bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eine makrozyklische Hybrid‐PET/MRT‐Sonde für die quantitative Perfusionsbildgebung in vivo
Authors: Kretschmer Jan , Chiaffarelli Remy , Vuozzo Marta , Cotton Jonathan , Blahut Jan , Ráliš Jan , Dračínský Martin , Matějková Stanislava , Seeling Ulrike , Schmid Andreas M. , Martins André F. , Polasek Miloslav 
Published: July 2024

AbstractDie Perfusionsdynamik spielt eine entscheidende Rolle bei der Versorgung des Gewebes mit lebenswichtigen Nährstoffen und Sauerstoff und der Abführung von Stoffwechselendprodukten. Bildgebende Verfahren wie die Magnetresonanztomographie (MRT), die Computertomographie (CT) und die Positronen‐Emissions‐Tomographie (PET) verwenden Kontrastmittel, um Perfusions‐ und Ausscheidungsmuster sichtbar zu machen. Hybrid‐PET/MRT kombiniert die quantitativen Möglichkeiten und Empfindlichkeit der PET mit der hohen funktionellen und anatomischen Detailgenauigkeit der MRT und verspricht eine hohe Präzision bei der molekularen Bildgebung. Die Entwicklung von dualen PET/MRT‐Sonden wurde jedoch durch die anspruchsvolle Synthese und Markierung mit radioaktiven Isotopen erschwert. Hier stellen wir eine neuartige PET/MRT‐Sonde, [18F][Gd(FL1)], vor, die eine hervorragende Stabilität aufweist, die mit der von makrozyklischen MRT‐Kontrastmitteln vergleichbar ist, welche in der klinischen Praxis eingesetzt werden. Das einzigartige molekulare Design von [18F][Gd(FL1)] ermöglicht eine selektive und schnelle Markierung des Gadoliniumchelats im letzten Syntheseschritt. Durch die Nutzung der Stärken von MRT‐ und PET‐Signalen ermöglicht die Sonde eine quantitative in vivo‐Darstellung der Perfusions‐ und Ausscheidungsdynamik durch eine innovative voxelbasierte Analyse. Die diagnostischen Fähigkeiten von [18F][Gd(FL1)] wurden in einer Pilotstudie an gesunden Mäusen nachgewiesen, in der erfolgreich frühe Fälle von einseitiger Nierenfunktionsstörung, einer Erkrankung, die in der Regel schwer zu diagnostizieren ist, nachgewiesen wurden. Diese Studie stellt einen neuen Ansatz für PET/MRT vor und betont ein optimiertes Sondendesign für eine praktische Synthese und eine verbesserte diagnostische Genauigkeit.
Standardized Parts for Activation of Small GTPase Signaling in Living Cells
Authors: He Yuchen , Faulkner Benjamin M. , Roberti Meaghan A. , Bassford Dana K. , Stains. Cliff I. 
Published: July 2024

AbstractSmall GTPases comprise a superfamily of over 167 proteins in the human genome and are critical regulators of a variety of pathways including cell migration and proliferation. Despite the importance of these proteins in cell signaling, a standardized approach for controlling small GTPase activation within living cells is lacking. Herein, we report a split‐protein‐based approach to directly activate small GTPase signaling in living cells. Importantly, our fragmentation site can be applied across the small GTPase superfamily. We highlight the utility of these standardized parts by demonstrating the ability to directly modulate the activity of four different small GTPases with user‐defined inputs, providing the first plug and play system for direct activation of small GTPases in living cells.
Light‐Induced Electron Transfer in a [NiFe] Hydrogenase Opens a Photochemical Shortcut for Catalytic Dihydrogen Cleavage
Authors: Karafoulidi‐Retsou Chara , Lorent Christian , Katz Sagie , Rippers Yvonne , Matsuura Hiroaki , Higuchi Yoshiki , Zebger Ingo , Horch Marius 
Published: July 2024

Abstract[NiFe] hydrogenases catalyze the reversible cleavage of molecular hydrogen into protons and electrons. Here, we have studied the impact of temperature and illumination on an oxygen‐tolerant and thermostable [NiFe] hydrogenase by IR and EPR spectroscopy. Equilibrium mixtures of two catalytic [NiFe] states, Nia‐C and Nia‐SR’’, were found to drastically change with temperature, indicating a thermal exchange of electrons between the [NiFe] active site and iron‐sulfur clusters of the enzyme. In addition, IR and EPR experiments performed under illumination revealed an unusual photochemical response of the enzyme. Nia‐SR’’, a fully reduced hydride intermediate of the catalytic cycle, was found to be reversibly photoconverted into another catalytic state, Nia‐L. In contrast to the well‐known photolysis of the more oxidized hydride intermediate Nia‐C, photoconversion of Nia‐SR’’ into Nia‐L is an active‐site redox reaction that involves light‐driven electron transfer towards the enzyme's iron‐sulfur clusters. Omitting the ground‐state intermediate Nia‐C, this direct interconversion of these two states represents a potential photochemical shortcut of the catalytic cycle that integrates multiple redox sites of the enzyme. In total, our findings reveal the non‐local redistribution of electrons via thermal and photochemical reaction channels and the potential of accelerating or controlling [NiFe] hydrogenases by light.
Half‐sandwich iridium complexes: Synthesis and catalytic activity in dehydrogenation of alcohols to carboxylic acids
Authors: Ye Lin‐Wu , Yao Zi‐Jian 
Published: July 2024

A series of N,N‐chelate half‐sandwich iridium complexes were synthesized by a simple method with good yields. The dehydrogenation of a series of aromatic and aliphatic primary alcohols to corresponding carboxylic acids has been successfully achieved by the prepared air stable iridium complexes under mild reaction conditions. Carboxylic acids were obtained in high yields under open flask condition with broad substrates and good tolerance to sensitive functional groups. Such a half‐sandwich iridium catalyst system showed desirable stability and catalytic activity, and the achievement of a high TOF of 372.0 h−1 could be observed with an extremely low catalyst loading of only 0.05 mol%. Furthermore, the sustainable catalyst could be reused for a minimum of five cycles without obviously losing its activity, highlighting its potential application in industry. Structure of N,N‐chelate iridium complexes 1 and 3 were determined by single‐crystal X‐ray analysis.
Construction of ternary heterostructure of zeolite/Fe3O4/CuS/CuWO4 as a reusable: Characterization studies
Authors: Ali Alyaa Hussein , Alwared Abeer I. 
Published: July 2024

AbstractThe presence of pharmaceutical pollutants in the environment has become a growing concern due to their persistence and toxic nature. In response to this issue, semiconductor photocatalyst materials have emerged as promising candidates for environmental pollutant removal, particularly under solar light irradiation. In this study, we developed a novel zeolite/Fe3O4/CuS/CuWO4 heterojunction nanocomposite through a simple and facile method. The fabrication process involved a multistep approach wherein Fe3O4, CuS, and CuWO4 were incorporated onto the surface of pure zeolite nanoparticles. X‐ray diffraction, scanning electron microscope, transmission electron microscope, ultraviolet–visible diffuse reflectance spectroscopy, Fourier transform infrared, photoluminescence, and vibrating sample magnetometry were analyzed. The results demonstrated that the zeolite/Fe3O4/CuS/CuWO4 heterojunction nanocomposite exhibited a synergistic integration of excellent properties, indicative of the successful construction of a heterostructure within the nanocomposite. Furthermore, the photocatalytic efficiency of the nanocomposite was evaluated for the degradation of the pharmaceutical pollutant fluoroquinolone levofloxacin (LEVO), and it outperformed individual photocatalysts. Notably, the zeolite/Fe3O4/CuS/CuWO4 nanocomposite achieved an impressive degradation rate of approximately 82.67% of LEVO after 120 min of exposure. Importantly, the synthesized nanocomposite demonstrated excellent reusability, with a photodegradation efficiency of 60.45% after the fifth cycle of LEVO degradation, as there was no significant loss in photocatalytic activity over repeated cycles. Furthermore the highest total organic carbon removal efficiency estimated is 57.43% for heterojunction nanocomposite. These findings highlight the potential of the zeolite/Fe3O4/CuS/CuWO4 heterojunction nanocomposite as an effective, eco‐friendly photocatalyst for pharmaceutical pollutant removal from the environment.
Synthesis of new phenothiazine derivatives: Molecular docking, assessment of cytotoxic activity and oxidant–antioxidant properties on PCS‐201‐012, HT‐29, and SH‐SY5Y cell lines
Authors: Tan Bensu , Kartal Yasemin , Yesilyurt Fatma , Akdoğan Nurdan , Doyduk Doğukan , Dişli Ali 
Published: July 2024

AbstractPhenothiazine (PTZ) derivatives have been acknowledged as versatile compounds with significant implications across various areas of medicine, particularly, in cancer research. The cytotoxic effects of synthesized compounds on both normal and cancerous cells, along with their oxidant–antioxidant properties, are pivotal factors in cancer treatment strategies. In the current study, eight new PTZ derivatives were synthesized and the compounds' cytotoxic activities were assessed by 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5 diphenyl tetrazolium bromide (MTT) assay while the oxidant–antioxidant properties were evaluated by oxidative stress index (OSI) calculation in SH‐SY5Y (a human neuroblastoma cell line), HT‐29 (a human colorectal adenocarcinoma cell line), and PCS‐201‐012 (a human primary dermal fibroblast cell line) cells. Consequently, the half‐maximal inhibitory concentration (IC50) values of compound 3a were determined to be 218.72, 202.85, and 227.86 μM while the IC50 values of compound 3b were defined to be 227.42, 199.27, and 250.11 μM in PCS‐201‐012, HT‐29, and SH‐SY5Y cells, respectively. Additionally, it was determined that the synthesized compounds demonstrated the lowest OSI in PCS‐201‐012 cells as compared to the other cell lines.
TiO2 for efficient photocatalytic decomposition of acetaldehyde: An investigation of the effects of annealing temperature, humidity, and binder
Authors: Kwon Yong‐Sog , Jung Kyu‐Chul , Zhao Shufang , Ji Yujing , Saqlain Shahid , Kim Young Dok 
Published: July 2024

AbstractTiO2 photocatalysts were synthesized by simple sol gel method and annealed at 300, 500, and 600°C. Photocatalytic performance of as‐prepared TiO2 and annealed TiO2 samples was evaluated for the decomposition of acetaldehyde under UV light irradiation. TiO2 annealed at 500°C (T500) showed the highest acetaldehyde removal performance, which was attributed to combined effects of its crystallinity, defect density, surface area, narrow band gap with the dual phase of TiO2, and lifetimes of charge carriers. In humid conditions, overall acetaldehyde removal performance of T500 slightly decreased, but the extent of total oxidation of acetaldehyde into CO2 increased in high humidity as compared to dry conditions. Moreover, fixation of T500 on mica sheet using binders resulted in promising photocatalytic performance, making it a potential candidate for air purification applications. Fourier‐transform infra‐red (FT‐IR) analysis confirmed the stable existence of binder structure under dry air and UV treatment, which is crucial for real applications.
Gamification strategy to promote social and human factors in the training of software engineers: A case study
Authors: Gasca‐Hurtado Gloria Piedad , Machuca‐Villegas Liliana 
Published: July 2024

AbstractSoftware Engineering is a discipline frequently reflected in training strategies. This discipline requires certain levels of abstraction to achieve the competencies and skills necessary for the professional development of future software developers. The software industry increasingly demands that professionals in this discipline have social and human skills to achieve highly productive teams. Therefore, these teams should respond to such demands in a world with increasing dependence on technology and the development of software products. Traditional pedagogical strategies often need help adapting to the new generations of software engineers and responding in a limited way to the demands of teaching processes related to this discipline. This article evaluates a gamification‐based strategy designed for the Software Engineering course at a Latin American higher education institution. This course addressed software project management as a training objective. Such a strategy was designed with a gamification‐based model to influence the productivity of software development teams. The results of using the model show its efficiency and usefulness as a guide for implementing new strategies based on gamification that considers social and human factors (SHFs) to intervene in the productivity of software development teams. The challenges designed in the proposal presented managed to promote SHFs in the participants, according to the analysis of the prepared case study. According to these results, the factors considered relate to skills and experience in managing software development projects, motivation, and communication. The activities executed by the participants in the context of the case study strengthened the human side of the team and allowed its growth to achieve its objectives.
Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Ruellia tuberosa L.: A Review
Authors: Sharma Akanksha , Kumar Adarsh , Singh Ankit Kumar , Kumar K. Jayaram , Narasimhan Balasubramanian , Kumar Pradeep 
Published: July 2024

AbstractNatural Products continue to be the purest source of physiologically active molecules employed in the identification of possible lead compounds in the drug discovery process. Acanthaceae is a big plant family with around 2500 species, found primarily in subtropical and tropical regions, as well as the Mediterranean, Australia, and the United States. Several species of the Acanthaceae family have been used traditionally to treat a variety of diseases, including gastrointestinal and cardiovascular ailments, etc. Ruellia tuberosa commonly known as “Mexican Bluebell” is a perennial herb that originated in Central America and has spread to some countries in the Southern tropics and Southeast Asia. It has been utilized as a traditional Rasayana plant from ancient times. R. tuberosa extracts and phytochemicals showed potent bioactivities, such as anticancer, anti‐inflammatory, wound healing, antifungal, antimicrobial, anti‐diabetic, hypoglycemic, hypolipidemic, gastro‐protective, and anthelminthic activities. Chemical analyses have unveiled a range of bioactive constituents within the plant, including alkaloids, flavonoids, saponins, and phenolic compounds, suggestive of its therapeutic potential. Collectively, this review provides an overview of R. tuberosa, encompassing its traditional uses, ethnomedicinal importance, phytochemistry, pharmacological properties, and toxicity.
A hazardous collateral pathway following asymptomatic lead‐related venous occlusion?
Authors: Zagkli Fani , Chiladakis John 
Published: July 2024

Key Clinical MessageRoutine venography should be performed before the device upgrade. Clinicians should not be unconcerned because of the lack of symptoms following lead‐related venous occlusion. Knowledge of collateral anatomy is essential for future interventional plans. The venous pathway's return to the right atrium may entail risks to patient outcomes.
Extraction of an ectopic supernumerary tooth through nasal cavity with piezosurgery under local anesthesia: A case report
Authors: Ainiwaer Ailimaierdan , Yiminjiang Bumairemu , Ling Wang 
Published: July 2024

Key Clinical MessageThe ectopic supernumerary teeth (ST) commonly occur in the oral cavity. Ectopic ST in the maxilla can be extracted not only through an intraoral approach but also through a nasal approach.AbstractThe ectopic supernumerary teeth (ST) commonly occur in the oral cavity. We are reporting a case of a 23‐year‐old female patient with one ectopic ST in the anterior midmaxillary region. We extracted the ectopic ST under local tissue anesthesia through the nasal cavity using piezosurgery and minimally invasive extraction tools. During the operation, the adjacent structures remained intact, and the patient discomfort. This case indicates that ectopic ST in the maxilla can be extracted not only through an intraoral approach but also through a nasal approach.
Enhanced Electrochemical Performance of NiMn Layered Double Hydroxides/Graphene Oxide Composites Synthesized by One‐Step Hydrothermal Method for Supercapacitors
Authors: Chen Jun , Jing Xin , Wang Ji‐Chao , Zhang Wan‐Qing , Zhang Yong 
Published: July 2024

AbstractThis study aims to enhance the performance of supercapacitors, focusing particularly on optimizing electrode materials. While pure NiMn layered double hydroxides (LDHs) exhibit excellent electrochemical properties, they have limitations in achieving high specific capacitance. Therefore, this paper successfully synthesized composite materials of NiMn LDHs with varying loadings of graphene oxide (GO) using a hydrothermal method. Systematic physicochemical characterization of the synthesized materials, such as powder X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), field‐emission scanning electron microscopy (FE‐SEM), and Raman spectroscopy, revealed the influence of GO doping on the microstructure and electrochemical performance of NiMn LDHs. Electrochemical tests demonstrated that the NiMn LDHs/GO electrode material exhibited optimal electrochemical performance with a specific capacitance of 2096 F g−1 at 1 A g−1 current density and 1471 F g−1 at 10 A g−1, when GO doping level was 0.45 wt %. Furthermore, after 1000 cycles of stability testing, the material retained 53.3 % capacitance at 5 A g−1, indicating good cyclic stability. This study not only provides new directions for research on supercapacitor electrode materials but also offers new strategies for developing low‐cost and efficient electrode materials.
Can Chirality Answer Whether We Are Alone?
Authors: Bagdžiūnas Gintautas 
Published: July 2024

ABSTRACTDetecting biosignatures of life in extraterrestrial environments remains one of the primary objectives of scientific inquiry. Currently, both remote and direct detection methods are primarily aimed at identifying key molecular classes fundamental to terrestrial biology. However, a more universally applicable spectroscopic approach could involve searching for homochiral molecules. Thus, this perspective delves into the significance of homochirality as a critical factor in the origin of life. Without homochirality, the formation of self‐recognizing and self‐replicating complex molecules would be hindered. The various hypotheses concerning the origin of homochiral molecules have been explored and analyzed within this context. This perspective emphasizes the potential for discovering extraterrestrial microscopic life through the detection of homochiral molecules using chirodetecting methods such as chromatography and chiroptical spectroscopy or circular polarimetry as a promising remote technique. This discussion highlights the importance of homochirality in the broader search for life beyond Earth and underscores the need for innovative methodologies and instrumentation in astrobiological research. These techniques can be an effective method for detecting homochirality on future planetary missions.
Preparation and performance analysis of nano‐crosslinking agent for sulphonated guar gum fracturing fluid
Authors: Zhou Chengyu , Chen Yating , Xiao Ying , Wu Yani , Yang Chunming , Yu Mengjie , Liu Lin 
Published: July 2024

AbstractIn order to solve the problems of poor temperature resistance and low crosslinking efficiency of crosslinking agent for sulphonated guar gum fracturing fluid, in this paper, nano‐silica was reacted with 3‐aminopropyltriethoxysilane to obtain surface‐modified nano‐silica, which was then reacted with boric acid and n‐butyl titanate to obtain nano‐silica‐based boron‐titanium composite crosslinking agent. Its physical properties and structure were characterized by infrared (IR), laser particle size analysis, X‐ray diffraction (XRD), and atomic force microscopy (AFM). The sulphonated hydroxypropyl guar gum fracturing fluids formed by nano‐crosslinking agent were analyzed: When the temperature was uniformly increased from 25 to 120°C and the shear rate was 170 s−1, the viscosity was finally constant at about 50 mPa · s, which indicated that the temperature and shear resistance were good; the system had a better filtration‐loss reduction performance; the average sedimentation rate of ceramic grains in the fracturing fluid system was 0.00872 cm · min−1, indicating that the system had good sand carrying performance; the damage rate of fracturing fluid filtrate to the core was 23.33%; the gel breaking performance test showed that the fracturing fluid had good gel breaking performance. By analyzing the performance of the fracturing fluid, it can be seen that the nano‐crosslinking agent has the advantages of good temperature resistance and high cross‐linking efficiency compared with the traditional boron and titanium cross‐linking agents.
FeNi‐LDH Coated With Orange‐Peel Carbon Aerogel for Oxygen Evolution Reaction
Authors: Teng Yang , Ji Peng‐Cheng , Jia Hai‐Lang 
Published: July 2024

AbstractIn this work, the waste orange‐peel was used as carbon source, and the orange‐peel derived carbon material can be obtained through simple pyrolysis. Then, we designed the structure of orange‐peel carbon aerogel grown on iron‐nickel layered double hydroxides in situ to achieve the effect of carbon coating (FeNi‐LDH/CA). The oxygen evolution reaction catalytic performance of FeNi‐LDH/CA is excellent, far exceeding that of commercial RuO2. In 1 M KOH, the overpotential of FeNi‐LDH/CA is only 250 mV (10 mA cm−2), obviously better than that of commercial RuO2 (295 mV). FeNi‐LDH/CA shows good cycling stability, and after long‐term i‐t testing, the performance only decays by 3 % after running at 100 mA cm−2 for 100 h. When used as an anode, the voltage of water‐splitting is only 1.48 V at 10 mA cm−2. The rechargeable liquid zinc‐air battery based on Pt/C‐FeNi‐LDH/CA catalyst has higher open‐circuit voltage (1.543 V) and galvanostatic discharge capacity at 1.23 V (830 min, 10 mA cm−2). Moreover, the zinc‐air battery based on Pt/C‐FeNi‐LDH/CA has a small charge‐discharge voltage gap (0.65 V) at 10 mA cm−2, after 200 consecutive cycles (66 h), the charge‐discharge voltage gap only increased by about 30 mV, indicating good cycling stability.