bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulación analítica para el cálculo de tableros bijácena con solicitación excéntrica
Authors: HENCHE BLANCO JAVIER 
Published: July 2024

Se presenta un planteamiento analítico para la obtención de las deformaciones y solicitaciones en tableros con vigas gemelas, en especial los obtenidos a partir de secciones prefabricadas en artesa. Fue de inspiración y fundamento, la fuerza de la descomposición de la función resistente en estados más simples, para la obtención de una formulación matemática. Se trata de una forma similar al planteamiento que realizó Javier Manterola en el memorable articulo “La sección abierta y cerrada bajo solicitación excéntrica” [1]. Para la resolución se efectuará una aproximación al formalismo matemático de las funciones de Green. El planteamiento requiere una serie de simplificaciones admisibles que aproximan con bastante rigor la solución, y permiten la evaluación directa de la acción de cargas móviles. Por último, se efectúa un análisis de la efectividad del reparto transversal conseguido con diversas condiciones de apoyo.
Using the Height-for-Age Z-score (HAZ) to predict protein-energy malnutrition in patients with congenital epidermolysis bullosa through the application of machine learning methods
Authors: Orlova O. S. 
Published: July 2024

Congenital epidermolysis bullosa (СЕВ) is a group of genetically and clinically heterogeneous diseases characterized by a tendency to form blisters and/or erosions on the skin and mucous membranes with minimal trauma. Nutritional deficiency stands as the most common complication observed in EB, with its development influenced by a multitude of contributing factors.Purpose of the study. To construct a predictive model for the development of protein-energy malnutrition in patients with various forms of EB, identify the main features affecting the sensitivity of the predictive model, and evaluate the model’s validity based on retrospective data on the presence of protein-energy malnutrition in this patient category.Methods. The study involved 101 patients aged 3 to 18 years with simplex (n=25), junctional (n=10), and dystrophic (n=66) СEB. The Birmingham EB Severity Score, laboratory and anthropometric parameters, as well as data on the presence of gastrointestinal complications, were used for the analysis of disease progression and predictive model construction. The Scikit-learn library of the programming language Python was utilized for building the machine learning model.Results. In the construction of the predictive model, the RandomForestClassifier model showed the best results. The developed machine learning model can correctly determine whether a patient has chronic protein-energy malnutrition (class 1, HAZ < –2) or not (class 0, HAZ > –2) with an accuracy of 92%, sensitivity of 85.7%, and specificity of 100%.Conclusions. The machine learning model presented in this study predicts the values of the Height-for-Age Z-score (HAZ) and can have practical significance in medical practice and clinical research. The model can be used for early diagnosis of protein-energy malnutrition in patients with EB, which may allow healthcare professionals to timely start nutritional support and prevent possible complications of the disease, as well as develop individual nutrition and treatment plans for patients.
STUDENTS’ SATISFACTION OF LECTURER TEACHING PERFORMANCE ONLINE AT INSTITUTE OF HOME AFFAIR GOVERNANCE (IPDN)
Authors: Maisondra Maisondra 
Published: July 2024

The implementation of online learning during the Covid-19 Pandemic is a government policy in order to reduce the spread of the disease outbreak. It is not yet known to what extent it reduces the teaching performance of lecturers. This study to determine IPDN students’ satisfaction of lecturer performance in teaching online which was carried out, which was seen through four indicators, namely: 1) Teaching Preparation, 2) Discipline, 3) Interaction, and 4) Evaluation. This type of research is descriptive analysis research, which is an attempt to describe the performance of lecturers in teaching online. Data were obtained from the results of field research by distributing questionnaires in the form of asking questions directly to 160 respondents (or 10 percent of the total, 1,600 junior students) who had previously been randomly selected from junior students of IPDN. The data obtained were analyzed using qualitative analysis methods. The results showed that: Assessment for Teaching Preparation 95.5 percent, Discipline 90 percent, Interaction 80 percent, and Evaluation 94.5 percent. If we take the average score given by junior students or the satisfaction level is: 90 percent. This figure is quite high. But, the bias of this study is that the tendency of students' evaluation of lecturer performance is always to say that it is very good and good close to 100 percent. These figures do not yet show what percentage actually teaching online during the Covid-19 pandemic has reduced lecturer performance compared to teaching offline. This figure only shows the level of student satisfaction level with lecturer performance in teaching based on the four indicators above.
PERAN SUMBER DAYA MANUSIA KEPALA DESA YANG BERKUALITAS DALAM CAPAIAN INDEKS DESA MEMBANGUN
Authors: MUHI ALI HANAFIAH 
Published: July 2024

Pemerintah dan pemerintah daerah berusaha keras untuk mensejahterakan masyarakat, termasuk masyarakat desa. Khusus bagi desa, upaya itu dilakukan melalui kegiatan menggerakkan dan membangun desa. Agar pembangunan desa lebih terarah, Kemendes PDTT menetapkan metode dan alat ukurnya, yaitu Indeks Desa Membangun (IDM). Namun dalam pelaksanaannya pembangunan desa masih menghadapi berbagai permasalahan, diantaranya keterbatasan sumber daya manusia (SDM) yang berkualitas. Secara nasional, Kepala Desa berpendidikan SMA ke bawah masih sangat dominan mencapai 74,55 persen. Hal ini juga dihadapi oleh Provinsi Jawa Barat, yang merupakan Provinsi penyangga ibukota Negara Republik Indonesia DKI Jakarta.
Metode penelitian yang digunakan adalah metode penelitian kuantitatif. Sumber data diperoleh dari studi dokumentasi dan libraries studies. Data diolah, dan dianalisis dengan uji statistik sederhana. Selanjutnya, melakukan penafsiran hasil analisis, dan pembahasan, serta penarikan kesimpulan.
Hasil penelitian menunjukkan bahwa sampai tahun 2023 tingkat pendidikan Kepala Desa di Provinsi Jawa Barat lebih baik dibanding Nasional. Capaian IDM di Provinsi Jawa Barat lebih baik dibanding Nasional. Provinsi Jawa Barat telah berhasil keluar dari belenggu Desa Sangat Tertinggal dan Desa Tertinggal, sedangkan Nasional belum. Kondisi ini erat kaitannya dengan kualitas SDM (Kepala Desa). Perbandingan persentase Kepala Desa berpendidikan tinggi di Jawa Barat dan Nasional adalah 33,68 persen berbanding 25,45 persen, sedangkan untuk yang berpendidikan SMA ke bawah adalah 66,32 persen berbanding 74,55 persen. Kondisi ini berpengaruh terhadap kontribusi Kepala Desa dalam capaian IDM. Hal ini dapat dilihat dari laju pertumbuhan capaian IDM di Provinsi Jawa Barat sebesar 0,028 lebih besar daripada laju capaian IDM Nasional sebesar 0,017. Laju pertumbuhan capaian IDM di Provinsi Jawa Barat hampir 2 (dua) kali lipat dari laju pertumbuhan capaian IDM Nasional. Ini membuktikan bahwa kualitas SDM atau Kepala Desa yang berpendidikan lebih baik (tinggi) mampu memberikan kontribusi nyata dalam laju pertumbuhan IDM. Semakin tinggi tingkat pendidikan Kepala Desa, maka semakin tinggi laju pertumbuhan IDM. Artinya, semakin tinggi tingkat pendidikan Kepala Desa, semakin besar kontribusi atau perannya dalam pembangunan dan kemajuan desa.
Assessment of the therapeutic potential of Hsp70 activator against prion diseases using in vitro and in vivo models
Authors: Zayed Mohammed , Kim Yong-Chan , Jeong Byung-Hoon 
Published: July 2024

IntroductionPrion diseases are deadly neurodegenerative disorders in both animals and humans, causing the destruction of neural tissue and inducing behavioral manifestations. Heat shock proteins (Hsps), act as molecular chaperones by supporting the appropriate folding of proteins and eliminating the misfolded proteins as well as playing a vital role in cell signaling transduction, cell cycle, and apoptosis control. SW02 is a potent activator of Hsp 70 kDa (Hsp70).MethodsIn the current study, the protective effects of SW02 against prion protein 106-126 (PrP106-126)-induced neurotoxicity in human neuroblastoma cells (SH-SY5Y) were investigated. In addition, the therapeutic effects of SW02 in ME7 scrapie-infected mice were evaluated.ResultsThe results showed that SW02 treatment significantly increased Hsp70 mRNA expression levels and Hsp70 ATPase activity (p &lt; 0.01). SW02 also significantly inhibited cytotoxicity and apoptosis induced by PrP106-126 (p &lt; 0.01) and promoted neurite extension. In vivo, intraperitoneal administration of SW02 did not show a statistically significant difference in survival time (p = 0.16); however, the SW02-treated group exhibited a longer survival time of 223.6 ± 6.0 days compared with the untreated control group survival time of 217.6 ± 5.4 days. In addition, SW02 reduced the PrPSc accumulation in ME7 scrapie-infected mice at 5 months post-injection (p &lt; 0.05). A significant difference was not observed in GFAP expression, an astrocyte marker, between the treated and untreated groups.ConclusionIn conclusion, the potential therapeutic role of the Hsp70 activator SW02 was determined in the present study and may be a novel and effective drug to mitigate the pathologies of prion diseases and other neurodegenerative diseases. Further studies using a combination of two pharmacological activators of Hsp70 are required to maximize the effectiveness of each intervention.
Advancements in reperfusion rates and quality of care for ST-segment elevation myocardial infarction: a ten-year evaluation of Salvador's STEMI network
Authors: Roriz Pollianna Souza , Ferreira Isabella Bonifácio Brige , Pontes Fabiana Benevides , Machado Antônio , Aguiar Tércio Caires , Matos Marcos Antônio Almeida , Paiva Filho Ivan Mattos , Menezes Rodrigo Carvalho , Andrade Bruno Bezerril 
Published: July 2024

BackgroundContinuous investment and systematic evaluation of program accomplishments are required to achieve excellence in ST-segment elevation myocardial infarction (STEMI) care, especially in resource-limited settings. Therefore, this study evaluates the impact of problem-driven interventions on reperfusion use rate in a long-term operating STEMI network from a low- to middle-income country.MethodsThis is a healthcare improvement evaluation study of Salvador's public STEMI network in a quasi-experimental design, comparing data from 2009 to 2010 (pre-intervention) and 2019-2020 (post-intervention). There were evaluated all confirmed STEMI cases assisted in both periods. The interventions, implemented since 2017, included: expanding the support team, defining criteria to be a spoke, and initiating continuous education activities. The primary outcome was the rate of patients undergoing reperfusion, with secondary outcomes being time from door-to-ECG (D2E) and ECG-to-STEMI-team trigger (E2T).ResultsOver ten years, the network's coverage increased by 300,000 individuals, and expanded by 1,800 km2. A total of 885 records were analyzed, 287 in the pre-intervention group (182 men [63·4%]; mean [SD] age 62·1 [12·5] years) and 598 in the post-intervention group (356 men [59·5%]; mean [SD] age 61.9 [11·8] years). It was noticed a substantial increase in reperfusion delivery rate (90 [31%] vs. 431 [73%]; P = 001) and reductions in time from D2E (159 [83–340] vs. 29 [15–63], P = 001), and E2T (31 [21–44] vs. 16 [6–40], P = 001).ConclusionThe strategies adopted by Salvador's STEMI network were associated with significant improvements in the rate of patients undergoing reperfusion and in D2E and E2T. However, the mortality rate remains high.
Identification of signature genes and immune infiltration analysis in thyroid cancer based on PANoptosis related genes
Authors: Li Yujie , Wu Dengqiang 
Published: July 2024

BackgroundThyroid cancer is the most common malignancy of the endocrine system. PANoptosis is a specific form of inflammatory cell death. It mainly includes pyroptosis, apoptosis and necrotic apoptosis. There is increasing evidence that PANoptosis plays a crucial role in tumour development. However, no pathogenic mechanism associated with PANoptosis in thyroid cancer has been identified.MethodsBased on the currently identified PANoptosis genes, a dataset of thyroid cancer patients from the GEO database was analysed. To screen the common differentially expressed genes of thyroid cancer and PANoptosis. To analyse the functional characteristics of PANoptosis-related genes (PRGs) and screen key expression pathways. The prognostic model was established by LASSO regression and key genes were identified. The association between hub genes and immune cells was evaluated based on the CIBERSORT algorithm. Predictive models were validated by validation datasets, immunohistochemistry as well as drug-gene interactions were explored.ResultsThe results showed that eight key genes (NUAK2, TNFRSF10B, TNFRSF10C, TNFRSF12A, UNC5B, and PMAIP1) exhibited good diagnostic performance in differentiating between thyroid cancer patients and controls. These key genes were associated with macrophages, CD4+ T cells and neutrophils. In addition, PRGs were mainly enriched in the immunomodulatory pathway and TNF signalling pathway. The predictive performance of the model was confirmed in the validation dataset. The DGIdb database reveals 36 potential therapeutic target drugs for thyroid cancer.ConclusionOur study suggests that PANoptosis may be involved in immune dysregulation in thyroid cancer by regulating macrophages, CD4+ T cells and activated T and B cells and TNF signalling pathways. This study suggests potential targets and mechanisms for thyroid cancer development.
Case report: Comprehensive follow-up of a Colombian family carrying a novel MEN1 variant linked to a rare ACTH-producing pancreatic neuroendocrine carcinoma
Authors: Riaño-Moreno Julián C. , González-Clavijo Angélica María , Torres J. William C. , Medina B. Vilma L. , Romero-Rojas Alfredo Ernesto , Vieda-Celemin Isabella , Avila-Moya Jordan A. , Baron-Cardona Johan A. , Bravo-Patiño Juan P. , Torres-Zambrano Oscar S. , Maya Luis Felipe Fierro 
Published: July 2024

BackgroundMultiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disorder marked by pathogenic variants in the MEN1 tumor suppressor gene, leading to tumors in the parathyroid glands, pancreas, and pituitary. The occurrence of ACTH-producing pancreatic neuroendocrine carcinoma is exceedingly rare in MEN1.Case presentationThis report details a Colombian family harboring a novel MEN1 variant identified through genetic screening initiated by the index case. Affected family members exhibited primary hyperparathyroidism (PHPT) symptoms from their 20s to 50s. Uniquely, the index case developed an ACTH-secreting pancreatic neuroendocrine carcinoma, a rarity in MEN1 syndromes. Proactive screening enabled the early detection of pituitary neuroendocrine tumors (PitNETs) as microadenomas in two carriers, with subsequent surgical or pharmacological intervention based on the clinical presentation.ConclusionOur findings underscore the significance of cascade screening in facilitating the early diagnosis and individualized treatment of MEN1, contributing to better patient outcomes. Additionally, this study brings to light a novel presentation of ACTH-producing pancreatic neuroendocrine carcinoma within the MEN1 spectrum, expanding our understanding of the disease’s manifestations.
The effect of Chinese herbal medicine on male factor infertility: study protocol for a randomized controlled trial
Authors: Wen Qidan , Xu Huanying , Zou Haoxi , Wang Pei , Xing Xiaoyan , Chen Ying , Zhu Qiaoling , Chen Yu , Tan Minhua , Zhang Miaomiao , Pan Ting , Chen Yanfen , Wang Yingju , Wu Suzhen 
Published: July 2024

BackgroundThe global prevalence of infertility is 9%, with male factors potentially accounting for 40% to 60% of cases. Conventional treatments can be ineffective, invasive, costly, and linked to adverse effects and high risks. Previous studies have shown that, Chinese herbal medicine (CHM) can regulate the hypothalamus-pituitary-testis axis, improve sperm abnormalities and quality, mitigate oxidative stress, and decrease DNA fragmentation index (DFI). Yet, the evidence backing the use of Chinese herbal medicine (CHM) for treating male factor infertility lacks conviction due to study design limitations, and there remains a scarcity of studies on the live birth rate following CHM treatment for male factor infertility. Here, we describe the rationale and design of a randomized waitlist-controlled trial to evaluate the effect of CHM on the live birth rate among males with infertility.MethodsThis study is a single-center, randomized, waitlist-controlled study. A total of 250 couples diagnosed with male factor infertility will be enrolled in this study and then randomly allocated into two groups in a 1:1 ratio. Male participants in CHM group (treatment group) will receive CHM once a day for 3 months. Male participants in the waitlist group (control group) will not receive any treatment for 3 months. After 3 months, participants in both groups need to be followed up for another 12 months. The primary outcome will be the live birth rate; secondary outcomes include semen quality parameters, DFI and pregnancy related outcomes. Safety will also be assessed.DiscussionThe purpose of this trial is to explore the effects and safety of CHM on the live birth rate among couples dealing with male factor infertility. The outcome of this trial may provide a viable treatment option for male factor infertility.Trial registrationChinese Clinical Trial Registry: ChiCTR2200064416. Registered on 7 October 2022, https://www.chictr.org.cn.
Benefits of controlled-release fertilizers for potato sustainable nitrogen management
Authors: Xue Huiling , Zheng Xiaofan , Wei Hong , Yang Jing , Alva Ashok , Fan Mingshou , Zhang Ziyi 
Published: July 2024

The evaluation of potato response to controlled-release fertilizers (CRFs), as a sole source of nitrogen (N) or as a blend with a soluble N source, is essential to 1) develop the best management recommendations for using CRFs in potato production and 2) provide guidelines to CRF manufacturers for developing an optimal product. This study aimed to evaluate the potato yield and quality responses to N CRFs (polymer-coated urea [PCU]) vs soluble N sources. The experiments were conducted in major potato-growing regions in the United States and China. The current industry-recommended practice of 112 kg N/ha pre-plant soil broadcast of urea plus five in-season fertigations of 224 kg N/ha as urea ammonium nitrate (UAN-32) was compared to a single pre-plant application of 224 kg N/ha as a CRF as the sole source of N or as multiple blends of CRFs and soluble N sources (i.e., urea) at various ratios. The results demonstrated that petiole nitrate_N (NO3_N) levels and tuber yield with single pre-plant broadcast applications of 224 kg N/ha as CRF/urea blends (ratio of 25/75 or 50/50) were similar to those obtained with industry-standard N management practice. N uptake and yield were significantly greater with 220 kg/ha N as the CRF than those with the same N rate as urea. Unlike the current potato industry N practice, using CRFs as either a sole source of N or blended with urea reduces the total N rate and application frequency.
Sjögren’s syndrome and Parkinson’s disease: a bidirectional Mendelian randomization study
Authors: Yin Xi , Wang Miao , Li Fengzhu , Wang Zhenfu , Gao Zhongbao 
Published: July 2024

BackgroundPrevious epidemiological studies have reported an association between Sjögren’s syndrome (SS) and Parkinson’s disease (PD); however, the causality and direction of this relationship remain unclear. In this study, we aimed to investigate the causal relationship between genetically determined SS and the risk of PD using bidirectional Mendelian randomization (MR).MethodsSummary statistics for Sjögren’s syndrome used as exposure were obtained from the FinnGen database, comprising 1,290 cases and 213,145 controls. The outcome dataset for PD was derived from the United Kingdom Biobank database, including 6,998 cases and 415,466 controls. Various MR methods, such as inverse variance weighted (IVW), Mendelian randomization Egger regression (MR-Egger), weighted median (WM), simple mode, weighted mode, MR-pleiotropy residual sum and outlier (MR-PRESSO), and robust adjusted profile score (RAPS), were employed to investigate the causal effects of SS on PD. Instrumental variable strength evaluation and sensitivity analyses were conducted to ensure the reliability of the results. In addition, reverse MR analysis was performed to examine the causal effects of PD on SS.ResultsThe WM, IVW, RAPS and MR-PRESSO methods demonstrated a significant association between genetically predicted SS and reduced risk of PD (odds ratio ORWM = 0.9988, ORIVW = 0.9987, ORRAPS = 0.9987, ORMR-PRESSO = 0.9987, respectively, P &lt; 0.05). None of the MR analyses showed evidence of horizontal pleiotropy (P &gt; 0.05) based on the MR-Egger and MR-PRESSO tests, and there was no statistical heterogeneity in the test results of the MR-Egger and IVW methods. The leave-one-out sensitivity analysis confirmed the robustness of the causal relationship between SS and PD. Furthermore, reverse MR analysis did not support any causal effects of PD on SS.ConclusionOur MR study supports a potential causal association between SS and a reduced risk of PD. Further extensive clinical investigations and comprehensive fundamental research are warranted to elucidate the underlying mechanisms linking SS and PD.
Disparities in burden of herpes simplex virus type 2 in China: systematic review, meta-analyses, and meta-regressions
Authors: Wang Yehua , Yan Xumeng , Ai Wei , Jia Yuanxi , Fan Chengxin , Hu Siyue , Dai Yifan , Xue Huachen , Li Feifei , Tang Weiming 
Published: July 2024

BackgroundThe rising prevalence of herpes simplex type 2 (HSV-2) infection poses a growing global public health challenge. A comprehensive understanding of its epidemiology and burden disparities in China is crucial for informing targeted and effective intervention strategies in the future.MethodsWe followed Cochrane and PRISMA guidelines for a systematic review and included publications published in Chinese and English bibliographic systems until March 31st, 2024. We synthesized HSV-2 seroprevalence data across different population types. We used random-effects models for meta-analyses and conducted meta-regression to assess the association between population characteristics and seroprevalence.ResultsOverall, 23,999 articles were identified, and 402 publications (1,203,362 participants) that reported the overall seroprevalence rates (858 stratified measures) were included. Pooled HSV-2 seroprevalence among the general population (lower risk) was 7.7% (95% CI: 6.8-8.7%). Compared to the general population, there is a higher risk of HSV-2 prevalence among intermediate-risk populations (14.8%, 95% CI: 11.0-19.1%), and key populations (31.7%, 95% CI: 27.4-36.1%). Female sexual workers (FSWs) have the highest HSV-2 risk (ARR:1.69, 95% CI: 1.61-1.78). We found northeastern regions had a higher HSV-2 seroprevalence than other regions (17.0%, 95% CI: 4.3-35.6%, ARR: 1.38, 95% CI: 1.26-1.50, Northern China as the reference group). This highlighted the disparity by population risk levels and regions. We also found lower HSV-2 prevalence estimates in publications in Chinese bibliographic databases than those in English databases among key populations (such as MSM and HIV-discordant populations).ConclusionThere is a gradient increase in HSV-2 prevalence risk stratification. We also identified region, population, and age disparities and heterogeneities by publication language in the HSV-2 burden. This study provides guidance for future HSV-2 prevention to eliminate disparities of HSV-2 infection and reduce overall HSV-2 burden.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=408108, identifier CRD42023408108.