bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upregulated bone morphogenetic protein 8A (BMP8A) in triple negative breast cancer (TNBC) and its involvement in the bone metastasis
Authors: Sui Laijian , Cong Yizi , Liu Ming , Liu Xiangyi , Xu Yali , Jiang Wen G. , Ye Lin 
Published: July 2024

ObjectiveThe present study aimed to investigate the involvement of aberrant BMP8A expression in TNBC and bone metastasis.MethodsAberrant expression of BMP8A in breast cancer was first determined by analyzing The Cancer Genome Atlas breast cancer cohort (TCGA-BRCA) and an immunohistochemical (IHC) staining of BMP8A in a breast cancer tissue microarray (TMA). Clinical relevance of deregulated BMP8A in breast cancer was assessed using Kaplan-Meier online analysis. The influence of BMP8A on cellular functions of two TNBC cell lines was assessed using in vitro assays. Conditional medium (CM) collected from the supernatant of hFOB cells and bone matrix extract (BME) was applied to mimic the bone micro-environment to evaluate the role played by BMP8A in bone metastasis. Correlations with both osteolytic and osteoblastic markers were evaluated in the TCGA-BRCA cohort. Expression of certain responsive genes was quantified in the BMP8A overexpression cell lines. Additionally, signal transduction through both Smad-dependent and independent pathways was evaluated using Western blot assay.ResultsCompared to the adjacent normal tissues, BMP8A expression was significantly increased in primary tumors (p &lt; 0.05) which was associated with shorter distant metastasis free survival (DMFS) in TNBC (p &lt; 0.05). BMP8A was observed to enhance cell invasion and migration within TNBC cells. In the simulated bone milieu, both MDA-MB-231BMP8Aexp and BT549BMP8Aexp cells presented enhanced invasiveness. BMP8A level was strongly correlated with most osteolytic and osteoblastic markers, suggesting the potential involvement of BMP8A in bone metastasis in TNBC. Receptor activator of nuclear factor kappa-B ligand (RANKL) expression was significantly increased in BMP8A overexpressed triple-negative cell lines (MDA-MB-231 and BT549). Furthermore, enhanced phosphorylation of Smad3 and increased expression of epidermal growth factor receptor (EGFR) were observed in MDA-MB-231 cells overexpressing BMP8A.ConclusionBMP8A was upregulated in TNBC which was associated with poorer DMFS. BMP8A overexpression enhanced the invasion and migration of TNBC cells. With a putative role in osteolytic bone metastasis in TNBC, BMP8A represents a promising candidate for further investigation into its therapeutic potential.
Research on spatial patterns of soil erosion in wind erosion region based on the revised wind erosion equation and partial least squares regression
Authors: Huang Xu-Dong , Li Yue-Jia , Han Pei-Pei , Zheng Ran , Yan Hua-Jie , Zhao Pan-Pan , Zhang Xiao-Li , Feng Li-Li , Wang Dong , Zeng Feng-Juan 
Published: July 2024

Understanding the complex influencing factors of soil erosion is critical for maintaining regional ecological security. The revised wind erosion equation (RWEQ) and partial least squares regression (PLSR) model were used to reveal the primary factors affecting soil erosion. Based on the results of the RWEQ model, the wind erosion area was 8,439.3 km2 in 2018, accounting for 54.3% of the total planning area, and mild erosion, moderate erosion, intense erosion, very intense erosion, and fierce erosion accounted for 18.22%, 11.43%, 11.78%, 10.16%, and 2.74% of the total planning area, respectively. Based on the results of the PLSR model, the results indicate that the proportion of mining land, meteorological indicators, and mean square deviation of slope difference were positively correlated with the soil erosion area, intensity, and severity, respectively. The proportion of grassland and forest land was negatively correlated with the soil erosion area, intensity, and severity. The mean square deviation of slope difference, the mean square deviation of difference in elevation, and the proportion of urban land use contributed the most to the soil erosion severity index, with variable importance in projection (VIP) scores of 1.55, 1.44 and 1.43, respectively. The mean square deviation of slope difference, the proportion of urban land, and the mean square deviation of difference in elevation contributed the most to the soil erosion area, with VIP scores of 1.53, 1.26 and 1.24, respectively. The results provide new insights into wind erosion and the influences of weather conditions and human influences, which can guide regional soil and water conservation planning in wind erosion regions.
Impact of osteopenia and osteosarcopenia on the outcomes after surgery of hepatobiliary-pancreatic cancers
Authors: Wang Xiaofeng , Wu Min , Liu Qian , He Wei , Tian Yong , Zhang Yan , Li Cuiping , Liu Yanni , Yu Anqi , Jin Hongyan 
Published: July 2024

ObjectiveThe purpose of this study is to investigate potential associations between osteopenia, osteosarcopenia, and postoperative outcomes in patients with hepatobiliary-pancreatic cancer (HBPC).MethodsThree online databases, including Embase, PubMed, and the Cochrane Library, were thoroughly searched for literature describing the relationship between osteopenia, osteosarcopenia, and outcomes of surgical treatment of HBPC patients from the start of each database to September 29, 2023. The Newcastle-Ottawa Scale was used to rate the quality of the studies.ResultsThis analysis included a total of 16 articles with a combined patient cohort of 2,599 individuals. The results demonstrated that HBPC patients with osteopenia had significantly inferior OS (HR: 2.27, 95% CI: 1.70-3.03, p &lt; 0.001) and RFS (HR: 1.96, 95% CI: 1.42-2.71, p &lt; 0.001) compared to those without osteopenia. Subgroup analysis demonstrated that these findings were consistent across univariate and multivariate analyses, as well as hepatocellular carcinoma, biliary tract cancer, and pancreatic cancer. The risk of postoperative major complications was significantly higher in patients with osteopenia compared to those without osteopenia (OR: 1.66, 95% CI: 1.19-2.33, p &lt; 0.001). Besides, we also found that the presence of osteosarcopenia in HBPC patients was significantly related to poorer OS (HR: 3.31, 95% CI: 2.00-5.48, p &lt; 0.001) and PFS (HR: 2.50, 95% CI: 1.62-3.84, p &lt; 0.001) in comparison to those without osteosarcopenia.ConclusionPreoperative osteopenia and osteosarcopenia can predict poorer OS and RFS with HBPC after surgery.
Observational study on stability of within-day glycemic variability of type 2 diabetes inpatients treated with decoctions of traditional Chinese medicine
Authors: Xing Ying , Li Penghui , Pang Guoming , Zhao Hui , Wen Tiancai 
Published: July 2024

BackgroundWithin-day glycemic variability (GV), characterized by frequent and significant fluctuations in blood glucose levels, is a growing concern in hospitalized patients with type 2 diabetes mellitus (T2DM). It is associated with an increased risk of hypoglycemia and potentially higher long-term mortality rates. Robust clinical evidence is needed to determine whether traditional Chinese medicine (TCM) decoctions can be a beneficial addition to the management of within-day GV in this patient population.MethodsThis retrospective cohort study utilized data from adult inpatients diagnosed with T2DM admitted to the Traditional Chinese Medicine Hospital of Kaifeng. The primary outcome investigated was the association between the use of TCM decoctions and improved stability of within-day GV. Blood glucose variability was assessed using the standard deviation of blood glucose values (SDBG). For each patient, the total number of hospitalization days with SDBG below 2 mmol/L was calculated to represent within-day GV stability. Hospitalization duration served as the secondary outcome, compared between patients receiving TCM decoctions and those who did not. The primary analysis employed a multivariable logistic regression model, with propensity score matching to account for potential confounding variables.ResultsA total of 1,360 patients were included in the final analysis. The use of TCM decoctions was significantly associated with enhanced stability of within-day GV (OR = 1.77, 95% CI: 1.34–2.33, P &lt; 0.01). This association was most prominent in patients with a diagnosis of deficiency syndrome (predominantly qi-yin deficiency, accounting for 74.8% of cases) and a disease duration of less than 5 years (OR = 2.28, 95% CI: 1.21–4.29, P = 0.03). However, TCM decoctions did not exert a statistically significant effect on hospitalization duration among patients with T2DM (OR = 0.96, 95% CI: 0.91–1.01, P = 0.22).ConclusionThis study suggests that TCM decoctions may be effective in improving within-day GV stability in hospitalized patients with T2DM. This effect appears to be most pronounced in patients diagnosed with deficiency syndrome, particularly those with qi-yin deficiency and a shorter disease course. Further investigation is warranted to confirm these findings and elucidate the underlying mechanisms.
The dark side of mental toughness: a meta-analysis of the relationship between the dark triad traits and mental toughness
Authors: Liang Taihe , Wang Xianfei , Ng Sanfan , Xu Xuefeng , Ning Ziheng 
Published: July 2024

IntroductionThis meta-analysis investigates the relationships between the Dark Triad personality traits (narcissism, Machiavellianism, and psychopathy) and mental toughness. Previous research has shown mixed results regarding the influence of these traits on mental toughness. The objective of this meta-analysis is to synthesize existing literature and provide a comprehensive understanding of how Dark Triad traits correlate with mental toughness.MethodsA comprehensive literature search was conducted in 7 databases, Data were extracted by correlation and analyzed using a random-effects model.ResultsThe results yielding 27 effect sizes with a total of 12,378 participants, revealed a significant moderate positive association between narcissism and mental toughness (r = 0.327, p &lt; 0.001), suggesting that individuals with higher levels of narcissism tend to exhibit greater mental toughness. However, no significant associations were found between Machiavellianism (r = 0.023, p = 0.719) or psychopathy (r = −0.022, p = 0.625) and mental toughness.DiscussionThe findings contribute to a more nuanced understanding of the Dark Triad traits and their differential associations with adaptive psychological constructs, highlighting the unique role of narcissism in mental toughness. This meta-analysis provides valuable insights for future research and practical applications in fostering adaptive aspects of narcissism while mitigating its potential maladaptive consequences.
Differences in eating habits, physical activity, and sleep patterns among high school students and their parents before and during COVID-19 pandemic
Authors: Alashmali Shoug 
Published: July 2024

IntroductionThe recent COVID-19 pandemic has profoundly disrupted the eating and lifestyle habits among populations, especially among younger populations who are more prone to unhealthy dietary behaviours. However, current knowledge related to eating and lifestyle patterns, especially physical activity and sleep among different generations is limited. Our study sought to understand the eating habits, physical activity, and sleep behaviours among high school students compared to their parents in Saudi Arabia, before and during the COVID-19 pandemic.MethodsThis study was conducted in public high schools in Jeddah, Saudi Arabia (n = 8 schools), spanning from September 2021 to April 2022. Data were collected using an online questionnaire, distributed to all students and their parents (n = 516) in these schools.ResultsDuring the pandemic, parents (46.4%) showed a heightened interest in health and nutrition compared to students (32.7%, p = 0.001). Food preferences changed for 58.1% of participants; 70.0% of parents and 36.7% of students opted for homemade food (p &lt; 0.001). Unhealthy behaviours like eating out were more common in students. Weight varied by 74.0% during COVID-19, with more parents (41.4%) gaining weight than students (31.6%, p = 0.018). Physical activity dropped more for parents (42.1%) than students (23.9%), though 30.7 and 31.6% reported increases, respectively (p &lt; 0.001). Regardless of the pandemic, students were more likely to sleep later compared to parents (58.0% vs. 41.4%; p &lt; 0.001), while parents were more prone to waking up earlier compared to students (81.4% vs. 67.3%, p = 0.002).DiscussionThe findings underscore the varied pandemic impact on eating habits and physical activity between students and parents. Tailored interventions are vital for promoting healthier choices during health crises.
Uptake of protective tetanus toxoid vaccine doses and maternal associated factors during pregnancy in armed conflict zone, hospital-based cross-sectional study
Authors: Kebede Bizuneh Fassikaw , Muhidin Mustofa Semira 
Published: July 2024

BackgroundVaccinating pregnant women with tetanus toxoid (TT) is crucial to prevent neonatal tetanus, reducing related deaths by 94%. In conflict zones with restricted access to deliveries, neonates face a fatality rate of 80%–100%. This study explores the uptake of protective TT vaccine doses and maternal associated factors during pregnancy in an armed conflict zone.MethodsA hospital-based, descriptive, cross-sectional study was conducted of 357 pregnant women at delivery using simple random sampling. Data were collected through interviews with a structured questionnaire, and entered using Epi-data version 3.1, and exported using SPSS version 22 for further analysis. Binary and multivariable logistic regression analyses were used to identify significant variables for receiving protective TT doses during pregnancy at P &lt; 0.05.ResultIn this study, 355 pregnant women were included, with response rate of 99.4%. The mean age of the participants was 27.65 ± 6.23 years. During the study period, 67.3% of pregnant women received a protective TT vaccine dose while 33.3% were missed due to escalated armed conflict. The dropout rates were significant from TT5 to TT2 (17.6%), TT5 to TT3 (11.9%), and TT5 to TT4 (6.1%). However, maternal associated factors for the uptake of the TT protective vaccine dose were identified, including being aged 36–49 years [adjusted odds ratio (AOR) = 3.7; 95% confidence interval (CI) 1.54–7.8; P = 0.001], completing high school (AOR = 3.05; 95% CI 1.5–8.9; P = 0.02), having an antenatal care follow-up (AOR = 9.4; 95% CI 2.9–24.3; P = 0.001), previous media exposure (AOR = 15.5; 95% CI 7.5–25.3; P = 0.001), and good maternal knowledge (AOR = 2.7; 95% CI 1.8–4.9; P = 0.02).ConclusionThe uptake of the protective TT vaccine dose among pregnant women in a continued armed conflict area was low compared with previous study findings. Efforts should be made to increase vaccine uptake and reduce dropout rates by addressing both community and individual-level factors.
Forecasting changes in oral hygiene levels using the API index with different orthodontic appliances
Authors: Fedorova K. V. , Gavrilova O. A. , Zatevalov A. M. 
Published: July 2024

Relevance. The prevalence of various types of orthodontic pathology among the Russian population is quite high. Depending on the region, malocclusion are registered in 30.9% to 76.5% of cases. The high prevalence of orthodontic pathology and the unresolved issues related to both the pathology itself and the presence of concomitant diseases indicate the necessity for personalized methods of prevention and treatment of malocclusion during both the primary and mixed dentitions, which in 70-84% of cases are treated using both removable and fixed orthodontic appliances.Materials and methods. An observational study was conducted to identify factors contributing to the increased intensity of caries among children aged 6 to 11 with orthodontic pathology. The study evaluated the characteristics of hygiene knowledge and skills, as well as the Approximal Plaque Index (API), in children using various orthodontic appliances. To assess hygiene knowledge levels, a survey was administered to two groups of children aged 6-11: those undergoing orthodontic treatment and those who visited the dental clinic for a routine check-up and were diagnosed with orthodontic pathology. The questionnaire included questions about the primary and supplementary tools and practices for daily oral hygiene, the frequency of hygiene activities, and the patients' awareness of the importance of professional oral hygiene.Results. Factors that statistically significantly influence the level of hygiene and the Approximal Plaque Index (API) were identified. A computer program was developed to forecast the dynamics of oral hygiene levels (based on the API index) when using different orthodontic appliances. An algorithm for predicting changes in the API hygiene index was created, considering the use of orthodontic appliances, oral status, adherence to hygiene procedures, presence of harmful habits, and dietary behaviors. Negative factors significantly impacting hygiene levels include bruxism and daily consumption of sweets, while positive factors include adherence to the recommended frequency and duration of tooth brushing (at least twice a day) and the use of a medium-hard toothbrush when permanent teeth are erupting. During orthodontic treatment, additional negative factors impacting hygiene status include gingival bleeding (gingivitis), lack of lip closure, and harmful habits. The study of changes in hygiene levels over one year of treatment with various orthodontic appliances (braces, Haas appliance, SPA) showed that the fixed Haas appliance for treating dental and maxillofacial anomalies is the most favorable orthodontic design for mixed dentition.Conclusion. Factors significantly affecting the level of oral hygiene have been identified. The dynamics of the API hygiene index with various orthodontic appliances have been established. The most favorable appliance for mixed dentition is the HAAS appliance for rapid palatal expansion.
GPs' use of video and telephone consultation - implications for physical activity promotion for older adults
Authors: Callaghan Christopher Thomas , Cunningham Conor , O'Sullivan Roger 
Published: July 2024

The COVID-19 pandemic led general practitioners (GPs) to adopt video and telephone consultation (VC/TC) as part of routine practice. The potential impact on physical activity (PA) promotion and prescription for older adults, in routine practice, was unknown.AimTo understand how VC/TC have impacted on the routine promotion of PA to older adults in GPs consultations.Design & SettingA mixed method, cross-sectional study of GPs practice was conducted in Ireland and Northern Ireland in 2020.MethodAn online survey and interviews with GPs, explored awareness of PA guidelines, PA promotion during consultations to older adults (65+ years) and the impact on routine practice of moving to VC/TC during the pandemic.ResultsGPs from across the Island of Ireland agreed that PA promotion is part of routine practice. Analysis of interviews with GPs highlighted a need to develop practitioners’ knowledge of the guidelines and themes emerged around the use of VC/TC In routine practice. Positive themes highlighted that VC/TC enabled GPs to consult with a greater number of patients, thus prioritising face-to-face (FTFCs) consultations where needed. Barriers to using VC/TC included decreased visual assessments of patients FTF.ConclusionGPs are continuing to use VC/TC at the initial consultation stage, however the broader and longer-term implications on PA promotion with older adults are unknown.
Model Kepercayaan Kesehatan Pasien Diabetes Melitus Tipe II
Authors: Widhiastuti Ni Made Ayu , Candra I Wayan 
Published: July 2024

Diabetes mellitus type II is one of the health problems for the community both globally, regionally, and nationally. Most patients with type II diabetes mellitus have poor illness perception (everyone's belief about their disease and how to respond to disease). The purpose of this study was to determine the health belief model in type II diabetes mellitus patients at the Mangusada Hospital. This type of research was descriptive with a case study design using a cross-sectional approach. The sample in this study was 31 people, with apurposive sampling technique. The data analysis technique was carried out descriptively. The results of the study according to the characteristics of research subjects based on age who mostly had a good health belief model were found at the age of 41-60 years as many as 19 people (100,0 %). Based on gender, 13 people (68,4%) were found to have a good health belief model, from the highest level of education, 13 people (68,4%) were found to have a good health belief model in secondary education. Based on the most occupations found to have a good health belief model as self-employed as many as 7 people (36,8%), from the longest duration of illness found to have a good health belief model of more than 6 months chronic as many as 19 people (61,3%). The results of the study from 31 research subjects who mostly had a good health belief model were 19 people (61,3 %). It can be concluded that most of the research subjects with type II diabetes mellitus have a good health belief model.
Risk Factors for the Formation of Post-Traumatic Stress Disorder in Combat Participants
Authors: Двинских М.В. , Ичитовкина Е.Г. , Соловьев А.Г. , Коваль Н.А. , Жернов С.В. 
Published: July 2024

С целью выявления факторов риска формирования посттравматического стрессового расстройства у участников боевых действий обследовано 139 мужчин – сотрудников МВД России и МЧС России через пять дней после исполнения служебных задач в особых условиях. Проведены клиническое психопатологическое обследование, психологическое тестирование и химико-токсикологические исследования для выявления метаболитов психоактивных веществ. Показано, что ФР формирования ПТСР у участников боевых действий является наличие «субклинического тревожно- депрессивного состояния со снижением контроля поведения», «депрессивно-изоляционный» и «тревожно-дискоммуникативный» тип реагирования на стресс, частое употребление алкоголя для снятия стресса. Предложено рассмотреть возможность совершенствования психопрофилактических мероприятий с учетом выявленных факторов, способствующих формированию ПТСР.
In order to identify risk factors for the formation of post-traumatic stress disorder in combatants, 139 men were examined as part of a psychoprophylactic examination after performing official tasks in special conditions. A clinical psychopathological examination, psychological testing and chemical and toxicological studies were carried out to identify metabolites of psychoactive substances in the biological fluid. It has been shown that risk factors for the development of post-traumatic stress disorder in combatants are the presence of a "subclinical anxiety-depressive state with decreased behavioral control," "depressive-isolating" and "anxious-discommunicative" type of response to stress, frequent use of alcohol to relieve stress. It is proposed to consider the possibility of improving psychoprophylacticmeasures, taking into account the identified factors contributing to the formation of post-traumatic stress disorder.
Effective development of the organization in the concept of its life cycle
Authors: Шилова Н.Н. , Дружинина Ю.В. 
Published: July 2024

В данной статье рассмотрен сложный механизм эффективного управления бизне сом в современных условиях, в зависимости от стадии жизненного цикла, на котором находится орга низация. Проанализированы различные подходы к структуре жизненного цикла в контексте репутации компании.
This article considers the complex mechanism of effective business management in modern conditions, depending on the stage of the life cycle in which the organization is located. Various approaches to the structure of the life cycle are analyzed in the context of the company's reputation.