bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethnicity and suicide attempt: analysis in bipolar disorder and schizophrenia
Authors: Bani-Fatemi Ali , Polsinelli Gina , Kennedy James L , De Luca Vincenzo 
Published: October 2013

Abstract

Background
Evidence is mixed as to whether White Europeans are at a higher risk for suicide attempts or completions compared to other ethnic groups. The present analysis assessed whether risk for suicide attempt was associated with White European ethnicity in 907 subjects with schizophrenia or bipolar disorder.

Methods
Subjects were diagnosed using the Structured Clinical Interview for DSM-IV, and ethnicity was determined by self-report. Subjects were recruited from psychiatric care centers in Toronto, Canada. Logistic regression correcting for clinical covariates like age, gender and diagnosis, was used in this study.

Results
We found no difference in suicide attempter status in white and non-white subjects who were diagnosed with schizophrenia and bipolar disorder.

Conclusion
Our study does not support the evidence that White-European patients in North America are at higher risk for suicide attempt compared to non-European descent subjects. However, this result has to be replicated in larger studies in patients with these disorders.
Adrenomedullin delivery in microsphere-scaffold composite for remodeling of the alveolar bone following tooth extraction: an experimental study in the rat
Authors: Wang Lin , Zheng Ling , Li Chunyan , Dong Shujun , A Lan , Zhou Yanmin 
Published: October 2013

Abstract

Background
Alveolar ridge resorption, as a significant problem in implant and restorative dentistry, has long been considered as an inevitable outcome following tooth extraction. Recently, adrenomedullin (ADM) is reported to be able to stimulate the proliferation and migration of various cells including osteoblasts. The purpose of this study was to investigate the influence of local ADM application in the tooth extraction socket in vivo.

Methods
Chitosan micropheres were developed by an emulsion-ionic cross-linking method for ADM delivery. Poly (L -lactic-co-glycolic) acid (PLGA) and nano-hydroxyapatite (nHA) were used to prepare scaffolds to contain the micrspheres with ADM. In vivo experiment was evaluated by transplanting the composite into the rat socket right after the incisor extraction. After 4, 8, 12 weeks implantation, radiographic and histological tests were carried out to evaluate the effect of released ADM on the alveolar bone.

Results
The microspheres had a spherical structure and a relative rough and uniform surface, and the particle size was under a normal distribution, with the average diameter of 38.59 μm. The scaffolds had open and interconnected pores. In addition, the high porosity of the composite was 88.93%. Radiographic and histological examination revealed that the PLGA/nHA/CMs/ADM composite could accelerate the alveolar bone remodeling and reduce the residual ridge resorption compared with the PLGA/nHA/CMs scaffold.

Conclusions
The results of this study suggest that local application of ADM has the potential to preserve the residual alveolar ridge and accelerate the alveolar bone remodeling.
Effects of exercise and diet change on cognition function and synaptic plasticity in high fat diet induced obese rats
Authors: Woo Jinhee , Shin Ki Ok , Park So Young , Jang Ki Soeng , Kang Sunghwun 
Published: October 2013

Abstract

Background
Nutritional imbalance-induced obesity causes a variety of diseases and in particular is an important cause of cognitive function decline. This study was performed on Sprague Dawley (SD) rats with 13-weeks of high fat diet-induced obesity in connection to the effects of regular exercise and dietary control for 8 weeks on the synaptic plasticity and cognitive abilities of brain.

Methods
Four weeks-old SD rats were adopted classified into normal-normal diet-sedentary (NNS, n = 8), obesity-high fat diet-sedentary (OHS, n = 8), obesity-high fat diet-training (OHT, n = 8), obesity-normal diet-sedentary (ONS, n = 8) and obesity- normal diet-training (ONT, n = 8). The exercise program consisted of a treadmill exercise administered at a speed of 8 m/min for 1–4 weeks, and 14 m/min for 5–8 weeks. The Western blot method was used to measure the expression of NGF, BDNF, p38MAPK and p-p38MAPK proteins in hippocampus of the brain, and expressions of NGF, BDNF, TrkA, TrkB, CREB and synapsin1 mRNA were analyzed through qRT-PCR.

Results
The results suggest cognitive function-related protein levels and mRNA expression to be significantly decreased in the hippocampus of obese rats, and synaptic plasticity as well as cognitive function signaling sub-pathway factors were also significantly decreased. In addition, 8-weeks exercises and treatment by dietary change had induced significant increase of cognitive function-related protein levels and mRNA expression as well as synaptic plasticity and cognitive function signaling sub-pathway factors in obese rats. In particular, the combined treatment had presented even more positive effect.

Conclusions
Therefore, it was determined that the high fat diet-induced obesity decreases plasticity and cognitive function of the brain, but was identified as being improved by exercises and dietary changes. In particular, it is considered that regular exercise has positive effects on memory span and learning capacity unlike dietary control.
Anti-CEA-functionalized superparamagnetic iron oxide nanoparticles for examining colorectal tumors in vivo
Authors: Huang Kai-Wen , Chieh Jen-Jie , Lin In-Tsang , Horng Herng-Er , Yang Hong-Chang , Hong Chin-Yih 
Published: October 2013

Abstract
Although the biomarker carcinoembryonic antigen (CEA) is expressed in colorectal tumors, the utility of an anti-CEA-functionalized image medium is powerful for in vivo positioning of colorectal tumors. With a risk of superparamagnetic iron oxide nanoparticles (SPIONPs) that is lower for animals than other material carriers, anti-CEA-functionalized SPIONPs were synthesized in this study for labeling colorectal tumors by conducting different preoperatively and intraoperatively in vivo examinations. In magnetic resonance imaging (MRI), the image variation of colorectal tumors reached the maximum at approximately 24 h. However, because MRI requires a nonmetal environment, it was limited to preoperative imaging. With the potentiality of in vivo screening and intraoperative positioning during surgery, the scanning superconducting-quantum-interference-device biosusceptometry (SSB) was adopted, showing the favorable agreement of time-varied intensity with MRI. Furthermore, biological methodologies of different tissue staining methods and inductively coupled plasma (ICP) yielded consistent results, proving that the obtained in vivo results occurred because of targeted anti-CEA SPIONPs. This indicates that developed anti-CEA SPIONPs owe the utilities as an image medium of these in vivo methodologies.
Qualitative properties of a cooperative degenerate Lotka-Volterra model
Authors: Sun Jiebao , Zhang Dazhi , Wu Boying 
Published: October 2013

Abstract
This paper considers a kind of degenerate parabolic systems. First, we consider the initial boundary value problem of the two-species degenerate parabolic cooperative system. By using the method of a parabolic regularization and energy estimate, we establish the existence of the weak solution of the problem. Then we establish the comparison principle and discuss the uniqueness and the uniform bound. At last, we consider the periodic boundary value problem of the system. By constructing a pair of ordered upper and lower solutions, we establish the existence of nontrivial nonnegative periodic solutions.
Mosaic pregnancy after transfer of a “euploid” blastocyst screened by DNA microarray
Authors: Haddad Ghassan , He Wenyin , Gill Jimmy , Witz Craig , Wang Cassie , Kaskar Khalied , Wang Weihua 
Published: October 2013

Abstract

Background
High proportions of human embryos produced by in vitro fertilization are aneuploidy and mosaic. DNA microarray is one of the most practical screening methods to select euploid embryos for transfer. However, mosaic pregnancy is still possible due to embryonic mosacism. Here we report a successful pregnancy after transfer of a mosaic blastocyst with euploid inner cell mass.

Methods
A woman with a previous trisomy 13 pregnancy pursued infertility treatment with preimplantation genetic screening by a trophectoderm biopsy and DNA microarray. NimbleGen oligonucleotide DNA microarray was applied to biopsied samples from 13 blastocysts. A euploid blastocyst was transferred to the patient and subsequent prenatal cytogenetic tests were performed by FISH and/or G banding.

Results
Following DNA microarray, it was found that 5 blastocysts were euploid and 8 were aneuploidy. Transfer of one euploid blastocyst resulted in a clinical pregnancy. Prenatal cytogenetic tests of samples biopsied from chorionic villi sample showed both trisomy 21 (47 XX, +21) and euploid (46, XX) cells. Further prenatal cytogenetic test with a sample from amniotic fluid indicated that all cells were euploid (46, XX). The pregnancy was continued and a healthy girl was delivered after 41 weeks of gestation.

Conclusions
This is the first report to indicate a mosaic pregnancy after transfer of a “euploid” blastocyst that was screened by DNA microarray, and the case further confirms that mosaicism is present in human blastocysts produced by in vitro fertilization.
Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/− fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study
Authors: Schlimp Christoph J , Voelckel Wolfgang , Inaba Kenji , Maegele Marc , Schöchl Herbert 
Published: October 2013

Abstract

Background
Low plasma fibrinogen concentration is a predictor of poor outcome in major trauma patients. The role of fibrinogen concentrate for rapidly increasing fibrinogen plasma levels in severe trauma is not well defined.

Methods
In this retrospective study we included severe trauma patients treated with fibrinogen concentrate alone (FC group), fibrinogen concentrate with prothrombin complex concentrate (FC–PCC group) or fibrinogen concentrate with PCC and fresh frozen plasma (FC–PCC–FFP group). PCC was generally administered as the second step of intraoperative therapy, while FFP was only administered as a third step. All patients received ≥1 g fibrinogen concentrate within 24 hours. Plasma fibrinogen concentration and ROTEM parameters upon emergency room (ER) admission, intensive care unit (ICU) admission, and after 24 hours were analysed.

Results
Among 157 patients fulfilling the inclusion criteria, 83% were male; mean age was 44 years and median injury severity score (ISS) was 29. Standard coagulation tests reflected increasing severity of coagulopathy with increasing complexity of haemostatic therapy (highest severity in the FC–PCC–FFP group; p < 0.0001). Total 24-hour fibrinogen concentrate dose also increased with complexity of haemostatic therapy. Plasma fibrinogen concentration was maintained, with no significant difference between ER admission and ICU admission in all patient groups. FIBTEM clot firmness at 10 minutes (CA10) was similarly maintained, albeit with a small increase in the FC–PCC group. Fibrinogen concentration and FIBTEM CA10 were within the normal range in all groups at 24 hours. The ratio of fibrinogen concentrate to red blood cells (g:U) ranged between 0.7:1.0 and 1.0:1.0.

Conclusion
Fibrinogen concentrate therapy maintained fibrinogen concentration and FIBTEM CA10 during the initial phase of trauma care until ICU admission. After 24 hours, these parameters were comparable between the three groups and within the normal range for each of them. Further studies are warranted to investigate the effect of fibrinogen concentrate on clinical outcomes.
NCX3 regulates mitochondrial calcium handling through AKAP121-anchored signaling complex and prevents hypoxia-induced cell death
Authors: Scorziello Antonella , Savoia Claudia , Sisalli Maria Josè , Adornetto Annagrazia , Secondo Agnese , Boscia Francesca , Esposito Alba , Polishchuk Elena V. , Polishchuk Roman S. , Molinaro Pasquale , Carlucci Annalisa , Lignitto Luca , Di Renzo Gianfranco , Feliciello Antonio , Annunziato Lucio 
Published: October 2013

The mitochondrial influx and efflux calcium pathways play a relevant role in cytosolic and mitochondrial calcium homeostasis and contribute to the regulation of mitochondrial functions in neurons. The mitochondrial Na+/Ca2+ exchanger, although hypothesized in 1974, has been primarily investigated only from a functional point of view and its identity and localization in the mitochondria have been a matter of debate over the last three decades. Recently, a lithium-dependent sodium/calcium exchanger extruding calcium from the matrix has been found in the inner mitochondrial membrane of neuronal cells. However, evidence has been provided that the outer membrane is impermeable to calcium efflux into the cytoplasm.
In this study, we have demonstrated for the first time that the nuclear encoded NCX3 isoform (a) is localized on the outer mitochondrial membrane (OMM) of neurons, (b) co-localizes and immunoprecipitates with AKAP121, a member of the protein kinase A anchoring proteins (AKAPs) present on the outer membrane, (c) extrudes calcium from mitochondria through AKAP121 interaction in a PKA-mediated manner, both under normoxia and hypoxia, and (d) improves cell survival when it works in the Ca2+ efflux mode at the level of the OMM.
Collectively, these results suggest that, in neurons, NCX3 regulates mitochondrial calcium handling from the OMM through an AKAP121-anchored signalling complex, thus promoting cell survival during hypoxia.
Preparation and Characterization of Oligo(9,9′-di-p-tolyl-3,3′-bicarbazyl) and Its Application to Transparent Conducting Materials
Authors: Kim Youngwoong , Tokuda Takuya , Yagishita Fumitoshi , Masu Hyuma , Kubo Minako , Murashiro Katsuyuki , Hoshino Katsuyoshi 
Published: October 2013

Abstract
The oxidation of 9-p-tolylcarbazole by iron(III) perchlorate in acetonitrile produces oligo(9,9′-di-p-tolyl-3,3′-bicarbazyl), partially doped with perchlorate. To the chloroform solution of the oligomers, we added metals to produce hybrid solutions. The hybrid films, prepared by applying the solutions onto a glass plate, exhibited good transparencies (90% or above in the visible region) and electrical conductivities of 4.1 × 10−3 S cm−1.
Stimuli-responsive Unimer Nanoparticles Composed of Poly(amino acid) Derivatives as Promising Protein-mimetic Drug Carriers
Authors: Piyapakorn Phassamon , Akagi Takami , Akashi Mitsuru 
Published: October 2013

Abstract
Stimuli-responsive unimer nanoparticles (NPs) composed of hydrophobized poly(γ-glutamic acid) were successfully prepared by a combination of hydrophobic interactions and disulfide bonds. The formation of hydrophobic associations and the existence of disulfide bonds were confirmed by UV spectroscopy and by treatment with dithiothreitol, respectively. Moreover, the release of hydrophobic drugs in response to a reducing agent was observed when compared to nonstimulus unimer NPs. These 10 nm-sized unimer NPs will be useful as reduction-responsive carriers.
Unique Synthetic Approach toward a Phosphaalkene: Synthesis of a Selenium-substituted Phosphaalkene with Bulky Substituents
Authors: Sugamata Koh , Sasamori Takahiro , Tokitoh Norihiro 
Published: October 2013

Abstract
A selenium-substituted phosphaalkene, (Me3Si)2C=PSeTrp (1, Trp: 9-triptycyl), was synthesized by two methods, substitution reaction of (Me3Si)2C=PCl (3) with TrpSeLi, and treatment of TsiP(Cl)SeTrp (4, Tsi: C(SiMe3)3) with a catalytic amount of AlCl3. The newly obtained phosphaalkene was characterized in detail.
On Portfolio Choice with Savoring and Disappointment
Authors: Jouini Elyès , Karehnke Paul , Napp Clotilde 
Published: October 2013

We revisit the model proposed by Gollier and Muermann [Gollier C, Muermann A (2010) Optimal choice and beliefs with ex ante savoring and ex post disappointment. Management Sci. 56(8):1272–1284; hereafter, GM]. In the GM model, for a given lottery, agents form anticipated expected payoffs and the set of possible anticipations is assumed to be exogenously fixed. We propose sets of possible anticipations that are endogenously determined. This permits us to compare and evaluate in a consistent manner lotteries with different supports and to revisit the portfolio choice problem. We obtain new conclusions and interesting insights. Our extended model can rationalize a variety of empirically observed puzzles such as a positive demand for assets with negative expected returns, preference for skewed returns, and underdiversification of portfolios. This paper was accepted by Rakesh Sarin, decision analysis.
Normal isometric strength of rotator cuff muscles in adults
Authors: Chezar A. , Berkovitch Y. , Haddad M. , Keren Y. , Soudry M. , Rosenberg N. 
Published: October 2013

ObjectivesThe most prevalent disorders of the shoulder are related to the muscles of rotator cuff. In order to develop a mechanical method for the evaluation of the rotator cuff muscles, we created a database of isometric force generation by the rotator cuff muscles in normal adult population. We hypothesised the existence of variations according to age, gender and dominancy of limb.MethodsA total of 400 healthy adult volunteers were tested, classified into groups of 50 men and women for each decade of life. Maximal isometric force was measured at standardised positions for supraspinatus, infraspinatus and subscapularis muscles in both shoulders in every person. Torque of the force was calculated and normalised to lean body mass. The profiles of mean torque-time curves for each age and gender group were compared.ResultsOur data showed that men gradually gained maximal strength in the fifth decade, and showed decreased strength in the sixth. In women the maximal strength was gained in the fourth decade with gradual decline to the sixth decade of life. The dominant arm was stronger in most of the tested groups. The torque profiles of the rotator cuff muscles in men at all ages were significantly higher than that in women.ConclusionsWe found previously unrecognised variations of rotator cuff muscles’ isometric strength according to age, gender and dominancy in a normal population. The presented data may serve as a basis for the future studies for identification of the abnormal patterns of muscle isometric strength in patients with pathology of the rotator cuff muscles. Cite this article: Bone Joint Res 2013;2:214–19.
Cardiovascular Disease Risk Prediction in Women: Is There a Role for Novel Biomarkers?
Authors: Paynter Nina P , Everett Brendan M , Cook Nancy R 
Published: October 2013

Abstract

BACKGROUND
Risk prediction is an integral part of the current US guidelines for cardiovascular disease in women. Although current risk prediction algorithms exist to identify women at increased 10-year risk of cardiovascular disease (CVD), clinicians and researchers have been interested in developing novel biomarkers that might improve predictive accuracy further. These biomarkers have led to important insights into the pathophysiology of CVD, but results for their ability to improve prediction or guide preventive therapy have been mixed. The incidence of CVD is lower in women than men, and the effects of a number of traditional biomarkers on CVD risk differ in women compared to men. Both of these factors influence the ability to accurately predict CVD risk.

CONTENT
We review the distinctive aspects of CVD risk prediction in women, discuss the statistical challenges to improved risk prediction, and discuss a number of biomarkers in varying stages of development with a range of performance in prediction.

SUMMARY
A variety of biomarkers from different pathophysiologic pathways have been evaluated for improving CVD risk. While many have been incompletely studied or have not been shown to improve risk prediction in women, others, such as high-sensitivity troponin T, have shown promise in improving risk prediction. Increasing inclusion of women in CVD studies will be crucial to providing opportunities to evaluate future biomarkers.
Practices of un-disciplining: Notes on the interface of dance and moving image in performance
Authors: Harrington Chrissie , Sharma Aparna 
Published: October 2013

Abstract
This article articulates a series of creative practices in which ‘un-disciplining’ becomes central to making inter-disciplinary Dance-Moving Image (Dance-MI) performance. In this context Dance-MI performance implies the discourses between the live body and moving image within a performance whole. Motivating questions are: what sorts of interface processes could be devised and what would happen as a result? The integration of theory and practice is central to our interrogations and inspires movement, MI and sound materials. The article dwells on the processes by which movement and MI materials are generated and placed in dialogue with each other, and the complex potentials of those relationships. Practices recognize and build upon the specificities, overlaps and disparities between both Dance and MI, catapulting each form out of its determined disciplinary confine into spaces where sharing, exposing and recreating inspire new choreographies and thus new experiences for maker, performer and viewer. We articulate stilling, connecting and sensing as key concepts that emerge from our practice and are exemplified in selected works created by and with undergraduate students. The un-disciplining of Dance and MI as two movement-based forms liberate each to interface with the other and so create a new wholeness of experience that in turn privileges multiple perspectives over any singular vantage point. The article concludes by positing Dance-MI performance as experiential through a newness created by the co-presence and interaction between both forms – dance and moving image.
Reinventing the past: Rosemary Butcher encounters Allan Kaprow’s 18 Happenings in 6 Parts
Authors: Sachsenmaier Stefanie 
Published: October 2013

Abstract
This article discusses British choreographer Rosemary Butcher’s reinvention process in the context of Allan Kaprow’s 18 Happenings in 6 Parts. It argues that the connection to Kaprow’s first Happening from 1959 was meticulously processed by Butcher on a conceptual level, and that her 2010 reinvention, commissioned and presented at London’s Royal Festival Hall as part of ‘Move: Choreographing You’, was conceptually much closer aligned to Kaprow’s Happening than the actual live work might have suggested. Within this context the article enters established debates around choreographic adaptations and raises questions related to the ways archived performance work might be processed in order to produce ‘new’ signature practice, in Susan Melrose’s terms. It adopts Jean François Lyotard’s notion of the ‘dispositif’, or set-up, in order to explicate Butcher’s reinvention process.