bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preferential phenotypic association linked with cooperation in paper wasps
Authors: Tibbetts E. A. , Injaian A. 
Published: September 2013

AbstractAnimals can influence their social environment by preferentially associating with certain conspecifics. Such preferential association has gained increasing theoretical attention, as it may influence social evolution and population dynamics. However, relatively little empirical work has examined the occurrence of preferential association and its effects on cooperative group formation. Here, we test the factors associated with cooperative group formation inPolistes dominulusnest‐founding queen wasps.P. dominulusare a good system to study preferential association, as foundresses can nest alone or in groups and group membership is flexible. We found that both social and environmental factors were associated with partner choice. First, facial patterns were associated with cooperation. Wasps with more similar facial patterns were more likely to cooperate than wasps with less similar facial patterns. This preferential phenotypic association fits the theoretical criteria for the evolution of tag‐based cooperation. Season was also associated with cooperation; wasps on early‐season nests were more likely to cooperate than wasps on late‐season nests. High levels of aggression by nest owners during initial interactions were also correlated with lower probabilities of subsequent cooperation, suggesting that nest owners have some control over group membership. Other factors including body weight, weight similarity and nest productivity were not linked with cooperation. Overall, multiple factors influence cooperation in paper wasps, including facial pattern similarity. The occurrence of preferential phenotypic association in paper wasps is quite interesting and may influence the evolution of cooperation and population divergence in this group.
Change to Either a Nonandrogenic or Androgenic Progestin-Containing Oral Contraceptive Preparation is Associated with Improved Sexual Function in Women with Oral Contraceptive-Associated Sexual Dysfunction
Authors: Davis Susan R. , Bitzer Johannes , Giraldi Annamaria , Palacios Santiago , Parke Susanne , Serrani Marco , Mellinger Uwe , Nappi Rossella E. 
Published: September 2013

ABSTRACT

Introduction
It is a commonly held belief that combined oral contraceptive (COC) pills containing an androgenic progestin may be less likely to impair sexual function than COCs containing an anti-androgenic progestin.

Aim
The study aims to compare the effects of a COC containing a progestin with an anti-androgenic profile (estradiol valerate [E2V]/dienogest [DNG]) to that of one with an androgenic progestin (ethinyl estradiol [EE]/levonorgestrel [LNG]) on sexual function in women with COC-associated sexual dysfunction.

Methods
In this multicenter, randomized, double-blind, noninferiority study, women with COC-associated female sexual dysfunction (FSD) were randomized to E2V/DNG or EE/LNG for six cycles. The primary outcome was the change in the sum of Female Sexual Function Index (FSFI) desire and arousal component scores between baseline and cycle 6. Secondary outcome measures included changes to the FSFI domains, the Female Sexual Distress Scale (FSDS-R), Vaginal Health Assessment, the Atrophy Symptom Questionnaire, and the Psychological General Well Being Index over six treatment cycles.

Main Outcome Measure
The main outcome is the change in the sum of FSFI desire and arousal component scores between baseline and cycle 6.

Results
Of 276 women screened, 213 received treatment and 191 completed the study. The mean increase in the sum of FSFI desire and arousal component scores was 5.90 (standard deviation [SD] 5.45) for E2V/DNG and 5.79 (SD 6.17) for EE/LNG (change from baseline P &lt; 0.0001, both groups). Both treatments showed equal efficacy and were associated with improvements in all domains of the FSFI, with no between-group differences. Both COCs reduced the distress associated with FSD, as indicated by reduced FSDS-R scores.

Conclusion
In women with COC-associated FSD, switching to either E2V/DNG or EE/LNG was associated with equivalent improvements in symptoms, challenging the perception that COCs containing anti-androgenic progestins have a detrimental effect on sexual function relative to those containing androgenic progestins.
Stable isotope analysis of carbon and nitrogen in angrites
Authors: Abernethy F. A. J. , Verchovsky A. B. , Starkey N. A. , Anand M. , Franchi I. A. , Grady Monica M. 
Published: September 2013

AbstractAngrites are a small group of ancient basaltic achondrites, notable for their unusual chemistry and extreme volatile depletion. No comprehensive study of indigenous light elements currently exists for the group. Measurement of the abundances and isotopic composition of carbon and nitrogen could provide information pertaining to the evolution of the angrite parent body. Bulk‐sample stepped combustion analyses of five angrites and a glass separate from D'Orbigny were combined with earlier data and acid dissolution experiments of carbonates found in D'Orbigny to compile an inventory of indigenous carbon and nitrogen. Indigenous carbon combusted between 700 °C and 1200 °C, with abundances of 10–140 ppm and a mass‐weighted δ13C of −25 to −20‰ with the exception of D'Orbigny (δ13C approximately −5‰). Nitrogen was released at 850–1200 ºC, 1–20 ppm with a δ15N −3‰ to +4‰; again, D'Orbigny (δ15N approximately +20 to +25‰) was an exception. We interpret these components as largely indigenous and decoupled; the carbon in graphitic or amorphous form, while the nitrogen is present as a dissolved component in the silicates. No relationship with the textural sub‐classification of angrites is apparent. We suggest that the angrite parent body contains a reservoir of reduced carbon and thus may have undergone a change in redox conditions, although the timing and mechanism for this remain unclear.
An inordinate fondness for beetles? Variation in seasonal dietary preferences of night‐roosting big brown bats (Eptesicus fuscus)
Authors: Clare Elizabeth L. , Symondson William O. C. , Fenton Melville Brockett 
Published: September 2013

AbstractGeneralist species with numerous food web interactions are thought to provide stability to ecosystem dynamics; however, it is not always clear whether habitat generality translates into dietary diversity. Big brown bats are common across North America and employ a flexible foraging strategy over water, dense forests, forest edges and rural and urban settings. Despite this generalist use of habitat, they are paradoxically characterized as beetle specialists. However, hard carapaces may preferentially survive digestion leading to over‐representation during morphological analysis of diet. This specialization has not been evaluated independently using molecular analysis and species‐level identification of prey. We used next‐generation sequencing to assess the diet of big brown bats. Beetles were consumed in the highest frequency but Lepidoptera species richness was highest among identified prey. The consumption of species showed strong seasonal and annual variation. While Coleoptera consumption varied, Lepidoptera and Ephemeroptera were relatively constant dietary components. Dietary diversity increased in late summer when insect diversity decreases. Our results indicate that big brown bats are dietary generalists and, while beetles are an important component of the diet, Lepidoptera are equally important, and Lepidoptera and Ephemeroptera are the only stable prey resource exploited. As resources become limited, big brown bats may respond by increasing the species richness of prey and thus their connectedness in the ecosystem. This characterization of diet corresponds well with a generalist approach to foraging, making them an important species in encouraging and maintaining ecosystem stability.
A Tabu Search Method for a Bi‐Objective Urban Waste Collection Problem
Authors: Gómez José Rubén , Pacheco Joaquín , Gonzalo‐Orden Hernán 
Published: September 2013

AbstractA bi‐objective model for the collection of waste bins in rural areas within a planning period is analyzed. This model is a real problem raised by local authorities in a rural region of northwestern Spain. The two objectives under consideration are: minimization of transport costs and improvements to the level of service. Specifically, the level of service depends on the frequency of waste collection at each point over the planning period. A solution method for this problem was developed by applying tabu search within the framework of Multiobjective Adaptive Memory Programming (MOAMP) and the results were compared with an implementation of NSGA‐II, a well‐known approach to multiobjective optimization.
Independent target region amplification polymorphism and single‐nucleotide polymorphism marker utility in genetic evaluation of sugarcane genotypes
Authors: Devarumath Rachayya M. , Kalwade Sachin B. , Bundock Peter , Eliott Frances G. , Henry Robert 
Published: September 2013

AbstractThe independent target region amplification polymorphism (TRAP) and single‐nucleotide polymorphism (SNP) markers were used for genetic evaluation of different selected 47 sugarcane genotypes. A total of 23 pairs of TRAP markers generated 925 alleles, of which 74% alleles were polymorphic. Polymorphism was generally high (>50%), ranging from 54 to 98%. The polymorphism information content (PIC) values 0.20 varied among the primer combination ranging from 0.17 in SAI + Arbi 2 to 0.31 in GL 2+ Arbi 1 with an average of 0.24. However, the Pearson correlation between PIC and power of discrimination (PD) was found to be less significant. Single‐nucleotide polymorphisms were used first time for the assessment of genetic diversity among different species of Saccharum and cultivated sugarcane varieties. The SNPs were detected from 454 sequencing. A total of 245 SNP markers were assayed across the 47 genotypes, and 167 SNPs were found to be polymorphic. The PIC values ranged from 0.04 to 0.38 with an average of 0.21, and their respective PD varied from 0.58 to 0.04 with an average value of 0.31. The obtained results relatively significant were compared with the other marker systems through genetic similarity and the clusters formed in different unweighted pair group method with arithmetic mean clustering dendrogram. The clustering analysis established genetic relationship in the order of Erianthus > Sclerostachya > Narenga > Saccharum spontaneum > S. robustum > S. barberi > S. officinarum/cultivars. These results ratify TRAP and SNP marker systems for assessing genetic diversity studies, and more diversified Erianthus spp. can contribute substantially towards sugarcane varietal improvement through breeding with Saccharum spp. or hybrid cultivars.
Underground Markets as Fields in Transition: Sex Work in New York City
Authors: Venkatesh Sudhir 
Published: September 2013

Most ethnographers visualize their fieldwork study vis‐à‐vis their long‐term commitment to a bounded sociospatial context—an “ecology.” In this manner, the majority of ethnographic studies are presented as studies not only of practices but also of recognizable physical ecologies that breathe life into the practices—for example, homes, ghettos, firms, schools, and so on. In the pages that follow, I consider the ways in which the status of place has shifted in urban sex work. The shifting commerce of sexual services in New York enables me to open up a set of methodological issues about the role of space in ethnographic work. One in particular is at the core of this paper: namely, because so many ethnographic labors begin with the selection of a field site, what conceptual issues arise that fieldworkers must pay attention to vis‐à‐vis that decision? For example, the field site may change, the field site may itself be shaped by wider societal forces, and it may be simply dissolve over time. How does any of this impact a technique that is premised on the dependability of “sitting” so that others may be dependably followed? I draw on the notion of “strategic action fields” to present an alternative analytic framework, one more useful for the challenges ethnographers face.
Serial viscoelastic and traditional coagulation testing in horses with gastrointestinal disease
Authors: Epstein Kira L. , Brainard Benjamin M. , Giguere Steeve , Vrono Zachary , Moore James N. 
Published: September 2013

AbstractObjectiveObjectives of this study were to compare the ability of serial thromboelastography, Sonoclot, and traditional coagulation panels to detect coagulopathies associated with disease category, systemic inflammatory response syndrome (SIRS), complications, and nonsurvival in horses with gastrointestinal disease.DesignProspective clinical evaluation.SettingUniversity referral hospital.AnimalsOne hundred twenty‐one horses admitted as emergencies for gastrointestinal disease and 28 healthy adult horses.InterventionBlood samples were collected ≤4 times from emergency horses (admission and if surviving and hospitalized on days 2–4) and once from healthy horses. Thromboelastography (with and without tissue factor activation), Sonoclot, and a traditional coagulation panel were performed on each sample.Measurements and Main ResultsEmergency horses were grouped based on disease category (ie, nonstrangulating medical, nonstrangulating surgical, strangulating, and inflammatory), survival to discharge, SIRS at admission, requirement for exploratory celiotomy, ileus, diarrhea, fever, thrombophlebitis, and laminitis. Changes over time were evaluated individually and compared between disease groups. Horses with gastrointestinal disease had dynamic changes in coagulation and fibrinolysis during the first 4 days of hospitalization that were correlated with disease category, SIRS, complications, and fatality. The multivariate logistic regression model for nonsurvival included activated partial thromboplastin time on day 2 and LY30 on day 3 (overall model significanceP< 0.0001). The odds of nonsurvival were 23.75 times higher if activated partial thromboplastin time was >85.6 s on day 2 and 9.38 times higher if LY30 was >1% on day 3.ConclusionsHorses with gastrointestinal disease have activation of coagulation and fibrinolysis. Magnitude of change in these parameters is small and predictive value moderate, making application of these tests to direct therapy in clinical patients difficult. Effect of specific treatments (eg, surgery) on these tests and coagulation has not been determined. Further studies are required to determine if these tests could be used to help monitor response to treatment in individual animals or specific disease states.
Mucosal Immunization with High-Mobility Group Box 1 in Chitosan Enhances DNA Vaccine-Induced Protection against Coxsackievirus B3-Induced Myocarditis
Authors: Wang Maowei , Yue Yan , Dong Chunsheng , Li Xiaoyun , Xu Wei , Xiong Sidong 
Published: September 2013

ABSTRACTCoxsackievirus B3 (CVB3), a small single-stranded RNA virus, belongs to thePicornaviridaefamily. Its infection is the most common cause of myocarditis, with no vaccine available. Gastrointestinal mucosa is the major entry port for CVB3; therefore, the induction of local immunity in mucosal tissues may help control initial viral infections and alleviate subsequent myocardial injury. Here we evaluated the ability of high-mobility group box 1 (HMGB1) encapsulated in chitosan particles to enhance the mucosal immune responses induced by the CVB3-specific mucosal DNA vaccine chitosan-pVP1. Mice were intranasally coimmunized with 4 doses of chitosan-pHMGB1 and chitosan-pVP1 plasmids, at 2-week intervals, and were challenged with CVB3 4 weeks after the last immunization. Compared with chitosan-pVP1 immunization alone, coimmunization with chitosan-pHMGB1 significantly (P< 0.05) enhanced CVB3-specific fecal secretory IgA levels and promoted mucosal T cell immune responses. In accordance, reduced severity of myocarditis was observed in coimmunized mice, as evidenced by significantly (P< 0.05) reduced viral loads, decreased myocardial injury, and increased survival rates. Flow cytometric analysis indicated that HMGB1 enhanced dendritic cell (DC) recruitment to mesenteric lymph nodes and promoted DC maturation, which might partly account for its mucosal adjuvant effect. This strategy may represent a promising approach to candidate vaccines against CVB3-induced myocarditis.
Diversity of Methicillin-Resistant Staphylococcus aureus Strains Isolated from Residents of 26 Nursing Homes in Orange County, California
Authors: Hudson Lyndsey O. , Reynolds Courtney , Spratt Brian G. , Enright Mark C. , Quan Victor , Kim Diane , Hannah Paul , Mikhail Lydia , Alexander Richard , Moore Douglas F. , Godoy Daniel , Bishop Cynthia J. , Huang Susan S. 
Published: September 2013

ABSTRACT

Nursing homes represent a unique and important methicillin-resistant
Staphylococcus aureus
(MRSA) reservoir. Not only are strains imported from hospitals and the community, strains can be transported back into these settings from nursing homes. Since MRSA bacteria are prevalent in nursing homes and yet relatively poorly studied in this setting, a multicenter, regional assessment of the frequency and diversity of MRSA in the nursing home reservoir was carried out and compared to that of the MRSA from hospitals in the same region. The prospective study collected MRSA from nasal swabbing of residents of 26 nursing homes in Orange County, California, and characterized each isolate by
spa
typing. A total of 837 MRSA isolates were collected from the nursing homes. Estimates of admission prevalence and point prevalence of MRSA were 16% and 26%, respectively. The
spa
type genetic diversity was heterogeneous between nursing homes and significantly higher overall (77%) than the diversity in Orange County hospitals (72%). MRSA burden in nursing homes appears largely due to importation from hospitals. As seen in Orange County hospitals, USA300 (sequence type 8 [ST8]/t008), USA100 (ST5/t002), and a USA100 variant (ST5/t242) were the dominant MRSA clones in Orange County nursing homes, representing 83% of all isolates, although the USA100 variant was predominant in nursing homes, whereas USA300 was predominant in hospitals. Control strategies tailored to the complex problem of MRSA transmission and infection in nursing homes are needed in order to minimize the impact of this unique reservoir on the overall regional MRSA burden.
Baculovirus F-Box Protein LEF-7 Modifies the Host DNA Damage Response To Enhance Virus Multiplication
Authors: Mitchell Jonathan K. , Byers Nathaniel M. , Friesen Paul D. 
Published: September 2013

ABSTRACT

The DNA damage response (DDR) of a host organism represents an effective antiviral defense that is frequently manipulated and exploited by viruses to promote multiplication. We report here that the large DNA baculoviruses, which require host DDR activation for optimal replication, encode a conserved replication factor, LEF-7, that manipulates the DDR via a novel mechanism. LEF-7 suppresses DDR-induced accumulation of phosphorylated host histone variant H2AX (γ-H2AX), a critical regulator of the DDR. LEF-7 was necessary and sufficient to block γ-H2AX accumulation caused by baculovirus infection or DNA damage induced by means of pharmacological agents. Deletion of LEF-7 from the baculovirus genome allowed γ-H2AX accumulation during virus DNA synthesis and impaired both very late viral gene expression and production of infectious progeny. Thus, LEF-7 is essential for efficient baculovirus replication. We determined that LEF-7 is a nuclear F-box protein that interacts with host S-phase kinase-associated protein 1 (SKP1), suggesting that LEF-7 acts as a substrate recognition component of SKP1/Cullin/F-box (SCF) complexes for targeted protein polyubiquitination. Site-directed mutagenesis demonstrated that LEF-7's N-terminal F-box is necessary for γ-H2AX repression and
Autographa californica
multiple nucleopolyhedrovirus (AcMNPV) replication events. We concluded that LEF-7 expedites virus replication most likely by selective manipulation of one or more host factors regulating the DDR, including γ-H2AX. Thus, our findings indicate that baculoviruses utilize a unique strategy among viruses for hijacking the host DDR by using a newly recognized F-box protein.
Lower extremity performance following ACL rehabilitation in the KANON-trial: impact of reconstruction and predictive value at 2 and 5 years
Authors: Ericsson Ylva B , Roos Ewa M , Frobell Richard B 
Published: September 2013

BackgroundThe additional effect of anterior cruciate ligament (ACL) reconstruction on muscle strength and physical performance after a structured exercise programme is not well understood.ObjectivesTo investigate and compare muscle strength and physical performance test results after a structured exercise programme, in young active adults with acute ACL injury, between those treated with and without ACL reconstruction (ACLR) and to evaluate these test results as predictors of clinical outcomes 2 and 5 years after injury.Study designProspective cohort study.MethodsIn a treatment randomised controlled trial of acute ACL injury (the KANON-study), 87/121 young active adults underwent two muscle strength tests and five physical performance tests after a structured exercise programme (median 37 (IQR 24) weeks after injury). Results were presented and compared as limb symmetry indices (LSI); endpoints in predictive analyses were having a delayed ACLR over the first 5 years and self-reported knee function (Knee injury and Osteoarthritis Outcome Score; KOOS4) at 2 and 5 years.ResultsOverall, 74–95% of patients had LSI≥90% in the individual tests, with no difference between treatment groups (p=0.08–0.92). Results of the one-leg rise tests predicted KOOS4at 2 and 5 years (R2=0.25 and 0.24, p=0.001 and 0.002) and vertical hop results predicted having a delayed ACLR over a 5-year course after injury (p=0.048) in those starting with exercise alone (n=21).ConclusionsAfter an acute ACL tear, the majority of young active adults regain physical performance and muscle strength after a structured exercise programme, with or without surgical reconstruction. Poor physical performance at the end of rehabilitation predicted worse patient-reported outcomes at 2 and 5 years regardless of treatment.Registration number:ISRCTN84752559.