bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase transition in polymer hydrogels investigated by swelling, DSC, FTIR and NMR
Authors: Krakovský Ivan , Hanyková Lenka , Štastná Julie 
Published: July 2024

AbstractThe swelling and thermal behavior of single (SN) and double network (DN) hydrogels containing polyacrylamide (PAAm) and temperature sensitive poly(N, N-diethylacrylamide) (PNNDEAAm) were investigated by gravimetry and differential scanning calorimetry (DSC). Changes of the hydration of carbonyl groups and mobility of polymer network chains in the hydrogels with temperature were studied by Fourier-transformed infrared and proton nuclear magnetic resonance (1H NMR) spectroscopy. The enthalpy of dissociation of the hydrophobic interaction, minimum and maximum numbers of water molecules per monomer unit in PNNDEAAm SN hydrogel involved in the hydrophobic hydration were determined by DSC. The volume phase transition accompanied by expulsion/uptake of water and heat absorption/release in heating/cooling was exhibited by all DN hydrogels containing PNNDEAAm. In these hydrogels, above the phase transition temperature, the population of hydrated carbonyls is enriched with the free and single hydrated ones in the same way as in the aqueous solution of linear PNNDEAAm and mobility of the PNNDEAAm chains is strongly reduced. Presence of the PAAm network does not influence the phase transition temperature but strongly reduces the enthalpy of the phase transition, promotes higher degrees of hydration of carbonyls, and increases mobility of the PNNDEAAm chains in the mixed hydrogels above the phase transition temperature.
Isolation and characterisation of two epithelial-like cell lines from the gills of Chrysophrys auratus (Australasian snapper) and Oncorhynchus tshawytscha (Chinook salmon) and their use in aquatic toxicology
Authors: Böhmert Björn , Chong Gavril L. W. , Lo Kim , Algie Michael , Colbert Damon , Jordan Melissa D. , Stuart Gabriella , Wise Lyn M. , Lee Lucy E. J. , Bols Niels C. , Dowd Georgina C. 
Published: July 2024

AbstractIn vitro gill models are becoming increasingly important in aquatic toxicology, yet the fish gill invitrome is underrepresented, encompassing approximately 0.1% of extant species. Here, we describe the establishment and characterisation of two gill-derived, epithelial-like cell lines isolated from fish species of significant importance to New Zealand: Chrysophrys auratus (Australasian snapper) and Oncorhynchus tshawytscha (Chinook salmon). Designated CAgill1PFR (Chrysophrys auratus,gill 1, Plant & Food Research) and OTgill1PFR (Oncorhynchus tshawytscha,gill 1, Plant & Food Research), these cell lines have each been passaged greater than each 70 times over several years and are considered spontaneously immortalised. Both cell lines required serum for growth and exhibited differential responses to basal media formulations. CAgill1PFR was sensitive to low temperatures (4 °C) but replicated at high temperatures (30 °C), whereas OTgill1PFR was sensitive to high temperatures but remained viable at low temperatures, mirroring the natural environment of their host species. Immunostaining revealed expression of epithelial cell markers cytokeratin and E-cadherin, alongside positivity for the mesenchymal cell marker, vimentin. CAgill1PFR was more sensitive to the environmental toxin 3,4 dichloroaniline than OTgill1PFR through measurements of metabolic activity, membrane integrity, and lysosomal function. Furthermore, CAgill1PFR produced less CYP1A activity, indicative of ongoing biotransformation processes, in response to beta-naphthoflavone than OTgill1PFR. These cell lines expand the toolbox of resources and emphasise the need for species-specific aquatic toxicology research.
Ultrasound Urodynamics: A Review of Ultrasound Imaging Techniques for Enhanced Bladder Functional Diagnostics
Authors: McCormack Brendan , Hampton Hailey L. , Speich John E. , Radley Stephen C. , Burkett Linda S. , Klausner Adam P. 
Published: July 2024

Abstract
Purpose of Review
Invasive urodynamics are currently used to diagnose disorders of bladder function. However, due to patient discomfort as well as artifacts induced by catheters and non-physiologic filling, less invasive screening tools that can improve diagnostic information, such as ultrasound are required. The purpose of this review is to assess different modalities of ultrasound as applied to functional bladder imaging. This information will help guide future studies in the use of ultrasound during urodynamics.

Recent Findings
Recently, multiple studies have employed ultrasound to evaluate bladder volume, wall thickness, shape, vibrometry, elastography, compliance, biomechanics, and micromotion during urodynamics. These new techniques have used both 2D and 3D ultrasound techniques to evaluate bladder changes during filling. Continued research is needed to confirm ongoing findings prior to widespread incorporation into clinical practice.

Summary
This review demonstrates the potential use of ultrasound as an adjunct to urodynamics for the diagnostic evaluation of functional bladder disorders.
Evidence-based Prostate Cancer Screening Interventions for Black Men: A Systematic Review
Authors: Lopez Abigail , Bailey Jared T. , Galloway Dorothy , Woods-Burnham Leanne , Montgomery Susanne B. , Kittles Rick , Teteh-Brooks Dede K. 
Published: July 2024

Abstract
Prostate cancer is the second leading cause of death for men in the U.S. and Black men are twice as likely to die from the disease. However, prostate cancer, if diagnosed at an earlier stage, is curable. The purpose of this review is to identify prostate cancer screening clinical trials that evaluate screening decision-making processes of Black men.

Methods
The databases PubMed, Ovid MEDLINE, CINAHL Plus, and PsychInfo were utilized to examine peer-reviewed publications between 2017 and 2023. Data extracted included implementation plans, outcome measures, intervention details, and results of the study. The Critical Appraisal Skills Programme was used to assess the quality of the evidence presented.

Results
Of the 206 full-text articles assessed, three were included in this review. Educational interventions about prostate cancer knowledge with shared and informed decision-making (IDM) features, as well as counseling, treatment options, and healthcare navigation information, may increase prostate cancer screening participation among Black men. Additionally, health partner educational interventions may not improve IDM related to screening participation. The quality of the evidence presented in each article was valid and potentially impactful to the community.

Discussion
Black men face various social determinants of health barriers related to racism, discrimination, cost of health services, time away from work, and lack of trust in the healthcare system when making health-related decisions, including prostate cancer screening participation. A multifactorial intervention approach is required to address these inequities faced by Black men especially as prostate cancer is curable when diagnosed at an earlier stage.
Sustainable development goal 12 and its synergies with other SDGs: identification of key research contributions and policy insights
Authors: Raman Raghu , Lathabai Hiran H. , Nedungadi Prema 
Published: July 2024

AbstractThe relationships of SDG 12 (responsible consumption and production) with other sustainable development goals (SDGs), both direct and indirect, necessitate a systematic analysis to understand its pivotal role in achieving other SDGs. This work focuses on a threefold investigation through a scientometric framework. Initially, the study sought to map and analyze the naturally formed linkages between SDG 12 and other SDGs by examining the literature specifically devoted to SDG 12, thereby revealing the SDGs that are strongly linked to SDG 12. The subsequent phase of the investigation identified prominent topics related to SDG 12 that require detailed exploration. Finally, the selected topics are mined through a methodical approach termed flow vergence gradient analysis, allowing for the revelation of significant contributions within each topic. Through the analysis of the SDG linkage map, SDG 13 (climate action), SDG 7 (affordable and clean energy), SDG 11 (sustainable cities and communities), and SDG 15 (life on land), among others, were recognized as closely linked to SDG 12. Following this identification, five major topics—Industrial Symbiosis, Electronic waste, Carbon emissions, Life Cycle Assessment, and Green products—were deemed suitable for comprehensive mining to extract pivotal contributions. As policy recommendations, adopting a multifaceted approach to e-waste management and sustainable practices is imperative. Implementing consumption-based accounting (CBA) to achieve SDG 12 holistically will be useful. Businesses must align with circular economy principles, minimize hazardous materials, and adhere to low-emission, green supply chain practices. The emphasis is also on the need for proactive R&D collaboration with academia to meet SDG 12 targets, alongside engaging in community awareness through corporate social responsibility initiatives.
Inter‐Regional Food‐Water‐Income Synergy Through Bi‐Level Crop Redistribution Model Coupled With Virtual Water: A Case Study of China’s Hetao Irrigation District
Authors: Yin Jieling , Li Xin , Engel Bernie A. , Ding Jiayi , Xing Xin , Sun Shikun , Wang Yubao 
Published: July 2024

AbstractIncorporating water footprints and virtual water into crop redistribution provides a new approach for efficient water resources utilization and synergistic development of water surplus and scarce regions. In this work, the absolute and comparative advantage of the production‐based blue and gray water footprint (PWFblue and PWFgray), the calorie‐based blue water footprint (CWFblue) and the net benefit‐based blue water footprint (NBWFblue) were used as coefficients to establish a bi‐level crop redistribution model. The mode considers upper‐level decision makers interested in maximizing food security and ecological security and lower‐level decision makers interested in water use efficiency, water use benefits and net benefits. The model was applied in the Hetao Irrigation District (HID), China. The results showed that after optimization, the PWFblue, CWFblue, NBWFblue, and gray water footprint (GWF) of the HID were reduced by 23.32%, 5.60%, 17.40%, and 6.67%, respectively. National benefits were improved, especially when considering synergistic optimization, although the net benefits of HID was affected. The calorie supply increased by 9.6 × 109 kcal, the GWF decreased by 8.29 × 106 m3, and water use efficiency and benefits were improved in China. In contrast, the calorie supply and the net benefits of the HID decreased, while the GWF increased. Moreover, multiple stakeholders were involved in crop redistribution and required national synergies. The bi‐level model proved more suitable than the multi‐objective model. The model proposed in this work considers synergies outside the region in crop redistribution within the region, and can provide new insight for water and soil resources management in arid and semi‐arid regions.
Evaluating the Seasonal Responses of Southern Ocean Sea Surface Temperature to Southern Annular Mode in CMIP6 Models
Authors: Hu Yihang , Tian Wenshou , Dong Yuxin , Zhang Jiankai 
Published: July 2024

AbstractUsing observations and CMIP6 historical simulations, the seasonal responses of Southern Ocean (50°S–70°S) sea surface temperature (SST) to Southern Annular Mode (SAM) variations are investigated in this study. The results suggest that the averaged Southern Ocean SST in austral spring and summer show a significant cooling in response to a positive SAM, while the responses in austral autumn and winter are negligible. The cooling effect is resulted from the cold water in higher latitudes and deeper oceans brought by the equatorward Ekman transport and the Ekman pumping associated with the positive SAM. Among CMIP6 models, the magnitude of the simulated cooling response connects to the climatological meridional and vertical ocean temperature gradients, and the magnitude of Ekman motion in response to SAM. In addition, the spring and summer SAM plays a more important role in modulating Southern Ocean SST in autumn and winter than the autumn and winter SAM.
Vegetation‐Generated Turbulence Does Not Impact the Erosion of Natural Cohesive Sediment
Authors: Deitrick Autumn R. , Ralston David K. , Esposito Christopher R. , Baustian Melissa M. , Burgos Maricel Beltrán , Courtois Andrew J. , Nepf Heidi 
Published: July 2024

AbstractPrevious studies have demonstrated that vegetation‐generated turbulence can enhance erosion rate and reduce the velocity threshold for erosion of non‐cohesive sediment. This study considered whether vegetation‐generated turbulence had a similar influence on natural cohesive sediment. Cores were collected from a black mangrove forest with aboveground biomass and exposed to stepwise increases in velocity. Erosion was recorded through suspended sediment concentration. For the same velocity, cores with pneumatophores had elevated turbulent kinetic energy compared to bare cores without pneumatophores. However, the vegetation‐generated turbulence did not increase bed stress or the rate of resuspension, relative to bare cores. It was hypothesized that the short time‐scale fluctuations associated with vegetation‐generated turbulence were not of sufficient duration to break cohesion between grains, explaining why elevated levels of turbulence associated with the pneumatophores had no impact on the erosion threshold or rate.
Deep Learning‐Based Prediction of Global Ionospheric TEC During Storm Periods: Mixed CNN‐BiLSTM Method
Authors: Ren Xiaochen , Zhao Biqiang , Ren Zhipeng , Wang Yan , Xiong Bo 
Published: July 2024

AbstractThe application of deep learning in high‐precision ionospheric parameter prediction has become one of the focus in space weather research. In this study, an improved model called Mixed Convolutional Neural Networks (CNN)—Bi‐Long Short Term Memory is proposed for predicting future ionospheric Total Electron Content (TEC). The model is trained using the longest available (25 years) Global Ionospheric Maps‐TEC and evaluated the accuracy of ionospheric storm predictions. The results indicate that using historical TEC in the solar‐geographical reference frame as input driving data achieves higher prediction accuracy compared to that in the geocentric coordinate system. Additionally, by comparing different input parameters, it is found that incorporating the Kp, ap, and Dst indices as inputs to the model effectively improves its accuracy, especially in long‐term forecasting where R2 increased by 3.49% and Root Mean Square Error decreased by 13.48%. Compared with BiLSTM‐Deep Neural Networks (DNN) and CNN‐BiLSTM, the Mixed CNN‐BiLSTM model has the highest prediction accuracy. It suggests that the utilization of CNN modules for processing spatial information, along with the incorporation of DNN modules to incorporate geomagnetic indices for result correction. Moreover, in short‐term predictions, the model accurately forecasts the evolution process of ionospheric storms. When extending the predicted length, although there are cases of prediction errors, the model still captures the entire process of ionospheric storms. Furthermore, the predicted results are significantly influenced by longitude, magnetic latitude, and local time.
Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Authors: Hu Lifang , Chen Wei , Qian Airong , Li Yi-Ping 
Published: July 2024

AbstractWnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and adult life. Aberrant Wnt signaling pathway underlies a wide range of human disease pathogeneses. In this review, we provide an update of Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and diseases. The Wnt proteins, receptors, activators, inhibitors, and the crosstalk of Wnt signaling pathways with other signaling pathways are summarized and discussed. We mainly review Wnt signaling functions in bone formation, homeostasis, and related diseases, and summarize mouse models carrying genetic modifications of Wnt signaling components. Moreover, the therapeutic strategies for treating bone diseases by targeting Wnt signaling, including the extracellular molecules, cytosol components, and nuclear components of Wnt signaling are reviewed. In summary, this paper reviews our current understanding of the mechanisms by which Wnt signaling regulates bone formation, homeostasis, and the efforts targeting Wnt signaling for treating bone diseases. Finally, the paper evaluates the important questions in Wnt signaling to be further explored based on the progress of new biological analytical technologies.
Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells
Authors: Sousa Alexander A. , Hemez Colin , Lei Lei , Traore Soumba , Kulhankova Katarina , Newby Gregory A. , Doman Jordan L. , Oye Keyede , Pandey Smriti , Karp Philip H. , McCray Paul B. , Liu David R. 
Published: July 2024

Abstract
Prime editing (PE) enables precise and versatile genome editing without requiring double-stranded DNA breaks. Here we describe the systematic optimization of PE systems to efficiently correct human cystic fibrosis (CF) transmembrane conductance regulator (CFTR) F508del, a three-nucleotide deletion that is the predominant cause of CF. By combining six efficiency optimizations for PE—engineered PE guide RNAs, the PEmax architecture, the transient expression of a dominant-negative mismatch repair protein, strategic silent edits, PE6 variants and proximal ‘dead’ single-guide RNAs—we increased correction efficiencies for CFTR F508del from less than 0.5% in HEK293T cells to 58% in immortalized bronchial epithelial cells (a 140-fold improvement) and to 25% in patient-derived airway epithelial cells. The optimizations also resulted in minimal off-target editing, in edit-to-indel ratios 3.5-fold greater than those achieved by nuclease-mediated homology-directed repair, and in the functional restoration of CFTR ion channels to over 50% of wild-type levels (similar to those achieved via combination treatment with elexacaftor, tezacaftor and ivacaftor) in primary airway cells. Our findings support the feasibility of a durable one-time treatment for CF.
CALiSol-23: Experimental electrolyte conductivity data for various Li-salts and solvent combinations
Authors: de Blasio Paolo , Elsborg Jonas , Vegge Tejs , Flores Eibar , Bhowmik Arghya 
Published: July 2024

AbstractIon transport in non-aqueous electrolytes is crucial for high performance lithium-ion battery (LIB) development. The design of superior electrolytes requires extensive experimentation across the compositional space. To support data driven accelerated electrolyte discovery efforts, we curated and analyzed a large dataset covering a wide range of experimentally recorded ionic conductivities for various combinations of lithium salts, solvents, concentrations, and temperatures. The dataset is named as ’Conductivity Atlas for Lithium salts and Solvents’ (CALiSol-23). Comprehensive datasets are lacking but are critical to building chemistry agnostic machine learning models for conductivity as well as data driven electrolyte optimization tasks. CALiSol-23 was derived from an exhaustive review of literature concerning experimental non-aqueous electrolyte conductivity measurement. The final dataset consists of 13,825 individual data points from 27 different experimental articles, in total covering 38 solvents, a broad temperature range, and 14 lithium salts. CALiSol-23 can help expedite machine learning model development that can help in understanding the complexities of ion transport and streamlining the optimization of non-aqueous electrolyte mixtures.
Boundaries of task-specificity: bimanual finger dexterity is reduced in musician’s dystonia
Authors: Sadnicka Anna , Wiestler Tobias , Butler Katherine , Altenmuller Eckart , Edwards Mark J. , Ejaz Naveed , Diedrichsen Jörn 
Published: July 2024

AbstractTask-specific dystonia leads to loss of sensorimotor control for a particular motor skill. Although focal in nature, it is hugely disabling and can terminate professional careers in musicians. Biomarkers for underlying mechanism and severity are much needed. In this study, we designed a keyboard device that measured the forces generated at all fingertips during individual finger presses. By reliably quantifying overflow to other fingers in the instructed (enslaving) and contralateral hand (mirroring) we explored whether this task could differentiate between musicians with and without dystonia. 20 right-handed professional musicians (11 with dystonia) generated isometric flexion forces with the instructed finger to match 25%, 50% or 75% of maximal voluntary contraction for that finger. Enslaving was estimated as a linear slope of the forces applied across all instructed/uninstructed finger combinations. Musicians with dystonia had a small but robust loss of finger dexterity. There was increased enslaving and mirroring, primarily during use of the symptomatic hand (enslaving p = 0.003; mirroring p = 0.016), and to a lesser extent with the asymptomatic hand (enslaving p = 0.052; mirroring p = 0.062). Increased enslaving and mirroring were seen across all combinations of finger pairs. In addition, enslaving was exaggerated across symptomatic fingers when more than one finger was clinically affected. Task-specific dystonia therefore appears to express along a gradient, most severe in the affected skill with subtle and general motor control dysfunction in the background. Recognition of this provides a more nuanced understanding of the sensorimotor control deficits at play and can inform therapeutic options for this highly disabling disorder.
Origin of asteroid (101955) Bennu and its connection to the New Polana family
Authors: Takir Driss , Emery Joshua P. , Bottke William F. , Arredondo Anicia 
Published: July 2024

AbstractThe asteroid (142) Polana is classified as a B-type asteroid located in the inner Main Belt. This asteroid is the parent of the New Polana family, which has been proposed to be the likely source of primitive near-Earth asteroids such as the B-type asteroid (101955) Bennu. To investigate the compositional correlation between Polana and Bennu at the 3 µm band and their aqueous alteration histories, we analyzed the spectra of Polana in the ~ 2.0–4.0 µm spectral range using the NASA Infrared Telescope Facility in Hawai’i. Our findings indicate that Polana does not exhibit discernable 3 µm hydrated mineral absorption (within 2σ), which is in contrast to asteroid Bennu. Bennu displayed a significant 3 µm absorption feature similar to CM- and CI-type carbonaceous chondrites. This suggests two possibilities: either Bennu did not originate from the New Polana family parented by asteroid Polana or the interior of Bennu’s parent body was not homogenous, with diverse levels of aqueous alteration. Several explanations support the latter possibility, including heating due to shock waves and pressure, which could have caused the current dehydrated state of Bennu’s parent body.