bluuebunny/crossref_metadata_2025_split huggingface dataset:
The doctrine of ancillary restrictions as a delimitation tool and an absorption principle: twin notions but not identical twins
Authors: Nagy Csongor István 
Published: August 2024

Abstract
Contrary to the general view, ‘ancillary restrictions’ designate two separate conceptions, which should be treated as separate doctrines. As a ‘delimitation tool’, ancillarity separates ‘naked’ and ‘ancillary’ restrictions based on ‘reasonable necessity’. As an ‘absorption principle’, ancillarity is a rule of thumb that screens out certain lawful agreements based on the idea that a lawful main transaction (or the legality of the main transaction) absorbs all objectively necessary (indispensable) restrictions.
Influence of autoencoder latent space on classifying IoT CoAP attacks
Authors: García-Ordás María Teresa , Aveleira-Mata Jose , García-Rodrígez Isaías , Luis Casteleiro-Roca José , Bayón-Gutiérrez Martín , Alaiz-Moretón Héctor 
Published: August 2024

Abstract
The Internet of Things (IoT) presents a unique cybersecurity challenge due to its vast network of interconnected, resource-constrained devices. These vulnerabilities not only threaten data integrity but also the overall functionality of IoT systems. This study addresses these challenges by exploring efficient data reduction techniques within a model-based intrusion detection system (IDS) for IoT environments. Specifically, the study explores the efficacy of an autoencoder’s latent space combined with three different classification techniques. Utilizing a validated IoT dataset, particularly focusing on the Constrained Application Protocol (CoAP), the study seeks to develop a robust model capable of identifying security breaches targeting this protocol. The research culminates in a comprehensive evaluation, presenting encouraging results that demonstrate the effectiveness of the proposed methodologies in strengthening IoT cybersecurity with more than a 99% of precision using only 2 learned features.
Refuge in the Levant and Eastern Mediterranean: Spaces of containment or places of choice?
Authors: Chatty Dawn 
Published: August 2024

Abstract
After the Anglo-American invasion of Iraq in 2003, the European Union became fixated on keeping refugees from the Middle East out of Europe. By 2015, with the mass influx of Syrians, Iraqis, and others, seeking safety across the Balkans, the European response was an extraordinary effort to push back and contain these displaced people within the Eastern Mediterranean region through physical barriers, bilateral agreements, and the establishment of refugee camps. This paper suggests that Europe’s efforts to keep displaced Syrians and Iraqis out of Europe were misguided. That is, contrary to what much of the European main media reported at the time, relatively few of those displaced Syrians and Iraqis had a strong desire to seek asylum in Europe. Rather, depending upon socio-economic and kinship networks, and historical ties developed over 500 years of Ottoman suzerainty, they preferred to remain in the region following long-established transnational socio-economic networks and kinship ties.
The propagation of inhomogeneous waves in an orthotropic viscoelastic medium
Authors: Tung Do Xuan 
Published: August 2024

Abstract
The present article deals with the propagation of inhomogeneous waves in an orthotropic viscoelastic medium. For chosen directions of propagation and a real finite inhomogeneity parameter, a complex slowness vector is specified to define the propagation of an inhomogeneous incident wave. Then, the reflection and transmission of plane waves at a plane interface between two orthotropic viscoelastic half-spaces are discussed. In this incidence, horizontal slowness determines the slowness vectors for all reflected and transmitted waves. For each reflected and transmitted wave, the corresponding slowness vector is resolved to define its phase direction, phase velocity and attenuation angle. Appropriate boundary conditions on this wave field determine the amplitude ratios for reflected and transmitted waves relative to the incident wave. The numerical examples are provided to show the effect of the inhomogeneity of the incident wave on the propagation characteristic as well as the reflection and transmission coefficients. The existence of homogeneous, inhomogeneous incident waves also is investigated.
Diagnostic challenges and burden of idiopathic hypersomnia: a systematic literature review
Authors: Boulanger Talia , Pigeon Pascale , Crawford Stephen 
Published: August 2024

Abstract
Idiopathic hypersomnia (IH) is a rare neurological sleep disorder, characterized by excessive daytime sleepiness despite normal sleep duration, that can significantly impact patient’s lives. The burden of IH goes beyond excessive daytime sleepiness, pervading all aspects of everyday life. Characteristic and burdensome symptoms of IH include sleep inertia/drunkenness, long sleep duration, and daytime cognitive dysfunction. This systematic review assessed current knowledge regarding IH diagnostic challenges and burden of illness. Literature searches for original epidemiological, clinical, humanistic, or economic research relevant to IH published between 2012 and 2022 in MEDLINE, Embase, Cochrane, gray literature (diagnostic criteria and treatment guidelines), conferences (2019–2022), and clinical trial databases yielded 97 articles. Findings indicate that IH remains a poorly defined diagnosis of exclusion that is difficult to distinguish from narcolepsy type 2 because of symptom overlap and inadequacies of objective testing. Consequently, individuals with IH endure diagnostic delays of up to 9 years. The economic burden of IH has not been characterized to any appreciable extent. Pharmacological treatment options can improve symptoms and functional status, but rarely restores normal levels of functioning. These findings highlight the need to reclassify central disorders of hypersomnolence. Further collaboration is now required between research groups to identify and validate objective markers to help redefine diagnostic criteria for IH. This would move IH into a position that could benefit from future targeted therapeutic interventions. The study was funded by Takeda Development Center Americas, Inc.
A Diazeniumdiolate Signal in Pseudomonas syringae Upregulates Virulence Factors and Promotes Survival in Plants
Authors: Guo Qiang , Vitro Caitlin N. , Crawford Drake M. , Li Bo 
Published: August 2024

Pseudomonas syringae infects a wide variety of crops. The mangotoxin-generating operon ( mgo) is conserved across many P. syringae strains and is responsible for producing an extracellular chemical signal, leudiazen. Disruption of the mgoA gene in P. syringae pv. syringae ( Pss) UMAF0158 alleviated tomato chlorosis caused by this bacterium. We showed that deletion of the entire mgo reduced Pss UMAF0158 population in tomato leaflets. Leudiazen restored the signaling activity of the deletion mutant at a concentration as low as 10 nM. Both the diazeniumdiolate and isobutyl groups of leudiazen are critical for this potent signaling activity. Transcriptional analysis showed that mgo and leudiazen induce the expression of mangotoxin biosynthetic operon as well as an uncharacterized gene cluster, RS17235–RS17245. We found that this cluster enhances the survival of Pss UMAF0158 in planta and is widely distributed in P. syringae strains. Our results demonstrate that mgo plays prominent roles in the virulence and growth of P. syringae. The mgo and mgo-like signaling systems in different bacteria likely regulate diverse microbe-host interactions. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
The Role of Oxalic Acid in Clarireedia jacksonii Virulence and Development on Creeping Bentgrass
Authors: Huo Daowen , Westrick Nathaniel M. , Nelson Ashley , Kabbage Mehdi , Koch Paul 
Published: August 2024

Dollar spot is a destructive foliar disease of amenity turfgrass caused by Clarireedia spp. fungi, mainly C. jacksonii, on the Northern United States region's cool-season grass. Oxalic acid (OA) is an important pathogenicity factor in related fungal plant pathogens such as Sclerotinia sclerotiorum; however, the role of OA in the pathogenic development of C. jacksonii remains unclear due to its recalcitrance to genetic manipulation. To overcome these challenges, a CRISPR/Cas9-mediated homologous recombination approach was developed. Using this novel approach, the oxaloacetate acetylhydrolase ( oah) gene that is required for the biosynthesis of OA was deleted from a C. jacksonii wild-type (WT) strain. Two independent knockout mutants, Δ Cjoah-1 and Δ Cjoah-2, were generated and inoculated on potted creeping bentgrass along with a WT isolate and a genome sequenced isolate LWC-10. After 12 days, bentgrass inoculated with the mutants Δ Cjoah-1 and Δ Cjoah-2 exhibited 59.41% lower dollar spot severity compared with the WT and LWC-10 isolates. OA production and environmental acidification were significantly reduced in both mutants when compared with the WT and LWC-10. Surprisingly, stromal formation was also severely undermined in the mutants in vitro, suggesting a critical developmental role of OA independent of plant infection. These results demonstrate that OA plays a significant role in C. jacksonii virulence and provide novel directions for future management of dollar spot. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Two years in a post-Dobbs world: clinical, social and professional consequences
Authors: Beshar Isabel , Corn Megan , Blumenthal Paul D. 
Published: August 2024

Purpose of review

Dobbs v Jackson Women's Health Organization revoked the decades-old precedent that pregnancy termination is a constitutional right. This review article explores the research landscape describing the consequences of overturning Roe v Wade for patients and providers.

Recent findings
To date, fourteen states have enforced total bans on abortion, with seven more restricting abortion access to levels not seen since before Roe. Dobbs has had immediate and swift consequences from clinical, social and professional perspectives, with increases in maternal mortality and demand for long-acting and permanent contraception, matched by declines in both access to methotrexate and applications to Obstetrics & Gynecology training programs.

Summary
Eighteen million patients now live in states where abortion access is highly if not completely inaccessible. Abortion restrictions have profound implications beyond those desiring pregnancy termination; future research should continue to explore the ways Dobbs has affected clinical care, public health and social practices.
Abortion in entertainment media, 2019–2024
Authors: Herold Stephanie 
Published: August 2024

Purpose of review
Entertainment media contribute to how people understand and make sense of health issues, especially stigmatized ones such as abortion. This paper reviews the peer-reviewed literature published between 2019 and 2024 on how abortion is depicted in scripted television and film available for viewing in the United States.

Recent findings
The majority of recent studies focus on qualitative content analysis of a composite of television shows, documenting the myriad ways that these programs reflect and are distinct from the reality of abortion access in the United States. The quantitative studies find small but significant increases in abortion knowledge related to exposure to television abortion plotlines, but no increases in support for abortion postexposure. No studies track the impact of exposure to multiple abortion plotlines at multiple points in time. Only one study included a sample of entertainment content creators to understand their motivations for creating abortion plotlines.

Summary
Media depictions of abortion are often rife with misinformation, and may influence the U.S. public's general knowledge and beliefs about abortion. More research is needed to understand possible relationships between television and film abortion content and its impact on viewers.
Adolescent reproductive health in a post-Dobbs landscape: a review
Authors: Doyle Alexis A. , Liu Serena M. , Tyson Nichole A. 
Published: August 2024

Purpose of review
To summarize notable recent research in adolescent reproductive health, particularly with respect to a rapidly changing legal landscape surrounding health services that significantly impact adolescent health.

Recent findings
Approval of the first over-the-counter contraceptive pill represented a major advance in adolescent reproductive health, which relied on research regarding its safety, efficacy, and potential to increase access for vulnerable groups. Despite this approval, disparities persist in equitable contraceptive access for adolescents of color and those from sexual and gender identity minorities. Legal changes in access to abortion care and parental involvement in reproductive health decision-making have presented significant challenges for young people across the U.S. Recent research points to the promise of telehealth abortion care and parental acceptance of confidentiality in adolescent reproductive healthcare. Misinformation remains a barrier to advancing adolescent reproductive health and points to continued opportunities for providers to create evidence-based online content.

Summary
In this review, we discuss recent research regarding adolescent reproductive health and laws impacting the reproductive health of adolescents. As the legal landscape evolves, further research surrounding the effect of policy changes that both expand and restrict access to adolescent reproductive health services will be critical to advancing adolescent health.
A Biologic With Otologic Consequences: Analysis of Hearing Loss and Teprotumumab Using the FDA Adverse Event Reporting System
Authors: Huynh Pauline P. , Saba Elias , Rivero Alexander , Peralta Robert , Liang Jonathan 
Published: August 2024

Objectives
To evaluate otologic adverse reactions (OARs), including hearing loss (OARs-HL) among patients taking teprotumumab, a new biologic approved for the treatment of active thyroid eye disease, using publicly available pharmacovigilance reporting data.

Study Design
Retrospective database review

Methods
The Food and Drug Administration Adverse Events Reporting System (FAERS) was queried for cases involving teprotumumab from 2020Q1 to 2023Q1. Patient demographics and adverse reactions (OAR and OAR-HL) were evaluated. Logistic regression was used to predict OAR and OAR-HL, and disproportionality analysis was performed using OpenVigil.

Results
A total of 2,109 teprotumumab-AR cases were reported, of which 296 (14.05%; mean age 55.46 yr) were OARs. Of these, 149 (7.06%) reported OAR-HL and 194 (9.20%) reported other OAR (e.g., tinnitus, ear discomfort, vertigo), with 47 (2.23%) reporting both. Disproportionality analysis showed a reported odds ratio (ROR) for OARs-HL of 44.33 (95% confidence interval [CI], 37.40–52.55; p < 0.001). Age was associated with RORs of 1.02 (95% CI, 1.01–1.04) and 1.04 (95% CI, 1.02–1.07) for developing OARs and specifically OARs-HL, respectively (p < 0.01). Age 50 and 65 years and older were associated with RORs of 2.54 (95% CI, 1.16–6.38) and 3.36 (95% CI, 1.75–6.53), respectively, for OARs-HL (p < 0.05).

Conclusion
This study using FAERS data suggests an increased risk of OARs, specifically hearing loss, associated with teprotumumab. Increasing age was a significant predictor of OARs. Audiometric counseling and evaluation should be considered with teprotumumab therapy in Graves' orbitopathy patients, especially in older patients.
Impact of Migraine on the Tinnitus-Specific Health-Related Quality of Life and Psychiatric Comorbidities in Patients with Tinnitus
Authors: Kabaya Kayoko , Takahashi Mariko , Esaki Shinichi , Minakata Toshiya , Iwasaki Shinichi 
Published: August 2024

Objective
To investigate the impact of migraine on the tinnitus-specific health-related quality of life (HRQOL) and psychiatric comorbidities in patients with tinnitus.

Methods
This cross-sectional study included 227 consecutive patients with tinnitus as their primary complaint. Patients who were diagnosed as having comorbid migraine were asked whether their tinnitus exacerbated during attacks of migraine. All the patients completed three questionnaires: the Tinnitus Handicap Inventory (THI), the Hearing Handicap Inventory for Adults (HHIA) or its counterpart for the Elderly (HHIE), and the Hospital Anxiety and Depression Scale (HADS).

Results
Among the 227 tinnitus patients, 60 (26.4%) had comorbid migraine. There were no significant differences in the THI or HHIA/HHIE scores between patients with migraine and those without migraine (both p > 0.05). The HADS score was significantly higher in patients with migraine than those without migraine (p < 0.05).
Out of the 60 tinnitus patients with comorbid migraine, 27 (45.0%) experienced exacerbation of tinnitus during migraine attacks. Patients whose tinnitus exacerbated during migraine attacks had significantly higher scores in THI, HHIA/HHIE, and HADS compared to those whose tinnitus did not change during migraine attacks (p < 0.05 for THI and HADS, p < 0.01 for HHIA/HHIE).

Conclusion
The presence of migraine did not affect the tinnitus-specific HRQOL in tinnitus patients but had significant impacts on their psychiatric comorbidities. However, in patients who experienced exacerbation of tinnitus during migraine attacks, the presence of migraine had a significant impact on the tinnitus-specific HRQOL, hearing handicap, and psychiatric comorbidities.
Feasibility and Outcomes of an Active Osseointegrated Bone Conduction Implant in Children as Young as 5 Years of Age
Authors: Cushing Sharon L. , Goh Samantha , Treble Alexander , Papsin Blake C. , Gordon Karen A. 
Published: August 2024

Introduction
This study reviews the feasibility of implanting active osseointegrated bone conduction devices in young children, below the prior age for FDA indication (<12 years), which has recently been reduced to 5 years. Outcomes included differences in adverse event rates and operative time between two groups (<12 and 12 years or older).

Materials and Methods
This study is a retrospective review of children receiving active osseointegrated bone conduction devices at a tertiary referral center academic hospital. One hundred and twenty-four children received 135 active osseointegrated bone conduction devices (May 2018–March 2024).

Results
Of 135 devices, 77 (57%) were in children <12 years (mean age (SD) = 7.9 (2.0) years, range = 4.9–11.9 years) and 58 (43%) were in 12 years or older (mean age (SD) = 15.1 (1.7) years, range = 12–18 years). Adverse events were significantly higher in the older group, occurring in 8 (10%) of 77 devices in children <12 years and 15 (26%) of 58 devices in children 12 years and older (26%) (Fisher’s exact test = 0.0217 at p < 0.05). Major adverse events occurred in 5/124 (4%) patients, with 2 in patients <12 years (2/73, 3%) and 3 in children 12 and older (3/51, 6%). The proportion of major events between groups was not significantly different (Fisher’s exact test = 0.4, p < 0.05). Mean surgical time was significantly less (t = −2.8799, df = 120.26, p = 0.005) in the children <12 years (mean (SD) = 66.5 (22.4) min) compared to those 12 and over (mean (SD) = 78.32 (23.1) min).

Conclusions
Implantation of active osseointegrated bone conduction devices is feasible in children as young as 5 years and demonstrates low rates of complication. Further miniaturization may allow even earlier safe intervention.
Sound Localization in Active Transcutaneous Bone Conduction Implant Users with Single-Sided Deafness
Authors: Epperson Madison V. , Jones Gerilyn , Abdulrazzak Obada , Anidi Chioma , Ibrahim Nadine , Banakis Hartl Renee 
Published: August 2024

Objective
Evaluate sound localization accuracy of subjects with single-sided deafness (SSD) with active transcutaneous bone conduction implants (atBCIs).

Study Design
Prospective case–control study.

Setting
Tertiary referral center.

Patients
Ten SSD patients (with ATBCIS) and 10 controls.

Interventions
Localization was assessed in a semianechoic chamber using a 24-speaker array. Stimuli included broadband noise (BBN) and narrowband noise (NBN). Perceived stimulus angle was recorded and compared with presented location. Statistical analyses were performed using ANOVA and Wilcoxon rank sum tests.

Main Outcome Measures
The primary outcome measures were as follows: 1) mean angular error (MAE) error (°) and regression slope and 2) subjective benefit assessment (Speech Spatial Qualities questionnaire).

Results
Subjects with SSD demonstrated worse localization by MAE and regression slope compared with controls for both broadband noise (p < 0.0001) and narrowband noise at 500 Hz and 1000 kHz (p < 0.0001). There was no statistically significant difference (p = 0.1090) in slope between all groups at 4000 Hz. There was no significant difference in slope or MAE aided compared with unaided. Localization ability varied widely within the SSD cohort, with some individuals showing some ability in the unaided condition, best at 4000 Hz. Although SSQ confirmed particular difficulty in the spatial hearing domain, all domains improved with device use.

Conclusions
Localization ability for individuals with SSD falls into a somewhat bimodal distribution. Some have fair localization, particularly at high frequencies, that is preserved but not improved with the atBCI. Others have minimal to no localization ability at any frequency, with no apparent device benefit.
Influence of Anatomy-Based Fitting in Cochlear Implant Users on Music Perception Using the Montreal Battery of Evaluation of Amusia
Authors: Heitkötter Felix S. , Krämer Bianca A. , Beule Achim G. , Rudack Claudia 
Published: August 2024

Objectives
The aim is to investigate the influence of the anatomy-based fitting (ABF) in cochlear implants (CI) on the perception of specific musical features.

Design
The Montreal Battery of Evaluation of Amusia (MBEA) test battery was performed with a collective of 16 CI users with and without an anatomy-based fitting and 9 normal hearing subjects. The insertion angles of the intracochlear electrode arrays were calculated using Otoplan® (MED-EL, Innsbruck, Austria) software.

Results
CI users with an anatomy-based fitting achieve better results in the MBEA in all categories, especially in rhythm, meter, and memory. There is no effect of insertion depth alone on the ability to perceive musical features, even after anatomy-based fitting.

Conclusions
The results of the CI users in comparison to normal hearing people confirm previous studies. Apart from better speech understanding in CI users, which has been demonstrated in other studies, the anatomy-based fitting also contributes to a better perception of musical features. Currently, there are no comparable studies on this relationship. Investigations with further parameters with the help of the MBEA are pending.

Significance
Our results show that anatomy-based fitting of cochlear implants significantly improves the perception of specific musical attributes and thus leads to an increased enjoyment of music.