bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Solid State Synthesis, Characterization, Optical Properties and Cooperative Catalytic Performance of Bismuth Vanadate Nanocatalyst for Biginelli Reactions.
Authors: Khademinia Shahin , Behzad Mahdi , Jahromi Hamideh Samari 
Published: July 2015

AbstractThe new nanocatalyst shows excellent catalytic efficiency in the Biginelli reaction under solvent‐free conditions.
ChemInform Abstract: Synthesis and Biological Evaluation of Novel 1,2‐Naphthoquinones Possessing Tetrazolo[1,5‐a]pyrimidine Scaffolds as Potent Antitumor Agents.
Authors: Wu Liqiang 
Published: July 2015

AbstractThe solvent free one‐pot reaction of 2‐hydroxy‐1,4‐naphthoquinone (I), 5‐aminotetrazole (II), and various aldehydes (III) gives the title compounds.
ChemInform Abstract: Synthesis and Characterization on Novel Fluorescent Sensors for Pd2+/Pd0 with High Selectivity.
Authors: Zi You , Meng Hua , Chu Xue‐Qiang , Xu Xiao‐Ping , Ji Shun‐Jun 
Published: July 2015

Abstract3 Imidazopyrazines of type (III) are prepared.
ChemInform Abstract: Organocatalytic Diboration Involving “Reductive Addition” of a Boron—Boron σ‐Bond to 4,4′‐Bipyridine.
Authors: Ohmura Toshimichi , Morimasa Yohei , Suginome Michinori 
Published: July 2015

AbstractStarting from 4,4′‐bipyridines conditions for a scalable reductive two‐fold addition of bis(pinacolato)diboron are developed.
ChemInform Abstract: Highly Efficient Regioselective Hydrosilylation of Allenes Using a [(3IP)Pd(allyl)]OTf Catalyst; First Example of Allene Hydrosilylation with Phenyl‐ and Diphenylsilane.
Authors: Tafazolian Hosein , Schmidt Joseph A. R. 
Published: July 2015

AbstractIn every case only a single isomer is formed.
ChemInform Abstract: Pd‐Catalyzed Enantiodivergent and Regiospecific phospha‐Michael Addition of Diphenylphosphine to 4‐Oxo‐Enamides: Efficient Access to Chiral Phosphinocarboxamides and Their Analogues.
Authors: Chew Renta Jonathan , Li Xi‐Rui , Li Yongxin , Pullarkat Sumod A. , Leung Pak‐Hing 
Published: July 2015

AbstractThe first catalytic asymmetric phospha‐Michael addition of diphenylphosphine to 4‐oxo‐enamide using a palladacycle catalyst is developed.
ChemInform Abstract: Ruthenium‐Catalyzed Thioglycosylation: Synthesis of 2,3‐Unsaturated‐S‐glycosides.
Authors: Battina Suresh Kumar , Reddy Thurpu Raghavender , Radha Krishna Palakodety , Kashyap Sudhir 
Published: July 2015

AbstractVarious thiols react smoothly with glycals to give the corresponding S‐linked glycosides regio‐ and stereoselectively.
ChemInform Abstract: Asymmetric Total Synthesis of (+)‐Dragmacidin D Reveals Unexpected Stereocomplexity.
Authors: Zhang Fengying , Wang Bin , Prasad Pritesh , Capon Robert J. , Jia Yanxing 
Published: July 2015

AbstractThe first asymmetric total synthesis of (+)‐dragmacidin D (I) revises an earlier configurational assignment based on biosynthetic considerations and assigns an R‐configuration to (+)‐I.
ChemInform Abstract: Chojalactones A—C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium
Authors: Hoshino Shotaro , Wakimoto Toshiyuki , Onaka Hiroyasu , Abe Ikuro 
Published: July 2015

Abstractisolation, structure including absolute configuration and cytotoxicity of three new butanolide chojalactones A—C with unusual γ‐butyrolactone scaffolds
ChemInform Abstract: Novel Neurotrophic Phenylbutenoids from Indonesian Ginger Bangle, Zingiber purpureum.
Authors: Kubo Miwa , Gima Minori , Baba Kohei , Nakai Megumi , Harada Kenichi , Suenaga Midori , Matsunaga Yoichi , Kato Eishin , Hosoda Shinya , Fukuyama Yoshiyasu 
Published: July 2015

AbstractTwo new curcuminoids (I), and a new phenylbutenoid dimer (II) are isolated from Bangle (Zingiber purpureum).
ChemInform Abstract: Two‐Step Pressure‐Induced Superhydration in Small Pore Natrolite with Divalent Extra‐Framework Cations.
Authors: Seoung Donghoon , Lee Yongmoon , Kao Chi‐Chang , Vogt Thomas , Lee Yongjae 
Published: July 2015

AbstractK‐natrolite is prepared by combining a 4 M KNO3 solution with the natural mineral Na16Al16Si24O80 ·16H2O in a 100:1 weight ratio for 24 h.
ChemInform Abstract: Investigation of Structural and Electronic Properties of Epitaxial Graphene on 3C‐SiC(100)/Si(100) Substrates
Authors: Gogneau Noelle , Trabelsi Amira Ben Gouider , Silly Mathieu G. , Ridene Mohamed , Portail Marc , Michon Adrien , Oueslati Mehrezi , Belkhou Rachid , Sirotti Fausto , Ouerghi Abdelkarim 
Published: July 2015

AbstractReview: 81 refs.
ChemInform Abstract: Biologically Active Benzimidazole Derivatives
Authors: Arulmurugan Subramaniyan , Kavitha Helen P. , Sathishkumar Samiyappan , Arulmozhi Rajaram 
Published: July 2015

AbstractReview: literature data on the synthesis and biological activities of benzimidazoles dring the past few years 2000‐2013; 82 refs.
ChemInform Abstract: Synthesis and Antimalarial Activities of Chalcone Derivatives
Authors: Ugwu David I. , Ezema Benjamin E. , Eze Florence U. , Onoabedje Efeturi A. , Ezema Chidimma G. , Ekoh Ogechi C. , Ayogu Jude I. 
Published: July 2015

AbstractReview: 120 refs.
ChemInform Abstract: Biophysical, Biopharmaceutical and Toxicological Significance of Biomedical Nanoparticles
Authors: Aula Sangeetha , Lakkireddy Samyuktha , Jamil Kaiser , Kapley Atya , Swamy A. V. N. , Lakkireddy Harivardhan Reddy 
Published: July 2015

AbstractReview: 234 refs.
ChemInform Abstract: Preparation and Biodistribution of 1‐((2‐Methoxyphenyl) piperazine)ferrocenecarboxamide Labeled with Technetium‐99m as a Potential Brain Receptor Imaging Agent
Authors: Saied Nadia Malek , Mejri Najoua , El Aissi Radhia , Benoist Eric , Saidi Mouldi 
Published: July 2015

AbstractReview: 26 refs.
ChemInform Abstract: Applications of Supramolecular Capsules Derived from Resorcin[4]arenes, Calix[n]arenes and Metallo‐Ligands: From Biology to Catalysis
Authors: Gangemi Chiara M. A. , Pappalardo Andrea , Trusso Sfrazzetto Giuseppe 
Published: July 2015

AbstractReview: 159 refs.
ChemInform Abstract: Advances in Solid‐Catalytic and Non‐Catalytic Technologies for Biodiesel Production
Authors: Islam Aminul , Taufiq‐Yap Yun Hin , Chan Eng‐Seng , Moniruzzaman M. , Islam Saiful , Nabi Md. Nurun 
Published: July 2015

AbstractReview: 207 refs.
No‐Regret‐Lösungen – Modulare Produktionskonzepte für komplexe, unsichere Zeiten
Authors: Mothes Helmut 
Published: July 2015

AbstractZunehmender Wettbewerb, kürzere Produktzyklen, vielfältigere Produktpaletten und häufigere Technologieinnovationen machen Produktionssysteme immer komplexer und Prognosen zu Produktnachfrage, Rohstoffsituation und Technologieveränderungen während des Produktlebenszyklus zu einer Mission Impossible. Zukünftige Produktionssysteme müssen daher durch eine konsequente Modularisierungsstrategie als flexible No‐Regret‐Lösungen ausgelegt werden, die die Gewinnmaximierung durch eine Risikominimierung ergänzen. Additive Manufacturing und Industrie 4.0‐Konzepte werden die Wirtschaftlichkeit modularer Systeme in der chemisch‐pharmazeutischen Industrie deutlich verbessern.
Patient specific modeling of palpation‐based prostate cancer diagnosis: effects of pelvic cavity anatomy and intrabladder pressure
Authors: Palacio‐Torralba Javier , Jiménez Aguilar Elizabeth , Good Daniel W. , Hammer Steven , McNeill S. Alan , Stewart Grant D. , Reuben Robert L. , Chen Yuhang 
Published: July 2015

SummaryComputational modeling has become a successful tool for scientific advances including understanding the behavior of biological and biomedical systems as well as improving clinical practice. In most cases, only general models are used without taking into account patient‐specific features. However, patient specificity has proven to be crucial in guiding clinical practice because of disastrous consequences that can arise should the model be inaccurate. This paper proposes a framework for the computational modeling applied to the example of the male pelvic cavity for the purpose of prostate cancer diagnostics using palpation. The effects of patient specific structural features on palpation response are studied in three selected patients with very different pathophysiological conditions whose pelvic cavities are reconstructed from MRI scans. In particular, the role of intrabladder pressure in the outcome of digital rectal examination is investigated with the objective of providing guidelines to practitioners to enhance the effectiveness of diagnosis. Furthermore, the presence of the pelvic bone in the model is assessed to determine the pathophysiological conditions in which it has to be modeled. The conclusions and suggestions of this work have potential use not only in clinical practice and also for biomechanical modeling where structural patient‐specificity needs to be considered. © 2015 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.
Intercalation of Nickel(II) and Iron(II) Metallosupramolecular Polyelectrolytes in Montmorillonite: Nanocomposites and their Electrorheological Properties
Authors: Geist Matthias F. , Peyratout Claire S. , Kurth Dirk G. 
Published: July 2015

AbstractNanocomposites obtained from the montmorillonite clay (Na0.36(Al1.64Mg0.36)Si4O10(OH)2⋅n H2O) and metallosupramolecular polyelectrolytes (MEPE) with iron(II) and nickel(II) are prepared by an aqueous intercalation reaction. Intercalation of MEPE in the interlayer structure of montmorillonite (MMT) is confirmed by different analytical techniques including powder X‐ray diffraction, FTIR spectroscopy, and thermal analysis. We note a difference in the intercalation behavior between NiII and FeII. The intercalation of Fe‐MEPE is hindered by traces of Fe2O3 in MMT. Removal of the impurities with sodium dithionite and citrate buffer makes Fe‐MEPE‐MMT available. Electrorheological measurements reveal for both nanocomposites a distinctive ER effect. The effect depends on the intercalated coordination polymer. Dielectric spectroscopy shows a different polarization for Fe‐MEPE‐MMT and Ni‐MEPE‐MMT.
Reduction of Charge and Discharge Polarization by Cobalt Nanoparticles‐Embedded Carbon Nanofibers for Li–O2 Batteries
Authors: Kim Yun‐Jung , Lee Hongkyung , Lee Dong Jin , Park Jung‐Ki , Kim Hee‐Tak 
Published: July 2015

AbstractThe problem of high charge polarization is one of the most significant challenges in current nonaqueous Li–O2 batteries. The development of an electrode for the oxygen evolution reaction (OER) at reduced overpotential is thus essential. Here, we suggest a binder‐free electrode based on Co nanoparticles embedded in carbon nanofibers (Co–CNFs), which simultaneously reduces the charge and discharge polarization and extends cycling stability. Co–CNF gives rise to a lower discharge polarization because of an enhanced oxygen reduction reaction activity compared to Co‐free CNF. Although the embedment of Co does not enhance the OER activity, it significantly reduces charge overvoltage by forming easily decomposable amorphous Li2O2. A mechanism for the formation of amorphous Li2O2 is suggested in terms of charge localization induced by the Co NPs. The findings suggest a new electrode design strategy of combining inexpensive metals and carbon materials for modulating the phase of the discharge product.
EphA7 regulates spiral ganglion innervation of cochlear hair cells
Authors: Kim Young J. , Ibrahim Leena A. , Wang Sheng‐Zhi , Yuan Wei , Evgrafov Oleg V. , Knowles James A. , Wang Kai , Tao Huizhong W. , Zhang Li I. 
Published: July 2015

ABSTRACTDuring the development of periphery auditory circuitry, spiral ganglion neurons (SGNs) form a spatially precise pattern of innervation of cochlear hair cells (HCs), which is an essential structural foundation for central auditory processing. However, molecular mechanisms underlying the developmental formation of this precise innervation pattern remain not well understood. Here, we specifically examined the involvement of Eph family members in cochlear development. By performing RNA‐sequencing for different types of cochlear cell, in situ hybridization, and immunohistochemistry, we found that EphA7 was strongly expressed in a large subset of SGNs. In EphA7 deletion mice, there was a reduction in the number of inner radial bundles originating from SGNs and projecting to HCs as well as in the number of ribbon synapses on inner hair cells (IHCs), as compared with wild‐type or heterozygous mutant mice, attributable to fewer type I afferent fibers. The overall activity of the auditory nerve in EphA7 deletion mice was also reduced, although there was no significant change in the hearing intensity threshold. In vitro analysis further suggested that the reduced innervation of HCs by SGNs could be attributed to a role of EphA7 in regulating outgrowth of SGN neurites as knocking down EphA7 in SGNs resulted in diminished SGN fibers. In addition, suppressing the activity of ERK1/2, a potential downstream target of EphA7 signaling, either with specific inhibitors in cultured explants or by knocking out Prkg1, also resulted in reduced SGN fibers. Together, our results suggest that EphA7 plays an important role in the developmental formation of cochlear innervation pattern through controlling SGN fiber ontogeny. Such regulation may contribute to the salience level of auditory signals presented to the central auditory system. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 452–469, 2016
Zebrafish TARP Cacng2 is required for the expression and normal development of AMPA receptors at excitatory synapses
Authors: Roy Birbickram , Ahmed Kazi T. , Cunningham Marcus E. , Ferdous Jannatul , Mukherjee Rajarshi , Zheng Wang , Chen Xing‐Zhen , Ali Declan W. 
Published: July 2015

ABSTRACTFast excitatory synaptic transmission in the CNS is mediated by the neurotransmitter glutamate, binding to and activating AMPA receptors (AMPARs). AMPARs are known to interact with auxiliary proteins that modulate their behavior. One such family of proteins is the transmembrane AMPA receptor‐related proteins, known as TARPs. Little is known about the role of TARPs during development, or about their function in non‐mammalian organisms. Here we report the presence of TARPs, specifically the prototypical TARP, stargazin, in developing zebrafish. We find that zebrafish express two forms of stargazin, Cacng2a and Cacng2b from as early as 12‐h post fertilization (hpf). Knockdown of Cacng2a and Cacng2b via splice‐blocking morpholinos resulted in embryos that exhibited deficits in C‐start escape responses, showing reduced C‐bend angles, smaller tail velocities and aberrant C‐bend turning directions. Injection of the morphants with Cacng2a or 2b mRNA rescued the morphological phenotype and the synaptic deficits. To investigate the effect of reduced Cacng2a and 2b levels on synaptic physiology, we performed whole cell patch clamp recordings of AMPA mEPSCs from zebrafish Mauthner cells. Knockdown of Cacng2a results in reduced AMPA currents and lower mEPSC frequencies, whereas knockdown of Cacng2b displayed no significant change in mEPSC amplitude or frequency. Non‐stationary fluctuation analysis confirmed a reduction in the number of active synaptic receptors in the Cacng2a but not in the Cacng2b morphants. Together, these results suggest that Cacng2a is required for normal trafficking and function of synaptic AMPARs, while Cacng2b is largely non‐functional with respect to the development of AMPA synaptic transmission. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 487–506, 2016
Linking stream ecology with morphological variability in a native freshwater fish from semi‐arid Australia
Authors: Lostrom Samantha , Evans Jonathan P. , Grierson Pauline F. , Collin Shaun P. , Davies Peter M. , Kelley Jennifer L. 
Published: July 2015

AbstractEnvironmental variation is a potent force affecting phenotypic expression. While freshwater fishes have provided a compelling example of the link between the environment and phenotypic diversity, few studies have been conducted with arid‐zone fishes, particularly those that occur in geographically isolated regions where species typically inhabit intermittent and ephemeral creeks. We investigated morphological variation of a freshwater fish (the western rainbowfish,Melanotaenia australis) inhabiting creeks in the Pilbara region of northwest Australia to determine whether body shape variation correlated with local environmental characteristics, including water velocity, habitat complexity, predator presence, and food availability. We expected that the geographic isolation of creeks within this arid region would result in habitat‐specific morphological specializations. We used landmark‐based geometric morphometrics to quantify the level of morphological variability in fish captured from 14 locations within three distinct subcatchments of a major river system. Western rainbowfish exhibited a range of morphologies, with variation in body depth accounting for a significant proportion (>42%) of the total variance in shape. Sexual dimorphism was also apparent, with males displaying deeper bodies than females. While the measured local habitat characteristics explained little of the observed morphological variation, fish displayed significant morphological differentiation at the level of the subcatchment. Local adaptation may partly explain the geographic patterns of body shape variation, but fine‐scale genetic studies are required to disentangle the effects of genetic differentiation from environmentally determined phenotypic plasticity in body shape. Developing a better understanding of environment–phenotype relationships in species from arid regions will provide important insights into ecological and evolutionary processes in these unique and understudied habitats.
High Sensitivity InAs DQW Linear Hybrid Hall ICs with InAs Deep Quantum Well Hall Elements
Authors: SHIBASAKI ICHIRO , KURIYAMA KENJI , MAKINO TAKASHI , HUKASAWA NAOYA , SUZUKI KENJI 
Published: July 2015

SUMMARYBy electrically connecting and placing an InAs deep quantum well (DQW) Hall element as a magnetic sensor chip and an Si IC linear amplifier in a small plastic package, a very small InAs DQW linear hybrid Hall IC (InAs DQW LHHIC) with a high magnetic field sensitivity has been developed. The output voltage of the hybrid Hall IC showed a very small temperature coefficient of 0.02%/°C and the response time was very low, less than 3 μs. By using this InAs DQW LHHIC, practical current sensors with high sensitivity, high accuracy, and temperature stability have been developed.
A Noise‐Free Adaptive Transversal Notch Filter Using the SSCF Algorithm with Decorrelation Parameter
Authors: KOBAYASHI MASAKI , NAGASAKA YASUNORI , ITOH YOSHIO 
Published: July 2015

SUMMARYAdaptive notch filters composed of an adaptive transversal filter have the limitation of bias error resulting from the broadband signal included in the input signal. In this paper, we propose an adaptive notch filter with a smaller bias error using a new adaptive algorithm based on the square sum of the correlation function with decorrelation parameter (SSCF‐DP). The cost function of the SSCF‐DP algorithm is the square sum of the cross‐correlation coefficient of the input and output error signal with the decorrelation parameter. The analytical results and the features described above are verified by computer simulation.
Construction and Evaluation of Digital Material Distribution Systems in Foreign Language Teaching
Authors: ONO YUICHI , ISHIHARA MANABU , YAMASHIRO MITSUO 
Published: July 2015

SUMMARYThis paper is concerned with an evaluation of participants' use of two multimedia distribution systems: PC‐based podcasting and mobile‐based distribution. We carried out two experiments: (i) evaluation of user's impressions when using these distribution systems and (ii) the relationship between download time and resulting frustration felt by users. The results of student questionnaires revealed that there is a statistical significance between these two systems and that mobile‐based podcasting was observed to have more salient factors concerning operability, such as “easy to operate” and “friendliness,” regardless of the difficulty of the content. Moreover, comparative study of the download time between the two systems showed that users did not feel less comfortable when downloading materials to mobile devices, even though mobiles took longer times to download materials than did a PC. These results lead us to the interesting idea that mobile devices have great potential to change the learning environment because they will play an important role in the so‐called “blended instruction” classroom environment when used in a traditional classroom setting in the near future.
Study of Prefrontal Blood Flow in Dementia Patients Using Near‐Infrared
Authors: TAKAHASHI SHINGO , KODAMA NAOKI , KOSUGI NAOKO , TAKEUCHI HIROSHI 
Published: July 2015

SUMMARYThe category frequency task has become one of the most important tools for measuring brain function. In this investigation, we used near‐infrared spectroscopy to examine the prefrontal blood flow in the brain, using a category fluency task function test to determine if this method can be used to diagnose dementia in the early stages. We examined 21 healthy volunteer students (age 21.0±1.4; 11 males and 10 females) and 50 patients with dementia (age 83.3±6.7; 12 males and 38 females; mini mental status: 0–22). The category fluency task required the subjects to produce nouns belonging to the category of vegetables. Our results showed that the healthy volunteer students had an increase in the blood flow while performing this task. On the other hand, the dementia patients did not show any relevant increase in blood flow while performing this task. The results suggest that the combination of the category fluency task and near‐infrared spectroscopy could be used as one more tool for the diagnosis of dementia.
Up‐regulation of micro‐RNA765 in human failing hearts is associated with post‐transcriptional regulation of protein phosphatase inhibitor‐1 and depressed contractility
Authors: Cai Wen‐Feng , Liu Guan‐Sheng , Lam Chi Keung , Florea Stela , Qian Jiang , Zhao Wen , Pritchard Tracy , Haghighi Kobra , Lebeche Djamel , Lu Long Jason , Deng Jingyuan , Fan Guo‐Chang , Hajjar Roger J. , Kranias Evangelia G. 
Published: July 2015

AimsImpaired sarcoplasmic reticulum (SR) Ca2+ cycling and depressed contractility, a hallmark of human and experimental heart failure, has been partially attributed to increased protein phosphatase 1 (PP‐1) activity, associated with down‐regulation of its endogenous inhibitor‐1. The levels and activity of inhibitor‐1 are reduced in failing hearts, contributing to dephosphorylation and inactivation of key calcium cycling proteins. Therefore, we investigated the mechanisms that mediate decreases in inhibitor‐1 by post‐transcriptional modification.Methods and ResultsBioinformatics revealed that 17 human microRNAs may serve as modulators of inhibitor‐1. However, real‐time PCR analysis identified only one of these microRNAs, miR‐765, as being increased in human failing hearts concomitant with decreased inhibitor‐1 levels. Expression of miR‐765 in HEK293 cells or mouse ventricular myocytes confirmed suppression of inhibitor‐1 levels through binding of this miR‐765 to the 3'‐untranslated region of inhibitor‐1 mRNA. To determine the functional significance of miR‐765 in Ca2+ cycling, pri‐miR‐765 as well as a non‐translated nucleotide sequence (miR‐Ctrl) were expressed in adult mouse ventricular myocytes. The inhibitor‐1 expression levels were decreased, accompanied by enhanced PP‐1 activity in the miR‐765 cardiomyocytes, and these reflected depressed contractile mechanics and Ca2+ transients, compared with the miR‐Ctrl group. The depressive effects were associated with decreases in the phosphorylation of phospholamban and SR Ca2+ load. These miR‐765 negative inotropic effects were abrogated in inhibitor‐1‐deficient cardiomyocytes, suggesting its apparent specificity for inhibitor‐1.ConclusionsmiR‐765 levels are increased in human failing hearts. Such increases may contribute to depressed cardiac function through reduced inhibitor‐1 expression and enhanced PP‐1 activity, associated with reduced SR Ca2+ load.