bluuebunny/crossref_metadata_2025_split huggingface dataset:
A histomorphometric assessment of collagen‐stabilized anorganic bovine bone mineral in maxillary sinus augmentation – a randomized controlled trial in sheep
Authors: Alayan Jamil , Vaquette Cedryck , Saifzadeh Siamak , Hutmacher Dietmar , Ivanovski Saso 
Published: July 2015

AbstractObjectiveTo histomorphometrically compare the use of collagen‐stabilized anorganic bovine bone (ABBM‐C) (test) to anorganic bovine bone + autogenous bone (ABBM + AB) (control) in maxillary sinus augmentation.Materials and methodsNine sheep underwent bilateral sinus augmentation. Each sinus was randomized to receive either control or test bone graft. Three animals were sacrificed at 8 weeks, and six animals were sacrificed at 16 weeks post‐grafting. The 18 sinuses were processed for histomorphometry, which assessed the area fraction of new bone (%NB), residual graft (%RG) and soft tissue components (% STM), as well as graft particle osseointegration (% OI), within three zones equally distributed from the augmented sinus floor.ResultsAt week 16, a significant increase in %NB was evident across all three zones in the control group when compared to week 8. A significantly greater %NB was evident in the control group when compared to the test group in zones 2 (P < 0.001) and 3 (P < 0.001). There was a significant increase in %OI in week 16 when compared to week 8 across all three zones in the control group (P < 0.001). %OI in the control group was significantly greater across all three zones when compared to the test group at week 16 (P < 0.001). Zone was found to be a significant main effect (P < 0.001) that was independent of time and treatment with decreasing %OI in distant zones. %RG did not significantly change with time for both groups. There was a significant reduction in %ST in week 16 when compared to week 8 across all three zones in the control group (P < 0.001). %ST in the test group was significantly greater across all zones when compared to the control group at week 16 (P < 0.001).ConclusionBoth groups exhibited very similar histomorphometric measurements in the zones proximal to the resident sinus wall. The % NB and % OI were greatest in the zones proximal to resident bony walls and gradually decreased as the distance from the proximal walls increased. There was greater % NB and % OI in the control group when compared to the test group in the distant zone.
Submerged flapless technique vs. conventional flap approach for implant placement: experimental domestic pig study with 12‐month follow‐up
Authors: Pérez‐Albacete Martínez Carlos , Vlahović Zoran , Šćepanović Miodrag , Videnović Goran , Barone Antonio , Calvo‐Guirado José Luis 
Published: July 2015

AbstractObjectivesThe aim of our study was to compare osseointegration and peri‐implant crestal bone resorption in submerged flapless and conventional flap surgery over a 12‐month follow‐up.Materials and methodsThe study used five domestic pigs. Implants were inserted 9 weeks after tooth extraction. Each animal received six implants in the mandible, following a split‐mouth design: one side was treated using a flapless technique using mini‐incisions, while a flap was raised on the other. The animals were sacrificed at 2 weeks, 1, 3, 6 and 12 months after implant placement. Radiographic images were taken to analyze crestal bone loss, and samples were extracted for histopathological and bone‐to‐implant contact (BIC) analyses.ResultsSignificantly, greater crestal bone loss (P = 0.005) was obtained in the flap group compared with the flapless group. The flapless group presented significantly higher percentages of BIC (P < 0.05) at 3, 6 and 12 months compared with the conventional flap group.ConclusionsWithin the limitations of this experimental animal study, it may be concluded that the type of surgery (flap or flapless) affects peri‐implant bone preservation and osseointegration of regular platform implants. Flapless surgery is associated with peri‐implant crestal bone preservation. Flapless surgery in combination with submerged implants allows higher osseointegration values.
Intramuscular water movement during and after isometric muscle contraction: evaluation at different exercise intensities
Authors: Yanagisawa Osamu , Kurihara Toshiyuki 
Published: July 2015

SummaryWe aimed at evaluating the effect of isometric muscle contraction on intramuscular water movement at different exercise intensities. Seven men performed 1‐min isometric ankle dorsiflexion (20% and 50% maximal voluntary contractions [MVCs]) with a non‐magnetic custom‐made dynamometer, inside a magnetic resonance (MR) device. Axial diffusion‐weighted images were obtained before, during and at 1–20 min (1‐min interval) after the exercise to calculate the apparent diffusion coefficient (ADC) of the tibialis anterior. Under the same exercise condition, the concentration change of total haemoglobin (Hb) and myoglobin (Mb) (total Hb/Mb) within the tibialis anterior was assessed by performing near‐infrared spectroscopy before, during and after the exercise outside the MR device. The 20% MVC exercise significantly increased the ADC only at 1 min postexercise (P<0·01), whereas the ADC significantly increased during and at 2–20 min after the 50% MVC exercise (P<0·01). The 20% MVC exercise decreased the total Hb/Mb during exercise (P<0·01), but the value significantly increased at 1 min postexercise (P<0·01). The total Hb/Mb significantly decreased during the 50% MVC exercise, but significantly increased at 1–5 min postexercise (P<0·01). One‐minute moderate‐intensity isometric exercise activates intramuscular water movement during and after the exercise. This activation was found even after a low‐intensity exercise, but the effect was small and did not last long. The effect of intramuscular hyperaemia on the postexercise ADC elevation may be limited to the very early period after low‐ to moderate‐intensity exercises.
Three‐phase bone scintigraphy for diagnosis of Charcot neuropathic osteoarthropathy in the diabetic foot – does quantitative data improve diagnostic value?
Authors: Fosbøl M. , Reving S. , Petersen E. H. , Rossing P. , Lajer M. , Zerahn B. 
Published: July 2015

SummaryAimTo investigate whether inclusion of quantitative data on blood flow distribution compared with visual qualitative evaluation improve the reliability and diagnostic performance of 99 mTc‐hydroxymethylene diphosphate three‐phase bone scintigraphy (TPBS) in patients suspected for charcot neuropathic osteoarthropathy (CNO) of the foot.MethodA retrospective cohort study of TPBS performed on 148 patients with suspected acute CNO referred from a single specialized diabetes care centre. The quantitative blood flow distribution was calculated based on the method described by Deutsch et al. All scintigraphies were re‐evaluated by independent, blinded observers twice with and without quantitative data on blood flow distribution at ankle and focus level, respectively. The diagnostic validity of TPBS was determined by subsequent review of clinical data and radiological examinations.ResultsA total of 90 patients (61%) had confirmed diagnosis of CNO. The sensitivity, specificity and accuracy of three‐phase bone scintigraphy without/with quantitative data were 89%/88%, 58%/62% and 77%/78%, respectively. The intra‐observer agreement improved significantly by adding quantitative data in the evaluation (Kappa value 0·79/0·94). The interobserver agreement was not significantly improved.ConclusionAdding quantitative data on blood flow distribution in the interpretation of TBPS improves intra‐observer variation, whereas no difference in interobserver variation was observed. The sensitivity of TPBS in the diagnosis of CNO is high, but holds limited specificity. Diagnostic performance does not improve using quantitative data in the evaluation. This may be due to the reference intervals applied in the study or the absence of a proper gold standard diagnostic procedure for comparison.
An echo‐planar imaging sequence is superior to a steady‐state free precession sequence for visual as well as quantitative assessment of cardiac magnetic resonance stress perfusion
Authors: Ahlander Britt‐Marie , Maret Eva , Brudin Lars , Starck Sven‐Ake , Engvall Jan 
Published: July 2015

SummaryBackgroundTo assess myocardial perfusion, steady‐state free precession cardiac magnetic resonance (SSFP, CMR) was compared with gradient‐echo–echo‐planar imaging (GRE‐EPI) using myocardial perfusion scintigraphy (MPS) as reference.MethodsCardiac magnetic resonance perfusion was recorded in 30 patients with SSFP and in another 30 patients with GRE‐EPI. Timing and extent of inflow delay to the myocardium was visually assessed. Signal‐to‐noise (SNR) and contrast‐to‐noise (CNR) ratios were calculated. Myocardial scar was visualized with a phase‐sensitive inversion recovery sequence (PSIR). All scar positive segments were considered pathologic. In MPS, stress and rest images were used as in clinical reporting. The CMR contrast wash‐in slope was calculated and compared with the stress score from the MPS examination. CMR scar, CMR perfusion and MPS were assessed separately by one expert for each method who was blinded to other aspects of the study.ResultsVisual assessment of CMR had a sensitivity for the detection of an abnormal MPS at 78% (SSFP) versus 91% (GRE‐EPI) and a specificity of 58% (SSFP) versus 84% (GRE‐EPI). Kappa statistics for SSFP and MPS was 0·29, for GRE‐EPI and MPS 0·72. The ANOVA of CMR perfusion slopes for all segments versus MPS score (four levels based on MPS) had correlation r = 0·64 (SSFP) and r = 0·96 (GRE‐EPI). SNR was for normal segments 35·63 ± 11·80 (SSFP) and 17·98 ± 8·31 (GRE‐EPI), while CNR was 28·79 ± 10·43 (SSFP) and 13·06 ± 7·61 (GRE‐EPI).ConclusionGRE‐EPI displayed higher agreement with the MPS results than SSFP despite significantly lower signal intensity, SNR and CNR.
Test–retest reliability of skeletal muscle oxygenation measurements during submaximal cycling exercise in patients with chronic heart failure
Authors: Niemeijer Victor M. , Spee Ruud F. , Jansen Jasper P. , Buskermolen Antonetta B. C. , van Dijk Thomas , Wijn Pieter F. F. , Kemps Hareld M. C. 
Published: July 2015

SummaryThe potential purpose of near‐infrared spectroscopy (NIRS) as a clinical application in patients with chronic heart failure (CHF) is the identification of limitations in O2 delivery or utilization during exercise. The objective of this study was to evaluate absolute and relative test–retest reliability of skeletal muscle oxygenation measurements in patients with CHF. Thirty patients with systolic heart failure (left ventricular ejection fraction 31 ± 8%) performed 6‐min constant‐load cycling tests at 80% of the anaerobic threshold (AT) with tissue saturation index (TSI) measurement at the vastus lateralis. Tests were repeated after 10 ± 5 days to evaluate reliability. Absolute reliability was assessed with limits of agreement (LoA, expressed as bias ± random error) and coefficients of variation (CV) for absolute values (LoA range: 0·4 ± 6·2% to 0·6 ± 7·9%; CV range: 4·7–7·1%), amplitudes (LoA range −0·5 ± 5·8% to −0·7 ± 6·8%; CV range: 26·2–42·1%), onset and recovery kinetics (mean response times; LoA 0·4 ± 9·5 s, CV 23·5% and LoA −5·8 ± 50·8 s, CV 67·4% respectively) and overshoot characteristics (CV range 45·7–208·6%). Relative reliability was assessed with intraclass correlation coefficients for absolute values (range 0·74–0·90), amplitudes (range 0·85–0·92), onset and recovery kinetics (0·53 and 0·51, respectively) and overshoot characteristics (range 0·17–0·74). In conclusion, absolute reliability of absolute values and onset kinetics seems acceptable for serial within‐subject comparison, and as such, for evaluation of treatment effects. Absolute reliability of amplitudes and recovery kinetics is considered unsatisfactory. Relative reliability of absolute values and amplitudes is sufficient for purposes of physiological distinction between patients with CHF. Despite lower relative reliability, kinetics may still be useful for clinical application.
Treating fibrosing cholestatic hepatitis C with sofosbuvir and ribavirin: a matched analysis
Authors: Saab Sammy , Jimenez Melissa , Bau Sherona , Goo Tyralee , Zhao Difan , Durazo Francisco , Han Steven , El Kabany Mohammed , Kaldas Fady , Tong Myron J. , Busuttil Ronald W. 
Published: July 2015

AbstractBackgroundFibrosing cholestatic hepatitis (FCH) is an uncommon but potentially fatal complication of recurrent hepatitis C (HCV) in liver transplant recipients.MethodsWe matched the treatment outcomes of 10 liver transplant recipients who developed FCH with those of 10 recipients with recurrent HCV without FCH treated with sofosbuvir and ribavirin.ResultsBaseline mean alanine transaminase, aspartate transaminase, alkaline phosphatase, and total bilirubin were 186 U/L, 197 U/L, 243 U/L, and 6.7 mg/dL, respectively, in the FCH recipients and 82 U/L, 60 U/L, 110 U/L, and 0.99 mg/dL, respectively, in non‐FCH recipients. The sustained viral response in FCH and non‐FCH recipients was 40% and 80%, respectively. One‐yr patient and graft survival rates were 90% and 80%, respectively, in FCH recipients, and 100% in non‐FCH recipients. Seven FCH and six non‐FCH recipients were treated for anemia with blood transfusion and/or erythropoietin growth factors.ConclusionOur results suggest that the use of sofosbuvir and ribavirin is effective and tolerable in liver transplant recipients treated for recurrent FCH. There is a trend of lower sustained viral response, patient survival, and graft survival in the FCH recipients.
Advantages of dual hypothermic oxygenated machine perfusion over simple cold storage in the preservation of liver from porcine donors after cardiac death
Authors: Li Peng , Liu Yong‐Feng , Yang Lei 
Published: July 2015

AbstractAimsWe have compared hypothermic oxygenated machine perfusion (HOPE) with simple cold storage (SCS) in liver preservation with a porcine model of donor after cardiac death (DCD).MethodsA DCD model was developed in 10 hybrid pigs by apnea. Livers were harvested after 30 min of warm ischemia (WI) and randomly preserved using HOPE (HOPE group, five pigs, dual perfusion via portal vein and hepatic artery) or SCS (SCS group, five pigs) methods. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose, lactic acid, and pyruvic acid were measured by microdialysis analyzer.ResultsHistological morphology of liver tissue was significantly affected by 30 min of WI. HOPE significantly delayed histological morphology change and cell apoptosis. Release of ALT and AST was significantly higher in SCS group compared to HOPE group (p < 0.05) during 12–18 h of preservation. Levels of glucose, lactic acid, and pyruvic acid in HOPE group were significantly closer to baseline than that in SCS group after 18 h of preservation (p < 0.05).ConclusionsHOPE is supported for the preservation of liver from DCD due to significant improvement in the prevention of hepatocellular damage and protection of liver function and metabolic activity compared with SCS.
Implementation process of all periodontal competences and assessments as proposed in the 2010 European consensus meeting into the existing local undergraduate curriculum
Authors: Schoonheim‐Klein M. , Ong T. S. , Loos B. G. 
Published: July 2015

AbstractAimTo report on our implementation process within the existing local curriculum of all periodontal competences and assessments as proposed in the 2010 European consensus meeting.Material and methodIn 2011, a workshop for all teaching staff at the Department of Periodontology, ACTA, an education and assessment blueprint, was developed to test for missing education and assessment of European competences, divided into seven domains. This was repeated in 2013. An oral evaluation of the staff followed both meetings.ResultsIt appeared that eight of 58 (14%) European competences were not taught, and 21 (35%) competences were not assessed. After evaluation of the results on the actual curriculum and the assessment programme, shared decisions were made about how to teach and assess the missing competences within the local periodontal educational programme. The second workshop in 2013 revealed still 8 (14%) competences were not taught and 8 (14%) competences were not assessed. Staff appreciated the used method of validation; it gave insight and an overview of the curriculum. The existence of the European consensus report for undergraduate periodontal education, based on seven domains, has been instrumental and essential.ConclusionThe development of a blueprint from the education programme and concomitant assessment methods in periodontology by participating teaching staff gives a validation and appreciation of the curriculum and will improve the quality of education and assessment. It is advised that for quality control of the curriculum, dental schools could do this exercise for all their specialties if European consensus reports exist.
A new genus of Cyrtoscydmini (Coleoptera: Staphylinidae: Scydmaeninae) from Japan
Authors: Jałoszyński Paweł 
Published: July 2015

AbstractRutaraphes shikokuensis gen. et sp. nov. is described from Shikoku, Japan. The new taxon belongs to a group of genera characterized by the lateral sutures demarcating the submentum and is most similar to Neuraphes and Scydmoraphes. Morphological structures of Rutaraphes are illustrated and possible affinities with other genera of Cyrtoscydmini are discussed. Keys to identification of Palearctic and Japanese genera of Cyrtoscydmini are given. Including Rutaraphes, 14 genera of Scydmaeninae are currently known to occur in Japan.
De novo KCNT1 mutations in early‐onset epileptic encephalopathy
Authors: Ohba Chihiro , Kato Mitsuhiro , Takahashi Nobuya , Osaka Hitoshi , Shiihara Takashi , Tohyama Jun , Nabatame Shin , Azuma Junji , Fujii Yuji , Hara Munetsugu , Tsurusawa Reimi , Inoue Takahito , Ogata Reina , Watanabe Yoriko , Togashi Noriko , Kodera Hirofumi , Nakashima Mitsuko , Tsurusaki Yoshinori , Miyake Noriko , Tanaka Fumiaki , Saitsu Hirotomo , Matsumoto Naomichi 
Published: July 2015

SummaryKCNT1 mutations have been found in epilepsy of infancy with migrating focal seizures (EIMFS; also known as migrating partial seizures in infancy), autosomal dominant nocturnal frontal lobe epilepsy, and other types of early onset epileptic encephalopathies (EOEEs). We performed KCNT1‐targeted next‐generation sequencing (207 samples) and/or whole‐exome sequencing (229 samples) in a total of 362 patients with Ohtahara syndrome, West syndrome, EIMFS, or unclassified EOEEs. We identified nine heterozygous KCNT1 mutations in 11 patients: nine of 18 EIMFS cases (50%) in whom migrating foci were observed, one of 180 West syndrome cases (0.56%), and one of 66 unclassified EOEE cases (1.52%). KCNT1 mutations occurred de novo in 10 patients, and one was transmitted from the patient's mother who carried a somatic mosaic mutation. The mutations accumulated in transmembrane segment 5 (2/9, 22.2%) and regulators of K+ conductance domains (7/9, 77.8%). Five of nine mutations were recurrent. Onset ages ranged from the neonatal period (<1 month) in five patients (5/11, 45.5%) to 1–4 months in six patients (6/11, 54.5%). A generalized attenuation of background activity on electroencephalography was seen in six patients (6/11, 54.5%). Our study demonstrates that the phenotypic spectrum of de novo KCNT1 mutations is largely restricted to EIMFS.
Do ‘Good Governance’ Codes Enhance Financial Accountability? Evidence from Managerial Pay in Dutch Charities
Authors: Perego Paolo , Verbeeten Frank 
Published: July 2015

AbstractThis paper examines the initial impact of a ‘good governance’ code for charitable organisations that was promulgated in the Netherlands in 2005. Data are gathered from publicly available annual reports of 138 charities in the post‐implementation phase of the code (2005–2008). We first examine whether the code altered charities’ governance structures. Next, we investigate managerial pay as a key aspect of discharging financial accountability because prior literature focused on ‘excessive’ compensation. The findings indicate that a strengthened governance structure positively affects the likelihood of disclosing information concerning managerial pay, as well as mitigating managerial pay level.
Accountability and Transparency in English Local Government: Moving from ‘Matching Parts’ to ‘Awkward Couple’?
Authors: Ferry Laurence , Eckersley Peter , Zakaria Zamzulaila 
Published: July 2015

AbstractAlthough excessive transparency and accountability demands can have a counterproductive effect on organisational performance (Bovens, 2005), longstanding hierarchical accountability structures to ensure financial conformance in English local government continue to endure. Interestingly however, the previously top‐down regime for performance accountability in English local government has been replaced by bottom‐up mechanisms such as greater transparency and a more open market for public services. Using the framework developed by Hood (2010), this paper will show how such reforms mean that transparency and accountability are moving from being ‘matching parts’ to an ‘awkward couple’, and how this has significant implications for public services.
Preventive effects of astaxanthin on diethylnitrosamine‐induced liver tumorigenesis in C57/BL/KsJ‐db/db obese mice
Authors: Ohno Tomohiko , Shimizu Masahito , Shirakami Yohei , Miyazaki Tsuneyuki , Ideta Takayasu , Kochi Takahiro , Kubota Masaya , Sakai Hiroyasu , Tanaka Takuji , Moriwaki Hisataka 
Published: July 2015

AimObesity and its related metabolic abnormalities, including oxidative stress and adipokine imbalance, are involved in liver carcinogenesis. The aim of the present study was to examine the effects of astaxanthin, a powerful biological antioxidant, on the development of diethylnitrosamine (DEN)‐induced liver tumorigenesis in C57BL/KsJ‐db/db (db/db) obese mice.MethodsMale db/db mice were given a single i.p. injection of DEN (25 mg/kg bodyweight) at 2 weeks of age, and, subsequently, from 4 weeks of age, they were fed a diet containing 200 p.p.m. astaxanthin throughout the experiment.ResultsTwenty weeks of astaxanthin administration significantly inhibited the development of hepatocellular neoplasms (liver cell adenoma and hepatocellular carcinoma) and the hepatic expression of cyclin D1 mRNA compared with the basal diet group in DEN‐treated db/db mice. Astaxanthin administration in DEN‐treated experimental mice markedly reduced the derivatives of reactive oxygen metabolites/biological antioxidant potential ratio, which is a serum marker of oxidative stress, while increasing the mRNA expression of the antioxidant enzymes superoxide dismutase 2 and glutathione peroxidase 1 in the liver and white adipose tissue. The serum levels of adiponectin increased after astaxanthin administration in these mice.ConclusionDietary astaxanthin prevented the development of liver tumorigenesis in obese mice by improving oxidative stress and ameliorating serum adiponectin level. Therefore, astaxanthin may be useful in the chemoprevention of liver tumorigenesis in obese individuals.