bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental demonstration of high fidelity entanglement distribution over decoherence channels via qubit transduction
Authors: Lim Hyang-Tag , Hong Kang-Hee , Kim Yoon-Ho 
Published: October 2015

AbstractQuantum coherence and entanglement, which are essential resources for quantum information, are often degraded and lost due to decoherence. Here, we report a proof-of-principle experimental demonstration of high fidelity entanglement distribution over decoherence channels via qubit transduction. By unitarily switching the initial qubit encoding to another, which is insensitive to particular forms of decoherence, we have demonstrated that it is possible to avoid the effect of decoherence completely. In particular, we demonstrate high-fidelity distribution of photonic polarization entanglement over quantum channels with two types of decoherence, amplitude damping and polarization-mode dispersion, via qubit transduction between polarization qubits and dual-rail qubits. These results represent a significant breakthrough in quantum communication over decoherence channels as the protocol is input-state independent, requires no ancillary photons and symmetries and has near-unity success probability.
Fast and intense green emission of Tb3+ in borosilicate glass modified by Cu+
Authors: Xia Fanshu , Liu Siyuan , Wang Yang , Mao Jiayi , Li Xinxi , Wang Yiqun , Chen Guorong 
Published: October 2015

AbstractWe present photoluminescence properties of Tb3+doped borosilicate glasses modified by Cu+. Around 5-time enhanced emission at 541 nm due to the superposed emission of Tb3+and Cu+is observed under the deep UV excitation. Excitation spectra demonstrate a greatly increased absorption of Tb3+ions in the deep UV region towards the Cu+excitation band, while the shortened Cu+emission lifetime of glasses in association with presence of Tb3+ions implies an energy transfer process from Cu+to Tb3+ions. Meanwhile, the Tb3+emission lifetime is significantly shortened from the conventional millisecond level (~4 ms) to the microsecond regime up to around 90 μs. This most likely starts with the role of Cu+as a co-activator by initiating the d-f orbital hybridization process via an interaction with Tb3+, thus relaxing the spin forbidden transition of Tb3+ions to the partially allowed one. Moreover, combination of emissions from Cu+and Tb3+ions generates a composite green emission with adjustable CIE (Commission Internationale de L’Eclairage) chromaticity coordinates achievable by co-doping Cu+/Tb3+in the different ratio and/or altering the excitation wavelength from deep UV to near UV region.
Synergistic Effect of Sorafenib and Radiation on Human Oral Carcinoma in vivo
Authors: Hsu Fei-Ting , Chang Betty , Chen John Chun-Hao , Chiang I-Tsang , Liu Yu-Chang , Kwang Wei-Kang , Hwang Jeng-Jong 
Published: October 2015

AbstractOral squamous cell carcinoma often causes bone invasion resulting in poor prognosis and affects the quality of life for patients. Herein, we combined radiation with sorafenib, to evaluate the combination effect on tumor progression and bone erosion in an in situ human OSCC-bearing mouse model. Treatment procedure were arranged as following groups: (a) normal (no tumor); (b) control (with tumor); (c) sorafenib (10 mg/kg/day); (d) radiation (single dose of 6 Gy); (e) pretreatment (sorafenib treatment for 3 days prior to radiation) and (f) concurrent treatment (sorafenib and radiation on the same day). The inhibition of tumor growth and expression level of p65 of NF-κB in tumor tissues were the most significant in the pretreatment group. EMSA and Western blot showed that DNA/NF-κB activity and the expressions of NF-κB-associated proteins were down-regulated. Notably, little to no damage in mandibles and zygomas of mice treated with combination of sorafenib and radiation was found by micro-CT imaging. In conclusion, sorafenib combined with radiation suppresses radiation-induced NF-κB activity and its downstream proteins, which contribute to radioresistance and tumorigenesis. Additionally, bone destruction is also diminished, suggesting that combination treatment could be a potential strategy against human OSCC.
An auto-adaptive optimization approach for targeting nonpoint source pollution control practices
Authors: Chen Lei , Wei Guoyuan , Shen Zhenyao 
Published: October 2015

AbstractTo solve computationally intensive and technically complex control of nonpoint source pollution, the traditional genetic algorithm was modified into an auto-adaptive pattern and a new framework was proposed by integrating this new algorithm with a watershed model and an economic module. Although conceptually simple and comprehensive, the proposed algorithm would search automatically for those Pareto-optimality solutions without a complex calibration of optimization parameters. The model was applied in a case study in a typical watershed of the Three Gorges Reservoir area, China. The results indicated that the evolutionary process of optimization was improved due to the incorporation of auto-adaptive parameters. In addition, the proposed algorithm outperformed the state-of-the-art existing algorithms in terms of convergence ability and computational efficiency. At the same cost level, solutions with greater pollutant reductions could be identified. From a scientific viewpoint, the proposed algorithm could be extended to other watersheds to provide cost-effective configurations of BMPs.
Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling
Authors: Medzikovic Lejla , Schumacher Cees A. , Verkerk Arie O. , van Deel Elza D. , Wolswinkel Rianne , van der Made Ingeborg , Bleeker Natascha , Cakici Daniella , van den Hoogenhof Maarten M. G. , Meggouh Farid , Creemers Esther E. , Remme Carol Ann , Baartscheer Antonius , de Winter Robbert J. , de Vries Carlie J. M. , Arkenbout E. Karin , de Waard Vivian 
Published: October 2015

AbstractDistinct stressors may induce heart failure. As compensation, β-adrenergic stimulation enhances myocardial contractility by elevating cardiomyocyte intracellular Ca2+ ([Ca2+]i). However, chronic β-adrenergic stimulation promotes adverse cardiac remodelling. Cardiac expression of nuclear receptor Nur77 is enhanced by β-adrenergic stimulation, but its role in cardiac remodelling is still unclear. We show high and rapid Nur77 upregulation in cardiomyocytes stimulated with β-adrenergic agonist isoproterenol. Nur77 knockdown in culture resulted in hypertrophic cardiomyocytes. Ventricular cardiomyocytes from Nur77-deficient (Nur77-KO) mice exhibited elevated diastolic and systolic [Ca2+]i and prolonged action potentials compared to wild type (WT). In vivo, these differences resulted in larger cardiomyocytes, increased expression of hypertrophic genes and more cardiac fibrosis in Nur77-KO mice upon chronic isoproterenol stimulation. In line with the observed elevated [Ca2+]i, Ca2+-activated phosphatase calcineurin was more active in Nur77-KO mice compared to WT. In contrast, after cardiac pressure overload by aortic constriction, Nur77-KO mice exhibited attenuated remodelling compared to WT. Concluding, Nur77-deficiency results in significantly altered cardiac Ca2+ homeostasis and distinct remodelling outcome depending on the type of insult. Detailed knowledge on the role of Nur77 in maintaining cardiomyocyte Ca2+ homeostasis and the dual role Nur77 plays in cardiac remodelling will aid in developing personalized therapies against heart failure.
In vivo sub-femtoliter resolution photoacoustic microscopy with higher frame rates
Authors: Lee Szu-Yu , Lai Yu-Hung , Huang Kai-Chih , Cheng Yu-Hsiang , Tseng Tzu-Fang , Sun Chi-Kuang 
Published: October 2015

AbstractMicroscopy based on non-fluorescent absorption dye staining is widely used in various fields of biomedicine for 400 years. Unlike its fluorescent counterpart, non-fluorescent absorption microscopy lacks proper methodologies to realize its in vivo applications with a sub-femtoliter 3D resolution. Regardless of the most advanced high-resolution photoacoustic microscopy, sub-femtoliter spatial resolution is still unattainable and the imaging speed is relatively slow. In this paper, based on the two-photon photoacoustic mechanism, we demonstrated a in vivo label free laser-scanning photoacoustic imaging modality featuring high frame rates and sub-femtoliter 3D resolution simultaneously, which stands as a perfect solution to 3D high resolution non-fluorescent absorption microscopy. Furthermore, we first demonstrated in vivo label-free two-photon acoustic microscopy on the observation of non-fluorescent melanin distribution within mouse skin.
MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition
Authors: Zhang Yuan , Wang Yu , Wei Yifang , Li Mengyang , Yu Shentong , Ye Mingxiang , Zhang Hongmei , Chen Suning , Liu Wenchao , Zhang Jian 
Published: October 2015

AbstractDocetaxel is commonly used as an effective chemotherapeutic agent in breast cancer treatment, but the underlying mechanisms of drug resistance are not fully understood. The purpose of this study was to investigate the possible role of miR-129-3p in breast cancer cell resistance to docetaxel. MiR-129 and miR-129-3p inhibitor were transfected into breast cancer cells to investigate their effects on chemoresistance to docetaxel. The function of miR-129-3p was evaluated by apoptosis, cell proliferation and cell cycle assays. We found that miR-129-3p was up-regulated in MDA-MB-231/Doc cells, concurrent with CP110 down-regulation, compared to the parental MDA-MB-231 cells. In vitro drug sensitivity assays demonstrated that miR-129-3p inhibition sensitized MDA-MB-231/Doc and MCF-7 cells to docetaxel, whereas miR-129 overexpression enhanced MDA-MB-231 and MCF-7 cell resistance to docetaxel. Ectopic miR-129 expression reduced CP110 expression and the luciferase activity of a CP110 3′ untranslated region-based reporter construct in MDA-MB-231 cells, suggesting that CP110 is a direct miR-129-3p target. We demonstrated that restoration of CP110 expression in MDA-MB-231 and MCF-7 cells by miR-129 overexpression rendered the cells sensitive to docetaxel. In a nude xenograft model, miR-129 up-regulation significantly decreased MDA-MB-231 cells’ response to docetaxel. Our findings suggest that miR-129-3p down-regulation potentially sensitizes breast cancer cells to docetaxel treatment.
Simultaneous shaping of amplitude and phase of light in the entire output plane with a phase-only hologram
Authors: Wu Liang , Cheng Shubo , Tao Shaohua 
Published: October 2015

AbstractAn iterative beam shaping algorithm is proposed to simultaneously shape the amplitude and phase of an optical beam. The proposed algorithm consists of one input plane and two completely overlapped output planes which refer to the output plane in real space. The two output planes are imposed with both amplitude and phase constraints and the constrained areas in the two output planes are complementary. As a result, both the amplitude and phase in the entire output plane are controllable and arbitrary target complex amplitudes can be achieved with the proposed algorithm. The computing result of the proposed algorithm is a phase-only distribution which can be conveniently realized with a spatial light modulator or a fabricated diffractive optical element. Both simulations and experiments have verified the high performance of the proposed algorithm.
Adhesion of voids to bimetal interfaces with non-uniform energies
Authors: Zheng Shijian , Shao Shuai , Zhang Jian , Wang Yongqiang , Demkowicz Michael J. , Beyerlein Irene J. , Mara Nathan A. 
Published: October 2015

AbstractInterface engineering has become an important strategy for designing radiation-resistant materials. Critical to its success is fundamental understanding of the interactions between interfaces and radiation-induced defects, such as voids. Using transmission electron microscopy, here we report an interesting phenomenon in their interaction, wherein voids adhere to only one side of the bimetal interfaces rather than overlapping them. We show that this asymmetrical void-interface interaction is a consequence of differing surface energies of the two metals and non-uniformity in their interface formation energy. Specifically, voids grow within the phase of lower surface energy and wet only the high-interface energy regions. Furthermore, because this outcome cannot be accounted for by wetting of interfaces with uniform internal energy, our report provides experimental evidence that bimetal interfaces contain non-uniform internal energy distributions. This work also indicates that to design irradiation-resistant materials, we can avoid void-interface overlap via tuning the configurations of interfaces.
Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis
Authors: Woo Seo Dong , Yeop You Seung , Chung Woo-Jae , Cho Dong-Hyung , Kim Jae-Sung , Su Oh Jeong 
Published: October 2015

AbstractThe key step for faithful chromosome segregation during meiosis is kinetochore assembly. Defects in this process result in aneuploidy, leading to miscarriages, infertility and various birth defects. However, the roles of kinetochores in homologous chromosome segregation during meiosis are ill-defined. Here we found that Zwint-1 is required for homologous chromosome segregation during meiosis. Knockdown of Zwint-1 accelerated the first meiosis by abrogating the kinetochore recruitment of Mad2, leading to chromosome misalignment and a high incidence of aneuploidy. Although Zwint-1 knockdown did not affect Aurora C kinase activity, the meiotic defects following Zwint-1 knockdown were similar to those observed with ZM447439 treatment. Importantly, the chromosome misalignment following Aurora C kinase inhibition was not restored after removing the inhibitor in Zwint-1-knockdown oocytes, whereas the defect was rescued after the inhibitor washout in the control oocytes. These results suggest that Aurora C kinase-mediated correction of erroneous kinetochore-microtubule attachment is primarily regulated by Zwint-1. Our results provide the first evidence that Zwint-1 is required to correct erroneous kinetochore-microtubule attachment and regulate spindle checkpoint function during meiosis.
Comparison of transmission of Papaya leaf curl China virus among four cryptic species of the whitefly Bemisia tabaci complex
Authors: Guo Tao , Guo Qi , Cui Xi-Yun , Liu Yin-Quan , Hu Jian , Liu Shu-Sheng 
Published: October 2015

AbstractBegomoviruses are transmitted by cryptic species of the whitefly Bemisia tabaci complex, often in a species-specific manner. Papaya leaf curl China virus (PaLCuCNV) has been recorded to infect several crops including papaya, tomato and tobacco in China. To help assess the risks of spread of this virus, we compared the acquisition, retention and transmission of PaLCuCNV among four species of whiteflies, Middle East-Asia Minor 1 (MEAM1), Mediterranean (MED), Asia 1 and Asia II 7. All four species of whiteflies are able to acquire, retain and transmit the virus, but with different levels of efficiency. Transmission tests using tomato as the host plant showed that MEAM1 transmitted PaLCuCNV with substantially higher efficiency than did MED, Asia 1 and Asia II 7. Furthermore, accumulation of PaLCuCNV in the whiteflies was positively associated with its efficiency of transmitting the virus. Altogether, these findings indicate that MEAM1 is the most efficient vector for PaLCuCNV in the four species of whiteflies and suggest that risks of PaLCuCNV pandemics are high in regions where MEAM1 occurs.
Topotecan for Relapsed Small-cell Lung Cancer: Systematic Review and Meta-Analysis of 1347 Patients
Authors: Horita Nobuyuki , Yamamoto Masaki , Sato Takashi , Tsukahara Toshinori , Nagakura Hideyuki , Tashiro Ken , Shibata Yuji , Watanabe Hiroki , Nagai Kenjiro , Inoue Miyo , Nakashima Kentaro , Ushio Ryota , Shinkai Masaharu , Kudo Makoto , Kaneko Takeshi 
Published: October 2015

AbstractTopotecan is the most reliable chemotherapy regimen for relapsed small-cell lung carcinoma (SCLC). The efficacy and adverse effects of topotecan as reported by previous studies varied greatly. The inclusion criterion was a prospective study that was able to provide data for 6-month over-all survival (OS) rate, 1-year OS rate, objective responses, and/or adverse effects of single agent topotecan as a second line chemotherapy for SCLC, written in English language as a full article. Any topotecan regimen were allowed. Binary data were meta-analyzed with the random-model generic inverse variance method. We included 14 articles consisted of 1347 patients. Pooled values were estimated as follows. <Refractory relapse> Six-month OS rate: 37% (95% CI: 28–46%). One-year OS rate: 9% (95% CI: 5–13%). Response rate: 5% (95% CI: 1–8%). <Sensitive relapse> Six-month OS rate: 57% (95% CI: 50–64%). One-year OS rate: 27% (95% CI: 22–32%). Response rate: 17% (95% CI: 11–23%). <Adverse effect> Grade III/IV neutropenia 69% (95% CI: 58–80%). Grade III/IV thrombopenia 41% (95% CI: 34–48%). Grade III/IV anemia 24% (95% CI: 17–30%). Non-hematorogical events were rare. Chemotherapy-related death 2% (95% CI: 1–3%). In conclusion, Topotecan provided a possibly promising outcome for sensitive-relapse SCLC and poor outcome for refractory relapse SCLC. Adverse events were mainly hematological.
Sustained suppression of viral replication in improving vitamin D serum concentrations in patients with chronic hepatitis B
Authors: Chen En-Qiang , Bai Lang , Zhou Tao-You , Fe Min , Zhang Dong-Mei , Tang Hong 
Published: October 2015

AbstractRecently, the role of vitamin D in chronic hepatitis B (CHB) has attracted a lot attention. In this study, 128 naïve CHB patients (91 with positive HBeAg, 37 with negative-HBeAg) were enrolled and 128 volunteers without liver diseases were enrolled as controls. Compared to that of healthy controls, the mean level of 25(OH)D3 in CHB patients was significantly lower; and the percent of patients with sufficient 25(OH)D3 (≥20 ng/mL) was also significantly lower than that of healthy controls. Among those CHB patients, the level of 25(OH)D3 was negatively correlated with the serum HBV-DNA level. Additionally, the level of 25(OH)D3 was significantly lower in HBeAg-positive patients than that in HBeAg-negative patients. After the patients went through the long-term antiviral treatments, both the mean level of 25(OH)D3 and the percent of patients with sufficient 25(OH)D3 increased significantly. Additionally, patients who were HBeAg free after the treatment also had much higher 25(OH)D3 level than those with persistent positive HBeAg. All those data suggested that the low vitamin D serum level was dangerous for CHB patients and the level of 25(OH)D3 was highly negatively correlated with HBV-DNA levels. Effective antiviral therapy might increase the level of vitamin D in CHB patients.
Ag Nanorods Coated with Ultrathin TiO2 Shells as Stable and Recyclable SERS Substrates
Authors: Ma Lingwei , Huang Yu , Hou Mengjing , Xie Zheng , Zhang Zhengjun 
Published: October 2015

AbstractTiO2-coated Ag nanorods (Ag@TiO2 NRs) have been fabricated as multifunctional surface-enhanced Raman scattering (SERS) substrates. Uniform TiO2 shells could sufficiently protect the internal Ag NRs against oxidation and sulfuration, thus the temporal stability of SERS substrates was markedly improved. Meanwhile, due to the synergetic effect between crystalline TiO2 and Ag, the nanocomposites could clean themselves via photocatalytic degradation of the adsorbed molecules under ultraviolet irradiation and water dilution, making the SERS substrates renewable. Such Ag@TiO2 NRs were shown to serve as outstanding SERS sensors featuring high sensitivity, superior stability and recyclability.
Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations
Authors: Abdallah Abdallah M. , Hill-Cawthorne Grant A. , Otto Thomas D. , Coll Francesc , Guerra-Assunção José Afonso , Gao Ge , Naeem Raeece , Ansari Hifzur , Malas Tareq B. , Adroub Sabir A. , Verboom Theo , Ummels Roy , Zhang Huoming , Panigrahi Aswini Kumar , McNerney Ruth , Brosch Roland , Clark Taane G. , Behr Marcel A. , Bitter Wilbert , Pain Arnab 
Published: October 2015

AbstractAlthough Bacillus Calmette-Guérin (BCG) vaccines against tuberculosis have been available for more than 90 years, their effectiveness has been hindered by variable protective efficacy and a lack of lasting memory responses. One factor contributing to this variability may be the diversity of the BCG strains that are used around the world, in part from genomic changes accumulated during vaccine production and their resulting differences in gene expression. We have compared the genomes and transcriptomes of a global collection of fourteen of the most widely used BCG strains at single base-pair resolution. We have also used quantitative proteomics to identify key differences in expression of proteins across five representative BCG strains of the four tandem duplication (DU) groups. We provide a comprehensive map of single nucleotide polymorphisms (SNPs), copy number variation and insertions and deletions (indels) across fourteen BCG strains. Genome-wide SNP characterization allowed the construction of a new and robust phylogenic genealogy of BCG strains. Transcriptional and proteomic profiling revealed a metabolic remodeling in BCG strains that may be reflected by altered immunogenicity and possibly vaccine efficacy. Together, these integrated-omic data represent the most comprehensive catalogue of genetic variation across a global collection of BCG strains.
Proteomic analysis of neurons microdissected from formalin-fixed, paraffin-embedded Alzheimer’s disease brain tissue
Authors: Drummond Eleanor S , Nayak Shruti , Ueberheide Beatrix , Wisniewski Thomas 
Published: October 2015

AbstractThe vast majority of human tissue specimens are formalin-fixed, paraffin embedded (FFPE) archival samples, making this type of tissue a potential gold mine for medical research. It is now accepted that proteomics can be done using FFPE tissue and can generate similar results as snap-frozen tissue. However, the current methodology requires a large amount of starting protein, limiting the questions that can be answered in these types of proteomics studies and making cell-type specific proteomics studies difficult. Cell-type specific proteomics has the potential to greatly enhance understanding of cell functioning in both normal and disease states. Therefore, here we describe a new method that allows localized proteomics on individual cell populations isolated from FFPE tissue sections using laser capture microdissection. To demonstrate this technique we microdissected neurons from archived tissue blocks of the temporal cortex from patients with Alzheimer’s disease. Using this method we identified over 400 proteins in microdissected neurons; on average 78% that were neuronal and 50% that were associated with Alzheimer’s disease. Therefore, this technique is able to provide accurate and meaningful data and has great potential for any future study that wishes to perform localized proteomics using very small amounts of archived FFPE tissue.