bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐dose pegylated recombinant human granulocyte‐colony stimulating factor as hematopoietic support for adjuvant chemotherapy in Chinese patients with breast cancer: An open‐label, randomized, non‐inferiority trial
Authors: Yang Sheng , Chen Shan‐shan , Zhang Chang‐gong , Zhou Ying‐lei , Xiu Meng , Zhang Pin 
Published: June 2024

AbstractAimsThe recommended dosage of pegylated recombinant human granulocyte‐colony stimulating factor (PEG‐rhG‐CSF) for Western chemotherapy patients is 6 mg per cycle. However, for Eastern Asians, the optimal dose remains unknown.MethodsThis open‐label, randomized, non‐inferiority trial (NCT05283616) enrolled Chinese female breast cancer patients receiving adjuvant chemotherapy. Participants were randomized to receive either 3 or 6 mg of PEG‐rhG‐CSF per cycle, stratified by body weight (BW; ≤60 kg vs. >60 kg). The primary endpoint was timely absolute neutrophil count (ANC) recovery before the second cycle of chemotherapy.ResultsA total of 122 patients were randomized and 116 were included for efficacy analyses. The timely ANC recovery rate in the 3 mg arm was 89.8%, compared to 93.0% in the 6 mg arm (one‐sided 95% confidence interval [CI] lower limit for difference: −11.7%), meeting the prespecified non‐inferiority margin of 15%. The rate was 93.3% with PEG‐rhG‐CSF 3 mg and 96.6% with 6 mg in patients with BW ≤ 60 kg, and 86.2% and 89.3%, respectively, in those with BW > 60 kg. Although the incidence of severe neutropenia was similar across arms, the occurrence of excessively high ANC and white blood cell counts was higher in the 6 mg arm. No grade ≥3 adverse events related to PEG‐rhG‐CSF occurred.ConclusionThree milligrams of PEG‐rhG‐CSF per cycle provided non‐inferior neutrophil protection and attenuated neutrophil overshoot compared to 6 mg doses. This low‐dose regimen could be a new supportive care option for Chinese breast cancer patients receiving anthracycline‐based adjuvant chemotherapy.
Investigating teacher orchestration load in scripted CSCL: A multimodal data analysis perspective
Authors: Hakami Lubna , Hernández‐Leo Davinia , Amarasinghe Ishari , Sayis Batuhan 
Published: June 2024

AbstractDespite the growing interest in using multimodal data to analyse students' actions in Computers‐Supported Collaborative Learning (CSCL) settings, studying teacher's orchestration load in such settings remains overlooked. The notion of classroom orchestration, and orchestration load, offer a lens to study the implications of increasingly complex technology‐supported learning environments on teacher performance. A combination of multimodal data may aid in understanding teachers' orchestration actions and, as a result, gain insights regarding the orchestration load teachers perceive in scripted CSCL situations. Studying teacher orchestration load in CSCL helps understand the workload teachers experience while facilitating student collaboration and assists in informing design decisions for teacher supporting tools. In this paper, we collect and analyse data from different modalities (i.e. electrodermal activity, observation notes, log data, dashboard screen recordings and responses to self‐reported questionnaires) to study teachers' orchestration load in scripted CSCL. A tool called PyramidApp was used to deploy CSCL activities and a teacher‐facing dashboard was used to facilitate teachers in managing collaboration in real time. The findings of the study show the potential of multimodal data analysis in investigating and estimating the orchestration load experienced by teachers in scripted CSCL activities. Study findings further demonstrate factors emerging from multimodal data such as task type, activity duration, and number of students influenced teachers' orchestration load.
Pharmacogenomic studies of fertility outcomes in pediatric cancer survivors – A systematic review
Authors: Stenta Tayla , Assis Michael , Ayers Katie , Tucker Elena J. , Halman Andreas , Gook Debra , Sinclair Andrew H. , Elliott David A. , Jayasinghe Yasmin , Conyers Rachel 
Published: June 2024

AbstractFor the same age, sex, and dosage, there can be significant variation in fertility outcomes in childhood cancer survivors. Genetics may explain this variation. This study aims to: (i) review the genetic contributions to infertility, (ii) search for pharmacogenomic studies looking at interactions of cancer treatment, genetic predisposition and fertility‐related outcomes. Systematic searches in MEDLINE Ovid, Embase Classic+Embase, and PubMed were conducted using the following selection criteria: (i) pediatric, adolescent, and young adult cancer survivors, below 25 years old at the time of diagnosis, (ii) fertility outcome measures after cancer therapy, (iii) genetic considerations. Studies were excluded if they were (i) conducted in animal models, (ii) were not published in English, (iii) editorial letters, (iv) theses. Articles were screened in Covidence by at least two independent reviewers, followed by data extraction and a risk of bias assessment using the Quality in Prognostic Studies tool. Eight articles were reviewed with a total of 29 genes. Outcome measures included sperm concentration, azoospermia, AMH levels, assessment of premature menopause, ever being pregnant or siring a pregnancy. Three studies included replication cohorts, which attempted replication of SNP findings for NPY2R, BRSK1, FANCI, CYP2C19, CYP3A4, and CYP2B6. Six studies were rated with a high risk of bias. Differing methods may explain a lack of replication, and small cohorts may have contributed to few significant findings. Larger, prospective longitudinal studies with an unbiased genome‐wide focus will be important to replicate significant results, which can be applied clinically.
Emerging clinical role of proprotein convertase subtilisin/kexin type 9 inhibition—Part one: Pleiotropic pro‐atherosclerotic effects of PCSK9
Authors: Cao Zhang Alexander M. , Ziogos Efthymios , Harb Tarek , Gerstenblith Gary , Leucker Thorsten M. 
Published: June 2024

AbstractBackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily recognized for its role in lipid metabolism, but recent evidence suggests that it may have broader implications due to its diverse tissue expression.ObjectiveThis review aims to explore the multifaceted functions of PCSK9, highlighting its pro‐atherosclerotic effects, including its impact on circulating lipoprotein variables, non‐low‐density lipoprotein receptors, and various cell types involved in atherosclerotic plaque development.ConclusionsPCSK9 exhibits diverse roles beyond lipid metabolism, potentially contributing to atherosclerosis through multiple pathways. Understanding these mechanisms could offer new insights into therapeutic strategies targeting PCSK9 for cardiovascular disease management.
Prophylaxis with recombinant factor IX Fc fusion protein reduces the risk of bleeding and delays time to first spontaneous bleed event in previously untreated patients with haemophilia B: A post hoc analysis of the PUPs B‐LONG study
Authors: Nolan Beatrice , Recht Michael , Rendo Pablo , Falk Aletta , Foster Meredith , Casiano Sandra , Rauch Antoine , Shapiro Amy 
Published: June 2024

AbstractObjectivesHaemophilia B (HB), characterised by deficient factor IX (FIX), leads to spontaneous bleeds. Severe cases require prophylactic FIX replacement. This post hoc analysis assessed the first spontaneous bleeds among previously untreated patients (PUPs) with HB treated with recombinant FIX Fc fusion protein (rFIXFc) (NCT02234310) to identify factors influencing bleeds.MethodsSubjects included paediatric PUPs with HB (≤2 IU/dL endogenous FIX). Analyses described treatment patterns (on demand [OD] vs. prophylaxis) and prophylaxis type (started on vs. switched to prophylaxis). Kaplan–Meier analyses assessed the time to first spontaneous bleed, including median time to event and fitting models with predictors for treatment regimen and/or baseline age.ResultsPUPs B‐LONG enrolled 33 subjects. Baseline age did not influence the time to first spontaneous bleed for any rFIXFc regimen. Those who started on prophylaxis with rFIXFc (n = 11), compared with those treated OD (n = 22), had an extended time to first spontaneous bleed. Starting prophylaxis afforded a 93% reduced risk of first spontaneous bleed versus starting OD (hazard ratio [95% confidence interval]: 0.071 [0.009–0.592]) (p = .015).ConclusionrFIXFc prophylaxis, particularly starting early, reduced the risk of bleeding and delayed time to first spontaneous bleed compared with rFIXFc OD. Hence, initial treatment regimens impact bleed patterns in paediatric PUPs.
Stearic acid enhanced starch nanocrystal integration in cassava starch film
Authors: Nzama Nkosingiphile L. , Dufresne Alain , Amonsou Eric O. 
Published: June 2024

SummaryStarch nanocrystals (SNCs) have emerged as promising biodegradable nanomaterial for the enhancement of biopolymer films' properties. Nevertheless, using SNCs alone is difficult due to restricted capacity for nanocrystal integration within the film's matrix. The objective of this study was to enhance the properties of biopolymer films using waxy corn starch nanocrystals supplemented with stearic acid. Cassava starch films containing varying proportions of SNCs (0–20 wt.% starch) and steric acid (2%) were prepared and characterised. The inclusion of stearic acid substantially improved SNC integration from 5% to 15%, yielding nanocomposite films with better tensile strength, thermal stability and barrier properties than those prepared with native starch or starch‐fatty acid alone. The improvement in film properties was attributed to V‐amylose complexes formation, increased crystallinity and hydrophobicity. Microscopy images revealed homogenous film surfaces, depicting greater nanocrystal dispersibility. The supplementation of lipid additives offers a valuable strategy to improve the integration of SNCs in film matrices.
A detective story of intermittent fasting effect on immunity
Authors: Ma Ru‐xue 
Published: June 2024

AbstractIntermittent fasting (IF) refers to periodic fasting routines, that caloric intake is minimized not by meal portion size reduction but by intermittently eliminating ingestion of one or several consecutive meals. IF can instigate comprehensive and multifaceted alterations in energy metabolism, these metabolic channels may aboundingly function as primordial mechanisms that interface with the immune system, instigating intricate immune transformations. This review delivers a comprehensive understanding of IF, paying particular attention to its influence on the immune system, thus seeking to bridge these two research domains. We explore how IF effects lipid metabolism, hormonal levels, circadian rhythm, autophagy, oxidative stress, gut microbiota, and intestinal barrier integrity, and conjecture about the mechanisms orchestrating the intersect between these factors and the immune system. Moreover, the review includes research findings on the implications of IF on the immune system and patients burdened with autoimmune diseases.
Effect of comprehensive nursing intervention on the formation of pressure sore in patients undergoing orthopaedic surgery in prone position
Authors: Li Li , Li Jun 
Published: June 2024

AbstractPressure ulcers are a common complication of prone orthopaedic surgery, causing pain and inconvenience to patients. This study aimed to evaluate a comprehensive nursing intervention for pressure ulcer formation in these patients. A total of 120 patients undergoing prone orthopaedic surgery were randomly divided into two groups. The study group (60 patients) received a comprehensive nursing intervention, whereas the control group (60 patients) received a routine nursing intervention. After 2 weeks, the comprehensive nursing intervention significantly reduced the incidence and degree of pressure sores and led to a shorter recovery time than the routine nursing intervention (p < 0.05). The incidence of postoperative wound complications was decreased, and patient satisfaction was significantly improved (p < 0.05). The Hamilton Anxiety Scale, Hamilton Depression Scale and visual analogue scale scores of the study group were significantly lower than those of the control group, and the Short Form 36 Health Survey Questionnaire scores were higher than those of the control group (p < 0.05). A comprehensive nursing intervention can significantly reduce the incidence and degree of pressure ulcers, accelerate recovery time, reduce postoperative wound complications and improve the quality of life and satisfaction of patients undergoing prone orthopaedic surgery.
Government awards to CEOs
Authors: Belot François , Waxin Timothée 
Published: June 2024

AbstractThis paper investigates the value and corporate governance consequences of government awards for a sample of French CEOs appointed to the national Order of the Legion of Honor (Légion d'honneur). Short‐term market reactions surrounding award announcements are significantly positive, whereas the valuation of firms with awarded CEOs is greater than that of (matched) firms with nonawarded CEOs. We explore the channels through which government awards create value and find evidence that they provide awarded CEOs and their firms with increased political access. We also observe that government awards are associated with better corporate governance in that awarded CEOs are more likely to be fired for poor performance. The negative effects that have been documented for media awards and are associated with CEOs’ superstar status do not seem to apply to state awards.
Determination of the relationship between depression and suicide in young adolescents
Authors: Tuncay Suat , Sarman Abdullah 
Published: June 2024

AbstractObjectiveThis study was designed to explore the relationships between depression, and the likelihood of suicide among young adolescents by considering various factors.Design and SamplesIt was conducted in a descriptive‐cross‐sectional format, with fieldwork spanning from November 16, 2022, to June 30, 2023. The study assessed the likelihood of depression, and suicide in young adolescents attending a university in Eastern Turkey.MeasurementsSociodemographic features survey form, Beck's Depression Inventory and Suicide Probability Scale were used to collect data.ResultsThe results from this investigation indicated that women, individuals with chronic illnesses, those with a history of psychiatric conditions, those expressing a constant desire to die, those with suicidal thoughts or plans, and those with a family member who had attempted suicide exhibited significantly higher mean scores for depression and suicide. There was a positive correlation between high depression scores and suicidal tendencies. However, no conclusive evidence of a link between depression, and suicide was established.ConclusionsIn this study, certain demographic and psychological factors were identified as correlating with elevated levels of depression and suicidal tendencies among young adolescents. It is imperative that individuals identified as being at risk be promptly referred to appropriate units for comprehensive interventions and support.
Exploring the therapeutic potential of plasma from intermittent fasting and untreated rats on aging‐induced liver damage
Authors: Allahverdi Hüseyin 
Published: June 2024

AbstractThis research aims to investigate the effects of plasma from 12‐month‐old intermittently fasting rats (IFpls) and untreated rats (Npls) on the liver biomolecules and histological changes in 24‐month‐old male Sprague–Dawley rats. Fasting rats underwent an 18‐h daily fasting period and a 6‐h feeding window for 35 days. The plasma was administered bi‐daily, and blood samples were examined for specific liver biomolecules. Fourier transform infrared (FTIR) spectroscopy and linear discriminant analysis (LDA) was used to identify molecular profiles. Liver sections were stained for histopathological evaluation, and the expression levels of Notch signalling pathway components were assessed. Distinct molecular profiles were identified across liver biomolecules, lipids, proteins and nucleic acids with high accuracy. Notably, IFpls was found to protect against hepatic instability, microvesicular steatosis and liver fibrosis by decreasing lymphatic infiltration density and Notch pathway expression levels. Both treatments reduced protein oxidation and carbonylation, with Npls showing a pronounced decrease in protein oxidation. Furthermore, Npls increased protein conformation and glycogen/phosphate content, while IFpls increased glucose/protein content. Both IFpls and Npls induce substantial and unique alterations in liver biomolecules. IFpls offers a protective effect on various liver conditions, while Npls exhibits promising results in reducing protein oxidation and altering biomolecule content. These findings offer valuable insights for future research and potential therapeutic approaches.
Multidisciplinary patient‐centered approach to the management of skin cancer
Authors: Dréno Brigitte , Mohr Peter , Sicard Jérôme , Persson Carina , Barba Ibáñez Enrique , Saint Aroman Markéta , Alivon Maureen 
Published: June 2024

AbstractIn recent years, new approaches for optimal patient management of cancer have focused on patient‐centered care, with integration of tumour‐directed treatment and patient‐directed supportive and palliative care throughout the disease journey from prevention through screening, diagnosis, treatment, and follow‐up. In 2022, at the International Forum of Dermatology (IFD), a scientific session was entirely dedicated to highlight recent developments on patient‐centered approaches in skin cancer. An international panel of different groups of participants involved in a patient's journey on the management of skin cancer presented and discussed challenges and barriers that persist in the field of skin cancer prevention and care pathways. Although primary prevention remains a crucial step in the prevention of melanoma, the different surveys performed during the last 20 years demonstrate that the use of sunscreen increases very slowly. Secondary prevention that includes skin screening and diagnostic measures may benefit from the development of digital tools. To improve adherence, patients need accurate, reliable information about their disease and the treatment options, and this type of content that can also be made available on digital tools. Shared decision‐making is a hallmark of a patient‐centered approach and requires health care providers who can communicate well to patients and their families, underscoring the pivotal role of health care professionals all through the patient journey. Health care providers have a crucial role in supporting patients through their journey in skin cancer. They will benefit from mobile apps and technologies that have been developed recently to address challenges in skin cancer prevention, detection and care, including those that are primarily directed to the patient. However, more peer‐reviewed studies are needed as well as regulations to ensure that apps are accurate, reliable, and up to date.
Content moderation and advertising in social media platforms
Authors: Madio Leonardo , Quinn Martin 
Published: June 2024

AbstractWe study the incentive of an ad‐funded social media platform to curb the presence of unsafe content that entails reputational risk to advertisers. We identify conditions for the platform not to moderate unsafe content and demonstrate how the optimal moderation policy depends on the risk the advertisers face. The platform is likely to undermoderate unsafe content relative to the socially desirable level when both advertisers and users have congruent preferences for unsafe content and to overmoderate unsafe content when advertisers have conflicting preferences for unsafe content. Finally, to mitigate negative externalities generated by unsafe content, we study the implications of a policy that mandates binding content moderation to online platforms and how the introduction of taxes on social media activity and social media platform competition can distort the platform's moderation strategies.
Environmental heterogeneity structures root‐associated fungal communities in Daphne arbuscula (Thymelaeaceae), a shrub adapted to extreme rocky habitats
Authors: Gajdošová Zuzana , Caboň Miroslav , Kolaříková Zuzana , Sudová Radka , Rydlová Jana , Turisová Ingrid , Turis Peter , Kučera Jaromír , Slovák Marek 
Published: June 2024

AbstractRocky habitats, globally distributed ecosystems, harbour diverse biota, including numerous endemic and endangered species. Vascular plants thriving in these environments face challenging abiotic conditions, requiring diverse morphological and physiological adaptations. Their engagement with the surrounding microbiomes is, however, equally vital for their adaptation, fitness, and long‐term survival. Nevertheless, there remains a lack of understanding surrounding this complex interplay within this fascinating biotic ecosystem. Using microscopic observations and metabarcoding analyses, we examined the fungal abundance and diversity in the root system of the rock‐dwelling West Carpathian endemic shrub, Daphne arbuscula (Thymelaeaceae). We explored the diversification of root‐associated fungal communities in relation to microclimatic variations across the studied sites. We revealed extensive colonization of the Daphne roots by diverse taxonomic fungal groups attributed to different ecological guilds, predominantly plant pathogens, dark septate endophytes (DSE), and arbuscular mycorrhizal fungi (AMF). Notably, differences in taxonomic composition and ecological guilds emerged between colder and warmer microenvironments. Apart from omnipresent AMF, warmer sites exhibited a prevalence of plant pathogens, while colder sites were characterized by a dominance of DSE. This mycobiome diversification, most likely triggered by the environment, suggests that D. arbuscula populations in warmer areas may be more vulnerable to fungal diseases, particularly in the context of global climate change.
Carbon tax revenues and how to spend them: Danes' attitudes toward revenue recycling
Authors: Hedegaard Troels Fage , Kongshøj Kristian 
Published: June 2024

AbstractMany countries are implementing carbon taxation to limit emissions, and this provides a new form of tax revenue. Studies have taken up the question of what forms of expenditure from carbon taxation receive public support and whether ‘revenue recycling’ can improve support for carbon taxation. However, public attitudes are ambiguous. We argue that some of the diverse findings partly reflect that previous studies have lacked the trade‐offs that come with expenditures and that we need to expand focus beyond what the average citizen wants. Therefore, we use an approach where members of the Danish public are asked how they would like to divide the total sum of carbon tax revenues between eight specific areas. We employ hierarchical cluster analysis, which shows a diverse field of groups. This reveals that, while generally popular, expenditures toward climate mitigation and adaptation need to be complemented by social spending to achieve broader support.Related ArticlesIke, Vivian. 2020. “The Impact of Veto Players on Incremental and Drastic Policy Making: Australia's Carbon Tax Policy and Its Repeal.” Politics & Policy 48(2): 232–64. https://doi.org/10.1111/polp.12346.Lachapelle, Erick, Thomas Bergeron, Richard Nadeau, Jean‐François Daoust, Ruth Dassonneville, and Éric Bélanger. 2021. “Citizens' Willingness to Support New Taxes for COVID‐19 Measures and the Role of Trust.” Politics & Policy 49(3): 534–65. https://doi.org/10.1111/polp.12404.Tuxhorn, Kim‐Lee, John D'Attoma, and Sven Steinmo. 2021. “Do Citizens Want Something for Nothing? Mass Attitudes and the Federal Budget.” Politics & Policy 49(3): 566–93. https://doi.org/10.1111/polp.12406.