bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posterior Cruciate Ligament Reconstruction Using Single-Bundle Achilles Allograft with Open Tibial Inlay Fixation
Authors: Zehir Sinan , Elmalı Nurzat , Çalbıyık Murat , Taşdemir Zeki , Sağlam Fevzi 
Published: December 2014

Objectives: PCL reconstruction research has shown that the tibial inlay and transtibial tunnel procedures offer similar biomechanical results. The purpose of this study was to evaluate the early results of PCL reconstruction using a single-bundle Achilles allograft and tibial inlay fixation. Methods: We retrospectively studied 14 patients who had undergone PCL reconstruction using the direct tibial inlay fixation technique from 2009 to 2013, with a mean follow-up of 13.4 months. (6-28 months). The patients were 11males and 3 females with an average age of 29.2 years (17-41 years). Ipsilateral femoral shaft fractures were determined in 2 cases, ipsilateral trochanteric fracture in 1 case and popliteal artery injury in 1 case. Surgery was performed within 2-4 weeks. Spanning-joint external fixation was applied to 2 patients because of gross instability with failure to maintain reduction in a brace. Combined reconstructions involving the posterolateral corner (9/14), anterior cruciate ligament (ACL (11/14)), or medial collateral ligament (MCL (1/14)) were performed. All PCL reconstructions were performed with Achilles allograft. In 1 case with arterial injury, the repair was made by a cardiovascular surgeon. In 2 case, deep infection developed, which was controlled with debridement and antibiotic treatment. Superficial peroneal nerve injury in 1 case was treated with tenolysis in the 6th month, then partial healing was seen at 18 months. In all patients, the preoperative posterior drawer (PD) examination was positive. All patients were evaluated with preoperative and postoperative examination and x-rays. The International Knee Documentation Committee (IKDC) evaluation was applied to all patients at the final follow-up. Results: Postoperative PD examination demonstrated the following: 0 (normal) in 4 patients, 1+ in 7 patients, and 2+ in 3 patients, compared to the preoperative PD of 3+ or greater in all patients. Preoperative IKDC objective evaluation rated all knees as severely abnormal based on instability. The final follow-up objective IKDC evaluation distribution was as follows: A, 4 knees; B, 6 knees; C, 3 knees and D, 1 knee, compared to D in all 14 knees preoperatively. The average final follow-up IKDC subjective score was 74.1 (20-100). Conclusion: Despite transtibial PCL reconstruction being advocated by several authors, it has technical difficulties of the arthroscopic approach to the posterior compartment of the knee. In the open inlay technique, posterior arthrotomy allows accurate placement of the tibial PCL insertion, avoiding the killer curve and more closely duplicating the normal PCL anatomy. Based on our initial experience with this technique at early follow-up, we continue to use the tibial inlay technique as our preferred technique for isolated or combined reconstruction of the PCL.
Comparing Effectiveness Between a Power-Drill-Mounted Device and Conventional Free-Handed Technique for Distal Locking of Intramedullary Implants
Authors: Wattanakitkrileart Supachoke , Tangtrakulwanich Boonsin , Yuenyongviwat Varah 
Published: December 2014

Objectives: The procedure for distal locking of intramedullary nails (IM nail) is one of the time-consuming procedures and also exposes the surgical team and patient to high levels of radiation. Many techniques and devices have been created to solve the problems. Nonetheless, conventional free-hand technique is still the most popular due to easy-to-use and no added device needed. This research aims to study the accuracy of a drill-mounted device with free-handed technique in the distal locking of IM nail procedure. Methods: This is an experimental study. The device was made from PVC pipes. In this study, IM-nail-inserted synthetic femoral bones (Synbone®) were set as in IM nail procedure. Four orthopedic surgeons were instructed and performed the distal locking procedure with free-handed technique and then with the device (totally 20 times for each technique). The radiation exposure time and operating time were recorded. Results: The drill-mounted device reduced the radiation exposure time statistically significant lower than the free-handed technique. However, there was no different in operative time between the two techniques. Screw misdirection occurred two times in free-handed technique but not found in our device-assisted group. Conclusion: In this experiment, the new-designed device can reduce the radiation exposure time in distal IM nail interlocking procedure. Nonetheless, further clinical study is required to confirm our results.
The role of galectin-3 and galectin-3–binding protein in venous thrombosis
Authors: DeRoo Elise P. , Wrobleski Shirley K. , Shea Evelyn M. , Al-Khalil Ramsey K. , Hawley Angela E. , Henke Peter K. , Myers Daniel D. , Wakefield Thomas W. , Diaz Jose A. 
Published: November 2014

Key PointsWe determined the location of gal3bp and gal3 and their role in promoting VT and leukocyte/endothelial cell interactions for the first time. Gal3bp and gal3 have the potential to be used as targets for future VT therapies.
Toward optimal therapy for inhibitors in hemophilia
Authors: Kempton Christine L. , Meeks Shannon L. 
Published: November 2014

Abstract
Treatment of patients with hemophilia A and B has undergone significant advances during the past 2 decades. However, despite these advances, the development of antibodies that inhibit the function of infused clotting factor remains a major challenge and is considered the most significant complication of hemophilia treatment. This chapter reviews current tools available for the care of patients with inhibitors and highlights areas where progress is imminent or strongly needed. For management of bleeding, bypassing agents remain the mainstay of therapy. Recombinant factor VIIa and activated prothrombin complex concentrates are similarly effective in populations of patients with hemophilia and inhibitors; however, individuals may show a better response to one agent over another. Recent studies have shown that prophylaxis with bypassing agents can reduce bleeding episodes by ∼50%-80%. The prophylactic use of bypassing agents is an important tool to reduce morbidity in patients before they undergo immune tolerance induction (ITI) and in those with persistent high titer inhibitors, but cost and lack of convenience remain barriers. Because of the significant burden that inhibitors add to the individual patient and the health care system, inhibitor eradication should be pursued in as many patients as possible. ITI is an effective tool, particularly in patients with severe hemophilia A and good risk profiles, and leads to a return to a normal factor VIII response in ∼60% of patients. However, for the group of patients who fail to respond to ITI or have hemophilia B, new and improved tools are needed.
Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations
Authors: Pawlyn Charlotte , Melchor Lorenzo , Murison Alex , Wardell Christopher P. , Brioli Annamaria , Boyle Eileen M. , Kaiser Martin F. , Walker Brian A. , Begum Dil B. , Dahir Nasrin B. , Proszek Paula , Gregory Walter M. , Drayson Mark T. , Jackson Graham H. , Ross Fiona M. , Davies Faith E. , Morgan Gareth J. 
Published: November 2014

Key PointsCoexistent hyperdiploidy or t(11;14) does not abrogate the poor prognosis associated with adverse cytogenetics in myeloma patients. Single-cell analysis reveals that hyperdiploidy may precede IGH translocation in the clonal history of a proportion of patients with both.
Evaluation of the nonsteroidal anti-inflammatory drug-sparing effect of etanercept in axial spondyloarthritis: results of the multicenter, randomized, double-blind, placebo-controlled SPARSE study
Authors: Dougados Maxime , Wood Emily , Combe Bernard , Schaeverbeke Thierry , Miceli-Richard Corinne , Berenbaum Francis , Koppiker Nandan , Dubanchet Arnaud , Logeart Isabelle 
Published: November 2014

Abstract
Introduction
In clinical practice, nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly discontinued after response to biologic therapy is achieved in patients with axial spondyloarthritis (axSpA), but the impact of NSAID discontinuation has not been assessed in prospective controlled trials. The aim of the SPARSE study was to evaluate the effects of the anti-tumor necrosis factor agent etanercept on NSAID intake and conventional clinical outcomes in axSpA patients.

Methods
In the double-blind, placebo-controlled period, patients with active (mini Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥4) axSpA despite optimal NSAID intake were randomized to receive etanercept 50 mg or placebo once weekly for 8 weeks. All patients were advised to taper/discontinue their NSAID intake during the treatment period. NSAID intake was self-reported by diary and Assessment of SpondyloArthritis International Society (ASAS)-NSAID scores calculated based on ASAS recommendations. The primary endpoint was change from baseline to week 8 in ASAS-NSAID score (analysis of covariance).

Results
In 90 randomized patients at baseline, mean age (standard deviation) was 38.9 (11.8) years; disease duration, 5.7 (8.1) years; 59/90 (66%) were human leukocyte antigen-B27 positive; 51/90 (57%) had radiographic sacroiliitis; and 45/90 (50%) were magnetic resonance imaging sacroiliitis-positive. Mean ASAS-NSAID scores were similar between etanercept and placebo groups at baseline (98.2 (39.0) versus 93.0 (23.4)), as were BASDAI (6.0 (1.7) versus 5.9 (1.5)), and Bath Ankylosing Spondylitis Functional Index (5.2 (2.1) versus 5.1 (2.2)). Mean changes (SE) in ASAS-NSAID score from baseline to week 8 were –63.9 (6.1) and –36.6 (5.9) in the etanercept and placebo groups (between-group difference, –27.3; P = 0.002). Significantly higher proportions of patients receiving etanercept versus placebo had an ASAS-NSAID score <10 (46% versus 17%; P = 0.008) and ASAS-NSAID score of 0 (41% versus 14%; P = 0.013) at this time point. Significantly more patients in the etanercept versus placebo group achieved BASDAI50 (39% versus 18%; P = 0.032) and ASAS40 (44% versus 21%; P = 0.028) at week 8.

Conclusions
In patients with axSpA, etanercept was associated with clinically relevant NSAID-sparing effects in addition to significant improvements in conventional clinical outcomes.

Trial registration
ClinicalTrials.gov NCT01298531. Registered 16 February 2011.
Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model
Authors: Kawanishi Yoshitaka , Nakasa Tomoyuki , Shoji Takeshi , Hamanishi Michio , Shimizu Ryo , Kamei Naosuke , Usman Muhammad Andry , Ochi Mitsuo 
Published: November 2014

Abstract
Introduction
The important functions of the meniscus are shock absorption, passive stabilization and load transmission of the knee. Because of the avascularity of two-thirds of the meniscal center region, the treatment of tears in this area is hard. Recently, microRNAs have been proven to play an important role in the pathogenesis of diseases. We focused on microRNA (miR)-210, which plays a wide spectrum of roles comprising mitochondrial metabolism, angiogenesis, DNA repair and cell survival. This study aimed to investigate the effect of intra-articular injection of synthetic miR-210 on the injured meniscus in the avascular zone.

Methods
The middle segments of the medial meniscus of Spraque Dawley rats were incised longitudinally with a scalpel. An intra-articular injection of double-stranded (ds) miR-210 (for control group using control dsRNA) with atelocollagen was administered immediately after injury. Four weeks and 12 weeks after the injection, we conducted a histologic evaluation, immunohistochemical evaluation and Real-time PCR analysis. In vitro, the inner meniscus and synovial cells were isolated from rat knee joint, and were transfected with ds miR-210 or control dsRNA. Real-time PCR and immunohistochemical evaluations were performed.

Results
Twenty-four hours after the injection, FAM (Fluorescein amidite) labeled miR-210 was observed in the cells around the injured site. Four weeks after the injection, the injured site of the miR-210 group was filled with repaired tissue while that of the control was not repaired. In gene expression analysis of the meniscus, the expression of miR-210, Collagen type 2 alpha 1 (Col2a1), Vascular endothelial growth factor (VEGF), and Fibroblast growth factor-2 (FGF2) in the miR-210 group was significantly higher than that in the control. At 12 weeks, the intra-articular injection of miR-210 had healed the injured site of the meniscus and had prevented articular cartilage degeneration. In vitro, miR-210 upregulated Col2a1 expression in the meniscus cells and VEGF and FGF2 expression in the synovial cells.

Conclusions
An intra-articular injection of ds miR-210 was effective in the healing of the damaged white zone meniscus through promotion of the collagen type 2 production from meniscus cells and through upregulated of VEGF and FGF2 from synovial cells.
Optimal surveillance network design: a value of information model
Authors: Convertino Matteo , Liu Yang , Hwang Haejin 
Published: November 2014

Abstract

Purpose
Infectious diseases are the second leading cause of deaths worldwide, accounting for 15 million deaths – that is more than 25% of all deaths – each year. Food plays a crucial role, contributing to 1.5 million deaths, most of which are children, through foodborne diarrheal disease alone. Thus, the ability to timely detect outbreak pathways via high-efficiency surveillance system is essential to the physical and social well being of populations. For this purpose, a traceability model inspired by wavepattern recognition models to detect “zero-patient” areas based on outbreak spread is proposed.

Methods
Model effectiveness is assessed for data from the 2010 Cholera epidemic in Cameroon, the 2012 foodborne Salmonella epidemic in USA, and the 2004-2007 H5N1 avian influenza pandemic. Previous models are complemented by the introduction of an optimal selection algorithm of surveillance networks based on the Value of Information (VoI) of reporting nodes that are subnetworks of mobility networks in which people, food, and species move. The surveillance network is considered the response variable to be determined in maximizing the accuracy of outbreak source detections while minimizing detection error. Surveillance network topologies are selected by considering their integrated network resilience expressing the rewiring probability that is related to the ability to report outbreak information even in case of network destruction or missing information.

Results
Independently of the outbreak epidemiology, the maximization of the VoI leads to a minimum increase in accuracy of 40% compared to the random surveillance model. Such accuracy is accompanied by an average reduction of 25% in required surveillance nodes with respect to random surveillance. Accuracy in systems diagnosis increases when system syndromic signs are the most informative in a way they reveal linkages between outbreak patterns and network transmission processes.

Conclusions
The model developed is extremely useful for the optimization of surveillance networks to drastically reduce the burden of food-borne and other infectious diseases. The model can be the framework of a cyber-technology that governments and industries can utilize in a real-time manner to avoid catastrophic and costly health and economic outcomes. Further applications are envisioned for chronic diseases, socially communicable diseases, biodefense and other detection related problems at different scales.
Predictors of non-diagnostic cytology in surgeon-performed ultrasound guided fine needle aspiration of thyroid nodules
Authors: Isaac Andre , Jeffery Caroline C , Seikaly Hadi , Al-Marzouki Hani , Harris Jeffrey R , O'Connell Daniel A 
Published: December 2014

Background Fine needle aspiration (FNA) is the standard of care for the diagnostic work-up of thyroid nodules but despite its proven utility, the non-diagnostic rate for thyroid FNA ranges from 6-36%. A non-diagnostic FNA is problematic for the clinician and patient because it can result in repeated procedures, multiple physician visits, and a delay in definitive treatment. Surgeon-performed FNA has been shown to be safe, cost-effective, as accurate as those performed by other clinicians, and has the added benefit of decreasing wait times to surgery. Several studies have examined rates and factors that may be predictive of a non-diagnostic cytology in non-surgeon FNA, but none have evaluated this in surgeon-performed thyroid FNA. If these factors are unique in surgeon-performed vs. non-surgeon performed thyroid FNA, then patients may be more appropriately triaged to FNA by alternate clinicians. Objectives The purpose of this study was to determine the rate and factors predictive of a non-diagnostic FNA in surgeon performed ultrasound-guided FNA of thyroid nodules. Methods We conducted a retrospective review of all adult patients who underwent thyroid FNA by a staff, fellow, or resident Otolaryngologist at the University of Alberta between January 2011 and June 2013. Factors analyzed included patient factors, thyroid characteristics, nodule characteristics, and surgeon level of training and experience. Univariate and multivariate binary logistic regression analysis were performed. Results 131 patients (180 nodules) were reviewed. The non-diagnostic rate was 23%. Nodules with predominant cystic component, those less than 1 cm, and resident-performed FNA were associated with non-diagnostic cytology (p = 0.001, p = 0.02, p = 0.04 respectively). A cystic nodule was the only independent predictor of non-diagnostic FNA on multivariate analysis (OR = 4.441, 95% CI [1.785-11.045], p = 0.001). Conclusions The rate of non-diagnostic thyroid FNA performed by a surgeon with ultrasound guidance is similar to other clinicians. A cystic nodule is a strong independent predictor of non-diagnostic cytology. Non-cystic nodules may particularly benefit from surgeon-performed thyroid FNA due to the high diagnostic rate and potential for earlier definitive management.
Βιβλιοκρισία του: ALICIA SIMPSON – STEPHANOS EFTHYMIADIS (επιμ.), Niketas Choniates. A Historian and a Writer, Geneva 2009
Authors: ΠΑΠΑΔΟΠΟΥΛΟΥ Θεοδώρα 
Published: November 2014

Book review: ALICIA SIMPSON – STEPHANOS EFTHYMIADIS, Niketas Choniates. A Historian and a Writer, La Pomme d’Or, Geneva 2009, pp.272+7 plates.
Περί αλφαβητισμού, αιρέσεων, εικονογραφίας και πολιτικών φιλοδοξιών στα μολυβδόβουλλα του Νικηφόρου Βοτανειάτη (περίπου 1001/2-1081)
Authors: ΚΑΡΑΓΙΩΡΓΟΥ Όλγα 
Published: November 2014

<p><span style="font-size: 10pt"><font face="Times New Roman"> </font></span><span style="font-size: 10pt"><font face="Times New Roman">ABOUT LITERACY, HERESY, ICONOGRAPHY AND POLITICAL AMBITION ON THE SEALS OF NIKEPHOROS BOTANEIATES </font></span></p><p><span style="font-size: 10pt"><font face="Times New Roman">The scarce information of the 11th-c. historians on the long military career of Nikephoros Botaneiates before his ascension to the throne is supplemented<span> to a great extent </span>by 31 lead seals of Botaneiates, today kept in private and museum collections in more than seven countries around the world. The epigraphic and iconographic study of this sigillographic material reconstructs the social ascent and military activities of the future emperor, while at the same time it sheds light on his personality (level of culture, religious sensitivities, political ambition) and the socio-political conditions of his era.<span> </span></font></span></p>
Bιβλιοκρισία του: Christos Stavrakos, Alexandra-Kyriaki Wassiliou, Mesrob K. Krikorian, "Hypermachos. Studien zu Byzantinistik, Armenologie und Georgistik".
Authors: ΛΑΜΠΑΚΗΣ Στυλιανός 
Published: November 2014

<p>Book review of the Seibt Festschrift</p><p> </p>
Σακκελίωνος παραλειπόμενα (Συμβολὴ πρώτη)
Authors: ΚΟΜΙΝΗΣ Αθανάσιος Δ. 
Published: November 2014

<p> </p><p> </p><p>A. D. Kominis</p><p>Les Paralipomènes de Sakkelion (Première contribution) </p><p> L'auteur prépare un nouveau catalogue des manuscrits de Patmos. Au cours de ce travail il a noté plusieurs détails importants qui ne figurent pas dans celui, déjà ancien, de Sakkelion. Étant donné que la publication du nouveau catalogue (contenant la description d'environ mille manuscrits) tardera à paraître en entier, l'auteur présente, dans cet article, un premier apport de données nouvelles. Il se limite aux trente premiers manuscrits du catalogue de Sakkelion (mss N° 1-30). Les Paralipomènes consistent en fragments d'évangéliaires, textes hymnographiques ou textes de Pères de l'Église (homélies de Saint-Basile etc.), <em>Apophthegmata Patrum</em>, l'ensemble presque du <em>Pré Spirituel</em> et autres textes, noms divers, dates, notes marginales etc.</p>
Λανθάνον δίφυλλον τοῦ πατμιακοῦ κοντακαρίου 212
Authors: ΚΟΜΙΝΗΣ Αθανάσιος Δ. 
Published: November 2014

<p>A. D. Kominis</p><p> Deux feuillets égarés du kontakarion 212 de Patmos </p><p> L'auteur a retrouvé deux feuillets provenant du <em>kontakarion</em> n° 212 de Patmos. Le contenu, reproduit en entier, comporte des hymnes nouveaux et montre l'importance des manuscrits de Patmos pour l'hymnographie. L'étude codicologique a amené l'auteur à constater que le <em>Patmiacus</em> 212 était initialement composé de 47 quaternions; il en a perdu, avant 1829, 7 quaternions du début et 4 de la fin; ces pertes correspondent à 75-80 hymnes, dont certains étaient transcrits en entier.</p>
Ἱερὰ Μονὴ Κωνσταμονίτου. Κατάλογος τοῦ Ἀρχείου
Authors: ΟΙΚΟΝΟΜΙΔΗΣ Νίκος 
Published: November 2014

<p>N. Oikonomidès</p><p>Catalogue des archives grecques du monastère de Kônstamonitou au Mont Athos (1047-1686) </p><p>Le présent catalogue est le résultat de cinq missions effectuées au Mont Athos en 1966, 1967, 1968 et 1969 et du travail effectué dans les archives du monastère de Saint Stéphane, surnommé tou Kônstamonitou (appellation officielle d'aujourd'hui; le nom ancien est Kastamonitou). L'ensemble des archives (déjà classées et répertoriées suivant d'autres principes par les moines de Kônstamonitou Syméon et Spyridon) a été examiné, la plus ancienne partie (avant 1700) a été photographiée. Les documents anciens ont été classés et rangés dans une armoire métallique, offerte au monastère par la Fondation Royale de la Recherche Scientifique. Les documents turcs antérieurs à l'an 1000 d'Hégire ont également été photographiés; leur étude a été confiée à Elizabeth Zachariadou-Oikonomidès.</p><p>Dans le présent catalogue on a suivi le même système et princi-pes que dans le catalogue des archives grecques de Dionysiou, publié dans Symmeikta I: des notices séparées ont été consacrées à chaque document, avec les éléments suivants: a) type de document: b) date; c) description sommaire; d) résumé; e) <em>incipit </em>; f) indication des éventuelles éditions ou de la bibliographie; g) si nécessaire, notice explicative. L'ensemble a été classé suivant grosso modo le principe de chancelleries: actes des empereurs de Byzance (n° 1-2), actes des patriarches (n° 3-5), actes des prôtoi et du conseil de Karyés (n° 6-16), actes des monastères (n° 17-18) et copies collectives (n° 19-22). A la fin il y a un inventaire des documents classés d'après leur date et un index onomastique.</p>
Παλαιογραφικὰ Ὕδρας
Authors: ΧΡΥΣΟΧΟΪΔΗΣ Κρίτων 
Published: November 2014

<p> </p><p>Κ. Chryssochoidis</p><p>Manuscrits d'Hydra </p><p>L'auteur décrit 24 mss. provenants de collections diverses (monastères de Proph. Ilias et d'Hagia Triada, Métochion de Lavra du Mt. Athos, Archives de la Communauté) de l'île d'Hydra. Le plus ancien ms. date du XVIe siècle. Il faut signaler que les mss. de Proph. Ilias ont un intérêt particulier pour l'étude du mouvement des <em>Kolyvades</em> (XVIIIe-XIXe s.).</p><p> </p><p> </p>