bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal Association Between Atrial Fibrillation Burden in Cardiac Implantable Electronic Devices and the Risk of Heart Failure Hospitalization
Authors: Ahluwalia Nikhil , Koehler Jodi , Sarkar Shantanu , Vasudevan Neethu , Majumder Shubha , Landman Sean R. , Schilling Richard J. 
Published: June 2024

BACKGROUND:
Atrial fibrillation (AF) events in cardiac implantable electronic devices (CIEDs) are temporally associated with stroke risk. This study explores temporal differences in AF burden associated with HF hospitalization risk in patients with CIEDs.

METHODS:
Patients with HF events from the Optum de-identified Electronic Health Records from 2007 to 2021 and 120 days of preceding CIED-derived rhythm data from a linked manufacturer’s data warehouse were included. AF burden ≥5.5 h/d was defined as an AF event. The AF event burden in the case period (days 1–30 immediately before the HF event) was considered temporally associated with the HF event and compared with the AF event burden in a temporally dissociated control period (days 91–120 before the HF event). The odds ratio for temporally associated HF events and the odds ratio associated with poorly rate-controlled AF (>110 bpm) were calculated.

RESULTS:
In total, 7257 HF events with prerequisite CIED data were included; 957 (13.2%) patients had AF events recorded only in either their case (763 [10.5%]) or control (194 [2.7%]) periods, but not both. The odds ratio for a temporally associated HF event was 3.93 (95% CI, 3.36–4.60). This was greater for an HF event with a longer stay of >3 days (odds ratio, 4.51 [95% CI, 3.57–5.68]). In patients with AF during both the control and case periods, poor AF rate control during the case period also increased HF event risk (1.78 [95% CI, 1.22–2.61]). In all, 222 of 4759 (5%) patients without AF events before their HF event had an AF event in the 10 days following.

CONCLUSIONS:
In a large real-world population of patients with CIED devices, AF burden was associated with HF hospitalization risk in the subsequent 30 days. The risk is increased with AF and an uncontrolled ventricular rate. Our findings support AF monitoring in CIED algorithms to prevent HF admissions.
Waitlist Outcomes for Pediatric Heart Transplantation in the Current Era: An Analysis of the Pediatric Heart Transplant Society Database
Authors: Butts Ryan J. , Toombs Leah , Kirklin James K. , Schumacher Kurt R. , Conway Jennifer , West Shawn C. , Auerbach Scott , Bansal Neha , Zhao Hong , Cantor Ryan S. , Nandi Deipanjan , Peng David M. 
Published: June 2024

BACKGROUND:
Waitlist mortality (WM) remains elevated in pediatric heart transplantation. Allocation policy is a potential tool to help improve WM. This study aims to identify patients at highest risk for WM to potentially inform future allocation policy changes.

METHODS:

The Pediatric Heart Transplant Society database was queried for patients <18 years of age indicated for heart transplantation between January 1, 2010 to December 31, 2021.
Waitlist mortality
was defined as death while awaiting transplant or removal from the waitlist due to clinical deterioration. Because WM is low after the first year, analysis was limited to the first 12 months on the heart transplant list. Kaplan–Meier analysis and log-rank testing was conducted to compare unadjusted survival between groups. Cox proportional hazard models were created to determine risk factors for WM. Subgroup analysis was performed for status 1A patients based on body surface area (BSA) at time of listing, cardiac diagnosis, and presence of mechanical circulatory support.

RESULTS:

In total 5974 children met study criteria of which 3928 were status 1A, 1012 were status 1B, 963 were listed status 2, and 65 were listed status 7. Because of the significant burden of WM experienced by 1A patients, further analysis was performed in only patients indicated as 1A. Within that group of patients, those with smaller size and lower eGFR had higher WM, whereas those patients without congenital heart disease or support from a ventricular assist device (VAD) at time of listing had decreased WM. In the smallest size cohort, cardiac diagnoses other than dilated cardiomyopathy were risk factors for WM. Previous cardiac surgery was a risk factor in the 0.3 to 0.7 m
2
and >0.7 m
2
BSA groups. VAD support was associated with lower WM other than in the single ventricle cohort, where VAD was associated with higher WM. Extracorporeal membrane oxygenation and mechanical ventilation were associated with increased risk of WM in all cohorts.

CONCLUSIONS:
There is significant variability in WM among status-1A patients. Potential refinements to current allocation system should factor in the increased WM risk we identified in patients supported by extracorporeal membrane oxygenation or mechanical ventilation, single ventricle congenital heart disease on VAD support and small children with congenital heart disease, restrictive cardiomyopathy, or hypertrophic cardiomyopathy.
Empire and the Fashioning of Whiteness: Im/Material Culture in the British Atlantic World, c. 1660–1820
Authors: Lemire Beverly 
Published: June 2024

Abstract
Textiles played a crucial role in defining gender, rank, and race in British imperial expansion during the long eighteenth century. This period saw an emphasis on whiteness in skin and cloth, symbolizing social status and racial hierarchy, with laundering, largely performed by low-ranked and racialized women, maintaining pristine garments representing social “whiteness.” Everyday clothing, its care, and the opulent societal lifestyle of the elite, characterized by events such as masquerade balls, upheld the imperial ethos of race and reinforced social hierarchies. A critical history of empire must examine fabrics and their use, as well as the motivations behind material whiteness.
10. The Concept of ‘Atmosphere’ as a Bridge between Music and Spirituality
Authors: Sawicki Bernard Łukasz 
Published: June 2024

The notion of atmosphere adds a new dimension to metaphors and symbols attempting to describe both musical and spiritual experience. Speaking of atmosphere, the discourse on music or spirituality itself moves from the purely descriptive sphere into the realm of experience, shedding new light on its specificity and effects. Consequently, one can speak of a reinterpretation of such key concepts for spirituality and theology as the body, incarnation, transformation (conversion). Music can help to understand and express them better.
In this chapter, the above theses will be presented according to the following scheme: 1) A general outline of the philosophical and aesthetic significance of the concept of 'atmosphere'; 2) A presentation of the potential 'dimensions of atmosphere' in music (tonality, the event of performance, the context of listening to the music, the role of the title and the biography of the composer or performer); 3) A presentation of the potential 'dimensions' of spirituality (prayer and its context, celebration, the eloquence and expression of texts, encounter); 4) A demonstration of the common 'atmospheric' elements of music and spirituality: the experience of perception, moving, touching, the presence of the Other, encounter. One cannot deny that the concept of atmosphere functions best in the spirituality of religions based on personal contact with God. If so, it is not merely descriptive but can have a practical dimension, stimulating both the musical or spiritual experience as well as facilitating its interpretation by opening it up, through synesthesia, to the sensations and language of other arts.
Seasons, Shorelines, and Their Effects on the Tropical Circulation and Hydrological Cycle
Authors: McKinney Matthew , Mitchell Jonathan 
Published: June 2024

Abstract
This work is a direct continuation of McKinney et al., who attempted to create a planet with Earth-like temperatures and physical properties but with precipitation and circulation patterns that were Titan-like. McKinney et al. attempted to do so by changing only three basic planetary parameters: the ratio of dry land to ocean on the surface, the rotation period, and the volatility of the condensable. Each of these parameters is varied from an Earth-like value to a Titan-like one to analyze the climate transition between these two planetary archetypes. In this work, we expand on McKinney et al. by including a seasonal cycle and increasing the number of diagnostic criteria for determining Titan-like dynamics. The simulations use Earth-like obliquity and an Earth-like solar constant. We find that the presence of a dry land strip extending to at least 55°N/S is most effective at creating Titan-like climatic conditions on an otherwise Earth-like planet, such as high-latitude summer precipitation maxima and a low-humidity equator. In contrast, slow rotation and high atmospheric vapor abundance have minimal climatic impacts despite being characteristic features of Titan. Our experiments show that it is not difficult to produce distinctly Titan-like features in an Earth-like GCM with minimal changes to its fundamental parameters. This suggests that Earth-like planets could have a large range of global climate states throughout their history just through changes in topography. Similarly, Titan may have experienced more Earth-like climate states in periods where its tropics were wetter.
Weather System Contributions to High Streamflow in Halele‘a, Kaua‘i
Authors: Sears Mya J. , Nugent Alison D. , Tsang Yinphan 
Published: June 2024

Abstract
The northeasterly facing, windward side of the Island of Kaua‘i (part of the State of Hawai‘i, United States) is prone to heavy rainfall events due to its topographical features and geographical location. Persistent northeasterly trade winds, coupled with steep changes in elevation, create an ideal environment for orographic precipitation. In addition, due to Kaua‘i’s 22°N latitude, the island often experiences midlatitude weather features such as kona lows, upper-level lows, and cold fronts that frequently result in high rainfall and river discharge conditions. This work uses data from river gauges in Halele‘a to understand the seasonality and impacts of the main atmospheric disturbances on two rivers in the region. The seasonality study showed that the majority of extreme flooding events occurred during the cool season and were predominantly caused by cold fronts and upper-level troughs. The historical analysis used atmospheric disturbance cases to determine that kona lows were likely to cause high streamflow in both studied Halele‘a rivers, and upper-level lows had an approximately equal probability of causing high streamflow or not. The findings that come from this project can provide context to atmospheric disturbances in Halele‘a and help community members identify and anticipate the types of events that may contribute to flooding.

Significance Statement
The north shore of the Island of Kaua‘i is prone to extreme rainfall and flooding due to interactions between the typical wind patterns and the nearby mountain range. A majority of flooding events occur during the cool season (October–April) because most of the weather events that produce extreme rainfall occur during these months. Here, we examined the top 50 flooding events in two of Kaua‘i’s north shore rivers and found that cold fronts and upper-level low pressure systems are often responsible for flooding. Additionally, any kona low is likely to cause high streamflow. This study increases the understanding of flood causes and likelihood in northern Kaua‘i.
Headache prevalence and demographic associations in the Delhi and National Capital Region of India: estimates from a cross-sectional nationwide population-based study
Authors: Chowdhury Debashish , Krishnan Anand , Duggal Ashish , Amarchand Ritvik , Husøy Andreas , Steiner Timothy J. 
Published: June 2024

Abstract
Background
India is a large and populous country where reliable data on headache disorders are relatively scarce. This study in northern India (Delhi and National Capital Territory Region [NCR], including surrounding districts in the States of Haryana, Uttar Pradesh and Rajasthan) continues the series of population-based studies within the Global Campaign against Headache and follows an earlier study, using the same protocol and questionnaire, in the southern State of Karnataka.

Methods
This cross-sectional study used the Global Campaign’s established methodology. Biologically unrelated Indian nationals aged 18–65 years were included through multistage random sampling in both urban and rural areas of NCR. Interviews at unannounced household visits followed the structured Headache-Attributed Restriction, Disability, Social Handicap and Impaired Participation (HARDSHIP) questionnaire in its original English version or in the validated Hindi version. Demographic enquiry was followed by a neutral headache screening question and diagnostic questions based on the International Classification of Headache Disorders edition 3 (ICHD-3), which focused on each respondent’s most bothersome headache. Questions about headache yesterday (HY) enabled estimation of 1-day prevalence. A diagnostic algorithm first identified participants reporting headache on ≥ 15 days/month (H15+), diagnosing probable medication-overuse headache (pMOH) in those also reporting acute medication use on ≥ 15 days/month, and “other H15+” in those not. To all others, the algorithm applied ICHD-3 criteria in the order definite migraine, definite tension-type headache (TTH), probable migraine, probable TTH. Definite and probable diagnoses were combined.

Results
Adjusted for age, gender and habitation, 1-year prevalences were 26.3% for migraine, 34.1% for TTH, 3.0% for pMOH and 4.5% for other H15+. Female preponderance was seen in all headache types except TTH: migraine 35.7% vs. 15.1% (aOR = 3.3; p < 0.001); pMOH 4.3% vs. 0.7% (aOR = 5.1; p < 0.001); other H15 + 5.9% vs. 2.3% (aOR = 2.5; p = 0.08). One-day prevalence of (any) headache was 12.0%, based on reported HY. One-day prevalence predicted from 1-year prevalence and mean recalled headache frequency over 3 months was slightly lower (10.5%).

Conclusions
The prevalences of migraine and TTH in Delhi and NCR substantially exceed global means. They closely match those in the Karnataka study: migraine 25.2%, TTH 35.1%. We argue that these estimates can reasonably be extrapolated to all India.
A potentially lifesaving error: unintentional high-dose adrenaline administration in anaphylaxis-induced cardiac arrest; a case report
Authors: Hans Felix Patricius , Benning Leo , Pooth Jan-Steffen , Busch Hans-Jörg 
Published: June 2024

Abstract
Background
Cardiopulmonary resuscitation is a crucial skill for emergency medical services. As high-risk-low-frequency events pose an immense mental load to providers, concepts of crew resource management, non-technical skills and the science of human errors are intended to prepare healthcare providers for high-pressure situations. However, medical errors occur, and organizations and institutions face the challenge of providing a blame-free error culture to achieve continuous improvement by avoiding similar errors in the future. In this case, we report a critical medical error during an anaphylaxis-associated cardiac arrest, its handling and the unexpected yet favourable outcome for the patient.

Case presentation
During an out-of-hospital cardiac arrest due to chemotherapy-induced anaphylaxis, a patient received a 10-fold dose of epinephrine due to shortcomings in communication and standardization via a central venous port catheter. The patient converted from a non-shockable rhythm into a pulseless ventricular tachycardia and subsequently into ventricular fibrillation. The patient was cardioverted and defibrillated and had a return of spontaneous circulation with profound hypotension only 6 min after the administration of 10 mg epinephrine. The patient survived without any residues or neurological impairment.

Conclusions
This case demonstrates the potential deleterious effects of shortcomings in communication and deviation from standard protocols, especially in emergencies. Here, precise instructions, closed-loop communication and unambiguous labelling of syringes would probably have avoided the epinephrine overdose central to this case. Interestingly, this serious error may have saved the patient’s life, as it led to the development of a shockable rhythm. Furthermore, as the patient was still in profound hypotension after administering 10 mg of epinephrine, this high dose might have counteracted the severe vasoplegic state in anaphylaxis-associated cardiac arrest. Lastly, as the patient was receiving care for advanced malignancy, the likelihood of termination of resuscitation in the initial non-shockable cardiac arrest was significant and possibly averted by the medication error.
Molecular genetic diversity and linkage disequilibrium structure of the Egyptian faba bean using Single Primer Enrichment Technology (SPET)
Authors: Sallam Ahmed , Amro Ahmed , Mourad Amira M. I. , Rafeek Abdallah , Boerner Andreas , Eltaher Shamaseldeen 
Published: June 2024

AbstractFaba bean is an important legume crop. The genetic diversity among faba bean genotypes is very important for the genetic improvement of target traits. A set of 128 fab bean genotypes that are originally from Egypt were used in this study to investigate the genetic diversity and population structure. The 128 genotypes were genotyped using the Single Primer Enrichment Technology (SPET) by which a set of 6759 SNP markers were generated after filtration. The SNP markers were distributed on all chromosomes with a range extending from 822 (Chr. 6) to 1872 (Chr.1). The SNP markers had wide ranges of polymorphic information content (PIC), gene diversity (GD), and minor allele frequency. The analysis of population structure divided the Egyptian faba bean population into five subpopulations. Considerable genetic distance was found among all genotypes, ranging from 0.1 to 0.4. The highly divergent genotype was highlighted in this study and the genetic distance among genotypes ranged from 0.1 and 0.6. Moreover, the structure of linkage disequilibrium was studied, and the analysis revealed a low level of LD in the Egyptian faba bean population. A slow LD decay at the genomic and chromosomal levels was observed. Interestingly, the distribution of haplotype blocks was presented in each chromosome and the number of haplotype block ranged from 65 (Chr. 4) to 156 (Chr. 1). Migration and genetic drift are the main reasons for the low LD in the Egyptian faba bean population. The results of this study shed light on the possibility of the genetic improvement of faba bean crop in Egypt and conducting genetic association analyses to identify candidate genes associated with target traits (e.g. protein content, grain yield, etc.) in this panel.
UnCoVar: a reproducible and scalable workflow for transparent and robust virus variant calling and lineage assignment using SARS-CoV-2 as an example
Authors: Thomas Alexander , Battenfeld Thomas , Kraiselburd Ivana , Anastasiou Olympia , Dittmer Ulf , Dörr Ann-Kathrin , Dörr Adrian , Elsner Carina , Gosch Jule , Le-Trilling Vu Thuy Khanh , Magin Simon , Scholtysik René , Yilmaz Pelin , Trilling Mirko , Schöler Lara , Köster Johannes , Meyer Folker 
Published: June 2024

Abstract
Background
At a global scale, the SARS-CoV-2 virus did not remain in its initial genotype for a long period of time, with the first global reports of variants of concern (VOCs) in late 2020. Subsequently, genome sequencing has become an indispensable tool for characterizing the ongoing pandemic, particularly for typing SARS-CoV-2 samples obtained from patients or environmental surveillance. For such SARS-CoV-2 typing, various in vitro and in silico workflows exist, yet to date, no systematic cross-platform validation has been reported.

Results
In this work, we present the first comprehensive cross-platform evaluation and validation of in silico SARS-CoV-2 typing workflows. The evaluation relies on a dataset of 54 patient-derived samples sequenced with several different in vitro approaches on all relevant state-of-the-art sequencing platforms. Moreover, we present UnCoVar, a robust, production-grade reproducible SARS-CoV-2 typing workflow that outperforms all other tested approaches in terms of precision and recall.

Conclusions
In many ways, the SARS-CoV-2 pandemic has accelerated the development of techniques and analytical approaches. We believe that this can serve as a blueprint for dealing with future pandemics. Accordingly, UnCoVar is easily generalizable towards other viral pathogens and future pandemics. The fully automated workflow assembles virus genomes from patient samples, identifies existing lineages, and provides high-resolution insights into individual mutations. UnCoVar includes extensive quality control and automatically generates interactive visual reports. UnCoVar is implemented as a Snakemake workflow. The open-source code is available under a BSD 2-clause license at github.com/IKIM-Essen/uncovar.
The genomic landscape of Ménière's disease: a path to endolymphatic hydrops
Authors: Fisch Kathleen M. , Rosenthal Sara Brin , Mark Adam , Sasik Roman , Nasamran Chanond A. , Clifford Royce , Derebery M. Jennifer , Boussaty Ely , Jepsen Kristen , Harris Jeffrey , Friedman Rick A. 
Published: June 2024

Abstract
Background
Ménière's disease (MD) is a disorder of the inner ear that causes episodic bouts of severe dizziness, roaring tinnitus, and fluctuating hearing loss. To date, no targeted therapy exists. As such, we have undertaken a large whole genome sequencing study on carefully phenotyped unilateral MD patients with the goal of gene/pathway discovery and a move towards targeted intervention. This study was a retrospective review of patients with a history of Ménière's disease. Genomic DNA, acquired from saliva samples, was purified and subjected to whole genome sequencing.

Results
Stringent variant calling, performed on 511 samples passing quality checks, followed by gene-based filtering by recurrence and proximity in molecular interaction networks, led to 481 high priority MD genes. These high priority genes, including MPHOSPH8, MYO18A, TRIOBP, OTOGL, TNC, and MYO6, were previously implicated in hearing loss, balance, and cochlear function, and were significantly enriched in common variant studies of hearing loss. Validation in an independent MD cohort confirmed 82 recurrent genes. Pathway analysis pointed to cell–cell adhesion, extracellular matrix, and cellular energy maintenance as key mediators of MD. Furthermore, the MD-prioritized genes were highly expressed in human inner ear hair cells and dark/vestibular cells, and were differentially expressed in a mouse model of hearing loss.

Conclusion
By enabling the development of model systems that may lead to targeted therapies and MD screening panels, the genes and variants identified in this study will inform diagnosis and treatment of MD.