bluuebunny/crossref_metadata_2025_split huggingface dataset:
In utero exposure to antihistamines and risk of hepatocellular carcinoma in a multigenerational cohort
Authors: Murphy Caitlin C. , Seif El Dahan Karim , Singal Amit G. , Cirillo Piera M. , Krigbaum Nickilou Y. , Cohn Barbara A. 
Published: July 2024

Background:
Growing evidence suggests that liver disease originates in early life. Antihistamines cross the placenta and are frequently prescribed to pregnant women to treat nausea and vomiting, as well as allergy and asthma symptoms. Exposure to antihistamines in utero may impact the developing liver by reprogramming or inducing epigenetic changes in fetal hepatocytes.

Methods:
We examined in utero exposure to antihistamines and the risk of HCC in the Child Health and Development Studies, a multigenerational cohort that enrolled pregnant women in the East Bay, CA, between 1959 and 1966 (n=14,507 mothers and 18,751 liveborn offspring). We reviewed mothers’ medical records to identify those prescribed antihistamines during pregnancy, and diagnoses of HCC in adult (age ≥18 y) offspring were identified by linkage with a population-based cancer registry. Cox proportional hazard models were used to estimate adjusted hazard ratios, with follow-up accrued from birth through cancer diagnosis, death, or last contact.

Results:
About 15% of offspring (n=2759 of 18,751) were exposed in utero to antihistamines. Chlorpheniramine (51.8%) and diphenhydramine (15.4%) were the 2 most commonly prescribed antihistamines. Any in utero exposure was not associated with HCC (adjusted hazard ratio: 2.76, 95% CI: 0.70, 10.89), but the association differed by timing of exposure. Offspring exposed to antihistamines in the first or second trimester had a higher risk of HCC compared to offspring not exposed (adjusted hazard ratio: 4.64, 95% CI: 1.21, 17.78). Similarly, incidence rates were 4.3 per 100,000 (95% CI: 0.9, 12.6) for offspring exposed in the first or second trimester compared to 1.0 per 100,000 (95% CI: 0.3, 2.1) for offspring not exposed.

Conclusions:
In utero exposure to antihistamines in early pregnancy may increase the risk of HCC in adulthood.
A Partner-Engaged Approach to Developing an Implementation Research Logic Model for a Traumatic Brain Injury-Intensive Evaluation and Treatment Program
Authors: Haun Jolie N. , Melillo Christine , Schneider Tali , McDaniel Justin , McMahon-Grenz Julie , Benzinger Rachel C. , Nakase-Richardson Risa , Pugh Mary Jo V. , Skop Karen M. , Friedman Yvonne , Sandoval Roberto , Sabangan Jerome , Samson Kimberly , Picon Linda M. , Kean Jacob 
Published: July 2024

Background:
A partnered evaluation project with Veterans Health Administration Physical Medicine and Rehabilitation program office uses a partner-engaged approach to characterize and evaluate the national implementation of traumatic brain injury (TBI)Intensive Evaluation and Treatment Program (IETP).

Objective:
This paper illustrates a partner-engaged approach to contextualizing the IETP within an implementation research logic model (IRLM) to inform program sustainment and spread.

Setting:
The project was conducted at five IETP sites: Tampa, Richmond, San Antonio, Palo Alto, and Minneapolis.

Participants:
Partners included national and site program leaders, clinicians, Department of Defense Referral Representatives, and researchers. Participants included program staff (n = 46) and Service Members/Veterans (n = 48).

Design:
This paper represents a component of a larger participatory-based concurrent mixed methods quality improvement project.

Main Measures:
Participant scripts and demographic surveys.

Methods:
Datasets were analyzed using rapid iterative content analysis; IETP model was iteratively revised with partner feedback. Each site had an IETP clinical team member participate. The IRLM was contextualized within the Consolidated Framework for Implementation Research (CFIR); systematic consensus building expert reviewed implementation strategies; RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance); and Implementation Outcomes Framework (IOF).

Results:
Analyses and partner feedback identified key characteristics, determinants, implementation strategies, mechanisms, and outcomes.

Conclusions:
This partner-engaged IRLM informs implementation and sustainment of a rehabilitation program for individuals with TBI. Findings will be leveraged to examine implementation, standardize core outcome measurements, and inform knowledge translation.
Normothermic regional perfusion in controlled DCD liver procurement: Outcomes of the Swedish national implementation protocol
Authors: Bluhme Emil , Gäbel Markus , Martinez de la Maza Lilia , Nilsén Vera , Hildebrand Karin , Jarsäter Jenni , Bååth Cecilia , Proos Matilda , Romano Antonio , Villard Christina , Oniscu Gabriel C. , Gustafsson Niklas , Thompson Monica , Hansson Christoffer , Löfstedt Margareta , Andersson Lindholm Jonas , Falk Lars , Bennet William , Jorns Carl 
Published: July 2024

Liver transplantation (LTX) using donors after controlled circulatory death (cDCD) is associated with poorer graft survival and increased incidence of nonanastomotic biliary strictures (NASs) compared to livers procured from brain-dead donors (DBD). The use of normothermic regional perfusion (NRP) during cDCD procurement may improve posttransplant outcomes and reduce the incidence of NAS. In Sweden, cDCD LTX was introduced through a national pilot protocol with mandatory NRP. This study aims to evaluate the outcome of cDCD LTX during the pilot period. Donor and recipient data were collected on all cDCD liver transplants during the pilot period between January 2020 to December 2022. Outcome on NAS, patient and graft survival, early allograft dysfunction, acute kidney injury, and comprehensive complication index was compared to a matched cohort of 28 patients transplanted with a DBD liver between 2018 and 2022. Eighteen patients were transplanted with a liver from a cDCD donor after using NRP. The mean functional warm ischemia time was 29 ± 6 minutes. The mean lactate reduction during NRP was 8.7 ± 2.4 mmol/L, and the end NRP perfusate alanine aminotransferase was 1.4 ± 1 µkat/L. When comparing recipients of cDCD liver transplant to DBD, no significant differences were observed in the incidence of NAS, patient and graft survival, comprehensive complication index, early allograft dysfunction, or acute kidney injury. Study protocol magnetic resonance cholangiopancreatography in cDCD patients showed no signs of subclinical biliary strictures. Evaluation of the Swedish national pilot of cDCD LTX with mandatory NRP shows comparable outcomes to a matched DBD cohort with 94.4% 1-year patient and graft survival and no incidence of NAS within the first year.
Clinical Outcomes Among High-Risk Primary Care Patients With Diabetic Kidney Disease
Authors: Bosworth Hayden B. , Patel Uptal D. , Lewinski Allison A. , Davenport Clemontina A. , Pendergast Jane , Oakes Megan , Crowley Matthew J. , Zullig Leah L. , Patel Sejal , Moaddeb Jivan , Miller Julie , Malone Shauna , Barnhart Huiman , Diamantidis Clarissa J. 
Published: July 2024

Background/Objective:
Slowing the progression of diabetic kidney disease (DKD) is critical. We conducted a randomized controlled trial to target risk factors for DKD progression.

Methods:
We evaluated the effect of a pharmacist-led intervention focused on supporting healthy behaviors, medication management, and self-monitoring on decline in estimated glomerular filtration rate (eGFR) for 36 months compared with an educational control.

Results:
We randomized 138 individuals to the intervention group and 143 to control. At baseline, mean (SD) eGFR was 80.7 (21.7) mL/min/1.73m2, 56% of participants had chronic kidney disease and a history of uncontrolled hypertension with a baseline SBP of 134.3 mm Hg. The mean (SD) decline in eGFR by cystatin C from baseline to 36 months was 5.0 (19.6) and 5.9 (18.6) mL/min/1.73m2 for the control and intervention groups, respectively, with no significant between-group difference (P=0.75).

Conclusions:
We did not observe a significant difference in clinical outcomes by study arm. However, we showed that individuals with DKD will engage in a pharmacist-led intervention. The potential explanations for a lack of change in DKD risk factors can be attributed to 5 broad issues, challenges: (1) associated with enrolling patients with low eGFR and poor BP control; (2) implementing the intervention; (3) limited duration during which to observe any clinical benefit from the intervention; (4) potential co-intervention or contamination; and (5) low statistical power.
Predictors of Health-Related Quality of Life in Younger Persons With a Fecal Ostomy and Inflammatory Bowel Disease
Authors: Werther Caitlin 
Published: July 2024

PURPOSE:
The purpose of this study was to determine predictors of health-related quality of life (HRQOL) in persons aged 18 to 40 years living with inflammatory bowel disease (IBD) and a fecal ostomy.

DESIGN:
Descriptive cross-sectional study.

SUBJECTS AND SETTING:
The sample comprised 98 participants recruited from online discussion boards/support groups for individuals living with IBD and an intestinal ostomy. More than three-quarters (76.5%) were female; 45.9% (n = 44) had lived with an ostomy for 2 years or less. Data were collected through an online survey made available from October 2018 to December 2018.

METHODS:
HRQOL was measured using the Healthy Days Core Module (Centers for Disease Control and Prevention HRQOL-4). Item 1 from the CDC HRQOL-4 represented the variable self-rated health (SRH). The subscales of bodily pain, general mental health, and vitality from the Short-Form 36 Health Survey and the subscales of ostomy function and body image/sexuality plus skin irritation item from the Young-Fadok Stoma Quality of Life (QOL) Scale were used to measure predictors of pain, psychological distress, fatigue, peristomal skin irritation, leakage of ostomy appliance, and body image/sexual disturbance. Correlational and hierarchical multiple linear regression analyses were conducted to complete hypotheses testing.

RESULTS:
Significant correlations were found between pain, fatigue, peristomal skin problems, psychological distress, SRH, and HRQOL. Pain, fatigue, psychological distress, and self-related health explained 53.2% of the variance in HRQOL based on hierarchical multiple linear regression and controlling for demographic variables such as marital and employment status.

CONCLUSIONS:
Findings suggest global disease symptoms of IBD in the form of pain, fatigue, and psychological distress and individual perception of health (SRH) are more important than transient ostomy symptoms of peristomal skin complications and leakage of ostomy appliance in predicting HRQOL. Individuals in this population regularly use online resources indicating a need to understand and gain insight into the information posted online in the management of the fecal ostomy and IBD.
The Correlation Between Comfort Level and Quality of Life in Female Patients With Urinary Incontinence
Authors: Gülnar Emel , Yuvanç Ercan , Çalışkan Nurcan 
Published: July 2024

PURPOSE:
The aim of this study was to develop a model to determine the correlation between comfort level and quality of life in women with UI.

DESIGN:
Cross-sectional, descriptive correlational research design with causal modeling.

SUBJECTS AND SETTING:
The study was conducted in the urology outpatient clinic of a university hospital in the Central Anatolia region of Turkey. The sample comprised 233 women admitted to the outpatient clinic between December 2017 and May 2018. Participants had a mean age of 52.5 (SD = 13.9) years.

METHODS:
Data were collected using a researcher-designed Descriptive Characteristics Form, the Incontinence Quality of Life (I-QOL) form, the Urinary Incontinence and Frequency Comfort Questionnaire (UIFCQ), and the Short Form-36 (SF-36). Multivariate correlations were analyzed using structural equation modeling; an AMOS covariance-based structural equation model was developed.

RESULTS:
The correlational pathway between I-QOL, UIFCQ, and SF-36 was statistically significant. As a result of the confirmed model, I-QOL scores were moderately correlated with SF-36 scores (r = .65, P = .001) and highly correlated with UIFCQ scores (r = .76, P = .001). Mean UIFCQ scores were moderately correlated with SF-36 scores (r = .66, P = .001). The structural equation modeling resulted in a model with a good fit.

CONCLUSIONS:
The higher the comfort level, the higher the UI-specific and health-related quality of life. Risk factors related to UI should be monitored, and necessary training and counseling should be provided to eliminate this common problem.
Spatial food webs in the Barents Sea: atlantification and the reorganization of the trophic structure
Authors: Jordán Ferenc , Capelli Greta , Primicerio Raul , Hidas András , Fábián Virág , Patonai Katalin , Bodini Antonio 
Published: July 2024

Climate change affects ecosystems at several levels: by altering the spatial distribution of individual species, by locally rewiring interspecific interactions, and by reorganizing trophic networks at larger scales. The dynamics of marine food webs are becoming more and more sensitive to spatial processes and connections in the seascape. As a case study, we study the atlantification of the Barents Sea: we compare spatio-temporal subsystems at three levels: the identity of key organisms, critically important interactions and the entire food web. Network analysis offers quantitative measurements, including centrality indices, trophic similarity indices, a topological measure of interaction asymmetry and network-level measures. We found that atlantification alters the identity of key species (boreal demersals becoming hubs), results in strongly asymmetric interactions (dominated by haddock), changes the dominant regulation regime (from bottom-up to wasp-waist control) and makes the food web less modular. Since the results of food web analysis may be quite sensitive to network construction, the aggregation of food web data was explicitly studied to increase the robustness of food web analysis. We found that an alternative, mathematical aggregation algorithm better preserves some network properties (e.g. density) of the original, unaggregated network than the biologically inspired aggregation into functional groups.
This article is part of the theme issue ‘Connected interactions: enriching food web research by spatial and social interactions’.
Erosion of fish trophic position: an indirect effect of fishing on food webs elucidated by stable isotopes
Authors: Agnetta Davide , Badalamenti Fabio , Sweeting Christopher J. , D'Anna Giovanni , Libralato Simone , Pipitone Carlo 
Published: July 2024

Fishing has significant trophodynamic impacts on marine communities, including reductions in the mean trophic position (TP) of the ecosystem resulting from a decrease in the abundance and size of species and individuals with high TPs. This study demonstrates the erosion of fish TP, an additional process that results in lower TP of individuals of a given size, which may exacerbate the effects of fishing on the food web. A stable isotope approach based on the tRophicPosition Bayesian method was used to quantify the TP of 12 target marine species at a given length, and compare their TP between fishery-restricted areas and trawled areas. The results show a difference in the TP of six benthic and apical nekto-benthic predators, which feed in the median at about 0.5 TP lower in trawled areas. It appears that current ‘fishing down marine food webs’ analyses may underestimate the trophic effects of fishing. Accounting for changes in trophodynamics of individuals at a given size is important to detect indirect effects through food web interactions. The application of a trawling ban may lead to the restoration of lost trophic structure; however, trophic changes may occur more slowly than changes in biomass.
This article is part of the theme issue ‘Connected interactions: enriching food web research by spatial and social interactions’.
Responses at various levels of ecological hierarchy indicate acclimation to sequential sublethal heatwaves in a temperate benthic ecosystem
Authors: Ito Maysa , Guy-Haim Tamar , Sawall Yvonne , Franz Markus , Buchholz Björn , Hansen Thomas , Neitzel Philipp , Pansch Christian , Steinhoff Tobias , Wahl Martin , Weinberger Florian , Scotti Marco 
Published: July 2024

Marine heatwaves have caused massive mortality in coastal benthic ecosystems, altering community composition. Here, we aim to understand the effects of single and sequential sublethal heatwaves in a temperate benthic ecosystem, investigating their disturbance on various levels of ecological hierarchy, i.e. individual physiology, trophic groups’ biomass and ecosystem carbon fluxes. To do so, we performed a near-natural experiment using outdoor benthic mesocosms along spring/summer, where communities were exposed to different thermal regimes: without heatwaves (0HW), with one heatwave (1HW) and with three heatwaves (3HWs). Gastropods were negatively impacted by one single heatwave treatment, but the exposure to three sequential heatwaves caused no response, indicating ecological stress memory. The magnitude of ecosystem carbon fluxes mostly decreased after 1HW, with a marked negative impact on mesograzers’ feeding, while the overall intensity of carbon fluxes increased after 3HWs. Consumers’ acclimation after the exposure to sequential heatwaves increased grazing activity, representing a threat for the macroalgae biomass. The evaluation of physiological responses and ecological interactions is crucial to interpret variations in community composition and to detect early signs of stress. Our results reveal the spread of heatwave effects along the ecological hierarchical levels, helping to predict the trajectories of ecosystem development.
This article is part of the theme issue ‘Connected interactions: enriching food web research by spatial and social interactions’.
Neighbourhood benthic configuration reveals hidden co-occurrence social diversity
Authors: Kininmonth Stuart , Ferrando Diana López , Becerro Mikel 
Published: July 2024

Ecological interactions among benthic communities are crucial for shaping marine ecosystems. Understanding these interactions is essential for predicting how ecosystems will respond to environmental changes, invasive species, and conservation management. However, determining the prevalence of species interactions at the community scale is challenging. To overcome this challenge, we employ tools from social network analysis, specifically exponential random graph modelling (ERGM). Our approach explores the relationships among animal and plant organisms within their neighbourhoods. Inspired by companion planting in agriculture, we use spatiotemporal co-occurrence as a measure of mixed species interaction. In other words, the variety of community interactions based on co-occurrence defines what we call ‘co-occurrence social diversity’. Our objective is to use ERGM to quantify the proportion of interactions at both the simple paired level and the more complex triangle level, enabling us to measure and compare co-occurrence social diversity. Applying our approach to the Spanish coastal zone across eight sites, five depths, and sunlit/shaded aspects, we discover that 80% of sessile communities, consisting of over a hundred species, exhibit co-occurrence social diversity, with 5% of species consistently forming associations with other species. These organism-level interactions probably have a significant impact on the overall character of the site.
This article is part of the theme issue ‘Connected interactions: enriching food web research by spatial and social interactions’.
Collective intelligence facilitates emergent resource partitioning through frequency-dependent learning
Authors: Ogino Mina , Farine Damien R. 
Published: July 2024

Deciding where to forage must not only account for variations in habitat quality but also where others might forage. Recent studies have suggested that when individuals remember recent foraging outcomes, negative frequency-dependent learning can allow them to avoid resources exploited by others (indirect competition). This process can drive the emergence of consistent differences in resource use (resource partitioning) at the population level. However, indirect cues of competition can be difficult for individuals to sense. Here, we propose that information pooling through collective decision-making—i.e. collective intelligence—can allow populations of group-living animals to more effectively partition resources relative to populations of solitary animals. We test this hypothesis by simulating (i) individuals preferring to forage where they were recently successful and (ii) cohesive groups that choose one resource using a majority rule. While solitary animals can partially avoid indirect competition through negative frequency-dependent learning, resource partitioning is more likely to emerge in populations of group-living animals. Populations of larger groups also better partition resources than populations of smaller groups, especially in environments with more choices. Our results give insight into the value of long- versus short-term memory, home range sizes and the evolution of specialization, optimal group sizes and territoriality.
This article is part of the theme issue ‘Connected interactions: enriching food web research by spatial and social interactions’.
BETA-HYDROXYBUTYRATE COUNTERACTS THE DELETERIOUS EFFECTS OF A SATURATED HIGH-FAT DIET ON SYNAPTIC AMPA RECEPTORS AND COGNITIVE PERFORMANCE
Authors: Rojas Rocío , Griñán-Ferré Christian , Castellanos Aida , Griego Ernesto , Martínez Marc , Navarro-López Juan de Dios , Jiménez-Díaz Lydia , Rodríguez-Álvarez José , del Cerro David Soto , Castillo Pablo E , Pallàs Mercè , Fadó Rut , Casals Núria 
Published: July 2024

AbstractThe ketogenic diet, characterized by high fat and low carbohydrates, has gained popularity not only as a strategy for managing body weight but also for its efficacy in delaying cognitive decline associated with neurodegenerative diseases and the aging process. Since this dietary approach stimulates the liver’s production of ketone bodies, primarily β-hydroxybutyrate (BHB), which serves as an alternative energy source for neurons, we investigated whether BHB could mitigate impaired AMPA receptor trafficking, synaptic dysfunction, and cognitive decline induced by metabolic challenges such as saturated fatty acids. Here, we observe that, in cultured primary cortical neurons, exposure to palmitic acid (200μM) decreased surface levels of glutamate GluA1-containing AMPA receptors, whereas unsaturated fatty acids, such as oleic acid and ω-3 docosahexaenoic acid (200μM), and BHB (5mM) increased them. Furthermore, BHB countered the adverse effects of palmitic acid on synaptic GluA1 levels in hippocampal neurons, as well as excitability and plasticity in hippocampal slices. Additionally, daily intragastric administration of BHB (100 mg/kg/day) for two months reversed cognitive impairment induced by a saturated high-fat diet (49% of calories from fat) in a mouse experimental model of obesity. In summary, our findings underscore the significant impact of fatty acids and ketone bodies on AMPA receptors abundance, synaptic function and neuroplasticity, shedding light on the potential use of BHB to delay cognitive impairments associated with metabolic diseases.