bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cooperative nuclear action of RNA‐binding proteins PSF and G3BP2 to sustain neuronal cell viability is decreased in aging and dementia
Authors: Takayama Ken‐ichi , Suzuki Takashi , Sato Kaoru , Saito Yuko , Inoue Satoshi 
Published: August 2024

AbstractDysfunctional RNA‐binding proteins (RBPs) have been implicated in several geriatric diseases, including Alzheimer's disease (AD). However, little is known about the nuclear molecular actions and cooperative functions mediated by RBPs that affect gene regulation in sporadic AD or aging. In the present study, we investigated aging‐ and AD‐associated changes in the expression of PSF and G3BP2, which are representative RBPs associated with sex hormone activity. We determined that both PSF and G3BP2 levels were decreased in aged brains compared to young brains of mice. RNA sequencing (RNA‐seq) analysis of human neuronal cells has shown that PSF is responsible for neuron‐specific functions and sustains cell viability. In addition, we showed that PSF interacted with G3BP2 in the nucleus and stress granules (SGs) at the protein level. Moreover, PSF–mediated gene regulation at the RNA level correlated with G3BP2. Interestingly, PSF and G3BP2 target genes are associated with AD development. Mechanistically, quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) analysis demonstrated that the interaction of RBPs with the pre‐mRNA of target genes enhanced post‐transcriptional mRNA stability, suggesting a possible role for these RBPs in preserving neuronal cell viability. Notably, in the brains of patients with sporadic AD, decreased expression of PSF and G3BP2 in neurons was observed compared to non‐AD patients. Overall, our findings suggest that the cooperative action of PSF and G3BP2 in the nucleus is important for preventing aging and AD development.
Benefit delayed immunosenescence by regulating CD4+T cells: A promising therapeutic target for aging‐related diseases
Authors: Xia Tingting , Zhou Ying , An Jiayao , Cui Zhi , Zhong Xinqin , Cui Tianyi , Lv Bin , Zhao Xin , Gao Xiumei 
Published: August 2024

AbstractCD4+T cells play a notable role in immune protection at different stages of life. During aging, the interaction between the body's internal and external environment and CD4+T cells results in a series of changes in the CD4+T cells pool making it involved in immunosenescence. Many studies have extensively examined the subsets and functionality of CD4+T cells within the immune system, highlighted their pivotal role in disease pathogenesis, progression, and therapeutic interventions. However, the underlying mechanism of CD4+T cells senescence and its intricate association with diseases remains to be elucidated and comprehensively understood. By summarizing the immunosenescent progress and network of CD4+T cell subsets, we reveal the crucial role of CD4+T cells in the occurrence and development of age‐related diseases. Furthermore, we provide new insights and theoretical foundations for diseases targeting CD4+T cell subsets aging as a treatment focus, offering novel approaches for therapy, especially in infections, cancers, autoimmune diseases, and other diseases in the elderly.
The effect of materialism on unethical behaviour: The mediating role of self‐control
Authors: Yue Lei , Zeng Xiangli , Li Jing 
Published: August 2024

AbstractSelf‐enhancement values (power, achievement, and hedonism) have been found to be important predictors of ethical behaviour; however, the link between materialism (also a kind of self‐enhancement value) and unethical behaviour and its underlying mechanisms have received limited attention from researchers. The present research examines the effect of materialism on unethical behaviour and the mediating role of self‐control across five multi‐method studies with Chinese samples. Using Chinese data from the Sixth World Values Survey, we confirmed that materialism was positively related to a variety of unethical behaviours such as fare evasion, theft, tax evasion, bribery, domestic violence, and violence against others (Study 1). In follow‐up experiments, priming materialism increased unethical behaviour (Studies 2 and 3). Moreover, through a questionnaire survey, we found that self‐control played a mediating role between materialism and unethical behaviour in specific social contexts (Study 4). Finally, the manipulation of high materialists' self‐control reduced their unethical behaviour, further verifying the mediating role of self‐control (Study 5). Our findings indicate that materialists tend to have lower levels of self‐control, thus they are more likely to engage in unethical behaviours. This research supports the hot/cool system model of self‐control and deepens our understanding of how materialism might lead to unethical behaviour.
A meta‐analysis of perfusion parameters affecting weight gain in ex vivo perfusion
Authors: Marlar Riley , Abbas Fuad , Obeid Rommy , Frisbie Sean , Ghazoul Adam , Rezaee Ava , Sims Jack , Rampazzo Antonio , Bassiri Gharb Bahar 
Published: August 2024

AbstractBackgroundEx vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize that there is a significant relationship between specific parameters during EVMP and perfusion outcomes.MethodsA meta‐analysis of literature was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) Statement. The search encompassed articles published before July 25, 2023. PubMed, Embase, and CENTRAL databases were screened using search terms “ex‐vivo,” “ex‐situ,” “machine,” and “perfusion.” Weight gain, an indicator of organ viability, was chosen to compare outcomes. Extracted variables included perfused organ, warm and cold ischemia time before perfusion, perfusion duration, perfusate flow, pressure, temperature, perfusate composition (presence of cellular or acellular oxygen carrier, colloids, and other supplements) and percent weight change. Data were analyzed using SPSS statistical software.ResultsOverall, 44 articles were included. Red blood cell‐based perfusates resulted in significantly lower weight gain compared to acellular perfusates without oxygen carriers (11.3% vs. 27.0%, p < 0.001). Hemoglobin‐based oxygen carriers resulted in significantly lower weight gain compared to acellular perfusates (16.5% vs. 27%, p = 0.006). Normothermic perfusion led to the least weight gain (14.6%), significantly different from hypothermic (24.3%) and subnormothermic (25.0%) conditions (p < 0.001), with no significant difference between hypothermic and subnormothermic groups (24.3% vs. 25.0%, p = 0.952). There was a positive correlation between flow rate and weight gain (ß = 13.1, R = 0.390, p < 0.001).ConclusionsOxygen carriers, low flow rates, and normothermic perfusate temperature appear to improve outcomes in EVMP. These findings offer opportunities for improving organ transplantation outcomes.
Dicloxacillin is an inducer of intestinal P‐glycoprotein but neither dicloxacillin nor flucloxacillin increases the risk of stroke/systemic embolism in direct oral anticoagulant users
Authors: Iversen Ditte B. , Dunvald Ann‐Cathrine Dalgård , Ernst Martin Thomsen , Abtahi Shahab , Souverein Patrick , Klungel Olaf , Jeppesen Glenn Brøde , Nielsen Flemming , Brøsen Kim , Hammer Helen S. , Pötz Oliver , Damkier Per , Järvinen Erkka , Pottegård Anton , Stage Tore B. 
Published: August 2024

AbstractAimWe aimed to assess if dicloxacillin/flucloxacillin reduces the therapeutic efficacy of direct oral anticoagulants (DOACs) and the underlying molecular mechanism.MethodsIn a randomized, crossover study, we assessed whether dicloxacillin reduces oral absorption of drugs through P‐glycoprotein (P‐gp) during 10 and 28 days of treatment. To study the impact of dicloxacillin/flucloxacillin on intestinal and hepatic expression of P‐gp in vitro, we usd LS174T cells and 3D spheroids of primary human hepatocytes. Finally, we used nationwide Danish health registries and the UK's Clinical Practice Research Datalink to estimate hazard ratios (HRs) for the risk of stroke and systemic embolism following dicloxacillin/flucloxacillin exposure among DOAC users, using phenoxymethylpenicillin and amoxicillin as active comparators.ResultsDicloxacillin reduced the area under the curve of dabigatran to a geometric mean ratio 10 days of 0.67 (95% confidence interval [CI]: 0.42–1.1) and geometric mean ratio 28 days of 0.72 (95% CI: 0.39–1.4), suggesting reduced oral absorption via increased P‐gp expression. In vitro, dicloxacillin raised P‐gp expression in both intestinal and liver cells, while flucloxacillin only affected liver cells. In the pharmacoepidemiologic study, dicloxacillin and flucloxacillin were not associated with increased risk of stroke/systemic embolism (dicloxacillin vs. phenoxymethylpenicillin HR: 0.93, 95% CI: 0.72–1.2; flucloxacillin vs. amoxicillin HR: 0.89, 95% CI: 0.51–1.5).ConclusionsDicloxacillin increases expression of intestinal P‐gp, leading to reduced oral absorption of dabigatran. However, concomitant use of dicloxacillin/flucloxacillin was not associated with stroke and systemic embolism among DOAC users, suggesting no clinical impact from the drug–drug interaction between dicloxacillin/flucloxacillin and DOACs.
ESG and overcapacity governance evidence from Chinese listed firms
Authors: Ou Dingyu , Hou Siyao , Zhou Fenfang 
Published: August 2024

AbstractThis research examines how firms' environmental, social and governance (ESG) performance impacts their capacity utilisation using data from listed firms in China from 2009 to 2022. We find that firms' ESG performance significantly elevates their capacity utilisation with an inverted U‐shaped relationship. All three dimensions of ESG—environmental performance, social responsibility and governance—positively affect capacity utilisation, addressing gaps in enhancing firms' capacity utilisation through ESG practices. We identify an indirect transmission channel through which firms' ESG practices influence capacity utilisation, marking a pioneering discovery in our study. Using structural equation modelling (SEM), we confirm that firms' ESG practices enhance capacity utilisation by improving competitiveness and customer stickiness. Additionally, we discuss potential heterogeneity in the impact of ESG performance on capacity utilisation, considering factors such as ownership structure, industry, financial constraints and equity arrangements. Our findings provide insights for governments and companies aiming to incorporate ESG principles into their decision‐making processes to enhance capacity utilisation.
Benzimidazole–Oxadiazole Hybrids—Development in Medicinal Chemistry: An Overview
Authors: Bhat Raveendra Madhukar , Hegde Venkatraman , Budagumpi Srinivasa , Adimule Vinayak , Keri Rangappa S. 
Published: August 2024

ABSTRACTTo increase the success rate of drug discovery, one practical strategy is to begin molecular hybridisation. The presence of two or more pharmacophores in a single unit leads to a pharmacological potency greater than the sum of each individual moiety's potency. Heterocyclic compounds are very widely distributed in nature and are essential for life activities. Benzimidazole and oxadiazole are privileged structures in medicinal chemistry and are widely used in drug discovery and development due to their vast biological properties. The drug‐like properties (like pharmacokinetics and pharmacodynamics) of the individual scaffolds can be improved by benzimidazole–oxadiazole chimeric molecules via a molecular hybridisation approach. Benzimidazole and oxadiazole cores can either be fused or incorporated using either functional groups/bonds. Over the last few decades, drug discovery scientists have predicted that these moieties could be interconnected to yield a novel or modified hybrid compound. Benzimidazole and oxadiazole hybrids were identified as the most potent anticancer, antimicrobial, anti‐inflammatory, antioxidant, anticonvulsant, antidepressant, antihypertensive and antitubercular agents. In this context, the present review describes the biological properties of benzimidazole–oxadiazole (1,3,4 and 1,2,4) hybrids, their possible structure–activity relationship and the mechanism of action studies presented. This review article is intended to stimulate fresh ideas in the search for rational designs of more active and less toxic benzimidazole–oxadiazole hybrid prospective therapeutic candidates, as well as more effective diagnostic agents and pathologic probes.
Remoteness‐attributable financial inequality in dental service utilization in Australian older adults: A Blinder‐Oaxaca decomposition
Authors: Ghanbarzadegan Arash , Ju Xiangqun , Sohn Woosung , Jamieson Lisa 
Published: August 2024

AbstractObjectiveOral health is often overlooked in ageing health issues, despite its impact on overall health and quality of life. Older Australians, especially those in rural and remote areas, face difficulties accessing oral health services. The aim of the study was to investigate the factors that contribute to financial barriers to accessing dental services among the ageing population in Australia in relation to their residential location.MethodThe study included a weighted sample of Australian adults aged 65 years and over from a population‐based survey called the National Study of Adult Oral Health (NSAOH) conducted in 2017–18. Descriptive analysis was conducted and generated cross‐tabulation tables to investigate the distributions of the outcome, exposure and covariates, including Sex, Education level (the highest level of education), Equivalised household income, Dental insurance, Concession card ownership, Difficulty paying a dental bill and last dental visit. Blinder‐Oaxaca decomposition counterfactual analysis was used to explore the potential impact of a person's residence on their financial difficulty accessing dental services.ResultsThe findings showed that 26.2% (95% CI: 24.3–29.3) of major city residents and 30.1% (95% CI: 26.9–33.3) of rural residents avoided or delayed dental visits due to cost. The decomposition analysis indicated that 53.8% of the disparities in the prevalence of avoided or delayed dental visits due to cost were explained by the selected variables, while 46.2% remained unexplained. The explanatory variable with the largest contribution was difficulty paying a $200 dental bill, accounting for 62.4% of the differences, followed by dental insurance, last dental visit and equivalised household income, which explained 42.1%, 20.8% and 14.9% of the differences, respectively.ConclusionRegional/remote populations experience more financial barriers to accessing dental care than major city populations and the identified factors explain a significant proportion of these disparities. Based on the study findings, recommendations include expanding public dental service coverage, evaluating concession card mechanisms and advocating for regular dental visits to mitigate disparities in dental care access.
Comparative analysis of dental implant placement accuracy: Semi‐active robotic versus free‐hand techniques: A randomized controlled clinical trial
Authors: Yang Fan , Chen Jianping , Cao Ruijue , Tang Qingwei , Liu Haiyan , Zheng Yuchen , Liu BeiLei , Huang Min , Wang Zhenshi , Ding Yude , Wang Linhong 
Published: August 2024

AbstractBackgroundRobot‐assisted implant surgery has emerged as a novel digital technology, and the accuracy need further assessment.PurposeThis study aimed to compare the accuracy of single dental implant placement between a novel semi‐active robot‐assisted implant surgery (RAIS) method and the conventional free‐hand implant surgery (FHIS) method through a multicenter, randomized controlled clinical trial.Materials and MethodsPatients requiring single dental implant placement were recruited and randomized into RAIS and FHIS group. Deviations at the platform, apex, and angle between the planned and final implant positions were assessed in both groups. Additionally, the evaluation of instrument and surgical complications was examined.ResultsA total of 140 patients (median age: 35.35 ± 12.55 years; 43 males, 97 females) with 140 implants from four different research centers were included, with 70 patients (70 implants) in the RAIS group and 70 patients (70 implants) in the FHIS group. In the RAIS and FHIS groups, the median platform deviations were 0.76 ± 0.36 mm and 1.48 ± 0.93 mm, respectively (p < 0.001); median apex deviations were 0.85 ± 0.48 mm and 2.14 ± 1.25 mm, respectively (p < 0.001); and median angular deviations were 2.05 ± 1.33° and 7.36 ± 4.67°, respectively (p < 0.001). Similar significant difference also presented between RAIS and FHIS group in platform vertical/horizontal deviation, apex vertical/horizontal deviation. Additionally, implants with self‐tapping characteristics exhibited significantly larger deviations compared with those without self‐tapping characteristics in the RAIS group. Both RAIS and FHIS methods demonstrated comparable morbidity and safety pre‐ and post‐operation.ConclusionsThe results indicated that the RAIS method demonstrated superior accuracy in single dental implant placement compared with the FHIS method. Specifically, RAIS exhibited significantly smaller deviations in platform, apex, and angular positions, as well as platform and apex vertical/horizontal deviations.This clinical trial was not registered prior to participant recruitment and randomization. https://www.chictr.org.cn/showproj.html?proj=195045.
Measuring the performance of Antarctic Treaty decision‐making
Authors: Gardiner Natasha Blaize , Gilbert Neil , Liggett Daniela , Bode Michael 
Published: August 2024

AbstractAgreements reached at the Antarctic Treaty Consultative Meetings (ATCMs) are among the primary means for addressing Antarctic conservation and environmental protection issues. However, according to contemporary scholars, Antarctic Treaty decision‐making is becoming increasingly unresponsive to the rising environmental challenges in the region. We assessed the performance of Antarctic Treaty decision‐making by measuring the rate and diversity of decision‐making over the last 6 decades. To measure the rate, we counted the number of inputs and outputs of ATCMs and calculated the time taken for legally binding outputs to enter into force. To measure diversity, we calculated the range of topics addressed by the inputs and outputs of ATCMs. The average number of agreements reached per ATCM increased from 1961 to 2022. Although the diversity of Antarctic topics discussed at ATCMs remained consistently high, the diversity of topics on which legally binding agreements were adopted declined significantly. Antarctic issues—including those of highest priority—are now almost entirely dealt with through nonbinding, soft‐law agreements. It is plausible that this move away from binding decisions reflects a dynamic governance institution evolving to respond to new pressures. However, we suggest that the change reveals a concerning shift in decision‐making behavior and performance, unique to the treaty's history. Soft law is beneficial in some cases, but its overuse diminishes accountability and transparency, significantly reducing the parties’ abilities to understand and measure their performance, including the outcomes and impacts of decisions. Although the rate and diversity of ATCM inputs and outputs provide only a partial view of decision‐making performance, the exploration of these metrics provides a foundation for asking essential questions about the impacts of Antarctic Treaty governance on the region's environmental protection and conservation.
Partner‐Specific Adaptation in Disfluency Processing
Authors: Yoon Si On , Brown‐Schmidt Sarah 
Published: August 2024

AbstractSpeakers tend to produce disfluencies when naming unexpected or complex items; in turn, when perceiving disfluency, listeners tend to expect upcoming reference to items that are unexpected or complex to name. In two experiments, we examined if these disfluency‐based expectations are routine, or instead, if they adapt to the way the speaker uses disfluency in the current context in a talker‐specific manner. Participants listened to instructions to look at objects in contexts with several images, some of which lacked conventional names. We manipulated the co‐occurrence of disfluency and reference to novel versus familiar objects in a single talker situation (Experiment 1) and in a multi‐talker situation (Experiment 2). In the predictive condition, disfluent expressions referred to novel objects, and fluent expressions referred to familiar objects. In the nonpredictive condition, fluent and disfluent trials referred to either familiar or novel objects. Participants’ gaze revealed that listeners more readily predicted familiar images for fluent trials and novel images for disfluent trials in the predictive condition than in the nonpredictive condition. In sum, listeners adapted their expectations about upcoming words based on recent experience with disfluency. Disfluency is not invariably processed, but instead a cue that is flexibly interpreted depending on the local context even in a multi‐talker setting.
The impact of dynamic caudal type homeobox 2 expression on the differentiation of human trophoblast lineage during implantation
Authors: Rong Lujuan , Xiang Lifeng , Ai Zongyong , Niu Baohua , Wang Yaqing , Yin Yu , Feng Chun , Shi Gaohui , Chen Tingwei , Yang Jie , Luo Xi , Bai Yun , Zhou Xiaoting , Liu Xiaoping , Zheng Haishan , Ke Yang , Li Tianqing , Wu Ze 
Published: August 2024

AbstractThe trophoblast lineage differentiation represents a rate‐limiting step in successful embryo implantation. Adhesion, invasion and migration processes within the trophoblast are governed by several transcription factors. Among them, CDX2 is a critical regulator shaping the destiny of the trophoblast. While its altered expression is a linchpin initiating embryo implantation in mice, the precise influence of CDX2 on the functionality and lineage differentiation of early human trophoblast remains unclear. In this study, we employed well‐established human trophoblast stem cell (hTSC) lines with CDX2 overexpression coupled with a 3D in vitro culture system for early human embryos. We revealed that the downregulation of CDX2 is a prerequisite for syncytialization during human embryo implantation based on immunofluorescence, transcriptome analysis, CUT‐tag sequencing and the construction of 3D human trophoblast organoids. While CDX2 overexpression inhibited syncytialization, it propelled hTSC proliferation and invasive migration. CDX2 exerted its influence by interacting with CGA, PTGS2, GCM1, LEF1 and CDH2, thereby hindering premature differentiation of the syncytiotrophoblast. CDX2 overexpression enhanced the epithelial–mesenchymal transition of human trophoblast organoids. In summary, our study provides insights into the molecular characteristics of trophoblast differentiation and development in humans, laying a theoretical foundation for advancing research in embryo implantation.