bluuebunny/crossref_metadata_2025_split huggingface dataset:
KPI information acquisition by analysts: Evidence from conference calls
Authors: Tang Qi Rachel , Huang Alan Guoming 
Published: July 2024

AbstractInvestors are increasingly placing reliance on alternative performance measures (APMs). Key performance indicators (KPIs) are a subset of these APMs that illustrate industry‐specific firm financial and operational performance. In this study, we investigate analysts’ demand for KPI‐related information in earnings conference calls and whether managers adjust their decisions about voluntary KPI disclosure in subsequent earnings calls. Using 51 KPIs for six industries, we find that after analysts request KPI‐related information, managers increase both the likelihood and intensity of their KPI disclosure in subsequent earnings conference calls. This effect is more pronounced when the firm has less relevant earnings and lower proprietary costs, and when analysts are connected to management. Analyst KPI demand leads to a higher coverage of KPIs in subsequent news and generates benefits in analyst forecast dispersion, cost of capital and stock liquidity. Our study highlights the role that analysts play in voluntary KPI disclosure when there is an absence of mandatory integrated reporting.
The bottom‐up approach in multigenerational family therapy: The child as the family guide
Authors: Andolfi Maurizio 
Published: July 2024

AbstractIn therapy, the child is mainly seen as a problem to be labeled or as a victim of various forms of abuse. The idea of the child as a therapeutic resource is the central point of my article where children's symptoms are quickly reframed and get a relational meaning in the family. Once the relational competence of the child is appreciated and his voice is heard, the child becomes a special guide to explore the emotional world of his family, and the genogram can provide a wonderful platform to start this therapeutic journey. Using a multigenerational lens, I describe how to explore family development with a “bottom‐up approach.” Intergenerational questions can be asked to the child and with his help relevant family events can emerge and broken bonds repaired. The therapeutic results I expect are the resolution of children's problems and family transformation.
Initial findings using high‐resolution magnetic resonance imaging for visualisation of the sural nerve and surrounding anatomy in healthy volunteers at 7 Tesla
Authors: McDowell Amy R. , Zambreanu Laura , Salhab Hamza A. , Doherty Carolynne M. , Bridgen Philippa , Lally Pete , Shah Sachit , Huo Zimu , Wastling Stephen J. , Yousry Tarek , Morrow Jasper , Thornton John S. , Lunn Michael P. 
Published: July 2024

AbstractBackground and AimsHistopathological diagnosis is the gold standard in many acquired inflammatory, infiltrative and amyloid based peripheral nerve diseases and a sensory nerve biopsy of sural or superficial peroneal nerve is favoured where a biopsy is deemed necessary. The ability to determine nerve pathology by high‐resolution imaging techniques resolving anatomy and imaging characteristics might improve diagnosis and obviate the need for biopsy in some. The sural nerve is anatomically variable and occasionally adjacent vessels can be sent for analysis in error. Knowing the exact position and relationships of the nerve prior to surgery could be clinically useful and thus reliably resolving nerve position has some utility.Methods7T images of eight healthy volunteers' (HV) right ankle were acquired in a pilot study using a double‐echo in steady‐state sequence for high‐resolution anatomy images. Magnetic Transfer Ratio images were acquired of the same area. Systematic scoring of the sural, tibial and deep peroneal nerve around the surgical landmark 7 cm from the lateral malleolus was performed (number of fascicles, area in voxels and mm2, diameter and location relative to nearby vessels and muscles).ResultsThe sural and tibial nerves were visualised in the high‐resolution double‐echo in steady‐state (DESS) image in all HV. The deep peroneal nerve was not always visualised at level of interest. The MTR values were tightly grouped except in the sural nerve where the nerve was not visualised in two HV. The sural nerve location was found to be variable (e.g., lateral or medial to, or crossing behind, or found positioned directly posterior to the saphenous vein).InterpretationHigh‐resolution high‐field images have excellent visualisation of the sural nerve and would give surgeons prior knowledge of the position before surgery. Basic imaging characteristics of the sural nerve can be acquired, but more detailed imaging characteristics are not easily evaluable in the very small sural and further developments and specific studies are required for any diagnostic utility at 7T.
Mental Health Promotion in Hong Kong: A Service Evaluation of the Coolminds Pilot Study
Authors: Thiang Odile , Ho Grace W.K. , Chiu Jonie , Lee Nicole , Hsu Sarah G. 
Published: July 2024

ABSTRACTBACKGROUNDIt is vital to improve the mental health (MH) of young people in Hong Kong, where the suicide rate has nearly doubled among those aged 15‐29 years since 2014. This multi‐method evaluation aimed to assess Coolminds, which promoted MH literacy by engaging students, parents, and educators in secondary schools in Hong Kong.METHODSStudents, parents, and teachers completed self‐report measures before and after attending workshops aimed at raising MH literacy. Pre‐ and post‐survey data were collected between November 2021 and August 2022. Qualitative data from participant feedback and a focus group interview with Coolminds staff were analyzed using descriptive content analysis.RESULTSThe final dataset included 2903 students, 395 parents, and 325 educators from 52 schools. Only 3 schools had engagement with all 3 key groups. Significant improvements in MH knowledge were observed after the Coolminds workshops for all 3 groups. Qualitative analysis identified a reactive approach to MH issues, and bureaucratic and logistical challenges as barriers to implementation.CONCLUSIONFindings support the effectiveness of the Coolminds curriculum in improving MH literacy for each group and the demand for MH promotions in school settings. The implementation challenges indicate the need for future initiatives to better align with local needs and practices.
Dysregulation of the Suprachiasmatic Nucleus Disturbs the Circadian Rhythm and Aggravates Epileptic Seizures by Inducing Hippocampal GABAergic Dysfunction in C57BL/6 Mice
Authors: Liang Xiaoshan , Liang Xiaotao , Zhao Yunyan , Ding Yuewen , Zhu Xiaoyu , Zhou Jieli , Qiu Jing , Shen Xiaoqin , Xie Wei 
Published: July 2024

ABSTRACTThe interplay between circadian rhythms and epilepsy has gained increasing attention. The suprachiasmatic nucleus (SCN), which acts as the master circadian pacemaker, regulates physiological and behavioral rhythms through its complex neural networks. However, the exact role of the SCN and its Bmal1 gene in the development of epilepsy remains unclear. In this study, we utilized a lithium–pilocarpine model to induce epilepsy in mice and simulated circadian disturbances by creating lesions in the SCN and specifically knocking out the Bmal1 gene in the SCN neurons. We observed that the pilocarpine‐induced epileptic mice experienced increased daytime seizure frequency, irregular oscillations in core body temperature, and circadian gene alterations in both the SCN and the hippocampus. Additionally, there was enhanced activation of GABAergic projections from the SCN to the hippocampus. Notably, SCN lesions intensified seizure activity, concomitant with hippocampal neuronal damage and GABAergic signaling impairment. Further analyses using the Gene Expression Omnibus database and gene set enrichment analysis indicated reduced Bmal1 expression in patients with medial temporal lobe epilepsy, potentially affecting GABA receptor pathways. Targeted deletion of Bmal1 in SCN neurons exacerbated seizures and pathology in epilepsy, as well as diminished hippocampal GABAergic efficacy. These results underscore the crucial role of the SCN in modulating circadian rhythms and GABAergic function in the hippocampus, aggravating the severity of seizures. This study provides significant insights into how circadian rhythm disturbances can influence neuronal dysfunction and epilepsy, highlighting the therapeutic potential of targeting SCN and the Bmal1 gene within it in epilepsy management.
Who works with whom? Collaboration ties in legislative policy‐making networks
Authors: Häge Frank M. , Ringe Nils 
Published: July 2024

AbstractSocial relations have the potential to shape who assumes policy leadership positions in legislative politics. Applying a relational event modeling framework, this paper investigates if homophily and reciprocity predict patterns of collaboration between lawmakers as they negotiate proposed legislation. Specifically, it examines if members of the European Parliament (EP) who serve as rapporteurs or shadow rapporteurs are more likely to select into working with colleagues who share their personal attributes or with whom they have previously collaborated. It conceives of EP policy‐making as an evolving two‐mode network comprised of legislators and jointly produced policy documents as nodes, and (shadow‐) rapporteurships as ties. Conditional logistic regression analyses confirm that previous collaboration, shared native language and gender, as well as policy expertise, increase the likelihood of MEPs becoming (shadow‐)rapporteurs. In contrast, party loyalty shows no clear, unambiguous effect.
Fixation Disparity: A Possible Index of Visuospatial Cognition during Authentic Learning Tasks
Authors: Koh Do Hyong , Xu Zhen , Wang Jiahui , Burgess Andrea N. , Seccia Amanda , Schneps Matthew , Pomplun Marc , Lamb Richard , Keil Andreas , Dawson Kara , Antonenko Pavlo 
Published: July 2024

AbstractThis article describes a novel method for quantifying fixation disparity and evaluates its role in visuospatial cognition during an authentic learning task, specifically, the determination of molecule chirality in organic chemistry involving mental rotation and pattern comparison. The first study examined the influence of molecular model dimensionality (2D vs. 3D) on chirality determination performance and visual attention of 55 participants. The second study explored how the sustained playing of the tile‐matching game Mahjong, a pattern comparison game, can affect visual attention and visuospatial performance during the chirality determination task of 59 participants. Fixation disparity was one of the eye tracking variables explored. Both studies revealed that (1) individuals with higher fixation disparity underperformed on the chirality task, which involves mental rotation and pattern comparison, and (2) fixation disparity improved over time in participants who played Mahjong. This work provides important implications for using fixation disparity as a possible biomarker of visuospatial performance.
Contrasting and conserved roles of NPR pathways in diverged land plant lineages
Authors: Jeon Hyung‐Woo , Iwakawa Hidekazu , Naramoto Satoshi , Herrfurth Cornelia , Gutsche Nora , Schlüter Titus , Kyozuka Junko , Miyauchi Shingo , Feussner Ivo , Zachgo Sabine , Nakagami Hirofumi 
Published: July 2024

Summary

The NPR proteins function as salicylic acid (SA) receptors in Arabidopsis thaliana. AtNPR1 plays a central role in SA‐induced transcriptional reprogramming whereby positively regulates SA‐mediated defense. NPRs are found in the genomes of nearly all land plants. However, we know little about the molecular functions and physiological roles of NPRs in most plant species.

We conducted phylogenetic and alignment analyses of NPRs from 68 species covering the significant lineages of land plants. To investigate NPR functions in bryophyte lineages, we generated and characterized NPR loss‐of‐function mutants in the liverwort Marchantia polymorpha.

Brassicaceae NPR1‐like proteins have characteristically gained or lost functional residues identified in AtNPRs, pointing to the possibility of a unique evolutionary trajectory for the Brassicaceae NPR1‐like proteins. We find that the only NPR in M. polymorpha, MpNPR, is not the master regulator of SA‐induced transcriptional reprogramming and negatively regulates bacterial resistance in this species. The Mpnpr transcriptome suggested roles of MpNPR in heat and far‐red light responses. We identify both Mpnpr and Atnpr1‐1 display enhanced thermomorphogenesis. Interspecies complementation analysis indicated that the molecular properties of AtNPR1 and MpNPR are partially conserved. We further show that MpNPR has SA‐binding activity.

NPRs and NPR‐associated pathways have evolved distinctively in diverged land plant lineages to cope with different terrestrial environments.
Dynamic m6A mRNA methylation reveals the involvement of AcALKBH10 in ripening‐related quality regulation in kiwifruit
Authors: Su Dan , Shu Peng , Hu Nan , Chen Yuan , Wu Yi , Deng Heng , Du Xiaofei , Zhang Xumeng , Wang Ruochen , Li Huajia , Zeng Yunliu , Li Dawei , Xie Yue , Li Mingzhang , Hong Yiguo , Liu Kaidong , Liu Mingchun 
Published: July 2024

Summary

Kiwifruit ripening is a complex and highly coordinated process that occurs in conjunction with the formation of fruit edible quality. The significance of epigenetic changes, particularly the impact of N6‐methyladenosine (m6A) RNA modification on fruit ripening and quality formation, has been largely overlooked.

We monitored m6A levels and gene expression changes in kiwifruit at four different stages using LC‐MS/MS, MeRIP, RNA‐seq, and validated the function of AcALKBH10 through heterologous transgenic expression in tomato.

Notable m6A modifications occurred predominantly at the stop codons and the 3′ UTRs and exhibited a gradual reduction in m6A levels during the fruit ripening process. Moreover, these m6A modifications in the aforementioned sites demonstrated a discernible inverse relationship with the levels of mRNA abundance throughout the ripening process, suggesting a repression effect of m6A modification in the modulation of kiwifruit ripening.

We further demonstrated that AcALKBH10 rather than AcECT9 predominantly regulates m6A levels in ripening‐related genes, thereby exerting the regulatory control over the ripening process and the accumulation of soluble sugars and organic acids, ultimately influencing fruit ripening and quality formation. In conclusion, our findings illuminate the epi‐regulatory mechanism involving m6A in kiwifruit ripening, offering a fresh perspective for cultivating high‐quality kiwifruit with enhanced nutritional attributes.
GhSBI1, a CUP‐SHAPED COTYLEDON 2 homologue, modulates branch internode elongation in cotton
Authors: Zhong Weiping , Wu Lanxin , Li Yan , Li Xiaxuan , Wang Junyi , Pan Jingwen , Zhu Shouhong , Fang Shentao , Yao Jinbo , Zhang Yongshan , Chen Wei 
Published: July 2024

SummaryBranch length is an important plant architecture trait in cotton (Gossypium) breeding. Development of cultivars with short branch has been proposed as a main object to enhance cotton yield potential, because they are suitable for high planting density. Here, we report the molecular cloning and characterization of a semi‐dominant quantitative trait locus, Short Branch Internode 1(GhSBI1), which encodes a NAC transcription factor homologous to CUP‐SHAPED COTYLEDON 2 (CUC2) and is regulated by microRNA ghr‐miR164. We demonstrate that a point mutation found in sbi1 mutants perturbs ghr‐miR164‐directed regulation of GhSBI1, resulting in an increased expression level of GhSBI1. The sbi1 mutant was sensitive to exogenous gibberellic acid (GA) treatments. Overexpression of GhSBI1 inhibited branch internode elongation and led to the decreased levels of bioactive GAs. In addition, gene knockout analysis showed that GhSBI1 is required for the maintenance of the boundaries of multiple tissues in cotton. Transcriptome analysis revealed that overexpression of GhSBI1 affects the expression of plant hormone signalling‐, axillary meristems initiation‐, and abiotic stress response‐related genes. GhSBI1 interacted with GAIs, the DELLA repressors of GA signalling. GhSBI1 represses expression of GA signalling‐ and cell elongation‐related genes by directly targeting their promoters. Our work thus provides new insights into the molecular mechanisms for branch length and paves the way for the development of elite cultivars with suitable plant architecture in cotton.
Population‐level changes in perinatal death for pregnancies prior to and during the COVID‐19 pandemic: A pregnancy cohort analysis
Authors: Funk Anna , Stephenson Nikki , McNeil Deborah A. , Kuret Verena , Castillo Eliana , Parmar Radhmilla , Nerenberg Kara A. , Teare Gary , Klein Kristin , Metcalfe Amy 
Published: July 2024

AbstractBackgroundResults of population‐level studies examining the effect of the COVID‐19 pandemic on the risks of perinatal death have varied considerably.ObjectivesTo explore trends in the risk of perinatal death among pregnancies beginning prior to and during the pandemic using a pregnancy cohort approach.MethodsThis secondary analysis included data from singleton pregnancies ≥20 weeks' gestation in Alberta, Canada, beginning between 5 March 2017 and 4 March 2021. Perinatal death (i.e. stillbirth or neonatal death) was the primary outcome considered. The risk of this outcome was calculated for pregnancies with varying gestational overlap with the pandemic (i.e. none, 0–20 weeks, entire pregnancy). Interrupted time series analysis was used to further determine temporal trends in the outcome by time period of interest.ResultsThere were 190,853 pregnancies during the analysis period. Overall, the risk of perinatal death decreased with increasing levels of pandemic exposure; this outcome was experienced in 1.0% (95% confidence interval [CI] 0.9, 1.0), 0.9% (95% CI 0.8, 1.1) and 0.8% (95% CI 0.7, 0.9) of pregnancies with no overlap, partial overlap and complete pandemic overlap respectively. Pregnancies beginning during the pandemic that had high antepartum risk scores less frequently led to perinatal death compared to those beginning prior; 3.3% (95% CI 2.7, 3.9) versus 5.7% (95% CI 5.0, 6.5) respectively. Interrupted time‐series analysis revealed a decreasing temporal trend in perinatal death for pregnancies beginning ≤40 weeks prior to the start of the COVID‐19 pandemic (i.e. with pandemic exposure), with no trend for pregnancies beginning >40 weeks pre‐pandemic (i.e. no pandemic exposure).ConclusionWe observed a decrease in perinatal death for pregnancies overlapping with the COVID‐19 pandemic in Alberta, particularly among those at high risk of these outcomes. Specific pandemic control measures and government response programmes in our setting may have contributed to this finding.
Turing bifurcation in activator–inhibitor (depletion) models with cross‐diffusion and nonlocal terms
Authors: Fu Meijia , Liu Ping , Shi Qingyan 
Published: July 2024

AbstractIn this paper, we consider the instability of a constant equilibrium solution in a general activator–inhibitor (depletion) model with passive diffusion, cross‐diffusion, and nonlocal terms. It is shown that nonlocal terms produce linear stability or instability, and the system may generate spatial patterns under the effect of passive diffusion and cross‐diffusion. Moreover, we analyze the existence of bifurcating solutions to the general model using the bifurcation theory. At last, the theoretical results are applied to the spatial water–biomass system combined with cross‐diffusion and nonlocal grazing and Holling–Tanner predator–prey model with nonlocal prey competition.
Technique for guttural pouch bead removal using a novel three‐dimensional (3D)‐printed instrument
Authors: Cardona Guillermo C. , Dahlgren Linda A. , Byron Christopher R. , McKenzie Harold C. , Werre Stephen R. , Bogers Sophie H. 
Published: July 2024

AbstractObjectiveThe aim of the present study was to determine if a three‐dimensional (3D)‐printed instrument technique would improve lavage removal of plastic beads (guttural pouch [GP] chondroid mimics) through a dorsal pharyngeal recess (DPR) fenestration. We hypothesized that using a 3D‐printed instrument placed through the DPR fenestration would remove more beads, reduce lavage time and incur less soft tissue damage than using a lavage tube control or instrument placement through the salpingopharyngeal ostium (SPO).Study designExperimental cadaveric study.Sample populationA total of 30 cadaveric equine heads.MethodsDPR fenestration was performed using transendoscopic laser and 50 plastic 12 mm beads were placed into one GP of horse heads. Four removal procedures using a 3D‐printed instrument or lavage tube control placed through the DPR fenestration or the SPO were compared. Number of beads removed and number of 2‐min lavage cycles to recover ≥96% of beads or three consecutive no‐yield cycles were recorded. Endoscopic soft tissue damage was graded. Data were compared by generalized estimating equations (GEE) model and Fisher's exact test (p < .05).ResultsMore beads (median 48 beads; range 0–49) were removed faster (median 24 beads/cycle; range 12–50) using the 3D‐printed instrument compared to control (median 6 beads; range 0–29, 0.66 beads/cycle, range 0–49). There was no difference between total beads removed or removal speed between placement sites. There was no difference in soft tissue damage between procedures.ConclusionOur 3D‐printed instrument enabled efficient plastic bead removal.Clinical significanceDPR fenestration and use of our 3D‐printed instrument represents an alternative to current chondroid removal techniques, warranting investigation in clinical cases.
El uso de Daniel en la composición del modelo de revelación em el Apocalipsis de Juan
Authors: Gonzaga Waldecir , Dos Santos Ribeiro Leandro 
Published: July 2024

Este artículo analiza el uso del libro del profeta Daniel en la composición de un modelo de revelación trinitaria en el Apocalipsis. Para verificar el uso del Antiguo Testamento en el Nuevo Testamento se utilizan los criterios desarrollados por Beale y por Hays, en diálogo con las discusiones sobre el uso de Daniel en Apocalipsis por el propio Beale y por Moyise. A partir de eso, buscase entender cómo el Apocalipsis utilizó las alusiones a los textos danielicos como estructuras básicas para la concepción de su modelo apocalíptico trinitario.De manera singular, se ve que las alusiones extraídas de Daniel esbozan cómo las personas del Dios Uno y Trino se relacionan entre sí en el proceso de autorrevelación divina, particularmente en cómo el Padre revela misterios apocalípticos; otorga iluminación, por su Espíritu, la comprensión de cuentos misteriosos y los realiza por medio del Hijo del Hombre. Algunas partes de Daniel son notoriamente complejas, incluso enigmáticas, pero con todos los elementos necesarios para un modelo de revelación trinitaria, y son precisamente estos elementos de Daniel de los que se sirve el autor del Apocalipsis, desarrollándolos, para componer un modelo en que Dios Trino se comunica a su Iglesia.Para plantear la posibilidad de un uso de Daniel en la composición de un modelo revelacional trinitario en el libro del Apocalipsis, se trabajan algunos temas: el método exegético del uso del Antiguo Testamento en el Nuevo Testamento, con sus varias colaboraciones, pensando en todos los libros del Nuevo Testamento; luego se trabaja el tema del uso del Antiguo Testamento, de una manera específica, en el libro de Apocalipsis, porque esto puede variar de un libro a otro; dado este paso, se examinan dos ejemplos concretos, a partir de la alusión de Dn 2,28-29.45 en Ap 1,1, tratando de comprender los contactos entre Dn 2,28-29 y Ap 1,1a; Dn 2.45 y Ap 1.1b. Con esto, se busca analizar cómo el autor del Apocalipsis habría entendido que podría usar Dn 2 para hablar del Dios Uno y Trino, revelador de misterios.