bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigued individuals show increased conformity in virtual meetings
Authors: Masjutin Lisa , Bangemann Anne , Reimann Leonie , Maier Günter W. 
Published: August 2024

AbstractVirtual meetings are widespread in organizations despite being perceived as fatiguing; a phenomenon also known as Zoom fatigue. Research suggests that Zoom fatigue is stronger when the camera is on, potentially influencing individuals to conform to majority opinions during professional online meetings. Two preregistered studies were conducted to explore the relationships between camera use, Zoom fatigue, social presence, and conformity. Study 1 involved 287 participants describing a professional online meeting in terms of the content discussed as well as the study variables. Study 2 involved 64 participants in an experimentally manipulated online meeting (camera on vs. off), focusing on a personnel selection task. We measured how many times participants changed their answers to match the majority and how this was related to Zoom fatigue and self-reported conformity. Results from both studies indicated that camera use was not related to either conformity or Zoom fatigue. Despite not finding the presumed mediation effect, the studies showed a clear link between fatigue and conformity. The results explain the emergence of conformity in online meetings and provide practical information for the design of video conferences.
Contrasting effects of intracellular and extracellular human PCSK9 on inflammation, lipid alteration and cell death
Authors: Ghalali Aram , Alhamdan Fahd , Upadhyay Swapna , Ganguly Koustav , Larsson Kjell , Palmberg Lena , Rahman Mizanur 
Published: August 2024

AbstractProprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the major regulators of low-density lipoprotein receptor (LDLR). Information on role and regulation of PCSK9 in lung is very limited. Our study focuses on understanding the role and regulation of PCSK9 in the lung. PCSK9 levels are higher in Bronchoalveolar lavage fluid (BALF) of smokers with or without chronic obstructive pulmonary diseases (COPD) compared to BALF of nonsmokers. PCSK9-stimulated cells induce proinflammatory cytokines and activation of MAPKp38. PCSK9 transcripts are highly expressed in healthy individuals compared to COPD, pulmonary fibrosis or pulmonary systemic sclerosis. Cigarette smoke extract reduce PCSK9 levels in undifferentiated pulmonary bronchial epithelial cells (PBEC) but induce in differentiated PBEC. PCSK9 inhibition affect biological pathways, induces lipid peroxidation, and higher level of apoptosis in response to staurosporine. Our results suggest that higher levels of PCSK9 in BALF acts as an inflammatory marker. Furthermore, extracellular and intracellular PCSK9 play different roles.
Helicobacter pylori and Campylobacter jejuni bacterial holocytochrome c synthase structure-function analysis reveals conservation of heme binding
Authors: Yeasmin Tania , Carroll Susan C. , Hawtof David J. , Sutherland Molly C. 
Published: August 2024

AbstractHeme trafficking is essential for cellular function, yet mechanisms of transport and/or heme interaction are not well defined. The System I and System II bacterial cytochrome c biogenesis pathways are developing into model systems for heme trafficking due to their functions in heme transport, heme stereospecific positioning, and mediation of heme attachment to apocytochrome c. Here we focus on the System II pathway, CcsBA, that is proposed to be a bi-functional heme transporter and holocytochrome c synthase. An extensive structure-function analysis of recombinantly expressed Helicobacter pylori and Campylobacter jejuni CcsBAs revealed key residues required for heme interaction and holocytochrome c synthase activity. Homologous residues were previously identified to be required for heme interaction in Helicobacter hepaticus CcsBA. This study provides direct, biochemical evidence that mechanisms of heme interaction are conserved, leading to the proposal that the CcsBA WWD heme-handling domain represents a novel target for therapeutics.
Food-sourcing from on-farm trees mediates positive relationships between tree cover and dietary quality in Malawi
Authors: Vansant Emilie , den Braber Bowy , Hall Charlotte , Kamoto Judith , Reiner Florian , Oldekop Johan , Rasmussen Laura Vang 
Published: August 2024

AbstractFood security policies often overlook the potential of trees to provide micronutrient-rich foods. Here, through causal mediation analysis, we show the positive effect of tree cover on micronutrient adequacy, explained by people sourcing food from on-farm trees. Detailed survey data (n = 460 households with repeated surveys) from Malawi were linked to high-resolution (3 m) tree-cover data to capture forest and non-forest trees. Our findings support integrating nutrition and landscape restoration policies.
Valproic acid targets IDH1 mutants through alteration of lipid metabolism
Authors: Elahi Lubayna S. , Condro Michael C. , Kawaguchi Riki , Qin Yue , Alvarado Alvaro G. , Gruender Brandon , Qi Haocheng , Li Tie , Lai Albert , Castro Maria G. , Lowenstein Pedro R. , Garrett Matthew C. , Kornblum Harley I. 
Published: August 2024

Abstract
Histone deacetylases (HDACs) have a wide range of targets and can rewire both the chromatin and lipidome of cancer cells. In this study, we show that valproic acid (VPA), a brain penetrant anti-seizure medication and histone deacetylase inhibitor, inhibits the growth of IDH1 mutant tumors in vivo and in vitro, with at least some selectivity over IDH1 wild-type tumors. Surprisingly, genes upregulated by VPA showed no enhanced chromatin accessibility at the promoter, but there was a correlation between VPA-downregulated genes and diminished promoter chromatin accessibility. VPA inhibited the transcription of lipogenic genes and these lipogenic genes showed significant decreases in promoter chromatin accessibility only in the IDH1 MT glioma cell lines tested. VPA inhibited the mTOR pathway and a key lipogenic gene, fatty acid synthase (FASN). Both VPA and a selective FASN inhibitor TVB-2640 rewired the lipidome and promoted apoptosis in an IDH1 MT but not in an IDH1 WT glioma cell line. We further find that HDACs are involved in the regulation of lipogenic genes and HDAC6 is particularly important for the regulation of FASN in IDH1 MT glioma. Finally, we show that FASN knockdown alone and VPA in combination with FASN knockdown significantly improved the survival of mice in an IDH1 MT primary orthotopic xenograft model in vivo. We conclude that targeting fatty acid metabolism through HDAC inhibition and/or FASN inhibition may be a novel therapeutic opportunity in IDH1 mutant gliomas.
Thyroid hormone receptor beta (THRB) dependent regulation of diurnal hepatic lipid metabolism in adult male mice
Authors: de Assis Leonardo Vinicius Monteiro , Harder Lisbeth , Inderhees Julica , Jöhren Olaf , Mittag Jens , Oster Henrik 
Published: August 2024

AbstractThyroid hormones (THs) are critical regulators of systemic energy metabolism and homeostasis. In the liver, high TH action protects against steatosis by enhancing cholesterol and triglyceride turnover, with thyroid hormone receptor beta (THRB) signaling playing a pivotal role. This study probed the potential interaction between THRB action and another critical regulator of liver energy metabolism, the circadian clock. Liver transcriptome analysis of THRB deficient (THRBKO) mice under normal chow conditions revealed a modest impact of THRB deletion. Temporal transcriptome and lipidome profiling uncovered significant alterations in diurnal metabolic rhythms attributable to THRB deficiency pointing to a pro-steatotic state with elevated levels of cholesterol, tri- and diacylglycerides, and fatty acids. These findings were confirmed by THRB agonization in hepatocytes under steatosis-promoting conditions in vitro. Integration of transcriptome profiles from THRBKO mice and mice with induced high or low TH action identified a subset of TH responsive but THRB insensitive genes implicated in immune processes. In summary, our study reveals a complex time-of-day dependent interaction of different TH-related signals in the regulation of liver physiology indicating an opportunity for chronopharmacological approaches to TH/THRB manipulation in fatty liver diseases.
TGFβ1, SMAD and β-catenin in pulmonary arteries of smokers, patients with small airway disease and COPD: potential drivers of EndMT
Authors: Bhattarai Prem , Lu Wenying , Hardikar Ashutosh , Gaikwad Archana Vijay , Dey Surajit , Shahzad Affan Mahmood , Myers Stephen , Williams Andrew , Sutherland Darren , Singhera Gurpreet Kaur , Hackett Tillie-Louise , Eapen Mathew S. , Sohal Sukhwinder Singh 
Published: August 2024

Abstract
We previously reported pulmonary arterial remodelling and active endothelial-to-mesenchymal transition (EndMT) in smokers and patients with early chronic obstructive pulmonary disease (COPD). In the present study, we aimed to evaluate the role of different drivers of EndMT. Immunohistochemical staining for EndMT drivers, TGF-β1, pSMAD-2/3, SMAD-7, and β-catenin, was performed on lung resections from 46 subjects. Twelve were non-smoker-controls (NC), six normal lung function smokers (NLFS), nine patients with small-airway diseases (SAD), nine mild-moderate COPD-current smokers (COPD-CS) and ten COPD-ex-smokers (COPD-ES). Histopathological measurements were done using Image ProPlus softwarev7.0. We observed lower levels of total TGF-β1 (P&lt;0.05) in all smoking groups than in the non-smoking control (NC). Across arterial sizes, smoking groups exhibited significantly higher (P&lt;0.05) total and individual layer pSMAD-2/3 and SMAD-7 than in the NC group. The ratio of SAMD-7 to pSMAD-2/3 was higher in COPD patients compared with NC. Total β-catenin expression was significantly higher in smoking groups across arterial sizes (P&lt;0.05), except for COPD-ES and NLFS groups in small and medium arteries, respectively. Increased total β-catenin was positively correlated with total S100A4 in small and medium arteries (r = 0.35, 0.50; P=0.02, 0.01, respectively), with Vimentin in medium arteries (r = 0.42, P=0.07), and with arterial thickness of medium and large arteries (r = 0.34, 0.41, P=0.02, 0.01, respectively). This is the first study uncovering active endothelial SMAD pathway independent of TGF-β1 in smokers, SAD, and COPD patients. Increased expression of β-catenin indicates its potential interaction with SMAD pathway, warranting further research to identify the deviation of this classical pathway.
Maternal high-fat diet regulates offspring hepatic ABCG5 expression and cholesterol metabolism via the gut microbiota and its derived butyrate
Authors: Zhang Ling , Zhang Shixuan , Zou Wenyu , Hu Yongyan , Gao Ying , Zhang Junqing , Zheng Jia 
Published: August 2024

Abstract
Maternal high-fat diet intake has profound effects on the long-term health of offspring, predisposing them to a higher susceptibility to obesity and metabolic dysfunction-associated steatotic liver disease. However, the detailed mechanisms underlying the role of a maternal high-fat diet in hepatic lipid accumulation in offspring, especially at the weaning age, remain largely unclear. In this study, female C57BL/6J mice were randomly assigned to either a high-fat diet or a control diet, and lipid metabolism parameters were assessed in male offspring at weaning. Gut microbiota analysis and targeted metabolomics of short-chain fatty acids (SCFAs) in these offspring were further performed. Both in vivo and in vitro studies were conducted to explore the role of butyrate in hepatic cholesterol excretion in the liver and HepG2 cells. Our results showed that maternal high-fat feeding led to obesity and dyslipidemia, and exacerbated hepatic lipid accumulation in the livers of offspring at weaning. We observed significant decreases in the abundance of the Firmicutes phylum and the Allobaculum genus, known as producers of SCFAs, particularly butyrate, in the offspring of dams fed a high-fat diet. Additionally, maternal high-fat diet feeding markedly decreased serum butyrate levels and down-regulated ATP-binding cassette transporters G5 (ABCG5) in the liver, accompanied by decreased phosphorylated AMP-activated protein kinase (AMPK) and histone deacetylase 5 (HADC5) expressions. Subsequent in vitro studies revealed that butyrate could induce ABCG5 activation and alleviate lipid accumulation via the AMPK-pHDAC5 pathway in HepG2 cells. Moreover, knockdown of HDAC5 up-regulated ABCG5 expression and promoted cholesterol excretion in HepG2 cells. In conclusion, our study provides novel insights into how maternal high-fat diet feeding inhibits hepatic cholesterol excretion and down-regulates ABCG5 through the butyrate-AMPK-pHDAC5 pathway in offspring at weaning.
Optimal eco‐emission scheduling of the reconfigurable solar farm‐based combined hydrogen, heat, and power (RSF‐CHHP)
Authors: Baghaei Ali , Olamaei Javad , Nasiri Mohammad Reza 
Published: August 2024

AbstractCombined hydrogen, heat, and power (CHHP) is the cogeneration unit simultaneously meeting hydrogen, heat, and power demands. Due to the low efficiency of the electrolyser, the main grid or other generation units supply its input power. Herein, the photovoltaic farm's (PV farm) output power is used as the input power of the electrolyser. Optimal economic and emission scheduling of CHHP‐based microgrid (CHHP_MG) is defined as an objective function. To improve system efficiency, the scheduling problem is done in two cases, reconfigured SP‐PV farm and conventional SP‐PV farm. To optimal management of both demand and generation sides, a time of use (TOU) based demand response program is employed in the proposed short‐term study. To have a comprehensive study, the optimum solar panel tilt angle is calculated, and its impacts on the main function are analysed. Multi‐objective genetic algorithm is used to solve optimization problems. By solving the objective function, the obtained values for profit and pollution amount are 620$ and 69,245.78 gr, respectively. By applying the load response program, the mentioned values are changed to 715.132$ and 6872.5 gr. Since the input power is supplied through solar panels, the placement angle of the panels is very important and with the optimal setting of the placement angle, the values change to 780$ and 6825.3 gr.
Robust predictive control strategy for grid‐connected inverters with ultra‐local model based on linear matrix inequality
Authors: Liu Chunxi , Hong Fangrui , Liu Zhile , Zhou Li , Jin Xuanxu , Lin Zhiwei 
Published: August 2024

AbstractTo address the issue of poor robustness in the model predictive control of grid‐connected inverters due to disturbances in load model parameters, this article developed an ultra‐local model robust predictive controller based on Linear Matrix Inequality (LMI). First, to avoid dependence on model parameters, an ultra‐local model of the system was constructed. Second, in the process of setting the state variable compensation gain, to simplify the complex computational steps of the traditional Lyapunov algorithm, the task of finding the gain that satisfies the Lyapunov stability condition was ingeniously transformed into an optimization problem of solving constrained LMI. Third, the optimized state variables are utilized to design a new cost function predictive model, thereby enhancing the precision of system control. Finally, the effectiveness of the proposed approach has been validated through simulations and experiments.
Multi-transition study of methanol towards NGC 1068 with ALMA
Authors: Huang K.-Y. , Abbink D. , Viti S. , García-Burillo S. 
Published: August 2024

Context. The outflowing molecular gas in the circumnuclear disc (CND) of the nearby (D = 14 Mpc) AGN-starburst composite galaxy NGC 1068 is considered as a manifestation of ongoing AGN feedback. The large spread of velocities from the outflowing gas is likely driving various kinds of shock chemistry across the CND.
Aims. We performed a multiline molecular study using CH3OH with the aim of characterizing the gas properties probed by CH3OH in the CND of NGC 1068 and investigating its potential association with molecular shocks.
Methods. Multi-transition CH3OH were imaged at the resolution of 0.″5 − 0.″8 with the Atacama Large Millimeter/submillimeter Array (ALMA). We performed a non-LTE radiative transfer analysis coupled with a Bayesian inference process in order to determine the gas properties such as the gas volume density and the gas kinetic temperature.
Results. The gas densities traced by CH3OH point to ∼106 cm–3 across all the CND regions. The gas kinetic temperature cannot be well constrained in any of the CND regions, though the inferred temperature is likely low (≲100 K).
Conclusions. The low gas temperature traced by CH3OH suggests shocks and subsequent fast cooling as the origin of the observed gas-phase CH3OH abundance. We also note that the E-/A-isomer column-density ratio inferred is fairly close to unity, which is, interestingly, different from the Galactic measurements in the literature. It remains inconclusive whether CH3OH exclusively traces slow and non-dissociative shocks, or whether the CH3OH abundance can actually be boosted in both fast and slow shocks.
X-ray occultations in active galactic nuclei: Physical properties of eclipsing clouds as part of the broad-line region cloud ensemble
Authors: Pietrini P. , Torricelli-Ciamponi G. , Risaliti G. 
Published: August 2024

Context. Short-term X-ray variability in active galactic nuclei (AGNs) can be explained as being due to varying X-ray absorption induced by the temporary occultation of the primary X-ray source, when moving absorbing clouds cross the line of sight to the X-ray source itself. Earlier work suggests that these absorbing clouds have physical properties similar to those of broad-line region (BLR) emitting clouds and are located in the same spatial region.
Aims. We intend to extract physical information on each individual absorber associated with any given occultation event detected in our sample and to analyse general properties of the cloud ensemble whose components can produce X-ray eclipses.
Methods. From the analysis of previously detected occultation events, two ‘observables’ characterising each single occultation event can be derived: the peak fractional hardness ratio variation (ΔHR/HR) and the duration of the event normalised by a characteristic eclipse timescale evaluated for each AGN source. To determine the eclipsing cloud properties, we devised a procedure a) based on simplifying assumptions on the geometry of both the X-ray source and the cloud-like gas condensations, and on the cloud X-ray absorbing properties in the energy range of interest (2–10 keV), and b) relying on a set of simulated instrumental responses from both XMM and Suzaku relevant instruments to different incoming X-ray spectra, absorbed with varying absorber column density and maximum covering factor during the occultation. Thus, we derived information on the individual cloud producing any given occultation event, determining the cloud radius normalised to that of the X-ray source, the spatial location of the cloud, and an estimate of the cloud gas number density for reasonable values of the equivalent absorber column density.
Results. The physical properties of eclipsing clouds that we obtained are consistent with those of BLR clouds. We can exclude the dominance, in the ensemble cloud size distribution, of clouds larger than about 10–12 times the Schwarzschild radius characterising each AGN, and we do not find any significant dependence of the cloud physical size on the distance from the central black hole, in agreement with the results of our previous work. As for the number density of these gas condensations, with our procedure we obtained values within a range of ∼109 − 1011 cm−3, which is consistent with the estimates derived from broad emission line analysis.
Radiation mechanism of twin kilohertz quasi-periodic oscillations in neutron star low-mass X-ray binaries
Authors: Shi Chang-Sheng , Zhang Guo-Bao , Zhang Shuang-Nan , Li Xiang-Dong 
Published: August 2024

Context. The connection between quasi-periodic oscillations (QPOs) and magnetic fields has been investigated in various celestial bodies. Magnetohydrodynamic (MHD) waves have been employed to explain the simultaneous upper and lower kilohertz (kHz) QPOs. Nevertheless, the intricate and undefined formation pathways of twin kHz QPOs present a compelling avenue for exploration. This study area holds great interest as it provides an opportunity for deriving crucial parameters related to compact stars.
Aims. We strive to develop a self-consistent model elucidating the radiation mechanism of twin kHz QPOs, which we then compare it with observations.
Methods. A sample of 28 twin kHz QPOs detected from the X-ray binary 4U 1636–53 was used for a comparison with the results of the Markov chain Monte Carlo calculations based on our model of the radiation mechanism of twin kHz QPOs, which is related to twin MHD waves.
Results. We obtained 28 groups of parameters of 4U 1636–53 and a tight exponential fit between the flux and the temperature of seed photons to Compton up-scattering and find that the electron temperature in the corona around the neutron star decreases with increasing seed photon temperature.
Conclusions. The origin of twin kHz QPOs are dual disturbances that arise from twin MHD waves that are generated at the innermost radius of an accretion disc. The seed photons can be transported through a high temperature corona and are Compton up-scattered. The photons that vary the frequencies of twin MHD waves lead to the observed twin kHz QPOs.
ZTF SN Ia DR2: Evidence of changing dust distribution with redshift using type Ia supernovae
Authors: Popovic B. , Rigault M. , Smith M. , Ginolin M. , Goobar A. , Kenworthy W. D. , Ganot C. , Ruppin F. , Dimitriadis G. , Johansson J. , Amenouche M. , Aubert M. , Barjou-Delayre C. , Burgaz U. , Carreres B. , Feinstein F. , Fouchez D. , Galbany L. , de Jaeger T. , Kim Y.-L. , Lacroix L. , Nugent P. E. , Racine B. , Rosselli D. , Rosnet P. , Sollerman J. , Hale D. , Laher R. , Müller-Bravo T. E. , Reed R. , Rusholme B. , Terwel J. 
Published: August 2024

Context. Type Ia supernova (SNIa) are excellent probes of local distance and the growing sample sizes of SNIa have driven an increased propensity to study the associated systematic uncertainties and improve standardisation methods in preparation for the next generation of cosmological surveys into the dark energy equation of state, w.
Aims. We aim to probe the potential change in the SNIa standardisation parameter, c, with redshift and the host-galaxy of the supernova. Improving the standardisation of SNIa brightness measurements will require the relationship between the host and the SNIa to be accounted for. In addition, potential shifts in the SNIa standardisation parameters with redshift will cause biases in the recovered cosmology.
Methods. In this work, we assembled a volume-limited sample of 3000 likely SNIa across a redshift range from z = 0.015 to z = 0.36. This sample was fitted with changing mass and redshift bins to determine the relationship between the intrinsic properties of SNe Ia and their redshift and host galaxy parameters. We then investigated the colour-luminosity parameter, β, as a subsequent test of the SNIa standardisation process.
Results. We find that the changing colour distribution of SNe Ia with redshift is driven by dust at a confidence of > 4σ. Additionally, we show a strong correlation between the host galaxy mass and the colour-luminosity coefficient β (> 4σ), even when accounting for the quantity of dust in a host galaxy.
Conclusions. These results indicate that the observed colour distribution of SNe Ia does change with redshift. However, we note that this is an observational effect, rather than an intrinsic change. Future cosmological measurements with SNe Ia must take into account these changing dust distributions to reduce the number of potential sources of systematic uncertainty.