bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia
Authors: Wang Yaping , Wu Peng , Lin Rufeng , Rong Liucheng , Xue Yao , Fang Yongjun 
Published: September 2015

AbstractLong non-coding RNA (lncRNA) was referred to be participating in various malignant tumors. Location based analysis of the mechanism in lncRNA and genes have been highly focused. In this study, we reported that lncRNA named NALT which was located near NOTCH1 within 100 bp away. We confirmed that up-regulation of NALT associating with NOTCH1 in human samples. Increased expression of NALT dramatically promoted cell proliferation in cell lines via CCK8 assay and EDU stain. Further xenograft tumor also indicated the growth inducing affection of NALT while could be partial reversed by GSI. Besides, through sorting the side-population cells in T ALL cells treated with NALT shRNA could decrease percentage of SP cell which companied by the down-regulation of NOTCH1. Gal4-λN/BoxB reporter system revealed that the nuclear located NALT could function as a transcription activator which caused an activation of NOTCH signal pathway as confirmed by western blot. Taken together, we found a neighbor of NOTCH1, Lnc-RP11-611D20.2 (named NALT) which could regulate the NOTCH1 signal pathway through cis-regulation. This founding may trigger a comparable development of diagnosis or novel molecularly-directed therapies.
Does a land‐based compensatory strength‐training programme influences the rotator cuff balance of young competitive swimmers?
Authors: Batalha Nuno , Raimundo Armando , Tomas‐Carus Pablo , Paulo João , Simão Roberto , Silva António J. 
Published: September 2015

AbstractDuring the repeated execution of the swimming strokes, the shoulder adductor and internal rotator muscles have a tendency to become proportionally stronger when compared to their antagonist group. This can lead to muscle imbalances. The aim of this study was to examine the effects of a compensatory training programme on the strength and balance of shoulder rotator muscles in young swimmers. A randomized controlled trial design was used. Forty male swimmers took part in the study and were randomly divided into two groups: an experimental group (n = 20) and a training group (n = 20). A control group (n = 16) of young sedentary male students was also evaluated. The experimental group subjects participated in a 16‐week shoulder‐strength programme with Thera‐Band® elastic bands; the training group was restricted to aquatic training. Peak torque of shoulder internal rotator and external rotator (ER) was measured at baseline and after 16 weeks. Concentric action at 1.04 rad s−1 (3 reps) and 3.14 rad s−1 (20 reps) was measured using an isokinetic dynamometer. The strength‐training programme led to an improvement of the ER strength and shoulder rotator balance in the experimental group (data from both shoulders at 1.04 rad s−1). Moreover, concentric action at 3.14 rad s−1 presented significant differences only for the dominant shoulder. Findings suggest that the prescribed shoulder‐strengthening exercises could be a useful training option for young competitive swimmers. They can produce an increase in absolute strength values and greater muscle balance in shoulder rotators.
Extensive Recruitment of Plasma Blasts to the Cerebrospinal Fluid in Toscana Virus Encephalitis
Authors: Schirmer Lucas , Wölfel Silke , Georgi Enrico , Ploner Markus , Bauer Barbara , Hemmer Bernhard 
Published: September 2015

AbstractAn unexpectedly extensive recruitment of B cells and plasma blasts to the cerebrospinal fluid (CSF) in a patient with Toscana virus (TOSV) encephalitis is described. Acute infection by TOSV was demonstrated by serological methods and by detection of TOSV-specific nucleic acid in the CSF by real-time polymerase chain reaction and sequencing.
SN2‐Palmitate Reduces Fatty Acid Excretion in Chinese Formula‐fed Infants
Authors: Bar‐Yoseph Fabiana , Lifshitz Yael , Cohen Tzafra , Malard Patrice , Xu Chungdi 
Published: September 2015

ABSTRACTObjectives:Palmitic acid (PA) comprises 17% to 25% of human milk fatty acids, of which 70% to 75% are esterified to the SN2 position of the triglyceride (SN2‐palmitate). In vegetable oils, which are commonly used in infant formulas, palmitate is primarily esterified to other positions, resulting in reduced calcium and fat absorption and hard stools. The aim of this study was to elucidate the effects of SN2‐palmitate on nutrient excretion.Methods:In total, 171 Chinese infants were included (within 14 days of birth) in this multicenter study. Formula‐fed infants were randomly assigned to receive either SN2‐palmitate formula (INFAT, n = 57) or control formula (n = 57). The formulas (Biostime, China) differed only in their SN2 PA proportions. Stool was collected at 6 postnatal weeks.Results:The stool dry weight and fat content of the SN2‐palmitate group were lower compared with the control group (dry weight 4.25 g vs 7.28 g, P < 0.05; fat 0.8 g vs 1.2 g, P < 0.05). The lipid component was also significantly lower for the SN2‐palmitate group (0.79 g vs 1.19 g, P < 0.05). PA, representing ∼50% of the saponified fatty acids, was significantly lower in the SN2‐palmitate group compared with the control group (0.3 g vs 0.7 g, P < 0.01). Breast‐fed infants had a significantly lower stool dry weight, fat content, and saponified fat excretion compared with formula‐fed infants (P < 0.01).Conclusions:Similar to breast milk, the SN2‐palmitate infant formula primarily reduced calcium‐saponified fat excretion. The results of this study further emphasize the nutritional importance of SN2‐palmitate structured fat for infants.
Sampling networks of ecological interactions
Authors: Jordano Pedro 
Published: September 2015

SummarySampling ecological interactions presents similar challenges, problems, potential biases, and constraints as sampling individuals and species in biodiversity inventories. Interactions are just pairwise relationships among individuals of two different species, such as those among plants and their seed dispersers in frugivory interactions or those among plants and their pollinators. Sampling interactions is a fundamental step to build robustly estimated interaction networks, yet few analyses have attempted a formal approach to their sampling protocols.Robust estimates of the actual number of interactions (links) within diversified ecological networks require adequate sampling effort that needs to be explicitly gauged. Yet we still lack a sampling theory explicitly focusing on ecological interactions.While the complete inventory of interactions is likely impossible, a robust characterization of its main patterns and metrics is probably realistic. We must acknowledge that a sizable fraction of the maximum number of interactionsImaxamong, say,Aanimal species andPplant species (i.e.,Imax=AP) is impossible to record due to forbidden links, i.e., life-history restrictions. Thus, the number of observed interactionsIin robustly sampled networks is typicallyI ≪ Imax, resulting in extremely sparse interaction matrices with low connectance.Reasons for forbidden links are multiple but mainly stem from spatial and temporal uncoupling, size mismatches, and intrinsically low probabilities of interspecific encounter for most potential interactions of partner species. Ad-equately assessing the completeness of a network of ecological interactions thus needs knowledge of the natural history details embedded, so that for-bidden links can be “discounted” when addressing sampling effort.Here I provide a review and outline a conceptual framework for interaction sampling by building an explicit analogue to individuals and species sampling, thus extending diversity-monitoring approaches to the characterization of complex networks of ecological interactions. This is crucial to assess the fast-paced and devastating effects of defaunation-driven loss of key ecological interactions and the services they provide and the analogous losses related to interaction gains due to invasive species and biotic homogenization.
Genomic and phenotypic evidence for an incomplete domestication of South American grain amaranth (Amaranthus caudatus)
Authors: Stetter Markus G. , Müller Thomas , Schmid Karl J. 
Published: September 2015

AbstractThe process of domestication leads to major morphological and genetic changes, which in combination are known as domestication syndrome that differentiates crops from their wild ancestors. We characterized the genomic and phenotypic diversity of the South American grain amaranthAmaranthus caudatus, which has been cultivated for thousands of years and is one of the three native grain amaranths of South and Central America. Previously, several models of domestication were proposed including a domestication from the close relatives and putative ancestorsA. hybridusorA. quitensis. To investigate the evolutionary relationship ofA. caudatusand its two close relatives, we genotyped 119 amaranth accessions of the three species from the Andean region using genotyping-by-sequencing (GBS) and compared phenotypic variation in two domestication-related traits, seed size and seed color. The analysis of 9,485 SNPs revealed a strong genetic differentiation of cultivatedA. caudatusfrom the relativesA. hybridusandA. quitensis. The two relatives did not cluster according to the species assigment but formed mixed groups according to their geographic origin in Ecuador and Peru, respectively.A. caudatushad a higher genetic diversity than its close relatives and shared a high proportion of polymorphisms with their wild relatives consistent with the absence of a strong bottleneck or a high level of recent gene flow. Genome sizes and seed sizes were not significantly different betweenA. caudatusand its relatives, although a genetically distinct group ofA. caudatusfrom Bolivia had significantly larger seeds. We conclude that despite a long history of human cultivation and selection for white grain color,A. caudatusshows a weak genomic and phenotypic domestication syndrome and is an incompletely domesticated species because of weak selection or high levels of gene flow from its sympatric close undomesticated relatives that counteracted the fixation of key domestication traits.
Sampling the conformational space of the catalytic subunit of human γ-secretase
Authors: Bai Xiao-chen , Rajendra Eeson , Yang Guanghui , Shi Yigong , W Scheres Sjors H. 
Published: September 2015

AbstractHuman γ-secretase is an intra-membrane protease that cleaves many different substrates. Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid precursor protein lead to Alzheimer’s disease. Our previous cryo-EM structure of γ-secretase revealed considerable disorder in its catalytic subunit presenilin. Here, we introduce an image classification procedure that characterizes molecular plasticity at the secondary structure level, and apply this method to identify three distinct conformations in our previous sample. In one of these conformations, an additional transmembrane helix is visible that cannot be attributed to the known components of γ-secretase. In addition, we present a γ-secretase structure in complex with the dipeptidic inhibitorN-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycinet-butyl ester (DAPT). Our results reveal how conformational mobility in the second and sixth transmembrane helices of presenilin is greatly reduced upon binding of DAPT or the additional helix, and form the basis for a new model of how substrate enters the transmembrane domain.
Britain in bloom? A study into Chinese tourists’ experience
Authors: Lin Zhibin , He Guangren , Vlachos Ilias P. 
Published: September 2015

Purpose
– The purpose of this paper is to examine Chinese tourists’ experience of Britain based on a conceptual model of tourist satisfaction and destination loyalty, and to identify key issues that tourism organisations could address to provide an excellent experience for Chinese tourists.

Design/methodology/approach
– Data were collected in collaboration with a tour operator; and 275 valid responses were received. Partial Least Square Structural Equation Modelling was used for data analysis.

Findings
– The key destination attributes of Britain such as heritage sites, natural scenery and customer service provide an excellent experience for Chinese tourists. Other British destination attributes such as shopping facilities, food, accommodation, entertainment and night life are less impressive.

Research limitations/implications
– The sample was drawn from Chinese tourists visiting Britain on package tours, which limits the generalisation of results to other Chinese tourists and other European/Mediterranean destinations.

Practical implications
– There are two key challenges for British destination tourism managers: first, to maintain the current quality levels in the attributes that generate tourist satisfaction; and second, to concentrate on improving attributes with low performance ratings such as shopping, food and drink, accommodation, entertainment and night life. As the characteristics of Chinese tourists are culture-specific rather than destination-specific, tourism managers in other European destinations may find these recommendations useful too.

Originality/value
– This is one of the first studies to examine Chinese tourists’ experience of a European destination. The results reveal unique characteristics of Chinese tourist requirements, which provide useful implications for tourism organisations to adapt their service strategies to better cater to this growing group of travellers.
Are IPO underwriters paid for the services they provide?
Authors: Meoli Michele , Signori Andrea , Vismara Silvio 
Published: September 2015

Purpose
– The purpose of this paper is to relate the fees paid to IPO underwriters to the nature and quality of the services they provide.

Design/methodology/approach
– Controlling for the characteristics of the firm going public, the risk associated with the offering, and the reputation of the underwriter, the authors study on a sample of Italian IPOs whether a formal commitment by underwriters to provide ancillary services allows them to charge higher fees.

Findings
– The authors document that asking underwriters to stabilize stock price is costly to the issuer, while to support liquidity is not. The authors’ also show that underwriters stabilize IPOs that really need it, whereas the provision of liquidity support does not seem to be always aligned with the issuer’s interest.

Originality/value
– Investigating the Italian underwriting market is instructive for two main reasons. First, the institutional setting in IPOs is similar to most continental European countries, but significantly different from the US market. For instance, allocation policies in US IPOs are discretionary for both retail and institutional investors, while in Europe shares cannot be discretionarily allocated to retail investors. Second, the Italian market offers the opportunity to study the going-public decision outside the typical Anglo-Saxon financial systems. This is of interest because while both the UK and the USA have well-developed equity markets and a related industry of financial intermediation centered on providing equity, our analysis sheds light on financial intermediation of IPOs in a bank-centered system.
CEO inside debt, asset tangibility, and investment
Authors: Lu-Andrews Ran , Yu-Thompson Yin 
Published: September 2015

Purpose
– The authors intend to perform empirical analysis to test the theory proposed by Edmans and Liu (2011) that CEOs with more debt-like compensations care more about the liquidation value of the firm. The purpose of this paper is to examine the relations between CEO inside debt ratios and tangible assets (i.e. asset tangibility, liquidation value, and fixed asset investment).

Design/methodology/approach
– The authors use the Ordinary Least Square (OLS) contemporaneous and lead-lag regression analyses. They also use two-stage least-square (2SLS) regression analysis for robustness check.

Findings
– The findings are fourfold: first, CEO inside debt has a positive effect on asset tangibility of the firm; second, CEO inside debt has a positive effect on the liquidation value of the firm; third, CEO inside debt has a positive effect on the tangible asset investment (as measured by capital expenditures) of the firm; and fourth, these positive effects are found in both the contemporaneous year and the subsequent year and in both OLS and 2SLS frameworks. The research provides further evidence that CEOs with higher inside debt holdings exhibit safety-seeking behavior. The authors document direct proof for the theory proposed by Edmans and Liu (2011) that these CEOs, like any creditors, care a great deal of the asset tangibility and liquidation value of the firm.

Originality/value
– This study contributes to the existing literature by providing further empirical evidence to support that CEO inside debt holdings have impacts on firm investment decisions and capital allocations. Inside debt does help align the executive managers’ personal incentive with firms’ value, and mitigate the agency conflicts between managers and debt holders. This study provides significant empirical evidence to support the theory suggested by Edmans and Liu (2011) that CEOs with higher level of inside debt holdings do care a greater deal about the asset liquidation value of the firm, and these firms tend to invest more in tangible assets to preserve the liquidation value.
Corporate governance disclosure and share price accuracy
Authors: ElKelish Walaa Wahid , Hassan Mostafa Kamal 
Published: September 2015

Purpose– The purpose of this paper is to investigate the impact of corporate governance disclosure on share price accuracy of listed companies in the United Arab Emirates (UAE).Design/methodology/approach– Data on corporate governance disclosure were obtained from the financial statements of companies listed in the UAE stock market, and share price accuracy indices were crafted from each company’s weekly share price returns between 2008 and 2009, using generalized least squares regression analysis. Multiple regression analysis with fixed effects was then implemented to test the study hypotheses.Findings– Voluntary corporate governance disclosure has a significant positive impact on share price accuracy. There is also evidence that mandatory corporate governance disclosure plays an important positive role on share price accuracy in the UAE business environment.Research limitations/implications– This paper covers a two-year transitional period during implementation of a new corporate governance code in the emerging market of the UAE.Practical implications– This paper encourages corporate managers in the UAE, as well as in other countries with similar business conditions, to review their voluntary corporate governance disclosure policies in accordance with international good practice. The authors suggest that regulators and accounting standard setters should extend mandatory corporate governance disclosure rules for the benefit of stock market participants and the overall welfare of the economy.Originality/value– This paper extends the literature on the relationship between accounting disclosure and share price accuracy to include corporate governance disclosure in emerging market economies such as the UAE. It also shows the importance of both voluntary and mandatory corporate governance disclosure.
What is an author now? Discourse analysis applied to the idea of an author
Authors: Martínez-Ávila Daniel , Smiraglia Richard , Lee Hur-Li , Fox Melodie 
Published: September 2015

Purpose
– The purpose of this paper is to discuss and shed light on the following questions: What is an author? Is it a person who writes? Or, is it, in information, an iconic taxonomic designation (some might say a “classification”) for a group of writings that are recognized by the public in some particular way? What does it mean when a search engine, or catalog, asks a user to enter the name of an author? And how does that accord with the manner in which the data have been entered in association with the names of the entities identified with the concept of authorship?

Design/methodology/approach
– The authors use several cases as bases of phenomenological discourse analysis, combining as best the authors can components of eidetic bracketing (a Husserlian technique for isolating noetic reduction) with Foucauldian discourse analysis. The two approaches are not sympathetic or together cogent, so the authors present them instead as alternative explanations alongside empirical evidence. In this way the authors are able to isolate components of iconic “authorship” and then subsequently engage them in discourse.

Findings
– An “author” is an iconic name associated with a class of works. An “author” is a role in public discourse between a set of works and the culture that consumes them. An “author” is a role in cultural sublimation, or a power broker in deabstemiation. An “author” is last, if ever, a person responsible for the intellectual content of a published work. The library catalog’s attribution of “author” is at odds with the Foucauldian discursive comprehension of the role of an “author.”

Originality/value
– One of the main assets of this paper is the combination of Foucauldian discourse analysis with phenomenological analysis for the study of the “author.” The authors turned to Foucauldian discourse analysis to discover the loci of power in the interactions of the public with the named authorial entities. The authors also looked to phenomenological analysis to consider the lived experience of users who encounter the same named authorial entities. The study of the “author” in this combined way facilitated the revelation of new aspects of the role of authorship in search engines and library catalogs.
Augmenting Dublin Core digital library metadata with Dewey Decimal Classification
Authors: Khoo Michael John , Ahn Jae-wook , Binding Ceri , Jones Hilary Jane , Lin Xia , Massam Diana , Tudhope Douglas 
Published: September 2015

Purpose– The purpose of this paper is to describe a new approach to a well-known problem for digital libraries, how to search across multiple unrelated libraries with a single query.Design/methodology/approach– The approach involves creating new Dewey Decimal Classification terms and numbers from existing Dublin Core records. In total, 263,550 records were harvested from three digital libraries. Weighted key terms were extracted from the title, description and subject fields of each record. Ranked DDC classes were automatically generated from these key terms by considering DDC hierarchies via a series of filtering and aggregation stages. A mean reciprocal ranking evaluation compared a sample of 49 generated classes against DDC classes created by a trained librarian for the same records.Findings– The best results combined weighted key terms from the title, description and subject fields. Performance declines with increased specificity of DDC level. The results compare favorably with similar studies.Research limitations/implications– The metadata harvest required manual intervention and the evaluation was resource intensive. Future research will look at evaluation methodologies that take account of issues of consistency and ecological validity.Practical implications– The method does not require training data and is easily scalable. The pipeline can be customized for individual use cases, for example, recall or precision enhancing.Social implications– The approach can provide centralized access to information from multiple domains currently provided by individual digital libraries.Originality/value– The approach addresses metadata normalization in the context of web resources. The automatic classification approach accounts for matches within hierarchies, aggregating lower level matches to broader parents and thus approximates the practices of a human cataloger.