bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rehabilitation of an Auricular Defect using Spectacle Retained Silicone Ear Prosthesis and Ear Stent
Authors: Mohamed Kasim , Vaidyanathan Anandkumar , Mani Umamaheswari , Bhatia Yadharth , Veeravalli Padmanabhan Thallam 
Published: March 2013

ABSTRACT
Auricular defects resulting from skin cancer, trauma or congenital cause present reconstructive challenges. Surgical reconstruction may provide effective results for smaller and larger defects. However, some patients do not prefer surgical intervention for rehabilitation due to fear of pain. The use of silicone material for fabrication of facial prosthesis has made it possible to acceptably restore what has been lost. The application of skill and resources in the correct direction can provide the needy patients good treatment options that are cost-effective and esthetically acceptable. This article describes a simple clinical technique to rehabilitate patients with auricular defects. The purpose of this treatment was to minimize the extent of surgical intervention and to restore the lost facial structure to patient's satisfaction in a manner that was both cosmetically elegant and cost-effective.

How to cite this article
Mohamed K, Vaidyanathan A, Mani U, Bhatia Y, Veeravalli PT. Rehabilitation of an Auricular Defect using Spectacle Retained Silicone Ear Prosthesis and Ear Stent. Int J Prosthodont Restor Dent 2012;2(1):29-33.
Tumor-related Lipid Exudation and Associated Tumor-related Complications after Plaque Radiotherapy of Posterior Uveal Melanoma
Authors: Mashayekhi Arman , Tuncer Samuray , Shields Carol L. , Shields Jerry A. 
Published: March 2013

Purpose To identify complications associated with tumor-related lipid exudation (TRLE) after plaque radiotherapy of posterior uveal melanoma. Methods Comparative study including 294 patients with posterior uveal melanoma who developed TRLE after plaque radiotherapy (TRLE group) and 294 patients who did not develop TRLE (non-TRLE group). Patients in the TRLE group were matched with patients in the non-TRLE group for age, gender, and initial tumor thickness. Results The TRLE group was associated with significantly higher incidence of postradiation complications including early transient increase of serous retinal detachment (p<0.001), iris neovascularization (NVI) (p<0.001), neovascular glaucoma (NVG) (p<0.001), posterior synechia (p<0.001), vitreous hemorrhage (p<0.001), subretinal hemorrhage (p<0.001), and retinoschisis (p<0.001). A significant relationship was found between extent of TRLE and NVI (p<0.001), NVG (p<0.001), posterior synechia (p = 0.007), and retinoschisis over tumor (p = 0.010). Radiation-induced retinopathy, maculopathy, and papillopathy were not associated with presence or extent of TRLE. Tumor-related lipid exudation was also associated with worse final visual acuity (p = 0.011), higher rate of secondary enucleation (p<0.001), and lower rate of systemic metastasis (p = 0.006). Conclusions Tumor-related lipid exudation following plaque radiotherapy of posterior uveal melanoma is associated with major intraocular complications and portends poor prognosis for final visual acuity and eye retention. These findings provide evidence for the presence of 2 distinct pathogenic mechanisms, one radiation-induced and one tumor-related, in development of postradiation complications in eyes with posterior uveal melanoma.
Dry Eye in Graves’ Ophthalmopathy: Correlation with Corneal Hypoesthesia
Authors: Achtsidis Vasilis , Tentolouris Nicholas , Theodoropoulou Sofia , Panagiotidis Dimitris , Vaikoussis Emmanuel , Saldana Manuel , Gouws Pieter , Theodossiadis Panagiotis G. 
Published: March 2013

Purpose To evaluate dry eye disease and corneal sensitivity in patients with early and active Graves’ ophthalmopathy (GO). Methods A total of 52 eyes of 26 patients with early GO and 74 eyes of 37 age- and sex-matched controls were included in our study. Dry eye disease was assessed based on the criteria of the International Dry Eye Workshop. Diagnosis of early GO was based on the European Group on Graves’ Orbitopathy consensus statement. Clinical Activity Score (CAS) and Werner-NOSPECS Score were determined. Corneal sensitivity was assessed using a Cochet-Bonnet aesthesiometer. Results A total of 67.8% of patients with early GO and 13.5% of healthy controls had ocular surface dryness (p<0.001). The mean Schirmer test score was significantly lower in patients with early GO (12.88 ± 7.94 mm [right eyes] and 14.04 ± 9.00 mm [left eyes]) than in controls (18.08 ± 7.26 mm [right eyes] and 18.05 ± 7.50 mm [left eyes] [p<0.05]). The tear film break-up time was lower in patients by 5.46 seconds and 5.74 seconds in right and left eyes (p<0.001). We also found a significant reduction in corneal sensitivity in patients with early GO (4.16 ± 0.68 [right eyes] and 4.10 ± 0.89 [left eyes]) than in controls (4.70 ± 0.34 [right eyes] and 4.72 ± 0.34 [left eyes] [p<0.05]). The CAS correlated significantly with the Schirmer test (r = −0.60, p = 0.003). Conclusions Dry eye is common in early GO even in the absence of apparent exophthalmos and is associated with CAS and reduced corneal sensitivity.
Salvaged Failed Roof Rings and Antiprotrusion Cages: Surgical Options and Implant Survival
Authors: Tangsataporn Suksan , Abolghasemian Mansour , Kuzyk Paul R. , Backstein David J. , Safir Oleg A. , Gross Allan E. 
Published: March 2013

Introduction Failed acetabular reinforcement rings (ARR) (roof rings and antiprotrusion cages) may require another ARR reconstruction or another type of acetabular device with or without a bone graft. The purpose of this study was to propose surgical options for salvage of failed ARRs and to compare the failure rate of each surgical option. Materials and methods We reviewed 33 first ARRs (12 roof rings and 21 antiprotrusion cages) which were revised and converted to a new acetabular reconstruction. Operative reports, radiographs, and clinical data were evaluated. Minimum follow-up was 24 months (average 57 months; range 24-209 months). Results 33 failed first ARRs were converted to one of three types of acetabular reconstruction, Trabecular Metal (TM) cup in 14, cup-cage in 7 and a second ARR in 12. The TM cup group (TM cup and cup-cage) had a significantly longer survival than the second ARR group (P = 0.025) on log-rank analysis. Discussion Treatment of a failed first ARR by a TM cup and a cup-cage provides better results when compared to treatment by a second ARR. Restoration of bone stock is the main factor in determining whether a TM cup or cup-cage rather than another conventional ARR can be used.
Impact of Active Patient follow-up on Worst-case Implant Survival Analysis
Authors: Matharu Gulraj S. , McBryde Callum W. , Treacy Ronan B. , Pynsent William B. , Pynsent Paul B. 
Published: March 2013

Background Patients lost to follow-up pose problems when performing implant survival analysis. We are unaware of any report detailing how implant survival is affected by the sequential capture of patients. Aims To assess the logistics of long-term follow-up of patients undergoing Birmingham Hip Resurfacing (BHR), and to determine what impact this had on implant survival with time. Methods Between 1997 and 2006 data was prospectively collected on consecutive BHR's implanted by a single surgeon in patients under 50 years of age. Survival analysis was performed at monthly intervals during this study with all patients lost to follow-up at any point in time considered to have failed. Results There were 447 BHR's implanted in 393 patients. At study commencement cumulative 10-year survival was 42% (95% CI 36% to 48%) calculated on the confirmed knowledge of the outcome at that time of 275 BHR's, with the remaining 172 lost to follow-up and considered to have been revised. As patients were actively followed-up there was gradual improvement in survival and narrowing of confidence intervals with a final 10-year BHR survival of 96.3% (95% CI 93.7% to 98.3%) with no loss to follow-up. Conclusions The findings demonstrate improvement in long-term implant survival with the sequential capture of young and active patients undergoing BHR who were initially considered lost to follow-up. The results reiterate the recommendation that every effort should be made to follow all patients up after joint replacement. This will improve the accuracy of survival reporting and assist comparison between different prostheses.
Diurnal variations in water relations of deficit irrigated lemon trees during fruit growth period
Authors: García-Orellana Y. , Ortuño M. F. , Conejero W. , Ruiz-Sanchez M. C. 
Published: March 2013

Field-grown lemon trees (Citrus limon (L.) Burm. fil. cv. Fino) were subjected to different drip irrigation treatments: a control treatment, irrigated daily above crop water requirements in order to obtain non-limiting soil water conditions and two deficit irrigation treatments, reducing the water applied according to the maximum daily trunk shrinkage (MDS) signal intensity (actual MDS/control treatment MDS) threshold values of 1.25 (T1 treatment) and 1.35 (T2 treatment), which induced two different drought stress levels. Daily variations in leaf (Yleaf) and stem (Ystem) water potentials, leaf conductance, net photosynthesis, sap flow (SF) and trunk diameter fluctuations were studied on four occasions during the lemon fruit growth period. Ystem and Yleaf revealed a diurnal pattern in response to changes in evaporative demand of the atmosphere. Both water potentials decreased in response to water deficits, which were more pronounced in the T2 treatment. Ystem was seen to be a better plant water status indicator than Yleaf. The difference between the two values of Y (Ystem - Yleaf = DY) was closely correlated with sap flow, making it a suitable measure of leaf transpiration. Using the slope of this relationship, the canopy hydraulic conductance (KC) was estimated. When other continuously recorded plant-based indicators are not accessible, the concurrent measurement of leaf and stem water potentials at midday, which are relatively inexpensive to measure and user-friendly, act as sufficiently good indicators of the plant water status in field grown Fino lemon trees.
Isolation of table olive damage causes and bruise time evolution during fruit detachment with trunk shaker
Authors: Jimenez-Jimenez F. , Castro-Garcia S. , Blanco-Roldan G. L. , González-Sánchez E. J. , Gil-Ribes J. A. 
Published: March 2013

The high sensitivity of table olives to mechanical damage limits mechanical harvesting with trunk shakers. The objective of this study was the identification, evaluation and temporal evolution assessment of the sources of damage caused to the fruits. To do this, digital image analysis was used for the objective determination of damage produced to table olives. Harvesting tests were performed in an intensive olive orchard with trees of the ‘Manzanilla’ variety in Seville, Spain. Mechanical harvesting with trunk shakers and subsequent detachment of the fruits to the ground produced a level of bruise 12 times greater than the levels obtained from manual harvesting. Fruit-fruit and fruit-branch impacts and friction from the movement of the fruit in the tree canopy during vibration and detachment were the main causes of damage to the fruits. These causes represented a mean value of 60% of the damage produced to the fruits from mechanical harvesting. In addition, most bruising from mechanical damage occurred in the first hour after harvesting and followed an exponential tendency. The information obtained about table olive damage causes and bruise time evolution during fruit detachment with trunk shaker can be used by the producers to determine how to reduce and prevent bruising during harvesting operations.
La drogue et le journal de voyage contemporain
Authors: Banco Lindsey Michael 
Published: March 2013

Cet essai se penche sur les liens entre les représentations du voyage et les représentations des drogues dans les journaux de voyage contemporains. En tant que genre populaire non romanesque, le journal de voyage aide à structurer la perception du public à l’égard du voyage. Cependant, tout comme plusieurs autres formes d’écriture sur les voyages, il dépeint fréquemment les drogues. Nombre de journaux de voyage présentent des écrivains voyageant avec de la drogue, voyageant sous l’effet de la drogue, ou voyageant pour s’en procurer. Les journaux de voyage contemporains présentent souvent le voyage comme étant une métaphore paradigmatique, pourtant problématique, qui sert à comprendre divers genres d’expériences en lien avec la drogue : celles qui servent à acquérir des connaissances sur soi ou à subir des transformations, celles qui vont à la rencontre de l’altérité radicale ou cherchent à la domestiquer sous des formulations néocoloniales. Il est question dans ces pages de deux journaux de voyage relatant l’expérience des drogues, publiés à la fin du 20e siècle : Chasing the Dragon: Into the Heart of the Golden Triangle (1996) de Christopher Cox et Eating the Flowers of Paradise: A Journey Through the Drug Fields of Ethiopia and Yémen (1998) de Kevin Rushby. Mon analyse explore la façon avec laquelle ces récits populaires imaginent la connexion mobilité/intoxication et comment ces connexions font intervenir la double thématique de la mobilité planétaire et de la circulation et de la consommation illicites de substances psychotropes.
Jésus Christ à la rescousse de la dimension communautaire de la vie en Afrique
Authors: Ntabona Adrien 
Published: March 2013

Cet article tente d’élaborer une théologie africaine, en partant des développements johanniques sur la vie, pour relire la solidarité clanique africaine, ainsi que le penchant communautaire de la vie en Afrique noire. Dans la perspective de l’inculturation, il tâche de dynamiser ces valeurs africaines, de les dilater aux dimensions de la charité chrétienne ; ce faisant, le Christ occupe désormais le centre de la solidarité africaine et la fait tendre vers la communauté de vie qui existe entre le Père, le Fils et le Saint-Esprit.
The Human Kinome and Kinase Inhibition
Authors: Duong‐Ly Krisna C. , Peterson Jeffrey R. 
Published: March 2013

AbstractProtein and lipid kinases play key regulatory roles in a number of biological processes. Unsurprisingly, activating mutations in kinases have been linked to a number of disorders and diseases, most notably cancers. Thus, kinases have emerged as promising clinical targets. There are more than 500 human protein kinases and about 20 lipid kinases. Most protein kinases share a highly conserved domain, the eukaryotic protein kinase (ePK) domain, which contains the ATP and substrate‐binding sites. Many inhibitors in clinical use bind to the highly conserved ATP binding site. For this reason, many kinase inhibitors are not exclusively selective for their intended targets. Furthermore, despite the current interest in kinase inhibitors, very few kinases implicated in disease have validated inhibitors. This unit describes the human kinome, ePK structure, and types of kinase inhibitors, focusing on methods to identify potent and selective kinase inhibitors. Curr. Protoc. Pharmacol. 60:2.9.1‐2.9.14. © 2013 by John Wiley & Sons, Inc.
Patient‐Derived Models of Human Breast Cancer: Protocols for In Vitro and In Vivo Applications in Tumor Biology and Translational Medicine
Authors: DeRose Yoko S. , Gligorich Keith M. , Wang Guoying , Georgelas Ann , Bowman Paulette , Courdy Samir J. , Welm Alana L. , Welm Bryan E. 
Published: March 2013

AbstractResearch models that replicate the diverse genetic and molecular landscape of breast cancer are critical for developing the next‐generation therapeutic entities that can target specific cancer subtypes. Patient‐derived tumorgrafts, generated by transplanting primary human tumor samples into immune‐compromised mice, are a valuable method to model the clinical diversity of breast cancer in mice, and are a potential resource in personalized medicine. Primary tumorgrafts also enable in vivo testing of therapeutics and make possible the use of patient cancer tissue for in vitro screens. Described in this unit are a variety of protocols including tissue collection, biospecimen tracking, tissue processing, transplantation, and three‐dimensional culturing of xenografted tissue, which enable use of bona fide uncultured human tissue in designing and validating cancer therapies. Curr. Protoc. Pharmacol. 60:14.23.1‐14.23.43. © 2013 by John Wiley & Sons, Inc.
Differences Between Women and Men With Recent‐Onset Axial Spondyloarthritis: Results From a Prospective Multicenter French Cohort
Authors: Tournadre A. , Pereira B. , Lhoste A. , Dubost J. J. , Ristori J. M. , Claudepierre P. , Dougados M. , Soubrier M. 
Published: March 2013

ObjectiveTo clarify sex differences in early axial spondyloarthritis (SpA).MethodsIn total, 475 patients included in the Devenir des Spondylarthropathies Indifférenciées Récentes (Outcome of Recent Undifferentiated Spondylarthropathies) cohort, a prospective multicenter French cohort of patients with early inflammatory back pain suggestive of SpA, and fulfilling the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial SpA were studied. The clinical and imaging features were compared between sexes and according to the clinical or imaging arm of the ASAS criteria using univariate and multivariate analysis.ResultsComparisons between the 239 men and 236 women showed that women had higher disease activity when measured by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Patient Global Score and higher fatigue and functional scores despite having less radiographic sacroiliitis and magnetic resonance imaging (MRI) inflammation of sacroiliac joints and the spine than men. Disease activity measured by the C‐reactive protein (CRP)–based Ankylosing Spondylitis Disease Activity Score was not different between men and women. In contrast to patients classified with the clinical arm, disease activity and functional scores did not differ between women and men with sacroiliitis on imaging scans, except for fatigue and the Ankylosing Spondylitis Quality of Life questionnaire. Women with sacroiliitis had more peripheral involvement and more family history, whereas HLA–B27 positivity, elevated CRP, and MRI inflammation of the spine were associated with male sex.ConclusionWomen with early axial SpA according to the ASAS criteria had greater disease activity when measured by the BASDAI and worse functioning despite fewer radiologic abnormalities than men. The differences in disease expression may be confounding factors to establish the diagnosis of SpA and to assess disease activity in women, suggesting that the imaging arm is a pivotal measure in the ASAS criteria.
Robust adaptive unscented Kalman filter for attitude estimation of pico satellites
Authors: Hajiyev Chingiz , Soken Halil Ersin 
Published: March 2013

SUMMARYUnscented Kalman filter (UKF) is a filtering algorithm that gives sufficiently good estimation results for the estimation problems of nonlinear systems even when high nonlinearity is in question. However, in case of system uncertainty or measurement malfunctions, the UKF becomes inaccurate and diverges by time. This study introduces a fault‐tolerant attitude estimation algorithm for pico satellites. The algorithm uses a robust adaptive UKF, which performs correction for the process noise covariance (Q‐adaptation) or measurement noise covariance (R‐adaptation) depending on the type of the fault. By the use of a newly proposed adaptation scheme for the conventional UKF algorithm, the fault is detected and isolated, and the essential adaptation procedure is followed in accordance with the fault type. The proposed algorithm is tested as a part of the attitude estimation algorithm of a pico satellite. Copyright © 2013 John Wiley & Sons, Ltd.
Chemical Degradation in Organic Light‐Emitting Devices: Mechanisms and Implications for the Design of New Materials
Authors: Schmidbauer Susanna , Hohenleutner Andreas , König Burkhard 
Published: March 2013

AbstractDegradation of the materials in organic light‐emitting devices (OLEDs) is the major impediment for the development of economically feasible, highly efficient and durable devices for commercial applications. Even though this chemical degradation is complex and the least understood of the different degradation modes in OLEDs, scientists were successful in providing insight into some of the responsible processes. In this progress report we will review recent advances in the elucidation of chemical degradation mechanisms: First possible reasons for defect formation and the most common and important methods to investigate those processes are covered before discussing the reactions and their products for the different types of materials present in a device. We summarize commonalities in the occurring mechanisms, and identify structural features and moieties that can be detrimental to operational stability. Some of the resulting implications on the development of new materials are presented and backed by concrete examples from literature.
Fiber formation by dehydration‐induced aggregation of albumin
Authors: Wu Yonnie , Wang Kai , Buschle‐Diller Gisela , Liles Mark R. 
Published: March 2013

AbstractMany proteins are capable of forming fibrils in vitro, suggesting that the propensity for fiber formation is a generic property of polypeptides. Pathways leading to fibril assembly, however, still remain elusive. In this research, dehydration of bovine serum albumin (BSA) solutions was found to result in spontaneous and organized formation of densely packed fibrils with the majority of proteins converted to parallel β‐sheets. BSA aggregation was investigated in regard to drying conditions (airflow, temperature, and humidity) and the influence of pH, presence of anions, and protein concentration. Aggregates were prepared at large scale and crosslinked to produce water‐insoluble fibers with mechanical properties comparable to those of silk. Interactions between BSA and salts suggest that removing the inner water shell surrounding globular proteins leads to protein unfolding and aggregation at the water/air interface. BSA fibers can be formed into larger assemblies such as yarns, and dyed with acid dyes, thus showing great potential for future industrial‐scale applications. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
UV crosslinking of Fe3+‐doped poly(vinyl alcohol)—Characterization of optical properties and swelling behavior
Authors: Schauberger Jörg Guido , Riess Gisbert , Kern Wolfgang 
Published: March 2013

AbstractThe effects of UV irradiation on iron(III)chloride doped poly(vinyl alcohol) (PVA) films, using a high molar mass polymer, have been studied. It has been found that the polymer is oxidized and crosslinked during UV irradiation. UV/VIS spectra reveal an exponential loss of absorption at λ = 360 nm, and the refractive index of the PVA:FeCl3 films decreases significantly during UV irradiation (ΔnD = −0.09). The effects of crosslinking have been studied using the sol–gel technique, which revealed high gel contents due to doping and UV‐exposure. Photolithographic patterning of doped PVA films using a medium‐pressure mercury‐vapor UV source has been carried out, leading to good contrast behavior before and after development in aqueous media. A photobleaching effect was observed, therefore the curing of thicker films is feasible. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013