bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Decoration of Sulfur with Porous Metal Nanostructures: An Alternative Strategy for Improving the Cyclability of Sulfur Cathode Materials for Advanced Lithium—Sulfur Batteries.
Authors: Tao Xinyong , Chen Feng , Xia Yang , Huang Hui , Gan Yongping , Chen Xiaorong , Zhang Wenkui 
Published: July 2013

AbstractPt@S nanostructures are prepared from mixtures of pristine sulfur microparticles (obtained from aqueous mixtures of sodium polysulfide, ZnCl2, and H2O2), aqueous H2PtCl6, and NaBH4 solutions.
ChemInform Abstract: Germanium Sulfide (II and IV) Nanoparticles for Enhanced Performance of Lithium Ion Batteries.
Authors: Park Jeunghee , et al. et al. 
Published: July 2013

AbstractCrystalline, orthorhombic GeS and GeS2 nanoparticles are synthesized by gas phase laser photolysis of stoichiometric mixtures of GeMe4 and H2S followed by thermal annealing at 350 °C for 0.5—2 h.
ChemInform Abstract: Cu2(OH)PO4, a Near‐Infrared‐Activated Photocatalyst.
Authors: Wang Gang , Huang Baibiao , Ma Xiangchao , Wang Zeyan , Qin Xiaoyan , Zhang Xiaoyang , Dai Ying , Whangbo Myung‐Hwan 
Published: July 2013

AbstractMicrocrystals of the title compound are hydrothermally prepared from aqueous solutions of stoichiometric amounts of Cu(NO3)2 and Na2HPO4 (pH 7, autoclave, 120 °C, 6 h).
ChemInform Abstract: Ln3FeGaQ7: A New Series of Transition‐Metal Rare‐Earth Chalcogenides.
Authors: Yin Wenlong , Wang Wendong , Kang Lei , Lin Zheshuai , Feng Kai , Shi Youguo , Hao Wenyu , Yao Jiyong , Wu Yicheng 
Published: July 2013

AbstractThe compounds Ln3FeGaQ7 (Ln: Nd, Sm, Gd, Dy, Q: S; Ln: Nd, Gd, Dy, Q: Se) are prepared by solid state reactions of Ln, Fe, Ga2Q3, and Q (sealed silica tube, 1323—1373 K, 48 h).
ChemInform Abstract: Suppression of Intersite Charge Transfer in Charge‐Disproportionated Perovskite YCu3Fe4O12.
Authors: Yamada Ikuya , et al. et al. 
Published: July 2013

AbstractThe new title perovskite is synthesized from a mixture of YCu3Fe4O10.5 and KClO4 (Pt capsule, 15 GPa, 1273 K, 30 min).
ChemInform Abstract: Catalytic Asymmetric Cross‐Dehydrogenative Coupling: Activation of C—H Bonds by a Cooperative Bimetallic Catalyst System.
Authors: Cao Weidi , Liu Xiaohua , Peng Ruixue , He Peng , Lin Lili , Feng Xiaoming 
Published: July 2013

AbstractA combination of nickel and iron salts with a chiral proline‐derived N,N′‐dioxide ligand is an efficient catalytic system for the asymmetric cross‐dehydrogenative coupling of cyclic β‐ketoesters with xanthene.
ChemInform Abstract: A Study on the Substituent Effects of Norbornadiene Derivatives in Iridium‐Catalyzed Asymmetric [2 + 2] Cycloaddition Reactions.
Authors: Hu Jun , Yang Qingjing , Yu Lu , Xu Jianbin , Liu Shanshan , Huang Chao , Wang Lin , Zhou Yongyun , Fan Baomin 
Published: July 2013

AbstractEmploying a series of norbornadiene derivatives as substrates, the effects of various substituents on the Ir‐catalyzed [2 + 2] cycloaddition reactions with arylacetylenes are studied.
ChemInform Abstract: Catalytic Oxidative 1,2‐Shift in 1,1′‐Disubstituted Olefins Using Arene(iodo)sulfonic Acid as the Precatalyst and Oxone as the Oxidant.
Authors: Purohit Vikram C. , Allwein Shawn P. , Bakale Roger P. 
Published: July 2013

AbstractThe new methodology provides concise access to homobenzylic ketones with electron‐donating substituents from disubstituted olefins (IV).
ChemInform Abstract: The Use of Ultrasmall Iron(0) Nanoparticles as Catalysts for the Selective Hydrogenation of Unsaturated C—C Bonds.
Authors: Kelsen Vinciane , Wendt Bianca , Werkmeister Svenja , Junge Kathrin , Beller Matthias , Chaudret Bruno 
Published: July 2013

AbstractMonodisperse iron nanoparticles of about 2 nm size are prepared and tested as a heterogeneous catalyst in the hydrogenation of alkenes, dienes, and alkynes.
ChemInform Abstract: Mild and Convenient N‐Formylation Protocol in Water‐Containing Solvents.
Authors: Aleiwi Bilal A. , Mitachi Katsuhiko , Kurosu Michio 
Published: July 2013

AbstractA new protocol is developed for the N‐formylation of amines and amino acids with formic acid in the presence of water‐soluble peptide coupling additives.
ChemInform Abstract: Chemoselective Alkynylation of N‐Sulfonylamides versus Amides and Carbamates — Synthesis of Tetrahydropyrazines.
Authors: Aubineau Thomas , Cossy Janine 
Published: July 2013

AbstractBenziodoxol (II) is found to be a good and chemoselective alkynylating reagent for N‐tosyl amides, such as (I), (IV) and (VI).
ChemInform Abstract: Chiral NCN Pincer Rhodium(III) Complexes with Bis(imidazolinyl)phenyl Ligands: Synthesis and Enantioselective Catalytic Alkynylation of Trifluoropyruvates with Terminal Alkynes.
Authors: Wang Tao , Niu Jun‐Long , Liu Shuang‐Liang , Huang Juan‐Juan , Gong Jun‐Fang , Song Mao‐Ping 
Published: July 2013

AbstractThe new chiral title catalyst can be applied to the synthesis of a wide range of different substituted and optically active propargylic alcohols.
ChemInform Abstract: Organocatalytic Alkynylation of Densely Functionalized Monofluorinated Derivatives: C(sp3)—C(sp) Coupling.
Authors: Kamlar Martin , Putaj Piotr , Vesely Jan 
Published: July 2013

AbstractThe alkynylation of nucleophilic fluorocarbons (II) with hypervalent iodine compound (I) is developed using a cinchona alkaloid derivative as catalyst.
ChemInform Abstract: Whole Cells in Enantioselective Reduction of tert‐Butyl Acetoacetate.
Authors: Ramos Aline de Souza , Ribeiro Joyce Benzaquem , Lopes Raquel de Oliveira , de Souza Rodrigo Octavio Mendonca Alves 
Published: July 2013

AbstractSeveral microorganism strains are tested in the enantioselective reduction of tert‐butyl acetoacetate.
ChemInform Abstract: Synthesis of N,N′‐Disulfonylamidines from Sulfonamides and Alkynes by a Two‐Step, One‐Pot Reaction with Nonafluorobutanesulfonyl Azide.
Authors: Suarez Jose Ramon , Kwiczak Joanna , Grenda Katarzyna , Jimeno M. Luisa , Chiara Jose Luis 
Published: July 2013

AbstractThe novel and simple title reaction affords the different substituted products (IV) and (VI) from available sulfonamides.
ChemInform Abstract: Reductive Alkylation of Bis(triflyl)methane Through Self‐Promoting Formation of Easily Isolable 1,1‐Bis(triflyl)alkenes.
Authors: Yanai Hikaru , Egawa Saki , Taguchi Takeo 
Published: July 2013

AbstractSelf‐promoting condensation of title agent (II) with α,β‐unsaturated aldehydes (I) provides dienes (III), whereas aliphatic aldehydes (VII) give unusual β,γ‐unsaturated sulfones (VIII) as the major products.
ChemInform Abstract: Stereoselective Cyclopropanation of α‐Bromochalcone with Diethyl Malonate Promoted by K2CO3.
Authors: Sun Yongxian , Yang Gaosheng , Shen Yue , Hua Zan , Chai Zhuo 
Published: July 2013

AbstractBesides good yields for the exclusive formation of the trans‐isomers (III), this Michael‐initiated ring closure reaction also provides the first access to the cis‐isomers (IV) of the depicted densely substituted cyclopropanes.
ChemInform Abstract: Iron‐Catalyzed Direct Alkenylation of sp3(C—H) Bonds via Decarboxylation of Cinnamic Acids under Ligand‐Free Conditions.
Authors: Yang Hailong , Yan Hong , Sun Peng , Zhu Yan , Lu Linhua , Liu Defu , Rong Guangwei , Mao Jincheng 
Published: July 2013

AbstractA novel ferrocene‐catalyzed decarboxylative C(sp2)—C(sp3) coupling reaction via C—H functionalization is developed.
ChemInform Abstract: An Expedient and Green Protocol for the Michael Addition of Malonates, Diketones and β‐Keto Esters to the Nitrostyrenes.
Authors: Agarwal Jyoti , Naganaboina Ram Tilak , Peddinti Rma Krishna 
Published: July 2013

AbstractA novel method for the rapid synthesis of functionalized nitroalkanes by addition of less reactive carbon nucleophiles to various trans‐β‐nitrostyrenes under solvent‐free reaction conditions is developed.
ChemInform Abstract: Polymer‐Supported L‐Prolinol‐Based Catalysts for the Enantioselective Addition of Dialkylzinc Reagents to N‐(Diphenylphosphinyl)imines.
Authors: Almansa Raquel , Collados Juan F. , Guijarro David , Yus Miguel 
Published: July 2013

AbstractThe polymeric ligand can be recovered and reused up to six times without significant loss of activity.
ChemInform Abstract: Novel Method of Synthesis of Quaternary Ammonium Tribromides and Investigation of Catalytic Role of Benzyltrimethylammonium Tribromide in Oxidation of Alcohols to Carbonyl Compounds.
Authors: Dey Madhudeepa , Dhar Siddhartha Sankar , Kalita Mukul 
Published: July 2013

AbstractBenzyltrimethylammonium tribromide is used as an efficient catalyst for the oxidation of primary and secondary alcohols to the corresponding carbonyl compounds.
ChemInform Abstract: Synthesis of 2‐Chloro‐3‐oxoesters by Reaction of the Dianion of Ethyl 2‐Chloroacetoacetate with Electrophiles.
Authors: Specowius Verena , Rahn Thomas , Adeel Muhammad , Reim Stefanie , Feist Holger , Saghyan Ashot S. , Langer Peter 
Published: July 2013

AbstractTitle compounds [(III), (V), and (VII)] as well as 2‐alkylidenetetrahydrofuran (IX) are synthesized by regioselective reaction of the dianion of ester (I) with halides [(II), (IV), or (VIII)] or aldehydes (VI), respectively.
ChemInform Abstract: Palladium Nanoparticles Immobilized on Nano‐Silica Triazine Dendritic Polymer (Pdnp‐nSTDP): An Efficient and Reusable Catalyst for Suzuki—Miyaura Cross‐Coupling and Heck Reactions.
Authors: Isfahani Amir Landarani , Mohammadpoor‐Baltork Iraj , Mirkhani Valiollah , Khosropour Ahmad R. , Moghadam Majid , Tangestaninejad Shahram , Kia Reza 
Published: July 2013

AbstractThe new title catalyst shows high activity for the Suzuki‐Miyaura cross‐coupling and the Heck reaction by using low loadings.
ChemInform Abstract: Regiocontrolled Hydroarylation of (Trifluoromethyl)acetylenes in Superacids: Synthesis of CF3‐Substituted 1,1‐Diarylethenes.
Authors: Alkhafaji Haider M. H. , Ryabukhin Dmitry S. , Muzalevskiy Vasiliy M. , Vasilyev Aleksander V. , Fukin Georgy K. , Shastin Alexey V. , Nenajdenko Valentine G. 
Published: July 2013

AbstractVinyl cations are generated from aryl(trifluoromethyl)acetylenes using superacids such as TfOH or FSO3H.
ChemInform Abstract: A Rapid Approach Toward Synthesis of 1,3,5‐Triarylpent‐2‐ene‐1,5‐diones Catalyzed by KF/Al2O3 and PEG‐400 Using Microwave Irradiation.
Authors: Song Mingzhi , Fan Chuangang 
Published: July 2013

AbstractA fast and environmentally benign approach for the transformation of triarylpyrylium salts to 1,3,5‐triarylpent‐5‐ene‐1,5‐diones under microwave irradiation is presented.
ChemInform Abstract: Phosphine‐Free Palladium‐Catalyzed Decarboxylative Coupling of Alkynylcarboxylic Acids with Aryl and Heteroaryl Halides.
Authors: Reddy Police Vishnuvardhan , Srinivas Pottabathula , Annapurna Manne , Bhargava Suresh , Wagler Jorg , Mirzadeh Nedaossadat , Kantam Mannepalli Lakshmi 
Published: July 2013

AbstractThe applied catalyst is prepared in three steps.
ChemInform Abstract: Palladium(II)‐Catalyzed Synthesis of Functionalized Indenones via Oxidation and Cyclization of 2‐(2‐Arylethynylphenyl)acetonitriles.
Authors: Chen Xuxing , He Qian , Xie Yuyuan , Yang Chunhao 
Published: July 2013

AbstractA facile one‐pot two‐step synthesis of functionalized indenones [cf.
ChemInform Abstract: Direct Asymmetric Aldol Addition—Isomerization of α,β‐Unsaturated γ‐Butyrolactam with Aryl α‐Ketoesters: Synthesis of MBH‐Type Products.
Authors: Zhang Jinlong , Liu Xihong , Ma Xiaojuan , Wang Rui 
Published: July 2013

AbstractThe title reaction affords Morita—Baylis—Hillman type adducts containing a quaternary stereocenter in high yields and with excellent enantioselectivities.
ChemInform Abstract: Friedel—Crafts Alkylation of Natural Amino Acid‐Derived Pyrroles with CF3‐Substituted Cyclic Imines.
Authors: Shmatova Olga I. , Shevchenko Nikolay E. , Balenkova Elizabeth S. , Roeschenthaler Gerd‐Volker , Nenajdenko Valentine G. 
Published: July 2013

AbstractThe reaction of natural amino acid‐derived pyrroles of type (I) with CF3‐substituted cyclic imines of type (II) proceeds selectively at the β‐position of the pyrrole moiety.
ChemInform Abstract: An Eco‐Benign and Highly Efficient Access to 3‐Heterocyclic‐Substituted Isoindolinones in Ammonia Water.
Authors: Shen Shao‐Chun , Sun Xing‐Wen , Lin Guo‐Qiang 
Published: July 2013

AbstractTitle compounds (III), (V), (VII), and (IX) are prepared via three‐component reaction of 2‐formyl benzoic acid (II), ammonia, and coumarin (I)/(IV) or indole derivatives (VI)/(VIII).
ChemInform Abstract: KHSO4‐Assisted Michael Addition—Elimination Reactions of Indole with 3‐Dimethylamino‐1‐phenylprop‐2‐en‐1‐ones in Water: An Environmentally Friendly Synthesis of Novel 3‐Indolylchalcones.
Authors: Devi A. Satyapati , Helissey P. , Nongkhlaw R. L. , Vishwakarma Jai N. 
Published: July 2013

AbstractThe KHSO4‐assisted Michael addition‐elimination reaction of indoles of type (I) with (II) is described.
ChemInform Abstract: A Short, Novel, and Practical Synthesis of 3‐Alkenylated Indoles.
Authors: Kargar Mojgan , Hekmatshoar Rahim , Mostashari Abdol Jalil 
Published: July 2013

AbstractThe alkenylation of 2‐methylindole (I) and indole (VI) via acid‐mediated Michael addition‐elimination reaction with (II) is studied.
ChemInform Abstract: Recyclable Copper Catalyzed Nitrogenation of Biphenyl Halides: A Direct Approach to Carbazoles.
Authors: Ou Yang , Jiao Ning 
Published: July 2013

AbstractA novel method is reported for the synthesis of carbazoles (II) from biphenyl halides (I) and sodium azide in the presence of a recyclable heterogeneous catalyst prepared from cuprous iodide and Amberlyst A‐21 resin.
ChemInform Abstract: Synthesis of Di‐ and Tri‐Substituted Imidazole‐4‐carboxylates via PBu3‐Mediated [3 + 2] Cycloaddition
Authors: Hsu Mei‐Yuan , Dietrich Justin , Hulme Christopher , Shaw Arthur Y. 
Published: July 2013

Abstractof Δ2‐oxazoline generated in situ from amidoacetic acids (I) and cyanoformate (II)
ChemInform Abstract: Multistep Divergent Synthesis of Benzimidazole Linked Benzoxazole/Benzothiazole via Copper Catalyzed Domino Annulation.
Authors: Liao Jen‐Yu , Selvaraju Manikandan , Chen Chih‐Hau , Sun Chung‐Ming 
Published: July 2013

AbstractBenzimidazole linked ortho‐chloroamines (I), synthesized from 4‐fluoro‐3‐nitrobenzoic acid, react with various acid chlorides (II) and isothiocyanates (IV) forming ortho‐chloro anilides or thioureas, respectively.
ChemInform Abstract: A Pd(II)‐Catalyzed Asymmetric Approach Toward Chiral [3.3.1]‐Bicyclic Ketals Using 2‐Hydroxyphenylboronic Acid as a Pro‐Bis(nucleophile).
Authors: Wang Feijun , Chen Feng , Qu Mingliang , Li Teng , Liu Yunlong , Shi Min 
Published: July 2013

AbstractThe first enantioselective synthesis of title compounds (III), (V) and (VII) by a Pd‐catalyzed cascade reaction employing a 2‐hydroxyphenyl Pd‐complex as a bis(nucleophile) generated in situ via transmetallation of boronic acid (II).
ChemInform Abstract: Convenient One‐Pot Synthesis of Chromone Derivatives and Their Antifungal and Antibacterial Evaluation.
Authors: Abdel Ghani Sherif B. , Mugisha Patrick J. , Wilcox Juliet C. , Gado Emad A. M. , Medu Erere O. , Lamb Andew J. , Brown Richard C. D. 
Published: July 2013

AbstractThe title compounds (III) are obtained in one‐pot via esterification of 2‐hydroxyacetophenones (I) with various aliphatic or aromatic acid chlorides (II) and subsequent Baker—Venkataraman rearrangement.
ChemInform Abstract: Synthesis of Piperidin‐4‐ones Starting from 2‐(2‐Bromo‐1,1‐dimethylethyl)‐azetidines and 2‐(2‐Mesyloxyethyl)azetidines Through a Ring Expansion—Oxidation Protocol.
Authors: Mollet Karen , D'hooghe Matthias , Broeckx Leen , Danneels Barbara , Desmet Tom , De Kimpe Norbert 
Published: July 2013

AbstractFor the first time the full conversion of functionalized azetidines into piperidin‐4‐ones is reported.
ChemInform Abstract: Synthesis, Photochromism, and Effects of Metal Ions on Fluorescence of Dithienylethenes Containing Imidazo[2,1‐a]isoquinoline.
Authors: Li Sisi , Li Ziyong , Huang Shuyuan , Yin Jun , Liu Sheng Hua 
Published: July 2013

AbstractThe photochromism of the title compounds (III) indicates that they can easily isomerize between ring‐open and ring‐closed isomers upon irradiation with ultraviolet or visible light in CH2Cl2.
ChemInform Abstract: Synthesis of Imidazo and Benzimidazo[2,1‐a]isoquinolines by Rhodium‐Catalyzed Intramolecular Double C—H Bond Activation.
Authors: Reddy Vutukuri Prakash , Iwasaki Takanori , Kambe Nobuaki 
Published: July 2013

AbstractThe presented method describes a novel rhodium‐catalyzed intramolecular oxidative cross‐coupling reaction via double C‐H bond cleavage.
ChemInform Abstract: Regioselective C2‐Arylation of Imidazo[4,5‐b]pyridines.
Authors: Macdonald Jonathan , Oldfield Victoria , Bavetsias Vassilios , Blagg Julian 
Published: July 2013

AbstractAn efficient C2‐functionalization via direct C‐H arylation of N3‐Mem‐protected imidazo[4,5‐b]pyridines is described.
ChemInform Abstract: Iodine‐Catalyzed Aza‐Prins Cyclization: Metal‐Free Synthesis and Antiproliferative Activity of Hexahydrobenzo[f]isoquinolines.
Authors: Figueiredo Carlos A. M. , Reddy K. R. Kishore K. , Monteiro Paula A. , de Carvalho Joao E. , Ruiz Ana L. T. G. , Silva Luiz F. Jr. 
Published: July 2013

AbstractReaction of the homoallylic amine derivative (I) with different aldehydes produces the title compounds generally as mixtures of diastereomers.
ChemInform Abstract: Microwave Assisted Nano (ZnO—TiO2) Catalyzed Synthesis of Some New 4,5,6,7‐Tetrahydro‐6‐( (5‐substituted‐1,3,4‐oxadiazol‐2‐yl)methyl)thieno[2,3‐c]pyridine as Antimicrobial Agents.
Authors: Sangshetti Jaiprakash N. , Dharmadhikari Priyanka P. , Chouthe Rashmi S. , Fatema Bibi , Lad Vishal , Karande Vikram , Darandale Sunil N. , Shinde Devanand B. 
Published: July 2013

AbstractAmong the title compounds synthesized, derivatives (IIIb), (IIId), (IIIe), and (IIIg) show promising antimicrobial activities.
ChemInform Abstract: Synthesis of Phthalazinones via Palladium(II)‐Catalyzed Intramolecular Oxidative C—H/C—H Cross‐Coupling of N′‐Methylenebenzohydrazides.
Authors: Matsuda Takanori , Tomaru Yuki , Matsuda Yoshiya 
Published: July 2013

AbstractThe reaction is significantly sensitive to both electronic and steric effects and only applicable to hydrazide substrates; the cyclization fails without carbonyl function.
ChemInform Abstract: Synthesis of 7H‐Thiopyrano[2,3‐d]pyrimidines by Hydrobromic Acid‐Mediated Cyclization of 1‐[4‐(1,1‐Dimethylethylsulfanyl)pyrimidin‐5‐yl]prop‐2‐en‐1‐ols.
Authors: Kobayashi Kazuhiro , Suzuki Teruhiko , Imaoka Ayumi , Hiyoshi Hidetaka , Umezu Kazuto 
Published: July 2013

AbstractAn efficient three‐step procedure is elaborated for the synthesis of thiopyrano[2,3‐d]pyrimidines (VI) starting from chloropyrimidine (I).
ChemInform Abstract: Unprecedented Halogenation of Biginelli Compounds of Salicyladehyde.
Authors: Patra Gopal C. , Bhunia Sankar C. , Roy Monoj K. , Pal Sudhir C. 
Published: July 2013

AbstractThe bromination of the non‐bridged (I) or bridged (V) Biginelli compounds of salicylaldehyde is studied.
ChemInform Abstract: Synthesis of Four‐Membered Bissilylene‐Linked Bisamidines.
Authors: Mao Jian‐Wei , Wang Tao , Liu Rui‐Qin , Bai Sheng‐Di , Guo Jian‐Ping , Liu Dian‐Sheng 
Published: July 2013

AbstractTwo four‐membered bissilylene‐linked bisamidines of type (V) are prepared from lithium complexes (I) obtained from primary amines in four steps.
ChemInform Abstract: Palladacycle‐Catalyzed Phosphonation of Aryl Halides in Neat Water.
Authors: Xu Kai , Yang Fan , Zhang Guodong , Wu Yangjie 
Published: July 2013

AbstractCyclopalladated ferrocenylimines are found to be efficient catalysts for the phosphonation of aryl halides with dialkyl phosphonates.
ChemInform Abstract: anti‐HBV Active Constituents from Piper longum
Authors: Jiang Zhi‐Yong , Liu Wen‐Feng , Zhang Xue‐Mei , Luo Jie , Ma Yun‐Bao , Chen Ji‐Jun 
Published: July 2013

Abstractisolation, structure elucidation and anti‐HBV activities of the two new amide alkaloids (I), (II), the two new glycosides longumosides A (III) and B (IV) and seven known compounds
ChemInform Abstract: Antihepatitis B Virus Lignans from the Root of Streblus asper
Authors: Li Jun , Meng Ai‐Ping , Guan Xin‐Lan , Li Jian , Wu Qiang , Deng Sheng‐Ping , Su Xiao‐Jian , Yang Rui‐Yun 
Published: July 2013

Abstractisolation, structural elucidation and anti‐HBV activities of four new lignans, strebluslignanol F (I), erythro‐strebluslignanol G (II), isostrebluslignanaldehyde (III), isomagnaldehyde (IV) along with twelve known lignans
ChemInform Abstract: Reactivity of Cyclohexene Epoxides Toward Intramolecular Acid‐Catalyzed Cyclizations for the Synthesis of Naturally Occurring Cage Architectures
Authors: Abdelkafi Hajer , Evanno Laurent , Deville Alexandre , Dubost Lionel , Nay Bastien 
Published: July 2013

AbstractReview: 31 refs.
6‐Aryl and Heterocycle Quinazoline Derivatives as Potent EGFR Inhibitors with Improved Activity toward Gefitinib‐Sensitive and ‐Resistant Tumor Cell Lines
Authors: Hamed Mostafa M. , Abou El Ella Dalal A. , Keeton Adam B. , Piazza Gary A. , Abadi Ashraf H. , Hartmann Rolf W. , Engel Matthias 
Published: July 2013

AbstractA group of novel anilinoquinazoline derivatives with variable aryl and heterocyclic substituents at position 6 were synthesized and tested for their EGFR‐inhibitory activity. Aryl and heterocyclic rings were attached to the quinazoline scaffold through different linkages such as imine, amide, and thiourea. Most of the aryl and heterocyclic derivatives showed potent inhibition of wild‐type EGFR with IC50 values in the low nanomolar range. Among these, thiourea derivatives 6 a, 6 b and compound 10 b also retained significant activity toward the gefitinib‐insensitive EGFRT790M/L858R mutant, displaying up to 24‐fold greater potency than gefitinib. In addition, cell growth inhibitory activity was tested against cancer cell lines with wild‐type (KB cells) and mutant EGFR (H1975 cells). Several compounds including 6 a were found to be more potent than the reference compound gefitinib toward both cell lines, as was the case for compound 10 b against H1975 cells. Therefore, compounds 6 a and 10 b in particular may serve as new leads for the development of inhibitors effective against wild‐type EGFR as well as gefitinib‐resistant mutants.
Parallel Haskell implementations of the N‐body problem
Authors: Totoo Prabhat , Loidl Hans‐Wolfgang 
Published: July 2013

SUMMARYThis paper provides an assessment of high‐level parallel programming models for multi‐core programming by implementing two versions of the n‐body problem. We compare three different parallel programming models on the basis of parallel Haskell, differing in the ways how potential parallelism is identified and managed. We assess the performance of each implementation, discuss the sequential and parallel tuning steps leading to the final versions and draw general conclusions on the suitability of high‐level parallel programming models for multi‐core programming. We achieve speed‐ups of up to 7.2 for the all‐pairs algorithm and up to 6.5 for the Barnes–Hut algorithm on an 8‐core machine. Copyright © 2013 John Wiley & Sons, Ltd.