bluuebunny/crossref_metadata_2025_split huggingface dataset:
R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability
Authors: Chen Hsuan-Yu , Yu Sung-Liang , Ho Bing-Ching , Su Kang-Yi , Hsu Yi-Chiung , Chang Chi-Sheng , Li Yu-Cheng , Yang Shi-Yi , Hsu Pin-Yen , Ho Hao , Chang Ya-Hsuan , Chen Chih-Yi , Yang Hwai-I , Hsu Chung-Ping , Yang Tsung-Ying , Chen Kun-Chieh , Hsu Kuo-Hsuan , Tseng Jeng-Sen , Hsia Jiun-Yi , Chuang Cheng-Yen , Yuan Shinsheng , Lee Mei-Hsuan , Liu Chia-Hsin , Wu Guan-I , Hsiung Chao A. , Chen Yuh-Min , Wang Chih-Liang , Huang Ming-Shyan , Yu Chong-Jen , Chen Kuan-Yu , Tsai Ying-Huang , Su Wu-Chou , Chen Huei-Wen , Chen Jeremy J.W. , Chen Chien-Jen , Chang Gee-Chen , Yang Pan-Chyr , Li Ker-Chau 
Published: June 2015

Purpose Adenocarcinoma is the most dominant type of lung cancer in never-smoker patients. The risk alleles from genome-wide association studies have small odds ratios and unclear biologic roles. Here we have taken an approach featuring suitable medical actionability to identify alleles with low population frequency but high disease-causing potential. Patients and Methods Whole-genome sequencing was performed for a family with an unusually high density of lung adenocarcinoma with available DNA from the affected mother, four affected daughters, and one nonaffected son. Candidate risk alleles were confirmed by matrix-assisted laser desorption ionization time of flight mass spectroscopy. Validation was conducted in an external cohort of 1,135 participants without cancer and 1,312 patients with lung adenocarcinoma. Family follow-ups were performed by genotyping the relatives of the original proband and the relatives of the identified risk-allele carriers. Low-dose computed tomography scans of the chest were evaluated for lung abnormalities. Results YAP1 R331W missense mutation from the original family was identified and validated in the external controls and the cohort with lung adenocarcinoma. The YAP1 mutant-allele carrier frequency was 1.1% in patients with lung adenocarcinoma compared with 0.18% in controls (P = .0095), yielding an odds ratio (adjusted for age, sex, and smoking status) of 5.9. Among the relatives, YAP1-mutant carriers have overwhelmingly higher frequencies of developing lung adenocarcinoma or ground-glass opacity lung lesions than those who do not carry the mutation (10:0 v 1:7; P < .001). YAP1 mutation was shown to increase the colony formation ability and invasion potential of lung cancer cells. Conclusion These results implicated YAP1 R331W as an allele predisposed for lung adenocarcinoma with high familial penetrance. Low-dose computed tomography scans may be recommended to this subpopulation, which is at high risk for lung cancer, for personalized prevention and health management.
Myśl społeczna Zygmunta Baumana przed Marcem 1968: Od "mechanistycznej" o "aktywistycznej" wersji marksizmu
Authors: Brzezińki Dariusz 
Published: June 2015

The Social Thought of Zygmunt Bauman before March 1968: from the “Mechanistic” to the “Activistic” Version of Marxism
In the middle of the 1960s Bauman indicated two ways of interpretation of Karl Marx’ thought. The former he defined as “mechanistic”, the latter as “activistic”. He stated that the representatives of the mechanistic one emphasise the concept of historical necessity. They aim at exploring the direction of social processes and making people conscious of it. The representatives of the activistic version of Marxism concentrate on the role of human praxis. They emphasise the role of individual initiative in making history. The typology made by Bauman is useful not only in making research of Marxist thought, but in outlining the evolution of his own very early sociology as well. When he began his academic career in Poland he had strongly believed in the laws of history and had anticipated the quick “leap to the Kingdom of Freedom”. However, in the course of time his view on this subject had changed. Short before his expulsion from Poland he accepted the “activistic” interpretation of Marxism, based on the indeterministic vision of society. In this paper I present this evolution and indicate the social and political factors that contributed to it. Another aim of this article is to evaluate the very early Marxist thought of Zygmunt Bauman.
Alpha Decay Half Lives of 148Gd 150Gd and 146Sm
Authors: Friedman A. M. , Milsted J. , Metta D. , Henderson D. , Lerner J. , Harkness A. L. , Rok Op D. J. 
Published: June 2015

Summary
The alpha half lives and energies of 148Gd, 150Gd, and 148Sm are found to be:

148Gd 97.5 ± 6.5 yrs. 3.17 ± .02 MeV

150Gd 1.78 ± (.08) • 106 yrs. 2.7 ± .10 MeV

148Sm 1.026 ± (.048) • 108 yrs. 2.55 ± .03 MeV
The half life of 148Sm is long enough so that it might be as high as 10-15 of normal Sm.
Simulation in Pediatric Emergency Medicine Fellowships
Authors: Doughty Cara B. , Kessler David O. , Zuckerbraun Noel S. , Stone Kimberly P. , Reid Jennifer R. , Kennedy Christopher S. , Nypaver Michele M. , Auerbach Marc A. 
Published: June 2015

BACKGROUND AND OBJECTIVES:
Graduate medical education faces challenges as programs transition to the next accreditation system. Evidence supports the effectiveness of simulation for training and assessment. This study aims to describe the current use of simulation and barriers to its implementation in pediatric emergency medicine (PEM) fellowship programs.

METHODS:
A survey was developed by consensus methods and distributed to PEM program directors via an anonymous online survey.

RESULTS:
Sixty-nine (95%) fellowship programs responded. Simulation-based training is provided by 97% of PEM fellowship programs; the remainder plan to within 2 years. Thirty-seven percent incorporate &gt;20 simulation hours per year. Barriers include the following: lack of faculty time (49%) and faculty simulation experience (39%); limited support for learner attendance (35%); and lack of established curricula (32%). Of those with written simulation curricula, most focus on resuscitation (71%), procedures (63%), and teamwork/communication (38%). Thirty-seven percent use simulation to evaluate procedural competency and resuscitation management. PEM fellows use simulation to teach (77%) and have conducted simulation-based research (33%). Thirty percent participate in a fellows’ “boot camp”; however, finances (27%) and availability (15%) limit attendance. Programs receive simulation funding from hospitals (47%), academic institutions (22%), and PEM revenue (17%), with 22% reporting no direct simulation funding.

CONCLUSIONS:
PEM fellowships have rapidly integrated simulation into their curricula over the past 5 years. Current limitations primarily involve faculty and funding, with equipment and dedicated space less significant than previously reported. Shared curricula and assessment tools, increased faculty and financial support, and regionalization could ameliorate barriers to incorporating simulation into PEM fellowships.
Does the Preemptive Use of Oral Nonsteroidal Anti-inflammatory Drugs Reduce Postoperative Pain in Surgical Removal of Third Molars? A Meta-analysis of Randomized Clinical Trials
Authors: Costa Fábio Wildson Gurgel , Esses Diego Felipe Silveira , de Barros Silva Paulo Goberlânio , Carvalho Francisco Samuel Rodrigues , Sá Carlos Diego Lopes , Albuquerque Assis Filipe Medeiros , Bezerra Tácio Pinheiro , Ribeiro Thyciana Rodrigues , Fonteles Cristiane Sá Roriz , Soares Eduardo Costa Studart 
Published: June 2015

Abstract
The purpose of this study was to investigate the effectiveness of preemptive analgesia with nonsteroidal anti-inflammatory drugs (NSAIDs) in third-molar surgery. A PubMed literature search was conducted for articles restricted to the English language using the following terms (DeCS/MeSH) or combinations: analgesia, third molar, and preemptive. From a total of 704 articles, 6 (n = 420 subjects) were selected. All studies presented a low risk of bias (Cochrane criteria) but exhibited high heterogeneity of methods. Two studies were excluded from the meta-analysis because they did not have adequate numeric values (dichotomous data) for the calculations. Preemptive analgesia showed no significant benefit (n = 298, P = .2227, odds ratio: 2.30, 0.60–8.73) in reducing postoperative pain after removal of lower impacted third molars. However, there was a probable direct relationship between the effectiveness of NSAIDs in preemptive analgesia for removal of third molars and its selectivity for the cyclooxygenase-2 (COX-2). Preemptive analgesia did not have a significant effect in reducing postoperative pain after removal of lower impacted third molars. More homogeneous and well-delineated clinical studies are necessary to determine a possible association between NSAIDs' selectivity for COX-2 and treatment effectiveness.
Antiviral mode of action of <i>Lactobacillus plantarum</i> YML009 on Influenza virus H1N1
Authors: Rather Irfan Ahmad , Choi Kwang-Ho , Bajpai Vivek K. , Park Yong-Ha 
Published: June 2015

<p>The development of resistance against antiviral agents has augmented a threat to public health sector. Consequently there is an expanding demand for the development of unconventional antiviral agents that could efficiently replace the existent in-use drugs. The probiotic strains of lactic acid bacteria (LAB) have earned the status of being efficient, economical and safe “nutraceutical” in health care armamentarium. A total of 2272 LAB strains were screened against H1N1 virus. The isolate YML009 displayed a pronounced antiviral activity. Sequencing and biochemical assays identified the isolate as <em>Lactoballius plantarum</em> which, exhibited resistance to the damage caused by the acidic conditions such as gastric juice and 5% bile salt. The anti-H1N1 activity of the strain was confirmed by hemagglutination assay and was found to display enhanced efficacy in comparison to the commercially available antiviral drug. This is a primary report on anti-influenza activity of a bacterium<em> L. plantarum</em> YML009. </p><p> </p>
Does Electric Stimulation of the Vastus Medialis Muscle Influence Rehabilitation After Total Knee Replacement?
Authors: Avramidis Kyriakos , Karachalios Theofilos , Popotonasios Konstantinos , Sacorafas Dimitrios , Papathanasiades Athanasios A. , Malizos Konstantinos N. 
Published: June 2015

Patients with knee osteoarthritis present with reduced quadriceps muscle strength, which is partially responsible for impaired function and disability. Although total knee replacement (TKR) is an effective surgical procedure, residual muscle weakness is not usually addressed and may persist for years postoperatively. This article reports the results of a prospective, randomized, controlled trial evaluating the effect of electric muscle stimulation of the vastus medialis on the speed and effort of walking, quality of life, and knee performance in patients undergoing TKR.Seventy patients who underwent TKR were randomly divided into 2 groups. Patients in group A received electric muscle stimulation and standard physiotherapy for 6 weeks, while patients in group B received physiotherapy only. All patients were assessed with both subjective and objective clinical scales preoperatively and at 6, 12, and 52 weeks postoperatively. Patients in group A demonstrated a statistically significant increase in walking speed, Oxford Knee Score, and American Knee Society function score compared to those in group B at 6 weeks (P=.003, .001, and .001, respectively) and at 12 weeks (allP=.001). A statistically significant increase in the SF-36 physical component summary score was observed at 6, 12, and 52 weeks (allP=.001). Three patients found the sensation of the electrical stimulation uncomfortable and abandoned its use. No skin reactions and surgical site infections were observed. Electrical stimulation of the vastus medialis muscle in addition to conventional physiotherapy improves functional recovery and early rehabilitation after TKR.
Late Symptomatic Heterotopic Ossification of the Patellar Tendon After Medial Parapatellar Intramedullary Nailing of the Tibia
Authors: Howell Ronald Damani , Park Ji Hae , Egol Kenneth A. 
Published: June 2015

This article describes a case of a 21-year old man who presented with symptomatic heterotopic ossification of the patellar tendon 3.5 years postinjury. The patient sustained an open tibia fracture during a fall and was treated by reamed intramedullary nailing through a medial paratendinous approach. Radiographic evidence of heterotopic ossification in the patellar tendon was first noted at the 4-week follow-up. He presented at 3.5 years postinjury with new-onset anterior knee pain and reported no interval trauma to the knee. Radiographs revealed a well-circumscribed area of calcification within the patellar tendon, which was excised within 2 weeks. On excision, the patient’s symptoms had resolved.
This case is unique because the patellar tendon was not violated at initial or subsequent surgeries, and because of the delayed presentation of heterotopic bone within the patellar tendon. To date, there have been only 3 reported cases of heterotopic ossification of the patellar tendon after intramedullary nailing of the tibia. We present a case of late symptomatic heterotopic ossification of the patellar tendon after medial paratendinous intramedullary nailing of an open tibia shaft fracture.
Repeatability Data and Agreement of Keratometry With the VERION System Compared to the IOLMaster
Authors: Nemeth Gabor , Szalai Eszter , Hassan Ziad , Lipecz Agnes , Berta Andras , Modis Laszlo 
Published: June 2015

PURPOSE:
To analyze the repeatability of keratometric and white-to-white (WTW) distance measurements with the VERION Measurement Module (Alcon Laboratories, Inc., Fort Worth, TX) and to compare the measured data to the results of the IOLMaster (Carl Zeiss Meditec, Jena, Germany).

METHODS:

Three images were captured with the VERION and the flattest and steepest keratometric data, the astigmatism axis, and the WTW distance were recorded. Subsequently, the axial length, the keratometric data with axis, and the WTW distance were measured with an IOLMaster. The repeatability data of the keratometric value of the VERION System, converted to cross cylinder J
0
and J
45
vector components, were analyzed. The agreement data for keratometry obtained by the VERION System and the differences regarding keratometric data and WTW distance compared to IOLMaster were calculated.

RESULTS:

The measurements were conducted in 50 eyes of 50 healthy volunteers (median age: 50.32 years, range: 19.34 to 85.3 years). The flattest and the steepest keratometric data, the diopter of astigmatism, the J
0
and J
45
vector components, and WTW distance did not differ significantly between devices (
P
> .05). Intraclass correlation coefficients (range: 0.863 to 0.994) and Cronbach’s alpha values (range: 0.950 to 0.998) were high for all parameters measured by the VERION System.

CONCLUSIONS:
The VERION System has high repeatability and agreement with the IOLMaster, making it suitable as an alternative tool in clinical practice.

[
J Refract Surg.
2015;31(5):333–337.]
Valorisation de déchets de caoutchouc dans les matériaux de construction : cas d’un composite cimentaire cellulaire
Authors: Benazzouk A. , Douzane O. , Queneudec M. 
Published: June 2015

In this work, the idea is to use rubber waste particles as a raw material, to develop a new lightweight construction materials. The objective of the research reported in this paper is to investigate the physico-mechanical properties of Aerated Cement-Rubber Composites (ACRC), based on rubber particles. The volume content ratio of the rubber particles ranged from 0% to 50%. The aerated composite was produced using a new type of proteinic air-entraining agent, in accordance with a specific aerating process derived in the laboratory. The aerated composite was produced to be used in cellular concrete applications. Results from tests performed on fresh aerated composites have demonstrated many attractive properties, such as improved workability and a high stability of air bubbles within the matrix. A study conducted on hardened composite properties has indicated a significant reduction in sample unit weight, thereby resulting in a level of compressive strength. The composite satisfies the basic requirement of construction materials, and could be used for insulated load-bearing wall this study has also highlighted the effect of the proteinic air-entraining agent on the cementrubber interaction system, as regards the composite’s compressive strength. However, an examination of the composite’s water capillary absorption reveals that the addition of rubber particles tends to restrict water propagation and reduce water absorption; sorptivity values decrease with increasing rubber particles content.
Cette étude concerne l’évaluation des propriétés du composite cellulaire ciment-caoutchouc, élaboré à base de poussières de caoutchouc pour des teneurs allant de 0 à 50 %. L’allégement a été effectué suivant un procédé d’allégement par moussage protéinique, mis au point au laboratoire, en vue de l’utilisation du composite dans le domaine d’application des bétons cellulaires. L’étude du composite à l’état frais a montré une amélioration de la maniabilité, avec une bonne stabilité des bulles d’air dans la matrice. L’étude du composite à l’état durci a montré une nette réduction de la masse volumique, avec des propriétés mécaniques compatibles avec l’utilisation en isolant porteur. L’effet de l’agent entraîneur d’air protéinique sur les liaisons matrice/caoutchouc dans la résistance du composite a été mis en évidence. L’étude de l’absorption par capillarité du composite a montré que l’ajout de poussières de caoutchouc réduit la sensibilité à l’eau du composite.
Étude de la répétabilité de la réponse à un test de lixiviation sur du mâchefer d'UIOM
Authors: Pascual Christophe , Boos Brigitte 
Published: June 2015

For this study, a great number of leaching test has been done on the same waste to energy bottom ash. The influence of sampling on the results is very important. Despite many precautions, the whole repetitiveness (sampling, leachting test, analysis), is not enough regarding some chemical parameters, if standard Afnor X-31 210 is strictly applied (4 mm crushing).
Pour cette étude, un grand nombre de tests de lixiviation a été réalisé sur un même mâchefer d'incinération d'ordures ménagères. La qualité de l'échantillonnage est essentielle. Malgré de grandes précautions, la répétabilité de la totalité de l'opération (échantillonnage, test de lixiviation, analyse) n'est pas suffisante vis-à-vis de certains paramètres chimiques quand on applique strictement la norme Afnor X-31 210 (concassage à 4 mm).
Herstelgericht reclasseren: De contextuele benadering als kader voor herstelgericht werken
Authors: Openneer Ewout 
Published: June 2015

The contextual approach to therapy as a framework for restorative practices within probation work
Restorative Justice could have a more extensive implementation within criminal justice if there was more restorative practice within probation work. This may also lead to more restorative mediation. This article is based on practice-based research on what is known about restorative practices within probation and how contextual therapy, developed by the Hungarian-American psychiatrist Ivan Böszörményi-Nagy, can contribute to this. The main conclusion is that contextual therapy can offer a currently non-existent framework that is needed to be able to work with restorative practices within probation. This article describes how contextual approaches can be useful for probation officers.
La tourbière relocalisée de l’île Notre-Dame : un exemple de mesure de compensation en avance sur son époque
Authors: Pellerin Stéphanie , Arricastres Vincent , Long-Raymond Lauriane , Lavoie Martin 
Published: June 2015

La tourbière de l’île Notre-Dame a été créée il y a 35 ans dans le cadre des « Floralies Internationales de Montréal – 1980 » à partir de blocs de tourbe de surface prélevés dans une tourbière de la région de la baie James vouée à l’ennoiement. Nous avons étudié les changements survenus dans la composition floristique de cette tourbière sous les angles spécifique (les espèces) et fonctionnel (traits fonctionnels). Entre 1979 et 2014, une baisse de 48 % de la richesse globale a été observée, ainsi qu’une augmentation importante de la représentation des espèces exotiques, généralistes et méridionales. Seules 5 des 56 espèces trouvées originalement sont encore présentes aujourd’hui sur la tourbière. Des changements importants ont aussi été notés entre les traits fonctionnels de la flore de 1979 et ceux de la flore de 2014. Ainsi, les besoins moyens en acidité, en humidité et en matière organique dans le substrat ainsi qu’en lumière ont significativement diminué. En revanche, les besoins moyens en nutriments dans le sol ont significativement augmenté. Ces changements indiquent que le site évolue vers un environnement plus sec et plus riche, de moins en moins caractéristique d’une tourbière. En conclusion, nous présentons quelques suggestions pour accroître la réussite des projets de création de milieux humides.
Évolution du statut nutritif des sapinières à la Forêt Montmorency entre 1967 et 2011
Authors: Ouimet Rock , Moore Jean-David , Duchesne Louis 
Published: June 2015

Cette étude avait pour objectif d’évaluer l’évolution du statut nutritif des sapinières de la Forêt Montmorency en se basant sur des analyses foliaires faites en 1967, 1988 et en 2011. La composition minérale des aiguilles du sapin baumier (Abies balsamea) a grandement fluctué au cours de ces 45 ans. Entre 1967 et 2011, nous avons observé une baisse de 5,7 % des teneurs en azote dans le feuillage, de 13,5 % des teneurs en potassium (aiguilles âgées de 1 an) et de 18 % des teneurs en magnésium (aiguilles âgées de 2 et de 3 ans). En 1988, les teneurs étaient en général beaucoup plus faibles que celles observées lors des 2 autres campagnes d’échantillonnage. Cette baisse peut s’expliquer en partie par le choix des peuplements visités, la hausse des précipitations acides depuis le début des années 1970, les épidémies d’insectes ravageurs et les extrêmes climatiques. Les teneurs en potassium du feuillage âgé de 1 an demeurent plus faibles que celles rapportées ailleurs dans la littérature pour le sapin baumier. La baisse des teneurs en potassium et en magnésium de 1967 à 2011 laisse croire à une perte de fertilité des sols dans cette région au cours des 45 dernières années.
Enhancing the Acyltransferase Activity of Candida antarctica Lipase A by Rational Design
Authors: Müller Janett , Sowa Miriam A. , Fredrich Birte , Brundiek Henrike , Bornscheuer Uwe T. 
Published: June 2015

AbstractA few lipases, such as Candida antarctica lipase A (CAL‐A), are known to possess acyltransferase activity. This enables the enzyme to synthesize fatty acid esters from natural oils and alcohols even in the presence of bulk water. Unfortunately, fatty acids are still formed in these reactions as undesired side‐products. To reduce the amount of fatty acids, several CAL‐A variants were rationally designed based on its crystal structure. These variants were expressed in Escherichia coli and Pichia pastoris, purified, and their acyltransferase/hydrolase activities were investigated by various biocatalytic approaches. Among the investigated variants, mutant Asp122Leu showed a significant decrease in the hydrolytic activity, thus reducing the side‐product yield during acylation. As desired, this variant retained wild‐type process‐relevant features like pH profile and thermostability.