bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasal lavage VEGF and TNF‐α levels during a natural cold predict asthma exacerbations
Authors: Manthei D. M. , Schwantes E. A. , Mathur S. K. , Guadarrama A. G. , Kelly E. A. , Gern J. E. , Jarjour N. N. , Denlinger L. C. 
Published: August 2014

SummaryBackgroundAsthma exacerbations contribute to significant morbidity, mortality and healthcare utilization. Furthermore, viral infections are associated with asthma exacerbations by mechanisms that are not fully understood.ObjectiveThe aim of this analysis was to determine whether cytokine patterns in patients with colds could identify risks for subsequent asthma exacerbations.MethodsWe analysed cytokine levels in nasal lavage fluid (NLF) in 59 subjects (46 with asthma) with acute upper respiratory symptoms and after symptomatic resolution. Analyte choice was based on potential relevance to asthma exacerbations: antiviral (IFN‐α, IFN‐β, IFN‐γ, IFN‐λ1, IP‐10, TRAIL), cell recruiting (G‐CSF, IL‐1β, IL‐8, MCP‐1, MCP‐3, TNF‐α), polarizing (CXCL13, IL‐10, IL‐13, IL‐17, TSLP), and injury remodelling (fibronectin, IL‐33, MMP‐9, VEGF).ResultsThe overall cytokine response induced during viral infections was not different between asthmatic and non‐asthmatic individuals for a wide array of cytokines. However, mean levels of VEGF, TNF‐α and IL‐1β were 1.7‐, 5.1‐ and 4.7‐fold higher in samples from asthma subjects who exacerbated in the first 3 weeks of the cold compared with those who did not exacerbate (P = 0.006, 0.01, 0.048, respectively). Using receiver operating characteristic curve‐defined thresholds, high VEGF and TNF‐α levels predicted a shorter time‐to‐exacerbation after NLF sampling (25% exacerbation rate: 3 vs. 45 days, and 3 vs. 26 days; P = 0.03, 0.04, respectively).Conclusion and Clinical RelevanceAlthough they produce similar cytokine responses to viral infection as non‐asthmatics, asthmatics with higher levels of VEGF and TNF‐α in NLF obtained during acute cold phases predicted subsequent asthma exacerbations in this cohort of patients with mild‐to‐moderate disease. In the future, stratifying the risk of an asthma exacerbation by cytokine profile may aid the targeting of personalized treatment and intervention strategies.
Plasma miRNAs might be promising biomarkers of chronic obstructive pulmonary disease
Authors: Wang Maoyun , Huang Yuchuan , Liang Zong'an , Liu Dan , Lu Yanrong , Dai Ya , Feng Guanglin , Wang Changguo 
Published: August 2014

AbstractBackground and AimsWe previously showed that microRNAs (miRNAs) in plasma are potential biomarkers for cigarette smoking‐related lung fibrosis. Here, we want to find out promising miRNAs for early detection of chronic obstructive pulmonary disease (COPD).Methods and ResultsPlasma miRNAs profiling was performed in COPD patients, asthma patients, and matched healthy controls. There was a >2‐fold changes for all signature miRNAs between the COPD and control samples, with P values of < 0.05. Pathway analysis, taking into account enriched target mRNAs for these signature miRNAs, was also carried out. We found seven miRNAs were special expression in the COPD patients. Furthermore, changes of miR‐145‐5p, miR‐338‐3p and miR‐3620‐3p were consistent with the classification of new ABCD classification of COPD. Targeted gene promising proved those miRNAs acted in inflammatory mediators, regulation of proliferation and differentiation, oxidative stress and so on.ConclusionsThese results suggested that plasma miRNAs could be potential specific biomarker for early detection COPD.
Comparing transplant glomerulopathy in the absence of C4d deposition and donor‐specific antibodies to chronic antibody‐mediated rejection
Authors: Torres Irina B. , Salcedo Maite , Moreso Francesc , Sellarés Joana , Castellá Eva , Azancot M. Antonieta , Perelló Manel , Cantarell Carme , Serón Daniel 
Published: August 2014

AbstractIntroductionTransplant glomerulopathy (TG) is the characteristic lesion of chronic antibody‐mediated rejection (AMR). However, in some patients presents with no circulating HLA antibodies or C4d positivity.AimPatients with TG accomplishing criteria for chronic AMR were compared to patients with isolated TG.Patients and MethodsWe reviewed late (>6 months) graft biopsies performed between 2007 and 2010 (n = 75). Biopsies with C4d‐negative TG and no circulating donor‐specific antibody were called isolated TG (n = 12), and chronic AMR was defined according to Banff consensus (n = 17). HLA antibodies were evaluated by Luminex technology. Immunohistochemistry was performed to quantify graft infiltrating cells.ResultsPatients with isolated TG were older (52 ± 14 vs. 35 ± 14; p = 0.0048), received grafts from older donors (54 ± 16 vs. 41 ± 18; p = 0.0554), and displayed a lower inflammation in the glomerular (g‐score: 0.5 ± 0.5 vs. 1.0 ± 0.9; p = 0.0865; CD3 positive cells/glomeruli: 1.5 ± 2.9 vs. 4.4 ± 4.1; p = 0.0147), interstitial (i‐score: 1.2 ± 0.9 vs. 1.9 ± 1.0; p = 0.0685; CD45 positive cells/hpf: 18 ± 11 vs. 57 ± 68; p = 0.0132), and peritubular capillary (ptc‐score 0.2 ± 0.6 vs. 1.1 ± 0.9; p = 0.0089; CD45 positive cells/hpf: 3.7 ± 3.1 vs. 10.1 ± 7.4; p = 0.0290) compartments. Fifteen grafts were lost and graft survival was significantly lower in patients with chronic AMR (p = 0.0122).ConclusionIsolated TG is associated with less severe allograft inflammation and with a better outcome than chronic AMR.
International Classification of Functioning, Disability and Health Core Sets for children and youth with cerebral palsy: a consensus meeting
Authors: Schiariti Veronica , Selb Melissa , Cieza Alarcos , O'Donnell Maureen 
Published: August 2014

AimThe objective of this article is to report on the Core Sets developed for children and youth aged 0 to 18 years, with cerebral palsy (CP) based on the pediatric International Classification of Functioning, Disability and Health (ICF) by the World Health Organization (WHO).MethodA formal decision‐making and consensus process integrating evidence gathered from preparatory studies was followed. Preparatory studies included: a systematic literature review; an international expert survey; a qualitative study of children and youth with CP and their caregivers; and a clinical study. Relevant ICF categories were identified in a formal consensus process by international experts from different backgrounds. Twenty‐six international experts chosen by WHO region with expertise in CP attended the consensus meeting.ResultsOverall, five ICF Core Sets were developed: a Comprehensive Core Set (135 ICF categories); a Common Brief (25 ICF categories); and three age‐specific Core Sets: under 6 years (31 ICF categories), from 6 to <14 years (35 ICF categories) and from 14 to 18 years (37 ICF categories).InterpretationThese ICF Core Sets for children and youth with CP are the first ICF‐based tools developed for this population. The ICF Core Sets for children and youth with CP can be applied in clinical practice, research, teaching and administration. The application of the ICF Core Sets to this population will standardize the functional assessments of CP worldwide.
Toothbrushing after an erosive attack: will waiting avoid tooth wear?
Authors: Lussi Adrian , Lussi Jonas , Carvalho Thiago S. , Cvikl Barbara 
Published: August 2014

The purpose of this study was to determine if storage for up to 4 h in human saliva results in a decrease of erosive tooth wear (ETW) and in an increase of surface microhardness (SMH) of enamel samples after an erosive attack with subsequent abrasion. Furthermore, we determined the impact of individual salivary parameters on ETW and SMH. Enamel samples were distributed into five groups: group 1 had neither erosion nor saliva treatment; groups 2–5 were treated with erosion, then group 2 was placed in a humid chamber and groups 3–5 were incubated in saliva for 30 min, 2 h, and 4 h, respectively. After erosion and saliva treatments, all groups were treated with abrasion. Surface microhardness and ETW were measured before and after erosion, incubation in saliva, and abrasion. Surface microhardness and ETW showed significant changes throughout the experiment: SMH decreased and ETW increased in groups 2–5, regardless of the length of incubation in saliva. The results of groups 3–5 (exposed to saliva) were not significantly different from those of group 2 (not exposed to saliva). Exposure of eroded enamel to saliva for up to 4 h was not able to increase SMH or reduce ETW. However, additional experiments with artificial saliva without proteins showed protection from erosive tooth wear. The recommendation to postpone toothbrushing of enamel after an erosive attack should be reconsidered.
The interictal language profile in adult epilepsy
Authors: Bartha‐Doering Lisa , Trinka Eugen 
Published: August 2014

SummaryObjectiveThe purpose of this study was to systematically review the literature on the interictal language profile in adult patients with epilepsy.MethodsAn extensive literature search was performed using MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, PASCAL, and PSYNDEXplus databases. Key aspects of inclusion criteria were adult patients with epilepsy, patient number >10, and in‐depth qualitative investigations of a specific language modality or administration of tests of at least two different language modalities, including comprehension, naming, repetition, reading, writing, and spontaneous speech.ResultsOur search strategy yielded 933 articles on epilepsy and language. Of these, 31 met final eligibility criteria. Most included articles focused on temporal lobe epilepsy; only three studies were interested in the language profile of patients with idiopathic generalized epilepsies, and one study on frontal lobe epilepsy met inclusion criteria. Study results showed a pronounced heterogeneity of language abilities in patients with epilepsy, varying from intact language profiles to impairment in several language functions. However, at least 17% of patients displayed deficits in more than one language function, with naming, reading comprehension, spontaneous speech, and discourse production being most often affected.SignificanceThis review underscores the need to evaluate different language functions—including spontaneous speech, discourse abilities, naming, auditory and reading comprehension, reading, writing, and repetition—individually in order to obtain a reliable profile of language functioning in patients with epilepsy. Moreover, our findings show that in contrast to the huge scientific interest of memory functions in epilepsy, the examination of language functions so far played a minor role in epilepsy research, emphasizing the need for future research activities in this field.
Rethinking equine gastric ulcer syndrome: Part 1 – Terminology, clinical signs and diagnosis
Authors: Sykes B. W. , Jokisalo J. M. 
Published: August 2014

SummaryEquine gastric ulcer syndrome (EGUS) is a common condition in the horse. A series of recent articles highlighting differences in healing of squamous and glandular ulceration have reinvigorated interest in the condition. The purpose of this series of articles is to review the current thinking on EGUS with particular emphasis on the differences between diseases of the squamous and glandular mucosae. This article, the first will review the terminology, clinical signs and diagnosis of EGUS in the horse.
Genotypic trait variation modifies effects of climate warming and nitrogen deposition on litter mass loss and microbial respiration
Authors: Hines Jes , Reyes Marta , Mozder Thomas J. , Gessner Mark O. 
Published: August 2014

AbstractIntraspecific variation in genotypically determined traits can influence ecosystem processes. Therefore, the impact of climate change on ecosystems may depend, in part, on the distribution of plant genotypes. Here we experimentally assess effects of climate warming and excess nitrogen supply on litter decomposition using 12 genotypes of a cosmopolitan foundation species collected across a 2100 km latitudinal gradient and grown in a common garden. Genotypically determined litter‐chemistry traits varied substantially within and among geographic regions, which strongly affected decomposition and the magnitude of warming effects, as warming accelerated litter mass loss of high‐nutrient, but not low‐nutrient, genotypes. Although increased nitrogen supply alone had no effect on decomposition, it strongly accelerated litter mass loss of all genotypes when combined with warming. Rates of microbial respiration associated with the leaf litter showed nearly identical responses as litter mass loss. These results highlight the importance of interactive effects of environmental factors and suggest that loss or gain of genetic variation associated with key phenotypic traits can buffer, or exacerbate, the impact of global change on ecosystem process rates in the future.
Patients with AIDS‐defining cancers are not universally screened for HIV: a 10‐year retrospective analysis of HIV‐testing practices in a Swiss university hospital
Authors: Mosimann V , Cavassini M , Hugli O , Mamin R , Achtari C , Peters S , Darling KEA 
Published: August 2014

ObjectivesKaposi's sarcoma (KS), invasive cervical carcinoma (ICC) and non‐Hodgkin lymphoma (NHL) have been listed as AIDS‐defining cancers (ADCs) by the Centers for Disease Control and Prevention since 1993. Despite this, HIV screening is not universally mentioned in ADC treatment guidelines. We examined screening practices at a tertiary centre serving a population where HIV seroprevalence is 0.4%.MethodsPatients with KS, ICC, NHL and Hodgkin lymphoma (HL), treated at Lausanne University Hospital between January 2002 and July 2012, were studied retrospectively. HIV testing was considered part of the oncology work‐up if performed between 90 days before and 90 days after the cancer diagnosis date.ResultsA total of 880 patients were examined: 10 with KS, 58 with ICC, 672 with NHL and 140 with HL. HIV testing rates were 100, 11, 60 and 59%, and HIV seroprevalence was 60, 1.7, 3.4 and 5%, respectively. Thirty‐seven patients (4.2%) were HIV‐positive, of whom eight (22%) were diagnosed at oncology work‐up. All newly diagnosed patients had CD4 counts < 200 cells/μL and six (75%) had presented to a physician 12–236 weeks previously with conditions warranting HIV testing.ConclusionsIn our institution, only patients with KS were universally screened. Screening rates for other cancers ranged from 11 to 60%. HIV seroprevalence was at least fourfold higher than the population average. As HIV‐positive status impacts on cancer patient medical management, HIV screening should be included in oncology guidelines. Further, we recommend that opt‐out screening should be adopted in all patients with ADCs and HL.
Biomechanical Comparison of a Locking Compression Plate Combined With an Intramedullary Pin or a Polyetheretherketone Rod in a Cadaveric Canine Tibia Gap Model
Authors: Beierer Lucas H. , Glyde Mark , Day Robert E. , Hosgood Giselle L. 
Published: August 2014

ObjectiveTo compare the biomechanical properties of a 10‐hole 3.5 mm locking compression plate (LCP) with 2 proximal and 2 distal bicortical locked screws reinforced with either a Steinmann pin of 30–40% the medullary diameter or a poly‐ether‐ether‐ketone (PEEK) rod of ∼75% the medullary diameter in a cadaveric tibia gap model.Study DesignEx vivostudy.Sample PopulationCadaveric canine tibias (n = 8 pair).MethodsEach construct had a 10‐hole 3.5 mm LCP with 2 screws per fracture fragment using a comminuted tibia gap model. The Steinmann pin constructs had a 2.4 mm intramedullary pin whereas the PEEK‐rod constructs had a 6 mm intramedullary PEEK rod placed. Biomechanical testing included non‐destructive bi‐planar 4 point bending, torsion testing, and destructive axial compression. Testing produced the responses of failure load (N) in axial compression, stiffness (N/mm or N/°) in axial compression, torsion, lateral‐medial, and caudal‐cranial 4 point bending. Screw position within the PEEK‐rods was determined after explantation.ResultsThe PEEK‐rod constructs were significantly stiffer in axial compression (P < .005), lateral‐medial 4 point bending (P < .001), and in torsional loading (P < .031) than the Steinman pin constructs. There was no significant difference between the constructs for stiffness in caudal‐cranial 4 point bending (P = .32). The PEEK‐rod constructs failed at a significantly higher load than the Steinmann pin constructs (P < .001). All constructs failed by yielding through plastic deformation. Each screw penetrated the PEEK rod in all constructs but the position of the screw varied.ConclusionPEEK‐rod constructs failed at significantly higher loads and were significantly stiffer in 4 point lateral‐medial bending, axial compression, and torsion when compared with Steinmann pin constructs.
¿Pero trabajan las mujeres? No declaración y subestimación del empleo femenino en Malasia
Authors: FRANCK Anja Karlsson , OLSSON Jerry 
Published: August 2014

ResumenA partir de un trabajo de campo en el estado malayo de Penang, los autores contribuyen a comprender la no declaración y la subestimación del trabajo informal femenino en las encuestas de población activa. Señalan los sesgos derivados de los métodos de recopilación de datos y, partiendo del concepto de agencia, demuestran que las propias mujeres actúan por motivos estratégicos: declarándose como amas de casa y considerando sus actividades remunerativas como prolongación de sus tareas domésticas evitan enfrentarse a la norma social de género preservando al mismo tiempo sus intereses en lo que respecta al trabajo fuera del hogar.
Igualdad de género, trabajo a tiempo parcial y segregación en Europa
Authors: SPARREBOOM Theo 
Published: August 2014

ResumenEste artículo examina la segregación por género y por duración de la jornada laboral, y cómo interactúan, restringiendo las opciones profesionales de los trabajadores afectados. La relación compensatoria (excluyente) entre aumento del empleo femenino y disminución de la segregación por género es más fuerte en el empleo a tiempo completo. La segregación por género parece menor en el empleo a tiempo parcial, pero lo que determina el efecto del empleo a tiempo parcial en el nivel de segregación en el empleo total es la diferencia de las tasas de empleo a tiempo parcial de hombres y mujeres.
Increasing imputation and prediction accuracy for Chinese Holsteins using joint Chinese–Nordic reference population
Authors: Ma P. , Lund M.S. , Ding X. , Zhang Q. , Su G. 
Published: August 2014

SummaryThis study investigated the effect of including Nordic Holsteins in the reference population on the imputation accuracy and prediction accuracy for Chinese Holsteins. The data used in this study include 85 Chinese Holstein bulls genotyped with both 54K chip and 777K (HD) chip, 2862 Chinese cows genotyped with 54K chip, 510 Nordic Holstein bulls genotyped with HD chip, and 4398 Nordic Holstein bulls genotyped with 54K chip and with deregressed proofs for five milk production traits. Based on these data, the accuracy of imputation from 54K to HD marker data and the accuracy of genomic predictions in Chinese Holstein were assessed. The allele correct rate increased around 2.7 and 1.7% in imputation from the 54K to the HD marker data for Chinese Holstein bulls and cows, respectively, when the Nordic HD‐genotyped bulls were included in the reference data for imputation. However, the prediction accuracy was improved slightly when using the marker data imputed based on the combined HD reference data, compared with using the marker data imputed based on the Chinese HD reference data only. On the other hand, when using the combined reference population including 4398 Nordic Holstein bulls, the accuracy of genomic predictions increased 6.5 percentage points together with a reduction of prediction bias. The HD markers did not outperform the 54K markers in genomic prediction based on the present data. The results indicate that for Chinese Holsteins, it is necessary to genotype more individuals with 54K chip to increase reference population rather than increasing marker density.
Latina Adolescent Sleep and Mood: An Ecological Momentary Assessment Pilot Study
Authors: Garcia Carolyn , Zhang Lei , Holt Katie , Hardeman Rachel , Peterson Barbara 
Published: August 2014

ProblemSleep and mood represent two important malleable opportunities for adolescent health. This study investigated the sleep–mood relationship in adolescent girls.MethodsShort‐term, longitudinal design. Latina adolescents (N = 19, mean age 15) completed ecological momentary assessments on sleep (perceived quality, self‐report quantity) and mood (negative affect, positive affect, and positivity ratio).FindingsAdolescents sent 1,598 texts on sleep and mood. Bidirectional sleep–mood relationships were in expected directions; negative affect and the positivity ratio affect predicted adolescents' sleep quality.ConclusionsInterventions should encourage sleep–mood relationship awareness, and further research should identify significant differences to inform tailored interventions with adolescents.
Aortic arch atheroma and the risk of stroke: a meta‐analysis
Authors: Cui Xiaoyang , Li Yi , Liu Junfeng , He Sha , Liu Ming 
Published: August 2014

AbstractBackgrounds and objectivesEpidemiological studies have suggested that aortic atheroma may play a role in cerebral embolization; however, no meta‐analysis was conducted to evaluate the relationship between aortic atheroma and risk of stroke. The aim of this study was to investigate the association between the presence of aortic atheroma and risk of stroke.MethodsWe performed a comprehensive search of observational studies reporting the relationship between the presence of aortic atheroma and stroke using the PubMed, EMbase, the China National Knowledge Infrastructure database (CNKI), Chinese Technical Periodicals (VIP), and WanFang Data databases. Two reviewers independently assessed the eligibility and extracted data from the included studies. We performed the meta‐analysis to estimate the strength of the association according to Meta‐analysis of Observational Studies in Epidemiology (MOOSE) guideline and assessed the study quality by the Newcastle‐Ottawa Scale (NOS).ResultsWe identified 12 eligible studies with 3918 participants. The scores of the NOS of the included studies ranged from 5 to 9. The pooled estimate of strength of the association between the presence of aortic atheroma and stroke was statistical significant (OR = 3.93, 95%CI 2.86 to 5.40). In subgroup analysis according to plaques’ morphology, complex aortic atheroma had significantly higher (OR = 5.90, 95%CI 4.14 to 8.41) risk of stroke than protruding atheroma (OR = 3.75, 95%CI 3.05 to 4.61).ConclusionsThis study indicated that aortic atheroma significantly increased the risk of stroke by about four times. Patients with complex aortic atheroma have a higher risk of stroke than protruding atheroma.