bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Low-Dose Prednisolone on Hepatic and Peripheral Insulin Sensitivity, Insulin Secretion, and Abdominal Adiposity in Patients With Inflammatory Rheumatologic Disease
Authors: Petersons Carolyn J. , Mangelsdorf Brenda L. , Jenkins Arthur B. , Poljak Anne , Smith Malcolm D. , Greenfield Jerry R. , Thompson Campbell H. , Burt Morton G. 
Published: May 2013

OBJECTIVE
The metabolic effects of low-dose prednisolone and optimal management of glucocorticoid-induced diabetes are poorly characterized. The aims were to investigate the acute effects of low-dose prednisolone on carbohydrate metabolism and whether long-term low-dose prednisolone administration increases visceral adiposity, amplifying metabolic perturbations.

RESEARCH DESIGN AND METHODS
Subjects with inflammatory rheumatologic disease without diabetes mellitus were recruited. Nine subjects (age, 59 ± 11 years) not using oral glucocorticoids were studied before and after a 7- to 10-day course of oral prednisolone 6 mg daily. Baseline data were compared with 12 subjects (age, 61 ± 8 years) using continuous long-term prednisolone (6.3 ± 2.2 mg/day). Basal endogenous glucose production (EGP) was estimated by 6,6-2H2 glucose infusion, insulin sensitivity was estimated by two-step hyperinsulinemic-euglycemic clamp, insulin secretion was estimated by intravenous glucose tolerance test, and adipose tissue areas were estimated by computed tomography.

RESULTS
Prednisolone acutely increased basal EGP (2.44 ± 0.46 to 2.65 ± 0.35 mg/min/kg; P = 0.05) and reduced insulin suppression of EGP (79 ± 7 to 67 ± 14%; P = 0.03), peripheral glucose disposal (8.2 ± 2.4 to 7.0 ± 1.6 mg/kg/min; P = 0.01), and first-phase (5.9 ± 2.0 to 3.9 ± 1.6 mU/mmol; P = 0.01) and second-phase (4.6 ± 1.7 to 3.6 ± 1.4 mU/mmol; P = 0.02) insulin secretion. Long-term prednisolone users had attenuated insulin suppression of EGP (66 ± 14 vs. 79 ± 7%; P = 0.03) and nonoxidative glucose disposal (44 ± 24 vs. 62 ± 8%; P = 0.02) compared with nonglucocorticoid users, whereas basal EGP, insulin secretion, and adipose tissue areas were not significantly different.

CONCLUSIONS
Low-dose prednisolone acutely perturbs all aspects of carbohydrate metabolism. Long-term low-dose prednisolone induces hepatic insulin resistance and reduces peripheral nonoxidative glucose disposal. We conclude that hepatic and peripheral insulin sensitivity should be targeted by glucose-lowering therapy for glucocorticoid-induced diabetes.
Method simplifying calculation of coefficients of fractional parentage for translationally invariant shell-model
Authors: Mickevičius Saulius , Germanas Darius , Kalinauskas Ramutis 
Published: May 2013

Abstract
A new procedure for large-scale calculations of the coefficients of fractional parentage (CFP) for many-particle systems is presented. The approach is based on a simple enumeration scheme for antisymmetric N particle states, and we suggest an efficient method for constructing the eigenvectors of two-particle transposition operator $$P_{N_1 ,N}$$ in a subspace where N
1 and N
2 = N − N
1 nucleons basis states are already antisymmetrized. The main result of this paper is that according to permutation operators $$P_{N_1 ,N}$$ eigenvalues we can distinguish totally asymmetrical N particle states from the other states with lower degree of asymmetry.
Robust projective outer synchronization of coupled uncertain fractional-order complex networks
Authors: Wang Junwei , Zhang Yun 
Published: May 2013

AbstractIn this work, we propose a novel projective outer synchronization (POS) between unidirectionally coupled uncertain fractional-order complex networks through scalar transmitted signals. Based on the state observer theory, a control law is designed and some criteria are given in terms of linear matrix inequalities which guarantee global robust POS between such networks. Interestingly, in the POS regime, we show that different choices of scaling factor give rise to different outer synchrony, with various special cases including complete outer synchrony, anti-outer synchrony and even a state of amplitude death. Furthermore, it is demonstrated that although stability of POS is irrelevant to the inner-coupling strength, it will affect the convergence speed of POS. In particular, stronger inner synchronization can induce faster POS. The effectiveness of our method is revealed by numerical simulations on fractional-order complex networks with small-world communication topology.
Prediction and analysis of radial overcut in holes drilled by electrochemical machining process
Authors: Tajdari Mehdi , Chavoshi Saeed 
Published: May 2013

Abstract
Radial overcut predictive models using multiple regression analysis, artificial neural network and co-active neurofuzzy inference system are developed to predict the radial overcut during electrochemical drilling with vacuum extraction of electrolyte. Four process parameters, electrolyte concentration, voltage, initial machining gap and tool feed rate, are selected to develop the models. The comparison between the results of the presented models shows that the artificial neural network and co-active neuro-fuzzy inference system models can predict the radial overcut with an average relative error of nearly 5%. Main effect and interaction plots are generated to study the effects of process parameters on the radial overcut. The analysis shows that the voltage, electrolyte concentration and tool feed rate have significant effect on radial overcut, respectively, while initial machining gap has a little effect. It is also found that the increase of the voltage and electrolyte concentration increases the radial overcut and the increase of the tool feed rate decreases the radial overcut.
Femoral Deformity Planning: Intentional Placement of the Apex of Deformity
Authors: Fabricant Peter D. , Camara James M. , Rozbruch S. Robert 
Published: May 2013

Traditionally, correction of femoral deformity has been performed with osteotomies through the center of rotation of angulation (CORA), but the CORA location is not always practical. If the osteotomy is created at a site adjacent to the CORA, an additional translation must be performed to accurately correct the deformity. However, at times, the ideal osteotomy site may require an unfeasible amount of translation. Multiple osteotomies may also be problematic, and when overcorrection of the mechanical axis is planned, the CORA method is not practical.
This article describes a novel method by which the surgeon may choose the location of the osteotomy regardless of the location of the CORA and may consolidate a multiapical deformity into a single corrective osteotomy. Furthermore, intentional mechanical axis overcorrection may be performed to unload knee joint arthritis. Simple, complex, and multiapical deformities may now be corrected via a single familiar surgical procedure, such as a distal femoral osteotomy, and the need for translation is eliminated.
Intramedullary Nailing Versus Locked Plate for Treating Supracondylar Periprosthetic Femur Fractures
Authors: Horneff John G. , Scolaro John A. , Jafari S. Mehdi , Mirza Amer , Parvizi Javad , Mehta Samir 
Published: May 2013

The objective of this study was to compare retrograde intramedullary femoral nailing with supracondylar locked screw-plate fixation for the treatment of periprosthetic femur fractures following total knee arthroplasty. Time to union and full weight bearing were the primary study outcomes, with perioperative blood loss, need for transfusion, need for revision surgery, and infection being the secondary outcomes.
A retrospective review of 63 patients who sustained Rorabeck Type II periprosthetic femoral fractures was undertaken. Patients were pooled from 3 academic institutions between 2001 and 2009. Patients eligible for the study were identified from the electronic medical record using an IDX query of International Classification of Diseases 9 and Current Procedural Terminology codes for fixation of femur fracture with intramedullary implant or plate and screws. In the series, 35 patients were treated with intramedullary femoral nailing and 28 with a locked screw-plate. The 2 groups were compared for radiographic union at 6, 12, 24, and 36 weeks. At 36 weeks, radiographic union was significantly greater in the locked screw-plate group. Time to full weight bearing was not significantly different. A greater perioperative transfusion rate was observed in the locking plate group, but it also had an overall lower rate of reoperation, for any reason, compared with the intramedullary femoral nailing group. The results support the use of a laterally based locked plate in the treatment of Rorabeck type II distal femur periprosthetic fractures.
Hip Resurfacing and Conventional THA: Comparison of Acetabular Bone Stock Removal, Leg Length, and Offset
Authors: Brown Nicholas M. , Foran Jared R. H. , Della Valle Craig J. 
Published: May 2013

The purpose of this study was to compare total hip arthroplasty (THA) and hip resurfacing arthroplasty (HRA) with regard to the amount of acetabular bone stock removed and the ability to restore leg length and offset. Anteroposterior pelvis radiographs of 153 consecutive THAs and 84 consecutive HRAs were compared. Excluded patients were those with prior hip surgery, those in which a best-fit circle could not be adequately matched to the femoral head, and those with preoperative radiographic findings that precluded consideration for HRA (ie, disease severity, deformity, leg-length discrepancy).
A significant difference was found between THA and HRA with regards to age and sex but not primary diagnosis. Relative differences in acetabular bone removal were compared using a ratio of acetabular implant diameter to preoperative ipsilateral femoral head diameter measured with a best-fit circle. The ratio of acetabular cup diameter to preoperative ipsilateral femoral head diameter was significantly greater following THA than following HRA, indicating relatively more acetabular bone removal in THA procedures. Mean leg-length discrepancy was significantly greater following THA than following HRA. Offset was increased to a greater extent following THA than following HRA. Overall, HRA was associated with relatively less acetabular bone stock removal and less alteration in leg length and offset than was THA.
Propofol Inhibits Superoxide Production, Elastase Release, and Chemotaxis in Formyl Peptide–Activated Human Neutrophils by Blocking Formyl Peptide Receptor 1
Authors: Yang Shun-Chin , Chung Pei-Jen , Ho Chiu-Ming , Kuo Chan-Yen , Hung Min-Fa , Huang Yin-Ting , Chang Wen-Yi , Chang Ya-Wen , Chan Kwok-Hon , Hwang Tsong-Long 
Published: May 2013

Abstract
Neutrophils play a critical role in acute and chronic inflammatory processes, including myocardial ischemia/reperfusion injury, sepsis, and adult respiratory distress syndrome. Binding of formyl peptide receptor 1 (FPR1) by N-formyl peptides can activate neutrophils and may represent a new therapeutic target in either sterile or septic inflammation. Propofol, a widely used i.v. anesthetic, has been shown to modulate immunoinflammatory responses. However, the mechanism of propofol remains to be established. In this study, we showed that propofol significantly reduced superoxide generation, elastase release, and chemotaxis in human neutrophils activated by fMLF. Propofol did not alter superoxide generation or elastase release in a cell-free system. Neither inhibitors of γ-aminobutyric acid receptors nor an inhibitor of protein kinase A reversed the inhibitory effects of propofol. In addition, propofol showed less inhibitory effects in non-FPR1–induced cell responses. The signaling pathways downstream from FPR1, involving calcium, AKT, and ERK1/2, were also competitively inhibited by propofol. These results show that propofol selectively and competitively inhibits the FPR1-induced human neutrophil activation. Consistent with the hypothesis, propofol inhibited the binding of N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys-fluorescein, a fluorescent analog of fMLF, to FPR1 in human neutrophils, differentiated THP-1 cells, and FPR1-transfected human embryonic kidney-293 cells. To our knowledge, our results identify, for the first time, a novel anti-inflammatory mechanism of propofol by competitively blocking FPR1 in human neutrophils. Considering the importance of N-formyl peptides in inflammatory processes, our data indicate that propofol may have therapeutic potential to attenuate neutrophil-mediated inflammatory diseases by blocking FPR1.
Adam8 Limits the Development of Allergic Airway Inflammation in Mice
Authors: Knolle Martin D. , Nakajima Takahiro , Hergrueter Anja , Gupta Kushagra , Polverino Francesca , Craig Vanessa J. , Fyfe Susanne E. , Zahid Muhammad , Permaul Perdita , Cernadas Manuela , Montano Gilbert , Tesfaigzi Yohannes , Sholl Lynette , Kobzik Lester , Israel Elliot , Owen Caroline A. 
Published: May 2013

AbstractTo determine whether a disintegrin and metalloproteinase-8 (Adam8) regulates allergic airway inflammation (AAI) and airway hyperresponsiveness (AHR), we compared AAI and AHR in wild-type (WT) versus Adam8−/− mice in different genetic backgrounds sensitized and challenged with OVA or house dust mite protein extract. OVA- and house dust mite–treated Adam8−/− mice had higher lung leukocyte counts, more airway mucus metaplasia, greater lung levels of some Th2 cytokines, and higher methacholine-induced increases in central airway resistance than allergen-treated WT mice. Studies of OVA-treated Adam8 bone marrow chimeric mice confirmed that leukocyte-derived Adam8 predominantly mediated Adam8’s anti-inflammatory activities in murine airways. Airway eosinophils and macrophages both expressed Adam8 in WT mice with AAI. Adam8 limited AAI and AHR in mice by reducing leukocyte survival because: 1) Adam8−/− mice with AAI had fewer apoptotic eosinophils and macrophages in their airways than WT mice with AAI; and 2) Adam8−/− macrophages and eosinophils had reduced rates of apoptosis compared with WT leukocytes when the intrinsic (but not the extrinsic) apoptosis pathway was triggered in the cells in vitro. ADAM8 was robustly expressed by airway granulocytes in lung sections from human asthma patients, but, surprisingly, airway macrophages had less ADAM8 staining than airway eosinophils. Thus, ADAM8 has anti-inflammatory activities during AAI in mice by activating the intrinsic apoptosis pathway in myeloid leukocytes. Strategies that increase ADAM8 levels in myeloid leukocytes may have therapeutic efficacy in asthma.
Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1
Authors: Yamazaki Chihiro , Sugiyama Masanaka , Ohta Tomokazu , Hemmi Hiroaki , Hamada Eri , Sasaki Izumi , Fukuda Yuri , Yano Takahiro , Nobuoka Mikako , Hirashima Takeshi , Iizuka Akihiko , Sato Katsuaki , Tanaka Takashi , Hoshino Katsuaki , Kaisho Tsuneyasu 
Published: May 2013

Abstract
Dendritic cells (DCs) consist of various subsets that play crucial roles in linking innate and adaptive immunity. In the murine spleen, CD8α+ DCs exhibit a propensity to ingest dying/dead cells, produce proinflammatory cytokines, and cross-present Ags to generate CD8+ T cell responses. To track and ablate CD8α+ DCs in vivo, we generated XCR1-venus and XCR1-DTRvenus mice, in which genes for a fluorescent protein, venus, and a fusion protein consisting of diphtheria toxin receptor and venus were knocked into the gene locus of a chemokine receptor, XCR1, which is highly expressed in CD8α+ DCs. In both mice, venus+ cells were detected in the majority of CD8α+ DCs, but they were not detected in any other cells, including splenic macrophages. Venus+CD8α+ DCs were superior to venus−CD8α+ DCs with regard to their cytokine-producing ability in response to TLR stimuli. In other tissues, venus+ cells were found primarily in lymph node (LN)-resident CD8α+, LN migratory and peripheral CD103+ DCs, which are closely related to splenic CD8α+ DCs, although some thymic CD8α−CD11b− and LN CD103−CD11b− DCs were also venus+. In response to dsRNAs, diphtheria toxin–treated XCR1-DTR mice showed impaired CD8+ T cell responses, with retained cytokine and augmented CD4+ T cell responses. Furthermore, Listeria monocytogenes infection and anti–L. monocytogenes CD8+ T cell responses were defective in diphtheria toxin–treated XCR1-DTRvenus mice. Thus, XCR1-expressing DCs were required for dsRNA- or bacteria-induced CD8+ T cell responses. XCR1-venus and XCR1-DTRvenus mice should be useful for elucidating the functions and behavior of XCR1-expressing DCs, including CD8α+ and CD103+ DCs, in lymphoid and peripheral tissues.
Th1/Th17-Mediated Interstitial Pneumonia in Chronic Colitis Mice Independent of Intestinal Microbiota
Authors: Nemoto Yasuhiro , Kanai Takanori , Takahara Masahiro , Oshima Shigeru , Okamoto Ryuichi , Tsuchiya Kiichiro , Matsumoto Satoshi , Watanabe Mamoru 
Published: May 2013

Abstract
Although intestinal microbiota are essential for the development of T cell–mediated colitis, it remains undetermined whether they enhance or suppress the chronic extraintestinal inflammation that often complicates inflammatory bowel diseases. In this study, we investigate the role of intestinal microbiota in the development of colitis and extraintestinal manifestations in a mouse model in which colitis was induced in SCID mice by adoptive transfer of CD4+CD45RBhigh T cells. Under specific pathogen-free conditions, these mice developed both colitis and extraintestinal interstitial pneumonia, whereas mice given a mixture of antibiotics did not develop colitis, but, surprisingly, developed Th1/Th17-mediated IP. Irrespective of antibiotic treatment, cotransfer of CD4+CD25+ regulatory T cells suppressed the development of pneumonitis and colitis, with all local CD4+CD45RBhigh T cell–derived cells converted to CD44highCD62L−IL-7Rαhigh effector–memory T cells. Retransfer of CD4+ effector–memory T cells from the lungs of antibiotic-treated mice with IP not only induced IP in both antibiotic-treated and -untreated recipients but also induced colitis in the untreated recipients. In summary, we have established a unique model of Th1/Th17-mediated IP in microbiota-free and antibiotic-treated mice. This model may be valuable in investigating the immunological mechanisms underlying extraintestinal disorders in patients with inflammatory bowel disease.
Age-Associated Changes in the Differentiation Potentials of Human Circulating Hematopoietic Progenitors to T- or NK-Lineage Cells
Authors: Kyoizumi Seishi , Kubo Yoshiko , Kajimura Junko , Yoshida Kengo , Imai Kazue , Hayashi Tomonori , Nakachi Kei , Young Lauren F. , Moore Malcolm A. , van den Brink Marcel R. M. , Kusunoki Yoichiro 
Published: May 2013

Abstract
Age-associated changes of T and NK cell (T/NK) potential of human hematopoietic stem cells are unknown. In this study, we enumerate and characterize T/NK precursors among CD34+Lin− cell populations circulating in normal human adult peripheral blood (PB) by a limiting-dilution assay using coculture with OP9-DL1 stroma cells expressing Notch 1 ligand, Delta–like 1. The frequency of T cell precursors in CD34+Lin− cells was found to decrease with donor age, whereas the ratio of NK to T cell precursor frequency (NK/T ratio) increased with age, suggesting that lymphoid differentiation potential of PB progenitors shifts from T to NK cell lineage with aging. Clonal analyses of CD34+Lin− cells showed that differences in the NK/T ratio were attributable to different distributions of single- and dual-lineage T/NK precursor clones. Because nearly all of the clones retained monocyte and/or granulocyte differentiation potentials in coculture with OP9-DL1 cells, T/NK precursors in PB are considered to be contained in the pool of T/NK/myeloid multipotent progenitors. The age-associated increase in NK over T cell commitment might occur in precursor cells with T/NK/myeloid potential.
An Essential Role of Antibodies in the Control of Chikungunya Virus Infection
Authors: Lum Fok-Moon , Teo Teck-Hui , Lee Wendy W. L. , Kam Yiu-Wing , Rénia Laurent , Ng Lisa F. P. 
Published: May 2013

Abstract
In recent years, Chikungunya virus (CHIKV) was responsible for epidemic outbreaks in intertropical regions. Although acquired immunity has been shown to be crucial during CHIKV infection in both humans and mice, their exact role in the control of CHIKV infection remains unclear. In this study, wild-type (WT), CD4−/−, and B cell (μMT) knockout mice were infected with CHIKV. Sera were taken at different days postinfection and measured for anti-CHIKV Ab levels. Isotype and neutralizing capacity of these Abs were assessed in vitro, and specific linear epitopes were mapped. Viremia in CHIKV-infected μMT mice persisted for more than a year, indicating a direct role for B cells in mediating CHIKV clearance. These animals exhibited a more severe disease than WT mice during the acute phase. Characterization of CHIKV-specific Abs revealed that anti-CHIKV Abs were elicited early and targeted epitopes mainly at the C terminus of the virus E2 glycoprotein. Furthermore, CD4−/− mice could still control CHIKV infection despite having lower anti-CHIKV Ab levels with reduced neutralizing capacity. Lastly, pre-existing natural Abs in the sera of normal WT mice recognized CHIKV and were able to partially inhibit CHIKV. Taken together, natural and CHIKV infection–induced specific Abs are essential for controlling CHIKV infections.
Galois Representations Over Fields of Moduli and Rational Points on Shimura Curves
Authors: Rotger Victor , de Vera-Piquero Carlos 
Published: May 2013

AbstractThe purpose of this note is to introduce a method for proving the non-existence of rational
points on a coarse moduli space X of abelian varieties over a given number field K in cases where the moduli problem is not fine and points in X(K) may not be represented by an abelian variety (with additional structure) admitting a model over the field K. This is typically the case when the abelian varieties that are being classified have even dimension. The main idea, inspired by the work of Ellenberg and Skinner on the modularity of ℚ-curves, is that one may still attach a Galois representation of Gal(/K) with values in the quotient group GL(Tℓ(A))/ Aut(A) to a point P = [A] ∈ X(K) represented by an abelian variety A/, provided Aut(A) lies in the centre of GL(Tℓ(A)). We exemplify our method in the cases where X is a Shimura curve over an imaginary quadratic field or an Atkin–Lehner quotient over ℚ.
Babil glossolalique et voyage aux limites des mots
Authors: Beaude Pierre-Marie 
Published: May 2013

Dans cette étude, l’auteur analyse deux manières très opposées de se servir des mots : la glossolalie et la prophétie-anathème d’une part, et l’expérience de langage rapportée par l’apôtre Paul en 2 Co 12.
L’arrière-fond néopythagoricien de la chute (σφάλμα/νεῦσις) de l’Âme dans la gnose et son écho dans les traités 33 et 34 de Plotin
Authors: Narbonne Jean-Marc 
Published: May 2013

Pour parler de la chute ou de la déclinaison de l’Âme (Sophia) dans le cadre des récits cosmogoniques gnostiques, Plotin a recours, en sus du terme νεῦσις, au substantif σφάλμα (ou encore au verbe correspondant σφάλλεσθαι), comme s’il s’agissait d’un synonyme de νεῦσις. L’enquête que nous avons menée montre le bien-fondé de cet usage, puisque le terme σφάλμα est, de fait, utilisé par les hérésiologues pour décrire, dans un langage hérité du néo-pythagorisme et donc rythmé par le nombre, la chute de Sophia, laquelle incarne le douzième éon de la Dodécade en même temps que le trentième et dernier éon de l’ensemble du Plérôme. Rapporté à la métaphysique pythagoricienne dont il relève, le récit gnostique perd toute apparence d’arbitraire et révèle enfin sa véritable structure, commandée de bout en bout par le nombre. Il est raisonnable de penser que l’arithmologie rivale du traité 34 de Plotin est là pour y couper court.