bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations
Authors: Beltrand Jacques , Elie Caroline , Busiah Kanetee , Fournier Emmanuel , Boddaert Nathalie , Bahi-Buisson Nadia , Vera Miriam , Bui-Quoc Emmanuel , Ingster-Moati Isabelle , Berdugo Marianne , Simon Albane , Gozalo Claire , Djerada Zoubir , Flechtner Isabelle , Treluyer Jean-Marc , Scharfmann Raphael , Cavé Helene , Vaivre-Douret Laurence , Polak Michel ,   on behalf of the GlidKir Study Group
Published: October 2015

OBJECTIVE
Neonatal diabetes secondary to mutations in potassium-channel subunits is a rare disease but constitutes a paradigm for personalized genetics-based medicine, as replacing the historical treatment with insulin injections with oral sulfonylurea (SU) therapy has been proven beneficial. SU receptors are widely expressed in the brain, and we therefore evaluated potential effects of SU on neurodevelopmental parameters, which are known to be unresponsive to insulin.

RESEARCH DESIGN AND METHODS
We conducted a prospective single-center study. Nineteen patients (15 boys aged 0.1–18.5 years) were switched from insulin to SU therapy. MRI was performed at baseline. Before and 6 or 12 months after the switch, patients underwent quantitative neurological and developmental assessments and electrophysiological nerve and muscle testing.

RESULTS
At baseline, hypotonia, deficiencies in gesture conception or realization, and attention disorders were common. SU improved HbA1c levels (median change −1.55% [range −3.8 to 0.1]; P &lt; 0.0001), intelligence scores, hypotonia (in 12 of 15 patients), visual attention deficits (in 10 of 13 patients), gross and fine motor skills (in all patients younger than 4 years old), and gesture conception and realization (in 5 of 8 older patients). Electrophysiological muscle and nerve tests were normal. Cerebral MRI at baseline showed lesions in 12 patients, suggesting that the impairments were central in origin.

CONCLUSIONS
SU therapy in neonatal diabetes secondary to mutations in potassium-channel subunits produces measurable improvements in neuropsychomotor impairments, which are greater in younger patients. An early genetic diagnosis should always be made, allowing for a rapid switch to SU.
ISOLATION OF QUERCETIN FROM FLOWER PETALS, ESTIMATION OF TOTAL PHENOLIC, TOTAL FLAVONOID AND ANTIOXIDANT ACTIVITY OF THE DIFFERENT PARTS OF RHODODENDRON ARBOREUM SMITH
Authors: Bhandari Laxman , Rajbhandari Meena 
Published: October 2015

The flowers of Rhododendron arboreum Smith is a source of polyphenolic compounds. A flavonol, quercetin, was isolated from ethyl acetate fraction of the methanol extract of flower petals of R. arboreum by repeated Sephadex LH-20 column chromatography. Isolated quercetin was characterized by comparing melting point, Rf values, UV and IR spectra with authentic quercetin. The isolated quercetin was used as a standard for the estimation of total flavonoids. Total phenolic and total flavonoid content in different parts of R. arboreum was carried out spectrophotometrically using Folin-Ciocalteu reagent and Aluminium chloride reagent respectively. Gallic acid and quercetin were used as standard for the construction of calibration curve of phenolic and flavonoid respectively. The results showed that the highest total phenolic content was detected in the 70% acetone extract of the flowers (600 mg GAE/g extract) and petals (600 mg GAE/g extract) and the lowest amount was detected in methanol extract of stem (188 mg GAE/g extract). Similarly, the highest total flavonoid was detected in the 70% acetone extract of the twigs (170 mg QE/g extract) and the lowest amount was detected in the methanol extract of stem (45 mg QE/g extract). The antioxidant activity of the methanol extracts obtained from different parts of R. arboreum was determined by 2, 2- diphenyl-1-picryl hydrazyl (DPPH) assay and the radical scavenging activity (IC50) was calculated. The highest free radical scavenging effect was observed in leaves with IC50=8.34 ?g/ml and lowest was observed in stem with IC50=67.83 ?g/ml. The IC50 values, total phenolic and total flavonoid content (correlation coefficient R2= 0.923 for phenolic, R2= 0.965 for flavonoid) were correlated which showed strong correlation indicating that the major components responsible for antioxidant activity is phenolics. The highest the phenolic content, the lowest the IC50 value observed. The result indicated that R. arboreum is a rich source of high value polyphenols as natural antioxidant to use in preventive medicine as well as in food and pharmaceutical industry.Scientific World, Vol. 12, No. 12, September 2014, page 34-40
Le procès du magistrat d'Orchies après l'occupation autrichienne de 1793-1794
Authors: Robinet René 
Published: October 2015

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Gedurende de Oostenrijkse bezetting die 14 maand duurde wordt Orchies bestuurd door een nieuw korps van magistraten benoemd door de « jointe » van Valenciennes op voor- dracht van de vroegere landsheren. Wat is hun lot na de herovering door de légers van de Republiek op 15 juli 1794. Na twee processen in november 1794 en maart 1795 waarin zowel gunstige als ongunstige argumenten naar voor werden gebracht, worden de 16 bes- chuldigde magistraten van Orchies vrijgesproken.
Le Journal des connaissances utiles de Girardin (1831-1836...) ou la première réussite de la presse à bon marché
Authors: Albert Pierre 
Published: October 2015

De «Journal des connaissances utiles » werd einde 1831 opgericht door Girardin en kende bliksemsnel sukses : 125 000 abonnées midden 1833, dan een snelle afgang : nog 60 000 in 1834 en 20 000 in 1835. De studie van dit blad werpt licht op die uitgaven (boe- ken en tijdschriften) met een vulgariserend karakter (onderwijs en cultuur) die na 1830 zoveel sukses kenden. Het is gedccltelijk een voorbeeld van de bloei van geïllustreerde volksbladen. Men moet in dit verband ook het belang van de Engelse invloed nagaan : was Girardin de Franse Brougham ? De studie biedt ook een analyse van de commerciële en journalistieke methoden van Girardin die toen op het punt stond zijn dagblad te lanceren, tegen een jaarlijkse abonnementsprijs van 40 francs.
De « Journal des connaissances utiles » heeft aan het licht gebracht dat er een énorme weet- en leesgierigheid bestond in de « midden » -klassen en dat zal in de volgende jaren impulsen geven voor een verdere uitbreiding van de markt voor de pers.
Les pouvoirs locaux et les débuts de la formation professionnelle dans le Nord sous la Troisième République (1880-1914)
Authors: Vandenbussche Robert 
Published: October 2015

In a region like the North were industrial growth was fast, one could have expected a rapid progress in the training of skilled workers. However, begore 1900, imitiatives were scarce, except for the creation of the Ecole Professionnelle in Armentières in 1887 and the municipal courses organized by some towns founded in the North : the commercial and industrial Ecole Pratique in Fourmies and the industrial Ecole Pratique in Lille.
After 1900 the initiatives were multiplied thanks to the common efforts of two men : Gustave Dron, member of Parliament and mayor of Tourcoing, and Edouard Labbé, general inspector of technical education. Those two men brought the problems out and favoured new foundations that's how the chief industrial towns, according to the 1892 law were provided with technical schools : Tourcoing, Roubaix, Denain, Maubeuge, Valenciennes, Douai, Dunkerque.
This development of technical education was not simple. It raised financial problems that town councils had to solve. But it also pointed to fundamental problems : who should technical training responsibilities fall on ? Firms or public authorities ? Opposed interest hampered the efforts made to structure technical training. But this couldn't prevent the North from becoming the department where technical education started awaking interest.
Un conflit économique entre Lille et Roubaix (1553)
Authors: Baelde M. 
Published: October 2015

Il est intéressant de noter que les temps de crise pendant l'Ancien Régime provoquent beaucoup de conflits entre les grandes villes d'une part et les petites villes et les régions rurales d'autre part.
Un bel exemple dans ce sens là constitue le long conflit économique entre Lille et Roubaix ; un procès est introduit en 1553 devant le Conseil Privé à Bruxelles concernant les possibilités économiques de Roubaix, contestés par Lille. Les arguments de Roubaix contiennent entre autres que « audit Roubaix n'y a passaige, rivière n'y autre moyen de gaigner que au filler et faire ouvraiges de tripes de velours et bourgetries ». Malgré l'opposition de Lille, on constate que le Conseil Privé arrive à la conclusion que « lesdits manans dudit Roubaix pourraient faire et exercer de grosses estoffes ». On peut donc conclure qu'un compromis raisonnable fut atteint en 1553.
Ploidy and domestication are associated with genome size variation in Palms
Authors: Gunn Bee F. , Baudouin Luc , Beulé Thierry , Ilbert Pascal , Duperray Christophe , Crisp Michael , Issali Auguste , Konan Jean‐Louis , Rival Alain 
Published: October 2015

PREMISE OF THE STUDY:The genome size of a species (C‐value) is associated with growth, development and adaptation to environmental changes. Angiosperm C‐values range 1200‐fold and frequently vary within species, although little is known about the impacts of domestication on genome size. Genome size variation among related species of palms is of evolutionary significance because changes characterize clades and may be associated with polyploidy, transposon amplifications, deletions, or rearrangements. Further knowledge of genome size will provide crucial information needed for planning of whole genome sequencing and accurate annotations. We studied the genome size of Cocos nucifera and its variation among cultivars, and compared it to values for related palms from the Attaleinae subtribe.METHODS:Flow cytometric analysis of isolated nuclei from young palm leaves was used to estimate genome sizes of 23 coconut cultivars (Talls, Dwarfs, and hybrids) worldwide and 17 Cocoseae species. Ancestral genome size was reconstructed on a maximum likelihood phylogeny of Attaleinae from seven WRKY loci.KEY RESULTS:The coconut genome is large—averaging 5.966 pg—and shows intraspecific variation associated with domestication. Variation among Tall coconuts was significantly greater than among Dwarfs. Attaleinae genomes showed moderate size variation across genera, except polyploids Jubaeopsis caffra, Voanioala gerardii, Beccariophoenix alfredii, and Allagoptera caudescens, which had larger genomes.CONCLUSIONS:Our results contribute to the understanding of the relationship between domestication and genome size in long‐lived tree crops and provide a basis for whole‐genome sequencing of the coconut and other domesticated plants. Polyploidy evolved independently in two clades within Attaleinae.
The Safety and Efficacy of Ledipasvir/Sofosbuvir for the Treatment of a Nosocomial Outbreak of HCV in Patients with Significant Cardiovascular Disease
Authors: Simon Tracey G , Kim Arthur Y , Stamm Luisa M , Liu Lin , Mo Hongmei , Doehle Brian , Pang Phillip S , Brainard Diana M , McHutchison John G , Gustafson Jenna , Lauer Georg M , Chung Raymond T 
Published: October 2015

Background There is an unmet need for interferon-and ribavirin-free treatment for chronic HCV infection in patients with comorbidities including cardiovascular disease (CVD). The aim of this study was to evaluate the rates of sustained virological response (SVR) and adverse events in a cohort of patients with nosocomially acquired HCV genotype-1b following 12 weeks of therapy with fixed-dose combination (FDC) ledipasvir/ sofosbuvir (LDV/SOF). Methods This is a prospective, single-centre, open-label study of five non-cirrhotic patients with HCV genotype-1b and significant comorbid CVD, conducted at the Massachusetts General Hospital. All patients were prescribed an FDC tablet (LDV 90 mg/SOF 400 mg) once daily for 12 weeks. Serial measurements of safety parameters, virology, host immune correlates and adherence were performed. The primary outcome was the proportion of patients with SVR (plasma HCV RNA level <25 IU/ml), 12 weeks after treatment completion (SVR12). Results All five patients (100%) achieved SVR12, with no episodes of on- or post-treatment relapse. The most commonly reported adverse events were gastrointestinal illness and upper respiratory viral-type illness. There were no serious adverse events or discontinuations of medication attributable to the study drug. Deep sequencing analysis revealed no baseline NS3, NS5A or NS5B resistance-associated variants. Conclusions In this open-label, uncontrolled, pilot study enrolling patients with HCV genotype-1b and significant CVD, administration of a fixed-dose, oral combination of LDV and SOF for 12 weeks was associated with high rates of SVR and minimal adverse events. Larger prospective studies that also include patients with cirrhosis and prior treatment non-responders are necessary.
L’Agenda 2063 et l’application des principes de bonne gouvernance : le cas de la Côte d’Ivoire
Authors: Niamien N’Goran Emmanuel 
Published: October 2015

L’unité, la prospérité et la sécurité promues par l’Agenda 2063 pour l’Afrique ne pourront se réaliser que par une mobilisation de tous. Celle-ci passe par l’application des principes de « bonne gouvernance ». En Côte d’Ivoire, un certain nombre de mesures et d’institutions ont été mises en place pour concrétiser ces principes et mettre fin au climat d’insécurité nationale. Le Président Alassane Ouattara s’attelle fermement à restaurer l’autorité de l’État et assainir le pays de la corruption. L’amélioration des services publics et l’efficacité de l’Administration seront indispensables – avec la « bonne gouvernance » – au développement de la Côte d’Ivoire.
Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells
Authors: Jones Derek D. , Wilmore Joel R. , Allman David 
Published: October 2015

Abstract
Despite their critical role in long-term immunity, the life span of individual memory B cells remains poorly defined. Using a tetracycline-regulated pulse-chase system, we measured population turnover rates and individual t1/2 of pre-established Ag-induced Ig class-switched and IgM-positive memory B cells over 402 d. Our results indicate that, once established, both IgG-positive and less frequent IgM-positive memory populations are exceptionally stable, with little evidence of attrition or cellular turnover. Indeed, the vast majority of cells in both pools exhibited t1/2 that appear to exceed the life span of the mouse, contrasting dramatically with mature naive B cells. These results indicate that recall Ab responses are mediated by stable pools of extremely long-lived cells, and suggest that Ag-experienced B cells employ remarkably efficient survival mechanisms.
Ability of the National Board for Certification in Occupational Therapy Practice Test to Estimate the Probability of First-Time Pass Status on the National Certification Exam
Authors: Avi-Itzhak Tamara 
Published: October 2015

Abstract
OBJECTIVE. To estimate the ability of the National Board for Certification in Occupational Therapy (NBCOT) practice test to predict first-time pass status on the NBCOT Occupational Therapist Registered exam.
METHOD. Performance ratios for the four NBCOT practice test domains were used to develop a logistic regression model for estimating the probability of first-time pass status on the NBCOT exam.
RESULTS. Of 65 students who graduated during academic years 2010–2013, 41 (63%) attained first-time pass status. The logistic regression model was a good fit. The variance explained ranged from 22% to 29%. The odds of first-time no-pass status were associated with performance ratios on Domains 1 and 2 but not Domains 3 and 4.
CONCLUSION. To maximize the probability of students’ attaining first-time pass status, faculty should consider ways to increase their exposure to the tasks and skills required for implementation of intervention plans (Domains 3 and 4).
The Kundum Festival in Ghana
Authors: Etikpah Samuel Edukubile 
Published: October 2015

Abstract
During the Kundum festival in Ghana, people ritually express their wishes for productive farming and fishing seasons, social progress, spiritual protection, and a healthy natural environment, bringing into play the nonhumans expected to uphold or oppose these objectives. This article contributes to an improved analysis of the perspectives of intersubjectivity, relationship, and community in African rituals by examining the interaction between nonhumans and humans in the Kundum festival. It analyzes some of the transitional rites that constitute Kundum. These rites are less the markers of life-cycle or seasonal transitions than the very cultural resources by which transitions are put into effect in creating hope for the fertility of farmlands and rivers. They are linked to the creation of a purified food production season, to healing, to the roles assigned to nonhumans in the initiation of the festival, and to a configuration of relationships in a shared world.
Heritage Collection of Traditional Pottery in Ayios Demetrios, Cyprus
Authors: London Gloria A. , Dometios Father 
Published: October 2015

ABSTRACTA collaborative effort to create a heritage collection of traditional Cypriot handmade pottery, and the tools used to make and decorate them in Ayios Demetrios (Marathassa), brings together 135 artifacts donated by villagers. They are descendants of the men and women who made and used the artifacts. The collection is part of the living memory of the donors who recall helping their parents by preparing clay and carrying out other chores related to production. Donors have supplied the information they know about pot makers, pot names, usage, and age. Preliminary analysis of 60 decorated pots, provides data relevant to archaeologists interested in learning how long styles and manufacturing practices can persist in a rural setting.
Hygiene: basic care that promotes comfort in critically ill patients
Authors: Carvajal Carrascal Gloria , Montenegro Ramírez Juan David 
Published: October 2015

<br />Los pacientes hospitalizados en entornos críticos requieren la provisión de cuidados de enfermería para satisfacer sus necesidades básicas. Las intervenciones encaminadas a satisfacer las necesidades de higiene son cuidados de enfermería, inherentes al rol profesional y que actualmente se omiten o delegan por considerarlas de poco valor, sin tener en cuenta que constituyen indicadores de resultado en los pacientes y de la calidad de atención en las unidades de cuidado crítico. <br /><br />Objetivo: Analizar la importancia social, disciplinar y teórica de la higiene como un cuidado básico de enfermería requerido por los pacientes críticos y su relación con la comodidad a la luz de la teoría propuesta por Kolcaba.<br /><br />Método: Revisión de la literatura y selección de artículos en las bases de datos ISI -Web of Knowledge, Scopus, Science Direct, Proquest, Ebsco, Medline, Ovid, Scielo y de otras fuentes como documentos no publicados y páginas web. La revisión incluyó 3 estudios cualitativos, 27 cuantitativos, 1 estudio mixto, 40 piezas documentales y 4 editoriales publicados por profesionales de enfermería y otras áreas de la salud. <br /><br />Resultados: Los resultados se organizaron en 4 categorías así, cuidados básicos de enfermería en entornos críticos, higiene como cuidado básico para los pacientes críticos, higiene y comodidad y necesidades de investigación.<br />Importancia clínica: Es indispensable que el profesional de enfermería asegure la satisfacción de las necesidades de higiene de los pacientes, así se proporciona seguridad, comodidad y bienestar. Durante la provisión de los cuidados de enfermería se presenta una oportunidad para que el profesional de enfermería se comunique con el paciente, evalúe el estado físico y psicológico, identifique posibles ansiedades y temores, planifique los cuidados y brinde una atención individualizada<br /><br />
Poétique du paysage dans L’Anté-peuple et La Vie et demie de Sony Labou Tansi
Authors: Gahungu Céline 
Published: October 2015

La forêt tropicale et le fleuve Congo ont façonné profondément la géographie mentale de Sony Labou Tansi. Fasciné par l’expérience des limites naturelles que constituent la furie des cataractes et les lacis de la végétation, il s’est désigné comme un « homme de la forêt » dont l’écriture tente de capter la puissance de ces sites naturels. Loin de donner lieu à d’amples tableaux descriptifs, La Vie et demie et L’Anté-peuple proposent des fragments paysagers élaborés sur un mode suggestif, où tous les sens entrent en jeu. Cette construction discursive dévoile les rouages d’une machine romanesque qui les utilise comme de véritables acteurs. Structurant la fiction, la géographie est modelée pour épouser l’imaginaire de l’auteur. Comment Sony Labou Tansi construit-il ces paysages ? En quoi ces modes de construction constituent-ils une voie de recherche pour appréhender les complexités de son écriture ?
Conception d’outils de mesure de l’offre active de services sociaux et de santé en français en contexte minoritaire
Authors: Savard Jacinthe , Casimiro Lynn , Bouchard Pier , Benoît Josée , Drolet Marie , Dubouloz Claire-Jehanne 
Published: October 2015

Dans les communautés francophones en situation minoritaire, le besoin d’une offre active des services en français, plutôt que d’un service qui suit la demande, est de plus en plus reconnu. Les professionnels en santé et en service social doivent être formés à cette approche et les résultats devront être évalués. Cet article décrit le processus de création et de validation de contenu (recension d’écrits, consultations d’experts, sondage Delphi pancanadien) de deux questionnaires portant sur les comportements caractéristiques de l’offre active de services sociaux et de santé en français : le premier mesurant les comportements individuels d’offre active des intervenants et le deuxième mesurant la perception de ces derniers du soutien organisationnel à l’offre active.
Bilan de santé : une analyse descriptive de l’état de la recherche sur la santé et les communautés francophones en situation minoritaire
Authors: Vézina Sylvain 
Published: October 2015

Ce texte présente un bilan des activités de recherche soutenues par le Consortium national de formation en santé (CNFS), selon l’orientation des connaissances produites et des pistes d’action qui en résultent. Nous y abordons la question de la participation du milieu à la planification de la recherche, sa réalisation et la mise en pratique des résultats. L’étude a été réalisée selon deux méthodes : une analyse du contenu des documents produits et une série d’entrevues avec des chercheurs et des représentants du milieu. L’objectif consiste à fournir quelques indications sur les atouts et les défis du rapprochement entre chercheurs et communautés dans la perspective de la recherche participative.