bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trade show performance evaluation based on stakeholder theory: A case study of trade shows in Changsha, China
Authors: Wang Yi , Wang Jing , Cai Weimin 
Published: July 2024

AbstractA performance evaluation index system is built in this paper with four dimensions (service performance, sales performance, behavioral performance, and social performance) and 14 criteria considering the requirements of key stakeholders. The BWM‐CRITIC‐TOPSIS model is then developed for a comprehensive trade show performance evaluation. An illustrative application is carried out based on four trade shows held in Changsha, China, to demonstrate the validity and acceptability of the proposed evaluation index system and model. Findings indicate that social performance is assigned the highest weight coefficient: it is considered to be the essential criterion that constrains the performance level. The evaluation results show that the overall performance levels of the sampled trade shows increased from 2022 to 2023 and have gradually recovered from the COVID‐19 crisis. Their adaptability and flexibility in response to changing surroundings could be enhanced by meeting various stakeholders' expectations, which is also essential for improving their own resilience.
The impact of age‐related differences in emotion dysregulation on refugee mental health and social outcomes
Authors: Byrow Yulisha , Nickerson Angela , Specker Philippa , Bryant Richard , O'Donnell Meaghan , McMahon Tadgh , Mau Vicki , Liddell Belinda 
Published: July 2024

AbstractThe refugee experience is typically characterized by exposure to numerous premigration traumatic events and postmigration stress in the resettlement environment. Refugees’ experiences can lead to elevated rates of psychopathology, including posttraumatic stress disorder (PTSD) and depression. Emotion regulation is a key mechanism contributing to mental health outcomes among refugees. This study examined the impact of age on the association between emotion regulation and critical social outcomes relevant to refugee resettlement, such as social engagement and functional impairment. Participants were 1,081 Arabic‐, Farsi‐, Tamil‐ and English‐speaking adult refugees. Premigration trauma exposure, postmigration stressors, PTSD symptoms, depressive symptoms, emotion regulation, social engagement, and functional impairment were measured. A series of hierarchical regression and Poisson regression analyses revealed emotion dysregulation as a significant predictor of functional impairment, β = .36, p < .001, and social engagement, Exp B = 0.99, p = .002. A significant interaction between age and emotion dysregulation was associated with both PTSD, β = .05, p = .048 and depressive symptoms, β = .06, p = .010, suggesting a stronger positive association between emotion dysregulation and both PTSD and depressive symptom severity for older individuals. Postmigration stressor exposure, emotion dysregulation, and older age are important factors that may negatively impact social engagement and functional impairment in the resettlement environment. Additionally, higher levels of trauma exposure may negatively impact social engagement. These findings have implications for public health and social services in the context of resettled refugee communities.
Role of Shear Wave Elastography for Assessment of Renal‐Allograft Fibrosis and its Correlation With Histopathology
Authors: Ruidas Surojit , Lal Hira , Prasad Raghunandan , Sharma Srishti , Agarwal Surabhi , Singh Ranvijai , Prasad Narayan , Patel Manas Ranjan , Kushwaha Ravi Shankar , Jain Manoj 
Published: July 2024

ObjectivesTo investigate whether shear wave elastography (SWE) can accurately identify interstitial fibrosis and tubular atrophy (IFTA) in chronic renal allograft injury (CRAI) and whether it can differentiate between different grades of IFTA.Materials and MethodsProspective observational study on renal transplant recipients who presented with CRAI. Patient selection was done on the basis of clinical presentation, serum creatinine, and eGFR levels. Biopsy and SWE were performed and SWE values were correlated with histopathological findings according to Banff schema. Receiver operating characteristic (ROC) was also analyzed to assess the diagnostic efficacy of SWE.ResultsSxity‐one patients were evaluated. Ten patients had no IFTA, 33 patients had mild IFTA, 16 patients had moderate IFTA, and 2 patients had severe IFTA. Mean parenchymal stiffness values in no IFTA, mild IFTA, moderate IFTA and severe IFTA were 39.86 ± 2.17 kPa (3.64 ± 0.09 m/s), 41.59 ± 3.36 kPa (3.71 ± 0.15 m/s), 47.59 ± 3.34 kPa (3.98 ± 0.14 m/s), and 53.83 ± 1.41 kPa (4.25 ± 0.03 m/s), respectively. SWE values of parenchymal stiffness reached statistical significance to differentiate between mild, moderate, and severe IFTA. ROC analysis revealed cut‐off values of 45.09 kPa (3.89 m/s) to differentiate between mild IFTA and moderate IFTA, 52.06 kPa (4.18 m/s) to differentiate between moderate IFTA and severe IFTA with acceptable sensitivity and specificity.ConclusionSWE is a non‐invasive and cost‐effective imaging tool to evaluate the disease status of renal allografts affected by CRAI. Thus, it can be of paramount importance if added to the regular follow‐up imaging protocol of renal allograft along with grayscale and Doppler imaging.
Autologous matrix‐induced chondrogenesis provides better outcomes in comparison to autologous minced cartilage implantation in the repair of knee chondral defects
Authors: Behrendt Peter , Eggeling Lena , Lindner Anja , von Rehlingen‐Prinz Fidelius , Krause Matthias , Hoffmann Michael , Frosch Karl‐Heinz , Akoto Ralph , Gille Justus 
Published: July 2024

AbstractPurposeIn symptomatic mid‐sized focal chondral defects, autologous matrix‐induced chondrogenesis (AMIC) and minced cartilage implantation (MCI) offer two versatile treatment options. This study aimed to conduct a matched‐patient analysis of patient‐reported outcome measures to compare these two surgical treatment methods for focal chondral defects.MethodsAt the first centre, patients underwent a single‐stage procedure in which autologous cartilage was hand‐minced, implanted into the defect and fixed with fibrin glue. At the second centre, patients underwent AMIC, which was fixed in place with fibrin glue. All patients were seen 2–4 years postoperatively. Postoperative outcomes were assessed using the visual analogue scale for pain (VAS), the Lysholm score and the five domains of the knee osteoarthritis outcome score (KOOS). Patients from each surgical centre were matched by age, sex, defect size and defect localisation.ResultsIn total, 48 patients from two surgical centres (24 from each site) were matched for sex, age (MCI 30.3 ± 14.9 years vs. AMIC 30.8 ± 13.7 years) and defect size (MCI 2.49 ± 1.5 cm2 vs. AMIC 2.65 ± 1.1 cm2). Significantly better scores in the AMIC cohort were noted for VAS (p = 0.004), Lysholm (p = 0.043) and the KOOS subscales for pain (p = 0.016) and quality of life (p = 0.036). There was a significantly greater proportion of positive responders for Lysholm in the AMIC group (92%) compared with the MCI group (64%).ConclusionsThe AMIC procedure delivers superior patient outcomes compared with hand‐minced autologous cartilage implantation. These are mid‐term outcomes, with follow‐up between 2 and 4 years.Level of EvidenceLevel III.
Impact of Preoperative Multidisciplinary Conference on Head and Neck Reconstruction Outcomes
Authors: Dang Sophia , Hashimi Basil , Tang Anthony , Kubik Mark W. , Solari Mario G. , Sridharan Shaum S. 
Published: July 2024

IntroductionHead and neck oncologic resections with microvascular reconstruction are lengthy and complex procedures with inefficiencies in the operating room (OR) associated with increased complications and higher costs. Multidisciplinary care has become increasingly used to provide improved care for complex patients; however, the potential role of this has not yet been studied in head and neck microvascular free flap procedures.MethodsPatients between 2016 and 2022 treated before and after implementation of the conference were included. Primary outcome was total procedure time (TPT). Demographics, operative details, and postoperative complications were also collected.Results233 patients were included in the preconference group and 330 in the post‐conference group. Preconference mean (SD) age was 61.6 (12) years versus 62.9 (12) years in the post‐conference group. The post‐conference group was associated with shorter mean (SD) TPT (629 [117] vs. 719 [134] minutes), less mean (SD) estimated blood loss (ESD) (230 [201] mL vs. 306 [211] mL), fewer prolonged lCU stays (>1 day), and fewer returns to the operating room (RTOR). The post‐conference group was associated with TPT ≤9 h (p < 0.001) on multivariate analysis. Factors associated with TPT greater than 9 h include history of head and neck radiation (p = 0.003), bony reconstruction (p = 0.05), stage IVa (p = 0.009), and stage IVb cancer (p < 0.001).ConclusionsImplementation of the multidisciplinary conference in head and neck surgery was associated with reduced TPT and reduced OR return. Our study suggests preoperative planning conferences may improve surgical efficiency and outcomes in head and neck oncologic resections with microvascular free flap reconstruction.Level of Evidence3 Laryngoscope, 2024
Impact of moisture on the degradation and priming effects of poly(lactic acid) microplastic
Authors: Xiao Congli , Liu Xinhui , Wang Dandan , Xue Jiantao , Liu Lihu , Yu Yongxiang , Yao Huaiying 
Published: July 2024

AbstractThe degradation of biodegradable microplastics (MPs) can either stimulate or inhibit the decomposition of soil organic carbon (SOC), but the factors influencing these phenomena remain unclear. In this study, we used the 13C natural abundance to differentiate between carbon dioxide (CO2) arising from the mineralization of SOC and poly(lactic acid) (PLA) MP under varying soil water holding capacity (WHC) in alkaline and acidic soils. We also quantified the incorporation of soil‐ or PLA‐derived carbon (C) into phospholipid fatty acid (PLFA)‐distinguishable microbial groups. An increase in soil moisture did not significantly affect PLA MP degradation in alkaline soil, but significantly increased PLA degradability in acidic soil. In particular, the percentages of PLA‐derived C incorporated into PLFA‐distinguishable gram‐negative and gram‐positive bacteria were 14%–63% and 5%–33%, respectively, in all the treatments. The presence of PLA MP induced positive priming effects from 0 to 20 d in all the treatments but subsequently induced negative priming effects under some conditions. The total priming effects induced by PLA MP were significantly greater in alkaline soil with ≥70% WHC (37–43 mg C kg−1 soil) than in this soil with 50% WHC (8.6 mg C kg−1 soil). The total priming effect was 72–78 mg C kg−1 soil in acidic soil with ≤70% WHC, but a negative priming effect was observed in this soil with 90% WHC (−56 mg C kg−1 soil). In alkaline soil, the dissolved organic carbon content was positively correlated with the priming effect, but a negative relationship was observed between the priming effect and the amount of soil‐derived C incorporated into gram‐negative bacteria and fungi. In acidic soil, a positive correlation was found between the priming effect and the soil nitrate content. In summary, our findings indicate that 0.4%–2.8% of PLA MP was degraded in soils after 2 months, and that the intensity and direction of the priming effect induced by PLA MP are regulated by soil moisture and pH, but further exploration is needed to elucidate the microbial mechanisms underlying these effects.
All‐Dielectric Meta‐Waveguides for Flexible Polarization Control of Guided Light
Authors: Asadulina Syuzanna , Bogdanov Andrey , Yermakov Oleh 
Published: July 2024

AbstractGuided waves are the perfect carriers of electromagnetic signals in planar miniaturized devices due to their high localization and controlled propagation direction. However, it is still a challenge to control the polarization of propagating guided waves. In this work, the broadband polarization TE‐TM degeneracy of highly localized guided waves propagating along an all‐dielectric metasurface and a subwavelength chain of dielectric high‐index cylinders is discovered, both theoretically and experimentally. Using the discovered near‐field polarization degree of freedom, the polarization transformation for guided waves propagating along a subwavelength chain of dielectric cylinders at any frequency within the finite spectral range is demonstrated experimentally. Namely, the simplest planar near‐field polarization device – the quarter‐wave‐retardation (linear‐to‐circular) polarization transformer of guided waves is implemented. The results obtained discover the polarization degree of freedom for guided waves paving the way toward numerous applications in flat optics and planar photonics.
Suppressing Side‐Scattering on Laser‐Written Bragg Gratings for Back‐Reflection Engineering in Fibers
Authors: Hu Jiacheng , Wang Yuying , Lau Kuen Yao , Han Xuhu , Firstov Sergei , Zhong Lijing , Wang Yiping , Qiu Jianrong 
Published: July 2024

AbstractLaser direct writing (LDW) is versatile in structuring fibers with micro‐sized functional elements such as fiber Bragg grating (FBG) and backscattering centers by finely manipulating back and side scattering from laser‐induced refractive index modified (RIM) points. However, the side‐scattering is a lesser‐explored property in laser‐structured fibers. In this work, a concise physical model is established to understand the side‐scattering as a combined effect of microstructure and geometry of RIM points. Based on a single‐pulsed LDW method, the parametric decoupling between scattering loss (α) and coupling strength (κ) coefficients of FBGs is reported, whose cross‐section is customized to have a flattened ellipse with thoroughly positive RIM, enabling controllable reflectivity from −21.33 dB to −0.0018 dB while maintaining narrow bandwidth and low loss. Exemplarily, a designed FBG realizes ultra‐low loss of 0.008 dB with a resonance attenuation of 10.81 dB, exhibiting a record‐breaking κ/α of 2083. Using this FBG as the high‐reflective mirror of a home‐made bismuth‐doped fiber laser, narrow‐band lasing with a high optical signal‐to‐noise ratio of ≈43 dB is achieved, demonstrating flexibilities of the proposed approach in customizing both back‐ and side‐scattering in fibers and opening up wide opportunities for combining multifunctional components into optical fibers and realizing all‐fiber networks.
High Resolution Nanostructuring of Perovskites With Tunable Morphologies by Ultrafast Laser Direct Writing
Authors: Gao Kai , Sun Ke , Chen Chenduan , Wu Jiajia , Li Zengling , Qiu Jianrong , Tan Dezhi 
Published: July 2024

AbstractMetal halide perovskites (MHPs) have attracted increasing attention in various optoelectronic devices due to their exceptional optical and electrical properties. The high precision patterning of MHPs is crucial adjective for device fabrication, while it is severely hindered by the active and sensitive chemistry of MHPs. In this work, high resolution and tunable nanostructuring of 2D MHP films are achieved by ultrafast laser direct writing (ULDW). The feature size of the created structure is down to 47 nm (λ/21), which is far beyond the diffraction limit of the optical system. The study proves the critical influence of the thermodynamic properties of materials on structure morphologies and establish a new mechanism of molten phase self‐evolution (MPSE) for the formation of super‐solution convex structures, which provides a new understanding for ultrafast laser‐matter interaction and high‐resolution patterning with ULDW. Different structure morphologies bring tunable optical properties. The applications are demonstrated in multimode information storage and encryption. The findings open new approaches to achieve hyperfine multi‐morphological structures on MHPs, which can boost many MHPs integration applications in nanophotonics, on‐chip electronics, and information encryption.
Isolation of Polyethylene Glycol with Larger Molecular Weights via Metal–Organic Frameworks
Authors: Huang Yali , Ren Ziye , Fan Ziwen , Zhang Hanwen , Wu Yueyue , Wang Yue , Hu Zhuoyi , Quan Xueheng , Wang Zhao , Niu Zheng 
Published: July 2024

AbstractPolymer products typically present as mixtures with a range of molecular weights, which notably influence the expression of their properties. In this study, a technique is proposed to separate polyethylene glycol (PEG) mixtures of varying molecular weights using metal–organic frameworks (MOFs), thereby narrowing down their molecular weight distribution. Due to the hydrogen bond interactions between PEG and ‐OH groups in the pores of NU‐1000, NU‐1000 can selectively adsorb PEG with larger molecular weights from PEG mixture. This separation method consistently yields with narrower molecular weight distribution across multiple cycles. This is the first application of MOFs in regulating the dispersity (Ð) of polymers in solution, providing a novel approach for separating and purifying mixed molecular weight polymers.
Circular RNA‐based neoantigen vaccine for hepatocellular carcinoma immunotherapy
Authors: Wang Fei , Cai Guang , Wang Yingchao , Zhuang Qiuyu , Cai Zhixiong , Li Yingying , Gao Shaodong , Li Fang , Zhang Cuilin , Zhao Bixing , Liu Xiaolong 
Published: July 2024

AbstractmRNA vaccines are regarded as a highly promising avenue for next‐generation cancer therapy. Nevertheless, the intricacy of production, inherent instability, and low expression persistence of linear mRNA significantly restrict their extensive utilization. Circular RNAs (circRNAs) offer a novel solution to these limitations due to their efficient protein expression ability, which can be rapidly generated in vitro without the need for extra modifications. Here, we present a novel neoantigen vaccine based on circRNA that induces a potent anti‐tumor immune response by expressing hepatocellular carcinoma‐specific tumor neoantigens. By cyclizing linearRNA molecules, we were able to enhance the stability of RNA vaccines and form highly stable circRNA molecules with the capacity for sustained protein expression. We confirmed that neoantigen‐encoded circRNA can promote dendritic cell (DC) activation and enhance DC‐induced T‐cell activation in vitro, thereby enhancing T‐cell killing of tumor cells. Encapsulating neoantigen‐encoded circRNA within lipid nanoparticles for in vivo expression has enabled the creation of a novel circRNA vaccine platform. This platform demonstrates superior tumor treatment and prevention in various murine tumor models, eliciting a robust T‐cell immune response. Our circRNA neoantigen vaccine offers new options and application prospects for neoantigen immunotherapy in solid tumors.
CRISPR technology in human diseases
Authors: Feng Qiang , Li Qirong , Zhou Hengzong , Wang Zhan , Lin Chao , Jiang Ziping , Liu Tianjia , Wang Dongxu 
Published: July 2024

AbstractGene editing is a growing gene engineering technique that allows accurate editing of a broad spectrum of gene‐regulated diseases to achieve curative treatment and also has the potential to be used as an adjunct to the conventional treatment of diseases. Gene editing technology, mainly based on clustered regularly interspaced palindromic repeats (CRISPR)–CRISPR‐associated protein systems, which is capable of generating genetic modifications in somatic cells, provides a promising new strategy for gene therapy for a wide range of human diseases. Currently, gene editing technology shows great application prospects in a variety of human diseases, not only in therapeutic potential but also in the construction of animal models of human diseases. This paper describes the application of gene editing technology in hematological diseases, solid tumors, immune disorders, ophthalmological diseases, and metabolic diseases; focuses on the therapeutic strategies of gene editing technology in sickle cell disease; provides an overview of the role of gene editing technology in the construction of animal models of human diseases; and discusses the limitations of gene editing technology in the treatment of diseases, which is intended to provide an important reference for the applications of gene editing technology in the human disease.
Small Particles, Big Potential: Polymeric Nanoparticles for Drug Delivery in Parkinson's Disease
Authors: Virameteekul Sasivimol , Lees Andrew J. , Bhidayasiri Roongroj 
Published: July 2024

AbstractDespite the availability of a number of efficacious treatments for Parkinson's disease, their limitations and drawbacks, particularly related to low brain bioavailability and associated side effects, emphasize the need for alternative and more effective therapeutic approaches. Nanomedicine, the application of nanotechnology in medicine, has received considerable interest in recent years as a method of effectively delivering potentially therapeutic molecules to the brain. In particular, polymeric nanoparticles, constructed from biodegradable polymer, have shown great promise in enhancing therapeutic efficacy, reducing toxicity, and ensuring targeted delivery. However, their clinical translation remains a considerable challenge. This article reviews recent in vitro and in vivo studies using polymeric nanoparticles as drug and gene delivery systems for Parkinson's disease with their challenges and future directions. We are also particularly interested in the technical properties, mechanism, drugs release patterns, and delivery strategies to overcome the blood–brain barrier. © 2024 International Parkinson and Movement Disorder Society.
Stress in Musicians with and Without Focal Dystonia Is Not Reflected in Limbic Circuit Activation
Authors: Alpheis Stine , Sinke Christopher , Burek Julian , Krüger Tillmann H.C. , Altenmüller Eckart , Scholz Daniel S. 
Published: July 2024

AbstractBackgroundMusicians' dystonia (MD) is a movement disorder with several established risk factors, but the exact pathophysiology remains unknown. Recent research suggests dysfunction in sensory‐motor, basal ganglia, cerebellar, and limbic loops as potential causes. Adverse childhood experiences are also considered risk factors.ObjectiveThis study aimed to investigate whether MD patients have experienced more childhood trauma, leading to increased stress reactivity and neural vulnerability to movement disorders.MethodsUsing functional magnetic resonance imaging and the Montreal Imaging Stress Task, 40 MD patients were compared with 39 healthy musicians (HMs). Whole‐brain analysis and regions of interest analysis were performed. Parameter estimates and subjective stress levels were compared between groups and correlated with the Childhood Trauma Questionnaire.ResultsMD patients reported significantly higher childhood trauma scores than healthy control subjects, but they did not differ in their subjective stress experiences. Stress‐related activity of limbic areas was neither found in the whole sample nor between the two groups. Instead, increased activity of visual association and temporal areas was observed, but this activation did not differ between patients and HMs. However, patients showed a tendency toward reduced precuneus activity under stress. Adverse childhood experiences were negatively correlated with precuneus, thalamus, and substantia nigra activity across all participants.ConclusionsOverall, MD patients and HMs had similar subjective and neurological reactions to stress but differed in childhood trauma experiences and precuneus activity under stress. Further research about the functional connectivity between precuneus, cerebellum, thalamus, and basal ganglia in musicians is needed. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.