bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent efficacy and safety analysis of neoadjuvant therapy with Tislelizumab combined with Apatinib and chemotherapy in Borrmann type IV, large Borrmann type III, and Bulky N locally advanced gastric cancer(3-B).
Authors: Wei Shenghong , Ye Zaisheng , Wei Cheng , Wang Yi , Zeng Yi , Chen Jinhu , Liu Guoquan , Chi Yuanlong , Lin Qisheng , Wang Jingwei , Liu Sheng , Chen Shu , Jiang Jianping , Wang Xiaopeng , Chen Xiaoling , Chen Xiaoqi , Chen Luchuan 
Published: July 2024

Abstract

Background
To explore the efficacy and safety of immune checkpoint inhibitor Tislelizumab combined with Apatinib and chemotherapy in the neoadjuvant therapy of Borrmann IV, large Borrmann III and Bulky N locally advanced gastric cancer.
Methods
Patients with untreated, Her-2-negative, resectable locally advanced gastric adenocarcinoma (Borrmann IV, large Borrmann III, and Bulky N) were enrolled. Preoperative neoadjuvant therapy with tirelizumab combined with apatinib and SOX regimen was performed for 3 to 6 cycles. 3 cycles of evaluation, if PR, surgery; if SD, continue neoadjuvant therapy, after 6 cycles of re-evaluation of surgery.
Results
Forty patients were recruited, large Borrmann III in 26 cases, Borrmann IV in 6 cases, and Bulky N in 8 cases. The results of the radiographic evaluation were as follows: PR in 36 cases (90%), SD in 3 cases, PD in 1 case, and ORR rate was 90%. All patients underwent D2 or D2 + surgery, including R0 resection in 37 cases and R2 resection in 2 cases. Pathological effects: ypCR (TRG0) in 7 cases (17.9%), TRG1 in 9 cases, TRG2 in 18 cases, TRG3 in 5 cases. The MPR rate was 40.0%. Grade 3 to 4 adverse reactions occurred in 19 patients (47.5%) during neoadjuvant therapy. The incidence of postoperative complications was 33.3%, and grade IIIA or above was 7.7%, no perioperative death occurred.
Conclusion
For Borrmann IV, large Borrmann III, and Bulky N-positive, locally advanced gastric cancer, the triple regimen of Tislelizumab combined with Apatinib and chemotherapy can achieve clinical benefit with acceptable safety.
Clinical Trial Registration:
Registered with ClinicalTrials.gov, registration number NCT05223088.
Harnessing the Collective Potential of Lanthanide Single-Atom Catalysts for Efficient CO2-to-CO Electroreduction
Authors: Liu Min , Wang qiyou , Luo Tao , Cao Xueying , Gong Yujie , Liu Yuxiang , Li Hongmei , Lu Ying Rui , Chan Ting-Shan , Ma Chao , Liu Kang , Fu Junwei , Zhang Shiguo , Liu Changxu , Zhang Lin , Liyuan Chai 
Published: July 2024

Abstract

Single-atom catalysts (SACs) have received increasing attention due to their 100% atomic utilization efficiency. The electrochemical CO2 reduction reaction (CO2RR) to CO using SAC offers a promising approach for CO2 utilization, but achieving facile CO2 adsorption and CO desorption remains challenging for traditional SACs. Instead of singling out specific atoms, we propose a novel strategy utilizing atoms from the entire lanthanide (Ln) group to facilitate the CO2RR. Density functional theory calculations, operando spectroscopy, and X-ray absorption spectroscopy elucidate the bridging adsorption mechanism for a representative erbium (Er) single-atom catalyst. Remarkably, we realize a series of Ln SACs spanning 14 elements that exhibit CO Faradaic efficiencies exceeding 90%. The Er catalyst achieves an ultrahigh turnover frequency of ~ 130,000 h‒1, accompanying with a remarkable 42.6% full-cell energy efficiency and record-high 94% single-pass CO2 conversion efficiency. This unparalleled catalytic platform leverages the collective potential of the lanthanide group, introducing new possibilities for efficient CO2-to-CO conversion and beyond through the exploration of unique bonding motifs in single-atom catalysts.
Environmental factors in the development of Coronary Artery Atherosclerosis
Authors: Siddiqui Ifrah , Ahmad Fatima , Khan Nabeel Ahmad , Naeem Almas , Kumar Mahesh , Khalid Muhammad Usaid 
Published: July 2024

Abstract

Objective:
This study aims to comprehensively investigate the role of environmental factors—diet, physical activity, tobacco smoke, air pollution, psychosocial factors, occupational exposures, noise pollution, climate factors, urbanization, and socioeconomic status—in the pathogenesis of coronary artery disease (CAD).
Background:
Coronary artery disease (CAD) poses a significant global health challenge influenced by a complex interplay of environmental, behavioral, and socioeconomic factors. These factors contribute to inflammation, endothelial dysfunction, atherosclerosis, plaque rupture, and thrombosis, underscoring the need for a holistic understanding to inform effective preventive and therapeutic strategies.
Methods:
A systematic review was conducted across PubMed, MEDLINE, Google Scholar, and various journals to identify relevant studies on environmental factors and CAD. The search encompassed articles without date restrictions, adhering to PRISMA guidelines. Studies exploring causal links between environmental factors and CAD pathophysiology were included, with data synthesized to elucidate key mechanisms and relationships.
Results:
The investigation highlights complex connections between environmental factors and CAD pathophysiology. Diets high in saturated fats and sugars exacerbate inflammation and endothelial dysfunction, while diets rich in antioxidants and omega-3 fatty acids mitigate these effects. Physical activity enhances endothelial function and reduces inflammation markers, promoting plaque stability. Tobacco smoke and air pollution are linked to increased inflammation, endothelial dysfunction, and plaque instability. Psychosocial stressors, occupational exposures, noise pollution, climate variations, urbanization, and lower socioeconomic status similarly contribute to CAD progression through diverse mechanisms.
Conclusion:
This study underscores the multifaceted impact of diet, physical activity, tobacco smoke, air pollution, psychosocial factors, occupational exposures, noise pollution, climate factors, urbanization, and socioeconomic status on CAD pathogenesis. Understanding these causal links is critical for developing comprehensive strategies to mitigate CAD risk and improve cardiovascular outcomes globally. Integrated public health initiatives and targeted policy interventions addressing these factors are essential for effective CAD prevention and management.
Расчет и коррекция дозы цитостатических препаратов в режимах кондиционирования перед аллоТГСК у пациентов с избытком массы тела или ее дефицитом
Authors: Карпенко Елена Юрьевна , Дроков М. Ю. 
Published: July 2024

In Russia, like in the rest of the world, the number of overweight people has been growing for the last 20 years. According to different studies, obesity and overweight incidence among adults is 20.5–54.0 %. Obesity incidence increased from 10.8 % in 1993 to 27.9 % in 2017 in men and from 26.4 to 31,8 % in women, respectively. Pharmacokinetics of drugs including cytostatic agents, differs in obese vs. normal-weight patients. This is accounted for by renal/hepatic clearance changes as well as by increased distribution of lipophilic drugs with their enhanced protein-binding ability. All these factors create a challenge for a correct calculation of drug doses for obese patients. This issue becomes particularly acute when such patients undergo allogeneic hematopoietic stem cell transplantation with preconditioning regimens using sublethal drug doses. This paper attempts to review current approaches to drug dose calculation to be used in preconditioning regimens for over- and underweight patients.
PENGEMBANGAN PERANGKAT PEMBELAJARAN BERDIFERENSIASI SEBAGAI INISIATOR MERDEKA BELAJAR
Authors: Faqih Muhammad Izzatul , Adriyani Zuanita , Muna Khoriyatul 
Published: July 2024

AbstractThis research aims to (1) understand the development of differentiated learning tools as initiators of independent learning, (2) assess the feasibility of differentiated learning tools as initiators of independent learning, and (3) determine the effectiveness of learning using differentiated learning tools as initiators of independent learning. The research adopted the Research and Development (RD) methodology, employing data collection techniques such as documentation, observation, interviews, and questionnaires. The research yielded learning tools in the form of Syllabus (RPS), Lesson Implementation Plan (LKM), authentic evaluation instruments, and instruments for learning styles that are highly suitable according to experts. The effectiveness of the tools was evidenced by significantly high scores with a Sig (2-tailed) value less than 0.05. AbstrakPenelitian ini bertujuan untuk (1) Memahami cara mengembangkan perangkat pembelajaran berdiferensiasi sebagai inisiator merdeka belajar, (2) Mengetahui kelayakan perangkat pembelajaran berdiferensiasi sebagai inisiator merdeka belajar, (3) Mengetahui efektivitas pembelajaran menggunakan perangkat pembelajaran berdiferensiasi sebagai inisiator merdeka belajar. Jenis dari penelitian yang dipakai adalah penelitian Research and Developement (RD). Teknik pengumpulan data menggunakan dokumentasi, observasi, wawancara, dan angket. Hasil penelitian perangkat pembelajaran berupa RPS, LKM, instrumen evaluasi autentik, dan instrumen untuk gaya belajar yang sangat layak digunakan menurut ahli serta perangkat efektiv dengan nilai yang sangat signifikan ditandai dengan skor Sig (2-tailed) kurang dari 0,05.Kata kunci: Perangkat pembelajaran berdiferensiasi; merdeka belajar
Wavelet-based analysis of hydro-climatic and vegetation dynamics in heterogeneous agro-climatic zones of East Africa
Authors: Batungwanayo Pacifique , Vanclooster Marnik , Alonso Alice , Frendy Koropitan Alan 
Published: July 2024

ABSTRACT

Natural and human-induced factors profoundly affect agricultural crop production in East Africa, sparking ongoing debates about their relative significance. This study investigates the impact of localized hydro-climatic variables like precipitation, temperature, vapor pressure deficit, and water deficit on crop production. Additionally, it examines climate oscillations such as El Niño-Southern Oscillation (ENSO), Indian Ocean Dipole (IOD), North Atlantic Oscillation (NAO), and Pacific Decadal Oscillation (PDO). Employing the Normalized Difference Vegetation Index (NDVI) metric, analysis focuses on four climatic zones, ranging from arid to humid. Results suggest that the dominant periodicities for NDVI and hydro-climatic factors are annual (8-16 months) and intra-annual (4-8 months), while circulation indices exhibit inter-annual and inter-decadal periodicity. The study reveals that vegetation dynamics are more sensitive to annual and intra-annual fluctuations in hydro-climatic factors compared to inter-annual and inter-decadal oscillations in circulation indices. The bi-variate wavelet coherence (WTC) analysis reveals that precipitation and ENSO are the most significant factors explaining vegetation variability, while multiple wavelet coherence (MWC) analysis demonstrates that all variables contribute significantly to NDVI variability. This research underscores the importance of wavelet techniques in deciphering complex relationships between hydro-climatic factors and crop production, with implications for agricultural management and policy in East Africa.
Water environment collaborative governance policy in the Yangtze River Delta
Authors: Tian Yuanhong , Bao Cunkuan , Ruth Matthias 
Published: July 2024

ABSTRACT

Water environment collaborative governance is an important policy agenda during the Yangtze River Delta integration. Based on collaborative theory and policy value theory, this essay finds 144 water environment collaborative governance policies in the region from 2007 to 2022. It utilizes a policy collaborative model to discuss the water environment collaborative governance state at the regional and provincial levels in this region. Results show that 87.5% of water environment collaborative governance policies are enacted by local government in the region in this period, the main policy aims of which are water resource protection and wastewater pollution control. More policy attention will need to be paid to water environment restoration and off-office auditing of cadres. While administration policies and legal interventions are the main policy levers, economic policies and personal policies are relatively underused. Policy elements are significantly diversified at the provincial level in the region. In response to the findings above, this essay offers advice to improve water environment collaborative governance in the Yangtze River Delta region on four aspects: giving local governments full discretion in wastewater pollution treatment; giving full play of the water pollution control policies' value; adopting differentiated water pollution control policies; and strategies among the local government in the region, exerting policy stability.
Análisis de sustratos aceptados para la co-digestión anaeróbica en la PTAR de Straubing, Alemania
Authors: Berrio Uribe Juliana , Ossa Carrasquilla Laura Catalina 
Published: July 2024

La adopción de nuevas formas de producción energética es uno de los retos que enfrentan los países a nivel mundial debido al progresivo agotamiento de los combustibles fósiles. En ese sentido, la digestión conjunta de residuos orgánicos en Plantas de Tratamiento de Agua Residual (PTAR) ha ganado gran aceptación, pues ofrece una alternativa para usar diferentes tipos de biomasa para satisfacer necesidades energéticas y ayuda en la gestión de residuos y recuperación de nutrientes. Sin embargo, aceptar sustratos adicionales para la co-digestión, supone estudios fisicoquímicos minuciosos, puesto que sus características pueden influir tanto en la estabilidad del proceso como en la calidad y producción del biogás.
En concordancia con lo anterior, el presente trabajo implementó el método de estudio de caso a través del análisis descriptivo para evaluar los sustratos aceptados para la co-digestión anaeróbica en la PTAR de Straubing en Alemania (SER GmbH). Como resultado, se encontró que las grasas flotantes (C1) y la leche con inhibidores (C5) fueron los sustratos que presentaron mayor producción de biogás por unidad de masa tratada, 90 % por encima de los residuos de destilación y 70 % sobre los lodos crudos.
Estos hallazgos subrayan la importancia de seleccionar cuidadosamente los sustratos para la co-digestión en las PTAR, destacando la posibilidad de aprovechar recursos potenciales, como los evaluados en este estudio, para aumentar la eficiencia en la producción de biogás y, por lo tanto, promover una transición más efectiva hacia fuentes de energía sostenible en el contexto global.
La PTAR de Straubing en Alemania se convierte así en un ejemplo de las posibilidades que ofrece la co-digestión en la generación de energía sostenible y la gestión de residuos. La inclusión de grasas flotantes y leche con inhibidores como sustratos exitosos ilustra cómo la investigación y la implementación cuidadosa pueden optimizar el rendimiento de estas instalaciones.
Diseño de objeto virtual de aprendizaje (OVA) para el análisis de las leyes de conservación en colisión de hadrones.
Authors: Devia Roa David Mateo 
Published: July 2024

Para la formación disciplinar del estudiante de licenciatura en Física de la Universidad Distrital Francisco José de Caldas, es esencial la comprensión y análisis de los conceptos de colisión y desintegración de partículas relativistas y las leyes de conservación que los rigen, estas se encuentran inmersas dentro del área de física moderna y mecánica cuántica, asignaturas del núcleo obligatorio pertenecientes al plan de estudios de 7°y 8° semestre, los contenidos mencionados resultan desafiantes debido a su naturaleza abstracta y compleja, por ende emerge la necesidad de brindar herramientas que dinamicen y afiancen la interpretación, análisis y por consiguiente la fijación memorística de dichos conceptos, que con ayudas visuales e interactivas como los Objetos Virtuales de Aprendizaje . Los recursos educativos digitales, como los Objetos Virtuales de Aprendizaje, son diseñados para facilitar y mejorar el proceso de enseñanza y aprendizaje a través de herramientas tecnológicas interactivas, su uso pertinente y eficiente permite desarrollar conceptos básicos, competencias actitudinales, cognitivas y habilidades que despliegan el trabajo autónomo dentro de diferentes áreas de conocimiento. Proporcionan una mayor flexibilidad en la enseñanza y aprendizaje. Para esto, se diseña un objeto virtual de aprendizaje mediante el modelo instruccional ADDIE: (Análisis, Diseño, Desarrollo, Implementación y Evaluación) este, lleva un modelo constructivista que muestra las interacciones de colisiones y decaimiento entre partículas constituidas por las primeras generaciones de modelo estándar y que dan partida a las simetrías SU(3), los hadrones; tomando como punto de partida los experimentos de cámaras de burbujas como herramienta que ayuda a solventar dicha naturaleza abstracta, Este trabajo contempla las dos primeras etapas del modelo ADDIE.
Time to rethink 'watchdog' journalism in the Pacific
Authors: Seneviratne Kalinga 
Published: July 2024

For more than five decades, ‘Watchdog Journalism’ has been taught as the yardstick for a free media. With the so-called ‘mainstream’ media becoming increasingly commercialised—both in a global scale and domestically—and with the media being primarily owned by business conglomerates, the ‘watchdog’ model has created a journalism culture that is too adversarial and creates conflicts rather than helping to solve today’s problems/conflicts. A new paradigm of watchdog journalism is needed where the media is able to hold powerful players to account for facilitating the development/livelihood needs of communities, especially those in the margins of society. This new paradigm of journalism needs to focus on ‘development rights’ rather than ‘human rights’ taking into account many aspects of the United Nations’ Sustainable Development Goals (SDGs). The SDGs should be looked at in terms of a new definition of human rights where the journalist could play a similar role to that prescribed in ‘watchdog’ journalism theory, but looking for solutions rather conflicts, and include a larger field of stakeholders which need to be made accountable such as governments, big business and particularly conglomerates—even NGOs and faith-based organisations. This watchdog role needs to be applied to trade agreements and other treaties, including those addressing climate change. To develop a new journalism culture to address these issues, media training programmes in the Pacific need to rethink their strategies and examine how to promote independent social media models that are economically and sustainably viable.
VOICES OF RUDARI WOMEN FROM FILIAŞI (ROMANIA) IN THE CONTEXT OF CONVERSION TO PENTECOSTALISM
Authors: GIRIGAN Gabriel 
Published: July 2024

Voices of Rudari women from Filiaşi (Romania) in the Context of Conversion to Pentecostalism. The present article examines conversion to Pentecostalism among Rudari women in post-socialist Eastern Europe. The case study focuses on a Rudari ethnic community located in a small town in southern Romania and shows that Rudari women assume a dual role: one involves preserving the interplay between Pentecostalism and local culture, while the other entails initiating conversion among men. Women facilitate conversion through visions, dreams, or manifestations of illness, which position them as gatekeepers who translate Pentecostalism into the local cultural context. Furthermore, women serve as guides for men undergoing conversion, playing a vital role in bridging the gap between Rudari traditions and the Pentecostal culture. They demonstrate proficiency in interpreting Pentecostal ecstatic phenomena within their predominantly male community, with their voices serving as mediators throughout the conversion process (Brusco, 2010). Similarly, women act as “therapists,” facilitating men’s conversion and addressing issues related to the transformation of traditional notions of masculinity.
Voci ale femeilor rudărese din Filiași (România) în contextul convertirii la penticostalism. Articolul de față prezintă convertirea la penticostalism în rândul femeilor dintr-o comunitate de rudari în contextul postsocialismului est-european. Studiul de caz prezintă o comunitate etnică de rudari dintr-un oraș mic din sudul României. Argumentez că femeile rudărese au un dublu rol în comunitate, primul de conservare a dualismului dintre penticostalism și cultura locală și al doilea de inițiere a convertirii în rândul bărbaților. Femeile alimentează convertirea religioasă prin viziuni, vise sau semne de boală. Toate aceste condiții prealabile au facilitat devenirea lor ca interprete ale traducerii penticostalismului în cultura locală. Mai mult decât atât, femeile devin astfel călăuze ale convertirii bărbaților. Ele joacă, de asemenea, un rol important în medierea celor două lumi, tradițiile Rudari și noua cultură penticostală. Ele sunt capabile să descifreze semnele extatice penticostale într-un context comunitar dominat de bărbați, vocile femeilor devenind astfel un mediator în procesul de convertire (Brusco, 2010). În mod similar, femeile acționează ca „terapeute” în contextul procesului de convertire și transformare a machismului bărbaților.
Cuvinte-cheie: Penticostalism, România, studii asupra băieşilor/rudarilor, transformare culturală, naraţiuni ale convertirii, studii de gen, etnografie
Article history: Received 09 October 2023; Revised 14 May 2024; Accepted 19 May 2024; Available online 25 June 2024; Available print 30 June 2024.
Blockchain as a Facilitator For Secure Migration: A Case Study of E-Commerce in Indonesia
Authors: Arif Zainal , Zulfitria  , Bariyah Oneng Nurul , Sopa  , Supyadillah Asep , Darmansyah Dina Febriani 
Published: July 2024

Objective: The objective of this study is to investigate the role of blockchain technology as a facilitator for secure data migration in the Indonesian e-commerce sector, with the aim of Amidst the growing concerns over data security and privacy in online transactions, blockchain emerges as a potential solution due to its inherent characteristics of decentralization, transparency, and immutability.

Theoretical Framework: In this topic, the main concepts and theories that underpin the research are presented. this study delves into the multifaceted role of blockchain technology in e-commerce, particularly focusing on enhancing data security and fostering consumer trust, a critical concern in the digital marketplace.

Method: The methodology adopted for this research comprises a qualitative approach, utilizing case studies of Indonesian e-commerce platforms to examine how blockchain technology can enhance data security during migration processes. Through in-depth interviews and document analysis, the study explores the current challenges faced by e-commerce platforms in managing data security and how blockchain integration can address these issues.
The results obtained that blockchain technology not only strengthens data security but also fosters trust among users, which is crucial for the growth of e-commerce.

Results and Discussion: The practical and theoretical implications of this research are discussed, providing insights into how the results can be applied or influence practices in the field of The study also identifies the barriers to blockchain adoption, including technological complexity and regulatory uncertainties.

Originality/Value: This study contributes to the understanding of blockchain applications in e-commerce, particularly in the context of a developing country, and provides insights for businesses and policymakers in adopting blockchain for secure data management.