bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triple-layer sulfonated poly(ether ether ketone)/sulfonated polyimide membranes for fuel cell applications
Authors: Li Xiaobai , Song Yang , Liu Zhuang , Feng Pengju , Liu Siyuan , Yu Yunwu , Jiang Zhenhua , Liu Baijun 
Published: August 2013

A series of triple-layer membranes were prepared based on a sulfonated polyimide (SPI) and a traditional sulfonated poly(ether ether ketone) (SPEEK) polymer matrix. Compared with the single-component membranes (pure SPI and SPEEK), the multicomponent membranes exhibited better comprehensive performance. Interestingly, the triple-layer membranes possessed improved mechanical properties, lower water uptake, and swelling ratio than those of the corresponding blend membranes. When the contents of SPI were 30 and 40%, the triple-layer membranes even had lower methanol permeability (3.42 and 2.61 × 10−7 cm2 s−1, respectively) than that of the pure SPI membrane (3.51 × 10−7 cm2 s−1). The proton conductivity of the triple-layer membranes was in the range of 0.117–0.149 S cm−1 at 100°C. All the results suggest that the triple-layer membranes have sufficiently excellent performance to be applied in fuel cells.
Trends in control of cardiovascular risk factors among US adults with type 2 diabetes from 1999 to 2010: Comparison by prevalent cardiovascular disease status
Authors: Wong Nathan D , Patao Christopher , Wong Kalina , Malik Shaista , Franklin Stanley S , Iloeje Uchenna 
Published: August 2013

Background: Most patients with type 2 diabetes mellitus (T2DM) suffer from cardiovascular disease (CVD). Whether CVD risk factors have improved in those with DM with and without CVD is not established. We compared risk factor levels and goal attainment in US adults with diabetes with and without CVD. Methods: We examined 2403 adults (aged ≥ 18 years) in the United States with T2DM ( n = 654, 27% with CVD) across 1999–2010 using the US National Health and Nutrition Examination Survey (NHANES) and evaluated control of hemoglobin A1c (HbA1c), blood pressure (BP), low-density lipoprotein cholesterol (LDL-C) and body mass index (BMI) in those with DM with versus without CVD. Results: The proportions controlled for HbA1c, BP and LDL-C have improved ( p < 0.001) overall between 1999 and 2010, but only 24% were at goal for all three factors in 2009–2010. There were improvements in BP, triglycerides and LDL-C in those with CVD, and in those without CVD, there were also improvements in control of all parameters, although changes in mean levels of risk factors were less impressive. Conclusion: Despite modest improvement over time, in most CVD risk factors, only one-fourth of those with T2DM are at goal for HbA1c, BP and LDL-C, with improvements seen in those without CVD more often than those with CVD.
Leaning in and Leaning Back at the Same Time
Authors: Dirkx John M. 
Published: August 2013

The Problem The spirituality of work movement placed emphasis on the importance of meaning and purpose in work and the workplace. However, the spiritual dimensions of work-related learning remained largely undeveloped. Given recent economic developments that threaten to undo any gains achieved by this movement, it is important that human resource development (HRD) help individuals and organizations learn to engage in the inner learning that creates deep meaning and purpose in our work. The Solution This article locates work-related learning within the spirituality of work context. Using Jungian and post-Jungian psychology, the article provides a theoretical perspective for thinking about meaning and purpose in work-related learning and the key features of educational and organizational environments that foster such learning and development. The Stakeholders The perspective developed in this article will be helpful to teachers, trainers, and HRD practitioners involved in formal work-related learning programs, as well as coaches and developmental managers who seek to foster learning and development among their workers.
Human Agency and HRD
Authors: Kuchinke K. Peter 
Published: August 2013

The Problem Human resource development (HRD) research and theories often do not adequately capture the holistic and self-directed nature of human beings at work. Likewise, HRD practice can fall short when applying an instrumental stance toward individuals as resources instead of building on the innate strengths and intrinsic areas of interest. The Solution The concept of human agency is explored in this article in contrast to narrow and instrumental understandings of the person to propose an ethically and pragmatically more adequate notion for HRD research and practice. Exploring essential elements of human and moral agency affords a view of how individuals might understand themselves in the context of work and opens up the opportunity to build HRD theory and practice based on a holistic understanding of persons. The Stakeholders This article has relevance for future practitioners and researchers in university-based HRD programs, for HRD scholars seeking to advance the art and science of the field, and for HRD managers and professionals responsible for the learning and education system and processes in organizations and other work settings.
Leading Individual Development and Organizational Change Around Learning, Meaning, and Nurturing Environment
Authors: Boverie Patricia , Grassberger Robert , Law Victor 
Published: August 2013

The Problem Today’s organizations compete for top talent in a global marketplace. Employees seek work that is interesting and meaningful, where they can be engaged and continuously learning. While much is written about employee engagement, leaders need a model for structuring workplaces where employees can be passionate about their work and where there are opportunities for employees to learn and grow. The Solution This article contends that the time is right for developing workplaces that are humane, positive, and challenging. Drawing on the Organizational Intimacy (OI) framework and incorporating ideas from positive psychology, leaders can create positive environments by promoting a nurturing workplace, encouraging meaningful work, and fostering environments where employees love their work. The Stakeholders The primary stakeholders for this article are senior leaders and Human Resource and Organizational Development practitioners seeking to build humane and positive workplaces. In addition, HRD scholars studying frameworks that incorporate ideas from positive psychology will also find this article of interest.
Avastin and Lucentis: what do patients know? A prospective questionnaire survey
Authors: Manna Avinash , Oyede Oluwatoyin , Ning Brigid , Yang Yit , Narendran Niro 
Published: August 2013

Objectives To assess patients’ knowledge of their drug therapy for neovascular macular degeneration and to identify which aspects of the drug they considered most important if given the option of switching to an alternative drug. Design Prospective questionnaire survey. Setting Wolverhampton, England. Participants A total of 126 patients attending our hospital service for intravitreal ranibizumab therapy for neovascular macular degeneration. Main outcome measures Using a questionnaire, patients were asked questions pertaining to aspects of drug therapy in neovascular macular degeneration. Fields covered included drug names, knowledge of alternative drugs, cost of drugs and their views on switching to another drug. Results Eighty (63.5%) had heard of Lucentis (ranibizumab) and 31 (24.6%) were aware of Avastin (bevacizumab). Of the latter 31 patients, 20 did not have a preference between Avastin and Lucentis. These patients felt that the factors they would consider important for them to consider switching were effectiveness (10, 50%), specialist recommendation (8, 40%), safety (2, 10%) and cost (0). Conclusions Introducing a cheaper, off-label alternative in the therapy of macular degeneration in the presence of a licensed option has been extensively debated. Many patients have no knowledge of this controversial issue but it is likely that efficacy and recommendation by clinicians are more important than cost to patients who may consider switching to the off-label Avastin.
Retrospective Case Analyses of Two People With Cancer Who Followed the Bill Henderson Protocol
Authors: Page Stacey A. , Bell Laurie Heilman , Mannion Cynthia , Verhoef Marja J. 
Published: August 2013

Objective: To provide a retrospective case analyses of Bill Henderson Protocol adherence, a dietary cancer treatment regimen. Design. Case study analysis based on the National Cancer Institute’s Best Case Series approach. Subjects. Using Mr Henderson’s listserv (N = 31 000), members meeting certain criteria were invited to submit case documentation (diagnostic, treatment, outcome information). Ninety-two people responded. Results: Two people met the Best Case criteria. Both used conventional treatment initially (surgery, radiation, chemotherapy), but later turned exclusively to the Bill Henderson Protocol. Each case perceived benefit. One person eventually passed away. The second has returned to full health. Conclusions: The 2 cases provide a preliminary, detailed description of Bill Henderson Protocol adherence. They do not provide clear evidence of the protocol’s effectiveness but do suggest further research be undertaken to assess the extent to which the Bill Henderson Protocol is followed in real-world settings, including consideration of adherence, side effects, and outcomes.
Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL
Authors: van der Veer Arian , Waanders Esmé , Pieters Rob , Willemse Marieke E. , Van Reijmersdal Simon V. , Russell Lisa J. , Harrison Christine J. , Evans William E. , van der Velden Vincent H. J. , Hoogerbrugge Peter M. , Van Leeuwen Frank , Escherich Gabriele , Horstmann Martin A. , Mohammadi Khankahdani Leila , Rizopoulos Dimitris , De Groot-Kruseman Hester A. , Sonneveld Edwin , Kuiper Roland P. , Den Boer Monique L. 
Published: August 2013

Key Points
BCR-ABL1-like signature and IKZF1 deletions are clinically important to identify high-risk acute lymphoblastic patients.
Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia
Authors: Katzerke Christiane , Madan Vikas , Gerloff Dennis , Bräuer-Hartmann Daniela , Hartmann Jens-Uwe , Wurm Alexander Arthur , Müller-Tidow Carsten , Schnittger Susanne , Tenen Daniel G. , Niederwieser Dietger , Behre Gerhard 
Published: August 2013

Key Points
miR-30c is a direct target of C/EBPα and upregulated by C/EBPα-p42. NOTCH1 is a direct target of miR-30c and regulated by C/EBPα and miR-30c.
Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia
Authors: Goldberg Liat , Tijssen Marloes R. , Birger Yehudit , Hannah Rebecca L. , Kinston Sarah J. , Schütte Judith , Beck Dominik , Knezevic Kathy , Schiby Ginette , Jacob-Hirsch Jasmine , Biran Anat , Kloog Yoel , Marcucci Guido , Bloomfield Clara D. , Aplan Peter D. , Pimanda John E. , Göttgens Berthold , Izraeli Shai 
Published: August 2013

Key PointsERG overexpression in transgenic mice induces a transcriptional leukemia stem cell program characteristic of human AML. PIM1 and RAS are relevant ERG therapeutic targets.
Innate immune control of EBV-infected B cells by invariant natural killer T cells
Authors: Chung Brian K. , Tsai Kevin , Allan Lenka L. , Zheng Dong Jun , Nie Johnny C. , Biggs Catherine M. , Hasan Mohammad R. , Kozak Frederick K. , van den Elzen Peter , Priatel John J. , Tan Rusung 
Published: August 2013

Key PointsB cells rapidly downregulate CD1d expression after EBV infection, thus abrogating iNKT cell recognition. EBV-infected B cells induced to express CD1d elicit iNKT cell functions even in the absence of exogenous antigen.
Aurora and IKK kinases cooperatively interact to protect multiple myeloma cells from Apo2L/TRAIL
Authors: Mazzera Laura , Lombardi Guerino , Abeltino Manuela , Ricca Micaela , Donofrio Gaetano , Giuliani Nicola , Cantoni Anna Maria , Corradi Attilio , Bonati Antonio , Lunghi Paolo 
Published: August 2013

Key Points
Aurora and IKK kinases physically and functionally interact to promote TRAIL resistance in multiple myeloma through NF-κB activation. Pharmacological blockade of Aurora kinases abrogates TRAIL-induced Aurora-IKK kinases interactions and NF-κB activation.
The common hereditary elliptocytosis-associated α-spectrin L260P mutation perturbs erythrocyte membranes by stabilizing spectrin in the closed dimer conformation
Authors: Harper Sandra L. , Sriswasdi Sira , Tang Hsin-Yao , Gaetani Massimiliano , Gallagher Patrick G. , Speicher David W. 
Published: August 2013

Key Points
The common HE mutation αL260P reduces spectrin tetramer links between junctional complexes in red cell membranes by favoring closed dimers. Favoring closed spectrin dimer formation is a new mechanism of red cell membrane destabilization by hereditary anemia mutations.
Pomalidomide
Authors: Lacy Martha Q. , McCurdy Arleigh R. 
Published: August 2013

AbstractThis spotlight review focuses on the second-generation immunomodulatory drug pomalidomide, which was recently approved by the US Food and Drug Administration. This drug was approved for patients with multiple myeloma who have received at least 2 prior therapies, including lenalidomide and bortezomib, and have demonstrated disease progression on or within 60 days of completion of the last therapy. This review focuses on the clinical trial data that led to approval and provides advice for treating physicians who are now prescribing this drug for patients.
Mixed hematopoietic or T-cell chimerism above a minimal threshold restores perforin-dependent immune regulation in perforin-deficient mice
Authors: Terrell Catherine E. , Jordan Michael B. 
Published: August 2013

Key Points
Perforin deficiency causes immune dysregulation and hemophagocytic lymphohistiocytosis, which requires allogeneic HCT for long-term cure. In prf−/− mice, wild-type hematopoietic or CD8+ T-cell engraftment of only 10-20% is sufficient to reestablish normal immune regulation.
Differences in insect resistance between tomato species endemic to the Galapagos Islands
Authors: Lucatti Alejandro F , van Heusden Adriaan W , de Vos Ric CH , Visser Richard GF , Vosman Ben 
Published: August 2013

Abstract

Background
The Galapagos Islands constitute a highly diverse ecosystem and a unique source of variation in the form of endemic species. There are two endemic tomato species, Solanum galapagense and S. cheesmaniae and two introduced tomato species, S. pimpinellifolium and S. lycopersicum. Morphologically the two endemic tomato species of the Galapagos Islands are clearly distinct, but molecular marker analysis showed no clear separation. Tomatoes on the Galapagos are affected by both native and exotic herbivores. Bemisia tabaci is an important introduced insect species that feeds on a wide range of plants. In this article, we address the question whether the differentiation between S. galapagense and S. cheesmaniae may be related to differences in susceptibility towards phloem-feeders and used B. tabaci as a model to evaluate this.

Results
We have characterized 12 accessions of S. galapagense, 22 of S. cheesmaniae, and one of S. lycopersicum as reference for whitefly resistance using no-choice experiments. Whitefly resistance was found in S. galapagense only and was associated with the presence of relatively high levels of acyl sugars and the presence of glandular trichomes of type I and IV. Genetic fingerprinting using 3316 SNP markers did not show a clear differentiation between the two endemic species. Acyl sugar accumulation as well as the climatic and geographical conditions at the collection sites of the accessions did not follow the morphological species boundaries.

Conclusion
Our results suggest that S. galapagense and S. cheesmaniae might be morphotypes rather than two species and that their co-existence is likely the result of selective pressure.
Long-term follow-up of kidney transplant recipients: comparison of hospitalization rates to the general population
Authors: Jiang Ying , Villeneuve Paul J , Schaubel Douglas , Mao Yang , Rao Panduranga , Morrison Howard 
Published: August 2013

Abstract

Background
Kidney transplant recipients are recognized as a vulnerable population that is at increased risk of adverse health outcomes. However, there have been few studies that have compared hospital-related morbidity of these patients to the general population, and how this differs with respect to time since transplantation. Such analyses are useful in estimating the health burden in this patient population.

Methods
We assembled a population-based Canadian cohort (excluding Quebec) of 6,116 kidney transplant recipients who underwent transplantation between 1 April 2001 and 31 December 2008. Record linkage was used to identify hospital discharge records of these patients from 1 April 2001 through 31 March 2009. Hospital discharges were tabulated across the main disease chapters of the ICD10, and person-years of follow-up were calculated across age and sex strata. Comparisons of hospital-related morbidity to the general population were made by using a standardized hospitalization ratio (SHR). For those who underwent transplantation in 2004, stratified analyses were performed to explore differences in hospital discharge rates both before and after transplantation.

Results
After excluding hospitalizations due to complications from transplantation, when compared to the general population, transplant recipients were approximately 6.4 (95% CI: 6.3, 6.5) times more likely to be hospitalized during follow-up. The SHRs were highest during the time periods proximate to transplantation, and then decreased to approximately a five-fold increase from 3 years post transplantation onwards. The largest disease-specific excesses were observed with infectious diseases and diseases of the endocrine system. Among those who underwent transplantation in 2004, the SHR decreased from 11.2 to 5.0 in the periods before and after surgery, respectively.

Conclusions
Our results indicate that, even more than 5-years post transplantation, there remains a more than six-fold difference in hospitalization rates relative to the general population. Additional work is needed to confirm these findings, and to develop strategies to reduce long-term morbidity in this patient population.
Effect of CYP3A4*22, POR*28, and PPARA rs4253728 on Sirolimus In Vitro Metabolism and Trough Concentrations in Kidney Transplant Recipients
Authors: Woillard Jean-Baptiste , Kamar Nassim , Coste Sandra , Rostaing Lionel , Marquet Pierre , Picard Nicolas 
Published: August 2013

BACKGROUNDRecent studies have identified new candidate polymorphisms in the genes related to CYP3A activity or calcineurin inhibitor dose requirements in kidney transplant recipients. These genes and polymorphisms are CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4) (rs35599367-C&gt;T; *22); POR [P450 (cytochrome) oxidoreductase] (rs1057868-C&gt;T; *28); and PPARA (peroxisome proliferator-activated receptor alpha) (rs4253728-G&gt;A). We investigated the impact of these polymorphisms on sirolimus (SRL) in vitro hepatic metabolism, SRL trough concentrations (C0), and SRL adverse events in kidney transplant recipients.METHODSThe clinical study included 113 stable kidney transplant patients switched from a calcineurin inhibitor to SRL (SRL C0 measured at 1, 3, and 6 months thereafter). We investigated SRL metabolism in vitro using human liver microsomes derived from individual donors (n = 31). Microsomes and patients were genotyped by use of Taqman® allelic discrimination assays. The effects of polymorphisms and covariates were studied using multilinear regression imbedded in linear mixed-effect models or logistic regressions.RESULTSIn vitro, the CYP3A4*22 allele resulted in approximately 20% lower metabolic rates of SRL (P = 0.0411). No significant association was found between CYP3A4, CYP3A5, or PPARA genotypes and SRL dose, C0, or C0/dose in kidney transplant patients. POR*28 was associated with a minor but significant decrease in SRL log-transformed C0 [CT/TT vs CC, β = −0.15 (0.05); P = 0.0197] but this did not have any impact on the dose administered, which limited the relevance of the finding. After adjustment for nongenetic covariates and correction for false discovery finding, none of the single-nucleotide polymorphisms tested showed significant association with SRL adverse events.CONCLUSIONSThese recently described polymorphisms do not seem to substantially influence the pharmacokinetics of SRL or the occurrence of SRL adverse events in kidney transplant recipients.
Teaching art with artworks: Pre-service primary teachers’ aesthetic preferences
Authors: Pavlou Victoria 
Published: August 2013

Abstract
In many countries, generalist teachers and not art specialists teach art in primary education. This article examines the range of pre-service primary school teachers’ aesthetic preference and explores what kind of artworks they would most likely choose for organizing learning activities for children, as well as reasons that influence their choices. The kind of artworks they choose will likely have an effect on their pupils’ understandings of art. A mixed methodology research study was carried out with 91 pre-service primary school teachers in Cyprus. The data indicate that the participants had a rather limited understanding of art and reflected a narrow range of ideas and values. Although many participants did not perform non-reflective judgments about artworks, their strong attraction to colours and notions of realism entwine with expression implied that popular culture ideas and modernism ideas about art would be largely reflected in their teaching, thus denying children with encounters with other forms of art.
John Blackburn: Without reference
Authors: Moser Shelby 
Published: August 2013

Abstract
John Blackburn is a contemporary artist from the original mid-twentieth-century British painters. Once expected to be amongst the top artists of the 1960s, a family crisis caused him to put aside a career as an artist. He continued to paint in his solitary studio, only to be rediscovered in 2005. His repertoire of paintings expand over the last four decades but are only now being fully appreciated. With recent exhibitions in London and a growing list of collectors, Blackburn has caught the attention of modernist connoisseurs who have the rare experience of viewing his works without the tradition of influence or criticism.
Reviews
Authors: Kantawala Ami , Moser Shelby 
Published: August 2013

Abstract
Naea 2013 Conference Review, Fort Worth, Texas
Art & Pornography, Philosophical Essays, Hans Maes and Jerrold Levinson (eds) (2012) oxford: Oxford University Press, Isbn 978-0-19-960958-1, Hardback, £35.00, 344 pages.