bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absolute Configurations of Four Resorcylic Acid Lactones, Paecilomycins J − M, by CD/TDDFT Calculations
Authors: Xu Liang‐Xiong , Xue Jing‐Hua , Wu Ping , You Xiao‐Ying , Wei Xiao‐Yi 
Published: November 2013

ABSTRACTThe absolute configurations of four resorcylic acid lactones (RALs), paecilomycins J − M (1 − 3 and 5), were assigned by Time‐Dependent Density‐Functional Theory (TDDFT) calculations of their electronic circular dichroism (CD) spectra. The previously reported structure 4 for paecilomycin M was found to be incorrect and should be changed to structure 5. Analysis of structure‐spectrum relationship for this group of RALs suggested that V′‐shape conformations give type I CD spectra (two negative Cotton effects around 300 and 260 nm, a positive Cotton effect around 220 nm) while V‐shape conformations yield type II spectra (signs of three Cotton effects were opposite to those in type I). Chirality 26:44–50, 2013. © 2013 Wiley Periodicals, Inc.
Generation of Tetrahydro‐3H‐indeno[2,1‐d]pyrimidines by the Tandem Reaction of 2‐(2‐Alkynylphenyl)aziridines with 2‐Iso­cyanoacetates
Authors: Zheng Danqing , Wu Jie 
Published: November 2013

AbstractA base‐promoted tandem reaction of 2‐(2‐alkynylphenyl)aziridines with 2‐isocyanoacetates in the presence of copper(II) triflate gives tetrahydro‐3H‐indeno[2,1‐d]pyrimidines in good yields, with the formation of two new rings and three bonds.
The moderating role of attribute accessibility in conditioning multiple specific attributes
Authors: Förderer Sabine , Unkelbach Christian 
Published: November 2013

AbstractAttribute conditioning (AC) refers to people's changed assessment of stimuli's (conditioned stimuli, CSs) attributes due to pairings with stimuli possessing these attributes (unconditioned stimuli, USs). Up to now, research only showed conditioning of only one attribute within a conditioning session (e.g., athleticism) and measured assessment changes in only this single attribute. The current study shows attribute‐specific AC effects in multi‐attribute environments and shows that attribute accessibility determines which of a US's multiple attributes are conditioned. Experiment 1 shows AC effects for artificial logos with attributes varying across USs (e.g., athletic, intelligent, or funny). Experiment 2 shows that these AC effects persist over time. Experiment 3 directly manipulated accessibility for attributes varying between and within USs (e.g., a US being sexy and familial) with a priming procedure. Priming‐specific attributes prior to conditioning determined which attribute of a US was conditioned to paired CSs. We discuss theoretical implications for AC, as well as practical implications for brand image formation and advertising. Copyright © 2013 John Wiley & Sons, Ltd.
Adenosine Triphosphate Sensing by Electrocatalysis with DNAzyme
Authors: Wang Guangfeng , Chen Ling , Zhu Yanhong , Wang Lun , Zhang Xiaojun 
Published: November 2013

AbstractElectrocatalysis of redox enzymes shows wide application for biosensing. DNAzymes exhibiting specific catalytic activities have aroused great interest recently. However, there are few studies on the electrocatalysis between DNAzyme and electron mediator. In this paper, based on the electrocatalysis of methylene blue (MB) and horseradish peroxidase mimicking DNAzyme (HRP‐DNAzyme), an amplified electrochemical biosensor for the detection of adenosine triphosphate (ATP) was designed. In the present system, by means of the ATP‐aptamer interaction, two guanine‐rich DNA sequences, one of which was labeled with MB at the 5′ end, were assembled on the gold electrode. In the presence of K+ and hemin, the guanine‐rich DNA sequences transferred to HRP‐DNAzyme. The conformational change of the structure resulted in the approaching of MB and HRP‐DNAzyme which made the electrocatalytic process between MB and HRP‐DNAzyme possible. We used cyclic voltammetry and electrochemical impedance spectroscopy to study the electrocatalytic process. The system was therefore utilized for amplified detection of ATP without imposing any new constraints to the platform which showed satisfactory result.
A High Performance Electrochemical Biosensing Platform for Glucose Detection and IgE Aptasensing Based on Fe3O4/Reduced Graphene Oxide Nanocomposite
Authors: Teymourian Hazhir , Salimi Abdollah , Firoozi Somayeh 
Published: November 2013

AbstractA Fe3O4 magnetic nanoparticles/reduced graphene oxide nanocomposite modified glassy carbon electrode (Fe3O4/r‐GO/GCE) was further expanded into the design of a high performance electrochemical biosensing platform. First, direct electrochemistry of glucose oxidase(GOx) immobilized onto Fe3O4/r‐GO/GCE and its biocatalytic activity toward glucose oxidation was investigated. Then, differential pulse voltammetry (DPV) was used to investigate the electrochemical oxidation behavior of four DNA free bases of guanine (G), adenine (A), thymine (T) and Cytosine (C) at Fe3O4/r‐GO/GCE. In addition, a label‐free electrochemical impedance spectroscopy (EIS) method of detection was developed for Immunoglobulin E (IgE) in which the binding of IgE‐specific aptamers immobilized on Fe3O4/r‐GO/GCE leads to impedance changes associated with IgE binding events.
The Clinical Implications of High Levels of Autism Spectrum Disorder Features in Anorexia Nervosa: A Pilot Study
Authors: Huke Vanessa , Turk Jeremy , Saeidi Saeideh , Kent Andrew , Morgan John. F. 
Published: November 2013

AbstractObjectiveThis study examined autism spectrum disorder (ASD) features in relation to treatment completion and eating disorder psychopathology in anorexia nervosa (AN).MethodThirty‐two adult women were recruited from specialist eating disorder services. Features of ASD and disordered eating were measured. Premature termination of treatment was recorded to explore whether ASD traits had impact on early discharge. A healthy control group was also recruited to investigate ASD traits between clinical and nonclinical samples.ResultsSignificant differences were found between the AN group and the healthy control group in obsessive‐compulsive disorder traits, depression and anxiety and ASD traits, with significant differences between groups in Social Skill and Attention Switching. The AN group reported no significant relationship between disordered eating severity and ASD traits. No significant effect was found between ASD features and treatment completion.DiscussionRaw data on premature termination of treatment, despite no statistic impact, showed that seven out of the eight participants with high features of ASD completed treatment as planned compared with 50% of those with low ASD traits. Unexpectedly, this suggests enhanced treatment adherence in ASD. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
A Versatile Omnibus Test for Detecting Mean and Variance Heterogeneity
Authors: Cao Ying , Wei Peng , Bailey Matthew , Kauwe John S. K. , Maxwell Taylor J. 
Published: November 2013

ABSTRACTRecent research has revealed loci that display variance heterogeneity through various means such as biological disruption, linkage disequilibrium (LD), gene‐by‐gene (G × G), or gene‐by‐environment interaction. We propose a versatile likelihood ratio test that allows joint testing for mean and variance heterogeneity (LRTMV) or either effect alone (LRTMorLRTV) in the presence of covariates. Using extensive simulations for our method and others, we found that all parametric tests were sensitive to nonnormality regardless of any trait transformations. Coupling our test with the parametric bootstrap solves this issue. Using simulations and empirical data from a known mean‐only functional variant, we demonstrate how LD can produce variance‐heterogeneity loci (vQTL) in a predictable fashion based on differential allele frequencies, high D′, and relatively lowr2values. We propose that a joint test for mean and variance heterogeneity is more powerful than a variance‐only test for detecting vQTL. This takes advantage of loci that also have mean effects without sacrificing much power to detect variance only effects. We discuss using vQTL as an approach to detect G × G interactions and also how vQTL are related to relationship loci, and how both can create prior hypothesis for each other and reveal the relationships between traits and possibly between components of a composite trait.
Beta‐type calcium phosphates with and without magnesium: From hydrolysis of brushite powder to robocasting of periodic scaffolds
Authors: Richard Raquel C. , Sader Márcia S. , Dai Jisen , Thiré Rossana M. S. M. , Soares Gloria D. A. 
Published: November 2013

AbstractSeveral approaches have attempted to replace extensive bone loss, but each of them has their limitation. Nowadays, additive manufacture techniques have shown great potential for bone engineering. The objective of this study was to synthesize beta tricalcium phosphate (β‐TCP), beta tricalcium phosphate substituted by magnesium (β‐TCMP), and biphasic calcium phosphate substituted by magnesium (BCMP) via hydrolysis and produce scaffolds for bone regeneration using robocasting technology. Calcium deficient apatites, with and without magnesium were obtained by hydrolysis, calcined and physico‐chemically characterized. Colorimetric cell viability assay, calcium nodule formation, and the expression of alkaline phosphatase, osteocalcin, transforming growth factor beta‐1 and collagen were assessed using a mouse osteoblastic cell line (MC3T3‐E1). Direct‐write assembly of cylindrical periodic scaffolds was done via robotic deposition using β‐TCP, β‐TCMP, and BCMP colloidal inks. The sintered scaffolds were characterized by X‐ray diffraction, Fourier‐transform infrared spectroscopy, scanning electron microscopy, Archimede's method, and uniaxial compression test. According to the cell viability assay, the powders induced cell proliferation. Calcium nodule formation and bone markers activity suggested that the materials present potential value in bone tissue engineering. The scaffolds built by robocasting presented interconnected porous and exhibited mean compressive strength between 7.63 and 18.67 MPa, compatible with trabecular bone. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3685–3692, 2014.
β‐Dicalcium silicate‐based cement: Synthesis, characterization and in vitro bioactivity and biocompatibility studies
Authors: Correa Daniel , Almirall Amisel , García‐Carrodeguas Raúl , Alberto dos Santos Luis , De Aza Antonio H. , Parra Juan , Ángel Delgado José 
Published: November 2013

Abstractβ‐dicalcium silicate (β‐Ca2SiO4, β‐C2S) is one of the main constituents in Portland cement clinker and many refractory materials, itself is a hydraulic cement that reacts with water or aqueous solution at room/body temperature to form a hydrated phase (C‐S‐H), which provides mechanical strength to the end product. In the present investigation, β‐C2S was synthesized by sol–gel process and it was used as powder to cement preparation, named CSiC. In vitro bioactivity and biocompatibility studies were assessed by soaking the cement samples in simulated body fluid solutions and human osteoblast cell cultures for various time periods, respectively. The results showed that the sol–gel process is an available synthesis method in order to obtain a pure powder of β‐C2S at relatively low temperatures without chemical stabilizers. A bone‐like apatite layer covered the material surface after soaking in SBF and its compressive strength (CSiC cement) was comparable with that of the human trabecular bone. The extracts of this cement were not cytotoxic and the cell growth and relative cell viability were comparable to negative control. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3693–3703, 2014.
A review of the preparation and application of flavour and essential oils microcapsules based on complex coacervation technology
Authors: Xiao Zuobing , Liu Wanlong , Zhu Guangyong , Zhou Rujun , Niu Yunwei 
Published: November 2013

AbstractThis paper briefly introduces the preparation and application of flavour and essential oils microcapsules based on complex coacervation technology. The conventional encapsulating agents of oppositely charged proteins and polysaccharides that are used for microencapsulation of flavours and essential oils are reviewed along with the recent advances in complex coacervation methods. Proteins extracted from animal‐derived products (gelatin, whey proteins, silk fibroin) and from vegetables (soy proteins, pea proteins), and polysaccharides such as gum Arabic, pectin, chitosan, agar, alginate, carrageenan and sodium carboxymethyl cellulose are described in depth. In recent decades, flavour and essential oils microcapsules have found numerous potential practical applications in food, textiles, agriculturals and pharmaceuticals. In this paper, the different coating materials and their application are discussed in detail. Consequently, the information obtained allows criteria to be established for selecting a method for the preparation of microcapsules according to their advantages, limitations and behaviours as carriers of flavours and essential oils. © 2013 Society of Chemical Industry
Multimodal treatment of locally advanced esophageal adenocarcinoma: Which regimen should we choose? Outcome analysis of perioperative chemotherapy versus neoadjuvant chemoradiation in 105 patients
Authors: Hoeppner Jens , Zirlik Katja , Brunner Thomas , Bronsert Peter , Kulemann Birte , Sick Olivia , Marjanovic Goran , Hopt Ulrich Theodor , Makowiec Frank 
Published: November 2013

AbstractBackgroundThe study was done to compare treatment and long‐term outcomes of neoadjuvant chemoradiation (neoCRT) and perioperative chemotherapy (periCTX) in patients with surgically treated esophageal adenocarcinoma.MethodsAn analysis of 105 patients with esophageal adenocarcinoma undergoing neoCRT (n = 58) or periCTX (n = 47) and esophagectomy between 2000 and 2012 was carried out.ResultsThe overall median survival was 5.97 years. Postoperative morbidity and in‐hospital mortality occurred in 74%/7% of the patients the neoCRT group and in 53%/0% of the patients in the periCTX group (P = 0.03/P = 0.08). Total or subtotal histological tumor response after neoadjuvant treatment and esophagectomy was found in 59% after neoCRT and 30% after periCTX (P < 0.01). Three‐ and five‐year survival rates were 52%/45% for neoCRT and 68%/63% for periCTX (P = 0.05). PeriCTX was identified as an independent predictor of survival (RR2.6; 95% CI 1.3–5.1; P < 0.01).ConclusionA higher rate of histologic response to neoCRT compared to histologic response following the preoperative cycles of periCTX does not translate to a benefit in overall survival. PeriCTX offers a decreased incidence of treatment‐related morbidity and mortality and at least equal results in terms of survival compared to neoCRT in patients with locally advanced esophageal adenocarcinoma. J. Surg. Oncol. 2014 109:287–293. © 2013 Wiley Periodicals, Inc.
Design of a multilayered six‐aperture directional coupler using substrate integrated waveguide
Authors: Mbaye Moustapha , Talbi Larbi , Hettak Khelifa 
Published: November 2013

ABSTRACTThe design of a six‐aperture, 10‐dB directional coupler using substrate integrated waveguide is presented. Size constraints precluded addition of holes in series, however, in parallel the addition enhanced performance without increasing size. Here, 10‐dB coupling with ±2‐dB coupling ripple and reflection coefficient exceeded that of 15 dB over 34% of bandwidth. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:23–27, 2014
Compact microstrip antennas using CSRR structure ground plane
Authors: Hu Jian‐Rong , Li Jiu‐Sheng 
Published: November 2013

ABSTRACTIn this article, a method for simultaneously enhancing the gain and reducing the size of microstrip antennas using a spiral complementary openings resonance ring (CSRR) structure ground plane has been presented. The proposed antenna is successfully designed and measured, which provides frequency band from 5.145∼5.387 GHz. By adjusting the size of the spiral CSRR on the ground plane, small size antenna of 25 × 25 × 0.8 mm3 and 5.8 dBi of relative high gain are achieved. Comparing the simulated and measured results confirm the suitability of the proposed antenna for wireless local area network application. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:117–120, 2014
Theoretical and experimental research on the effect of coupler splitting ratio for fiber loop ring‐down spectroscopy technology
Authors: Zhao Yong , Bai Lu , Wang Qi 
Published: November 2013

ABSTRACTThe Fiber Loop Ring‐down Spectroscopy (FLRDS) technique has become popular in recent years. However, as the ring‐down signal is a series of decaying pulses, very few pulses' peak intensities and their time delays could be found and fitted in an exponential equation. This paper analyzes the importance of splitting ratio of the couplers with respect to improving the accuracy of the fitted equation, makes mathematical models of the whole system, simulates the ring‐down signal under different splitting ratio of the couplers and establishes FLRDS experimental system. The experimental results are in good agreement with theory, which indicated that both of the two coupler splitting ratios of 10:90 are found to be the optimal solution with a ring‐down time of 24.5 µs in our system. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:99–103, 2014
Switchable and tunable microwave photonic filter based on reflective semiconductor optical amplifier
Authors: Xu Enming , Wang Fei , Li Peili 
Published: November 2013

ABSTRACTA microwave photonic filter, which can be switched between a high‐Q bandpass filter and a notch filter, is proposed and experimentally demonstrated. It is based on a recirculating delay line loop with a reflective semiconductor optical amplifier, and negative taps are generated employing wavelength conversion. The filter can be also tuned by adjusting an optical variable delay line. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:198–201, 2014
A mechanical tuning method for superconducting filter in both frequency domain and time domain
Authors: Song Xiaoke , Wei Bin , Cao Bisong , Guo Xubo , Zhang Xiaoping , Zheng Tianning , Wang Jingchen , Shang Zhaojiang 
Published: November 2013

ABSTRACTThis article presents a mechanical tuning method for high‐temperature superconducting (HTS) filter based on the frequency domain and the time domain using dielectric tuning rods and metallic tuning rods. The resonant frequency tuning effect with dielectric and metallic rods was analyzed using lumped‐element models. The simulation results showed that the resonant frequency of each resonator can be tuned separately. An eight‐pole HTS twin spiral filter was tuned with the proposed method in frequency domain and time domain simultaneously, as a demonstration. After tuning, the filter has a 16.82 dB return loss, a 0.26 dB insertion loss and a 0.14 dB in‐band ripple. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:217–223, 2014
Facets of the Tetsuo Nozoe Legacy Immortalized in an Enduring Series of International Symposia on Novel Aromatic Compounds (ISNA)
Authors: Scott Lawrence T. 
Published: November 2013

Note from the Editor:According to Robert K. Merton (1988), “Invisible college” is a term used “to designate the informal collectives of scientists interacting in their research on similar problems, these groups being generally limited to a size ‘that can be handled by interpersonal relationships.’ ” Invisible colleges can be highly competitive, even ugly in their priority races, or they can be congenial, even enthusiastically supportive to its members. In the community of organic chemists who studied novel aromatic chemistry in the 1950s–1990s, one man—Tetsuo Nozoe—is largely responsible for bringing together researchers from across the world and setting the tone of brotherhood. Larry Scott, today a senior scholar of that invisible college, warmly shares the spirit of Tetsuo Nozoe with each of us in the following essay. Jeffrey I. Seeman Guest Editor University of Richmond Richmond, Virginia 23173, USA E‐mail: jseeman@richmond.edu
Spatial‐temporal fusion for flotation froth image denoising based on BLS‐GSM method in curvelet domain
Authors: Liu Jinping , Gui Weihua , Tang Zhaohui , Chen Qing 
Published: November 2013

AbstractThe visual appearance of flotation froth surface involves a major cue about the flotation performance, which is significant for machine‐vision‐based flotation process monitoring and control. However, the froth image suffers from noise contamination inevitably, which incurs serious negative effects on the visual feature extraction of froth images. This paper presents a spatial‐temporal image denoising scheme based on statistical modeling of the froth image in the Curvelet domain and weighted processing of the relative patches of adjacent image sequences. First, the Gaussian scale‐mixture model of the image coefficients in the local spatial neighborhood is investigated according to their statistical distribution property to get the clean coefficients based on inner‐frame content by using Bayesian least‐squares estimation. Then, the temporal patches from adjacent image sequences are performed with weighted impact factors according to the similarities of the relative patches after motion compensation. Thus, clean image coefficients based on spatial‐temporal content are achieved. This method is validated by the simulated additive noise removal and the real industrial image processing. The results of simulation and real application of image noise elimination reveal the excellent performance of this method, which can effectively reconstruct the froth image while protecting more bubble details for the following froth description. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Increasing importance of truly informed consent: the role of written patient information
Authors: Kirby Roger , Challacombe Ben , Hughes Simon , Chowdhury Simon , Dasgupta Prokar 
Published: November 2013

AbstractComplaints to the General Medical Council (GMC) and litigation against doctors are currently rising at an alarming rate, with an increase of 23 per cent from 7153 in 2010 to 8781 in 2011.1 This equates to a 1:64 chance of the GMC investigating any individual doctor. Of all the causes of dissatisfaction among patients, one of the most common is the feeling that they ‘were not told’ that a particular outcome might result from a given treatment. Copyright © 2013 John Wiley & Sons