bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative Assessment of Channel Migration in the Ghaghara River, Ganga Plain, India
Authors: Gautam Pawan Kumar , Singh Dhruv Sen , Singh Anoop Kumar 
Published: July 2024

ABSTRACTThe Ghaghara River is one of the longest tributary of the Ganga River. The Ghaghara, a snow fed river is well known for channel shifting/migration. It was analyzed for lateral migration using multi-temporal satellite images and SOI toposheets. It shows 4.2 to 6.1 km lateral migration in last 45 years (1975–2020) between Bahraich and Deoria in the state of Uttar Pradesh. The lateral migration on the left side of the river (NNE) is 6144, 4838, 6475 and 4755 m, whereas on the right side (SSW) is 7021, 4555, 4718 and 4257 m during 1975–1990, 1975–2000, 1975–2010 and 1975–2020, respectively. The rate of migration (m/year) on left side (NNE) is 410, 194, 185 and 106, whereas on the right side (SSW) is 468, 182, 135 and 95 during 1975–1990, 1975–2000, 1975–2010 and 1975–2020, respectively. The major factors such as heavy precipitation, reactivation of chute channels, deposition of sediments, breaching of embankments and sand mining etc. might be responsible for the lateral migration of the river. Human settlements should be constructed away from the migration-prone area and regular monitoring and management system needs to be in place to mitigate the impacts of such natural events.
Site Characterization and Shallow Shear Velocity through HVSR Measurements around the Hyderabad Metropolitan Region, India
Authors: Sivaram K. , Mandal Prantik , Biswas Rahul , Prasad B.N.V. , Dixith M. Sai , Madhusudhan S. 
Published: July 2024

ABSTRACT
We investigate the site characterization and shallow shear velocity profiles from the analysis of the Horizontal to Vertical Spectral ratio (HVSR) around the Hyderabad metropolitan region (HMR), which falls under the southern Indian shield. This work uses both the ambient noise and microearthquake data to compute the HVSR, and additionally the Random Decrement technique to compute the HVSR of extracted Rayleigh waves. This study indicates comparable HVSR curves at each station with the three different datasets, from which we obtain the average dominant frequency (f0) and amplification value (A0). They are further used to calculate the seismic vulnerability index value (Kg). We observe that the value of f0 around the HMR is not fixed, but is varying in the range of 3.4 to 18 Hz, whereas the value of A0 is in the range of 1.7 to 12 approximately and Kg in the range of 0.16 to 1.68 approximately, with an exception of ∼ 33 at VKB (Vikarabad) station, which may be due to a local unconsolidated sub-surface structure. Based on the Diffused Field Assumption (DFA), we invert the average HVSR curves and average dispersion curves of Rayleigh waves, and provide the shallow shear velocity profiles up to 300 m, along with an approximate estimate of VS30 (in upper 30 m depth). The estimated VS30 values vary between 911 to 3143 m/s, falling under the classifications A and B (mostly Hard Rock and Rock type) of National Earthquake Hazards Reduction Program (NEHRP) (BSSC, 2001). However, our study shows some stations with shear velocity inversions at shallow depths within 300 m, indicating layers of low velocity, needing further study. In the absence of detailed near-surface findings, these findings are valuable inputs for geotechnical engineering studies and urban-city planning around the HMR, and emphasizes the effectiveness the HVSR method to determine sub-surface topography and/or unknown soil structures as an economical investigation viability.
Identification of Possible Incoming Runoff using Different Combinations of Extreme Rainfall Events in a Semi-arid Context: Banas River, Bisalpur Dam Catchment
Authors: Kachhawa Nitin Singh , Agnihotri Prasit Girish 
Published: July 2024

ABSTRACT
Event-based hydrologic models are very useful to predict peak flow and flood volume, particularly in semi-arid regions. In HEC-HMS software methods selected for loss, transformation, routing and base flow were soil conservation service (SCS) curve number (CN), SCS unit hydrograph (UH), Muskingum and recession, respectively. A total of six extreme events from the year 2011 to 2019 were selected, out of which four were used for calibration, one each for validation and application. The developed model can identify the peak discharge and flood volume satisfactorily at 2-hour intervals. During validation performance statistical viz. percent difference in runoff volume (DV%), percent difference in peak flow (DP%), Nash Sutcliffe Efficiency (NSE), percent bias (%BIAS), coefficient of determination (R2) and ratio of the root mean square error to the standard deviation (RSR) were −3.68, −25.93, 0.52, 3.52, 0.53 and 0.69, respectively. The sensitivity analysis revealed that the CN is the highest sensitive parameter followed by the storage time constant (K), which affects the peak discharge. Whereas, for flood volume, CN is the highest sensitive parameter followed by the recession constant (Rc). The relative sensitivity of CN for peak flow and flood volume were 2.11 and 1.73, respectively. Out of center maximum rainfall (CeMR) and cumulative maximum rainfall (CuMR) distribution, CeMR distribution has given higher peak discharge for all rainfall duration. The rainfall characteristics of the 2016 flood event suggest a hypothetical 9-day rainfall duration can be considered. The 9-day event with CeMR gives 70.64% higher discharge as compared to the observed peak discharge during the 2016 flood.
Modulation of homologous recombination gene activity in breast tumor cells in an <i>in vitro</i> model
Authors: Tsyganov M. M. , Frolova A. A. , Kravtsova E. A. , Tsydenova I. A. , Ibragimova M. K. 
Published: July 2024

Introduction. It has been established that the presence of homologous recombination deficiency in a breast tumor is associated with the effectiveness of treatment. But despite the high chemosensitivity of the tumor to DNA-damaging agents, complete pathological responses to treatment are very rare. And this process may be based on a change in the somatic status of BRCA1, that is, a reversion and return of the wild-type allele occurs and the DNA repair function is restored.Aim. To evaluate changes in the presence of chromosomal aberrations and the expression profile of the main genes of homologous recombination in cell models of breast cancer under the influence of cisplatin and docetaxel.Materials and methods. The study was conducted on breast cancer tumor cell cultures: MCF-7, MDA-MB-231 and MDA-MB-468. A cell model of drug resistance was obtained for two drugs: cisplatin and docetaxel. RNA and DNA were isolated from cell suspension using the RNeasy Plus Mini Kit and QIAamp DNA Mini Kit (Qiagen, Germany), respectively. The expression level of homologous recombination genes was assessed using reverse transcription polymerase chain reaction. To assess the presence of chromosomal aberrations, microarray analysis was performed on DNA chips.Results. Restoration of normal copy number for the BRCA1, CDK12, CHEK1 and RAD51D genes in MCF-7 under the influence of cisplatin was shown. For BRCA2 and PALB2, amplifications were detected. A statistically significant increase in the expression of the BRCA1 (p = 0.04), BRCA2 (p = 0.02), PALB2 (p = 0.01) and RAD51D (p = 0.05) genes was also shown. MDAMB-231 shows that all identified loci with deletions, where the BRCA2, BARD1, CHEK2, PALB2 and RAD54L genes are localized, are restored to normal copy number by cisplatin. The appearance of amplifications was registered for BRCA1, BRIP1, FANCL, RAD51B, PARP1. A similar result was shown for docetaxel. An increase in the expression level is typical for the genes BRCA1 (p = 0.02), BRCA2 (p = 0.02), CHEK2 (p = 0.05), FANCL (p = 0.04), PALB2 (p = 0.05), RAD51C (p = 0.02), PARP1 (p = 0.02), which corresponds to the appearance of amplifications. In the MDA-MB-468 cell culture, an increase in the copy number of only the BRCA1 gene is observed. The effect of docetaxel has no effect on this cell culture. The level of BRCA1 expression increases in direct proportion to the duration of drug action.Conclusion. Thus, the study showed that under the influence of cisplatin, reversion of not only homologous recombination gene mutations, but also other disorders can occur.
Depolymerization of tubulin as the main molecular mechanism of the cytotoxic and antitumor activity of pyrrole-containing heterocyclic compounds
Authors: Galembikova A. R. , Dunaev P. D. , Ivoilova T. V. , Gilyazova A. I. , Galyautdinova A. E. , Mikheeva E. G. , Zykova S. S. , Igidov N. M. , Kopnin P. B. , Boichuk S. V. 
Published: July 2024

Introduction. Microtubules are highly dynamic polymers of α, β-tubulin dimers involves in a broad spectrum of the processes, such as intracellular transport and cell proliferation. This makes them an attractive molecular target for anti-cancer therapies. Substances that affect the dynamic state of tubulin microtubules are known as the mitotic poisons that are effectiveand widely used in the chemotherapy of various tumors. Mitotic poisons are able to interfere with polymerization (stabilization) or depolymerization of tubulin, which in turn leads to the arrest of cells in the M-phase (named as a mitotic catastrophe) and their subsequent death via activation of apoptotic mechanisms. However, the effectiveness of MP-based therapies is gradually decreasing over the time due to development of multiple drug resistance mechanisms in cancer cells. Thus, development of novel compounds selectively targeting tubulin and effectively overcoming multiple drugresistance phenotype in cancer is an urgent need in current oncology. Aim. To examine the cytotoxic and antitumor activities of several pyrrole-containing heterocyclic compounds (EPC-91, EPC-92 and PCA-93) against cancer cell lines with epithelial and mesenchymal origin, including those with multiple drug resistance phenotype. Materials and methods. Studies were performed on parental human cancer cell lines – triple-negative breast cancer HCC1806, gastrointestinal stromal tumor GIST T-1, osteosarcoma SaOS-2, – sensitive to chemotherapy (paclitaxel, doxorubicin) and their resistant sublines (HCC1806 Tx-R, GIST T-1 Tx-R, SaOS-2 Dox-R), as well as on murine colorectal adenocarcinoma cell line Colon-26, exhibiting primary resistance to the aforementioned chemotherapeutic agents. Results. The cytotoxic activities of EPC-91 and PCA-93 were due to their abilities to depolymerize tubulin. The results of immunofluorescence microscopy and Western blotting indicated that the compounds disrupt assembly of tubulin microtubules and prevent polymerization of α-tubulin in cancer cells. Inhibition of tubulin polymerizations led to significant increasein number of round-shaped and phospho-histone 3 (e. g. mitotic) cells, followed by their death through apoptosis. PCA-93 also exhibited potent anti-tumor effect against Colon-26 cells due to its anti-proliferative and proapoptotic activities. Conclusion. The data shown here illustrates potent cytotoxic activities of EPC-91 and PCA-93 against multiple cancer cell lines in vitro including those with multiple drug resistance phenotype. Similarly, PCA-93 was found to be highly effective against Colon-26 cell in vivo, thereby illustrating the attractive platform for the development of novel pyrrole-based agents exhibiting potent anti-tumor activities.
Seismic Hazard Assessment in the Southeastern Korean Peninsula for Large Earthquakes in Northern Kyushu, Japan: A 3D Numerical Simulation of Pseudodynamic Rupture Scenarios
Authors: Lee Jaeseok , Rhie Junkee , Cheon Hwa Sung 
Published: July 2024

Abstract
Active fault segments in the Northern Kyushu area are of concern in seismic hazard analysis of the southeastern Korean Peninsula (KP) due to their proximity. In this study, we numerically simulate the peak ground motions at the southeastern KP for Mw 6.7–7.1 earthquake scenarios at five major active fault segments located in northern Kyushu: Kego SouthEastern, Nishiyama OshimaOki, Nishiyama Nishiyama, Kikugawa Central, and Kikugawa Northern fault segments. We conducted fully 3D seismic-wave propagation simulations integrating 3D seismic velocity model and earthquake scenarios generated through pseudodynamic rupture modeling. After applying the region-specific attenuation value, the predicted peak ground velocities (PGVs) ranged from 0.18 cm/s (modified Mercalli intensity [MMI] III) to 26.76 cm/s (MMI VIII), depending on the earthquake scenarios. The PGV distributions were influenced by several factors, such as crustal velocity anomalies, rupture directivity, and the distribution of source parameters on the fault plane. Despite the fixed fault geometries, magnitudes, and hypocenters, significant variations in peak ground-motion distributions were simulated due to differences in the source statistics. The estimated probability density distributions of PGV indicated a significant likelihood of peak ground motions surpassing 20 cm/s in the Yeongnam Province. Furthermore, we identify a linear relationship between the average PGV values and standard deviation across 20 scenarios for each fault segment, to quantify the uncertainty in the PGV distributions.
ВПЛИВ СОЦІАЛЬНО-ПСИХОЛОГІЧНИХ ЧИННИКІВ НА УПРАВЛІННЯ ЛЮДСЬКИМИ РЕСУРСАМИ В УМОВАХ КРИЗОВИХ ЯВИЩ
Authors: Яковенко В. Г. , Громова О. В. 
Published: July 2024

Стаття присвячена проблемам управління людськими ресурсами в умовах війни. Розглянуто вплив психологічного стану працівника підприємства на результати роботи в кризових ситуаціях. Розглянуто необхідність формування додаткових стимулів життєстійкості. Зазначено, що сьогодні ми ще не в повній мірі усвідомлюємо психологічні наслідки для людей, що постраждали від військових дій, що в свою чергу впливатиме на працездатність населення України. Викорстали «Тест життєстійкості С.Мадді» та «Опитувальник SACS (С.Хобфолл)» для аналізу життєстійкість працівників підприємства. Провели анонімне опитування серед 20 працівників підприємства різних вікових категорій та різних фахових напрямів роботи та сформували результат опитування. Також в статті приділено увагу чинникам, які впливають на рівень забезпеченості трудовими ресурсами підприємств залізничного транспорту. Доведено необхідність формування ефективної системи з різних методів мотивування, щоб запобігти демотивації працівників.
Analisis Nilai Pendidikan Karakter Pada Novel Catatan Juang Karya Fiersa Besari dan Pemanfaatannya dalam Pembelajaran Menganalisis Novel Kelas X SMK
Authors: Utari Rindi , Subaweh Ahmad Maskur , Fajri Khoirul 
Published: July 2024

<p>Penelitian ini bertujuan untuk mengetahui nilai pendidikan karakter yang terdapat dalam novel Catatan Juang Karya Fiersa Besari yang diterbitkan oleh Media kita cetakan pertama 2017. Pada penelitian ini menggunakan penelitian deskriptif kualitatif, yakni mendeskripsikan dan menjawab suatu fenomena atau peristiwa yang terjadi pada saat ini. Teknik pengumpulan data yang digunakan yaitu menggunakan studi dokumen (pencatatan) terhadap teks novel Catatan Juang Karya Fiersa Besari dengan instrument penelitian menggunakan peneliti itu sendiri, yang artinya peneliti melakukan pembacaan kemudian penganalisisan terhadap sumber data secara berulang-ulang. Adapun teknik analisis datanya dengan cara sebagai berikut. a) peneliti membaca secara kritis b) peneliti memahami isi bacaan dan mengaitkan sesuai masalah yang akan diteliti. c) mengumpulkan data dan menandai nilai pendidikan karakter yang dibutuhkan dalam novel. d) mendeskripsikan nilai-nilai pendidikan karakter dan menarik kesimpulan dari penelitian. e) menyusun bahan ajar. f) melakukan validasi bahan ajar. Hasil penelitian ini menunjukan bahwa nilai pendidikan karakter yang muncul adalah religius, jujur, disiplin, gemar membaca, dan peduli sosial. Serta pemanfaatannya dalam menganalisis novel terhadap bahan ajar modul tersebut.</p><div id="pip-toast"> </div>
The Effect of The Implementation of Auditory, Intellectually, Repetition (AIR) Learning Model Assisted by Talking Sticks on Students' Argumentation Skills on Buffer Solution Material
Authors: Cahyani Sukma Yulia Dwi , Ningrum Lis Setiyo 
Published: July 2024

<p>Tantangan di dunia pendidikan pada abad 21 pendidik dituntut untuk mengembangkan model pembelajaran dalam kelas yang menarik dan menuntut peserta didik untuk memiliki keterampilan 4C salah satunya yaitu <em>communication</em>, dimana kemampuan ini berperan penting dalam pembelajaran sains yaitu berargumentasi ilmiah. Penelitian ini bertujuan untuk menganalisis pengaruh implementasi model pembelajaran <em>Auditory, Intellectually, Repetition</em> (AIR) berbantuan <em>Talking Stick</em> terhadap kemampuan argumentasi peserta didik pada materi larutan penyangga. Jenis penelitian ini adalah penelitian kuantitatif dengan desain penelitian <em>pre test-post test non equivalen control group design</em>. Teknik pengambilan sampel yang digunakan adalah <em>cluster random sampling</em>. Teknik pengumpulan data menggunakan instrumen soal tes, observasi, dokumentasi, dan wawancara. Berdasarkan hasil penelitian menunjukkan bahwa implementasi model pembelajaran AIR berbantuan <em>talking stick </em>berpengaruh terhadap kemampuan argumentasi peserta didik. Hal ini dibuktikan melalui data hasil uji N-gain kelas eksperimen (0,77) lebih tinggi daripada kelas kontrol (0,68) serta hasil uji hipotesis <em>independent sample t-test</em> dengan nilai <em>sig. 2-tailed</em> sebesar 0,012. Artinya, Ha diterima atau implementasi model pembelajaran AIR berbantuan <em>talking stick </em>berpengaruh terhadap kemampuan berargumentasi peserta didik.</p><div id="pip-toast"> </div>
Design of a Simple Chemical Equilibrium Tool Using Natural Dyes
Authors: Asyaura Hiraluna , Kartika Luthfia Rahma , Kholidah Kholidah 
Published: July 2024

<p>Materi kimia akan mudah dipahami oleh siswa apabila pengetahuan yang didapatkan dapat diimplementasikan dan dapat ditemukan dalam kehidupan sehari-hari. Oleh karena itu, dibutuhkan media praktikum yang sederhana dan dapat memberi pemahaman kedapa siswa terkait materi kesetimbangan kimia. Tujuan dari penelitian ini adalah untuk mengembangkan alat praktikum sederhana kesetimbangan kimia. Metode penelitian yang digunakan dalam penelitian ini adalah metode pengembangan. Praktikum merupakan salah satu kegiatan yang dapat dilakukan untuk mencapai tujuan pembelajaran. Konsep yang diterapkan pada alat praktikum ini yaitu adanya pergeseran kesetimbangan yang disebabkan oleh adanya pengaruh tekanan atau konsentrasi. Untuk menghindari dampak buruk dari penggunaan pewarna sintetik maka diterapkan adanya prinsip green chemistry yaitu penggunaan pewarna alami dalam larutan yang memiliki konsentrasi yang berbeda. Warna tersebut berasal dari daun pandan (hijau) dan buah bit (merah). Harapnya rancangan alat praktikum ini dapat membantu siswa dalam memahami konsep pergeseran kesetimbangan serta dapat menerapkan prinsip green chemistry yaitu penggunaan bahan-bahan yang aman dan tidak mencemari lingkungan.</p><div id="pip-toast"> </div>
Oil and Gas Content of the South Caspian Basin
Authors: Poletayev A.V. , Poletayeva E.V. 
Published: July 2024

Abstract
—We have compiled maps of areal isotope composition changes and constructed graphs of gas HC distribution depending on the stratigraphic age of the host rocks and graphs of isotope composition changes depending on the depth of sampling to study the hydrocarbon potential of the deep-seated oil and gas pools of the South Caspian Basin. The genesis of gas was studied using the techniques elaborated by M. Schoell and A. James. Two stages of hydrocarbon formation have been established by study of various kinds of gas manifestation. The first stage (Miocene–Eocene) began in the deposits underlying the Productive Series and continued up to the deposits of the latter. This stage was characterized by a frequent change in the directions of both downward and upward movements of gases. The second stage of hydrocarbon formation (Anthropogene–Pliocene) began in the deposits of the Productive Series and was characterized by a change in the regional geodynamic setting. Avalanche sedimentation and the predominance of downward movements over upward ones favored the accumulation of thick sediments at the time when the Productive Series formed. The sedimentation and tectonic processes (downwarping) in the deep-water zone of the basin led to harsh thermobaric conditions in the sedimentary strata. A detailed analysis of the results of gas survey in the deep-water zone of the South Caspian Basin has shown gas generation with a predominance of two components, methane and ethane. Study of the trends of temporal and areal hydrocarbon migration and of the areas of oil and gas generation makes it possible to reveal structures with evidence for large and giant hydrocarbon reserves. We have established that gas hydrocarbons in the bottom and upper-section sediments of the southern Caspian Sea are intimately related to the sources of hydrocarbons, their migration, and other processes running in the deep-seated sediments and in the upper section.
Heat Flow in the Northeastern Continental Margin of Russia
Authors: Gornov P.Yu. , Duchkov A.D. 
Published: July 2024

Abstract
—This work is set out to summarize, analyze and revisit results of the geothermal studies carried out in Northeast Russia. A catalog of measured heat flow values has been compiled, and on its basis a map of the region’s heat flow distribution has been constructed. Geodynamic activity of the tectonic structures in Northeast Russia, their thermal regime in which the heat flow is a critical indicator, is largely determined by the interaction between the Eurasian and North American lithospheric plates and smaller-order plates located in the northeastern part of the Asian continent. The areas of interaction between the Eurasian and North American lithospheric plates are marked by the Arctic-Asian seismic belt, which is characterized by intense orogenesis, modern volcanism, active seismicity, diverse geothermal regimes, and large heterogeneity of measured heat flow values. On the Chukotka Peninsula, the helium isotope method was used to estimate heat flow values. It is proposed to consider the class of geodynamic activity of tectonic structures as one of the factors of the geothermal regime.
2024 SPE Pioneers of Improved Oil Recovery
Authors: Pallanich Jennifer 
Published: July 2024

Reservoirs present plenty of complexity and mystery. Four oil recovery experts have helped remove some of those mysteries, taming the complex to boost production.
From developing preformed particle gels that improve conformance when fractures cause severe channeling to simulating enhanced oil recovery (EOR) processes in the reservoir to identifying the aqueous stability concept to demonstrating the distance polymer solutions can travel without degradation, the four 2024 recipients of the 2024 Improved Oil Recovery (IOR) Pioneer Award have made a “sustained and important contribution to increased oil recovery,” Randy Seright, New Mexico Tech, 2024 Pioneer selection committee chairman and 2008 honoree, told JPT.
Seright, four other previous recipients of the recognition, and 2024 SPE IOR Conference General Chairman Tom McCoy evaluated a field of 16 nominees for the lifetime achievement honor and selected four who have throughout their careers “made the most lasting and significant contributions to IOR,” Seright said. “It’s why we are where we are today with respect to IOR.”
The 2024 IOR Pioneer recipients who were honored during the biannual IOR conference in Tulsa in April are Baojun Bai, professor of petroleum engineering, who sits in the Lester Birbeck Endowed Chair at Missouri University of Science and Technology (Missouri S&T) in Rolla, Missouri; Mojdeh Delshad, research professor in the Hildebrand Department of Petroleum and Geosystems Engineering at The University of Texas at Austin (UT-Austin); Varadarajan Dwarakanath, team lead for chemical EOR at the Chevron Technology Center in Houston; and Stephane Jouenne, who previously led a TotalEnergies team dedicated to surface and subsurface research topics for polymer flooding and is currently CO2 capture project coordinator at TotalEnergies.
“It’s the most prestigious award given out in IOR,” Seright said.