bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Asset Pricing Models Explain Size, Value, Momentum and Liquidity Effects? The Case of an Emerging Stock Market
Authors: Dash Saumya Ranjan , Mahakud Jitendra 
Published: December 2014

This article examines whether the alternative asset pricing models and more specifically the liquidity-augmented multifactor models can explain the effect of size, value, momentum and liquidity on cross section of stock returns in India during September 1995 to March 2011. We employ time series and panel data methodology to carry out the analysis. Our findings suggest that the value and liquidity effects are often explained, but the explanatory power of size and short-run past return or momentum effect remain consistent irrespective of alternative asset pricing models risk adjustment process. The liquidity-augmented multifactor models are found to have better explanatory power than to the other alternative multifactor models. The relative performance of liquidity-augmented multifactor modes for capturing the role of firm characteristics on stock returns varies across the individual firms’ liquidity sensitivity and the aggregate market liquidity conditions. JEL Classification: G11, G12, G14, G15
The Influence of E-disclosure on the Ex-Ante Cost of Capital of Listed Companies in Brazil
Authors: Mendes-Da-Silva Wesley , Onusic Luciana Massaro , Bergmann Daniel Reed 
Published: December 2014

The aim of this article is to show the existence of a relationship between voluntary disclosure via corporate websites and the ex-ante cost of capital of companies listed on the BM&FBovespa. Ordinary least-squares regression equations produced the following results: (a) on average, the companies listed on the New Market showed a lower cost of capital (≈3.3 percentage points lower); (b) on average, the companies deemed to be the most aggressive showed a higher cost of capital (≈3 percentage points higher than the conservative companies); and (c) the metrics of corporate website disclosure did not appear to be related to cost of capital. JEL Classification: E32, E44, G31, G32
Regime-Switching Behaviour in the Conditional Volatility of MENA Stock Market Returns
Authors: Bahloul Slah , Abid Fathi 
Published: December 2014

The objective of this article is to investigate the behaviour of the time-varying volatility in 11 Middle East and North African (MENA) countries’ stock market using a three-state Markov regime switching model over the period from 30 October 2006 to 21 October 2011. We find that MENA stock market volatility can be characterised by three regimes: tranquil period with low volatility of volatility, turmoil regime with high volatility of volatility and crisis regime with extremely high volatility of volatility. Besides, the Granger causation effects from the MSCI World index to MENA stock markets are stronger and statistically significant especially in crisis regime. JEL Classification: F30, G01, G15
Mural art therapy for young offenders hospitalised with a mental illness
Authors: George Oleen , Kasinathan John 
Published: December 2014

Objective: To describe a mural art therapy project completed within an adolescent unit of a secure forensic psychiatric hospital. Method: The planning, implementation and consecutive stages of the mural art therapy project are described. Pertinent themes are identified. Results: A cohort of adolescent forensic inpatients was engaged in a group therapeutic process involving collaboration, design and the completion of an art mural. The participants generally approved of the project and identified themes of gaining a sense of achievement, empowerment, teamwork, involvement and ownership. The art mural transformed and improved the visual and spatial environment of the Adolescent unit courtyard. Conclusions: Mural art therapy was acceptable to young offenders hospitalised with mental illness, which has relevance for adolescent psychiatric units and youth detention centres.
A guide to clinical research supervision for psychiatrists: a mentoring approach
Authors: Looi Jeffrey C , Kisely Steve , Macfarlane Matthew D , Siskind Dan , Smith Geoff , Macfarlane Stephen 
Published: December 2014

Objectives: To provide a guide for clinically-based psychiatrist supervisors of research projects for early career researchers. Methods: This paper will describe a mentoring framework for supervision, for psychiatrist clinical research supervisors and early career researchers. Results: The domains discussed include, across various aspects of a study: the role of the supervisor, project management, and where and when to seek advice. Conclusions: Supervision of clinical research can be a professionally rewarding experience for psychiatrists, as well as early career researcher supervisees.
Ethical Thinking and Sustainability in Role-Play Participants
Authors: Schrier Karen 
Published: December 2014

Purpose. Can games provide a holistic understanding of the ethical decision-making process related to sustainability and environmental management? Method. Thirty participants, 18 to 34 years old, were recruited. Twenty were then randomly assigned to play a popular role-playing game, which raises an issue of whether to drain or preserve a virtual lake. Ten participants were assigned to a control condition, which involved a written version of the lake dilemma. Using a researcher-developed coding scheme, this study compared the ethical thinking skills and thought processes used to approach the lake scenario. Findings.Control condition participants more frequently chose to drain the lake than game condition participants. The top-ranked thought processes used by the control condition participants were reasoning-related only, whereas the top-ranked thought processes used by the game condition participants were both reasoning- and empathy-related, which may have related to their greater likelihood to preserve the lake. While, most game participants chose to preserve the lake (75%), game participants chose the “negative” choice in this scenario more often than any other (non-sustainability related) scenario provided in the game. Implications. This study helps us to understand how people think through sustainability-related scenarios, and how to use games for policy making and education.
Virtues of Violence
Authors: Walsh Aylwyn , Tsilimpounidi Myrto 
Published: December 2014

This is a performance of statements/records/made up lies. We collected testimonies that spoke of some of the violences that we are facing—from Greece and Turkey—but these glimpses of frustration, bruising, broken dreams are evident everywhere, with different masks and excuses: “neoliberalism”/“extremism”/“unionism.” All have the common suggestion: that this is how we play the game. The mediated moral panic about urban insurrections demonstrates how insidious representations of violence are at once everyday and ideologically driven. This text of a performance lecture offers an intimate, embodied consideration of the problem of violence and its representations. The texts from each city (Athens and Istanbul) became scripts for presenting and representing the ways public and private, nation and terror, Self and Other are negotiated. We investigated the nature of violence in protests in both cities with the aim of presenting the findings through performance.
Comparative Performance Assessment of Point-of-Care Testing Devices for Measuring Glucose and Ketones at the Patient Bedside
Authors: Ceriotti Ferruccio , Kaczmarek Ewa , Guerra Elena , Mastrantonio Fabrizio , Lucarelli Fausto , Valgimigli Francesco , Mosca Andrea 
Published: December 2014

Background: Point-of-care (POC) testing devices for monitoring glucose and ketones can play a key role in the management of dysglycemia in hospitalized diabetes patients. The accuracy of glucose devices can be influenced by biochemical changes that commonly occur in critically ill hospital patients and by the medication prescribed. Little is known about the influence of these factors on ketone POC measurements. The aim of this study was to assess the analytical performance of POC hospital whole-blood glucose and ketone meters and the extent of glucose interference factors on the design and accuracy of ketone results. Methods: StatStrip glucose/ketone, Optium FreeStyle glucose/ketone, and Accu-Chek Performa glucose were also assessed and results compared to a central laboratory reference method. The analytical evaluation was performed according to Clinical and Laboratory Standards Institute (CLSI) protocols for precision, linearity, method comparison, and interference. Results: The interferences assessed included acetoacetate, acetaminophen, ascorbic acid, galactose, maltose, uric acid, and sodium. The accuracies of both Optium ketone and glucose measurements were significantly influenced by varying levels of hematocrit and ascorbic acid. StatStrip ketone and glucose measurements were unaffected by the interferences tested with exception of ascorbic acid, which reduced the higher level ketone value. The accuracy of Accu-Chek glucose measurements was affected by hematocrit, by ascorbic acid, and significantly by galactose. The method correlation assessment indicated differences between the meters in compliance to ISO 15197 and CLSI 12-A3 performance criteria. Conclusions: Combined POC glucose/ketone methods are now available. The use of these devices in a hospital setting requires careful consideration with regard to the selection of instruments not sensitive to hematocrit variation and presence of interfering substances.
Evaluation of the Length and Isometric Pattern of the Anterolateral Ligament With Serial Computer Tomography
Authors: Helito Camilo Partezani , Helito Paulo Victor Partezani , Bonadio Marcelo Batista , da Mota e Albuquerque Roberto Freire , Bordalo-Rodrigues Marcelo , Pecora Jose Ricardo , Camanho Gilberto Luis , Demange Marco Kawamura 
Published: December 2014

Background: Recent anatomical studies have identified the anterolateral ligament (ALL). Injury to this structure may lead to the presence of residual pivot shift in some reconstructions of the anterior cruciate ligament. The behavior of the length of this structure and its tension during range of motion has not been established and is essential when planning reconstruction. Purpose: To establish differences in the ALL length during range of knee motion. Study Design: Descriptive laboratory study. Methods: Ten unpaired cadavers were dissected. The attachments of the ALL were isolated. Its origin and insertion were marked with a 2 mm–diameter metallic sphere. Computed tomography scans were performed on the dissected parts under extension and 30°, 60°, and 90° of flexion; measurements of the distance between the 2 markers were taken at all mentioned degrees of flexion. The distances between the points were compared. Results: The mean ALL length increased with knee flexion. Its mean length at full extension and at 30°, 60°, and 90° of flexion was 37.9 ± 5.3, 39.3 ± 5.4, 40.9 ± 5.4, and 44.1 ± 6.4 mm, respectively. The mean increase in length from 0° to 30° was 3.99% ± 4.7%, from 30° to 60° was 4.20% ± 3.2%, and from 60° to 90° was 7.45% ± 4.8%. From full extension to 90° of flexion, the ligament length increased on average 16.7% ± 12.1%. From 60° to 90° of flexion, there was a significantly higher increase in the mean distance between the points compared with the flexion from 0° to 30° and from 30° to 60°. Conclusion: The ALL shows no isometric behavior during the range of motion of the knee. The ALL increases in length from full extension to 90° of flexion by 16.7%, on average. The increase in length was greater from 60° to 90° than from 0° to 30° and from 30° to 60°. The increase in length at higher degrees of flexion suggests greater tension with increasing flexion. Clinical Relevance: Knowledge of ALL behavior during the range of motion of the knee will allow for fixation (during its reconstruction) to be performed with a higher or lower tension, depending on the chosen degree of flexion.
Biological significance of HLA locus matching in unrelated donor bone marrow transplantation
Authors: Morishima Yasuo , Kashiwase Koichi , Matsuo Keitaro , Azuma Fumihiro , Morishima Satoko , Onizuka Makoto , Yabe Toshio , Murata Makoto , Doki Noriko , Eto Tetsuya , Mori Takehiko , Miyamura Koichi , Sao Hiroshi , Ichinohe Tatsuo , Saji Hiroo , Kato Shunichi , Atsuta Yoshiko , Kawa Keisei , Kodera Yoshihisa , Sasazuki Takehiko 
Published: December 2014

Key PointsSignificant HLA locus mismatches responsible for transplant-related events were determined in 7898 unrelated marrow donor transplants. This information provides a rationale for use of an algorithm for unrelated donor selection.
Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait
Authors: Jones Emma , Pasricha Sant-Rayn , Allen Angela , Evans Patricia , Fisher Chris A. , Wray Katherine , Premawardhena Anuja , Bandara Dyananda , Perera Ashok , Webster Craig , Sturges Pamela , Olivieri Nancy F. , St. Pierre Timothy , Armitage Andrew E. , Porter John B. , Weatherall David J. , Drakesmith Hal 
Published: December 2014

Key Points
Expanded erythropoiesis strongly drives hepcidin suppression in severe transfusion-dependent HbE β-thalassemia. β-thalassemia carriers, but not HbE carriers, have enhanced erythropoiesis associated with mildly suppressed hepcidin.
Early goal-directed therapy: what do we do now?
Authors: Levy Mitchell M 
Published: December 2014

AbstractThe meta-analysis of early goal-directed therapy (EGDT) by Gu and colleagues in the previous issue of Critical Care adds to the ongoing controversy about the value of EGDT for resuscitating patients with severe sepsis and septic shock. The results of the ProCESS (protocolized care for early septic shock) and ARISE (Australasian resuscitation in sepsis evaluation) trials failed to demonstrate any benefit of EGDT or protocolized resuscitation when compared with ‘usual care’. The questions are the following: What is ‘usual’ care? What is ‘real world’ care? Do the results of a robust and well-conducted randomized controlled trial - in which many patients may be excluded for a variety of reasons - reflect the care given to patients on a daily basis in our emergency departments and intensive care units? Of course, there are no obvious answers to these questions, and many clinicians look forward to managing these patients without protocols. For now, the data do seem to support the management of patients with septic shock without mandated central lines or protocols. Does this mean we should go back to the era of ‘do whatever you want’? No consensus exists among clinicians regarding optimal hemodynamic monitoring, and to date no method has been proven to be superior. Given the amount of fluids given prior to randomization in the ProCESS and ARISE trials, ‘usual care’ appears to now include aggressive, early fluid resuscitation with at least 20 mL/kg of crystalloid and rapid administration of appropriate antibiotics. Certainly, this reflects the impact of the original trial by Rivers and colleagues and the broad-based implementation of the Surviving Sepsis Campaign Guidelines and bundles. If this continues to define ‘usual care’, then perhaps it is no longer necessary to mandate specific protocols for resuscitation, as it appears that standard sepsis management has evolved to be consistent with published protocols.
Rotational thrombelastometry: a step forward to safer patient care?
Authors: Saner Fuat H 
Published: December 2014

AbstractThe study by Hincker and colleagues indicated that the perioperative use of rotational thrombelastometry (ROTEM™) could predict thromboembolic events in 90% of the cases in non-cardiac surgery. Viscoelastic tests (VETs) - ROTEM™ and thrombelastography (TEG™) - are used mainly to predict bleeding complications. Most conventional coagulation tests, like prothrombin time and activated partial thromboplastin time, can identify a disturbance in plasmatic hemostasis. However, the relevance of these assays is limited to the initiation phase of coagulation, whereas VETs are designed to assess the whole clotting kinetics and strength of the whole blood clot and reflect more the interaction between procoagulants, anticoagulants, and platelets. The first reports about VET and hypercoagulable state were published more than 25 years ago. Since then, several studies with different quality and sample size have been published, sometimes with conflicting results. A systematic review about hypercoagulable state and TEG™ indicated that further studies are needed to recommend VETs as a screening tool to predict postoperative thrombosis.
Fluid resuscitation should respect the endothelial glycocalyx layer
Authors: Guidet Bertrand , Ait-Oufella Hafid 
Published: December 2014

AbstractEndothelial glycocalyx degradation induced by fluid overload adds to the concern of a detrimental effect of uncontrolled fluid resuscitation and the risk of unnecessary fluid infusion. As a consequence, the use of new tools for monitoring response to fluids appears promising. From that perspective, the monitoring of plasma concentration of glycocalyx degradation markers could be useful.
Evaluation of urinary tissue inhibitor of metalloproteinase-2 in acute kidney injury: a prospective observational study
Authors: Yamashita Tetsushi , Doi Kent , Hamasaki Yoshifumi , Matsubara Takehiro , Ishii Takeshi , Yahagi Naoki , Nangaku Masaomi , Noiri Eisei 
Published: December 2014

Abstract
Introduction
Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an emerging acute kidney injury (AKI) biomarker. We evaluated the performance of urinary TIMP-2 in an adult mixed ICU by comparison with other biomarkers that reflect several different pathways of AKI.

Methods
In this study, we prospectively enrolled 98 adult critically ill patients who had been admitted to the adult mixed ICU. Urinary TIMP-2 and N-acetyl-β-d-glucosaminidase (NAG) and plasma neutrophil gelatinase-associated lipocalin (NGAL), interleukin-6 (IL-6) and erythropoietin (EPO) were measured on ICU admission. We evaluated these biomarkers’ capability of detecting AKI and its severity as determined by using the Kidney Disease Improving Global Outcomes serum creatinine criteria, as well as its capacity to predict in-hospital mortality. The impact of sepsis, the leading cause of AKI in ICUs, was also evaluated.

Results
We found AKI in 42 patients (42.9%). All biomarkers were significantly higher in AKI than in non-AKI. In total, 27 patients (27.6%) developed severe AKI. Urinary TIMP-2 was able to distinguish severe AKI from non-severe AKI with an area under the receiver operating characteristic curve (AUC-ROC) of 0.80 (95% confidence interval, 0.66 to 0.90). A total of 41 cases (41.8%) were complicated with sepsis. Although plasma NGAL and IL-6 were increased by sepsis, urinary TIMP-2 and NAG were increased not by sepsis, but by the presence of severe AKI. Plasma EPO was increased only by septic AKI. In-hospital mortality was 15.3% in this cohort. Urinary TIMP-2 and NAG, and plasma NGAL, were significantly higher in non-survivors than in survivors, although plasma IL-6 and EPO were not. Among the biomarkers, only urinary TIMP-2 was able to predict in-hospital mortality significantly better than serum creatinine.

Conclusion
Urinary TIMP-2 can detect severe AKI with performance equivalent to plasma NGAL and urinary NAG, with an AUC-ROC value higher than 0.80. Furthermore, urinary TIMP-2 was associated with mortality. Sepsis appeared to have only a limited impact on urinary TIMP-2, in contrast to plasma NGAL.
Variants of uncertain significance in BRCA: a harbinger of ethical and policy issues to come?
Authors: Cheon Jae Yeon , Mozersky Jessica , Cook-Deegan Robert 
Published: December 2014

AbstractAfter two decades of genetic testing and research, the BRCA1 and BRCA2 genes are two of the most well-characterized genes in the human genome. As a result, variants of uncertain significance (VUS; also called variants of unknown significance) are reported less frequently than for genes that have been less thoroughly studied. However, VUS continue to be uncovered, even for BRCA1/2. The increasing use of multi-gene panels and whole-genome and whole-exome sequencing will lead to higher rates of VUS detection because more genes are being tested, and most genomic loci have been far less intensively characterized than BRCA1/2. In this article, we draw attention to ethical and policy-related issues that will emerge. Experience garnered from BRCA1/2 testing is a useful introduction to the challenges of detecting VUS in other genetic testing contexts, while features unique to BRCA1/2 suggest key differences between the BRCA experience and the current challenges of multi-gene panels in clinical care. We propose lines of research and policy development, emphasizing the importance of pooling data into a centralized open-access database for the storage of gene variants to improve VUS interpretation. In addition, establishing ethical norms and regulated practices for sharing and curating data, analytical algorithms, interpretive frameworks and patient re-contact are important policy areas.
Partitioning of web applications for hybrid cloud deployment
Authors: Kaviani Nima , Wohlstadter Eric , Lea Rodger 
Published: December 2014

Abstract
Hybrid cloud deployment offers flexibility in trade-offs between the cost-savings/scalability of the public cloud and control over data resources provided at a private premise. However, this flexibility comes at the expense of complexity in distributing a system over these two locations. For multi-tier web applications, this challenge manifests itself primarily in the partitioning of application- and database-tiers. While there is existing research that focuses on either application-tier or data-tier partitioning, we show that optimized partitioning of web applications benefits from both tiers being considered simultaneously. We present our research on a new cross-tier partitioning approach to help developers make effective trade-offs between performance and cost in a hybrid cloud deployment. The general approach primarily benefits from two technical improvements to integer-programming based application partitioning. First, an asymmetric cost-model for optimizing data transfer in environments where ingress and egress data-transfer have differing costs, such as in many infrastructure as a service platforms. Second, a new encoding of database query plans as integer programs, to enable simultaneous optimization of code and data placement in a hybrid cloud environment. In two case studies the approach results in up to 54% reduction in monetary costs compared to a premise only deployment and 56% improvement in response time compared to a naive partitioning where the application-tier is deployed in the public cloud and the data-tier is on private infrastructure.
Classical solutions for the Cahn-Hilliard equation with decayed mobility
Authors: Huang Rui , Mei Ming , Yin Jingxue 
Published: December 2014

Abstract
We consider the Cahn-Hilliard equation with concentration dependent mobility in two dimensions. Global existence and uniqueness of classical solutions are established for a mobility with some delayed structure and general potential including

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