bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and economic analysis of the use of the medicinal product dapagliflozin in patients with chronic heart failure and type 2 diabetes mellitus
Authors: Zhuravleva M. V. , Gagarina J. V. , Marin T. V. 
Published: July 2024

OBJECTIVE: Clinical and economic evaluation of using the dapagliflozin in addition to standard therapy for patients with CHF (Chronic Heart Failure) and concomitant type 2 DM (Diabetes mellitus).MATERIALS AND METHODS: All adult Russian patients with confirmed diagnosis of CVD and concomitant type 2 DM were considered as the target population. We evaluated the use of dapagliflozin in addition to standard therapy in comorbid patients with CHF and DM type 2 on the indicators of CC death, death from any cause of hospitalization due to CHF, emergency treatment due to CHF, as well as calculated the cost per life year saved and quality-adjusted life year (QALY) saved both when using standard therapy alone and in combination with dapagliflozin.RESULTS: The use of dapagliflozin in addition to standard therapy for the treatment of comorbid patients with CHF and DM 2 per cohort of 1,000 people will prevent an additional 1,3 and 10 years:CHD-related hospitalizations: 40, 99, 195, respectively;Emergency admissions due to CVD: 15, 38, 73 respectively;CC deaths: 9, 19, 25 respectively;Deaths from any cause: 10, 21, 19At the same time, the costs per one year of quality-adjusted life saved were 1,923,509 rubles during the first year, 1,102,680 rubles during the first 3 years, and 560,841 rubles for 10 years, which did not exceed the calculated value of the willingness-to-pay threshold — 3.14 million rubles, and allowed us to conclude that dapagliflozin is clinico-economically feasible in the studied patient population.CONCLUSION: The use of dapagliflozin in addition to standard therapy for the treatment of comorbid patients with CHF and type 2 diabetes is clinically and economically feasible, considering the cost per year of life saved, adjusted for quality of life.
Top-Down Corruption of Consciousness
Authors: Studt S.J. Eric 
Published: July 2024

Abstract
Collingwood argues that art is a remedy for what he calls a “corrupt consciousness.” Consciousness becomes corrupted when agents do not admit that they are starting to experience an emotion. Instead of becoming conscious of the emerging emotion, which is usually a difficult one, agents become conscious of an emotion that is easier to handle. Collingwood sees the corruption of consciousness as epistemically and morally problematic mainly because it is a form of dishonesty that infects the activity of the imagination and the intellect. While highlighting the importance of Collingwood’s notion of the corruption of consciousness, this paper argues that this notion would benefit from being situated in an explicitly top-down model of attention and emotion as opposed to the bottom-up model that Collingwood proposes. This shift preserves the central insights of Collingwood’s aesthetics – most especially his emphasis on the specificity involved in the expression of emotion – while ironing out some of the implausibility in his underlying analysis.
Effects of Zr additions and process annealing on mechanical and corrosion properties of AA5383 Al–Mg alloys
Authors: Hsu Chin-Wei , Lee Sheng-Long , Kuo Ping-Chih , Wu Chih-Ting 
Published: July 2024

Abstract
The study investigates how Zr additions and process annealing affect mechanical and corrosion properties of AA5083 Al–Mg alloys by microstructural examination, tensile strength, hardness testing and ASTM G67 nitric acid mass loss test. In the present work, process annealing temperatures were set to 220 °C and 250 °C. The results show that the hardness and tensile properties of Zr-containing cold rolled alloy were superior to that of Zr-free cold rolled alloy before and after process annealing treatment and sensitization heat treatment. Unfortunately, adding Zr to AA5383 alloy significantly degraded the corrosion resistance of the Zr-containing cold rolled alloy annealed at 220 °C. For improving corrosion resistance of Zr-containing alloy, annealing temperature could be increased to 250 °C to avoid a marked drop in the corrosion resistance.
Boanmycin induces apoptosis and overcomes venetoclax resistance in acute myeloid leukemia
Authors: Wang Jin-Xing , Zhang Peng-Wei , Yuan Luo-Wei , Jiang Jian , Cheng Xiao-Hui , Li Ju-Heng , Tang Mei-Qin , Fan Jiao-Yang , Zhu Wei , Lei Yong , Tian Fa-Qing 
Published: July 2024

Abstract

Objectives
This study aimed to investigate the efficacy of boanmycin, a clinical drug used for head and neck cancers, in the treatment of acute myeloid leukemia (AML), particularly in venetoclax-resistant AML cells.

Methods
The cell viability assay was conducted to measure the inhibitory effects of boanmycin on the AML cell lines and patient primary cells using the CCK8 reagent. The colony formation assay was performed to evaluate the colony formation ability of HL60 and venetoclax-resistant HL60 (HL60-res) cells with or without boanmycin treatment. Flow cytometry was performed to detect cell apoptosis level, and Western blot was used to assess changes in apoptosis-related proteins.

Results
Our findings reveal that boanmycin significantly inhibits AML cell proliferation and colony formation, and induces apoptosis. Importantly, boanmycin exhibits substantial inhibitory effects on venetoclax-resistant cells, and suppresses the proliferation of peripheral blood mononuclear cells (PBMCs) or bone marrow mononuclear cells (BMMCs) derived from newly diagnosed and relapsed AML patients.

Conclusions
Boanmycin may overcome venetoclax resistance and offer therapeutic benefits for patients with venetoclax-resistant AML.
Publishing Trends of Informal Lithuanian Youth Publications –Fanzines – at the End of the 20th Century and the Beginning of the 21st Century
Authors: Kairaitytė-Užupė Aušra 
Published: July 2024

This article analyzes Lithuanian youth subcultural group publications – fanzines (zines) – which have not yet received broader attention from researchers. Paper fanzines started to be created at the end of the 20th century and became popular in the 1990s, spreading Western culture ideas and changing the political, and socio-cultural environment in Lithuania along with technological copying and reproduction possibilities.
Using resources from Lithuania’s Youth Culture Digital Archive “Lithuanian Zine Collection” and additionally collected sources, the article analyzes the trends in the creation and publishing of fanzines. By comparing the publishing similarities and differences of fanzines attributed to different subcultural groups, the aim is to understand the cultural context of these publications, their relationship with readers, and the publishing possibilities of fanzine creators.
The study applies descriptive metadata analysis and systematization of fanzines, as well as ethnographic research methods (targeted interview, questionnaire, and qualitative interviews with fanzine authors, publishers, and collectors).
The research results showed that in Lithuania, mainly in the 1990s, metal music fanzine authors, unlike punks and science fiction fans, created more publications written in English. Metal music fanzines were characterized by greater volume. Science fiction fans’ publications differed from those of metalheads and punks by a greater number of continuous issues and fewer one-time publications. Authors of fanzines associated with punk ideology mostly chose to independently reproduce publications using a copying machine, while creators of metal music and science fiction fanzines more often used professional printing services.
The language used in fanzines and its style helped to form a close relationship with readers, revealed the identity traits of subcultural groups, and helped metal music fanzine authors to integrate into the international fanzine culture context. Seeking independence and individuality, fanzine creators disregarded professional publishing standards. Fanzine publishing depended on individual choice, motivation, creativity, reader interest, and technological possibilities (publication reproduction, layout). Fanzines created in Lithuania became one of the main forms of idea dissemination, creative freedom, and self-expression for alternative youth communication.
Two-Sided Convexity Testing with Certificates
Authors: Dumitrescu Adrian 
Published: July 2024

We revisit the problem of property testing for convex position for point sets in ℝ𝑑. Our results draw from previous ideas of Czumaj, Sohler, and Ziegler (2000). First, their testing algorithm is redesigned and its analysis is revised for correctness. Second, its functionality is expanded by (i) exhibiting both negative and positive certificates along with the convexity determination, and (ii) significantly extending the input range for moderate and higher dimensions.The behavior of the randomized tester on input set 𝑃 ⊂ ℝ𝑑 is as follows: (i) if 𝑃 is in convex position, it accepts; (ii) if 𝑃 is far from convex position, with probability at least 2/3, it rejects and outputs a (𝑑 +2)-point witness of non-convexity as a negative certificate; (iii) if 𝑃 is close to convex position, with probability at least 2/3, it accepts and outputs a subset in convex position that is a suitable approximation of the largest subset in convex position. The algorithm examines a sublinear number of points and runs in subquadratic time for every fixed dimension 𝑑.
The Ornamental Plant Sector and Ornamental Plant Producers During the COVID-19 Pandemic (Cultural Responses to a Pandemic Situation in a Production Setting in East Central Europe)
Authors: Nagy Zsolt 
Published: July 2024

AbstractOn March 24, 2020, the international flower trade association Union Fleurs issued a statement on the situation of the ornamental plants sector hit by the Covid-19 crisis. In a study published in April 2020, Copa-Cogeca (European Farmers and European Agri-Cooperatives) echoed the findings of the above-mentioned international flower trade association, stating that the flower and ornamental plants sector was the agricultural sector most impacted by the coronavirus in the EU, as in most Member States, including Hungary and Romania, there was a historical drop in demand and consumption of almost 80%, and unfortunately the virus hit at the worst possible time, as the spring season would have been the peak period for ornamental horticulturalists. In my case study, I examine the flower growers of Curteni, a settlement in the Mureș region of Transylvania (Romania). How has this global phenomenon caused by the coronavirus manifested itself locally in a settlement where nearly 60 families make their living from growing and selling ornamental plants? Has this community been able to maintain its territorial/regional competitiveness? Have the people of Curteni joined the group of producers known in economic anthropology as farmers who chose to halt and wait, or did they find a quick and resilient response to the obstacles they encountered? How did this crisis become an identity-shaping factor in their lives? The pandemic has also exacerbated the situation in Curteni, made it more difficult to act and make decisions, and has brought new perspectives and values into play. The example of the florist community of Curteni shows that a new situation, and indeed any crisis, can bring about positive changes in the lives of communities. In any crisis, emergency, or exigency, members of a community may almost instinctively, but mostly also consciously, seek innovative responses to their problems. One way is to discover and exploit the opportunities inherent in a crisis, communally re-assessing and utilizing the available values, opportunities, and resources, and finding truly resilient responses.
Interacción en diferentes contextos socioculturales para la formación crítica de docentes de lenguas
Authors: Huerta Cordova Vilma , Valtierra-Zamudio Jorge , López-Gopar Mario Enrique 
Published: July 2024

Objetivo.
Analizar la experiencia/aprendizaje de estudiantes de la Licenciatura en Enseñanza de Idiomas, partiendo de una investigación para comprender una educación en la praxis desde una visión crítica en un entorno distinto al del aula. Metodología. Este artículo deriva de una investigación que realizaron 5 estudiantes que cursaban la asignatura de metodología de la investigación. Hicieron entrevistas a algunos albañiles que trabajaban en una universidad pública en Oaxaca (México). A partir de esta actividad, los estudiantes manifestaron algunas experiencias que en este artículo se analizan desde una visión crítica e intercultural en materia educativa. Se utilizó un enfoque cualitativo y el grupo focal para la recolección de datos; después se hizo un análisis para identificar temas emergentes conectados con la formación docente de los estudiantes dentro de un programa con visión crítica e intercultural. Resultados. Se apunta a la necesidad de visibilizar(nos) dentro de los espacios en los que interactuamos; cuestionar las visiones deficitarias que se tienen del otro, y buscar la justicia social en el trabajo docente y de construcción. Conclusiones. Los futuros enseñantes de idiomas, al dialogar con personas de otros contextos socioculturales, desarrollan un pensamiento reflexivo que hace que replanteen sus creencias y amplíen su perspectiva sobre los otros, incidiendo positivamente en su formación docente. Implicaciones. Los currículos educativos enfocados en la formación de profesores de lenguas que guardan una visión crítica e intercultural deben proporcionar elementos teóricos de las aproximaciones críticas e interculturales, pero también prácticas en donde los futuros enseñantes puedan reflexionar sobre estos conceptos.
Pelatihan Strategi Bisnis Berkelanjutan di Era Pandemi Covid-19 bagi Start-Up Business
Authors: Mindarta Erwin Komara , Lubis Didin Zakaria , Irawan Dani , Utomo Eko Prastyo , Priyananda Esa Arijuna 
Published: July 2024

Diagnostic Tool merupakan alat diagnosa profesional yang digunakan oleh seorang mekanik atau teknisi kendaraan termasuk sepeda motor yang berfungsi untuk menemukan kerusakan pada motor injeksi dengan cara scanning data yang tersimpan di dalam memori ECU. Di Universitas Negeri Malang (UM), bengkel motor yang memiliki standart bengkel resmi belum banyak, termasuk bengkel Sinar Mustika Motor. Tim pelaksana pengabdian kepada masyarakat dari Jurusan Teknik Mesin UM menjawab kebutuhan mitra, dengan memberikan solusi Inovasi teknologi Diagnostic Tool Motor Injeksi Versi Android. Untuk mencapai tujuan pengabdian, prosedur yang ditempuh meliputi 1) survey lokasi, 2) pendekatan sosial, 3) pengembangan produk, 4) penyusunan panduan, 5) penerapan ipteks/TTG melalui kegiatan introduksi alat dan pelatihan; 6) tindak lanjut melalui pendampingan; 7) monev, dan 8) memenuhi kewajiban luaran. Hasil PKM-LK: 1) produk berfungsi dengan baik serta bermanfaat bagi pemakainya: a) dapat membaca, mereset code dan memanipulasi data konsumsi BBM agar lebih irit, b) dapat mengetahui masalah kerusakan pada motor injeksi, c) dapat menemukan kerusakan pada motor dengan cara scanning data yang tersimpan di dalam memori ECU; dan 2) dapat digunakan sebagai usaha diagnosis awal kerusakan pada sistem sepeda motor secara mandiri di Bengkel Sinar Mustika Motor. Kata kunci— Diagnostic, Motor injeksi, Android Abstract Diagnostic Tool is a professional Diagnostic tool used by a mechanic or vehicle technician including motorcycles that serves to find damage to the injection motor by scanning the data stored in the ECU memory. Diagnostic Tool is usually owned by a motorcycle repair shop that has an official workshop standard. Around Universitas Negeri Malang (UM), there are not many motorcycles repair shops that have official workshop standards, including Sinar Mustika Motor workshops. The community service implementation team from the Department of Mechanical Engineering, UM answered the needs of partners, by providing innovative solutions for the Android Version of Injection Motor Diagnostic Tool technology. To achieve the goal of service, the procedures taken include 1) site survey, 2) social approach, 3) product development, 4) preparation of guidelines, 5) application of science and technology/TTG through tool introduction and training activities; 6) follow-up through mentoring; 7) monev, and 8) fulfill external obligations. PKM-LK results: 1) the product functions properly and is useful for the user: a) can read, reset code and manipulate fuel consumption data to make it more efficient, b) can find out the problem of damage to the injection motor, c) can find damage to the motor by how to scan data stored in the ECU memory; and 2) can be used as an effort to independently diagnose damage to the motorcycle system at the Sinar Mustika Motor Workshop. Keywords— Diagnostic, Injection motor, Android
Evaluation of pleural ?uid cytology for the diagnosis of pleural effusion: A retrospective study
Authors: Patel Jaiminkumar Mahendrabhai , Contractor Tejas Atulbhai , Dayal Anupama Ishwar , Agrawal Sandesh Omprakash , Patel Hani Kamleshbhai 
Published: July 2024

Cytological examination of pleural ﬂuid has good speciﬁcity for the diagnosis of malignant pleural effusion (MPE). (1). To study the incidence of non-neoplastic and neoplastic effusions; (2). To study most common cause of neoplastic effusions.This study is an Observational retrospective study that was conducted from April 2021 to October 2022 (1.5 years). This study was conducted in the Cytology section, Pathology Department, of a tertiary care centre, Gujarat, India. A total of 248 pleural fluid samples were studied among them 186 were benign effusions, 48 were malignant effusions, 10 cases were unsatisfactory for evaluation and 4 cases were suspicious for malignancy.A descriptive study was performed to know the incidence of benign and malignant effusion in the pleural fluid sample. Pneumonia was the most common clinical diagnosis followed by tuberculosis and malignancy. Lung was the most common primary site for pleural effusion. In females, ovarian carcinoma was the primary aetiology followed by breast carcinoma. Cytodiagnosis of pleural fluid represents the cell population from a much larger representative area than obtained from the needle biopsy.
Exploring bacterial profiles and antibiotic susceptibility patterns in urinary tract infection cases at Idlib university hospital, Syria
Authors: Mushtaq Gohar Hussain , Al-Daoud Fouad 
Published: July 2024

The main objective of this study was to identify, analyze, and evaluate the bacteriological profile and antimicrobial susceptibility patterns of symptomatic urinary tract infections (UTIs) among patients at Idlib University Hospital in Northwest Syria. By isolating and characterizing the uropathogens, the study aimed to gain insights into their current antimicrobial susceptibilities. This information is crucial in order to combat the increasing antibiotic resistance and provide effective treatment options for UTIs, which are prevalent both in the community and hospital settings.This observational research took place at Idlib University Hospital in Northwest Syria spanning from June 2022 to December 2023. Our study involved 320 patients exhibiting symptoms of UTI (68.4% females and 31.6% males). Urine samples were cultured to identify the microorganisms responsible for UTI. Biochemical tests were employed to identify the isolated bacteria, while the antimicrobial susceptibility was determined through disk diffusion susceptibility testing. Our study found to be the leading cause of UTIs, accounting for 58.4% of cases, followed by spp. Gram-negative bacteria comprised 85% of isolated strains. The 13–65 age group showed the highest UTI susceptibility (41.3%). High resistance was observed to ampicillin/sulbactam, cefotaxime, ceftriaxone, and co-trimoxazole. Conversely, minimal resistance was noted against Meropenem, Imipenem, Gentamicin, and Levofloxacin.This research highlights the prevalence of antibiotic-resistant infections within the hospital under study. Hence, there is an imperative to enhance the efficiency of comprehensive infection control initiatives to effectively handle and regulate hospital-acquired infections caused by highly resistant microorganisms.
PCR-based detection and mutation dynamics of fusion protein gene of orthoaviula viruses sequestered during 2023 field outbreaks in Pakistan
Authors: Mehmood Muhammad Danish , Anwar ul-Haq Huma , Tariq Rida , Fayyaz Ahad , Ameen Faisal , Sharif Nadeem 
Published: July 2024

: To isolate and detect a Newcastle disease virus in commercial poultry, Molecular characterization and phylogenetic analysis of the confirmed isolate and Multiple sequence alignment and achievement of accession numbers against our submissions in NCBI bankit.: Genetic and antigenic diversity in the fusion protein gene of New Castle disease virus strains has been recognized and the progressive changes over sequential years indicate that it is a continuously evolving virus. The current vaccines containing conventional vaccinal strains can protect birds to a certain level but do not prevent infection and virus shedding. : The partial fusion protein gene of the 14 NDV isolates during the 2023 outbreaks from different areas of Pakistan was determined and analyzed. The antigenic protein translational segment of the fusion gene nucleotide fragment was targeted with a specifically designed primer executed 202 bp size of predictable amplicon during PCR amplification. The nucleotide sequence analysis of studied isolates showed closed similarity to the NCBI bankit numbers. Phylogenetic analysis revealed that 3 isolates belong to genotype II while, 2 isolates positions near genotype VIII of class II. The 6 isolates were located near genotype XVII and only 1 was presented on genotype V branch in calss II. Mutation analysis results revealed various mutations at nucleotide intervals and even found altered amino acids during translation. The results revealed that nucleotide mutation at various positions attributes amino acid substitution that enables wild prevailing strains to evade artificial active immunity. In such a scenario Chimeric and genotype match vaccines prepared from indigenous isolates may be useful in developing candidate vaccines to prevent virus shedding and infection. Further studies are suggested at molecular level to determine the consensus amino acid sequence for virulent, mesogenic, and avirulent prevailing NDV strains.
Motives for parenthood, psychosocial factors and health in women undergoing IVF: A systematic review
Authors: Chatzopoulou Dimitra , Sarantaki Antigoni , Gourounti Kleanthi 
Published: July 2024

IntroductionInfertility affects 8-12% of reproductive-age couples globally, leading to significant psychosocial challenges. This review explores the psychological aspects of in vitro fertilization (IVF) treatment and its impact on mental well-being.MethodsA systematic review of 13 studies was conducted using Google Scholar, Tandfonline, Medrxiv, and PubMed. Inclusion criteria included studies on women aged 18-50 undergoing IVF, focusing on psychosocial and health factors, published in English or Greek.ResultsWomen undergoing IVF reported increased anxiety during the second and third trimesters. Psychological interventions, such as hope-oriented group counseling, improved mental health and quality of life. Patient satisfaction with IVF was generally high, influenced by demographic variables and psychological factors. Higher stress levels were linked to lower IVF success rates. The COVID-19 pandemic exacerbated psychological distress and treatment delays.ConclusionsAddressing psychological well-being in IVF is crucial. Integrating psychological support, counseling, and stress management interventions can enhance patient experience, improve treatment outcomes, and promote overall mental health. Further research is needed to develop tailored interventions that address the unique needs of individuals undergoing IVF.