bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convergence analysis of Krylov subspace methods
Authors: Liesen Jörg , Tichý Petr 
Published: May 2014

AbstractOne of the most powerful tools for solving large and sparse systems of linear algebraic equations is a class of iterative methods called Krylov subspace methods. Their significant advantages like low memory requirements and good approximation properties make them very popular, and they are widely used in applications throughout science and engineering. The use of the Krylov subspaces in iterative methods for linear systems is even counted among the “Top 10” algorithmic ideas of the 20th century. Convergence analysis of these methods is not only of a great theoretical importance but it can also help to answer practically relevant questions about improving the performance of these methods. As we show, the question about the convergence behavior leads to complicated nonlinear problems. Despite intense research efforts, these problems are not well understood in some cases. The goal of this survey is to summarize known convergence results for three well‐known Krylov subspace methods (CG, MINRES and GMRES) and to formulate open questions in this area. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Nitsche's method for interface problems in computa‐tional mechanics
Authors: Hansbo Peter 
Published: May 2014

AbstractWe give a review of Nitsche's method applied to interface problems, involving real or artificial interfaces. Applications to unfitted meshes, Chimera meshes, cut meshes, fictitious domain methods, and model coupling are discussed. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Basics and some applications of the mortar element method
Authors: Bernardi Christine , Maday Yvon , Rapetti Francesca 
Published: May 2014

AbstractWe describe the main characteristics of the mortar element method, together with the usual arguments for its numerical analysis in an abstract framework. We illustrate this presentation by focussing on mortar spectral element and mortar finite element methods. We give three examples of recent applications, concerning the treatment of non homogeneous media, eddy currents in moving conductors, and finite element mesh adaptivity. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Combinatorial Aspects in Sparse Elimination Methods
Authors: Bollhöfer Matthias , Schenk Olaf 
Published: May 2014

AbstractIn this paper we will give an overview on combinatorial algorithms in sparse elimination methods. Beside well established techniques that have been developed in the last twenty years a modern viewpoint of LU decomposition is presented that illustrates how the evolution of techniques in the last decade improved the performance of sparse direct solvers. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The Jacobi–Davidson method
Authors: Hochstenbach M.E. , Notay Y. 
Published: May 2014

AbstractThe Jacobi–Davidson method is a popular technique to compute a few eigenpairs of large sparse matrices. Its introduction, about a decade ago, was motivated by the fact that standard eigensolvers often require an expensive factorization of the matrix to compute interior eigenvalues. Such a factorization may be infeasible for large matrices as arise in today's large‐scale simulations. In the Jacobi–Davidson method, one still needs to solve “inner” linear systems, but a factorization is avoided because the method is designed so as to favor the efficient use of modern iterative solution techniques, based on preconditioning and Krylov subspace acceleration. Here we review the Jacobi–Davidson method, with the emphasis on recent developments that are important in practical use. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Realigning Demand and Supply Side Incentives to Improve Primary Health Care Seeking in Rural China
Authors: Powell‐Jackson Timothy , Yip Winnie Chi‐Man , Han Wei 
Published: May 2014

AbstractChina's recent and ambitious health care reform involves a shift from the reliance on markets to the reaffirmation of the central role of the state in the financing and provision of services. In collaboration with the Government of the Ningxia province, we examined the impact of two key features of the reform on health care utilisation using panel household data. The first policy change was a redesign of the rural insurance benefit package, with an emphasis on reorientating incentives away from inpatient towards outpatient care. The second policy change involved a shift from a fee‐for‐service payment method to a capitation budget with pay‐for‐performance amongst primary care providers. We find that the insurance intervention, in isolation, led to a 47% increase in the use of outpatient care at village clinics and greater intensity of treatment (e.g. injections). By contrast, the two interventions in combination showed no effect on health care use over and above that generated by the redesign of the insurance benefit package. Copyright © 2014 John Wiley & Sons, Ltd.
Pharmacokinetic analysis of 14C‐ursodiol in newborn infants using accelerator mass spectrometry
Authors: Gordi Toufigh , Baillie Rebecca , Vuong Le T. , Abidi Saira , Dueker Stephen , Vasquez Herbert , Pegis Priscilla , Hopper Andrew O. , Power Gordon G. , Blood Arlin B. 
Published: May 2014

AbstractPharmacokinetic studies in the neonatal population are often limited by the small volume of blood that can be collected. The high sensitivity of 14C‐accelerator mass spectrometry (AMS) enables pharmacokinetic studies to be conducted with greatly reduced sample volumes. We demonstrated the utility of AMS in infants by studying the plasma pharmacokinetic behavior of nanogram doses of 14C‐ursodiol administered as a non‐perturbing microdose or as a microtracer with therapeutic doses of non‐labeled ursodiol in infants. Five non‐cholestatic infants were administered 3 consecutive oral microdoses of 14C‐ursodiol: 8 ng (1.0 nCi), 26 ng (3.3 nCi), and 80 ng (10 nCi) 48 hours apart. Three additional infants with cholestasis were administered a single 80 ng (10.0 nCi) oral dose of 14C‐ursodiol together with a therapeutic dose of 40 mg/kg of non‐labeled ursodiol. A pharmacokinetic model describing ursodiol concentrations was developed using nonlinear mixed‐effects modeling. The pharmacokinetics of ursodiol in this pilot study were best described by a two‐compartment model with first‐order elimination. This study demonstrates the feasibility and utility of microdose and microtrace methodology in pediatric research.
Does short‐term placebo response predict the long‐term observation? Meta‐analysis on forced expiratory volume in 1 second from asthma trials
Authors: Yang Shuying , Gomeni Roberto , Beerahee Misba 
Published: May 2014

AbstractThe objectives of this work were: (1) to characterize the placebo FEV1 response in asthma; (2) to identify the potential factors with strong influence on FEV1; (3) to determine the predictability of the early (week 2) placebo FEV1 response to the longer term (week 12) FEV1 response. Placebo FEV1 data of about 800 subjects from 11 randomized 12‐week clinical trials in mild‐to‐moderate asthmatics were collected. Stepwise logistic regression methods using SAS were used to model the week 12 trough FEV1 change from baseline greater than a clinically relevant value (150 mL) and to select the predictive covariates. The study effect was assessed using hierarchical logistic regression models implemented in WinBUGS. The results indicated that the early (week 2) placebo response was significantly predictive of the FEV1 response at week 12. Age, baseline predicted FEV1, and season showed statistical significance in the model. The final model showed satisfactory predictability with the area under the receiver operating characteristic curve (ROC) of 80%. The late (week 12) FEV1 response with placebo was positively related to the early (week 2) FEV1 change. The use of the predictive modeling approach proposed in this article presents a valuable method to increase the efficiency of clinical trial design in asthma population.
Influence of HepG2 cell shape on nanoparticle uptake
Authors: Prats‐Mateu Batirtze , Ertl Peter , Toca‐Herrera José Luis 
Published: May 2014

ABSTRACTCell mechanics provides insights in cell responses to external stress, which is an important parameter known to influence a variety of cell functions. Understanding the interdependence between mechanical stimulus, cell shape and function is essential in controlling cell culture microenvironment. In this paper, we report on the effect of cationic and anionic interfaces on cell shape and nanoparticle uptake activity of hepatocellular carcinoma cells HepG2. The shape of HepG2 cells changed from a round‐like shape to a spread‐like form exhibiting lamellar protrusions by incubating them on coated polystyrene well plates with polystyrene sulfonate and poly‐ethylene imine (PEI), respectively. This change in shape of HepG2 cells did not influence the uptake of 49‐nm particles (which entered the cells by diffusion). However, the internalization of 240‐nm diameter particles was larger on cells seeded on cationic PEI. Particle uptake was measured at 4°C and 37°C; the optimal incubation time was 6 h. Cell shape and particle uptake were monitored by fluorescence and confocal microscopy. Quantification of particle internalization was carried out with flow cytometry. Microsc. Res. Tech. 77:560–565, 2014. © 2014 Wiley Periodicals, Inc.
Pharmacokinetics of gadobenate dimeglumine in children 2 to 5 years of age undergoing MRI of the central nervous system
Authors: Pirovano Gianpaolo , Kirchin Miles A. , Lorusso Vito , Patel Rutu , Shen Ningyan 
Published: May 2014

PurposeTo determine the pharmacokinetic profile of gadobenate dimeglumine in children aged between 2 and 5 years.Materials and MethodsFifteen children scheduled to undergo contrast‐enhanced MRI for suspected disease of the central nervous system received a single intravenous injection of 0.1 mmol/kg gadobenate dimeglumine. Children were stratified into three age groups: 2 to <3 years, 3 to <4 years, and 4 to 5 (i.e., <6 years). Serial blood and urine samples collected at prespecified time‐points before and after contrast administration were analyzed for gadolinium concentrations. Pharmacokinetic parameters were calculated using noncompartmental and compartmental techniques.ResultsMean values of 65.7 μg/mL for highest blood gadolinium concentration, 0.2 L/h/kg for blood clearance, 0.32 L/kg for steady‐state volume of distribution, and 1.2 h for terminal elimination half‐life were determined across all age groups combined. On average, more than 80% of the dose was eliminated in the urine during the first 24 h after administration. All pharmacokinetic parameters were similar between age groups and no effects of gender were noted. No adverse events considered related to gadobenate dimeglumine administration were reported.ConclusionIn terms of pharmacokinetic profile no dosage adjustment from the approved adult gadobenate dimeglumine dose of 0.1 mmol/kg bodyweight is necessary in children aged between 2 and 5 years. J. Magn. Reson. Imaging 2015;41:1096–1103. © 2014 Wiley Periodicals, Inc.
Solvent‐Free Fabrication of polyHIPE Microspheres for Controlled Release of Growth Factors
Authors: Moglia Robert , Whitely Michael , Brooks Megan , Robinson Jennifer , Pishko Michael , Cosgriff‐Hernandez Elizabeth 
Published: May 2014

The growth factor bone morphogenetic protein 2 (BMP‐2) is utilized in surgical procedures to improve bone regeneration; however, current treatments deliver BMP‐2 at amounts greater than 100 000 fold of physiological levels, which increases treatment costs and risk of side effects. Drug‐eluting microcarriers developed to improve these therapies have faced significant commercialization challenges including particle size distributions, solvent removal, low encapsulation efficiency, and bioactivity loss. In this study, a solvent‐free method is presented for fabrication of uniform polyHIPE microspheres for controlled growth factor release. Emulsion templating principles and fluid dynamics were used to fabricate uniform particles with tunable particle size (200–800 μm) and pore size (10–30 μm). The ability to independently tune particle and pore size is expected to provide excellent control of release kinetics. Overall, this solvent‐free method for making porous microspheres displays strong promise for the controlled release of BMP‐2 and other growth factors.
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G673 could be a novel mutational hot spot for intragenic suppressors of pheS5 lesion in Escherichia coli
Authors: Ponmani Thangaraj , Munavar M. Hussain 
Published: May 2014

AbstractThe pheS5 Ts mutant of Escherichia coli defined by a G293 → A293 transition, which is responsible for thermosensitive Phenylalanyl‐tRNA synthetase has been well studied at both biochemical and molecular level but genetic analyses pertaining to suppressors of pheS5 were hard to come by. Here we have systematically analyzed a spectrum of Temperature‐insensitive derivatives isolated from pheS5 Ts mutant and identified two intragenic suppressors affecting the same base pair coordinate G673 (pheS19 defines G673 → T673; Gly225 → Cys225 and pheS28 defines G673 → C673; Gly225 → Arg225). In fact in the third derivative, the intragenic suppressor originally named pheS43 (G673 → C673transversion) is virtually same as pheS28. In the fourth case, the very pheS5 lesion itself has got changed from A293 → T293 (named pheS40). Cloning of pheS+, pheS5, pheS5‐pheS19, pheS5‐pheS28 alleles into pBR322 and introduction of these clones into pheS5 mutant revealed that excess of double mutant protein is not at all good for the survival of cells at 42°C. These results clearly indicate a pivotal role for Gly225 in the structural/functional integrity of alpha subunit of E. coli PheRS enzyme and it is proposed that G673 might define a hot spot for intragenic suppressors of pheS5.
Digital liaisons: Engaging with digital curation theory and practice
Authors:   SIG Digital Libraries
Published: May 2014

AbstractAs librarians and information professionals are increasingly tasked with curating and making accessible digital materials, new information professionals must enter the workforce armed with the appropriate skills. New professionals must know both the theoretical underpinnings of digital curation and how to put those theories into practice in real life applications. This proposed session would provide undergraduates, master's students, and early professionals with the opportunity to engage with the theories and applications of digital curation, and to present on meaningful projects and experiences they have had, whether as a student or a practitioner. Participation would include posters and lightning talks to highlight the unique and valuable research and experiences this community has had engaging with digital curation theories and practice.
Spanning boundaries and disciplines: Linked, open and cloud‐based community metadata
Authors: Mitchell Erik , Srikantiaiah Kanti , Rathbun‐Grubb Susan , Moulaison Heather Lea , Greenberg Jane 
Published: May 2014

AbstractMetadata is an important component of trans‐disciplinary research and is increasingly important in digital scholarship in which linked, open and cloud‐based communities operate. These communities regularly access and create linked, open and cloud‐based data and as such require metadata systems and structures that fit their unique communities. The vast and growing world of digital assets provide a tremendous resource for generating metadata through automated and crowd‐sourced means. Likewise, metadata are increasingly being used to help connect disciplines and foster cross‐collection discovery. The five panelists in this session represent a diverse and multi‐disciplinary view of metadata creation and use and the research represented in this panel includes explorations of metadata in science‐based, humanities, library and cultural heritage institutions. Likewise, the research presented employs a variety of methods including computational, survey, and content analysis techniques. Each panel member therefore represents a unique view in metadata research. Drs. Erik Mitchell, Jane Greenberg, Kanti Srikantaiah, Heather Lea Moulaison and Susan Rathbun‐Grubb will discuss their current research streams, speaking to the above issues via an exemplary project they have chosen to describe. Interactivity between the panelists and among the audience members will be encouraged after the panelists have presented their projects for discussion. This panel has the endorsement and the support of the Special Interest Group for Classification Research (SIG‐CR).
Preparing for the academic job market: An interactive panel for doctoral students
Authors: Miller Karen , Christopherson Laura 
Published: May 2014

AbstractThis proposal expands on the basic format of the successful interactive doctoral student panel sponsored by SIG/ED at the 2012 ASIS&T annual meeting. The 2013 panel features panelists prepared to address audience questions on such topics as the traditional academic job market, alternative career paths including post‐doctoral opportunities, the development of personal research agendas, and the challenges of online instruction.The function of this panel is to provide an interactive platform for faculty members at all stages of their careers to provide advice and input for doctoral students nearing the completion of their doctoral work. This panel will provide valuable insight on finishing the dissertation, weighing post‐doctoral opportunities, entering the job market, and beginning an academic career. The format will allow participants to ask questions anonymously that may otherwise be embarrassing to ask. The panel will be of greatest use to those doctoral students at the end of their doctoral program, but, as proven in 2012, will also be of interest to doctoral students beginning their doctoral work and new assistant professors.
Altmetrics: Present and future – panel
Authors:   Sponsored by: ASIS&T SIG/MET, Bar‐Ilan Judit , Sugimoto Cassidy , Gunn Willian , Haustein Stefanie , Konkiel Stacy , Larivière Vincent , Lin Jennifer 
Published: May 2014

AbstractScholars are increasingly incorporating social media tools like blogs, Twitter, and Mendeley into their professional communication. Altmetrics tracks usage of these and similar tools to measure scholarly influence on the social Web. Altmetrics researchers and practitioners have amassed a growing body of literature and working tools to gather and analyze altmetrics and there is growing interest in this emerging subfield of scientometrics. In this panel, sponsored by SIG/MET, we will present results demonstrating the utility of alternative metrics from a variety of stakeholders: researchers, librarians, publishers and those participating in academic social media sites. We will discuss and debate the value and validity of such metrics with strong degrees of participation from the audience encouraged. Metrics, for better or worse, have had a presence in the lives of scholars–we will discuss the challenges and opportunities of altmetrics for the future.
Beyond the playlist: Looking at user‐generated collocation of cultural products through social tagging
Authors: Desrochers Nadine , Quan‐Haase Anabel , Pennington Diane Rasmussen , Laplante Audrey , Martin Kim , Spiteri Louise 
Published: May 2014

AbstractSocial tagging has become a common practice across a variety of platforms on the Web. In this panel, we propose to start with one title, Casino Royale, a James Bond novel by Ian Fleming, and the other cultural products that emanated from it (e.g., two movies, one song, visuals and images, articles and blog posts) to explore social tagging practices and other user‐generated content in a variety of different platforms. Goodreads, Last.fm, WordPress, Flickr and various library discovery systems will be used to expose the connections users establish between and among cultural products as well as to compare what tagging yields in different platforms. The results will be situated within the context of broader studies being performed by the panelists and audience members will be asked to contribute material for real‐time searches.
Uncovering epistemological assumptions underlying research in information studies
Authors: Fuller Steve , Hjørland Birger , Ibekwe‐SanJuan Fidelia , Ma Lai , Mai Jens Erik , Tennis Joseph , Warner Julian 
Published: May 2014

AbstractThere have been several calls from LIS researchers for practical or applied research not to ignore the epistemological assumptions underlying the systems and artifacts they design lest they showcase only the dominant theory at a given time. Others have also deplored the “epistemological promiscuity” or “eclecticism” of the field, its incessant borrowing of theories and models from elsewhere (interdisciplinarity) and the fact that the field has largely neglected the contributions that philosophy and epistemology could have made in its research. This problem raises that of the boundaries of LIS and is all the more troublesome because boundaries between epistemological theories are fuzzy. Indeed, some epistemological theories share the same basic assumptions or are historically derived from one another (rationalism and positivism, for instance). Gathering a wide array of acknowledged theorists in philosophy of science and epistemology, this panel aims to examine how research work in the LIS field can clearly articulate the epistemological assumptions underlying that research and under what constraints this can be achieved. The topic is of prime importance to Information studies as a whole and to ASIST as the scientific flag bearer of information scientists worldwide.
Applications of neuroimaging in information science: Challenges and opportunities
Authors: Gwizdka Jacek , Mostafa Javed , Moshfeghi Yashar , Bergman Ofer , Pollick Frank E. 
Published: May 2014

AbstractThis panel will discuss opportunities and challenges involved in applying cognitive neuroscience and neuroimaging in information science. The panelists will discuss lessons learned from related disciplines and will consider how neuroimaging tools, such as fMRI, fNIRS, and EEG, could contribute to information science.
The Temporal dimension in the study of knowledge bases: Approaches to understanding knowledge creation and representation over time
Authors: Adler Melissa , Tennis Joseph T. , Milojević Stas̆a , van Hooland Seth , Rogers Corinne , West Jevin D. 
Published: May 2014

AbstractThe panel explores the theoretical, methodological, and design aspects of the temporal dimension in the study of knowledge creation and representation and offers insights in both the challenges and the promising future directions. The goal of the panel is to start a collaborative discussion around a number of important themes.Categories and Subject DescriptorsApplied computing • Document management and text processing • Information systems • Content analysis and feature selection • Information systems • Clustering and classificationGeneral TermsYour general terms must be any of the following 16 designated terms: Management, Measurement, Documentation, Design, Languages.
High‐stakes information: Deciding what constitutes quality in our products of communication
Authors: Budd John M. , Burns C. Sean , Moulaison Heather Lea 
Published: May 2014

AbstractAs more information is digitized or born online, issues with assessment and preservation, in the forms of determining, reviewing, and describing it, increase. This is particularly true for what we might term high‐stakes information, or information that if not carefully assessed or preserved can result in harmful consequences. With the premise that scholarly information is high‐stakes information, the panel will take a tripartite approach to the consideration of what constitutes information quality in three distinct contexts: quality as an element of the research process, quality as a component of the scholarly communication process, and quality as a factor in the storage and long‐term access of the product of research. The researchers on this panel will present reviews of the literature and their research findings. After the presentations, the panelists will raise a series of questions in order to foster discussion with the audience