bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic screening of buildings based on the 2010 National Building Code of Canada
Authors: Saatcioglu M. , Shooshtari M. , Foo S. 
Published: April 2013

Seismic screening software is developed for existing buildings in Canada on the basis of the requirements of 2010 National Building Code of Canada. The software is based on the “Manual for Screening of Buildings for Seismic Investigation,” published by the National Research Council of Canada in 1992. The new software incorporates updated seismicity and soil classifications used in the National Building Code of Canada (NBCC) since 2005, as well as the new ductility and over-strength factors specified in the 2010 NBCC. The uniform hazard spectrum values of the current Canadian seismicity, defined for each municipality in Canada with a 2500 year earthquake return period, are used as reference hazard values. Seismic risk associated with the use of older seismic hazard values specified in older editions of the NBCC is identified relative to the current reference seismicity. The new site classifications are incorporated, while establishing relative soil amplification values between the new acceleration-based and velocity-based soil amplification factors and the foundation factors used in older codes. The new ductility and over-strength factors used in recent editions of the code are introduced in identifying different structural types with different toughness and energy dissipation capacities. The software can be used to conduct seismic screening of buildings located in different municipalities in Canada relative to the seismic requirements of NBCC-2010. It can also be used to generate tables for different locations in the country for manual screening of buildings.
Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases
Authors: Riese Matthew J. , Wang Liang-Chuan S. , Moon Edmund K. , Joshi Rohan P. , Ranganathan Anjana , June Carl H. , Koretzky Gary A. , Albelda Steven M. 
Published: April 2013

Abstract
Recent clinical trials have shown promise in the use of chimeric antigen receptor (CAR)-transduced T cells; however, augmentation of their activity may broaden their clinical use and improve their efficacy. We hypothesized that because CAR action requires proteins essential for T-cell receptor (TCR) signal transduction, deletion of negative regulators of these signaling pathways would enhance CAR signaling and effector T-cell function. We tested CAR activity and function in T cells that lacked one or both isoforms of diacylglycerol kinase (dgk) expressed highly in T cells, dgkα and dgkζ, enzymes that metabolize the second messenger diacylglycerol (DAG) and limit Ras/ERK activation. We found that primary murine T cells transduced with CARs specific for the human tumor antigen mesothelin showed greatly enhanced cytokine production and cytotoxicity when cocultured with a murine mesothelioma line that stably expresses mesothelin. In addition, we found that dgk-deficient CAR-transduced T cells were more effective in limiting the growth of implanted tumors, both concurrent with and after establishment of tumor. Consistent with our studies in mice, pharmacologic inhibition of dgks also augments function of primary human T cells transduced with CARs. These results suggest that deletion of negative regulators of TCR signaling enhances the activity and function of CAR-expressing T cells and identify dgks as potential targets for improving the clinical potential of CARs. Cancer Res; 73(12); 3566–77. ©2013 AACR.
Pak1 Kinase Links ErbB2 to β-Catenin in Transformation of Breast Epithelial Cells
Authors: Arias-Romero Luis E. , Villamar-Cruz Olga , Huang Min , Hoeflich Klaus P. , Chernoff Jonathan 
Published: April 2013

Abstract
p21-Activated kinase-1 (Pak1) is frequently upregulated in human breast cancer and is required for transformation of mammary epithelial cells by ErbB2. Here, we show that loss of Pak1, but not the closely related Pak2, leads to diminished expression of β-catenin and its target genes. In MMTV-ErbB2 transgenic mice, loss of Pak1 prolonged survival, and mammary tissues of such mice showed loss of β-catenin. Expression of a β-catenin mutant bearing a phospho-mimetic mutation at Ser 675, a specific Pak1 phosphorylation site, restored transformation to ErbB2-positive, Pak1-deficient mammary epithelial cells. Mice bearing xenografts of ErbB2-positive breast cancer cells showed tumor regression when treated with small-molecule inhibitors of Pak or β-catenin, and combined inhibition by both agents was synergistic. These data delineate a signaling pathway from ErbB2 to Pak to β-catenin that is required for efficient transformation of mammary epithelial cells, and suggest new therapeutic strategies in ErbB2-positive breast cancer. Cancer Res; 73(12); 3671–82. ©2013 AACR.
Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
Authors: Jimeno Antonio , Weiss Glen J. , Miller Wilson H. , Gettinger Scott , Eigl Bernard J.C. , Chang Anne Lynne S. , Dunbar Joi , Devens Shannon , Faia Kerrie , Skliris Georgios , Kutok Jeff , Lewis Karl D. , Tibes Raoul , Sharfman William H. , Ross Robert W. , Rudin Charles M. 
Published: April 2013

Abstract
Purpose: To conduct a first-in-human phase I study to determine the dose-limiting toxicities (DLT), characterize the pharmacokinetic profile, and document the antitumor activity of IPI-926, a new chemical entity that inhibits the Hedgehog pathway (HhP).
Experimental Design: Patients with solid tumors refractory to standard therapy were given IPI-926 once daily (QD) by mouth in 28-day cycles. The starting dose was 20 mg, and an accelerated titration schedule was used until standard 3 + 3 dose-escalation cohorts were implemented. Pharmacokinetics were evaluated on day −7 and day 22 of cycle 1.
Results: Ninety-four patients (32F, 62M; ages, 39–87) received doses ranging from 20 to 210 mg QD. Dose levels up to and including 160 mg administered QD were well tolerated. Toxicities consisted of reversible elevations in aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin, fatigue, nausea, alopecia, and muscle spasms. IPI-926 was not associated with hematologic toxicity. IPI-926 pharmacokinetics were characterized by a slow absorption (Tmax = 2–8 hours) and a terminal half-life (t1/2) between 20 and 40 hours, supporting QD dosing. Of those HhP inhibitor-naïve patients with basal cell carcinoma (BCC) who received more than one dose of IPI-926 and had a follow-up clinical or Response Evaluation Criteria in Solid Tumors (RECIST) assessment, nearly a third (8 of 28 patients) showed a response to IPI-926 at doses ≥130 mg.
Conclusions: IPI-926 was well tolerated up to 160 mg QD within 28-day cycles, which was established as the recommended phase II dose and schedule for this agent. Single-agent activity of IPI-926 was observed in HhP inhibitor–naïve patients with BCC. Clin Cancer Res; 19(10); 2766–74. ©2013 AACR.
SMARCB1/INI1 Genetic Inactivation Is Responsible for Tumorigenic Properties of Epithelioid Sarcoma Cell Line VAESBJ
Authors: Brenca Monica , Rossi Sabrina , Lorenzetto Erica , Piccinin Elena , Piccinin Sara , Rossi Francesca Maria , Giuliano Alberto , Dei Tos Angelo Paolo , Maestro Roberta , Modena Piergiorgio 
Published: April 2013

Abstract
Epithelioid sarcoma is a rare soft tissue neoplasm that usually arises in the distal extremities of young adults. Epithelioid sarcoma presents a high rate of recurrences and metastases and frequently poses diagnostic dilemmas. We previously reported loss of tumor suppressor SMARCB1 protein expression and SMARCB1 gene deletion in the majority of epithelioid sarcoma cases. Unfortunately, no appropriate preclinical models of such genetic alteration in epithelioid sarcoma are available. In the present report, we identified lack of SMARCB1 protein due to a homozygous deletion of exon 1 and upstream regulatory region in epithelioid sarcoma cell line VAESBJ. Restoration of SMARCB1 expression significantly affected VAESBJ cell proliferation, anchorage-independent growth, and cell migration properties, thus supporting the causative role of SMARCB1 loss in epithelioid sarcoma pathogenesis. We investigated the translational relevance of this genetic background in epithelioid sarcoma and showed that SMARCB1 ectopic expression significantly augmented VAESBJ sensitivity to gamma irradiation and acted synergistically with flavopiridol treatment. In VAESBJ, both activated ERBB1/EGFR and HGFR/MET impinged on AKT and ERK phosphorylation. We showed a synergistic effect of combined inhibition of these 2 receptor tyrosine kinases using selective small-molecule inhibitors on cell proliferation. These observations provide definitive support to the role of SMARCB1 inactivation in the pathogenesis of epithelioid sarcoma and disclose novel clues to therapeutic approaches tailored to SMARCB1-negative epithelioid sarcoma. Mol Cancer Ther; 12(6); 1060–72. ©2013 AACR.
BRCA1: A Missing Link in the Fanconi Anemia/BRCA Pathway
Authors: D'Andrea Alan D. 
Published: April 2013

Abstract
Summary: Domchek and colleagues provide a case report of a 28-year-old woman with congenital abnormalities, inherited ovarian cancer, and carboplatin hypersensitivity. Interestingly, the woman had validated germline mutations in both BRCA1 alleles. These findings further implicate BRCA1 in the Fanconi anemia/BRCA pathway and have important implications for BRCA1 genetic testing. Cancer Discov; 3(4); 376–8. ©2013 AACR.
See related article by Domchek et al., p. 399
Hit Parade for Adoptive Cell Transfer Therapy: The Best T Cells for Superior Clinical Responses
Authors: Speiser Daniel E. 
Published: April 2013

AbstractSummary: Adoptive cell transfer (ACT) of T cells has great clinical potential, but the numerous variables of this therapy make choices difficult. A new study takes advantage of a novel technology for characterizing the T-cell responses of patients. If applied systematically, this approach may identify biomedical correlates of protection, thereby supporting treatment optimization. Cancer Discov; 3(4); 379–81. ©2013 AACR.See related article by Ma et al., p. 418
The Invisible Hand Illusion: Multisensory Integration Leads to the Embodiment of a Discrete Volume of Empty Space
Authors: Guterstam Arvid , Gentile Giovanni , Ehrsson H. Henrik 
Published: April 2013

AbstractThe dynamic integration of signals from different sensory modalities plays a key role in bodily self-perception. When visual information is used in the multisensory process of localizing and identifying one's own limbs, the sight of a body part often plays a dominant role. For example, it has repeatedly been shown that a viewed object must resemble a humanoid body part to permit illusory self-attribution of that object. Here, we report a perceptual illusion that challenges these assumptions by demonstrating that healthy (nonamputated) individuals can refer somatic sensations to a discrete volume of empty space and experience having an invisible hand. In 10 behavioral and one fMRI experiment, we characterized the perceptual rules and multisensory brain mechanisms that produced this “invisible hand illusion.” Our behavioral results showed that the illusion depends on visuotactile-proprioceptive integration that obeys key spatial and temporal multisensory rules confined to near-personal space. The fMRI results associate the illusion experience with increased activity in regions related to the integration of multisensory body-related signals, most notably the bilateral ventral premotor, intraparietal, and cerebellar cortices. We further showed that a stronger feeling of having an invisible hand is associated with a higher degree of effective connectivity between the intraparietal and ventral premotor cortices. These findings demonstrate that the integration of temporally and spatially congruent multisensory signals in a premotor-intraparietal circuit is sufficient to redefine the spatial boundaries of the bodily self, even when visual information directly contradicts the presence of a physical limb at the location of the perceived illusory hand.
Hemispheric Differences in the Voluntary Control of Spatial Attention: Direct Evidence for a Right-Hemispheric Dominance within Frontal Cortex
Authors: Duecker Felix , Formisano Elia , Sack Alexander T. 
Published: April 2013

Abstract
Lesion studies in neglect patients have inspired two competing models of spatial attention control, namely, Heilman's “hemispatial” theory and Kinsbourne's “opponent processor” model. Both assume a functional asymmetry between the two hemispheres but propose very different mechanisms. Neuroimaging studies have identified a bilateral dorsal frontoparietal network underlying voluntary shifts of spatial attention. However, lateralization of attentional processes within this network has not been consistently reported. In the current study, we aimed to provide direct evidence concerning the functional asymmetry of the right and left FEF during voluntary shifts of spatial attention. To this end, we applied fMRI-guided neuronavigation to disrupt individual FEF activation foci with a longer-lasting inhibitory patterned TMS protocol followed by a spatial cueing task. Our results indicate that right FEF stimulation impaired the ability of shifting spatial attention toward both hemifields, whereas the effects of left FEF stimulation were limited to the contralateral hemifield. These results provide strong direct evidence for right-hemispheric dominance in spatial attention within frontal cortex supporting Heilman's “hemispatial” theory. This complements previous TMS studies that generally conform to Kinsbourne's “opponent processor” model after disruption of parietal cortex, and we therefore propose that both theories are not mutually exclusive.
The Fluidity between the Oppressed of Israel and Israel the Oppressed Some Additional Notes to B. Gregory’s Analysis of Ben Sira 35:14-26
Authors: Beentjes Pancratius C. 
Published: April 2013

Abstract
In his analysis of Sir 35:14-26, B.C. Gregory argues that this passage opens with a plight of the individual poor person, but rather soon turns into a prayer by the nation of Israel. This short note adduces further evidence to that view by drawing attention to a particular function the Book of Lamentations has for the Ben Sira passage under investigation.
An Akkadian Demon in the Talmud: Between Šulak and Bar-Širiqa
Authors: Bamberger Avigail Manekin 
Published: April 2013

Abstract
This article examines the resemblance between the Talmudic privy demon (“Shed Bet ha-Kise”) and Šulak, a well-known Akkadian demon. There are four considerations that point to identifying the privy demon of the Talmud with the Babylonian demon Šulak: (1) They both dwell in the privy; (2) they both are demons that cause epilepsy, strokes, or sudden falls; (3) they both seem to have the form of a lion; and (4) their names (“Šulak” and “Bar Širiqa”) are very similar. This suggestion is yet another example of the presence of beliefs and opinions from the Ancient Near East that found an echo in the Babylonian Talmud, one that may be added to a number of examples given by M. Geller.
A GENERAL THEORY FOR THE ORIGIN OF GROWTH STRESSES IN REACTION WOOD: HOW TREES STAY UPRIGHT
Authors: Bamber Richard Kenneth 
Published: April 2013

A general theory for the origin of growth stresses in the reaction wood of trees is presented. In both gymnosperms and arboreal dicotyledons, stress is considered to arise from the cellulosic component of the wood. It is suggested that in gymnosperms, cellulose microfibrils behave as helical springs. The helical springs are thought to be laid down in a compressed state and thus exert a compressive force which acts to right or stabilise the tree.
In arboreal dicotyledons the cellulose microfibrils are laid down as extended, longitudinally oriented springs and thus exert a tensile force tending to right or stabilise the tree.
Contrary to the prevailing view, lignin is not considered to be involved in the generation of growth stress in reaction wood. It is suggested that the sole function of lignin is to cement the cellulosic constituents into a whole, thus ensuring the transmission of stresses through the wood. The low values of lignin often reported from tension wood and especially from gelatinous fibres is seen as a mechanism to facilitate the contraction of microfibils thus maximising longitudinal tensile stress. The high values of lignin in of compression wood is seen as a mechanism to increase the compressive strength of compression wood.
SEM OBSERVATIONS ON 'TAWARA-SHIBO' (A SERIES OF SWELLINGS ALONG THE AXIS) STEMS OF CHAMAECYPARIS OBTUSA
Authors: Nakada Ryogo , Kawamura Kaichiro 
Published: April 2013

The anatomy of tawara-shibo stems of Chamaecyparis obtusa (Siebold & Zucc.) Endl. was observed using a scanning electron microscope (SEM) and a light microscope. Tawara-shibo is a strange stem form with a series of swellings that appear at regular intervals along the stem axis. Multiseriate rays, trabeculae and related structures, and modified tracheids were frequently observed at swollen portions. These features were less frequent at non-swollen portions.
We conclude that abnormal cambial activities, occurring at regular longitudinal intervals, cause the formation and development of these three anatomical features and higher growth rates at swollen portions. As a result of differences in growth rate between swollen and non-swollen portions, the stem form of tawara-shibo develops. It is suggested that formation of the characteristics observed in tawara-shibo stems is genetically controlled by hormonal secretion into or within the cambium.
ANATOMICAL CHARACTERISATION AND VARIABILITY OF THE THISTLE CYNARA CARDUNCULUS IN VIEW OF PULPING POTENTIAL
Authors: Quilhó Teresa , Gominho Jorge , Pereira Helena 
Published: April 2013

The thistle Cynara cardunculus L. is an herbaceous perennial with high productivity that is harvested annually and is a potential fibre crop for paper pulp production. The anatomical variation within stalks was studied (base, middle and top) and compared in C. cardunculus plants at different development phases. The stalk of C. cardunculus includes an epidermis, cortex and a central cylinder with fibro-vascular bundles with phloem, xylem and a fibrous sheath that is variable in arrangement and size within and between plants.
At harvest, the pith represents 37% of the stalk transectional area and 7% of the total weight. There was a slight variation in quantitative features of, respectively, the three development groups studied; mean fibre length was 1.04 mm, 0.95 mm and 1.05 mm; mean fibre width was 15 μm, 16 μm and 21 μm; mean fibre wall thickness was 3.2 μm, 3.4 μm and 4.9 μm. Fibre length and width decreased within the stem from base to top, while fibre wall thickness increased. Mean vessel diameter was 22 μm and mean vessel element length 220–483 μm. In mature plants, parenchyma represents 39% of the total transectional area and fibres 25%. The proportion of fibres increases during plant development and in mature plants is highest at the stalk base.
As regards anatomical features, Cynara stalks compare favourably to other annual plants and fibre biometry indicates good potential for paper sheet forming and strength properties.
Revisiting the treatment of conduct problems in children with callous-unemotional traits
Authors: Hawes David J , Dadds Mark R , Brennan John , Rhodes Tracy , Cauchi Avril 
Published: April 2013

Objective: This study examined whether the diminished treatment response previously reported for children with conduct problems and high levels of callous-unemotional (CU) traits is evident when these traits are indexed using multi-informant data collected from mothers, fathers, and teachers. It also tested whether treatment outcomes associated with CU traits are independent of overlap between CU traits and autism spectrum disorder (ASD) symptoms. Method: Diagnostic data on oppositional defiant disorder (ODD) severity were collected pre-treatment (time 1) and at 6-month follow-up (time 2) in a sample of children ( N = 95; 67 boys, 28 girls) aged 3–9 years with clinic-referred conduct problems and comorbid symptoms in a range of diagnostic domains. Time 1 measures of CU traits and ASD symptoms were tested as predictors of time 2 ODD severity using structural equation modeling, with multi-informant ratings of CU traits modeled as a single latent variable. Results: Compared to children with low levels of CU traits, those with high levels exhibited more severe ODD symptoms at follow-up ( β = 0.33, SE = 0.08, p < 0.05), after controlling for pre-treatment severity, socio-economic status, other demographics (age, gender), and parameters of treatment (number of treatment sessions, medication status). Although CU traits and ASD symptoms were positively correlated, ASD symptoms showed no association with change in ODD severity from pre-treatment to follow-up. Likewise, the association between CU traits and ODD outcomes held when controlling for covariation between CU traits and ASD symptoms. Conclusions: Our findings replicate previous evidence that CU traits are uniquely associated with poor clinical outcomes among children treated for conduct problems, and show for the first time that this association is not accounted for by symptoms of ASD.
Evaluation of contrast-enhanced MR angiography in the follow-up of visceral arterial aneurysms after coil embolization
Authors: Iryo Yasuhiko , Ikushima Ichiro , Hirai Toshinori , Yonenaga Kazuchika , Yamashita Yasuyuki 
Published: April 2013

Background The placement of detachable coil has become the alternative method of treating visceral arterial aneurysms (VAAs). Imaging follow-up is necessary after coil embolization because of frequent incomplete occlusion. Purpose To compare contrast-enhanced magnetic resonance angiography (CE-MRA) at 3T with a reference standard of digital subtraction angiography (DSA) for the evaluation of VAAs after coil embolization. Material and Methods We treated 15 patients with VAA with coil embolization; eight had splenic artery aneurysms and seven had renal artery aneurysms. We packed the aneurysmal sac preserving native arterial circulation. For follow-up, all patients underwent CE-MRA at 3T and DSA. The results were classified according to coil occlusion: Class 1, complete occlusion; Class 2, residual neck; Class 3, aneurysmal filling. Results CE-MRA revealed 11 complete occlusions and four residual necks. DSA follow-up showed 12 complete occlusions and three residual necks. No aneurysmal filling occurred after treatment. Comparison of CE-MRA and DSA findings showed 93% agreement (14/15). CE-MRA allowed the detection of a residual neck in one misclassified case in which DSA showed occlusion. Coil-related artifacts were minimal and did not interfere with evaluation of the occlusion status of the VAAs. Conclusion CE-MRA at 3T provides high-quality images equivalent to DSA for the evaluation of VAAs after coil embolization. We suggest that CE-MRA at 3T might be used as the primary method for follow-up of VAAs after coil embolization.