bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal relationship between diabetes‐specific emotional distress and follow‐up HbA1c in adults with Type 1 diabetes mellitus
Authors: Strandberg R. B. , Graue M. , Wentzel‐Larsen T. , Peyrot M. , Thordarson H. B. , Rokne B. 
Published: April 2015

AbstractAimTo examine whether diabetes‐specific emotional distress was related to follow‐up glycaemic control in adults with Type 1 diabetes mellitus.MethodsAdults with Type 1 diabetes mellitus completed the Diabetes Distress Scale and reported sociodemographic information when attending a clinical consultation at a university endocrinology unit. Blood samples to determine baseline HbA1c were taken during consultations. All respondents' HbA1c measurements registered from January 2009 to December 2011 were collected from medical records. The relationship between baseline diabetes‐specific emotional distress and HbA1c was examined with linear mixed‐effects models in 175 patients with complete data.ResultsAfter controlling for confounders, baseline diabetes‐specific emotional distress and glycaemic control were significantly associated (fixed‐effect coefficient 0.40, P < 0.001) and the regimen‐related distress subscale had the strongest association with glycaemic control (fixed‐effect coefficient 0.47, P < 0.001). The two‐item measure of diabetes‐specific distress had a weaker but still significant association with glycaemic control (fixed‐effect coefficient 0.31, P < 0.001). None of these relationships was significant after adjusting for the baseline HbA1c.ConclusionsPeople with elevated baseline diabetes‐specific emotional distress are at risk of prolonged suboptimum glycaemic control; therefore, elevated diabetes‐specific emotional distress, especially regimen‐related distress, might be an important marker for prolonged suboptimum glycaemic control, and might indicate a need for special attention regarding patient self‐management.
Impact of a half marathon on cellular immune system, pro‐inflammatory cytokine levels, and recovery behavior of breast cancer patients in the aftercare compared to healthy controls
Authors: Zimmer Philipp , Baumann Freerk T. , Bloch Wilhelm , Zopf Eva Maria , Schulz Saskia , Latsch Joachim , Schollmayer Friederike , Shimabukuro‐Vornhagen Alexander , von Bergwelt‐Baildon Michael , Schenk Alexander 
Published: April 2015

AbstractIntroductionExercise has beneficial effects on cancer prevention as well as on prognosis of patients with cancer. To optimize the outcomes of exercise programs, more knowledge about the underlying mechanisms is needed. This study investigates the short‐term effects of a half marathon on immune cell proportions, pro‐inflammatory cytokine levels, and recovery behavior of patients with breast cancer in the aftercare compared to healthy controls.MethodsNine patients with breast cancer in the aftercare and 9 healthy age‐matched controls participated in a half marathon. Blood samples were collected before, after, and 24 h after the run. Immune status was measured by flow cytometer analysis, while serum levels of the pro‐inflammatory cytokines TNF‐α, IL‐6, and MIF were assessed using ELISA. Recovery behavior was determined using an ADL monitor.ResultsBoth groups showed a similar recovery behavior and time courses in changes of granulocytes, monocytes, lymphocytes, and cytokine serum levels. Patients revealed increased proportions of cytotoxic and memory T cells, whereas helper and naïve T cells were decreased compared to healthy controls. Naïve and memory T‐cell proportions were not affected by the intervention.ConclusionsPatients with breast cancer in the aftercare and healthy subjects show a similarly recovery behavior and immune response to the intervention. The detected differences in T‐cell subsets need further investigation. Based on the results of the study, we hypothesize that immune cell subsets with known relevance in cancer were mobilized through the intervention. We confirm that the hypothesis of a midterm anti‐inflammatory effect of exercise is also valid for patients with breast cancer in the aftercare.
Structural asymmetry of the insula is linked to the lateralization of gesture and language
Authors: Biduła Szymon P. , Króliczak Gregory 
Published: April 2015

AbstractThe control of gesture is one of the most left‐lateralized functions, and the insular cortex is one of the most left‐biased structures in the human brain. Therefore, we investigated whether structural asymmetries of the insula are linked to the organization of functional activity during gesture planning. We reconstructed and parcellated the insular cortex of 27 participants. First, we tested 15 strongly left‐handed individuals because of a higher incidence of atypical organization of functions such as gesture and language in such a population. The inter‐hemispheric structural asymmetries were compared with the lateralization of activity for gesture in the supramarginal gyrus (the hotspot of signal increase regardless of the gesturing hand) and Broca's area (the hotspot of signal increase for language production). The more pronounced leftward structural asymmetries were accompanied by greater left‐hemisphere dominance for both of the studied functions. Conversely, an atypical, bilateral or rightward functional shift of gesture and language was accompanied by an attenuated leftward asymmetry of the insula. These significant relationships were driven primarily by differences in surface area. Subsequently, by adding 12 right‐handed individuals to these analyses we demonstrated that the observed significant associations are generalizable to the population. These results provide the first demonstration of the relationships between structural inter‐hemispheric differences of the insula and the cerebral specialization for gesture. They also corroborate the link between insular asymmetries and language lateralization. As such, these outcomes are relevant to the common cerebral specialization for gesture and language.
GRIN1 mutations cause encephalopathy with infantile‐onset epilepsy, and hyperkinetic and stereotyped movement disorders
Authors: Ohba Chihiro , Shiina Masaaki , Tohyama Jun , Haginoya Kazuhiro , Lerman‐Sagie Tally , Okamoto Nobuhiko , Blumkin Lubov , Lev Dorit , Mukaida Souichi , Nozaki Fumihito , Uematsu Mitsugu , Onuma Akira , Kodera Hirofumi , Nakashima Mitsuko , Tsurusaki Yoshinori , Miyake Noriko , Tanaka Fumiaki , Kato Mitsuhiro , Ogata Kazuhiro , Saitsu Hirotomo , Matsumoto Naomichi 
Published: April 2015

SummaryObjectiveRecently, de novo mutations in GRIN1 have been identified in patients with nonsyndromic intellectual disability and epileptic encephalopathy. Whole exome sequencing (WES) analysis of patients with genetically unsolved epileptic encephalopathies identified four patients with GRIN1 mutations, allowing us to investigate the phenotypic spectrum of GRIN1 mutations.MethodsEighty‐eight patients with unclassified early onset epileptic encephalopathies (EOEEs) with an age of onset <1 year were analyzed by WES. The effect of mutations on N‐methyl‐d‐aspartate (NMDA) receptors was examined by mapping altered amino acids onto three‐dimensional models.ResultsWe identified four de novo missense GRIN1 mutations in 4 of 88 patients with unclassified EOEEs. In these four patients, initial symptoms appeared within 3 months of birth, including hyperkinetic movements in two patients (2/4, 50%), and seizures in two patients (2/4, 50%). Involuntary movements, severe developmental delay, and intellectual disability were recognized in all four patients. In addition, abnormal eye movements resembling oculogyric crises and stereotypic hand movements were observed in two and three patients, respectively. All the four patients exhibited only nonspecific focal and diffuse epileptiform abnormality, and never showed suppression‐burst or hypsarrhythmia during infancy. A de novo mosaic mutation (c.1923G>A) with a mutant allele frequency of 16% (in DNA of blood leukocytes) was detected in one patient. Three mutations were located in the transmembrane domain (3/4, 75%), and one in the extracellular loop near transmembrane helix 1. All the mutations were predicted to impair the function of the NMDA receptor.SignificanceClinical features of de novo GRIN1 mutations include infantile involuntary movements, seizures, and hand stereotypies, suggesting that GRIN1 mutations cause encephalopathy resulting in seizures and movement disorders.
Status of invasive alien plants included in EPPO Lists in Turkey
Authors: Arslan Z. F. , Uludag A. , Uremis I. 
Published: April 2015

Turkey is one of the richest areas in the middle latitudes in terms of plant diversity. It has approximately 12 000 plant species and a great number of new species are being added each year. However, invasive alien species have not yet been fully considered in Turkey and only two plant species are in Turkey's quarantine list (Arceuthobium spp. and Eichhornia crassipes). EPPO is an intergovernmental organization responsible for cooperation in plant protection in the European and Mediterranean region and maintains the A1 and A2 Lists of pests recommended for regulation (A1 species are absent from the EPPO region, A2 species are present but of limited distribution), the List of Invasive Alien Plants, the Observation List of invasive alien plants and the Alert List. Eichhornia crassipes, Heracleum persicum, Heracleum sosnowskyi, Ludwigia peploides, Polygonum perfoliatum and Solanum elaeagnifolium are among the species which were recorded in Turkey and are included in the EPPO A2 List. Species recorded in the EPPO List of invasive alien plants which are present in Turkey are: Acroptilon repens, Ailanthus altissima, Ambrosia artemisiifolia (= A. elatior), Carpobrotus edulis, Cortaderia selloana, Cyperus esculentus, Paspalum distichum (= P. paspalodes), Oxalis pes‐caprae and Sicyos angulatus. Azolla filiculoides and Rhododendron ponticum are listed in the EPPO Observation List of Invasive alien plants and Miscanthus sinensis, listed in the EPPO Alert List, are also recorded in the Turkish flora.
Does Innovation Success Influence Social Interactions? An Experimental Test in House Sparrows
Authors: Preiszner Bálint , Papp Sándor , Vincze Ernő , Bókony Veronika , Liker András 
Published: April 2015

AbstractIn group‐living animals, individuals may benefit from the presence of an innovative group‐mate because new resources made available by innovators can be exploited, for example by scrounging or social learning. As a consequence, it may pay off to take the group‐mates' problem‐solving abilities into account in social interactions such as aggression or spatial association, for example because dominance over an innovative group‐mate can increase scrounging success, while spatial proximity may increase the chance of both direct exploitation and social learning. In this study, we tested whether the individuals' innovation success influences their social interactions with group‐mates in small captive flocks of house sparrows (Passer domesticus). First, we measured the birds' actual problem‐solving success in individual food‐extracting tasks. Then, we manipulated their apparent problem‐solving success in one task (by allowing or not allowing them to open a feeder repeatedly) while a new, unfamiliar group‐member (focal individual) had the opportunity to witness their performance. After this manipulation, we observed the frequency and intensity of aggression and the frequency of spatial associations between the focal individuals and their manipulated flock‐mates. Although flock‐mates behaved according to their treatments during manipulations, their apparent problem‐solving success did not affect significantly the focal individuals' agonistic behaviour or spatial associations. These results do not support that sparrows take flock‐mates' problem‐solving abilities into account during social interactions. However, focal individuals attacked those flock‐mates more frequently that had higher actual problem‐solving success (not witnessed directly by the focal individuals), although aggression intensity and spatial association by the focal birds were unrelated to the flock‐mates' actual success. If this association between flock‐mates' actual innovativeness and focal individuals' aggression is not due to confounding effects, it may imply that house sparrows can use more subtle cues to assess the group‐mates' problem‐solving ability than direct observation of their performance in simple foraging tasks.
Individual and Group Personalities Characterise Consensus Decision‐Making in an Ant
Authors: Cronin Adam L. 
Published: April 2015

AbstractNon‐human animals can exhibit idiosyncratic behaviour across individuals in much in the same way as humans. Animals with specific personalities may have advantages in some environments, and this idiosyncrasy may thus be of considerable ecological and evolutionary importance. In group‐living organisms, personality can occur at the level of the group as well as that of the individual. However, at present, we have very little understanding of the possible benefits of group‐level personality, and how this is linked with individual personality. In this study, I examine the influence of individual and group personality during the process of colony migration in the Japanese ant, Myrmecina nipponica. These ants use a consensus decision process to decide among alternatives when searching for a new home. Individuals contribute to this process by scouting for new nest sites, recruiting nestmates by laying pheromone trails, and carrying brood to the new site, although whether these roles are consistent among individuals and how roles are distributed within and between colonies remain unclear. Individual contributions to the nest‐site selection process were quantified over five repeated relocations in five colonies. Results demonstrate that contributions to the relocation effort were highly skewed within the colonies and that individuals were consistent in their contributions over repeated relocation events. Furthermore, the distribution of effort differed between colonies, indicating that intercolony differences in composition of behavioural types resulted in colony‐level personality. While these differences did not lead to any detectable difference in relocation performance between colonies in the simple experimental arrangement used, colony personality could influence decision outcomes in more complex environments.
Experimental test of the Invasional Meltdown Hypothesis: an exotic herbivore facilitates an exotic plant, but the plant does not reciprocally facilitate the herbivore
Authors: Meza‐Lopez Maria M. , Siemann Evan 
Published: April 2015

Summary

Ecosystems with multiple exotic species may be affected by facilitative invader interactions, which could lead to additional invasions (invasional meltdown hypothesis). Experiments show that one‐way facilitation favours exotic species and observational studies suggest that reciprocal facilitation among exotic species may lead to an invasional meltdown. We conducted a mesocosm experiment to determine whether reciprocal facilitation occurs in wetland communities.

We established communities with native wetland plants and aquatic snails. Communities were assigned to treatments: control (only natives), exotic snail (Pomacea maculata) invasion, exotic plant (Alternanthera philoxeroides) invasion, sequential invasion (snails then plants or plants then snails) or simultaneous invasion (snails and plants).

Pomacea maculata preferentially consumed native plants, so A. philoxeroides comprised a larger percentage of plant mass and native plant mass was lowest in sequential (snail then plant) invasion treatments.

Even though P. maculata may indirectly facilitate A. philoxeroides, A. philoxeroides did not reciprocally facilitate P. maculata. Rather, ecosystems invaded by multiple exotic species may be affected by one‐way facilitation or reflect exotic species’ common responses to abiotic factors or common paths of introduction.
From deep to shallow fluid reservoirs: evolution of fluid sources during exhumation of the Sierra Almagrera, Betic Cordillera, Spain
Authors: Dyja V. , Hibsch C. , Tarantola A. , Cathelineau M. , Boiron M.‐C. , Marignac C. , Bartier D. , Carrillo‐Rosúa J. , Ruano S. Morales , Boulvais P. 
Published: April 2015

AbstractThe combination of structural, geochemical and palaeotopographic data proves to be an efficient tool to understand fluid transfers in the crust. This study discriminates shallow and deep fluid reservoirs on both sides of the brittle–ductile transition under an extensional regime and points out the role of major transcurrent fault activity in this palaeohydrogeological setting. Palaeofluids trapped in quartz and siderite–barite veins record the transfer of fluids and metal solute species during the Neogene exhumation of the Sierra Almagrera metamorphic belt. Ductile then brittle–ductile extensional quartz veins formed from a deep fluid reservoir, trapping metamorphic secondary brines containing low‐density volatile phases derived from the dissolution of Triassic evaporites. During exhumation, low‐salinity fluids percolated within the brittle domain, as shown by transgranular fluid inclusion planes affecting previous veins. These observations indicate the opening of the system during Serravalian to early Tortonian times and provide evidence for the penetration of surficial fluids of meteoric or basinal origin into the upper part of the brittle–ductile transition. During exhumation, synsedimentary transcurrent tectonic processes occurred from late Tortonian times onwards, while marine conditions prevailed at the Earth's surface. At depth in the brittle domain, quartz veins associated with haematite record a return to high‐salinity fluid circulation suggesting an upward transfer fed from a lower reservoir. During the Messinian, ongoing activity of the trans‐Alboran tectono‐volcanic trend led to the formation of ore deposits. Reducing fluids caused the formation of siderite and pyrite ores. The subsequent formation of galena and barite may be related to an increase of temperature. The high salinity and Cl/Br ratio of the fluids suggest another source of secondary brine derived from dissolved Messinian evaporites, as corroborated by the δ34S signature of barite. These evaporites preceded the main sea‐level drop related to the peak of the salinity crisis (5.60–5.46 Ma).
SOLITARY TRICHOEPITHELIOMA WITH PROMINENT CYSTIC STRUCTURES
Authors: Ohkohchi Kyoko , Tagami Hachiro 
Published: April 2015

ABSTRACTWe describe a case of solitary protruding trichoepithelioma on the chin of a middle‐aged man that attained a large size in a relatively short period of time. Histologically, it showed a unique architecture consisting of tumor nests proliferating around a huge central keratinizing cyst and along sweat retention cysts.
PITYRIASIS ROSEA GIBERT AND MYCOPLASMA PNEUMONIAE INFECTION
Authors: Ishibashi Akira , Ueda Ikuyo , Fujita Keiichi 
Published: April 2015

ABSTRACTIn the patients with pityriasis rosea (Gibert), who came to our hospital in the period from November of 1979 to May of 1981, cold hemagglutinin (CHA), complement fixation (CF) and indirect hemagglutination (IHA) antibodies against Mycoplasma pneumoniae were observed. In 6 out of 30 cases, the CF titer was 1: 32 or higher and CHA 1: 128 or higher, indicating the presence of Mycoplasma pneumoniae infection; 22 cases were serologically positive and only 8 cases were negative for Mycoplasma pneumoniae.These results suggest that cases with pityriasis rosea may possibly be caused by Mycoplasma pneumoniae infection, although not all cases are serologically positive.
STRUCTURE AND EPITOPE SPECIFICITY OF HUMAN MELANOMA‐ASSOCIATED ONCOFETAL ANTIGEN gp87 ANALYZED WITH MONOCLONAL ANTIBODIES
Authors: Liao Shuen‐Kuei , Leung Wai‐Choi , Kanamaru Tetsuzan 
Published: April 2015

ABSTRACTMonoclonal antibodies provide one of the most powerful molecular‐recognition tools now available to the field of tumor immunology and other branches of biomedical research. Examples of applications of murine monoclonal antibodies to the epitope and structural analysis of a human melanoma‐associated oncofetal antigen gp87 are described.
PHOTOAGGRAVATION OF ACUTE FEBRILE NEUTROPHILIC DERMATOSIS (SWEET'S SYNDROME)
Authors: Horio Takeshi 
Published: April 2015

ABSTRACTPhototests were carried out in a patient with acute febrile neutrophilic dermatosis (Sweet's syndrome). The action spectrum of positive phototests was in the UVB range. Abnormal papular reaction was observed at uninvolved skin exposed to 5 MEDs with sun lamps. The cutaneous lesions were reproduced at the site of previous involvement and also in skin adjacent to existing lesion by 5 MED‐exposure. Another patient developed the disorder shortly after extensive sun exposure. These findings suggest that Sweet's syndrome may be provoked or aggravated by sunlight.
ABNORMALITIES OF FECAL FLORA IN PATIENTS WITH ACRODERMATITIS ENTEROPATHICA
Authors: Ishibashi Yasumasa , Nakabayashi Yasuharu , Kukita Atsushi , Benno Yoshimi , Mitsuoka Tomotari 
Published: April 2015

ABSTRACTFecal flora in two female patients with acrodermatitis enteropathica (AE) were investigated in connection with the efficacies of zinc sulfate and Entero‐Vioform (EV). The following results were obtained.

Drastic deviations from normal were found in the bacterial distributions in the feces of patients before treatment. In particular, Eubacterium, one of the commonest anaerobic bacteria in normal human feces, was not detected.
This characteristic finding was not altered by administration of zinc sulfate, although all clinical symptoms in the patients clearly improved.
The administration of EV, however, did return the numbers of this organism to almost normal levels, with clear improvement of clinical symptoms similar to that obtained with zinc sulfate.
These results suggest that intestinal flora may play an important role in the absorption of zinc from ordinary diets.
GLYCOSAMINOGLYCAN METABOLISM IN ATROPHIED SKIN FROM A PATIENT TREATED WITH LONG‐TERM ADMINISTRATION OF CORTICOSTEROIDS
Authors: Konohana Akira , Tajima Shingo , Nishikawa Takeji , Hatano Hitoshi 
Published: April 2015

ABSTRACTSkin tissue and explant culture were used to investigate glycosaminoglycan (GAG) metabolism in the atrophied skin of a patient treated with long‐term oral corticosteroids. Total GAGs per dry weight were almost the same in the atrophied and control skin. Hyaluronic acid was increased 1.5 times above the control values. Dermatan sulfate decreased to 3% of the total GAGs in the atrophied skin; in the controls dermatan sulfate content was 30%. In the skin explant culture experiment, the synthetic activity of dermatan sulfate in the atrophied skin was higher than in the controls. These results suggest that the synthesis of hyaluronic acid and dermatan sulfate in atrophied skin is modulated by corticosteroid, which causes thinning, fragile skin.
CYTODIAGNOSIS OF MALIGNANT MELANOMA BY THE TOUCH‐FLUORESCENCE METHOD
Authors: Morishima Takafumi , Kanematsu Shuichi , Fukada Eishun , Hanawa Shigeru , Nagashima Noriyasu 
Published: April 2015

ABSTRACTTwo cases of primary cutaneous melanoma with a granulomatous lesion were examined by the touch‐fluorescence method. This method makes it possible to demonstrate the melanogenic activity of melanoma cells within 30 minutes. The present study indicated that the touch‐fluorescence method using preparations from the outer surface of a lesion is helpful in preoperative diagnosis of malignant melanoma and that the same method using preparations from the cut surface is valuable in quick diagnosis of melanoma during surgery.