bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutrophil extracellular traps promote erectile dysfunction in rats with diabetes mellitus by enhancing NLRP3-mediated pyroptosis
Authors: Xu Ying , Ren Yan , Zou Wenli , Ji Shuiyu , Shen Wei 
Published: July 2024

AbstractErectile dysfunction (ED) is the most prevalent consequences in men with diabetes mellitus (DM). Recent studies demonstrates that neutrophil extracellular traps (NETs) play important roles in DM and its complications. Nevertheless, whether NETs are involved in ED remains unknown. This work intended to explore the role and mechanisms of NETs in ED in the context of DM. Here, we observed that NET generation and pyroptosis were promoted in DM rats with ED compared with controls. Mechanistically, NETs facilitated NLRP3 inflammasome activation and subsequently triggered pyroptosis under high glucose stress, ultimately leading to ED. Intriguingly, DNase I (a NET degrading agent) alleviated ED and corpus cavernosum injury in DM rats. Overall, NETs might induce ED in DM by promoting NLRP3-mediated pyroptosis in the corpus cavernosum.
Survival benefits of propofol-based versus inhalational anesthesia in non-metastatic breast cancer patients: a comprehensive meta-analysis
Authors: Zhang Yingjun , Yu Ping , Bian Lei , Huang Wanwei , Li Na , Ye Feng 
Published: July 2024

AbstractWhether the anesthesia technique, inhalational general anesthesia (IGA) or propofol-based anesthesia (PBA), influences the long-term survival of non-metastatic breast cancer (eBC) remain unclear and controversial. We carried out a literature search on 16thJuly, 2022 for studies comparing IGA and PBA in eBC undergoing standard surgery, according to PRISMA 2020. The major endpoint in our study was overall survival (OS). Seventeen studies including four randomized clinical trials and thirteen retrospective cohort studies were included in the meta-analysis. Ten studies provided data for crude OS in unweighted eBC patients (imbalance in baseline characteristics). The summarized estimate HRs of the PBA group versus the IGA group (ten studies, N = 127,774, IGA group: 92,592, PBA group: 35,182.) was 0.83 (95%CI: 0.78–0.89). Compared with IGA, PBA was associated with both better 1-year OS (two studies, N = 104,083, IGA group: 84,074, PBA group: 20,009. Pooled HR = 0.80, 0.73–0.89) and 5-year OS (six studies, N = 121,580, IGA group: 89,472, PBA group: 32,108. HR = 0.80, 0.74–0.87). Ten studies applied PSM method to balance the baseline characteristics. In these weighted patients, PBA still showed a better OS (ten studies, N = 105,459, IGA group: 79,095, PBA group: 26,364. HR = 0.93, 0.87–1.00), a better 1-year OS (two studies, N = 83,007, IGA group: 67,609, PBA group: 15,398. HR = 0.88, 0.78–0.98) and a trend towards a better 5-year OS (nine studies, N = 121,580, IGA group: 76,797, PBA group: 24,066. HR = 0.95, 0.88–1.03). Loco-regional recurrence-free survival (LRRFS) was also better in PBA group (HR = 0.73, 0.61–0.86). The present study is the first comprehensive meta-analysis to demonstrate that propofol-based anesthesia could significantly improve OS and LRRFS in non-metastatic breast cancer patients, compared with inhalational anesthesia.
Prediction of hematoma expansion in spontaneous intracerebral hemorrhage using a multimodal neural network
Authors: Tanioka Satoru , Aydin Orhun Utku , Hilbert Adam , Ishida Fujimaro , Tsuda Kazuhiko , Araki Tomohiro , Nakatsuka Yoshinari , Yago Tetsushi , Kishimoto Tomoyuki , Ikezawa Munenari , Suzuki Hidenori , Frey Dietmar 
Published: July 2024

AbstractHematoma expansion occasionally occurs in patients with intracerebral hemorrhage (ICH), associating with poor outcome. Multimodal neural networks incorporating convolutional neural network (CNN) analysis of images and neural network analysis of tabular data are known to show promising results in prediction and classification tasks. We aimed to develop a reliable multimodal neural network model that comprehensively analyzes CT images and clinical variables to predict hematoma expansion. We retrospectively enrolled ICH patients at four hospitals between 2017 and 2021, assigning patients from three hospitals to the training and validation dataset and patients from one hospital to the test dataset. Admission CT images and clinical variables were collected. CT findings were evaluated by experts. Three types of models were developed and trained: (1) a CNN model analyzing CT images, (2) a multimodal CNN model analyzing CT images and clinical variables, and (3) a non-CNN model analyzing CT findings and clinical variables with machine learning. The models were evaluated on the test dataset, focusing first on sensitivity and second on area under the receiver operating curve (AUC). Two hundred seventy-three patients (median age, 71 years [59–79]; 159 men) in the training and validation dataset and 106 patients (median age, 70 years [62–82]; 63 men) in the test dataset were included. Sensitivity and AUC of a CNN model were 1.000 (95% confidence interval [CI] 0.768–1.000) and 0.755 (95% CI 0.704–0.807); those of a multimodal CNN model were 1.000 (95% CI 0.768–1.000) and 0.799 (95% CI 0.749–0.849); and those of a non-CNN model were 0.857 (95% CI 0.572–0.982) and 0.733 (95% CI 0.625–0.840). We developed a multimodal neural network model incorporating CNN analysis of CT images and neural network analysis of clinical variables to predict hematoma expansion in ICH. The model was externally validated and showed the best performance of all the models.
Nu–Gr correlation for laminar natural convection heat transfer from a sphere submitted to a constant heat flux surface
Authors: Zhen Qi , Tana  , Sun Yunfeng , Yan Caixia , Wang Hongzhi 
Published: July 2024

AbstractThe work numerically investigated laminar natural convection heat transfer from the single sphere with a constant heat flux surface in air over the wide range of Grashof number ($$10 \le Gr \le 10^{7}$$

10
≤
G
r
≤

10
7

). The more efficient and precise numerical method based on Bejan et al. was employed here, the accuracy of which has been confirmed through validation against a single sphere case. The heat transfer characteristics were systemically analyzed in terms of isothermal contours and streamlines around the sphere, dimensionless temperature and velocity profiles. Additionally, local Nusselt number as well as local pressure and friction drag coefficients were studied with different Grashof number. In comparison to the sphere with uniform heat flux surface, the heat transfer from the isothermal sphere was found to be enhanced attributable to a more robust buoyancy force and a steeper temperature gradient. Moreover, the average Nusselt number for the sphere with a constant heat flux between 60.4 and 98.6% of the isothermal sphere’s value, this range being contingent upon the specific Grashof number. What’s more, the proposed correlation addresses a notable void in the predictive understanding of heat transfer from the sphere with uniform heat flux, which is scenario prevalent in various engineering applications, particularly for the cooling of electrical and nuclear systems, and offer values for academic research.
Pilot study of implementing Managing and Adapting Practice in a German psychotherapy master’s program
Authors: Szota Katharina , van der Meer Anna S. , Bourdeau Teri , Chorpita Bruce F. , Chavanon Mira-Lynn , Christiansen Hanna 
Published: July 2024

AbstractDespite a significant accumulation of research, there has been little systemic implementation of evidence-based practices (EBP) in youth mental health care. The fragmentation of the evidence base complicates implementation efforts. In light of this challenge, we sought to pilot a system that consolidates and coordinates the entire evidence base in a single direct service model (i.e., Managing and Adapting Practice; MAP) in the context of a legal reform of psychotherapy training in Germany. This pilot study aimed to evaluate the feasibility of the implementation of MAP into the curriculum of the reformed German master's program. Eligible participants were students in the master’s program at Philipps-University Marburg during the winter-term 2022/2023. Students first learned about MAP through introductions and role plays (seminar 1), followed by actively planning and conducting interventions using MAP resources for patients in a case seminar under supervision (seminar 2). A repeated-measures survey was conducted to investigate students’ knowledge gains, perception of MAP and changes in their self-rated confidence to use EBP. Results indicated that students perceive MAP to be manageable to learn. Positive progress was achieved with regard to their knowledge and self-reported confidence to use EBP, although interpretation and generalization of the results are limited by small and homogeneous samples, lack of statistical power and missing comparison groups. The feasibility of the implementation and suitability of measures are discussed. Important implications could be drawn with regard to future investigations.
Comprehensive investigation of material properties and operational parameters for enhancing performance and stability of FASnI3-based perovskite solar cells
Authors: Alqurashi Rania Saleh 
Published: July 2024

AbstractRecent advancements in the efficiency of lead-based halide perovskite solar cells (PSCs), exceeding 25%, have raised concerns about their toxicity and suitability for mass commercialization. As a result, tin-based PSCs have emerged as attractive alternatives. Among diverse types of tin-based PSCs, organic–inorganic metal halide materials, particularly FASnI3 stands out for high efficiency, remarkable stability, low-cost, and straightforward solution-based fabrication process. In this work, we modelled the performance of FASnI3 PSCs with four different hole transporting materials (Spiro-OMeTAD, Cu2O, CuI, and CuSCN) using SCAPS-1D program. Compared to the initial structure of Ag/Spiro-OMeTAD/FASnI3/TiO2/FTO, analysis on current–voltage and quantum efficiency characteristics identified Cu2O as an ideal hole transport material. Optimizing device output involved exploring the thickness of the FASnI3 layer, defect density states, light reflection/transmission at the back and front metal contacts, effects of metal work function, and operational temperature. Maximum performance and high stability have been achieved, where an open-circuit voltage of 1.16 V, and a high short-circuit current density of 31.70 mA/cm2 were obtained. Further study on charge carriers capture cross-section demonstrated a PCE of 32.47% and FF of 88.53% at a selected capture cross-section of electrons and holes of 1022 cm2. This work aims to guide researchers for building and manufacturing perovskite solar cells that are more stable with moderate thickness, more effective, and economically feasible.
A single-bridge interleaved three-level LLC resonant converter with current sharing capability for fuel cell system
Authors: Zhao Qianqi , Cheng Xu-Feng , Li Yazhuo , Li He , Wang Dianlong , Liu Chenyang , Zhang Yong 
Published: July 2024

AbstractThis paper propose a wide gain single-bridge interleaved three-level LLC resonant converter with current sharing capability. This novel converter offers numerous advantages, including low cost, low current ripple, reduced voltage and current stress, widely gain range, high efficiency, good current sharing capability and versatile application scalability. Utilizing the three-level inverter + full-wave rectifier LLC converter as a representative case, the paper conducts an in-depth analysis and research on the proposed method. Finality, a 600 W experimental prototype was constructed and tested. Experimental results reveal that the proposed converter exhibits lower current ripple and a broader gain range. Moreover, the converter shows good current sharing capability (with a resonant element tolerance of 10%, the current error between the two phases does not exceed 12%) and high efficiency (peaking at 95.8%).
Experimental study on the effect of PVP, NaCl and EG on the methane hydrates formation and dissociation kinetics
Authors: Shen Kaixiang , Zhao Jin , Zhou Jiawei , Wang Zonghang , Wang Yingsheng 
Published: July 2024

AbstractThe problem of hydrate plug, low efficiency of hydrate dissociation and short production time in hydrate exploitation processes have significantly hindered the commercial viability of gas hydrate extraction. This study investigated the inhibitory effects of ethylene glycol (EG), EG + polyvinyl pyrrolidone (PVP), and EG + PVP + sodium chloride (NaCl) on methane hydrate formation through experiment. The hydrate inhibitory performance is evaluated by using differential of pressure curve, the amount of hydrate, and pressure drop values, and the effects of different temperatures, pressures, inhibitors, and injection time on hydrate dissociation are further studied. The experiment results indicate that the rank of inhibitors combination in terms of effectiveness is 5%EG + 0.5 wt%PVP + 3 wt%Nacl > 10%EG + 1 wt%PVP > 30% EG. At low-temperature conditions, 30% EG exhibits good inhibition of hydrate synthesis but poor dissociation efficiency. As temperature increases, the hydrates dissociation rate with 30% EG also increases. For the combination inhibitor system of EG, PVP, and NaCl, PVP will reduce the dissociation efficiency of hydrates, while EG and Nacl will improve the hydrate dissociation performance. For low production pressure, it is found that 10% EG + 10% NaCl have a good promotion effect on hydrate dissociation, whereas under high production pressure, 20% EG + 10% NaCl is more effective. Furthermore, injecting the inhibitors earlier enhances the dissociation of hydrates more effectively.
Associations between diffusion kurtosis imaging metrics and neurodevelopmental outcomes in neonates with low-grade germinal matrix and intraventricular hemorrhage
Authors: Zhang Chunxiang , Cheng Meiying , Zhu Zitao , Wang Kaiyu , Moon Brianna F. , Shen Sheng , Zhang Bohao , Wang Zihe , Lu Lin , Shang Honglei , Qin Chi , Yang Jinze , Lu Yu , Zhang Xiaoan , Zhao Xin 
Published: July 2024

AbstractDiffusion Kurtosis Imaging (DKI)-derived metrics are recognized as indicators of maturation in neonates with low-grade germinal matrix and intraventricular hemorrhage (GMH-IVH). However, it is not yet known if these factors are associated with neurodevelopmental outcomes. The objective of this study was to acquire DKI-derived metrics in neonates with low-grade GMH-IVH, and to demonstrate their association with later neurodevelopmental outcomes. In this prospective study, neonates with low-grade GMH-IVH and control neonates were recruited, and DKI were performed between January 2020 and March 2021. These neonates underwent the Bayley Scales of Infant Development test at 18 months of age. Mean kurtosis (MK), radial kurtosis (RK) and gray matter values were measured. Spearman correlation analyses were conducted for the measured values and neurodevelopmental outcome scores. Forty controls (18 males, average gestational age (GA) 30 weeks ± 1.3, corrected GA at MRI scan 38 weeks ± 1) and thirty neonates with low-grade GMH-IVH (13 males, average GA 30 weeks ± 1.5, corrected GA at MRI scan 38 weeks ± 1). Neonates with low-grade GMH-IVH exhibited lower MK and RK values in the PLIC and the thalamus (P < 0.05). The MK value in the thalamus was associated with Mental Development Index (MDI) (r = 0.810, 95% CI 0.695–0.13; P < 0.001) and Psychomotor Development Index (PDI) (r = 0.852, 95% CI 0.722–0.912; P < 0.001) scores. RK value in the caudate nucleus significantly and positively correlated with MDI (r = 0.496, 95% CI 0.657–0.933; P < 0.001) and PDI (r = 0.545, 95% CI 0.712–0.942; P < 0.001) scores. The area under the curve (AUC) were used to assess diagnostic performance of MK and RK in thalamus (AUC = 0.866, 0.787) and caudate nucleus (AUC = 0.833, 0.671) for predicting neurodevelopmental outcomes. As quantitative neuroimaging markers, MK in thalamus and RK in caudate nucleus may help predict neurodevelopmental outcomes in neonates with low-grade GMH-IVH.
In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
Authors: Lv Xiaoying , Wang Jia , Yuan Ying , Pan Lurong , Liu Qi , Guo Jinjiang 
Published: July 2024

AbstractDue to considerable global prevalence and high recurrence rate, the pursuit of effective new medication for epilepsy treatment remains an urgent and significant challenge. Drug repurposing emerges as a cost-effective and efficient strategy to combat this disorder. This study leverages the transformer-based deep learning methods coupled with molecular binding affinity calculation to develop a novel in-silico drug repurposing pipeline for epilepsy. The number of candidate inhibitors against 24 target proteins encoded by gain-of-function genes implicated in epileptogenesis ranged from zero to several hundreds. Our pipeline has repurposed the medications with most anti-epileptic drugs and nearly half psychiatric medications, highlighting the effectiveness of our pipeline. Furthermore, Lomitapide, a cholesterol-lowering drug, first emerged as particularly noteworthy, exhibiting high binding affinity for 10 targets and verified by molecular dynamics simulation and mechanism analysis. These findings provided a novel perspective on therapeutic strategies for other central nervous system disease.
Video object detection via space–time feature aggregation and result reuse
Authors: Duan Liang , Yang Rongfei , Yue Kun , Sun Zhengbao , Yuan Guowu 
Published: July 2024

AbstractWhen detecting the objects in videos, motion always leads to object deterioration, like blurring and occlusion, as well as the strange state of the object's shape and posture. Consequently, the detection of video frames will lead to a decline in accuracy by using the image object detection model. This paper proposes an online video object detection method based on the one‐stage detector YOLOx. First, the module for space–time feature aggregation is given, which uses the space–time information of past frames to enhance the feature quality of the current frame. Then, the module for result reuse is given, which incorporates the detection results of past frames to improve the detection stability of the current frame. By these two modules, the trade‐off between accuracy and speed of video object detection could be achieved. Experimental results on the ImageNet VID show the improvement of speed and accuracy of the proposed method.
Design of an electrically small printed square loop antenna for closely spaced Tx/Rx systems
Authors: Truong Nhat , Das Sanghamitro , Sharma Satish K. 
Published: July 2024

AbstractA highly miniaturised electrically small square loop antenna has been designed for operation at 2.5 GHz. The antenna is loaded using a simple series combination of two lumped inductors and two interdigitated capacitors in order to realise inherent impedance matching at a given miniaturisation level with respect to a specified source impedance, without using any external matching network. The designed antenna has an overall size of 0.061λ0 × 0.061λ0, which is approximately 75.6% miniaturised in terms of total loop length and 94% miniaturised in terms of overall footprint. The designed antenna is fabricated and the corresponding impedance matching and radiation patterns are measured, which are found to be in reasonable agreement with their simulated counterparts. Moreover, an investigation with two closely spaced electrically small SLAs, one for transmitting and the other for receiving, is carried out in this work in pursuit of maximising the isolation, which plays a crucial role in the Tx/Rx systems.
Ultraschall- und CTG Kontrollen in der Schwangerschaft: Vorgaben in
den Mutterschafts-Richtlinien und Versorgungswirklichkeit
Authors: Schäfers Rainhild , Wende Danny , Hertle Dagmar 
Published: July 2024

Zusammenfassung
Hintergrund Die Mutterschafts-Richtlinien (MuRiLi) geben die Anzahl von
Ultraschall- und CTG Kontrollen in der Schwangerschaft eindeutig vor. Eine
ältere Studie zeigte ein hohes Maß an Überversorgung.
Methode Mütterbefragung zu den Leistungen in der Schwangerschaft mit
parallel durchgeführter Analyse abgerechneter CTG und
Ultraschalluntersuchungen.
Ergebnisse 223 Frauen mit unauffälliger Schwangerschaft berichteten im
Durchschnitt von 6,2 Ultraschalluntersuchungen. In den Routinedaten wurden
durchschnittlich 2,7 zusätzlich zu den in der Vorsorgepauschale enthaltenen 3
Ultraschalluntersuchungen identifiziert. 216 Befragte mit unauffälliger
Schwangerschaft berichteten im Durchschnitt von 4,8 CTG Kontrollen. In den
Routinedaten fanden sich 5,0.
Fazit Die Vorgaben der MuRiLi werden nicht eingehalten, obwohl bekannt
ist, dass Überversorgung bei unauffälliger Schwangerschaft schaden kann.
A shared-link type wireless power and data simultaneous transfer system based on a series–parallel resonant network
Authors: Liu Ruikang , Ma Hongshuai , Zhang Lei , Li Qian , Pang Junqi , Tan Qiulin 
Published: July 2024

Wireless Power Transmission (WPT) is widely used. In practical engineering applications, the transmitter and receiver of a stable and reliable WPT system need to establish not only a power transmission channel but also a data transmission channel to realize closed-loop control and information interaction. In this paper, a novel simultaneous wireless power and data transfer system based on a series–parallel (SP) resonant network is proposed. The system integrates an SP higher-order resonant network with series carrier injection, which makes power transmission and data transmission share a magnetic coupling channel. The isolation between power and data is realized by exploiting the frequency characteristics of the compensation network, thus realizing efficient power transmission and data transmission. In this paper, accurate and detailed mathematical modeling of the system is conducted, and the gain characteristics of the power transmission channel and the data transmission channel are demonstrated. Meanwhile, the mutual interference between the two channels is analyzed, and a feasible and effective parameter design method is developed. Finally, an experimental prototype with an output power of 16 W and a backward data rate of 100 Kbps is constructed to verify the feasibility of the proposed system and the correctness of the parameter design.
Aspects of morphosyntax of Majorcan Catalan-Spanish bilingual variety
Authors: Guijarro-Fuentes Pedro , Bello Iria , Masià Melania S. 
Published: July 2024

Abstract
This paper studies structural convergence between two Romance languages that are in close contact.
More specifically, it analyzes the differences in clitic realization and object omission in Spanish and Catalan. While
in Spanish it is possible to omit phrases corresponding to direct objects based on their definiteness (Campos, 1986; Clements, 2006) and
not to their syntactic position, Catalan does not regularly omit object pronouns but requires the use of the partitive
en with indefinite antecedents. A five-point Likert scale grammaticality judgment task adapted
from Bruhn de Garavito & Guijarro-Fuentes (2002) was designed to measure
the acceptability of different object expressions in 70 different constructions in Spanish by monolingual native
speakers (n = 44) and Catalan-Spanish bilingual speakers (n = 34). In the task, participants read a short dialogue
containing a question and a short answer and were asked to rate the naturalness of the answer. Linguistic variables
included the type of syntactic structure (simple or complex clauses), the semantic properties of the referent (+/-
definite), and the grammaticality of the utterance. Stimuli were replicated seven times per condition. Results
indicated significant differences between monolinguals and bilinguals, as the latter systematically accept ample
optionality concerning null direct objects. Conversely, differences according to language dominance in the bilingual
group could not be verified. Our data allow us to discuss views on the realization of interpretable features and on
bilingual variability.