bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive predictors of response to interpersonal and social rhythm therapy in mood disorders
Authors: Groves Samantha J. , Douglas Katie M. , Crowe Marie T. , Inder Maree , Jordan Jenny , Carlyle Dave , Beaglehole Ben , Mulder Roger , Lacey Cameron , Luty Sue , Eggleston Kate , Frampton Chris , Bowie Christopher R. , Porter Richard J. 
Published: August 2024

AbstractBackgroundThere has been increasing interest in examining the potential moderating effects that cognitive functioning has on treatment outcome in bipolar disorder (BD) and major depressive disorder (MDD). Therefore, the aim of this exploratory study was to examine the relationship between baseline cognitive function and treatment outcome in individuals with mood disorders who completed 12 months of interpersonal and social rhythm therapy (IPSRT), and were randomised to receive adjunctive cognitive remediation (CR) or no additional intervention.MethodsFifty‐eight patients with mood disorders (BD, n = 36, MDD, n = 22), who were randomised to IPSRT‐CR or IPSRT, underwent cognitive testing at baseline and completed follow‐up mood measures after 12 months. General linear modelling was used to examine the relationship between baseline cognitive function (both objective and subjective) and change in mood symptom burden, and functioning, from baseline to treatment‐end.ResultsPoorer baseline attention/executive function was associated with less change in mood symptom burden, particularly depressive symptoms, at treatment‐end. Additionally, slower psychomotor speed at baseline was associated with less improvement in mania symptom burden. Subjective cognitive function at baseline was not related to change in mood symptom burden at treatment‐end, and neither objective nor subjective cognitive function was associated with functional outcome.LimitationsDue to the exploratory nature of the study, there was no correction for multiple comparisons.ConclusionAspects of objective cognitive function were associated with treatment outcomes following psychotherapy. Further large‐scale research is required to examine the role that cognitive function may have in determining various aspects of mood disorder recovery.
Comparison of T1‐weighted landmark placement and ROI transfer onto diffusion‐weighted EPI sequences for targeted tractography tasks in the optic nerve
Authors: Janko Markus , Santaniello Sascha D. , Brockmann Carolin , Wolf Marcel , Grauhan Nils F. , Schöffling Vanessa I. , Dimova Violeta , Ponto Katharina , Hoffmann Esther M. , Kleinekofort Wolfgang , Othman Ahmed E. , Brockmann Marc A. , Kronfeld Andrea 
Published: August 2024

AbstractDiffusion‐based tractography in the optic nerve requires sampling strategies assisted by anatomical landmark information (regions of interest [ROIs]). We aimed to investigate the feasibility of expert‐placed, high‐resolution T1‐weighted ROI‐data transfer onto lower spatial resolution diffusion‐weighted images.Slab volumes from 20 volunteers were acquired and preprocessed including distortion bias correction and artifact reduction. Constrained spherical deconvolution was used to generate a directional diffusion information grid (fibre orientation distribution‐model [FOD]). Three neuroradiologists marked landmarks on both diffusion imaging variants and structural datasets. Structural ROI information (volumetric interpolated breath‐hold sequence [VIBE]) was respectively registered (linear with 6/12 degrees of freedom [DOF]) onto single‐shot EPI (ss‐EPI) and readout‐segmented EPI (rs‐EPI) volumes, respectively. All eight ROI/FOD‐combinations were compared in a targeted tractography task of the optic nerve pathway.Inter‐rater reliability for placed ROIs among experts was highest in VIBE images (lower confidence interval 0.84 to 0.97, mean 0.91) and lower in both ss‐EPI (0.61 to 0.95, mean 0.79) and rs‐EPI (0.59 to 0.86, mean 0.70).Tractography success rate based on streamline selection performance was highest in VIBE‐drawn ROIs registered (6‐DOF) onto rs‐EPI FOD (70.0% over 5%‐threshold, capped to failed ratio 39/16) followed by both 12‐DOF‐registered (67.5%; 41/16) and nonregistered VIBE (67.5%; 40/23). On ss‐EPI FOD, VIBE‐ROI‐datasets obtained fewer streamlines overall with each at 55.0% above 5%‐threshold and with lower capped to failed ratio (6‐DOF: 35/36; 12‐DOF: 34/34, nonregistered 33/36).The combination of VIBE‐placed ROIs (highest inter‐rater reliability) with 6‐DOF registration onto rs‐EPI targets (best streamline selection performance) is most suitable for white matter template generation required in group studies.
T. H. Green and Henry Sidgwick on free agency and the guise of the good
Authors: Sheng E. E. 
Published: August 2024

AbstractThe history of the thesis of the guise of the good between Kant and Anscombe is not well understood. This article examines a notable disagreement over the thesis during this period, between Green and Sidgwick. It shows that Green accepts versions of the thesis concerning action and desire in one sense of “desire,” and that Sidgwick rejects the thesis concerning both action and desire. It then considers why Green accepts the thesis, and how effective Sidgwick's criticism of Green is. Despite the appearance of a mere clash of intuitions, an interesting rationale for the thesis can be found in Green's theory of free will and moral responsibility, of which I defend a broadly compatibilist interpretation. Sidgwick's criticisms either miss this rationale altogether, or do not take adequately into account Green's complex theory of free will.
Culturally Sensitive Perinatal Mental Health Care: Experiences of Women From Minority Ethnic Groups
Authors: Gardner Angelene , Oduola Sheri , Teague Bonnie 
Published: August 2024

AbstractBackgroundCurrent research has identified how ethnic minority women experience poorer health outcomes during the perinatal period. In the United Kingdom, specialist perinatal mental health services provide mental health treatment for women throughout the perinatal period. Service users have previously highlighted that perinatal services are hard to access and lack cultural sensitivity, whereas healthcare professionals have described limited opportunities and resources for developing cultural competency.ObjectivesWe explored the experiences of ethnic minority women with National Health Service (NHS) specialist perinatal teams and identified what culturally sensitive perinatal mental health care means to this group.DesignIndividual semi‐structured interviews were conducted, and an interpretative phenomenological analysis framework was used to analyse the interview transcripts.Setting and ParticipantsParticipants were recruited from NHS specialist perinatal teams and online via social media.ResultsSix women were interviewed. Four group experiential themes central to the experiences of participants emerged: (1) strengthening community networks and peer support; (2) valuing cultural curiosity; (3) making sense of how culture, ethnicity, race and racism impact mental health; and (4) tailoring interventions to ethnic minority women and their families.Discussion and ConclusionsThe findings capture how ethnic minority women experience specialist perinatal teams and offer insights into practising culturally sensitive care. Perinatal mental health professionals can support ethnic minority women by strengthening their access to community resources and peer support; being curious about their culture; helping them to make sense of how culture, ethnicity, race and mental health interact; and applying cultural and practical adaptations to interventions.Patient or Public ContributionA Lived Experience Advisory Group (LEAG) of women from ethnic minority groups contributed to the design and conduct of this study. The LEAG had lived experience of perinatal mental health conditions and accessing specialist perinatal teams. The LEAG chose to co‐produce specific aspects of the research they felt fit with their skills and available time throughout five group sessions. These aspects included developing the interview topic guide, a structure for debriefing participants and advising on the social media recruitment strategy.
Revisiting X‐linked congenital ichthyosis
Authors: Zhou Baishun , Liang Cancan , Li Peiyao , Xiao Heng 
Published: August 2024

AbstractX‐linked recessive ichthyosis (XLI) is a hereditary skin disease characterized by generalized dryness and scaling of the skin, with frequent extracutaneous manifestations. It is the second most common type of ichthyosis, with a prevalence of 1/6,000 to 1/2,000 in males and without any racial or geographical differences. The causative gene for XLI is the steroid sulfatase gene (STS), located on Xp22.3. STS deficiency causes an abnormal cholesterol sulfate (CS) accumulation in the stratum corneum (SC). Excess CS induces epidermal permeability barrier dysfunction and scaling abnormalities. This review summarizes XLI's genetic, clinical, and pathological features, pathogenesis, diagnosis and differential diagnoses, and therapeutic perspectives. Further understanding the role of the STS gene pathogenic variants in XLI may contribute to a more accurate and efficient clinical diagnosis of XLI and provide novel strategies for its treatment and prenatal diagnosis.
Risk factor prediction and immune correlation analysis of cuproptosis‐related gene in osteoarthritis
Authors: Che Jingmin , Yang Xiaoli , Zhao Xiangrong , Li Yan , Jin Zhankui , Xu Cuixiang 
Published: August 2024

AbstractOsteoarthritis (OA) is a widespread inflammatory joint disease with significant global disability burden. Cuproptosis, a newly identified mode of cell death, has emerged as a crucial factor in various pathological conditions, including OA. In this context, our study aims to investigate the intrinsic relationship between cuproptosis‐related genes (CRGs) and OA, and assess their potential as biomarkers for OA diagnosis and treatment. Datasets from the GEO databases were analysed the differential expression of CRGs, leading to the identification of 10 key CRGs (CDKN2A, DLD, FDX1, GLS, LIAS, LIPT1, MTF1, PDHA1, DLAT and PDHB). A logistic regression analysis and calibration curves were used to show excellent diagnostic accuracy. Consensus clustering revealed two CRG patterns, with Cluster 1 indicating a closer association with OA progression. RT‐PCR confirmed a significant increase in the expression levels of these nine key genes in IL‐1β‐induced C28/i2 cells, and the expression of CDKN2A and FDX1 were also elevated in conditioned monocytes, while the expression of GLS and MTF1 were significantly decreased. In vitro experiments demonstrated that the expression levels of these 7/10 CRGs were significantly increased in chondrocytes induced by IL‐1β, and upon stimulation with cuproptosis inducers, chondrocyte apoptosis was exacerbated, accompanied by an increase in the expression of cuproptosis‐related proteins. These further substantiated our research findings and indicated that the nine selected cuproptosis genes have high potential for application in the diagnosis of OA.
Investigating the altered expression of miR‐486‐5p and miR‐novel‐chr1_40444 in dysglycemia in a South African population
Authors: Weale Cecil J , Schroeder Chanelle , Matshazi Don M , Davids Saarah FG , Erasmus Rajiv T , Kengne Andre P , Davison Glenda M , Matsha Tandi E 
Published: August 2024

AbstractAimsThis study aims to investigate miR‐486‐5p and miR‐novel‐chr1_40444 expressions in dysglycemic individuals. Validating RNA‐sequencing findings in a larger sample via reverse transcription qPCR (RT‐qPCR), we aim to address global diagnostic and screening limitations, using an African cohort as an example.Materials and MethodsThis cross‐sectional study involved 1,271 individuals [normoglycemic (n = 974), prediabetic (n = 206), screen‐detected type 2 diabetes (n = 91)] from the ongoing Vascular and Metabolic Health (VMH) study in Cape Town, South Africa. Whole blood miRNA expression was assessed using TaqMan‐based RT‐qPCR, with data normalized to an endogenous control (miR‐16‐5p).ResultsSignificant underexpression was observed in prediabetes vs normoglycemia for miR‐486‐5p (P = 0.038), whilst both miRNAs demonstrated significant upregulation in screen‐detected type 2 diabetes vs normoglycemia (miR‐486‐5p, P = 0.009; miR‐novel‐chr1_40444, P < 0.001), and screen‐detected type 2 diabetes in comparison with prediabetes (miR‐486‐5p, P < 0.001; miR‐novel‐chr1_40444, P < 0.001). Multivariable regression analyses revealed pronounced interrelations between miR‐novel‐chr1_40444 and screen‐detected type 2 diabetes in unadjusted and adjusted models (Model 1: P < 0.001, Model 2: P < 0.001, Model 3: P = 0.030). Moreover, receiver operating characteristic (ROC) curves revealed significantly enhanced diagnostic capabilities for screen‐detected type 2 diabetes vs either normoglycemia (AUC = 0.971, P < 0.001), non‐diabetes (AUC = 0.959, P < 0.001), or prediabetes (AUC = 0.902, P < 0.001) when combining the miRNAs with 2 h postprandial glucose.ConclusionsThis study demonstrated the enhanced power of incorporating miRNAs with traditional markers in distinguishing screen‐detected type 2 diabetes, warranting further investigations on their unique role in the development of type 2 diabetes.
Development of a predictive model for assessing quality of winter jujube during storage utilizing hyperspectral imaging technology
Authors: Wei Yuqing , Liu Quancheng , Fan Shuxiang , Jiang Xinna , Chen Yun , Wang Fan , Cao Xingda , Yan Lei 
Published: August 2024

AbstractThe necessity for precise determination of fruit storage durations is paramount in both industrial and domestic spheres, with hyperspectral imaging (HSI) technology emerging as a pivotal tool for prognosticating the physicochemical attributes indicative of mature fruit quality. This investigation employed hyperspectral imaging to conduct a noninvasive analysis of variations in soluble solids content (SSC), hardness, and moisture content (MC) in jujube fruit over the course of storage at divergent temperatures. Throughout the storage intervals (0, 7, 14, and 21 days) at varying temperatures (4 and 20°C), both physicochemical and spectral data were amassed. The raw spectral information underwent preprocessing through multiple scattering correction (MSC), standard normal variation (SNV), and Savitzky–Golay (SG) algorithms to refine the methodologies for SSC, hardness, and moisture content. Subsequently, the competitive adaptive reweighted sampling (CARS) algorithm facilitated the discernment and elimination of extraneous variables, thereby enhancing feature wavelength extraction. This process underpinned the development of partial least squares regression (PLSR), back propagation (BP), and genetic algorithm‐back propagation (GA‐BP) models predicated on CARS‐derived features, culminating in the selection of an optimal model. The findings underscore the capability of hyperspectral imaging technology to swiftly and nondestructively ascertain the SSC, hardness, and MC of jujube throughout the storage phase, thereby enabling the assessment of quality attributes over varying storage durations and facilitating the surveillance of jujube quality maintenance during storage.Practical ApplicationsThe winter jujube garners appreciation from consumers owing to its exquisite flavor, yet its quality diminishes over time in storage due to various factors, thereby impacting its market value. Consequently, it is imperative to surveil the quality alterations of jujube throughout its storage to mitigate the degradation of its quality. Hyperspectral imaging technology offers a sophisticated means to forecast the physicochemical index changes indicative of the fruit's quality at maturity. This research delineates the development of predictive models for the soluble solids, hardness, and moisture content of jujube at divergent temperatures throughout the storage interval, selecting the paramount model through a holistic assessment, thereby fully harnessing the capabilities of hyperspectral imaging technology in monitoring jujube quality during storage. Moreover, the methodology employed herein is adaptable to other fruits in storage, harboring the potential for future application in the real‐time quality monitoring of fruits as they exit the storage facilities.
Effect of temperature on the rheological, textural, and sensory properties of butters from New Zealand market
Authors: Yang X. , Saunders A. , Mohan M. S. 
Published: August 2024

AbstractTexture and sensory studies at various temperatures are important in evaluating and improving the functionality of butter. While literature is scarce, we evaluated and compared the effect of temperature (5–25°C) on the texture, rheological and sensory properties of commercial butter samples (salted, unsalted, cultured, and spreadable) from the New Zealand market. In addition, the instrumental analyses were compared with the sensory evaluation, to understand the possibility of using instrumental analysis to evaluate consumer liking for different butters. Butter type, temperature, and their type–temperature interaction exhibited significant differences for all instrumental textural parameters. As expected, higher temperature produced softer butter that was more spreadable, liquid‐like, less adhesive, less cohesive, had lower storage modulus (G′) and lower loss modulus (G″) with the melting of milk fat crystals; however, the rate of change varied for the different butter samples. We have established meltability as the parameter for evaluating butter selection for different applications. The spreadable butter sample exhibited the lowest hardness and G′, and highest spreadability (p < .05) at all temperatures, owing to its low solid fat content and the abundance of low‐melting triglycerides. The cultured butter sample had the highest melting point, owing to compositional differences. The instrumental and sensory texture analyses were highly correlated, indicating the comparative effectiveness of both approaches for studying the effects of different temperatures on butter textural properties. Overall, our findings provide detailed reference to the dairy industry for butter manufacture, considering variation in fatty acid composition, texture analysis, rheology, and sensory analysis, over the range of storage/usage temperatures.
Genotypic and phenotypic characterisation of a nosocomial outbreak of Candida auris in Spain during 5 years
Authors: Mulet‐Bayona Juan Vicente , Cancino‐Muñoz Irving , Salvador‐García Carme , Tormo‐Palop Nuria , Guna‐Serrano María del Remedio , Ferrer‐Gómez Carolina , Melero‐García Mercedes , González‐Candelas Fernando , Gimeno‐Cardona Concepción 
Published: August 2024

AbstractObjectivesThe investigation of Candida auris outbreaks is needed to provide insights into its population structure and transmission dynamics. We genotypically and phenotypically characterised a C. auris nosocomial outbreak occurred in Consorcio Hospital General Universitario de Valencia (CHGUV), Spain.MethodsData and isolates were collected from CHGUV from September 2017 (first case) until September 2021. Thirty‐five isolates, including one from an environmental source, were randomly selected for whole genome sequencing (WGS), and the genomes were analysed along with a database with 335 publicly available genomes, assigning them to one of the five major clades. In order to identify polymorphisms associated with drug resistance, we used the fully susceptible GCA_003014415.1 strain as reference sequence. Known mutations in genes ERG11 and FKS1 conferring resistance to fluconazole and echinocandins, respectively, were investigated. Isolates were classified into aggregating or non‐aggregating.ResultsAll isolates belonged to clade III and were from an outbreak with a single origin. They clustered close to three publicly available genomes from a hospital from where the first patient was transferred, being the probable origin. The mutation VF125AL in the ERG11 gene, conferring resistance to fluconazole, was present in all the isolates and one isolate also carried the mutation S639Y in the FKS1 gene. All the isolates had a non‐aggregating phenotype (potentially more virulent).ConclusionsIsolates are genotypically related and phenotypically identical but one with resistance to echinocandins, which seems to indicate that they all belong to an outbreak originated from a single isolate, remaining largely invariable over the years. This result stresses the importance of implementing infection control practices as soon as the first case is detected or when a patient is transferred from a setting with known cases.
The importance of facilitative interactions in mediating climate change impact on biodiversity
Authors: Kéfi Sonia , Lortie C J. , Cavieres Lohengrin A. 
Published: August 2024

Global change is a multifaceted, unprecedented crisis hitting the life support system of our planet. Among global changes, climate change is regarded as one of the most grave threats to biodiversity because of its direct impacts on species and ecosystems integrity and because of its indirect consequences through synergistic effects with other global change factors such as biological invasions. The challenges presented to either reduce or mitigate this biodiversity crisis derived from climate change require novel synthesis and innovation in ecological and evolutionary theory. Positive species interactions within and between trophic levels can play a key role in the resilience of ecological communities. Depending on the tolerance of nurse species to different aspects of climate change, communities can be more or less resilient to those changes. This knowledge has important implications for both natural communities and agroecosystems. Further, our fundamental understanding of the role of positive interactions can also enable both effective conservation and restoration levers in space and time.This special issue includes studies addressing the role of facilitative interactions on the response of ecological systems to climate change. Key concepts examined included stress, gradients, nurse species, spatial scale, translocation, phylogenetics alongside physiochemicals, and variation in the capacity of species to buffer changes. Alpine, tundra, drylands and temperate forests were directly tested, but salient principles were relevant to all ecosystems including a contribution on soil biota and also a call to more open data and collaborative science. Together, this corpus of work highlighted the significance of facilitative interactions in mitigating many of the effects of climate change on biodiversity.
Agent Causation and Motivating Reasons
Authors: Martinez Joseph 
Published: August 2024

AbstractAgent causation, roughly stated, is the view that an agent can stand in direct causal relation to (at least some subset of) her actions. Although agent causation has had a patchy reputation throughout much of contemporary analytic philosophy, it is now considered by many to be a viable theoretical option in various domains in action theory. That said, agent‐causalists continue to grapple with a number of important issues. This paper focuses on one such issue—namely, how to integrate motivating reasons into a picture of agent causation. More specifically, I canvass a number of options for the agent‐causalist, focusing in particular on various causalist accounts, and flagging various problems along the way. I conclude with some brief considerations about how to move forward.