bluuebunny/crossref_metadata_2025_split huggingface dataset:
Groundwater inputs could be a significant but often overlooked source of phosphorus in lake ecosystems
Authors: Lisboa M. Sol , Schneider Rebecca L. , Rudstam Lars G. , Walter M. Todd 
Published: July 2024

AbstractFreshwater lakes are severely threatened, due largely to excess inputs of nutrients and other contaminants. Phosphorus (P) is receiving renewed attention due to recent increases in toxic cyanobacteria blooms in lakes worldwide. We investigated groundwater seepage for its role in P loading dynamics at Oneida Lake, New York, USA—one of the most well-studied lakes globally. P loading was measured at representative sites along the 88 km shoreline over three summers by directly measuring groundwater flow using seepage meters and porewater samplers. Groundwater seepage was a continuous and significant source of dissolved P over the summer months, comparable to tributary sources to the lake during that time. This constant input has enriched the concentrations of P in the nearshore surface waters, significantly above levels in the pelagic zone. Pore Total Phosphorus (TP) concentrations and loads reached extremely high values (up to 100 mg/L), with inorganic P representing only ~ 10% of TP per site. Groundwater seepage flows and P loadings were highly variable across space and time, partially explained by adjacent land uses and precipitation. Our research concludes that groundwater seepage is a significant, but overlooked, source of dissolved P and a crucial factor driving summer primary production at Oneida Lake, and likely other temperate lakes.
Performance and eye movement patterns of industrial design students reading sustainable design articles
Authors: Mao Yongchun , Han Yanjun , Li Puhong , Si Chengming , Wu Dan 
Published: July 2024

AbstractSustainable design education plays a crucial role in cultivating sustainability awareness and competencies among students studying industrial design. This research investigates their sustainability levels, reading performance when engaging with articles, and fixation patterns during reading. 60 industrial design students participated in the study. We evaluated their sustainability levels using the Sustainable Consumption Measurement Scale. After reading both theoretical and case article, they completed tests assessing their recall and perspective scores. We collected eye-tracking data to analyze fixation duration and conducted lag sequential analysis on fixation transitions. Students were categorized into higher and lower sustainability groups based on their sustainability scores. Female students demonstrated higher sustainability levels, and students with design experience performed better in the higher sustainability group. While recall scores did not differ significantly, the higher sustainability group exhibited elevated perspective scores in theory article. Perspective scores were generally higher for case article compared to theory article. The higher sustainability group exhibited longer fixation durations in theory article, while the case article had longer fixation durations on images. Fixation transition patterns varied between theoretical and case article, with the former featuring transitions from images to texts, and the latter demonstrating transitions between images. This study provides valuable insights into sustainable design education for students studying industrial design.
Quality of life of dermatology outpatients and its associated factors in Halibet National Referral Hospital in Asmara, Eritrea
Authors: Tewelde Tomas , Abdu Nuru , Weldemariam Dawit G. , Bereket Natnael , Russom Mulugeta , Tesfamariam Eyasu H. 
Published: July 2024

AbstractSkin diseases are prevalent globally and can have detrimental effects on the individual’s health-related quality of life (HRQoL). The treatment of dermatological patients typically focuses on clinical signs and symptoms and a subjective view of the impact of the disease on the patient’s life. Assessing quality of life can help provide patients with better service, by acknowledging their real needs and interfering with treatment decisions. The aim of the study was therefore to assess quality of life of dermatology outpatients and its associated factors. An analytical cross-sectional study was conducted in the dermatology clinic of Halibet National Referral Hospital in Asmara, Eritrea. HRQoL data were collected between May 6 and August 18, 2022 using a validated standard tool (Skindex-29). Descriptive statistics, logistic regression and paired t-test were employed using Statistical Package for Social Sciences (Version-26.0). A total of 375 dermatology clinic out-patients with a median age of 29 (Interquartile range: 25) were included in the study. The most commonly seen skin diseases were eczema, seborrhoeic dermatitis and tinea pedis. Emotion, symptom, and functioning domains of HRQoL were severely impaired in 75.7%, 50.4% and 57.6% of all dermatology outpatients, respectively. More than half of the respondents (57.9%) had a severely impaired overall HRQoL. In the overall HRQoL, being a rural resident [Adjusted Odds Ratio (AOR) 1.98, 95% CI 1.18, 3.33] and presence of chronic illness (AOR 2.16, 95% CI 1.22, 3.82) were significantly associated with severely impaired overall quality of life. A significantly higher mean score (p < 0.001) was observed in emotion [Mean (M) = 55.60, Standard Deviation (SD) = 21.0] as compared to functioning (M = 46.89, SD = 21.2). On the other hand, significantly higher mean score (p < 0.001) was observed on symptom (M = 54.08, SD = 20.5) as compared to functioning (M = 46.89, SD = 21.2). Skin diseases severely affected the emotion, functioning, and symptom domains of health-related quality of life. This highlights the importance of providing physical and psychosocial support to patients with dermatologic problems.
Detecting depression severity using weighted random forest and oxidative stress biomarkers
Authors: Bader Mariam , Abdelwanis Moustafa , Maalouf Maher , Jelinek Herbert F. 
Published: July 2024

AbstractThis study employs machine learning to detect the severity of major depressive disorder (MDD) through binary and multiclass classifications. We compared models that used only biomarkers of oxidative stress with those that incorporate sociodemographic and health-related factors. Data collected from 830 participants, based on the Patient Health Questionnaire (PHQ-9) score, inform our analysis. In binary classification, the Random Forest (RF) classifier achieved the highest Area Under the Curve (AUC) of 0.84 when all features were included. In multiclass classification, the AUC improved from 0.84 with only oxidative stress biomarkers to 0.88 when all characteristics were included. To address data imbalance, weighted classifiers, and Synthetic Minority Over-sampling Technique (SMOTE) approaches were applied. Weighted random forest (WRF) improved multiclass classification, achieving an AUC of 0.91. Statistical tests, including the Friedman test and the Conover post-hoc test, confirmed significant differences between model performances, with WRF using all features outperforming others. Feature importance analysis shows that oxidative stress biomarkers, particularly GSH, are top ranked among all features. Clinicians can leverage the results of this study to improve their decision-making processes by incorporating oxidative stress biomarkers in addition to the standard criteria for depression diagnosis.
Posttraumatic headache: pain related evoked potentials (PREP) and conditioned pain modulation (CPM) to assess the pain modulatory function
Authors: Jessen Julia , Höffken Oliver , Schwenkreis Peter , Tegenthoff Martin , Özgül Özüm Simal , Enax-Krumova Elena 
Published: July 2024

AbstractPosttraumatic headache (PTH) is common following traumatic brain injury and impacts quality of life. We investigated descending pain modulation as one possible mechanism for PTH and correlated it to clinical measures. Pain-related evoked potentials (PREP) were recorded in 26 PTH-patients and 20 controls after electrical stimulation at the right hand and forehead with concentric surface electrodes. Conditioned pain modulation (CPM) was assessed using painful cutaneous electric stimulation (PCES) on the right hand as test stimulus and immersion of the left hand into 10 °C-cold water bath as conditioning stimulus based on changes in pain intensity and in amplitudes of PCES-evoked potentials. All participants completed questionnaires assessing depression, anxiety, and pain catastrophising. PTH-patients reported significantly higher pain ratings during PREP-recording in both areas despite similar stimulus intensity at pain threshold. N1P1-amplitudes during PREP and CPM-assessment were lower in patients in both areas, but statistically significant only on the hand. Both, PREP-N1-latencies and CPM-effects (based on the N1P1-amplitudes and pain ratings) were similar in both groups. Patients showed significantly higher ratings for anxiety and depression, which did not correlate with the CPM-effect. Our results indicate generalized hyperalgesia for electrical stimuli in both hand and face in PTH. The lacking correlation between pain ratings and EEG parameters indicates different mechanisms of pain perception and nociception.
Promoting safety of underground machinery operators through participatory ergonomics and fuzzy model analysis to foster sustainable mining practices
Authors: Sakinala Vikram , Paul P. S. , Fissha Yewuhalashet 
Published: July 2024

AbstractOne of the most vital parameters to achieve sustainability in any field is encompassing the Occupational Health and Safety (OHS) of the workers. In mining industry where heavy earth moving machineries are largely employed, ergonomic hazards turn out to be significant OHS hazards causing Musculoskeletal Disorders (MSDs) in the operators. Nevertheless, the Indian mining industry lacks a comprehensive technique of OHS risk assessment, especially for ergonomic hazards that cause MSDs. This research appraises ergonomic hazards and develops Fuzzy Musculoskeletal-disorders Index (FMI) model to evaluate ergonomic-related MSDs. Work process and work tool ergonomic risk factors were identified through literature review and directives recommended by experts. Work posture was evaluated using RULA. The data-collecting approach was implemented using participatory ergonomic and design science principles. The FMI results show average MSDs score of 3.69, indicating high to extremely high risk. Surface plots show that combined work tool and work process was the most sensitive factors to MSDs risk compared to other two combinations. A two-sample t-test validated the FMI. The findings should help safety experts and managers develop effective OHS management plans and programmes for the sustainability of Indian mining industry.
Experimental system and method of aerobic thermal environment simulation based on laser heating
Authors: Wang Jiawei , Li Bin , Li Shengwu , Gao Sihao , Shen Yanlong , Wang Dahui , Yang Pengling 
Published: July 2024

AbstractConsidering the superior luminous intensity characteristics of lasers, a thermal simulation platform employing laser-induced heating in an aerobic environment was developed. Achieving a uniformly distributed flat-topped square laser beam output was facilitated through optical fibre bundling techniques, while precise control over laser power output was attained through current modulation. Utilising the aforementioned system, thermal shock simulation experiments were conducted in an aerobic environment, subjecting two types of high-temperature-resistant composites, namely C/C and C/SiC, to temperatures up to 1800 °C. These composites were lightweight, heat-resistant materials designed for hypersonic vehicle applications. The results show that the system and method can be used to simulate high temperatures, rapid temperature increases, and thermal shocks on C/C composite materials, with minimal variation in the coupling coefficient under aerobic conditions. The system and method can also provide key technology support for thermal-force-oxygen coupling testing of high temperature resistant materials.
Collective dynamics and pair-distribution function of active Brownian ellipsoids in two spatial dimensions
Authors: Bröker Stephan , te Vrugt Michael , Wittkowski Raphael 
Published: July 2024

AbstractWhile the collective dynamics of spherical active Brownian particles is relatively well understood by now, the much more complex dynamics of nonspherical active particles still raises interesting open questions. Previous work has shown that the dynamics of rod-like or ellipsoidal active particles can differ significantly from that of spherical ones. Here, we obtain the full state diagram of active Brownian ellipsoids in two spatial dimensions without hydrodynamic interactions depending on the Péclet number and packing density via computer simulations. The system is found to exhibit a rich state behavior that includes cluster formation, local polar order, polar flocks, and disordered states. Moreover, we obtain numerical results and an analytical representation for the pair-distribution function of active ellipsoids. This function provides useful quantitative insights into the collective behavior of active particles with lower symmetry and has potential applications in the development of predictive theoretical models.
Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
Authors: Lecoutre Simon , Maqdasy Salwan , Rizo-Roca David , Renzi Gianluca , Vlassakev Ivan , Alaeddine Lynn M. , Higos Romane , Jalkanen Jutta , Zhong Jiawei , Zareifi Danae S. , Frendo-Cumbo Scott , Massier Lucas , Hodek Ondrej , Juvany Marta , Moritz Thomas , de Castro Barbosa Thais , Omar-Hmeadi Muhmmad , López-Yus Marta , Merabtene Fatiha , Abatan Jimon Boniface , Marcelin Geneviève , El Hachem Elie-Julien , Rouault Christine , Bergo Martin O. , Petrus Paul , Zierath Juleen R. , Clément Karine , Krook Anna , Mejhert Niklas , Rydén Mikael 
Published: July 2024

AbstractGlutamine and glutamate are interconverted by several enzymes and alterations in this metabolic cycle are linked to cardiometabolic traits. Herein, we show that obesity-associated insulin resistance is characterized by decreased plasma and white adipose tissue glutamine-to-glutamate ratios. We couple these stoichiometric changes to perturbed fat cell glutaminase and glutamine synthase messenger RNA and protein abundance, which together promote glutaminolysis. In human white adipocytes, reductions in glutaminase activity promote aerobic glycolysis and mitochondrial oxidative capacity via increases in hypoxia-inducible factor 1α abundance, lactate levels and p38 mitogen-activated protein kinase signalling. Systemic glutaminase inhibition in male and female mice, or genetically in adipocytes of male mice, triggers the activation of thermogenic gene programs in inguinal adipocytes. Consequently, the knockout mice display higher energy expenditure and improved glucose tolerance compared to control littermates, even under high-fat diet conditions. Altogether, our findings highlight white adipocyte glutamine turnover as an important determinant of energy expenditure and metabolic health.
Evaluating the near- and long-term role of carbon dioxide removal in meeting global climate objectives
Authors: Ganti Gaurav , Gasser Thomas , Bui Mai , Geden Oliver , Lamb William F. , Minx Jan C. , Schleussner Carl-Friedrich , Gidden Matthew J. 
Published: July 2024

AbstractThe 6th Assessment Report from the Intergovernmental Panel on Climate Change lacked sufficient land-sector scenario information to estimate total carbon dioxide removal deployment. Here, using a dataset of land-based carbon dioxide removal based on the scenarios assessed by the Intergovernmental Panel on Climate Change, we show that removals via afforestation and reforestation play a critical near-term role in mitigation, accounting for around 10% (median) of the net greenhouse gas emission reductions between 2020 and 2030 in scenarios that limit warming to 1.5 °C with limited overshoot. Novel carbon dioxide removal technologies such as direct air carbon capture and storage scale to multi-gigatonne levels by 2050 and beyond to balance residual emissions and draw down warming. We show that reducing fossil fuel and deforestation emissions (gross emissions) accounts for over 80% of net greenhouse gas reductions until global net zero carbon dioxide (CO2) independent of climate objective stringency. We explore the regional distributions of gross emissions and total carbon dioxide removal in cost-effective mitigation pathways and highlight the importance of incorporating fairness and broader sustainability considerations in future assessments of mitigation pathways with carbon dioxide removal.
Implementing the analogous neural network using chaotic strange attractors
Authors: Kesgin Bahadır Utku , Teğin Uğur 
Published: July 2024

AbstractMachine learning studies need colossal power to process massive datasets and train neural networks to reach high accuracies, which have become gradually unsustainable. Limited by the von Neumann bottleneck, current computing architectures and methods fuel this high power consumption. Here, we present an analog computing method that harnesses chaotic nonlinear attractors to perform machine learning tasks with low power consumption. Inspired by neuromorphic computing, our model is a programmable, versatile, and generalized platform for machine learning tasks. Our mode provides exceptional performance in clustering by utilizing chaotic attractors’ nonlinear mapping and sensitivity to initial conditions. When deployed as a simple analog device, it only requires milliwatt-scale power levels while being on par with current machine learning techniques. We demonstrate low errors and high accuracies with our model for regression and classification-based learning tasks.
CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes
Authors: Cao LuYan , Huang Shaina , Basant Angika , Mladenov Miroslav , Way Michael 
Published: July 2024

AbstractThe inhibitors, CK-666 and CK-869, are widely used to probe the function of Arp2/3 complex mediated actin nucleation in vitro and in cells. However, in mammals, the Arp2/3 complex consists of 8 iso-complexes, as three of its subunits (Arp3, ArpC1, ArpC5) are encoded by two different genes. Here, we used recombinant Arp2/3 with defined composition to assess the activity of CK-666 and CK-869 against iso-complexes. We demonstrate that both inhibitors prevent linear actin filament formation when ArpC1A- or ArpC1B-containing complexes are activated by SPIN90. In contrast, inhibition of actin branching depends on iso-complex composition. Both drugs prevent actin branch formation by complexes containing ArpC1A, but only CK-869 can inhibit ArpC1B-containing complexes. Consistent with this, in bone marrow-derived macrophages which express low levels of ArpC1A, CK-869 but not CK-666, impacted phagocytosis and cell migration. CK-869 also only inhibits Arp3- but not Arp3B-containing iso-complexes. Our findings have important implications for the interpretation of results using CK-666 and CK-869, given that the relative expression levels of ArpC1 and Arp3 isoforms in cells and tissues remains largely unknown.
Exploring Interactive Songs as a Vocabulary Input Context
Authors: Grissom Alaina , Finke Erinn H. 
Published: July 2024

Purpose:
Interactive songs are a common shared activity for many families and within early childhood classrooms. These activities have the potential to be rich sources of vocabulary input for children with and without language impairments. However, little information is known about the how caregivers currently provide input for different types of vocabulary during these activities. The purpose of this research note is to provide preliminary information on how caregivers provide input related to verbs within an interactive song activity.

Method:
Observations of caregivers engaging in song activities with their child were collected. The gestures used during the interactions were coded.

Results:
The results show that, when given examples, caregivers provide gestural input both frequently and consistently.

Conclusions:
Clinical implications and future directions for exploring songs as an intervention context are discussed.
Reduction of losses in dual‐permanent‐magnet‐excited Vernier machine by segmented stator for electric aircraft
Authors: Ji Jinghua , Jia Chen , Zhao Wenxiang , Ling Zhijian , Zeng Yu , Li Zongwang 
Published: July 2024

AbstractThe authors present a low‐loss dual‐permanent‐magnet‐excited vernier (DPMEV) machine with segmented stator design to meet the requirements of low iron loss of electric aircraft based on the field modulation theory. The stator topology features and losses of both the original and segmented DPMEV machines are comparatively investigated. Then, the armature air‐gap flux density is deduced by the magnetic motive force‐permeance model, and the influence of each harmonic on the losses are analysed. It is found that the harmonic which produces losses in the original machine reduced greatly after introducing the segmented structure. Furthermore, the electromagnetic performances of two DPMEV machines are comparatively analysed by finite element analysis. Finally, two prototypes of the original and segmented DPMEV machines are built and tested to verify the theoretical analysis.
Ursachen und Wirkung des strukturellen Finanzierungsdefizits in der
gesetzlichen Krankenversicherung
Authors: Keutel Christian 
Published: July 2024

ZusammenfassungDie Finanzlage der gesetzlichen Krankenversicherung zeigt in den vergangenen vier
Jahren eine ansteigende milliardenschwere Finanzierungslücke. Ursächlich hierfür
sind die Ausgaben, die schneller als die Einnahmen steigen. Der Artikel
analysiert mit einer Prognose auf Basis einer linearen Trendextrapolation
(statistische Zeitreihenanalyse) die Wirkungsweise der aktuellen politischen
Maßnahmen für das Jahr 2023. Er kommt zu dem Schluss, dass der durchschnittliche
Zusatzbeitragssatz einmalig durch den Maßnahmenmix der Politik, bestehend aus
einer kurzfristigen Veränderung des Einnahmendefizites in Höhe von ca. 10,2 Mrd.
Euro sowie eine Ausgabenreduzierung um ca. 3,8 Mrd. Euro stabilisiert werden
kann. Für das Jahr 2024 besteht weiterhin ein Handlungsbedarf, um die
Finanzierungslücke dauerhaft zu schließen.