bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Silver Nitrate Pencils in the Treatment of Common Warts
Authors: Yazar Şahin , Başaran Erdal 
Published: April 2015

AbstractCommon warts are an important issue, especially in children and young adults. The methods proposed for common wart treatment are painful, destructive, and require special experience and devices. The chemical cauterization effect of silver nitrate on warts is noted in the classical pharmaceutical textbooks. In order to test this effect for this purpose, a placebo controlled clinical study was performed on 70 patients.On 35 randomly selected patients, a silver nitrate stick was used, and, on the other 35 patients, black ink was used. At the end of this study, of the patients treated with the silver nitrate stick, 15 (43%) were completely healed, 9 (26%) were partially healed, and 11 (31%) were not healed. Of the patients treated with black ink, 4 (11%) were completely healed, 5 (14%) were partially healed, and 26 (74%) patients were not affected. Thus the silver nitrate stick affected the warts of 24 (69%) patients. Therefore, this method appears to be an effective, economic, and easily applicable treatment for common warts.
Seborrhoeic Dermatitis: Treatment with Anti‐Mycotic Agents
Authors: Sei Yoshihiro , Hamaguchi Taizo , Ninomiya Junya , Nakabayashi Atsuhiro , Takiuchi Iwao 
Published: April 2015

AbstractIn order to elucidate the effectiveness of anti‐mycotics in treating seborrhoeic dermatitis, an attempt was made to isolate Malassezia from seborrhoeic lesions of patients of seborrhoeic dermatitis. The results revealed that, in male patients, 46/49 cases were positive for Malassezia furfur on the face and 30/48 cases were positive for M. furfur on the scalp. In female patients, 7/13 cases were positive for M. furfur on the face, and 6/17 cases were positive for M. furfur on the scalp. Anti‐mycotic agents were excellent in 50% and good in 31% of the spore‐positive cases, yielding an overall efficacy rate of 81%. In contrast, the treatment of the face with vehicle alone showed only one excellent result out of 8 cases. Although clinical improvement was rapid on the side treated with a topical corticosteroid in the half‐side‐test, numerous fungal elements remained. While the improvement with anti‐mycotic agents was slower than that with the corticosteroid, clinical improvement became evident by the third week of administration and fungal elements disappeared.
A Case of Acquired Lymphangioma Due to a Suspected Old Filariasis and a Review of Literature
Authors: Hagiwara Keisuke , Toyama Kensei , Miyazato Hajime , Nonaka Shigeo 
Published: April 2015

AbstractA 65‐year‐old man presented in 1992 with multiple papular lesions on the scrotum and foreskin. His medical history revealed that, at the age of 25, he was diagnosed as having filariasis and treated conservatively at a hospital in Hawaii. The histologic study of the scrotal skin showed large, dilated vascular spaces in the upper dermis lined with a single layer of endothelial cells that were negative for Factor 8‐related antigen. The diagnosis was acquired lymphangioma due to a suspected old filariasis infestation, although serologic tests for filarial antibodies were negative. The paper also presents a review of the literature of acquired lymphangioma in Japan with a brief discussion of etiology and nomenclature.
Psoriasis Is a Visible Manifestation of the Skin's Defense against Micro‐organisms
Authors: Rosenberg E. William , Noah Patricia W. , Skinner Robert B. 
Published: April 2015

AbstractThe recent discovery that human epidermal cells themselves make and secrete the components necessary for activation of the alternative complement pathway appears to provide an explanation for how human skin is ordinarily able to avoid colonization by molds and other organisms. It also helps clarify the mechanisms underlying clinical and laboratory findings seen in chronic mucocutaneous candidiasis, dandruff, and psoriasis. Psoriasis seems best explainable as a visible, late stage of the inflammatory sequelae of activation of the alternative complement pathway in the epidermis.
Bullous Eruption of Systemic Lupus Erythematosus
Authors: Miyagawa Sachiko , Shiomi Yuko , Fukumoto Takaya , Nishikawa Kiyoshi , Ako Hirofumi , Hashimoto Takashi , Shirai Toshihiko 
Published: April 2015

AbstractA bullous eruption is now recognized as a specific complication of systemic lupus erythematosus (SLE). We described a 22‐year‐old woman with SLE whose vesiculobullous eruptions exacerbated with a flare of visceral manifestations of the disease and resolved when the systemic disease was controlled by oral prednisolone.
Annular Elastolytic Giant Cell Granuloma: Response to Cyclosporin A
Authors: Tsutsui Kiyohiro , Hirone Takae , Kubo Katsuhiko , Matsui Yutaka 
Published: April 2015

AbstractA case of annular elastolytic giant cell granuloma with a good response to cyclosporin A is reported. A 62‐year‐old man developed multiple annular patches on the trunk with elevated and indurated borders. Biopsy specimens from the border showed granulomatous inflammation in the mid dermis with phagocytosis of elastic fibers by giant cells. Biopsy specimens from the center showed dense collagen formation without inflammation. Immunological investigation of perivascular infiltrating cells in the lesions revealed a predominance of CD4+ cells over CD8+ cells. Our case showed a good response to cyclosporin A (5 mg/kg/day) for eight weeks. There were no adverse effects and no recurrences for one month after discontinuation of cyclosporin A.
Generalized Vitiligo Preceded by a Generalized Figurate Erythematosquamous Eruption
Authors: Arata Jirô , Abe‐Matsuura Yoshiko 
Published: April 2015

AbstractThe pathogenesis of vitiligo is still unknown. We saw a patient with vitiligo who may support an immunological pathogenesis for this disease. A 77‐year‐old man developed sharply demarcated, irregularly shaped, figurate, erythematosquamous plaques on most of the areas of his body. Histologically, lymphocytic cells invaded the lower epidermis. The lesions were gradually replaced by vitiliginous macules of the same configuration. Histologically, there were no active malanocytes in the vitiliginous lesions. We believe that the present patient presents an extraordinary example of inflammatory vitiligo and may provide an indication of an immunological pathogenesis for vitiligo.
An Evaluation of the Residual Activity of Antiseptic Handrub Lotions: An ‘In Use’ Setting Study
Authors: Namura Shoko , Nishijima Setsuko , Asada Yasuo 
Published: April 2015

AbstractAn evaluation of the residual activity of quick‐drying agents (alcoholic solutions) used for hygienic hand disinfection is described. We looked for residual efficacy following hand disinfection with soap and water alone or followed by one of two alcoholic handrub lotions supplied from an automatic hand washing machine. The bacterial counts on the hands obtained before and within 2 successive hours after disinfection showed that alcoholic chlorhexidine was the most effective for 10 minutes after contamination of the hands. WELPAS® (alcoholic chlorbenzarconium) followed this in its immediate effect and was better than soap and water alone. There were no significant differences after 30‘ or 120‘ between the three disinfecting methods.
Trichilemmal Carcinoma on the Thigh: Report of a Case
Authors: Dekio Satoshi , Funaki Mikio , Jidoi Joji , Mihara Masako 
Published: April 2015

AbstractA 79‐year‐old Japanese man with a trichilemmal carcinoma (TC) on the right thigh is described. To the best of our knowledge, he is the fifth patient with a TC on the thigh reported from Japan.
Gas Gangrene Following Sacral Pressure Sores
Authors: Shibuya Hiromi , Terashi Hiroto , Kurata Sotaro , Ishii Yoshiteru , Takayasu Susumu , Murakami Isamu , Takasaki Syuuji , Nawata Tomoko , Noguchi Takahiro 
Published: April 2015

AbstractWe report two cases of gas gangrene developed from sacral pressure sores. The first case was clostridial and the second, non‐clostridial gas gangrene. Both patients died within two months. The first patient, a 56‐year‐old woman suffering from palsy of the lower half of the body for 3 weeks, developed a sacral pressure sore. One month later, crepitus by palpation and gas formation in the X‐ray film were detected in the hip and right thigh. A culture of odoriferous pus yielded Clostridium limosum in addition to Staphylococcus intermedius, Enterococcus faecalis, Pseudomonas aeruginosa, and Bacteroides fragilis. Blood culture yielded Bacteroides fragilis. The patient died 50 days after admission in spite of surgical debridement and aggressive therapy with high doses of antibiotics and hyperbaric oxygen. The second patient, a 70‐year‐old man suffering from diabetic nephropathy, arteriosclerosis obliterans of the lower limbs, and cerebral infarction, developed a large decubitus ulcer covering the whole sacral area. Crepitus and gas were detected in the soft tissue of the left gluteal region. Almost the entire gluteus maximus muscle was necrotic. Bacteroides fragilis, methicillin‐resistant or ‐sensitive Staphylococcus aureus and Escherichia coli were isolated from the muscle. Bacteroides fragilis was also obtained by blood culture. The patient died on the 72nd day after admission.
Primary Cutaneous Histoplasmosis in Papuloerythroderma (Ofuji)
Authors: Ohnishi Kazunori , Nagai Yayoi , Okada Katsuyuki , Ishikawa Osamu , Miyachi Yoshiki 
Published: April 2015

AbstractWe report the first Japanese patient with primary cutaneous histoplasmosis who was infected inside Japan. He was not an immunocompromised host but his cutaneous lesions developed on preexisting papuloerythroderma (Ofuji). The long‐term topical corticosteroid treatment for papuloerythroderma, which could have suppressed the local immunological defence system of the skin, might have been responsible for the histoplasma infection in the present case.
Effects of Etretinate on Keratinocyte Proliferation and Secretion of Interleukin‐1α (IL‐1α) and IL‐8
Authors: Zhang Jian‐Zhong , Maruyama Kohji , Ono Ichiro , Nihei Yoshimichi , Iwatsuki Keiji , Kaneko Fumio 
Published: April 2015

AbstractEtretinate has proven to be effective in the treatment of psoriasis. Since abnormal proliferation and cytokine secretion are well‐known features of psoriatic epidermis, we studied the in vitro effects of etretinate on these two processes using human keratinocytes. Etretinate promoted proliferation of normal human keratinocytes (NHKs) grown in keratinocyte growth medium (KGM) but not in growth factor‐deficient keratinocyte basic medium (KBM). Moreover, etretinate partly overcame growth inhibition by PMA. Etretinate was shown to have an effect on either IL‐1α or IL‐8 secretion in unstimulated NHKs. In HSC‐1, a human squamous cell carcinoma cell line cultured in 20% FCS/DMEM, inhibited IL‐1α secretion and enhanced IL‐8 secretion. These results indicate that the effects of etretinate on keratinocyte proliferation and cytokine secretion may depend on cell type and culture conditions. Stimulation of NHKs with PMA significantly enhanced IL‐1α and IL‐8 secretion, and these effects were inhibited by etretinate. However, etretinate failed to inhibit rTNFα‐induced IL‐8 secretion, suggesting that etretinate regulation of NHK cytokine secretion may also depend on the stimulus. As treatment of keratinocytes or epidermis with PMA can induce psoriasis‐like changes, so might the experimental “anti‐PMA” activity of etretinate be related to its therapeutic benefit in the treatment of psoriasis.
Factors Responsible for Death in Patients with Pemphigus
Authors: Kanwar Amrinder J. , Dhar Sandipan 
Published: April 2015

AbstractThe records of 10 patients who died with pemphigus have been examined for factors affecting and contributing to death. Early initiation of therapy, the age at onset of the disease, and the mode of administration of corticosteroids, conventional or in pulse form, did not affect the survival. The cutaneous involvement was extensive in all 10 patients; it ranged between 30‐80%. Septicemia was the commonest event preceeding death; in 4 cases, it was due to Staphylococcus aureus.
Nodular Cutaneous Lupus Mucinosis Associated with Atrophie Blanche‐like Lesions in a Patient with Systemic Lupus Erythematosus
Authors: Egawa Hisao , Abe‐Matsuura Yoshiko , Tada Joji , Arata Jirô 
Published: April 2015

AbstractBackgroundMultiple, pale, atrophic depressions surrounded by erythema developed on nodular cutaneous mucinosis lesions in a patient with systemic lupus erythematosus.ObservationsA 22‐year‐old man developed multiple nodular erythematous lesions on the upper arms, back, and chest during the course of systemic lupus erythematosus. Histologically, these nodular lesions were diagnosed as lupus mucinosis. Three years later, the patient began to have atrophic depressed lesions on several nodular mucinosis lesions. These lesions did not develop on normal appearing skin. A biopsy specimen from one of these lesions showed occlusion of blood vessels with thickening of their walls and perivascular dense lymphocytic infiltration. No leukocytoclastic vasculitis was found. Hyaline degeneration was present in some parts of the fatty tissue.ConclusionThe atrophic depressed lesions were atrophie blanche‐like and induced by the vascular occlusion. Since these lesions developed only on the lupus mucinosis lesions, mucin deposition and vascular changes may be closely related.
Nodulocystic Acne: Oral Gugulipid versus Tetracycline
Authors: Thappa Devinder M. , Dogra Jaideep 
Published: April 2015

AbstractTwenty patients with nodulocystic acne were randomly allocated to one of two treatment schedules: 1) Tetracycline 500 mg or 2) Tab. Gugulipid (equivalent to 25 mg guggulsterone). Both were taken twice daily for 3 months, and both produced a progressive reduction in the lesions in the majority of patients. With tetracycline, the percentage reduction in the inflammatory lesions was 65.2% as compared to 68% with gugulipid; on comparison, this difference was statistically insignificant (P>0.05). Follow‐up at 3 months showed a relapse in 4 cases on tetracyline and 2 cases on gugulipid. An interesting observation was that the patients with oily faces responded remarkably better to gugulipid.
Nodular Scleroderma in a Worker Using a Silica‐containing Abrasive
Authors: Yamamoto Toshiyuki , Furuse Yoshiro , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractA patient with progressive systemic sclerosis and high levels of serum IgE developed multiple papules at/on an area of non‐sclerotic skin. Histologic examination of the papule revealed the typical features of scleroderma. For several years, the patient had been working on polishing watches with an abrasive agent composed mainly of aluminum, chromium dioxide, and silica. An association of the abrasive agent, especially of the silica component, with the scleroderma was circumstantially suspected. To the best of our knowledge, this is the first report of nodular scleroderma which occurred in the course of PSS being associated with chemical agents.
Neural Blockade, Urokinase and Prostaglandin E1 Combination Therapy for Acute Digital Ischemia of Progressive Systemic Sclerosis
Authors: Shimizu Yoshiharu , Mizutani Hitoshi , Inachi Shin , Tsuchibashi Tomoko , Shimizu Masayuki 
Published: April 2015

AbstractTo treat severe painful digital ulcers on progressive systemic sclerosis (PSS) patients, we developed a new combination therapy which included neural blockade, intravenous urokinase, and prostaglandin E1 infusion. All of these are already recognized treatments for circulatory disturbances in PSS. Although each of them alone has a limited effect on the painful ischemic attack in PSS; in stepwise combination, neural blockade for release of vascular spasm and pain, prostaglandin E1 for further vasodilatation, and urokinase for thrombolysis were effective in the treatment of digital ischemia in two PSS patients. This therapy reduced the necrotic areas predicted before therapy and saved fingers from amputation. It also relieved the intolerable digital pain and effected the recovery of digital function.
Mid Dermal Elastolysis: Case Report and Review of the Literature
Authors: Agha Amr , Hashimoto Ken , Mahon Michael 
Published: April 2015

AbstractA new case of typical mid dermal elastolysis was studied with electron microscopy. Elastic fibers were irregularly branched or lumpy, but subcomponents of these fibers were often normal. In some fibers, loose assembly of skeleton fibrils and aggregation of dense substances were observed. Phagocytosis of normal and abnormal elastic fibers by dermal macrophages was observed.
Evaluation of the Japanese‐Chinese Herbal Medicine, Kampo, for the Treatment of Lupus Dermatoses in Autoimmune Prone MRL/Mp‐lpr/lpr Mice
Authors: Kanauchi Hideo , Imamura Sadao , Takigawa Masahiro , Furukawa Fukumi 
Published: April 2015

AbstractKampo, a Japanese‐Chinese traditional herbal medicine, has been used for the treatment of various diseases for about 3,000 years in China. Among herbal medicines, Sairei‐to is well known for improving the symptoms of rheumatoid arthritis (RA) and other collagen diseases. However, its immunosuppressive effects on autoimmune cutaneous phenomena are not completely understood. We investigated the effects of Sairei‐to on the development of lupus dermatoses in autoimmune‐prone MRL/Mp‐lpr/lpr (MRL/lpr) mice, an animal model which spontaneously develops skin lesions similar to those seen in human lupus erythematosus. Virgin female MRL/lpr mice at 1 month of age, which were treated orally with Sairei‐to, had reduced amounts of IgG deposition at the dermoepidermal junction, titers of anti‐DNA antibodies and rheumatoid factor, and lymphoproliferation. These results support the use of traditional herbal medicines in patients with human RA and systemic lupus erythematosus.
Proliferating Cell Nuclear Antigen (PCNA) and p53 Protein Expression in Bowen's Disease
Authors: Takata Minoru , Matsui Yutaka 
Published: April 2015

AbstractBowen's disease is a premalignant dermatosis comprised of a clonal proliferation of atypical keratinocytes in the full thickness of the epidermis. To elucidate the relationship between the alteration of the p53 tumor suppressor protein and cell proliferation rate, we immunohistochemically examined the expression of proliferating cell nuclear antigen (PCNA) and p53 protein in 30 cases of Bowen's disease. All the cases exhibited the full‐thickness distribution of PCNA‐positive cycling cells in the lesional epidermis. Quantitation of PCNA staining by image cytometry revealed a mean labeling index (LI) of 75.1 ± 20.3. p53 expression was detected in 13 cases (43%). Expression was diffuse (p53 LI >50) in 9 cases, but focal (p53 LI <30) in the other four. The mean PCNA LI of p53 diffusely positive cases was significantly greater than that of both p53 focally positive and p53 negative cases (89.3 ± 10.1 vs 62.7 ± 21.2, and 70.5 ± 21.6; p<0.01, respectively). These findings suggest that a high‐level accumulation of p53 protein results in a more increased cell proliferation in Bowen's disease.
Oral Florid Papillomatosis and Leukoplakia of the Esophagus Associated with Keratoderma and Showing Transepidermal Elimination
Authors: Ishii Yuko , Sayama Koji , Ohtsuka Hisashi , Shiraishi Satoshi , Miki Yoshiharu 
Published: April 2015

AbstractA 37‐year‐old male presented with a cauliflower‐like tumor in the right buccal mucosa, leukoplakia of the tongue and esophagus, and keratotic papules or plaques on the extremities including bilateral palms and soles, associated with borderline diabetes mellitus and a repeated history of infections. A multi‐system keratinizing abnormality was suspected, although no distinct disease category has been found showing similar involvements.
Immediate Allergy to Rubber Gloves: A Questionnaire Study of Hospital Personnel
Authors: Mizutari Kumiko , Kuriya Norikazu , Ono Tomomichi 
Published: April 2015

AbstractWe conducted a questionnaire study of immediate allergy to natural rubber gloves among 2,408 medical workers who had used rubber gloves at Kumamoto University Hospital and allied hospitals. The response rate was 64.5% (1,321 workers). Among them, 8.5% (7.0–10.0% at 95% confidence limit) replied that they had experienced immediate allergy to rubber gloves. There were significant correlations among the frequency of rubber glove use, a history of atopic dermatitis or contact dermatitis, and the presence of skin lesions due to allergic reactions to rubber gloves. In 27 workers, skin lesions were associated with general symptoms. Of 59 workers who experienced immediate allergy and were tested for latex‐specific IgE, 4 persons were positive. We conclude that the frequency of contact allergy to natural rubber products is substantially prevalent among Japanese hospital personnel and that education and awareness of this allergy are important.
Allergic Granulomatosis (Churg‐Strauss) Associated with Cutaneous Manifestations: Report of Two Cases
Authors: Abe‐Matsuura Yoshiko , Fujimoto Wataru , Arata Jirô 
Published: April 2015

AbstractAllergic granulomatosis (Churg‐Strauss) is sometimes associated with cutaneous manifestations. Biopsies of these manifestations are characteristic enough to allow for the diagnosis of this disease through histological examination. Case 1 involved a 34‐year‐old man who developed a low‐grade fever, blood eosinophilia, paralysis of the right oculomotor nerve, and a polymorphic eruption. In addition, he suffered from preceding asthma and paresthesia of the legs and eventually developed heart failure. The histological examination of a biopsy taken from a hemorrhagic bulla showed a dense perivascular infiltration of eosinophils in the upper dermis and basophilic degeneration of collagen fibers. Case 2 involved a 41‐year‐old man who was afflicted with urticarial erythemas, livedoid erythemas, preceding asthma, and blood eosinophilia. During the course of his illness, he also developed bilateral peroneal nerve paralysis and two small erythemato‐bullous lesions. The histological examination of a urticarial lesion revealed an abundant eosinophil perivascular infiltration; examination of a nodule revealed basophilic degeneration with a granulomatous reaction. Clinical and laboratory studies strongly suggested the diagnosis of allergic granulomatosis in both of these cases. The diagnosis was also supported by a histological examination of the skin lesions.
A Case of Secondary Syphilis with Mucous Patches on the Hard Palate
Authors: Ban Masanori , Ohtani Michihiro , Seishima Mariko 
Published: April 2015

AbstractA rare case of secondary syphilis showing mucous patches on the hard palate is reported. A 31‐year‐old male had two erosive patches which were slightly raised on his hard palate. A linear lesion was also present on the inside of his right alveolar process. Many red‐brown macules on his abdomen and bilateral inguinal lymphadenopathy accompanied these symptoms. The serological tests for syphilis were positive: VDRL test 1:512, TPHA test 1:20,480, and IgM‐FTA‐ABS test 1:40. Immunohistochemical staining with rabbit monoclonal antibody to Treponema pallidum by the biotin‐streptoavidin system detected treponemal organisms in the paraffin‐embedded specimen from his mucous patch. A diagnosis of secondary syphilis was made, and he was given amoxicillin (AMPC) at 750 mg per day for 4 weeks. His eruptions, including the mucous patch, healed in a week.
Malignant Melanoma Developing in an Area of Palmoplantar Keratoderma (Greither's Disease)
Authors: Seike Takuya , Nakanishi Hideki , Urano Yoshio , Arase Seiji 
Published: April 2015

AbstractWe report a case of malignant melanoma arising on the hyperkeratotic sole of a patient with palmoplantar keratoderma (PPK). Hyperkeratotic lesions were also seen on the dorsa of both hands and feet and the extensor aspects of elbows and knees. The patient's PPK appeared to have been transmitted by an autosomal dominant gene. Histologically, the hyperkeratotic lesions showed acanthosis, marked hyperkeratosis without parakeratosis, and hypergranulosis.All the findings corresponded to those of Greither's disease with malignant melanoma.