bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress Coping Framework As an Effort To Improve Quality of Life Patients with Chronic Obstructive Pulmonary Disease: A Literature Review
Authors: Sutrisno Sutrisno , Rondhianto Rondhianto , Susanto Tantut 
Published: July 2024

ABSTRACT COPD patients usually experience a decrease in quality of life due to COPD symptoms such as coughing, shortness of breath,exacerbationAcute disease and comorbidities that occur in COPD patients cause limitations in daily activities. Stress coping is one of the factors that causes good or bad self-care behavior in COPD patients. To describe the influence, stress coping and level of selfcare in COPD patients on their quality of life. The method of this study is a literature review. Literature searches using electronic databases such as PubMed, Google Scholar and Science Direct. A literature review was carried out on international journals published in the last 5 years, available in full text. The keywords used were "self-care", stress coping" and "quality of life" for COPD patients. The selection of articles followed the PRISMA approach. This review summarizes eighteen articles. Five articles discussed self-care, the SelfEfficacy scale, and discriminative validity with higher self-care scale scores in individuals with greater COPD severity and poorer health status. Five articles discuss coping stress in COPD sufferers. COPD patients who have good knowledge will have more coping mechanism strategies so that their quality of life becomes more prosperous. Seven articles discussed the quality of life of COPD sufferers. If a COPD patient has good stress coping and strong confidence and confidence in his or her abilities, this will influence self-care actions and improve the COPD patient's quality of life. Future researchers are encouraged to explore similar research themes using other journal search engines to enrich the study. Keywords: Self Care, Stress Coping, Quality Of Life, COPD
Relationship Between Level of Maternal Knowledge about Nutrition of Pregnant Women with the Incidence of Stunting in Children Under Five
Authors: Johan Erik , Firdaus Achmad Dafir , Febriani Reny Tri , Trigantara Regista 
Published: July 2024

ABSTRACT Stunting can be caused by several factors, including poor nutritional intake during pregnancy in toddlers. Some of them are readiness to become mothers where this is motivated by a very high rate of early marriage. Unpreparedness in facing motherhood can affect perceptions in parenting. This study aims to determine the relationship between the level of maternal knowledge about nutrition of pregnant women with the incidence of stunting in children under five in Sisir Village, Batu City with a cross-sectional analytical descriptive design involving 56 respondents consisting of maternal respondents and toddlers aged 1-5 years with purposive sampling techniques. Data were collected with maternal knowledge level questionnaires during pregnancy and z score graphs. Results: Data analysis using Spearman Rank test with α = 0.05. The results showed that the significance value (sig) or p value was 0.009. Because the value of sig (0.009) > (0.05) with a correlation value of 0.347, the results of the data obtained from respondents mean h0 rejected h1 accepted. There is a relationship between the level of knowledge of parents and the incidence of stunting in toddlers. The results of the study concluded that there is a significant relationship between the level of knowledge of parents and the incidence of stunting in toddlers. Discussion: In Batu city comb sub-district. It is hoped that mothers can try to find knowledge and information related to nutrition and other factors that can cause stunting, and mothers can start paying attention to nutrition during pregnancy for preventive measures against the impact of stunting on the development of the next child at birth. Keywords: Maternal Knowledge, Gestation Period, Incidence Of Stunting
Clinical, Microbiological Profile and Antibiotics Use in Admitted Patients of Urinary Tract Infection
Authors: Singh Harpreet , Suri Vikas , Mohan Balvinder , Mohindra Ritin , Taneja Neelam , Bhalla Ashish 
Published: July 2024

Urinary tract infections (UTI) can vary from simple cystitis to pyelonephritis with severe sepsis. The objective of this study is to provide information about the clinical and microbiological profile of admitted patients of urinary tract infection, patterns of organisms isolated, antibiotic sensitivity pattern and antibiotics use. It was a prospective observational study conducted on 40 patients age >14 years admitted with diagnosis of UTI based on clinical and microbiological criteria over 8 months at a tertiary care hospital in North India. Data was collected for the clinical, microbiological profile, empirical and definite antibiotics use with duration of stay and outcome of patients. Among 40 cases of UTI; male to female ratio was 1:1 with mean age of 51.3± 16.32 years. Fever was present in almost all (97.5%) of the patients and three-fourth (75%) of them had dysuria. Type-2 Diabetes Mellitus was most common (55%) underlying condition and mean HbA1c was 9.37±2.27 followed by obstructive uropathy (17.50%). Most of cases (82.5%) were of complicated UTI; where Pyelonephritis was 42%, Emphysematous Pyelonephritis 12.5% and Renal Abscess 7.5%. Most common (37.5%) organism isolated from urine/ pus culture was Escherichia coli. More than half of the patients (55%) were given empirical antibiotics injection piperacillin tazobactam and carbapenems was used in more than one third (35%) of patients. The mean duration of antibiotics use was 14.55±4.94 days. Two (5.0%) patients expired out during the study period. Uncontrolled Diabetes Mellitus remains the major underlying condition in cases of complicated UTI. E coli is the most common organism isolated from urine/ pus culture. Most of the patients had favourable outcome with guided antibiotics and interventions.
Bangladesh Med J. 2023 May; 52(2): 15-19
TELEHEALTH SEBAGAI UPAYA PENINGKATAN KEPUASAN PASIEN DALAM MEMANFAATKAN PELAYANAN KESEHATAN : META ANALISIS
Authors: Kurniawan Hendra Dwi 
Published: July 2024

Latar Belakang : Kepuasan pasien merupakan salah satu hal yang perlu diperhatikan oleh seluruh penyedia pelayanan kesehatan. Dengan tingkat kepuasan yang tinggi diharapkan dapat meningkatkan kepercayaan masyarakat dalam bidang pelayanan kesehatan, sehingga masyarakat tidak ragu dalam memanfaatkannya. Era digitalisasi memberikan dampak yang luas pada bidang kesehatan salah satunya adalah munculnya fasilitas layanan telehealth. Banyak penyedia pelayanan kesehatan yang sudah menerapkan fasilitas layanan telehealth untuk memberikan pelayanan kesehatan yang dibutuhkan oleh pasien. Adanya layanan telehealth, diharapkan dapat membantu kebutuhan pasien dalam pemanfaatan pelayanan kesehatan yang dibutuhkannya, sehingga tingkat kesehatan masyarakat dapat meningkat. Tujuan : untuk menganalisis keefektifan layanan telehealth terhadap peningkatan kepuasan pasien dalam memanfaatkan pelayanan kesehatan. Metode : Penelitian ini merupakan penelitian meta analisis dan systematic review dengan PICO (Population = pasien yang menggunakan telehealth, Intervention = telehealth, Comparison = tanpa menggunakan telehealth, Outcome = kepuasan pasien). Artikel yang digunakan dalam penelitian ini diperoleh dari beberapa database diantaranya yaitu PubMed, Springer Link, ScienceDirect, dan Google Scholar. Artikel yang digunakan adalah artikel full-text dari tahun 2019 hingga 2024. Artikel dipilih menggunakan diagram PRISMA flow. Artikel dianalisis menggunakan aplikasi RevMan 5.3. Hasil : Sebanyak 7 artikel yang dianalisis yang diulas dalam studi meta analisis ini berasal dari Amerika, Ethiopia, Iran, dan Kanada. Studi menunjukkan bahwa layanan telehealth dapat meningkatkan kepuasan pasien dalam memanfaatkan pelayanan kesehatan (aOR 1.51; CI 95% = 1.07 hingga 1.24; p = 0.01). Kesimpulan : Pasien yang menggunakan layanan telehealth dalam memanfaatkan fasilitas pelayanan kesehatan dapat meningkatkan kepuasan pasien sebanyak 1.51 kali dibandingkan pasien yang tidak menggunakan telehealth.

Kata Kunci:
Kepuasan pasien, pelayanan kesehatan, telehealth
Non-integrin laminin receptor (LamR) plays a role in axonal outgrowth from chicken DRG via modulating the Akt and Erk signaling
Authors: Mrówczyńska Ewa , Machalica Karolina , Mazur Antonina Joanna 
Published: July 2024

37/67 kDa laminin receptor (LamR)/ribosomal protein SA exhibits dual function as both a ribosomal protein and cell surface receptor for laminin. LamR influences critical cellular processes such as invasion, adhesion, and migration when acting as a receptor. Despite the acknowledged importance of LamR/67LR in various cellular processes, its contribution to the peripheral nervous system development is obscure. Thus, this study investigated the biological activity of LamR in peripheral axonal outgrowth in the presence of laminin-1 or Ile-Lys-Val-Ala-Val (IKVAV) peptide, whose important role in dorsal root ganglia (DRG) axonal outgrowth we recently showed. Unexpectedly, we did not observe LamR on the surface of DRG cells or in a conditioned medium, suggesting its intracellular action in the negative regulation of DRG axonal outgrowth. Using C-terminus LamR-targeting IgG, we demonstrated the role of LamR in that process, which is independent of the presence of Schwann cell precursors (SCPs) and is mediated by extracellular signal-regulated kinase (Erk) and Protein kinase B (Akt1/2/3) signaling pathways. Additionally, we show that the action of LamR towards laminin-1-dependent axonal outgrowth is unmasked only when the activity of integrin β1 is perturbed. We believe that modulation of LamR activity provides the basis for its use for inhibiting axon growth as a potential therapeutic agent for regulating abnormal or excessive neurite growth during neurodevelopmental diseases or pathological nerve regeneration.
Reading stories in Arabic: the impact of lexico-phonological and diglossic distance level on comprehension and receptive and productive vocabulary among Arab kindergarten children
Authors: Shahbari-Kassem Abeer , Asli-Badarneh Abeer , Hende Nareman , Roby-Bayaa Amal 
Published: July 2024

PurposeThis study aims to investigate the impact of the lexico-phonological diglossic distance of story reading (a scaffolded storybook intervention, informed by Vygotsky’s theory of scaffolding and fading) on Arabic-speaking preschool children’s comprehension and receptive and productive vocabulary.MethodThe participants were 139 Israeli-Palestinian kindergartners: 71 composed an intervention group and 68 composed a comparison group. The intervention group heard stories gradually from the SpA, identical, cognate, and unique word forms, whereas the comparison group heard traditional stories unrelated to their lexico-phonological distances. Story 1 was read in unique spoken Arabic (SpA) form, stories 2 and 3 were read in 58 and 45% identical and cognate word forms, respectively, and story 4 was read in 70% unique word forms.ResultsThe results clearly showed that children’s vocabulary and story understanding was significantly higher after the intervention, especially noticeable in stories that contained a higher proportion of Standard Arabic (StA). Interestingly, the stories told entirely in Spoken Arabic (SpA) were the most effective, yielding the highest scores in both comprehension and vocabulary. Stories that mixed different word forms also performed well, though not as strongly as the SpA stories, while those solely in StA were the least effective.ConclusionThe findings of the study suggest that scaffolded storybook intervention may enhance the receptive vocabulary and comprehension skills of children. This study shows that, in the context of diglossia, stories should be read to children systematically and gradually according to the lexical-phonological distance of words in the stories.
Not just phonology: a longitudinal study of dyslexia subtypes based on the distinction between reading accuracy and reading rate
Authors: Jabbour-Danial Maysa , Share David L. , Shalhoub-Awwad Yasmin 
Published: July 2024

IntroductionPrevious cross-sectional investigations by Shany and colleagues have provided evidence of double dissociation among dyslexics between word reading accuracy and (pure) word reading rate. A rate-disabled subtype (with intact reading accuracy) evinced deficits only in rapid naming (RAN); An accuracy-disabled subtype (with intact reading rate) showed deficits in phonological awareness (PA) and morphological awareness (MA) but not RAN.MethodThe present longitudinal study followed 639 Palestinian Arabic-speaking children from preschool to Grade 1 with the aim of determining (1) whether a dissociation between PA C MA and RAN is apparent among pre-literate preschoolers, (2) whether the PA C MA-disabled subgroup constitutes a mild form of Developmental Language Disorder (DLD), (3) whether our three disabled subgroups (PA C MA-only, RAN-only, and PA C MA-plus-RAN) can be differentiated on preschool early literacy measures and, (4) whether the three at-risk subgroups develop into selectively rate-disabled, accuracy-disabled, or doubly-disabled (accuracy C rate) readers in Grade 1?ResultsOur findings confirmed the existence of two distinct selectively disabled/at-risk subgroups in preschool: a RAN-only subgroup with intact PA and MA and a PA C MA subgroup with broad impairments across language measures but intact RAN. Grade 1 reading data also confirmed that the RAN-disabled subgroup became slow but accurate readers, whereas the PA C MA subgroup developed into inaccurate and slow readers.DiscussionOur study indicates partial dissociation between early dyslexia subtypes, each displaying distinct and non-overlapping cognitive-linguistic profiles in preschool. The study also revealed a strong association between reading accuracy and reading rate among beginning readers. This study emphasizes the importance of considering heterogeneity in reading outcomes as well as multiple oral language skills beyond the well-documented role of PA.
Predictive value of D-dimer to albumin ratio for severe illness and mortality in patients with COVID-19
Authors: Xiao Benjie , Yang Zhangwei , Liang Huazheng , Han Yudi , Wu Yinyan , Xiao Jingjing , Bi Yong 
Published: July 2024

ObjectiveAlthough the impact of the variants of COVID-19 on the general population is diminishing, there is still a certain mortality rate for severe and critically ill patients, especially for the elderly with comorbidities. The present study investigated whether the D-dimer to albumin ratio (DAR) can predict the severity of illness and mortality in COVID-19 patients.MethodsA total of 1,993 patients with COVID-19 were retrospectively reviewed and the association of DAR with severe or critical illness or death during hospitalization was analyzed. The area under the ROC curve was used to screen the best indicators, Chi-square test, rank sum test, and univariate and multivariate binary logistic regression analysis were used to calculate the mean value of difference and adjusted odds ratio (aORs) with their 95% CI, and finally, survival was analyzed using Kaplan–Meier (KM) curves.ResultsAmong 1,993 patients with COVID-19, 13.4% were severely ill, and the mortality rate was 2.3%. The area under the curve (AUC) using DAR to predict severe and critically ill patients was higher than that using other parameters. The best cut-off value of DAR was 21 in the ROC with a sensitivity of 83.1% and a specificity of 68.7%. After adjusting age, gender, comorbidities, and treatment, the binary logistic regression analysis showed that elevated DAR was an independent risk factor for severely ill and mortality of COVID-19 patients. The KM curve suggested that patients with a higher DAR was associated with worse survival. The negative predictive value of DAR (21) for adverse prognosis and death was 95.98 and 99.84%, respectively, with a sensitivity of 80.9 and 95.65%, respectively.ConclusionThe DAR may be an important predictor for severe illness and mortality in COVID-19 patients.
Identification of novel Tet(X6)-Tet(X2) recombinant variant in Elizabethkingia meningoseptica from a bullfrog farm and downstream river in China
Authors: Jin Haobo , Jia Qing , Jin Xi , Zhu Xinlong , Wang Min-Ge , Sun Ruan-Yang , Cui Chaoyue 
Published: July 2024

IntroductionThe dissemination of strains producing tetracyclines monooxygenase Tet(X) from breeding farms to the natural environment poses a potential threat to public health.MethodsAntimicrobial susceptibility testing and WGS were performed to identify resistance phenotypes and genotypes. Cloning experiments, sequence alignment, and homology modeling were used to characterize the function and formation mechanisms of the recombinant variant. The mobilization potential of Tet(X) was assessed by collinearity analysis, conjugation experiments, and phylogenetic analysis.ResultsThree tet(X)-producing Elizabethkingia meningoseptica strains were isolated from bullfrog breeding ponds, the sewage outlet, and downstream river in Zhejiang Province, China. These strains carry a novel Tet(X) variant, differing from Tet(X6) by seven residues, and possess the ability to degrade tetracyclines. Interestingly, the novel Tet(X) is a recombinant variant formed by homologous recombination of Tet(X6) and the C-terminal of Tet(X2). Further analysis revealed that Tet(X6) formed several Tet(X) variants, including Tet(X5), through homologous recombination. The novel tet(X) gene is located on a circularizable integrative and conjugative element (ICEEmeChn3), with ISwz1 participating in the recombination of its multi-drug resistance region, potentially facilitating the mobilization and recombination of tet(X) in early hosts. These three strains were clonally transmitted and shared a close genetic relationship (SNP &lt; 62) with a clinically-sourced strain isolated from the same province.DiscussionTo our knowledge, this is the first report of homologous recombination between Tet(X) variants with differing activities. These clonal strains provide evidence of the transmission of tet(X)-positive strains from aquaculture sewage to the natural environment, highlighting the need to strengthen the monitoring and management of this emerging farming model.
Association between preoperative sarcopenia and postoperative delirium in older patients undergoing gastrointestinal cancer surgery
Authors: Dong Bo , Yu Dongdong , Zhang Huanhuan , Li Pan , Li Yi , Li Chong , Li Jianli 
Published: July 2024

BackgroundPostoperative delirium (POD) is a usual neurological complication, often leading to poor prognoses. Early identification of high-risk patients is crucial for preventing POD. Sarcopenia is an age-related geriatric syndrome characterized by the loss of skeletal muscle mass and function, and previous studies indicated that preoperative low muscle mass might be a predictor for POD. However, the association between preoperative sarcopenia and POD remains to be fully elucidated. This study was to explore the correlation between preoperative sarcopenia and POD following gastrointestinal cancer surgery in older patients.MethodsOlder patients (≥60 years) undergoing gastrointestinal cancer surgery were enrolled. Sarcopenia was defined based on the Special Interest Group on sarcopenia of the International Society of Physical and Rehabilitation Medicine (ISarcoPRM), which combined the loss of muscle mass (evaluated by ultrasound) and function (assessed by chair stand test and handgrip strength) before surgery. POD assessment was performed using the Confusion Assessment Method (CAM) or CAM for the intensive care unit (CAM-ICU) during the first 7 days after surgery or before discharge. Multivariate logistic regression analysis examined the correlation between preoperative sarcopenia and POD. Moreover, the receiver operator characteristic (ROC) curve was applied to analyze the predictive effect of the preoperative sarcopenia in POD.ResultsOne hundred and thirty patients were finally included, of which 43 patients presented with sarcopenia before surgery. Twenty-four patients ultimately developed POD, and the incidence was 18.5%. The results of the multivariate analyses demonstrated that preoperative sarcopenia was still independently associated with POD after adjusting for age ≥70 years, preoperative Mini-Mental State Examination score, and intraoperative blood transfusion. The area under the ROC curve of preoperative sarcopenia in predicting POD was 0.680 (95% confidence interval 0.557–0.804).ConclusionPreoperative sarcopenia defined by ISarcoPRM criteria was independently associated with POD in geriatric patients after gastrointestinal cancer surgery.
Correlations of erythrocytic oligomer α-synuclein levels with age, sex and clinical variables in patients with Parkinson’s disease
Authors: Lu Zhe , Yu Xiaohan , Li Pengjie , Wang Yiming , Deng Yeyun , Li Xin , Wang Chaodong , Yu Shun 
Published: July 2024

IntroductionOligomeric alpha-synuclein in red blood cells (RBC-o-α-Syn) has been shown to be increased in patients with Parkinson’s disease (PD). However, factors that affect RBC-o-α-Syn levels remain to be elucidated. The aim of this study is to analyze the correlations between RBC-o-α-Syn levels and the age, sex and different clinical variables of patients with PD.Methods167 patients with PD and 119 healthy controls (HC) were enrolled in this study. The patients with PD were diagnosed based on the MDS clinical diagnostic criteria for PD. All participants were evaluated for their clinical characteristics. Western blot analysis was used to examine the molecular sizes of RBC-o-α-Syn. A newly established chemiluminescent immunoassay was used to measure RBC-o-α-Syn levels.ResultsHigher RBC-o-α-Syn levels were detected in PD patients than in HC subjects. The receiver operating characteristic (ROC) curve indicated that a cut off value of 55.29 ng/mg discriminated well between PD patients and HC subjects, with a sensitivity of 67.66% (95% CI: 60.24–74.29%), a specificity of 88.24% (95% CI: 81.22–92.86%), and an area under the curve (AUC) of 0.857. The levels of RBC-o-α-Syn were higher in female than male patients (p = 0.033). For different subtypes, the levels of RBC-o-α-Syn were higher in the MIX subtype than the tremor-dominant (TD) PD. In addition, the levels of RBC-o-α-Syn were higher in patients with than without cognitive impairment (p = 0.016), and negatively correlated with Mini-Mental State Examination (MMSE) scores (r = −0.156, p = 0.044).ConclusionOur study demonstrates that RBC-o-α-Syn levels in patients with PD are higher than those in HC subjects and affected by the sex and the severity of cognitive impairment.