bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Late Ptolemaic Order to Distribute One-Choinix Bread Loaves (P.Freib. 77)
Authors: Gerardin François 
Published: July 2024

Abstract
The late Ptolemaic document from the Freiburg papyrus collection published here for the first time is an order to distribute bread loaves. Fully preserved, it is of particular interest for its lexicographical novelties, such as the hitherto unattested adjective χοινικιεῖος. The article further discusses the origin, nature, and use of ὁλοπυρῖται ἄρτοι, “loaves of unground wheat,” and corrects editions of papyri mentioning ἄρτοι χοινικαῖοι (CPR I 31, P.Duke inv. 85 and P.Oxy. XXIV 2424 descr.).
Il problema di calcolo di interessi di SB XXIV 16038 A: errori di tradizione?
Authors: Savio Martina 
Published: July 2024

Abstract
The ‘mistakes’ in the arithmetical problem of SB XXIV 16038 A turn out to be most likely explained not as calculation mistakes but as errors occurred in a copying process, both considered in themselves and in the light of the transmission tendencies that can be detected in the papyrological tradition of this kind of mathematical texts. These errors appear to be strictly analogous or maybe in some way connected with the similar inconsistencies that affect the text of the closest parallel, namely, two loan problems of P.Mich. III 145 fr. 3 col. vii.1-4 (probl. 1) and 5-7 (probl. 2).
“You Are the Pillar of Light That Supports the Whole World”: A Letter to Pesynthios of Koptos, Late Antique Concepts of a “Pillar of Light” and New Evidence for the Christian Redaction of the History of the Captivity in Babylon
Authors: Krueger Frederic 
Published: July 2024

Abstract
This article provides the join and re-edition of two previously edited Coptic ostraca which can now be identified as another letter to the famous 7th-century Egyptian bishop Pesynthios of Koptos, found like the rest of his correspondence at the Monastery of Epiphanius in Western Thebes. It is outstanding in its use of hagiographical language even within an archive notorious for such tendencies. In particular, the article explores the enigmatic title and theological concept “Pillar of Light.”
Baculovirus-mediated endostatin and angiostatin activation of autophagy through the AMPK/AKT/mTOR pathway inhibits angiogenesis in hepatocellular carcinoma
Authors: Wei Tingting , Cheng Jiajie , Ji Yonggan , Cao Xue , Ding Shuqin , Liu Quanxia , Wang Zhisheng 
Published: July 2024

Abstract
Hepatocellular carcinoma (HCC) is a highly vascularized carcinoma, and targeting its neovascularization represents an effective therapeutic approach. Our previous study demonstrated that the baculovirus-mediated endostatin and angiostatin fusion protein (BDS-hEA) effectively inhibits the angiogenesis of vascular endothelial cells and the growth of HCC tumors. However, the mechanism underlying its anti-angiogenic effect remains unclear. Increasing evidence suggests that autophagy has a significant impact on the function of vascular endothelial cells and response to cancer therapy. Hence, the objective of this research was to investigate the correlation between BDS-hEA-induced angiogenesis inhibition and autophagy, along with potential regulatory mechanisms. Our results demonstrated that BDS-hEA induced autophagy in EA.hy926 cells, as evidenced by the increasing number of autophagosomes and reactive oxygen species, accompanied by an upregulation of Beclin-1, LC3-II/LC3-I, and p62 protein expression. Suppression of autophagy using 3-methyladenine attenuated the functions of BDS-hEA-induced EA.hy926 cells, including the viability, proliferation, invasion, migration, and angiogenesis. Moreover, BDS-hEA induced autophagy by downregulating the expression of CD31, VEGF, and VEGFR2, as well as phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR), while concurrently upregulating phosphorylated AMP-activated protein kinase (p-AMPK). The in vivo results further indicated that inhibition of autophagy by chloroquine significantly impeded the ability of BDS-hEA to suppress HCC tumor growth in mice. Mechanistically, BDS-hEA prominently facilitated autophagic apoptosis in tumor tissues and decreased the levels of ki67, CD31, VEGF, MMP-9, p-AKT, and p-mTOR while simultaneously enhancing the p-AMPK expression. In conclusion, our findings suggest that BDS-hEA induces autophagy as a cytotoxic response by modulating the AMPK/AKT/mTOR signaling pathway, thereby exerting anti-angiogenic effects against HCC.
Optimization of ECR assisted pre-ionization in GLAST-III via Multiphysics simulation
Authors: Shakir Sehrish , Khan Riaz , Ali Ahmad , Khan Shahab Uddin , Rehman Zia Ur , Qayyum Abdul , Abdullah Muhammad , Zahid Shahzaib , Kamran Muhammad 
Published: July 2024

Abstract
Electron cyclotron resonance (ECR) is a common pre-ionization technique to assist ohmic startup in tokamaks. In this research, ECR assisted pre-ionization in GLAST-III tokamak is comprehensively investigated via Multiphysics 3D COMSOL simulations. Optimal conditions for ECR microwave absorption at fundamental mode are determined to achieve reliable plasma startup. The effect of filled gas pressure on the ECR plasma parameters such as plasma density and plasma temperature is thoroughly investigated in the range of 0.08–1 Pa. The results reveal that the ECR absorption of the incident microwaves is significantly enhanced at low enough filled argon pressure. The behavior of absorbed microwave power is significantly changed for different filled gas pressures. In case of high gas pressure, the microwave power is deposited locally in front of the waveguide, whereas in case of low pressure (0.08 Pa), the microwave power is uniformly deposited along the resonance layer. Moreover, the experimental investigation extends to nearly identical operating conditions, confirming the ECR absorption. The experimental data aligns with the simulation results, collectively affirming the efficacy of optimized pre-ionization in the low gas pressure scenario (0.08 Pa) within the GLAST-III tokamak.
Methodology for analyzing dose consequence using atmospheric dispersion code A2CDOSE
Authors: Chiang Yu , Lu Chung-hsin , Teng Jen-hsin , Wang Jong-Rong , Chen Shao-Shuan , Chen Shao-Wen 
Published: July 2024

Abstract
The experience of Fukushima brings out the importance of the emergency response plan during or after a severe nuclear power plant (NPP) accident. To deal with the accident emergency response situation, the National Atomic Research Institute (NARI) in Taiwan developed an emergent radiological dose evaluation system with the Central Weather Administration (CWA) called “A2CDOSE”. A2CDOSE can evaluate the eight-day projected dose after a nuclear accident and provide the predicted dose consequences for decision-making. Nevertheless, a source term generation method was still needed during the accident. This study chose MELCOR as the comparison target for the source term simulation issue with RASCAL. A MELCOR calculation of Maanshan NPP was built and a 5 % containment leakage was set for both MELCOR and RASCAL source term calculations. It seems the calculations of noble gases were consistent between MELCOR and RASCAL. However, the Cs-137 and I-131 calculated by MELCOR were twice compared to the RASCAL results, which may have a chance to cause different calculations of public protective actions during an accident. After the source term analysis, several atmospheric dispersion cases were simulated by A2CDOSE and RASCAL for further comparison.
Integrating bulk-RNA and single-cell analysis reveals heterogeneous expression of cuproptosis-related sorafenib-resistant genes in hepatocellular carcinoma
Authors: Yu Ziqian , Song Linnan , Wang Yuhao , Chen Xinhui , Chen Peng , Zhong Shihong , Li Yongyin , Tang Libo 
Published: July 2024

Abstract

Objectives
Cuproptosis represents the copper-dependent novel cell death pattern. However, the effects of cuproptosis-related sorafenib-resistant genes on prognosis, treatment response, and sorafenib resistance in hepatocellular carcinoma (HCC) patients are still unclear. The present work aims to develop a cuproptosis-related signature for predicting HCC prognosis.

Methods
Cuproptosis-related sorafenib-resistant differentially expressed genes (CRSRDEGs) were identified by correlation analysis between cuproptosis genes and sorafenib-resistant genes using electronic databases TCGA and GEO. Besides, the cuproptosis-related sorafenib-resistant risk score model (CRSRRSM) was established through LASSO and univariate Cox regression analyses. Later, this model was adopted for analyzing HCC patient prognosis. Certain potential drugs and treatment sensitivity were also analyzed in HCC patients receiving sorafenib or transarterial chemoembolization (TACE) treatment.

Results
The CRSRRSM achieved excellent efficiency in predicting the prognosis and sorafenib or TACE treatment response of HCC patients. As revealed by somatic mutational analyses, CRSRRSM was associated with tumor mutational burden (TMB), especially for TP53, CSMD3, and OBSCN mutations. According to functional enrichment analysis, CRSRRSM was closely correlated with tumor-related pathways, cuproptosis-related tricarboxylic acid (TCA) cycle, and drug resistance. Notably, potential drugs such as sepantronium bromide, AZD8055, and RO-3306, the promising alternatives for treating HCC patients with sorafenib resistance, were also proposed based on CRSRRSM. Furthermore, single-cell transcriptomic analysis revealed that high-risk malignant cells demonstrated an increased capacity of proliferation and immune evasion.

Conclusions
A model, designated CRSRRSM, was constructed that can effectively predict the prognosis, sorafenib treatment response, and potential drugs for sorafenib resistance in HCC patients. This model provides potential implications for clinical management of HCC patients with sorafenib resistance.
Thermal analysis of extended surfaces using deep neural networks
Authors: Oloniiju Shina Daniel , Tijani Yusuf Olatunji , Otegbeye Olumuyiwa 
Published: July 2024

Abstract
The complexity of thermal analysis in practical systems has emerged as a subject of interest in various fields of science and engineering. Extended surfaces, commonly called fins, are crucial cooling and heating mechanisms in many applications, such as refrigerators and power plants. In this study, by using a deterministic approach, we discuss the thermal analysis of conduction, convection, and radiation in the presence of a magnetic force within an extended surface. The present study develops a deep neural network to analyze the mathematical model and to estimate the contributions of each dimensionless model parameter to the thermal dynamics of fins. The deep neural network used in this study makes use of a feedforward architecture in which the weights and biases are updated through backward propagation. The accuracy of the neural network model is validated using results obtained from a spectral-based linearization method. The efficiency rate of the extended surfaces is computed using the neural network and spectral methods. The results obtained demonstrate the accuracy of the neural network-based technique. The findings of this study in relation to the novel mathematical model reveal that utilizing materials with variable thermal conductivity enhances the efficiency rate of the extended surface.
Acute Effects of High-Intensity Resistance Exercise on Recognition of Relational Memory, Lactate, and Serum and Plasma Brain-Derived Neurotrophic Factor
Authors: Baumgartner Nicholas W. , Belbis Michael D. , Kargl Christopher , Holmes Michael J. , Gavin Timothy P. , Hirai Daniel M. , Kao Shih-Chun 
Published: July 2024

Abstract
Baumgartner, NW, Belbis, MD, Kargl, C, Holmes, MJ, Gavin, TP, Hirai, DM, and Kao, S-C. Acute effects of high-intensity resistance exercise on recognition of relational memory, lactate, and serum and plasma brain-derived neurotrophic factor. J Strength Cond Res XX(X): 000–000, 2024—Acute aerobic exercise improves memory, but this phenomenon is understudied in response to resistance exercise (RE) despite evidence that RE-induced increases in lactate and brain-derived neurotrophic factor (BDNF) play mechanistic roles in memory performance. To determine the acute effect of RE on lactate, BDNF, and their associations with object and relational memory, blood lactate, and serum and plasma BDNF were taken from 36 adults (average age 23.64 ± 3.89 years; 18 woman) before and immediately after 42 minutes of high-intensity RE and a rest condition on counterbalanced days. Subjects then immediately studied a series of paired objects and completed object and relational recognition tasks. Results revealed a condition by trial interaction, previously studied objects were remembered less accurately following RE (d = 0.66) but recognition occurred faster (d = 0.28), indicating a speed-accuracy tradeoff following RE. There was no effect of either intervention on relational recognition performance. Lactate (d = 3.68) and serum BDNF (d = 0.74) increased following RE, whereas there was no time-related change in lactate and serum BDNF following rest. However, changes in lactate and BDNF did not predict any measures of object (rs < 0.25, ps > 0.16) or relation recognition (rs < 0.28, ps > 0.13). Collectively, these findings suggest that acute high-intensity RE selectively improves the processing speed of recognizing objects at the cost of less accurate recognition of previously studied objects. Furthermore, changes in object and relational memory performance are unlikely driven by acute increases in lactate or BDNF following high-intensity RE.
The Effect of Traditional Strength Training on Sprint and Jump Performance in 12- to 15-Year-Old Elite Soccer Players: A 12-Month Controlled Trial
Authors: Skratek Josua , Kadlubowski Björn , Keiner Michael 
Published: July 2024

Abstract
Skratek, J, Kadlubowski, B, and Keiner, M. The effect of traditional strength training on sprint and jump performance in 12- to 15-year-old elite soccer players: a 12-month controlled trial. J Strength Cond Res XX(X): 000–000, 2024—The aim of the study was to evaluate the effect of traditional strength training on maximum strength (1 repetition maximum in front squat [FS] and back squat [BS]), jump (squat and countermovement jump), and linear sprint (LS) performance (5, 10, and 30 m) in elite young soccer players. A 12-month longitudinal design was chosen, and 48 elite male youth soccer players (age: 12–15 years) were included. The subjects were divided in 2 groups (a strength training group [STG] and a control group [CG]). The intervention group trained for 1 year over a competitive soccer season with additional sessions to their regular soccer practice (4 sessions per week), while the CG did not complete any additional sessions to the regular soccer training (4 sessions per week). The additional strength training (2 sessions per week [each approximately 30 minutes]) consisted of either parallel FS or BS. The squat variants switched in each session. Data were analyzed using a 2 × 3 (group × time) repeated-measures analysis of variance. The main findings of this study were that the STG resulted in significant pretest and post-test improvements in maximum strength (d = 3.75–5.58), jump (d = 0.84–1.14), and LS performance (d = −0.25 to 0.44), while for the CG, smaller increases or performance decreases were measured (maximum strength: d = 1.64–2.7; jump: d = 0.12–0.31; sprint: d = 0.00–025). A significant interaction effect in all variables indicated significant (p < 0.05) stronger performance improvements compared with the CG. Traditional strength training in elite youth soccer players is recommended to increase strength and speed–strength (jump and sprint performance) and should be considered in long-term athletic development programs.
The effects of the activation of TLR2/TLR1 on in vitro angiogenesis in an immortalized ovine luteal endothelial cell line
Authors: Yaman Gram Duygu , Abay Murat , Liman Narin , Tekin Muhittin , Kowalewski Mariusz P , Gram Aykut 
Published: July 2024

In brief
Activation of TLR2/TLR1 alters in vitro formation of capillary-like structures and induces inflammatory processes in ovine luteal endothelial (OLENDO) cells.

Abstract
Postpartum bacterial infections of the uterus affect uterine physiology and ovarian activity, causing fertility problems. The outer membrane component of Gram-negative bacteria, lipopolysaccharide, is involved in the initiation of the local inflammatory processes, and other bacterial toxins, particularly lipopeptides, have also been shown to be potent cytokine inducers, acting via Toll-like receptor-2 (TLR2). However, the possible adverse effects of TLR2 on ovarian and luteal activities have not yet been investigated in depth. The strong expression of TLR2 in the blood vessels of the corpus luteum led us to hypothesize that TLR2 activation might participate in the disruption of luteal vascular functionality. Therefore, we analyzed the effects of Pam3CSK4 (Pam3CysSerLys4), a synthetic triacylated lipopeptide and TLR2/TLR1 ligand, on the functionality of gap junctional intercellular communication (GJIC), endothelial cell invasion, and in vitro capillary-like network formation in an immortalized ovine luteal endothelial (OLENDO) cell line. Pam3CSK4 treatment of OLENDO cells disrupted in vitro tube formation but had no effect on GJIC or migration of OLENDO cells. Furthermore, Pam3CSK4 induced the expression of NFKB, IL6, and IL8 in OLENDO cells. Additionally, the basal availability of TLRs (TLR1–10) and TLR co-receptors (MYD88, LY96/MD2, and CD14) in OLENDO cells was confirmed by conventional PCR. Finally, the activation of TLR2/TLR1 appears to alter in vitro formation of capillary-like structures and induce inflammatory processes in OLENDO cells.
Treinta años de arqueología de género
Authors: Rodríguez González Celtia 
Published: July 2024

El estudio de la arqueología de género no es una empresa nueva. Sus avances en el mundo de la investigación han dotado a la ciencia de nuevas formas de leer el pasado y entender el presente tanto a nivel internacional como nacional. Todo este avance ha tardado en implantarse dentro del estado español, pero sobre todo en el noroeste de la Península Ibérica. Esto se debe, en buena parte, a la vinculación que existe de muchas historiadoras a la fuente escrita, suponiendo, en muchos casos, un freno en el estudio y el análisis de la materialidad arqueológica. Además, da lugar a la falta de una crítica teórica en este ámbito. Partimos de una puesta al día de los trabajos desarrollados sobre arqueología de género tanto a nivel internacional como nacional, para centrarse a continuación en la presentación de un estudio sobre la historiografía de género en la arqueología, desde sus orígenes, en el Noroeste, concretamente en Galicia. En esta región, la arqueología de género es todavía un enfoque con aplicación limitada, evidenciando en este trabajo la necesidad de analizar a las sociedades del pasado desde la materialidad y con perspectiva de género, en el noroeste de la península ibérica, así como en el contexto gallego.
Participation of apomictic cereals in composition of steppe and ecotone phytocenoses in the north of the Lower Volga region
Authors: Юдакова О.И. , Кайбелева Э.И. , Нющенко Е.А. , Лысенко Т.М. , Воронин М.Ю. 
Published: July 2024

Проведен геоботанический анализ 160 степных и экотонных растительных сообществ с участием злаков на севере Нижнего Поволжья (в пределах Саратовской области). Во флоре региона и в изученных фитоценозах видовое разнообразие апомиктичных злаков значительно уступает разнообразию их амфимиктичных сородичей. Так, во флоре Саратовской области злаки представлены 133 видами, из которых только у 24 видов зарегистрированы эмбриологические признаки факультативного апомиксиса. В изученных фитоценозах обнаружено 34 амфимиктичных и 17 апомиктичных видов злаков. При этом доминанты в них в равной степени представлены как амфимиктичными (14 видов), так и апомиктичными злаками (9 видов). Амфимикты доминируют в 64 фитоценозах, апомикты ‒ в 48. Фитоценозы с доминированием злаков сходны по видовому богатству и выравненности. Количество растительных сообществ, в которых апомиктичные злаки являются содоминантами, достоверно превышает количество растительных сообществ с содоминированием амфимиктов (46 и 22 соответственно). Полученные данные свидетельствуют об успешной конкуренции апомиктичных злаков с амфимиктами и их весомом вкладе в сложение степных и экотонных фитоценозов севера Нижнего Поволжья.
A geobotanical analysis of 160 steppe and ecotone plant communities with the participation of cereals in the north of the Lower Volga region (within the Saratov region) was carried out. The species diversity of apomictic cereals is significantly inferior to the diversity of their amphymictic relatives in the flora of the region and in the studied phytocenoses (24 apomictic and 109 amphymictic species in the flora; 17 and 34 species in the phytocenoses, respectively). At the same time, the dominants of the studied communities are equally represented by both amphymictic (14 species) and apomictic cereals (9 species). It was established that cereals with amphymictic mode of reproduction dominate in 64 phytocenoses, apomictic cereals dominate in 48 ones. The number of phytocenoses in which apomicts are codominants significantly exceeds the number of plant communities with amphymicts codominance (46 and 22, respectively). The studied plant communities are similar in species richness and evenness. The obtained data indicate successful competition between apomictic cereals and amphymicts and their significant contribution to the composition of steppe and ecotone phytocenoses in the northern Lower Volga region.