bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controlling false discovery rate for mediator selection in high-dimensional data
Authors: Dai Ran , Li Ruiyang , Lee Seonjoo , Liu Ying 
Published: July 2024

ABSTRACT
The need to select mediators from a high dimensional data source, such as neuroimaging data and genetic data, arises in much scientific research. In this work, we formulate a multiple-hypothesis testing framework for mediator selection from a high-dimensional candidate set, and propose a method, which extends the recent development in false discovery rate (FDR)-controlled variable selection with knockoff to select mediators with FDR control. We show that the proposed method and algorithm achieved finite sample FDR control. We present extensive simulation results to demonstrate the power and finite sample performance compared with the existing method. Lastly, we demonstrate the method for analyzing the Adolescent Brain Cognitive Development (ABCD) study, in which the proposed method selects several resting-state functional magnetic resonance imaging connectivity markers as mediators for the relationship between adverse childhood events and the crystallized composite score in the NIH toolbox.
Causal meta-analysis by integrating multiple observational studies with multivariate outcomes
Authors: Guha Subharup , Li Yi 
Published: July 2024

ABSTRACT
Integrating multiple observational studies to make unconfounded causal or descriptive comparisons of group potential outcomes in a large natural population is challenging. Moreover, retrospective cohorts, being convenience samples, are usually unrepresentative of the natural population of interest and have groups with unbalanced covariates. We propose a general covariate-balancing framework based on pseudo-populations that extends established weighting methods to the meta-analysis of multiple retrospective cohorts with multiple groups. Additionally, by maximizing the effective sample sizes of the cohorts, we propose a FLEXible, Optimized, and Realistic (FLEXOR) weighting method appropriate for integrative analyses. We develop new weighted estimators for unconfounded inferences on wide-ranging population-level features and estimands relevant to group comparisons of quantitative, categorical, or multivariate outcomes. Asymptotic properties of these estimators are examined. Through simulation studies and meta-analyses of TCGA datasets, we demonstrate the versatility and reliability of the proposed weighting strategy, especially for the FLEXOR pseudo-population.
Prevalence of extended-spectrum β-lactamase-producing Enterobacterales in edible ice in Thailand
Authors: Amornchai Premjit , Wuthiekanun Vanaporn , Langla Sayan , Wongsuvan Gumphol , Aramrueang Panatda , Day Nicholas P J , Limmathurotsakul Direk 
Published: July 2024

Abstract

Background
The presence of antimicrobial-resistant (AMR) bacteria in edible ice in tropical countries is largely unknown.

Methods
We evaluate the presence of extended-spectrum β-lactamase (ESBL)-producing Enterobacterales in 100 edible ice samples from drink carts in 20 markets in four provinces (five markets/province) in Thailand. Ten samples of commercially sold edible ice in sealed packages were tested as controls.

Results
Of 100 samples, 29 (29%) were culture positive for ESBL-producing Enterobacterales, with a median quantitative count of 2 colony-forming units (CFU)/100 mL (range, 1 to 40 CFU/100 mL). All control samples were culture negative for ESBL-producing Enterobacterales.

Conclusions
AMR bacteria is commonly found in edible ice from drink carts.
SNO-EANO-EURACAN consensus on management of pineal parenchymal tumors
Authors: Liu Anthony P Y , Li Bryan K , Vasiljevic Alexandre , Dewan Michael C , Tamrazi Benita , Ertl-Wagner Birgit , Hansford Jordan R , Pfaff Elke , Mynarek Martin , Ng Ho-Keung , Tsang Derek S , Gottardo Nicholas G , Gajjar Amar , Bouffet Eric , Dufour Christelle , Pizer Barry , Schiff David , Jenkinson Michael D , Lombardi Giuseppe , Wen Patrick Y , van den Bent Martin J , Huang Annie 
Published: July 2024

Abstract
Pineal parenchymal tumors are rare neoplasms for which evidence-based treatment recommendations are lacking. These tumors vary in biology, clinical characteristics, and prognosis, requiring treatment that ranges from surgical resection alone to intensive multimodal antineoplastic therapy. Recently, international collaborative studies have shed light on the genomic landscape of these tumors, leading to refinement in molecular-based disease classification in the 5th edition of the World Health Organization (WHO) classification of tumors of the central nervous system. In this review, we summarize the literature on diagnostic and therapeutic approaches, and suggest pragmatic recommendations for the clinical management of patients presenting with intrinsic pineal region masses including parenchymal tumors (pineocytoma, pineal parenchymal tumor of intermediate differentiation, and pineoblastoma), pineal cyst, and papillary tumors of the pineal region.
The right to privacy and the deep self
Authors: Menges Leonhard 
Published: July 2024

Abstract
This paper presents an account of the right to privacy that is inspired by classic control views on this right and recent developments in moral psychology. The core idea is that the right to privacy is the right that others not make personal information about us flow unless this flow is an expression of and does not conflict with our deep self. The nature of the deep self will be spelled out in terms of stable intrinsic desires. The paper argues that this view has advantages over alternative accounts of the right to privacy, that it is extensionally adequate in interesting test cases, that there is a good reason to think that the right to privacy, thus understood, can be justified, and that this view helps identify what kind of information is protected by the right to privacy.
Evidence further linking the intestine to cardiovascular disease
Authors: Sulaiman Dawoud , Reddy Srinivasa T. , Fogelman Alan M. 
Published: July 2024

Purpose of review
To review recent publications linking the intestine to cardiovascular disease.

Recent findings
Aromatic amino acid-derived metabolites produced by gut-bacteria were identified that increased or decreased the risk of cardiovascular events. Dietary phenylalanine was metabolized to phenylacetic acid by gut microbes, and converted into phenylacetylglutamine by the host, which increased thrombosis potential via adrenergic receptors and was associated with increased major adverse cardiovascular events. Another microbiota-associated metabolite of aromatic amino acids, indole-3-propionic acid, protected against heart failure with preserved ejection fraction. The mechanism by which dietary cholesterol is absorbed was found to involve the Nieman–Pick C1-like1 protein working together with a newly discovered protein called Aster. Levels of gut-derived bacterial lipopolysaccharide in serum that are an order of magnitude less than those seen in gram negative sepsis were shown to play a role in enhancing atherosclerosis and thrombosis.

Summary
Promising new therapeutic targets in the intestine for preventing or treating cardiovascular disease have been identified.
What Happens to Topics and Conversations When People With Aphasia Have Time to Repair Their Speaking Turns? A Systematic, Functional Investigation
Authors: Archer Brent , Leaman Marion C. , Mok Zaneta 
Published: July 2024

People with aphasia may produce speech errors or pauses during speaking turns. A communication partner may choose to guess the person’s intended meaning, or may allow the person time to repair their turns (i.e., edited turns).
The aim of this study was to understand the topic-related effects that occur when speakers without aphasia allow their partners with aphasia to complete their own repairs. We analyzed videos of 10 people with aphasia engaged in social conversations with communication partners. We identified and extracted “PWA-initiated segments” (PWA-IS). These segments begin with turns in which PWAs carry out repairs and introduce new topics (both actions occur in a single turn). PWA-ISes continue until the last turn about the topic is completed. We calculated descriptive statistics detailing the proportion of turns/words in each conversation represented by PWA-IS’s, as well as the range and mean of these proportions across conversations. This approach allowed us to understand how many of the turns in each conversation were dependent on the new topics introduced by people with aphasia when they were afforded time for self-expression during their edited utterances. On average, 35% of turns and 38% of words occurred during PWA-ISes. In general, substantial proportions of conversations we analyzed were related to topics introduced by people with aphasia during PWA-ISes. Edited turns initiate segments composed of topically-related turns, and these segments occupied large portions of the conversations we analyzed. Giving people with aphasia time to edit their own turns may thus play an important role in steering conversation toward the topics and interactional agendas that people with aphasia wish to pursue.
Building success: the impact of talent recruitment on the growth of the construction industry
Authors: Zhang Wei , Ding Ning , Xue Rui , Han Yilong , Liu Chenyu 
Published: July 2024

PurposeIn today’s digital era, talent recruitment can help address the growing shortage of skilled labor in the construction industry and promote sustainable growth. While existing research has explored the association between talent acquisition and local labor productivity or economic progress, the impact on construction growth deserves further study. This study aims to (1) explore the influence of talent recruitment on the growth of the construction industry and (2) analyze whether different regional characteristics shape the differential impact of talent acquisition on construction growth.Design/methodology/approachThis research employs a quantitative approach, focusing on 35 major cities in China. A panel data regression model is utilized to analyze annual data from 2013 to 2018, considering variables like the construction talent recruitment index, value added in construction, gross regional product per capita and others. The study also examines regional heterogeneity and conducts robustness tests to validate the findings.FindingsThe results reveal a positive and significant correlation between talent recruitment and construction industry growth. This correlation is more pronounced in economically advanced and infrastructure-rich regions. The study also finds that factors like capital investment, educational attainment and housing prices significantly contribute to industry growth. Talent recruitment not only transforms local labor market dynamics but also drives demand for construction services, promoting industry growth through economies of scale.Originality/valueThis research constructs a new measurement for talent recruitment and provides new insights into the pivotal role of talent recruitment in the sustainable growth of the construction industry. It underscores the need for construction firms to tailor talent acquisition policies to their specific circumstances and regional developmental conditions. The findings offer practical guidance for driving regional growth within the sector, emphasizing the importance of talent recruitment as a key yet previously underappreciated factor in industry development.
Decoding mindfulness for organisations by exploring the perceptions of mindfulness masters: an indigenous approach
Authors: Saini Damini 
Published: July 2024

Purpose
Researchers, academicians and practitioners are trying to make employees more mindful, as mindfulness brings a lot of excellence to work. This study aims to unwrap and decode the mindfulness procedure by identifying the crucial steps to ease the process for employees and organisations.

Design/methodology/approach
The qualitative research method assessed 20 semi-structured interviews with mindfulness experts in India and abroad. Interpretive phenomenological analysis was used to analyse the content generated by the data collection.

Findings
Though the understanding of mindfulness is univocal and standard, this investigation fills the gap of initial groundwork concerning thoughtlessness, as it remains a less observed area in earlier research in mindfulness. This research study also found organisational ways to enhance mindfulness in the system, such as ostentatious listening, detail orientation, deep discussions, one task at a time, etc.

Originality/value
The study is unique in that it explores the perceptions and views of mindfulness coaches and masters and tries to demystify the procedure of being mindful in organisations.
Unveiling the African growth puzzle: relationship between financial inclusion, debt sustainability and economic growth
Authors: Ahiase Godwin , Sari Maya , Andriana Denny , Nugraha Nugraha , Purnomo Budi Supriatono , Heryana Toni 
Published: July 2024

PurposeThis study examines the moderating role of debt sustainability on the nexus between financial and economic growth in African countries.Design/methodology/approachThis study utilised data from various sources, such as the World Bank and International Monetary Fund databases, specifically the World Development Indicators and Financial Access Survey. The data covered the period from 2004 to 2021 and focused on 53 African countries to examine the moderating effect of debt sustainability on the relationship between financial inclusion and economic growth using a two-step generalised method of moments system with forward orthogonal deviations.FindingsThe study findings indicate a direct link between financial inclusion and economic growth in African nations. In particular, the availability and utilisation of mobile money services are significant factors in promoting financial inclusion. Our study also highlights that excessive debt can impede economic growth by limiting the capacity of financial institutions to offer loans and other vital financial services.Practical implicationsPolicymakers in Africa should promote economic growth by prioritising financial inclusion through mobile money and ATMs while ensuring sustainable debt levels.Originality/valueThis study adds to the ongoing discussion on the relationship between FI and economic growth in African countries. It explores how debt sustainability affects this relationship, and emphasises the importance of finding a balance between financial inclusion and debt management for long-term economic growth and development.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-01-2024-0062
Digital transformation in Vietnamese higher education: an epistemic network analysis of policy documents
Authors: Nguyen Huong Lan , Dang Belle , Hong Yvonne , Nguyen Andy 
Published: July 2024

PurposeThis study aimed to utilize Epistemic Network Analysis (ENA) for a thorough evaluation of policy documents concerning the digital transformation in Vietnam's higher education sector.Design/methodology/approachAdopting a quantitative ethnography approach, this research employed ENA to analyse a curated collection of 21 documents that specifically addressed higher education (HE) and digital transformation within Vietnam. The study also incorporated qualitative content analysis, utilizing the constant comparison method as outlined by Onwuegbuzie et al. (2009), for data coding. ENA facilitated the examination of connections among various policy aspects.FindingsThe study revealed a consistent overarching theme in Vietnam's digital transformation policies during and post-pandemic, focusing on key areas such as ADMINISTRATION, VISION, QUALITY, and INFRASTRUCTURE. However, a temporal shift in emphasis was observed: during the pandemic, policies were more focused on ADMINISTRATION and INFRASTRUCTURE, while post-pandemic, there was an increased emphasis on COLLAB, VISION, and TEACH_LEARN.Originality/valueThis research represents one of the initial efforts to showcase the utility and significance of ENA in analysing policy documents. It underscores ENA's potential in elucidating the complex interplay of policy elements in the context of digital transformation in higher education, particularly within a developing country setting.
Irisin preserves mitochondrial integrity and function in tubular epithelial cells after ischemia–reperfusion‐induced acute kidney injury
Authors: Cui Yu , Yu Lu , Cong Wenqi , Jiang Shan , Qiu Xingyu , Wei Chunchun , Zheng Gui , Mao Jianhua , Liu Ruisheng , Patzak Andreas , Persson Pontus B. , Chen Jianghua , Zhao Liang , Lai En Yin 
Published: July 2024

AbstractAimsA myokine secreted by skeletal muscles during exercise called irisin mitigates ischemia–reperfusion (I/R) injury in epithelial cells of various organs by limiting damage to mitochondria. We test whether irisin may preserve the mitochondrial integrity and function in renal tubular epithelial cells and protect against ischemia–reperfusion‐induced acute kidney injury (AKI).MethodsWe correlated serum irisin levels with serum creatinine and BUN levels from both AKI patients and healthy individuals. In mice with irisin administration, various renal injury markers such as serum creatinine, BUN, kidney injury molecule‐1 (Kim‐1), and neutrophil gelatinase‐associated lipocalin (NGAL), and renal histopathology were assessed after I/R. To identify the potential mechanisms of the protective of irisin's protective effect, we perfused proximal tubules under confocal microscopy and analyzed kidney tissues by qPCR, western blot, and immunohistochemistry.ResultsSerum irisin correlated inversely with serum creatinine and BUN levels were significantly lower in AKI patients than in healthy subjects. Administering irisin to mice after I/R decreased biomarker levels for AKI including serum creatinine, BUN, Kim‐1, NAGL and lessened histological changes. In kidney tissues of mice, irisin upregulated the mitochondrial autophagy marker protein microtubule‐associated protein 1 light chain 3 (LC3), the mitochondrial autophagy pathway‐related proteins PTEN‐induced putative kinase 1 (PINK1) and Parkinson's disease 2 parkin (PARK2) and downregulated the reactive substrate protein sequestosome 1 (P62) and mitochondrial membrane proteins translocase of outer mitochondrial membrane 20 (TOM20) and translocase of inner mitochondrial membrane 23 (TIM23).ConclusionIrisin protects against renal I/R injury, which may involve the preservation of mitochondrial integrity and function.
Start‐up acquisitions, strategic R&D, and the entrant's and incumbent's direction of innovation
Authors: Dijk Esmée S. R. , Moraga‐González José L. , Motchenkova Evgenia 
Published: July 2024

AbstractAn entrant and an incumbent allocate their research funds across a rival and a non‐rival market. The prospect of an acquisition distorts both players' incentives to allocate funding. Allowing for acquisitions may improve both players' innovation direction and consumer surplus. Under conditions, the incumbent, anticipating monopolization rents in the rival market, moves R&D towards that market. This “incumbency for buyout” effect lowers the rents the entrant obtains from the contestable market, which gives it incentives to move R&D resources away from the rival market. Such strategic interaction in the R&D market has implications for the assessment of start‐up acquisitions.
Updated criteria for the approval of subsequent pregnancy after cesarean section with a transverse uterine fundal incision based on 17 years of experience
Authors: Shibata Takashi , Nishijima Koji , Nakago Satoshi , Kotsuji Fumikazu 
Published: July 2024

AbstractIn the case of placenta previa‐accreta when the placenta covers the entire anterior uterine wall, it is difficult to avoid transecting the placenta by traditional low‐transverse cesarean section (CS), resulting in catastrophic hemorrhage and fetal anemia. To prevent this critical risk, we developed the CS with transverse uterine fundal incision (TUFI) and this technique has been widely used as a beneficial surgical method in clinical practice owing to its safety advantages for the mother and neonate since our first report. However, the risk of uterine rupture during a subsequent pregnancy remains unclear. Based on our 17 years of experience, patients who require TUFI do not need to avoid this beneficial operative method simply because of their desire to conceive again, as long as certain conditions can be met. To approve a post‐TUFI pregnancy, an appropriate suture method, delay in conception for at least 12 months with evaluation of the TUFI scar, and cautious postoperative management are at a minimum essential. In this article, we showed our recommendation for operative procedure and discuss the current status of the management of post‐TUFI pregnancies based on the evaluation of the TUFI wound scar and experience with postoperative pregnancies.
A cystathionine beta‐synthase domain containing protein, OsCBSCBS4, interacts with OsSnRK1A and OsPKG and functions in abiotic stress tolerance in rice
Authors: Tomar Surabhi , Subba Ashish , Chatterjee Yajnaseni , Singhal Nitin Kumar , Pareek Ashwani , Singla‐Pareek Sneh Lata 
Published: July 2024

AbstractThe Cystathionine‐β‐Synthase (CBS) domain‐containing proteins (CDCPs) constitute a functionally diverse protein superfamily, sharing an evolutionary conserved CBS domain either in pair or quad. Rice genome (Oryza sativa subsp. indica) encodes 42 CDCPs; their functions remain largely unexplored. This study examines OsCBSCBS4, a quadruple CBS domain containing protein towards its role in regulating the abiotic stress tolerance in rice. Gene expression analyses revealed upregulation of OsCBSCBS4 in response to diverse abiotic stresses. Further, the cytoplasm‐localised OsCBSCBS4 showed interaction with two different kinases, a cytoplasmic localised cGMP‐dependant protein kinase (OsPKG) and the nucleo‐cytoplasmic catalytic subunit of sucrose‐nonfermentation 1‐related protein kinase 1 (OsSnRK1A). The interaction with the latter assisted in trafficking of OsCBSCBS4 to the nucleus as well. Overexpression of OsCBSCBS4 in rice resulted in enhanced tolerance to drought and salinity stress, via maintaining better physiological parameters and antioxidant activity. Additionally, OsCBSCBS4‐overexpressing rice plants exhibited reduced yield penalty under stress conditions. The in silico docking and in vitro binding analyses of OsCBSCBS4 with ATP suggest its involvement in cellular energy balance. Overall, this study provides novel insight into the unexplored functions of OsCBSCBS4 and demonstrates it as a new promising target for augmenting crop resilience.