bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbubbles shunting via a patent foramen ovale impair endothelial function
Authors: Fok Henry , Jiang Benyu , Chowienczyk Phil , Clapp Brian 
Published: August 2015

Objectives Exposure to intravascular microbubbles after diving and during medical procedures alters endothelial function. The aim of this study was to investigate whether a patent foramen ovale altered forearm endothelial function by facilitating microbubbles transfer. Design Patients attended on two separate visits, at least seven days apart receiving agitated saline or no active intervention in random order. On both days, flow-mediated dilatation of the brachial artery was measured using vascular ultrasound. On the intervention visit, agitated saline was injected and the passage of microbubbles into the arterial circulation was confirmed by echocardiography. Serial flow-mediated dilatation measurements were made after agitated saline and at the same time points after no intervention. Setting St Thomas’ Hospital in London. Participants Patients with a patent foramen ovale (PFO+n = 14, 9 male, mean ± SD age 42.2 ± 10.5 years) and patients without a patent foramen ovale (PFO− n = 10, 7 male, mean ± SD age 49.4 ± 18.4 years) were recruited. Main outcome measures Change in brachial artery flow-mediated dilatation. Results In patent foramen ovale + patients, flow-mediated dilatation did not change significantly on the control day but after agitated saline reduced by 2.3 ± 0.3%, 20 minutes after bubble injection ( P < 0.005 vs. corresponding change in flow-mediated dilatation during control study). There was no significant change in flow-mediated dilatation for patent foramen ovale− patients at either visit. Conclusion These results suggest that the presence of a patent foramen ovale facilitated impairment of endothelial function acutely by the transfer of microbubbles into the arterial circulation. As a patent foramen ovale is a common condition, this may be relevant to microbubbles exposure in medical procedures and in decompression illness.
New crystal-chemical data for marécottite
Authors: Plášil J. , Škoda R. 
Published: August 2015

AbstractMarécottite, ideally Mg3[(UO2)4O3(OH)(SO4)2]2(H2O)28, a triclinic, Mg-dominant member of the zippeite group, was described originally from a small uranium deposit at La Creusaz in Wallis (Switzerland). It has recently been found at Jáchymov (Czech Republic), where it forms exceptional crystals, up to 0.3 mm across. According to an electron microprobe study of these crystals, marécottite from Jáchymov is chemically similar to the material from the La Creusaz deposit. However, the Jáchymov crystals exhibit more cation substitution (Zn2+and Mn2+for Mg2+). The chemical composition of marécottite from Jáchymov corresponds to the empirical formula [(Na0.05K0.07)Σ0.12(Mg1.83Zn0.41Mn0.41Cu0.15Ni0.08)Σ2.88Al0.07]Σ3.07(UO2)8[(SO4)3.77(SiO4)0.21]Σ3.98O6(OH)1.84·28H2O (the mean of four representative spots; calculated on the basis of eight U atoms and 28 H2O per formula unit and 1.84 OH for charge balance). According to single-crystal X-ray diffraction, marécottite from Jáchymov is triclinic,P1,a= 10.8084(2),b= 11.2519(3),c= 13.8465(3) Å, α = 66.222(2), β = 72.424(2), γ = 70.014(2)o,V= 1421.57(6) Å3 andZ= 1. The crystal structure was refined from a highly redundant dataset (30,491 collected reflections) toR1= 0.0367 for all 7042 unique reflections. The refined structure confirms the previously determined structure for the crystal from the La Creusaz deposit. An extensive network of hydrogen bonds is an important feature that keeps the whole structure together, but the positions of H atoms had not been determined previously. The H-bond scheme proposed based on a detailed bond-valence analysis and the role of different types of molecular H2O in the structure is discussed.
Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice
Authors: Decouture Benoit , Dreano Elise , Belleville-Rolland Tiphaine , Kuci Orjeta , Dizier Blandine , Bazaa Amine , Coqueran Bérard , Lompre Anne-Marie , Denis Cécile V. , Hulot Jean-Sébastien , Bachelot-Loza Christilla , Gaussem Pascale 
Published: August 2015

Key PointsIn vivo and in vitro thrombus formation is altered in MRP4-deficient mice. MRP4 modulates the cAMP–protein kinase A platelet signaling pathway.
Gene expression signatures of breast cancer stem and progenitor cells do not exhibit features of Warburg metabolism
Authors: Gordon Nicole , Skinner Amy M. , Pommier Rodney F. , Schillace Robynn V. , O’Neill Steven , Peckham Jennifer L. , Muller Patrick , Condron Mary E. , Donovan Cory , Naik Arpana , Hansen Juliana , Pommier SuEllen J. 
Published: August 2015

Abstract
Introduction
Cancers are believed to adapt to continual changes in glucose and oxygen availability by relying almost exclusively on glycolytic metabolism for energy (i.e. the Warburg effect). The process by which breast cancers sustain growth in avascular tissue is thought to be mediated via aberrant hypoxia response with ensuing shifts in glycolytic metabolism. Given their role in initiating and perpetuating tumors, we sought to determine whether breast cancer stem and progenitor cells play an instrumental role in this adaptive metabolic response.

Methods
Breast cancer stem/progenitor cells were isolated from invasive ductal carcinomas, and benign stem cells (SC) were isolated from reduction mammoplasty tissues. Relative expression of 33 genes involved in hypoxia and glucose metabolism was evaluated in flow cytometrically isolated stem and progenitor cell populations. Significance between cohorts and cell populations was determined using Student’s 2-tailed t test.

Results
While benign stem/progenitor cells exhibited few significant inter-group differences in expression of genes involved in hypoxia regulation or glucose metabolism, breast cancer stem/progenitor cells demonstrated significant inter-group variability. Breast cancer stem/progenitor cells adapted to microenvironments through changes in stem cell numbers and transcription of glycolytic genes. One of four breast cancer stem/progenitor cells subpopulations exhibited an aerobic glycolysis gene expression signature. This subpopulation comprises the majority of the tumor and therefore best reflects invasive ductal carcinoma tumor biology. Although PI3K/AKT mutations are associated with increased proliferation of breast cancer cells, mutations in breast cancer stem/progenitor cells subpopulations did not correlate with changes in metabolic gene expression.

Conclusions
The adaptive capacity of breast cancer stem/progenitor cells may enable tumors to survive variable conditions encountered during progressive stages of cancer growth.
Global sourcing: new research and education agendas for apparel design and merchandising
Authors: Ha-Brookshire Jung 
Published: August 2015

AbstractIn response to the dominance of global sourcing in the apparel industry within developed economies, this paper illustrates how the topic of global sourcing could help direct agendas for future research and education within the apparel discipline. By reviewing major functions of apparel design, product development, merchandising, and marketing in consideration of global sourcing, this paper shows how global sourcing could help designers and product developers make better decisions of fiber choices, better understand tradeoffs users may make between different raw materials, and become more aware of product performance requirements and design compliance issues. It illustrates how research on global sourcing would help merchandisers become more effective forecasters, planners, and implementers in this highly unpredictable marketplace. Marketing professionals will also learn to work with global sourcers to ensure transparency and integrity of their messages within the legal and ethical frameworks. A discussion on future research questions and educational goals follows.
Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1
Authors: Naval-Macabuhay Isaac , Casanova Víctor , Navarro Gemma , García Felipe , León Agathe , Miralles Laia , Rovira Cristina , Martinez-Navio José M , Gallart Teresa , Mallol Josefa , Gatell José M , Lluís Carme , Franco Rafael , McCormick Peter J , Climent Núria 
Published: August 2015

Abstract
Regulatory T cells have an important role in immune suppression during HIV-1 infection. As regulatory T cells produce the immunomodulatory molecule adenosine, our aim here was to assess the potential of adenosine removal to revert the suppression of anti-HIV responses exerted by regulatory T cells. The experimental setup consisted of ex vivo cocultures of T and dendritic cells, to which adenosine deaminase, an enzyme that hydrolyzes adenosine, was added. In cells from healthy individuals, adenosine hydrolysis decreased CD4+CD25hi regulatory T cells. Addition of 5′-N-ethylcarboxamidoadenosine, an adenosine receptor agonist, significantly decreased CD4+CD25lo cells, confirming a modulatory role of adenosine acting via adenosine receptors. In autologous cocultures of T cells with HIV-1-pulsed dendritic cells, addition of adenosine deaminase led to a significant decrease of HIV-1-induced CD4+CD25hi forkhead box p3+ cells and to a significant enhancement of the HIV-1-specific CD4+ responder T cells. An increase in the effector response was confirmed by the enhanced production of CD4+ and CD8+ CD25−CD45RO+ memory cell generation and secretion of Th1 cytokines, including IFN-γ and IL-15 and chemokines MIP-1α/CCL3, MIP-1β/CCL4, and RANTES/CCL5. These ex vivo results show, in a physiologically relevant model, that adenosine deaminase is able to enhance HIV-1 effector responses markedly. The possibility to revert regulatory T cell-mediated inhibition of immune responses by use of adenosine deaminase, an enzyme that hydrolyzes adenosine, merits attention for restoring T lymphocyte function in HIV-1 infection.
High-resolution ground-penetrating radar profiles of perennial lake ice in the McMurdo Dry Valleys, Antarctica: Horizon attributes, unconformities, and subbottom penetration
Authors: Dugan Hilary A. , Arcone Steven A. , Obryk Maciej K. , Doran Peter T. 
Published: August 2015

Ground-penetrating radar (GPR) is not commonly used to study lake ice, and in general, the ground-based use of radar frequencies greater than 500 MHz in cryosphere geophysics is rare, due to a general interest in deeper stratigraphy and the difficulty of extensive profiling over rough snow surfaces. Our goal was to find further information on the origin of the deposition and formation of intra-ice layers, bottom topography, and subbottom deposits using GPR with pulses centered near 850 MHz on two permanently ice-covered lakes in the McMurdo Dry Valleys, Antarctica. The profiles were obtained using a one-person sled operation over Lake Bonney, which is typical of lakes in the region, having an ice thickness that ranges between 3 and 5 m, and Lake Vida, where the maximum ice depth is at least 27 m. Lake Bonney exhibits a semicontinuous sediment horizon at approximately a 2-m depth and several minor horizons. In contrast, Lake Vida contains unconformably eroded and folded continuous reflection horizons, packages of minor horizons between major horizons, evidence of incised fluvial deposition along the bottom, and subbottom penetration of at least 4.5 m in some areas. Where the ice thickness is less than 20 m, the lake is frozen to the bottom. Most horizon waveform phase attributes indicate relatively lower permittivity than in the surrounding matrix. Consequently, we interpreted these strata to be caused by layers of pure ice embedded within a salty and dirty ice matrix, which were formed during minor flooding. These findings supported previous conclusions that Lake Vida ice formed from surface runoff in combination with periods of ablation.
In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine
Authors: Hu Liwei , Xu Wen , Zhang Xi , Su Juan , Liu Xinru , Li Haiyun , Zhang Weidong 
Published: August 2015

Abstract

Objectives
The effects of nuciferine, a major active aporphine alkaloid from the leaves of Nelumbo nucifera Gaertn, on a cytochrome P450 1A2 (CYP1A2) probe substrate were investigated in vitro and in vivo.

Methods
Nuciferine and recombinant human CYP1A2 were incubated together to study the impact of nuciferine on CYP1A2 in vitro. Nuciferine was administered orally to Wistar rats at a dose of 20 mg/kg to further estimate the impact of nuciferine on CYP1A2 in vivo. A probe substrate, phenacetin, was used to index the activity of CYP1A2.

Key findings
The IC50 value for nuciferine was determined to be 2.12 mmol/l. When phenacetin was intravenously coadministered with nuciferine compared with phenacetin alone, the elimination rate constant and total body clearance of phenacetin were decreased by 24.0% (P &lt; 0.01) and 43.0% (P &lt; 0.05), respectively. The mean residence time, apparent elimination half-time and area under the plasma concentration–time curve were increased by 22% (P &lt; 0.005), 26.9% (P &lt; 0.02) and 74.6% (P &lt; 0.05), respectively. Similarly, when phenacetin was coadministered orally with nuciferine, the apparent elimination half-time in the nuciferine pretreated group was increased by 16.7% (P &lt; 0.05) and the elimination rate constant was decreased by 15.4% (P &lt; 0.05).

Conclusions
The results suggest that nuciferine inhibited CYP1A2 activity in vitro and caused changes in the pharmacokinetic parameters of phenacetin in vivo.
A Tunable Superwetting Copper Film between Superhydrophobicity and Superhydrophilicity
Authors: Yan Ningbo , Li Jing , Guo Zhiguang , Xu Jiansheng 
Published: August 2015

Abstract
In this paper, it was intriguing to discover that drying condition played an important role in the superwettability properties of the copper film. Importantly, we successfully realized the unique copper film with reversible superwettabilities by solution stimulation, which can be employed as a kind of new engineering intelligent switchable material.
The role of connective tissue in the embryology of the musculoskeletal system: towards a paradigm shift
Authors: Marchuk Carolina , Stecco Carla 
Published: August 2015

This paper presents a review of literature regarding the role of embryological connective tissue in the formation of muscles and the organization of the musculoskeletal system. The intention is to introduce a potential paradigm shift with regards to understanding peripheral coordination of movement and movement patterns. This new perspective could improve comprehension of the normal physiological function of connective tissue and, whenever it is pathological, resultant symptoms. Furthermore, this paper briefly discusses some implications of this paradigm shift in the interpretation of movement patterns, posing further questions for future research.
A Japanese booklet about palliative care for advanced dementia in nursing homes
Authors: Nakanishi Miharu , Miyamoto Yuki , Long Carol O , Arcand Marcel 
Published: August 2015

Background A Canadian guide for nursing home staff on comfort care for dementia has been translated and adapted for use in Japan. The present study piloted educational intervention for nursing home staff using the Japanese comfort care booklet. Method Some 61 nursing home staff (nurses and other care workers) completed a session that included pre-assessment, a 30-minute seminar using the comfort care booklet, post-assessment, and a one-hour debriefing meeting. A Japanese version of the questionnaire on palliative care for advanced dementia (qPAD) scale was used to assess knowledge and attitudes toward palliative care for advanced dementia. Results The participants demonstrated a significant increase in knowledge (mean score, 14.3 to 15.1/23, t (60) = 2.35, p=0.011) and attitudes (43.8 to 45.2/60, t (60) = 2.51, p = 0.015) toward palliative care for advanced dementia from pre-assessment to post-assessment. Conclusion The educational intervention using the Japanese comfort care booklet may have improved nursing home staff's perspectives on palliative care for advanced dementia.
Examining the contribution of social media in reinforcing political participation in Zimbabwe
Authors: Mutsvairo Bruce , Sirks Lys-Anne 
Published: August 2015

Abstract
It normally is assumed that new media activism, in the wake of the ‘Arab Spring’ political protests in the Middle East, has the potential to promote and effectively enable social and political changes in contemporary societies. However, nowhere does the influence of the digital explosion appear somehow exaggerated as in the case of Africa, where lack of empirical evidence has seen policy-makers, commentators and journalists making extraordinary conclusions justifying the Internet’s perceived potential to shape political processes on the continent. This article questions this notion through an online ethnographic assessment of Zimbabwean blogger Baba Jukwa’s Facebook webpage, which became a prominent platform for the anti-Robert Mugabe establishment up until its sudden withdrawal from the web in August 2014. At its peak, the webpage became a meeting point for activists opposed to Zimbabwe’s long-time president as the anonymous blogger shared what he (assuming he was a man) claimed were juicy state secrets with the rest of the world. His pronouncements especially ahead of the 2013 elections gave hope to opposition campaigners that the era of a man, who has ruled Zimbabwe since 1980, was coming to an abrupt end. Calls were then made suggesting that the presence of the historic page was buttressing democratic participation as Zimbabweans from across the world converged on the blog discussing issues of mutual interest. The findings of our research, however, give a different picture, concluding rather that in spite of the page’s ability to encourage Zimbabweans to openly discuss and share thoughts, there simply is no evidence that Baba Jukwa had helped facilitate increased democratic participation in the country.
The making of cooperation
Authors: Panagiotara Betina 
Published: August 2015

Abstract
This article explores the terms “collaboration” and “cooperation” as practices, through the examination of the project Syros: A bet on the potentiality of cooperation, which took place in Syros, Greece, in July 2013. In particular, it describes the process of cooperating in practical terms and reflects on the conditions of production created by the project. For this purpose, it focuses on two of its essential components: namely, the structure of the project and the space of encounters it generated. The aim is to contribute to larger discussions on collaborative artistic practices through disclosing and studying the dynamics detected in a specific case study.
In memoriam: Petra Veber Rojnik (1972-2015)
Authors: Lah Jaka 
Published: August 2015

Abstract
As an actress, Petra Veber Rojnik created a number of unforgettable roles, in both institutional and non-institutional theatre projects. She drew the attention of the theatre public very early on, at the very beginning of her creative path, when she astonished with a series of experimental projects created within the collective of the E.P.I. Centre cultural and production institute and marked by an exploratory élan and a fresh, uncompromising aesthetics.
Resistance against aestheticisation of resistance
Authors: Jelesijević Nenad 
Published: August 2015

Abstract
Through an analysis of a well-publicised intervention into the exhibition Socialdress – Power to the People in October 2013 at the Alkatraz Gallery, which operates within Autonomous Cul¬tural Centre Metelkova City in Ljubljana, the article argues that mainstream artwork cannot stay sheltered from protest (re)ac¬tions solely thanks to the fact that it is part of the hegemony of the art system. Namely, in the context of the movement towards increasingly radical capitalist devastation, a link is established between numerous manifestations of resistance, including the protest against the commodification of popular uprisings’ slogans, which opens up the perspective of understanding art as a phenomenon without the status of difference, which would grant it any kind of privilege.
Keep on asking, betting, cooperating: Introduction
Authors: Georgelou Konstantina , Protopapa Efrosini , Theodoridou Danae 
Published: August 2015

Abstract
The editorial note unfolds the main aims and the particular working conditions of the project that has led to the specific publication. Syros: a bet on the potentiality of cooperation (2013) was organized as a co-writing encounter among performance artists and theorists from all over Europe. During an eight-days long writing residency the participants shared their individual topics of interest regarding contemporary performance as well as their distinct writing practices. Following that process, they also suggested an alternative mode for the creators of this publication, based not on a common topic (as is often the case) but on the “topos”, the place of encounter of its writers, which is seen as a “bet on the potentiality of cooperation” (Laermans).
Nostalgia for the present: Historical time in there contemporary performances
Authors: Cate Floor Houwink ten 
Published: August 2015

Abstract
The essay discusses how The Artist Is Present (2010) by Marina Abramović, The Show Must Go On (2001) by Jérome Bel and The Happiest Man (2000) by Ilya and Emilia Kabakov relate to the ‘nostalgia for the present’ of European and North American late capitalist societies of the spectacle. The works are firstly explored through the ways in which the artists “stage the present” by manipulating the presence and liveness of both themselves and their spectators, and secondly, how these “stagings of the present” consequently influence one’s perception of duration and the passage of time.