bluuebunny/crossref_metadata_2025_split huggingface dataset:
Possible association of ABCB1:c.3435T>C polymorphism with high-density-lipoprotein-cholesterol response to statin treatment - a pilot study.
Authors: Sałacka Anna , Bińczak-Kuleta Agnieszka , Kaczmarczyk Mariusz , Hornowska Iwona , Safranow Krzysztof , Clark Jeremy Simon Cabot 
Published: January 2015

The gene product ABCB1 (formerly MDR1 or P-glycoprotein) is hypothesized to be involved in cholesterol cellular trafficking, redistribution and intestinal re-absorption. Carriers of the ABCB1:3435T allele have previously been associated with decreases in ABCB1 mRNA and protein concentrations and have been correlated with changes in serum lipid concentrations. The aim of this study was to investigate possible association between the ABCB1:3435T>C polymorphism and changes in lipids in patients following statin treatment. Outpatients (n=130) were examined: 43 men (33%), 87 women (67%): treated with atorvastatin or simvastatin (all patients with equivalent dose of 20 or 40 mg/d simvastatin). Blood was taken for ABCB1:3435T>C genotyping, and before and after statin treatment for lipid concentration determination (total cholesterol, high-density-lipoprotein-cholesterol (HDL-C), triglycerides). Change (Δ) in lipid parameters, calculated as differences between measurements before and after treatment, were analyzed with multiple regression adjustments: gender, diabetes, age, body mass index, equivalent statin dose, length of treatment. Univariate and multivariate analyses showed significant differences in ΔHDL-C (univariate p=0.029; multivariate p=0.036) and %ΔHDL-C (univariate p=0.021; multivariate p=0.023) between patients with TT (-0.05 ± 0.13 g/l; -6.8% ± 20%; respectively) and CC+CT genotypes (0.004 ± 0.15 g/l; 4.1 ± 26%; respectively). Reduction of HDL-C in homozygous ABCB1:3435TT patients suggests this genotype could be associated with a reduction in the benefits of statin treatment.
Effect of topically applied sildenafil citrate on wound healing: experimental study
Authors: Gürsoy Koray , Oruç Melike , Kankaya Yüksel , Ulusoy Mustafa Gürhan , Koçer Uğur , Kankaya Duygu , Gürsoy Reyhan Neslihan , Çevik Özge , Öğüş Elmas , Fidanci Vildan 
Published: January 2015

Wound healing is a complex process that necessitates organization of different cell types and several signalling molecules. The aim of this study is to evaluate the effect of different concentrations of sildenafil citrate, which decreases cGMP degradation, on wound healing by secondary intention.
This study was performed using 25 Sprague Dawley rats weighing 200-250 grams. 4 dorsal defects were created. Four different treatment modalities which were 1% and 5% sildenafil citrate gel prepared with carbopol, pure carbopol gel without any drug in it and 0,9% NaCl solution; were applied to each lesion of the same rat. Randomly selected five rats (25 rats in total) were sacrificed on 3rd, 5th, 7th, 10th, and 14th days; and the effect of each modality was evaluated by means of defect area measurement, histopathological examination and measurement of tissue hydroxyproline levels.
Sildenafil citrate gel application decreased the defect areas in a dose independent manner starting from 3rd day and dose dependent manner after 7th day. By means of vascularization, sildenafil citrate increased vascularity starting from 3rd day. The strength of acute inflammation was superior in sildenafil groups starting from 5th day; and the amount and maturation of granulation in the wound bed, as well as the strength of chronic inflammation were superior in defects treated with sildenafil citrate as early as 7th day.
Diagnostic dilemma of parotid lipomas: imaging versus fine needle aspiration cytology
Authors: Arslan Ilker Burak , Uluyol Sinan , Genc Selahattin , Eruyar Tugrul , Bulgurcu Suphi , Cukurova Ibrahim 
Published: January 2015

Lipomas are common soft tissue neoplasms; however, they are found rarely in the parotid gland region. The purpose of this study was to analyze the diagnostic challenges of this rare condition. We performed a retrospective analysis of 11 patients with parotid lipomas, treated from November 2009 to February 2014. The mean age at diagnosis was 46.6±2.9 years, and the study population included 8 males and 3 females. Computed tomography (CT) and/or magnetic resonance imaging (MRI) were performed in radiological diagnosis. Fine needle aspiration (FNA) was performed in all cases (including two times in five patients, for a total of 16 biopsies) and results were diagnostic in four instances. Specificities of the CT, MRI, and FNA cytology tests were 100%, 100%, and 25% respectively. CT and/or MRI scans were more reliable than FNA cytologies for accurate diagnosis of parotid lipomas.
Extracorporeal shock waves lithotripsy versus retrograde ureteroscopy: is radiation exposure a criterion when we choose which modern treatment to apply for ureteric stones?
Authors: Pricop Catalin , Maier Adrian , Negru Dragos , Malau Ovidiu , Orsolya Martha , Radavoi Daniel , Serban Dragomir R 
Published: January 2015

The aim of this study is to compare two major urological procedures in terms of patient exposure to radiation. We evaluated 175 patients, that were subjected to retrograde ureteroscopy (URS) and extracorporeal shock waves lithotripsy (ESWL) for lumbar or pelvic ureteral lithiasis, at two urological departments. The C-arm Siemens (produced in 2010 by Siemens AG, Germany) was used for ureteroscopy. The radiological devices of the lithotripters used in this study in the two clinical centers had similar characteristics. We evaluated patient exposure to ionizing radiation by using a relevant parameter, the air kerma-area product (PKA; all values in cGy cm2), calculated from the radiation dose values recorded by the fluoroscopy device. PKA depends on technical parameters that change due to anatomical characteristics of each case examined, such as body mass index (BMI), waist circumference, and stone location. For the patients subjected to ESWL for lumbar ureteral lithiasis the mean of PKA (cGy cm2) was 509 (SD=180), while for those treated for pelvic ureteral lithiasis the mean of PKA was 342 (SD=201). In the URS group for lumbar ureteral lithiasis, the mean of PKA (cGy cm2) was 892 (SD=436), while for patients with pelvic ureteral lithiasis, the mean of PKA was 601 (SD=429). The patients treated by URS had higher exposure to ionizing radiation dose than patients treated by ESWL. The risk factors of higher radiation doses were obesity, exposure time, and localization of the stones.
An Entrained-Droplet Model for Prediction of Minimum Flow Rate for the Continuous Removal of Liquids From Gas Wells
Authors: Wang Zhibin , Bai Huifang , Zhu Suyang , Zhong Haiquan , Li Yingchuan 
Published: February 2015

Summary
Experimental studies show that liquid drop is deformed from initial spherical shape into ellipsoid shape in annular-mist flow, and the available critical Weber number WeCrit determined by the experiment can vary from 2.2 to 60 for low-viscosity liquid. On the basis of the force equilibrium and the critical-Weber-number-calculation method proposed by Azzopardi (1985), this paper develops a new model to predict minimum gas rate. This model introduces a parameter Ck,Wecrit that describes the effect of liquid-drop deformation and the maximum drop-size difference on the minimum gas rate. The effect of liquid-droplet coalescence is also considered indirectly. A function to predict drop-deformation magnitude for different critical Weber numbers is developed on the basis of energy conservation. The function-prediction results are in good agreement with experimental data from the literature and the predicted result from the drop deformation/breakup model, and the average absolute deviation is 6.1%. The Ck,Wecrit calculated by the new model increases with the increase of the pressure and liquid amount and it varies from 3.99 to 7.3, which means the critical gas velocity increases with the increase of the pressure and liquid amount. Numerous gas-well data were used for the validation of these entrained models, including data from 33 low-pressure gas wells (wellhead pressure: 0.26–3.41 MPa) from Coleman et al. (1991) and 91 high-pressure gas wells (wellhead pressure: 0.7–56 MPa) from Turner et al. (1969). The result shows the new entrained model has a good comprehensive performance in judging liquid-loading status in both high- and low-pressure gas wells.
Disease Activity in Ankylosing Spondylitis and Associations to Markers of Vascular Pathology and Traditional Cardiovascular Disease Risk Factors: A Cross-sectional Study
Authors: Berg Inger Jorid , van der Heijde Désirée , Dagfinrud Hanne , Seljeflot Ingebjørg , Olsen Inge Christoffer , Kvien Tore K. , Semb Anne Grete , Provan Sella A. 
Published: February 2015

Objective.To compare the risk of cardiovascular disease (CVD) in ankylosing spondylitis (AS) and population controls, and to examine the associations between disease activity and CVD risk.Methods.A cross-sectional study was done of patients with AS grouped according to Ankylosing Spondylitis Disease Activity Score (ASDAS) into ASDAS-high and ASDAS-low. Markers of vascular pathology, impaired endothelial function [asymmetric dimethylarginine (ADMA)], and arterial stiffness [augmentation index (AIx) and pulse wave velocity (PWV)], and traditional CVD risk factors [blood pressure, lipids, body mass index (BMI), CVD risk scores] were compared between AS and controls as well as across ASDAS-high versus ASDAS-low versus controls using ANCOVA analyses.Results.Altogether, 151 patients with AS and 134 controls participated. Patients had elevated ADMA (µmol/l) and AIx (%) compared to controls: mean difference (95% CI): 0.05 (0.03, 0.07), p < 0.001 and 2.6 (0.8, 4.3), p = 0.01, respectively. AIx increased with higher ASDAS level, p(trend) < 0.04. There were no significant group differences of PWV. BMI was higher in ASDAS-high compared to ASDAS-low (p = 0.02). Total cholesterol was lower in AS compared to controls, and lower with higher ASDAS, p(trend) = 0.02. CVD risk scores were similar across groups except for Reynolds Risk Score, where the ASDAS-high group had a significantly higher score, compared to both ASDAS-low and controls.Conclusion.Elevated ADMA and AIx in AS support a higher CVD risk in AS. Elevated AIx and BMI in AS with high ASDAS indicate an association between disease activity and CVD risk. Lower total cholesterol in AS may contribute to underestimation of CVD risk.
Urinary Albumin Excretion Is Increased in Patients with Rheumatoid Arthritis and Associated with Arterial Stiffness
Authors: Becetti Karima , Oeser Annette , Ormseth Michelle J. , Solus Joseph F. , Raggi Paolo , Stein C. Michael , Chung Cecilia P. 
Published: February 2015

Objective.Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease (CVD). High urinary albumin excretion is a risk factor for CVD in the general population, but its role in atherosclerosis in patients with RA is not well defined.Methods.We determined the urine albumin to creatinine ratio (UACR) in 136 patients with RA and 79 controls. Individuals with diabetes or a clinical history of CVD were excluded. We measured coronary artery calcium (CAC) with electron beam computer tomography and augmentation index (AIx) using pulse wave analysis. In patients with RA, erythrocyte sedimentation rate and concentrations of vascular cell adhesion protein-1 (VCAM-1), interleukin 10 (IL-10), C-reactive protein, IL-6, tumor necrosis factor-α, and cystatin-C were measured and results correlated with UACR.Results.Patients with RA had higher UACR [median (interquartile range): 7.6 (4.0–15.5) mg/g] than control subjects: 5.6 (3.3–9.0) mg/g; p = 0.02. The presence of CAC was not associated with UACR in RA or control subjects. In patients with RA, UACR was significantly correlated with AIx (rho = 0.24, p = 0.01), higher levels of VCAM-1 (rho = 0.2, p = 0.01), and lower levels of IL-10 (rho = −0.2, p = 0.02). The association between AIx and higher UACR remained significant in multivariate analysis [β coefficient of 1.5 (95% CI 0.1–2.8), p = 0.03 that adjusted for age, sex, and race].Conclusion.Urinary albumin excretion was higher in patients with RA than controls and correlated with increased arterial stiffness, higher VCAM-1, and lower IL-10 concentrations.
Fonetične in ortografske interference pri govorjeni romunščini v Španiji
Authors: Jieanu Ioana , Baciu Eugenia 
Published: February 2015

Članek Fonetične in ortografske interference pri govorjeni romunščini v Španiji prikaže z dvojne (fonetične in ortografske) perspektive nekaj pojavov, ki so nastali pri romunsko španskih stikih. Namen raziskave fonetičnega in ortografskega vpliva španščine na romunščino je identifikacija lingvističnih posledic, ki bi jih množično priseljevanje Romunov v Španijo lahko imelo.Pri analizi romunskega jezika priseljencev v romunskih skupnostih iz Španije smo zaznali dva načina fonetičnega prilagajanja: prilagajanje španskih izposojenk romunskemu fonetičnemu sistemu in prilagajanje romunskih besed španskemu fonetičnemu sistemu. Z vzporednim preučevanjem zvočnih in pisanih zapisov enajstih romunskih študentov v Španiji, v Castellón de la Plana, smo ugotovili, da se španske izposojenke fonetično prilagodijo romunskemu jeziku, pri pisavi pa te prilagoditve ne zaznamo.
Interprétation générique des indéfinis français et slovènes (Generična interpretacija nedoločnih določevalnikov v francoščini in slovenščini)
Authors: Struna Berden Tatjana 
Published: February 2015

Pričujoči članek se osredotoča na kontrastivno analizo francoskih nedoločnih določevalnikov in slovenskih samostalniških in pridevniških zaimkov. Članek se omejuje na standardno generično in delno generično interpretacijo izbranih nedoločnih zaimkov (tout(e/s), chaque, quelque, plusieurs, certains in vsi, vsak, nekaj, več, nekateri) in proučuje njihov semantični, sintaktični in pragmatični vpliv na obe interpretaciji.V primerjavi obeh interpretacij proučujemo tudi, kako lahko položaj nedoločnega določevalnika, glede na to, ali se pojavlja v osebku ali predmetu, vpliva na končno interpretacijo. Analizirani so tudi primeri, iz katerih je razvidna nesprejemljivost ponovitve enega nedoločnega določevalnika v istem stavku, in primeri, kjer je včasih nemogoče ohraniti enako interpretacijo v obeh jezikih.Namen članka je pokazati podobnosti in razlike generične interpretacije v obeh jezikih. Kljub temu, da francoščina ima člen s katerim lažje izraža generičnost kot slovenščina, ki členov nima, pa v nobenem od jezikov ne obstajajo specifična jezikovna znamenja za izražanje generičnosti. Prikazano je, da na generičnost ne vpliva oblika, temveč v veliki meri interpretacija (konteksta in situacije) stavka.
Kako sladka so francoska vina – analiza napak študentov v prevodih besedil s področja vin in vinske kulture
Authors: Dobnik Nadja 
Published: February 2015

V okviru dodiplomskega študija prevajalstva na Oddelku za prevajalstvo FF je pri prevajanju iz francoščine v slovenščino ena rdečih niti tema vin in vinske kulture. Vina so neizogibni del francoske kulture in gospodarstva, pomembno vlogo pa imajo tudi v slovenskem prostoru, zato prevajanje besedil s tega področja pomeni obenem vpogled v družbo, kulturo in gospodarstvo ter razmislek o številnih podobnostih in razlikah.Pri spremljanju dela študentov več generacij (1999 do 2011) in analizi njihovih prevodov se je izkazalo, da se poleg težav, za katere smo predvidevali, da jih bodo študenti naredili in so bile del didaktičnih ciljev predmeta, redno pojavljajo tudi napake, ki jih po naših predvidevanjih študenti ne bi smeli narediti. V članku so prikazane težave in napake študentov pri prevajanju avtentičnega besedila »Caractéristiques des vins d'Alsace« (Značilnosti alzaških vin). Analiza napak je pokazala na kompleksnost prepletanja jezikovnih in pomenskih napak, ki so delno sicer posledica slabe jezikovne in besedilne kompetence študentov, zlasti pa opozarjajo na pomanjkljivo tematsko-vsebinsko in kulturno kompetenco študentov.
Phraseme und Sprichwörter in offiziellen Dokumenten des slowenischen Bildungssystems (Frazemi in pregovori v uradnih dokumentih slovenskega šolskega sistema)
Authors: Kacjan Brigita , Jazbec Saša 
Published: February 2015

Der Beitrag behandelt ein interessantes und bedeutendes, aber bisher vernachlässigtes Thema, das Vorhandensein von Phrasemen und Sprichwörtern in den slowenischen Lehrplänen und/oder Wissenskatalogen. Dabei handelt es sich um offizielle nationale Dokumente, die auf der Makroebene den Rahmen des Sprachenunterrichts abstecken und in die auch Phraseme und Sprichwörter gehören, geht es dabei doch um natürliche, polylexikale, frequente, stabile sprachliche Einheiten, für die die Idiomatizität charakteristisch ist. Sie stellen einen bedeutenden Teil der Alltagssprache dar und man würde erwarten, dass sie dementsprechend auch in den Lehrplänen/Wissenskatalogen für die Sprachfächer in der gesamten Vertikale des slowenischen Schulsystems vertreten sein werden. Im empirischen Teil, in dem Ausschnitte aus insgesamt 11 Lehrplänen/Wissenskatalogen angeführt werden, zeigt sich, dass Phraseme und Sprichwörter nur in einem sehr bescheidenen Ausmaße, unsystematisch und sporadisch vorkommen, dass die diesbezügliche Terminologie nicht einheitlich ist und dass die didaktischen Richtlinien häufig nur angedeutet sind. Diese Darstellung wird im Fazit abgerundet, wo auch Möglichkeiten zur Behebung dieses Missstands aufgezeigt werden. Prispevek obravnava zanimivo in pomembno, a doslej prezrto temo, to je zastopanost frazemov skupaj s pregovori v učnih načrtih in/ali katalogih znanja. Ti dokumenti so uradni nacionalni dokumenti, ki določajo okvire pouka na makroravni. Vanje sodijo tudi frazemi vključno s pregovori, saj gre za naravne več besedne, frekventne, stabilne jezikovne enote, za katere je značilna idiomatičnost. Kot take so pomemben del vsakdanjega jezka in pričakovali bi, da so torej posledično ustrezno zastopani, obravnavani v učnih načrtih in/ali katalogih znanja za jezikovne predmete na različnih stopnjah celotne vertikale izobraževanja. V empiričnem delu, kjer so nanizani izseki iz skupno 11 učnih načrtov ali katalogov znanja, se je pokazalo, da so frazemi in pregovori zelo skromno zastopani, da se pojavljajo nesistematično, sporadično, da je terminološki aparat neenoten, didaktični postopki pa pogosto zgolj nakazani. Tak prikaz stanja je zaokrožen v zaključku, kjer so nakazane še možnosti za izboljšanje ugotovljenega stanja.
Amici d'Italia (livello 1 e 2)
Authors: Mertelj Darja 
Published: February 2015

Ercolino, Elettra & Pellegrino Anna T. (2013): Amici d'Italia (livello 1), libro dello studente. Loreto: ELI, ISBN 978-88-536-1511-4, mehka vezava, 144 strani, 14,50 EUR Ercolino, Elettra & Pellegrino Anna T. (2013): Amici d'Italia (livello 1), eserciziario. Loreto: ELI, ISBN 978-88-536-1512-1, mehka vezava, 80 strani, 11,00 EUR Ercolino, Elettra & Pellegrino Anna T. (2013): Amici d'Italia (livello 1), guida. Loreto: ELI, ISBN 978-88-536-1513-8, mehka vezava, 160 strani, 22,80 EUR Ercolino, Elettra & Pellegrino Anna T. (2013): Amici d'Italia (livello 2), libro dello studente. Loreto: ELI, ISBN 978-88-536-1515-2, mehka vezava, 144 strani, 14,50 EUR Ercolino, Elettra & Pellegrino Anna T. (2013): Amici d'Italia (livello 2), eserciziario. Loreto: ELI, ISBN 978-88-536-1516-9, mehka vezava, 80 strani, 11,00 EUR Ercolino, Elettra & Pellegrino Anna T. (2013): Amici d'Italia (livello 2), guida. Loreto: ELI, ISBN 978-88-536-1517-6, mehka vezava, 160 strani, 22,80 EUR
Collection of Change Management Models – An Opportunity to Make the Best Choice from the Various Organizational Transformational Techniques
Authors: Kazmi Syeda Asiya Zenab , Naarananoja Marja 
Published: February 2015

AbstractPresent day’s crucial corporate competition proving the real time presence of ‘Darwin’s theory - Survival of the fittest’ in the global industrial scenes. Consequently, the managers are pressed hard to take smart steps for organizational continuous improvement. The above causes organizational chaos, since humans have the innate habit to resist the change.The article suggests the logic over the change leader’s selection of the best suited transformational criteria from the variety of change management models for smart organizational transformation process. The study results support the selection of ADKAR Model being one of the best to deal with the OSUVA case conditions due to having an ability to highlight the problem areas at each change process stage through barrier point identification perspective.
Board of Directors and Remuneration in Indonesian Banking
Authors: Endraswati Hikmah , Suhardjanto Djoko , Krismiaji  
Published: February 2015

AbstractThis research examines the effect of commissioner and remuneration committee characteristics on the remuneration in the banking sector of Indonesia. Using a sample of 18 banks for the fiscal year that ends on December 31 2006 through 2012, this study finds evidence of negative impact of gender and number of meeting on the remuneration. With respect of size as a control variable, this study proves a positive impact on the remuneration.
The keynesian system: fiscal and monetary policy guidelines
Authors: Hiç-Birol Özlen , Hiç Gencer Ayşen 
Published: February 2015

AbstractIn this article we shall try to establish the guidelines of the Keynesian fiscal and monetary policies. In order to better understand the Keynesian macroeconomic system it is necessary to go briefly over the Classical economics in the pre-Keynesian period and the fiscal and monetary policies based on those analyses. While principally dwelling on the Keynesian macroeconomic system and the fiscal and monetary policies based on this system, we think we have some grounds about the significance of the subject. Firstly, the Keynesian analyses keep holding the balance of power in the theoretical field even in the post-Keynes era, and constitute the foundation of the macroeconomic textbooks. Secondly, despite the economic conditions of these days which have gone through many changes, and the emergence of anti-Keynesian views, the governments and monetary authorities (Central Banks) both in Europe and in the States, still implement – cautiously– fiscal and monetary policies in accordance with the Keynesian principles. In effect during Reagan era in the States and M. Thatcher in Britain, policies under the influence of Monetarism had been applied, however, since inflation was not prevented and there was an increase in unemployment, these policies were forsaken and moderate Keynesian policies were implemented low-key. But criticisms coming from both Monetarists and particularly New Classical economists forced fundamental methodological and assumptive changes in Keynesianism since the ‘80s; the school that emerged in the USA is called the New Keynesian Economics, in England the Post-Keynesian Economics.