bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leni Riefenstahl’s Triumph of the Will and Alain Resnais’s Night and Fog
Authors: Lothe Jacob 
Published: February 2025

Abstract
Concentrating on the narrative ethics of documentary film, chapter 2 discusses two films inspired by memories of historical events. The chapter first considers Leni Riefenstahl’s Triumph of the Will (1935), a documentary film that chronicles the 1934 Nazi Party Congress in Nürnberg. It shows that, in spite of Riefenstahl’s claims to the contrary, Triumph of the Will is thoroughly and knowingly complicit in Nazi ideology. The chapter then turns to the French director’s Alain Resnais’s Night and Fog (1956), one of the first attempts to document, and remember, the Nazi concentration camps by activating and exploring the resources of film narrative. There is, the chapter argues, a problematic tension in Night and Fog between the voiceover commentary, which hardly mentions that most of the victims of the Holocaust were Jews, and Resnais’s use of film footage from the concentration and extermination camps to which Jews were deported.
Jenny Erpenbeck’s Aller Tage Abend (The End of Days)
Authors: Lothe Jacob 
Published: February 2025

Abstract
Chapter 7 discusses how, in her novel The End of Days Aller Tage Abend (2012), Erpenbeck, via her third-person narrator whose perspective approaches those of her focalized characters, asks: what would the child who dies at the narrative’s beginning have experienced had she not died? What would have changed if she did not die? That these questions have an ethical dimension becomes obvious once the reader relates them to the Holocaust, the historical event that underlies the narrative discourse. Responding as a creative writer to her own questions, Erpenbeck reveals that the girl who died turns out to be alive after all. Erpenbeck shows how the protagonist experiences a series of wars and totalitarian regimes in twentieth-century Europe. For the narrator, whose temporal vantage point and ethical stance approximate that of Erpenbeck as implied author, the Holocaust becomes a postmemory; for the protagonist, it is a painful, traumatic memory.
Green Candle
Authors: Chesnut R Andrew 
Published: February 2025

Abstract
This chapter explores Santa Muerte’s evolving role in social and criminal justice through the symbol of the green candle. Unlike her associations with punishment or vengeance, the green candle emphasizes her support for legal matters, societal fairness, and equal justice. Santa Muerte serves as both protector and advocate for devotees, especially those navigating a flawed legal system. As a supernatural attorney, she provides relief and advocacy, crossing lines between folk Catholicism, Afro-Latin traditions, and socio-political justice. The chapter highlights the green candle’s significance in bridging the pursuit of equity and mercy, particularly for the marginalized within the Mexican judicial landscape.
‘In One Word, the Disorder is Universal’: Horses, Hounds, and Security
Authors: Jaffré Marc W S 
Published: February 2025

Abstract
Chapter 2 continues the overview of institutional development within the royal household begun in the first chapter with an analysis of the Royal Stables, the Hunting Establishment, the Military Household, and the Provostship of the Household. It emphasizes the dialogue between the king’s needs and tastes and those of his courtiers as a driver for institutional development. Even in household departments, like the Hunt, where the king’s tastes played a particularly important role, new creations and developments were often the product of courtiers attempting to anticipate Louis XIII’s tastes, rather than the monarch’s initiative. When innovations were directly instituted by the king, such as the creation of the musketeers, these creations did not correspond to overarching plans for the court, but rather were ad hoc decisions and responses to specific contingencies. The chapter reveals how disputes were frequently the mechanism through which institutional development occurred. Cardinal Richelieu’s criticisms of and aspersions directed towards Louis XIII’s household were the product of a disconnect between the French court’s familiar culture and Richelieu’s fantasies of clearly delineated hierarchies, which would have made the court easier to control.
‘In Bravery, Diet, and Furniture, They Exceed the Greatest of the Noblesse’: Finance and Financiers
Authors: Jaffré Marc W S 
Published: February 2025

Abstract
Chapter 6 deals with the cost of the court, court finance and accounting practices, and the place held by financiers within court society. The chapter demonstrates that the cost of the court remained more or less constant over the course of Louis XIII’s reign, that court expenses were increasingly dwarfed by the ballooning costs of warfare, and that the court’s cost was rarely the focus of public criticism. The court’s expenses were administered by a variety of accountants who employed myriad accounting practices to face the challenges posed by their management of royal expenditure. This analysis reveals the extent to which the accountants themselves were behind the elaboration and clarification of rules on how officers should be paid, as well as how invested the heads of household departments were in their authority over the expenditure and accounting of their departments. Major institutional innovations, though fuelled by financial exigencies, did not follow a logic of modernization or rationalization but were designed to produce one-off windfalls. The chapter additionally shows that financiers and accountants were active participants in court life, serving the king’s meals, participating in his hunts, leveraging their fortunes for political advantage, and seeking favourable marriages with the sword nobility for their daughters. Despite this strong attachment to the court, the monarchy often resorted to the blackmail and extortion of financial officers in order to fill its coffers. This was not a solid basis for financing the state’s expenditure and often led in the longer term to bankruptcies and severe disruption of royal finance.
‘The God of the Race’: Louis XIII and his Itinerant Court
Authors: Jaffré Marc W S 
Published: February 2025

Abstract
Chapter 8 is concerned with the peripatetic nature of Louis XIII’s court. It highlights just how extensive and frequent Louis’s voyages were, challenging narratives that the court was becoming increasingly fixed in Paris. It reveals the physical dangers the court faced while on the move, the extent to which Louis’s progresses impeded the natural running of government, and the devastating impact the court could have on the towns it sojourned in. However, progresses could not be avoided as they continued to be vital tools for exerting political pressure, securing provinces, meeting with other sovereigns, building relationships with notables and provinces, and responding to political and security imperatives. Progresses allowed the court to participate in royal entries, the organization of which French monarchs had more influence over than has often been assumed. The chapter also exposes the complex mechanisms that underpinned the court’s travels, securing lodgings for and supplying the court during its travels. Even when the court remained in the Île-de-France region, it was by no means fixed, and Louis split his time across a variety of palaces, the most important of which were the Louvre in Paris, Fontainebleau, and the two châteaux of Saint-Germain-en-Laye. As the reign wore on, the king spent less and less time in Paris and more time in Fontainebleau and Saint-Germain-en-Laye, fuelling the construction of noble palaces in these two towns. Cardinal Richelieu sought to establish his own separate nexus of power in Rueil not far from Saint-Germain-en-Laye and Versailles, accentuating the polycentric nature of the court and undermining royal prestige.
The emerging role and therapeutical implications of ferroptosis in wound healing
Authors: Zhao Yanan , Chen Zhiyang , Xie Shenghao , Xiao Feng , Hu Qian , Ju Zhenyu 
Published: February 2025

Abstract
Wound healing is a complex biological process involving multiple steps, including hemostasis, inflammation, proliferation, and remodeling. A novel form of regulated cell death, ferroptosis, has garnered attention because of its involvement in these processes. Ferroptosis is characterized by the accumulation of lipid peroxides and is tightly regulated by lipid metabolism, iron metabolism, and the lipid-peroxide repair network, all of which exert a significant influence on wound healing. This review highlights the current findings and emerging concepts regarding the multifaceted roles of ferroptosis throughout the stages of normal and chronic wound healing. Additionally, the potential of targeted interventions aimed at modulating ferroptosis to improve wound-healing outcomes is discussed.
Functional characterization of Type IV basal cells in rat fungiform taste buds
Authors: Bigiani Albertino , Tirindelli Roberto , Rhyu Mee Ra , Mapelli Jonathan 
Published: February 2025

Abstract
Taste buds, the end organs of taste, consist of a diverse population of sensory cells that is constantly renewed. Cell differentiation begins with Type IV basal cells, which are ovoid elements located inside the taste bud near its base. These cells are post-mitotic precursors that give rise to all other cell types, including glial-like cells (Type I cells) and chemoreceptors (Type II and Type III cells). Despite their critical role in cell turnover, Type IV basal cells are relatively unknown in terms of functional features. Here, we used Lucifer yellow labelling and patch-clamp technique to investigate their electrophysiological properties in the rat fungiform taste buds. All Type IV basal cells showed voltage-gated sodium currents (INa), albeit at a far lower density (17 pA/pF) than chemoreceptors (444 pA/pF), which fire action potentials during sensory transduction. Furthermore, they lacked calcium homeostasis modulator (CALHM) currents, which are required for neurotransmitter release by some chemoreceptor types. Amiloride-sensitive epithelial sodium channel (ENaC) was found to be only present in a subset of Type IV basal cells. Interestingly, Type IV basal cells shared some membrane features with glial-like cells, such as high cell capacitance and low INa density; however, input resistance was greater in Type IV basal cells than in glial-like cells. Thus, although Type IV basal cells may eventually differentiate into distinct cell lineages, our findings indicate that they are quite homogeneous in terms of the electrophysiological characteristics, with the exception of functional ENaCs, which appear to be only expressed in one subset.
Pleiotropic regulation of bacterial toxin production and Allee effect govern microbial predator–prey interactions
Authors: Suma Harikumar R , Stallforth Pierre 
Published: February 2025

Abstract
Bacteria are social organisms, which are constantly exposed to predation by nematodes or amoebae. To counteract these predation pressures, bacteria have evolved a variety of potent antipredator strategies. Bacteria of the genus Pseudomonas, for instance, evade amoebal predation by the secretion of amoebicidal natural products. The soil bacterium Pseudomonas fluorescens HKI0770 produces pyreudione alkaloids that can kill amoebae. Even though the mode of action of the pyreudiones has been elucidated, the spatiotemporal dynamics underlying this predator–prey interaction remain unknown. Using a combination of microscopy and analytical techniques, we elucidated the intricate relationship of this predator–prey association. We used the chromatic bacteria toolbox for intraspecific differentiation of the amoebicide-producing wildtype and the non-producing mutant within microcosms. These allow for variations in nutrient availability and the emergence of predation-evasion strategies of interacting microorganisms. Imaging of the co-cultures revealed that the amoebae initially ingest both the non-producer as well as the toxin-producer cells. The outcomes of predator–prey interactions are governed by the population size and fitness of the interacting partners. We identified that changes in the cell density coupled with alterations in nutrient availability led to a strong Allee effect resulting in the diminished production of pyreudione A. The loss of defence capabilities renders P. fluorescens HKI0770 palatable to amoebae. Such a multifaceted regulation provides the basis for a model by which predator–prey populations are being regulated in specific niches. Our results demonstrate how the spatiotemporal regulation of bacterial toxin production alters the feeding behaviour of amoeba.
Immuno-epidemiologic mapping of HLA diversity across glioma patient cohorts
Authors: Xiong Zujian , Walsh Kyle M , Sneiderman Chaim T , Nisnboym Michal , Hadjipanayis Costas G , Agnihotri Sameer , Eagar Todd N , Wang Hong , Pollack Ian F , Forsthuber Thomas G , Li Xuejun , Raphael Itay , Kohanbash Gary 
Published: February 2025

Abstract

Background
Individual-level characteristics underlying population-level variation in glioma risk and outcomes remain incompletely understood. Cancer immunosurveillance, host immunity, and some immunotherapies center on the ability of an individual’s immune cells to recognize antigen epitopes presented on MHC molecules. Inter-individual variation in HLA alleles can elicit distinct repertoires of tumor antigen for presentation to immune cells. Therefore, HLA alleles may impact glioma incidence and prognosis.

Methods
HLA class I (HLA-I) alleles were identified using sequencing data from four large glioma cohorts and healthy cohorts, matched on ancestry, and race- and age-matched imputed cohorts developed by the Hardy-Weinberg equilibrium were referred to determine odds ratio incidence estimated by logistic regression. HLA prognostication was quantified by Cox regression.

Results
We analyzed 1,215 cases of glioma patients from non-Hispanic Whites and Asians. The HLA-I allelic frequencies of gliomas generally corresponded to their distribution within each race. However, specific HLA-I alleles were significantly associated with glioma incidence and prognosis, which differ between races but were independent of age and sex. Notably, non-Hispanic White glioma patients exhibited greater HLA homozygosity rates compared with race-matched controls. HLA-C01:02 and HLA-C07:02 displayed opposing effects on glioma prognosis between races. The distinct effects were associated with their capability of presenting specific mutations that appeared at the initial or late phase of glioma progression.

Conclusions
Expression of specific HLA-I alleles are associated with glioma incidence and prognosis within race. HLA-I-homozygosity is a risk factor for glioma in non-Hispanic Whites. These findings may guide development of precision-guided immunotherapies for glioma.
Local tumor control and neurological outcomes after surgery for spinal hemangioblastomas in sporadic and Von-Hippel-Lindau Disease: A multicenter study
Authors: Wach Johannes , Basaran Alim Emre , Vychopen Martin , Tihan Tarik , Wostrack Maria , Butenschoen Vicki M , Meyer Bernhard , Siller Sebastian , Schmidt Nils Ole , Onken Julia , Vajkoczy Peter , Santos Alejandro N , Rauschenbach Laurèl , Dammann Philipp , Sure Ulrich , Klingler Jan-Helge , Doria-Medina Roberto , Beck Jürgen , Blaß Bianca-Ioana , Gizaw Christine Juliane , Hohenhaus Romina , Krieg Sandro , Alhalabi Obada T , Klein Lukas , Thomé Claudius , Kögl Nikolaus , Kunert Przemyslaw , Czernicki Tomasz , Pantel Tobias , Middelkamp Maximilian , Eicker Sven Oliver , Kattaa Ahed H , Park David J , Chang Steven D , Kilinc Fatma , Czabanka Marcus , Güresir Erdem 
Published: February 2025

Abstract

Background
Spinal hemangioblastomas (sHBs) are rare vascular tumors with significant neurological implications. Their management, particularly in von Hippel-Lindau (VHL) disease, remains challenging due to recurrence and functional decline. Timely identification and intervention are critical for optimal outcomes.

Methods
This international, multicenter retrospective cohort study included 357 patients (199 VHL-associated, 158 sporadic) from 13 neuro-oncological centers. Clinical and imaging data were analyzed to assess progression-free survival (PFS) and functional outcomes using the Modified McCormick Scale (mMCS) at 12 months. Secondary analyses identified factors associated with VHL disease in sHBs.

Results
Complete resection (CR) was achieved in 87.7% of cases, leading to significantly improved PFS at 72 months (sporadic: 95.1%, VHL-associated: 91.1%; HR: 0.18, 95%CI: 0.08–0.4). Multivariable analysis identified predictors of unfavorable outcomes at 12 months: Preoperative mMCS ≥2 (OR: 5.17, p=0.008), intramedullary tumor location (OR: 9.48, p=0.01), and preoperative bleeding (OR: 31.12, p=0.02). Factors independently associated with VHL disease in sHBs included non-cervical tumor location (OR: 2.08, p=0.004), intramedullary growth (OR: 2.39, p&lt;0.001), and age &lt;43 years (OR: 3.24, p&lt;0.001). Functional improvements were observed in most patients, particularly those with sporadic sHBs.

Conclusions
Complete surgical resection is essential for long-term tumor control and favorable functional outcomes in both sporadic and VHL-associated sHBs. Early intervention, particularly in mild symptomatic and progressive cases, before neurological deterioration or hemorrhage, optimizes recovery. This study, the largest of its kind in a multicentric international setting, provides robust evidence to guide the management of both sporadic and VHL-associated sHBs.
Smart Kanata: A framework for autonomous decision-making in rapid follow-up observations of cataclysmic variables
Authors: Uemura Makoto , Koga Yuzuki , Sazaki Ryosuke , Yukino Tomoya , Nakaoka Tatsuya , Imazawa Ryo , Kato Taichi , Nogami Daisaku , Isogai Keisuke , Kojiguchi Naoto , Taguchi Kenta , Tampo Yusuke , Maehara Hiroyuki , Ikeda Shiro 
Published: February 2025

Abstract
Studying the early stages of transient events provides crucial information about the fundamental physical processes in cataclysmic variables (CVs). However, determining an appropriate observation mode immediately after the discovery of a new transient presents challenges due to significant uncertainties regarding its nature. We developed a framework designed for autonomous decision-making in prompt follow-up observations of CVs using the Kanata $1.5$ m telescope. The system, named Smart Kanata, first estimates the class probabilities of variable star types using a generative model. It then selects the optimal observation mode from three possible options based on the mutual information calculated from the class probabilities. We have operated the system for ${\sim}300$ d and obtained 21 samples, among which automated observations were successfully performed for a nova and a microlensing event. In the time-series spectra of the nova V4370 Oph, we detected a rapid deepening of the absorption component of the H$\alpha$ line. These initial results demonstrate the capability of Smart Kanata in facilitating rapid observations and improving our understanding of outbursts and eruptions of CVs and other galactic transients.
A case of pembrolizumab-induced bullous pemphigoid treated with dupilumab
Authors: Rossi Agnese , Brancorsini Donatella , Gioacchini Helena , Campanati Anna 
Published: February 2025

Abstract
Immune checkpoint inhibitors are a class of drugs used in cancer treatment that promote the immune system’s response by blocking the inhibitor signals from tumour cells, such as PD-1/PD-L1 and CTLA-4. Despite their clinical benefit, these monoclonal antibodies unspecifically activate the immune system and can lead to the development of ‘immune-related adverse events’. Cutaneous toxicities are the most frequent immune-related adverse events, reported in approximately 30–50% of patients treated with immunotherapy; the most common dermatologic toxicities are represented by rash, vitiligo, pruritus and lichenoid reactions. Usually these reactions are mild and it is not necessary to suspend immunotherapy. Potentially life-threatening skin toxicities, such as immunobullous eruption, are rare and may appear in approximately 1% of patients. In this report we describe a case of bullous pemphigoid, the most frequent bullous disease, that developed after treatment with pembrolizumab for a metastatic melanoma. The diagnosis, first suspected by the referring clinic, was confirmed by performing serology and biopsy with direct immunofluorescence. At the beginning, the patient was treated with high doses of systemic corticosteroids, without suspending the immunotherapy treatment. Subsequently, due to the continuous relapses, we decided to suspend pembrolizumab and systemic corticosteroid and to begin an off-label treatment with dupilumab. The following case gives cause for reflection about the management of a drug-induced disease in a immunocompromised patient, while exploring his therapeutic options.
An immunoregulatory amphipathic peptide derived from Fasciola hepatica helminth defense molecule (FhHDM‐1.C2) exhibits potent biotherapeutic activity in a murine model of multiple sclerosis
Authors: Lalor Richard , Tanaka Akane , Shiels Jenna , Dixit Aakanksha , Hoadley Sabine , Dufourd Eloïse , Hamon Siobhan , To Joyce , Taggart Clifford C. , Weldon Sinead , O'Brien Bronwyn , Greer Judith , Dalton John P. , Donnelly Sheila 
Published: February 2025

AbstractThe helminth defense molecules (HDM) are a family of immune regulatory peptides exclusively expressed by trematode worms. We have previously demonstrated that in vivo FhHDM‐1, the archetypal member of the HDMs, regulated macrophage responses to inflammatory ligands, thereby ameliorating the progression of immune‐mediated tissue damage in several murine models of inflammatory disease. Accordingly, we postulated that an understanding of the structure–function relationship of the HDMs would facilitate the identification of the minimal bioactive peptide, which would represent a more synthesizable, cost‐effective, potent biotherapeutic. Thus, using a combination of bioinformatics, structural analyses, and cellular assays we discovered a 40 amino acid peptide derivative termed FhHDM‐1.C2. This peptide contains a 12 amino acid motif at its N‐terminus, which facilitates cellular interaction and uptake, and an amphipathic α‐helix within the C‐terminus, which is necessary for lysosomal vATPase inhibitory activity, with both regions linked by a short unstructured segment. The FhHDM‐1.C2 peptide exhibits enhanced regulation of macrophage function, compared with the full‐length FhHDM‐1, and potent prevention of the progression of relapsing–remitting‐experimental autoimmune encephalomyelitis (EAE) when administered prophylactically or therapeutically. The protective effect of FhHDM‐1.C2 is not associated with global immune suppression, which places the HDMs peptides as an improved class of biotherapeutics for the treatment of inflammatory diseases. Comparing the HDMs from several zoonotic trematodes revealed a similar capacity for immune regulation. These important new advances into the structure–function relationship of the lead HDM peptide, FhHDM‐1, encourage further prospecting and screening of the broader trematode family of peptides for the discovery of novel and potent immune‐biotherapeutics.