bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacometrics: Opportunity for Reducing Disease Burden in the Developing World: The Case of Africa
Authors: Pillai G , Davies G , Denti P , Steimer J‐L , McIlleron H , Zvada S , Chigutsa E , Ngaimisi E , Mirza F , Tadmor B , Holford NHG 
Published: August 2013

Pharmacometricians are virtually nonexistent in Africa and the developing world. The unrelenting burden of infectious diseases, which are often treated using medicines with narrow effectiveness and safety dose ranges, and the growing prevalence and recognition of non‐communicable diseases represent significant threats for the patients, although affording an opportunity for advancing science. This article outlines the case for pharmacometricians to redirect their expertise to focus on the disease burden affecting the developing world.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e69; doi:10.1038/psp.2013.45; published online 28 August 2013
Daily rhythms in antennal protein and olfactory sensitivity in the malaria mosquito Anopheles gambiae
Authors: Rund Samuel S. C. , Bonar Nicolle A. , Champion Matthew M. , Ghazi John P. , Houk Cameron M. , Leming Matthew T. , Syed Zainulabeuddin , Duffield Giles E. 
Published: August 2013

AbstractWe recently characterized 24-hr daily rhythmic patterns of gene expression in Anopheles gambiae mosquitoes. These include numerous odorant binding proteins (OBPs), soluble odorant carrying proteins enriched in olfactory organs. Here we demonstrate that multiple rhythmically expressed genes including OBPs and takeout proteins, involved in regulating blood feeding behavior, have corresponding rhythmic protein levels as measured by quantitative proteomics. This includes AgamOBP1, previously shown as important to An. gambiae odorant sensing. Further, electrophysiological investigations demonstrate time-of-day specific differences in olfactory sensitivity of antennae to major host-derived odorants. The pre-dusk/dusk peaks in OBPs and takeout gene expression correspond with peak protein abundance at night and in turn coincide with the time of increased olfactory sensitivity to odorants requiring OBPs and times of increased blood-feeding behavior. This suggests an important role for OBPs in modulating temporal changes in odorant sensitivity, enabling the olfactory system to coordinate with the circadian niche of An. gambiae.
The down-regulation of GNAO1 and its promoting role in hepatocellular carcinoma
Authors: Pei Xiaoyu , Zhang Jun , Wu Lijun , Lü Bin , Zhang Xiaojiao , Yang Dongqin , Liu Jie 
Published: August 2013

GNAO1 (guanine nucleotide-binding protein, α-activating activity polypeptide O) is a member of the subunit family of Gα proteins, which are molecular switchers controlling signal transductions and whose deregulation can promote oncogenesis. HCC (hepatocellular carcinoma) is one of the malignant tumours around the world, which summons novel biomarkers or targets for effective diagnosis and treatments. The present study was aimed to investigate the expression of GNAO1 in HCC patient tissues and the possible mechanisms by which it took effects. The expression of GNAO1 was detected by IHC (immunohistochemistry) and real-time qPCR (quantitative PCR). Cell proliferation test and cell senescence test were then performed to explore the role of GNAO1 in the occurrence and development of HCC. It was revealed that the level of GNAO1 was comparably less in HCC tissues than in the adjacent tissues. Furthermore, down-regulation of GNAO1 increased cell proliferation, while suppressing the senescence of HCC cells. In conclusion, our findings revealed and confirmed the importance of GNAO1 in HCC, indicating that GNAO1 is a potential biomarker as well as a promising therapeutic target for HCC.
Dissociable effects of surprise and model update in parietal and anterior cingulate cortex
Authors: O’Reilly Jill X. , Schüffelgen Urs , Cuell Steven F. , Behrens Timothy E. J. , Mars Rogier B. , Rushworth Matthew F. S. 
Published: August 2013

Significance
This study investigates the brain mechanisms by which people disregard their previous beliefs about their environment and start forming new beliefs. Surprising events are often a signal that one’s previous beliefs are no longer valid. Using brain imaging, we identified separate brain systems involved in dealing with the immediate consequences of surprise (i.e., reprogramming actions) and in updating one’s beliefs about the environment to predict future events accurately. We present a mathematical and neuroanatomical model of how brains adjust to change in their environment that may inform our understanding of neurological disorders in which this adjustment process fails.
ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion
Authors: Song Roy S. , Massenburg Ben , Wenderski Wendy , Jayaraman Vino , Thompson Lauren , Neves Susana R. 
Published: August 2013

Significance
ERK activity contributes to AMPA-type glutamate receptor (AMPAR) membrane insertion, but until now, there was no clear understanding how this regulation could happen. We have identified the motif of ERK inhibiting PDE4 and controlling PKA output as a key step in the dopamine-induced membrane trafficking of GluA1. The significance of this regulatory motif is that it provides a point of integration for ERK activating signals to modulate neuronal excitability by tuning the trafficking of AMPAR.
On the detectability of extragalactic fast radio transients
Authors: Lorimer D. R. , Karastergiou A. , McLaughlin M. A. , Johnston S. 
Published: August 2013

Abstract
Recent discoveries of highly dispersed millisecond radio bursts by Thornton et al. in a survey with the Parkes radio telescope at 1.4 GHz point towards an emerging population of sources at cosmological distances whose origin is currently unclear. Here, we demonstrate that the scattering effects at lower radio frequencies are less than previously thought, and that the bursts could be detectable at redshifts out to about z = 0.5 in surveys below 1 GHz. Using a source model in which the bursts are standard candles with bolometric luminosities ∼8 × 1044 ergs s−1 uniformly distributed per unit comoving volume, we derive an expression for the observed peak flux density as a function of redshift and use this, together with the rate estimates found by Thornton et al. to find an empirical relationship between event rate and redshift probed by a given survey. The non-detection of any such events in Arecibo 1.4 GHz survey data by Deneva et al., and the Allen Telescope Array survey by Siemion et al. is consistent with our model. Ongoing surveys in the 1–2 GHz band should result in further discoveries. At lower frequencies, assuming a typical radio spectral index α = −1.4, the predicted peak flux densities are 10 s of Jy. As a result, surveys of such a population with current facilities would not necessarily be sensitivity limited and could be carried out with small arrays to maximize the sky coverage. We predict that sources may already be present in 350 MHz surveys with the Green Bank Telescope. Surveys at 150 MHz with 30 deg2 fields of view could detect one source per hour above 30 Jy.
Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling
Authors: Barabás Orsolya , Németh Veronika , Bodor Andrea , Perczel András , Rosta Edina , Kele Zoltán , Zagyva Imre , Szabadka Zoltán , Grolmusz Vince I. , Wilmanns Matthias , Vértessy Beáta G. 
Published: August 2013

Abstract
Enzymatic synthesis and hydrolysis of nucleoside phosphate compounds play a key role in various biological pathways, like signal transduction, DNA synthesis and metabolism. Although these processes have been studied extensively, numerous key issues regarding the chemical pathway and atomic movements remain open for many enzymatic reactions. Here, using the Mason–Pfizer monkey retrovirus dUTPase, we study the dUTPase-catalyzed hydrolysis of dUTP, an incorrect DNA building block, to elaborate the mechanistic details at high resolution. Combining mass spectrometry analysis of the dUTPase-catalyzed reaction carried out in and quantum mechanics/molecular mechanics (QM/MM) simulation, we show that the nucleophilic attack occurs at the α-phosphate site. Phosphorus-31 NMR spectroscopy (31P-NMR) analysis confirms the site of attack and shows the capability of dUTPase to cleave the dUTP analogue α,β-imido-dUTP, containing the imido linkage usually regarded to be non-hydrolyzable. We present numerous X-ray crystal structures of distinct dUTPase and nucleoside phosphate complexes, which report on the progress of the chemical reaction along the reaction coordinate. The presently used combination of diverse structural methods reveals details of the nucleophilic attack and identifies a novel enzyme–product complex structure.
The effects of non-Newtonian rheology in the dynamic coefficients of wide slider bearings with a secant-shaped film profile
Authors: Lin Jaw-Ren , Lu Rong-Fang , Chu Li-Ming , Hung Chi-Ren 
Published: August 2013

Purpose
– The purpose of this paper is to investigate the effects of non-Newtonian rheology on the dynamic characteristics of a secant-shaped couple-stress lubricated slider bearing.

Design/methodology/approach
– By applying the linear dynamic theory to the film force equation, a closed-form solution of the stiffness and damping coefficients is obtained for the secant-shaped bearing taking into account the non-Newtonian effects of Stokes couple stress fluids.

Findings
– Comparing with the secant-shaped Newtonian-lubricant bearing, the effects of non-Newtonian couple stresses provide an apparent improvement in the dynamic stiffness and damping characteristics, especially for the secant-shaped slider bearing operating at lower squeezing-film heights and with larger non-Newtonian couple stress parameters.

Originality/value
– Comparing with those of the inclined plane-shaped non-Newtonian slider bearings, better dynamic stiffness and damping performances are provided for the secant-shaped non-Newtonian slider bearing designed at larger values of the shoulder parameters. The advantages of secant-shaped slider-bearing types provide engineers useful information in bearing selection and engineering application.
Improvement of MediaWiki to support mandatory collaboration
Authors: Kasemvilas Sumonta , Olfman Lorne 
Published: August 2013

Purpose
– The purpose of this study was to design collaboration mechanisms for groups, particularly those who are performing mandatory collaborative writing of Wiki pages.

Design/methodology/approach
– This research study utilized six design science research methodology steps. Two case studies were conducted to understand how a MediaWiki with additional extensions potentially facilitates collaborative writing. Questionnaires were used to collect answers to questions about perceived usefulness and perceived ease of use.

Findings
– The findings from this research led to the innovative design of a set of MediaWiki mechanisms to improve collaborative writing in the classroom setting. The findings of the second round of the build-and-evaluate loop illustrate some potential impacts of MediaWiki when used in the classroom.

Research limitations/implications
– These mechanisms would increase the students' sense of awareness, clarify management, increase discussion, and clarify students' roles. The implications of this study can be useful for researchers and developers. They can make use of what the study articulates the benefits and the needs of MediaWiki extensions.

Practical implications
– The results of this study potentially offer new mechanisms that can be used to teach graduate students involved in collaborative writing.

Originality/value
– The creation of the newly developed extensions is the original and innovative component of this study. These extensions are designed to increase project control and accountability.
Aligning technology with learning theories
Authors: Alimisis Dimitris , Zoulias Emmanouil 
Published: August 2013

Purpose
– The aim of this research is the development of a problem-based curriculum for robotic surgical training and its evaluation.

Design/methodology/approach
– First, the aim and objectives of the curriculum are defined and the background learning theories that guide our work are introduced. The methodology for designing the simulator-based training is presented and finally the output of this work is reported, that is the SAFROS training paradigm, resulted as a balanced synthesis of behavioural and constructivist learning theories.

Findings
– The evaluation of basic skills tasks of the curriculum revealed a high acceptance among the trainees.

Research limitations/implications
– Within this paper, a first implementation and evaluation of the basic skills tasks is described. Further cooperation between pedagogues and software engineers is required in order to put in practice the whole curriculum. Then, further training experiments with surgeons are necessary to check the validity of the whole curriculum. The authors also need to establish proficiency criteria that can come from the achievements of expert surgeons using the simulator and the robot and use them as final goals to be achieved by trainees in future courses. In the field of subjective evaluation, a possible future extension might be a bigger number of questions. Moreover, the innovative method of text mining in its application to opinion mining decisions can be further applied.

Originality/value
– In this paper, an innovative approach for the development of a simulator-based curriculum for robotic surgical training is presented and first evaluation results based on ratings from trainees are also presented. The value of this paper is relevant to medical trainers and curriculum designers.
Speech and touch enhanced interface for visually impaired users
Authors: Oppenheim Matthew 
Published: August 2013

Purpose
– This paper presents a novel interface system to aid people with visual impairment to become proficient with operating unfamiliar devices. The system works by adding touch sensors that trigger audio tags to tactile controls. The touch sensors trigger the audio tags before the control is activated.

Design/methodology/approach
– The paper describes how several devices were enhanced with the new technology, tested and evaluated. Initial informational interviewing with visually impaired people was followed by user studies with blindfolded but visually able people. A final evaluation of the system was conducted by a visually impaired group.

Findings
– This paper shows that the technology is of benefit to a visually impaired user when using a complex unfamiliar device.

Originality/value
– This novel application of touch sensors coupled with audio tags has the potential to benefit visually impaired people. This technology can easily be incorporated into commercial devices. The idea can also be implemented using off the shelf development boards coupled with smart phones.
Design and analysis of a novel earpiece‐less eyeglass frame
Authors: Griffin Byron , Yang James 
Published: August 2013

PurposeThe purpose of this paper is to present design and analysis of a novel earpiece‐less eyeglass frame.Design/methodology/approachA virtual assembly process was used to test the part design and finally a prototype was built to check the design.FindingsEarpiece‐less eyeglasses are easier to adjust for higher comfort levels and do not incorporate leg hinges compared to traditional eye‐glasses. This novel design is unique and will be in mass production.Originality/valueThis paper presents a novel earpiece‐less eyeglasses frame design and will have significant impact to the market.
Pioneering consumer economist: Elizabeth Ellis Hoyt (1893‐1980)
Authors: Parsons Elizabeth 
Published: August 2013

PurposeThis paper aims to contribute to the project of recognising the contribution of female scholars to the development of marketing thought. The paper presents a biography of Elizabeth Ellis Hoyt, a home economist, who contributed to the shaping of contemporary ideas about consumption and the consumer.Design/methodology/approachSource material used includes the Elizabeth Ellis Hoyt Papers (1884‐2009) in the Iowa State University Archives. The collection contains a variety of materials, of which the most important for this paper were news clippings, personal diaries (1907‐1918), and published and unpublished manuscripts (1953, 1964, n.d.). Also important for this study were two sources published by Alison Comish Thorne, Elizabeth Hoyt's PhD student. These include Thorne's autobiography Leave the Dishes in the Sink and her entry on Elizabeth Hoyt in the Biographical Dictionary of Women Economists.FindingsThe paper documents Elizabeth Hoyt's development of marketing thought, focusing on her early work on the cost of living index and subsequent contributions to an expanded theory of consumption and consumer learning.Originality/valueElizabeth Hoyt is one of a group of female home economists who pioneered consumption economics in America in the 1920s and 1930s yet who have been neglected in published accounts. Notwithstanding a short biographical note in the Biographical Dictionary of Women Economists, Hoyt's life and work are not yet documented.
Remembering female contributors to marketing theory, thought and practice
Authors: Tadajewski Mark , Maclaran Pauline 
Published: August 2013

PurposeThis editorial aims to review the contents of the special issue, situating it within appropriate historical context.Design/methodology/approachA close reading of the contents of the special issue is provided.FindingsThis special issue reveals the important contributions of a number of previously forgotten female pioneers in marketing, advertising and consumer research.Originality/valueThis introduction adds further historical detail about the structures and biases that have limited the opportunities available to female contributors to marketing theory, thought and practice.
Knowledge, skills and personality of the effective business consultant
Authors: Banai Moshe , Tulimieri Philp 
Published: August 2013

PurposeThe purpose of this paper to describe the effective business consultant's most desirable characteristics.Design/methodology/approachDevelopment of propositions based on a review of the literature, anecdotal reports and the experience of the authors.FindingsThe effective business consultant should possess functional knowledge as well as knowledge of an industry, communication and analytical skills, creativity, strategic and tactical leadership abilities, and a set of personality traits that includes emotional stability, intellect, integrity and openness and agreeableness.Practical implicationsHR departments and training units in consulting firms may use the profile of the effective consultant as a tool in their selection and training procedures, as well as in matching consultants with clients. Consulting services clients may use the profile of the effective consultant to identify effective consulting service providers. Consultants may use the recommendations as a source for individual growth. Universities and business schools may use the study to improve training of future consultants.Originality/valueThe paper sets a research agenda for the study of the effective business consultant's characteristics.
From white paper writing to white water rafting
Authors: Marques Joan , Holt Svetlana , Green Virginia 
Published: August 2013

PurposeThe purpose of the paper is to share practices with other scholars who are on the outlook for different, more rewarding ways of facilitating formal management education, and to invite feedback and additional suggestions from colleagues in formal and informal educational settings about additional approaches that make a positive difference.Design/methodology/approachThe paper is structured in a sequential format, presenting the three contributors’ practices in separate sections, yet unifying them through a coherent structure of a brief course description, a description of the creative infusion, and some sample implementations.FindingsManagement courses that focus on creativity, involvement, interaction, and a trans‐disciplinary approach, ensure greater cohesion between left‐ and right‐brain thinking.Practical implicationsManagement in an increasingly diversifying yet intertwining work environment brings along challenges that have not been encountered before. Some teaching scholars in higher education consider this challenge problematic, but others perceive it as a wonderful opportunity toward more effective and rewarding approaches to learning and communicating.Originality/valueThis paper presents a valuable piece of evidence, albeit on a minute scale, that scholars who engage in practice‐based management education and include elements from the real world in their courses, experience enhanced gratification within themselves and from their students.
Measuring the international usage of US institutional repositories
Authors: Fralinger Lauren , Bull Jonathan 
Published: August 2013

PurposeIn an educational world with increasing internationalization, digitization, assessment and financial justification, US institutions, especially academic libraries, must justify each new project. Institutional Repositories (IRs) are no exception. The authors attempt to identify factors that might affect the international usage of US IRs as part of assessment efforts to determine an IR's return‐on‐investment.Design/methodology/approachA survey was disseminated to IR administrators asking for demographic information, international usage counts for website hits and downloads, and any internationalization efforts connected to the IR in order to determine any influencing factors on an IR's international usage.FindingsWhile many IRs reported various rates of international usage, the largest group of respondents did not report an international usage rate for both page hits and downloads, despite overwhelmingly expressing an importance of international traffic to their IR and parent institution.Research limitations/implicationsIt is not clear if this non‐reporting of international usage could be due to ignorance, apathy, or lack of technological support on the part of the IR administrators.Practical implicationsDetermining international usage as a part of an IR assessment might be problematic or even impossible for many US IRs.Originality/valueThis study suggests that many IR administrators either do not know, do not care, and/or cannot record international usage data for their respective IRs, which could hinder determining an international return‐on‐investment for the IR.