bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photo-, osmo- and phonophobia in the premonitory phase of migraine: mistaking symptoms for triggers?
Authors: Schulte Laura H , Jürgens Tim P , May Arne 
Published: February 2015

Abstract

Background
Certain environmental stimuli are frequently reported as typical triggers of migraine pain. Whether these so-called triggers are independent precipitators of migraine pain or mere symptoms of the premonitory phase of migraine remains to be elucidated.

Methods
In this retrospective cohort study of 1010 migraine patients of a tertiary headache center we assessed the frequency of common trigger factors, premonitory symptoms and accompanying symptoms as well as basic headache characteristics and demographic data.

Results
Premonitory symptoms with an onset of 2 or more hours prior to the headache were present in 38.9% of migraine patients, the most frequent being a tense neck, phonophobia and difficulty concentrating. There was a clear overlap of certain trigger factors and the presence of corresponding premonitory symptoms: flickering or bright light as a trigger was associated with higher frequency of photophobia in the premonitory phase. The same applied to the presence of food craving and osmophobia in the premonitory phase and certain foods or odours as trigger factors.

Conclusions
Our data thus support the view that commonly reported trigger factors of migraine are not so much independent precipitators of migraine pain, but that they are most likely just misinterpreted results of enhanced attention to certain stimuli mediated by typical premonitory symptoms of migraine pain.
Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management
Authors: van Schooneveld Eleni , Wildiers Hans , Vergote Ignace , Vermeulen Peter B , Dirix Luc Y , Van Laere Steven J 
Published: February 2015

AbstractMicroRNAs (miRNAs) are an emerging class of gene expression modulators with relevant roles in several biological processes, including cell differentiation, development, apoptosis, and regulation of the cell cycle. Deregulation of those tiny RNA molecules has been described frequently as a major determinant for the initiation and progression of diseases, including cancer. Not only miRNAs but also the enzymes responsible for miRNA processing could be deregulated in cancer. In this review, we address the role of miRNAs in the pathogenesis of breast cancer, since there are oncogenic, tumor-suppressive, and metastatic-influencing miRNAs. Additionally, the different detection platforms and normalization strategies for miRNAs will be discussed. The major part of this review, however, will focus on the capability of miRNAs to act as diagnostic, predictive, or prognostic biomarkers. We will give an overview of their potential to correlate with response to or benefit from a given treatment and we will consider their ability to give information on prognosis in breast cancer. We will focus on miRNAs validated by more than one study or verified in independent cohorts or where results rely on preclinical as well as clinical evidence. As such, we will discuss their potential use in the personalized management of breast cancer.
Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth
Authors: Ren Xiu-Rong , Wang Jiangbo , Osada Takuya , Mook Robert A , Morse Michael A , Barak Larry S , Lyerly Herbert Kim , Chen Wei 
Published: February 2015

Abstract
Introduction
Human epidermal growth factor receptor HER3 has been implicated in promoting the aggressiveness and metastatic potential of breast cancer. Upregulation of HER3 has been found to be a major mechanism underlying drug resistance to EGFR and HER2 tyrosine kinase inhibitors and to endocrine therapy in the treatment of breast cancer. Thus, agents that reduce HER3 expression at the plasma membrane may synergize with current therapies and offer a novel therapeutic strategy to improve treatment.

Methods
We devised an image-based screening platform using membrane localized HER3-YFP to identify small molecules that promote HER3 internalization and degradation. In vitro and in vivo tumor models were used to characterize the signaling effects of perhexiline, an anti-anginal drug, identified by the screening platform.

Results
We found perhexiline, an anti-anginal drug, selectively internalized HER3, decreased HER3 expression, and subsequently inhibited signaling downstream of HER3. Consistent with these results, perhexiline inhibited breast cancer cell proliferation in vitro and tumor growth in vivo.

Conclusions
This is the first demonstration that HER3 can be targeted with small molecules by eliminating it from the cell membrane. The novel approach used here led to the discovery that perhexiline ablates HER3 expression, and offers an opportunity to identify HER3 ablation modulators as innovative therapeutics to improve survival in breast cancer patients.
Transcriptome analysis of ageing in uninjured human Achilles tendon
Authors: Peffers Mandy Jayne , Fang Yongxiang , Cheung Kathleen , Wei Tim Koh Jia , Clegg Peter David , Birch Helen Lucy 
Published: February 2015

Abstract
Introduction
The risk of tendon injury and disease increases significantly with increasing age. The aim of the study was to characterise transcriptional changes in human Achilles tendon during the ageing process in order to identify molecular signatures that might contribute to age-related degeneration.

Methods
RNA for gene expression analysis using RNA-Seq and quantitative real-time polymerase chain reaction analysis was isolated from young and old macroscopically normal human Achilles tendon. RNA sequence libraries were prepared following ribosomal RNA depletion, and sequencing was undertaken by using the Illumina HiSeq 2000 platform. Expression levels among genes were compared by using fragments per kilobase of exon per million fragments mapped. Differentially expressed genes were defined by using Benjamini-Hochberg false discovery rate approach (P <0.05, expression ratios 1.4 log2 fold change). Alternative splicing of exon variants were also examined by using Cufflinks. The functional significance of genes that showed differential expression between young and old tendon was determined by using ingenuity pathway analysis.

Results
In total, the expression of 325 transcribed elements, including protein-coding transcripts and non-coding transcripts (small non-coding RNAs, pseudogenes, long non-coding RNAs and a single microRNA), was significantly different in old compared with young tendon (±1.4 log2 fold change, P <0.05). Of these, 191 were at higher levels in older tendon and 134 were at lower levels in older tendon. The top networks for genes differentially expressed with tendon age were from cellular function, cellular growth, and cellular cycling pathways. Notable differential transcriptome changes were also observed in alternative splicing patterns. Several of the top gene ontology terms identified in downregulated isoforms in old tendon related to collagen and post-translational modification of collagen.

Conclusions
This study demonstrates dynamic alterations in RNA with age at numerous genomic levels, indicating changes in the regulation of transcriptional networks. The results suggest that ageing is not primarily associated with loss of ability to synthesise matrix proteins and matrix-degrading enzymes. In addition, we have identified non-coding RNA genes and differentially expressed transcript isoforms of known matrix components with ageing which require further investigation.
Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis
Authors: Andersson Annica , Stubelius Alexandra , Karlsson Merja Nurkkala , Engdahl Cecilia , Erlandsson Malin , Grahnemo Louise , Lagerquist Marie K , Islander Ulrika 
Published: February 2015

Abstract
Introduction
The incidence and progression of many autoimmune diseases are sex-biased, which might be explained by the immunomodulating properties of endocrine hormones. Treatment with estradiol potently inhibits experimental autoimmune arthritis. Interleukin-17-producing T helper cells (Th17) are key players in several autoimmune diseases, particularly in rheumatoid arthritis. The aim of this study was to investigate the effects of estrogen on Th17 cells in experimental arthritis.

Methods
Ovariectomized DBA/1 mice treated with 17β-estradiol (E2) or placebo were subjected to collagen-induced arthritis (CIA), and arthritis development was assessed. Th17 cells in joints and lymph nodes were studied by flow cytometry. Lymph node Th17 cells were also examined in ovariectomized estrogen receptor α–knockout mice (ERα−/−) and wild-type littermates, treated with E2 or placebo and subjected to antigen-induced arthritis.

Results
E2-treated mice with established CIA showed reduced severity of arthritis and fewer Th17 cells in joints compared with controls. Interestingly, E2-treated mice displayed increased Th17 cells in lymph nodes during the early phase of the disease, dependent on ERα. E2 increased the expression of C-C chemokine receptor 6 (CCR6) on lymph node Th17 cells as well as the expression of the corresponding C-C chemokine ligand 20 (CCL20) within lymph nodes.

Conclusions
This is the first study in which the effects of E2 on Th17 cells have been characterized in experimental autoimmune arthritis. We report that E2 treatment results in an increase of Th17 cells in lymph nodes during the early phase of arthritis development, but leads to a decrease of Th17 in joints during established arthritis. Our data suggest that this may be caused by interference with the CCR6-CCL20 pathway, which is important for Th17 cell migration. This study contributes to the understanding of the role of estrogen in the development of autoimmune arthritis and opens up new fields for research concerning the sex bias in autoimmune disease.
Review of Alexandros Nafpliotis's Britain and the Greek Colonels: Accommodating the Junta in the Cold War
Authors: Skalidakis Yannis 
Published: February 2015

<p>Review of Alexandros Nafpliotis, <em>Britain and the Greek Colonels: Accommodating the Junta in the Cold War. </em>London: IB Tauris, 2013. 307 pp.</p>
A prospective outcome study of patients with profound combined immunodeficiency (P-CID)
Authors: Speckmann Carsten , Uhlmann Annette , Doerken Sam , Wolkewitz Martin , Pohl Annette , Ehl Stephan 
Published: February 2015

This is a prospective outcome study of patients with profound combined immunodeficiency (P-CID) (study number DRKS00000497). Combined immunodeficiencies (CID) are a heterogeneous group of inherited immune disorders with impaired T-cell development and (or) function manifesting through increased susceptibility to infections and (or) immune dysregulation. They can be delineated from severe CID (SCID) by their manifestation beyond the first year of life. Profound CID (P-CID) is a potentially life-threatening form of CID, in which stem cell transplant (SCT) is a relevant consideration at diagnosis. The primary objective of the study is to provide natural history data on patients with P-CID, irrespective of whether they undergo hematopoietic stem cell transplant (HSCT) or not. The goals are to determine survival, the frequency of severe events, and quality of life (QOL) 5 years after study inclusion. The secondary objective is to develop a risk model for P-CID patients. The model is developed from a set of clinical and laboratory parameters obtained at diagnosis, at study inclusion, and yearly thereafter. The tertiary objectives of this study are to determine the effects of donor, recipient, and treatment factors on the outcome of HSCT. The goal is to determine the quality of engraftment and immunological reconstitution and to determine the effects of these parameters on clinical outcome. The main hypothesis is that P-CID patients undergoing early HSCT have a better 5-year survival rate than patients who undergo late HSCT or are not transplanted. This is a prospective multi-centre international cohort study (observational study). Enrolled patients will be evaluated and treated according to local institutional protocols. They will receive comparable baseline and follow-up evaluations across all participating centres, irrespective of the therapeutic strategy at the individual site. There will be at least 6 study visits (scheduled yearly) for all patients. Because of the variable history prior to study inclusion, a morbidity score is determined for each patient at study visit 1. For those patients undergoing HSCT, an additional 6 month post-HSCT visit will be scheduled. The study visits will document immunological parameters, severe events including major infections, and major manifestations of immune dysregulation, severe transplant-related events, and QOL.
Inverse scattering problem for the nonstationary Dirac
equation on the half-plane
Authors: Ismailov Mansur I. 
Published: February 2015

Abstract
In this paper, the inverse scattering problem for the nonstationary Dirac
system on the half-plane is considered. The uniqueness criterion for the
inverse scattering problem in terms of boundary condition is described and
the restoration of the potential from the scattering operator is proved.
Intensity Analysis and Luminescence Spectra of Non-Aqueous Solutions of Europium Compounds
Authors: Legendziewicz Janina , Oczko Grażyna , Stręk Wiesław 
Published: February 2015

Abstract
The oscillator strengths of the f-f transitions as well the fluorescence spectra for europium Perchlorate, chloride and nitrate in mono- and disubstituted amides have been measured. The Judd-Ofelt parameters are calculated. The formation of inner-sphere europium complexes is discussed on the basis of intensity analysis of the absorption and luminescence spectra. In mono- and disubstituted amides solutions the f-f transitions of Eu+3 have been analysed and the three parameters fitted with satisfactory accuracy. Among all f-f transitions the hypersensitive ones in absorption 7 F0 → 5 D0 and fluorescence 5 D0 → 7 F2 varied most markedly. From an analysis of the data it was concluded that only Eu(NO3)3 and EUCl3 in DMF form inner-sphere complexes. At low concentration of EUCl3 in DMF the predominant form is [EuCl(DMF)y−1]+2 , whereas at high concentration the predominant form is [EUCl2(DMF)y−2]+1 . The intensity of the hypersensitive bands decreases with increasing EUC1 3 concentration, contrary to the common opinion that complexation increases the intensity of hypersensitive bands.
Structural Investigation of the Metallic Glasses Mg85.5Cu14.5 and Mg70Zn30
Authors: Nassif E. , Lamparter P. , Sperl W. , Steeb S. 
Published: February 2015

Abstract
The total structure factors as well as the total pair correlation functions for amorphous Mg85.5Cu14.5 (by neutron and X-ray diffraction) and for amorphous Mg70Zn30 (by X-ray diffraction) were determined. Both alloys show similar chemical short range order effects. From the total pair correlation function of the Mg85.5Cu14.5 glass, partial coordination numbers and atomic distances could be extracted. Comparison with the structure of crystalline Mg2Cu suggests that the short range order around the copper atoms is similar in the amorphous and the crystalline phase. The densities of both amorphous alloys were measured yielding negative excess volumina.
The Rotational Spectra of Fluorinated Acetonitriles; 14N-nuclear Quadrupole Hyperfine Structures Measured with a Microwave Fourier Transform Spectrometer
Authors: Kasten W. , Dreizler H. , Job Brian E. , Sheridan John 
Published: February 2015

Abstract
The microwave spectra of CF3CN, CH2FCN, CHDFCN, CD2FCN and CHF2CN have been measured and analysed. The nuclear quadrupole hyperfine splittings due to 14N have been measured by Microwave Fourier Transform spectroscopy. The nuclear quadrupole coupling constants, transformed to the bonding axis systems of the C-C ≡ N groups, are shown to be in accord with structural predictions of the p-electron populations at the nitrogen atom.
Die Wasserstoff-Palladium-Bindung bei Adsorption des Wasserstoffs an den (100)-und (111)-Oberflächen sowie Diffusion und Absorption im Kristallgitter aus der Sicht der SW-Xα-Methode / Investigation of the hydrogen-palladium bond of hydrogen being adsorbed on the (100)- and (111)-surfaces, diffusing and being absorbed in the crystal-lattice using the SW-Xα-method
Authors: Fritsche Hans-Gerhard 
Published: February 2015

Abstract
SW-Xα-calculations pf PdnH-and Pdn-clusters of Oh -, Td -, C4v -and C3v -symmetry are carried out to investigate the bonding mechanism of hydrogen being chemisorbed at the (100)- and (111)-surfaces, entering the lattice and being absorbed at interstitial sites. Densities of states, local electron densities, spherical electron densities, integral electron charges as well as maps of the main H-Pd bonding orbital are compared in order to characterize the hydrogen-palladium bond.
Diode Laser Spectrum of HCCCN: CN Stretching Band
Authors: Yamada Koichi , Best Regina , Winnewisser G. 
Published: February 2015

Abstract
The ν2 vibration-rotation band of cyanoacetylene. HCCCN, has been studied by diode laser spectroscopy in the wavenumber region from 2240 cm-1 to 2290 cm-1. In addition to the fundamental band we have assigned hot bands arising from v7 = 1. 2. and 3 states and from v6 = 1 state. In these hot bands splittings due to l-type doubling and l-type resonance were clearly observed. The transition wavenumbers were measured precisely, with an estimated error of 0.001 cm-1. Their analysis simultaneously with the microwave data allowed an accurate determination of the band origin v0 = 2273.99539(11) cm-1, the rotational constant B′ = 4527.4861 (28) MHz. and the centrifugal distortion constant D′ = 0.53547(43) kHz.
Model Calculations on One-Dimensional (1D) Poly-Decker Sandwich Compounds. A Crystal Orbital Investigation Based on the Tight-Binding Formalism
Authors: Böhm Michael C. 
Published: February 2015

Abstract
The band structures of 11 one-dimensional (ID) poly-decker sandwich compounds with dif­ferent transition metal centers M (M = Mn, Fe, Co, Ni, Cu, Zn) and a variety of fivemembered π ligands L from the cyclopentadienyl moiety (C5H5) to the pure boron ring B5H5 have been studied by means of a semiempirical crystal orbital procedure based on the INDO approxima­tion in order to allow a priori predictions on possible semiconducting or conducting low-dimen­sional materials composed by ML fragments. To determine the (numerically) different self­energy corrections (i.e. long-range and short-range “correlations”) in the transition metal 3d spines and the ligand backbones approximate quasi-particle shifts have been employed for the correction of the Hartree-Fock (HF) band energies. The band structure properties (e.g., dispersion curves, density of states distributions, effective mass parameters, propagation times of charge carriers) are discussed in the light of the semiempirical tight-binding approach. It is shown that the forbidden band gaps are reduced with an increasing number of B atoms in the π ligands. The gap in the Mn(C5H5) stack amounts to 8.27 eV, while overlapping dispersion curves are predicted in the Zn(B5H5) derivative. This model polymer is the only intrinsic conductor in the series of the studied ID metallocenes; all other compounds require injected charge carriers (electrons or holes) in order to achieve partially filled bands. Injected holes in the Mn or Fe backbones lead to ID materials with conducting 3d spines; the charge transfer in this regime is best described as some type of hopping motion. The remaining poly-decker strands belong to the class of organic metals (injected carriers) with conductive pathways that are formed by diffuse ligand states leading to transfer processes that can be rationalized in terms of a band picture. The rotational profiles and the magnitudes of intracell and intercell interactions are also studied. The band structure properties (band gaps, characters of the valence and conduction bands) depend critically on the mutual orientations between neighbouring unit cells in the case of ligands with low spatial symmetries. General rules and strategies for synthetic approaches to organometallic ID materials containing 3d centers with small or vanishing band gaps are formulated.
High Temperature Study of Molecular Motion in Polyphenylene Sulfide by Thermally Stimulated Currents
Authors: Jurga Jan , Hruszka Przemysław , Hilczer Bożena , Kułek Jan 
Published: February 2015

Abstract
Thermally stimulated currents (TSC) in polyphenylene sulfide were measured in unpolarized and polarized samples. The TSC thermograms show a rapid increase in current at about 200 °C with an activation energy of about 1.6 eV. Additionally, in polarized samples a peak at about 150 °C related with the reorientational motions of the chain was found.
Langmuir's Helium-Like Models Revisited
Authors: Dimitrijević M. S. , Grujić P. V. 
Published: February 2015

Abstract
Classical two-electron configurations, proposed by Langmuir in the days of Old Quantum Theory as models for helium-like atoms, have been examined making use of modern semiclassical theory for the periodic orbits quantization. Combining both analytical and numerical investigations, energy spectra for the rotor-like and oscillator-like models have been evaluated, for the nuclear charges Z = 1, 2, 3, 6. No essential improvement of the original result (for Z = 2) is obtained, signifying that either configuration turns out to be inferior to the simple Bohr's planetary model. Stability of these systems with respect to small perturbations has been examined and a general criterion for selecting classical models as candidates for atomic orbitals within the semiclassical theory is discussed.
Dolomite Decomposition to (Ca,Mg)O Solid Solutions: An X-Ray Diffraction Study.Part II.
Authors: Spinolo G. , Tamburini U. Anselmi 
Published: February 2015

Abstract
The full decomposition of dolomites with low and high iron content at low temperatures and low pressures is discussed with reference to the free energy of mixing of the ternary system Ca. Fe, Mg/O. The actual products of the primary step are a couple of rock salt structured oxides close to the spinodal compositions and with very small particle sizes. A subsequent diffusional process can produce large crystallites with equilibrium compositions, but it is effective only when either a low-iron dolomite is used as starting material or higher temperatures are employed.
Dielectric and Pyroelectric Properties of Lithium Hydrogen Dimalate, LiH3(C4H4O5)2
Authors: Fleck Silvia , Weiss Alarich 
Published: February 2015

The dielectric constant and the pyroelectric coefficient at constant stress of 1-lithium hydrogen dimalate 1-Li⊕(OOCCHOHCH2COOH)⊖(HOOCCHOHCH2COOH), were investigated in the temperature range 200 ≦ T / K ≦ Td (decomposition temperature) and 100 ≦ T / K ≦ Td, respectively. The compound crystallizes in the space group P21. In the direction of the 21 axis ε'22 increases with almost constant slope with increasing temperature from 7.32 (200 K) to 8.55 (360 K). The pyroelectric coefficient p2 shows a maximum at 152 K and a minimum at 290 K; p2 lies between 15 μC m-2 K-1 and 6 μC m-2 K-1. The contribution of the lattice to the polarization was calculated on the basis of a point charge model developed from a charge distribution calculation on the INDO basis. Assuming certain lattice vibration frequencies and a harmonic oscillator model, p2 = ƒ(T) was calculated.
Qualitatively the calculations are in satisfactory agreement with the experiment.