bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pembentukan Karakter Anak Usia Remaja Dalam Keluarga Muslim Di Desa Sondosia Kecamatan Bolo Kabupaten Bima
Authors: Rahmawati Auliah , Ani Wafiroh  
Published: August 2024

Penelitian ini merupakan hasil dari penelitian lapangan dengan latar belakang adanya pergaulan bebas yang dilakukan oleh sebagian remaja di Desa Sondosia dimana orangtua kurang peduli dengan pola asuh yang harus diterapkan serta kurang mengontrol dan membiarkan pergaulannya sehingga anak terlibat dalam pergaulan yang menyimpang.
Penelitian ini bertujuan untuk mengetahui upaya orang tua dalam pembentukan karakter anak usia remaja yang dimana di Desa tersebut adalah mayoritas muslim. Lokasi penelitian ini bertempat di Desa Sondosia Kecamatan Bolo Kabupaten Bima. Jenis penelitian yang digunakan yaitu kualitatif dengan menggunakan pendekatan empiris. Dalam pengumpulan data tekhnik yang digunakan ialah observasi nonpartisipatif, wawancara semiterstruktur, dan dokumentasi. Sedangkan analisis data menggunakan reduksi data, penyajian data, dan kesimpulan.

Hasil penelitian menyimpulkan bahwa: Pertama kehidupan anak usia remaja di Desa Sondosia
Kecamatan Bolo Kabupaten Bima dapat dikatakan kurang baik karena masih ada ditemuinya pergaulan negatif yang ditemui pada sebagian remaja di Desa Sondosia seperti penggunaan tramadol, merokok di usia dini, tawuran remaja, bolos sekolah, berkata kasar dan tidak sopan terhadap orang tua, tidak ta’at, keluturan tengah malam serta jarang beribadah karena kurangnya kontrol dan pengawasan dari orang tua. Walaupun masih ada ditemui remaja yang memiliki sikap dan sifat teladan dan terpuji seperti memiliki sopan santun, rajin beribadah dan lain sebagainya. Kedua, upaya orang tua dalam pembentukan karakter anak usia remaja dengan menggunakan pola asuh yang yaitu pola asuh permisif, demokratis dan otoriter
Fifteen-Year Results of a Comparative Analysis of Tendon Repair Versus Physiotherapy for Small-to-Medium-Sized Rotator Cuff Tears
Authors: Moosmayer S. , Lund G. , Seljom U. Sire , Haldorsen B. , Svege I.C. , Hennig T. , Pripp A.H. , Smith H.J. 
Published: August 2024

Abstract:
The optimal treatment for small-to-medium-sized rotator cuff tears remains a topic of debate. While both tendon repair and physiotherapy have shown comparable short-term results, there are concerns about the long-term effectiveness of physiotherapy. In 2 previous reports presenting the 5 and 10-year results of this trial, significant and increasing differences were observed in favor of tendon repair. Further investigation of the unexplored time interval after 10 years is essential to fully understand the implications of our treatment approaches. A total of 103 patients with a full-thickness rotator cuff tear not exceeding 3 cm were randomly allocated to tendon repair or physiotherapy with optional secondary repair. Measurements of shoulder function were performed by a blinded assessor at 6 months and 1, 2, 5, 10, and 15 years. The outcome of primary interest was the 15-year result for the Constant score. Secondary outcome measures included the self-report section of the American Shoulder and Elbow Surgeons (ASES) score; the Short Form-36 (SF-36) Health Survey; assessments of pain, motion, and strength; and patient satisfaction. Tear-size increase in unrepaired tears was assessed by sonography. Statistical analysis was by mixed-model analysis for repeated measurements and by intention to treat. Eighty-three (81%) of 103 patients attended the 15-year follow-up. Fifteen of 51 patients in the physiotherapy group had crossed over to secondary surgery. Results from primary tendon repair were superior by a mean difference of 11.8 points for the Constant score (p = 0.001), 13.9 points for the ASES score (p < 0.001), 1.8 cm on a 10-cm visual analog scale for pain (p < 0.001), and 16.2° and 22.4°, respectively, for pain-free abduction and flexion (p = 0.04 and 0.001). On the SF-36, differences did not reach significance for any of the scoring scales. In 26 tears treated by physiotherapy only, the mean tear size had increased from 16.2 to 31.6 mm in the anterior-posterior direction. Long-term outcomes from primary tendon repair remained superior to physiotherapy up to 15 years of follow-up, supporting its use as the primary treatment for small-to-medium-sized rotator cuff tears.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
New Technique for Treatment of Spondylolysis and Contralateral Facet Fracture Using Navigation and Robotics
Authors: Nilssen Paal K. , Finkel Ryan A. , Narendran Nakul , Skaggs David L. , Walker Corey T. 
Published: August 2024

Case:
A healthy 15-year-old male competitive hockey player presented with acute-on-chronic lower back pain was found to have a bilateral pars defect. After conservative treatment, subsequent computed tomography imaging demonstrated partial healing of the right-sided facet fracture but persistent left-sided pars fracture. A novel technique was performed, using robotic navigation to assist in laminar screw placement and to determine the optimal trajectory for subsequent microscopic surgery and bone grafting.

Conclusion:
Robotic navigation can be safely used to not only guide precise laminar screw placement for fixation and direct repair but also to provide guidance for microscopic tubular bone grafting of the pars defect.
A Volcanic Tephra-Based Non-Portland Cement System for Well Cementing Sustainability
Authors: Abdelaal Ahmed , Elkatatny Salaheldin , Abd El Fattah Ahmed M. 
Published: August 2024

Summary
Although Portland cement (PC) is extensively used in oil and gas well cementing for different applications such as zonal isolation and plugging, it does have technical and environmental drawbacks. PC is responsible for approximately 8% of global carbon dioxide (CO2) emissions and consumes massive energy while manufacturing. Geopolymer cements, which are made from nontraditional, non-PC ingredients, have garnered attention as potential candidates for oilwell cementing due to their low CO2 footprint and less energy consumption. This work introduces a proposed non-PC system that totally replaces PC using volcanic tephra (VT) and an alkaline solution. The study started by collecting, crushing, and sieving VT until it became a fine VT powder. Rheological properties, thickening time, unconfined compressive strength, and dynamic elastic properties were also assessed for the developed formulation. Sedimentation evaluation was conducted using the API method and nuclear magnetic resonance (NMR). The experimental evaluation included thermogravimetric analysis, Fourier transform infrared spectroscopy, X-ray diffraction, X-ray fluorescence, and particle-size distribution. The developed 15.8 ppg VT-based geopolymer used a 4 M sodium hydroxide (NaOH) solution and VT only. The 24-hour unconfined compressive strength was 2,900 psi, with a Poisson’s ratio of 0.29 and a Young’s modulus (YM) of 1.11 Mpsi. The developed formulation had a thickening time of 3.5 hours at a bottomhole circulation temperature of 170°F without using any retarder. The density variation between the top and bottom sections was only 0.65%. This work introduces a new cement system made of VT without any processing except milling and sieving. This reduces the overall carbon footprint and costs of oilwell cementing operations.
Optimizing Refracturing Models in Tight Oil Reservoirs: An Integrated Workflow of Geology and Engineering Based on Seepage-Stress Real-Time Cross-Coupling Strategy
Authors: Ren Jiawei , Chen Junbin , Lu Hongjun , Bai Xiaohu , Yu Wei 
Published: August 2024

SummaryIntegrated modeling of refracturing is a comprehensive and complex task for engineers involved in field development, especially in previously developed mature fields. The modeling process requires consideration of numerous factors to accurately predict fracture propagation patterns during refracturing and production. During the initial fracturing process, hydraulic fractures generate an altered induced stress field. Later, during the post-fracturing production process, hydrocarbon extraction causes formation pore pressure depletion, leading to further alterations in the stress field. However, due to the complexity of these phenomena, most existing workflows simplify the coupled simulation problems of stresses at different stages in the modeling process. Consequently, this often results in questionable hydraulic fracture geometries during refracturing and suboptimal refracturing designs. The goal of this study is to develop a novel integrated workflow for refracturing, specifically tailored for complex fracture networks in tight oil reservoirs. This model incorporates the hydraulic fracture propagation process during the initial fracturing and dynamic stress changes during the initial production process. It employs artificial intelligence algorithms to calibrate the wellhead treating pressure using a physics-based model, enabling a better understanding of the initial fracturing fracture geometries. The production history match is then conducted based on the initially calibrated hydraulic fracture geometries, preserving the precision of the original fracture geometry. In addition, geomechanics modeling is conducted to obtain dynamic stress changes during the initial production process. For the refracturing design, the fracture propagation model for the refracturing process is later conducted on the depleted stress field. Following a 240-day period after refracturing, the production history is matched using an artificial intelligence–assisted reservoir simulator. Our results indicate that, due to prolonged production, significant changes occur in the stress field during the initial development period, with an average horizontal stress deviation angle of approximately 35° in the near-well zone. With the combined influence of the changing stress field and natural fractures, refracturing results in longer and more complex hydraulic fracture geometries, ultimately increasing individual well production.
Global proteomics reveals pathways of mesenchymal stem cells altered by Mycobacterium tuberculosis.
Authors: Kaur Simran , Angrish Nupur , Vasudevan Madavan , Khare Garima 
Published: August 2024

Abstract

Mycobacterium tuberculosis (M. tb) has a remarkable ability to persist inside host cells. Several studies showed that M. tb infects and survives inside bone marrow mesenchymal stem cells (BM-MSCs) escaping the host immune system. Here, we have identified various cellular pathways that are modulated in human BM-MSCs upon infection with virulent M. tb and the proteomic profile of these cells varies from that of avirulent M. tb infected cells. We found that virulent M. tb infection reshapes host pathways such as stem cell differentiation, alternative splicing, cytokine production, mitochondrial function etc., which might be modulated by M. tb to persist inside this unconventional niche of human BM-MSCs. Additionally, we observed that virulent M. tb infection suppresses various cellular processes. This study uncovers the differences in the host proteomic profiles resulting from the virulent versus avirulent M. tb infection that can pave the way to identify host-directed therapeutic targets for the treatment of tuberculosis.
Clinical significance of peripheral blood inflammatory cells and fibrinogen in prostate cancer and prognosis
Authors: Zhang Wei , Ma Yuan , Huang Hua , Liu Yang , Shao Yuan , Liu Zihao , Liu Liwei , Wang Yong 
Published: August 2024

Abstract

Objective: To explore the relationship between peripheral blood inflammatory cells and fibrinogen and the clinicopathological characteristics of the prostate, and to assess their clinical value in evaluating prostate cancer.
Methods: A retrospective analysis was conducted on the clinicopathological data of 429 patients who underwent prostate biopsies at the Second Hospital of Tianjin Medical University between June 2020 and December 2022. The levels of neutrophils, lymphocytes, monocytes, platelets, and plasma fibrinogen in peripheral blood before surgery in patients with prostate cancer and benign prostatic hyperplasia were analyzed. Further comparisons were made between the levels of inflammatory cells and fibrinogen in peripheral blood in patients with prostate cancer at different stages, different Gleason scores, and with or without bone metastases.
Results: The levels of inflammatory cells and fibrinogen in preoperative prostate cancer patients showed statistically significant differences compared to those with benign prostatic hyperplasia (P<0.05). Specifically, fibrinogen levels were significantly elevated in patients with stage 4 prostate cancer (4.13±1.40 g/L), Gleason scores of 9-10 (5.12±1.20 g/L), and bone metastases (4.11±1.48 g/L) (P<0.001). Fibrinogen levels exhibited a positive correlation with prostate pathology results, cancer stage, Gleason score, presence of bone metastases, and PSA levels (P<0.001).
Conclusions: The levels of preoperative peripheral inflammatory cells and fibrinogen are closely linked to prostate pathology outcomes. Moreover, the level of fibrinogen demonstrates potential as a prognostic indicator for disease progression and prognosis in prostate cancer patients.
A study of mixed teaching method based on BOPPPS combined with rain classroom in ophthalmology probation
Authors: Xu Zheng yang , Yue Xiaoli , She Xiaomeng 
Published: August 2024

Abstract

To explore the application effect of mixed teaching method based on BOPPPS and rain classroom in ophthalmology probation.
Objective The 24 regular students in our hospital were randomly divided into the experimental group and the control group.
Methods Forty ophthalmology trainees in our hospital were randomly divided into experimental group and control group. The control group adopted the classical LBL teaching method, while the experimental group adhered to the student-led method and carried out the mixed teaching method based on BOPPPS and rain classroom, according to six steps: bridge-in, objectives, pre-assessment, participatory learning, post-assessment and summary.
Results The theoretical and operational scores of the experimental group were significantly higher than those of the control group.
Conclusion The mixed teaching method based on BOPPPS combined with rain classroom can improve the effect of ophthalmology internship.
KDELR1 regulates chondrosarcoma drug resistance and malignant behavior through Intergrin-Hippo-YAP1 axis
Authors: Wei Haifeng , Yin Huabin , Jiang Dongjie , Li Yongai , Chen Wenjun , Zhang Jie , Yang Xinghai , Hu Jinbo 
Published: August 2024

Abstract

Chondrosarcoma (CS) is the second most common primary bone malignancy, known for its unique transcriptional landscape that renders most CS subtypes resistant to chemotherapy, including neoadjuvant chemotherapy commonly used in osteosarcoma treatment. Understanding the transcriptional landscape of CS and the mechanisms by which key genes contribute to chemotherapy resistance could be a crucial step in overcoming this challenge. To address this, we developed a single-cell transcriptional map of CS, comparing it with osteosarcoma and normal cancellous bone. Our analysis revealed a specific increase in KDEL receptor 1 (KDELR1) expression in CS, which was closely associated with CS prognosis, tumor aggressiveness, and drug resistance. KDELR1 plays a key role in regulating membrane protein processing and secretion, as well as contributing to tumor extracellular matrix (ECM) formation and drug resistance. Further investigation using mass spectrometry proteomics and transcriptomics uncovered KDELR1's involvement in modulating the Hippo-YAP pathway activity in CS cells. The KDELR1-Integrin-PLCγ-YAP1 axis emerges as a critical process mediating drug resistance and malignant behavior in CS, offering novel insights and potential therapeutic targets for CS treatment.
Study on the shrinkage and restrained cracking of concrete with different surface curing methods
Authors: Wang Jiahe , Li Huajian , Tan Yanbin , Wang Jiaxuan , Gao Yu 
Published: August 2024

Abstract

The shrinkage and steel ring restrained cracking process of concrete using plastic film (PF), controlled permeability formwork liner (CPFL) and moisture retention curing film (MRCF) were experimentally measured using the designed test devices; A two-stage model for concrete creep considering humidity levels was established and the creep parameters were calibrated based on experimental results under sealed conditions; The uniform compressive stress of steel ring was calculated using the above model when the concrete using PF, CPFL and MRCF three different curing methods. The experimental and theoretical results show that: The surface curing method has a significant impact on the shrinkage deformation and restrained cracking process of concrete. The curing method should be adapted to the characteristics of the concrete body (w/b), otherwise there will be negative effects. CPFL can effectively reduce the drying shrinkage and the risk of restrained cracking of concrete by reducing the local w/b on the surface of concrete and forming a dense protective layer. It has a better effect on the low and medium strength grade concrete (C30 and C50), but has adverse effects on high-strength concrete (C80); MRCF can effectively reduce the shrinkage deformation and the risk of restrained cracking of concrete through the water supplement effect of the pre-absorbent materials. It has a better effect on the high-strength concrete, while its effect on low and medium strength grade concrete is relatively small; The two-stage creep model of concrete can better describe the differences in creep effects of concrete under different humidity levels. And the effective stress of the steel ring restraint concrete under different curing methods was accurately calculated using the model.
The use of ZnO for the stabilisation of C3S polymorphs
Authors: Queiroz Luciana , Barbosa Waleska , Kirchheim Ana Paula , Bergmann Carlos 
Published: August 2024

Abstract

The doping technique is widely used to stabilise C3S polymorphs, combined with synthesis temperature and cooling techniques. This work studied the doping technique using ZnO as a dopant at contents of 1.5, 2.0, 4.0, 8.0, and 10.0wt% and evaluated its effect on the polymorphism and reactivity of C3S. The characterisation of the phases in the anhydrous state was carried out by X-ray diffraction (XRD), and the effect of doping on chemical bonds and displacements in the crystalline structure was identified by Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy (RAMAN). Hydration was assessed using isothermal calorimetry and X-ray diffraction (XRD) techniques. The results show a delay in the hydration process in all the doped pastes, a reduction in the average crystallite size with increasing dopant content, and changes in the displacements and symmetry of the polymorphs.
Optimizing radicle-tip cutting for improved growth and lateral root formation in pistachio seedlings
Authors: Osku Mozhdeh , Roozban Mahmoud Reza , Sarikhani Saadat , Lawson Shaneka , Arab Mohammad Mehdi , Vahdati Kourosh 
Published: August 2024

Abstract

Root architecture critically influences plant growth and survival. Pistachio plants face challenges because of the limited lateral roots within a taproot system and the poor survival rates if the primary root tip is severed during transplantation. This study investigated the effects of radicle-tip cutting (RC) on lateral root formation and growth of Pistacia vera L. ‘Ohadi’ seedlings. A factorial experiment with varying radicle lengths (L1-L5) and cutting site portions (CS1-CS5) was conducted. Control plants had an intact radicle tip. Following treatment, seedlings were transferred to 2 L pots filled with perlite, and nourished weekly with half-strength Hoagland's solution. After nine weeks, growth parameters and root characteristics were assessed. Results indicated that optimal radicle-tip cutting occurred at a radicle length of 2–3 cm (L3), with an ideal cutting distance of 3 mm from the radicle-tip (CS3). This treatment (L3CS3) led to improved growth (plant height, leaf area, shoot fresh weight (FW), root FW, shoot dry weight (DW), root DW) and root architecture (number of lateral roots (NLR), network depth (NWDP), network volume (NWVL), network convex area (NWCA) parameters, enhancing plant vitality. These findings offer valuable insights for nurserymen aiming to produce pistachio seedlings with robust lateral roots and higher post-transplantation survival rates.
Creek system and regional patterns of Juncus roemerianus stress and links to salt marsh loss on the Florida Gulf Coast
Authors: Verhulst Stephanie , Conlin Matthew , Adams Peter , Adams Carrie Reinhardt 
Published: August 2024

Abstract

Sea-level rise and adverse environmental conditions (e.g., drought, herbivory, and altered sedimentation and hydrology) stress coastal salt marsh vegetation, leading to reduced productivity, die-off, and subsequent marsh loss. Potential for loss may vary spatially within a single marsh creek system, as well as at the larger landscape-scale level across creek systems. Spatial patterns of plant stress that may signal future loss could inform management and conservation strategies. To inform predictions of marsh loss, in a field study in 12 Juncus roemerianus marshes on Florida’s Big Bend, we observed spatial patterns of plant stress and potential environmental drivers 1) within individual creek systems and 2) across a region of multiple creek systems. Juncus stress was higher at the creek margin (lower belowground biomass production and higher proline concentrations, K+ and Na+ ion levels, and relative stem water content) where soil salinity was higher and soil nutrients were lower. Patterns were not predicted by elevation alone, and other indicators did not similarly vary within creeks, but differed between creek systems, which often was explained by proximity to large freshwater inputs. Management strategies that account for these observed within- and between-creek patterns of stress, which represent symptoms that likely precede die-off and marsh loss, may best increase marsh persistence. This uniquely comprehensive data set (15 Juncus responses and 8 environmental variables across 12 marshes) highlights the challenge of determining stress patterns across a broad region and the necessary monitoring to generate information needed to spatially prioritize management efforts to ameliorate marsh loss.
ALOX12B and PRMT5 inhibit stemness and EMT in esophageal squamous cell carcinoma by promoting decorin expression
Authors: Gu Yanhong , Zhang Xiao , Cao Shurui , Zhou Chenchen , Jiang Wen , Deng Xiaheng , Wang Hongshun , Hui Bingqing , Zhen Fuxi 
Published: August 2024

Abstract

Stemness is crucial for cancer metastasis and recurrence. We developed a novel pipeline to reveal cancer stemness related genes in esophageal squamous cell carcinoma (ESCC). ALOX12B was identified for its expression inversely correlated with ESCC stemness and significantly associated with tumor grade. Overexpression of ALOX12B in poorly differentiated ESCC cells suppressed cancer stemness, proliferation, invasion and migration. DCN was identified as a target gene by ALOX12B, which in turn inhibited ESCC stemness and EMT. Mechanistically, ALOX12B interacted with PRMT5, inhibiting its methyltransferase activity and reducing the deposition of PRMT5-mediated histone marker H4R3me2s at the DCN gene promoter. PRMT5 knockdown reduced H4R3me2s accumulation, reactivating DCN expression. DCN silencing negated the reduction of EMT markers and the inhibition of tumor stemness and invasion induced by PRMT5 depletion. Notably, intervention with PRMT5 enzymatic activity using GSK3326595 (GSK) showed a significant inhibitory effect on the growth of ESCC cells and xenografts with low ALOX12B expression both in vitro and in vivo. In conclusion, ALOX12B functionally interacts with PRMT5 to inhibit stemness and EMT in ESCC by promoting DCN expression. These findings suggest that PRMT5 targeting may represent a promising therapeutic strategy for the treatment of poorly differentiated ESCC with low ALOX12B expression.