bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transgenic mice over-expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction
Authors: Zheng Yabing , Wang Lin , Zhang Wei , Xu Hengwei , Chang Xiaotian 
Published: December 2012

Abstract

Background
Studies have demonstrated that carbonic anhydrase I (CA1) stimulates calcium salt precipitation and cell calcification, which is an essential step in new bone formation. Our study had reported that CA1 encoding gene has a strong association with rheumatoid arthritis (RA) and ankylosing spondylitis (AS), two rheumatic diseases with abnormal new bone formation and bone resorption in joints. This study investigated the effect of CA1 on joint inflammation and tissue destruction in transgenic mice that over-express CA1 (CA1-Tg).

Methods
CA1-Tg was generated with C57BL/6J mice by conventional methods. CA1-Tg was treated with collagen-II to induce arthritis (CIA). Wild-type mice, CA1-Tg treated with bovine serum albumin (BSA) and transgenic mice over-expressing PADI4 (PADI4-Tg), a gene known to be involved in rheumatoid arthritis, were used as controls. Histochemistry and X-ray radiographic assay were used to examine joint destruction. Western blotting and real time-PCR were used to examine CA1 expression.

Results
CIA was observed in 60% of CA1-Tg, 20% of PADI4-Tg and 20% of wild-type mice after collagen injections. No CIA was found in CA1-Tg mice that received injections of BSA. The arthritic score was 5.5 ± 0.84 in the CA1-Tgs but the score was less than 2 in the injected wild-type mice and the PADI4-Tgs. The thickness of the hind paws in the CA1-Tgs was 3.46 ± 0.11 mm, which was thicker than that of PADI4-Tgs (2.23 ± 0.08 mm), wild-type mice (2.08 ± 0.06 mm) and BSA-treated CA1-Tgs (2.04 ± 0.07 mm). Histochemistry showed obvious inflammation, synovial hyperplasia and bone destruction in the joints of CA1-Tg that was not detected in PADI4-Tgs or wild-type mice. X-ray assays showed bone fusion in the paws and spines of CA1-Tg mice.

Conclusion
Over-expression of CA1 may aggravate joint inflammation and tissue destruction in the transgenic mice.
Iterative development of MobileMums: a physical activity intervention for women with young children
Authors: Fjeldsoe Brianna S , Miller Yvette D , O’Brien Jasmine L , Marshall Alison L 
Published: December 2012

Abstract

Background
To describe the iterative development process and final version of ‘MobileMums’: a physical activity intervention for women with young children (<5 years) delivered primarily via mobile telephone (mHealth) short messaging service (SMS).

Methods
MobileMums development followed the five steps outlined in the mHealth development and evaluation framework: 1) conceptualization (critique of literature and theory); 2) formative research (focus groups, n= 48); 3) pre-testing (qualitative pilot of intervention components, n= 12); 4) pilot testing (pilot RCT, n= 88); and, 5) qualitative evaluation of the refined intervention (n= 6).

Results
Key findings identified throughout the development process that shaped the MobileMums program were the need for: behaviour change techniques to be grounded in Social Cognitive Theory; tailored SMS content; two-way SMS interaction; rapport between SMS sender and recipient; an automated software platform to generate and send SMS; and, flexibility in location of a face-to-face delivered component.

Conclusions
The final version of MobileMums is flexible and adaptive to individual participant’s physical activity goals, expectations and environment. MobileMums is being evaluated in a community-based randomised controlled efficacy trial (ACTRN12611000481976).
Cellular responses induced by Cu(II) quinolinonato complexes in human tumor and hepatic cells
Authors: Trávníček Zdeněk , Vančo Ján , Hošek Jan , Buchtík Roman , Dvořák Zdeněk 
Published: December 2012

Abstract

Background
Inspired by the unprecedented historical success of cisplatin, one of the most important research directions in bioinorganic and medicinal chemistry is dedicated to the development of new anticancer compounds with the potential to surpass it in antitumor activity, while having lower unwanted side-effects. Therefore, a series of copper(II) mixed-ligand complexes of the type [Cu(qui)(L)]Y · xH2O (1–6), where Hqui = 2-phenyl-3-hydroxy-4(1H)-quinolinone, Y = NO3 (1, 3, 5) or BF4 (2, 4, 6), and L = 1,10-phenanthroline (phen) (1, 2), 5-methyl-1,10-phenanthroline (mphen) (3, 4) and bathophenanthroline (bphen) (5, 6), was studied for their in vitro cytotoxicity against several human cancer cell lines (A549 lung carcinoma, HeLa cervix epitheloid carcinoma, G361 melanoma cells, A2780 ovarian carcinoma, A2780cis cisplatin-resistant ovarian carcinoma, LNCaP androgen-sensitive prostate adenocarcinoma and THP-1 monocytic leukemia).

Results
The tested complexes displayed a stronger cytotoxic effect against all the cancer cells as compared to cisplatin. The highest cytotoxicity was found for the complexes 4 (IC50 = 0.36 ± 0.05 μM and 0.56 ± 0.15 μM), 5 (IC50 = 0.66 ± 0.07 μM and 0.73 ± 0.08 μM) and 6 (IC50 = 0.57 ± 0.11 μM and 0.70 ± 0.20 μM) against A2780, and A2780cis respectively, as compared with the values of 12.0 ± 0.8 μM and 27.0 ± 4.6 μM determined for cisplatin. Moreover, the tested complexes were much less cytotoxic to primary human hepatocytes than to the cancer cells. The complexes 5 and 6 exhibited significantly high ability to modulate secretion of the pro-inflammatory cytokines TNF-α (2873 ± 238 pg/mL and 3284 ± 139 pg/mL for 5, and 6 respectively) and IL-1β (1177 ± 128 pg/mL and 1087 ± 101 pg/mL for 5, and 6 respectively) tested on the lipopolysaccharide (LPS)-stimulated THP-1 cells as compared with the values of 1173 ± 85 pg/mL and 118.5 ± 4.8 pg/mL found for the commercially used anti-inflammatory drug prednisone. The ability of the tested complexes to interact with sulfur-containing biomolecules (cysteine and reduced glutathione) at physiological levels was proved by electrospray-ionization mass spectrometry.

Conclusions
Overall positive results of the biological activity studies revealed that the presented complexes may represent good candidates for non-platinum anticancer drugs, however, we are aware of the fact that further and deeper studies mainly in relation to the elucidation of their mechanisms of antiproliferative action will be necessary.
An adaptively emerging mechanism for context-aware service selections regulated by feedback distributions
Authors: Zhu Yishui , Jin Qun 
Published: December 2012

Abstract
Background
In the cloud computing environments, numerous ambient services may be created speedily and provided to a variety of users. In such a situation, people may be annoyed by how to make a proper and optimal selection quickly and economically.

Methods
In this study, we propose an Adaptively Emerging Mechanism (AEM) to reduce this selection burden with an interdisciplinary approach. AEM is applied and integrated into the Flowable Service Model (FSM), which has been proposed and developed in our previous study. We consider the user’s feedback information is a pivotal factor for AEM, which contains the user’s satisfaction degree after using the services. At the same time, we assume that these factors, such as the service cost, matching result precision, responding time, personal and social context information, etc., are essential parts of the optimizing process for the selection of ambient services.

Results and Conclusion
By analyzing the result of AEM simulation, we reveal that AEM can (1) substantially improve the selection process for LOW feedback users; (2) bring no negative effect on the selection process for MEDIUM or HIGH feedback users; and (3) enhance the rationality for services selection.
What Did We Learn from Research on Comorbidity In Psychiatry? Advantages and Limitations in the Forthcoming DSM-V Era
Authors: Dell’Osso Liliana , Pini Stefano 
Published: December 2012

Despite the large amount of research conducted in this area over the last two decades, comorbidity of psychiatric disorders remains a topic of major practical and theoretical significance.Official diagnostic and therapeutic guidelines of psychiatric disorders still do not provide clinicians and researchers with any treatment-specific indications for those cases presenting with psychiatric comorbidity. We will discuss the diagnostic improvement brought about, in clinical practice, by the punctual and refined recognition of threshold and subthreshold comorbidity. From such a perspective, diagnostic procedures and forthcoming systems of classification of mental disorders should attempt to combine descriptive, categorical and dimensional approaches, addressing more attention to the cross-sectional and longitudinal analysis of nuclear, subclinical, and atypical symptoms that may represent a pattern of either full-blown or partially expressed psychiatric comorbidity. This should certainly be regarded as a positive development. Parallel, continuous critical challenge seems to be vital in this area, in order to prevent dangerous trivializations and misunderstandings.
Occult Acetabular Fracture in Elderly Patients
Authors: Guerado Enrique , Cano Juan Ramón , Cruz Encarnación 
Published: December 2012

Acetabular fractures in the elderly are increasingly common; however, an antecedent of trauma may not be known, and the diagnosis easily missed. Early identification and prompt management are needed in order to minimise morbidity rates, but little has been published on occult acetabular fracture.
In this paper we present three cases of occult acetabular fracture in patients older than 75 years. All three are females and had previously been operated on the ipsilateral hip with an implant (two proximal femur fractures treated with a proximal intramedullary femoral nail, and one case of total joint replacement); these acetabular fractures could be related to the existence of a stress shielding mechanism.
We believe that whenever an elderly patient feels groin pain, and anteroposterior pelvis X-rays are normal, oblique Judet projections (obturator and iliac) should be obtained. In any case, displacement will make any fracture evident within a few weeks.
Droit de vote des étrangers, l'Arlésienne
Authors: Andrès Hervé 
Published: December 2012

Au nombre des droits civiques, il en est un dont l’exercice reste interdit aux étrangers : le droit de vote. Il fait l’objet récurrent de projets et propositions de loi, sans qu’aucun gouvernement n’ait jamais eu le courage de transformer l’essai. Les justifications ne manquent pas, qui sont toujours les mêmes. Au point que l’on peut s’interroger sur la signification réelle d’une telle inertie.
Transfer of Plancherel Measures for Unitary Supercuspidal Representations betweenp-adic Inner Forms
Authors: Choiy Kwangho 
Published: December 2012

AbstractLetFbe ap-adic field of characteristic 0, and letMbe anF-Levi subgroup of a connected reductiveF-split group such thatGLnifor positive integersrand ni. We prove that the Plancherel measure for any unitary supercuspidal representation ofM(F) is identically transferred underthe local Jacquet–Langlands type correspondencebetweenMand itsF-inner forms, assuming a working hypothesis that Plancherel measures are invariant on a certain set. This work extends the result of Muić and Savin (2000) for Siegel Levi subgroups of the groups SO4nand Sp4nunderthe local Jacquet–Langlands correspondence. It can be applied to a simply connected simpleF-group of typeE6orE7, and a connected reductiveF-group of typeAn,Bn,CnorDn.
Total Factor Productivity and the Bio Economy Effects
Authors: Zuniga Gonzalez Carlos Alberto 
Published: December 2012

This paper develops a new measure of total factor productivity growth in agricultural Production which incorporates Bio Economic components effects.The new measure is called the Bio Economic-Oriented Total Factor Productivity (BTFP) index, and incorporates components of Bio Economic as liquid biofuels. BTFP measure changes in Bio Economic efficiency and can be decomposed into bio economy efficiency change (BEC), and Bio Economic technological change (BTC) components.An empirical analysis, involving 7 Central American countries-level during 1980-2007, is provided using DEA methods. The results have shown a positive annual growth in bio economy total factor productivity of 1.1 percent. This change is explained by 0.03 percent per year in the bio economy efficiency change (or bio economy catch-up) and bio economy technical change (or bio ethanol frontier-shift) is providing 0.09 percent.
α‐Adrenoceptor Assays
Authors: Abel Peter W. , Jain Neha 
Published: December 2012

Abstractα‐Adrenoceptors mediate responses to activation of both peripheral sympathetic nerves and central noradrenergic neurons. They also serve as autoreceptors that modulate the release of norepinephrine (NE) and other neurotransmitters. There are two major classes of α‐adrenoceptors, the α1‐ and α2. Each class is subdivided into three subtypes: α1A, α1B, α1D, and α2A, α2B, α2C. Described in this unit are in vitro isolated tissue methods used to study α‐adrenoceptor functions and to identify novel ligands for these receptors. Detailed protocols describing use of isolated tissues to study the various α1‐ and α2‐adrenoceptor subtypes are provided. Curr. Protoc. Pharmacol. 59:4.5.1‐4.5.32. © 2012 by John Wiley & Sons, Inc.
Inventory Record Inaccuracy in Retail Supply Chains
Authors: DeHoratius Nicole 
Published: December 2012

Abstract
Inventory record inaccuracy (IRI), defined as the discrepancy between the recorded inventory quantity and the actual inventory quantity physically available on the shelf, is a substantial problem in retailing. This article summarizes the research documenting the problem of IRI within retail supply chains and reviews several potential solutions to IRI offered by operations management researchers. In addition, this article explores how execution problems within retail distribution centers contribute to store‐level IRI. Through direct observations and interviews with retail employees, we identify numerous errors that occur within the retail distribution center and how such errors create a mismatch between actual and recorded store inventory. We argue that it is critical to detect, determine the root cause of, and correct such errors in an effort to prevent them from cascading from one stage of the distribution process to the next. We claim error prevention in distribution, similar to quality improvement in manufacturing, requires improving workforce practices, fool proofing operational processes, and appropriate incentive design. We conclude with our recommendations for further study on this topic.
The
A
ssociation of
A
sia
P
acific
O
perational
R
esearch
S
ocieties
Authors: Yuan Yaxiang , Liu Degang 
Published: December 2012

Abstract
The Association of Asia Pacific Operational Research Societies, abbreviated as APORS, is one of the regional groupings under the International Federation of Operational Research Societies (IFORS). Its objectives are to develop operational research (OR) as a unified science and advance it in the Asia‐Pacific nations through sponsoring international meetings, exchanging information on OR, encouraging AP nations to establish their national societies, and promoting OR education and applications. By 2011, APORS has 12 member societies and becomes actively involved in all IFORS activities.
Modeling composite emulsion polymerization kinetics
Authors: de Wet‐Roos D. , Knoetze J. H. 
Published: December 2012

AbstractThe conversion profiles of a number of factorial designed experiments used to study composite emulsion polymerization were modeled using a deterministic mathematical construct as well as an empirical neural network approach. In the deterministic modeling approach, existing mechanistic models for emulsion polymerization were employed for which estimates of rate constants were obtained from established literature sources as well as experiments. Fitting of the kinetic data was done using nonlinear fitting algorithms to adjust the estimated rate constants to provide the best fit of the conversion profiles. In the case of the empirical modeling using neural networks, the neural net inputs were in the form of the factor levels of the various experimental designs. Several nonrelated experimental designs could be combined in this way to serve as the input, whereas the conversion profiles were targeted as outputs. Following the successful implementation of both modeling strategies, a hybrid modeling approach was tested by combining the neural network predictive power to estimate values for rate constants while retaining the aforementioned mechanistic models to fit the data. © 2012 Wiley Periodicals, Inc. Int J Chem Kinet 45: 101–117, 2013
Understanding the dynamics behind photoisomerization of light‐driven molecular rotary motors
Authors: Filatov Michael 
Published: December 2012

AbstractThe design and synthesis of artificial molecular motors to power up the nanoscale mechanical devices is one of the urgent tasks for modern synthetic chemistry. Light‐driven molecular rotary motors are a key class of compounds that undergo unidirectional rotation about a double bond through a series of photochemical and thermal steps. To improve their functionality and to develop new design strategies, a deeper understanding of the dynamics behind light‐driven rotary motion is required. Such an understanding can be only gained from the accurate dynamics simulations of the nonadiabatic photo‐rearrangement processes occurring during the motor operation. The currently available methods of quantum chemistry combined with the nonadiabatic molecular dynamics techniques represent a powerful tool for the investigation of the dynamic aspects of the molecular motors functionality. The results obtained in theoretical simulations provide for an unprecedented understanding of the photoisomerization process and hold considerable implications in achieving improved design strategies for future generations of molecular motors. © 2012 John Wiley & Sons, Ltd.This article is categorized under:

Structure and Mechanism > Molecular Structures
The Use of Lipids and Fatty Acids to Measure the Trophic Plasticity of the Coral Stylophora subseriata
Authors: Seemann J. , Sawall Y. , Auel H. , Richter C. 
Published: December 2012

AbstractFollowing up on previous investigations on the stress resistance of corals, this study assessed the trophic plasticity of the coral Stylophora subseriata in the Spermonde Archipelago (Indonesia) along an eutrophication gradient. Trophic plasticity was assessed in terms of lipid content and fatty acid composition in the holobiont relative to its plankton (50–300 μm) food as well as the zooxanthellae density, lipid, FA and chlorophyll a content. A cross‐transplantation experiment was carried out for 1.5 months in order to assess the trophic potential of corals. Corals, which live in the eutrophied nearshore area showed higher zooxanthellae and chlorophyll a values and higher amounts of the dinoflagellate biomarker FA 18:4n‐3. Their lipid contents were maintained at similar to levels from specimens further away from the anthropogenic impact source going up to 14.9 ± 0.9 %. A similarity percentage analysis of the groups holobiont, zooxanthellae and plankton >55 μm found that differences between the FA composition of the holobiont and zooxanthellae symbionts were more distinct in the site closer to the shore, thus heterotrophic feeding became more important. Transplanted corals attained very similar zooxanthellae, chlorophyll a and lipid values at all sites as the specimens originating from those sites, which indicates a high potential for trophic plasticity in the case of a change in food sources, which makes this species competitive and resistant to eutrophication.
Institutional prevention policies and rates of Group B Streptococcus infection among HIV‐infected pregnant women and their infants in Latin America
Authors: Joao Esaú , Gouvea Maria I. , Freimanis‐Hance Laura , Cohen Rachel A. , Read Jennifer S. , Melo Victor , Duarte Geraldo , Ivalo Silvina , Machado Daisy M. , Pilotto Jose , Siberry George K. 
Published: December 2012

AbstractObjectiveTo describe Group B Streptococcus (GBS) prevention policies at 12 Latin American sites participating in the NICHD (Eunice Kennedy Shriver National Institute of Child Health and Human Development) International Site Development Initiative (NISDI) Longitudinal Study in Latin American Countries (LILAC) and to determine rates of rectovaginal colonization and GBS‐related disease among HIV‐infected pregnant women and their infants.MethodsSite surveys were used to assess prevention policies and practices administered cross‐sectionally during 2010. Data collected in NISDI from 2008 to 2010 regarding HIV‐infected pregnant women were used to determine rates of colonization and GBS‐related disease.ResultsOf the 9 sites with a GBS prevention policy, 7 performed routine rectovaginal screening for GBS. Of the 401 women included in the NISDI study, 56.9% were at sites that screened. The GBS colonization rate was 8.3% (19/228 women; 95% confidence interval [CI], 5.1%–12.7%). Disease related to GBS occurred in 0.5% of the participants (2/401 women; 95% CI, 0.1%–1.8%); however, no GBS‐related disease was reported among the 398 infants (95% CI, 0.0%–0.9%).ConclusionImproved efforts to implement prevention policies and continued surveillance for GBS are needed to understand the impact of GBS among HIV‐infected pregnant women and their infants in Latin America.
Distributions of Pore Water Pressure Surround a Horizontal Drain Pipe on a Retaining wall Under Steady State Condition
Authors: Chen C. N. , Chen H. Y. 
Published: December 2012

AbstractThis article presents the results from a study of drainage rates and groundwater pressure distributions surrounding a horizontal drain pipe. The pipe is assumed to be applied on a retaining wall and reached a steady state condition. The optimized design pattern for horizontal drain pipes on a retaining wall is deeply related to the efficiency of dissipation of groundwater and the pore pressure behind the wall. Therefore, simulations of groundwater flow through a single horizontal drain pipe with different sizes (diameters and lengths) and depths by a 3-D finite element program model would lead us to find out the mechanism of the drainage pattern. The study has revealed the equalized water pressure contours surrounding the horizontal drain pipe exhibited horn shapes distributions. The biggest but still has a closed shape of horn was named Characterized Iso-pressure Surface (CIPS) in this research. It was found to be a good object to reflect the effects of single drain pipe so as to explore the mechanisms of drainage pattern. This research conducted a series study of dimension factor influence. It could be a help in developing assessment and design methods for horizontal drain pipes applied to the retaining wall.
Flow Induced Aerodynamic Noise Analysis of Perforated Tube Mufflers
Authors: Wang C.-N. , Tse C.-C. , Chen S.-C. 
Published: December 2012

AbstractDespite the analysis of muffler performance for many years, most works focus mainly on reducing inlet sound and fail to consider the flow effect. Most of their results correlate well with the experimental measurements. Subsequent works have considered the mean flow effect. Owing to Doppler's effect, transmission loss curve of the muffler will shift in its corresponding frequency. However, the correlation is worse than the experimental results since the flow induced noise does not include in the analysis. This work elucidates how flow induced noise affects muffler performance by analyzing a uniform flow that passes through perforated mufflers. The flow field is calculated with the CFD method, followed by evaluation of the aerodynamic noise based on the simulation results. Additionally, the procedure is simplified by computing and comparing only the total sound power induced by the flow in the muffler interior. Two muffler types, Helmholtz resonator and plug perforated tube muffler, are analyzed and discussed.