bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ion Channels and Transporters in Cancer: Pathophysiology, Regulation, and Clinical Potential
Authors: Pedersen Stine Falsig , Stock Christian 
Published: January 2013

Abstract
Over the last 15 years it has become increasingly clear that dysregulated expression, splicing, and/or function of ion channels and transporters (ICT) occur in all cancers. Being linked to the widely accepted hallmarks of cancer, ICTs represent novel therapeutic, diagnostic, and prognostic targets. To discuss the current status of the field, a colloquium on “Ion Transport and Cancer” was held, covering the roles of ICTs in cancer cell proliferation, apoptosis, motility, and invasion, and in both the generation of and the interaction of the cancer cells with the tumor environment. Additional sessions dealt with pancreatic ductal adenocarcinoma and transport protein–based therapeutic and diagnostic concepts. There was overall consensus that essential contributions of ICT dysregulation to the cancer process have been demonstrated. Future research should be directed toward further elucidating the mechanisms and developing therapeutic applications. Cancer Res; 73(6); 1658–61. ©2012 AACR.
Borrowing Information across Subgroups in Phase II Trials: Is It Useful?
Authors: Freidlin Boris , Korn Edward L. 
Published: January 2013

AbstractBecause of the heterogeneity of human tumors, cancer patient populations are usually composed of multiple subgroups with different molecular and/or histologic characteristics. In screening new anticancer agents, there might be a scientific rationale to expect some degree of similarity in clinical activity across the subgroups. This poses a challenge to the design of phase II trials assessing clinical activity: Conducting an independent evaluation in each subgroup requires considerable time and resources, whereas a pooled evaluation that completely ignores patient heterogeneity can miss treatments that are only active in some subgroups. It has been suggested that approaches that borrow information across subgroups can improve efficiency in this setting. In particular, the hierarchical Bayesian approach putatively uses the outcome data to decide whether borrowing of information is appropriate. We evaluated potential benefits of the hierarchical Bayesian approach (using models suggested previously) and a simpler pooling approach by simulations. In the phase II setting, the hierarchical Bayesian approach is shown not to work well in the simulations considered, as there appears to be insufficient information in the outcome data to determine whether borrowing across subgroups is appropriate. When there is strong rationale for expecting a uniform level of activity across the subgroups, approaches using simple pooling of information across subgroups may be useful. Clin Cancer Res; 19(6); 1326–34. ©2012 AACR.
Topotecan and Doxorubicin Combination to Treat Recurrent Ovarian Cancer: The Influence of Drug Exposure Time and Delivery Systems to Achieve Optimum Therapeutic Activity
Authors: Patankar Nilesh A. , Pritchard Julia , van Grinsven Mariska , Osooly Maryam , Bally Marcel B. 
Published: January 2013

Abstract
Purpose: To provide proof-of-concept data to support use of Doxil–liposomal topotecan (Topophore C) combinations to treat ovarian cancer.
Experimental Design: ES-2, OVCAR-3, and SKOV-3 ovarian cancer cell lines were treated with doxorubicin–topotecan combinations by exposing the cells to drugs from 1 to 72 hours. Pharmacokinetic analysis was conducted following administration of liposomal formulations of these drugs alone and in combination. Efficacy assessments were completed in ES-2 and SKOV-3 ovarian cancer models.
Results: On the basis of drug doses capable of achieving 50% reduction in cell viability over 72 hours, doxorubicin–topotecan combinations were additive in SKOV-3 but highly synergistic in ES-2 and OVCAR-3 cells. Favorable drug–drug interactions increased with increased drug exposure time. Topophore C pharmacokinetic remained unaffected when co-administered with Doxil. In the ES-2 model, Doxil at maximum tolerated dose (MTD 7.5 mg/kg) in combination with free topotecan (MTD 15 mg/kg) did not enhance median survival time (MST) over that achieved with topotecan alone. In contrast, MST was increased to 52 days with combination of Topophore C (MTD 2.5 mg/kg) and Doxil (7.5 mg/kg) compared with untreated animals (MST 18 days) or those treated with Topophore C alone (MTD 5 mg/kg, MST 40 days). In the SKOV-3 model, combination treatments showed better therapeutic efficacy than the individual drugs.
Conclusions: Topotecan–doxorubicin combinations produced additive or synergistic effects which were best achieved when the tumor cells were exposed to drugs over extended time. Doxil–Topophore C combinations are therapeutically superior as judged in two ovarian cancer models. Clin Cancer Res; 19(4); 865–77. ©2012 AACR.
Effects of Ginger Supplementation on Cell-Cycle Biomarkers in the Normal-Appearing Colonic Mucosa of Patients at Increased Risk for Colorectal Cancer: Results from a Pilot, Randomized, and Controlled Trial
Authors: Citronberg Jessica , Bostick Roberd , Ahearn Thomas , Turgeon D. Kim , Ruffin Mack T. , Djuric Zora , Sen Ananda , Brenner Dean E. , Zick Suzanna M. 
Published: January 2013

Abstract
To estimate the effects of ginger on apoptosis, proliferation, and differentiation in the normal-appearing colonic mucosa, we randomized 20 people at increased risk for colorectal cancer to 2.0 g of ginger or placebo daily for 28 days in a pilot trial. Overall expression and distributions of Bax, Bcl-2, p21, hTERT, and MIB-1 (Ki-67) in colorectal crypts in rectal mucosa biopsies were measured using automated immunohistochemistry and quantitative image analysis. Relative to placebo, Bax expression in the ginger group decreased 15.6% (P = 0.78) in the whole crypts, 6.6% (P = 0.95) in the upper 40% (differentiation zone) of crypts, and 21.7% (P = 0.67) in the lower 60% (proliferative zone) of crypts; however, there was a 19% increase (P = 0.14) in Bax expression in the upper 40% relative to the whole crypt. While p21 and Bcl-2 expression remained relatively unchanged, hTERT expression in the whole crypts decreased by 41.2% (P = 0.05); the estimated treatment effect on hTERT expression was larger in the upper 40% of crypts (−47.9%; P = 0.04). In the ginger group, MIB-1 expression decreased in the whole crypts, upper 40% of crypts, and lower 60% of crypts by 16.9% (P = 0.39), 46.8% (P = 0.39), and 15.3% (P = 0.41), respectively. These pilot study results suggest that ginger may reduce proliferation in the normal-appearing colorectal epithelium and increase apoptosis and differentiation relative to proliferation—especially in the differentiation zone of the crypts and support a larger study to further investigate these results. Cancer Prev Res; 6(4); 271–81. ©2012 AACR.
The Blurry Line Between Humans and Gods
Authors: Segal Robert A. 
Published: January 2013

Abstract
The conventional view is that at least in the West there is a clear-cut and insurmountable divide between human beings and God. This article argues that the divide is neither clear-cut nor insurmountable. Three disparate cases are considered: the conception of God in the Hebrew Bible, traditional and contemporary conceptions of heroism, and the status of celebrities.
A Different Cut? Comparing Attitudes toward Animals and Propensity for Aggression within Two Primary Industry Cohorts—Farmers and Meatworkers
Authors: Richards Emma , Signal Tania , Taylor Nik 
Published: January 2013

Abstract
Previous research has examined a range of demographic variables that have been shown to influence an individual’s attitude toward, and in turn their treatment of, animals. Little is known, however, about the effect of certain occupations upon these attitudes. The current study examines attitudes toward animals and the propensity for aggression within a sample of farmers and meatworkers in Queensland, Australia. Recent findings and publicity around the effects of employment (and cases of deliberate animal cruelty) within these industries indicates that this is an area in need of investigation from both human and animal welfare perspectives. The implications of the current findings for the meat-working industry and for the field of human-animal studies are discussed.
Bullies, Victims, and Animal Abusers: Do They Exhibit Similar Behavioral Difficulties?
Authors: Sanders Cheryl E. , Henry Bill C. , Giuliani Christine N. , Dimmer Lisa N. 
Published: January 2013

Abstract
Two hundred forty-four male undergraduate students enrolled in an introductory psychology class completed surveys assessing animal abuse tendencies, bullying behaviors, and victimization by bullying during their K-12 school experience. Participants also completed the Strengths and Difficulties Questionnaire, which evaluated their behavioral difficulties. Results revealed a significant relationship between animal abuse and bullying and victimization experiences. Moreover, animal abusers, bullies, and victims of bullying displayed significantly more behavioral problems when compared to nonabusers, nonbullies, and nonvictims. Multivariate analysis revealed a complex pattern of main effects for animal abuse, bullying, and victimization on the SDQ subscales. In addition, a three-way interaction between animal abuse, bullying, and victimization was identified for the SDQ Conduct Problems subscale. These results can be utilized to help identify areas of psychological functioning that may be of concern for this population.
The tribe Dysoniini part II: The genus Markia (Orthoptera: Tettigoniidae; Phaneropterinae), new species and some clarifications
Authors: CADENA-CASTAÑEDA OSCAR J. 
Published: January 2013

This paper clarifies the status of the species of the genus Markia White, 1862, also providing new distribution data. It describes M. erinaceus from Peru, M. arizae n.sp. from the Amazonian foothills of Colombia and Ecuador, M. sarriai n.sp. from the Colombian Biogeographic Chocó, M. espinachi n.sp. from Costa Rica; as well as the true male of M. major (Brunner von Wattenwyl, 1878), clarifying the real distributional range this latter species. M. longivertex n. syn., is proposed as a synonym of M. major. The colour polymorphism in M. hystrix (Westwood, 1844) is discussed and its distribution range is defined. A key to the species of Markia is provided.
First female description of Glyphonotus sinensis Uvarov, 1939 (Orthoptera: Tettigoniidae: Tettigoniinae) from China
Authors: LIU CHUN-XIANG 
Published: January 2013

First description of the female of Glyphonotus sinensis from China is provided. Detailed characteristics of head, pronotum, leg spination, wings, and female abdominal apex are given. Important and necessary illustrations of female of the species are presented.
Fasciotomy and Surgical Tenotomy for Recalcitrant Lateral Elbow Tendinopathy
Authors: Koh Joyce S.B. , Mohan P.C. , Howe T.S. , Lee Brian P. , Chia S.L. , Yang Zixian , Morrey Bernard F. 
Published: January 2013

Background: The optimal choice for intervention for recalcitrant lateral elbow tendinopathy remains unclear as various treatment modalities have documented comparable results in the literature. Purpose: To explore the safety, tolerability, and early efficacy of a new minimally invasive mode of treatment that delivers focused, calibrated ultrasonic energy, effectively microresecting the pathological tendon and removing only pathological tissue. Study Design: Case series; Level of evidence, 4. Methods: Seven male and 13 female patients aged 33 to 65 years averaging 12.5 months (range, 4-48) of failed nonoperative therapy underwent the ultrasonic microresection procedure in an outpatient clinic setting. The procedure involved a sterile, ultrasound-guided percutaneous microresection with a proprietary device (TX1) performed through a stab incision under local anesthesia. The duration of the procedure and complications of the device or procedure were assessed. Outcome parameters included patient satisfaction; visual analog scale (VAS) pain scores; Disabilities of the Arm, Shoulder and Hand (DASH) scores at 1, 3, 6, and 12 months; and ultrasound assessment at 3 and 6 months. Results: The median duration for the sterile confirmatory ultrasound examination (phase 1) was 88.5 seconds (range, 39-211; SD, ±47.6), the median duration of the procedure proper (phase 2) was 10.1 minutes (range, 4.1-19.4; SD, ±3.7), and the median energy time (duration the TX1 device was activated) was 32.5 seconds (range, 18-58; SD, ±11.0). No complications were encountered. A significant improvement in VAS score (from 5.5 to 3.3; P < .001) occurred by 1 week, and significant improvements in both DASH-Compulsory (from 21.7 to 11.3; P = .001) and DASH-Work (from 25.0 to 6.3; P = .012) scores occurred by 1 month. The VAS scores further improved at 3, 6, and 12 months (from 2.0 to 1.0 to 0.50; P = .003 and .023). The DASH-Compulsory score improved significantly from 3 to 6 months (from 8.6 to 4.6; P = .003), and both the DASH-Compulsory and DASH-Work scores were sustained by 12 months. Sonographically reduced tendon thickness (19 patients), resolved or reduced hypervascularity (17 patients), and reduced hypoechoic area (18 patients) occurred by 6 months. Nineteen of the 20 patients (95%) expressed satisfaction with the procedure, with 9 patients being very satisfied with their overall experience at 6 months after the procedure, 10 patients somewhat satisfied, and 1 patient neutral. Conclusion: Ultrasonic microresection of diseased tissue with the TX1 device provides a focally directed, safe, specific, minimally invasive, and well-tolerated treatment for recalcitrant lateral elbow tendinopathy in an office-based or ambulatory surgical setting with good evidence of some level of efficacy in 19 of 20 patients (95%) that is sustained for at least 1 year.
Cumulative Incidence of ACL Reconstruction After ACL Injury in Adults
Authors: Collins Jamie E. , Katz Jeffrey N. , Donnell-Fink Laurel A. , Martin Scott D. , Losina Elena 
Published: January 2013

Background: Anterior cruciate ligament (ACL) injuries are common and potentially disabling and frequently prompt surgical reconstruction. The utilization of ACL reconstruction among ACL-injured patients has not been examined rigorously. Purpose: This study reports the 3-year cumulative incidence of ACL reconstruction among adults with ACL injury and compares demographic and clinical characteristics of ACL-injured patients who do and do not go on to undergo ACL reconstruction. Study Design: Cohort study; Level of evidence, 3. Methods: A tertiary health care system patient data repository was used to identify patients diagnosed with an ACL injury between January 1, 2001, and December 31, 2007. Follow-up data were obtained to determine how many patients with ACL injury underwent ACL reconstruction within 3 years of ACL injury diagnosis. Stratified analyses were used to examine incidence rates separately by sex, age, race, primary language, socioeconomic status (SES), and health insurance status. Multivariable logistic regression models were built to examine the association of patient characteristics with utilization of ACL reconstruction. Results: There were 2304 patients, with a mean age of 47 years, diagnosed with an ACL injury between 2001 and 2007. The 3-year cumulative incidence of ACL reconstruction after ACL injury diagnosis was 22.6% (95% CI, 20.9%-24.3%). Eighty-six percent of patients undergoing reconstruction did so within 6 months of injury diagnosis, while 94% underwent reconstruction within 1 year. In multivariable models, several patient features were independently associated with a higher adjusted odds of undergoing ACL reconstruction, including male sex (adjusted odds ratio [aOR], 1.4; 95% CI, 1.1-1.7), younger age (aOR per decade, 1.8; 95% CI, 1.7-2.0), white race (aOR, 1.4; 95% CI, 0.94-1.9), higher SES (aOR, 1.4; 95% CI, 1.04-1.8 for high vs low SES; aOR, 1.3; 95% CI, 1.02-1.8 for medium vs low SES), and private health insurance versus self-pay (aOR, 1.9; 95% CI, 1.04-3.5). Conclusion: Less than a quarter of patients with a diagnosed ACL injury underwent ACL reconstruction in the 3 years after diagnosis. The odds of having surgery were higher for men, whites, younger patients, patients with higher SES, and patients with private health insurance.
The effects of participating in creative activities on the health and well-being of children and young people: a rapid review of the literature
Authors: Bungay Hilary , Vella-Burrows Trish 
Published: January 2013

Aims: Health-promoting strategies need to be culturally appropriate to encourage healthy behaviours and lifestyle choices in children and young people. This rapid review explores the effects of participating in creative activities on the health and well-being of children aged between 11 and 18 years. Methods: Building on an earlier systematic review undertaken by Daykin and colleagues1 a rapid review of the literature published between 2004 and 2011 was undertaken. The search was conducted systematically and included research on music, dance, singing, drama and visual arts, taking place in community settings or as extracurricular activities in mainstream schools. Therapies such as art, drama and music were excluded from the review. Results: Following rigorous application of inclusion and exclusion criteria, 20 papers were included in the review: six quantitative, eight qualitative and six mixed-method approaches. The interventions used in the studies were diverse and the research was heterogeneous, therefore overall synthesis of the results was inappropriate. The review is therefore organised into the following headings: sexual health, obesity, mental health and emotional well-being. Despite the methodological weakness and limitations of the majority of the studies there were some consistencies in their findings. It was found that participating in creative activities can have a positive effect on behavioural changes, self-confidence, self-esteem, levels of knowledge and physical activity. Conclusions: Although the research evidence is generally weak there is some evidence that using creative activities as part of a health-promoting strategy may be a useful method of increasing knowledge and positive behaviours in children and young people.
Eudaimonic well-being and community arts participation
Authors: Swindells Rachel , Lawthom Rebecca , Rowley Kevin , Siddiquee Asiya , Kilroy Amanda , Kagan Carolyn 
Published: January 2013

Aims: This article considers eudaimonic models of psychological well-being in relation to qualitative data previously gathered as part of Manchester Metropolitan University’s Invest to Save Arts in Health programme (2004–07). Methods: The research draws from 21 interviews with participants involved in Invest to Save arts projects for older people and adults with a mental health diagnosis. Using a collaborative team approach, a hybrid thematic analysis was undertaken alongside an updated literature review framed by positive psychology and with a focus on well-being. Results: The analysis identified eudaimonic themes of autonomy/intrinsic motivation and challenge to be particularly pertinent to participants’ experiences of the scheme. Findings suggest that the programme provided a sense of purposeful occupation, cognitive and creative challenge and opportunities for autonomous self-expression and heightened concentration (flow). Many participants identified with the arts activities on offer and, while not necessarily aspiring to achieve any particular status, were intrinsically motivated to develop what they considered to be their innate creative potential. Some also reported that sustained engagement was important to their continued psychological well-being. Conclusions: Arts and health researchers might usefully draw from theories of well-being from positive psychology. Both fields are compatible in that they share an interest in human flourishing and understanding of wellness as more than an absence of dysfunction or disease. Further research is needed to ascertain whether the limited results presented here are representative of other populations. What does seem evident is that arts projects have a broad appeal and can be highly inclusive, accommodating participants with diverse needs. More generally the investigation raises questions about the cultural scaffolds that are in place to support eudaimonic well-being across the lifespan, as well as the consequences of restricting such opportunities for individuals and communities.
Active music making: a route to enhanced subjective well-being among older people
Authors: Creech Andrea , Hallam Susan , Varvarigou Maria , McQueen Hilary , Gaunt Helena 
Published: January 2013

Aims: This research explored the relationship between active music making and subjective well-being, in older people’s lives. The research focused on how participation in making music might enhance older people’s social, emotional and cognitive well-being, through meeting the basic psychological needs identified in earlier research. Method: The research comprised three case studies, each offering a variety of musical activities to older people. In each case study a sample of older people were asked to complete questionnaires and psychological needs scales related to autonomy, competence, relatedness and self-realisation before and after a substantial period of active engagement with music. Results: Principal components analysis (PCA) of responses to the CASP-121 and the Basic Needs Satisfaction scale2 revealed three factors: purpose (having a positive outlook on life; autonomy and control; and social affirmation (positive social relationships, competence and a sense of recognised accomplishment). Comparisons of those engaged in music making with those participating in other activities revealed statistically significant differences on all three factors with the music groups giving more positive responses. Conclusions: The enhanced subjective well-being found among participants in music may have been due to the potential for music to provide a sense of purpose through progression in music and creative expression. Control and autonomy may be supported by the holistic nature of musical engagement, whereby meeting new musical challenges involves physical and cognitive engagement. Finally, social affirmation may be supported through social interaction; giving and receiving peer support; and performance, which confers status, a sense of giving something back to the community, pride and opportunities for positive reinforcement. Further research needs to identify the mechanisms through which music is able to achieve these effects.