bluuebunny/crossref_metadata_2025_split huggingface dataset:
AH-7921: the list of new psychoactive opioids is expanded
Authors: Katselou Maria , Papoutsis Ioannis , Nikolaou Panagiota , Spiliopoulou Chara , Athanaselis Sotiris 
Published: February 2015

Abstract
AH-7921 is a structurally unique synthetic opioid analgesic that has recently entered the drug arena in Europe, the USA, and Japan. Although it was synthesized and patented in the mid-1970s, it was first identified in a seized sample purchased via the Internet in July 2012 and formally brought to the attention of the European Union early warning system in August 2012 by the United Kingdom. Several in vitro experiments and animal model studies established the morphine-like analgesic action of AH-7921 as a μ-opioid receptor agonist that has been found to be several times more potent than codeine and at least as potent as morphine. This novel psychoactive substance has already led to eight non-fatal intoxications and 16 deaths in Sweden, the United Kingdom, Norway, and the USA. Thus, AH-7921 is a current public health risk, and better international collaboration, effective legislation and continuous community alertness are needed to tackle this current growing problem. The aim of this review is to summarize the current knowledge about this drug concerning its chemistry, pharmacology, and toxicology, as well as its international legal status. The limited existing analytical methodologies for the determination of AH-7921 in biological samples are also presented. Published or reported AH-7921-related cases, fatalities, or intoxications, and self reports from drug users are reviewed.
Modified Percutaneous Needle Aponeurotomy for the Treatment of Dupuytren's Contracture: Early Results and Complications
Authors: Herrera Fernando A. , Mitchell Scott , Elzik Mark , Roostaeian Jason , Benhaim Prosper 
Published: February 2015

Background The purpose of our study was to identify postoperative results and complications using a percutaneous approach to treat Dupuytren's contracture in a consecutive series of patients. Methods A review of all patients with Dupuytren's contracture treated with percutaneous needle aponeurotomy (NA) from 2008 to 2010 was performed. Patient demographics, digits affected, and disease severity was recorded. Preoperative total passive extension deficit (TPED) was calculated for each affected digit. TPED in the immediate postoperative period and at the time of most recent follow-up was measured. Treatment-related complications and incidence of disease recurrence were identified. Statistical analysis was performed using paired t-test. (Statistical significance p-value <0.05). Results 525 digits in 193 hands were treated with NA. 140 patients were male, average age was 65 years. The average preoperative TPED was 41° and the average immediate postoperative TPED was 1° (98% correction) ( P=0.0001). The average TPED at 4.5 month follow up was 11 o (73% correction). Complications included infection in 3 patients and one case each of triggering, delayed flexor tendon rupture, complex regional pain syndrome and persistent numbness. Recurrence was observed in 62 digits. Conclusion Percutaneous needle aponeurotomy is an effective technique in the treatment of Dupuytren's contracture. Near complete correction of contracture was achieved and few complications were observed. Longer follow-up is needed to determine if these short-term results are maintained.
American Medical Society for Sports Medicine (AMSSM) Position Statement: Interventional Musculoskeletal Ultrasound in Sports Medicine
Authors: Finnoff Jonathan T. , Hall Mederic M. , Adams Erik , Berkoff David , Concoff Andrew L. , Dexter William , Smith Jay 
Published: February 2015

AbstractThe use of diagnostic and interventional ultrasound has significantly increased over the past decade. A majority of the increased utilization is by nonradiologists. In sports medicine, ultrasound is often used to guide interventions such as aspirations, diagnostic or therapeutic injections, tenotomies, releases, and hydrodissections. This American Medical Society for Sports Medicine (AMSSM) position statement critically reviews the literature and evaluates the accuracy, efficacy, and cost‐effectiveness of ultrasound‐guided injections in major, intermediate, and small joints, and soft tissues, all of which are commonly performed in sports medicine. New ultrasound‐guided procedures and future trends are also briefly discussed. Based upon the evidence, the official AMSSM position relevant to each subject is made.
Tenuous Affair: Environmental and Outdoor Education in Aotearoa New Zealand
Authors: Irwin David , Straker Jo 
Published: February 2015

AbstractThe relationship between outdoor education and environmental education in Aotearoa New Zealand has undergone many changes since formal education began in early colonial times. Discussion draws from qualitative doctoral research undertaken by the authors that investigated education for sustainability in outdoor education and how meaning is ascribed to outdoor experiences. The article describes how environmental education and outdoor education had common historical roots in nature studies that eventually were teased apart by the development of separate agendas for learning and assessment, coupled with the political context of the 1970s and 1980s. The article finds that contemporary forces relating to the economy, society and the environment are now driving a re-engagement of the two discourses in Aotearoa New Zealand at a variety of levels, from schools to national bodies, and that this re-engagement signals a positive outcome for addressing key environmental issues and engaging students in the outdoors.
Rates of elastic compression stockings prescription following the diagnosis of deep venous thrombosis among Canadian emergency physicians and trainees
Authors: Kayssi Ahmed , Petrosoniak Andrew , Levenstadt Jeremy , Eisenberg Naomi , Jenkins Sue , Roche-Nagle Graham 
Published: February 2015

AbstractIntroductionPostthrombotic syndrome (PTS) is a complication of deep vein thrombosis (DVT) characterized by chronic pain, swelling, and heaviness, and may result in ulceration. Elastic compression stockings (ECS) worn daily after DVT have been shown to reduce the incidence and severity of PTS. The aim of our study was to investigate practices and perceptions of physicians regarding adjunct therapies to anticoagulation in patients diagnosed with lower extremity DVT.MethodsA national online survey was conducted of Canadian emergency medicine staff physicians and residents (n=471) to investigate their attitudes toward the prescription of ECS post-diagnosis of DVT. A paper survey of patients in a thrombosis clinic (n=58) was also administered to better understand the patient experiences with ECS.ResultsThe majority of staff physician (62%) and resident (69%) respondents were unsure of whether ECS were effective in preventing PTS and managing venous symptoms. Only 6% of staff physicians and 7% of residents routinely prescribed ECS for above-knee DVTs. More than 78% of respondents were unsure about the optimal timing of initiation of ECS and duration of therapy. Although all patients noted symptomatic relief with ECS, only 50% were prescribed stockings by an emergency or family doctor, and 69% of those patients wore the stockings on a daily basis. Staff physicians most frequently identified poor fit as the reason for lack of patient compliance, whereas patients most frequently cited cost.ConclusionsOur findings suggest that there is variability in practice among Canadian emergency medicine physicians and trainees and a need for widespread education regarding the latest evidence of the benefit of ECS after DVT.
Accuracy of physician-estimated probability of brain injury in children with minor head trauma
Authors: Daymont Carrie , Klassen Terry P. , Osmond Martin H. 
Published: February 2015

AbstractObjectiveTo evaluate the accuracy of physician estimates of the probability of intracranial injury in children with minor head trauma.MethodsThis is a subanalysis of a large prospective multicentre cohort study performed from July 2001 to November 2005. During data collection for the derivation of a clinical prediction rule for children with minor head trauma, physicians indicated their estimate of the probability of brain injury visible on computed tomography (P-Injury) and the probability of injury requiring intervention (P-Intervention) by choosing one of the following options: 0%, 1%, 2%, 3%, 4%, 5%, 10%, 20%, 30%, 40%, 50%, 75%, 90%, and 100%. We compared observed frequencies to expected frequencies of injury using Pearson’s χ2-test in analyses stratified by the level of each type of predicted probability and by year of age.ResultsIn 3771 eligible subjects, the mean predicted risk was 4.6% (P-Injury) and 1.4% (P-Intervention). The observed frequency of injury was 4.1% (any injury) and 0.6% (intervention). For all levels of P-Injury from 1% to 40%, the observed frequency of injury was consistent with the expected frequency. The observed frequencies for the 50%, 75%, and 90% levels were lower than expected (p<0.05). For estimates of P-Intervention, the observed frequency was consistently higher than the expected frequency. Physicians underestimated risk for infants (mean P-Intervention 6.2%, actual risk 12.3%, p<0.001).ConclusionsPhysician estimates of probability of any brain injury in children were collectively accurate for children with low and moderate degrees of predicted risk. Risk was underestimated in infants.
Rate of involuntary admission in Dublin South West: a 5-year retrospective review
Authors: McManus S. , McDonnell B. , Whitty P. 
Published: February 2015

ObjectiveInternational figures for involuntary admissions vary widely. Differences in legislation, professionals’ ethics and public attitudes towards risk have been known to influence this rate. Comparing involuntary admission rates in different parts of the same country can help control for variability found between international studies. This study assessed the rates of involuntary admissions in the Dublin South West Mental Health Service compared with the rest of Ireland.MethodsWe examined the demographic and clinical profiles of all involuntary patients admitted to the acute psychiatric inpatient unit in Tallaght Hospital between 2007 and 2011. We compared the rate of admission in Tallaght with the rest of Ireland. Data gathered included all patients detained on Form 6 and Form 13 (change of status) looking at age, gender, diagnosis and number of patients who had a Mental Health Tribunal. Form 7 (renewal orders) was also examinedWe calculated the rate per 100 000 population per year of Form 6 admissions, Form 13 and Form 7 (certificate and renewal order by responsible consultant psychiatrist) using figures from the 2006 Census. All data were analysed using SPSS.ResultsThe rate of involuntary admission in Tallaght Hospital was significantly lower compared with the rest of Ireland (Form 6: t=−11.2; p<0.001, Form 13: t=−3.1; p=0.04, Form 7: t=−13.9; p=0.001). This difference was evident for all methods of involuntary detention and was also the case for Form 7 (renewal orders). Mental Health Tribunals were held for 59% of patients, a rate comparable with earlier findings described in publications, following the introduction of the new Mental Health Act.ConclusionsRates per 100 000 population were lower in Dublin South West compared with the rest of Ireland. The reasons for this are not clear. Further research comparing similar services in Ireland could explain these findings.
Lift and thrust generation by a butterfly-like flapping wing–body model: immersed boundary–lattice Boltzmann simulations
Authors: Suzuki Kosuke , Minami Keisuke , Inamuro Takaji 
Published: February 2015

AbstractThe flapping flight of tiny insects such as flies or larger insects such as butterflies is of fundamental interest not only in biology itself but also in its practical use for the development of micro air vehicles (MAVs). It is known that a butterfly flaps downward for generating the lift force and backward for generating the thrust force. In this study, we consider a simple butterfly-like flapping wing–body model in which the body is a thin rod and the rectangular rigid wings flap in a simple motion. We investigate lift and thrust generation of the model by using the immersed boundary–lattice Boltzmann method. First, we compute the lift and thrust forces when the body of the model is fixed for Reynolds numbers in the range of 50–1000. In addition, we estimate the supportable mass for each Reynolds number from the computed lift force. Second, we simulate free flights when the body can only move translationally. It is found that the expected supportable mass can be supported even in the free flight except when the mass of the body relative to the mass of the fluid is too small, and the wing–body model with the mass of actual insects can go upward against the gravity. Finally, we simulate free flights when the body can move translationally and rotationally. It is found that the body has a large pitch motion and consequently gets off-balance. Then, we discuss a way to control the pitching angle by flexing the body of the wing–body model.
The kinematics of the reduced velocity gradient tensor in a fully developed turbulent free shear flow
Authors: Rabey P. K. , Wynn A. , Buxton O. R. H. 
Published: February 2015

AbstractThis paper examines the kinematic behaviour of the reduced velocity gradient tensor (VGT),$\tilde{\unicode[STIX]{x1D608}}_{ij}$, which is defined as a$2\times 2$block, from a single interrogation plane, of the full VGT$\unicode[STIX]{x1D608}_{ij}=\partial u_{i}/\partial x_{j}$. Direct numerical simulation data from the fully developed turbulent region of a nominally two-dimensional mixing layer are used in order to examine the extent to which information on the full VGT can be derived from the reduced VGT. It is shown that the reduced VGT is able to reveal significantly more information about regions of the flow in which strain rate is dominant over rotation. It is thus possible to use the assumptions of homogeneity and isotropy to place bounds on the first two statistical moments (and their covariance) of the eigenvalues of the reduced strain-rate tensor (the symmetric part of the reduced VGT) which in turn relate to the turbulent strain rates. These bounds are shown to be dependent upon the kurtosis of$\partial u_{1}/\partial x_{1}$and another variable defined from the constituents of the reduced VGT. The kurtosis is observed to be minimised on the centreline of the mixing layer and thus tighter bounds are possible at the centre of the mixing layer than at the periphery. Nevertheless, these bounds are observed to hold for the entirety of the mixing layer, despite departures from local isotropy. The interrogation plane from which the reduced VGT is formed is observed not to affect the joint probability density functions (p.d.f.s) between the strain-rate eigenvalues and the reduced strain-rate eigenvalues despite the fact that this shear flow has a significant mean shear in the cross-stream direction. Further, it is found that the projection of the eigenframe of the strain-rate tensor onto the interrogation plane of the reduced VGT is also independent of the plane that is chosen, validating the approach of bounding the full VGT using the assumption of local isotropy.
Saturation of equatorial inertial instability
Authors: Kloosterziel R. C. , Orlandi P. , Carnevale G. F. 
Published: February 2015

AbstractInertial instability in parallel shear flows and circular vortices in a uniformly rotating system ( $f$-plane) redistributes absolute linear momentum or absolute angular momentum in such a way as to neutralize the instability. In previous studies we showed that, in the absence of other instabilities, at high Reynolds numbers the final equilibrium can be predicted with a simple construction based on conservation of total momentum. In this paper we continue this line of research with a study of barotropic shear flows on the equatorial ${\it\beta}$-plane. Through numerical simulations the evolution of the instability is studied in select illuminating cases: a westward flowing Gaussian jet with the flow axis exactly on the equator, a uniform shear flow and eastward and westward flowing jets that have their flow axis shifted away from the equator. In the numerical simulations it is assumed that there are no along-stream variations. This suppresses equatorial Rossby waves and barotropic shear instabilities and allows only inertial instability to develop. We investigate whether for these flows on the equatorial ${\it\beta}$-plane the final equilibrated flow can be predicted as was possible for flows on the $f$-plane. For the Gaussian jet centred on the equator the prediction of the equilibrated flow is obvious by mere inspection of the initial momentum distribution and by assuming that momentum is mixed and homogenized to render the equilibrated flow inertially stable. For the uniform shear flow, however, due to the peculiar nature of the initial momentum distribution and the fact that the Coriolis parameter $f$ varies with latitude, it appears that, unlike in our earlier studies of flows on the $f$-plane, additional constraints need to be considered to correctly predict the outcome of the highly nonlinear evolution of the instability. The mixing range of the linear shear flow and the value of the mixed momentum is determined numerically and this is used to predict the equilibrated flow that emerges from an eastward flowing jet that is shifted a small distance away from the equator. For shifts large enough to induce no shear at the equator the equilibrium flow can be well predicted using the simple recipe used in our earlier studies of parallel shear flows on the $f$-plane. For the westward flowing jet shifted a very small distance from the equator, no prediction appears feasible. For modestly small shifts a prediction is possible by combining the empirical prediction for the linear shear flow with a prediction similar to what we used in our previous studies for flows on the $f$-plane.
Weakly nonlinear analysis of Rayleigh–Bénard convection in shear-thinning fluids: nature of the bifurcation and pattern selection
Authors: Bouteraa M. , Nouar C. , Plaut E. , Metivier C. , Kalck A. 
Published: February 2015

AbstractA linear and weakly nonlinear analysis of convection in a layer of shear-thinning fluids between two horizontal plates heated from below is performed. The objective is to examine the effects of the nonlinear variation of the viscosity with the shear rate on the nature of the bifurcation, the planform selection problem between rolls, squares and hexagons, and the consequences on the heat transfer coefficient. Navier’s slip boundary conditions are used at the top and bottom walls. The shear-thinning behaviour of the fluid is described by the Carreau model. By considering an infinitesimal perturbation, the critical conditions, corresponding to the onset of convection, are determined. At this stage, non-Newtonian effects do not come into play. The critical Rayleigh number decreases and the critical wavenumber increases when the slip increases. For a finite-amplitude perturbation, nonlinear effects enter in the dynamic. Analysis of the saturation coefficients at cubic order in the amplitude equations shows that the nature of the bifurcation depends on the rheological properties, i.e. the fluid characteristic time and shear-thinning index. For weakly shear-thinning fluids, the bifurcation is supercritical and the heat transfer coefficient increases, as compared with the Newtonian case. When the shear-thinning character is large enough, the bifurcation is subcritical, pointing out the destabilizing effect of the nonlinearities arising from the rheological law. Departing from the onset, the weakly nonlinear analysis is carried out up to fifth order in the amplitude expansion. The flow structure, the modification of the viscosity field and the Nusselt number are characterized. The competition between rolls, squares and hexagons is investigated. Unlike Albaalbaki & Khayat (J. Fluid. Mech., vol. 668, 2011, pp. 500–550), it is shown that in the supercritical regime, only rolls are stable near onset.
Stretching of capsules in an elongation flow, a route to constitutive law
Authors: de Loubens C. , Deschamps J. , Boedec G. , Leonetti M. 
Published: February 2015

AbstractSoft bio-microcapsules are drops bounded by a thin elastic shell made of cross-linked proteins. Their shapes and their dynamics in flow depend on their membrane constitutive law characterized by shearing and area-dilatation resistance. The deformations of such capsules are investigated experimentally in planar elongation flows and compared with numerical simulations for three bidimensional models: Skalak, neo-Hookean and generalized Hooke. An original cross-flow microfluidic set-up allows the visualization of the deformed shape in the two perpendicular main fields of view. Whatever the elongation rate, the three semi-axis lengths of the ellipsoid fitting the experimental shape are measured up to 180 % of stretching of the largest axis. The geometrical analysis in the two views is sufficient to determine the constitutive law and the Poisson ratio of the membrane without a preliminary knowledge of the shear elastic modulus$G_{s}$. We conclude that the membrane of human serum albumin capsules obeys the generalized Hooke law with a Poisson ratio of 0.4. The shear elastic modulus is then determined by the combination of numerical and experimental variations of the Taylor parameter with the capillary number.
Tobacco Cessation in Economically Disadvantaged Dominican Republic Communities: Who are the Ex-Users?
Authors: Ossip Deborah J. , Quiñones Zahíra , Diaz Sergio , Thevenet-Morrison Kelly , Fisher Susan , Holderness Heather , Cai Xeuya , McIntosh Scott , Dozier Ann , Chin Nancy , Weber Emily , Sanchez Jose Javier , Bautista Arisleyda , Almonte Héctor 
Published: February 2015

Introduction: Tobacco use and its harm continue to increase in low and middle income countries (LMICs) globally. Smoking cessation is the most effective means of reducing morbidity and mortality from tobacco use. Increasing the prevalence of ex-users is an indicator of population cessation.Aims: This study provides the first examination of factors associated with ex-tobacco use status in the Dominican Republic (DR), a LMIC in the Latin America and Caribbean region.Methods: Baseline surveillance was conducted for 1,177 randomly selected households in seven economically disadvantaged DR communities (total N = 2,680 adult household members).Results: Ex-user prevalence was 10.6% (1.0%–18.5% across communities), 14.8% were current users (9.1–20.4), and quit ratios were 41.7% (9.7%–52.7%). Among ever users, females (OR 2.02, 95% CI 1.41, 2.90), older adults (45–64: OR 1.75, 95% CI 1.12, 2.74; 65+: OR 2.09, 95% CI 1.29, 3.39), and those who could read/write (OR 1.64, 95% CI 1.08, 2.50), had health conditions (OR 1.63, 95% CI 1.11, 2.41), and lived with ex-users (OR 1.70, 95% CI 1.12, 2.58) were over 60% to two times as likely to be ex-users. Those from remote communities (OR 0.52, 95% CI 0.36, 0.74), using chewed tobacco (OR 0.14, 95% CI 0.04, 0.48) and living with tobacco users (OR 0.55, 95% CI 0.37, 0.81) were less likely to be ex-users.Conclusions: Ex-user prevalence and quit ratios were lower than for high income countries. Implementing broad tobacco control measures, combined with clinically targeting vulnerable groups, may increase tobacco cessation to most effectively reduce this public health crisis.