bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical advances in the determinations of dietary sphingolipids in milk, dairy products, and infant formula and impacts on human health
Authors: Karrar Emad , Usman Muhammad , Mohamed Ahmed Isam A. , Brennan Charles S. , Xu Minwei , Jin Zhao 
Published: August 2024

SummarySphingolipids (SL) are bioactive compounds in milk, dairy products, and infant formula. SL has been found to have different health benefits, such as anti‐inflammatory, antimicrobial, anticancer, and cholesterol‐lowering characteristics. SL requires careful extraction, separation, and identification due to their unique characteristics. This review discusses the importance of extracting, purifying, and analysing SL from milk and dairy products. OE (Organic extraction), SPE (solid‐phase extraction), and SFE (supercritical CO2) techniques, as well as dispersive OE and SPE, are the most common methods. In addition, this review discussed various analytical techniques that can be used to determine and quantify SL classes, including TLC (thin‐layer chromatography), HPLC (high‐performance liquid chromatography), nuclear magnetic resonance spectroscopy, and mass spectrometry. These techniques are crucial for understanding the amounts of SL dairy products and infant formula. The paper also focuses on the different types of SL present in milk, dairy products, and infant formula and their concentrations. SL has the potential to be applied to the development of functional foods, and further research in this area is needed. This article sheds light on the extract, purification, and analysis of SL dairy products and infant formula, as well as their potential health benefits.
The effect of Orem's Self‐Care Deficit Theory–based care during pregnancy and postpartum period on health outcomes: A systematic review and meta‐analysis
Authors: Tümkaya Maide Nur , Eroğlu Kafiye , Karaçam Zekiye 
Published: August 2024

AbstractAimTo examine the effect of the provision of care on health outcomes when provided based on Orem's Self‐Care Deficit Theory during perinatal period.BackgroundThe perinatal period is a process with multidimensional care needs for the mother, baby and family. Care based on nursing theories can improve the quality of perinatal care.DesignA systematic review and meta‐analysis.Review methodsStudies on this topic from 2006 to 2020 have been accessed by nine database searches. The methodological quality of the studies was assessed using the Critical Appraisal Checklists for experimental and quasi‐experimental studies, developed by the Joanna Briggs Institute. This study was conducted by following the Preferred Reporting System for Systematic Reviews and Meta‐Analyses.ResultsThis systematic review included nine studies with a total sample size of 839 women. These studies showed that care based on Orem's theory significantly helped prolong the mean duration of pregnancy, reduced the incidence of preterm labor, improved hygiene behaviour and increased empowerment. Concerning the perinatal period, this intervention significantly improved self‐care and readiness for hospital discharge, adaptation and breastfeeding self‐efficacy and reduced nipple pain and pain due to abdominal distension.ConclusionsThe implementation of this theory into care during the perinatal period can contribute to improved health outcomes.Summary statementWhat is already known about this topic?

The quality of pregnancy and postpartum care is important for the maternal health.
The use of nursing theories—which nursing knowledge is produced—improves care quality and ensures that care is organized systematically.
What this paper adds?

There is insufficient research that supports Orem's theory of self‐care deficit in pregnancy and postpartum care and also no systematic review about this topic, but the current meta‐analysis showed that postnatal and prenatal treatments based on Orem's theory have a positive impact on the self‐care agency.
The implications of this paper:

The use of Orem's theory helps nurses understand women and their needs during pregnancy and postpartum periods.
Integrating Orem's theory of self‐care deficit into pregnancy and postpartum nursing care services can help increase women's self‐care power.
The Australian Team Approach to Polypharmacy Evaluation and Reduction (AusTAPER) hospital study: effect of a collaborative medication review on the number of current regular medicines for older hospital inpatients
Authors: Etherton‐Beer Christopher , Page Amy , Criddle Deirdre , Somers George , Parkinson Lynne , Clifford Rhonda , Mangin Dee 
Published: August 2024

AbstractBackground and AimsPotentially harmful polypharmacy is a growing public health concern. This article aims to evaluate the effectiveness of a structured Team Approach to Polypharmacy Evaluation and Reduction (AusTAPER) framework.MethodsWe recruited patients at metropolitan hospitals for a randomised controlled trial with 12 months of follow‐up. The intervention included a comprehensive medicines history, multidisciplinary meeting and medicines review prior to discharge, with engagement with the participants' general practitioner extending after discharge. The primary outcome was the change in the number of regular medicines used at 12 months from baseline. A cost consequence was performed to estimate costs per participant during the study period.ResultsThere were 98 participants enrolled in the study. The number of regular medicines was significantly reduced from baseline in both groups (−1.7 ± 4.3, t = 2.38, P = 0.02 in the control group vs −2.7 ± 3.6, t = 4.48, P = 0.0001 in the intervention group), although there was no statistical difference detected between the two groups (1.0 (SE 0.9), t = 1.03, P = 0.31). The intervention was estimated to cost AU$644.17 and was associated with cost savings of AU$552.53 per participant in sustained reduced medicines cost. Health outcomes and healthcare costs were similar in both groups.DiscussionMedicines were significantly reduced in both groups, with a trend to a larger reduction in medicines at 12 months in the intervention group. The intervention cost was approximately offset by sustained reduced medicines cost, although these results should be regarded cautiously because of the absence of significance in the differences in outcomes between groups.
Influence of cerium addition and redox state on silicate structure and viscosity
Authors: Donatini Adrien , Pereira Luiz , Dingwell Donald B. , Hess Kai‐Uwe , Müller Dirk , Cormier Laurent , Neuville Daniel R. 
Published: August 2024

AbstractThe viscosities of Ce‐free and Ce‐bearing (∼1.3 mol%, ∼6.5 wt.% Ce2O3) soda lime silicate (window glass) melts were measured with respect to oxidation state. Experiments were performed isothermally using a concentric‐cylinder viscometer on melts equilibrated with successively reducing CO–CO2 gas mixtures within a gas tight vertical tube furnace at 1 atm. Viscosity measurement and sampling were performed at the end of each melt reduction step. Further, viscosities in the glass transition temperature range were estimated using the shift factor method applied to glass transition temperature values determined using differential scanning calorimetry (DSC) measurements on quenched glasses. The Ce speciation at each stepwise melt reduction was probed using Ce L3‐edge X‐ray absorption near‐edge structure (XANES) spectroscopy, while structural information upon Ce addition and reduction was provided by Raman spectroscopy. The viscosities of these materials remain constant at this level of Ce addition and do not vary significantly with redox state at high temperature. Conversely, viscosity values in the glass transition temperature range increase upon both Ce addition and reduction. Our analysis, based on the glass composition analyses obtained via electron probe microanalyzer (EPMA), viscosity calculations, and observations of silicate structural changes, leads to the conclusion that the observed viscosity increase around the glass transition temperature is explained by the high ionic field strength of Ce ions as well as the polymerization behavior of the silicate matrix occurring during reduction of Ce. Because of its low concentration, resulting from its low solubility, Ce redox changes exert only minimal effects on the viscosity of this melt.
Social‐ecological barriers and facilitators to seeking inpatient psychiatric care among transgender and nonbinary people: A qualitative descriptive study
Authors: Boutilier Ava J. , Clark Kristen D. , Bosse Jordon D. , Jackman Kasey B. , Jewell Jaylyn , Dawson‐Rose Carol 
Published: August 2024

AbstractAim(s)To assess barriers and facilitators to seeking inpatient psychiatric treatment among transgender and nonbinary people.DesignQualitative interview study.MethodsSemi‐structured interviews were conducted from March 2019 to June 2022 with transgender and nonbinary people admitted to an inpatient psychiatric hospital in the United States during the past 5 years. Data were analysed using thematic analysis and constructed within a modified social‐ecological model of stigma. Standards for Reporting Qualitative Research were used for this study.ResultsParticipants (N = 15) described barriers and facilitators across all three social‐ecological levels. i) Individual themes included distrust of the mental healthcare system, feeling unsafe, loss of autonomy, minimizing one's own mental health needs, and feelings of accountability to others. ii) Interpersonal themes included: lack of support for transgender/nonbinary identity, limited transgender/nonbinary knowledge among mental healthcare professionals, and allyship. iii) Structural themes included: carceral setting, financial costs, and availability of non‐profit treatment options.ConclusionMulti‐level themes were identified as barriers and facilitators to seeking inpatient psychiatric care for transgender and nonbinary people, providing opportunities among inpatient settings to improve care delivery and engagement. Greater health equity can be achieved by addressing barriers to care.ImplicationsIncorporating inclusive and affirming practices in inpatient psychiatric services presents an opportunity to reduce barriers to seeking care.ImpactThe present study describes the experiences of transgender and nonbinary people as they determine whether to voluntarily seek inpatient psychiatric treatment. This perspective allows nurses, health systems, and policymakers to integrate transgender and nonbinary people's needs to improve healthcare delivery.Patient/Public ContributionTransgender and nonbinary participants were recruited in collaboration with community organizations. Members of the transgender and nonbinary community participated in study design development and analysis and were part of the study team.
Mediating Role of Evidence‐Based Nursing Competence Between Specialist Nurses' Information Literacy and Innovative Behaviour: A Multicentre Cross‐Sectional Study
Authors: Wang Zeen , Wen Na , Ren Yuanpeng , Liang Wei , Ding Yaping , Ji Minghui , Xu Min , Chen Chunyan , Song Yan , Chen Xian 
Published: August 2024

ABSTRACTAimTo investigate the levels of information literacy, evidence‐based nursing competence and innovative behaviour in specialist nurses, determine the impact of information literacy and evidence‐based nursing competence on the innovative behaviour of specialist nurses and to analyse the mediating role of evidence‐based nursing competence between information literacy and innovative behaviour among specialist nurses.DesignA multicenter cross‐sectional design.MethodsIn March 2024, a survey was conducted on 313 specialist nurses in four tertiary Grade A comprehensive hospitals in China. Data collection involved the utilization of general demographic questionnaire, the Information Literacy Questionnaire, the Evidence‐Based Nursing Competence Scale and the Nurse Innovation Behaviour Scale. The data were analysed using IBM SPSS26 and Amos28 software.ResultsSpecialist nurses scored above average in information literacy, evidence‐based nursing competence and innovative behaviour. Information literacy significantly positively correlated with innovative behaviour. Evidence‐based nursing competence also positively affected innovative behaviour and partially mediated the relationship between information literacy and innovative behaviour.ConclusionThis research indicated that specialist nurses exhibited above‐average levels of evidence‐based nursing competence, information literacy and innovative behaviour. Both information literacy and evidence‐based nursing competence positively impacted innovative behaviour, with evidence‐based nursing competence playing a significant mediating role between information literacy and innovative behaviour.ImpactThe findings suggest that nursing managers should focus on enhancing information literacy and evidence‐based nursing competence in specialist nurses. Improving these abilities will support the implementation of innovative practices and advance the nursing field.Reporting MethodThe research findings were presented in strict accordance with the STROBE statement.Patient or Public ContributionNot applicable.Contribute to the Wider Global Clinical CommunityIt provides reference guidance and theoretical basis for global nursing managers to formulate targeted interventions, so as to effectively enhance the innovative behaviour of specialist nurses.
Understanding capabilities, opportunities and motivations to engage in physical activity for adults with intellectual disabilities: A qualitative evidence synthesis
Authors: Westrop Sophie C. , Maenhout Laura , Melville Craig A. , McGarty Arlene M. 
Published: August 2024

AbstractBackgroundThere is a paucity of theory‐informed physical activity research with adults with intellectual disabilities. This study aimed to address this by synthesising existing literature and applying the COM‐B model to understand capabilities, opportunities and motivations.MethodsA qualitative evidence synthesis was conducted and reported in accordance with PRISMA guidelines and the ENTREQ. Three databases were systematically searched up to and including February 2022. Qualitative research relating to the physical activity of adults with intellectual disabilities were included. Thematic synthesis was conducted with themes mapped onto the COM‐B model.ResultsTwenty‐five studies were included. Influences of physical activity were identified and mapped onto the COM‐B model, which also included COM‐B influences of social support provided by caregivers.ConclusionsThere are many complex influences of physical activity for adults with intellectual disabilities. Researchers should consider the influences contributing to caregivers' capacity to support physical activity.
Crebanine mitigates glucocorticoid‐induced osteonecrosis of the femoral head by restoring bone remodelling homeostasis via attenuating oxidative stress
Authors: Dong Shankun , Ge Jianxun , Meng Qi , Yuan Tao , Wang Yi , Li Yi , Lu Qizhen , Song Wenao , Li Ziqing , Sun Shui 
Published: August 2024

AbstractThe onset of osteonecrosis of the femoral head (ONFH) is intimately associated with the extensive administration of glucocorticoids (GCs). Long‐term stimulation of GCs can induce oxidative stress in both osteoclasts (OCs) and osteoblasts (OBs), resulting in the disturbance of bone remodelling. An alkaloid named crebanine (CN) demonstrates pharmacological properties including anti‐inflammation and reactive oxygen species (ROS) modulation. Our objective is to assess the therapeutic potential of CN in treating ONFH and elucidate the associated underlying mechanisms. The network pharmacology analysis uncovered that CN played a role in regulating ROS metabolism. In vitro, CN demonstrated its ability to reduce the dexamethasone (DEX)‐stimulated generation of OCs and suppress their resorptive function by downregulating the level of osteoclast marker genes. Concurrently, CN also mitigated DEX‐induced damage to OBs, facilitating the restoration of osteoblast marker gene expression, cellular differentiation and function. These effects were achieved by CN augmenting the antioxidant system to reduce intracellular ROS levels. Furthermore, in vitro results were corroborated by micro‐CT and histological data, which also showed that CN attenuated MPS‐induced ONFH in mice. This study highlights the therapeutic potential of CN in counteracting GCs‐induced ONFH.
Emerging ways to extract lycopene from waste of tomato and other fruits, a comprehensive review
Authors: Chaudhary Kashmala , Khalid Samran , Zahid Muqaddas , Ansar Sadia , Zaffar Mahnoor , Hassan Syed Ali , Naeem Muhammad , Maan Abid Aslam , Aadil Rana Muhammad 
Published: August 2024

AbstractLycopene is a coloring substance with significant value as a natural food color, along with recognized medicinal and therapeutic properties. Fruit waste is produced in huge amounts by fruit processing industries. The extraction of lycopene from this waste is a promising strategy, for its application in food, pharmaceutical and cosmetic industries. This review summarizes the innovative techniques utilized for extracting lycopene from the waste of tomato, papaya, pink guava, seabuckthorn berries, and apricots. The goal is to assess the effectiveness of contemporary methods and underscore their ability to improve the sustainability and extraction efficiency of this valuable substance. Conventional extraction techniques have long been utilized for extracting this pigment from fruit waste materials, but these techniques have several drawbacks. Novel techniques such as ultrasound‐assisted extraction, microwave‐assisted extraction, pulsed electric field‐assisted extraction, enzyme‐assisted extraction, high hydrostatic pressure‐assisted extraction, and super‐critical fluid extraction provide higher extraction yields as compared to conventional extraction techniques, by using a smaller amount of solvents. These techniques offer improved efficiency, reduced extraction time, increased selectivity, minimized degradation, preserved bioactivity of lycopene, and environmental friendliness.
Adjusting to living with chronic liver disease among patients who continue regular healthcare visits for hepatocellular carcinoma surveillance: A grounded theory study
Authors: Hatanaka Keiko , Sasaki Yoshiko , Tanaka Makoto 
Published: August 2024

AbstractAimTo explore patients' process of living with chronic liver disease while continuing regular healthcare visits for hepatocellular carcinoma surveillance.MethodsSemistructured interviews and participant observations were conducted in this qualitative constructivist grounded theory study. The participants included 11 patients undergoing regular hepatocellular carcinoma surveillance every 1–6 months for 2–30 years. Data were analyzed using coding, memo‐writing, theoretical sampling, and constant comparison.ResultsThe participants incorporated regular healthcare visits into their living cycle. The cycle's core comprised two categories (“inferring my liver condition” and “desiring status quo”). The cycle underwent a transition described by three phases (“seeking ways to live with my chronic liver disease,” “being overwhelmed by living with my chronic liver disease,” and “reconstructing my life to live with my chronic liver disease”). This transition involved adjusting to living with chronic liver disease while continuing regular healthcare visits. The relative importance of the cycle's core progressively shifted from “inferring my liver condition” to “desiring status quo.”ConclusionsThis study revealed the transition phases of patients' living cycles in adjusting to living with chronic liver disease while continuing regular healthcare visits. Understanding the different phases in which patients are and the psychological impact of healthcare visits can help them look forward to recuperative actions. Furthermore, patients who have a sense of ownership experience loneliness because of regular healthcare visits. A support system including nurses as part of regular hepatocellular carcinoma surveillance should be established to help ease patients' sense of loneliness by utilizing their sense of ownership.
Safety and efficacy of intralesional bleomycin for keloids and hypertrophic scars: A systematic review and meta‐analysis
Authors: You Shun Jie , Li Si , Hu Chen Ming , Zhong Fang Yu , Gan Shi Han , Cai Yan , Xiang Xiao Yan 
Published: August 2024

AbstractBackgroundBleomycin, originally an antitumor drug, was explored as a pathological scar treatment in the mid‐1990s. However, its efficacy and safety profile varies among individuals.AimsThis study aimed to assess topical bleomycin's efficacy and safety in treating hypertrophic scars and keloids.MethodsWe reviewed randomized controlled trials (RCTs) and controlled clinical trials (CCTs) published in English, comparing intralesional bleomycin to placebos or common intralesional scar treatments. Primary outcomes included percentage change in scar improvement, pigmentation, recurrence, atrophy, pain, telangiectasia, ulceration, patient self‐assessment, and observer assessment (>50%).ResultsSix trials met the criteria. Bleomycin significantly improved scar reduction compared to triamcinolone (p < 0.05). There was no significant difference in pigmentation (p = 0.05) and recurrence (p = 0.21) compared to other treatments. In terms of safety, bleomycin caused less skin atrophy (p < 0.01) and telangiectasia (p < 0.01) but more pain (p = 0.03) than other treatments.ConclusionsBleomycin was more effective than TAC, 5‐FU, or TAC combined with 5‐FU for treating keloids and hypertrophic scars with lower skin atrophy and telangiectasia risks. However, it may cause more pain than 5‐FU or TAC. Further comprehensive studies, including RCTs, are required for objective analysis.
Electoral consequences of globalization for social democratic parties across European regions
Authors: Mádr Michal 
Published: August 2024

AbstractThe paper investigates the influence of regional import shocks from low‐wage countries on electoral support for European social democratic parties in 289 NUTS2 regions (2002–2022). The estimates suggest that a one standard deviation increase in the import shock from low‐wage countries over an election period may lead to a decline in support for social democratic parties between 0.6 and 1.2 percentage points. Similar results also apply to imports from Asian economies, such as China and India. The negative impact on electoral support for social democratic parties is amplified in moderately industrial and predominantly rural regions. For the former, the decline in industrial employment led to a shift of social democratic voters to the radical right. In contrast, in the latter case, the relatively slower growth of employment in the tertiary and quaternary sectors and the peripheral position of these regions caused a shift to the radical left.