bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardioprotective Actions of TGFβRI Inhibition Through Stimulating Autocrine/Paracrine of Survivin and Inhibiting Wnt in Cardiac Progenitors
Authors: Ho Yu-Sian , Tsai Wan-Hsuan , Lin Fen-Chiung , Huang Wei-Pang , Lin Lung-Chun , Wu Sean M. , Liu Yu-Ru , Chen Wen-Pin 
Published: September 2015

Abstract
Heart failure due to myocardial infarction (MI) is a major cause of morbidity and mortality in the world. We found previously that A83-01, a TGFβRI inhibitor, could facilitate cardiac repair in post-MI mice and induce the expansion of a Nkx2.5 + cardiomyoblast population. This study aimed to investigate the key autocrine/paracrine factors regulated by A83-01 in the injured heart and the mechanism of cardioprotection by this molecule. Using a previously described transgenic Nkx2.5 enhancer-green fluorescent protein (GFP) reporter mice, we isolated cardiac progenitor cells (CPC) including Nkx2.5-GFP + (Nkx2.5+), sca1+, and Nkx2.5+/sca1 + cells. A83-01 was found to induce proliferation of these three subpopulations mainly through increasing Birc5 expression in the MEK/ERK-dependent pathway. Survivin, encoded by Birc5, could also directly proliferate Nkx2.5 + cells and enhance cultured cardiomyocytes viability. A83-01 could also reverse the downregulation of Birc5 in postinjured mice hearts (n = 6) to expand CPCs. Moreover, the increased Wnt3a in postinjured hearts could decrease CPCs, which could be reversed by A83-01 via inhibiting Fzd6 and Wnt1-induced signaling protein 1 expressions in CPCs. Next, we used inducible αMHC-cre/mTmG mice to label cardiomyocytes with GFP and nonmyocytes with RFP. We found A83-01 preserved more GFP + myocytes (68.6% ± 3.1% vs. 80.9% ± 3.0%; p &lt; .05, n = 6) and fewer renewed RFP + myocytes (0.026% ± 0.005% vs. 0.062% ± 0.008%; p &lt; .05, n = 6) in parallel with less cardiac fibrosis in isoprenaline-injected mice treated with A83-01. TGFβRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt in CPCs to mediate cardioprotection and improve cardiac function.
LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway
Authors: Zhou Mingli , Hou Yixuan , Yang Guanglun , Zhang Hailong , Tu Gang , Du Yan-e , Wen Siyang , Xu Liyun , Tang Xi , Tang Shifu , Yang Li , Cui Xiaojiang , Liu Manran 
Published: September 2015

Summary
Cancer stem cells (CSCs) are a subpopulation of neoplastic cells with self-renewal capacity and limitless proliferative potential as well as high invasion and migration capacity. These cells are commonly associated with epithelial-mesenchymal transition (EMT), which is also critical for tumor metastasis. Recent studies illustrate a direct link between EMT and stemness of cancer cells. Long non-coding RNAs (lncRNAs) have emerged as important new players in the regulation of multiple cellular processes in various diseases. To date, the role of lncRNAs in EMT-associated CSC stemness acquisition and maintenance remains unclear. In this study, we discovered that a set of lncRNAs were dysregulated in Twist-positive mammosphere cells using lncRNA microarray analysis. Multiple lncRNAs-associated canonical signaling pathways were identified via bioinformatics analysis. Especially, the Shh-GLI1 pathway associated lncRNA-Hh, transcriptionally regulated by Twist, directly targets GAS1 to stimulate the activation of hedgehog signaling (Hh). The activated Hh increases GLI1 expression, and enhances the expression of SOX2 and OCT4 to play a regulatory role in CSC maintenance. Thus, the mammosphere-formation efficiency (MFE) and the self-renewal capacity in vitro, and oncogenicity in vivo in Twist-positive breast cancer cells are elevated. lncRNA-Hh silence in Twist-positive breast cells attenuates the activated Shh-GLI1 signaling and decreases the CSC-associated SOX and OCT4 levels, thus reduces the MFE and tumorigenesis of transplanted tumor. Our results reveal that lncRNAs function as an important regulator endowing Twist-induced EMT cells to gain the CSC-like stemness properties.
Adolescents' emotional engagement in friends' problems and joys: Associations of empathetic distress and empathetic joy with friendship quality, depression, and anxiety
Authors: Smith Rhiannon L. 
Published: September 2015

ABSTRACTAlthough empathetic distress (i.e., taking on a friend's emotional distress as one's own) has been examined as a “cost of caring” especially common among girls, relations with adjustment remain untested. The current study tested associations of empathetic distress with friendship quality, depression, and anxiety. Adolescents (N = 300, ages 12–18) reported on their perceived experience of empathetic distress following a conversation with a friend about problems. The study also considered youths' emotional engagement in friends' positive life events, referred to as empathetic joy. Results indicated that girls reported greater empathetic distress and empathetic joy compared with boys. Findings also suggest that although empathetic distress may have positive implications for youths' friendship adjustment, this may come at the expense of emotional well‐being. In contrast, empathetic joy was associated with greater positive friendship quality and fewer internalizing symptoms.
Identity statuses and psychosocial functioning in Turkish youth: A person‐centered approach
Authors: Morsunbul Umit , Crocetti Elisabetta , Cok Figen , Meeus Wim 
Published: September 2015

ABSTRACTIn the present study, we tested whether the five identity statuses of the original Meeus–Crocetti model could be extracted in a Turkish sample. Their three‐factor model of identity was used to examine identity formation. Participants were 1201 (59.6% females) youth aged between 12 and 24 years (Mage = 17.53 years, SDage = 3.25). Findings revealed that the five identity statuses extracted in previous studies (Crocetti, Rubini, Luyckx, & Meeus, 2008; Crocetti, Schwartz, Fermani, Klimstra, & Meeus, 2012) also emerged in a sample of Turkish adolescents and emerging adults. Findings indicated that gender and age affected the distribution of the individuals among the five identity statuses. Furthermore, individuals in the five identity statuses represented distinct profiles according to personality and self characteristics, problem behaviors and well‐being, and interpersonal and group relationships. Finally, the status × age interactions indicated that the searching moratorium status became more problematic with age. Implications and suggestions for future research are also discussed.
Sterile Processing Accreditation Surveys: Risk Reduction and Process Improvement
Authors: Seavey Rose E. 
Published: September 2015

AbstractAccreditation surveys protect patients and personnel by monitoring health care facility compliance with rules, regulations, and best practices. Accreditation, or the lack of it, can affect a facility's ability to be reimbursed. The ability of personnel to follow best practices and adhere to regulatory requirements in the surgical processing department and the OR has a critical effect on reducing or eliminating health care‐associated infections, including surgical site infections. This article discusses preparing for an accreditation survey, being ready to demonstrate compliance when surveyed, and how accreditation surveys help reduce risk for patients and personnel, promote best practices, and improve patient care.
Transfer‐of‐Care Communication: Nursing Best Practices
Authors: Chard Robin , Makary Martin A. 
Published: September 2015

AbstractThe successful and safe transfer of the patient from one phase of care to another is contingent on optimal communication by all team members. Nurses are often in a natural leadership position to improve safe practices during hand overs. A holistic understanding of the patient allows the perioperative nurse the opportunity to identify issues and choose a nursing diagnosis based on key elements of a patient's needs and goals—information that should be relayed during patient transfers. This article reviews best practices in transfer‐of‐care communication to enable perioperative RNs to take an active, leading role in hand‐over processes.
Interpreting Arterial Blood Gases Successfully
Authors: Larkin Brenda G. , Zimmanck Robert J. 
Published: September 2015

AbstractArterial blood gas (ABG) analysis is a crucial skill for perioperative nurses, in particular the RN circulator. This article provides the physiological basis for assessing ABGs perioperatively and presents a systematic approach to blood gas analysis using the Romanski method. Blood gas sample data allow the reader to practice ABG interpretation. In addition, four case studies are presented that give the reader the opportunity to analyze ABGs within the context of surgical patient scenarios. The ability to accurately assess ABGs allows the perioperative nurse to assist surgical team members in restoring a patient's acid‐base balance.
Creating a Culture of Safety by Reducing Noise Levels in the OR
Authors: Hogan Lisa J. , Harvey Renee L. 
Published: September 2015

AbstractWe implemented a quality improvement project to reduce noise levels in the OR in response to complaints from the anesthesia staff members at two community hospitals. Excessive noise has been shown to increase staff member stress, fatigue, distraction, and ineffective communication, which can lead to medical errors. We measured noise levels during anesthesia induction and emergence for 118 different surgical procedures and compared noise levels before and after the improvement project intervention. Staff member education and noise reduction strategies, which included signage, prominent noise meters, and specific suggestions to staff members, helped to significantly reduce the noise level during the anesthetic induction and emergence phases of OR procedures.
STOP: Can We Minimize OR Traffic?
Authors: Elliott Sara , Parker Stacy , Mills Judi , Meeusen Lindsay , Frana Theresa , Anderson Marie , Storsveen Amy , White Amy 
Published: September 2015

AbstractPerioperative nurses at our institution voiced concerns about the amount of traffic in the ORs. We formed a workgroup consisting of perioperative nurses, educators, and leaders and initiated a quality improvement (QI) project to identify the amount of OR traffic that occurs during a procedure. The workgroup developed a check sheet to record door swings, staff classifications, reasons for opening the door, and the number of people in the OR at 15‐minute intervals. Baseline results showed that average door swings ranged from 33 per hour in general surgery to 54 per hour in cardiac surgery. Nurses accounted for the most traffic, citing retrieving supplies as the main reason. Interventions focused on decreasing nurse traffic for retrieval of supplies in general surgery. Follow‐up observations showed that average door swings increased to 41 per hour in general surgery, but nurse traffic decreased. Monitoring and limiting traffic could positively affect patient safety and outcomes.
Maternal and neonatal outcomes in multiple pregnancy: A multicentre study in the Beijing population
Authors: Su Ri‐Na , Zhu Wei‐Wei , Wei Yu‐Mei , Wang Chen , Feng Hui , Lin Li , Yang Hui‐Xia 
Published: September 2015

AbstractObjectiveTo compare the adverse maternal and neonatal outcomes of multiple pregnancy and singleton pregnancy from multiple medical centers in Beijing.MethodsData concerning maternal and neonatal adverse outcomes in multiple and singleton pregnancies were collected from 15 hospitals in Beijing by a systemic cluster sampling survey conducted from 20 June to 30 November 2013. The SPSS software (version 20.0) was used for data analysis. The χ2 test was used for statistical analyses.ResultsThe rate of caesarean deliveries was much higher in women with multiple pregnancies (85.8%) than that in women with singleton pregnancies (42.6%, χ2 = 190.8, P < 0.001). The incidences of anemia (χ2 = 40.023, P < 0.001), preterm labor (χ2 = 1021.172, P < 0.001), gestational diabetes mellitus (χ2 = 9.311, P < 0.01), hypertensive disorders (χ2 = 122.708, P < 0.001) and post‐partum hemorrhage (χ2 = 48.550, P < 0.001) was significantly increased with multiple pregnancy. In addition, multiple pregnancy was associated with a significantly higher rate of small‐for‐gestational‐age infants (χ2 = 92.602, P < 0.001), low birth weight (χ2 = 1141.713, P < 0.001), and neonatal intensive care unit (NICU) admission (χ2 = 340.129, P < 0.001).ConclusionsMultiple pregnancy is a significant risk factor for adverse maternal and neonatal outcomes in Beijing. Improving obstetric care for multiple pregnancy, particularly in reducing preterm labor, is required to reduce the risk to mothers and infants.
Rivaroxaban in preventing venous thromboembolism after arthroplastic surgery in Taiwan
Authors: Mao Yun‐Chuan , Chen Shih‐Tse , Chen Chung‐Hwan , Hsieh Kun‐Pin , Gan Kim‐Hong 
Published: September 2015

AbstractVenous thromboembolism (VTE) is one of the severe complications of total hip arthroplasty (THA) and total knee arthroplasty (TKA). The incidence of VTE could be reduced if preventive antithrombotic medicines are used; however, the incidence of bleeding may increase. Rivaroxaban is a factor Xa inhibitor that prevents VTE after THA or TKA. This study is designed to confirm the efficacy and safety of rivaroxaban in Taiwan. This is a retrospective database study based on the data of 6996 patients provided by the Taiwan National Health Insurance Research Database from 2008 to 2012. The data included the number of prescription, the cost of prescription, and case number for patients treated with antithrombotic agents for the prevention or treatment of joint arthroplasty complications (including THA, TKA, partial hip arthroplasty, revision THA and TKA), and the incidence of thrombosis and hemorrhage from year 2008 to 2012. The overall postoperative VTE rate was 0.49%. Compared with other antithrombotic drugs, rivaroxaban and heparin analogs can reduce the percentage of thrombosis. We also found that the expenditure and hospitalization was less in the rivaroxaban group than in the heparin analogs group. Because some benefits of rivaroxaban were found in our study, further cost‐effective and drug safety studies are warranted. It is important to consider the cost‐effective principle for the use of antithrombotic drugs in preventing thromboembolic complications after total joint arthroplasty.
Standard percutaneous nephrolithotomy alone versus in combination with intraoperative anterograde flexible nephroscopy for staghorn stones: A retrospective study
Authors: Goktug Goksel , Karakoyunlu Nihat , Sener Nevzat Can , Zengin Kursad , Nalbant Ismail , Karabacak Osman , Ozturk Ufuk , Imamoglu Abdurrahim 
Published: September 2015

AbstractThis study aimed to compare the outcomes of standard percutaneous nephrolithotomy (PCNL) to PCNL with intraoperative antegrade flexible nephroscopy (IAFN) for treating stones of staghorn nature. We retrospectively analyzed patients treated using PCNL between January 2007 and July 2013. A total of 1250 patients were treated using PCNL, and 166 patients had staghorn stones. All patients had been subjected to a complete blood count, routine biochemical analyses, coagulation tests, a complete urine analysis, and urine cultures. Patients with a positive urine culture had been treated with appropriate antibiotics until the urine culture became negative. After purchasing a flexible renoscope in March 2012, we routinely used this tool to improve the stone‐free (SF) rate. The 105 patients who underwent standard PCNL prior to March 2012 were classified as Group 1, and the 61 patients who underwent PCNL + IAFN after that date were classified as Group 2. The two groups had similar and homogeneous demographic data. The fluoroscopy and total operative times were significantly higher in Group 2 than in Group 1 (p < 0.01). Additionally, the hospitalization time (p < 0.01) and the mean hematocrit decrease (p < 0.01) were significantly lower in Group 1. In both groups, the SF rates were higher than 85%, similar to those reported in the literature. Although Group 2 had a slightly better SF rates, this difference was not statistically significant. For staghorn calculi, PCNL combined with IAFN yields excellent outcomes. However, similar prospective studies on larger cohorts should be performed to support our findings.
The Pogromnoe deposit as an unconventional commercial type of gold mineralization in Transbaikalia
Authors: Spiridonov A.M. , Zorina L.D. , Kulikova Z.I. , Budyak A.E. , Parshin A.V. , Granina E.M. , Pavlova L.A. 
Published: September 2015

Abstract
We studied the mineralogic and geochemical features of metasomatic rocks and ores from the Pogromnoe gold deposit, which is unconventional for Transbaikalia. The deposit, which formed in the Early Cretaceous, at the rifting stage of the regional evolution, is localized in the dynamoclastic strata of the Mongol–Okhotsk suture, along which the Siberian continent joined the Mongolia–China continent in the Early–Middle Jurassic. Gold mineralization occurs as two morphologic types of ores: stockwork quartz–carbonate–arsenopyrite–pyrite ores in altered volcanics (orebody no. 1) and veinlet–vein quartz ones (with disseminated sulfides) in altered carbonaceous shales (orebody no. 10). The host rocks of the deposit are the highly altered volcanosedimentary rocks of the Butorovskii Formation (Shadoron Group, J2-3), which transformed into metasomatic (by composition) and dynamoclastic (by texture and structure) rocks. It has been found that the formation of the metasomatic rocks and mineralization proceeded in several stages. Propylites formed at the preore stage (J3); tectonic schists and albitophyres, at the late preore stage; and sericitolites and albite–carbonate–sericite–quartz metasomatic rocks (quartzites), at the synore stage. The 40Ar/39Ar age of the stockwork system of ore-bearing fractures and metasomatic rocks which formed at the late preore stage is estimated as 139.5 ± 1.8 Ma. The gold-bearing rocks at the deposit are the late preore and synore metasomatic rocks formed after volcanics with sulfide mineralization (gold concentrators are pyrite II and III and arsenopyrite I and II) and after altered carbonaceous shales (gold concentrators are vein quartz and arsenopyrite II). Gold grade is completely consistent with silicification, saturation with quartz–sulfide and sulfide microveinlets, and fine sulfide dissemination. By genesis, the Pogromnoe deposit belongs to objects which formed in shear zones with the contribution of gold-bearing mantle fluids. The authors presume that the sources of mineralization are the ore-producing granitoids of the Amudzhikan–Sretensk intrusive assemblage within the Aprelkovo ore–magmatic system (OMS) (Os’kina and Urguchan plutons). This is confirmed by Pb isotope compositions (207Pb/204Pb and 206Pb/204Pb) for the pyrite and arsenopyrite of the Pogromnoe gold-bearing ores, which testify to the widespread occurrence of “mantle” Pb isotope signatures. The 40Ar/39Ar age of the ore-producing granitoids of the Aprelkovo OMS is 131.0 ± 1.2 Ma. Gold in the orebodies occurs in native form and is fine and very fine. By gold grade, the Pogromnoe deposit deserves very close attention as a new commercial type of gold mineralization in Transbaikalia.
Typomorphism of pyrite of the Sukhoi Log deposit (East Siberia)
Authors: Tauson V.L. , Akimov V.V. , Lipko S.V. , Spiridonov A.M. , Budyak A.E. , Belozerova O.Yu. , Smagunov N.V. 
Published: September 2015

Abstract
The typomorphic features of pyrite of the Sukhoi Log deposit were studied by a set of volumetric and surface methods: electron probe microanalysis, scanning electron and probe microscopy, powder X-ray diffraction, X-ray photoelectron and Auger electron spectroscopy, atomic-absorption spectrometry in the SSADSC (method of statistical sample of analytical data for single crystals) version, and atomic-emission spectrometry. Pyrite from the Sukhoi Log deposit has the following distinctive features: permanent presence of sulfite ion, which often dominates over other surface sulfur anions; weakly determined size dependence of the content of uniformly distributed Au owing to the presence of an internal concentrator of gold—dispersed carbonaceous material—in pyrite from ore zones; cell sculptures of the crystal faces, which appeared owing to the nanofragmentation of the growth surface; micro- and nanoinclusions of carbonaceous phases within crystals, associated with defects in their structure; and thin films enriched in O and C on the surface of and within the crystals. It has been shown that gold–sulfide mineralization at the Sukhoi Log deposit formed in a single ore-generating hydrothermal system, in which gold, sulfur, and carbon belonged to a microparagenesis. Some features (composition of surface, characteristics of submicroscopic structure, and elemental composition) evidence that the conditions of crystallization of pyrite in inter-ore space were different from the conditions of its genesis in the ore zones, which suggests the presence of at least two genetic types of pyrite. Carbonaceous micro- and nanoparticles and O- and C-containing films can favor an increase in the adsorption of gold from cyanide solutions on pyrite. To reduce this effect during gold recovery, a technique for surface modification should be elaborated. The ways for solving the most complicated problems dealt with the source of noble metals (NM) and the ore specialization of the deposit have been outlined. For this purpose, a detailed analysis of the main ore minerals for trace-element speciation is required. In the case of the magmatic source of NM, correlation between the contents of Au and PGE structural forms should exist. On the other hand, there is no correlation between the structural forms of Au or Pt and elements whose contents in fluid are determined by the host rock rather than the magmatic source.