bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐control study on reduced‐dose depot versus daily administration of gonadotrophin‐releasing hormone agonists for pituitary desensitization in in vitro fertilization cycles
Authors: Gao Jun , Xu Yan‐Wen , Miao Ben‐Yu , Zhou Can‐Quan 
Published: July 2014

AbstractAimOur aim was to analyze the effect of reducing the dose of depot gonadotrophin‐regulating hormone‐agonist (GnRH‐a) to 1.0 mg on pituitary desensitization and clinical outcome of in vitro fertilization and embryo transfer cycles.Material and MethodsThis retrospective self‐control study was conducted on 143 patients who underwent repeated long‐protocol treatment from 1 January 2011 to 31 May 2012 at our hospital. Of the 143 patients, 64 received reduced‐dose depot (1.0 mg diphereline depot) GnRH‐a for the first cycle and short‐acting GnRH‐a (0.05 mg diphereline) for the second cycle, while 79 patients received short‐acting GnRH‐a for the first cycle and reduced‐dose depot GnRH‐a for the second cycle.ResultsThe serum follicle‐stimulating hormone, luteinizing hormone and estradiol levels on the day of gonadotrophin initiation were significantly higher in the short‐acting group compared with the long‐acting group. Both number of days of gonadotrophin stimulation and gonadotrophin doses were significantly higher in the short‐acting group. On the day of human chorionic gonadotrophin administration, the serum estradiol level was significantly higher while the progesterone level was significantly lower in the short‐acting group. There were no significant differences with regard to the number of retrieved oocytes, fertilization rate, number of transferred embryos, clinical pregnancy rate, implantation rate, and early pregnancy loss rate between the two groups. However, the oocyte maturation rate was significantly higher in the long‐acting group.ConclusionReduced‐dose depot GnRH‐a can be successfully used for pituitary desensitization in in vitro fertilization and embryo transfer. Deeper downregulation with reduced‐dose depot GnRH‐a indicates that the optimal dose of GnRH‐a warrants future study.
Extracorporeal membrane oxygenation saved a mother and her son from fulminant peripartum cardiomyopathy
Authors: Park Sang Hyun , Chin Jung Yeon , Choi Min Suk , Choi Jin Ho , Choi Yu Jeong , Jung Kyung Tae 
Published: July 2014

AbstractA 34‐year‐old full‐term pregnant woman presented with abruptly aggravating dyspnea. A chest X‐ray showed pulmonary edema, and an echocardiogram revealed a left ventricular ejection fraction of 39%. Despite conventional medical treatment for acute heart failure and mechanical ventilation, hypoxia and metabolic acidosis were aggravated, and the fetal heart rate decreased to 90 b.p.m., suggestive of fetal distress. We decided to initiate extracorporeal membrane oxygenation (ECMO) and perform a cesarean section. The infant was successfully delivered without hypoxic brain damage. The patient was weaned from ECMO 6 days after delivery and was extubated 1 day after discontinuation of ECMO. Left ventricular systolic function had completely recovered at this time. This is the first report of a patient with peripartum cardiomyopathy who had a successful delivery with the support of ECMO, demonstrating that ECMO can serve as a rescue therapy, not only treating peripartum cardiomyopathy but also permitting a safe delivery.
Novel reversible permanent contraception: An animal experiment of embedding contraceptive surgery in the fimbriated extremity of the fallopian
Authors: Xin Gang , Du Juan , Zhang Jun , Xu YongPing 
Published: July 2014

AbstractAimAccording to female pelvic anatomical characteristics, we designed a novel reversible permanent contraception: embedding contraceptive surgery in the fimbriated extremity of the fallopian. This study involves embedding the oviduct of New Zealand rabbits into the peritoneum, and assesses contraceptive effect, morphological changes and recoverability.MethodsThirty New Zealand rabbits were divided into three groups: embedding in the fimbriated extremity of the fallopian group (A group); polyethylene film in the fimbriated extremity of the fallopian group (B group); and control (C group). Surgery was performed in each group, respectively. Contraceptive efficacy, morphological changes and recoverability were noted.ResultsAs for contraceptive effect, mating experiences were successful. After 3 months, there were no pregnant rabbits in group A and B, while in group C all samples were pregnant. Regarding recoverability, after belly operation, 10 rabbits in group A showed dropsy in the bilateral oviducts. Tissue adhesion could be found in the fimbriated extremity of the fallopian with a large range of damage. All samples in group B also had dropsy, but only two of them had unilateral slight adhesions in the fimbriated extremity of the fallopian, while others had no pathological changes. After being released from the oviduct embedding, five rabbits in group A became pregnant and nine in group B.ConclusionEmbedding contraceptive surgery in the fimbriated extremity of the fallopian after being covered by polyethylene film is reliable and safe. Releasing the embedding may cause minor injury. Although there is a problem of hydrosalpinx, the pregnancy rate is high.
Comparison between two incision angles of mediolateral episiotomy in primiparous women: A randomized controlled trial
Authors: El‐Din Adel S. S. , Kamal Magdy M. , Amin Malaka A. 
Published: July 2014

AbstractAimTo compare two incision angles (60° vs 40°) of mediolateral episiotomy in primiparous Egyptian women, regarding the incidence of anal sphincter injury as well as episiotomy‐related pain and dyspareunia.MethodsThe current prospective randomized controlled trial (ClinicalTrials.gov, NCT01930721) was conducted at Ain Shams University Maternity Hospital. Eligible women were randomized into two groups: group 1 included women who had the episiotomy incision made at an angle of 60° to the midline; and group 2 included women who had the episiotomy incision made at an angle of 40° to the midline. Primary outcome measures were differences in short‐term related pain and rate of third/fourth degree perineal tears.ResultsA total of 330 primiparous women were recruited. The shortest distance to the outer edge of the anal epithelium was significantly shorter in women of group 2 when compared to that in women of group 1. Out of the included 330 women, 13 (4%) had third/fourth‐degree perineal tears (4 [2.4%] in group 1 in contrast to nine [5.5%] in group 2). This difference was not significant A 60°‐angled mediolateral episiotomy was associated with significantly higher rates of moderate/severe episiotomy‐related pain post‐partum. The rates of moderate/severe episiotomy‐related pain and dyspareunia assessed 6 months post‐partum were also higher among women of group 1, when compared to group 2; the latter two differences did not reach statistical significance, however.ConclusionWhen compared to the 40°‐angled mediolateral episiotomies, 60°‐angled ones were associated with significantly higher short‐term‐related pain. Although they were also associated with lower rate of third/fourth‐degree perineal tears and higher rate of long‐term related pain and dyspareunia, these differences did not reach a statistically significant level.
Obstetric and neonatal outcomes of delayed interval delivery in cerclage and non‐cerclage cases: An analysis of 20 multiple pregnancies
Authors: Doger Emek , Cakiroglu Yigit , Ceylan Yasin , Kole Emre , Ozkan Sebiha , Caliskan Eray 
Published: July 2014

AbstractAimThe aim of study is to compare maternal and fetal outcomes of pregnancies in which cerclage was placed following the loss of first fetus with those without cerclage placement in multiple pregnancies for delayed interval delivery.MethodsRecords of pregnancies in which the first fetus was lost between 13–26 weeks and delayed delivery experienced for retained fetus(es), were collected retrospectively. A total of 20 patients including 11 twins, seven triplets and two quadruplets were evaluated. Cases with cervical cerclage placed after the first delivery were evaluated as the cerclage group (n = 11) and the cases without cerclage placement were evaluated as the non‐cerclage group (n = 9).ResultsMedian duration of delay was 22 days (range, 3–121) for both groups; 40 days (range, 5–121) in cerclage group and 12 days (range, 3–46) in the non‐cerclage group (P = 0.003). Average birthweight of retained fetus(es) in the cerclage group was 850 ± 153.6 g (mean ± standard error [SE]) and 549.5 ± 149.1 g (mean ± SE) in the non‐cerclage group (P = 0.04). Delivery week of retained fetus(es), live birth rate, take‐home baby rate and chorioamnionitis ratio were not different in between the groups.ConclusionCervical cerclage after the first delivery is associated with a longer delivery interval and higher birthweight of retained fetus.
Different subsets of Langerhans cells in human uterine tubes and uterus
Authors: Rabi Suganthy , Jacob Tripti Meriel , Lionel Jessie , Indrasingh Inbam 
Published: July 2014

AbstractAimLangerhans cells (LC) are antigen‐presenting cells present in tissues with high antigenic exposure. Their role in the upper female reproductive tract is not fully understood. This study aims to determine the distribution and morphology of LC in the normal and post‐partum human uterine tubes and uterus by staining with the specific LC markers, CD1a and zinc iodide‐osmium (ZIO), and to determine their association with helper and cytotoxic T cells.Material and MethodsNormal and post‐partum uterine tube and uterine specimens were stained with CD1a and ZIO and their morphology and distribution noted. Double immune staining with CD1a‐CD4 and CD1a‐CD8 in post‐partum uterine tube were also done.ResultsIt was noted that CD1a‐positive cells were significantly fewer and smaller in diameter than ZIO‐positive cells in the uterine tube and both types of cells were significantly more prevalent in post‐partum tubes. Perivascular clusters of ZIO‐positive cells were seen in the post‐partum tubes. Close association of CD1a‐positive cells with CD4‐ and CD8‐positive T cells was noted in the post‐partum uterine tube. In the uterus, scanty CD1a‐positive cells were present in the surface and glandular epithelium and endometrial stroma. ZIO‐positive cells were absent.ConclusionThis study suggests that CD1a‐positive and ZIO‐positive cells may be different subsets of LC that are needed for presentation of antigen to immunocompetent cells. Their respective functions are yet to be determined.
Expression of glucose transporter protein 1 and p63 in serous ovarian tumor
Authors: Cai Yu , Zhai Jian‐jun , Feng Bi‐bo , Duan Xian‐zhi , He Xiao‐jin 
Published: July 2014

AbstractAimIt has been shown that glycolytic metabolism is increased in malignant cells. Cancer cell growth is an energy‐related process supported by an increased glucose metabolism. In addition, p63, a known homolog of p53, is expressed predominantly in basal cell and squamous cell carcinomas. The purpose of this study was to evaluate the expression of glucose transporter protein 1 (GLUT1) and p63 in patients with serous ovarian tumor (benign, borderline and malignant) and study their close relationship with the malignant transformation of serous ovarian tumors.MethodsTwo hundred formalin‐fixed, paraffin‐embedded sections were immunostained with rabbit anti‐GLUT1 polyclonal antibody and mouse anti‐p63 monoclonal antibody using the streptavidin‐biotin method. The samples were as follows: 40 normal ovarian tissues, 40 serous cystadenomas, 40 borderline serous cystadenomas and 80 serous cystadenocarcinomas were stained.ResultNormal ovarian tissues showed completely negative staining for GLUT1 and p63. However, from benign serious cystadenomas, borderline cystadenomas to cystadenocarcinomas, the expression of GLUT1 and p63 grew stronger (P < 0.05). Moreover, the intensity staining of GLUT1 maintained a significant association with the expression of p63 (P < 0.05). In χ2‐test analysis, expression of borderline cystadenomas and cystadenocarcinomas, intraperitoneal implants, ascites, lymph node status and International Federation of Gynecology and Obstetrics (FIGO) stage and GLUT1 expression levels have an appalling significance (P < 0.05), while FIGO stage, intraperitoneal implants and lymph node status except patient age and ascites have a statistical significance with the expression of p63 levels (P < 0.05).ConclusionOur findings show a progressive increase in the expression of GLUT1 and p63 from the benign serous cystadenomas, borderline cystadenomas to cystadenocarcinomas. Overexpression of GLUT1 and p63 are associated with the histology FIGO stage and metastasis of the tumors. These data suggested that the expression of GLUT1 and p63 may be closely related to the malignant transformation of serous ovarian tumors. However, the relative importance of GLUT1 and p63 in ovarian serous tumor development and tumorigenesis remains mostly unclear and awaits further investigation.
Coring‐type laparoscopic resection of a cavitated non‐communicating rudimentary horn under hysteroscopic assistance
Authors: Akdemir Ali , Ergenoglu Ahmet Mete , Yeniel Ahmet Özgür , Sendag Fatih , Karadadaş Nedim 
Published: July 2014

AbstractNon‐communicating accessory uterine horns with an endometrial cavity are the most common and clinically significant unicornuate subtype of Müllerian duct abnormality. They are generally associated with symptoms of dysmenorrhea, dyspareunia, infertility, endometriosis, adhesions, and life‐threatening cornual pregnancy. Treatment options include surgical resection of the rudimentary horn, hysteroscopic recanalization, and endometrial ablation. Currently, laparoscopic resection is the recommended treatment choice. Dissection of the rudimentary horn from the unicornuate uterus is the most challenging part of this procedure and may compromise the remaining unicornuate uterus wall. Here we describe a case of laparoscopic coring‐type resection of a non‐communicating functional rudimentary horn firmly attached to the unicornuate uterus, by using hysteroscopic assistance. The use of hysteroscopy, adjunct to laparoscopy, facilitates the coring‐type resection and may strengthen the remaining myometrial scar.
Assessment of sub‐endometrial blood flow parameters following dydrogesterone and micronized vaginal progesterone administration in women with idiopathic recurrent miscarriage: A pilot study
Authors: Ghosh Sanghamitra , Chattopadhyay Ratna , Goswami Sourendrakanta , Chaudhury Koel , Chakravarty Baidyanath , Ganesh Ashalatha 
Published: July 2014

AbstractAimTo evaluate differences in uteroplacental blood flow and pregnancy outcome in women with idiopathic recurrent spontaneous miscarriage (IRSM) following administration of micronized vaginal progesterone and oral dydrogesterone.MethodsOne hundred and thirty‐three women (aged 23–40 years) who had had early miscarriages and spontaneous conception participated. Oral dydrogesterone (group A, n = 51) and micronized vaginal progesterone (group B, n = 50) were administrated for luteal support and compared. Pregnant women without history of recurrent miscarriage served as controls (group C, n = 32). The outcome measures consisted of endometrial blood flow parameters by Doppler indices and ongoing pregnancy rate.ResultsBefore progesterone supplementation, resistivity index (RI) and pulsatility index (PI) were found to be significantly higher in groups A and B as compared to controls. Although statistically not significant, end diastolic velocity (EDV) and systolic/diastolic (S/D) ratio was found to be superior in controls than IRSM women. Peak systolic velocity (PSV) was comparable between IRSM and non‐IRSM groups. Following progesterone supplementation, groups A and B showed a highly significant reduction in RI, PI and an increase in EDV. A relative increase in the value of PSV was observed in group A as compared to group B. There was remarkable difference in S/D in both groups. Although not statistically significant, group C showed reduction in RI, PI, PSV, EDV and S/D ratio. Pregnancy salvage rates were higher in group A (92.0%) as compared to group B (82.3%).ConclusionProgesterone supplementation appears to lower vascular resistance in women with IRSM. Oral dydrogesterone appears to be equally effective in improving endometrial blood flow as compared with micronized progesterone.
Bilateral Optic Neuropathy with Bilateral Putaminal Lesions: A Case Report
Authors: Togawa Jumpei , Ohi Takekazu 
Published: July 2014

ABSTRACTBilateral optic neuropathy with bilateral putaminal lesions may be caused by methanol or cyanide poisoning or mitochondrial disorders including Leber hereditary optic neuropathy and Leigh syndrome. We report the case of a 34‐year‐old Japanese man who developed bilateral visual loss 5 days after the development of gastrointestinal symptoms. Magnetic resonance imaging of the brain on admission revealed high‐intensity signal areas in the bilateral putamina on diffusion‐weighted and T2‐weighted images as well as a high‐intensity signal area in the left middle cerebellar peduncle that had been identified 3 years previously. We diagnosed bilateral optic neuropathy with bilateral putaminal lesions caused by preceding infection‐triggered demyelination. We administered methylprednisolone, but his vision did not recover.
Further Definition on the Multiple Partner Choice Arena: A Potential Animal Model for the Study of Premature Ejaculation
Authors: Olayo-Lortia Jesús , Ferreira-Nuño Armando , Velázquez-Moctezuma Javier , Morales-Otal Adriana 
Published: July 2014

Abstract

Introduction
The multiple partner choice arena (MPCA) is an experimental setup in which male rats display a significant shortening of ejaculation latency, which is the main characteristic of premature ejaculation (PE) in men. Thus, the MPCA is a potential animal model for PE.

Aim
In this study, we further analyze whether the features of the MPCA satisfy the validity criteria for it to be considered an animal model as well as the possible participation of the serotoninergic system in the faster ejaculation exhibited by male rats in the MPCA.

Methods
In Experiment 1, male rats were tested in a standard arena to assess their sexual behavior, then were assessed 1 week later in the MPCA. Another group was first tested in the MPCA, then in a standard arena. In Experiment 2, male rats divided into two groups were treated daily with WAY-100635 (5-HT1A antagonist) or vehicle for 15 days. In each group, half of the subjects were tested in a standard arena and half were tested in the MPCA on days 1, 8, and 15 of treatment.

Main Outcome Measures
Number of intromissions and intromission and ejaculation latencies were the main outcome measures.

Results
In Experiment 1, males tested in the MPCA ejaculated significantly faster, regardless of the order in which they were evaluated in both arenas. In Experiment 2, the administration of WAY-100635 increased intromission and ejaculation latencies, and the number of intromissions in the MPCA.

Conclusions
The results obtained in the MPCA support its use as an animal model for PE evaluation.
Association of Quantity and Duration of Smoking with Erectile Dysfunction: A Dose–Response Meta-Analysis
Authors: Cao Shiyi , Gan Yong , Dong Xiaoxin , Liu Junan , Lu Zuxun 
Published: July 2014

Abstract

Introduction
Some original studies and a recent meta-analysis suggested that smoking could be associated with the risk of erectile dysfunction (ED), but the dose–response relationship between them was unclear.

Aim
The aim of this study was to investigate the potential association between quantity and duration of smoking and the risk of ED.

Methods
We conducted a literature search of PubMed, Embase, Web of Science, and Scopus from these databases' inception through March 2014 for observational epidemiological studies examining the association between smoking and risk of ED. Random-effects meta-analyses were used to combine the results of included studies.

Main Outcome Measure
Quantitative review of published observational epidemiological studies on the association between smoking and risk of ED was the main outcome measure.

Results
One cohort study and nine cross-sectional studies were eligible for inclusion in the meta-analysis (50,360 participants and 12,218 cases with ED). No evidence of a curve linear association was observed between smoking and risk of ED. The summary odds ratio of ED for an increase of 10 cigarettes smoked per day was 1.14 (95% confidence interval 1.09 to 1.18), with moderate heterogeneity (P = 0.061, I 2 = 44.7%). For an increment of 10 years of smoking, the combined odds ratios of ED was 1.15 (95% confidence interval 1.10 to 1.19), without substantial heterogeneity (P = 0.522, I 2 = 0.0%).

Conclusions
Evidence from observational studies suggests that there is a positive dose–response association between quantity and duration of smoking and risk of ED.
Comparison of Manual and Suction Pump Aspiration Techniques for Performing Bronchoalveolar Lavage in 18 Dogs with Respiratory Tract Disease
Authors: Woods K.S. , Defarges A.M.N. , Abrams‐Ogg A.C.G. , Viel L. , Brisson B.A. , Bienzle D. 
Published: July 2014

BackgroundDifferent aspiration techniques to retrieve bronchoalveolar lavage fluid (BALF) affect sample quality in healthy dogs. Studies evaluating these techniques in dogs with respiratory disease are lacking.ObjectivesTo compare sample quality ofBALFacquired by manual aspiration (MA) and suction pump aspiration (SPA).AnimalsEighteen client‐owned dogs with respiratory disease.MethodsRandomized, blinded prospective clinical trial. Manual aspiration was performed with a 35‐mL syringe attached directly to the bronchoscope biopsy channel andSPAwas performed with a maximum of 50 mmHg negative pressure applied to the bronchoscope suction valve using the suction trap connection. Both aspiration techniques were performed in each dog on contralateral lung lobes, utilizing 2 mL/kg lavage volumes per site. Samples ofBALFwere analyzed by percentage of retrieved infusate, total nucleated cell count (TNCC), differential cell count, semiquantitative assessment of slide quality, and diagnosis score. Data were compared by paired Student'st‐test, Wilcoxon signed‐rank test, chi‐squared test, and ANOVA. Cohen's kappa coefficient was used to assess agreement.ResultsThe percentage of retrievedBALF(P = .001) was significantly higher forSPAthanMA. Substantial agreement was found between cytologic classification ofBALFobtained withMAandSPA(kappa = 0.615). There was no significant difference in rate of definitive diagnosis achieved with cytologic assessment between techniques (P = .78).Conclusions and Clinical ImportanceSuction pump aspiration, compared toMA, improvedBALFretrieval, but did not significantly affect the rate of diagnostic success of bronchoalveolar lavage (BAL) in dogs with pulmonary disease.