bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lanthanide Complexes Containing a Terminal LnIII−O Bond: Hydrolysis as a Tool to Assess f‐Element Bond Covalency
Authors: Shafi Ziad , Gibson John K. 
Published: July 2024

AbstractWe report the preparation, isolation, and reactivity of gas‐phase lanthanide nitrate and acetate complexes featuring the elusive trivalent LnIII=O bond. Complexes [LnIII(O)(X)2]− (X=NO3− or CH3CO2−; Ln=La, Ce, Pr, Nd, Sm, Eu, Tb, Dy, Tm, Lu) are prepared from [LnIII(CH3CO2)(X)3]− precursors through decarboxylation followed by nitromethane or acetone elimination. The oxo complexes hydrolyze at rates indicating LnIII=O bond stability. The rates for [LnIII(O)(NO3)2]− are essentially invariant, whereas those for [LnIII(O)(CH3CO2)2]− exhibit a moderate decrease across the lanthanide series. The kinetics of lanthanide‐oxo bond hydrolysis are assessed in the context of participation of 5d2 electrons in bonding, changes in covalency via variations in 5d orbital energies and radial extensions, and steric crowding around the lanthanide center. The observed fast hydrolysis rates and lack of correlation to electronic and qualitative covalent considerations confirm the expected strong polarization in LnIII=O bonding, with variations in covalency minimally impacting reactivity. The LnIII=O bond reactivity is compared with previous results for LnIII−O⋅ and LnIV=O, and actinide AnIII=O and AnIV=O; implications for lanthanide/actinide and lanthanide/lanthanide partitioning are discussed. Additionally, nitromethane and acetone elimination are demonstrated as useful for inducing a 2e− O‐atom transfer resulting in non‐oxidative formation of lanthanide‐oxos.
Exploration of Synthetic Potential of Quinoline‐3‐Carbaldehydes
Authors: Kumar Vipin , Sharma Shubham , Vaishali  , Singh Dharmender , Malakar Chandi C. , Singh Virender 
Published: July 2024

AbstractQuinoline is one of the most important nitrogen containing heterocycles, being widespread in nature and present in a broad variety of pharmacologically active compounds. Specifically, several quinoline based renowned antimalarial agents have served the mankind for several past decades and showed strong potential applications in other field also. 3‐Formyl‐quinoline is a versatile precursor which can be transformed using several easy methods into a wide range of biologically valuable scaffolds. The exploration of 3‐formyl‐quinolines have gained much more attention to medicinal chemists in the field of drug discovery to design and synthesize new fused/tethered quinolines as potent therapeutical agents. This manuscript summarizes the reports (from 2011 to 2023) which showing the synthetic potential of quinoline‐3‐carbaldehydes.
NaBH4‐Induced Chemoselective Mechanochemical Neat Synthesis of Bio‐Active Dihydrofuran/ϵ‐Hydroxy‐α,β‐Unsaturated Esters and Synthetic Application to Isoindoles
Authors: Barik Paritosh , Pal Chandan Kumar , Chakraborty Sudipta , Azad Sk Abulkalam , Patra Prasanta , Jana Rathin , Molla Mijanur Rahaman , Samanta Shubhankar 
Published: July 2024

AbstractThe synthesis of small heterocycles under neat mechanochemical conditions is of great interest in the field of drug design because most of the commercially available drugs contain at least one heterocyclic unit. The sodium borohydride (NaBH4) promoted reductive cyclization to fused dihydrofuran under grinding technique is one of the compendium additions for the clean future. The development of chemoselective reduction under silica‐gel supported conditions represents significant progress in organic synthesis, offering a versatile and efficient method for selective reduction of specific functional groups within complex molecules. Synthesis of isoindole derivatives from the chemoselective reduce product via a sustainable short synthetic pathway is another significant process of our newly developed protocol. Finally, antileishmanial investigations of our synthesized compounds establish a soft bridge between biology and chemistry.
Neuroinflammatory activation in sensory and motor regions of the cortex is related to sensorimotor function in individuals with low back pain maintained by nociplastic mechanisms: A preliminary proof‐of‐concept study
Authors: Shraim Muath A. , Massé‐Alarie Hugo , Farrell Michael J. , Cavaleri Rocco , Loggia Marco L. , Hodges Paul W. 
Published: July 2024

AbstractBackgroundChronic pain involves communication between neural and immune systems. Recent data suggest localization of glial (brain immune cells) activation to the sensorimotor regions of the brain cortex (S1/M1) in chronic low back pain (LBP). As glia perform diverse functions that impact neural function, activation might contribute to sensorimotor changes, particularly in LBP maintained by increased nervous system sensitivity (i.e., nociplastic pain). This preliminary proof‐of‐concept study aimed to: (i) compare evidence of neuroinflammatory activation in S1/M1 between individuals with and without LBP (and between nociceptive and nociplastic LBP phenotypes), and (ii) evaluate relationships between neuroinflammatory activation and sensorimotor function.MethodsSimultaneous PET‐fMRI measured neuroinflammatory activation in functionally defined S1/M1 in pain‐free individuals (n = 8) and individuals with chronic LBP (n = 9; nociceptive: n = 4, nociplastic: n = 5). Regions of S1/M1 related to the back were identified using fMRI during motor tasks and thermal stimuli. Sensorimotor measures included single and paired‐pulse transcranial magnetic stimulation (TMS) and quantitative sensory testing (QST). Sleep, depression, disability and pain questionnaires were administered.ResultsNeuroinflammatory activation was greater in the lower back cortical representation of S1/M1 of the nociplastic LBP group than both nociceptive LBP and pain‐free groups. Neuroinflammatory activation in S1/M1 was positively correlated with sensitivity to hot (r = 0.52) and cold (r = 0.55) pain stimuli, poor sleep, depression, disability and BMI, and negatively correlated with intracortical facilitation (r = −0.41).ConclusionThis preliminary proof‐of‐concept study suggests that neuroinflammation in back regions of S1/M1 in individuals with nociplastic LBP could plausibly explain some characteristic features of this LBP phenotype.Significance StatementNeuroinflammatory activation localized to sensorimotor areas of the brain in individuals with nociplastic pain might contribute to changes in sensory and motor function and aspects of central sensitization. If cause–effect relationships are established in longitudinal studies, this may direct development of therapies that target neuroinflammatory activation.
Optimization method for capacity of BESS considering charge‐discharge cycle and renewable energy penetration rate
Authors: Zhao Yu , Luo Zhongge , Zhang Yi , Wu Mengjing , Wen Li , Li Gen 
Published: July 2024

AbstractIn order to achieve the “carbon peaking and carbon neutrality” goals, we must vigorously develop renewable energy power generation. As the penetration of renewables progressively escalates, the corresponding demand for battery energy storage systems (BESS) within the power grid rises concomitantly. This paper presents an innovative optimization approach for configuring BESS, taking into account the incremental variations in renewable energy penetration levels and BESS charge‐discharge cycles. Employing incremental analytical techniques and pivotal metrics such as capacity elasticity, the proposed method determines the optimal penetration rate and corresponding BESS capacity outcomes for deploying energy storage systems. An example analysis of a rural power distribution benchmark is carried out by using the method in this paper, which proves the effectiveness of the method in this paper. This methodology was substantiated through its application to a case study of a rural power distribution benchmark, thereby validating its efficacy. Furthermore, it was compared with the particle swarm optimization, providing a comparative assessment of their relative performance.
Structural and molecular characterization of astrocyte and vasculature connectivity in the mouse hippocampus and cortex
Authors: Lorin Charlotte , Guiet Romain , Chiaruttini Nicolas , Ambrosini Giovanna , Boci Elvis , Abdellah Marwan , Markram Henry , Keller Daniel 
Published: July 2024

AbstractThe relation of astrocytic endfeet to the vasculature plays a key functional role in the neuro‐glia‐vasculature unit. We characterize the spatial organization of astrocytes and the structural aspects that facilitate their involvement in molecular exchanges. Using double transgenic mice, we performed co‐immunostaining, confocal microscopy, and three‐dimensional digital segmentation to investigate the biophysical and molecular organization of astrocytes and their intricate endfoot network at the micrometer level in the isocortex and hippocampus. The results showed that hippocampal astrocytes had smaller territories, reduced endfoot dimensions, and fewer contacts with blood vessels compared with those in the isocortex. Additionally, we found that both connexins 43 and 30 have a higher density in the endfoot and the former is overexpressed relative to the latter. However, due to the limitations of the method, further studies are needed to determine the exact localization on the endfoot. The quantitative information obtained in this study will be useful for modeling the interactions of astrocytes with the vasculature.
Efficacy and safety of proton therapy versus intensity‐modulated radiation therapy in the treatment of head and neck tumors: A systematic review and meta‐analysis
Authors: Vasudevan Srivatsa Surya , Deeb Haya , Katta Anuhya , Olinde Lindsay , Pang John , Asarkar Ameya A. , Katz Sanford , Nathan Cherie‐Ann O. 
Published: July 2024

AbstractTo comprehensively evaluate the therapeutic efficacy and safety when utilizing proton therapy (PT) versus intensity‐modulated radiation therapy (IMRT) in head and neck cancer patients. Pubmed, ScienceDirect, Embase, Scopus, and Web of Science were systematically searched for studies on comparative PT and IMRT outcomes. We performed a random effect model meta‐analysis to estimate the hazard ratio (HR) and odds ratio (OR) for efficacy and safety outcome variables between PT and IMRT. From 641 identified articles, 11 studies met the inclusion criteria, comprising 3087 patients (606 treated with PT and 2481 with IMRT). On toxicity analysis, PT is associated with decreased acute grade 1 nausea (OR = 0.34, 95% CI: 0.13–0.84, p = 0.02) compared to IMRT. In grade 2 toxicity, PT showed significant advantages over IMRT in mucositis (OR = 0.44, p < 0.0001), dysgeusia (OR = 0.35, p = 0.02), dysphagia (OR = 0.36, p < 0.0001), fatigue (OR = 0.29, p = 0.001), pain (OR = 0.34, p = 0.01), and weight loss (OR = 0.54, p = 0.02). Proton therapy also exhibited increased safety in grade 3 dysphagia incidence (OR = 0.44, p < 0.0001) compared to IMRT. PT demonstrated improved overall survival (OS) compared to IMRT across multiple time points: 1‐year OS (HR = 0.43, p = 0.02), 2‐year OS (HR = 0.44, p < 0.0001), and 5‐year OS (HR = 0.78, p = 0.004). In terms of disease‐free survival (DFS), PT also showed improved outcomes at 2‐year DFS (HR = 0.65, p = 0.03) and 5‐year DFS (HR = 0.81, p = 0.03). Proton therapy demonstrated superior overall survival (OS), disease‐free survival (DFS), and better local control rate (LCR) compared to IMRT. The data also showed better safety outcomes in PT patients, particularly when involving grade 2 acute toxicity events.
“Something we must be proud of”: An interview and document study of team improvisation in the Dutch convalescent plasma project group
Authors: Langi Sasongko Praiseldy , Vrielink Hans , de Bruijne Martine 
Published: July 2024

AbstractBackground and AimsThe COVID‐19 pandemic has revealed the importance of organizational resilience, the ability to effectively respond to a disruptive event before, during, and after it occurs. Team improvisation is an important component of organizational resilience as it describes characteristics of team skills and contextual qualities to create order from chaos. In Spring 2020, the Dutch national blood bank, began the convalescent plasma project (CCP). We aimed to study which elements of team improvisation in the CCP group were found and how lessons learned can contribute towards a non‐crisis situation for blood establishments.MethodsUsing Vera and Crossan's framework of improvisation, semi‐structured interviews with eight members of the CCP group were conducted. This was simultaneous to performing a document analysis of 21 Intranet posts and seven internal reports. MAXDA 2020 was used to conduct deductive and inductive thematic analyses.ResultsThe CCP group showed strong characteristics of expertise and memory, teamwork quality, experimental culture, and real‐time information and communication that enabled them to improvise in all aspects of the donation process. Improvisation examples included comprehensive communication methods to identify and obtain new donors, asking additional intake questions and collecting additional aliquots to store while waiting for an internal antibody test to be developed, and regulatory respondents allowing a flexible change control procedure to meet the pace of the crisis. Training was evident to a lesser degree.ConclusionWhile improvisation impacted set routines and procedures, the safety and quality of the product were not affected. Regarding organizational resilience, our results showed that the CCP group “coped” well using elements of team improvisation. Blood establishments may consider introducing improvisational training and innovation teams throughout the organization for future preparedness and improving organizational resilience.
Numerical simulation of an impinging jet array in a square channel covered by a porous layer
Authors: Khademi Saeed , Bazargan Majid 
Published: July 2024

AbstractIn many heat transfer applications, the design of the flow field should warrant high heat transfer rates and, meanwhile, reduce the thermal stresses so that hot spots along the heat transfer surface be avoided. A combination of multiple jets impinging on a channel bed together with the surface covered by a porous layer is proposed to satisfy both objectives in the current study. A three‐dimensional numerical simulation using a finite volume method with the second‐order discretization has been applied to visualize the multiple‐impinging jet flow behavior. The impacts of the porous medium parameters, including the thickness, permeability, and porosity, on the magnitude and distribution of the heat transfer along the channel bed have been evaluated. It is shown that the overall heat transfer performance of the proposed flow is significantly improved in comparison with the conventional case of the fluid flowing parallel to the channel bed. The presence of the porous layer leads to a more even spread of the fluid on the target surface, which reduces the thermal stresses and prevents the large differences between the highest and lowest values of heat transfer coefficients. They also found that both the porosity and particularly the permeability of the porous layer enhance the effect of the crossflow along the flow associated with the multiple‐impinging jet setup. For a certain thickness of the porous layer, it is possible to reduce the amplitude of the Nusselt number oscillations effectively, while keeping the overall Nusselt number desirably high.
Effect of maternal obsessive‐compulsive disorder (OCD) on feto‐maternal outcomes: A systematic review and meta‐analysis
Authors: Aujla Savvy , Sandeep Mokanpally , Aparnavi Periasamy , Padhi Bijaya Kumar , Shamim Muhammad Aaqib , Sahoo Swapnajeet , Gangane Neha , Gandhi Aravind P 
Published: July 2024

AbstractBackgroundMental health disorders in pregnant women have been related to unfavorable obstetric and neonatal outcomes. Obsessive‐compulsive disorder (OCD) significantly distresses mothers and affects the maternal–infant bond.ObjectivesThe present meta‐analysis and systematic review aimed to assess the association of maternal OCD with adverse feto‐maternal outcomes.Search StrategyA systematic search was undertaken in the five databases—Cochrane, Embase, ProQuest, Web of Science, and PubMed—on September 5, 2023.Selection CriteriaStudies that included pregnant women with OCD in whom the feto‐maternal outcomes were reported were included in the systematic review.Data Collection and AnalysisTwo pass screening (“title‐abstract screening” followed by “full‐text review”), and data extraction by two authors independently using the Nested‐Knowledge Auto living semi‐automated systematic review platform was carried out. The decision for selected studies was reviewed by a third author. Of the 360 studies identified, eight were included for the meta‐analysis. Meta‐analysis was conducted using R software.Main ResultsOf the 24 maternal and neonatal adverse outcomes assessed, 11 were found to be associated with maternal OCD, notably pre‐eclampsia (odds ratio [OR] 1.37, 95% confidence interval [CI] 1.19–1.57), antepartum hemorrhage or placental abruption (OR 1.32, 95% CI 1.13–1.54), postpartum hemporrhage (OR 1.19, 95% CI 1.08–1.31), cesarean section delivery (OR 1.32, 95% CI 1.23–1.41), emergency cesarean section (OR 1.22, 95% CI 1.15–1.30), preterm birth (OR 1.41, 95% CI 1.21–1.64), low birth weight (OR 1.41, 95% CI 1.28–1.54), low Apgar score at 5 min (OR 2.37, 95% CI 1.32–4.27), neonatal hypoglycemia (OR 1.37, 95% CI 1.23–1.53), neonatal respiratory distress (OR 1.77, 95% CI 1.44–2.16), and major congenital malformations (OR 1.37, 95% CI 1.08–1.74).ConclusionOCD in pregnant women might be associated with multiple adverse feto‐maternal outcomes.
Demographic and net primary productivity dynamics of primary and secondary tropical forests in Southwest China under a changing climate
Authors: Oo Sai Tun Tun , Panthi Shankar , Fan Ze‐Xin , Song Xiao‐Yang , Zhang‐Zheng Huanyuan , Zaw Zaw , Lu Hua‐Zheng , Chen Hui , Deng Yun , Zhao Rong , Lin Hua , Fu Pei‐Li 
Published: July 2024

AbstractTropical forests are major carbon sinks on the Earth's land surface. However, our understanding of how the demographic rate and carbon sink capacities of tropical forests respond to climate change remains limited. In this study, we investigated the impacts of environmental drivers on forest growth, mortality, recruitment, and stem net primary productivity (NPPstem) over 16 years at five tropical forest plots in Xishuangbanna, Southwest China. These plots are along a successional gradient spanning three tropical secondary forests (tropical secondary forest‐1 [TSF‐1], tropical secondary forest‐2 [TSF‐2], and tropical secondary forest‐3 [TSF‐3]) and two primary forests (tropical rainforest [TRF] and tropical karst forest [TKF]). Our results showed that early successional secondary forests (TSF‐2 and TSF‐3) had higher diameter growth rates and relative mortality rates. An extreme drought event during 2009–2010 reduced the growth rate, relative recruitment rate, and NPPstem for most plots while increasing mortality in early successional forest plots. We observed significant negative effects of maximum temperature (Tmax) on NPPstem and diameter growth rate across all plots. Additionally, we found that precipitation had significant positive effects on diameter growth rate across all plots. Furthermore, tree mortality increased with rising Tmax, whereas precipitation significantly enhanced tree recruitment. Our findings highlight the vulnerability of tree growth, mortality, recruitment, and productivity in tropical forests to extreme drought events in Southwest China. Continued climate warming and more frequent droughts will induce higher mortality rates and impede growth, thus reducing the carbon sink capacity of tropical forests, especially in early successional stage tropical secondary forests.
Activity theory perspective to the scale‐up and sustainability of mhealth in armed conflict zones of developing countries
Authors: David Nakama , Tyndall Jennifer 
Published: July 2024

AbstractMobile Health (mHealth) presents the potential to facilitate healthcare and improve the quality of life if successful pilot projects are scaled up and sustainable. However, the persistent termination of mHealth at the pilot phase challenges its potential in developing countries. Existing research suggests an absence of understanding of these phenomena for two reasons. First, literature is scarce in the broad context of armed conflict zones in developing countries, particularly in the IS domain. Second, extant literature emphasizes mHealth implementation, while neglecting the scale‐up and sustainability of these technologies. Therefore, this study employs activity theory as a holistic lens to explore how contradictions shape the scale‐up and sustainability of mHealth in the armed conflict zone of developing countries. In this study, rather than viewing contradiction as a challenge, it serves as a driver for effecting changes that can foster scale‐up and sustainability. The Algorithm for the Management of Acute Childhood Illnesses (ALMANACH), provides an empirical basis for this study. The research employs the interpretivism philosophy and the case study method. In‐depth interviews, participatory observations, and document reviews were used to collect data. Purposive and snowball sampling techniques were used to select the study's participants. The study reveals a lack of professional expertise among the CHWs, the non‐involvement of the users and beneficiaries in designing ALMANACH, and the lack of financial compensation for using ALMANACH in practice as contradictions. The study further exposes how community volunteer groups and the ALMANACH scientific board were established to steer demand.
Let‑7f‑5p Regulated by Hsa_circ_0000437 Ameliorates Bleomycin‐Induced Skin Fibrosis
Authors: Liu Baiting , Li Chenxi , Bo Yunyao , Tian Guiping , Yang Lijun , Si Jianjun , Zhang Lin , Yan Yuan 
Published: July 2024

ABSTRACTThe current treatment of skin fibrosis is limited in its effectiveness due to a lack of understanding of the underlying mechanisms. Previous research has shown a connection between microRNAs (miRNAs) and the development of skin fibrosis. Therefore, investigating miRNA for the treatment of skin fibrotic diseases is highly important and merits further exploration. In this study, we have discovered that let‐7f‐5p could suppress the proliferation, migration, and expression of collagen type I alpha 1 (COL1A1) in human dermal fibroblasts (HDFs). It was further determined that let‐7f‐5p could target thrombospondin‐1 (THBS1), thereby inhibiting the TGF‐β2/Smad3 signaling pathway and exerting its biological effects. Additionally, let‐7f‐5p is regulated by Hsa_circ_0000437, which acts as a sponge molecule for let‐7f‐5p and consequently regulates the biological function of HDFs. Furthermore, our findings indicate that in vivo overexpression of let‐7f‐5p leads to a reduction in dermal thickness and COL1A1 expression, effectively inhibiting the progression of bleomycin (BLM)‐induced skin fibrosis in mice. Hence, our research enhances the comprehension of the Hsa_circ_0000437/let‐7f‐5p/THBS1/TGF‐β2/Smad3 regulatory network, highlighting the potential of let‐7f‐5p as a therapeutic approach for the treatment of skin fibrosis.