bluuebunny/crossref_metadata_2025_split huggingface dataset:
The hepatoprotective role of the aqueous extract of ginger against the harmful effects of paracetamol in rats
Authors: Abd-ALHassan Jameela 
Published: June 2024

This study was performed to determine the hepatoprotectiveactivities of watery extract of ginger in hepatotoxicityinduced by paracetamolin albino rats. Twenty fourrats were used and divided randomly into four equal groups each of which contain six animals, the first one was served as control, received nomal saline only, the second group werereceived paracetamol at a single dose of 3g/kg/B.W orally to induce hepatotoxicity, and the third and fourth groupsreceived watery extract of ginger at a dose 200 mg/Kg & 400 mg/Kg B.W orally once daily for 3 days respectivelyfollowed by administration of single dose of paracetamol 3 g/Kg B.Wafter 30 minute after extracts administration. Liver functions were assessed by estimating serumalanine amino transferase (ALT) , aspartate amino transferase (AST) , alkaline phosphatase (ALP), total serum bilirubin & total serum protein & albumin . The results revealed that the use of genger extracts at each dose ( 200 mg/Kg , 400 mg/Kg B.W) produced significant reduction in the level of these enzymes , total bilirubin while caused significant increase in the levels of total serum protein & total serum albumin , so the use of ginger extracts possess hepatoprotective activity by restoring the normal hepatic functions and potentiating the bio- defense system of the liver against hepatotoxicity produced by paracetamol administration .
Iras y resistencias de larga duraci&oacute;n en el Pac&iacute;fico colombiano:&nbsp;Los paros c&iacute;vicos de Buenaventura y Quibd&oacute; (1964-2017)
Authors: Parrado Pardo Erika Paola , Jaramillo Marín Jefferson 
Published: June 2024

Abstract: Anger and long-lasting resistances in the Colombian Pacific Civil: Strikes in Buenaventura and Quibdó (1964-2017)
In May 2017, two civic strikes occurred in Buenaventura and Quibdó, Colombia. Amid large cycles of global protest, these contentious collective actions demonstrated, once again, the failure of state promises made for decades to the inhabitants of the Colombian Pacific region. Based on historical-sociological information, we used qualitative-discursive analysis of archival sources, databases, and secondary material, as well as critical Latin American perspectives, to seek to carry out a processual and relational reading of social protest in the Pacific between 1964 and 2017. Our main conclusion is that the various events and struggles that took place during these 53 years constituted moments of historical, political, and cultural condensation of localized, micropolitical, and communal anger and resistance, from which some key challenges appear for the Pacific region and the country.
Resumen
En mayo de 2017 acontecieron dos paros cívicos en Buenaventura y Quibdó, Colombia. En medio de grandes ciclos de protesta global, estas acciones colectivas contenciosas evidencia-ron, una vez más, el fracaso de las promesas estatales realizadas por décadas a los habitantes de la región del Pacífico colombiano. A partir de una indagación de corte histórico-sociológico, donde empleamos el análisis cualitativo-discursivo de fuentes de archivo, de ba-ses de datos y de material secundario, así como perspectivas críticas latinoamericanas, busca-mos realizar una lectura procesual y relacional de la protesta social en el Pacífico, entre 1964 y 2017. Nuestra principal conclusión es que los diversos eventos y luchas que tuvieron lugar durante estos 53 años constituyeron momentos de condensación histórica, política y cultural de iras y resistencias lugarizadas, micropolíticas y comunales, de los cuales derivan algunos desafíos centrales para la región del Pacífico y el país.
The Moderating Effect of Vertical Agency Crisis on the Relationship Between Corporate Governance and Financial Performance in Nigeria
Authors: Emovon Felix Osayabor , Josiah Mary , Ozele Clement 
Published: June 2024

This study examines the moderating effect of vertical agency crises on the relationship between corporate governance mechanism and financial performance in Nigeria covering 2013 to 2022. To achieve this purpose, this study used precise proxies for the dependent, independent and moderator variables of interest. Based on a descriptive and ex-post facto research design, this study analyzed a set of panel data sourced from annual financial reports of eighteen (18) consumer goods firms drawn from a population of twenty-five (25) listed consumer goods firms in Nigeria. Mixed effect multi-level regression analysis estimator together with moderated regression analysis technique were employed to test the hypotheses after meeting necessary conditions for obtaining non-spurious least square regression estimates. The findings show that board ownership has a statistically significant relationship with financial performance, but board size, board independence and board gender diversity have insignificant relationship. Further, the findings from this study reveals among others that vertical agency crises have an insignificant moderating effect on the relationship between board independence and financial performance, the moderating effect is significantly positive in relation to board gender diversity for listed consumer goods firms in Nigeria . But for the variable of board size and board ownership, the moderating effect of vertical agency crises was seen to be statistically insignificant. Therefore, on the bases of the findings, this study suggests that managers should focus on mitigating vertical agency crises while concurrently strengthening board independence.
Antisipasi Konsumsi Minuman Keras dan Narkotika di Kalangan Remaja dengan Meningkatkan Minat Mini Soccer di Teluk Kabung Selatan
Authors: Khatimah Husnil , Haffizah Haffizah , Ramadhani Hurul Aini 
Published: June 2024

Tujuan pengabdian yang dilakukan adalah meningkatkan minat olahraga pada remaja di Teluk Kabung Selatan dalam rangka antisipasi minuman keras dan narkotika. Metode yang digunakan adalah pendekatan kualitatif dengan melakukan pengabdian kepada masyarakat yaitu PAR (Participatory Action Research) dengan tahapan kegiatan tanya jawab seputar minuman keras dan narkotika, pelatihan mini soccer, perlombaan mini soccer, dan penutupan kegiatan Teluk Kabung Selatan (Tekasel) Cup. Kegiatan Tekasel Cup diikuti oleh 8 club bola dengan menggunakan sistem gugur. Pengabdian yang dilakukan menunjukkan hasil bahwa program Tekasel Cup mampu mengantisipasi konsumsi narkoba dan minuman keras bagi para remaja dan masyarakat dengan jumlah peserta 72 orang dengan kisaran umur 16-25 tahun. Sebanyak 82% remaja mengalami peningkatan pemahaman dan pengetahuan tentang mini soccer, 71% mengalami peningkatan pemahaman dan pengetahuan tentang bahaya miras dan narkotika dan sebanyak 90% remaja sadar akan manfaat olahraga dan bahaya narkoba.
PENGARUH PENGEMBANGAN KARIR, IKLIM ORGANISASI DAN MOTIVASI TERHADAP KINERJA PEGAWAI DINAS PENGELOLAAN SUMBER DAYA AIR KABUPATEN SIDENRENG RAPPANG
Authors: Haeranah Haeranah , Maryadi Maryadi , Setiawan Irfan , Herni Herni 
Published: June 2024

Penelitian ini bertujuan untuk mengkaji pengaruh pengembangan karir, iklim organisasi dan motivasi terhadap kinerja pegawai Dinas Pengelolaan Sumber Daya Air Kabupaten Sidenreng Rappang. Penelitian ini menggunakan metode kuantitatif. Penelitian dilaksanakan di Dinas Pengelolaan Sumber Daya Air Kabupaten Kabupaten Sidenreng Rappang. Adapun data yang digunakan adalah data primer dan data sekunder yang diperoleh dari teknik menyebarkan kuesioner kepada 52 responden. Hasil penelitian menunjukkan bahwa variabel Pengembangan karir berpengaruh negatif terhadap kinerja pegawai dengan nilai t-hitung <t-tabel sebesar (-0,174 < 2,009) dan nilai sig.t (0,862 >0,05), pada variabel Iklim organisasi berpengaruh positif dan signifikan terhadap variabel kinerja pegawai dengan nilai t-hitung > t-tabel ( 4.131 > 2.009) dan nilai sig.t (0,000 < 0,05) pada variabel ketiga yaitu motivasi berpengaruh positif dan signifikan terhadap kinerja pegawai karena t-hitung .>.tabel ( 3.443 < 2.009) dan nilai signifikan (0,001 < 0,05). Pada uji simultan berpengaruh positif dan sign terhadap kinerja pegawai, karena nilai F-hitung > F-tabel ( 34.439 > 2.80) dengan signifikan, F sebesar (0,000 < 0,05)sedangkan uji determinasi mempunyai kontribusi terhadap kinerja pegawai sebesar 68,3%, sedangkan sisanya dipengaruhi oleh variabel lain yang tidak termasuk dalam penelitian.
Encapsulation protocol for fecal microbiota transplantation
Authors: Sipos Dávid , Varga Adorján , Kappéter Ágnes , Halda-Kiss Bernadett , Kása Péter , Pál Szilárd , Kocsis Béla , Péterfi Zoltán 
Published: June 2024

IntroductionClostridioides difficile infections (CDI) continue to pose a challenge for clinicians. Fecal microbiota transplantation (FMT) is an effective treatment option in CDI. Furthermore, recent and ongoing studies suggest potential benefits of FMT in other diseases as well.MethodsWe would like to present a novel protocol for encapsulation of lyophilized fecal material. Our method provides with better compliance as well as improved flexibility, storage and safety.ResultsFMT was conducted in 28 patients with an overall success rate of 82,14% using apsules containing lyophilized stool. 16 of patients were given capsules with lessened bacteria counts. The success rate in this group was 93,75%.DiscussionThe results highlight the still unanswered questions about the mechanism of action and contribute to a wider use of FMT in the clinical praxis and in research.
Assessing the risk of reoperation for mild pulmonary vein obstruction post-TAPVC repair: a retrospective cohort study
Authors: Alifu Ailixiati , Wang Haifan , Chen Renwei 
Published: June 2024

ObjectiveThis study investigates the impact of mild pulmonary vein obstruction, detected via echocardiography before hospital discharge, on the likelihood of reoperation in patients who have undergone repair for Total Anomalous Pulmonary Venous Connection (TAPVC).MethodUtilizing a single-center, retrospective cohort approach, we analyzed 38 cases from October 2017 to December 2023, excluding patients with functionally univentricular circulations or atrial isomerism. Our primary outcome was the necessity for reoperation within one year due to anatomical issues related to the initial TAPVC repair. Mild obstruction was defined as a pulmonary vein flow velocity ≥1.2 m/s.ResultOur findings revealed that 31.6% of patients exhibited pre-discharge mild obstruction. During the median follow-up of 10 months, reoperations were notably higher in the mild obstruction group compared to the normal group, with a significant association between pre-discharge mild obstruction and increased risk of reoperation. Specifically, in the fully adjusted model, mild obstruction was linked to a 13.9-fold increased risk of reoperation.ConclusionOur results suggest that a pre-discharge echocardiography Doppler velocity threshold of 1.2 m/s could serve as a critical predictor for reoperation, emphasizing the need for targeted follow-up strategies for at-risk patients.
Gonadal hormones and metabolic syndrome in middle-aged and elderly males: results from a prospective cohort study in China
Authors: Zhang Zhuo , Chen Yingna , Li Na , Huang Chulin , Lin Diaozhu , Wang Chengzhi , Wang Chunying , You Lili , Li Lingling , Li Fangping , Liang Ying , Xiao Huisheng , Yan Li , Lao Guojuan , Sun Kan 
Published: June 2024

BackgroundResearch has shown that gonadal hormones are involved in metabolic pathways relevant to metabolic syndrome (MetS). Nevertheless, no longitudinal study has been conducted on the association between SHBG and MetS in Chinese. The objective of our study was to determine whether there is any association between middle-aged and elderly males in China.MethodsA total of 531 eligible male subjects, aged above 40 years or older, without MetS at baseline, were recruited. Sex hormone binding globulin (SHBG), total testosterone (TT), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured. A harmonized definition and recommended thresholds for the Chinese population were used to determine metabolic syndrome.ResultsDuring 3.2 years of follow-up, 20.7% of subjects had developed MetS. Compared with the non-MetS group, subjects in the new-onset MetS group had significantly lower SHBG (43.5 nmol/L [28.8, 74.9] vs 53.7nmol/L [33.8, 115.0], P=0.0018), TT (18.1nmol/L [13.6–21.7] vs 19.5nmol/L[15.0–23.6], P=0.0204), and LH (5.13mIU/L [3.63–7.29] vs 5.87mIU/L [4.05–8.36]) at baseline. The incidence of MetS was decreased according to elevated SHBG quartiles (Q1:26.9%, Q2:22.7%, Q3:21.1%, Q4:12.1%, P for trend =0.0035), TT (Q1: 25.2%, Q2:23.7%, Q3: 17.3%, Q4: 16.7%, P for trend=0.0425), and LH (Q1:25.0%, Q2:21.8%, Q3: 21.8%, Q4: 14.3%, P for trend=0.0411). Compared with those in quartile 4, the OR[CI] of incident MetS for participants in Quartile 1 was 2.33[1.13–4.79] after multiple adjustments. But associations between incident MetS and different quartiles of LH, TT, and FSH were not observed after multiple adjustments. In the subgroup analyses, the significant association between SHBG level and Mets was detected in subjects over 60 years or older, with normal BMI, without insulin resistance, and with eGFR ≥90 mL/min per 1.73m2.ConclusionCompared with TT, LH, and FSH, a lower level of SHBG is significantly related to the incidence of MetS among middle-aged and elderly males in China.
Triglyceride-glucose index as a potential predictor of major adverse cardiovascular and cerebrovascular events in patients with coronary heart disease complicated with depression
Authors: Zhao Weizhe , Wang Junqing , Chen Dong , Ding Wanli , Hou Jiqiu , Gui YiWei , Liu Yunlin , Li Ruiyi , Liu Xiang , Sun Zhiqi , Zhao Haibin 
Published: June 2024

BackgroundTriglyceride-glucose (TyG) index is a surrogate marker of insulin resistance and metabolic abnormalities, which is closely related to the prognosis of a variety of diseases. Patients with both CHD and depression have a higher risk of major adverse cardiovascular and cerebrovascular events (MACCE) and worse outcome. TyG index may be able to predict the adverse prognosis of this special population.MethodsThe retrospective cohort study involved 596 patients with both CHD and depression between June 2013 and December 2023. The primary outcome endpoint was the occurrence of MACCE, including all-cause death, stroke, MI and emergent coronary revascularization. The receiver operating characteristic (ROC) curve, Cox regression analysis, Kaplan-Meier survival analysis, and restricted cubic spline (RCS) analysis were used to assess the correlation between TyG index and MACCE risk of in patients with CHD complicated with depression.ResultsWith a median follow-up of 31 (15–62) months, MACCE occurred in 281(47.15%) patients. The area under the ROC curve of TyG index predicting the risk of MACCE was 0.765(0.726–0.804) (P&lt;0.01). Patients in the high TyG index group(69.73%) had a significantly higher risk of developing MACCE than those in the low TyG index group(23.63%) (P&lt;0.01). The multifactorial RCS model showed a nonlinear correlation (nonlinear P&lt;0.01, overall P&lt;0.01), with a critical value of 8.80 for the TyG index to predict the occurrence of MACCE. The TyG index was able to further improve the predictive accuracy of MACCE.ConclusionsTyG index is a potential predictor of the risk of MACCE in patients with CHD complicated with depression.
Serum uric acid as a predictor of mortality in patients with stroke: results from National Health and Nutrition Examination Survey 2007–2016
Authors: Tong Xinyu , Lyu Chuxin , Guo Minjie , Gu Jianxiong , Zhao Yichun 
Published: June 2024

ObjectiveThis research endeavors to explore the relationship between serum uric acid (SUA) concentration and all-cause mortality in stroke patients.MethodsWe undertook a cross-sectional analysis utilizing data derived from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2016. The concentrations of SUA served as the independent variable, while the dependent variable was defined as all-cause mortality in stroke patients. The quartile method was utilized to classify uric acid levels into four distinct categories. Subsequently, three models were developed, and Cox proportional hazards regression was used to assess the effect of varying uric acid concentrations on the risk of all-cause mortality among stroke patients.ResultsThe study included a total of 10,805 participants, of whom 395 were stroke patients. Among all populations, the group with elevated levels of uric acid (Q4) exhibited a significant association with the overall mortality risk among stroke patients in all three models (model 1 p &lt; 0.001, model 2 p &lt; 0.001, model 3 p &lt; 0.001). In the male population, there was no significant correlation observed between uric acid levels and the overall mortality risk among stroke patients in model 3 (Q2 p = 0.8, Q3 p = 0.2, Q4 p = 0.2). However, within the female population, individuals with high uric acid levels (Q4) demonstrated a noteworthy association with the overall mortality risk among stroke patients across all three models (model 1 p &lt; 0.001, model 2 p &lt; 0.001, model 3 p &lt; 0.001).ConclusionThis cross-sectional investigation reveals a significant correlation between SUA levels and all-cause mortality in stroke patients, with a noticeable trend observed among females. Consequently, SUA may serve as a promising biomarker for assessing the prognosis of individuals affected by stroke.
Oculomotor atypicalities in motor neurone disease: a systematic review
Authors: Readman Megan Rose , Polden Megan , Gibbs Melissa C. , Donohue Aisling , Chhetri Suresh K. , Crawford Trevor J. 
Published: June 2024

IntroductionCognitive dysfunction is commonplace in Motor Neurone Disease (MND). However, due to the prominent motor symptoms in MND, assessing patients’ cognitive function through traditional cognitive assessments, which oftentimes require motoric responses, may become increasingly challenging as the disease progresses. Oculomotor pathways are apparently resistant to pathological degeneration in MND. As such, abnormalities in oculomotor functions, largely driven by cognitive processes such as saccades and smooth pursuit eye movement, may be reflective of frontotemporal cognitive deficits in MND. Thus, saccadic and smooth pursuit eye movements may prove to be ideal mechanistic markers of cognitive function in MND.MethodsTo ascertain the utility of saccadic and smooth pursuit eye movements as markers of cognitive function in MND, this review summarizes the literature concerning saccadic and smooth pursuit eye movement task performance in people with MND.Results and discussionOf the 22 studies identified, noticeable patterns suggest that people with MND can be differentiated from controls based on antisaccade and smooth pursuit task performance, and thus the antisaccade task and smooth pursuit task may be potential candidates for markers of cognition in MND. However, further studies which ascertain the concordance between eye tracking measures and traditional measures of cognition are required before this assumption is extrapolated, and clinical recommendations are made.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=376620, identifier CRD42023376620.
Metallomic analysis of brain tissues distinguishes between cases of dementia with Lewy bodies, Alzheimer’s disease, and Parkinson’s disease dementia
Authors: Scholefield Melissa , Church Stephanie J. , Xu Jingshu , Cooper Garth J. S. 
Published: June 2024

BackgroundDementia with Lewy bodies (DLB) can be difficult to distinguish from Alzheimer’s disease (AD) and Parkinson’s disease dementia (PDD) at different stages of its progression due to some overlaps in the clinical and neuropathological presentation of these conditions compared with DLB. Metallomic changes have already been observed in the AD and PDD brain—including widespread decreases in Cu levels and more localised alterations in Na, K, Mn, Fe, Zn, and Se. This study aimed to determine whether these metallomic changes appear in the DLB brain, and how the metallomic profile of the DLB brain appears in comparison to the AD and PDD brain.MethodsBrain tissues from ten regions of 20 DLB cases and 19 controls were obtained. The concentrations of Na, Mg, K, Ca, Zn, Fe, Mn, Cu, and Se were determined using inductively coupled plasma-mass spectrometry (ICP-MS). Case–control differences were evaluated using Mann–Whitney U tests. Results were compared with those previously obtained from AD and PDD brain tissue, and principal component analysis (PCA) plots were created to determine whether cerebral metallomic profiles could distinguish DLB from AD or PDD metallomic profiles.ResultsNa was increased and Cu decreased in four and five DLB brain regions, respectively. More localised alterations in Mn, Ca, Fe, and Se were also identified. Despite similarities in Cu changes between all three diseases, PCA plots showed that DLB cases could be readily distinguished from AD cases using data from the middle temporal gyrus, primary visual cortex, and cingulate gyrus, whereas DLB and PDD cases could be clearly separated using data from the primary visual cortex alone.ConclusionDespite shared alterations in Cu levels, the post-mortem DLB brain shows very few other similarities with the metallomic profile of the AD or PDD brain. These findings suggest that while Cu deficiencies appear common to all three conditions, metal alterations otherwise differ between DLB and PDD/AD. These findings can contribute to our understanding of the underlying pathogenesis of these three diseases; if these changes can be observed in the living human brain, they may also contribute to the differential diagnosis of DLB from AD and/or PDD.
Elucidating prognosis in cervical squamous cell carcinoma and endocervical adenocarcinoma: a novel anoikis-related gene signature model
Authors: Wang Mingwei- , Ying Qiaohui- , Ding Ru , Xing Yuncan- , Wang Jue , Pan Yiming- , Pan Bo , Xiang Guifen- , Liu Zhong 
Published: June 2024

BackgroundCervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are among the most prevalent gynecologic malignancies globally. The prognosis is abysmal once cervical cancer progresses to lymphatic metastasis. Anoikis, a specialized form of apoptosis induced by loss of cell adhesion to the extracellular matrix, plays a critical role. The prediction model based on anoikis-related genes (ARGs) expression and clinical data could greatly aid clinical decision-making. However, the relationship between ARGs and CESC remains unclear.MethodsARGs curated from the GeneCards and Harmonizome portals were instrumental in delineating CESC subtypes and in developing a prognostic framework for patients afflicted with this condition. We further delved into the intricacies of the immune microenvironment and pathway enrichment across the identified subtypes. Finally, our efforts culminated in the creation of an innovative nomogram that integrates ARGs. The utility of this prognostic tool was underscored by Decision Curve Analysis (DCA), which illuminate its prospective benefits in guiding clinical interventions.ResultsIn our study, We discerned a set of 17 survival-pertinent, anoikis-related differentially expressed genes (DEGs) in CESC, from which nine were meticulously selected for the construction of prognostic models. The derived prognostic risk score was subsequently validated as an autonomous prognostic determinant. Through comprehensive functional analyses, we observed distinct immune profiles and drug response patterns among divergent prognostic stratifications. Further, we integrated the risk scores with the clinicopathological characteristics of CESC to develop a robust nomogram. DCA corroborated the utility of our model, demonstrating its potential to enhance patient outcomes through tailored clinical treatment strategies.ConclusionThe predictive signature, encompassing nine pivotal genes, alongside the meticulously constructed nomogram developed in this research, furnishes clinicians with a sophisticated tool for tailoring treatment strategies to individual patients diagnosed with CESC.