bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secure attachment imagery facilitates help‐seeking and help‐acceptance in psychosis
Authors: Skrobinska Laura , Newman‐Taylor Katherine , Carnelley Katherine 
Published: June 2024

AbstractObjectivesPeople with psychosis delay accessing recommended treatments, resulting in poor healthcare outcomes and increased risk of relapse. Means of improving help‐seeking and help‐acceptance could reduce duration of untreated psychosis (DUP). This study examined the role of attachment style in help‐seeking and help‐acceptance in psychosis.DesignWe used an experimental design to test the effect of attachment imagery priming on help‐seeking and help‐acceptance intentions, in a sample with self‐reported psychosis. The independent variables were attachment imagery condition (secure vs. avoidant) and time (pre‐ vs. post‐prime). The dependent variables were state paranoia, help‐seeking intentions and help‐acceptance intentions.MethodsWe used an online research platform to recruit people with psychosis (n = 61). Participants were randomly allocated to the secure or avoidant attachment priming condition. All completed measures of state paranoia, help‐seeking, and help‐acceptance, before and after priming.ResultsIn comparison with the avoidant condition, secure attachment imagery resulted in reduced paranoia and increased help‐seeking and acceptance intentions, all with large effect sizes.ConclusionsThis is the first study to use an experimental design to assess the role of attachment style in help‐seeking and help‐acceptance in a clinical sample. Attachment style is causally linked to behavioural intentions that contribute to DUP. Clinicians should assess attachment and help‐seeking and acceptance, highlight these in formulation, and prioritise in treatment planning. Interventions that enhance help‐seeking and acceptance could improve access to recommended treatments and reduce DUP.
Comparative genomics of Xanthomonas cucurbitae isolates collected from Midwestern United States pumpkin fields
Authors: Rai Rikky , Vittore Kayla M. , Pasion Julius , Malvino Maria L. , Mason Jonathan D. , Liu Qiong , Sulley Salisu , Babadoost Mohammad , Catchen Julian M. , Hind Sarah R. 
Published: June 2024

AbstractBacterial spot disease of cucurbits, caused by Xanthomonas cucurbitae, is a major problem in cucurbit‐growing areas worldwide. In the Midwestern region of the United States, pumpkin and squash fields can have greater than 90% infected fruits, leading to high yield losses. While reference genomes are available for this bacterial species, the genetic diversity between different strains and populations is unknown. After performing restriction‐site associated DNA sequencing (RAD‐seq) analysis of X. cucurbitae isolates collected from the Midwestern region, we selected five representative isolates for further characterization, which included whole‐genome sequencing and in vitro enzyme and in planta virulence assays. Our results suggest that minimal genetic diversity exists between these isolates, and that the isolates have differential virulence on different cucurbit host plants. This study contributes to our understanding of X. cucurbitae population dynamics in the Midwestern region and may assist with developing additional management strategies for controlling bacterial spot disease of cucurbits.
Gender dynamics and marital bargaining in the Global South
Authors: Yu Jia 
Published: June 2024

AbstractBargaining between husband and wife is reflective of the power dynamics in marriage. Women's access to resources and power through bargaining is integral to their empowerment, particularly in the Global South, where more traditional patriarchal family cultures prevail. This review summarizes the key theories concerning marital bargaining and evaluates the recent developments in research on marital bargaining by exploring patterns, determinants, and consequences of bargaining over power and resources among couples in the Global South. Several future research directions are proposed: examining the long‐term implications of the Covid‐19 pandemic on women's agency, employing a more comparative approach, and navigating marital bargaining from a broader family context.
Identification of anther thermotolerance genes by the integration of linkage and association analysis in maize
Authors: Feng Yijian , Li Xinlong , Qin Yongtian , Li Yibo , Yang Zeyuan , Xiong Xuehang , Wan Jiong , Qiu Meng , Hou Qiuchan , Zhang Zhanhui , Guo Zhanyong , Zhang Xuehai , Niu Jishan , Zhou Qingqian , Tang Jihua , Fu Zhiyuan 
Published: June 2024

SUMMARYMaize is one of the world's most important staple crops, yet its production is increasingly threatened by the rising frequency of high‐temperature stress (HTS). To investigate the genetic basis of anther thermotolerance under field conditions, we performed linkage and association analysis to identify HTS response quantitative trait loci (QTL) using three recombinant inbred line (RIL) populations and an association panel containing 375 diverse maize inbred lines. These analyses resulted in the identification of 16 co‐located large QTL intervals. Among the 37 candidate genes identified in these QTL intervals, five have rice or Arabidopsis homologs known to influence pollen and filament development. Notably, one of the candidate genes, ZmDUP707, has been subject to selection pressure during breeding. Its expression is suppressed by HTS, leading to pollen abortion and barren seeds. We also identified several additional candidate genes potentially underly QTL previously reported by other researchers. Taken together, our results provide a pool of valuable candidate genes that could be employed by future breeding programs aiming at enhancing maize HTS tolerance.
The adaptive mechanisms of the marine diatom Thalassiosira weissflogii to long‐term high CO2 and warming
Authors: Zhou Yunyue , Wu Fenghuang , Wu Jiao , Overmans Sebastian , Ye Mengcheng , Xiao Mengting , Peng Baoyi , Xu Leyao , Huang Jiali , Lu Yucong , Wang Yipeng , Liang Shiman , Zhang Hao , Liang Xiao , Zhong Zhirong , Liu Haobin , Ruan Zuoxi , Xia Jianrong , Jin Peng 
Published: June 2024

SUMMARYWhile it is known that increased dissolved CO2 concentrations and rising sea surface temperature (ocean warming) can act interactively on marine phytoplankton, the ultimate molecular mechanisms underlying this interaction on a long‐term evolutionary scale are relatively unexplored. Here, we performed transcriptomics and quantitative metabolomics analyses, along with a physiological trait analysis, on the marine diatom Thalassiosira weissflogii adapted for approximately 3.5 years to warming and/or high CO2 conditions. We show that long‐term warming has more pronounced impacts than elevated CO2 on gene expression, resulting in a greater number of differentially expressed genes (DEGs). The largest number of DEGs was observed in populations adapted to warming + high CO2, indicating a potential synergistic interaction between these factors. We further identified the metabolic pathways in which the DEGs function and the metabolites with significantly changed abundances. We found that ribosome biosynthesis‐related pathways were upregulated to meet the increased material and energy demands after warming or warming in combination with high CO2. This resulted in the upregulation of energy metabolism pathways such as glycolysis, photorespiration, the tricarboxylic acid cycle, and the oxidative pentose phosphate pathway, as well as the associated metabolites. These metabolic changes help compensate for reduced photochemical efficiency and photosynthesis. Our study emphasizes that the upregulation of ribosome biosynthesis plays an essential role in facilitating the adaptation of phytoplankton to global ocean changes and elucidates the interactive effects of warming and high CO2 on the adaptation of marine phytoplankton in the context of global change.
Racial/ethnic disparities in chronic wounds: Perspectives on linking upstream factors to health outcomes
Authors: Cavalcante‐Silva Jacqueline , Fantuzzi Giamila , Minshall Richard , Wu Stephanie , Oddo Vanessa M. , Koh Timothy J. 
Published: June 2024

AbstractThis review explores the complex relationship between social determinants of health and the biology of chronic wounds associated with diabetes mellitus, with an emphasis on racial/ethnic disparities. Chronic wounds pose significant healthcare challenges, often leading to severe complications for millions of people in the United States, and disproportionally affect African American, Hispanic, and Native American individuals. Social determinants of health, including economic stability, access to healthcare, education, and environmental conditions, likely influence stress, weathering, and nutrition, collectively shaping vulnerability to chronic diseases, such as obesity and DM, and an elevated risk of chronic wounds and subsequent lower extremity amputations. Here, we review these issues and discuss the urgent need for further research focusing on understanding the mechanisms underlying racial/ethnic disparities in chronic wounds, particularly social deprivation, weathering, and nutrition, to inform interventions to address these disparities.
A strong FKG inequality for multiple events
Authors: Gladkov Nikita 
Published: June 2024

AbstractWe extend the Fortuin–Kasteleyn–Ginibre (FKG) inequality to cover multiple events with equal pairwise intersections. We then apply this inequality to resolve Kahn's question on positive associated measures, as well as prove new inequalities concerning random graphs and probabilities of connection in Bernoulli percolation.
Data from Red Blood Cell Polyunsaturated Fatty Acids and Mortality Following Breast Cancer
Authors: Parada Humberto , Wu Tianying , Hoh Eunha , Rock Cheryl L. , Martinez Maria E. 
Published: July 2024

<div>AbstractBackground:<p>Intake of polyunsaturated fatty acids (PUFA) may affect mortality following breast cancer; however, epidemiological studies have relied on the self-reported assessment of PUFA intake. Herein, we examined the associations between red blood cell (RBC) PUFAs and mortality.</p>Methods:<p>This nested case–control study included 1,104 women from the Women’s Healthy Eating and Living study, a multistate randomized controlled trial. Cases (<i>n</i> = 290) comprised women who died from 1995 to 2006. Matched controls (<i>n</i> = 814) comprised women who were alive at the end of follow-up. PUFAs were measured in baseline RBC samples and included four ω-3 and seven ω-6 PUFAs. We examined each PUFA individually and principal components factor analysis (PCFA)-derived scores in association with all-cause mortality (ACM) and breast cancer–specific mortality (BCM) using conditional logistic regression to estimate ORs and 95% confidence intervals (CIs).</p>Results:<p>In fully adjusted models, ACM ORs were elevated among women with PUFAs above the median (>median) versus at the median or below (≤median) for α-linolenic acid (ALA; OR = 1.63, 95% CI, 1.18–2.24) and linolenic acid (LA; OR = 1.56, 95% CI, 1.16–2.09). BCM ORs were elevated for ALA (OR = 1.83, 95% CI, 1.27–2.63), LA (OR = 1.70, 95% CI, 1.23–2.37), and γ-linolenic acid (GLA; OR = 1.50, 95% CI, 1.04–2.16). PCFA Factor 1 (arachidonic acid–adrenic acid–docosapentaenoic acid) scores above the median (vs. ≤median) were associated with lower odds of ACM (OR = 0.71, 95% CI, 0.52–0.97) and BCM (OR = 0.69, 95% CI, 0.49–0.97). PCFA Factor 4 (ALA/GLA) scores above the median (vs. ≤median) were associated with increased odds of BCM (OR = 1.47, 95% CI, 1.04–2.09).</p>Conclusions:<p>RBC ALA, LA, and GLA may be prognostic indicators among breast cancer survivors.</p>Impact:<p>These results are important for understanding the associations between a biomarker of PUFA intake and mortality among BC survivors.</p></div>
Table S3 from Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy
Authors: Dias Matheus Henrique , Friskes Anoek , Wang Siying , Fernandes Neto Joao M. , van Gemert Frank , Mourragui Soufiane , Papagianni Chrysa , Kuiken Hendrik J. , Mainardi Sara , Alvarez-Villanueva Daniel , Lieftink Cor , Morris Ben , Dekker Anna , van Dijk Emma , Wilms Lieke H.S. , da Silva Marcelo S. , Jansen Robin A. , Mulero-Sánchez Antonio , Malzer Elke , Vidal August , Santos Cristina , Salazar Ramón , Wailemann Rosangela A.M. , Torres Thompson E.P. , De Conti Giulia , Raaijmakers Jonne A. , Snaebjornsson Petur , Yuan Shengxian , Qin Wenxin , Kovach John S. , Armelin Hugo A. , te Riele Hein , van Oudenaarden Alexander , Jin Haojie , Beijersbergen Roderick L. , Villanueva Alberto , Medema Rene H. , Bernards Rene 
Published: July 2024

<p>Supplementary table 3: Full list of genes whose knockout attenuated LB-100 toxicity in SW-480 cells in the CRISPR-KO screen FDR smaller or equal to 0.25 and log2 fold change greater or equal to 1 in treated/untreated comparison were criteria for hit selection.</p>
The History of Chromosomal Instability in Genome-Doubled Tumors
Authors: Baker Toby M. , Lai Siqi , Lynch Andrew R. , Lesluyes Tom , Yan Haixi , Ogilvie Huw A. , Verfaillie Annelien , Dentro Stefan , Bowes Amy L. , Pillay Nischalan , Flanagan Adrienne M. , Swanton Charles , Spellman Paul T. , Tarabichi Maxime , Van Loo Peter 
Published: June 2024

Abstract
Tumors frequently display high chromosomal instability and contain multiple copies of genomic regions. Here, we describe Gain Route Identification and Timing In Cancer (GRITIC), a generic method for timing genomic gains leading to complex copy number states, using single-sample bulk whole-genome sequencing data. By applying GRITIC to 6,091 tumors, we found that non-parsimonious evolution is frequent in the formation of complex copy number states in genome-doubled tumors. We measured chromosomal instability before and after genome duplication in human tumors and found that late genome doubling was followed by an increase in the rate of copy number gain. Copy number gains often accumulate as punctuated bursts, commonly after genome doubling. We infer that genome duplications typically affect the landscape of copy number losses, while only minimally impacting copy number gains. In summary, GRITIC is a novel copy number gain timing framework that permits the analysis of copy number evolution in chromosomally unstable tumors.
Significance: Complex genomic gains are associated with whole-genome duplications, which are frequent across tumors, span a large fraction of their genomes, and are linked to poorer outcomes. GRITIC infers when these gains occur during tumor development, which will help to identify the genetic events that drive tumor evolution.
See related commentary by Taylor, p. 1766
The Influence of Cash Ratio, Net Profit Margin, and Company Size on Dividend Policy
Authors: Dea Anggraini  , Utami Ranti , Afriyadi  , Novica Indriaty  , Tommy Munaf  
Published: July 2024

The purpose of this study was to determine the effect of cash ratio, net profit margin and company size on dividend policy in consumer non-cyclicals companies listed on the Indonesia Stock Exchange in 2018-2022. The research method used in this research is quantitative. The population in this study were 58 main board consumer non-cyclicals companies listed on the Indonesia Stock Exchange for the period 2018-2022. The sampling technique used in this study was purposive sampling. So that the sample obtained was 21 consumer non-cyclicals companies listed on the IDX for the 2018-2022 period. The results showed that partially cash ratio and net profit margin had no effect on dividend policy. Meanwhile, company size partially has a significant effect on dividend policy. It can be concluded that cash ratio, net profit margin and company size have an effect on dividend policy. And the Adjusted R-Squared value is 0.736174, which means that the dividend policy is influenced by the Cash Ratio, Net Profit Margin and Company Size by 73.62% and 26.38% is influenced by other variables not examined in this study.
Enhanced wound healing potential of arabincoside B isolated from Caralluma Arabica in rat model; a possible dressing in veterinary practice
Authors: Ali Mawada Mohamed , Al-Mokaddem Asmaa Khairy , Abdel-Sattar Essam , El-Shiekh Riham A. , Farag Michael M. , Aljuaydi Samira H. , Shaheed Iman B. 
Published: July 2024

Abstract
Background
Wound management is a critical procedure in veterinary practice. A wound is an injury that requires the body’s cells’ alignment to break down due to external assault, such as trauma, burns, accidents, and diseases. Re-epithelization, extracellular matrix deposition, especially collagen, inflammatory cell infiltration, and development of new blood capillaries are the four features that are used to evaluate the healing process. Using a natural extract for wound management is preferred to avoid the side effects of synthetic drugs. The current study aimed to assess the effect of major pregnane glycoside arabincoside B (AR-B) isolated from Caralluma arabica (C. arabica) for the wound healing process.

Method
AR-B was loaded on a gel for wound application. Rats were randomly distributed into six groups: normal, positive control (PC), MEBO®, AR-B 0.5%, AR-B 1%, and AR-B 1.5%, to be 6 animals in each group. Wounds were initiated under anesthesia with a 1 cm diameter tissue needle, and treatments were applied daily for 14 days. The collected samples were tested for SOD, NO, and MDA. Gene expression of VEGF and Caspase-3. Histopathological evaluation was performed at two-time intervals (7 and 14 days), and immunohistochemistry was done to evaluate α -SMA, TGF-β, and TNF-α.

Result
It was found that AR-B treatment enhanced the wound healing process. AR-B treated groups showed reduced MDA and NO in tissue, and SOD activity was increased. Re-epithelization and extracellular matrix deposition were significantly improved, which was confirmed by the increase in TGF-β and α -SMA as well as increased collagen deposition. TNF-α was reduced, which indicated the subsiding of inflammation. VEGF and Caspase-3 expression were reduced.

Conclusion
Our findings confirmed the efficiency of AR-B in enhancing the process of wound healing and its potential use as a topical wound dressing in veterinary practice.
A Phase I/II Trial of Sapanisertib in Advanced Anaplastic and Radioiodine Refractory Differentiated Thyroid Carcinoma
Authors: Sehgal Kartik , Serritella Anthony , Liu Mofei , ONeill Anne , Nangia Chaitali , Pappa Theodora , Demeure Michael J , Worden Francis P , Haddad Robert I , Lorch Jochen 
Published: June 2024

Abstract

Background
There are limited therapeutic options for patients with recurrent/metastatic anaplastic thyroid carcinoma (ATC) and radioiodine refractory (RAIR) differentiated thyroid carcinoma (DTC) refractory to multikinase inhibitors. This multicenter trial evaluated sapanisertib, a next-generation oral kinase inhibitor of mTOR complexes 1/2, in ATC and RAIR DTC.

Methods
A safety run-in phase I was followed by nonrandomized phase II trial in ATC, with an exploratory cohort in RAIR DTC. The primary endpoint was the proportion of patients with ATC who were without disease progression at 4 months. Safety and survival outcomes were key secondary endpoints.

Results
Forty-six patients (20 ATC, 26 DTC) were enrolled including 40 (18 ATC, 22 DTC) who received recommended phase II dose of 5 mg daily. Eleven percent [2/18, 95% confidence interval (CI): 1.4-34.7%] of patients with ATC were progression-free at 4 months; 22.2% (4/18) had stable disease as best response. Enrollment in the ATC cohort stopped early with 18 patients out of the proposed 23 due to overall futility. One confirmed partial response (4.5%, 1/22) occurred in RAIR DTC, with stable disease in 63.6% (14/22) patients. Median progression-free survival was 1.6 (95% CI: 0.9-2.8) months and 7.8 (2.0–not reached) months in ATC and DTC, respectively. Grade 3 treatment-related adverse events occurred in 30% of patients who received the phase II dose, with the most common being anorexia, nausea, diarrhea, fatigue, skin rash, and hyperglycemia. Genomic alterations in the PI3K/AKT/mTOR pathway were not associated with response or progression-free survival.

Conclusion
Sapanisertib monotherapy did not meet the primary endpoint of this trial (proportion progression-free at 4 months) in ATC and did not show clinically meaningful activity. Clinical trials with alternative therapeutic strategies are needed.
Omega-3 Polyunsaturated Fatty Acids And Adipose Tissue Inflammation: Longitudinal Analysis in the PROMISE Cohort
Authors: Chon Ji-Eun , Semnani-Azad Zhila , Lai Kira Zhi Hua , Connelly Phillip W , Retnakaran Ravi , Harris Stewart B , Metherel Adam H , Jenkins David J A , Bazinet Richard P , Hanley Anthony J 
Published: June 2024

Abstract

Objectives
Although preclinical studies have shown a beneficial impact of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) on adipose tissue (AT) inflammation, the current literature from human studies is limited. Therefore, we aimed to evaluate the longitudinal associations of circulating levels of n-3 PUFAs with biomarkers of AT inflammation.

Methods
Longitudinal data from participants in the PROMISE cohort (n = 474) were used. AT inflammation was measured using circulating biomarkers at baseline and up to 2 follow-up visits. n-3 PUFAs were measured at baseline in 4 serum lipid fractions. Generalized estimating equations analyses evaluated longitudinal associations between n-3 PUFAs and AT inflammation, adjusting for covariates.

Results
Fully adjusted generalized estimating equation models indicated that higher baseline proportions of eicosapentaenoic acid, n-3 docosapentaenoic acid, and docosahexaenoic acid in total serum were significantly inversely associated with longitudinal change in soluble CD163 (all P &lt; .05). A significant positive association of n-3 docosapentaenoic acid and docosahexaenoic acid with longitudinal change in adiponectin (P &lt; .05) was also observed. Generally consistent associations were observed between n-3 PUFAs and soluble CD163 and adiponectin in the four lipid fractions.

Conclusion
These findings will add to the limited evidence on the potential role n-3 PUFAs have in the prevention and management of AT inflammation in humans and may help inform future interventions targeting chronic inflammation at the level of AT.