bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large Lamellar Corneoscleral Grafts: Tectonic Role in Initial Management of Severe Ocular Chemical Injuries
Authors: Iyer Geetha , Srinivasan Bhaskar , Rishi Ekta , Rishi Pukhraj , Agarwal Shweta , Subramanian Nirmala 
Published: June 2015

Purpose To report the outcome of large tectonic lamellar grafts in cases of severe chemical injury associated with corneal melt/perforation and scleral ischemia, with or without retinal detachment. Methods This was a retrospective interventional analysis of 7 eyes of 6 patients within 3 months of injury with simultaneous/subsequent surgical procedures to salvage globe integrity. Results Of 7 included eyes, both eyes of one patient underwent phthisical changes. In one eye, the retinal detachment was inoperable; in another, the retina was reattached with silicone oil tamponade, and underwent subsequent Boston type 1 keratoprosthesis with a final best-corrected visual acuity of 20/80 at 3-year follow-up. One eye underwent Lucia type 2 keratoprosthesis, one eye the modified osteo-odonto keratoprosthesis procedure, with visual recovery of 20/120 and 20/80, respectively, and one maintained vision of 20/200 for 2 years following a penetrating keratoplasty. The final best-corrected visual acuity was better than 20/200 in 4 out of these 7 eyes (57.14%). Conclusions In acute severe chemical injuries, corneal perforation with scleral ischemia can threaten globe integrity as well as preclude routine tectonic penetrating procedure. Presence of a concurrent retinal detachment in this setting further complicates the approach as well as the outcome. The use of a large tectonic corneoscleral lamellar graft provides a viable option in the achievement of tectonic stability in these eyes, facilitating future visual rehabilitative procedures.
Early Results of Dexamethasone Implant, Ranibizumab, and Triamcinolone in Macular Edema Due to Branch Retinal Vein Occlusion
Authors: Yumusak Erhan , Buyuktortop Nesrin , Ornek Kemal 
Published: June 2015

Purpose To compare the short-term results of the efficacy and safety of dexamethasone intravitreal implant (DEX), ranibizumab (RAN), and intravitreal triamcinolone acetonide (IVTA) in macular edema secondary to branch retinal vein occlusion (BRVO). Methods One eye each of 32 patients who were treated with intravitreal injections for macular edema secondary to BRVO was studied. This retrospective study included 3 groups. The patients received DEX in group 1 (n = 11), RAN in group 2 (n = 11), and IVTA in group 3 (n = 10). Data were collected before and after the injections at the first and third months. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure (IOP) were analyzed statistically. Results The median duration of the follow-up was 3.0 months in overall groups. The BCVA increased significantly in all groups (p = 0.018, p = 0.034, p = 0.014, respectively). The CMT increased significantly in groups 1 and 3 (p = 0.02, p<0.001, respectively), but not in group 2 (p = 0.14). The IOP increased significantly in groups 1 and 3 (p = 0.05, p<0.001, respectively). Antiglaucomatous treatment was required only in group 3. Cataract developed in 2 patients (20%) in group 3 and surgery was required. Conclusions Although RAN was the safest among the 3 agents, DEX and IVTA reduced CMT more than RAN, while significant improvement was achieved in BCVA in all groups. All 3 agents can be effectively used in the treatment of macular edema due to BRVO.
Quantitative Evaluation of Visual Function 12 Months after Bilateral Implantation of a Diffractive Trifocal IOL
Authors: Marques João P. , Rosa Andreia M. , Quendera Bruno , Silva Fátima , Mira Joaquim , Lobo Conceição , Castelo-Branco Miguel , Murta Joaquim N. 
Published: June 2015

Purpose To quantitatively evaluate visual function 12 months after bilateral implantation of the Physiol FineVision® trifocal intraocular lens (IOL) and to compare these results with those obtained in the first postoperative month. Methods In this prospective case series, 20 eyes of 10 consecutive patients were included. Monocular and binocular, uncorrected and corrected visual acuities (distance, near, and intermediate) were measured. Metrovision® was used to test contrast sensitivity under static and dynamic conditions, both in photopic and low-mesopic settings. The same software was used for pupillometry and glare evaluation. Motion, achromatic, and chromatic contrast discrimination were tested using 2 innovative psychophysical tests. A complete ophthalmologic examination was performed preoperatively and at 1, 3, 6, and 12 months postoperatively. Psychophysical tests were performed 1 month after surgery and repeated 12 months postoperatively. Results Final distance uncorrected visual acuity (VA) was 0.00 ± 0.08 and distance corrected VA was 0.00 ± 0.05 logMAR. Distance corrected near VA was 0.00 ± 0.09 and distance corrected intermediate VA was 0.00 ± 0.06 log-MAR. Glare testing, pupillometry, contrast sensitivity, motion, and chromatic and achromatic contrast discrimination did not differ significantly between the first and last visit (p>0.05) or when compared to an age-matched control group (p>0.05). Conclusions The Physiol FineVision® trifocal IOL provided satisfactory full range of vision and quality of vision parameters 12 months after surgery. Visual acuity and psychophysical tests did not vary significantly between the first and last visit.
Correlation of Spectral-Domain Optical Coherence Tomography with Fundus Fluorescein Angiography in an Infant with Retinal Hamartomas
Authors: Chidambara Lavanya , Jayadev Chaitra , Mangalesh Shwetha , Sivakumar Munusamy , Shetty Bhujang , Vinekar Anand 
Published: June 2015

Purpose To describe the correlation between the surface morphology on spectral-domain optical coherence tomography (SD-OCT) and leakage pattern on fundus fluorescein angiography (FFA) in an infant with multiple retinal hamartomas. Methods An Asian Indian female infant was found to have 2 retinal lesions in the right eye and 1 in the left eye during Retcam (Clarity MSI, CA, USA) screening for retinopathy of prematurity at 45 weeks postmenstrual age. Spectral-domain optical coherence tomography on the hand-held OCT (Envisu 2300, Bioptigen, NC, USA) and FFA on the Retcam 3 were performed under monitoring in the office. Results Spectral-domain OCT detected all 3 lesions but only 1 lesion was detected on FFA. While this lesion had an irregular surface with overlying vitreoretinal (VR) traction on SD-OCT, the other 2 lesions not detected on FFA were smooth and had no VR traction. After a follow-up to 18 months corrected age, there was no change in the morphology of any of the lesions. Conclusions It is possible to characterize retinal hamartomas in infants using SD-OCT and correlate them with FFA. Spectral-domain OCT examination can be used to diagnose and monitor lesions even if they are not detectable on angiography.
Endophthalmitis Today: A Multispecialty Ophthalmology Department Perspective
Authors: Ben Artsi Elad , Katz Gabriel , Kinori Michael , Moisseiev Joseph 
Published: June 2015

Purpose To portray the current scene of endophthalmitis in a multispecialty ophthalmology department regarding etiologies and treatment guidelines. Methods Retrospective chart review of all patients diagnosed with endophthalmitis or suspected endophthalmitis from 2009 to 2012. Results A total of 24 eyes were diagnosed with endophthalmitis or suspected endophthalmitis during a 4-year period. The etiologies included endogenous endophthalmitis ( 6 ), blebitis ( 3 ), Ahmed valve implantation (3, 2 of them with late infection), postcataract surgery ( 3 ), intravitreal injections ( 4 ), penetrating injury ( 2 ), and other surgical procedures ( 3 ). Of the postcataract surgery cases, 1 was a congenital cataract surgery, and 2 were referrals. There were no endophthalmitis cases in 4603 adults undergoing cataract surgery in our department during this period. There were 14 positive cultures: 1 was candida and the rest bacteria. Ten of the bacteria cases were Gram-positive cocci (predominantly strep species), 3 were Gram-negative, and coagulase negative staphylococci were detected in 2 cases. Conclusions Our study indicates a significant change in the case mix of endophthalmitis. The past leading cause, cataract surgery, was dramatically reduced, and intravitreal injections became a major cause. The change in etiologies, and possibly in the microbial flora, warrants reconsideration of the rules that guided the management of endophthalmitis since the Endophthalmitis Vitrectomy Study.
Predicting High Blood Metal Ion Concentrations following Hip Resurfacing
Authors: Matharu Gulraj S. , Berryman Fiona , Brash Lesley , Pynsent Paul B. , Treacy Ronan B.C. , Dunlop David J. 
Published: June 2015

Purpose To determine whether gender, femoral head size, acetabular inclination, and time since surgery predicted high blood metal ion concentrations following Birmingham Hip Resurfacing (BHR). Methods BHR patients with unilateral bearings at one specialist centre with blood cobalt and chromium concentrations measured up to May 2013 were included. This comprised a mixed (at-risk) group including symptomatic patients and asymptomatic individuals with specific clinical and/or radiological findings. Blood sampling was at a mean of 7.5 years (range 1-15.4 years) postoperatively. Results Of 319 patients (mean age 49.3 years; 53% male), blood metal ions greater than 7 µg/l were observed in 9% (n = 28). Blood metal ions were significantly higher in females (p<0.001), femoral head sizes ≤48 mm (p<0.01), and cup inclinations >55° (p<0.001). Linear regression demonstrated femoral head size was responsible for the highest proportion of variance in blood metal ions (cobalt p<0.001, R2 = 8%; chromium p<0.001, R2 = 11%). Analysis of femoral head size and inclination together demonstrated 36% of BHRs with head sizes of 38-44 mm and inclination >55° had blood metal ions >7 µg/l. BHR 10-year survival for this at-risk group was 91% (95% confidence intervals 86.0%-95.0%) with 30 hips revised. Conclusions If blood metal ions are used to screen hip resurfacing patients for adverse reactions to metal debris it is recommended those with small femoral head sizes (38-44 mm) and high acetabular inclinations (>55°) are targeted. These findings require validation in other cohorts as they may not be applicable to all hip resurfacing devices given the differences in radial clearance, coverage arc, and metallurgy.
Late Onset Imminent Femoral Fatigue Fracture Associated with Intraoperative Cement Extrusion as a Rare Cause of Thigh Pain after Total Hip Replacement
Authors: Antoniadis Alexander , Zingg Patrick O. , Dora Claudio 
Published: June 2015

Introduction Cement extrusions on the femoral side after total hip replacement can occur in approximately 0.3% of cemented primary total hip replacements. Not recognised until a postoperative x-ray is performed, the willingness to dismiss and treat these extrusions conservatively is high. Methods We report on 3 patients presenting with sudden onset of thigh pain associated with an inability to weight-bear after a 2 to 15 month period of uneventful healthy recovery from cemented total hip replacement. On immediate postoperative x-rays occult cement extrusion in the posterolateral circumference of the femoral component tip were present. X-rays and CT scans showed no fracture signs. Scintigraphy revealed late increased uptake at the extrusion height. With the hypothesis of imminent femoral fatigue fracture, all patients underwent revision surgery. The defect sites were surgically exposed, thoroughly cleaned of cement, filled with iliac crest bone graft and stabilised with tension band plating. Results This procedure resulted in fully recovered asymptomatic patients at 6 weeks and after a mean follow-up period of 48 months, as demonstrated by their pain level and tolerance of full weight bearing. Conclusions These cases lead us to adopt a low threshold for immediate revision when occult cement extrusion is recognised near the tip of a cemented stem on postoperative films, and to adopt a low threshold for surgical revision when, in the presence of cement extrusion, thigh pain is a complaint. We favour tension band plating and bone grafting over more complex implant revisions since a fast recovery was achieved in these patients.
Outcome of the Stryker® Trident ‘All-Poly’ Constraint Acetabular Insert: A District General Hospital Experience
Authors: Harrison Simon J. , Leeder Daniel J. , McWilliams Timothy G. , Metcalf Robert W. , Sidhom Sameh A. 
Published: June 2015

Introduction Constrained acetabular inserts are designed as revision solutions for unstable total hip arthroplasties to prevent dislocation and as a possible primary option for elderly patients at risk of recurrent dislocation. Purpose Our aim was to establish clinical and radiological outcomes of an ‘all-poly’ constrained acetabular device and to highlight reasons for component failure. Methods We retrospectively reviewed our use of the Stryker® Trident ‘all-poly’ constrained acetabular insert between 2008 and 2013. All inserts were cemented directly into the acetabulum. Demographic data was collated. The indication for use of a constrained insert and postoperative complications were determined. Patients were reviewed clinically and underwent radiographic follow-up. Results A total of 56 constrained inserts were utilised during the study period. Follow-up was for a minimum of 2 years (mean 4.0 years and range 2.0-6.8 years). The mean latest follow-up Oxford hip score was 34.6 (11-48). One postoperative superficial wound infection, 1 breakage of the constraining ring without clinical consequence and 1 recognised complication of liner failure at the bipolar interface were noted. Conclusions In the short to medium term, acetabular constraint offers a useful primary or revision option in patients at risk or with recurrent dislocation.
Lean Body Mass Assessment Based on UV Absorbance in Spent Dialysate and Dual-Energy X-Ray Absorptiometry
Authors: Tomson Ruth , Fridolin Ivo , Luman Merike 
Published: June 2015

Purpose The aim of the study was to explore the possibility of assessing lean body mass (LBM) based on UV absorbance measurements in spent dialysate. Methods 9 patients on chronic three-times-a-week HD (4 female, 5 male, mean age 58.8 ± 8.6 years) were studied. Blood and spent dialysate samples were collected for 3 consecutive hemodialysis (HD) sessions from every patient. A double-beam spectrophotometer was used for the determination of UV absorbance in the collected spent dialysate samples. Dual-energy x-ray absorptiometry (DXA) scans were performed on an interdialytic day. LBM was calculated based on creatinine concentration in blood (LBMblood) and UV absorbance in spent dialysate (LBMa) and assessed by DXA (LBMDXA). Also, in vitro experiments were carried out to investigate the effect of tissue hydration on DXA measurements. Results Although LBMa was slightly lower compared to LBMblood, the estimates based on UV absorbance in spent dialysate presented greater accuracy and precision compared to LBMDXA. The significant difference between LBMblood and LBMDXA was with high probability caused by the altered tissue hydration of HD patents. Conclusions In summary, the results show that it is possible to asses LBM based on UV absorbance in spent dialysate.
Mechanical and Biocompatibility Performance of Bicomponent Polyester/Silk Fibroin Small-Diameter Arterial Prostheses
Authors: Yang Xiaoyuan , Wang Lu , Guan Guoping , Zhang Hongqi , Shen Gaotian , Guan Ying , Peng Lei , Li Yuling , King Martin W. 
Published: June 2015

Background In this study, we fabricated prototype bicomponent polyester/silk fibroin small-diameter arterial prostheses using a specially designed narrow ribbon shuttle loom. Methods The 2-layered flat fabrics were then heatset on a mandrel to form tubes with a round cross section. Results The woven samples had a wall thickness between 0.23 mm and 0.29 mm and an inner diameter between 3.53 mm and 3.95 mm, depending on the yarn type and the weave structure. Conclusions The bicomponent polyester/silk fibroin samples had superior bursting strength, circumferential strength and suture retention strength compared with a commercial small-diameter arterial prosthesis made from ePTFE. In addition, these prototype samples had greater suture retention strengths than a dog femoral artery, which indicates that they have adequate biostability for clinical use. While their amount of radial compliance was superior to that of the ePTFE commercial graft control, it did not match that of a natural artery. So there is still a need for future improvement in compliance. All of the woven prototypes had water permeability values between 26 and 180 ml/(cm2*min), which confirms that none of these arterial prostheses needs to be preclotted at the time of implantation. The biocompatibility of the woven prototypes was evaluated using porcine endothelial cells and an MTT assay. Their cytocompatibility was found to be superior to the ePTFE commercial control, and the level of cell attachment was observed to increase on these prototypes woven with a higher silk fibroin content.
Effects of Nanofillers on Mechanical Properties of Fiber-Reinforced Composites Polymerized with Light-Curing and Additional Postcuring
Authors: Scribante Andrea , Massironi Sarah , Pieraccini Giulia , Vallittu Pekka , Lassila Lippo , Sfondrini Maria Francesca , Gandini Paola 
Published: June 2015

Background The purpose of the present study was to evaluate the effect of nanofillers on the mechanical properties of 2 sizes (diameters 0.6 and 0.9 mm) of conventional and nanofilled fiber-reinforced composites (FRCs) polymerized with conventional light-curing and additional postcuring. Methods The FRCs samples were divided into 8 groups (10 specimens each). Conventional FRCs with glass fibers preimpregnated with polymethyl methacrylate (groups 1, 2, 3 and 4) and FRCs with impregnating solution containing 32% nanofilled resin (groups 5, 6, 7 and 8) were tested in 2 different sections (0.6 and 0.9 mm in diameter). Two different polymerizations were analyzed: hand light-curing for 40 seconds with an halogen light, and additional postcuring for 25 minutes in a light-curing oven. Each sample was evaluated with a 3-point bending test on a universal testing machine, after 48 hours of dry storage. All of the data were statistically analyzed. Results After oven postcuring, nanofilled FRCs exhibited significantly higher load values than conventional FRCs. No significant differences were found when comparing conventional and nanofilled FRCs after hand light-curing. Moreover, 0.6-mm FRCs showed significantly lower load values than 0.9-mm FRCs, both for conventional and nanofilled FRCs. Conclusions Nanofilled FRCs showed higher load values after additional oven postcuring.
Color Match of Resin Composites to Intact Tooth Structure
Authors: Mourouzis Peter , Koulaouzidou Elisabeth A. , Palaghias Georgios , Helvatjoglu-Antoniades Maria 
Published: June 2015

Introduction The optical properties of dental restorative materials have a dramatic effect on patient esthetics, which may be compromised by the poor blending effect of composites resins at the composite–tooth interface. Objective The objective of this study was to evaluate the color-matching ability and the blending effects of 3 different composite resins when restoring natural teeth. Methods Three commercially available composites and 60 central incisors were used for this experiment. Each tooth was sectioned horizontally at the level of the cementum–enamel junction, and the crown was then bisected along the long axis of the tooth. One half of each tooth was restored individually with composite resin, after matching with the corresponding tooth shade. The tooth color was evaluated preoperatively and postoperatively using an intraoral spectrophotometer and a scientific spectrophotometer. Color differences were then evaluated by the CIEDE2000 color difference formula. Results The results showed the existence of color differences between the intact and the restored sections of the teeth. However, these differences were considered acceptable, since the ΔΕ value ranged below 3.3. The ΔE, Δa and Δb parameters showed no statistically significant differences between the groups (p>0.05). Conclusions The 3 composites tested were able to mimic natural teeth and produce acceptable restorations. However, the color of the resin composites needs to be evaluated over the long term, because it is subject to alterations in the oral environment over time.
Meta-Analysis of Microarrays: Diagnostic value of microRNA-21 as a Biomarker for Lung Cancer
Authors: Meng Xinxin , Xiao Chen , Zhao Yuguang , Jia Lin , Tang Yang , Li Dan 
Published: June 2015

Background: MicroRNA-21 (miR-21) has previously been demonstrated as a potential biomarker in diagnosis of various human tumors. This meta-analysis was performed to evaluate the possibility of miR-21 as a biomarker for early detection of lung cancer. Methods: Relevant lung cancer-related miRNA microarray datasets were collected from the NCBI Gene Expression Omnibus (GEO) database and EBI ArrayExpress database up to February 2014. Quality control of the output data was estimated using Limma package and ExiMiR package in R. Standardized mean difference (SMD) with 95% confidence intervals (CIs) from selected datasets was pooled. Heterogeneity was assessed using Cochran's Q test and the I2 statistic, and a p value <0.0.05 or I2 >50% was defined as significant heterogeneity. Furthermore, sensitivity analysis was conducted to evaluate the stability of the pooled results. Four miRNA datasets (GSE24704, GSE17681, GSE27486 and GSE40738) from blood samples were selected, including 153 lung cancer patients and 109 healthy people. Results: The pooled results generated by random-effects model revealed that no significant difference was observed between case and control groups (SMD = 0.58; 95% CI, −0.04 to 1.19; p = 0.07) with significant heterogeneity (p = 0.0032, I2 = 78.2%; p = 0.06). Sensitivity analysis indicated that the results of the meta-analysis were stable. Conclusions: MiR-21 expression levels in whole blood and peripheral blood cells did not show significant differences between lung cancer patients and healthy controls, and it might be ineffective to measure miR-21 expression to achieve an early diagnosis of lung cancer.
Absolute Circulating Pericyte Progenitor Cell Counts in Mice by Flow Cytometry: comparison of 2 single-platform technologies
Authors: Yuan Xiaochen , Wu Qingbin , Li Hongwei , Li Bingwei , Xiu Ruijuan 
Published: June 2015

Background Accumulating evidence indicates that circulating pericyte progenitor cells (CPPCs) may be angiogenic biomarkers in cancer and diabetes. Their validity as biomarkers depends on the accuracy of techniques used for enumeration. In this report, absolute CPPC counts were performed by 2 single-platform technologies. The reliability of the 2 methods, including retest reliability and intraobserver and interobserver variability, was assessed according to the intraclass correlation coefficient (ICC). The linear correlation and agreement among both methods were assessed, and the stability of CPPC numbers in blood samples was analyzed. Methods The blood samples were obtained from ICR mice. The samples were processed through a no-lyse, 1-wash procedure, and Syto16+CD45-CD31-CD140b+ CPPCs were analyzed by exclusion of dead cells and by fluorescence-minus-one control. CPPCs were enumerated by 2 methods: bead-based 123count eBeads count (eBioscience) and direct volume–based Accuri C6 Flow Cytometer count (BD). The cells were measured immediately and after storage of blood samples for 24 and 48 hours. Results There were excellent retest correlations and intraobserver and interobserver agreement in both methods. The 2 methods showed a high linear correlation (R2 = 0.923) and with a high level of agreement (0.986). It was demonstrated that CPPCs are unstable in blood samples. Conclusions In this study, 2 reproducible protocols for CPPC quantification were established. These protocols should facilitate future studies to further define the role of CPPCs as cellular biomarkers.