bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of levomilnacipran extended-release in major depressive disorder: pooled analysis of 5 double-blind, placebo-controlled trials
Authors: Montgomery Stuart A. , Gommoll Carl P. , Chen Changzheng , Greenberg William M. 
Published: June 2014

Introduction/ObjectivePost hoc analyses were conducted to evaluate the efficacy of levomilnacipran extended-release (ER) in subgroups of patients with major depressive disorder (MDD).MethodsData were pooled from 5 completed Phase II/III studies. Patients were categorized by sex, age, MDD duration, recurrence of MDD, current episode duration, number of prior episodes, and baseline Montgomery–Åsberg Depression Rating Scale (MADRS) score. Efficacy was evaluated by MADRS least squares (LS) mean change from baseline, response (MADRS improvement ≥50%), and remission (MADRS ≤10).ResultsIn the pooled population, treatment with levomilnacipran ER versus placebo resulted in greater improvement in MADRS score (−15.8 versus −12.9; LS mean difference, −2.9; P < .001) and higher response rates (44.7% versus 34.5%; P < .001). Comparable treatment effects were found in most subgroups. Remission rates in the overall population were higher for levomilnacipran ER versus placebo (27.7% versus 21.5%; P < .05); notably high remission rates were seen in patients with baseline MADRS score < 30 (48.8% versus 28.9%; P < .001).DiscussionClinically meaningful improvements in depressive symptoms were found across subgroups, including statistically significant outcomes for both response and remission.ConclusionLevomilnacipran ER was efficacious across a wide range of MDD patients, including men and women, ages 18–78, with varying histories and symptom severity.
MEMBRANE-COUPLED GRAVITY WAVE SCATTERING BY A VERTICAL BARRIER WITH A GAP
Authors: MANAM S. R. , KALIGATLA R. B. 
Published: June 2014

AbstractWe study the reflection of membrane-coupled gravity waves in deep water against a vertical barrier with a gap. A floating membrane is attached on both sides of the barrier. The associated mixed boundary value problem, which is not particularly well posed, is analysed. We utilize an orthogonal mode-coupling relation to reduce the problem to solving a set of dual integral equations with trigonometric kernel. We solve these by using a weakly singular integral equation. The reflection coefficient is determined explicitly, while having freedom to clamp the membrane with a spring of a certain stiffness on only one side of the vertical barrier. The physical problem is of capillary–gravity wave scattering by a vertical barrier with a gap, when the membrane density is neglected. In this case, the reflection coefficient is known up to an undetermined edge slope on either side of the barrier. The scattering quantity is computed and presented graphically against a wave parameter for different values of nondimensional parameters pertaining to the structures involved in the problem.
NEW DEVELOPMENT OF NONRIGID REGISTRATION
Authors: HSIAO HSI-YUE , HSIEH CHIH-YAO , CHEN XI , GONG YONGYI , LUO XIAONAN , LIAO GUOJUN 
Published: June 2014

AbstractWe propose a new nonrigid registration algorithm which is based on the optimal control approach. In our previously proposed methods, the Jacobian determinant and the curl vector were used as control functions. In this algorithm, we use a new set of control functions. A main advantage of using the new controls is that the positivity and normalization of the Jacobian determinant are satisfied automatically. Numerical results on large deformation brain images are provided to show the accuracy and efficiency of the algorithm.
Hospice palliative care volunteers: The benefits for patients, family caregivers, and the volunteers
Authors: Claxton-Oldfield Stephen 
Published: June 2014

AbstractObjective:Terminally ill patients and family caregivers can benefit greatly from the support and care provided by trained hospice palliative care volunteers. The benefits of doing this kind of volunteer work also extend to the volunteers themselves, who often say they receive more than they give from the patients/families they are “privileged” to be with. The purpose of this article is to demonstrate how hospice palliative care volunteerism benefits both the patients and families who utilize this service as well as the volunteers.Method:A review of studies demonstrating how terminally ill patients, and especially family caregivers, can benefit from the use of hospice palliative care volunteers and how the volunteers themselves benefit from their experiences.Results:Terminally ill patients and families receive many benefits from using the services of hospice palliative care volunteers, including emotional support, companionship, and practical assistance (e.g., respite or breaks from caregiving). Volunteering in hospice palliative care also provides many benefits for the volunteers, including being able to make a difference in the lives of others, personal growth, and greater appreciation of what is really important in life.Significance of results:More needs to be done to promote the value of hospice palliative care volunteers to those who can really benefit from their support and care (i.e., patients and their families) as well as to help people recognize the potential rewards of being a hospice palliative care volunteer. It is a win–win situation.
High density GaN/AlN quantum dots for deep UV LED with high quantum efficiency and temperature stability
Authors: Yang Weihuang , Li Jinchai , Zhang Yong , Huang Po-Kai , Lu Tien-Chang , Kuo Hao-Chung , Li Shuping , Yang Xu , Chen Hangyang , Liu Dayi , Kang Junyong 
Published: June 2014

AbstractHigh internal efficiency and high temperature stability ultraviolet (UV) light-emitting diodes (LEDs) at 308 nm were achieved using high density (2.5 × 109 cm−2) GaN/AlN quantum dots (QDs) grown by MOVPE. Photoluminescence shows the characteristic behaviors of QDs: nearly constant linewidth and emission energy and linear dependence of the intensity with varying excitation power. More significantly, the radiative recombination was found to dominant from 15 to 300 K, with a high internal quantum efficiency of 62% even at room temperature.
Gremlin-2 is a BMP antagonist that is regulated by the circadian clock
Authors: Yeung Ching-Yan Chloé , Gossan Nicole , Lu Yinhui , Hughes Alun , Hensman James J. , Bayer Monika L. , Kjær Michael , Kadler Karl E. , Meng Qing-Jun 
Published: June 2014

AbstractTendons are prominent members of the family of fibrous connective tissues (FCTs), which collectively are the most abundant tissues in vertebrates and have crucial roles in transmitting mechanical force and linking organs. Tendon diseases are among the most common arthropathy disorders; thus knowledge of tendon gene regulation is essential for a complete understanding of FCT biology. Here we show autonomous circadian rhythms in mouse tendon and primary human tenocytes, controlled by an intrinsic molecular circadian clock. Time-series microarrays identified the first circadian transcriptome of murine tendon, revealing that 4.6% of the transcripts (745 genes) are expressed in a circadian manner. One of these genes was Grem2, which oscillated in antiphase to BMP signaling. Moreover, recombinant human Gremlin-2 blocked BMP2-induced phosphorylation of Smad1/5 and osteogenic differentiation of human tenocytes in vitro. We observed dampened Grem2 expression, deregulated BMP signaling and spontaneously calcifying tendons in young CLOCKΔ19 arrhythmic mice and aged wild-type mice. Thus, disruption of circadian control, through mutations or aging, of Grem2/BMP signaling becomes a new focus for the study of calcific tendinopathy, which affects 1-in-5 people over the age of 50 years.
TM4SF5 suppression disturbs integrin α5-related signalling and muscle development in zebrafish
Authors: Choi Yoon-Ju , Kim Hyun Ho , Kim Jeong-gyun , Kim Hye-Jin , Kang Minkyung , Lee Mi-Sook , Ryu Jihye , Song Haeng Eun , Nam Seo Hee , Lee Doohyung , Kim Kyu-Won , Lee Jung Weon 
Published: June 2014

TM4SF5 (transmembrane 4 L six family member 5) is involved in EMT (epithelial–mesenchymal transition) for liver fibrosis and cancer metastasis; however, the function(s) of TM4SF5 during embryogenesis remains unknown. In the present study the effects of TM4SF5 on embryogenesis of zebrafish were investigated. tm4sf5 mRNA was expressed in the posterior somites during somitogenesis and in whole myotome 1 dpf (day post-fertilization). tm4sf5 suppression impaired development of the trunk with aberrant morphology of muscle fibres and altered expression of integrin α5. The arrangement and adhesion of muscle cells were abnormally disorganized in tm4sf5 morphants with reduced muscle fibre masses, where integrin α5-related signalling molecules, including fibronectin, FAK (focal adhesion kinase), vinculin and actin were aberrantly localized, compared with those in control fish. Aberrant muscle developments in tm4sf5 morphants were recovered by additional tm4sf5 or integrin α5 mRNA injection. Such a role for TM4SF5 was observed in the differentiation of C2C12 mouse myoblast cells to multinuclear muscle cells. Taken together, the results show that TM4SF5 controls muscle differentiation via co-operation with integrin α5-related signalling.
Mechanisms of Change in Adolescent Substance Use Treatment: How Does Treatment Work?
Authors: Black Jessica J. , Chung Tammy 
Published: June 2014

Background Adolescent substance use treatment outcome research generally shows small to moderate effects in reducing substance use, with no specific “brand” of treatment emerging as clearly superior to any other, and treatment gains that fade over time. The relatively weak and temporary effects of treatment call for improving the potency and durability of intervention effects. In response to this call, this critical narrative review summarizes research on mechanisms of change for both adults and adolescents in substance use treatment, with a particular focus on reviewing what is known regarding “how” adolescent substance use treatment works. Methods A comprehensive review of the adolescent (aged 11–18) substance use treatment literature was conducted to identify empirical studies that examined mediators of intervention effects. Relevant databases (e.g., PsychINFO, MEDLINE) were searched using key words (e.g., “mediator”), and relevant articles from reference sections of identified studies and review papers were considered. Results Studies of mechanisms of psychotherapy change are rare in the adult, and particularly adolescent, substance use treatment outcome literature. The 4 adolescent studies that examined substance use treatment mechanisms found that positive social support, motivation to abstain, and positive parenting behaviors mediated treatment effects. To date, research has not supported therapy-specific mechanisms of change, finding instead that “common” processes of change largely account for improvements in outcome across distinct “brands” of treatment. Conclusions The lack of empirical support for treatment-specific mechanisms of change may be due to the need for greater precision in defining and measuring treatment-specific causal chains. Future directions include neuroscience approaches to examining changes in brain functioning that are associated with treatment response and recovery and examining mechanisms in adaptive treatment designs, which can accommodate individual differences in targets for intervention and response to treatment.
A fossilOsmundafrom the Jurassic of Sweden—reconciling molecular and fossil evidence in the phylogeny of Osmundaceae
Authors: Bomfleur Benjamin , Grimm Guido W. , McLoughlin Stephen 
Published: June 2014

ABSTRACTThe systematic classification of Osmundaceae has long remained controversial. Recent molecular data indicate thatOsmundais paraphyletic, and needs to be separated intoOsmundastrumandOsmunda s. str. Here we describe an exquisitely preserved JurassicOsmundarhizome (O. pulchellasp. nov.) that combines diagnostic features ofOsmundastrumandOsmunda, calling molecular evidence for paraphyly into question. We assembled a new morphological matrix based on rhizome anatomy, and used network analyses to establish phylogenetic relationships between fossil and extant members of modern Osmundaceae. We re-analysed the original molecular data to evaluate root-placement support. Finally, we integrated morphological and molecular data-sets using the evolutionary placement algorithm.Osmunda pulchellaand five additional, newly identified JurassicOsmundaspecies show anatomical character suites intermediate betweenOsmundastrumandOsmunda.Molecular evidence for paraphyly is ambiguous: a previously unrecognized signal from spacer sequences favours an alternative root placement that would resolveOsmunda s.l.as monophyletic. Our evolutionary placement analysis identifies fossil species as ancestral members of modern genera and subgenera. Altogether, the seemingly conflicting evidence from morphological, anatomical, molecular, and palaeontological data can be elegantly reconciled under the assumption thatOsmundais indeed monophyletic; the recently proposed root-placement in Osmundaceae—based solely on molecular data—likely results from un- or misinformative out-group signals.
Origin and evolution of the self-organizing cytoskeleton in the network of eukaryotic organelles
Authors: Jékely Gáspár 
Published: June 2014

AbstractThe eukaryotic cytoskeleton evolved from prokaryotic cytomotive filaments. Prokaryotic filament systems show bewildering structural and dynamic complexity, and in many aspects prefigure the self-organizing properties of the eukaryotic cytoskeleton. Here I compare the dynamic properties of the prokaryotic and eukaryotic cytoskeleton, and discuss how these relate to function and the evolution of organellar networks. The evolution of new aspects of filament dynamics in eukaryotes, including severing and branching, and the advent of molecular motors converted the eukaryotic cytoskeleton into a self-organizing ‘active gel’, the dynamics of which can only be described with computational models. Advances in modeling and comparative genomics hold promise of a better understanding of the evolution of the self-organizing cytoskeleton in early eukaryotes, and its role in the evolution of novel eukaryotic functions, such as amoeboid motility, mitosis, and ciliary swimming.
Power analysis of artificial selection experiments using efficient whole genome simulation of quantitative traits
Authors: Kessner Darren , Novembre John 
Published: June 2014

AbstractEvolve and resequence studies combine artificial selection experiments with massively parallel sequencing technology to study the genetic basis for complex traits. In these experiments, individuals are selected for extreme values of a trait, causing alleles at quantitative trait loci (QTLs) to increase or decrease in frequency in the experimental population. We present a new analysis of the power of artificial selection experiments to detect and localize quantitative trait loci. This analysis uses a simulation framework that explicitly models whole genomes of individuals, quantitative traits, and selection based on individual trait values. We find that explicitly modeling QTL provides produces qualitatively different insights than considering independent loci with constant selection coefficients. Specifically, we observe how interference between QTLs under selection impacts the trajectories and lengthens the fixation times of selected alleles. We also show that a substantial portion of the genetic variance of the trait (50–100%) can be explained by detected QTLs in as little as 20 generations of selection, depending on the trait architecture and experimental design. Furthermore, we show that power depends crucially on the opportunity for recombination during the experiment. Finally, we show that an increase in power is obtained by leveraging founder haplotype information to obtain allele frequency estimates.
Complete plastid genome assembly of invasive plant,Centaurea diffusa
Authors: Turner Kathryn G. , Grassa Christopher J. 
Published: June 2014

AbstractNew genomic tools are needed to elucidate the evolution of invasive, non-model organisms. Here we present the completed plastome assembly for the problematic invasive weed,Centaurea diffusa. This new tool represents a significant contribution to future studies of the ecological genomics of invasive plants, particularly this weedy genus, and studies of the Asteraceae in general.
Simultaneous estimation of transcript abundances and transcript specific fragment distributions of RNA-Seq data with the Mix2model
Authors: Tuerk Andreas , Wiktorin Gregor 
Published: June 2014

AbstractQuantification of RNA transcripts with RNA-Seq is inaccurate due to positional fragmentation bias, which is not represented appropriately by current statistical models of RNA-Seq data. Another, less investigated, source of error is the inaccuracy of transcript start and end annotations.This article introduces the Mix2(rd. “mixquare”) model, which uses a mixture of probability distributions to model the transcript specific positional fragment bias. The parameters of the Mix2model can be efficiently trained with the EM algorithm and are tied between similar transcripts. Transcript specific shift and scale parameters allow the Mix2model to automatically correct inaccurate transcript start and end annotations. Experiments are conducted on synthetic data covering 7 genes of different complexity, 4 types of fragment bias and correct as well as incorrect transcript start and end annotations. Abundance estimates obtained by Cufflinks 2.2.0, PennSeq and the Mix2model show superior performance of the Mix2model in the vast majority of test conditions.The Mix2software is available athttp://www.lexogen.com/fileadmin/uploads/bioinfo/mix2model.tgz, subject to the enclosed license.Additional experimental data are available in the supplement.
The relationship between motivation to work and workers’ pay flexibility
Authors: Stynen Dave , Forrier Anneleen , Sels Luc 
Published: June 2014

Purpose– The purpose of this paper is to explore the role of motivation to work in explaining workers’ pay flexibility – as measured by their reservation wage ratio – across the lifespan. This is important since pay inflexibility may undermine mature age workers’ retention at the workforce.Design/methodology/approach– Relying on self-determination theory the paper broadens the role of “motivation to work” from the overall work valence an individual attaches to work to the underlying work values (i.e. the perceived value of work for its intrinsic vs extrinsic outcomes) and work motives (i.e. the underlying autonomous vs controlled reasons regulating one's work participation). The authors conducted hierarchical linear regression analyses on a sample of 1,577 Belgian workers to explore how individuals’ work values and work motives, in addition to work valence, shape workers’ reservation wage ratios across the lifespan.Findings– Results indicate that work valence and holding relative intrinsic work values and relative autonomous work motives are associated with lower reservation wage ratios. Finally, age moderates all three relationships. Whereas the negative impact of work valence and relative autonomous work motives is stronger at older age, the negative impact of relative intrinsic work values is stronger at younger age.Research limitations/implications– Motivational predictors are differently related to reservation wage ratios across the lifespan.Practical implications– By fostering overall work valence and autonomous work motivation practitioners can exert influence on mature age workers’ pay flexibility.Originality/value– This study extends prior research on pay flexibility by focussing on the content of motivation to work (i.e. work values, work motives) and its role across the lifespan.
An integrative model of work/family interface for Chinese employees
Authors: Lu Luo , Chang Yu-Yueh 
Published: June 2014

Purpose– The purpose of this paper is to examine the mediating roles of four aspects of work and family interface (WFI: work-to-family conflict, WFC; family-to-work conflict, FWC; work-to-family enrichment, WFE; and family-to-work enrichment, FWE) in a Chinese context in Taiwan. Included in the integral model are demands and resources from the work and family domains as antecedents, and role satisfaction and burnout as consequences.Design/methodology/approach– Structured questionnaires were used to collect data from 499 full-time working Chinese parents in Taiwan.Findings– Structural equation modeling results showed that antecedents had cross-domain and within-domain effects on all aspects of the WFI; and conflict and enrichment also had cross-domain and within-domain effects on job satisfaction and family satisfaction, while influences from the work domain (WFC and WFE) had a significant impact on burnout. Overall, the partial mediation model was supported, showing that antecedent variables having both indirect (through the WFI variables) as well as direct relationships with the outcome variables.Originality/value– This is the first study testing a comprehensive model of the whole loop of antecedents-WFI-consequences with a non-Western sample. One unique contribution of the study is that the authors extended Western-based resources theories to Chinese employees, confirming that all four aspects of the WFI are important mediators linking up antecedents with consequences from both the work and family domains. Basing upon the findings, the authors suggests that both managers and employees should endeavor to break the destructive flow of conflict→dissatisfaction/burnout and to initiate the constructive flow of enrichment→satisfaction/free of burnout, by considering not only demands but also resources from both the work and family domains.
Segmenting consumer reactions to social network marketing
Authors: Campbell Colin , Ferraro Carla , Sands Sean 
Published: June 2014

Purpose
– The purpose of this paper is to understand how consumers may be segmented with respect to their reactions to social network marketing.

Design/methodology/approach
– Consumers are segmented on the basis of attitudes toward social network marketing and the association among psychological, economic, and socio-demographic covariates are explored using data from 883 consumers and latent-class analysis.

Findings
– A total of five segments are identified – Passive, Talkers, Hesitant, Active, and Averse – along with significant covariates, such as information search, convenience, entertainment, age and gender that predict membership.

Research limitations/implications
– Evidence was found of two segments that are highly impacted by social network marketing in terms of brand engagement, purchase intention and WOM referral intention. The most engaged – the Active – representing approximately 10 percent, is most open to interacting with brands in social networks, likely to make a purchase as a result of the campaign, and likely to spread WOM. The second group – Talkers – representing 28 percent, is also high on all outcomes, but not impacted as greatly in terms of purchase intentions.

Practical implications
– There is a sizable share of the market (38 percent) that can be positively impacted through social network marketing. This paper reinforces that it is problematic to collapse all users of social networks.

Originality/value
– The paper offers a more nuanced understanding of how consumers engage with social media by focusing on how consumers engage with social network marketing and by employing three segmentation bases: brand engagement, purchase intention, and WOM.