bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bidirectional association between type 2 diabetes and irritable bowel syndrome: A large‐scale prospective cohort study
Authors: Zhou Yesheng , Liu Si , Zhang Qian , Zhang Shutian , Wu Shanshan , Zhu Shengtao 
Published: August 2024

AbstractAimTo examine the bidirectional association between type 2 diabetes (T2D) and irritable bowel syndrome (IBS) in a large prospective population cohort.MethodsParticipants free of IBS at baseline in the UK Biobank were included in the analysis of T2D and incident IBS (cohort 1), with 11 140 T2D patients and 413 979 non‐T2D patients. Similarly, those free of T2D at baseline were included in the analysis of IBS and incident T2D (cohort 2), with 21 944 IBS patients and 413 979 non‐IBS patients. Diagnoses of T2D and IBS were based on International Classification of Disease‐10 codes. The Cox proportional hazards model was used to estimate adjusted hazard ratios (HRs).ResultsIn cohort 1, 8984 IBS cases were identified during a median 14.5‐year follow‐up. Compared with non‐T2D, T2D patients had a 39.0% increased risk of incident IBS (HR = 1.39, 95% confidence interval [CI]: 1.23‐1.56, P < .001), with a higher IBS risk in those with higher fasting blood glucose levels (HR = 1.43, 95% CI: 1.19‐1.72, P < .001) or longer T2D duration (HR = 1.47, 95% CI: 1.23‐1.74, P < .001). In cohort 2, 29 563 incident T2D cases were identified. IBS patients had an 18.0% higher risk of developing T2D versus non‐IBS patients (HR = 1.18, 95% CI: 1.12‐1.24, P < .001). A similar excess T2D risk was observed in IBS patients with a duration of either less than 10 years, or of 10 years or longer. Further sensitivity analysis and subgroup analysis indicated consistent findings.ConclusionsT2D and IBS exhibit a bidirectional association, with an increased risk of co‐morbidity. Awareness of this association may improve the prevention and management of both diseases.
Association of Life's Essential 8 with abdominal aortic calcification and mortality among middle‐aged and older individuals
Authors: Ni Gehui , Jia Qinfeng , Li Ying , Cheang Iokfai , Zhu Xu , Zhang Haifeng , Li Xinli 
Published: August 2024

AbstractAimTo assess the association of Life's Essential 8 (LE8) and the presence of abdominal aortic calcification (AAC) with mortality among middle‐aged and older individuals.MethodsParticipants aged older than 40 years were enrolled from the National Health and Nutrition Examination Survey 2013‐2014. AAC was assessed using dual‐energy X‐ray absorptiometry. Mortality data were ascertained through linkage with the National Death Index until 31 December 2019. The LE8 score incorporates eight components: diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose and blood pressure. The total LE8 score, an unweighted average of all components, was categorized into low (0‐49), medium (50‐79) and high (80‐100) scores.ResultsThis study included 2567 individuals, with a mean LE8 score of 67.28 ± 0.48 and an AAC prevalence of 28.28%. Participants with low LE8 scores showed a significantly higher prevalence of AAC (odds ratio = 2.12 [1.12‐4.19]) compared with those with high LE8 scores. Over a median 6‐year follow‐up, there were 222 all‐cause deaths, and 55 cardiovascular deaths occurred. Participants with AAC had an increased risk of all‐cause (hazard ratio [HR] = 2.17 [1.60‐2.95]) and cardiovascular (HR = 2.35 [1.40‐3.93]) mortality. Moreover, individuals with AAC and low or medium LE8 scores exhibited a 137% (HR = 2.37 [1.58‐3.54]) and 119% (HR = 2.19 [1.61‐2.99]) higher risk of all‐cause mortality, as well as a 224% (HR = 3.24 [1.73‐6.04]) and 125% (HR = 2.25 [1.24‐4.09]) increased risk of cardiovascular mortality, respectively.ConclusionsThe LE8 score correlates with AAC prevalence in middle‐aged and older individuals and serves as a valuable tool for evaluating the risk of all‐cause and cardiovascular mortality in individuals with AAC.
Dynamic optical coherence tomography for imaging acute wound healing
Authors: Schuh Sandra , Berger Maximilian , Schiele Stefan , Rubeck Anna , Müller Gernot , González Jennifer Jahel Vélez , Holmes Jon , Welzel Julia 
Published: August 2024

AbstractThe aim of this study was to investigate acute wound healing with dynamic optical coherence tomography (D‐OCT). From 22 patients with 23 split skin graft donor sites, vessels at four wound edges, the wound bed, and adjacent and unaffected skin of the contralateral leg were measured by D‐OCT at six time points from surgery to 4 weeks of healing. Changes in vessel orientation, density, diameter, morphology and pattern in horizontal, vertical and 3D images were analysed for wound healing and re‐epithelialization. At 300 μm depth, there were significant differences of blobs and serpiginous vessels between normal and wounded skin. The wound had significantly more vertically oriented vessels, a higher degree of branching, vessel density and diameter compared with healthy skin. 3D images showed increased angiogenesis from healthy skin towards the wound centre, significantly higher vessel density at the wound than at normal skin and the highest at the interface. During wound healing blobs, coils and serpiginous vessels occurred significantly more frequently in lesional than healthy skin. Vessel density was greatest at the beginning, decreased and then increased by 4 weeks post‐surgery. D‐OCT helps to evaluate acute wound healing by visualizing and quantifying blood vessel growth in addition to re‐epithelialization.
First report of blast disease on Oplismenopsis najada caused by Pyricularia oryzae in Argentina
Authors: Bastida Lisandro Martín , Gutierrez Susana Alejandra , Bich Gustavo Angel , Castrillo María Lorena , Quiroga Joaquín Augusto , Carmona Marcelo Aníbal , Cardozo Téllez Lourdes , Chávez Alice Rocío 
Published: August 2024

AbstractIn 2022, Pyricularia blast‐like symptoms were observed in Oplismenopsis najada plants in Argentina. P. oryzae was identified based on its cultural and morphometric characteristics, nucleotide sequencing of ITS1‐5.8S‐ITS2 amplicons, complemented with phylogenetic analyses, and PCR with Pot2 marker. Koch's postulates were confirmed on O. najada and the Guri INTA CL variety of Oryza sativa. The obtained sequences were deposited in GenBank (ITS: OR741772). The PCR reaction amplified the Pot2 marker, confirming that it is P. oryzae. To our best knowledge, this is the first report of O. najada as new host of P. oryzae worldwide.
Declarative and Automatized Phonological Vocabulary Knowledge: Recognition, Recall, Lexicosemantic Judgment, and Listening‐Focused Employability of Second Language Words
Authors: Uchihara Takumi , Saito Kazuya , Kurokawa Satsuki , Takizawa Kotaro , Suzukida Yui 
Published: August 2024

AbstractThis study revisits the roles of different aspects of phonological vocabulary knowledge in second language (L2) listening. Japanese learners of English (n = 114) completed the TOEIC Listening test and three phonological vocabulary tests assessing (a) ability to recognize the meanings of aural forms (meaning recognition), (b) ability to recall the meanings of aural forms (meaning recall), and (c) ability to spontaneously judge the appropriate use of word meanings in sentential contexts (lexicosemantic judgment task [LJT]). Among the three measures, the LJT best predicted the participants’ ability to access the target words during real‐life L2 listening comprehension of monologues and conversations (measured via TOEIC). Structural equation modeling demonstrated that the LJT was distinct from both meaning recognition and recall and revealed their different associations with listening comprehension scores. In line with the skill acquisition theory, we propose that the LJT reflects automatized knowledge, whereas meaning recognition and recall represent declarative knowledge.
Gender inequalities in oral medicine and pathology research: Temporal trends of two decades
Authors: Braz Gabriel Lima , Figueiredo Amanda dos Santos , Soares Alini Cardoso , Garcia Francielli Fernandez , Calderipe Camila Barcellos , Chisini Luiz Alexandre , Vasconcelos Ana Carolina Uchoa 
Published: August 2024

AbstractObjectivesTo analyze gender inequities and trends in the authorship of articles published in high‐impact factor journals of the field of Oral Medicine and Pathology.MethodsThe gender and country of first and last authors were retrieved from original articles published between 2000 and 2022. Poisson regression models and classification and regression tree (CART) analysis were performed.ResultsA total of 6595 studies were analyzed for first authorship, and 6627 for last authorship. Only 39.2% (CI 95% 38.0–40.3) of the first authors and 24.1% (CI 95% 23.1–25.1) of the last authors were females. Females consistently faced underrepresentation throughout the 23‐year evaluation. The only region where female first authors are not a minority is Latin America. Having a female as the last author increased the prevalence of females in the first author position by 42% (PR = 1.42, CI 95% [1.30–1.54]). The most important discriminant variable by CART was the first author region.ConclusionAlthough a slight decrease in underrepresentation was noted over the period, after 2020, the gender gap tended to widen for both first and last authors. It is crucial to implement measures aimed at attracting, retaining, and advancing women in the field of science, while also actively monitoring advancements toward achieving gender equity.
Rutin alleviates psoriasis‐related inflammation in keratinocytes by regulating the JAK2/STAT3 signaling
Authors: Wu Panhong , Liu Yonghui , Zhai Hanxue , Wu Xiaohan , Liu Aimin 
Published: August 2024

AbstractBackgroundPsoriasis is a chronic inflammatory skin disease that can cause systemic inflammation in various organs. Rutin has been suggested to fight psoriasis, but the signaling pathways by which it works need to be explored.Materials and methodsHaCaT cells co‐stimulated with interleukin (IL)‐17, IL‐22, tumor necrosis factor‐alpha (TNF‐α), IL‐1α, and oncostatin M (M5) were used as an in vitro cell model of psoriasis. The proliferation and viability of HaCaT cells were determined by 5‐ethynyl‐2′‐deoxyuridine and cell counting assays. Relative mRNA levels of IL‐6, TNF‐α, chemokines (CXCL1 and CXCL2), and anti‐microbial peptides (S100A7 and S100A8) were detected by reverse transcriptase‐quantitative PCR. Release of IL‐6 and TNF‐α from HaCaT cells was measured by enzyme‐linked immunosorbent assay. Keratin1, Keratin5, p‐JAK2, and p‐STAT3 protein levels were estimated with western blotting. Molecular docking predicted binding sites for Rutin and STAT3.ResultsRutin treatment undercut M5‐urged viability increase and proliferation boost in HaCaT cells. Moreover, M5 stimulation mediated upregulation of IL‐6, TNF‐α, CXCL1, CXCL2, S100A7, and S100A8 was partially reversed after Rutin treatment. In addition, M5 stimulation induced downregulation of Keratin1 and Keratin5 proteins as well as upregulation of p‐JAK2 and p‐STAT3 proteins were attenuated in response to Rutin treatment, manifesting that Rutin treatment inhibited M5‐promoted aberrant differentiation and impaired M5‐mediated activation of the JAK2/STAT3 signaling in HaCaT cells. Molecular docking discovered that residues GLN326 and ASP334 in STAT3 might bind to Rutin.ConclusionRutin treatment blocked the JAK2/STAT3 signaling, thus attenuating psoriasis‐related inflammation and anomalous differentiation in keratinocytes.
Epidermal and dermal hydration in relation to skin color parameters
Authors: Mayrovitz Harvey N. , Aoki Kawaiola , Deehan Emily , Ruppe Marissa 
Published: August 2024

AbstractBackgroundOur goal was to investigate linkages between skin color parameters and skin hydration. Since most prior studies focused on stratum corneum hydration, we focused on epidermal and dermal hydration in relation to skin color parameters in both sexes.Materials and MethodsThirty adults (16 female) with an age ± SD of 24.3 ± 0.6 years participated. Three sites on both volar forearms were evaluated for melanin index (MI), erythema index (EI), Individual Typology Angle (ITA), tissue dielectric constant (TDC) values to depths of 0.5 mm (TDC0.5) and 2.5 mm (TDC2.5), and Fitzpatrick skin type (FST).ResultsMI and EI were highly correlated (r = 0.800, p < 0.001) with maximum differences in MI and ITA along the arm of 3% and 6.3% with no difference between arms. Male MI was greater than females (p < 0.01). Male TDC2.5 was 36.1 ± 5.4 and correlated with EI (r = 0.231, p = 0.035). Contrastingly, female TDC25 was 28.5 ± 3.6 with no correlation with EI but was correlated with MI (r = −0.301, p = 0.003). These differential patterns held true for TDC0.5. For both sexes, FST and ITA were highly correlated (r = −0.756, p < 0.001).ConclusionsThe findings revealed several correlations between skin color parameters and hydration that differed between males in females in some cases. The observed correlations may indicate that melanin may differentially impact water‐holding capacity between sexes and provides a future research target. Further, these initial findings also may hold significance for dermatological assessments and the customization of skincare treatments tailored to individual skin types and demographics.
Evolution and post‐transcriptional regulation insights of m6A writers, erasers, and readers in plant epitranscriptome
Authors: Zhang Jun , Wu Lin , Mu Lele , Wang Yuhua , Zhao Mengna , Wang Huiyuan , Li Xiangrong , Zhao Liangzhen , Lin Chentao , Zhang Hangxiao , Gu Lianfeng 
Published: August 2024

SUMMARYAs a dynamic and reversible post‐transcriptional marker, N6‐methyladenosine (m6A) plays an important role in the regulation of biological functions, which are mediated by m6A pathway components including writers (MT‐A70, FIP37, VIR and HAKAI family), erasers (ALKBH family) and readers (YTH family). There is an urgent need for a comprehensive analysis of m6A pathway components across species at evolutionary levels. In this study, we identified 4062 m6A pathway components from 154 plant species including green algae, utilizing large‐scale phylogenetic to explore their origin and evolution. We discovered that the copy number of writers was conserved among different plant lineages, with notable expansions in the ALKBH and YTH families. Synteny network analysis revealed conserved genomic contexts and lineage‐specific transpositions. Furthermore, we used Direct RNA Sequencing (DRS) to reveal the Poly(A) length (PAL) and m6A ratio profiles in six angiosperms species, with a particular focus on the m6A pathway components. The ECT1/2‐Poeaece4 sub‐branches (YTH family) with unique genomic contexts exhibited significantly higher expression level than genes of other ECT1/2 poeaece sub‐branches (ECT1/2‐Poeaece1‐3), accompanied by lower m6A modification and PAL. Besides, conserved m6A sites distributed in CDS and 3′UTR were detected in the ECT1/2‐Poaceae4, and the dual‐luciferase assay further demonstrated that these conserved m6A sites in the 3′UTR negatively regulated the expression of Firefly luciferase (LUC) gene. Finally, we developed transcription factor regulatory networks for m6A pathway components, using yeast one‐hybrid assay demonstrated that PheBPC1 could interact with the PheECT1/2‐5 promoter. Overall, this study presents a comprehensive evolutionary and functional analysis of m6A pathway components and their modifications in plants, providing a valuable resource for future functional analysis in this field.
A Qualitative Exploration of Coaches’ Perceived Challenges and Recommendations Relating to Social Justice in Canadian High School Sport
Authors: Bishop Evan , Camiré Martin 
Published: August 2024

Sport can at once promote social justice and reinforce systemic inequities. Considering the influence coaches have on athlete development, research related to coaches’ perspectives on social justice issues is warranted. The purpose of the study was to explore Canadian high school sport coaches’ attitudes towards social justice. An online survey saw 392 coaches respond to six open-ended questions on perceived challenges (three questions; n = 989 responses) and recommendations (three questions; n = 724 responses) related to social justice within their teams, schools, and school boards. A content analysis led to coaches’ responses being classified into three groups: (a) high school sport faces social justice issues (57.38%), (b) no social justice challenges and/or recommendations to share (39.34%), and (c) urgency regarding social justice issues is overblown (3.28%). A reflexive thematic analysis, guided by the critical positive youth development framework, was used to develop several overarching themes, highlighting persistent inequities, a lack of involvement from school boards, missed/ignored social justice issues, and a small group of antisocial justice coaches within the Canadian high school sport system. Considerations for coach education programmes and future research are discussed.
Impact of Physical Educators’ Appearance and Sex on Elementary School Students’ Learning and Perceptions of the Teachers
Authors: Chen YuChun , Myers Brian 
Published: August 2024

Purpose: This research examined the impact of two physical educators’ appearance and sex on elementary school students’ learning and teacher perceptions. Method: Four videos consisting of female informal appearance, female formal appearance, male informal appearance, and male formal appearance were created. A content examination and a perception questionnaire were used to collect data. Factorial analyses of variance were conducted to identify significant main effects or interactions on the examination (i.e., total score, techniques, strategies) and teacher perceptions (i.e., likability, competence, role modeling). Results: Data revealed no significant main effect for teacher appearance or sex on the six variables. A significant interaction effect on the technique-related question was identified; the participants scored higher when the female teacher dressed formally than when she dressed informally. However, the participants performed better when the male teacher dressed informally than when he dressed formally. Discussion/Conclusion: Future research investigating the “true” formal and informal appearance is warranted.
Supplemental Material: Desertic siliciclastic stromatolites in the Upper Jurassic Guará Formation from southwestern Gondwana: Trapping and binding in a non-marine setting
Authors: Angonese Bruno S. , al. et 
Published: August 2024

<p>In-depth facies description and interpretation, additional macroscopic and microscopic pictures, and a stratigraphic correlation section of outcrop 2. </p>
Fatigue analysis of selective laser melting Inconel 718 and the mechanism of ductile–brittle continuous alternating steps during fatigue process
Authors: Xue Suqi , Yang Shanglei , Li Yanlei , Fang Yu 
Published: August 2024

In this paper, Inconel 718 powber fabricated by selective laser melting were studied to explore the mechanical characteristics and microstructures. The results of microstructure show that the material exhibits the columnar, honeycomb, and mixed crystal structures. The microhardness is very uniform, with a average value of 317 HV. Tensile test shows the ultimate tensile strength of 785Mpa, elongation of 4.93%, which is high stress brittle fracture. The fatigue strength of 180 MPa was obtained from the fatigue test. The fatigue life was sensitive to the effect of stress. In the scanning electron microscope observation, small crack propagation was found in the fracture, and a large number of step-like fracture characteristics of repeated transformation of toughness and brittleness were found. The mechanism analysis of the step-like ductile–brittle fracture is carried out, which is divided into four stages. Mathematically analyzing the tough-brittle fracture of the step type, where the crack is subjected to both the stress field around the pore and the stress field at the crack tip on the way to extension, a stress field model for crack propagation around the pore and a fracture toughness formula for transverse and longitudinal propagation of tough-brittle steps applicable to this paper are proposed.
A Phase 1 First-in-Human Study of the MCL-1 Inhibitor AZD5991 in Patients with Relapsed/Refractory Hematologic Malignancies
Authors: Desai Pinkal , Lonial Sagar , Cashen Amanda , Kamdar Manali , Flinn Ian , O’Brien Susan , Garcia Jacqueline S. , Korde Neha , Moslehi Javid , Wey Margaret , Cheung Patricia , Sharma Shringi , Olabode Damilola , Chen Hong , Ali Syed Firasath , Liu Mary , Saeh Jamal , Andrade-Campos Marcio , Kadia Tapan M. , Blachly James S. 
Published: August 2024

Abstract

Purpose:
AZD5991, a human MCL-1 inhibitor, was assessed for safety, tolerability, pharmacokinetics, and antitumor activity as monotherapy and in combination with venetoclax in patients with relapsed or refractory hematologic malignancies.

Patients and Methods:
In the monotherapy cohort (n = 61), patients with hematologic malignancies received AZD5991 intravenously in escalating doses either once or twice weekly, following intrapatient dose escalation, during a 3-week cycle. In the combination cohort (n = 17), patients with acute myeloid leukemia and myelodysplastic syndrome received escalating doses of AZD5991 and venetoclax during either a 3- or 4-week cycle. Primary objectives were safety and maximum tolerated dose; secondary objectives included plasma pharmacokinetics and antitumor activity.

Results:
The most common (≥30%) adverse events were diarrhea (59.0%), nausea (55.1%), and vomiting (47.4%). Four deaths occurred because of adverse events: cardiac arrest, sepsis, tumor lysis syndrome, and acute respiratory failure; only tumor lysis syndrome was related to AZD5991. Dose-limiting toxicities occurred in five patients. Three patients with myelodysplastic syndrome achieved an objective response: one marrow complete remission without hematologic improvement, one partial remission with AZD5991 monotherapy, and one marrow complete remission with AZD5991 + venetoclax. Asymptomatic elevations of troponin I or T were observed in eight (10.3%) patients. Post hoc retrospective analysis revealed elevated troponin T in 14/31 patients before any AZD5991 dose and in 54/65 patients after any AZD5991 dose at or after Cycle 1. No associations were found between elevated troponin and cardiovascular risk factors.

Conclusions:
Treatment with AZD5991 was associated with high incidence of laboratory troponin elevation and a low overall response rate.