bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma
Authors: Jary Marine , Vernerey Dewi , Lecomte Thierry , Dobi Erion , Ghiringhelli François , Monnien Franck , Godet Yann , Kim Stefano , Bouché Olivier , Fratte Serge , Gonçalves Anthony , Leger Julie , Queiroz Lise , Adotevi Olivier , Bonnetain Franck , Borg Christophe 
Published: January 2015

Abstract
Background: Baseline prognostic biomarkers stratifying treatment strategies in first-line metastatic colorectal cancer (mCRC) are lacking. Angiopoietin-2 (Ang-2) is proposed as a potential biomarker in several cancers. We therefore decided to establish the additional prognostic value of Ang-2 for overall survival (OS) in patients with first-line mCRC.
Methods: We enrolled 177 patients treated with a bevacizumab containing chemotherapy in two prospective phase II clinical trials. Patient plasma samples were collected at baseline. ELISAs were used to measure Ang-2.
Results: The multivariable Cox model identified increased lactate dehydrogenase [HR, 1.60; 95% confidence interval (CI), 1.04–2.45; P = 0.03] and Ang-2 log-transformation level (HR, 1.59; 95% CI, 1.14–2.21; P = 0.0065) as two significant independent OS prognostic factors. It exhibited good calibration (P = 0.8) and discrimination (C-index: 0.64; 95% CI, 0.58–0.68). Ang-2 parameter inclusion in the GERCOR reference model significantly and strongly improved its discriminative ability because the C-statistic increased significantly from 0.61 to 0.63 (bootstrap mean difference = 0.07; 95% CI, 0.069–0.077). Interestingly, the addition of Ang-2 binary information with a 5 ng/mL cutoff value to the GERCOR model allowed the reclassification of intermediate-risk profile patients (41%) into two subsets of low and high risks.
Conclusions: Our study provides robust evidence in favor of baseline Ang-2 prognostic value for OS adding to the conventional factors. Its assessment appears to be useful for the improvement in risk stratification for patients with intermediate-risk profile.
Impact: Ang-2 ability to predict OS at diagnosis could be of interest in the selection of patients eligible for intermittent or sequential therapeutic strategies dedicated to the optimization of patients' quality of life and chemotherapy cost-effectiveness. Cancer Epidemiol Biomarkers Prev; 24(3); 603–12. ©2015 AACR.
Kwestie i spory religijne na terenie Rusi Zakarpackiej w czechosłowackim epizodzie jej dziejów
Authors: Jarnecki Michał , Palinczak Mykoła 
Published: January 2015

The issues and religious disputes in Carpathian Ruthenia in Czechoslovak period and its echoes behind the AtlanticIn Subcarpathian Ruthenia in the interwar period – during her membership in Czechoslovakia, one of the sharper conflict was a dispute between two Christian churches. In fact, the rivalry of the two churches began even earlier, during the Hungarian reign – before 1918, but broke out with the new intensity in the interwar period. The Czech authorities, retained neutrality in the confessional disputes, unlike its predecessors, favoring the units. The dispute also had political significance – namely in the conflict between national orientations: Russophile and Ukrainian. Both churches were not monoliths and shook them as internal tensions, including politically motivated ones. Religious conflicts had also their roots and echoes on the other side of the Atlantic. Part of the Greek-Catholic immigrants Transcarpathian did not want to submit to the American Catholic hierarchy, who failed to see the specifics of this group of emigrants. During the period between the Uniate Church recorded outflow faithful to the Orthodox Church, by almost 5% (from nearly 55% to 50.2%) and Orthodox increase by approximately the same proportion – over 15% of the population. Kwestie i spory religijne na terenie Rusi Zakarpackiej w czechosłowackim epizodzie jej dziejówNa Rusi Zakarpackiej w okresie międzywojennym, podczas jej przynależności do Czechosłowacji, jednym z ostrzejszych konfliktów był spór pomiędzy dwoma chrześcijańskimi Kościołami. Faktycznie rywalizacja dwóch Kościołów zaczęła się wcześniej, za rządów węgierskich – przed 1918 rokiem, ale rozgorzała z nową intensywnością w okresie międzywojennym, kiedy władze czeskie, zachowywały neutralność w tych konfesyjnych sporach, w przeciwieństwie od poprzedników, faworyzujących unitów. Spór miał także aspekt polityczny – ocierając się o konflikt między orientacjami narodowymi: ukraińską i rosyjską. Oba Kościoły nie były monolitami i wstrząsały nimi także wewnętrzne napięcia, w tym na tle politycznym. Konflikty na tle religijnym miały też swoje zaoceaniczne korzenie i echa, gdzie część grekokatolickich emigrantów zakarpackich nie chciała się podporządkować amerykańskiej hierarchii katolickiej, nie dostrzegającej specyfiki tej grupy wychodźców. Podczas okresu międzywojennego Kościół unicki odnotował odpływ wiernych na rzecz prawosławia, o prawie 5% (z prawie 55 do 50,2%), a Cerkiew Prawosławna przyrost o mniej więcej o ten sam odsetek – do ponad 15% mieszkańców.
O roli polskiej muzyki w kształtowaniu tożsamości narodowej
Authors: Zaniewicz Joanna Ewa 
Published: January 2015

On the influence of Polish music on national identityThe article deals with the role of patriotic songs in shaping national identity of the Polish. The discourse is divided into three matters. The first part is introductory and treats about the most essential issues and research problems, regarding the key topic. I attempt to answer the raised questions in the last part of the work. The middle part of a historical character presents crucial research assumptions, along with all the transformations that have taken place over the years, and have been influencing our comprehending of national songs and strengthening the feeling of national identity. The final part sums the discourse up and is critical to the key topic. I strive to foresee possible consequences of the described phenomena. I derive my conclusions from the analysis, presented in the second part of the article, and from my personal experience, which has been gained due to long years of participating and organizing patriotic concerts and performances. O roli polskiej muzyki w kształtowaniu tożsamości narodowejW poniższym artykule zajmuję się rozważaniami na temat współczesnej roli pieśni patriotycznej w kształtowaniu tożsamości narodowej Polaków. Artykuł został podzielony na trzy części. Pierwsza z nich ma charakter wprowadzający i przedstawia najważniejsze problemy badawcze dotyczące tematu. Druga część ma charakter historyczny, przedstawia najistotniejsze założenia badaczy oraz przemiany na przestrzeni lat naszego rozumienia znaczenia pieśni patriotycznych w kształtowaniu i umacnianiu polskiej tożsamości narodowej. Ostatnia część stanowi próbę przewidzenia przyszłych następstw analizowanego problemu. Przedstawione wnioski opierają się na analizie oraz obserwacjach własnych wynikających z wielu lat uczestniczenia, organizowania i tworzenia koncertów o charakterze patriotycznym.
Thalamic lesions in multiple sclerosis by 7T MRI: Clinical implications and relationship to cortical pathology
Authors: Harrison Daniel M , Oh Jiwon , Roy Snehashis , Wood Emily T , Whetstone Anna , Seigo Michaela A , Jones Craig K , Pham Dzung , van Zijl Peter , Reich Daniel S , Calabresi Peter A 
Published: January 2015

Objective: Pathology in both cortex and deep gray matter contribute to disability in multiple sclerosis (MS). We used the increased signal-to-noise ratio of 7-tesla (7T) MRI to visualize small lesions within the thalamus and to relate this to clinical information and cortical lesions. Methods: We obtained 7T MRI scans on 34 MS cases and 15 healthy volunteers. Thalamic lesion number and volume were related to demographic data, clinical disability measures, and lesions in cortical gray matter. Results: Thalamic lesions were found in 24/34 of MS cases. Two lesion subtypes were noted: discrete, ovoid lesions, and more diffuse lesional areas lining the periventricular surface. The number of thalamic lesions was greater in progressive MS compared to relapsing–remitting (mean ±SD, 10.7 ±0.7 vs. 3.0 ±0.7, respectively, p < 0.001). Thalamic lesion burden (count and volume) correlated with EDSS score and measures of cortical lesion burden, but not with white matter lesion burden or white matter volume. Conclusions: Using 7T MRI allows identification of thalamic lesions in MS, which are associated with disability, progressive disease, and cortical lesions. Thalamic lesion analysis may be a simpler, more rapid estimate of overall gray matter lesion burden in MS.
The incidence and prevalence of psychiatric disorders in multiple sclerosis: A systematic review
Authors: Marrie Ruth Ann , Reingold Stephen , Cohen Jeffrey , Stuve Olaf , Trojano Maria , Sorensen Per Soelberg , Cutter Gary , Reider Nadia 
Published: January 2015

Background: Psychiatric comorbidity is associated with lower quality of life, more fatigue, and reduced adherence to disease-modifying therapy in multiple sclerosis (MS). Objectives: The objectives of this review are to estimate the incidence and prevalence of selected comorbid psychiatric disorders in MS and evaluate the quality of included studies. Methods: We searched the PubMed, PsychInfo, SCOPUS, and Web of Knowledge databases and reference lists of retrieved articles. Abstracts were screened for relevance by two independent reviewers, followed by full-text review. Data were abstracted by one reviewer, and verified by a second reviewer. Study quality was evaluated using a standardized tool. For population-based studies we assessed heterogeneity quantitatively using the I2 statistic, and conducted meta-analyses. Results: We included 118 studies in this review. Among population-based studies, the prevalence of anxiety was 21.9% (95% CI: 8.76%–35.0%), while it was 14.8% for alcohol abuse, 5.83% for bipolar disorder, 23.7% (95% CI: 17.4%–30.0%) for depression, 2.5% for substance abuse, and 4.3% (95% CI: 0%–10.3%) for psychosis. Conclusion: This review confirms that psychiatric comorbidity, particularly depression and anxiety, is common in MS. However, the incidence of psychiatric comorbidity remains understudied. Future comparisons across studies would be enhanced by developing a consistent approach to measuring psychiatric comorbidity, and reporting of age-, sex-, and ethnicity-specific estimates.
Fingolimod does not impair T-cell release from the thymus and beneficially affects Treg function in patients with multiple sclerosis
Authors: Haas Jürgen , Schwarz Alexander , Korporal-Kunke Mirjam , Jarius Sven , Wiendl Heinz , Kieseier Bernd C , Wildemann Brigitte 
Published: January 2015

Background: In multiple sclerosis (MS), disturbed T-cell homeostasis affects both conventional CD4+ T cells (Tcon) and regulatory T cells (Treg). Functionally, this is linked to a loss of Treg-suppressive properties. Concerns exist as to whether fingolimod might further aggravate Treg dysfunction by inhibiting thymic egress and, thus, promoting premature immunosenescence. Objective: The objective of this paper is to investigate whether fingolimod, by sequestration of developing cells in the thymus, might deteriorate numeric and/or functional disequilibrium of T-cell subtypes. Methods: We assessed numbers and phenotypes of blood Tcon and Treg in 74 MS patients treated with fingolimod and in 37 healthy donors. Treg and Tcon were also analyzed for immunoreactivity, suppressive function, sphingosine-1-phosphate-triggered (S1P) trafficking, and S1P-receptor expression. This was complemented by assessing surrogate markers of thymic T-cell development, including frequencies of cells expressing T-cell receptors (TCR) of dual specificity, and TCR diversity in Treg. Results: Fingolimod did not negatively affect naive T-cell phenotypes or markers of thymic T-cell development. By reducing CCR7-expressing Tcon, fingolimod increased relative proportions of Treg. As a result of this shift, fewer proliferative CCR7− Tcon became enriched and Treg-dysfunction was indirectly reversed. Conclusion: These observations argue against harmful interference of fingolimod with thymic T-cell output that, particularly in pediatric MS, might possibly counteract its beneficial effects.
Analysis of genes, pathways and networks involved in disease severity and age at onset in primary-progressive multiple sclerosis
Authors: Giacalone G , Clarelli F , Osiceanu AM , Guaschino C , Brambilla P , Sorosina M , Liberatore G , Zauli A , Esposito F , Rodegher M , Ghezzi A , Galimberti D , Patti F , Barizzone N , Guerini F , Martinelli V , Leone M , Comi G , D’Alfonso S , Martinelli Boneschi F 
Published: January 2015

Background: The role of genetic factors in influencing the clinical expression of multiple sclerosis (MS) is unclear. Objective: The objective of this paper is to identify genes, pathways and networks implicated in age at onset (AAO) and severity, measured using the Multiple Sclerosis Severity Score (MSSS), of primary-progressive MS (PPMS). Methods: We conducted a genome-wide association study (GWAS) of 470 PPMS patients of Italian origin:. Allelic association of 296,589 SNPs with AAO and MSSS was calculated. Pathway and network analyses were also conducted using different tools. Results: No single association signal exceeded genome-wide significance in AAO and MSSS analyses. Nominally associated genes to AAO and MSSS were enriched in both traits for 10 pathways, including: “oxidative phosphorylation” (FDRAAO=9*10−4; FDRMSSS=3.0*10−2), “citrate (TCA) cycle” (FDRAAO=1.6*10−2; FDRMSSS=3.2*10−3), and “B cell receptor signaling” (FDRAAO=3.1*10−2; FDRMSSS=2.2*10−3). In addition, an enrichment of “chemokine signaling pathway” (FDR=9*10−4) for AAO and of “leukocyte transendothelial migration” (FDR=2.4*10−3) for MSSS trait was observed, among others. Network analysis revealed that p53 and CREB1 were central hubs for AAO and MSSS traits, respectively. Conclusions: Despite the fact that no major effect signals emerged in the present GWAS, our data suggest that genetic variants acting in the context of oxidative stress and immune dysfunction could modulate the onset and severity of PPMS.
Family Hardships and Serum Cotinine in Children With Asthma
Authors: Spanier Adam J. , Beck Andrew F. , Huang Bin , McGrady Meghan E. , Drotar Dennis D. , Peake Roy W. A. , Kellogg Mark D. , Kahn Robert S. 
Published: January 2015

BACKGROUND AND OBJECTIVE:A better understanding of how poverty-related hardships affect child health could highlight remediable intervention targets. Tobacco smoke exposure may be 1 such consequence of family hardship. Our objective was to explore the relationship between family hardships and tobacco exposure, as measured by serum cotinine, a tobacco metabolite, among children hospitalized for asthma.METHODS:We prospectively enrolled a cohort of 774 children, aged 1 to 16 years, admitted for asthma or bronchodilator-responsive wheezing. The primary outcome was detectable serum cotinine. We assessed family hardships, including 11 financial and social variables, through a survey of the child’s caregiver. We used logistic regression to evaluate associations between family hardship and detectable cotinine.RESULTS:We had complete study data for 675 children; 57% were African American, and 74% were enrolled in Medicaid. In total, 56% of children had detectable cotinine. More than 80% of families reported ≥1 hardship, and 41% reported ≥4 hardships. Greater numbers of hardships were associated with greater odds of having detectable cotinine. Compared with children in families with no hardships, those in families with ≥4 hardships had 3.7-fold (95% confidence interval, 2.0–7.0) greater odds of having detectable serum cotinine in adjusted analyses. Lower parental income and educational attainment were also independently associated with detectable serum cotinine.CONCLUSIONS:Family hardships are prevalent and associated with detectable serum cotinine level among children with asthma. Family hardships and tobacco smoke exposure may be possible targets for interventions to reduce health disparities.
Strain induced super-paramagnetism in Cr2O3 in the ultra thin film limit
Authors: Tanabe Iori , Kazi Haseeb , Cao Yuan , Rodenburg Jack L , Komesu Takashi , Dong Bin , Pasquale Frank L , Sky Driver M. , Kelber Jeffry A , Dowben Peter A 
Published: January 2015

ABSTRACTUltra thin films of chromia (Cr2O3), less than 3 nm thick, grown epitaxial on α-Al2O3 (sapphire), and are thus compressively strained in-plane. The resulting films show evidence of some magnetic ordering above the Néel temperature of chromia (307 K). The observed higher temperature hysteresis effect observed are very likely a strain effect, and not associated with the typical antiferromagnetic ordering expected of chromia.
Adsorption and Flow of Multiple Tracers in Porous Media
Authors: Deem Richard L. , Ali S.M. Farouq 
Published: January 2015

Abstract
It is common practice to employ radioactive tracers for studying fluid movement in oil reservoirs. In many instances, excessive tracer adsorption and anomalous tracer flow behaviour have been reported. The present investigation was concerned with the phenomena associated with the flow of fluids containing radioactive tracers (tritium and Carbon-14). Miscible displacements were conducted in order to evaluate tracer retention and/or adsorption effects. A suitable counting and efficiency determination technique was developed in order to evaluate the radioactivities of fluid systems containing two radioisotopes. The use of two radioactive tracers to trace the simultaneous flow of two fluids was found to be a very effective tool.
The adsorption of tritium during miscible displacements conducted in Berea sandstone cores averaged 1.5 per cent. A systematic investigation showed that this adsorption could be explained on the basis of the exchange of tritium atoms with the hydrogen atoms of the water of hydration found in naturally-occurring clays in porous media.
It was found that the adsorption of tritium increased with a decrease in the displacement rate.
No adsorption of Carbon-14 was observed in miscible displacements in sandstone cores. An average of 0.47 per cent tracer retention was observed during desorption displacements involving Carbon-14, but such retention is attributed to mass transfer effects, and is not considered a true adsorption phenomenon.
A technique for determining the counting efficiency of multiply-tagged fluids was developed. The quenching and scintillating effects of a salt, a hydrocarbon and an alcohol were investigated. It was found that liquid scintillation instrument counting efficiency corrections only partially compensate for extraneous quenching or scintillation effects.
The Data Required for Properly Sizing Gas Well Surface Equipment
Authors: Younger H. 
Published: January 2015

Abstract
A review of the data required for properly sizing gas well surface equipment (dehydrators and heaters) is made. The need and effect of each piece of data is outlined. A slightly modified method of setting the design flow rate is proposed.

Introduction
Most gas in reservoirs is at high pressures and is considered to be saturated with water. Upon its being brought to the surface, it is reduced in pressure and thus temperature; this causes the water of saturation to condense. Also, the gas generally needs purification before it is sold as a commercial fuel. This is generally done in a centralized processing plant, so the gas from the well has to be transported to the central plant.
A strange antiferromagnetic phase has controlled the magnetic and paleomagnetic properties of the Fe-Ti inversion spinel bearing rocks on the whole Earth globe
Authors: Orlický Oto 
Published: January 2015

Abstract
The magnetic characteristics of Fe and Fe-Ti magnetic mineral bearing rocks of young, through recent, quaternary, mesozoic to palaeozoic age have been studied. I have discovered a strange antiferromagnetic phase (AFMP) in Fe and Fe-Ti magnetic minerals of about 288 samples from 78 localities of volcanic rocks and of about 346 samples of the sedimentary rocks. The AFM phase has played a very important role in magnetism and paleomagnetism of rocks. I have considered that an evolution of the AFM phase started probably after solidification of magnetic minerals during post magmatic process and it has gradually followed during survival of minerals on the Earth’s surface. The AFMP can be found in different evolutional stages, from a begining stage to completely developed stage. The indicated AFMP has the Néel temperature (TN), in the range from 350°C to 485°C, mostly around 450° C in the samples under study. I have deduced that one can find the rocks in the two basically different aggregations: 1) The rocks containing so called the pseudo original phase state magnetic minerals, where the AFM phase is absent, and 2) The rocks containing the transformed phase state magnetic minerals, where the AFM phase is present. The AFM phase coexists with the ferrimagnetic phases in large range of temperatures and disappears at TN. The AFM phase has a strong relations with magnetic properties, including the polarity of RM of rocks. The rocks with a copletely develped AFM phase have always reversed RM. The AFM phase bearing rocks have possessed lower values of magnetic susceptibility (κ) comparing them with the Fe and Fe-Ti minerals bearing rocks, where the AFMP is absent. The self-reversed partial thermoremanent magnetization (PTRM) was induced in many samples of volcanic rocks, applying a normally oriented geomagnetic field in the laboratory. In all these rocks was present the AFM phase. The rocks without the AFM phase have always normal RM. I can propose that the reversed RM of the AFMP containing magnetic minerals bearing rocks has been generated by the self-reversal process in nature
Laboratory and image spectroscopy for evaluating the biophysical state of meadow vegetation in the Krkonoše National Park
Authors: Jelének Jan , Kupková Lucie , Zagajewski Bogdan , Březina Stanislav , Ochytra Adrian , Marcinkowska Adriana 
Published: January 2015

Abstract
The paper deals with the evaluation of mountain meadow vegetation condition using in-situ measurements of the fraction of Accumulated Photosynthetically Active Radiation (fAPAR) and Leaf Area Index (LAI). The study analyses the relationship between these parameters and spectral properties of meadow vegetation and selected invasive species with the goal of finding out vegetation indices for the detection of fAPAR and LAI. The developed vegetation indices were applied on hyperspectral data from an APEX (Airborne Prism Experiment) sensor in the area of interest in the Krkonoše National Park. The results of index development on the level of the field data were quite good. The maximal sensitivity expressed by the coefficient of determination for LAI was R2 = 0.56 and R2 = 0.79 for fAPAR. However, the sensitivity of all the indices developed at the image level was quite low. The output values of in-situ measurements confirmed the condition of invasive species as better than that of the valuable original meadow vegetation, which is a serious problem for national park management.
The Electronic Spatial Information System – tools for the monitoring of asbestos in Poland
Authors: Krówczyńska Małgorzata , Wilk Ewa , Zagajewski Bogdan 
Published: January 2015

Abstract
On January 1, 2005 the use of asbestos-containing products was banned in the European Union. According to the Act of 19 June 1997 banning the use of these products, their usage in Poland should be abated by the end of 2032. The whole process is being monitored by the Electronic Spatial Information System for the Monitoring of Asbestos Products Removal. The system design was based on a geodatabase. The research area of the study is the whole territory of Poland at the national, provincial and local level of detail. The monitoring process embraces spatial analysis through the preparation and interpretation of a range of maps. The results obtained from the deployed methods proved that the system has been useful for decision making purposes during the monitoring process. The proposed solutions were appreciated by the EU.