bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validated HPLC‐UV method for determination of naproxen in human plasma with proven selectivity against ibuprofen and paracetamol
Authors: Filist Monika , Szlaska Iwona , Kaza Michał , Pawiński Tomasz 
Published: October 2015

AbstractEstimating the influence of interfering compounds present in the biological matrix on the determination of an analyte is one of the most important tasks during bioanalytical method development and validation. Interferences from endogenous components and, if necessary, from major metabolites as well as possible co‐administered medications should be evaluated during a selectivity test. This paper describes a simple, rapid and cost‐effective HPLC‐UV method for the determination of naproxen in human plasma in the presence of two other analgesics, ibuprofen and paracetamol. Sample preparation is based on a simple liquid–liquid extraction procedure with a short, 5 s mixing time. Fenoprofen, which is characterized by a similar structure and properties to naproxen, was first used as the internal standard. The calibration curve is linear in the concentration range of 0.5–80.0 µg/mL, which is suitable for pharmacokinetic studies following a single 220 mg oral dose of naproxen sodium. The method was fully validated according to international guidelines and was successfully applied in a bioequivalence study in humans. Copyright © 2015 John Wiley & Sons, Ltd.
Trade‐offs in corporate sustainability: you can't have your cake and eat it
Authors: Hahn Tobias , Figge Frank , Pinkse Jonatan , Preuss Lutz 
Published: October 2015

AbstractThe mainstream of the literature on corporate sustainability follows the win–win paradigm, according to which economic, environmental and social sustainability aspects can be achieved simultaneously; indeed, corporate sustainability has often been defined by the intersection of these three areas. However, given the multi‐faceted and complex nature of sustainable development, we argue that trade‐offs and conflicts in corporate sustainability are the rule rather than the exception. Turning a blind eye to trade‐offs thus results in a limited perspective on corporate contributions to sustainable development. In order to overcome this situation, we propose an initial framework for the analysis of trade‐offs in corporate sustainability. By doing so, we pursue two aims. First, the framework serves as a starting point for a more systematic analysis of trade‐offs in corporate sustainability, as it identifies different levels and dimensions to characterize such trade‐offs. Second, it serves to contextualize the contributions to this special issue on trade‐offs in corporate sustainability. Based on the framework, we finally point to some promising avenues for future research on trade‐offs in, and a more inclusive notion of, corporate sustainability. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment.
Metatheoretical snowmen: A pedagogicalgedankenexperimentin information metatheory
Authors: Hartel Jenna 
Published: October 2015

AbstractEditor's SummaryMetatheory is the highest level conceptual device used in social scientific research and determines a way of thinking and speaking about reality and its information phenomena. Today, numerous metatheories exist in information science and create a dynamic climate. There is also widespread confusion about metatheory because it is a relatively new, abstract and elusive concept for students, practitioners and scholars alike. The article introduces metatheory in information science and its ontological, methodological, social and personal implications. Then “Metatheoretical Snowmen,” a novel pedagogical strategy, is described. Metatheoretical Snowmen demystifies information metatheory through a gedankenexperiment, that is, a thought experiment. In Metatheoretical Snowmen, participants apply the characteristics of a variety of information metatheories to the life and information experience of an ordinary and affable persona: a snowman. The renderings of the snowman and its information world bring the special features of each metatheory into clear view. This approach has been implemented to positive effect as a panel presentation at international conferences in information science, including two recent Annual Meetings of the American Society for Information Science and Technology (ASIS&T).
Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC‐TT cell line
Authors: Tesfazghi Sara , Eide Jacob , Dammalapati Ajitha , Korlesky Colin , Wyche Thomas P. , Bugni Tim S. , Chen Herbert , Jaskula‐Sztul Renata 
Published: October 2015

AbstractMedullary thyroid cancer (MTC) is an aggressive neuroendocrine tumor (NET). Previous research has shown that activation of Notch signaling has a tumor suppressor role in NETs. The potential therapeutic effect of thiocoraline on the activation of the Notch pathway in an MTC cell line (TT) was investigated. Thiocoraline was isolated from a marine bacterium Verrucosispora sp. MTT assay (3‐[4, 5‐dimethylthiazole‐2‐yl]‐2, 5‐diphenyltetrazolium bromide) was used to determine the IC50 value and to measure cell proliferation. Western blot revealed the expression of Notch isoforms, NET, and cell cycle markers. Cell cycle progression was validated by flow cytometry. The mRNA expression of Notch isoforms and downstream targets were measured using real‐time PCR. The IC50 value for thiocoraline treatment in TT cells was determined to be 7.6 nmol/L. Thiocoraline treatment decreased cell proliferation in a dose‐ and time‐dependent manner. The mechanism of growth inhibition was found to be cell cycle arrest in G1 phase. Thiocoraline activated the Notch pathway as demonstrated by the dose‐dependent increase in mRNA and protein expression of Notch isoforms. Furthermore, treatment with thiocoraline resulted in changes in the expression of downstream targets of the Notch pathway (HES1, HES2, HES6, HEY1, and HEY2) and reduced expression of NET markers, CgA, and ASCL1. Thiocoraline is a potent Notch pathway activator and an inhibitor of MTC‐TT cell proliferation at low nanomolar concentrations. These results provide exciting evidence for the use of thiocoraline as a potential treatment for intractable MTC.
The Genus Neolitsea of Lauraceae: A Phytochemical and Biological Progress
Authors: Cao Yuan , Gao Xiao‐Li , Su Guo‐Zhu , Yu Xue‐Long , Tu Peng‐Fei , Chai Xing‐Yun 
Published: October 2015

AbstractAs one of the biggest genera in Lauraceae, Neolitsea owns a great application potential in industrial and traditional medical fields. Modern phytochemical and biological investigations revealed its structural diversity and diverse activities. This review summarizes the most recent progress on this regards, hopefully to provide a reference for full use and development of the Neolitsea resource.
Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffeliiGriseb. ex Heuff. and Its Metabolites
Authors: Pavlović Ivan , Petrović Silvana , Milenković Marina , Stanojković Tatjana , Nikolić Dejan , Krunić Aleksej , Niketić Marjan 
Published: October 2015

AbstractThe antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffelii Griseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram‐positive than Gram‐negative bacteria, especially against Staphylococcus aureus (MIC=12.5 μg/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5 μg/ml, resp.). Among the tested metabolites, (6E)‐1‐(2,4‐dihydroxyphenyl)‐3,7,11‐trimethyl‐3‐vinyldodeca‐6,10‐dien‐1‐one (2) and (2S*,3R*)‐2‐[(3E)‐4,8‐dimethylnona‐3,7‐dien‐1‐yl]‐2,3‐dihydro‐7‐hydroxy‐2,3‐dimethylfuro[3,2‐c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2 μM, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5 μM, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2 μM). The cytotoxic activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF‐7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50<11.0 μg/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF‐7 cell line, comparable to that of cisplatin (IC50=22.32±1.32 vs. 18.67±0.75μM).
Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti
Authors: Zhu Hucheng , Chen Chunmei , Wang Jianping , Li Xiao‐Nian , Wei Guangzheng , Guo Yi , Yao Guangmin , Luo Zengwei , Zhang Jinwen , Xue Yongbo , Zhang Yonghui 
Published: October 2015

AbstractA highly oxygenated hexacyclic indole alkaloid, penicamedine A (1), bearing a rare furan ring, was isolated from the culture broth of Penicillium camemberti, together with two known analogs, iso‐α‐cyclopiazonic acid (2) and cyclopiazonic acid (3). The structure of 1 was elucidated by comprehensive spectroscopic analyses including NMR and HR‐ESI‐MS. Its absolute configuration was further confirmed unambiguously by single‐crystal X‐ray diffraction analysis. Compound 1 was evaluated for anti‐HIV activity with p24 assays and tested for cytotoxic activities against five human cancer cell lines, including HL‐60, SMMC‐7721, A‐549, MCF‐7, SW480, and the immortalized non‐cancerous human pulmonary epithelial cell line BEAS‐2B by MTS method.
Plant Volatilome in Greece: a Review on the Properties, Prospects, and Chemogeography
Authors: Kantsa Aphrodite , Sotiropoulou Stavroula , Vaitis Michail , Petanidou Theodora 
Published: October 2015

AbstractKnowing plant volatile chemodiversity and its distribution is essential in order to study biological processes, to estimate the plants' value in use, and to establish sustainable exploitation practices. Yet, attempts to collect and assess data on scent diversity and properties in well‐defined geographical areas are rare. Here, we developed a geo‐referenced database of the plant volatilome in Greece by consolidating the results included in 116 research articles published in the last 25 years. The data set compiled includes 999 volatile organic compounds distributed into 178 plant taxa, 59 genera, and 19 families. Distillation is the acquisition method almost exclusively used, whereas headspace techniques that would allow the study of subtle ecological processes are generally lacking. Sesquiterpenes show the greatest richness of compounds, followed by monoterpenes and aliphatics. We assess the volatility of the compounds using the normal boiling point (nBP) as its reverse indicator, and we present the volatility spectra of the blends of the genera studied. Mean nBPs vary among genera, with maximal differences as wide as 118.4°. Finally, we feature basic chemodiversity maps for three aromatic plants, and discuss their importance and prospects as a special case of natural resources maps.
An evaluation of case formulation training and consultation with probation officers
Authors: Minoudis Philip , Craissati Jackie , Shaw Jake , McMurran Mary , Freestone Mark , Chuan Stuart J. , Leonard Ania 
Published: October 2015

AbstractBackgroundFormulation is a core competency of mental health professionals, drawing on a variety of sources of information. In England and Wales, the current strategy for offenders with personality disorder places formulation‐led management, generally by probation staff, at its core, but reliability and validity of the process remain unclear.AimsThe first aim was to evaluate a checklist previously designed to establish quality of formulation, and the second to measure the impact of training and consultation on the ability of probation officers to formulate cases.MethodsThe inter‐rater reliability, test–re‐test reliability and internal consistency of the McMurran formulation checklist were calculated from the scores derived from randomised formulations completed by probation officers from fictitious case vignettes. The impact of training was measured by comparing pre‐ and post‐training formulations of these vignettes. Practice cases formulated by probation officers at psychologist‐facilitated consultation meetings over a 6‐month period were used to measure the impact of consultation. All formulations were scored blind by independent experts.ResultsInter‐rater reliability, test–re‐test reliability and internal consistency of the scale were all acceptable. Training and practice did not significantly improve the probation officers' formulations.ConclusionsThe purpose and utility of formulation may vary according to the context in which it is applied. Progress in developing formulation skills may depend on the nature and length of the previous experience of this skill. Future research should take account of such variance, with this scale as a potentially useful aid in monitoring progress.ImplicationsThe capacity for teaching formulation to probation officers could be investigated further by comparing the process with formulation development by mental health experts with previously extensive formulation experience.Formulation will probably need to be adapted to meet the needs of the context in which it is developed.The relationship between formulation and management outcome was not investigated here and would be a further important step. Copyright © 2013 John Wiley & Sons, Ltd.
Efficient Biomimetic Hydroxylation Catalysis with a Bis(pyrazolyl)imidazolylmethane Copper Peroxide Complex
Authors: Wilfer Claudia , Liebhäuser Patricia , Hoffmann Alexander , Erdmann Hannes , Grossmann Oleg , Runtsch Leander , Paffenholz Eva , Schepper Rahel , Dick Regina , Bauer Matthias , Dürr Maximilian , Ivanović‐Burmazović Ivana , Herres‐Pawlis Sonja 
Published: October 2015

AbstractBis(pyrazolyl)methane ligands are excellent components of model complexes used to investigate the activity of the enzyme tyrosinase. Combining the N donors 3‐tert‐butylpyrazole and 1‐methylimidazole results in a ligand that is capable of stabilising a (μ‐η2:η2)‐dicopper(II) core that resembles the active centre of tyrosinase. UV/Vis spectroscopy shows blueshifted UV bands in comparison to other known peroxo complexes, due to donor competition from different ligand substituents. This effect was investigated with the help of theoretical calculations, including DFT and natural transition orbital analysis. The peroxo complex acts as a catalyst capable of hydroxylating a variety of phenols by using oxygen. Catalytic conversion with the non‐biological phenolic substrate 8‐hydroxyquinoline resulted in remarkable turnover numbers. In stoichiometric reactions, substrate‐binding kinetics was observed and the intrinsic hydroxylation constant, kox, was determined for five phenolates. It was found to be the fastest hydroxylation model system determined so far, reaching almost biological activity. Furthermore, Hammett analysis proved the electrophilic character of the reaction. This sheds light on the subtle role of donor strength and its influence on hydroxylation activity.
Electrocatalytic Dioxygen Reduction by Carbon Electrodes Noncovalently Modified with Iron Porphyrin Complexes: Enhancements from a Single Proton Relay
Authors: Sinha Soumalya , Aaron Michael S. , Blagojevic Jovan , Warren Jeffrey J. 
Published: October 2015

AbstractOxygen reduction in acidic aqueous solution mediated by a series of asymmetric iron (III)‐tetra(aryl)porphyrins adsorbed to basal‐ and edge‐ plane graphite electrodes is investigated. The asymmetric iron porphyrin systems bear phenyl groups at three meso positions and either a 2‐pyridyl, a 2‐benzoic acid, or a 2‐hydroxyphenyl group at the remaining meso position. The presence of the three unmodified phenyl groups makes the compounds insoluble in water, enabling catalyst retention during electrochemical experiments. Resonance Raman data demonstrate that catalyst layers are maintained, but can undergo modification after prolonged catalysis in the presence of O2. The introduction of a single proton relay group at the fourth meso position makes the asymmetric iron porphyrins markedly more robust catalysts; these molecules support higher sustained current densities than the parent iron tetraphenylporphyrin. Iron porphyrins bearing a 2‐pyridyl group are the most active catalysts and operate at stable current densities ≥1 mA cm−2 for over 5 h. Comparative analysis of the catalysts with different proton relays also is reported.
Reversible Assembly of a Supramolecular Cage Linked by Boron–Nitrogen Dative Bonds
Authors: Dhara Ayan , Beuerle Florian 
Published: October 2015

AbstractBoron–nitrogen dative bonds provide a suitable motif for reversible, yet strong and directed interactions, leading to the highly efficient self‐assembly of small organic building blocks into supramolecular cage structures. A bipyramidal [2+3] assembly, as the first example of a supramolecular cage mediated by BN dative bonds that exists as a discrete species in solution, is quantitatively obtained from a tribenzotriquinacene‐based trisboronate ester and 1,4‐diazabicyclo[2.2.2]octane. Thermodynamic equilibria of cage formation are investigated by isothermal titration calorimetry and fully reversible cage opening can be observed at elevated temperatures.
Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal–Organic Framework
Authors: Sun Raymond Wai‐Yin , Zhang Ming , Li Dan , Zhang Zhi‐Feng , Cai Hong , Li Mian , Xian Yue‐Jiao , Ng Seik Weng , Wong Alice Sze‐Tsai 
Published: October 2015

AbstractA dinuclear gold(I) pyrrolidinedithiocarbamato complex (1) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin‐resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)‐based metal–organic framework (Zn‐MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug‐release testing, in this study, a set of transwell assay‐based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1@Zn‐MOF towards A2780cis.
ChemInform Abstract: Syntheses and Structures of Na2Mg3(OH)2 (SO4)3·4H2O and K2Mg3(OH)2 (SO4)3·2H2O.
Authors: Kubel Frank , Cabaret‐Lampin Marie 
Published: October 2015

AbstractThe title compounds are prepared from stoichiometric mixtures of MgO, MgSO4, Na2SO4, or K2SO4 with small amounts of H2O by heating to 150 °C for 12 h and drying.
ChemInform Abstract: Synthesis, Structure and Electrochemical Properties of Layered La2Li2x(CO3)1‐xO2+2x.
Authors: Iqbal Muhammad , Kobayashi Genki , Hirayama Masaaki , Kanno Ryoji 
Published: October 2015

AbstractLa2Li2x(CO3)1‐xO2+2x (x = 0.15) is prepared by solid‐state reaction of Li2CO3 and La2(C2O4)3 at 600 °C.
ChemInform Abstract: A Green Synthesis of a Layered Titanate, Potassium Lithium Titanate; Lower Temperature Solid‐State Reaction and Improved Materials Performance.
Authors: Ogawa Makoto , Morita Masashi , Igarashi Shota , Sato Soh 
Published: October 2015

AbstractKxTi2‐x/3Lix/3O4 (x: 0.8) is prepared by solid state reaction of K2CO3, Li2CO3, and TiO2 in a molar ratio of 2.4:0.8:10.4 (800 °C, 20 h).
ChemInform Abstract: Malonic Ester Amide Synthesis: An Efficient Methodology for Synthesis of Amides.
Authors: Mahajan Pankaj S. , Mahajan Jyoti P. , Mhaske Santhosh B. 
Published: October 2015

AbstractA general and efficient methodology for the decarboxylative acylation of various amines by diethyl malonates is developed furnishing one‐carbon homologated amides in good to excellent yields.
ChemInform Abstract: Gold Catalysis: Highly Functionalized Cyclopentadienes Prepared by Intermolecular Cyclization of Ynamides and Propargylic Carboxylates.
Authors: Rettenmeier Eva , Schuster Andreas M. , Rudolph Matthias , Rominger Frank , Gade Christoph A. , Hashmi A. Stephen K. 
Published: October 2015

AbstractA wide range of highly substituted cyclopentadienes can be synthesized under mild reaction conditions and with complete atom economy.
ChemInform Abstract: Palladium‐Catalyzed ortho‐Selective C—F Activation of Polyfluoroarenes with Triethylsilane: A Facile Access to Partially Fluorinated Aromatics.
Authors: Chen Zhao , He Chun‐Yang , Yin Zengsheng , Chen Liye , He Yi , Zhang Xingang 
Published: October 2015

AbstractThe efficient and versatile title reaction gives access to fluoroarenes which are difficult to synthesize otherwise.
ChemInform Abstract: Solvent‐ and Catalyst‐Free Direct Reductive Amination of Aldehydes and Ketones with Hantzsch Ester: Synthesis of Secondary and Tertiary Amines.
Authors: Nguyen Quynh Pham Bao , Kim Taek Hyeon 
Published: October 2015

AbstractThe parallel synthesis of a series of secondary and tertiary amines is achieved by the direct reductive amination of aldehydes and ketones with a biomimetic and safe reducing agent under solvent‐ and catalyst‐free as well as metal‐ and acid‐free conditions.
ChemInform Abstract: Solvent‐Free Selective Oxidation of Primary and Secondary Alcohols Catalyzed by Ruthenium‐bis(benzimidazole)pyridinedicarboxylate Complex Using Hydrogen Peroxide as an Oxidant.
Authors: Zhou Xian‐Tai , Ji Hong‐Bing , Liu Sheng‐Gui 
Published: October 2015

AbstractThe title oxidation proceeds under mild reaction conditions to give the corresponding aldehydes and ketones in good yields and excellent selectivity.
ChemInform Abstract: L‐Proline Catalyzed One Pot Synthesis of α‐Aminonitriles.
Authors: Nasreen Aayesha 
Published: October 2015

Abstractα‐Aminonitriles are easily synthesized under mild conditions via a one‐pot three‐component reaction of aldehydes, amines, and trimethylsilyl cyanide in the presence of L‐proline as the catalyst.
ChemInform Abstract: Selective Construction of Aliphatic Polycycles Utilizing Platinum‐Catalyzed Cyclization of 2‐(Enynyl)cycloalkenals.
Authors: Han Jin Wook , Lee Ji Ho , Oh Chang Ho 
Published: October 2015

AbstractOptimized reaction conditions including PtCl2 as the catalyst are developed for the cyclization of enynals to give tricyclic cycloheptadienone derivatives.
ChemInform Abstract: Organocatalytic Asymmetric Remote Aziridination of 2,4‐Dienals.
Authors: Halskov Kim Soeholm , Naicker Tricia , Jensen Magnus E. , Joergensen Karl Anker 
Published: October 2015

AbstractIn general E:Z‐ as well as γ,δ:α,β‐selectivities <19:1 are observed.
ChemInform Abstract: Unusual Skeletal Rearrangement of Unsaturated Seven‐Membered Lactams into Fused Pyrrolidinolactones.
Authors: Alvarez Silvia , Dominguez Gema , Gradillas Ana , Perez‐Castells Javier 
Published: October 2015

AbstractSeveral subsequent modifications of the lactone functionality of the reaction products are exemplified.
ChemInform Abstract: Construction of Cyclohepta[b]indoles via Platinum‐Catalyzed Intermolecular Formal [4 + 3]‐Cycloaddition Reaction of α,β‐Unsaturated Carbene Complex Intermediates with Siloxydienes.
Authors: Kusama Hiroyuki , Sogo Hideyuki , Saito Kodai , Suga Takuya , Iwasawa Nobuharu 
Published: October 2015

AbstractThis unique reaction allows the synthesis of the title compounds under mild reaction conditions.
ChemInform Abstract: Synthesis, Antifungal and Cytotoxic Activities of 2‐Aryl‐3‐((piperidin‐1‐yl)ethyl)thiazolidinones.
Authors: Kunzler Alice , Neuenfeldt Patricia D. , das Neves Adriana M. , Pereira Claudio M. P. , Marques Gabriela H. , Nascente Patricia S. , Fernandes Maureen H. V. , Huebner Silvia O. , Cunico Wilson 
Published: October 2015

AbstractDerivatives (IVc) and (IVf) exhibit activity against Rhodotorula sp.
ChemInform Abstract: 2‐Aminobenzothiazole Derivatives: Search for New Antifungal Agents.
Authors: Catalano Alessia , Carocci Alessia , Defrenza Ivana , Muraglia Marilena , Carrieri Antonio , Van Bambeke Francoise , Rosato Antonio , Corbo Filomena , Franchini Carlo 
Published: October 2015

AbstractDerivatives (IIe, f) show the highest activity against Candida albicans, Candida parapsilosis and Candida tropicalis along with no cytotoxic effect on human THP‐1 cells.