bluuebunny/crossref_metadata_2025_split huggingface dataset:
Type 1 diabetes mellitus and bulimia nervosa: insulin restriction does not always represent purging of unwanted calories
Authors: Zander Heike , Beneke Johannes , Vagedes Daniel , Müller Astrid , de Zwaan Martina 
Published: May 2014

AbstractIn the current case study we present a patient with type 1 diabetes mellitus and bulimia nervosa who reported intentionally restricting her insulin intake in order to avoid hypoglycaemic episodes. However, she was not concerned about the occurrence of the typical symptoms of hypoglycaemia such as shaking, sweating, drowsiness, nausea, poor motor coordination, mental confusion or unconsciousness. Her fear of hypoglycaemia was solely based on her perception that hypoglycaemia would inevitably lead to binge eating.With the help of regular food intake, optimised insulin treatment and psychological help, the patient succeeded in reducing the number of binge eating episodes and in achieving a better control of her bulimic symptoms as well as of her diabetes mellitus.
Lipoatrophy: re‐emerging with analogue insulins. Is there a link with CSII?
Authors: Simeonovic Marcelle , Anuar Azriyanti , Edge Julie , Makaya Tafadzwa 
Published: May 2014

AbstractOver the last decade, there has been an increase in reported cases of lipoatrophy as a complication of treatment with analogue insulin preparations. Lipoatrophy causes undesirable cosmetic appearances and may cause variable glycaemic control.We report a case series of four female patients from a tertiary paediatric diabetes unit presenting with lipoatrophy while on treatment with insulin aspart via a continuous subcutaneous insulin infusion (CSII) pump for the management of type 1 diabetes. We did not observe any cases of lipoatrophy in patients receiving multiple daily insulin injections. In examining the effect of lipoatrophy on glycaemic control, we found no detrimental effect of lipoatrophy on the patients’ glycated haemoglobin.Cases of lipoatrophy should be reported to drug manufacturers and through the appropriate national adverse drug reaction reporting system. This will facilitate observation of trend, and help monitor for associations, informing future research.
Psychological, demographic, illness and treatment risk factors for emotional distress amongst paediatric oncology patients prior to reaching 5‐year survivorship status
Authors: Canning S. , Bunton P. , Talbot Robinson L. 
Published: May 2014

AbstractObjectivesStudies assessing emotional distress severity of paediatric oncology patients prior to reaching 5‐year survivorship status have produced inconsistent findings. This cross‐sectional multi‐centre study aimed to determine psychological, demographic, illness and treatment risk factors for emotional distress in this population.MethodsPaediatric oncology patients (n = 74), aged 12–18 years, completed the Paediatric Index of Emotional Distress, Self‐Description Questionnaire and Paediatric Quality of Life Inventory. Seventy‐two parents provided background information regarding demographics, diagnoses and treatment protocols in addition to appropriate proxy ratings.ResultsHierarchical multiple regression analyses demonstrated that demographic, illness and treatment factors explained little variance in emotional distress. Global self‐concept, global‐generic and cancer‐specific health‐related quality of life (HRQOL) were significant predictors. Provisional multiple regression analyses indicated that pain/hurt, illness‐related worries, communication difficulties and negative self‐views in relation to math abilities, parent relations and opposite‐sex peer relations were risk factors for emotional distress in this sample. Paired‐sample t‐tests and Pearson's moment‐correlation coefficients showed patient and parent reports of patients' self‐concepts and HRQOL were highly consistent.ConclusionsThis study empirically identified modifiable psychological risk factors for emotional distress prior to 5‐year survivorship status and provided guidance for future interventions. Furthermore, findings suggest that parent reports can provide reliable estimates of patients' self‐concepts and HRQOL. Generalizability of the findings was enhanced by the diversity of the sample studied, in terms of diagnosis and treatment exposure, and the multi‐centre recruitment strategy employed. Nevertheless, the findings should be corroborated by larger, longitudinal studies. Copyright © 2014 John Wiley & Sons, Ltd.
The DAN family: Modulators of TGF‐β signaling and beyond
Authors: Nolan Kristof , Thompson Thomas B. 
Published: May 2014

AbstractExtracellular binding proteins or antagonists are important factors that modulate ligands in the transforming growth factor (TGF‐β) family. While the interplay between antagonists and ligands are essential for developmental and normal cellular processes, their imbalance can lead to the pathology of several disease states. In particular, recent studies have implicated members of the differential screening‐selected gene in neuroblastoma (DAN) family in disease such as renal fibrosis, pulmonary arterial hypertension, and reactivation of metastatic cancer stem cells. DAN family members are known to inhibit the bone morphogenetic proteins (BMP) of the TGF‐β family. However, unlike other TGF‐β antagonist families, DAN family members have roles beyond ligand inhibition and can modulate Wnt and vascular endothelial growth factor (VEGF) signaling pathways. This review describes recent structural and functional advances that have expanded our understanding of DAN family proteins with regards to BMP inhibition and also highlights their emerging roles in the modulation of Wnt and VEGF signaling pathways.
Design, synthesis and insecticidal activity of novel 1,1‐dichloropropene derivatives
Authors: Li Jun , Wang Zhen‐Yu , Wu Qiong‐You , Yang Guang‐Fu 
Published: May 2014

AbstractBACKGROUNDPyridalyl is a highly active insecticide against lepidopterous larvae, with a novel chemical structure not related to any other existing insecticide. To discover new pyridalyl analogues with high activity against resistant pests, a series of 1,1‐dichloropropene derivatives bearing structurally diverse substituted heterocycle rings in place of the pyridine ring of pyridalyl were designed and synthesised.RESULTSAll of the title compounds were confirmed by 1H NMR, 13C NMR and high‐resolution mass spectra. Two representative compounds (Ic and IIa) were further characterised by X‐ray diffraction analysis. In addition, bioassays showed that most of the newly synthesised compounds displayed good insecticidal activity against Prodenia litura. Further determination of LD50 values and field trials identified compound IIa as the most promising candidate, which produced a much better 14 day control effect against diamondback moths and longer duration of efficacy than pyridalyl, indicating its potential for further development as a new insecticide for the control of lepidopteran insects.CONCLUSIONCompound IIa has great potential for further development as a new insecticide for the control of lepidopteran insects. © 2014 Society of Chemical Industry
A code offloading scheme for big‐data processing in android applications
Authors: Hung Shih‐Hao , Tzeng Tien‐Tzong , Wu Gyun‐De , Shieh Jeng‐Peng 
Published: May 2014

SummarySmart mobile devices and wireless networks are changing the way people execute applications and access information. In the meantime, more and more personal data are thus spread around different data silos in the Internet. One day, you will find that you may want to access your own data, but the service providers may not allow or the vendors do not provide any application for your need. It means your personal data are locked in by the service vendors. While the advances in the hardware/software technology of the smart mobile devices enable more complicated application than the user can image a couple of years ago, those devices still fall short of big storage, powerful computing and more battery capacity for better user experience. The user may expect a device with secure and unlimited storage for his personal data and run his application as he wishes without incurring more energy consumption. So far, no simple solutions have been proposed to enable compute cloud for code offloading Android application and trusted storage cloud for personal data. The work described in this paper enhances current Android application framework to address the aforementioned issues. We introduce the MobileFBP framework to augment the compute part for the Android device and propose to leverage the central storage part with personal data store, that is, PDS, for trusted usage. In addition to the design and implementation of the enhanced framework, our preliminary experimental results are illustrated as well. Copyright © 2014 John Wiley & Sons, Ltd.
Verbesserungsfaktoren zur Berücksichtigung höherfrequenter Hämmerverfahren beim Ermüdungsnachweis
Authors: Ummenhofer Thomas , Weidner Philipp 
Published: May 2014

AbstractZahlreiche Veröffentlichungen der letzten Jahre unterstreichen das Potenzial höherfrequenter Hämmerverfahren (HFH) zur Steigerung der Ermüdungsfestigkeit geschweißter Stahlbauteile. Auf Grundlage umfangreicher experimenteller Untersuchungen wurden verschiedene Bemessungsempfehlungen für durch HFH‐nachbehandelte Konstruktionsdetails entwickelt. Die meisten dieser Empfehlungen berücksichtigen die Anwendung von HFH beim Ermüdungsnachweis in Form von Verbesserungsfaktoren, durch die die Ermüdungsfestigkeit angehoben wird. Die derzeit verfügbaren Bemessungsempfehlungen basieren auf Ermüdungsversuchen an Serien mit Kleinprüfkörpern, von denen nur wenige eine größere Blechdicke als 15 mm aufwiesen. Dieser Beitrag rezensiert bestehende Bemessungsempfehlungen und erweitert das Bemessungsmodell von Marquis et al. auf Basis eigener Versuchsdaten zur Anwendung im Zusammenhang mit dem Eurocode. Es werden die Konstruktionsdetails Stumpfstoß, Längssteife und Quersteife betrachtet. Auf Grundlage der ausgewerteten Daten werden Verbesserungsfaktoren für axial beanspruchte Kerbdetails für ein Spannungsverhältnis von R = 0,1 gegeben.
Großmaßstäblicher Versuchsstand für zyklisch axial belastete Pfähle
Authors: Baeßler Matthias , Rücker Werner , Cuéllar Pablo , Georgi Steven , Karabeliov Krassimire 
Published: May 2014

AbstractOffshore‐Pfähle in Mehrpfahlgründungsstrukturen wie Jacket‐Gründungen müssen nach der Rammung überwiegend zyklisch axialen Belastungen widerstehen. Die Abmessungen der Pfähle werden sowohl von der inneren Tragfähigkeit und dem Ermüdungsverhalten des Stahlquerschnittes als auch von der äußeren Tragfähigkeit und der Pfahl‐Boden‐Interaktion bestimmt. Aufgrund der großen Zahl von Pfahlgründungen, die für aktuelle und zukünftige Windparkprojekte benötigt werden, besteht ein dringender Bedarf, die Dimensionierung und die damit verbundenen Kosten des Einzelpfahles zu optimieren. Bezüglich der Pfahltragfähigkeit sind wichtige aktuelle Forschungsthemen eine mögliche Traglaststeigerung durch Anwachsen und die geeignete Abschätzung der zyklischen Degradation. Zur Untersuchung beider Effekte wurde eine großmaßstäbliche Versuchsanlage auf dem Testgelände BAM TTS in Horstwalde nahe Berlin errichtet. Auf diesem Versuchsfeld können große Stahlrohrammpfähle zyklisch druck‐ und zugbelastet werden. Zudem kann die Untersuchung von Alterungseffekten durch zeitlichen Versatz zwischen den Messkampagnen untersucht werden. Erste Ergebnisse zeigen einen Anstieg der Pfahltragfähigkeit bis zu ca. 60 % nach einer Standzeit von ca. 18 Monaten. Für die Degradation der Tragfähigkeit der zyklisch belasteten Pfähle zeigen die ersten vorläufigen Ergebnisse ein zum Teil unerwartetes Verhalten. Zusätzliche Untersuchungen werden derzeit zur weiteren Abklärung durchgeführt.
Grouted Connections von Offshore‐Windenergieanlagen
Authors: Schmidt Michael , Fehling Ekkehard , Braun Torsten 
Published: May 2014

AbstractFür die Verbindung zwischen Windenergieanlage und Gründung haben sich im Offshore‐Bereich sogenannte Grouted Connections etabliert. Dabei wird der aus Montage‐ und Toleranzgründen erforderliche Ringspalt zwischen dem oder den Gründungspfählen und der aufgehenden Stahlkonstruktion mit einem hochfesten oder ultrahochfesten Beton (Grout) verfüllt. In Deutschland gibt es für den Bau solcher Anlagen bislang keine bauaufsichtlich zugelassenen technischen Regelwerke. Aus baurechtlichen Gründen ist deshalb eine sog. “Zustimmung im Einzelfall“ der jeweils zuständigen Baubehörde einzuholen. Sie basiert auf den Gutachten unabhängiger Experten und enthält stoffliche Anforderungen, Vorgaben für die Bemessung und qualitätssichernde Maßnahmen sowohl für die Vergussbetone als auch für die Bauausführung. Der Beitrag informiert über die formalen und inhaltlichen Aspekte der Zustimmung im Einzelfall, beschreibt wesentliche Materialaspekte und den Umfang der Qualitätssicherung.
Geotechnische Aspekte bei der Gründungsbemessung von Offshore‐Windenergieanlagen auf Monopfählen mit sehr großen Durchmessern
Authors: Kirsch Fabian , Richter Thomas , Coronel Maria 
Published: May 2014

AbstractDie Bemessung von Stahlrohren als Monopfahlgründung von Offshore‐Windenergieanlagen (OWEA) basiert zu einem ganz wesentlichen Anteil auf der wirklichkeitsnahen Abbildung der Bettungsreaktion der überwiegend lateral‐zyklisch belasteten Pfähle. Dabei gilt es, sowohl die Bodenreaktion bei kleinen Dehnungen zur Abschätzung der dynamischen Steifigkeiten als auch die räumliche Wirkung des Erdwiderstandes zur Abschätzung der lateralen Tragfähigkeit korrekt abzubilden. Darüber hinaus muss berücksichtigt werden, wie die wechselnde Beanspruchung das Zweiphasengemisch aus Korngerüst und Porenwasser beeinflusst, um sowohl die akkumulierten Verformungen als auch die Standsicherheit mit ausreichender Genauigkeit zu erfassen. Im vorliegenden Beitrag wird gezeigt, wie die herkömmlichen, für Pfähle der aktuell zu planenden Abmessungen jedoch nicht ausreichenden Ansätze modifiziert werden müssen, um ein sicheres und wirtschaftliches Design zu ermöglichen.
Tuneable resolution as a systems biology approach for multi‐scale, multi‐compartment computational models
Authors: Kirschner Denise E. , Hunt C. Anthony , Marino Simeone , Fallahi‐Sichani Mohammad , Linderman Jennifer J. 
Published: May 2014

The use of multi‐scale mathematical and computational models to study complex biological processes is becoming increasingly productive. Multi‐scale models span a range of spatial and/or temporal scales and can encompass multi‐compartment (e.g., multi‐organ) models. Modeling advances are enabling virtual experiments to explore and answer questions that are problematic to address in the wet‐lab. Wet‐lab experimental technologies now allow scientists to observe, measure, record, and analyze experiments focusing on different system aspects at a variety of biological scales. We need the technical ability to mirror that same flexibility in virtual experiments using multi‐scale models. Here we present a new approach, tuneable resolution, which can begin providing that flexibility. Tuneable resolution involves fine‐ or coarse‐graining existing multi‐scale models at the user's discretion, allowing adjustment of the level of resolution specific to a question, an experiment, or a scale of interest. Tuneable resolution expands options for revising and validating mechanistic multi‐scale models, can extend the longevity of multi‐scale models, and may increase computational efficiency. The tuneable resolution approach can be applied to many model types, including differential equation, agent‐based, and hybrid models. We demonstrate our tuneable resolution ideas with examples relevant to infectious disease modeling, illustrating key principles at work. WIREs Syst Biol Med 2014, 6:225–245. doi: 10.1002/wsbm.1270This article is categorized under:

Analytical and Computational Methods > Computational Methods
Analytical and Computational Methods > Dynamical Methods
Models of Systems Properties and Processes > Mechanistic Models
Three Transition Metal(II) Coordination Polymers Constructed by a Semi‐rigid Bis‐pyridyl‐bis‐amide and Dicarboxylates Mixed Ligands: Assembly, Structures and Properties
Authors: Lin Hong‐Yan , Luan Jian , Wang Xiu‐Li , Liu Guo‐Cheng , Zhang Ju‐Wen 
Published: May 2014

AbstractThree coordination polymers, namely [Co(BDC)(L)]·H2O (1), [Co(NPH)(L)]·H2O (2), and [Ni(NPH)(L)(H2O)3]·H2O (3) [H2BDC = 1, 3‐benzenedicarboxylic acid, H2NPH = 3‐nitrophthalic acid, L = N,N′‐bis(3‐pyridyl)‐terephthalamide] were hydrothermally synthesized by self‐assembly of cobalt/nickel chloride with a semi‐rigid bis‐pyridyl‐bis‐amide ligand and two aromatic dicarboxylic acids. Single crystal X‐ray diffraction analyses revealed that complexes 1 and 2 are two‐dimensional (2D) coordination polymers containing a one‐dimensional (1D) ribbon‐like Co‐dicarboxylate chain and a 1D zigzag Co‐L chain. Although the coordination numbers of CoII ions and the coordination modes of two dicarboxylates are different in complexes 1 and 2, they have a similar 3, 5‐connected {42.67.8}{42.6} topology. In complex 3, the adjacent NiII ions are linked by L ligands to form a 1D polymeric chain, whereas the 1D chains does not extend into a higher‐dimensional structure due to the ligand NPH with monodentate coordination mode. The adjacent layers of complexes 1 and 2 and the adjacent chains of 3 are further linked by hydrogen bonding interactions to form 3D supramolecular networks. Moreover, the thermal stabilities, fluorescent properties, and photocatalytic activities of complexes 1–3 were studied.
Structural Implications of Spin, Charge, and Orbital Ordering in Rubidium Sesquioxide, Rb4O6
Authors: Sans Annette , Nuss Jürgen , Fecher Gerhard H. , Mühle Claus , Felser Claudia , Jansen Martin 
Published: May 2014

Abstract Rb4O6 displays mixed valency on the anionic lattice and an open p‐shell electronic configuration. At ambient conditions, it exists in a disordered ground state structure, featuring three different potential ordering parameters related to phase transitions driven by charge, orbital and spin ordering. The possible paths of symmetry descent are analyzed by elaborating the respective group‐subgroup relations between space groups, including the implications that would result from magnetic ordering. Experimentally, a lower symmetry modification was discovered and characterized by single‐crystal X‐ray diffraction [I$\bar{4}$, Z = 4, a = 8.688(6), c = 10.362(7) Å, R1 = 0.055, 787 independent reflections]. The symmetry reduction involved follows one branch of the Bärnighausen tree as predicted, I$\bar{4}$3d → I$\bar{4}$2d → I$\bar{4}$ convincing evidence was obtained for Rb4O6 undergoing charge and orbital ordering, along with respective structural order.
Das myofasziale Schmerzsyndrom
Authors: Gautschi R. , Böhni U. 
Published: May 2014

Zusammenfassung

Hintergrund
Schmerzen und/oder Funktionsstörungen, wie Schwäche oder Bewegungskontrollstörungen, sind häufig myofaszial verursacht. Das pathophysiologische Substrat myofaszialer Probleme sind myofasziale Triggerpunkte (mTrP) und reaktive Bindegewebsveränderungen. Typisch für myofaszialen Schmerzen ist, dass der Ort der Schmerzursache und der Ort der Schmerzwahrnehmung oft nicht an derselben Stelle liegen („referred pain“). Myofasziale Störungen können primär oder sekundär verursacht sein; häufig tragen sie wesentlich zu Reizsummationsproblemen bei. Im Prozess des „clinical reasoning“ ist zu erkunden, welchen Stellenwert mTrP und Faszienveränderungen für das konkret vorliegende Problem haben (z. B. primär, sekundär, Beitrag zur Reizsummation).

Methoden
Die kausale und nachhaltige Therapie myofaszialer Störungen behandelt je nach Notwendigkeit sowohl die kontraktilen Teile des Muskels (Kontrakturknoten) als auch die nichtkontraktilen Anteile (reaktive Bindegewebsveränderungen). Je nach vorliegender Situation müssen prädisponierende und aufrechterhaltende Faktoren erkannt und nach Möglichkeit in die Therapie mit einbezogen werden. Die Triggerpunkt-Therapie IMTT® (Interessengemeinschaft für Myofasziale Triggerpunkt-Therapie) umfasst manuelle Techniken und ggf. Dry Needling zur Deaktivierung des Störpotenzials der mTrP, Dehnen/Detonisieren und funktionelles Training bzw. Ergonomie.
FBG stress-sensibilized monitor for railway switch pole on-line monitoring
Authors: Li Weilai , Liu Jie , Pan Jianjun , Pang Jin , Lu Xiaoshan 
Published: May 2014

Abstract
The fiber Bragg grating (FBG) sensing technology is used to dynamically monitor multiple parameters of railway switch machine poles, including time of movement, direction and quantity of loading and locking force, and states of loading resistance. This paper presents the design and implementation of a railway switch pole strain on-line monitoring system based on the FBG stress-sensibilized monitor for a Siemens S700K switch machine. The ring shape FBG strain gauge and stress-sensibilized methods significantly increased the monitoring sensitivity. Installing approaches adapted the harsh environment in the railway application. The monitoring results showed the high sensitivity and high reliability of this monitoring system. This application provides a long-term and on-line detecting method which could meet railway switch condition monitoring demands of more than 100,000 switch machines in the country.
Leukemia during pregnancy
Authors: Saleh AJM , Alhejazi Ayman , Ahmed Syed Osman , Mohareb Fahad Al , AlSharif Fahad , AlZahrani Hazza , Mohamed Said Yousuf , Rasheed Walid , AlDawsari Ghuzayel , Ibrahim Khalid , Ahmed Shad , Chebbo Wahiba , ElGohary Ghada , Almahayni Muhamad , Chaudhri Naeem , Aljurf Mahmoud 
Published: May 2014

BACKGROUND AND OBJECTIVES:
There is limited information regarding the outcome of patients treated for leukemia during pregnancy. This study was performed on all cases of leukemia during pregnancy identified in our institution leukemia database.

PATIENTS AND METHODS:
It is a retrospective study from our existing database. Thirty two cases were identified among the cohort of patients treated for acute and chronic leukemia between January 1991 and July 2003.

RESULTS:
Among the acute leukemia patients (n = 21), 10 patients (47.6%) received chemotherapy during pregnancy, seven had live birth and three had spontaneous abortion. No teratogenicity or congenital malformations or postnatal complication were reported. The remaining 11 (52.4%) were not given chemotherapy while pregnant; three patients presented after 34 weeks of gestation ending in normal live births and then received chemotherapy and eight patients had abortion before starting chemotherapy.Among the chronic myeloid leukemia (CML) patients (n = 11), nine patients received hydroxyurea, one patient received alfa-interferon and one patient was treated with leukapheresis. Eight patients had normal live births and three patients had abortion. Out of the 32 patients, 18 patients (56.2%) subsequently underwent HLA matched sibling allogeneic stem cell transplantation, seven for acute myeloid leukemia (AML), two for acute lymphocytic leukemia (ALL) and nine for CML. After a median follow up of 16 years, five patients (15.6%) are alive in remission (one fromchemotherapy group and four from SCT group).

CONCLUSIONS:
Our report lends credence to the safety and feasibility of administering anti-leukemic therapy in acute and chronic leukemias during pregnancy although acute leukemia patients had possibly a poor long term outcome compared to non-pregnant patients.