bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Determination and Monitoring of Biomarkers of Necrosis and Myocardial Remodeling between Radiofrequency Ablation and Cryoablation
Authors: HERNÁNDEZ‐ROMERO DIANA , MARÍN FRANCISCO , ROLDÁN VANESSA , PEÑAFIEL PABLO , VILCHEZ JUAN ANTONIO , ORENES‐PIÑERO ESTEBAN , GINER JOSÉ ANTONIO , VALDÉS MARIANO , GARCÍA‐ALBEROLA ARCADIO 
Published: October 2012

BackgroundBiomarkers of necrosis and inflammation have been found raised after radiofrequency ablation (RF). There is scarce information on biomarkers’ behavior after cryoablation. Our aim was to study biomarkers of necrosis, inflammation, and interstitial remodeling after two different approaches: RF versus cryoablation.MethodsWe studied 22 consecutive patients with atrial flutter who underwent RF (10) or cryoablation (12). All patients underwent electrophysiological study and subsequent ablation. Peripheral samples were collected before the procedure, immediately after, the following day, 3 days, 1 week, 1 month, and 2 months after ablation. Samples were assayed for biomarkers of inflammation (high sensitive C‐reactive protein [hs‐CRP]) and tissue remodeling (C‐propeptide of type I procollagen [CICP], matrix metalloproteinase 2 [MMP‐2], matrix metalloproteinase 9 [MMP‐9], and metallopeptidase inhibitor 1 [TIMP‐1]). We also determined biomarkers of tissue necrosis (creatine kinase [CK], its MB isoenzyme, cardiac troponin I [TnI], and troponin T (TnT)] in samples obtained immediately after ablation, 6 hours postablation, and 12 hours postablation.ResultsBidirectional isthmus block was achieved in all patients. We found significantly higher levels of CK, CK‐MB, and TnI after cryoablation compared to RF ablation for all timing samples. These necrosis biomarkers showed significant differences depending on the time (all P < 0.001), and the interaction between the time and the used ablation approach (P = 0.005, P < 0.001, and P < 0.001, respectively). For patients who undergoing RF ablation, MMP‐2 showed the greatest changes depending on the interaction between time and number of applications (P = 0.041), whereas for patients who undergoing cryoablation, CK was the most relevant biomarker depending on the interaction between time and number of applications (P = 0.006).ConclusionsWe show higher levels of necrosis and myocardial injury biomarker after cryoablation versus RF. However, we found higher remodeling processes after RF. Our data support previous publications showing different lesion formation in cryoablation and RF.(PACE 2013; 36:31–36)
Proteomic changes associated with freeze‐thaw injury and post‐thaw recovery in onion (Allium cepa L.) scales
Authors: CHEN KETING , RENAUT JENNY , SERGEANT KJELL , WEI HUI , ARORA RAJEEV 
Published: October 2012

ABSTRACTThe ability of plants to recover from freeze‐thaw injury is a critical component of freeze‐thaw stress tolerance. To investigate the molecular basis of freeze‐thaw recovery, here we compared the proteomes of onion scales from unfrozen control (UFC), freeze‐thaw injured (INJ), and post‐thaw recovered (REC) treatments. Injury‐related proteins (IRPs) and recovery‐related proteins (RRPs) were differentiated according to their accumulation patterns. Many IRPs decreased right after thaw without any significant re‐accumulation during post‐thaw recovery, while others were exclusively induced in INJ tissues. Most IRPs are antioxidants, stress proteins, molecular chaperones, those induced by physical injury or proteins involved in energy metabolism. Taken together, these observations suggest that while freeze‐thaw compromises the constitutive stress protection and energy supply in onion scales, it might also recruit ‘first‐responders’ (IRPs that were induced) to mitigate such injury. RRPs, on the other hand, are involved in the injury‐repair program during post‐thaw environment conducive for recovery. Some RRPs were restored in REC tissues after their first reduction right after thaw, while others exhibit higher abundance than their ‘constitutive’ levels. RRPs might facilitate new cellular homeostasis, potentially by re‐establishing ion homeostasis and proteostasis, cell‐wall remodelling, reactive oxygen species (ROS) scavenging, defence against possible post‐thaw infection, and regulating the energy budget to sustain these processes.
ArabidopsisROP‐interactive CRIB motif‐containing protein 1 (RIC1) positively regulates auxin signalling and negatively regulates abscisic acid (ABA) signalling during root development
Authors: CHOI YUNJUNG , LEE YUREE , KIM SOO YOUNG , LEE YOUNGSOOK , HWANG JAE‐UNG 
Published: October 2012

ABSTRACTAuxin and abscisic acid (ABA) modulate numerous aspects of plant development together, mostly in opposite directions, suggesting that extensive crosstalk occurs between the signalling pathways of the two hormones. However, little is known about the nature of this crosstalk. We demonstrate that ROP‐interactive CRIB motif‐containing protein 1 (RIC1) is involved in the interaction between auxin‐ and ABA‐regulated root growth and lateral root formation. RIC1 expression is highly induced by both hormones, and expressed in the roots of young seedlings. Whereas auxin‐responsive gene induction and the effect of auxin on root growth and lateral root formation were suppressed in theric1knockout, ABA‐responsive gene induction and the effect of ABA on seed germination, root growth and lateral root formation were potentiated. Thus, RIC1 positively regulates auxin responses, but negatively regulates ABA responses. Together, our results suggest that RIC1 is a component of the intricate signalling network that underlies auxin and ABA crosstalk.
Preferential Trade and Welfare with Differentiated Products
Authors: Konan Denise Eby , Maskus Keith E. 
Published: October 2012

AbstractWe consider analytically and numerically the welfare tradeoffs inherent in a preferential trade area (PTA) with products differentiated by region of origin. For a small open economy in such a setting, welfare gains are associated with higher trade volumes within the PTA. However, welfare losses are induced by declining tariff revenues on trade with non‐member countries. We show that both effects are concave, while one is a non‐monotonic and the other a potentially non‐monotonic function of pre‐PTA partner trade shares. Therefore, the relationship between initial partner import shares and direct static welfare impacts of a PTA are theoretically ambiguous. This finding contrasts with conventional results in the homogeneous‐goods case, whereby the smaller is the pre‐agreement trade volume with a potential partner the more beneficial is a PTA.
Trade Costs, Resource Reallocation and Productivity in Developing Countries
Authors: Blyde Juan , Iberti Gonzalo 
Published: October 2012

AbstractNew trade models with heterogeneous firms suggest that international trade plays an important role in reallocating resources from low to high productivity plants. We use plant‐level data from Chile and measures of trade costs that include tariffs and freight rates to analyze the importance of this trade‐induced market selection process. We find that trade costs affect the reallocation process through the various channels predicted by the theory; however, the effects are approximately half of those reported for the US. We also find that while the tariff rate is responsible for preventing some of the reallocation, transportation costs have the most limiting role in terms of the number of channels affected.
Does High‐skilled Migration Affect Publicly Financed Investments?
Authors: Grossmann Volker , Stadelmann David 
Published: October 2012

AbstractThis paper analyzes the interaction between migration of high‐skilled labor and publicly financed investment. We develop a theoretical model with multiple, ex ante identical jurisdictions where individuals decide on education and subsequent emigration. Migration decisions are based on differences in net income across jurisdictions which may occur endogenously. The interaction between income differences and migration flows gives rise to the potential of multiple equilibria: a symmetric equilibrium without migration and an asymmetric equilibrium in which net income levels differ among jurisdictions and trigger migration flows. In the former equilibrium, all jurisdictions have the same public investment level. In the latter one, public investment is high in host economies of skilled expatriates and low in source economies. We empirically test the hypothesis that emigration rates are negatively associated with publicly financed investment levels for OECD countries.
Selection, Market Size and International Integration: Do Vertical Linkages Play a Role?
Authors: Nocco Antonella 
Published: October 2012

AbstractWe analyze how increases in the market size and in the level of international integration affect the process of selection among firms with heterogeneous productivity levels when they are interconnected by vertical linkages. We show that when vertical linkages among firms are relatively weak (strong), an increase in the market size softens (toughens) the competition facing firms in this market and more firms of a lower (higher) efficiency survive, increasing (decreasing) the welfare level. Moreover, an increase in the level of economic integration softens competition only for intermediate vertical linkages, worsening the welfare level only for strong linkages.
Does Occupational Training by the Trade Adjustment Assistance Program Really Help Reemployment? Success Measured as Occupation Matching
Authors: Park Jooyoun 
Published: October 2012

AbstractThe Trade Adjustment Assistance Program provides various retraining opportunities to workers displaced due to import competition. This paper investigates whether successful skill acquisition through training—as opposed to general exposure to federal assistance—improves the post‐participation outcomes using the Trade Act Participant Report. Success in skill acquisition is indicated by a match between occupations of training and entered employment. The average matching rate for the sample is 37.53%. Trainees with a match display wage replacement rates that are 2 to 3 percentage points higher than those without one, while they display very similar post‐participation earnings that are inferior to that of non‐trainees. This generally indicates that participants with limited skill sets with lower pre‐participation earnings select into training, and successful skill acquisition offsets the negative impacts of their lack of marketable skills. Matching itself does not improve the retention at the job. However, participation in various training programs improves retention.
Foreign Banks and Credit Volatility: The Case of Latin American Countries
Authors: Haouat Meriem , Moccero Diego N. , Sosa Navarro Ramiro 
Published: October 2012

AbstractThe number of foreign banks in Latin America increased substantially over the period 1995–2001, prompting a debate on the potential consequences for host countries. Discussions focused on efficiency, the impact on competition and product market diversification in the banking industry, and the quality of the regulatory environment, among other issues. Against this background, this paper uses ARCH techniques to test the impact of foreign banks on both the level and the volatility of real private bank credit in a panel of eight Latin American countries, using quarterly data over the period 1995–2001. The empirical findings show that, together with financial development, the presence of foreign banks has contributed to reducing real credit volatility, improving the buffer shock function of the banking sector.
An Extended Ricardian Model Incorporating a Consumption Time Constraint
Authors: Tran‐Nam Binh 
Published: October 2012

AbstractThis paper investigates the impact of incorporating a Gossenian−Beckerian consumption time constraint into a simple Ricardian model. It is shown that in such a model the consumption gain from trade is zero, the specialization gain can be negative and a small nation devotes less labor to production after trade.
Risk factors for development of sterile haemorrhagic cystitis in canine lymphoma patients receiving oral cyclophosphamide: a case–control study
Authors: Gaeta R. , Brown D. , Cohen R. , Sorenmo K. 
Published: October 2012

AbstractSterile haemorrhagic cystitis (SHC) is a known risk of cyclophosphamide treatment; however, most canine reports are case series. This case–control study examined risk factors forSHCin dogs with lymphoma receiving oral cyclophosphamide. Twenty‐two dogs withSHCand 66 control dogs were identified. On univariate analysis,SHCrisk factors included age (P = 0.041), induction protocol (P = 0.021) and cumulative cyclophosphamide dose (P = 0.002). On multivariate analysis, increasing cumulative cyclophosphamide dose was associated with increased risk ofSHCand the ‘short’ induction protocol (protocol 1) was associated with decreased risk. Controlling for age and induction protocol, odds ofSHCincreased by 2.21 per 750 mg m−2increase in cyclophosphamide dose (P = 0.001).SHCfrom oral cyclophosphamide is a predominately delayed toxicity resulting from high cumulative doses.
Bioluminescent Enzyme Immunoassay for the Detection of Norovirus Capsid Antigen
Authors: Sakamaki Nozomi , Ohiro Yoshiyuki , Ito Mitsuki , Makinodan Mitsuru , Ohta Tsubasa , Suzuki Wataru , Takayasu Susumu , Tsuge Harufumi 
Published: October 2012

ABSTRACTAn ultrasensitive and fully automated bioluminescent enzyme immunoassay (BLEIA) was developed for the detection of norovirus (NV) capsid antigen. In the evaluation tests with recombinant virus-like particles, the BLEIA demonstrated broad reactivity against several NV genotypes (genotypes 1, 3, 4, 7, 8, and 12 in genogroup I [GI] and genotypes 1, 2, 3, 4, 5, 6, 12, and 13 in GII), a wide dose-response range from 0.25 pg/ml to 10,000 pg/ml, and good reproducibility with low coefficients of variation (CVs) (within-run CVs of <2.8%, between-day CVs of <3.7%). In the evaluation tests with NV-positive fecal samples, a good correlation (y= 0.66x −3.21,r= 0.84) between the BLEIA and real-time quantitative reverse transcription-PCR was obtained. Furthermore, in the dilution test with NV specimens, the analytical sensitivity of NV was estimated to be 105to 106copies/g of fecal sample, indicating that the analytical sensitivity of the BLEIA is comparable to that of commercially available molecular methods. All assay steps are fully automated, the turnaround time is 46 min, and the throughput of the assay is 120 tests/h. These results indicate that the BLEIA is potentially useful for the rapid diagnosis of NV in epidemic and sporadic gastroenteritis.
Comparison of Four Assays for the Detection of Cryptococcal Antigen
Authors: Binnicker M. J. , Jespersen D. J. , Bestrom J. E. , Rollins L. O. 
Published: October 2012

ABSTRACT

We compared the performance of four assays for the detection of cryptococcal antigen in serum samples (
n
= 634) and cerebrospinal fluid (CSF) samples (
n
= 51). Compared to latex agglutination, the sensitivity and specificity of the Premier enzyme immunoassay (EIA), Alpha CrAg EIA, and CrAg lateral flow assay (LFA) were 55.6 and 100%, 100 and 99.7%, and 100 and 99.8%, respectively, from serum samples. There was 100% agreement among the four tests for CSF samples, with 18 samples testing positive by each of the assays.
Complete Genome Sequences of Novel Rat Noroviruses in Hong Kong
Authors: Tse Herman , Chan Wan-Mui , Lam Carol S. F. , Lau Susanna K. P. , Woo Patrick C. Y. , Yuen Kwok-Yung 
Published: October 2012

ABSTRACT
We report two genome sequences of novel noroviruses isolated from fecal swab specimens of brown rats in Hong Kong. The complete genome is approximately 7.5 kb in length and consists of 3 overlapping open reading frames encoding ORF1 polyprotein, VP1, and VP2, respectively. Sequence analysis suggested that these noroviruses should be classified in genogroup V, but they are distinct from other known rodent noroviruses and represent a novel cluster within the genogroup.
Complete Genome Sequence of the Podoviral Bacteriophage YMC/09/02/B1251 ABA BP, Which Causes the Lysis of an OXA-23-Producing Carbapenem-Resistant Acinetobacter baumannii Isolate from a Septic Patient
Authors: Jeon Jongsoo , Kim Jae-won , Yong Dongeun , Lee Kyungwon , Chong Yunsop 
Published: October 2012

ABSTRACT

The emergence of carbapenem-resistant
Acinetobacter baumannii
, responsible for causing nosocomial infections, has been becoming a significant global health issue. In this article, we report the complete genome sequence of bacteriophage Bϕ-B1251 (YMC/09/02/B1251 ABA BP), which causes lysis of a carbapenem-resistant
A. baumannii
strain. The bacteriophage belongs to the family
Podoviridae
and has a double-stranded circular DNA genome with a length of 45,364 bp and a 39.05% G+C content. Genome analysis showed that it had no similarity to other previously reported bacteriophages capable of infecting
A. baumannii
.
Complete Genome Sequence of the Bacteriophages ECBP1 and ECBP2 Isolated from Two Different Escherichia coli Strains
Authors: Nho Seong-Won , Ha Mi-Ae , Kim Ki-Sei , Kim Tae-Hwan , Jang Ho-Bin , Cha In-Seok , Park Seong-Bin , Kim Young-Kyu , Jung Tae-Sung 
Published: October 2012

ABSTRACT

Escherichia coli
is recognized as one of the most abundant avian bacterial pathogens. In this study, we report the sequencing by the traditional Sanger method of ECBP1 and ECBP2: bacteriophages that infected two different
E. coli
strains which might be used as therapeutic agents in combination with alternative antibiotics.
Genome Sequence of a Novel Hobi-Like Pestivirus in China
Authors: Mao Li , Li Wenliang , Zhang Wenwen , Yang Leilei , Jiang Jieyuan 
Published: October 2012

ABSTRACT
Hobi-like pestivirus is a novel pestivirus species first isolated in 2004. Here, we report the genome sequence of a Hobi-like pestivirus strain isolated from contaminated MDBK cells in China. The sequence information is important for surveillance of this emerging animal infectious disease worldwide.
Genome Sequence of Human Adenovirus Type 55, a Re-Emergent Acute Respiratory Disease Pathogen in China
Authors: Zhang Qiwei , Seto Donald , Cao Bin , Zhao Suhui , Wan Chengsong 
Published: October 2012

ABSTRACT
Human adenovirus type 55 (HAdV-B55) is an acute respiratory disease (ARD) pathogen first completely characterized in China (2006). This is a unique Trojan horse microbe with the virus neutralization attribute of a renal pathogen and the cell tropism and clinical attributes of a respiratory pathogen, bypassing herd immunity. It appeared to be an uncommon pathogen, with earlier putative, sporadic occurrences in Spain (1969) and Turkey (2004); these isolates were incompletely characterized using only two epitopes. Reported here is the genome of a second recent isolate (China, 2011), indicating that it may occur more frequently. The availability of this HAdV-B55 genome provides a foundation for studying adenovirus molecular evolution, the dynamics of epidemics, and patterns of pathogen emergence and re-emergence. These data facilitate studies to predict genome recombination between adenoviruses, as well as sequence divergence rates and hotspots, all of which are important for vaccine development and because HAdVs are used for epitope and/or gene delivery vectors.
Complete Genome Sequence of a Novel Reassortant H11N2 Avian Influenza Virus Isolated from a Live Poultry Market in Eastern China
Authors: Zhang Yuee , Teng Qiaoyang , Ren Chaochao , Li Guoxin , Li Xuesong , Li Zejun 
Published: October 2012

ABSTRACT
A/chicken/Nanjing/908/2009(H11N2) (CK908) was isolated from a live poultry market in Nanjing, China. Using PCR and sequencing analysis, we obtained the complete genome sequences of the CK908 virus. The sequence analysis demonstrated that this H11N2 virus was a novel reassortant AIV whose PB1, PB2, PA, HA, NP, NA, M, and NS genes originated from H9N2, H7N7, H5N2, H11N8, H3N6, H6N2, H1N1, and H5N1, respectively. Knowledge regarding the complete genome sequences of the CK908 virus will be useful for epidemiological surveillance.
Complete Genome Sequence of a Novel Bovine Norovirus: Evidence for Slow Genetic Evolution in Genogroup III Genotype 2 Noroviruses
Authors: Mauroy A. , Scipioni A. , Mathijs E. , Ziant D. , Daube G. , Thiry E. 
Published: October 2012

ABSTRACT
A new genogroup III genotype 2 bovine norovirus, B309/2003/BE, was entirely sequenced and genetically compared to the original Newbury2/1976/UK strain and to Dumfries/1994/UK, detected in 1976 and 1994, respectively. Interestingly, except in well-defined coding regions (N-terminal protein, 3A-like protease, hypervariable region of the capsid protein, and C-terminal part of the minor structural protein), very low genetic differences were noted between the entire genomes of these three strains along a 30-year-long period. It allowed some hypotheses of hotspots of genetic evolution through a low genetic evolution background in genotype 2 genogroup III bovine noroviruses.
Complete Genome Sequence of a Porcine Orthoreovirus from Southern China
Authors: Dai Yimin , Zhou Qingfeng , Zhang Chengwen , Song Yanhua , Tian Xiaoyan , Zhang Xiangbin , Xue Chunyi , Xu Shun , Bi Yingzuo , Cao Yongchang 
Published: October 2012

ABSTRACT

Porcine orthoreoviruses belong to the family
Reoviridae
and cause mainly mild enteritis in piglets. We present here the complete genome sequence of a novel porcine orthoreovirus strain (GD-1) isolated from a piglet in southern China. Our data will facilitate future investigations of the molecular characteristics and epidemiology of porcine orthoreoviruses.
Complete Genome Sequence of Temperate Bacteriophage
Aca
ML1 from the Extreme Acidophile Acidithiobacillus caldus ATCC 51756
Authors: Tapia Pablo , Flores Francisco Moya , Covarrubias Paulo C. , Acuña Lillian G. , Holmes David S. , Quatrini Raquel 
Published: October 2012

ABSTRACT

Development of reproducible genetic tools in the industrially important acidithiobacilli is urgently required. Inducible temperate phages which may be modified
in vitro
, propagated in suitable hosts, and used to transduce relevant genetic information to other strains and/or species are potentially valuable tools in this field of research. In order to address these current limitations, the genome sequence of an inducible temperate
Myoviridae
-like bacteriophage from the
Acidithiobacillus caldus
type strain was annotated and analyzed bioinformatically. Here, we announce the genome sequence of
Aca
ML1 and report major findings from its annotation.
Complete Genome Sequences of Highly Divergent Torque Teno Virus Type II from Swine Herds
Authors: Wang Meng-meng , Zhou Yan-jun , Zhang Qing-zhan , Hou Jun-wei , Yu Hai , Tong Guang-zhi 
Published: October 2012

ABSTRACT

Through routine and nested PCR amplifications, four complete genome sequences of porcine
Torque teno virus
(TTV) type II were obtained from swine herds. By comparison with the TTV genome sequences deposited in GenBank, we found the most divergent types so far described. The level of genetic diversity between these genomes is higher than would be expected within a single virus species. A nucleotide and amino acid phylogenetic tree was constructed.