bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immature dendritic cell-targeting mRNA vaccine expressing PfCSP enhances protective immune responses against Plasmodium liver infection
Authors: Sriniva Prakash , Yanik Sean , Venkatesh Varsha , Gordy James , Alameh Mohamad-Gabriel , Meza Jacob , Li Yangchen , Glass Elizabeth , Flores-Garcia Yevel , Tam Ying , Chaiyawong Nattawat , Sarkar Deepti , Weissman Drew , Markham Richard 
Published: July 2024

Abstract

Resurgence in malaria has been noted in 2022 with 249 million clinical cases resulting in 608,000 deaths, mostly in children under five. Two vaccines, RTS, S, and more recently R21, targeting the circumsporozoite protein (CSP) are recommended by the WHO but are not yet widely available. Strong humoral responses to neutralize sporozoites before they can infect the hepatocytes are important for vaccine-mediated protection. Suboptimal protection conferred by these first-generation vaccines highlight the need for approaches to improve vaccine-induced immune responses. With the recent success of mRNA-LNP vaccines against COVID-19, there is growing interest in leveraging this approach to enhance malaria vaccines. Here, we present the development of a novel chemokine fusion mRNA vaccine aimed at boosting immune responses to PfCSP by targeting the immunogen to immature dendritic cells (iDC). Vaccination of mice with mRNA encoding full-length CSP fused to macrophage inflammatory protein 3 alpha (MIP3α) encapsulated within lipid nanoparticles (LNP) elicited robust CD4 + T cell responses and enhanced antibody titers against NANP repeat epitopes compared to a conventional CSP mRNA-LNP vaccine. Importantly, the CSP-MIP3α fusion vaccine provided significantly greater protection against liver infection upon challenge with P. berghei PfCSP transgenic sporozoites. This enhanced protection was associated with multifunctional CD4 + T cells levels and anti-NANP repeat titers. This study highlights the potential to augment immune responses to PfCSP through iDC targeting and bolster protection against malaria liver infection.
Increased Catalytic Activity of the Sabatier Reaction for Space Applications
Authors: Higashi Shougo , Maegawa Yoshifumi , Goto Yasutomo , Miwa Kazutoshi , Yokoi Masahiro , Takahashi Naoko , Kosaka Satoru , Urushihara Daisuke , Asaka Toru , Teschner Detre , Vélez Juan , Cruz Daniel , Blume Raoul , Schloegl Robert , Cuenya Beatriz Roldan , Knop-Gericke Axel 
Published: July 2024

Abstract

Water is crucial in space missions, and developing lightweight, high-performing catalysts for water recycling is essential. Extensive research on nanosized and even single-atom catalysts supported on oxides has been conducted for this purpose. However, the oxide supports usually constitute over 90% of the total mass, so the catalysts are heavy. Here, we fabricated a light, fibrous RuO2 nanostructured textile consisting solely of RuO2 nanoparticles (NPs), which did not require an oxide support, and evaluated it in the Sabatier reaction for water recycling. Remarkably, this support-free catalyst textile displayed an unprecedented catalytic mass activity (~60 mmolCH4 h-1 gcat-1 at 160 °C), which was approximately 20 times higher than that of a previously reported Ru/TiO2 catalyst, and the highest TOF (0.021 s-1 at 160 °C). Although well-known catalyst degradation was observed during prolonged testing, the performance of the textile remained exceptional even after 46 hours of continuous operation. A detailed surface analysis unveiled phenomena such as RuO2 reduction, nanoparticle growth, surface smoothing, and Ru loss during the reaction, contributing to degradation. We expect that addressing these intrinsic and thermodynamically driven phenomena will improve activity and durability.
Phyllosphere microbiome assembly in wild green foxtail: designing synthetic communities for domesticated millet protection
Authors: Zai Xiaoyu , Zhu Feng , Zhao Meicheng , Diao Xianmin , Zhang Fusuo , Dini-Andreote Francisco , Melkonian Chrats , Medema Marnix H. , Raaijmakers Jos M. , Cordovez Viviane , Song Chunxu 
Published: July 2024

Abstract

Designing effective synthetic microbial communities (SynComs) allows for reconstitution of specific microbiome-associated plant phenotypes, including enhanced growth and tolerance to (a)biotic stresses. In particular, understanding the interplay of mechanisms dynamically structuring the microbiota assembly and functioning of wild crop ancestors has been proposed as a novel strategy to ‘rewild’ crop microbiomes for enhanced growth and health. Here, we profiled the phyllosphere microbiota of wild green foxtail millet plants collected from seven geographically diverse natural ecosystems and showed that variations in soil parameters and climatic conditions as well as plant genetic distance significantly correlated with bacterial and fungal community compositions. Environmental selection was found to strongly govern the assembly of bacterial communities with narrow habitat niche breadth, while dispersal limitation was predominant in structuring the assembly of fungal communities displaying broader substrate utilization. Specific bacterial and yeast genera were identified as core phyllosphere taxa based on their abundance and prevalence across the seven sampling sites. Moreover, several bacterial (Bacillus, Pantoea, Methylobacterium) and yeast genera (Vishniacozyma, Filobasidium, Sporobolomyces) displayed significant correlations with the abundances of one or more foliar pathogenic fungi, in particular Alternaria. Subsequent isolation and identification of these bacterial and yeast genera allowed the design of SynComs that protected the domesticated foxtail millet from leaf infections by Alternaria alternata. These results show that fundamental knowledge of the phyllosphere microbiota of a wild crop ancestor across large geographic scales can be leveraged to design cross-kingdom SynComs with beneficial traits for the health of their domesticated crop counterparts.
Assessment of Radiological Impacts for Individuals Associated with Natural Occurring Radioactive Materials in Ceramic Industry
Authors: Taha T M 
Published: July 2024

Abstract

There is a trend in public worldwide to use ceramic tiles in domestic decoration , monitoring the radiation risk for individuals due to used ceramic materials is needed. The current study aims at assessing the radiological impact to individuals associated with natural radioactivity levels in ceramic materials. The specific activity of natural radionuclides was measured in the investigated ceramic materials using high purity germanium detector gamma spectrometry (HPGe) with 25% coaxial efficiency. The raw materials of the ceramic are made of a mixture of bicarbonate perc, clay, feldspar, glass sand, limestone, talc, kaolin minerals, and zalouky and zirconium silicates. The Radium equivalent activity, annual effective dose, and external hazard indexes (Hex) and excess cancer life risk (ECLR) were assessed using standard protocols. The present results indicated that the annual effective dose resulting from 226Ra, 232Th, 40K is within dose constrains and lower than the public dose limit recommended by ICRP.
Infantile Colic in Karachi: Exploring Maternal Awareness, Attitude and Management Approaches
Authors: Ali Syed Rohan , Raqib Moosa Abdur , Mehtab Kiran , Nafees Munir , TAFHEEM MALIK HAMDAN 
Published: July 2024

Abstract

Objective:
This study aimed to provide updated insights into the epidemiology of infantile colic in Karachi, contributing to targeted healthcare interventions and policies aimed at alleviating colic-related distress among infants and their families in urban settings
Public policies on human rights to water in informal settlements: a bibliometric analysis
Authors: Rodrigues Paulo Marco , Gonçalves Jorge , Marques Rui Cunha 
Published: July 2024

ABSTRACT
Global attention and academic research have focused on the intersection of informal settlements, water rights, and public policy implementation. However, the overlap of these topics remains underexplored, and trends are largely unknown. This study aims to identify aspects related to public policies on human rights to water in informal urban settlements (IUS) and their association with the United Nations Sustainable Development Goals (SDGs). A bibliometric analysis of 1,702 publications from 1978 to June 2023 was conducted using R Studio and Biblioshiny. Descriptive analysis, clustering, and mapping were employed to identify key measures for effective public policies. These include infrastructure investment, fair water pricing regulation, and socioeconomic inclusion. Furthermore, it was found that public policies should be adaptive and inclusive, with a focus on gender-sensitive approaches to address unique challenges faced by women. It is recommended that these policies prioritize environmental sustainability and innovative technologies, to support the SDGs 6, 10, 11, and 13. This will enhance resilience and well-being in IUS communities.
Impact of feeding regimes on the performance of anaerobic sequencing batch membrane bioreactor treating wastewater from an urban drain
Authors: Tomar Sachin Kumar , Deshpande Aditi , Dhiman Sourbh , Singh Ravi Karan , Balakrishnan Malini 
Published: July 2024

ABSTRACT

This work evaluated an anaerobic sequencing batch membrane bioreactor (AnSBR-MBR) equipped with waste-based ceramic membranes for treating low-strength real drain wastewater. Two feeding regimes, viz. settled feed (Phase 1) and mixed feed (Phase 2) were compared. The biological performance (chemical oxygen demand (COD) and phosphate (PO43-) removal) and filtration performance (total suspended solids (TSS) removal and membrane fouling) were investigated. The reactor characteristics in terms of solids content, sludge settling behaviour, and extracellular polymeric substances (EPS) were also assessed. In Phase 1, the settled feed (with the absence of particulate organic matter) resulted in low volatile suspended solids (VSS; 0.23 ± 0.15 g/L), causing low COD removal (28.38 ± 8.14%). In the mixed feed regime in Phase 2, VSS increased (1.82 ± 0.60 g/L) due to the organic content in the particulate matter, which gave microorganisms additional food, resulting in increased COD removal (47.42 ± 2.81%); this phase was also characterised by lower membrane fouling because of the lower EPS content. Marginally higher TSS removal was obtained as well in Phase 2 (96.72 ± 3.26%) than in Phase 1 (90.48 ± 8.14%). This work demonstrates that AnSBR-MBR performance is superior with mixed drain wastewater containing suspended solids and thus pre-settling is not recommended.
ACE I/D and A2350G Polymorphisms are Correlated with Body Mass Index, but Not with Body Weight and Essential Hypertension: Study in Javanese Postmenopausal Women
Authors: Utami Sri Lestari , Simamora Dorta , Idawati Ira , Widjaja Jimmy Hadi 
Published: July 2024

Background: Genetics was one of the risk factors for essential hypertension (EH). Research on ACE I/D and A2350G polymorphisms associated with risk factors for hypertension in Indonesia has never been done. Therefore, this study was conducted to analyze the relationship between the genotype and alleles of this gene with EH, body weight, and body mass index (BMI) in Javanese postmenopausal women.Materials and methods: This cross-sectional study involved 69 postmenopausal Javanese women according to several criteria related with hypertension risk factors. The data were obtained from the measurement and questionnaire results, along with Towards Health Card Records. The polymerase chain reaction (PCR) genotyping method used was the restriction fragment length polymorphism and allele-specific.Results: The prevalence of hypertension, prehypertension, and normotension in Javanese postmenopausal women were 0.246, 0.13, and 0.623, respectively. The frequency of BMI classification as underweight, normal, overweight, or obese were 0.029, 0.42, 0.261, and 0.29, respectively. The ACE I/D and A2350G polymorphism variant genotypes and frequencies found were II (0.464), ID (0.522), DD (0.014), and AA (1). Meanwhile, the alleles and their frequencies at ACE I/D gene polymorphism were I (0.725) and D (0.275). The II and ID genotype was mostly found in normotension subjects. The DD genotype was only available in hypertension subjects. There was no association between genotypes and alleles of ACE I/D, hypertension, body weight, and BMI classification (p>0.05). There was an association between these genotypes, alleles, and BMI (p<0.05).Conclusion: ACE I/D polymorphism is susceptible for BMI in Javanese postmenopausal women.Keywords: Javanese postmenopausal, essential hypertension, ACE I/D, ACE A2350G
Two management cases of intrauterine device translocation to the bladder
Authors: Nechiporenko A. N. 
Published: July 2024

Introduction Intrauterine devices (IUDs) are widely used worldwide. One of the rare but serious complications is uterine perforation and the penetration of an IUD through the uterine wall into the bladder. In this report, we present two cases of IUD removal from the bladder wall.Clinical case. Two patients were referred for recurrent episodes of dysuria. Medical imaging and cystoscopy revealed a foreign body in the bladder wall, which was confirmed to be an IUD that had been inserted into the uterine cavity several years prior and partially migrated into the bladder lumen. Both patients underwent successful transurethral surgery, with complete removal of the IUD without fragmentation.Discussion. The removal of the IUD through the bladder did not cause any complications, and the patients were discharged from the hospital after five days. The translation of the IUD is possible if there is partial or complete damage to the wall of the cervix, isthmus or uteral body during the installation of the device.Conclusion. Patients with an IUD in place and frequent episodes of acute cystitis should have a cystoscopy to rule out bladder perforation caused by the IUD. The removal of the IUD through the urethra using an cystoscope and forceps is a relatively simple procedure that does not usually cause any intraoperative, immediate or delayed postoperative complications.
Patient and Provider Satisfaction With a Geomapping Tool for Finding Community Family Physicians in Ontario, Canada: Cross-Sectional Online Survey Study
Authors: Belanger Christopher , Peixoto Cayden , Francoeur Sara , Bjerre Lise M 
Published: July 2024

Background
Language-concordant health care, or health care in a patient’s language of choice, is an important element of health accessibility that improves patient safety and comfort and facilitates an increased quality of care. However, prior research has found that linguistic minorities often face higher travel burdens to access language-concordant care compared to the general population.

Objective
This study intended to assess patient experiences and satisfaction with an online interactive physician map that allows patients to find family physicians who speak their preferred language in and around Ottawa, Ontario, Canada, as a means of identifying areas of improvement.

Methods
This study used an online survey with questions related to user satisfaction. Responses to Likert-scale questions were compiled as summary statistics and short-answer responses underwent thematic analysis. The study setting was Ottawa and Renfrew County, Ontario, and the surrounding region, including the province of Quebec.

Results
A total of 93 respondents completed the survey and self-identified as living in Ontario or Quebec. Overall, 57 (61%) respondents were “very satisfied” or “somewhat satisfied” with the map, 16 (17%) were “neither satisfied nor dissatisfied,” and 20 (22%) were “very dissatisfied” or “somewhat dissatisfied.” We found no significant differences in satisfaction by preferred language, age group, physician attachment, or intended beneficiary. A total of 56 respondents provided short-answer responses to an open-ended question about map improvements. The most common specific suggestion was to show which physicians are accepting new patients (n=20). Other suggestions included data refreshes (n=6), user interface adjustments (n=23), and additional languages (n=2). Some participants also provided positive feedback (n=5) or expressed concern with their inability to find a family physician (n=5). Several comments included multiple suggestions.

Conclusions
While most patients were satisfied with the online map, a significant minority expressed dissatisfaction that the map did not show which family physicians were accepting new patients. This suggests that there may be public interest in an accessible database of which family physicians in Ontario are currently accepting new patients.
Pengelompokan Kata Berdasarkan Kemiripan Ucapan Pada Kamus Menggunakan Algoritma Metaphone Pada Sistem Operasi Android
Authors: Maryanto Aditya Dwi , Munarko Yuda , Azhar Yufis 
Published: July 2024

Indonesia is an archipelagic country consisting of various tribes and cultures and different languages. One of them is the Sumbawa language used by the people of the western part of the island of Sumbawa. Sumbawa language has 4 dialects namely Samawa, Taliwang, Jereweh, and Tongo. In Sumbawa there are also homophonic, homonim, and homograph words. Grouping words based on the similarity of speech to the Sumbawa dictionary used Metaphone algorithm on the android operating system is discussed in this study. Metaphone algorithms can be applied to multiple languages with rules that have been modified according to the desired language characteristic. Based on the results of testing the recall and precision on the new rules Metaphone algorithm can be concluded that the grouping of words based on similarity of speech in Sumbawa language can be said to be effective. The average percentage index of the recall test is 98,97% and the precision is 78,52%.
Steganografi Dalam File Citra Menggunakan Fungsi Hash dan Metode MLSB
Authors: Yuniarto Alfian , Cahyono Eko Budi , Minarno Agus Eko 
Published: July 2024

Semakin berkembangnya jaringan internet dapat mempermudah proses pertukaran informasi. Ketika suatu informasi bersifat rahasia ditransmisikan lewat jaringan komputer/internet, maka diperlukan jaminan bahwa informasi tersebut hanya dapat diakses oleh pihak yang berkepentingan. Pernaslahan tersebut dapat di selesaikan dengan salah satu cara yaitu penyembunyian pesan dalam pengiriman adalah merubah data menjadi yang tidak dimengerti dengan cara di sisipkan ke dalam pixel yang dinamakan teknik steganografi. Pada Teknik steganografi ini salah satu metode yang dapat di gunakan adalah metode Modified Least Significant Bit (MLSB). MLSB merupakan pengembangan dari metode LSB yaitu dengan memodifikasi data dengan cara merubah dari 8 bit menjadi 5 bit. Selain metode MLSB tersebut kita juga dapat menggunakan fungsi hash MD5 sebagai tambahan pengamanan. Dengan menggunakan fungsi hash MD5 serta dengan menggunakan metode MLSB (modified least significat bit) ini kualitas dari file citra yang di hasilkan menunjukkan nilai baik karena dari rata - rata nilai dari gambar sampel dengan nilai MSE 0.0037 serta PSNR di atas 60db.
Pengembangan Sistem Lective Untuk Laporan Kurikulum Perguruan Tinggi (Studi Kasus : Universitas Muhammadiyah Malang)
Authors: Fitriani Febri Ayu , Marthasari Gita Indah , Wicaksono Galih Wasis 
Published: July 2024

Pengembangan sistem Lective selalu diupayakan untuk memajukan segala aspek dalam sistem pendidikan guna memudahkan proses belajar mengajar dan memberikan pelayanan. Salah satunya laporan hasil perumusan kurikulum untuk memudahkan proses identifikasi dan pengendalian oleh program studi. Laporan progres penyusunan RPS dan notifikasi dapat bermanfaat sebagai pemantauan dan mengevaluasi perkembangan atau progres penyusunan kurikulum yang dilakukan oleh masing-masing dosen pengampu mata kuliah, sehingga kinerja dosen maupun program studi lebih terkontrol. Pengembangan dilakukan dengan menggunakan analisa kualitatif dan mencari pengujian solusi menggunakan proses BPI (Business Process Improvement). Pengujian dilakukan menggunakan Black Box Testing dengan menyusun skenario uji serta menerapkan pengujian fungsionalitas setelah pengembangan sistem. Hasil yang didapatkan yaitu notifikasi pada dashboard dosen berupa tanggat tenggat waktu dan nilai persentase progress kumulatif penyusunan RPS, halaman progress persentase penyusunan masing-masing dosen pengampu, dan progress RPS seluruh dosen. Dari pengujian yang dilakukan, pengembangan sistem dikatakan tidak menggangu fungsionalitas sistem sebelumnya, namun dalam pencocokan nilai persentasi yang didapat sistem membutuhkan penggalian lebih dalam untuk sesuai dengan penilaian pakar.
Rancang Bangun Sistem Informasi Pada Tabungan Bank Sampah Bantur Berseri
Authors: Kusuma Yannu Indra , Syafa'ah Lailis , Suharso Wildan 
Published: July 2024

Bank Sampah Bantur Berseri merupakan tempat menabung dimana seseorang menggunakan sampah sebagai tabungan dan sampah yang ditabung dikonversikan menjadi nilai uang. Sampah tersebut sudah ditetapkan harga oleh petugas bank sampah. Permasalahan pada bank sampah Bantur Berseri adalah petugas masih sering kerepotan dalam hal transaksi tabungan dan pembuatan laporan.Selain itu harga sampah dan jenisnya sering tertukar karena sering berubah. Petugas juga kesulitan dalam hal pencarian data nasabah serta tidak adanya backup data yang baik pada tabungan nasabah. Pada penelitian ini solusi yang diusulkan yaitu pembuatan sistem informasi pada tabungan bank sampah Bantur Berseri agar dapat membantu pengelolaan data transaksi nasabah sehingga adminstrasi lebih teratur, pencarian data lebih mudah dan arsip laporan lebih rapi. Pengembangan sistem menggunankan metode prototype.tt
Analisis Tingkat Kesiapan Pengguna Ensiklopedia Anak Dengan Menggunakan Metode Technology Readiness Index
Authors: Kristy Rellanti Diana , Wahyuni Evi Dwi , Hayatin Nur 
Published: July 2024

Anapedia merupakan sebuah teknologi baru sehingga memerlukan pengukuran tingkat kesiapan penggunanya. Pengukuran tersebut bertujuan untuk mengetahui tingkat keberhasilan penerapaan anapedia. Metode yang digunakan untuk mengukur tingkat kesiapan pengguna adalah Technology Readinesss Index (TRI). TRI merupakan indeks yang digunakan untuk mengukur kesiapan pengguna dalam menerima dan menggunakan teknologi baru untuk mencapai tujuan dalam kehidupan sehari-hari dan pekerjaan. Variabel penelitian yang digunakan adalah optimism, innovativeness, discomfort, dan insecurity. Analisis data yang digunakan adalah statistik inferensial yaitu metode statistik untuk mengumpulkan, mengolah, menyajikan dan menganalisis data kuantitatif. Data penelitian didapatkan dari penyebaran kuesioner kepada 108 responden yang terdiri dari 97 siswa dan 11 guru di SDN 2 Bandungrejosari Malang. Berdasarkan hasil analisis yang dilakukan didapatkan nilai TRI sebesar 3,6 yang berarti pengguna berada didalam tingkat high technology readiness. Pengguna sudah siap dalam penerapan anapedia.
Rancang Bangun Sistem Informasi Rekam Medis Menggunakan Model Rapid Application Development (RAD)
Authors: Amin Muhammad , Maskur Maskur , Suharso Wildan 
Published: July 2024

Sistem rekam medis Rumah Sakit Wijaya Kusuma Lumajang digunakan untuk mengelola data rekam medis yang meliputi data pendaftaran dan data medis pasien. Dimana sistem rekam medis yang digunakan ada saat itu sudah tidak sesuai dengan kebutuhan petugas rekam medis saat ini, sehingga dibuatkan sistem yang baru khusus bagian rekam medis yang sesuai dengan kebutuhan petugas rekam medis dengan cara menambahkan dokumen elisitasi agar supaya sesuai dengan kebutuhan petugas rekam medis. Sistem tersebut berbasis website dengan menggunakan model pengembangan perangkat lunak Rapid Application Development (RAD) dengan adanya penambahan fitur perhitungan rekam medis otomatis yang dulunya perhitungan tersebut dilakukan secara manual, fitur untuk menampilkan diagram rekam medis, dan fitur kode ICD10 dan ICD 9 yang lebih lengkap sesuai dengan buku kamus besar kode rekam medis. Pengujian sistem rekam medis ini nantinya akan di uji dengan menggunakan pengujian Blackbox Testing dan pengujian User Acceptance Test (UAT). Sistem rekam medis yang dibuat dan kembangkan sudah digunakan pihak bagian rekam medis rumah sakit sampai saat ini.