bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of health conscious on tea consumption: A case study in Ilala Municipality-Tanzania
Authors: M Mwalilei , Hassan Maliwaza , Katikiro Robert 
Published: July 2024

Abstract

Background: In Tanzania, tea is an essential crop that contributes significantly to export revenue, employment opportunities, and income for farmers and other stakeholders, all of which are important to the nation's socioeconomic growth. The economics of Tanzania's tea sector is impacted by the industry's challenges, including low domestic consumption and a significant reliance on export markets. This study sought to investigate the impact of health-conscious tendencies on Tanzanians' tea-drinking habits.
Methods: A cross-sectional study was conducted in Ilala, one of Tanzania's most urban centres. A total of 400 respondents were conveniently included in the sample. A structured questionnaire was used to gather the data, which was then analysed using descriptive statistics to determine how participants felt about drinking tea in relation to health issues.
Results: The research found that only 20.4% of respondents drank tea for health benefits, indicating that most people were not aware of the benefits of this beverage. Conversely, the majority of the respondents believed that drinking tea was linked to health problems like high blood pressure, diabetes, and obesity, which made them prefer other drinks such as juice, soft drinks and herbal tea) over traditional tea (Camellia sinensis) due their perceived safety.
Conclusions:The findings highlight the importance of understanding consumer preferences and behaviour in developing a successful marketing plan and the challenges faced by consumers so as to promote growth in the Tanzanian tea industry.
Revolutionizing Diabetes Treatment: Computational Insights into 4- Hydroxy isoleucine Derivatives and Advanced Molecular Screening for Anti-Diabetic Compounds
Authors: Kelam Lakshmi Mounika , Gill Manjinder Singh , Sobhia M. Elizabeth 
Published: July 2024

Abstract

Background:
The present study focuses on the importance of, a peculiar nonprotein amino acid 4-hydroxy isoleucine (4OHIle) as a constituent isolated from fenugreek (Trigonella foenum-graecum), which plays a vital role in the treatment of Diabetes mellitus. Here, we represent 4-hydroxy isoleucine derivatives has the ability to simulate insulin production and increase insulin sensitivity in diabetes mellitus targets.
Objectives
In this study, using computational methods we search for suitable drug like compounds that have similar ligand binding kinetics to target diabetes mellitus.
Methods
The top drug like compounds are selected based on computational methods such as Molecular Docking, Molecular Dynamic Simulation, Gibbs Free Energy calculations and Free Energy Landscape (FEL), shape based generative modelling for de novo drug design.
Results
Docking-based simulation screened out best 2 compounds against each targeted enzyme implicated in diabetes. Further, their dynamics studies reveal that the compounds 4-OHIL, 4-OHIL-4, 2R-3S-4R-4OHIL and 4-OHIL-Amide-2 were affirmed as the best inhibitors of respective enzyme targets. The best inhibitors are further optimised using generative model (Ligdream)
Conclusion
Anticipating the competitive inhibition of target protein expression in diabetes mellitus, we envision that the best inhibitors of respective enzyme targets. The findings from this current investigation carry significant modifications for the advancement in order to improve their potential to treat type 2 diabetes
Flavone and volatile metabolite profiling of rice (Oryza sativa L.) leaf tea: a multivariate approach to identify potential bioactive compounds
Authors: Sirijan Mongkon , Hutasingh Nuti , Khaksar Gholamreza , Pewlong Putthamas , Pattarapipatkul Nattaya , Tubtimrattana Apinya , Tansrisawad Nat , Borompichaichartkul Chaleeda , Sirikantaramas Supaart 
Published: July 2024

Abstract

Seven-day-old Jasmine rice seedling leaves contain a significant amount of bioactive compounds. In this study, we examined metabolite variation and bioactive compounds in leaves subjected to freeze-drying and sun-drying processes. Using ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry and headspace gas chromatography/mass spectrometry, we identified luteolin 6-C-glucoside and chrysoeriol 6-C-glucoside as major flavones, and potential bioactive markers. The maximum extractable total hydrolyzed flavones reached approximately 4.70 ± 1.15 mg/g dry weight with hot water at 90°C for 360 s after three extractions of sun-dried tea leaves, which was significantly different from that of the ethanolic extracts (5.90 ± 0.19 mg/g dry weight). Sun-dried tea leaves exhibited a greater relative abundance of predominant volatile compounds, such as 2-methylbutanal, dodecane, 2-ethylfuran, and methylpyrazine, enhancing consumer appeal in tea infusions. We introduce jasmine rice seedling leaf tea as a health-beneficial drink that contains abundant bioactive compounds.
Tribological behavior of shaft-surface pairs with PPS and its composites in seawater media under cyclic loadings
Authors: Yuan Wei , Yao XingJu , Guo Qian , Li Can , Chi Baotao , Yu Jie 
Published: July 2024

Abstract

Shaft-surface contact friction pairs of marine equipment are often subject to the effects of wear and corrosion under cyclic loading in the seawater media. A friction and wear test bench was established to simulate the marine ship stern shaft and bearings working in seawater media. The tribological properties of pure polyphenylene sulfide (PPS), 30% glass fiber reinforced PPS (30% GF/PPS), and 30% carbon fiber reinforced PPS (30% CF/PPS) against 316L stainless steel under different lubrication conditions were investigated. The results show that the friction force and wear loss of three PPS materials against 316L stainless steel in seawater media are the smallest. Among them, carbon fiber reinforced polyphenylene sulfide has the lowest friction and wear under seawater lubrication. The friction fluctuates in the range of 5 N, and the wear is 0.028 g. Due to the inhomogeneity of glass fiber (GF) bonding with the PPS matrix, adding GF did not significantly improve PPS materials' antifriction properties and wear resistance. The wear mechanism is mainly the severe three-body abrasive wear caused by GF falling off on the surface of the friction pair. In addition, the resistance of carbon fiber to cyclic load, the mixed lubrication effect of seawater and carbon fiber debris, and the transfer effect of polymer were also discussed. The observation results show that carbon fiber can effectively resist the impact of cyclic load on the friction surface. There are synergistic anti-friction and wear-resisting effects between carbon fiber and seawater, seawater and polymer transfer film. This study will provide a reference for selecting new shaft friction pair materials under complex working conditions of seawater.
Loss of STARD7 triggers metabolic reprogramming and cell cycle arrest in breast cancer
Authors: Chariot Alain , Dondajewska Ewelina , Allepuz-Fuster Paula , Maurizy Chloé , Blomme Arnaud , Close Pierre , lavergne arnaud , Karim Latifa , Thiry Marc , Nemazanyy Ivan , Krishnankutty Roopesh , Junior Jair Marques , von Kriegsheim Alex , Henneman Nate , Panasyuk Ganna , Shostak Kateryna 
Published: July 2024

Abstract

Cancer cells adapt their metabolism to support aberrant cell proliferation. However, the functional link between metabolic reprogramming and cell cycle progression remains largely unexplored. Mitochondria rely on the transfer of multiple lipids from the endoplasmic reticulum (ER) to their membranes to be functional. Several mitochondrial-derived metabolites influence cancer cell proliferation by modulating the epigenome. Here we show that the loss of STARD7, a lipid transfer protein whose expression is enhanced in breast cancer, leads to a metabolic reprogramming characterized by the accumulation of Carnitine derivatives and S-Adenosyl-L-methionine (SAM). Elevated SAM levels causes the increase of H3K27 trimethylation on many gene promoters coding for candidates involved in cell cycle progression. Likewise, STARD7 deficiency triggers cell cycle arrest and impairs ERa-dependent cell proliferation. EGFR trafficking to lysosomes is also deregulated in breast cancer cells lacking STARD7. Therefore, mitochondria rely on STARD7 to support cell cycle progression in breast cancer.
Changes in the Transition Process of Roughness-Induced Crossflow Vortices due to Freestream Turbulence
Authors: Nakagawa Kosuke , Ishida Takahiro , Tsukahara Takahiro 
Published: July 2024

Abstract

Laminar-turbulent transitions in boundary layers are one of the major research topics in fluid dynamics.In this study, we focused on a three-dimensional boundary layer formed on a swept flat plate.In this boundary layer, the crossflow instability is dominant, and the instability induces crossflow vortices (CFVs).Many studies have focused on the dependency of the transition process on the intensities of steady or unsteady disturbances, which correspond to a roughness element and freestream turbulence (FST), respectively.On the other hand, the effects of the FST wavelength are still unclear.Moreover, there is a lack of knowledge about the transition processes caused by both steady and unsteady disturbances.We investigated how the transition process of a stationary structure caused by cylindrical roughness changes depending on the FST wavelength using direct numerical simulations.We classified transition processes into two types: processes in which stationary structures grow into CFVs and processes in which hairpin vortices are generated on the stationary structures.The former is further classified into four types depending on the presence or absence of FST and on the FST wavelength.We revealed the contributions of different FST wavelengths to the transition process changes.The short-wavelength FST provides hairpin vortices to the stationary structure at low roughness height conditions because of its high-frequency components.The long-wavelength FST changes the process due to unsteady fluctuations influencing the stationary structure.In summary, depending on the FST wavelength, the transition process is changed by a completely different mechanism.
Development and psychometric evaluation of the sexual satisfaction questionnaire for postmenopausal women (PWSSQ): an exploratory mixed method study protocol
Authors: Shahrahmani Nasim , Babazadeh Raheleh , Ebadi Abbas 
Published: July 2024

Abstract

Background
The concept of sexual satisfaction in menopausal women is very different from that in premenopausal women, and this difference is due to aging and physical, hormonal, cultural, and psychological changes. Therefore, the first step in discovering methods for assessing sexual satisfaction in postmenopausal women is to develop a measurement instrument. This study was conducted to develop and evaluate the psychometric properties of a sexual satisfaction instrument for postmenopausal women.
Methods
The current study is an exploratory-sequential mixed-methods research project that will be divided into two parts: qualitative and quantitative. Aligned with the primary objective of the research, which is to elucidate the concept of sexual satisfaction in postmenopausal women, the hybrid concept analysis model developed by Schwartz and Kim will be employed. This model comprises three key phases: the theoretical phase, the fieldwork phase, and the final analytical phase. Those who met the inclusion criteria and exhibited maximum variance in terms of age, educational level, employment status, and menopausal duration were recruited. The conventional content analysis will be carried out following the steps proposed by Graneheim and Lundman. Second, in the quantitative phase, the psychometric properties of the instrument were evaluated, including the content, face and construct validity and reliability via internal consistency and stability. The psychometric properties described in the COSMIN checklist will be utilized for designing the instrument.
Discussion
A valid and reliable scale for evaluating the sexual satisfaction of postmenopausal women should be developed, and educational content should be designed to improve the sexual satisfaction of this group of women.
On the Improvement of Schizophrenia Detection with Optical Coherence Tomography Data Using Deep Neural Networks and Aggregation Functions
Authors: Karczmarek Paweł , Plechawska-Wójcik Małgorzata , Kiersztyn Adam , Domagała Adam , Wolinska Agnieszka , Silverstein Steven M. , Jonak Kamil , Krukow Paweł 
Published: July 2024

Abstract

Schizophrenia is a serious mental disorder with a complex neurobiological background and a well-defined psychopathological picture. Despite many efforts, a definitive disease biomarker has still not been identified. One of the promising candidate for such biomarker might be the retinal morphology. In this study Optical Coherence Tomography (OCT) data is applied to assess the different layers of the retina. OCT data were applied in the process of automatic differentiation of schizophrenic patients and healthy controls. Numerical experiments covered applying several individual 1D Convolutional Neural Network based models as well as further using the aggregation of classification results to improve the initial classification results. The main goal of the study was to check how methods based on the aggregation of classification results work in classifying neuroanatomical features of schizophrenia. Among over 300, 000 different variants of tested aggregation operators, a few versions provided satisfactory results.
Comparative analysis of the musculoskeletal health of the populations of Poland and Spain: a cross-sectional study using the International Classification of Functioning, Disability and Health
Authors: Wiśniowska-Szurlej Agnieszka , Sozańska Agnieszka , Barrio Sandra Jiménez , Sozański Bernard , Laita Luis Ceballos , Lázaro Héctor Hernández 
Published: July 2024

Abstract

Background
Musculoskeletal disorders affect approximately 1.71 billion people worldwide and are a growing cause of disability. The International Classification of Functioning, Disability and Health (ICF) is the current framework for describing disability and provides a codification system that can be used to compare data across populations. The availability of comparable data would allow a better understanding of the determinants of health and improve the health of the population. The aim of the study was to make an ICF-based comparison between musculoskeletal health in Poland and Spain.
Methods
A comparative study was conducted to identify cross-cultural differences between Poland and Spain in the prevalence of ICF entities from the brief ICF core set for post-acute musculoskeletal conditions. Two datasets from previous validation studies in these populations were used for comparison. A total of 840 people with musculoskeletal conditions were included in the study. Information was recoded into ICF qualifiers to obtain comparable data. Statistical analysis included: a) calculation of absolute and relative frequencies on the prevalence of ICF entities, and b) calculation of the level of significance using the Mann-Whitney test for quantitative variables and the Chi-square test for qualitative variables.
Results
Significant differences in functioning were found between the two samples, with a higher prevalence in all the ICF entities for the Spanish sample. Similarities were found in the ICF components ‘Body Functions’ and ‘environmental factors’, with the most prevalent ICF entities being ‘b280 Sensation of pain’ (86.9% in Spain and 74.2% in Poland) and ‘e225 Climate’ (58.0% and 31.8%) respectively. For ‘Activities and Participation’, differences were observed, with ‘d430 Lifting and carrying objects’ being the most common for the Spanish sample (65.4%) and ‘d450 Walking’ for the Polish sample (47.7%).
Conclusions
A theoretical application of the ICF has been empirically tested for the first time, a milestone in the development of this research methodology. Differences in the prevalence of ICF entities showed a better musculoskeletal health in the Polish sample. Identifying the strengths and weaknesses of different health care models has the potential to improve population health by implementing best practice-based approaches.
Trial registration
NCT06283407
Sampling of Culicoides with non-traditional methods provides unusual species composition and new records for southern Spain
Authors: González Mikel Alexander , Magallanes Sergio , Bravo-Barriga Daniel , Monteys Victor Sarto i , Martinéz-Puente Josué , Figuerola Jordi 
Published: July 2024

Abstract

Background. Culicoides midges have been well-studied in Spain, particularly over the last 20 years, mainly because of their role as vectors of arboviral diseases that affect livestock. Most studies on Culicoidesare conducted using suction light traps in farmed environments, but studies employing alternative trapping techniques or focusing on natural habitats are scarce.
Methods. In the present study, we analyzed Culicoides captured in 2023 at 476 sites in western Andalusia (southern Spain) using carbon dioxide-baited BG-sentinel traps across different ecosystems.
Results. We collected 3,084 Culicoides midges (3,060 females and 24 males) belonging to 23 species, including the new species Culicoides grandifovea sp. nov. and the first record of Culicoides pseudolangeroni for Europe. Both species were described with morphological and molecular methods and detailed data on spatial distribution was also recorded. The new species showed close phylogenetic relations with sequences from an unidentified Culicoides from Morocco (92.6% similarity) and with Culicoides kurensis. Culicoides imicola was the most abundant species (17.4 %), followed by Culicoides grandifovea sp. nov. (14.6 %), and Culicoides kurensis (11.9 %). Interestingly, Culicoides montanus was the only species of the Obsoletus and Pulicaris species complexes captured, representing the first record of this species in southern Spain. A total of 53 valid Culicoides species have been reported in the area, 48 already reported in literature records and 5 more added in the present study. Information on the flight period for the most common Culicoides species is also provided.
Conclusions. To the best of our knowledge, our study represents the most comprehensive effort ever done on non-farmland habitats using carbon-dioxide baited suction traps for collecting Culicoides. Our data suggests that using carbon dioxide traps offers a completely different perspective on Culicoides communities compared to commonly used light traps, including the discovery of previously unrecorded species.
Using Linear Regression Analysis to Predict Energy Consumption
Authors: Phan Phan Dao Dao , Anh Minh Anh Nguyen Nguyen Minh , Nguyen Ba Hung HUng 
Published: July 2024

Abstract

This study explores the utilization of linear regression analysis to predict energy consumption in practical applications. The methodology involves setting up a linear regression model and applying it to real-world scenarios to demonstrate its effectiveness. Specifically, the research includes three case studies: predicting the future energy consumption of a supermarket in the UK, analyzing the energy consumption patterns of the Puerto Princesa Distribution System, and building a predictive model using data from Internet of Things (IoT) devices. The application of linear regression in these examples illustrates how accurate predictions can be achieved. Additionally, the study presents an improved energy prediction model, showcasing enhancements in predictive accuracy. The findings indicate that linear regression is a valuable tool for energy consumption forecasting, providing insights that can aid in better energy management and planning.
Drivers behind the diverging gender patterns of wage inequality
Authors: Oliver Xisco , Sard Maria 
Published: July 2024

Abstract

This paper examines wage inequality in Spain across the economic cycle of 2006–2018, focusing on gender perspectives, aiming to discern the underlying factors driving it. Employing the Firpo, Fortin, and Lemieux decomposition method, we analyse how differences in worker, firm, and job characteristics impact wage inequality evolution. Drawing on data from the Spanish Wage Structure Survey (WSS), our analysis reveals a decline in wage inequality for both genders over the entire economic cycle, with a more pronounced reduction among females. However, this decrease in wage inequality cannot be attributed to changes in worker, firm, or job characteristics of the employees (composition effects), as they actually increased. Our analysis indicates that rewards associated with these characteristics (wage structure effects) primarily drove the reduction in wage inequality. Nonetheless, gender disparities become evident when exploring the contribution of the primary explanatory variables. We find that the sector of activity is associated with lower wage inequality among females but higher among males. Conversely, the de-unionization process that occurred during the analysed period tends to increase wage inequality among males while having a neutral or opposite effect on females. A notable shift occurred during 2014–2018: while female wage inequality increased, male wage inequality continued to decline. Finally, we find no significant correlation between the economic cycle and the evolution of wage inequality.
JEL codes: J31; J71; C21 and D63.