bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Role of Brand Stereotypes in Shaping Consumer Response toward Brands: An Empirical Examination of Direct and Mediating Effects of Warmth and Competence
Authors: Ivens Bjoern S. , Leischnig Alexander , Muller Brigitte , Valta Katharina 
Published: July 2015

ABSTRACTThe purpose of this article is to contribute to the branding literature by examining the critical role of brand stereotypes in shaping consumers’ brand‐related responses. Drawing on the Stereotype Content Model, this article examines how warmth and competence stereotypes impact consumers’ emotional reaction toward brands and in turn consumers’ brand attitudes and behavioral intention. In addition, this article examines how brand stereotypes mediate the relationships between brand personality and consumers’ brand emotions. The results from this study support the dual role of brand stereotypes as relevant predictors of brand emotions, and intervening variables mediating the effects from brand personality perceptions on brand emotions. The findings support the view that mechanisms of social perception apply to brand perception and provide new insights about the relationship between consumers’ brand perceptions and their responses toward brands.
Modeling Consumers’ Adoption Intentions of Remote Mobile Payments in the United Kingdom: Extending UTAUT with Innovativeness, Risk, and Trust
Authors: Slade Emma L. , Dwivedi Yogesh K. , Piercy Niall C. , Williams Michael D. 
Published: July 2015

ABSTRACTMobile payments (MPs) are predicted to be one of the future's most successful mobile services but have achieved limited acceptance in developed countries to date. PCs are still the preferred technology for online shopping in the United Kingdom but the continued growth of mobile commerce (MC) is highly correlated with the success of remote MPs (RMPs). Currently MP research has largely ignored the variations between different MP solutions, and existing MP adoption studies have predominantly utilized Davis’ (1989) Technology Acceptance Model, which has been criticized for having a deterministic approach without much consideration for users’ individual characteristics. Therefore, this study applied the Unified Theory of Acceptance and Use of Technology (UTAUT), extended with more consumer‐related constructs, to explore the factors affecting nonusers’ intentions to adopt RMP in the United Kingdom. Quantitative data were collected (n = 268) and structural equation modeling was undertaken. The findings revealed that performance expectancy, social influence, innovativeness, and perceived risk significantly influenced nonusers’ intentions to adopt RMP, whereas effort expectancy did not. Inclusion of MP knowledge as a moderating variable revealed that there was a significant difference in the effect of trust on behavioral intention for those who knew about MP than for those who did not. These findings have important theoretical and practical implications, particularly for the development and marketing of RMP, which will support the long‐term success of MC.
Validation of the 1290 MHz wind profiler at Payerne, Switzerland, using radiosonde GPS wind measurements
Authors: Haefele A. , Ruffieux D. 
Published: July 2015

ABSTRACTThe validation of a 1290 MHz wind profiler using 3 years of collocated wind profiler and radiosonde wind measurements is presented. The radiosonde wind information is derived from global positioning system data and is vertically averaged to match the vertical resolution of the wind profiler measurements. The integration period of the wind profiler is chosen such that it is centred around the radiosonde measurement time. Periods where bird migration must be expected have been systematically excluded. The standard deviation of the differences between wind profiler and radiosonde in the wind components u and v is between 1.75 and 2 m s−1 and the bias is smaller than 0.75 m s−1 for heights below 6 km for both modes. Some part of the obtained standard deviation can be explained by the fact that radiosonde and wind profiler measurements are not representative for each other. In order to reduce the representativeness error, a subset of cases has been selected, for which the wind field was stationary during the measurement period and uniform across the sampled volume of the wind profiler. The standard deviation derived from the subset is between 1 and 1.5 m s−1 while the bias changes only little. This reduction can be attributed to a reduction in the representativeness error and in the retrieval error of the wind profiler since atmospheric homogeneity is a basic assumption in the wind retrieval. The obtained value of 1.5 m s−1 can be taken as an upper limit of the measurement uncertainty of the wind profiler in favourable measurement conditions.
The ImageJ ecosystem: An open platform for biomedical image analysis
Authors: Schindelin Johannes , Rueden Curtis T. , Hiner Mark C. , Eliceiri Kevin W. 
Published: July 2015

SUMMARYTechnology in microscopy advances rapidly, enabling increasingly affordable, faster, and more precise quantitative biomedical imaging, which necessitates correspondingly more‐advanced image processing and analysis techniques. A wide range of software is available—from commercial to academic, special‐purpose to Swiss army knife, small to large—but a key characteristic of software that is suitable for scientific inquiry is its accessibility. Open‐source software is ideal for scientific endeavors because it can be freely inspected, modified, and redistributed; in particular, the open‐software platform ImageJ has had a huge impact on the life sciences, and continues to do so. From its inception, ImageJ has grown significantly due largely to being freely available and its vibrant and helpful user community. Scientists as diverse as interested hobbyists, technical assistants, students, scientific staff, and advanced biology researchers use ImageJ on a daily basis, and exchange knowledge via its dedicated mailing list. Uses of ImageJ range from data visualization and teaching to advanced image processing and statistical analysis. The software's extensibility continues to attract biologists at all career stages as well as computer scientists who wish to effectively implement specific image‐processing algorithms. In this review, we use the ImageJ project as a case study of how open‐source software fosters its suites of software tools, making multitudes of image‐analysis technology easily accessible to the scientific community. We specifically explore what makes ImageJ so popular, how it impacts the life sciences, how it inspires other projects, and how it is self‐influenced by coevolving projects within the ImageJ ecosystem. Mol. Reprod. Dev. 82: 518–529, 2015. © 2015 Wiley Periodicals, Inc.
Improved dynamic parallel imaging coil calibration method robust to respiratory motion with application to first‐pass contrast‐enhanced myocardial perfusion imaging
Authors: Fair Merlin J. , Gatehouse Peter D. , Drivas Peter , Firmin David N. 
Published: July 2015

PurposeTo develop an accurate method of performing free‐breathing coil calibration for application to parallel imaging reconstructions of dynamic single‐shot datasets.MethodsCoil calibration data are produced through acquisition of multiple prescans before the accelerated scan, applied during free‐breathing. These multiple free‐breathing prescans (MFPs) provide the necessary coil information for accurate parallel imaging reconstruction of each accelerated frame of a dynamic series, under guidance of an appropriate respiratory position based matching algorithm. This is investigated in myocardial first‐pass perfusion with retrospectively undersampled datasets for analysis with standard calibration techniques to guide prospectively undersampled experiments for specific demonstration of performance against a range of “temporal” calibration techniques.ResultsReconstruction of the retrospectively subsampled datasets with MFP‐calibrated parallel imaging showed significant improvements in relative root‐mean‐square error comparative to all other techniques (all P < 0.05; n = 6) for acceleration factors R > 3. Accelerated acquisitions, reconstructed by means of various temporal calibration techniques and analyzed by visual observer artifact scoring, also demonstrated a large improvement with use of MFPs. Artifact levels were reduced from an average of 2.5 ± 0.6 for the best performing implementation of TGRAPPA to 0.8 ± 0.4 for MFP‐GRAPPA (P < 0.001; n = 20) (0 = none to 4 = strong, nondiagnostic).ConclusionMFP as parallel imaging coil calibration data can give improved performance in free‐breathing dynamic MR while maintaining maximal acceleration. Magn Reson Med 75:2315–2323, 2016. © 2015 Wiley Periodicals, Inc.
Improved spoiling efficiency in dynamic RF‐spoiled imaging by ghost phase modulation and temporal filtering
Authors: Nielsen Jon‐Fredrik , Noll Douglas C. 
Published: July 2015

PurposeRadiofrequency‐spoiled steady‐state sequences offer rapid data acquisition with T1‐ or T2*‐weighting. The spoiler gradients in these sequences must be large enough to suppress ghost artifacts, and are chosen empirically. However, certain factors such as the need to minimize gradient first moments or acoustic noise can limit the spoiler size and, hence, the ability to suppress ghosts. We present an acquisition and preprocessing strategy for improved spoiling efficiency in conventional and echo‐shifted dynamic radiofrequency‐spoiled 3D imaging.Theory and MethodsBy requiring each time‐frame in a dynamic imaging sequence to contain a particular (restricted) number of total radiofrequency shots, the ghost signal can be made to alternate in sign every other frame. The ghost is then suppressed by Fourier transforming along the temporal dimension, and removing the Nyquist frequency in preprocessing (similar to UNFOLD). The method works for both Cartesian and non‐Cartesian imaging.ResultsWe demonstrate improved ghost suppression with the proposed approach, for both conventional and echo‐shifted spoiled gradient echo imaging in stationary phantoms and in vivo. Cartesian echo‐shifted spoiled gradient echo imaging produces two ghosts shifted in opposite directions, both of which are suppressed with our method.ConclusionFor a given spoiler gradient area, the proposed approach substantially suppresses the ghost signal in both conventional and echo‐shifted dynamic radiofrequency‐spoiled imaging. Magn Reson Med 75:2388–2393, 2016. © 2015 Wiley Periodicals, Inc.
A well‐conditioned and optimally convergent XFEM for 3D linear elastic fracture
Authors: Agathos Konstantinos , Chatzi Eleni , Bordas Stéphane P. A. , Talaslidis Demosthenes 
Published: July 2015

SummaryA variation of the extended finite element method for three‐dimensional fracture mechanics is proposed. It utilizes a novel form of enrichment and point‐wise and integral matching of displacements of the standard and enriched elements in order to achieve higher accuracy, optimal convergence rates, and improved conditioning for two‐dimensional and three‐dimensional crack problems. A bespoke benchmark problem is introduced to determine the method's accuracy in the general three‐dimensional case where it is demonstrated that the proposed approach improves the accuracy and reduces the number of iterations required for the iterative solution of the resulting system of equations by 40% for moderately refined meshes and topological enrichment. Moreover, when a fixed enrichment volume is used, the number of iterations required grows at a rate which is reduced by a factor of 2 compared with standard extended finite element method, diminishing the number of iterations by almost one order of magnitude. Copyright © 2015 John Wiley & Sons, Ltd.
Initial testing (stage 1) of the anti‐microtubule agents cabazitaxel and docetaxel, by the Pediatric Preclinical Testing Program
Authors: Reynolds C. Patrick , Kang Min H. , Maris John M. , Kolb E. Anders , Gorlick Richard , Wu Jianrong , Kurmasheva Raushan T. , Houghton Peter J. , Smith Malcolm A. 
Published: July 2015

BackgroundAlthough microtubule‐destabilizing agents (principally vincristine) are in common use in pediatric oncology, the microtubule‐stabilizing taxanes are uncommonly used to treat childhood cancers. Cabazitaxel has been reported to have activity superior to that of docetaxel in preclinical models of multidrug‐resistant adult cancers, and it was active in patients who had progressed on or after docetaxel. The PPTP conducted a comparison of these two agents against the PPTP in vitro panel and against a limited panel of solid tumor xenografts.ProceduresCabazitaxel and docetaxel were tested against the PPTP in vitro cell line panel at concentrations from 0.01 to 0.1 μM and in vivo against a subset of the PPTP solid tumor xenograft models at a dose of 10 or 7.5 mg/kg on an every 4 days × 3 I.V. schedule.ResultsIn vitro, both cabazitaxel and docetaxel had similar potency (median rIC50 0.47 nM and 0.88 nM, respectively) and a similar activity profile, with Ewing sarcoma cells being significantly more sensitive to both agents. In vitro sensitivity to docetaxel inversely correlated with mRNA expression for ABCB1, but the correlation with ABCB1 expression was weaker for cabazitaxel. In vivo cabazitaxel demonstrated significantly greater activity than docetaxel in five of 12 tumor models, inducing regressions in six models compared with three models for docetaxel.ConclusionsCabazitaxel demonstrated superior activity compared to docetaxel. The lower cabazitaxel systemic exposure tolerated in humans compared to mice needs to be considered when extrapolating these results to the clinical setting. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Treatment of young children with CNS‐positive acute lymphoblastic leukemia without cranial radiotherapy
Authors: Wilejto Marta , Giuseppe Giancarlo Di , Hitzler Johann , Gupta Sumit , Abla Oussama 
Published: July 2015

BackgroundDue to the long‐term sequelae of cranial radiotherapy (CRT), contemporary treatment protocols for children with acute lymphoblastic leukemia (ALL) aim to limit the use of prophylactic CRT. For patients with central nervous system (CNS) involvement with ALL at diagnosis, the use of CRT remains common. Children <5 years of age are a particularly challenging subgroup in whom the consequences of CRT can be devastating.ProcedureThis study retrospectively describes the overall (OS) and event‐free survival (EFS) of young children (1–5 years) who were treated for CNS‐positive ALL at the Hospital for Sick Children between 2000 and 2013.ResultsOf a total of 19 patients, two were treated with upfront CRT, both as part of the conditioning regimen prior to HSCT. All patients received intensification of CNS‐directed chemotherapy by triple intra‐thecal chemotherapy (84.2%), use of dexamethasone in induction (57.9%) and maintenance (66.7%), and high‐dose methotrexate (77.8%). The OS was 84.2 ± 8.4% and EFS was 79.0 ± 9.4% with a median follow‐up time of 4.3 years (range, 2.6–8.2). The cumulative incidence of CNS relapse was 5.2 ± 5.1%.ConclusionsWe conclude that omission of CRT from the treatment of young children with ALL involving the CNS is associated with acceptable survival and avoids potentially devastating late effects in this group. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Das Heliumionen‐Mikroskop
Authors: Vieker Henning , Frese Natalie , Gölzhäuser Armin 
Published: July 2015

AbstractDas Heliumionen‐Mikroskop (HIM) rastert Proben mit einem Strahl aus Heliumionen ab. Gegenüber der etablierten Raster‐Elektronenmikroskopie (REM) bietet es einige Vorteile: höhere Auflösung, höhere Oberflächensensitivität, empfindlichere Kontrastmechanismen, größere Tiefenschärfe und geringere Probenschädigung. Hinzu kommt bei elektrisch isolierenden Proben die Möglichkeit einer Ladungskompensation, die eine elektrostatische Aufladung der Proben verhindert. In konventioneller REM müssen solche Proben mit einer leitfähigen Schicht bedampft werden, die aber feine Oberflächenstrukturen überdeckt. Seine vielen Vorzüge könnten das HIM zu einer Alternative für das REM machen, die in manchen Anwendungen sogar überlegen sein könnte.
Magnetische Speicher: Schalten mit Licht
Authors: Alebrand Sabine , Cinchetti Mirko , Aeschlimann Martin 
Published: July 2015

Abstract2007 wurde entdeckt, dass die Magnetisierungsrichtung einer ferrimagnetischen GdFeCo‐Legierung allein durch einen zirkular polarisierten ultrakurzen Laserpuls stabil umgekehrt werden kann. Dies funktioniert ohne angelegtes Magnetfeld. Fast acht Jahre nach dieser Entdeckung wissen wir nun, dass der Effekt auch in Ferromagneten auftreten kann. Er ist somit doch weitaus allgemeiner als ursprünglich angenommen. Das erhöht sein Potenzial für mögliche Anwendungen in der Speichertechnologie deutlich. Trotz allem bleibt aber die mikroskopische Ursache des All‐optical Switchings weiter ungeklärt.
Wie ein Band zur Fontäne wird
Authors: Schlichting Hans Joachim 
Published: July 2015

AbstractÄhnlich wie eine fallende Kugelkette kann man flache Seile in Form von Textil‐ oder Kunststoffbändern dazu bringen, sich fontänenartig aus einem Behälter heraus zu erheben. Anders als bei der Kugelkette müssen die Bänder rosettenartig gefaltet in den Becher gelegt werden.
Low‐potential facile electrosynthesis of free‐standing poly(1H‐benzo[g]indole) film as a yellow‐light‐emitter
Authors: Wang Ling , Zhao Dan , Liu Changlong , Nie Guangming 
Published: July 2015

ABSTRACTHigh‐quality free‐standing poly(1H‐benzo[g]indole) (PBIn) films were synthesized electrochemically by direct anodic oxidation of 1H‐benzo[g]indole (BIn) in boron trifluoride diethyl etherate. PBIn films obtained from this medium showed good electrochemical behavior and better thermal stability with a conductivity of 0.29 S cm−1. PBIn films with low band gap value (1.59 eV) were insoluble in acetone and tetrahydrofuran. The structure and morphology of the polymer were studied by UV–vis, FTIR, and scanning electron microscopy, respectively. The results of quantum chemistry calculations and the spectroscopies of dedoped PBIn indicate that the polymerization of BIn mainly occurs via C(2) and C(5) position. The polymer film was compact with regular nanoparticles on the surface. Fluorescent spectral studies indicate that solid‐state PBIn film is a good yellow‐light‐emitter. Thermal stability of PBIn film is higher than poly(indole‐6‐carboxylic acid), poly(5‐formylindole), and polyindole. To the best of our knowledge, this is the first report on the electrosynthesis of free‐standing polyindole derivatives as yellow‐light‐emitter. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 2730–2738
The putative P‐gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P‐glycoprotein expressing cell line MDCK II MDR1
Authors: Saaby Lasse , Tfelt‐Hansen Peer , Brodin Birger 
Published: July 2015

AbstractVerapamil is used in high doses for the treatment of cluster headache. Verapamil has been described as a P‐glycoprotein (P‐gp, ABCB1) substrate. We wished to evaluate in vitro whether co administration of a P‐gp inhibitor with verapamil could be a feasible strategy for increasing CNS uptake of verapamil. Fluxes of radiolabelled verapamil across MDCK II MDR1 monolayers were measured in the absence and presence of the putative P‐gp inhibitor telmisartan (a clinically approved drug compound). Verapamil displayed a vectorial basolateral‐to‐apical transepithelial efflux across the MDCK II MDR1 monolayers with a permeability of 5.7 × 10−5 cm sec−1 compared to an apical to basolateral permeability of 1.3 × 10−5 cm sec‐1. The efflux could be inhibited with the P‐gp inhibitor zosuquidar. Zosuquidar (0.4 μmol/L) reduced the efflux ratio (PB‐A/PA‐B) for verapamil 4.6–1.6. The presence of telmisartan, however, only caused a slight reduction in P‐gp‐mediated verapamil transport to an efflux ratio of 3.4. Overall, the results of the present in vitro approach indicate, that clinical use of telmisartan as a P‐gp inhibitor may not be an effective strategy for increasing brain uptake of verapamil by co‐administration with telmisartan.
Increased efficacy of VX‐809 in different cellular systems results from an early stabilization effect of F508del‐CFTR
Authors: Farinha Carlos M. , Sousa Marisa , Canato Sara , Schmidt André , Uliyakina Inna , Amaral Margarida D. 
Published: July 2015

AbstractCystic fibrosis (CF), the most common recessive autosomal disease among Caucasians, is caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein. The most common mutation, F508del, leads to CFTR impaired plasma membrane trafficking. Therapies modulating CFTR basic defect are emerging, such as VX‐809, a corrector of F508del‐CFTR traffic which just succeeded in a Phase III clinical trial. We recently showed that VX‐809 is additive to two other correctors (VRT‐325 and compound 4a). Here, we aimed to determine whether the differential rescuing by these compounds results from cell‐specific factors or rather from distinct effects at the early biogenesis and/or processing. The rescuing efficiencies of the above three correctors were first compared in different cellular models (primary respiratory cells, cystic fibrosis bronchial epithelial and baby hamster kidney [BHK] cell lines) by functional approaches: micro‐Ussing chamber and iodide efflux. Next, biochemical methods (metabolic labeling, pulse‐chase and immunoprecipitation) were used to determine their impact on CFTR biogenesis / processing. Functional analyses revealed that VX‐809 has the greatest rescuing efficacy and that the relative efficiencies of the three compounds are essentially maintained in all three cellular models tested. Nevertheless, biochemical data show that VX‐809 significantly stabilizes F508del‐CFTR immature form, an effect that is not observed for C3 nor C4. VX‐809 and C3 also significantly increase accumulation of immature CFTR. Our data suggest that VX‐809 increases the stability of F508del‐CFTR immature form at an early phase of its biogenesis, thus explaining its increased efficacy when inducing its rescue.
Propofol restores TRPV1 sensitivity via a TRPA1‐, nitric oxide synthase‐dependent activation of PKCε
Authors: Sinharoy Pritam , Zhang Hongyu , Sinha Sayantani , Prudner Bethany C. , Bratz Ian N. , Damron Derek S. 
Published: July 2015

AbstractWe previously demonstrated that the intravenous anesthetic, propofol, restores the sensitivity of transient receptor potential vanilloid channel subtype‐1 (TRPV1) receptors via a protein kinase C epsilon (PKCε)‐dependent and transient receptor potential ankyrin channel subtype‐1 (TRPA1)‐dependent pathway in sensory neurons. The extent to which the two pathways are directly linked or operating in parallel has not been determined. Using a molecular approach, our objectives of the current study were to confirm that TRPA1 activation directly results in PKCε activation and to elucidate the cellular mechanism by which this occurs. F‐11 cells were transfected with complimentary DNA (cDNA) for TRPV1 only or both TRPV1 and TRPA1. Intracellular Ca2+ concentration was measured in individual cells via fluorescence microscopy. An immunoblot analysis of the total and phosphorylated forms of PKCε, nitric oxide synthase (nNOS), and TRPV1 was also performed. In F‐11 cells containing both channels, PKCε inhibition prevented the propofol‐ and allyl isothiocyanate (AITC)‐induced restoration of TRPV1 sensitivity to agonist stimulation as well as increased phosphorylation of PKCε and TRPV1. In cells containing TRPV1 only, neither agonist induced PKCε or TRPV1 phosphorylation. Moreover, NOS inhibition blocked propofol‐and AITC‐induced restoration of TRPV1 sensitivity and PKCε phosphorylation, and PKCε inhibition prevented the nitric oxide donor, SNAP, from restoring TRPV1 sensitivity. Also, propofol‐and AITC‐induced phosphorylation of nNOS and nitric oxide (NO) production were blocked with the TRPA1‐antagonist, HC‐030031. These data indicate that the AITC‐ and propofol‐induced restoration of TRPV1 sensitivity is mediated by a TRPA1‐dependent, nitric oxide synthase‐dependent activation of PKCε.