bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumer Engagement in Social Media: A Systematic Literature Review of Surveys and Experiments
Authors: Salam Monalisa 
Published: August 2024

<p>Over the last decade, social media has become a ubiquitous platform for brands and influencers to bolster the reach and impact of their content, aided by customer interactions such as likes, shares, and comments. In recent years, a growing number of academic research from various disciplines examined social media engagement (SM-Engagement) primarily based on secondary data analysis by scrapping data from different social media platforms. Although this kind of research is very useful for observing the patterns in the real world, it fails to unpack the drivers of SM-Engagement. Following the PRISMA protocol, this systematic literature review aims to synthesize and combine the experimental and survey research to identify the variables and methods explored in SM-Engagement and the future research directions. By analyzing 58 academic articles consisting of 46 experiments and 40 surveys, the current review proposes a taxonomy of antecedents, mechanisms, and consequences. This review ends up with the assertion that SM-Engagement is an umbrella term encompassing a whole family of cognitive, affective, and behavioral responses representing how the audiences interact over social media. </p>
Faktor-Faktor yang Berhubungan dengan Kinerja Tenaga Kefarmasian di RSU Haji Medan
Authors: Agoes Akni Sakinah , Nasution Siti Khadijah , Zulfendri Zulfendri 
Published: August 2024

ABSTRACT Empowering pharmaceutical installations is crucial, starting with educating the hospital community about the role and purpose of pharmaceutical personnel in clinical practice. The hospital has five revenue centers, with pharmaceutical installations being the main source of revenue due to the high utilization of pharmaceutical supplies. To analyze factors related to the performance of pharmaceutical personnel in pharmaceutical services at RSU Haji Medan. This type of research is quantitative research with the research design used is a cross sectional approach. The sampling technique in this study is total sampling. The reason for using total sampling is that the population is less than 50 people, so the entire population is used as a research sample to minimize the bias that occurs. The sample in this study was 30 people. Based on the results of the study, pharmaceutical personnel obtained satisfactory compensation perceptions as many as 23 people (76.7%), good feedback as many as 23 people (86.7%), good working conditions there were 23 people (76.7%), good motivation as many as 3 people and pharmaceutical personnel who performed well as 27 people (90.0%). Perception of Compensation and Motivation is not related to the performance of pharmaceutical personnel at RSU Haji Medan. However, there is a statistically significant relationship between feedback and working conditions with the performance of pharmacy staff at RSU Haji Medan Keywords: Performance, Pharmaceutical Personnel, Hospitals ABSTRAK Pemberdayaan instalasi farmasi sangatlah penting, dimulai dengan mendidik komunitas rumah sakit tentang peran dan tujuan tenaga kefarmasian dalam praktik klinis. Rumah sakit ini memiliki lima pusat pendapatan, dengan instalasi farmasi menjadi sumber pendapatan utama karena tingginya pemanfaatan perbekalan farmasi. Untuk menganalisis faktor-faktor yang berhubungan dengan kinerja tenaga kefarmasian pada pelayanan kefarmasian di RSU Haji Medan. Jenis penelitian ini yaitu penelitian kuantitatif dengan desain penelitian yang digunakan adalah pendekatan cross sectional. Teknik pengambilan sampel dalam penelitian ini adalah dengan total sampling. Alasan digunakan total sampling adalah jumlah populasi kurang dari 50 orang maka keseluruhan populasi dijadikan sampel penelitian untuk memperkecil bias yang terjadi. Sampel dalam penelitian ini sebanyak 30 orang. Berdasarkan hasil penelitian diperoleh tenaga kefarmasian yang persepsi kompensasi memuaskan sebanyak 23 orang (76,7%), umpan balik yang baik sebanyak 23 orang (86,7%), kondisi kerja baik terdapat 23 orang (76,7%), motivasi baik sebanyak 3 orang dan tenaga kefarmasian yang kinerja baik sebanyak 27 orang (90,0%). Persepsi Kompensasi dan Motivasi tidak berhubungan dengan kinerja tenaga kefarmasian di RSU Haji Medan. Namun, ada hubungan yang signifikan secara statistik antara umpan balik dan kondisi kerja dengan kinerja staf farmasi di RSU Haji Medan. Kata Kunci: Kinerja, Tenaga Kefarmasian, Rumah Sakit.
Deciphering the molecular mechanisms underlying anti-pathogenic potential of a polyherbal formulation Enteropan® against multidrug-resistant Pseudomonas aeruginosa
Authors: Parmar Sweety , Gajera Gemini , Thakkar Nidhi , Palep Hanmanthrao S. , Kothari Vijay 
Published: August 2024

Objective: Anti-pathogenic potential of a polyherbal formulation Enteropan® was investigated against a multidrug-resistant strain of the bacterium Pseudomonas aeruginosa.
Methods: Growth, pigment production, antibiotic susceptibility, etc., were assessed through appropriate in vitro assays. Virulence of the test pathogen was assessed employing the nematode worm Caenorhabditis elegans as a model host. Molecular mechanisms underlining the anti-pathogenic activity of the test formulation were elucidated through whole transcriptome analysis of the extract-exposed bacterial culture.
Results: Enteropan-pre-exposed P. aeruginosa displayed reduced (~70%↓) virulence towards the model host C. elegans. Enteropan affected various traits like biofilm formation, protein synthesis and secretion, quorum-modulated pigment production, antibiotic susceptibility, nitrogen metabolism, etc., in this pathogen. P. aeruginosa could not develop complete resistance to the virulence-attenuating activity of Enteropan even after repeated exposure to this polyherbal formulation. Whole transcriptome analysis showed 17% of P. aeruginosa genome to get differentially expressed under influence of Enteropan. Major mechanisms through which Enteropan exerted its anti-virulence activity were found to be generation of nitrosative stress, oxidative stress, envelop stress, quorum modulation, disturbance of protein homeostasis and metal homeostasis. Network analysis of the differently expressed genes resulted in identification of 10 proteins with high network centrality as potential targets from among the downregulated genes. Differential expression of genes coding for five (rpoA, tig, rpsB, rpsL, and rpsJ) of these targets was validated through real-time polymerase chain reaction too, and they can further be pursued as potential targets by various drug discovery programmes.
MEKANISME PERTAHANAN EGO TOKOH UTAMA DALAM NOVEL YANG SULIT DIMENGERTI ADALAH PEREMPUAN KARYA FITRAWAN UMAR
Authors: Aprianti Wa Ode Annisa , Burhan Faika 
Published: August 2024

Novel Yang Sulit Dimengerti Adalah Perempuan menghadirkan tokoh utama yang mengalami kecemasan. Menurut psikoanalisis Sigmund Freud, sikap Renja menunjukkan mekanisme pertahanan ego. Penelitian ini bertujuan untuk mendeskripsikan mekanisme pertahanan ego tokoh utama dalam novel Yang Sulit Dimengerti Adalah Perempuan karya Fitrawan Umar. Penelitian ini menggunakan teori Mekanisme Pertahanan Ego dari Sigmund Freud. Penelitian ini merupakan studi pustaka yang menggunakan metode penelitan deskriptif kualitatif. Hasil penelitian menunjukkan bahwa tokoh utama melakukan mekanisme pertahanan ego. Renja sebagai tokoh utama kerap kali merasa cemburu, kesal bahkan marah kepada Adel yang merupakan perempuan yang disukainya karena menceritakan lelaki lain yang disukainya, sehingga ia melakukan mekanisme pertahanan ego untuk meminimalisir kecemasan yang dirasakannya. Mekanisme pertahanan ego yang dilakukan oleh Renja yaitu represi, reaksi formasi, agresi, rasionalisasi, fantasy, sublimasi, regresi, displacement, proyeksi.
Kata kunci: Psikologi Sastra, Psikoanalisis, Freud.
Hypoxia-induced epigenetic regulation of breast cancer progression and the tumour microenvironment
Authors: Capatina Alina L. , Malcolm Jodie R. , Stenning Jack , Moore Rachael L. , Bridge Katherine S. , Brackenbury William J. , Holding Andrew N. 
Published: August 2024

Graphical AbstractHypoxia-mediated epigenetic regulation of breast cancer progression.
Enhancing photoelectrochemical performance and stability of Ti-doped hematite photoanode via pentanuclear Co-based MOF modification
Authors: Dong Guofa , Xie Fengyan , Kou Fangxia , Chen Tingting , Xiao Caihong , Du Shaowu , Liang Jiaqi , Lou Chenfang , Zhuang Jiandong 
Published: August 2024

Modifying photoanodes with metal-organic frameworks (MOFs) as oxygen evolution reaction (OER) cocatalysts has emerged as a promising approach to enhance the efficiency of photoelectrochemical (PEC) water oxidation. However, designing OER-active MOFs with both high photo- and electrochemical stability remains a challenge, limiting the advancement of this research. Herein, we present a facile method to fabricate a MOF-modified photoanode by directly loading a pentanuclear Co-based MOF (Co-MOF) onto the surface of a Ti-doped hematite photoanode (Ti:Fe2O3). The resulting Co-MOF/Ti:Fe2O3 modified photoanode exhibits an enhanced photocurrent density of 1.80 mA∙cm−2 at 1.23 V, surpassing those of the Ti:Fe2O3 (1.53 mA∙cm−2) and bare Fe2O3 (0.59 mA∙cm−2) counterparts. Additionally, significant enhancements in charge injection and separation efficiencies, applied bias photon-to-current efficiency (ABPE), incident photon to current conversion efficiency (IPCE), and donor density (Nd) were observed. Notably, a minimal photocurrent decay of only 5% over 10 h demonstrates the extraordinary stability of the Co-MOF/Ti:Fe2O3 photoanode. This work highlights the efficacy of polynuclear Co-based MOFs as OER cocatalysts in designing efficient and stable photoanodes for PEC water splitting applications.
Health condition and socioeconomic status mediate the causal effect of reproductive traits on nonalcoholic fatty liver disease: evidence from Mendelian randomization study
Authors: Wang Qiaoyun , Wang Liming , Hao Rui , Zhang Lijiu , Wang Wenyan , Xia Lingling 
Published: August 2024

BackgroundObservational data posits a correlation between reproductive traits and nonalcoholic fatty liver disease (NAFLD), but their causal inference is still unclear. This investigation seeks to elucidate the causal influence of reproductive traits on NAFLD and determine the intervening role of health condition and socioeconomic status in these connections.MethodsUtilizing a Mendelian Randomization (MR) approach, this research leveraged a comprehensive dataset from the Genome-wide Association Study (GWAS) database. The study incorporated body mass index, major depression, educational level, household income and Townsend deprivation index as intermediary variables. Initially, a bidirectional two-sample MR study was conducted to explore the genetic associations between reproductive traits and NAFLD. Then, two-step MR analyses were implemented to quantify the extent of mediation by these indicators. The weighted inverse variance method was the primary analytical approach, complemented by several sensitivity analyses to affirm the robustness of the MR assumptions. Finally, these findings were validated in the FinnGen research.ResultsThe bidirectional MR analysis indicated that earlier reproductive traits (age at menarche, age at first sexual intercourse, and age at first birth) were associated with an elevated risk of NAFLD, absent any evidence of the reverse relationship. Body mass index accounted for 35.64% of the association between premature menarche and NAFLD. Additionally, body mass index, major depression, educational level and household income mediated 41.65%, 14.35%, 37.88%, and 18.59% of the connection between early sexual intercourse and NAFLD, respectively. Similarly, these same variables elucidated 36.36%, 15.58%, 41.56%, and 22.73% of the correlation between younger age at first birth and NAFLD.ConclusionOur study elucidated the causal relationships between reproductive traits and NAFLD. Potential underlying mechanisms may involve factors such as body mass index, major depression, educational attainment and household income.
Genotype and clinical phenotype characteristics of MAX germline mutation–associated pheochromocytoma/paraganglioma syndrome
Authors: Lian Bijun , Lu Jun , Fang Xudong , Zhang Yiming , Wang Wei , He Yi , Yu Hongyuan , Li Feiping , Wang Junwei , Chen Weiying , Qi Xiaoping 
Published: August 2024

ObjectiveThe aim of this study was to investigate the genotypic and clinical phenotypic characteristics of MAX germline mutation–associated pheochromocytoma (PCC) and paraganglioma (PGL).MethodsWe retrospectively analyzed the family investigation data and clinical genetic characteristics of six individuals from three independent families with PCC carrying MAX germline mutations from December 2005 to March 2024. A literature review was then conducted of the six carriers and another 103 carriers from the other 84 families with MAX germline mutations reported previously.ResultsThere were 109 patients in 87 families with all five exons and 53 types of MAX germline mutations. p.R33* (c.97C&gt;T; 21.1%), p.R75* (c.223C&gt;T; 13.8%), and p.A67D (c.200C&gt;A; 7.3%), which accounted for 42.2% of mutations detected, were the most common mutations. Moreover, 101 (92.7%) patients developed PCCs, including 59 bilateral PCCs and 42 unilateral PCCs, and 19 (18.8%) patients showed metastasis. The mean age at diagnosis was 32.8 ± 12.6 (13-80) years. The male-to-female ratio was 1.3:1. In 11 (10.9%) patients, the PCC was accompanied by chest or abdominal PGL, and one other patient had sole head and neck PGL. Nine (8.3%) patients also had functional pituitary adenomas, 11 (10.9%) developed other neuroendocrine tumors (NETs), and 7 (6.4%) presented with concomitant non-NET. Meanwhile, MAX-p.Q82Tfs*89 and p.E158A mutations are reported for the first time in this study.ConclusionMAX germline mutations may cause new types of multiple endocrine neoplasia. A comprehensive baseline assessment of neural crest cell–derived diseases is recommended for all individuals with MAX germline mutations. The risk of bilateral and metastatic PCCs should also be considered.
Silicon effects on soil phosphorus availability: results obtained depend on the method used
Authors: Uhuegbue Peter Onyisi , Stein Mathias , Kalbitz Karsten , Schaller Jörg 
Published: August 2024

Phosphorus limitation occurs in many soils as a significant amount of soil P is retained in forms inaccessible to plants, such as bound to iron (Fe) minerals. Prior studies have shown that silicon (Si) can mobilize P from the binding sites of such minerals. Several P extraction methods have been developed to account for different P pools. Nevertheless, each of those methods uses different extractants and mechanisms to extract different P pools in soils. However, there is no study comparing different P extraction methods in the presence of Si fertilization. We tested the effect of Si on P mobility and determined the efficiency of water, Calcium acetate lactate (CAL), Mehlich-III, and Bray and Kurtz extraction methods for extracting P in the presence of amorphous silica (ASi) fertilization using two soils of contrasting characteristics. Significantly higher amounts of P were found at 3% ASi treatments (10 and 21 mg P kg-1) compared to the control (4 and 10 mg P kg-1) in the water extract in the high and low-yield soil, respectively just after 6 hours of extraction and increased with time. This may be explained by Si directly competing with P for sorption to Fe minerals. Using CAL extraction, Si addition showed no effect on P extractability. In contrast, the Mehlich-III and Bray extraction methods showed decreasing P extractability, especially at 3% ASi treatment (95 and 60 mg P kg-1) compared to the control (115 and 80 mg P kg-1) for the high-yield soil. The decreasing P contents in the presence of Si found in the Mehlich-III and Bray extracts may be attributed to the decrease in extraction effectiveness of the extractants to extract P while extracting Si and Fe. Our results showed that the Mehlich-III and Bray extraction methods may not be suitable for the determination of P availability in the presence of ASi fertilization since both extractants also extract Si and this may limit the completeness of P extraction. Therefore, in the presence of Si fertilizer, the water extraction method may be suitable to determine P availability and mobilization due to ASi.
Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model
Authors: Liu Na , Sonawane Mitali , Sommerfeld Oliver , Svensson Carl-Magnus , Figge Marc Thilo , Bauer Reinhard , Bischoff Sabine Juliane , Bauer Michael , Osuchowski Marcin Filip , Press Adrian Tibor 
Published: August 2024

BackgroundLimited availability and side effects of opioids have led to an increased use of non-opioid analgesia in animal disease models. However, by affecting the immune-inflammatory reactions, analgesia may disrupt the resolution of the host inflammation and modulate the survival in septic animals. This study used a clinically relevant sepsis mouse model of peritoneal contamination and infection (PCI) to investigate the antinociceptive and anti-inflammatory properties of two non-opioid analgesics.MethodsAdult C57BL/6J mice were intraperitoneally injected with a human feces suspension and received either no analgesics (Non-A), Meloxicam, or Metamizole orally. The mice were monitored for pain and illness. Mortality was assessed at 7 days post-PCI. A separate group of mice was sacrificed 24 hours after infection. Blood, peritoneal lavage fluid (PLF), liver, and spleen were harvested for pathogen load quantification via qPCR, macrophage phenotyping, neutrophil infiltration/activation, and systemic/tissue cytokine release by flow cytometry.ResultsMeloxicam but not Metamizole reduced the mortality of septic mice by 31% on day 7 compared to the Non-A group. Both analgesics effectively alleviated pain but did not affect illness severity, body weight, and temperature. Meloxicam quadrupled the bacterial burden in the blood and PLF. In high IL-6 responders, Meloxicam treatment was associated with reduced circulating IL-10 and IL-1β compared to the Non-A septic group. In low IL-6 responders, Meloxicam increased circulating MCP-1 levels and decreased PGE2 levels compared to Non-A septic mice. Notably, Meloxicam reduced spleen neutrophil infiltration by 20% compared to two other sepsis groups.ConclusionMetamizole and Meloxicam effectively relieved pain and increased the animals’ basal activity in the PCI sepsis model. Meloxicam prolonged survival yet triggered maladaptive responses due to its immunosuppressive features that decreased tissue bacterial clearance during sepsis. In contrast, Metamizole constitutes a safe and effective non-opioid alternative for analgesic control in the non-surgical PCI sepsis model.
Deficiency and dysfunctional roles of natural killer T cells in patients with ARDS
Authors: Park Ki-Jeong , Kim Tae-Ok , Cho Young-Nan , Jin Hye-Mi , Jo Young-Goun , Shin Hong-Joon , Kho Bo Gun , Kee Seung-Jung , Park Yong-Wook 
Published: August 2024

ObjectiveAcute respiratory distress syndrome (ARDS) presents a global health challenge, characterized by significant morbidity and mortality. However, the role of natural killer T (NKT) cells in human ARDS remains poorly understood. Therefore, this study explored the numerical and functional status of NKT cells in patients with ARDS, examining their clinical relevance and interactions with macrophages and fibroblasts during various stages of the syndrome.MethodsPeripheral blood from 40 ARDS patients and 30 healthy controls was analyzed, with paired samples of peripheral blood and bronchoalveolar lavage fluid (BALF) from seven ARDS patients. We measured levels of NKT cells, cytokines, CD69, programmed death-1 (PD-1), and annexin-V using flow cytometry, and extracellular matrix (ECM) protein expression using real-time PCR.ResultsARDS patients exhibited decreased circulating NKT cells with elevated CD69 expression and enhanced IL-17 production. The reduction in NKT cells correlated with PaO2/FiO2 ratio, albumin, and C-reactive protein levels. Proliferative responses to α-galactosylceramide (α-GalCer) were impaired, and co-culturing NKT cells with monocytes or T cells from ARDS patients resulted in a reduced α-GalCer response. Increased and activated NKT cells in BALF induced proinflammatory cytokine release by macrophages and ECM protein expression in fibroblasts.ConclusionARDS is associated with a numerical deficiency but functional activation of circulating NKT cells, showing impaired responses to α-GalCer and altered interactions with immune cells. The increase in NKT cells within BALF suggests their role in inducing inflammation and remodeling/fibrosis, highlighting the potential of targeting NKT cells as a therapeutic approach for ARDS.
Efficacy and safety of transarterial chemoembolization plus lenvatinib combined with PD-1 inhibitors versus transarterial chemoembolization plus lenvatinib for unresectable hepatocellular carcinoma: a meta-analysis
Authors: Chen Yue , Jia Luyao , Li Yu , Cui Wenhao , Wang Jukun , Zhang Chao , Bian Chunjing , Luo Tao 
Published: August 2024

BackgroundLocoregional treatment combined with systemic therapy is expected to play a synergistic anticancer role. We conducted this systemic meta-analysis to examine the efficacy and safety of transarterial chemoembolization (TACE) plus lenvatinib with or without programmed cell death protein-1 (PD-1) inhibitors (TLP group) compared with TACE + lenvatinib (TL group) for unresectable hepatocellular carcinoma (uHCC).MethodsFrom the inception date to April 2024, the data from PubMed, EMBASE, the Cochrane Library, Ovid, Web of Science, and Clinical Trials. gov were used for meta-analysis. All clinical outcomes of interest included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs). The hazard ratio (HR) and risk ratio (RR) with 95% confidence intervals (CI) were used to measure the pooled effect.ResultsThis study included 10 retrospective cohort studies, including 1128 patients. The OS (HR=0.51; 95% CI: 0.43–0.60, P &lt; 0.05), PFS (HR=0.52; 95% CI: 0.45–0.61, P &lt; 0.05), ORR (RR = 1.58; 95% CI: 1.37–1.83; P &lt; 0.05) and DCR (RR = 1.31; 95% CI: 1.20–1.43; P &lt; 0.05) were significantly higher in TLP group than in the TL group. The incidence of AEs was acceptable. Prognostic factor analysis identified that ECOG PS (1/0), Child-Pugh class (B/A), BCLC stage (C/B) and main portal vein invasion (yes/no) were independent prognostic factors for OS. BCLC stage (C/B) and main portal vein invasion (yes/no) were independent prognostic factors for PFS.ConclusionThe TLP group had better efficacy for uHCC than that of the TL group, with acceptable safety.Systematic review registrationPROSPERO, identifier (CRD42023420093).