bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visible Light Promoted Catalyst Free, the Sustainable Synthesis of Dihydropyrano [2,3-C] Pyrazoles and Docking Studies with COVID-19 Mpro
Authors: REHAN MOHD , . Shafiullah 
Published: July 2024

A highly efficient, simple, cost effective, and eco-friendly protocol has been developed for synthesis of dihydropyrano[2,3-c]pyrazoles via one-pot, three-component condensation of 3-methyl-1-phenyl-2-pyrazoline-5-one, malononitrile, substituted aromatic aldehydes under visible light irradiation in catalyst-free condition at room temperature. The main advantage of this methodology is good to excellent yield, simple work-up procedure, mild and clean reaction conditions, no chromatographic separation, environmentally benign reaction conditions, and catalyst free, the application of clean visible-light as a source of energy. The synthesized compounds are screened in silico with 6LU7, which is a COVID-19 Mpro. Compound 4i and nitro group compounds 4d, 4e, 4f are showing strong correlation at the active center of 6LU7. So, it is predicted that these compounds may be useful for COVID-19 patients.
IN-VIVO EVALUATION OF FLUVASTATIN LOADED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS
Authors: Padmaganesh Bommareddy Srinivasa , Bhikshapathi Darna 
Published: July 2024

The present work is aimed at formulation of fluvastatin SNEDDS, its optimization using Box-Behnken Design (BBD) followed by in-vitro and in-vivo evaluation. The SNEDDS formulation comprising 30% sefsol 218, 50% cremophor RH40 and 35% propylene glycol choosen optimal with maximum drug release of 98.62% when compared to pure drug (13.76 %). The formulations evaluated for physic-chemical parameters and results were found within the acceptable limits. The in vivo pharmacokinetic study conducted on Wistar rats indicate that drug plasma concentration in rats administrated with fluvastatin SNEDDS was higher than that of animals treated with fluvastatin. Cmax of the SNEDDS (699.972±2.85 ng/ml) was found significant (p<0.05) when compared to that of pure drug (225.7±0.57 ng/ml).Tmax of both fluvastatin SNEDDS and pure drug were 50±0.53 and 75±0.72 minutes. The AUC0-∞and AUC0-t of SNEDDS was higher than the pure drug indicating higher drug concentrations in blood resulting in systemic absorption of fluvastatin from developed SNEDDS.
Comparative Study of Anti-Inflammatory Activity of Two Formulations of Jatyadi Thailam In Vitro on Raw264.7 Macrophages and its Dual Inhibitor Role of 5-Lipoxygenase and Cyclooxygenase
Authors: Swathi Kandasamy , Sumathi Sundaravadivelu 
Published: July 2024

Jatyadi thailam is traditional formulation widely used to treat chronic wounds. Reverse pharmacology approach is employed to study the mode of action of two traditional formulations of thailam-AFI Jatyadi thailam (JT-AFI) and Jatyadi thailam-Yogagrantha (JT-YG) against radicals DPPH, ABTS, Nitric oxide, hydroxyl, and superoxide radicals and inflammatory mediators in vitro, namely Nitric oxide, 5-Lipoxygenase and cyclooxygenase-1, and cyclooxygenase-2. Both formulations of Jatyadi thailam rendered dose-dependent inhibition of free radicals and demonstrated their reduction potential.. The free radical formation is inextricably associated to the inflammatory process. The formulations significantly reduced nitrite at its highest concentration in LPS-induced RAW264.7 macrophage cells. The formulations also unveiled subsequent dose-dependent inhibition of 5-Lipoxygenase, Cyclooxygenase-1, and Cyclooxygenase-2 enzymes. JT-AFI proved to be a selective inhibitor for COX-2 with a COX-1/COX-2 ratio of 1.924, while JT-YG was COX-1 selective (0.794). The study's outcome indicated that JT-AFI exhibited superior antioxidant and anti-inflammatory activities than JT-YG. The current investigation could shed insights on the scientific validation of the use of Jatyadi thailam in chronic wound management.
Synthesis and Evaluation for Anxiolytic activity of some substituted Dihydropyrazolyl- thiazoline-4-one derivatives
Authors: Rishipathak Dinesh , Raut Manisha 
Published: July 2024

Anxiolytic drugs are used for the treatment of anxiety disorders and their related psychological and physical symptoms. Today's increase in anxiolytic drug resistance has resulted in serious health issues. Thus, there is an ever-increasing demand for the design and synthesis of newer drugs for treatment. The present work reports the synthesis of some derivatives of pyrazolyl thiazolino-4-one viz. 2-[3-(furan-2-yl)-5-substituted phenyl-4,5-dihydro-1H-pyrazole-1-yl]-1,3-thiazole-4(5H)-ones. Six derivatives have been synthesized and the chemical structures were confirmed by IR, H1-NMR, and 13C-NMR. All the compounds were subjected to toxicity studies and then evaluated for their anxiolytic activity using elevated plus maze apparatus on rats. LD50 was found to be 98.11 mg/Kg. An increase in the percentage of time spent and the number of entries in the open arm of the plus maze signals a good potential for minimizing anxiety in rats. All the results were statistically tested by one-way ANOVA followed by Dunnett’s test. Compound 2; 2-[3-(furan-2-yl)-5-(4-dimethylamino- phenyl)- 4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one and Compound 5; 2-[3-(furan-2-yl)-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one have shown percentage preference to open arm as 15.11 and 14.17 seconds and average time spent in open arm as 45.33 and 42.50 seconds respectively and thus resulted in significant anxiolytic effect as compared to control. These compounds can serve as potential leads for the development of newer therapeutic agents for the treatment of anxiety.
تأثير تمرينات خاصة بالقوة المميزة بالسرعة والمناولة بالجــــــــزء الداخلي الامامي للقدم لتطوير دقة تهديف الكرات الثابته لدى لاعبي كرة القـدم الناشئين
Authors: احمد قادر هيوا 
Published: July 2024

الخلاصة
كرة القدم من الألعاب التي اعتمدت بشكل ملحوظ على تنوع المهارات المستخدمة اثناء شوطي المباراة فضلا عن حاجة اللاعبين كافراد وكمجموعة وبشكل دائم الى دقة تنفيذ هذه المهارات , مهارة تهديف الكرات الثابته تعد عاملا ذا اهمية قصوى لاجل تسجيل الاهداف وتحقيق الفوز في المباريات وهذا ما دفع الباحث الى دراسة استخدام تمرينات خاصة بالقوة المميزة بالسرعة و المناولة بالجزء الداخلي الامامي للقدم للتعرف على تاثيرها على دقة تسجيل الاهداف من الكرات الثابتة لدى لاعبي كرة القدم الناشئين وهنا تكمن أهمية البحث , تتمثل عينة البحث بلاعبي اكاديمية جلولاء الرياضية بكرة القدم لفئة الناشئين المعد للمشاركة في بطولة المحافظة للموسم 2023-2024 والبالغ عددهم (24) لاعبا , تم ابعاد (4) لاعبين عن التجربة لالتزامهم بالامتحانات الوزارية للمرحلة المتوسطة الدور الثاني , قام الباحث بترتيب اللاعبين تنازليا حسب نتائج اختبار مهاري من ثم تم تقسيمهم الى مجموعتين بطريقة المزاوجة بـ (10) لاعبين لكل مجموعة , وعن طريق القرعة تم تحديد المجموعة التجريبية والمجموعة الضابطة , استنتج الباحث ان التدريب على تمرينات خاصة بالقوة المميزة بالسرعة لعضلات الساقين وتمرينات المناولة بالجزء الداخلي الامامي للقدم ادت الى تطور في دقة تهديف الكرات الثابتة لدى افراد المجموعة التجريبية, وخرج الباحث بمقترحات خاصه بموضوع البحث.
BLOCKCHAIN TECHNOLOGY UNDER THE LENS OF SOCIAL INNOVATION: ILLUSTRATING DIMENSIONS AND ELEMENTS IN A SOCIAL FINTECH
Authors: Loiola Ricardo Alan Kardec , Lazáro José Carlos , Neutzling Daiane Mulling , Leocadio Aurio Lucio 
Published: July 2024

Objective: This article is intended to demonstrate how the use of Blockchain by a Social Fintech can be viewed under the lens of the Social Innovation construct and its elements (dimensions).

Theoretical Framework: The configuration of the elements (dimensions) was based on studies by Tardif and Harrisson (2005), Cloutier (2003) and André and Abreu (2005), according to the model of Souza, Lessa and Lazaro (2019).

Method: The study was descriptive and exploratory. The case study method was applied with content analysis. The initial inductive analyzes made three dimensions for social innovation emerge more clearly: the Character component, Social Innovativeness and Transformation.

Results and Discussion: We came to the conclusion that access to credit using Blockchain technology to fulfill a social demand values territorial specificities through the organization and mobilization of excluded groups and territories, and helps in altering behavior, attitudes or perceptions.

Research Implications: The role of this research for the area of study shows the dimensions of social innovation as a tool for analyzing a social enterprise. Further investigation with more depth in other settings and evaluating the results is essential for this field. New Social Fintechs are continually emerging. Within this environment, economic models are being transformed as they seek a way to break down barriers in the most adversarial models of society by using blockchain technology.

Originality/Value: The relevance of this research is related to the role of improving the concept and practices of social innovation and the development of initiatives geared towards social economic inclusion.
Workshop Implementasi Kurikulum Merdeka Belajar Di Sekolah Dasar Dan Evaluasi Pembelajaran Tatap Muka Terbatas (PTMT) Di Masa Endemi Terhadap Hasil Belajar Siswa Sekolah Dasar
Authors: Azis Dede Abdul , Arrahim Arrahim Arrahim , Budianti Yudi Budianti , Sundari Kori Sundari , Aningsih Aningsih Aningsih , Sugiharti Rini Endah , Rikmasari Rima Rikmasari 
Published: July 2024

Pengabdian Kepada Msyarakat ini memiliki latar belakang yang dialami oleh mitra bahwa (1) minimnya kompetensi guru dalam mengimpelemntasikan kurikulum merdeka dan evaluasi terhadap pertemuan tatap muka terbatas (PTMT), (2) kurangnya kemapuan guru dalam membuat perangkat pembelajaran berbasis kurikulum merdeka dan Evaluasi terhadap PTMT, (3) kurang mampunya guru, staf dan kepala sekolah dalam menerapkan kurikulum merdeka dis ekolah dasar, (4) adanya kendala dalam membuat desain pembelajaran yang menarik berbasis kurikulum merdeka. Alternatif solusi yang diberikan dan dilakukan melalui kegiatan pengabdian kepada msyarakat ini adalah mengadaan Workshop untuk mengimpelementasikan kurikulum merdeka dan evaluasi Pembelajaran Tatap Muka Terbatas (PTMT) bagi Guru, Staf dan Kepala Sekolah SDN Sukamaju 01 Desa Sukamaju Kecamatan Tambelang Kabupaten Bekasi. Target luaran pengabdian ini berupa perantara pengadaan Pelatihan dan bimbingan strategi implementasi kurikulum merdeka serta pembuatan perangkat pembelajaran, desain pembelajaran berbasis kurikulum merdeka untuk Guru, staf, dan Kepala Sekolah. Metodologi pengabdian ini berupa diskusi, ceramah, problem based learning dan simulasi/prakterk. Hasil pengabdian kepada masyarakat yang telah dilaksanakan berupa memberikan pemahaman dan pengintegrasian dalam menginplementasikan secara bersama kurikulum merdeka dan penggunaan beberapa tools seperti Canva, Az Screen Recorder, Andromo untuk membuat dan mendesain perangkat pembelajaran berbasis kurikulum merdeka yang nanti akan digunaan oleh Guru ketika proses pembelajaran.
Performance Measurement of Outbound Logistics in the Fertilizer Industry for Distribution Activities Based on Performance Of Activity (POA) Model and Analytical Hierarchy Process(AHP) Method
Authors: Rizky Anggraini Della Afi , Farida Pulansari  , Nur Rahmawati  
Published: July 2024

This research presents problems in the fertilizer industry with the goal of knowing the performance of fertilizer distribution. The outbound logistics process in fertilizer distribution activities is important, because it is connected to the process of delivering fertilizer products to consumers. However, in carrying out fertilizer distribution activities, there are problems that occur due to the mismatch of warehouse capacity over storage and differences in estimated delivery time. This situation results in missed fertilizer supplies for consumers. This research uses KPI criteria based on the Performance Of Activity (POA) model and performance weighting with the Analytical Hierarchy Process (AHP) method to determine the value of the Company's outbound logistics performance. The discussion with company experts resulted in 12 KPI indicators based on POA criteria consisting of cost, time, capacity, capability, productivity, utility, and outcome. After weighting with the AHP method, the total outbound logistics performance of 85,918 is included in the good category and can still be improved in the excellent category by giving recommendations for improvement. So, further research can be made collaborating the AHP method with other methods such as the SCOR method to simplify the selection of supply chain process activities or using the Fuzzy AHP method to reduce the subjectivity of the research.
Saúde mental e dimensões da vivência acadêmica de estudantes universitários da Universidade Federal da Bahia, Brasil
Authors: Oliveira Rafael Anunciação , Carmo Maria Beatriz Barreto do , Véras Renata Meira 
Published: July 2024

A Vivência Acadêmica em Psicologia, composta por cinco dimensões, refere-se ao conjunto de experiências e aspectos socioemocionais vivenciados pelos estudantes durante a sua trajetória na Universidade. Nessa perspectiva, este estudo quantitativo, de corte transversal, do tipo analítico exploratório, objetivou realizar o levantamento e descrever as dimensões da Vivência Acadêmica de graduandos dos campi da Universidade Federal da Bahia em 2021. A coleta de dados consistiu na aplicação dos instrumentos: Questionário Socioeconômico-demográfico e o Questionário de Vivências Acadêmicas na sua versão reduzida (QVA-r), com escala Likert de 5 pontos. Como resultados, participaram deste estudo 509 graduandos, sendo 367 (71,2%) do gênero feminino e 142 (27,9%) do gênero masculino, com idade média de 24,06 anos (DP=6,56). Os resultados evidenciam ainda, após serem submetidos às análises quantitativas, que a dimensão Carreira exerce um papel importante para os estudantes (M=3,77; DP=0,73).
Implementasi Etnopedagogi Pada Tradisi Adat Suku Sasak
Authors: Asri Indra Himayatul , Lestarini Yuniar , Muspita Zalia , Sulastri Andi , Kudsiah Musabihatul , Fadilah Dina , Rohini Rohini 
Published: July 2024

Indonesia has a colorful culture, thousands of tribes with their own characteristics, including the Sasak tribe on Lombok Island which has a very unique cultural style. Therefore, it is very possible to explore the educational values ​​contained in the traditions that are still carried out by the people of Lombok which are based on religious values ​​and norms (religion) and based on communal conventions (agreements) which are better known as the Sasak tribe community (Sasak custom). Sasak society is a social group in which spiritual and structural relationships occur which enable the formation of long-term agreements and shared beliefs which are called culture. The Sasak people are a society that still adheres to its culture to this day. Currently, the Sasak tribe is not only a community group but also an ethnic group that adds to the rich traditions of the Indonesian people. One of the Sasak tribal traditions whose educational value can be seen is the Bale (house) and the Nyongkolan tradition.
Keywords: Sasak tribe, Bale, Nyongkolan
DIALEK BAHASA JAWA NGOKO DESA SITIMULYO KECAMATAN PUCAKWANGI DAN DESA DUKUHMULYO KECAMATAN JAKENAN KABUPATEN PATI
Authors: Jumamik Jumamik , Hartati Umi 
Published: July 2024

This study aims to identify the shape ngoko vocabulary and use of particle shape in Javanese dialect Sitimulyo village subdistrict and village Pucakwangi Dukuhmulyo District of Jakenan Pati. This research is descriptive qualitative. The type of this research is descriptive qualitative. Source of data in this research is utterance (oral) which transcribed into writing. The data of this study is the use of the Java language that contain ngoko variations in vocabulary and forms particles that are spoken by indigenous peoples who live in the District Pucakwangi Sitimulyo village and sub-district village Â Jakenan Â dukuhmulyo Pati. Methods of data collection in this study was conducted using Â ably Â involved Â refer, Â recording technique and record engineering. Analysis of the data using the unified method, this method beyond the means of determining the relevant language. Exposure method of data analysis results using informal methods. The results of this study are vocabulary ngoko form and shape of particles using the Â Java Â language dialect sentence in the District Pucakwangi Sitimulyo village and sub-district village Jakenan Â dukuhmulyo Â Pati. Forms of Â Javanese dialect vocabulary ngoko Sitimulyo village and sub-district village Pucakwangi dukuhmulyo Jakenan Pati District of experiencing symptoms of phonetic sounds and Â morphological variation when compared with standard Java language. Variations of the phonetic sounds of symptoms in the form of 1) Change the sound, 2) Removal of phonemes, 3) addition of phonemes. Symptoms include morphological Â affixation form: prefiksasi, sufiksasi, konfiksasi. The use of particle Â shape Â in Â Javanese Â dialect Sitimulyo village subdistrict and village Pucakwangi dukuhmulyo Pati District of Jakenan namely: particle Â softeners, complementary particles, particles priority.
PENINGKATAN KETERAMPILAN MENDENGARKAN DENGAN PEMBELAJARAN TIPE JIGSAW SISWA KELAS XI IPA 1 SMA NEGERI 1 PLERET BANTUL TAHUN AJARAN 2012/2013
Authors: Ermawati Ermawati , Rochmiyati Siti 
Published: July 2024

The purpose of this research is to describe the result of the students listening short story ability and to describe the student's activities by usingÂ Jigsaw learning Method. This research belongs to Class Action Research. The Subject of this study are the science students 1 grade XI of State Senior High School 1 of Pleret Bantul in academic year 2012/2013 and there are the amount of 29 students. This research is conducted in two actions cycle. In this research, the writer used instruments to measure the learning goal of students listening abilities are quiz and observation worksheet to describe the students learning activity. The result of this research shows that (1) Jigsaw type can improve the students listening ability. The improvement of the student's ability in listening short story can be seen from the short story identification understanding and KKM achievement outcome in each cycle. Understanding of short story identification in theme increase 7%, from 75% in cycle I become 82% in cycle II. Understanding of characters identification increase 14%, from 79% in cycle I become 93% in cycle II. Understanding of plot identification increase 14%, from 68% in cycle I become 82% in cycle II. Understanding of setting identification increase 5%, from 85% in cycle I become 90% in cycle II. The result of KKM achievement can be seen by the improvement of student success in listening a short story. KKM achievement in 18 students (62%) who succeed in precycle, increase 3 students (10%) become 21 students (72%) who succeed in the cycle I and increase 8 students (25%) become 29 students (100%) get succeed in cycle II. Jigsaw type can increase the student learning activity. Percentage average of the student's activity increases 20% from 41% in precycling become 61% in cycle I and increase 25% become 86% in cycle II.
KLAUSA KONSESIF DALAM KALIMAT MAJEMUK BERTINGKAT BAHASA INDONESIA
Authors: Sumiyanto Sumiyanto , Mukhlish Mukhlish 
Published: July 2024

The purposes of this research are (1) to describe the kinds of conjunctions of conses clauses in complex sentences of Indonesian, (2) to describe the structures of syntactic function of conses clauses in complex sentences of Indonesian, (3) to describe the syntactic categories of predicate filler of conses clauses in complex sentences of Indonesian, (4) to describe the dissipation of syntactic function that happened on conses clauses in complex sentences of Indonesian. This type of research is qualitative. The method used in data preparation is listening through note technique. The data analysis method used is an attributable method that includes direct elements techniques, change technique, expand techniques, and insertion techniques. The result presentation method of data analysis in this research is done with formal and informal methods. The research results of conses clauses in complex sentences of Indonesian are as follows. (1) The kinds of conjunctions on konsesif clauses in complex sentences are meski(pun), walau(pun), kendati(pun), sekalipun, betapapun, biarpun, apa pun, and ke mana pun. (2) The structures of syntactic function of conses clauses in complex sentences of Indonesian are (a) = â€¦ KetÂ Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â ,Â (b) = â€¦ KetÂ Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â ,Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Konj Kons+S+P(+O)(+Pel)(+Ket)Â Â Â Â Â Â Â Â Â Â Â Â Â Â Konj Kons+S+Ã˜dan (c) = â€¦ KetÂ Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â .Â Â (3) The syntactic categories of predicate fillerÂ Â Â Â Â Â Â Â Â Â Konj Kons+Ã˜+P(+O)(+Pel)of conses clauses in complex sentences of Indonesian include (a) the conses clauses of the verbal predicate,(b) the conses clauses of the adjectival predicate, (c) the conses clauses of the nominal predicate, (d) the conses clauses of the numeral predicate, and the conses clauses of a prepositional phrase. (4) The dissipation of syntactic functions that happened on conses clauses in complex sentences of Indonesian is subject and predicate dissipation.
SOSOK KELUARGA PEJUANG DALAM NOVEL IBUK KARYA IWAN SETYAWAN: TINJAUAN PSIKOLOGI SASTRA
Authors: Sari Indah Puspito , Dermawan Rusdian Noor 
Published: July 2024

The purpose of this study was to describe (1) character and characterization, (2) setting, (3) planting values in the family, and (4) figures of family fighters in the novel Ibuk. Â The research was a qualitative research. The research data was qualitative data in the form of units of a paragraph or events in the novel Ibuk by Iwan Setiawan. The primary data source was the novel Ibuk by Iwan Setiawan published by PT. Gramedia Pustaka Utama Jakarta in 2012. The research instrument was a researcher herself that was equipped with a set of theories about the characters and characterizations, setting, cultivation of values, theory of literature and family psychology. Data collection methods were reading, recording, and literature. Data analysis methods were using qualitative descriptive. The results of the research are as follows. (1) The main character in the novel Ibuk is Ngatinah (Ibuk), while the subordinate figures are Mr, Bayek, Isa, Nani, and Rini. Ngatinah (Ibuk) is referred as the main character because she is the character most involved with the theme of the story, most interact with other characters and most take storytelling. Ngatinah character is depicted as a firm leader, responsible, humble, and patient. (2) In the novel Ibuk, setting the time, place, and the social culture is in it. Setting time shows a state that occurs by day, month, and year of occurrence. The setting of place occurs in the market, Batu Malang, Bogor, Surabaya, Karawang, and New York. The social setting takes place in the setting of social class or lower middle-level social class. (3) Investment value in the novel Ibuk family consists of (a) values are socialized parents in children include diligent worship, be honest, be respectful, harmonious with relatives and the community, and a way of learning achievement, and (b) how to disseminate the values in children, among others, to give advice and provide examples (exemplary). (4) The figure of a fighter in the novel Ibuk family is a family that struggles to improve the standard of living is better to work hard and cooperate with one another.