bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Base‐Promoted Cyclization of 3‐Alkynylquinoxaline‐2‐carbonitriles with CH‐Acids: A New Method for the Phenazine Ring Synthesis.
Authors: Nguyen Huong T. L. , Gulevskaya Anna V. , Pozharskii Alexander F. , Nelina‐Nemtseva Julia I. 
Published: November 2014

AbstractThe formation of the red‐colored 2,3‐disubstituted phenazin‐1‐amine derivatives is possible under mild conditions and the substituents at position 2 allow a further modification of the heterocyclic system.
ChemInform Abstract: Synthesis of Novel Pyrazolo[3,4‐d][1,2,3]triazines.
Authors: Gurenko A. O. , Khutova B. M. , Klyuchko S. V. , Vasilenko A. N. , Brovarets V. S. 
Published: November 2014

AbstractReactions of pyrazolo[3,4‐d][1,2,3]triazin‐4‐one (I) with alkylating agents, formaldehyde or formaldehyde in presence of secondary amines proceed with the retention of the bicyclic structure.
ChemInform Abstract: Microwave‐Mediated InCl3‐Catalyzed Three‐Component Anellation of Thiadiazine Ring onto 4‐Amino‐4H‐[1,2,4]triazole‐3‐thiol.
Authors: Srivastava V. , Singh P. K. , Singh P. P. 
Published: November 2014

AbstractAn environmentally benign, one‐pot cyclization procedure for the synthesis of 3,6‐diaryl[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazines (IV) (12 examples) is described.
ChemInform Abstract: One‐Step Synthesis of Nitrogen‐Containing Medium‐Sized Rings via α‐Imino Diazo Intermediates.
Authors: Medina Florian , Besnard Celine , Lacour Jerome 
Published: November 2014

AbstractThe transformation of the 4‐butyl or 4‐tert‐butyl substituted analogues of triazole (I) leads to no or trace amounts of the corresponding dioxazocines due to formation of ring‐opened products resulting from alkyl and hydride shifts.
ChemInform Abstract: Simple Base‐Free Miyaura‐Type Borylation of Triarylantimony Diacetates with Tetra(alkoxo)diborons under Aerobic Conditions.
Authors: Yasuike Shuji , Dong Yuqiang , Kakusawa Naoki , Matsumura Mio , Kurita Jyoji 
Published: November 2014

AbstractIt is demonstrated, that triarylantimony diacetates are efficient reagents for the Pd‐catalyzed coupling with standard diboron compounds to form arylboronic esters in good to moderate yields.
ChemInform Abstract: Rhodium‐Catalyzed B—H Activation of 1,2‐Azaborines: Synthesis and Characterization of BN Isosteres of Stilbenes.
Authors: Brown Alec N. , Zakharov Lev N. , Mikulas Tanya , Dixon David A. , Liu Shih‐Yuan 
Published: November 2014

AbstractCompound (IIIb) represents an isostere of the biologically active 4‐methoxy‐E‐stilbene, which is further explored by X‐ray analysis, investigation of its photophysical properties and solvatochroism studies.
ChemInform Abstract: Synthesis of π‐Extended Dibenzophospholes by Intramolecular Radical Cyclization and Their Properties.
Authors: Furukawa Shunsuke , Haga Shunsuke , Kobayashi Junji , Kawashima Takayuki 
Published: November 2014

AbstractThe structures of products (VI) and (VII) are examined by X‐ray analysis.
ChemInform Abstract: Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum.
Authors: Yin Xia , Feng Tao , Shang Jian‐Hua , Zhao Yun‐Li , Wang Fang , Li Zheng‐Hui , Dong Ze‐Jun , Luo Xiao‐Dong , Liu Ji‐Kai 
Published: November 2014

AbstractFifteen new triterpenoids, including terreolides A‐C (I) possessing a unique trioxaspiroketal system and terreolides D‐F (II) having an unprecedented carbon skeleton, are isolated from the title mushroom.
ChemInform Abstract: Diterpenes and Sesquiterpenes with anti‐Coxsackie Virus B3 Activity from the Stems of Illicium jiadifengpi.
Authors: Yu Shi‐Shan , et al. et al. 
Published: November 2014

AbstractSeven new diterpenes (I)‐(VII) (jiadifenoic acids J‐P) and two new sesquiterpenes (VIII) and (IX) (sesquicaranoic acids A and B) as well as four known compounds are isolated from them title species.
ChemInform Abstract: Novel Nardosinane Type Sesquiterpenoids from Nardostachys chinensis Batal.
Authors: Zhang Jin‐Bo , Liu Ming‐Li , Duan Ying‐Hui , Tian Hai‐Yan , Li Chang , Dai Yi , Yao Xin‐Sheng 
Published: November 2014

AbstractFive new sesquiterpenoids (I)‐(V) (nardosinanone A‐E) are isolated from the title species.
ChemInform Abstract: Ethyl 2‐Cyano‐2‐(2‐nitrobenzenesulfonyloxyimino)acetate (o‐NosylOXY): A Recyclable Coupling Reagent for Racemization‐Free Synthesis of Peptide, Amide, Hydroxamate, and Ester.
Authors: Dev Dharm , Palakurthy Nani Babu , Thalluri Kishore , Chandra Jyoti , Mandal Bhubaneswar 
Published: November 2014

AbstractThe title agent is stable at room temperature for a long period.
ChemInform Abstract: Enantiodivergent Syntheses of (‐)‐ and (+)‐Dysibetaine CPa and N‐Desmethyl Analogue.
Authors: Sakai Michihiro , Tanaka Kento , Takamizawa Satoshi , Oikawa Masato 
Published: November 2014

AbstractThe total syntheses of (‐)‐(I), isolated from Lendenfeldia chondrodes, and its antipode render possible the unambiguous determination of the absolute configuration.
ChemInform Abstract: A New Flavonol Glycoside from the Root of Sida rhombifolia.
Authors: Harikant Harikant , Bhadauria Vivek , Maurya Priyanka , Singh Pravin K. , Singh J. 
Published: November 2014

AbstractNew flavonol glycoside (I) is isolated and characterized by chemical, spectral and elemental analysis.
ChemInform Abstract: New Methods for the Synthesis of Carotenoid Glycosides.
Authors: Hanaura Miki , Agocs Attila , Boeddi Katalin , Deli Jozsef , Nagy Veronika 
Published: November 2014

AbstractCompound (Ia) is obtained by using the acetimidate method and compound (Ib) by using the Ferrier rearrangement.
ChemInform Abstract: New Water Soluble Pd‐Imidate Complexes as Highly Efficient Catalysts for the Synthesis of C5‐Arylated Pyrimidine Nucleosides.
Authors: Kapdi Anant , Gayakhe Vijay , Sanghvi Yogesh S. , Garcia Joaquin , Lozano Pedro , da Silva Ivan , Perez Jose , Serrano J. Luis 
Published: November 2014

AbstractFour new water soluble Pd(II) complexes are synthesized and characterized.
ChemInform Abstract: Syntheses of Nucleosides with 2′‐Spirolactam and 2′‐Spiropyrrolidine Moieties as Potential Inhibitors of Hepatitis C Virus NS5B Polymerase.
Authors: Dang Qun , Zhang Zhibo , Tang Bingyu , Song Yang , Wu Ling , Chen Tongqian , Bogen Stephane , Girijavallabhan Vinay , Olsen David B. , Meinke Peter T. 
Published: November 2014

AbstractThe synthesis of nucleosides with 2‐spirolactam (III) and 2‐spiropyrrolidine (IV) moiety is based on the key intermediate (II) which is obtained through epoxide ring opening.
ChemInform Abstract: Serendipitous Discovery of a Cascade Approach to Perhydrodibenzofuranones Related to the Natural Product Incarviditone.
Authors: Christou Stephania , Edwards Alyn C. , Pritchard Robin G. , Quayle Peter , Stratford Ian J. , Whitehead Roger C. 
Published: November 2014

AbstractThe toxicity of the novel dimers (I) towards the Non‐Small‐Cell Lung Cancer Line A548 is assessed in view of the discovery of antiproliferative agents.
ChemInform Abstract: Stereoselective Formation of Tetrahydrofuran Rings via [3 + 2] Annulation: Total Synthesis of Plakortone L.
Authors: Sugimura Hideyuki , Sato Shougo , Tokudome Kensei , Yamada Takeshi 
Published: November 2014

AbstractThe key step can be used for a general stereoselective approach to the structural motif of the Plakortone family.
ChemInform Abstract: Highly Efficient Removal of 137Cs in Seawater by Potassium Titanium Ferrocyanide Functionalized Magnetic Microspheres with Multilayer Core—Shell Structure.
Authors: Yi Rong , Ye Gang , Wu Fengcheng , Wen Mingfen , Feng Xiaogui , Chen Jing 
Published: November 2014

AbstractFe3O4@SiO2@KTiFC (KTiFC: potassium titanium ferrocyanide) particles are prepared from mixtures of Fe3O4@SiO2 in H2O, hydroxypropyl cellulose, and Ti(OBu)4 in EtOH (reflux, 85°C, 150 min), followed by soaking the obtained product in a HCl solution of K4Fe(CN)6 (stirring for 5 h).
ChemInform Abstract: Xanthones from Swertia mussotiias Multitarget‐Directed Antidiabetic Agents.
Authors: Zheng Huan‐Huan , Luo Cui‐Ting , Chen Heru , Lin Juan‐Na , Ye Chun‐Ling , Mao Shuang‐Shuang , Li Yu‐Lin 
Published: November 2014

AbstractThe screening of known xanthones from Swertia mussotii as potential multitarget antidiabetic agents is described.
ChemInform Abstract: Synthesis of Five‐ and Six‐Membered Cyclic Organic Peroxides: Key Transformations into Peroxide Ring‐Retaining Products
Authors: Terent'ev Alexander O. , Borisov Dmitry A. , Vil Vera A. , Dembitsky Valery M. 
Published: November 2014

AbstractReview: 443 refs.
ChemInform Abstract: Production of Pyrans, Pyridazines, Pyrimidines, Pyrazines and Triazine Compounds Using Benzoylacetonitriles as a Precursor
Authors: Abdel‐Wahab Bakr F. , El‐Mansy Mohamed F. , Khidre Rizk E. 
Published: November 2014

AbstractReview: 85 refs.
Bromolactamization: Key Step in the Stereoselective Synthesis of Enantiomerically Pure, cis‐Configured Perhydropyrroloquinoxalines
Authors: Schulte Adrian , Situ Xingci , Saito Susumu , Wünsch Bernhard 
Published: November 2014

ABSTRACTCompounds based on the pyrroloquinoxaline system can interact with serotonin 5‐HT3, cannabinoid CB1, and μ‐opioid receptors. Herein, a chiral pool synthesis of diastereomerically and enantiomerically pure bromolactam (S,R,R,R)‐14A is presented. Introduction of the cyclohexenyl ring at the N‐atom of (S)‐proline derivatives 8 or methyl (S)‐pyroglutamate (12) led to the N‐cyclohexenyl substituted pyrrolidine derivatives 4 and 13, respectively. All attempts to cyclize the (S)‐proline derivatives 4 with a basic pyrrolidine N‐atom via [3 + 2] cycloaddition, aziridination, or bromolactamization failed. Fast aromatization occurred during treatment of cyclohexenamines under halolactamization conditions. In contrast, reaction of a 1:1 mixture of diastereomeric pyroglutamates (S,R)‐13bA and (S,S)‐13bB with LiOtBu and NBS provided the tricyclic bromolactam (S,R,R,R)‐14A with high diastereoselectivity from (S,R)‐13bA, but did not transform the diastereomer (S,S)‐13bB. The different behavior of the diastereomeric pyroglutamates (S,R)‐13bA and (S,S)‐13bB is explained by different energetically favored conformations. Chirality 26:793–800, 2014. © 2014 Wiley Periodicals, Inc.
First‐Principle Results for the Radial Pair Distribution Function in Strongly Coupled One‐Component Plasmas
Authors: Ott T. , Bonitz M. 
Published: November 2014

AbstractThe radial pair distribution function (RPDF) is the most simple way to characterize the structure of a system. In this work, we provide a comprehensive overview of the dependence of the RPDF on the coupling parameter and screening length in Coulomb and Yukawa One‐Component plasmas. These data allows for a precise assessment of the coupling strength of experiments and simulations via a structural measurement and give a benchmark for analytical models. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Toward a Nonequilibrium Green Functions Approach to Diffusion in Strongly Coupled Finite Quantum Systems
Authors: Bonitz M. , Schlünzen N. , Hermanns S. 
Published: November 2014

AbstractTransport properties of strongly correlated quantum systems are of central interest in condensed matter, ultracold atoms and in dense plasmas. There, the proper treatment of strong correlations poses a great challenge to theory. Here, we apply a Nonequilibrium Green Functions approach using a lattice model as a basic system. This allow us to treat a finite spatially inhomogeneous system with an arbitrary nonequilibrium initial state. Placing all particles initially to one side of the system allows for a nonequilibrium study of diffusion. Strong correlation effects are incorporated via T‐matrix selfenergies. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Utilility of flow cytometry as ancillary study to improve the cytologic diagnosis of thyroid lymphomas
Authors: Stacchini Alessandra , Pacchioni Donatella , Demurtas Anna , Aliberti Sabrina , Cassenti Adele , Isolato Giuseppe , Gazzera Carlo , Veltri Andrea , Sapino Anna , Papotti Mauro , Freddi Milena , Palestini Nicola , Sisto Gabriella , Novero Domenico 
Published: November 2014

BackgroundTo evaluate the efficacy of the use of flow cytometry (FC) immunophenotyping together with fine‐needle aspiration cytology (FNAC) in the diagnosis of thyroid lymphoma.MethodsFC was performed in parallel with FNAC in 35 samples of suspected thyroid lymphoma over a 12 years period. Results were correlated with histological or molecular findings and follow‐up, when available.ResultsA final diagnosis of lymphoma was given in 13 of 35 (37.1%) specimens. Among the 22 cases considered negative for lymphoma by FC, 11 were diagnosed as thyroiditis by cytology, 7 as reactive, 2 were anaplastic carcinoma, and 2 cases were considered cytologically suspicious for lymphoma but were not confirmed by further investigations. Histology on core biopsy or molecular analysis was available in 12 of 13 lymphoma cases (92.3%). Data obtained by the combination cytology/FC were confirmed in all cases on histology biopsies. Correlation with histology showed a sensitivity and a specificity of 100% for the combination cytology/FC.ConclusionsFC is an important additional test that can contribute with cytology to the identification of lymphomas of the thyroid. FC can detect the presence of small neoplastic lymphocyte populations and may contribute to the diagnosis of cases in which the lymphoid infiltrate is difficult to interpret on cytology alone. © 2014 International Clinical Cytometry Society
Is thyroid gland only a “land” for primary malignancies? role of morphology and immunocytochemistry
Authors: Rossi Esther Diana , Martini Maurizio , Straccia Patrizia , Gerhard Rene , Evangelista Antonella , Pontecorvi Alfredo , Fadda Guido , Maria Larocca Luigi , Schmitt Fernando 
Published: November 2014

BackgroundThyroid Metastases (TM) represent a rare entity with an estimated variability ranging between 0 and 24%. Fine needle aspiration cytology (FNAC) might be useful in discriminating between primary and TM nodules especially when ancillary techniques (i.e., immunocytochemistry‐ICC) are carried out.MethodsWe herein appraised a series of 20 TM on FNAC analyzed between 2000 and 2013. We included eight male and 12 female patients. The cytological cases were processed with both liquid based (LBC) and conventional cytology.ResultsWe reported 2.2% TM out of 910 malignancies. Our TM cases resulted as: six lung (LG), five gastro‐intestinal (GI), five breast (B), three larynx (LX), and one clear cell renal carcinoma (CCRC) metastases. All the patients had a previous known cancer history. Although the cytological features were likely to suspect a TM, the application of ICC panels was contributive in 100% cases. None of TMs resulted as a unique localization whereby two cases underwent total thyroidectomy (including one B and one CCRC) and 18 TM were treated with radio‐chemotherapy approaches.ConclusionsFNAC empowered the diagnostic workup of patients with TM avoiding useless surgical approach. The low sensitivity of cytology might be reinforced by the application of ancillary techniques. In contrast with the reported predominant rate of kidney metastatic carcinomas, our findings underlined that intestinal cancer as well as lung and breast are the most common TM. TM are frequently multifocal and in a contest of a systemic disease so that a tailored therapy seems to be the best treatment Diagn. Cytopathol. 2015;43:374–380. © 2014 Wiley Periodicals, Inc.
Understanding the Dynamics of Eu3+ Ions in Room‐Temperature Ionic Liquids – Electrochemical and Time‐Resolved Fluorescence Spectroscopy Studies
Authors: Gupta Ruma , Gupta Santosh K. , Gamre J. S. , Lohithakshan K. V. , Natarajan V. , Aggarwal S. K. 
Published: November 2014

AbstractTo understand the oxidation state, coordination geometry, and physicochemical behavior of the Eu3+ complex with dihexyl N,N‐diethylcarbamoylmethylphosphonate (DHDECMP) in the ionic liquid (IL) 1‐butyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)imide ([bmim][NTf2]), the spectroscopic and electrochemical properties of the system were investigated. The electrochemical behavior of Eu3+–DHDECMP in [bmim][NTf2] was studied by cyclic voltammetry (CV) and chronoamperometry at a glassy carbon (GC) electrode. The reduction of Eu3+ to Eu2+ in [bmim][NTf2] is quasireversible and controlled by diffusion as well as charge‐transfer kinetics. Photoluminescence spectroscopy confirms that the symmetry around the europium ions in Eu3+–DHDECMP in the room‐temperature IL (RTIL) is relatively low; this is further supported by calculations of the Judd–Ofelt parameters (Ω2 higher than Ω4). On the basis of fluorescence lifetime measurements, the number of water molecules in the inner sphere is six for uncomplexed europium ions, and practically no water molecules are retained in the presence of the complexing extractant DHDECMP.
The Synthesis, Structure, and Electrical Characterization of (SnSe)1.2TiSe2
Authors: Merrill Devin R. , Moore Daniel B. , Ditto Jeffrey , Sutherland Duncan R. , Falmbigl Matthias , Winkler Markus , Pernau Hans‐Fridtjof , Johnson David C. 
Published: November 2014

Abstract(SnSe)1.2TiSe2 was found to self‐assemble from a precursor containing modulated layers of Sn–Se and Ti–Se over a surprisingly large range of layer thicknesses and compositions. The constituent lattices form an alternating layer superstructure with rotational disorder present between the layers. This compound was found to have the highest Seebeck coefficient measured for analogous TiX2 containing misfit layered compounds to date, suggesting potential for low‐temperature thermoelectric applications. Electrical characterization suggests that electrons transferred from SnSe to TiSe2 are responsible for the higher carrier concentration observed relative to bulk TiSe2. The transfer of charge from one constituent to the other may provide a mechanism for doping layered dichalcogenides for various applications without negatively affecting carrier mobility.
Substitutional Lability of Diphosphine Ligands in Tetrahedral Iron(II) Chloro Complexes
Authors: Langer Robert , Bönisch Friedrich , Maser Leon , Pietzonka Clemens , Vondung Lisa , Zimmermann Thomas Philipp 
Published: November 2014

AbstractA series of iron(II) dihalogenide complexes with two different bisphosphinoethane ligands is reported. In the case of 1,2‐bis(diphenylphosphanyl)ethane (dppe), depending on the stoichiometry, the tetrahedral [(μ‐dppe)FeCl2]n and octahedral trans‐[(dppe)2FeCl2] complexes are formed. The polymeric complex [(μ‐dppe)FeCl2]n, with iron in a tetrahedral environment, preferentially reacts with chelating amines to give the octahedral diphosphine complex, trans‐[(dppe)2FeCl2], and different octahedral amine complexes. With the sterically more demanding 1,2‐bis(diisopropylphosphanyl)ethane (dippe), the monomeric and tetrahedral halogen complexes [(dippe)FeX2] are exclusively obtained (X = Cl, Br). These complexes react with chelating amines in a similar manner, to give free ligand and the corresponding octahedral amine complex. The present results suggest that the diphosphines in the investigated iron(II) complexes are bound too weakly to form productive catalyst precursors.
Omega‐3 fatty acid supplementation candidates can be selected using fatty acid profiling
Authors: Galuszka Jan , Vostalova Jitka , Cervena Blanka , Galuszkova Dana , Simanek Vilim , Holcapek Michal , Cifkova Eva , Lisa Miroslav , Vrbkova Jana , Bancirova Martina , Taborsky Milos , Novotny Dalibor 
Published: November 2014

The aim of this study was to evaluate the fatty acid (FA) profile in the plasma and erythrocyte membranes of apparently healthy men compared to male patients with various cardiovascular diseases (CVD). The plasma FA profiles were analyzed in five groups of subjects aged 37–57 years: groups 1 and 2 were male voluntary blood donors with a body mass index (BMI) 25.1 ± 1.6, (Group 1, N = 12) and a BMI 32.9 ± 4.5, (Group 2, N = 11) respectively, male patients with chronic heart failure due to dilated cardiomyopathy (Group 3, N = 10), chronic atrial fibrillation without heart failure or coronary heart disease (Group 4, N = 10) and patients after myocardial infarction (Group 5, N = 11). The FA profile in plasma and erythrocytes was measured by gas chromatography (GC) with flame ionization detection and basic plasma lipid parameters were then estimated. Deficiencies of eicosapentaenoic acid and docosahexaenoic acid were found in all the groups of CVD patients and in Group 2 (BMI 32.9 ± 4.5) of this Central European population. Unfavorable alterations in FA composition and clinical biochemistry parameters were found in patients with dilated cardiomyopathy (Group 3). Further, 75% of Group 1 (blood donors) had an average plasma PUFA level in the worst quartile for relative risk of cardiovascular events. Tailored n‐3 PUFA supplementation should be recommended not only for secondary prevention in patients suffering from CVD but also for primary prevention in overweight and obese persons with a proven deficiency.Practical applications: Plasma and erythrocyte membrane n‐3 polyunsaturated fatty acid (PUFA) levels are an important parameter of diet composition as well as a marker of cardiovascular risk. Regular sea fish intake or alternative supplementation with the n‐3 PUFA recommendation is in all probability insufficiently realized, particularly in inland countries. In addition to contemporary guidelines and practice, research is providing data on the use of FA analysis for revealing people with an n‐3 PUFA deficiency. This approach could benefit people suffering from CVD as well as for overweight and obese populations with demonstrated deficiency.Tailored n‐3 PUFA supplementation should be recommended not only for secondary prevention in patients suffering from CVD but also for primary prevention in overweight and obese persons with a proven deficiency.
Formulation and preparation of a stable intravenous disulfiram‐loaded lipid emulsion
Authors: Chen Xi , Zhang Ling , Hu Xi , Lin Xia , Zhang Yu , Tang Xing 
Published: November 2014

In this study, a disulfiram‐loaded lipid emulsion (DSF‐LE) was prepared to improve its clinical application in cancer treatment. DSF‐LEs were characterized with regard to their visual appearance, particle size distribution, pH values, and percentage drug degradation. However, it was found that DSF‐LEs had poor chemical stability, which might have been affected by the pH values and lecithin used in our previous study. Buffer salts and CO2 were used respectively to control the pH, and a significant reduction in DSF degradation in the acceleration test was observed when CO2 was used as a protective gas. Investigations of naturally‐extracted and synthetic lecithins showed that lecithin contained more phosphatidylethanolamine (PE), causing more degradation of DSF due to its higher peroxidation. As far as the degradation mechanism was concerned, it was speculated that free radicals generated during the peroxidation process of unsaturated acyl‐groups of lecithin could react with DSF to produce unstable diethyldithiocarbamic acid (DDC), which readily broke down into CS2 and diethylamine. Diethylamine is an alkaline compound that can increase the pH of DSF‐LEs, leading to the further degradation of DSF. Finally, an optimum DSF‐LE was obtained with good stability after being accelerated at 60°C for 5 days and at 25°C for 3 months.Practical applications: DSF is extremely unstable in gastric juice and blood, so the currently available oral formulation of DSF has limited its clinical application. Here we propose a DSF‐LE to increase the therapeutic amount of drug reaching the cancer to improve its application in cancer treatment. In addition, some influences of formulation were investigated in detail. The investigation of pH control and properties of lecithins might have some guiding significances for industrial manufacture.In this article, a stable intravenous disulfiram‐loaded lipid emulsion was developed. The influences of pH values, oil, and lecithin on the stability of drug in emulsion were researched to obtain an optimum formulation. In the end, a probable interaction of DSF with lecithin was given according to a series of investigations of naturally‐extracted and synthetic lecithins.