bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tree ring ecological signal is consistent with floristic composition and plant indicator values in Mediterranean Fagus sylvatica forests
Authors: Filibeck Goffredo , Adams Jonathan , Brunetti Michele , Di Filippo Alfredo , Rosati Leonardo , Scoppola Anna , Piovesan Gianluca 
Published: September 2015

Summary

We compared the multivariate patterns of tree ring chronologies with those of floristic composition (and of its associated Ellenberg indicator values – EIVs) across the whole elevation gradient of Fagus sylvatica forests in Central Italy (from 300 to 1900 m a.s.l.). Both data sets were also compared with bioclimatic parameters obtained from reconstructed, site‐representative meteorological data.

Procrustes analysis showed that the patterns of tree ring chronologies and floristic assemblages were significantly correlated. The two main bio‐climatic belts obtained from tree ring analysis showed significantly different floristic composition and significantly different distribution of EIVs.

Constrained ordination with meteorological data as covariates showed that in both data sets, most of the variation was explained by mean summer temperature, while precipitation parameters had only minor explanatory power.

Ellenberg indicator values for temperature showed a strong correlation with mean summer temperature obtained from the meteorological data. EIVs for continentality were weakly correlated with annual temperature range. No correlation emerged between the EIVs for moisture and the precipitation parameters. Constrained ordination of the tree ring data set with the floras' mean EIVs as covariates found that the most explanatory variables were the EIVs for temperature followed by the EIVs for light. This latter finding is probably a consequence of temperature control (via summer drought) on canopy Leaf Area Index.

Synthesis. Ecological classification of beech forest stands through either tree ring chronologies or floristic composition yields very similar results. Both bio‐indication methods point to the predominant role of growing‐season temperatures in controlling patterns and processes of forest ecosystems across wide elevation gradients. Thus, similarities in tree ring chronologies of the past between sites could be used to infer analogies in past floristic assemblages. Moreover, temperature indicator values obtained from floras show excellent accordance with meteorological data, allowing reliable usage of diachronic floristic data for climate change monitoring at detailed spatial scale.
Detection of mutations in JAK2 exons 12–15 by Sanger sequencing
Authors: Alghasham N. , Alnouri Y. , Abalkhail H. , Khalil S. 
Published: September 2015

SummaryIntroductionThe Janus kinase (JAK)2 p.V617F gain‐of‐function mutation is a hallmark of BCR‐ABL1‐negative myeloproliferative neoplasms (MPNs). This study analyzed JAK2 mutations in 1811 patients tested between 2010 and 2013.MethodsExons 12–15 of JAK2 were sequenced in 1706 samples, and patients harboring mutations were clinically evaluated.ResultsOf 271 patients (16%) with JAK2 mutations, 148 (54.6%) were female and 123 (45.4%) were male; 103 (38%) were local and 168 (62%) were referred; and 13 (5%) had additional genetic abnormalities. The median patient age was 54 years, and there was only one pediatric patient. In agreement with previous reports, 262 patients (96.7%) were positive for the JAK2 p.V617F mutation. Non‐p.V617F JAK2 mutations were detected in the remaining nine (3.3%) patients: five (1.8%) had a p.G571S mutation, and one (0.3%) each had p.E543_D544del, p.Y570Y silent, p.R541_E543delinsK, and p.I540_N542delinsM mutations. Diagnosis of 103 (38%) in‐house cases revealed a predominance of MPN patients (87 cases, or 84.4%).ConclusionJAK2 p.V617F was the most prevalent mutation detected among patients in this study. Non‐p.V617F JAK2 mutations were identified in exons 12 and 13 corresponding to recently reported mutations, except for the novel p.I540_N542delinsM.
Temperature Distribution in Metallic Powder Particles During Initial Stage of Field‐Activated Sintering
Authors: Trapp Johannes , Kieback Bernd 
Published: September 2015

The temperature distribution in copper and martensitic steel spheres has been investigated for the initial stage of field‐activated sintering (FAST)/spark plasma sintering (SPS) using capacitor discharges (CD) with applied voltages from one to 15 V as model experiments. At first, the evolution of the contact resistance between the spheres has been studied. The results show the reduction in the contact resistance after discharge with increasing electrical load, yet no significant dependence on the length or number of the discharge pulses. Thereby the initial resistance is only decreased distinctly if at least a certain minimal voltage was applied. Subsequently, the melting of thin coatings of different metals on copper spheres has been studied and the occurrence of molten phase and its melting point were assigned to the corresponding discharge current. Extrapolation from the currents necessary to melt the coating layers in the CD experiments to lower values typical for FAST was used to estimate the contact overtemperature in the latter case. Resulting values for copper range from 0.05 K for normal heating with 100 K/min to 5 K for maximum current output.
Draft Genome Sequences of 19 Salmonella enterica Serovar Typhimurium [4,5:i:−] Strains Resistant to Nalidixic Acid from a Long-Term Outbreak in Italy
Authors: Orsini Massimiliano , Mangone Iolanda , DiPasquale Adriano , Perticara Samuel , Sacchini Lorena , Cito Francesca , Iannetti Simona , Marcacci Maurilia , Ancora Massimo , Calistri Paolo , Di Giannatale Elisabetta , Cammà Cesare 
Published: September 2015

ABSTRACT

Here, we present the draft genome sequences of 19
Salmonella enterica
serovar Typhimurium monophasic variant [4,5:i:−] strains involved in a long-term salmonellosis outbreak that occurred in central Italy in 2013 to 2014.
Draft Genome Sequence of Kerstersia gyiorum CG1, Isolated from a Leg Ulcer
Authors: Greninger Alexander L. , Kozyreva Varvara , Truong Chau-Linda , Longoria Rose , Chaturvedi Vishnu 
Published: September 2015

ABSTRACT

We report the first draft genome sequence of
Kerstersia gyiorum
from a leg ulcer of a patient with diabetes and osteomyelitis. The 3.94-Mb genome assembly included 3,428 annotated coding sequences with an
N
50
of 223,310 bp and a plasmid encoding a type IV secretion system gene and two antitoxin genes.
Draft Genome Sequence of Type Strain Lysinibacillus xylanilyticus DSM 23493
T
Authors: Liu Guo-hong , Liu Bo , Wang Jie-ping , Che Jian-Mei , Zheng Xue-fang , Chen Qian-Qian , Ge Ci-bin 
Published: September 2015

ABSTRACT

Lysinibacillus xylanilyticus
DSM 23493
T
is a Gram-positive, spore-forming bacterium. Here, we report the 5.22-Mb genome sequence of
Lysinibacillus xylanilyticus
DSM 23493
T
, which will accelerate the application of degrading xylan and provide useful information for genomic taxonomy and phylogenomics of
Bacillus
-like bacteria.
Apgar-score in children prenatally exposed to antiepileptic drugs: a population-based cohort study
Authors: Christensen Jakob , Pedersen Henrik Søndergaard , Kjaersgaard Maiken Ina Siegismund , Parner Erik Thorlund , Vestergaard Mogens , Sørensen Merete Juul , Olsen Jørn , Bech Bodil Hammer , Pedersen Lars Henning 
Published: September 2015

ObjectivesIt is unknown if prenatal exposure to antiepileptic drugs (AEDs) increases the risk of low Apgar score in offspring.SettingPopulation-based study using health registers in Denmark.ParticipantsWe identified all 677 021 singletons born in Denmark from 1997 to 2008 and linked the Apgar score from the Medical Birth Register with information on the women's prescriptions for AEDs during pregnancy from the Danish Register of Medicinal Product Statistics. We used the Danish National Hospital Registry to identify mothers diagnosed with epilepsy before birth of the child. Results were adjusted for smoking and maternal age.ResultsAmong 2906 children exposed to AEDs, 55 (1.9%) were born with an Apgar score ≤7 as compared with 8797 (1.3%) children among 674 115 pregnancies unexposed to AEDs (adjusted relative risk (aRR)=1.41 (95% CI 1.07 to 1.85). When analyses were restricted to the 2215 children born of mothers with epilepsy, the aRR of having a low Apgar score associated with AED exposure was 1.34 (95% CI 0.90 to 2.01) When assessing individual AEDs, we found increased, unadjusted RR for exposure to carbamazepine (RR=1.86 (95% CI 1.01 to 3.42)), valproic acid (RR=1.85 (95% CI 1.04 to 3.30)) and topiramate (RR=2.97 (95% CI 1.26 to 7.01)) when compared to unexposed children.ConclusionsPrenatal exposure to AEDs was associated with increased risk of being born with a low Apgar score, but the absolute risk of a low Apgar score was <2%. Risk associated with individual AEDs indicate that the increased risk is not a class effect, but that there may be particularly high risks of a low Apgar score associated with certain AEDs.
Roberto Gomes e as tentativas de modernização do teatro brasileiro: convergências e desencontros com a dramaturgia da (in)ação de Maurice Maeterlinck
Authors: Borges Júnior Eli 
Published: September 2015

<div class="page" title="Page 2"><div class="layoutArea"><div class="column"><p><span>O artigo analisa alguns elementos fundamentais da dramaturgia simbolista de Maurice Maeterlinck e seus reflexos na obra do dramaturgo brasileiro Roberto Gomes. A partir de uma investigação breve, que se debruça principalmente sobre as características do silêncio e do esvaziamento da ação, busca-se catalisar a discussão sobre a ideia de modernização do teatro brasileiro, além de refletir sobre alguns aspectos inovadores que se desdobrariam nas novas formas artísticas da encenação contemporânea. </span></p></div></div></div>
Ensaiadores na cena brasileira dos séculos XIX e XX
Authors: Azevedo Elisabeth R. 
Published: September 2015

<div class="page" title="Page 2"><div class="layoutArea"><div class="column"><p><span>O artigo procura refletir, ainda que rapidamente, sobre a importância do estudo das atividades dos ensaiadores do teatro brasileiro do século </span><span>XIX</span><span>, procurando apresentar a trajetória de três profissionais que estiveram presentes nos palcos nacionais: Emile Doux, Enrico Cuneo e Eduardo Victorino. </span></p></div></div></div>
Prospects for Developing Subject-Oriented Education at the Senior Stage of School in the Context of Shift to the New Federal State Educational Standard
Authors: Кузнецов  , Kuznetsov A. 
Published: September 2015

The paper explores in detail the very essence of fledgling trends concerning the development of contents of the Federal State Educational Standard. It
is stated, that setting up the new Standards should be considered as the first step only. Further the next step of the Standards implementation should
follow, putting the demand to elaborate a set of regulatory documents. The principal educational program, the curriculum, the training outcomes
requirements and etc. are to be further elaborated and clarified. These particularly relate to the senior high school, where subject-oriented education is
stipulated.
›Erbauung‹ – und darüber hinaus
Authors: Köbele Susanne 
Published: September 2015

AbstractThe following paper argues for a revision of the notion of ›edification‹ in the Middle Ages. By comparing exemplary texts (including the ›Exercitia spiritualia‹, which are attributed to Gertrude the Great), it shows the ramifications, tensions and textual productivity in the medieval usage of the term ›edification‹ and in its implementation. In addition to the subsequent essay by Burkhard Hasebrink, this paper attempts to describe the different, yet similarly contradictory claims of ›edification‹ in the tension between (self)disciplining and transgression.
A DFT Study of CO and NO Adsorptions on AlN-, AlP-, and ZnO-doped Graphene Nanosheets
Authors: Promthong Niwat , Nunthaboot Nadtanet , Banchob Wanno 
Published: September 2015

Abstract
Density functional theory calculations were performed to investigate
the adsorption abilities of carbon monoxide (CO) and nitrogen
monoxide (NO) gas molecules onto pristine graphene nanosheet
(GNS), and AlN-, AlP-, and ZnO-doped GNSs. The
co-doping of AlN, AlP, and ZnO onto GNS can
improve the CO and NO adsorption abilities of GNS. The
gas adsorption abilities on the pristine and co-doped GNSs were
determined to be, in decreasing order: ZnO-GNS ∼
AlP-GNS > AlN-GNS > pristine GNSs and AlP-GNS
> AlN-GNS > ZnO-GNS > pristine GNSs for the
adsorptions of CO and NO, respectively. These newly
developed co-doped GNSs could be candidates for CO and
NO gas storages. The adsorption geometries, adsorption
energies, density of states, and charge transfers were also reported.
A Comparative Study of Two Bicyclic Ethers, Eucalyptol and 1,4-Cineole, by Broadband Rotational Spectroscopy
Authors: Medcraft Chris , Schnell Melanie 
Published: September 2015

Abstract
The rotational spectra of the two structurally related molecules,
1,4-cineole and 1,8-cineole (eucalyptol), were measured between
2–8.5 GHz with chirped pulse Fourier transform microwave
spectroscopy. The structures of these two molecules only differ in the
connectivity of an ether functional group. This results in
a significant change in the three dimensional structure of the
molecule and consequently large differences in the rotational
spectra. Only one conformer of each molecule was detected in the
molecular jet and no line splittings due to internal rotations were
detected. A substitution structure (r

s
) was determined for
eucalyptol and benchmarked to quantum chemical structures allowing for
a comparison of eucalyptol and 1,4-cineole.
Development of 23 novel polymorphic EST‐SSR markers for the endangered relict conifer Metasequoia glyptostroboides
Authors: Jin Yuqing , Bi Quanxin , Guan Wenbin , Mao Jian‐Feng 
Published: September 2015

Premise of the study:Metasequoia glyptostroboides is an endangered relict conifer species endemic to China. In this study, expressed sequence tag–simple sequence repeat (EST‐SSR) markers were developed using transcriptome mining for future genetic and functional studies.Methods and Results:We collected 97,565 unigene sequences generated by 454 pyrosequencing. A bioinformatics analysis identified 2087 unique and putative microsatellites, from which 96 novel microsatellite markers were developed. Fifty‐three of the 96 primer sets successfully amplified clear fragments of the expected sizes; 23 of those loci were polymorphic. The number of alleles per locus ranged from two to eight, with an average of three, and the observed and expected heterozygosity values ranged from 0 to 1.0 and 0.117 to 0.813, respectively.Conclusions:These microsatellite loci will enrich the genetic resources to develop functional studies and conservation strategies for this endangered relict species.
Nous/on : De la réalité linguistique à la salle de classe
Authors: Thomas Alain 
Published: September 2015

Le remplacement du pronom nous par on, fréquent en français moderne, est encore peu reconnu dans l’enseignement du FL2 au niveau universitaire canadien. Pour mieux comprendre ce retard pédagogique sur la réalité linguistique et contribuer à le réduire, nous ferons d’abord ici une synthèse des études consacrées au sujet, après un rappel historique de l’évolution des deux pronoms. Une analyse de la présentation de la première personne du pluriel dans les manuels scolaires permettra ensuite de réexaminer nos pratiques pédagogiques, non seulement pour la paire nous/on, mais aussi pour d’autres aspects du français « ordinaire », qui sont mieux acceptés dans la pratique quotidienne des locuteurs que dans le français soigné des grammairiens prescriptifs.
Easy, Green and Safe Carbonylation Reactions through Zeolite‐Catalyzed Carbon Monoxide Production from Formic Acid
Authors: Losch Pit , Felten Anne‐Sophie , Pale Patrick 
Published: September 2015

AbstractZeolites with the right shape and acid site density and strength, such as certain ZSM‐5 forms, were able to cleanly decompose formic acid to carbon monoxide (CO), and the latter could be directly used in palladium‐catalyzed carbonylation reactions. A simple two‐reactor system was designed to produce CO conveniently and then further react this gas in a safe way. The two‐reactor system is particularly cheap, easy to set up and use. In addition, the carbonylation conditions without pressure allowed for very efficient CO incorporation, with only 1% of palladium(II) chloride (PdCl2) and Xantphos.magnified image
CXCL13 and CCL11 Serum Levels and Lymphoma and Disease Activity in Primary Sjögren's Syndrome
Authors: Nocturne G. , Seror R. , Fogel O. , Belkhir R. , Boudaoud S. , Saraux A. , Larroche C. , Le Guern V. , Gottenberg J. E. , Mariette X. 
Published: September 2015

ObjectiveNon‐Hodgkin's lymphoma (NHL) is a severe complication of primary Sjögren's syndrome (SS). Ectopic germinal centers (GCs) in the salivary glands are predictors of the occurrence of NHL. Given the association between CCL11 and CXCL13 and ectopic GCs, we assessed the link between these chemokines and NHL, as well as the association between these chemokines and disease activity, in patients with primary SS.MethodsSerum levels of CCL11 and CXCL13 were evaluated by multiplex assay in 385 patients included in the Assessment of Systemic Signs and Evolution of Sjögren's Syndrome (ASSESS) cohort. The association between chemokine levels, B cell biomarkers, and patient subsets was assessed using Spearman's test for continuous data and the nonparametric Mann‐Whitney U test for categorical data. Multivariate analyses were performed to identify parameters associated with lymphoma and disease activity.ResultsSeventeen patients had a history of lymphoma, and 5 of them had developed NHL during followup. The median serum levels of CCL11 and CXCL13 in the total cohort were 106.48 pg/ml (interquartile range 69.33–149.85) and 108.31 pg/ml (interquartile range 58.88–200.13), respectively. Patients with lymphoma had higher levels of CXCL13 than did patients without lymphoma (P = 0.006) and a trend toward a higher level of CCL11 (P = 0.056). Low C4 and high BAFF levels were associated with NHL on multivariate analysis (P = 0.01 and P = 0.0002, respectively). CCL11 and CXCL13 levels correlated positively with the rheumatoid factor titer, the κ‐to‐λ free light chain ratio, and the β2‐microglubulin level. CXCL13 was the only parameter associated with disease activity on multivariate analysis.ConclusionThese findings demonstrate a link between CXCL13 and CCL11 and disease activity and lymphoma. This highlights the continuum between chronic B cell activation, disease activity, and lymphomagenesis in patients with primary SS.
Risk of Subsequent Infection Among Patients Receiving Tumor Necrosis Factor Inhibitors and Other Disease‐Modifying Antirheumatic Drugs
Authors: Accortt Neil A. , Bonafede Machaon M. , Collier David H. , Iles Jan , Curtis Jeffrey R. 
Published: September 2015

ObjectiveTo describe the incidence of subsequent serious infections in patients who received systemic drug therapy after an initial serious infection.MethodsPatients with rheumatic conditions (rheumatoid arthritis [RA], psoriatic arthritis, ankylosing spondylitis) or psoriasis who experienced a serious infection between January 1, 2006 and December 31, 2011 were identified in a claims database. Patients were required to be continuously enrolled in the Truven Health Analytics MarketScan Research Database for 12 months prior to and at least 60 days after the date of discharge or the end of intravenous antibiotic therapy for the index serious infection. Subsequent serious infection incidence rates per 100 patient‐years with 95% confidence intervals (95% CIs) were calculated for up to 18 months post‐index, starting 60 days post‐index. Cox proportional hazards models were used to adjust for baseline demographic and clinical characteristics, treatment duration, and changes during followup.ResultsAmong the 21,699 patients who met the inclusion criteria, the majority (84.3%) had RA. Patients who received tumor necrosis factor (TNF) inhibitor therapy after their index infection had a lower rate of subsequent serious infections (18.1 per 100 patient‐years for those treated with a TNF inhibitor alone and 17.3 per 100 patient‐years for those treated with a TNF inhibitor plus a nonbiologic disease‐modifying antirheumatic drug [DMARD]) compared with those treated with a nonbiologic DMARD alone (21.4 per 100 patient‐years). Etanercept, either alone (adjusted hazard ratio [HR] 0.87, 95% CI 0.77–0.99) or in combination with a nonbiologic DMARD (adjusted HR 0.76, 95% CI 0.66–0.88), and infliximab (only in combination with a nonbiologic DMARD) (adjusted HR 0.80, 95% CI 0.67–0.95) were associated with a significantly lower risk of subsequent serious infections compared with a nonbiologic DMARD alone.ConclusionWe did not observe an increased risk of subsequent infection in patients who received TNF inhibitor treatment following a serious infection. The risk of a subsequent serious infection was lower in patients treated with both a TNF inhibitor and a nonbiologic DMARD compared with that in patients treated with a nonbiologic DMARD alone.
Association of Elevations of Specific T Cell and Monocyte Subpopulations in Rheumatoid Arthritis With Subclinical Coronary Artery Atherosclerosis
Authors: Winchester Robert , Giles Jon T. , Nativ Simona , Downer Kendall , Zhang Hui‐Zhu , Bag‐Ozbek Ayse , Zartoshti Afshin , Bokhari Sabahat , Bathon Joan M. 
Published: September 2015

ObjectiveCoronary artery disease (CAD) is the leading cause of excess deaths in rheumatoid arthritis (RA). However, identification of features denoting patients with a risk of developing CAD is lacking. The composition of circulating peripheral blood mononuclear cell (PBMC) subsets in RA patients differs markedly from that in healthy controls with regard to the extent of T cell activation, with clonal expansion and differentiation to effector memory status, and presence of inflammatory monocytes. In this study, we sought to evaluate whether elevations in these PBMC subpopulations in RA patients could denote those with an increased risk of subclinical CAD, as determined by the presence of coronary artery calcification (CAC).MethodsThe study cohort comprised 72 patients with RA who underwent cardiac computed tomography to assess CAC. PBMC subsets were determined by multiparameter flow cytometry. Multivariable logistic regression was used to determine the associations between PBMC subpopulations and the presence of CAC.ResultsAmong the 72 patients with RA, 33% had CAC and exhibited significant increases in the levels of circulating CD4 T cell subsets denoting activation and differentiation to the effector memory phenotypes. Analogous increases in the levels of CD8 T cell subsets, as well as in the CD14highCD16+ intermediate monocyte subset, were also present in these patients, as compared to those without CAC. The increases in the CD4 and CD8 T cell subsets were highly intercorrelated, whereas the increases in CD14highCD16+ monocytes were independent of elevations in the CD4 T cell subsets. After adjustments for relevant confounders, the levels of CD4+CD56+CD57+ T cells and CD14highCD16+ monocytes remained associated with the presence of CAC.ConclusionThese findings indicate that PBMC subsets are markers for the presence of CAC and suggest that mechanisms of atherogenesis in RA may operate in part through the elevations in these subsets, raising further questions about the mechanisms underlying the presence of such alterations in cell composition in patients with RA and the potential for shared etiologic pathways between RA and cardiovascular disease.