bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘EINE WIRKLICHE MÄRCHENERZÄHLERIN’? THE SHORT PROSE OF ERNST ROSMER
Authors: Gillett Robert 
Published: September 2015

ABSTRACTA serious problem with many previous accounts of the German short prose form in the nineteenth century is that they fail to take into account the vital contribution made by women to the genre. Equally, it is often forgotten just how crucial the ‘Kunstmärchen’ was in this regard. This essay seeks to address this problem by examining in some detail the prose works of Elsa Bernstein, née Porges, who wrote as Ernst Rosmer. Rosmer is known, if she is known at all, as a dramatist of the naturalist school. But she owed her greatest success to a fairy‐tale opera set to music by Engelbert Humperdinck, the composer of Hänsel und Gretel. And she also published a volume of ‘Novellen’, as well as contributing works in the short form to a number of periodicals. Together, this small but impressive body of work – and its reception – offer exemplary insights into an often neglected aspect of German short prose in the nineteenth century.In bisherigen Darstellungen der deutschsprachigen Kurzprosa im neunzehnten Jahrhundert vermisst man allzu oft eine angemessene Würdigung des Beitrags, den Frauen gerade auf diesem Gebiet geleistet haben. Hinzu kommt, dass man die überaus wichtige Rolle, die das Kunstmärchen in diesem Zusammenhang gespielt hat, nicht immer gebührlich anerkennt. In einem Versuch, auf diesen Tatbestand wenigstens aufmerksam zu machen, soll hier die Kurzprosa von Elsa Bernstein, geborene Porges, unter die Lupe genommen werden, einer Schriftstellerin, die unter dem Namen Ernst Rosmer bekannt wurde. Von Rosmer kennt man heutzutage, wenn überhaupt, eigentlich nur die Dramen, die zum Naturalismus gezählt werden. Ihren größten Erfolg aber erzielte sie als Librettistin einer Märchenoper, die von Engelbert Humperdinck, dem Komponisten des Hänsel und Gretel, vertont wurde. Außerdem veröffentlichte sie einen Band mit Novellen und brachte manche Stücke Kurzprosa in den Zeitschriften der Zeit unter. Diese Werke – und ihre Rezeption – werfen exemplarisches Licht auf bisher ungenügend erforschte Aspekte der deutschsprachigen Kurzprosa im neunzehnten Jahrhundert.
THE REWRITING OF LOU ANDREAS‐SALOMÉ’S EINE AUSSCHWEIFUNG
Authors: Holmes Deborah 
Published: September 2015

ABSTRACTLou Andreas‐Salomé made her presence felt on the early Modernist literary scene with an intense production of novellas in the late 1890s. She then published no more fiction for almost two decades, a period during which she concentrated her energies on sexology and psychoanalysis. The essay examines her ambivalent attitude to her own works in the light of her theoretical and private pronouncements on the unsuitability of women to be creative artists. It then seeks to illustrate the importance of genre to her narrative oeuvre with a detailed analysis of Eine Ausschweifung, one of her earliest novellas, which features a successful, independent woman artist as self‐reflective, first‐person protagonist. Particular emphasis is laid on the substantial differences between its periodical publication in 1897 under the title Ein überlebter Traum and its book publication in 1898. The novella's re‐crafting, analysed here with reference to its author's interaction with Rilke and Max Klinger, but also to Hermann Bahr's appeal for a ‘new psychology’, shows how Andreas‐Salomé experimented with the possibilities of the short form between Naturalism and Modernism.Lou Andreas‐Salomé wurde als Schriftstellerin der frühen Moderne hauptsächlich dank ihrer intensiven Novellenproduktion in den späten 1890er Jahren wahrgenommen. Nach der Jahrhundertwende hörte sie auf, Belletristik zu publizieren, um sich zwei Jahrzehnte lang mit der ihr charakteristischen Konsequenz der Sexualwissenschaft und der Psychoanalyse zu widmen. Der Aufsatz geht ihrer durchaus ambivalenten Einstellung zu den eigenen literarischen Werken nach, indem er Bezug auf ihre theoretischen und privaten Aussagen über die Untauglichkeit des ‘Weibes’, sich künstlerisch zu betätigen, nimmt. Anschließend wird die Wichtigkeit der Gattungsunterschiede in ihrem erzählerischen Werk anhand einer detaillierten Analyse der Novelle Eine Ausschweifung untersucht, deren Hauptfigur eine erfolgreiche, unabhängige Künstlerin ist, die als Ich‐Erzählerin die eigene Geschichte in die Hand nimmt. Dabei wird besonderes Augenmerk auf die zwei verschiedenen Versionen der Novelle gelegt: 1897 wurde sie unter dem Titel Ein überlebter Traum als Seriennovelle in einer Zeitschrift veröffentlicht; 1898 erschien sie völlig überarbeitet in Buchform. Die Überarbeitung wird hier im Zusammenhang mit Rilke und Max Klinger analysiert, auch unter Berücksichtigung von Hermann Bahrs Ruf nach einer ‘neuen Psychologie’ in seinem ‘Versuch über die Moderne’. So wird gezeigt, wie Andreas‐Salomé auf der Kippe zwischen Naturalismus und Moderne mit den Möglichkeiten der ‘kleinen Form’ experimentierte.
The determination of the radical power – an in vitro test for the evaluation of cosmetic products
Authors: Herrling T. , Seifert M. , Sandig G. , Jung K. 
Published: September 2015

SynopsisObjectiveCosmetic formulations are influenced by environmental impacts and ageing, resulting in rancidity and change of colour and structure. These changes are caused by free radicals (FRs). The sensitivity of cosmetics generating FRs is a metric for its quality and should be determined.MethodsElectron spin resonance spectroscopy in combination with UV irradiation tested cosmetics such as creams, milks, lotions and fragrances. The probes were directly measured without expensive preparation.ResultsNine formulations are tested for its radical generation and ranked corresponding to the radical power. The transformation of the FR properties of three formulations to skin is measured by the radical skin status factor (RSF) method. It shows that the higher the radical power (RP) is, the lower the radical status RSF of skin will be.ConclusionThe knowledge of the sensitivity of cosmetics to generate FRs is necessary for its stabilization and prevention of potential damages to skin. It is a new way in development of cosmetics which has to be considered.
Safety and retention of combination triple disease‐modifying anti‐rheumatic drugs in new‐onset rheumatoid arthritis
Authors: Cummins L. , Katikireddi V. S. , Shankaranarayana S. , Su K. Y. C. , Duggan E. , Videm V. , Pahau H. , Thomas R. 
Published: September 2015

AbstractBackgroundWhile efficacy of combination treatment with methotrexate (MTX), sulfasalazine (SSZ) and hydroxychloroquine (HCQ) (‘triple therapy’) has been shown in clinical trials, few studies have examined its longevity in a real‐life setting.AimOur aim was to assess the tolerability, longevity and efficacy of a triple disease‐modifying anti‐rheumatic drug (DMARD) regimen initiated in new‐onset rheumatoid arthritis (RA) patients.MethodsPatients who met 1987 American College of Rheumatology criteria for RA with disease duration less than 2 years were offered triple therapy upon diagnosis. Treatment was intensified according to a response‐driven step‐up algorithm, which included progression to leflunomide (LEF) or a biologic agent.ResultsOf 181 new‐onset RA patients, 119 commenced triple therapy. Median duration of triple therapy was 39 weeks, and 23.5% remained on it at last follow up, with median follow up 104 weeks. Continuous therapy with any three‐DMARD combination (including LEF) occurred in 32% at last follow up, with median duration of 70 weeks. Cessation of at least one of MTX, SSZ or HCQ occurred because of an adverse event in 38%, remission in 7% and incomplete response in 28% of patients. SSZ accounted for 49% of initial drug withdrawals for an adverse event. Continuation of three‐drug therapy did not significantly influence the proportion of patients achieving remission or low disease activity (LDA).ConclusionsTriple therapy in new‐onset RA was reasonably well tolerated, persisting for median 39 weeks. SSZ intolerance commonly reduces longevity of triple therapy. Treating to the target of remission or LDA is more important than the number of DMARD continued.
Physician substitution by mid‐level providers in primary healthcare for older people and long‐term care facilities: protocol for a systematic literature review
Authors: Lovink Marleen H. , Persoon Anke , van Vught Anneke J.A.H. , Koopmans Raymond T.C.M. , Schoonhoven Lisette , Laurant Miranda G.H. 
Published: September 2015

AbstractAimThis protocol describes a systematic review that evaluates the effects of physician substitution by mid‐level providers (nurse practitioners, physician assistants or nurses) in primary healthcare for older people and long‐term care facilities. The secondary aim is to describe facilitators and barriers to the implementation of physician substitution in these settings.BackgroundHealthcare for older people is undergoing major changes, due to population ageing and reforms that shift care to the community. Besides, relatively few medical students are pursuing careers in healthcare for older people. Innovative solutions are needed to guarantee the quality of healthcare and to contain costs. A solution might be shifting care from physicians to mid‐level providers. To date, no systematic review on this topic exits to guide policymaking.DesignA quantitative systematic literature review using Cochrane methods.MethodsThe following databases will be searched for original research studies that quantitatively compare care provided by a physician to the same care provided by a mid‐level provider: PubMed, EMBASE, CINAHL, PsycINFO, CENTRAL and Web of Science. Study selection, data extraction and quality appraisal will be conducted independently by two reviewers. Data synthesis will consist of a qualitative analysis of the data. Funding of the review was confirmed in August 2013 by the Ministry of Health, Welfare and Sport of the Netherlands.DiscussionThis review will contribute to the knowledge on effects of physician substitution in healthcare for older people and factors that influence the outcomes. This knowledge will guide professionals and policy administrators in their decisions to optimize healthcare for older people.
The Evolution of Individual Maternity Care Providers to Delayed Cord Clamping: Is It the Evidence?
Authors: Leslie Mayri Sagady , Erickson‐Owens Debra , Cseh Maria 
Published: September 2015

IntroductionStudies of organizational strategies to incorporate evidence into practice and change provider behavior have shown limited success. The majority of existing research centers on influencing participants to change practice versus understanding what occurs when providers have successfully shifted to an evidence‐based practice on their own. This study sought to explore the dynamics involved when individual midwives and physicians transitioned from a practice less based on the evidence to one with more scientific support. Delayed cord clamping was selected as the exemplar practice for the study.MethodsA qualitative grounded theory approach was used. Seventeen providers were interviewed throughout the United States. This included 5 physicians and 12 midwives from a variety of practice configurations and birth settings including the home, birth center, and hospital.ResultsFive themes arose from the stories of the participants: 1) trusting colleagues, 2) believing the evidence, 3) honoring mothers and families, 4) knowing personal certainty, and 5) protecting the integrity of the mother and the baby. The themes served as drivers of change for the providers in what emerged as an evolution toward change rather than a decision to change. From the themes, the model for individual evolution to evidence‐based practice was developed.DiscussionImportant findings included the significant role that colleagues play in an individual's journey toward a new practice, the fact that the evidence alone was never a sole driver of change, and the emergence of a discourse: Who owns the baby? The model developed as a result of this study provides a new framework for both future research and potential strategies to support the incorporation of evidence into practice.
Identification of Intrastent Pathology Associated With Late Stent Thrombosis Using Optical Coherence Tomography
Authors: Jones Christopher R. , Khandhar Sameer J. , Ramratnam Mohun , Mulukutla Suresh R. , Marroquin Oscar C. , Althouse Andrew D. , Rao Anjali , Kato Koji , Jang Ik‐Kyung , Toma Catalin 
Published: September 2015

ObjectiveTo better characterize intrastent pathology using optical coherence tomography (OCT) in patients presenting with late and very late stent thrombosis (LST/VLST).BackgroundThe contribution of specific intrastent pathologies to the development of LST/VLST is not well understood.MethodsIn this single‐center, retrospective, observational study of 796 consecutive patients treated for ST‐segment elevation myocardial infarction (STEMI) with primary PCI we identified 57 patients (7.2%) in whom STEMI resulted from LST/VLST. Of the patients with LST/VLST, 21 patients (37%) had OCT performed at the discretion of the operator during PCI for LST/VLST. Independent reviewers performed qualitative offline analysis of OCT images to determine the cause of stent thrombosis defined as the specific intrastent pathology associated with thrombus deposition.ResultsThe principal intrastent pathology causing LST/VLST was determined to be stent malapposition in 11 patients (55%), of which 5 (25% of all LST/VLST patents) had findings suggestive of positive vessel remodeling. Neoatherosclerosis was determined to be the cause of LST/VLST in 7 patients (35%). LST/VLST resulted from uncovered stent struts in 2 patients (10%). Among all LST/VLST patients, in‐hospital mortality (12.3%) and post‐hospital target vessel failure (TVF) or cardiac death (21.7%, median follow‐up 1.6 years) remained high. There was a trend towards decreased TVF or cardiac death (7.7% vs. 27.3% P = 0.24) in patients who underwent OCT‐guided therapy.ConclusionsLST/VLST remains a significant cause of STEMI and is associated with considerable morbidity and mortality. OCT use at the time of PCI consistently identifies significant intrastent pathology with potentially meaningful clinical impact. (J Interven Cardiol 2015;28:439–448)
Finished Genome Assembly of Warm Spring Isolate Francisella novicida DPG 3A-IS
Authors: Johnson Shannon L. , Minogue Timothy D. , Daligault Hajnalka E. , Wolcott Mark J. , Teshima Hazuki , Coyne Susan R. , Davenport Karen W. , Jaissle James G. , Chain Patrick S. 
Published: September 2015

ABSTRACT

We sequenced the complete genome of
Francisella novicida
DPG 3A-IS to closed and finished status. This is a warm spring isolate recovered from Hobo Warm Spring (Utah, USA). The final assembly is available in NCBI under accession number CP012037.
Complete Sequence of a
bla
OXA-48
-Harboring IncL Plasmid from an Enterobacter cloacae Clinical Isolate
Authors: Manageiro Vera , Pinto Margarida , Caniça Manuela 
Published: September 2015

ABSTRACT

We report a 63,584-bp conjugative IncL plasmid (pUR17313-1) from an
Enterobacter cloacae
clinical isolate, containing a
bla
OXA-48
gene. The plasmid sequence also carried important mobile genetic elements involved in the spread of antibiotic resistance, namely, the Tn
1999
.
2
composite transposon, which enclosed
bla
OXA-48
-, integrase-, and transposase-encoding genes.
The effect of Tai Chi on four chronic conditions—cancer, osteoarthritis, heart failure and chronic obstructive pulmonary disease: a systematic review and meta-analyses
Authors: Chen Yi-Wen , Hunt Michael A , Campbell Kristin L , Peill Kortni , Reid W Darlene 
Published: September 2015

BackgroundMany middle-aged and older persons have more than one chronic condition. Thus, it is important to synthesise the effectiveness of interventions across several comorbidities. The aim of this systematic review was to summarise current evidence regarding the effectiveness of Tai Chi in individuals with four common chronic conditions—cancer, osteoarthritis (OA), heart failure (HF) and chronic obstructive pulmonary disease (COPD).Methods4 databases (MEDLINE, EMBASE, CINAHL and SPORTDiscus) were searched for original articles. Two reviewers independently screened the titles and abstracts and then conducted full-text reviews, quality assessment and finally data abstraction. 33 studies met the inclusion criteria. Meta-analyses were performed on disease-specific symptoms, physiological outcomes and physical performance of each chronic condition. Subgroup analyses on disease-specific symptoms were conducted by categorising studies into subsets based on the type of comparison groups.ResultsMeta-analyses showed that Tai Chi improved or showed a tendency to improve physical performance outcomes, including 6-min walking distance (6MWD) and knee extensor strength, in most or all four chronic conditions. Tai Chi also improved disease-specific symptoms of pain and stiffness in OA.ConclusionsThe results demonstrated a favourable effect or tendency of Tai Chi to improve physical performance and showed that this type of exercise could be performed by individuals with different chronic conditions, including COPD, HF and OA.
New IceCube data and color octet neutrino interpretation of the PeV energy events
Authors: Akay A. N. , Cakir O. , Gunaydin Y. O. , Kaya U. , Sahin M. , Sultansoy S. 
Published: September 2015

IceCube collaboration has published two papers on ultrahigh energy neutrinos observation, recently. They have used the data collected in two years in their first publication, which reveals observation of 2 PeV energy neutrino events. The second publication of the collaboration including more data has also confirmed main features of the former paper. In literature, various interpretations of the IceCube data have been proposed. In this study, it is shown that PeV energy neutrino events observed by the IceCube collaboration can be interpreted as resonance production of color octet neutrinos with masses in 500–800 GeV range.
Inhibition of Diaphanous Formin Signaling In Vivo Impairs Cardiovascular Development and Alters Smooth Muscle Cell Phenotype
Authors: Weise-Cross Laura , Taylor Joan M. , Mack Christopher P. 
Published: September 2015

Objective—
We and others have previously shown that RhoA-dependent stimulation of myocardin-related transcription factor nuclear localization promotes smooth muscle cell (SMC) marker gene expression. The goal of this study was to provide direct in vivo evidence that actin polymerization by the diaphanous-related formins contributes to the regulation of SMC differentiation and phenotype.

Approach and Results—

Conditional Cre-based genetic approaches were used to overexpress a well-characterized dominant-negative variant of mDia1 (DNmDia) in SMC. DNmDia expression in SM22-expressing cells resulted in embryonic and perinatal lethality in ≈20% of mice because of defects in myocardial development and SMC investment of peripheral vessels. Although most DNmDia
+
/SM22Cre
+
mice exhibited no overt phenotype, the re-expression of SMC differentiation marker gene expression that occurs after carotid artery ligation was delayed, and this effect was accompanied by a significant decrease in myocardin-related transcription factor-A nuclear localization. Interestingly, neointima growth was inhibited by expression of DNmDia in SMC and this was likely because of a defect in directional SMC migration and not to defects in SMC proliferation or survival. Finally, by using the tamoxifen-inducible SM MHC-CreER
T2
line, we showed that SMC-specific induction of DNmDia in adult mice decreased SMC marker gene expression.

Conclusions—
Our demonstration that diaphanous-related formin signaling plays a role in heart and vascular development and the maintenance of SMC phenotype provides important new evidence that Rho/actin/myocardin-related transcription factor signaling plays a critical role in cardiovascular function.
Trail Making Test Elucidates Neural Substrates of Specific Poststroke Executive Dysfunctions
Authors: Muir Ryan T. , Lam Benjamin , Honjo Kie , Harry Robin D. , McNeely Alicia A. , Gao Fu-Qiang , Ramirez Joel , Scott Christopher J.M. , Ganda Anoop , Zhao Jiali , Zhou X. Joe , Graham Simon J. , Rangwala Novena , Gibson Erin , Lobaugh Nancy J. , Kiss Alex , Stuss Donald T. , Nyenhuis David L. , Lee Byung-Chul , Kang Yeonwook , Black Sandra E. 
Published: September 2015

Background and Purpose—
Poststroke cognitive impairment is typified by prominent deficits in processing speed and executive function. However, the underlying neuroanatomical substrates of executive deficits are not well understood, and further elucidation is needed. There may be utility in fractionating executive functions to delineate neural substrates.

Methods—
One test amenable to fine delineation is the Trail Making Test (TMT), which emphasizes processing speed (TMT-A) and set shifting (TMT-B-A difference, proportion, quotient scores, and TMT-B set-shifting errors). The TMT was administered to 2 overt ischemic stroke cohorts from a multinational study: (1) a chronic stroke cohort (N=61) and (2) an acute–subacute stroke cohort (N=45). Volumetric quantification of ischemic stroke and white matter hyperintensities was done on magnetic resonance imaging, along with ratings of involvement of cholinergic projections, using the previously published cholinergic hyperintensities projections scale. Damage to the superior longitudinal fasciculus, which colocalizes with some cholinergic projections, was also documented.

Results—

Multiple linear regression analyses were completed. Although larger infarcts (
β
=0.37,
P
<0.0001) were associated with slower processing speed, cholinergic hyperintensities projections scale severity (
β
=0.39,
P
<0.0001) was associated with all metrics of set shifting. Left superior longitudinal fasciculus damage, however, was only associated with the difference score (
β
=0.17,
P
=0.03). These findings were replicated in both cohorts. Patients with ≥2 TMT-B set-shifting errors also had greater cholinergic hyperintensities projections scale severity.

Conclusions—
In this multinational stroke cohort study, damage to lateral cholinergic pathways and the superior longitudinal fasciculus emerged as significant neuroanatomical correlates for executive deficits in set shifting.
Extended Simulation of Tropical Cyclone Formation in the Western North Pacific Monsoon Trough
Authors: Wu Liguang , Duan Jingjing 
Published: September 2015

Abstract
Previous studies suggest that the low-frequency background makes an important contribution to the predictability of tropical cyclone (TC) activity on the intraseasonal time scale by providing large-scale conditions favorable for TC formation. Extended numerical experiments were conducted to demonstrate additional low-frequency influence on TC activity, which results from the development of a synoptic-scale wave train. The cyclonic circulation of the wave train provides low-level synoptic-scale disturbances for TC formation.
The observed TC formation events over the western North Pacific during 14 August–10 September 2004 were first successfully simulated with the initial and lateral conditions derived from the National Centers for Environmental Prediction (NCEP) Final (FNL) Operational Global Analysis. Then the 27-day extended experiment was repeated only with the initial and lateral boundary conditions derived from the FNL low-frequency (longer than 20 days) background. It is found that the development of the synoptic-scale wave train can be well simulated with TCs forming in the cyclonic circulations of the wave train although the wavelength of the simulated wave train is substantially reduced in the absence of higher-frequency influences with periods shorter than 20 days. Sensitivity experiments indicate that the development of wave trains is sensitive to the initial monsoon trough structure. This study suggests that the synoptic-scale wave train can develop in situ and does not need upstream precursors.