bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanistic Understanding of the Divergent Cyclizations of o‐Alkynylbenzaldehyde Acetals and Thioacetals Catalyzed by Metal Halides
Authors: Mi Yanhua , Zhou Tao , Wang Kung‐Pern , Lee Daesung , Xia Yuanzhi 
Published: September 2015

AbstractThe mechanisms of regiodivergent cyclizations of o‐alkynylbenzaldehyde acetals and thioacetals catalyzed by Pd and Pt halides are studied. DFT calculations found that both reactions are initiated by electrophilic activation of the acetylenic moiety instead of the previously proposed metal‐triggered CX (X=O, S) cleavage. Both the regioselective cyclization of the π‐alkyne complex and the chemoselective [1,2]‐migration in the carbenoid intermediate were determined as key steps to achieving the observed divergence. For acetal derivatives containing an internal alkyne, the 6‐endo‐dig cyclization is more favorable and leads to the carbenoid intermediate easily through further steps of CX fragmentation and carbocation cyclization. Then, from the carbenoid intermediate, the [1,2]‐migration of sulfur is easier than that of H, Me, and Ph; whereas, a reversed aptitude was predicted for the oxygen analogue, which is consistent with the greater ability of sulfur atoms to stabilize β‐carbocations. However, for precursors containing a terminal alkyne, the 5‐exo‐dig pathway is preferred and only the 1,2‐disubstituted indene product is seen, irrespective of the nature of the acetal; thus, a different product from that reported in the literature is predicted for benzaldehyde acetal with a terminal alkyne at the ortho position. This prediction led us to reconsider some of the reported results and hidden realities were uncovered with solid new experimental evidence.
Ruthenium(II)‐Catalyzed CH Functionalizations with Allenes: Versatile Allenylations and Allylations
Authors: Nakanowatari Sachiyo , Ackermann Lutz 
Published: September 2015

AbstractRuthenium(II)‐catalyzed direct CH functionalization of aromatic compounds with allenes was achieved under exceedingly mild reaction conditions to yield trisubstituted allenes. The reactions of N‐methoxybenzamides proceeded smoothly in an isohypsic fashion at ambient temperature with high chemo‐ and regioselectivity, thereby providing a versatile means of accessing trisubstituted allenes. Detailed mechanistic studies were suggestive of a kinetically relevant CH metalation step, which occurs by the assistance of a carboxylate moiety; this also set the stage for unprecedented CH allylations with removable directing groups in a step‐economical fashion.
ChemInform Abstract: Structural and Electronic Investigations of PbTa4O11 and BiTa7O19 Constructed from α‐U3O8 Types of Layers.
Authors: Boltersdorf Jonathan , Maggard Paul A. 
Published: September 2015

AbstractPbTa4O11 (I) is prepared by flux‐mediated ion‐exchange by heating a 10:1 molar mixture of PbCl2 and Ag2Ta4O11 (evacuated silica tubes, 700 °C, 96 h) with the precursor Ag2Ta4O11 being prepared by solid state reaction of Ag2O and Ta2O5 (alumina crucible, 1000 °C, 24 h).
ChemInform Abstract: New Rhombohedral Pyrochlores Ca2Ln3Sb3O14 (Ln = Lanthanide and Y): Space Group Revised.
Authors: Fu W. T. , Ijdo D. J. W. 
Published: September 2015

AbstractThe structure of Ca2Ln3Sb3O14 (Ln: lanthanides, Y) is re‐examined by Rietveld refinements of either combined X‐ray and neutron diffraction or XRD data alone.
ChemInform Abstract: Al‐Doped Zinc Oxide Nanostructures as Transparent Conductive Window Layer for Photovoltaic Applications.
Authors: Mohite R. M. , Kothawale R. R. 
Published: September 2015

AbstractZnO:Al (5 wt.%) (AZO) nanorod thin films are deposited on glass plates from an aqueous solution of Zn(NO3)2, EDTA, en, and AlCl3 together with PEG as a morphology controlling surfactant (65 °C, 6 h) followed by staged annealing (200, 300, and 400 °C, 5 h each).
ChemInform Abstract: Phase Equilibria in BaB2O4—LiF System and β‐BaB2O4 Bulk Crystals Growth.
Authors: Simonova E. A. , Kokh A. E. , Kononova N. G. , Shevchenko V. S. , Kokh D. A. 
Published: September 2015

AbstractUsing BaCO3, H3BO3, and LiF as starting materials a phase diagram of the title system is established by solid state synthesis (Pt crucible, 700 °C, 3—5 d), differential thermal analysis, modified visual polythermal analysis, and XRD.
ChemInform Abstract: Organic—Inorganic Hybrid Materials Based on Basket‐Like {Ca@P6Mo18O73} Cages.
Authors: Zhang He , Yu Kai , Lv Jing‐hua , Gong Li‐hong , Wang Chun‐mei , Wang Chun‐xiao , Sun Di , Zhou Bai‐Bin 
Published: September 2015

AbstractCompounds (IV), (VI), (VII), and (VIII) are hydrothermally synthesized and their structures are determined by single crystal XRD.
ChemInform Abstract: RFe2MgxAl8‐x (R: La—Nd and Sm; x ≈ 0.8): Flux Synthesis, Structure, Magnetic and Electrical Properties.
Authors: Ma Xiaowei , Chai Ping , Chen Banghao , Lochner Eric , Latturner Susan E. 
Published: September 2015

AbstractSingle crystals of Mg‐substituted CeFe2Al8‐type intermetallics LnFe2MgxAl8‐x (Ln: La—Nd, Sm; x ≤ 1) are grown by reaction of Fe and Ln in a 1:1 Mg/Al reactive flux (steel capsules in evacuated silica tubes, 950 °C, 5 h; controlled cooling).
ChemInform Abstract: Noncentrosymmetric Rare‐Earth Copper Gallium Chalcogenides RE3CuGaCh7 (RE: La—Nd; Ch: S, Se): An Unexpected Combination.
Authors: Iyer Abishek K. , Rudyk Brent W. , Lin Xinsong , Singh Harpreet , Sharma Arzoo Z. , Wiebe Christopher R. , Mar Arthur 
Published: September 2015

AbstractLn3CuGaS7 and Ln3CuGaSe7 (Ln: La—Nd) are prepared by heating stoichiometric amounts of the elements (evacuated silica tubes, 1050 °C (sulfides)/900 °C (selenides), 5 d).
ChemInform Abstract: Mild Arylboronic Acid Catalyzed Selective [4 + 3] Cycloadditions: Access to Cyclohepta[b]benzofurans and Cyclohepta[b]indoles.
Authors: Cao Kou‐Sen , Bian Hong‐Xu , Zheng Wen‐Hua 
Published: September 2015

Abstract3,5‐Bis(trifluoromethyl)benzeneboronic acid proves to be an efficient catalyst for the cycloaddition of allylic cations with various dienes under mild reaction conditions.
ChemInform Abstract: Catalytic Intramolecular Aminofluorination, Oxyfluorination, and Carbofluorination with a Stable and Versatile Hypervalent Fluoroiodine Reagent.
Authors: Yuan Weiming , Szabo Kalman J. 
Published: September 2015

AbstractFor the first time, three types of fluorocyclization reactions are accomplished by using the same fluorination reagent (HFR).
ChemInform Abstract: Accessing Nitrosocarbonyl Compounds with Temporal and Spatial Control via the Photoredox Oxidation of N‐Substituted Hydroxylamines.
Authors: Frazier Charles P. , Palmer Leoni I. , Samoshin Andrey V. , Read de Alaniz Javier 
Published: September 2015

AbstractHighly reactive acylnitroso species are generated from hydroxamic acids (I) via photoredox catalysis.
ChemInform Abstract: Safe and Convenient Nitroxyl Radical and Imide Dual Catalyzed NaOCl Oxidation of Alcohols to Aldehydes/Ketones.
Authors: Fukuda Naohiro , Izumi Minoru , Ikemoto Tomomi 
Published: September 2015

AbstractA combination of cyanuric acid, NaOCl, K2CO3, and TEMPO or 2‐azaadamantane N‐oxyl is described as an efficient system for the oxidation of primary alcohols to carboxylic acids and secondary alcohols to ketones.
ChemInform Abstract: Enantioselective Fluorination of β‐Ketoesters Catalyzed by Complexes of New Mono‐Oxazoline Ligands.
Authors: Niu Teng , Han Xiping , Huang Danfeng , Wang Ke‐Hu , Su Yingpeng , Hu Yulai , Fu Ying 
Published: September 2015

AbstractA new kind of mono‐oxazoline ligand (OXP) is prepared and used as catalyst for the enantioselective fluorination of β‐ketoesters by NFSI.
ChemInform Abstract: Enantioselective 1,4‐Addition of Cyclopropylboronic Acid Catalyzed by Rhodium/Chiral Diene Complexes.
Authors: Takechi Ryosuke , Nishimura Takahiro 
Published: September 2015

AbstractRegioselective cyclopropylation of alkenylsulfones (I) and (IV), enones (VI), enoates (VIII) and nitroalkenes (X) proceeds in good to high yields and with high enantioselectivities.
ChemInform Abstract: Copper‐Free Arylation of 3,3‐Disubstituted Allylic Halides with Triazene‐Softened Aryl Grignard Reagents.
Authors: Xu Lijun , Liu Zhubo , Dong Weipeng , Song Jinyu , Miao Maozhong , Xu Jianfeng , Ren Hongjun 
Published: September 2015

AbstractThe α‐ vs.
ChemInform Abstract: Rhodium‐Catalyzed Hydroformylation of 1,1‐Disubstituted Allenes Employing the Self‐Assembling 6‐DPPon System.
Authors: Koepfer Alexander , Breit Bernhard 
Published: September 2015

AbstractDisubstituted 3‐butenals are formed (Z)‐selectively by hydroformylation of allenes in the presence of the rhodium catalyst.
ChemInform Abstract: One‐Pot Dehydrations Using Phenyl Isothiocyanate.
Authors: Majetich George , Irvin Thomas C. , Thompson Stephen B. 
Published: September 2015

AbstractAlcohols, e.g. (I), (III), (V) and (VII), undergo dehydration after conversion into the corresponding sodium carbonimidothioate salts followed by pyrolysis.
ChemInform Abstract: Synthesis of Thioacetal via AgOTf‐Catalyzed Reaction of 2‐Alkynylbenzaldehyde with Thiol.
Authors: Wu Ran , Gao Shang , Yang Guanghui , Pan Lingling , Liu Ming , Hu Keyong , Zhong Weihui , Yu Chuanming 
Published: September 2015

AbstractThe title reaction affords 2‐alkynylbenzaldehyde thioacetals (III) in good to excellent yields at room temperature in short reaction times.
ChemInform Abstract: Synthesis of α‐Trifluoroethoxy‐Substituted Ketones.
Authors: Wang Yuguang , You Yi , Weng Zhiqiang 
Published: September 2015

AbstractThe nucleophilic substitution of α‐haloketones with 2,2,2‐trifluoroethanol is readily accomplished in the presence of Cs2CO3 as the base to give α‐(2,2,2‐trifluoroethoxy)ketones under mild reaction conditions.
ChemInform Abstract: Difluoroallylation Using a 2‐Bromomethyl‐1,1‐difluoroalk‐1‐ene.
Authors: Mears Paul R. , Thomas Eric J. 
Published: September 2015

AbstractA variety of aromatic and aliphatic aldehydes are difluoroallylated by the title difluoroalkene (I) leading to fluorinated methylenealkanols (III) in good to excellent yields.
ChemInform Abstract: A Convenient Synthesis of Dialkyl 2‐(2‐Haloethylidene)malonates, Cyanoacetates and Halocrotonates by One Carbon Extension
Authors: Sathishkumar S. , Mahasampathgowri S. , Balasubramanian K. K. , Saiganesh R. 
Published: September 2015

Abstractusing dimethylsulfoxonium methylide
ChemInform Abstract: Ruthenium‐Catalyzed Rearrangement of Propargyl Sulfoxides: Formation of α,β‐Unsaturated Thioesters.
Authors: Zheng Renhua , Wang Youliang , Zhang Liming 
Published: September 2015

AbstractA Ru catalyzed transformation of propargyl sulfoxides (I) into synthetically useful α,β‐unsaturated thioesters (II) is developed.
ChemInform Abstract: Rhodium‐Catalyzed Addition—Spirocyclization of Arylboronic Esters Containing β‐Aryl α,β‐Unsaturated Ester Moiety.
Authors: Matsuda Takanori , Yasuoka Satoshi , Watanuki Shoichi , Fukuhara Keisuke 
Published: September 2015

AbstractSpirocyclic 1‐indanones are synthesized by rhodium‐catalyzed spirocyclization involving sequential transmetalation, intramolecular addition to a C=C bond, and β‐oxygen elimination.
ChemInform Abstract: Convenient N‐Acetylation of Amines in N,N‐Dimethylacetamide with N,N‐Carbonyldiimidazole.
Authors: Chikkulapalli Anil , Aavula Sanjeev Kumar , Rifahath Mona N. P. , Karthikeyan C. , Vinodh Kumar C. H. , Manjunatha Sulfur G. , Shanmugam Sumathi 
Published: September 2015

AbstractThe acetylation agent (I) also acts as solvent.
ChemInform Abstract: Ru(II)‐Catalyzed Site‐Selective Hydroxylation of Flavone and Chromone Derivatives: The Importance of the 5‐Hydroxyl Motif for the Inhibition of Aurora Kinases.
Authors: Kim Kiho , Choe Hyeonjeong , Jeong Yujeong , Lee Jun Hee , Hong Sungwoo 
Published: September 2015

AbstractThe title reaction allows a rapid and site‐selective installation of the hydroxyl group.
ChemInform Abstract: Enantioselective Synthesis of Tertiary Propargylic Alcohols under N‐Heterocyclic Carbene Catalysis.
Authors: Sanchez‐Diez Eduardo , Fernandez Maitane , Uria Uxue , Reyes Efraim , Carrillo Luisa , Vicario Jose L. 
Published: September 2015

AbstractAn enantioselective unprecedented NHC‐catalyzed benzoin reaction of aromatic and aliphatic aldehydes with alkyl alkynyl ketones including trifluoromethyl ketones is developed.
ChemInform Abstract: Selective Access to All Four Diastereomers of a 1,3‐Amino Alcohol by Combination of a Keto Reductase‐ and an Amine Transaminase‐Catalyzed Reaction.
Authors: Kohls Hannes , Anderson Mattias , Dickerhoff Jonathan , Weisz Klaus , Cordova Armando , Berglund Per , Brundiek Henrike , Bornscheuer Uwe T. , Hoehne Matthias 
Published: September 2015

AbstractThe synthetic pathway to obtain the (2R,4R)‐enantiomer (III) is outlined.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Arylation of C(sp3)—H Bonds of Aliphatic Amides: Controlling Enantioselectivity Using Chiral Phosphoric Amides/Acids.
Authors: Yan Shao‐Bai , Zhang Song , Duan Wei‐Liang 
Published: September 2015

AbstractAmong various chiral ligands tested, BPA is found to be the most efficient one.
ChemInform Abstract: [2,3]‐Sigmatropic Rearrangement of Propargylic Sulfinates by a Pale Cu1‐USY Zeolite and Copper Salts.
Authors: Hampton Carissa S. , Harmata Michael 
Published: September 2015

AbstractCopper ions are found to catalyze the [2,3]‐sigmatropic rearrangement of propargylic sulfinates (I), (III), and (V) to allenic sulfones (II), (IV), and (VI), respectively.
ChemInform Abstract: Organocatalyzed Benzannulation for the Construction of Diverse Anthraquinones and Tetracenediones.
Authors: Somai Magar Krishna Bahadur , Xia Likai , Lee Yong Rok 
Published: September 2015

AbstractThe reaction of α,β‐unsaturated aldehydes with quinone derivatives gives the annulated title compounds in high yields with remarkable regioselectivities.
ChemInform Abstract: AgNO2‐Mediated Cleavage of the N—N Bond of Sulfonylhydrazones and Oxygen Transfer: Access to Fulleroisoxazolines via Radical Cyclization with [60]Fullerene.
Authors: Liu Tong‐Xin , Ma Jinliang , Chao Di , Zhang Pengling , Liu Qingfeng , Shi Lei , Zhang Zhiguo , Zhang Guisheng 
Published: September 2015

AbstractAn unprecedented AgNO2‐mediated novel transformation of sulfonylhydrazones with [60]fullerene to various fulleroisoxazolines is presented.
ChemInform Abstract: Light‐Driven Nitrile Imine‐Mediated Tetrazole—Ene Cycloaddition as a Versatile Platform for Fullerene Conjugation.
Authors: Sugawara Yuuki , Jasinski Nils , Kaupp Michael , Welle Alexander , Zydziak Nicolas , Blasco Eva , Barner‐Kowollik Christopher 
Published: September 2015

AbstractAn efficient methodology for modular fullerene functionalization via photo‐induced nitrile imine‐mediated tetrazole—ene cycloaddition (NITEC) is introduced.
ChemInform Abstract: Use of the Thiophenesulfonyl Protecting Group in the Catalytic, Asymmetric Synthesis of Unprotected β‐Lactams.
Authors: Wang Yazhong , Calter Michael A. 
Published: September 2015

AbstractThe thiophenesulfonyl group is found to be compatible with the catalytic, enantioselective synthesis of β‐lactams (III) from acid chlorides (II) and sulfonyl imines (I).
ChemInform Abstract: Iodine‐Catalyzed Radical Oxidative Annulation for the Construction of Dihydrofurans and Indolizines.
Authors: Tang Shan , Liu Kun , Long Yue , Gao Xinlong , Gao Meng , Lei Aiwen 
Published: September 2015

AbstractThe iodine‐catalytic system can be scaled up to 20 mmol with an excellent efficiency.
ChemInform Abstract: Copper‐Catalyzed [4 + 1] Annulation Between α‐Hydroxy Ketones and Nitriles: An Approach to Highly Substituted 3(2H)‐Furanones.
Authors: He Haitao , Qi Chaorong , Hu Xiaohan , Ouyang Lu , Xiong Wenfang , Jiang Huanfeng 
Published: September 2015

AbstractThe facile and highly efficient method allows the approach to a broad spectrum of the required biologically interesting furanone structures.
ChemInform Abstract: Regioselective Synthesis of Multisubstituted Furans via Copper‐Mediated Coupling Between Ketones and β‐Nitrostyrenes.
Authors: Ghosh Monoranjan , Mishra Subhajit , Hajra Alakananda 
Published: September 2015

AbstractA broad spectrum of di‐ and trisubstituted furans is available in a completely regioselective manner following conditions A).
ChemInform Abstract: Synthesis and Characterization of Tetraarylporphyrins in the Presence of Nano‐TiCl4·SiO2.
Authors: Zamani Leila , Mirjalili Bi Bi Fatemeh 
Published: September 2015

AbstractSynthesis of tetraarylporphyrins by the coupling of an aromatic aldehyde and pyrrole using nano‐TiCl4·SiO2 as a mild, inexpensive, and highly efficient catalyst is studied.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Allylic Amination of Racemic Butadiene Monoxide with Isatin Derivatives.
Authors: Li Gen , Feng Xiangqing , Du Haifeng 
Published: September 2015

AbstractA palladium‐catalyzed asymmetric allylic amination of racemic butadiene monoxide with isatins and their derivatives as nucleophiles under mild reaction conditions is successfully realized using a chiral P/terminal‐olefin ligand.
ChemInform Abstract: Iodine‐Mediated C—H Functionalization of sp, sp2, and sp3 Carbon: A Unified Multisubstrate Domino Approach for Isatin Synthesis.
Authors: Satish Gandhesiri , Polu Ashok , Ramar Thangeswaran , Ilangovan Andivelu 
Published: September 2015

AbstractThe approach to the desired isatins is possible starting from 2′‐aminophenylacetylenes, 2′‐aminostyrenes and 2′‐amino‐β‐ketoesters via oxidative amidation in the presence of specified amounts of iodine.
ChemInform Abstract: Efficient Synthesis of Chiral Indolines Using an Imine Reductase from Paenibacillus lactis.
Authors: Li Hao , Luan Zheng‐Jiao , Zheng Gao‐Wei , Xu Jian‐He 
Published: September 2015

Abstract2‐Phenyl‐3,3‐dimethyl‐3H‐indole and 2′‐Methylspiro[cyclohexane‐1,3′‐(3′H)‐indole] don′t yield the desired products using the presented reaction conditions.
ChemInform Abstract: Stereocontrolled Intramolecular Iron‐Mediated Tandem [6 + 2]‐Ene‐Type Diene/Dienol Ether Double Cyclization Reactions.
Authors: Pearson Anthony J. , Zhang Sheng 
Published: September 2015

AbstractThe photothermally induced title reaction is catalyzed by a pendant iron carbonyl moiety and provides diastereomerically pure spirotricyclic products in high yields.
ChemInform Abstract: A New Type of Lewis Acid‐Base Bifunctional M(salphen) (M: Zn, Cu and Ni) Catalysts for CO2 Fixation.
Authors: Ren Yanwei , Chen Jungui , Qi Chaorong , Jiang Huanfeng 
Published: September 2015

AbstractThe catalyst can be easily recycled and reused at least 5 times.
ChemInform Abstract: An Efficient Synthesis of gem‐Diiodoolefins and (E)‐Iodoalkenes from Propargylic Amides with a Cu(I)/Cu(III) Cycle.
Authors: Zhang Shuo , Chen Ying , Wang Jianwu , Pan Yue , Xu Zhenghu , Tung Chen‐Ho 
Published: September 2015

AbstractThe resulting mono‐ and diiodoalkenes can be used in Suzuki, Heck and Sonogashira coupling reactions furnishing the corresponding tri‐ and tetrasubstituted alkenes.
ChemInform Abstract: A Convenient Strategy to 2,4,5‐Triaryl and 2‐Alkyl‐4,5‐diaryl Oxazole Derivatives Through Silver‐Mediated Oxidative C—O Cross Coupling/Cyclization.
Authors: Sarkar Rajib , Mukhopadhyay Chhanda 
Published: September 2015

AbstractA simple protocol is developed for the synthesis of oxazoles from 1,2‐diketones and primary amines via Ag(I)‐mediated Cα(sp3)—H activation of the amines followed by oxidative C—O cross coupling and cyclization.
ChemInform Abstract: Facile Synthesis of 2,5‐Disubstituted Thiazoles from Terminal Alkynes, Sulfonyl Azides, and Thionoesters.
Authors: Miura Tomoya , Funakoshi Yuuta , Fujimoto Yoshikazu , Nakahashi Junki , Murakami Masahiro 
Published: September 2015

AbstractProcedures are evaluated for the preparation of various thiazole structures either from triazole precursors (prepared from terminal alkynes and sulfonyl azides) or directly starting with their formation in a one‐pot approach.
ChemInform Abstract: Access to Substituted Dihydrothiopyrano[2,3‐b]indoles via Sequential Rearrangements During S‐Alkylation and Au‐Catalyzed Hydroarylation on Indoline‐2‐thiones.
Authors: Jha Mukund , Shelke Ganesh M. , Cameron T. Stanley , Kumar Anil 
Published: September 2015

AbstractVarious cyclization precursors are prepared from indoline‐2‐thiones and selected unsaturated alcohols.
ChemInform Abstract: Synthesis of Cinnolin‐3(2H)‐one Derivatives from Rh‐Catalyzed Reaction of Azobenzenes with Diazotized Meldrum′s Acid.
Authors: Son Jeong‐Yu , Kim Sunghwa , Jeon Woo Hyung , Lee Phil Ho 
Published: September 2015

AbstractBoth symmetrical and unsymmetrical azobenzenes can be used in the title synthesis.
ChemInform Abstract: Efficient Synthesis of Pyrrolo[2,3‐d]pyrimidines via a Cu(I)/6‐Methylpicolinic Acid Catalyzed Coupling Reaction
Authors: Jiang Xi , Sun Dequn , Jiang Yongwen , Ma Dawei 
Published: September 2015

Abstractof 4‐amino‐5‐bromopyrimidines with alkynes
ChemInform Abstract: Rearrangement of Oxazolo[3,2‐a]pyridines as an Approach of Synthesizing Aza[3.3.2]cyclazines.
Authors: Babaev Eugene V. , Nevskaya Aleksandra A. , Dlynnikh Ilya V. 
Published: September 2015

AbstractDihydropyridine derivative (I) is used as starting material for oxazolopyridinium perchlorate (V) and indolizine derivatives (VII), (IX), and (XI).
ChemInform Abstract: Nitrosation of 5H‐Thiazolo[3,2‐a]pyrimidin‐3(2H)‐ones.
Authors: Lashmanova Evgenia A. , Shiryaev Andrey K. 
Published: September 2015

AbstractThe title nitrosation reaction enables the formation of 2‐(hydroxyimino)thiazolo[3,2‐a]pyrimidinones (II) in moderate yields.
ChemInform Abstract: Ligand‐Free Copper‐Catalyzed Coupling of α‐Amino Acids with N‐Boc‐2‐iodoanilines for the Synthesis of Enantiopure 3‐Substituted Dihydroquinoxalinones.
Authors: Luo Sheng , De Brabander Jef K. 
Published: September 2015

AbstractThe initially obtained N‐arylated α‐amino acids (III) are subsequently transformed into enantiomerically pure 3‐substituted dihydroquinoxalinones (IV) via Boc‐deprotection/condensation.
ChemInform Abstract: Synthesis and Biological Activity of Fluorinated 7‐Benzylamino‐2‐phenyl‐1,2,4‐triazolo[1,5‐a][1,3,5]triazin‐5‐amines.
Authors: Dolzhenko Anna V. , Tan Bee Jen , Chiu Gigi Ngar Chee , Chui Wai Keung , Dolzhenko Anton V. 
Published: September 2015

Abstract5‐Azapurine derivatives (V) having fluorinated benzyl groups are developed and tested for anticancer and antiangiogenic properties.
Influence of Structural Parameters on the Self‐Association Properties of Anti‐HIV Catanionic Dendrimers
Authors: Perez‐Anes Alexandra , Rodrigues Fernanda , Caminade Anne‐Marie , Stefaniu Cristina , Tiersch Brigitte , Turrin Cédric‐Olivier , Blanzat Muriel 
Published: September 2015

AbstractThe self‐association properties of anti‐HIV catanionic dendrimers as multivalent galactosylceramide (GalCer)‐derived inhibitors are presented. The study was designed to elucidate the origin of the relatively high cytotoxicity values of these anti‐HIV catanionic dendrimers, which have previously been found to exhibit in vitro anti‐HIV activity in the submicromolar range. The physicochemical properties of these catanionic dendrimers were studied to tentatively correlate the structural parameters with self‐association and biological properties. We can conclude from this study that the absence of correlation between the hydrophobicity and the cytotoxicity of the catanionic systems could be explained by the partial segregation of the different partners of the catanionic entities.