bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenocarcinoma in the jejunum of a dog: a case report
Authors: Hernández Carlos , Restrepo Rodrigo 
Published: August 2024

Summary
A 10-year-old male Pit-bull was attended for presenting sporadic vomiting and occasional diarrhea. In the last 48 hours the patient had presented multiple vomiting and no oral food was tolerated. During the physical examination an abdominal cranial mass was palpated. Survey radiographs of the abdomen and contrast study with barium sulfate suspension showed an accumulation of a radiopaque material causing an intestinal obstruction pattern. During the surgical exploration, the foreign material was extracted from the jejunum using an enterotomy, but an intramural mass was detected occluding the lumen at this point. A complete bowel resection was performed in the intestinal loop affected by the tumor and an end-to-end anastomosis was performed. The histologic examinations revealed an adenocarcinoma involving the entire intestinal wall. The patient recovered from the surgical procedure and no signs of metastasis have been proved nine months after the surgery.
Resumen
Un perro macho de raza Pitbull de 10 años de edad fue atendido por presentar vómito esporádico en los últimos 2 meses y diarrea ocasional. En las últimas 48 horas el paciente había presentado múltiples vómitos sin tolerar alimentación oral. Al examen clínico se palpó una masa abdominal. Las radiografías abdominales simples y contrastadas con sulfato de bario mostraron un acúmulo de material radiopaco causando un patrón característico de obstrucción intestinal. En la exploración quirúrgica el material causante de la obstrucción que se encontraba en el yeyuno fue retirado mediante enterotomía pero se detectó una masa intraluminal intestinal, por lo que se extrajo el segmento completo y se realizó una enteroanastomosis termino-terminal. El análisis histológico de la masa extraída evidenció un adenocarcinoma envolviendo todo el espesor de la pared intestinal. El paciente se recuperó normalmente y hasta los nueve meses posteriores a la cirugía, no ha aparecido ningún signo de metástasis.
Fisiología de la activación del espermatozoide en peces de agua dulce
Authors: Tabares Carlos J. , Tarazona Ariel M. , Olivera A. Martha 
Published: August 2024

Resumen El principal objetivo de esta revisión fue el estudio de los mecanismos que regulan la movilidad espermática en peces de agua dulce, dada su importancia en el desarrollo de biotecnologías para la conservación de sus gametos, los cuales una vez producidos en el testículo, se capacitan en el conducto espermático donde permanecen inmóviles por factores como el balance iónico, la osmolaridad, el pH o algunas proteínas. En el momento de la liberación de los espermatozoides al medio acuoso, estos son activados por un periodo de tiempo muy corto. En teleósteos de agua dulce, el choque hiposmótico induce cambios de potencial de membrana que conducen a la regulación de canales iónicos de K+ y de Ca2+, seguida por un flujo iónico que desencadena la cascada de activación. Muchas investigaciones se han enfocado en el estudio de la osmolaridad, el balance iónico, el pH y factores dependientes de AMPc y Ca2+; asociados con la activación de la movilidad espermática. De esta forma, los mecanismos fisiológicos de la activación han ganado interés para comprender los procesos por los cuales el espermatozoide adquiere la hipermovilidad para alcanzar el oocito y penetrar el micrópilo antes del cierre del mismo.

Summary This review pretended to study the regulation of spermatozoa motility in freshwater fish, improving biotechnology development focused on gametes preservation, which are produced into the testes. Spermatozoa gets capacitation and stays non- motil due to different factors such as ionic balance, osmolality, pH, and some proteins. After release to the freshwater, the teleost spermatozoa get activated during a very short period, due to hiposmotic shock, producing membrane potential changes, allow regulation of K+ and Ca2+ channels, followed by an ionic flow that trigger the activation. During the last years, investigations focused on the osmolality, ionic balance, pH and AMPc and Ca2+dependent factors; associated to spermatozoa motility activation. In this way, understanding spermatozoa hipermotility process to reach and enter the egg´s micropile before closing, has increased interest in the physiological activation mechanisms.
Piómetra y gestación simultáneos en una perra: reporte de un caso
Authors: Orozco P. Sonia C. , Quiroz Victor H. , Gómez G. Leonardo F. , Villegas Juan P. 
Published: August 2024

Resumen Se expone el caso de una perra Bulldog Inglés que presentaba una gestación aproximada de 36 a 38 días, con secreción sanguinopurulenta por vulva y decaimiento, siendo éstos los únicos hallazgos al examen físico general. Al realizar procedimientos diagnósticos complementarios se evidenció que había productos vivos en un cuerno uterino y el otro estaba ocupado por fluido.
Summary This is the a case report of a 2 year old English bulldog bitch with 36 to 38 days of gestation, which displayed a bloody-purulent vulvar discharge and a lethargic condition, being these the only findings at the physical examination. After performing ancillary tests, fetal viability was determined in one of the uterine horns and the other horn was occupied by fluid.
Disminución de la reproducción, el crecimiento y la sobrevivencia de peces, debido a una alteración en la cantidad y la calidad del agua: reporte de caso
Authors: Botero Aguirre Mónica , Ochoa S. Jorge , Jiménez Héctor A. , Uribe Jaime H. 
Published: August 2024

Resumen
Se presenta el caso de la situación generada en la Estación piscícola, propiedad de La Universidad de Antioquia, en el corregimiento de San José del Nus, municipio de San Roque, a raíz del proceso de eutrofización de la quebrada La Vega que abastece el sistema de producción. La situación encontrada determinaba una reducción en el caudal del agua y un deterioro de la calidad físico-química de la misma, causando una disminución en la reproducción, el crecimiento y la sobrevivencia de los peces. Se estableció un programa de manejo cultural para solucionar el problema, lo que en la actualidad ha llevado a mantener unas condiciones apropiadas, tanto en cantidad como en calidad del recurso hídrico.
Summary
The authors present the problems and solutions given to an eutrophication process observed in La Vega river, at the level of the Aquatic Experimental Station of San Jose del Nus, in the province of Antioquia, Colombia. The river bed became invaded by two pasture species (Brachiaria plantaginea and Brachiaria arrecta), coming from the nearby fields. The process generated low levels of dissolved oxygen, pH changes, and high levels of dissolved carbon dioxide and organic material, among other problems. To alleviate the situation, a plan was established for the immediate, mid and long terms. The plan included recovering vegetable materials from the stream in order to prevent further pasture growth either in the stream, a downstream lake, and a connecting channel. The plan also included reforesting the river sides to eliminate the grass by excluding competition.
Algunos aspectos biológicos y del manejo en cautiverio de la Sabaleta Brycon henni Eigenmann, 1913 (Pisces: Characidae)
Authors: Montoya Andrés F. , Carrillo Lina M. , Olivera A. Martha 
Published: August 2024

Resumen
La sabaleta Brycon henni (Eigenmann, 1913) es un Charácido endémico de Colombia, habita en las cuencas de los ríos Magdalena, San Juan, Dagua y Patía, es catalogada como una especie promisoria para la cría en cautiverio, y para el repoblamiento. Esta especie es importante para la seguridad alimentaria de las poblaciones ribereñas de las zonas que habita. Esta revisión tuvo como objetivo mostrar la información más relevante acerca de la morfología, la distribución, los hábitos alimenticios, la reproducción, el mantenimiento en cautiverio, la citogenética, la ecotoxicología y la diversidad genética de las poblaciones de la sabaleta; se evidencia la carencia de información en aspectos de su biología y cultivo. Se sugieren tópicos fundamentales para la creación de un paquete tecnológico eficaz de cultivo y manejo pesquero de la especie.
Summary
Brycon henni is an endemic characoid from Magdalena, San Juan, Dagua and Patia river basins (Colombia), it is catalogued as a promissory species to culture and to repopulate natural streams; this species is important for riverside populations food safety. In this review we tried to show the most relevant information about morphology, distribution, feeding, reproduction, culture, cytogenetic, ecotoxicology and population genetics of this B. henni, we demonstrated here the lack of biology and culture information. We suggested fundamental topics for culture and fisheries management technological package construction.
Unlocking the power of echocardiography: strategies in risk stratification of patients with PE using echocardiography
Authors: Shahabi Raberi Venus , Jafari Negar , Zadeh Reza Faramarz , Parizad Razieh , Kahourian Ozra 
Published: August 2024

Objectives: Pulmonary embolism (PE) is challenging to diagnose due to nonspecific symptoms. While computed tomography pulmonary angiography (CTPA) is the gold standard, transthoracic echocardiography (TTE) is frequently used first. This study aimed to evaluate the accuracy of TTE findings in predicting the severity of CTPA-confirmed PE.
Methods: This retrospective study in 2023, analyzed 124 patients who underwent CTPA for suspected PE at Seyed Al Shohada Hospital of Urmia, Iran. The Pulmonary Embolism Severity Index (PESI), as a risk stratification tool for pulmonary embolism, was measured in the first hours of hospitalization. TTE was performed 48 hours following hospital admission, with an emphasis on Key TTE parameters, including McConnell’s sign, D-shape septum sign, right ventricular (RV) dimensions, left ventricular dimensions, pulmonary artery (PA) diameter, tricuspid regurgitation gradient (TRG), Tricuspid annular plane systolic excursion (TAPSE) and PA acceleration time (PaACT). Sensitivity, specificity and predictive value were all calculated.
Results: Most patients were women (53.23%) over 60 (38.71%). Several TTE measures showed promise for predicting PE: RV dilation (sensitivity 84%, specificity 77%), PA diameter (84% and 28%), TRG (66% and 58%), and PA acceleration time (92% and 62%). However, McConnell’s sign had low accuracy (area under ROC curve 0.62). Tricuspid annular plane systolic excursion (TAPSE) and PA acceleration time showed the best predictive performance (AUC 0.95-0.92) and can be used as screening tools for life-threatening massive PE.PESI index test, when compared to the gold standard CT scan (which shows lung involvement), does not provide additional valuable information and accurate predictions about the severity of PE.
Conclusions: TAPSE and PaACT showed excellent predictive ability to CTPA-detected PE. RV dilation and PA diameter also showed good predictive capability. Findings support using some TTE indices to screen for PE severity and risk assessment before CTPA when access is limited.
Epidemiology of Human Monkeypox about the 2022 Outbreak: A Narrative Review
Authors: Fakhri-Demeshghieh Aliasghar , Akbarein Hesameddin , Almasi Parsa 
Published: August 2024

Abstract: Human Monkeypox is a zoonotic disease caused by 2 distinct clades of human monkeypox virus (MPXV). MPXV infections can cause several clinical symptoms including fever, skin rash, back pain, and lymphadenopathy in humans. Even though MPXV infections are generally self-limiting, death is possible and fatality due to MPXV infections in humans is 3-6 percent. While the disease is endemic to Africa, its potential to cause outbreaks in other continents has been observed. The natural reservoir of MPXV in Africa and the full host range of the virus are not known, but rodents are suggested to be the reservoirs. The transmission of MPXV occurs via close contact and the prevention strategies include avoiding close contact and post-exposure prophylactic vaccination of people at risk with smallpox vaccines. In this study, the most recent information about the epidemiology of MPXV about the latest research on the 2022 outbreak of MPXV has been reviewed.
"Inspired to be a teacher seriously": An autoethnography of student engagement in a Vietnamese TESOL training programme
Authors: Huynh Huy-Hoang , Pretorius Lynette 
Published: August 2024

TESOL (Teaching English to Speakers of Other Languages) training programmes in Vietnam often emphasise the significant alignment of academic knowledge with practical classroom methods. However, an intricate yet underexplored topic is understanding the dynamic engagement of student teachers in those programmes to investigate the complexities of such alignment. Therefore, this research examines factors influencing student teachers’ in-class engagement following a 120-hour TESOL training programme at an institution in Vietnam. This autoethnographic study analysed a TESOL teacher trainer’s reflections on student teachers’ engagement in the programme, using artefacts in the form of anonymous and open-ended short-text feedback from 30 students across approximately eight months. The reflection and feedback responses were analysed thematically, anchored in a framework emphasising the three facets of in-class engagement, i.e., cognitive, emotional, and behavioural dimensions. Through the analysis, three themes were constructed: (1) theoretical-practical synthesis: how TESOL-related concepts are blended with concrete teaching examples; (2) pedagogical climate: the teacher educator’s critical role in creating a receptive and engaging learning environment; and (3) professional pathway clarity: the student teachers’ understanding of their future roles and trajectories in the TESOL arena. The research’s findings provide TESOL educators with crucial insights into student teachers’ engagement with teaching methods that synthesise both theoretical and practical components. Moreover, the research enriches the academic discourse, underscoring the potential of using the cognitive, emotional, and behavioural engagement triad as a diagnostic tool to understand students’ learning experiences in TESOL training programmes.
An updated method on the injectivity of integral operators related to Riemann Hypothesis
Authors: Adam Dumitru 
Published: August 2024

Abstract

With this paper, a reformulation and improvement of the previous version v3 of [2] and a continuation of [1], we provided a solution for the Alcantara-Bode equivalent formulation ([3]) of the 165 years old Riemann Hypothesis - one of the Clay Inst. \textit{Millennium Problems}.
We consider it to be a solution in the areas of numerical analysis, applied math rather than in the field of number theory as expected but, for someone who needs to have an answer for RH they could find it here.
The Alcantara-Bode equivalence (1993) of the Riemann Hypothesis (RH, 1859) consists in the injectivity of a certain Hilbert-Schmidt integral operator, result obtained from Beurling equivalent formulation of RH (1955).
Both outstanding equivalences reduced RH to a problem dealing with the injectivity of a specific linear bounded operator on a separable Hilbert space.
The scenario behind Theorem 1, a generic result in the area of functional analysis and its associated methods is briefly described below. Given T a linear operator bounded on a separable Hilbert space H without zeros in a dense family of finite dimensional subspaces, its zeros, if any, should be in the difference set between the Hilbert space and the dense set of the union of the subspaces. The methods, the Corollary and the Injectivity Criteria exploit the strict positivity of the operator on the family subspaces as well as the density of the family in H, in order to obtain the sufficient conditions imposed to our operator for its injectivity.

With both methods we proved the Alcantara-Bode equivalence, meaning: the Riemann Hypothesis holds.
Exposure to Organochlorine Pesticides and Obesity in Rural Prediabetic Patients: Associations and Potential Mediation by Multiple Health Indicators
Authors: Mao Zhenxing , Shi Jiayu , Wei Dandan , Ma Cuicui , Geng Jintian , Zhao Mengzhen , Hou Jian , Huo Wenqian , Jing Tao , Chen Zhuo , Huang Shan , Zeng Xin , Wang Chongjian 
Published: August 2024

Abstract

Objective To lessen the burden of diabetes, we explored the relationship between obesity and single and mixed plasma organochlorine pesticides (OCPs) exposure and the mediating roles of 13 health indicators in the correlations mentioned above among 894 rural Chinese adults with prediabetes.Methods The effects of plasma OCPs on obesity and obese anthropometric measurements were assessed by generalized linear regression models for single exposure, and quantile g-computation (QGC) and LASSO regression for mixed exposure. The potential mediating roles of multiple health indicators were explored through mediation analyses.Results We discovered that β-BHC and p,p'-DDE were related to obesity for single exposure. QGC and LASSO demonstrated that OCPs were positively correlated with a higher likelihood of obesity for mixed exposure, with β-BHC being the primary contributor. Mediation analyses found that systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), high-density lipoprotein-Cholesterol (HDL-C), alanine aminotransferase (ALT), and aspartate aminotransferase / alanine aminotransferase (AST/ALT) played significantly mediating roles in the relationship of β-BHC on obesity, with the estimated mediation proportion ranging from 9.0–40.5%.Conclusions Our findings suggest that liver function damage and lipid metabolism disorders may be one of the biological pathways by which OCPs exposure induces obesity risk.
Comparative Analysis of Large Language Models against the NHS 111 Online Triaging for Emergency Ophthalmology
Authors: Khan Shaheryar , Gunasekera Chrishan 
Published: August 2024

Abstract

Background This study presents a comprehensive evaluation of the performance of various language models in generating responses for ophthalmology emergencies and compares their accuracy with the established NHS 111 online Triage system.Methods We included 21 ophthalmology related emergency scenario questions from the 111 triaging algorithm. These questions were based on four different ophthalmology emergency themes as laid out in the NHS 111 algorithm. The responses generated from NHS 111 online, were compared to the different LLM-chatbots responses. We included a range of models including ChatGPT-3.5, Google Bard, Bing Chat, and ChatGPT-4.0. The accuracy of each LLM-chatbot response was compared against the NHS 111 Triage using a two prompt strategy. Answers were graded separately by two different authors as following: −2 graded as “Very poor”, -1 as “Poor”, 0 as “No response”, 1 as “Good”, 2 as “Very good” and 3 graded as “Excellent”.Results Overall score of ≥ 1 graded as “Good” or better was achieved by 93% of responses of all LLMs. This refers to at least part of the answer having correct information and partially matching NHS 111 response, as well as the absence of any wrong information or advice which is potentially harmful to the patient’s health.Conclusions The high accuracy and safety observed in LLM responses support their potential as effective tools for providing timely information and guidance to patients. While further research is warranted to validate these findings in clinical practice, LLMs hold promise in enhancing patient care and healthcare accessibility in the digital age.
Manual Manipulation and Ex Vivo Flexible Ureteroscopic Lithotripsy to Salvage Deceased Donor Kidneys with Renal Stones: A Case Series
Authors: Xiong Lin , Kwan Kristine J.S. , Pan Jian-Yong , Lu Zhen-Quan , Fu Ying-Xin 
Published: August 2024

Abstract

Background:
Nephrolithiasis is a relative contraindication to kidney donation. This study aimed to determine the feasibility and effectiveness of a surgical technique that can salvage a deceased donor kidney with renal stone, which involves manual manipulation of the kidney harvested from a deceased donor combined with flexible ureteroscopic lithotripsy (MM-FURSL)
Case presentation:
A total of 9 kidneys were harvested from 6 deceased patients. The recipients (66.7% female; mean age 43.9 ± 12.2 years) previously received dialysis for a mean duration of 2.6 years before receiving renal transplantation with MM-FURSL. The number of stones in donor kidneys ranged between 1 – 4 (mean max. diameter 15.1 ± 10.6 mm; mean CT value 942.0 ± 106.6 HU). Mean duration of warm and cold ischemia for the donor kidneys were 5 min and 480 ± 108.2 min respectively. The mean total operative duration was 57.0 ± 63.4 min. The first patient that underwent MM-FURSL used a reusable FURS that was found to be damaged intraoperatively. Her operative time and donor cold ischemia duration was the longest. She was the only patient that suffered from acute tubular necrosis (ATN) but creatine levels recovered within 3 weeks. No other complication was observed during a mean follow-up of 11.7 ± 8.2 months.
Conclusion:
MM-FURSL is an effective method to remove renal stones in donor kidneys. Short-term outcomes were favorable, which may make a feasible method to expand the pool of donor kidneys by salvaging donor kidneys with nephrolithiasis. Prolonged cold ischemia may be associated with ATN and should be avoided.
Preoperative MRI features for predicting response to postoperative adjuvant anti-PD-1 therapy in hepatocellular carcinoma
Authors: Peng Zhenwei , He Xiaofang , Zhan Jie , Sun Yukun , Hu Shuifang 
Published: August 2024

Abstract

Biomarkers for predicting survival benefit of postoperative adjuvant anti-PD-1 therapy (PA-PD-1) in hepatocellular carcinoma (HCC) are scare and lack of clinical evidence currently. This study aimed to identify the value of preoperative MRI features for predicting response to PA-PD-1 in HCC. Between 2020 and 2023, 58 patients with PA-PD-1 and 110 without PA-PD-1 were retrospectively included after propensity-score matching. Patients with PA-PD-1 had significantly longer recurrence-free survival (RFS) than those without PA-PD-1 (29.50 versus 10.97 months, p = 0.005). Absence of hypointense halos and irregular rim-like hyper enhancement were identified as independent predictors for RFS. Subgroup analysis indicated that patients with absence of hypointense halos and irregular rim-like hyper enhancement achieved significantly longer RFS after PA-PD-1 compared with those without PA-PD-1. In conclusion, preoperative MRI features of absence of hypointense halos and irregular rim-like hyper enhancement were significantly associated with recurrence and potential predictors for response to PA-PD-1 in HCC.