bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Convenient and Practical Alkynylation of Heteronucleophiles with Copper Acetylides.
Authors: Theunissen Cedric , Lecomte Morgan , Jouvin Kevin , Laouiti Anouar , Guissart Celine , Heimburger Jeremy , Loire Estelle , Evano Gwilherm 
Published: September 2014

AbstractCopper acetylides, activated by oxidation with oxygen in the presence of simple nitrogen ligands, undergo a formal umpolung and are able to transfer their alkyne subunit to a wide range of heteronucleophiles, including amides, oxazolidinones, imines and dialkyl phosphites.
ChemInform Abstract: A Two‐Step Synthesis of the Bioprotective Agent JP4‐039 from N‐Boc‐L‐leucinal.
Authors: Bernardim Barbara , Burtoloso Antonio C. B. 
Published: September 2014

AbstractThe conversion of readily synthesized α,β‐unsaturated diazoketones to β,γ‐unsaturated amides by a photochemical Wolff rearrangement in the presence of primary and secondary amines is presented.
ChemInform Abstract: Aerobic Oxysulfonylation of Alkynes in Aqueous Media: Highly Selective Access to β‐Keto Sulfones.
Authors: Singh Atul K. , Chawla Ruchi , Yadav Lal Dhar S. 
Published: September 2014

AbstractThis simple oxysulfonylation protocol involves the FeCl3/K2S2O8 catalyzed formation of sulfonyl radicals from sulfinate salts.
ChemInform Abstract: Synthesis of C3‐Substituted Enantiopure 2‐(p‐Tolylsulfinyl)‐furans: The Sulfoxide Group as a Chiral Inductor for Furan Dienes as Precursors of a Wide Variety of Chiral Intermediates.
Authors: Montana Angel M. , Grima Pedro M. , Batalla Consuelo , Kociok‐Koehn Gabriele 
Published: September 2014

AbstractA variety of C‐3 functionalized chiral sulfoxide‐containing furan derivatives is prepared, mainly based on manipulation of the carboxyl‐moiety in (III).
ChemInform Abstract: Copper‐Catalyzed Oxidative Cascade Coupling of N‐Alkyl‐N‐phenylacrylamides with Aryl Aldehydes
Authors: Gong Weiwei , Xu Lei , Ji Tao , Xie Ping , Qi Xueyong , Pittman Charles U. Jr. , Zhou Aihua 
Published: September 2014

Abstractfurnishing 3‐(2‐oxo‐2‐arylethyl)indolin‐2‐ones (III) in good yields
ChemInform Abstract: Synthesis and Reactivity of 1,2‐Dioxolanes from β,γ‐Epoxy Ketones.
Authors: Kandur Wynne V. , Richert Kathleen J. , Rieder Curtis J. , Thomas Andrew M. , Hu Chunhua , Ziller Joseph W. , Woerpel K. A. 
Published: September 2014

AbstractA single step acid‐catalyzed addition of H2O2 to β,γ‐epoxy ketones is developed to synthesize hydroperoxy‐substituted 1,2‐dioxolanes as mixture of diastereomers.
ChemInform Abstract: Synthesis of 6‐Aryl Substituted 4‐Quinolones via Suzuki Cross Coupling.
Authors: Gupta Sumanta , Ghosh Prasanjit , Dwivedi Seema , Das Sajal 
Published: September 2014

AbstractThe Suzuki cross coupling of 6‐bromo‐4‐quinolones with arylboronic acids is achieved in the presence of Pd‐carbene complex as catalyst under microwave irradiation to give the corresponding 6‐arylated derivatives.
ChemInform Abstract: Formal Aza‐[3 + 3] versus Aza‐[3 + 2] Cycloadditions of Heterocyclic Enaminones with Maleic Anhydride and Maleimides: Skeletally Diverse Synthesis of Pyrrolizidinones, Indolizidinones, and Pyrroloazepinones.
Authors: Cunha Silvio , Santos Airam Oliveira , Menezes Correia Jose Tiago , Sabino Jose Ricardo 
Published: September 2014

AbstractDomino reactions of cyclic enaminones with maleic anhydride or maleimides are investigated providing the formation of diverse alkaloid‐like products.
ChemInform Abstract: Ce—Zr/SiO2: A Versatile Reusable Heterogeneous Catalyst for Three‐Component Synthesis and Solvent Free Oxidation of Benzyl Alcohol.
Authors: Pagadala Ramakanth , Maddila Suresh , Rana Surjyakanta , Jonnalagadda Sreekantha B. 
Published: September 2014

AbstractCe—Zr loaded on silica is shown to be an extremely efficient catalyst for the synthesis of pyranoquinolines (IV) via a three component reaction as well as the solvent‐free liquid‐phase oxidation of benzyl alcohol.
ChemInform Abstract: Investigation of Ugi‐4CC Derived 1H‐Tetrazol‐5‐yl‐(aryl) Methyl Piperazinyl‐6‐fluoro‐4‐oxo‐1,4‐dihydroquinoline‐3‐carboxylic Acid: Synthesis, Biology and 3D‐QSAR Analysis.
Authors: Chauhan Kuldeep , Singh Pratiksha , Kumar Vikash , Shukla Praveen K. , Siddiqi Mohammad Imran , Chauhan Prem M. S. 
Published: September 2014

AbstractAll compounds are tested for their antibacterial activities.
ChemInform Abstract: Palladium‐Catalyzed Reactions of Allenes with 2‐Iodobenzenesulfonamides: Simple Synthesis of Benzosultams under Green Conditions.
Authors: Nagarjuna Reddy M. , Kumara Swamy K. C. 
Published: September 2014

AbstractBy using allenes (VI) and (VIII) the corresponding β,γ‐cyclized products are obtained as single or major products instead of the β,α‐cyclized ones.
ChemInform Abstract: Novel Synthesis of Thiazolo/Thienoazepine‐5,8‐diones from Dihalo Cyclic 1,3‐Diketones and Mercaptonitrile Salts.
Authors: Luo Laichun , Meng Lanlan , Sun Qi , Ge Zemei , Li Runtao 
Published: September 2014

AbstractThe title compounds are efficiently obtained by domino synthesis of multifunctionalized thiazoles/thiophenes and subsequent intramolecular cyclization.
ChemInform Abstract: Relay Catalysis Using a Gold(I) Complex/Broensted Acid Binary System for the Synthesis of Bezoxasiloles.
Authors: Horino Yoshikazu , Takahashi Yu , Nakashima Yuichi , Abe Hitoshi 
Published: September 2014

AbstractThe novel strategy for the synthesis of benzoxasiloles involves a cascade intramolecular allylation of alkynes and the addition of silanols to enones.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Asymmetric C—H Functionalization/Cyclization Reaction of Metallocenes: An Efficient Approach Toward the Synthesis of Planar Chiral Metallocene Compounds.
Authors: Deng Ruixian , Huang Yunze , Ma Xinna , Li Gencheng , Zhu Rui , Wang Bin , Kang Yan‐Biao , Gu Zhenhua 
Published: September 2014

AbstractThe synthesis of the title compounds is achieved by intramolecular cyclization to form indenone derivatives in high yields with excellent enantioselectivity.
ChemInform Abstract: An Enantioselective Synthesis of the C24—C40 Fragment of (‐)‐Pulvomycin.
Authors: Boerding Sandra , Bach Thorsten 
Published: September 2014

AbstractFragment (I) is prepared in 15 linear steps from D‐fucose in 6.8% overall yield, including a diastereoselective addition to an aldehyde, a β‐selective glycosylation and a Stille cross‐coupling as the key steps.
ChemInform Abstract: Stereoselective Synthesis of Scyphostatin Hydrophilic Moiety.
Authors: Kuwata Kazuaki , Suzuki Masashi , Inami Yoshikazu , Hanaya Kengo , Sugai Takeshi , Shoji Mitsuru 
Published: September 2014

AbstractThe stereoselective synthesis of the title compound (I) is accomplished, which can give access to scyphostatin (II) and its derivatives.
ChemInform Abstract: A Novel Example of Double 6‐exo‐trig Heterocyclization: Nitrile Conversion to New Anticancer Active (HeLa Cells) Primary Amine Ionic Liquids.
Authors: Prodius Denis , Shah Hamid Saeed , Iqbal Jamshed , Macaeva Anastasia , Dimoglo Anatoli , Kostakis George E. , Zill Nicolas , Macaev Fliur , Powell Annie K. 
Published: September 2014

AbstractDerivatives (II) are ionic liquids at room temperature.
ChemInform Abstract: Zintl Phase Compounds AM2Sb2 (A: Ca, Sr, Ba, Eu, Yb; M: Zn, Cd) and Their Substitution Variants: A Class of Potential Thermoelectric Materials
Authors: Guo Kai , Cao Qigao , Zhao Jingtai 
Published: September 2014

AbstractReview: 66 refs.
ChemInform Abstract: Utilization of Acidic α‐Amino Acids as Acyl Donors: An Effective Stereo‐Controllable Synthesis of Aryl‐Keto α‐Amino Acids and Their Derivatives
Authors: Wang Lei , Murai Yuta , Yoshida Takuma , Okamoto Masashi , Tachrim Zetryana Puteri , Hashidoko Yasuyuki , Hashimoto Makoto 
Published: September 2014

AbstractReview: 83 refs.
AgTFSI as p‐Type Dopant for Efficient and Stable Solid‐State Dye‐Sensitized and Perovskite Solar Cells
Authors: Xu Bo , Huang Jing , Ågren Hans , Kloo Lars , Hagfeldt Anders , Sun Licheng 
Published: September 2014

AbstractA silver‐based organic salt, silver bis(trifluoromethane‐sulfonyl)imide (AgTFSI), was employed as an effective p‐type dopant for the triarylamine‐based organic hole‐transport material Spiro‐MeOTAD, which has been successfully applied in solid‐state dye‐sensitized solar cells (ssDSCs) and perovskite solar cells (PSCs). The power conversion efficiencies (PCEs) of AgTFSI‐doped devices improved by 20 %, as compared to the device based on the commonly used oxygen doping both for ssDSCs and PSCs. Moreover, the solid‐state dye‐sensitized devices exposed to AgTFSI as dopant showed considerably better stability than those of oxygen doped, qualifying this p‐type dopant as a promising alterative for the preparation of highly efficient as well as stable ssDSCs and PSCs for the future.
Electrochemical Sensing of Uric Acid Using Glassy Carbon Modified with Multiwall Carbon Nanotubes Dispersed in Polyethylenimine
Authors: Gutiérrez Alejandro , Lozano Maria L. , Galicia Laura , Ferreyra Nancy F. , Rivas Gustavo A. 
Published: September 2014

AbstractThis work reports the advantages of using glassy carbon electrodes modified with multiwall carbon nanotubes (MWCNT) dispersed in polyethylenimine (PEI). The presence of MWCNTs wrapped by PEI largely facilitated the strong adsorption of uric acid (UA) and allowed its highly sensitive and selective quantification even in the presence of high excess of ascorbic acid. The selected conditions for the electrochemical sensing were 5 s accumulation at −0.300 V under stirring and quantification in a 0.050 M phosphate buffer solution pH 7.40 by differential pulse voltammetry adsorptive‐stripping after medium exchange. The platform allowed the successful application in the quantification of UA in urine.
Characteristics of some synthetic terpenoids with a grapefruit odour discovered by serendipity
Authors: Bonikowski Radosław , Świtakowska Paulina , Jabłońska Aneta , Kula Józef , Sienkiewicz Monika , Gabrysiak Justyna , Kajrukszto Krzysztof 
Published: September 2014

ABSTRACTThis work presents odour characteristics of a newly synthesized family of seven terpenoid alcohols with citrusy grapefruit odours. The alcohols were prepared from citronellal that was subjected to a two‐ or three‐step reaction sequence to deliver secondary or tertiary alcohols. Two other compounds with an acetal structure (containing 18 and 19 carbon atoms) with the same odour type and very high tenacity were synthesized from (+)‐3‐carene. The most olfactorily potent compounds were 5,9‐dimethyldec‐8‐en‐2‐ol 10 and 2‐carene derivative acetal 25. Copyright © 2014 John Wiley & Sons, Ltd.
Neural substrates of approach‐avoidance conflict decision‐making
Authors: Aupperle Robin L. , Melrose Andrew J. , Francisco Alex , Paulus Martin P. , Stein Murray B. 
Published: September 2014

AbstractAnimal approach‐avoidance conflict paradigms have been used extensively to operationalize anxiety, quantify the effects of anxiolytic agents, and probe the neural basis of fear and anxiety. Results from human neuroimaging studies support that a frontal–striatal–amygdala neural circuitry is important for approach‐avoidance learning. However, the neural basis of decision‐making is much less clear in this context. Thus, we combined a recently developed human approach‐avoidance paradigm with functional magnetic resonance imaging (fMRI) to identify neural substrates underlying approach‐avoidance conflict decision‐making. Fifteen healthy adults completed the approach‐avoidance conflict (AAC) paradigm during fMRI. Analyses of variance were used to compare conflict to nonconflict (avoid‐threat and approach‐reward) conditions and to compare level of reward points offered during the decision phase. Trial‐by‐trial amplitude modulation analyses were used to delineate brain areas underlying decision‐making in the context of approach/avoidance behavior. Conflict trials as compared to the nonconflict trials elicited greater activation within bilateral anterior cingulate cortex, anterior insula, and caudate, as well as right dorsolateral prefrontal cortex (PFC). Right caudate and lateral PFC activation was modulated by level of reward offered. Individuals who showed greater caudate activation exhibited less approach behavior. On a trial‐by‐trial basis, greater right lateral PFC activation related to less approach behavior. Taken together, results suggest that the degree of activation within prefrontal‐striatal‐insula circuitry determines the degree of approach versus avoidance decision‐making. Moreover, the degree of caudate and lateral PFC activation related to individual differences in approach‐avoidance decision‐making. Therefore, the approach‐avoidance conflict paradigm is ideally suited to probe anxiety‐related processing differences during approach‐avoidance decision‐making.Hum Brain Mapp 36:449–462, 2015. ©2014 Wiley Periodicals, Inc.
The role of rituximab and positron emission tomography in the treatment of primary mediastinal large B‐cell lymphoma: experience on 74 patients
Authors: Zinzani Pier Luigi , Broccoli Alessandro , Casadei Beatrice , Stefoni Vittorio , Pellegrini Cinzia , Gandolfi Letizia , Maglie Roberto , Argnani Lisa , Pileri Stefano , Fanti Stefano 
Published: September 2014

AbstractRegarding primary mediastinal large B‐cell lymphoma (PMLBCL), there are several controversial topics that warrant further investigation: the superiority of third‐generation regimens, the impact of rituximab, the use of involved field radiotherapy (RT) and the assessment of clinical response by positron emission tomography (PET). We report our experience on 74 PMLBCL patients treated with a combination of a third‐generation chemotherapy regimen (MACOP‐B) and rituximab: an observational retrospective single‐centre study was conducted on patients diagnosed and treated between February 2002 and July 2011. All patients were evaluated by computed tomography scan and PET scan; after the final PET evaluation, PET‐negative patients were observed, whereas PET‐positive patients underwent mediastinal RT. Sixty‐one (82.4%) patients achieved a complete response after the MACOP‐B plus rituximab regimen; 68.9% presented a positive final PET and were treated with local RT, whereas 31.1% had a negative PET. Five patients relapsed within 12 months. At 10 years, overall survival was 82%, progression‐free survival was 87.6% and disease‐free survival (DFS) was 90.5% (median follow‐up 4 years). No statistically significant differences were observed in DFS between the patients treated also with RT (PET positive) and patients only observed (PET negative): 90.7% vs 90% (p = 0.85), respectively. In our experience, adding rituximab does not change the final results in terms of complete response and DFS utilizing third‐generation regimen. Furthermore, the introduction of the PET‐guided RT approach leads to a patient‐tailored treatment, which preserves the outcome and, at the same time, allows reducing the use of RT. Copyright © 2014 John Wiley & Sons, Ltd.
Nano‐textured fluidic biochip as biological filter for selective survival of neuronal cells
Authors: Han Hsieh‐Cheng , Lo Hung‐Chun , Wu Chia‐Yu , Chen Kuei‐Hsien , Chen Li‐Chyong , Ou Keng‐Liang , Hosseinkhani Hossein 
Published: September 2014

AbstractThis is an innovative study to engineer biological filter to evaluate the effect of template surface structure and physiochemical properties that can be used for wide variety of applications in biological, health care as well as environmental protection. Specifically, planar silicon (Si) wafer and arrayed Si nano‐tips (SiNT) templates were fabricated and coated with gold for various lengths of time to study the effect of surface charge, surface roughness, and hydrophilicity on biological activity of rat pheochromocytoma cell lines PC12. The initial growth and proliferation of PC12 cells on Si and SiNT templates showed an antipathy for the ultra‐sharp SiNTs templates. In contrast, the same cells demonstrated a preferable adherence to and proliferation on planar Si templates, resulting in higher cell densities by three orders of magnitude than those on SiNT templates. It is hypothesized that SiNTs array does generate nano‐fluidic effect such that the effective contact region for aqueous solution on SiNTs is lower than that on planar Si templates, thus decreasing adsorbable area for cell viability and survival. Moreover, the effect of the gold coating on cell number density was analyzed in terms of the surface roughness, zeta potential and wetting properties of the templates. It was determined that surface charge, as measured by the zeta potential, strongly correlated with the trend observed in the surface cell density, whereas no such correlation was observed for surface roughness or wetting properties in the ranges of our experiment conditions. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2015–2023, 2015.
Tailoring of the dopamine coated surface with VEGF loaded heparin/poly‐l‐lysine particles for anticoagulation and accelerate in situ endothelialization
Authors: Liu Yang , Zhang Jiang , Wang Jian , Wang Yuan , Zeng Zheng , Liu Tao , Chen Junying , Huang Nan 
Published: September 2014

AbstractCoronary artery disease is a great threat to human health and is the leading killer worldwide. Percutaneous coronary intervention is the most effective therapy; however, thrombus, and restenosis caused by endothelium injury continue to be problematic after treatment. It is widely accepted that surface biofunctional modification to improve blood compatibility and accelerate endothelialization may be an effective approach to prevent the occurrence of adverse cardiac events. In this study, novel VEGF‐loaded heparin/poly‐l‐lysine (Hep/PLL) particles were developed and immobilized on a dopamine coated titanium surface. The size, distribution, zeta potential, and morphology of the prepared particles were subsequently characterized. The influence of changes in the surface physicochemical properties after particle immobilization was assessed for blood compatibility and cytocompatibility. Surface‐modified VEGF‐loaded particles significantly inhibited platelet adhesion and activation and were effective in promoting the proliferation and survival of endothelial progenitor cells and endothelial cells. Moreover, Hep/PLL particles were also beneficial for controlling the long‐term release of VEGF, which may facilitate endothelium regeneration. In conclusion, VEGF‐loaded Hep/PLL particles were successfully immobilized on the Ti surface, and the biocompatibility was significantly improved. This study demonstrates a potential application for the multifunctional modification of stent surfaces for clinical use. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2024–2034, 2015.
The effect of extracellular matrix proteins on the cellular response of HUVECS and HOBS after covalent immobilization onto titanium
Authors: Heller Martin , Kämmerer Peer W. , Al‐Nawas Bilal , Luszpinski Marie‐Anne , Förch Renate , Brieger Jürgen 
Published: September 2014

AbstractBiomimetic surface modifications are regarded as promising approach to stimulate cellular behavior at the interface of implant materials. Aim of the study was an evaluation of the cellular response of human umbilical cord cells (HUVECS) and human osteoblasts (HOBS) on titanium covalently coated with the extracellular matrix (ECM) proteins fibrinogen, collagen, laminin, and osteopontin. For the surface modification, titanium discs were first amino‐functionalized by plasma polymerization of allylamine. The ECM protein conjugation was performed using the linker molecule α, ω‐bis‐N‐hydroxysuccinimide polyethylene glycol (Di‐NHS linker). For surface characterization, infrared spectroscopy and fluorescein isothiocyanate staining (FITC) were used to evaluate the presence and distribution of primary amines in the plasma polymer film. Real‐time analyses of the respective protein conjugation processes were performed via surface plasmon resonance kinetic measurements. All ECM proteins were immobilized successfully. Furthermore, the biological functionality of the conjugated factors fibronectin and collagen could be proven as they led to a distinct stimulation of cell adhesion of HUVECS and HOBS when compared to the control group. The highest cell coverage of HUVECS was observed on fibronectin‐modified surfaces with approximately 35% and on collagen with 33% after 24 h (PT: 9.4%). For laminin, no additional effect was observed, and for osteopontin, only a slight enhancement of cell adhesion was found. A similar, cell‐stimulating tendency of fibronectin and collagen was seen as well after 3 and 7 days. Biomimetic surface modification via plasma polymerization is a powerful method for biomolecule conjugation with a high retention of biological functionality and offer promising clinical perspectives. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2035–2044, 2015.
Evaluation of the Effectiveness of Forest Restoration and Check‐Dams to Reduce Catchment Sediment Yield
Authors: Quiñonero‐Rubio Juan Manuel , Nadeu Elisabet , Boix‐Fayos Carolina , de Vente Joris 
Published: September 2014

AbstractReforestations and check‐dams are two commonly used measures to reduce soil erosion rates and sediment export from highly eroding catchments. Here, we evaluated the impact of the construction of 94 check‐dams and land use changes (caused by agricultural abandonment and reforestations) on sediment yield in the Upper Taibilla catchment (320 km2, SE Spain) from 1956 to 2000. We combined land use change analysis, field surveys, and application of the WaTEM‐SEDEM erosion and sediment yield prediction model for nine scenarios combining land use maps (1956, 1987, and 2000) and different numbers of check‐dams throughout the catchment. Land use changes alone reduced sediment yield up to 14%, but in combination with check‐dams, the reduction in sediment yield reached 44 ± 6%. Sediment yield reduction was higher in smaller sub‐catchments, with, on average, a higher transport capacity than larger catchments, illustrating the scale dependency of human impacts on sediment fluxes and the buffer capacity of larger catchments. From an economical perspective, the construction of check‐dams was estimated to be more expensive than reforestation programs in the studied catchment, while adding more check‐dams did not always result in a proportional reduction of sediment yield. This indicates that optimizing check‐dam distribution relative to land use patterns is crucial to decrease catchment sediment yield. Check‐dams have a large and instantaneous impact on sediment yield over a restricted time period, while reforestations have important sustained effects at a lower economic cost. These contrasting effects require a careful evaluation for optimal effective catchment management. Copyright © 2014 John Wiley & Sons, Ltd.