bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simulation-optimization approach for assessing optimal wastewater load allocation schemes in the Three Gorges Reservoir, China
Authors: Wang Zheng , Cheng Shuiyuan , Liu Lei , Guo Xiurui , Chen Yuan , Qin Cuihong , Hao Ruixia , Lu Jin , Gao Jijun 
Published: January 2014

Abstract

Background
The Three Gorges Reservoir (TGR) has been facing deteriorated water quality issues since the construction of the Three Gorges Dam (TGD) in 1994. However, no previous studies have used a simulation-optimization assessment framework to examine the waste-load allocation patterns in the TGR area for alleviating its water pollution problem. In this study, a simulation-optimization modeling approach was developed for addressing this issue, through combining an environmental fluid dynamic code (EFDC)-based water quality simulation model and a waste-load allocation optimization model into a general framework.

Results
The approach was applied to a TGR section (Changshou-Fuling section) for identifying the optimal waste-load allocation schemes among its 11 wastewater discharge outlets. Firstly, the EFDC model was run to simulate the water quality response in the receiving water body under a single discharge load scenario, and the simulated COD and NH4
+-N concentrations were used to calculate the pollution mixing zone (PMZ), the pollution mixing zone per unit load (PMZPL), and sensitivity index (SI) pertaining to that outlet. These values were then used in the formulation of the waste-load allocation optimization model, with its objective being to maximize the environmental performance under constraints that existing waste discharge loads in terms of total wastewater amount, total pollutant mass, and existing PMZ size can’t be exceeded.

Conclusions
Modeling results give an optimal waste-load allocation ratio for each discharge outlet within the study section, and its implications to the reservoir water quality management were analyzed. It is anticipated that the develop approach can be extended to the entire TGR area for better water quality management studies and practices.
Review of pharmacological therapies in fibromyalgia syndrome
Authors: Häuser Winfried , Walitt Brian , Fitzcharles Mary-Ann , Sommer Claudia 
Published: January 2014

AbstractThis review addresses the current status of drug therapy for the management of fibromyalgia syndrome (FMS) and is based on interdisciplinary FMS management guidelines, meta-analyses of drug trial data, and observational studies. In the absence of a single gold-standard medication, patients are treated with a variety of drugs from different categories, often with limited evidence. Drug therapy is not mandatory for the management of FMS. Pregabalin, duloxetine, milnacipran, and amitriptyline are the current first-line prescribed agents but have had a mostly modest effect. With only a minority of patients expected to experience substantial benefit, most will discontinue therapy because of either a lack of efficacy or tolerability problems. Many drug treatments have undergone limited study and have had negative results. It is unlikely that these failed pilot trials will undergo future study. However, medications, though imperfect, will continue to be a component of treatment strategy for these patients. Both the potential for medication therapy to relieve symptoms and the potential to cause harm should be carefully considered in their administration.
Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa
Authors: McErlean Peter , Berdnikovs Sergejs , Favoreto Silvio , Shen Junqing , Biyasheva Assel , Barbeau Rebecca , Eisley Chris , Barczak Andrea , Ward Theresa , Schleimer Robert P , Erle David J , Boushey Homer A , Avila Pedro C 
Published: January 2014

Abstract
Background
Acute respiratory illness is the leading cause of asthma exacerbations yet the mechanisms underlying this association remain unclear. To address the deficiencies in our understanding of the molecular events characterizing acute respiratory illness-induced asthma exacerbations, we undertook a transcriptional profiling study of the nasal mucosa over the course of acute respiratory illness amongst individuals with a history of asthma, allergic rhinitis and no underlying respiratory disease.

Methods
Transcriptional profiling experiments were performed using the Agilent Whole Human Genome 4X44K array platform. Time point-based microarray and principal component analyses were conducted to identify and distinguish acute respiratory illness-associated transcriptional profiles over the course of our study. Gene enrichment analysis was conducted to identify biological processes over-represented within each acute respiratory illness-associated profile, and gene expression was subsequently confirmed by quantitative polymerase chain reaction.

Results
We found that acute respiratory illness is characterized by dynamic, time-specific transcriptional profiles whose magnitudes of expression are influenced by underlying respiratory disease and the mucosal repair signature evoked during acute respiratory illness. Most strikingly, we report that people with asthma who experience acute respiratory illness-induced exacerbations are characterized by a reduced but prolonged inflammatory immune response, inadequate activation of mucosal repair, and the expression of a newly described exacerbation-specific transcriptional signature.

Conclusion
Findings from our study represent a significant contribution towards clarifying the complex molecular interactions that typify acute respiratory illness-induced asthma exacerbations.
Regional variability of carbon dioxide storage potential of the Queenston Formation in New York
Authors: Tamulonis Kathryn L. , Jordan Teresa E. , Jacobi Robert D. 
Published: January 2014

Initial assessments of the potential for geologic carbon sequestration rely on existing subsurface data, most of it collected for oil and gas exploration. We document the challenges of assessing the [Formula: see text] storage potential based on archived data, for the case of the Upper Ordovician Queenston Formation in New York. In central New York, the entirely subsurface Queenston Formation consists primarily of sandstones. In contrast, in western New York where the Queenston Formation crops out, it is composed of shale, siltstone, and sandstone. A foremost interpretation challenge is to obtain porosity data from the borehole logs. Intercomparisons of various measures of porosity and of the availability of those data led to the decision to use neutron porosity data for the hematite- and clay-rich sandstone. To map porosity regionally, a second challenge is to establish the physical correlation between four regionally extensive stacked petrophysical zones in central New York, each recording base-level fall trends in fluvial sandstones, and four petrophysical zones in western New York, each characterized by base-level rise deposits of marginal marine and shallow marine deposits. Two alternative correlations can be justified with differing implications for pore volumes in a transition region. This analysis estimates that the Queenston Formation of central New York can sequester up to approximately [Formula: see text] metric tons of [Formula: see text] at depths greater than 3000 ft (914 m) in sandstones with porosity exceeding 10%. The Queenston Formation is not suitable for [Formula: see text] storage in western New York.
Working memory networks and activation patterns in schizophrenia
and bipolar disorder: comparison with healthy controls
Authors: Brandt Christine Lycke , Eichele Tom , Melle Ingrid , Sundet Kjetil , Server Andrés , Agartz Ingrid , Hugdahl Kenneth , Jensen Jimmy , Andreassen Ole A. 
Published: January 2014

BackgroundSchizophrenia and bipolar disorder are severe mental disorders with
overlapping genetic and clinical characteristics, including cognitive
impairments. An important question is whether these disorders also have
overlapping neuronal deficits.AimsTo determine whether large-scale brain networks associated with working
memory, as measured with functional magnetic resonance imaging (fMRI),
are the same in both schizophrenia and bipolar disorder, and how they
differ from those in healthy individuals.MethodPatients with schizophrenia (n = 100) and bipolar
disorder (n = 100) and a healthy control group
(n = 100) performed a 2-back working memory task
while fMRI data were acquired. The imaging data were analysed using
independent component analysis to extract large-scale networks of
task-related activations.ResultsSimilar working memory networks were activated in all groups. However, in
three out of nine networks related to the experimental task there was a
graded response difference in fMRI signal amplitudes, where patients with
schizophrenia showed greater activation than those with bipolar disorder,
who in turn showed more activation than healthy controls. Secondary
analysis of the patient groups showed that these activation patterns were
associated with history of psychosis and current elevated mood in bipolar
disorder.ConclusionsThe same brain networks were related to working memory in schizophrenia,
bipolar disorder and controls. However, some key networks showed a graded
hyperactivation in the two patient groups, in line with a continuum of
neuronal abnormalities across psychotic disorders.
Epidemic of charcoal burning suicide in Japan
Authors: Yoshioka Eiji , Hanley Sharon J. B. , Kawanishi Yasuyuki , Saijo Yasuaki 
Published: January 2014

BackgroundThe charcoal burning suicide epidemics in both Hong Kong and Taiwan have been well documented. However, little is known about the situation in Japan.AimsTo examine the impact of charcoal burning suicide on the overall and other method-specific suicide rates between 1998 and 2007 in Japan.MethodUsing data obtained from the Vital Statistics of Japan, negative binomial regression analyses were performed to investigate the impact of the charcoal burning method.ResultsIn males and females aged 15–24 and 25–44 years, the charcoal burning epidemic led to a substantial increase in overall suicides, without a decrease in other methods. In all other age groups, no such trend was observed.ConclusionsIn young Japanese, the charcoal burning method may have appealed to individuals who might not have chosen other highly or relatively lethal methods, and consequently led to an increase in overall suicides.
Central Precocious Puberty in a Girl and Early Puberty in Her Brother Caused by a Novel Mutation in the MKRN3 Gene
Authors: Settas Nikolaos , Dacou-Voutetakis Catherine , Karantza Maria , Kanaka-Gantenbein Christina , Chrousos George P. , Voutetakis Antonis 
Published: January 2014

Context:
Central precocious puberty (CPP), defined as the development of secondary sex characteristics prior to age 8 years in girls and 9 years in boys, results from the premature activation of the hypothalamic-pituitary-gonadal axis. Mutations in the imprinted gene MKRN3 have been recently implicated in familial cases of CPP.

Objective:
The objective of the study was to uncover the genetic cause of CPP in a family with two affected siblings.

Design and participants:
The entire coding region of the paternally expressed MKRN3 gene was sequenced in two siblings, a girl with CPP and her brother with early puberty, their parents, and their grandparents.

Results:
A novel heterozygous missense variant in the MKRN3 gene (p.C340G) was detected in the two affected siblings, their unaffected father, and the paternal grandmother. As expected, the mutated allele followed an imprinted mode of inheritance within the affected family. In silico analysis predicts the mutation as possibly damaging in all five software packages used. Furthermore, structural alignment of the ab initio native and mutant MKRN3 models predicts that the p.C340G mutation leads to significant structural perturbations in the 3-dimensional structure of the C3HC4 really interesting new gene motif of the protein, further emphasizing the functional implications of the novel MKRN3 alteration.

Conclusions:
We report a novel MKRN3 mutation (p.C340G) in a girl with CPP and her brother with early puberty. MKRN3 alterations should be suspected in all cases with familial CPP or early puberty, especially if male patients are also involved or the precocious puberty trend does not follow the usually observed mother-to-daughter inheritance.
Measuring individual locomotor rhythms in honey bees, paper wasps and similar sized insects
Authors: Giannoni-Guzmán Manuel A. , Avalos Arian , Marrero Jaime , Otero-Loperena Eduardo J. , Kayım Mehmet , Medina Jose A. , Massey Steve E. , Kence Meral , Kence Aykut , Giray Tugrul , Agosto-Rivera Jose L. 
Published: January 2014

Summary
Circadian rhythms in social insects are highly plastic and are modulated by multiple factors. In addition, complex behaviors such as sun-compass orientation and time learning are clearly regulated by the circadian system in these organisms. Despite these unique features of social insect clocks, the mechanisms as well as the functional and evolutionary relevance of these traits remain largely unknown. Here we show a modification of the Drosophila activity monitoring (DAM) system that allowed us to measure locomotor rhythms of the honey bee, Apis mellifera L. (three variants; gAHB, carnica and caucasica) and two paper wasp genera (Polistes crinitus and Mischocyttarus phthisicus). A side-by side comparison of the endogenous period under constant darkness (free-running period) led us to the realization that these social insects exhibit significant deviations from the 24 hour Earth's rotational period as well as a large degree of inter-individual variation compared to Drosophila. Experiments at different temperatures, using honey bees as a model, revealed that testing the endogenous rhythm at 35˚C, which is the hive's core temperature, results in average periods closer to 24h compared to 25˚C (23.8h at 35˚C vs. 22.7h at 25˚C). This finding suggests that the degree of tuning of circadian temperature compensation varies among different organisms. We expect, that the commercial availability, cost-effectiveness, and integrated nature of this monitoring system will facilitate the growth of the circadian field in these social insects and catalyze our understanding of the mechanisms as well as the functional and evolutionary relevance of circadian rhythms.
Cross generation plasticity in cold hardiness is associated with diapause, but not the non-diapause developmental pathway, in the blowfly, Calliphora vicina
Authors: Coleman Paul C. , Bale Jeffrey S. , Hayward Scott A. L. 
Published: January 2014

Summary
Predicting insect responses to global climate change involves understanding cross generation effects of temperature. The majority of temperate insects overwinter in a state of diapause, a pre-emptive response to winter conditions associated with increased cold hardiness. Diapause is often induced following maternal adult detection of an environmental cue signifying the onset of winter, whilst diapause is initiated in a subsequent life-stage/generation. Continued global warming will expose adults to higher late-autumn temperatures, whilst diapause life-stages will still experience prolonged winter-cold. The cross generation effect of temperature was investigated by acclimating adult Calliphora vicina, to present day (15°C) and future (20°C) late-autumn conditions and assessing cold-hardiness in diapause (D15 and D20) and non-diapause (ND15 and ND 20) progeny. A cross generation plasticity in cold hardiness was associated with D but not ND larvae. D15 larvae exhibited an enhanced ability to suppress the internal freezing (SCP = -18.9±0.9°C) compared to D20 (-15.3±0.8°C), and displayed a greater tolerance of prolonged exposure to -4°C (LT50 26.0± 1.0 days and 11.4±1.1 days, respectively) and -8°C (5.1±1.1 days and 3.0 ±1.1 days, respectively). These changes were associated with a reduced glucose content in D15 (2.4±0.3 g mg-1) compared to D20 (3.0±0.3 g mg-1) larvae. In conclusion, C. vicina adults exposed to warmer autumn conditions during diapause induction will produce larvae with a reduced cold hardiness capacity, which could negatively impact winter survival. Given that maternal regulation of diapause is common among temperate insects this could be a widespread phenomenon.
Heart rate as a predictor of metabolic rate in heterothermic bats
Authors: Currie Shannon E. , Körtner Gerhard , Geiser Fritz 
Published: January 2014

SummaryWhile heart rate (fH) has been used as an indicator of energy expenditure, quantitative data showing the relationship between these variables are only available for normothermic animals. To determine whether fH also predicts oxygen consumption (VO2) during torpor we simultaneously measured VO2, fH and subcutaneous body temperature (Tsub) of a hibernator, Gould's long-eared bats (Nyctophilus gouldi, 9 g, n=18), at ambient temperatures (Ta) between 0 and 25°C. At rest, fH of normothermic resting bats was negatively correlated with Ta, with maximum fH of 803 bpm (Ta=5°C). During torpor the relationship between fH and Ta was curvilinear, and at low Tsub (~6°C) fH fell to a minimum average of 8 bpm. The minimum average values for both VO2 and fH in torpor reported here were among the lowest recorded for bats. The relationship between fH and VO2 was significant for both resting (r2=0.64, p&lt;0.001) and torpid bats (r2=0.84, p&lt;0.001), with no overlap between the two states. These variables were also significantly correlated (r2=0.44, p&lt;0.001) for entire torpor bouts. Moreover, estimates of VO2 from fH did not differ significantly from measured values during the different physiological states. Our study is the first to investigate the accuracy of fH as a predictor of VO2 during torpor and indicates the reliability of this method as a potential measure of energy expenditure in the field. Nevertheless, fH should only be used to predict VO2 within the range of activities for which robust correlations have been established.
Ways to Individualize Education by means of Electronic Textbooks
Authors: Артемова  , Artemova L. 
Published: January 2014

The author presents didactic basics
for developing electronic textbook on Physics for
the 9th grade students, given that the textbook
contents should take into account cognitive traits
of students, educating on different profiles. The
role of such textbook in personalizing education
in the realm of educational practice is highlighted.
Stimulating Students to the Text-Perception Activity in the Course of Reading Foreign-Language Popular-Scientific Texts at the Stage of Pre-Profile Training
Authors: Добромыслова  , Dobromyslova Tatiana 
Published: January 2014

One of the aspects of the textual activity
– text perception - is considered, as related to
with capturing the sense and gaining information
while reading foreign popular scientific texts. The
core of the text-perception activity is explored from
the standpoint of forging certain readiness and
developing certain skills. The author reveals obstacles,
hindering perception of foreign-language
texts of this kind, presents results of teaching
materials evaluation in terms of students’ readiness
for text perception activity and outlines ways
to overcome such obstacles.
Partnership Formation: The Role of Social Status
Authors: Bhattacharya Haimanti , Dugar Subhasish 
Published: January 2014

We experimentally test for the effect of social status on the likelihood of partnership formation. We consider a two-player game where the opportunity to perform a hidden action by one player may render partnership formation difficult. In this context, we study how the assignment of partners' status to the top, middle, or bottom position of a preexisting status hierarchy affects collaboration. We find that partnership formation is remarkably sensitive to the partners' status affiliations. Collaboration is easiest when both partners share the same social status, and the probability of partnership formation decreases significantly as the status gap between the partners increases, entailing massive inefficiency. This paper was accepted by Uri Gneezy, behavioral economics.
Dynamic Pricing of Perishable Assets Under Competition
Authors: Gallego Guillermo , Hu Ming 
Published: January 2014

We study dynamic price competition in an oligopolistic market with a mix of substitutable and complementary perishable assets. Each firm has a fixed initial stock of items and competes in setting prices to sell them over a finite sales horizon. Customers sequentially arrive at the market, make a purchase choice, and then leave immediately with some likelihood of no purchase. The purchase likelihood depends on the time of purchase, product attributes, and current prices. The demand structure includes time-variant linear and multinomial logit demand models as special cases. Assuming deterministic customer arrival rates, we show that any equilibrium strategy has a simple structure, involving a finite set of shadow prices measuring capacity externalities that firms exert on each other: equilibrium prices can be solved from a one-shot price competition game under the current-time demand structure, taking into account capacity externalities through the time-invariant shadow prices. The former reflects the transient demand side at every moment, and the latter captures the aggregate supply constraints over the sales horizon. This simple structure sheds light on dynamic revenue management problems under competition, which helps capture the essence of the problems under demand uncertainty. We show that the equilibrium solutions from the deterministic game provide precommitted and contingent heuristic policies that are asymptotic equilibria for its stochastic counterpart, when demand and supply are sufficiently large. This paper was accepted by Yossi Aviv, operations management.
A Branch-and-Cut Method for Dynamic Decision Making Under Joint Chance Constraints
Authors: Zhang Minjiao , Küçükyavuz Simge , Goel Saumya 
Published: January 2014

In this paper, we consider a finite-horizon stochastic mixed-integer program involving dynamic decisions under a constraint on the overall performance or reliability of the system. We formulate this problem as a multistage (dynamic) chance-constrained program, whose deterministic equivalent is a large-scale mixed-integer program. We study the structure of the formulation and develop a branch-and-cut method for its solution. We illustrate the efficacy of the proposed model and method on a dynamic inventory control problem with stochastic demand in which a specific service level must be met over the entire planning horizon. We compare our dynamic model with a static chance-constrained model, a dynamic risk-averse optimization model, a robust optimization model, and a pseudo-dynamic approach and show that significant cost savings can be achieved at high service levels using our model. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2013.1822 . This paper was accepted by Dimitris Bertsimas, optimization.