bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Do Forecast Model Biases Affect Large-Scale Teleconnections That Control Southwest U.S. Precipitation? Part I: S2S Models
Authors: Dong Cameron , Peings Yannick , Magnusdottir Gudrun 
Published: July 2024

Abstract
We analyze biases in subseasonal forecast models and their effect on Southwest United States (SWUS) precipitation prediction (2–6-week time scale). Cluster analyses identify three primary wave trains associated with SWUS precipitation: a meridional El Niño–Southern Oscillation (ENSO)–type wave train, an arching Pacific–North American (PNA)–type wave train, and a circumglobal zonal wave train. Compared to reanalysis, the models overrepresent the arching pattern, underrepresent the zonal pattern, and produce mixed results for the meridional pattern. The arching pattern overrepresentation is linked to model mean flow biases in the midlatitude–subpolar North Pacific, which cause a westward retraction of the region of forbidden linear Rossby wave propagation. The zonal pattern underrepresentation is linked to westerly biases in the subtropical jet, which cause a westward retraction of the waveguide in the midlatitude eastern North Pacific and divert wave trains southward. These results are confirmed using linear, barotropic ray-tracing analysis. In addition to mean state biases, the models also contain errors in their representation of the Madden–Julian oscillation (MJO). Tropical convection anomalies associated with the MJO are too weak and incoherent at lead times greater than 2 weeks when compared to reanalysis. Additionally, there is a strong SWUS precipitation signal as far out as 5 weeks after a strong MJO in reanalysis, associated with its persistent eastward propagation, but this signal is absent in the models. Our results indicate that there is still significant room for improvement in subseasonal predictions if we can reduce model biases in the background flow and improve the representation of the MJO.
A Combined Scheme based on the Multiscale Stochastic Perturbed Parameterization Tendencies and Perturbed Boundary Layer Parameterization for a Global Ensemble Prediction System
Authors: Peng Fei , Li Xiaoli , Chen Jing 
Published: July 2024

Abstract
Stochastic representations of model uncertainties are of great importance for the performance of ensemble prediction systems (EPSs). The stochastically perturbed parameterization tendencies (SPPT) scheme with a single-scale random pattern has been used in the operational global EPS of China Meteorological Administration (CMA-GEPS) since 2018. To deal with deficiencies in this operational single-scale SPPT scheme, a combined scheme based on the multiscale SPPT (mSPPT) scheme and the stochastically perturbed parameterization for the planetary boundary layer (SPP-PBL) scheme is developed. In the combined scheme, the mSPPT component aims to expand model uncertainties characterized by SPPT at mesoscale, synoptic scale, and planetary scale. The SPP-PBL component with six vital parameters is used to capture uncertainties in PBL processes, which is underrepresented by SPPT for the tapering treatment within PBL. Comparisons between the operational SPPT scheme and the mSPPT scheme reveal that the mSPPT scheme can generate more improvements in both ensemble reliability and forecast skills mainly in tropics. Besides, additional benefits from SPP-PBL on top of mSPPT are shown to be primarily distributed in tropics at the lower layers below 850 hPa and surface. Furthermore, the combined scheme of mSPPT and SPP-PBL is suggested to yield better spread–error relationships and forecast skills than the operational SPPT scheme in terms of objective verification scores for standard upper-air variables and surface parameters. A case study for the extreme precipitation event on 20 July 2021 in Henan Province of China also demonstrates the better ability of the combined scheme in forecasting the precipitation intensity and location.
Significance Statement
A comprehensive and reasonable representation of model uncertainties helps to improve the performance of ensemble prediction systems (EPSs). Despite the popular usage in simulating model uncertainties, the stochastically perturbed parameterization tendencies (SPPT) scheme possesses several shortcomings. To overcome this, a combined scheme based on the multiscale SPPT (mSPPT) scheme and the stochastically perturbed parameterization for the planetary boundary layer (SPP-PBL) scheme is proposed. Based on the global EPS of China Meteorological Administration (CMA-GEPS), additional benefits from the independent usage of mSPPT and SPP-PBL are disclosed. And the combined scheme can inherit the merits of mSPPT and SPP-PBL and generate more improvements on ensemble performance than the original single-scale SPPT scheme. This research provides a guideline for future upgradation of CMA-GEPS.
Technology Intensification and  Farmers’ Welfare: A Case  Study from Karnataka,  a Semi-arid State of India
Authors: Kapoor Shreya , Pal Barun Deb , Singhal Aditi , Anantha K. H. 
Published: July 2024

Technology adoption has been advocated to be an important way to improve agricultural productivity and welfare of the farmers in the semi-arid regions across the globe. Government of Karnataka implemented Bhoosamrudhi programme in four districts of the state (Bidar, Chikballapur, Dharwad and Udupi) as a pilot project to increase the crop yield and income of smallholder farmers. This programme was launched on the theme of technology adoption, along with convergence among different departments of agriculture. Farmers have been classified into five categories based on their levels of technology intensification to assess the impact of different levels of technology intensification on their income level. The research is built on a primary survey conducted in pilot districts of the state in 2018 over a sample of 1,465 farmer households. The results are generated using econometric methods of propensity score matching (PSM) and inverse probability weighted with regression adjustment (IPWRA), which highlight that higher the intensification, higher the net returns to the farmers. The results state that non-adopters would benefit additional ₹3,200 per month if they adopt at least one level of technology intensification. Hence, this programme turned out to be a successful model for smallholder farmers in semi-arid region of India. Steps should be taken to maintain and expand the momentum of the adoption to ensure food and livelihood security in the economy. JEL Codes: Q16, Q54, Q55, C13
The clinical picture of Castleman disease: a systematic review and meta-analysis
Authors: Hoffmann Christian , Oksenhendler Eric , Littler Sarah , Grant Lisa , Kanhai Karan , Fajgenbaum David C. 
Published: July 2024

Abstract
Castleman disease (CD) encompasses a spectrum of rare disorders, including unicentric CD (UCD), idiopathic multicentric CD (iMCD), and human herpesvirus 8–associated MCD (HHV8+ MCD). We performed a systematic review of publications reporting ≥5 cases of CD between 1995 and 2021, following preferred reporting items for systematic reviews and meta-analyses guidelines, to describe and compare subtypes. We extracted data on clinical symptoms and laboratory parameters as stated in international consensus diagnostic criteria for iMCD and estimated the frequency of each criterion using meta-analyses. We analyzed 32 studies describing 559 UCD, 1023 iMCD, and 416 HHV8+ MCD cases. Although many symptoms and laboratory abnormalities occurred at similar rates in patients with iMCD and HHV8+ MCD, patients with HHV8+ MCD had significantly higher rates of constitutional symptoms (46.6% vs 98.6%; P = .038) and splenomegaly (48.2% vs 89.2%; P = .031). Renal dysfunction was significantly more common in patients with iMCD than in patients with HHV8+ MCD before adjustment (36.9% vs 17.4%; P = .04; adjusted P = .1). Patients with UCD had lower rates of symptoms and laboratory abnormalities, although these were present in 20% of patients and were particularly pronounced in pediatric UCD. There are many similarities in the symptomatology of iMCD and HHV8+ MCD; many patients experience constitutional symptoms and organ dysfunction. Differences between these subtypes likely reflect differences in pathophysiology and/or comorbidity burdens.
Neutralizing antibody responses assessment after vaccination in people living with HIV using a surrogate neutralization assay
Authors: Batchi-Bouyou Armel Landry , Djontu Jean Claude , Ingoba Line Lobaloba , Mougany Jiré Séphora , Mouzinga Freisnel Hermeland , Dollon Mbama Ntabi Jacques , Kouikani Franck Yannis , Christ Massamba Ndala Arcel , Diafouka-kietela Steve , Ampa Raoul , Ntoumi Francine 
Published: July 2024

Abstract
Objective
HIV has been reported to interfere with protective vaccination against multiple pathogens, usually through the decreased effectiveness of the antibody responses. We aimed to assess neutralizing antibody responses induced by COVID-19 vaccination in PLWH in Brazzaville, Republique of the Congo.

Method
The study was conducted at the Ambulatory Treatment Center of the National HIV Program, in charge of over 6000 PLWH, and the health center of FCRM in Brazzaville, Republic of the Congo. Participants were divided into two groups: PLWH with well-controlled HIV infection (CD4 counts no older than one week ≥ 800 / mm3, undetectable viral load of a period no older than one week and regularly taking Highly Active Antiretroviral Therapy for at least 6 months) and PLWOH. These groups were subdivided by vaccination status: fully vaccinated with adenovirus-based vaccines (Janssen/Ad26.COV2.S and Sputnik/Gam-COVID-Vac) or inactivated virus vaccine (Sinopharm/BBIP-CorV) and a control group of unvaccinated healthy individuals. All participants were RT-PCR negative at inclusion and/or with no documented history of SARS-CoV-2 infection. ELISA method was used for detecting IgG and neutralizing Antibodies against SARS-CoV-2 antigens using a commercial neutralizing assay.

Results
We collected oropharyngeal and blood samples from 1016 participants including 684 PLWH and 332 PLWOH. Both PLWH and PLWOH elicited high levels of antibody responses after complete vaccination with inactivated virus vaccine (Sinopharm/BBIP-CorV) and adenovirus-based vaccines (Janssen/Ad26.COV2.S and Sputnik/Gam-COVID-Vac). Overall, no difference was observed in neutralization capacity between PLWOH and PLWH with well-controlled HIV infection.

Conclusion
The results from this study underline the importance of implementing integrated health systems that provide PLWH the opportunity to benefit HIV prevention and care, at the same time while monitoring their vaccine-induced antibody kinetics for appropriate booster schedules.
Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis
Authors: Aynalem Zewdu Bishaw , Adal Abebaw Bires , Ayele Temesgien Fentahun , Bayeh Gashaw Melkie , Yeshiwas Almaw Genet , Dessie Tadesse Miretie , Tsega Tilahun Degu 
Published: July 2024

AbstractIntroductionThe incidence of colorectal cancer (CRC) has been increasing in Sub-Saharan countries, including Ethiopia. However, the real mortality rate for CRC patients in Ethiopia has not been established. Therefore, this systematic review and meta-analysis aimed to determine the overall mortality rate and identify predictors among CRC patients in Ethiopia.MethodsPubMed, EMBASE, Web of Science, Scopus, Science Direct, and Google Scholar were searched to identify relevant articles. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were followed. The quality of the included studies was assessed using the Newcastle-Ottawa Scale Critical Appraisal checklist. A random effect model was used to estimate the pooled mortality rate and adjusted hazard ratio (AHR). Publication bias was assessed using funnel plots and Egger’s regression test, while heterogeneity was evaluated through the Cochran Q test and I2statistics.ResultsAfter reviewing 74 articles, only 7 studies met the criteria and were included in the analysis. The analysis revealed that the overall mortality rate among CRC patients in Ethiopia was 40.5% (95% confidence interval [CI]: 32.05, 48.87) while the survival rates at 1 year, 3 years, and 5 years were 82.3% (95% CI: 73.33, 91.31), 48.8% (95% CI: 43.35, 54.32), and 26.6% (95% CI: 21.26, 31.91) respectively. Subgroup analysis indicated that studies conducted after 2017 had higher mortality rates compared to those studied earlier (43.0% vs. 38.2%). Older age (AHR: 1.89, 95% CI: 1.27, 2.82); being married (AHR: 2.53, 95% CI: 1.79, 3.57); having comorbidities (AHR: 1.84, 95% CI: 1.45, 2.35); having high CEA levels (AHR: 2.06, CI: 1.35, 3.13); being in stage II (AHR: 4.13, 95% CI: 1.85, 9.22), III (AHR: 8.62, 95% CI: 3.88, 19.15), and IV (AHR: 8.06, CI: 2.89, 22.49) were the most important predictors.ConclusionIn Ethiopia, the mortality rate among individuals diagnosed with CRC is high, with two out of five patients dying from this disease. Age, marital status, CEA level, comorbidities, and cancer stage were identified as predictors of mortality in CRC patients. Therefore, early detection and screening should be prioritized, particularly for older patients, those who are married, have comorbidities, elevated CEA levels, and advanced cancer stages.
PICC tip dislodgement causing massive pleural effusion and atelectasis with acute respiratory failure: a case report
Authors: Zhu Yao , Qin Yao , Alvarez Juan Felipe , Yin Wanhong 
Published: July 2024

AbstractPeripheral intravenous central catheter (PICC) is a common tool for intravenous infusion for children who need central venous access. Although it is safe for physicians and nurses to place, complications like infection, occlusion, phlebitis, and bleeding can occur. We report a 5-month-old infant who suffered respiratory failure caused by catheter malposition resulting in massive fluid infusion into the thoracic cavity. Point-of-care ultrasound (POCUS) was utilized to identify a massive pleural effusion that prompted urgent drainage. Complications related to PICC in pediatric patients are not common but difficult to immediately identify sometimes. Therefore, careful attention should be paid by physicians to identify and reduce the risk of complications associated with PICC. Thus, visual tools are strongly advised to enhance the safety of invasive procedures.
Evidence of gene-nutrient interaction association with waist circumference, cross-sectional analysis
Authors: AlBaloul Anwar H. , Griffin Jennifer , Kopytek Alexandra , Elliott Paul , Frost Gary 
Published: July 2024

Abstract
Background and aims
Waist circumference (WC) is a significant indicator of body adiposity and is associated with increased mortality and morbidity of cardiovascular diseases. Although, single nutrient intake and candidate genes were previously associated with WC. Little is known about WC association with overall diet quality, genetic risk score and gene-nutrient interaction. This study aims to investigate the influence of overall diet quality and multiple WC-associated single nucleotide polymorphisms on WC. In addition to investigating gene-nutrient interaction association with WC.

Methods
This study explored cross-sectional data from two large sample-size studies, to provide reproducible results. As a representation of the UK population, the Airwave Health Monitoring Study (n = 6,502) and the UK-Biobank Cohort Study (n = 171,129) were explored for factors associated with WC. Diet quality was evaluated based on the Mellen Index for Dietary Approaches to Stop Hypertension (Mellen-DASH). The genetic risk score for WC (GRS-Waist) was calculated by screening the population genotype for WC-associated single nucleotide polymorphisms. Multivariate linear regression models were built to explore WC association with diet quality and genetic risk score. Gene-nutrient interaction was explored by introducing the interaction term (GRS-Waist X Mellen-DASH score) to multivariate linear regression analysis.

Results
The prevalence of high WC (Female > 80 cm, Male > 94 cm) was 46.5% and 51.7% in both populations. Diet quality and genetic risk score of WC were significantly associated with WC. There was no evidence of interaction between GRS-Waist, DASH diet scores and nutrient intake on WC.

Conclusion
This study’s findings provided reproducible results on waist circumference association with diet and genetics and tested the possibility of gene-nutrient interaction. These reproducible results are successful in building the foundation for using diet and genetics for early identification of those at risk of having high WC and WC-associated diseases. In addition, evidence on gene-diet interactions on WC is limited and lacks replication, therefore our findings may guide future research in investigating this interaction and investigating its application in precision nutrition.
Pasteurized form of a potential probiotic lactobacillus brevis IBRC-M10790 exerts anti-inflammatory effects on inflammatory bowel disease in vitro
Authors: Ebrahiminejad Ardeshir , Sepahi Abbas Akhavan , Yadegar Abbas , Meyfour Anna 
Published: July 2024

Abstract
Background
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal system. So far, no treatment has been identified that can completely cure IBD. Lactobacillus brevis is hypothesized to be beneficial in preventing inflammation. This study aimed to evaluate the potential probiotic effects of live and pasteurized L. brevis IBRC-M10790 on the in vitro cell co-culture model of IBD.

Methods
An in vitro intestinal model was established using a transwell co-culture system of Caco-2 intestinal epithelial cells and RAW264.7 macrophages. Inflammatory conditions were induced in RAW264.7 cells using lipopolysaccharide. The effects of live and pasteurized L. brevis IBRC-M10790 on inflammatory mediators and epithelial barrier markers were investigated.

Results
L. brevis IBRC-M10790 was able to significantly decrease the proinflammatory cytokines (IL-6, IL-1β, and TNF-α) and increase the anti-inflammatory cytokine (IL-10) in the in vitro co-culture system. In addition, L. brevis increased adherens and tight junction (TJ) markers (ZO-1, E-cadherin, and Occludin) in Caco-2 intestinal epithelial cells. Based on the results, pasteurized L. brevis showed a higher protective effect than live L. brevis.

Conclusions
Our findings suggest that live and pasteurized forms of L. brevis possess probiotic properties and can mitigate inflammatory conditions in IBD.
Resilience in the face of pandemic: exploring the influence of psychological flexibility on turnover intentions and burnout among critical care nurses in COVID-19 hospitals
Authors: El-Ashry Ayman Mohamed , Seweid Mohamed Mahmoud , Ghoneam Mohamed Adel , Abdelaliem Sally Mohammed Farghaly , Sabek Elsayed Mahmoud 
Published: July 2024

Abstract
Aim
Assess the levels of psychological flexibility, burnout, and turnover intention among critical care nurses and assess the impact of psychological flexibility on burnout, and turnover intention among critical care nurses.

Background
Burnout and turnover intentions among critical care nurses are rapidly increasing because of the challenges of COVID-19. There is a need for evidence-based interventions like psychological flexibility to be addressed in research to overcome those challenges.

Methods
A descriptive correlational research. A convenient sample of 200 critical care nurses working in COVID-19 hospitals from two governorates in Egypt. The sociodemographic and clinical data sheet, the work-related acceptance and action questionnaire, the Copenhagen burnout inventory, and the adopted version of the staff nurses’ intention to leave the nursing profession questionnaire were used.

Results
The majority of critical care nurses reported a moderate level of psychological flexibility (75.5%, Mean = 31.23), a moderate level of burnout (65.5%, Mean = 59.61), and low to moderate levels of intention to leave (73%, Mean = 5.95). Psychological flexibility has a statistically significant negative correlation with burnout (PC = -0.304, Sig = 0.000) and the intention to leave (PC = -0.258, Sig = 0.000). In addition, psychological flexibility has a predictable effect on decreasing burnout (R2 = 0.232) and intention to leave (R2 = 0.127) among critical care nurses.

Conclusion
critical care nurses in COVID-19 hospitals reported varied levels of burnout and an intention to leave that must be considered. The effect of psychological flexibility on burnout and intention to turnover highlighted the importance of improving it among critical care nurses by applying acceptance and commitment therapy as a management intervention.
Unveiling the factors influencing public knowledge and behaviours towards medication errors in Jordan: a cross-sectional study
Authors: Al Zoubi Sura , Gharaibeh Lobna , Amaireh Enas A. , AlSalamat Husam , Deameh Mohammad Ghassab , Almansi Amjad , Al Asoufi Yaqeen Majed , Alshahwan Hadeel , Al-Zoubi Zaha 
Published: July 2024

Abstract
Background
Medication errors are preventable incidents resulting from improper use of drugs that may cause harm to patients. They thus endanger patient safety and offer a challenge to the efficiency and efficacy of the healthcare system. Both healthcare professionals and patients may commit medication errors.

Methods and objectives
A cross-sectional, observational study was designed using a self-developed, self-administered online questionnaire. A sample was collected using convenience sampling followed by snowball sampling. Adult participants from the general population were recruited regardless of age, gender, area of residence, medical history, or educational background in order to explore their practice, experience, knowledge, and fear of medication error, and their understanding of this drug-related problem.

Results
Of the 764 participants who agreed to complete the questionnaire, 511 (66.9%) were females and 295 (38.6%) had a medical background. One-fifth of participants had experienced medication errors, with 37.7% of this segment reporting these medication errors. More than half of all medication errors (84, 57.5%) were minor and thus did not require any intervention. The average anxiety score for all attributes was 21.2 (The highest possible mean was 36, and the lowest possible was 0). The highest level of anxiety was seen regarding the risk of experiencing drug-drug interactions and the lowest levels were around drug costs and shortages. Being female, having no medical background, and having experience with medication errors were the main predictors of high anxiety scores. Most participants (between 67% and 92%) were able to recognise medication errors committed by doctors or pharmacists. However, only 21.2 to 27.5% of participants could recognise medication errors committed by patients. Having a medical background was the strongest predictor of knowledge in this study (P < 0.001).

Conclusion
The study revealed that the prevalence of self-reported medication errors was significantly high in Jordan, some of which resulted in serious outcomes such as lasting impairment, though most were minor. Raising awareness about medication errors and implementing preventive measures is thus critical, and further collaboration between healthcare providers and policymakers is essential to educate patients and establish effective safety protocols.