bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early economic evaluation of chelation therapy in kidney transplant recipients with high-normal lead
Authors: Hao Jiasi , Alizadeh Behrooz Z. , Postma Maarten J. , Touw Daan J. , Bakker Stephan J. L. , de Jong Lisa A. 
Published: February 2025

Background
Kidney transplant recipients (KTR) with high-normal lead have a higher risk of graft failure (GF). Clinically, chelation therapy using meso-2,3-dimercaptosuccinic acid (DMSA) removes lead. Despite the proposal that chelation therapy can prevent GF through lead removal, evidence is lacking. To guide research efforts, we conducted an early economic evaluation, aiming to explore the economic feasibility of screening for and implementing chelation therapy with oral DMSA for high-normal plasma lead concentrations in KTR (i.e., the intervention) compared to standard of care.

Methods
A Markov model simulated the life course of 10,000 KTR in the Netherlands from a societal perspective. Transition probabilities were estimated using the data from TransplantLines Food and Nutrition Biobank and Cohort study. Costs and utilities were sourced from publications and public data. Model robustness was investigated through deterministic and probabilistic sensitivity analyses. Various administration strategies were tested. Five-year costs were calculated from a healthcare payer’s perspective. Value of information was assessed.

Results
The intervention was cost-saving and improved health, leading to a dominant incremental cost-effectiveness ratio. The result was most sensitive to transition probabilities (led by GF, followed by death with functioning graft and after graft failure). The probability of the intervention being cost-effective was 60%. Chelation strategies did not affect the result. The intervention applied to the Dutch KTR population could save €27 million in the initial five years. Further research is desirable if the cost of obtaining perfect information on GF survival is approximately below €4,000/KTR (all uncertainties under €5,000/KTR).

Conclusion
The cost-effectiveness of the intervention is robust in KTR, except when considering the uncertainties around (graft) survival probabilities. Applying chelation therapy in the new setting we studied holds significant potential. However, trials that systematically assess the efficacy, administration strategies, and impacts on survival are crucial in updating the current evaluation and informing policies.
Finding your own voice
Authors: Hajian George , Powley Caroline 
Published: February 2025

E koekoe te tūī, e ketekete te kākā, e kūkū te kererū.
(The tūī chatters, the kākā cackles, the kererū coos.)
The appeal of printed matter extends beyond the visual to include the ability to convey voice and emotion. Much like ‘vocal inflexion’ in spoken language, type and typography imbue content with a unique tone or ‘voice’. Using the above Māori whakataukī (‘proverb’) as a metaphor to investigate typographic voice, we devised a new twelve-week course which invites students to create a multi-sectional publication responding to endemic birds. Birds are symbolic creatures in Māori mythology and hold a special place in te ao Māori (world-view). As tauiwi kaiako (‘non-Māori teachers’) entrusted with the responsibility to design resources that honour an Indigenous partnership under Te Tiriti o Waitangi, the whakataukī acts as a catalyst to develop an inclusive curriculum. The syllabus for this introductory article is pedagogically structured to scaffold students’ learning. Built as a sequence of analogue and digital exercises, students are encouraged to explore distinct compositional strategies relevant to six diverse types of content: (1) creating dynamic text forms to reflect poetry, (2) generating typographic patterns with letterforms to represent birdsong, (3) integrating letterforms with images to create expressive descriptions, (4) using hierarchy to establish structure within long-form text, (5) using expressive text to depict symbolism and significance in culture and (6) composing fluid lines of text to express rhythm within a song. The resulting multi-sectional publications also reflect the whakataukī by bringing together distinctive print and typographic formats into a cohesive publication – a collective ‘chorus’ of different typographic voices. This article unpacks examples of student work to elucidate learning and successes, highlighting practical challenges of teaching diverse students and introducing them to a conceptual framework for a communication design project through the metaphor of ‘voice’.
Quality of Life in the Hetmanate and Left-Bank Ukraine in the 18th–19th Centuries: Between ‘Subjective’ Narratives and ‘Objective’ Markers
Authors: Serdiuk Igor 
Published: February 2025

Abstract
This article aims to better understand the quality of life in Left-bank Ukraine during the 18th and 19th centuries through the analysis of a wide range of social, economic, and demographic indicators. The concept of ‘quality of life’ is considered as an interdisciplinary framework combining sociological, economic, historical, and demographic approaches. The study also evaluates the potential of various sources, including diaries, chronicles, statistics, and population censuses. Particular attention is paid to the subjective perception of well-being and its treatment in historical sources. The research demonstrates that quality of life in the region was closely connected with access to resources, education levels, infrastructure development, and professional medicine. A significant aspect of the study is the exploration of differences in perceptions of well-being among various authors. For instance, foreign travelers often romanticized or, conversely, criticized the everyday life of Left-bank Ukraine, depending on their personal views and experiences. The article analyzes key spheres affecting quality of life, such as social inequalities, population density, agrarian culture, and urbanization levels. The author emphasizes that quality of life did not always improve alongside modernization, and the expansion of urban infrastructure, for example, often adversely affected living conditions for certain groups as a consequence of inadequate water supply and sewage systems. The study highlights the necessity of analyzing historical transformations through the integration of subjective and objective data. The conclusions suggest that to objectively assess the quality of life in the region, researchers need measurable and comparable markers, as well as integral indicators reflecting the impact of various factors on human lives. Mortality rates and life expectancy are proposed as such indicators. Existing data for Left-bank Ukraine indicate a noticeably higher quality of life in the region compared to the provinces of European Russia at that time. However, this data is insufficient, referring only to the quality of life in Left-bank Ukraine at its ‘exit point’ from its ‘exit point’ from its situation of subjugation to empire. Without knowledge of mortality and life expectancy at its ‘entry point’, when the Hetmanate was still a distinct social and economic entity, such data can be interpreted in various contradictory ways, as is happening now. Therefore, the next stage of research would require studying these same indicators as they apply to the Hetmanate.
Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer
Authors: Goyal Kavita , Babu M. Arockia , Afzal Muhammad , Rekha Arcot , Ali Haider , Gupta Saurabh , Singh Ravindra Pal , Mishra Anurag , Singh Himmat , Agrawal Mohit , Rana Mohit , Imran Mohd , Khan Abida 
Published: February 2025

Abstract
Fisetin, a flavonol belonging to the flavonoid subclass, is a ubiquitous dietary flavonoid present in fruits and vegetables, including fruit peels, and has proven potential for anticancer activity, especially for lung cancer – a leading cause of cancer-related deaths globally. The current paper provides the most detailed and elaborate list of the various roles of fisetin in experimentally induced lung cancer cells, and these roles include the promotion of apoptosis, inhibition of cell proliferation, migration, and invasion, as well as the regulation of autophagy. Among the molecular targets, some identified pathways, such as PI3K/Akt, MAPK, and NF-κB, that fisetin affects are crucial for tumor formation, so it can be considered a potential chemopreventive agent. Moreover, fisetin improves the effectiveness of conventional treatments as a chemo- and radiosensitizer and minimizes side effects. However, the overall utility of fisetin for clinical use is now somewhat restricted by its poor solubility and short half-life. It is predicted that the future development of nanotechnologies for drug delivery, such as nanoparticle encapsulation, might help solve these difficulties. Further Preclinical and clinical investigations are required to uniformly determine the safety, efficacy, and standard dosage of fisetin for consumption in lung cancer therapy.
Hybrid modeling of structure extension and instance weighting for naive Bayes
Authors: Yu Liangjun , Wang Di , Zhou Xian , Wu Xiaomin 
Published: February 2025

Abstract
Due to robustness and efficiency, naive Bayes (NB) remains among the top ten data mining algorithms. However, the required conditional independence assumption more or less limits its classification performance. Of numerous approaches to improving NB, structure extension and instance weighting have both achieved remarkable improvements. To make full use of their complementary and consensus advantages, this article proposes a hybrid modeling approach to combining structure extension with instance weighting. We call the resulting model instance weighted averaged one-dependence estimators (IWAODE). In IWAODE, the dependencies among attributes are modeled by an ensemble of one-dependence estimators, and the corresponding probabilities are estimated from attribute value frequency-weighted training instances. The classification performance of IWAODE is experimentally validated on a large number of datasets.
Thermodynamic characterization of transient valve temperatures in diesel engines using probabilistic methods
Authors: Kumar Pardeep , Gupta Anikate , Kumar Dinesh , Sharma Vipin Kumar , Rai Santosh Kumar 
Published: February 2025

Abstract
This investigation aimed to predict the temperature distribution in the inlet and exhaust valve and isotherms to the cooling media at a given load of a diesel engine. For the analysis that has been done a Tata- Mercedes diesel engine with 90 mm bore diameter and Stroke length of 120 mm was analysed using FEM through Ansys workbench 15.0. Steady as well as transient cases were considered in combination. The temperature distribution and isotherms are computed and plotted using Ansys. The results obtained by Ansys workbench 15.0 were satisfactory and were in line when compared with finite differential analysis. There is a large temperature variation along the length of the valve. It may vary from 560 °C to 110 °C from tip to valve head in the exhaust valve while this variation is less in the case of inlet valve from 540 °C to 100 °C from the face to the tip. The linear temperature difference between the nodes at the base of the stem to the node at the center of the face increases with time and acquires the maximum value of about 120 °C at about 10 s then it decreases till the valve attains a steady state value. Thus, was observed from analysis that during this time there is a maximum probability of failure of valves due to linear differences in temperature.
Crystal structure of catena-poly[(μ
3-4,4′-oxydibenzoato- κ
5
O,O
′: O
″,O
‴:O
‴)-bis(2,4,6-tri(3-pyridine)-1,3,5-triazine-κ
1
N)cadmium(II)], C50H32CdN12O5
Authors: Jing Hao , Ke Liu , Xia Hou , Hai Wang 
Published: February 2025

Abstract
C50H32CdN12O5, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 9.0273(2) Å, b = 15.4626(3) Å, c = 15.8910(2) Å, α = 96.5060(10)°, β = 98.5010(10)°, γ = 97.354(2)°, V = 2155.88(7) Å3, Z = 2, R

gt
(F) = 0.0320, wR

ref
(F
2) = 0.0849, T = 100 K.
Klimaschutz durch Degrowth? – Ordonomische Anfragen an die Position radikaler Wachstumskrititk
Authors: Pies Ingo , Schultz Felix Carl 
Published: February 2025

Kurzfassung
Der Weltklimarat (IPCC) hat jüngst eine Autorengruppe wohlwollend rezipiert, die die These vertritt, Klimaschutz könne (nur) durch Wachstumsverzicht – durch Nullwachstum und besser noch durch Negativwachstum – ambitioniert vorangetrieben werden. Wir rekonstruieren diese spezifische Degrowth-Argumentation und konfrontieren sie aus der Perspektive des ordonomischen Forschungsprogramms mit zwei kritischen Anfragen. Im Ergebnis sehen wir uns veranlasst, die im Titel aufgeworfene Frage zu verneinen. Unsere Gegenargumente lauten: (a) Degrowth verkennt die zivilisatorischen Vorzüge der post-malthusianischen Wachstumsgesellschaft. (b) Degrowth nimmt die klimapolitische Herausforderung nicht ernst genug. Insbesondere wird unterschätzt, dass die zum Klimaschutz für nötig gehaltenen Innovationen unternehmerischer Anstrengungen bedürfen und insofern marktwirtschaftliche Leistungsanreize voraussetzen.
Spontaneous dehydration side reactions of core amino acids in GC-MS sample preparation: the role of drying conditions
Authors: Karnaeva Anastasia E. , Korzhenevskii Dmitry A. , Nesterenko Alexey M. 
Published: February 2025

Abstract
The metabolomic and metabolic flux analyses often require accurate measurement of amino acids, which can be effectively conducted using GC-MS analysis after preliminarily trimethylsilyl (TMS) derivatization. Among the four central amino acids (glutamate, alanine, serine and aspartate) taken for the study, glutamate has the most peculiar behaviour because of pyroglutamic acid formation. We have discovered that spontaneous non-enzymatic cyclisation occurs only if we dry glutamate from aqueous solution before starting TMS derivatization in pyridine. We investigated various factors during sample preparation and injection into the GC that could affect glutamate cyclisation, and the decisive factor was the presence of water in the sample, which could catalyse the glutamate cyclization process. Very important practical advice was demonstrated that drying from a water-methanol solution (1:1, v/v) instead of drying from water solution significantly prevents the formation of pyroglutamate. Brief research of three other amino-acids indicate the similar problems for alanine and serine amino acids: formations of anhydrides likely happened during drying from pure water solutions.
Elucidating the effect of CdO–Na2O exchange on structure, mechanical and radiation shielding improvements of B2O3–P2O5–Na2O glass
Authors: Shaaban Kh. S. , Al-Baradi Ateyyah M. , Aloraini Dalal Abdullah 
Published: February 2025

Abstract
This study examined the elastic, and radiation resistance of CdO–B2O3–P2O5– Na2O glasses. The density observed increased from 3.42 to 4.87 g/cm3 in conjunction with the increase in CdO content. As the CdO increases, the (V

L
) increases from 4,690 to 5,040 m/s. Similarly, the (V

S
) increases from 2,045 to 2,275 m/s. Furthermore, the elastic moduli showed a linear increase with the increment of CdO concentration. The evaluation of multiple basic radiation attenuation variables was used to determine the radiation shielding of these glasses. This indicates that the addition of CdO has a positive influence on the glass’s ability to attenuate γ radiation. This suggests that this specific glass composition is effective in attenuating γ, making it appropriate for radiation shielding purposes.
The effect of peer group management intervention on chronic pain intensity, number of areas of pain, and pain self-efficacy
Authors: Reilimo Marjatta Inkeri , Sainio Markku , Liira Juha , Laurola Marjukka 
Published: February 2025

Abstract

Objectives
Chronic pain causes loss of workability, and pharmacological treatment is often not sufficient, whereas psychosocial treatments may relieve continual pain. This study aimed to investigate the effect of peer group management intervention among patients with chronic pain.

Methods
The participants were 18–65-year-old employees of the Municipality of Helsinki (women 83%) who visited an occupational health care physician, nurse, psychologist, or physiotherapist for chronic pain lasting at least 3 months. An additional inclusion criterion was an elevated risk of work disability. Our study was a stepped wedge cluster, randomized controlled trial, and group interventions used mindfulness, relaxation, cognitive behavioral therapy, and acceptance and commitment therapy. We randomized sixty participants to either a pain management group intervention or to a waiting list with the same intervention 5 months later. After dropouts, 48 employees participated in 6 weekly group meetings. We followed up participants from groups A, B, and C for 12 months and groups D, E, and F for 6 months. As outcome measures, we used the pain Self-Efficacy Questionnaire, the number of areas of pain, the visual analog scale of pain, and the pain self-efficacy. We adjusted the results before and after the intervention for panel data, clustering effect, and time interval.

Results
The peer group intervention decreased the number of areas of pain by 40%, from 5.96 (1–10) to 3.58 (p < 0.001), and increased the pain self-efficacy by 15%, from 30.4 to 37.5 (p < 0.001). Pain intensity decreased slightly, but not statistically significantly, from 7.1 to 6.8.

Conclusions
Peer group intervention for 6 weeks among municipal employees with chronic pain is partially effective. The number of areas of pain and pain self-efficacy were more sensitive indicators of change than the pain intensity. Any primary care unit with sufficient resources may implement the intervention.
MLST Evidence of Two Different Sequence Types of Listeria Monocytogenes Strains Used for Commercial Veterinary Listeriosis Vaccines
Authors: Kichemazova Natalya , Zaytsev Sergey , Saltykov Yury , Larionova Olga , Zaberezhny Alexey , Feodorova Valentina 
Published: February 2025

Objective:
Listeriosis is among the most severe food-borne diseases affecting both animals and humans, and it presents a serious threat to public health, animal welfare, and the food industry. Food products contaminated with Listeria monocytogenes (Lm), the causative agent of listeriosis, are recognized as the primary source of infection. Since the late 1960s, the live whole-cell vaccine AUF (LWCV AUF) has been successfully used for the prevention of listeriosis in farm animals in Russian regions affected by the disease. This commercial vaccine is based on manufactured batches of the two ovine parental Lm strains isolated in various regions of the former USSR, Siberia, and Azerbaijan, from distinct animals in different years. This study was aimed at investigating whether these strains might belong to the same phylogenetic lineage and possess identical sequence types (STs).

Methods:
One Lm vaccine strain was attenuated by multiple ultraviolet irradiation (UFR), whereas the other was obtained through routine techniques involving multiple passages on bacteriological media. Multilocus sequence typing (MLST) analysis was performed with amplification and sequencing of internal fragments of seven housekeeping genes (abcZ, bglA, cat, dapE, dat, ldh, and lhkA). For morphological comparison, both Lm strains were grown on Chromocult Listeria Agar Ottaviani and Agosti bacterial media.

Results:
Both attenuated Lm strains belonged to a single phylogenetic lineage (lineage II), and were assigned to different STs (ST124 and ST1538), and clonal complexes (CCs), (CC124 and CC7). In addition, these strains demonstrated different morphological characteristics when grown on bacterial media standard for Lm.

Conclusion:
The LWCV AUF is formulated on two manufactured attenuated Lm strains belonging to two genetically different lineages.
Post-mortem interval leads to loss of disease-specific signatures in brain tissue
Authors: Olney Kimberly C. , Gibson Katelin A. , Cadiz Mika P. , Rahimzadeh Negin , Swarup Vivek , Fryer John D. 
Published: February 2025

Human brain banks are essential for studying a wide variety of neurological and neurodegenerative diseases, yet the variability in post-mortem interval (PMI)—the time from death to tissue preservation—poses significant challenges due to rapid cellular decomposition, protein alterations, and RNA degradation. Furthermore, the post-mortem transcriptomic alterations occurring within distinct cell types are poorly understood. In this study, we analyzed the effect of a 3-hour post-mortem interval on single-nucleus RNA signatures in the brains of wild-type (WT) and PS19 mice, a common model of tauopathy. We observed that basic quality control metrics (such as the number of genes and reads per cell), total nuclei counts, and RNA integrity number (RINe) remained consistent across all samples, regardless of PMI or genotype. However, a 3-hour PMI diminished the number of genes differentially expressed between PS19 and WT mice, suggesting an impact of delayed processing on the detection of disease-specific transcriptomic signatures. When directly comparing 3-hour PMI versus freshly harvested 0-hour mouse brains, we identified genes upregulated in neurons and interneurons involved in DNA repair, immune response, and stress pathways. Furthermore, genes that were altered in non-neuronal cell types at 3-hours versus 0-hour PMI were associated with cell-cell adhesion processes. These findings highlight the effects of PMI on single-nucleus transcriptional changes that may dampen the true changes in cellular states in banked brain tissues.Significance StatementThis study investigates how post-mortem interval (PMI)—the time between death and tissue preservation—affects gene expression in brain cell types using single-nucleus RNA sequencing. By comparing brain samples collected immediately and 3 hours post-mortem in mice, we found that PMI can obscure disease-related gene expression changes, especially in neurons. These findings underscore the importance of accounting for PMI in studies of neurodegenerative disease using human brain banks.