bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evaluation and Correlation of Leptin in Gingival Crevicular Fluid and Serum in Health, Gingivitis and Periodontitis
Authors: Vadvadgi Vinay , Padmawar Neeta 
Published: December 2012

ABSTRACT

Background and objective
Plasma leptin is associated in patients with inflammatory diseases. A high concentration of leptin is associated with healthy gingival tissue. The purpose of this study was to assess the concentration of human leptin in gingival crevicular fluid (GCF) and serum within healthy and diseased gingiva, further to explore the possibility of using the levels of leptin in GCF and serum as a biochemical marker of periodontal disease progression.

Materials and methods
Ninety subjects were selected with age (30-39 years) and sex (15 males and 15 females) matched, to eliminate age and sex as confounders. The subjects were divided into three groups consisting of 30 subjects in each group based on the clinical and radiological parameters; healthy (group I), gingivitis (group II), periodontitis (group III), from whom the GCF samples were collected with Periopaper GCF collection strips (Proflow, Amityville, NY, USA) for 30 seconds and blood samples with 20-gauge needle syringe respectively. Leptin concentration was determined from individual GCF and serum samples by enzyme-linked immunosorbent assay (ELISA).

Results
The highest mean leptin concentration in GCF was observed in group I (2,664.30 pg/ml ± 324.73) and least mean leptin concentration was obtained in group III (1,309.43 pg/ml ± 202.45). The mean concentration of group II (1,639.43 pg/ml ± 344.46) was intermediate between the highest and lowest values. In contrast, the highest mean leptin concentration in serum was obtained for group III (12,086.57 pg/ml ± 1,698.23) and least mean leptin concentration was obtained for group I (8,715.09 pg/ml ± 1,649.19). The mean concentration of the group II (10,694.01 pg/ml ± 1,777.72) were intermediate between the highest and lowest values.

Conclusion
The results indicated a statistically significant decrease in the GCF leptin concentration and increase in serum leptin concentration as the periodontal disease progressed.

How to cite this article
Vadvadgi VH, Saini R, Padmawar N. An Evaluation and Correlation of Leptin in Gingival Crevicular Fluid and Serum in Health, Gingivitis and Periodontitis. Int J Experiment Dent Sci 2012;1(2):93-97.
Ectopic Meningioma in the Maxillary Alveolar Ridge: Report of a Case with a Review of the Literature
Authors: Simsek Hasan Onur , Komerik Nurgul 
Published: December 2012

ABSTRACTAimMeningioma is a benign intracranial tumor. Occurrence of ectopic meningioma in maxillary alveolar ridge is very rare. Our aim is to add another case of ectopic meningioma in the maxillary alveolar ridge to the literature.BackgroundMeningioma is a benign tumor that originates from meningocytes found in arachnoid villous structures of the meninges. The tumor is rarely seen in extracranial locations from the oral cavity.Case descriptionWe report on a 51-year-old edentulous woman with an ectopic meningioma on the right maxillary alveolar ridge. The patient had complained of dull pain and discharge from the right maxillary alveolar region. On clinical examination, we observed a lobulated lesion 2 × 2 cm in size. Radiographic examination showed ill-defined radiolucency with irregular radiopaque areas. We also noted oroantral communication from the root of the lesion into to the maxillary sinus with bony destruction. We closed the oroantral communication by a buccal advancement flap. The histopathological diagnosis of the specimen was transitional type grade I meningioma. The patient's 5-year follow-up was uneventful.ConclusionThe histological subtype of the meningioma dictates the mode of surgery. Hence, resection is not considered the treatment of choice for grade I lesions. It is important to keep in mind that meningioma is the differential diagnosis of the intraosseous mandible tumors.Clinical SignificanceEctopic meningioma is very rare. Meningioma should be considered as a differential diagnosis in clinical lesion. In the literature review, this is the fifth case report and review of the literature.How to cite this articleSimsek HO, Komerik N. Ectopic Meningioma in the Maxillary Alveolar Ridge: Report of a Case with a Review of the Literature. Int J Experiment Dent Sci 2012;1(2):98-101.
Primary Manifestation of Sarcoidosis Involving the Gingivae
Authors: Saylor Catherine , Beaini Nabil , Rokos James , Satheesh Keerthana , Cobb Charles 
Published: December 2012

ABSTRACTSarcoidois of the gingiva is rarely the primary manifestation of the disease. The following case presentation highlights clinical signs and symptoms that are not uncommon or unusual except for the anatomical location of the initial expression. Appropriate treatment must be based on a definitive diagnosis which, in turn, requires a biopsy for histologic analysis.How to cite this articleSaylor C, Beaini N, Rokos J, Satheesh K, Cobb C. Primary Manifestation of Sarcoidosis Involving the Gingivae. Int J Experiment Dent Sci 2012;1(2):102-105.
Diagnosis and Treatment of Inflammatory Root Resorption by Intentional Reimplantation
Authors: Bogra Poonam , Saini Suresh Kumar , Saini Amita 
Published: December 2012

ABSTRACTExternal root resorption is a lytic process occurring in the cementum or cementum and dentin of the roots of teeth. It is frequently caused by trauma. Such cases are often difficult to diagnose especially if lesion is on buccal or lingual side, and at times may be difficult to treat using conventional root canal treatment, with extraction being left the only alternative. This article describes the diagnosis and treatment of a case of inflammatory resorption of palatal wall of palatal root of maxillary left first molar by intentional reimplantation. The provisional diagnosis was made from clinical and radiographic observations. The treatment consisted of intentional reimplantation. After extraction it was found that palatal wall of palatal root had been resorbed from furcation till apex. After the resection of the palatal root at the point of resorption, tooth was obturated, reimplanted and splinted. This tooth is serving well since 5 years.How to cite this articleSaini SK, Bogra P, Saini A. Diagnosis and Treatment of Inflammatory Root Resorption by Intentional Reimplantation. Int J Experiment Dent Sci 2012;1(2):106-109.
Unusual Presentation of Foreign Body in a Pediatric Patient
Authors: Awana Meenakshi 
Published: December 2012

ABSTRACT
Missed foreign bodies are one of the leading causes of malpractice claims made against emergency physicians. Foreign bodies in the lip are not common. Here, a case of a child presenting with tooth fragment embedded in the lower lip after a fall is being reported. Accurate diagnosis was made by palpation and radiographic evaluation. The foreign body was removed surgically under local anesthesia with prompt recovery and esthetics was preserved. The patient was taken up for root canal treatment. It is essential to look for foreign bodies embedded in soft tissue particularly in children after a fall, which if overlooked can have significant complications.

How to cite this article
Talwar M, Awana M. Unusual Presentation of Foreign Body in a Pediatric Patient. Int J Experiment Dent Sci 2012;1(2):110-112.
ISW for the Treatment of Facial Asymmetry Crossbite Case with Upper Right Lateral Incisor Missing
Authors: SUN Chia-bin , YU Jian-hong 
Published: December 2012

ABSTRACT
Class III malocclusion with facial asymmetry is difficult to treat with orthodontic treatment without surgery. Skeletal class III malocclusion can be treated with surgery or orthodontic treatment by camouflage. Functional class III malocclusion can be treated perfectly by orthodontic treatment, using the intermaxillary elastics (IME) to correct the jaw relation. Differentially, diagnosing a class III case is important before deciding the treatment plan. We must understand the type of class III malocclusion and then we can make the best choice for the patient. This article reports the treatment of adult class III malocclusion by the improved superelastic TiNi alloy wire (ISW). Using the ISW crossbite arch, coil springs and IME, adequate overbite and overjet were achieved and better facial symmetry was also improved.

How to cite this article
SUN Cb, YU Jh. ISW for the Treatment of Facial Asymmetry Crossbite Case with Upper Right Lateral Incisor Missing. Int J Experiment Dent Sci 2012;1(2): 113-117.

Source of support
This work was supported by China Medical University and Medical Center, Taichung City, Taiwan (Grant number: CMU97-080 (2008) to JH YU).
Chlorine Dioxide: A Potential Mouth Rinse for Oral Health
Authors: Mani Shubangi 
Published: December 2012

ABSTRACT
The current global and regional patterns of oral disease largely reflect distinct risk profiles across countries, related to living conditions, lifestyles and the implementation of preventive oral health systems. Periodontitis has been proposed as having an etiological or modulating role in cardiovascular diseases, diabetes, respiratory disease, adverse pregnancy outcome and other systemic diseases. Chlorine dioxide when stabilized in water and used at low concentration effectively neutralizes volatile sulfur compounds in the oral cavity. This compound has the ability to effectively clean oral tissues on a daily basis without causing harmful side effects.

How to cite this article
Mani S, Mani A, Saini R. Chlorine Dioxide: A Potential Mouth Rinse for Oral Health. Int J Experiment Dent Sci 2012;1(2):118-119.
Contemporaneous Severity of Symptoms and Functioning Reflected by Variations in Reporting Doctor‐Diagnosed Osteoarthritis
Authors: Peeters Geeske , Parkinson Lynne , Badley Elizabeth , Jones Mark , Brown Wendy J. , Dobson Annette J. , Mishra Gita D. 
Published: December 2012

ObjectiveOsteoarthritis (OA) is acknowledged as an enduring condition; however, in epidemiologic studies, half of the participants who report having OA at one time may report not having it at a subsequent time. The aim of this study was to examine whether variations in reporting doctor‐diagnosed OA reflected concurrent fluctuations in indicators of disease severity in middle‐aged women.MethodsData were from 7,623 participants (ages 50–55 years in 2001) in the Australian Longitudinal Study on Women's Health. Based on self‐report of doctor‐diagnosed OA at surveys in 2001, 2004, 2007, and 2010, the participants were classified according to pattern of OA reporting (e.g., 0‐0‐0‐0 = “no” on all surveys, 0‐1‐0‐1 = “no‐yes‐no‐yes”). Indicators of disease severity included frequency of joint pain/stiffness, use of antiinflammatory medications, and physical functioning assessed with the Short Form 36. Bar graphs were used to show concurrent variations in OA and markers, and associations were examined using log‐linear models.ResultsIn this sample, 46% reported having OA on at least one survey, with half of these cases reporting not having OA at a later survey. The odds of reporting joint pain/stiffness often (odds ratio [OR] 7.26, 95% confidence interval [95% CI] 7.06–7.47) and taking antiinflammatory drugs (OR 4.44, 95% CI 2.37–8.33) were higher and physical functioning scores were lower (OR 3.75, 95% CI 3.56–3.95) when participants reported having OA.ConclusionVariations in reporting OA coincided with episodic fluctuations in symptoms and functioning. Inconsistent reporting of OA could therefore reflect the presence of symptoms rather than reporting error and should be considered in longitudinal studies.
Association of Diabetes Mellitus With the Risk of Developing Adhesive Capsulitis of the Shoulder: A Longitudinal Population‐Based Followup Study
Authors: Huang Ya‐Ping , Fann Ching‐Yuan , Chiu Yueh‐Hsia , Yen Ming‐Fang , Chen Li‐Sheng , Chen Hsiu‐Hsi , Pan Shin‐Liang 
Published: December 2012

ObjectiveAlthough it has been suggested that diabetes mellitus (DM) is a risk factor for developing adhesive capsulitis of the shoulder (ACS), data on the temporal association between these 2 conditions are sparse. The purpose of this population‐based age‐ and sex‐matched cohort study was to investigate the risk of developing ACS in patients with newly diagnosed DM.MethodsA total of 78,827 subjects with at least 2 ambulatory care visits with a principal diagnosis of DM in 2001 were recruited for the DM group. The non‐DM group comprised 236,481 age‐ and sex‐matched randomly sampled subjects without DM. The 3‐year cumulative risk of ACS was calculated using the Kaplan‐Meier method. A Cox proportional hazards regression model was used to estimate the crude and adjusted hazard ratio (HR) of developing ACS.ResultsDuring a 3‐year followup period, 946 subjects (1.20%) in the DM group and 2,254 subjects (0.95%) in the non‐DM group developed ACS. The crude HR of developing ACS for the DM group compared to the non‐DM group was 1.333 (95% confidence interval [95% CI] 1.236–1.439, P < 0.0001), whereas the adjusted HR was 1.321 (95% CI 1.224–1.425, P < 0.0001) after adjustment for age, sex, and dyslipidemia.ConclusionThis longitudinal population‐based followup study showed that there is a significantly increased risk of developing ACS after developing DM.
Development of optically transparent ZnS/poly(vinylpyrrolidone) nanocomposite films with high refractive indices and high Abbe numbers
Authors: Zhang Quanyuan , Goh Eunice Shing Mei , Beuerman Roger , Judeh Zaher , Chan‐Park Mary B. , Chen Tupei , Xu Rong 
Published: December 2012

AbstractA series of optically transparent ZnS‐poly(vinylpyrrolidone) (PVP) nanocomposite films with high refractive indices and high Abbe numbers have been prepared. Mercaptoethanol (ME) capped ZnS nanoparticles (NPs) were introduced into the PVP polymer matrix via simple blending with high nanophase contents. ME‐ZnS NPs of around 3 nm were prepared from zinc acetate and thiourea precursors in N,N‐dimethylformamide using ME as a capping agent. Transparent nanocomposite films with high refractive indices and high Abbe numbers can be easily prepared by a conventional film casting method. TGA results indicated that the ZnS/PVP nanocomposite films exhibit good thermal stability and the measured contents of ZnS NPs in the films agree well with the theoretical values. The refractive indices and the Abbe numbers of the ZnS/PVP nanocomposite films range from 1.5061 to 1.7523 and 55.6 to 20.4 with the content of ME‐ZnS NPs varied between 0 and 80 wt %, respectively. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Development of a Hypersensitive Periodate‐Cleavable Amino Acid that is Methionine‐ and Disulfide‐Compatible and its Application in MHC Exchange Reagents for T Cell Characterisation
Authors: Amore Alessia , Wals Kim , Koekoek Evelyn , Hoppes Rieuwert , Toebes Mireille , Schumacher Ton N. M. , Rodenko Boris , Ovaa Huib 
Published: December 2012

AbstractIncorporation of cleavable linkers into peptides and proteins is of particular value in the study of biological processes. Here we describe the synthesis of a cleavable linker that is hypersensitive to oxidative cleavage as the result of the periodate reactivity of a vicinal amino alcohol moiety. Two strategies directed towards the synthesis of a building block suitable for solid‐phase peptide synthesis were developed: a chemoenzymatic route, involving L‐threonine aldolase, and an enantioselective chemical route; these led to α,γ‐diamino‐β‐hydroxybutanoic acids in diastereoisomerically mixed and enantiopure forms, respectively. Incorporation of the 1,2‐amino alcohol linker into the backbone of a peptide generated a conditional peptide that was rapidly cleaved at very low concentrations of sodium periodate. This cleavable peptide ligand was applied in the generation of MHC exchange reagents for the detection of antigen‐specific T cells in peripheral blood cells. The extremely low concentration of periodate required to trigger MHC peptide exchange allowed the co‐oxidation of methionine and disulfide residues to be avoided. Conditional MHC reagents hypersensitive to periodate can now be applied without limitations when UV irradiation is undesired or less practical.
Diagnostic assays for identification of anaplastic lymphoma kinase‐positive non–small cell lung cancer
Authors: Weickhardt Andrew J. , Aisner Dara L. , Franklin Wilbur A. , Varella‐Garcia Marileila , Doebele Robert C. , Camidge D. Ross 
Published: December 2012

AbstractIn series dominated by adenocarcinoma histology, approximately 5% of non–small cell lung cancers (NSCLCs) harbor an anaplastic lymphoma kinase (ALK) gene rearrangement. Crizotinib, a tyrosine kinase inhibitor with significant activity against ALK, has demonstrated high response rates and prolonged progression‐free survival in ALK‐positive patients enrolled in phase 1/2 clinical trials. In 2011, crizotinib received accelerated approval from the US Food and Drug Administration (FDA) for the treatment of proven ALK‐positive NSCLC using an FDA‐approved diagnostic test. Currently, only break‐apart fluorescence in situ hybridization testing is FDA approved as a companion diagnostic for crizotinib; however, many other assays are available or in development. In the current review, the authors summarize the diagnostic tests available, or likely to become available, that could be used to identify patients with ALK‐positive NSCLC, highlighting the pros and cons of each. Cancer 2013. © 2012 American Cancer Society.
Finding near‐perfect parameters for hardware and code optimizations with automatic multi‐objective design space explorations
Authors: Jahr Ralf , Calborean Horia , Vintan Lucian , Ungerer Theo 
Published: December 2012

SummaryIn the design process of computer systems or processor architectures, typically many different parameters are exposed to configure, tune, and optimize every component of a system. For evaluations and before production, it is desirable to know the best setting for all parameters. Processing speed is no longer the only objective that needs to be optimized; power consumption, area, and so on have become very important. Thus, the best configurations have to be found in respect to multiple objectives. In this article, we use a multi‐objective design space exploration tool called Framework for Automatic Design Space Exploration (FADSE) to automatically find near‐optimal configurations in the vast design space of a processor architecture together with a tool for code optimizations and hence evaluate both automatically. As example, we use the Grid ALU Processor (GAP) and its postlink optimizer called GAPtimize, which can apply feedback‐directed and platform‐specific code optimizations. Our results show that FADSE is able to cope with both design spaces. Less than 25% of the maximal reasonable hardware effort for the scalable elements of the GAP is enough to achieve the processor's performance maximum. With a performance reduction tolerance of 10%, the necessary hardware complexity can be further reduced by about two‐thirds. The found high‐quality configurations are analyzed, exhibiting strong relationships between the parameters of the GAP, the distribution of complexity, and the total performance. These performance numbers can be improved by applying code optimizations concurrently to optimizing the hardware parameters. FADSE can find near‐optimal configurations by effectively combining and selecting parameters for hardware and code optimizations in a short time. The maximum observed speedup is 15%. With the use of code optimizations, the maximum possible reduction of the hardware resources, while sustaining the same performance level, is 50%.Copyright © 2012 John Wiley & Sons, Ltd.
ND++ – an extended IPv6 Neighbor Discovery protocol for enhanced stateless address autoconfiguration in MANETs
Authors: Grajzer Monika , Żernicki Tomasz , Głąbowski Mariusz 
Published: December 2012

SUMMARYRecent trends in information and communications technologies are oriented toward the design of the Future Internet and the Internet of Things. While IPv6‐based mobile ad hoc networks (MANETs) are emerging as an important building block of these new technologies, it is necessary to come up with adequate self‐configuration capabilities allowing for seamless and automated configuration of addresses in mobile environment. The mechanisms of stateless address autoconfiguration proposed for IPv6 networks are supposed to automate some configuration steps; however, they would need to be aligned with the requirements imposed by MANET networks. Therefore, in this article, we present Neighbor Discovery ++ – an extended IPv6 Neighbor Discovery protocol for enhanced duplicate address detection in MANETs, which provides increased coverage of network nodes, while minimizing protocol overhead. It exploits efficient flooding mechanism on the basis of the multipoint relay concept, which makes it an interesting approach also for large‐scale networks. Trials performed on the designated real‐world testbed platform indicate that ND++ is a promising solution to support efficient address autoconfiguration in MANETs. Copyright © 2012 John Wiley & Sons, Ltd.
Spin Crossover and Thermochromism of Iron(II) Coordination Compounds with 1,2,4‐Triazoles and Tris(pyrazol‐1‐yl)methanes
Authors: Lavrenova Ludmila G. , Shakirova Olga G. 
Published: December 2012

AbstractWe review herein the synthesis and investigation of iron(II) coordination compounds with 1,2,4‐triazoles or tris(pyrazol‐1‐yl)methanes as ligands. Both groups of complexes demonstrate thermally induced spin crossover accompanied by thermochromism [pink (magenta) ↔ white color change]. Factors that influence the nature and temperature of the spin crossover are discussed.
Glutamate dehydrogenase 1 and SIRT4 regulate glial development
Authors: Komlos Daniel , Mann Kara D. , Zhuo Yue , Ricupero Christopher L. , Hart Ronald P. , Liu Alice Y. ‐C. , Firestein Bonnie L. 
Published: December 2012

AbstractCongenital hyperinsulinism/hyperammonemia (HI/HA) syndrome is caused by an activation mutation of glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme responsible for the reversible interconversion between glutamate and α‐ketoglutarate. The syndrome presents clinically with hyperammonemia, significant episodic hypoglycemia, seizures, and frequent incidences of developmental and learning defects. Clinical research has implicated that although some of the developmental and neurological defects may be attributed to hypoglycemia, some characteristics cannot be ascribed to low glucose and as hyperammonemia is generally mild and asymptomatic, there exists the possibility that altered GDH1 activity within the brain leads to some clinical changes. GDH1 is allosterically regulated by many factors, and has been shown to be inhibited by the ADP‐ribosyltransferase sirtuin 4 (SIRT4), a mitochondrially localized sirtuin. Here we show that SIRT4 is localized to mitochondria within the brain. SIRT4 is highly expressed in glial cells, specifically astrocytes, in the postnatal brain and in radial glia during embryogenesis. Furthermore, SIRT4 protein decreases in expression during development. We show that factors known to allosterically regulate GDH1 alter gliogenesis in CTX8 cells, a novel radial glial cell line. We find that SIRT4 and GDH1 overexpression play antagonistic roles in regulating gliogenesis and that a mutant variant of GDH1 found in HI/HA patients accelerates the development of glia from cultured radial glia cells. © 2012 Wiley Periodicals, Inc.