bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lenalidomide and vorinostat maintenance after autologous transplant in multiple myeloma
Authors: Sborov Douglas W. , Benson Don M. , Williams Nita , Huang Ying , Bowers Mindy A. , Humphries Kristina , Efebera Yvonne , Devine Steven , Hofmeister Craig C. 
Published: June 2015

SummarySingle‐agent post‐autologous transplant maintenance therapy with lenalidomide is standard of care for patients with multiple myeloma. The tolerability and effectiveness of combination post‐transplant maintenance therapy is unknown, so we investigated lenalidomide and vorinostat (suberoylanilide hydroxamic acid) in this setting, hypothesizing that the regimen would be well tolerated and associated with an improved post‐transplant response. This trial followed a standard 3 × 3 dose escalation phase 1 design. Vorinostat was administered beginning day +90 post‐haematopoietic stem cell transplantation for days 1–7 and 15–21, and lenalidomide was started at 10 mg days 1–21, both on a 28‐d cycle. The primary endpoint was maximum tolerated dose and dose limiting toxicities were assessed during the first cycle. Treatment was well tolerated in 16 enrolled patients. During Cycle 1, the most common toxicities included cytopenias, gastrointestinal complaints and fatigue. Seven patients improved their transplant response after starting combination therapy. The median follow‐up was 38·4 months, and the median progression‐free survival and overall survival have yet to be reached. This oral post‐transplant maintenance regimen was well tolerated. This is the first trial to publish results on the use of a histone deacetylase inhibitor in the maintenance setting, and it provides rationale for the ongoing randomized trial in maintenance (ISRCTN 49407852).Trial Registration: NCT00729118
A pilot memory café for people with Learning Disabilities and memory difficulties
Authors: Kiddle Hannah , Drew Neil , Crabbe Paul , Wigmore Jonathan 
Published: June 2015

Accessible summary

Memory cafés help people without learning disabilities who have dementia. We wanted to know whether memory cafés can help people with learning disabilities and memory problems.

We ran a memory café for 12 weeks for people with learning disabilities. We watched how people got on in the café and how happy they looked. We asked people what they thought of the memory café. We also asked their carers.

The people who came to the memory café said it helped. They seemed happier each week. Carers said that after the memory café people talked more, were more alert and did more activities at home.

SummaryMemory cafés have been found to normalise experiences of dementia and provide access to an accepting social network. People with learning disabilities are at increased risk of developing dementia, but the possible benefits of attending a memory café are not known. This study evaluates a 12‐week pilot memory café for people with learning disabilities in terms of adaptations required and benefits of attending. Results indicate that affect levels significantly improved across the course of the café and that communication, interaction, alertness and participation in other activities improved outside the café. Future plans for attendance at memory cafés for people with learning disabilities are discussed.
Paternalism and factitious disorder: medical treatment in illness deception
Authors: Fry Anthony , Gergel Tania L. 
Published: June 2015

AbstractThe primary aims are to consider whether a range of paternalistic medical interventions can be justified in the treatment of factitious disorder (FD) and to show that the particularities of FD and its management make it an ideal phenomenon to highlight the difficulties of balancing respect for self‐determination, responsibility and duty of care in psychiatry. FD is usually classified as a mental disorder involving deliberate and hidden feigning or inducement of illness, in order to achieve patient status. Both the nature of the disorder and the approach to treatment are controversial and under‐researched. It is argued that FD should be classified as a mental disorder; may well expose the patient to extreme risk; can warrant paternalistic interventions, in order to fulfil duty of care. Moreover, treatment of FD is inherently paternalistic and therefore raises interesting questions about justifications and type of paternalistic interventions in psychiatry both for FD and in general. A brief account of key questions concerning psychiatry and paternalism is followed by some case histories of FD, the clinical dilemmas posed and the question of how this disorder might warrant paternalistic interventions. In order to answer this question, two things are considered: the legitimacy and character of FD as a mental disorder; possible frameworks for and types of paternalistic interventions. To conclude, it is argued that there are no compelling reasons for rejecting the use of paternalistic interventions for FD, but that further investigation of FD and type and frameworks for psychiatric paternalism, in relation to FD and other mental disorders, are urgently needed.
Marine Snails and Slugs: a Great Place To Look for Antiviral Drugs
Authors: Dang Vinh T. , Benkendorff Kirsten , Green Tim , Speck Peter 
Published: June 2015

ABSTRACT
Molluscs, comprising one of the most successful phyla, lack clear evidence of adaptive immunity and yet thrive in the oceans, which are rich in viruses. There are thought to be nearly 120,000 species of Mollusca, most living in marine habitats. Despite the extraordinary abundance of viruses in oceans, molluscs often have very long life spans (10 to 100 years). Thus, their innate immunity must be highly effective at countering viral infections. Antiviral compounds are a crucial component of molluscan defenses against viruses and have diverse mechanisms of action against a wide variety of viruses, including many that are human pathogens. Antiviral compounds found in abalone, oyster, mussels, and other cultured molluscs are available in large supply, providing good opportunities for future research and development. However, most members of the phylum Mollusca have not been examined for the presence of antiviral compounds. The enormous diversity and adaptations of molluscs imply a potential source of novel antiviral compounds for future drug discovery.
Lung CD8+T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+T Cells
Authors: Wen Sherry C. , Schuster Jennifer E. , Gilchuk Pavlo , Boyd Kelli L. , Joyce Sebastian , Williams John V. 
Published: June 2015

ABSTRACTHuman metapneumovirus (HMPV) is a major cause of respiratory disease in infants, the elderly, and immunocompromised individuals worldwide. There is currently no licensed HMPV vaccine. Virus-like particles (VLPs) are an attractive vaccine candidate because they are noninfectious and elicit a neutralizing antibody response. However, studies show that serum neutralizing antibodies are insufficient for complete protection against reinfection and that adaptive T cell immunity is important for viral clearance. HMPV and other respiratory viruses induce lung CD8+T cell (TCD8) impairment, mediated by programmed death 1 (PD-1). In this study, we generated HMPV VLPs by expressing the fusion and matrix proteins in mammalian cells and tested whether VLP immunization induces functional HMPV-specific TCD8responses in mice. C57BL/6 mice vaccinated twice with VLPs and subsequently challenged with HMPV were protected from lung viral replication for at least 20 weeks postimmunization. A single VLP dose elicited F- and M-specific lung TCD8s with higher function and lower expression of PD-1 and other inhibitory receptors than TCD8s from HMPV-infected mice. However, after HMPV challenge, lung TCD8s from VLP-vaccinated mice exhibited inhibitory receptor expression and functional impairment similar to those of mice experiencing secondary infection. HMPV challenge of VLP-immunized μMT mice also elicited a large percentage of impaired lung TCD8s, similar to mice experiencing secondary infection. Together, these results indicate that VLPs are a promising vaccine candidate but do not prevent lung TCD8impairment upon HMPV challenge.IMPORTANCEHuman metapneumovirus (HMPV) is a leading cause of acute respiratory disease for which there is no licensed vaccine. Virus-like particles (VLPs) are an attractive vaccine candidate and induce antibodies, but T cell responses are less defined. Moreover, HMPV and other respiratory viruses induce lung CD8+T cell (TCD8) impairment mediated by programmed death 1 (PD-1). In this study, HMPV VLPs containing viral fusion and matrix proteins elicited epitope-specific TCD8s that were functional with low PD-1 expression. Two VLP doses conferred sterilizing immunity in C57BL/6 mice and facilitated HMPV clearance in antibody-deficient μMT mice without enhancing lung pathology. However, regardless of whether responding lung TCD8s had previously encountered HMPV antigens in the context of VLPs or virus, similar proportions were impaired and expressed comparable levels of PD-1 upon viral challenge. These results suggest that VLPs are a promising vaccine candidate but do not prevent lung TCD8impairment upon HMPV challenge.
Change in quality of life in patients with acromegaly after treatment with octreotide LAR: first application of AcroQoL in Korea
Authors: Chin Sang Ouk , Chung Choon Hee , Chung Yoon-Sok , Kim Byung-Joon , Kim Hee Young , Kim In-Ju , Kim Jung Guk , Kim Min-Seon , Kim Seong-Yeon , Lee Eun Jig , Lee Ki Young , Kim Sung-Woon 
Published: June 2015

ObjectivesThis study was designed to investigate changes in health-related quality of life (HRQoL) of patients with acromegaly in Korea after medical treatment with octreotide LAR using the validated Korean version of the acromegaly quality of life questionnaire (AcroQoL).DesignA prospective, open-label, single-arm study.Setting11 tertiary centres in Korea.Participants58 Korean patients (aged 21–72 years) who were newly diagnosed with acromegaly between 2009 and 2012 were prescribed octreotide LAR 20 mg at the time of enrolment. During 24 weeks of observation, AcroQoL survey questionnaires and measurement of growth hormone insulin-like growth factor 1(GH/IGF-I) were performed at baseline, week 12 and week 24.Main outcome measuresWe assessed the HRQoL of Korean patients with acromegaly after medical treatment with octreotide LAR using the validated Korean version of the AcroQoL questionnaire.ResultsPatients had a mean age of 47.2 years (29 males), and GH and IGF-I significantly decreased during the first 12 weeks (GH: 4.8 vs 1.9 μg/L, p<0.001; IGF-I: 497 vs 265 μg/L, p<0.001), but showed insignificant change at week 24 (GH: 2.3 μg/L; IGF-I: 294 μg/L). Only AcroQoL scores for the psychological appearance subdomain showed a significant increase during the entire 24 weeks (p<0.05). The change in the psychological appearance subdomain of AcroQoL scores demonstrated a significant but weak negative correlation with change in IGF-I levels (r=−0.282, p=0.039). When patients were divided into two groups according to their disease activity at week 24 (controlled vs uncontrolled), there was no difference in AcroQoL scores, but the psychological appearance subdomain of the two groups appeared to change differently over the entire 24-week period (p=0.047).Conclusions:Medical treatment with octreotide LAR in patients with acromegaly has a limited contribution to HRQoL as assessed by the AcroQoL.
Adsorption of pathogenic microorganisms, NH4+ and heavy metals from wastewater by clinoptilolite using bed laminar flow
Authors: Ferronato Chiara , Vianello Gilmo , Antisari Livia Vittori 
Published: June 2015

AbstractThe contamination of water bodies in urban areas is a serious problem, which may increase when wastewater is discharged without complete remediation. Due to their high adsorption capacity and ion-exchange properties, zeolites, such as clinoptilolite, can be used successfully to detoxify the wastewater before discharging it into the water body. In this study, experimental use of clinoptilolite is presented for water remediation. A static flow (A) and a laminar flow (B) method were applied in order to evaluate the efficiency of clinoptilolite for reducing different contaminants in the outflow wastewater of an old municipal treatment plant in Bologna District (Northern Italy). Mesocosm experiments were performed in order to achieve reduction of the microbial faecal indicators and of the excess nutrients and heavy metals in the effluent. During the experiments, pathogenic microorganisms, ammonium and heavy metals were reduced by as much as between 78 and 95% within 24 h, highlighting the great efficiency of this low-cost material for water remediation.
Are public sector workers different? Cross-European evidence from elderly workers and retirees
Authors: Tonin Mirco , Vlassopoulos Michael 
Published: June 2015

Abstract
We investigate whether public and private sector employees differ in terms of public service motivation using a representative sample of elderly workers from 12 European countries. We find that public sector workers, both those currently employed and those already retired, are significantly more prosocial; however, the difference in prosociality is explained by differences in the composition of the workforce across the two sectors, in terms of (former) workers’ education and occupation. Subsample analysis reveals that public sector former workers in education are more prosocial even after controlling for a rich set of characteristics.

JEL codes: D64; H83; J45
Ductal Stent Implantation in Tetralogy of Fallot with Aortic Arch Abnormality
Authors: Tola Hasan Tahsin , Ergul Yakup , Saygi Murat , Ozyilmaz Isa , Guzeltas Alper , Odemis Ender 
Published: June 2015

Stenting of patent ductus arteriosus is an alternative to palliative cardiac surgery in newborns with duct-dependent or decreased pulmonary circulation; however, the use of this technique in patients with an aortic arch abnormality presents a challenge. Tetralogy of Fallot is a congenital heart defect that is frequently associated with anomalies of the aortic arch and its branches. The association is even more common in patients with chromosome 22q11 deletion.
We present the case of an 18-day-old male infant who had cyanosis and a heart murmur. After an initial echocardiographic evaluation, the patient was diagnosed with tetralogy of Fallot and right-sided aortic arch. The pulmonary annulus and the main pulmonary artery and its branches were slightly hypoplastic; the ductus arteriosus was small. Conventional and computed tomographic angiograms revealed a double aortic arch and an aberrant left subclavian artery. The right aortic arch branched into the subclavian arteries and continued into the descending aorta, whereas the left aortic arch branched into the common carotid arteries and ended with the patent ductus arteriosus. After evaluation of the ductal anatomy, we implanted a 3.5 × 15-mm coronary stent in the duct. Follow-up injections showed augmented pulmonary flow and an increase in oxygen saturation from 65% to 94%. The patient was also found to have chromosome 22q11 deletion.
Unicuspid Unicommissural Aortic Valve: An Extremely Rare Congenital Anomaly
Authors: Singh Sukhjeet , Ghayal Puneet , Mathur Atish , Mysliwiec Margaret , Lovoulos Constantinos , Solanki Pallavi , Klapholz Marc , Maher James 
Published: June 2015

Abstract
Unicuspid aortic valve is a rare congenital malformation that usually presents in the 3rd to 5th decade of life—and usually with severe aortic stenosis or regurgitation. It often requires surgical correction. Diagnosis can be made with 2- or 3-dimensional transthoracic or transesophageal echocardiography, cardiac computed tomography, or cardiac magnetic resonance imaging.
We report the case of a 31-year-old man who presented with dyspnea on exertion due to severe aortic stenosis secondary to a unicuspid unicommissural aortic valve. After aortic valve replacement, this patient experienced complete heart block that required the placement of a permanent pacemaker.
Late Postoperative Prosthetic Pulmonary Valve Endocarditis in a 13-Year-Old Girl with Repaired Tetralogy of Fallot
Authors: O'Brien Michael C. , Pourmoghadam Kamal K. , DeCampli William M. 
Published: June 2015

Prosthetic pulmonary valve endocarditis has infrequently been described outside large cohort reviews, which have typically focused on infections of the left-sided heart valves. Hence, the pathogenesis, clinical presentation, and management principles of prosthetic pulmonary valve endocarditis have not been well differentiated from those of infected aortic and mitral valves. More patients with repaired tetralogy of Fallot are reaching adulthood and will need pulmonary valve implantation. Consequently, a focus on this infrequent but serious cardiac infection is needed, to learn what characteristics might distinguish it from infections of left-sided heart valves.
We report the case of a 13-year-old girl with repaired tetralogy of Fallot who presented with fever and nonspecific symptoms. The patient initially failed to meet the Duke criteria for endocarditis but was then found to have endocarditis of her prosthetic pulmonary valve. We explanted the valve and replaced it with a pulmonary homograft, after which the patient had no infectious sequelae. In addition to presenting the patient's case, we review the literature on surgically inserted prosthetic pulmonary valves and discuss the primary management concerns when those valves become infected with endocarditis.
Lizenzverwaltung von elektronischen Zeitschriften mit KnowledgeBase Plus (KB+)
Authors: Ahlborn Benjamin 
Published: June 2015

Zusammenfassung:
Wissenschaftliche Bibliotheken geben heute einen substantiellen Teil ihres Etats für elektronische Medien aus. Die heute eingesetzten lokalen Erwerbungssysteme bieten meist nur eine lückenhafte Unterstützung für Electronic Resource Management (ERM). Seit 2013 wird von britischen Konsortien und Bibliotheken die Software Knowledgebase Plus (KB+) für die Verwaltung von elektronischen Zeitschriftenpaketen und Lizenzen eingesetzt. KB+ ersetzt kein vollwertiges ERM-System, da Informationen zu Finanzen noch nicht abgebildet werden, es bietet aber eine Reihe von Funktionen, die auch für deutsche Bibliotheken interessant sein könnten.
Forging new pathways for research on language learning motivation
Authors: Raby Françoise 
Published: June 2015

Abstract
Research on motivation in the field of applied linguistics seeks to better understand how and why learners become involved in learning activities and maintain their efforts in this regard. Dörnyei provided a seminal model drawing essentially from cognitive and social psychology (Dörnyei, 2001). In the wake of his reflection, and after investigating motivation in a range of academic contexts, we are now able to present our own model, which is dynamic, weighted, and polytomic (Raby, 2007). After presenting cognitive ergonomics as a new pathway for research in second language acquisition, we shall present the results of our investigations in foreign language learning motivation in technologically enhanced contexts, outlining major methodological difficulties pertaining to this sort of this grounded research.
Rewriting rural community and dictatorial history through magical realism in Márquez’s One Hundred Years of Solitude
Authors: Abdullah Abu Shahid 
Published: June 2015

Abstract
Márquez was greatly influenced by his grandmother’s story-telling ability, and was highly indebted to the socio-political history of Latin America, particularly Colombia. In One Hundred Years of Solitude, he wants to reconstruct the lost world of childhood by using magical realism which gives expression to the world-view of a rural people who live in isolation from modern world. By retelling the official history from the perspective of the oppressed, he reveals the fact that history is never factual and impartial but serves the interest of those who write it. Through the banana company massacre and the subsequent hide and seek over the number of dead workers, Márquez exposes the way official history becomes fabricated and distorted by authorities, and fails to provide the original occurrences. He was disgusted with the political violence and civil wars which had distraught people; he was also against capitalism, scientific and technological inventions, and so-called modernization, which are the means through which foreign culture brings corruption and brutality, dominates, exploits and oppresses the natives, and threatens the native culture and identity. By employing magical realism, he was able to recreate Colombian history to protest against the way capitalism dominated the socio-political and economic structure of the region.
What Can I Hope about the Earth’s Future Climate? Affective Resources for Overcoming Intergenerational Distance, Kantian and Otherwise
Authors: Williamson Diane 
Published: June 2015

Abstract
While climate change involves spatial, epistemological, social, and temporal remoteness, each type of distance can be bridged with strategies unique to it that can be borrowed from analogous moral problems. Temporal, or intergenerational, distance may actually be a motivational resource if we look at our natural feelings of hope for the future of the world, via Kant’s theory of political history, and for our children. Kant’s theory of hope also provides some basis for including future generations in a theory of justice.
État chimique de formé au cours de l’irradiatión neutronique de composés du tellure
Authors: Bertet Michel , Chanut Yves , Muxart Roland 
Published: June 2015

Résumé
Les transformations chimiques accompagnant l’émission β
-
de 131Te ont été étudiées dans différentes conditions expérimentales; on a recherché particuliérement les états d’oxydation 131I de après irradiation neutronique d’anhydride tellureux et d’acide tellurique cristallisés ou dissous dans divers milieux aqueux. Dans le cas de l’acide tellurique, les quantités relatives des états d’oxydation de 131I, fraction réduite (I*-, I*O-, I*2), iodates et périodates dépendent du milieu de dissolution, que l’acide soit irradié k l’état cristallisé ou en solution. Dans le premier cas, la fraction «réduite» croît de 12% a 89% lorsque l’on passe d’un milieu de dissolution voisin de la neutralité á un milieu acide (HNO3 0,8 M). Dans le second cas, la fraction «réduite» est de 89% en Solution neutre ou acide et 64% dans KOH 0,5 M. Pour l’anhydride tellureux, en milieu alcalin, la valeur de la fraction «réduite » varie peu avec les conditions d’irradiation de TeO2 (état solide ou dissous). En Solution, on observe seulement une légère augmentation (de 46% á 56%). Le milieu nitrique est, par contre, caractérisé par une très grande instabilité dont le résultat est une répartition variable des divers états d’oxydation de l’iode, suivant les conditions expérimentales d’analyse.
Extraction of Ruthenium by Naphthols from Fission Products Mixtures
Authors: Konečný Ctirad 
Published: June 2015

Summary
Separation of microamounts of ruthenium from fission product mixtures in 0.2-0.8 M•HNO3 by extraction with molten naphthols was studied with respect to the composition of individual mixtures and to naphthol amounts. The values of ruthenium distribution ratios depend on the molar ratios naphthol: ferric ions and naphthol: mercuric ions. The radionuclides 106Ru, 90Sr,144Ce, and 137CS were used for the test trials.