bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the response to lenvatinib in partial responders using a Constrained-Disorder-Principle-based second-generation artificial intelligence-therapeutic regimen: a proof-of-concept open-labeled clinical trial
Authors: Sigawi Tal , Gelman Ram , Maimon Ofra , Yossef Amal , Hemed Nila , Agus Samuel , Berg Marc , Ilan Yaron , Popovtzer Aron 
Published: July 2024

IntroductionThe main obstacle in treating cancer patients is drug resistance. Lenvatinib treatment poses challenges due to loss of response and the common dose-limiting adverse events (AEs). The Constrained-disorder-principle (CDP)-based second-generation artificial intelligence (AI) systems introduce variability into treatment regimens and offer a potential strategy for enhancing treatment efficacy. This proof-of-concept clinical trial aimed to assess the impact of a personalized algorithm-controlled therapeutic regimen on lenvatinib effectiveness and tolerability.MethodsA 14-week open-label, non-randomized trial was conducted with five cancer patients receiving lenvatinib—an AI-assisted application tailored to a personalized therapeutic regimen for each patient, which the treating physician approved. The study assessed changes in tumor response through FDG-PET-CT and tumor markers and quality of life via the EORTC QLQ-THY34 questionnaire, AEs, and laboratory evaluations. The app monitored treatment adherence.ResultsAt 14 weeks of follow-up, the disease control rate (including the following outcomes: complete response, partial response, stable disease) was 80%. The FDG-PET-CT scan-based RECIST v1.1 and PERCIST criteria showed partial response in 40% of patients and stable disease in an additional 40% of patients. One patient experienced a progressing disease. Of the participants with thyroid cancer, 75% showed a reduction in thyroglobulin levels, and 60% of all the participants showed a decrease in neutrophil-to-lymphocyte ratio during treatment. Improvement in the median social support score among patients utilizing the system supports an ancillary benefit of the intervention. No grade 4 AEs or functional deteriorations were recorded.SummaryThe results of this proof-of-concept open-labeled clinical trial suggest that the CDP-based second-generation AI system-generated personalized therapeutic recommendations may improve the response to lenvatinib with manageable AEs. Prospective controlled studies are needed to determine the efficacy of this approach.
Temperament structures and the effectiveness of individual play in football
Authors: Bojkowski Łukasz , Tomczak Maciej 
Published: July 2024

BackgroundRegulatory Theory of Temperament distinguishes two traits involving the time course of responses and four relating to how energy is distributed and stored. This theory enables the presentation of entire structures of temperament traits and it is relevant for assessing an individual’s ability to process stimulation and influence their performance during competitions. In our cross-sectional study, these structures are examined in relation to the offensive, defensive, and comprehensive effectiveness of an individual player’s actions.MethodsThe study included 91 football players aged between 20 and 31 years, who had approximately 10 years of training experience. The Formal Characteristics of Behavior – Temperament Inventory was utilized to assess temperamental traits, while a simulation game was employed to evaluate the effectiveness of each individual player’s actions.ResultsResearch demonstrated that football players possessing a temperament structure that is closely aligned harmonized structure with a high capacity to process stimulation showed higher levels of individual efficacy in attack, defence, and comprehensive effectiveness of performance compared to football players with a harmonized temperament structure but a low capacity to process stimulation.ConclusionThe obtained result emphasises the significance of specific temperament structures in terms of matching the individual’s stimulation levels and the their ability to process it.
Reliability and minimal detectable change of the Yoni task for the theory of mind assessment
Authors: Isernia Sara , Cacciatore Diego Michael , Rossetto Federica , Ricci Cristian , Baglio Francesca 
Published: July 2024

IntroductionThe Theory of Mind (ToM) assessment is becoming essential to evaluate the response to a social cognition intervention and to monitor the progression of social abilities impairment in atypical conditions. In the Italian setting, the Yoni task has been recently validated in its short version (the Yoni-48 task) to evaluate ToM in the clinical setting. The present study aimed to verify the test-retest reliability and the Minimal Detectable Change (MDC) of the Yoni-48 task.MethodsThe Yoni-48 task was administered to 229 healthy adults at two evaluation sessions 3 weeks apart (mean days between sessions = 20.35 ± 1.75) by a psychologist. The test-retest reliability of the Yoni-48 task accuracy and response time was tested by the Intraclass Correlation Coefficient (ICC2,1, two-way random model, absolute agreement type). Then, the MDC95 and MDC90 were computed based on the standard error of measurement. Finally, the 95% limits of agreement were plotted (LOA plot) to visualize the difference and mean score of each pair of measurements.ResultsThe total Yoni-48 task accuracy, but not the response time score, showed a high ICC (&gt;0.80), with an MDC of 0.10. By plotting the LOA plot for the accuracy score no systematic trends were observed.DiscussionThis evidence will support the adoption of the Yoni task in longitudinal designs.
Improving triplet lamb survival: management practices used by commercial farmers
Authors: Erichsen Cathrine , Coombs Tamsin , Sargison Neil , McCoard Sue , Keady Tim W. J. , Dwyer Cathy M. 
Published: July 2024

IntroductionProlificacy has become an important breeding goal in sheep farming to increase farm profitability. With the adoption of improved genetics and management practices leading to increased lambing percentages, the proportion of triplet-born lambs has also increased on farms. However, mortality rates of triplet lambs are higher than for single- and twin-born lambs, and additional management inputs may be needed to support survival. The aim of this study was to identify factors that affect management practices that are considered important for triplet lamb survival by commercial farmers from the United Kingdom (UK), the Ireland (IRE), and New Zealand (NZ).MethodsAn online survey was developed and disseminated to farmers in each country, focusing on farmer demographics, flock characteristics, management practices and production outcomes. A total of 448 farmers completed the survey, from the UK (n = 168), IRE (n = 218), and NZ (n = 62).ResultsRespondents had larger flocks, higher scanning and lambing percentages than the country average for the UK and IRE. The mean percentage of triplet litters born within flocks was 9%, and lambs lost between scanning and lambing were 14% for UK, 15% for IRE, and 25% for NZ respondents (P = 0.063). Overall, 60% of all respondents reported to lamb indoors and 40% lambed outdoors, however NZ farmers almost exclusively lambed outdoors, whereas UK and IRE farmers lambed in both systems (P &lt; 0.001). NZ farmers were more likely to rear all triplet lambs with the ewe, whereas UK and IRE farmers were more likely to remove a lamb to rear by another ewe or artificially (P &lt; 0.001). Factors that influenced triplet lamb management practices of respondents in this study were respondent country of origin, flock size, age, and gender. In general, younger respondents (P &lt; 0.001), and female respondents (P &lt; 0.05), were more likely to engage in management activities that were considered to promote better triplet lamb survival, compared to older and male respondents respectively. These practices were associated with better lamb survival reported by respondents but were less likely to be carried out when flock size increased (P &lt; 0.001).DiscussionThe results of this survey highlight future priorities or communication strategies needed to improve triplet lamb survival.
Effect of Short-Term Lactic Fermentation on Polyphenol Profile and Antioxidant Capacity in White and Red Quinoa Varieties
Authors: Chu Rui , Uaila Eulalia , Ismail Tariq , Lazarte Claudia E. 
Published: July 2024

Quinoa (Chenopodium quinoa Willd.) is a pseudocereal originally grown in the Andean region of South America. This study focused on investigating the changes in phenolic profile and antioxidant capacity in white and red quinoa varieties after short-term fermentation with Lactiplantibacillus plantarum 299v®. During fermentation, pH and lactic acid formation were monitored every three hours until pH was below 4.6. The quinoa phenolic profile was quantified via LC–UV–MS. Total polyphenol content (TPC) and total antioxidant capacity (DPPH and FRAP) were determined via spectrophotometric methods. The findings showed that fermentation resulted in a significant increase (p < 0.001) in TPC from 4.68 to 7.78 mgGAE·100 g−1 for the white quinoa and from 5.04 to 8.06 mgGAE·100 g−1 for the red quinoa variety. Gallic acid was the most abundant phenolic acid detected in unfermented quinoa samples (averaging 229.5 μg·g−1). Fermented white quinoa showed an 18-fold increase in epicatechin, while catechin was found only in fermented red quinoa (59.19 μg·g−1). Fermentation showed a significantly positive impact on the iron-reducing antioxidant capacity (FRAP) of quinoa (p < 0.05). Red quinoa had a higher FRAP antioxidant capacity than the white variety; a similar trend was observed with the DPPH assay. There was a significant correlation (r > 0.9, p < 0.05) between TPC and antioxidant capacity. In conclusion, short-time lactic fermentation effectively increased phenolic content and antioxidant capacity in both quinoa varieties. Overall, red quinoa showed higher polyphenol content and antioxidant capacity compared to the white variety.
Infrared Matrix-Isolation and Theoretical Studies of the Reactions of Bis(benzene)chromium with Ozone
Authors: Kugel Roger W. , Ault Bruce S. 
Published: July 2024

Reactions of bis(benzene)chromium (Bz2Cr) and ozone (O3) were studied using low-temperature argon matrix-isolation infrared spectroscopy with supporting DFT calculations. When Bz2Cr and O3 were co-deposited, they reacted upon matrix deposition to produce two new prominent peaks in the infrared spectrum at 431 cm−1 and 792 cm−1. These peaks increased upon annealing the matrix to 35 K and decreased upon UV irradiation at λ = 254 nm. The oxygen-18 and mixed oxygen-16,18 isotopic shift pattern of the peak at 792 cm−1 is consistent with the antisymmetric stretch of a symmetric ozonide species. DFT calculations of many possible ozonide products of this reaction were made. The formation of a hydrogen ozonide (H2O3) best fits the original peaks and the oxygen-18 isotope shift pattern. Energy considerations lead to the conclusion that the chromium-containing product of this reaction is the coupled product benzene-chromium-biphenyl-chromium-benzene (BzCrBPCrBz). 2Bz2Cr+O3→H2O3+BzCrBPCrBz, ∆Ecalc=−52.13kcal/mol.
Improvement of Echinacea purpurea and Ganoderma lucidum Extracts with Cell Model on Influenza A/B Infection
Authors: Chen Bo-Kai , Chan Chi-Ho , Tsao Arthur , Wang Chin-Kun 
Published: July 2024

Since 2019, COVID-19 has been raging around the world. Respiratory viral infectious diseases such as influenza and respiratory syncytial virus (RSV) infection are also prevalent, with influenza having the ability to cause seasonal pandemics. While vaccines and antiviral drugs are available to prevent and treat disease, herbal extracts would be another option. This study investigated the inhibitory effects of extracts of Echinacea purpurea (EP) and Ganoderma lucidum (G. lucidum) and the advanced G. lucidum drink (AG) on influenza A/B viruses. To determine whether EP and G. lucidum extracts enhance cell immunity and thus prevent virus infection or act to directly suppress viruses, cell survival and hemagglutination (HA) assays were used in this study. Cells were treated with samples at different concentrations (each sample concentration was tested from the highest non-cytotoxic concentration) and incubated with influenza A/B for 24 h, with the results showing that both G. lucidum and EP extracts and mixtures exhibited the ability to enhance cell survival against viruses. In the HA assay, AG and EP extract showed good inhibitory effect on influenza A/B viruses. All of the samples demonstrated an improvement of the mitochondrial membrane potential and improved resistance to influenza A/B virus infection. EP and G. lucidum extracts at noncytotoxic concentrations increased cell viability, but only AG and EP extract directly decreased influenza virus titers. In conclusion, results indicate the ability of EP and G. lucidum extract to prevent viruses from entering cells by improving cell viability and mitochondrial dysfunction and EP extract showed direct inhibition on viruses and prevented viral infection at post-infection strategy.
PENGGUNAAN EXTREME PROGRAMMING dalam SISTEM PERSEDIAAN ATK pada SEKSI VERIFIKASI PRODUK NON UANG PERUM PERURI
Authors: Haryati Tri - , Sari Dita Auliana , Aprita Yessica Mega , Nuraeni Yuni Siti 
Published: July 2024

Sistem Persediaan sangatlah penting didalam suatu perusahaan. Sistem Persediaan membantu menghemat biaya, meningkatkan efesiensi, meningkatkan keamanan dan keselamatan data serta informasi pada perusahaan. Permasalahan Sistem Persediaan yang ada pada Seksi Verifikasi Produk Non Uang Perum Peruri adalah proses pencatatannya masih manual sehingga kurang Efisiensi waktu, Tidak bisa memprediksi kebutuhan barang yang akan digunakan dan tidak ada laporan persediaan, Sehingga dibutuhkan Sistem Informasi yang baik untuk menjawab permasalah tersebut. Pembangunan Sistem Informasi menggunakan Metode Extreme Programming sangatlah cocok dengan proyek sistem yang berskala kecil, karena extreme programming lebih adaptif, fleksibel, dan efisien sehingga lebih cepat dalam penyelesaian dan minim resiko. Adanya Sistem Informasi Persediaan dengan Model Pengembangan Extreme Programming memberikan kemudahan kepada pengguna karena pengembangan sistem sesuai dengan kebutuhan pengguna. Sistem Informasi Persediaan memudahkan pengguna dalam proses perhitungan stok barang dan kebutuhan barang dalam periode tertentu. Memudahkan dalam proses pembuatan laporan Persediaan. Pengujian sistem secara fungsional memiliki hasil 100% sesuai dengan harapan.

Kata kunci: Sistem Informasi, Persediaan, Extreme Programming
Canabidiol como opção terapêutica na Doença de Alzheimer
Authors: Aguiar Fabiana Teixeira , Barbosa Jéssica de Vasconcellos , Silva Lays Cristina da , Moura Marcela Maria Pereira de Lemos Pinto , Gonçales Juliana Prado 
Published: July 2024

A doença de Alzheimer é uma doença neurodegenerativa debilitante que afeta um número crescente de pessoas idosas. Os tratamentos atuais não interrompem nem revertem a progressão da doença, destacando a necessidade de terapêuticas novas e mais eficazes. Este estudo teve como objetivo abordar, mediante a uma revisão de literatura, o uso do canabidiol no tratamento do Alzheimer e seus aspectos da regulamentação brasileira. A revisão abrangeu estudos entre 2013 e 2023, sendo utilizadas bases de dados como Scielo, PubMed, MedLine e LILACS. O canabidiol demonstrou propriedades neuroprotetoras, anti-inflamatórias e antioxidantes in vitro, apresentando tanto efeitos corretivos como prevenindo o desenvolvimento de deficiências comportamentais relevantes para a doença de Alzheimer. Apesar de serem necessários mais estudos, os resultados das pesquisas apontaram benefícios terapêuticos quanto ao tratamento da Doença de Alzheimer com o uso do canabidiol.
Consumer Behavior of Households as a Sign of Classification of Subjects of the Russian Federation
Authors: Сафиуллина Е.А. , Янгирова Е.И. 
Published: July 2024

В статье проанализированы расходы на конечное потребление населения с помощью метода главных компонент по их структуре. Выявлено, что классификация субъектов РФ на основе анализа потребительского поведения домохозяйств, в частности, по структуре их расходов на конечное потребление, позволяет сгруппировать регионы для изучения уровня и качества жизни населения.
The article analyzes the expenditures on final consumption of the population using the method of principal components according to their structure. It was revealed that the possibility of classifying subjects of Russia on the basis of the formation of clusters related to consumer behavior of households, in particular the structure of their expenses, is necessary when studying the level and quality of life of the population, to analyze behavioral patterns and study factors that influence the transformation of these models.
Relationship between Innovation and Digital Economies
Authors: Машкина Д.И. , Хакимова Д.И. 
Published: July 2024

Статья посвящена проблеме идентификации инновационной и цифровой экономик. Рассмотрены актуальные подходы к их определению. На основе анализа существующих дефиниций предложены авторские трактовки данных понятий. Рассмотрены схожие и отличительные черты инновационной и цифровой экономик. Проведенный компаративный анализ позволил определить взаимосвязь данных экономик и предложить их иерархическую структуру.
The article is devoted to the problem of identification of innovative and digital economy. Actual approaches to their definition are considered. Based on the analysis of existing definitions, the authors interpretations of these concepts are proposed. Similar and distinctive features of innovative and digital economy are considered. The comparative analysis made it possible to determine the relationship of these economies and suggest their hierarchical structure.
Institutional Environment of Competition Policy Implementation
Authors: Россинская Г.М. , Еникеева Д.Д. 
Published: July 2024

В статье представлено различие между антимонопольной и конкурентной политикой. Отмечено, что на эффективность реализации конкурентной политики влияет институциональная среда. Выделены факторы, определяющие особенности институциональной среды в современной экономике. Показано влияние структурных, политических, социокультурных факторов на эффективность конкурентной политики, определены основные направления совершенствования современной институциональной среды конкурентной политики.
The article presents the difference between antitrust and competition policy. It is noted that the effectiveness of the implementation of competition policy is influenced by the institutional environment. The factors determining the features of the institutional environment in the modern economy are highlighted. The influence of structural, political, socio-cultural factors on the effectiveness of competition policy is shown, the main directions of improving the modern institutional environment of competition policy are determined.
Development of the Personnel Motivation and Incentive System
Authors: Алиева П.Р. , Гарунова Э.А. 
Published: July 2024

В статье рассматриваются актуальные проблемы развития системы мотивации и стимулирования труда персонала и основные методы развития и совершенствования управления системой мотивации труда персонала. Особое внимание уделяется зарубежным системам мотивации трудовой деятельности.
The article deals with the actual problems of development of the system of motivation and stimulation of personnel and the main methods of development and improvement of management of the system of motivation of personnel. Special attention is paid to foreign systems of motivation of labor activity.
Interdependence between Morbidity and Population Outflow in the Arctic Zone of Russia
Authors: Якушева У.Е. , Воронина Л.В. 
Published: July 2024

Статья посвящена исследованию взаимовлияния уровня заболеваемости и оттока населения на территории российской Арктики. Методом парной корреляции по шкале Чеддока определена теснота связи между выбывшим населением и уровнем заболевания болезнями органов дыхания, нервной, иммунной и эндокринной систем. По результатам проведенного анализа выявлено, что теснота связи дифференцирована по арктическим субъектам в зависимости от различных условий.
The article focuses on interaction between morbidity level and population outflow in the Arctic zone of Russia. Closeness of the relationship between the population outflow and morbidity level for diseases of the respiratory system, nervous, immune and endocrine systems is determined based on pair correlation method and the scale of Chaddock. The result of the analysis shows that the closeness of the relationship is distributed by Arctic regions depending on various conditions.
Efficiency of Use of Agricultural Production Potential оf the Republic оf Bashkortostan
Authors: Галиева Г.М. 
Published: July 2024

В данной статье на базе ресурсного и ресурсно-результативного подходов проведен анализ эффективности использования агропроизводственного потенциала. Выявлено, что с позиции оценки стоимостных показателей потенциал сельского хозяйства используется эффективно, с позиции оценки натуральных показателей неэффективно. Изучены основные факторы сложившегося положения в регионе. Проведено сравнение показателей Республики Башкортостан и регионов-лидеров Российской Федерации.
In this article on the basis of resource and resource-effective approaches the analysis of efficiency of use of agricultural production potential is carried out. It is revealed that from the position of evaluation of cost indicators the potential of agriculture is used effectively, from the position of evaluation of natural indicators is ineffective. The main factors of the current situation in the region are studied. The comparison of indicators of the Republic of Bashkortostan and the regions-leaders of the Russian Federation.
Valuation of Land Plots Using the Method of Qualimetry
Authors: Елкина Л.Г. , Галяутдинова Э.Ф. 
Published: July 2024

В статье представлены результаты теории и практики совершенствования методики оценки стоимости земельных участков с использованием квалиметрических моделей, позволяющих конвертировать качественные свойства объекта в количественные показатели.
The article presents the results of the theory and practice ofimproving the methodology for assessing the value of landusingqualimetricmodels to convert the qualitative properties of an object into quantitative indicators.
Development of a Methodological Approach to Conducting Internal Control of Receivables
Authors: Галеева Н.Н. 
Published: July 2024

В статье представлен методический подход к проведению внутреннего контроля дебиторской задолженности, который позволит оценить надежность партнеров как до вступления в деловые отношения, так и после совершения продаж, выполнения работ, оказания услуг.
The article presents a methodological approach to conducting internal control of receivables, which will assess the reliability of partners both before entering into business relations, and after making sales, performing work, and rendering services.