bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of mycotoxins, mycobiota and toxigenic fungi in the traditional medicine Radix Dipsaci
Authors: Hu Min , Wang Lulu , Su Dapeng , Yuan Qingsong , Xiao Chenghong , Guo Lanping , Wang Meidan , Kang Chuanzhi , Zhou Tao , Zhang Jinqiang 
Published: July 2024

Abstract

Radix Dipsaci is commonly utilized in traditional Chinese medicine and is susceptible to contamination with mycotoxins. Here, we evaluated the mycotoxins, mycobiota and toxigenic fungi in the traditional medicine Radix Dipsaci. Among the sixty-three batches of Radix Dipsaci samples, we found that a total of twenty-eight batches (44.4%) were contaminated with mycotoxins including AFB1, AFG1, OTA, ZEN, AFG2 and T-2. More than 60% of the contaminated samples were combined with multiple mycotoxins. Fungal diversity and community were altered in the Radix Dipsacicontaminated with various mycotoxins. The abundance of Aspergillus and Fusariumincreased in the Radix Dipsacicontaminated with aflatoxins and ZEN. A total of ninety-five strains of toxigenic fungi were isolated from the samples contaminated with mycotoxins, predominantly comprising Aspergillus (73.7%), Fusarium (20.0%), and Penicillium (6.3%). Through morphological identification, molecular identification, mycotoxin synthase gene identification and toxin production verification, we confirmed that AFB1 and AFG1 derive from A. flavus, OTA derives from A. westerdijkiae, ZEN derives from F. oxysporum, and T-2 derives from F. graminearum in Radix Dipsaci. These data may help to provide useful information for effective prevent, control, and degrade contaminants strategies to ensure the safety of traditional medicine Radix Dipsaci.
Social influences complement environmental cues to stimulate migrating juvenile salmon
Authors: Kururvilla Maria , Quinn Thomas P. , Anderson Joseph H. , Scheuerell Mark D. , Miller Erika M. , Berger Andrew G. , Okasaki Connie , McMillan John R. , Pess George R. , Westley Peter A.H. , Berdahl Andrew M. 
Published: July 2024

Abstract

Background
The large-scale seasonal migrations undertaken by many species require complex navigational and timing decisions. Animals migrating in groups might benefit from collective decision making, especially if the environment is noisy (i.e., has high degree of local variation rather than smooth gradients in, for example, salinity or temperature), unpredictable, or the migrants cannot rely on individually acquired information. We focus on juvenile salmon whose migration from fresh water to the ocean is timed to match suitable conditions for growth and survival. While the environmental and physiological factors that influence the timing of migration have been well studied, the influence of social interactions on migration timing is poorly understood.
Method
We compiled juvenile salmon data, collected at trap over 19 years, during their downstream seaward migration in three rivers in Washington state along with a suite of relevant environmental time series. We developed state space statistical models to estimate the influence of hatchery-produced salmon to stimulate the downstream migration of wild salmon, while also incorporating potential environmental stimuli.
Results
Our results are consistent with the “pied-piper” hypothesis that large numbers of migrating hatchery-origin salmon provide a social cue stimulating migration of co-occurring wild salmon. The number of hatchery salmon counted at the trap was a strong predictor of the number of wild sub-yearling Chinook salmon in the Dungeness and Puyallup rivers and on yearling coho salmon in the Puyallup and Skagit rivers. Migration timing was also influenced by a suite of physical factors related to temperature, river flow, photoperiod, and lunar phase.
Conclusions
Our findings highlight the potential for social cues to affect migration timing of downstream migrating salmon, in concert with environmental factors. Incorporating social information into timing decisions may allow animals to benefit from collective decision making strategies and better time their migrations. Moreover, understanding the effects of large-scale hatchery releases on wild salmon migration may provide valuable insights for planning the timing and duration of hatchery releases.
The diagnostic value of a hybrid quantitative flow ratio–FFR strategy for ischemia-causing stenosis in patients with unstable angina and its impact on revascularization strategy
Authors: XIAO Yanan , Xiao Wentao , YE Famin , GUO Suping , ZHANG Jingjing , QU Yongsheng , Liu Xiaoqing , Zhang Jing , Chuanyu GAO 
Published: July 2024

Abstract

Quantitative flow fraction (QFR) is a functional test without a guide wire based on coronary angiography. In this study, flow reserve fraction (FFR) was used as the reference standard to verify the diagnostic value of QFR in patients with unstable angina pectoris with critical coronary artery disease (coronary artery stenosis degree of 40%-70%) functional stenosis, and to evaluate the effect of fusion strategies of QFR-FFR on revascularization strategies in such patients.This retrospective study included patients with unstable angina pectoris who were admitted to Fuwai Central China Cardiovascular Hospital from June 1, 2018 to June 1, 2023 and underwent coronary flow reserve fraction examination. QFR values of target vessels were analyzed offline by AngioPlus (Shanghai Pulsation Medical Imaging Technology Co., LTD.), the second-generation QFR detector, and anatomical parameters of the diseased vessels were recorded as follows: minimal luminal diameter (MLD), percent diameter stenosis (DS%), minimal luminal area (MLA), percent area stenosis (AS%). Functional coronary artery stenosis is defined as FFR≤0.80. Using FFR as the gold standard, the AUC values of contrast-flow QFR (cQFR) and fixed-flow QFR (fQFR) for identifying functional coronary artery stenosis in patients with unstable angina pectoris were 0.832（95%CI：0.772~0.892，P=0.000）and 0.817（95%CI：0.756~0.877，P=0.000）, respectively. The diagnostic accuracy, sensitivity and specificity of cQFR and fQFR were 85.52%、78.57%、89.78% and 79.19%、75.00%、81.75%, respectively. Delong test showed that there was no significant difference between cQFR and fQFR in the diagnostic value of functional stenosis in patients with unstable angina. When in the QFR "gray zone" (0.77 to 0.87), compared with fQFR, cQFR had a higher AUC for diagnosing coronary critical lesion functional stenosis in patients with unstable angina pectoris (0.881 vs 0.705). Furthermore, a fusion strategy using cQFR-FFR avoided invasive FFR measurements in 71.49% of patients. With FFR as the gold standard, QFR has a certain diagnostic value for coronary artery critical lesion functional stenosis in patients with unstable angina pectoris. When QFR is in the "gray area", the diagnostic value of cQFR is higher. At this time, the fusion strategy of cQFR-FFR can avoid FFR measurement in some patients.
C-reactive protein flare-response predicts the efficacy of PD-1/PD-L1 monoclonal antibodies in metastatic gastric cancer
Authors: Lei YiHui , Lin Li , Wang Yayue , Chen Weiping , Liu Guoyan 
Published: July 2024

Abstract

Currently, predictive biomarkers for the efficacy of immunotherapy in metastatic gastric cancer (mGC) during the era of immune checkpoint inhibitorsare still under evaluation. This retrospective study investigated the predictive value of early C-reactive protein (CRP) kinetics on the efficacy of programmed cell death protein-1(PD-1)/programmed cell death ligand 1 (PD-L1)monoclonal antibody treatment in mGC. A total of 42 mGC patients included in this study, who treated with PD-1/PD-L1 monoclonal antibodies between 2019 and 2022. Based on early CRP kinetics, patients were categorized into three groups: CRP flare-responders: those whose CRP levels increased to more than twice the baseline within one month of initiating PD-1/PD-L1 monoclonal antibodies and then decreased to below baseline within three months; (2) CRP responders: those whose CRP levels decreased by ≥30% within three months of treatment; (3) non-CRP responders: the remaining patients. The objective response rates for CRP flare-responders, CRP responders, and non-CRP responders were 57.1%, 26.6%, and 7.7%(p=0.042), respectively. The median overall survivals (OS) of the CRP flare-responder, CRP responder, and non-CRP responder groups were not reached, not reached, and 11.9 months(p=0.006), respectively. The median progression-free survivals (PFS) of the CRP flare-responder, CRP responder, and non-CRP responder groups were not reached, 8 months, and 4.5 months (p=0.003), respectively. Multivariate analysis revealed that early CRP kinetics were independent predictors of objective response (p=0.033), OS (p=0.026), and PFS (p=0.004). Our study showed that in mGC patients receiving PD-1/PD-L1 monoclonal antibody therapy, CRP flare-response was associated with significant tumor shrinkage and improved survival outcomes. Early CRP kinetics have predictive value for the therapeutic efficacy of PD-1/PD-L1 monoclonal antibodies.
Efficacy and Safety of Two Simplified Regional Citrate Anticoagulation for Intermittent Hemodialysis: A Randomized Cross-over Trial
Authors: Yuan Shizhu , Tao Mei , Tu Qiudi , Shen Huajuan , Zhou Meiling , Jia Yanqing , He Qiang , Liu Yueming , Shen Xiaogang 
Published: July 2024

Abstract

In recent years, due to the low risk of bleeding, regional citrate anticoagulation (RCA) is being tried for intermittent hemodialysis (IHD). Simplified regional citrate anticoagulation (S-RCA) has been attempted in IHD. This randomized cross-over trial was designed to compared the efficacy and safety of two RCAs in heparin-free dialysis patients, which were named S-RCA and two-stage simplified regional citrate anticoagulation (TS-RCA). In summary, the anticoagulation effect of TS-RCA is better than that of S-RCA in IHD, especially in the anticoagulation of venous bubbles trap. And these two RCAs were safe for IHD patient with high bleeding risk. Trial Registration: Chinese Clinical Trial Registry (CHICTR): Registration Number ChiCTR2000034314; Registration date 28 September 2020.
“What if the patient has a severe reaction, and it is my fault?” A qualitative study exploring factors for sustainable implementation of penicillin allergy delabelling.
Authors: Alnæs Marie Bjørbak , Skodvin Brita , Jahnsen Jan Anker , Velure Grete Kalleklev , Oppegaard Oddvar , Kittang Bård Reiakvam , Storaas Torgeir , Schaufel Margrethe Aase 
Published: July 2024

Abstract

Background
Penicillin allergy delabelling (PAD) is a key target in antibiotic stewardship, but uptake of the procedure outside clinical studies is limited. We aimed to explore factors that need to be addressed to sustainably implement a clinical pathway for PAD.
Methods
We conducted a qualitative study based on semi-structured interviews with focus groups consisting of a purposive sample of twenty-five nurses and physicians working on three different hospitals in Western Norway. Systematic text condensation was applied for analysis.
Results
Psychological safety was reported as crucial for clinicians to perform PAD. A narrative of uncertainty and anticipated negative outcomes were negatively associated with PAD performance. Education, guidelines, and colleague- and leadership support could create psychological safety and empower health personnel to perform PAD. Key factors for sustainable implementation of PAD were to facilitate the informant’s profound motivation for providing optimal health care and for reducing antimicrobial resistance. Informants were motivated by the prospect of a simplified PAD procedure.
We identified three main needs for implementation of PAD: 1) creating psychological safety; 2) utilising clinicians’ inherent motivation and 3) optimal organisational structures.
Conclusion
A planned implementation of PAD must acknowledge clinicians’ need for psychological safety and aid reassurance through training, leadership, and guidelines. To implement PAD as an everyday practice it must be minimally disruptive and provide a contextually adaptive logistic chain. Also, the clinician’s motivation for providing the best possible healthcare should be utilised to aid implementation. The results of this study will aid sustainable implementation of PAD in Norway.
A systematic review and meta-analysis protocol on low back pain prevalence and associated factors among nurses in Ethiopia
Authors: Bitew Sintayehu Tsegaye , Mekonnen Yeshiwas Genanaw , Gutema Olantu Mekonnen 
Published: July 2024

Abstract

Introduction: Nurses frequently experience low back pain (LBP), which is a serious health problem that impairs both their physical and occupational well-being.
Objective: To review and synthesis the prevalence and associated factors of Low Back Pain among Nurses in Ethiopia.
Method: Databases such as PubMed, EMBASE and Google scholar will be searched. Inclusion criteria included articles with prevalence of LBP and associated factors among Nurses in Ethiopia. The keywords “prevalence, associated factors, low back pain, nurses”, and “Ethiopia” will be used as part of this search. For data extraction, a form will be designed that included the following variables: Author names, sample size, age, gender, marital status, work experience, body mass index, job type, smoking status, year of publication, type of standard questionnaire, prevalence of LBP, studies’ quality score and associated factors. Data analysis will be carried out using random effects model. Heterogeneity between studies will be assessed by using the I2 and Q tests. This review will be reported following the PRISMA Guidelines for Meta- Analysis and Systematic Reviews of Observational Studies.
Discussion: This systematic review and meta-analysis will be among the first to thoroughly examine and consolidate the available evidence on the prevalence and factors associated with Low Back Pain among Nurses in Ethiopia. The study's findings will guide future research and offer practitioners and clinicians insights into the nature and consequences of workplace injuries among nurses, suggesting appropriate interventions.
Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42024552833)
Metal-organic framework-covered stainless steel mesh as a novel heterogeneous catalyst in multi-component reaction
Authors: Hojati Seyedeh Fatemeh , Amiri Amirhassan , Kasraeian Maryam 
Published: July 2024

Abstract

The stainless steel mesh was covered by MOF-199 and applied in the four-component synthesis of 2-aminospiro[indeno[1,2-b]quinoxalin-11,4-pyran]-3-carbonitriles as a novel and efficient heterogeneous catalyst. The preparation of MOF-199-covered stainless steel mesh (MOF-199@SSM) was confirmed by FT-IR and FE-SEM analyses. MOF-199@SSM catalyst can be easily separated from the reaction mixture by simple forceps and reused. The stability of the catalyst was examined using a hot filtration test and no leaching occurred during the reaction. The reactions conditions were mild and the reaction times were relatively short. No by-product was produced, so, high purity and high yields of products were obtained
Association between biological aging and Asthma-COPD overlap based on Nhanes 2005-2018
Authors: Sun Tongyao , Yang Shengzhen , Li Shitao , Li Huiwen , Yu Jianjian , Wang Jun 
Published: July 2024

Abstract

BACKGROUND
Aging is an important factor in the pathogenesis of various respiratory diseases, and biological aging can better reflect the systemic functional status of individual organisms. The purpose of this study was to analyze the association between biological aging and Asthma-COPD Overlap (ACO) ,and to explore its potential causal relationship.
METHODS
The present study utilized data from the National Health and Nutrition Examination Survey (NHANES), spanning from 2005 to 2018. Three biological ages [Klemera-Doubal method (KDM), phenotypic age (PhenoAge) and homeostatic dysregulation (HD)] and two measures of biological acceleration of aging (BioAgeAccel and PhenoAgeAccel) were selected as the main exposure factors for analysis. Weighted logistic regression and restricted cubic spline regression were used to analyze the association between biological aging and ACO.
RESULTS
In our study, phenotypic age was positively associated with the incidence of ACO, and the degree of phenotypic age acceleration was also a risk factor for ACO prevalence. After further adjustment for demographic characteristics, both remained an important risk factor for ACO.
CONCLUSION
This study provides some evidence for the association of biological aging in the development of ACO. In addition, preventive strategies targeting aging have a potential role in reducing the risk of ACO.
Comparison of recent clinical outcomes of two different surgical procedures for the treatment of single-segment lumbar disc herniation
Authors: wang yewei , du yibin 
Published: July 2024

Abstract

Objective To investigate the recent clinical efficacy of UBED (unilateral two-channel endoscopic disc extraction) and MIS-TLIF (minimally invasive transforaminal approach lumbar interbody fusion) treatment for the treatment of single-segment lumbar disc herniation (LDH). Methods Seventy-three patients with single-segment LDH admitted to the First People's Hospital of Hefei City from December 2019 to January 2022 were selected for the study, and were divided into UBED and MIS-TLIF (Observation Group and Control Group), with 43 and 30 patients in each group, and patients in both groups had the degree of pain (measured by VAS scores) and dysfunction (measured by ODI scores) before and after the operation, functional status of the lumbar spine (measured by JOA score). In addition, some key indicators of the surgical procedure, such as the number of fluoroscopies, operative time, and bleeding, as well as the postoperative recovery, including CRP on the first postoperative day, time to get out of bed, hospitalization time and cost, intervertebral space height of the responsible segments at 3 months postoperatively, vertebral body slippage distances above and below the responsible segments, and the incidence of postoperative complications were also recorded.
Results At one month and three months after operation, the VAS score and ODI score of patients in both groups were lower than those before operation, and the difference was statistically significant (P<0.05). The difference in the incidence of postoperative complications was not statistically significant in the observation group compared with the control group (P>0.05). The VAS and ODI scores, number of intraoperative fluoroscopies, operation time, intraoperative bleeding, CRP on the first postoperative day, time to get out of bed, hospitalization time, hospitalization cost, and vertebral body slip distance above and below the responsible segment in the three months after surgery of the patients in the observation group were lower than those of the control group, and the differences were statistically significant (P<0.05).
Conclusion Both UBED and MIS-TLIF can reduce patients' low back and leg pain and dysfunction, and compared with MIS-TLIF, UBED has significant advantages in improving the treatment effect, shortening the operation time, reducing the number of fluoroscopies, the amount of intraoperative bleeding, and reducing the economic burden, but MIS-TLIF is conducive to the improvement of the lumbar spine stability and lumbar spine function.
Identifying Optimal Serum 1,3-β-D-Glucan Cut-off for Diagnosing Pneumocystis jirovecii Pneumonia in non-HIV Patients in the Intensive Care Unit
Authors: Li Yuan-Yuan , Chen Yan , Li Shan , Dong Run , Yang Qi-Wen , Peng Jin-Min , Du Bin 
Published: July 2024

Abstract

Background
Serum (1,3)-β-D-glucan (BDG) detection for diagnosis of Pneumocystis jirovecii pneumonia (PJP) in non-human immunodeficiency virus (HIV) immunocompromised patients lacks intensive care unit (ICU)-specific data. We aimed to assess its performance and determine the optimal cutoff for PJP in ICU population.
Methods
This retrospective study included critically ill non-HIV immunocompromised patients admitted to a medical ICU with suspected pneumonia, undergoing simultaneous microbiological testing for P. jirovecii on lower respiratory tract specimens and serum BDG. Confounders affecting BDG positivity were explored by multivariable logistic regression. Optimal cut-offs were derived from Youden's index for the entire cohort and subgroups stratified by confounders. Diagnostic performance of serum BDG was estimated at different cutoffs.
Results
Of 400 patients included, 42% were diagnosed with PJP and 58.3% had positive serum BDG. Serum BDG’s area under the receiver operating characteristic curve was 0.90 (0.87–0.93). At manufacturer's 150 pg/ml cut-off, serum BDG had high sensitivity and negative predictive value (94%), but low specificity and positive predictive value (67%). Confounders associated with a positive serum BDG in PJP diagnosis included IVIG infusion within 3 days (odds ratio [OR] 9.24; 95% confidence interval [CI] 4.09–20.88, p < 0.001), other invasive fungal infections (OR 4.46; 95% CI 2.10–9.49, p < 0.001) and gram-negative bacteremia (OR 29.02; 95% CI 9.03–93.23, p < 0.001). The application of optimal BDG cut-off values determined by Youden's index (252 pg/ml, 390 pg/ml, and 202 pg/ml) specific for all patients and subgroups with or without confounders improved the specificity (79%, 74%, and 88%) and corresponding PPV (75%, 65%, and 85%), while maintaining reasonable sensitivity and NPV.
Conclusions
Tailoring serum BDG cutoff specific to PJP and incorporating consideration of confounders could enhance serum BDG’s diagnostic performance in the ICU settings.
Numerical Simulation of Three-dimensional Seepage Field in a Tailing Pond under Multiple Operating Conditions
Authors: Fu Botao , Pei Jingjing , Ji Huaijun 
Published: July 2024

Abstract

Establishing strong seepage stability for tailings dams is crucial for ensuring their safety and mitigating the risk of failure. This study developed a three-dimensional seepage numerical model using finite element numerical computation for four different elevation conditions (5070 m, 5081 m, 5159 m, and 5213 m) encompassing the pond area and dam body. Seepage calculations were conducted under normal and flooding conditions, and the tailings pond’s seepage stability was assessed for various stacking scenarios. The spatial distribution pattern of the infiltration surface and the hydraulic stability of the tailings pond were evaluated, which provides insights into the three-dimensional infiltration stability. Examining the seepage stability under different accumulation conditions revealed distinct spatial distribution patterns of the infiltration surface and hydraulic ratio drop values. The findings indicated that the maximum permeability slope at 5070 m elevation ranged from 0.66 to 0.75 at normal operation water level and maximum flood level. Most hydraulic ratio drop values at 5081 m were below 0.2, while the anti-seepage lining sections at 5159 m and 5213 m showed larger values, and maintained the overall hydraulic ratio drop within safe limits. Consequently, the dam body's permeability was deemed secure, and no infiltration damage was anticipated with the proposed design of seepage control and drainage facilities. Moreover, sensitivity analysis of the tailing sand's permeability coefficient demonstrated that variations between 0.2 and 5 times the given parameter align with the seepage control requirements for the tailings dam. Additionally, local geomembrane breakage was found to have minimal impact on the tailing pond's seepage field and the dam body's permeability stability, which provides a scientific foundation for analyzing and designing the seismic static-dynamic stability of the tailings pond.