bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posttraumatic Growth in Breast Cancer Survivors: Constructive and Illusory Aspects
Authors: Pat‐Horenczyk Ruth , Perry Shlomit , Hamama‐Raz Yaira , Ziv Yuval , Schramm‐Yavin Sarit , Stemmer Salomon M. 
Published: May 2015

AbstractThis study investigated the impact of a building‐resilience intervention on coping and posttraumatic growth (PTG) in a convenience sample of 94 breast cancer survivors. PTG was divided into constructive and illusory components, based on the two‐sided Janus face model (Maercker & Zoellner, 2004). We operationalized constructive PTG as an improvement in both PTG and coping, and illusory PTG as an improvement in PTG only. An 8‐session group intervention was delivered to 49 women (mean age = 51.5 years, SD = 10.7) who completed self‐report questionnaires at baseline and at 6 months follow‐up; a control group of 45 women only completed questionnaires. More than half the participants (n = 53; 56.38%) reported increased PTG at 6 months (mean change = 0.56, SD = 0.48, η2 = .58). The increase in both PTG and positive coping was significantly greater in the intervention group than the control group (B = 0.23 for PTG, and B = 0.35 for positive coping). Further, a higher proportion of constructive PTG (vs. illusory PTG) was reported by the participants in the intervention group (89.3%), as compared to the control group (56.3%; z = 2.57). The distinction between constructive and illusory PTG has clinical implications for interventions promoting coping and growth among cancer survivors.
Characterization of the peak at 2.06 ppm in 31P magnetic resonance spectroscopy of human liver: phosphoenolpyruvate or phosphatidylcholine?
Authors: Bierwagen Alessandra , Begovatz Paul , Nowotny Peter , Markgraf Daniel , Nowotny Bettina , Koliaki Chrysi , Giani Guido , Klüppelholz Birgit , Lundbom Jesper , Roden Michael 
Published: May 2015

High field MR scanners can resolve a metabolite resonating at 2.06 ppm in the in vivo proton‐decoupled liver 31P MR spectrum. Traditionally this peak has been assigned to phosphoenolpyruvate (PEP), the key metabolite for gluconeogenesis. However, recent evidence supported the assignment to biliary phosphatidylcholine (PtdCh), which is produced in the liver and stored in the gall bladder.To elucidate the respective contributions of PtdCh and PEP to the in vivo resonance at 2.06 ppm (PEP–PtdCh), we made phantom measurements that confirmed that both biliary PtdCh and PEP resonate approximately at 2 ppm. The absolute quantification of PEP–PtdCh yielded concentrations ranging from 0.6 to 2.0 mmol/l, with mean coefficients of variation of 4.8% for intraday and 7.2% for interday reproducibility in healthy volunteers. The T1 relaxation time of PEP–PtdCh was 0.97 ± 0.30 s in the liver and 0.44 ± 0.11 s in the gallbladder. Ingestion of a mixed meal decreased the concentration of PtdCh‐PEP by approximately 12%.In the retrospective analysis, PEP–PtdCh was 68% higher in the liver of subjects with gallbladder infiltration of the volume of interest (VOI) compared with those without gallbladder infiltration. PEP–PtdCh was also significantly higher in the liver of cholecystectomy patients compared with volunteers without gallbladder infiltration, which suggests increased intrahepatic bile fluid as a compensation for gall bladder removal.These results show that liver PtdCh is the major component of the resonance at 2.06 ppm and that careful VOI positioning is mandatory to avoid interference from the gallbladder. Copyright © 2015 John Wiley & Sons, Ltd.
Glass‐based Manufacturing and Prototyping Platform PhotPack
Authors: Böttger Gunnar , Seifert Stefan , Schröder Henning 
Published: May 2015

AbstractThere has been considerable progress in utilizing fully automated machines for the assembly of micro‐optical systems in recent years. Such systems integrate laser sources, passive optical elements, electro‐optical components and detectors into tight packages, and efficiently couple light to waveguides in photonic integrated circuits (PIC), optical backplanes, free space or optical fibers. The required electro‐optical and optical components are placed and aligned passively and actively, depending on optical and mechanical component tolerances. For one, the relative placing of all components is controlled actively by camera systems, and, more importantly, some or all active components are actually operated, and actively aligned with live feedback from internal and external power and beam image detectors. High precision (and also fast) active optical alignment machines nowadays exist, with more than adequate degrees of freedom and accuracies, so that best optical beam qualities and coupling efficiencies can be achieved.
Causing a Q‐Motion
Authors: Dreissigacker Oliver 
Published: May 2015

AbstractOptik & Photonik was given a behind the scenes insight in the developers wing of PI's (Physik Instrumente) headquarters in Karlsruhe, south‐west Germany. PI is a global market and technology leader in the field of precision positioning technology and we had the opportunity to record a video interview with engineer Mark Freyer, Product Division Head for Piezoelectric Inertia Drives at PI.
Epigenetic down‐regulation of integrin α7 increases migratory potential and confers poor prognosis in malignant pleural mesothelioma
Authors: Laszlo Viktoria , Hoda Mir Alireza , Garay Tamas , Pirker Christine , Ghanim Bahil , Klikovits Thomas , Dong Yawen W , Rozsas Anita , Kenessey Istvan , Szirtes Ildiko , Grusch Michael , Jakopovic Marko , Samarzija Miroslav , Brcic Luka , Kern Izidor , Rozman Ales , Popper Helmut , Zöchbauer‐Müller Sabine , Heller Gerwin , Altenberger Corinna , Ziegler Barbara , Klepetko Walter , Berger Walter , Dome Balazs , Hegedus Balazs 
Published: May 2015

AbstractMalignant pleural mesothelioma (MPM) is a devastating malignancy characterized by invasive growth and rapid recurrence. The identification and inhibition of molecular components leading to this migratory and invasive phenotype are thus essential. Accordingly, a genome‐wide expression array analysis was performed on MPM cell lines and a set of 139 genes was identified as differentially expressed in cells with high versus low migratory activity. Reduced expression of the novel tumour suppressor integrin α7 (ITGA7) was found in highly motile cells. A significant negative correlation was observed between ITGA7 transcript levels and average displacement of cells. Forced overexpression of ITGA7 in MPM cells with low endogenous ITGA7 expression inhibited cell motility, providing direct evidence for the regulatory role of ITGA7 in MPM cell migration. MPM cells showed decreased ITGA7 expressions at both transcription and protein levels when compared to non‐malignant mesothelial cells. The majority of MPM cell cultures displayed hypermethylation of the ITGA7 promoter when compared to mesothelial cultures. A statistically significant negative correlation between ITGA7 methylation and ITGA7 expression was also observed in MPM cells. While normal human pleura samples unambiguously expressed ITGA7, a varying level of expression was found in a panel of 200 human MPM samples. In multivariate analysis, ITGA7 expression was found to be an independent prognostic factor. Although there was no correlation between histological subtypes and ITGA7 expression, importantly, patients with high tumour cell ITGA7 expression had an increased median overall survival compared to the low‐ or no‐expression groups (463 versus 278 days). In conclusion, our data suggest that ITGA7 is an epigenetically regulated tumour suppressor gene and a prognostic factor in human MPM. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Effect of hydrothermally synthesized titanium nanotubes on the behaviour of polypropylene for antimicrobial applications
Authors: Zenteno Andrés , Guerrero Sichem , Ulloa María Teresa , Palza Humberto , Zapata Paula A 
Published: May 2015

AbstractTiO2 nanotubes (TiO2‐Ntbs) synthesized by a hydrothermal method were used as filler to prepare polypropylene (PP) composites by melt blending. Their structural properties as well as their biocidal potential were studied. Nanotubes were used either as‐synthesized or organically modified with hexadecyltrimethoxysilane (Mod‐TiO2). These nanoparticles form secondary structures with sizes around 100 nm that are well dispersed in the polymer matrix, but not homogeneously because agglomerates larger than 1 µm are also seen by transmission electron microscopy. Regarding the properties of the composites, the incorporation of the nanoparticles increased the polymer's crystallinity and thermal stability. The maximum decomposition temperature of the matrix increased by ca 13 °C compared to virgin PP. The nanotubes further increase the spherulite nucleation density, and therefore a reduction in the diameter of spherulites and an increase in their number were observed. Despite the above, the addition of TiO2 nanoparticles did not modify the mechanical properties of PP. The PP/TiO2‐Ntb nanocomposites exposed to UVA radiation showed a biocidal behaviour, reducing a colony of Escherichia coli by 81%. © 2015 Society of Chemical Industry
A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors
Authors: Di Marino Daniele , D'Annessa Ilda , Tancredi Holly , Bagni Claudia , Gallicchio Emilio 
Published: May 2015

AbstractThe interaction between the eukaryotic translation initiation factor 4E (eIF4E) and eIF4E binding proteins (4E‐BP) is a promising template for the inhibition of eIF4E and the treatment of diseases such as cancer and a spectrum of autism disorders, including the Fragile X syndrome (FXS). Here, we report an atomically detailed model of the complex between eIF4E and a peptide fragment of a 4E‐BP, the cytoplasmic Fragile X interacting protein (CYFIP1). This model was generated using computer simulations with enhanced sampling from an alchemical replica exchange approach and validated using long molecular dynamics simulations. 4E‐BP proteins act as post‐transcriptional regulators by binding to eIF4E and preventing mRNA translation. Dysregulation of eIF4E activity has been linked to cancer, FXS, and autism spectrum disorders. Therefore, the study of the mechanism of inhibition of eIF4E by 4E‐BPs is key to the development of drug therapies targeting this regulatory pathways. The results obtained in this work indicate that CYFIP1 interacts with eIF4E by an unique mode not shared by other 4E‐BP proteins and elucidate the mechanism by which CYFIP1 interacts with eIF4E despite having a sequence binding motif significantly different from most 4E‐BPs. Our study suggests an alternative strategy for the design of eIF4E inhibitor peptides with superior potency and specificity than currently available.
Formation of hydroxylapatite on CVD deposited titania layers
Authors: Baryshnikova Marina , Filatov Leonid , Mishin Maxim , Kondrateva Anastasia , Alexandrov Sergey 
Published: May 2015

AbstractBioactive coatings on medical implants can be prepared from titanium dioxide due to its ability to induce the formation of hydroxylapatite (HA) from physiological solutions. In this study TiO2 layers were formed by chemical vapor deposition at different substrate temperatures in order to controllably change their structure from amorphous to consisting of preferentially oriented anatase crystallites. To evaluate the influence of phase composition and surface morphology of the deposited layers on their ability to form HA titania samples were immersed in Dulbecco's phosphate‐buffered saline (DPBS). The obtained results showed that structure of TiO2 layers determines the structure of HA formed on their surface. Polycrystalline titania layers with random orientation of anatase crystallites are the most favorable for intensive nucleation and formation of continuous HA coatings in DPBS solution. The textured TiO2 layers with smooth surface enhanced formation of HA deposits which consisted of sparsely distributed large separate grains. On the basis of the experimental results it was proposed that formation of hydroxylapatite nuclei on the surface of titania layers occurs by a mechanism of epitaxial growth. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Desorption atmospheric pressure photoionization high‐resolution mass spectrometry: a complementary approach for the chemical analysis of atmospheric aerosols
Authors: Parshintsev Jevgeni , Vaikkinen Anu , Lipponen Katriina , Vrkoslav Vladimir , Cvačka Josef , Kostiainen Risto , Kotiaho Tapio , Hartonen Kari , Riekkola Marja‐Liisa , Kauppila Tiina J. 
Published: May 2015

RationaleOn‐line chemical characterization methods of atmospheric aerosols are essential to increase our understanding of physicochemical processes in the atmosphere, and to study biosphere‐atmosphere interactions. Several techniques, including aerosol mass spectrometry, are nowadays available, but they all suffer from some disadvantages. In this research, desorption atmospheric pressure photoionization high‐resolution (Orbitrap) mass spectrometry (DAPPI‐HRMS) is introduced as a complementary technique for the fast analysis of aerosol chemical composition without the need for sample preparation.MethodsAtmospheric aerosols from city air were collected on a filter, desorbed in a DAPPI source with a hot stream of toluene and nitrogen, and ionized using a vacuum ultraviolet lamp at atmospheric pressure. To study the applicability of the technique for ambient aerosol analysis, several samples were collected onto filters and analyzed, with the focus being on selected organic acids. To compare the DAPPI‐HRMS data with results obtained by an established method, each filter sample was divided into two equal parts, and the second half of the filter was extracted and analyzed by liquid chromatography/mass spectrometry (LC/MS).ResultsThe DAPPI results agreed with the measured aerosol particle number. In addition to the targeted acids, the LC/MS and DAPPI‐HRMS methods were found to detect different compounds, thus providing complementary information about the aerosol samples.ConclusionsDAPPI‐HRMS showed several important oxidation products of terpenes, and numerous compounds were tentatively identified. Thanks to the soft ionization, high mass resolution, fast analysis, simplicity and on‐line applicability, the proposed methodology has high potential in the field of atmospheric research. Copyright © 2015 John Wiley & Sons, Ltd.
Smart gateway diversity techniques and transport‐layer issues for future satellite networks
Authors: Giambene Giovanni , Luong Doanh Kim , Le Van Anh , de Cola Tomaso 
Published: May 2015

SummaryNext‐generation satellite networks will build on smart gateway diversity (SGD) architectures based on the large capacity offered by high‐frequency bands (Q, V, and W) in order to achieve very high system availability figures (greater than 99%). Despite the numerous studies about system design, little literature has explored the networking problems arising when switching traffic flows from one gateway, subject to feeder link outage, to an alternate one. In this regard, particularly promising multi‐path strategies are represented by multi‐path transmission control protocol (MP‐TCP) and concurrent multipath transfer‐stream control transmission protocol, which are the main aim of this paper along with the management of quality of service (QoS) requirements. This work shows the attractive advantages offered by MP‐TCP in various operative SGD scenarios and also explores how multi‐path strategies can be efficiently combined with QoS‐based scheduling strategies. Copyright © 2015 John Wiley & Sons, Ltd.
SRY and OCT4 Are Required for the Acquisition of Cancer Stem Cell-Like Properties and Are Potential Differentiation Therapy Targets
Authors: Murakami Shigekazu , Ninomiya Wataru , Sakamoto Erina , Shibata Tatsuhiro , Akiyama Hirotada , Tashiro Fumio 
Published: May 2015

Abstract
The acquisition of stemness is a hallmark of aggressive human hepatocellular carcinoma (hHCC). The stem cell marker OCT4 is frequently expressed in HCCs, and its expression correlates with those of putative cancer stem cell (CSC) markers and CSC properties. Here, we describe a novel mechanism of CSC maintenance by SRY through OCT4. We previously reported that Sry is involved in tumor malignancy in rodent HCCs. However, the oncogenic function of SRY in hHCCs is poorly understood. Ectopic expression of SRY increased multiple stem cell factors, including OCT4 and CD13. The OCT4 promoter contained SRY-binding sites that were directly activated by SRY. In HCC-derived cells, SRY knockdown decreased OCT4 expression and cancer stem-like phenotypes such as self-renewal, chemoresistance, and tumorigenicity. Conversely, OCT4 and SRY overexpression promoted cancer stem-like phenotypes. OCT4 knockdown in SRY clones downregulated the self-renewal capacity and chemoresistance. These data suggest that SRY is involved in the maintenance of cancer stem-like characteristics through OCT4. Moreover, CSCs of HCC-derived cells differentiated into Tuj1-positive neuron-like cells by retinoic acid. Noteworthily, SRY was highly expressed in some hHCC patients. Taken together, our findings imply a novel therapeutic strategy against CSCs of hHCCs. Stem Cells 2015;33:2652–2663
CD49f Acts as an Inflammation Sensor to Regulate Differentiation, Adhesion, and Migration of Human Mesenchymal Stem Cells
Authors: Yang Zhigang , Dong Ping , Fu Xin , Li Qiuchen , Ma Shize , Wu Dongying , Kang Ning , Liu Xia , Yan Li , Xiao Ran 
Published: May 2015

Abstract
The advent of mesenchymal stem cell (MSC)-based therapies has been an exciting innovation for the treatment of degenerative and inflammatory diseases. However, the surface markers that accurately reflect the self-renewal and differentiation potential of MSCs and their sensitivity to environmental cues remain poorly defined. Here, we studied the role of CD49f in bone marrow MSCs (BMSCs) and the mechanism by which it regulates the behavior of BMSCs under inflammatory conditions. We found that CD49f is preferentially expressed in fetal cells rather than adult cells, CD49f-positive BMSCs possess higher CFU-F formation ability and differentiation potential than CD49f negative cells, and the CD49f expression of BMSCs gradually decreases during in vitro passaging. CD49f knockdown dramatically decreased the differentiation of BMSCs and isoform A was demonstrated to be the main functional form that enhanced the differentiation ability of BMSCs. The influences of inflammatory cytokines on BMSCs revealed that TNF-α downregulated CD49f in BMSCs with impaired differentiation, decreased adhesion to laminins, and increased migration. Moreover, tissue transglutaminase was found to work together with CD49f to regulate the behavior of BMSCs. Finally, we showed that mTOR signaling rather than NF-κB activation mediated CD49f downregulation induced by TNF-α and maintained CD49f homeostasis in BMSCs. Our findings suggest that CD49f is a stemness marker of BMSCs and is tightly correlated with the behavioral changes of BMSCs under inflammatory conditions. These data demonstrate a novel role for CD49f in sensing inflammation through mTOR pathway to further modulate the behavior of MSCs to fulfill the requirements of the body. Stem Cells 2015;33:2798—2810
Group vertical handoff management in heterogeneous networks
Authors: Walid Abdellaziz , Kobbane Abdellatif , Mabrouk Abdelfettah , Sabir Essaid , Taleb Tarik , El Koutbi Mohammed 
Published: May 2015

AbstractTraditional vertical handover schemes postulate that vertical handovers (VHOs) of users come on an individual basis. This enables users to know previously the decision already made by other users, and then the choice will be accordingly made. However, in case of group mobility, almost all VHO decisions of all users, in a given group (e.g., passengers on board a bus or a train equipped with smart phones or laptops), will be made at the same time. This concept is called group vertical handover (GVHO). When all VHO decisions of a large number of users are made at the same time, the system performance may degrade and network congestion may occur. In this paper, we propose two fully decentralized algorithms for network access selection, and that is based on the concept of congestion game to resolve the problem of network congestion in group mobility scenarios. Two learning algorithms, dubbed Sastry Algorithm and Q‐Learning Algorithm, are envisioned. Each one of these algorithms helps mobile users in a group to reach the nash equilibrium in a stochastic environment. The nash equilibrium represents a fair and efficient solution according to which each mobile user is connected to a single network and has no intention to change his decision to improve his throughput. This shall help resolve the problem of network congestion caused by GVHO. Simulation results validate the proposed algorithms and show their efficiency in achieving convergence, even at a slower pace. To achieve fast convergence, we also propose a heuristic method inspired from simulated annealing and incorporated in a hybrid learning algorithm to speed up convergence time and maintain efficient solutions. The simulation results also show the adaptability of our hybrid algorithm with decreasing step size‐simulated annealing (DSS‐SA) for high mobility group scenario. Copyright © 2015 John Wiley & Sons, Ltd.
Construction and evaluation of nitric oxide generating vascular graft material loaded with organoselenium catalyst via layer-by-layer self-assembly
Authors: An Jun , Chen SiYuan , Gao JingChen , Zhang Xu , Wang YuanYuan , Li YanDong , Mikhalovsky Sergey , Kong DeLing , Wang ShuFang 
Published: May 2015

Abstract
A new biomimetic material for artificial blood vessel with in situ catalytic generation of nitric oxide (NO) was prepared in this study. Organoselenium immobilized polyethyleneimine as NO donor catalyst and sodium alginate were alternately loaded onto the surface of electrospun polycaprolactone matrix via electrostatic layer-by-layer self-assembly. This material revealed significant NO generation when contacting NO donor S-nitrosoglutathione (GSNO). Adhesion and spreading of smooth muscle cells were inhibited on this material in the presence of GSNO, while proliferation of endothelial cells was promoted. In vitro platelet adhesion and arteriovenous shunt experiments demonstrated good antithrombotic properties of this material, with inhibited platelet activation and aggregation, and prevention of acute thrombosis. This study may provide a new method of improving cellular function and antithrombotic property of vascular grafts.