bluuebunny/crossref_metadata_2025_split huggingface dataset:
Redefining a new frontier in alkaptonuria therapy with AI-driven drug candidate design via in-
silico innovation
Authors: Naveed Muhammad , Javed Khushbakht , Aziz Tariq , Zafar Ali , Fatima Mahnoor , Ali Imran , Khan Ayaz Ali , Albekairi Thamer H. 
Published: July 2024

Abstract
A rare metabolic condition called alkaptonuria (AKU) is caused by a decrease in homogentisate 1,2 dioxygenase (HGO) activity due to a mutation in homogentisate dioxygenase (HGD) gene. Homogentisic acid is a byproduct of the catabolism of tyrosine and phenylalanine that darkens the urine and accumulates in connective tissues which causes an agonizing arthritis. Employing the use of deep learning artificial intelligence (AI) drug design, this study aims to alleviate the current toxicity of the AKU drugs currently in use, particularly nitisinone, by utilizing the natural flavanol kaempferol molecule as a 4-hydroxyphenylpyruvate dioxygenase inhibitor. Kaempferol was employed to generate three effective de novo drug candidates targeting the enzyme 4-hydroxyphenylpyruvate dioxygenase using an AI drug design tool. We present novel AIK formulations in the present study. The AIK’s (Artificial Intelligence Kaempferol) examination of drug-likeliness among the three led to its choice as a possible target. The toxicity assessment research of AIK demonstrates that it is not only safer to use than other treatments, but also more efficient. The docking of the AIGT with 4-hydroxyphenylpyruvate dioxygenase, which revealed a binding affinity of around −9.099 kcal/mol, highlights the AIK’s potential as a therapeutic candidate. An innovative approach to deal with challenging circumstances is thus presented in this study by new formulations kaempferol that have been meticulously designed by AI. The results of the in vitro tests must be confirmed in vivo, even though AI-designed AIK is effective and sufficiently safe as computed.
Influence of Fibrous Layers on the Behavior of Self-Compacting Lightweight Reinforced Concrete Slabs under Area Load
Authors: Al-Ridha Ahmed S. D. , Atshan Ali F. , Kadhim Ibrahim Ali , Abbood Ali A. , Sahib Dheyab Layth 
Published: July 2024

Abstract
The current research studies the effectiveness of steel fibrous layers on the performance of self-compacting lightweight reinforced concrete two-way slabs with (length/width) ratio ≈ 1.618 (golden ratio). In this work, steel fibers (SFs) have been added to four slab specimens with volume fractions of 0.4 % and 0.8 %, in one bottom layer and two top and bottom layers, in addition to a reference slab without SFs, the four slabs were tested under uniform load. The results revealed that when using single or dual fibrous layers, the flexural strength of slabs was considerably enlarged (numerically 41.3 % for single bottom layer and 72.4 % for both top and bottom layers when using 0.4 % SF, and 113.7 % for a single bottom layer and 193 % for both top and bottom layers when using 0.8 % SF) as compared with nonfibrous slabs, and the failure mode had altered from flexure mode to shear one as compared with nonfibrous slabs. The effect of these fibrous layers was enlarged with increasing the content of SF. And for the same amount of SF, the influence of SF is greater when it is distributed in one bottom layer (numerically 113.7 %) than when distributed in two layers (numerically 41.3 %).
Stabilization Tests for Deep Mixing—Round-Robin Tests in Eight Finnish Laboratories
Authors: Forsman Juha , Ikävalko Jari , Löfman Monica , Korkiala-Tanttu Leena , Teittinen Tuuli 
Published: July 2024

Abstract
Stabilization tests in laboratory play an essential part of quality control and assurance of the deep mixing method. By preparing and testing laboratory soil specimens stabilized with different binder types and dosages (binder recipes), estimation of in-situ properties of treated soil can be made. The stabilization tests typically consist of uniaxial compressive tests of cylindrical specimens. However, there have not been any national guidelines in Finland on laboratory methods for stabilization tests until year 2018, when an updated Finnish stabilization design guideline was published by the Finnish Transport Agency. By means of this guideline, stabilization test results from different laboratories should be comparable. To study the comparability of the stabilization tests from different laboratories, a round-robin study (interlaboratory test) between laboratories was completed. The performed stabilization test series have been examined as the internal (within laboratory) coefficient of variation of the individual test series and as the external variation of the parallel stabilization test series performed in different laboratories. The internal variation of the stabilization test series was modest in most of the laboratories, but regardless of the national stabilization test guideline, a large variation was found in the results of the parallel test series of the laboratories. Based on the findings, additions to the Finnish national guidelines are needed and these additions are planned for implementation during 2023–2024.
Ativismo judicial: vontade de poder ou vontade de constituição? Uma leitura do instituto à luz do diálogo Hesse-Lassale
Authors: Jacintho Jussara Maria Moreno , Maia Eduardo Gomes Ribeiro 
Published: July 2024

Resumo: O presente artigo tem por objetivo estudar os efeitos do ativismo judicial sobre a atual interpretação constitucional à luz das principais obras de Konrad Hesse e Ferdinand Lassale, a fim de compreender se as diversas alterações – não só interpretativas como também materiais, através das Emendas Constitucionais – estão sendo promovidas pelos fatores reais de poder ou se possuem o escopo de preservar a força normativa da Carta constitucional. Dessa forma, tal estudo é de grande importância, uma vez que contribui para a inarredável vigilância da Carta Constitucional de 1988, bem como para a compreensão das recentes viradas interpretativas conferidas pela Corte Suprema.Palavras-chave: Ativismo judicial. Constituição. Interpretação. Força normativa. Abstract: This article aims to study the effects of the judicial activism on the current constitutional interpretation in light of the main works of Konrad Hesse and Ferdinand Lassale, in order to understand if the different changes - not only interpretive ones but also substantial ones, through Constitutional Amendments - are being provided by the real factors of power or if they have the scope of preserving the normative force of Constitutional Charter. In this way, the present study is relevant, as it has the vision to contribute to a permanent inspection of the Constitutional Charter, as well as to the understanding the last interpretive turns conferred by the Supreme Court.Keywords: Judicial activism. Constitution. Interpretation. Normative force. Sumário: Introdução. 1. Breves Considerações Acerca do Ativismo Judicial. 2. Uma Carta Política com Excesso de Emendas. 3. Ativismo Judicial como Vontade de Constituição ou Vontade de Poder. Considerações Finais. Referências.
INCORPORATING RELIGIOUS MODERATION VALUES INTO ENGLISH LANGUAGE TEACHING: A PORTRAIT OF AN INDONESIAN VOCATIONAL SCHOOL
Authors: Wahyuningsih Sri , Munawaroh Anisa 
Published: July 2024

ABSTRACTThe present study explores the process of instilling religious moderation values in English teaching at an Indonesian vocational school. Furthermore, challenges in instilling religious moderation values and solutions are discussed. The qualitative case study method was used in this study. Data were gathered through observation, semi-structured interviews with two English language teachers and two students at an Indonesian vocational school, and documentation. The findings reveal that internalization of religious moderation values can be incorporated through verbal stimulation (reminders and advice), English material, teaching methods, teachers' behavior, and assignments. These values include tolerance, discussion, justice, dynamics, creativity, and innovation. Meanwhile, challenges include students' personality differences and a lack of English textbooks containing religious moderation values. Several strategies were used to tackle the obstacles, including motivating students to participate actively in the teaching and learning process and exploring English material dealing with religious moderation. The implication of the study was discussed. ABSTRAKPenelitian ini bertujuan untuk mengeksplorasi proses penanaman nilai-nilai moderasi beragama dalam pengajaran bahasa Inggris di sekolah menengah kejuruan (SMK) di Indonesia. Selanjutnya, tantangan yang dihadapi guru bahasa Inggris dalam menanamkan nilai-nilai moderasi beragama, dan solusinya juga dibahas. Metode studi kasus kualitatif digunakan dalam penelitian ini. Data dikumpulkan melalui observasi, wawancara semi terstruktur dengan dua guru bahasa Inggris dan dua siswa SMK di Indonesia, dan dokumentasi. Hasil temuan menunjukkan bahwa internalisasi nilai moderasi beragama dapat diwujudkan melalui stimulasi verbal (pengingat dan nasihat), materi bahasa Inggris, metode pengajaran, perilaku guru, dan penugasan. Nilai-nilai tersebut antara lain toleransi, diskusi, keadilan, dinamika, kreativitas, dan inovasi. Guru bahasa Inggris menghadapi tantangan karena perbedaan kepribadian siswa dan terbatasnya sumber atau materi bahasa Inggris yang mengandung nilai-nilai moderasi agama. Adapun beberapa strategi yang digunakan guru untuk mengatasi kendala tersebut antara lain memotivasi siswa untuk berpartisipasi aktif dalam proses belajar mengajar dan mengeksplorasi materi bahasa Inggris yang berhubungan dengan moderasi agama. Implikasi dari temuan dibahas dalam penelitian ini.How to Cite: Wahyuningsih, S. & Munawaroh, A. (2023). Incorporating Religious Moderation Values into English Language Teaching: A Portrait of an Indonesian Vocational School. IJEE (Indonesian Journal of English Education), 10(2), 409-427. doi:10.15408/ijee.v10i2.28946.
Pannonian women's headwear-related accessories
Authors: Sáró Csilla 
Published: July 2024

AbstractThe main goal of this paper is to study a specific element of women's depicted costumes. Pictures on stone monuments present local, so-called native women wearing complex attire of cloth, headwear, brooches, jewels, and other dress accessories. Thirteen stone monuments from Hungary depict local women with headwear-related accessories. The main questions are: what kind of accessories are they, and how can we evaluate their presence on depicted attires? I collected analogous depictions from other Provinces and studied archaeological material. Finally, I concluded that these headwear-related accessories connect to new cultural effects and the complex phenomenon of acculturation.
Academic Dishonesty in College Students: Do Religiosity and Self-Control Matter?
Authors: Uula Alfi Hanifatul , Sulikah Sulikah 
Published: July 2024

Academic dishonesty among students in numerous nations is on the rise, and if allowed unchecked, it may be hazardous to a person's personality development and even entry into the workforce. The purpose of this study is to investigate the impact of religiousity and self-control on academic dishonesty in Accounting Education students at the State University of Malang. The purposive sampling strategy yielded a total of 96 samples. The data was gathered using an online questionnaire and analyzed using multiple linear regression in a data processing tool (SPSS). According to the findings of the study, religiousity and self-control had a detrimental impact on student academic dishonesty. This suggests that the higher a student's level of religiousity and self-control, the less academic dishonesty he or she commits, and vice versa.
Pengaruh Manajemen Sarana Dan Prasarana Terhadap Mutu Pendidikan
Authors: Makarau Nur Istiana , Wulandari Heny , Na'imah Na'imah , Aprida Siti Nurul 
Published: July 2024

Abstract: Facilities and infrastructure are devices in organizing and managing school activities in order to achieve a goal. Therefore, the management of facilities and infrastructure is a way to achieve the function of facilities and infrastructure to be effective and efficient. The purpose of this study was to determine the effect of facilities and infrastructure on the quality of education in Mutiara Nambo Bosa Kindergarten, Banggai Regency. This type of research uses quantitative research with simple linear regression test data analysis and instruments in the form of a questionnaire. The sample of this study amounted to 5 people consisting of the principal and all teachers at Mutiara Nambo Bosaa Kindergarten. The results showed that the management of facilities and infrastructure had a positive and significant effect on the quality of education in Mutiara Nambo Bosaa Kindergarten, Banggai Regency, namely the significance value was 0.042 <0.05 and it means Ha is accepted and H0 is rejected. The coefficient of determination (R2) was obtained 0.795 which can be said to have a positive significance with a high interpretation, and a value of 0.795 or 79.5% which implies that the influence of Facilities and Infrastructure Management on Education Quality is 79.5%, and the remaining 20.5% is influenced by by another variable.Keywords: Management, facilities and infrastructure, quality of education Abstrak: Sarana dan prasarana adalah perangkat dalam menyelenggarakan dan mengelola kegiatan sekolah demi mencapai suatu tujuan. Maka dari itu, manajemen sarana dan prasarana menjadi jalan untuk mencapai fungsi sarana dan prasarana menjadi efektif dan efisien. Tujuan pada penelitian ini adalah mengetahui pengaruh sarana dan prasarana terhadap mutu pendidikan di TK Mutiara Nambo Bosaa Kabupaten Banggai. Jenis penelitian ini menggunakan penelitian kuantitatif dengan analisis data uji regresi linear sederhana dan instrument yang berpa kuesioner. Sampel penelitian ini berjumlah 5 orang yang terdiri dari kepala sekolah dan seluruh guru di TK Mutiara Nambo Bosaa. Hasil penelitian menunjukkan manajemen sarana dan prasarana berpengaruh positif dan signifikan terhadap mutu pendidikan di TK Mutiara Nambo Bosaa Kabupaten Banggai yaitu nilai signifikansinya 0,042 < 0,05 dan berarti Ha diterima dan H0 ditolak. Koefisien determinasi (R2)didapatkan 0,795 yang dapat dikatakan terdapat signifikansi positif dengan interpretasi tinggi, dan nilai 0,795 atau 79,5% yang mengandung pengertian bahwa pengaruh Manajemen Sarana dan Prasarana terhadap Mutu Pendidikan sebesar 79,5%, dan sisanya 20,5% dipengaruhi oleh variable lain.Kata Kunci: Manajemen, sarana dan prasarana, mutu pendidikan
Peran Kepala Sekolah dalam Implementasi Supervisi Pembelajaran untuk Mengingkatkan Kualitas Guru di Abad 21
Authors: Sahirah Nahdah Nasya , Suryana Asep , Sutarsih Cicih , Nurdin Diding 
Published: July 2024

Abstract: This research aims to describe and analyze the role of the principal in the implementation of learning supervision to improve the quality of teachers in the 21st century at SD Mutiara Bunda, Bandung City. The method used in this research is descriptive qualitative with data collection techniques through observation, interviews, and documentation. The results of the study show that the principal plays a role in the implementation of learning supervision at SD Mutiara, assisted by the school’s academic team by integrating formal and informal approaches. The techniques used by the principal in learning supervision are direct and indirect observation. The principal plays a role in 4 cycles of learning supervision implementation, namely planning, implementation, evaluation, and follow-up. In the implementation cycle, it is carried out in 4 stages, namely learning planning, learning implementation, learning evaluation, and learning follow-up. The follow-up carried out by the principal is by holding workshops and individual coaching for teachers. The implementation of learning supervision carried out by the principal is by 21st-century supervision, which emphasizes guidance for teachers to improve teacher quality.Keyword: Supervision, learning supervision, 21st century. Abstrak: Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis peran kepala sekolah dalam implementasi supervisi pembelajaran untuk meningkatkan kualitas guru abad 21 di SD Mutiara Bunda Kota Bandung. Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif dengan teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa kepala sekolah berperan dalam implementasi supervisi pembelajaran di SD Mutiara dibantu oleh tim akademik sekolah dengan mengintegrasikan pendekatan formal dan informal, teknik yang digunakan kepala sekolah dalam supervisi pembelajaran adalah observasi secara langsung dan tidak langsung. Kepala sekolah berperan dalam 4 siklus implementasi supervisi pembelajaran yaitu perencanaan, pelaksanaan, evaluasi dan tindak lanjut. Dalam siklus pelaksanaan dilakukan dalam 4 tahapan pula yaitu perencanaan pembelajaran, pelaksanaan pembelajaran, evaluasi pembelajaran, dan tindak lanjut pembelajaran. Tindak lanjut yang dilakukan oleh kepala sekolah yaitu dengan mengadakan workshop dan coacing individual kepada guru. Implementasi supervisi pembelajaran yang dilakukan oleh kepala sekolah telah sesuai dengan supervisi abad 21 yaitu dengan menekankan pembinaan kepada guru untuk meningkatkan kualitas guru.Kata kunci: Supervisi, supervisi pembelajaran, abad 21
The influence of the guided inquiry method and critical thinking on the learning outcomes of culinary arts in class X high school students
Authors: Gunawan Wawan , Karyanto Yunus , Wiyarno Yoso , Atiqoh Atiqoh , Suharti Suharti , Harwanto Harwanto 
Published: July 2024

Abstrak: Pembelajaran yang memberikan pengalaman dan partisipasi siswa adalah pembelajaran inkuiri karena pembelajaran inkuiri menuntut siswa untuk melakukan aktivitas, mengamati, menganalisis, dan menarik kesimpulan dari aktivitas yang diamati. Artinya metode inkuiri dapat mengembangkan kemampuan berpikir siswa sehingga menuntut siswa untuk mengambil inisiatif dalam memecahkan masalah. Tujuan dari penelitian ini adalah untuk mengetahui ada pengaruh hasil belajar tata boga antara yang menggunakan metode guided inquiry dan metode ekspositori, pada siswa yang mempunyai kemampuan berpikir kritis berbeda. Penelitian ini menggunakan rancangan kuasi eksperimental faktorial 2X2. Hasil penelitian ini dapat ditarik simpulan sebagai berikut: Ada perbedaan hasil belajar tata boga siswa yang memiliki kemampuan berpikir kritis tinggi dengan kemampuan berpikir kritis rendah dan ada interaksi antara penerapan metode guided inquiry dan kemampuan berpikir kritis terhadap hasil belajar tata boga siswa. Berdasarkan temuan penelitian dapat disimpulkan bahwa penggunaan metode guided inquiry dan keterampilan berpikir kritis dapat meningkatkan hasil belajar tata boga pada siswa SMA Kelas X.Abstract: Learning that provides student experience and participation is inquiry learning because inquiry learning requires students to carry out activities, observe, analyze and draw interesting conclusions from the activities observed. This means that the inquiry method can develop students' thinking abilities so that it requires students to take the initiative in solving problems. The aim of this research is to determine whether there is an influence on culinary learning outcomes between those using the guided inquiry method and the expository method, on students who have different critical thinking abilities. This research uses a 2X2 factorial quasi-experimental design. The following conclusions can be drawn from the results of this research: There are differences in the culinary learning outcomes of students who have high critical thinking abilities and those with low critical thinking abilities and there is an interaction between the application of the guided inquiry method and critical thinking abilities on students' culinary cooking learning outcomes. Based on research findings, it can be concluded that the use of guided inquiry methods and critical thinking skills can improve culinary learning outcomes in Class X high school students.
Successful Management by Posterior Approach Only of a Highly Comminuted L4 Fracture with 8 years of Follow-up
Authors: Mehdian Hossein , Pasku Dritan , Najjar Elie , Quraishi Nasir A. 
Published: July 2024

Case:
A 28-year old male patient was involved in a RTA and sustained a highly comminuted L4 burst fracture with more than 90% canal compromise.
Considering the complete loss of power in the respective myotomes but the preservation of sacral sparing there were controversially different surgical options. We successfully performed a posterior only surgical procedure, which applied a modified transpedicle access technique to decompress the spinal canal and to restore the anterior column, achieving full neurological recovery at the final follow-up.

Conclusion:
A well-planned and executed posterior surgery alone can achieve excellent clinical and radiological result in the treatment of severely comminuted lumbar fractures.
Single-Position Synchronal Management of Metastatic Prostate Cancer of the Spine and Femur Using Prone Nailing
Authors: Dow Robert , Gronowicz Scott , Aceto Matthew , Daniels Alan , Diebo Bassel , Chiappetta Gino , Haque Maahir 
Published: July 2024

Case:
A 71-year-old man with castration-resistant Stage IVB prostate cancer developed symptomatic oligometastatic disease in the lumbar spine and bilateral proximal femurs. He was treated with a single-position L2-L4 kyphoplasty with concomitant prone left-sided femoral prophylactic cephalomedullary nailing. Six months later when he again lost the ability to ambulate, he was treated with a single-position L4-L5 laminectomy for an epidural tumor with prone right-sided femoral prophylactic cephalomedullary nailing.

Conclusion:
Single-position prone surgery of the spine and prone femoral nailing is feasible and improves on traditional multiposition approaches, eliminating the need to reposition or change tables during management.
Defining and Differentiating Congenital Vertical Talus and Congenital Oblique Talus
Authors: Mosca Vincent S. , Ganjwala Dhiren , Shah Hitesh 
Published: July 2024

Background:
Congenital vertical talus (CVT) and congenital oblique talus (COT) are rocker-bottom foot deformities that have similar names and no objective definitions. This has led to confusion for practitioners, as well as scientific challenges for researchers. Our goal was to provide objective radiographic criteria to define and differentiate CVT and COT.

Methods:
We evaluated 62 pairs of maximum dorsiflexion and plantar flexion lateral radiographs of infant feet that had been clinically diagnosed with CVT. The dorsiflexion tibiotalar angle, the plantar flexion talus-first metatarsal angle, and the plantar flexion foot center of rotation of angulation (foot-CORA) were measured using transparent overlay tools. Freehand measurements were made on a subset of 10 pairs of radiographs to confirm clinical applicability. Nine contralateral pairs of radiographs of normal feet were measured for comparison.

Results:
Specific values for the radiographic measurements were identified that, together, reliably differentiated the shapes of rocker-bottom feet with CVT, COT, and flexible flatfoot with a short tendo-Achilles (FFF-STA), as well as the shape of the normal foot. More severe and rigid rocker-bottom foot deformities were diagnosed with CVT. Less severe and more flexible deformities were diagnosed with COT.

Conclusions:
CVT, COT, FFF-STA, and normal feet can be reliably differentiated using 2 angular measurements and 1 bone position measurement on dorsiflexion and plantar flexion lateral radiographs. Our data indicated that the differentiation of CVT and COT is based primarily on the rigidity of the navicular dislocation rather than the verticality of the talus. The data further supported the proposition that COT is a foot deformity along a spectrum of valgus/eversion deformities of the hindfoot that requires early treatment. Application of these diagnostic criteria should lead to clinical studies that identify a specific treatment, treatment outcome, and prognosis for each deformity.

Level of Evidence:
Diagnostic Level II. See Instructions for Authors for a complete description of levels of evidence.