bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long-range gene regulatory landscape of cerebellar granule neuron progenitors
Authors: Riegman Kimberley L. H. , George Charlotte , Whittaker Danielle E. , Ahmed Mohi U. , Yun Haiyang , Huntly Brian J. P. , Sims David , Osborne Cameron S. , Basson M. Albert 
Published: August 2024

AbstractNeuronal specification, expansion and differentiation are tightly regulated by the concerted actions of transcription and chromatin modifying factors that are recruited to regulatory elements in the genome. Tissue-specific distal regulatory elements are typically located tens to hundreds of kilobases from the gene they regulate. To identify the distal enhancers that directly regulate a gene, information on the localisation of enhancers relative to the gene promoter in the nucleus is crucial. Cerebellar granule cell progenitors (GCps) are important transit amplifying neuronal progenitors, giving rise to the most abundant neuronal cell type in the brain. Many of the key factors that regulate fundamental developmental processes in GCps have been identified. For instance, the proneural transcription factor Atoh1 is essential for GCp specification, proliferation and differentiation and the ATP-dependent chromatin remodeller CHD7 is necessary for normal GCp proliferation and differentiation. However, both these factors are recruited to distal regulatory elements and the direct regulatory relationships between these factors, the enhancers they are recruited to, and the genes they regulate in GCps remain uncharacterised. To identify active, long-range gene regulatory interactions in GCps, we used promoter capture Hi-C (pcHi-C), together with ATAC-seq and ChIP-seq data. We present a rich dataset consisting of 46,428 interactions between 22,797 putative distal regulatory regions and 12,905 protein coding gene promoters in primary mouse GCps. Using VISTA-designated hindbrain enhancers as an example, we show that 80% of these enhancers are incorrectly annotated at present and identify the genes most likely regulated directly by these enhancers. Motif enrichment analyses showed a significant enrichment of proneural transcription factor motifs in CHD7-regulated enhancers. Further analyses revealed co-localisation of Atoh1 and CHD7 at gene enhancers, suggesting a novel regulatory relationship between Atoh1 and CHD7 in controlling the expression of key genes in the GCp lineage. We used our data to identify >1,500 Atoh-regulated enhancers, controlling the expression of 577 genes in GCps, and 197 enhancers of 22 genes that appear to be co-regulated by Atoh1 and CHD7. Co-immunoprecipitation experiments showed that Atoh1 and CHD7 interacted with each other. These findings support the emerging picture of CHD7 as an important gene regulatory co-factor for lineage-specific transcription factors. The pcHi-C data is presented as a useful resource to the community for investigating the function of long-range enhancers in the cerebellar GCp lineage.
Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma
Authors: Mariniello Katia , Pittaway James F.H. , Altieri Barbara , Borges Kleiton Silva , Hadjidemetriou Irene , Ribeiro Claudio , Ruiz-Babot Gerard , Lim Jiang A. , Foster Julie , Cleaver Julie , Sosabowski Jane , Rahman Nafis , Doroszko Milena , Hantel Constanze , Sigala Sandra , Abate Andrea , Tamburello Mariangela , Kiseljak-Vassiliades Katja , Wierman Margaret , Parvanta Laila , Abdel-Aziz Tarek E. , Chung Teng-Teng , Marco Aimee Di , Palazzo Fausto , Gomez-Sanchez Celso E. , Taylor David R. , Rayner Oliver , Ronchi Cristina L. , Gaston-Massuet Carles , Sbiera Silviu , Drake William M. , Rognoni Emanuel , Kroiss Matthias , Breault David T. , Fassnacht Martin , Guasti Leonardo 
Published: August 2024

AbstractDisruption of processes involved in tissue development and homeostatic self-renewal is increasingly implicated in cancer initiation, progression, and recurrence. The adrenal cortex is a dynamic tissue that undergoes life-long turnover. Here, using genetic fate mapping and murine adrenocortical carcinoma (ACC) models, we have identified a population of adrenocortical stem cells that express delta-like non-canonical Notch ligand 1 (DLK1). These cells are active during development, near dormant postnatally but are re-expressed in ACC. In a study of over 200 human ACC samples, we have shown DLK1 expression is ubiquitous and is an independent prognostic marker of recurrence-free survival. Paradoxically, despite its progenitor role, spatial transcriptomic analysis has identified DLK1 expressing cell populations to have increased steroidogenic potential in human ACC, a finding also observed in four human and one murine ACC cell lines. Finally, the cleavable DLK1 ectodomain is measurable in patients’ serum and can discriminate between ACC and other adrenal pathologies with high sensitivity and specificity to aid in diagnosis and follow-up of ACC patients. These data demonstrate a prognostic role for DLK1 in ACC, detail its hierarchical expression in homeostasis and oncogenic transformation and propose a role for its use as a biomarker in this malignancy.Graphical abstractStatement of significanceThis study presents DLK1 as a novel biomarker in ACC with opportunities for use in the diagnosis, prognosis and longitudinal follow up of patients. DLK1, a marker of adrenocortical stem cells, is re-expressed in ACC, is measurable in patients’ serum and is associated with increased malignancy.
Cooperative mission planning based on game theory for UAVs and USVs heterogeneous system in dynamic scenario
Authors: Long Hong , Duan Haibin 
Published: August 2024

Purpose
The purpose of this paper is to present and implement a task allocation method based on game theory for reconnaissance mission planning of UAVs and USVs system.

Design/methodology/approach
In this paper, the decision-making framework via game theory of mission planning is constructed. The mission planning of UAVs–USVs is transformed into a potential game optimization problem by introducing a minimum weight vertex cover model. The modified population-based game-theoretic optimizer (MPGTO) is used to improve the efficiency of solving this complex multi-constraint assignment problem.

Findings
Several simulations are carried out to exhibit that the proposed algorithm obtains the superiority on quality and efficiency of mission planning solutions to some existing approaches.

Research limitations/implications
Several simulations are carried out to exhibit that the proposed algorithm obtains the superiority on quality and efficiency of mission planning solutions to some existing approaches.

Practical implications
The proposed framework and algorithm are expected to be applied to complex real scenarios with uncertain targets and heterogeneity.

Originality/value
The decision framework via game theory is proposed for the mission planning problem of UAVs–USVs and a MPGTO with swarm evolution, and the adaptive iteration mechanism is presented for ensuring the efficiency and quality of the solution.
The complexity of ECF investors’ peer-effect: a test of structural social influence theory by fsQCA approach
Authors: Ling Li , Peng Ling 
Published: August 2024

PurposeThis study aims to investigate the causal complexity of ECF investors’ peer effect through two different paths of structural social influence.Design/methodology/approachUsing the fuzzy-set qualitative comparative analysis (fsQCA) approach, we employ 157 samples from a Chinese ECF source to explore how peer-effect are caused by both informational and normative mechanisms.FindingsThe findings suggests that there are multiple configurations could lead to ECF investors’ high level peer-effect through both informational and normative mechanisms, and the informational mechanism' role depends on the normative mechanism, while the normative mechanism could lead to peer-effect independently.Research limitations/implicationsThe findings enrich the literature on ECF investors’ behaviors by revealing the diverse configurations resulting in investors’ peer-effect and shedding new light on investigating the decision-making driven by information asymmetry and relationship settings for individuals at a disadvantage.Originality/valueThis is the first study that investigates the multiple-driven of ECF investors’ decision-making and the importance of mutual norms in individuals' decision-making by complex network analysis approach and qualitative comparative analysis from the perspective of complexity. The results reveal the complexity of investors’ decision-making in ECF.
Sustainability as guiding principle of communicative action the transformative and transformational potential of corporate sustainability communication as niche construction, a case from the energy sector
Authors: Weder Franzisca 
Published: August 2024

PurposeThis paper expands on existing analyses of corporate energy and sustainability communication and shows the potential of evolutionary theory to study and conceptualize sustainable corporate communication as niche construction and its transformative and transformational potential.Design/methodology/approachWith a qualitative content analysis of non-financial reporting of energy corporations and a deep dive into one selected case (Yin, 2013) with a two-step categorization of the sustainability related text and (n = 5) expert interviews (QCAmap, Mayring, 2019; Fenzl and Mayring, 2017), the paper reflects on alterations within the organization and in the organization–stakeholder relationships through corporate sustainability communication.FindingsThe analytical deep dive into one case of corporate sustainability communication of a multinational energy corporation shows the difference between a transformative and transformational character of corporate communication. The insights from the interviews support the assumption that corporates not only adapt to changes of environmental factors (perturbative communication) but also – however rarely – alter their spatiotemporal relationships with their external environment (relocational communication), so there is a lack of actual transformational communication.Originality/valueCorporates in the (renewable) energy sector as well as industry networks like gas (infrastructure) suppliers have the potential to impact their environment (stakeholder, energy communities, etc.), change cultural patterns and norms and co-construct new socio-ecological niches through communication. The study presented gives evidence and examples for transformative corporate sustainability communication. On a conceptual level, it offers an innovative framework to understand sustainability as a guiding principle for corporate communication that will stimulate corporate communication research in the future.
Novel airfoil for improved supersonic aerodynamic performance
Authors: Manaa Zeyad M. , Qasem Naef A.A. 
Published: August 2024

Purpose
This study aims to validate the linear flow theory with computational fluid dynamics (CFD) simulations and to propose a novel shape for the airfoil that will improve supersonic aerodynamic performance compared to the National Advisory Committee for Aeronautics (NACA) 64a210 airfoil.

Design/methodology/approach
To design the new airfoil shape, this study uses a convex optimization approach to obtain a global optimal shape for an airfoil. First, modeling is conducted using linear flow theory, and then numerical verification is done by CFD simulations using ANSYS Fluent. The optimization process ensures that the new airfoil maintains the same cross-sectional area and thickness as the NACA 64a210 airfoil. This study found that an efficient way to obtain the ideal airfoil shape is by using linear flow theory, and the numerical simulations supported the assumptions inherent in the linear flow theory.

Findings
This study’s findings show notable improvements (from 4% to 200%) in the aerodynamic performance of the airfoil, especially in the supersonic range, which points to the suggested airfoil as a potential option for several fighter aircraft. Under various supersonic conditions, the optimized airfoil exhibits improved lift-over-drag ratios, leading to improved flight performance and lower fuel consumption.

Research limitations/implications
This study was conducted mainly for supersonic flow, whereas the subsonic flow is tested for a Mach number of 0.7. This study would be extended for both subsonic and supersonic flights.

Practical implications
Convex optimization and linear flow theory are combined in this work to create an airfoil that performs better in supersonic conditions than the NACA 64a210. By closely matching the CFD results, the linear flow theory's robustness is confirmed. This means that the initial design phase no longer requires extensive CFD simulations, and the linear flow theory can be used quickly and efficiently to obtain optimal airfoil shapes.

Social implications
The proposed airfoil can be used in different fighter aircraft to enhance performance and reduce fuel consumption. Thus, lower carbon emission is expected.

Originality/value
The unique aspect of this work is how convex optimization and linear flow theory were combined to create an airfoil that performs better in supersonic conditions than the NACA 64a210. Comprehensive CFD simulations were used for validation, highlighting the optimization approach's strength and usefulness in aerospace engineering.
Sociodemographic and institutional factors as determinants of access to food among rural households during COVID-19 pandemic in India
Authors: Ali Jabir , Khan Waseem 
Published: August 2024

Purpose
This paper aims to analyze the nature, magnitude and determinants of access to food among rural households in India during the COVID-19 pandemic.

Design/methodology/approach
The study is based on the World Bank’s Rural Impact Survey, which has documented the shocks of COVID-19 among 2,787 rural households across six states in India. The chi-square test and binary logistics regression have been used to analyze the data.

Findings
About 49.7 % of rural households have reported the incidence of food inaccessibility and shortage, and the majority of them reported a reduction in food intake during the COVID-19 outbreak. However, the magnitude of food accessibility varied across the states and the sociodemographic characteristics of the households. Furthermore, regression analysis indicates that family size, social category and occupation as sociodemographic variables and membership in self-help groups, wage employment under Mahatma Gandhi National Rural Employment Guarantee Act and Cash transfer under Pradhan Mantri Kisan Samman Nidhi and Pradhan Mantri Garib Kalyan Yojana as institutional support factors have a significant effect on access to food among rural households.

Practical implications
The findings of the study have far-reaching policy implications for developing an effective food distribution system in crisis situations like the COVID-19 outbreak. The study also provides directions for extending the research on determinants of access to food during crisis.

Originality/value
The study is based on a large survey data from the rural households in India and provides empirical evidence on access to food faced by rural communities during the COVID-19 lockdown.
The growth of FinTech and blockchain technology in developing countries: UAE’s evidence
Authors: Al-Qudah Anas Ali , Al-Okaily Manaf , Yadav Miklesh Prasad Prasad 
Published: August 2024

Purpose
The purpose of this study is to investigate the continuous intention to use blockchain and FinTech innovations, focusing on the direct impact of user trust and perceived risks. It seeks to test how information technology (IT) quality directly affects user-perceived risk and trust and to identify how IT quality can influence FinTech continuance intentions. By examining these relationships, the study provides insights into how improvements in IT quality can mitigate perceived risks and enhance user trust, ultimately fostering sustained use of FinTech and blockchain technologies.

Design/methodology/approach
To achieve the purpose of this study, the model and hypotheses were examined based on the partial least squares structural equation modeling (PLS-SEM).

Findings
Results revealed that perceived risk is negatively impacted by system quality, while trust is positively impacted by information quality, and the most significant result in the study is continuous-use intention and uncertainty both are impacted by service quality. Also, the study used some control variables, and two of them (i.e. FinTech type and education) showed a positive significant relationship with continuance-use intention.

Practical implications
This study identifies several causal relationships between the continuance-use intention of blockchain and FinTech innovations and various factors, which can provide valuable insights for managers, enabling them to formulate appropriate strategies to foster sustainable growth in FinTech and blockchain. By leveraging these findings, managers can enhance IT quality, reduce perceived risks and build user trust, thereby promoting the ongoing adoption and success of blockchain and FinTech innovations.

Originality/value
The outcomes obtained will help both FinTech providers and researchers elucidate and understand the situation of users’ concerns about the unexpected risks/uncertainty in FinTech transactions can be mitigated through providing a high level of quality IT service and systems. Two main strategies can be merged to be used by FinTech providers/managers, first: trust building, second: risk-mitigating, both strategies can be used in the light of IT innovation and its aspects to meet the sustainable growth of FinTech.
Local community's engagement and enactment of social value from hydropower infrastructure
Authors: Caron Marie-Andrée , Drouin Nathalie , Ben Abdallah Skander , Radu Camélia 
Published: August 2024

PurposeSocial needs of local community are highly essential in the context of public infrastructure and have an impact on their performance. This paper explores the local community subjectivity in interaction with primary stakeholders to deepen our understanding of social value and this category of misunderstood stakeholders.Design/methodology/approachThe paper presents a partnership framework that aims to help stakeholders be reflexive and construct knowledge about social value of the infrastructure. The empirical material includes an extensive review of the public infrastructure documents published between 1981 and 2021 and 13 interviews with key members of local community.FindingsThe main contribution of this study is an integrated model to study the social value of an infrastructure and a dynamic approach to study how a local community engages and enacts social value. The dynamic approach highlights three plans of stakeholder’s subjectivity, which are relational, representational and operational plans to promote inclusive stakeholder’s management (“of” and “for”).Originality/valueThe study combines an analytical and a theoretical framework to investigate the enactment of social value.
Examining the moderating role of technological resources on marketing innovation and family business sustainability
Authors: Affran Samuel , Oppong Emma Doreen Otiwaa , Kolug Joseph Yenabil 
Published: August 2024

PurposeFamily businesses are on the rise and facing severe sustainability challenges. The overall purpose of this thesis is to examine the moderating role of technological resources in the relationship between marketing innovation and family business sustainability.Design/methodology/approachFrom a post-positivist perspective, this study utilized a quantitative approach and causal research design. 204 family businesses within the Accra Metropolitan Assembly were sampled for this study. Structural Equation Modeling (SMART PLS 4) was utilized for data analysis after a closed-ended questionnaire was used to gather data.FindingsIt was evidenced that marketing innovation has a positive significant effect on family business sustainability. Technological resources have a negative significant moderating effect on the relationship between marketing innovation and family business sustainability.Originality/valueThe originality of this study lies in examining the moderating effect of technological resources on the relationship between marketing innovation and family business sustainability in Ghana, where this phenomenon is less explored.
Understanding the shift: contextual determinants of classic and alternative servitisation trajectories
Authors: Bagni Gustavo , Godinho Filho Moacir 
Published: August 2024

Purpose
While servitization has been recognised for its potential to augment organizational revenue and fortify competitive advantage, the exploration of alternative servitization trajectories to the classical servitization model has been little explored in literature. Recent literature introduces the “service paradox” and presents different trajectories to the classical model, but it does not explain why a company chooses one trajectory instead of another. Therefore, this study aims to provide a model that, based on the contextual factors present, recommends which servitization trajectory the company should choose.

Design/methodology/approach
This study uses a combination of design science research (DSR) and context, intervention, mechanisms and outcomes (CIMO) to propose the model. An initial contextual factors list was created based on the literature, refined by the company’s employees and evaluated in three selected initiatives in the focal company. Furthermore, based on the understanding of the CIMO logic elements, four design propositions were elaborated to summarize the main findings of the study.

Findings
The study has demonstrated that the choice of a servitisation trajectory is intricately tied to a multitude of contextual factors, prompting organisations to deviate from conventional models towards alternative paths. Furthermore, the research sheds light on the underlying mechanisms and contextual drivers that shape servitisation decisions within the context of a consumer goods manufacturer. The analysis underscores the pivotal role of market dynamics and strategic adaptability in shaping servitisation strategies, underscoring the importance of customized approaches that cater to the distinct circumstances of each organisations.

Originality/value
The research contributes to both theory and practice by offering profound insights into the complex nature of servitisation, advocating for continuous adaptation and strategic alignment with market demands. For practitioners and decision-makers, the study provides valuable guidance on enhancing service offerings and navigating the complexities of servitisation within specific sectors, fostering a culture of learning and adaptation to drive sustainable growth.