bluuebunny/crossref_metadata_2025_split huggingface dataset:
USE SOCIAL MEDIA WISELY IN ACCORDANCE WITH APPLICABLE PROVISIONS
Authors: Umar Santoso Budi Nursal , Rahmat Doris 
Published: July 2024

Social media has become an integral part of everyday life, opening up unprecedented opportunities for communication, collaboration and information exchange. However, with the freedom offered by these platforms also comes the great responsibility to use them wisely and in accordance with applicableregulations. This research aims to explore wise practices in the use of social media and their impact on individuals and society. Through a qualitative approach, data was collected through in-depth interviews and observations of various social media users. The research results show that awareness of privacy, diversity ofopinions, control of posted information, and openness to other people's perspectives are important factors in using social media wisely. Apart from that, this researchalso identifies the challenges and obstacles faced in efforts to make social media a positive communication tool. These findings provide valuable insights forindividuals, institutions, and regulators to develop policies and practices that promote responsible and ethical use of social media. . From the research results, itappears that social media users have varying levels of awareness of the terms of use, but compliance with these rules can vary depending on factors such aspeer pressure, the complexity of the rules, and the influence of the social and cultural environment. Challenges in practicing wise use of social media are alsoapparent, ranging from the pressure to maintain a perfect image to the difficulty in distinguishing between valid information and hoaxes. In addition, the positive impacts of social media, such as social connectivity and access to information, are also accompanied by negative risks, including the spread of hoaxes and mental stress. The influence of the social and cultural environment on social media usage practices reinforces the importance of taking into account an individual's social and cultural context in developing appropriate approaches to managing risks and maximizing the benefits of social media. In this context,awareness of the positive and negative impacts of social media is key to helping individuals and society develop more responsible and ethical practices in the use of these platforms. A holistic approach is needed that combines education, social support, and supportive policies to create a healthy and productive onlineenvironment for all users
Kinerja Karyawan Divisi Sales Di PT. X Ditinjau Dari Motivasi Kerja
Authors: Cahyadi Andi , Matius Wahyu Bannon Tri Nugroho  
Published: July 2024

Penelitian ini bertujuan untuk mencari tahu keterkaitan antara motivasi kerja dengan kinerja karyawan pada divisi sales di PT. X Madiun. metode yang digunakan di dalam penelitian ini menggunakan metode kuantitatif dengan analisis uji hubungan. Skala kinerja dan skala motivasi kerja merupakan alat pengumpul data yang digunakan dalam penelitian ini. Responden yang terlibat di dalam penelitian ini sejumlah 40 karyawan, yang memiliki karakteristik yaitu karyawan yang bekerja di PT.X Madiun, bagian sales dan mempunyai masa kerja di atas satu tahun. Di dalam penelitian ini peneliti menggunakan total sampling sebagai teknik pengambilan sampel, dikarenakan responden kurang 100. Pearson product moment digunakan di dalam penelitian ini untuk menganalisis seberapa kuat hubungan antara kedua variabel tersebut. Hasil penelitian yang diperoleh yaitu koefisien sebesar r = 0.780 dengan p = 0.000 (p < 0.05) dengan arah korelasi positif, artinya terdapat hubungan yang signifikan antara motivasi kerja dengan kinerja karyawan di divisi sales pada PT X di Madiun, semakin tinggi motivasi kerja yang dimiliki oleh karyawan divisi sales PT X, maka akan semakin tinggi pula kinerjanya. Mengacu pada hasil penelitian, maka bisa diambil sebuah kesimpulan bahwa agar karyawan divisi sales pada PT X memiliki kinerja yang baik, maka yang perlu dilakukan adalah dengan menumbuhkan motivasi kerjanya.
Human Skin Microbiota – Essentials for Beauty Studio Professionals
Authors: Gajdka Weronika , Rakoczy Rafał , Augustyniak Adrian 
Published: July 2024

Abstract
Skin, the largest organ in the human body, presents the largest possible area for colonization by microorganisms. The aspects of the interaction between microbiota and the host cannot be omitted during procedures in a beauty studio. Professional cosmetologists should consider their work’s impact on skin biodiversity and know the probable consequences. This review reviewed the current state of the art on skin microbiota with a focus on the connection between body area, microbiological biodiversity and the outcome of cooperation between the host and microorganisms. The role of the skin microbiota in maintaining the host’s homeostasis was also summarized.
Gonococci – Pathogens of Growing Importance. Part 2. Virulence Factors, Antimicrobial Resistance and Vaccine Development
Authors: Białecka Joanna , Rak Katarzyna , Kiecka Aneta 
Published: July 2024

Abstract

Neisseria gonorrhoeae (gonococcus) is a human pathogen, the aetiological agent of gonorrhoea, which is the second most common bacterial sexually transmitted disease (STD) in the world. The structure of N. gonorrhoeae cell wall is typical of Gram-negative bacteria, poses variable antigens porin B (PorB), and opacity-associated proteins (Opa proteins), lipooligosaccharide (LOS) and type IV pili (TFP) playing an essential role in pathogenesis. In addition to adhesins, gonococcus presents other virulence factors such as reducing modifiable protein (Rmp), iron transporters, membrane pumps, and IgA peptidase. The pathogen produces outer membrane vesicles (OMVs), releases peptidoglycan (PG) fragments and is well adapted to develop infection in diverse niches of the female and male reproductive tracts. The characteristic genotypic trait of N. gonorrhoeae is the state of natural competence, which allows DNA uptake from the environment. The antigenic and phase variability is essential to gonococcal defence against the human immune system. Because of the increasing antimicrobial resistance (AMR) of N. gonorrhoeae and the high incidence rate of gonococcal infections, developing an antigonococcal vaccine has become an urgent need. Vaccine development difficulties are mainly due to the gonococcal ability of immune evasion, the lack of an animal model, and the limited understanding of protective immune response mechanisms.
Co-infection with Mycobacterium tuberculosis and Mycobacterium avium in an HIV-positive patient – Case Report
Authors: Roman Aura-Alisia , Tripon Ioana , Tudor Bianca 
Published: July 2024

Abstract

Introduction: The association between Mycobacterium tuberculosis and the Human Immunodeficiency Virus can accelerate the deterioration of immunological functions. The risks are even more accentuated in the situation of a Non-tuberculous Mycobacterium and Mycobacterium tuberculosis co-infection.

Case presentation: We present the case of a 59-year-old male patient, who was admitted at the hospital with non-specific symptoms. Further investigations reveal a remarkable particularity about the case: The infection with Mycobacterium tuberculosis was urogenital, whereas the one with Non-tuberculous mycobacteria was pulmonary.

Conclusion: Both Mycobacterium tuberculosis and Non-tuberculous strains can exist within the same infection, posing great difficulties for diagnosis, as well as the treatment scheme.
Effect of carbamazepine-beta-cyclodextrin inclusion complex on seizure-like events in an in vitro model of temporal lobe epilepsy
Authors: Kiss Rita-Judit , Csüdör Ágnes , Sárosi Máté , Nagy Zsolt András , Szentes Ádám , Gáll Zsolt , Szilágyi Tibor , Orbán-Kis Károly 
Published: July 2024

Abstract

Objective: Pharmacoresistant epilepsy represents a significant global health challenge, necessitating novel therapeutic approaches. Despite advances in antiseizure medications, many patients remain treatment-resistant partially due to complex pharmacokinetic issues. Beta-cyclodextrin, known for enhancing drug solubility and stability, offers potential solutions by forming inclusion complexes, thereby improving anti-seizure medication’s efficacy. This study aimed to investigate the effect of beta-cyclodextrin and beta-cyclodextrin-complexed carbamazepine on epileptiform activities, using an in vitro model of temporal lobe epilepsy.

Methods: Seizure-like neuronal activity was induced using the low-magnesium model. Local field potentials were recorded from transverse rat hippocampal slices immersed in epileptogenic artificial cerebrospinal fluid, followed by the administration of either beta-cyclodextrin or carbamazepine, the latter in 100 micromolar concentration.

Results: Beta cyclodextrin, applied alone, significantly reduced the duration of interictal and ictal phases while increasing the frequency of seizure-like events. Carbamazepine exhibited an important anticonvulsant effect, significantly reducing ictal and postictal phase durations. However, the frequency of seizure-like events was increased. Notably, in some of the slices, carbamazepine completely suppressed epileptiform activity.

Conclusions: Beta cyclodextrin had an effect on its own; it shortened seizure durations and increased their frequency. Carbamazepine in complexed form, as used in our study, exhibited anticonvulsant efficacy, emphasizing the feasibility of solubility enhancement by this method. This study provides insights into potential therapeutic strategies for pharmacoresistant temporal lobe epilepsy, improving the pharmacological properties of the drugs. As cyclodextrins emerge as promising excipients for antiepileptic drugs with poor solubility, more effort is needed in order to elucidate the underlying mechanisms of their effects.
Beneficial effects of Anemone palmata extracts on male rabbit fertility and reproduction
Authors: Meziani Asma , Hafid Hinda , Allaoua Noua , Boulahbel Souad , Bentayeb Yasmina , Moumen Yasmina , Siouani Amina , Gherraf Noureddine 
Published: July 2024

Abstract

Objective: The current study is intended to offer an insight on positive benefits of the herb Anemone palmate belonging to Ranunculaceae family, as an enhancing agent of male rabbit’s fertility.

Methods: Twelve male rabbits, in the growth stage, were divided randomly into four equal groups: one serving as the control and three subjected to different treatments. Anemone palmata extracts (50, 100, and 200 mg/kg) were administered orally to the groups. Blood samples were collected to measure the serum levels of testosterone four weeks later. The weight of the testis and epididymis, sperm count, and sperm motility were determined histologically.

Results: The findings revealed a significant increase in the relative weights of the reproductive organs (testis and epididymis) and plasma testosterone levels in the groups that received the 100 and 200 mg/kg doses. Moreover a notable enhancement in the spermatozoa biology, including concentration, motility, and speed, was observed in the groups treated with 100 and 200 mg/kg doses compared to the control and the group treated with 50mg/kg. The histological study revealed some changes in the spermatogenesis and the structure of the organs, involving the presence of the spermatid phase. A significant increase in the thickness of seminiferous walls, a decrease in the interstitial space, and a reduction in the lumen and intra-tubular spaces were observed as well.

Conclusions: it is well indicated that Anemone palmata could improve fertility factors, and exhibit good effects on gonad and sperm parameters in rabbits.
Ex vivo permeability study and in vitro solubility characterization of oral Canagliflozin self-nanomicellizing solid dispersion using Soluplus® as a nanocarrier
Authors: Jassem Nizar Awish , Alhammid Shaimaa Nazar Abd 
Published: July 2024

Abstract

Background and objective: Self-nanomicellizing solid dispersion SNMSD is a new formulation that combines solid dispersion and nanomicelle strategies; the strategy involves utilizing a suitable carrier that self-assembles into nanomicelles when interacting with gastrointestinal fluids. Canagliflozin, a sodium-glucose cotransporter-2 inhibitor for treating type 2 diabetes, has been linked to poor absorption due to its insolubility in aqueous media. The study aimed to create self-nanomicellizing solid dispersion systems for canagliflozin to overcome its pharmaceutical limitations and improve oral bioavailability.

Materials and Methods: Soluplus® was chosen as a nanocarrier to improve canagliflozin solubility after screening several polymers using a phase solubility study. The solvent evaporation method was selected for preparing the solid dispersion. The optimal formula was characterized through ex vivo permeability and in vitro studies.

Results: The CFZ-SNMSD formula, with a particle size PS of 60.77±1.00 nm and polydispersity index PDI of 0.06±0.02, has a stable distribution upon dilution to 20-fold with water. The apparent solubility of canagliflozin in the optimized CFZ-SNMSD formula was enhanced by 904.40±4 folds due to amorphization and nanomicellization, as demonstrated by transmission electron microscopy. CFZ-SNMSD formula showed a significant enhancement in dissolution rate compared to the physical mixture and pure drugs. The dissolution efficiency parameter confirms these findings (DE30, CFZ-SNMSD = 77.20% compared to DE30, pure drug = 18.28%). Studies show that canagliflozin’s permeability increases exponentially over time due to Soluplus® dispersibility, solubilization, and glycoprotein inhibitory effect, enhancing bioavailability and overcoming GIT membrane barriers. Conclusions: The study indicates that canagliflozin self-nanomicellizing solid dispersion systems are promising methods for improving the oral bioavailability of canagliflozin medication.
Cannabidiol, a promising therapy for post-traumatic stress disorder and depression. A mini-review
Authors: Jîtcă George 
Published: July 2024

Abstract
Post-traumatic stress disorder (PTSD) is a mental health disorder, manifesting in people who have endured traumatic events like violence, war, natural disasters, accidents, or other life-threatening situations. Essentially, PTSD is a chronic and debilitating disorder, significantly impacting mental health and psychosocial well-being, necessitating the exploration of novel treatment approaches. Although conventional therapies like psychotherapy and antidepressants have demonstrated efficacy for certain individuals, their effectiveness is limited for some and minimal for others. Consequently, researchers and clinicians are investigating alternative therapeutic methods for these conditions. Among these emerging treatments, cannabidiol (CBD) has shown promising results. Nevertheless, early studies suggest that CBD might yield positive outcomes in mitigating symptoms related to both depression and PTSD.
Business Models of Enterprises in the Conditions of Digital Transformation: Global and Domestic Experience
Authors: Shostak Liudmyla , Lipych Liubov , Anatolii Fedoniuk , Volynets Iryna , Andrew Ulyanytsky , Morokhova Valentyna 
Published: July 2024

Abstract
The article aims to provide a comprehensive overview of both theoretical concepts and practical applications regarding the transformation of business models in the context of digitalizing the economy. In the current digital landscape, traditional business models may no longer suffice to sustain growth and competitiveness. Therefore, there is a pressing need to identify and adopt novel approaches that leverage digital technologies to their fullest potential. By examining the latest trends and emerging paradigms in economy’s, the article aims to re-think their strategies and embrace digital transformation proactively. This involves not only incorporating technology into existing operations but also reimagining the entire business model to capitalize on new opportunities and address evolving consumer behaviors. Furthermore, the article aims to provide practical insights and actionable recommendations for businesses looking to embark on their digital transformation journey.
The Impact of Inflation on Financial Sector Performance: Evidence from OECD Countries
Authors: Bilalli Argjira , Sadiku Murat , Sadiku Luljeta 
Published: July 2024

Abstract
This research article investigates the relationship between inflation and the performance of the financial sector within OECD countries, a group critical to global economic stability. The financial sector is a basis of sustainable economic growth, and its performance is heavily influenced by the macroeconomic environment, particularly inflation. This study analyses how inflation, alongside other significant factors such as real GDP growth, government size, trade openness, and interest rates, impacts the financial sector development. By examining data from 38 OECD countries over a 20-year period (2002-2021), this research employs a comprehensive approach using both static and dynamic panel regression models. The results consistently indicate a negative correlation between inflation and the key financial sector variables, suggesting that higher inflation levels undermine financial sector performance. These findings underscore the importance of maintaining low and stable inflation to foster an efficient and stable financial sector. This study makes a valuable contribution to the literature by focusing specifically on OECD countries, which are often seen as benchmarks for economic policies and financial systems.
Researches on the Mobility and Toxicity of Heavy Metals from Balomir Tailings Dump – Uricani Jiu Valley
Authors: Ioniţă Mădălina-Flavia , Radu Sorin Mihai , Dunca Emilia Cornelia 
Published: July 2024

Abstract
Coal mining is a vital industrial activity but often associated with negative environmental effects, including the accumulation of waste containing heavy metals in tailings dump. These heavy metals, such as lead, chromium, copper, zinc, cadmium, mercury, and others, pose significant risks to the environment and human health. The mobility of these heavy metals is a major concern, as they can be released into soil and water during rain or erosion processes, contaminating water sources and affecting aquatic and terrestrial life. These metals can be taken over by plants and eventually end up in the trophic chain, including in humans. The toxicity of heavy metals is well known, with these substances having harmful effects on human health. In this paper, the main ways of transferring heavy metals into environmental components and their spatial distribution from sterile holes to water and soil environment components. As a case study, the sterile Balomir hole, an inactive hole for about 9 years resulting from the exploitation of the hule from the Uricani mine located in the Jiu Valley.
Diagnosing the Issue: Understanding and Combating Medical Brain Drain in Bosnia and Herzegovina
Authors: Jahić Hatidža , Hadžiahmetović-Milišić Nejra , Dedović Lejla , Kuloglija Emina 
Published: July 2024

Abstract
This study investigates emigration patterns among healthcare professionals in Bosnia and Herzegovina, examining the underlying reasons for emigration and proposing actionable solutions to curb this trend. A mixed-methods approach is employed, combining quantitative data from surveys administered to medical and health studies students with qualitative insights from interviews with governmental officials, language educators, and statistical agencies. The findings reveal significant dissatisfaction with socio-economic and political conditions, prompting healthcare professionals to seek opportunities abroad. Major reasons for going abroad include political instability, low wages, and poor working conditions, while better pay and career opportunities are attracting factors. While the study is limited by the lack of comprehensive official statistics on emigration, the implications of this research emphasize the need for policy interventions aiming to improve local working conditions and reform educational systems. The study provides valuable insights for policymakers and stakeholders to effectively address the issue of brain drain.
Consumer Preferences and Reactions to Brand Expansion
Authors: Vuković Dijana , Kerum Fani , Žukina Miroslava 
Published: July 2024

Abstract
Consumer purchasing power is one of the key determinants of consumer behavior, among other factors. Acceptance of new brands or product line extensions of existing brands is influenced by perceived value. New products can be added to existing product lines by introducing new products within them, or brands can expand horizontally by entering entirely new categories or product lines. Any vertical expansion, whether to a higher or lower level, comes after a price shift and a product quality achievement relative to its base product. While survey-based research provides valuable insights that support the growth of the Premium brand, building a strong relationship with customers, quickly identifying preferences, personalizing the offer and fostering a climate of trust remain its main sources of value. The purpose of the paper is to show the positive relationship that exists between the vertical growth of the brand and the increase in customer loyalty, as shown by the research conducted on a deliberate sample.
Do Wages Follow Productivity? Evidence from European Countries
Authors: Kosuliev Aleksandar 
Published: July 2024

Abstract
Economic theory assumes that factors are paid according to their marginal productivity, however the empirical validity of this hypothesis has been questioned in some of the literature. We use data from Eurostat to examine the changes of labour remuneration and labour productivity during the period 2004-2020 in a panel of European countries. The results from the panel regression analysis confirm that in general there is a strong link between labour productivity and the compensation of employees. However, exploratory analysis shows that the sample is characterized with internal heterogeneity. Growth is higher in Central and Eastern Europe and for some countries from the region there is decoupling of productivity and labour remuneration. The latter has seen stronger growth, with the exception of Romania, where in real terms productivity has been growing faster than wages. Possible explanations of the decoupling are catching up and convergence, integration in the world economy, factor mobility, difference in labour market institutions and excessive labour demand, but the present research is inconclusive.