bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethically constrained optimization of dynamic capabilities: towards sustainable global health
Authors: Ahen Frederick 
Published: November 2014

Purpose– This study aims to explain how sustainable global health presents an emerging new form of competition and socio-political and functional pressure for which strategic organizational renewal is a prerequisite for the organic resilience and co-evolution of pharmaceutical firms with their environment.Design/methodology/approach– Through a meta-theoretical analysis in which theories themselves become the unit of creative synthesis, a wider framework is developed to allow a comprehensive and nuanced reinterpretation of the neo-institutional theory and the resource-based view. In focus is the practical utility and relevance of such theories within emerging economies where pharmaceutical firms respond to market and institutional changes.Findings– The imperative for organizational change is very much dependent on the combination of ethically constrained managerial choices as well as entropic institutional pressures that allow firms to successfully adapt to their dynamic environment. This is achieved through legitimization and sustained competitive advantage, the results of innovation and contextually relevant differentiated value propositions.Social implications– Contrary to popular perceptions, recent developments demonstrate that the simultaneous pursuit of efficiency and ethical preferences is possible, irrespective of the institutional matrix within which change occurs. Managers should, therefore, tap into the niche opportunities offered by favorable entropic pressures.Originality/value– The novelty in this paper is the framework it provides for analyzing the massive role played by the micro-political power of managers and how the goals they pursue become fundamental to what the organization becomes as it coevolves with the turbulent era of emergent health needs.
An evaluation of an emotion regulation programme for people with an intellectual disability
Authors: McWilliams Jenna , de Terte Ian , Leathem Janet , Malcolm Sandra 
Published: November 2014

Purpose
– The purpose of this paper is to examine the effectiveness of the Transformers programme on individual's use of appropriate emotion regulation strategies.

Design/methodology/approach
– Five people with an intellectual disability participated in the Transformers programme and took part in the current study. The intervention was evaluated using the Profile of Anger Coping Skills (PACS) and incident reports. The PACS was completed by participants and their caregivers.

Findings
– The majority of participants demonstrated increases in self- and caregiver-reported use of appropriate emotion regulation strategies following their involvement in the Transformers programme. However, treatment gains were not always maintained at follow-up. Three of the participants also exhibited fewer incidents of challenging behaviour after taking part in the programme.

Originality/value
– Overall, the results provide preliminary support for the continued use of the Transformers programme with people with an intellectual disability who have emotion regulation difficulties. It is recommended that further research be carried out with a larger sample size, a control group, and a longer follow-up period.
Destination leadership: leadership for territorial development
Authors: Kozak Metin , Volgger Michael , Pechlaner Harald 
Published: November 2014

Purpose
This paper aims to provide an original body of work that presents and discusses the theory that destination leadership is about proactively shaping the future development of destinations and territories. This is the second part of the special issue of Tourism Review on destination leadership.

Design/methodology/approach
This editorial introduces the papers included and highlights a few general thoughts about the interplay between destination leadership and territorial development.

Findings
This introduction summarizes how the papers in this special issue contribute to two streams of research: first, the papers reflect on the necessity of adapting the specific form and style of destination leadership to the development status of a destination. Second, papers highlight that local stakeholders, local knowledge and the local context, in general, have a high impact on destination leadership.

Originality/value
By summarizing and condensing the various contributions to this special issue, the editorial introduction highlights that destination leadership is about proactively shaping the future of tourist destinations. Furthermore, it argues that this development needs to respect local networks, territorial characteristics, histories and contexts. Therefore, tailoring destination leadership to their own territories seems to be an essential success factor, and in the future, we may want to define Alpine destination leadership, island destination leadership, city destination leadership, etc.
The importance of being local: prioritizing knowledge in recruitment for destination development
Authors: Åberg Kajsa G. 
Published: November 2014

PurposeThe paper aims to illuminate the discrepancy between the need for knowledge as found in prior research and the requirements formulated by those taking part in destination development. The results are intended to contribute to further research on the role of knowledge in destination management when performed as a strategy for regional development.Design/methodology/approachBased on theories within epistemology and tourism, an interview structure was developed and used in 10 in-depth interviews, with a qualitative approach through open-ended questions. This was complemented by a mapping of specific background factors through enquiries with 23 respondents. The paper follows an explorative approach to illuminate one aspect within the research area of destination development.FindingsIt was found that when recruiting much significance is put on understanding the structures of involved actors and local rooting. In contrast to theoretical findings, specific knowledge was not a prioritized requirement, neither in tourism nor marketing. Hence, there is a gap between what is perceived as needed for destination development according to academia and how it is being performed by practitioners.Research limitations/implicationsThe study is limited in geography and context. Because the research design was showed to be successful in capturing significant aspects, it is proposed for use in further research.Practical implicationsThe paper deepens the understanding of factors explaining success and impediments of destination development. It underlines the need for bridging the gap between theory and practice.Originality/valueThis work addresses a vital, but not fully explored, aspect of an extensively implemented strategy for regional development.
Holiday intentions of Portuguese residents: a profile analysis for the years 2010 to 2014
Authors: Gomes João , Rodrigues Daniela , Montenegro Mónica , Costa Jorge 
Published: November 2014

Purpose
– This article aims to identify the holiday intentions of Portuguese residents, highlighting the importance and evolution of the internal market and the constraints that lead to a significant decrease of those taking holidays in recent years.

Design/methodology/approach
– The article is based on official tourism statistics and on an ongoing research by Instituto de Planeamento e Desenvolvimento do Turismo (IPDT) on “the holiday intentions of Portuguese residents regarding summer holidays”.

Findings
– The article finds that tourism in Portugal continues to grow and, in 2013, witnessed a record number of foreign tourists. Despite this success, domestic tourism showed a decrease, explained by the context of economic crisis that affects the country since 2009. However, other reasons such as professional commitments, and the avoidance of peak season for summer holidays, are also referred as reasons for not taking summer holidays.

Practical implications
– Results allow for a clear understanding of Portuguese residents’ profile regarding holiday intentions for summer holidays. The information presented and analyzed may be seen as very relevant in assisting decision makers in their strategy making process.

Originality/value
– This article seeks to illustrate the holiday intentions of the Portuguese residentes in a comparative study carried out over a three-year period. The results allow drawing conclusions about the tourism behavior of residents in Portugal during a severe economic crisis.
Tourist destination Azores
Authors: Fraga Vítor 
Published: November 2014

Purpose
– The purpose of this article is to demonstrate how the Azores are overcoming the challenges and less favourable conditions arising from the economic crisis.

Design/methodology/approach
– The article is based on information drawn from official national and regional sources.

Findings
– The positive evolution that was taking place in the Azorean tourism was naturally affected by the financial and economic crisis. In recent years, the Archipelago has been enjoying visibility as a tourist destination and is increasingly standing out as a unique destination due to its natural and landscape heritage, capable of captivating the most demanding tourists in terms of environmental quality.

Originality/value
– This article presents the perspective of the Azorean government and the responses given to the challenges caused by the economic crisis and the strategies outlined for the coming years.
Did the context of economic crisis affect the image of Portugal as a tourist destination?
Authors: Loureiro António 
Published: November 2014

Purpose
– The purpose of this paper is to reflect on how Portugal has dealt with economic crisis with reference to the tourism industry and from the perspective of a global distribution systems (GDS) operator.

Design/methodology/approach
– The article is based on information drawn from official information sources and relevant data from Travelport.

Findings
– In recent years, Portugal has developed a positive image in its source markets as a result of a refined strategy and because of the intrinsic quality of its offer and price competitiveness, thus making it an attractive destination. Now the challenge is to maintain the pace and actions in support of Portugal’s image, thereby ensuring its sustainability, with particular attention to security and the maintenance and cleanliness of public spaces.

Originality/value
– This article presents the perspective of a GDS operator with respect to the impacts of the Portuguese economic crisis on tourism and the responses made to address these challenges, thereby highlighting the resilience of tour operators.
Genome‐wide scans of genetic variants for psychophysiological endophenotypes: Introduction to this special issue of Psychophysiology
Authors: Iacono William G. 
Published: November 2014

AbstractThis special issue addresses the heritability and molecular genetic basis of 17 putative endophenotypes involving resting EEG power, P300 event‐related potential amplitude, electrodermal orienting and habituation, antisaccade eye tracking, and affective modulation of the startle eye blink. These measures were collected from approximately 4,900 twins and parents who provided DNA samples through their participation in the Minnesota Twin Family Study. Included are papers that detail the methodology followed, genome‐wide association analyses of single nucleotide polymorphisms and genes, analysis of rare variants in the human exome, and a whole genome sequencing study. Also included are 11 articles by leading experts in psychophysiology and genetics that provide perspective and commentary. A final integrative report summarizes findings and addresses issues raised. This introduction provides an overview of the aims and rationale behind these studies.
Molecular genetic psychophysiology: A perspective on the Minnesota contribution
Authors: de Geus Eco J. C. 
Published: November 2014

AbstractProgress in molecular genetic psychophysiology, on display in this special issue, shows that the affective and cognitive processes tagged by psychophysiological endophenotypes are highly polygenic. Identifying overlap in the genetic variants that influence these endophenotypes as well as behavioral traits can help us understand where in the brain, in which stage, and during what type of information processing these variants play a role in normal and abnormal behavior. The Minnesota Twin Family Study has demonstrated that the assessment of genetic markers and extensive psychophysiological experimentation can be done at a genetic epidemiological scale, that is, in thousands of subjects. A genome‐wide association meta‐analysis consortium consisting of psychophysiological research teams following the Minnesotan example is the obvious next step.
Do our “big data” in genetic analysis need to get bigger?
Authors: Baker Laura A. 
Published: November 2014

AbstractIndividual papers in this special issue might seem disappointing in their lack of discovery of specific genes of potential relevance to mental disorders. Yet, collectively, they yield information that could not be gleaned otherwise. Combining genome‐wide complex trait analysis and classic approaches to estimate heritability in the same sample, and supplementing genome‐wide association studies of common variants with exome and sequencing analyses, provides an unprecedented opportunity to examine major issues encountered in genetic research of complex traits, in ways not easily done with a series of unrelated studies using different samples, measures, and analytical approaches. Extending molecular genetic approaches to fully multivariate analyses will be an important future direction. These will require bigger analyses of even bigger big data, but will be essential in efforts to redefine psychopathology in the Research Domain Criteria (RDoC) approach promoted in the NIMH strategic plan.
Decomposing P300 to identify its genetic basis
Authors: Ford Judith M. 
Published: November 2014

AbstractIn this commentary, I explore reasons why it has been difficult to associate P300 amplitude with a gene or a single nucleotide polymorphism (SNP). I suggest we decompose P300 into the factors that contribute to it to get better traction on its genetic basis. Specifically, I note that we can improve the measurement of P300 to remove state‐dependent contributions by including more than one measurement occasion; we can identify and extract the neural components contributing to P300 amplitude by estimating EEG power in specific bands of the P300; we can adjust P300 for single‐trial variability; we can extract single‐trial variability; and we can refine the tasks to isolate the separate psychological processes that P300 reflects. In the end, each of these factors that contribute to the conglomerate P300 may be a separate endophenotype mapping onto a separate SNP or gene.
The genetic architecture of psychophysiological phenotypes
Authors: Munafò Marcus R. , Flint Jonathan 
Published: November 2014

AbstractIt is now clear that almost all complex traits have a highly polygenic component; that is, their genetic basis consists of relatively frequent risk alleles at a very large number of loci, each making a small contribution to variation, or disease susceptibility. This general conclusion appears to hold for intermediate phenotypes. Therefore, we should not expect these phenotypes to be associated with substantially larger effect sizes than conventional phenotypes. Instead, their usefulness is likely to lie in understanding the mechanism underpinning associations identified via genome‐wide association studies of conventional phenotypes.
Genetics, neuroscience, and psychopathology: Clothing the emperor
Authors: Patrick Christopher J. 
Published: November 2014

AbstractThis ground‐breaking series of articles reports findings from genome‐wide analyses of endophenotypic indicators of psychopathology including electrocortical activity/reactivity, electrodermal and startle blink responses, and neurocognitive task performance. Findings challenge the long‐held notion that endophenotypes more clearly reflect the impact of specific genes than referent clinical phenotypes. Implications for the concept of endophenotypes and biological psychopathology research more broadly are discussed.
Compact Shorted Stacked-Patch Antenna Integrated with Chip-Package Based on LTCC Technology
Authors: Li Yongjiu , Li Long , Dai Xiwang , Zhu Cheng , Huo Feifei , Dong Gang 
Published: November 2014

A low profile chip-package stacked-patch antenna is proposed by using low temperature cofired ceramic (LTCC) technology. The proposed antenna employs a stacked-patch to achieve two operating frequency bands and enhance the bandwidth. The height of the antenna is decreased to 4.09 mm (aboutλ/25 at 2.45 GHz) due to the shorted pin. The package is mounted on a 44 × 44 mm2ground plane to miniaturize the volume of the system. The design parameters of the antenna and the effect of the antenna on chip-package cavity are carefully analyzed. The designed antenna operates at a center frequency of 2.45 GHz and its impedance bandwidth(S11< -10 dB)is 200 MHz, resulting from two neighboring resonant frequencies at 2.41 and 2.51 GHz, respectively. The average gain across the frequency band is about 5.28 dBi.
Trends in Short- and Long-Term Survival Among Out-of-Hospital Cardiac Arrest Patients Alive at Hospital Arrival
Authors: Wong Michael K.Y. , Morrison Laurie J. , Qiu Feng , Austin Peter C. , Cheskes Sheldon , Dorian Paul , Scales Damon C. , Tu Jack V. , Verbeek P. Richard , Wijeysundera Harindra C. , Ko Dennis T. 
Published: November 2014

Background—
Out-of-hospital cardiac arrest (OHCA) is associated with a poor prognosis and poses a significant burden to the healthcare system, but few studies have evaluated whether OHCA incidence and survival have changed over time.

Methods and Results—

A population-based cohort study was conducted, including 34 291 OHCA patients >20 years of age who were transported alive to the emergency department of an acute-care hospital from April 1, 2002, to March 31, 2012, in Ontario, Canada. Patients with life-threatening trauma and those who died before hospital arrival were excluded. The overall age- and sex-standardized incidence of OHCA patients who were transported alive was 36 cases per 100 000 persons and did not significantly change over the study period. Cardiac risk factor prevalence increased significantly, whereas the rate of most cardiovascular conditions decreased significantly. The 30-day survival improved from 9.4% in 2002 to 13.6% in 2011; 1-year survival improved from 7.7% to 11.8% (
P
<0.001). Patients hospitalized in 2011 were significantly more likely to survive 30 days (adjusted odds ratio, 1.47 [95% CI, 1.22–1.77]) and 1 year (adjusted odds ratio, 1.55 [95% CI, 1.27–1.91]) compared with 2002. A significant interaction between temporal trends in survival improvement and age group was observed in which the improvement in survival was largest in the youngest age groups.

Conclusions—
OHCA patients who were transported alive are increasingly likely to have cardiovascular risk factors but less likely to have previous cardiovascular conditions. The overall incidence of OHCA patients transported to hospital alive did not change over the past decade. Short- and longer-term survival after OHCA has substantially improved, with younger patients experiencing the greatest improvement.
Recent Advances in Catalytic Asymmetric C–C Bond-Forming Reactions to Ketimines Promoted by Metal-Based Catalysts
Authors: Kumagai Naoya , Shibasaki Masakatsu 
Published: November 2014

Abstract
Recent progress (post-2010) in the field of metal-catalyzed asymmetric C–C bond-forming reactions using ketimines as electrophiles is reviewed. Compared with the corresponding aldimines, ketimines generally display less inherent reactivity and the two substituents on the imine carbon hamper prochiral-face-selection for enantioselective reactions. Recent advances with newly developed catalytic systems have resulted in several solutions to these long-standing problems. The construction of tetrasubstituted stereogenic centers is a crucial topic of asymmetric catalysis in the 21st century, and it is becoming increasingly clear that reactions using ketimines as electrophiles become one of the most important routes to access such chemical entities.
First Costa Rican record of Pacific Golden-Plover (Pluvialis fulva, Gmelin, 1789) (Aves: Charadriidae)
Authors: Sánchez Julio E. , Ramírez Johan Fernández , Sánchez César 
Published: November 2014

Here we report on the first observation of Pacific Golden Plover in Central America, from Costa Rica. An individual in winter plumage was observed on salts ponds along with several other roosting waders
Association Between Nailfold Capillaroscopy Findings and Pulmonary Function Tests in Patients with Systemic Sclerosis
Authors: Castellví Ivan , Simeón-Aznar Carmen Pilar , Sarmiento Mónica , Fortuna Ana , Mayos Mercedes , Geli Carme , Diaz-Torné César , Moya Patricia , De Llobet Josep Maria , Casademont Jordi 
Published: November 2014

Objective.To determine whether there is an association between different capillaroscopic findings and pulmonary function tests in systemic sclerosis (SSc).Methods.We did a retrospective observational study in a cohort of patients with SSc and early SSc. Patients with at least 1 nailfold videocapillaroscopy (NVC) magnified 120× were included. Pathological findings were giant capillaries, angiogenesis, and density loss. Findings were compared with lung function values: percent expected value of forced vital capacity (FVC), DLCO, and FVC/DLCO ratio. Other variables collected were sex and SSc type, and the presence of digital ulcers (DU), interstitial lung disease (ILD), scleroderma renal crisis, and/or pulmonary hypertension (PH).Results.Of 136 patients with SSc, 85 had undergone an NVC. The frequency of ILD, DU, and PH was 24.1%, 28.7%, and 17.2%, respectively. Data analysis showed that patients with density loss had worse FVC% (86.91 ± 19.42 vs 101.13 ± 16.06, p < 0.01) and DLCO% (71.43 ± 21.19 vs 85.9 ± 19.81, p < 0.01) compared to those without.Conclusion.Patients with loss of density present worse FVC and DLCO values. Prospective studies are warranted to determine whether NVC is useful for studying pulmonary function in SSc.