bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strong Downslope Wind Events in Ammassalik, Southeast Greenland
Authors: Oltmanns M. , Straneo F. , Moore G. W. K. , Mernild S. H. 
Published: September 2013

Abstract
Ammassalik in southeast Greenland is known for strong wind events that can reach hurricane intensity and cause severe destruction in the local town. Yet, these winds and their impact on the nearby fjord and shelf region have not been studied in detail.
Here, data from two meteorological stations and the European Centre for Medium-Range Weather Forecasts Interim Re-Analysis (ERA-Interim) are used to identify and characterize these strong downslope wind events, which are especially pronounced at a major east Greenland fjord, Sermilik Fjord, within Ammassalik. Their local and regional characteristics, their dynamics and their impacts on the regional sea ice cover, and air–sea fluxes are described. Based on a composite of the events it is concluded that wind events last for approximately a day, and seven to eight events occur each winter. Downslope wind events are associated with a deep synoptic-scale cyclone between Iceland and Greenland. During the events, cold dry air is advected down the ice sheet. The downslope flow is accelerated by gravitational acceleration, flow convergence inside the Ammassalik valley, and near the coast by an additional thermal and synoptic-scale pressure gradient acceleration. Wind events are associated with a large buoyancy loss over the Irminger Sea, and it is estimated that they drive one-fifth of the net wintertime loss. Also, the extreme winds drive sea ice out of the fjord and away from the shelf.
The Multidecadal Atlantic SST—Sahel Rainfall Teleconnection in CMIP5 Simulations
Authors: Martin Elinor R. , Thorncroft Chris , Booth Ben B. B. 
Published: September 2013

Abstract
This study uses models from phase 5 of the Coupled Model Intercomparison Project (CMIP5) to evaluate and investigate Sahel rainfall multidecadal variability and teleconnections with global sea surface temperatures (SSTs). Multidecadal variability is lower than observed in all historical simulations evaluated. Focus is on teleconnections with North Atlantic SST [Atlantic multidecadal variability (AMV)] as it is more successfully simulated than the Indian Ocean teleconnection. To investigate why some models successfully simulated this teleconnection and others did not, despite having similarly large AMV, two groups of models were selected. Models with large AMV were highlighted as good (or poor) by their ability to simulate relatively high (low) Sahel multidecadal variability and have significant (not significant) correlation between multidecadal Sahel rainfall and an AMV index. Poor models fail to capture the teleconnection between the AMV and Sahel rainfall because the spatial distribution of SST multidecadal variability across the North Atlantic is incorrect. A lack of SST signal in the tropical North Atlantic and Mediterranean reduces the interhemispheric SST gradient and, through circulation changes, the rainfall variability in the Sahel. This pattern was also evident in the control simulations, where SST and Sahel rainfall variability were significantly weaker than historical simulations. Errors in SST variability were suggested to result from a combination of weak wind–evaporation–SST feedbacks, poorly simulated cloud amounts and feedbacks in the stratocumulus regions of the eastern Atlantic, dust–SST–rainfall feedbacks, and sulfate aerosol interactions with clouds. By understanding the deficits and successes of CMIP5 historical simulations, future projections and decadal hindcasts can be examined with additional confidence.
The Subalar Graft and Its Role in Nasal Tip Medialization and Improved Nostril Symmetry
Authors: Aynehchi Behrad B. , Mascaro Miguel E. , Rosenfeld Richard M. , Westreich Richard W. 
Published: September 2013

ObjectivesRelationships between nasal axis deviation and lower midfacial asymmetry or hypoplasia have been established in prior studies. We describe our experience with the subalar grafting technique in addressing nasal tip deviation associated with facial asymmetry. Indications in using this graft in isolation or in conjunction with other tip modification techniques are also investigated.Study DesignRetrospective case series.SettingAcademic medical center.Subjects and MethodsThirty‐seven consecutive patients from a single surgeon (R.W.W.) treated using subalar grafting are evaluated for correction. Various measurements from preoperative and postoperative photographs are analyzed to determine the effectiveness of this intervention.ResultsStatistically significant correlations between improvement in nasal axis and alar‐facial angle on base view (AFAB) (P<. 001) and between alar‐facial angle on frontal view (AFAF) (P=. 017) were observed. In addition, a significant correlation between AFAB improvement and AFAF normalization was observed (P<. 001). The improved nostril symmetry was significantly correlated with base view correction and was not the result of general improvements in nasal deviation.ConclusionWhile measuring the independent effects of subalar grafting is limited due to contaminant procedures, it can be recognized as a foundation rhinoplasty technique that, in conjunction with septoplasty, provides medialization of the tip in patients with facial asymmetry. Furthermore, aesthetic correction of nostril horizontal dystopia and/or nostril “show” is achieved with the proper application of this technique. This correction represents a unique intervention in rhinoplasty and should be considered a second indication for its use.
Using the Inequitable Gender Norms Scale and Associated HIV Risk Behaviors among Men at High Risk for HIV in Ghana and Tanzania
Authors: Shattuck Dominick , Burke Holly , Ramirez Catalina , Succop Stacey , Costenbader Betsy , Attafuah John Dekyem , Mndeme Erasmus , Mbwambo Jessie , Guest Greg 
Published: September 2013

Context: Gender norms influence unintended pregnancy, maternal health, HIV/AIDS infection, and act as barriers to reproductive health services. The Gender Equitable Men (GEM) scale has been used widely in programs and research in African settings, but it has yet to be statistically validated. Method: We examined the internal and external validity of the Inequitable Gender Norms (IGN) subscale of the GEM scale in Tanzania and Ghana using a two-step, mixed-method process. Confirmatory factor analysis tested the internal validity of the subscale and regression tests identified associations between the IGN scale and several HIV risk-related variables. Results: The IGN scale was shown to be a useful measure of gender norms in both countries. Excluding two questions that measured attitudes toward homosexuality, the scale met the hypothesized single factor structure. Furthermore, the IGN scores were significantly associated with several HIV risk variables in both samples. Conclusions: The IGN scale is a robust measure of gender norms in these African countries. However, the role of attitudes toward homosexuality as a contributor to gender norms measurement needs further exploration. Our analyses provide a basis for using the IGN scale to provide a contextualized understanding of men’s perceptions of gender norms and to evaluate programs focused more equitable gender norms. We are aware of only one other measure of gender norms that has been statistically validated in the African Context.
Hybrid pig versus Göttingen minipig-derived cartilage and chondrocytes show pig line-dependent differences
Authors: Müller Claudia , Marzahn Ulrike , Kohl Benjamin , Sayed Karym El , Lohan Anke , Meier Carola , Ertel Wolfgang , Schulze-Tanzil Gundula 
Published: September 2013

Minipigs are widely used as a large animal model for cartilage repair. However, many in vitro studies are based on porcine chondrocytes derived from abundantly available premature hybrid pigs. It remains unclear whether pig line-dependent differences exist which could limit the comparability between in vitro and in vivo results using either hybrid or miniature pig articular chondrocytes. Porcine knee joint femoral cartilage was isolated from 3- to 5-month-old hybrid pigs and Göttingen minipigs. Cartilage from both pig lines was analysed for thickness, zonality, cell content, size and proteoglycan deposition. Cultured articular chondrocytes from both pig lines were investigated for gene and/or protein expression of cartilage-specific proteins such as type II collagen, aggrecan, the chondrogenic transcription factor Sox9, non-specific type I collagen and the cell-matrix receptor β1-integrin. Cartilage was significantly thinner in the miniature pig compared to the hybrid pig, but the differences between the medial and lateral femur condyles did not reach a significant level. Knee joint cartilage zone formation started only in the minipig, whereas cellularity and cell diameters were comparable in both pig lines. Blood vessels could be detected in the hybrid pig but not the minipig cartilage. Sulphated proteoglycan deposition was more pronounced in cartilage zones II–IV of both pig lines. Minipig chondrocytes expressed type II and I collagen, Sox9 and β1-integrin at a higher level than hybrid pig chondrocytes. These distinct line-dependent differences should be considered when using hybrid pig-derived chondrocytes for tissue engineering and Göttingen minipigs as a large animal model.
Diabetes Mellitus and Aortic Aneurysm Rupture
Authors: Theivacumar Nada Selva , Stephenson Matthew A. , Mistry Hiren , Valenti Domenico 
Published: September 2013

Introduction: Recent reports suggest that diabetic patients are relatively unlikely to have abdominal aortic aneurysms (AAAs). This retrospective study assesses the relationship between diabetes mellitus (DM) and aortic aneurysm rupture. Methods: Patients with a diagnosis of any aortic aneurysm during a 10-year period were identified from our records. Patients with diagnoses of aortic aneurysm (thoracic, thoracoabdominal, and abdominal, treated and untreated) were included. Patients with nonatheromatous aneurysms (transection, dissection, mycotic, or isolated iliac) were excluded. Results: In all, 1830 patients with nonruptured aneurysms and 232 ruptured aneurysms were included giving a total of 2062 patients with aortic aneurysms (abdominal, thoracic, and thoracoabdominal). Of these 1830, 225 (12.3%) patients with nonruptured aneurysm were diabetic; however, only 13 (5.6%) of the 232 patients with ruptured aortic aneurysm were diabetic (odds ratio [OR] = 0.42; confidence interval [CI]: 0.23-0.75, P = .004). Considering only those with AAAs, 184 (12.4%) of the 1482 nonruptured AAA were diabetic; however, only 12 (6.4%) of the 188 patients with ruptured AAA were diabetic (OR = 0.48 [CI: 0.26-0.88], P = .02). In this study group, the odds of dying due to aneurysm rupture in the diabetic group are significantly lower compared to the nondiabetic groups (OR = 0.31 [CI: 0.13-0.69], P = .004), despite the finding that diabetic patients had almost the same life expectancy as nondiabetic patients (DM, 73 years [67-80] vs non-DM, 75 years [68-82] P = .23). Conclusions: Diabetic patients with aortic aneurysms are significantly less likely to present with rupture or to die from aneurysm rupture when compared to nondiabetic patients with aortic aneurysms. We have identified association only, not causality. However, it is plausible that DM, or the treatment of DM, may have a protective effect on aortic aneurysm rupture.
The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells
Authors: Yamada Mitsuhiro , Kubo Hiroshi , Ota Chiharu , Takahashi Toru , Tando Yukiko , Suzuki Takaya , Fujino Naoya , Makiguchi Tomonori , Takagi Kiyoshi , Suzuki Takashi , Ichinose Masakazu 
Published: September 2013

Abstract

Background
The excess and persistent accumulation of fibroblasts due to aberrant tissue repair results in fibrotic diseases such as idiopathic pulmonary fibrosis. Recent reports have revealed significant changes in microRNAs during idiopathic pulmonary fibrosis and evidence in support of a role for microRNAs in myofibroblast differentiation and the epithelial-mesenchymal transition in the context of fibrosis. It has been reported that microRNA-21 is up-regulated in myofibroblasts during fibrosis and promotes transforming growth factor-beta signaling by inhibiting Smad7. However, expression changes in microRNA-21 and the role of microRNA-21 in epithelial-mesenchymal transition during lung fibrosis have not yet been defined.

Methods
Lungs from saline- or bleomycin-treated C57BL/6 J mice and lung specimens from patients with idiopathic pulmonary fibrosis were analyzed. Enzymatic digestions were performed to isolate single lung cells. Lung epithelial cells were isolated by flow cytometric cell sorting. The expression of microRNA-21 was analyzed using both quantitative PCR and in situ hybridization. To induce epithelial-mesenchymal transition in culture, isolated mouse lung alveolar type II cells were cultured on fibronectin-coated chamber slides in the presence of transforming growth factor-β, thus generating conditions that enhance epithelial-mesenchymal transition. To investigate the role of microRNA-21 in epithelial-mesenchymal transition, we transfected cells with a microRNA-21 inhibitor. Total RNA was isolated from the freshly isolated and cultured cells. MicroRNA-21, as well as mRNAs of genes that are markers of alveolar epithelial or mesenchymal cell differentiation, were quantified using quantitative PCR.

Results
The lung epithelial cells isolated from the bleomycin-induced lung fibrosis model system had decreased expression of epithelial marker genes, whereas the expression of mesenchymal marker genes was increased. MicroRNA-21 was significantly upregulated in isolated lung epithelial cells during bleomycin-induced lung fibrosis and human idiopathic pulmonary fibrosis. MicroRNA-21 was also upregulated in the cultured alveolar epithelial cells under the conditions that enhance epithelial-mesenchymal transition. Exogenous administration of a microRNA-21 inhibitor prevented the increased expression of vimentin and alpha-smooth muscle actin in cultured primary mouse alveolar type II cells under culture conditions that induce epithelial-mesenchymal transition.

Conclusions
Our experiments demonstrate that microRNA-21 is increased in lung epithelial cells during lung fibrosis and that it promotes epithelial-mesenchymal transition.
Large-scale multiple testing in genome-wide association studies via region-specific hidden Markov models
Authors: Xiao Jian , Zhu Wensheng , Guo Jianhua 
Published: September 2013

AbstractBackgroundIdentifying genetic variants associated with complex human diseases is a great challenge in genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) arising from genetic background are often dependent. The existing methods, i.e., local index of significance (LIS) and pooled local index of significance (PLIS), were both proposed for modeling SNP dependence and assumed that the whole chromosome follows a hidden Markov model (HMM). However, the fact that SNP data are often collected from separate heterogeneous regions of a single chromosome encourages different chromosomal regions to follow different HMMs. In this research, we developed a data-driven penalized criterion combined with a dynamic programming algorithm to find change points that divide the whole chromosome into more homogeneous regions. Furthermore, we extended PLIS to analyze the dependent tests obtained from multiple chromosomes with different regions for GWAS.ResultsThe simulation results show that our new criterion can improve the performance of the model selection procedure and that our region-specific PLIS (RSPLIS) method is better than PLIS at detecting disease-associated SNPs when there are multiple change points along a chromosome. Our method has been used to analyze the Daly study, and compared with PLIS, RSPLIS yielded results that more accurately detected disease-associated SNPs.ConclusionsThe genomic rankings based on our method differ from the rankings based on PLIS. Specifically, for the detection of genetic variants with weak effect sizes, the RSPLIS method was able to rank them more efficiently and with greater power.
HANDS: a tool for genome-wide discovery of subgenome- specific base-identity in polyploids
Authors: Mithani Aziz , Belfield Eric J , Brown Carly , Jiang Caifu , Leach Lindsey J , Harberd Nicholas P 
Published: September 2013

Abstract

Background
The analysis of polyploid genomes is problematic because homeologous subgenome sequences are closely related. This relatedness makes it difficult to assign individual sequences to the specific subgenome from which they are derived, and hinders the development of polyploid whole genome assemblies.

Results
We here present a next-generation sequencing (NGS)-based approach for assignment of subgenome-specific base-identity at sites containing homeolog-specific polymorphisms (HSPs): ‘HSP base Assignment using NGS data through Diploid Similarity’ (HANDS). We show that HANDS correctly predicts subgenome-specific base-identity at >90% of assayed HSPs in the hexaploid bread wheat (Triticum aestivum) transcriptome, thus providing a substantial increase in accuracy versus previous methods for homeolog-specific base assignment.

Conclusion
We conclude that HANDS enables rapid and accurate genome-wide discovery of homeolog-specific base-identity, a capability having multiple applications in polyploid genomics.
Genetic analysis of the FBXO42 gene in Chinese Han patients with Parkinson’s disease
Authors: Gao Kai , Deng Xiong , Zheng Wen , Song Zhi , Zhu Anding , Xiu Xiaofei , Deng Hao 
Published: September 2013

AbstractBackgroundParkinson’s disease (PD), the second most common neurodegenerative disease, is characterized by loss of dopaminergic neurons in the substantia nigra. The clinical manifestations of PD encompass a variety of motor and non-motor symptoms. Mutations in the F-box protein 7 gene (FBXO7) have been identified to cause Parkinsonian-pyramidal syndrome, an autosomal recessive form of Parkinsonism. The F-box protein 42 gene (FBXO42), a paralog of theFBXO7gene, is involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of PD.MethodsTo determine whether theFBXO42gene is associated with PD, we performed a systematic genetic analysis of theFBXO42gene in 316 PD patients and 295 gender-, age-, and ethnicity-matched normal controls.ResultsWe identified a novel variant c.1407T>C (p.S469S) and three known single nucleotide variants, including rs2273311, rs12069239 and rs35196193 in theFBXO42gene in PD patient group. None of the three known variants displayed statistically significant difference in either genotypic or allelic distributions between patient and control groups (allP> 0.05). Haplotype analysis showed that a common haplotype (G-C-G) for the three single nucleotide variants conferred a 1.69-fold increased risk for PD (P= 0.008 after Bonferroni correction, OR = 1.69, 95% CI = 1.06-2.71).ConclusionsOur findings suggest that a haplotype of theFBXO42gene might be associated with a higher susceptibility to PD.
Unusual epileptic deterioration and extensive white matter lesion during treatment in Wilson’s disease
Authors: Kim Young Eun , Yun Ji Young , Yang Hui-Jun , Kim Han-Joon , Jeon Beom S 
Published: September 2013

Abstract

Background
Wilson’s disease (WD) is a genetic disorder which can be controlled fairly well with decupuration therapy. However, symptoms, on rare occasions, can worsen even when WD is being treated. Herein, we report a case involving unusual neurological deterioration during decupuration therapy for WD.

Case presentation
A 28-year-old man was diagnosed with WD 13 years prior to his clinical visit; however, his drug compliance has been poor over the years. He was treated with trientine because tremors and dysarthria have presented in recent years. However, dysarthria and dystonia developed in his limbs, which were worse on the right side and had been aggravated for several weeks despite good drug compliance. His symptoms were fluctuating. It was initially misdiagnosed as dystonia; although, it turned out to be a seizure due to cortical degeneration. These symptoms were completely resolved with antiepileptic drugs. Moreover, the cortical enhancement of bifrontal degeneration has disappeared on the MRI.

Conclusion
This case showed unusual epileptic neurologic deterioration due to cortical degeneration during decupuration therapy. Seizures in WD can easily be mistaken as part of dystonia. However, the fluctuating symptoms suggest a seizure.
Bohler’s angle’s role in assessing the injury severity and functional outcome of internal fixation for displaced intra-articular calcaneal fractures: a retrospective study
Authors: Su Yanling , Chen Wei , Zhang Tao , Wu Xingwang , Wu Zhanpo , Zhang Yingze 
Published: September 2013

AbstractBackgroundControversy exits over the role of Böhler’s angle in assessing the injury severity of displaced intra-articular calcaneal fractures and predicting the functional outcome following internal fixation. This study aims to investigate whether a correlation exists between Böhler’s angle and the injury severity of displaced calcaneal fractures, and between surgical improvement of Böhler’s angle and functional outcome.MethodsPatients treated operatively for unilateral closed displaced intra-articular calcaneal fractures from January 1, 2004 to March 31, 2008 were identified. The Böhler’s angles of both calcaneus were measured, and the measurement of the uninjured foot was used as its normal control. The difference in the value of Böhler’s angle measured preoperatively or postoperatively between the angle of the injured foot and that of the contralateral calcaneus were calculated, respectively. The change in Böhler’s angle by ratio was calculated by dividing the difference value of Böhler’s angle between bilateral calcaneus by its normal control. The injury severity was assessed according to Sanders classification. The functional outcomes were assessed using American Orthopaedic Foot & Ankle Society hindfoot scores.Results274 patients were included into the study with a mean follow-up duration of 71 months. According to Sanders classification, the fracture pattern included 105 type II, 121 type III and 48 type IV fractures. According to American Orthopaedic Foot & Ankle Society hindfoot scoring system, the excellent, good, fair and poor results were achieved in 104, 132, 27, and 11 patients, respectively. The preoperative Böhler’s angle, difference value of Böhler’s angle between bilateral calcaneus, and change in Böhler’s angle by ratio each has a significant correlation with Sanders classification (rs=−0.178,P=0.003; rs=−0.174,P=0.004; rs=−0.172,P=0.005, respectively), however, is not correlated with functional outcome individually. The three postoperative measurements were all found to have a significant correlation with American Orthopaedic Foot & Ankle Society hindfoot scores (rs=0.223,P<0.001; rs=0.224,P<0.001; rs=0.220,P<0.001, respectively). However, these correlations were all weak to low.ConclusionsThere was a significant correlation between preoperative Böhler’s angle and the injury severity of displaced intra-articular calcaneal fractures, but only postoperative Böhler’s angle parameters were found to have a significant correlation with the functional recovery.
Optimal receiver antenna location in indoor environment using dynamic differential evolution and genetic algorithm
Authors: Liao Shu-Han , Chen Chien-Hung , Chiu Chien-Ching , Ho Min-Hui , Wysocki Tadeusz A , Wysocki Beata J 
Published: September 2013

Abstract
Using the impulse responses of these multipath channels, the bit error rate (BER) performance for binary pulse amplitude modulation impulse radio ultra-wideband communication system is calculated. The optimization location of receiving antenna is investigated by dynamic differential evolution (DDE) and genetic algorithm (GA) to minimize the outage probability. Numerical results show that the performance for reducing BER and outage probability by DDE algorithm is better than that by GA.