bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biography and Homoeopathy in Bengal: Colonial lives of a European heterodoxy
Authors: DAS SHINJINI 
Published: April 2015

AbstractDespite being recognized as a significant literary mode in understanding the advent of the modern self, biographies as agenrehave received relatively little attention from South Asian historians. Likewise, histories of science and healing in British India have largely ignored the colonial trajectories of those sectarian, dissenting, supposedly pseudo-sciences and medical heterodoxies that have flourished in Europe since the late eighteenth century. This article addresses these gaps in the historiography to identify biographies as a principal mode through which an incipient, ‘heterodox’ Western science like homoeopathy could consolidate and sustain itself in Bengal. In recovering the cultural history of a category that the state archives render largely invisible, this article argues that biographies are more than a mere repository of individual lives, and in fact are a veritable site of power. In bringing histories of print and publishing, histories of medicine, and histories of life writing practices together, it pursues two broad themes: first, it analyses the sociocultural strategies and networks by which scientific doctrines and concepts are translated across cultural borders. It explores the relation between medical commerce, print capital, and therapeutic knowledge to illustrate that acculturation of medical science necessarily drew upon and reinforced local constellations of class, kinship, and religion. Second, it simultaneously reflects upon the expanding genre of homoeopathic biographies published since the mid-nineteenth century: on their features, relevance, and functions, examining in particular the contemporary status of biography vis-à-vis ‘history’ in writing objective pasts.
My 65 years in protein chemistry
Authors: Scheraga Harold A. 
Published: April 2015

AbstractThis is a tour of a physical chemist through 65 years of protein chemistry from the time when emphasis was placed on the determination of the size and shape of the protein molecule as a colloidal particle, with an early breakthrough by James Sumner, followed by Linus Pauling and Fred Sanger, that a protein was a real molecule, albeit a macromolecule. It deals with the recognition of the nature and importance of hydrogen bonds and hydrophobic interactions in determining the structure, properties, and biological function of proteins until the present acquisition of an understanding of the structure, thermodynamics, and folding pathways from a linear array of amino acids to a biological entity. Along the way, with a combination of experiment and theoretical interpretation, a mechanism was elucidated for the thrombin-induced conversion of fibrinogen to a fibrin blood clot and for the oxidative-folding pathways of ribonuclease A. Before the atomic structure of a protein molecule was determined by x-ray diffraction or nuclear magnetic resonance spectroscopy, experimental studies of the fundamental interactions underlying protein structure led to several distance constraints which motivated the theoretical approach to determine protein structure, and culminated in the Empirical Conformational Energy Program for Peptides (ECEPP), an all-atom force field, with which the structures of fibrous collagen-like proteins and the 46-residue globular staphylococcal protein A were determined. To undertake the study of larger globular proteins, a physics-based coarse-grained UNited-RESidue (UNRES) force field was developed, and applied to the protein-folding problem in terms of structure, thermodynamics, dynamics, and folding pathways. Initially, single-chain and, ultimately, multiple-chain proteins were examined, and the methodology was extended to protein–protein interactions and to nucleic acids and to protein–nucleic acid interactions. The ultimate results led to an understanding of a variety of biological processes underlying natural and disease phenomena.
Remembering “txt” but not “text”: The effect of context and lexicality on memory for text message abbreviations
Authors: TAT MICHAEL J. , AZUMA TAMIKO 
Published: April 2015

ABSTRACTText messages often contain abbreviations allowing for an efficient manner to quickly convey content. Although text abbreviations typically contain fewer letters than words, research has demonstrated that they are processed more slowly. Text abbreviations are lexically unique compared to their fully spelled counterparts. This study examined the nature of episodic memory representations for text abbreviations and how top-down contextual information influences the encoding of text abbreviations. In this experiment, participants studied sentences that contained different types of abbreviations: deletions (e.g., tmrw), substitutions (e.g., 2mrw) or “pseudo” abbreviations (e.g., toorow). The sentences were presented within a conversational context or without context. In a recognition memory test, participants saw sentences from the study task that contained either the same abbreviation or a different type of abbreviation. Results revealed that conversational context increased both hits and false recognition rates in the memory test. False recognition rates were generally higher for abbreviation types that shared more surface feature overlap and lower for those that shared less surface feature overlap. The findings suggest text abbreviations have distinct episodic memory representations that incorporate their unique surface feature information and are closely associated to fully spelled lexical memory representations.
Energy content of target and electron flow in femtosecond laser target interactions
Authors: Nardi Eran , Zinamon Zeev , Maron Yitzhak 
Published: April 2015

AbstractThe heating of the titanium foil in a recent femtosecond laser plasma experiment is investigated theoretically in two different ways. In the first, the energy content and thus the heating efficiency of the central volume of the foil is derived by integrating the transverse temperature profiles obtained in this experiment, using specific heats based on the average atom model. In the second approach target heating by the fast electrons, both by direct energy deposition and by resistive heating is investigated. The latter approach makes use of a specially devised electron flow model which includes a simplified quantitative treatment of multi-refluxing as a crucial component. In all, the calculated results of electron beam heating are consistent with experiment within the limitations of the modeling. Finally, a prediction for the temporal dependence of the Kα pulse from the central volume of the foil based on our electron flow model is given.
THz radiation by amplitude-modulated self-focused Gaussian laser beam in ripple density plasma
Authors: Kumar Subodh , Singh Ram Kishor , Singh Monika , Sharma R. P. 
Published: April 2015

AbstractThe effect of self-focusing and defocusing on terahertz (THz) generation by amplitude-modulated Gaussian laser beam in rippled density plasma is investigated. A stronger transient transverse current is generated by transverse component of ponderomotive force exerted by laser on electrons that drives radiation at the modulation frequency (which is chosen to be in the THz domain) because of the variation in intensity in the direction transverse to the laser propagation. Numerical simulations indicate the enhancement of THz yield by many folds due to self-focusing of laser beam in comparison with that without self-focusing. The transient focusing of laser beam and its effect on the generated THz amplitude has also been studied.
Osteoporosis Prescribing in Long-Term Care: Impact of a Provincial Knowledge Translation Strategy
Authors: Kennedy Courtney C. , Ioannidis George , Thabane Lehana , Adachi Jonathan D. , O’Donnell Denis , Giangregorio Lora M. , Pickard Laura E. , Papaioannou Alexandra 
Published: April 2015

RÉSUMÉCette étude décrit les tendances de prescrire avant et après la mise en œuvre d'une stratégie provinciale visant à améliorer la prévention de l'ostéoporose et de la fracture dans les foyers de soins de longue durée (SLD) de l'Ontario. Les données ont été obtenues à partir d'une pharmacie qui a fourni pour 10 centres de SLD en 2007 et 166 foyers en 2012. Nos analyses ont utilisés la régression linéaire multiple et pondérée pour examiner les changements dans les niveaux ou les taux de prescriptions dans les établissements pour la vitamine D, le calcium et les médicaments pour l'ostéoporose de 2007 à 2012. Après cinq ans, l'augmentation des taux estimés pour la prescription de vitamine D, calcium et les médicaments pour l'ostéoporose, respectivement, était de 38,2 pour cent, 4 pour cent et 0,2 pour cent. Bien que l'étude n'a pas évalué la causalité, les résultats suggèrent que les activités à grande échelle dans le transfert des connaissances ont effectué des taux ameliorés de la prescription de vitamine D, bien que des efforts continus sont nécessaires pour cibler les foyers don’t les capacités de traduire les connaissances en pratique sont faibles.
Ethnicity, deprivation and mortality due to 2009 pandemic influenza A(H1N1) in England during the 2009/2010 pandemic and the first post-pandemic season
Authors: ZHAO H. , HARRIS R. J. , ELLIS J. , PEBODY R. G. 
Published: April 2015

SUMMARYThe relationship between risk of death following influenza A(H1N1)pdm09 infection and ethnicity and deprivation during the 2009/2010 pandemic period and the first post-pandemic season of 2010/2011 in England was examined. Poisson regression models were used to estimate the mortality risk, adjusted for age, gender, and place of residence. Those of non-White ethnicity experienced an increased mortality risk compared to White populations during the 2009/2010 pandemic [10·5/1000vs. 6·0/1000 general population; adjusted risk ratio (RR) 1·84, 95% confidence interval (CI) 1·39-2·54] with the highest risk in those of Pakistani ethnicity. However, no significant difference between ethnicities was observed during the following 2010/2011 season. Persons living in areas with the highest level of deprivation had a significantly higher risk of death (RR 2·08, 95% CI 1·49-2·91) compared to the lowest level for both periods. These results highlight the importance of rapid identification of groups at higher risk of severe disease in the early stages of future pandemics to enable the implementation of optimal prevention and control measures for vulnerable populations.
Social cognitive deficits and biases in maltreated adolescents in UK out-of-home care: Relation to disinhibited attachment disorder and psychopathology
Authors: Kay Catherine L. , Green Jonathan M. 
Published: April 2015

AbstractChildren entering out-of-home (OoH) care have often experienced multiple forms of maltreatment and are at risk of psychiatric disorder and poor long-term outcome. Recent evidence shows high rates of disinhibited attachment disorder (DAD) among maltreated adolescents in UK OoH care (Kay & Green, 2013). This study aimed to further understand the mechanisms of outcome in this group through investigation of social cognitive functioning. Patterns of theory of mind (ToM) and social information processing were assessed alongside DAD behavior and psychopathology in 63 adolescents in UK OoH care (mean age = 176 months,SD= 22; 48% male; 89% White British) and 69 low-risk comparison adolescents (mean age = 171 months,SD= 17; 46% male; 87% White British). Compared to low risk, OoH adolescents showed a hostile attribution bias and ToM deficit, but this was confounded by language ability. ToM was associated with reduced hostile attribution and responding biases and increased social competence, which was further associated with lower levels of externalizing psychopathology. There was no association between social cognition and core features of DAD. Social cognitive deficits and biases may play a role in the high rates of externalizing psychopathology and relationship functioning difficulties in maltreated samples. Future research should assess alternative cognitive mechanisms for DAD.
Low-Temperature Cathodoluminescence Investigations of High-Quality Zinc Oxide Nanorods
Authors: Witkowski Bartlomiej S. , Wachnicki Lukasz , Gieraltowska Sylwia , Reszka Anna , Kowalski Bogdan J. , Godlewski Marek 
Published: April 2015

AbstractWe present results of cathodoluminescence (CL) investigations of high-quality zinc oxide (ZnO) nanorods obtained by an extremely fast hydrothermal method on a silicon substrate. A scanning electron microscopy (SEM) system equipped with CL allows direct comparison of SEM images and CL maps, taken from exactly the same areas of samples. Investigations are performed at a temperature of 5 K. An interlink between sample microstructure and emission properties is investigated. CL confirms a very high quality of ZnO nanorods produced by our method. In addition, the presence of super radiation effects in ZnO nanorod arrays is suggested.
The role of portable electric fencing in biodiversity-friendly pasture management
Authors: Morgan Nickele B. 
Published: April 2015

AbstractWorld population is growing, and with it, the demand for food. In order to feed the world and attempt to slow the biodiversity crisis on the planet, farming practices must be altered to preserve species richness and ecological health. The fertile soil found in grassland biomes throughout the world provides a base for rich microorganism biodiversity, carbon sequestration, as well as water and nutrient cycling. Diverse biological communities are found in both natural and semi-natural grasslands; habitat destruction as a result of agricultural practices is a threat to biodiversity in these regions. While critics often blame modernized farming practices for agricultural pollution and habitat fragmentation, 21st century technology will likely be a means for updating farming practices to address both biodiversity conservation and enhanced efficiency for increased food demand. Recently developed portable electric fences, made of plastic netting and stainless steel, have made eco-agricultural practices, such as rotational grazing (RG) and multi-species pasture systems, easier and less expensive for farmers to put into practice than traditional electric fencing. Conflicting literature exists regarding whether or not RG systems outperform continuous grazing systems. Many studies suggest that more research is needed to observe the ecological benefits of RG on active farmland. Portable electric fences could be a valuable tool for completing additional research.
Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy
Authors: Mizrachi Dario , Chen Yujie , Liu Jiayan , Peng Hwei-Ming , Ke Ailong , Pollack Lois , Turner Raymond J. , Auchus Richard J. , DeLisa Matthew P. 
Published: April 2015

AbstractIntegral membrane proteins (IMPs) play crucial roles in all cells and represent attractive pharmacological targets. However, functional and structural studies of IMPs are hindered by their hydrophobic nature and the fact that they are generally unstable following extraction from their native membrane environment using detergents. Here we devise a general strategy for in vivo solubilization of IMPs in structurally relevant conformations without the need for detergents or mutations to the IMP itself, as an alternative to extraction and in vitro solubilization. This technique, called SIMPLEx (solubilization of IMPs with high levels of expression), allows the direct expression of soluble products in living cells by simply fusing an IMP target with truncated apolipoprotein A-I, which serves as an amphipathic proteic ‘shield’ that sequesters the IMP from water and promotes its solubilization.
A pyrosequencing insight into sprawling bacterial diversity and community dynamics in decaying deadwood logs of Fagus sylvatica and Picea abies
Authors: Hoppe Björn , Krüger Dirk , Kahl Tiemo , Arnstadt Tobias , Buscot François , Bauhus Jürgen , Wubet Tesfaye 
Published: April 2015

AbstractDeadwood is an important biodiversity hotspot in forest ecosystems. While saproxylic insects and wood-inhabiting fungi have been studied extensively, little is known about deadwood-inhabiting bacteria. The study we present is among the first to compare bacterial diversity and community structure of deadwood under field conditions. We therefore compared deadwood logs of two temperate forest tree species Fagussylvatica and Piceaabies using 16S rDNA pyrosequencing to identify changes in bacterial diversity and community structure at different stages of decay in forest plots under different management regimes. Alphaproteobacteria, Acidobacteria and Actinobacteria were the dominant taxonomic groups in both tree species. There were no differences in bacterial OTU richness between deadwood of Fagussylvatica and Piceaabies. Bacteria from the order Rhizobiales became more abundant during the intermediate and advanced stages of decay, accounting for up to 25% of the entire bacterial community in such logs. The most dominant OTU was taxonomically assigned to the genus Methylovirgula, which was recently described in an experiment of Fagussylvatica woodblocks. Besides tree species we were able to demonstrate that deadwood physico-chemical properties, in particular remaining mass, relative wood moisture, pH and C/N ratio serve as drivers of community composition of deadwood-inhabiting bacteria.
Magnetization Transfer Imaging of Suicidal Patients with Major Depressive Disorder
Authors: Chen Ziqi , Zhang Huawei , Jia Zhiyun , Zhong Jingjie , Huang Xiaoqi , Du Mingying , Chen Lizhou , Kuang Weihong , Sweeney John A. , Gong Qiyong 
Published: April 2015

AbstractMagnetization transfer imaging (MTI) provides a quantitative measure of the macromolecular structural integrity of brain tissue, as represented by magnetization transfer ratio (MTR). In this study, we utilized MTI to identify biophysical alterations in MDD patients with a history of suicide attempts relative to MDD patients without such history. The participants were 36 medication-free MDD patients, with (N = 17) and without (N = 19) a history of a suicide attempt and 28 healthy controls matched for age and gender. Whole brain voxel-based analysis was used to compare MTR across three groups and to analyze correlations with symptom severity and illness duration. We identified decreased MTR in left inferior parietal lobule and right superior parietal lobule in suicide attempters relative to both non-attempters and controls. Non-attempters also showed significantly reduced MTR in left inferior parietal lobule relative to controls, as well as an MTR reduction in left cerebellum. These abnormalities were not correlated with symptom severity or illness duration. Depressed patients with a history of suicide attempt showed bilateral abnormalities in parietal cortex compared to nonsuicidal depressed patients and healthy controls. Parietal lobe abnormalities might cause attentional dysfunction and impaired decision making to increase risk for suicidal behavior in MDD.
A rapid and reliable strategy for chromosomal integration of gene(s) with multiple copies
Authors: Gu Pengfei , Yang Fan , Su Tianyuan , Wang Qian , Liang Quanfeng , Qi Qingsheng 
Published: April 2015

AbstractDirect optimization of the metabolic pathways on the chromosome requires tools that can fine tune the overexpression of a desired gene or optimize the combination of multiple genes. Although plasmid-dependent overexpression has been used for this task, fundamental issues concerning its genetic stability and operational repeatability have not been addressed. Here, we describe a rapid and reliable strategy for chromosomal integration of gene(s) with multiple copies (CIGMC), which uses the flippase from the yeast 2-μm plasmid. Using green fluorescence protein as a model, we verified that the fluorescent intensity was in accordance with the integration copy number of the target gene. When a narrow-host-range replicon, R6K, was used in the integrative plasmid, the maximum integrated copy number of Escherichia coli reached 15. Applying the CIGMC method to optimize the overexpression of single or multiple genes in amino acid biosynthesis, we successfully improved the product yield and stability of the production. As a flexible strategy, CIGMC can be used in various microorganisms other than E. coli.
Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition
Authors: Shi Xianping , Lan Xiaoying , Chen Xin , Zhao Chong , Li Xiaofen , Liu Shouting , Huang Hongbiao , Liu Ningning , Zang Dan , Liao Yuning , Zhang Peiquan , Wang Xuejun , Liu Jinbao 
Published: April 2015

AbstractResistance to chemotherapy is a great challenge to improving the survival of patients with diffuse large B-cell lymphoma (DLBCL), especially those with activated B-cell-like DLBCL (ABC-DLBCL). Therefore it is urgent to search for novel agents for the treatment of DLBCL. Gambogic acid (GA), a small molecule derived from Chinese herb gamboges, has been approved for Phase II clinical trial for cancer therapy by Chinese FDA. In the present study, we investigated the effect of GA on cell survival and apoptosis in DLBCL cells including both GCB- and ABC-DLBCL cells. We found that GA induced growth inhibition and apoptosis of both GCB- and ABC-DLBCL cells in vitro and in vivo, which is associated with proteasome malfunction. These findings provide significant pre-clinical evidence for potential usage of GA in DLBCL therapy particularly in ABC-DLBCL treatment.
Potent effects of dioscin against liver fibrosis
Authors: Zhang Xiaoling , Han Xu , Yin Lianhong , Xu Lina , Qi Yan , Xu Youwei , Sun Huijun , Lin Yuan , Liu Kexin , Peng Jinyong 
Published: April 2015

AbstractWe previously reported the promising effects of dioscin against liver injury, but its effect on liver fibrosis remains unknown. The present work investigated the activities of dioscin against liver fibrosis and the underlying molecular mechanisms. Dioscin effectively inhibited the cell viabilities of HSC-T6, LX-2 and primary rat hepatic stellate cells (HSCs), but not hepatocytes. Furthermore, dioscin markedly increased peroxisome proliferator activated receptor-γ (PPAR-γ) expression and significantly reduced a-smooth muscle actin (α-SMA), transforming growth factor-β1 (TGF-β1), collagen α1 (I) (COL1A1) and collagen α1 (III) (COL3A1) levels in vitro. Notably, dioscin inhibited HSCs activation and induced apoptosis in activated HSCs. In vivo, dioscin significantly improved body weight and hydroxylproline, laminin, α-SMA, TGF-β1, COL1A1 and COL3A1 levels, which were confirmed by histopathological assays. Dioscin facilitated matrix degradation and exhibited hepatoprotective effects through the attenuation of oxidative stress and inflammation, in addition to exerting anti-fibrotic effects through the modulation of the TGF-β1/Smad, Wnt/β-catenin, mitogen-activated protein kinase (MAPK) and mitochondrial signaling pathways, which triggered the senescence of activated HSCs. In conclusion, dioscin exhibited potent effects against liver fibrosis through the modulation of multiple targets and signaling pathways and should be developed as a novel candidate for the treatment of liver fibrosis in the future.