bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of process parameters on the surface characteristics of laser powder bed fusion printed parts: machine learning predictions with random forest and support vector regression
Authors: Dejene Naol Dessalegn , Lemu Hirpa G. , Gutema Endalkachew Mosisa 
Published: July 2024

AbstractLaser powder bed fusion (L-PBF) fuses metallic powder using a high-energy laser beam, forming parts layer by layer. This technique offers flexibility and design freedom in metal additive manufacturing (MAM). However, achieving the desired surface quality remains challenging and impacts functionality and reliability. L-PBF process parameters significantly influence surface roughness. Identifying the most critical factors among numerous parameters is essential for improving quality. This study examines the effects of key process parameters on the surface roughness of AlSi10Mg, a widely used aluminum alloy in high-tech industries, fabricated by L-PBF. Part orientation, laser power, scanning speed, and layer thickness were identified as crucial parameters via cause-and-effect analysis. To systematically examine their effects, the Taguchi method was employed within the framework of the design of experiment (DoE). Experimental results and statistical analysis revealed that laser power, scanning speed, and layer thickness significantly influence surface roughness parameters: arithmetic mean (Ra) and root mean square (Rq). Main effect plots and energy density analyses confirmed their impact on surface quality. Microscopic investigations identified surface flaws such as spattering, balling, and porosity contributing to poor quality. Given the complex interplay between parameters and surface quality, accurately predicting their effects is challenging. To address this, machine learning models, specifically random forest regression (RFR) and support vector regression (SVR), were used to predict the effects on surface roughness. The RFR model’s R2 values for predicting Ra and Rq are 97% and 85%, while the SVR model’s predictions are 85% and 66%, respectively. Evaluation metrics demonstrated that the RFR model outperformed SVR in predicting surface roughness.
Pulmonary Atresia with Intact Ventricular Septum, a National Comparison Between Interventional and Surgical Approach, in Combination with a Systemic Literature Review
Authors: Manhem Stina , Odermarsky Michal , Wåhlander Håkan , Ekman-Joelsson Britt-Marie 
Published: July 2024

AbstractThis study aimed to compare long-term morbidity in patients with pulmonary atresia with intact ventricular septum (PA-IVS) treated with catheter-based intervention (group A) versus those undergoing heart surgery (group B) as initial intervention. Additionally, we conducted a systematic literature review on PA-IVS treatment. All neonates born in Sweden with PA-IVS between 2007 and 2019 were screened for inclusion. The inclusion criterion was decompression of the right ventricle for initial intervention. Medical records were reviewed, as well as the initial preoperative angiogram, and the diagnostic echocardiogram. Comparisons between groups were performed with Mann–Whitney U-test and Fisher´s exact test. A systematic literature review of original studies regarding treatment of PA-IVS (2002 and onward) was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, to assess the outcomes of patients with PA-IVS. 34 (11 females) patients were included, 18 in group A and 16 in group B. There was no mortality in either group. Follow-up time ranged from 2 to 15 years (median 9). All attempted perforations in group A were successful, and 16 out of 18 patients reached biventricular circulation. In the surgical group 15 out of 16 patients reached biventricular circulation. The literature review presented heterogeneity in standards for treatment. This retrospective population-based multicenter study demonstrates that both catheter-based intervention and heart surgery are safe procedures. Our results are comparable to, or exceed, those in the systematic literature review. The systematic literature review displays a great heterogeneity in study design, with no definitive golden standard treatment.
In vitro T cell responses to PD-1 blockade are reduced by IFN-α but do not predict therapy response in melanoma patients
Authors: Timmerman Laura M. , Hensen Lobke C. M. , van Eijs Mick J. M. , Verheijden Rik J. , Suijkerbuijk Karijn P. M. , Meyaard Linde , van der Vlist Michiel ,   the UNICIT consortium, Meyaard Linde , Kuball Jürgen H. E. , Oldenburg Bas , Leusen Jeanette H. W. 
Published: July 2024

AbstractPD-1 blockade therapy has revolutionized melanoma treatment, but still not all patients benefit and pre-treatment identification of those patients is difficult. Increased expression of inflammatory markers such as interleukin (IL)-6 in blood of patients correlates with poor treatment response. We set out to study the effect of inflammatory cytokines on PD-1 blockade in vitro. For this, we studied the effect of IL-6 and type I interferon (IFN) in vitro on human T cells in a mixed leukocyte reaction (MLR) in the absence or presence of PD-1 blockade. While IL-6 reduced IFN-γ secretion by T cells in both the presence and absence of PD-1 blockade, IFN-α specifically reduced the IFN-γ secretion only in the presence of PD-1 blockade. IFN-α reduced T cell proliferation independent of PD-1 blockade and reduced the percentage of cells producing IFN-γ only in the presence of PD-1 blockade. Next we determined the type I IFN score in a cohort of 22 melanoma patients treated with nivolumab. In this cohort, we did not find a correlation between clinical response and type I IFN score, nor between clinical response and IFN-γ secretion in vitro in a MLR in the presence of PD-1 blockade. We conclude that IFN-α reduces the effectiveness of PD-1 blockade in vitro, but that in this cohort, type I IFN score in vivo, nor IFN-γ secretion in vitro in a MLR in the presence of PD-1 blockade correlated to decreased therapy responses in patients.
A retrospective observational study of ibrutinib in chronic lymphocytic leukaemia in a real-life setting in France using the national claims database (OSIRIS)
Authors: Choquet Sylvain , Marchal Clarisse , Deygas Floriane , Deslandes Marine , Macher Nahid , de Pouvourville Gérard , Levy Vincent 
Published: July 2024

Abstract
Background
Ibrutinib is a Bruton’s tyrosine kinase inhibitor indicated for the first-line treatment and relapse of chronic lymphocytic leukaemia (CLL), Waldenström’s macroglobulinemia (WM) and mantle cell lymphoma (MCL). This study aimed to describe the characteristics of CLL patients treated with ibrutinib and its effectiveness, safety, and treatment pattern in real life.

Methods
All patients covered by the general health scheme (approximately 80% of the French population) with a first ibrutinib dispensation from August 1, 2017 (date of reimbursement in France) to December 31, 2020, were identified in the French National Health Insurance database (SNDS). An algorithm was developed to identify the disease (CLL, MCL or WM) for which ibrutinib was prescribed. This article focused on CLL patients. The time to next treatment (TTNT) was plotted using Kaplan‒Meier curves.

Results
During this period, 6,083 patients initiated ibrutinib, among whom 2,771 (45.6%) patients had CLL (mean age of 74 years; 61% of men). At ibrutinib initiation, 46.6% of patients had a cardiovascular comorbidity. Most patients (91.7%) were not hospitalized during the exposure period for one of the cardiovascular or bleeding events studied. Hospitalizations were more frequent in patients with a cardiovascular comorbidity (5.9% versus 11.0%, p-value < 0.0001) and aged over 70 (5.9% versus 9.4%, p-value < 0.0001). The median TTNT was not reached.

Conclusion
This is one of the largest cohorts of ibrutinib-treated patients in the world. The profile of CLL patients treated with ibrutinib was in accordance with the marketing authorization and reimbursement. This study confirmed effectiveness and safety data.
FRACTION: protocol of a phase II study of Fedratinib and Nivolumab combination in patients with myelofibrosis and resistance or suboptimal response to JAK-inhibitor treatment of the German MPN study group (GSG-MPN)
Authors: Isfort Susanne , von Bubnoff Nikolas , Al-Ali Haifa Kathrin , Becker Heiko , Götze Thorsten , le Coutre Philipp , Griesshammer Martin , Moskwa Claudia , Wohn Luisa , Riedel Johanna , Palandri Francesca , Manz Kirsi , Hochhaus Andreas , Döhner Konstanze , Heidel Florian H. 
Published: July 2024

AbstractDevelopment of Janus-kinase (JAK) inhibitors has revolutionized the therapeutic landscape for patients with myeloproliferative neoplasia (MPN). Following approval of the first JAK1/2-inhibitor Ruxolitinib, symptoms of this inflammatory disease, characterized by splenomegaly, release of inflammatory cytokines and appearance of thrombosis, could be effectively reduced for the first time. However, JAK-inhibitor treatment is limited in several aspects: 1) duration of response: 3 years after initiation of therapy more than 50% of patients have discontinued JAK-inhibitor treatment due to lack of efficacy or resistance; 2) reduction of disease burden: while effective in reducing inflammation and constitutional symptoms, JAK-inhibitors fail to reduce the malignant clone in the majority of patients and therefore lack long-term efficacy. Early clinical trials for patients with myelofibrosis (MF) have tried to address these issues for patients with suboptimal response to Ruxolitinib therapy while combination therapies with Fedratinib are rare. Recent reports provided first evidence on how the JAK2-V617F mutated myeloid cells may influence T-cell responses. JAK2-V617F promoted the synthesis of PD-L1 in MPN cells leading to limited anti-neoplastic T-cell responses, metabolic changes in T-cells and eventually JAK2-V617F-driven immune-escape of MPN cells. These findings may facilitate the use of immunotherapeutic approaches for JAK-mutated clones. Immune checkpoints refer to a variety of inhibitory pathways that are crucial for maintaining self-tolerance and modulating the duration and amplitude of physiological immune responses in peripheral tissues in order to minimize collateral tissue damage. The FRACTION study is a single arm, open label Phase II trial investigating the combination of Fedratinib with the PD-1 inhibitor Nivolumab in patients with myelofibrosis and suboptimal or lack of response to JAK-inhibitor therapy. Over a 12 months period the trial assesses longer term outcomes, particularly the effects on clinical outcomes, such as induction of clinical remissions, quality of life and improvement of anemia. No prospective clinical trial data exist for combinations of JAK- and immune-checkpoint-inhibitors in the planned MF study population and this study will provide new findings that may contribute to advancing the treatment landscape for MF patients with suboptimal responses and limited alternatives.
Effect of sintering temperature on the structural, morphological, optical and electrical properties of Ba1 − xLaxFe12O19
Authors: Nishkala K. R. , Rao Rajat Radhakrishna , Mutalik Srinivas , Murari M. S. , Daivajna Mamatha D. 
Published: July 2024

AbstractLa substituted M-type Barium hexaferrite, Ba(1−x)La(x)Fe12O19, (x = 0.25 and 0.30) were synthesized using ball milling followed by heat treatment at 1150˚C and 1300˚C and the influence of sintering temperature as well as La doping were presented. X-ray diffraction, FESEM, dielectric spectroscopy, and ferroelectric measurements were performed to study the structural, morphological, dielectric, and ferroelectric properties of the prepared samples. Rietveld refinement on the X-ray diffraction measurement reveals the formation of a phase magnetoplumbite structure of barium hexaferrite only for the samples sintered at 1300˚C. The secondary phase, along with the major magnetoplumbite structure, was observed for the sample sintered at 1150˚C. Hexagonal plate-like grains of different sizes were observed, and samples sintered at 1300˚C showed large-size grains. Porosity was observed to decrease with La doping. Impedance spectroscopy reveals that Maxwell-Wagner-type polarisation occurs with the relaxation of mobile charges having long-range hopping. However, the ferroelectric property was suppressed for samples sintered at 1300˚C.
The generation of tetrahedral meshes for NURBS-enhanced FEM
Authors: Zou Xi , Lo Sui Bun , Sevilla Ruben , Hassan Oubay , Morgan Kenneth 
Published: July 2024

AbstractThis work presents the first method for generating tetrahedral-based volume meshes dedicated to the NURBS-enhanced finite element method (NEFEM). Built upon the developed method of generating feature-independent surface meshes tailored for NEFEM, the proposed mesh generation scheme is able to grow volume elements that inherit the feature-independence by using the surface mesh as the initial boundary discretisation. Therefore, the generated tetrahedral elements may contain triangular faces that span across multiple NURBS surfaces whilst maintaining the exact boundary description. The proposed strategy completely eliminates the need for de-featuring complex watertight CAD models. At the same time, it eliminates the uncertainty originated from the simplification of CAD models adopted in industrial practice and the error introduced by traditional isoparametric mesh generators that produce polynomial approximations of the true boundary representation. Thanks to the capability of having element faces traversing multiple geometric surfaces, small geometric features in the CAD model no longer restrict the minimum element size, and the user-required mesh spacing in the generated mesh is better satisfied than in traditional meshes that require local refinement. To demonstrate the ability of the proposed approach, a variety of CAD geometries are meshed with the proposed strategy, including examples relevant to the fluid dynamics, wave propagation and solid mechanics communities.
Analysis of clinical characteristics of mismatch repair status in colorectal cancer: a multicenter retrospective study
Authors: Mao Jing , He Yang , Chu Jian , Hu Boyang , Yao Yanjun , Yan Qiang , Han Shuwen 
Published: July 2024

Abstract
Background
Microsatellite instability (MSI) caused by DNA mismatch repair (MMR) deficiency is of great significance in the occurrence, diagnosis and treatment of colorectal cancer (CRC).

Aim
This study aimed to analyze the relationship between mismatch repair status and clinical characteristics of CRC.

Methods
The histopathological results and clinical characteristics of 2029 patients who suffered from CRC and underwent surgery at two centers from 2018 to 2020 were determined. After screening the importance of clinical characteristics through machine learning algorithms, the patients were divided into deficient mismatch repair (dMMR) and proficient mismatch repair (pMMR) groups based on the immunohistochemistry results and the clinical feature data between the two groups were observed by statistical methods.

Results
The dMMR and pMMR groups had significant differences in histologic type, TNM stage, maximum tumor diameter, lymph node metastasis, differentiation grade, gross appearance, and vascular invasion. There were significant differences between the MLH1 groups in age, histologic type, TNM stage, lymph node metastasis, tumor location, and depth of invasion. The MSH2 groups were significantly different in age. The MSH6 groups had significant differences in age, histologic type, and TNM stage. There were significant differences between the PMS2 groups in lymph node metastasis and tumor location. CRC was dominated by MLH1 and PMS2 combined expression loss (41.77%). There was a positive correlation between MLH1 and MSH2 and between MSH6 and PMS2 as well.

Conclusions
The proportion of mucinous adenocarcinoma, protruding type, and poor differentiation is relatively high in dMMR CRCs, but lymph node metastasis is rare. It is worth noting that the expression of MMR protein has different prognostic significance in different stages of CRC disease.
Quantum mechanics, radiation, and the equivalence proof
Authors: Blum Alexander , Jähnert Martin 
Published: July 2024

AbstractThis paper re-evaluates the formative year of quantum mechanics—from Heisenberg’s first paper on matrix mechanics to Schrödinger’s equivalence proof—by focusing on the role of radiation in the emerging theory. We argue that the radiation problem played a key role in early quantum mechanics, a role that has not been taken into account in the standard histories. Radiation was perceived by the main protagonists of matrix and wave mechanics as a central lacuna in these emerging theories and continued to contribute to the theoretical development and conceptual clarification of quantum mechanics. Studying the interplay between quantum mechanics and radiation, the paper provides an account of (a) how quantum mechanics was able to connect to its empirical basis in spectroscopy and (b) how Schrödinger’s equivalence proof emerged from his explorative calculations on the emission of radiation.
The effect of ileal resection length on postoperative complications and prognosis in right colon cancer
Authors: Yıldırım Murat , Kocabay Asım , Koca Bulent , Saglam Ali Ihsan , Ozkan Namık 
Published: July 2024

Abstract
Background
There is a lack of literature on the length of the terminal ileum to be resected in right hemicolectomy for colon cancer. Therefore, we aimed to determine the mean ileal loop length and the effect of this variation on postoperative complications and long-term oncological outcomes in patients who underwent right hemicolectomy.

Methods
Right hemicolectomy surgeries performed for colon cancer in a tertiary care hospital between January 2011 and December 2018 were retrospectively analyzed from a prospective database. Two patient groups were established based on the mean length of the resected ileum above and below 7 cm. The two groups were compared for clinicopathological data, postoperative complications, mortality, long-term overall survival (OS) and disease-free survival (DFS). The factors contributing to OS and DFS were analyzed.

Results
The study included 217 patients. Body mass index (BMI) values were significantly higher in the ileum resection length > 7 cm group (p = 0.009). Pathological N stage, tumor diameter, and number of metastatic lymph nodes were significantly higher in the ileum resection length > 7 cm group (p = 0.001, p = 0.001, and p = 0.026, respectively). There was no significant difference for postoperative complication and mortality rates between the two groups. The mean follow-up period was 61.2 months (2-120) in all patients. The total number of deaths was 29 (11.7%) while the 60-month OS was 83.5% and 50-month DFS was 81.8%. There was no significant difference between the groups in terms of OS and DFS rates (p > 0.05).

Conclusions
Excessive resection of the distal ileum in right hemicolectomy does not provide any benefit in terms of prognosis and complications.The ileum resection length and values close to it in our study appear to be sufficient.
Real-time analgesic efficacy and factors determining drug requirements of combined spinal-epidural analgesia for labor: a prospective cohort study
Authors: Wu Shuzhen , Lu Yaxin , Zhang Zijing , Zhong Linjia , Dai Hongfei , Fang Changping , Huang Minli , Liu Zifeng , Wu Lingling 
Published: July 2024

Abstract
Purpose
Combined spinal-epidural analgesia (CSEA) is effective but not sufficient for labor pain. This study was conducted to assess the real-time analgesic efficacy, side effects of anesthetic drug dosage, and maternal satisfaction in labor to provide reference for the optimization of labor analgesia.

Methods
This was a prospective, cohort, single-center study that included 3020 women who received CSEA for labor analgesia. The visual analogue scale (VAS) for labor pain, real-time anesthetic drug dosage, side effects, adverse labor outcomes, factors influencing average drug dosage, and maternal satisfaction with CSEA were assessed.

Results
Overall, the VAS labor pain score was lowest at the first hour after the anesthesia was given. After 4 h for primiparas and 3 h for multiparas, the VAS score was greater than 3 but the anesthetic drug dosage did not reach the maximum allowed dosage at the same time. The average anesthetic drug dosage was positively correlated with fever, urinary retention, uterine atony, prolonged active phase, prolonged second stage, assisted vaginal delivery, and postpartum hemorrhage. The average anesthetic drug dosage was the highest in women ≤ 20 years old, those with a body mass index (BMI) ≥ 24.9 kg/m2, and those with a primary or secondary education level.

Conclusion
Appropriate age guidance and emphasis on education of labor analgesia, weight management during pregnancy, and real-time anesthetic dosage adjustment during labor based on VAS pain score may have positive effects on the satisfaction of labor analgesia.

Clinical trial number and registry
Clinicaltrials.gov (ChiCTR2100051809).
Nipple reconstruction using spiral-peeling technique during oncoplastic breast-conserving surgery for a patient with small breasts
Authors: Kijima Yuko , Hirata Munetsugu , Higo Naotomo , Nakazawa Yumika , Shinmura Kazuya 
Published: July 2024

Abstract
Treatment of early breast cancer using breast-conserving surgery (BCS) commonly leads to local control and acceptable cosmetic results. We report a useful technique to achieve symmetry of the breast shape and nipple-areola, with excellent results. A Japanese patient with early breast cancer located in the inner central area of the breast was enrolled in this study. Intraductal spread of breast cancer to the nipple was suspected; however, no invasion was observed outside the nipple wall. We preserved the cylindrical surface, but resected the inner tissue with the top surface of the nipple. After coring the nipple, the remnant cylindrical surface was cut into a spiral shape. Nipple reconstruction using the spiral-peeling technique during oncoplastic breast-conserving surgery (OPBCS) may be useful for patients who desire nipple preservation.
A snowfall climatology of the Ohio River Valley, USA
Authors: Suriano Zachary J. , Guercio Harmony L. 
Published: July 2024

AbstractSnowfall in the Ohio River Valley, USA, presents a relatively unique challenge due to the large gradient of event frequency and magnitude, and subsequent levels of preparation within local communities. Even relatively small magnitude events can cause widespread impacts due to available infrastructure. Here we present a climatology of snowfall conditions and events over a 74-year period using a network of daily observational stations across the region. Snowfall totals and event frequencies both exhibit a southwest to northeast gradient of increasing snowfall, where the majority of snowfall (> 80%) occurs during the core winter months of December through February. There is a clear influence of Lake Erie on snowfall conditions in the northeast corner of the domain, where snowfall frequency, totals, and trends are substantially higher within the lake belt relative to areas further inland. Over time, snowfall significantly increased downwind of Lake Erie by as much as 42%, while significant decreases of over 55% occurred in central Tennessee and eastern Ohio. Intra-seasonally, snowfall totals trended significantly less during November and March for much of the domain, suggesting a compression of the snowfall season to more core winter months. Trends in snowfall frequency were apparent for many sub-regions, however evidence here suggests the trends in snowfall totals were primarily driven by trends in snowfall magnitude per event.