bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tetrahydrofuran (THF) in Urin – Addendum zur DFG‐Methode “Alkohole und Ketone” [Biomonitoring Methods in German language, 2012]
Authors: Blaszkewicz M. 
Published: October 2014

Abstract

Veröffentlicht in der Reihe
Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Analysen in biologischem Material
, 20. Lieferung, Ausgabe 2012

Der Artikel enthält folgende Kapitel:

Grundlage des Verfahrens

Geräte, Chemikalien und Lösungen

Geräte

Chemikalien

Vergleichsstandards

Probenahme und Probenaufbereitung

Instrumentelle Arbeitsbedingungen

Gaschromatographische Arbeitsbedingungen

Analytische Bestimmung

Kalibrierung

Berechnung der Analysenergebnisse

Standardisierung der Messergebnisse und Qualitätssicherung

Beurteilung des Verfahrens

Präzision

Richtigkeit

Nachweis‐ und Bestimmungsgrenze

Störeinflüsse

Diskussion der Methode
Tetrahydrofuran (THF) in urine (Addendum to the DFG method “Alcohols and Ketones”) [Biomonitoring Methods, 2013]
Authors: Blaszkewicz M. 
Published: October 2014

Abstract

Published in the series
Biomonitoring Methods
, Vol. 13 (2013)

The article contains sections titled:

General principles

Equipment, chemicals and solutions

Equipment

Chemicals

Calibration standards

Specimen collection and sample preparation

Operational parameters

Operational parameters for gas chromatography

Analytical determination

Calibration

Calculation of the analytical result

Standardisation and quality control

Evaluation of the method

Precision

Accuracy

Detection limits and quantitation limits

Sources of error

Discussion of the method

Appendix
N‐(2,3‐Dihydroxypropyl)‐Valin als Hämoglobinaddukt des Glycidols [Biomonitoring Methods in German language, 2012]
Authors: Müller M. 
Published: October 2014

AbstractVeröffentlicht in der ReiheAnalytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Analysen in biologischem Material, 20. Lieferung, Ausgabe 2012Der Artikel enthält folgende Kapitel:Grundlage des VerfahrensGeräte, Chemikalien und LösungenGeräteChemikalienLösungenVergleichsstandardsProbenahme und ProbenaufbereitungGewinnung des ErythrozytenlysatsIsolierung des GlobinsDerivatisierung des GlobinsInstrumentelle ArbeitsbedingungenGaschromatographische ArbeitsbedingungenMassenspektrometrische ArbeitsbedingungenAnalytische BestimmungKalibrierungBerechnung der AnalysenergebnisseStandardisierung der Messergebnisse und QualitätssicherungBeurteilung des VerfahrensPräzisionRichtigkeitNachweis‐ und BestimmungsgrenzeStöreinflüsseDiskussion der Methode
N‐(2,3‐Dihydroxypropyl)‐valine in blood as haemoglobin adduct of glycidol [Biomonitoring Methods, 2013]
Authors: Müller M. 
Published: October 2014

Abstract

Published in the series
Biomonitoring Methods
, Vol. 13 (2013)

The article contains sections titled:

General principles

Equipment, chemicals and solutions

Equipment

Chemicals

Solutions

Internal standard

Calibration standards

Specimen collection and sample preparation

Preparation of the erythrocyte lysate

Isolation of the globin

Derivatisation of the globin

Operational parameters

Operational parameters for gas chromatography

Operational parameters for mass spectrometry

Analytical determination

Calibration

Calculation of the analytical result

Standardisation and quality control

Evaluation of the method

Precision

Accuracy

Detection limit and quantitation limit

Sources of error

Discussion of the method

Appendix
Selen in Serum [Biomonitoring Methods in German language, 2012]
Authors: Heitland P. 
Published: October 2014

AbstractVeröffentlicht in der ReiheAnalytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Analysen in biologischem Material, 20. Lieferung, Ausgabe 2012Der Artikel enthält folgende Kapitel:Grundlage des VerfahrensGeräte, Chemikalien und LösungenGeräteChemikalienLösungenVergleichsstandardsProbenahme und ProbenaufbereitungInstrumentelle ArbeitsbedingungenAnalytische BestimmungKalibrierungBerechnung der AnalysenergebnisseStandardisierung der Messergebnisse und QualitätssicherungBeurteilung des VerfahrensPräzisionRichtigkeitNachweis‐ und BestimmungsgrenzeStöreinflüsseDiskussion der Methode
Pyrethrum‐ und Pyrethroidmetabolite (nach Flüssig‐Flüssigextraktion) in Urin [Biomonitoring Methods in German language, 2012]
Authors: Leng G. , Gries W. 
Published: October 2014

AbstractVeröffentlicht in der ReiheAnalytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Analysen in biologischem Material, 20. Lieferung, Ausgabe 2012Der Artikel enthält folgende Kapitel:Grundlage des VerfahrensGeräte, Chemikalien und LösungenGeräteChemikalienLösungenVergleichsstandardsProbenahme und ProbenaufbereitungProbenahmeProbenaufbereitungInstrumentelle ArbeitsbedingungenGaschromatographische ArbeitsbedingungenAlternative Gaschromatographische ArbeitsbedingungenMassenspektrometrische ArbeitsbedingungenAlternative massenspektrometrische ArbeitsbedingungenAnalytische BestimmungKalibrierungBerechnung des AnalysenergebnissesStandardisierung der Messergebnisse und QualitätssicherungBeurteilung des VerfahrensPräzisionRichtigkeitAbsolute WiederfindungNachweis‐ und BestimmungsgrenzeStöreinflüsseDiskussion der Methode
Novel Method to Collect Medication Adverse Events in Juvenile Arthritis: Results From the Childhood Arthritis and Rheumatology Research Alliance Enhanced Drug Safety Surveillance Project
Authors: Ringold Sarah , Hendrickson Audrey , Abramson Leslie , Beukelman Timothy , Blier Peter R. , Bohnsack John , Chalom Elizabeth C. , Gewanter Harry L. , Gottlieb Beth , Hollister Roger , Hsu Joyce , Hudgins Andrea , Ilowite Norman T. , Klein‐Gitelman Marisa , Lindsley Carol , Lopez Benitez Jorge M. , Lovell Daniel J. , Mason Tom , Milojevic Diana , Moorthy Lakshmi N. , Nanda Kabita , Onel Karen , Prahalad Sampath , Rabinovich C. Egla , Ray Linda , Rouster‐Stevens Kelly , Ruth Natasha , Shishov Michael , Spalding Steven , Syed Reema , Stoll Matthew , Vehe Richard K. , Weiss Jennifer E. , White Andrew J. , Wallace Carol A. , Sobel Rachel E. 
Published: October 2014

ObjectiveFew data are available regarding the rates of serious adverse events (SAEs) and important medical events (IMEs) outside of product‐based registries and clinical trials for juvenile idiopathic arthritis (JIA). The Enhanced Drug Safety Surveillance Project (EDSSP) was developed to pilot a novel system to collect SAEs/IMEs in children with JIA. This analysis reports the results from this 4‐year (2008–2012) EDSSP.MethodsParticipating physicians were surveyed monthly to ascertain whether their JIA patients experienced an SAE or IME. Sites were surveyed every 6 months to determine the number of unique JIA patients seen at each site during that 6‐month period. Reporting rates were calculated per 100 person‐years and 95% confidence intervals (95% CIs) were calculated based on a Poisson distribution.ResultsThirty‐seven Childhood Arthritis and Rheumatology Research Alliance sites with 115 physicians participated. The mean response rate to the monthly surveys was 65%. There were 147 total SAEs and 145 total IMEs. The largest proportion of SAEs and IMEs occurred in children with polyarticular JIA (39% and 37%, respectively). The majority of SAEs and IMEs were reported for patients receiving therapy with biologic agents (76% and 69%, respectively). The total event rate for SAEs and IMEs combined was 1.07 events per 100 person‐years (95% CI 0.95–1.19). The rates for SAEs and IMEs were 0.54 per 100 person‐years (95% CI 0.45–0.63) and 0.53 per 100 person‐years (95% CI 0.49–0.62), respectively.ConclusionThe EDSSP provided a simple tool for SAE/IME reporting within an established research network and resulted in a similar range of reported events as captured by a traditional product‐based registry.
Lower‐Extremity Osteoarthritis and the Risk of Falls in a Community‐Based Longitudinal Study of Adults With and Without Osteoarthritis
Authors: Doré Adam L. , Golightly Yvonne M. , Mercer Vicki S. , Shi Xiaoyan A. , Renner Jordan B. , Jordan Joanne M. , Nelson Amanda E. 
Published: October 2014

ObjectiveKnee and hip osteoarthritis (OA) are known risk factors for falls, but whether they together additionally contribute to falls risk is unknown. This study utilizes a biracial cohort of men and women to examine the influence of lower‐extremity OA burden on the risk for future falls.MethodsA longitudinal analysis was performed using data from 2 time points of a large cohort. The outcome of interest was falls at followup. Covariates included age, sex, race, body mass index, a history of prior falls, symptomatic OA of the hip and/or knee, a history of neurologic or pulmonary diseases, and current use of narcotic medications. Symptomatic OA was defined as patient‐reported symptoms and radiographic evidence of OA in the same joint. Logistic regression analyses were used to determine associations between covariates and falls at followup.ResultsThe odds of falling increased with an increasing number of lower‐extremity symptomatic OA joints: those with 1 joint had 53% higher odds, those with 2 joints had 74% higher odds, and those with 3–4 OA joints had 85% higher odds. When controlling for covariates, patients who had symptomatic knee or hip OA had an increased likelihood of falling (adjusted odds ratio [aOR] 1.39, 95% confidence interval [95% CI] 1.02–1.88 and aOR 1.60, 95% CI 1.14–2.24, respectively).ConclusionThis study reveals the risk for falls increases with additional symptomatic OA lower‐extremity joints and confirms that symptomatic hip and knee OA are important risk factors for falls.
Work‐related violence experienced by urban taxi drivers
Authors: Burgel Barbara J. , Gillen Marion , White Mary C. 
Published: October 2014

ObjectivesThis study measured violence (physical assault, robbery, or weapon confrontation) in taxi drivers, and determined socio‐demographic/work factors associated with violence.MethodsIn 2010, 130 taxi drivers, working in a large city in the Western US, were administered a survey evaluating workplace violence events.ResultsThe study population was male (94%), mean age 45, married (54%), foreign‐born (55%), with 24% speaking Arabic at home. Drivers drove at night (51%), for an average of 9.7 years and 41 hr/week. Almost half reported a history of violence during their driving careers: physical assault, weapon confrontation, or robbery. In the prior 12 months, 12% were physically assaulted, 8% robbed, and 6% confronted with a weapon. Night drivers reported more assaults over their lifetime compared to day drivers (mean = 1.64 [sd 4.29] vs. mean = 0.53 [sd 1.05], P = 0.047).ConclusionsTaxi drivers experience violence at work. Strategies are needed to prevent violence especially in night drivers. Am. J. Ind. Med. 57:1377–1385, 2014. © 2014 Wiley Periodicals, Inc.
Hominin teeth from the early Late Pleistocene site of Xujiayao, Northern China
Authors: Xing Song , Martinón‐Torres María , Bermúdez de Castro Jose María , Wu Xiujie , Liu Wu 
Published: October 2014

ABSTRACTIt is generally accepted that from the late Middle to the early Late Pleistocene (∼340–90 ka BP), Neanderthals were occupying Europe and Western Asia, whereas anatomically modern humans were present in the African continent. In contrast, the paucity of hominin fossil evidence from East Asia from this period impedes a complete evolutionary picture of the genus Homo, as well as assessment of the possible contribution of or interaction with Asian hominins in the evolution of Homo sapiens and Homo neanderthalensis. Here we present a comparative study of a hominin dental sample recovered from the Xujiayao site, in Northern China, attributed to the early Late Pleistocene (MIS 5 to 4). Our dental study reveals a mosaic of primitive and derived dental features for the Xujiayao hominins that can be summarized as follows: i) they are different from archaic and recent modern humans, ii) they present some features that are common but not exclusive to the Neanderthal lineage, and iii) they retain some primitive conformations classically found in East Asian Early and Middle Pleistocene hominins despite their young geological age. Thus, our study evinces the existence in China of a population of unclear taxonomic status with regard to other contemporary populations such as H. sapiens and H. neanderthalensis. The morphological and metric studies of the Xujiayao teeth expand the variability known for early Late Pleistocene hominin fossils and suggest the possibility that a primitive hominin lineage may have survived late into the Late Pleistocene in China. Am J Phys Anthropol 156:224–240, 2015. © 2014 Wiley Periodicals, Inc.
The contribution of erectile elements to nasal patency: an examination with nasal sound analysis
Authors: Tahamiler Rauf , Alimoglu Yalçin , Canakcioglu Salih 
Published: October 2014

BackgroundThe objective of this work was to determine the role of nasal sound analysis using a software called Odiosoft‐Rhino (OR) in evaluation of nasal erectile elements as a cause of nasal obstruction. Comparisons of nasal resistance, amplitude of the nasal sound frequency spectra, and visual analogue score (VAS) were made.MethodsNasal endoscopy, VAS, rhinomanometry (RMM), and OR were performed on 64 patients with inferior turbinate hypertrophy but without any other nasal problems, both untreated and 15 minutes after the application of topical decongestants (TDs). Results were compared and any correlation was investigated.ResultsFor inspiration, the OR intervals for both sides at all 5 frequency intervals changes significantly with decongestion, except for the left side at 0.5 to 1 kHz. For expiration, the OR intervals for both sides changed significantly for 0.2 to 0.5 KHz and 2 to 4 kHz, but not for the other 3 frequency intervals. VAS correlated well with physical examination, both inspiratory and expiratory RMM, and 2 to 4 kHz inspiratory and expiratory nasal sound on both sides both before and after TD application. The 2 to 4 kHz inspiratory and expiratory nasal sound on both sides correlated well with inspiratory and expiratory RMM on both sides both before and after TD application.ConclusionOR is an efficient and reliable method to evaluate the role of the erectile components in nasal patency in the absence of allergy or septal deviation. It is practical and may be used in routine clinical practice.
Severe hypothermia secondary to spinal cord injury without radiographic abnormality
Authors: Kanezaki Shozo , Ishii Keisuke , Miyazaki Masashi , Tanabe Sanshi , Kurosawa Keiko , Tsumura Hiroshi 
Published: October 2014

CaseA 64‐year‐old female was found lying by a river. She was unconscious and her lower body was under water. The patient was transported to the emergency room of our hospital. On arrival, her rectal temperature was 24.6°C. We immediately started rewarming and artificial respiration. Five days after admission, rewarming was completed and she became conscious and could communicate. Initially, she had been injured and examination showed paraplegia. Magnetic resonance imaging of her cervical spine showed no findings indicating bony or ligament injury, but there was a T2 high intensity area at C5/6 and C6/7 levels. The patient was diagnosed with spinal cord injury without radiological abnormality.OutcomeAt 5 months post‐injury, the patient was able to walk without crutches.ConclusionSpinal cord injury might be missed if there are no radiographic abnormalities. Spinal cord injury without radiological abnormality should be considered as a differential diagnosis of accidental hypothermia.
Delayed visceral ischemia induced by type B aortic dissection
Authors: Kurumisawa Soki , Sugaya Akira , Akutsu Hirohiko , Takazawa Ippei , Ohki Shin‐ichi , Misawa Yoshio 
Published: October 2014

CaseA 56‐year‐old man presented with a sudden severe abdominal pain 13 days after the onset of type B acute aortic dissection. Chest computed tomography revealed type B aortic dissection, and the true lumen was narrowed by the expanding false lumen. Blood flow through the celiac trunk, superior mesenteric artery, and left renal artery was reduced. Blood flow through the distal abdominal aorta and bilateral femoral arteries was clearly recognized. Laboratory findings such as transaminases were rapidly worsening.OutcomeThe patient underwent emergency fenestration of the abdominal aorta and recovered without organ failure.ConclusionsRapidly worsening laboratory findings led us to emergency operation with successful results. Serial monitoring of laboratory findings is the key for adequate timing of operation.
Synthesis of Di‐, Tri‐, and Tetrasubstituted Oxetanes by Rhodium‐Catalyzed OH Insertion and CC Bond‐Forming Cyclization
Authors: Davis Owen A. , Bull James A. 
Published: October 2014

AbstractOxetanes offer exciting potential as structural motifs and intermediates in drug discovery and materials science. Here an efficient strategy for the synthesis of oxetane rings incorporating pendant functional groups is described. A wide variety of oxetane 2,2‐dicarboxylates were accessed in high yields, including functionalized 3‐/4‐aryl‐ and alkyl‐substituted oxetanes and fused oxetane bicycles. Enantioenriched alcohols provided enantioenriched oxetanes with complete retention of configuration. The oxetane products were further derivatized, while the ring was maintained intact, thus highlighting their potential as building blocks for medicinal chemistry.
Synthesis and characterization of tributyltin derivatives from 4‐oxo‐4‐(arylamino)butanoic acids and their in vitrobiological activity against cervical cancer cell lines
Authors: Rojas‐Oviedo Irma , Camacho‐Camacho Carlos , Sánchez‐Sánchez Luis , Cárdenas Jorge , López‐Muñoz Hugo , Eugenio‐Robledo Hugo , Velázquez Israel , Toscano Rubén Alfredo 
Published: October 2014

Uterine (cervix and corpus) cancer is one of the major causes of mortality in women in Mexico. Organotin carboxylated derivatives have shown high cytotoxic activity against various cell lines of human origin. We describe the synthesis of three new tri‐n‐butyltin derivatives from 4‐oxo‐4‐(arylamino)butanoic acids; their structures were confirmed using spectral data (1H NMR, 13C NMR, 119Sn NMR and infrared), elemental analyses, mass spectrometry and X‐ray diffraction. All the tri‐n‐butyltin carboxylates exhibit 1 J (119/117Sn–13C) coupling satellites in solution and lie in the range 357 to 339 Hz, suggesting a tetrahedral geometry around the tin atom. The polymeric structures of two of the derivatives and the monomeric structure of another were confirmed using X‐ray crystallography. Using succinic anhydride as raw material, five N‐substituted succinamic acid compounds were synthesized by the acylation reaction with aniline, 4‐nitroaniline, 4‐nitro‐3‐(trifluoromethyl)aniline, 2‐amino‐5‐nitrothiazole and 4‐aminoantipyrine. From these compounds, five tin derivatives were prepared and their in vitro anti‐proliferative effect on HeLa, CaSki and ViBo cell lines was screened. All of the compounds showed potency against all three strains and null or low cytotoxic activity (necrotic) as well. The most potent of our derivatives as an anti‐proliferative agent against the three cell lines was tributylstannyl 4‐oxo‐4‐[(3‐trifluoromethyl‐4‐nitrophen‐1‐yl)amino]butanoate, exhibiting an IC50 value of 0.43 μM against the HeLa cell line. Copyright © 2014 John Wiley & Sons, Ltd.
Peripheral CD5+ B Cells in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Authors: Unizony Sebastian , Lim Noha , Phippard Deborah J. , Carey Vincent J. , Miloslavsky Eli M. , Tchao Nadia K. , Iklé David , Asare Adam L. , Merkel Peter A. , Monach Paul A. , Seo Philip , St.Clair E. William , Langford Carol A. , Spiera Robert , Hoffman Gary S. , Kallenberg Cees G. M. , Specks Ulrich , Stone John H. 
Published: October 2014

ObjectiveCD5+ B cells have been conceptualized as a possible surrogate for Breg cells. The aim of the present study was to determine the utility of CD5+ B cells as biomarkers in antineutrophil cytoplasmic antibody–associated vasculitis (AAV).MethodsThe absolute and relative numbers (percentages) of CD5+ B cells (explanatory variables) were measured longitudinally during 18 months in 197 patients randomized to receive either rituximab (RTX) or cyclophosphamide (CYC) followed by azathioprine (AZA) for the treatment of AAV (Rituximab in ANCA‐Associated Vasculitis [RAVE] trial). Outcome variables included disease activity (status of active disease versus complete remission), responsiveness to induction therapy, disease relapse, disease severity, and, in RTX‐treated patients, relapse‐free survival according to the percentage of CD5+ B cells detected upon B cell repopulation.ResultsCD5+ B cell numbers were comparable between the treatment groups at baseline. After an initial decline, absolute CD5+ B cell numbers progressively increased in patients in the RTX treatment arm, but remained low in CYC/AZA‐treated patients. In both groups, the percentage of CD5+ B cells increased during remission induction and slowly declined thereafter. During relapse, the percentage of CD5+ B cells correlated inversely with disease activity in RTX‐treated patients, but not in patients who received CYC/AZA. No significant association was observed between the numbers of CD5+ B cells and induction treatment failure or disease severity. The dynamics of the CD5+ B cell compartment did not anticipate disease relapse. Following B cell repopulation, the percentage of CD5+ B cells was not predictive of time to flare in RTX‐treated patients.ConclusionThe percentage of peripheral CD5+ B cells might reflect disease activity in RTX‐treated patients. However, sole staining for CD5 as a putative surrogate marker for Breg cells did not identify a subpopulation of B cells with clear potential for meaningful clinical use. Adequate phenotyping of Breg cells is required to further explore the value of these cells as biomarkers in AAV.
An Evaluation of Risk Factors for Major Adverse Cardiovascular Events During Tocilizumab Therapy
Authors: Rao Vijay U. , Pavlov Andrey , Klearman Micki , Musselman David , Giles Jon T. , Bathon Joan M. , Sattar Naveed , Lee Janet S. 
Published: October 2014

ObjectiveTo evaluate associations between lipid levels, inflammation, and rheumatoid arthritis (RA) disease activity, at baseline and during treatment, with the risk of major adverse cardiovascular events (MACE) in tocilizumab‐treated patients with RA.MethodsIn retrospective post hoc analyses, data were pooled for 3,986 adult patients with moderate to severe RA who received ≥1 dose of tocilizumab (4 mg/kg or 8 mg/kg) intravenously every 4 weeks in randomized controlled trials and extension studies. Cox proportional hazards modeling was used to evaluate associations between baseline characteristics and posttreatment changes in laboratory and disease characteristics (week 24) and change in disease activity and laboratory values from baseline to week 24 with the risk of future MACE during extended followup.ResultsWe identified 50 independently adjudicated cases of MACE during 14,683 patient‐years of followup (0.34 MACE cases/100 patient‐years). At baseline, age, a history of cardiac disorders, the Disease Activity Score in 28 joints (DAS28), and the total cholesterol:high‐density lipoprotein cholesterol ratio were independently associated with MACE in multivariable models (P < 0.05 for all). During treatment, a higher DAS28 and higher swollen and tender joint counts at week 24 were associated with future MACE. In separate models, greater reductions in the DAS28 and joint counts from baseline to week 24 were inversely associated with future MACE; changes in lipid parameters were not statistically significantly associated with the risk of MACE.ConclusionIn this population of patients treated with tocilizumab, an association was observed between the baseline total cholesterol:high‐density lipoprotein cholesterol ratio and an increased risk of MACE. The risk of MACE while receiving treatment, however, was associated with control of disease activity but not lipid changes. Larger studies are needed to confirm these findings.