bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of management innovativeness in modern organizations
Authors: Nedelko Zlatko , Potocan Vojko 
Published: March 2013

PurposeThe main purpose of this paper is to emphasize the role and importance of management innovativeness for development of innovative working and behavior of organization and its employees.Design/methodology/approachGeneral management literature quotes a plethora of reasons for the differences in organizations development level. Many theorists and practicians have unified opinion that the differences between low and high developed organizations are also due to the low innovativeness, i.e. the level of innovative working and behavior of all employees. This paper is based on the foundation that management attitudes towards innovativeness are crucial for increasing innovativeness in organization.FindingsIncreasing the level of innovativeness in an organization is importantly dependent upon appropriate working and behavior of management, which must create and maintain appropriate conditions for innovative working and behavior of organization as a whole and its employees. This contribution confirms that management readiness for innovating has a central role in organizations' shift from low to high innovative organizations.Originality/valueThe paper provides a comprehensive approach for considering the role of management innovativeness in low and high innovative organizations. Typical drivers of management innovativeness are outlined in framework of low and high innovative organizations. A framework for future empirical investigation is proposed.
Post‐crisis bank liquidity risk management disclosure
Authors: Asongu Simplice A. 
Published: March 2013

PurposeThe purpose of this paper is to investigate post‐crisis measures banks have adopted in a bid to manage liquidity risk. It is based on the fact that the financial liquidity market was greatly affected during the recent economic turmoil and financial meltdown. During the crisis, liquidity risk management disclosure was crucial for confidence building in market participants.Design/methodology/approachThe study investigates if Basel II pillar 3 disclosures on liquidity risk management are applied by 20 of top 33 world banks. Bank selection is based on information availability, geographic balance and comprehensiveness of the language in which information is provided. This information is searched from the World Wide Web, with a minimum of one hour allocated to “content search”, and indefinite time for “content analyses”. Such content scrutiny is guided by 16 disclosure principles classified in four main categories.FindingsOnly 25 per cent of sampled banks provide publicly accessible liquidity risk management information, a clear indication that in the post‐crisis era, many top ranking banks still do not take Basel disclosure norms seriously, especially the February 2008 pre‐crisis warning by the Basel Committee on Banking Supervision.Research limitations/implicationsBank stakeholders should easily have access to information on liquidity risk management. Banks falling‐short of making such information available might not inspire confidence in market participants in events of financial panic and turmoil. As in the run‐up to the previous financial crisis, if banks are not compelled to explicitly and expressly disclose what measures they adopt in a bid to guarantee stakeholder liquidity, the onset of any financial shake‐up would only precipitate a meltdown. The main limitation of this study is the use of the World Wide Web as the only source of information available to bank stakeholders and/or market participants.Originality/valueThe contribution of this paper to literature can be viewed from the role it plays in investigating post‐crisis measures banks have adopted in a bid to inform stakeholders on their management of liquidity risk.
Determinants of demand on family Takaful in Malaysia
Authors: Sherif Mohamed , Azlina Shaairi Nor 
Published: March 2013

PurposeThe purpose of this paper is to identify the driving forces that influence family Takaful demand in Malaysia. The paper examines various identified and available economics and socio‐demographic variables.Design/methodology/approachUsing ordinary least square (OLS) and generalised method of moments (GMM) techniques, the paper investigates the significance of the identified economic and socio‐demographic factors in determining the consumption of family Takaful. The paper first examines a full model that combines all variables; second, a model that controls for product market factors; and finally, a model that controls for socio‐demographic factors. Following Anderson and Nevin, Haberman, Lenten and Rulli and Josa the paper further separates all models into linear and log‐linear demand functions.FindingsThe paper demonstrates that income, Islamic banking development, education, dependency ratio and Muslim population factors are positively related to Takaful demand. On the other hand, inflation, real interest rate, financial development and life expectancy appear to be the significant factors that adversely influence the total family Takaful consumption.Research limitations/implicationsThe major limitation of this paper is the small sample size. Therefore, future studies may expand the variables omitted in this study due to unavailability of data, which may be influential in explaining the family Takaful demand in Malaysia. Possible influential variables may include government social security expenditure, price of Takaful and level of competition within the Takaful and insurance industry. Research should also be conducted on the impact of the legal system and government policies on the demand for family Takaful in the country. Finally, the study focuses solely on the determinants of demand for family Takaful. Nevertheless, the supply‐side of the equation should not be neglected and should be incorporated in future studies.Originality/valueIt is obvious that there are very few studies that focus on the Malaysian market and indeed, none of them gives attention to the factors that influence demand for family Takaful. In this regard, this study contributes in filling the gaps in the scope and coverage of studies in similar area. While this study is expected to provide more understanding and awareness on the concept of Takaful and the factors that influence its demand, the authors hope that it would encourage more studies on various issues on the Takaful industry so as to help researchers to understand more aspects of this new emerging business.
Influencing factors on carbon reporting: an empirical study in Spanish companies
Authors: María González‐González José , Zamora‐Ramírez Constancio 
Published: March 2013

PurposeThe Carbon Disclosure Project (CDP) has become an international instrument for carbon reporting of companies. The purpose of this paper is to analyze the influence of some factors of the institutional environment of organizations (regulatory pressure, sustainability normative demands and interconnectedness) on the evaluation obtained by Spanish companies in this project.Design/methodology/approachThis paper has proceeded to make a multiple regression analysis in order to analyze the relationship between the dependent variable (“Carbon Disclosure” qualification) and independent variables (regulatory pressure, sustainability normative demands and interconnectedness) supported on the computer programStatistical Package for the Social Sciences(SPSS).FindingsThe results show that the interconnectedness of companies through their participation in associations that fight against climate change is the analyzed factor with a higher predictive power and statistical significance. Also, the regulatory pressure and normative demands from sustainability indexes, such as Dow Jones Sustainability Index, influence the carbon reporting of organizations participating in the CDP.Research limitations/implicationsThe main limitation of this paper is the reduced number of Spanish companies participating in the CDP.Originality/valueThis paper highlights the importance of the role developed by the associations fighting against climate change, since they allow the members to belong to a network through which they share resources, norms and values that positively and significantly influence their behaviour related to carbon reporting.
Pharmacokinetic–Pharmacodynamic Modelling of Biomarker Response to Sitagliptin in Healthy Volunteers
Authors: Kim Bo‐Hyung , Kim Sung Eun , Kang Dongwoo , Lim Kyoung Soo , Kim Jung‐Ryul , Jang In‐Jin , Shin Sang‐Goo , Yoon Seo Hyun , Cho Joo‐Youn , Yu Kyung‐Sang 
Published: March 2013

AbstractPharmacokinetic/pharmacodynamic (PK/PD) models can be useful tools in new drug development and also optimal drug therapy in patients. This study was designed to develop a PK/PD model of sitagliptin based on the physiology of incretin. The PK/PD data included information derived from two different studies. Study 1 was conducted as a one‐sequence, three‐period, repeated‐dose, dose escalation (sitagliptin 25, 50 and 100 mg q.d.) design in twelve healthy volunteers. Study 2 was a first‐in‐man study for the newly developed dipeptidyl peptidase‐4 (DPP‐4) inhibitor in healthy volunteers. In study 1, blood samples were collected to measure sitagliptin concentrations, DPP‐4 activity and active glucagon‐like peptide‐1 (GLP‐1) concentrations. In study 2, only data from the ‘placebo group’ were used, and blood samples were collected to measure DPP‐4 activity, active GLP‐1 concentrations and glucose concentrations. A PK/PD analysis was conducted using a non‐linear mixed effects modelling approach. Sitagliptin pharmacokinetics was modelled using a two‐compartment model with first‐order absorption. Changes in DPP‐4 inhibition were linked to the PK model using a sigmoid Emax model, whereas the active GLP‐1 changes were explained using an indirect response model; this model incorporated the glucose and DPP‐4 inhibition models. The PK/PD model developed adequately described the changes in sitagliptin concentration, DPP‐4 inhibition and active GLP‐1 concentration in healthy volunteers.
Population‐based comparison of laparoscopic and open pyeloplasty in paediatric pelvi‐ureretic junction obstruction
Authors: Knoedler John , Han Leona , Granberg Candace , Kramer Stephen , Chow George , Gettman Matthew , Kimball Brittany , Moriarty James , Kim Simon , Husmann Douglas 
Published: March 2013

Objective
To describe the extent of use and in‐hospital outcomes of open and laparoscopic pyeloplasty for paediatric pelvi‐ureteric junction (PUJ) obstruction in the USA.
Patients and Methods
Using the 2004–2008 Nationwide Inpatient Sample, we identified 4590 paediatric patients (≤18 years old) who underwent open or laparoscopic pyeloplasty for PUJ obstruction at 195 hospitals.
Multivariable regression models were used to test the associations between hospital and patient covariates (age, gender, race, primary health insurance), type of admission (emergent vs elective), and hospital characteristics (teaching vs non‐teaching status; rural vs urban location) with complications, length of stay (LOS), and total hospitalization costs.
Results
During the 5‐year study interval, 4426 (96.4%) and 164 (3.6%) paediatric patients diagnosed with PUJ obstruction underwent open and laparoscopic pyeloplasty, respectively.
The proportion of patients undergoing laparoscopic pyeloplasty gradually increased from 2.4% in 2004 to 4.4% in 2008, but this increase was not significant (P = 0.22 for trend).
On multivariable analysis, laparoscopic pyeloplasty was observed to have rates of postoperative complications (2.51 vs 5.00; P = 0.67), LOS (2.42 vs 2.75; P = 0.33) and total hospitalization cost ($9755 vs $8537; P = 0.24) similar to those of open pyeloplasty.
Conclusions
While laparoscopic pyeloplasty was generally an infrequent operation performed for paediatric PUJ obstruction during the period studied, this minimally invasive surgery provided similar outcomes in terms of in‐hospital complications, LOS and total hospitalization costs.
The results of this study inform policymakers about the comparative effectiveness of laparoscopic and open pyeloplasty.
Deep UV autofluorescence microscopy for cell biology and tissue histology
Authors: Jamme Frédéric , Kascakova Slavka , Villette Sandrine , Allouche Fatma , Pallu Stéphane , Rouam Valérie , Réfrégiers Matthieu 
Published: March 2013

Background InformationAutofluorescence spectroscopy is a powerful tool for molecular histology and for following metabolic processes in biological samples as it does not require labelling. However, at the microscopic scale, it is mostly limited to visible and near infrared excitation of the samples. Several interesting and naturally occurring fluorophores can be excited in the UV and deep UV (DUV), but cannot be monitored in cellulo nor in vivo due to a lack of available microscopic instruments working in this wavelength range.To fulfil this need, we have developed a synchrotron‐coupled DUV microspectrofluorimeter which is operational since 2010. An extended selection of endogenous autofluorescent probes that can be excited in DUV, including their spectral characteristics, is presented. The distribution of the probes in various biological samples, including cultured cells, soft tissues, bone sections and maize stems, is shown to illustrate the possibilities offered by this system.In this work we demonstrate that DUV autofluorescence is a powerful tool for tissue histology and cell biology.ResultsTo fulfil this need, we have developed a synchrotron‐coupled DUV microspectrofluorimeter which is operational since 2010. An extended selection of endogenous autofluorescent probes that can be excited in DUV, including their spectral characteristics, is presented. The distribution of the probes in various biological samples, including cultured cells, soft tissues, bone sections and maize stems, is shown to illustrate the possibilities offered by this system.In this work we demonstrate that DUV autofluorescence is a powerful tool for tissue histology and cell biology.ConclusionsIn this work we demonstrate that DUV autofluorescence is a powerful tool for tissue histology and cell biology.
Targeting survival pathways in chronic myeloid leukaemia stem cells
Authors: Sinclair A , Latif A L , Holyoake T L 
Published: March 2013

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder characterized by the presence of a fusion oncogene BCR‐ABL, which encodes a protein with constitutive TK activity. The implementation of tyrosine kinase inhibitors (TKIs) marked a major advance in CML therapy; however, there are problems with current treatment. For example, relapse occurs when these drugs are discontinued in the majority of patients who have achieved a complete molecular response on TKI and these agents are less effective in patients with mutations in the BCR‐ABL kinase domain. Importantly, TKI can effectively target proliferating mature cells, but do not eradicate quiescent leukaemic stem cells (LSCs), therefore allowing disease persistence despite treatment. It is essential that alternative strategies are used to target the LSC population. BCR‐ABL activation is responsible for the modulation of different signalling pathways, which allows the LSC fraction to evade cell death. Several pathways have been shown to be modulated by BCR‐ABL, including PI3K/AKT/mTOR, JAK‐STAT and autophagy signalling pathways. Targeting components of these survival pathways, alone or in combination with TKI, therefore represents an attractive potential therapeutic approach for targeting the LSC. However, many pathways are also active in normal stem cells. Therefore, potential targets must be validated to effectively eradicate CML stem cells while sparing normal counterparts. This review summarizes the main pathways modulated in CML stem cells, the recent developments and the use of novel drugs to target components in these pathways which may be used to target the LSC population.Linked ArticlesThis article is part of a themed section on Emerging Therapeutic Aspects in Oncology. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2013.169.issue‐8
Cultural differences in the development of processing speed
Authors: Kail Robert V. , McBride‐Chang Catherine , Ferrer Emilio , Cho Jeung‐Ryeul , Shu Hua 
Published: March 2013

AbstractThe aim of the present work was to examine cultural differences in the development of speed of information processing. Four samples of US children (N = 509) and four samples of East Asian children (N = 661) completed psychometric measures of processing speed on two occasions. Analyses of the longitudinal data indicated that, although processing speed was comparable among US and East Asian children at the youngest age (~4.5 years), it developed more rapidly in some but not all of the East Asian samples. Results are discussed in terms of factors that may promote more rapid development of processing speed in some East Asian cultures.
Competitiveness by Design: An Institutionalist Perspective on the Resurgence of a “Mature” Industry in a High‐Wage Economy
Authors: Hatch Carolyn J. 
Published: March 2013

AbstractIn the midst of the widespread, long‐term economic downturn throughout theCanadian manufacturing landscape, the contract (or office) furniture sector has demonstrated resilience and vibrancy. The study reported here investigated the institutional foundations of innovation and competitive advantage in this dynamic, design‐led, export‐oriented manufacturing sector. It connects to ongoing work in economic geography and the social sciences to enhance economic geographers' understanding of the role of institutions in shaping the practices of firms and competitive outcomes and seeks to advance a more agency‐centered institutionalist economic geography. The study focused on three dimensions of industrial practices: (1) the use of training and investments in technology, (2) the nature of employment relations, and (3) the use of design. The analysis reveals that the most globally competitive firms operating in aCanadian institutional context prosper by learning a set of production practices and the value of design‐intensive products from the embodied knowledge of their founders, who have lived, studied and worked in high‐wage, coordinated market economies of continentalEurope. The ability of these entrepreneurs to transfer industrial knowledge from continentalEurope toCanada has had direct benefits for learning and innovation processes that are critical to the synthetic knowledge base of this sector. The empirical analysis entails a sector wide survey questionnaire (N = 220) as well as 55 in‐depth interviews with senior managers, production workers, and designers from a subset of leading firms.
Energy reserves of parasitoids depend on honeydew from non‐hosts
Authors: TENA ALEJANDRO , PEKAS APOSTOLOS , WÄCKERS FELIX L. , URBANEJA ALBERTO 
Published: March 2013

Abstract
Adult parasitoids depend on sugar‐rich foods such as nectar and honeydew to meet their energy requirements and control insect pests. However, it is poorly known whether parasitoids can detect and feed on honeydew in agroecosystems, where it is the primary carbohydrate source, because this sugar source is less apparent in comparison to nectar and sometimes contains repellent compounds for parasitoids.
High‐performance liquid chromatography (HPLC) analyses were carried out to test whether Aphytis melinus DeBach (Hymenoptera: Aphelinidae), a parasitoid whose host does not produce honeydew, feeds on honeydew from non‐hosts. In addition, the correlation between the parasitoid's sugar reserves and honeydew abundance was determined. To do this, both the levels of honeydew producers and the sugar levels of individual collected parasitoids were assessed during different seasons. The overall sugar content was treated as an indicator of energy reserves and the erlose–melezitose ratio as an indicator of honeydew feeding.
The data show that A. melinus fed commonly on honeydew from non‐host hemipterans. More than 50% of the female parasitoids collected in spring and summer had recently fed on honeydew and most of them showed a high sugar content.
However, in autumn, when the number of honeydew producers was three times lower than in spring and summer, less than 20% of A. melinus were found to have fed on honeydew, with the average total sugar content being reduced by a factor of three.
This study demonstrates that A. melinus commonly feeds on honeydew in the field, even though its host does not produce honeydew. The results also suggest that the exploitation of honeydew by A. melinus is a function of the density and species of honeydew producers.
Mapping complex soil patterns with multiple‐point geostatistics
Authors: Meerschman E. , Van Meirvenne M. , Van De Vijver E. , De Smedt P. , Islam M. M. , Saey T. 
Published: March 2013

SummaryThe commonly used variogram function is incapable of modelling complex spatial patterns associated with repetitive, connected or curvilinear features, because it is a two‐point statistic. Because this was strongly limiting to petroleum‐ and hydrogeologists, they developed multiple‐point geostatistics (MPG), an approach that replaces the variogram by a training image (TI). However, soil scientists also face complex spatial patterns andMPGmight be of use to them as well. Therefore, this paper aims to introduceMPGto soil science and demonstrate its potential with a case study of polygonal subsoil patterns caused byWeichselian periglacial frost cracks inBelgium. A high‐resolution proximal soil sensing survey provided a reference image from which a continuous (655 sensor data) and a categorical (100 point observations) dataset were extracted. As a continuousTI, we used the geophysical data of another part of the field, and as categoricalTIwe used a classified photograph of an ice‐wedge network inAlaska. The resultingMPGmaps reconstructed the polygonal patterns very well and corresponded closely to the reference image. Consequently, we identifyMPGas a promising technique to map complex soil patterns and suggest that it should be added to the pedometrician's toolbox.
Expansion of epidermal progenitors with high p63 phosphorylation during wound healing of mouse epidermis
Authors: Suzuki Daisuke , Senoo Makoto 
Published: March 2013

AbstractThe transcription factor p63 plays an essential role in maintaining the proliferative potential of epidermal stem cells. We have shown recently that under homoeostatic conditions, phosphorylation of p63 increases during the early transition of stem cells to transit‐amplifying cells in human epidermis. However, how p63 phosphorylation relates to the regenerative processes during wound healing remains unknown. In this study, we characterize epidermal cells that contribute to wound repair in mouse models using phosphorylated p63 as a marker for stem cell differentiation. Our studies reveal that epidermal progenitors with high p63 phosphorylation preferentially expand in response to wounding in both full‐thickness wound and surface injury models. As phosphorylated p63 levels inversely correlate with the proliferative potential of epidermal progenitors, p63 phosphorylation may serve as a therapeutic target to modulate the function of these regenerative cells during wound healing.