bluuebunny/crossref_metadata_2025_split huggingface dataset:
P-481 THE LACK OF INTEGRITY IN THE IAEA’S REVIEW REPORT ON THE OCEAN DUMPING OF FUKUSHIMA CONTAMINATED WASTE
Authors: Paek Domyung , Choi MooYoung 
Published: July 2024

Abstract

Introduction
In July 2023, the International Atomic Energy Agency (IAEA) issued a final report on its review of the ocean dumping plan for contaminated water from the Fukushima Daiich Nuclear Power Plant in Japan. According to the report, the IAEA did not verify the ocean dumping plan proposed by the Japanese government; instead, the IAEA reviewed whether the Japanese government’s explanation of its policy met the expression of international safety standards. Specifically, despite the Japanese government’s selection plan based on indirect circumstantial evidence, the IAEA did not provide its own perspective on the list of possible nuclides to be identified in the waste.

Methods
This is internally inconsistent with the IAEA’s own principle for selection, and contradicts its previous position of verifying the principle in advance. Moreover, it is worrying that the IAEA acknowledges the Japanese government’s approach to evaluating the post-dilution situation without considering the existing risks from the 2011 contamination.

Results
This approach views post-dilution dumping as a planned exposure and ignores possible increases in existing risks due to even minor additional events, such as sudden changes in the ecosystem.

Discussion
In addition, the uncertainties resulting from environmental changes, such as the climate crisis and variations in ocean currents and biota migration, have not been taken into account.These uncertainties and others, especially the non-target effects of prolonged, long-term exposure, should have been evaluated.

Conclusion
It is crucial to recognize that safety is a comprehensive concept and cannot be assessed by matching individual criteria one by one.
P-540 ASSOCIATION BETWEEN OCCUPATIONAL ACCIDENTS AND EMPLOYEE TURNOVER
Authors: Jinnouchi Takahiro , Nagata Tomohisa , Odagami Kiminori , Adi Nuri Purwito , Mori Koji 
Published: July 2024

Abstract

Introduction
This study aimed to examine the relationship between occupational accidents and employee turnover.

Methods
We conducted an online self-administered questionnaire survey to workers aged 20 years old or more in Japan in March 2022, followed by a second survey in March 2023 (prospective cohort study). Participants were segmented into two groups: those who had experienced occupational accidents in the preceding year (group 1) and those who had not (group 2). Employee turnover was defined as cessation of employment between the two survey periods. We examined the relationship between occupational accidents and employee turnover using logistic regression analysis. This study was approved by the Ethics Committee of the UOEH.

Results
Of the 16,629 respondents, 890 reported an occupational accident at baseline. Compared to group 2, the odds ratios for employee turnover were 1.83 (1.59-2.01) for group 1. Working in a large company (OR=0.81, 95%CI: 0.74-0.89) and receiving support from supervisors (OR=0.97, 95%CI: 0.96-0.99) were factors associated with reduced employee turnover due to occupational accidents.

Discussion
The study reveals a significant relationship between occupational accidents and employee turnover, with other factors also playing a role. Despite providing crucial insights, the study acknowledges its limitations, including the restricted number of data points collected.

Conclusion
The study suggests that measures aimed at reducing occupational accidents and bolstering supervisors support could be effective strategies to avert employee turnover.
P-545 QUALITY OF LIFE AMONG VICTIMS OF WORK-RELATED UPPER EXTREMITY INJURIES
Authors: Haddar Aicha , Sellami Imen , Ghrab Mohamed Anis , Masmoudi Mohamed Larbi , Hammami Kaouthar Jmal , Hajjaji Mounira , Haddar Aicha , Hrairi Anouare 
Published: July 2024

Abstract

Introduction
Work-related upper extremity injuries (WRUEI) have serious consequences on the victim’s life. These accidents can result in physical, mental, and aesthetic damage that affects life of victims. We aimed to evaluate factors affecting the quality of life (QOL) among victims of WRUEI.

Methods
We conducted a cross-sectional Study on occupational accident victims. Data were collected using a pre-established questionnaire. The QOL was assessed using the 12-item Short Form Health Survey (SF-12) which includes a physical component summary (PCS) and mental component summary (MCS) scores. We evaluated the pain level using Visual Analogue Scale (VAS).

Results
Ninety patients with WRUEI were evaluated. The mean age was 43 ±9.9 years. The male-to-female sex ratio was 3.7. Injuries of dominant members represented 62% of cases. The most affected areas were the hand and wrist (63% of cases). The mean VAS score was 5.7± 2.8. The mean PCS and MCS scores were 34±6.1 and 44±10.7 respectively. PCM score was associated with pain level (r=-0.42; p&lt;0.001), undergoing rehabilitation (p=0.025), duration of immobilization (r= -0.31; p=0.003), and the impairment rate (r=-0.27; p=0.009). MCS score was associated with non-dominant upper limb injuries (p= 0.02), duration of absence (r= 0.25; p=0.015), and pain level (r=-0.39; p&lt;0.001).

Discussion
Providing adequate care and interventions is crucial to enhancing the QOL for this vulnerable population. Pain management can improve both component of the QOL.

Conclusion
This study highlighted factors interfering with the QOL of victims of WRUEI. Different stakeholders should consider those factors when providing care to this vulnerable population.
P-564 NOISE-RELATED HEARING DISORDER AMONG VECTOR CONTROL WORKERS IN KUALA LUMPUR
Authors: Yap Kian Kiong 
Published: July 2024

Abstract

Introduction
The most common occupational ailment in Malaysia and a significant compensable occupational hazard is noise-related hearing disorder (NRHD). The need for vector control personnel to stop the spread of dengue at the expense of exposure to loud fogging machines has become more urgent as the number of dengue cases has increased.

Methods
A cross-sectional study of vector control personnel from a local government in Kuala Lumpur was carried out. Participants were divided into those who were directly involved in fogging activities, and those who were not. To collect sociodemographic, medical, and occupational data, a self-administered questionnaire was used. An audiogram test confirmed the diagnosis of NRHD.

Results
The prevalence of NRHD was observed to be high (51.4%) among vector control personnel exposed to fogging activity (occupational noise risks). Fogging status, sex and age were predictors of NRHD.

Discussion
As the noise level of fogging machines exceeded &gt; 90dB(A) at a distance of 0.5m, there is a definite correlation between fogging activities and NRHD. Especially among noise-exposed workers, physiological changes to the inner ear that take place as people age may hasten the onset of NRHD. The bulk of the blue-collar vector control personnel were male because historically, men have dominated physical labour, high-noise industries, and occupations. This led to the establishment of gender as a predictor.

Conclusion
These results highlight the significant effect of workplace noise hazards on NRHD and highlight the necessity to address this issue in order to protect employees’ health, especially among male and older workers who have chronic noise exposure.
O-382 NEED FOR WOMEN-CENTRIC MENTAL HEALTH POLICY AS OSH COMPONENT
Authors: Pandey Manisha 
Published: July 2024

Abstract

Introduction
Safety and health at work are fundamental to economic growth; and mental health issues are being recognized as a major health hazard.Sadly,very little attention is paid to assessing risks and hazards from a women-specific mental health perspective, despite a growing number of female employees.

Method
The purpose of this study, conducted on women employees of a PSU company, is to identify and analyze the impact of women specific factors on mental health at workplace, through questionnaires and interviewing.

Results
Mental health is affected by phases of a woman’s life like menstruation, pregnancy, lactation, menopause and diseases like PCOD, infertility,and cancers,apart from worklife balance issues.Significant correlation was found between mental health and menstrual/ gynaecological ailments. While only 28% perceived themselves in excellent mental state; 10% had training in mental or occupational health.48% women experienced some sort of gender discrimination and career opportunities were lost if they had to take special leave to care for their families.

Discussion
While women bear the dual stress of juggling career demands with family responsibilities, job issues like long working hours, informal working arrangements,gender discrimination, bullying,sexual harassment and third-party violence along with insensitivity to womanly problems harms mental health and productivity. Fewer women are in senior leadership positions because of glass ceiling effect; toxic and insensitive work environment, lack of career opportunities causing low self-esteem and culminating in mental illness.

Conclusion
Like any other diversity inclusion exercise, the impact of gender specific mental health on all OSH policies has to be assessed.
P-590 SICKNESS-RELATED ABSENTEEISM AND PSYCHOLOGICAL DISTRESS AMONG PATIENTS WITH PHYSICAL DISEASE AFTER RETURN-TO-WORK: A CROSS SECTIONAL STUDY IN JAPANESE HOSPITAL
Authors: Furue Akiko , Harada Arisa , Tateishi Seiichiro , Nagata Masako 
Published: July 2024

Abstract

Introduction
The association between sickness-related absenteeism and psychological distress were reported; however, its association among patients with physical disease after return-to-work (RTW) remains unclear. This study aimed to assess the association between sickness-related absenteeism and psychological distress in physical disease patients after RTW.

Methods
This cross-sectional study analyzed self-administered questionnaires from patients visiting a Japanese hospital between August 2021 and March 2022. The study included 168 employed individuals who reported RTW during the survey. Logistic regression was used to analyze the association between sickness-related absenteeism and psychological distress in physical disease patients after RTW.

Results
Of the 168 participants (mean age: 50.4 years, 41.1% male, 48.2% Neoplasms), 54.8% reported experiencing sickness-related absenteeism after RTW. After adjusting for age and gender, sickness-related absenteeism was significantly associated with psychological distress in physical disease patients after RTW (odds ratio: 2.19, 95% confidence interval: 1.02-4.70).

Discussion
Sickness-related absenteeism was associated with psychological distress in physical disease patients after RTW. Absenteeism can lead to a reduction in patients’ income and loss of workforce for companies, imposing a burden on both workers and employers. It remains unclear whether sickness-related absenteeism leads to psychological distress or vice versa. In both cases, psychological support benefits for patients experiencing sickness-related absenteeism after RTW.

Conclusion
Patients with physical disease after RTW need support to receive treatment while continuing to work. In particular, psychological support benefits for patients with sickness-related absenteeism.
Selectivity filter mutations shift ion permeation mechanism in potassium channels
Authors: Mironenko Andrei , de Groot Bert L , Kopec Wojciech 
Published: July 2024

Abstract
Potassium (K+) channels combine high conductance with high ion selectivity. To explain this efficiency, two molecular mechanisms have been proposed. The “direct knock-on” mechanism is defined by water-free K+ permeation and formation of direct ion–ion contacts in the highly conserved selectivity filter (SF). The “soft knock-on” mechanism involves co-permeation of water and separation of K+ by water molecules. With the aim to distinguish between these mechanisms, crystal structures of the KcsA channel with mutations in two SF residues—G77 and T75—were published, where the arrangements of K+ ions and water display canonical soft knock-on configurations. These data were interpreted as evidence of the soft knock-on mechanism in wild-type channels. Here, we test this interpretation using molecular dynamics simulations of KcsA and its mutants. We show that while a strictly water-free direct knock-on permeation is observed in the wild type, conformational changes induced by these mutations lead to distinct ion permeation mechanisms, characterized by co-permeation of K+ and water. These mechanisms are characterized by reduced conductance and impaired potassium selectivity, supporting the importance of full dehydration of potassium ions for the hallmark high conductance and selectivity of K+ channels. In general, we present a case where mutations introduced at the critical points of the permeation pathway in an ion channel drastically change its permeation mechanism in a nonintuitive manner.
Extreme Values of Dirichlet L-Functions At Critical Points of the Zeta Function
Authors: Chorge Shashank 
Published: July 2024

Abstract
We estimate large and small values of $|L(\rho^{\prime},\chi)|$, where χ is a primitive character mod q for q &gt; 2 and $\rho^{\prime}$ runs over critical points of the Riemann zeta function in the right half of the one-line and on the one-line, that is, the points where $\zeta^{\prime}(\rho^{\prime})=0$ and $1\leq\Re \rho^{\prime}$.
The strange career of Millian methods in comparative social science
Authors: Kurzman Charles 
Published: July 2024

Abstract
For half a century, comparative social science has been closely associated with John Stuart Mill’s methods of comparison. However, few social scientists had heard of Mill’s methods in 1970. Within a decade, the methods of agreement and difference had become part of the methodological canon—despite Mill’s objections that these methods should under no circumstances be used in the social sciences. Comparativists continued to overlook the methods that Mill actually proposed for the social sciences, which relied on an analogy with astronomical observations rather than chemistry experiments. Yet Mill’s own empirical research offered substantive findings without dwelling much on methods. Over the past half-century, successful works of comparative social science have pursued all three versions of Millian methods: the comparative methods that he widely associated with; the alternative methods that he proposed for social science; and the actual methods that he pursued, whose success lay in their creativity, not in methodological recipes.
Oxidative stress mediates nucleocytoplasmic shuttling of KPNA2 via AKT1‐CDK1 axis‐regulated S62 phosphorylation
Authors: Huang Jie‐Xin , Wang Chun‐I , Kuo Chia‐Yu , Chang Ting‐Wei , Liu Yu‐Chin , Hsiao Ting‐Feng , Wang Chih‐Liang , Yu Chia‐Jung 
Published: July 2024

AbstractKaryopherin α 2 (KPNA2, importin α1), a transport factor shuttling between the nuclear and cytoplasmic compartments, is involved in the nuclear import of proteins and participates in cellular processes such as cell cycle regulation, apoptosis, and transcriptional regulation. However, it is still unclear which signaling regulates the nucleocytoplasmic distribution of KPNA2 in response to cellular stress. In this study, we report that oxidative stress increases nuclear retention of KPNA2 through alpha serine/threonine‐protein kinase (AKT1)‐mediated reduction of serine 62 (S62) phosphorylation. We first found that AKT1 activation was required for H2O2‐induced nuclear accumulation of KPNA2. Immunoprecipitation and quantitative proteomic analysis revealed that the phosphorylation of KPNA2 at S62 was decreased under H2O2‐induced oxidative stress. We showed that cyclin‐dependent kinase 1 (CDK1), a kinase responsible for KPNA2 S62 phosphorylation, contributes to the localization of KPNA2 in the cytoplasm. AKT1 knockdown increased KPNA2 S62 phosphorylation and inhibited CDK1 activation. Furthermore, H2O2‐induced AKT1 activation promoted nuclear KPNA2 interaction with nucleophosmin 1 (NPM1), resulting in attenuation of NPM1‐mediated cyclin D1 gene transcription. Thus, we infer that the AKT1‐CDK1 axis regulates the nucleocytoplasmic shuttling and function of KPNA2 through spatiotemporal regulation of KPNA2 S62 phosphorylation under oxidative stress conditions.
The molecular biology of NF2/Merlin on tumorigenesis and development
Authors: Vlashi Rexhina , Sun Fuju , Zheng Chenggong , Zhang Xingen , Liu Jie , Chen Guiqian 
Published: July 2024

AbstractThe neurofibromatosis type 2 (NF2) gene, known for encoding the tumor suppressor protein Merlin, is central to the study of tumorigenesis and associated cellular processes. This review comprehensively examines the multifaceted role of NF2/Merlin, detailing its structural characteristics, functional diversity, and involvement in various signaling pathways such as Wnt/β‐catenin, Hippo, TGF‐β, RTKs, mTOR, Notch, and Hedgehog. These pathways are crucial for cellular growth, proliferation, and differentiation. NF2 mutations are specifically linked to the development of schwannomas, meningiomas, and ependymomas, although the precise mechanisms of tumor formation in these specific cell types remain unclear. Additionally, the review explores Merlin's role in embryogenesis, highlighting the severe developmental defects and embryonic lethality caused by NF2 deficiency. The potential therapeutic strategies targeting these genetic aberrations are also discussed, emphasizing inhibitors of mTOR, HDAC, and VEGF as promising avenues for treatment. This synthesis of current knowledge underscores the necessity for ongoing research to elucidate the detailed mechanisms of NF2/Merlin and develop effective therapeutic strategies, ultimately aiming to improve the prognosis and quality of life for individuals with NF2 mutations.
A20 in hepatic stellate cells suppresses chronic hepatitis by inhibiting DCLK1–JNK pathway‐dependent chemokines
Authors: Watakabe Keiya , Miyoshi Masato , Kakinuma Sei , Sato Ayako , Tsuchiya Jun , Shimizu Taro , Mochida Tomohiro , Inada Kento , Kaneko Shun , Kawai‐Kitahata Fukiko , Murakawa Miyako , Nitta Sayuri , Nakagawa Mina , Oshima Shigeru , Watanabe Mamoru , Ma Averil , Asahina Yasuhiro , Okamoto Ryuichi 
Published: July 2024

AbstractHepatic stellate cells (HSCs) are responsible for liver fibrosis accompanied by its activation into myofibroblasts and the abundant production of extracellular matrix. However, the HSC contribution to progression of liver inflammation has been less known. We aimed to elucidate the mechanism in HSCs underlying the inflammatory response and the function of tumor necrosis factor α‐related protein A20 (TNFAIP3). We established A20 conditional knockout (KO) mice crossing Twist2‐Cre and A20 floxed mice. Using these mice, the effect of A20 was analyzed in mouse liver and HSCs. The human HSC line LX‐2 was also used to examine the role and underlying molecular mechanism of A20. In this KO model, A20 was deficient in >80% of HSCs. Spontaneous inflammation with mild fibrosis was found in the liver of the mouse model without any exogenous agents, suggesting that A20 in HSCs suppresses chronic hepatitis. Comprehensive RNA sequence analysis revealed that A20‐deficient HSCs exhibited an inflammatory phenotype and abnormally expressed chemokines. A20 suppressed JNK pathway activation in HSCs. Loss of A20 function in LX‐2 cells also induced excessive chemokine expression, mimicking A20‐deficient HSCs. A20 overexpression suppressed chemokine expression in LX‐2. In addition, we identified DCLK1 in the genes regulated by A20. DCLK1 activated the JNK pathway and upregulates chemokine expression. DCLK1 inhibition significantly decreased chemokine induction by A20‐silencing, suggesting that A20 controlled chemokine expression in HSCs via the DCLK1–JNK pathway. In conclusion, A20 suppresses chemokine induction dependent on the DCLK1–JNK signaling pathway. These findings demonstrate the therapeutic potential of A20 and the DCLK1–JNK pathway for the regulation of inflammation in chronic hepatitis.
LncRNA SNHG12 suppresses adipocyte inflammation and insulin resistance by regulating the HDAC9/Nrf2 axis
Authors: Huang Xiaoyan , Chen Jixiong , Li Haidan , Cai Yuhua , Liu Li , Dong Qi , Li Yan , Ren Yi , Xiang Wei , He Xiaojie 
Published: July 2024

AbstractObesity is often associated with low‐grade inflammation. The incidence of obesity has increased annually worldwide, which seriously affects human health. A previous study indicated that long noncoding RNA SNHG12 was downregulated in obesity. Nevertheless, the role of SNHG12 in obesity remains to be elucidated. In this study, qRT‐PCR, western blot, and ELISA were utilized to examine the gene and protein expression. Flow cytometry was employed to investigate the M2 macrophage markers. RNA pull‐down assay and RIP were utilized to confirm the interactions of SNHG12, hnRNPA1, and HDAC9. Eventually, a high‐fat diet‐fed mouse model was established for in vivo studies. SNHG12 overexpression suppressed adipocyte inflammation and insulin resistance and promoted M2 polarization of macrophages that was caused by TNF‐α treatment. SNHG12 interacted with hnRNPA1 to downregulate HDAC9 expression, which activated the Nrf2 signaling pathway. HDAC9 overexpression reversed the effect of SNHG12 overexpression on inflammatory response, insulin resistance, and M2 phenotype polarization. Overexpression of SNHG12 improved high‐fat diet‐fed mouse tissue inflammation. This study revealed the protective effect of SNHG12 against adipocyte inflammation and insulin resistance. This result further provides a new therapeutic target for preventing inflammation and insulin resistance in obesity.
Body‐wide genetic deficiency of poly(ADP‐ribose) polymerase 14 sensitizes mice to colitis
Authors: Vedantham Madhukar , Polari Lauri , Poosakkannu Anbu , Pinto Rita G. , Sakari Moona , Laine Jukka , Sipilä Petra , Määttä Jorma , Gerke Heidi , Rissanen Tiia , Rantakari Pia , Toivola Diana M. , Pulliainen Arto T. 
Published: July 2024

AbstractInflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract affecting millions of people. Here, we investigated the expression and functions of poly(ADP‐ribose) polymerase 14 (Parp14), an important regulatory protein in immune cells, with an IBD patient cohort as well as two mouse colitis models, that is, IBD‐mimicking oral dextran sulfate sodium (DSS) exposure and oral Salmonella infection. Parp14 was expressed in the human colon by cells in the lamina propria, but, in particular, by the epithelial cells with a granular staining pattern in the cytosol. The same expression pattern was evidenced in both mouse models. Parp14‐deficiency caused increased rectal bleeding as well as stronger epithelial erosion, Goblet cell loss, and immune cell infiltration in DSS‐exposed mice. The absence of Parp14 did not affect the mouse colon bacterial microbiota. Also, the colon leukocyte populations of Parp14‐deficient mice were normal. In contrast, bulk tissue RNA‐Seq demonstrated that the colon transcriptomes of Parp14‐deficient mice were dominated by abnormalities in inflammation and infection responses both prior and after the DSS exposure. Overall, the data indicate that Parp14 has an important role in the maintenance of colon epithelial barrier integrity. The prognostic and predictive biomarker potential of Parp14 in IBD merits further investigation.