vijaya , Sayed Umran 
Published: August 2024

ABSTRACT

Background:
Mixed martial arts (MMA) is a combat sport gaining popularity in the Indian Sports Field. This sport is still underdeveloped, with variable methods of training and practices being established. There is a dearth of literature regarding the evidence available for the development of the fighter profile and body physiology. This study aims to address the use of offset loading during the taper phase of training to prepare athletes for competition.

Methodology:
An experimental study was conducted on 30 professional MMA fighters within 18–40 years. The fighters were divided into Group A, who followed traditional weight-cutting practices, while Group B followed offset loading protocol for 3 weeks. The outcomes were assessed for physical-, psychological-, and sport-specific features.

Results:
Both the groups showed statistically significant differences when compared within the groups using the Student’s t-test. In comparison between the two groups, Group B showed significant differences.

Conclusion:
Although both methods are fruitful, offset loading is an effective method to cut down and make championship weight than the traditional method with multiple positive effects on a fighter’s performance.
A 9-week (beginner) recreational runner training program for 5 km distance
Authors: Babkair Reem Abdullah 
Published: August 2024

ABSTRACT
The popularity of running is increasing worldwide with increased awareness of general well-being among people of all ages. Being easily accessible and with only a pair of shoes needed, many recreational runners practice this sport away from competitions. This review aims to illustrate a 9-week training program for the novice recreational runner to run for 5 km. The training program is designed according to runners’ physiological and biomechanical requirements. Strength and endurance training are combined on nonconsecutive six days per week. The strength training aims to strengthen upper limbs, lower limbs, and core muscles depending solely on body weight with no extra load since endurance runners do not require the power component or direction changes. The endurance training is structured to improve the maximal oxygen uptake and running economy to avoid rapid fatigue. The program also offers a warming-up routine to promote body preparation for physical activity to minimize the risk of injuries, in addition to cooling-down prescriptions to enhance musculoskeletal recovery and future performance. On the seventh day of the week, the runner can choose between active recovery exercise or complete rest. Active recovery is recommended to maintain the physiological attributes gained from the combined strength and endurance training.
Spontaneous multiple intracerebral hemorrhage
Authors: Siddiqui Nauman Amin , Aggarwal Amitesh , Narang Shiva 
Published: August 2024

Abstract:
Stroke is one of the leading causes of morbidity and mortality across the world. People are left with varying degrees of deficits if they survive. It can be ischemic and hemorrhagic in nature. Spontaneous multiple intracerebral hemorrhage is a rare form of hemorrhagic stroke. It, a life-threatening condition, can occur due to multiple etiologies. Here, we discuss an interesting case of a young male who presented with generalized seizure activity secondary to an unusual diagnosis. We further elaborate our understanding of the possible etiologies.
A pathologic fracture revealing sarcoid dactylitis
Authors: Cherif Yousra , Chebbi Donia , Derbel Samar , Hentati Olfa , Dahmen Fatma Ben , Abdallah Meya 
Published: August 2024

Abstract:
A 47-year-old woman presented sarcoid dactylitis revealed by a pathologic fracture of the left small finger. She had swollen and painful fingers. The hands X-ray showed cystic lesions and bone destruction. The RMI revealed bilateral asymmetric dactylitis with destructive lesions of the phalanges and periosteal granulomas. Otherwise, there were no other sarcoidosis manifestations. The patient received steroids and then methotrexate because of a relapse. The outcome was good.
Impact of coronavirus disease 2019 pandemic first wave on resident doctors in a tertiary care center Meerut
Authors: Sharma Shweta , Singh Dhanveer , Singh Dhirendra Pratap , Singh Deeksha , Mishra Rajat 
Published: August 2024

Abstract:

OBJECTIVE:
As the novel, the coronavirus pandemic had a great impact on our community professionals from all the specialties were greatly affected by the same. Similarly, our doctors’ community was under very much stress during this pandemic; therefore, this study was conducted to look for the effect of this pandemic on resident doctors in tertiary care center in Meerut.

METHODS:
This study was conducted on resident doctors in LLRM Medical College, Meerut, who came coronavirus disease 2019 (COVID-19) positive after either COVID duty or through working actively in different areas of the hospital.

RESULTS:
Our study demonstrated more infection in medicine residents (37%). The most cases were in the age group of 25–30 years. The majority of cases were males (66.7%). All the residents were symptomatic and none needed intensive care unit admission and all recovered with no mortality. Regarding maximum applied safety precautions, considering masks, 7.4% did not use masks regularly.

CONCLUSION:
Doctors were more prone to COVID-19 infection through COVID-19 duties and emergency room duties; however, during that period, community spread was least reported here; therefore, evaluation of clinical features and associated complications was necessary to actively improve the management and protective measures.
Identification and Determination of the Major Constituents in Xie-Bai-San by Ultra-performance Liquid Chromatography–Mass Spectrometry
Authors: Li Bao-Xin , Li Peng-Yue , Hao Li-Xia , Xue Xiao-Xia , Kong Sha-Sha , Zhao Qin-He , Dai Yun-Tao 
Published: August 2024

Objective:
The ancient classical Chinese formulation, Xie-Bai-San (XBS), was studied qualitatively and quantitatively, and its main components were characterized.

Materials and Methods:
The chemical compounds in XBS were identified using a combination of ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and molecular networking (MN) analysis. In addition, a multiple reaction monitoring (MRM) quantification method was established using ultra-high-performance liquid chromatography–triple quadrupole mass spectrometry. Mulberroside A, kukoamine B, liquiritin, and glycyrrhizic acid were quantitatively analyzed in ten batches of XBS using this method.

Results:
Using clusters of MN and databases, 91 compounds were rapidly identified, including stilbene glycosides, saponins, flavonoids, and alkaloids. Of these, 30, 33, and 28 compounds were from Mori Cortex, Lycii Cortex, and Glycyrrhizae Radix et Rhizoma, respectively. The MRM scanning mode was used for the simultaneous sensitive quantitative determination of multiple components in a wide range of complex samples. The four main components were quantified using this method, which has good linearity.

Conclusions:
This study provides a comprehensive and reliable method for the identification and quantitative analysis of XBS.
Integrated Phytochemical Analysis Based on Ultra-high-performance Liquid Chromatography-mass Spectrometry and Network Pharmacology Approaches to Explore the Bioactive Constituents and Potential Targets of Jiangtang Qingre Formula
Authors: Gao Wen-Ya , Zhang Yan , Zhou Li-Juan , Li Min , Li Tao , Gao Chang , Gao Shuang-Rong , Si Nan , Wei Xiao-Lu , Bian Bao-Lin , Wang Hong-Jie , Zhou Yan-Yan , Zhao Hai-Yu 
Published: August 2024

Objective:
This study aims to elucidate and quantify the composition of Jiangtang Qingre formula (JQF), delineate the absorbed components in the bloodstream, predict the major biologically active components, and identify potential targets for the treatment of diabetes mellitus (DM).

Materials and Methods:
The chemical composition and metabolites of JQF were elucidated using ultra-high-performance liquid chromatography (UHPLC)-linear ion trap quadrupole-orbitrap high-resolution mass spectrometry (MS). The various components of JQF were concurrently determined using UHPLC-triple–quadrupole MS. Network pharmacological analysis was employed to explore the bioactive components and potential therapeutic targets in DM.

Results:
A total of 63 compounds were identified and provisionally characterized, with flavones, organic acids, and alkaloids emerging as the major chemical constituents. A robust analytical method that enables the simultaneous quantification of 24 representative components was successfully developed. The contents of 11 batches of samples were assessed. Ten prototype components were identified in rat plasma. The pathways associated with the efficacy of JQF in DM treatment were linked to signal transduction, endocrine and immune systems, lipid metabolism, and amino acid metabolism.

Conclusion:
This study systematically and comprehensively characterized the major chemical components and patterns in JQF, laying the groundwork for understanding its pharmacodynamic mechanisms and clinical applications.
Stability of a point charge for the repulsive Vlasov–Poisson system
Authors: Pausader Benoît , Widmayer Klaus , Yang Jiaqi 
Published: August 2024

We consider solutions of the repulsive Vlasov–Poisson system which are a combination of a point charge and a small gas, i.e., measures of the form

\delta_{(\mathcal{X}(t),\mathcal{V}(t))}+\mu^{2}d\mathbf{x}d\mathbf{v}

for some

(\mathcal{X}, \mathcal{V})\colon \mathbb{R}\to\mathbb{R}^{6}

and a small gas distribution

\mu\colon \mathbb{R}\to L^{2}_{\mathbf{x},\mathbf{v}}

, and study asymptotic dynamics in the associated initial value problem. If initially suitable moments on

\mu_{0}=\mu(t=0)

are small, we obtain a global solution of the above form, and the electric field generated by the gas distribution

\mu

decays at an almost optimal rate. Assuming in addition boundedness of suitable derivatives of

\mu_{0}

, the electric field decays at an optimal rate, and we derive modified scattering dynamics for the motion of the point charge and the gas distribution. Our proof makes crucial use of the Hamiltonian structure. The linearized system is transport by the Kepler ODE, which we integrate exactly through an asymptotic action-angle transformation. Thanks to a precise understanding of the associated kinematics, moment and derivative control is achieved via a bootstrap analysis that relies on the decay of the electric field associated to

\mu

. The asymptotic behavior can then be deduced from the properties of Poisson brackets in asymptotic action coordinates.
Application of the solitary red mason bee, Osmia rufa L. (syn. O. bicornis), in forest monocultures in Poland
Authors: Kęsy Mateusz 
Published: August 2024

Seed orchards are utilised in forestry to avoid monoculture cultivation in forest areas and also constitute a gene bank for various tree species. In order to meet seed needs, preserve species diversity and genetic resources of forest management of the country, several hundred seed orchards served the purposes in Poland today. The paper presents an innovative solution to increase tree yield by introducing nests of solitary bees Osmia rufa L. (syn. O. bicornis) into monocultures. These insects are a natural solution that allows increasing the yield of selected tree and shrub species, especially fruit trees and shrubs and selected forest species. In order to determine the suitability of Osmia rufa L. to support the seed production process, a several-year research project was pursued consisting in assessing the quality of seeds, bee reproduction and identifying natural populations of insects in forest areas that were already present there before the introduction of bees. The research clearly shows that red mason bee, Osmia rufa L., can be employed with great success in forest areas to increase the productivity of selected forest tree species. Additionally, the work presents the results of study of red mason bee reproduction, showing that these bees in forest areas can also develop properly.
Keywords: seed orchards; Tilia cordata; Quercus petraea; Prunus avium; insects; rearing of bees
Strategi Pencegahan Bunuh Diri di Kalangan Pegawai Negeri pada Polri
Authors: Frans Tjahyono  , Obing Katubi  , Dini Rahma Bintari  
Published: August 2024

Tugas sebagai Pegawai Negeri Pada Polri (PNPP) merupakan pekerjaan yang memiliki tingkat stressing tinggi karena harus selalu berhadapan dengan masalah yang ada di Masyarakat. Dalam satu setengah tahun terakhir, yaitu tahun 2022 ada 8 kasus dan tahun 2023, terhitung baru sampai 23 Juni 2023 sudah terjadi 16 kasus polisi bunuh diri. Pengumpulan data dilakukan dengan penyebaran kuesioner kepada seluruh PNPP di 34 Polda. FGD dengan pejabat utama di Polda dan Polres, serta FGD dengan para PNPP di Polda sampel. Hasil penelitian menunjukkan dari hasil pengisian kuesioner Patient Health Questionnaire-9 (PHQ-9) yang disebarkan ke 34 Polda dan Polres jajaran seluruh Indonesia dapat disimpulkan PNPP yang terdiagnosis depresi berat sebanyak 194 orang dan depresi sedang sebanyak 428 orang. Hasil screening kondisi kesehatan mental khususnya di Polda Metrojaya teridentifikasi anggota Satintelkam Polresta Bandara yang terdiagnosis depresi sedang akhirnya melakukan tindakan bunuh diri, sehingga dari kejadian tersebut perlu segera untuk ditindaklanjuti oleh seluruh jajaran. Rekomendasi yang bisa dijadikan sebagai upaya untuk meningkatan pola dan strategi pencegahan bunuh diri di kalangan PNPP adalah Para pemangku kebijakan harus memberikan perhatian dan layanan intervensi psikologis yang sesuai kepada para PNPP yang Hasil analisis kesehatan mentalnya menunjukkan gejala depresi, terutama yang berkategori sedang dan berat, berkategori permisif/pro terhadap bunuh diri.