bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric analysis of global research trends between gut microbiota and breast cancer: from 2013 to 2023
Authors: Deng Xianguang , Yang Hua , Tian Lingjia , Ling Jie , Ruan Hui , Ge Anqi , Liu Lifang , Fan Hongqiao 
Published: July 2024

BackgroundBreast cancer is the most prevalent cancer globally and is associated with significant mortality. Recent research has provided crucial insights into the role of gut microbiota in the onset and progression of breast cancer, confirming its impact on the disease’s management. Despite numerous studies exploring this relationship, there is a lack of comprehensive bibliometric analyses to outline the field’s current state and emerging trends. This study aims to fill that gap by analyzing key research directions and identifying emerging hotspots.MethodPublications from 2013 to 2023 were retrieved from the Web of Science Core Collection database. The VOSviewer, R language and SCImago Graphica software were utilized to analyze and visualize the volume of publications, countries/regions, institutions, authors, and keywords in this field.ResultsA total of 515 publications were included in this study. The journal Cancers was identified as the most prolific, contributing 21 papers. The United States and China were the leading contributors to this field. The University of Alabama at Birmingham was the most productive institution. Peter Bai published the most papers, while James J. Goedert was the most cited author. Analysis of highly cited literature and keyword clustering confirmed a close relationship between gut microbiota and breast cancer. Keywords such as “metabolomics” and “probiotics” have been prominently highlighted in the keyword analysis, indicating future research hotspots in exploring the interaction between metabolites in the breast cancer microenvironment and gut microbiota. Additionally, these keywords suggest significant interest in the therapeutic potential of probiotics for breast cancer treatment.ConclusionResearch on the relationship between gut microbiota and breast cancer is expanding. Attention should be focused on understanding the mechanisms of their interaction, particularly the metabolite-microbiota-breast cancer crosstalk. These insights have the potential to advance prevention, diagnosis, and treatment strategies for breast cancer. This bibliometric study provides a comprehensive assessment of the current state and future trends of research in this field, offering valuable perspectives for future studies on gut microbiota and breast cancer.
Brain-computer interface on wrist training with or without neurofeedback in subacute stroke: a study protocol for a double-blinded, randomized control pilot trial
Authors: Kim Myeong Sun , Park Hyunju , Kwon Ilho , An Kwang-Ok , Shin Joon-Ho 
Published: July 2024

BackgroundAfter a stroke, damage to the part of the brain that controls movement results in the loss of motor function. Brain-computer interface (BCI)-based stroke rehabilitation involves patients imagining movement without physically moving while the system measures the perceptual-motor rhythm in the motor cortex. Visual feedback through virtual reality and functional electrical stimulation is provided simultaneously. The superiority of real BCI over sham BCI in the subacute phase of stroke remains unclear. Therefore, we aim to compare the effects of real and sham BCI on motor function and brain activity among patients with subacute stroke with weak wrist extensor strength.MethodsThis is a double-blinded randomized controlled trial. Patients with stroke will be categorized into real BCI and sham BCI groups. The BCI task involves wrist extension for 60 min/day, 5 times/week for 4 weeks. Twenty sessions will be conducted. The evaluation will be conducted four times, as follows: before the intervention, 2 weeks after the start of the intervention, immediately after the intervention, and 4 weeks after the intervention. The assessments include a clinical evaluation, electroencephalography, and electromyography using motor-evoked potentials.DiscussionPatients will be categorized into two groups, as follows: those who will be receiving neurofeedback and those who will not receive this feedback during the BCI rehabilitation training. We will examine the importance of motor imaging feedback, and the effect of patients’ continuous participation in the training rather than their being passive.Clinical Trial Registration: KCT0008589.
Summary of the best evidence for nutritional support programs in nasopharyngeal carcinoma patients undergoing radiotherapy
Authors: Fan Xiaomei , Cui Huixia , Liu Shasha 
Published: July 2024

ObjectiveTo evaluate and summarize the best evidence for nutritional support in patients receiving radiotherapy for nasopharyngeal carcinoma and to offer guidance for clinical practice.BackgroundPatients with nasopharyngeal carcinoma undergoing radiotherapy often experience a high prevalence of malnutrition, and there is a lack of compiled guideline recommendations, which complicates the provision of a reference for clinical nursing.MethodsA systematic literature search revealed the best evidence of nutritional support for nasopharyngeal carcinoma patients undergoing radiotherapy. Included in the review were various types of literature, such as clinical guidelines, expert consensus, systematic evaluations, meta-analyses, evidence summaries, and original studies. The evidence was graded according to the Australian Joanna Briggs Institute Centre for Evidence-Based Health Care Evidence Pre-Grading System (2016 version). Data were gathered from a range of sources, including BMJ Best Practice, the Scottish Intercollegiate Guidelines Network, the Cochrane Library, Embase, PubMed, Web of Science, CINAL, CNKI, the WanFang database, SinoMed, the Yi Maitong Guidelines Network, Dingxiangyuan, the Chinese Nutrition Society, the European Society for Clinical Nutrition and Metabolism website, and the American Society for Parenteral and Enteral Nutrition website. The search spanned from January 2013 to 2023.ResultsA comprehensive review identified a total of 3,207 articles, comprising six guidelines, eight expert consensus articles, four systematic evaluations, five randomized controlled trials, two cohort trials, and two observational studies. From these articles, we synthesized 63 pieces of evidence spanning six domains: nutritional risk screening and assessment, nutrient requirements, nutritional support, management of nutritional symptoms, functional exercise, and nutritional monitoring and follow-up.ConclusionA total of lines of evidence supporting nutritional support for nasopharyngeal carcinoma patients receiving radiotherapy were summarized. However, the evidence should be combined with the actual clinical situation, and it should be validated in the future by combining large-sample and multicenter studies to provide a more scientific and beneficial nutritional support program for nasopharyngeal carcinoma patients receiving radiotherapy.
Association between polyphenol subclasses and prostate cancer: a systematic review and meta-analysis of observational studies
Authors: Huang Yiping , Wang Wenyan , Jin Jianxiang 
Published: July 2024

BackgroundThe effect of polyphenol subclasses on prostate cancer (PCA) is controversial. Therefore, the purpose of this study was to investigate the relationship between polyphenol subclasses and PCA incidence.MethodsFrom the establishment of the database to December 2023, a systematic search was conducted on PubMed, Web of Science, Embase, and Cochrane Library to identify relevant observational studies. The adjusted odds ratio (OR) and corresponding 95% confidence interval (95% CI) were used to assess the association.ResultsA total of 38 studies (11 were cohort studies and 27 were case–control studies), composing 824,933 participants, were included in this meta-analysis after excluding irrelevant records. The findings of the study revealed that men who consumed dietary polyphenols had a significantly higher risk of PCA compared to those who never or rarely consumed dietary polyphenols (OR = 1.01, p = 0.023), especially dietary flavonol (OR = 1.05, p = 0.042), flavanol (OR = 1.03, p = 0.026) and anthocyanin (OR = 1.06, p = 0.001). Neither total nor subclasses of dietary polyphenols have an effect on non-localized or high-grade PCA (OR = 1.01, p = 0.518). Dietary isoflavones tended to reduce the incidence of local or low-grade PCA, although there was no statistically significant difference (OR = 1.00, p = 0.081). Regarding serum/plasma polyphenol, total polyphenol (OR = 0.95, p = 0.002), genistein (OR = 0.92, p = 0.029) and enterolactone (OR = 0.92, p = 0.022) can reduce the incidence of PCA. No association was observed between total/subclasses of urinary polyphenols and PCA risk.ConclusionPolyphenols seem to generally increase the risk of PCA in the male population. The effect of polyphenols on PCA is affected by factors such as polyphenol subclasses, their forms (serum/plasma, urinary, dietary), and PCA-related factors (like PCA stage).Systematic review registrationidentifier: CRD42022322699.
Variations in water use strategies of Tamarix ramosissima at coppice dunes along a precipitation gradient in desert regions of northwest China
Authors: Xu Yanqin , Zhao Hui , Zhou Binqian , Dong Zhengwu , Li Guangying , Li Shengyu 
Published: July 2024

IntroductionThe precipitation pattern has changed significantly in arid desert areas, yet it is not clear how the water use strategies of Tamarix ramosissima Ledeb. on coppice dunes along a natural precipitation gradient are affected.MethodsIn this study, the hydrogen and oxygen isotope compositions of xylem water, soil water, precipitation, and groundwater were measured by stable isotope techniques in Huocheng, Mosuowan, and Tazhong. Additionally, the water use strategies of natural precipitation gradient were investigated in conjunction with the MixSIAR model.ResultsThe results indicated that the water sources of T. ramosissima exhibited significant variation from semi-arid to hyper-arid areas. In semi-arid areas, T. ramosissima mainly absorbed shallow, shallow-middle, and middle soil water; however, T. ramosissima shifted its primary water sources to middle and deep soil water in arid areas. In hyper-arid areas, it mainly utilized deep soil water and groundwater. In contrast, the water source contribution rate of T. ramosissima exhibited relative uniformity across each layer in an arid area. Notably, in hyper-arid areas, the proportion of groundwater by T. ramosissima was significantly high, reaching 60.2%. This is due to the relatively shallow groundwater supplementing the deep soil water content in the area. In conclusion, the proportion of shallow soil water decreased by 14.7% for T. ramosissima from semi-arid to hyper-arid areas, illustrating the occurrence of a gradual shift in potential water sources utilized by T. ramosissima from shallow to deep soil water and groundwater.DiscussionTherefore, T. ramosissima on coppice dunes shows flexible water use strategies in relation to precipitation and groundwater, reflecting its strong environmental adaptability. The findings hold significant implications for the conservation of water resources and vegetation restoration in arid areas.
Does exercise adherence during the COVID-19 pandemic contribute to improved subjective well-being? A cross-sectional study
Authors: Chen Yonghuan , Fang Ning , Zhu Yulong , Li Zhenyu , Zhu Qiuhan 
Published: July 2024

IntroductionThis study aims to investigate whether exercise adherence and positive mental character significantly affect subjective well-being among Chinese college students during the COVID-19 pandemic and whether positive mental character plays a mediating role.MethodsThe study employed questionnaires, including the Exercise Adherence Scale, the Positive Mental Character Scale, and the Subjective Well-Being Scale, which were administered to students across seven universities in Henan Province, China. A total of 1,001 participants were analyzed in the final sample. Data were analyzed using SPSS 21.0 for descriptive statistics, independent samples T-test, correlation, and regression analyses. Furthermore, structural equation model with AMOS was conducted to examine the potential mediating effect of positive mental characteristics on the relationship between exercise adherence and subjective well-being.ResultsThe results indicated significant differences in exercise adherence, positive mental character, and subjective well-being between male and female participants, with males scoring higher in all three domains. Among Chinese university students during the COVID-19 pandemic, there was a significant correlation among exercise adherence, positive mental character, and subjective well-being. Exercise adherence was found to have a significant and positive impact on both positive mental character and subjective well-being. Additionally, it was found that positive mental character had a significant positive association with subjective well-being. The mediating role of positive mental character in the relationship between exercise adherence and subjective well-being was partially supported.DiscussionExercise adherence among Chinese college students had a significant positive association on both positive mental character and subjective well-being throughout the COVID-19 pandemic. The exercise adherence can directly or indirectly enhance subjective well-being through its association with positive mental character. Therefore, positive mental and subjective well-being can be enhanced by consistent physical activity even during a pandemic.
Study of genotoxic and cytotoxic effects induced in human fibroblasts by exposure to pulsed and continuous 1.6 GHz radiofrequency
Authors: Massaro Luca , De Sanctis Stefania , Franchini Valeria , Regalbuto Elisa , Alfano Gaetano , Focaccetti Chiara , Benvenuto Monica , Cifaldi Loredana , Sgura Antonella , Berardinelli Francesco , Marinaccio Jessica , Barbato Federica , Rossi Erica , Nardozi Daniela , Masuelli Laura , Bei Roberto , Lista Florigio 
Published: July 2024

BackgroundThe widespread use of radiofrequency (RF) sources, ranging from household appliances to telecommunications devices and military equipment, raises concerns among people and regulatory agencies about the potential health risks of RF exposure. Consequently, several in vitro and in vivo studies have been done to investigate the biological effects, in particular non-thermal, of this non-ionizing radiation. To date, this issue is still being debated due to the controversial results that have been reported. Furthermore, the impact of different RF signal modulations on biological systems remains poorly investigated. The present in vitro study aims to evaluate the cytotoxicity and genotoxicity of continuous or pulsed 1.6 GHz RF in human dermal fibroblasts (HDF).MethodsHDF cultures were exposed to continuous and pulsed 1.6 GHz RF, for 2 h, with Specific Absorption Rate (SAR) of 0.4 W/kg. The potential biological effects of 1.6 GHz RF on HDF were assessed with a multi-methodological approach, analyzing the effects on cell cycle, ultrastructure, protein expression, mitotic spindle, CREST stained micronuclei, chromosome segregation and γ-H2AX/53BP1 foci.Results1.6 GHz RF exposure modified proteins expression and morphology of HDF. Specifically, the expression of different heat-shock proteins (HSP) (i.e., HSP-90, HSP-60, and HSP-25) and phospho-AKT were affected. In addition, both continuous and pulsed RF modified the cytoskeletal organization in HDF and increased the number of lysosomes, while the formation of autophagosomes was observed only after pulsed RF exposure. Mitotic spindle anomalies were also found after exposure. However, no significant effect was observed on cell cycle, chromosome segregation, CREST-stained micronuclei and γ-H2AX/53BP1 foci.ConclusionThe results of the present study show the absence of genotoxic damage in 1.6 GHz RF exposed HDF and, although mitotic spindle alterations were observed, they did not have an aneugenic effect. On the other hand, changes in some proteins expression and cell ultrastructure in exposed HDF suggest that RF can potentially induce cell alterations at the morphological and molecular levels.
Facilitating regular Physical Education for students with disability—PE teachers' views
Authors: Bertills Karin , Björk Maria 
Published: July 2024

IntroductionThe objective of this study is to describe how Physical Education (PE) teachers work to facilitate participation for students with disability in compulsory, mainstream inclusive, secondary school. Inclusive school-based Physical Education (PE) is an important context for students to share the benefits of physical activities with peers, especially for students with disability whose opportunities for participation in extracurricular physical activity are limited.MethodsTwo focus group interviews were performed with eight experienced PE teachers who teach students with disability in regular PE. Qualitative content analysis was used to analyze the interviews. Two themes emerged, the importance of having a structured and welcoming environment and the need to adapt the PE environment.ResultsStudent mastery experiences is emphasized and achieved by teaching approaches encouraging peer collaboration before physical performance and competition. Key aspects to participation for students with disabilities are inclusive mindsets, proper preparation, and adaptations. Special arrangements when participation in-class is not possible require regular and close teacher-student communication and, when needed, additional support.DiscussionExperiences of participation are important matters for further advancement of equality and social inclusion for students with disability. Schools need to develop support structures to provide students with disability with “real-life” experiences that optimize participation.
High-throughput rapid amplicon sequencing for multilocus sequence typing of Mycoplasma ovipneumoniae from archived clinical DNA samples
Authors: Framst Isaac , Wolking Rebecca M. , Schonfeld Justin , Ricker Nicole , Beeler-Marfisi Janet , Chalmers Gabhan , Kamath Pauline L. , Maboni Grazieli 
Published: July 2024

IntroductionSpillover events of Mycoplasma ovipneumoniae have devastating effects on the wild sheep populations. Multilocus sequence typing (MLST) is used to monitor spillover events and the spread of M. ovipneumoniae between the sheep populations. Most studies involving the typing of M. ovipneumoniae have used Sanger sequencing. However, this technology is time-consuming, expensive, and is not well suited to efficient batch sample processing.MethodsOur study aimed to develop and validate an MLST workflow for typing of M. ovipneumoniae using Nanopore Rapid Barcoding sequencing and multiplex polymerase chain reaction (PCR). We compare the workflow with Nanopore Native Barcoding library preparation and Illumina MiSeq amplicon protocols to determine the most accurate and cost-effective method for sequencing multiplex amplicons. A multiplex PCR was optimized for four housekeeping genes of M. ovipneumoniae using archived DNA samples (N = 68) from nasal swabs.ResultsSequences recovered from Nanopore Rapid Barcoding correctly identified all MLST types with the shortest total workflow time and lowest cost per sample when compared with Nanopore Native Barcoding and Illumina MiSeq methods.DiscussionOur proposed workflow is a convenient and effective method for strain typing of M. ovipneumoniae and can be applied to other bacterial MLST schemes. The workflow is suitable for diagnostic settings, where reduced hands-on time, cost, and multiplexing capabilities are important.
Contribuciones de la gestión de procesos y ventajas competitivas en las asociaciones agrícolas
Authors: Guanotuña Guanoluisa Yomaira Elizabeth , Ortiz Pallo Jennifer Yajaira , Pazmiño Cano Gloria Evelina 
Published: July 2024

Alinear procesos y ventajas competitivas mejora el desempeño de asociaciones agrícolas, pues optimiza eficiencia, costos y calidad, clave para adaptación e innovación. En este sentido, el objetivo del presente estudio fue determinar la relación entre las dimensiones gestión de procesos y ventajas competitivas de las asociaciones agrícolas del Cantón La Maná. La investigación fue desarrollada con un enfoque cuantitativo, de corte transversal y con un alcance correlacional. Para la cual se seleccionó una muestra de 140 socios pertenecientes a cuatro asociaciones agrícolas seleccionadas del cantón La Maná a los cuales se les aplicó el instrumento elaborado. Las relaciones más significativas se dieron entre: cambio y economía (0.834); cambio y calidad (0.793); capacidad y eficiencia (0.772); eficiencia y capacidad (0.705), y eficiencia y economía (0.678), sugiriendo que optimizar recursos y minimizar desperdicios aumenta competitividad y mejora producción y calidad. Se concluye que las ventajas competitivas basadas en cambio, que contemplan adaptación e innovación constante, presentan mayor impacto, pues las organizaciones con apertura a nuevas tecnologías, fluctuaciones del mercado y demandas de consumidores muestran mejor desempeño, permitiéndoles mantenerse competitivas, acceder a nuevos mercados y oportunidades, impulsando su crecimiento y sostenibilidad a largo plazo.
KEBIJAKAN PEMERINTAH DAERAH DALAM MITIGASI BENCANA BERKAITAN DENGAN PENATAAN RUANG PASCA GEMPA BUMI
Authors: Megawati Leny 
Published: July 2024

ABSTRAKKabupaten Cianjur, dengan sejarah panjangnya terkait kerentanan terhadap bencana alam, khususnya gempa bumi, mengalami peristiwa signifikan pada Senin, 21 November 2022. Bencana tersebut menambah daftar panjang peristiwa alam yang mengguncang wilayah ini, menyebabkan kerugian materi dan korban jiwa yang besar. Kondisi ini mendorong perlunya penanganan yang lebih efektif dalam penataan ruang dan kebijakan mitigasi bencana yang berkelanjutan. Penelitian ini bertujuan untuk mengevaluasi kebijakan pemerintah daerah terkait mitigasi bencana dalam penataan ruang di Kabupaten Cianjur. Fokus utama meliputi proses penentuan tata ruang wilayah, peran politik hukum dalam mitigasi bencana, dan implementasi kebijakan oleh pemerintah daerah. Melalui metode studi literatur dan analisis kebijakan, hasil penelitian menyoroti pentingnya integrasi politik hukum yang berkelanjutan dalam tata ruang pasca bencana. Peran aktif pemerintah, partisipasi masyarakat, dan sinergi antara kebijakan mitigasi bencana serta tata ruang diidentifikasi sebagai krusial dalam membangun ketahanan wilayah terhadap bencana. Peningkatan kesadaran akan politik hukum mitigasi bencana menjadi kunci untuk mencapai tata ruang yang berkelanjutan dan adaptif pasca bencana gempa bumi di Kabupaten Cianjur. ABSTRACTCianjur Regency, with its long history of vulnerability to natural disasters, especially earthquakes, experienced a significant event on Monday, November 21 2022. This disaster added to the long list of natural events that rocked this region, causing material losses and large casualties. This condition encourages the need for more effective management in spatial planning and sustainable disaster mitigation policies. This research aims to evaluate local government policies regarding disaster mitigation in spatial planning in Cianjur Regency. The main focus includes the process of determining regional spatial planning, the role of legal politics in disaster mitigation, and policy implementation by local governments. Through literature study and policy analysis methods, the research results highlight the importance of sustainable integration of legal politics in post-disaster spatial planning. The active role of government, community participation, and synergy between disaster mitigation policies and spatial planning are identified as crucial in building regional resilience to disasters. Increasing awareness of the legal politics of disaster mitigation is the key to achieving sustainable and adaptive spatial planning after the earthquake disaster in Cianjur Regency.