bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial clustering of overweight/obesity among women in India: Insights from the latest National Family Health Survey
Authors: Chakrabarty Mahashweta , Let Subhojit 
Published: July 2024

Background
Overweight/obesity has become global health concern with increasing prevalence. This study examined district-level disparities and spatial clustering of overweight/obesity among women of reproductive age (WRA) in India using the latest National Family Health Survey-5 (2019–2021) data.

Method
Information of 623,656 women aged 15 to 49 from the NFHS-5 (2019–2021) were analysed in this study. The outcome variable was BMI as classified by the world health organisation (WHO). Utilising Global Moran’s I, Anselin’s Local Moran’s I, and spatial regression models spatial clustering and associated factors were analysed.

Result
The study found that 24% (95% CI: 23.8–24.3) of WRA in India were overweight/obese in 2019–21. The prevalence was greatest in Punjab (41%) and lowest in Meghalaya (11%). Additionally, the Global Moran’s I value for the outcome variable was 0.73, indicating a positive spatial autocorrelation in the overweight/obesity. Districts of Tamil Nadu, Andhra Pradesh, Karnataka, Kerala, Telangana, Punjab, Himachal Pradesh, Jammu & Kashmir, Haryana, and Delhi were hotspots of overweight/obesity. Several factors of overweight/obesity among WRA were identified, including place of residence (β: 0.034, p: 0.011), parity (β: 0.322, p: 0.002), social group (β: -0.031, p: 0.016), religion (β: -0.044, p: <0.001), household wealth status (β: 0.184, p: <0.001), mass-media exposure (β: 0.056, p: 0.031), and diabetes (β: 0.680, p: <0.001).

Conclusion
The study emphasizes the importance of targeted interventions and region-specific strategies, while also stressing the need to address associated factors to develop effective public health initiatives aimed at reducing overweight/obesity prevalence among WRA in India.
Estimation of COVID-19 vaccine effectiveness against infections and severe outcomes using routine surveillance data in Kosovo, July—September 2021
Authors: Rashiti-Bytyçi Albiona , White Johansson Emily , Kaçaniku-Gunga Pranvera , Danis Kostas , Schoeps Anja , Dörre Achim , Fetaj Fetije , Kalaveshi Arijana 
Published: July 2024

Background
COVID-19 vaccines have proven effective against severe outcomes in many settings, yet vaccine effectiveness (VE) estimates remain lacking for Kosovo. We aimed to estimate VE against COVID-19 infections, hospitalisations, and deaths for one and two vaccine doses during the fourth pandemic wave in July—September 2021, the period when vaccination initially became widely available.

Methods
We analysed routine surveillance data to define cases and vaccination status as partially (one dose) or completely (two doses) vaccinated. We used the screening method to calculate the proportion of cases with the outcomes vaccinated (PCV). The proportion of the population vaccinated (PPV) was based on numbers vaccinated and the Kosovo population estimate on 30/09/2021.

Results
Between July—September 2021, 51,804 COVID-19 cases were reported in Kosovo with 9.3% of cases partially and 3.4% completely vaccinated. Estimated vaccine effectiveness for one dose was 93.1% (95%CI:92.9–93.2%) for infections, 90.3% (95%CI:88.8–91.7%) for hospitalisations, and 90.3% (95%CI:88.4–92.1%) for deaths. Estimated vaccine effectiveness for two doses was 97.8% (95%CI:97.6–97.9%) for infections, 94.5% (95%CI:93.3–95.6%) for hospitalisations, and 94.2% (95%CI: 93.7–96.5%) for deaths.

Conclusions
This study provides real-world evidence for COVID-19 vaccine effectiveness in Kosovo using routine administrative data sources and the screening method. COVID-19 vaccine effectiveness against infections and severe outcomes in Kosovo was higher with two vaccine doses than one dose, which is in accordance with findings from other study designs and settings. Using the screening method in our study reflects an important initial methodology for estimating vaccine effectiveness with routine surveillance that may be particularly important for low- and middle-income settings with less robust surveillance systems or fewer opportunities to conduct more robust vaccine effectiveness study designs.
Effectiveness of a suction device for containment of pathogenic aerosols and droplets
Authors: Lordly Kai , Karataş Ahmet E. , Lin Steve , Umapathy Karthi , Mohindra Rohit 
Published: July 2024

Background
As the global community begins recovering from the COVID-19 pandemic, the challenges due to its aftermath remain. This health crisis has highlighted challenges associated with airborne pathogens and their capacity for rapid transmission. While many solutions have emerged to tackle this challenge, very few devices exist that are inexpensive, easy to manufacture, and versatile enough for various settings.

Methods
This paper presents a novel suction device designed to counteract the spread of aerosols and droplets and be cost-effective and adaptable to diverse environments. We also conducted an experimental study to evaluate the device’s effectiveness using an artificial cough generator, a particle counter, and a mannequin in an isolated system. We measured droplet removal rates with simulated single and repeated cough incidents. Also, measurements were taken at four distinct areas to compare its effectiveness on direct plume versus indirect particle removal.

Results
The device reduced airborne disease transmission risk, as evidenced by its capacity to decrease the half-life of aerosol volume from 23.6 minutes to 15.6 minutes, effectively capturing aerosol-sized droplets known for their extended airborne persistence. The suction device lessened the peak total droplet volume from peak counts. At 22 minutes post peak droplet count, the count had dropped 24% without the suction device and 43% with the suction device.

Conclusions
The experiment’s findings confirm the suction device’s capability to effectively remove droplets from the environment, making it a vital tool in enhancing indoor air quality. Given the sustained performance of the suction device irrespective of single or multiple cough events, this demonstrates its potential utility in reducing the risk of airborne disease transmission. 3D printing for fabrication opens the possibility of a rapid iterative design process, flexibility for different configurations, and rapid global deployment for future pandemics.
Prevalence of cardiovascular drug-related adverse drug reactions consultations in UK primary care: A cross-sectional study
Authors: Insani Widya N. , Whittlesea Cate , Wei Li 
Published: July 2024

Background
Adverse drug reactions (ADRs) represent a significant barrier to achieve optimal treatment outcomes. Cardiovascular drugs, including antihypertensive drugs, lipid-lowering drugs, and antithrombotic drugs, are among the most prescribed medications in the primary care setting.

Objectives
To estimate the prevalence of cardiovascular drug-related ADRs consultations in United Kingdom (UK) primary care and identify risk factors of these ADRs.

Methods
This was a cross-sectional study of cardiovascular drug users between 2000–2019 using UK IQVIA Medical Research Data. ADRs consultations were identified using database screening method employing standardised designated codes. The overall and annual age-standardised prevalence was estimated using direct standardisation method using 2019 mid-year UK population. Risk factors of ADRs consultations were estimated using logistic regression model stratified by therapeutic areas.

Results
The standardised prevalence of consultations related to cardiovascular drugs ADRs was 10.60 (95% CI. 10.46, 10.75) per 1000 patients. Patients aged 70–79 years had the highest occurrence of ADRs consultations. The most frequently drug classes implicated in the ADRs consultations were statins (n = 9,993 events, 27.09%), beta-blockers (n = 8,538 events, 23.15%), ACEIs/ARBs (n = 8,345 events, 22.62%), and aspirin (n = 6,482 events, 17.57%). Risk factors of ADRs consultations were previous history of cardiovascular diseases, e.g., myocardial infarction and stroke; advanced age, comorbidities; diabetes and dyslipidaemia; and polypharmacy.

Conclusions
The burden of cardiovascular drug-related ADRs consultations in primary care was considerable. Statins, beta-blockers, ACEIs/ARBs, and aspirin were the most frequently implicated drug classes. Closer clinical monitoring should be performed for patients affected by the ADRs to mitigate the risk of suboptimal treatment outcomes.
Latinx youth’s and parents’ covid-19 beliefs, vaccine hesitancy and vaccination rates: Longitudinal associations in a community sample
Authors: Mantina Namoonga M. , Ngaybe Maiya G. Block , Zeiders Katharine H. , Osman Kayla M. , Wilkinson-Lee Ada M. , Landor Antoinette M. , Hoyt Lindsay T. 
Published: July 2024

Introduction
The Latinx population has the second highest COVID-19 death rate among racial/ethnic groups in the United States and less than half of Latinx youth aged 5–17 years old completed their COVID-19 primary vaccination series as of September 2022. COVID-19 vaccine misinformation detrimentally impacts vaccination rates. In this study, we examined factors that predicted Latinx youth COVID-19 vaccine hesitancy and vaccination status.

Methods
A community-based sample of 290 Latinx parent and adolescent dyads from a Southwestern metropolitan area of the United States who were recruited to complete an online survey at baseline at T1 (August 2020 –March 2021) and one year later. We tested a longitudinal mediation model in which we examined individual and family factors that would predict youth COVID-19 vaccine hesitancy and vaccination status over time.

Results
Youth’s pandemic disbelief (i.e., the belief that the COVID-19 pandemic is a conspiracy or not real) predicted greater youth’s COVID-19 vaccine hesitancy, and in turn, a lower likelihood of youth’s COVID-19 vaccination. Youth’s pandemic disbelief also predicted greater parent’s vaccination hesitancy which, in turn, predicted greater youth’s vaccination hesitancy and a lower likelihood of COVID-19 vaccination. Parents’ pandemic disbelief predicted their own COVID-19 hesitancy, but not youth hesitancy.

Discussion
Our study findings provide initial evidence that general pandemic disbelief was a significant driver of vaccine hesitancy and vaccination among Latinx families. The study contributes to the limited research investigating COVID-19 vaccination in the Latinx community and among Latinx youth, further aiding how COVID-19 vaccine disparities can be mitigated among racial/ethnic populations.
Comparative efficacy and safety of traditional Chinese medicine injections in patients with transient ischemic attack: A systematic review and network meta-analysis
Authors: Yi Yunhao , Zhang Guangheng , Lv Shimeng , Rong Yuanhang , Liu Hui , Li Ming 
Published: July 2024

Objectives
Traditional Chinese medicine (TCM) injections are extensively utilized for the treatment of transient ischemic attack (TIA). However, it remains unclear which specific TCM injection exhibits superior efficacy. In this study, we conducted a network meta-analysis to compare the clinical efficacy and safety of various TCM injections in the treatment of TIA, with the aim of identifying the optimal treatment regimen.

Design
We searched seven databases to collect information on nine TCM injections for the treatment of transient randomized controlled trials (RCTs) for the treatment of transient ischemic attacks were collected from the establishment to August 2023. The methodological quality and risk of bias were assessed using the RoB 2.0 evaluation tool, and reticulated Meta-analysis was performed using R software and Stata software.

Results
We ultimately included 58 RCTs involving 5502 patients and comprising 9 TCM injections. In terms of improving the total effective rate, Shuxuetong injection (P-score = 0.69) was the most effective. In addition, Shuxuetong injection was most effective in lowering total cholesterol (P-score = 1.00) and triglyceride (P-score = 1.00) levels. Notably, Shuxuetong injection remained the most prominent in reducing fibrinogen (P-score = 0.91). However, among other blood hemorheology indicators, Dengzhanhuasu injection was the best regimen in reducing plasma viscosity (P-score = 1.00), whole blood viscosity (high shear rate) (P-score = 0.87), and whole blood viscosity (low shear rate) (P-score = 0.90). It was found that Yinxingyetiquwu injection (P-score = 0.72) was the most effective in reducing the incidence of cerebral infarction. In terms of safety, 22 studies reported adverse effects and descriptive analyses showed that the number of adverse effects of combination therapy was comparable to that of conventional therapy and that the safety profile was good.

Conclusions
TCM injections in combination with CT may be a safe and effective intervention for patients with TIA, of which Shuxuetong injection, Dengzhanhuasu injection, and Yinxingyetiquwu injection may be more noteworthy. The quality of the literature included in the study was low, so further validation is needed with larger sample sizes, higher quality, and more rigorously designed RCTs.

Systematic review registration
[PROSPERO], identifier [CRD42023443652].
Leisure-time physical activity improves happiness, health, and mood profile better than work-related physical activity
Authors: Skurvydas Albertas , Istomina Natalja , Dadeliene Ruta , Majauskiene Daiva , Strazdaite Emilija , Lisinskiene Ausra , Valanciene Dovile , Uspuriene Aiste Barbora , Sarkauskiene Asta 
Published: July 2024

Background
In an online survey of Lithuanian adults (n = 1140) aged 18 to 64 years, we sought to better understand the factors influencing the structure of physical activity (PA). We hypothesised that the PA paradox (i.e. the benefits of PA will be much greater during leisure-time than work-related or household moderate to vigorous PA) occurs more subjectively for psychological well-being indicators, than physiological well-being indicators, and should not depend on age or gender.

Methods
An online questionnaire was distributed as to potential participants through the Facebook social networking website within the period May 2021 to December 2021. PA was assessed using the long version of the International Physical Activity Questionnaire (IPAQ). Mood responses were assessed using the Brunel Mood Scale (BRUMS-LTU). Emotional intelligence was assessed using the Schutte Self-Report Emotional Intelligence Test (SSREIT). Perceived stress was assessed using the 10-item Perceived Stress Scale (PSS-10). Descriptive analysis, a two-way analysis of variance, and linear regression analysis were used to interpret the data.

Results
The results revealed that a PA paradox occurred in women and men in terms of health, happiness, vigour and perceived stress, and only in women according to morbidity and overeating. According to the regression analysis, women’s and men’s subjective health (β = 0.135; p < 0.001), happiness (β = 0.084; p = 0.018) and vigour (β = 0.169; p < 0.001) were significantly positively, and perceived stress (β = -0.088; p = 0.009) negatively correlated (regardless of age) only with leisure-time moderate to vigorous PA. ‘Healthy’, i.e. the amount of leisure-time PA in men decreases with age, while it does not change in women.

Conclusions
We believe that this study has expanded a clearer understanding of the PA paradox and its possible application to improving the health of individuals of different age groups.
222 nm causes greater protein damage and repair inhibition of E. coli than 254 nm for water disinfection
Authors: McDonald David , Ma Daniel , Hull Natalie M. 
Published: July 2024

Germicidal ultraviolet (UV) light has been widely used to inactivate pathogens in water. Emerging alternatives to conventional low pressure (LP) mercury lamps emitting at 254 nm, such as krypton chloride (KrCl) excimer lamps emitting at 222 nm, are gaining acceptance and popularity due to advantages in human safety and disinfection mechanisms. Cyclobutane pyrimidine dimer (CPD) formation kinetics and photolyase damage kinetics were quantified in E. coli for 222 nm and 254 nm UV. Molecular damage and cell regrowth were also quantified after UV irradiation under photorepair and dark repair incubation conditions using a standardized photorepair fluence response protocol. CPDs and photolyase were measured using enzyme linked immunosorbent assays (ELISA). A novel ELISA for photolyase was developed for this study. Culture-based log inactivation UV fluence responses were similar for 254 nm and 222 nm, with Geeraerd model estimates for rate constants of 1.18±0.09 and 1.24±0.08 cm2 mJ−1 for LP and KrCl lamps, respectively. Molecular UV fluence kinetics showed that the rate of CPD formation was greater by LP, but the rate of photolyase damage was greater by KrCl, as supported by the intercepts of repair kinetics. Compared to LP irradiated samples, KrCl irradiated samples exhibited less repair overall. For a given lamp, similar repair was observed between light and dark repair incubations. Percent reactivation rates with respect to photorepair fluence were (3.7±1.4)×10−5 and (–1.3±2.5)×10−5 cm2 mJ-1 for LP and KrCl lamps, respectively. CPDs decreased at a higher rate during repair incubations in LP samples than KrCl samples, and photolyase concentration increased in LP samples but decreased in KrCl samples. The results quantify contributions of photolyase protein damage to disinfection and repair prevention mechanism of KrCl lamps. This study mechanistically demonstrates why KrCl lamps can be applied for UV water disinfection to limit photorepair after treatment.
Synopsis: This study used a novel photolyase assay to demonstrate photolyase damage inflicted by krypton chloride excimer lamps contributes to disinfection of bacteria to prevent bacterial photorepair of damaged DNA and regrowth in drinking water treatment.
Dwelling in Active Serenity: Nature in Werner Herzog’s Cinema
Authors: Wu Haotian 
Published: July 2024

AbstractThis article puts Werner Herzog’s films in dialogue with Martin Heidegger’s philosophy to answer the question of how to dwell, to be at home with nature. I argue that an apathy–empathy aporia blockades the discussion of the nature–human relationship in Herzog’s cinema, which tends to view his representation of nature as either entirely apathetic to human flourishing or totally identifiable with being human. Both versions of nature fail to do full justice to the nuanced vision of nature in Herzog, especially its dynamics and problematics as a safe place. To address this problem, I will closely read and compare three of his films across his career: Aguirre, The Wrath Of God (1972), Grizzly Man (2005), and Happy People: A Year in the Taiga (2010) in the light of Heidegger’s philosophy. Drawing on Heidegger’s thought on dwelling, technology, being-in-the-world, temporality, Gelassenheit, and Care, I move away from the standard paradigm and reinterpret the nature–human relationship in Herzog as a negotiation between the homely and the unhomely in search of an equilibrium I call “active serenity.” Thus, this article is both a film-philosophy experiment with Herzog and Heidegger and a contemplation of the antagonism between humans and nature, which underlines our modern world.
Harnessing artificial intelligence for enhanced bioethanol productions: a cutting-edge approach towards sustainable energy solution
Authors: Damian Christopher Selvam , Devarajan Yuvarajan , Thandavamoorthy Raja , Jayabal Ravikumar 
Published: July 2024

Abstract
The adoption of biofuels as an energy source has experienced a substantial increase, exceeding the consumption of fossil fuels. The shift can be ascribed to the availability of renewable resources for energy production and the ecological advantages linked to their utilisation. Nevertheless, due to its intricate characteristics, the process of producing ethanol fuel from biomass poses difficulties in terms of administration, enhancement, and forecasting future results. To tackle these difficulties, it is crucial to utilise modelling techniques like artificial intelligence (AI) to create, oversee, and improve bioethanol production procedures. Artificial Neural Networks (ANN) is a prominent AI technique that offers significant advantages for modelling bioethanol production systems’ pretreatment, fermentation, and conversion stages. They are highly flexible and accurate, making them particularly well-suited. This study thoroughly examines several artificial intelligence techniques used in bioethanol production, specifically focusing on research published in the past ten years. The analysis emphasises the importance of using AI methods to address the complexities of bioethanol production and shows their role in enhancing efficiency and sustainability in the biofuel industry.
The crystal structure of the coordination compound catena-poly[(18-crown-6-ether-κ
6
O
6)(4,5-dinitroimidazolato-κ
1
O)potassium(I)]
Authors: Le Song , Lulu Liu , Jinfeng He , Dan He 
Published: July 2024

Abstract
C15H25KN4O10, monoclinic, P21 (no. 4), a = 8.3669(3) Å, b = 13.6610(4) Å, c = 9.6179(3) Å, β = 104.578(1)°, V = 1063.94(6) Å3, Z = 2, Rgt
(F) = 0.0391, wRref
(F
2) = 0.0863, T = 150 K.
Digoxin treatment does not reinduce radioiodine uptake in radioiodine refractory non-medullary thyroid carcinoma
Authors: van Houten Pepijn , Nagarajah James , Walraven Janneke E W , Jaeger Martin , van Engen-van Grunsven Adriana C H , Smit Johannes W , Netea-Maier Romana T 
Published: July 2024

Objective
Patients with non-medullary thyroid carcinoma (NMTC) that are refractory to radioactive iodine (RAI) have a poor prognosis. Strategies for restoring the ability to take up iodine, so-called redifferentiation, are promising but not suitable for all patients. Preclinical studies, in human cell lines just as in a murine model, have shown that the cardiac glycoside digoxin restored RAI uptake. This prospective single-center open-label study aimed to investigate whether treatment with digoxin could reinduce clinically relevant RAI uptake in patients with metastasized RAI-refractory NMTC.

Methods
Eight patients with metastasized RAI-refractory NMTC were included between November 2022 and June 2023. Before treatment, a baseline [123I]NaI scintigraphy was performed. Thereafter, patients were treated with digoxin for 3 weeks. Starting doses depended on age and weight. For safety reasons, the usual therapeutic range was aimed for. After 1 week, the digoxin plasma concentration was measured, and the digoxin dose was adjusted if necessary. After 3 weeks of digoxin treatment, a second [123I]NaI scintigraphy was performed. RAI uptake was compared between the two scintigraphies.

Results
Seven patients completed the digoxin treatment and were evaluable. None of the seven patients showed clinically relevant RAI uptake after digoxin treatment. No digoxin-related serious adverse events occurred during this trial.

Conclusion
Contrary to results from preclinical trials, in this trial, 3 weeks of digoxin treatment did not reinduce RAI uptake in patients with NMTC. This highlights essential challenges regarding the approach toward optimization of studies aimed to restore the RAI uptake and its therapeutic efficacy through drug repurposing.