bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of sleep on motor skill acquisition in children: a systematic review
Authors: Filho José Messias Vieira Marques , de Oliveira Antônio Anderson Ramos , de Bruin Veralice Meireles Sales , Viana Ricardo Borges , de Bruin Pedro Felipe Carvalhedo 
Published: August 2024

SummaryEffects of sleep on procedural (implicit) memory consolidation in children remain controversial. The aim of this systematic review was to synthesise the evidence on the influence of sleep on motor skills acquisition in children. Four electronic databases were searched: PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Excerpta Medica Database (Embase), and Biblioteca Virtual em Saúde (BVS). Original studies, published until October 17, 2023, on motor skill acquisition in children aged ≤12 years, in which the intervention group slept after motor skill training, while the control group remained awake, were considered for inclusion. Risk of bias was evaluated using the Cochrane's Risk of Bias 2 tool. The review protocol was pre‐registered at the International Prospective Register of Systematic Reviews (PROSPERO protocol number: CRD42022363868) and all reported items followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Of the 7241 articles initially retrieved, nine met the primary criteria and were included in this review. Of these, six studies reported that daytime or night‐time sleep intervention improved motor skill acquisition, as compared to wakefulness. All studies presented a high risk of bias. In conclusion, the evidence summarised suggests that sleep may enhance motor skills acquisition and could be important for motor development in childhood. However, due to the high risk of bias in the included studies, future randomised controlled trials with high methodological quality are necessary to better clarify this topic.
Time to resolution of airway inflammation caused by bronchoalveolar lavage in healthy horses
Authors: Woodrow Jane S. , Hopster Klaus , Palmisano Megan , Payette Flavie , Kulp Jeaneen , Stefanovski Darko , Nolen‐Walston Rose 
Published: August 2024

AbstractBackgroundBronchoalveolar lavage (BAL) is a common procedure for evaluation of the equine lower airways. Time to resolution of post‐BAL inflammation has not been clearly defined.HypothesisResidual inflammation, evident by changes in immune cell populations and inflammatory cytokines, will resolve by 72 hours after BAL.AnimalsSix adult, healthy, institution‐owned horses.MethodsRandomized, complete cross‐over design. Each horse underwent 3 paired BALs, including a baseline and then 48, 72, and 96 hours later, with a 7‐day washout between paired BALs. Each sample underwent cytological evaluation and cytokine concentrations were determined by a commercially available multiplex bead immunoassay. Statistical analysis was performed by multilevel mixed‐effects Poisson regression analysis. Data are reported as marginal means and 95% confidence interval (CI).ResultsNeutrophil, eosinophil and mast cell percentages were not significantly different at any time points. Macrophage percentages were higher at 72 hours (45.0 [95% CI, 41.6‐48.4]%) and 96 hours (45.3 [95% CI, 42.9‐47.7]%) vs baseline (37.4 [95% CI, 33.5‐41.4]%; P < .001 and P = .01, respectively), and at 72 hours and 96 hours vs 48 hours (31.9 [95% CI, 28.1‐35.6]%; P < .001). Neutrophil percentage was not significantly increased at 48 hours (P = .11). Interleukin (IL)‐6 concentration was increased at 72 hours (5.22 [95% CI, 3.44‐6.99] pg/mL) vs 48 hours (4.38 [95% CI, 2.99‐5.78] pg/mL; P < .001).Conclusions and Clinical ImportanceSignificant lung inflammation was not detected at 72 and 96 hours, suggesting that repeating BAL at 72 hours or more can be done without concern of residual inflammation.
Urothelial carcinoma associated with a long‐term indwelling cystostomy component of a subcutaneous ureteral bypass device in a domestic shorthair cat
Authors: Lackeyram‐Owen Samantha , Gibson Erin , Reetz Jennifer , Chan Taylor , Assenmacher Charles‐Antoine , Clarke Dana L. 
Published: August 2024

AbstractUrothelial carcinoma (UC) occurs uncommonly in cats and no association has previously been observed with long‐term indwelling urinary implants. An 18‐year‐old male castrated domestic shorthair cat initially was presented for hematuria, leading to the diagnosis of a right‐sided ureterolithiasis and severe pyelectasia on ultrasound examination, prompting right‐sided subcutaneous ureteral bypass (SUB) device placement. The cat subsequently had intermittent hematuria and dysuria, without ultrasonographic abnormality of the bladder or positive urine culture. Thirteen months later the patient developed refractory lower urinary tract signs, azotemia, a proliferative mass in the region of the cystostomy tube component of the SUB device and evidence of left ureteral obstruction. Cystostomy tube revision and left‐sided SUB device placement were performed, as well as a partial cystectomy for removal of the mass. Upon histopathology, the mass was diagnosed as a UC. To our knowledge, UC associated with a long‐term indwelling cystostomy catheter component of a SUB device has not been reported in veterinary medicine.
Grass layer limits tree seedling survival but not tree seedling growth in African and South American savannas
Authors: Mochi Lucía S. , Morrison Thomas A. , Stevens Nicola , Mazía Noemí , Anderson T. Michael , Holdo Ricardo M. 
Published: August 2024

AbstractQuestionsHow does the grass layer affect seedlings across large environmental gradients in savannas?LocationSavanna sites in Argentina, Tanzania, and South Africa.MethodsWe carried out a joint analysis of three grass removal experiments in which seedlings of various Fabaceae species were transplanted into plots with native grass and companion plots where grass had been removed. First, we estimated the effect of grasses on tree seedling mortality and seedling growth rate at each site. Then, we used the resulting coefficient estimates from site‐level models to examine the impact of two climate (monthly precipitation and aridity index) and two soil (soil organic carbon content and clay content) variables on the direction and magnitude of the grass effects.ResultsGrasses increased the risk of mortality, but there was no evidence for a global effect of grasses on tree seedling rate of height growth. The best model fit indicated a high mortality risk of tree seedlings in response to grasses at intermediate aridity index values. No other climate or soil variable influenced tree seedling survival or growth (monthly precipitation, soil organic carbon content and clay content).ConclusionsOur results support the notion that the grass layer consistently creates a bottleneck to tree seedling establishment in African and South American savannas beyond climate and soil conditions, mainly by affecting tree seedling survival. The negative effect of grasses on seedling survival was lower in dry conditions compared to intermediate aridity levels. These results suggest that grass–seedling interaction is less intense in drier conditions, possibly due to reduced total grass biomass, which leads to decreased site evapotranspiration and improved soil water retention capacity.
Estimating link flow through link speed with sparse flow data sampling
Authors: Qiu Jiandong , Fu Sicheng , Ou Jushang , Tang Kai , Qu Xinming , Liang Shixiao , Wang Xin , Ran Bin 
Published: August 2024

AbstractIn modern transportation systems, network‐wide traffic flow estimation is crucial for informed decision making, strategic infrastructure planning, and effective traffic management. While the limited availability of observed road‐segment traffic flow data presents a significant challenge, the emerging collection of Global Navigation Satellite System (GNSS) speed data across the entire network provides an alternative method for estimating the missing traffic flow information. To this end, this paper introduces a novel approach to estimating network‐wide road‐segment traffic flow. This approach takes advantage of the abundantly available GNSS speed data, coupled with only sparsely observed traffic flow samples. By integrating the principles of dynamic traffic assignment models with sparse recovery techniques, we formulate the problem of traffic flow estimation as a Least Absolute Shrinkage and Selection Operator (LASSO) optimization task. The efficacy and practical applicability of our proposed method are validated through evaluations using both hypothetical and real‐world case studies. The experimental findings exhibit a close alignment between the estimated and ground‐truth link flows across different time periods. Additionally, the method consistently produces low mean estimation errors for the majority of road segments, underlining the potential for our approach in effectively managing traffic flow estimation for large‐scale road networks, particularly in situations characterized by data scarcity.
Contraceptive effect of a gonadotropin‐releasing hormone vaccine on captive male brown bears (Ursus arctos)
Authors: Matsumoto Naoya , Tomiyasu Jumpei , Hagino Kyogo , Matsui Motozumi , Yanagawa Yojiro 
Published: August 2024

AbstractFertility control has traditionally been applied in zoos to control captive populations, and reversible contraception is important. However, contraceptive methods for male bears have not been reported. We aimed to establish a reversible contraceptive for male brown bears by investigating the effects of a gonadotropin‐releasing hormone (GnRH) vaccine (Improvac®) that was developed for the immune castration of pigs. We vaccinated six bears with two sequential doses of 400 (n = 2) or 600 μg Improvac® (n = 4) with a 1‐month interval during the pre‐breeding season (February to April). We compared the reproductive parameters (testosterone levels and semen parameters) of the six vaccinated and four non‐vaccinated (control) bears once during the breeding season (May or June). To investigate whether the reproductive performance could be restored in the following year of contraception, we also compared the reproductive parameters once during the breeding season in two bears between the year with GnRH vaccination and the following year without vaccination. Vaccination treatments suppressed reproductive parameters in 5 bears, although vaccination with 400 μg of Improvac® was not effective in one bear. Testosterone levels and the rate of progressive sperm motility were significantly lower, and total sperm count and testis size tended to be lower in vaccinated bears, compared with the controls. Blood biochemical findings and direct observations after Improvac® vaccination did not reveal side effects. Moreover, testosterone levels and spermatogenic scores of two bears were restored in the following year. We confirmed that the Improvac® vaccine elicited a reversible contraceptive effect in male brown bears.
Agency independence and credibility in primary bond markets
Authors: Sadeh Tal , Rubinson Eyal 
Published: August 2024

AbstractVast literature studies Independent Regulatory Agencies (IRAs). We contribute by studying the benefits of independence when the agent's work is relational and by studying developing and developed democracies worldwide and over many years. We do this by studying national Debt Management Offices (DMOs)—the state agencies that plan, issue, and manage national debt. DMOs define the benchmark assets on which capital markets and monetary policy depend—industry standards—and their decisions have allocative implications. We argue that formal independence of DMOs from political decision‐makers is a costly signal to large financial institutions on the government's potential to service and repay its debts. We introduce a new country‐year dataset of DMO legislation for 75 developing and developed democratic countries in the period 1950–2013. We find that DMO independence is likelier following debt defaults, war, high inflation, and high debts, and that DMO independence increases sovereign debt credibility.
A comparison of the safety and efficacy of tapinarof and roflumilast topical therapies in the management of mild‐to‐moderate plaque psoriasis
Authors: Ghani Hira , Podwojniak Alicia , Tan Isabella J. , Parikh Aarushi K. , Sanabria Bianca , Rao Babar 
Published: August 2024

AbstractIntroductionPsoriasis is an immune‐mediated inflammatory skin disease. First‐line topical treatments include steroids, calcineurin inhibitors, vitamin D analogs, and anthralin. Recently, novel topical therapeutics like tapinarof and roflumilast have emerged with unique anti‐inflammatory mechanisms and promising efficacy profiles.Materials and methodsThis review utilized PubMed, SCOPUS, and Web of Science databases to identify recent studies on tapinarof and roflumilast. Criteria focused on efficacy, safety profiles, and therapeutic roles in psoriasis treatment.ResultsFour primary literature articles were identified for tapinarof and five for roflumilast. Both drugs demonstrated strong efficacy with minimal adverse events in treating mild‐to‐moderate plaque psoriasis. Tapinarof showed more frequent but mild adverse effects, while roflumilast had less frequent but more severe side effects.DiscussionTapinarof and roflumilast offer once‐daily dosing and successful treatment in restricted areas, potentially enhancing patient adherence. Cost remains a limiting factor, necessitating future comparative studies to evaluate the efficacy, safety, and cost‐effectiveness between the two drugs.ConclusionTapinarof and roflumilast present promising topical treatments for psoriasis, showing efficacy and manageable safety profiles. Further research is crucial to fully elucidate their comparative benefits and drawbacks in clinical practice.
Alternative splicing of CsbHLH133 regulates geraniol biosynthesis in tea plants
Authors: Cheng Long , Tu Gefei , Ma Huicong , Zhang Keyi , Wang Xinyu , Zhou Haozhe , Gao Jingwen , Zhou Jie , Yu Youben , Xu Qingshan 
Published: August 2024

SUMMARYGeraniol is one of the most abundant aromatic compounds in fresh tea leaves and contributes to the pleasant odor of tea products. Additionally, it functions as an airborne signal that interacts with other members of the ecosystem. To date, the regulation of the geraniol biosynthesis in tea plants remains to be investigated. In this study, a correlation test of the content of geraniol and its glycosides with gene expression data revealed that nudix hydrolase, CsNudix26, and its transcription factor, CsbHLH133 are involved in geraniol biosynthesis. In vitro enzyme assays and metabolic analyses of genetically modified tea plants confirmed that CsNudix26 is responsible for the formation of geraniol. Yeast one‐hybrid, dual‐luciferase reporter, and EMSA assays were used to verify the binding of CsbHLH133 to the CsNudix26 promoter. Overexpression of CsbHLH133 in tea leaves enhanced CsNudix26 expression and geraniol accumulation, whereas CsbHLH133 silencing reduced CsNudix26 transcript levels and geraniol content. Interestingly, CsbHLH133‐AS, produced by alternative splicing, was discovered and proved to be the primary transcript expressed in response to various environmental stresses. Furthermore, geraniol release was found to be affected by various factors that alter the expression patterns of CsbHLH133 and CsbHLH133‐AS. Our findings indicate that distinct transcript splicing patterns of CsbHLH133 regulate geraniol biosynthesis in tea plants in response to different regulatory factors.
High‐intensity resistance training and collagen supplementation improve patellar tendon adaptations in professional female soccer athletes
Authors: Lee Joonsung , Robshaw David C. , Erskine Robert M. 
Published: August 2024

AbstractWe investigated whether 10 weeks of pre‐season soccer training (including high‐intensity resistance exercise) with hydrolysed collagen (COL) supplementation would confer greater changes in patellar tendon (PT) mechanical and material properties compared with placebo (PLA) in professional female soccer athletes. Eleven athletes from the first team squad of a Football Association Women's Championship soccer club volunteered to participate in this study (age, 25.7 ± 4.2 years; height, 1.68 ± 0.04 m; mass, 64.0 ± 4.6 kg). Participants were pair‐matched for baseline knee extensor maximum isometric voluntary contraction torque, age, height and mass and were randomly assigned to the COL group (n = 6) or PLA group (n = 5). Participants were given 30 g COL or energy‐matched (36.5 g maltodextrin and 8.4 g fructose) PLA, plus 500 mg vitamin C before each training session, which consisted of high‐intensity lower‐limb resistance exercise, plyometric or pitch‐based exercise 3 days/week for 10 weeks during the pre‐season period. We assessed knee extensor maximum isometric voluntary contraction torque and PT properties using isokinetic dynamometry and ultrasonography before and after the intervention. The PT stiffness [COL, +15.4% ± 3.1% (d = 0.81) vs. PLA, +4.6% ± 3.0% (d = 0.32), P = 0.002] and Young's modulus [COL, +14.2% ± 4.0% (d = 0.65) vs. PLA, +3.4% ± 2.8% (d = 0.15), P = 0.004] increased more in COL than in PLA. There was a main effect of training on PT cross‐sectional area (P = 0.027), but no interaction effect (P = 0.934). To conclude, 10 weeks of pre‐season soccer training (incorporating high‐intensity resistance exercise) with 30 g COL increased PT stiffness and Young's modulus more than training alone in professional female soccer athletes. This has positive implications for improving athletic performance and mitigating injury risk.
A Buffer-Based Steel Production Scheduling Under Uncertain Environment
Authors: Morita Daisuke , Suwa Haruhiko 
Published: August 2024

Abstract
Scheduling in steel manufacturing is a difficult problem with various complex constraints and uncertainties. This study proposes a steel scheduling decision-making model involving time and resource buffers for raw material blending, casting, and rolling planning processes. The proposed model estimates suitable time and resource buffers allocated to the baseline schedule to absorb the operation delay. The numerical experiments clarify the critical properties of the considered scheduling problem and investigate the proposed approach from a macro perspective.
A Study on Hierarchical Production Planning Framework for Engineer-to-Order Production of Large Products
Authors: Iwamura Koji , Morinaga Eiji , Hirahara Yoshiyuki , Fukuda Masamitsu , Niinuma Ayumu , Oshima Hirotomo , Namioka Yasuo 
Published: August 2024

Abstract
Engineer-to-order (ETO) production is a method in which products are designed and manufactured in response to customer orders. Typical products of ETO production targeted in this study are large products such as power plants, plants, and shipbuilding. These products have long lead times and delivery times, and production plans need to be generated for a year or more in advance.
This study proposes a hierarchical production planning (HPP) framework to generate long-term, medium-term, and short-term production plans using common granularity of production equipment and unit time on production planning method for ETO production of large products. A load planning required for the long-term production plan is formulated as an integer programming problem, and the load plans are generated using a mathematical programming solver and a constraint programming solver.
Forced Chatter Sound in End-Milling Processes for Bamboo Fiber Extraction Using a Machining Center
Authors: Tanaka Kaito , Kitazaki Reo , Nakahara Yutaro , Nakagawa Masao , Hirogaki Toshiki , Aoyama Eiichi , Nobe Hiromichi 
Published: August 2024

Abstract
In this study, we attempted to fabricate a self-adhesive molded product made entirely of bamboo. The raw materials were bamboo tube chips cut using a machining center. The chips can be made parallel to the vascular bundles with adjustable dimensions. However, the vibration inherent in the working material during the cutting process could potentially affect the chip shape. Therefore, we evaluated the effect of workpiece-specific vibration on fiber shape. Additionally, cutting sound, which is considered highly correlated with workpiece vibration suppression, was examined. The results showed that the first- (x-parallel) and second-order (y-parallel) intrinsic vibrations decreased the mean fiber width and increased its standard deviation. Cutting sound was also evaluated. The correlation between cutting sound and vibration acceleration was high when the natural to intermittent cutting frequency ratio was an integer. Under other conditions, cutting sound peaks were observed at integer multiples of the intermittent cutting frequency, and the maximum peak occurred at the frequency closest to the natural frequency. Subsequently, a natural frequency calculation method using the cutting sound was proposed. When this equation was applied to actual cutting sounds, the natural frequency was predicted with high accuracy. The results indicate that the spindle speed could be set to avoid the workpiece natural vibration using the cutting sound.
Estimating Muscle Fiber-Type Composition in Elite Athletes: A Survey on Current Practices and Perceived Merit
Authors: Lievens Eline , Van de Casteele Freek , De Block Fien , Van Vossel Kim , Vandenbogaerde Tom , Sandford Gareth N. , Bellinger Phillip , Minahan Clare , Bourgois Jan G. , Stellingwerff Trent , Mujika Iñigo , Derave Wim 
Published: August 2024

Purpose: To gather information on practices and perceptions of high-performance experts regarding their athletes’ muscle fiber-type composition (MFTC) and its estimation. Methods: A questionnaire on the noninvasive versus invasive estimation of MFTC was completed by 446 experts including coaches and sport-science/sports-medicine staff. Moreover, the perceived importance of MFTC for training and performance optimization was assessed. Differences between sport types (individual and team sports) were analyzed using chi-square tests. Results: Forty percent of the experts implemented MFTC assessment in pursuit of performance optimization, while 50% did not know their athletes’ MFTC but expressed a desire to implement it if they would be able to assess MFTC. Ten percent did not perceive value in MFTC assessment. Only 18% of experts believed that their athletes would undergo a muscle biopsy, leading to the adoption of alternative noninvasive techniques. Experts primarily relied on their experience to estimate MFTC (65%), with experts working in individual sports using their experience more frequently than those working in team sports (68% vs 51%; P = .009). Jump tests emerged as the second-most commonly employed method for estimating MFTC (56%). When only considering experts who are currently using MFTC, 87% use MFTC to individualize training volume and 84% to individualize training intensity. Conclusions: Experts value MFTC assessment primarily to individualize training but mainly rely on noninvasive methods to estimate MFTC. Some of these methods lack scientific validity, suggesting a continuing need for education and further research in this area.
Efficacy of ensitrelvir for cough due to COVID-19 Omicron variant in medical healthcare workers
Authors: Miyashita Naoyuki , Nakamori Yasushi , Ogata Makoto , Fukuda Naoki , Yamura Akihisa , Ito Tomoki 
Published: August 2024

ABSTRACT

We evaluated the efficacy of ensitrelvir for the treatment of cough due to coronavirus disease 2019 Omicron variant in medical healthcare workers. A total of 633 patients were registered in this study: 206 patients chose ensitrelvir and 427 patients chose symptomatic treatment. Difference in score changes using the Leicester Cough Questionnaire between groups was 3.17 on day 4, 3.24 on day 7, and 2.46 on day 14. The analysis demonstrated a significant difference at all time points.