bluuebunny/crossref_metadata_2025_split huggingface dataset:
A quantitative study of 3D-scanning frequency and Δd of tracking points on the tooth surface
Authors: Li Hong , Lyu Peijun , Sun Yuchun , Wang Yong , Liang Xiaoyue 
Published: September 2015

AbstractMicro-movement of human jaws in the resting state might influence the accuracy of direct three-dimensional (3D) measurement. Providing a reference for sampling frequency settings of intraoral scanning systems to overcome this influence is important. In this study, we measured micro-movement, or change in distance (∆d), as the change in position of a single tracking point from one sampling time point to another in five human subjects. ∆d of tracking points on incisors at 7 sampling frequencies was judged against the clinical accuracy requirement to select proper sampling frequency settings. The curve equation was then fit quantitatively between ∆d median and the sampling frequency to predict the trend of ∆d with increasing f. The difference of ∆d among the subjects and the difference between upper and lower incisor feature points of the same subject were analyzed by a non-parametric test (α = 0.05). Significant differences of incisor feature points were noted among different subjects and between upper and lower jaws of the same subject (P < 0.01). Overall, ∆d decreased with increasing frequency. When the frequency was 60 Hz, ∆d nearly reached the clinical accuracy requirement. Frequencies higher than 60 Hz did not significantly decrease Δd further.
Designing new strategy for controlling DNA orientation in biosensors
Authors: Feng Chao , Ding Hong-ming , Ren Chun-lai , Ma Yu-qiang 
Published: September 2015

AbstractOrientation controllable DNA biosensors hold great application potentials in recognizing small molecules and detecting DNA hybridization. Though electric field is usually used to control the orientation of DNA molecules, it is also of great importance and significance to seek for other triggered methods to control the DNA orientation. Here, we design a new strategy for controlling DNA orientation in biosensors. The main idea is to copolymerize DNA molecules with responsive polymers that can show swelling/deswelling transitions due to the change of external stimuli and then graft the copolymers onto an uncharged substrate. In order to highlight the responsive characteristic, we take thermo-responsive polymers as an example and reveal multi-responsive behavior and the underlying molecular mechanism of the DNA orientation by combining dissipative particle dynamics simulation and molecular theory. Since swelling/deswelling transitions can be also realized by using other stimuli-responsive (like pH and light) polymers, the present strategy is universal, which can enrich the methods of controlling DNA orientation and may assist with the design of the next generation of biosensors.
Plasmonic mode interferences and Fano resonances in Metal-Insulator- Metal nanostructured interface
Authors: Nicolas Rana , Lévêque Gaëtan , Marae-Djouda Joseph , Montay Guillame , Madi Yazid , Plain Jérôme , Herro Ziad , Kazan Michel , Adam Pierre-Michel , Maurer Thomas 
Published: September 2015

AbstractMetal-insulator-metal systems exhibit a rich underlying physics leading to a high degree of tunability of their spectral properties. We performed a systematic study on a metal-insulator-nanostructured metal system with a thin 6 nm dielectric spacer and showed how the nanoparticle sizes and excitation conditions lead to the tunability and coupling/decoupling of localized and delocalized plasmonic modes. We also experimentally evidenced a tunable Fano resonance in a broad spectral window 600 to 800 nm resulting from the interference of gap modes with white light broad band transmitted waves at the interface playing the role of the continuum. By varying the incident illumination angle shifts in the resonances give the possibility to couple or decouple the localized and delocalized modes and to induce a strong change of the asymmetric Fano profile. All these results were confirmed with a crossed comparison between experimental and theoretical measurements, confirming the nature of different modes. The high degree of control and tunability of this plasmonically rich system paves the way for designing and engineering of similar systems with numerous applications. In particular, sensing measurements were performed and a figure of merit of 3.8 was recorded ranking this sensor among the highest sensitive in this wavelength range.
Fabrication of UV Photodetector on TiO2/Diamond Film
Authors: Liu Zhangcheng , Li Fengnan , Li Shuoye , Hu Chao , Wang Wei , Wang Fei , Lin Fang , Wang Hongxing 
Published: September 2015

AbstractThe properties of ultraviolet (UV) photodetector fabricated on TiO2/diamond film were investigated. Single crystal diamond layer was grown on high-pressure-high-temperature Ib-type diamond substrate by microwave plasma chemical vapor deposition method, upon which TiO2 film was prepared directly using radio frequency magnetron sputtering technique in Ar and O2 mixing atmosphere. Tungsten was used as electrode material to fabricate metal-semiconductor-metal UV photodetector. The dark current is measured to be 1.12 pA at 30 V. The photo response of the device displays an obvious selectivity between UV and visible light and the UV-to-visible rejection ratio can reach 2 orders of magnitude. Compared with that directly on diamond film, photodetector on TiO2/diamond film shows higher responsivity.
Small cell lung cancer transformation and T790M mutation: complimentary roles in acquired resistance to kinase inhibitors in lung cancer
Authors: Suda Kenichi , Murakami Isao , Sakai Kazuko , Mizuuchi Hiroshi , Shimizu Shigeki , Sato Katsuaki , Tomizawa Kenji , Tomida Shuta , Yatabe Yasushi , Nishio Kazuto , Mitsudomi Tetsuya 
Published: September 2015

AbstractLung cancers often harbour a mutation in the epidermal growth factor receptor (EGFR) gene. Because proliferation and survival of lung cancers with EGFR mutation solely depend on aberrant signalling from the mutated EGFR, these tumours often show dramatic responses to EGFR tyrosine kinase inhibitors (TKIs). However, acquiring resistance to these drugs is almost inevitable, thus a better understanding of the underlying resistance mechanisms is critical. Small cell lung cancer (SCLC) transformation is a relatively rare acquired resistance mechanism that has lately attracted considerable attention. In the present study, through an in-depth analysis of multiple EGFR-TKI refractory lesions obtained from an autopsy case, we observed a complementary relationship between SCLC transformation and EGFR T790M secondary mutation (resistance mutation). We also identified analogies and differences in genetic aberration between a TKI-refractory lesion with SCLC transformation and one with EGFR T790M mutation. In particular, target sequencing revealed a TP53 P151S mutation in all pre- and post-treatment lesions. PTEN M264I mutation was identified only in a TKI-refractory lesion with SCLC transformation, while PIK3CA and RB1 mutations were identified only in pre-treatment primary tumour samples. These results provide the groundwork for understanding acquired resistance to EGFR-TKIs via SCLC transformation.
Protein interaction patterns in different cellular environments are revealed by in-cell NMR
Authors: Barbieri Letizia , Luchinat Enrico , Banci Lucia 
Published: September 2015

AbstractIn-cell NMR allows obtaining atomic-level information on biological macromolecules in their physiological environment. Soluble proteins may interact with the cellular environment in different ways: either specifically, with their functional partners, or non-specifically, with other cellular components. Such behaviour often causes the disappearance of the NMR signals. Here we show that by introducing mutations on the human protein profilin 1, used here as a test case, the in-cell NMR signals can be recovered. In human cells both specific and non-specific interactions are present, while in bacterial cells only the effect of non-specific interactions is observed. By comparing the NMR signal recovery pattern in human and bacterial cells, the relative contribution of each type of interaction can be assessed. This strategy allows detecting solution in-cell NMR spectra of soluble proteins without altering their fold, thus extending the applicability of in-cell NMR to a wider range of proteins.
The effects of Bombyx mori silk strain and extraction time on the molecular and biological characteristics of sericin
Authors: Siritientong Tippawan , Bonani Walter , Motta Antonella , Migliaresi Claudio , Aramwit Pornanong 
Published: September 2015

Abstract
Sericin was extracted from three strains of Thai Bombyx mori silk cocoons (white shell Chul1/1, greenish shell Chul3/2, and yellow shell Chul4/2) by a high-pressure and high-temperature technique. The characteristics of sericin extracted from different fractions (15, 45, and 60 min extraction process) were compared. No differences in amino acid composition were observed among the three fractions. For all silk strains, sericin extracted from a 15-min process presented the highest molecular weight. The biological potential of the different sericin samples as a bioadditive for 3T3 fibroblast cells was assessed. When comparing sericin extracted from three silk strains, sericin fractions extracted from Chul4/2 improved cell proliferation, while sericin from Chul 1/1 activated Type I collagen production to the highest extent. This study allows the natural variability of sericin obtained from different sources and extraction conditions to be addressed and provides clues for the selection of sericin sources.
On finding solutions of a Kirchhoff type problem
Authors: Huang Yisheng , Liu Zeng , Wu Yuanze 
Published: September 2015

Consider the Kirchhoff type problem

{

−

(

a
+
b

∫

B

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|

∇
u

|

2

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)

Δ
u

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;

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m
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;

in

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on

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\begin{equation}\tag {$\mathcal {P}$} \left \{ \begin {aligned} -\bigg (a+b\int _{\mathbb {B}_R}|\nabla u|^2dx\bigg )\Delta u&= \lambda u^{q-1} + \mu u^{p-1}, &&\text {in $\mathbb {B}_R$}, \\ u&>0, &&\text {in $\mathbb {B}_R$},\\ u&=0, &&\text {on $\partial \mathbb {B}_R$}, \end{aligned} \right . \end{equation}

where

B

R

⊂

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N

(
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≥
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)

\mathbb {B}_R\subset \mathbb {R}^N(N\geq 3)

is a ball,

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≤

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:=

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2\leq q>p\leq 2^*:=\frac {2N}{N-2}

and

a
a

,

b
b

,

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\lambda

,

μ
\mu

are positive parameters. By introducing some new ideas and using the well-known results of the problem

(

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)

(\mathcal {P})

in the cases of

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=
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=
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a=\mu =1

and

b
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0

b=0

, we obtain some special kinds of solutions to

(

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for all

N
≥
3

N\geq 3

with precise expressions on the parameters

a
a

,

b
b

,

λ
\lambda

,

μ
\mu

, which reveals some new phenomenons of the solutions to the problem

(

P

)

(\mathcal {P})

. It is also worth pointing out that it seems to be the first time that the solutions of

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can be expressed precisely on the parameters

a
a

,

b
b

,

λ
\lambda

,

μ
\mu

, and our results in dimension four also give a partial answer to Naimen’s open problems [J. Differential Equations 257 (2014), 1168–1193]. Furthermore, our results in dimension four seem to be almost “optimal”.
Shakespeare in London
Authors: Wells Stanley 
Published: September 2015

Abstract
‘Shakespeare in London’ describes Shakespeare’s professional life in London and what is known about his private life at that time. It considers how he worked and where his plays came from. Shakespeare borrowed the narrative material of almost all his plays from books, whether fictional, mythical, historical, or theatrical, but he turned this raw material into original drama. It also describes his poems that seem to be composed for his own pleasure; a collection of 154 of these sonnets were published in 1609 by Thomas Thorpe. Shakespeare’s writing career seems to have come to an end around the time that the Globe burnt down, in June 1613, but was this just a coincidence?
Plays of the 1590s
Authors: Wells Stanley 
Published: September 2015

Abstract
During the first decade of Shakespeare’s career he wrote a series of closely inter-related plays based on English history drawing heavily on Holinshed’s Chronicles and other accounts. These plays show a serious concern with political problems, with the responsibilities of a king, his relationship with the people, the need for national unity, and the relationship between national welfare and self-interest. ‘Plays of the 1590s’ introduces each of these plays, sketching its origins, stories, and themes. It also touches on aspects of Shakespeare’s techniques and artistry. The plays considered are Henry VI (Parts One to Three), Richard III, Titus Andronicus, Romeo and Juliet, Richard II, Henry IV, Henry V , Edward III, and King John.
Tragicomedy
Authors: Wells Stanley 
Published: September 2015

Abstract
Shakespeare’s restlessly imaginative exploration of the possibilities of comic form led him into new paths in four plays based on romance literature that show him continuing to experiment with new dramatic techniques. All their plots include highly improbable and supernatural elements. All tell of high-born families and lovers separated by catastrophe, sometimes natural, at other times humanly contrived. All span large areas of space and time and involve leading characters in suffering. Tragicomedy describes Pericles, Cymbeline, The Winter’s Tale, and The Tempest before going on to discuss Shakespeare’s collaboration with John Fletcher at the very end of his career when they worked together on Cardenio, All Is True, and The Two Noble Kinsmen.
Epilogue
Authors: Wells Stanley 
Published: September 2015

Abstract
Shakespeare’s plays and poems have had, and continue increasingly to have, a major impact on many areas of human life. Fellow poets from Ben Jonson onwards have written appreciatively of Shakespeare and have been inspired by him. Over the years, philosophers and thinkers of many nationalities have come under Shakespeare’s influence and written about him. The ‘Epilogue’ explains that Shakespeare can be appreciated and enjoyed in many different ways. The most obvious way to get to know him is to see his plays performed in the medium for which he wrote them, the theatre. To do so is to experience simultaneously the art of the playwright and the art of his interpreters.
Genetic landscape with sharp discontinuities shaped by complex demographic history in moose ( Alces alces )
Authors: Wennerström Lovisa , Ryman Nils , Tison Jean-Luc , Hasslow Anna , Dalén Love , Laikre Linda 
Published: September 2015

AbstractThe moose ( Alces alces ) is the most intensely managed game species in Fennoscandia; approximately one-third of the population, ca. 160,000 animals, is harvested annually. Despite the species’ biological and socioeconomic importance, there are knowledge gaps with respect to its intraspecific diversity and genetic structure. Recent studies of moose in neighboring countries report 2 genetic groups in Finland, 3 in Norway with one of them suggested to be of ancient origin, and no indications of bottlenecks. To delineate the spatial genetic landscape of the Swedish moose, we used allozyme variability from over 20,000 georeferenced moose collected all over Sweden in combination with 12 microsatellites ( n &gt; 1,200) and mitochondrial DNA (mtDNA) sequences ( n = 44). We combined individual-based and traditional statistical approaches with coalescence-based simulations. The results indicate a complex history with bottlenecks and recent expansions that is consistent with historical records. Swedish moose are separated into 2 major genetic groups, a northern and a southern one, where the southern group is further divided into 3 subgroups. The 2 main subpopulations are moderately differentiated ( FST = 0.1; RST = 0.07) and separated by sharp genetic discontinuities occurring over a relatively narrow transition zone in central Sweden that coincides with a similar, previously reported transition zone in Norway. This differentiation is not reflected in mtDNA variation, where no significant divergence was observed. Together with the FST and RST similarities, this suggests that the 2 major subpopulations in Sweden reflect divergence shaped after the postglacial recolonization of Scandinavia. Neighborhood size assessments indicate that gene flow is relatively restricted with an estimated average dispersal distance of 3.5–11.1 km, and spatial autocorrelograms suggest that genetic similarity decreases almost linearly over space resulting in continuous genetic clines within major subgroups. Management areas largely coincide with genetic clusters, simplifying the integration of genetic information into management.
ALMA images of discs: are all gaps carved by planets?
Authors: Gonzalez J.-F. , Laibe G. , Maddison S. T. , Pinte C. , Ménard F. 
Published: September 2015

Abstract
Protoplanetary discs are now routinely observed and exoplanets, after the numerous indirect discoveries, are starting to be directly imaged. To better understand the planet formation process, the next step is the detection of forming planets or of signposts of young planets still in their disc, such as gaps. A spectacular example is the Atacama Large Millimeter/submillimeter Array (ALMA) science verification image of HL Tau showing numerous gaps and rings in its disc. To study the observability of planet gaps, we ran 3D hydrodynamical simulations of a gas and dust disc containing a 5 MJ gap-opening planet and characterized the spatial distribution of migrating, growing and fragmenting dust grains. We then computed the corresponding synthetic images for ALMA. For a value of the dust fragmentation threshold of 15 m s−1 for the collisional velocity, we identify for the first time a self-induced dust pile-up in simulations taking fragmentation into account. This feature, in addition to the easily detected planet gap, causes a second apparent gap that could be mistaken for the signature of a second planet. It is therefore essential to be cautious in the interpretation of gap detections.
OP‐12 PREVALENCE OF FUNCTIONAL CONSTIPATION IN INFANTS AND TODDLERS IN SRI LANKA
Authors: Walter Hannah A.W. , Hovenkamp Anne , Rajindrajith Shaman , Devanarayana Niranga M. , Rajapakshe Nimna N. , Benninga Marc A. 
Published: September 2015

Objective:To determine the prevalence of functional constipation (FC) in toddlers in Sri Lanka and to identify risk factors associated with the development of FC, such as demographic features, social and economic factors.Methods:Children between 7 months and 5 years of age were selected from 14 well baby and vaccination clinics in the Gampaha District, Sri Lanka. Data were collected using a self‐administered questionnaire. The questionnaire contained questions regarding the child's bowel habits, socio‐demographic characteristics as well as physical and verbal violence against mother and/or child. Functional constipation was diagnosed according to ROMEIII criteria.Results:A total of 1151 toddlers were included in the analysis, (female n = 588 [50,8%], mean age 21,7 months, standard deviation [SD] 12,5 months). A total of, 92 children (8,0%) fulfilled the Rome III criteria for FC. The prevalence of constipation was significantly and independently associated with first birth order (9,6% vs. 6,5% p = 0,026), underweight [<2SD] (15,0% vs. 7,1%, p = 0,004) and living in an urban residence (9,5% vs. 5,8%, p = 0,023). Odds ratios [OR] and 95% confidence intervals [CI] are were respectively 1,61 (CI; 1,02–2,53), 2,53 (CI; 1,45–4,41), 1,70 (CI; 1,08–2,69). Toddlers being overweight, being subject to violence or with mothers subject to violence illustrated higher prevalence of FC, but p‐values were >0,05. No association was found with gender, age, parental age, parental education level, shortage in income and quality of relationship between parents.Conclusions:Functional constipation is a significant health problem in toddlers in Sri Lanka, concerning 8 percent of its population between 7 months and 5 years old. Toddlers being first born, underweight and living in an urban area show a significant higher risk for FC.
PP‐6 BOLUS CLEARANCE TIME IS ASSOCIATED WITH REFLUX SEVERITY AND IT IS INVERSELY CORRELATED TO BASELINE IMPEDANCE VALUES IN ADOLESCENTS WITH GASTROESOPHAGEAL REFLUX DISEASE
Authors: Tolone Salvatore , de Bortoli Nicola , Savarino Edoardo , Strisciuglio Caterina , Tolone Carlo 
Published: September 2015

Aims:The role of esophageal clearance is still scarcely investigated in patients with gastroesophageal reflux disease (GERD). We aimed to assess esophageal clearance in adolescents by means of bolus clearance time (BCT) and to verify if there is any difference among subgroups of GERD patients according to endoscopic and impedance‐pH monitoring findings.Methods:We revised endoscopic and impedance‐pH monitoring (off‐therapy) data of 28 consecutive adolescents (range 12–16 years). We evaluated acid exposure time (AET), total number of reflux episodes, baseline impedance (BI), and BCT. According to impedance‐pH monitoring features, adolescents were grouped into pH/MII negative (normal AET and normal number of refluxes), and pH/MII positive (abnormal AET and/or abnormal number of refluxes). This latter were further subgrouped on the basis of abnormal/normal AET (pH+/‐) and abnormal/normal number of refluxes (MII+/‐). Finally, adolescents were also classified as erosive and non erosive reflux disease (ERD, NERD).Results:We observed 22 pH/MII positive adolescents (7 ERD and 15 NERD). Eight patients were further subgrouped as pH+/MII‐, 6 as pH‐/MII+ and 8 as pH+/MII+. BCT values (in seconds) progressively decreased from pH+/MII+, pH+/MII‐, pH‐/MII+ to pH‐/MII‐ (34.5 ± 8.1 vs. 22.0 ± 7.2 vs. 16.4 ± 4.5 vs. 10.1 ± 2.1, respectively; p < 0.001), whereas BI gradually increased (1236 ± 358 vs. 1592 ± 762 vs. 1854 ± 567 vs. 3256 ± 743, respectively; p < 0.001). There was an inverse correlation between BCT and BI, and a direct correlation between BCT and AET (p < 0.0001) and ERD presence (p < 0.0001).Conclusions:BCT seems to reflects reflux severity, and it is inversely correlated to BI, a marker of mucosal integrity, supporting the role of esophageal clearance in the GERD pathophysiology.