bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative genomic and immunopathologic analysis of lung adenocarcinomas with and without cytology‐proven malignant pleural effusions
Authors: Pineda Cristiana M. , Majid Adnan , Costa Daniel B. , VanderLaan Paul A. 
Published: August 2024

AbstractBackgroundLung cancer complicated by malignant pleural effusions (MPEs) is associated with significantly increased morbidity and mortality, yet the mechanisms of MPE development remain poorly understood. This study sought to elucidate whether there were specific genomic alterations and/or immunologic biomarkers associated with the presence of MPEs.MethodsAnalysis of comprehensive genomic and immunologic profiling for 275 locally advanced (stage III) or advanced (stage IV) lung adenocarcinomas was subcategorized into cytology‐confirmed MPE‐positive (MPE+; n = 139 stage IV) and MPE‐negative (MPE−; n = 30 stage III + n = 106 stage IV) groups.ResultsSmoking frequency (p = .0001) and tumor mutational burden (p < .001) were demonstrated to be lower in the MPE+ group compared to the MPE− group. Median overall survival in the MPE+ group was shorter than in the MPE− group across all data (2.0 vs. 5.5 years; p < .0001) and for smokers (1.2 vs. 6.4 years; p < .0001). There were a number of differences at the genomic level across all cases and when stratifying by smoking status, including a higher frequency of EGFR mutations and a lower frequency of STK11 mutations in the MPE+ cohort. Finally, investigation of the comutational profiles of tumors by MPE status revealed differences in TP53‐ and STK11‐mutant tumors between the two groups.ConclusionsOverall, these findings imply that there are both clinical and genetic factors associated with advanced lung adenocarcinoma MPEs. Future studies of these alterations may prove important both for understanding the pathophysiology of MPE development in advanced cancer and for the earlier detection of at‐risk patients.
Quality of Life After Orthognathic Surgery in Swedish Patients: A Register‐Based Cohort
Authors: Johansson Eric , Lund Bodil , Bengtsson Martin , Magnusson Mikael , Rasmusson Lars , Ahl Magnus , Sunzel Bo , Sjöström Mats 
Published: August 2024

ABSTRACTObjectiveThis study aimed to evaluate the effect of orthognathic surgery on quality of life among Swedish patients.Materials and MethodsPatients subjected to orthognathic surgery due to dentofacial deformity (DFD) and registered in the National Register of Orthognathic Surgery (NROK) in Sweden between 2017 and 2020 were eligible for inclusion in this study. The Swedish‐validated Orthognathic Quality of Life Questionnaire (S‐OQLQ) was used to evaluate patient quality of life before and after surgery. The S‐OQLQ measured each patient's subjective experience regarding social aspects.ResultsEighty‐four participants were included in this cohort study, including 45 men (mean age 24.7 years), 48 women (mean age 23.4 years), and eight patients who stated no gender. Women generally graded several aspects of the S‐OQLQ higher than men, including facial aesthetics p = 0.029), oral function (p < 0.001), and awareness of facial deformity (p = 0.0054). For all domains of the questionnaire (social, facial aesthetics, function, and awareness), a significant improvement was seen 6–24 months after surgery (p < 0.001). Women rated improvement of function and awareness of facial deformity higher than men (p < 0.001 and p = 0.039, respectively).ConclusionQuality of life aspects of orthognathic surgery have a strong impact on the treatment outcome. Although functional impairment is often considered a major indication for surgery, the social and aesthetic influence of DFD is highly rated by patients, whereas pain is not an issue before or after treatment.
Hydroxy‐Carboxylic Acids as Green and Abundant Ligands for Sustainable Recovery of Copper from a Multimetallic Powder: A Proof of Concept
Authors: Ostellari Pietro , Tapparelli Martina , Bragaggia Giulia , Sandon Annalisa , Lavagnolo Maria Cristina , Girardi Leonardo , Manica Michele , Salmaso Luigi , Gross Silvia 
Published: August 2024

AbstractThe recovery of copper and other valuable metals had become increasingly strategic for the future of the global economy, particularly in regions lacking abundant mineral resources, such as most European countries. In this study, we investigated the viability of utilizing environmentally friendly, cost‐effective, abundant and bio‐based ligands, specifically carboxylic acids and their derivatives, for copper leaching in a low‐temperature hydrometallurgical process. Our investigation focused on elucidating the impact of substituents in the α position of hydroxy‐carboxylic acids on copper solubilization efficacy. Notably, hydroxy‐carboxylic acids, like malic acid and lactic acid, were evidenced as particularly promising ligands for leaching copper from a custom‐made multimetallic powder. By thoroughly characterizing the obtained complexes (Raman, UV‐Vis) and by supporting the experimental efforts by a Design of Experiment (DoE) approach, we optimized the leaching process. The influence of experimental parameters such as pH, temperature, leaching time, and Cu/ligand molar ratio on process yield (determined through Inductively Coupled Plasma – Optical Emission Spectroscopy, ICP‐OES, analysis) was thoroughly investigated. Additionally, we developed a subsequent copper recovery step by precipitating copper (II) hydroxide in an alkaline environment, guided by speciation diagrams tailored for each copper‐ligand system.
A systematic review exploring the variation in the compositional make‐up and phytochemical constituents of wheatgrass and pulse microgreens as a function of diverse growing condition
Authors: Kumar Arun , Singh Narpinder 
Published: August 2024

AbstractThe wheatgrass and pulse microgreens have gained popularity for their concentrated phytochemical content. However, the variability in growth parameters and compositional constituents of wheatgrass and pulse microgreens is dependent on the prevailing environmental conditions. Nowadays, wheatgrass and pulse microgreens are used as culinary sources or incorporated into various food products and consumed by a large proportion of the global population. Therefore, it is necessary to review the impact of growth conditions to meet the increased demand. This will allow breeders to adjust their cultivation techniques according to consumer preferences for specific nutritional components. This systematic review seeks to provide an analysis of the available literature on the variation in growth and compositions of wheatgrass and pulse microgreens as the influence of diverse growing conditions. The growth of wheatgrass and pulse microgreens can be influenced by a range of growth conditions, such as variations in light intensity, temperature, nutrient availability, and cultivation techniques. The variation in growth and compositional components, in terms of proximate composition and certain constituents such as chlorophyll, antioxidants, minerals, phenolic compounds, and secondary metabolites, is discussed in relation to the changing cultivation parameters as published in recent studies. However, this review only covers the compositional make‐up of wheatgrass and pulse microgreens. There remains a need to summarize the compositional profiles of other microgreen species under various conditions. Ultimately, this review illuminates the promise of emerging superfoods and underscores how their growth and composition can vary depending on cultivation methods, ultimately impacting their capacity to promote health. In addition, there is a need to establish dose–response relationships to address various diseases. Therefore, additional research may be warranted.
Association of ventricular–arterial coupling with biomarkers involved in heart failure pathophysiology – the STANISLAS cohort
Authors: Holm Hannes , Magnusson Martin , Jujić Amra , Lagrange Jérémy , Bozec Erwan , Lamiral Zohra , Bresso Emmanuel , Huttin Olivier , Baudry Guillaume , Monzo Luca , Rossignol Patrick , Zannad Faiez , Girerd Nicolas 
Published: August 2024

AimsImpaired left ventricular–arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF). The extent of the relationship between VAC and circulating biomarkers associated with HF has been scarcely documented. We aimed to explore associations of VAC with proteins involved in HF pathophysiology within a large population‐based cohort of middle‐aged individuals.Methods and resultsIn the forth visit of the STANISLAS family cohort, involving 1309 participants (mean age 48 ± 14 years; 48% male) from parent and children generations, we analysed the association of 32 HF‐related proteins with non‐invasively assessed VAC using pulse wave velocity (PWV)/global longitudinal strain (GLS) and arterial elastance (Ea)/ventricular end‐systolic elastance (Ees). Among the 32 tested proteins, fatty acid‐binding protein adipocyte 4, interleukin‐6, growth differentiation factor 15, matrix metalloproteinase (MMP)‐1, and MMP‐9 and adrenomedullin were positively associated with PWV/GLS whereas transforming growth factor beta receptor type 3, MMP‐2 and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) were negatively associated. In multivariable models, only MMP‐2 and NT‐proBNP were significantly and inversely associated with PWV/GLS in the whole population and in the parent generation. Higher levels of NT‐proBNP were also negatively associated with Ea/Ees in the whole cohort but this association did not persist in the parent subgroup.ConclusionElevated MMP‐2 and NT‐proBNP levels correlate with better VAC (lower PWV/GLS), possibly indicating a compensatory cardiovascular response to regulate left ventricular pressure amidst cardiac remodelling and overload.
Varying the Electronics on Isothiourea Catalysts: Basicity, Rate, and Selectivity
Authors: J. Harrison Christian , D. Dickerson Shelby , Gong Ziyuan , S. McGowan Amanda , Vista Jane , L. Wiskur Sheryl 
Published: August 2024

AbstractChiral and achiral substituted isothiourea catalysts were synthesized and employed in model silylation reactions to understand how changing the electronics on the catalyst core affected intermolecular interactions between catalyst intermediates and substrates, ultimately affecting selectivity and rate. Five different chiral catalysts were utilized in a silylation‐based kinetic resolution of 2‐(para substituted)phenylcyclohexanols and the rate of silylation of these same alcohols was investigated with three different achiral catalysts. Linear free energy relationships were examined, highlighting that rate and selectivity were highly dependent on the electronics of the catalyst and the substrate, and that both affected the intermolecular interactions that resulted.
Individuals' willingness to pay for HIV vaccines in Iran: Contingent valuation method
Authors: Parvizi Sanaz , Mehrara Mohsen , Taiebnia Ali 
Published: August 2024

AbstractBackground and AimsThis study aims to assess individuals' willingness to pay (WTP) for a human immunodeficiency virus (HIV) vaccine in Iran, focusing on key determinants influencing vaccine acceptance. Utilizing the contingent valuation method (CVM), we aim to provide insights into the economic and socio‐cultural factors shaping WTP in Iran.MethodsWe conducted face‐to‐face surveys with 468 participants in Tehran province using purposive sampling. We analyzed demographic characteristics, perspectives on HIV/AIDS, and financial considerations alongside participants' WTP. Statistical analyses, including maximum likelihood estimation, identified factors influencing WTP. Mean WTP values were calculated to quantify the economic valuation of an HIV vaccine.ResultsHigher education and monthly income significantly correlated with increased WTP, while gender, age, marital status, and health insurance showed no substantial impact. The mean WTP was 12,590.83 to 12,599.63 thousand Rials in different models, both showing statistically significant WTP values.ConclusionHigher education and income levels are key determinants of WTP for an HIV vaccine in Iran. These findings provide valuable insights for policymakers to enhance vaccine accessibility and acceptance in Iran.
On the psychological effects of child‐like space design on preschoolers under anesthesia: A qualitative study
Authors: Zhou Zhiguo , Hu Chunming , Zhang Yalin , Zhang Peng 
Published: August 2024

AbstractBackground and AimsIn this study, a pediatric hospital was selected as the study setting, to investigate the effects of the environment of a pediatric operating room child‐friendly space on preschool children under anesthesia.MethodsInterviews were conducted in pediatric hospitals through anesthesia of preschool children. This study randomizing children between the ages of 1 and 7 years (seven males, five females, mean age 3.8 years, standard deviation 0.7). Twelve participants took part in this interview, which was an in‐depth interview of preschoolers' perceptions of anesthesia using generalized data analysis to assess young children's perceived preferences and sensitivity to the environment. Preschoolers' preferences for feeling under anesthesia are reflected in four main areas.Results(1) Interesting and engaging environment. (2) Humanized design, free of fear and unfamiliarity. (3) Caring, patient, and compassionate care by healthcare professionals. (4) High cooperation of the child and good doctor–patient relationship.ConclusionThe key findings of this study may help designers and clinicians to design a toddler‐friendly built environment where pediatric hospital child‐friendly spaces are designed to benefit their health and maximize their cooperation and psychological recovery.
STU3Net: An Improved U‐Net With Swin Transformer Fusion for Thyroid Nodule Segmentation
Authors: Deng Xiangyu , Dang Zhiyan , Pan Lihao 
Published: August 2024

ABSTRACTThyroid nodules are a common endocrine system disorder for which accurate ultrasound image segmentation is important for evaluation and diagnosis, as well as a critical step in computer‐aided diagnostic systems. However, the accuracy and consistency of segmentation remains a challenging task due to the presence of scattering noise, low contrast and resolution in ultrasound images. Therefore, we propose a deep learning‐based CAD (computer‐aided diagnosis) method, STU3Net in this paper, aiming at automatic segmentation of thyroid nodules. The method employs a modified Swin Transformer combined with a CNN encoder, which is capable of extracting morphological features and edge details of thyroid nodules in ultrasound images. In decoding through the features for image reconstruction, we introduce a modified three‐layer U‐Net network with cross‐layer connectivity to further enhance image reduction. This cross‐layer connectivity enhances the network's capture and representation of the contained image feature information by creating skip connections between different layers and merging the detailed information of the shallow network with the abstract information of the deeper network. Through comparison experiments with current mainstream deep learning methods on the TN3K and BUSI datasets, we validate the superiority of the STU3Net method in thyroid nodule segmentation performance. The experimental results show that STU3Net outperforms most of the mainstream models on the TN3K dataset, with Dice and IoU reaching 0.8368 and 0.7416, respectively, which are significantly better than other methods. The method demonstrates excellent performance on these datasets and provides radiologists with an effective auxiliary tool to accurately detect thyroid nodules in ultrasound images.
Cordycepin ameliorates kidney injury by inhibiting gasdermin D‐mediated pyroptosis of renal macrophages through nuclear factor kappa‐B
Authors: Tang Zhiling , Zhu Yu 
Published: August 2024

AbstractTo explain the effect and mechanism of cordycepin (COR) in resisting acute kidney injury (AKI). Network pharmacology was employed to analyze the correlations between COR, AKI, and pyroptosis, as well as the action target of COR. A mouse model of AKI was established by ischemia reperfusion injury (IRI), and after treatment with COR, the renal function, tissue inflammatory cytokine levels, and pyroptosis‐related signals were detected in mice. In in‐vitro experiments, damage of renal macrophages was caused by the oxygen‐glucose deprivation model, and pyroptosis indicators and inflammatory cytokine levels were assayed after COR treatment. Network pharmacological analysis revealed that nuclear factor kappa‐B (NF‐κB) was the primary action target of COR and that COR could inhibit kidney injury and tissue inflammation during IRI by inhibiting NF‐κB‐mediated gasdermin D cleavage. When NF‐κB was inhibited, the effect of COR was weakened. COR in renal macrophages could inhibit pyroptosis and lower the levels of inflammatory cytokines, whose effect was associated with NF‐κB. Our study finds that COR can play an anti‐inflammatory role and inhibit the progression of AKI through the NF‐κB‐mediated pyroptosis, which represents its nephroprotective mechanism.
Risk predictive model for the development of hepatocellular carcinoma before initiating long‐term antiviral therapy in patients with chronic hepatitis B virus infection
Authors: Chen Junjie , Feng Tienan , Xu Qi , Yu Xiaoqi , Han Yue , Yu Demin , Gong Qiming , Xue Yuan , Zhang Xinxin 
Published: August 2024

AbstractIt is generally acknowledged that antiviral therapy can reduce the incidence of hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC), there remains a subset of patients with chronic HBV infection who develop HCC despite receiving antiviral treatment. This study aimed to develop a model capable of predicting the long‐term occurrence of HCC in patients with chronic HBV infection before initiating antiviral therapy. A total of 1450 patients with chronic HBV infection, who received initial antiviral therapy between April 2006 and March 2023 and completed long‐term follow‐ups, were nonselectively enrolled in this study. Least absolute shrinkage and selection operator (LASSO) and Cox regression analysis was used to construct the model. The results were validated in an external cohort (n = 210) and compared with existing models. The median follow‐up time for all patients was 60 months, with a maximum follow‐up time of 144 months, during which, 32 cases of HCC occurred. The nomogram model for predicting HCC based on GGT, AFP, cirrhosis, gender, age, and hepatitis B e antibody (TARGET‐HCC) was constructed, demonstrating a good predictive performance. In the derivation cohort, the C‐index was 0.906 (95% CI = 0.869–0.944), and in the validation cohort, it was 0.780 (95% CI = 0.673–0.886). Compared with existing models, TARGET‐HCC showed promising predictive performance. Additionally, the time‐dependent feature importance curve indicated that gender consistently remained the most stable predictor for HCC throughout the initial decade of antiviral therapy. This simple predictive model based on noninvasive clinical features can assist clinicians in identifying high‐risk patients with chronic HBV infection for HCC before the initiation of antiviral therapy.
New insights in the management of pseudomyxoma peritonei
Authors: Pastier Clément , De Hingh I. H. J. T. , Goéré Diane 
Published: August 2024

AbstractWhile a rare entity, peritoneal pseudomyxoma treatment evolves. Decision‐making criteria improve with imaging development and exploratory laparoscopy. Surgery remains at the core of the therapeutic strategy whatever disease progression. Complete cytoreduction plus hyperthermic intraperitoneal chemotherapy (HIPEC) is standard of care. Iterative cytoreduction or debulking is sometimes justified. Intraperitoneal chemotherapy modalities change with early postoperative HIPEC or pressurized intraperitoneal aerosol chemotherapy. Systemic or local treatment such as new chemo/immuno‐therapies or BromAc should improve outcomes. Expertise and multicentric cooperation are more than ever needed.
Enhancing nursing students' cultural awareness through Community of Inquiry‐guided online ‘Internationalization at Home’ strategies—An intervention study
Authors: Chan Siu Ling , Fung John Tai Chun , Takemura Naomi , Chau Pui Hing , Lee Jay Jung Jae , Choi Hye Ri , Wan Wai Hin , Withrow Harrison , Lin Chia‐Chin 
Published: August 2024

AbstractAimInternationalization at Home (IaH) strategies play an important role in nursing curricula to enhance nursing students' cultural awareness in the globalized world. The Community of Inquiry (CoI) is a theoretical framework for the optimal design of online learning environments to support critical inquiry and discourse among students and teachers. To optimise nursing students' online cultural awareness learning experiences, it was timely to develop online IaH strategies based on a sound theoretical model. This study aimed to examine the effectiveness of CoI‐guided online IaH strategies on enhancing the cultural awareness of nursing undergraduates who enrolled in a community nursing course.DesignThis was an interventional pre‐test post‐test study.MethodOne hundred and six nursing undergraduates who enrolled in the course participated in the study. The online IaH strategies were developed focusing on the interactions of teaching presence, cognitive presence and social presence of CoI framework and they were integrated into the course. A previously validated Cultural Awareness Scale was adopted for pre‐post evaluation. Higher scores indicate greater cultural awareness.ResultsThe results showed that there was a significantly higher total score of cultural awareness of participating students at post‐online IaH strategies. To be effective, aligning CoI‐guided online IaH strategies with course content, pedagogy and assessment was shown to be significant. The inclusion of technological elements in related strategies was also critical to engage student learning. The positive change on the total score of cultural awareness suggested the effectiveness of the deployed strategies. In this ever‐changing educational landscape, it may provide insights to educators regarding considering online IaH strategies with theoretical underpinning for curriculum planning and design.