bluuebunny/crossref_metadata_2025_split huggingface dataset:
The BstUI and DpnII Variants of the COL5A1 Gene Are Associated With Tennis Elbow
Authors: Altinisik Julide , Meric Gokhan , Erduran Mehmet , Ates Omer , Ulusal Ali Engin , Akseki Devrim 
Published: April 2015

Background: Tennis elbow entails pain and tenderness over the lateral epicondyle. The exact cause of the condition is not fully understood. Type V collagen is a minor fibrillar collagen that intercalates with type I collagen and forms collagen fibrils. It is encoded by the COL5A1 gene. Sequence variants within COL5A1 3′-UTR have been implicated in musculoskeletal diseases. Purpose: To determine whether rs12722 (BstUI C414T polymorphism) and rs13946 (DpnII C230T polymorphism) of the COL5A1 gene are associated with an increased risk of tennis elbow. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 152 patients with tennis elbow and 195 healthy participants were enrolled in this study. The rs12722 (BstUI C414T) and rs13946 (DpnII C230T) polymorphisms were investigated with the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method. Results: There was a significant difference in both BstUI and DpnII genotype frequencies between patients with tennis elbow and healthy participants. The A2 allele of BstUI and the B1 allele of DpnII were significantly underrepresented in the patient group. Conclusion: Individuals with the BstUI A1 allele and DpnII B2 allele of the COL5A1 gene have a high likelihood of developing symptoms of the tennis elbow. This is the first study reporting that rs12722 and rs13946 SNPs (single nucleotide polymorphisms) are genetic risk factors for tennis elbow.
Why Patients Do Not Participate in Sports Activities After Total Knee Arthroplasty
Authors: Chang Moon Jong , Kang Yeon Gwi , Chung Byung June , Chang Chong Bum , Kim Tae Kyun 
Published: April 2015

Background It is important to identify the reasons or factors preventing patients from participating in sports activities after total knee arthroplasty (TKA) to improve patient satisfaction and general health that can be gained from regular sports activities. Purpose To determine the reasons for lack of participation in regular sports activities after TKA as perceived by patients and to identify specific factors involved. Study Design Case series; Level of evidence, 4. Methods A total of 369 patients with a follow-up longer than 1 year after TKA were included in this retrospective study. A postal survey regarding sports activities was conducted using a questionnaire gathering information such as sociodemographic data, activity levels, and sports activities after TKA. The reasons perceived by patients for not participating in sports activities were determined. Patients unable to participate in sports activities were compared with patients able to do so in terms of sociodemographic data and pre- and postoperative outcomes. Results Of the 369 patients, 88 (24%) replied that they could not participate in a sports activity. Among the perceived reasons, reasons not related to the replaced knee were more frequent than those related to the replaced knee (76% vs 24%). Symptoms related to the spine or other joints composed 25% of the total perceived reasons. The presence of medical comorbidities accounted for 16%, while symptoms in the nonreplaced knee represented 8% of the reasons. In terms of patient factors, multivariate logistic regression revealed that male sex, a floor-based (ie, non-Western) lifestyle with greater demands on knee flexion, and worse postoperative University of California at Los Angeles activity scale were associated with nonregular sports activity levels. Conclusion The perceived reasons and patient factors hindering regular sports activities after TKA were not restricted to problems with the replaced knee. Nonetheless, orthopaedic surgeons may have a substantial role in encouraging patients to participate in sports by resolving joint-related problems. Furthermore, this study supports the notion that a multidisciplinary approach is needed to improve sports participation after surgery.
Platelets and platelet-derived factor Va confer hemostatic competence in complete factor V deficiency
Authors: Bouchard Beth A. , Chapin John , Brummel-Ziedins Kathleen E. , Durda Peter , Key Nigel S. , Tracy Paula B. 
Published: April 2015

Key PointsAdministration of plasma to a factor V–deficient individual yields a stable platelet factor V/Va pool derived from megakaryocyte endocytosis. Platelets and platelet-derived factor V/Va promote and extend hemostasis well after depletion of the plasma-derived factor V pool.
Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells
Authors: Xia Wenzheng , Zhang Fengyun , Xie Congying , Jiang Miaomiao , Hou Meng 
Published: April 2015

Abstract
Introduction
Mesenchymal stem cells (MSCs)-based therapies have had positive outcomes in animal models of cardiovascular diseases. However, the number and function of MSCs decline with age, reducing their ability to contribute to endogenous injury repair. The potential of stem cells to restore damaged tissue in older individuals can be improved by specific pretreatment aimed at delaying senescence and improving their regenerative properties. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that modulates age-related signaling pathways, and hence is a good candidate for rejuvenative function.

Methods
Bone marrow-derived mesenchymal stem cells (BM-MSCs) were isolated from young (6-month-old) or aged (24-month-old) male donor rats. Cell proliferation was measured using the CCK8 cell proliferation assay; secretion of VEGF, bFGF, HGF, and IGF was assessed by RT-qPCR and ELISA. Apoptosis was induced by hypoxia and serum deprivation (hypoxia/SD) for up to 6 hr, and examined by flow cytometry. Expression levels of AMP-activated protein kinase (AMPK) and forkhead box class O 3a (FOXO3a) were detected by Western blotting. CD74 expression was assayed using RT-qPCR, Western blotting, and immunofluorescence.

Results
In this study, we found that MSCs isolated from the bone marrow of aged rats displayed reduced proliferative capacity, impaired ability to mediate paracrine signaling, and lower resistance to hypoxia/serum deprivation-induced apoptosis, when compared to younger MSCs. Interestingly, pretreatment of aged MSCs with MIF enhanced their growth, paracrine function and survival. We detected enhanced secretion of VEGF, bFGF, HGF, and IGF from MIF-treated MSCs using ELISA. Finally, we show that hypoxia/serum deprivation-induced apoptosis is inhibited in aged MSCs following MIF exposure. Next, we found that the mechanism underlying the rejuvenating function of MIF involves increased CD74-dependent phosphorylation of AMPK and FOXO3a. Furthermore, this effect was abolished when CD74, AMPK, or FOXO3a expression was silenced using small-interfering RNAs(siRNA).

Conclusions
MIF can rejuvenate MSCs from a state of age-induced senescence by interacting with CD74 and subsequently activating AMPK-FOXO3a signaling pathways. Pretreatment of MSCs with MIF may have important therapeutic implications in restoration or rejuvenation of endogenous bone marrow-MSCs in aged individuals.
A new iterative process for a hybrid pair of generalized asymptotically nonexpansive single-valued and generalized nonexpansive multi-valued mappings in Banach spaces
Authors: Suantai Suthep , Phuengrattana Withun 
Published: April 2015

AbstractIn this paper, we construct an iterative process involving a hybrid pair of a finite family of generalized asymptotically nonexpansive single-valued mappings and a finite family of generalized nonexpansive multi-valued mappings and prove weak and strong convergence theorems of the proposed iterative process in Banach spaces. Our main results extend and generalize many results in the literature.
Reich type weak contractions on metric spaces endowed with a graph
Authors: Phon-on Aniruth , Sama-Ae Areeyuth , Makaje Nifatamah , Riyapan Pakwan 
Published: April 2015

AbstractIn this paper, we define a new class of Reich type multi-valued contractions on a complete metric space satisfying the g-graph preserving condition and we study the fixed point theorem for such mappings. In addition, we present the existence and uniqueness of the fixed point for at least one of two multi-valued mappings. The results of this paper extend and generalize several well-known results. Some examples illustrate the usability of our results.
How effective are on-farm conservation land management strategies for preserving ecosystem services in developing countries? A systematic map protocol
Authors: Thorn Jessica , Snaddon Jake , Waldron Anthony , Kok Kasper , Zhou Wen , Bhagwat Shonil , Willis Kathy , Petrokofsky Gillian 
Published: April 2015

Abstract
Background
An extensive body of literature in the field of agro-ecology claims to show the positive effects that maintenance of ecosystem services can have on sustainably meeting future food demand, by making farms more productive and resilient, and contributing to better nutrition and livelihoods of farmers. In Africa alone, some research has estimated a two-fold yield increase if food producers capitalize on new and existing knowledge from science and technology. Site-specific strategies adopted with the aim of improving ecosystem services may incorporate principles of multifunctional agriculture, sustainable intensification and conservation agriculture. However, a coherent synthesis and review of the evidence of these claims is largely absent, and the quality of much of this literature is questionable. Moreover, inconsistent effects have commonly been reported, while empirical evidence to support assumed improvements is largely lacking.

Objectives
This systematic map is stimulated by an interest to (1) collate evidence on the effectiveness of on-farm conservation land management for preserving and enhancing ecosystem services in agricultural landscapes, by drawing together the currently fragmented and multidisciplinary literature base, and (2) geographically map what indicators have been used to assess on-farm conservation land management. For both questions, we will focus on 74 low-income and developing countries, where much of the world’s agricultural expansion is occurring, yet 80% of arable land is already used and croplands are yielding well below their potential.

Methods/Design
To this end, reviewers will systematically search bibliographic databases for peer-reviewed research from Web of Science, SCOPUS, AGRICOLA, AGRIS databases and CAB abstracts, and grey literature from Google Scholar, and 22 subject-specific or institutional websites. Boolean search operators will be used to create search strings where applicable. Ecosystem services included in the study are pollination services; pest-, carbon-, soil-, and water-regulation; nutrient cycling; medicinal and aromatic plants; fuel wood and cultural services. Outputs of the systematic map will include a database, technical report and an online interactive map, searchable by topic. The results of this map are expected to provide clarity about synergistic outcomes of conservation land management, which will help support local decision-making.
Randomized Phase III Trial Comparing ABVD Plus Radiotherapy With the Stanford V Regimen in Patients With Stages I or II Locally Extensive, Bulky Mediastinal Hodgkin Lymphoma: A Subset Analysis of the North American Intergroup E2496 Trial
Authors: Advani Ranjana H. , Hong Fangxin , Fisher Richard I. , Bartlett Nancy L. , Robinson K. Sue , Gascoyne Randy D. , Wagner Henry , Stiff Patrick J. , Cheson Bruce D. , Stewart Douglas A. , Gordon Leo I. , Kahl Brad S. , Friedberg Jonathan W. , Blum Kristie A. , Habermann Thomas M. , Tuscano Joseph M. , Hoppe Richard T. , Horning Sandra J. 
Published: April 2015

PurposeThe phase III North American Intergroup E2496 Trial (Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma) compared doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) with mechlorethamine, doxorubicin, vincristine, bleomycin, vinblastine, etoposide, and prednisone (Stanford V). We report results of a planned subgroup analysis in patients with stage I or II bulky mediastinal Hodgkin lymphoma (HL).Patients and MethodsPatients were randomly assigned to six to eight cycles of ABVD every 28 days or Stanford V once per week for 12 weeks. Two to 3 weeks after completion of chemotherapy, all patients received 36 Gy of modified involved field radiotherapy (IFRT) to the mediastinum, hila, and supraclavicular regions. Patients on the Stanford V arm received IFRT to additional sites ≥ 5 cm at diagnosis. Primary end points were failure-free survival (FFS) and overall survival (OS).ResultsOf 794 eligible patients, 264 had stage I or II bulky disease, 135 received ABVD, and 129 received Stanford V. Patient characteristics were matched. The overall response rate was 83% with ABVD and 88% with Stanford V. At a median follow-up of 6.5 years, the study excluded a difference of more than 21% in 5-year FFS and more than 16% in 5-year OS between ABVD and Stanford V (5-year FFS: 85% v 79%; HR, 0.68; 95% CI, 0.37 to 1.25; P = .22; 5-year OS: 96% v 92%; HR, 0.49; 95% CI, 0.16 to 1.47; P = .19). In-field relapses occurred in < 10% of the patients in each arm.ConclusionFor patients with stage I or II bulky mediastinal HL, no substantial statistically significant differences were detected between the two regimens, although power was limited. To the best of our knowledge, this is the first prospective trial reporting outcomes specific to this subgroup, and it sets a benchmark for comparison of ongoing and future studies.
Donepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial
Authors: Rapp Stephen R. , Case L. Doug , Peiffer Ann , Naughton Michelle M. , Chan Michael D. , Stieber Volker W. , Moore Dennis F. , Falchuk Steven C. , Piephoff James V. , Edenfield William J. , Giguere Jeffrey K. , Loghin Monica E. , Shaw Edward G. 
Published: April 2015

Purpose Neurotoxic effects of brain irradiation include cognitive impairment in 50% to 90% of patients. Prior studies have suggested that donepezil, a neurotransmitter modulator, may improve cognitive function. Patients and Methods A total of 198 adult brain tumor survivors ≥ 6 months after partial- or whole-brain irradiation were randomly assigned to receive a single daily dose (5 mg for 6 weeks, 10 mg for 18 weeks) of donepezil or placebo. A cognitive test battery assessing memory, attention, language, visuomotor, verbal fluency, and executive functions was administered before random assignment and at 12 and 24 weeks. A cognitive composite score (primary outcome) and individual cognitive domains were evaluated. Results Of this mostly middle-age, married, non-Hispanic white sample, 66% had primary brain tumors, 27% had brain metastases, and 8% underwent prophylactic cranial irradiation. After 24 weeks of treatment, the composite scores did not differ significantly between groups (P = .48); however, significant differences favoring donepezil were observed for memory (recognition, P = .027; discrimination, P = .007) and motor speed and dexterity (P = .016). Significant interactions between pretreatment cognitive function and treatment were found for cognitive composite (P = .01), immediate recall (P = .05), delayed recall (P = .004), attention (P = .01), visuomotor skills (P = .02), and motor speed and dexterity (P < .001), with the benefits of donepezil greater for those who were more cognitively impaired before study treatment. Conclusion Treatment with donepezil did not significantly improve the overall composite score, but it did result in modest improvements in several cognitive functions, especially among patients with greater pretreatment impairments.
Personality traits of drivers serving a custodial sentence for drink driving
Authors: Pawłowska Beata , Rzeszutko Ewa 
Published: April 2015

CelCelem pracy była analiza cech osobowości mężczyzn odbywających karę pozbawiania wolności za prowadzenie pojazdu w stanie nietrzeźwości.MetodaBadaniami objęto 44 mężczyzn odbywających karę pozbawienia wolności za prowadzenie samochodu w stanie nietrzeźwości, 45 mężczyzn odbywających karę pozbawienia wolności za rozboje i pobicia oraz 32 mężczyzn niekaranych, którzy nigdy nie prowadzili samochodu pod wpływem alkoholu.
W pracy zastosowano następujące metody badawcze: Ankietę socjodemograficzną własnej konstrukcji, Kwestionariusz Radzenia Sobie ze Stresem Janke, Erdmanna, Boucsein, Arkusz Samooceny Cattella, Kwestionariusz Narcyzmu Deneke, Hilgenstock, Müller, Test Przymiotnikowy ACL Gougha i Heilbruna, w polskim opracowaniu Płużek oraz Kwestionariusz Trzebińskiej Styl Życia.WynikiOtrzymane wyniki wskazują na istotne różnice między mężczyznami odbywającymi karę pozbawiania wolności za prowadzenie samochodu w stanie nietrzeźwości a mężczyznami z grupy kontrolnej w zakresie sposobów radzenia sobie ze stresem, poziomu niepokoju i cech osobowości antyspołecznej.Wnioski1. Mężczyzn odbywających karę pozbawienia wolności za prowadzenie pojazdu w stanie nietrzeźwości charakteryzują istotnie bardziej nasilone cechy osobowości antyspołecznej, wyższy poziom niepokoju, nasilona impulsywność, drażliwość, nieufność, agresja, egocentryzm, ekscentryczność, nasilona potrzeba uzyskania uznania, łamania norm społecznych, doświadczania różnorodności bodźców, nowych wrażeń, większe trudności przystosowawcze, mniejsza samodyscyplina, mniejsze poczucie własnej wartości oraz częściej stosowane destrukcyjne, ucieczkowe i emocjonalne sposoby radzenia sobie ze stresem w porównaniu od osób niekaranych, które nigdy nie prowadziły pojazdu pod wpływem alkoholu.
2. W zakresie nasilenia cech zaburzeń osobowości, sposobów radzenia sobie ze stresem oraz obrazu siebie nie stwierdzono istotnych różnic między mężczyznami odbywającymi karę pozbawienia wolności za prowadzenie pojazdu mechanicznego w stanie nietrzeźwości a mężczyznami odbywającymi karę pozbawienia wolności za rozboje z pobiciem.
The role of a psychiatrist in treatment and recovery process of persons suffering from schizophrenia.
Authors: Sawicka Maryla , Charzyńska Katarzyna 
Published: April 2015

CelWyniki badań wskazują, że możliwość zbudowania związku terapeutycznego w leczeniu schizofrenii sprzyja lepszemu funkcjonowaniu, skuteczniejszemu obniżeniu objawów psychotycznych oraz realizacji celów osobistych pacjentów. Celem obecnej pracy było sprawdzenie, czy pacjenci systematycznie współpracujący z psychiatrami są bardziej skrupulatni w przestrzeganiu zaleceń lekarskich oraz czy lepiej funkcjonują społecznie i klinicznie w porównaniu z pacjentami niewspółpracującymi.MetodaDo badania włączono 300 pacjentów ze schizofrenią. Pacjenci zostali podzieleni na 2 grupy: grupa właściwa – pacjenci systematycznie współpracujący z lekarzem, oraz grupa kontrolna – pacjenci niewspółpracujący. Dane zostały zebrane w trakcie jednorazowego wywiadu przy wykorzystaniu Kwestionariusza Oceny Leczenia Farmakologicznego, Skali Satysfakcji z Życia, Skali Kontroli Emocji, Testu Orientacji Życiowej, Skali Uogólnionej Własnej Skuteczności, Skali Pozytywnych i Negatywnych Objawów Schizofrenii oraz kwestionariusza danych społeczno- demograficznych.WynikiPacjenci systematycznie współpracujący z psychiatrami w porównaniu z pacjentami niewspółpracującymi, byli bardziej skrupulatni w przestrzeganiu zaleceń lekarskich, dysponowali większą wiedzą na temat swojego leczenia oraz byli bardziej zadowoleni z jego efektów, lepiej funkcjonowali społecznie i byli bardziej aktywni zawodowo, lepiej oceniali siebie i swoje życie pod względem: poczucia sprawstwa, optymizmu, satysfakcji z życia.WnioskiOtrzymane wyniki wskazują, że systematyczna współpraca z lekarzem sprzyja lepszemu funkcjonowaniu pacjentów ze schizofrenią.
Internet Addiction Disorder in a Sample of 402 High School Students
Authors: Taranto Francesco , Goracci Arianna , Bolognesi Simone , Borghini Elisa , Fagiolini Andrea 
Published: April 2015

CelW niniejszej pracy miały na celu ocenę występowania IAD w włoskiej próbie uczniów szkół średnich. Mamy również zbadać związek między fobią społeczną i diagnozy IAD; wreszcie, zbadaliśmy związek między IAD i nadużywania substancji.MetodaBadania przeprowadzono zgodnie z Deklaracją Helsińską. Oceny podawane w tym badaniu składał się z trzech części: 1) gromadzenie informacji o ogólnych i osobistych danych przedmiotów, 2) kwestionariusz Uzależnienie od Internetu zaproponowana przez KO, składa się 9 różnych obszarach; 3) lęk społeczny Spectrum Self-Report (Nieśmiałych -SR) Lifetime kwestionariusz.Wyniki19 z 402 badanych (tj. 4,7% próby) spełnia kryteria diagnostyczne dla IAD, pokazując niewielką przewagę mężczyzn. 10,9% pacjentów spełniało kryteria diagnostyczne dla zaburzenia fobii społecznej Spectrum. Sześć podmiotów IAD (31,8%) były również zdiagnozowano stan spektrum fobii społecznej. W grupie uczniów ze zdiagnozowanym IAD, 4 (21,05%), badani obecnie lub w przeszłości stosowanie leków.WnioskiNasze wyniki sugerują, że istnieje spora populacja młodzieży już pokazano i na ryzyko wystąpienia jakiś problemów w stosunkach z sieci. Zaburzenie lękowe społecznej wydaje się być zarówno czynnikiem ryzyka i często współwystępują zaburzenia Internetu nadużycia. Dalsze badania wraz z wspólnych kryteriów diagnostycznych i narzędzi ułatwi badania nad sposobami leczenia tych szybko rozwijających się i wyłączanie warunków.
Founder or Joiner? The Role of Preferences and Context in Shaping Different Entrepreneurial Interests
Authors: Roach Michael , Sauermann Henry 
Published: April 2015

Entrepreneurial ventures rely not only on founders but also on “joiners”—start-up employees who are attracted to entrepreneurship, but who do not want to be founders themselves. Drawing on both preference and contextual theories of entrepreneurship, we examine how individuals’ interest in being a founder, a joiner, or neither forms prior to the first career transition. We find that although individuals with founder and joiner interests share similar preferences for entrepreneurial job attributes such as autonomy and risk, their preferences for these attributes also differ in significantly meaningful ways. Contextual factors such as norms, role models, and opportunities exhibit very different relationships with founder and joiner interests. Most interestingly, our results suggest that preferences and context interrelate in unique ways to shape different entrepreneurial interests. In particular, an interest in being a founder is most strongly associated with individuals’ preferences for entrepreneurial job attributes, whereas contextual factors do little to shape a founder interest in individuals who lack these preferences. An interest in being a joiner, on the other hand, is associated with both preferences and context, and this relationship is most pronounced for individuals with preferences that predispose them toward entrepreneurship. This study highlights joiners as a distinct type of entrepreneurial actor and demonstrates the importance of considering the interplay between preferences and context in the study of entrepreneurship.This paper was accepted by David Hsu, entrepreneurship and innovation.