bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to Breast and Colorectal Cancer Survivorship Care: Perceptions of Primary Care Physicians and Medical Oncologists in the United States
Authors: Virgo Katherine S. , Lerro Catherine C. , Klabunde Carrie N. , Earle Craig , Ganz Patricia A. 
Published: May 2013

Purpose High-quality, well-coordinated cancer survivorship care is needed yet barriers remain owing to fragmentation in the United States health care system. This article is a nationwide survey of barriers perceived by primary care physicians (PCPs) and medical oncologists (MOs) regarding breast and colorectal cancer survivorship care beyond 5 years after treatment. Methods The Survey of Physician Attitudes Regarding the Care of Cancer Survivors was mailed out in 2009 to a nationally-representative sample (n = 3,596) of US PCPs and MOs. Ten physician-perceived cancer survivorship care barriers/concerns were compared between the two provider types. Using weighted multinomial logistic regression, we modeled each barrier, adjusting for physician demographics, reimbursement, training, and practice characteristics. Results We received responses from 2,202 physicians (1,072 PCPs; 1,130 MOs; 65.1% cooperation rate). In adjusted patient-related barriers models, MOs were more likely than PCPs to report patient language barriers (odds ratio, [OR], 1.72; 95% CI, 1.22 to 2.42), insurance restrictions impeding test/treatment use (OR, 1.42; 95% CI, 1.03 to 1.96), and patients requesting more aggressive testing (OR, 4.08; 95% CI, 2.73 to 6.10). In adjusted physician-related barriers models, PCPs were more likely to report inadequate training (OR, 3.06; 95% CI, 2.03 to 4.61) and ordering additional tests/treatments because of malpractice concerns (OR, 1.87; 95% CI, 1.20 to 2.93). MOs were more likely to report uncertainty regarding general preventive care responsibility (often/always: OR, 1.97; 95% CI, 1.13 to 3.43; sometimes: OR, 2.16; 95% CI, 1.60 to 2.93). Conclusion MOs and PCPs perceive different cancer follow-up care barriers/concerns to be problematic. Resolving inadequate training, malpractice-driven test ordering, and preventive-care responsibility concerns may require continuing education, explicit guidelines, and survivorship care plans. Reviewing care plans with survivors may also reduce patients' requests for unnecessary testing.
Second Malignant Neoplasms After Treatment of Childhood Acute Lymphoblastic Leukemia
Authors: Schmiegelow Kjeld , Levinsen Mette Frandsen , Attarbaschi Andishe , Baruchel Andre , Devidas Meenakshi , Escherich Gabriele , Gibson Brenda , Heydrich Christiane , Horibe Keizo , Ishida Yasushi , Liang Der-Cherng , Locatelli Franco , Michel Gérard , Pieters Rob , Piette Caroline , Pui Ching-Hon , Raimondi Susana , Silverman Lewis , Stanulla Martin , Stark Batia , Winick Naomi , Valsecchi Maria Grazia 
Published: May 2013

PurposeSecond malignant neoplasms (SMNs) after diagnosis of childhood acute lymphoblastic leukemia (ALL) are rare events.Patients and MethodsWe analyzed data on risk factors and outcomes of 642 children with SMNs occurring after treatment for ALL from 18 collaborative study groups between 1980 and 2007.ResultsAcute myeloid leukemia (AML; n = 186), myelodysplastic syndrome (MDS; n = 69), and nonmeningioma brain tumor (n = 116) were the most common types of SMNs and had the poorest outcome (5-year survival rate, 18.1% ± 2.9%, 31.1% ± 6.2%, and 18.3% ± 3.8%, respectively). Five-year survival estimates for AML were 11.2% ± 2.9% for 125 patients diagnosed before 2000 and 34.1% ± 6.3% for 61 patients diagnosed after 2000 (P < .001); 5-year survival estimates for MDS were 17.1% ± 6.4% (n = 36) and 48.2% ± 10.6% (n = 33; P = .005). Allogeneic stem-cell transplantation failed to improve outcome of secondary myeloid malignancies after adjusting for waiting time to transplantation. Five-year survival rates were above 90% for patients with meningioma, Hodgkin lymphoma, thyroid carcinoma, basal cell carcinoma, and parotid gland tumor, and 68.5% ± 6.4% for those with non-Hodgkin lymphoma. Eighty-nine percent of patients with brain tumors had received cranial irradiation. Solid tumors were associated with cyclophosphamide exposure, and myeloid malignancy was associated with topoisomerase II inhibitors and starting doses of methotrexate of at least 25 mg/m2per week and mercaptopurine of at least 75 mg/m2per day. Myeloid malignancies with monosomy 7/5q− were associated with high hyperdiploid ALL karyotypes, whereas 11q23/MLL-rearranged AML or MDS was associated with ALL harboring translocations of t(9;22), t(4;11), t(1;19), and t(12;21) (P = .03).ConclusionSMNs, except for brain tumors, AML, and MDS, have outcomes similar to their primary counterparts.
Should a Woman Age 70 to 80 Years Receive Radiation After Breast-Conserving Surgery?
Authors: Hepel Jaroslaw T. , Wazer David E. 
Published: May 2013

Case 1: A 72-year-old woman presents with a palpable mass detected during yearly physical examination by her primary care physician. She has controlled hypertension and remains active, playing tennis three times a week. Physical examination reveals a 1.5 cm mass in the upper outer quadrant of the left breast with no palpable axillary lymphadenopathy. Diagnostic imaging reveals a suspicious mass, and core biopsy confirms invasive ductal carcinoma (IDC) that is estrogen receptor moderately positive (60%), progesterone receptor negative and Her2-neu that is not overexpressed. She undergoes a wide local excision and sentinel node biopsy. Pathology reveals a 1.5 cm IDC that is high grade without lymphovascular invasion (LVI). The margins are negative with the closest laterally at 2 mm. One sentinel node is negative for metastasis. Case 2: A 72-year-old woman presents with an abnormal screening mammogram that shows a small area of architectural distortion in the upper outer quadrant of the left breast ( Fig 1 ). She is a former smoker with mild chronic obstructive pulmonary disease and has mild to moderately symptomatic osteoarthritis managed with a nonsteroidal anti-inflammatory agent. She remains active and independent. Physical examination reveals neither palpable breast mass nor axillary lymphadenopathy. Diagnostic ultrasound confirms a 1.8 cm mass, and core biopsy reveals IDC that is estrogen and progesterone receptor strongly positive (> 90%) and Her2-neu that is not overexpressed. She undergoes a wide local excision and sentinel node biopsy. Pathology reveals a 1.9 cm IDC that is low grade. The margins are widely negative at > 5 mm and there is no LVI. One sentinel node is negative for metastasis.
Sally’s question and a conjecture of shimoda
Authors: Goto Shiro , O’carroll Liam , Planas-Vilanova Francesc 
Published: May 2013

AbstractIn 2007, Shimoda, in connection with a long-standing question of Sally, asked whether a Noetherian local ring, such that all its prime ideals different from the maximal ideal are complete intersections, has Krull dimension at most 2. In this paper, having reduced the conjecture to the case of dimension 3, if the ring is regular and local of dimension 3, we explicitly describe a family of prime ideals of height 2 minimally generated by three elements. Weakening the hypothesis of regularity, we find that, to achieve the same end, we need to add extra hypotheses, such as completeness, infiniteness of the residue field, and the multiplicity of the ring being at most 3. In the second part of the paper, we turn our attention to the category of standard graded algebras. A geometrical approach via a double use of a Bertini theorem, together with a result of Simis, Ulrich, and Vasconcelos, allows us to obtain a definitive answer in this setting. Finally, by adapting work of Miller on prime Bourbaki ideals in local rings, we detail some more technical results concerning the existence in standard graded algebras of homogeneous prime ideals with an (as it were) excessive number of generators.
Induced pluripotent stem cells derived from rabbits exhibit some characteristics of naïve pluripotency
Authors: Osteil Pierre , Tapponnier Yann , Markossian Suzy , Godet Murielle , Schmaltz-Panneau Barbara , Jouneau Luc , Cabau Cédric , Joly Thierry , Blachère Thierry , Gócza Elen , Bernat Agnieszka , Yerle Martine , Acloque Hervé , Hidot Sullivan , Bosze Zsuzsanna , Duranthon Véronique , Savatier Pierre , Afanassieff Marielle 
Published: May 2013

Summary
Not much is known about the molecular and functional features of pluripotent stem cells (PSCs) in rabbits. To address this, we derived and characterized 2 types of rabbit PSCs from the same breed of New Zealand White rabbits: 4 lines of embryonic stem cells (rbESCs), and 3 lines of induced PSCs (rbiPSCs) that were obtained by reprogramming adult skin fibroblasts. All cell lines required fibroblast growth factor 2 for their growth and proliferation. All rbESC lines showed molecular and functional properties typically associated with primed pluripotency. The cell cycle of rbESCs had a prolonged G1 phase and a DNA damage checkpoint before entry into the S phase, which are the 2 features typically associated with the somatic cell cycle. In contrast, the rbiPSC lines exhibited some characteristics of naïve pluripotency, including resistance to single-cell dissociation by trypsin, robust activity of the distal enhancer of the mouse Oct4 gene, and expression of naïve pluripotency-specific genes, as defined in rodents. According to gene expression profiles, rbiPSCs were closer to the rabbit inner cell mass (ICM) than rbESCs. Furthermore, rbiPSCs were capable of colonizing the ICM after aggregation with morulas. Therefore, we propose that rbiPSCs self-renew in an intermediate state between naïve and primed pluripotency, which represents a key step toward the generation of bona fide naïve PSC lines in rabbits.
Crystal structure of 2-(4-methylphenyl)-2-oxo-1-(phenyliodonio)-1-(triphenylarsonio)ethanid tetrafluoroborate solved from X-ray powder data
Authors: Mironov Andrei V. , Chernyshev Vladimir V. , Matveeva Elena D. , Podrugina Tatyana A. , Alferova Vera A. , Gleiter Rolf , Zefirov Nikolai S. 
Published: May 2013

Abstract
The crystal structure of 2-(4-methylphenyl)-2-oxo-1-(phenyliodonio)-1-(triphenylarsonio)ethanid tetrafluoroborate, C33H27AsIO+BF4
–, was solved and refined from laboratory X-ray powder diffraction data in combination with a DFT calculation (CoK
α1, a=24.427(2) Å, b = 13.3412(18) Å, c=22.399(2) Å, β = 119.49(2)°, S.G. C2/c, R
p/R
wp = 0.030/0.039). The main features of the C33H27AsIO+BF4
– structure are similar to those reported previously for arsenium and phosphorous organic compounds. The distinctive features are short I … O and I … F (2.743(19) and 2.916(17) Å, respectively) intermolecular contacts, also observed previously in the same type of compound, refined from single crystal data.
Factors Affecting Caregivers’ Use of Antibiotics Available Without a Prescription in Peru
Authors: Ecker Lucie , Ochoa Theresa J. , Vargas Martha , Del Valle Luis J , Ruiz Joaquim 
Published: May 2013

OBJECTIVE:To determine factors that affect caregivers’ decisions about antibiotic use in children in settings where antibiotics are available without prescription.METHODS:In a house-to-house survey, 1200 caregivers in 3 periurban districts of Lima, Peru, were asked about antibiotic use in young children.RESULTS:In this sample, 87.2% of children aged &lt;5 years had received an antibiotic drug in their lives; 70.3% had received antibiotics before 1 year of age, and 98.8% of those had been prescribed by a physician. Given hypothetical cases of common cold and nondysenteric diarrhea, caregivers would seek medical advice in 76.4% and 87.1%, respectively, and 84.6% of caregivers said they respected medical decisions even if an antibiotic was not prescribed. Caregivers with high school–level education accepted 80% more medical decisions of not using an antibiotic and used fewer pharmacist-recommended antibiotics. For each additional year of life, the risk of self-medicated antibiotic use and the use of pharmacist-recommended antibiotics increased in 30%. (OR: 1.3, 95% CI: 1.1–1.4, P = .001 and OR: 1.3, 95% CI: 1.2–1.5, P &lt; .001, respectively). Caregivers respected a medical decision of not prescribing an antibiotic 5 times more when physicians had explained the reason for their advice (OR: 5.0, 95% CI: 3.2–7.8, P &lt; .001).CONCLUSIONS:Prescribed antibiotic use in these young children is common. Even if they are available without prescription, caregivers usually comply with medical advice and follow physicians’ recommendations when antibiotics are not prescribed. Improving physician prescribing habits could reduce irrational antibiotic use, decreasing future caregiver-driven misuse.
Race and Acute Abdominal Pain in a Pediatric Emergency Department
Authors: Caperell Kerry , Pitetti Raymond , Cross Keith P. 
Published: May 2013

OBJECTIVE:To investigate the demographic and clinical factors of children who present to the pediatric emergency department (ED) with abdominal pain and their outcomes.METHODS:A review of the electronic medical record of patients 1 to 18 years old, who presented to the Children’s Hospital of Pittsburgh ED with a complaint of abdominal pain over the course of 2 years, was conducted. Demographic and clinical characteristics, as well as visit outcomes, were reviewed. Subjects were grouped by age, race, and gender. Results of evaluation, treatment, and clinical outcomes were compared between groups by using multivariate analysis and recursive partitioning.RESULTS:There were 9424 patient visits during the study period that met inclusion and exclusion criteria. Female gender comprised 61% of African American children compared with 52% of white children. Insurance was characterized as private for 75% of white and 37% of African American children. A diagnosis of appendicitis was present in 1.9% of African American children and 5.1% of white children. Older children were more likely to be admitted and have an operation associated with their ED visit. Appendicitis was uncommon in younger children. Constipation was commonly diagnosed. Multivariate analysis by diagnosis as well as recursive partitioning analysis did not reflect any racial differences in evaluation, treatment, or outcome.CONCLUSIONS:Constipation is the most common diagnosis in children presenting with abdominal pain. Our data demonstrate that no racial differences exist in the evaluation, treatment, and disposition of children with abdominal pain.
Usefulness of Routine Head Ultrasound Scans Before Surgery for Congenital Heart Disease
Authors: Rios Danielle R. , Welty Stephen E. , Gunn Julia K. , Beca John , Minard Charles G. , Goldsworthy Michelle , Coleman Lee , Hunter Jill V. , Andropoulos Dean B. , Shekerdemian Lara S. 
Published: May 2013

OBJECTIVE:The purpose of this study was to assess the utility of preoperative head ultrasound scan (HUS) in a cohort of newborns also undergoing preoperative MRI as part of a prospective research study of brain injury in infants having surgery for congenital heart disease (CHD).METHODS:A total of 167 infants diagnosed with CHD were included in this 3-center study. None of the patients had clinical signs or symptoms of preoperative brain injury, and all patients received both HUS and brain MRI before undergoing surgical intervention. HUS and MRI results were reported by experienced neuroradiologists who were blinded to any specific clinical details of the study participants. The findings of the individual imaging modes were compared to evaluate for the presence of brain injury.RESULTS:Preoperative brain injury was present on HUS in 5 infants (3%) and on MRI in 44 infants (26%) (P &lt; .001). Four of the HUS showed intraventricular hemorrhage not seen on MRI, suggesting false-positive results, and the fifth showed periventricular leukomalacia. The predominant MRI abnormality was white matter injury (n = 32). Other findings included infarct (n = 16) and hemorrhage (n = 5).CONCLUSIONS:Preoperative brain injury on MRI was present in 26% of infants with CHD, but only 3% had any evidence of brain injury on HUS. Among positive HUS, 80% were false-positive results. Our findings suggest that routine HUS is not indicated in asymptomatic term or near-term neonates undergoing surgery for CHD, and MRI may be a preferable tool when the assessment of these infants is warranted.
Tracking System, Failure Analysis and Reuse Program To Optimize Usage of Power Cable in Electrical Submersible Pumping Systems
Authors: Rubiano E.. , Vargas H.. , Martin J. L. 
Published: May 2013

Abstract
In an electrical submersible pumping system, power cable has a big impact in cost and performance; reuse procedures are established based on electrical test only, not based either on run life of the cable or number of running of the system. In Llanos Norte field in Colombia, OXY started a process to reuse power cable as an optimization cost process with good results, having in mind motor amperage, electrical test results, number of runnings, conductor size, and some other important variables which affect power cable performance.
As a second phase of optimization, failure analysis of cable presented a main issue to solve, because it is not easy to track power cable failures due to sometimes the cable used becomes spliced in many parts. Also, if the cable is reused adds an additional difficulty to the process; so, tracking is a key factor for success.
This paper contains successful story of tracking system, failure analysis and reuse program in Caño Limón as an optimization process to improve cost without affecting electrical submersible pumping systems run life and performance, including lessons learned and good practices.
Design of a Laboratory for Intermittent Gas-Lift and Study of the Dynamic Behavior of Its Components
Authors: Lara Ismael Orlando , Bordalo Sergio N. 
Published: May 2013

AbstractDespite the advances achieved so far, some important aspects of the operation of the conventional intermittent gas-lift (IGL) remain unexplored or poorly studied, as for instance, the concurrency of cycle stages, as presented by Carvalho (2004), or the stability of cycles due to motor valve timing and adjustment of the gas-lift valve. At the same time, the Zadson pneumatic pump (ZPP) has presented good results in Brazilian fields, motivating studies to develop computational simulators for the design of this method. In the course of the present work, a physical simulator was built for the IGL and ZPP, to validate numerical simulators proposed by previous authors. The laboratory apparatus consists of three operational sets, the first set represents the well-reservoir coupling, the second set is the injection system of compressed gas and the third set is a collection of columns of production of the conventional IGL and ZPP. For measurement, there are pressure transducers located at various points of the laboratory apparatus and tanks for measuring the produced volume. The system of data acquisition and actuation of the gas-lift and motor valves are controlled by a microcontroller board. Tests were performed by changing the operating variables. As conclusions of the study the concurrent stages during the IGL cycle were identified, the fallback was rated for various operating conditions, the stability of the IGL cycles was studied, and an operating map of the conditions of a stable IGL cycle was drawn. In addition, three operating modes of the ZPP were tested.
Progressing Cavity Pumps In Light Oil: Successfully Expanding the Application Envelope Through Best Practices and Lessons Learnt
Authors: Jahn Sheldon , Baldwin Brett 
Published: May 2013

Abstract
The Progressing Cavity Pump (PCP) applications continue to expand from heavy and medium into light oil applications. The benefits include lower capital cost, less visual impact, smaller footprint and decreased operational costs primarily as a result of the high mechanical efficiency of a PCP. The difference between premature failure and long-term success can be minimized by following best practices and lessons learnt from 20 years of experience evaluating thousands of wells. Light oil usually has a high percentage of Mono-Aromatics of which the most common are Benzene, Toluene, and Xylene (BTX). The molecular structure of BTX enable it to attack or attach onto the elastomer, causing aggressive swelling and softening. Light oil is usually found at deeper, warmer reservoirs causing the BTX to be more active and aggressive while also reducing the mechanical strength of the elastomer. H2S and CO2 can also be associated with light oil and have adverse effects on the elastomer. This paper will discuss how to gather important data, sort information, select equipment and provide operational guidelines to improve the overall success of PCP’s in light oil.
Improving the Reliability and Maintenance Costs of Hydraulically Actuated Sucker Rod Pumping Systems
Authors: Phillips W.. , Mehegan L.. , Hernandez J.. 
Published: May 2013

AbstractHydraulically actuated sucker rod pumps have been around since the 1940’s but have not received a widespread adoption or acceptance on the order of beam pumps, ESP’s or PCP’s. This is in no small part, due to a reputation of high maintenance costs and frequent failures. Innovations in hydraulically actuated sucker rod pumps, with a keen insight for the oilfield environment, have helped improve reliability and reduce maintenance costs. Among these improvements are the elimination of persistent external hydraulic leaks, a long-stroke capability, and a simplified control system. The instrumentation and control of the hydro-mechanical system is accomplished with an innovative method for determining both polished rod position and load based solely on the hydraulic fluid dynamics. This eliminates any sensors, or points of failure, at the wellhead. Vast improvements in control and data acquisition have greatly reduced the failure rates of hydraulic sucker rod pumping systems by automatically responding to adverse conditions. By allowing operators to remotely interact and troubleshoot the system, a finer grained level of optimization can be achieved by closely matching the wells inflow to the production rate. In some down-hole failure cases, such as a stuck pump, a unique advantage of a hydraulic system allows the operator to attempt unsticking the pump by overloading the polished rod. Although this procedure is not always successful, it does provide a last resort that may save the cost of pulling the well. This procedure is unique to a hydraulic system because there are no structural or reducer load limitations beyond that of the rod-string capacity. The long-stroke improves down-hole equipment runtimes by distributing the wear over a larger surface and by reducing the cyclic fatigue on the rod-string. While the hydraulically actuated sucker rod pump is not appropriate for every well, it does offer significant advantages in those wells where it is suitable. These advantages include long-stroke capability, remote optimization, and safe operation in terms of no external moving parts. The complete system is simple, cost effective, and portable, making it ideal for both permanent and trial installations.
Experimental Study of Centrifugal Pump Handling Viscous Fluid and Two-Phase Flow
Authors: Paternost G. M. , Bannwart A. C. , Estevam V.. 
Published: May 2013

AbstractThis paper presents an experimental study about the performance of a centrifugal pump as a function of the liquid viscosity and intake free gas fraction. The first part evaluates a pump performance map proposed by Tulsa University Artificial Lift Projects (TUALP) for single-phase flow using dimensionless numbers, which considers the fluid properties, flow rate, rotational speed and pump head for a generic centrifugal pump. The second part analyses the pump performance parameters under different liquid viscosities and free gas fractions, proposes a modification in the TUALP procedure based on well-know dimensionless numbers, and suggests an extension of the analysis to incorporate the effect of the free gas fraction on the pump performance.