bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and swelling properties of a pH‐ and temperature‐dual responsive hydrogel by inverse microemulsion polymerization
Authors: Wan Tao , Chen Qiaohe , Zhao Qihua , Huang Runqiu , Liao Ling , Xiong Jing , Tang Li 
Published: March 2015

ABSTRACTA novel pH‐ and temperature‐dual responsive hydrogel was synthesized by inverse microemulsion polymerization, using itonic acid (IA) as pH‐responsive monomer, N‐isopropylacrylamide (NPAM) as thermo‐responsive monomer and acrylamide (AM) as the nonionic hydrophilic monomer. Factors affecting water and salt absorption, as well as swellability of the dual responsive hydrogels, such as IA/NPAM mass ratio and crosslinker amount, were investigated. pH‐ and temperature‐sensitivity and dynamic viscoelasticity behaviors of the dual responsive hydrogels were also studied. The dual responsive responsive hydrogels showed suitable water and salt absorbency, remarkable pH‐, and temperature‐sensitivity, adjustable swellability and enhanced viscoelastic behaviors under high stress. Water absorbency and pH‐sensitivity increased while salt absorbency and temperature‐ sensitivity decreased with increasing IA/NIPAM mass ratio. Both water absorbency and salt absorbency increased first with crosslinker amount increased to 0.2 wt %, and then decreased with increasing crosslinker amount. Temperature‐induced shrinkage range of the dual responsive hydrogels was higher and broader than that of the conventional poly(N‐isopropylacrylamide) hydrogel. TEM indicated that the as‐synthesized hydrogel particles were regular and spherical‐like in shape and had the mean particle size of 49nm in the range of 30–78 nm. FTIR indicated the structure of the dual responsive hydrogels. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42139.
An improved incremental assignment model for parking variable message sign location problem
Authors: Ni Xun‐You , Sun Daniel (Jian) , Peng Zhong‐Ren 
Published: March 2015

SummaryOperators and planners of parking guidance and information system (PGIS) often encounter the difficulty when and how to provide parking information to drivers in peak hours. The aim of this study was to assign the parking demands onto the urban network, find the positions suitable to locate the parking variable message sign (parking VMS), and try to solve the problem when to provide parking information to drivers. Parking VMS, as the most common forms of the information display terminal of PGIS, becomes critical in designing PGIS. This paper started from analyzing the relationship between the location and the performances of parking VMS. If a parking VMS is placed right along the link approaching to the divarication intersection of the subsequent “shortest path” and the previous one, the travel time declines abruptly, and the guiding compliance ratio becomes superior. Then, the network‐based parking choice model for the parking VMS was proposed. Network modification and incremental assignment were used to find the divarication intersections caused by the changes of space availability. In addition, MATLAB software package (MathWorks, Inc., Natick, MA, USA) was adopted to calculate the entire process mentioned. The proposed model and the algorithm were applied to a numerical example, where the location of parking VMS was obtained. Copyright © 2015 John Wiley & Sons, Ltd.
The Wicked Character of Sustainable Supply Chain Management: Evidence from Sustainability Reports
Authors: Meckenstock Johann , Barbosa‐Póvoa Ana Paula , Carvalho Ana 
Published: March 2015

AbstractSupply chains are changing their business paradigm as they strive for sustainability and not just for increasing profits. Sustainability, however, is a concept that is open to interpretation since it is based on societal and organizational values. Little is known about what companies actually mean when referring to sustainability, and how this contrasts with the understanding at different echelons of the supply chain. Diverging interpretations and translations of sustainability among stakeholders, termed wicked problems, affect the progress of sustainable supply chain management. This paper aims to contribute to closing the gap between our common sense expectations and the actual evidence from sustainability reports of how sustainability evolves from abstract ideas to operational practices across the supply chain. To this end, this study employs a computer‐aided content analysis of 142 corporate sustainability reports across 12 industries. Building on the findings, and using the lens of wicked problems, this paper provides guidance to practitioners on how to develop strategies that are effective across the whole supply chain. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
Forest Certification and ISO 14001: Current State and Motivation in Forest Companies
Authors: Tuppura Anni , Toppinen Anne , Puumalainen Kaisu 
Published: March 2015

AbstractIn this study, we explore the current state of specific corporate responsibility practices in the global forest sector. We compare the motivations for the leading forest industry companies to invest in certification from the Forest Stewardship Council (FSC) and the Programme for the Endorsement of Forest Certification (PEFC), and in the ISO 14001 environmental management system. For the empirical investigation, we use quantitative survey data collected from 60 of the world's leading forestry companies. This study's empirical results indicate that incentives for adopting forest certification are more often external rather than internal, and more market driven than regulation driven, which would suggest the dominance of extrinsic motivation. The results also indicate that the adoption of ISO 14001 certification represents a reactive strategic approach, emphasizing customer satisfaction as a key motivation. Motivations differ depending on the firm's business sector and the geographical location of its headquarters. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
Do Women Leaders Promote Sustainability? Analyzing the Effect of Corporate Governance Composition on Environmental Performance
Authors: Glass Christy , Cook Alison , Ingersoll Alicia R. 
Published: March 2015

AbstractIn this study, we investigate the impact women leaders have on the corporate environmental strategies of organizations. Using a dataset of all Fortune 500 CEOs and boards of directors for a ten‐year period, we examine several aspects of gender in leadership on environmental strategy. Specifically, we test the impact of women CEOs, the proportion of women on the BOD, the number of interlinks women board members hold, and the interactive and cumulative effects of women CEOs and gender diverse boards. Findings suggest that firms characterized by gender diverse leadership teams are more effective than other firms at pursuing environmentally friendly strategies. This study contributes to research on corporate governance and environmental performance by showing how the gender composition of leaders affects corporate practice. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
Phase I trial of systemic intravenous infusion of interleukin‐13‐Pseudomonas exotoxin in patients with metastatic adrenocortical carcinoma
Authors: Liu‐Chittenden Yi , Jain Meenu , Kumar Parag , Patel Dhaval , Aufforth Rachel , Neychev Vladimir , Sadowski Samira , Gara Sudheer K. , Joshi Bharat H. , Cottle‐Delisle Candice , Merkel Roxanne , Yang Lily , Miettinen Markku , Puri Raj K. , Kebebew Electron 
Published: March 2015

AbstractAdrenocortical carcinoma (ACC) is a rare but lethal malignancy without effective current therapy for metastatic disease. IL‐13‐PE is a recombinant cytotoxin consisting of human interleukin‐13 (IL‐13) and a truncated form of Pseudomonas exotoxin A (PE). The main objectives of this Phase I dose‐escalation trial were to assess the maximum‐tolerated dose (MTD), safety, and pharmacokinetics (PK) of IL‐13‐PE in patients with metastatic ACC. Eligible patients had confirmed IL‐13 receptor alpha 2 (IL‐13Rα2) expressions in their tumors. IL‐13‐PE at dose of 1–2 μg/kg was administered intravenously (IV) on day 1, 3, and 5 in a 4‐week cycle. Six patients received 1 μg/kg and two patients received 2 μg/kg of IL‐13‐PE. Dose‐limiting toxicity was observed at 2 μg/kg, at which patients exhibited thrombocytopenia and renal insufficiency without requiring dialysis. PK analysis demonstrated that at MTD, the mean maximum serum concentration (Cmax) of IL‐13‐PE was 21.0 ng/mL, and the terminal half‐life of IL‐13‐PE was 30–39 min. Two (25%) of the eight patients had baseline neutralizing antibodies against PE. Three (75%) of the remaining four tested patients developed neutralizing antibodies against IL‐13‐PE within 14–28 days of initial treatment. Of the five patients treated at MTD and assessed for response, one patient had stable disease for 5.5 months before disease progression; the others progressed within 1–2 months. In conclusion, systemic IV administration of IL‐13‐PE is safe at 1 μg/kg. All tested patients developed high levels of neutralizing antibodies during IL‐13‐PE treatment. Use of strategies for immunodepletion before IL‐13‐PE treatment should be considered in future trials.
Extraordinary consumer experiences: Why immersion and transformation cause trouble
Authors: Lindberg Frank , Østergaard Per 
Published: March 2015

AbstractThis paper presents and discusses how consumers are transformed in and out of immersion during extraordinary, long‐lasting wilderness canoeing experiences. Based on a hermeneutic multi‐phase empirical approach, we show how extraordinary experiences can be dynamic, multifaceted, and emergent. The positive connotations of prior research are questioned as we find that consumers face various paradoxes and ambiguities throughout the various consumption phases. While a major part of research today focuses on the co‐creation efforts of consumers when they combine various on‐site resource of experiencescapes, our findings point to the importance of understanding consumer resources. The distinction held between the ordinary and the extraordinary does not hold within the present context, and we discuss how role conflicts may influence transformation and immersion during consumption of experiences.
Chemical Composition and Biological Activity of Abies alba and A. koreana Seed and Cone Essential Oils and Characterization of Their Seed Hydrolates
Authors: Wajs‐Bonikowska Anna , Sienkiewicz Monika , Stobiecka Agnieszka , Maciąg Agnieszka , Szoka Łukasz , Karna Ewa 
Published: March 2015

AbstractThe chemical composition, including the enantiomeric excess of the main terpenes, the antimicrobial and antiradical activities, as well as the cytotoxicity of Abies alba and A. koreana seed and cone essential oils were investigated. Additionally, their seed hydrolates were characterized. In the examined oils and hydrolates, a total of 174 compounds were identified, which comprised 95.6–99.9% of the volatiles. The essential oils were mainly composed of monoterpene hydrocarbons, whereas the composition of the hydrolates, differing from the seed oils of the corresponding fir species, consisted mainly of oxygenated derivatives of sesquiterpenes. The seed and cone essential oils of both firs exhibited DPPH‐radical‐scavenging properties and low antibacterial activity against the bacterial strains tested. Moreover, they evoked only low cytotoxicity towards normal fibroblasts and the two cancer cell lines MCF‐7 and MDA‐MBA‐231. At concentrations up to 50 μg/ml, all essential oils were safe in relation to normal fibroblasts. Although they induced cytotoxicity towards the cancer cells at concentrations slightly lower than those required for the inhibition of fibroblast proliferation, their influence on cancer cells was weak, with IC50 values similar to those observed towards normal fibroblasts.
Exploring the Protein Stability Landscape: Bacillus subtilis Lipase A as a Model for Detergent Tolerance
Authors: Fulton Alexander , Frauenkron‐Machedjou Victorine Josiane , Skoczinski Pia , Wilhelm Susanne , Zhu Leilei , Schwaneberg Ulrich , Jaeger Karl‐Erich 
Published: March 2015

AbstractA systematic study was conducted with Bacillus subtilis lipase A (BSLA) to determine the effect of every single amino acid substitution on detergent tolerance. BSLA is a minimal α/β‐hydrolase of 181 amino acids with a known crystal structure. It can be expressed in Escherichia coli and is biochemically well characterized. Site saturation mutagenesis resulted in a library of 3439 variants, each with a single amino acid exchange as confirmed by DNA sequencing. The library was tested against four detergents, namely SDS, CTAB, Tween 80, and sulfobetaine. Surface remodeling emerged as an effective engineering strategy to increase tolerance towards detergents. Amino acid residues that significantly affect the tolerance for each of the four detergents were identified. In summary, this systematic analysis provides an experimental dataset to help derive novel protein engineering strategies as well as to direct modeling efforts.
A very unusual complication of amniocentesis
Authors: Hayat Munawar , Hill Michael , Kelly David , Tubbs R. Shane , Loukas Marios 
Published: March 2015

Key Clinical MessageThe uses of amniocentesis are numerous, including determination of chromosomal abnormalities, lung maturity, and infections. A common complication of amniocentesis is loss of the pregnancy, but rare complications should be considered. The role of patient history and clinical observation of uncommon presentations are critical in the management of the patient.
Activity Enhancement upon the Incorporation of Titanium: Au@Ti–SiO2 Core–Shell Nanocatalysts for the CO Oxidation Reaction
Authors: Sunil Sekhar Anandakumari C. , Ziyad Kottavarithottil , Soni Yogita , Vinod Chathakudath P. 
Published: March 2015

AbstractThe encapsulation of gold nanoparticles 8–12 nm in size within a porous Ti–SiO2 shell to form a core–shell nanoarchitecture was investigated, and the catalytic activity of the resulting structure was probed. Detailed characterization of the synthesized materials shows that the core–shell morphology is lost beyond a certain amount of incorporated titanium, and results in normal gold‐supported Ti–SiO2. The material has a high surface area (913 m2 g−1) and high porosity, both of which make it an excellent choice for catalytic applications. With the optimum amount of incorporated Ti, the core–shell catalyst shows excellent room‐temperature CO oxidation activity over several cycles with retention of its morphology at higher temperatures.
Guanosine in a Single Stranded Region of Anticodon Stem–Loop tRNA Models is Prone to Oxidatively Generated Damage Resulting in Dehydroguanidinohydantoin and Spiroiminodihydantoin Lesions
Authors: Tomaszewska‐Antczak Agnieszka , Guga Piotr , Nawrot Barbara , Pratviel Geneviève 
Published: March 2015

AbstractOxidation of RNA hairpin models corresponding to anticodon stem–loop (ASL) of transfer RNA led to RNA damage consisting solely of a unique loop guanine oxidation. Manganese porphyrin/oxone treatment of RNA resulted in dehydroguanidinohydantoin (DGh; major) and/or spiroiminodihydantoin (Sp) lesions. Ribose damage was not observed. This two‐electron transfer oxidation reaction allowed the identification of guanine oxidation products for further study of RNA species carrying a unique lesion at a single G to investigate their biological impact.
Entwicklung und Einsatz von Gasdiffusionselektroden zur elektrochemischen Reduktion von CO2
Authors: Kopljar Dennis , Inan Andrea , Vindayer Patrick , Scholz Ralf , Frangos Nicolaos , Wagner Norbert , Klemm Elias 
Published: March 2015

AbstractDie elektrochemische Verwertung von CO2 ist eine vielversprechende Möglichkeit zu dessen stofflicher Nutzung und zur chemischen Speicherung von elektrischem Strom. Um die Limitierung der Stromdichten durch die begrenzte Löslichkeit des CO2 zu umgehen, wurden Gasdiffusionselektroden mit Zinn als Elektrokatalysator entwickelt und ihre Eignung in der Reduktion von CO2 getestet. Durch ihren Einsatz ist es möglich, die erreichbaren Stromdichten von ca. 10 auf bis zu 200 mA cm−2 bei einer Faraday‐Effizienz von 90 % zu steigern, bevor Stofftransportlimitierung einsetzt. Zudem wurden erste Versuche im mikrostrukturierten Reaktor durchgeführt, die die Übertragung vom Semi‐Batch zum kontinuierlichen Betrieb beschreiben.
Modulares Mikroreaktorsystem aus ultraschallheißgeprägten Polymerfolien
Authors: Tollkötter Alexander , Sackmann Johannes , Baldhoff Tobias , Schomburg Werner Karl , Kockmann Norbert 
Published: March 2015

AbstractVerkürzte Entwicklungszeiten chemischer Prozesse sind durch Laborexperimente und Erkenntnisse daraus möglich. Dies wird durch modulare Mikrosysteme und deren Standardisierung der Apparate vereinfacht. Kunststoffe bieten durch ihre variablen Materialeigenschaften die Anpassung an die jeweiligen Prozesse sowie kostengünstige Herstellung. Das modulare Konzept besteht aus ultraschallheißgeprägten PVDF‐Folien. Zwei mögliche Anordnungsvarianten werden bezüglich ihrer Charakteristiken und der Verbindungsarten einzelner Module diskutiert. Die Durchführung einer Neutralisationsreaktion zeigt die Flexibilität dieses modularen Systems hinsichtlich Prozessanforderungen.
A Chemical Chaperone‐Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS)
Authors: Getter Tamar , Zaks Ilana , Barhum Yael , Ben‐Zur Tali , Böselt Sebastian , Gregoire Simpson , Viskind Olga , Shani Tom , Gottlieb Hugo , Green Omer , Shubely Moran , Senderowitz Hanoch , Israelson Adrian , Kwon Inchan , Petri Susanne , Offen Daniel , Gruzman Arie 
Published: March 2015

AbstractAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective death of motor neurons and skeletal muscle atrophy. The majority of ALS cases are acquired spontaneously, with inherited disease accounting for only 10 % of all cases. Recent studies provide compelling evidence that aggregates of misfolded proteins underlie both types of ALS. Small molecules such as artificial chaperones can prevent or even reverse the aggregation of proteins associated with various human diseases. However, their very high active concentration (micromolar range) severely limits their utility as drugs. We synthesized several ester and amide derivatives of chemical chaperones. The lead compound 14, 3‐((5‐((4,6‐dimethylpyridin‐2‐yl)methoxy)‐5‐oxopentanoyl)oxy)‐N,N‐dimethylpropan‐1‐amine oxide shows, in the micromolar concentration range, both neuronal and astrocyte protective effects in vitro; at daily doses of 10 mg kg−1 14 improved the neurological functions and delayed body weight loss in ALS mice. Members of this new chemical chaperone derivative class are strong candidates for the development of new drugs for ALS patients.
Correlation of gene methylation in surgical margin imprints with locoregional recurrence in head and neck squamous cell carcinoma
Authors: Hayashi Masamichi , Wu Gaosong , Roh Jong‐Lyel , Chang Xiaofei , Li Xiufeng , Ahn Julie , Goldsmith Marla , Khan Zubair , Bishop Justin , Zhang Zhe , Zhou Xian Chong , Richmon Jeremy , Agrawal Nishant , Koch Wayne M. 
Published: March 2015

BACKGROUNDSecuring negative surgical margins is a critical goal for head and neck surgery. Local recurrence develops even in some patients who have histologically negative surgical margins. Minimal residual tumor cells may lead to locoregional recurrence despite clear histologic margins reported at the time of resection of head and neck squamous cell carcinoma (HNSCC). To identify subclinical residual disease, the authors analyzed deep margin imprint samples collected on 1‐layer nitrocellulose sheets.METHODSBisulfite‐treated DNA samples from 73 eligible patients were amplified by quantitative methylation‐specific polymerase chain reaction (QMSP) targeting 6 genes (deleted in colorectal cancer [DCC], endothelin receptor type B [EDNRB], homeobox protein A9 [HOXA9], kinesin family member 1A [KIF1A], nidogen‐2 [NID2], and N‐methyl D‐aspartate receptor subtype 2B [NR2B]). QMSP values were dichotomized as positive or negative. Associations between the QMSP status of deep margin samples and clinical outcomes were evaluated.RESULTSTwo‐gene methylation combinations among the genes DCC, EDNRB, and HOXA9 were associated with decreased locoregional recurrence‐free survival, recurrence‐free survival, and overall survival. The methylated gene combination of EDNRB and HOXA9 in margin imprints was the most powerful predictor of poor locoregional recurrence‐free survival (hazard ratio [HR], 3.31; 95% confidence interval [CI], 1.30‐8.46; P = .012) independent of standard histologic factors. In addition, methylation of both EDNRB and HOXA9 indicated a trend toward reduced recurrence‐free survival (HR, 2.74; 95% CI, 0.90‐8.33; P = .075) and reduced OS (HR, 5.78; 95% CI, 0.75‐44.7; P = .093) in multivariable analysis.CONCLUSIONSA panel of gene methylation targets in deep surgical margin imprints provides a potential predictive marker of postoperative locoregional recurrence. Intraoperative use of molecular margin imprint analysis may assist surgeons in obtaining rigorously negative surgical margins and improve the outcome of head and neck surgery. Cancer 2015;121:1957–1965. © 2015 American Cancer Society.
A hypomorphic allele reveals an important role of inturned in mouse skeletal development
Authors: Chang Rachel , Petersen Juliette R. , Niswander Lee A. , Liu Aimin 
Published: March 2015

ABSTRACTBackground: Cilia are important for Hedgehog signaling in vertebrates and many genes that encode proteins involved in ciliogenesis have been studied for their roles in embryonic development. Null mutations in many of these genes cause early embryonic lethality, hence an understanding of their roles in postnatal development is limited. Results: The Inturned (Intu) gene is required for ciliogenesis and here we report a recessive hypomorphic mutation, resulting in substitution of a conserved hydrophobic residue (I813N) near the C‐terminus, that sheds light on later functions of Intu. Mice homozygous for this Double‐thumb (IntuDtm) allele exhibit polydactyly, retarded growth, and reduced survival. There is a moderate loss of cilia in IntuDtm/Dtm mutants, and IntuI813N exhibits compromised ability to increase ciliogenesis in cultured Intu null mutant cells. IntuDtm mutants show rib defects and delay of endochondral ossification in long bones, digits, vertebrae, and the sternum. These skeletal defects correlate with a decrease in Hh signaling. However, patterning of the neural tube and planar cell polarity appear to be normal. Conclusions: This hypomorphic Intu allele highlights an important role of Intu in mouse skeletal development. Developmental Dynamics 244:736–747, 2015. © 2015 Wiley Periodicals, Inc.
Niobium–Containing Lindqvist Isopolyanions [NbxW6–xO19](2+x)– Used as Precursors for Hydrodesulfurization Catalysts with Isomerization Properties
Authors: Bouadjadja‐Rohan Karolina , Lancelot Christine , Fournier Michel , Bonduelle‐Skrzypczak Audrey , Hugon Antoine , Mentré Olivier , Lamonier Carole 
Published: March 2015

AbstractLindqvist isopolyanions [NbxW6–xO19](2+x)– (x = 0–4 and 6) were prepared and their spectroscopic and thermal properties were determined by Raman and IR spectroscopy as well as TGA/DSC. The structure of the [NbW5O19]3– anion obtained as single crystal was determined. Ni‐promoted alumina‐supported hydrodesulfurization (HDS) catalysts were prepared from the best soluble NbW polyoxometalates. In the calcined catalysts, better dispersion of the metallic species is observed when using NbW isopolyanions instead of the conventional ammonium metatungstate. The presence of niobium was expected to introduce acidity leading to isomerization property in classical NiW HDS catalysts. In HDS reaction conditions (under hydrogen pressure and sulfided environment) the cyclohexane isomerization into methylcyclopentane activity of niobium‐based catalysts was found up to 5 times superior to that of conventional NiW catalyst, showing the beneficial effect of niobium for this reaction.