bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of continuous nursing on treatment compliance and side effect management of coronary heart disease
Authors: Wei Juan , Li Bai-Wen-Xian , Han Shao-Jie , Zhuang Hong-Jie , Cao Wen-Hong 
Published: June 2024

BACKGROUND
There are relatively few studies on continuing care of coronary heart disease (CHD), and its research value needs to be further clarified.
AIM
To investigate the effect of continuous nursing on treatment compliance and side effect management in patients with CHD.
METHODS
This is a retrospective study with patients from January 2021 to 2023. The study was divided into two groups with 30 participants in each group. Self-rating anxiety scale (SAS) and Self-rating depression scale (SDS) were used to assess patients' anxiety and depression, and medical coping questionnaire was used to assess patients' coping styles. The pelvic floor dysfunction questionnaire (PFDI-20) was used to assess the status of pelvic floor function, including bladder symptoms, intestinal symptoms, and pelvic symptoms.
RESULTS
SAS score decreased from 57.33 ± 3.01before treatment to 41.33 ± 3.42 after treatment, SDS score decreased from 50.40 ± 1.45 to 39.47 ± 1.57. The decrease of these two indexes was statistically significant (P < 0.05). PFDI-20 scores decreased from the mean 16.83 ± 1.72 before treatment to 10.47 ± 1.3the mean after treatment, which was statistically significant (P < 0.05).
CONCLUSION
The results of this study indicate that pioneering research in continuous care of CHD has a positive impact on improving patients' treatment compliance, reducing anxiety and depression levels, and improving coping styles and pelvic floor functional status.
Application of multidisciplinary team-based integrated traditional Chinese medicine and Western medicine in rotator cuff injury patients undergoing arthroscopic surgery
Authors: Cao Di-Ping , Yin Lei , Wang Yi-Fei , Liu Bing-Li 
Published: June 2024

BACKGROUND
Arthroscopic rotator cuff repair is a common surgical treatment for rotator cuff injuries (RCIs). Although this procedure has certain clinical advantages, it requires rehabilitation management interventions to ensure therapeutic efficacy.
AIM
To investigate the effect of integrated traditional Chinese medicine and Western medicine (TCM-WM) under the multidisciplinary team (MDT) model on the postoperative recovery of patients undergoing arthroscopic surgery for RCIs.
METHODS
This study enrolled 100 patients who underwent arthroscopic rotator cuff repair for RCIs at the Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine between June 2021 and May 2024. They were divided into a control group (n = 48) that received routine rehabilitation treatment and an experimental group (n = 52) that received TCM-WM under the MDT model (e.g. , acupuncture, TCM traumatology and orthopedics, and rehabilitation). The results of the Constant–Murley Shoulder Score (CMS), Visual Analogue Scale (VAS), Shoulder Pain and Disability Index (SPADI), muscular strength evaluation, and shoulder range of motion (ROM) assessments were analyzed.
RESULTS
After treatment, the experimental group showed significantly higher CMS scores in terms of pain, functional activity, shoulder joint mobility, and muscular strength than the baseline and those of the control group. The experimental group also exhibited significantly lower VAS and SPADI scores than the baseline and those of the control group. In addition, the experimental group showed significantly enhanced muscular strength (forward flexor and external and internal rotator muscles) and shoulder ROM (forward flexion, abduction, and lateral abduction) after treatment compared with the control group.
CONCLUSION
TCM-WM under the MDT model improved shoulder joint function, relieved postoperative pain, promoted postoperative functional recovery, and facilitated the recovery of muscular strength and shoulder ROM in patients with RCIs who underwent arthroscopic rotator cuff repair.
Prognostic role of the stromal cell derived factor-1 in patients with hepatitis B virus-related acute-on-chronic liver failure
Authors: Zhang Li , Wang Jian-Yu , Zhao Cai-Yan , Shen Chuan , Chen Mei-Ru , Tian Zhi-Ying 
Published: June 2024

BACKGROUND
Stromal cell derived factor-1 (SDF-1) plays a pivotal role in the recruitment of stem cells to injured livers. However, the changes of SDF-l in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) have yet to be elucidated.
AIM
To study the SDF-1 changes in patients with HBV-related ACLF.
METHODS
30 patients with HBV-related ACLF, 27 patients with chronic hepatitis B and 20 healthy individuals are involved in our study. The SDF-l mRNA expression in liver tissue was detected by quantitative real-time polymerase chain reaction. Immunohistochemical staining was performed to illustrate the expression of SDF-l, CXC receptor 4 (CXCR4) and Ki67. The serum SDF-l concentrations were also detected by enzyme-linked immunosorbent assays.
RESULTS
The expression of SDF-1 mRNA from ACLF patients was remarkably higher than that from other patients (both P < 0.05). The expression of SDF-l, CXCR4 and Ki67 from ACLF were the highest among the three groups (all P < 0.01). The serum SDF-l levels in ACLF patients were significantly lower than that in other patients (both P < 0.01). Moreover, in ACLF patients, the serum SDF-1 Levels were positively correlated with serum total bilirubin and international normalized ratio. In addition, the serum SDF-l levels in survival were significantly lower compared with the non-survivals (P < 0.05). The area under the curve for the serum SDF-1 level in predicting 28-d mortality was 0.722 (P < 0.05).
CONCLUSION
This study provides the SDF-1 changes in patients with HBV-related ACLF. The SDF-1 Level at admission may serve as a promising prognostic marker for predicting short-term prognosis.
Efficacy of fexuprazan compared with rebamipide in Korean patients with gastritis: A matching-adjusted indirect comparison
Authors: Kim Gwang Ha , Lee Hang Lak 
Published: June 2024

BACKGROUND
Gastritis is one of the most frequently diagnosed diseases requiring medical treatment in South Korea. Fexuprazan, a novel potassium-competitive acid blocker, has been approved for treating gastritis and erosive esophagitis. Meanwhile, rebamipide is the most commonly used mucoprotective agent for acute and chronic gastritis in real-world settings in South Korea. However, there have been no studies comparing the efficacy of these two drugs yet.
AIM
To compare the efficacy of fexuprazan with that of rebamipide for acute and chronic gastritis.
METHODS
This was a matching-adjusted indirect comparison. Individual patient data from a phase III study of fexuprazan (10 mg BID) were compared with cumulative data from two matching studies of rebamipide (100 mg TID). Erosion improvement and healing rates were compared between two weeks of fexurapan, two weeks of rebamipide, and four weeks of rebamipide. The two main outcome variables were presented as percentages, and the risk differences (RD) and 95% confidence intervals (CI) were calculated for the relative treatment effects.
RESULTS
In the primary analysis, the erosion improvement and healing rates after a two-week treatment with fexuprazan were 64.5% and 53.2%, respectively, while a two-week treatment with rebamipide resulted in erosion improvement and healing rates of 43.6% (RD: 21.0%; 95%CI: 9.6-32.3; P < 0.01) and 35.6% (RD: 17.6%; 95%CI: 6.1-29.2; P = 0.003), respectively. In the additional analysis, the erosion improvement and healing rates for the two-week fexuprazan treatment (64.2% and 51.2%, respectively) were similar to those obtained during a four-week treatment with rebamipide (60.6%; RD: 3.6%; 95%CI: -9.8, 17.0; P = 0.600 and 53.5%; RD: -2.3%; 95%CI: -16.1, 11.5; P = 0.744, respectively).
CONCLUSION
The two-week fexuprazan treatment was superior to the two-week rebamipide treatment and similar to the four-week rebamipide treatment for patients with gastritis.
Renal anastomosing hemangioma following partial nephrectomy for renal cell carcinoma: A case report
Authors: Chen Juan , Cai Di-Ming 
Published: June 2024

BACKGROUND
Renal anastomosing hemangioma (AH) is a rare benign vascular tumor characterized by unique histopathological features.
CASE SUMMARY
We report a highly unusual case of renal AH. A male patient had undergone partial nephrectomy for clear cell carcinoma of the kidney four years prior. A follow-up computed tomography scan in the third postoperative year revealed a new mass near the surgical site on the same side of the kidney, raising suspicions of tumor recurrence. However, the characteristics on contrast-enhanced magnetic resonance imaging and ultrasonography were more consistent with those of a benign lesion. The patient strongly insisted on undergoing surgery due to concerns about the possibility of renal cancer recurrence. Postoperative pathology confirmed the diagnosis of renal AH.
CONCLUSION
This case report presents the imaging features of a patient with rare renal AH and a history of renal clear cell carcinoma, providing broader insights into the differential diagnosis of new lesions after surgery for renal cell carcinoma.
Validation of the COmprehensive Score for Financial Toxicity (COST) in Vietnamese patients with cancer
Authors: Tran Binh Thang , Le Dinh Duong , Nguyen Thanh Gia , Nguyen Minh Tu , Nguyen Minh Hanh , Dang Cao Khoa , Tran Dinh Trung 
Published: June 2024

Introduction
The COmprehensive Score for Financial Toxicity (COST) has proven to be a reliable tool for quantifying the impact of financial toxicity (FT) in patients with cancer in clinical and public health settings. However, the COST has not yet been validated in Vietnam. Therefore, we aimed to evaluate its reliability and validity among Vietnamese patients with cancer.

Methods
A cross-sectional study was conducted in a sample of 300 patients with cancer aged 27–95 years (mean: 58.5±11.2) in a tertiary hospital. The COST was translated into Vietnamese and English and adjusted to suit the local culture. Reliability was evaluated using Cronbach’s alpha and McDonald’s omega coefficients. The construct and convergent validities were also assessed.

Results
The COST demonstrated good internal consistency and reliability (Cronbach’s alpha = 0.913; McDonald’s omega = 0.915). The exploratory factor analysis revealed two factors that explained 64.9% of the variance. The adjusted fit indices indicated a good fit of the model (χ2 (39) = 67.78, p = 0.003; standardized root mean squared residual = 0.042; Tucker–Lewis index = 0.971; comparative fit index = 0.979; root mean square error of approximation = 0.061, 90% confidence interval = 0.035–0084). Higher COST scores were significantly correlated with higher health-related quality of life (EQ-5D-5L utility score: r = 0.21, p = 0.002; EQ VAS: r = 0.28, p < 0.001). Multivariate quantile regression analysis revealed that female sex, rural residence, and unstable job/unemployment were associated with lower COST scores. There was no statistically significant difference in other factors, including clinical factors (types of cancer, staging, and treatment modalities).

Conclusions
The COST is reliable and valid, making it suitable for assessing FT severity in Vietnamese patients with cancer.
Sustainable Theatre: Theory, Context, Practice, Iphigenia Taxopoulou (2023)
Authors: Richards Kimberly Skye 
Published: June 2024

Review of: Sustainable Theatre: Theory, Context, Practice, Iphigenia Taxopoulou (2023)
London: Methuen Drama, 256 pp.,
ISBN 978-1-35021-572-6, h/bk, £22.49
Student-Teacher Alliance Buffers Against the Impact of Moderate Math Anxiety on Course Performance among College Students
Authors: Palmwood Erin 
Published: June 2024

Students with math anxiety experience low self-efficacy and high levels of distress when asked to approach math tasks and concepts, which often results in poor course performance. Despite the wealth of research on this construct, relatively little is known about how math anxiety impacts math achievement in college-aged students or what types of classroom-based processes might buffer against this harmful effect. The present study therefore examined the student-teacher alliance as a potential buffer against the detrimental effect of math anxiety on course grades in a sample of non-STEM college students enrolled in a required mathematics course. Students completed questionnaires regarding their math anxiety, overall anxiety, perception of their alliance with their course instructor, and class grade over the course of a semester. Results indicated that, although elevated math anxiety was associated with poorer course performance, this link was weakened for students who perceived themselves to have a stronger relationship with their instructor. However, this moderation effect was present for students with low to moderate, but not high, math anxiety. Findings highlight the importance of college-level math instructors attending to the student-teacher alliance as a potential anxiety mitigation strategy, particularly for students with moderate levels of math anxiety.
Biological engineering as a driver of innovation: implications for the economy
Authors: Dang Vo To Nguyen , Bock Carolin , Linn Norbert 
Published: June 2024

Abstract
The world economy’s growth has devastated the environment, risking resource scarcity. Recognizing the urgency, various business concepts aim for triple bottom line goals – ecological, economic, and social. Biological engineering emerges as a promising solution, utilizing renewable biological resources to address global challenges. This paper explores its role across sectors like novel materials and agriculture, shifting focus to economic implications, especially in startup ventures. By examining global startups’ distribution and venture capital investments, it highlights their role in driving innovation and economic growth. It underscores biological engineering’s potential in addressing environmental challenges and fostering prosperity through innovative startups, bridging science and business for sustainability.
Advancing vertical farming with automation for sustainable food production
Authors: Asseng Senthold , Eichelsbacher Sebastian 
Published: June 2024

Abstract
The increasing global population, combined with the impacts of climate change, underscores the urgent need for novel food production systems. Conventional field-based agriculture strains planetary boundaries. Vertical farming (VF) emerges as a promising alternative. It enables precise manipulation of growth factors, including light, temperature, humidity, and nutrient delivery, leading to higher yields and superior crop quality while reducing the environmental impact. Automation and robotics will enhance efficiency, while hydroponic techniques minimize fertilizer usage. Collaborative efforts are essential to address challenges such as energy consumption and technology costs to fully realize the potential of VF. Vertical farming aligns with many of the Global Sustainability Goals, offering a pathway towards food security challenges while fostering sustainability.
Harnessing microalgae: from biology to innovation in sustainable solutions
Authors: Greulich Simon , Tran Nam Trung , Kaldenhoff Ralf 
Published: June 2024

Abstract
Microalgae, small single or multicellular photosynthetic active organisms, could be a component to solve our urgent global challenges. This review provides a concise introduction to biology and applications of microalgae. On an example from our own scientific studies, we illustrate how these organisms could replace respectively optimize carbon producing processes. We will also describe the potential of microalgae for sustainable production towards atmospheric CO2 sequestration. Development of machine learning techniques forecast a paradigm shift regarding scientific methods. It concerns synthetic biology as well as engineering of metabolism in microalgae.
Evolution of biofabrication and 3D-bioprinting technologies – from market pull to technology push
Authors: Blaeser Andreas 
Published: June 2024

Abstract
Biofabrication is a biomedical key technology for the cultivation of living tissue structures. Here, living cells are embedded in a hydrogel matrix and joined using various processes (e.g. 3D-bioprinting) to form a multicellular construct. The so formed tissue precursor then undergoes a growth process lasting several weeks in bioreactors in order to mature into living tissue. The development of today’s biofabrication processes was originally motivated by clinical needs in the field of regenerative medicine. In this context, the focus is on the cultivation of tissue or organ parts for the regeneration of affected patients. Due to the increasing maturity of the technology and its excellent scaling potential, the range of applications has expanded to other markets, such as the pharmaceutical, cosmetics and chemical industries (e.g. in-vitro tissue models) or the field of cellular agriculture (e.g. cultured meat). Engineered living materials represent another particularly new and fast-growing field of application. The following article shows how the technology has developed from the demands of regenerative medicine (market pull) and is now pushing into completely new markets on this basis (technology push). It provides an comprehensive overview of the development of the technology and the wide range of its current fields of application.
Protean Matter-Shifting: A Clarification of the Evolving Relation Between Schellingian Materie and Neoplatonic ὕλη
Authors: Barton Jason 
Published: June 2024

Abstract
The established scholarly perspective on the relationship between F.W.J. Schelling’s Naturphilosophie and Neoplatonic metaphysics is underdeveloped. This perspective asserts that Schelling consistently distances himself from the emanation-based framework of Neoplatonism along with its construction of matter (ὕλη) as completely passive, purely potential, and spectrally obscure. Such a hermeneutic emerges from a close reading of Schelling’s 1794 Timaeus commentary as well as his 1811–1815 Weltalter drafts. I mark my intervention at the temporal midpoint of this range (1804–1806), namely during the final throes of Schelling’s Identitätsphilosophie. At this point in Schelling’s intellectual itinerary, he discloses a proximity between his conceptual configuration of matter (die Materie) and the aforementioned, Neoplatonic conceptual configuration of matter. Insofar as heretofore erudition has overlooked the denouement of Schelling’s early philosophical phase, it has also neglected Schelling’s coquettish attitude toward Neoplatonism and its ontological destitution of matter. I intend to highlight the overlap between these respective approaches.
Molecular analysis reveals the evolutionary distinctiveness of the Silver-backed Chevrotain within the genus Tragulus
Authors: Nguyen Tham Thi , Hoang Huy Quoc , Ho Anh Thi Ngoc , Nguyen Trung Thanh , Trinh Ha Thi Le , Nguyen Mai Thi Phuong , Nguyen Tao Thien , Le Minh Duc 
Published: June 2024

Abstract
The Silver-backed Chevrotain (Tragulus versicolor), a mammal endemic to the unique coastal arid ecosystem in south-central Vietnam, is an enigmatic mouse deer with little information available about its ecology and evolutionary history. The recent rediscovery of the species provides a rare opportunity to clarify its taxonomy and phylogenetic relationship within the genus Tragulus. In this study, we sequenced the complete mitochondrial cytochrome b gene for samples of T. versicolor and T. kanchil from Vietnam. Our molecular results show that the species forms a distinct evolutionary lineage sister to all other species in the genus, confirming the earlier hypothesis based on morphological evidence. However, further research is needed to assess the genetic diversity of the species and design appropriate conservation measures. As the species has not been secured over much of its range, it is recommended that the population in Nui Chua National Park, the only one covered by a protected area, be prioritized for conservation actions. Conserving the species in this unique and imperiled ecosystem will also benefits a suite of locally endemic and threatened species of fauna and flora.
Complement factor H in molecular regulation of angiogenesis
Authors: Li Jiang , Wang Kaili , Starodubtseva Maria N. , Nadyrov Eldar , Kapron Carolyn M. , Hoh Josephine , Liu Ju 
Published: June 2024

Abstract
Angiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes. Complement factor H (CFH) is a plasma protein that inhibits the alternative pathway of the complement system. Loss of CFH enhances the alternative pathway and increases complement activation fragments with pro-angiogenic capacity, including complement 3a, complement 5a, and membrane attack complex. CFH protein contains binding sites for C-reactive protein, malondialdehyde, and endothelial heparan sulfates. Dysfunction of CFH prevents its interaction with these molecules and initiates pro-angiogenic events. Mutations in the CFH gene have been found in patients with age-related macular degeneration characterized by choroidal neovascularization. The Cfh-deficient mice show an increase in angiogenesis, which is decreased by administration of recombinant CFH protein. In this review, we summarize the molecular mechanisms of the anti-angiogenic effects of CFH and the regulatory mechanisms of CFH expression. The therapeutic potential of recombinant CFH protein in angiogenesis-related diseases has also been discussed.
Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications
Authors: Zhao Jinyu , Yue Ping , Mi Ningning , Li Matu , Fu Wenkang , Zhang Xianzhuo , Gao Long , Bai Mingzhen , Tian Liang , Jiang Ningzu , Lu Yawen , Ma Haidong , Dong Chunlu , Zhang Yong , Zhang Hengwei , Zhang Jinduo , Ren Yanxian , Suzuki Azumi , Wong Peng F. , Tanaka Kiyohito , Rerknimitr Rungsun , Junger Henrik H. , Cheung Tan T. , Melloul Emmanuel , Demartines Nicolas , Leung Joseph W. , Yao Jia , Yuan Jinqiu , Lin Yanyan , Schlitt Hans J. , Meng Wenbo 
Published: June 2024

Abstract
Fibrosis resulting from pathological repair secondary to recurrent or persistent tissue damage often leads to organ failure and mortality. Biliary fibrosis is a crucial but easily neglected pathological feature in hepatobiliary disorders, which may promote the development and progression of benign and malignant biliary diseases through pathological healing mechanisms secondary to biliary tract injuries. Elucidating the etiology and pathogenesis of biliary fibrosis is beneficial to the prevention and treatment of biliary diseases. In this review, we emphasized the importance of biliary fibrosis in cholangiopathies and summarized the clinical manifestations, epidemiology, and aberrant cellular composition involving the biliary ductules, cholangiocytes, immune system, fibroblasts, and the microbiome. We also focused on pivotal signaling pathways and offered insights into ongoing clinical trials and proposing a strategic approach for managing biliary fibrosis-related cholangiopathies. This review will offer a comprehensive perspective on biliary fibrosis and provide an important reference for future mechanism research and innovative therapy to prevent or reverse fibrosis.
I. Die Vorbilder der sog. Liber Papiensis-Handschriften
Authors: Shibata Takanori 
Published: June 2024

Summary
The evaluation of Liber Papiensis, an important legal collection from the 11th century, is still uncertain as the research on the manuscripts which provides a basis for empirical discussion has not been sufficiently carried out. This article discusses the existence and characteristics of common models on which the Liber Papiensis manuscripts rely by analyzing the arrangement of clauses, the annotations for their revision and the notes mentioning relevant clauses in the oldest existent Milanese manuscripts. After identifying the author of them, it will also be argued that they were produced not directly in the environment of the lawyers of Pavia, as assumed, but from the circumstances of a local judge in Turin.