bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic phenotypic shifts and M2 receptor downregulation in bladder smooth muscle cells induced by mirabegron
Authors: Muderrisoglu A. E. , Ciotkowska A. , Rutz B. , Hu S. , Qian S. , Tamalunas A. , Stief C. G. , Hennenberg M. 
Published: July 2024

IntroductionMirabegron is available for treatment of overactive bladder (OAB). However, mechanisms underlying symptom improvements and long-term effects on bladder smooth muscle cells are uncertain. Contractility and growth of bladder smooth muscle contribute to OAB, and depend on smooth muscle phenotypes, and on muscarinic receptor expression. Here, we examined prolonged exposure to mirabegron (20–48 h) on phenotype markers, muscarinic receptor expression, and phenotype-dependent functions in human bladder smooth muscle cells (hBSMC).MethodsExpression of markers for contractile (calponin, MYH11) and proliferative (MYH10, vimentin) phenotypes, proliferation (Ki-67), and of muscarinic receptors were assessed by RT-PCR. Proliferation, viability, actin organization and contractions in cultured hBSMC were examined by EdU, CCK-8, phalloidin staining and matrix contraction assays.ResultsCalponin-1 mRNA decreased with 100 nM and 150 nM mirabegron applied for 20 h (0.56–0.6 fold of controls). Decreases were resistant to the β3-AR antagonist L-748,337 (0.34–0.55 fold, 100–150 nM, 20 h). After 40 h, decreases occured in the presence of L-748,337, but not without L-748,337. MYH11 mRNA increased with 150 nM mirabegron (40 h, 1.9 fold). This was partly preserved with L-748,337, but not observed after 20 h mirabegron exposure. Vimentin mRNA reduced with 150 nM mirabegron after 20 h, but not after 40 h, with and without L-748,337 (0.71–0.63 fold). MYH10 mRNA expression remained unaffected by mirabegron. Exposure to 150 nM mirabegron increased Ki-67 mRNA after 20 h in the presence of, but not without L-748,337, and after 40 h without, but not with L-748,337. Proliferation rates and actin organization were stable with 50–150 nM mirabegron (24 h, 48 h). Viability increased significantly after mirabegron exposure for 20 h, and by trend after 40 h, which was fully sensitive to L-748,337. M2 mRNA was reduced by 20 h mirabegron, which was resistant to L-748,337. Carbachol (3 µM) enhanced time-dependent contractions of hBSMC, which was inhibited by mirabegron (150 nM) in late phases (24 h), but not in early phases of contractions.Conclusion: Mirabegron induces dynamic phenotype alterations and M2 downregulation in hBSMC, which is paralleled by time-shifted anticontractile effects. Phenotype transitions may be involved in improvements of storage symptoms in OAB by mirabegron.
Exploring the relationship between frequent cannabis use, belief updating under uncertainty and psychotic-like symptoms
Authors: Liang Xinyi , Avram Maria-Mihaela , Gibbs-Dean Toni , Chesney Edward , Oliver Dominic , Wang Simiao , Obreshkova Stiliyana , Spencer Tom , Englund Amir , Diederen Kelly 
Published: July 2024

BackgroundCannabis users present an important group for investigating putative mechanisms underlying psychosis, as cannabis-use is associated with an increased risk of psychosis. Recent work suggests that alterations in belief-updating under uncertainty underlie psychosis. We therefore compared belief updating under uncertainty between cannabis and non-cannabis users.Methods49 regular cannabis users and 52 controls completed the Space Game, via an online platform used for behavioral testing. In the task, participants were asked to predict the location of the stimulus based on previous information, under different uncertainty conditions. Mixed effects models were used to identify significant predictors of mean score, confidence, performance error and learning rate.ResultsBoth groups showed decreased confidence in high noise conditions, and increased belief updating in more volatile conditions, suggesting that they could infer the degree and sources of uncertainty. There were no significant effects of group on any of the performance indices. However, within the cannabis group, frequent users showed worse performance than less frequent users.ConclusionBelief updating under uncertainty is not affected by cannabis use status but could be impaired in those who use cannabis more frequently. This finding could show a similarity between frequent cannabis use and psychosis risk, as predictors for abnormal belief-updating.
Photovoice for leveraging traditional, complementary, and integrative medicine amongst black adults to improve sleep health and overall health
Authors: Moise Rhoda , Chery Maurice , Wyrick Mykayla , Zizi Ferdinand , Seixas Azizi , Jean-Louis Girardin 
Published: July 2024

IntroductionAverage adults are recommended to have 7–8 h of sleep. However insufficient sleep (IS defined as &lt;7 h/nightly) is associated with increased risk of chronic diseases such as cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Traditional, complementary, and integrative medicine (TCIM), a burgeoning area of research and practice, leverages both modern and traditional approaches to improve health. Despite TCIM’s recognition as a tool to improve sleep and related outcomes, there is a gap in literature in addressing its impact among black individuals, who experience a disproportionate burden of IS and chronic disease. This qualitative study aimed to increase understanding of TCIM practices to overcome IS and overall health in black communities.MethodsUsing photovoice methodology, a qualitative tool which applies community-engaged principles to produce culturally informed results through interviews and digital media, consented participants were recruited from Miami, Florida and (1) instructed to capture images over one week that communicated their TCIM to improve sleep and overall health on their mobile device; (2) interviewed using individual, semi-structured procedures to add “voice” to the “photos” they captured for ~20 min; and (3) invited to participate in follow-up focus groups for refined discussion and data triangulation for ~1.5 h. Both individual and focus group interviews were conducted over Zoom with recordings transcribed for formal content analysis using Nvivo software.ResultsThe sample included N = 25 diverse US black individuals (M = 37, SD = 13, range 21–57). Approximately a quarter of the sample were unemployed (N = 7) and majority were women (N = 21). Results highlighted five themes including: (1) natural wellness (sleep supplements, comfort beverages, aromatherapy, herbalism, outdoors); (2) self-care (self-maintenance, physical activity, spatial comfort); (3) leisure (pet support, play); (4) mental stimulation (mindfulness, reading); and (5) spiritual wellness (faith-based practices). Study results elucidate the heterogeneity of diverse US black individuals regarding sociocultural knowledge, beliefs, and behaviors.ConclusionAddressing IS in black communities requires a comprehensive strategy that integrates cultural sensitivity, family and community dynamics, education, mental health support, and informed policymaking. Future studies should consider how sleep health literacy, stress appraisal, and coping strategies may vary by race/ethnicity for tailored intervention.
Income inequality and healthcare utilization of the older adults-based on a study in three provinces and six cities in China
Authors: Chi Zhang , Lun Hai , Ma Jiaxin , Zhou Yaping 
Published: July 2024

PurposeThe objective of this study is to gain a more nuanced understanding of the specific impact of income inequality on the utilization of healthcare services for older adults. Additionally, the study aims to elucidate the moderating and mediating roles of public transfer income and psychological health in this context.MethodsA systematic examination of the impact of income inequality on healthcare utilization among older adults was conducted through field questionnaire surveys in six cities across three major geographical regions (West, Central, and East). The analysis employed baseline regression, as well as mediating and moderating effect tests.ResultsFirst, there is a negative relationship between income inequality and the use of therapeutic healthcare services (β1 = −0.484, P &lt; 0.01) and preventive healthcare services (β2 = −0.576, P &lt; 0.01) by older adults. This relationship is more pronounced in the low- and medium-income groups as well as in the western region. The mediating effect of psychological state is significant (β3 = −0.331, P &lt; 0.05, β4 = −0.331, P &lt; 0.05). Public transfer income plays a significant role in regulation. The moderating effect of public transfer income on therapeutic services was more significant in low-income groups (β5 = 0.821, P &lt; 0.01). The moderating effect of public transfer income on preventive services was more significant in middle-income groups (β6 = 0.833, P &lt; 0.01).ConclusionThe study clearly demonstrates a significant negative correlation between income inequality and the utilization of healthcare services by older adults. Furthermore, the study reveals that this relationship is particularly pronounced among older adults in low- and medium-income and Western regions. This detailed analysis of regional and income level heterogeneity is of particular value in this field of research. Secondly, this study attempts to integrate the two pivotal dimensions of public transfer income and psychological state for the first time, elucidating their moderating and mediating roles in this relationship. The findings indicate that public transfer income serves as a moderating factor, exerting a notable “reordering effect” on income inequality and resulting in a “deprivation effect.” Such factors may impede the utilization of medical services, potentially influencing the psychological state of older adults.
Higher blood manganese level associated with increased risk of adult latent tuberculosis infection in the US population
Authors: Qi Min , Zhang Huan , He Jian-Qing 
Published: July 2024

BackgroundThe associations between blood heavy metal levels and latent tuberculosis infection (LTBI) have not been fully elucidated. The aim of this study was to investigate the potential association between blood heavy metal levels and LTBI in adults using National Health and Nutrition Examination Survey data from 2011 to 2012.MethodsWe enrolled 1710 participants in this study, and compared the baseline characteristics of participants involved. Multivariate logistic regression analysis, restricted cubic splines (RCS) analysis, along with subgroup analysis and interaction tests were utilized to explore the association between blood manganese (Mn) level and LTBI risk.ResultsParticipants with LTBI had higher blood Mn level compared to non-LTBI individuals (p &lt; 0.05), while the levels of lead, cadmium, total mercury, selenium, copper, and zinc did not differ significantly between the two groups (p &gt; 0.05). In the fully adjusted model, a slight increase in LTBI risk was observed with each 1-unit increase in blood Mn level (OR = 1.00, 95% CI: 1.00–1.01, p = 0.02). Participants in the highest quartile of blood Mn level had a threefold increase in LTBI risk compared to those in the lowest quartile (OR = 4.01, 95% CI: 1.22–11.33, p = 0.02). RCS analysis did not show a non-linear relationship between blood Mn level and LTBI (non-linear p-value = 0.0826). Subgroup analyses and interaction tests indicated that age, alcohol consumption, and income-to-poverty ratio significantly influenced LTBI risk (interaction p-values&lt;0.05).ConclusionIndividuals with LTBI had higher blood Mn level compared to non-LTBI individuals, and higher blood Mn level associated with increased LTBI risk.
Avaliação e indicações das terapias de reposição hormonal nos períodos pré e pós menopausa: uma revisão integrativa
Authors: Assis Isadora Ferolla Fiuza de , Figueiredo Júlia Bernardes Nascimento , Souza Júlia Botelho de , Passos Michael Zarnowski 
Published: July 2024

Introdução: Algumas mulheres na menopausa se queixam de sintomas que afetam a qualidade de vida delas. Para minimizar o impacto do climatério, menopausa e pós-menopausa é prescrito terapia hormonal para mulheres que não tem proscrição a respeito desse tratamento. Objetivo: Descrever indicações e contra indicações da terapia hormonal e avaliar os benefícios e malefícios desse recurso terapêutico. Métodos: Foi realizada uma revisão bibliográfica nos bancos de dados Pubmed, BVS e Scielo para identificar artigos que descrevessem o impacto da terapia hormonal no climatério, menopausa e pós-menopausa, na qualidade de vida desse grupo de mulheres. Resultados: Foram selecionados 14 artigos que abordaram o tema deste trabalho e a maioria concluiu que deve ser uma escolha individualizada para cada paciente, de acordo com sua idade e comorbidades, mas que possui benefícios que impactam consideravelmente no aumento da qualidade de vida dessa população, do que malefícios para tais mulheres. Conclusões: Esta revisão demonstrou que a terapia hormonal pode ser uma estratégia interessante para beneficiar pacientes no climatério, menopausa ou pós menopausa,com sintomas como fogachos e falta de libido por meio da melhora da qualidade de vida e diminuição desses sintomas.
Ангиопоэтиноподобный белок 3 типа – новая мишень гиполипидемической терапии
Authors: Помогайбо Б. В. , Филиппов А. Е. 
Published: July 2024

Ангиопоэтиноподобный белок 3 типа регулирует активность липопротеинлипазы и эндотелиальной липазы, и его наследуемый дефицит сопровождается стимуляцией липолиза, комбинированной гиполипидемией и снижением сердечнососудистого риска. Фармакологическое воздействие на ангиопоэтиноподобный белок 3 реализуется посредством воздействия моноклональных антител, антисмыловой таргетной терапии и прямого редактирования генома и представляет собой перспективный путь гиполипидемической терапии, независимый от функционирования рецепторов липопротеидов низкой плотности и эффективно корректирующий смешанные гиперлипидемии.
Эндоваскулярное лечение пациентов с сочетанием церебральных аневризм и стенозов прецеребральных артерий
Authors: Бобинов В. В. , Рожченко Л. В. , Петров А. Е. , Самочерных Н. К. , Самочерных К. А. 
Published: July 2024

Введение. Сочетание стеноза сонных артерий и внутричерепных аневризм встречается с частотой до 6,5%. Определение оптимального подхода к лечению данной группы пациентов включает минимизацию рисков как ишемического инсульта, так и разрыва аневризмы. Цель исследования. Анализ результатов хирургического лечения пациентов с сочетанием церебральных аневризм и стенозов прецеребральных артерий. Материал и методы. Был проведен ретроспективный анализ результатов лечения пациентов с церебральными аневризмами, сочетавшимися со стенозом сонной артерии, которым проводилось оперативное лечение в нашем учреждении в период с 2019 по 2020 год. Был проведен сравнительный анализ по основным показателям: пол, субарахноидальное кровоизлияние и транзиторная ишемическая атака в анамнезе, односторонний или двусторонний стеноз сонных артерий, количество аневризм, ипсилатеральное или контрлатеральное расположение аневризмы, степень стенозирования артерии, стабильность атеросклеротической бляшки, интра- и послеоперационные осложнения. Результаты. В исследование вошло 16 пациентов. Ангиопластика со стентированием сонной артерии выполнялась первым этапом у 3 пациентов, окклюзия или эмболизация аневризмы у 9 пациентов, одномоментное лечение проведено 4 пациентам. Наиболее частой локализацией аневризмы был офтальмический сегмент внутренней сонной артерии. Множественное аневризматическое поражение сосудов головного мозга было выявлено у 8 пациентов. Первоначальная ангиопластика сонной артерии ни у одного пациента в исследовании в последующем не ассоциировалась с разрывом аневризмы. Заключение. Сочетанный стеноз сонных артерий и внутричерепных аневризм встречаются относительно нередко. Ангиопластика сонных артерий как первый этап лечения, по нашему мнению, не увеличивает риск разрыва аневризмы в краткосрочной перспективе. Одномоментная окклюзия аневризмы и ангиопластика со стентированием сонной артерии являются методом выбора при наличии технической возможности.
Особенности липидного профиля у больных множественной миеломой
Authors: Самойлова Е. В. , Миронова Т. П. , Давыдкин И. Л. , Сустретов А. С. , Степанова Т. Ю. , Наумова К. В. 
Published: July 2024

Аннотация. В настоящее время сердечно-сосудистые и онкологические заболевания имеют самую высокую заболеваемость и смертность в мире. Известно, что 34,8% онкологических больных погибают от неонкологических причин. В их структуре 33% занимают сердечно-сосудистые заболевания (ССЗ). Также известно, что ССЗ обусловлено 15-20% летальных исходов в группе пациентов с множественной миеломой. По этой причине, представляется интересным изучение факторов риска развития и/или прогрессирования ССЗ у пациентов с впервые выявленной множественной миеломой (ММ) до начала и в процессе противоопухолевой терапии, на примере изучения липидного профиля в данной популяции пациентов. Цель: оценить параметры липидного профиля у больных с ММ до начала лечения и в процессе противоопухолевой терапии по схеме VCD. Материалы и методы: В исследование вошли 43 пациента (20 мужчин и 23 женщины, медиана возраста — 60 лет) с впервые выявленной множественной миеломой IIA стадии по Durie-Salmon в сочетании с артериальной гипертензией 1 степени, которые составили группу А. Группа В включала в себя 46 пациентов с артериальной гипертензией 1 степени. Заключение. Для пациентов с ММ до начала противоопухолевой терапии характерна более низкая концентрация общего холестерина и липопротеидов высокой плотности относительно группы пациентов без ММ. Однако в процессе терапии по схеме VCD, включающей бортезомиб, циклофосфамид и дексаметазон, наблюдается увеличение всех параметров липидного профиля.
DIGITAL TRANSFORMATION OF SUPPLY CHAIN MANAGEMENT
Authors: Мелехова В.Д. 
Published: July 2024

В статье рассматривается и приводится классификация цифровых решений, технологий и инструментов, которые могут быть применены в различных процессах и функциях цепочки поставок и основных сферах движения материального потока в рамках цепочки поставок. Анализируются перспективы цифровой трансформации в управлении цепочками поставок, а также обосновывается целесообразность перехода к сетевому подходу в управлении цепочками поставок, позволяющему выстроить более гибкую, прозрачную и надежную цепочку поставок. Выявляются и структурируются возможные цифровые технологии, такие как машинное обучение, облачные технологии, интернет вещей, блокчейн, продвинутая аналитика, в каждой из областей цепочки поставок, и на этой основе разрабатывается и предлагается модель на основе балльнорейтингового метода оценки, позволяющая компании на начальном этапе выявить приоритетное цифровое решение для внедрения. Предложенная модель апробирована автором для одной из сфер управления цепочкой поставок складирования, для этого были выделены ключевые процессы и рассмотрены возможные цифровые альтернативы в каждом из выделенных процессов. В заключении автор подчеркнул преимущества и недостатки предложенной модели и перспективы дальнейших научных исследований по данной теме.
The article is dedicated to provide and classify digital solutions, technologies and tools that can be applied in various processes and functions of the supply chain management and the main areas of the material flow within the supply chain. Also, the possibilities of digital transformation in supply chain management are analyzed, and the feasibility of a transition to a network approach in supply chain management that makes it possible to obtain a more flexible, transparent and reliable supply chain is substantiated. Possible digital technologies such as machine learning, cloud technologies, Internet of Things, blockchain, advanced analytics are identified and structured. On this basis, a model is developed and proposed on the basis of a scorerating evaluation method, which allows the company to identify at an early stage a priority digital solution for implementation. The proposed model was tested by the author for one of the supply chain management areas warehousing. Key processes were identified and possible digital alternatives were considered in each of the selected processes. In conclusion, the author emphasized the advantages and disadvantages of the proposed model and the prospects for further research on this topic.
CURRENT PROBLEMS OF OLDER PERSONS’ EMPLOYMENT
Authors: Мосина Д.А. 
Published: July 2024

Статья посвящена выявлению актуальных проблем трудоустройства лиц в возрастной категории старше 50 лет. Актуальность темы обусловлена изменениями в пенсионной системе России, которые происходят в настоящее время и описаны в данной статье. Приводится статистика, характеризующая ситуацию на рынке труда в сегменте трудоустройства лиц старше 50 лет, проанализирована динамика уровня безработицы в возрастных категориях 5059 лет и 6072 года. Основная часть статьи посвящена систематизации и анализу проблем трудоустройства лиц старшего возраста. Автором выявлено пять основных проблем: высокие требования к квалификации работников и необходимость переквалификации и переобучения возрастных работников (1) сокращение численности, при котором работодатели, в первую очередь, стараются уволить людей старшего возраста (2) возрастные предпочтения работодателей, связанные с формированием молодежных коллективов (3) низкая адаптивная способность работников старшего возраста, проработавших продолжительное время на одном месте работы (4) проблема взаимодействия подчиненных старшего возраста с молодыми руководителями (5). В статье описываются мнения экспертов по данным вопросам. Статья также содержит пути решения каждой из выявленных проблем.
The article is devoted to the identification of urgent employment problems of persons in the age category older than 50 years. The topic relevance is due to changes in the Russian pension system that are taking place at present and are described in this article. Statistics are presented that characterize the situation on the labor market in the persons over 50 years employment segment, the unemployment dynamics in the age categories of 5059 years and 6072 years is analyzed. The main part of the article is devoted to the systematization and analysis of the older people employment problems. The author identified five main problems: high requirements for the workers qualifications and the need for agerelated workers retraining (1) a reduction in the number of staff and employers, first of all, try to fire older people (2) employers age preferences related to the youth teams formation (3) low adaptive ability of older workers who have worked for a long time at one workplace (4) the older subordinates interaction problem with young leaders (5). The article describes the experts opinions on these issues. The article also contains solutions to each of the identified problems.