bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACEF and clinical SYNTAX score in the risk stratification of patients with heavily calcified coronary stenosis undergoing rotational atherectomy with stent implantation
Authors: Pyxaras Stylianos A. , Mangiacapra Fabio , Wijns William , Di Serafino Luigi , De Vroey Frederic , Toth Gabor , Sinagra Gianfranco , De Bruyne Bernard , Heyndrickx Guy R. , Barbato Emanuele 
Published: January 2014

AimTo assess ACEF (age, creatinine, and ejection fraction) and Clinical SYNTAX (CSS) score in the risk stratification of patients with heavily calcified stenosis undergoing rotational atherectomy with stent implantation (rota‐stenting). Methods and Results. ACEF and CSS were calculated in 221 consecutive patients with stable angina undergoing rota‐stenting. Mean age of the patients was 74 ± 10 years, left ventricular ejection fraction was 61 ± 18%, and final burr size 1.78 ± 0.24 mm, with 2.6 ± 0.9 burrs used for each patient. Primary end‐point was MACE at one‐year defined as the composite of cardiac death, myocardial infarction, and target vessel revascularization. Post‐hoc analysis was performed by stratifying the clinical outcome according to ACEF and CSS tertiles. At 1 year there was a significantly higher MACE rate in the high tertile of ACEF (24% for ACEFHigh vs. 13% for ACEFMid vs. 9% for ACEFLow; P = 0.017) and CSS (25% for CSSHigh vs. 12% for CSSMid vs. 8% for CSSLow; P = 0.008). The predictive accuracy for both ACEF and CSS was moderate (c‐statistics, 0.629 and 0.638, respectively).ConclusionBoth ACEF and CSS predict with moderate accuracy MACE at 1‐year in patients with heavily calcified coronary stenosis undergoing rotational atherectomy with stent implantation. © 2014 Wiley Periodicals, Inc.
Artificial Nucleobase–Amino Acid Conjugates: A New Class of TAR RNA Binding Agents
Authors: Joly Jean‐Patrick , Mata Guillaume , Eldin Patrick , Briant Laurence , Fontaine‐Vive Fabien , Duca Maria , Benhida Rachid 
Published: January 2014

AbstractThe human immunodeficiency virus type‐1 (HIV‐1) Tat protein stimulates transcriptional elongation. Tat is involved in the transcription machinery by binding to the transactivation response region (TAR) RNA stem‐loop structure, which is encoded by the 5′ leader sequence found in all HIV‐1 mRNAs. Herein, we report the rational design, synthesis, and in vitro evaluation of new RNA binding agents that were conceived in order to bind strongly and selectively to the stem‐loop structure of TAR RNA and, thus, inhibit the Tat/TAR interaction. We have demonstrated that the conjugation of modified nucleobases, able to interact specifically with an RNA base pair, and various amino acids allows these motifs to bind the target RNA selectively and in a cooperative manner that leads to the inhibition of viral replication in HIV‐infected cells.
Acetylenic Homocoupling Methodology Towards the Synthesis of 1,3‐Butadiynyl Macrocycles: [142]‐Alleno‐Acetylenic Cyclophanes
Authors: Lahoz Inmaculada R. , Navarro‐Vázquez Armando , Alonso‐Gómez José Lorenzo , Cid M. Magdalena 
Published: January 2014

Abstract[142]‐Alleno‐acetylenic cyclophanes were synthesized through two different approaches: an intermolecular coupling between two alkynyl fragments, and an intramolecular ring‐closure of a linear acyclic bisalkynyl oligomer. The symmetry of the target dictates the choice of the most suitable method. To illustrate these approaches we have used 1,3‐diethynyl‐substituted allenes as building blocks. Due to the stereogenic character of the allene moiety, the alleno‐acetylenic cyclophanes were obtained as a mixture of diastereoisomers, and the major twist isomers were resolved by preparative HPLC. The different symmetry of the isomers allowed the assignment of the relative configuration of the major twist isomers by taking into consideration the number of nonequivalent groups in the respective NMR spectra.
Development of an optoelectronic integrated circuit for indoor optical wireless communication systems
Authors: Brandl P. , Zimmermann H. 
Published: January 2014

ABSTRACTIndoor optical wireless communication systems use in most cases discrete built receivers. The analogue part of receivers consists of a photodetector and an amplifier. In this paper, we present a fully integrated optoelectronic integrated circuit that combines a photodetector and an amplifier into one single receiver chip. We show the evolution of such receivers and examine the benefits of their production as standard semiconductor chip. We developed a fully integrated receiver for a 3Gbit/s communication in standard BiCMOS technology. We expanded the receiver by additional photodetectors to have the possibility of implementing an automatic alignment system. To demonstrate the performance of this receiver, we built a complete indoor optical wireless communication system. We increased the working area of the system by applying two strategies at the transmitter side. First, we used an adaptive optical system to influence the laser spot diameter. Second, to steer the laser beam, we included a micro‐electro‐mechanical system. Copyright © 2014 John Wiley & Sons, Ltd.
Outage probability analysis of optimal and suboptimal interference aware routing protocols for multihop underlay cognitive radio networks
Authors: Touati Sami , Boujemaa Hatem , Abed Nazha 
Published: January 2014

ABSTRACTIn this paper, optimal and suboptimal routing protocols are proposed for cognitive radio networks. We first investigate optimal routing protocol that consists in searching among all available paths, the one that minimises the end‐to‐end outage while verifying interference constraint to primary receiver. A suboptimal one‐hop routing protocol is proposed where the best relay is selected in each hop. The last routing protocol consists in decomposing the network in many subnetworks composed of K hops. Then, the best route is determined in each of these subnetworks so that the K‐hops outage probability is minimised. The proposed K‐hops routing protocol allows a good compromise between complexity and performance. The outage probability of the different routing protocols is evaluated theoretically and through simulation results.Copyright © 2014 John Wiley & Sons, Ltd.
Application of the finite point method to high‐Reynolds number compressible flow problems
Authors: Ortega Enrique , Oñate Eugenio , Idelsohn Sergio , Flores Roberto 
Published: January 2014

SUMMARYIn this work, the finite point method is applied to the solution of high‐Reynolds compressible viscous flows. The aim is to explore this important field of applications focusing on two main aspects: the easiness and automation of the meshless discretization of viscous layers and the construction of a robust numerical approximation in the highly stretched clouds of points resulting in such domain areas. The flow solution scheme adopts an upwind‐biased scheme to solve the averaged Navier–Stokes equations in conjunction with an algebraic turbulence model. The numerical applications presented involve different attached boundary layer flows and are intended to show the performance of the numerical technique. The results obtained are satisfactory and indicative of the possibilities to extend the present meshless technique to more complex flow problems. Copyright © 2014 John Wiley & Sons, Ltd.
Improved Quality Output through Computer‐Based Training: An Automotive Assembly Field Study
Authors: Malmsköld Lennart , Örtengren Roland , Svensson Lars 
Published: January 2014

AbstractIn this article, two field experiments, conducted in an automotive assembly plant, evaluate how computer‐based training of operational sequences and related quality information can support the assembly performance of the operators. The experiments were performed during the launch of a new vehicle. A comparison was made of learning progress and quality performance between a reference group of operators that only had regular training and a test group for which some of the regular training was replaced with individual computer‐based training. Both quantitative measures of the quality output and questionnaires and observations were used to evaluate the effects of computer‐based training. The results show a clear positive difference in learning progress and improvements in quality output for the test group compared with the reference group. This combined with positive attitudes expressed by the operators and their team leaders shows that this type of training is an effective way to train operators during launches of new vehicles in automotive production.
A naturalistic comparison study of the efficacy and safety of intramuscular olanzapine, intramuscular haloperidol, and intramuscular levomepromazine in acute agitated patients with schizophrenia
Authors: Suzuki Hidenobu , Gen Keishi , Takahashi Yuki 
Published: January 2014

ObjectiveThis study was a comparative investigation of the clinical efficacy and safety of intramuscular (IM) olanzapine, IM haloperidol, and IM levomepromazine in acute agitated patients with schizophrenia.MethodsThe subjects were 122 inpatients. Their clinical symptoms were assessed using Positive and Negative Syndrome Scale Excited Component (PANSS‐EC), PANSS, and Agitation–Calmness Evaluation Scale, and their safety were assessed using the Abnormal Involuntary Movement Scale, Barnes Akathisia Rating Scale (BARS), and Drug‐induced Extrapyramidal Symptoms Scale (DIEPSS).ResultsThe mean changes from baseline on the PANSS‐EC, Agitation–Calmness Evaluation Scale, Abnormal Involuntary Movement Scale, BARS, and DIEPSS scores were significantly better in both IM olanzapine and IM levomepromazine than in IM haloperidol. Of these, the mean changes from baseline on the BARS and DIEPSS scores were significantly better in IM olanzapine than in IM levomepromazine. The mean change from baseline on the PANSS positive score was significantly better in both IM olanzapine and IM haloperidol than in IM levomepromazine.ConclusionsThe results of this study suggest the possibility that the anti‐agitation effects of IM olanzapine and IM levomepromazine are more rapid than those of IM haloperidol. No worsening of EPS was observed. Our results also suggest that compared with IM levomepromazine, IM olanzapine is safer and affords greater improvement in symptoms. Copyright © 2014 John Wiley & Sons, Ltd.
Crosslinking of saphenous vein ECM by procyanidins for small diameter blood vessel replacement
Authors: Zhai Wanyin , Zhang Hongxia , Wu Chengtie , Zhang Jiamin , Sun Xiaoning , Zhang Hongfeng , Zhu Ziyan , Chang Jiang 
Published: January 2014

AbstractXenogenic decellularized vessels, mainly composed of extracellular matrices (ECMs), are thought to be one of the alternative resources of small‐diameter blood vessels due to abundant source, tubular configuration, vascular microstructure, and good cytocompatibility. However, the main shortcomings of ECM vessels are their low chemical stability, easy calcification, immunogenicity, and high risk of thrombogenicity. Previous studies have shown that, glutaraldehyde (GA), as a crosslinking agent, led to significant calcification and cytotoxicity for the prepared ECM substitutes. To overcome the drawbacks of pure and GA‐crosslinked vascular alternatives of small‐diameter blood vessels, procyanidins (PC), a naturally derived polyphenol with anti‐inflammatory and platelet aggregation inhibiting bioactivities, was applied to crosslink the decellularized bovine saphenous vein ECM (svECM). After crosslinking, the obtained svECM substitutes exhibited natural tubular configuration with significantly improved mechanical properties, proper resistance to proteolysis, high chemical stability, and excellent anticalcification property. The PC‐crosslinked svECM substitutes were cytocompatible for cells adhesion and proliferation, and blood compatible for erythrocytes with far less hemolysis than that of safety standard. Furthermore, the PC‐crosslinked svECM substitutes showed distinct antithrombosis and anti‐immunogenicity potential. With these advantages, it is suggested that the PC‐crosslinked svECM may be used as a practical substitutes of small diameter blood vessels. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1190–1198, 2014.
TP53 and CDKN2a mutations in never‐smoker oral tongue squamous cell carcinoma
Authors: Heaton Chase M. , Durr Megan L. , Tetsu Osamu , van Zante Annemieke , Wang Steven J. 
Published: January 2014

Objectives/HypothesisTo determine the incidence and clinical significance of TP53 and CDKN2a somatic mutations in never smokers with oral tongue squamous cell carcinoma (OTSCC).Study DesignCase series.MethodsFifty‐one paraffin‐embedded tumors from never smokers with OTSCC were obtained. p53 and p16 expression was determined by immunohistochemical (IHC) staining. Tumor DNA was amplified by polymerase chain reaction, and direct sequencing and mutation analysis was performed. Statistical relationships among p53 and p16 IHC findings, TP53 and CDKN2a mutation status, and clinicopathologic characteristics were determined. Univariate and multivariate Cox models for survival were performed.ResultsSixteen tumors (31.4%) showed strong expression of p53 by IHC. There was no correlation between p53 status and clinicopathologic variables or survival outcomes. TP53 mutations were seen in 10 tumors (19.6%). Patients with TP53 mutations had higher tumor‐node‐metastasis (TNM) stage (P = 0.049), worse tumor differentiation (P = 0.025), earlier recurrence (P = 0.024), and more often died from their disease (P = 0.043) than those without mutations. Five tumors (9.8%) showed p16 positivity by IHC. There was no correlation between p16 status and clinicopathologic variables or survival. CDKN2a mutations were seen in four tumors (7.8%). Patients with CDKN2a mutations had earlier recurrence (P = 0.019) and more often died from their disease (P = 0.010) than those without mutations. Kaplan‐Meier curves show worse disease‐free survival (P = 0.0162, P = 0.0025) and overall survival (P = 0.0095, P = 0.0001) for TP53 and CDKN2a mutations, respectively. Multivariate analysis demonstrated that TP53 and CDKN2a mutations were independent predictors of disease‐free survival (P = 0.038 and P = 0.039, respectively).ConclusionsTP53 and CDKN2a mutations in never‐smoker OTSCC are associated with worse clinicopathologic characteristics and poorer survival outcomes.Level of EvidenceN/A. Laryngoscope, 124:E267–E273, 2014
On the role of shot noise in carrier‐envelope phase stabilization
Authors: Borchers Bastian , Anderson Alexandria , Steinmeyer Günter 
Published: January 2014

AbstractThis paper represents a systematic investigation of detection shot noise in carrier‐envelope phase (CEP) stabilization. Numerical simulations are conducted to calculate the influence of shot noise in laser oscillators. These results are compared with experimental results for Ti:sapphire lasers. It is found that shot noise imposes a limitation for obtaining sub‐100 mrad CEP jitters. Careful interferometer design is necessary to push this limit toward 10 mrad. In contrast to oscillator stabilization, shot noise appears to play a much more restrictive role in amplifier stabilization. Using spectral interferometry together with spectral broadening in sapphire, it already appears practically challenging to reach sub‐100 mrad jitters. Adaption of the optical nonlinearity in the broadening step appears key to further improvements of the CEP jitter of amplified systems. We believe that these improvements open a perspective for currently unfeasible applications of CEP stabilized pulses. Moreover, our considerations can be easily adapted to CEP stabilization of other laser types beyond Ti:sapphire.
Dilatation of the supra‐pineal recess on prenatal imaging: early clue for obstructive ventriculomegaly downstream of the third ventricle
Authors: Azzi Caroline , Giaconia Marie‐Brune , Lacalm Audrey , Massoud Mona , Gaucherand Pascal , Guibaud Laurent 
Published: January 2014

ABSTRACTObjectiveThe objective of this article is to describe the diagnostic significance of prenatal identification of dilated supra‐pineal recess (SPR) in cases of ventriculomegaly.MethodA retrospective study, based on neurosonography and magnetic resonance imaging, of a series of five prenatal cases referred to our institution because of ventriculomegaly associated with dilatation of the SPR.ResultsVentriculomegaly of obstructive origin was diagnosed in all cases and related to obstruction downstream of the third ventricle. The diagnosis in the five prenatal cases, confirmed on early post‐natal imaging, included the following: malformative aqueductal stenosis, ischemic–haemorrhagic parenchymal supra‐tentorial insult complicated by aqueductal stenosis, Blake's pouch cyst, cystic lesion of the posterior fossa and sub‐ependymal haemorrhage and Dandy–Walker malformation. In all cases, the third ventricle was prominent and associated with a dilated SPR. In two cases, the dilatation of the SPR was an early clue to e obstructive ventriculomegaly, which was initially minor and became severe on follow‐up imaging.ConclusionThe presence of a dilated SPR prenatally in the presence of even mild ventriculomegaly should prompt evaluation and follow‐up for the presence of obstructive ventriculomegaly with obstruction located downstream of the third ventricle. © 2014 John Wiley & Sons, Ltd.
Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis
Authors: Kumar Nitin , Radhakrishnan Abhijith , Wright Catherine C. , Chou Tsung‐Han , Lei Hsiang‐Ting , Bolla Jani Reddy , Tringides Marios L. , Rajashankar Kanagalaghatta R. , Su Chih‐Chia , Purdy Georgiana E. , Yu Edward W. 
Published: January 2014

AbstractThe Rv1217c–Rv1218c multidrug efflux system, which belongs to the ATP‐binding cassette superfamily, recognizes and actively extrudes a variety of structurally unrelated toxic chemicals and mediates the intrinsic resistance to these antimicrobials in Mycobacterium tuberculosis. The expression of Rv1217c–Rv1218c is controlled by the TetR‐like transcriptional regulator Rv1219c, which is encoded by a gene immediately upstream of rv1218c. To elucidate the structural basis of Rv1219c regulation, we have determined the crystal structure of Rv1219c, which reveals a dimeric two‐domain molecule with an entirely helical architecture similar to members of the TetR family of transcriptional regulators. The N‐terminal domains of the Rv1219c dimer are separated by a large center‐to‐center distance of 64 Å. The C‐terminal domain of each protomer possesses a large cavity. Docking of small compounds to Rv1219c suggests that this large cavity forms a multidrug binding pocket, which can accommodate a variety of structurally unrelated antimicrobial agents. The internal wall of the multidrug binding site is surrounded by seven aromatic residues, indicating that drug binding may be governed by aromatic stacking interactions. In addition, fluorescence polarization reveals that Rv1219c binds drugs in the micromolar range.
Performance of a One‐Dimensional Hydraulic Model for the Calculation of Stranding Areas in Hydropeaking Rivers
Authors: Casas‐Mulet R. , Alfredsen K. , Boissy T. , Sundt H. , Rüther N. 
Published: January 2014

AbstractFish stranding is a critical issue in rivers with peaking operations. The ability to accurately predict potential stranding areas can become a decisive factor to assess environmental impacts and to plan mitigation measures. The presented work shows that common procedures suggested in the literature in the use of one‐dimensional (1D) models for flood zone mapping are not always applicable to compute stranding areas. Specific and easy‐to‐understand guidance needs to be given for smaller‐scale issues. We provide specific guidelines to accurately predict potential stranding areas in a cost‐effective manner. By analysing four different river morphologies in detail in a peaking river, we find that the optimal geometry effort (number of cross sections) does not necessarily coincide with the maximum and it varies between channel types according to river physical characteristics such as sinuosity and channel complexity. The use of a 1D model can provide good estimates with an optimal geometry layout. Copyright © 2014 John Wiley & Sons, Ltd.
Breast Cancer, Aromatase Inhibitor Therapy, and Sexual Functioning: A Pilot Study of the Effects of Vaginal Testosterone Therapy
Authors: Dahir Melissa , Travers-Gustafson Dianne 
Published: January 2014

Abstract

Introduction
Women with breast cancer have better cancer-related outcomes with the use of aromatase inhibitors (AIs), but the physiological suppression of estradiol can negatively affect sexual functioning because of unpleasant urogenital and vaginal symptoms. Local health care practitioners have observed that the benefits of vaginal testosterone in allaying these unpleasant symptoms in women with breast cancer are similar to the benefits of vaginal estrogen in women without breast cancer.

Aim
The aim of this study was to evaluate the effects of using a daily vaginal testosterone cream on the reported sexual health quality of life in women with breast cancer taking AI therapy.

Methods
Thirteen postmenopausal women with breast cancer on AI therapy and experiencing symptoms of sexual dysfunction were recruited from an oncology practice. The women were prescribed a 300 μg testosterone vaginal cream daily for 4 weeks. During the first study visit, a vaginal swab was obtained to rule out the presence of Candida species or Gardnerella vaginalis in participants. Women with positive vaginal swabs were treated prior to starting the vaginal testosterone therapy.

Main Outcome Measure
The Female Sexual Function Index (FSFI) survey, measuring female sexual health quality of life, was administered during the first study visit and at the final study visit, after completing testosterone therapy.

Results
Twelve patients completed 4 weeks of daily vaginal testosterone therapy. When compared with baseline FSFI scores, there was a statistically significant improvement for individual domain scores of desire (P = 0.000), arousal (P = 0.002), lubrication (P = 0.018), orgasm (P = 0.005), satisfaction (P = 0.001), and pain (P = 0.000). Total domain scores reflecting sexual health quality of life also improved when compared with baseline (P = 0.000).

Conclusions
The use of a compounded testosterone vaginal cream applied daily for 4 weeks improves reported sexual health quality of life in women with breast cancer taking AIs.
The First Structurally Characterized Salts of Deprotonated Urea: M(CN2H3O) with M = Na, K, Rb, and Cs
Authors: Sawinski Hannah , Dronskowski Richard 
Published: January 2014

AbstractThe ureates of the alkali metals Na – Cs were synthesized from urea and the metals in liquid ammonia at temperatures below 50 °C. The crystal structures were determined using single‐crystal X‐ray diffraction. NaCN2H3O crystallizes in the monoclinic system [P21/c, Z = 16, a = 17.529(1) Å, b = 6.4784(5) Å, c = 10.8211(9) Å, β = 96.938(1)°]. All other ureates are orthorhombic, with KCN2H3O and RbCN2H3O being isotypic [Pbca, Z = 8, KCN2H3O: a = 7.102(4) Å, b = 7.221(4) Å, c = 13.533(8) Å; RbCN2H3O: a = 7.1973(8) Å, b = 7.3531(8) Å, c = 13.921(2) Å]. CsCN2H3O adopts a smaller unit cell [P212121, Z = 4, a = 6.3520(3) Å, b = 7.1645(4) Å, c = 9.0911(5) Å]. The ureates of K, Rb, and Cs contain hydrogen‐bond networks, the imino nitrogen atom acting as the hydrogen‐bond acceptor in CsCN2H3O. In KCN2H3O and RbCN2H3O, however, the carbonyl oxygen atom accepts the hydrogen bonds.