bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing practice patterns of Gamma Knife versus linear accelerator-based stereotactic radiosurgery for brain metastases in the US
Authors: Park Henry S. , Wang Elyn H. , Rutter Charles E. , Corso Christopher D. , Chiang Veronica L. , Yu James B. 
Published: October 2015

OBJECT
Single-fraction stereotactic radiosurgery (SRS) is a crucial component in the management of limited brain metastases from non-small cell lung cancer (NSCLC). Intracranial SRS has traditionally been delivered using a frame-based Gamma Knife (GK) platform, but stereotactic modifications to the linear accelerator (LINAC) have made an alternative approach possible. In the absence of definitive prospective trials comparing the efficacy and toxicities of treatment between the 2 techniques, nonclinical factors (such as technology accessibility, costs, and efficiency) may play a larger role in determining which radiosurgery system a facility may choose to install. To the authors’ knowledge, this study is the first to investigate national patterns of GK SRS versus LINAC SRS use and to determine which factors may be associated with the adoption of these radiosurgery systems.

METHODS
The National Cancer Data Base was used to identify patients > 18 years old with NSCLC who were treated with single-fraction SRS to the brain between 2003 and 2011. Patients who received “SRS not otherwise specified” or who did not receive a radiotherapy dose within the range of 12–24 Gy were excluded to reduce the potential for misclassification. The chi-square test, t-test, and multivariable logistic regression analysis were used to compare potential demographic, clinicopathologic, and health care system predictors of GK versus LINAC SRS use, when appropriate.

RESULTS
This study included 1780 patients, among whom 1371 (77.0%) received GK SRS and 409 (23.0%) underwent LINAC SRS. Over time, the proportion of patients undergoing LINAC SRS steadily increased, from 3.2% in 2003 to 30.8% in 2011 (p < 0.001). LINAC SRS was adopted more rapidly by community versus academic facilities (overall 29.2% vs 17.2%, p < 0.001). On multivariable analysis, 4 independent predictors of increased LINAC SRS use emerged, including year of diagnosis in 2008–2011 versus 2003–2007 (adjusted OR [AOR] 2.04, 95% CI 1.52–2.73, p < 0.001), community versus academic facility type (AOR 2.04, 95% CI 1.60–2.60, p < 0.001), non-West versus West geographic location (AOR 4.50, 95% CI 2.87–7.09, p < 0.001), and distance from cancer reporting facility of < 20 versus ≥ 20 miles (AOR 1.57, 95% CI 1.21–2.04, p = 0.001).

CONCLUSIONS
GK remains the most commonly used single-fraction SRS modality for NSCLC brain metastases in the US. However, LINAC-based SRS has been rapidly disseminating in the past decade, especially in the community setting. Wide geographic variation persists in the distribution of GK and LINAC SRS cases. Further comparative effectiveness research will be needed to evaluate the impact of these shifts on SRS-related toxicities, local control, and survival, as well as treatment costs and efficiency.
A Study of Multiple Causes of Death in Rheumatoid Arthritis
Authors: Pinheiro Frederico A.G. , Souza Deborah C.C. , Sato Emilia I. 
Published: October 2015

Objective.To evaluate rheumatoid arthritis (RA)–related mortality in the state of São Paulo (Brazil).Methods.Data from all death certificates (DC) from 1996 to 2010 were analyzed using a multiple cause-of-death method. We compared the results from 2 subperiods (1996–2000 and 2006–2010).Results.We found 3955 DC related to RA — 27.6% with RA as the underlying cause of death (UCD) and 72.4% with RA as the nonunderlying cause of death (NUCD). Ninety percent of RA-related deaths occurred at age ≥ 50 years. The mean ages at death were 67.1 ± 13.3 and 67.9 ± 13 years for RA as the UCD and NUCD, respectively. The most frequent NUCD associated with RA were pneumonia, sepsis, renal failure, interstitial lung disease, and heart failure. In the last subperiod, there was an increase in infectious causes. When RA was an NUCD, we observed a decrease in the mean age at death for the last subperiod (p = 0.021). The most common UCD were circulatory and respiratory system diseases. Comparing the mean age at death between RA-related deaths and the general population when deaths occurred at ages beyond 50 years, the linear regression analysis showed a downward curve for RA-related death (p < 0.001 and r = −0.795), while for the general population, as expected, the curve had an upward pattern (p < 0.001 and r = 0.993).Conclusion.Unexpectedly, RA-related deaths occurred at earlier ages in the more recent subperiod. Cardiovascular disease remained the most important cause, and infectious diseases are an increasing cause of death associated with RA, raising the question of whether infections were related to the more vigorous immunosuppressive treatment recommended by recent guidelines.
Biomarkers in Remission According to Different Criteria in Patients with Rheumatoid Arthritis
Authors: Yilmaz-Oner Sibel , Ozen Gulsen , Can Meryem , Atagunduz Pamir , Direskeneli Haner , Inanc Nevsun 
Published: October 2015

Objective.Remission is the primary aim in the treatment of patients with rheumatoid arthritis (RA). In this study, we aimed to evaluate biomarker profiles of patients in remission by different criteria and compare these profiles with controls.Methods.Serum levels of calprotectin, interleukin 6 (IL-6), type II collagen helical peptide, C-terminal crosslinking telopeptide of type I collagen generated by matrix metalloproteinases (ICTP), matrix metalloproteinase 3 (MMP-3), resistin, and leptin were measured by ELISA in 80 patients. The patients were in Disease Activity Score at 28 joints with erythrocyte sedimentation rate (DAS28-ESR) remission, and had these characteristics: female/male 54/26, mean age 51.4 ± 12.1 years, mean disease duration 11.4 ± 8.1 years, rheumatoid factor positivity 68.7% (n = 55), anticyclic citrullinated peptide positivity 60.7% (n = 48). These patients were also evaluated for the American College of Rheumatology/European League Against Rheumatism (Boolean) and Simple Disease Activity Index (SDAI) remissions. Additionally, 80 age-, sex-, and comorbidity-matched individuals without rheumatic diseases were included in the study as controls.Results.At recruitment of 80 patients in DAS28 remission, 33 patients (41.2%) were found in Boolean remission and 39 patients (48.7%) were in SDAI remission. Serum MMP-3, ICTP, resistin, and IL-6 levels of the 80 patients in DAS28 remission were statistically significantly higher than the controls. Patients in Boolean and SDAI remissions had significantly higher serum ICTP, resistin, and IL-6 levels in comparison with the controls.Conclusion.The 3 commonly used remission criteria of RA are almost similar with regard to patients’ biomarker levels. Biomarker profiles of patients may provide complementary information to clinical evaluation of remission and may help to determine the patients under the risk of progression.
Le care , le caring , le cure et le soignant
Authors: Morvillers Jean-Manuel 
Published: October 2015

En raison de la polysémie du concept de care et de ses significations culturelles variées, le but de cet article est d’aborder ce concept en débutant par une clarification de ses origines étymologiques. Outre cette clarification, les objectifs de cet article consistent à faire ressortir les rapports du care avec ceux du cure , les implications du « care » dans le management des équipes de soins. L’analyse étymologique est réalisée à partir d’écrits encyclopédiques, permettant de discuter le sens originel du concept. Les résultats de cette analyse montrent que le sens d’origine du care s’ancre sur les affects et le ressenti, qui amènent au caring . Par conséquent, une dimension personnelle lui est inhérente. Cette réflexion tente de montrer que le care ne s’oppose pas au cure , mais qu’il est impératif de sensibiliser les infirmier(e)s à la dimension personnelle du care pour devenir le caring avec l’appui du management. La conclusion dévoile qu’une dimension personnelle du caring , soutenue par des valeurs humanistes, participe de la dimension professionnelle du rôle infirmier. Ainsi, ces deux dimensions, qui doivent croître ensemble, sont incontournables pour l’exercice infirmier.
L’enseignement du care en IFSI
Authors: Petrus-Krupsky Marie 
Published: October 2015

Les Instituts de formation en soins infirmiers (IFSI) sont acteurs de la formation initiale infirmière. A ce titre, ils sont également acteurs de la transmission du care . Le care constitue une philosophie pratique fondamentale, infrastructure et non super structure, sur laquelle s’appuient toutes les dimensions du soin infirmier. Il peut se définir comme une posture psychologique, psychique incarnée dans une posture corporelle et verbale au service d’une communication singulière à un être singulier. La réforme des études infirmières de juillet 2009 mise en œuvre par les IFSI a-t-elle une incidence sur ce postulat ? La redistribution des rôles entre les différents acteurs de l’enseignement infirmier (formateurs en IFSI, professionnels des terrains de stage et enseignants universitaires) est interrogée. Quels sont les données à voir du prescrit du nouveau référentiel et du réel des modes et des contenus d’enseignement ? Qu’en est-il aujourd’hui de la transmission du care lors de la formation initiale infirmière ? Et quelles sont les prospectives qui se dessinent ?
¿Por qué los yacimientos arqueológicos están tan pobremente representados en Internet?
Authors: Gómez Merino José Luis 
Published: October 2015

<p>In spite of the great growth of all human activities on internet, Archaeological settlements show a poor reflection in the most important media of the XXI Century. There aren 't useful models for a good communication of heritage. In most cases the historical significance of Archaeological sites and the human and economic resources allocated to them have a minimum mirror on Internet. </p>
Visualización tridimensional hiperrealista e interactiva: Cámara Santa y Joyas de la Catedral de Oviedo
Authors: Ruiz Julio , Rovés Luis , García Voces Ángel 
Published: October 2015

<p>The New developments in 3D data registration and post processing have enabled us to obtain models whose final design means a qualitative step in order to reach a much more realistic viewing of them for both cases: sculptures and architectural monuments. Uniting 3D scanning technologies, photogrammetry, texture mapping, 3D imaging software tools and interactive content, we found novel and higher levels of quality in the images. Thanks to the new software display - with these images made in Unity - a new field emerges which find applications in improved interactivity , cellular phones, tablets, augmented reality and related technologies, as well as in the development of future platforms such as holodisplays, auto stereoscopic 3D television computer vision, etc. In this way it provides an excellent tool for heritage but a valuable working tool for professionals too. </p>
Modelos digitales aplicados a la intervención del patrimonio arquitectónico: La restauración del remate sureste de la puerta de San Cristóbal en la catedral de Sevilla
Authors: Pinto Puerto Francisco , Guerrero Vega José María 
Published: October 2015

<p>Interventions in historical heritage present an opportunity to gain a deeper knowledge of the element in question. The use of an appropriate methodology and the rational application of the technologies now available allow researchers from different disciplines to obtain valuable information that must be recorded and placed at the disposal of society in general. The recent consolidation works carried out on the finial of the spiral staircase of the San Cristóbal Door of Seville Cathedral is a case in point. In addition to creating an elevation of this architectural element, a virtual model was generated, incorporating all the data obtained during the course of the works. The theoretical bases were explored prior to creating the model, highlighting the importance of a profound preliminary analysis as well as the dissemination possibilities. </p>
Forum Renascens (Los Bañales de Uncastillo, Zaragoza): Arqueología de la Arquitectura de un foro romano al servicio de la difusión por medio de la Arqueología Virtual
Authors: Serrano Basterra Pablo , Andreu Pintado Javier 
Published: October 2015

<p>An archaeological site concerning the remains of an ancient Roman city, developed mainly from 1st BC to III AD, in the area named "Los Bañales", is located at the south of the current town of Uncastillo (Zaragoza, Spain) in Comarca de las Cinco Villas. From 2008 the archaeological site is been studied in a interdisciplinar research project leaded by Fundación Uncastillo under the autorizathion of Gobierno de Aragón. Last seasons of excavation have been focused in the forum, the ancient public square of the roman town, still in process of research. It was a quite small square but following all the requeriments of those type of buildings in Roman Achitecture. Using Blender software, a model of recreation of the forum is being done. The following paper presents a brief summary of the dossier of decissions concerning this recreation result, however, of the interdisciplinar cooperation between historians, archaeologists and architects. </p>
Simulation Strategies to Teach Patient Transfers: Self-Efficacy by Strategy
Authors: Baird Joanne M. , Raina Ketki D. , Rogers Joan C. , O’Donnell John , Terhorst Lauren , Holm Margo B. 
Published: October 2015

Abstract
OBJECTIVE. We evaluated the effects of transfer training—after training in the classroom and in the high-technology simulation laboratory (WISER Center)—on students’ perceptions of their self-efficacy for knowledge, skill, and safety in executing dependent transfers.
METHOD. After classroom training, occupational therapy students were randomized to three teaching groups on the basis of the amount of participation and observation opportunities provided at the WISER Center—observation dominant, participation dominant, and participation only.
RESULTS. The participation-dominant group reported an increase in knowledge self-efficacy over time compared with the observation-dominant and participation-only groups. Over time, self-efficacy ratings increased for all students, regardless of group.
CONCLUSION. Simulation scenarios implemented at the WISER Center provided a useful adjunct to classroom training in transfer skills. Both participatory and observational experiences contributed to the development of students’ perceptions of their ability to manage acutely ill and medically complex patients.
Aspectos medioambientales en los análisis de eficiencia
Authors: Dios-Palomares Rafaela , Lopez de Pablo David Alcaide , Diz Pérez José , Jurado Bello Manuel , Guijarro Angel Prieto , Martinez-Paz Jóse Miguel , Zúniga González Carlos Alberto 
Published: October 2015

El presente estudio se focalizó en una revisión de investigaciones aplicadas utilizando variables agroclimáticas con la incorporación de efectos medio ambientales en el análisis de la eficiencia. Se consideró el análisis econométrico, el enfoque de la eficiencia técnico-ambiental, el enfoque eco-eficiencia, el enfoque metafronteras, enfoque de la eficiencia ambiental, el balance de materiales. Las conclusiones del estudio evidencia la necesidad de utilizar el análisis de eficiencia u productividad considerando los factores medioambientales y las variaciones del cambio climático. La importancia de estos factores incide en los procesos productivos para medir la eficiencia y la productividad. Se recomienda la investigación en el desarrollo de nuevas metodologías en esta parcela del análisis de eficiencia, y también que se apliquen las ya existentes para no llegar a malas estimaciones al no considerar la realidad que nos rodea.
Adjustments to Minimum Wages in China: Cost-Neutral Offsets
Authors: Wang Jing , Gunderson Morley 
Published: October 2015

Based on qualitative interviews of workers, managers and labour inspectors in China, we examine how employers adjust, often in subtle fashions, to minimum wage increases. Our findings highlight the “law of unintended consequences” in that their effects are often “undone” or offset by subtle adjustments such as reductions in fringe benefits and in overtime work and overtime pay premiums that are otherwise valued by employees. Employees often feel that they are no better off in spite of minimum wage increases because of these offsetting adjustments.
This study also suggests possible reasons for the small or zero effect of minimum wage on employment in China. Lack of enforcement may be one of the reasons, but the employees we interviewed seem well aware of the legal minimum wage and employers do not want to get involved in disputes over this matter. For employers who would otherwise be affected by the minimum wage increase, the cost increase is mitigated by the offsetting adjustments. As a result, minimum wages do not seem to weaken the competitive position of employers in China.
Headache in Chiari malformation: A distinct clinical entity?
Authors: Kesler Roman , Mendizabal Jorge E 
Published: October 2015

Abstract
A relatively common group of developmental anomalies of the posterior fossa and its contents make up the Chiari malformations. The most common of these anomalies are the Chiari malformations type I and type II. Many patients with these defects are asymptomatic, but many of them suffer from headaches. Although the prevalence of common primary headache disorders in patients with Chiari malformations is similar to that of the general population, a particular type of occipital headaches occurs more frequently in patients with a Chiari malformation. In the two patients described in the illustrative case presentations, the major complaint was headache. Both had Chiari malformation type I diagnosed. Chiari malformation should be considered in the differential diagnosis of patients who complain of exertional headache. Exertional headaches or worsening of pain during Valsalva's maneuver should prompt clinical suspicion of an underlying intracranial lesion and warrants further evaluation by appropriate neuroimaging studies.
Childhood obesity: Addressing the issue
Authors: Rudloff Loretta M , Feldmann Emily 
Published: October 2015

Abstract
Childhood obesity is a major health issue in pediatric practice. The old idea that "a chubby baby is a healthy baby" is not necessarily the case. Social stigmas and recidivism surrounding obesity make addressing families and their children difficult; however, with early intervention, treatment can be successful. Prevention of obesity with health maintenance surveillance and family-focused behavior modification is the foundation for a healthy lifestyle and may prove the most effective way of avoiding long-term obesity-related morbidity.
Pancreatic cystic neoplasms
Authors: Anderson Donald J , Matson Scott 
Published: October 2015

Abstract
Cystic neoplasms of the pancreas are relatively rare. This makes the evaluation and treatment of these tumors widely varied. The authors describe a patient who came to our hospital with complaints of abdominal pain, but no other related symptoms. Diagnostic evaluation of the patient yielded normal results, except for inspection and palpation of the abdominal areas, which revealed a large epigastric mass; this finding was confirmed subsequently by ultrasonographic examination and computed tomographic scanning. This article presents the case and reviews the literature, specifically related to diagnosis and current treatments.
Electron acceleration by parallel and perpendicular electric fields during magnetic reconnection without guide field
Authors: Bessho N. , Chen L.‐J. , Germaschewski K. , Bhattacharjee A. 
Published: October 2015

AbstractElectron acceleration due to the electric field parallel to the background magnetic field during magnetic reconnection with no guide field is investigated by theory and two‐dimensional electromagnetic particle‐in‐cell simulations and compared with acceleration due to the electric field perpendicular to the magnetic field. The magnitude of the parallel electric potential shows dependence on the ratio of the plasma frequency to the electron cyclotron frequency as (ωpe/Ωe)−2 and on the background plasma density as
. In the Earth's magnetotail, the parameter ωpe/Ωe∼9 and the background (lobe) density can be of the order of 0.01 cm−3, and it is expected that the parallel electric potential is not large enough to accelerate electrons up to 100 keV. Therefore, we must consider the effect of the perpendicular electric field to account for electron energization in excess of 100 keV in the Earth's magnetotail. Trajectories for high‐energy electrons are traced in a simulation to demonstrate that acceleration due to the perpendicular electric field in the diffusion region is the dominant acceleration mechanism, rather than acceleration due to the parallel electric fields in the exhaust regions. For energetic electrons accelerated near the X line due to the perpendicular electric field, pitch angle scattering converts the perpendicular momentum to the parallel momentum. On the other hand, for passing electrons that are mainly accelerated by the parallel electric field, pitch angle scattering converting the parallel momentum to the perpendicular momentum occurs. In this way, particle acceleration and pitch angle scattering will generate heated electrons in the exhaust regions.
Arctic pathways of Pacific Water: Arctic Ocean Model Intercomparison experiments
Authors: Aksenov Yevgeny , Karcher Michael , Proshutinsky Andrey , Gerdes Rüdiger , de Cuevas Beverly , Golubeva Elena , Kauker Frank , Nguyen An T. , Platov Gennady A. , Wadley Martin , Watanabe Eiji , Coward Andrew C. , Nurser A. J. George 
Published: October 2015

AbstractPacific Water (PW) enters the Arctic Ocean through Bering Strait and brings in heat, fresh water, and nutrients from the northern Bering Sea. The circulation of PW in the central Arctic Ocean is only partially understood due to the lack of observations. In this paper, pathways of PW are investigated using simulations with six state‐of‐the art regional and global Ocean General Circulation Models (OGCMs). In the simulations, PW is tracked by a passive tracer, released in Bering Strait. Simulated PW spreads from the Bering Strait region in three major branches. One of them starts in the Barrow Canyon, bringing PW along the continental slope of Alaska into the Canadian Straits and then into Baffin Bay. The second begins in the vicinity of the Herald Canyon and transports PW along the continental slope of the East Siberian Sea into the Transpolar Drift, and then through Fram Strait and the Greenland Sea. The third branch begins near the Herald Shoal and the central Chukchi shelf and brings PW into the Beaufort Gyre. In the models, the wind, acting via Ekman pumping, drives the seasonal and interannual variability of PW in the Canadian Basin of the Arctic Ocean. The wind affects the simulated PW pathways by changing the vertical shear of the relative vorticity of the ocean flow in the Canada Basin.