bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian abnormalities in mouse models of smith–magenis syndrome: Evidence for involvement of RAI1
Authors: Lacaria Melanie , Gu Wenli , Lupski James R 
Published: May 2013

AbstractSmith–Magenis syndrome (SMS; OMIM 182290) is a genomic disorder characterized by multiple congenital anomalies, intellectual disability, behavioral abnormalities, and disordered sleep resulting from an ∼3.7 Mb deletion copy number variant (CNV) on chromosome 17p11.2 or from point mutations in the gene RAI1. The reciprocal duplication of this region results in another genomic disorder, Potocki–Lupski syndrome (PTLS; OMIM 610883), characterized by autism, intellectual disability, and congenital anomalies. We previously used chromosome‐engineering and gene targeting to generate mouse models for PTLS (Dp(11)17/+), and SMS due to either deletion CNV or gene knock‐out (Df(11)17‐2/+ and Rai1+/−, respectively) and we observed phenotypes in these mouse models consistent with their associated human syndromes. To investigate the contribution of individual genes to the circadian phenotypes observed in SMS, we now report the analysis of free‐running period lengths in Rai1+/− and Df(11)17‐2/+ mice, as well as in mice deficient for another known circadian gene mapping within the commonly deleted/duplicated region, Dexras1, and we compare these results to those previously observed in Dp(11)17/+ mice. Reduced free‐running period lengths were seen in Df(11)17‐2/+, Rai1+/−, and Dexras1−/−, but not Dexras1+/− mice, suggesting that Rai1 may be the primary gene underlying the circadian defects in SMS. However, we cannot rule out the possibility that cis effects between multiple haploinsufficient genes in the SMS critical interval (e.g., RAI1 and DEXRAS1) either exacerbate the circadian phenotypes observed in SMS patients with deletions or increase their penetrance in certain environments. This study also confirms a previous report of abnormal circadian function in Dexras1−/− mice. © 2013 Wiley Periodicals, Inc.
Niche production strategies and shell matrix site variability at Albatross Bay, Cape York Peninsula
Authors: Morrison Michael 
Published: May 2013

AbstractAlbatross Bay, near Weipa on western Cape York Peninsula, is well known for the large number of anthropogenic late Holocene shell mound sites that occur in the region. Recent research on shell mound formation and use both here and elsewhere across northern Australia has focused upon the extent to which mound formation may have been tied to intensive use of periodically available gluts of the intertidal bivalve Anadara granosa. This paper explores whether such a model applies in the Albatross Bay region, drawing on data available from 477 shell matrix sites recorded in this region. Data on site size, morphology, composition, substrate type, proximity to contemporary shorelines and shell mound chronology support a model of Aboriginal people episodically and strategically targeting a highly variable niche estuarine resource base rather than intensively focusing on one species. It is proposed that these production strategies were characterised by a high degree of flexibility in terms of resource focus, at times involving a considerable emphasis on A. granosa, but also incorporating other estuarine resources, and that the level or intensity of production was able to be scaled up or down in line with resource availability and abundance. This production system was based upon nuanced knowledge of annual and intra‐annual ecosystem dynamics along with social organisation and communication networks that facilitated a high degree of flexibility around the strategic exploitation of variable estuarine resource bases.
Rational Heme Protein Design: All Roads Lead to Rome
Authors: Lin Ying‐Wu , Sawyer Elizabeth B. , Wang Jiangyun 
Published: May 2013

AbstractHeme proteins are among the most abundant and important metalloproteins, exerting diverse biological functions including oxygen transport, small molecule sensing, selective CH bond activation, nitrite reduction, and electron transfer. Rational heme protein designs focus on the modification of the heme‐binding active site and the heme group, protein hybridization and domain swapping, and de novo design. These strategies not only provide us with unique advantages for illustrating the structure–property–reactivity–function (SPRF) relationship of heme proteins in nature but also endow us with the ability to create novel biocatalysts and biosensors.
Antioxidant activity, lipophilicity and extractability of polyphenols from pig skin – development of analytical methods for skin permeation studies
Authors: Zillich Olesya V. , Schweiggert‐Weisz Ute , Hasenkopf Katrin , Eisner Peter , Kerscher Martina 
Published: May 2013

ABSTRACTPermeation of polyphenols through the stratum corneum barrier is a precondition for the protective action of polyphenols against oxidative skin damage. Prior to in vitro skin permeation experiments, we developed a method for the quantification of polyphenols in pig skin, including organic solvent extraction and HPLC analysis. Catechine hydrate, epigallocatechin gallate, trans‐resveratrol, quercetin, rutin and protocatechuic acid were chosen for this study as representatives of phenolics with different lipophilicity and molecular weight. The antioxidative activities of polyphenols as well as their octanol–water partition coefficients at different pH values were determined. Extraction of polyphenols from pig skin was optimized by variation of solvent composition, homogenization intensity and time, as well as partial exclusion of oxygen during extraction. The highest recovery rates could be reached by extraction with the methanol–water mixture (90:10, v/v), containing 0.2 g/L l‐ascorbic acid, after the cryo‐milling for 4 min. Recoveries of 72% for total phenolics, 96% for quercetin and protocatechuic acid, 90% for rutin and 74% for trans‐resveratrol, were achieved. These extraction parameters will be selected for the polyphenol extraction from pig skin for further in vitro drug permeation studies. Copyright © 2013 John Wiley & Sons, Ltd.
ChemInform Abstract: Structural Characterization of the Perovskite Series Sr1‐xLaxTi0.5Mn0.5O3.
Authors: Qasim Ilyas , Kennedy Brendan J. 
Published: May 2013

AbstractThe perovskites Sr1‐xLaxTi0.5Mn0.5 O3, x = 0, 0.1, 0.2, 0.3, 0.4 and 0.5 are synthesized by solid state reaction of La2O3, SrCO3, TiO2, and MnCO3 (1350—1450 °C, 2 d).
ChemInform Abstract: Crystal Structure and Properties of High‐Pressure‐Synthesized BiRhO3, LuRhO3, and NdRhO3.
Authors: Yi Wei , Liang Qifeng , Matsushita Yoshitaka , Tanaka Masahiko , Hu Xiao , Belik Alexei A. 
Published: May 2013

AbstractBiRhO3 (I), LuRhO3 (II), and NdRhO3 (III) are prepared by solid state reaction of stoichiometric mixtures of M2O3 (M: Bi, Lu, Nd) and Rh2O3 (Au capsules, 6 GPa, 1600 °C for (I), 1300 °C for (II) and (III), 2 h).
ChemInform Abstract: Structure and Optical Properties of Cubic Gallium Oxynitride Synthesized by Solvothermal Route.
Authors: Oberlaender Andreas , Kinski Isabel , Zhu Wenliang , Pezzotti Giuseppe , Michaelis Alexander 
Published: May 2013

AbstractCubic gallium oxynitride is synthesized by solvothermal processing of a gallium ethylene diamine complex and H2O (autoclave, 200 °C, 1 d).
ChemInform Abstract: New Bismuth Selenium Oxides: Syntheses, Structures, and Characterizations of Centrosymmetric Bi2(SeO3)2(SeO4) and Bi2(TeO3)2(SeO4) and Noncentrosymmetric Bi(SeO3)(HSeO3).
Authors: Lee Eun Pyo , Song Seung Yoon , Lee Dong Woo , Ok Kang Min 
Published: May 2013

AbstractThe new title compounds are structurally characterized by single crystal XRD.
ChemInform Abstract: Asymmetric, Regioselective Bromohydroxylation of 2‐Aryl‐2‐propen‐1‐ols Catalyzed by Quinine‐Derived Catalysts.
Authors: Zhang Ye , Xing Hui , Xie Weiqing , Wan Xiaolong , Lai Yisheng , Ma Dawei 
Published: May 2013

AbstractA first example of an enantioselective and regioselective bromohydroxylation of 2‐aryl‐2‐propen‐1‐ols is developed.
ChemInform Abstract: Synthesis of Planar Chiral [2.2]Paracyclophanyl Imidazo[1,5‐a]pyridinium Salts for the Rhodium‐Catalyzed Asymmetric Arylation.
Authors: Wang Dengxia , Ma Yudao , He Fuyan , Duan Wenzeng , Zhao Lei , Song Chun 
Published: May 2013

AbstractA series of novel planar‐chiral NHC precursors are synthesized and applied in the Rh‐catalyzed asymmetric 1,2‐addition of arylboronic acids to aromatic aldehydes.
ChemInform Abstract: Green and Scalable Aldehyde‐Catalyzed Transition Metal‐Free Dehydrative N‐Alkylation of Amides and Amines with Alcohols.
Authors: Xu Qing , Li Qiang , Zhu Xiaogang , Chen Jianhui 
Published: May 2013

AbstractAn efficient method for the N‐alkylation of various sulfonamides and amines with alcohols is developed (40 examples in all) using the corresponding aldehydes as the catalyst.
ChemInform Abstract: An Efficient Transesterification of β‐Oxodithioesters Catalyzed by Stannous Chloride under Solvent‐Free Conditions.
Authors: Devi Nepram Sushuma , Singh Sarangthem Joychandra , Singh Okram Mukherjee 
Published: May 2013

AbstractNotable features of the protocol include a short reaction time, mild conditions, and the use of an inexpensive catalyst.
ChemInform Abstract: Metalated N‐Heterocyclic Reagents Prepared by the Frustrated Lewis Pair TMPMgCl·BF3 and Their Addition to Aromatic Aldehydes and Activated Ketones.
Authors: Manolikakes Sophia M. , Jaric Milica , Karaghiosoff Konstantin , Knochel Paul 
Published: May 2013

AbstractTreatment of pyridines, quinoline and methylthiopyrazine with the frustrated Lewis pair TMPMgCl·BF3 leads to organofluoroborates which react readily with a variety of aromatic aldehydes or activated ketones (II) to the corresponding carbinols (III) in the absence of a transition metal catalyst.
ChemInform Abstract: An Eco‐Sustainable Green Approach for the Synthesis of Propargylamines Using LiOTf as a Reusable Catalyst under Solvent‐Free Condition.
Authors: Dindulkar Someshwar D. , Kwan Baek , Lim Kwon Taek , Jeong Yeon Tae 
Published: May 2013

AbstractThe electronic effects of the aldehyde substituents as well as the nature of the secondary amine are found to affect reaction rate and yield.
ChemInform Abstract: A Novel Route to Organonitrites by Pd‐Catalyzed Cross‐Coupling of Sodium Nitrite and Potassium Organotrifluoroborates.
Authors: Al‐Masum Mohammad , Saleh Nabil , Islam Tasfia 
Published: May 2013

AbstractMicrowave‐assisted Pd‐catalyzed coupling of sodium nitrite with styryltrifluoroborates produces the desired products in high yields.
ChemInform Abstract: Regio‐ and Stereospecific Synthesis of (E)‐α‐Iodoenamide Moieties from Ynamides Through Iodotrimethylsilane‐Mediated Hydroiodation.
Authors: Sato Akihiro H. , Ohashi Kazuhiro , Iwasawa Tetsuo 
Published: May 2013

AbstractUncatalyzed addition reaction of TmsI or TmsBr and subsequent careful hydrolysis offers a facile approach to the highly functionalized target units.
ChemInform Abstract: Enantioselective Synthesis of Planar Chiral Ferrocenes via Palladium‐Catalyzed Direct Coupling with Arylboronic Acids.
Authors: Gao De‐Wei , Shi Yan‐Chao , Gu Qing , Zhao Zheng‐Le , You Shu‐Li 
Published: May 2013

AbstractVarious arylated aminoethylferrocene derivatives (I) are prepared easily using the reaction with boronic acids.
ChemInform Abstract: Efficient Manganese/Copper Bimetallic Catalyst for N‐Arylation of Amides and Sulfonamides under Mild Conditions in Water.
Authors: Teo Yong‐Chua , Yong Fui‐Fong , Ithnin Idzham Khalid , Yio Siew‐Hui Trionna , Lin Zhiyin 
Published: May 2013

AbstractA facile, convenient and mild method for the synthesis of various of N‐arylamides and N‐arylsulfonamides is developed.
ChemInform Abstract: Rhodium‐Catalyzed Synthesis of 2,3‐Diaryl‐1,4‐diketones via Oxidative Coupling of Benzyl Ketones Using α‐Thioketone Oxidizing Reagent.
Authors: Arisawa Mieko , Li Guangzhe , Yamaguchi Masahiko 
Published: May 2013

AbstractThe dimerization of aryl benzyl ketones affords the required diones as diastereomeric mixtures where the racemic isomers are formed as main products.
ChemInform Abstract: Syntheses of Effectively‐Shielded N‐Heterocyclic Carbene Ligands.
Authors: Ando Shin , Matsunaga Hirofumi , Ishizuka Tadao 
Published: May 2013

AbstractNewly synthesized silver—carbene complexes are applied in the copper‐catalyzed allylic arylation of cinnamyl bromide with Grignard reagent (II) to form predominantly the gamma‐product (IV).
ChemInform Abstract: Enantioselective α‐Hydroxylation of β‐Ketoamides.
Authors: De Fusco Claudia , Meninno Sara , Tedesco Consiglia , Lattanzi Alessandra 
Published: May 2013

AbstractThe first enantioselective α‐hydroxylation of α‐substituted β‐ketoamides such as (I) is developed furnishing tertiary alcohols in good yield and up to 83% e.e.
ChemInform Abstract: Five‐Membered 2,3‐Dioxo Heterocycles. Part 91. Reaction of 3‐Aroyl‐1H‐pyrrolo[2,1‐c][1,4]benzoxazine‐1,2,4‐triones with Dimedone. Crystalline and Molecular Structure of 3′‐Benzoyl‐4′‐hydroxy‐1′‐ (2‐hydroxyphenyl)‐6,6‐dimethyl‐6,7‐dihydrospiro [1‐benzofuran‐3,2′‐pyrrole]‐2,4,5′(1′H,5H)‐trione.
Authors: Tutynina N. M. , Racheva N. L. , Maslivets V. A. , Aliev Z. G. , Maslivets A. N. 
Published: May 2013

AbstractThe molecular structure of compound (III) is proved by X‐ray analysis.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Ireland—Coates Claisen Rearrangement: Synthesis of Functionalized β‐Lactones.
Authors: Candish Lisa , Lupton David W. 
Published: May 2013

AbstractFormal [3 + 2]‐annulation is achieved between a range of α,β‐unsaturated acyl fluorides and cyclopropyl substrates bearing C2‐ and C4‐oxygenation.
ChemInform Abstract: Masked Amino Acid: A New C‐Nucleophile for I2‐Catalyzed Stereoselective Ring Opening of Epoxides in Ionic Liquid.
Authors: Rai Vijai K. , Sharma Roopali , Kumar Anil 
Published: May 2013

AbstractAminofuranones are prepared with excellent cis‐diastereoselectivity via ring‐opening of terminal epoxides and aminoacetylative cyclization.
ChemInform Abstract: Synthesis of 4,5,6,7‐Tetrahydro‐1H‐indole Derivatives Through Successive Sonogashira Coupling/Pd‐Mediated 5‐endo‐dig Cyclization.
Authors: Andreev Ivan A. , Belov Dmitry S. , Kurkin Alexander V. , Yurovskaya Marina A. 
Published: May 2013

AbstractThis is the first example of a Sonogashira coupling/cyclization sequence to yield C2‐aryl‐substituted 4,5,6,7‐tetrahydroindoles.
ChemInform Abstract: 1‐(2′‐Anilinyl)prop‐2‐yn‐1‐ol Rearrangement for Oxindole Synthesis.
Authors: Kothandaraman Prasath , Koh Bing Qin , Limpanuparb Taweetham , Hirao Hajime , Chan Philip Wai Hong 
Published: May 2013

AbstractNIS‐mediated synthesis of highly functionalized gem‐3‐(diiodomethyl)indolin‐2‐ones [cf.
ChemInform Abstract: Amino‐Directed RhIII‐Catalyzed C—H Activation Leading to One‐Pot Synthesis of N—H Carbazoles.
Authors: Jiang Qibai , Duan‐Mu Dandan , Zhong Wei , Chen Hao , Yan Hong 
Published: May 2013

AbstractThe reaction is not sensitive to the electronic and steric effects.
ChemInform Abstract: Synthesis of 1H‐Indazoles and 1H‐Pyrazoles via FeBr3/O2 Mediated Intramolecular C—H Amination.
Authors: Zhang Tianshui , Bao Weiliang 
Published: May 2013

AbstractThe reaction is proposed to proceed via single‐electron‐transfer from the substrate to FeBr3.
ChemInform Abstract: Microwave Irradiated Synthesis of Some Substituted Imidazole Derivatives (IV) as Potential Antibacterial and Anticancer Agents.
Authors: Sharma Gyanendra Kumar , Sharma Naveen Kumar , Pathak Devender 
Published: May 2013

AbstractAll the new aryl‐substituted imidazole derivatives (IV) (10 examples) show good antibacterial activity against gram‐negative bacterial strains and significant cytotoxicity against DLA and EAC cell lines.
ChemInform Abstract: Synthesis and Antimicrobial Evaluation of Novel Lipophilic Derivatives of Pyrazolylisoxazolines.
Authors: Chadha Shally , Khajuria Rajni , Paul Satya , Kapoor Kamal K. 
Published: May 2013

AbstractPyrazolylisoxazolines bearing cyclic or linear lipophilic groups (VI) and (IX), resp., are synthesized and tested for their antibacterial and antifungal activities.
ChemInform Abstract: Synthesis and Antimicrobial Activity of 3‐(2‐Thienyl) ‐4‐arylazo‐5‐hydroxy‐5‐trifluoromethyl‐Δ2‐isoxazolines and 3‐(2‐Thienyl)‐4‐arylazo‐5‐trifluoromethylisoxazolines.
Authors: Aggarwal Ranjana , Bansal Anshul , Mittal Arpana 
Published: May 2013

AbstractThe title compounds (IV) and (V) exhibit moderate to significant antibacterial activity against Gram‐positive bacteria and antifungal activity against S.
ChemInform Abstract: Metal‐Free Synthesis of 2‐Aminobenzoxazoles Using Hypervalent Iodine Reagent.
Authors: Wagh Yogesh S. , Tiwari Neelam J. , Bhanage Bhalchandra M. 
Published: May 2013

AbstractUncatalyzed ring‐opening of benzoxazoles with secondary amines and subsequent oxidative cyclization of the resulting imines with IBX as the oxidant offers a convenient access to the target compounds.
ChemInform Abstract: Alternative Simple and Effective Synthesis of (Di)benzoxanthones and Their Functions Toward Fluorescent Dyes.
Authors: Azuma Eriko , Kuramochi Kouji , Tsubaki Kazunori 
Published: May 2013

Abstract(Di)benzoxanthones are efficiently synthesized via dehydration of the corresponding dihydroxybenzophenone catalyzed simply by K2CO3 and their optical properties are investigated in MeOH.
ChemInform Abstract: Microwave‐Promoted Catalyst‐Free Benzylic C—H Functionalization of Methyl Quinoline and Michael Addition to β‐Nitrostyrene.
Authors: Rao N. Nageswara , Meshram H. M. 
Published: May 2013

AbstractFunctionalization of the C‐2 methyl group under conditions A) allows the rapid production of libraries containing quinoline derivatives for drug research.
ChemInform Abstract: Synthesis of Some Novel Pyrimidinedione and Pyrimidinetrione Derivatives by a Greener Method: Study of Their Antimicrobial Activity and Photophysical Properties.
Authors: Borse Bhushan Nanasaheb , Shukla Sanjeev Ramchandra , Sonawane Yogesh Ashok , Shankerling Ganpati Subray 
Published: May 2013

AbstractThe title compounds such as (III), (V), and (VII) are obtained by Knoevenagel condensation under classical, conventional condition, in the presence of a lipase biocatalyst or with a deep eutectic solvent (DES).
ChemInform Abstract: An Efficient, Ionic Liquid Mediated One‐Pot, Three Component Sequential Synthesis of 3‐Benzothiazolyl‐2‐styrylquinazolin‐4(3H)‐ones.
Authors: Kumar Mahendra , Sharma Kailash , Sharma Dinesh Kumar , Arya Anand Kumar 
Published: May 2013

AbstractAn eco‐compatible method is presented for the synthesis of title compounds (IV) (8 examples) through sequential reaction of benzoxazinone (II) with 2‐aminobenzothiazoles using the halogen‐free SO3H‐functionalized ionic liquid IMS as recyclable medium.
ChemInform Abstract: SnAP Reagents for the Transformation of Aldehydes into Substituted Thiomorpholines — An Alternative to Cross‐Coupling with Saturated Heterocycles.
Authors: Vo Cam‐Van T. , Mikutis Gediminas , Bode Jeffrey W. 
Published: May 2013

AbstractVarious unprotected thiomorpholine derivatives are efficiently synthesized in a one‐pot two‐step procedure from SnAP reagents (I) and (V).
ChemInform Abstract: An Efficient Synthesis and Biological Study of Substituted 8‐Chloro‐5‐methoxy/8‐Chloro‐4H‐1,4‐benzothiazines, Their Sulfones and Ribofuranosides.
Authors: Khandelwal Nishidha , Abhilasha Abhilasha , Gautam Naveen , Gautam D. C. 
Published: May 2013

AbstractNovel 1,4‐benzothiazines are synthesized and tested for their antimicrobial, antifungal, and anthelmintic activity.
ChemInform Abstract: The Chemistry of Mycotoxins
Authors: Braese S. , Glaeser F. , Kramer C. S. , Lindner S. , Linsenmeier A. M. , Masters K.‐S. , Meister A. C. , Ruff B. M. , Zhong S. 
Published: May 2013

AbstractReview: 789 refs.
Coalescence and Break‐Up in Bubble Columns: Euler‐Lagrange Simulations Using a Stochastic Approach
Authors: Gruber Michael C. , Radl Stefan , Khinast Johannes G. 
Published: May 2013

AbstractA systematic study of the impact of break‐up and coalescence (B&C) on the hydrodynamics in a bubble column is presented. A stochastic approach was chosen for the integration of various B&C kernels into a four‐way coupled Euler‐Lagrange model. The model is benchmarked against the Deen case, and good agreements were found for the gas holdup and the bubble size distribution. While the results indicate that monodisperse bubbles suffice to correctly forecast the flow features, B&C models are the key to predict the specific interfacial area especially in the lower half of the bubble column.
Simulation of Bubble Columns with a Compartment Model Approach
Authors: Abel Nils H. , Schlusemann Linda , Grünewald Marcus 
Published: May 2013

AbstractBlasensäulenreaktoren sind zwar mechanisch einfache Apparate, die in ihnen vorherrschenden Gas‐Flüssig‐Interaktionen sind aber bedeutend komplexer. Die Auslegung anhand des axialen Dispersionsmodells hat entscheidende Nachteile in der Beschreibung der komplexen Wechselwirkungen zwischen Gas‐ und Flüssigphase. Obwohl die numerische Strömungsmechanik in den letzten Jahren, auch aufgrund steigender Rechnerkapazitäten und ‐leistungen, sehr vielversprechende Fortschritte gemacht hat, ist die Berechnung des Betriebsverhaltens industrieller Blasensäulenreaktoren nicht verifizierbar. Als Alternative bieten sich eine Unterteilung des Reaktors in Teilbilanzräume an. Diese als Kompartment‐Modellierung bekannte Beschreibungsmethode wird im Rahmen des Beitrags erläutert und diskutiert.
Intramolecular Hydroalkoxylation of Non‐Activated CC Bonds Catalysed by Zeolites: An Experimental and Theoretical Study
Authors: Pérez‐Mayoral Elena , Matos Ines , Nachtigall Petr , Položij Miroslav , Fonseca Isabel , Vitvarová‐Procházková Dana , Čejka Jiří 
Published: May 2013

AbstractThe high activity and selectivity of zeolites in the cyclisation of unsaturated alcohols is reported for the first time; the details of a reaction mechanism based on quantum chemical calculations are also provided. The high efficiency of zeolites MFI, BEA and FAU in the cyclisation of unsaturated alcohols (cis‐decen‐1‐ol, 6‐methylhept‐5‐en‐2‐ol and 2‐allylphenol) to afford oxygen‐containing heterocyclic rings is demonstrated. The best catalytic performance is found for zeolites with the optimum concentration of Brønsted acid sites (ca. 0.2 mmol g−1) and the minimum number of Lewis acid sites. It is proposed that the efficiency of the catalysts is reduced by the existence of the so‐called dual site, at which a molecule of unsaturated alcohol can simultaneously interact with two acid sites (an OH group with one and the double bond with the other Brønsted site), which increases the interaction strength. The formation of such adsorption complexes leads to a decrease in the catalyst activity because of (i) an increase in the reaction barrier, (ii) an unfavourable conformation and (iii) diffusion limitations. A new procedure for the preparation of tetrahydrofurans and pyrans over zeolite catalysts provides important oxygen‐containing heterocycles with numerous applications.
Diastereoselective Synthesis of Isoindole‐Fused Diazacyclooctaindenones from Spiro­chromenes through Domino Reactions with Aliphatic 1,2‐Diamines
Authors: Pathak Sudipta , Pramanik Animesh 
Published: May 2013

AbstractA diastereoselective synthesis of isoindole‐fused diazacyclooctaindenone derivatives has been accomplished through tandem ring‐opening and ring‐closing of spirochromene derivatives triggered by different aliphatic 1,2‐diamines. When ethanolic solutions of spirochromenes are refluxed with different aliphatic 1,2‐diamines such as 1,2‐ethylenediamine, (±)‐1,2‐propylenediamine and (±)‐trans‐1,2‐cyclohexanediamine, the isoindole‐fused eight‐membered heterocycles are formed in moderate to high yields within 5–15 min.