bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural network auto‐segmentation of serial‐block‐face scanning electron microscopy images exhibit collagen fibril structural differences with tendon type and health
Authors: Bloom Ellen T. , Sabanayagam Chandran R. , Benson Jamie M. , Lin Lily M. , Ross Jean L. , Caplan Jeffrey L. , Elliott Dawn M. 
Published: August 2024

AbstractA U‐Net machine learning algorithm was adapted to automatically segment tendon collagen fibril cross‐sections from serial block face scanning electron microscopy (SBF‐SEM) and create three‐dimensional (3D) renderings. We compared the performance of routine Otsu thresholding and U‐Net for a positional tendon that has low fibril density (rat tail tendon), an energy‐storing tendon that has high fibril density (rat plantaris tendon), and a high fibril density tendon hypothesized to have disorganized 3D ultrastructure (degenerated rat plantaris tendon). The area segmentation of the tail and healthy plantaris tendon had excellent accuracy for both the Otsu and U‐Net, with an Intersection over Union (IoU) of 0.8. With degeneration, only the U‐Net could accurately segment the area, whereas Otsu IoU was only 0.45. For boundary validation, the U‐Net outperformed Otsu segmentation for all tendons. The fibril diameter from U‐Net was within 10% of the manual segmentation, however, the Otsu underestimated the fibril diameter by 39% in healthy plantaris and by 84% in the degenerated plantaris. Fibril geometry was averaged across the entire image stack and compared across tendon types. The tail had a lower fibril area fraction (58%) and larger fibril diameter (0.31 µm) than the healthy plantaris (67% and 0.21 µm) and degenerated plantaris tendon (66% and 0.19 µm). This method can be applied to a large variety of tissues to quantify 3D collagen fibril structure.
Exploring the effects of whey protein components on the interaction and stability of cyanidin‐3‐O‐glucoside
Authors: Zhang Huimin , Ju Mengmeng , Hamid Nazimah , Ma Qianli , Shang Dansen , Jia Chengli , Xiao Yuhang , Jiang Shijing , Qiu Haoqin , Luan Wenli , Sun Aidong 
Published: August 2024

AbstractBACKGROUNDAnthocyanins are susceptible to degradation due to external factors. Despite the potential for improved anthocyanin stability with whey protein isolate (WPI), the specific effects of individual components within WPI on the stability of anthocyanins have yet to be studied extensively. This study investigated the interaction of WPI, β‐lactoglobulin (β‐Lg), bovine serum albumin (BSA), and lactoferrin (LF) with cyanidin‐3‐O‐glucoside (C3G), and also considered their effects on stability.RESULTSFluorescence analysis revealed static quenching effects between C3G and WPI, β‐Lg, BSA, and LF. The binding constants were 1.923 × 103 L · mol⁻¹ for WPI, 24.55 × 103 L · mol⁻¹ for β‐Lg, 57.25 × 103 L · mol⁻¹ for BSA, and 1.280 × 103 L · mol⁻¹ for LF. Hydrogen bonds, van der Waals forces, and electrostatic attraction were the predominant forces in the interactions between C3G and WPI and between C3G and BSA. Hydrophobic interaction was the main binding force in the interaction between C3G and β‐Lg and between C3G and LF. The binding of C3G with WPI, β‐Lg, BSA, and LF was driven by different thermodynamic parameters. Enthalpy changes (∆H) were −38.76 kJ · mol⁻¹ for WPI, −17.59 kJ · mol⁻¹ for β‐Lg, −16.09 kJ · mol⁻¹ for BSA, and 39.50 kJ · mol⁻¹ for LF. Entropy changes (∆S) were −67.21 J · mol⁻¹·K⁻¹ for WPI, 3.72 J · mol⁻¹·K⁻¹ for β‐Lg, 37.09 J · mol⁻¹·K⁻¹ for BSA, and 192.04 J · mol⁻¹·K⁻¹ for LF. The addition of C3G influenced the secondary structure of the proteins. The decrease in the α‐helix content suggested a disruption and loosening of the hydrogen bond network structure. The presence of proteins enhanced the light stability and thermal stability (stability in the presence of light and heat) of C3G. In vitro simulated digestion experiments demonstrated that the addition of proteins led to a delayed degradation of C3G and to improved antioxidant capacity.CONCLUSIONThe presence of WPI and its components enhanced the thermal stability, light stability, and oxidation stability of C3G. Preheated proteins exhibited a more pronounced effect than unheated proteins. These findings highlight the potential of preheating protein at appropriate temperatures to preserve C3G stability and bioactivity during food processing. © 2024 Society of Chemical Industry.
Eutrophication and urbanization enhance methane emissions from coastal lagoons
Authors: Bonaglia Stefano , Cheung Henry L. S. , Politi Tobia , Vybernaite‐Lubiene Irma , McKenzie Tristan , Santos Isaac R. , Zilius Mindaugas 
Published: August 2024

AbstractCoastal lagoons are important nutrient filters and carbon sinks but may release large amounts of methane (CH4) to the atmosphere. Here, we hypothesize that eutrophication and population density will turn coastal lagoons into stronger methane emitters. We report benthic fluxes from 187 sediment cores incubated from three of the largest European lagoons suffering persistent eutrophication. Methane fluxes were mainly driven by sediment porosity, organic matter, and dissolved inorganic carbon (DIC) fluxes. Methane was always supersaturated (250–49,000%) in lagoon waters leading to large, variable emissions of 0.04–26 mg CH4 m−2 d−1. Combining our new dataset with earlier estimates revealed a global coastal lagoon emission of 7.9 (1.4–34.7) Tg CH4 yr−1 with median values of 5.4 mg CH4 m−2 d−1. Lagoons with very highly populated catchments released much more methane (223 mg CH4 m−2 d−1). Overall, projected increases in eutrophication, organic loading and population densities will enhance methane fluxes from lagoons worldwide.
Consumer decision‐making in cosmetic surgery: An interdisciplinary review identifying key challenges and implications for marketing theory
Authors: Krywuczky Fabienne , Kleijnen Mirella 
Published: August 2024

AbstractConsumer interest in cosmetic surgery has grown tremendously in recent years. However, despite the long‐lasting implications of cosmetic surgery decisions on consumer well‐being, existing insights on these decisions remain limited and scattered across various fields. Through an interdisciplinary bibliometric review, we identify that previous research has primarily focused on five aspects shaping consumers' decisions in cosmetic surgery: (1) differing perspectives, (2) social drivers, (3) individual drivers, (4) online media content, and (5) influences relevant to labiaplasty. These investigations stem from the fields of psychology, sociology, communication, and healthcare and aim to understand especially consumer intentions to undergo surgery at the pre‐consumption stage. In this research, we delineate how marketing researchers can advance insights along the entire consumer surgery journey (i.e., pre‐consumption, consumption, and post‐consumption stage) through a better understanding of (i) the phenomenon and its different treatments, (ii) the role of identity, (iii) stakeholder interactions, and (iv) how social media and technology shape cosmetic surgery decisions. Finally, we highlight how studying these topics can contribute to marketing theory through novel insights on the self and identity, the body's meaning in consumption, and self‐enhancement practices.
Revealing the double‐edged sword: Introducing the Technology and Consumer Well‐being Paradox Model
Authors: McLean Graeme , Krey Nina , Barhorst Jennifer Brannon 
Published: August 2024

AbstractWhile discourse on technology and consumer well‐being has been at the forefront of academics' and practitioners' agendas, the theoretical understanding of the complex interplay between technology and consumer well‐being has remained tenuous. To address this gap in our understanding of technology's influence on consumer well‐being, this research provides a comprehensive literature review of recent articles published in Psychology & Marketing. Findings indicate a double‐edged sword where technology has the propensity to not only foster a state of negative well‐being but can also enhance consumers' well‐being. Additionally, a technology well‐being paradox is uncovered whereby technology is used to manage the negative effects of technology use. Accordingly, we introduce the Technology and Consumer Well‐being Paradox Model that incorporates technology's propensity to enhance, diminish, and manage eudaimonic and hedonic consumer well‐being. Furthermore, the influence of the purpose of technology use and changes to consumer well‐being over time with technology use are also considered. Finally, we provide pertinent avenues for future research to further understanding on the technology and consumer well‐being paradox.
Handmaking a better future: A scoping review on the role of handmade activities in advancing individual and societal well‐being
Authors: Birau Mia M. 
Published: August 2024

AbstractBuilding something with your hands, whether a piece of furniture, a scarf, or a vase, triggers a unique mental process enhancing a feeling of well‐being. Various research studies explore the potential effects of diverse types of activities involving hand labor. This scoping review analyzes 181 such studies spanning multiple disciplines (psychology, marketing, technology, design, health), and explores the richness of these activities and their distinct effects on individual and societal well‐being. Through this comprehensive analysis, the review enhances the understanding of the effects of handmade activities on consumer well‐being and advances marketing knowledge within the broader context of well‐being. Additionally, it probes into the commonalities among different academic theories, identifying gaps in existing marketing and psychology research and proposing paths for future exploration.
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer
Authors: Bai Yi‐Ru , Yang Wei‐Guang , Jia Rui , Sun Ju‐Shan , Shen Dan‐Dan , Liu Hong‐Min , Yuan Shuo 
Published: August 2024

AbstractChemotherapies are commonly used in cancer therapy, their applications are limited to low specificity, severe adverse reactions, and long‐term medication‐induced drug resistance. Poly(ADP‐ribose) polymerase (PARP) inhibitors are a novel class of antitumor drugs developed to solve these intractable problems based on the mechanism of DNA damage repair, which have been widely applied in the treatment of ovarian cancer, breast cancer, and other cancers through inducing synthetic lethal effect and trapping PARP‐DNA complex in BRCA gene mutated cancer cells. In recent years, PARP inhibitors have been widely used in combination with various first‐line chemotherapy drugs, targeted drugs and immune checkpoint inhibitors to expand the scope of clinical application. However, the intricate mechanisms underlying the drug resistance to PARP inhibitors, including the restoration of homologous recombination, stabilization of DNA replication forks, overexpression of drug efflux protein, and epigenetic modifications pose great challenges and desirability in the development of novel PARP inhibitors. In this review, we will focus on the mechanism, structure–activity relationship, and multidrug resistance associated with the representative PARP inhibitors. Furthermore, we aim to provide insights into the development prospects and emerging trends to offer guidance for the clinical application and inspiration for the development of novel PARP inhibitors and degraders.
Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety
Authors: Wang Jinyi , Zhou Tingting 
Published: August 2024

AbstractDrug safety is a paramount concern in the field of drug development, with researchers increasingly focusing on the bidirectional regulation of gut microbiota in this context. The gut microbiota plays a crucial role in maintaining drug safety. It can influence drug transport processes in the body through various mechanisms, thereby modulating their efficacy and toxicity. The main mechanisms include: (1) The gut microbiota directly interacts with drugs, altering their chemical structure to reduce toxicity and enhance efficacy, thereby impacting drug transport mechanisms, drugs can also change the structure and abundance of gut bacteria; (2) bidirectional regulation of intestinal barrier permeability by gut microbiota, promoting the absorption of nontoxic drugs and inhibiting the absorption of toxic components; (3) bidirectional regulation of the expression and activity of transport proteins by gut microbiota, selectively promoting the absorption of effective components or inhibiting the absorption of toxic components. This bidirectional regulatory role enables the gut microbiota to play a key role in maintaining drug balance in the body and reducing adverse reactions. Understanding these regulatory mechanisms sheds light on novel approaches to minimize toxic side effects, enhance drug efficacy, and ultimately improve drug safety. This review systematically examines the bidirectional regulation of gut microbiota in drug transportation from the aforementioned aspects, emphasizing their significance in ensuring drug safety. Furthermore, it offers a prospective outlook from the standpoint of enhancing therapeutic efficacy and reducing drug toxicity, underscoring the importance of further exploration in this research domain. It aims to provide more effective strategies for drug development and treatment.
How Do We Better Serve Excluded Populations When Delivering Digital Health Technology? Inclusion Evaluation of a Digital Musculoskeletal Self‐Management Solution
Authors: Wanless Ben , Hassan Nawal , McClellan Carey , Sothinathan Christina , Abelleyra Lastoria Diego Agustín , Herweijer Thomas , Thorpe Jayne , Noblet Tim , Berry Alice 
Published: August 2024

ABSTRACTBackgroundDigital self‐management platforms have been proposed as a solution to better support people manage their musculoskeletal (MSK) condition. However, research studies often explicitly exclude people who can't access internet connected devices. An important consideration is that digital exclusion (for people without access to an internet connected device) from these new digital options will worsen already existing inequality and inequity in healthcare.AimTo evaluate the acceptability and potential causes of digital exclusion of the South West London (SWL) MSK self‐management app.Objectives(1) Explore why some patients are not using the app and any barriers they have. Explore why some clinicians are not prescribing the app. (2) Make recommendations, based on these findings, to improve digital inclusion.Methods/DesignAn explanatory sequential mixed method service evaluation that consisted of initial questionnaires to identify suitable collaborators, followed by structured interviews of patients and clinicians.ResultsFollowing a comprehensive data analysis, 10 sub‐themes were grouped into four main themes: (1) Beliefs: Importance of understanding the role of digital; face to face consultation is still valued and needed. (2) Barriers: Lack of digital literacy; lack of physical examination/contact with a clinician. (3) Enablers: Immediate access to advice and information; perceived better control over health; ease of use; no appointment needed. (4) Solutions: Support and training; greater awareness.ConclusionsAs digital health technology develops, strategies must change, requiring deliberate work and investments to improve inclusion. Our findings highlight how digital technology design and delivery can be adapted to address the causes of digital exclusion.
Effect of Core Exercises on Clinical and Functional Outcomes After Total Knee Arthroplasty in Individuals With Knee Osteoarthritis: A Systematic Review
Authors: Shetty Saidan , Maiya G. Arun , KG Mohandas Rao , Vijayan Sandeep , George Bincy M. 
Published: August 2024

ABSTRACTBackgroundCore muscles constitute the centre of the kinetic chain, and core exercises have been effective in improving outcomes in many postsurgical lower extremity musculoskeletal conditions. However, the literature on the implementation of core exercises after TKA has not been summarised.ObjectiveThe objective was to review the evidence on the effect of core exercises on clinical and functional outcomes after TKA in individuals with knee osteoarthritis (OA).MethodsPubMed, Scopus, CINAHL, Web of Science, the Cochrane Library, and ProQuest databases were explored with appropriate keywords for studies published on the effect of core exercises on TKA from inception to 1 April 2024. Two authors independently screened the titles and abstracts and full‐texts, and a third author solved the discrepancies. Risk of bias assessment was done with the Joanna Briggs Critical Appraisal tool. The final articles were systematically summarised.ResultsA total of 1485 records were retrieved. Sixty‐four articles were included for screening full‐texts, and four articles were ultimately included. Core exercises were administered for three to 6 weeks. The administration of core exercises along with the standard knee rehabilitation programme significantly improved balance, mobility, knee function, transverse abdominis muscle thickness, transversus abdominis contraction, and quality of life after TKA (p < 0.05).ConclusionsCore exercises can be administered as an adjunct to standard rehabilitation programs to improve clinical and functional outcomes after TKA. However, there is a dearth of literature in this domain, and more studies are warranted.Trial RegistrationPROSPERO Registration Number: CRD42024542992
Mechanical study on hybrid joining type carbon fiber reinforced composite
Authors: Kaplan Nil , Gulluoglu Arif Nihat , Turkmen Halit Suleyman 
Published: August 2024

AbstractThis paper presents a comprehensive study of the fabrication and joining mechanisms of carbon fiber reinforced polymer (CFRP) composites. The CFRP composites were fabricated by hand lay‐up and vacuum bagging methods. In order to improve the efficiency of the CFRP‐CFRP and CFRP‐AL 7075‐T651 joints, laminates with varying overlap lengths of 25 and 60 mm single lap joints were prepared in both multi‐riveted and hybrid bonded/riveted joint configurations. Due to the epoxy compatibility of CFRP‐CFRP joints, riveted/bonded hybrid joints (HJs) showed superior improvements compared to riveted joints for both material combinations at 25 and 60 mm overlap lengths. Non‐epoxy compatible surfaces of CFRP‐AL 7075‐T651 specimens performed similarly to riveted joints in hybrid configurations. The use of epoxy compatible surfaces was found to increase the joint strength in CFRP‐CFRP single lap hybrid joints in proportion to the increase in overlap length. Ansys non‐linear analysis and experimental results were complementary. The new improvements in joint efficiency of CFRP composites create a wide range of structural applications considering the increasing lifetime of the components and joints.Highlights
Riveting of composites have negative impact on joint strentgh.
Hybrid joints using a combination of rivets and adhesives can increase the load bearing capacity.
Tensile performance strategy of joint in composites can be improved by diversification of joint combinations.
Exploring the filler morphology and temperature‐dependent compressive response of glass‐filled epoxy composites: Insights from experiments and viscoplastic simulations
Authors: Kumar Siddharth , Sahay Saurav Ranjan , Singh Sarthak S. , Rozycki Patrick 
Published: August 2024

AbstractThis study aims to improve the compressive strength of epoxy at operating temperatures below the glass transition temperature by introducing micron‐sized spherical and milled glass fillers at varying volume fractions. Test specimens were prepared by mixing spherical and milled fillers up to 20% and 15% volume fractions. The room temperature (27°C) results showed that 15% and 10% volume fractions of spherical and milled filler‐reinforced epoxy composites, respectively, exhibited the highest stress‐bearing ability among their respective filler volume fractions and hence were further tested at 45°C and 60°C. 15% spherical and 10% milled fillers enhanced epoxy's yield strength from 103 MPa to 111 MPa and 123 MPa at 27°C and from 67 MPa to 73 MPa and 80 MPa at 60°C. Scanning electron microscopic imaging revealed matrix cracking and filler breakage as the primary failure mechanisms at ambient temperature, while matrix softening at 60°C caused filler‐matrix debonding to dominate. The Three‐Network viscoplastic model was used as matrix property in ABAQUS to simulate the representative volume elements reinforced with milled and spherical fillers at mentioned temperatures. The modulus, yield, and strain softening stresses for both filler‐reinforced epoxy composites are well predicted by the simulations. Simulations revealed that milled fibers endure higher compressive stress than spherical particles at the given temperatures, although matrix stress remains almost the same.Highlights
Milled fiber epoxy composites exhibit higher yield strength than spherical ones.
10% milled fiber endures the highest strength among all the fillers used.
Matrix and filler breakages are witnessed at ambient temperature.
Filler‐matrix debonding dominates at elevated temperature.
Three‐Network model captures well the milled and spherical epoxy composite's experimental data.
Experimental Induction of Complex Gastroschisis in the Fetal Lamb: Systematic Review
Authors: Arai Tomohiro , Tianthong Wasinee , Russo Francesca Maria , Basurto David , Joyeux Luc , De Coppi Paolo , Deprest Jan 
Published: August 2024

ABSTRACTWe systematically reviewed experiments in the fetal lamb model of gastroschisis using PubMed, Embase, Web of Science, and Scopus, seeking for standardized surgical techniques to obtain complex gastroschisis. Eligible were studies where an abdominal wall defect was surgically induced and gross anatomical findings at birth were available. The primary outcome was complex gastroschisis, defined by the presence of bowel stenosis, atresia, volvulus, perforation, and/or necrosis. Secondary outcomes were fetal death and additional readouts reported. Of ten eligible studies, six included lambs that had no additional prenatal manipulations and were assessed at term (35 lambs). Gastroschisis was induced at day 70–80 (term = 140–145), typically (n = 4/6 studies) in the left lower abdomen with defect size ranging from 0.5 to 4.0 cm. Only one study, in which a 1.5 cm diameter silicone ring was utilized, resulted in complex gastroschisis in 100% of term survivors. Fetal loss was more frequent in studies where a silicone ring and/or a right‐sided defect were used. No changes unique to complex gastroschisis were identified in additional readouts, including bowel histology. When gastroschisis becomes “complex” following induction is uncertain. This knowledge is essential in studying potential prenatal interventions that may change the natural course.