bluuebunny/crossref_metadata_2025_split huggingface dataset:
Education for responsible persons, tourists and hosts through knowledge of neighbouring countries' languages in cross-border areas
Authors: Brumen Mihaela , Cagran Branka , Mulej Matjaž 
Published: March 2014

Purpose
– The presented study aims to address the subject of educating youngsters in cross-border regions to be responsible persons, tourists, hosts and neighbours, to accept cultural pluralism, and to raise awareness that knowledge of neighbouring countries' languages supports cross-border cooperation.

Design/methodology/approach
– The approach double-checked theory and legal regulation, and children's knowledge of neighbouring countries' (Slovenia, Hungary, Austria, and Croatia) languages was empirically researched. Indirectly, parental attitudes were examined. The study focused on Slovene and Hungarian languages and on their trans-border (or: cross-border) tourism as a cultural rather than economic topic.

Findings
– Cross-border tourism depends also on mutual understanding as a precondition of ethics of interdependence as a precondition of the requisite holism of one's approach via social responsibility enabling the well-being of both tourists and hosts. The socio-linguistic and socio-cultural aspects of neighbouring regions, e.g. Slovenia's Prekmurje and Hungary's Örseg, can support positive interaction between ethnic groups and enhance effective cross-border collaboration, including tourism. Poor knowledge of neighbouring countries' languages submits communities to third languages and hinders these trans-border experiences, making the regions a shared destiny maintaining their cultures, languages and identity. Language learning therefore must start at the earliest possible age.

Originality/value
– This case study advocates cross-border educational and cultural policy that (primary) schools should increase the awareness of the dependence of cross-border peace, positive stereotypes, economies and tourism on knowledge of neighbouring countries' languages and socially responsible (young/future) persons, tourists and hosts.
Development controls in the Offinso South municipality, Ghana
Authors: Addai Boamah Nicholas 
Published: March 2014

Purpose
– The purpose of this paper is to examine the system of development controls in the Offinso South municipality. It investigates the challenges to the development control regime.

Design/methodology/approach
– The paper reviews the land use regulation system in the municipality. The municipality was clustered into four for data collection. Eight neighbourhoods (two from each cluster) were selected from the municipality for the study. In all, 15 properties were sampled via purposive sampling techniques from each of the selected neighbourhoods for data gathering. Self-administered questionnaires were relied on to gather data from the 120 respondents. The property owners were the unit of enquiry.

Findings
– The paper finds that socio-cultural factors, delays in the planning approval process, negative public perceptions about the planning process and planning officials, lack of official support to developers in curing identified defects in their proposed developments, and unrealistic building regulations are partly responsible for the large-scale violations of development controls in the municipality.

Practical implications
– It is noted that the planning authority should focus more on strategies that will facilitate voluntary compliance and less on enforcement. It also notes the need for a review of the building regulations and the purging of the planning system from negative public perceptions and processing delays.

Originality/value
– The paper identifies the constraints on the Ghanaian development controls regime.
Shadowing and Consensus Building: a golden bridge
Authors: Sclavi Marianella 
Published: March 2014

Purpose– Much of what the author want to say in this paper had to do with “control” “exactness,” “precision” and their declination in both: shadowing and Consensus Building Approach. The purpose of this paper is to discuss these issues.Design/methodology/approach– This paper upholds two things: first, that shadowing is a field technique particularly attuned to action research as defined by Chris Argyris: “I would summarize [action-research and action-science] by saying that Kurt Lewin did three things: he was committed to understanding reality as the participants understood it, he used a combination of so-called ‘normal’ science with a narrative-integrative approach, and he tested his ideas by trying to change the things that he was studying.”Findings– Second, that the results of such a research are best understood by the organization's management when the interpretation and decision process follow an approach based on active listening and an inclusive participatory methodology such as Consensus Building.Originality/value– When this does not happen, the shadowing methodology allows a very rich research experience with no real impact on the organization's life.
Shadowing research in organizations: the methodological debates
Authors: McDonald Seonaidh , Simpson Barbara 
Published: March 2014

Purpose
– The purpose of this paper is to provide some context for the special issue and to introduce the collection of invited commentaries and research papers that follow. It also sets out to clarify the contribution that shadowing methods can make to the study of organizations.

Design/methodology/approach
– This is done by briefly outlining the ways in which shadowing methods have developed in parallel within a number of disciplines. In order to tackle the question of why this has happened, a grounded approach is taken which centres on data excerpts generated by a shadowing method and three of its closest methodological neighbours: interviews, observation and participant observation. The paper further develops this analysis through the presentation of a set of illustrative analogies which use the idea of the researcher's gaze as a beam of light.

Findings
– Similarities and differences between shadowing, interviews, observation and participant observation are identified, which support the articulation of shadowing as a family of following methods.

Research limitations/implications
– Taken together, the contributions from the invited commentaries and research papers, suggest a number of ways in which the debate surrounding shadowing research in organizations needs to be developed going forward.

Originality/value
– The reflexive, comparative methodological approach taken here provides for the first time a systematic comparison of shadowing in relation to other common qualitative data elicitation methods. Further, the development of a critique of the extant literature on shadowing provides a basis on which to progress the field, both in terms of shadowing practices themselves and writing about them within disciplines and across the research methods literature.
Not for the faint of heart
Authors: Urban Ann-Marie , Quinlan Elizabeth 
Published: March 2014

Purpose– The purpose of this paper is to share two researcher's experience about the challenges associated with shadowing within the health care context.Design/methodology/approach– Institutional ethnography and shadowing.Findings– Shadowing is increasingly being used as a data collection method, however, before proceeding to use this approach in today's health care environment, the researcher must give thoughtful consideration to the context.Originality/value– This paper provides a reflexive elaboration of the differences between the insider and outsider perspective when using the shadowing data collection method within health care organizations.
Sustainable integrity: how reverse auctions can benefit suppliers in emerging markets
Authors: G. Hawkins Timothy , S. Randall Wesley , V. Coyne Adam , H. Baitalmal Mohammad 
Published: March 2014

Purpose
– The growth of international business persists, particularly in emerging economies. Business in these developing nations is heavily influenced by national culture. In the Middle East and North Africa (MENA) region, buyer-supplier relationships are often negatively influenced by “wasta” – a term associated with power, influence, connection and corruption. Technology-enhanced business processes diffuse as globalization increases. The purpose of this research was to explore whether and, if so, how electronic reverse auction (e-RA) use might be effective in a MENA national culture.

Design/methodology/approach
– The authors use a case study method based on data collected from 13 interviews with supply chain members extending beyond the dyad to explain: why Middle Eastern bidders participated in an e-RA; the nature of a unique phenomenon in Middle Eastern culture called wasta; and (3) how wasta, e-RA use, and procurement integrity interact in a sustainable way.

Findings
– This case study extends knowledge in the area of global supply chain management by identifying new opportunities and providing a mechanism to ameliorate risks. It demonstrated that e-RAs can ameliorate some of the deleterious effects of wasta by increasing transparency and procedural fairness associated with MENA-based buyer-supplier relationships.

Originality/value
– E-RAs have been criticized as being unfair to suppliers. This study unveils cultural idiosyncrasies where e-RAs overcome a moral hazard associated with MENA buyer-supplier relationships and become a supplier's favored sourcing medium. As economic growth in MENA is expected to outpace all other regions, this study has implications for understanding how regionally specific cultural variables impact B2B sourcing strategy adoption and outcomes.
Application of Micro‐Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy to Ink Examination in Signatures Written with Ballpoint Pen on Questioned Documents
Authors: Nam Yun Sik , Park Jin Sook , Lee Yeonhee , Lee Kang‐Bong 
Published: March 2014

AbstractQuestioned documents examined in a forensic laboratory sometimes contain signatures written with ballpoint pen inks; these signatures were examined to assess the feasibility of micro‐attenuated total reflectance (ATR) Fourier transform infrared (FTIR) spectroscopy as a forensic tool. Micro‐ATR FTIR spectra for signatures written with 63 ballpoint pens available commercially in Korea were obtained and used to construct an FTIR spectral database. A library‐searching program was utilized to identify the manufacturer, blend, and model of each black ballpoint pen ink based upon their FTIR peak intensities, positions, and patterns in the spectral database. This FTIR technique was also successfully used in determining the sequence of homogeneous line intersections from the crossing lines of two ballpoint pen signatures. We have demonstrated with a set of sample documents that micro‐ATR FTIR is a viable nondestructive analytical method that can be used to identify the origin of the ballpoint pen ink used to mark signatures.
Optimization of Human mtDNA Control Region Sequencing for Forensic Applications
Authors: Bourdon Véronique , Ng Carolyn , Harris Jessica , Prinz Mechthild , Shapiro Eli 
Published: March 2014

AbstractSequencing mitochondrial DNA hypervariable regions I and II (HVI and HVII) is useful in forensic missing person and unidentified remains cases. Improvements in ease and sensitivity of testing will yield results from more samples in a timely fashion. Routinely, amplification of HVI and HVII is followed by Sanger sequencing using the BigDye® Terminator v3.1 Cycle Sequencing kit (Applied Biosystems) using 4 μL of ready reaction mix (RRM). Each sequencing reaction is then purified through column filtration before capillary electrophoresis. Using lower amounts of RRM (2 μL or 1 μL) and purification using BigDye® XTerminator™ (Applied Biosystems) instead of columns showed no loss of sequence length and increased the quality and the sensitivity of testing, allowing HVI and HVII typing from mitochondrial genome equivalent to 125 fg of nuclear DNA, or 100 pg of HVI/HVII amplicons. Using this methodology, testing can be completed in 1 day, and the cost of testing is reduced.
Detection of Denatonium Benzoate (Bitrex) Remnants in Noncommercial Alcoholic Beverages by Raman Spectroscopy
Authors: Kwiatkowski Andrzej , Czerwicka Małgorzata , Smulko Janusz , Stepnowski Piotr 
Published: March 2014

AbstractIllegal alcoholic beverages are often introduced into market using cheap technical alcohol, which is contaminated by denatonium benzoate (Bitrex) of very small concentration. Bitrex is the most bitter chemical compound and has to be removed before alcohol consumption. The home‐made methods utilize sodium hypochlorite to disintegrate particles of denatonium benzoate in alcohol and to remove bitter taste before trading. In this experimental studies, we propose a novel method that detects in a fast way the remnants of denatonium benzoate in dubious alcohol samples by Raman spectroscopy. This method applies a portable Raman spectrometer of excitation wavelength 785 nm and utilizes the effect of surface‐enhanced Raman spectroscopy (SERS) to recognize the suspected alcoholic beverages. High effectiveness (over 98%) of YES/NO classification of the investigated samples was observed when the nonlinear algorithm support vector machine (SVM) was exploited at carefully adjusted detection parameters. The method can identify illicit alcohol within minutes.
Modeling the Fate of Escherichia coli O157:H7 and Salmonella enterica in the Agricultural Environment: Current Perspective
Authors: Ongeng Duncan , Haberbeck Leticia U. , Mauriello Gianluigi , Ryckeboer Jaak , Springael Dirk , Geeraerd Annemie H. 
Published: March 2014

AbstractThe significance of fresh vegetable consumption on human nutrition and health is well recognized. Human infections with Escherichia coli O157:H7 and Salmonella enterica linked to fresh vegetable consumption have become a serious public health problem inflicting a heavy economic burden. The use of contaminated livestock wastes such as manure and manure slurry in crop production is believed to be one of the principal routes of fresh vegetable contamination with E. coli O157:H7 and S. enterica at preharvest stage because both ruminant and nonruminant livestock are known carriers of E. coli O157:H7 and S. enterica in the environment. A number of challenge‐testing studies have examined the fate of E. coli O157:H7 and S. enterica in the agricultural environment with the view of designing strategies for controlling vegetable contamination preharvest. In this review, we examined the mathematical modeling approaches that have been used to study the behavior of E. coli O157:H7 and S. enterica in the manure, manure‐amended soil, and in manure‐amended soil–plant ecosystem during cultivation of fresh vegetable crops. We focused on how the models have been applied to fit survivor curves, predict survival, and assess the risk of vegetable contamination preharvest. The inadequacies of the current modeling approaches are discussed and suggestions for improvements to enhance the applicability of the models as decision tools to control E. coli O157:H7 and S. enterica contamination of fresh vegetables during primary production are presented.
Incidence and clinical implication of tumor cavitation in patients with advanced non‐small cell lung cancer induced by Endostar, an angiogenesis inhibitor
Authors: Huang Chun , Wang Xuan , Wang Jing , Lin Li , Liu Zhujun , Xu Wenjing , Wang Liuchun , Xiao Jianyu , Li Kai 
Published: March 2014

AbstractBackgroundAntiangiogenesis plays a key role in the treatment of non‐small lung cancer (NSCLC). We observed the cavitation of lesions in patients with stage IIIB/IV NSCLC treated with Endostar and vinorelbine‐cisplatin (NP) chemotherapy, and evaluated the imaging characteristics and clinical outcome of patients who developed tumor cavitation.MethodsOur study included 105 untreated NSCLC patients who received Endostar in combination with NP chemotherapy at the Tianjin Lung Cancer Center. Chest computed tomography (CT) was performed to evaluate the efficacy every two cycles. The number of activated circulating endothelial cells (aCECs) was measured by flow cytometry. Rates of tumor cavitation were documented and their clinical CT imaging data were analyzed.ResultsTumor cavitation occurred in 11 of the 105 (10.5%) patients treated with Endostar and NP. The response rates were 37.2% (35/94) in patients without cavitation, 27.3% (3/11) evaluated by Response Evaluation Criteria in Solid Tumors, and 100.0% (11/11) if evaluated by an alternate method in patients who developed cavitation. Three of the 11 cases with cavitation had a centrally located tumor. No patients had hemoptysis or any other severe side effects. Compared with patients not developing cavitation, cavity formation resulted in a longer median survival time (13.6 vs. 11.8 months, P = 0.011) and an increase in the number of aCECs (244.4/105 vs. 23.3/105, P = 0.000).ConclusionsIntratumoral cavitation induced by Endostar is common in NSCLC patients, and is not correlated with squamous histology, tumor location or pulmonary hemorrhage. Cavitation might have a significant effect on the number of aCECs and overall prognosis.
A polymorphism in XKR4 is significantly associated with serum prolactin concentrations in beef cows grazing tall fescue
Authors: Bastin B. C. , Houser A. , Bagley C. P. , Ely K. M. , Payton R. R. , Saxton A. M. , Schrick F. N. , Waller J. C. , Kojima C. J. 
Published: March 2014

SummaryFescue toxicosis is a common syndrome of poor growth and reproductive performance of beef cattle grazing endophyte‐infected tall fescue infected with Lolium arundinaceum Schreb. Together with decreased feed intake, decreased growth rates and tissue necrosis due to vasoconstriction, depressed circulating serum prolactin concentrations are typically observed in cattle afflicted with fescue toxicosis. Polymorphisms within the XK, Kell blood group complex subunit‐related family, member 4 (XKR4) gene located on BTA14 have been previously reported to be associated with rump fat thickness, residual feed intake, average daily feed intake and average daily gain in cattle. Associations also have been reported between XKR4 genotype and effectiveness of the dopamine antagonist iloperidone as a treatment of schizophrenia in humans. Domperidone, a related dopamine antagonist, mediates effects of fescue toxicosis on livestock, including restoring depressed concentrations of prolactin. A mixed‐breed population of 592 beef cattle grazing endophyte‐infected tall fescue was used to examine the association between XKR4 genotype and circulating prolactin concentrations. The SNP rs42646708 was significantly (P = 0.0002) associated with serum prolactin concentrations and explained 2.45% of the phenotypic variation. Effect of genotype at the SNP was tested across five breeds, with significant associations within both Angus (P = 0.0275) and Simmental (P = 0.0224) breeds. These results suggest XKR4 may play a role in mediating the negative effects of fescue toxicosis, and polymorphisms within this gene may be useful markers for selection for genetic resistance to the debilitating effects of endophyte‐infected tall fescue.
A common atopy‐associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding
Authors: Kretschmer A. , Möller G. , Lee H. , Laumen H. , von Toerne C. , Schramm K. , Prokisch H. , Eyerich S. , Wahl S. , Baurecht H. , Franke A. , Claussnitzer M. , Eyerich K. , Teumer A. , Milani L. , Klopp N. , Hauck S. M. , Illig T. , Peters A. , Waldenberger M. , Adamski J. , Reischl E. , Weidinger S. 
Published: March 2014

AbstractBackgroundType 2 immune responses directed by Th2 cells and characterized by the signature cytokines IL4, IL5, and IL13 play major pathogenic roles in atopic diseases. Single nucleotide polymorphisms in the human Th2 cytokine locus in particular in a locus control region within the DNA repair gene RAD50, containing several RAD50 DNase1‐hypersensitive sites (RHS), have been robustly associated with atopic traits in genome‐wide association studies (GWAS). Functional variants in IL13 have been intensely studied, whereas no causative variants for the IL13‐independent RAD50 signal have been identified yet. This study aimed to characterize the functional impact of the atopy‐associated polymorphism rs2240032 located in the human RHS7 on cis‐regulatory activity and differential binding of transcription factors.MethodsDifferential transcription factor binding was analyzed by electrophoretic mobility shift assays (EMSAs) with Jurkat T‐cell nuclear extracts. Identification of differentially binding factors was performed using mass spectrometry (LC‐MS/MS). Reporter vector constructs carrying either the major or minor allele of rs2240032 were tested for regulating transcriptional activity in Jurkat and HeLa cells.ResultsThe variant rs2240032 impacts transcriptional activity and allele‐specific binding of SMAD3, SP1, and additional putative protein complex partners. We further demonstrate that rs2240032 is located in an RHS7 subunit which itself encompasses repressor activity and might be important for the fine‐tuning of transcription regulation within this region.ConclusionThe human RHS7 critically contributes to the regulation of gene transcription, and the common atopy‐associated polymorphism rs2240032 impacts transcriptional activity and transcription factor binding.
Analysis of 35 cases of Xanthogranulomatous pyelonephritis
Authors: Addison Ben , Zargar Homayoun , Lilic Nikola , Merrilees David , Rice Michael 
Published: March 2014

AbstractBackgroundTo retrospectively determine key demographic and clinical features of 35 patients with Xanthogranulomatous pyelonephritis (XGP) in a New Zealand setting and to compare it with the existing literature.MethodsA retrospective review of patients having a confirmed diagnosis of XGP on histopathology examination was performed. Key clinical and demographic features were analysed and compared with the published literature.ResultsXGP was diagnosed in 35 patients over a 12‐year (2001–2013) period in Auckland Public Hospital. Ninety‐one percent of the patients were female. The population had significantly higher numbers of Maori and Pacific Island patients compared with the general population (74%). Staghorn calculi were the most common cause (51.4%) with obstructing ureteric calculi as the next most common (22.9%) cause. Twenty percent of cases were not thought to be XGP prior to nephrectomy (suspicious renal mass). Thirteen (38%) patients suffered serious complications post‐operatively (Clavien 3–5).ConclusionXGP is a rare chronic inflammatory condition that appears to be overrepresented by Maori and Pacific islanders in our cohort when compared with the overall patient pool. Surgical treatment is associated with significant morbidity but remains the only definitive option. Obesity and other conditions associated with metabolic syndrome may coexist at the time of presentation and may be contributing factors to the development of XGP and poor outcomes associated with it.