bluuebunny/crossref_metadata_2025_split huggingface dataset:
L'évènement culturel en régie directe, un levier pour l'attractivité durable du territoire ? Analyse des conditions managériales de succès
Authors: Soldo Edina , Arnaud Charlène , Keramidas Olivier 
Published: January 2014

L’un des problèmes inhérents à la gestion des administrations contemporaines décentralisées relève d’une modification profonde de leurs modes d’action (Divay et Mazouz, 2008). On constate notamment une intégration croissante des politiques et actions culturelles dans les stratégies territoriales et ce, afin de répondre à la volonté des territoires de s’inscrire dans un processus d’attractivité durable. Afin d’atteindre cette finalité stratégique, de plus en plus de territoires optent pour la mise en œuvre d’évènements, notamment culturels, considérés comme des objectifs intermédiaires. Cette ruée vers la ville festive et évènementielle marque un changement dans le management territorial qui s’oriente de plus en plus vers un management de projet et questionne tout à la fois la conception de la stratégie autour de l’évènement ainsi que sa mise en œuvre au sein de l’organisation et sur le territoire. Ainsi le cas de la saison « Picasso-Aix 2009 » permet ici, à travers une étude de cas unique et exemplaire, de s’interroger sur les conditions managériales qui permettent de maximiser les potentialités de l’évènement culturel en tant que levier d’attractivité territoriale durable. Résumé pour les praticiens Cette recherche met en exergue les risques d’une « événementialisation » de la culture et des territoires et questionne les modalités de management d’un évènement culturel à l’échelon intercommunal (éléments relatifs à la stratégie territoriale) et produit en régie directe par les services d’une intercommunalité (éléments relatifs aux modalités de gestion interne). Au-delà d’une monographie éclairante, cet article propose une boîte à outil de facteurs clés de succès génériques dans laquelle les praticiens peuvent piocher afin de construire leur portefeuille d’évènements culturels à l’échelle territoriale, en termes d’élaboration stratégique ainsi que de gestion de projet et de parties prenantes.
A retrospective study of central venous catheters GCRI experience
Authors: Jain Sachin A. , Shukla Shilin N. , Talati Shailesh S. , Parikh Sonia K. , Bhatt Shivani J. , Maka Vinayak 
Published: January 2014

Abstract
Background: The use of central venous catheters (CVCs) has greatly improved the quality-of-care in cancer patients, yet these catheters may cause serious infectious and thrombotic complications. The aim of this retrospective study was to study the various types of CVCs and their complications. Materials and Methods: We studied retrospectively 213 cases of CVCs in our institute with their indications, type and complications from August 2010 to July 2011. Results: A total of 213 CVCs were inserted in patients with hematological (62%) and solid organ malignancies (38%). Ninety-eight patients (46%) had peripheral inserted central catheter (PICC), 90 (42%) patients had Hickman catheters and 25 (12%) had a port. The median duration of retention of Hickman catheters was 104 days (3-365 days), for the peripherally inserted central catheters was 59 days (3-100 days) and for the port it was 280 days (45-365 days). Non-infective complications were more than infective (12% vs. 7%). The most common complication was non-infective occlusion and thrombophlebitis. In one patient with PICC thrombosis occurred in the cephalic, radial and ulnar vein and in one patient with port thrombosis occurred in the superior vena cava. Organisms were isolated in 60% (12 out of 20) of cultures. Common organisms isolated were Pseudomonas aeruginosa in 5 (42%), Staphylococcus aureus in 2 (16%), Escherichia coli in 2 (16%) and Aspergillus in 3 (25%) patients. 7 out of 12 infected patients had negative blood cultures within 7 days of antibiotic treatment, 5 patients remained positive for more than 7 days with antibiotics. In 155 patients (73%), the desired treatment protocol was completed and at present there are still 28 patients (13%) with catheters. 5 patients (2.3%) died of febrile neutropenia and septicemia with multi-organ failure. In 5 patients (2.3%), the catheters (1 Port, 1 Hickman and 3 PICC) were prematurely removed because of thrombosis. Conclusion: CVCs are better options to facilitate the long-term vascular access provided infection is prevented with meticulous care and treated promptly with proper antibiotics. Most CVCs is acceptable to patients.
Malignant lymphoma in Eastern India: A retrospective analysis of 455 cases according to World Health Organization classification
Authors: Mondal Santosh Kumar , Mandal Palash Kumar , Samanta Tarun Kumar , Chakaborty Subrata , Roy Saptarshi Dutta , Roy Shravasti 
Published: January 2014

Abstract
Background: Malignant lymphoma (ML) is one of the most common cancers and is most prevalent in developed countries. The distribution of different subtypes of ML varies in the different geographical locations according to World Health Organization (WHO) Classification. Aims and Objectives : The study was aimed to analyze the different patterns of ML in Eastern India and to compare it with other geographical locations. Materials and Methods: Four hundred and fifty five patients of two large hospitals in Eastern India were included over a period of four years and were categorized according to WHO classification, using the morphology and immunohistochemistry. Results: There were 347 (76.3%) non Hodgkin lymphomas (NHL), and 108 (23.7%) Hodgkin lymphomas (HL). Diffuse large B-cell lymphoma was the most common of the NHL type (35.2%) followed by the follicular lymphoma (19.3%). B-cell lymphoblastic lymphoma was the least common type of NHL (1.4%). Mixed cellularity (33.3%) and nodular sclerosis (26.9%) were the two most common type of HL. Childhood lymphoma comprised of 12.5%of all ML. T-cell NHL and HL were the common lymphomas in this age group. Conclusion: Incidence of follicular lymphoma is lower compared to western studies and mixed cellularity is the most common subtype of HL unlike nodular sclerosis subtype in Western world. Burkitt′s type NHL though is the most common subtype of childhood ML in many studies. However, in our study, T-cell NHL is the most common type of childhood ML.
Needle core biopsy for breast lesions: An audit of 467 needle core biopsies
Authors: Radhakrishna Selvi , Gayathri Anu , Chegu Deepa 
Published: January 2014

Abstract
Background: Breast cancer is the commonest cancer among women in urban India. Triple assessment includes clinical, radiological and cytological assessment of breast lesions. Guided core needle biopsy has replaced fine needle aspiration cytology in most of the western countries. In resource poor countries FNAC is still a very valuable and cost effective method to diagnose breast lesions. Pitfalls include increased rates of non diagnostic smears, and inadequate smears. Further procedures may be required and this increases the cost, anxiety and delay in diagnosis. Aims: The aim of this study is to analyze the concordance of radiological and histopathology findings in BI-RADS category 3,4,5 lesions following a core biopsy. Materials and Methods: Data was retrospectively collected from consecutive symptomatic and opportunistic screen detected patients with abnormalities who underwent ultrasound guided interventional procedures from Jan 2010 to Aug 2011. Symptomatic patients underwent clinical examination, mammogram and breast ultrasound. Women under 35 years of age had only breast ultrasound. Core biopsy was performed under ultrasound guidance or clinically by a breast surgeon/ radiologist for BI-RADS category 3,4,5 lesions. Statistical Methods: Chi square test was done to show the strength of association of imaging findings and histopathology results of core biopsy. Results: 437 patients were symptomatic and 30 patients had screen detected abnormalities. The positive predictive value for BI-RADS 5 lesions for malignancy is 93.25% and the negative predictive value of BI-RADS category 3 lesions for cancer is 98.4%. False negative diagnosis on core biopsy was 0.85%. We were able to defer surgery in 60% of the patients with a clear radiological and pathological benign diagnosis. Conclusion: The PPV and NPV for cancer is high with needle core biopsy in BI-RADS 3,4,5 lesions. Where there is no discordance between clinical, radiology and pathology findings, surgery can be avoided in benign lesions. While in resource poor countries FNAC continues to be a valuable method in the diagnosis of palpable and non palpable breast lesions, the practice of needle core biopsy provides the most accurate and optimal diagnostic information.
Rare childhood tumors in a Turkish pediatric oncology center
Authors: Tacyildiz Nurdan , Özyörük Derya , Yavuz Gülsan , Ünal Emel Cabı , Dinçaslan Handan , Tanyıldız Gülşah Oktay , Gördü Zülfikar , Şıklar Zeynep , Berberoğlu Merih , Öcal Gönül 
Published: January 2014

Abstract
Background: It has been estimated that rare tumor rate is about 15% of all childhood cancer in United States. According to Turkish Pediatric Oncology Group (TPOG) datas, 8889 children were diagnosed between 2002 and 2008 in our country and 3.7% of them were diagnosed as rare tumors. Aim: To investigate the frequency and clinical features of rare tumors in our pediatric oncology center. Materials and Methods: A total of 43 cases that have diagnosed as rare tumor in 574 cancer patients between the yaer 2002 and 2012 were reviewed retrospectively. All cases definitive diagnosis were established by histopathological and immunohistochemical studies. Results: Frequency of rare tumors was 7.4% in our center. Benign and border line rare tumors were 27 (62.7%) cases, malignant rare tumor were 16 (37.2%) cases. Median follow-up period was 48 months (between 1 and 110 months). Six of the malignant rare tumors were died with progressive disease (synovial sarcoma, mixed malignant mesenchymal tumor, undifferentiated sarcoma, plexus choroideus carcinoma, renal peripheral primitive neuroectodermal tumor, adrenocortical carcinoma). Malignant rare tumor mortality rate was found 37.5% in our clinic. Conclusion: We have found that our rare tumor rate (7.4%) was higher than Turkish rare tumor rate (3.7%) according to TPOG′s datas. However, it was still lower than rare tumor rates of western countries (15%), probably due to difficulties of diagnosis and referral problems.
Retrospective analysis of the clinical and demographic variables on the outcomes after second-line treatment in advanced non-small cell lung cancer
Authors: Sau Sourav , Biswas Anirban , Roy Amitava , Sau Saikat , Ganguly Subir 
Published: January 2014

Abstract
Background: Platinum based doublets chemotherapy are the standard of care for metastatic or advanced non-small cell lung carcinoma. This leads to modest survival advantage and improve quality-of-life. However, patients with advanced or metastatic disease eventually present disease progression and needs second-line systemic therapy in a selected group of patients or other supportive measures. There is very little knowledge available from the literature about the prognostic variables in patients, who receive second-line therapy. Materials and Methods: We retrospectively reviewed 329 patients received second-line treatment from July 2007 to September 2011 in the Department of Radiation Oncology, Burdwan Medical College and Hospital. For statistical analysis, 12 potential prognostic variables included. Univariate and multivariate regression analysis carried out to identify the prognostic variables associated with survival. Results: The results of univariate analysis for overall survival (OS) and survival after second-line therapy identified to have prognostic significance: Age, sex, performance status, smoking history, serum lactate dehydrogenase, histopathology, first-line chemotherapy and its response and second-line therapy except the stage at diagnosis and site of failure after first-line therapy. The multivariate Cox regression analysis has shown that only performance and second-line therapy were independent prognostic variables for survival after second-line treatment and above these prognostic factors; age, smoking status and progression free survival also for OS. Conclusion: The performance status has shown consistent result as a prognostic factor in univariate and multivariate analysis for OS and survival after second-line therapy. These findings may also facilitate pretreatment prediction of survival and be used for selecting patients for the correct choice of cytotoxic therapy.
Inflammatory myofibroblastic tumor of kidney with heterotopic bone formation: An unusual case mimicking a renal malignancy
Authors: Navale Pooja , Menon Santosh , Bakshi Ganesh , Pruthy Ritesh , Desai Sangeeta 
Published: January 2014

AbstractInflammatory myofibroblastic tumor (IMFT) or pseudotumor is a rare tumor that can be seen in various organs. It is an enigmatic tumor of unknown etiology and difficult to differentiate from malignancy, clinically as well as radiologically. Histologically, it is composed of variable proportions of proliferating spindle myofibroblasts, fibroblasts, extracellular collagen, lymphocytes and plasma cells. This mainly affects the urinary bladder or prostate. Renal involvement is extremely rare and may pose diagnostic difficulty to the clinician. We describe a renal IMFT, mimicking renal malignancy, having unusual histological features.
Hand foot syndrome associated with standard dose cytarabine
Authors: Sharma Atul , Baghmar Saphalta 
Published: January 2014

AbstractHand-foot syndrome, is a side effect of cytotoxic chemotherapy, causes erythema, dysthesias, swelling of palms and soles and sometimes blisters. Rarely, it may ulcerate. The most commonly used drug that frequently causes this reaction is 5-fluorouracil or its prodrug oral capecitabine. High dose cytarabine is known to cause HFS. Here we report a case of HFS caused by standard dose cytarabine.
Potential Application of Temozolomide in Mesenchymal Stem Cell-Based TRAIL Gene Therapy Against Malignant Glioma
Authors: Kim Seong Muk , Woo Ji Sun , Jeong Chang Hyun , Ryu Chung Heon , Jang Jae-Deog , Jeun Sin-Soo 
Published: January 2014

Abstract
Because the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills tumor cells, it is one of the most promising candidates for cancer treatment. TRAIL-secreting human mesenchymal stem cells (MSC-TRAIL) provide targeted and prolonged delivery of TRAIL in glioma therapy. However, acquired resistance to TRAIL of glioma cells is a major problem to be overcome. We showed a potential therapy that used MSC-TRAIL combined with the chemotherapeutic agent temozolomide (TMZ). The antitumor effects of the combination with MSC-TRAIL and TMZ on human glioma cells were determined by using an in vitro coculture system and an in vivo experimental xenografted mouse model. Intracellular signaling events that are responsible for the TMZ-mediated sensitization to TRAIL-induced apoptosis were also evaluated. Treatment of either TRAIL-sensitive or -resistant human glioma cells with TMZ and MSC-TRAIL resulted in a significant enhancement of apoptosis compared with the administration of each agent alone. We demonstrated that TMZ effectively increased the sensitivity to TRAIL-induced apoptosis via extracellular signal-regulated kinase-mediated upregulation of the death receptor 5 and downregulation of antiapoptotic proteins, such as X-linked inhibitor of apoptosis protein and cellular FLICE-inhibitory protein. Subsequently, this combined treatment resulted in a substantial increase in caspase activation. Furthermore, in vivo survival experiments and bioluminescence imaging analyses showed that treatment using MSC-TRAIL combined with TMZ had greater therapeutic efficacy than did single-agent treatments. These results suggest that the combination of clinically relevant TMZ and MSC-TRAIL is a potential therapeutic strategy for improving the treatment of malignant gliomas.
Dynamics of sea level rise and coastal flooding on a changing landscape
Authors: Bilskie M. V. , Hagen S. C. , Medeiros S. C. , Passeri D. L. 
Published: January 2014

AbstractStandard approaches to determining the impacts of sea level rise (SLR) on storm surge flooding employ numerical models reflecting present conditions with modified sea states for a given SLR scenario. In this study, we advance this paradigm by adjusting the model framework so that it reflects not only a change in sea state but also variations to the landscape (morphologic changes and urbanization of coastal cities). We utilize a numerical model of the Mississippi and Alabama coast to simulate the response of hurricane storm surge to changes in sea level, land use/land cover, and land surface elevation for past (1960), present (2005), and future (2050) conditions. The results show that the storm surge response to SLR is dynamic and sensitive to changes in the landscape. We introduce a new modeling framework that includes modification of the landscape when producing storm surge models for future conditions.
The Pacific quasi‐decadal oscillation (QDO): An important precursor toward anticipating major flood events in the Missouri River Basin?
Authors: Wang Shih‐Yu , Hakala Kirsti , Gillies Robert R. , Capehart William J. 
Published: January 2014

AbstractMeasurements taken by the Gravity Recovery and Climate Experiment satellites indicated a continued water storage increase over the Missouri River Basin (MRB) prior to the 2011 flood event. An analysis of the major hydrologic variables in the MRB, i.e., those of soil moisture, streamflow, groundwater storage, and precipitation, show a marked variability at the 10–15 year time scale coincident with the water storage increase. A climate diagnostic analysis was conducted to determine what climate forcing conditions preceded the long‐term changes in these variables. It was found that precipitation over the MRB undergoes a profound modulation during the transition points of the Pacific quasi‐decadal oscillation and associated teleconnections. The results infer a prominent teleconnection forcing in driving the wet/dry spells in the MRB, and this connection implies persistence of dry conditions for the next 2 to 3 years.
Driven around the bend: Spatial evolution and controls on the orientation of helical bend flow in a natural submarine gravity current
Authors: Sumner E. J. , Peakall J. , Dorrell R. M. , Parsons D. R. , Darby S. E. , Wynn R. B. , McPhail S. D. , Perrett J. , Webb A. , White D. 
Published: January 2014

AbstractSubmarine channel systems transport vast amounts of terrestrial sediment into the deep sea. Understanding the dynamics of the gravity currents that create these systems, and in particular, how these flows interact with and form bends, is fundamental to predicting system architecture and evolution. Bend flow is characterized by a helical structure and in rivers typically comprises inwardly directed near‐bed flow and outwardly directed near‐surface flow. Following a decade of debate, it is now accepted that helical flow in submarine channel bends can exhibit a variety of structures including being opposed to that observed in rivers. The new challenge is to understand what controls the orientation of helical flow cells within submarine flows and determines the conditions for reversal. We present data from the Black Sea showing, for the first time, the three‐dimensional velocity and density structure of an active submarine gravity current. By calculating the forces acting on the flow, we evaluate what controls the orientation of helical flow cells. We demonstrate that radial pressure gradients caused by across‐channel stratification of the flow are more important than centrifugal acceleration in controlling the orientation of helical flow. We also demonstrate that nonlocal acceleration of the flow due to topographic forcing and downstream advection of the cross‐stream flow are significant terms in the momentum balance. These findings have major implications for conceptual and numerical models of submarine channel dynamics, because they show that three‐dimensional models that incorporate across‐channel flow stratification are required to accurately represent curvature‐induced helical flow in such systems.
Normalized particle size distribution for remote sensing application
Authors: Delanoë J. M. E. , Heymsfield A. J. , Protat A. , Bansemer A. , Hogan R. J. 
Published: January 2014

AbstractThe ice particle size distribution (PSD) is fundamental to the quantitative description of a cloud. It is also crucial in the development of remote sensing retrieval techniques using radar and/or lidar measurements. The PSD allows one to link characteristics of individual particles (area, mass, and scattering properties) to characteristics of an ensemble of particles in a sampling volume (e.g., visible extinction (σ), ice water content (IWC), and radar reflectivity (Z)). The aim of this study is to describe a normalization technique to represent the PSD. We update an earlier study by including recent in situ measurements covering a large variety of ice clouds spanning temperatures ranging between −80°C and 0°C. This new data set also includes direct measurements of IWC. We demonstrate that it is possible to scale the PSD in size space by the volume‐weighted diameter Dm and in the concentration space by the intercept parameter and obtain the intrinsic shape of the PSD. Therefore, by combining , Dm, and a modified gamma function representing the normalized PSD shape, we are able to approximate key cloud variables (such as IWC) as well as cloud properties which can be remotely observed (such as Z) with an absolute mean relative error smaller than 20%. The underlying idea is to be able to retrieve the PSD using two independent measurements. We also propose parameterizations for ice cloud key parameters derived from the normalized PSD. We also investigate the effects of uncertainty present in the ice crystal mass‐size relationships on the parameterizations and the normalized PSD approach.
Robust Ordinal Regression
Authors: Corrente Salvatore , Greco Salvatore , Kadziński Miłosz , Słowiński Roman 
Published: January 2014

AbstractAny multiple Criteria Decision Aiding (MCDA) method needs some preference parameters. The Decision Maker (DM) could be asked to provide directly all these parameters; however, because it needs a great cognitive effort, the indirect preference information is more used in practice. Starting from the indirect preference information, usually there could be more than one set of preference parameters compatible with the information provided by the DM and the choice of only one of them could be considered arbitrary and meaningless. Robust Ordinal Regression (ROR) considers all the sets of compatible preference parameters using the possible and necessary preference relations. The necessary preference relation holds between two alternativesaandbifais at least as good asbfor all sets of compatible preference parameters, whereas the possible preference relations holds betweenaandbifais at least as good asbfor at least one set of compatible preference parameters. In this article, we introduce the basic concepts and the main developments of ROR.