bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age‐related treatment patterns in sickle cell disease patients and the associated sickle cell complications and healthcare costs
Authors: Blinder Morey A. , Vekeman Francis , Sasane Medha , Trahey Alex , Paley Carole , Duh Mei Sheng 
Published: January 2013

AbstractBackgroundThis study explored the blood transfusion patterns, SCD complications, utilization of iron chelation therapies (ICT), healthcare resource use, and costs in pediatric, transitioning (18 years old) and adult patients with SCD.ProcedureData from Florida (1998–2009), New Jersey (1996–2009), Missouri (1997–2010), Kansas (2001–2009), and Iowa (1998–2010) state Medicaid were used. Patients with ≥2 SCD diagnoses and ≥1 transfusion event were included. Rates of transfusion events, SCD complications, and proportion of eligible patients receiving ICT were calculated. ICT eligibility was defined as receiving ≥10 transfusions over lifetime. SCD complications included pain, pulmonary event, infection event, renal, cardiovascular, stroke, leg ulcers, and avascular necrosis. Regressions were used to assess risk factors for transfusion and identify the main drivers of costs.ResultsThe sample included 3,208 patients. The transfusion rate increased from 1‐year‐old to a peak at 16 years old, then dropped until age 26 and remained stable thereafter. In contrast the frequency of diagnoses for SCD complications increased markedly after age 16. Post‐transition patients (≥18 years old) were significantly associated with fewer transfusions (odds ratio: 0.80, P = 0.002). Among eligible patients for ICT, there was no statistically significant difference in total cost between the ICT and no ICT groups (adjusted cost difference, $136, P = 0.114).ConclusionsPatients transitioning to adult care received less transfusions and hydroxyurea, less ICT when eligible for chelation therapy, had higher healthcare costs and suffered from more frequent SCD related complications than pediatric patients. These findings highlight the changes in treatment patterns corresponding to transition to adult care. Pediatr Blood Cancer 2013; 60: 828–835. © 2013 Wiley Periodicals, Inc.
Cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation‐associated dry eye in children
Authors: Hoehn Mary Ellen , Kelly Steven R. , Wilson Matthew W. , Walton R. Christopher 
Published: January 2013

AbstractDry eye disease is a well‐known late complication of radiation therapy and is often difficult to treat. We evaluated the usefulness of cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation‐associated dry eye in children. Eleven children received cyclosporine 0.05% emulsion twice daily after failure of conventional therapy. After 6 months, dry eye manifestations improved in three children (27.3%). The remaining eight children showed no improvement with cyclosporine 0.05% ophthalmic emulsion. These results suggest that twice‐daily cyclosporine 0.05% ophthalmic emulsion has limited use in children with refractory radiation‐associated chronic dry eye. Pediatr Blood Cancer 2013; 60: E35–E37. © 2013 Wiley Periodicals, Inc.
A cyclic selenium‐based reversible addition‐fragmentation chain transfer agent mediated polymerization of vinyl acetate
Authors: Zhan Yiyu , Zhang Zhengbiao , Pan Xiangqiang , Zhu Jian , Zhou Nianchen , Zhu Xiulin 
Published: January 2013

AbstractA cyclic selenium‐based reversible addition‐fragmentation chain transfer (RAFT) agent, 5,5‐dimethyl‐3‐phenyl‐2‐selenoxo‐1,3‐selenazolidin‐4‐one (RAFT‐Se), was synthesized and utilized in the RAFT polymerizations of vinyl acetate (VAc). Its analog, 5,5‐dimethyl‐3‐phenyl‐2‐thioxothiazolidin‐4‐one (RAFT‐S), was also used in RAFT polymerizations for comparison under identical conditions. The RAFT polymerizations of VAc with RAFT‐Se were moderately controlled evidenced by the increase of molecular weights with conversion, despite the slightly high Mw/Mn (less than 1.90), whereas the molecular weights were poorly controlled in the presence of RAFT‐S (2.00 < Mw/Mn < 2.30). Thanks to its unusual cyclic structure of RAFT‐Se, one or more RAFT‐Se species was incorporated into the resultant poly(VAc) as revealed by the results of cleavage of polymer and atomic absorption spectroscopy. Considering the biorelated functions of both poly(VAc) and Se element, this work undoubtedly provided a successful methodology of how to incorporate high content of Se into a molecular weight controlled poly(VAc). © 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland
Authors: Kluźniak Wojciech , Wokołorczyk Dominika , Kashyap Aniruddh , Jakubowska Anna , Gronwald Jacek , Huzarski Tomasz , Byrski Tomasz , Dębniak Tadeusz , Gołąb Adam , Gliniewicz Bartłomiej , Sikorski Andrzej , Świtała Jerzy , Borkowski Tomasz , Borkowski Andrzej , Antczak Andrzej , Wojnar Łukasz , Przybyła Jacek , Sosnowski Marek , Małkiewicz Bartosz , Zdrojowy Romuald , Sikorska‐Radek Paulina , Matych Józef , Wilkosz Jacek , Różański Waldemar , Kiś Jacek , Bar Krzysztof , Bryniarski Piotr , Paradysz Andrzej , Jersak Konrad , Niemirowicz Jerzy , Słupski Piotr , Jarzemski Piotr , Skrzypczyk Michał , Dobruch Jakub , Domagała Paweł , Akbari Mohammad R. , Lubiński Jan , Narod Steven A. , Cybulski Cezary ,   the Polish Hereditary Prostate Cancer Consortium
Published: January 2013

AbstractBACKGROUNDThe G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20‐fold). The geographical and ethnic extent of this recurrent allele has not yet been determined.METHODSWe assayed for the presence of the G84E mutation in 3,515 prostate cancer patients and 2,604 controls from Poland and estimated the odds ratio for prostate cancer associated with the allele.RESULTSThe G84E mutation was detected in 3 of 2,604 (0.1%) individuals from the general population in Poland and in 20 of 3,515 (0.6%) men with prostate cancer (Odds ratio [OR] = 5.0; 95% CI: 1.5–16.7; P = 0.008). The allele was present in 4 of 416 (1.0%) men with familial prostate cancer (OR = 8.4, 95% CI: 1.9–37.7; P = 0.005).CONCLUSIONSThe G84E mutation predisposes to prostate cancer in Poland, but accounts for only a small proportion of cases. We expect that the G84E founder mutation might be present in other Slavic populations. Prostate 73: 542–548, 2013. © 2013 Wiley Periodicals, Inc.
Phase II open label, multi‐center clinical trial of modulation of intermediate endpoint biomarkers by 1α‐hydroxyvitamin D2 in patients with clinically localized prostate cancer and high grade pin
Authors: Gee Jason , Bailey Howard , Kim KyungMann , Kolesar Jill , Havighurst Tom , Tutsch Kendra D. , See William , Cohen Michael B. , Street Nick , LeVan Leon , Jarrard David , Wilding George 
Published: January 2013

AbstractBACKGROUNDProstate cancer is the most common malignancy and second leading cause of cancer related deaths in American men supporting the study of prostate cancer chemoprevention. Major risk factors for this disease have been associated with low serum levels of vitamin D. Here, we evaluate the biologic activity of a less calcemic vitamin D analog 1α‐hydroxyvitamin D2 [1α‐OH‐D2] (Bone Care International, Inc.) in patients with prostate cancer and high grade prostatic intraepithelial neoplasia (HG PIN).METHODSPatients with clinically organ‐confined prostate cancer and HG PIN were randomized to 1α‐OH‐D2 versus placebo for 28 days prior to radical prostatectomy. Intermediate endpoint biomarkers included serum vitamin D metabolites, TGFß 1/2, free/total PSA, IGF‐1, IGFBP‐3, bFGF, and VEGF. Tissue endpoints included histology, MIB‐1 and TUNEL staining, microvessel density and factor VIII staining, androgen receptor and PSA, vitamin D receptor expression and nuclear morphometry.RESULTSThe 1α‐OH‐D2 vitamin D analog was well tolerated and could be safely administered with good compliance and no evidence of hypercalcemia over 28 days. While serum vitamin D metabolite levels only slightly increased, evidence of biologic activity was observed with significant reductions in serum PTH levels. TGF‐ß2 was the only biomarker significantly altered by vitamin D supplementation. Whether reduced TGF‐ß2 levels in our study is an early indicator of response to vitamin D remains unclear.CONCLUSIONSWhile further investigation of vitamin D may be warranted based on preclinical studies, results of the present trial do not appear to justify evaluation of 1α‐OH‐D2 in larger clinical prostate cancer prevention studies. Prostate 73: 970–978, 2013. © 2013 Wiley Periodicals, Inc.
Sensitivity of deep convection to terrain forcing over Mediterranean islands
Authors: Barthlott Christian , Kirshbaum Daniel J. 
Published: January 2013

AbstractThe influence of mountainous islands on the initiation of deep convection is investigated using the Consortium for Small‐scale Modeling (COSMO) model. A case study and sensitivity analysis is performed for 26 August 2009, when moist convection occurred over both Corsica and Sardinia islands in the western Mediterranean Sea. Sensitivity runs with systematically modified topography are explored to evaluate the relative importance of the land–sea contrast and the terrain height for convection initiation. Whereas no island precipitation is simulated when the islands are completely removed, all simulations that represent these land surfaces develop convective precipitation. Although convection initiates progressively earlier in the day over taller islands, the precipitation rates and accumulations do not show a fixed relationship with terrain height. This is due to the competing effects of different physical processes. Firstly, whereas the forcing for low‐level ascent increases over taller islands the boundary‐layer moisture supply decreases, which diminishes the conditional instability and precipitable water. Secondly, whereas taller islands enhance the inland propagation speeds of sea‐breeze fronts they also block these fronts mechanically and prevent them from reaching the island interior. As a result, the island precipitation is rather insensitive to island terrain height except for one particular case in which the island precipitation increases considerably due to an optimal superposition of the sea breeze and upslope flow. Comparing the two islands, convective precipitation develops earlier over Corsica due to its increased terrain height and reduced convective inhibition. However, precipitation amounts are substantially larger over Sardinia, where a stronger land–sea contrast gives rise to a more intense and organized line of sea‐breeze convergence. These results demonstrate the complexity of interactions between sea breezes and orography and reinforce that an adequate representation of detailed topographic features is necessary to account for thermally induced wind systems that initiate deep convection.
Design of a novel class of protein‐based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers
Authors: Xue Shenghui , Qiao Jingjuan , Pu Fan , Cameron Mathew , Yang Jenny J. 
Published: January 2013

AbstractMagnetic resonance imaging (MRI) of disease biomarkers, especially cancer biomarkers, could potentially improve our understanding of the disease and drug activity during preclinical and clinical drug treatment and patient stratification. MRI contrast agents with high relaxivity and targeting capability to tumor biomarkers are highly required. Extensive work has been done to develop MRI contrast agents. However, only a few limited literatures report that protein residues can function as ligands to bind Gd3+ with high binding affinity, selectivity, and relaxivity. In this paper, we focus on reporting our current progress on designing a novel class of protein‐based Gd3+ MRI contrast agents (ProCAs) equipped with several desirable capabilities for in vivo application of MRI of tumor biomarkers. We will first discuss our strategy for improving the relaxivity by a novel protein‐based design. We then discuss the effect of increased relaxivity of ProCAs on improving the detection limits for MRI contrast agent, especially for in vivo application. We will further report our efforts to improve in vivo imaging capability and our achievement in molecular imaging of cancer biomarkers with potential preclinical and clinical applications. WIREs Nanomed Nanobiotechnol 2013, 5:163–179. doi: 10.1002/wnan.1205This article is categorized under:

Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Biology-Inspired Nanomaterials > Peptide-Based Structures
Epidemiology and treatment outcome of congenital pseudarthrosis of the tibia
Authors: Horn Joachim , Steen Harald , Terjesen Terje 
Published: January 2013

Purpose Congenital pseudarthrosis of the tibia (CPT) is a rare disease. Epidemiological data are limited, and treatment of the condition is challenging. The purpose of our study was to gain epidemiological data on the incidence of CPT in Norway and to evaluate the treatment outcome of the disease. Methods During the period 1987–2006 22 patients with CPT were born in Norway (11 boys, 11 girls; mean age 15 years, age range 8–24 years) and are included in this study. During the same time period 1,183,380 live-births were registered by the Norwegian Birth Register. Primary surgical treatment was the Ilizarov method in 15 patients, intramedullary nailing in three patients, and plate osteosynthesis in two patients; two patients never developed a fracture and were treated with an orthosis. Results The incidence of CPT based on this period was 1:53,000. The rate of primary healing was 66 % for the Ilizarov group. Primary healing occurred in three patients treated with intramedullary nailing and in none of the patients treated with plate osteosynthesis. However, almost all patients required additional surgery due to refracture or deformity correction. Currently, all 12 skeletally mature patients are considered to be healed, whereas two of the skeletally immature patients are still under treatment. Conclusion The incidence of CPT in Norway seems to be notably higher than that based on epidemiological data from other studies. Primary healing rates are satisfactory when treated either with an Ilizarov device or intramedullary nailing. Refractures must be avoided, and alignment of the leg must be maintained. Healing is usually achieved before skeletal maturity. However, residual deformities are common.
Post‐conization endocervical curettage for estimating the risk of persistent or recurrent high‐grade dysplasia
Authors: Shaco‐Levy Ruthy , Meirovitz Mihai , Eger Gilad , Benharroch Daniel , Dreiher Jacob 
Published: January 2013

AbstractObjectiveTo evaluate the association between post‐cone endocervical curettage (ECC) results, either alone or with cone margin status, and persistent/recurrent high‐grade dysplasia after conization.MethodsThe medical records of 250 women who underwent a loop electrosurgical excision procedure with post‐cone ECC at Soroka Medical Center, Be'er Sheva, Israel, between January 2001 and July 2011 were reviewed retrospectively.ResultsThirty‐one women (12.4%) had evidence of high‐grade dysplasia in the ECC sample. Factors associated with positive ECC were being older than 35 years (P = 0.004) and positive margin status (P = 0.001). Twenty‐nine patients (11.6%) had persistent/recurrent high‐grade dysplasia. Both high‐grade dysplasia in the ECC sample (hazard ratio, 2.31; P = 0.032) and positive cone margins (hazard ratio, 23.4; P < 0.001) were associated with persistent/recurrent disease.ConclusionHigh‐grade dysplasia in the ECC sample was associated with positive cone margin status. These 2 factors were both associated with persistent/recurrent disease. Among patients with positive cone margins, a combination of margin status and ECC was superior to margin status alone for estimating the probability of persistent/recurrent disease. For women with negative cone margins, ECC was less useful. Because ECC is valuable for assessing the risk of persistent/recurrent high‐grade dysplasia in many cases, post‐cone ECC should be performed routinely with conization.
The consumer psychology of customer–brand relationships: Extending the AA Relationship model
Authors: Schmitt Bernd 
Published: January 2013

AbstractThe Attachment–Aversion (AA) Relationship model offers a unifying model of customer–brand relationships. To develop it further as a relevant consumer‐psychology model, future research should examine three key factors: how brand perception differs from person perceptions; what role brand experiences play as determinants of customer–brand relationships, and how the AA Relationship model fits with other brand frameworks. The author offers insights and suggestions on how to address these three tasks.
Responsiveness of Instruments to Assess Disorders of Consciousness: A Literature Review
Authors: Doig Emmah J. , Lane-Brown Amanda T. 
Published: January 2013

Objectives: To summarise available evidence for responsiveness of six key assessments used with patients with disorders of consciousness: Coma Recovery Scale – Revised (CRS-R), Disorders Of Consciousness Scale (DOCS), Sensory Modality Assessment and Rehabilitation Technique (SMART), Sensory Stimulation Assessment Measure (SSAM), Wessex Head Injury Matrix (WHIM), and the Western Neuro Sensory Stimulation Profile (WNSSP).Method: A literature search of five electronic databases was conducted using a systematic search strategy. Relevant literature was evaluated and pertinent information extracted.Results: Database searches using key terms initially yielded 132 articles. Following review for inclusion identified 24 articles. No studies were specifically designed to investigate responsiveness of any of the measures and therefore responsiveness data were either based on statistical significance of change post-treatment or descriptive analysis of change scores. The majority of studies identified used the CRS-R (n= 11), WHIM (n= 5) and WNSSP (n= 6) and have established responsiveness to change. There is some preliminary evidence for the responsiveness of the other measures, based on very few available studies: DOCS (n= 2), SMART (n= 1) or SSAM (n= 1).Conclusion: Future studies should seek to include responsiveness analysis, particularly in relation to the DOCS, SMART and SSAM.
XVIII.—Les Holothuries de l'Expédition Antarctique Nationale Écossaise
Authors: Vaney Clément 
Published: January 2013

La Scotia a rapporté de son expédition au pôle sud une très importante collection d'Holothuries; nous remercions bien vivement M. W. S. Bruce de l'honueur qu'il nous a fait en nous en confiant l'étude.Cette collection ne renferme pas moins de trente-quatre espèces, dont vingt et une, c'est à dire près des deux tiers, sont nouvelles. Cette proportion aurait été probablement plus grande, mais par suite de l'action de quelques agents conservateurs employés (formaldéhyde et acide acétique glacial) certains échantillons sont indéterminables: leurs corpuscules calcaires ayant été complètement dissous par les liquides acides. Pour la même raison nous avons décrit quelques nouvelles espèces sans pouvoir fournir daus la diagnose les caractères de leurs spicules. Mais la majeure partie des exemplaires et surtout ceux de grandes profondeurs sont en bon état et très bien préparés.
II.—The Moinian and Dalradian Rocks between Glen Roy and the Monadhliath Mountains, Inverness-shire
Authors: Anderson J. G. C. 
Published: January 2013

SynopsisThe paper provides the first detailed geological description of a portion of the Grampian Highlands between Glen Roy in the west and the Monadhliath Mountains in the east. Moinian metasediments comprising thick granulites (Eilde Flags = Central Highland Psammitic Group) followed by a variable series of pelites and impersistent quartzites (Monadhliath Schists = Transition Group) are succeeded by Dalradian Limestone (Kinlochlaggan or Ballachulish Limestone = Basal Calcareous Group). The Monadhliath Schists are shown to be stratigraphically equivalent to those of Lochaber below the Ballachulish Limestone.Structurally the area consists of north-easterly anticlines and synclines which are generally isoclinal and often overturned. Many formational junctions are clearly stratigraphical, but the point is discussed whether tectonic contacts (slides) may also be present. Most of the metasediments are of garnet grade, but in the east there is a poorly-developed kyanite zone, and a well-developed sillimanite zone. The high-grade zones are related to a major migmatite and pegmatite belt (the Strathspey Complex); another pegmatite belt occurs farther west around Loch Laggan. Post-tectonic granite, quartz-diorite, diorite and appinite intrusions are also present. The district is traversed by several important north-easterly faults which are later than both the metasediments and the intrusions.
IV.—The Atrioventricular Pathway for Conduction of the Impulse for Cardiac Contraction in the Dog
Authors: Davies Francis , Francis E. T. B. , Wood D. R. , Johnson E. A. 
Published: January 2013

SynopsisIt is generally believed that in mammals the impulse for cardiac contraction is conveyed from the atria to the ventricles by the atrioventricular bundle and its branches. This belief is mainly based on the A-V. dissociation which is found to follow experimental injury of the bundle. Since the bundle contains nerves, as well as specialized muscular elements, these experiments do not conclusively prove which structures, nerves or muscle, actually conduct the impulse. In the dog it has been previously shown that the right limb of the bundle is not usually accompanied by nerves, and in the present work the attempt was made by means of very small incisions to cut the muscle (Purkinje) fibres of the limb without damaging nerves in the ventricular septum, the effect on the electrocardiogram being noted. In 5 out of 38 perfused hearts of dogs the experiment was successful, and resulted in a significant delay in the contraction of the right ventricle relative to that of the left. The experiments also revealed that very considerable damage can be inflicted on the nerves in the ventricular septum without altering the electrocardiogram, so long as the limb itself is not injured. The results are regarded as providing direct evidence that the cardiac impulse in the dog is transmitted to the right ventricle by the muscular elements of the right limb of the bundle, and it is submitted that there would seem to be no valid reason for supposing that conduction throughout the A-V. bundle and its limbs is other than myogenic.
IX.—The Vascular Architecture of the Rat Uterus during Pregnancy
Authors: Young A. 
Published: January 2013

SynopsisThe changes in the vascular pattern of the pregnant rat uterus at placental sites and the intervening areas, have been studied radiologically and by injection techniques during the period of pregnancy. A description is given of the development and final pattern of the maternal placental blood channels. From the 15th day onwards wide variations are found in the vascular filling of placentæ after arterial injection. Possible mechanisms for the control of blood flow to placental sites are discussed.
XXIII.—The Life Histories and Ecology of Two Species ofPetrobiusLeach,P. brevistylisandP. maritimus
Authors: Delany M. J. 
Published: January 2013

SynopsisThe life history ofPetrobius brevistylisCarpenter is described from material reared in the laboratory and captured in the field (south Devonshire). A method of identifying the first eight instars is discussed and their diagnostic morphological characters described. Fecundity and time of oviposition are considered at some length. The effects of climate on various phases of the life history are considered as well as the faunas found associated withP. brevistylis. A brief description of the life history ofP. maritimus(Leach) is included.