bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of iron status on gadolinium deposition in the rat brain: mechanistic implications
Authors: Prybylski John P. , Jastrzemski Olivia , Jay Michael 
Published: August 2024

Introduction: Sites associated with gadolinium (Gd) deposition in the brain (e.g., the globus pallidus) are known to contain high concentrations of ferric iron. There is considerable debate over the mechanism of Gd deposition in the brain. The role of iron transport mechanisms in Gd deposition has not been determined. Thus, we seek to identify if Gd deposition can be controlled by modifying iron exposure.Methods: Female Sprague-Dawley rats were given diets with controlled iron levels at 2–6 ppm, 6 ppt (20 g/kg Fe carbonyl) or 48 ppm for 3 weeks to induce iron deficiency, overload or normalcy. They were kept on those diets while receiving a cumulative 10 mmol/kg dose of gadodiamide intravenously over 2 weeks, then left to washout gadodiamide for 3 days or 3 weeks before tissues were harvested. Gd concentrations in tissues were analyzed by ICP-MS.Results: There were no significant effect of dietary iron and total Gd concentrations in the organs, but there was a significant effect of iron status on Gd distribution in the brain. For the 3-week washout cohort, there was a non-significant trend of increasing total brain deposition and decreasing dietary iron, and about 4-fold more Gd in the olfactory bulbs of the low iron group compared to the other groups. Significant brain accumulation was observed in the low iron group total brain Gd in the 3-week washout group relative to the 3-day washout group and no accumulation was observed in other tissues. There was a strong negative correlation between femur Gd concentrations and concentrations in other organs when stratifying by dietary iron.Discussion: Gd brain deposition from linear Gd-based contrast agents (GBCAs) are dependent upon iron status, likely through variable transferrin saturation. This iron dependence appears to be associated with redistribution of peripheral deposited Gd (e.g., in the bone) into the brain.
Transcriptional Profiling and Key Enzyme Activity of Epichloë sinensis Isolated from Festuca sinensis in Response to Na2SeO3
Authors: Zhou Lianyu , Liu Yu , Ma Yun , Qiao Feng , Xie Huichun , Luo Qiaoyu 
Published: August 2024

Fungal endophytes exhibit symbiotic relationships with their host plants and convert inorganic selenium to organoselenium and Se0. In order to elucidate how Epichloë sinensis from Festuca sinensis adapts to different concentrations of sodium selenate, the dynamic changes of mycelial enzyme activities and metabolic changes at the transcriptional level were documented over a period of 36 h. The activity of enzymes (superoxide dismutase, glutathione reductase, glutathione S-transferase, cysteine synthetase, and methionine synthesis) in mycelia increased in the presence of increased Se concentrations during the cultivation period. The strain with selenium enrichment showed differential changes in gene expression compared to the strain without selenium enrichment, with more changes observed at higher Se concentrations over time. Notably, genes related to ribosomes or ribosome biogenesis in eukaryotes showed significant expression differences among certain groups, with up-regulation of genes involved in oxidoreductase activity, superoxide dismutase, and siderophore biosynthetic processes, and down-regulation of genes involved in steroid biosynthesis. These findings contribute to a better understanding of the transcriptional response of Epichloë sinensis to selenium.
Exploring the Relationship between Cerebral Palsy and Hip Dysplasia: Insights from the National Inpatient Sample
Authors: Alyoubi Reem Abdullah , Alyahyawi Huda Yahya , Alsharief Abrar Nayel , Alahmadi Ghadeer Ghazi , Althubaiti Faris , Basheikh Mazen A. , Alhifthy Elham H. , Abu-Zaid Ahmed 
Published: August 2024

Background and Objective: Cerebral palsy (CP) significantly impacts quality of life globally. Hip dysplasia (HD) is a common musculoskeletal issue in CP patients. This study investigates the prevalence, risk factors, and impact of HD on CP patients using a large national database. Materials and Methods: Data from the National Inpatient Sample (NIS) database (2016–2019) were used, identifying CP and HD diagnoses through ICD-10 codes. Baseline characteristics were tabulated. Univariate and multivariate logistic regression analyses examined predictors of HD development in CP patients, presenting data as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Among 3,951,040 pediatric patients, 28,880 had CP (27,466 without HD, and 1414 with HD), and 3,922,160 did not have CP. CP significantly increased the likelihood of developing HD in univariate (OR = 35.03, 95% CI [33.01, 37.17], p < 0.0001) and multivariate (OR = 26.61, 95% CI [24.94, 28.40], p < 0.0001) analyses. Among patients with CP, race was significantly associated with HD, with ORs below 1 for all racial categories compared to Whites. Females had nearly twice the odds of HD compared to males (OR = 1.96, 95% CI [1.86, 2.05], p < 0.0001). Age was significantly associated with HD, with each additional year increasing the odds (OR = 1.03, 95% CI [1.026, 1.034], p < 0.0001). Individuals in the high 51st–75th income quartile had a 17% increase in the odds of HD (OR = 1.17, 95% CI [1.09, 1.25], p < 0.0001) compared to the low 1st–25th income quartile. Conclusions: This study reinforces the strong association between CP and HD, highlighting the need for further research and prospective studies to validate these findings.
SIFAT ORGANOLEPTIK DAN NILAI GIZI PUDING U-BANSOY (ULI BANANA SOYA) SEBAGAI ALTERNATIF SELINGAN TINGGI KALIUM DAN ISOFLAVON
Authors: Nurhotimah Enung , Aeni Muna Nur , Gumilar Mulus , Fitria Mona , Judiono Judiono , Mulyo Gurid Pramintarto Eko 
Published: August 2024

Uli bananas contain higher potassium than other types of bananas. Soybeans can help lower blood pressure in hypertensive patients through potassium content and antioxidant activity, as shown by isoflavones. This study aimed to determine the organoleptic properties and nutritional value of U-Bansoy Pudding with soybean and banana formulations as an alternative high-potassium and isoflavone snacks for hypertensive patients. The research design used an experimental study design using a Complete Experimental Design (RAL) consisting of one factor in the form of 3 types of soybean and banana balance, namely 25%:75%, 50%:50%, 75%:25%. The research method used an organoleptic test with a hedonic test of 7 numerical scale on 30 moderately trained panelists. The results of U-Bansoy Pudding organoleptic test on the color and texture that the panelists liked the most was a 50%:50% balance. U-Bansoy pudding organoleptic test results on the aroma that the panelists most liked were the balance of 25%:75% and 50%:50%, while the results of the organoleptic test of U-Bansoy pudding on the taste and overall (overall) balance of 25%:75% were the most preferred by the panelists. By consuming one serving of U-Bansoy Pudding with a balance of 25%:75% is enough to contribute as an alternative distraction for hypertensive patients with 185.95 grams of energy, 8.74 grams of protein, 3.64 grams of fat, 34.2 grams of carbohydrates, 533.14 mg of potassium and 30.9 mg of isoflavones. U-Bansoy pudding can be used as an alternative snack for hypertensive patients who need a diet high in potassium and isoflavones.
Safety and Tolerability of Adipose-Derived Mesenchymal Stem Cell (ADR-001) Therapy for IgA Nephropathy
Authors: Tanaka Akihito , Furuhashi Kazuhiro , Fujieda Kumiko , Horinouchi Asuka , Maeda Kayaho , Saito Shoji , Mimura Tetsushi , Saka Yosuke , Naruse Tomohiko , Ishimoto Takuji , Kato Noritoshi , Kosugi Tomoki , Kinoshita Fumie , Kuwatsuka Yachiyo , Nakai Yasuhiro , Maruyama Shoichi 
Published: August 2024

Key Points

IgA nephropathy often requires KRT.Mesenchymal stem cells offer clinical benefits.Adipose-derived mesenchymal stem cells are safe and tolerable.

Background
IgA nephropathy (IgAN) often requires KRT because of its refractoriness and because corticosteroids pose infection risks. However, mesenchymal stem cells offer clinical benefits because of their regenerative and immunomodulatory properties. This prospective clinical trial assessed the safety and tolerability of adipose-derived mesenchymal stem cell (ASC) therapy and evaluated its therapeutic efficacy.

Methods
This phase 1 study included adult patients with refractory IgAN that was difficult to treat with traditional therapies. ASC therapy comprising one intravenous dose of 1×108 cells was administered to three to six patients in Cohort 1. The same intravenous dose was administered twice with a 2-week interval to six patients in Cohort 2. Heparin was administered simultaneously. This study continued for 52 weeks, and the primary end points were safety and tolerability during the 6-week period after treatment administration. Secondary end points included adverse events and efficacy measures such as clinical remission, partial remission, urine protein remission, hematuria remission, time to remission, changes in the urine protein and hematuria levels, and changes in the eGFR.

Results
The three patients in Cohort 1 and six patients in Cohort 2 who received ASC therapy achieved the primary end points. No severe adverse clinical events were observed. Therefore, the safety and tolerability of ASCs were confirmed. Improvements, such as significantly decreased kidney damage markers and urinary protein levels, were observed immediately after ASC administration.

Conclusions
The safety and tolerability of ASCs are acceptable for patients with IgAN.

Clinical Trial registry name and registration number:
This trial was registered with the Japan Registry of Clinical Trials (jRCT2043200002; registration date: April 14, 2020) and ClinicalTrials.gov (NCT04342325; registration date: April 13, 2020).
CONCEPTUAL ASPECTS OF STUDYING OF REGIONAL SOCIO-ECONOMIC SYSTEMS’ RESILIENCE
Authors: Быстров В.В. , Халиуллина Д.Н. 
Published: August 2024

Работа посвящена теоретическим вопросам исследования региональных социально-экономических систем с позиции концепции жизнеспособности (resilience). Авторы предпринимают попытку систематизировать актуальное состояние изучения жизнеспособности сложных систем и критических инфраструктур. Рассматривается многообразие терминов, связанных с понятием «жизнеспособность систем», сделан вывод о наличии дублирования терминов. На основе анализа стадий (фаз, этапов) жизненного цикла предложено описание структуры и каждого из основных этапов жизненного цикла жизнеспособности системы. Приводится классификация видов жизнеспособности, полученная в ходе анализа открытых источников информации (около 150 научных публикаций и отчетной документации по научно-исследовательским проектам), что позволило обосновать отсутствие единого универсального методологического фундамента для изучения жизнеспособности с общесистемной позиции. Рассматриваются методологии изучения жизнеспособности технических (природно-промышленных) и социально-экономических систем, сделан вывод о разнообразии применяемых методологических средств для исследования жизнеспособности сложных систем. Развивая идею, что жизнеспособность социально-экономической системы нужно рассматривать в соответствии с ее масштабом, авторами в ходе анализа систематизированы выявленные определения жизнеспособности региональных социально-экономических систем по их масштабу. Авторами сформулировано определение жизнеспособности региональной социально-экономической системы класса «Бизнес-Сообщество-Власть».
The work is devoted to theoretical issues in the study of regional socio-economic systems in the resilience context. The authors make an attempt to systematize the current state of studying the complex systems and critical infrastructures resilience. The variety of “system resilience” concept terms is considered, and a conclusion is made about the terms duplication presence. Based on the life cycle stages (phases) analysis, a description of the structure and each stage is proposed. A resilience types’ classification is presented, according to the open information sources analysis (about 150 scientific publications and reporting documentation on research projects), which made it possible to justify the lack of a unified universal methodological foundation for studying resilience from a system-wide position. Methodologies for studying the technical (natural-industrial) and socio-economic systems resilience are considered, and a conclusion is drawn about the variety of methodological tools used to study the complex systems resilience. Developing the idea that the socio-economic system resilience should be considered in accordance with its scale; in the course of the analysis, the authors systematized the identified regional socio-economic systems resilience definitions according to their scale. The authors formulated a definition of the “regional Business-Community-Authority socio-economic system resilience”.
ISSUES OF PROFESSIONAL STANDARDS APPLICATION IN UNIVERSITY HR MANAGEMENT
Authors: Антипина И.О. 
Published: August 2024

В статье представлен опыт применения профессиональных стандартов в управлении персоналом государственного российского университета – от этапа внедрения в 2014 - 2018 годах до настоящего времени. Рассматривается проблема поиска механизмов оптимизации работы кадровой службы вуза с большим массивом профессиональных стандартов. На первом этапе эффективным механизмом организации работы стали планы-графики внедрения профессиональных стандартов на период 2016 - 2019 годов. В публикации описана структура и примерное содержание такого документа. Для оптимизации работы на современном этапе автор предлагает вести и актуализировать реестр профессиональных стандартов организации. В статье предложена примерная структура такого реестра. Кроме того, для своевременного отслеживания утверждения новых профстандартов, автор рекомендует вносить в предлагаемый реестр профессиональные стандарты, находящиеся в разработке или в процессе пересмотра, которые планируется внедрить в организации после их издания. В ситуации постоянного обновления профессиональных стандартов необходимо создание в вузе гибкой системы нормативного регулирования процессов управления персоналом. Основой этой системы должна стать современная методология национальной системы квалификации России и стратегия развития организации.
The article presents the experience of professional standards’ applying in HRM at a Russian state university: from the implementation stage in 2014-2018 to the present. The problem of finding mechanisms for optimizing the university’s staff service work with a large array of professional standards is considered. At the first stage, professional standards implementation schedules for the period 2016-2019 became an effective mechanism for organizing work. The publication describes the structure and approximate content of such a document. To optimize work at the present stage, the author proposes to maintain and update the register of professional standards in the organization. The article proposes an approximate structure of such a register. In addition, in order to timely track the approval of new professional standards, the author recommends adding to the proposed register professional standards that are under development or in the revision process, which are planned to be implemented in organizations after their publication. In a situation of professional standards’ constant updating, it is necessary to create a flexible regulation system of HRM processes at the university. This system basis should be the modern methodology of the Russian national qualification system and the organization’s development strategy.
MECHANISM FOR THE STRATEGY DEVELOPMENT AND IMPLEMENTATION OF THE SERVICE SECTOR INNOVATIVE DEVELOPMENT
Authors: Тхор Е.С. , Тхор С.А. , Макарова Е.И. 
Published: August 2024

В статье рассмотрен механизм разработки и реализации стратегии инновационного развития сферы услуг. Представлена стратегия инновационного развития, которая описывается как последовательная смена явлений, состояний, совокупности действий для достижения определенного результата – повышение качества и технологичности услуг. Для организационно-методического обеспечения процесса формирования и реализации стратегии инновационного развития предложен механизм разработки и реализации стратегии инновационного развития предприятий сферы услуг, состоящий из последовательных этапов. Предприятиям сферы услуг целесообразен переход на новую интегрированную систему управления инновационным процессом как самостоятельным объектом управления. В условиях цифровой стратегии развития общества, совершенствования информационного обеспечения выделены несколько подходов к оценке эффективности перспектив инновационного развития сферы услуг. Предложен механизм разработки и реализации стратегии инновационного развития сферы услуг в контексте применения кластерных технологий. Описаны отличительные черты кластерного подхода, характеризующегося возникновением положительных эффектов: эффекта масштаба, эффекта охвата и эффекта синергии. Предложено применение метода экспертных оценок для анализа эффекта синергии. Отмечено, что предприятиям сферы услуг целесообразен переход на новую интегрированную систему управления инновационным процессом как самостоятельным объектом управления.
The article considers the development and implementation mechanism of the innovative development strategy in the service sector. The innovative development strategy is presented, which is described as a sequential change of phenomena, states, and a set of actions to achieve a certain result – improving the services quality and manufacturability. For organizational and methodological support of the innovative development strategy’s formation and implementation process, a mechanism for the innovative development strategy’s development and implementation in the service sector, consisting of successive stages, is proposed. In the digital strategy context for the society development and the information support improvement, several approaches to assessing the prospects effectiveness for service sector innovative development have been identified. A mechanism for the strategy development and implementation for the service sector innovative development in the context of the cluster technologies usage is proposed. The distinctive features of the cluster approach, characterized by the emergence of positive effects: scale effect, scope effect and synergy effect, are described. The use of the expert assessment method to analyze the synergy effect is proposed. It is noted that it is expedient for service sector enterprises to switch to a new integrated management system of the innovation process as an independent management object.
ALGORITHM FOR ASSESSING STUDENTS' RESEARCH COMPETENCIES
Authors: Патутина С.Ю. , Пеша А.В. 
Published: August 2024

Управление научно-исследовательским потенциалом молодежи сегодня самая актуальная задача для нашей страны. Для эффективного управления очень важно разработать типовую систему мониторинга и оценки научно-исследовательской деятельности организаций и предприятий различных сфер деятельности на всех уровнях их существования. Основой проведения исследования послужил системный подход, связанный с применением метода моделирования, что позволило комплексно изучить и воспроизвести строение и свойства и качества алгоритма оценки научно-исследовательских компетенций студентов. На основе проведенного анализа разработан и представлен авторский алгоритм оценки научно-исследовательского потенциала студента и специалиста, раскрытый в трех взаимосвязанных моделях оценки. Полученные результаты лягут в работу проведения эмпирического исследования эффективности формирования научно-исследовательских компетенций студентов вузов при осуществлении ими профессиональной деятельности после окончания университета.
Managing the research potential of young people today is the most urgent task for our country. For effective management, it is very important to develop a standard system for monitoring and evaluating the research activities of organizations and enterprises in various fields of activity at all levels of their existence. The basis of the research was a systematic approach associated with the use of the modeling method, which allowed to comprehensively study and reproduce the structure and properties and qualities of the algorithm for evaluating students' research competencies. Based on the analysis, the author's algorithm for evaluating the research potential of a student and a specialist, disclosed in three interrelated assessment models, is developed and presented. The results obtained will form the basis of an empirical study of the effectiveness of the formation of research competencies of university students in their professional activities after graduation.
Effect of Dexmedetomidine in Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Study
Authors: Zhikharev V. A. , Bushuev A. S. , Arutyunyan R. A. , Porhanov V. A. 
Published: August 2024

Background: One-lung ventilation is used to improve surgical visualization and facilitate thoracoscopic manipulations; however, it induces ventilation/perfusion mismatch, exacerbating the inflammatory response that causes hypoxemia in the perioperative period. Opioid analgesics are the main analgesic drugs used during video-assisted thoracoscopic surgery (VATS), but their use is associated with adverse effects and higher risk of respiratory complications. Corrective measures to eliminate hypoxemia, reduce the inflammatory response, control pain, and minimize opioid-induced adverse effects are crucial in thoracic surgery.Objective: To study the efficacy of dexmedetomidine in reducing lung damage and postoperative complications after VATS.Materials and methods: We examined 100 patients who underwent lobectomy via a thoracoscopic approach. The patients were grouped based on anesthetic management: group 1 (n = 50) with intraoperative dexmedetomidine and group 2 (n = 50) without it. We determined the level of pro-inflammatory cytokines IL-6, IL-8, and TNF and calculated PaO2/FiO2 and A-aDO2. We also assessed the postoperative pain intensity, need for trimeperidin promedol and tramadol, and incidence of postoperative complications.Results: During one-lung ventilation, patients from group 1 had higher PaO2/FiO2 values (P = .025). The A-aDO2 value was higher in group 2 (P = .006). After surgery, we found differences in the content of TNF and IL-8 (P < .001). Twenty-four hours after surgery, we recorded a more significant prevalence of the studied cytokines in group 2 (P < .001). There were no significant differences in the pain dynamics on the first postoperative day (P > .05). Opioid analgesics were less needed in group 1 than in group 2 (P < .001). The incidence of postoperative complications did not differ significantly.Conclusions: Dexmedetomidine in thoracic surgery improves the oxygenation and reduces the percentage of intrapulmonary shunting by inhibiting the release of pro-inflammatory cytokines. In the postoperative period, dexmedetomidine reduces the need for opioid analgesics, but does not affect the pain level or incidence of complications.