bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Bioactive Diphenyl Ether Derivatives from a Gorgonian‐Derived Fungus Talaromyces sp.
Authors: Chen Min , Han Lei , Shao Chang‐Lun , She Zhi‐Gang , Wang Chang‐Yun 
Published: July 2015

AbstractThree new diphenyl ether derivatives, talaromycins A—C, are isolated together with six known analogues and evaluated for their cytotoxic and antifouling activities.
ChemInform Abstract: Photocurrent Generation with Two‐Dimensional van der Waals Semiconductors
Authors: Buscema Michele , Island Joshua O. , Groenendijk Dirk J. , Blanter Sofya I. , Steele Gary A. , van der Zant Herre S. J. , Castellanos‐Gomez Andres 
Published: July 2015

AbstractReview: 221 refs.
ChemInform Abstract: Highlights on the Synthesis and Biological Activity of 1,3‐Selenazoles
Authors: Facchinetti Victor , Nery Ana C. S. , Avellar Marcela M. , Gomes Claudia R. B. , de Souza Marcus V. N. , Vasconcelos Thatyana R. A. 
Published: July 2015

AbstractReview: 59 refs.
ChemInform Abstract: Graphene‐Based Materials for Flexible Supercapacitors
Authors: Shao Yuanlong , El‐Kady Maher F. , Wang Lisa J. , Zhang Qinghong , Li Yaogang , Wang Hongzhi , Mousavi Mir F. , Kaner Richard B. 
Published: July 2015

AbstractReview: 235 refs.
New Synthesis of Trifluoromethyl Aldimines Containing L‐α‐Amino Ester Moieties and Their Use in Mannich‐Type Reactions
Authors: Parise Luca , Pelagalli Alessia , Trulli Laura , Vergari Maria Cecilia , Fioravanti Stefania , Pellacani Lucio 
Published: July 2015

AbstractL‐α‐Amino esters were considered valuable chiral starting materials in the condensation reaction with trifluoroacetaldehyde (fluoral) ethyl hemiacetal to obtain new functionalized trifluoromethyl aldimines. Starting from these latter compounds, isovaleraldehyde was used in proline‐catalyzed Mannich‐type addition reactions to give trifluoromethyl syn‐ or anti‐γ‐amino alcohols bearing the L‐α‐amino ester function, simply by changing the reaction temperature. Chirality 27:571–575, 2015. © 2015 Wiley Periodicals, Inc.
Comparative analysis of cervical cytology screening methods and staining protocols for detection rate and accurate interpretation of ASC‐H: Data from a high‐volume laboratory in Turkey
Authors: Ozlem Aydin , Umit Ince 
Published: July 2015

BackgroundThis study evaluated the effectiveness of the ThinPrep® Imaging System (TIS) and ThinPrep® Pap Stain (TPPS). A comparative analysis was conducted to determine the detection rates of atypical squamous cells, cannot exclude high‐grade squamous intraepithelial lesion (ASC‐H), the ASC:squamous intraepithelial lesion (SIL) ratio, biopsy follow‐up for ASC‐H in terms of the screening method used (manual screening [MS] vs. TIS screening [TISS]) and the staining protocol (regular Pap stain [RPS] vs. TPPS).MethodsThis study was performed over two periods. The RPS period included manually screened slides, whereas the TPPS period included TIS + manually screened slides. All data from the study periods were compared using statistical analysis.ResultsThe detection rate of ASC‐H was significantly higher during the TPPS period than during the RPS period (0.49% vs. 0.23%); this finding is in contrast to the insignificant difference between the screening method periods. The positive predictive value (PPV) of ASC‐H cytodiagnosis for cervical intraepithelial neoplasia of grade 2 or more severe histologies was significantly different between manually screened and TIS slides (22.10% vs. 38.55%), in contrast to an insignificant difference between RPS and TPPS periods (37.14% vs. 29.77%).ConclusionImplementation of the TIS did not change the ASC‐H detection rates appreciably. However, the new technology improved PPV for ASC‐H cytodiagnosis and enabled the detection of true disease. Our laboratory statistics indicate that the TPPS is not a superior staining protocol and did not increase our diagnostic accuracy for ASC‐H compared with RPS. Diagn. Cytopathol. 2015;43:863–869. © 2015 Wiley Periodicals, Inc.
Is there a relationship between the performance in a chronometric mental‐rotations test and salivary testosterone and estradiol levels in children aged 9–14 years?
Authors: Quaiser‐Pohl Claudia , Jansen Petra , Lehmann Jennifer , Kudielka Brigitte M. 
Published: July 2015

ABSTRACTThe consistent gender differences favoring males in some spatial abilities like mental rotation have raised the question of whether testosterone or other gonadal hormones contribute to these differences—especially because such gender differences seem to appear mainly from the age of puberty on. Studies generally suggest that spatial ability is facilitated by moderately high testosterone levels (i.e., levels that are relatively high for females and relatively low for males). However, the role of sex steroids for mental‐rotation performance of (pre‐) pubertal children has not been the focus of research, yet. In our study, the relationships between different aspects of mental‐rotation performance (accuracy, reaction time, rotation speed) and salivary testosterone and estradiol levels were investigated. Subjects were 109 children (51 boys and 58 girls) aged between 9 and 14 years (M = 11.41, SD = 1.74). They performed a chronometric mental‐rotations test, in which the stimuli consisted of three‐dimensional drawings of Shepard and Metzler cube figures. In addition, saliva samples were gathered for the analysis of free testosterone and estradiol levels. Results showed a significant gender difference in reaction time and rotational speed in favor of boys, and a significant age, but no gender difference in testosterone and estradiol levels. We found no significant relationships between hormonal levels and any measure of mental‐rotation performance. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 58:120–128, 2016.
Patterns of growth and tract formation during the early development of secondary lineages in the Drosophila larval brain
Authors: Lovick Jennifer K. , Kong Angel , Omoto Jaison J. , Ngo Kathy T. , Younossi‐Hartenstein Amelia , Hartenstein Volker 
Published: July 2015

ABSTRACTThe Drosophila brain consists of a relatively small number of invariant, genetically determined lineages which provide a model to study the relationship between gene function and neuronal architecture. In following this long‐term goal, we reconstruct the morphology (projection pattern and connectivity) and gene expression patterns of brain lineages throughout development. In this article, we focus on the secondary phase of lineage morphogenesis, from the reactivation of neuroblast proliferation in the first larval instar to the time when proliferation ends and secondary axon tracts have fully extended in the late third larval instar. We have reconstructed the location and projection of secondary lineages at close (4 h) intervals and produced a detailed map in the form of confocal z‐projections and digital three‐dimensional models of all lineages at successive larval stages. Based on these reconstructions, we could compare the spatio‐temporal pattern of axon formation and morphogenetic movements of different lineages in normal brain development. In addition to wild type, we reconstructed lineage morphology in two mutant conditions. (1) Expressing the construct UAS‐p35 which rescues programmed cell death we could systematically determine which lineages normally lose hemilineages to apoptosis. (2) so‐Gal4‐driven expression of dominant‐negative EGFR ablated the optic lobe, which allowed us to conclude that the global centrifugal movement normally affecting the cell bodies of lateral lineages in the late larva is causally related to the expansion of the optic lobe, and that the central pattern of axonal projections of these lineages is independent of the presence or absence of the optic lobe. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 434–451, 2016
Efficacy and safety of supramaximal titrated inhibition of renin‐angiotensin‐aldosterone system in idiopathic dilated cardiomyopathy
Authors: He Zheng , Sun Yun , Gao Hui , Zhang Jun , Lu Yuhong , Feng Jihua , Su Hongli , Zeng Chao , Lv Anlin , Cheng Kang , Li Yan , Li Huan , Luan Ronghua , Wang Ling , Yu Qiujun 
Published: July 2015

AbstractAimsThe optimal dosing strategies for blocking the renin‐angiotensin‐aldosterone system in idiopathic dilated cardiomyopathy (IDCM) are poorly known. We sought to determine the long‐term efficacy and safety of supramaximal titration of benazepril and valsartan in patients with IDCM.Methods and results480 patients with IDCM in New York Heart Association functional class II–IV and with left ventricular ejection fraction ≤35% were randomly assigned to extended‐release metoprolol (mean 152 mg/day, range 23.75–190), low‐dose benazepril (20 mg/day), low‐dose valsartan (160 mg/day), high‐dose benazepril (mean 69 mg/day, range 40–80), and high‐dose valsartan (mean 526 mg/day, range 320–640). After a median follow‐up of 4.2 years, high‐dose benazepril and valsartan, compared with their respective low dosages, resulted in 41% and 52% risk reduction in the primary endpoint of all‐cause death or admission for heart failure (P = 0.042 and 0.002), promoted functional improvement, and reversed remodelling as assessed by New York Heart Association classes, quality‐of‐life scores, and echocardiographic recording of left ventricular ejection fraction, left ventricular end‐diastolic volume, mitral regurgitation, and wall motion score index. Compared with metoprolol, high‐dose valsartan reduced risk for the primary endpoint by 46% (P = 0.006), whereas high‐dose benazepril and both low‐dose groups showed no significant difference. Major adverse events involved hypotension and renal impairment but were largely tolerated.ConclusionsSupramaximal doses of benazepril and valsartan were well tolerated and produced extra benefit than their low dosages in clinical outcome and cardiac reverse remodelling in patients with IDCM and modest‐severe heart failure. ClinicalTrials.gov identifier: NCT01917149.
Reduced risk of life‐threatening ventricular tachyarrhythmias with cardiac resynchronization therapy: relationship to left ventricular ejection fraction
Authors: Kutyifa Valentina , Moss Arthur J. , Solomon Scott D. , McNitt Scott , Aktas Mehmet K. , Barsheshet Alon , Merkely Bela , Zareba Wojciech , Goldenberg Ilan 
Published: July 2015

AimsWe hypothesized that the relationship between LVEF and the risk of life‐threatening ventricular tachyarrhythmias (VTAs) may modify the effect of a CRT device with a defibrillator (CRT‐D) on VTA risk.Methods and resultsThe risk of fast (≥200 b.p.m.) ventricular tachycardia/ventricular fibrillation (VT/VF) and the benefit of CRT‐D in reducing VT/VF were assessed by baseline LVEF (categorized as ≤30% or 30% and assessed as a continuous measurement) in 1783 patients with mild heart failure (HF) implanted with an implantable cardioverter defibrillator (ICD) or CRT‐D, enrolled in MADIT‐CRT. Higher LVEF (>30%) at baseline was associated with a significantly lower risk of fast VT/VF [hazard ratio (HR) 0.54, P = 0.006], VT/VF (HR 0.62, P = 0.005), and VT/VF/death (HR 0.64, P = 0.003). Treatment with CRT‐D was shown to reduce the risk of fast VT/VF in patients with LVEF ≤ 30% (n = 1100) [HR 0.64, 95% confidence intrerval (CI) 0.48–0.85, P = 0.002], but not among those with LVEF > 30% (n = 683) (HR 1.19, 95% CI 0.73–1.91, P = 0.502, interaction P‐value = 0.03). When LVEF was assessed as a continuous measure, each 5% increment was shown to be associated with a significant 30% (P < 0.001) reduction in the risk for fast VT/VF, and with a corresponding linear reduction in the benefit of CRT‐D in reducing fast VTA risk (P ‐value for treatment by LVEF interaction = 0.003).ConclusionsOur data suggest that in mild HF patients with cardiomyopathy there is an inverse correlation between LVEF and the risk of life‐threatening VTAs, possibly contributing to the attenuation in the antiarrhythmic properties of CRT with increasing left ventricular function.Trial registrationNCT00180271
Direct Electron Transfer and Bioelectrocatalysis by a Hexameric, Heme Protein at Nanostructured Electrodes
Authors: Tanne Johannes , Jeoung Jae‐Hun , Peng Lei , Yarman Aysu , Dietzel Birgit , Schulz Burkhard , Schad Daniel , Dobbek Holger , Wollenberger Ulla , Bier Frank F. , Scheller Frieder W. 
Published: July 2015

AbstractA nanohybrid consisting of poly(3‐aminobenzenesulfonic acid‐co‐aniline) and multiwalled carbon nanotubes [MWCNT‐P(ABS‐A)]) on a gold electrode was used to immobilize the hexameric tyrosine‐coordinated heme protein (HTHP). The enzyme showed direct electron transfer between the heme group of the protein and the nanostructured surface. Desorption of the noncovalently bound heme from the protein could be excluded by control measurements with adsorbed hemin on aminohexanthiol‐modified electrodes. The nanostructuring and the optimised charge characteristics resulted in a higher protein coverage as compared with MUA/MU modified electrodes. The adsorbed enzyme shows catalytic activity for the cathodic H2O2 reduction and oxidation of NADH.
Techno‐economic analysis of standalone hybrid energy systems to run auxiliaries of a cement plant located in Jamul, Chhattisgarh, India
Authors: Makhija Satya Prakash , Dubey S.P. 
Published: July 2015

This article proposes an optimal hybrid renewable energy system for auxiliaries of a cement plant located in Jamul, Chhattisgarh, India. Presently, the auxiliaries along with other loads are supplied electricity by coal based captive thermal power plant. The auxiliaries need to run without break. But, due to frequent failure of captive thermal power plant and also higher pollutant emissions, an optimal alternative system which comprises renewable source and existing diesel generator unit, was required to be proposed. For this, a comparative study is carried out by using HOMER software, among photo voltaic (PV)‐wind‐diesel‐battery (PWDB), PV‐diesel‐battery (PDB), and diesel‐only system. These systems are compared with one another considering total net present cost (NPC), pollutant emissions and cost of energy (COE). The required system constraints are taken to be zero maximum annual capacity shortage with a limit on the consumption of diesel and minimum renewable fraction equal to 800,000 L yr−1 and 30%, respectively. The study results show that PV‐wind‐diesel‐battery system has lowest NPC and COE and reduction in CO2 emissions are 11569.695 tons yr−1 compared to existing system emissions. Moreover, in this lowest NPC PV‐wind‐diesel‐battery system, the effect of using natural gas (NG), fuel oil (FO), and biodiesel (BD) in place of petroleum diesel is also studied in terms of variations of cost parameters and reductions in pollutant emissions. It is found that replacement of petroleum diesel with biodiesel results in further highest decrease in NPC, COE and pollutant emissions compared to other fuels. © 2015 American Institute of Chemical Engineers Environ Prog, 35: 221–229, 2016
Seismic fragility of plasterboard partitions via in‐plane quasi‐static tests
Authors: Petrone Crescenzo , Magliulo Gennaro , Lopez Pauline , Manfredi Gaetano 
Published: July 2015

SummaryThe seismic damage of internal partitions may cause significant earthquake loss; this phenomenon is caused by (a) their tendency to exhibit damage for low demand levels and (b) the consequent loss of inventory and breakdown that their collapse can cause.Quasi‐static tests are performed on six 5‐m‐high plasterboard internal partitions, which represent typical partitions in industrial and commercial buildings in the European area. A steel test setup is designed to transfer the load, which is provided by the actuator, to the partition. The testing protocol provided by Federal Emergency Management Agency (FEMA) 461 is adopted for the quasi‐static tests.The typical failure mode of the specimens is the buckling of a steel stud, which involves the boards that are attached to the buckled stud. The buckling failure usually concentrates across the plasterboard horizontal joints. A frictional behavior is exhibited for low demand levels, whereas a pinched behavior is shown for moderate‐to‐high demand levels.The interstory drift ratios required to reach a given damage limit state are evaluated using a predefined damage scheme. Based on the experimental data, the fragility curves for three different damage states (DS1, DS2, and DS3) are estimated. The fragility curve yields median interstory drift ratio values of 0.28%, 0.81%, and 2.05% and logarithmic standard deviations of 0.39, 0.42, and 0.46 for DS1, DS2, and DS3, respectively. Copyright © 2015 John Wiley & Sons, Ltd.
Transient responses of girder bridges with vertical poundings under near‐fault vertical earthquake
Authors: Yang Haibo , Yin Xiaochun 
Published: July 2015

SummaryPrevious studies on pounding responses of bridge structures mainly focus on the horizontal pounding between adjacent structures. However, the vertical pounding responses of bridge are rarely studied. The aim of this paper is develop a theoretical approach to investigate the transient behavior of continuous bridge under near‐fault vertical ground motions. The transient behavior of bridge manifests as the earthquake‐induced response wave and pounding‐induced response wave travel throughout bridge. Based on a new continuous model of beam–spring–rod, the theoretical solution of bridge responses involving multiple vertical poundings is derived by the expansion of transient wave functions in a series of eigenfunctions. A new theoretical solving approach of the multiple vertical pounding forces is presented based on the transient internal force on the contact surface of the girder and bearing. The numerical results show that the present method can reasonably capture the propagations of the earthquake‐induced response wave and pounding‐induced response wave. The calculations of pounding force by the present method are convergence of the time‐step size and truncation number of wave modes. As the effect of transient wave is taken into account, the numerical results show several transient phenomena involving the vertical pounding, the high pounding force, the multiple‐pounding phenomenon, the vertical separation of girder from the bearing, the dependence of poundings on earthquake period and the narrow period window of poundings. Copyright © 2015 John Wiley & Sons, Ltd.
Comparative toxicity of 20 herbicides to 5 periphytic algae and the relationship with mode of action
Authors: Nagai Takashi , Taya Kiyoshi , Yoda Ikuko 
Published: July 2015

Abstract

The authors used 5 species of periphytic algae to conduct toxicity assays of 20 herbicides. The 5 tested species represent riverine primary producers most likely to be affected by herbicides. A fluorescence microplate toxicity assay was used as an efficient and economical high-throughput assay. Toxicity characteristics were analyzed, focusing on their relationship to herbicide mode of action. The relative differences between 50% and 10% effect concentrations depended on herbicide mode of action, rather than tested species. Moreover, a clear relationship between sensitive species and herbicide mode of action was also observed. Green alga was most sensitive to herbicides of 2 mode of action groups: inhibitors of protoporphyrinogen oxidase and very long–chain fatty acid synthesis. Diatoms were most sensitive to herbicides of 1 mode of action group: 4-hydroxyphenyl-pyruvate-dioxygenase inhibitors. Cyanobacterium was most sensitive to herbicides of 1 mode of action group: inhibitors of acetolactate synthase. The species sensitivity distribution based on obtained data was also analyzed. The slopes of the species sensitivity distribution significantly differed among modes of action, suggesting that difference in species sensitivity is specific to the mode of action. In particular, differences in species sensitivity were markedly large for inhibitors of acetolactate synthase, protoporphyrinogen oxidase, and very long–chain fatty acid synthesis. The results clearly showed that a single algal species cannot represent the sensitivity of an algal assemblage. Therefore, multispecies algal toxicity data are essential for substances with specific modes of action. Environ Toxicol Chem 2016;35:368–375. © 2015 SETAC
A review on polarization‐based spectrum sensing
Authors: Guo C. L. , Li H. Y. 
Published: July 2015

AbstractIn cognitive radios, the biggest challenge is spectrum sensing. It usually makes use of the amplitude, frequency or space dimension of the received signal to differentiate signal from background noise. Polarization, also as an inherent characteristic of signals, provides an additional degree of freedom in signal space. Polarization‐based spectrum sensing has been identified as an effective method for improving detection performance. In this paper, various polarization‐based spectrum sensing methods including the optimal polarization likelihood ratio test using Neyman–Pearson theorem, virtual polarization detection utilizing maximum signal to noise ratio method and blind polarization detectors based on generalized likelihood ratio test method are reviewed. Then, a comprehensive comparison of various polarization‐based sensing methods in terms of detection performance and computational complexity is detailed. Finally, challenges and possible future studies on polarization‐based spectrum sensing are described. Copyright © 2015 John Wiley & Sons, Ltd.
Use of the Montreal Cognitive Assessment and Alzheimer's Disease‐8 as cognitive screening measures in Parkinson's disease
Authors: Brown Daniel S. , Bernstein Ira H. , McClintock Shawn M. , Munro Cullum C. , Dewey Richard B. , Husain Mustafa , Lacritz Laura H. 
Published: July 2015

ObjectiveTo examine the sensitivity and specificity of the Montreal Cognitive Assessment (MoCA), a brief cognitive screening measure previously validated for use in Parkinson's disease (PD), and Alzheimer's Disease‐8 (AD8), an eight‐item informant report used to screen for dementia, but not yet validated for use in PD, to identify cognitive impairment in a sample of 111 patients with PD.MethodsCognitive impairment was determined based on a battery of neuropsychological measures, excluding the MoCA and AD8. Classification rates of both the MoCA and AD8 in identifying cognitive impairment were examined using logistic regression and receiver operator characteristic (ROC) analysis. Optimal cutoff scores were determined to maximize sensitivity and specificity.ResultsThe MoCA correctly classified 78.4% of participants (p < 0.001), and ROC analysis yielded an area under the curve (AUC) of 0.82. A MoCA cutoff score of <25 yielded optimal sensitivity (0.77) and specificity (0.79) for identifying PD patients with cognitive impairment. Similar analyses for the AD8 were statistically nonsignificant, although the classification rate was 70.5%, with an AUC of 0.50.ConclusionsThese results provide additional support for the MoCA, but not the AD8, in identifying cognitive impairment in patients with PD. Copyright @ 2015 John Wiley & Sons, Ltd.