bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Ukuran Perusahaan, Leverage, Struktur Modal dan Likuiditas terhadap Kinerja Keuangan (Studi Kasus Perusahaan Subsektor Farmasi yang Terdaftar di BEI Tahun 2018-2022)
Authors: Jayandhika Bagus Kun Ardiansyah  , RB. Iwan Noor Suhasto  , Permatasari Cahyaningdyah  
Published: August 2024

Abstract : In the era of globalization, especially during the COVID-19 pandemic, the consumer goods industry, particularly the pharmaceutical subsector, has experienced rapid growth. Consequently, companies must manage aspects such as company size, leverage, capital structure, and liquidity to achieve optimal financial performance amid increasing competition. This study aims to examine the influence of company size, leverage, capital structure, and liquidity on the financial performance of pharmaceutical subsector companies listed on the Indonesia Stock Exchange for the period 2018-2022. This research employs a quantitative method. The sampling method used is purposive sampling, resulting in a sample of 11 pharmaceutical companies in Indonesia. This study uses classical assumption tests and hypothesis testing using SPSS (Statistical Program for Social Science) version 22. The results indicate that company size, leverage, and liquidity significantly influence financial performance, while capital structure does not affect the financial performance of pharmaceutical companies in Indonesia. The implications of this research suggest that leverage can provide practical benefits for pharmaceutical company management to fund expansion and R&D without requiring substantial equity capital, and can also reduce taxable income in accordance with Indonesian tax regulations.
Abstrak : Di era globalisasi saat terjadi COVID-19, industri barang konsumsi, khususnya subsektor farmasi, berkembang pesat sehingga perusahaan harus mengelola aspek-aspek seperti ukuran perusahaan, leverage, struktur modal, dan likuiditas untuk mencapai kinerja keuangan optimal di tengah persaingan yang meningkat. Penelitian ini bertujuan untuk menguji pengaruh ukuran perusahaan, leverage¸ struktur modal, dan likuiditas terhadap kinerja keuangan perusahaan subsektor farmasi yang terdaftar di Bursa Efek Indonesia periode 2018-2022. Penelitian ini menggunakan metode kuantitatif. Pengambilan sampel penelitian dilakukan dengan metode purposive sampling sehingga diperoleh sampel sebanyak 11 perusahaan farmasi di Indonesia. Penelitian ini menggunakan uji asumsi klasik dan uji hipotesis menggunakan aplikasi SPSS (Statistical Program for Social Science) versi 22. Hasil penelitian ini menunjukan bahwa ukuran perusahaan, leverage, dan likuiditas berpengaruh terhadap kinerja keuangan. Sedangkan struktur modal tidak berpengaruh terhadap kinerja keunagan perusahaan farmasi diindonesia. Implikasi dalam penelitian ini menunjukkan bahwa leverage dapat memberikan manfaat praktis bagi manajemen perusahaan farmasi untuk mendanai ekspansi dan R&D tanpa harus mengeluarkan modal ekuitas yang besar, serta dapat mengurangi penghasilan kena pajak sesuai dengan ketentuan perpajakan di Indonesia.
Dynamics of Islam and Politics in the Middle East region
Authors: Aris Munandar  
Published: August 2024

: The Middle East, a region steeped in religious history, is the birthplace of major religions such as Islam, Christianity, and Judaism. Religion profoundly influences the political and social order in this region, with Islam, as the majority religion, playing a crucial role in shaping state policies and political direction. The Iranian Revolution of 1979 was a pivotal event that reinforced the influence of Islam in politics. Subsequently, Islamic movements have impacted political changes, notably during the Arab Spring, which aimed to transition autocratic systems to democracy with varied outcomes. However, the region is also marked by long-standing conflicts driven by religious, ethnic, and economic interests, exacerbated by the discovery of abundant oil resources since the 1930s. Western intervention and local political dynamics have further complicated the geopolitical landscape, resulting in prolonged conflicts with global repercussions. This research employs a quantitative approach with descriptive methods, primarily relying on a literature review. The literature review involves analyzing relevant sources such as books, journals, and articles to identify key patterns and themes, providing insight into the region's problems. Historical analysis is also utilized to understand the evolution of theories and concepts over time. The synthesized findings offer a comprehensive understanding and propose alternative solutions to the region's challenges.
Planting of Nectar Plants as Feed of Butterflies Imago in Bantimurung Bulusaraung National Park
Authors: Suryanto Heri , Mangopang Albert Donatus 
Published: August 2024

Bantimurung Bulusaraung National Park is a forest area designated as a conservation area in Sulawesi. The diversity of flora and the presence of unique wildlife supported by the karst ecosystem are the basis for the protection of thia area. Community presure and habitat destruction is the causes of decreasing butterfly populations. Habitat rehabilitation need to be carried out in order to maintain the butterfly population. The understanding of diversity of butterfly species and the selection of protective tree species and animal nests or food are important aspects for sustainableliyty. Most of the types of forage plants are unknown species, so an understanding of planting methods in the field is needed. The research was conducted in observing the diversity of Rhopalocera (butterfly) species as a preliminary research and planting nectar-producing plants as the main research. Research result showed that Nymphalidae family is highest in species diversity index, Nymphalidae and Papilionidae family are highest in richness index, and all famiies are lowin species dominance index and evenness index. Nimphalidae and Papilionidae family is the largest species has been found. Planting nectar plants i.e mali-mali and dao on degraded land with fertilization treatment showed the best results are 600 grams per planting hole for mali-mali and 900 grams per planting hole for dao.
Narrative Review: The Potential Of Morus Alba And Morus Nigra As Anti-Inflammatory And Antioxidant
Authors: Indawati Iin , Kintoko  
Published: August 2024

Introduction: Oxidative stress causes various diseases. Inflammation is the body's response to tissue infections and injuries. Mulberry is a multifunctional plant with bioactive components that have potent antioxidant and anti-inflammatory activities. This study aims to determine the activity of antioxidants, anti-inflations, extraction processes, active compounds, and methods used for antioxidant and anti-inflammatory testing.
Methods: Narrative review using a literature search using Google Scholar and PubMed.
Results: The results of Morus alba and Morus nigra have antioxidant activity, the plant parts used by leaves, fruits, and roots. Various methods were used to determine antioxidant activity, including DPPH, reducing power assay, β-carotene bleaching, and Hydroxyl radical scavenger capacity.
Conclusion: Anti-inflammatory mechanism of mulberry bioactive compounds by inhibiting several cytokines and inflammatory mediators such as IL-1β, IL-6, IL-8, IL-9, IL-10, IL-23a, IFN-ɣ, TNF-ɑ, MMP-3, MMP-9, TLR, COX-2, NF-kB and iNOS. Testing of antioxidant activity by DPPH, ABTS, FRAP, reducing power assay, β-carotene bleaching, and Hydroxyl radical scavenger capacity
Degeneração Macular Relacionada à Idade: Etiologia, fisiopatologia e avanços no diagnóstico
Authors: Cohen Joanna Cyrene Duarte Chagas , Marques Felipe Costa de Oliveira , Silva Adriana Potratz da , Macedo Nathalia Faleiros , Araujo Maria Eduarda Rosendo de , Véras Raul Felipe Oliveira , Véras Saul Felipe Oliveira , Teixeira Lucas , Nery Daniela Luiz , Battistuz Flávia , Lençone Gustavo , Busano Igor Mariano , Almeida Lilian da Silva , Hupp Maria Vitória Sabino , Alves Felipe Vitor Borges , Giovanni Ciarlini  , Pires Giovana Teixeira 
Published: August 2024

A Degeneração Macular Relacionada à Idade (DMRI) é uma condição degenerativa que afeta a mácula, a área central da retina responsável pela visão detalhada e central, essencial para atividades como leitura, reconhecimento de rostos e visão de detalhes finos. Realizar uma revisão é de extrema importância para aprimorar o manejo e a compreensão dessa condição ocular complexa. A DMRI está em constante evolução com novas descobertas sobre sua fisiopatologia, diagnóstico e tratamento. Uma revisão abrangente oferece uma oportunidade para consolidar e atualizar as informações mais recentes, proporcionando aos profissionais de saúde uma visão clara e atualizada das melhores práticas e inovações terapêuticas. Foi empregada uma abordagem quantitativa na pesquisa, complementada pela inclusão de estudos qualitativos relevantes para uma compreensão abrangente do tema. A revisão dos estudos demonstra que a DMRI seca apresenta uma evolução gradual e é caracterizada pelo acúmulo de drusas sob a retina, resultando em perda progressiva da visão central. Em contraste, a DMRI úmida é mais agressiva e está associada à formação de vasos sanguíneos anômalos na coroide, causando perda rápida e severa da visão central devido ao vazamento de fluido e sangue. Estudos mostram que a prevalência e a gravidade da doença podem variar de acordo com fatores genéticos, ambientais e de estilo de vida. Entre os fatores de risco identificados estão o tabagismo, a hipertensão e uma dieta pobre em antioxidantes. A realização de pesquisas contínuas e o desenvolvimento de novas terapias são essenciais para enfrentar os desafios impostos pela DMRI e melhorar os resultados para os pacientes.
Políticas de saúde mental: Panorama nacional
Authors: Júlia Maria de Holanda Raulino  , Wilkerson Madson de Souza Alves  , Myrella de Jesus Cruz Gomes  , Celina Rodrigues Maia Santos  , Emile de Jesus Santos  , José Luan de Souza Andrade  , Manuela Luanny Ventura Rocha  , Alana Cavalcante Bezerra  , Cheila Porfírio da Costa  , Mateus de Souza Pereira  
Published: August 2024

Este artigo tem por objetivo analisar as políticas públicas existentes relacionadas à saúde mental no Brasil, identificar os desafios enfrentados para a sua implementação e manutenção e avaliar os impactos que têm na promoção da saúde mental da população brasileira. Trata-se de uma revisão integrativa da literatura, realizada nos materiais indexados na Biblioteca Virtual em Saúde (BVS): Medical Literature Analysis and Retrieval System Online (MEDLINE) e a Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS). Foram utilizados os Descritores em Ciências da Saúde (DeCS) em cruzamento com o operador booleano AND, da seguinte forma: “Saúde Mental” AND “Serviços de Saúde Mental” AND “Políticas de Saúde Pública” AND “Brasil”. Após a aplicação dos critérios de elegibilidade foram selecionados 10 (dez) estudos para compor essa revisão. As políticas de saúde mental no Brasil destacam a importância de fortalecer as redes regionalizadas de saúde mental, abordando desde a infraestrutura até a articulação entre os serviços. Faz-se necessário superar barreiras no acesso à rede de atenção psicossocial, especialmente para populações vulneráveis. Portanto, é imprescindível políticas de saúde mental que priorizem a dignidade, a autonomia e o bem-estar dos indivíduos, visando uma sociedade mais saudável e inclusiva.
The Usefulness of Colchicine in the Prevention of Contrast-induced Acute Kidney Injury in Patients Undergoing Elective Percutaneous Coronary Intervention
Authors: Ebaid Hany Hassan , Hamouda Mohamed Ahmed , Bakr Abdallah Adel Saleh , El-Sayed Amr Abd El-Mordy 
Published: August 2024

Background: Contrast-induced acute kidney injury (CIAKI) it is an important complication of diagnostic and interventional procedures in cardiology. This work aimed to to investigate the preventive role of colchicine on CI-AKI in patients undergoing elective PCI considering to its anti-inflammatory and renoprotective effects.
Methods: This study was conducted on 400 patients who were admitted for elective PCI, and was carried out in CCU in Cardiology Department, Benha university hospital and National Heart Institute. The patients were equally divided into two equal groups: Group 1 (Case group): received colchicine plus standard anti ischemic treatment and croup 2 (Control group): received placebo plus standard anti ischemic treatment. All patients were subjected to standard 12-lead ECG, laboratory investigations encompassing kidney function tests 24 hours before the procedure and 48 hours after, random blood sugar, coagulation profile, liver function tests. and serum electrolytes and transthoracic echocardiography.
Results: There was a significant positive correlation between Serum creatinine and diabetes mellitus (r=0.245, P=0.001) and eGFR (r= 0.174, P<0.001). The multivariate regression analysis revealed that age, Colchicine use, diabetes mellitus, post CAG creatinine and post CAG eGFR, were the only significant predictors of incidence of CI-AKI.
Conclusions: Colchicine, when administered in conjunction with standard anti-ischemic treatment in patients undergoing elective PCI, significantly reduces the incidence of CI-AKI. The reduction in CI-AKI incidence not only has implications for patient outcomes but also reveals an important strategy in optimizing renal protection during PCI.
Enhancing Early Childhood Learning through Effective Communication in Beyond Centers and Circle Time Activities
Authors: Hilyati Samihah , Rusijono  , Mariono Andi , Arianto Fajar 
Published: August 2024

Aims: This study aims to analyze the improvement of early childhood learning through effective communication in Beyond Centers and Circle Time activities on children's cognitive and language development.
Study Design: The research used quantitative research with a quasi-experimental research design.
Place and Duration of Study: The research sample was from children of Khodijah Kindergarten Wonorejo, Wonokromo and Pandegiling Surabaya. This research was conducted between February and March 2024.
Methodology: The study sample consisted of 60 children, 30 children in the experimental group and 30 children in the control group. The 10 children in each group were representative of the three kindergartens used in the study. Data collection used tests to test cognitive development and performance to test children's language development. Data analysis used homogeneity test, normality test, and t test.
Results: The results of the analysis obtained a value of 0.029 <0.050 which indicates a significant increase in effective communication in early childhood in Beyond Centers and Circle Time learning on cognitive development and the results of the analysis obtained a value of 0.003 <0.050 which indicates a significant increase in effective communication in early childhood in Beyond Centers and Circle Time learning on child language development. Structured communication during Beyond Centers and Circle Time activities has improved children's cognitive and language skills for the better. In particular, children were able to show better attention during learning activities, improve peer interactions, and engage themselves in learning activities, all due to the role of effective communication during these learning activities.
Conclusion: It was found that increasing effective communication in early childhood learning in Beyond Centers and Circle Time learning can affect early childhood cognitive and language development. Suggestions for future researchers, the hope is to continue research related to Beyond Centers and Circle Time learning, it could be that this learning could have other benefits in early childhood skills or knowledge. Or it can be applied in early childhood education institutions in other areas because the problems in each educational institution must be different. And it can also be a source of reference or new information for further research that explores this learning or related to effective communication in early childhood learning.
Surface slip and off‐fault deformation patterns in the 2013 MW 7.7 Balochistan, Pakistan earthquake: Implications for controls on the distribution of near‐surface coseismic slip
Authors: Zinke Robert , Hollingsworth James , Dolan James F. 
Published: December 2014

AbstractComparison of 398 fault offsets measured by visual analysis of WorldView high‐resolution satellite imagery with deformation maps produced by COSI‐Corr subpixel image correlation of Landsat‐8 and SPOT5 imagery reveals significant complexity and distributed deformation along the 2013 Mw 7.7 Balochistan, Pakistan earthquake. Average slip along the main trace of the fault was 4.2 m, with local maximum offsets up to 11.4 m. Comparison of slip measured from offset geomorphic features, which record localized slip along the main strand of the fault, to the total displacement across the entire width of the surface deformation zone from COSI‐Corr reveals ∼45% off‐fault deformation. While previous studies have shown that the structural maturity of the fault exerts a primary control on the total percentage of off‐fault surface deformation, large along‐strike variations in the percentage of strain localization observed in the 2013 rupture imply the influence of important secondary controls. One such possible secondary control is the type of near‐surface material through which the rupture propagated. We therefore compared the percentage off‐fault deformation to the type of material (bedrock, old alluvium, and young alluvium) at the surface and the distance of the fault to the nearest bedrock outcrop (a proxy for sediment thickness along this hybrid strike slip/reverse slip fault). We find significantly more off‐fault deformation in younger and/or thicker sediments. Accounting for and predicting such off‐fault deformation patterns has important implications for the interpretation of geologic slip rates, especially for their use in probabilistic seismic hazard assessments, the behavior of near‐surface materials during coseismic deformation, and the future development of microzonation protocols for the built environment.
Efficacy of delayed‐release dimethyl fumarate in relapsing‐remitting multiple sclerosis: integrated analysis of the phase 3 trials
Authors: Viglietta Vissia , Miller David , Bar‐Or Amit , Phillips J. Theodore , Arnold Douglas L. , Selmaj Krzysztof , Kita Mariko , Hutchinson Michael , Yang Minhua , Zhang Ray , Dawson Katherine T. , Sheikh Sarah I. , Fox Robert J. , Gold Ralf 
Published: December 2014

AbstractObjectiveObtain a more precise estimate of the efficacy of delayed‐release dimethyl fumarate (DMF; also known as gastro‐resistantDMF) in relapsing multiple sclerosis (MS) and examine the consistency ofDMF's effects across patient subgroups stratified by baseline demographic and disease characteristics.MethodsA prespecified integrated analysis of the randomized, double‐blind, placebo‐controlled, Phase 3DEFINEandCONFIRMtrials was conducted.ResultsThe intent‐to‐treat population comprised 2301 patients randomized to receive placebo (n = 771) orDMF240 mg twice daily (BID;n = 769) or three times daily (TID;n = 761). At 2 years,DMF BIDandTIDreduced the annualized relapse rate by 49% and 49% (bothP < 0.0001), risk of relapse by 43% and 47% (bothP < 0.0001), risk of 12‐week confirmed disability progression by 32% (P = 0.0034) and 30% (P = 0.0059), and risk of 24‐week confirmed disability progression by 29% (P = 0.0278) and 32% (P = 0.0177), respectively, compared with placebo. In a subset of patients (MRIcohort),DMF BIDandTIDreduced the mean number of new/enlarging T2‐hyperintense lesions by 78% and 73%, gadolinium‐enhancing lesion activity by 83% and 70%, and mean number of new nonenhancing T1‐hypointense lesions by 65% and 64% (allP < 0.0001 vs. placebo). Effects were generally consistent across patient subgroups.InterpretationThe integrated analysis provides a more precise estimate ofDMF's efficacy.DMFdemonstrated a robust reduction in disease activity and a consistent therapeutic effect across patient subgroups.
A Candid Approach to Clay Modification via Dehydroxylation for Nanocomposites Application: Investigation of Degradation Kinetics, Reaction Model, and Flammability
Authors: Pandey Priyanka , Mohanty Smita , Nayak Sanjay K 
Published: December 2014

ABSTRACTA candid approach to thermal dehydroxylation was used for the modification of clay, to achieve improved thermal stability of a polymer nanocomposite. The modification of clay using alkyl ammonium salt has been found disadvantageous due to various aspects; hence the approach to dehydroxylation was an innovative step to overcome the difficulties in achieving a thermally stable polymer clay nanocomposite. Therefore, a detailed study of thermal stability of polymer clay nanocomposites has been carried out using isoconversional TGA methods of Flynn–Wall–Ozawa and Kissinger. Also, the reaction model involved in the decomposition process of polypropylene (PP) and its nanocomposites have been investigated. From the thermal kinetic analysis, it was clear that the thermal dehydroxylation method can be used as an effective approach for clay modification and the use of organic alkyl ammonium salt can be avoided. Furthermore, to predict the flame‐retardant effectiveness of the thermally dehydroxylated clay, the cone calorimeter analysis was carried out. A comparison of the flame‐retardant effectiveness of the organophillic clay and thermally dehydroxylated clay was presented.
Artificial weathering effect on the structure and properties of polypropylene/polyamide‐6 blends compatibilized with PP‐g‐MA
Authors: Mouffok Samir , Kaci Mustapha 
Published: December 2014

ABSTRACTThe degradation of uncompatibilized and compatibilized PP/PA‐6 (70/30 wt %) with PP‐g‐MA under accelerated UV light was investigated using Fourier Transform Infrared Spectroscopy (FTIR) spectroscopy, melt flow index (MFI) tester, tensile test, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). FTIR analysis of the structure of the compatibilized and uncompatibilized blends after exposure to UV light showed the formation of photoproducts corresponding to both components. The MFI and mechanical results obtained revealed that photooxidation started primarily in PA‐6 rather than PP. In addition, the uncompatibilized blends exhibited a higher degradation rate compared to neat polymers for long exposure time, and the addition of PP‐g‐MA increased slightly their ageing rate in accordance with TGA data. Further, DSC analysis showed an increase in the crystallinity index and a decrease in the melting temperature of PP and PA‐6 after UV exposure either as neat polymers or as blend components. SEM micrographs of the cryo‐fractured surfaces of the samples illustrated the formation of cracks and fractures after UV irradiation. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41722.