bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research capacity and limitations in Canadian paediatric emergency departments: An observational study on biomarker discovery
Authors: Mitevska Elena , Mickiewicz Beata , Boisvert Leslie , Bon Christine , Carciumaru Redjana , Cook Ramona , Crawford Tyrus , Dietz Joan , Doyle Melanie , Hui Angela Y , Stillwell Karly , Trajtman Adriana , Beer Darcy , Bhatt Maala , Craig William , Fitzpatrick Eleanor , Gravel Jocelyn , Kam April , Mater Ahmed , Moffat Anne , Poonai Naveen , Sabhaney Vikram , Thompson Graham C 
Published: July 2024

Abstract

Background
Paediatric research is essential to acquire effective diagnoses and treatment for children, but it has historically been under-prioritized. The PRIMED study aimed to characterize the bio-profiles of children with appendicitis and investigate their use as a clinical prediction tool. We evaluated the clinical research capacity of several Canadian paediatric emergency departments (EDs) and described both the challenges experienced in the implementation of the PRIMED study and the strategies which were used to improve local research capacity.

Methods
Eleven paediatric EDs across Canada provided basic demographic and administrative data along with laboratory- and human-resource availability during the PRIMED study enrollment. Data were summarized using descriptive statistics.

Results
Fewer than half of the study sites (5/11, 45%) had access to a laboratory that would process research samples 24 hours per day. Four study sites (36%) only enrolled patients during business hours (8:00–17:00). There was no nighttime coverage for patient enrollment and sample collection. Only three study sites (27%) had enrollment hours that captured over 75% of the potential study participants. Over half of the study sites (6/11, 55%) developed novel processes to enable study success, for example, creating graduate student on-call schedules and hiring bioscience-trained site coordinators to process samples.

Interpretation
Despite site-specific efforts to overcome resource barriers, the gap in clinical research capacity at academic paediatric EDs remains a significant concern. University research institutes and paediatric hospitals should invest in infrastructure and human resources to increase after-hours research capacity to optimize child health and wellness outcomes.
Spatial regulation of substrate adhesion directs fibroblast morphotype and phenotype
Authors: D’Urso Mirko , Jorba Ignasi , van der Pol Atze , Bouten Carlijn V C , Kurniawan Nicholas A 
Published: July 2024

Abstract
The switching of the fibroblast phenotype to myofibroblast is a hallmark of a wide variety of tissue pathologies. This phenotypical switch is known to be influenced not only by humoral factors such as TGF-β, but also by mechanical and physical cues in the cellular environment, and is accompanied by distinctive changes in cell morphology. However, the causative link between these cues, the concomitant morphological changes, and the resulting phenotypic switch remain elusive. Here, we use protein micropatterning to spatially control dermal fibroblast adhesion without invoking exogenous mechanical changes and demonstrate that varying the spatial configuration of focal adhesions (FAs) is sufficient to direct fibroblast phenotype. We further developed an automated morphometry analysis pipeline, which revealed FA eccentricity as the primary determinant of cell-state positioning along the spectrum of fibroblast phenotype. Moreover, linear fibronectin patterns that constrain the FAs were found to promote a further phenotype transition, characterized by dispersed expression of alpha-smooth muscle actin, pointing to an interesting possibility of controlling fibroblast phenotype beyond the canonical fibroblast–myofibroblast axis. Together, our study reveals that the spatial configuration of adhesion to the cellular microenvironment is a key factor governing fibroblast morphotype and phenotype, shedding new light on fibroblast phenotype regulation.
Max Bill’s concrete art, as an instrument against irrational thinking and arguments in medicine
Authors: Wolf Gunter 
Published: July 2024

Abstract

Medicine is currently confronted with an increase in irrationality, and non-scientific thinking manifesting in semingly more holistic and natural treatment options, especially in cancer therapy. The Covid-19 pandemic has demonstrated that irrational beliefs are widely spread even among physicians. Max Bill (1908–94) was a Swiss architect, designer, and artist representing an art style called concrete art that focuses on geometrical abstraction and mathematical thinking. December 9, 2024, will be the 30th death anniversary of Max Bill. The following manuscript describes Max Bill’s life and art and tries to offer some suggestions on how his concept of art together with the philosophy of critical rationalism may be excellent instruments to teach medical students and young doctors scientific thinking, and may even be an antidote for irrationality in medicine.
Majorana-Free Bound State in the Continuum in the Double-Channel Fano–Anderson Structure
Authors: Gong Tong , Zhu Yu-Lian , Gong Wei-Jiang 
Published: July 2024

Abstract
We investigate the electron transport through a double-channel Fano–Anderson structure, by considering the side-coupling of Majorana bound states (MBSs). It is found that the bound state in the continuum (BIC) phenomenon can be induced when interchannel dot–lead couplings are identical to the intrachannel dot–lead couplings, whose signature is manifested as a halved quantum transmission ability. If the balance between the dot–lead couplings is broken, the BIC phenomenon will also be destroyed, leading to further suppression of the transmission ability. Next, when MBSs are introduced to this system, the BIC phenomenon can be modified efficiently. For the case of two MBSs side-coupled to the quantum dots in a symmetric way, level degeneracy causes a new BIC phenomenon. As only one MBS is incorporated, it suppresses the electron transmission by inducing new transmission dips. When the interdot Coulomb interaction is considered, the BIC phenomena are still robust despite the complicated changes of the transmission ability spectra. One can then understand the realization of BICs in coupled quantum dots and their variation due to the presence of side-coupled MBSs.
Identifying Deficits in Hip and Knee Muscle Strength on the Surgical and Nonsurgical Sides in Women up to 12 Months After Total Hip Arthroplasty
Authors: Sekita Junya , Takahira Naonobu , Watanabe Hiroyuki , Kusaba Atsushi , Kondo Saiji 
Published: July 2024

Abstract

Objective
Regaining hip and knee muscle strength is important after total hip arthroplasty (THA). However, it is unclear if muscles other than those of the operated hip also lose strength. This study aimed to identify deficits in hip and knee strength on the surgical and nonsurgical sides in female patients up to 12 months after THA.

Methods
Participants were 91 female patients who had hip osteoarthritis and underwent unilateral THA. Forty-six community-dwelling women who were asymptomatic were selected as control participants. Patients with locomotor disorders or postsurgical complications were excluded. Maximal isometric strength of the hip flexors, extensors, and abductors and knee extensors and flexors on the surgical and nonsurgical sides were measured before THA and 3, 6, and 12 months thereafter.

Results
Twelve months after THA, hip flexion, extension, and abduction strength on the surgical side were 84.6%, 83.5%, and 76.2%, respectively, of those in individuals who were asymptomatic; at the same time point, those on the nonsurgical side were 94.8%, 83.9%, and 79.4%, respectively. Knee extension strength on the surgical side was 89.3% of that in individuals who were asymptomatic. Compared to individuals who were asymptomatic, nearly all muscles showed significantly lower strength on both sides up to 6 months after THA.

Conclusion
At 12 months after THA, hip and knee strength on both the surgical and nonsurgical sides did not recover to the level observed in individuals who were asymptomatic. In particular, hip abductor strength on the surgical and nonsurgical sides were 76% and 79%, respectively, of that in individuals who were asymptomatic.

Impact
At 12 months after THA, hip and knee strength on the surgical and nonsurgical sides did not recover to the level observed in individuals who were asymptomatic, suggesting that the nonsurgical side may be inappropriate as a control to assess strength recovery on the surgical side.
Becoming JEDI Warriors in Physical Therapy Research: A Multifaceted Approach
Authors: Papa Evan V , Patel Rupal M , Windsor Nicole , Capo-Lugo Carmen 
Published: July 2024

Abstract

The COVID-19 pandemic and recent incidents of social injustice exposed the systemic racism and discrimination in health care and clinical research that perpetuate systemic inequities. This perspective utilizes the acronym JEDI (justice, equity, diversity, and inclusion) as a vision for addressing inequities in physical therapy research. The need to go beyond diversity and focus on inclusion, equity, and justice is emphasized to achieve transformation within physical therapy research. The prevailing research paradigms are examined, acknowledging that research can perpetuate inequities and reinforcing the importance of integrating JEDI principles into the research process. The underrepresentation of diverse researchers in physical therapy is discussed, as well as the barriers faced by underrepresented researchers and research participants. Funding disparities are also highlighted, emphasizing the need for JEDI principles in research funding practices. How other health professions’ associations are addressing JEDI in research is also explored. The authors propose a framework for action, utilizing the concepts of the socioecological model to identify gaps in JEDI within physical therapy research at different levels of influence and conclude by emphasizing the importance of justice in dismantling inequitable systems and urge the physical therapy research community to become JEDI warriors to bring about transformative change.

Impact
By championing cultures that value justice, equity, diversity, and inclusion, individuals within the physical therapy research community have the potential to ignite a powerful transformation in society. The authors envision a future where JEDI warriors emerge, embracing the spirit of “Do or do not. There is no try,” to forge a research community that is inclusive for all. 1 Drawing inspiration from this mindset, this perspective seeks to empower individuals to harness the force of a JEDI warrior, fostering cultures that value justice, embrace inclusive methodologies, and ensure equitable access to resources and opportunities for researchers and participants.
Working in the Margins: The Untapped Potential of Disability Inclusion
Authors: Herrman Deana , Chambers Emma , Sharp Amanda 
Published: July 2024

Abstract
People with disabilities are considered a historically marginalized population that experiences significant health disparities resulting from the unequal distribution of resources as evidenced in the social determinants of health. Health professions education presents an opportunity to explore the policy, systems, and environmental changes that are needed to improve social conditions and address known disparities for people with disabilities. Evidence suggests that inclusion of learners with diverse lived experiences, including students with disabilities, strengthens our understanding of the influence of social determinants on health and our ability to address known barriers. Unfortunately, people with disabilities and other minoritized individuals are grossly underrepresented in physical therapy. It is imperative that doctor of physical therapy (DPT) education more intentionally promotes the full inclusion of students with disabilities to improve representation and to better support the complex needs of this population. In this perspective, we describe key social determinants of health for people with disabilities, offer strategies for increasing representation and inclusion of students with disabilities in DPT education, and summarize how the inclusion of students with disabilities in DPT education can enhance our understanding of and ability to address social barriers for this population.
Distinctive clinical traits of lupus-related myocarditis: a multicentre retrospective study
Authors: Ramirez Giuseppe A , Holopainen Noora E A , Gerosa Maria , De Luca Giacomo , Bellocchi Chiara , Arroyo-Sánchez Daniel , Sala Simone , Peretto Giovanni , Moroni Luca , Mastropaolo Francesca , Argolini Lorenza M , Pizzetti Giuseppe , Palmisano Anna , Esposito Antonio , Cariddi Adriana , Sartorelli Silvia , Campochiaro Corrado , Beretta Lorenzo , Bozzolo Enrica P , Caporali Roberto , Dagna Lorenzo 
Published: July 2024

Abstract

Objectives
Cardiovascular involvement in systemic lupus erythematosus (SLE) is frequent, but little is known about possible distinctive traits of SLE-related myocarditis (myoSLE) in comparison with patients with SLE (onlySLE) or myocarditis alone (onlyMyo).

Methods
A retrospective analysis was performed comparing patients with myoSLE (n = 25) from three centres with consecutive patients with onlySLE (n = 279) and onlyMyo (n = 88). SLE patients were dichotomized by disease duration ≤1 vs &gt;1 year into recent onlySLE/early myoSLE vs longstanding onlySLE/late myoSLE. Further stratification into disease duration of 1–5, 5–10 and &gt;10 years was also performed. SLE disease activity index 2000 (SLEDAI-2K) was used to estimate disease activity. Myocarditis was diagnosed through biopsy or MRI.

Results
Women were significantly more frequent among myoSLE than among onlyMyo (72% vs 43%; P = 0.013). Compared with onlyMyo, myoSLE patients had a higher frequency of conduction abnormalities (22% vs 5%; P = 0.046) and presented with numerically higher frequencies of left ventricular function compromise (48% vs 30%), along with higher pro-brain natriuretic peptide levels. Inflammation markers were higher in myoSLE compared with onlyMyo and with patients with onlySLE with &gt;10 years of disease duration. SLEDAI-2K was significantly higher in late myoSLE than in longstanding onlySLE. Antiphospholipid syndrome was more frequent in myoSLE than in onlySLE. Multivariate analysis showed an association among myoSLE, anti-β-2-glycoprotein I antibodies (aB2GPI, P = 0.014) and a higher number of involved British Isles Lupus Assessment Group domains in patient history (P = 0.003).

Conclusion
myoSLE has unique clinical traits compared with other forms of myocarditis and is associated with aB2GPI and a more severe SLE course.
Evaluation of orally administered Megasphaera elsdenii in steer calves abruptly transitioned from a receiving diet with 4% dietary starch to a growing diet with 38% dietary starch
Authors: Francis Forest L , Rusche Warren C , Smith Zachary K 
Published: July 2024

Abstract
The objective of this experiment was to evaluate the effects of orally administered Megasphaera elsdenii NCIMB 41125 as a microbial supplement in steers abruptly transitioned from a receiving diet with 4% dietary starch (dry matter [DM] basis) to a growing diet with 38% dietary starch (DM basis). Steers (n = 192; initial shrunk body weight [SBW] = 309 ± 20.6 kg) were assigned to microbial supplement treatment in a randomized complete block design. Treatments were control (CON): no microbial supplement prior to diet transition, and (DFM): microbial supplement orally administered prior to diet transition (20 mL of microbial supplement [Lactipro NXT, Axiota Animal Health, Fort Collins, CO] containing 1 × 1010 colony forming units Megasphaera elsdenii NCIMB 41125). Steers were sourced from a previously conducted 49 d feedlot receiving period experiment and abruptly transitioned from a receiving diet including soybean hulls and wheatlage containing 4% dietary starch (DM basis) to a growing diet including high-moisture ear corn, dry-rolled corn, and wheatlage containing 38% dietary starch (DM basis). Diets were switched on an equal DM intake basis to achieve the abrupt change and steers were fed the 38% starch diet for 49 d until experiment completion. Prior to experiment initiation, steers (n = 72; n = 3/pen) were fitted with wireless rumination tags to track daily activity and rumination time. No differences (P ≥ 0.20) were observed between treatments for final SBW, average daily gain, DM intake, feed efficiency, calculated net energy (NE) for maintenance and gain, or observed-to-expected ratio of NE for maintenance and gain. Additionally, no treatment × day or treatment differences (P ≥ 0.12) were observed for activity or rumination measures. Minutes ruminating and active both differed (P &lt; 0.01) for the main effect of day. Compared to non-supplemented steers, oral administration of Megasphaera elsdenii NCIMB 41125 did not improve growth performance or efficiency of dietary NE utilization in steers transitioned from a receiving diet containing 4% starch (DM basis) to a growing diet containing 38% starch (DM basis).
Rearing hogs on pasture minimally impacts pork composition
Authors: Becker Chelsea , Campbell Jonathan , Soder Kathy , Hines Elizabeth A 
Published: July 2024

Abstract
Managing swine on pasture is increasing in popularity for both the consumer and producer. This interest appears to be driven by an effort to create an improved perception of environmentally sustainable practices and increased animal welfare, while keeping start-up costs low. However, evidence-based guidance on pasture management practices that support quality pork production and environmentally sustainable procedures is lacking. The objective of this work was to quantify the impact of pasture rearing on pig growth efficiency and pork quality. In this pilot study, 20 pigs similar in genetics, age, weight, and sex ratio were divided across indoor (n = 10) and Outdoor (n = 10) housing environments. Pigs were weighed every 14 d and harvested upon reaching an average weight of 113 kg. Average starting body weights were similar between both groups (P = 0.98). Carcass quality was evaluated by measuring pH, loin eye area (LEA), back fat (BF) thickness, subjective color and marbling scores, and colorimetry (CIE color space [L*, a*, b*]) at the 10th rib. Final body weights at slaughter also showed no significant variation between housing groups (P = 0.98). No differences were observed in pork quality: pH 0 h (P = 0.53), 6 h (P = 0.29), 12 h (P = 0.80), and 24 h (P = 0.07) postmortem, LEA (P = 0.44), color (P = 0.73), and marbling (P = 0.40). However, hogs raised indoors had an increase in BF thickness (P = 0.04). Based on this pilot study, outdoor rearing conditions did not have significant impacts on pork quality. Further research will help to determine the impact that rearing scheme has on pH and BF.
A systematic review on Nipah virus: global molecular epidemiology and medical countermeasures development
Authors: Tan Foo Hou , Sukri Asif , Idris Nuryana , Ong Kien Chai , Schee Jie Ping , Tan Chong Tin , Tan Soon Hao , Wong Kum Thong , Wong Li Ping , Tee Kok Keng , Chang Li-Yen 
Published: July 2024

Abstract
Nipah virus (NiV) is an emerging pathogen that causes encephalitis and a high mortality rate in infected subjects. This systematic review aimed to comprehensively analyze the global epidemiology and research advancements of NiV to identify the key knowledge gaps in the literature. Articles searched using literature databases, namely PubMed, Scopus, Web of Science, and Science Direct yielded 5,596 articles. After article screening, 97 articles were included in this systematic review, comprising 41 epidemiological studies and 56 research developments on NiV. The majority of the NiV epidemiological studies were conducted in Bangladesh, reflecting the country’s significant burden of NiV outbreaks. The initial NiV outbreak was identified in Malaysia in 1998, with subsequent outbreaks reported in Bangladesh, India, and the Philippines. Transmission routes vary by country, primarily through pigs in Malaysia, consumption of date palm juice in Bangladesh, and human-to-human in India. However, the availability of NiV genome sequences remains limited, particularly from Malaysia and India. Mortality rates also vary according to the country, exceeding 70% in Bangladesh, India, and the Philippines, and less than 40% in Malaysia. Understanding these differences in mortality rate among countries is crucial for informing NiV epidemiology and enhancing outbreak prevention and management strategies. In terms of research developments, the majority of studies focused on vaccine development, followed by phylogenetic analysis and antiviral research. While many vaccines and antivirals have demonstrated complete protection in animal models, only two vaccines have progressed to clinical trials. Phylogenetic analyses have revealed distinct clades between NiV Malaysia, NiV Bangladesh, and NiV India, with proposals to classify NiV India as a separate strain from NiV Bangladesh. Taken together, comprehensive OneHealth approaches integrating disease surveillance and research are imperative for future NiV studies. Expanding the dataset of NiV genome sequences, particularly from Malaysia, Bangladesh, and India will be pivotal. These research efforts are essential for advancing our understanding of NiV pathogenicity and for developing robust diagnostic assays, vaccines and therapeutics necessary for effective preparedness and response to future NiV outbreaks.
Does Aid Induce Foreign Direct Investment: Updated Evidence from a Quasi-Experiment
Authors: Tian Junyan 
Published: July 2024

Abstract
While the catalytic effect of aid on foreign direct investment (FDI) has long been an implicit consensus among many policymakers and practitioners, assessments of this causal relationship remain limited and are not always reliable. To mitigate this evidence gap, this study applies an instrumental variable approach that leverages the graduation of the International Development Association (IDA) income threshold as a quasi-experiment to identify the causal linkage between foreign aid and FDI. The analysis reveals that a 1 percent drop in the ratio of aid to gross national income leads to a decline in FDI relative to gross domestic product by 0.9 percent in 42 developing countries from 1987 to 2019. In face of the aid shock induced by IDA graduation, governments in recipient countries restrict their financial policy openness, through which aid could significantly impact subsequent foreign private investment. Results emphasize the necessity of concerted policy interventions to mitigate this negative aid shock.