bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathogenicity of genotype 2.1 classical swine fever virus isolated from Japan in 2019 in pigs
Authors: Yamashita Maiko , Iwamoto Shoko , Ochiai Mariko , Yamamoto Atsushi , Sudo Kasumi , Narushima Rie , Nagasaka Takao , Saito Akito , Oba Mami , Omatsu Tsutomu , Mizutani Tetsuya , Yamamoto Kinya 
Published: July 2024

AbstractClassical swine fever (CSF) re‐emerged in Japan in 2018 for the first time in 26 years. The disease has been known to be caused by a moderately pathogenic virus, rather than the highly pathogenic virus that had occurred in the past. However, the underlying pathophysiology remains unknown. This study conducted an experimental challenge on specific pathogen‐free (SPF) pigs in a naïve state for 2, 4, and 6 weeks and confirmed the disease state during each period by clinical observation, virus detection, and pathological necropsy. We revealed the pathological changes and distribution of pathogens and virus‐specific antibodies at each period after virus challenge. These results were comprehensively analyzed and approximately 70% of the pigs recovered, especially at 4‐ and 6‐week post‐virus challenge. This study provides useful information for future countermeasures against CSF by clarifying the pathogenicity outcomes in unvaccinated pigs with moderately pathogenic genotype 2.1 virus.
Does fiscal decentralization improve people's access to health and education services in Cameroon?
Authors: Fouopi Djiogap Constant , Manga Justin Romuald Amougou , Onana Simon Pierre , Bitoto Fabrice Ewolo 
Published: July 2024

AbstractWe study the effects of fiscal decentralization on people's access to health and education services in Cameroon. It is generally believed that fiscal decentralization is an essential way to improve people's access to social services such as education and health. After reviewing the literature, we employed the Driscoll and Kraay estimate in a sample of 45 rural and urban municipalities for the period 2010–2020 to find our results. The results show that fiscal decentralization has a positive effect on the number of classrooms per pupil and the number of desks per pupil. At the same time, it negatively affects public hospitals per capita and the state of public hospitals. To improve people's access to education and health services in Cameroon, it is necessary to encourage the transfer of powers to municipalities. There is a need to control the actions of local officials to avoid mismanagement of resources that will not benefit the population. Also, the responsibility for selecting communal projects financed via the public investment budget within the framework of decentralization should be exclusively that of municipal executives, and not that of the central government.
A third indeterminacy of labour power: Worker health investment and the indeterminacy of labour health
Authors: Harvey Geraint , Wallace James 
Published: July 2024

AbstractThis article identifies the health of the worker as a third source of labour power indeterminacy to be added to the indeterminacy of labour effort and the indeterminacy of labour mobility. The paper clearly differentiates worker health from effort as a distinct source of labour power indeterminacy—something that cannot be guaranteed and that varies for an individual over time. It considers the relationship between worker health as a new source of indeterminacy and the two extant sources of labour power indeterminacy, focussing on the way in which health moderates the relationship between effort and output. The paper also considers the way in which worker health investment moderates the indeterminacy of labour effort and labour mobility, independently of its impact on the health of the worker. The paper documents the potential value of worker health investment to the organisation and also considers the boundary conditions for investment in worker health.
Evolutionary biology of social expertise
Authors: Dukas Reuven , Bailey Nathan W. 
Published: July 2024

ABSTRACTThere is increasing evidence that competent handling of social interactions among conspecifics has positive effects on individual fitness. While individual variation in social competence has been appreciated, the role of long‐term experience in the acquisition of superior social skills has received less attention. With the goal of promoting further research, we integrate knowledge across disciplines to assess social expertise, defined as the characteristics, skills and knowledge allowing individuals with extensive social experience to perform significantly better than novices on a given social task. We focus on three categories of social behaviour. First, animals can gain from adjusting social behaviour towards individually recognised conspecifics that they interact with on a regular basis. For example, there is evidence that some territorial animals individually recognise their neighbours and modify their social interactions based on experience with each neighbour. Similarly, individuals in group‐living species learn to associate with specific group members based on their expected benefits from such social connections. Individuals have also been found to devote considerable time and effort to learning about the spatial location and timing of sexual receptivity of opposite‐sex neighbours to optimise reproduction. Second, signallers can enhance their signals, and receivers can refine their response to signals with experience. In many birds and insects, individuals can produce more consistent signals with experience, and females across a wide taxonomic range can adaptively adjust mating preferences after perceiving distinct male signals. Third, in many species, individuals that succeed in reproducing encounter the novel, complex task of caring for vulnerable offspring. Evidence from a few species of mammals indicates that mothers improve in providing for and protecting their young over successive broods. Finally, for social expertise to evolve, heritable variation in social expertise has to be positively associated with fitness. Heritable variation has been shown in traits contributing to social expertise including social attention, empathy, individual recognition and maternal care. There are currently limited data associating social expertise with fitness, most likely owing to sparse research effort. Exceptions include maternal care, signal refinement, and familiarity with neighbours and group members. Overall, there is evidence that individuals in many species keep refining their social skills with experience throughout life. Hence we propose promising lines of research that can quantify more thoroughly the development of social expertise and its effects on fitness.
Recent trends in firm‐level total factor productivity in the UK: new measures, new puzzles
Authors: Coyle Diane , McHale John , Bournakis Ioannis , Mei Jen‐Chung 
Published: July 2024

AbstractUnderstanding the poor productivity performance of the UK economy since the financial crisis is complicated by the well‐known challenges in estimating total factor productivity (TFP) using only revenue data. We develop a structural framework to infer quality‐adjusted TFP from an estimated firm‐level revenue function. We use microdata for two sectors previously identified as being significant contributors to the UK's productivity growth slowdown—manufacturing and ICT—from 2008 to 2019. The revenue function is estimated using the Blundell–Bond System GMM estimator. We also use an alternative cost‐shares approach to identifying and measuring TFP. For both methods, we find an overall fall in TFP levels in manufacturing and a rise in ICT. We find a striking decline of between 13% and 18% in the level of within‐firm manufacturing TFP, and of between 11% and 16% in ICT, although with reallocation effects differing between the two sectors. The finding of declining within‐firm TFP is robust, although the magnitude varies between methods. We discuss a possible explanation for this extended UK productivity puzzle based on the relative underperformance of UK firms in international markets.
Interobserver agreement during clinical magnetic resonance imaging of the equine foot
Authors: Byrne Christian A. , Voute Lance C. , Marshall John F. 
Published: July 2024

AbstractBackgroundAgreement between experienced observers for assessment of pathology and assessment confidence are poorly documented for magnetic resonance imaging (MRI) of the equine foot.ObjectivesTo report interobserver agreement for pathology assessment and observer confidence for key anatomical structures of the equine foot during MRI.Study designExploratory clinical study.MethodsTen experienced observers (diploma or associate level) assessed 15 equine foot MRI studies acquired from clinical databases of 3 MRI systems. Observers graded pathology in seven key anatomical structures (Grade 1: no pathology, Grade 2: mild pathology, Grade 3: moderate pathology, Grade 4: severe pathology) and provided a grade for their confidence for each pathology assessment (Grade 1: high confidence, Grade 2: moderate confidence, Grade 3: limited confidence, Grade 4: no confidence). Interobserver agreement for the presence/absence of pathology and agreement for individual grades of pathology were assessed with Fleiss' kappa (k). Overall interobserver agreement for pathology was determined using Fleiss' kappa and Kendall's coefficient of concordance (KCC). The distribution of grading was also visualised with bubble charts.ResultsInterobserver agreement for the presence/absence of pathology of individual anatomical structures was poor‐to‐fair, except for the navicular bone which had moderate agreement (k = 0.52). Relative agreement for pathology grading (accounting for the ranking of grades) ranged from KCC = 0.19 for the distal interphalangeal joint to KCC = 0.70 for the navicular bone. Agreement was generally greatest at the extremes of pathology. Observer confidence in pathology assessment was generally moderate to high.Main limitationsDistribution of pathology varied between anatomical structures due to random selection of clinical MRI studies. Observers had most experience with low‐field MRI.ConclusionsEven with experienced observers, there can be notable variation in the perceived severity of foot pathology on MRI for individual cases, which could be important in a clinical context.
Porous Yb2Si2O7 coating: A new‐type high‐temperature‐resistant abradable seal coating
Authors: Xu Mengjun , Luo Zhixin , Hou Xiaoyang , Wang Haoyu , Wu Zhen , Wang Lu , Wang Jingyang 
Published: July 2024

AbstractTraditional abradable seal coatings (ASCs) face huge challenges for the requirements of next‐generation aero engines due to high inlet temperature (>1300°C) and non‐matched coefficients of thermal expansion for SiC based composites. Herein, a novel Yb2Si2O7 seal coating was developed to meet the demands of high‐temperature resistance and match the coefficient of thermal expansion with SiC. The prepared Yb2Si2O7 seal coating has excellent properties, including high porosity of 35.5%–23.3%, moderate hardness of 77.9–82.5 HR15Y, and high bond strength of 7.8–9.0 MPa. Adjusting spray current could effectively control the thickness, porosity, and hardness of the coating. More importantly, the coating also has good erosion resistance. Our results show that the fabricated porous Yb2Si2O7 coating would have promising applications in the field of high‐temperature ASCs.
Transcriptomic and proteomic elucidation of Z chromosome dosage compensation in Helicoverpa armigera
Authors: Deng Zhongyuan , Zhang Yakun , Xie Xingcheng , Li Huihui , Guo Han , Ni Xinzhi , Li Xianchun 
Published: July 2024

AbstractTranscriptomic data have been used to study sex chromosome dosage compensation (SCDC) in approximately 10 Lepidoptera ZW species, yielding a consensus compensation pattern of Z It remains unclear whether this compensation pattern holds when examining more Lepidoptera ZW species and/or using proteomic data to analyse SCDC. Here we combined transcriptomic and proteomic data as well as transcriptional level of six individual Z genes to reveal the SCDC pattern in Helicoverpa armigera, a polyphagous lepidopteran pest of economic importance. Transcriptomic analysis showed that the Z chromosome expression of H. armigera was balanced between male and female but substantially reduced relative to autosome expression, exhibiting an SCDC pattern of Z . When using H. amigera midgut proteomic data, the SCDC pattern of this species changed from Z at transcriptomic level to Z = ZZ = AA at the proteomic level. RT‐qPCR analysis of transcript abundance of six Z genes found that compensation for each Z gene could vary from no compensation to overcompensation, depending on the individual genes and tissues tested. These results demonstrate for the first time the existence of a translational compensation mechanism, which is operating in addition to a translational mechanism, such as has been reported in other lepidopteran species. And the transcriptional compensation mechanism functions to accomplish Z chromosome dosage balance between the sexes (M = F on the Z chromosome), whereas the translation compensation mechanism operates to achieve dosage compensation between Z chromosome and autosome (Z = AA).
Medical oncologist perceptions and willingness to participate in voluntary assisted dying in South Australia
Authors: Forgione Michelle O. , Smith Annabel , Hocking Christopher M. 
Published: July 2024

AbstractThis study surveyed South Australian medical oncologists to capture their perceptions, willingness to participate and perceived barriers and motivations to participation in voluntary assisted dying (VAD) activities. Approximately 70% of surveyed medical oncologists reported familiarity with VAD legislation. Less than half of physicians (39.1%) reported willingness to participate in any VAD activities, and the rate of conscientious objection was 22%. The top barriers to participation were lack of time and uncertainty given no prior experience. These results demonstrate both a low rate of conscientious objection and a low rate of willingness to participate at the point of VAD implementation in South Australia, and identify barriers to participation that are largely logistical.
Analysis of Carbon Flux Characteristics in Saline–Alkali Soil Under Global Warming
Authors: Haonan Qiu , Shihong Yang , Guangmei Wang , Xiaoling Liu , Jie Zhang , Yi Xu , Shide Dong , Hanwen Liu , Zewei Jiang 
Published: July 2024

ABSTRACTThe carbon cycle of saline–alkali ecosystems will be affected to some extent in the context of future global warming. Therefore, we investigated the net ecosystem exchange (NEE) of three typical crops (wheat, maize and soybean) in the saline–alkaline land of the Yellow River Delta. To further investigate CO2 fluxes, NEE was decomposed into gross primary productivity (GPP) and ecosystem respiration (Re). In terms of seasonal variation, wheat and soybean were carbon sources in the early and late growth periods, and carbon sinks in the rest of the period, whereas maize was a carbon sink in the majority of the period, and maize had good carbon sink potential. The cumulative NEE during the growth periods for wheat, maize, and soybean were 414.86, 258.24 and 228.92 g cm−2, respectively, and the daily variation showed that the peak NEE values for the three crops preceded the peak values of both GPP and ecosystem respiration, occurring approximately at 12:00 a.m. In the correlation analysis, NEE and GPP of the three crops were well correlated with photosynthetic photon flux density and net radiation, whereas Re was significantly correlated with air temperature. Through a comparative analysis of CO2 fluxes within various agricultural ecosystems, our findings indicated that wheat demonstrated moderate carbon sequestration capabilities, whereas maize and soybean exhibited strong carbon sink characteristics. Notably, saline–alkali crops exhibited lower Re, whereas GPP levels remained at a moderate range. Therefore, under the global warming trend, the respiration of saline crops and soils will be affected and may change the original carbon sink into a carbon source. Hence, implementing suitable measures targeting saline–alkali areas, such as the establishment of an effective crop rotation system and the enhance saline–alkali land conditions, can reduce emissions of greenhouse gases, thus reducing the pressure of global warming and maintaining a stable carbon cycle in saline–alkali land.
Multigenerational Effects of Elevated CO2 and N Supply on Leaf Gas Exchange Traits in Wheat Plants
Authors: Wang Xizi , Rosenqvist Eva , Zong Yuzheng , Li Xiangnan , Liu Fulai 
Published: July 2024

ABSTRACTThe responses of leaf gas exchange of wheat (Triticum aestivum L.) to elevated atmospheric CO2 concentration (e[CO2]) were often investigated within a single generation, while the long‐term acclimation of photosynthesis to growth in e[CO2] over multiple generations has not been systematically studied. Here, five wheat cultivars were grown under either ambient (a[CO2], 400 ppm) or elevated (e[CO2], 800 ppm) CO2 concentration for three consecutive generations (G1 to G3) with two N‐fertilisation levels (1N–1 g N pot−1 and 2N–2 g N pot−1) in climate‐controlled greenhouses. Leaf gas exchange was determined in each generation of plants under different treatments. It was found that at both N levels, e[CO2] stimulated photosynthetic rate while reducing stomatal conductance, transpiration rate and leaf N concentration, resulting in an enhanced water use efficiency and photosynthetic N use efficiency. The N level modulated the intergenerational responses of photosynthetic capacity to e[CO2]; under low N supply, the maximum carboxylation rate (Vcmax), the maximum electron transport rate (Jmax) and the rate of triose phosphate utilisation (TPU) were significantly downregulated by e[CO2] from the first to the second generation, but recovered in the third generation; whereas at high N levels, photosynthetic acclimation was diminished with the progress of generations, with Vcmax, Jmax and TPU increased under e[CO2] in the third generation. These results suggest that intergenerational adaptation could alleviate the e[CO2]‐induced reduction of the photosynthetic capacity, but plants with different N status responded differently to adapt to the long‐term exposure to e[CO2]. Among the five cultivars, 325Jimai showed a better photosynthetic performance under e[CO2] over the three generations, while 02‐1Shiluan appeared to be more inhibited by CO2 elevation in the long term conditions. These findings provide new insights for breeding strategies in the future CO2‐enriched environments.
A sneak peek into chronic glucose exposure and insulin secretion impairment through translatome
Authors: Helena Grace Aprilia , Kume Shoen 
Published: July 2024

Diabetes is an epidemic caused by a multitude of factors. Despite the studies attempting to unravel its mechanism, there is still more to discover about glucose–insulin dynamics. In a recent issue of the Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β‐cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β‐cells.Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β‐cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β‐cells. Their multiomics approach might provide a deeper understanding of high glucose and translational regulation of genes involved in β‐cell insulin impairment caused by prolonged high‐glucose exposure.
Presenilin deficiency enhances tau phosphorylation and its secretion
Authors: Sun Yang , Islam Sadequl , Gao Yuan , Nakamura Tomohisa , Tomita Taisuke , Michikawa Makoto , Zou Kun 
Published: July 2024

AbstractAlzheimer's disease (AD) is characterized by the accumulation of abnormally folded amyloid β‐protein (Aβ) in the brain parenchyma and phosphorylated tau in neurons. Presenilin (PS, PSEN) 1 and PS2 are essential components of γ‐secretase, which is responsible for the cleavage of amyloid precursor protein (APP) to generate Aβ. PSEN mutations are associated with tau aggregation in frontotemporal dementia, regardless of the presence or absence of Aβ pathology. However, the mechanism by which PS regulates tau aggregation is still unknown. Here, we found that tau phosphorylation and secretion were significantly increased in PS double–knock‐out (PS1/2−/−) fibroblasts compared with wild‐type fibroblasts. Tau‐positive vesicles in the cytoplasm were significantly increased in PS1/2−/− fibroblasts. Active GSK‐3β was increased in PS1/2−/− fibroblasts, and inhibiting GSK3β activity in PS1/2−/− fibroblasts resulted in decreased tau phosphorylation and secretion. Transfection of WT human PS1 and PS2 reduced the secretion of phosphorylated tau and active GSK‐3β in PS1/2−/− fibroblasts. However, PS1D257A without γ‐secretase activity did not decrease the secretion of phosphorylated tau. Furthermore, nicastrin deficiency also increased tau phosphorylation and secretion. These results suggest that deficient PS complex maturation may increase tau phosphorylation and secretion. Thus, our studies discover a new pathway by which PS regulates tau phosphorylation/secretion and pathology independent of Aβ and suggest that PS serves as a potential therapeutic target for treating neurodegenerative diseases involving tau aggregation.image
Revisiting class: A feminist political analysis of the Indian Time Use Survey
Authors: Naidu Sirisha , Rao Smriti 
Published: July 2024

AbstractThe literature on agrarian change in India has largely employed class categories based upon data on land, assets and occupational status, which collapse women's class relations into those of (mostly male) households heads. In this paper, we interrogate this understanding of class building on the work of Carmen Diana Deere. Employing the first ever national time use survey conducted in India in 2019, we interrogate class as a labour process that intersects with caste and gender. Our analysis of the data using a Marxist‐feminist framework suggests the following. First, there exist intra‐household gendered differences in class locations. This calls to question theoretical frameworks that assign a cohesive class location to all household members that underlie data collection in India and elsewhere. Second, individuals participate in multiple labour processes depending on their caste and gender. Hence, they may be subsumed to capital in varied and sometimes contradictory ways. Finally, we find that both men and women engage in reproductive labour in addition to other forms of labour, which varies by caste categories. This finding further underscores and supports previous research on the importance of an expanded conception of work that includes reproductive labour. In sum, we argue for a more complex understanding of class in India, one that incorporates its caste and gender dimensions.