bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in adoption of extravascular cardiac implantable electronic devices: the Dutch cohort
Authors: Breeman Karel T. N. , Knops Reinoud E. , van der Stoel Michelle D. , Boersma Lucas V. A. , Yap Sing-Chien , van Erven Lieselot , van Dijk Vincent F. , Maass Alexander H. , Wilde Arthur A. M. , Tjong Fleur V. Y. ,   Device Registration Committee of the Netherlands Heart Registration
Published: August 2024

Abstract
Introduction
Conventional implantable cardioverter-defibrillators (ICDs) and pacemakers carry a risk of pocket- and lead-related complications in particular. To avoid these complications, extravascular devices (EVDs) have been developed, such as the subcutaneous ICD (S-ICD) and leadless pacemaker (LP). However, data on patient or centre characteristics related to the actual adoption of EVDs are lacking.

Objective
To assess real-world nationwide trends in EVD adoption in the Netherlands.

Methods
Using the Netherlands Heart Registration, all consecutive patients with a de novo S‑ICD or conventional single-chamber ICD implantation between 2012–2020, or de novo LP or conventional single-chamber pacemaker implantation between 2014–2020 were included. Trends in adoption are described for various patient and centre characteristics.

Result
From 2012–2020, 2190 S‑ICDs and 10,683 conventional ICDs were implanted; from 2014–2020, 712 LPs and 11,103 conventional pacemakers were implanted. The general use has increased (S-ICDs 8 to 21%; LPs 1 to 8%), but this increase seems to have reached a plateau. S‑ICD recipients were younger than conventional ICD recipients (p < 0.001) and more often female (p < 0.001); LP recipients were younger than conventional pacemaker recipients (p < 0.001) and more often male (p = 0.03). Both S‑ICDs and LPs were mainly implanted in high-volume centres with cardiothoracic surgery on-site, although over time S‑ICDs were increasingly implanted in centres without cardiothoracic surgery (p < 0.001).

Conclusion
This nationwide study demonstrated a relatively quick adoption of innovative EVDs with a plateau after approximately 4 years. S‑ICD use is especially high in younger patients. EVDs are mainly implanted in high-volume centres with cardiothoracic surgery back-up, but S‑ICD use is expanding beyond those centres.
Peri-urban agriculture and household food and nutrition security around Eldoret, Kenya
Authors: Petrikova Ivica , Otieno Melvine Anyango , Were Gertrude , Eltholth Mahmoud , Mateos Ana Rodriguez , Harding Seeromanie , Moran Victoria , Osano Odipo , Cole Jennifer 
Published: August 2024

AbstractRapid urbanisation in low- and middle-income countries, which has encroached on agricultural lands but has not been consistently accompanied by corresponding improvements in water and sanitation services, has raised questions about its impact on the food and nutrition security of households living in transitional, peri-urban areas. Through an analysis of survey data collected from 518 households living around the town of Eldoret, Kenya, we investigate the existing links between peri-urban households’ engagement in agriculture, their dietary behaviour, and their children’s nutrition outcomes. We find that peri-urban households engaged in agriculture, particularly in crop growing and in the sales of their agricultural produce, have more diverse and nutritious diets than agriculturally non-engaged households, all other things being equal. However, a significant improvement in children’s health outcomes is observed in these households only when coupled with improved water, sanitation, and hygiene conditions.
State of the Science: Health Care Provider Communication of Cannabis Use Among Adults Living with Cancer
Authors: Baral Amrit , Diggs Bria-Necole A. , Greengold Judith , Foronda Cynthia , Anglade Debbie , Camacho-Rivera Marlene , Islam Jessica Y. , Vidot Denise C. 
Published: August 2024

AbstractDespite medicinal cannabis gaining popularity for managing symptoms in cancer patients, a knowledge gap exists in patient-provider communication crucial for monitoring outcomes, optimizing dosing, and educating healthcare providers to integrate cannabis into treatment plans. Our goal is to understand communication dynamics, identify gaps, and pave the way for effective cannabis communication for individuals living with cancer (PLWC). We searched PubMed, CINAHL, and EBSCO for articles published between 2013 and July 2023, capturing the key concepts of cannabis use in cancer patients and their communication with healthcare providers in oncology settings. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guided the review. Studies were appraised by applying the Johns Hopkins Evidence-Based Practice Model for Nursing and Healthcare Professionals. Of the 2384 articles reviewed, 14 met the inclusion criteria. Three were qualitative studies, and 11 were cross-sectional surveys. All studies were level III evidence. Studies captured patients’ and providers’ perspectives; five were conducted among cancer patients, and nine were among healthcare providers in oncology settings. Findings revealed variations in healthcare provider recommendations, patient-initiated discussions, and barriers to discussing medical cannabis (MC). The synthesis of this evidence highlights the complexities surrounding MC in oncology settings, including knowledge gaps among healthcare providers, patient-initiated discussions, and challenges in accessing and prescribing medicinal cannabis. This review contributes valuable insights into the current landscape of MC use in cancer care, emphasizing the need for improved communication, education, and support for both patients and healthcare providers.
A rate-responsive duty-cycling protocol for leadless pacemaker synchronization
Authors: Ryser Adrian , Reichlin Tobias , Burger Jürgen , Niederhauser Thomas , Haeberlin Andreas 
Published: August 2024

AbstractDual-chamber leadless pacemakers (LLPMs) consist of two implants, one in the right atrium and one in the right ventricle. Inter-device communication, required for atrioventricular (AV) synchrony, however, reduces the projected longevity of commercial dual-chamber LLPMs by 35–45%. This work analyzes the power-saving potential and the resulting impact on AV-synchrony for a novel LLPM synchronization protocol. Relevant parameters of the proposed window scheduling algorithm were optimized with system-level simulations investigating the resulting trade-off between transceiver current consumption and AV-synchrony. The parameter set included the algorithm’s setpoint for the target number of windows per cardiac cycle and the number of averaging cycles used in the window update calculation. The sensing inputs for the LLPM model were derived from human electrocardiogram recordings in the MIT-BIH Arrhythmia Database. Transceiver current consumption was estimated by combining the simulation results on the required communication resources with electrical measurements of a receiver microchip developed for LLPM synchronization in previous work. The performance ratio given by AV-synchrony divided by current consumption was maximized for a target of one window per cardiac cycle and three averaging cycles. Median transceiver current of both LLPMs combined was 166 nA (interquartile range: 152–183 nA) and median AV-synchrony was 92.5%. This corresponded to median reduction of 18.3% and 3.2% in current consumption and AV-synchrony, respectively, compared to a non-rate-responsive implementation of the same protocol, which prioritized maximum AV-synchrony. In conclusion, adopting a rate-responsive communication protocol may significantly increase device longevity of dual-chamber LLPMs without compromising AV-synchrony, potentially reducing the frequency of device replacements.
Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products
Authors: Tembeni Babalwa , Idowu Olusola Emmanuel , Benrkia Rachid , Boutahiri Salima , Olatunji Opeyemi Joshua 
Published: August 2024

AbstractBiotransformation is a process in which molecules are modified in the presence of a biocatalyst or enzymes, as well as the metabolic alterations that occur in organisms from exposure to the molecules. Microbial biotransformation is an important process in natural product drug discovery as novel compounds are biosynthesised. Additionally, biotransformation products offer compounds with improved efficacy, solubility, reduced cytotoxic and allows for the understanding of structure activity relationships. One of the driving forces for these impeccable findings are associated with the presence of cytochrome P450 monooxygenases that is present in all organisms such as mammals, bacteria, and fungi. Numerous fungal strains have been used and reported for their ability to biotransform different compounds. This review focused on studies using Alternaria species as biocatalysts in the biotransformation of natural product compounds. Alternaria species facilitates reactions that favour stereoselectivity, regioselectivity under mild conditions. Additionally, microbial biotransformation products, their application in food, pharmaceutical and agricultural sector is discussed in this review.
Graphical Abstract
Experimental Comparison of Glazed and Unglazed Hybrid Solar Modules Considering Power Productivity and Cell Temperature
Authors: Alshibil Ahssan M.A. , Farkas István , Víg Piroska 
Published: August 2024

AbstractThis study presents the effect of cell temperature on the hybrid solar collectors PV/T for modules with and without using a front glass cover. A numerical model of thermal behaviour was carried out for glazed (PV/Tg ) and unglazed (PV/Tun) modules. As a result of this experimental investigation conducted for presented PV/T modules, a sufficient decrease in the cell temperature of PV/Tun compared to the PV/Tg, PV/Tun module exceeded the PV/Tg by 19%. Thus, the electrical productivity of the PV/Tun module was higher; it was 3.44% higher than the PV/Tg value. The outlet liquid temperature of the un-covered module was 6.34% higher than the outlet liquid temperature of the glass-covered module. Besides, the total efficiency of the PV/Tg was higher during the periods of study. In this sense, the glass-covered module is preferable for applications that deal with overall efficiency as a desirable factor. The un-covered module is much beneficial for applications that need high electrical productivity.
Eye-tracking contribution on processing of (implicit) reading comprehension
Authors: de-la-Peña Cristina 
Published: August 2024

AbstractReading comprehension is a fundamental skill to be developed from the early stages of reading acquisition and it is essential for both formative and personal learning. This study examines eye-tracking as a useful and complementary tool in the assessment and improvement of implicit reading comprehension. The aim is to understand the role of eye-tracking in implicit reading comprehension and, complementarily, in intervening skills such as vocabulary, rapid automatized naming, and processing speed. In a final sample of 7–8 year-old 67 students, tests for implicit reading comprehension (literal, inferential, and total), eye-tracking measures, vocabulary, rapid automatized naming, processing speed, as well as tests to control for intellectual and attentional levels were administered. The results of the correlational and regression analyses indicate the existence of predictive relationships between (i) implicit reading comprehension and eye-tracking measures, and additionally, (ii) between intervening skills (vocabulary, rapid automatized naming, processing speed) and eye-tracking measures, and (iii) between implicit reading comprehension and intervening skills (vocabulary, rapid automatized naming, processing speed). In summary, better performance in implicit reading comprehension (literal, inferential, and total) is related to and explained by shorter eye movement times in recognition and access to meaning, larger vocabulary, and faster rapid automatized naming and processing speed. Furthermore, eye-tracking measures are better predictors of implicit reading comprehension. These findings provide promising evidence for the contribution of eye-tracking to optimising the level of implicit reading comprehension, which is applied daily in classrooms.
Promoting global alliances for sustainable architectural education, training, and practice in Nigeria
Authors: Okonta Ebere Donatus , Ayinla Oluwaseun Ayodapo 
Published: August 2024

AbstractThe field of architecture in Nigeria is experiencing dynamic growth and development, driven by urbanisation, infrastructure demands, and a growing awareness of sustainability. To navigate these challenges and contribute to sustainable development, the study aimed to explore the potential of global alliances that enhance architectural education, training and professionalism. The study combines literature reviews, six case studies of successful international architectural alliances and 34 interviews with architectural professionals to explore the significance of promoting global alliances for sustainable architectural training, practice, and profession in Nigeria. The findings suggest that many countries, like the United Kingdom, Australia, New Zealand, Canada, the United States of America, and Hong Kong, have formed alliances with architectural regulatory bodies in other nations to simplify international architectural practice. The benefits of a global architectural alliance enable architects to practice worldwide, promoting reciprocity and enhancing competitiveness and professional enhancement. Such alliances enrich architectural education, fostering the development of well-rounded professionals capable of addressing the complex challenges of the built environment. This research provides valuable insights for architectural education, training, and professional stakeholders seeking to elevate sustainable development in Nigeria. By cultivating global alliances, Nigeria can develop a thriving architectural landscape that addresses societal challenges, preserves cultural heritage, and leads the way in sustainable architectural practices.
Joint Occurrence of Extreme Water Level and River Flows in St. Lawrence River Coasts Under Present and Sea Level Rise Conditions
Authors: Bizhanimanzar Mohammad , Rondeau‐Genesse Gabriel , Caron Louis‐Philippe , Lefaivre Denis , Mailhot Edouard 
Published: August 2024

AbstractIn low‐lying coastal regions, the joint occurrence of high river flow and high water levels can cause coastal flooding with substantial economic and social implications. Recent studies over Canada's coasts have shown that neglecting the interdependency between flood drivers can underestimate the risk of flooding by up to 50%. However, to date, such interdependency has not been investigated for the coasts of the St. Lawrence River, Estuary and Gulf system (StL), where Sea Level Rise (SLR), along with intensified river peaks, are already threatening these communities. In this study, a copula‐based bivariate frequency analysis was applied to quantify the likelihood of occurrence of flooding events under dependent and independent assumptions, for 26 sites along the StL. Furthermore, to quantify the impact of anthropogenic climate change, the joint return period in historical period was compared with that of projected SLR associated with RCP 8.5 for the year 2100. Results show that (a) the independence assumption can underestimate the likelihood of occurrence of flooding event in the Fluvial Section of the StL by up to 30 times and (b) the SLR can increase the likelihood of occurrence of flooding event by up to 50 times in the Estuary and the Gulf and by up to 5 times in the Fluvial Section of the StL. This study highlights the need for explicit consideration of the dependence between flood drivers and of SLR in the delineation of flood maps along the coast of the St. Lawrence.
Strong pCO2 Undersaturation in an Arctic Sea: A Decade of Spatial and Temporal Variability in Baffin Bay
Authors: Nickoloff G. , Else B. G. T. , Ahmed M. , Burgers T. M. , Miller L. A. , Papakyriakou T. 
Published: August 2024

AbstractUtilizing an 11‐year (2011–2021) data set, we report surface‐ocean pCO2 in Baffin Bay during the open‐water season (June–October) to establish a baseline understanding of surface seawater carbon dynamics in this region. We found pCO2 was strongly undersaturated (70–130 μatm below saturation, depending on year), albeit with substantial regional variability. Though temperature was found to be a generally strong control of pCO2, sea‐ice dynamics and other non‐thermal drivers controlled pCO2 at certain times and in certain regions. The Baffin Island Current region (western Baffin Bay) experienced relatively high pCO2 during instances of high sea‐ice cover, usually in early spring. Average pCO2 was comparatively lower in the West Greenland Current region (eastern Baffin Bay) which is ice‐free substantially longer (by 3–4 months) and where temperature acted as the dominant control to pCO2. With respect to temporal variations, June had the lowest pCO2 of the open‐water season, coinciding with active sea‐ice melt. Surface‐ocean pCO2 then increased month‐to‐month through July and August due to warming and decreased meltwater dilution, increasing again into September before stabilizing into October. Generally, non‐thermal controls acted to decrease pCO2 during mid‐summer (possibly primary production, sea‐ice melt, and circulation), but acted to increase pCO2 during early fall (vertical mixing). Despite spatial and temporal variation over the open‐water season, persistent undersaturation suggests that Baffin Bay is a potentially strong CO2 sink, even in comparison to other uptake regions across the western Arctic.
Bedrock Controls on Water and Energy Partitioning
Authors: Ehlert Robert S. , Hahm W. Jesse , Dralle David N. , Rempe Daniella M. , Allen Diana M. 
Published: August 2024

AbstractAcross diverse biomes and climate types, plants use water stored in bedrock to sustain plant transpiration. Bedrock water storage (Sbedrock), in addition to soil moisture, thus plays an important role in water cycling and should be accounted for in the context of surface energy balances and streamflow generation. Yet, the extent to which bedrock water storage impacts hydrologic partitioning and influences latent heat fluxes has yet to be quantified at large scales. This is particularly important in Mediterranean climates, where the majority of precipitation is offset from energy delivery and plants must rely on water retained from the wet season to support summer growth. Here we present a simple and modified water balance approach to quantify the role of Sbedrock on controlling hydrologic and energy partitioning. Specifically, we tracked evapotranspiration in excess of precipitation and mapped soil water storage capacity (Ssoil, mm) across the western US in the context of Budyko's water partitioning framework. Our findings indicate that Sbedrock is necessary to sustain plant transpiration across forests in the Sierra Nevada—some of the most productive forests on Earth—as early as April every year, which is counter to the current conventional thought that bedrock is exclusively used late in the dry season under extremely dry conditions. We found that the proportion of water that returns to the atmosphere would decrease dramatically without access to Sbedrock. When converted to latent heat energy, the median monthly flux associated with evapotranspiration of Sbedrock can exceed 100 W/m2 during the dry season.
Development of Functional Quantile Autoregressive Model for River Flow Curve Forecasting
Authors: Mutis Muge , Beyaztas Ufuk , Simsek Gulhayat Golbasi , Shang Han Lin , Yaseen Zaher Mundher 
Published: August 2024

AbstractAmong several hydrological processes, river flow is an essential parameter that is vital for different water resources engineering activities. Although several methodologies have been adopted over the literature for modeling river flow, the limitation still exists in modeling the river flow time series curve. In this research, a functional quantile autoregressive of order one model was developed to characterize the entire conditional distribution of the river flow time series curve. Based on the functional principal component analysis, the regression parameter function was estimated using a multivariate quantile regression framework. For this purpose, hourly scale river flow collected from three rivers in Australia (Mary River, Lockyer Valley, and Albert River) were used to evaluate the finite‐sample performance of the proposed methodology. A series of Monte‐Carlo experiments and historical data sets were examined at three stations. Further, uncertainty analysis was adopted for the methodology evaluation. Compared with the existing methods, the proposed model provides more robust forecasts for outlying observations, non‐Gaussian and heavy‐tailed error distribution, and heteroskedasticity. Also, the proposed model has the merit of predicting the intervals of future realizations of river flow time series at the central and non‐central locations. The results confirmed the potential for predicting the river flow time series curve with a high level of accuracy in comparison with the benchmark existing functional time series methods.
Volatiles and Redox Along the East African Rift
Authors: Brounce Maryjo , Scoggins Sara , Fischer Tobias P. , Ford Heather , Byrnes Joseph 
Published: August 2024

AbstractThe upper mantle under the Afar Depression in the East African Rift displays some of the slowest seismic wave speeds observed globally. Despite the extreme nature of the geophysical anomaly, lavas that erupted along the East African Rift record modest thermal anomalies. We present measurements of major elements, H2O, S, and CO2, and Fe3+/ΣFe and S6+/ΣS in submarine glasses from the Gulf of Aden seafloor spreading center and olivine‐, plagioclase‐, and pyroxene‐hosted melt inclusions from Erta Ale volcano in the Afar Depression. We combine these measurements with literature data to place constraints on the temperature, H2O, and fO2 of the mantle sources of these lavas as well as the initial and final pressures of melting. The Afar mantle plume is C/FOZO/PHEM in isotopic composition, and we suggest that this mantle component is damp, with 852 ± 167 ppm H2O, not elevated in fO2 compared to the depleted MORB mantle, and has temperatures of ∼1401–1458°C. This is similar in fO2 and H2O to the estimates of C/FOZO/PHEM in other locations. Using the moderate H2O contents of the mantle together with the moderate thermal anomaly, we find that melting begins at around 93 km depth and ceases at around 63 km depth under the Afar Depression and at around 37 km depth under the Gulf of Aden, and that ∼1%–29% partial melts of the mantle can be generated under these conditions. We speculate that the presence of melt, and not elevated temperatures or high H2O contents, are the cause for the prominent geophysical anomaly observed in this region.