bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of hepatic arterial infusion chemotherapy and its combination strategies for advanced hepatocellular carcinoma: A network meta-analysis
Authors: Zhou Shun-An , Zhou Qing-Mei , Wu Lei , Chen Zhi-Hong , Wu Fan , Chen Zhen-Rong , Xu Lian-Qun , Gan Bi-Ling , Jin Hao-Sheng , Shi Ning 
Published: August 2024

BACKGROUND
With the rapid progress of systematic therapy for hepatocellular carcinoma (HCC), therapeutic strategies combining hepatic arterial infusion chemotherapy (HAIC) with systematic therapy arised increasing concentrations. However, there have been no systematic review comparing HAIC and its combination strategies in the first-line treatment for advanced HCC.
AIM
To investigate the efficacy and safety of HAIC and its combination therapies for advanced HCC.
METHODS
A network meta-analysis was performed by including 9 randomized controlled trails and 35 cohort studies to carry out our study. The outcomes of interest comprised overall survival (OS), progression-free survival (PFS), tumor response and adverse events. Hazard ratios (HR) and odds ratios (OR) with a 95% confidence interval (CI) were calculated and agents were ranked based on their ranking probability.
RESULTS
HAIC outperformed Sorafenib (HR = 0.55, 95%CI: 0.42-0.72; HR = 0.51, 95%CI: 0.33-0.78; OR = 2.86, 95%CI: 1.37-5.98; OR = 5.45, 95%CI: 3.57-8.30; OR = 7.15, 95%CI: 4.06-12.58; OR = 2.89, 95%CI: 1.99-4.19; OR = 0.48, 95%CI: 0.25-0.92, respectively) and transarterial chemoembolization (TACE) (HR = 0.50, 95%CI: 0.33-0.75; HR = 0.62, 95%CI: 0.39-0.98; OR = 3.08, 95%CI: 1.36-6.98; OR = 2.07, 95%CI: 1.54-2.80; OR = 3.16, 95%CI: 1.71-5.85; OR = 2.67, 95%CI: 1.59-4.50; OR = 0.16, 95%CI: 0.05-0.54, respectively) in terms of efficacy and safety. HAIC + lenvatinib + ablation, HAIC + ablation, HAIC + anti- programmed cell death 1 (PD-1), and HAIC + radiotherapy had the higher likelihood of providing better OS and PFS outcomes compared to HAIC alone. HAIC + TACE + S-1, HAIC + lenvatinib, HAIC + PD-1, HAIC + TACE, and HAIC + sorafenib had the higher likelihood of providing better partial response and objective response rate outcomes compared to HAIC. HAIC + PD-1, HAIC + TACE + S-1 and HAIC + TACE had the higher likelihood of providing better complete response and disease control rate outcomes compared to HAIC alone.
CONCLUSION
HAIC proved more effective and safer than sorafenib and TACE. Furthermore, combined with other interventions, HAIC showed improved efficacy over HAIC monotherapy according to the treatment ranking analysis.
Research status and hotspots of tight junctions and colorectal cancer: A bibliometric and visualization analysis
Authors: Li Hui-Min , Liu Yin , Hao Meng-Di , Liang Xiao-Qing , Yuan Da-Jin , Huang Wen-Bin , Li Wen-Jie , Ding Lei 
Published: August 2024

BACKGROUND
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. Over the past two decades, numerous researchers have provided important evidence regarding the role of tight junction (TJ) proteins in the occurrence and progression of CRC. The causal relationship between the presence of specific TJ proteins and the development of CRC has also been confirmed. Despite the large number of publications in this field, a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been performed.
AIM
To analyze research on TJs and CRC, summarize the field’s history and current status, and predict future research directions.
METHODS
We searched the Science Citation Index Expanded database for all literature on CRC and TJs from 2001-2023. We used bibliometrics to analyze the data of these papers, such as the authors, countries, institutions, and references. Co-authorship, co-citation, and co-occurrence analyses were the main methods of analysis. CiteSpace and VOSviewer were used to visualize the results.
RESULTS
A total of 205 studies were ultimately identified. The number of publications on this topic has steadily increased since 2007. China and the United States have made the largest contributions to this field. Anticancer Research was the most prolific journal, publishing 8 articles, while the journal Oncogene had the highest average citation rate (68.33). Professor Dhawan P was the most prolific and cited author in this field. Co-occurrence analysis of keywords revealed that “tight junction protein expression”, “colorectal cancer”, “intestinal microbiota”, and “inflammatory bowel disease” had the highest frequency of occurrence, revealing the research hotspots and trends in this field.
CONCLUSION
This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC, providing valuable research perspectives and future directions for studying the connection between the two. It is recommended to focus on emerging research hotspots, such as the correlations among intestinal microbiota, inflammatory bowel disease, TJ protein expression, and CRC.
Jejunal sarcomatoid carcinoma: A case report and review of literature
Authors: Feng Qian , Yu Wei , Feng Jing-Hui , Huang Qiao , Xiao Gui-Xiang 
Published: August 2024

BACKGROUND
Sarcomatoid carcinoma (SCA) of the jejunum is a rare and aggressive neoplasm affecting the smooth muscle cells of the jejunum. This study presents a recent case of jejunal SCA, detailing its diagnosis and treatment, thereby providing a reference for clinical practice.
CASE SUMMARY
A 65-year-old male presented to Yichang Central People's Hospital with a chief complaint of hemorrhoids. A computed tomography (CT) scan incidentally revealed multiple abnormal signals in the liver. Subsequent positron emission tomography/CT at Wuhan Union Hospital indicated malignant tumor progression, with a primary duodenal tumor and multiple metastases in the upper left abdomen. Intraoperatively, a large tumor was identified on the omentum. Histopathological and immunohistochemical analyses of the resected specimen confirmed the diagnosis of jejunal SCA. The patient received a combination therapy of sintilimab, nanoparticle albumin-bound paclitaxel, and anlotinib. Follow-up imaging demonstrated significant reduction of hepatic and peritoneal lesions. The patient has remained stable for over one year postoperatively.
CONCLUSION
This case suggests that chemotherapy, immunotherapy, plus targeted therapy may represent an optimal treatment for intestinal SCA, meriting further investigation.
Adevăr, libertate și speranță
Authors:   Theatre and Multimedia Research Institute, University of Arts, Târgu-Mureș, Dan Marcela 
Published: August 2024

Romulus Guga's plays have an openness to politics and the leitmotif of his plays is freedom, good versus evil and the affirmation of dignity. He believed that the playwright is born through the performance and dramaturgy is a collective work. Romulus Guga's plays are open to politics and the leitmotif of his plays is freedom, good versus evil and the affirmation of dignity. He believed that the playwright is born through the performance and dramaturgy is a collective work. „Hope Does not Die at Dawn” is the first play by a local Romanian author presented on the Târgu Mureș stage. Its opening at the National Theater in Târgu Mureș took place on March the 31st, 1973, on the occasion of World Theater Day. At the Piatra Neamț Youth Theater Show Festival, the most prestigious theatrical event of the era, "Hope Does not Die at Dawn” was crowned with the “Grand Prize for the show”, the “Male Performance Award” (Florin Zamfirescu), "Female Performance Award” (Lucia Boga), and "Honorary Diploma for Directing” (Dan Micu). This paper aims to analyse the tense relationship between censorship during communism, the plays, how they were staged, and the hidden language understood only by the artists and the audience. Romulus Guga’s play is set as an example of the way quality performances were met with critical acclaim in the era, despite political censorship.
Cap a una geografia líquida: Anna Murià i els camins i fluxos de la commemoració
Authors: Buffery Helena 
Published: August 2024

This article sets out to address the presence/absence of female writers in processes of commemoration of literary figures in contemporary Catalan culture, focusing on the case of Anna Murià (1904–2002). Recently included among the ten “classic” writers presented as part of the volume Women Writers in Catalan (Huerga, 2017), the process of her recovery for a possible feminine – let alone feminist – canon has been complicated by the fact that she dedicated the majority of her life, after 1939, to consolidating the “voice” of her husband, the poet Agustí Bartra, in exile in the Dominican Republic, Cuba, Mexico and the US, and after the couple’s return to Catalonia in 1970. Considering different moments of Murià’s commemorative labour and reception – from the moment of return; through the death of Bartra in 1982; to posthumous reframings after her own death in 2002 – the article explores the debates and ambivalence surrounding her significance, as a figure which, depending on the perspective of the reader, can be employed to represent: Republican memory; the continuity of exile; the experience of being a woman; feminism and feminine creativity; and/or the subordination of her own subjectivity to that of her husband and life partner, Bartra. Rather than attempting to resolve this ambivalence, this article will show how a more attentive, genealogical reading of her work enables us to contrast the inescapably patriarchal politics of monumentalizing associated with national memory cultures with the more fluid and relational ethics that characterise her own commemorative labour and writing of the self: as a call to imagine and begin to formulate alternative practices of memorialization.
Implementation of Value Engineering in Bandung Islamic University Hospital Building Construction
Authors: Salman Faruq Reza , Sri Handayani Fajar , Setiono Setiono 
Published: August 2024

Infrastructure development in Indonesia has increased sharply every year. Construction projects are starting to appear at a fairly high frequency in each region. However, in the process of project development, the quality, time, and cost aspects are not always optimal. Therefore, Value Engineering analysis is needed to get optimal results. This Value Engineering analysis is able to identify components that can be saved and determine alternatives to replace these components without reducing the quality or quality of work. The case study in this research is the Bandung Islamic University Hospital Construction Project. The Value Engineering analysis carried out on this project is a change in the work of the upper structure, such as slab, column and beam from conventional to precast concrete. In addition to Value Engineering analysis, this research also analyzed greenhouse gas emissions using Life Cycle Assessment analysis. The results showed savings of Rp 3,180,685,659.81 or 8.19% of the initial project cost. Meanwhile, the existing greenhouse gas emissions amounted to 9556.01 kgCO2e and for alternative work amounted to 72896.49 kgCO2e.
E-contract Consensus in Indonesian Contract Law
Authors: Sulistyaningrum Helena Primadianti 
Published: August 2024

Introduction: In the era of Society 5.0, the use of IT in implementing agreements in Indonesia is inevitable. The development of e-contracts, becoming increasingly necessary in society, is demanding the business world's attention. Particularly in Indonesia's Treaty Law, the concept of consensual e-contracting emerged, suggesting that even in the absence of direct meetings, parties could still realize an agreement through the e-contract. Purposes of the Research: This study aims to analyze and describe the existence of e-contract consensus in contract law in Indonesia from the point of view of contract theory. Methods of the Research: This specific type of investigation is doctrinal law research, which endeavors to uncover the truth by employing legal principles, foundational doctrines, and doctrinal law as supporting material. This work utilizes an inductive methodology, first presenting specific assertions and then drawing a general conclusion from them.Results of the Research: One of the legal prerequisites for an agreement is consensus. The study's findings indicate that legislative regulations in Indonesia have incorporated e-contract consensus into contract law. We apply Uitings theory, Verzending theory, and Ontvangs theory as agreement theories to determine the existence of e-contract consensus. The legislation contains provisions that specifically address the maintenance of electronic transactions. In general, it establishes that an electronic transaction has taken place when the parties to an electronic contract (e-contract) issue a statement of acceptance of an offer.
СПЕЦИФИКА РИТМИЧЕСКОЙ ОРГАНИЗАЦИИ ПРОЗЫ МАРИНЫ ЦВЕТАЕВОЙ
Authors: Эргашева Асаль 
Published: August 2024

Статья посвящена рассмотрению проблемы особенностей поэтики прозаических произведений Марины Цветаевой. Особое внимание уделяется ритмической специфике прозы. Предпринята попытка определить сюжетно-композиционную ритмическую структуру произведений: эссе, воспоминаний.
Effect of Aloe Vera, Wood Ash, and Indole-Butyric Acid on In-Vivo Macro Propagation of Robusta Coffee Stem Cuttings
Authors: Keimusya Rauben , Arinaitwe Byarugaba , Osiru David 
Published: August 2024

Purpose: This study investigated the influence of Aloe Vera, Wood ash and a synthetic growth hormone Indole-butyric acid (IBA) on root and shoot in the proliferation of Coffee Wilt disease-resistant (CWD-R) Robusta coffee stem cuttings.
Methodology: Stem cuttings of CWD-R Robusta coffee were treated with five levels of rooting natural substances and IBA independently and in combination. The treated cuttings were propagated in a uniform potting medium under humidity chamber conditions. Data was collected on the number of surviving cuttings, shoot and root number, and root and shoot lengths. At 90 days after planting, data on root proliferation, the number, and lengths of roots were collected and analyzed for variance (ANOVA) using GenStat 11th Edition.
Findings: The survival, root, and shoot development were significantly (p<0.05) influenced by the rooting substances applied. A combination of Aloe Vera and IBA, 0.8% IBA, and Aloe Vera gel applied alone gave the highest percentages (90, 70 and 70%, respectively) of stem cuttings that survived to form roots and shoots. A mixture of aloe Vera and IBA, 0.8% IBA, and Aloe Vera gave the highest mean number of shoots and roots per cutting; that is (8.75, 8.5, and 8.5 cm) and (13.87, 12.85 and 12.39 cm) for shoots and roots respectively. Cuttings treated with wood ash and control gave the lowest mean number of shoots and roots that formed per cutting; that is (5.25 and 4.50 cm) and (11.75 and 11.38 cm) for shoots and roots respectively.
Unique Contribution to Theory, Practice and Policy: Propagation of Coffea canephora, by stem cuttings can be adequately achieved by using Aloe Vera, IBA, or their mixture, but not with wood ash.
Budget Control on Capital Project Delivery in Samburu County Government
Authors: Lesorogol Nelson , Achimba Clement , Opondo Florence 
Published: August 2024

Purpose: This study aimed to evaluate the effects of budget control on delivery of capital project delivery in Samburu County-Kenya.
Methodology: This study examined the effect of budget control procedures on the completion of capital projects using a descriptive research design. A total of 52 employees who were department heads and routinely took part in the budgeting process, belonging to the J, K, and L job groups, comprise the research sample. To effectively represent the intricate dynamics at work and to offer insightful information about how budget control affects the efficacy and efficiency of capital project delivery within the framework of the Samburu County Government, data was provided in linear regression models.
Findings: The findings of this study can assist county governments in better understanding the factors that affect county budget management systems and performance as well as what needs to be changed to enhance the aforementioned budget performance. The findings can also be helpful to academics while looking into how budgetary control affects the provision of public services. Finally, it may offer politicians and other decision-makers new insights into the delivery of capital projects and the management of public resources. The study's results demonstrated that budget control significantly impacted capital project delivery in Samburu County, accounting for 77.3% of the variance with P ˂ 0.05.
Unique Contribution to Theory, Practice and Policy: The study investigated how capital project delivery and budget control interact using the agency theory. Kenyan county governments and legislators should tighten budget control to address issues. The primary finding of the study was that counties can accomplish their financial and quantitative objectives with the aid of budget control. Additionally, it can help the county meet its goals, identify the operating activity items in the budgets, and fortify the relevant accounting structures.
Analysis of the Uyghur Cultural Genocide
Authors: Kothari Nikhil 
Published: August 2024

Despite the news coverage about the Uyghurs, there is limited information about historical events that shaped the Uyghur cultural genocide and how the crisis fits into the broader scope of ethnic minorities in China. This paper examines the role of Han Chinese ethnocentrism in the Chinese government's treatment of the Uyghurs. The Uyghurs have experienced an eradication of their way of life and evaluation of evidence from personal correspondence, diaries, speeches, and other primary and secondary sources, assists in deepening understanding of the genocide. Although the oppression is rooted in key events in the twentieth century, it was challenging to find primary sources due to CCP censorship and many documents written in Mandarin. Nevertheless, extensive research led to useful sources for analysis. The Uyghur cultural genocide is an important topic to study as it is a human rights crisis that continues to unfold today.
Urban stormwater ponds can support dragonfly reproduction akin to natural ponds
Authors: Perron Mary Ann C. , Bried Jason T. , Richmond Isabella C. , Charette Cristina , Pick Frances R. 
Published: August 2024

Stormwater ponds are constructed to receive urban runoff and regulate flooding of built areas. As a result, they can be more stressful habitats for aquatic organisms than natural ponds. Adult dragonflies are known to frequent stormwater management ponds in cities, but whether they successfully reproduce in these artificial systems is not clear. This study compared the reproductive potential of dragonflies in stormwater ponds across a temperate metropolitan area through weekly collections of exuviae at stormwater ponds and natural (reference) ponds. We hypothesized that stormwater ponds were poor habitats for dragonfly reproduction (in comparison to natural ponds) because of the typically negative effects of urbanization on wildlife. With respect to dragonfly reproduction, we therefore predicted: (1) lower breeding recruitment, (2) fewer habitat specialists, and (3) greater homogenization of breeding assemblages at stormwater ponds. However, we did not find a significant difference in the number of species and abundance of exuviae between stormwater and natural ponds. Stormwater ponds also supported similar numbers of habitat specialists as natural ponds. Furthermore, we did not find evidence of greater biotic homogenization across stormwater ponds as species composition was similar between both pond types. These results indicate that stormwater ponds can support the reproductive success of a diverse community of dragonflies.
Reflexões em torno da cidade e do urbano
Authors: Silva José Borzacchiello da 
Published: August 2024

O texto discute a cidade e o processo de urbanização decorrente da incorporação de atividades desenvolvidas a partir de inovações no campo da ciência e tecnologia resultantes da Revolução Industrial, na segunda metade do século XVIII. Os primeiros estabelecimentos fabris e trechos de ferrovia foram construídos na Inglaterra e, posteriormente, noutras regiões da Europa. A propagação dessas inovações deu-se de forma rápida, chegando a vários países. Entretanto, a distribuição dessas inovações na cidade não se deu e não se dá de forma homogênea, produzindo assim vários territórios marcados pela desigualdade. Mesmo nas sociedades tidas como socialmente mais avançadas, as densidades técnicas e inovadoras acontecem de forma diferente nos espaços. Uma multiplicidade de formas e de arranjos caracteriza as cidades. Essas variações hierárquicas de tamanho e centralidade tem se tornado cada vez mais complexas, o que dificulta, muitas vezes, uma leitura aperfeiçoada da cidade, a qual facilitaria a sua análise. O texto também destaca a maneira como se deu a urbanização no Brasil.
WINDOWS ОПЕРАЦИЯЛЫҚ ЖҮЙЕСІНДЕГІ ҚАТЕЛІКТЕРДІ ЗЕРТТЕУ ЖӘНЕ ТАЛДАУ
Authors: Ташенова Жулдыз , Нурлыбаева Эльмира , Абдугулова Жанат , Аманжолова Ширин 
Published: August 2024

Бұл мақалада 2020 жылы шыққан Windows 10 операциялық жүйеде (ОЖ) туындайтын қателіктер мен олардын алдын алу жолдары мен әдістеріне зерттеу жүргізу болып табылады. Windows операциялық жүйесінде туындайтын қателіктерді зерттеп, оларды түзеу үшін ұсыныстар жасау осы мақалада зерттеледі. Операциялық жүйе құру принциптері, қолданыстағы операциялық жүйелерде жиі кездесетін қателіктерді талдау жұмыстарын жүргізуге арналған. Windows операциялық жүйесін басқа жүйелермен саластыру және Windows операциялық жүйесінде туындайтын қателіктерді және туындау себептерін анықтау көрсетілген. Windows операциялық жүйесінде туындайтын қателіктерді жою бойынша ұсыныстар құра отырып оларды алдын алу болып табылады. Windows операциялық жүйесінде туындайтын қателіктерді зерттеу және оларды жою жолдары бойынша ұсыныстар болашақта операциялық жүйенің жаңа нұсқасында қателіктерді алдын ала жою мәселелері қарастырылды. Және де, 2020 жылы шыққан Windows 10 операциялық жүйесінде туындайтын қателіктер мен олардын алдын алу жолдары мен әдістеріне зерттеу жүргізіледі. Түзетуді қажет ететін өзекті қателіктің бірі кәсіпорындардағы домен контроллерлері Kerberos түпнұсқалығын тексеру және Kerberos билетін жаңарту мәселелеріне тап болуы мүмкіндігі болып табылады. Операциялық жүйе құру принциптеріне шолу жасалынады. Қолданыстағы операциялық жүйелерде жиі кездесетін қателіктер талданады. Windows операциялық жүйесін басқа жүйелермен саластыру жүргізіледі. Windows операциялық жүйесінде туындайтын қателіктерді және туындау себептерін анықталады. Windows операциялық жүйесінде туындайтын қателіктерді жою бойынша ұсыныстар құрылады. Сонымен қатар, windows 10 операциялық жүйесі кіріктірілген қауіпсіздік саясатын баптау бойынша ұсыныстар қосымша ақпарат ретінде келітірілді.
АКУСТИКАДАҒЫ НЕМЕСЕ ЭЛЕКТРОДИНАМИКАДАҒЫ ГЕЛЬМГОЛЬЦ ТЕҢДЕУІН ЗЕРТТЕУ ҮШІН ПАРАЛЛЕЛЬ ЕСЕПТЕУЛЕРДІ ҚОЛДАНУ
Authors: Ауелбеков Омирлан , Есентаев Кайрат , Маметжанова Назгуль 
Published: August 2024

Бұл мақалада Гельмгольц акустика немесе электродинамика мәселелерін талдау үшін параллель программалауды қолдануды қарастыратын боламыз. Гельмгольц теңдеулері акустикада, оптикада және басқа салаларда маңызды рөл атқарады, бұл толқындардың таралуын модельдеуге мүмкіндік береді. Электродинамика мәселелері электромагниттік өрістер мен толқындық процестерді талдау үшін инженерияда, электроникада және басқа да көптеген салаларда кеңінен қолданылады. Бұл мақала осы есептерді шешудің тиімділігін жақсарту үшін параллельді программалауды қолдануға бағытталған. Гельмгольц теңдеуінің акустика немесе электродинамика есептерін шешудің қолданыстағы әдістерін қарастыруды, сондай-ақ біз әзірлеген параллель алгоритмдер мен шешімдердің өнімділігі мен дәлдігін жақсартуға бағытталған эксперименттердің нәтижелерін ұсынуды жоспарлап отырмыз.