bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Regioselective Synthesis of Multisubstituted Furans via Metalloradical Cyclization of Alkynes with α‐Diazocarbonyls: Construction of Functionalized α‐Oligofurans.
Authors: Cui Xin , Xu Xue , Wojtas Lukasz , Kim Martin M. , Zhang X. Peter 
Published: May 2013

AbstractThis method tolerates a broad variety of functional groups and gives access to multisubstituted furans with diverse functionalities.
ChemInform Abstract: Reaction of (Z)‐5‐(Bromomethylene)thiophen‐2(5H)‐one with Some Nucleophiles in Search for New Biofilm Inhibitors.
Authors: Benneche Tore , Chamgordani Elahe Jafari , Scheie Anne Aamdal 
Published: May 2013

AbstractThe nucleophilic substitution of the bromo substituent in title compound (I) is studied.
ChemInform Abstract: Synthesis of N‐Acetyl‐3,3a,4,8b‐ and ‐1,3a,4,8b‐tetrahydrocyclopenta[b]indoles from N‐ and 2‐(Cyclopent‐2‐en‐1‐yl)anilines.
Authors: Skladchikov D. A. , Buranbaeva R. S. , Fatykhov A. A. , Ivanov S. P. , Gataullin R. R. 
Published: May 2013

AbstractN‐Acylation of anilines (I) leads to the formation of a diastereoisomeric mixture of atropisomers (III) which is separable at room temperature for (IIIb).
ChemInform Abstract: 2‐Hydroxyethylammonium Acetate as a Reusable and Cost‐Effective Ionic Liquid for the Efficient Synthesis of Bis(pyrazolyl)methanes (III) and 2‐Pyrazolyl‐1‐nitroalkanes (V).
Authors: Sobhani Sara , Nasseri Razieh , Honarmand Moones 
Published: May 2013

AbstractTitle compounds (III) are prepared by one‐pot tandem Knoevenagel—Michael reaction of pyrazolone (I) with various aldehydes (II) in the presence of hydroxyethylammonium acetate as a task‐specific ionic liquid.
ChemInform Abstract: Synthesis of 3‐(1‐Methyl‐1H‐imidazol‐2‐ylthio)propanoic Acid and (E)‐3‐(1‐Methyl‐1H‐imidazol‐2‐ylthio)acrylic Acid.
Authors: Hattan Christopher M. , Shojaie Jalil , Lau Serrine S. , Anders M. W. 
Published: May 2013

AbstractThe E/Z ratio of the reaction products of (I) with methyl or tert‐butyl propiolate (II) or (V) is studied (only some yields are given).
ChemInform Abstract: Fragment‐Based Discovery of Novel and Selective mPGES‐1 Inhibitors. Part 1. Identification of Sulfonamido‐1,2,3‐triazole‐4,5‐dicarboxylic Acid.
Authors: Lee Kijae , Pham Van Chung , Choi Min Ji , Kim Kyung Ju , Lee Kyung‐Tae , Han Seong‐Gu , Yu Yeon Gyu , Lee Jae Yeol 
Published: May 2013

AbstractSulfonamido‐1,2,3‐triazole‐4,5‐dicarboxylic acid derivatives (III) and (V) are synthesized using an azide—alkyne click reaction procedure.
ChemInform Abstract: Synthesis of New Triazole Acetamides with Inotropic Effects.
Authors: Wu Yan , Ma Long‐Xu , Sun Liang‐Peng , Song Ming‐Xia , Cui Xun , Piao Hu‐Ri 
Published: May 2013

AbstractA series of new triazole acetamides (III) is synthesized and screened for their positive inotropic activity.
ChemInform Abstract: Highly Efficient Synthesis of 4‐Trialkylsilyl(germyl)‐1H‐1,2,3‐triazole‐5‐carbaldehydes
Authors: Demina M. M. , Nguyen T. L. H. , Shaglaeva N. S. , Mareev A. V. , Medvedeva A. S. 
Published: May 2013

Abstractin aqueous medium without any catalyst
ChemInform Abstract: Regioselective Synthesis of 2‐Amino‐Substituted 1,3,4‐Oxadiazole and 1,3,4‐Thiadiazole Derivatives via Reagent‐Based Cyclization of Thiosemicarbazide Intermediate.
Authors: Yang Seung‐Ju , Lee Seok‐Hyeong , Kwak Hyun‐Jung , Gong Young‐Dae 
Published: May 2013

Abstract2‐Amino‐substituted 1,3,4‐oxadiazole (II) and 1,3,4‐thiadiazole derivatives (V) are prepared from the same thiosemicarbazides (I) depending on the reagents used (EDC or TosCl/NEt3).
ChemInform Abstract: Catalytic Highly Enantioselective Vinylogous Povarov Reaction.
Authors: Caruana Lorenzo , Fochi Mariafrancesca , Ranieri Silvia , Mazzanti Andrea , Bernardi Luca 
Published: May 2013

AbstractA series of chiral tetrahydroquinolines (III) is prepared with high diastereo‐ and enantioselectivity by a hitherto not described Povarov reaction of imines (I) with acylaminobutadienes (II).
ChemInform Abstract: Synthesis and Characterization of a New Chiral Pentacyclic Phosphine.
Authors: Moussa Souad , Aloui Faouzi , Ben Hassine Bechir 
Published: May 2013

AbstractThe helically chiral pentacyclic phosphine (IX) containing a thiophene ring is obtained in a five‐step sequence via a Wittig reaction, a palladium‐catalyzed Mizoroki—Heck coupling, and classical oxidative photocyclization reactions.
ChemInform Abstract: Facile Synthesis of (Z,E)‐9,11‐Hexadecadienal, the Major Sex Pheromone Component of the Sugarcane Borer Diatraea Saccharalis: An Efficient Strategy for Synthesis of (Z,E)‐Dienic Pheromones.
Authors: Tao Yunhai , Yang Xiaomei , Jin Yi , Wang Qingzhong 
Published: May 2013

AbstractThe efficient and stereoselective synthesis of title compound (I) consists of a seven step procedure starting from 7‐bromo‐(Z,E)‐4,6‐heptadienal and is achieved in 38% overall yield.
The Distorted Tropane of Scopoline
Authors: Écija Patricia , Cocinero Emilio J. , Lesarri Alberto , Basterretxea Francisco J. , Fernández José A. , Castaño Fernando 
Published: May 2013

AbstractThe structural isomerization of scopine into scopoline (oscine) has been observed in a supersonic jet expansion using microwave spectroscopy. The rotational spectrum evidences a single structure in the gas phase, providing a first description of the (three‐ring) structurally distorted tropane in scopoline. The absence of rotational signatures of any scopine conformation suggests a practically quantitative isomerization at the vaporization temperatures of the experiment (ca. 90 °C). The determined rotational parameters of scopoline reveal the structural consequences of the intramolecular cyclation of scopine, which breaks the original epoxy group and creates a new ether bridge and a 7β‐hydroxytropane configuration. The hydroxy group further stabilizes the molecule by an OH⋅⋅⋅N intramolecular hydrogen bond, which, in turn, forces the N‐methyl group to the less stable axial form. Supporting ab initio (MP2) and DFT (B3LYP, M06‐2X) calculations are included.
New Insights into the Oxygen Reduction Reaction Mechanism on Pt (111): A Detailed Electrochemical Study
Authors: Gómez‐Marín Ana M. , Feliu Juan M. 
Published: May 2013

AbstractThe oxygen reduction reaction (ORR) is undoubtedly the most important fuel‐cell cathodic reaction. In this work, a detailed electrochemical analysis of the ORR on Pt (111) in nonadsorbing electrolytes was performed, which included the high‐potential region Eup=1.15 V while ensuring the electrode surface structure stability. Our results suggest that the reduction of a soluble intermediate species formed during the ORR is the rate‐determining step in the whole reaction mechanism. This species does not undergo any other electrochemical reaction at E>0.9 V and may accumulate close to the electrode surface. Together with dissolved O2, this intermediate may modify the oxide‐growth dynamics on Pt (111). Hence, both species interact with the electrode surface through complex catalytic networks. Under certain experimental conditions, oxygenated species from the oxidation of Pt (111) may enhance the overall ORR current. These results propose an alternative to explain the current state of the art for this fundamental process.
Cytomorphologic overlap of differentiated thyroid carcinoma and lung adenocarcinoma and diagnostic value of TTF‐1 and TGB on cytologic material
Authors: Sathiyamoorthy Srividya , Maleki Zahra 
Published: May 2013

Thyroid carcinomas and lung adenocarcinoma share cytomorphological features yet have different prognoses. Thyroid Transcription Factor‐1 (TTF‐1) is an immunohistochemical (IHC) marker used to confirm pulmonary and thyroid carcinoma, while Thyroglobulin (TGB) is expressed by thyroid carcinoma. The cytopathology archive of The Johns Hopkins Hospital was searched for cases of lung adenocarcinoma versus thyroid carcinoma with TTF‐1 and TGB IHC. Forty‐four cases of lung adenocarcinoma (25) and thyroid carcinoma (19) were retrieved. One was metastatic lung adenocarcinoma to the thyroid and three were metastatic papillary thyroid carcinoma (PTC) to the lung. The initial interpretation of two cases from bony lesions was metastatic lung adenocarcinoma. In light of additional clinical information and TGB immunostain, the diagnoses of these two cases changed to metastatic thyroid carcinoma. TTF‐1 and TGB is a small immunostain panel that can differentiate lung adenocarcinoma from thyroid carcinoma and prevent misdiagnosis and its consequences. Diagn. Cytopathol. 2014;42:5–10. © 2013 Wiley Periodicals, Inc.
Belowground interactions shift the relative importance of direct and indirect genetic effects
Authors: Genung Mark A. , Bailey Joseph K. , Schweitzer Jennifer A. 
Published: May 2013

AbstractIntraspecific genetic variation can affect decomposition, nutrient cycling, and interactions between plants and their associated belowground communities. However, the effects of genetic variation on ecosystems can also be indirect, meaning that genes in a focal plant may affect ecosystems by altering the phenotype of interacting (i.e., neighboring) individuals. We manipulated genotype identity, species identity, and the possibility of belowground interactions between neighboring Solidago plants. We hypothesized that, because our plants were nitrogen (N) limited, the most important interactions between focal and neighbor plants would occur belowground. More specifically, we hypothesized that the genotypic identity of a plant's neighbor would have a larger effect on belowground biomass than on aboveground biomass, but only when neighboring plants were allowed to interact belowground. We detected species‐ and genotype‐level variation for aboveground biomass and ramet production. We also found that belowground biomass and ramet production depended on the interaction of neighbor genotype identity and the presence or absence of belowground interactions. Additionally, we found that interspecific indirect genetic effects (IIGEs; changes in focal plant traits due to the genotype identity of a heterospecific neighbor) had a greater effect size on belowground biomass than did focal genotype; however, this effect only held in pots that allowed belowground interactions. These results expand the types of natural processes that can be attributed to genotypes by showing that, under certain conditions, a plant's phenotype can be strongly determined by the expression of genes in its neighbor. By showing that IIGEs are dependent upon plants being able to interact belowground, our results also provide a first step for thinking about how genotype‐based, belowground interactions influence the evolutionary outcomes of plant‐neighbor interactions.
The interactive effect of an emerging infectious disease and an emerging contaminant on Woodhouse's toad (Anaxyrus woodhousii) tadpoles
Authors: Brown Jennifer R. , Miiller Tyler , Kerby Jacob L. 
Published: May 2013

Abstract

Two factors that influence amphibian population declines are infectious diseases and exposure to anthropogenic contaminants. The authors examined an emerging fungal pathogen, Batrachochytrium dendrobatidis (Bd), and its interaction with an emerging contaminant, the antimicrobial triclosan. They first conducted a 2 × 2 × 4 factorial study to examine the interactive impacts of dragonfly predator cues, Bd, and triclosan (0 µg/L, 10 µg/L, 100 µg/L, and 1000 µg/L) on Woodhouse's toad (Anaxyrus woodhousii) tadpoles. The authors measured the lethal and sublethal impacts of these stressors on tadpoles over 4 wk. All tadpoles in the 100-µg/L and 1000-µg/L concentrations of triclosan died within 24 h of exposure, but tadpoles in the low concentration (10 µg/L) survived. Tadpoles exposed to only Bd (no triclosan) exhibited a low survival rate (67.5%), whereas those exposed to both 10 µg/L triclosan and Bd exhibited a high survival rate (91.1%), implying that triclosan inhibits effects of Bd on tadpoles. Batrachochytrium dendrobatidis and predator cue exposure individually increased the developmental rate of the surviving tadpoles, but this effect was absent when these factors were combined with triclosan. In a follow-up study, the authors found Bd growth in culture was significantly inhibited at the 10-µg/L concentration of triclosan and completely inhibited at 100 µg/L. These findings suggest that interactions among multiple stressors can be complex and require examination in conjunction with one another to evaluate actual impacts to aquatic fauna. Environ Toxicol Chem 2013;32:2003–2008. © 2013 SETAC
Testing for Modes of Inheritance Involving Compound Heterozygotes
Authors: Bacanu Silviu‐Alin 
Published: May 2013

ABSTRACTFunctional variants change the protein product or the expression of genes. Due to the latest advances in sequencing technology, most known functional variants can now be assayed in a cost‐effective manner. However, to fully use the information from functional variants, researchers need to model the joint effect of these variants. In this article, we propose methods that model the action/interaction of loss‐of‐function (LOF) mutations, i.e., those mutations that eliminate the protein product of a gene. When multiple LOFs occur in the same causal gene/region, their effect on a phenotype might depend on whether these mutations lie on the same DNA strand/haplotype. When compared to LOFs occurring on the same strand, if these mutations lie on different strands, both copies of the gene are impaired and the impact on the relevant phenotypes is likely to be more severe. To use the information from LOF strand colocalization, we propose three methods that utilize the information from the estimated number of affected strands. We compare the performance of the proposed and competing methods by using simulations of common and rare LOF variants. Two of the proposed methods exhibited desirable power profiles, the first for both common and rare LOFs and the second only for common LOFs. One of the existing methods, collapsed double heterozygosity, exhibits good power to detect compound models for rare variants, especially when no haplotype harbors two or more rare alleles. Consequently, we recommend these three methods to be used for the analysis of functional variants coming from sequencing studies.
Observations of core‐mantle boundary Stoneley modes
Authors: Koelemeijer Paula , Deuss Arwen , Ritsema Jeroen 
Published: May 2013

AbstractCore‐mantle boundary (CMB) Stoneley modes represent a unique class of normal modes with extremely strong sensitivity to wave speed and density variations in the D” region. We measure splitting functions of eight CMB Stoneley modes using modal spectra from 93 events with Mw> 7.4 between 1976 and 2011. The obtained splitting function maps correlate well with the predicted splitting calculated for S20RTS+Crust5.1 structure and the distribution of Sdiff and Pdiff travel time anomalies, suggesting that they are robust. We illustrate how our new CMB Stoneley mode splitting functions can be used to estimate density variations in the Earth's lowermost mantle.
Is the trend in TEJ reversing over the Indian subcontinent?
Authors: Venkat Ratnam M. , Krishna Murthy B. V. , Jayaraman A. 
Published: May 2013

AbstractIndian Summer Monsoon (ISM) is mainly characterized by seasonal wind reversal in low level jet stream and tropical easterly jet (TEJ) among several other elements of monsoon systems. TEJ is observed in general between 100 and 150 hPa during June–September over the Indian region and its strength is directly related to the monsoon rainfall. In the context of changing climate, large reduction in its extent and weakening of its strength were reported. Using high resolution measurements, we report here the observation of a sharp strengthening of the TEJ during the recent warmest decade (2001–2010), reaching its 1970s value. We also show that this change is reflected in the tropical cyclone systems and finally on the precipitation patterns over the Indian region as they are interlinked. We attribute this unusual change partly to the change in the circulation due to the tropospheric warming and lower stratospheric ozone recovery.
Variability of central United States April–May tornado day likelihood by phase of the Madden‐Julian Oscillation
Authors: Barrett Bradford S. , Gensini Victor A. 
Published: May 2013

AbstractApril–May tornado day likelihood from 1990 to 2011 was calculated for the central United States for phases of the Madden‐Julian Oscillation (MJO). An April tornado day was found more likely during MJO phases 6 and 8 and less likely during phases 3, 4, and 7. A May tornado day was found more likely during phases 5 and 8 and less likely in phases 2 and 3. During phases with above‐normal tornado day likelihoods, positive anomalies of convective available potential energy, bulk vertical wind shear, and storm‐relative helicity were found in the central United States. Negative anomalies were found during phases with below‐normal tornado day likelihoods. Anomalies of such environmental parameters were connected to the MJO via variability in tropospheric circulation. These results provide an important starting point for extended range prediction of U.S. tornado activity.
Prospective associations between benzodiazepine use and later life satisfaction, somatic pain and psychological health among the elderly
Authors: Nordfjærn Trond 
Published: May 2013

ObjectiveThis study aimed to investigate prospective associations between benzodiazepine use and later life satisfaction, sleep difficulties, perceived general health, anxiety symptoms and somatic pain among the elderly.MethodsA 13‐year prospective cohort study was conducted in a Norwegian population‐based sample of 15 830 elderly individuals. Baseline control measures of the investigated psychological constructs and a wide range of demographic and health‐relevant covariates were obtained from the Nord‐Trøndelag Health Study (HUNT 2, 1995–1997). Follow‐up data were obtained from the third wave (HUNT 3, 2006–2008) of the same epidemiological study. The Norwegian Prescription Database (2004–2008) was used to link pharmacy prescription records of benzodiazepines for each case to the HUNT 2 and HUNT 3 materials.ResultsUse of benzodiazepines was associated with less life satisfaction and more sleep difficulties at follow‐up. These tendencies increased by more frequent patterns of use. Benzodiazepine use had relatively weak relations to perceived general health, but intermittent and chronic use was related to higher anxiety symptoms at follow‐up. Such patterns were also modestly related to somatic pain at follow‐up.Discussion and conclusionBenzodiazepines should be dispensed at a high‐threshold policy among the elderly. By developing clear‐cut discontinuation plans, clinicians could avoid chronic use and focus on psychosocial treatment for psychological disorders. Copyright © 2013 John Wiley & Sons, Ltd.
Proposal for a “Harmonized” strategy for the assessment of the HP 14 property
Authors: Pandard Pascal , Römbke Jörg 
Published: May 2013

Abstract
In Europe, the decision whether waste is hazardous or not is based on 15 properties, among them the HP 14 property (“ecotoxic”: waste that presents or may present immediate or delayed risks for 1 or more sectors of the environment). This document describes a strategy for assessing the HP 14 property, based on a combination of 2 approaches: the summation of classified compounds in the waste carried out according to the regulation on Classification, Labeling and Packaging (CLP) of substances and mixtures and the usage of the results of biotests performed on waste eluates and solid wastes. The proposal is based mainly on recommendations of a European ring test carried out in 2007, the work performed in the CEN/TC 292/WG 7 standardization working group, and the results of various research projects regarding the ecotoxicological characterization of waste carried out mainly in France and Germany. Examples are provided showing that, using this approach, a distinction between hazardous and nonhazardous wastes is possible, independent of which type of threshold values is used (currently, both effect concentrations [EC] or lowest ineffective dilutions [LID] values have been used successfully). Furthermore, a battery of tests (3 using waste eluates and 3 using solid waste samples, plus, under certain conditions, a genotoxicity test) is recommended for the ecotoxicological testing of wastes. We propose to consider this combined approach when defining the legal requirements for the ecotoxicological classification of wastes. Integr Environ Assess Manag 2013;9:665–672. © 2013 SETAC
Do invasive populations of topmouth gudgeon (Pseudorasbora parva, Temminck and Schlegel) from disturbed and undisturbed habitats follow different life‐histories?
Authors: Záhorská Eva , Švolíková Kristína , Kováč Vladimír 
Published: May 2013

AbstractLife‐histories of organisms are closely associated with their ontogenetic trajectories that result from an interplay between genes and environment. Ontogeny supplies the organisms with a potential to generate a variety of phenotypes, an emergent property that is essential for species to survive in various environments and/or to establish self‐sustaining populations in novel environments. Topmouth gudgeon (Pseudorasbora parva) is one of the most invasive species in Europe. Life‐history traits of three populations of topmouth gudgeon from habitats exposed to disturbances of different intensity were analysed in this study. The main aim was to execute the first statistical test of the hypothesis of alternative ontogenies and invasive potential. To test this hypothesis, quantitative life‐history traits, such as absolute and relative fecundity, size of oocytes, size at maturation, and annual gonadosomatic index variation in the three populations of topmouth gudgeon were examined and evaluated statistically. Two of three quantitative parameters of life‐history traits support the hypothesis, whereas the third one remains equivocal but not enough to falsify it.
Writing in the Wild: Writers’ Motivation in Fan‐Based Affinity Spaces
Authors: Curwood Jen Scott , Magnifico Alecia Marie , Lammers Jayne C. 
Published: May 2013

AbstractIn order to understand the culture of the physical, virtual, and blended spheres that adolescents inhabit, we build on Gee's concept of affinity spaces. Drawing on our ethnographic research of adolescent literacies related to The Hunger Games novels, the Neopets online game, and The Sims videogames, this article explores the nature of interest‐driven writing in these spaces. We argue that fan‐based affinity spaces motivate young adults to write because they offer multiple modes of representation, diverse pathways to participation, and an authentic audience. As scholars and educators, we posit that these out‐of‐school spaces can offer youth new purposes, modes, and tools for their written work.
Critical Literacy and the Ethical Responsibilities of Student Media Production
Authors: Parker Jessica K. 
Published: May 2013

AbstractToday's complex literate environments require contemporary authors to focus on the ethical responsibilities of media creation. This study highlights 12th graders in California who produced a documentary on Latino immigration and chronicles the complex interactions between student‐generated media, critical literacy, and ethics. Findings highlight two interrelated ethical tensions related to the filmmaker–subject relationship: the intertwined issues related to reciprocity and relations of power and the personal and political representation of Latino immigration to the United States. An essential component of critical literacy is for students to develop meta‐awareness of the choices they make within media production: to reflect on one's choices and the potential impact of these choices on others. Educators should recognize the ethical responsibilities of media making such as students’ interpersonal relationships and potential sociopolitical issues of representation.