bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stagnation Point Flow and Heat Transfer of a Magneto-Micropolar Fluid Towards a Shrinking Sheet with Mass Transfer and Chemical Reaction
Authors: Batool K. , Ashraf M. 
Published: January 2013

AbstractA comprehensive study of MHD two dimensional stagnation point flow with heat and mass transfer characteristics towards a heated shrinking sheet immersed in an electrically conducting incompressible micropolar fluid in the presence of a transverse magnetic field is analyzed numerically. The governing continuity, momentum, angular momentum, mass concentration and heat equations together with the associated boundary conditions are first reduced to a set of self similar nonlinear ordinary differential equations using a similarity transformation and are then solved by a method based on finite difference discretization. Some important features of the flow, heat & mass transfer characteristics and chemical reaction for different values of the physical parameters are analyzed, discussed and presented through tables and graphs. The study may be beneficial in the flow and heat control of polymeric processing.
Unsteady Boundary Layer Flow of Nanofluid Past an Impulsively Stretching Sheet
Authors: Mustafa M. , Hayat T. , Alsaedi A. 
Published: January 2013

AbstractThe unsteady laminar boundary layer flow of nanofluid caused by a linearly stretching sheet is considered. Transport equations contain the simultaneous effects of Brownian motion and thermophoretic diffusion of nanoparticles. The relevant partial differential equations are non-dimensionalized and transformed into similar forms by using appropriate similarity transformations. The uniformly valid explicit expressions of velocity, temperature and nanoparticles volume fraction are derived. Convergence of the series solutions is carefully analyzed. It is observed that an increase in the strength of Brownian motion effect rises the temperature appreciably. However rate of heat transfer and nanoparticles concentration at the sheet is reduced when Brownian motion effect intensifies. It is also found that the temperature and nanoparticles concentration are increasing functions of the unsteady parameter.
Isolation, identification and characterisation of three novel probiotic strains (Lactobacillus paracaseiCNCM I-4034,Bifidobacterium breveCNCM I-4035 andLactobacillus rhamnosusCNCM I-4036) from the faeces of exclusively breast-fed infants
Authors: Muñoz-Quezada Sergio , Chenoll Empar , María Vieites José , Genovés Salvador , Maldonado José , Bermúdez-Brito Miriam , Gomez-Llorente Carolina , Matencio Esther , José Bernal María , Romero Fernando , Suárez Antonio , Ramón Daniel , Gil Angel 
Published: January 2013

The aim of the present study was to isolate, identify and characterise novel strains of lactic acid bacteria and bifidobacteria with probiotic properties from the faeces of exclusively breast-fed infants. Of the 4680 isolated colonies, 758 exhibited resistance to low pH and tolerance to high concentrations of bile salts; of these, only forty-two exhibited a strong ability to adhere to enterocytesin vitro.The identities of the isolates were confirmed by 16S ribosomal RNA (rRNA) sequencing, which permitted the grouping of the forty-two bacteria into three different strains that showed more than 99 % sequence identity withLactobacillus paracasei,Lactobacillus rhamnosusandBifidobacterium breve, respectively. The strain identification was confirmed by sequencing the 16S–23S rRNA intergenic spacer regions. Strains were assayed for enzymatic activity and carbohydrate utilisation, and they were deposited in the Collection Nationale de Cultures de Microorganismes (CNCM) of the Institute Pasteur and namedL. paracaseiCNCM I-4034,B. breveCNCM I-4035 andL. rhamnosusCNCM I-4036. The strains were susceptible to antibiotics and did not produce undesirable metabolites, and their safety was assessed by acute ingestion in immunocompetent and immunosuppressed BALB/c mouse models. The three novel strains inhibitedin vitrothe meningitis aetiological agentListeria monocytogenesand human rotavirus infections.B. breveCNCM I-4035 led to a higher IgA concentration in faeces and plasma of mice. Overall, these results suggest thatL. paracaseiCNCM I-4034,B. breveCNCM I-4035 andL. rhamnosusCNCM I-4036 should be considered as probiotic strains, and their human health benefits should be further evaluated.
Impaired emotion regulation in schizophrenia: evidence from event-related potentials
Authors: Horan W. P. , Hajcak G. , Wynn J. K. , Green M. F. 
Published: January 2013

BackgroundAlthough several aspects of emotion seem to be intact in schizophrenia, there is emerging evidence that patients show an impaired ability to adaptively regulate their emotions. This event-related potential (ERP) study examined whether schizophrenia is associated with impaired neural responses to appraisal frames, that is when negative stimuli are presented in a less negative context.MethodThirty-one schizophrenia out-patients and 27 healthy controls completed a validated picture-viewing task with three conditions: (1) neutral pictures preceded by neutral descriptions (‘Neutral’), (2) unpleasant pictures preceded by negative descriptions (‘Preappraised negative’), and (3) unpleasant pictures preceded by more neutral descriptions (‘Preappraised neutral’). Analyses focused on the late positive potential (LPP), an index of facilitated attention to emotional stimuli that is reduced following cognitive emotion regulation strategies, during four time windows from 300 to 2000 ms post-picture onset.ResultsReplicating prior studies, controls showed smaller LPP in Preappraised neutral and Neutral versus Preappraised negative conditions throughout the 300–2000-ms time period. By contrast, patients showed (a) larger LPP in Preappraised neutral and Preappraised negative versus Neutral conditions in the initial period (300–600 ms) and (b) an atypical pattern of larger LPP to Preappraised neutral versus Preappraised negative and Neutral conditions in the 600–1500-ms epochs.ConclusionsModulation of neural responses by a cognitive emotion regulation strategy seems to be impaired in schizophrenia during the first 2 s after exposure to unpleasant stimuli.
Both low birthweight and high birthweight are associated with cognitive impairment in persons with schizophrenia and their first-degree relatives
Authors: Torniainen M. , Wegelius A. , Tuulio-Henriksson A. , Lönnqvist J. , Suvisaari J. 
Published: January 2013

BackgroundBoth low birthweight and high birthweight have been associated with an increased risk for schizophrenia and cognitive impairments in the general population. We assessed the association between birthweight and cognitive performance in persons with schizophrenia and their unaffected first-degree relatives.MethodWe investigated a population-based family sample comprising persons with schizophrenia (n = 142) and their unaffected first-degree relatives (n = 277). Both patients and relatives were interviewed with the Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV) and a comprehensive neuropsychological test battery was administered. Information on birthweight was obtained from obstetric records. We used generalized estimating equation (GEE) models to investigate the effect of birthweight, as a continuous variable, on cognitive functioning, adjusting for within-family correlation and relevant covariates.ResultsBoth low birthweight and high birthweight were associated with lower performance in visuospatial reasoning, processing speed, set-shifting and verbal and visual working memory among persons with schizophrenia and their unaffected first-degree relatives compared to individuals with birthweight in the intermediate range. The group × birthweight interactions were non-significant.ConclusionsBoth low birthweight and high birthweight are associated with deficits in cognition later in life. Schizophrenia does not seem to modify the relationship between birthweight and cognition in families with schizophrenia.
Liberal Art: Art and Education for Citizenship in Kant's Critique of Judgment
Authors: Donath Christian R. 
Published: January 2013

AbstractWhile most political theorists focus on the role of reflective judgment in Kant's Critique of Judgment, the political dimensions of art itself have been overlooked. Kant's treatment of art suggests a consistent political message: art, as an analogy, can teach basic values for citizenship. I examine his hierarchy of the arts, as well as his treatment of genius and taste, arguing that each is informed by Kant's belief in the heuristic capacity of art.
From “Political Theology” to “Political Religion”: Eric Voegelin and Carl Schmitt
Authors: Gontier Thierry 
Published: January 2013

In his workPolitics as Religion, Emilio Gentile credits Eric Voegelin with having invented, if not the expression itself, then at least the concept of “political religion” which the latter would use consistently throughout the 1960s to describe totalitarian regimes. In hisAutobiographical Reflections, drawn from an interview recorded in 1973, Voegelin revisits the use of this expression and gives an indication of the sources that inspired him to adopt it:When I spoke of thepolitischen Religionen, I conformed to the usage of a literature that interpreted ideological movements as a variety of religions. Representative of this literature was Louis Rougier's successful volume onLes Mystiques politiques.Besides the work by Louis Rougier, it is highly likely that Voegelin is thinking of the French Catholic “personalist” philosophers, such as Jacques Maritain, Henri de Lubac, and Joseph Vialatoux, who also interpreted the emerging totalitarian movements less in terms of social and political phenomena than as a profound spiritual disorder. These readings are also enriched by Bergson's work (which proved decisive for Voegelin)The Two Sources of Morality and Religion. It may appear surprising that Voegelin does not refer to the emblematic work by Carl Schmitt, thePolitical Theologyof 1922. Schmitt had also invented, if not a term, then at least a concept destined for a productive career. Moreover,Political Theologyand Voegelin'sPolitical Religions(1938) have similar objectives, namely, to show that all political doctrines involve a relationship between mankind and the sacred in one form or another—even (and perhaps especially) those that claim to have eliminated the religious element entirely.
A Liberal Pluralism: Isaiah Berlin and John Stuart Mill
Authors: Zakaras Alex 
Published: January 2013

AbstractThe essay explores the relationship between value pluralism, as Isaiah Berlin understood it, and liberalism. It consists of two main parts. In the first part, I argue that value pluralism does not entail liberalism, and I criticize two philosophers—William Galston and George Crowder—who believe that it does. In the second, I reconstruct and defend Isaiah Berlin's own understanding of this relationship, drawing on an essay that is often neglected by Berlin's interpreters: “John Stuart Mill and the Ends of Life.” Berlin thought that the relationship between value pluralism and liberalism was largely psychological. He believed that those who embraced value pluralism would be more likely to affirm liberal institutions, because they would be more likely to exhibit certain virtues—notably empathy, imagination, and openness to other ways of life—that typically motivate tolerance.
Characterization of Polymeric Microcapsules Containing a Low Molecular Weight Peptide for Controlled Release
Authors: Moore Keith , Amos Jennifer , Davis Jeffrey , Gourdie Robert , Potts Jay D. 
Published: January 2013

AbstractA need exists to prolong the release of rapidly metabolized peptides of a low molecular weight, while delivering this peptide without environmental interference. Previous studies have used bovine serum albumin (BSA) as a model peptide to study release characteristics from alginate microcapsules. BSA is 66 kDa in size, while the peptide of interest here, connexin-43 carboxyl-terminus mimetic peptide (αCT1), is only 3.4 kDa. Such a change in size results in a much different set of release parameters. Our overall goal is a sustained release over a 24+ h period. Prolonged application of the peptide to a wound site to investigate therapeutic effects is ideal. As a result, a diffusion method using alginate microcapsules, along with the addition of poly-l-lysine and poly-l-ornithine, has been explored. We first aimed to establish and characterize our parameters through a set of parametric tests. Variations in polymer coating, change in pH, and changes in loading ratio have previously been shown to effect release using model compounds. Here we test specific changes in these parameters to show effects on the release of αCT1. Additionally, the microcapsules were attached to several biomaterials and surgical implants by ultraviolet cross-linking to study the effectiveness of attachment and delivery. Analysis and measurements using phase contrast microscopy, scanning electron microscopy, and atomic force microscopy were used to characterize changes in microcapsule morphology.
Regulation of Bacillus subtilis DesK thermosensor by lipids
Authors: Martín Mariana , de Mendoza Diego 
Published: January 2013

Temperature sensing is essential for the survival of living cells. The membrane-bound thermosensor DesK from Bacillus subtilis is a key representative of histidine kinases receptors able to remodel membrane lipid composition when the temperature drops below ~30°C. Although the receptor is well studied, a central issue remains: how does the compositional and functional diversity of the surrounding membrane modulate receptor function? Reconstituting full-length DesK into proteoliposomes of well-defined and controlled lipid composition represents a minimal synthetic approach to systematically address this question. Thus DesK has been reconstituted in a variety of phospholipid bilayers and its temperature-regulated autokinase activity determined as function of fatty acyl chain length, lipid head-group structure and phase preference. We show that the head group structure of lipids (both in vitro and in vivo) has little effect on DesK thermosensing, whereas properties determined by the acyl chain of lipids, such as membrane thickness and phase separation into coexisting lipid domains, exert a profound regulatory effect on kinase domain activation at low temperatures. These experiments suggest that the non-polar domain of glycerolipids is essential to regulate the allosteric structural transitions of DesK, by activating the autophosphorylation of the intracellular kinase domain in response to a decrease in temperature.
Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function
Authors: Koole Cassandra , Pabreja Kavita , Savage Emilia E. , Wootten Denise , Furness Sebastian G.B. , Miller Laurence J. , Christopoulos Arthur , Sexton Patrick M. 
Published: January 2013

Type 2 diabetes is a major global health problem and there is ongoing research for new treatments to manage the disease. The GLP-1R (glucagon-like peptide-1 receptor) controls the physiological response to the incretin peptide, GLP-1, and is currently a major target for the development of therapeutics owing to the broad range of potential beneficial effects in Type 2 diabetes. These include promotion of glucose-dependent insulin secretion, increased insulin biosynthesis, preservation of β-cell mass, improved peripheral insulin sensitivity and promotion of weight loss. Despite this, our understanding of GLP-1R function is still limited, with the desired spectrum of GLP-1R-mediated signalling yet to be determined. We review the current understanding of GLP-1R function, in particular, highlighting recent contributions in the field on allosteric modulation, probe-dependence and ligand-directed signal bias and how these behaviours may influence future drug development.
Extracellular vesicles in the circulation: are erythrocyte microvesicles a confounder in the plasma haemoglobin assay?
Authors: de Vooght Karen M.K. , Lau Cedric , de Laat Pim P.M. , van Wijk Richard , van Solinge Wouter W. , Schiffelers Raymond M. 
Published: January 2013

Blood contains a mixture of extracellular vesicles from different cell types, primarily platelets, endothelial cells, leucocytes and erythrocytes. Erythrocytes are the most abundant cell type in blood and could, especially in certain pathologies, represent an important source of vesicles. Since erythrocytes contain the haemoglobin components iron and haem, which are potentially toxic, it is important to investigate the contribution of vesicle-associated haemoglobin to total cell-free haemoglobin levels. To our knowledge, this is the first time that cell-free plasma haemoglobin has been differentiated into vesicle-associated and molecular species. We investigated the contribution of vesicle-associated haemoglobin in residual patient material that was routinely analysed for total cell-free plasma haemoglobin. All patient samples included in the study were haemolytic with total cell-free haemoglobin concentration ranging from 80 to 2500 mg/l. In the majority of the samples, total cell-free haemoglobin concentration was between 100 and 200 mg/l. No haemoglobin could be detected in the vesicle fraction, indicating that the contribution of vesicle-associated haemoglobin to total cell free-haemoglobin levels in plasma is negligible. It is important to investigate whether erythrocyte vesicles are not formed in blood or that their production is not increased during pathologies associated with haemolysis or that the clearance rate of the vesicles surpasses the formation rate.
Mechanism and function of DHHC S-acyltransferases
Authors: Linder Maurine E. , Jennings Benjamin C. 
Published: January 2013

Protein S-palmitoylation is a reversible post-translational modification of proteins with fatty acids. In the last 5 years, improved proteomic methods have increased the number of proteins identified as substrates for palmitoylation from tens to hundreds. Palmitoylation regulates protein membrane interactions, activity, trafficking and stability and can be constitutive or regulated by signalling inputs. A family of PATs (protein acyltransferases) is responsible for modifying proteins with palmitate or other long-chain fatty acids on the cytoplasmic face of cellular membranes. PATs share a signature DHHC (Asp-His-His-Cys) cysteine-rich domain that is the catalytic centre of the enzyme. The biomedical importance of members of this family is underscored by their association with intellectual disability, Huntington's disease and cancer in humans, and raises the possibility of DHHC PATs as targets for therapeutic intervention. In the present paper, we discuss recent progress in understanding enzyme mechanism, regulation and substrate specificity.
Rovibrational internal energy transfer and dissociation of $\mathbf { \rm N_2(^1\Sigma _g^+)-\rm N(^4S_u)}$N2(1Σg+)−N(4Su) system in hypersonic flows
Authors: Panesi Marco , Jaffe Richard L. , Schwenke David W. , Magin Thierry E. 
Published: January 2013

A rovibrational collisional model is developed to study energy transfer and dissociation of \documentclass[12pt]{minimal}\begin{document}$\rm N_2(^1\Sigma _g^+)$\end{document}N2(1Σg+) molecules interacting with \documentclass[12pt]{minimal}\begin{document}$\rm N(^4S_u)$\end{document}N(4Su) atoms in an ideal isochoric and isothermal chemical reactor. The system examined is a mixture of molecular nitrogen and a small amount of atomic nitrogen. This mixture, initially at room temperature, is heated by several thousands of degrees Kelvin, driving the system toward a strong non-equilibrium condition. The evolution of the population densities of each individual rovibrational level is explicitly determined via the numerical solution of the master equation for temperatures ranging from 5000 to 50 000 K. The reaction rate coefficients are taken from an ab initio database developed at NASA Ames Research Center. The macroscopic relaxation times, energy transfer rates, and dissociation rate coefficients are extracted from the solution of the master equation. The computed rotational-translational (RT) and vibrational-translational (VT) relaxation times are different at low heat bath temperatures (e.g., RT is about two orders of magnitude faster than VT at T = 5000 K), but they converge to a common limiting value at high temperature. This is contrary to the conventional interpretation of thermal relaxation in which translational and rotational relaxation timescales are assumed comparable with vibrational relaxation being considerable slower. Thus, this assumption is questionable under high temperature non-equilibrium conditions. The exchange reaction plays a very significant role in determining the dynamics of the population densities. The macroscopic energy transfer and dissociation rates are found to be slower when exchange processes are neglected. A macroscopic dissociation rate coefficient based on the quasi-stationary distribution, exhibits excellent agreement with experimental data of Appleton et al. [J. Chem. Phys. 48, 599–608 (1968)]10.1063/1.1668690. However, at higher temperatures, only about 50% of dissociation is found to take place under quasi-stationary state conditions. This suggest the necessity of explicitly including some rovibrational levels, when solving a global kinetic rate equation.
Stick-slip friction and wear of articular joints
Authors: Lee Dong Woog , Banquy Xavier , Israelachvili Jacob N. 
Published: January 2013

Significance
The goal of this study was to use the Surface Forces Apparatus to examine the effects of slip-stick friction on cartilage surface morphology under different loading and sliding conditions. Different load and speed regimes were represented using friction maps that separated regimes of smooth and stick-slip sliding. The finding of this work is that damage generally occurs within the stick-slip regimes and is not directly related to the friction coefficient. Prolonged exposure of cartilage surfaces to stick-slip sliding resulted in a significant increase of surface roughness, indicative of severe morphological changes (damage) of the cartilage surfaces.
Why does the Jeans Swindle work?
Authors: Falco M. , Hansen S. H. , Wojtak R. , Mamon G. A. 
Published: January 2013

Abstract
When measuring the mass profile of any given cosmological structure through internal kinematics, the distant background density is always ignored. This trick is often referred to as the ‘Jeans Swindle’. Without this trick a divergent term from the background density renders the mass profile undefined; however, this trick has no formal justification. We show that when one includes the expansion of the Universe in the Jeans equation, a term appears which exactly cancels the divergent term from the background. We thereby establish a formal justification for using the Jeans Swindle.