bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allergic Inflammation Is Associated With Coronary Instability and a Worse Clinical Outcome After Acute Myocardial Infarction
Authors: Niccoli Giampaolo , Calvieri Camilla , Flego Davide , Scalone Giancarla , Imaeva Asya , Sabato Vito , Schiavino Domenico , Liuzzo Giovanna , Crea Filippo 
Published: August 2015

Background—
The role of allergic inflammation in acute coronary syndromes (ACS) has not been clearly defined to date. Aim of this study was to assess eosinophil and basophil activation in ACS and the prognostic role of eosinophil cationic protein in ST-segment–elevation myocardial infarction.

Methods and Results—

In a cross-sectional study, we prospectively enrolled 51 patients undergoing percutaneous coronary intervention (60.8% patients with ACS and 39.2% with stable angina). Flow cytometry analysis assessed CD66b, CD69, and CD203c median fluorescence intensity expression. In a follow-up study, 181 patients presenting with ST-segment–elevation myocardial infarction, undergoing primary percutaneous coronary intervention, were prospectively enrolled with a follow-up of 24 months. Eosinophil activation (CD66b) was similar in patients with ACS and stable angina (6.61 [4.91–7.72] versus 6.62 [5.27–8.73],
P
=0.63), whereas eosinophil degranulation (CD69) and basophil activation (CD203c) were higher in ACS patients compared with stable angina patients (1.38 [1.16–1.52] versus 1.17 [1–1.31],
P
=0.01); 0.97 [0.89–1.11] versus 0.92 [0.87–0.95],
P
=0.03, respectively). Eosinophil cationic protein serum levels were significantly higher in ST-segment–elevation myocardial infarction patients with major adverse cardiac events as compared with those without (21.1 [10.37–25.65] versus 7.83 [3.37–12.8] μg/L,
P
=0.01) and in patients with thrombus score >3 compared with those with thrombus score ≤3 (15.0 [9.8–24.7] versus 5.2 [3.5–22.9] μg/L,
P
=0.006). Eosinophil cationic protein serum levels predicted major adverse cardiac events during follow-up (odds ratio =1.041, 95% confidence interval 1.012–1.071,
P
=0.005). C-reactive protein serum levels showed a borderline statistical significance (odds ratio =0.904, 95% confidence interval 0.806–1.014,
P
=0.085).

Conclusions—
These findings are the first demonstration of in vivo eosinophil degranulation and basophil activation during ACS and of the prognostic role of eosinophil cationic protein in ST-segment–elevation myocardial infarction.
Occurrence and Predictors of Falls in People With Stroke
Authors: Minet Lisbeth Rosenbek , Peterson Elizabeth , von Koch Lena , Ytterberg Charlotte 
Published: August 2015

Background and Purpose—
The purpose was to investigate the occurrence of self-reported falls in people with stroke at 3, 6, and 12 months and 6 years post stroke and predictors for falls during 6 years.

Methods—
A prospective study involving 121 people with stroke. Data were obtained through structured interviews and assessments. Generalized estimating equation modeling using proportional odds was used to explore the predictive value of fall history, functioning/disability, and personal factors during 6 years.

Results—
The proportion of fallers constituted of 35%, 26%, 33%, and 35% of the sample at 3, 6, and 12 months and 6 years of follow-up, respectively. Higher perceived effect of stroke on activities of daily living (odds ratio, 1.37; 95% confidence interval, 1.04–1.80), falls at 3 months (odds ratio, 1.0; 95% confidence interval, 1.01–3.94), and no gait/balance disability at baseline (odds ratio, 7.29; 95% confidence interval, 1.99–26.73) were predictors for future falls. During the 6 years, the odds for a fall decreased for participants with gait/balance disability at baseline but increased for those with no gait/balance disability.

Conclusions—
Results highlight the importance of performing fall risk evaluations over time among people with stroke, even when gait and balance functioning initially post stroke is good.
Mechanisms of Stratospheric and Tropospheric Circulation Response to Projected Arctic Sea Ice Loss*
Authors: Sun Lantao , Deser Clara , Tomas Robert A. 
Published: August 2015

Abstract
The impact of projected Arctic sea ice loss on the atmospheric circulation is investigated using the Whole Atmosphere Community Climate Model (WACCM), a model with a well-resolved stratosphere. Two 160-yr simulations are conducted: one with surface boundary conditions fixed at late twentieth-century values and the other with identical conditions except for Arctic sea ice, which is prescribed at late twenty-first-century values. Their difference isolates the impact of future Arctic sea ice loss upon the atmosphere. The tropospheric circulation response to the imposed ice loss resembles the negative phase of the northern annular mode, with the largest amplitude in winter, while the less well-known stratospheric response transitions from a slight weakening of the polar vortex in winter to a strengthening of the vortex in spring. The lack of a significant winter stratospheric circulation response is shown to be a consequence of largely cancelling effects from sea ice loss in the Atlantic and Pacific sectors, which drive opposite-signed changes in upward wave propagation from the troposphere to the stratosphere. Identical experiments conducted with Community Atmosphere Model, version 4, WACCM’s low-top counterpart, show a weaker tropospheric response and a different stratospheric response compared to WACCM. An additional WACCM experiment in which the imposed ice loss is limited to August–November reveals that autumn ice loss weakens the stratospheric polar vortex in January, followed by a small but significant tropospheric response in late winter and early spring that resembles the negative phase of the North Atlantic Oscillation, with attendant surface climate impacts.
Performance Evaluation of the Canadian Precipitation Analysis (CaPA)
Authors: Lespinas Franck , Fortin Vincent , Roy Guy , Rasmussen Peter , Stadnyk Tricia 
Published: August 2015

Abstract
This paper presents an assessment of the operational system used by the Meteorological Service of Canada for producing near-real-time precipitation analyses over North America. The Canadian Precipitation Analysis (CaPA) system optimally combines available surface observations with numerical weather prediction (NWP) output in order to produce estimates of precipitation on a 15-km grid at each synoptic hour (0000, 0600, 1200, and 1800 UTC). The validation protocol used to assess the quality of the CaPA has demonstrated the usefulness of the system for producing reliable estimates of precipitation over Canada, even in areas with few or no weather stations. The CaPA is found to be better in autumn, spring, and winter than in summer. This is because of the difficulty in correctly producing convective precipitation in the NWP because of the low spatial resolution of the meteorological model. An investigation of the quality of the precipitation analyses in the 15 terrestrial ecozones of Canada indicates the need to have a sufficient number of observations (at least ~1.17 stations per 10 000 km2) in order to produce a precipitation analysis that is significantly better than the raw NWP product. Improvements of the CaPA system by including provincial networks as well as radar and satellite information are expected in the future.
Improved Nowcasts by Blending Extrapolation and Model Forecasts
Authors: Hwang Yunsung , Clark Adam J. , Lakshmanan Valliappa , Koch Steven E. 
Published: August 2015

Abstract
Planning and managing commercial airplane routes to avoid thunderstorms requires very skillful and frequently updated 0–8-h forecasts of convection. The National Oceanic and Atmospheric Administration’s High-Resolution Rapid Refresh (HRRR) model is well suited for this purpose, being initialized hourly and providing explicit forecasts of convection out to 15 h. However, because of difficulties with depicting convection at the time of model initialization and shortly thereafter (i.e., during model spinup), relatively simple extrapolation techniques, on average, perform better than the HRRR at 0–2-h lead times. Thus, recently developed nowcasting techniques blend extrapolation-based forecasts with numerical weather prediction (NWP)-based forecasts, heavily weighting the extrapolation forecasts at 0–2-h lead times and transitioning emphasis to the NWP-based forecasts at the later lead times. In this study, a new approach to applying different weights to blend extrapolation and model forecasts based on intensities and forecast times is applied and tested. An image-processing method of morphing between extrapolation and model forecasts to create nowcasts is described and the skill is compared to extrapolation forecasts and forecasts from the HRRR. The new approach is called salient cross dissolve (Sal CD), which is compared to a commonly used method called linear cross dissolve (Lin CD). Examinations of forecasts and observations of the maximum altitude of echo-top heights ≥18 dBZ and measurement of forecast skill using neighborhood-based methods shows that Sal CD significantly improves upon Lin CD, as well as the HRRR at 2–5-h lead times.
Biomarkers of pulmonary hypertension in patients with scleroderma: a case–control study
Authors: McMahan Zsuzsanna , Schoenhoff Florian , Van Eyk Jennifer E. , Wigley Fredrick M. , Hummers Laura K. 
Published: August 2015

Abstract
Introduction
Significant pulmonary vascular disease is a leading cause of death in patients with scleroderma, and early detection and early medical intervention are important, as they may delay disease progression and improve survival and quality of life. Although several biomarkers have been proposed, there remains a need to define a reliable biomarker of early pulmonary vascular disease and subsequent development of pulmonary hypertension (PH). The purpose of this study was to define potential biomarkers for clinically significant pulmonary vascular disease in patients with scleroderma.

Methods
The circulating growth factors basic fibroblast growth factor, placental growth factor (PlGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor, and soluble VEGF receptor 1 (sFlt-1), as well as cytokines (interleukin [IL]-1β IL-2, IL-4, IL-5, IL-8, IL-10, IL-12, IL-13, tumor necrosis factor-α, and interferon-γ), were quantified in patients with scleroderma with PH (n = 37) or without PH (n = 40). In non-parametric unadjusted analyses, we examined associations of growth factor and cytokine levels with PH. In a subset of each group, a second set of earlier samples, drawn 3.0±1.6 years earlier, were assessed to determine the changes over time.

Results
sFlt-1 (p = 0.02) and PlGF (p = 0.02) were higher in the PH than in the non-PH group. sFlt-1 (ρ = 0.3245; p = 0.01) positively correlated with right ventricular systolic pressure. Both PlGF (p = 0.03) and sFlt-1 (p = 0.04) positively correlated with the ratio of forced vital capacity to diffusing capacity for carbon monoxide (DLCO), and both inversely correlated with DLCO (p = 0.01). Both PlGF and sFlt-1 levels were stable over time in the control population.

Conclusions
Our study demonstrated clear associations between regulators of angiogenesis (sFlt-1 and PlGF) and measures of PH in scleroderma and that these growth factors are potential biomarkers for PH in patients with scleroderma. Larger longitudinal studies are required for validation of our results.
SLiMScape 3.x: a Cytoscape 3 app for discovery of Short Linear Motifs in protein interaction networks
Authors: Olorin Emily , O'Brien Kevin T. , Palopoli Nicolas , Pérez-Bercoff Åsa , Shields Denis C. , Edwards Richard J. 
Published: August 2015

Short linear motifs (SLiMs) are small protein sequence patterns that mediate a large number of critical protein-protein interactions, involved in processes such as complex formation, signal transduction, localisation and stabilisation. SLiMs show rapid evolutionary dynamics and are frequently the targets of molecular mimicry by pathogens. Identifying enriched sequence patterns due to convergent evolution in non-homologous proteins has proven to be a successful strategy for computational SLiM prediction. Tools of the SLiMSuite package use this strategy, using a statistical model to identify SLiM enrichment based on the evolutionary relationships, amino acid composition and predicted disorder of the input proteins. The quality of input data is critical for successful SLiM prediction. Cytoscape provides a user-friendly, interactive environment to explore interaction networks and select proteins based on common features, such as shared interaction partners. SLiMScape embeds tools of the SLiMSuite package for de novo SLiM discovery (SLiMFinder and QSLiMFinder) and identifying occurrences/enrichment of known SLiMs (SLiMProb) within this interactive framework. SLiMScape makes it easier to (1) generate high quality hypothesis-driven datasets for these tools, and (2) visualise predicted SLiM occurrences within the context of the network. To generate new predictions, users can select nodes from a protein network or provide a set of Uniprot identifiers. SLiMProb also requires additional query motif input. Jobs are then run remotely on the SLiMSuite server (http://rest.slimsuite.unsw.edu.au) for subsequent retrieval and visualisation. SLiMScape can also be used to retrieve and visualise results from jobs run directly on the server. SLiMScape and SLiMSuite are open source and freely available via GitHub under GNU licenses.
Hybrid interfaces in layered hydroxides: magnetic and multifunctional superstructures by design
Authors: Rabu Pierre , Delahaye Emilie , Rogez Guillaume 
Published: August 2015

AbstractThis article is a critical review on layered hybrid organic-inorganic functional structures. We specially discuss a series of results concerning the design of magnetic and multiproperty systems derived from hybridization of layered transition metal hydroxides. A series of hybrid materials showing original magnetic properties are reviewed, which were prepared by functionalization of layered simple hydroxides (LSH) of the general formula M
Excitatory and inhibitory conversive experiences: neurobiological features involving positive and negative conversion symptoms
Authors: Río-Casanova Lucía del , González Anabel , Páramo Mario , Brenlla Julio 
Published: August 2015

AbstractPrevious reviews have focused on neurobiological and physiological mechanisms underlying conversion disorder, but they do not usually distinguish between negative and positive conversion symptoms. Some authors have proposed that different phenomena should underlie both situations and that diverse emotion regulation strategies (under- vs. overregulation of affect) should be related to different internal experiences (excitatory experiences with hyperarousal manifestations vs. inhibitory experiences coexisting with hypoarousal states, respectively). After a careful review of the literature, we conclude that there is not a unique theory comprising all findings. Nevertheless, we have also collected some replicated findings that should be salient. Patients manifesting positive conversion symptoms tended to present with limbic hyperfunction, not sufficiently counteracted by prefrontal control. This leads to underregulation of affect mechanisms, increased emotional reactivity and autonomic hyperarousal. The opposite pattern (with a prefrontal overfunction working as a cognitive brake over the limbic system) has been described during negative conversion manifestations. We also highlight the influence of fronto-limbic circuits over cortico-striato-thalamo-cortical circuits’ regulation, whose horizontal and vertical synchronization has been at the spotlight of the genesis of conversion and dissociative disorders.
Investigation of Detailed Flow in a Variable Turbine Nozzle
Authors: Liu Yixiong , Lao Dazhong , Yang Ce 
Published: August 2015

AbstractThe detailed flow behavior of the nozzle channel of a variable turbine is presented in this paper. The numerical model of a variable nozzle turbine was developed by using computational fluid dynamics method, and validated by the measured performance data of the turbine. Two opening positions of the nozzle vane, as well as two inlet conditions of the nozzle representing different vane loadings, were investigated to evaluate the clearance flow behaviors. It is shown that the channel shock waves are produced at proper conditions, such as small opening and large inlet pressure, which has significant impact on the end wall clearance leakage flow. When the leakage flows through the end wall clearance from the pressure side to the suction side encountering by the main stream, and the leakage vortex is formed. It is found that this leakage vortex gradually enhanced from the trailing edge to the middle edge.
Evidence of Extra Capacity in Conversion Reaction of Ruthenium Oxide: A Cyclic Voltammetry Study
Authors: Meda Lamartine , Douglas Lacey , Navulla Anantharamulu 
Published: August 2015

ABSTRACTSynthesis and understanding of metal oxide nanomaterials with improved electrochemical properties can play a big role in the development of high capacity electrochemical cells for application in lithium-ion batteries (LIBs). Metal oxide nanostructured materials have shown exceptional storage capabilities through conversion reaction. But, excess reversible capacity is usually observed in these systems. To understand the origin of the excess capacity, we have prepared nanostructured ruthenium oxide (RuO2) directly on stainless steel current collectors using low pressure chemical vapor deposition. The crystal structure of the as-prepared materials were examined by powder X-ray diffraction and indexed to the rutile structure. Field emission scanning electron microscopy revealed 3D pyramidal shape architectures that self-assembled into columns creating high surface area. Galvanostatic charge-discharge measurements were performed versus Li/Li+ in the range of 4.0 to 0.1 V. We have observed a reversible capacity of 1150 mAh/g which is equivalent to 5.70 Li per mol of RuO2. The expected capacity of RuO2 is 806 mAh/g which is approximately 4 Li per mol of RuO2 based on this equation: RuO2 + Li + 4e- ↔ Ru0 + 2Li2O. The excess capacity is approximately 435 mAh/g. The origin of the excess capacity was investigated using cyclic voltammetry, which was performed at two different range of voltage.
Wettability and Oil Recovery by Polymer and Polymer Particles
Authors: Shiran Behruz Shaker , Skauge Arne 
Published: August 2015

AbstractWettability of the reservoir is a major parameter controlling the oil production profile during waterflooding, the breakthrough of injection water, the final oil recovery, and the residual oil saturation (Sor) trapped in the pore structure. Therefore identifying the wettability of the reservoir will lead to appropriate implementation of improved/enhanced oil recovery practices in order to improve the economy of the project.The initial wettability state of the reservoir rock has crucial impact on the performance of polymer flooding process. Polymer flow behavior in the porous media including pressure build up, polymer retention due to adsorption mechanism, resistance factor, and residual resistance factor can be affected by wettability of the porous media. This, in turn, would affect the technical and economic success or failure of the polymer flooding project. Unfortunately, in the petroleum literature there is very little data regarding the effect of wettability on oil recovery by polymer flooding.In this paper we investigate the propagation of polymer and polymer particles under different wettability states. The flow behavior of polymer solution including pressure build up, resistance factor (Fr), and residual resistance factor (Frr) are compared at different wettability states. Moreover the oil recovery efficiency by polymer flooding at different wettability states is presented in this paper.
An Evaluation on Strong Base ASP Flooding Efficiency of Multiple Layers
Authors: Rue Song , Dong Zhang , Cong Xue , Hong Chen , Fajiang Ran , Ji Li , Mingchuan Zhao , Bo Li , Chunhui Yu , Tianyi Wang , Xiwen Zuo , Jian Ding , Xin Zhang , Zigang Zhang 
Published: August 2015

Abstract
Strong base ASP flooding technology can improve swept volume, displacement efficiency and oil recovery greatly. It shows encouring prospects for sustainable development of the maturing oilfield. So In this paper, with the help of data from coring wells and newly-drilled wells after ASP flooding, we has strengthened understanding of the reservoir.By using numerical simulation, carrying out lab core displacement test, microscopic oil displacement test, and using techniques such as nuclear magnetic resonance, electron microscopic detection and electrical logging curves of newly-drilled wells and so on, we have found out petrophysical changes in reservoirs after ASP, evaluated oil displacement efficiency of different locations, and systematically analyzed influcing factors on occurrence of displacement efficiency differences. The study results show that the oil displacing efficiency increased by 14.7% after strong alkali ASP flooding, and the thickness of heavy-water-flooded layer increasedby 26.0%. Chemical reactions and ion exchanges between ASP fluid, rock and clay minerals lead to changes of reservoir physical properties: Shale content increased; median grain diameter decreased; Permeability of intervals lowered and the wettability is converted to hydrophilicity. petrophysical changes of the reservoir is the main factor influencing oil displacement efficiency.The research result provides a guidance to explore potentialities of ASP flooding during the commercial popularization process and it is an important reference for further studies on enhancing oil recovery techniques after ASP flooding.