bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding modifiable caregiver factors contributing to child development among young children in rural Malawi
Authors: Bliznashka Lilia , Nwabuikwu Odiche , Ahun Marilyn , Becker Karoline , Nnensa Theresa , Roschnik Natalie , Kachinjika Monice , Mvula Peter , Munthali Alister , Ndolo Victoria , Katundu Mangani , Maleta Kenneth , Quisumbing Agnes , Gladstone Melissa , Gelli Aulo 
Published: July 2024

AbstractThis study examined modifiable caregiver factors influencing child development in Malawi using baseline data from 1,021 mothers and their children <2 years of age participating in a cluster‐randomized controlled trial implemented in rural Malawi (2022–2025). We fit an evidence‐based theoretical model using structural equation modelling examining four caregiver factors: (1) diet diversity (sum of food groups consumed in the past 24 h), (2) empowerment (assessed using the project‐level Women's Empowerment in Agriculture Index), (3) mental health (assessed using the Self‐Reported Questionnaire, SRQ‐20), and (4) stimulation (number of stimulation activities the mother engaged in the past 3 days). Child development was assessed using the Malawi Development Assessment Tool (norm‐referenced aggregate Z‐score). The model controlled for child, caregiver, and household socioeconomic characteristics. Results showed that caregiver dietary diversity was directly associated with higher child development scores (standardized coefficient 0.091 [95% CI 0.027, 0.153]) and lower SRQ‐20 scores −0.058 (−0.111, −0.006). Empowerment was directly associated with higher child development scores (0.071 [0.007, 0.133]), higher stimulation score (0.074 [0.013, 0.140]), higher dietary diversity (0.085 [0.016, 0.145]), and lower SRQ‐20 scores (−0.068 [−0.137, −0.002]). Further, higher empowerment was indirectly associated with improved child development through enhancement of caregiver dietary diversity, with an indirect effect of 0.008 (0.002, 0.018). These findings highlight the important role that caregiver diet and empowerment play in directly influencing child development and other aspects of caregiver well‐being. Interventions aimed at enhancing child development should consider these factors as potential targets to improve outcomes for children and caregivers.
Interpreting the role of antioxidants in vivo: A cautionary tale
Authors: Downs Diana M. , Poole Robert K. 
Published: July 2024

AbstractBacteria have a remarkable ability to sense environmental stresses and to respond to these stressors by adapting their metabolism and physiology. In recent publications, investigators have suggested that multiple stresses that cause cell death share the mechanistic feature of stimulating the formation of reactive oxygen species (ROS). A central piece of evidence cited in these claims is the ability of exogenous antioxidant compounds to mitigate stress‐related cell death. The validity of attributing a positive effect of exogenous antioxidants to ROS‐mediated stress is challenged by an important study by Korshunov and Imlay in this issue of Molecular Microbiology. This study reports biochemical data that convincingly show that some commonly used antioxidants quench oxidants orders of magnitude too slowly to have a significant effect on the concentration of ROS in the cell. Under conditions where antioxidants minimize cell death, they also slow growth. Significantly, slowing cell growth by other means has the same restorative effect as adding an antioxidant. Based on the solid biochemical and genetic data, Korshunov and Imlay make the case for discarding the use of antioxidants to diagnose conditions that generate increased internal ROS production.
Mothers' experiences of privacy in neonatal intensive care units: A qualitative study
Authors: Maleki Maryam , Abbasi Soheila , Esmaeili Maryam , Mardani Abbas 
Published: July 2024

AbstractBackgroundExamining the privacy experiences of mothers in neonatal intensive care units (NICUs) can play a crucial role in bolstering patient privacy safeguards and elevating the overall quality of health care. However, our understanding of mothers' experiences regarding privacy issues they may face after their infants' hospitalization in the NICU is limited.AimThis study aimed to investigate the experiences of mothers concerning privacy within NICUs to contribute valuable insights for improving infant care and privacy protection.DesignA qualitative content analysis using a conventional approach was conducted. A total of 18 participants, with diverse sociodemographic backgrounds, were interviewed using open‐ended questions. Qualitative content analysis was undertaken for data analysis.SettingThe study was conducted in the NICU of an urban teaching hospital in Iran.ResultsThe study identified four main themes: ‘understanding of privacy’, ‘fluctuating respect for privacy’, ‘efforts to maintain privacy’ and ‘privacy barriers’. Participants viewed privacy as multidimensional, influenced by cultural and religious factors. Respect for privacy varied, with instances of both adherence and violation. Mothers employed strategies to preserve privacy, emphasizing the importance of their infants' privacy. Privacy barriers included hospital attire, the physical space of the NICU, inhomogeneous human resources and insufficient supervision and training.ConclusionThis study, the first of its kind in the NICU context, provides valuable insights into maternal experiences of privacy. Integrating these insights into practice and future research can contribute to creating more empathetic and privacy‐respecting NICU environments.Relevance to Clinical PracticeHealth care providers can use these findings to enhance support for mothers, potentially reshaping physical spaces and communication practices within NICUs.
Effect of feathers on drag in plunge‐diving birds
Authors: Debenedetti Florent , Jung Sunghwan 
Published: July 2024

AbstractThis study explores the impact of feathers on the hydrodynamic drag experienced by diving birds, which is critical to their foraging efficiency and survival. Employing a novel experimental approach, we analyzed the kinematics of both feathered and nonfeathered projectiles during their transition from air to water using high‐speed imaging and an onboard accelerometer. The drag coefficients were determined through two methods: a direct calculation from the acceleration data and a theoretical approach fitted to the observed velocity profiles. Our results indicate that feathers significantly increase the drag force during water entry, with feathered projectiles exhibiting approximately double the drag coefficient of their smooth counterparts. These findings provide new insights into the role of avian feather morphology in diving mechanics and have potential implications for the design of bioinspired aquatic vehicles in engineering. The study also discusses the biological implications of increased drag due to feathers and suggests that factors such as body shape might play a more critical role in the diving capabilities of birds than previously understood.
Validation of Artificial Intelligence in the Classification of Adolescent Idiopathic Scoliosis and the Compairment to Clinical Manual Handling
Authors: Tingsheng Lu , Chunshan Luo , Shudan Yao , Xingwei Pu , Qiling Chen , Minglu Yang , Lu Chen , Lihang Wang 
Published: July 2024

ObjectiveThe accurate measurement of Cobb angles is crucial for the effective clinical management of patients with adolescent idiopathic scoliosis (AIS). The Lenke classification system plays a pivotal role in determining the appropriate fusion levels for treatment planning. However, the presence of interobserver variability and time‐intensive procedures presents challenges for clinicians. The purpose of this study is to compare the measurement accuracy of our developed artificial intelligence measurement system for Cobb angles and Lenke classification in AIS patients with manual measurements to validate its feasibility.MethodsAn artificial intelligence (AI) system measured the Cobb angle of AIS patients using convolutional neural networks, which identified the vertebral boundaries and sequences, recognized the upper and lower end vertebras, and estimated the Cobb angles of the proximal thoracic, main thoracic, and thoracolumbar/lumbar curves sequentially. Accordingly, the Lenke classifications of scoliosis were divided by oscillogram and defined by the AI system. Furthermore, a man–machine comparison (n = 300) was conducted for senior spine surgeons (n = 2), junior spine surgeons (n = 2), and the AI system for the image measurements of proximal thoracic (PT), main thoracic (MT), thoracolumbar/lumbar (TL/L), thoracic sagittal profile T5–T12, bending views PT, bending views MT, bending views TL/L, the Lenke classification system, the lumbar modifier, and sagittal thoracic alignment.ResultsIn the AI system, the calculation time for each patient's data was 0.2 s, while the measurement time for each surgeon was 23.6 min. The AI system showed high accuracy in the recognition of the Lenke classification and had high reliability compared to senior doctors (ICC 0.962).ConclusionThe AI system has high reliability for the Lenke classification and is a potential auxiliary tool for spinal surgeons.
Efficacy Analysis of Arthroscopic Surgery Combined with Intra‐articular Chitosan Injection for Stage II‐III Knee Osteoarthritis in Patients with Abnormal Body Weight
Authors: Su Qihang , Cai Qiuchen , Feng Xiaofei , Huang Chenglong , Ge Heng'an , Chen Liyang , Xue Chao , Liu Centao , Li Jun , Cheng Biao 
Published: July 2024

ObjectiveWeight is an influential factor in knee osteoarthritis (KOA). However, the effect of abnormal body weight on chitosan's efficacy in treating KOA is unclear. This study aimed to explore the differences in the effectiveness of arthroscopic surgery combined with intra‐articular chitosan injection for KOA in patients with abnormal body weight.MethodsPatients with stage II‐III KOA (Kellgren–Lawrence rating, K‐L) undergoing arthroscopic surgery were recruited for this clinical study from January 2020 to September 2021. Based on body mass index (BMI) and intra‐articular chitosan injection, patients with KOA undergoing arthroscopic surgery (138 patients) were divided into four groups: low‐weight‐non‐injection (Lw‐N, BMI <18.5); low‐weight‐chitosan injection (Lw‐CS, BMI <18.5); overweight‐non‐injection (Ow‐N, BMI ≥25); overweight‐chitosan injection (Ow‐CS, BMI ≥25). A 2‐year follow‐up was conducted to evaluate various indicators, including the visual analogue scale (VAS) and the Western Ontario and McMaster Universities osteoarthritis index score (WOMAC). Statistical analyses were performed using relevant parametric or non‐parametric tests.ResultsIn total, 138 patients with KOA were included in this study. There were no significant differences in gender, age, and incidence of chronic residual pain after arthroscopy among the four groups (p > 0.05). The proportion of patients undergoing subsequent knee arthroplasty during the 2‐year follow‐up period was significantly higher in the Ow‐CS group (20/35) than in the Lw‐CS group (12/39) (p < 0.05). The K‐L rating showed an overall increasing trend over time, with the K‐L rating in the Ow‐N and Ow‐CS groups significantly higher than that in the Lw‐CS group at the final follow‐up (p < 0.05). VAS and WOMAC scores significantly decreased at 1 and 3 months post‐arthroscopy and then increased. One month after arthroscopy, VAS was significantly lower (p < 0.05) in the intra‐articular chitosan injection groups (Lw‐CS and Ow‐CS) compared with the non‐injection groups (Lw‐N and Ow‐N). VAS was lower in the Ow‐CS group than in the Lw‐CS group (p < 0.05). There was no significant difference in WOMAC between the intra‐articular chitosan injection and non‐injection groups at each time point (Lw‐N vs. Lw‐CS, Ow‐N vs. Ow‐CS, p > 0.05).ConclusionArthroscopic surgery combined with intra‐articular chitosan injection shows short‐term positive effects in treating KOA. Intra‐articular chitosan injection appears to have a greater short‐term pain relief effect in obese patients.
Dupilumab for the treatment of alopecia areata in pediatric patients with atopic dermatitis: A scoping review
Authors: Metko Dea , Mehta Shanti , Sibbald Cathryn 
Published: July 2024

AbstractOur study aims to synthesize existing evidence of dupilumab for alopecia areata (AA) in pediatric patients with atopic dermatitis (AD). We searched MEDLINE and Embase on March 1, 2024, using keywords related to AD, AA, dupilumab, and pediatric patient populations per PRISMA‐ScR guidelines. A mean SALT score reduction of 42.6 following dupilumab treatment (p < .01) over an average of 3.21 months, and a mean reduction of Investigator Global Assessment (IGA) levels of 2.14 units (p < .01) demonstrates the efficacy of dupilumab in pediatric AA when there is concurrent AD. Our findings in combination with dupilumab's favorable safety profile in pediatric AD makes it an appealing option for AA treatment, however, a greater understanding of the underlying mechanisms, optimal pediatric patient selection criteria, long‐term efficacy, and safety profile of dupilumab in this context is warranted.
Identification and characterization of Leptosphaeria biglobosa ‘canadensis’ from wild mustard (Sinapis arvensis) in north‐western China
Authors: Lyv Xing , Jia Donghai , Wu Mingde , Yang Long , Li Guoqing , Zhang Jing 
Published: July 2024

AbstractIn order to understand the epidemiological features of rapeseed blackleg in northern China, a 2‐year survey of blackleg on wild mustard (Sinapis arvensis) and rapeseed (Brassica napus) was done in Zhaosu County of Xinjiang Uyghur Autonomous Region of China. Blackleg frequently occurs on both plants in this region, with mean values of disease incidence reaching up to 28% on wild mustard and 14% on rapeseed. A total of 556 pycnidia‐forming fungal isolates were obtained from wild mustard (69) and rapeseed (487). Morphological and molecular identification indicated that all of the 69 isolates from wild mustard and the majority of the isolates from rapeseed (477/487, 97.9%) belonged to Leptosphaeria biglobosa ‘canadensis’ (Lb‐c); the remaining 10 isolates from rapeseed (10/487, 2.1%) belonged to L. biglobosa ‘brassicae’ (Lb‐b). Among 239 isolates of Lb‐c (62 from wild mustard and 177 from rapeseed), two mating‐type idiomorphs (MAT1‐1 and MAT1‐2) were detected. Chi‐square test showed that the ratio of MAT1‐1 to MAT1‐2 of isolates was 1:1, implying that the individuals of Lb‐c can frequently conduct sexual reproduction to produce ascospores as the primary airborne infection source. The virulence of 10 Lb‐c isolates from wild mustard and rapeseed and five Lb‐b isolates from rapeseed was determined on both plants. The results showed that the Lb‐c isolates from wild mustard were as virulent as isolates of Lb‐c and Lb‐b from rapeseed. Thus, Lb‐c can act as inoculum of rapeseed blackleg, and eliminating plants of wild mustard may improve efficacy of crop rotation in suppression of rapeseed blackleg.
Combined application of myo‐inositol and corn steep liquor enhances seedling growth and cold tolerance in cucumber and tomato
Authors: Sun Shilong , Zhang Xinjun , Wang Cuicui , Yu Qi , Yang Hongli , Xu Weimin , Wang Tao , Gao Lihong , Meng Xiangqing , Luo Sha , Zhang Lianhong , Chen Qing , Zhang Wenna 
Published: July 2024

AbstractLow temperatures pose a common challenge in the production of cucumbers and tomatoes, hindering plant growth and, in severe cases, leading to plant death. In our investigation, we observed a substantial improvement in the growth of cucumber and tomato seedlings through the application of corn steep liquor (CSL), myo‐inositol (MI), and their combinations. When subjected to low‐temperature stress, these treatments resulted in heightened levels of photosynthetic pigments, thereby fostering enhanced photosynthesis in both tomato and cucumber plants. Furthermore, it contributed to a decrease in malondialdehyde (MDA) levels and electrolyte leakage (REP). The effectiveness of the treatment was further validated through the analysis of key gene expressions (CBF1, COR, MIOX4, and MIPS1) in cucumber. Particularly, noteworthy positive outcomes were noted in the treatment involving 0.6 mL L−1 CSL combined with 72 mg L−1 MI. This study provides valuable technical insights into leveraging the synergistic effects of inositol and maize leachate to promote early crop growth and bolster resistance to low temperatures.
Adversity and error‐monitoring: Effects of emotional context
Authors: Compton Rebecca J. , Shudrenko Danylo , Ng Erin , Mann Katelyn , Turdukulov Emil 
Published: July 2024

AbstractThis study tested whether self‐reports of childhood adversity would predict altered error processing under emotional versus non‐emotional task conditions. N = 99 undergraduates completed two selective attention tasks, a traditional color‐word Stroop task and a modified task using emotional words, while EEG was recorded. Participants also completed self‐report measures of adverse and positive childhood experiences, executive functioning, depression, current stress, and emotion regulation. Reports of adversity were robustly correlated with self‐reported challenges in executive functioning, even when controlling for self‐reported depression and stress, but adversity was not correlated with task performance. With regard to neural markers of error processing, adversity predicted an enhanced error‐related negativity and blunted error‐positivity, but only during the emotion‐word blocks of the task. Moreover, error‐related changes in alpha oscillations were predicted by adversity, in a pattern that suggested less error responsiveness in alpha patterns during the emotion block, compared to the color block, among participants with higher adversity. Overall, results indicate alterations in error monitoring associated with adversity, such that in an emotional context, initial error detection is enhanced and sustained error processing is blunted, even in the absence of overt performance changes.
Emotion regulation flexibility: EEG/EMG predictors and consequences of switching between reappraisal and distraction strategies
Authors: Adamczyk Agnieszka K. , Koch Saskia B. J. , Wyczesany Miroslaw , Roelofs Karin , van Peer Jacobien M. 
Published: July 2024

AbstractFlexible use of emotion regulation (ER) strategies is central to mental health. To advance our understanding of what drives adaptive strategy‐switching decisions, in this preregistered study, we used event‐related potentials (late positive potential, LPP and stimulus preceding negativity, SPN) and facial electromyography (EMG corrugator activity) to test the antecedents and consequences of switching to an alternative ER strategy. Participants (N = 63, Mage = 24.8 years, all female) passively watched and then implemented an instructed ER strategy (reappraisal or distraction) in response to high‐intensity negative pictures that were either easy or difficult to reinterpret (high or low reappraisal affordance, respectively). Next, they decided to “switch from” or “maintain” the instructed strategy and subsequently implemented the chosen strategy. Reappraisal affordance manipulations successfully induced switching. Regarding antecedents, switching was predicted by the reduced ER efficacy of the current strategy (corrugator, but not LPP). Switching to distraction was additionally predicted by increased responses to the stimulus during passive viewing (corrugator and LPP) and increased anticipatory effort in implementing reappraisal (SPN). Concerning consequences, switching to distraction improved, whereas switching to reappraisal impaired post‐choice ER effects (LPP). However, starting with reappraisal was overall more effective than starting with distraction, irrespective of the subsequent decision (corrugator). Our results suggest that switching between ER strategies occurs in accordance with situational demands (stimulus affordances) and is predicted by reduced peripheral physiological ER efficacy. However, only switching to distraction leads to improved regulatory effects. These insights provide neurocognitively grounded starting points for developing interventions targeting ER flexibility.
More than just geosmin and 2‐methylisoborneol? Off‐flavours associated with recirculating aquaculture systems
Authors: Noguera Pedro Martínez , Egiddi Matteo , Södergren Julia , da Silva Mariana Rodrigues , Beauchamp Jonathan , Petersen Mikael Agerlin , Buettner Andrea , Jørgensen Niels O. G. 
Published: July 2024

AbstractThe consumption of seafood is driven by flavour, yet achieving its high quality remains a challenge for many species reared in recirculating aquaculture systems (RAS). A comprehensive knowledge of off‐odour sources in aquatic foods is indispensable in ensuring flavour quality standards. At the beginning of the production chain, early post‐harvest lipid oxidation products develop into endogenous off‐odours and accumulate over time. These malodours add to those already absorbed exogenously, namely from the water and feeds, although the information on the interactions between these sources is currently scarce. Despite geosmin and 2‐methylisoborneol receiving significant attention in relation to fish off‐flavour, only limited knowledge on the molecular and ecological mechanisms driving their production in aquatic environments has been reported. Moreover, RAS‐hosted bacteria have been associated with a wide range of other odour‐active compounds, such as pyrazines, terpenoids, and other degradation byproducts that are frequently overlooked when studying flavour taint in fish. The influence of aquaculture feeds on the flavour of fish flesh has been underestimated, too, both as a source of off‐odours but also as a novel modulator strategy to achieve desirable aquatic food flavours. Finally, the influence of water treatment processes widely used in RAS operations, such as advance oxidation process, ozone, ultraviolet and hydrogen peroxide disinfections, is greatly underexplored with respect to odour quality. This article reviews the current scientific evidence with supporting data on the chemical diversity of off‐odours found in aquaculture fish worldwide and their potential sources and highlights knowledge gaps that should be addressed in future research.