bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility
Authors: Ignatiadis Michail , Lee Mark , Jeffrey Stefanie S. 
Published: November 2015

Abstract
Recent technological advances have enabled the detection and detailed characterization of circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) in blood samples from patients with cancer. Often referred to as a “liquid biopsy,” CTCs and ctDNA are expected to provide real-time monitoring of tumor evolution and therapeutic efficacy, with the potential for improved cancer diagnosis and treatment. In this review, we focus on these opportunities as well as the challenges that should be addressed so that these tools may eventually be implemented into routine clinical care. Clin Cancer Res; 21(21); 4786–800. ©2015 AACR.
Filtering the Stochastic Skeleton Model for the Madden–Julian Oscillation
Authors: Chen Nan , Majda Andrew J. 
Published: November 2015

Abstract
The filtering and prediction of the Madden–Julian oscillation (MJO) and relevant tropical waves is a contemporary issue with significant implications for extended range forecasting. This paper examines the process of filtering the stochastic skeleton model for the MJO with noisy partial observations. A nonlinear filter, which captures the inherent nonlinearity of the system, is developed and judicious model error is included. Despite its nonlinearity, the special structure of this filter allows closed analytical formulas for updating the posterior states and is thus computationally efficient. A novel strategy for adding nonlinear observational noise to the envelope of convective activity is designed to guarantee its nonnegative property. Systematic calibration based on a cheap single-column version of the stochastic skeleton model provides a practical guideline for choosing the parameters in the full spatially extended system. With these column-tuned parameters, the full filter has a high overall filtering skill for Rossby waves but fails to recover the small-scale fast-oscillating Kelvin and moisture modes. An effectively balanced reduced filter involving a simple fast-wave averaging strategy is then developed, which greatly improves the skill of filtering the moisture modes and other fast-oscillating modes and enhances the total computational efficiency. Both the full and the reduced filters succeed in filtering the MJO and other large-scale features with both homogeneous and warm pool cooling/moistening backgrounds. The large bias in filtering the solutions by running the perfect model with noisy forcing is due to the noise accumulation, which indicates the importance of including judicious model error in designing filters.
IL-1 Receptor Antagonist Inhibits Early Granulation Formation
Authors: Nicolli Elizabeth A. , Ghosh Ankona , Haft Sunny , Frank Renee , Saunders Cecil James , Cohen Noam , Mirza Natasha 
Published: November 2015

Purpose: Using a functional model of airway granulation tissue in laryngotracheal stenosis, we investigated changes in histopathology and inflammatory markers within granulation tissue in response to an interleukin-1 receptor antagonist (IL-1Ra). This study allows us to further delineate the immune response to wound healing and potentially identify treatment markers. Methods: Laryngotracheal complexes (LTCs) of donor mice underwent direct airway injury. The LTCs were transplanted into subcutaneous tissue of recipient mice in 2 groups: IL-1Ra treated and untreated. The IL-1Ra–treated arm received daily intraperitoneal injections of IL-1Ra for 3 weeks. The LTCs were then harvested. Granulation formation was measured. The mRNA expression of transforming growth factor (TGF) beta and IL-1 was quantified using real-time reverse transcript polymerase chain reaction. Results: There were statistically significant differences in lamina propria thickness. There were no statistically significant changes in mRNA expression of TGF-β and IL-1β between the treated and untreated specimens. Conclusions: Using a previously described murine model, we delineate inflammatory markers that can be targeted for potential therapy. While the levels of inflammatory markers do not change significantly, the lamina propria thickness shows that the effects of IL-1 have been inhibited. The early use of the IL-1Ra will inhibit the efficacy of IL-1 in the inflammatory cascade and can prevent early granulation formation.
Predictors of survival, nonrelapse mortality, and failure-free survival in patients treated for chronic graft-versus-host disease
Authors: Palmer Jeanne , Chai Xiaoyu , Pidala Joseph , Inamoto Yoshihiro , Martin Paul J. , Storer Barry , Pusic Iskra , Flowers Mary E. D. , Arora Mukta , Pavletic Steven Z. , Lee Stephanie J. 
Published: November 2015

Key Points
Survival of chronic GVHD patients was predicted by clinician-assessed response and changes in patient-reported outcomes. FFS was predicted by clinician-assessed response, changes in patient-reported outcomes, and the 2014 NIH response criteria.
Body size, swimming speed, or thermal sensitivity? Predator-imposed selection on amphibian larvae
Authors: Gvoždík Lumír , Smolinský Radovan 
Published: November 2015

AbstractBackgroundMany animals rely on their escape performance during predator encounters. Because of its dependence on body size and temperature, escape velocity is fully characterized by three measures, absolute value, size-corrected value, and its response to temperature (thermal sensitivity). The primary target of the selection imposed by predators is poorly understood. We examined predator (dragonfly larva)-imposed selection on prey (newt larvae) body size and characteristics of escape velocity using replicated and controlled predation experiments under seminatural conditions. Specifically, because these species experience a wide range of temperatures throughout their larval phases, we predict that larvae achieving high swimming velocities across temperatures will have a selective advantage over more thermally sensitive individuals.ResultsNonzero selection differentials indicated that predators selected for prey body size and both absolute and size-corrected maximum swimming velocity. Comparison of selection differentials with control confirmed selection only on body size, i.e., dragonfly larvae preferably preyed on small newt larvae. Maximum swimming velocity and its thermal sensitivity showed low group repeatability, which contributed to non-detectable selection on both characteristics of escape performance.ConclusionsIn the newt-dragonfly larvae interaction, body size plays a more important role than maximum values and thermal sensitivity of swimming velocity during predator escape. This corroborates the general importance of body size in predator–prey interactions. The absence of an appropriate control in predation experiments may lead to potentially misleading conclusions about the primary target of predator-imposed selection. Insights from predation experiments contribute to our understanding of the link between performance and fitness, and further improve mechanistic models of predator–prey interactions and food web dynamics.
Sharpening some core theorems of Nieto and Rodríguez-López with application to boundary value problem
Authors: Kutbi Marwan Amin , Alam Aftab , Imdad Mohammad 
Published: November 2015

AbstractIn this paper, we prove sharpened versions of some classical order-theoretic metrical fixed point theorems due to Nieto and Rodríguez-López (Order 22(3):223-239, 2005) using order-theoretic variants of completeness and continuity besides some another notions such as: the ICC property, the DCC property, and the MCC property. In this continuation, we further extend our results for Boyd-Wong type nonlinear contractions. Finally, as an application of our certain newly proved results, we establish the existence and uniqueness of solution of a first order periodic boundary value problem.
Algorithm based patient care protocol to optimize patient care and inpatient stay in head and neck free flap patients
Authors: O'Connell Daniel A. , Barber Brittany , Klein Max F. , Soparlo Jeff , Al-Marzouki Hani , Harris Jeffrey R. , Seikaly Hadi 
Published: November 2015

Objective To determine if rigid adherence (where medically appropriate) to an algorithm/checklist-based patient care pathway can reduce the duration of hospitalization and complication rates in patients undergoing head and neck reconstruction with free tissue transfer. Methods Study design was a retrospective case-control study of patients undergoing major head and neck cancer resections and reconstruction at a tertiary referral centre. The intervention was rigid adherence to a pre-existing care pathway including flow algorithms and multidisciplinary checklists incorporated into patient charting and care orders. 157 patients were enrolled prospectively and were compared to 99 patients in a historical cohort. Patient charts were reviewed and information related to the patient, procedure, and post-operative course was extracted. The two groups were compared for number of major and minor complications (using the Clavien-Dindo system) and length of stay in hospital. Results Comparing pre- and post-intervention groups, no significant difference was identified in duration of hospital stay (21.5 days vs. 20.5 days, p = 0.750), the rate of major complications was significantly higher in the pre-intervention cohort (25.3 % vs. 14.0 %, p = 0.031), the rate of minor complications was not significantly higher (34.3 % vs 30.8 %, p = 0.610). Conclusion Rigid adherence to our patient care pathway, and improved charting techniques including flow algorithms and multidisciplinary checklists has improved patient care by showing a significant reduction in the rate of major complications.
Autoimmune disorders in child psychiatry: keeping up with the field
Authors: Warrilow Adele , Morton Michael 
Published: November 2015

SummaryAutoimmune disorders in children and adolescents can have significant neuropsychiatric complications and there is growing interest in the association between autoimmune conditions and psychiatric syndromes, particularly in Down syndrome. Acute presentations with psychiatric symptoms require careful assessment in order to recognise and plan treatment of underlying autoimmune disease in collaboration with paediatric colleagues. Difficult treatment decisions arise in children with established autoimmune diagnoses and psychiatric symptoms that may be a result of neuroimmunological processes associated with their condition, psychiatric side-effects of drug treatments or psychopathology resulting from other factors in the history that may or may not have a direct relation to the autoimmune diagnosis. This article illustrates these complexities through discussion of specific autoimmune disorders and three case histories.
Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells
Authors: Naik Akshata R. , Kulkarni Sanjana P. , Lewis Kenneth T. , Taatjes Douglas J. , Jena Bhanu P. 
Published: November 2015

Abstract
Supramolecular cup-shaped lipoprotein structures called porosomes embedded in the cell plasma membrane mediate fractional release of intravesicular contents from cells during secretion. The presence of porosomes, have been documented in many cell types including neurons, acinar cells of the exocrine pancreas, GH-secreting cells of the pituitary, and insulin-secreting pancreatic β-cells. Functional reconstitution of porosomes into artificial lipid membranes, have also been accomplished. Earlier studies on mouse insulin-secreting Min6 cells report 100-nm porosome complexes composed of nearly 30 proteins. In the current study, porosomes have been functionally reconstituted for the first time in live cells. Isolated Min6 porosomes reconstituted into live Min6 cells demonstrate augmented levels of porosome proteins and a consequent increase in the potency and efficacy of glucose-stimulated insulin release. Elevated glucose-stimulated insulin secretion 48 hours after reconstitution, reflects on the remarkable stability and viability of reconstituted porosomes, documenting the functional reconstitution of native porosomes in live cells. These results, establish a new paradigm in porosome-mediated insulin secretion in β-cells.
Meeting report – Imaging the Cell
Authors: Moreau Violaine , Cordelières Fabrice P. , Poujol Christel , Sagot Isabelle , Saltel Frédéric 
Published: November 2015

ABSTRACT
Every two years, the French Society for Cell Biology (SBCF) organises an international meeting called ‘Imaging the Cell’. This year, the 8th edition was held on 24–26 June 2015 at University of Bordeaux Campus Victoire in the city of Bordeaux, France, a UNESCO World Heritage site. Over the course of three days, the meeting provided a forum for experts in different areas of cell imaging. Its unique approach was to combine conventional oral presentations during morning sessions with practical workshops at hosting institutes and the Bordeaux Imaging Center during the afternoons. The meeting, co-organised by Violaine Moreau and Frédéric Saltel (both INSERM U1053, Bordeaux, France), Christel Poujol and Fabrice Cordelières (both Bordeaux Imaging Center, Bordeaux, France) and Isabelle Sagot (Institut de Biochimie et Génétique Cellulaires, Bordeaux, France), brought together about 120 scientists including 16 outstanding speakers to discuss the latest advances in cell imaging. Thanks to recent progress in imaging technologies, cell biologists are now able to visualise, follow and manipulate cellular processes with unprecedented accuracy. The meeting sessions and workshops highlighted some of the most exciting developments in the field, with sessions dedicated to optogenetics, high-content screening, in vivo and live-cell imaging, correlative light and electron microscopy, as well as super-resolution imaging.
Songs as a Resource for Teaching English for Specific Purposes
Authors: Широких  , Shirokikh Anna 
Published: November 2015

The article considers songs as a significant resource for learning the English
language. Psychological, pedagogical and language reasons for using
the songs as a tool for teaching the language are considered. Physiology
and psychology of perception, context, and narrative, emotive and appellative
functions of this music genre as well as social and cultural components
are seen as important components of the song genre. The author realizes
that listening to songs should be reasonably limited and looks upon the criteria
of songs selection. The author gives an example of a lesson devoted
to the financial crisis and its consequences. The lesson is based on an
authentic narrative song on social and economic issues. The artistic and
language features of this text material are studied. Communicative tasks
are designed.
Dialogue of the Artist With the Audience: the Communicative Possibilities of Fine Arts
Authors: Бастрыкина  , Bastrykina T. 
Published: November 2015

The article deals with the problem of communication studies in the visual
arts, as well as the issues of transformation of the scope of knowledge
and aspects that determine the creative thinking and perception of various
forms of art. Aesthetic idea of art as a specific artistic image, in which and
through which the artist as a representative art expresses its relation to reality,
enters into a conversation with the destination. Concludes the reader,
viewer or listener. This is the deepest essence of the communication, which
is implemented as media through the web, created by the artist.
Multi-profile procedures for motor conversion disorders in children – a case report
Authors: Lenart-Domka Ewa , Pelc-Dymon Marzena 
Published: November 2015

CelPacjenci z zaburzeniami konwersyjnymi często prezentują deficyty ruchowe bez żadnej przyczyny o charakterze organicznym. Najczęściej spotykanymi objawami ruchowymi są drżenia, osłabienie kończyn oraz zaburzenia chodu. Prawidłowa diagnoza i leczenie oraz współpraca pacjenta i jego rodziny podczas terapii mają zasadniczy wpływ na osiągnięcie szybkiego wyzdrowienia. Celem tego artykułu jest zwrócenie uwagi na znaczenie wielodyscyplinarnego postępowania terapeutycznego w ruchowych zaburzeniach konwersyjnych u dzieci dla uzyskania optymalnych efektów leczenia zilustrowane opisem przypadku choroby.MetodaOpis przypadku: dziewięcioletni chłopiec z drżeniem kończyn, ataksją tułowia, zaburzeniami równowagi oraz znaczną niesprawnością w samodzielnej lokomocji na podłożu zaburzeń konwersyjnych został przyjęty na stacjonarny pobyt rehabilitacyjny z powodu braku postępu w dotychczasowym ponad czteromiesięcznym leczeniu obejmującym podawanie hydroxyzyny oraz nieregularne uczestnictwo w psychoterapii. Wdrożono jednoczasowo postępowanie obejmujące behawioralne modyfikacje w usprawnianiu ruchowym, psychoterapię indywidualną i rodzinną oraz leczenie farmakologiczne sertraliną. Szczególną uwagę zwrócono na uzyskanie akceptacji rodziców dziecka do prowadzonej skojarzonej formy terapii uznając, że dotychczasowe leczenie było niewydolne z powodu braku przekonania rodziców o psychogennych przyczynach objawów, skupieniu się na nadmiernym diagnozowaniu dziecka, co utrudniało znacznie prowadzenie prawidłowego leczenia.WynikiPo trzytygodniowym okresie kompleksowego leczenia pacjent odzyskał całkowicie sprawność ruchową, niezależność funkcjonalną oraz społeczną adekwatnie do swojego wieku.WnioskiRównoczesne wdrożenie wieloprofilowego postępowania jest skuteczną metodą leczenia ruchowych zaburzeń konwersyjnych u dzieci. Warunkiem jego powodzenia jest przekonanie rodziców o psychogennym podłożu objawów, konieczności podjęcia skojarzonego leczenia, co sprzyja uzyskaniu pełnej współpracy w procesie terapeutycznym.
Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells
Authors: Clara Renan Orsati , Assmann Nadine , Ramos Moreno Ana Carolina , Coimbra Janine Baptista , Nurenberger Nadine , Dettmer-Wilde Katja , Oefner Peter Josef , Campa Ana 
Published: November 2015

AbstractA key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-γ plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-γ. In general, IFN-γ affected KP in skin cells more than in melanoma cells, supporting IFN-γ roles in skin physiology and that of stromal cells in modulating the tumor microenvironment.
Age at menarche and diet among adolescents in slums of Nashik, India
Authors: Khopkar Sushama , Kulathinal Sangita , Virtanen Suvi M. , Säävälä Minna 
Published: November 2015

Abstract
Background and aim: The role of dietary patterns in determining age at menarche is insufficiently understood in low-income countries. The relationship between dietary patterns, particularly the consumption of oil, and age at menarche in a slum-dwelling adolescent population in India is examined.
Methods: Data were derived from a cross-sectional baseline survey and anthropometric measurements among 10- to 19-year-old adolescents (n=545, female respondents 272, of whom 160 were post-menarcheal) and a household survey in two slums in the city of Nashik, Western India. By using mixed effects linear regression models, the association between age at menarche and household-wise use of sources of animal protein and oil and fat is examined.
Results: Age at menarche (mean 13.7 years) in the slums studied was relatively high according to Indian standards. Age at menarche and the consumption of dairy products, meat, fish and eggs were not associated. The household per capita consumption of vegetable oil had an inverse association with a girl’s age at menarche, and there was an indication of a positive association between use of ghee (clarified butter) and age at menarche. These associations did not disappear when controlling for anthropometric status and socio-economic characteristics.
Conclusion: Intake of fats and foods that are important sources of protein among underprivileged households in India is low and reflected in the relatively late age at menarche. The potential differences in the association between various types of fatty acids, energy intake and age at menarche in conditions of undernutrition requires further prospective study.
The absolute center of finite groups
Authors: Meng Hangyang , Guo Xiuyun 
Published: November 2015

Abstract
In this paper we first investigate the relationship between the absolute center L(G)
and the Frattini subgroup Φ(G) for a finite group G, and then we describe the structure of
finite groups G satisfying L(G) ≤ Φ(G). For example, we
prove that a finite group G is an ℱ-group if and only
if G/L(G) is an ℱ-group, where ℱ is a
saturated formation containing Z
2.
Next we determine all finite groups X such that X/L(X) is isomorphic to
Z

p
ω
× Zp
, where ω is a positive integer and
Z

p
ω
is a cyclic group of order p
ω.
Expansion of conjugacy classes in PSL2(q)
Authors: Garion Shelly 
Published: November 2015

Abstract
For any conjugacy class 𝒞 in G = PSL2(q) we compute 𝒞2
and discuss whether or not 𝒞 contains a triple of elements whose
product is 1 which generate G. Moreover, we determine which
elements in G can be written as a product of two conjugate
elements that generate G.
Tantalum and vanadium substitution in hexagonal K0.3WO3 bronze: synthesis and characterization
Authors: Rahman Md. Shahidur , Murshed M. Mangir , Baabe Dirk , Gesing Thorsten M. 
Published: November 2015

Abstract
Polycrystalline samples of tantalum and vanadium single and double substituted hexagonal potassium tungsten bronzes (K-HTB’s) with nominal compositions of K0.3(W6+
0.7W5+
0.3–yTa5+
y)O3 (0≤y≤0.3), K0.3(W6+
0.7W5+
0.3–y V5+
y)O3 (0≤y≤0.18) and K0.3(W6+
0.7W5+
0.3–yTa5+
y/2V5+
y/2)O3 (0≤y≤0.3) were synthesized by solid state reactions in quartz tubes at 10–7 MPa and 1073 K. The applied synthesis condition allowed K0.3WO3 to crystallize in space group P6322, confirmed by X-ray powder diffration and Raman spectroscopic analyses. In this K-HTB composition, W5+ could fully be replaced by Ta5+, whereas V5+ could only be substituted up to y=0.16. The degree of W5+ substitution was explained in terms of second-order Jahn–Teller (SOJT) distortion of the d0 cations W6+, Ta5+ and V5+. The applied distortion index also demonstrates why a complete substitution of W5+ in K0.3(W6+W5+)O3 was allowed by a concomitant sharing of Ta5+ and V5+, which are statistically distributed on the W5+/W6+ sites. As W5+(d1) is not SOJT susceptible, it is also shown that the concentration of W5+ in tungsten bronzes plays an important role in the local WO6 octahedral symmetry as well as in its coordination.