bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence of depression, anxiety, and sleep disturbances among medical students and resident physicians in Iran: A systematic review and meta-analysis
Authors: Shafiee Arman , Teymouri Athar Mohammad Mobin , Seighali Niloofar , Amini Mohammad Javad , Hajishah Hamed , Arabazadeh Bahri Razman , Akhoundi Amirhossein , Beiky Maryam , Sarvipour Nastaran , Maleki Saba , Zandifar Atefeh , Bakhtiyari Mahmood 
Published: August 2024

Background
We sought to conduct this comprehensive systematic review and meta-analysis to assess the prevalence of depression, anxiety, and sleep disturbance in Iranian medical students and resident physicians.

Methods
A systematic search was conducted on 23 December 2023 in PubMed/MEDLINE, Web of Science, Scopus, and Iranian national databases. We pooled the prevalence of individual studies using the random effect model.

Results
Our systematic search showed 36 articles that meet the eligibility criteria. Most included studies were cross-sectional. The most used questionnaire to assess depression, anxiety, and sleep disturbance were Beck Depression Inventory (BDI), The Depression, Anxiety and Stress Scale—21 Items (DASS-21), and The Pittsburgh Sleep Quality Index (PSQI), respectively. The overall prevalence of depression, anxiety, and sleep disturbance among Iranian medical students were 43% (95%CI: 33%–53%%, I2 = 98%), 44% (95%CI: 31%–58%%, I2 = 99%), 48% (95%CI: 39%–56%%, I2 = 97%), respectively. The results of subgroup and meta-regression analyses showed questionnaires used and the place of the medical school were significantly associated with the prevalence of aforementioned outcomes. Funnel plot and Begg’s regression test did not show a significant source of funnel plot asymmetry for depression, anxiety, and sleep disturbance.

Conclusion
In conclusion, our study showed that nearly half of the medical students had some type of depression, anxiety, and sleep disturbance problems. To address this serious national public health issue, efficient preventive measures, routine screenings, and prompt interventions are required.
Endometriosis of the Colon and Pericolic Lymph Nodes Presenting as Cecal Volvulus
Authors: Lin Frank , Bahirwani Janak , Stoll Lisa , Kapoor Sarina 
Published: August 2024

ABSTRACT
Endometriosis, characterized by the ectopic implantation of endometrial tissue, typically involves pelvic structures but infrequently extends to extrapelvic sites such as the gastrointestinal tract. In this report, we present a case of a 44-year-old woman with diffuse abdominal discomfort and constipation. Computed tomography imaging revealed a mass in the cecum, leading to diagnostic colonoscopy and subsequent magnetic resonance imaging. Ultimately, laparoscopy revealed a puckered cecal mass suspected to be invasive malignancy but pathologically confirmed as extensive endometriosis involving the colonic wall and pericolic lymph nodes. Cecal volvulus secondary to endometriosis is exceedingly rare, with surgical intervention being the primary treatment modality. Endometriosis-associated gastrointestinal involvement often masquerades as irritable bowel syndrome, highlighting the importance of considering atypical presentations in young women. This case underscores the need to maintain a high index of suspicion for unusual etiologies in patients with gastrointestinal symptoms and atypical imaging findings to facilitate timely diagnosis and management.
Gastrointestinal Alpha Heavy Chain Disease With Persistent Campylobacter Jejuni Colonization and Refractory Giardiasis
Authors: Tang Wei , Lin Zilan , Sharma Pritika , Heering Gabriel , Dworkin Brad , Steinberg Amir , Shakil Fouzia , Schorr-Lesnick Beth 
Published: August 2024

ABSTRACT
Alpha heavy chain disease (αHCD) is a rare variant of the mucosa-associated lymphoid tissue lymphoma characterized by expression of a monotypic truncated immunoglobulin α heavy chain. αHCD frequently involves the gastrointestinal (GI) tract, and its pathogenesis has been linked to clonal B-cell expansion from chronic immune stimulation by infectious agents. We report a rare case of GI αHCD with 5 concomitant pathogens identified on a GI multiplex real-time polymerase chain reaction panel, featured by persistent Campylobacter jejuni colonization and refractory giardiasis.
Efficacy and safety of Russian tableted rizatriptan 10 mg in the treatment of migraine attacks in clinical practice
Authors: Filatova E. G. , Latysheva N. V. , Kadymova N. B. , Berdnikova A. V. 
Published: August 2024

Triptans are a targeted therapy for acute migraine attacks. They are recommended for the treatment of severe attacks when non-specific analgesics are not effective. Four of the seven known triptans with different efficacy and individual tolerability are registered in the Russian Federation. Objective: to determine in an open-label non-comparative single center study efficacy and safety of the new Russian generic tableted rizatriptan 10 mg (Relonova) in real-life clinical practice. Material and methods. Thirty individuals with migraine took part in the study. Patients took rizatriptan to relieve 4 migraine attacks and filled out self-observation diaries and HIT-6 questionnaire before and after therapy. Results. The study involved 30 patients (26 women and 4 men) with mean age of 38.7 ± 9.3 years. Duration of migraine was 19.6 ± 11.4 years, mean number of days with migraine per month was 9.5 [5.25; 16.75]. Most patients (67 %) suffered from episodic migraine and 33 % from chronic migraine; 6 patients (20 %) had migraine attacks with aura; 20 individuals (67 %) received preventive therapy. After taking Relonova medication, pain relief was observed in 86 % of attacks, and in 45 % of cases pain disappeared completely; after 24 hours, pain relief was observed in 87 % of cases, and in 68 % – absence of attacks. A significant decrease in headache intensity was observed within 30 minutes after taking the first dose; in 34 % of attacks the headache returned. Additional analgesic treatment was required in 39 % of cases. Adverse events were observed in 25 % of attacks and were mild. The majority (63 %) of the participants were able to successfully terminate 3 attacks and were responders. Conclusion. Relonova is an effective and safe medication for the relief of migraine attacks.
Research progress of nanoparticles in diagnosis and treatment of hepatocellular carcinoma
Authors: Xing Lijun , Chen Yun , Zheng Tingting 
Published: August 2024

Abstract
Hepatocellular carcinoma (HCC) is among the most common malignant liver tumors. Despite progress in anticancer drugs and surgical approaches, early detection of HCC remains challenging, often leading to late-stage diagnosis where rapid disease progression precludes surgical intervention, leaving chemotherapy as the only option. However, the systemic toxicity, low bioavailability, and significant adverse effects of chemotherapy drugs often lead to resistance, rendering treatments ineffective for many patients. This article outlines how nanoparticles, following functional modification, offer high sensitivity, reduced drug toxicity, and extended duration of action, enabling precise targeting of drugs to HCC tissues. Combined with other therapeutic modalities and imaging techniques, this significantly enhances the diagnosis, treatment, and long-term prognosis of HCC. The advent of nanomedicine provides new methodologies and strategies for the precise diagnosis and integrated treatment of HCC.
IVDCheckR – simplifying documentation for laboratory developed tests according to IVDR requirements by introducing a new digital tool
Authors: Kaur Yadwinder , Rosenkranz Daniel , Bloemer Anna , Aykurt Ozan , Brandhorst Gunnar , Spitzenberger Folker , Petersmann Astrid 
Published: August 2024

Abstract

Objectives
A recent challenge for clinical laboratories is the lack of clear guidelines for handling significant modifications of CE-marked assays. The modifications may involve, for example, extending measurement intervals, changing dilution procedures or using non-validated sample materials. The challenge arises due to the amended Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR), which is now poised for implementation, despite the extended transition periods. The IVDR application imposes challenges not only for diagnostic companies but also for clinical laboratories when using laboratory developed tests (LDTs), often referred to as in-house assays. In this context, a coherent and meticulously structured LDT documentation is highly beneficial. While laboratories are obliged to meet the IVDR requirements, the absence of a streamlined framework or guideline hampers the ability to gain a comprehensive overview on the requirements and possible options for their fulfilment.

Methods
To address this issue, we introduce a web based digital tool powered by an R Shiny web application. This tool facilitates a seamless implementation of IVDR requirements for LDTs across diverse laboratory environments in terms of their transparency and validity. Our approach focuses on adequate handling of significant modifications of CE-marked in vitro diagnostic medical devices (IVD).

Results
IVDRCheckR is an open-source tool that is easily accessible and free from system dependencies. The tool promotes a seamless process and a guide to enhance transparency, reliability, and validity of laboratory examination results based on LDTs. Additionally, the tool further provides modules for evaluating quality control data and quantitative method comparison data.

Conclusions
Our Shiny web application-based platform is a digitised, user-friendly tool that simplifies the documentation for LDTs according to IVDR requirements with special emphasis on solutions for handling modifications to CE-marked assays.
In a Stranger’s House: Social Isolation of Internally Displaced People in Ukraine During Wartime
Authors: Tsybuliak Natalia , Popova Anastasiia , Lopatina Hanna , Suchikova Yana 
Published: August 2024

Abstract
This article explores the impact of internal displacement during wartime in Ukraine on individuals’ social isolation. This study focused on understanding and comparing feelings of isolation in two different contexts: the native community in territories temporarily occupied by Russian troops since the full-scale war and the host community. The research reveals a consistent pattern of isolation characterized by feelings of loneliness, anxiety, and emotional exhaustion among internally displaced people (IDPs), irrespective of their location. Cultural disconnection emerges as a significant factor in both settings, with war-induced changes in social norms and practices leading to a sense of alienation in native communities, and the challenge of adapting to new cultural environments in host communities. Furthermore, it highlights IDPs’ increased vulnerability to bias, stigma, and anxiety in social interactions. Overall, this qualitative study advances the understanding of the effects of displacement on social isolation and provides insights that can inform effective recovery strategies and foster a resilient, cohesive national identity in post-war contexts in Ukraine.
Exploiting the nanotechnological approaches for traditional Chinese medicine in childhood rhinitis: A review of future perspectives
Authors: Zhang Yao , Dong Haicheng , Zhu Yu , Wang Wenfei , Zhang Xinyue 
Published: August 2024

AbstractChildhood rhinitis is an inflammatory condition affecting the nasal mucosa of children worldwide. The physical, social, and cognitive performance of children is affected by the chronic symptoms of childhood rhinitis. Effective treatment is essential to avoid long-term effects on children’s lifestyles and well-being. Traditional Chinese medicine (TCM) has been used to treat and prevent several illnesses, and it plays a crucial role in healthcare and rehabilitation. TCM has traditionally been used to holistically treat rhinitis. However, the drawbacks of TCMs, such as their poor water solubility, low bioavailability, single-use, and poor targeting ability, severely restrict their use. In recent years, nanotechnology has been used for various drugs to improve their therapeutic effectiveness and reduce their associated adverse effects. Nanomaterials for TCM formulations are synthesized to be compatible with herbal extracts and sustain active component therapeutic qualities. Nanocarrier-based drug delivery improves bioavailability, circulation time, and targeted distribution, resolving TCM administration issues. This review assesses the innovative combination of TCM and nanotechnology developments for the treatment of childhood rhinitis, providing insights into novel therapeutic approaches. This review also provides significant insights into the potential of this multidisciplinary approach to transform treatment techniques in childhood rhinitis and offers a road map for future research initiatives in this promising sector.
Residual Flexural Capacity Prediction in Heat-Affected Concrete Members through Ground Penetrating Radar and Thermal Imaging
Authors: Quadir Upal Mohammad Towfiqul , Yazdani Nur , Beneberu Eyosias , Riad Mina 
Published: August 2024

Abstract
Extreme fire and related heat exposure that is attributable to natural or man-made events may cause significant damage to concrete members, with associated strength reduction. Rapid and effective on-site post-fire assessment is essential in estimating the associated damage and loss of load carrying capacity, leading to decisions on rehabilitation or replacement. Current knowledge on this subject considers a single nondestructive evaluation (NDE) technique and only qualitative estimations of the damage or destructive methods such as coring. This study fills this critical knowledge gap through the experimental utilization of ground penetrating radar (GPR) and thermography techniques on laboratory heat-affected concrete beam samples. Parameters such as concrete strength, heat level and duration, and presence of fireproofing, steel, and fiber reinforced polymer rebars were considered through experimental design. The thermal imaging method was found to be successful in a qualitative way as supplementary to the more reliable GPR approach. Predictive quantitative models with high reliability relating the parameters to the expected GPR output amplitude and residual flexural capacity of beam samples were developed. User-friendly and rapid in-situ post-fire NDEs of concrete flexural members were proposed based on the availability of information on the considered parameters from as-built plans or actual observations.
Maximizing the Utilization of the Treated RAP by a Two-Step Enhancement Method in Recycled Asphalt Mixtures
Authors: Zhang Jizhe , Zhang Wenwu , Xiao Yushuai , Hu Xueliang , Feng Zhengang , Kuang Dongliang , Yao Zhanyong 
Published: August 2024

Abstract
In a circular economy toward zero waste, reclaimed asphalt pavement (RAP) as a secondary resource into new asphalt pavement is one of the important waste management strategies for circularity. In view of the issues of low RAP usage and performance variation of recycled asphalt mixtures (RAM), this paper developed a two-step treatment method to enhance the properties of the coarse RAP as aggregates by removing old mortar and to restore the properties of old mortar/fine RAP by using a rejuvenating agent. First, the aged asphalt was extracted from RAP to evaluate its aging degree. The recycled asphalt mortar was prepared with fine RAP. The changes in surface morphology of recycled asphalt mortars were characterized by a computerized tomography scan, and the influence of the rejuvenating agent on the performance of recycled asphalt mortars was evaluated by a dynamic shear rheological test and a Bending Beam Rheometer test. Finally, RAM were prepared with 60 % of the treated RAP, and their properties were evaluated, including the water stability, low-temperature, and fatigue performance. Experimental results demonstrated that the rheological behavior and low-temperature performance of the recycled asphalt mortar can be effectively recovered by incorporating an appropriate rejuvenating agent with related parameters even better than that of the new asphalt mortar. Regarding RAM that incorporated a high dosage of the treated RAP, its pavement performance can be improved, and this proves the feasibility of using a high percentage of RAP in recycled asphalt pavements.
Calculation Method of Interface Contact Thermal Resistance between Rock and Lining in High Rock Temperature Tunnels Considering the Lithology
Authors: Cui Guangyao , He Ziyang , Wang Daoyuan 
Published: August 2024

Abstract
The disasters caused by the high rock temperature are increasingly prominent. To accurately assess the temperature at the rock-lining interface in high rock temperature tunnels, the rock thermal conductivity evaluation coefficient was introduced to propose a method for calculating interface contact thermal resistance that accounts for the influence of the surrounding rock lithology. This method, based on a disc model, offers precise insights into the thermal resistance between the surrounding rock and the tunnel lining. To validate the efficacy of this method, initial numerical simulations and subsequently performed laboratory experiments across various rock-concrete interfaces were conducted. Laboratory experiments reveal that the interface contact thermal resistance between rock and concrete specimens tends to decrease as temperatures rise from 20°C to 80°C. Moreover, a substantial increase in interfacial contact thermal resistance was observed when dealing with higher-grade surrounding rock (indicating lower quality), reaching up to 111.24 %. The maximum relative error observed in the results of the calculation method is 8.64 %, well within the acceptable range of 15 %, confirming its reliability and practicality for engineering applications. These research findings can serve as a valuable reference for designing support structures in high-temperature rock tunnels and advancing disaster prevention and mitigation technologies.
‘Fuck’ and emoticons
Authors: Flesch Marie 
Published: August 2024

This quantitative study investigates gender variation online by focusing on two ‘gendered’ linguistic variables: the swear word fuck, which has often been associated with men, and emoticons, which have been shown to be used more frequently by women than men. It is based on a nineteen-million-word gender-diverse corpus, which includes comments posted in English on the community website Reddit by 372 cisgender women, 372 cisgender men, 100 transgender women, 100 transgender men and 100 nonbinary individuals (all according to self-identification). The statistical analyses take both the gender and age of the Redditors into account. Results show that in most cases transgender men do not align with cisgender men; that transgender women mostly align with cisgender women in their use of fuck, but the former produce more emoticons than the latter, and that the use of the variables did not differ between nonbinary individuals assigned male versus female at birth.
‘Non-binary Gender Identities: The Language of Becoming’ Sebastian Cordoba (2023)
Authors: Nurfahmi Ardia Pramesti , Elian Yassar Muhammad Naufal , Wulandari Intan Kusuma 
Published: August 2024

Non-binary Gender Identities: The Language of BecomingSebastian Cordoba (2023) Routledge, 180 pp.
Thidiazuron Role in In vitro Flowering of Murraya paniculata and Fortunella hindsii via Embryogenic Protoplast and Hypocotyl Segments Cultures
Authors: Jumin Hasan Basri 
Published: August 2024

Background: Procedures to regenerate protoplast into plants of citrus relatives is important to establish the genetic improvement for sweet oranges by using somatic hybridization and transgenic. Protoplasts are a good material to genetically manipulate and to become gene transfer. This study aims to characterize the regeneration sequence of Fortunella hindsii and Murraya paniculata protoplasts via somatic embryogenesis into flowering plants in vitro. This study also describes the sequence of flowering in vitro originated from hypocotyl segments of plantlets of two species. Methods: Protoplast sources that were isolated from callus of Fortunella hindsii and Murraya paniculata. Embryogenic callus was put in Erlenmeyer and mixed together with 0.4% macerozyme, 0.2% cellulose and 0.1% driselase and pH was adjusted to 6.0. Two drops of purified protoplasts were cultured with media supplemented with 2.0% glucose and 0.0, 0.001, 0.01, 0.1 or 1.0. 10.0 mg/l thidiazuron (TDZ) and thicken with 0.9% gelrite. Result: The media supplemented with 0.001 mg/l TDZ yielded the maximum plating efficiency, while 0.001 mg/l TDZ produced the highest percentage of shoot formation, approximately 80%. After being cultured on the same TDZ concentration for 14 days, the protoplasts that survived developed cell walls. Fortunella hindsii and Murraya paniculata underwent somatic embryogenesis to grow into plantlets. Thidiazuron has demonstrated efficacy in forming flower buds that grow normally. Murraya paniculata and Fortunella hindsii shoots that emerged from hypocotyl segmments flowered in vitro on half-strength MT media containing 0.001 to 0.01 mg/l TDZ and 2-3% sucrose after two months of culture and they eventually went on to flower.
IMPLEMENTASI SISTEM INFORMASI MANAJEMEN ARSIP BERBASIS WEB PADA SURAT MASUK DAN KELUAR DI MAN 1 PASURUAN
Authors: Balqis Amelia 
Published: August 2024

Sistem pengelolaan arsip merupakan suatu hal yang harus diperhatikan dengan baik terkait dengan perannya yang sangat penting. Lembaga MAN 1 Pasuruan menerapkan sistem pengelolaan arsip berbasis web pada surat masuk dan keluar. Dimana dengan adanya sistem pengelolaan arsip berbasis web tersebut memberikan dampak dan perubahan yang signifikan dalam hal mengelola arsip. Sistem pengelolannya menjadikan arsip menjadi lebih efektif dan efisien.
Penelitian ini bertujuan untuk mengetahui urgensi sistem informasi manajemen arsip, mengetahui proses penerapan sistem informasi manajemen arsip berbasis web pada surat masuk dan keluar, dan mengetahui hasil dari implementasi sistem informasi manajemen arsip berbasis web tersebut.
Metode serta jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kualitatif deskriptif dimana di dalamnya terdapat tiga tahapan. Tahapan-tahapan tersebut diantaranya adalah pengumpulan data di lapangan, analisis data yang telah didapatkan, dan yang terakhir uji keabsahan data untuk mengkonfirmasi hasil dari data-data yang telah didapatkan.
Hasil penelitian yang didapatkan menunjukkan beberapa kesimpulan yaitu: (1) Arsip digunakan sebagai bukti dan sumber informasi sehingga MAN 1 Pasuruan memanfaatkan sistem pengelolaan arsip berbasis web untuk sistem pengelolaan arsip yang lebih bermanfaat; (2) Dalam penerapannya sistem informasi manajemen arsip berbasis web meliputi alur pengadaan surat, pengelompokan surat, registrasi surat ke dalam web serta hambatan-hambatan dalam implementasinya; dan (3) Arsip dalam web memiliki ruang yang tidak terbatas, proses penemuan kembali arsip menjadi mudah, arsip dalam file sebagai cadangan dan proses pengontrolan oleh Kepala Madrasah dan Kepala TU menjadi mudah.