bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid‐term outcome of endoscopic sphincterotomy combined with large balloon dilation
Authors: Itokawa Fumihide , Itoi Takao , Sofuni Atsushi , Kurihara Toshio , Tsuchiya Takayoshi , Ishii Kentaro , Tsuji Shujiro , Ikeuchi Nobuhito , Umeda Junko , Tanaka Reina , Tonozuka Ryosuke , Honjyo Mitsuyoshi , Moriyasu Fuminori , Kasuya Kazuhiko , Tsuchida Akihiko 
Published: July 2014

AbstractBackground and AimEndoscopic sphincterotomy (ES) combined with large balloon dilation (ESLBD) can be useful for extracting large and multiple bile duct stones. Although there are many studies on the feasibility and short‐term outcome, there are few reports about mid‐ to long‐term outcome after ESLBD. The aim of our study is to prospectively evaluate the mid‐term outcome of ESLBD.MethodsOne hundred eighty‐three patients who underwent ESLBD between November 2006 and May 2012 were included. The patients were followed up periodically after the procedure until April 2013. Papillary dilation was performed at the time of initial ES or prior ES. Early and late adverse events and stone recurrence were evaluated in this study.ResultsThe patients' mean age was 76.6 ± 10.7 years. Surgically altered anatomy was present: Billroth I gastrectomy (2), Billroth II gastrectomy (13), and gastrectomy with Roux‐en Y reconstruction (18). Seventy‐eight (42.6%) patients had periampullary diverticulum. Prior ES had been performed in 40 (21.9%) patients. The mean follow‐up period was 43.5 ± 19.7 months (range 11–78). Eight (4.4%) patients had stone recurrence. There was rare stone recurrence after initial ESLBD treatment and native gastrointestinal anatomy. Univariate and multivariate analyses showed that prior ES and previous history of stone recurrence were predictive of stone recurrence (P < 0.001).ConclusionAt mid‐term outcome, ESLBD is associated with a low rate of recurrent bile duct stones, although long‐term follow up is needed.
Interspecies comparison of stellate cell‐containing macula flavae and vitaminAstorage in vocal fold mucosa
Authors: Toya Yutaka , Riabroy Napaporn , Davis Christopher R. , Kishimoto Yo , Tanumihardjo Sherry A. , Bless Diane M. , Welham Nathan V. 
Published: July 2014

AbstractThe macula flavae (MF), populated by vitaminA‐storing stellate cells (SCs), are believed to play a fundamental role in development, maintenance and repair of the vocal fold (VF) mucosa; however, to date, they have mostly been examined in observational human cadaver studies. Here, we conducted an interspecies comparison of MF and SC phenotype, as well as vitaminAquantification and localization, in human, pig, dog, rabbit and rat VF mucosae. MF containing vitaminA‐positive SCs were only identified in human and rat specimens. Pig, dog and rabbitVFmucosae contained no discernable MF, but rather exhibited preferential vitaminAlocalization to mucous (pig), serous (dog) or mixed (rabbit) glands. This glandular vitaminAstorage corresponded to exceedingly high concentrations of retinol in pig and dog mucosae, and retinyl ester in dog mucosa. These findings have significant implications for the presumed role of the MF and SCs in VF biology, the nature of vitaminAstorage within the VF mucosa, and the selection of an appropriate animal model for future experimental studies.
Change in affective well‐being on change in perceived job characteristics: The mediating role of hope
Authors: Reis Dorota , Hoppe Annekatrin 
Published: July 2014

Research on occupational health has consistently shown that job characteristics and personal resources predict employee well‐being. Building on the associative network theory, we claim that – vice versa – well‐being is likely to affect the perception of job characteristics and personal resources. The aim of this study was to expand the literature on job characteristics, personal resources, and employee well‐being (1) by taking a reversed causation perspective and (2) by investigating the dynamic nature of these relations in a latent change model. More specifically, we hypothesized that baseline levels and change in affective well‐being are related to change in emotional demands and autonomy, two core job characteristics for our sample of psychotherapists. In addition, we explored the mediating role of hope as a personal resource in this process. A total of 326 psychotherapists participated in a two‐wave online survey with a 5‐month time lag. Results revealed that baseline levels of and change in affective well‐being were associated with change in emotional demands. Furthermore, change in hope mediated the effect of change in affective well‐being on change in autonomy. In conclusion, the results show that affective well‐being can mark a starting point for building personal resources and changing employees' perceptions of their job characteristics.Practitioner points

Employees with high levels of affective well‐being perceive fewer emotional demands at work over time.

An increase in affective well‐being over a period of 5 months further decreases their experience of emotional demands at work.

Employees whose affective well‐being increases over time build hope at work. This, in turn, goes along with a more positive perception of their autonomy at work.
Prevalence and Predicting Factors for Commonly Neglected Sexual Side Effects to Radical Prostatectomies: Results from a Cross-Sectional Questionnaire-Based Study
Authors: Frey Anders , Sønksen Jens , Jakobsen Henrik , Fode Mikkel 
Published: July 2014

Abstract

Introduction
Altered perception of orgasm, orgasm-associated pain, penile sensory changes, urinary incontinence (UI) during sexual activity, penile shortening (PS), and penile deformity following radical prostatectomy (RP) have received increasing attention from researchers.

Aim
The aim of this study is to describe the prevalence and predictors of the above-mentioned side effects.

Methods
This was a cross-sectional questionnaire-based study among men who had undergone RP between 3 and 36 months prior to study inclusion. Predicting factors were identified through logistic regression analyses.

Main Outcome Measures
The primary outcome measures were prevalence rates of the above-mentioned side effects.

Results
Overall, 316 questionnaires were available for analyses. Of the sexually active patients (n = 256), 12 (5%) reported anorgasmia, whereas 153 (60%) reported decreased orgasm intensity. Delayed orgasms were reported by 146 (57%). Twenty-three patients (10%) had experienced pain during orgasm. UI during sexual activity were reported by 99 patients (38%). Out of the whole population, 77 patients (25%) reported sensory changes in the penis. A total of 143 patients (47%) reported a subjective loss of penile length of &gt;1 cm. An altered curvature of the penis was reported by 30 patients (10%). Patients had increasing risk of UI during sexual activity (odds ratio [OR] 1.17; 95% confidence interval [CI] 1.10–1.25) and orgasmic dysfunction (OR 1.09; 95% CI 1.01–1.16) with increasing International Consultation on Incontinence Questionnaire scores. Erectile dysfunction (OR 1.81; 95% CI 1.07–3.10) and a high body mass index (OR 1.10; 95% CI 1.02–1.19) increased the risk of PS after RP. Nerve-sparing (OR 0.32; 95% CI 0.16–0.95) reduced the risk of PS.

Conclusions
Orgasm-associated problems, UI during sexual activity, penile sensory changes, PS, and penile deformity are common side effects to RP. Daytime UI, erectile dysfunction, and nerve-sparing status can help identify patients at risk.
Association of PCOS and Its Clinical Signs with Sexual Function among Iranian Women Affected by PCOS
Authors: Hashemi Somayeh , Ramezani Tehrani Fahimeh , Farahmand Maryam , Bahri Khomami Mahnaz 
Published: July 2014

Abstract

Introduction
Polycystic ovary syndrome (PCOS) and its physiological and psychological changes influence the sexual function of women affected.

Aim
In the present study, we aimed to investigate the association of PCOS and its clinical signs with sexual function among a population of married Iranian women affected by PCOS.

Main Outcome Measure
The impact of clinical signs of PCOS on sexual function of affected women was the main outcome measure in the present study.

Methods
This cross-sectional study was carried out on 591 married women with PCOS, aged 18–45 years. Data were collected using a questionnaire including information on demographic and reproductive status and the Female Sexual Function Index. Data were analyzed using chi-square test, Mann–Whitney test, and logistic regression analysis.

Results
The participants' mean age was 30.6 years. Among associated manifestations of PCOS, infertility and hair loss have significant adverse effects on female sexual function. Logistic regression analysis showed that PCOS women with infertility have a significantly lower sexual function score compared with those who are fertile. Subgroup analysis demonstrated that compared with their fertile counterparts, PCOS women with infertility had significant sexual dysfunction in all aspects except desire and pain.

Conclusion
Among various manifestations of PCOS, infertility mainly disrupts the sexual function of affected women.
Possibility of the Production of Functional Low‐Fat Food Spread of Hull‐Less Pumpkin Seed Flour from Rheological and Textural Aspect
Authors: Nikolić Ivana , Dokić Ljubica , Krstonošić Veljko , Šereš Zita , Šoronja–Simović Dragana 
Published: July 2014

AbstractA new kind of functional low‐fat spread with hull‐less pumpkin seed flour and fat replacer, in gel form, was defined in this work from a rheological and textural aspect. Observed spreads were systems with thixotropic flow behavior. All determined rheological parameters, except of yield stress, were affected by gel concentration and amount of gel. Increase in gel concentration caused increase in consistency of the spreads, their possibility to recover and contribution of elastic components in the structure of the spread. Increase in the amount of gel influenced the balancing factor and reduced influence in gel concentration. Statistically, this was confirmed as interaction of observed factors (P < 0.05). Textural parameters confirmed that more gel provided softer consistency and increased the spreadability that could be optimized by concentration of applied gel. Optimal observed properties exhibited the spreads with low concentrated gel ranging from 0.5 to 1% and with a 70% gel amount.Practical ApplicationsA press cake is the by‐product of the mechanical process of oil extraction from pumpkin seeds. Hull‐less pumpkin seed cakes are chemically and nutritionally valuable because of its high quantity of crude protein, fatty acids, minerals and energy. It is a very low‐cost by‐product. The exploitation of hull‐less pumpkin seed cakes is poor, usually as animal feed. Possibilities of its application as a new low‐cost biosorbent, for enzymatic protein isolation or as flour‐like supplements are published. A number of low‐fat spreads based on nuts, seeds and fat replacers are covered by published articles or patents. Oil seed cakes are an alternative to manufacturing low‐fat spreads in terms of cost‐effectiveness as well as for increased protein content. The presented results demonstrate the possibility of producing low‐fat functional spread based on hull‐less pumpkin seed flour, and a new form of utilization of this raw material.
eGFR decrease during antiviral C therapy with first generation protease inhibitors: a clinical significance?
Authors: Loustaud‐Ratti Véronique , Rousseau Annick , Carrier Paul , Vong Chanlina , Chambaraud Tristan , Jacques Jérémie , Debette‐Gratien Marilyne , Sautereau Denis , Essig Marie 
Published: July 2014

AbstractBackground & AimsRenal toxicity of first generation protease inhibitors (PIs) was not a safety signal in phase III clinical trials, but was recently reported in recent studies. It appeared important to determine the clinical significance of these findings.MethodsWe retrospectively analysed 101 HCV patients receiving triple therapy with telaprevir (n = 36) or boceprevir (n = 26) or double therapy (n = 39) with peginterferon and ribavirin and having a close monitoring of eGFR (MDRD formula) during and after treatment. EGFR decline over time was assessed by a linear mixed‐effects model (LMEM) with search for possible explanatory covariates.ResultsPatients treated with telaprevir presented a significant decrease of eGFR with the same kinetics: initial decrease at W (week) 4, nadir at W8 (mean decrease 17.0 ± 18.9 ml/min/1.73 m2) and return to baseline at W16. The W8 eGFR was correlated with the D0 eGFR (R2 = 0.49). The LMEM showed that interindividual variability in the slope of eGFR vs time between D0 and W8 was non‐significant and eGFR nadir could be predicted from eGFR obtained at D0. In multivariate analysis, eGFR intercept (i.e. baseline value) was associated with older age and male sex.ConclusionThe eGFR significantly varied in telaprevir group only. Our model showed that eGFR nadir mainly depended on initial eGFR. As telaprevir has been shown to inhibit mostly the drug transporter OCT2 which interacts with creatinine transport, the early decrease of eGFR observed could be a benign phenomenon. However, as unpredictable true renal toxicity may occur during therapy, we recommend a thorough follow‐up of eGFR.
Increasing access to kidney transplantation in countries with limited resources: The Indian experience with Kidney Paired Donation
Authors: Kute Vivek B , Vanikar Aruna V , Shah Pankaj R , Gumber Manoj R , Patel Himanshu V , Engineer Divyesh P , Modi Pranjal R , Shah Veena R , Trivedi Hargovind L 
Published: July 2014

AbstractAccording to the Indian chronic kidney disease registry, in 2010 only 2% of end stage kidney disease patients were managed with kidney transplantation, 37% were managed with dialysis and 61% were treated conservatively without renal replacement therapy. In countries like India, where a well‐organized deceased donor kidney transplantation program is not available, living donor kidney transplantation is the major source of organs for kidney transplantation. The most common reason to decline a donor for directed living donation is ABO incompatibility, which eliminates up to one third of the potential living donor pool. Because access to transplantation with human leukocyte antigen (HLA)‐desensitization protocols and ABO incompatible transplantation is very limited due to high costs and increased risk of infections from more intense immunosuppression, kidney paired donation (KPD) promises hope to a growing number of end stage kidney disease patients. KPD is a rapidly growing and cost‐effective living donor kidney transplantation strategy for patients who are incompatible with their healthy, willing living donor. In principle, KPD is feasible for any centre that performs living donor kidney transplantation. In transplant centres with a large living donor kidney transplantation program KPD does not require extra infrastructure, decreases waiting time, avoids transplant tourism and prevents commercial trafficking. Although KPD is still underutilized in India, it has been performed more frequently in recent times. To substantially increase donor pool and transplant rates, transplant centres should work together towards a national KPD program and frame a uniform acceptable allocation policy.
Effects of endothelial nitric oxide synthase gene on end stage renal disease progression in autosomal dominant polycystic kidney disease
Authors: Xue Cheng , Zhou Chen‐chen , Sun Li‐jun , He Liang‐liang , Xu Cheng‐gang , Dai Bing , Mei Chang‐lin 
Published: July 2014

AbstractAimTo investigate whether endothelial nitric oxide synthase (eNOS) gene associate with the progression of autosomal dominant polycystic kidney disease (ADPKD).MethodsDatabases of EMBASE, Pubmed, ISI, Ovid Database, Cochrane library and China National Knowledge Infrastructure were all searched. Associated studies about eNOS polymorphisms and ADPKD were analyzed by meta‐analysis.ResultsA total of 11 studies with Glu298Asp and 4b/a polymorphisms were included. A allele of the 4b/a polymorphism increased the risk of end stage renal disease (ESRD) in ADPKD (odds ratio (OR) = 1.85, 95% confidence interval (CI) 1.17–2.94, P = 0.009). However, GG phenotype of Glu298Asp polymorphism neither decreased the ESRD risk (OR = 0.77, 95% CI 0.55–1.08, P = 0.13) nor affected the hypertension risk (OR = 1.04, 95% CI 0.66–1.66, P = 0.86). The GG phenotype carriers had later ESRD age compared with the T allele of Glu298Asp polymorphism (WMD = 2.39; 95% CI 1.32–3.46; P < 0.0001). Significant association was also found in Caucasians (WMD = 2.41; 95% CI 1.18–3.64; P = 0.0001). Subgroup analysis by gender indicated GG genotype carriers had older age of ESRD than T allele carriers in males (WMD = 4.51; 95% CI 3.95–5.08; P = 0.00001), but not in females.ConclusionsGG genotype of the Glu298Asp variant slowed the ESRD progression in ADPKD, while a allele carriers of the 4b/a variant increased the risk of ESRD. Variants of eNOS gene might play different roles in the ESRD progression in ADPKD.
Effects of a comprehensive cardiac rehabilitation program in patients with coronary heart disease in Korea
Authors: Kim So‐Sun , Lee Sunhee , Kim GiYon , Kang Seok‐Min , Ahn Jeong‐Ah 
Published: July 2014

AbstractThe purpose of this study was to develop a comprehensive cardiac rehabilitation program that considered patients' learning needs and cultural context, and to identify the impact of this program on patients with coronary heart disease in Korea. We employed a quasi‐experimental design to evaluate the effects of the developed program in 61 patients with coronary heart disease. The experimental group received education, counseling, educational materials, and telephone follow‐ups by cardiac nurses for six months. Results showed that participants of the program exhibited reduced body mass index and waist circumference as well as improved left ventricular diastolic function and cardiac disease‐related quality of life. There was no significant difference between the groups with the rate of recurring symptoms or cardiac events. This comprehensive cardiac rehabilitation program safely and effectively improved body composition, cardiac function, and quality of life in patients with coronary heart disease.
The oncogenic role of androgen receptors in promoting the growth of oral squamous cell carcinoma cells
Authors: Wu T‐F , Luo F‐J , Chang Y‐L , Huang C‐M , Chiu W‐J , Weng C‐F , Hsu Y‐K , Yuan T‐C 
Published: July 2014

ObjectivesThe aims of this study were to examine the expression of androgen receptors (AR) in oral squamous cell carcinoma (OSCC) cells and tumors and to determine the role of AR in regulating OSCC cell growth.Materials and MethodsFour OSCC cell lines were used for analyzing AR expression and transcriptional activity. The effects of AR knockdown on the growth and tumorigenicity of OSCC cells were examined. A series of 11 benign, 22 premalignant, and 21 malignant lesions of the oral cavity were used for analyzing AR expression.ResultsOSCC cells expressed AR proteins with differential activities. Stimulation of AR by dihydrotestosterone in OSCC cells caused an increase in cyclin D1 expression and promoted cell growth, whereas treatment with bicalutamide led to decreased cyclin D1 expression and inhibited cell growth. Knockdown of AR expression in OSCC cells resulted in decreased proliferation, increased apoptosis, and inhibited tumorigenicity. Results from immunohistochemical studies showed that AR immunoreactivity was found in 27% (3/11) of benign lesions, while 68% (15/22) of premalignant and 67% (14/21) of malignant lesions showed positive AR staining.ConclusionOur data suggest that OSCC cells express functional AR proteins which are critical for promoting cell growth and causing malignant disease.
Mesophyll conductance decreases in the wild type but not in an ABA‐deficient mutant (aba1) of Nicotiana plumbaginifolia under drought conditions
Authors: MIZOKAMI YUSUKE , NOGUCHI KO , KOJIMA MIKIKO , SAKAKIBARA HITOSHI , TERASHIMA ICHIRO 
Published: July 2014

AbstractUnder drought conditions, leaf photosynthesis is limited by the supply of CO2. Drought induces production of abscisic acid (ABA), and ABA decreases stomatal conductance (gs). Previous papers reported that the drought stress also causes the decrease in mesophyll conductance (gm). However, the relationships between ABA content and gm are unclear. We investigated the responses of gm to the leaf ABA content [(ABA)L] using an ABA‐deficient mutant, aba1, and the wild type (WT) of Nicotiana plumbaginifolia. We also measured leaf water potential (ΨL) because leaf hydraulics may be related to gm. Under drought conditions, gm decreased with the increase in (ABA)L in WT, whereas both (ABA)L and gm were unchanged by the drought treatment in aba1. Exogenously applied ABA decreased gm in both WT and aba1 in a dose‐dependent manner. ΨL in WT was decreased by the drought treatment to −0.7 MPa, whereas ΨL in aba1 was around −0.8 MPa even under the well‐watered conditions and unchanged by the drought treatment. From these results, we conclude that the increase in (ABA)L is crucial for the decrease in gm under drought conditions. We discuss possible relationships between the decrease in gm and changes in the leaf hydraulics.
Glycosyltransferase‐like protein ABI8/ELD1/KOB1 promotes Arabidopsis hypocotyl elongation through regulating cellulose biosynthesis
Authors: WANG XIN , JING YANJUN , ZHANG BAOCAI , ZHOU YIHUA , LIN RONGCHENG 
Published: July 2014

AbstractSeedling de‐etiolation (photomorphogenesis) is an important light‐regulated developmental process in plants. Here, we showed that disruption of the gene encoding a glycosyltransferase‐like protein, ABA INSENSITIVE 8 (ABI8)/ELONGATION EFFECTIVE 1 (ELD1)/KOBITO1 (KOB1), caused short‐hypocotyl elongation under all light conditions examined and even in darkness. We found that the ABI8 transcript level was down‐regulated by light in a phytochrome A‐dependent manner. Furthermore, light destabilized ABI8 protein via the 26S proteasome degradation pathway. We showed that ABI8 promoted the expression of genes involved in cell elongation and cellulose synthesis. Consistently, the cellulose content was reduced in the abi8 mutants and application of 2, 6‐dichlorobenzonitrile (an inhibitor of cellulose biosynthesis) mimicked the abi8 mutant phenotype. Moreover, we found that phytochrome and cryptochrome photoreceptors negatively, whereas CONSTITUTIVE PHOTOMORPHOGENIC 1 positively, regulated cellulose synthesis. We also showed that ELONGATED HYPOCOTYL 5 directly bound to the promoters of ABI8 and several cellulose synthesis genes and repressed their expression in light conditions. Taken together, our study reveals that ABI8 functions as a negative factor in light inhibition of hypocotyl elongation through modulating cellulose biosynthesis.