bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a ferromagnetic component in the superconducting state of Fe-excess Fe1.12Te1-xSex by electronic charge redistribution
Authors: Li Wen-Hsien , Karna Sunil K. , Hsu Han , Li Chi-Yen , Lee Chi-Hung , Sankar Raman , Cheng Chou Fang 
Published: June 2015

AbstractThe general picture established so far for the links between superconductivity and magnetic ordering in iron chalcogenide Fe1+y(Te1-xSex) is that the substitution of Se for Te directly drives the system from the antiferromagnetic end into the superconducting regime. Here, we report on the observation of a ferromagnetic component that developed together with the superconducting transition in Fe-excess Fe1.12Te1-xSex crystals using neutron and x-ray diffractions, resistivity, magnetic susceptibility and magnetization measurements. The superconducting transition is accompanied by a negative thermal expansion of the crystalline unit cell and an electronic charge redistribution, where a small portion of the electronic charge flows from around the Fe sites toward the Te/Se sites. First-principles calculations show consistent results, revealing that the excess Fe ions play a more significant role in affecting the magnetic property in the superconducting state than in the normal state and the occurrence of an electronic charge redistribution through the superconducting transition.
Dispersionless Manipulation of Reflected Acoustic Wavefront by Subwavelength Corrugated Surface
Authors: Zhu Yi-Fan , Zou Xin-Ye , Li Rui-Qi , Jiang Xue , Tu Juan , Liang Bin , Cheng Jian-Chun 
Published: June 2015

AbstractFree controls of optic/acoustic waves for bending, focusing or steering the energy of wavefronts are highly desirable in many practical scenarios. However, the dispersive nature of the existing metamaterials/metasurfaces for wavefront manipulation necessarily results in limited bandwidth. Here, we propose the concept of dispersionless wavefront manipulation and report a theoretical, numerical and experimental work on the design of a reflective surface capable of controlling the acoustic wavefront arbitrarily without bandwidth limitation. Analytical analysis predicts the possibility to completely eliminate the frequency dependence with a specific gradient surface which can be implemented by designing a subwavelength corrugated surface. Experimental and numerical results, well consistent with the theoretical predictions, have validated the proposed scheme by demonstrating a distinct phenomenon of extraordinary acoustic reflection within an ultra-broad band. For acquiring a deeper insight into the underlying physics, a simple physical model is developed which helps to interpret this extraordinary phenomenon and predict the upper cutoff frequency precisely. Generations of planar focusing and non-diffractive beam have also been exemplified. With the dispersionless wave-steering capability and deep discrete resolution, our designed structure may open new avenue to fully steer classical waves and offer design possibilities for broadband optical/acoustical devices.
The evolution and devolution of cognitive control: The costs of deliberation in a competitive world
Authors: Tomlin Damon , Rand David G. , Ludvig Elliot A. , Cohen Jonathan D. 
Published: June 2015

AbstractDual-system theories of human cognition, under which fast automatic processes can complement or compete with slower deliberative processes, have not typically been incorporated into larger scale population models used in evolutionary biology, macroeconomics, or sociology. However, doing so may reveal important phenomena at the population level. Here, we introduce a novel model of the evolution of dual-system agents using a resource-consumption paradigm. By simulating agents with the capacity for both automatic and controlled processing, we illustrate how controlled processing may not always be selected over rigid, but rapid, automatic processing. Furthermore, even when controlled processing is advantageous, frequency-dependent effects may exist whereby the spread of control within the population undermines this advantage. As a result, the level of controlled processing in the population can oscillate persistently, or even go extinct in the long run. Our model illustrates how dual-system psychology can be incorporated into population-level evolutionary models and how such a framework can be used to examine the dynamics of interaction between automatic and controlled processing that transpire over an evolutionary time scale.
First Principles Prediction of Topological Phases in Thin Films of Pyrochlore Iridates
Authors: Hu Xiang , Zhong Zhicheng , Fiete Gregory A. 
Published: June 2015

AbstractWhile the theoretical and experimental study of topological phases of matter has experienced rapid growth over the last few years, there remain a relatively small number of material classes that have been experimentally shown to host these phases. Most of these materials contain bismuth and none so far are oxides. In this work we make materials-specific predictions for topological phases using density functional theory combined with Hartree-Fock theory that includes the full orbital structure of the relevant iridium d-orbitals and the strong but finite spin-orbit coupling strength. We find Y2Ir2O7 bilayer and trilayer films grown along the [111] direction can support topological metallic phases with a direct gap of up to 0.05 eV, which could potentially bring transition metal oxides to the fore as a new class of topological materials with potential applications in oxide electronics.
Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence
Authors: Chu Jin , Li Jian-Guo , Hoffman Nicholas E. , Stough Alexandra M. , Madesh Muniswamy , Praticò Domenico 
Published: June 2015

AbstractThe formation of Aβ is directly controlled by the γ-secretase complex and its activator, γ-secretase activating protein (GSAP). GSAP derives from a C-terminal fragment of a larger precursor protein via a caspase-3 mediated cleavage. However, the mechanism regulating this process remains unknown. Here we provide in vitro experimental evidence that 5-Lipoxygenase (5LO) is as an endogenous regulator for GSAP formation, but not for other known γ-secretase modulators, by directly and specifically activating caspase-3. These results were confirmed in vivo by using transgenic mouse models of Alzheimer’s disease in which 5LO level and activity were modulated genetically or pharmacologically. Taken together, our findings demonstrate that GSAP cleavage via caspase-3 is regulated and depend upon the availability of 5LO further establishing this protein as an attractive and viable therapeutic target for Alzheimer’s disease.
Substrate-anchored and degradation-sensitive anti-inflammatory coatings for implant materials
Authors: Wu Duo , Chen Xingyu , Chen Tianchan , Ding Chunmei , Wu Wei , Li Jianshu 
Published: June 2015

AbstractImplant materials need to be highly biocompatible to avoid inflammation in clinical practice. Although biodegradable polymeric implants can eliminate the need for a second surgical intervention to remove the implant materials, they may produce acidic degradation products in vivo and cause non-bacterial inflammation. Here we show the strategy of “substrate-anchored and degradation-sensitive coatings” for biodegradable implants. Using poly(lactic acid)/hydroxyapatite as an implant material model, we constructed a layer-by-layer coating using pH-sensitive star polymers and dendrimers loaded with an anti-inflammatory drug, which was immobilised through a hydroxyapatite-anchored layer. The multifunctional coating can effectively suppress the local inflammation caused by the degradation of implant materials for at least 8 weeks in vivo. Moreover, the substrate-anchored coating is able to modulate the degradation of the substrate in a more homogeneous manner. The “substrate-anchored and degradation-sensitive coating” strategy therefore exhibits potential for the design of various self-anti-inflammatory biodegradable implant materials.
Exploring the open-circuit voltage of organic solar cells under low temperature
Authors: Qi Boyuan , Zhou Qing , Wang Jizheng 
Published: June 2015

AbstractOpen-circuit voltage (VOC) in organic solar cells (OSCs) is currently still not well-understood. A generally acceptable view is that VOC is mainly determined by the energy level offset between donor and acceptor materials. Recently in ternary blend OSCs, VOC is found to be dependent on the blend composition. But contrary to expectation, this dependence is not a simple linear relationship, which adds complications to understanding on VOC. Here, in order to figure out the origin of VOC, we performed a series of experiments on both binary and ternary blend OSCs in a wide temperature range from 15 K to 300 K. It is observed that the devices behave like Schottky barrier (SB) diode. By fitting the experimental results with SB diode model, the detailed device parameters of ternary blend OSCs are extracted and it is found that VOC is determined by the energetics of organic molecules and metal at the cathode interface and the inhomogeneity of the SB also play a great role in the origin of VOC at low temperatures. This work not only paves the way to deep understanding on the origin of VOC, but also opens a door to further exploring the general working principle of OSCs.
Radiation quality-dependence of bystander effect in unirradiated fibroblasts is associated with TGF-β1-Smad2 pathway and miR-21 in irradiated keratinocytes
Authors: Yin Xiaoming , Tian Wenqian , Wang Longxiao , Wang Jingdong , Zhang Shuyu , Cao Jianping , Yang Hongying 
Published: June 2015

AbstractTraditional radiation biology states that radiation causes damage only in cells traversed by ionizing radiation. But radiation-induced bystander effect (RIBE), which refers to the biological responses in unirradiated cells when the neighboring cells are exposed to radiation, challenged this old dogma and has become a new paradigm of this field. By nature, RIBEs are the consequences of intercellular communication between irradiated and unirradiated cells. However, there are still some important questions remain unanswered such as whether RIBE is dependent on radiation quality, what are the determining factors if so, etc. Using a transwell co-culture system, we found that HaCaT keratinocytes irradiated with α-particles but not X-rays could induce bystander micronucleus formation in unirradiated WS1 fibroblasts after co-culture. More importantly, the activation of TGF-β1-Smad2 pathway and the consistent decrease of miR-21 level in α-irradiated HaCaT cells were essential to the micronucleus induction in bystander WS1 cells. On the other hand, X-irradiation did not induce bystander effect in unirradiated WS1 cells, accompanied by lack of Smad2 activation and consistent decrease of miR-21 in X-irradiated HaCaT cells. Taken together, these results suggest that the radiation quality-dependence of bystander effect may be associated with the TGF-β1-Smad2 pathway and miR-21 in irradiated cells.
An integrated database of wood-formation related genes in plants
Authors: Xu Ting , Ma Tao , Hu Quanjun , Liu Jianquan 
Published: June 2015

AbstractWood, which consists mainly of plant cell walls, is an extremely important resource in daily lives. Genes whose products participate in the processes of cell wall and wood formation are therefore major subjects of plant science research. The Wood-Formation Related Genes database (WFRGdb, http://me.lzu.edu.cn/woodformation/) serves as a data resource center for genes involved in wood formation. To create this database, we collected plant genome data published in other online databases and predicted all cell wall and wood formation related genes using BLAST and HMMER. To date, 47 gene families and 33 transcription factors from 57 genomes (28 herbaceous, 22 woody and 7 non-vascular plants) have been covered and more than 122,000 genes have been checked and recorded. To provide easy access to these data, we have developed several search methods, which make it easy to download targeted genes or groups of genes free of charge in FASTA format. Sequence and phylogenetic analyses are also available online. WFRGdb brings together cell wall and wood formation related genes from all available plant genomes and provides an integrative platform for gene inquiry, downloading and analysis. This database will therefore be extremely useful for those who focuses on cell wall and wood research.
A pathway of nanocrystallite fabrication by photo-assisted growth in pure water
Authors: Jeem Melbert , bin Julaihi Muhammad Rafiq Mirza , Ishioka Junya , Yatsu Shigeo , Okamoto Kazumasa , Shibayama Tamaki , Iwasaki Tomio , Kato Takahiko , Watanabe Seiichi 
Published: June 2015

AbstractWe report a new production pathway for a variety of metal oxide nanocrystallites via submerged illumination in water: submerged photosynthesis of crystallites (SPSC). Similar to the growth of green plants by photosynthesis, nanocrystallites shaped as nanoflowers and nanorods are hereby shown to grow at the protruded surfaces via illumination in pure, neutral water. The process is photocatalytic, accompanied with hydroxyl radical generation via water splitting; hydrogen gas is generated in some cases, which indicates potential for application in green technologies. Together with the aid of ab initio calculation, it turns out that the nanobumped surface, as well as aqueous ambience and illumination are essential for the SPSC method. Therefore, SPSC is a surfactant-free, low-temperature technique for metal oxide nanocrystallites fabrication.
Mitochondria-focused gene expression profile reveals common pathways and CPT1B dysregulation in both rodent stress model and human subjects with PTSD
Authors: Zhang L , Li H , Hu X , Benedek D M , Fullerton C S , Forsten R D , Naifeh J A , Li X , Wu H , Benevides K N , Le T , Smerin S , Russell D W , Ursano R J 
Published: June 2015

AbstractPosttraumatic stress disorder (PTSD), a trauma-related mental disorder, is associated with mitochondrial dysfunction in the brain. However, the biologic approach to identifying the mitochondria-focused genes underlying the pathogenesis of PTSD is still in its infancy. Previous research, using a human mitochondria-focused cDNA microarray (hMitChip3) found dysregulated mitochondria-focused genes present in postmortem brains of PTSD patients, indicating that those genes might be PTSD-related biomarkers. To further test this idea, this research examines profiles of mitochondria-focused gene expression in the stressed-rodent model (inescapable tail shock in rats), which shows characteristics of PTSD-like behaviors and also in the blood of subjects with PTSD. This study found that 34 mitochondria-focused genes being upregulated in stressed-rat amygdala. Ten common pathways, including fatty acid metabolism and peroxisome proliferator-activated receptors (PPAR) pathways were dysregulated in the amygdala of the stressed rats. Carnitine palmitoyltransferase 1B (CPT1B), an enzyme in the fatty acid metabolism and PPAR pathways, was significantly over-expressed in the amygdala (P<0.007) and in the blood (P<0.01) of stressed rats compared with non-stressed controls. In human subjects with (n=28) or without PTSD (n=31), significant over-expression of CPT1B in PTSD was also observed in the two common dysregulated pathways: fatty acid metabolism (P=0.0027, false discovery rate (FDR)=0.043) and PPAR (P=0.006, FDR=0.08). Quantitative real-time polymerase chain reaction validated the microarray findings and the CPT1B result. These findings indicate that blood can be used as a specimen in the search for PTSD biomarkers in fatty acid metabolism and PPAR pathways, and, in addition, that CPT1B may contribute to the pathology of PTSD.
The positive effect on ketamine as a priming adjuvant in antidepressant treatment
Authors: Melo A , Kokras N , Dalla C , Ferreira C , Ventura-Silva A P , Sousa N , Pêgo J M 
Published: June 2015

AbstractKetamine is an anesthetic with antidepressant properties. The rapid and lasting effect of ketamine observed in preclinical and clinical research makes it a promising therapeutic to improve current major depression (MD) treatment. Our work intended to evaluate whether the combined use of classic antidepressants (imipramine or fluoxetine) and ketamine would improve the antidepressant response. Using an animal model of depressive-like behavior, we show that the addition of ketamine to antidepressants anticipates the behavioral response and accelerates the neuroplastic events when compared with the use of antidepressants alone. In conclusion, our results suggest the need for a reappraisal of the current pharmacological treatment of MD.
The Use of Bone Morphogenetic Protein in Pediatric Cervical Spine Fusion Surgery: Case Reports and Review of the Literature
Authors: Molinari Robert W. , Molinari Christine 
Published: June 2015

Study Design Case report. Objective There is a paucity of literature describing the use of bone graft substitutes to achieve fusion in the pediatric cervical spine. The outcomes and complications involving the off-label use of bone morphogenetic protein (BMP)-2 in the pediatric cervical spine are not clearly defined. The purpose of this article is to report successful fusion without complications in two pediatric patients who had instrumented occipitocervical fusion using low-dose BMP-2. Methods A retrospective review of the medical records was performed, and the patients were followed for 5 years. Two patients under 10 years of age with upper cervical instability were treated with occipitocervical instrumented fusion using rigid occipitocervical fixation techniques along with conventionally available low-dose BMP-2. A Medline and PubMed literature search was conducted using the terms “bone morphogenetic protein,” “BMP,” “rh-BMP2,” “bone graft substitutes,” and “pediatric cervical spine.” Results Solid occipitocervical fusion was achieved in both pediatric patients. There were no reported perioperative or follow-up complications. At 5-year follow-up, radiographs in both patients showed successful occipital cervical fusion without evidence of instrumentation failure or changes in the occipitocervical alignment. To date, there are few published reports on this topic. Complications and the appropriate dosage application in the pediatric posterior cervical spine remain unknown. Conclusions We describe two pediatric patients with upper cervical instability who achieved successful occipital cervical fusion without complication using off-label BMP-2. This report underscores the potential for BMP-2 to achieve successful arthrodesis of the posterior occipitocervical junction in pediatric patients. Use should be judicious as complications and long-term outcomes of pediatric BMP-2 use remain undefined in the existing literature.
Embedding ecosystem services in coastal planning leads to better outcomes for people and nature
Authors: Arkema Katie K. , Verutes Gregory M. , Wood Spencer A. , Clarke-Samuels Chantalle , Rosado Samir , Canto Maritza , Rosenthal Amy , Ruckelshaus Mary , Guannel Gregory , Toft Jodie , Faries Joe , Silver Jessica M. , Griffin Robert , Guerry Anne D. 
Published: June 2015

Significance
Oceans and coasts provide people with diverse benefits, from fisheries that sustain lives and livelihoods to recreational opportunities that generate tourism. However, translating appreciation of these benefits into changes in management and policy is not trivial. We report on a ground-breaking effort to use ecosystem-service values and models within a coastal planning process. By accounting for spatial variation in the influence of human activities on services, our results allowed stakeholders and policymakers to refine zones of human use, reduce risk to ecosystems, and enhance delivery of multiple ocean and coastal benefits. Application of our approaches and tools will enable planners worldwide to bring ecosystem-service science to bear on real-world decisions, thus directing actions that protect ecosystems and their benefits for people.
Impacts of conservation and human development policy across stakeholders and scales
Authors: Li Cong , Zheng Hua , Li Shuzhuo , Chen Xiaoshu , Li Jie , Zeng Weihong , Liang Yicheng , Polasky Stephen , Feldman Marcus W. , Ruckelshaus Mary , Ouyang Zhiyun , Daily Gretchen C. 
Published: June 2015

SignificanceUnderstanding costs and benefits to multiple stakeholders, and how they change through time, is essential to designing effective conservation and human development policies. Where, when, and to whom benefits are delivered are rarely analyzed, however. We examine one of China’s conservation–development policies—the Relocation and Settlement Program of Shaanxi Province (RSP)—drawing insights of broad relevance. Although the RSP benefits the municipal government, downstream water consumers, and global beneficiaries, the short-run costs to local households and the municipal government greatly exceed these benefits. Moreover, poor households are unable to pay the upfront costs and have difficulty participating. The RSP is well designed to reduce local ecological pressure and enhance human development, but its effectiveness could be strengthened in key ways.
Political influences on greenhouse gas emissions from US states
Authors: Dietz Thomas , Frank Kenneth A. , Whitley Cameron T. , Kelly Jennifer , Kelly Rachel 
Published: June 2015

Significance
Population and affluence have long been seen as major drivers of environmental stress. A substantial empirical literature now substantiates their role in anthropogenic environmental change. Using data on greenhouse gas emission from US states, we show that the effects of population and affluence can be substantially moderated by political factors and in particular support for environmentalism. Our results indicate the potential of politics to ameliorate the effects of the scale of economic activity on the environment and our methods provide a vehicle for testing the influence of diverse hypothesized human drivers of environmental change.
Parental care buffers against inbreeding depression in burying beetles
Authors: Pilakouta Natalie , Jamieson Seonaidh , Moorad Jacob A. , Smiseth Per T. 
Published: June 2015

Significance
When relatives mate, their inbred offspring often suffer a reduction in fitness-related traits known as “inbreeding depression.” Environmental stresses such as starvation and competition can exacerbate these fitness costs of inbreeding. However, caring parents could mitigate the fitness costs of inbreeding by neutralizing the effects of these environmental stresses. We tested the hypothesis that maternal care can buffer against inbreeding depression in the offspring in burying beetles. Indeed, the female's presence led to a higher increase in larval survival in inbred than in outbred broods, and it increased the lifespan of inbred but not outbred adults. Our findings suggest that parental care can moderate the severity of inbreeding depression, possibly affecting how parental care strategies and inbreeding avoidance mechanisms evolve.