bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Nuclear Nanomorphology Marker to Improve the Detection of Malignancy From Bile Duct Biopsy Specimens
Authors: Hartman Douglas J. , Krasinskas Alyssa M. , Uttam Shikhar , Staton Kevin , Bista Rajan , IIyas Sumera I , Slivka Adam , Brand Randall , Liu Yang 
Published: May 2014

Abstract

Objectives:
The accurate diagnosis of malignancy from small bile duct biopsy specimens is often challenging. This proof-of-concept study assessed the feasibility of a novel optical technology, spatial-domain low-coherence quantitative phase microscopy (SL-QPM), that assesses nanoscale structural alterations in epithelial nuclei for improving the diagnosis of malignancy in bile duct biopsy specimens.

Methods:
The SL-QPM analysis was performed on standard histology specimens of bile duct biopsy specimens from 45 patients. We analyzed normal cells with benign follow-up, histologically normal cells with pancreaticobiliary malignancy, and malignant epithelial cells.

Results:
The SL-QPM–derived nuclear nanomorphology marker can not only distinguish benign and malignant epithelial cells but can also detect features of malignancy in those cells normal by light microscopy with a discriminatory accuracy of 0.90. When combining pathology with SL-QPM, the sensitivity is improved to 88.5% from 65.4% of conventional pathology, while maintaining 100% specificity.

Conclusions:
SL-QPM–derived nuclear nanomorphology markers represent a novel approach for detecting malignancy from histologically normal-appearing epithelial cells, with potential as an adjunctive test in patients with negative or inconclusive pathologic diagnosis on bile duct biopsy specimens.
Vernacular masculinity and politics of space in contemporary Bollywood cinema
Authors: Sinha Suvadip 
Published: May 2014

Abstract
A series of popular Hindi films, specifically located in north-Indian small towns, not just depict a new spatiality through realist overtures; they also stage the appearance of a distinct form of masculinity on-screen. This article specifically looks at the representation and construction of masculine subjectivity in contemporary small-town films such as Dabangg (2010), Ishaqzaade (2012) and Gangs of Wasseypur I and II (2012) to analyse how this new spatiality is conjured through the re-configuration of non-urban manhood. Visibly distinctive bodily gestures, unique modes of consumption, often accompanied by localized dispensation, make it possible for these male characters to represent the in-between-ness of the small town. While the device of cinematic excess marks the representation of the vernacular space and its masculine inhabitant, such excess, this article further argues, enables the provincial India to appropriate its own discourses of legality, politics and community.
There is no way you can frame it. Ideias de Teatro e Cinema a partir de Michael Fried
Authors: Frazão Francisco 
Published: May 2014

Partindo do artigo "Art and Objecthood" (1967) de Michael Fried, analisam-se as ideias de teatro e cinema ali construídas, de forma a postular uma teatralidade cinematográfica imune ao preconceito antiteatral que muitas vezes carateriza os trabalhos sobre a interseção das duas artes. Dado o lugar tangencial do cinema em "Art and Objecthood", recorre-se a outros textos (muitos do mesmo período e sobretudo da linhagem dos Cahiers du Cinéma) para desmontar a ideia de cinema de Fried e fazer emergir uma nova. Duas cenas, uma de Godard e outra de Tsai Ming-liang, são usadas para exemplificar a teatralidade proposta.Abstract I analyze the concepts of theatre and film in Michael Fried's "Art and Objecthood" (1967), in order to argue for a cinematic theatricality immune to the anti-theatrical prejudice often found in works about the intersection of these two art forms. Given the tangential place of movies in Fried's article, other texts are used (mostly from the same period and mainly from the Cahiers du Cinéma tradition) to deconstruct Fried's idea of film so that a new concept can emerge. Two scenes, one from Godard and the other from Tsai Ming-liang, are used to illustrate the proposed theatricality. DOI: http://dx.doi.org/10.14195/2182-8830_1-2_6
Defect Prediction for New Products During the Development Phase
Authors: Chu Tao-Peng , Wang Fu-Kwun 
Published: May 2014

Abstract
Defect prediction is an important task in the development phase of new products. We present a new method of predicting the number of defects for new products in the computer industry, such as laptops, during the development phase. The proposed approach is based on robust regression and reliability growth models. We use a robust regression model to predict the number of defects for new products, and a growth model is used to track the test progress during the development phase. The Weibull growth model achieves the best fit compared with other models, such as the exponential, three-parameter logistic, and Gompertz model. The predicted defects for four example products are similar to the actual defects during the whole development phase. The Weibull growth curve also provides a good fit for monitoring defect trends.
Alterations in diurnal rhythmicity in patients treated for nonfunctioning pituitary macroadenoma: a controlled study and literature review
Authors: Joustra S D , Thijs R D , van den Berg R , van Dijk M , Pereira A M , Lammers G J , van Someren E J W , Romijn J A , Biermasz N R 
Published: May 2014

ObjectivePatients treated for nonfunctioning pituitary macroadenomas (NFMAs) have fatigue and alterations in sleep characteristics and sleep–wake rhythmicity frequently. As NFMAs often compress the optic chiasm, these complaints might be related to dysfunction of the adjacent suprachiasmatic nucleus (SCN). We aimed to explore whether indirect indices of SCN functioning are altered in the long term after surgery for NFMAs.MethodsWe studied 17 NFMA patients in long-term remission after transsphenoidal surgery, receiving adequate and stable hormone replacement for hypopituitarism, and 17 control subjects matched for age, gender, and BMI. Indirect indices of SCN function were assessed from 24-h ambulatory recordings of skin and core body temperatures, blood pressure, and salivary melatonin levels. Altered melatonin secretion was defined as an absence of evening rise, considerable irregularity, or daytime values >3 pg/ml. We additionally studied eight patients treated for craniopharyngioma.ResultsDistal–proximal skin temperature gradient did not differ between NFMAs and control subjects, but proximal skin temperature was decreased during daytime (P=0.006). Core body temperature and non-dipping of blood pressure did not differ, whereas melatonin secretion was often altered in NFMAs (OR 5.3, 95% CI 0.9–30.6). One or more abnormal parameters (≥2.0 SDS of control subjects) were observed during nighttime in 12 NFMA patients and during daytime in seven NFMA patients. Similar patterns were observed in craniopharyngioma patients.ConclusionHeterogeneous patterns of altered diurnal rhythmicity in skin temperature and melatonin secretion parameters were observed in the majority of patients treated for NFMAs. On a group level, both NFMA and craniopharyngioma patients showed a lower daytime proximal skin temperature than control subjects, but other group averages were not significantly different. The observations suggest altered function of central (or peripheral) clock machinery, possibly by disturbed entrainment or damage of the hypothalamic SCN by the suprasellar macroadenoma or its treatment.
Seasonal Difference in Percutaneous Absorption of N,N‐Dimethylformamide as Determined Using Two Urinary Metabolites
Authors: Tsuda Yoko , Miyauchi Hiroyuki , Minozoe Aoi , Tanaka Shigeru , Arito Heihachiro , Tsukahara Teruomi , Nomiyama Tetsuo 
Published: May 2014

Seasonal Difference in Percutaneous Absorption of N,N‐Dimethylformamide as Determined Using Two Urinary Metabolites: Yoko TSUDA, et al. Department of Preventive Medicine and Public Health, Shinshu University School of Medicine—ObjectiveWe evaluated the percutaneous absorption of N,N‐dimethylformamide (DMF) in DMF‐exposed workers in the summer and winter by assessing their urinary levels of DMF metabolites.MethodsBreathing‐zone concentrations of DMF and workers' urinary levels of N‐methylformamide (NMF) and N‐acetyl‐S‐(Nmethylcarbamoyl)‐cysteine (AMCC) were simultaneously measured in the summer and winter in 193 male workers wearing a respirator and chemical protective gloves.ResultsThe mean breathing‐zone concentrations of DMF in both seasons were below the occupational exposure limit of 10 ppm. Although there was no significant seasonal difference in the breathing‐zone concentrations of DMF, workers' urinary levels of NMF and AMCC were significantly higher in the summer than in the winter. Log‐transformed urinary levels of the metabolites were significantly correlated with log‐transformed breathing‐zone concentrations of DMF in the summer, whereas no significant correlation between AMCC and DMF was found in the winter. The urinary levels of AMCC were dispersed more widely than those of NMF, suggesting that urinary AMCC reflected the cumulative exposure to DMF over a workweek.ConclusionsPercutaneous absorption was the principal route of exposure to DMF for the respirator‐wearing workers. Increased urinary levels of NMF and AMCC in the summer were attributed to increased percutaneous absorption of DMF resulting from the increased amount of water‐soluble DMF absorbed by sweaty skin caused by the increased summertime room temperature and humidity.
Manufacturing and Fracture Behavior of Large Scale Multilayered Metal-Ceramic Nanocomposites
Authors: Young Austin T. , Farias Stephen L. , Hemker Kevin J. , Cammarata Robert C. 
Published: May 2014

ABSTRACTUniform and multilayered nanocomposites are of growing interest due to their desirable mechanical properties and their performance under high stress, wear, and impact conditions. Composite structures offer an opportunity to combine the useful properties from multiple materials. Controlled variations in composition and microstructure within a composite material allow for tunable local variations in properties. The simplest version of such a variation is to periodically change the composite volume fraction to create a multilayered composite material. Such structures would have hard layers to maintain strength and softer layers to allow for greater plasticity and prevent brittle failure. We are able to manufacture uniform and layered composites of nickel matrices embedded with alumina nanoparticles using electrodeposition. In this method a rotating disk electrode (RDE) is used to directly control the rate of particle incorporation. Uniform composites are made by holding a constant RDE rotation rate while layered composites are manufactured by periodically varying the rotation rate during deposition. We have demonstrated this novel manufacturing process for large-scale samples, several square centimeters in area and hundreds of microns thick, while maintaining submicron microstructural resolution.
Fatigue Crack Growth on Heterogeneous Stress Fields: Best Analytical Approach
Authors: Martin-Meizoso Antonio , Martinez-Esnaola Jose M. , Bergara Asier , Falconer Shaun 
Published: May 2014

ABSTRACTA way of estimating Stress Intensity Factors is proposed by extending available solutions (solid and crack configurations) to stress fields not considered in available formulations. The accuracy of the proposed estimation is considered with respect to fatigue life assessment and crack shape tracing. It is aimed as very fast initial estimation, in comparison with the use of Finite Elements, in those cases were a high stress gradient is observed: stress concentrations (holes, notches, grooves) or due to surface residual stresses produced by machining techniques or induced –on purpose- to improve fatigue life (for example, by shot-peening), where no SIF solutions are available.
On Fatigue Behavior of Cold Spray Coating
Authors: Moridi A. , Hassani-Gangaraj S. M. , Guagliano M. 
Published: May 2014

ABSTRACTCold spray is a novel and promising technology to obtain surface coating. Notwithstanding the several technological advantages with respect to other processes, its diffusion is somewhat limited because of the limited knowledge on the mechanical properties of the cold sprayed materials and in particular, the fatigue behavior. Moreover, the existing data concerning fatigue behavior of coated specimens are controversial and different material system shows different behaviors. The aim of this study is to distinguish the involved parameters and their effect on fatigue behavior of cold sprayed systems. A critical discussion on four important parameters i.e. interface quality, material properties, deposition parameters and residual stress is given. The influential parameters are consolidated in one formula, which can predict the fatigue limit of cold spray system as a function of residual stress, coating hardness and stress gradient in the specimen.
When Particles Meet Nanoindentation: A Novel Strategy for Studying Particle Motion and Particle/Surface Interaction
Authors: Fuchs Regina , Weinhart Thomas , Meyer Jan , Zhuang Hao , Staedler Thorsten , Jiang Xin , Luding Stefan 
Published: May 2014

ABSTRACTA plethora of applications in pharmacy, cosmetics, food industry and other areas are directly linked to the research fields of particle technology and contact mechanics. Here, a typical particle ensemble features particle sizes ranging from the nanometer up to the micrometer regime. In this context we introduce a nanoindentation based approach capable of probing mechanical interaction of micron-sized particles. Basically, the concept of the colloid probe technique, which is well established in the AFM community, is transferred to a nanoindenter. In particular, this setup allows addressing limitations, which are typically associated with AFM based techniques, such as particle weight and accessible load regime. Additionally, we will show the versatility of this approach by presenting simple experimental paths capable of probing sliding, rolling and torsional friction. The potential of such setting is shown by studying rolling friction of silica microspheres featuring radii of about 2.5µm, 10µm, 25 and 50µm in contact with various substrates, respectively. Substrates utilized within the framework of this study are Si surfaces featuring various roughness as well as flat gold films (300nm film thickness). Key aspects of this work include the influence of surface roughness, adhesion force, humidity and the elastic/plastic transition on the rolling contact of the corresponding particles.
Surgical Management of a Recurrent Peripheral Ossifying Fibroma
Authors: Horwitz Jacob , Akrish Sharon Jill , Abu El‐Naaj Imad 
Published: May 2014

Introduction: Peripheral ossifying fibromas (POFs) are locally reactive gingival lesions originating from the superficial periodontal ligament that are found most often in the anterior maxilla with a relatively high recurrence rate.Case Presentation: This case report describes the surgical management of a recurrent POF and the reconstruction modality of the gingival defect by the use of a free gingival graft after excision of the lesion. Excisional biopsy was performed by debriding the underlying bone and tooth and covering the residual defect with a free gingival graft harvested from the hard palate.Conclusion: A large gingival defect attributable to a reactive lesion pathology such as a POF can be reconstructed successfully with a free gingival graft with predictable results.
Longitudinal Comparison of Cytokines in Peri‐Implant Fluid and Gingival Crevicular Fluid in Healthy Mouths
Authors: Nogueira‐Filho Getulio , Pesun Igor , Isaak‐Ploegman Cindy , Wijegunasinghe Manjula , Wierzbicki Tom , McCulloch Christopher A. 
Published: May 2014

Background: Peri‐implant and gingival tissues provide important sealing and protective functions around implants and teeth, but comparisons of the immunologic responses of these tissues after implant placement have not been conducted. Cytokine levels were measured in peri‐implant crevicular fluid (PICF) and gingival crevicular fluid (GCF) as surrogate measures of immune function at subcrestally placed dental implants and healthy periodontal sites during a 1‐year monitoring period.Methods: A total of 27 dental implants were placed subcrestally in 21 periodontally healthy patients (mean age: 49.0 ± 13.4 years). Repeated clinical and cytokine measurements were obtained over 12 months. GCF and PICF samples were collected and analyzed by cytokine microarray. Data were examined by non‐parametric analysis of variance.Results: Plaque and bleeding indices were similar among all patients (P >0.05) at baseline. During 1 year of monitoring, the mean volumes of PICF and GCF were similar (P >0.05). The levels of interleukin (IL)‐4, ‐6, ‐10, and ‐12p70, tumor necrosis factor‐α, and interferon‐γ in GCF and PICF were not significantly different and did not vary over time (P >0.05). The levels of IL‐1α were higher in GCF than PICF at 1, 2, 6, and 12 months, as were the levels of IL‐8 at 1, 2, 4, 6, and 12 months (P <0.001). Transforming growth factor‐β1 in PICF and GCF exhibited time‐dependent increases, and vascular endothelial growth factor was reduced at 1 year without differences between PICF and GCF (P >0.05).Conclusion: Within the limitations of this study design, it can be concluded that after subcrestal implant placement, the immune response of peri‐implant and periodontal tissues, as assessed by cytokine levels in PICF and GCF, is similar.
Epidemiology and Antimicrobial Resistance of International Travel-Associated Campylobacter Infections in the United States, 2005–2011
Authors: Ricotta Emily E. , Palmer Amanda , Wymore Katie , Clogher Paula , Oosmanally Nadine , Robinson Trisha , Lathrop Sarah , Karr Jillian , Hatch Julie , Dunn John , Ryan Patricia , Blythe David 
Published: May 2014

Objectives. The objective of this study was to determine the role international travel plays in US Campylobacter epidemiology and antimicrobial resistance. Methods. In this study, epidemiological and antimicrobial resistance data, encompassing the years 2005 to 2011, from 10 sites participating in the Foodborne Diseases Active Surveillance Network were linked. The 10 sites are represented by 7 states that conducted surveillance on a statewide level, and 3 states which conducted county-level surveillance. Cases of Campylobacter among persons with history of international travel in the week prior to illness were compared with cases among individuals with no international travel. Results. Approximately 18% of Campylobacter infections were estimated to be associated with international travel, and 60% of international travel-associated infections had a quinolone-resistant Campylobacter isolate. Conclusions. We confirm that international travel plays a significant role in campylobacteriosis diagnosed in the United States. Recognizing this is important to both medical management decisions and understanding burden and attribution estimates of US campylobacteriosis and antibiotic-resistant campylobacteriosis.
A Novel System Dynamics Model of Female Obesity and Fertility
Authors: Sabounchi Nasim S. , Hovmand Peter S. , Osgood Nathaniel D. , Dyck Roland F. , Jungheim Emily S. 
Published: May 2014

Objectives. Our objective was to create a system dynamics model specific to weight gain and obesity in women of reproductive age that could inform future health policies and have the potential for use in preconception interventions targeting obese women. Methods. We used our system dynamics model of obesity in women to test various strategies for family building, including ovulation induction versus weight loss to improve ovulation. Outcomes included relative fecundability, postpartum body mass index, and mortality. Results. Our system dynamics model demonstrated that obese women who become pregnant exhibit increasing obesity levels over time with elevated morbidity and mortality. Alternatively, obese women who lose weight prior to pregnancy have improved reproductive outcomes but may risk an age-related decline in fertility, which can affect overall family size. Conclusions. Our model highlights important public health issues regarding obesity in women of reproductive age. The model may be useful in preconception counseling of obese women who are attempting to balance the competing risks associated with age-related declines in fertility and clinically meaningful weight loss.
Health Literacy: A Pathway to Better Oral Health
Authors: Guo Yi , Logan Henrietta L. , Dodd Virginia J. , Muller Keith E. , Marks John G. , Riley Joseph L. 
Published: May 2014

Objectives. We examined whether health literacy was associated with self-rated oral health status and whether the relationship was mediated by patient–dentist communication and dental care patterns. Methods. We tested a path model with data collected from 2 waves of telephone surveys (baseline, 2009–2010; follow-up, 2011) of individuals residing in 36 rural census tracts in northern Florida (final sample size n = 1799). Results. Higher levels of health literacy were associated with better self-rated oral health status (B = 0.091; P < .001). In addition, higher levels of health literacy were associated with better patient–dentist communication, which in turn corresponded with patterns of regular dental care and better self-rated oral health (B = 0.003; P = .01). Conclusions. Our study showed that, beyond the often-reported effects of gender, race, education, financial status, and access to dental care, it is also important to consider the influence of health literacy and quality of patient–dentist communication on oral health status. Improved patient–dentist communication is needed as an initial step in improving the population’s oral health.
Control Systems Engineering for Optimizing a Prenatal Weight Gain Intervention to Regulate Infant Birth Weight
Authors: Savage Jennifer S. , Downs Danielle Symons , Dong Yuwen , Rivera Daniel E. 
Published: May 2014

Objectives. We used dynamical systems modeling to describe how a prenatal behavioral intervention that adapts to the needs of each pregnant woman may help manage gestational weight gain and alter the obesogenic intrauterine environment to regulate infant birth weight. Methods. This approach relies on integrating mechanistic energy balance, theory of planned behavior, and self-regulation models to describe how internal processes can be impacted by intervention dosages, and reinforce positive outcomes (e.g., healthy eating and physical activity) to moderate gestational weight gain and affect birth weight. Results. A simulated hypothetical case study from MATLAB with Simulink showed how, in response to our adaptive intervention, self-regulation helps adjust perceived behavioral control. This, in turn, changes the woman’s intention and behavior with respect to healthy eating and physical activity during pregnancy, affecting gestational weight gain and infant birth weight. Conclusions. This article demonstrates the potential for real-world applications of an adaptive intervention to manage gestational weight gain and moderate infant birth weight. This model could be expanded to examine the long-term sustainable impacts of an intervention that varies according to the participant’s needs on maternal postpartum weight retention and child postnatal eating behavior.