bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photochromic Property of Anionic Spiropyran with Sulfonate-substituted Indoline Moiety
Authors: Sugahara Akira , Tanaka Naru , Okazawa Atsushi , Matsushita Nobuyuki , Kojima Norimichi 
Published: November 2013

Abstract
For fabricating photoresponsive multifunctional materials, we have developed the potassium salt of a new anionic spiropyran, 1′,3′,3′-trimethyl-6-nitrospiro[2H-1-benzopyran-2,2′-indoline]-5′-sulfonate (1−), with the sulfonate group present on the indoline moiety and whose crystal structure was revealed by single-crystal X-ray diffraction analysis. The photochromism of 1·K was demonstrated at room temperature in the KBr-diluted state, as well as in solution. The protonated spiropyran 1H shows negative photochromism.
Iridium-catalyzed Asymmetric Hydrogenation of Pyridinium Salts for Constructing Multiple Stereogenic Centers on Piperidines
Authors: Kita Yusuke , Iimuro Atsuhiro , Hida Shoji , Mashima Kazushi 
Published: November 2013

Abstract
A salt formation strategy for asymmetric hydrogenation of pyridines is described. Poly-substituted pyridinium salts were successfully hydrogenated using chiral iridium dinuclear complexes to afford substituted piperidines with multiple stereogenic centers after a simple basic workup.
ISMP Medication Error Report Analysis - Leucovorin-Levoleucovorin Mix-Up; Two Error-Reduction Principles, One Change; Syringe Pull-Back Method of Verifying IV Admixtures is Unreliable; Fleet Enema Saline is not Just Saline; ISMP Processes Health it Error Reports
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: November 2013

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers’ names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters’ wishes as to the level of detail included in publications.
Implementation of an Order Set to Adhere to National Patient Safety Goals for Warfarin Therapy
Authors: Nisly Sarah , Shiltz Erin D. , VanArsdale Vanessa , Laughlin Jordyn 
Published: November 2013

Background In 2009, The Joint Commission mandated full compliance with National Patient Safety Goal (NPSG) 03.05.01 to reduce the likelihood of patient harm associated with anticoagulant therapy. Methods We conducted a retrospective chart review of inpatients receiving warfarin at Methodist Hospital pre and post implementation of a warfarin order set between January 2008 and July 2011. The primary endpoint of this study was overall adherence to laboratory monitoring. Secondary endpoints included compliance with individual laboratory parameters, percentage of patient educational sessions completed prior to discharge, and percentage of appropriate follow-up arrangements documented on discharge. Results A total of 707 patients were assessed. Overall adherence to laboratory monitoring parameters significantly improved from 71.8% to 87.5% (odds ratio [OR], 2.76; 95% CI, 1.87- 4.07; P < .001). Additional improvements were seen in patient education prior to discharge, and appropriate follow-up arrangements were documented at discharge. Conclusions This analysis demonstrates that implementation of an order set assists in adherence to policies and procedures designed to address the NPSG 03.05.01. Additionally, pharmacy involvement in monitoring, educating, and arranging for follow-up may lead to successful completion of these parameters.
Comparison of mRNA Splicing Assay Protocols across Multiple Laboratories: Recommendations for Best Practice in Standardized Clinical Testing
Authors: Whiley Phillip J , de la Hoya Miguel , Thomassen Mads , Becker Alexandra , Brandão Rita , Pedersen Inge Sokilde , Montagna Marco , Menéndez Mireia , Quiles Francisco , Gutiérrez-Enríquez Sara , De Leeneer Kim , Tenés Anna , Montalban Gemma , Tserpelis Demis , Yoshimatsu Toshio , Tirapo Carole , Raponi Michela , Caldes Trinidad , Blanco Ana , Santamariña Marta , Guidugli Lucia , de Garibay Gorka Ruiz , Wong Ming , Tancredi Mariella , Fachal Laura , Ding Yuan Chun , Kruse Torben , Lattimore Vanessa , Kwong Ava , Chan Tsun Leung , Colombo Mara , De Vecchi Giovanni , Caligo Maria , Baralle Diana , Lázaro Conxi , Couch Fergus , Radice Paolo , Southey Melissa C , Neuhausen Susan , Houdayer Claude , Fackenthal Jim , Hansen Thomas Van Overeem , Vega Ana , Diez Orland , Blok Rien , Claes Kathleen , Wappenschmidt Barbara , Walker Logan , Spurdle Amanda B , Brown Melissa A 
Published: November 2013

Abstract

BACKGROUND
Accurate evaluation of unclassified sequence variants in cancer predisposition genes is essential for clinical management and depends on a multifactorial analysis of clinical, genetic, pathologic, and bioinformatic variables and assays of transcript length and abundance. The integrity of assay data in turn relies on appropriate assay design, interpretation, and reporting.

METHODS
We conducted a multicenter investigation to compare mRNA splicing assay protocols used by members of the ENIGMA (Evidence-Based Network for the Interpretation of Germline Mutant Alleles) consortium. We compared similarities and differences in results derived from analysis of a panel of breast cancer 1, early onset (BRCA1) and breast cancer 2, early onset (BRCA2) gene variants known to alter splicing (BRCA1: c.135-1G&gt;T, c.591C&gt;T, c.594-2A&gt;C, c.671-2A&gt;G, and c.5467+5G&gt;C and BRCA2: c.426-12_8delGTTTT, c.7988A&gt;T, c.8632+1G&gt;A, and c.9501+3A&gt;T). Differences in protocols were then assessed to determine which elements were critical in reliable assay design.

RESULTS
PCR primer design strategies, PCR conditions, and product detection methods, combined with a prior knowledge of expected alternative transcripts, were the key factors for accurate splicing assay results. For example, because of the position of primers and PCR extension times, several isoforms associated with BRCA1, c.594-2A&gt;C and c.671-2A&gt;G, were not detected by many sites. Variation was most evident for the detection of low-abundance transcripts (e.g., BRCA2 c.8632+1G&gt;A Δ19,20 and BRCA1 c.135-1G&gt;T Δ5q and Δ3). Detection of low-abundance transcripts was sometimes addressed by using more analytically sensitive detection methods (e.g., BRCA2 c.426-12_8delGTTTT ins18bp).

CONCLUSIONS
We provide recommendations for best practice and raise key issues to consider when designing mRNA assays for evaluation of unclassified sequence variants.
Evaluating Attitudes Toward Workplace Support for Breastfeeding Among Hospital Managers
Authors: Rojjanasrirat Wilaiporn , Ferrarello Debi Page 
Published: November 2013

Background: Although the Patient Protection and Affordable Health Care Act has become a law, the enforcement provisions of the legislation are limited. Identifying attitudes and beliefs held by managerial roles may uncover barriers to breastfeeding support in the workplace and
guide International Board Certified Lactation Consultants (IBCLCs) who are designing workplace support programs.Objective: The objectives were (a) to identify factors influencing managers’, service line directors’, and administrators’ attitudes about support for breastfeeding;
(b) to develop a BreastfeedingFriendly Workplace Initiative addressing the identified factors; and (c) to assess the effectiveness of the initiatives in changing employers’ attitudes about support for breastfeeding in the workplace.Methods: This descriptive study was conducted
from November 2010 to January 2011 in an urban academic medical center. Self-report, pretest, and posttest questionnaires were used in a convenience sample of 49 supervisors, managers, administrators, and charge nurses.Results: Following the implementation of the Breastfeeding-Friendly
Workplace program, the overall managers’ perceptions and attitudes toward providing breastfeeding support were positive. Posttest scores revealed that most people in managerial roles rated their intent, subjective norms, personal beliefs, and having control over providing support to breastfeeding
working women higher than the baseline mean scores.Conclusions: Findings demonstrated that managers’ perceptions, beliefs, attitudes, and intention to support breastfeeding improved the implementation of the hospital breastfeedingsupport program. Future research is needed to evaluate
the effectiveness of the workplace lactation program on the duration and exclusivity of breastfeeding among employed mothers.
Effects of Nutritional Supplementation on Prealbumin Concentrations in
Pediatric Burn Patients: A Randomized, Controlled Trial
Authors: Williams Jennifer A. , Yankina Anna , Choe Yong S. , Dokukina Lyudmila , Brazol Marina , Altshuler Evgeniy , Gordon Mikhail , Ostrovskiy Nikolay , Kuraev Evgeniy , Marriage Barbara J. 
Published: November 2013

Introduction:
This prospective, randomized study was designed to measure the effect of nutritional supplementation
on serum prealbumin (transthyretin) in pediatric burn patients in seven burn centers in Russia. The primary measure
was change in serum prealbumin from baseline to Day 7.

Methods:
Fifty-four children age 1-10 years with a TBSA burn of at least 15% were enrolled into this study. Patients had
baseline serum prealbumin levels > 10 mg/dL and were capable of exclusive oral feeding within 72 hours of hospitalization.
One-hundred-sixteen children were screened, with 54 meeting eligibility criteria, 28 subjects in the control group and
26 in the supplement group. Patients were randomized to receive the typical hospital diet for mild to moderate burn patients
or the same diet plus additional oral nutritional supplementation. The additional enteral supplementation was 299
kcal/day for most of the subjects.

Results:
Nutritional supplementation significantly increased serum prealbumin levels of the subjects from baseline to Day
7. At Day 7, children consuming the supplementation had a mean ± standard error change in prealbumin concentration of
8.44 ± 1.13 mg/dL and children on hospital diet only had a change of 5.47 ± 0.80 mg/dL, with a difference of 2.97 mg/dL
(p=0.0265). There were no significant differences in baseline serum prealbumin concentration, nor were there differences
for adverse events or safety concerns related to study product.

Conclusions:
The increase of prealbumin related to enteral supplementation may provide future guidance for nutritional
management of pediatric burn patients or patients with increased energy and protein needs.
New Combined Serum Creatinine and Cystatin C Quadratic Formula for GFR Assessment in Children
Authors: Chehade Hassib , Cachat Francois , Jannot Anne-Sophie , Meyrat Blaise-Julien , Mosig Dolores , Bardy Daniel , Parvex Paloma , Girardin Eric 
Published: November 2013

Summary

Background and objectives
The estimated GFR (eGFR) is important in clinical practice. To find the best formula for eGFR, this study assessed the best model of correlation between sinistrin clearance (iGFR) and the solely or combined cystatin C (CysC)– and serum creatinine (SCreat)–derived models. It also evaluated the accuracy of the combined Schwartz formula across all GFR levels.

Design, setting, participants, & measurements
Two hundred thirty-eight iGFRs performed between January 2012 and April 2013 for 238 children were analyzed. Regression techniques were used to fit the different equations used for eGFR (i.e., logarithmic, inverse, linear, and quadratic). The performance of each model was evaluated using the Cohen κ correlation coefficient and the percentage reaching 30% accuracy was calculated.

Results
The best model of correlation between iGFRs and CysC is linear; however, it presents a low κ coefficient (0.24) and is far below the Kidney Disease Outcomes Quality Initiative targets to be validated, with only 84% of eGFRs reaching accuracy of 30%. SCreat and iGFRs showed the best correlation in a fitted quadratic model with a κ coefficient of 0.53 and 93% accuracy. Adding CysC significantly (P<0.001) increased the κ coefficient to 0.56 and the quadratic model accuracy to 97%. Therefore, a combined SCreat and CysC quadratic formula was derived and internally validated using the cross-validation technique. This quadratic formula significantly outperformed the combined Schwartz formula, which was biased for an iGFR≥91 ml/min per 1.73 m2.

Conclusions
This study allowed deriving a new combined SCreat and CysC quadratic formula that could replace the combined Schwartz formula, which is accurate only for children with moderate chronic kidney disease.
Body Fat Content and Distribution and Urinary Risk Factors for Nephrolithiasis
Authors: Pigna Federica , Sakhaee Khashayar , Adams-Huet Beverley , Maalouf Naim M. 
Published: November 2013

Summary

Background and objectives
Obesity is associated with a higher risk of nephrolithiasis. However, it is not known whether higher body fat mass or abnormal fat distribution influences stone risk independent of dietary factors.

Design, setting, participants, & measurements
In this cross-sectional study, non–stone-forming men with no known kidney disease and with a wide range of body weight collected a 24-hour urine specimen while consuming a fixed metabolic diet. They underwent dual-energy x-ray absorptiometry to assess body composition and fat distribution. Urinary risk factors for nephrolithiasis and urine saturation with respect to calcium oxalate and uric acid (assessed as supersaturation index [SI]) were correlated with various measures of adiposity.

Results
Study participants included 21 men with a mean age of 52.1 years, mean weight of 91.1 kg, and mean total fat mass of 24.3 kg. Twenty-four-hour urine pH and SI uric acid were more closely correlated with fat mass than with lean mass or total body weight. Both 24-hour urine pH and SI uric acid were also significantly correlated with truncal fat mass but not with leg fat mass. Moreover, there was a significant negative correlation between truncal/leg fat mass and NH4
+/net acid excretion ratio (R=−0.62; P=0.009). However, there was no significant association between SI calcium oxalate and body weight, lean mass, fat mass, trunk fat mass, or leg fat mass.

Conclusions
The association between 24-hour urine pH and SI uric acid and various measures of adiposity suggest that total body fat and trunk fat are more strongly associated with risk factors for uric acid stone formation than are total body weight and lean body mass. Under a controlled metabolic diet, adiposity is not associated with risk factors for calcium oxalate stones. Further studies are needed to confirm these findings in larger populations that include women and patients who form stones.
sRAGE is associated with low waist circumference and Hb levels in NAFLD
Authors: Hyogo Hideyuki , Yamagishi Sho-ichi , Maeda Sayaka , Nakahara Takashi , Kimura Yuki , Chayama Kazuaki 
Published: November 2013

Abstract
Advanced glycation end products (AGEs) and the receptor RAGE interaction is involved in nonalcoholic fatty liver disease (NAFLD). Although exogenously administered soluble RAGE (sRAGE) has been shown to block the harmful effects of AGEs in animal models, there is still controversy about the role of sRAGE in humans. We examined here which anthropometric, metabolic and clinical variables were independent correlates of sRAGE levels in NAFLD patients. The study involved 77 biopsy-proven, unmedictaed NAFLD patients (44 male and 33 female) with a mean age of 43.4±13.0 years old. We examined which anthropometric, metabolic and clinical variables, including liver steatosis and fibrosis markers, are independently associated with serum levels of sRAGE. Mean serum levels of sRAGE were 710.7±290.2 pg/mL. Univariate analysis revealed that waist circumference (inversely), hemoglobin (inversely), number of white blood cells (inversely), total-bilirubin (inversely), free fatty acid (inversely), ferritin (inversely), and HbA1c (inversely) were significantly correlated with serum levels of sRAGE. In multiple stepwise regression analysis, waist circumference (p<0.01, inversely) and hemoglobin (p<0.01, inversely) were independently associated with serum levels of sRAGE (R2=0.176). The present study reveals that low serum levels of sRAGE are independently associated with waist circumference and hemoglobin in patients with NAFLD.
Ischemic and non-ischemic dilated cardiomyopathy
Authors: Fazio Giovanni , Vernuccio Federica , Grassedonio Emanuele , Grutta Giuseppe , Lo Re Giuseppe , Midiri Massimo 
Published: November 2013

Abstract
Dilated Cardiomyopathy is a high-incident disease, which diagnosis of and treatments are clinical priority. The aim of our study was to evaluate the diagnostic potential of cardiac magnetic resonance (CMR) imaging; echocardiography and the biochemical parameters that can help us differentiate between the post-ischemic and non-ischemic dilated cardiomyopathy. Materials and methods. The study enrolled 134 patients with dilated cardiomyopathy: 74 with the post-ischemic form and 60 with the non-ischemic one. All patients underwent a coronary imaging test, with echocardiogram, cardiac magnetic resonance and a blood test. Pro-inflammatory cytokines were evaluated using Luminex kit. Data was compared between the two groups. Results. Echocardiography allowed recognition of Left Ventricular Non Compaction in 2 patients. Longitudinal and circumferential strains were significantly different in the two groups (p<0.05). Using CMR imaging a post-myocarditis scar was diagnosed in 2 patients and a post-ischemic scar in 95% of patients with the chronic ischemic disease. The interleukin IL-1, IL-6 and TNF-α levels were higher in the post-ischemic group compared with the non-ischemic one. Conclusions. The use of second level techniques with a high sensitivity and specificity would help distinguish among different sub-forms of dilated cardiomyopathy.
Thyroid dysfunction and cardiovascular risk factors in Bulgarian adults
Authors: Shinkov Alexander , Borissova Anna-Maria , Kovatcheva Roussanka , Vlahov Jordan , Dakovska Lilia , Atanassova Iliana , Vukov Mirtcho , Aslanova Nina 
Published: November 2013

Abstract
The aim of this study was to determine the prevalence of thyroid dysfunction and its association with cardiovascular risk factors in an adult Bulgarian population. 2402 subjects were studied, 1347 female, 20–94y (median: 48.0y) and 1055 male, 20–91y (median: 45.5y). Body weight, height, waist circumference, arterial blood pressure, TSH, FT4 and lipids were measured. Known hypothyroidism was reported by 53 subjects (2.2%) and hyperthyroidism by 20 (0.8%). New hypothyroidism was found in 98 (4.1%), [subclinical (3.2%), overt (0.9%)]. New hyperthyroidism was found in 68 (2.9%), [subclinical (2.5%), overt (0.4%)]. New diagnosis of hypothyroidism and hyperthyroidism was entered in 84% and 87% in male subjects and 60% and 65% in the females respectively. Arterial hypertension was present in 40% of the women and in 47% of the men (p<0.001) and was more prevalent in hypothyroidism. Abdominal obesity and dyslipidemia were more prevalent in males and hypothyroid subjects. Arterial hypertension depended on age, gender and lipid status but not on thyroid function. CHD history depended on thyroid function and age. Conclusion: Most cases of thyroid dysfunction were undiagnosed, especially in the males. CV risk factors were more prevalent in the males with thyroid dysfunction a major determinant of CHD, but not hypertension.
Predicting Tunnel Squeezing: A Discussion based on Two Tunnel Projects
Authors: Panthi Krishna Kanta 
Published: November 2013

Tunnel squeezing is a phenomenon, which is frequently confronted while tunneling through Himalayan rock mass. Weak and schistose rocks like mudstone, shale, slate, phyllite, schist, highly schistose mica gneiss and the rock mass of the tectonic fault zones are incapable of sustaining high stresses. A reliable and trustworthy prediction on the extent of squeezing is therefore essential. The reliable prediction results help to make strategy regarding stabilizing measures and optimization of tunnel rock support well in advance. This paper is mainly focused in analyzing the tunnel squeezing that took place in connection with the two tunnel cases; i.e. Kali Gandaki 'A' and Middle Marsyangdi headrace tunnels. The main focus is given to look on the applicability of squeezing analysis using Hoek and Marinos approach in combination with the equation proposed by Panthi for the estimation of rock mass strength for highly schistose rocks of the Himalaya. The measured tunnel convergence (squeezing) and lab tested mechanical properties of the rocks from these two headrace tunnels have been used to verify the applicability of the proposed methods and also the uncertainty analysis approach on squeezing introduced by Panthi.Hydro Nepal; Journal of Water, Energy and EnvironmentVol. 12, 2013, JanuaryPage: 20-25DOI: http://dx.doi.org/10.3126/hn.v12i0.9027Uploaded Date : 10/28/2013
Properties of aluminium coatings produced using manual and robotized flame spraying processes
Authors: Glogović Zlatko , Kožuh Zoran , Kralj Slobodan , Alar Vesna , Stojanović Ivan 
Published: November 2013

Abstract
Aluminium coatings applied using arc or flame spraying processes are frequently employed for protection of steel structures in maritime applications. Results of comparative testing of aluminium coatings produced by manual and robotized flame spraying on steel substrate are reported in the contribution. Particular attention during the investigation of coating properties has been given to the uniformity of coating thickness, adhesion and corrosion resistance. Analysis of the results yielded conclusions on the quality, adhesion and corrosion resistance of the aluminium coating when the coating is applied to the flat steel plate.