bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of an Integrative Coping and Resiliency Program for Nurses
Authors: Deible Stephanie , Fioravanti Marie , Tarantino Bonnie , Cohen Susan 
Published: January 2015

Purpose: To improve resiliency and reduce burnout in nurses through implementation of the Healing Pathways program (University of Maryland School of Medicine, Baltimore). Aims of this study include assessment of feasibility and acceptability and to explore changes in stress, coping, burnout, and mindfulness. Design: A single-group, pre-, posttest design of an 8-week program in which participants attended weekly sessions that included Reiki, yoga, and meditation. Sample included 8 nurses with 1 advanced practice nurse, all female, ages ranging from 22 to 49 years, experience levels ranging from <1 year to 26 years. Methods: Participants completed the Perceived Stress Scale, Coping Self-Efficacy Scale, Maslach Burnout Inventory, and Mindful Attention Awareness Scale before intervention, at last session, and 1 month after last session. Data were analyzed using one-way analysis of variance and qualitative narrative inquiry. Findings: Improvements were noted in perceived stress, coping, burnout exhaustion subscale, and mindfulness. Conclusion: Healing Pathways was effective at reducing stress and improving coping and mindfulness in nurses. Implications: Nurses who invest time in self-care techniques including Reiki, yoga, and meditation improve their overall wellbeing and may provide higher-quality patient care. Implementation of an 8-week program in integrative self-care is feasible and important for the health of nurses.
Complementary and Integrative Healthcare in a Long-term Care Facility: A Pilot Project
Authors: Evans Roni , Vihstadt Corrie , Westrom Kristine , Baldwin Lori 
Published: January 2015

Introduction: The world's population is aging quickly, leading to increased challenges of how to care for individuals who can no longer independently care for themselves. With global social and economic pressures leading to declines in family support, increased reliance is being placed on community- and government-based facilities to provide long-term care (LTC) for many of society's older citizens. Complementary and integrative healthcare (CIH) is commonly used by older adults and may offer an opportunity to enhance LTC residents’ wellbeing. Little work has been done, however, rigorously examining the safety and effectiveness of CIH for LTC residents. Objective: The goal of this work is to describe a pilot project to develop and evaluate one model of CIH in an LTC facility in the Midwestern United States. Methods: A prospective, mixed-methods pilot project was conducted in two main phases: (1) preparation and (2) implementation and evaluation. The preparation phase entailed assessment, CIH model design and development, and training. A CIH model including acupuncture, chiropractic, and massage therapy, guided by principles of collaborative integration, evidence informed practice, and sustainability, was applied in the implementation and evaluation phase. CIH services were provided for 16 months in the LTC facility. Quantitative data collection included pain, quality of life, and adverse events. Qualitative interviews of LTC residents, their family members, and LTC staff members queried perceptions of CIH services. Results: A total of 46 LTC residents received CIH care, most commonly for musculoskeletal pain (61%). Participants were predominantly female (85%) and over the age of 80 years (67%). The median number of CIH treatments was 13, with a range of 1 to 92. Residents who were able to provide self-report data demonstrated, on average, a 15% decline in pain and a 4% improvement in quality of life. No serious adverse events related to treatment were documented; the most common mild and expected side effect was increased pain (63 reports over 859 treatments). Qualitative interviews revealed most residents, family members and LTC staff members felt CIH services were worthwhile due to perceived benefits including pain relief and enhanced psychological and social wellbeing. Conclusion: This project demonstrated that with extensive attention to preparation, one patient-centered model of CIH in LTC was feasible on several levels. Quantitative and qualitative data suggest that CIH can be safely implemented and might provide relief and enhanced wellbeing for residents. However, some aspects of model delivery and data collection were challenging, resulting in limitations, and should be addressed in future efforts.
Teachers’ beliefs about diversity: an analysis from a personal and professional perspective
Authors: Chiner Esther , Cardona-Moltó María C. , Gómez Puerta José Marcos 
Published: January 2015

Abstract
The purpose of this study was to examine the beliefs that teachers have about diversity and their level of sensitivity towards some topics related to it. Moreover, beliefs were compared according to teachers’ personal and professional views and teaching experience. The Personal and Professional Beliefs about Diversity Scales (Pohan and Aguilar, 1999) were administered to a sample of 233 teachers. Results showed highly positive beliefs towards diversity in all its dimensions (cultural, linguistic and social diversity, ability, gender, sexual orientation and religion), especially regarding its personal implications compared to the professional ones. Likewise, it was observed a significant relationship between years of teaching experience and professional beliefs about diversity, so teachers with no school experience showed a higher tolerance than those with teaching experience, mainly in aspects related to cultural, linguistic and social differences, ability and gender. The implications that these results have for educational practice and the need for the development of multicultural education courses that favour an effective teaching are discussed.
Media Literacy through photography and participation. A conceptual approach
Authors: Rabadán Ángel V. 
Published: January 2015

Abstract
We are living in social massification processes that oppress our identity and specificity as a human group; however, there are tools increasingly present among researchers, educators and other professionals who help to develop interpretations and create knowledge by developing a participatory communication perspective.
This article discusses how communication and learning through dialogue and creative practice can be fostered with social interaction and dialogic processes generated through participatory photography workshops, in order to contribute to media literacy.
Similar to other creative experiences of this kind, this is not only a space to share products, jobs, tips and techniques, but also one for social interaction and communication. Educators in the field of media literacy can find, unprecedented challenges and opportunities in these initiatives to take advantage of the body of knowledge of adolescents and promote learning.
Educative Supervision in International Cooperation Contexts
Authors: Ortiz Ana , Valdivia-Moral Pedro , Cachón Javier , Prieto Joel 
Published: January 2015

Abstract
This present paper has got a clear goal: to contextualize education for development in the present moment, planning its evolution and the keys that characterize education collected from the most representative and up-to-date pieces of work. The experience that we present is integrated in a project developed in Paraguay that is expected to describe the professional characteristics of the school supervisors of the Republic of Paraguay and according to them, determine which are their training needs in order to establish the rules for the elaboration of a training programme that includes the guidelines that managers should know in order to exercise their role. The implementation of the abovementioned programme and the global evaluation of the project, complete the study with the second and third stages of the work. An empirical descriptive study of a transverse nature has been used. One of the conclusions worth mentioning is that two fifths of the supervisors have not received update course over the last three years and those who have taken it belong to very diverse areas.
A THREE-DIMENSIONAL OIL AND CHEMICAL SPILL MODEL FOR ENVIRONMENTAL IMPACT ASSESSMENT
Authors: Reed Mark , Rye Henrik 
Published: January 2015

ABSTRACT
A comprehensive model of the dynamic, three-dimensional physical fates of contaminants in the marine environment has been developed. For oil spills, dissolution of aromatics from surface slicks and entrained oil droplets are the source of potential effects for biota in the water column. Oil on the surface and along shorelines provides the basis for evaluation of impacts on birds, marine mammals, and recreational activities. A graphical user interface couples the model to a variety of environmental databases and tools to facilitate specific applications and viewing of simulation results.
A numerical investigation of boundary layer quasi‐equilibrium
Authors: Thayer‐Calder K. , Randall David 
Published: January 2015

AbstractDespite the large energy input from surface evaporation, the moist static energy (MSE) of the tropical boundary layer remains relatively constant on large spatial and temporal scales due to lifting of vapor by cloudy updrafts and the addition of dry air from the layers above. Arakawa and Schubert (1974) suggested that drying is due mainly to clear‐air turbulent entrainment between cloudy updrafts, while Raymond (1995) described drying due mainly to convective downdrafts. We used cloud‐resolving numerical simulations to investigate the transport of MSE into the boundary layer and found turbulent entrainment between clouds to be the dominant process.
First evidence for chorus at a large geocentric distance as a source of plasmaspheric hiss: Coordinated THEMIS and Van Allen Probes observation
Authors: Li W. , Chen L. , Bortnik J. , Thorne R. M. , Angelopoulos V. , Kletzing C. A. , Kurth W. S. , Hospodarsky G. B. 
Published: January 2015

AbstractRecent ray tracing suggests that plasmaspheric hiss can originate from chorus observed outside of the plasmapause. Although a few individual events have been reported to support this mechanism, the number of reported conjugate events is still very limited. Using coordinated observations between Time History of Events and Macroscale Interactions during Substorms (THEMIS) and Van Allen Probes, we report on an interesting event, where chorus was observed at a large L shell (~9.8), different from previously reported events at L < 6, but still exhibited a remarkable correlation with hiss observed in the outer plasmasphere (L ~ 5.5). Ray tracing indicates that a subset of chorus can propagate into the observed location of hiss on a timescale of ~5–6 s, in excellent agreement with the observed time lag between chorus and hiss. This provides quantitative support that chorus from large L shells, where it was previously considered unable to propagate into the plasmasphere, can in fact be the source of hiss.
Salinity‐buffered methane hydrate formation and dissociation in gas‐rich systems
Authors: You Kehua , Kneafsey Timothy J. , Flemings Peter B. , Polito Peter , Bryant Steven L. 
Published: January 2015

AbstractMethane hydrate formation and dissociation are buffered by salinity in a closed system. During hydrate formation, salt excluded from hydrate increases salinity, drives the system to three‐phase (gas, water, and hydrate phases) equilibrium, and limits further hydrate formation and dissociation. We developed a zero‐dimensional local thermodynamic equilibrium‐based model to explain this concept. We demonstrated this concept by forming and melting methane hydrate from a partially brine‐saturated sand sample in a controlled laboratory experiment by holding pressure constant (6.94 MPa) and changing temperature stepwise. The modeled methane gas consumptions and hydrate saturations agreed well with the experimental measurements after hydrate nucleation. Hydrate dissociation occurred synchronously with temperature increase. The exception to this behavior is that substantial subcooling (6.4°C in this study) was observed for hydrate nucleation. X‐ray computed tomography scanning images showed that core‐scale hydrate distribution was heterogeneous. This implied core‐scale water and salt transport induced by hydrate formation. Bulk resistivity increased sharply with initial hydrate formation and then decreased as the hydrate ripened. This study reproduced the salinity‐buffered hydrate behavior interpreted for natural gas‐rich hydrate systems by allowing methane gas to freely enter/leave the sample in response to volume changes associated with hydrate formation and dissociation. It provides insights into observations made at the core scale and log scale of salinity elevation to three‐phase equilibrium in natural hydrate systems.
Synthesis of Fluorescent Naphthoquinolizines via Intramolecular Houben–Hoesch Reaction
Authors: Stasyuk Anton J. , Smoleń Sabina , Glodkowska‐Mrowka Eliza , Brutkowski Wojciech , Cyrański Michał K. , Tkachenko Nikolai , Gryko Daniel T. 
Published: January 2015

AbstractThe repertoire of synthetic methods leading to aza‐analogues of polycyclic aromatic heterocycles has been enlarged by the discovery of the rearrangement of 10‐substituted benzo[h]quinolines into compounds bearing an azonia‐pyrene moiety. Acid‐mediated intramolecular cyclization of derivatives bearing ‐CH2CN and ‐CH2CO2Et groups led to compounds bearing a 5‐substituted benzo[de]pyrido[3,2,1‐ij]quinolinium core. Advanced photophysical studies including time‐correlated single photon counting (TCSPC) and transient absorption spectroscopy of 5‐aminobenzo[de]pyrido[3,2,1‐ij]quinolin‐4‐ium salt and 5H‐benzo[de]pyrido[3,2,1‐ij]quinolin‐5‐one showed their promising optical properties such as high fluorescence quantum yields (37–59 %), which was almost independent of the solvent, and high tenability of the absorption band position upon changing the solvent. The benzo[de]pyrido[3,2,1‐ij]quinolinium salt selectively stains nucleic acids (in the nucleus and mitochondria) in eukaryotic cells.
PIAS3 expression in squamous cell lung cancer is low and predicts overall survival
Authors: Abbas Rime , McColl Karen S. , Kresak Adam , Yang Michael , Chen Yanwen , Fu Pingfu , Wildey Gary , Dowlati Afshin 
Published: January 2015

AbstractUnlike lung adenocarcinoma, little progress has been made in the treatment of squamous cell lung carcinoma (SCC). The Cancer Genome Atlas (TCGA) has recently reported that receptor tyrosine kinase signaling pathways are altered in 26% of SCC tumors, validating the importance of downstream Signal Transducers and Activators of Transcription 3 (STAT3) activity as a prime therapeutic target in this cancer. In the present report we examine the status of an endogenous inhibitor of STAT3, called Protein Inhibitor of Activated STAT3 (PIAS3), in SCC and its potential role in this disease. We examine PIAS3 expression in SCC tumors and cell lines by immunohistochemistry of a tissue microarray and western blotting. PIAS3 mRNA expression and survival data are analyzed in the TCGA data set. SCC cell lines are treated with curcumin to regulate PIAS3 expression and cell growth. PIAS3 protein expression is decreased in a majority of lung SCC tumors and cell lines. Analysis of PIAS3 mRNA transcript levels demonstrated that low PIAS3 levels predicted poor survival; Cox regression analysis revealed a hazard ratio of 0.57 (95% CI: 0.37–0.87), indicating a decrease in the risk of death by 43% for every unit elevation in PIAS3 gene expression. Curcumin treatment increased endogenous PIAS3 expression and decreased cell growth and viability in Calu‐1 cells, a model of SCC. Our results implicate PIAS3 loss in the pathology of lung SCC and raise the therapeutic possibility of upregulating PIAS3 expression as a single target that can suppress signaling from the multiple receptor tyrosine kinase receptors found to be amplified in SCC.
Neurite outgrowth resistance to rho kinase inhibitors in PC12 Adh cell
Authors: Yin Hua , Hou Xiaolin , Tao Tingrui , Lv Xiaoman , Zhang Luyong , Duan Weigang 
Published: January 2015

AbstractRho kinase (ROCK) inhibitor is a promising agent for neural injury disorders, which mechanism is associated with neurite outgrowth. However, neurite outgrowth resistance occurred when PC12 Adh cell was treated with ROCK inhibitors for a longer time. PC12 Adh cells were treated with ROCK inhibitor Y27632 or NGF for different durations. Neurite outgrowth resistance occurred when PC12 Adh cell exposed to Y27632 (33 µM) for 3 or more days, but not happen when exposed to nerve growth factor (NGF, 100 ng/mL). The gene expression in the PC12 Adh cells treated with Y27632 (33 µM) or NGF (100 ng/mL) for 2 or 4 days was assayed by gene microarray, and the reliability of the results were confirmed by real‐time RT‐PCR. Cluster analysis proved that the gene expression profile of PC12 Adh cell treated with Y27632 for 4 days was different from that treated with Y27632 for 2 days and those treated with NGF for 2 and 4 days, respectively. Pathway analysis hinted that the neurite outgrowth resistance could be associated with up‐regulation of inflammatory pathways, especially rno04610 (complement and coagulation cascades), and down‐regulation of cell cycle pathways, especially rno04110.
The effect of the size of fluorescent dextran on its endocytic pathway
Authors: Li Lei , Wan Tao , Wan Min , Liu Bei , Cheng Ran , Zhang Rongying 
Published: January 2015

AbstractFluorescent dextrans are commonly used as macropinocytic probes to study the properties of endocytic cargoes; however, the effect of the size of dextrans on endocytic mechanisms has not been carefully analyzed. By using chemical and siRNA inhibition of individual endocytic pathways, we evaluated the internalization of two commonly used dextrans, Dex10 (dextran 10 kDa) and Dex70 (dextran 70 kDa), in mammalian HeLa cells and Caenorhabditis elegans coelomocytes. We revealed that Dex70 enters these two cell types predominantly via clathrin‐ and dynamin‐independent and amiloride‐sensitive macropinocytosis process; Dex10, on the other hand, enters the two cell types through clathrin‐/dynamin‐dependent micropinocytosis in addition to macropinocytosis. In addition, although different‐sized dextrans follow different endocytic processes, they share common post‐endocytic events. Herein, though straightforward, our studies support that the size of nanomaterials could play a paramount role in their inclusion into endocytic vesicles and suggest that care should be taken while selecting endocytic pathway markers. Based on our results, we propose that Dex70 is a better probe for macropinocytosis, whereas Dex10 and smaller molecules are better for probing general fluid‐phase endocytosis, which includes macropinocytic and micropinocytic processes.
Expression and function of fatty acid‐binding protein 4 in epithelial cell of uterine endometrium
Authors: Zhu Qiuyuan , Jin Yan , Wang Peng , Wang Hanzhi , Lu Bingjian , Wang Zhengping , Dong Minyue 
Published: January 2015

AbstractThe aims of this study were to delineate the expression of fatty‐acid binding protein (FABP) 4 in human uterine endometrium and its function in the regulation of proliferation, migration and invasion of epithelial cells. Immunohistochenistry, immunofluorence and Western blotting were used to determine the expression and cellular localization of FABP4 in endometrium and endometrial epithelial cell lines. Interference of small ribonuclear acid (siRNA) and specific FABP4 inhibitor were used to inhibit FABP4. The proliferation, migration and invasion of epithelial cells were evaluated with CCK‐8 assay, wound‐healing test and transwell analysis respectively. We found that FABP4 was expressed by epithelial cells of proliferative endometrium and epithelial and stromal cells of secrectory endometrium. Epithelial cell lines Ishikawa and RL‐952 expressed FABP4 and this expression was decreased by FABP4 siRNA. FABP4 siRNA and specific FABP4 inhibition significantly decreased the proliferation, migration and invasion of epithelial cell lines. We concluded that FABP4 is functionally expressed in endometrial epithelium and is necessary for maintaining the cell function of epithelial cells of endometrium.
Differential effect of Activin A and WNT3a on definitive endoderm differentiation on electrospun nanofibrous PCL scaffold
Authors: Hoveizi Elham , Massumi Mohammad , Ebrahimi‐barough Somayeh , Tavakol Shima , Ai Jafar 
Published: January 2015

AbstractThe first step in the formation of hepatocytes and beta cells is the generation of definitive endoderm (DE) which involves a central issue in developmental biology. Human induced pluripotent stem cells (hiPSCs) have the pluripotency to differentiate into all three germ layers in vitro and have been considered potent candidates for regenerative medicine as an unlimited source of cells for therapeutic applications. In this study, we investigated the differentiating potential of hiPSCs on poly (ε‐caprolactone) (PCL) nanofibrous scaffold into DE cells. Here, we demonstrate directed differentiation of hiPSCs by factors such as Activin A and Wnt3a. The differentiation was determined by immunofluoresence staining with Sox17, FoxA2 and Goosecoid (Gsc) and also by qRT‐PCR analysis. The results of this study showed that hiPSCs, as a new cell source, have the ability to differentiate into DE cells with a high capacity and also demonstrate that three dimension (3D) culture provides a suitable nanoenviroment for growth, proliferation and differentiation of hiPSCs. PCL nanofibrous scaffold with essential supplements, stimulating factors and EB‐derived cells is able to provide a novel method for enhancing functional differentiation of hiPSCs into DE cells.
Longer‐term outcome of perventricular device closure of muscular ventricular septal defects in children
Authors: Kang Sok Leng , Tometzki Andrew , Caputo Massimo , Morgan Gareth , Parry Andrew , Martin Robin 
Published: January 2015

ObjectiveTo describe the longer‐term clinical experience and follow‐up with perventricular device closure of ventricular septal defects (VSD) in children.MethodsBetween January 2005 and December 2013, muscular ventricular septal defect closure with the Amplatzer Muscular VSD Occluder was undertaken using a hybrid perventricular approach. Data including demographic, echocardiographic parameter, and clinical outcome were reviewed retrospectively.ResultsMedian age at the time of procedure was 8.9 months (range 1.9–31.0 months) and median weight was 6.6 kg (range 4.5–12.9 kg). All had a moderate to large muscular VSD, three had more than one VSD, four had previous coarctation repair, and five had previous pulmonary artery (PA) banding. A single Amplatzer muscular occluder (range 8–18 mm) was deployed in each patient without cardiopulmonary bypass under echocardiographic guidance. Two of ten patients subsequently required a short period of cardiopulmonary bypass for reconstruction of PA after de‐banding and closure of atrial septal defect in one. Occluder removal was necessary in one patient due to entrapment of the tricuspid valve and progressive tricuspid regurgitation. This patient underwent surgical repair with a good result and no device‐related valve damage. In the remaining nine patients, no severe complications such as device embolization, arrhythmia, or significant valve regurgitation were noted in the post‐operative period or follow‐up. At a median time of 6.5 years (range 0.9–8.4 years) post device implantation, complete closure was achieved in five patients and four had small residual leaks, which were not hemodynamically significant.ConclusionPerventricular muscular VSD closure is effective in small children with suitable muscular defects and may avoid the morbidity associated with cardiopulmonary bypass and conventional surgical repair. There have been no late complications with this approach. © 2015 Wiley Periodicals, Inc.