bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cystine and urate cystoliths in dogs are frequently visible on radiographs prior to surgical or nonsurgical removal
Authors: Andrews Camille , Williams Rachel , Arjoonsingh Avin , Vilaplana Grosso Federico R. 
Published: July 2024

Abstract

OBJECTIVE
To investigate the frequency at which cystine and urate cystoliths (stones) are visible on radiographs prior to surgical or nonsurgical retrieval.

METHODS
Records of client-owned dogs (n = 331) were analyzed between January 2019 and December 2023 for cystoliths submitted for stone analysis after surgical removal or nonsurgical retrieval. Records were analyzed for cystolith type; when cystine or urate stones were identified, records were analyzed for signalment, procedure, presence of mineral opaque cystoliths on pre-procedural radiographs, urine pH and crystalluria, history of previous cystoliths, prior prescription diet attempt, recurrence, and genetic, congenital and acquired comorbidities. Descriptive statistics were generated after data collection.

RESULTS
31 of 331 (9%) were cystine stones, 49 of 331 (15%) were urate, and 1 of 331 (0.3%) was a mix of urate and cystine. When radiographs were taken prior to stone removal, 24 of 28 (85%) of urate, 24 of 26 (92%) of cystine, and 1 of 1 (100%) of urate/cystine were visible on radiographs.

CONCLUSIONS
Cystine and urate stones are visible on survey radiography at a high frequency in dogs.

CLINICAL RELEVANCE
While cystine and urate stones have been historically designated as radiolucent, they are frequently radiopaque on radiographs. Radiopacity is commonly used as one of the criterion to determine whether a dissolution or prevention diet is an appropriate management technique, particularly when determination of the stone type has yet to be performed. As a result, these findings may prompt clinicians to investigate other patient-specific factors before a specific dietary recommendation is made.
Ultrasound is an accurate imaging modality for diagnosing hip luxation in dogs presenting with hind limb lameness
Authors: Todd-Donato Amy B. , VanDeventer Gretchen M. , Porter Ian R. , Krotscheck Ursula 
Published: July 2024

Abstract

OBJECTIVE
To determine the accuracy of ultrasound for diagnosing hip luxation in dogs presenting for hind limb lameness.

METHODS
24 client-owned dogs presenting with pelvic limb lameness and concern for hip luxation were enrolled in this prospective diagnostic accuracy study from April 1, 2021, to July 1, 2022. An experienced ultrasonographer and a novice ultrasonographer, both masked to the diagnoses, performed hip ultrasonography using a point-of-care ultrasound machine. The experienced evaluator also performed a more comprehensive ultrasonography with a high-end ultrasound machine to characterize concurrent pelvis and hip disease. Pelvic radiographs served as the criterion standard for the diagnosis of hip luxation.

RESULTS
Ultrasonographic diagnosis of hip luxation demonstrated high accuracy, ranging from 84.2% to 100% for detecting the presence of luxation and 80.6% to 98.1% for diagnosing the direction of luxation for the novice and experienced evaluators, respectively, with substantial interevaluator agreement (κ = 0.722). Compared to radiographs, ultrasound accurately diagnosed the presence of osteoarthrosis with almost perfect agreement (κ = 0.913) and the presence of fractures of the femoral head/neck and the nonaxial portions of the pelvis with substantial intermodality agreement (κ = 0.775). In 36% of patients, ultrasound identified injury to soft tissue structures that contribute to hip stability, including the gluteal muscles, gemelli, and joint capsule.

CONCLUSIONS
Ultrasound can be utilized to accurately diagnose the presence of hip luxation and document concurrent hip and pelvic disease.

CLINICAL RELEVANCE
Applications include the use of ultrasonography as part of a routine point-of-care protocol to catalogue injuries in patients with acute trauma and in mobile practice or remote settings where radiography is not readily available.
Rabies surveillance in the United States during 2022
Authors: Ma Xiaoyue , Boutelle Cassandra , Bonaparte Sarah , Orciari Lillian A. , Condori Rene E. , Kirby Jordona D. , Chipman Richard B. , Fehlner-Gardiner Christine , Thang Cin , Cedillo Veronica Gutiérrez , Aréchiga-Ceballos Nidia , Nakazawa Yoshinori , Wallace Ryan M. 
Published: July 2024

Abstract

OBJECTIVE
To provide comprehensive epidemiological information about the distribution and occurrence of rabies during 2022 in the US, Canada, and Mexico.

METHODS
The US National Rabies Surveillance System collected 2022 animal rabies data from US state and territorial public health departments and USDA Wildlife Services. Temporal and geographic analyses were conducted to evaluate trends in animal rabies cases.

RESULTS
During 2022, 54 US jurisdictions reported 3,579 animal rabies cases, reflecting a 2.3% decline from 3,663 cases reported in 2021. Six states collectively reported > 50% of animal rabies cases: Texas (395 [11.0%]), Virginia (337 [9.4%]), Pennsylvania (329 [9.2%]), New York (267 [7.5%]), North Carolina (264 [7.4%]), and California (241 [6.7%]). Out of the total reported rabies animal cases, 3,234 (90.4%) were attributed to wildlife, with bats (1,218 [34.0%]), raccoons (1,014 [28.3%]), skunks (660 [18.4%]), and foxes (269 [7.5%]) representing the primary hosts confirmed with rabies. Rabid cats (222 [6.2%]), cattle (42 [1.2%]), and dogs (50 [1.4%]) constituted > 90% of reported domestic animal rabies cases.

CONCLUSIONS
In 2022, there was an increase in the number of animal samples submitted for rabies testing in the US and Canada. A notable geographic expansion of gray fox rabies virus variant was detected in the US. Three human rabies deaths due to vampire bat rabies infection occurred in Mexico; none were reported from the US and Canada.

CLINICAL RELEVANCE
Laboratory diagnosis of rabies in animals is critical to ensure judicious use of human rabies postexposure prophylaxis.
A patient with Beta-Propeller Protein-Associated Neurodegeneration: a new missense mutation of the WDR45 gene
Authors: Ivanova Anastasia , Kulikova Sviatlana , Sivitskaya Larysa , Danilenko Nina , Davydenko Oleg 
Published: July 2024

Summary

Introduction
Beta-propeller protein-associated neurodegeneration (BPAN) is a neurodegenerative disorder; its estimated prevalence is 2 to 3 per million individuals. All published cases of BPAN have been sporadic, with a clear female predominance and mutations in various exons of the WDR45 gene.

Case presentation
The study aimed to confirm the diagnosis of BPAN in a 9-year-old girl with a developmental delay since early childhood complicated with intellectual disability, lack of speech and febrile and non-febrile tonic-clonic seizures. The patient also had autistic symptoms as well as some Rett-like symptoms: stereotypical movements of the hands–twisting objects, putting hands in the mouth.

Discussion
Clinical exome analysis and Sanger sequencing of the proband have been performed to confirm the diagnosis. The novel heterozygous missense mutation c.755T>C of the WDR45 «autophagy» gene was revealed. Sanger sequencing of the trio (proband and parents) proved the de novo nature of mutation; its clinical significance has been defined as probably pathogenic. Thus, we report a new missense variant of the WDR45 gene in a girl with a clinical picture of BPAN. The use of NGS made it possible to get a correct diagnosis during rather a short period before the second debilitating phase of the disease started so that the physicians and the family would have time to prepare and hopefully choose the way to resist.
EEG Patterns Predicting Clobazam Response in Refractory Status Epilepticus in Adults
Authors: Manmatharayan Arichena , Andrade-Machado Rene , Marawar Rohit , Lee Paul , Lagnf Abdalhamid , Souidan Hassan , Ataya Taha , Abdelhak Farah , Thomas Rohan , Fakhouri Rami , Motii Younes , Rehman Sarah , Durban Margerie , Parker Dennis , Mohamed Wazim , Elsayed Mona 
Published: July 2024

Summary

Background
Seizure resolution is often difficult to attain promptly in status epilepticus (SE). Clobazam (CLB) is structurally different from typical benzodiazepines with an affinity to the α2 subunit of GABA-A receptors, rendering unique efficacy in seizure termination.

Aim
To assess the response of clobazam in refractory status epilepticus (RSE) and to correlate this response with EEG patterns.

Materials and Methods
This was a single-center retrospective study conducted at a neurocritical care unit between January 2018 and June 2023. The study included fifty consecutive patients with RSE, out of which sixteen adult patients had continuous EEG monitoring both before and during treatment with clobazam until the resolution of RSE. Patients for whom clobazam was the last anti-seizure medication (ASM) used were included in the study. Thirty-four patients were excluded for various reasons, like lack of continuous EEG monitoring (cEEG), status post cardiac arrest, exclusion of clobazam due to medical issues or adverse events, or admission to the hospice floor.

Results
Out of the sixteen patients included in the study, twelve (75%) had focal nonconvulsive RSE on cEEG and four had focal convulsive RSE when clobazam was administered. Thirteen out of sixteen patients (81.25%) responded successfully to clobazam, with an average time of 23.5 hours since starting the medication. On average, three other ASMs were tried before clobazam, initiated at a mean time of 27 hours since SE onset. The study identified EEG patterns correlated with the use of clobazam :1) lateralised periodic discharges that evolved from 1–1.5 Hz to 2–3 Hz, then evolved to rhythmic theta/delta activity with embedded LPDs; 2) repetitive spikes that evolved to theta and delta frequencies (good responders to CLB), and iii) low voltage faster frequencies and evolved to theta delta frequencies (less responders to CLB).

Conclusion
Rapid pharmacoresistance to first-line benzodiazepines and ASM occurs as seizures persist during SE. Our study provides EEG correlates to the successful use of CLB in RSE based on its unique targeting of the GABA-A subtype receptors involved in postsynaptic phasic inhibition.
Deserción universitaria: el lema y el dilema desde los discursos de Lacan
Authors: Gonzalez Sabogal Diego Alejandro 
Published: July 2024

El presente ensayo es una elaboración desde el discurso psicoanalítico, que pretende analizar el fenómeno de la deserción universitaria, como un fenómeno producto de los lemas del discurso del amo y el discurso universitario que desarrolla Lacan, en el que se encuentra una educación homogeneizadora del sujeto que apunta a que sea para todos por igual y a los ideales del mercado, de la educación profesionalizante, de las pedagogías de la razón y del saber como totalidad que configuran el nexo entre la institución y el sujeto.
Es menester por tanto acoger el dilema como el conflicto que atraviesa la singularidad con las propuestas del psicoanálisis y de las pedagogías críticas que permitan movilizar los lugares comunes de pasividad y homogeneización que generan síntomas en el lazo social como el de la deserción, y pasar a dar una mayor cabida a la singularidad y a las aberturas institucionales.
cocina de lo comunitario femenino
Authors: Díaz Lozano Juliana 
Published: July 2024

Este artículo analiza las prácticas de colectivización de los cuidados que realizan mujeres de sectores populares en el barrio Villa Argüello de Berisso, parte de ellas en el marco de la organización social Frente Popular Darío Santillán Corriente Nacional de Argentina. Se enfoca su trabajo en los comedores populares, donde, al tiempo que gestionan en común el alimento y el cuidado de niños y niñas, construyen tramas políticas que sostienen la estructura organizativa y la protesta.
Se reflexiona sobre la coexistencia de una dinámica de sobrecarga de trabajo, con la habilitación de márgenes de autonomía a partir de dicha participación cotidiana. Se concluye que los saberes femeninos en relación con los cuidados como experiencia histórica, pueden motorizar modos particulares de hacer política denominados “política en femenino[1]”.

[1] Retomamos este concepto trabajado por Raquel Gutiérrez Aguilar (2015) “Políticas en femenino. Transformaciones y subversiones no centradas en el Estado”. Revista Contrapunto, 7, pp. 123-139.
Autoras de cómics e investigadoras de historieta. Una alianza para forjar genealogías feministas en América Latina
Authors: Acevedo Mariela Alejandra 
Published: July 2024

El artículo presenta una reflexión en torno a la forma en la que se construye el campo de los estudios de historieta y humor gráfico feminista en América Latina. La especificidad delinea fronteras y señala algunos problemas que nos proponemos recorrer. En primer lugar, la posibilidad de darle entidad a una línea de estudios al interior del campo de los estudios de lo que ampliamente reconocemos como narrativas dibujadas. Nos interesa pensar allí cómo se distinguen líneas de investigación que apuntan al análisis de contenidos sexistas en la producción de autores y autoras, a la recuperación de la historia invisibilizada de las autoras que disputaron un campo hegemonizado por la mirada y la presencia masculina o se dedican al abordaje del panorama actual de una escena de producción y edición de historietas militante (feminista y LGTBQ+). En segundo lugar, nos interesa poner en diálogo la experiencia de investigadoras/es que desde distintas coordenadas trabajaron en estas cuestiones lo que implica forjar una genealogía de estas líneas investigativas también en los estudios que se vienen realizando en la región y en el mundo. La genealogía tiene así una doble vía: la construcción del campo de producción de historieta feminista/lgtbq+ y el de las investigaciones que dieron cuenta de ésta producción, ambas tienen una historia en la región y una dimensión conflictiva que implica entender los mecanismos de visibilidad/invisibilidad y las posibilidades de acceso y permanencia tanto en la producción de historietas como en la de su recepción crítica desde la academia.
Y la brisa se convirtió en terremoto. El aislamiento por el Covid-19 en la Matanza
Authors: De Sena Angélica 
Published: July 2024

En marzo del año 2020 llega el primer caso de Covid-19 a la Argentina y a partir de ello y de modo temprano se declara el asilamiento de la población, al igual que en otros países, ello significo el cierre de múltiples actividades y solo era posible la realización de las consideradas esenciales. Ello trajo también cambios en el trabajo, la educación, la cotidianeidad, las interacciones sociales y la necesidad de incorporar nuevos hábitos, junto con la familiarización de cierto discurso medico se debía mantener distancia entre seres humanos por lo menos 1,80 metros, a lavarse las manos de modo permanente, al uso de alcohol, barbijos, y quedarse en sus respectivas viviendas. Esta forma de encierro llego a preguntarse por la condiciones efectivas de poder cumplirlas, dada las múltiples situaciones de vulnerabilidad pre-existente. En dicho contexto iniciamos una indagación en el partido de La Matanza (el más populoso del Gran Buenos Aires) efectos de comenzar a responder cómo se operacionaliza los nuevos preceptos: “quedate en casa”, “lávate las manos”, considerando las situación pre-pandemia. Para ello se realiza una descripción de dicho territorio, luego se revisan la posibilidad de cumplimiento de los autocuidados.

Palabras claves: cuarentena- vulnerabilidad social y económica- La Matanza-
Unilateral naevoid telangiectasia: A retrospective study of 11 paediatric cases
Authors: He Rui , Zhang Nan , Guo Wu , Ma Lin , Xu Zigang , Zhang Bin 
Published: July 2024

Background
Unilateral naevoid telangiectasia (UNT) is a rare disease with only sporadic cases reported. The pathogenesis remains elusive and especially in paediatric patients, effective and safe treatment is still uncertain.

Objectives
The purpose of this study was to summarise the clinical characteristics of UNT, explore the possible pathogenesis and evaluate the efficacy and safety of pulsed dye laser (PDL) therapy.

Methods
The epidemiological data, clinical manifestations, laboratory tests and pathological features of paediatric patients with UNT were retrospectively reviewed. PDL treatment was done on some of the patients. Clinical documents and patient images before and after treatment were assessed to evaluate efficacy and adverse events.

Results
Most of the cases (9/11) presented with unilateral lesions. The laboratory results of all the 11 cases were normal. Histological examination in six cases revealed multiple, dilated veins in the reticular dermis. Vascular endothelial growth factor (VEGF) staining was positive, whereas oestrogen receptor staining was negative. Nine cases were treated with PDL which was shown to be effective and safe.

Conclusion
UNT has typical clinical manifestations. The pathogenesis of this disease could be linked to VEGF; however, more research and confirmation are needed. PDL is an effective and safe treatment for UNT.
A retrospective cohort study of stereotactic radiosurgery for vestibular schwannomas: Comparison of two age groups (75 years or older vs. 65–74 years)
Authors: Watanabe Shinya , Yamamoto Masaaki , Aiyama Hitoshi , Sugii Narushi , Matsuda Masahide , Akutsu Hiroyoshi , Ishikawa Eiichi 
Published: July 2024

Background:Treatment outcome data of stereotactic radiosurgery (SRS) for vestibular schwannomas (VS) in patients ≥75 years (late elderly) are lacking. Approximately 39% of patients ≥75 years with VS were reported to experience severe facial palsy after surgical removal. This study compared the treatment outcomes post-SRS for VS between patients ≥75 and 65–74 years (early elderly).Methods:Of 453 patients who underwent gamma knife SRS for VS, 156 were ≥65 years old. The late and early elderly groups comprised 35 and 121 patients, respectively. The median tumor volume was 4.4 cc, and the median radiation dose was 12.0 Gy.Results:The median follow-up periods were 37 and 56 months in the late and early elderly groups, respectively. Tumor volume control was observed in 27 (88%) and 95 (83%) patients (P= 0.78), while additional procedures were required in 2 (6%) and 6 (6%) patients (P= 1.00) in the late and early elderly groups, respectively. At the 60thand 120thmonths post-SRS, the cumulative tumor control rates were 87%, 75%, 85%, and 73% (P= 0.81), while the cumulative clinical control rates were 93% and 87%, 95%, and 89% (P= 0.80), in the late and early elderly groups, respectively. In the early elderly group, two patients experienced facial pain, and one experienced facial palsy post-SRS; there were no adverse effects in the late elderly group (bothP= 1.00).Conclusion:SRS is effective for VS and beneficial in patients ≥75 years old as it preserves the facial nerve.
Primary intracranial sarcoma, DICER-1 mutant, with hemorrhagic presentation: A case report
Authors: Edelbach Brandon Michael , Gospodarev Vadim , Raghavan Ravi , Dye Justin 
Published: July 2024

Background:
Primary intracranial sarcomas (PIS) are rare tumors with mesenchymal origins. These tumors have a heterogeneous clinical presentation and are associated with a poor prognosis.

Case Description:
This report highlights the complexities associated with PIS by focusing on a 26-year-old male with recurrent tumor growth facing unique challenges regarding diagnosis and treatment options . A high-grade spindle-celled neoplasm with sarcomatous features characterized the patient’s tumor. There were additional morphologic changes, including multinucleated giant cells and rare foci with eosinophilic spheroids. Genomic analysis revealed a DICER1-associated PIS. Treatment involved endovascular embolization, multiple surgical interventions, intrathecal etoposide injections, and oral pazopanib with adjuvant radiation therapy.

Conclusion:
This case additionally highlights an unusual association between PIS and anomalous hypervascularity, refractory hemorrhage, and subdural effusions, a presentation that is increasingly being reported in this type of tumor.
Multilevel thoracic spinal epidural angiolipoma
Authors: Wardhana Dewa Putu Wisnu , Lauren Christopher , Rosyidi Rohadi Muhammad 
Published: July 2024

Background:
Spinal epidural angiolipomas (SEAL) are rare benign tumors composed of mature adipose tissue and abnormal blood vessels. SEALs account for 0.04–1.2% of all spinal tumors and 2–3% of spinal extradural lesions. They are usually found in the mid-thoracic dorsal extradural region. Here, we present the case of a 52-year-old female with a rare SEAL involving multiple thoracic levels.

Case Description:
A 52-year-old female presented with mid-thoracic pain and paraparesis (motor strength 3/5 proximal/distal). Magnetic resonance imaging (MRI) documented a well-demarcated, homogeneous dorsal epidural mass extending from T7 to T10. She underwent a laminectomy for tumor resection and decompression. The tumor, measuring 6 × 2 × 0.5 cm, consisted of mature adipose tissue and abnormal blood vessels. Postoperatively, the patient’s motor deficit fully resolved within 6 months.

Conclusion:
SEAL is a rare extradural dorsal thoracic spine tumor that can be readily diagnosed with MRI. The gold standard of treatment is gross total resection through a laminectomy.
Full-endoscopic discectomy utilizing an interlaminar approach for gas-containing herniation at L5–S1
Authors: Ioroi Yoshihiko , Kawasaki Toshinari , Hashimoto Jun , Kobayashi Tamaki , Koga Hisashi , Takayama Motohiro 
Published: July 2024

Background:
Intradiscal gas is frequently observed in older patients with disc degeneration and can occasionally result in nerve root compression.

Case Description:
A 79-year-old male patient presented with increasing left lower extremity sciatica. Lumbar computed tomography (CT) and magnetic resonance (MR) images revealed a left paramedian L5–S1 gas-containing disc herniation. Utilizing an interlaminar approach, a full-endoscopic discectomy (FED) was performed at L5–S1. During disc removal, we countered intradiscal gas bubbles. Postoperatively, the patient’s symptoms/signs fully resolved, and follow-up MR and CT images revealed total resection of the disc herniation, and no further gas.

Conclusion:
Through an interlaminar FED, we effectively removed an L5–S1 MR/CT-documented gas-containing disc herniation.