bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark 
Published: July 2024

Abstract

High-dose intravenous vitamin C (HDIVC) administered to produce pharmacologic concentrations shows promise in preclinical models and small clinical trials, but larger prospective randomized trials are lacking. We evaluated the clinical benefit of combining HDIVC with docetaxel in patients with progressive metastatic castration-resistant prostate cancer (mCRPC). In this double-blind, placebo-controlled phase II trial, 47 patients were randomized 2:1 to receive docetaxel (75 mg/m2 i.v.) with either HDIVC (1 g/kg) or placebo. Coprimary endpoints were PSA50 response and adverse event rates. Secondary endpoints included overall survival, radiographic progression-free survival, and quality of life measured using the Functional Assessment of Cancer Therapy-Prostate instrument. Correlative analyses included pharmacokinetics and oxidative stress markers. Eighty-nine percent of patients previously had three or more lines of therapy. The PSA50 response rate was 41% in the HDIVC group and 33% in the placebo group (P = 0.44), with comparable adverse event rates in both groups. There were no significant differences in Functional Assessment of Cancer Therapy-Prostate scores. The median radiographic progression-free survival was not significantly different between the HDIVC and placebo groups, with durations of 10.1 and 10.0 months (HR, 1.35; 95% confidence interval, 0.66–2.75; P = 0.40), respectively. The median overall survival was 15.2 months in the HDIVC group and 29.5 months in the placebo group (HR, 1.98; 95% confidence interval, 0.85–4.58; P = 0.11). HDIVC did not decrease F2-isoprostanes, indicators of oxidative stress. The study was suspended after prespecified interim analysis indicated futility in achieving primary endpoints. In this patient population, combining HDIVC with docetaxel did not improve PSA response, toxicity, or other clinical outcomes compared with docetaxel alone. Findings do not support the routine use of HDIVC in mCRPC treatment outside of clinical trials.

Significance:
This is the first randomized, placebo-controlled, double-blind trial to evaluate HDIVC in cancer treatment. The addition of HDIVC to docetaxel in patients with mCRPC does not improve PSA response, toxicity, or other clinical outcomes compared with docetaxel alone. The routine use of HDIVC in mCRPC treatment is not supported outside of clinical trials.
Perception of Phonological Assimilation by Neural Speech Recognition Models
Authors: Pouw Charlotte , Kloots Marianne de Heer , Alishahi Afra , Zuidema Willem 
Published: July 2024

Abstract
Human listeners effortlessly compensate for phonological changes during speech perception, often unconsciously inferring the intended sounds. For example, listeners infer the underlying /n/ when hearing an utterance such as “clea[m] pan”, where [m] arises from place assimilation to the following labial [p]. This article explores how the neural speech recognition model Wav2Vec2 perceives assimilated sounds, and identifies the linguistic knowledge that is implemented by the model to compensate for assimilation during Automatic Speech Recognition (ASR). Using psycholinguistic stimuli, we systematically analyze how various linguistic context cues influence compensation patterns in the model’s output. Complementing these behavioral experiments, our probing experiments indicate that the model shifts its interpretation of assimilated sounds from their acoustic form to their underlying form in its final layers. Finally, our causal intervention experiments suggest that the model relies on minimal phonological context cues to accomplish this shift. These findings represent a step towards better understanding the similarities and differences in phonological processing between neural ASR models and humans.
Do Multimodal Large Language Models and Humans Ground Language Similarly?
Authors: Jones Cameron R. , Bergen Benjamin , Trott Sean 
Published: July 2024

Abstract
Large Language Models (LLMs) have been criticized for failing to connect linguistic meaning to the world—for failing to solve the “symbol grounding problem.” Multimodal Large Language Models (MLLMs) offer a potential solution to this challenge by combining linguistic representations and processing with other modalities. However, much is still unknown about exactly how and to what degree MLLMs integrate their distinct modalities—and whether the way they do so mirrors the mechanisms believed to underpin grounding in humans. In humans, it has been hypothesized that linguistic meaning is grounded through “embodied simulation,” the activation of sensorimotor and affective representations reflecting described experiences. Across four pre-registered studies, we adapt experimental techniques originally developed to investigate embodied simulation in human comprehenders to ask whether MLLMs are sensitive to sensorimotor features that are implied but not explicit in descriptions of an event. In Experiment 1, we find sensitivity to some features (color and shape) but not others (size, orientation, and volume). In Experiment 2, we identify likely bottlenecks to explain an MLLM’s lack of sensitivity. In Experiment 3, we find that despite sensitivity to implicit sensorimotor features, MLLMs cannot fully account for human behavior on the same task. Finally, in Experiment 4, we compare the psychometric predictive power of different MLLM architectures and find that ViLT, a single-stream architecture, is more predictive of human responses to one sensorimotor feature (shape) than CLIP, a dual-encoder architecture—despite being trained on orders of magnitude less data. These results reveal strengths and limitations in the ability of current MLLMs to integrate language with other modalities, and also shed light on the likely mechanisms underlying human language comprehension.
Exploring Temporal Sensitivity in the Brain Using Multi-timescale Language Models: An EEG Decoding Study
Authors: Ling Sijie , Murphy Alex , Fyshe Alona 
Published: July 2024

Abstract
The brain’s ability to perform complex computations at varying timescales is crucial, ranging from understanding single words to grasping the overarching narrative of a story. Recently, multi-timescale long short-term memory (MT-LSTM) models (Mahto et al. 2020; Jain et al. 2020) have been introduced, which use temporally tuned parameters to induce sensitivity to different timescales of language processing (i.e., related to near/distant words). However, there has not been an exploration of the relationship between such temporally tuned information processing in MT-LSTMs and the brain’s processing of language using high temporal resolution recording modalities, such as electroencephalography (EEG).
To bridge this gap, we used an EEG dataset recorded while participants listened to Chapter 1 of “Alice in Wonderland” and trained ridge regression models to predict the temporally tuned MT-LSTM embeddings from EEG responses. Our analysis reveals that EEG signals can be used to predict MT-LSTM embeddings across various timescales. For longer timescales, our models produced accurate predictions within an extended time window of ±2 s around word onset, while for shorter timescales, significant predictions are confined to a narrower window ranging from −180 ms to 790 ms. Intriguingly, we observed that short timescale information is not only processed in the vicinity of word onset but also at more distant time points.
These observations underscore the parallels and discrepancies between computational models and the neural mechanisms of the brain. As word embeddings are used more as in silico models of semantic representation in the brain, a more explicit consideration of timescale-dependent processing enables more targeted explorations of language processing in humans and machines.
The Diagrammatics of ‘Race’
Authors: Sommer Marianne 
Published: July 2024

This is the first book that engages with the history of diagrams in physical, evolutionary, and genetic anthropology. Since their establishment as scientific tools for classification in the eighteenth century, diagrams have been used to determine but also to deny kinship between human groups. In nineteenth-century craniometry, they were omnipresent in attempts to standardize measurements on skulls for hierarchical categorization. In particular the ’human family tree’ was central for evolutionary understandings of human diversity, being used on both sides of debates about whether humans constitute different species well into the twentieth century. With recent advances in (ancient) DNA analyses, the tree diagram has become more contested than ever―does human relatedness take the shape of a network? Are human individual genomes mosaics made up of different ancestries? Sommer examines the epistemic and political role of these visual representations in the history of ‘race’ as an anthropological category. How do such diagrams relate to imperial and (post-)colonial practices and ideologies but also to liberal and humanist concerns?
The Diagrammatics of 'Race' concentrates on Western projects from the late 1700s into the present to diagrammatically define humanity, subdividing and ordering it, including the concomitant endeavors to acquire representative samples―bones, blood, or DNA―from all over the world. Contributing to the ‘diagrammatic turn’ in the humanities and social sciences, it reveals connections between diagrams in anthropology and other visual traditions, including in religion, linguistics, biology, genealogy, breeding, and eugenics.
Factors and Beliefs Affecting Women Diagnosed With Breast Cancer to Initiate Cancer Treatment: A Systematic Review
Authors: Almallah Walaa R. , Bakas Tamilyn , Shaughnessy Elizabeth , Morrison Caroline F. 
Published: July 2024

Background: Initiating treatment within the optimal time is critical for women with breast cancer. A delay in cancer treatment initiation can result in increased morbidity and mortality and decreased overall survival. Objective: This systematic review aims to investigate the literature for the factors and beliefs affecting women diagnosed with breast cancer with regard to initiating cancer treatment. Methods: The PubMed, CINAHL, and PsycINFO databases were searched using the terms of breast cancer, initiating or seeking treatment, and beliefs. The Johns Hopkins Evidence-Based Practice Research Evidence Appraisal Tool was used to evaluate the included articles. Results: Sixteen articles were included in this review. The addressed factors were classified as (1) patient-related factors, (2) disease-related factors, (3) provider-related factors, and (4) system-related factors. The identified beliefs were cultural beliefs and perceived barriers to initiating treatment. Conclusion: Although the literature reported multiple factors and beliefs that impact the time of initiating treatment among women with breast cancer, more research is needed to fully understand the beliefs influencing treatment initiation. It is essential to address and screen the factors and beliefs identified for women diagnosed with breast cancer to enhance treatment initiation early and prevent any possible delay. Interventions can be developed to overcome the factors and beliefs that may lead to late treatment initiation. Advocacy for new policies should be in action to reduce the disparities associated with treatment initiation among women with breast cancer.
Efficacy and safety of ertapenem dosing in patients with ESBL producing Enterobacterales infections utilizing renal replacement therapies
Authors: El Nekidy Wasim S , Ghazal Iyad , Abidi Emna , Malaeb Diana , Ghazi Islam M , El Lababidi Rania , Mooty Mohamad , Malik Amir , Ghosn Muriel , Mallat Jihad 
Published: July 2024

Purpose: The clinical efficacy and safety of ertapenem use in patients undergoing renal replacement therapies (RRT) are not well-documented. Therefore, we aimed to investigate the safety and efficacy of ertapenem in patients with sepsis secondary to Enterobacterales who are undergoing RRT. Methods: A retrospective cohort study was conducted on patients who met the inclusion criteria at our hospital between May 2015 and December 2021. The primary endpoint was 30-day mortality. Secondary endpoints included clinical cure, microbiologic cure, recurrence rate, and incidence of seizures. Results: During the study period, 158 patients met the inclusion criteria. Of these, 86 were male (54.4%), the mean age was 66.4 ± 13.8 years, and the mean weight was 77 ± 22.4 kg. The most common diagnosis was bacteremia in 48 (30.4%) subjects, followed by urinary tract infection in 39 (24.7%) subjects, and pneumonia in 35 (22.2%) patients. The most isolated pathogens were Escherichia coli, followed by Klebsiella species. The median ertapenem dose was 0.5 g intravenously (IV) daily in those who received intermittent hemodialysis (IHD) and 1 g IV daily for those who received continuous veno-venous hemofiltration (CVVH). The 30-day mortality rate was 24%, the clinical cure rate was 89.2%, the microbiologic cure rate was 82%, the 30-day recurrence rate was 41.1%, and the incidence of seizures was 2.5%. Multivariate logistic regression analysis indicated that age (OR 1.04 [95% CI: 1.003–1.075]), being critically ill at therapy initiation (OR 2.9 [95% CI: 1.1–7.5]), and Enterobacterales other than Klebsiella species and Escherichia coli (OR 3.8 [95% CI: 1.1–12.5]) were significant independent risk factors associated with mortality in this population. Ertapenem dose was not associated with mortality. Conclusion: Our findings suggest that the commonly used doses of ertapenem in patients undergoing IHD and CVVH are clinically effective but may pose a higher risk of seizures. A comprehensive pharmacokinetic study is needed to determine the most effective and safe dose for this population.
Comparing the acute toxicities of co-exposure to cocaine and ethanol versus cocaine alone
Authors: Cheung Kwun Lok , Lam Rex Pui Kin , Chan Chi Keung , Tse Man Li , Tsui Matthew Sik Hon , Rainer Timothy Hudson 
Published: July 2024

Introduction Cocaine is commonly consumed with ethanol, which leads to the formation of cocaethylene through transesterification. Cocaethylene is an active metabolite of cocaine with a longer duration of action. Literature on the combined toxicity of cocaine, ethanol, and cocaethylene is conflicting. We aimed to compare the acute toxicities of co-exposure to cocaine and ethanol versus cocaine alone in Hong Kong. Methods This was a retrospective study on acute cocaine toxicities reported to the Hong Kong Poison Control Center from 1 January 2010 to 22 January 2023. Cocaine exposure was confirmed by urine immunoassays/laboratory tests and ethanol co-ingestion was confirmed by blood ethanol concentrations. A serious outcome was defined as a National Poison Data System outcome moderate or above. Univariate analyses and multivariable logistic regression were performed to compare the associations of clinical outcomes with and without ethanol, followed by subgroup analyses of cases with complete data. Results We analyzed 109 patients (median age 29 years, 71% men, 68% Chinese), of whom 20 had confirmed ethanol co-ingestion (mean blood ethanol concentration 1350 mg/L). Multivariable analysis showed that co-exposure to cocaine and ethanol was associated with a lower risk of serious outcomes (adjusted odds ratio 0.09, 95% confidence interval 0.01–0.77; p = 0.03) after adjusting for age, sex, ethnicity, route of cocaine administration, and physical health status. Subgroup analyses showed similar findings. Conclusions In contrast to previous studies, we did not identify a higher risk of serious outcomes after co-exposure to cocaine and ethanol compared to cocaine alone in a predominantly Chinese cohort.
Exploring inappropriate levels of care in intensive care
Authors: D’Anjou Bénédicte , Ahern Stéphane , Martel Valérie , Royer Laetitia , Saint-André Anne-Charlotte , Vandal Esther , Racine Eric 
Published: July 2024

Background Levels of care deemed as inappropriate generate moral distress among nurses and other intensive care professionals. Inappropriate levels of care and related moral distress are frequently broached as individual and psychological phenomena, reduced to how individuals feel and think about specific cases. However, this tends to obscure the complex context in which these situations occur, and on which healthcare professionals can act. There is thus a need for a more contextual and team-level lens on inappropriate levels of care. Research objective This study aims to explore and understand the issue of inappropriate levels of care in an intensive care unit (ICU) through a contextual and team-level lens. Research design Semi-structured interviews were conducted with nurses, respiratory therapists, and intensivists. Thematic analysis focused on understanding the causes and consequences of inappropriate levels of care, as well as potential avenues for improvement. This study is part of a 5-phase participatory living lab project on inappropriate levels of care conducted in the ICU of a Montreal (Quebec, Canada) hospital. This paper relates the initial phases of the project, focusing on understanding the issue, with reported events spanning from June 2022 to May 2023. Ethical considerations Ethics approval was sought and granted by the Research Ethics Board of the CIUSSS de l’Est-de-l’Île-de-Montréal. Findings/Discussion Five broad themes intrinsically related to the phenomenon of inappropriate levels of care were explored with and by participants: (1) the process of determining levels of care, (2) the distinction between appropriate and inappropriate levels of care, (3) causes of inappropriate levels of care, (4) consequences of inappropriate levels of care and (5) potential avenues for improvement. Conclusion This research provides a comprehensive understanding of inappropriate levels of care in the ICU and emphasizes the relevance of team-level explorations of complex ethical issues.
Journeying with a bipolar disorder: The quest plot
Authors: Parker Gordon 
Published: July 2024

Objective Many with a bipolar disorder embark on a quest, most commonly during elevated mood states, and sometimes driven by a prescient delusion. This essay draws a parallel with a prominent literary plot – the Quest. Method Reference to the literary plot is made and an exemplar provided, being based on the personal stories of several patients. Results Parallels between the literary model and the current vignette are emphasized. Conclusion Manic prescience can sometimes be more than a delusion. The Quest is both a literary plot and at times may underlie manic behaviours and even illustrate its symbolic value.
Determinants of Hemoglobin Among Pregnant Women at Agro-Pastoralist Communities in South Omo Zone, Ethiopia: Community Based Cross-Sectional Study, Nutrition Experience from Movable Community
Authors: Alemu Tsegaye , Nkosi Zerish Zethu , Yakob Tigist 
Published: July 2024

Background: Low hemoglobin level is the most common public health problem during pregnancy in developing countries including Ethiopia, which is affecting both mother and fetus. However, the determinants of anemia among pregnant women are not well studied. Objective: To assess the determinates of hemoglobin among pregnant women in rural agro-pastoralist communities in the South Omo zone, Ethiopia Method: Community-based cross-sectional study was done in rural agro-pastoralist communities. A multistage stratified sampling technique was used to select 526 pregnant women. Data were collected by using structured questionnaires. Hemoglobin level was measured by using HemoCue ® Hb301. Data were analyzed by using a statistical package for the social science version 26. Descriptive (Mean, standard deviation, frequency, range), bivariate and multivariate analysis was carried out to check the association between lower hemoglobin levels and independent variables. The output is presented in tables and figures. Result: The mean (±SD) of hemoglobin concentration was 11.8 ± 1.7. The overall prevalence of anemia was 39.9% [95% CI: 35.5, 44.4], 19.4% (95% CI: 16.0, 23.2) was mild, 19.6% (95% CI: 16.27, 2.5) was moderate and 0.9% (95% CI: 0.25, 2.25) was severe anemia. Not taking IFA (AOR = 5.7(3.3, 9.8)), severe under nutrition (AOR = 8.9(2.1, 37.3)), no fish food (AOR = 2.4(1.3, 4.5)), drinking coffee (AOR = 1.6(1.0, 2.6)), moderate food insecurity (AOR = 2.5(1.4, 4.6)), and no malaria infection (AOR = 0.6(0.4, 0.9)) were statistically significant with anemia. Conclusion: The anaemia is a public health problem in this study area. Therefore, nutrition education and counselling to enhance iron supplementation, dietary diversity and a flesh diets are very essential to enhance haemoglobin levels.
Needle Arthroscopy Versus Conventional Arthroscopy in the Evaluation of Carpal Pathology: A Comparative Study
Authors: Moses Michael J. , Lorentz Nathan A. , Azad Ali , Paksima Nader 
Published: July 2024

Background: The needle scope is a less invasive intervention to evaluate carpal pathology. We hypothesize that there is no difference in the evaluation and diagnostic capability of the needle scope versus the conventional wrist arthroscope. Methods: Twenty patients indicated for wrist arthroscopy were prospectively enrolled. Prior to insertion of the 2.7-mm arthroscope, the needle scope evaluated for synovitis; cartilage damage (location and modified Outerbridge classification); integrity of the volar, scapholunate (SL), and lunotriquetral ligaments; and the triangular fibrocartilage complex (TFCC). Following needle scope evaluation, the surgeon completed a survey regarding the visualization and diagnosis. The 2.7-mm arthroscope was then inserted, and the surgeon completed the second portion of the survey. Statistical analysis was then completed to determine statistical significance. Results: Twelve patients were female (60%), and the mean age was 39.8 years (±11.8 years). Eleven patients underwent arthroscopy for TFCC pathology, 4 patients for SL tearing, and 5 patients for extensive synovitis. There was no difference between the needle scope and wrist arthroscopy diagnosis. There was no difference between radiocarpal and midcarpal visualization. Surgeon-rated ease of use and diagnostic confidence were the same between two groups. The needle scope was better able to visualize the scapho-trapezium-trapezoid and carpometacarpal joints; however, the image was of marginally decreased quality. Conclusion: In this study, there was no difference between radiocarpal or midcarpal visualization and surgeon-rated ease of use, while diagnostic confidence was the same between two groups. Level of Evidence: II (prospective cohort study)—Diagnostic