bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epithets in Vasyl Shklyar’s language creation (lexicographic form of study based on the material of the work of fiction «Kharakternyk»)
Authors: Kolomiiets Inna , Rozghon Valentyna 
Published: July 2024

Lexicographic register of the fiction and author's palette of means of verbal expression of characteristic features, signs, properties of external portraiture of a person, recorded by the method of continuous sampling from V. Shklyar’s historical novel «Kharakternyk», was carried out in the article. Moreover, the semantic and stylistic approach to the study of existing figurative idioms was implemented, the lexical and grammatical typology as well as artistic and aesthetic representation of the analyzed forms were clarified, which reproduce the anthropocentric vector of the author’s artistic thinking through the point of his national and linguistic worldview.
The thematic group «Human appearance» primarily consists of key lexical nominations of portrait characteristics, such as: eyebrow (eyebrows), upper eyebrow; moustache (moustache); lip (lips), mouth; hair, topknot, chub; palm; nose; leg (legs); eyes. All of them have an unequally productive combination with signifying lexemes, are characterized by moderate or distinctly bright connotative qualities of their semantics and play a peculiar artistic and descriptive, ornamental, evaluative and aesthetic or emotional and expressive role in the text of this novel.
A significant number of epithets belong to the artistic and aesthetic ornamentation and figurative attributes of the concepts moustache, eyes, and are united around a striking similarity, figural juxtaposition according to lexical and thematic relations – shape, size, color, tactile feelings, emotional sphere, etc. This can be seen in detail in the presentation of the material of our lexicographic attempt to describe epithet compounds.
The list of artistically disparate epithets attests to the use of a common language set of permanent, traditional lexical signs, their identification of the usual figurative characteristics of a person’s appearance, and thus – a reflection of the features of the psychotype and behavior of the depicted characters – as well as the construction of updated, expanded qualitative originality of the author’s aesthetics of world perception and communicative practice, from the more familiar ones to individually actualized, precise, apt and distinctly unexpected epithets in terms of structure and artistic and aesthetic endowment.
Effects of black vinegar, Kurozu, on chromatin modifications and microRNA expression in the mouse liver
Authors: Shibayama Yoshihiko , Fujii Akira , Fujimoto Yuki , Hamada Kensaku 
Published: July 2024

Background: Kurozu is a traditional Japanese rice vinegar characterized by its brown color and that has been shown to improve hypertension, hypercholesterolemia, and carbohydrate metabolism. Kurozu has also been suggested to confer health benefits by altering gene expression; however, the molecular basis is not yet understood.
Objective: We previously reported that the intake of Kurozu increased the expression hepatic Sirt1 and microRNA (miR). These changes in gene expression may be attributed to histone modifications. Therefore, the current research explored the effects of supplementation with concentrated Kurozu (CK) on histone modifications in the liver.
Methods: Over a period of 50 weeks, mice received a high-fat diet (HFD), HFD with CK, or a standard diet (SD). The study focused on the impact of CK on gene expression related to lipid metabolism in the liver.
Results: A microarray analysis revealed that HFD increased the expression of the miR cluster located on chromosome 12, while this change was suppressed by CK. The chromatin modification region upstream of the miR cluster was analyzed using a Chip assay. HFD significantly increased the levels of dimethylation of histone H3 lysine 4 (H3K4me2) and monoacetylation of histone H3 lysine 27 (H3K27ac). HFD also increased H3K4me2 levels, and this change was inhibited by HFD with CK. MiR-127-5p and -134-5p, which are present in the miR cluster, inhibited MLXIPL, a transcription factor involved in synthesizing fatty acids from carbohydrates. Further experiments with human colon cancer cells demonstrated that miR-127-5p and -134-5p significantly knocked down MLXIPL.
Conclusion: These results suggested that HFD affects miR expression levels by changing chromatin modification levels and that supplementation with CK suppressed HFD-induced increases in H3K4me2 levels. Furthermore, HFD upregulated the expression of miR-127-5p and -134-5p, which in turn suppressed MLXIPL.
Keywords: chromatin modification, genomic imprinting, high-fat diet, Kurozu, microRNA, MLXIPL
From Awareness to Action: Fostering Inclusivity for Students with Disabilities
Authors: Lahmiyed Yousra , Najib Slimani  , Khadija Anasse  
Published: July 2024

This study aims to investigate the process of fostering inclusivity for children with autism spectrum disorder (ASD) within educational contexts, with a specific focus on understanding the efficacy of Applied Behavior Analysis (ABA) and Assessment of Basic Language and Learning Skills (ABLLS) programs. It draws from experiences gained through collaboration with professionals and parents at the Princesse Lalla Meryem Pour Enfants Autistes Institute in Tangier. Set within the dynamic landscape of Morocco's disability support and education sector, this research unfolds within the framework of the Princesse Lalla Meryem Pour Enfants Autistes Institute in which ABA and ABLLS programs are used extensively, complemented by individualized support provided by dedicated assistants for each student. Furthermore, cognitive behavioral therapy is integrated into the educational approach. The overarching goal of the organization is to equip children with ASD with the necessary skills to integrate successfully into mainstream educational institutions. By employing a participatory action research methodology, this study engages closely with professionals, parents, and autistic students. Qualitative interviews, observations, and collaborative reflections serve as key methods to understand the nuances and effectiveness of ABA, ABLLS, and cognitive behavioral therapy in fostering inclusivity. Initial findings highlight the pivotal role of individualized support and evidence-based interventions such as ABA, ABLLS, and cognitive behavioral therapy in promoting the inclusion of children with ASD. Insights gleaned from the experiences of both professionals and parents shed light on promising practices and areas for further enhancement in preparing autistic children for successful integration into mainstream educational institutions. This study enriches the existing literature by providing firsthand insights into the practical applications of ABA, ABLLS, and cognitive behavioral therapy within the context of an inclusive educational organization in Morocco. By bridging theory and practice along with incorporating diverse perspectives, the study aims to inform the development of more effective inclusive policies and practices, ultimately contributing to the successful integration of children with ASD into mainstream educational settings.
АНАЛІЗ ДІЯЛЬНОСТІ ІНКЛЮЗИВНО-РЕСУРСНИХ ЦЕНТРІВ В УКРАЇНІ В УМОВАХ ВІЙНИ
Authors: Сушко Павло , Прохоренко Леся 
Published: July 2024

У статті обґрунтовано, що в умовах війни в Україні виникли серйозні виклики в системі освіти осіб з особливими освітніми потребами. Інклюзивно-ресурсні центри, які спеціалізуються на підтримці осіб з особливими потребами та інших вразливих груп громадян, відіграють критичну роль у забезпеченні доступу до якісної освіти, ресурсів та підтримки, особливо під час військових дій.
Дослідження роботи інклюзивно-ресурсних центрів в умовах війни в Україні дало змогу виявити потреби цих центрів, виклики, з якими вони зіштовхуються, а також сформувати шляхи покращення їхньої діяльності. Розкрито мету створення таких установ та завдання, які вони покликані вирішувати. З’ясовано наявний стан діяльності мережі інклюзивно-ресурсних центрів в Україні. За даними опитування, виявлено низку проблем в діяльності ІРЦ, зокрема: неузгодженість нормативно-правових актів, які регулюють діяльність ІРЦ; перевантаження наявного ресурсу ІРЦ, зокрема кадрового (брак фахівців; фахівці, які залишилися, виконують роботу, що охоплює всю сферу послуг для населення (іноді це один чи два фахівці); складність у виконанні комплексної оцінки і супровід внутрішньо переміщених дітей з особливими освітніми потребами та підтримку їх батьків (кількість ВПО значно більша, ніж в інших, що впливає на спроможність ІРЦ та часто потребує розширення їх мережі); брак фінансування (розподіл коштів субвенцій та місцевого бюджету між ІРЦ залежить від рішень громади, тому в різних громадах різна фінансова підтримка ІРЦ) тощо. Доведено, що мережа інклюзивно-ресурсних центрів продовжує розвиватися задля доступності послуг, які вони надають дітям і їхнім родинам. Проаналізовано інноваційні сервіси та онлайн-ресурси надання відповідних послуг та наголошено на потребі їх вдосконалення.
У висновку зроблено припущення, що отримані дані дослідження можуть сприяти розробленню політик та програм, спрямованих на підтримку інклюзивності та соціальної справедливості в умовах війни.
Management difficulties in a patient with post-traumatic stress disorder and role of trauma focused cognitive behavior therapy
Authors: Hasan Mohammad , Singha Romendra Kumar , Roy Susmita , Arifuzzaman Md 
Published: July 2024

Post-traumatic stress disorder is not uncommon but in practical ground it is really difficult to treat these patients. Multiple treatment options are in hand but psychological treatment is the first recommendation. Initially after the exposure or incident symptoms may be severe. In case of severe agitation, self-destructing behavior, intense psychological distress, extreme sleep disturbances or anger outbursts, pharmacological intervention as early as possible is needed. Stress coping skills, relaxation therapies, psychological first aid and trauma focused cognitive behavior therapy (CBT) are important to treat the patient and get back full functional state. Prevention of suicide and self-harm is vital. Risk assessment, presence of hostility and complete personal history guide psychiatrist to take measures. The case described below was a good example resolution by trauma focused CBT. In this case patient had severe symptoms, aggression and self-destructive behavior. By using pharmacological intervention and using all available resources of psychological therapy, patient improved.
Bang J Psychiatry 2023;37(1): 20-22
Exploring mental health needs, coping and suitable service modalities for people affected by coronavirus disease 19
Authors: Tamanna Fairuz Hossain , Anik Asibul Islam , Faruk Md Omar , Jahan Rubina , Mozumder Muhammad Kamruzzaman , Selim Ashique 
Published: July 2024

There was a general gap on coronavirus disease (COVID) 19 related mental health concerns and coping data from the peak period of pandemic. With the aim of ensuring evidence informed service delivery, this study explored mental health needs, coping mechanisms and preferred service modalities of the front-line healthcare workers (FLHWs), COVID 19 patients and family members of both patients and FLHWs. Sixty-three participants were included in this cross-sectional study which was conducted at the period from July 2020 to December 2020. The FLHWs and patients were recruited using purposive sampling from a COVID 19 dedicated hospital in Narayanganj while the family members were selected through the contact detailed shared by the FLHWs and the patients. Three mental health professionals conducted the interviews over the phone using a semi-structured qualitative interview guide. The findings of the study were presented in three broad categories, namely a) concerns around psychosocial health and wellbeing, b) coping with COVID 19 and its impacts and c) preferred modalities for psychosocial service delivery. The results showed that, low mood was most common (68.3%) followed by irritability and anger (65.1%) and concerns about the future (61.9%) among the participants. A very high number of participants (74%) reported an increase in religious activity and faith. As strategies to cope with the pandemic crisis, the participants most commonly reported engagement in entertainment (27%), taking care of relationships (21%) and engagement in spirituality (17%). The most preferred modality of service was self-help materials (49%; online videos, booklets, posters/leaflets) followed by webinars (12%) and online counselling (10%). However, to enable evidence informed service delivery during any severe pandemic such as COVID 19, the mental health needs of FLHWS and their family members must be addressed.
Bang J Psychiatry 2023;37(2):38-45
Subacute sclerosing panencephalitis with disorganized behavior: a case report from psychiatry ward
Authors: Rahman Mahabuba , Syed Sifat E , Morshed Nahid Mahjabin , Chowdhury Hafizur Rahman 
Published: July 2024

Subacute sclerosing panencephalitis (SSPE) is a late onset, rare and slowly progressive viral encephalitis with a mandatory fatal outcome. The disease initially presents with myoclonic jerks and seizures, ocular manifestations, cognitive decline and behavioral disturbances. However, few rare cases of SSPE had been reported with the initial presentation of sole psychiatric symptoms creating a diagnostic dilemma. We hereby reported a case of an 18 years-old male presented with a history of disorganized behavior who was further evaluated as a case of SSPE. The importance of a holistic approach to rule out organic causes before diagnosing a psychiatric disorder had been highlighted in this report.
Bang J Psychiatry 2023;37(2): 49-51
A review of β-caryophyllene oxide for its pharmacological properties supported by in silico findings
Authors: Kamal A T M Mostafa 
Published: July 2024

Bicyclic sesquiterpene, β-caryophyllene oxide (BCO) is one of the major components of essential oil derived from aromatic plants. It is reported to possess several interesting pharmacological prospects. BCO’s ability to suppress a few signaling cascades and down regulating various gene products responsible for cancer development against several cancer cell lines was seen along with some analgesic properties. Besides, its interaction with enzymes responsible for metabolism of the drugs performed in-vitro and in-vivo was found to show diminishing and enhancing effects on the enzymes. All the possible relevant published articles on BCO were collected using some popular search engines such as Google Scholar, Pubmed, ScienceDirect etc. The molecular docking was carried out with the help of Schrodinger Suites-Maestro 2017-1. In addition, the in-silico findings also provided strong evidence in favor of BCO with the ability to be a prospective therapeutic agent. However, from all the information gathered on this compound and clinical trials, this compound may yield beneficial results novel drug discovery.
IIUC Studies Vol.19, December 2022: 87-120
Strategi Sistem Jemput Bola Dalam Meningkatkan Motivasi Menabung Nasabah Pada BMT UGT Nusantara Cabang Kediri
Authors: K. Khairan K. Khairan 
Published: July 2024

Abstrak
Strategi merupakan metode yang digunakan dalam mencapai suatu tujuaan. Strategi juga dilakukan oleh Bank Syariah seperti Baitul Maal wa Tamwil dalam mengembangkan lembaga dan menarik nasabah. Salah satu strategi yang dapat dilakukan adalah jemput bola. Strategi jemput bola dilakukan dengan mendatangi nasabah untuk bergabung dan menabung dengan BMT UGT Nusantara Cabang Kediri. Tujuan penelitian ini adalah untuk mengetahui strategi jemput bola dalam meningkatkan motivasi menabung pada BMT UGT Nusantara Cabang Kediri. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pengambilan data observasi dan wawancara. Hasil dari penelitian ini bahwa BMT UGT Nusantara Cabang Kediri menghadirkan sistem tabungan dalam menarik dan menghimpun nasabah. Untuk memotivasi nasabah menabung di BMT UGT Nusantara Cabang Kediri menggunakan sistem jemput bola, yang mana petugas menemui nasabah secara langsung untuk memudahkan nasabah melakukan transaksi.

Kata Kunci: Strategi, Jemput Bola, Motivasi, dan Menabung
From waste to wonder: exploring the hypoglycemic and anti-oxidant properties of corn processing by−products
Authors: Yang Xiaoqian , Wang Yuelong , Li Jingfeng , Tai Yuxing , Yang Kunping , Lv Jingwei , Sun Jiaming , Zhang Hui 
Published: July 2024

Introduction: The industrial processing of corn (Zeamays L.) generates by-products such as corn silk, straw peels, and straw core, which contribute to adverse environmental impacts. Our study aimed to investigate sustainable approaches for mitigating these effects by evaluating the hypoglycemic potential and mechanisms of ethyl acetate fractions derived from these corn derivatives.Methods: We employed glucose consumption assays, high glucose stress tests, UPLC-QE-Orbitrap-MS analysis, molecular docking, and simulations to assess their components and efficacy. Antioxidant capacities were evaluated using DPPH, FRAP, ABTS, and •OH scavenging assays.Results: Notably, the ethyl acetate fraction extracted from straw peels (SPE) exhibited a high concentration of flavonoids and phenolic compounds along with pronounced hypoglycemic activity and antioxidant capacity. SPE significantly enhanced glucose consumption in insulin-resistant HepG2 cells while protecting HUVECs against damage caused by high glucose levels. Molecular docking analyses confirmed the interaction between active compounds and α-glucosidase as well as α-amylase, while molecular dynamic simulations indicated stability at their binding sites.Discussion: In conclusion, the hypoglycemic and antioxidative properties observed in corn by-products such as straw peels, corn silk, and straw core can be attributed to the inhibition of α-glucosidase and α-amylase activities, coupled with their rich phenolic and flavonoid content. These findings highlight the potential of these by-products for applications in healthcare management and their sustainable utilization, demonstrating significant value in the use of agricultural residues.
Gaining new insights into the etiology of ulcerative colitis through a cross-tissue transcriptome-wide association study
Authors: Ren Shijie , Sun Chaodi , Zhai Wenjing , Wei Wenli , Liu Jianping 
Published: July 2024

BackgroundGenome-wide association studies (GWASs) have identified 38 loci associated with ulcerative colitis (UC) susceptibility, but the risk genes and their biological mechanisms remained to be comprehensively elucidated.MethodsMulti-marker analysis of genomic annotation (MAGMA) software was used to annotate genes on GWAS summary statistics of UC from FinnGen database. Genetic analysis was performed to identify risk genes. Cross-tissue transcriptome-wide association study (TWAS) using the unified test for molecular signatures (UTMOST) was performed to compare GWAS summary statistics with gene expression matrix (from Genotype-Tissue Expression Project) for data integration. Subsequently, we used FUSION software to select key genes from the individual tissues. Additionally, conditional and joint analysis was conducted to improve our understanding on UC. Fine-mapping of causal gene sets (FOCUS) software was employed to accurately locate risk genes. The results of the four genetic analyses (MAGMA, UTMOST, FUSION and FOCUS) were combined to obtain a set of UC risk genes. Finally, Mendelian randomization (MR) analysis and Bayesian colocalization analysis were conducted to determine the causal relationship between the risk genes and UC. To test the robustness of our findings, the same approaches were taken to verify the GWAS data of UC on IEU.ResultsMultiple correction tests screened PIM3 as a risk gene for UC. The results of Bayesian colocalization analysis showed that the posterior probability of hypothesis 4 was 0.997 and 0.954 in the validation dataset. MR was conducted using the inverse variance weighting method and two single nucleotide polymorphisms (SNPs, rs28645887 and rs62231924) were included in the analysis (p &lt; 0.001, 95%CI: 1.45-1.89). In the validation dataset, MR result was p &lt; 0.001, 95%CI: 1.19-1.72, indicating a clear causal relationship between PIM3 and UC.ConclusionOur study validated PIM3 as a key risk gene for UC and its expression level may be related to the risk of UC, providing a novel reference for further improving the current understanding on the genetic structure of UC.
Effect of early administration of dexamethasone in patients with COVID-19 pneumonia without acute hypoxemic respiratory failure and risk of development of acute respiratory distress syndrome: EARLY-DEX COVID-19 trial
Authors: Franco-Moreno Anabel , Acedo-Gutiérrez María Soledad , Casado-Suela Miguel Ángel , Labrador-San Martín Nicolás , de Carranza-López María , Ibáñez-Estéllez Fátima , Hernández-Blanco Clara , Jiménez-Torres José , Vallejo-Maroto Ignacio , Romero-Pareja Rodolfo , Peña-Lillo Gabriela , Escobar-Rodríguez Ismael , Torres-Macho Juan ,   EARLY-DEX COVID-19 Research Group
Published: July 2024

Introduction and objectivesCorticosteroids are among the drugs demonstrating a mortality benefit for coronavirus disease 2019 (COVID-19). The RECOVERY trial highlighted that dexamethasone reduced 28-day mortality for hospitalized COVID-19 patients requiring either supplemental oxygen or mechanical ventilation. It is noted that approximately 30% of COVID-19 patients, initially presenting with mild symptoms, will advance to acute respiratory distress syndrome (ARDS), especially those with detectable laboratory markers of inflammation indicative of disease progression. Our research aimed to explore the efficacy of dexamethasone in preventing the progression to ARDS in patients hospitalized with COVID-19 pneumonia who do not yet require additional oxygen but are at high risk of developing ARDS, potentially leading to a reduction in morbimortality.MethodsIn this multicenter, randomized, controlled trial, we evaluated the impact of dexamethasone on adult patients diagnosed with COVID-19 pneumonia who did not need supplementary oxygen at admission but were identified as having risk factors for ARDS. The risk of ARDS was determined based on specific criteria: elevated lactate dehydrogenase levels over 245 U/L, C-reactive protein levels exceeding 100 mg/L, and a lymphocyte count below 0.80 × 109/L. Participants were randomly allocated to either receive dexamethasone or the standard care. The primary endpoints included the incidence of moderate or severe ARDS and all-cause mortality within 30 days post-enrollment.ResultsOne hundred twenty-six patients were randomized. Among them, 41 were female (30.8%), with a mean age of 48.8 ± 14.4 years. Ten patients in the dexamethasone group (17.2%) and ten patients in the control group (14.7%) developed moderate ARDS with no significant differences. Mechanical ventilation was required in six patients (4.7%), with four in the treatment group and two in the control group. There were no deaths during hospitalization or during follow-up. An intermediate analysis for futility showed some differences between the control and treatment groups (Z = 0.0284). However, these findings were within the margins close to the region where the null hypothesis would not be rejected.ConclusionIn patients with COVID-19 pneumonia without oxygen needs but at risk of progressing to severe disease, early dexamethasone administration did not lead to a decrease in ARDS development.Clinical trial registrationClinicalTrials.gov, identifier NCT04836780.