bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geomorphological traits of landscapes in continental rifts—From fault‐elastic rebound to sedimentary sinks
Authors: Braathen Alvar , Midtkandal Ivar , Osmundsen Per Terje 
Published: July 2024

AbstractWe analyse 498 faults identified in satellite imagery and interpret the height and width of associated footwall ranges with respect to co‐seismic elastic rebound from tectonic and erosional unloading. The dynamics of footwall uplift link uplands to catchment patterns and interrelated hanging wall sedimentary fans. Height–length relations of some catchments and associated alluvial fans scale linearly whereas others, such as fault‐slope catchments and related down‐fault fans (building out from faults) show a significant scatter without an obvious trend. Perched basins abandoned in the footwalls of younger faults offer catchment‐fan height–length relations like watergap and dipslope‐related fans and, besides, hint at reduction of dip angle due to rollback of larger faults before abandonment. Analysis of the width‐to‐height ratio (W/h) of footwall ranges offer a robust linear statistical trend, h = 0.06 W and is identical between datasets. This trend is valid for both arid and tropical rifts, the latter offering smaller rebounds. Contributions of elastic rebound on fault throw in our data are simplistically considered through comparison to global trends on fault length versus throw. This allows consideration around maximum throw (Tmax) linked to the maximum height of footwall ranges (h) and to their width (W) above the reference level. Basic calculations indicate that co‐seismic rebound contributes from <1% to 17% of extensional fault throw. Width‐to‐height ratios for large faults (L > c. 50 km) show less spread than smaller faults. Such large faults expectedly dissect the brittle crust, indicating that these large faults which root in the ductile–brittle transition approach a balanced, steady‐state kinematic pattern. We speculate that significant crustal thinning associated with these large faults triggers the onset of isostatic adjustments that drive fault rotation, instigating fault abandonment and disconnected perched basins.
Prostate cancer cancer‐associated fibroblasts with stable markers post‐androgen deprivation therapy associated with tumor progression and castration resistant prostate cancer
Authors: Pan Shen , Yin Rui , Zhu Hehe , Shen Siang , Li Zhenhua , Liu Bitian 
Published: July 2024

AbstractThe specificity and clinical relevance of cancer‐associated fibroblasts (CAFs) in prostate cancer (PCa), as well as the effect of androgen deprivation therapy (ADT) on CAFs, remain to be fully elucidated. Using cell lineage diversity and weighted gene co‐expression network analysis (WGCNA), we pinpointed a unique CAF signature exclusive to PCa. The specificity of this CAF signature was validated through single‐cell RNA sequencing (scRNA‐seq), cell line RNA sequencing, and immunohistochemistry. This signature associates CAFs with tumor progression, elevated Gleason scores, and the emergence of castration resistant prostate cancer (CRPC). Using scRNA‐seq on collected samples, we demonstrated that the CAF‐specific signature is not altered by ADT, maintaining its peak signal output. Identifying a PCa‐specific CAF signature and observing signaling changes in CAFs after ADT lay essential groundwork for further PCa studies.
A hybrid evaluation of the intestinal absorption performance of compounds from molecular structure
Authors: Sheng Mengke , Ma Lina , Li Zhixun , Peng Xinhui , Cen Shuai , Feng Minfang , Tian Yuting , Dai Xingxing , Shi Xinyuan 
Published: July 2024

AbstractIntestinal absorption of compounds is significant in drug research and development. To evaluate this efficiently, a method combining mathematical modeling and molecular simulation was proposed, from the perspective of molecular structure. Based on the quantitative structure–property relationship study, the model between molecular structure and their apparent permeability coefficients was successfully constructed and verified, predicting intestinal absorption of drugs and interpreting decisive structural factors, such as AlogP98, Hydrogen bond donor and Ellipsoidal volume. The molecules with strong lipophilicity, less hydrogen bond donors and receptors, and small molecular volume are more easily absorbed. Then, the molecular dynamics simulation and molecular docking were utilized to study the mechanism of differences in intestinal absorption of drugs and investigate the role of molecular structure. Results indicated that molecules with strong lipophilicity and small volume interacted with the membrane at a lower energy and were easier to penetrate the membrane. Likewise, they had weaker interaction with P‐glycoprotein and were easier to escape from it and harder to export from the body. More in, less out, is the main reason these molecules absorb well.
Congenital three generation wide familial non‐syndromic polydactyly
Authors: Agdoğan Özgür 
Published: July 2024

AbstractPolydactyly is typically observed as isolated and sporadic occurrences, although familial cases do exist, albeit with lower frequency, manifesting in various inheritance patterns. In around 30% of polydactyly cases, there exists a familial history, suggesting the probable involvement of a single gene. Given its potential for hereditary transmission, thorough investigation of the patients' parents, first‐degree relatives, grandparents, and even great‐grandparents for similar disorders becomes imperative. In our clinic, we conducted an analysis focusing on patients presenting with foot polydactyly, along with occurrences of polydactyly among their first‐ and second‐degree relatives spanning two to three generations of family history. The study encompassed three patients and their respective families, including a pair of siblings. We speculate that the inheritance type in our cases was autosomal dominant. Among our patients, one presented with central polydactyly, while the remaining patients and all familial cases displayed postaxial polydactyly. In terms of morphologic classification, one patient had a Y‐shaped metatarsal, another had a T‐shaped metatarsal, and the third patient exhibited a duplicated ray‐shaped anomaly. In our review of the literature, we haven't come across a case spanning three generations like the ones we encountered. Additionally, the presence of a transverse accessory extensor tendon between both extensor tendons in cases with T‐ and Y‐shaped metatarsals intrigued us from an anatomical perspective. Our goal is to present these rare cases of congenital familial polydactyly spanning three generations, highlighting the anatomical variations observed and aiming to contribute to the existing body of literature on the subject.
Biogeographic patterns of Pacific white‐sided dolphins based on long‐term passive acoustic records
Authors: Alksne Michaela N. , Kok Annebelle C. M. , Agarwal Anika , Frasier Kaitlin E. , Baumann‐Pickering Simone 
Published: July 2024

AbstractAimThis study investigates the biogeographic patterns of Pacific white‐sided dolphins (Lagenorhynchus obliquidens) in the Eastern North Pacific based on long‐term passive acoustic records. We aim to elucidate the ecological and behavioural significance of distinct echolocation click types and their implications for population delineation, geographic distribution, environmental adaptation and management.LocationEastern North Pacific Ocean.Time Period2005–2021.Major Taxa StudiedPacific white‐sided dolphin.MethodsOver 50 cumulative years of passive acoustic monitoring (PAM) data from 14 locations were analyzed using a deep neural network to classify two distinct Pacific white‐sided dolphin echolocation click types. The study assessed spatial, diel, seasonal and interannual patterns of the two click types, correlating them with major environmental drivers such as the El Niño Southern Oscillation and the North Pacific Gyre Oscillation, and modeling long‐term spatial‐seasonal patterns.ResultsDistinct spatial, diel and seasonal patterns were observed for each click type. Significant biogeographical shifts in presence were observed following the 2014–2016 marine heatwave event.Main ConclusionsDistinct spatial distributions of the two click types support the hypothesis that Pacific white‐sided dolphins produce population‐specific echolocation clicks. Seasonal and diel patterns suggest spatiotemporal niche partitioning between the populations in Southern California. Interannual changes, notably initiated during the 2014–2016 marine heatwave, indicate climate‐driven range expansions and contractions related to gradual tropicalization of the Southern California Bight.
Zebrafish trpm7 mutants show reduced motility in free movement
Authors: Watai Kenta , Sadamitsu Kenichiro , Wada Seiji , Kashima Makoto , Hirata Hiromi 
Published: July 2024

AbstractParkinson's disease is a neurological disorder characterized by reduced motility, depression and dementia. Guamanian parkinsonism dementia with amyotrophic sclerosis is a local case of Parkinson's disease reported in the Western Pacific Islands of Guam and Rota as well as in the Kii Peninsula of Japan. A previous genetic study has suggested that Guamanian parkinsonism is attributable to a variant of the TRPM7 gene, which encodes for melastatin‐related transient receptor potential (TRP) ion channels. But the link between parkinsonism and the TRPM7 gene remains elusive. Previous studies have addressed that trpm7‐deficient zebrafish embryos showed defects in pigmentation and touch‐evoked motor response. In this study, we identified a new viable allele of trpm7 mutant causing an I756N amino acid substitution in the first transmembrane domain. Behavioral analyses revealed that trpm7 mutants showed compromised motility with their movement distance shorter than wild‐type larvae. The velocity of the movement was significantly reduced in trpm7 mutants than in wild‐type larvae. Along with a previous finding of reduced dopaminergic neurons in zebrafish trpm7 mutants, reduced motility of trpm7 mutants can suggest another similarity between trpm7 phenotypes and Parkinson's disease symptoms.
Do nest sites limit wild honey bee colonies? Decoding swarm waggle dances to assess nest site availability
Authors: Visick Oliver D. , Adams Idris , Ney Phoebe , Marzano Francesco S. , Ratnieks Francis L. W. 
Published: July 2024

Abstract
Nest sites are often considered to limit wild honey bee, Apis mellifera, colonies in Europe where wild colony densities are low (mean 0.26/km2). Nest site availability can be challenging to quantify directly, especially in urban areas and farmland where colonies nest in different substrates.
Here we assess nest site availability indirectly across large areas (78.5 km2) of mixed habitat (67% farmland, 25% urban and 8% woodland) by decoding 3310 waggle dances produced by scouts on swarms. During summers of 2021 and 2022, 14 artificial swarms were set up in two study areas in East Sussex, England.
Swarms advertised three to nine nest locations (mean of 5.5) at distances of 0.1–11.2 km (median 1.2 km) all within 0.4–15.2 daylight hours after dancing commenced (median 2.7). We estimated the total number of nest locations, including those not advertised, by quantifying the overlap in locations advertised by two swarms (a form of mark–recapture), which gave a mean density of approximately three nest sites per km2.
The probability of swarms advertising nest sites per km2, calculated using simulations of dance variation, was an average of 42% higher in urban areas (0.018/km2), 78% higher in woodland (0.023/km2) and 12% lower in farmland (0.011/km2) than random expectation. After controlling for distance, swarms were still more likely than expected to advertise nest sites in woodland but only in one study area.
Our results indicate that nest sites do not limit wild colonies in the study areas given that our conservative estimate of nest site density (3/km2) exceeds the density of wild colonies on nearby landed estates (2/km2) and other locations in Europe (0.26/km2).
Young Spouses' Experiences of Having a Partner With Heart Disease and Adolescents Living at Home
Authors: Holmbom Matilda , Andréasson Frida , Grundström Hanna , Bernild Camilla , Fålun Nina , Norekvål Tone Merete , Kikkenborg Berg Selina , Strömberg Anna 
Published: July 2024

ABSTRACTAimTo describe the life situation of spouses having a partner with heart disease and adolescents living at home.DesignQualitative inductive design.MethodParticipants (n = 22) were included from three Scandinavian countries. Semi‐structured interviews were analysed using thematic analysis with an inductive and latent approach.ResultsThree themes were derived. ‘Being in spousal and parental role transition’ described how daily life had been affected and parental responsibilities had been doubled due to their partner's heart disease. ‘Living with unpredictability and insecurity’ included how the unpredictable illness trajectory caused worries and affected the well‐being of the family. ‘Managing a challenging life situation’ highlights how spouses coped with their partners' heart disease and adapted to a new life situation.ConclusionYoung spouses' life situation was greatly affected by their partner's heart disease, resulting in increased responsibilities and double parenthood. Having a positive attitude and mindset towards life was used as a strategy to cope with the changed life situation and find a new way of life.Implications for the Profession and/or Patient CareAll family members are affected by heart disease. Spouses needed additional professional support and guidance on how to involve the children when a parent is ill.Impacts

This study highlights how young spouses, with adolescents living at home, experience their life situation.
The life situation is unpredictable due to the partner's heart disease, as they must handle both caring for their partner and taking on double parenthood.
Research involving family members can improve person‐ and family‐centred care and treatment outcomes in health care and society.Reporting MethodCOREQ checklist was used preparing the manuscript.Patient or Public ContributionData collection included interviews with spouse.What Does This Paper Contribute to the Wider Global Clinical Community?By highlighting the spouses changed life situation due to heart disease and the importance of including them in health care.
The role of changing landscape in the dispersal of a soil‐feeding termite in Suriname and French Guiana
Authors: Gergonne Damien , Poteaux Chantal , Fourcade Yoan , Fougeyrollas Romain , Hanus Robert , Sillam‐Dussès David , Roy Virginie 
Published: July 2024

Abstract
Neotropical forest ecosystems harbour significant biodiversity. To develop effective insect conservation practices, it is important to understand the factors that influence the diversity and population structure of the species.
Dispersal, a key determinant of population structure, is well studied in termites nesting in wood, for which it can be influenced by wood transport, or in termites living in urban environments. However, understanding the dispersal of termites whose mobility remains unaffected by wood transport remains understudied.
We investigated the dispersal of Embiratermes neotenicus, a soil‐feeding species with short dispersal distance, in the Neotropical region, where both intact and degraded forests exist. Using mitochondrial and nuclear data, we analysed genetic diversity, structure and factors contributing to population differentiation in Suriname and French Guiana at multiple scales for 70 colonies.
The population in French Guiana is the ancestral population in the region that subsequently expanded.
Significant genetic differentiation between populations was observed, with distinct patterns identified in Suriname and French Guiana. The Suriname population showed higher genetic diversity and no subpopulation differentiation, whereas the French Guiana population showed substructure into distinct genetic clusters.
Analyses at the scale of all colonies suggest the influence of landscape features, such as the Maroni River, on genetic differentiation. At the local scale, genetic differentiation between colonies increases with forest alteration, even when this does not include major changes in forest cover.
Our results highlight the sensitivity of soil‐feeding termite populations to habitat change. We argue that multi‐scale studies are needed for a comprehensive understanding of genetic patterns, especially for species with short dispersal distances.
Preservation of the native urethral plate and corpus spongiosum combined with buccal mucosa graft plus Orandi's penile skin flap as an alternative to staged urethroplasty for narrow penile strictures
Authors: Karapanos Leonidas , Halbe Luisa , Storz Enno , Rieger Constantin , Weiten Richard , Ergashev Bobirjon , Heidenreich Axel 
Published: July 2024

ObjectiveIn narrow anterior urethral strictures, the combined buccal mucosa graft (BMG) with pedicled penile skin flap (PSF) represents a well‐known effective alternative to staged urethroplasty. We hypothesized that if the native urethral plate and adjacent corpus spongiosum were preserved, a narrower flap would be needed, and reinforced ventral stability could be achieved without compromising the surgical outcome.MethodsTwelve patients with narrow penile urethral strictures underwent single‐stage augmentation urethroplasty using a combined technique. A BMG was quilted to the corpora cavernosa in a dorsal onlay approach, and a longitudinal ventral PSF was transposed ventrally and sutured to the scarred native urethral mucosa on one side and to the BMG on the other side to form a neourethra of triangular form. The preserved corpus spongiosum was wrapped and fixed around the flap ventrally.ResultsThe median age was 47 years (IQR 35–59), and the median stricture length was 5 cm (IQR 3, 8–7). The median surgical time was 205 min (IQR 172–236). The overall success rate (SR) was 91.7% without sacculation or diverticula formation after a median follow‐up period of 38 months (IQR 33–40). Three transient fistulas healed through prolonged urinary diversion. Five patients (41.7%) reported postvoid dribbling following urethroplasty.ConclusionPreservation of the native urethral plate is a valuable adjunct to the combination of graft and flap for single‐stage augmentation urethroplasty for narrow urethral strictures, with satisfactory mid‐term success and an acceptable complication rate.
Validation of the area under the Watts factor curve during the voiding cycle as a novel parameter for diagnosing detrusor underactivity in females
Authors: Kitta Takeya , Wada Naoki , Shinohara Satoshi , Hayashi Nagisa , Yamamura Hayato , Yamamoto Takayuki , Takagi Haruka , Hatakeyama Tsubasa , Nagabuchi Masaya , Morishita Shun , Tsunekawa Ryouken , Ohtani Miyu , Kobayashi Shin , Hori Jun‐ichi , Kakizaki Hidehiro 
Published: July 2024

ObjectiveDetrusor underactivity (DU) is a common cause of lower urinary tract symptoms (LUTS). To date, no consensus has been reached on the urodynamic criteria for defining DU. We previously proposed the area under the curve of the Watts factor (WF‐AUC) as a new parameter for diagnosing DU. By comparing previously reported five criteria for DU and WF‐AUC, we analyzed whether the WF‐AUC could assess detrusor contraction in women with LUTS.MethodsUsing urodynamic data of consecutive 77 women with LUTS, first, we classified DU based on previously reported five criteria. Second, we assessed the potential correlation between multiple parameters and WF‐AUC. Third, receiver operating characteristic curve analysis was performed to determine the cutoff value of WF‐AUC for diagnosing DU based on previously reported five criteria. Fourth, a linear regression analysis was conducted and compared using multiple criteria and female bladder outlet obstruction index (BOOIf).ResultsWF‐AUC was positively correlated with the maximum values of WF, bladder contractility index (BCI), and projected isovolumetric pressure 1 (PIP1) with correlation coefficients of 0.63, 0.57, and 0.34, respectively. AUC for diagnosing DU based on previously reported five criteria ranging from 0.773 to 0.896 with different cutoff values of AUC‐WF. The Spearman's correlation test revealed that BOOIf was significantly correlated with BCI, but not Wmax, PIP1 and WF‐AUC.ConclusionsThis study demonstrated the non‐inferiority of the WF‐AUC compared to previously reported criteria for defining DU. Depending on the cutoff value, the WF‐AUC could appropriately evaluate women with DU, regardless of the presence of BOO.
Survival of stage III non‐seminoma testis cancer patients versus simulated controls, according to race/ethnicity
Authors: Morra Simone , Cano Garcia Cristina , Piccinelli Mattia Luca , Tappero Stefano , Barletta Francesco , Incesu Reha‐Baris , Scheipner Lukas , Baudo Andrea , Tian Zhe , de Angelis Mario , Mirone Vincenzo , Califano Gianluigi , Celentano Giuseppe , Saad Fred , Shariat Shahrokh F. , Chun Felix K. H. , de Cobelli Ottavio , Musi Gennaro , Terrone Carlo , Briganti Alberto , Tilki Derya , Ahyai Sascha , Carmignani Luca , Longo Nicola , Karakiewicz Pierre I. 
Published: July 2024

BackgroundIt is unknown whether 5‐year overall survival (OS) differs and to what extent between the American Joint Committee on Cancer stage III non‐seminoma testicular germ cell tumor (NS‐TGCT) patients and simulated age‐matched male population‐based controls, according to race/ethnicity groups.MethodsWe identified newly diagnosed (2004–2014) stage III NS‐TGCT patients within the Surveillance Epidemiology and End Results database 2004–2019. For each case, we simulated an age‐matched male control (Monte Carlo simulation), relying on Social Security Administration (SSA) Life Tables with 5 years of follow‐up. We compared OS rates between stage III NS‐TGCT patients and simulated age‐matched male population‐based controls, according to race/ethnicity groups (Caucasian, Hispanic, Asian/Pacific Islander and African American). Both, cancer‐specific mortality (CSM) and other‐cause mortality (OCM) were computed.ResultsOf 2054 stage III NS‐TGCT patients, 60% were Caucasians versus 33% Hispanics versus 4% Asians/Pacific Islanders versus 3% African Americans. The 5‐year OS difference between stage III NS‐TGCT patients versus simulated age‐matched male population‐based controls was highest in Asians/Pacific Islanders (64 vs. 99%, Δ = 35%), followed by African Americans (66 vs. 97%, Δ = 31%), Hispanics (72 vs. 99%, Δ = 27%), and Caucasians (76 vs. 98%, Δ = 22%). The 5‐year CSM rate was highest in Asians/Pacific Islanders (32%), followed by African Americans (26%), Hispanics (25%), and Caucasians (20%). The 5‐year OCM rate was highest in African Americans (8%), followed by Caucasians (4%), Asians/Pacific Islanders (4%), and Hispanics (2%).ConclusionRelative to SSA Life Tables, the highest 5‐year OS disadvantage applied to stage III NS‐TGCT Asian/Pacific Islander race/ethnicity group, followed by African American, Hispanic and Caucasian, in that order.