bluuebunny/crossref_metadata_2025_split huggingface dataset:
Untersuchungen über fossile Buchenhölzer Beiträge zu einer Monographie der Gattung Fagoxylon Stopes & Fujii
Authors: Süss Herbert 
Published: July 2024

ZusammenfassungFür die Gattung Fagoxylon Stopes & Fujii (1911) wird eine neugeafaβte und erweiterte Diagnose aufgestellt. Nach vorliegendem Material werden vier Arten von Fagoxylon teils erstmals, teils auf Grund einer Nachuntersuchung älteren Materials nou beschrieben. Die Funde stammen aus der UdSSR, der VR Ungarn, der VR Polen und aus Island und sind eozänen bzw. miozänen Alters. Nach einer zusammenfassenden Diskussion über die holzanatomischen Eigenschaften der fossilen Buchen wird eine kritische Übersicht über alle bisher bekannten, mit der Gattung Fagns verglichenen Holzfossilien gegeben.
A survey of the ruderal plant communities of Western Slovakia. II1
Authors: Eltáš Pavol 
Published: July 2024

SummaryShort characteristics of the plant nitrophilous communities occurring in Western Slovakia, Czeehoslovakia, are presented in the form of the syntaxonomical survey. This second part of the survey contains about 100 ruderal associations belonging to the classes Polygono‐Chenopodietea (Lohmeyer, J. et R. Tx.) Eltáš 1984, Meliloto‐Artemisietea absinthii Eltáš 1980, Artemisietea vulgaris Lohmeyer, Preising et Tx. in Tx, 1950 om. Eltáš 1981 Agropyretea repentis Oberdorfer, Th. Müller et Görs in Oberd. et al. 1967, Polygono‐Poetea annuae Rivas‐Martínez 1975 and Molinio‐Arrhenatheretea Tx. 1937 em. 1970.Zusammen fassungIn Form einer syntaxonomischen Übersieht werden kurze synmorphologisehe, synökologische und syngonetische Charakteristiken der nitrophilen Pflanzengesellsehaften und Angabon über ihre Verbreitung in der Westslowakei eingeführt. Der vorliegende zweite Teil der Übersicht enthält etwa 100 Assoziationen die zu den Klassen Polygono‐Chenopodietea (Lohmeyer, J. et R. Tx.) Eltáš 1984, Meliloto‐Artemisietea absinthii Eltáš 1980, Artemisietea vulgaris Lohmeyer, Preising et Tx. in Tx. 1950 em. Eltáš 1981, Agropyretea repentis Oberdorfer, Th. Müller et Görs in Oberd. et al. 1967, Polygono‐Poetea annuae Rivas‐Martínez 1975 und Molinio‐Arrhenatheretea Tx. 1937 em. 1937 gehören.
Beitrag zur Kenntnis der anthropogenen Vegetation der Tropenstadt Puerto Maldonado (Peru)
Authors: Gutte P. , Müller G. K. 
Published: July 2024

SummaryIn this publication the authors give a description of the ruderal plant communities of the tropical City of Puerto Maldonado (Dpt. Madre de Dios, Peru) and some floristical remarks to the vegetation of the “matorral” (anthropogenous bush).
Vegetation between Taif and El‐Shafa highland (Asir mountains, Saudi Arabia)
Authors: Zayed K. M. , El‐Karemy A. R. 
Published: July 2024

SummaryThis study reports on a survey of the vegetation between Taif and El‐Shafa highland (Asir mountains — Saudi Arabia), a distance of about 45 km with a sharp rise from 1630 to 2085 m above sea level. Climatic data of the area are presented. Thirteen plant communities in four distinguished sectors are identified. These are: 1) Low land sector with communities of Verbesina encelioides, Acacia gerrardii, A. tortilis — A. ehrenbergiana and Commicarpus grandiflorus; 2) Gentle sloped sector with four communities of Publicaria crispa — Euryops arabicus, Indigofera spinosa — Lavandula pubescens, Dodonaea viscosa — Psiadia punctulata and Clutea myricoides —‐ Olea chrysophylia; 3) subsumit sector with 2 communities namely: Acacia gerrardii — Olea chrysophylla and Juniperus excelsa — Olea chrysophylia; 4) Summit sector with 3 communities: Juniperus excelsa, Juniperus excelsa — Acacia negrii and Tarconanthus camphoratus — Juniperus excelsa. 128 species of vascular plants, belonging to 42 families, are recorded. Relations between the different sectors and their communities are explored.
A new species of Salvia from Iraq1
Authors: Al‐Musawi A. H. E. , Weinert E. 
Published: July 2024

SummarySalvia arabica Al‐Musawi et Weinert spec. nov. is distinctive on account of its wide, cordate, subcircular leaves; white, creamy, large and very conspicuous bracts; long and short, glandular and eglandular, dense hairs and pale yellow corollas with their ventricose throats. The species is native on the hill sides in eastern Iraq, S. W. Asia.
Study of some taxa from the range of Chenopodium ficifolium Sm.
Authors: Dvořák F. 
Published: July 2024

SummaryChromosome sets of Chenopodium ficifolium Sm. differ in chromosome number (2n = 18, 36) and in the confidence interval of the mean length of one chromosome.Chenopodium ficifolium Sm., grown in populations out of the seeds of Chenopodium ficifolium × suecicum (2n = 18, 36) and Chenopodium fallax × ficifolium (2n = 54, 54 + 1), has evidently after a backcrossing an introgression of genes of another species.
Die Verbreitung des Wermuts (Artemisia absinthium L.) und einige phytogeographische Beobachtungen in bezug zur frühhistorischen Besiedlung Böhmens
Authors: Toman M. 
Published: July 2024

ZusammenfassungIn der Arbeit wird der Bezug zwischen den frühhislorischen Siedlungsregionen und der Verbreitung des Wermuts (Artemisia absinthium) innerhalb der Gemeinden beschrieben. Es wurde die Verbreitung der Art auf diesen Fundplätzen in Böhmen festgestellt Auf dieser Basis wurde eine Revision der frühhistorischen Besiedlung Böhmens vorgenommen.In Böhmen wurden 14 oder 15 frühhistorische Stammesgebiete nachgewiesen. Es wurde begründet, warum diese Anzahl wahrscheinlich endgültig ist. Zugleich wurde die spezifische Funktion des böhmischen Xerothermgebiets bei der Besiedlung sowie die Besiedlungsfeindlichkeit einer Landschaft mit dem Vorkommen obligater Halophyten geschildert. Mittels Vergleich über weitere Beobachtungen wurde abgeleitet, daß einige Siedlungsenklaven wohl bereits in vorslawischer Zeit entstanden sind (die ursprünglichen Einwohner wurden slawisiert), andere hingegen wurden erst mit der Zuwanderung der slawischen Stämme gegründet. Der Wald More wurde lokalisiert.
CircCUL1 inhibits trophoblast cell migration and invasion and promotes cell autophagy by sponging hsa‐miR‐30e‐3p in fetal growth restriction via the ANXA1/PI3K/AKT axis
Authors: Yang Tong , Hu Jianguo , Zhang Lei , Liu Li , Pan Xin , Zhou Yanqiu , Wu Yi , Shi Xian , Obiegbusi Chidera N. , Dong Xiaojing 
Published: July 2024

AbstractFetal growth restriction (FGR) severely affects the health outcome of newborns and represents a major cause of perinatal morbidity. The precise involvement of circCULT1 in the progression of FGR remains unclear. We performed next‐generation sequencing and RT‐qPCR to identify differentially expressed circRNAs in placental tissues affected by FGR by comparing them with unaffected counterparts. Edu, flow cytometry, and transwell assay were conducted to detect HTR8/SVneo cell's function in regard to cell proliferation, migration, and invasion. The interaction between circCUL1 and hsa‐miR‐30e‐3p was assessed through dual‐luciferase reporter assays, validation of the interaction between circCUL1 and ANXA1 was performed using RNA pulldown and immunoprecipitation assays. Western blot analysis was performed to evaluate protein levels of autophagy markers and components of the PI3K/AKT signaling pathway. A knockout (KO) mouse model was established for homologous mmu‐circ‐0001469 to assess fetal mouse growth and development indicators. Our findings revealed an upregulation of circCUL1 expression in placental tissues from patients with FGR. We found that suppression of circCUL1 increased the trophoblast cell proliferation, migration, and invasion, circCUL1 could interact with hsa‐miR‐30e‐3p. Further, circCUL1 stimulated autophagy, modulating trophoblast cell autophagy via the ANXA1/PI3K/AKT pathway, and a notable disparity was observed, with KO mice displaying accelerated embryo development and exhibiting heavier placentas in comparison to wild‐type C57BL/6 mice. By modulating the ANXA1/PI3K/AKT signaling pathway through the interaction with hsa‐miR‐30e‐3p, circCUL1 promotes autophagy while concurrently suppressing trophoblast cell proliferation, migration, and invasion. These findings offer novel insights into potential diagnostic markers and therapeutic targets for FGR research.
A new computed tomography‐based approach to quantify swallowing muscle volume by measuring tongue muscle area in a single slice
Authors: Hurtado‐Oliva Javier , Zwart Aniek T. , Vister Jeroen , van der Hoorn Anouk , Steenbakkers Roel J.H.M. , Wegner Inge , Halmos Gyorgy B. 
Published: July 2024

AbstractBackgroundMeasuring the swallowing muscle mass with volume measurements is complex and time intensive; therefore, it is not used in clinical practice. However, it can be clinically relevant, for instance, in the case of sarcopenic dysphagia. The aim of the study was to develop a feasible and clinically applicable method to measure swallowing muscle mass.MethodsData from 10 head and neck cancer patients were collected from the Oncological Life Study data‐biobank of the University Medical Center Groningen. The pharyngeal constrictor, genioglossus, mylohyoid and geniohyoid complex muscles, as well as the tongue complex muscles, were delineated manually on routinely performed head and neck computed tomography scans. Axial and sagittal planes were used for volume and area measurements, respectively. Muscle density measurements were performed with and without Hounsfield unit thresholding. Correlations were assessed by Pearson correlation coefficients, and interobserver reliability was measured using intra‐class correlation coefficients (ICCs).ResultsSignificant differences were observed between sagittal area measurements with and without Hounsfield unit thresholds for pharyngeal constrictor, tongue complex and the sum of the swallowing muscles (t > 6; P‐value < 0.001). Stronger correlations emerged without Hounsfield unit thresholding. Strong positive and significant correlations were found between the total swallowing muscle mass volume and the sagittal area of the tongue complex muscles (r = 0.87, P‐value < 0.05) and the sum of the sagittal areas of the pharyngeal constrictor and tongue complex muscles (r = 0.85, P‐value < 0.05). The use of the Hounsfield unit threshold weakened correlations. Interobserver reliability was assessed and found to be fair to good for the pharyngeal constrictor muscle (ICC = 0.68, P‐value < 0.05), excellent for the tongue complex muscles (ICC = 0.98, P‐value < 0.05) and excellent for the total swallowing muscle area (ICC = 0.96, P‐value < 0.05).ConclusionsSingle‐slice delineation of the sagittal area of tongue complex muscle and pharyngeal constrictor muscle is a promising, fast, simple and clinically applicable method for measuring the total volume of the swallowing muscle mass in head and neck cancer patients without Hounsfield unit thresholding. These advancements and findings would help in the early and accurate diagnosis of definitive sarcopenic dysphagia.
Fetal thymus size in pregnant women with Hashimoto disease
Authors: Kasap Esin , Saglam Ceren , Torun Raziye , Turkler Can , Gur Esra Bahar , Güleç Ebru Sahin , Bozgeyik Mehmet Bora 
Published: July 2024

AbstractPurposeThis study compared fetal thymic‐thoracic ratios and fetal thymus transverse diameter measurements in pregnant women with Hashimoto's thyroiditis (HT) and non‐immune hypothyroidism.MethodsThe study included a total of 141 pregnant women in three groups: 41 with HT, 50 with non‐immune hypothyroidism, and 50 healthy individuals. Fetal thymus transverse diameter and thymic‐thoracic ratio were compared between these groups.ResultsThe mean fetal thymic‐thoracic ratio was greater in pregnant women with HT than in the healthy controls (p = 0.031). Mean fetal thymus transverse diameter showed no statistically significant difference between the groups.ConclusionsMaternal HT was associated with an increased fetal thymic‐thoracic ratio. More comprehensive studies are needed on this subject.
Framework for managing inappropriate behavior in clinical dental learning environments
Authors: Al‐Jewair Thikriat , Scates Jessica , Stephan Eugena , Chin Kit‐Wells Meelin D. 
Published: July 2024

AbstractBackgroundWorkplace violence (WPV), such as physical violence, harassment, intimidation, or other threatening behavior, commonly occurs within healthcare settings including dentistry. The objective of this study was to analyze the behavioral and environmental factors contributing to WPV, determine its prevalence within one dental institution, and develop a WPV prevention and management protocol that is dental specific.MethodsTo identify factors that impact WPV occurrence, the PRECEDE–PROCEED planning model was employed. A pilot cross‐sectional survey was then conducted among faculty, staff, and dental learners (students/residents) to evaluate the prevalence of WPV incidents experienced and witnessed over the past year. The survey also assessed the locations where incidents took place, their type, and the strategies employed to manage them. A comprehensive protocol aimed at preventing and managing WPV in dental settings was subsequently developed.ResultsMultiple factors influence the occurrence of WPV. The prevalence of experienced and witnessed WPV incidents was 22% and 24% among faculty/staff and 7% and 5% among learners, respectively. Verbal aggression was the most common type of WPV. Most respondents lacked awareness of the available reporting mechanisms for WPV. A WPV prevention and management protocol was developed, consisting of five steps: intervene, report, document, access support services, and resolve (IRDAR).ConclusionsAdministrators must have a comprehensive understanding of the prevalence of violence in their workplace and the underlying factors that contribute to it in order to take appropriate action. IRDAR is a clearly defined and easily implemented protocol designed for preventing and managing WPV in dental learning environments.
A rare pediatric patient of anti‐IgLON5 encephalitis with epileptic seizures as the first symptom
Authors: Xue Jiao , Song Zhenfeng , Zhao Hongshan , Yi Zhi , Li Fei , Yang Chengqing , Liu Kaixuan , Zhang Ying 
Published: July 2024

AbstractBackgroundAnti‐IgLON5 encephalitis was a rare neurological and heterogeneous disorder, which was mainly found in adults. Epileptic seizures related to anti‐IgLON5 disease were rarely reported.MethodsNeural antibodies associated with autoimmune encephalitis in serum and cerebrospinal fluid (CSF) were tested using cell‐based assays (CBA) with immunofluorescence double staining. The antibodies in serum were further confirmed by tissue‐based assay (TBA) with rat brain and kidney tissue.ResultsWe reported a pediatric case presented with epileptic seizures, cognitive impairments, and sleep disorders. Autoantibody screening showed anti‐IgLON5 antibody IgG (1:100+) and anti‐NMDAR antibody IgG (1:10+) in the serum. She was diagnosed as anti‐IgLON5 encephalitis. Her conditions improved rapidly by treated with intravenous immunoglobulin and high dose intravenous methylprednisolone.ConclusionWe described the second pediatric case with anti‐IgLON5 encephalitis, who was also the first presented with epileptic seizures as the initial presentation. Anti‐IgLON5 encephalitis might have mild manifestations. For patients with new onset seizures associated with cognitive impairments and sleep disturbances, anti‐IgLON5 antibody should be tested as early, even in children.
Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation
Authors: Beaumont Joël E. J. , Barbeau Lydie M. O. , Ju Jinzhe , Savelkouls Kim G. , Bouwman Freek G. , Zonneveld Marijke I. , Bronckaers Annelies , Kampen Kim R. , Keulers Tom G. H. , Rouschop Kasper M. A. 
Published: July 2024

AbstractHypoxia is a common feature of solid tumours and activates adaptation mechanisms in cancer cells that induce therapy resistance and has profound effects on cellular metabolism. As such, hypoxia is an important contributor to cancer progression and is associated with a poor prognosis. Metabolic alterations in cells within the tumour microenvironment support tumour growth via, amongst others, the suppression of immune reactions and the induction of angiogenesis. Recently, extracellular vesicles (EV) have emerged as important mediators of intercellular communication in support of cancer progression. Previously, we demonstrated the pro‐angiogenic properties of hypoxic cancer cell derived EV. In this study, we investigate how (hypoxic) cancer cell derived EV mediate their effects. We demonstrate that cancer derived EV regulate cellular metabolism and protein synthesis in acceptor cells through increased activation of mTOR and AMPKα. Using metabolic tracer experiments, we demonstrate that EV stimulate glucose uptake in endothelial cells to fuel amino acid synthesis and stimulate amino acid uptake to increase protein synthesis. Despite alterations in cargo, we show that the effect of cancer derived EV on recipient cells is primarily determined by the EV producing cancer cell type rather than its oxygenation status.
Characterisation of LPS+ bacterial extracellular vesicles along the gut‐hepatic portal vein‐liver axis
Authors: Jain Heetanshi , Kumar Ashish , Almousa Sameh , Mishra Shalini , Langsten Kendall L. , Kim Susy , Sharma Mitu , Su Yixin , Singh Sangeeta , Kerr Bethany A. , Deep Gagan 
Published: July 2024

AbstractGut microbiome dysbiosis is a major contributing factor to several pathological conditions. However, the mechanistic understanding of the communication between gut microbiota and extra‐intestinal organs remains largely elusive. Extracellular vesicles (EVs), secreted by almost every form of life, including bacteria, could play a critical role in this inter‐kingdom crosstalk and are the focus of present study. Here, we present a novel approach for isolating lipopolysaccharide (LPS)+ bacterial extracellular vesicles (bEVLPS) from complex biological samples, including faeces, plasma and the liver from lean and diet‐induced obese (DIO) mice. bEVLPS were extensively characterised using nanoparticle tracking analyses, immunogold labelling coupled with transmission electron microscopy, flow cytometry, super‐resolution microscopy and 16S sequencing. In liver tissues, the protein expressions of TLR4 and a few macrophage‐specific biomarkers were assessed by immunohistochemistry, and the gene expressions of inflammation‐related cytokines and their receptors (n = 89 genes) were measured using a PCR array. Faecal samples from DIO mice revealed a remarkably lower concentration of total EVs but a significantly higher percentage of LPS+ EVs. Interestingly, DIO faecal bEVLPS showed a higher abundance of Proteobacteria by 16S sequencing. Importantly, in DIO mice, a higher number of total EVs and bEVLPS consistently entered the hepatic portal vein and subsequently reached the liver, associated with increased expression of TLR4, macrophage markers (F4/80, CD86 and CD206), cytokines and receptors (Il1rn, Ccr1, Cxcl10, Il2rg and Ccr2). Furthermore, a portion of bEVLPS escaped liver and entered the peripheral circulation. In conclusion, bEV could be the key mediator orchestrating various well‐established biological effects induced by gut bacteria on distant organs.
The Association Between Tumor Radiomic Analysis and Peritumor Habitat‐Derived Radiomic Analysis on Gadoxetate Disodium‐Enhanced MRI With Microvascular Invasion in Hepatocellular Carcinoma
Authors: Wang Cheng , Wu Fei , Wang Fang , Chong Huan‐Huan , Sun Haitao , Huang Peng , Xiao Yuyao , Yang Chun , Zeng Mengsu 
Published: July 2024

BackgroundHepatocellular carcinoma (HCC) has a poor prognosis, often characterized by microvascular invasion (MVI). Radiomics and habitat imaging offer potential for preoperative MVI assessment.PurposeTo identify MVI in HCC by habitat imaging, tumor radiomic analysis, and peritumor habitat‐derived radiomic analysis.Study TypeRetrospective.SubjectsThree hundred eighteen patients (53 ± 11.42 years old; male = 276) with pathologically confirmed HCC (training:testing = 224:94).Field Strength/Sequence1.5 T, T2WI (spin echo), and precontrast and dynamic T1WI using three‐dimensional gradient echo sequence.AssessmentClinical model, habitat model, single sequence radiomic models, the peritumor habitat‐derived radiomic model, and the combined models were constructed for evaluating MVI. Follow‐up clinical data were obtained by a review of medical records or telephone interviews.Statistical TestsUnivariable and multivariable logistic regression, receiver operating characteristic (ROC) curve, calibration, decision curve, Delong test, K‐M curves, log rank test. A P‐value less than 0.05 (two sides) was considered to indicate statistical significance.ResultsHabitat imaging revealed a positive correlation between the number of subregions and MVI probability. The Radiomic‐Pre model demonstrated AUCs of 0.815 (95% CI: 0.752–0.878) and 0.708 (95% CI: 0.599–0.817) for detecting MVI in the training and testing cohorts, respectively. Similarly, the AUCs for MVI detection using Radiomic‐HBP were 0.790 (95% CI: 0.724–0.855) for the training cohort and 0.712 (95% CI: 0.604–0.820) for the test cohort. Combination models exhibited improved performance, with the Radiomics + Habitat + Dilation + Habitat 2 + Clinical Model (Model 7) achieving the higher AUC than Model 1–4 and 6 (0.825 vs. 0.688, 0.726, 0.785, 0.757, 0.804, P = 0.013, 0.048, 0.035, 0.041, 0.039, respectively) in the testing cohort. High‐risk patients (cutoff value >0.11) identified by this model showed shorter recurrence‐free survival.Data ConclusionThe combined model including tumor size, habitat imaging, radiomic analysis exhibited the best performance in predicting MVI, while also assessing prognostic risk.Evidence Level3Technical EfficacyStage 2
Restoration of sleep–wake behavior following short photoperiod exposure in ventral subicular lesioned male Wistar rats: A 24‐h sleep–wake electroencephalographical study
Authors: Prem Neethi , Sasidharan Arun , Srikumar Bettadapura N. , Rao Byrathnahalli S. Shankaranarayana , Kutty Bindu M. 
Published: July 2024

AbstractThe ventral subiculum regulates emotion, stress responses, and spatial and social cognition. In our previous studies, we have demonstrated anxiety‐ and depression‐like symptoms, deficits in spatial and social cognition in ventral subicular lesioned (VSL) rats, and restoration of affective and cognitive behaviors following photoperiod manipulation (short photoperiod regime, SPR; 6:18 LD cycle). In the present study, we have studied the impact of VSL on sleep–wake behavioral patterns and the effect of SPR on sleep–wakefulness behavior. Adult male Wistar rats subjected to VSL demonstrated decreased wake duration and enhanced total sleep time due to increased non‐rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS). Power spectral analysis indicated increased delta activity during NREMS and decreased sigma band power during all vigilance states. Light is one of the strongest entrainers of the circadian rhythm, and its manipulation may have various physiological and functional consequences. We investigated the effect of 21‐day exposure to SPR on sleep–wakefulness (S–W) behavior in VSL rats. We observed that SPR exposure restored S–W behavior in VSL rats, resulting in an increase in wake duration and a significant increase in theta power during wake and REMS. This study highlights the crucial role of the ventral subiculum in maintaining normal sleep–wakefulness patterns and highlights the effectiveness of photoperiod manipulation as a non‐pharmacological treatment for reversing sleep disturbances reported in mood and neuropsychiatric disorders like Alzheimer's disease, bipolar disorder, and major depressive disorder, which also involve alterations in circadian rhythm.