bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interpretability of doctor identification badges in UK hospitals: a survey of nurses and patients
Authors: Hickerton Bethan C , Fitzgerald Daniel John , Perry Elizabeth , De Bolla Alan R 
Published: March 2014

IntroductionHospital badges have multiple important purposes, but their essential role remains the clear identification of the bearer, including their professional status. The modernisation of medical careers in the National Health Service has changed terminology dramatically, resulting in a plethora of new job titles emerging among both doctors and nurses.ObjectiveTo determine whether the new or old terminology allowed clearer identification of medical doctors by patients and nurses.MethodWe replicated 11 identification badges used in the Royal Cornwall Hospital and Wrexham Maelor Hospital, both current and before the introduction of new medical training terminology. Data were collected from 114 patients and 67 nurses, by asking them to (1) identify which name badges represented doctors and (2) rank them in order of seniority.ResultsOnly 11% of patients and 60% of nurses identified a ‘Foundation Year 1 Trainee’ as a qualified medical doctor. Indeed, only ‘General Practice Vocational Trainee’ and ‘Consultant’ were both readily identifiable as qualified doctors to both patients and nurses. Ranking was also a problem, with only 19% of patients and 45% of nurses able to correctly grade medical doctors using the current terminology.The old terminology allowed more accurate identification by nurses, with over 80% successfully ranking and marking the title appropriately.ConclusionsCurrent terminology is a source of confusion to both patients and members of the immediate medical care team, with nurses unable to correctly identify medical doctors. Our study indicates that a review of terminology is necessary to ensure patients, and staff, are able to communicate effectively.
Endothelial-Specific Notch Blockade Inhibits Vascular Function and Tumor Growth through an eNOS-Dependent Mechanism
Authors: Patenaude Alexandre , Fuller Megan , Chang Linda , Wong Fred , Paliouras Grigorios , Shaw Rebecca , Kyle Alastair H. , Umlandt Patricia , Baker Jennifer H.E. , Diaz Erika , Tong Jade , Minchinton Andrew I. , Karsan Aly 
Published: March 2014

Abstract
Notch signaling is important for tumor angiogenesis induced by vascular endothelial growth factor A. Blockade of the Notch ligand Dll4 inhibits tumor growth in a paradoxical way. Dll4 inhibition increases endothelial cell sprouting, but vessels show reduced perfusion. The reason for this lack of perfusion is not currently understood. Here we report that inhibition of Notch signaling in endothelial cell using an inducible binary transgenic system limits VEGFA-driven tumor growth and causes endothelial dysfunction. Neither excessive endothelial cell sprouting nor defects of pericyte abundance accompanied the inhibition of tumor growth and functional vasculature. However, biochemical and functional analysis revealed that endothelial nitric oxide production is decreased by Notch inhibition. Treatment with the soluble guanylate cyclase activator BAY41-2272, a vasorelaxing agent that acts downstream of endothelial nitric oxide synthase (eNOS) by directly activating its soluble guanylyl cyclase receptor, rescued blood vessel function and tumor growth. We show that reduction in nitric oxide signaling is an early alteration induced by Notch inhibition and suggest that lack of functional vessels observed with Notch inhibition is secondary to inhibition of nitric oxide signaling. Coculture and tumor growth assays reveal that Notch-mediated nitric oxide production in endothelial cell requires VEGFA signaling. Together, our data support that eNOS inhibition is responsible for the tumor growth and vascular function defects induced by endothelial Notch inhibition. This study uncovers a novel mechanism of nitric oxide production in endothelial cells in tumors, with implications for understanding the peculiar character of tumor blood vessels. Cancer Res; 74(9); 2402–11. ©2014 AACR.
Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
Authors: Fiskus Warren , Saba Nakhle , Shen Min , Ghias Mondana , Liu Jinyun , Gupta Soumyasri Das , Chauhan Lata , Rao Rekha , Gunewardena Sumedha , Schorno Kevin , Austin Christopher P. , Maddocks Kami , Byrd John , Melnick Ari , Huang Peng , Wiestner Adrian , Bhalla Kapil N. 
Published: March 2014

AbstractChronic lymphocytic leukemia (CLL) exhibits high remission rates after initial chemoimmunotherapy, but with relapses with treatment, refractory disease is the most common outcome, especially in CLL with the deletion of chromosome 11q or 17p. In addressing the need of treatments for relapsed disease, we report the identification of an existing U.S. Food and Drug Administration-approved small-molecule drug to repurpose for CLL treatment. Auranofin (Ridaura) is approved for use in treating rheumatoid arthritis, but it exhibited preclinical efficacy in CLL cells. By inhibiting thioredoxin reductase activity and increasing intracellular reactive oxygen species levels, auranofin induced a lethal endoplasmic reticulum stress response in cultured and primary CLL cells. In addition, auranofin displayed synergistic lethality with heme oxygenase-1 and glutamate-cysteine ligase inhibitors against CLL cells. Auranofin overcame apoptosis resistance mediated by protective stromal cells, and it also killed primary CLL cells with deletion of chromosome 11q or 17p. In TCL-1 transgenic mice, an in vivo model of CLL, auranofin treatment markedly reduced tumor cell burden and improved mouse survival. Our results provide a rationale to reposition the approved drug auranofin for clinical evaluation in the therapy of CLL. Cancer Res; 74(9); 2520–32. ©2014 AACR.
Accelerating Translation of Physical Activity and Cancer Survivorship Research into Practice: Recommendations for a More Integrated and Collaborative Approach
Authors: Phillips Siobhan M. , Alfano Catherine M. , Perna Frank M. , Glasgow Russell E. 
Published: March 2014

Abstract
Physical activity has been deemed safe and effective in reducing many negative side effects of treatment for cancer survivors and promoting better overall health. However, most of this research has focused on highly controlled randomized trials and little of this research has been translated into care or policy for survivors. The purpose of the present article is to present a research agenda for the field to accelerate the dissemination and implementation of empirically supported physical activity interventions into care. We provide rationale for the role of basic, behavioral, clinical implementation, and population scientists in moving this science forward and call for a more coordinated effort across different phases of research. In addition, we provide key strategies and examples for ongoing and future studies using the RE-AIM (reach, efficacy/effectiveness, adoption, implementation, and maintenance) framework and pose recommendations for collaborations between researchers and stakeholders to enhance the integration of this research into policy and practice. Overall, we recommend that physical activity and cancer survivorship research use additional study designs, include relevant stakeholders, and be more collaborative, integrated, contextual, and representative in terms of both setting and participants. Cancer Epidemiol Biomarkers Prev; 23(5); 687–99. ©2014 AACR.
Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel
Authors: Abraham Jean E. , Guo Qi , Dorling Leila , Tyrer Jonathan , Ingle Susan , Hardy Richard , Vallier Anne-Laure , Hiller Louise , Burns Russell , Jones Linda , Bowden Sarah J. , Dunn Janet A. , Poole Christopher J. , Caldas Carlos , Pharoah Paul P.D. , Earl Helena M. 
Published: March 2014

Abstract
Purpose: Associations between taxane-related sensory neuropathy (TRSN) and single-nucleotide polymorphisms (SNP) have previously been reported, but few have been replicated in large, independent validation studies. This study evaluates the association between previously investigated SNPs and TRSN, using genotype data from a study of chemotherapy-related toxicity in patients with breast cancer.
Experimental Design: We investigated 73 SNPs in 50 genes for their contribution to TRSN risk, using genotype data from 1,303 European patients. TRSN was assessed using National Cancer Institute common toxicity criteria for adverse events classification. Unconditional logistic regression evaluated the association between each SNP and TRSN risk (primary analysis). Cox regression analysis assessed the association between each SNP and cumulative taxane dose causing the first reported moderate/severe TRSN (secondary analysis). The admixture likelihood (AML) test, which considers all SNPs with a prior probability of association with TRSN together, tested the hypothesis that certain SNPs are truly associated.
Results: The AML test provided strong evidence for the association of some SNPs with TRSN (P = 0.023). The two most significantly associated SNPs were rs3213619(ABCB1) [OR = 0.47; 95% confidence interval (CI), 0.28–0.79; P = 0.004] and rs9501929(TUBB2A) (OR = 1.80; 95% CI, 1.20–2.72; P = 0.005). A further 9 SNPs were significant at P-value ≤ 0.05.
Conclusion: This is currently the largest study investigating SNPs associated with TRSN. We found strong evidence that SNPs within genes in taxane pharmacokinetic and pharmacodynamic pathways contribute to TRSN risk. However, a large proportion of the inter-individual variability in TRSN remains unexplained. Further validated results from GWAS will help to identify new pathways, genes, and SNPs involved in TRSN susceptibility. Clin Cancer Res; 20(9); 2466–75. ©2014 AACR.
The Public Diplomacy of Federated Entities: Examining the Quebec Model
Authors: Huijgh Ellen 
Published: March 2014

Calls to involve a wide range of actors in public diplomacy are coming thick and fast. Federated entities are waiting in line, hoping to advance their international influence and search for distinctiveness and self-affirmation. Despite the increasing interest the development of most federated entities’ public diplomacy has not yet moved out of the early phases: a borderline activity of ‘nation-branding’ and ‘paradiplomacy’. This is true not only in practice but also in the current research, a situation that this article aims to amend.
To this end, it is not necessary to start anew but to expand upon more advanced cases in the field. Particular interest is given to Quebec, which is busy creating a distinct profile for public diplomacy and alluding to a more normatively inspired network model. This article examines the public diplomacy model of Quebec’s ministry of international relations, and interprets the findings for federated entities in light of new evolutions in the field. The article concludes that despite significant discourse on public diplomacy development, major reforms remain in the realm of theory.
Scorpion venoms as a potential source of novel cancer therapeutic compounds
Authors: Ding Jian , Chua Pei-Jou , Bay Boon-Huat , Gopalakrishnakone P 
Published: March 2014

Scorpions and their venoms have been used in traditional medicine for thousands of years in China, India and Africa. The scorpion venom is a highly complex mixture of salts, nucleotides, biogenic amines, enzymes, mucoproteins, as well as peptides and proteins (e.g. neurotoxins). One of the recently observed biological properties of animal venoms and toxins is that they possess anticancer potential. An increasing number of studies have shown that scorpion venoms and toxins can decrease cancer growth, induce apoptosis and inhibit cancer progression and metastasis in vitro and in vivo. Several active molecules with anticancer activities, ranging from inhibition of proliferation and cell cycle arrest to induction of apoptosis and decreasing cell migration and invasion, have been isolated from scorpion venoms. These observations have shed light on the application of scorpion venoms and toxins as potential novel cancer therapeutics. This mini-review focuses on the anticancer potential of scorpion venoms and toxins and the possible mechanisms for their antitumor activities.
Autocrine inhibition of the c-fms proto-oncogene reduces breast cancer bone metastasis assessed with in vivo dual-modality imaging
Authors: Jeffery Justin J , Lux Katie , Vogel John S , Herrera Wynetta D , Greco Stephen , Woo Ho-Hyung , AbuShahin Nisreen , Pagel Mark D , Chambers Setsuko K 
Published: March 2014

Breast cancer cells preferentially home to the bone microenvironment, which provides a unique niche with a network of multiple bidirectional communications between host and tumor, promoting survival and growth of bone metastases. In the bone microenvironment, the c-fms proto-oncogene that encodes for the CSF-1 receptor, along with CSF-1, serves as one critical cytokine/receptor pair, functioning in paracrine and autocrine fashion. Previous studies concentrated on the effect of inhibition of host (mouse) c-fms on bone metastasis, with resulting decrease in osteolysis and bone metastases as a paracrine effect. In this report, we assessed the role of c-fms inhibition within the tumor cells (autocrine effect) in the early establishment of breast cancer cells in bone and the effects of this early c-fms inhibition on subsequent bone metastases and destruction. This study exploited a multidisciplinary approach by employing two non-invasive, in vivo imaging methods to assess the progression of bone metastases and bone destruction, in addition to ex vivo analyses using RT-PCR and histopathology. Using a mouse model of bone homing human breast cancer cells, we showed that an early one-time application of anti-human c-fms antibody delayed growth of bone metastases and bone destruction for at least 31 days as quantitatively measured by bioluminescence imaging and computed tomography, compared to controls. Thus, neutralizing human c-fms in the breast cancer cell alone decreases extent of subsequent bone metastasis formation and osteolysis. Furthermore, we are the first to show that anti-c-fms antibodies can impact early establishment of breast cancer cells in bone.
Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells
Authors: Park Ji-Won , Kim Seung Cheol , Kim Won Ki , Hong Jun Pyu , Kim Kyung-Hee , Yeo Hyun Yang , Lee Jae Yong , Kim M Sun , Kim Jong Heon , Yang Se Young , Kim Dae Yong , Oh Jae Hwan , Cho Jae Youl , Yoo Byong Chul 
Published: March 2014

AbstractBackgroundResistance to 5-fluorouracil (5-FU) in patients with colorectal cancer prevents effective treatment and leads to unnecessary and burdensome chemotherapy. Therefore, prediction of 5-FU resistance is imperative.MethodsTo identify the proteins linked to 5-FU resistance, two-dimensional gel electrophoresis-based proteomics was performed using the human colon cancer cell line SNU-C4R with induced 5-FU resistance. Proteins showing altered expression in SNU-C4R were identified by matrix-associated laser desorption/ionization–time-of-flight analysis, and their roles in susceptibility to 5-FU or radiation were evaluated in various cell lines by transfection of specific siRNA or creation of overexpression constructs. Changes in cellular signaling and expression of mitochondrial apoptotic factors were investigated by Western Blot analysis. A mitochondrial membrane potential probe (JC-1 dye) and a flow cytometry system were employed to determine the mitochondrial membrane potential. Finally, protein levels were determined by Western Blot analysis in tissues from 122 patients with rectal cancer to clarify whether each identified protein is a useful predictor of a chemoradiation response.ResultsWe identified mitochondrial phosphoenolpyruvate carboxykinase (mPEPCK) as a candidate predictor of 5-FU resistance. PEPCK was downregulated in SNU-C4R compared with its parent cell line SNU-C4. Overexpression of mPEPCK did not significantly alter the susceptibility to either 5-FU or radiation. Suppression of mPEPCK led to a decrease in both the cellular level of phosphoenolpyruvate and the susceptibility to 5-FU and radiation. Furthermore, the cellular levels of phosphoenolpyruvate (an end product of PEPCK and a substrate of pyruvate kinase), phosphorylated AKT, and phosphorylated 4EBP1 were decreased significantly secondary to the mPEPCK suppression in SNU-C4. However, mPEPCK siRNA transfection induced changes in neither the mitochondrial membrane potential nor the expression levels of mitochondrial apoptotic factors such as Bax, Bcl-2, and Bad. Downregulation of total PEPCK was observed in tissues from patients with rectal cancer who displayed poor responses to preoperative 5-FU-based radiation therapy.ConclusionOur overall results demonstrate that mPEPCK is a useful predictor of a response to chemoradiotherapy in patients with rectal cancer.
Speech pathologists’ experiences with stroke clinical practice guidelines and the barriers and facilitators influencing their use: a national descriptive study
Authors: Hadely Kathleen A , Power Emma , O’Halloran Robyn 
Published: March 2014

Abstract

Background
Communication and swallowing disorders are a common consequence of stroke. Clinical practice guidelines (CPGs) have been created to assist health professionals to put research evidence into clinical practice and can improve stroke care outcomes. However, CPGs are often not successfully implemented in clinical practice and research is needed to explore the factors that influence speech pathologists’ implementation of stroke CPGs. This study aimed to describe speech pathologists’ experiences and current use of guidelines, and to identify what factors influence speech pathologists’ implementation of stroke CPGs.

Methods
Speech pathologists working in stroke rehabilitation who had used a stroke CPG were invited to complete a 39-item online survey. Content analysis and descriptive and inferential statistics were used to analyse the data.

Results
320 participants from all states and territories of Australia were surveyed. Almost all speech pathologists had used a stroke CPG and had found the guideline “somewhat useful” or “very useful”. Factors that speech pathologists perceived influenced CPG implementation included the: (a) guideline itself, (b) work environment, (c) aspects related to the speech pathologist themselves, (d) patient characteristics, and (e) types of implementation strategies provided.

Conclusions
There are many different factors that can influence speech pathologists’ implementation of CPGs. The factors that influenced the implementation of CPGs can be understood in terms of knowledge creation and implementation frameworks. Speech pathologists should continue to adapt the stroke CPG to their local work environment and evaluate their use. To enhance guideline implementation, they may benefit from a combination of educational meetings and resources, outreach visits, support from senior colleagues, and audit and feedback strategies.
Findings on ranking evaluation functions for feature weighting in image retrieval
Authors: da Silva Sergio F , Avalhais Letricia PS , Batista Marcos A , Barcelos Celia AZ , Traina Agma JM 
Published: March 2014

Abstract

Background
There are substantial benefits to be gained from ranking optimization in several information retrieval and recommendation systems. However, the analysis of ranking evaluation functions (REFs), which play a major role in many ranking optimization models, needs to be further investigated. An analysis of previous studies that investigated REFs was performed, and evidence was found which indicated that the choice of a proper REF is context sensitive.

Methods
In this study, we analyze a broad set of REFs for feature weighting aimed at increasing the image retrieval effectiveness. The REFs analyzed sums ten and includes the most successful and representative REFs from the literature. The REFs were embedded into a genetic algorithm (GA)-based relevance feedback (RF) model, called WLSP-C ±, aimed at improving image retrieval results through the use of learning weights for image descriptors and image regions.

Results
Analyses of precision-recall curves in five real-world image data sets showed that one non-parameterized REF named F5, not analyzed in previous studies, overcame recommended ones, which require parameter adjustment. We also provided a computational analysis of the GA-based RF model investigated, and it was shown that it is linear in regard to the image data set cardinality.

Conclusions
We conclude that REF F5 should be investigated in other contexts and problem scenarios centered on ranking optimization, as ranking optimization techniques rely heavily on the ranking quality measure.
Association of Zinc, Copper and Magnesium with bone mineral density in Iranian postmenopausal women – a case control study
Authors: Razmandeh Rezvan , Nasli-Esfahani Ensieh , Heydarpour Reza , Faridbod Farnoush , Ganjali Mohammad Reza , Norouzi Parviz , Larijani Bagher , Khoda-amorzideh Davood 
Published: March 2014

AbstractBackgroundThe risk of inadequate nutrition such as trace elements and vitamin deficiencies is considerable in postmenopausal women. The aim of this study was to compare trace elements (Zinc, Copper and Magnesium) concentration in nail, urine and serum among osteoporotic postmenopausal women with control group in Iran.MethodsForty eight postmenopausal women aged 36–60 years, were recruited, consisting 30 osteoporotic patients and 18 healthy controls. Blood, nail and urine concentration of Zinc (Zn), copper (Cu) and magnesium (Mg) were determined using Inductively Coupled Plasma -Atomic Emission Spectrometry (ICP-AES) method. Their Bone Mineral Density was measured by Dual X-ray Absorption (DEXA) method.ResultsThe urine level of trace elements had significant difference between osteoporotic groups and controls (p < 0.001). Moreover Mg level significantly differed in serum between two groups (p < 0.04). There was no statistically significant difference in trace minerals in nail beyond groups.ConclusionOur findings indicate that Urine Zn level could be considerable an appropriate marker for bone absorption, usage of Zn supplements in postmenopausal women may result a beneficial reduction in osteoporotic risk.