bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel indole derivative, 2‐{3‐[1‐(benzylsulfonyl)piperidin‐4‐yl]‐2‐methyl‐1H‐indol‐1‐yl}‐1‐(pyrrolidin‐1‐yl)ethenone, suppresses hedgehog signaling and drug‐resistant tumor growth
Authors: Jung Joo Hyun , Lee Hwayoung , Jeon Jiyeon , Lee Yoon Ji , Nada Hossam , Kim Minkyoung , Lee Hankyu , Bhattarai Deepak , Lee Kyeong , Ko Hyuk Wan 
Published: July 2024

AbstractThe Hedgehog (Hh) signaling pathway plays important roles in various physiological functions. Several malignancies, such as basal cell carcinoma (BCC) and medulloblastoma (MB), have been linked to the aberrant activation of Hh signaling. Although therapeutic drugs have been developed to inhibit Hh pathway‐dependent cancer growth, drug resistance remains a major obstacle in cancer treatment. Here, we show that the newly identified, 2‐{3‐[1‐(benzylsulfonyl)‐1,2,3,6‐tetrahydropyridin‐4‐yl]‐2‐methyl‐1H‐indol‐1‐yl}‐1‐(pyrrolidin‐1‐yl)ethenone analog (LKD1214) exhibits comparable potency to vismodegib in suppressing the Hh pathway activation. LKD1214 represses Smoothened (SMO) activity by blocking its ciliary translocation. Interestingly, we also identified that it has a distinctive binding interface with SMO compared with other SMO‐regulating chemicals. Notably, it maintains an inhibitory activity against the SmoD477H mutant, as observed in a patient with vismodegib‐resistant BCC. Furthermore, LKD1214 inhibits tumor growth in the mouse model of MB. Collectively, these findings suggest that LKD1214 has the therapeutic potential to overcome drug‐resistance in Hh‐dependent cancers.
The significant yet short‐term influence of research covidization on journal citation metrics
Authors: Zheng Xiang , Ni Chaoqun 
Published: July 2024

AbstractCOVID‐19 has emerged as a major research hotspot and trending topic in recent years, leading to increased publications and citations of related papers. While concerns exist about the potential citation boost in journals publishing these papers, the specifics are not fully understood. This study uses a generalized difference‐in‐differences approach to examine the impact of publishing COVID‐19 papers on journal citation metrics in the Health Sciences fields. Findings indicate that journals publishing COVID‐19 papers in 2020 received significantly higher citation premiums due to COVID‐19 in 2020 and continued to benefit from the premium in 2021 in certain fields. In contrast, journals that began publishing COVID‐19 papers in 2021 experienced weaker citation premiums. The citation premiums exhibit some negative spillover effect: Although the publication volume of non‐COVID‐19 papers also surged, these papers experienced insignificant or negative citation gains, even when published in the same journals as COVID‐19 papers. COVID‐19 papers published in high‐impact journals brought higher citation premiums than those in low‐impact journals in most fields, indicating a potential Matthew effect. These citation premiums can affect various citation‐based journal metrics, such as our simulated impact factor and SCImago Journal Rank, to different degrees. Compared to the simulated impact factor, other normalized journal metrics are less influenced by citation premiums. The results highlight a “gold rush” pattern in which early entrants establish their citation advantage in research hotspots and caution against using citation‐based metrics for research assessment.
Event‐triggered dynamic output feedback control for switched linear neutral systems under time‐varying delays and frequent asynchronism
Authors: Yan Rongrong , Wu Baowei , Wang Yue‐E , Liu Lili , Li Wenzi , Huang Liqiong 
Published: July 2024

AbstractThe study focuses on the event‐triggered dynamic output feedback control for a type of switched linear neutral systems under time‐varying delays and frequent asynchronism. Distinct from the existing literatures about asynchronous switching, which restricts the minimum dwell time, frequent switching is allowed to occur within each inter‐event interval by reason of average dwell time method. Then, concentrated on switched neutral time‐delay system, a novel sufficient condition is established under which proposed event‐triggered control scheme guarantees its the global uniform exponential stability by using the controller‐mode‐dependent Lyapunov functional together with dynamic output feedback controller. Subsequently, the sufficient criteria are deduced for co‐designing the dynamic output feedback controller and mode‐dependent event‐triggered mechanism. Additionally, it is proved that a positive minimum threshold on the inter‐event intervals exists, which eliminates Zeno phenomenon. In the end, a numerical simulation indicates the efficacy of the acquired results.
Red‐emitting 4‐methyl coumarin fused barbituric acid as an electrochemical sensor for catechol detection and probe for latent fingerprints
Authors: Yashyanaik Surendranaik , Venkatesh Talavara , Ereshnaik  , Vinuth Mirle 
Published: July 2024

AbstractHerein, we have reported a red‐emitting 4‐methyl coumarin fused barbituric acid azo dye (4‐MCBA) synthesized by conventional method. Density functional theory (DFT) studies of tautomer compounds were done using (B3LYP) with a basis set of 6‐31G(d,p). NLO analysis has shown that tautomer has mean first‐order hyperpolarisabilities (β) value of 1.8188 × 10−30 esu and 1.0470 × 10−30 esu for azo and hydrazone forms, respectively, which is approximately nine and five times greater than the magnitude of urea. 4‐MCBA exhibited two absorption peaks in the range of 290–317 and 379–394 nm, and emission spectra were observed at 536 nm. CV study demonstrated that the modified 4‐MCBA/MGC electrode exhibited excellent electrochemical sensitivity towards the detection of catechol and the detection limit is 9.39 μM under optimum conditions. The 4‐MCBA employed as a fluorescent probe for the visualisation of LFPs on various surfaces exhibited Level‐I to level‐II LFPs, with low background interference.
Non‐industrial production of therapeutic lentiviral vectors: How to provide vectors to academic CAR‐T
Authors: Keyer Viktoriya , Syzdykova Laura , Ingirbay Bakytkali , Sedova Elena , Zauatbayeva Gulzat , Kulatay Tolganay , Shevtsov Alexandr , Shustov Alexandr V. 
Published: July 2024

AbstractBringing effective cancer therapy in the form of chimeric antigen receptor technology to untapped markets faces numerous challenges, including a global shortage of therapeutic lentiviral or retroviral vectors on which all current clinical therapies using genetically modified T cells are based. Production of these lentiviral vectors in academic settings in principle opens the way to local production of therapeutic cells, which is the only economically viable approach to make this therapy available to patients in developing countries.The conditions for obtaining and concentrating lentiviral vectors have been optimized and described. The calcium phosphate precipitation method was found to be suitable for transfecting high cell‐density cultures, a prerequisite for high titers. We describe protocols for gradually increasing production from 6‐well plates to P100 plates, T‐175 flasks, and 5‐layer stacks while maintaining high titers, >108 transducing units. Concentration experiments using ultracentrifugation revealed the advantage of lower centrifugation speeds compared to competing protocols. The resulting batches of lentiviral vectors had a titer of 1010 infectious particles and were used to transduce primary human T lymphocytes generating chimeric antigen receptor T cells, the quality of which was checked and found potential applicability for treatment.
Novel allosteric glutaminase inhibitors with macrocyclic structure activity relationship analysis (part 2)
Authors: Lee Eun Ji , Jang Jiyoon , Cyriac Rajath , Yun Mi Ran , Kwon Yeongju , Jung Myoung Eun , Choi Gildon , Chae Chong Hak , Cho Byoung Chul , Lee Kwangho 
Published: July 2024

AbstractGlutamine‐addicted cancer metabolism is recently recognized as novel cancer target especially for KRAS and KEAP1 co‐occurring mutations. To identify more drug‐like GLS inhibitors, we report the amides in the wing macrocycles for GLS inhibition with unique SAR analysis. Although the amidotriazoles (amides in the wing) are in general less potent than those of acylaminothiadiazole analogs (reverse amides in the wing), macrocycle 4, 5, and 7 are selected as a potent macrocyclic GLS inhibitor in both biochemical and cell viability assays. Selected molecules result in partial reduction in intracellular glutamate levels in LR (LDK378‐resistant) cells which is consistent to their cells viability result. Finally, selected compounds reduce the growth of A549 and H460 cells which have co‐occurring mutations including KRAS and KEAP1. The putative binding mode of macrocycle 4 is also suggested using a molecular docking model.
Sustainability reporting in carbon‐intensive industries: Insights from a cross‐sector machine learning approach
Authors: Crocco Edoardo , Broccardo Laura , Alofaysan Hind , Agarwal Reeti 
Published: July 2024

AbstractDue to climate change concerns, academics and practitioners focus more on environmental management and sustainability. Accounting researchers have focused on corporate environmental disclosure and sustainability reporting in response to stakeholder demand for openness and accountability. Thus, scholarly studies on sustainability reporting have gained momentum with the frequent use of qualitative text analysis to assess company disclosures' completeness and quality. However, sustainability reporting research has major limitations wherein past studies have focused on certain sectors or qualitative content analysis. Coherently with the abovementioned gap, our study intends to examine sustainability reports of companies in agriculture, conventional energy, heavy industry and manufacturing, transport and automotive, and construction, the highly carbon‐intensive industries most vulnerable to physical climate damage and net‐zero transition risk. In doing so, the goal of the present research is to investigate sustainability reporting practice on a larger, cross‐sectoral scale by using automated, machine learning‐powered text analysis methods to complement and strengthen qualitative research results that scholars have previously obtained. The latent Dirichlet allocation topic modelling technique has been used to examine companies' sustainability efforts and identify industry‐specific subtopics based on quantitative distribution. The originality of our analysis lies in determining how companies prioritise issues in sustainability reports. By comparing reports from different industries, we also identify sector‐specific patterns and how organisations in highly carbon‐intensive industries that are most exposed to physical climate damage and net‐zero transition risk prioritise certain themes over others, as well as identifying what type of content is overall more prominently featured in reports, regardless of the industry. Our study adds to sustainability reporting literature by investigating a previously unstudied sample of sectors. Moreover, our study informs practitioners of existing sustainability reporting procedures. The subject model and a cross‐industry view can advise policymakers and industry of which themes are under‐disclosed and what industry‐specific rules may be desirable to suit sector‐specific needs.
Carbon accounting and integrated reporting for net‐zero business models towards sustainable development: A systematic literature review
Authors: Di Vaio Assunta , Zaffar Anum , Chhabra Meghna , Balsalobre‐Lorente Daniel 
Published: July 2024

AbstractThis study highlights the main concerns regarding firms' carbon accounting and decarbonization practices. Under institutional, legitimacy and stakeholder theories, this study analyses the linkages between carbon accounting outputs and integrated reporting (IR), as well as between disclosure assurance systems in the transition towards net‐zero business models (n‐ZBMs). This study emphasizes the awareness of accounting tools to be considered environmental and social measures due to decarbonization practices. This study developed a systematic literature review (SLR) of 433 English articles published in Scopus database and Google Scholar between the years 1990 and 2024. It is a consolidated methodological approach in the ‘sustainability accounting’ research field to fill the existing gaps that justify this study. The results of this study highlight that IR and carbon accounting awareness enhance firms' performance and have positive social and environmental impacts with the adoption of decarbonization practices towards n‐ZBMs through an improved understanding of stakeholders and regulatory pressures. This study is the first to explore the relationship between carbon accounting awareness and IR about the decarbonization practices, as well as the role of assurance in the transition for n‐ZBMs. This study tries to move from the concept of legitimacy of the decarbonization practices that firms aim to achieve through sustainable disclosure to the legitimacy of business models towards net‐zero emissions.
How do firms develop and financially benefit from green product innovation in a developing country? Roles of innovation orientation and green marketing innovation
Authors: Appiah Listowel Owusu , Essuman Dominic 
Published: July 2024

AbstractWhile previous research has explored the antecedents and outcomes of green product innovation, empirical evidence remains inconclusive. This study draws on the contingent natural resource–based view to conceptualize how innovation orientation enables firms to develop green product innovation to enhance financial performance, especially where they emphasize green marketing innovation. The study tests its hypotheses using primary survey data from 347 small and medium enterprises (SMEs) in Ghana and PROCESS as an analytical tool. The results suggest that innovation orientation has a positive relationship with green product innovation and that green product innovation mediates the relationship between innovation orientation and financial performance. Additional results indicate that green product innovation contributes more to financial performance under increasing levels of green marketing innovation. The article sheds new light on how firms can combine innovation orientation, green product innovation, and green marketing innovation to boost financial performance in a developing country.
It's like Jenga: A collaborative autoethnography study into facilitators' experiences of a person‐centred community of practice, focused on critical thinking skills for counselling and psychotherapy students
Authors: Blundell Peter , Hall Madeline 
Published: July 2024

AbstractBackgroundCommunities and groups based on person‐centred theoretical principles are often a core part of counselling and psychotherapy training within this modality, yet no research has been undertaken that considers these groups as a community of practice . Furthermore, no research has been undertaken that explores the impact of these groups when they are run alongside, rather than as part of, the curriculum.AimsThis study explores our experiences of facilitating a community of practice for trainee personcentred/experiential therapists that focused on critical thinking skills. This community was established over a 12‐week period and was attended by students from across 3‐year groups.MethodsUsing collaborative autoethnography to explore these encounters, we identify four key aspects of our experience of this community.ResultsThe following aspects were identified: (1) Fecund and Fruitful—A Space for Growth; (2) Freedom to Learn; (3) Jenga!—Navigating the Dimensions of Community Facilitator; and (4) Power and Control.DiscussionThis study centres on the idea of student‐centred learning as a way of challenging hegemonic notions of education and learning within higher educational settings.ConclusionThese findings could help others set up and facilitate other communities of practice based on person‐centred principles, in counselling and psychotherapy training, or other associated fields of study.
High Rotational Barrier Atropisomers
Authors: Fragkiadakis Michael , Thomaidi Maria , Stergiannakos Taxiarchis , Chatziorfanou Eleftheria , Gaidatzi Maria , Michailidis Barakat Alaelddin , Stoumpos Constantinos , Neochoritis Constantinos G. 
Published: July 2024

AbstractAtropisomers have attracted a great deal of attention lately due to their numerous applications in organic synthesis and to their employment in drug discovery. However, the synthetic arsenal at our disposal with which to access them remains limited. The research described herein is two‐pronged; we both demonstrate the use of MCR chemistry as a synthetic strategy for the de novo synthesis of a class of atropisomers having high barriers to rotation with the simultaneous insertion of multiple chiral elements and we study these unprecedented molecular systems by employing a combination of crystallography, NMR and DFT calculations. By fully exploiting the synthetic capabilities of our chemistry, we have been able to monitor a range of different types of interaction, i. e. π‐π, CH–π, heteroatom‐π and CD–π, in order to conduct structure‐property studies. The results could be applied both to atroposelective synthesis and in drug discovery.
Mechanochemical Synthesis of Corannulene Flanked N‐heterocyclic Carbene (NHC) Precursors and Preparation of Their Metal Complexes
Authors: Hum Gavin , Muzammil Ezzah M. , Li Yongxin , García Felipe , Stuparu Mihaiela C. 
Published: July 2024

AbstractThe synthesis of new compounds is an important pillar for the advancement of the field of chemistry and adjacent fields. In this regard, over the last decades huge efforts have been made to not only develop new molecular entities but also more efficient sustainable synthetic methodologies due to the increasing concerns over environmental sustainability. In this context, we have developed synthetic routes to novel corannulene flanked imidazolium bromide NHC precursors both in the solid‐state and solution phases. Our work presents a comprehensive comparative study of mechanochemical routes and conventional solution‐based methods. Green metrics and energy consumption comparison were performed for both routes revealing ball‐milling generation of these compounds to be an environmentally greener technique to produce such precursors compared to conventional solvent‐based methods. In addition, we have demonstrated proof‐of‐concept of the herein reported corannulene flanked NHCs to be robust ligands for transition metals and their ligand substitution reactions.
Intramolecular Nucleophilic Vinylic Substitution (SNV) by Carbon Nucleophiles: Conformationally Directed Formation of Dienes from N,N’‐Diallyl Ureas
Authors: van Veen Branca C. , Clayden Jonathan 
Published: July 2024

AbstractNucleophilic vinylic substitution (SNV) by carbon nucleophiles allows the formation of vinylic C−C bonds without transition metal catalysts. In this paper, we show that tethering two alkenes together through a urea linkage can lead to the formation of a diene by an intramolecular SNV reaction. The starting materials are fully substituted N,N’‐diallyl ureas; the reaction proceeds in the presence of base, and entails a cascade of deprotonations, reprotonations, and an SNV reaction of an allylic carbanion on a rare electrophile: a vinylic urea. As a result, two allylic substituents couple to form a diene, despite the fact that neither is activated towards electrophilic attack. The reaction is tolerant of significant steric bulk, and exhibits regioselectivity with unsymmetrical diallyl ureas: β‐substituted allyl groups invariably behave as nucleophiles, while electrophilic behavior may be enforced by the use of an E‐vinylic urea substituent that cannot be deprotonated under the reaction conditions.
Ion migration – innovative low‐cost experiments
Authors: Ducci Matthias 
Published: July 2024

AbstractIm Beitrag werden neu entwickelte Low‐Cost‐Experimente zur Demonstration der Ionenwanderung im elektrischen Feld präsentiert. Als Versuchsgefäß dient ein Blister aus dem Zeichenbedarf. Die Salze werden zunächst in Alginatbällchen eingeschlossen, aus denen sie sukzessive in die umgebende Flüssigkeit diffundieren. Hierzu werden auch Substanzen mit fluoreszierenden Ionen verwendet
Breast segmentation in infrared thermography from characteristical inframammary shape
Authors: Alvarez‐Padilla Francisco J. , Flores‐Nunez Jorge L. , Alvarez‐Padilla Juan R. , Gonzalez Francisco J. , Oceguera‐Villanueva Antonio , Gutierrez‐Quiroz Brian A. 
Published: July 2024

AbstractInfrared thermography is gaining relevance in breast cancer assessment. For this purpose, breast segmentation in thermograms is an important task for performing automatic image analysis and detecting possible temperature changes that indicate the presence of malignancy. However, it is not a simple task since the breast limit borders, especially the top borders, often have low contrast, making it difficult to isolate the breast area. Several algorithms have been proposed for breast segmentation, but these highly depend on the contrast at the lower breast borders and on filtering algorithms to remove false edges. This work focuses on taking advantage of the distinctive inframammary shape to simplify the definition of the lower breast border, regardless of the contrast level, which indeed also provides a strong anatomical reference to support the definition of the poorly marked upper boundary of the breasts, which has been one of the major challenges in the literature. In order to demonstrate viability of the proposed technique for an automatic breast segmentation, we applied it to a database with 180 thermograms and compared their results with those reported by others in the literature. We found that our approach achieved a high performance, in terms of Intersection over Union of 0.934, even higher than that reported by artificial intelligence algorithms. The performance is invariant to breast sizes and thermal contrast of the images.
Eco‐Friendly Transformation of Bioethanol into Ethylene over Bimetallic Nickel‐Copper Catalysts
Authors: Gaitán Chavarría Emily , Picado Espinoza Thamara , Durán Herrera Esteban , Miranda Morales Bárbara Cristina 
Published: July 2024

AbstractThe conversion of bioethanol to ethylene in gas phase and atmospheric pressure was investigated over γ‐Al2O3 supported copper and nickel catalysts. These catalysts were prepared by co‐precipitation and pre‐treated with hydrogen at 450 °C. Six catalysts were studied at 450 °C under a nitrogen atmosphere. It was found that the monometallic Cu/γ‐Al2O3 catalyst exhibited the highest ethylene concentration, with a selectivity of around 90 %. The bioethanol conversion obtained was between 57 %‐86 %. Another catalyst that exhibited high concentration values was the NiCu1 : 7 bimetallic catalyst. The catalysts were characterised using XRD, SEM, EDS, TEM, TGA, FTIR, Raman, and N2‐physisoption techniques. Furthermore, the Cu/γ‐Al2O3 catalyst was studied under different reduction temperatures and gas flow conditions. It was found that the catalysts reduced at 350 °C and 35 ml/min N2 flow presented ethylene concentrations between (0.18–0.21) g/L. Moreover, the catalyst deactivation was identified to be first order and the equation of the Cu/γ‐Al2O3 catalyst deactivation model was determined. Carbonaceous deposits over the used sample were not detected by Raman and FTIR. It was determined that the Cu/γ‐Al2O3 catalyst deactivation could be mainly attributed to the blocking of the catalytic sites by strongly adsorbed compounds and hydroxylation of the catalyst surface.