bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in posttransplantation care for kidney transplant recipients: A qualitative study highlighting gaps in psychological, social and exercise support
Authors: De Beir Jasmine , De Baets Stijn , Vandecruys Marieke , Renier Marie , De Smet Stefan , Van Craenenbroeck Amaryllis H. , Van Biesen Wim , Nagler Evi V. , Verbeke Francis , Calders Patrick , Vanden Wyngaert Karsten 
Published: July 2024

AbstractBackgroundKidney transplantation offers meaningful health improvements compared to dialysis, yet the quality of life and life expectancy of kidney transplant recipients still lag behind those of their healthy peers. Physical inactivity and poor physical fitness are prevalent among kidney transplant recipients, affecting overall life participation.ObjectivesTo explore challenges hindering life participation for kidney transplant recipients and reveal facilitators and barriers to integrating rehabilitation into their daily lives.DesignAn explorative study using a qualitative method.ParticipantsFourteen purposively selected kidney transplant recipients.ApproachSemistructured, individual interviews were conducted posttransplantation. The following topics were covered: living with chronic kidney disease, pretransplantation challenges, posttransplantation recovery, engagement in various activities, including physical activity, and the need for supervised exercise rehabilitation programmes. Interviews were recorded and transcribed verbatim, and an inductive thematic analysis approach was used.FindingsData saturation occurred after analysing 12 interviews, revealing two main themes: the impact on life participation and the impact on physical and mental functioning. Participants expressed the need for comprehensive posttransplant care, including mental health support, family education and guidance on returning to work. Structured support in managing physical fitness, tailored to individual preferences, was also recognised as important.ConclusionsThe study underscores the necessity for a biopsychosocial approach to posttransplant care that addresses the multifaceted challenges faced by kidney transplant recipients. A multidisciplinary approach, tailored support, education and individualised exercise programmes are crucial for enhancing their overall well‐being and integrating rehabilitation into their daily lives, considering both physical and psychosocial aspects.
Sexuality education for school‐aged children and adolescents: A concept analysis
Authors: Carmichael Nelly , Amiri Azita 
Published: July 2024

AbstractPurposeSexuality education is essential for children and adolescents to make better choices regarding their sexual well‐being. Parents, teachers, and healthcare providers are not always comfortable talking to school‐age children about sex, making sexuality education a concept of interest to be explored. The purpose of this paper is to explain the concept of sexuality education in school‐aged children and adolescents.Design and MethodsThis paper uses Walker and Avant's concept analysis to help clarify its meaning. The sexuality education concept is explored in this article in the views of educating school systems K‐12 with three types of sexuality education (abstinence‐only, abstinence‐plus, and comprehensive sexuality education). Literature from 1990 to 2023 was retrieved using PubMed, Google Scholar, and CINAHL.ResultsA model case is used to demonstrate the importance of sexuality education. A borderline case and a related case are proposed to explain other uses of the concept. Defining attributes, antecedents, consequences, and empirical referents are explored. Antecedents of sexuality education are grouped into three categories: resources, political environment, and social beliefs.Practice ImplicationsA conceptual understanding of sexuality education can foster nurses' confidence in talking to their patients about this topic and encourage nurses to advocate for comprehensive sexuality education nationwide.
Evolving intellectual property protection for new corn varieties in the United States: An empirical analysis
Authors: Chan H. Phoebe 
Published: July 2024

AbstractThe US aﬀirmed patent protection for genetically modified plant traits in 1985, asserting that firms could patent new hybrid plant varieties when formerly plant variety protection was the primary means to protect hybrid varieties. This paper examines how firms' intellectual property choices have changed for new corn varieties created during the years 1985–2012. The data suggests that firms increasingly rely on patent protection as their only form of intellectual property protection for new varieties. For varieties with patent protection, low‐valued varieties, as determined by low patent renewal rates, receive less net benefit from obtaining plant variety protection compared to high‐valued varieties.
On the convergence of a linearly implicit finite element method for the nonlinear Schrödinger equation
Authors: Asadzadeh Mohammad , Zouraris Georgios E. 
Published: July 2024

AbstractWe consider a model initial‐ and Dirichlet boundary–value problem for a nonlinear Schrödinger equation in two and three space dimensions. The solution to the problem is approximated by a conservative numerical method consisting of a standard conforming finite element space discretization and a second‐order, linearly implicit time stepping, yielding approximations at the nodes and at the midpoints of a nonuniform partition of the time interval. We investigate the convergence of the method by deriving optimal‐order error estimates in the and the norm, under certain assumptions on the partition of the time interval and avoiding the enforcement of a Courant‐Friedrichs‐Lewy (CFL) condition between the space mesh size and the time step sizes.
Influence of Thermal Gradients and Arctic Temperatures on the Mechanical Properties and Fracture Behavior of Woven Carbon and Woven Kevlar® Composites
Authors: Buendia Lucero , Torres Itzel , Ornelas Alejandro , Castellanos Alejandra 
Published: July 2024

Abstract
This study investigates the impact of thermal gradients (−60/23 °C), arctic temperature (−60 °C), and room temperature (23 °C) on the tensile and flexural properties of woven carbon and Kevlar® fiber-reinforced polymer (FRP) composite materials. A novel custom-built environmental chamber was employed to simulate thermal gradients by exposing opposite sides of the samples to −60 °C and 23 °C simultaneously. The woven carbon and Kevlar® FRP composite materials were manufactured using the vacuum-assisted resin transfer molding (VARTM) process. Then, the samples were conditioned at three distinct temperatures: −60 °C, 23 °C, and a thermal gradient of −60/23 °C. After conditioning, they were subjected to tensile and flexural testing to evaluate their mechanical properties. Finally, a detailed fractographic analysis was performed. The results showed that both carbon and Kevlar® FRP composites experienced an increase in their tensile and flexural properties (stiffness and strength) at lower temperatures (−60/23 °C and −60 °C), accompanied by a decrease in strain at failure when compared to samples tested at 23 °C. The main failure mechanism observed was fiber fracture for all the carbon FRP composite samples across all temperatures. In contrast, Kevlar® samples exhibited a combination of fiber fracture, matrix cracking, and delamination. The samples exposed to thermal gradients experienced brittle failure behavior, like the ones seen in the samples exposed to −60 °C. Their tensile and flexural properties showed intermediate values, falling between the samples conditioned to −60 °C and 23 °C.
Patient Characteristics Associated with Intended Nonguideline Chemotherapy in Women with Stage I to IIIA Breast Cancer
Authors: Bhimani Jenna , O’Connell Kelli , Persaud Sonia , Blinder Victoria , Burganowski-Doud Rachael P. , Ergas Isaac J. , Gallagher Grace B. , Griggs Jennifer J. , Heon Narre , Kolevska Tatjana , Kotsurovskyy Yuriy , Kroenke Candyce H. , Laurent Cecile. A. , Liu Raymond , Nakata Kanichi G. , Rivera Donna R. , Roh Janise M. , Tabatabai Sara , Valice Emily , Bandera Elisa V. , Aiello Bowles Erin J. , Kushi Lawrence H. , Kantor Elizabeth D. 
Published: July 2024

Abstract

Background:
Guidelines informing chemotherapy regimen selection are based on clinical trials with participants who do not necessarily represent general populations with breast cancer. Understanding who receives nonguideline regimens is important for understanding real-world chemotherapy administration and how it relates to patient outcomes.

Methods:
Using data from the Optimal Breast Cancer Chemotherapy Dosing (OBCD) study, based at Kaiser Permanente Northern California (2006–2019) and Kaiser Permanente Washington (2004–2015), we use logistic regression to examine the associations between patient characteristics and receipt of nonguideline chemotherapy regimens among 11,293 women with primary stage I to IIIA breast cancer receiving chemotherapy.

Results:
The use of nonguideline regimens was strongly associated with several factors, including older age [≥80 vs. 18–39 years: OR, 5.25; 95% confidence interval (CI), 3.06–9.00; P-trend = 0.002] and HER2 status (HER2+ vs. HER2−: OR, 3.44; 95% CI, 3.06–3.87) and was less likely in women with larger tumor size (&gt;5 cm vs. 0.1 to ≤0.5 cm: OR, 0.56; 95% CI, 0.36–0.87; P-trend = 0.01) and diagnosed in later years (2012–2019 vs. 2005–2011: OR, 0.80; 95% CI, 0.71–0.90). Factors associated varied by type of nonguideline regimens. For example, women with comorbidity and older age were more likely to receive nonguideline drug combinations in particular, whereas women with larger tumor size were less likely to receive nonguideline administration schedules.

Conclusions:
Nonguideline chemotherapy regimens are more likely in certain patient populations.

Impact:
These associations highlight that vulnerable patient populations may be less likely to receive guideline care, and thus, real-world studies are essential for understanding how the use of nonguideline regimens impacts patient outcomes in these groups.
Dynamic Modeling and Experimental Verification of an RPR Type Compliant Parallel Mechanism with Low Orders
Authors: Zhang Shuang , Liu Jingfang , Ding Huafeng , Zhang Yanbin 
Published: July 2024

AbstractEfficiency of calculating a dynamic response is an important point of the compliant mechanism for posture adjustment. Dynamic modeling with low orders of a 2R1T compliant parallel mechanism is studied in the paper. The mechanism with two out-of-plane rotational and one lifting degrees of freedom (DoFs) plays an important role in posture adjustment. Based on elastic beam theory, the stiffness matrix and mass matrix of the beam element are established where the moment of inertia is considered. To improve solving efficiency, a dynamic model with low orders of the mechanism is established based on a modified modal synthesis method. Firstly, each branch of the RPR type mechanism is divided into a substructure. Subsequently, a set of hypothetical modes of each substructure is obtained based on the C-B method. Finally, dynamic equation of the whole mechanism is established by the substructure assembly. A dynamic experiment is conducted to verify the dynamic characteristics of the compliant mechanism.
An ecotype-specific effect of osmopriming and melatonin during salt stress in Arabidopsis thaliana
Authors: Juraniec Michał , Goormaghtigh Erik , Posmyk Małgorzata M. , Verbruggen Nathalie 
Published: July 2024

Abstract
Background
Natural populations of Arabidopsis thaliana exhibit phenotypic variations in specific environments and growth conditions. However, this variation has not been explored after seed osmopriming treatments. The natural variation in biomass production and root system architecture (RSA) was investigated across the Arabidopsis thaliana core collection in response to the pre-sawing seed treatments by osmopriming, with and without melatonin (Mel). The goal was to identify and characterize physiologically contrasting ecotypes.

Results
Variability in RSA parameters in response to PEG-6000 seed osmopriming with and without Mel was observed across Arabidopsis thaliana ecotypes with especially positive impact of Mel addition under both control and 100 mM NaCl stress conditions. Two ecotypes, Can-0 and Kn-0, exhibited contrasted root phenotypes: seed osmopriming with and without Mel reduced the root growth of Can-0 plants while enhancing it in Kn-0 ones under both control and salt stress conditions. To understand the stress responses in these two ecotypes, main stress markers as well as physiological analyses were assessed in shoots and roots. Although the effect of Mel addition was evident in both ecotypes, its protective effect was more pronounced in Kn-0. Antioxidant enzymes were induced by osmopriming with Mel in both ecotypes, but Kn-0 was characterized by a higher responsiveness, especially in the activities of peroxidases in roots. Kn-0 plants experienced lower oxidative stress, and salt-induced ROS accumulation was reduced by osmopriming with Mel. In contrast, Can-0 exhibited lower enzyme activities but the accumulation of proline in its organs was particularly high. In both ecotypes, a greater response of antioxidant enzymes and proline accumulation was observed compared to mechanisms involving the reduction of Na+ content and prevention of K+ efflux.

Conclusions
In contrast to Can-0, Kn-0 plants grown from seeds osmoprimed with and without Mel displayed a lower root sensitivity to NaCl-induced oxidative stress. The opposite root growth patterns, enhanced by osmopriming treatments might result from different protective mechanisms employed by these two ecotypes which in turn result from adaptive strategies proper to specific habitats from which Can-0 and Kn-0 originate. The isolation of contrasting phenotypes paves the way for the identification of genetic factors affecting osmopriming efficiency.
Motivation in caregiving among mothers of children with intellectual and developmental disabilities in Iran: A qualitative study
Authors: Hosseini Seyed Javad , Ramezani Monir , Ashrafzadeh Farah , Jamali Jamshid 
Published: July 2024

Abstract
Background
The motivation of caregivers plays a crucial role in the treatment, follow-up, and care of children with intellectual and developmental disabilities. Previous studies have focused on the older people and end-stage diseases, while giving less attention to the motivation of mothers caring for children with special needs. This study aimed to explore the motivations of mothers caring for children with intellectual and developmental disabilities in Iran.

Methods
This study employed a qualitative approach, guided by the Self-Determination Theory. Purposeful sampling was initially used, followed by theoretical sampling until data saturation was achieved. Data were collected through semi-structured interviews with 26 mothers of children with intellectual and developmental disabilities. Mayring’s seven-step directed content analysis approach was utilized for coding and categorization. The research adhered to ethical standards and ensured data trustworthiness through credibility, dependability, confirmability, and transferability measures.

Results
The findings revealed that mothers’ caregiving motivations could be classified into four main categories: (I) intrinsic, (II) identified-extrinsic, (III) introjected-extrinsic, and (IV) external-extrinsic. Additionally, twelve sub-categories were identified within these four main categories.

Conclusion
The findings revealed that mothers demonstrated varying levels of intrinsic and extrinsic motivations in caring for children with intellectual and developmental disabilities. By recognizing and enhancing the diverse sources of motivation, healthcare providers and policymakers can better support mothers in their caregiving roles, ultimately contributing to improved outcomes for both the mothers and their children.
Assessing personal protective equipment usage and its correlation with knowledge, attitudes, performance, and safety culture among workers in small and medium-sized enterprises
Authors: Khoshakhlagh Amir Hossein , Malakoutikhah Mahdi , Park JeeWoong , Kodnoueieh Mohammad Dehghani , Boroujeni Zakiyeh Rafieian , Bahrami Maryam , Ramezani Fatemeh 
Published: July 2024

Abstract
Background
The use of personal protective equipment (PPE) should be a culture of a workplace, and deeply rooted in worker behavior and attitude during their practice. According to the recent studies only 64% of the workers use PPE properly. The present study aims to investigate the utilization of PPE among workers in small and medium-sized enterprises (SMEs), and its relationship with knowledge, attitude, performance, and safety culture among workers.

Methods
This cross-sectional study was carried out using a questionnaire tool across SMEs in Kashan city in year 2023. The used tool included three questionnaires: demographic, safety culture, and knowledge, attitude and performance. Study papulation was 529 SMEs. Totally, the sample size was 369 persons and questionnaires were distributed among the workers of SMEs. Finally, SPSS software was used for statistical analysis and structural equation modeling. Various statistical tests including T-Test, ANOVA, RMSEA, CFI, TLI, and the chi-square ratio were employed.

Results
The mean values (standard deviation) of age and work experience were 35.19 (12.33), and 15.60 (1.69) years, respectively. Among the 369 participants, 267 participants (72.4%) indicated that they use some PPE, although not all types. However, 102 individuals (27.7%) do not employ any PPE. The lowest score for safety culture dimension was attributed to safety training at 1.58. The results of the final model indicate that the assumed relationships between variables, as outlined in the study objectives, were well established, with all connections proving statistically significant.

Conclusion
It can be concluded that the missing of inadequate legal supervision for small industries exists. Therefore, it can be inferred that if supervision and regulation are enhanced for safety training and implementation that may lead to increased usage of PPE.
Evaluation of the effect of dental anxiety on vital signs in the order of third molar extraction
Authors: Özmen Elif Esra , Taşdemir İsmail 
Published: July 2024

Abstract
Background
Dental anxiety is a prevalent concern affecting patients undergoing various dental procedures, particularly surgical interventions. Understanding the impact of patients’ anxiety levels on their physiological responses during dental surgeries, such as third molar impaction surgery, is crucial for optimizing patient care and outcomes. Therefore, this study aimed to investigate the effect of patients’ anxiety levels on vital signs during third molar teeth impaction surgery.

Methods
A cross-sectional study was conducted, including 45 randomly selected, healthy patients. Demographic information was recorded after obtaining consent from the patients prior to surgical intervention. Preoperative anxiety levels were determined using the Modified Dental Anxiety Scale (MDAS). Pupil measurements were taken from the patients before surgery, at 10 min after the surgery began, and at 10 min after the surgery ended. Systolic (SBP) and diastolic (DBP) blood pressure, pulse rate, temperature, and haemoglobin oxygen saturation (SpO2) values were recorded.

Results
The MDAS test results were statistically significantly higher in women compared to men (p < 0.001). Positive correlations were observed between MDAS score and both preoperative pulse rate (r = 0.344, p = 0.021) and SpO2 level during the operation (r = 0.462, p = 0.001). However, no significant correlations were found between MDAS and DBP (p = 0.575), SBP (p = 0.176), fever (p = 0.238), or pupil diameter (p = 0.338).

Conclusions
Third molar impaction surgery induces anxiety in adult patients 20 years and older. Vital sign monitoring provides information about the patient’s emotional state, both before and during the procedure. Since anxiety causes changes in vital signs during dental procedures, it is important to follow these findings to have an idea about the general condition of the patients.
Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Authors: Angelopoulou Andriani , Theocharous Giorgos , Valakos Dimitrios , Polyzou Aikaterini , Magkouta Sophia , Myrianthopoulos Vassilios , Havaki Sophia , Fiorillo Marco , Tremi Ioanna , Vachlas Konstantinos , Nisotakis Theodoros , Thanos Dimitris-Foivos , Pantazaki Anastasia , Kletsas Dimitris , Bartek Jiri , Petty Russell , Thanos Dimitris , McCrimmon Rory J , Papaspyropoulos Angelos , Gorgoulis Vassilis G 
Published: July 2024

AbstractNon-small cell lung cancer (NSCLC) constitutes one of the deadliest and most common malignancies. The LKB1/STK11 tumour suppressor is mutated in ∼ 30% of NSCLCs, typically lung adenocarcinomas (LUAD). We implemented zebrafish and human lung organoids as synergistic platforms to pre-clinically screen for metabolic compounds selectively targeting LKB1-deficient tumours. Interestingly, two kinase inhibitors, Piceatannol and Tyrphostin 23, appeared to exert synthetic lethality with LKB1 mutations. Although LKB1 loss alone accelerates energy expenditure, unexpectedly we find that it additionally alters regulation of the key energy homeostasis maintenance player leptin (LEP), further increasing the energetic burden and exposing a vulnerable point; acquired sensitivity to the identified compounds. We show that compound treatment stabilises Hypoxia-inducible factor 1-alpha (HIF1A) by antagonising Von Hippel-Lindau (VHL)-mediated HIF1A ubiquitination, driving LEP hyperactivation. Importantly, we demonstrate that sensitivity to piceatannol/tyrphostin 23 epistatically relies on a HIF1A-LEP-Uncoupling Protein 2 (UCP2) signaling axis lowering cellular energy beyond survival, in already challenged LKB1-deficient cells. Thus, we uncover a pivotal metabolic vulnerability of LKB1-deficient tumours, which may be therapeutically exploited using our identified compounds as mitochondrial uncouplers.
Revealing the clinical impact of MTOR and ARID2 gene mutations on MALT lymphoma of the alimentary canal using targeted sequencing
Authors: Huang Xiang , Zeng Jiafei , Luo Yuqing , Luo Shuai , Li Yao , Wang Jinjing 
Published: July 2024

AbstractExtranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) are a group of diseases with marked heterogeneity, including clinical, immunohistochemical, and molecular heterogeneity. The disease remains unspecified in the genetic landscape with only a few sequencing studies to date; however, systematic studies of alimentary canal MALT lymphoma have not been reported. To better understand the genetics of this tumor, targeted sequencing in a group of 31 cases (including 2 esophageal, 2 colonic, 4 small intestinal, and 23 gastric cases) and two cases of lymph node hyperplasiawere performed. We found epigenetic regulation (DNMT3A, KMT2D, KMT2A, EP300, TET2, etc.), signaling pathways (APC, CHD8, TNFAIP3, TNFRSF14, ZAP70, NF1,), and tumor suppressor genes (TP53, BCORL1, FOXO1, ATM, etc.) involved. Moreover, we found MTOR gene mutations in 16% of the cases that made these patients more prone to recurrence and metastasis than those with MTOR wild type genes. More interestingly, ARID2 mutations were detected in 32% of all the cases, and the mutation rate was higher and statistically significant in Helicobacter pylori (Hp)-negative patients in the gastric group. Therefore, this study found that MTOR and ARID2 gene mutations have pathogenic and prognostic implications.