bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sodium–glucose co-transporter-2 inhibitors - empagliflozin and dapagliflozin as future therapy for Alport Syndrome, literature review
Authors: Kłusek Magdalena , Chawrylak Katarzyna , Kuszneruk Julia , Kubas Maria , Krzemińska Katarzyna 
Published: July 2024

Introduction and purposes:
Alport syndrome (AS) is a common hereditary kidney disorder for which there is currently no curative treatment. The current standard of care for AS involves therapeutic blockade of the renin-angiotensin-aldosterone system (RAAS). This review explores the potential of sodium-glucose co-transporter-2 (SGLT2) inhibitors (SGLT2i) as a treatment option that may slow the progression of chronic kidney disease (CKD) and prevent the advancement to end-stage kidney disease (ESKD).
Materials and Methods:
A systematic literature search was conducted using PubMed and Google Scholar, employing the following search terms: 'Alport syndrome,' 'SGLT2' 'inhibitors,' ‘sodium-glucose transporter 2 inhibitors’, 'proteinuria,' 'albuminuria,' 'empagliflozin,' 'dapagliflozin.' Articles published between 2019 and 2024 were included in the search.
Results:
Recent randomized clinical trials have shown that SGLT2i have nephroprotective effects in CKD. SGLT2i may effectively address the hemodynamic overload in addition to RAAS-blockade in AS patients, potentially delaying end-stage renal failure (ESRF) by several years. Studies indicate that empagliflozin and dapagliflozin are well tolerated and significantly reduce proteinuria in patients with AS. However, they may also cause an initial decrease in estimated glomerular filtration rate (eGFR), raising some safety concerns. This highlights the importance of monitoring and evaluating the treatment course in every AS patient starting SGLT2i therapy.
Conclusion:
Our findings contribute to the growing evidence that SGLT2i reduce proteinuria and may slow disease progression. They could become a future standard of care for patients with glomerular kidney diseases like AS. Future research should investigate the earlier use of SGLT2i in treatment and monitor long-term outcomes in treated patients.
Physical activity during postpartum period - an analysis of the latest studies and guidelines
Authors: Chawrylak Katarzyna , Kubas Maria , Krzemińska Katarzyna , Kuszneruk Julia , Kłusek Magdalena 
Published: July 2024

Introduction and Purpose:
Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity weekly for postpartum women to enhance cardiovascular fitness, muscle strength, weight management, and mental health, particularly in alleviating postpartum depression (PPD). This review aimed to overview physical activity (PA) in postpartum women and identify key aspects to improve their health and quality of life.

Methods:
A literature review was conducted using PubMed and Google Scholar, focusing on articles from 2015 to 2024, including observational studies, clinical trials, meta-analyses, and systematic reviews. Non-English articles and book chapters were excluded.

State of Knowledge:
Studies highlighted the effectiveness of various exercise regimens for postpartum conditions. Trunk stabilization exercises significantly reduced lumbopelvic pain and disability. Exercise training impacted maternal vascular health and blood pressure, with regular exercise reducing blood pressure, preventing long-term cardiovascular diseases. Innovative approaches, such as progressive muscle relaxation exercises (PMRE) combined with online health counseling, reduced PPD and enhanced maternal attachment. Smartphone app-based pelvic floor muscle training (PFMT) reminders increased adherence and improved short-term pelvic floor muscle (PFM) function, showing potential long-term benefits.

Summary:
This review provides strong evidence for structured PA programs in postpartum care, offering benefits from pain reduction and improved cardiovascular health to enhanced mental well-being. Future research should identify barriers to PA adherence and develop tailored interventions for postpartum women.
Nutritivne intervencije u zbrinjavanju djeteta s dijagnozom malignog tumora
Authors: Mišak Zrinjka , Sila Sara 
Published: July 2024

Introduction: Nutrition is of great importance in the treatment of malignant diseases because the nutritional status affects the outcome of the disease itself, the tolerance of chemotherapy and the overall survival and quality of life. This is especially important in childhood when, in addition to the treatment of the underlying disease, it is necessary to ensure the normal growth and development of the child.
Objective: The aim of this paper was, based on a review of the literature, to point out the importance and show the basics of nutritional assessment and monitoring, as well as nutritional interventions in children suffering from malignant diseases.
Methods: The available scientific and professional literature (PubMed) for the last 10 years was searched, and the following keywords were used: nutrition, malignant disease, diet, nutritional assessment, and nutritional intervention. All received abstracts were screened and selected were publications that included above keywords as a main topic.
Results: Based on the reviewed literature, presented are the basics of nutritional assessment and when to perform it, risks for nutritional disorders and available nutritional interventions.
Conclusion: In pediatric oncology patients, it is important to carry out a nutritional assessment not only at the time of diagnosis, but also during the further course of treatment and follow-up of the patient, to determine individual nutritional interventions that will prevent or treat an already occurring nutritional disorder, and to ensure the growth of the child in accordance with the genetic potential.
Pharmacogenetic profiling of paediatric oncology patients: a single-centre experience
Authors: Kranjčec Izabela , Rešić Arnes , Buljan Domagoj , Rajačić Nada , Pavlović Maja , Matijašić Stjepović Nuša , Jadrijević Cvrlje Filip , Bonevski Aleksandra , Jakovljević Gordana , Stepan Giljević Jasminka 
Published: July 2024

Aim: As the results of pharmacogenetic studies are increasingly translated into clinical practice, the ultimate goal of personalising treatment for children with cancer seems achievable in the future. Our survey aimed to establish to what extent pharmacogenetics has already been utilised in everyday work.Methods: A retrospective survey on pharmacogenetic testing in children treated for malignancies at the Department of Oncology and Haematology, Children’s Hospital Zagreb, from 2021 to 2023 was carried out.Results: Pharmacogenetic testing was performed in 17.2% of the 180 children (53.3% female, median age 7.0 years), the greatest number of tests obtained in 2023. Preemptive testing included thiopurine S-methyltransferase polymorphisms (in 94.4% of children with acute lymphoblastic leukaemia and 33.3% with eosinophilic granuloma) and methylenetetrahydrofolate reductase gene poly-morphisms assaying (in 55.6% of acute lymphoblastic leukaemia and 23.1% of osteosarcoma patients). In 8 children, pharmacogenetic testing was made due to adverse events (25% lung and 75% liver injury, all grade 4), in the majority of cases presumably related to vincristine. Pharmacogenetic testing results were pathological in all reactively tested patients, requiring dose modification/chemotherapeutics omission in 87.5% of cases.Conclusion: The number of pharmacogenetic assays performed due to high-grade adverse events in children with cancer has been continuously rising, steering otherwise standardised treatment towards a more individualised approach. Preemptive thiopurine Methyltransferase Polymorphism testing has been routinely done in almost all patients planned to receive thiopurines. However, more research is needed on drug-gene pairs in the field of paediatric oncology to minimise treatment-related toxicity and optimise treatment outcomes.
Gastric Signet Ring Cell Adenocarcinoma With Metastasis to the Testicles and Leptomeninges
Authors: Shariff Hamzah , Luu Tristan , Kavis Haluk , Obuch Joshua 
Published: July 2024

ABSTRACT
Gastric signet ring cell adenocarcinoma (SRCA) is an aggressive malignancy primarily diagnosed in advanced stages. Metastasis to other organ systems is uncommon, however, associated with poor prognosis. We present a young patient with persistent pain in the testicle. Histopathologic examination of the resected testicle revealed metastatic signet ring adenocarcinoma prompting follow-up endoscopy with biopsy confirming gastric SRCA. After 10 months of systemic chemotherapy, the patient developed worsening headaches, and cerebrospinal fluid cytology confirmed leptomeningeal metastasis. This case underscores the rare manifestation of SRCA and the importance of vigilance for atypical presentations to ensure timely diagnosis and management.
Unresectable Metastatic Solid Pseudopapillary Pancreatic Neoplasm Treated With Liver Transplantation
Authors: Pace Jordan L. , Hopstone Michelle D. , Conti Peter S. , Tom Chloe , Mohamed Passant , Gong Yuna , Karne Vidyadhari , Genyk Yuri , Kaur Navpreet , Kahn Jeffrey A. 
Published: July 2024

ABSTRACT
We present a 49-year-old woman requiring living donor liver transplantation after liver metastasis from a pancreatic solid pseudopapillary tumor. After identifying a pancreatic mass and liver lesions, she underwent extensive surgical resection. Pathology revealed a solid pseudopapillary neoplasm of the head and body of the pancreas, extending into the peripancreatic soft tissues and confirmed to have spread to the liver. Subsequently, she underwent adjuvant chemotherapy and radiofrequency ablations of the new liver lesions. Despite immunotherapy and chemotherapy, there was a progression of the lesions. With interval growth of liver lesions, without evidence of extrahepatic disease, she underwent living donor liver transplantation.
Development of a Telepresence Robot with Integration of a General Practice Medical Consultation Module
Authors: Carranza Karmelo Antonio Lazaro R. , Day Nicole Jillian B. , S. Lin Lawrence Matthew , Ponce Albert R. , Reyes Wilbur Rex O. , Abad Alexander C. , Baldovino Renann G. 
Published: July 2024

The Philippines is facing a major problem in the healthcare industryâ€”the maldistribution of doctors. This greatly affects peopleâ€™s accessibility to proper healthcare; in fact, in 2015, 59.2% of deaths in the Philippines are attributed as deaths unattended by a doctor. One viable solution to this problem is the use of telepresence robots, as doctors can still provide quality healthcare services even when located in remote areas.Â The researchers developed a mobile telepresence robot integrated with different physical examination equipment used in general practice medical consultation, which are an otoscope with a tested average video delay of 3.76s over VPN, a stethoscope with 5.19s audio delay (LAN), and an ultrasound probe with 6.32s video delay (LAN). The teleconsultation system also consists of a web-based application, which serves as a medium for the duplex communication, remote robot control, patient database access, and transmission of media footage captured by the physical examination devices. The developed web-based application had an overall relative efficiency of 93.58% and a System Usability Scale Score of 82.5, when used by invited medical professionals. The researchers believe that this will extend the reach of medical doctors to rural areas and improve the overall health conditions in these communities.
Optimized Bayesian NL-means Blockwise approach for Ultra Sound Images
Authors: Ahmed Mohammed Saleem , Korandla Raju , Prasad SNVASRK , Gopatoti Anandbabu 
Published: July 2024

Ultrasound imaging is a portable medical diagnostic tool provides real time clear images of soft tissues compared to x-ray imaging in which tissues are not visible up to the mark. Other diagnostic tools like Magnetic Resonance Imaging and Computer Tomography can well visualize the tissues but are cost effective.Â Due to the presence of speckle noise Ultrasound images gets degraded leads to low quality imaging. This noise down the spatial, contrast resolutions and Peak Signal to Noise Ratio (PSNR) in US images. Consequently, filtering techniques for speckle noise reduction are of unique interest for clinical ultrasound imaging.
An Enhanced Salted Challenge Response Authentication Mechanism (scram) for Secret Key Authentication and File Sharing Process in Cloud Storage
Authors: Qatan Atif M. , Ph.D 
Published: July 2024

In the present digital world, different types of organization generate a huge volume of sensitive data comprising with financial data, health records, electronic health records, personal information and so on. The volume of digital data is tremendously improving at a staggering rate and it is expanding almost each and every yearÂ and outperforming the ability of storage restriction. These data often required to be stored at multiple locations for a long time because of the regulatory compliance and operational purposes. The local management of such great volume of cloud data is costly as well as problematic because of the needs of qualified personnel capability and great storage capacity. While there is a secure drop in the cost of the storage management and hardware storage, cost has become more complex. The Storage-as-a-Service (SaaS) provided by CSPs is a developing solution to lessen the load of huge local data storage and data maintenance cost in terms of outsourcing data storage. In the scenario of outsourcing data, the organization delegates the management and storage of their data to a CSP in the exchange of already declared fees and it has been metered in GB per month. The number of outsourced data is stored on the remote server instead of using private computer systems. This research paper concentrates to provide secure cloud auditing process within the multiple groups of users. In addition this improves the data integrity, provable security and data recovery process. Thus it minimizes the communication complexity and storage cost. The proposed research work based on Enhanced Salted Challenge Response Authentication Mechanism (SCRAM) which is used for secret key authentication and sharing process.
Alpha Lactose Monohydrate Morphology: Molecular Modelling and Experimental Approach
Authors: Lukman Zulfahmi , Anuar Nornizar , Fitrah Abu Bakar Noor , Abdul Rahman Norazah 
Published: July 2024

This study is conducted to investigate morphologies ofalpha lactose monohydrate (Î±LM) grown in polyethylene glycol 300 (PEG 300) solution and vacuum condition via molecular modelling techniques. Surface chemistry of predicted Î±LM is described. The molecules of Î±LM in its unit lattice were optimized prior to morphological prediction of attachment energy method and the suitable potential function was determined. The predicted lattice energy of Î±LM was in excellent agreement with the experimental lattice energy with percent errors of 3.9%. The morphology of Î±LM is predicted to be hexagonal in shape, similar to crystal morphology of Î±LM grown in PEG 300 solutions. It was found that the lattice energy and of Î±LM was dominated by the weak van der Waals force.Â Â
An Efficient Assistive Solution for Elderly Dementia Care
Authors: Jeeva A. , Gayathri K. , Arulselvi S. , Rajesh K. 
Published: July 2024

Aging population is becoming a major concern of human society in the recent years. Elderly people suffering from Alzheimer and dementia have cognitive declines making them difficult in remembering landmarks in their outdoor navigational tasks. Therefore, disorientation and wandering become common for elderly people even in their familiar environments. Providing assistive guidance to such elders is a challenging task for caretakers as most of the elders prefer to live independently. Thus, there arises a need for detecting the disorientation of the elders in their outdoor navigation and alerting the caretakers in the account of either disorientation or wandering being detected. Further, elderly people can be provided with navigational assistance by mining through their previous historical trajectories and suggesting a location to which the elder has frequently visited at the time when the disorientation had been detected. In addition, a tool can be developed to analyse the level of cognitive decline by identifying the frequencies of different types of wandering patterns that might help to provide effective medication in the treatment of cognitive decline and guidance.Â Â
Upper Limit Superior and Lower Limit Inferior of Soft Sequences
Authors: Hasan Hameed Ahmed , Annon Mousa Ekhlas , Abdullah hamad Abdulsattar , . . 
Published: July 2024

In this paper we have provided some of evidence work of the authors R.N.Hasan, O.A Tantawy in 2016 [1] thy given proof of the concept between two bound soft sets & subsets of soft elements real numbers also was concluded an upper bound and lower bound by using two sequences of soft element real numbers which isÂ Â In this paper, supposed to extend R.N.Hasan, O.A Tantawy work but here we are given new notion and proof for upper limit superior and lower limit inferior with two sequences and subsequences for the conclude new proof after recalled that, which is upper limit superior and lower limit inferior By this we have proved above new two theorems and one proposition & strengthen the example.AMS Subject Classification: 06D72, 40A05, 54A40Â Â
Study of Different Features and Classifiers for Image Retrieval
Authors: Mahajan Arpana , Chaudhary Sanjay 
Published: July 2024

With the advent of multimedia and imaging technology, lots ofÂ Â images sharing and uploading over the internet have been increased. It instigated development of potential image retrieval system to satisfy the requirement of mankind. The content-based image retrieval (CBIR) system retrieves the desired image by low level features similar to color, shape and texture which are not enough to explain the userâ€™s high level perception for images. Therefore reducing this semantic gap problem of image retrieval is challenging task. Some of the concepts in image retrieval are keywords, conditions or text. Conditions are used by human to explain their information need and it also used by system as a way to stand for images. Here in this paper different types of features their advantage and disadvantages are described.Â Â
A New Scheme of Representing a Secret Message Using Second Quotient Remainder Theorem in Text Steganography
Authors: Osman Baharudin , Yasin Azman , Nizam Omar Mohd 
Published: July 2024

Steganography is a method of concealing a secret message in a cover medium in such a way that the intruder is not able to detect the existence of the secret message. Due to extensive use of Internet and other communications media, the confidentiality and data integrity need a special means to protect it against unauthorized access. Several schemes were introduced by researchers to represent the value of a hidden message. The first scheme converts a secret message to ASCII code and is represented into x,y form which raises a redundancy representation for a repeating character of the secret message. The second scheme is using the octal value of secret message and converts it into a similar form. Another scheme modifies the previous scheme by adding a â€œ+â€ and â€œ-â€œsymbols. These techniques are resulted in the limited range of the x,y values, repeating representation and a difficulty on generating a stegotext. To overcome the problems, the proposed scheme represents a secret message with a various representation and converts it into x, y, z form. A Second Quotient Remainder Theorem is used to converts the value to x, y, z forms. As a result, the range of the new representation is increased.Â Â
FEA Analysis of S-PMSG for Aircraft Application
Authors: Thangaraj Bharathi , Arumugam Deepak , Somasundaram Gomathi 
Published: July 2024

In this work the performance analysis of Spoke type Permanent Magnet Synchronous Generator (S-PMSG) also called buried type PMSG is presented for aircraft application. The analytical design of the generator is carried out using design equations and it is verified by RMxprt software. The simulation analysis of the generator is performed by finite element analysis software. The coupled transient electromagnetic field and thermal analysis of the generator is carried out to find the load voltage, load current, cogging torque, heat generation and thermal heat flow. Finally, the overall performance of the analytically designed generator is compared with the simulation results.Â Â
Data Privacy and Confidentiality in Data Breach on Cloud Computing
Authors: Shahzad Faisal , Din Roshidi , Ghazali Osman 
Published: July 2024

The preservation of data security in cloud environment has been identified as one of the key challenges in the field of cloud computing. The breach of data privacy and confidentiality has decreased the shift of enterprises to the cloud environment. However, there is currently no single definition of the concepts of data privacy and data confidentiality that could be generalized. Existing definitions of data privacy and confidentiality are complex, ambiguous and interchangeably used. This lack of clarity leads to confusion and potentially to ineffective and inefficient efforts to secure privacy and confidentiality of data from breach. The aim of this study is threefold. Firstly, this paper tends to explores the existing definitions of data privacy and data confidentiality in cloud computing. Secondly, it purports to examine the association of data breach with data privacy and confidentiality. Lastly,it proposes new operational definitions in order to differentiate between the concepts of data privacy and data confidentiality and data breach. The studies suggested that the concept of data privacy and data confidentiality in cloud computing is closely related and both are prone to breach within cloud security domain. Therefore, devising strategies and techniques to secure privacy and confidentiality of data can ultimately results in reduction of data breach.Â Â
Investigating Issues and Challenges in Utilising WAQF Property
Authors: Abd Mutalib Hasyeilla , Maamor Selamah 
Published: July 2024

Waqf property which is a proper, efficient, well managed and organized will give a positive impact to the community especially on socio-economic aspect. Besides, it will also portray the optimum utilisation of the waqf property by the mutawalli in upholding their responsibility. In Malaysian scenario, waqf property is managed and administered by the State Islamic Religious Council (SIRC) who is acting as a sole trustee at the state level. Currently, there are 14 SIRCs who play their role in managing and administering the waqf property. Even though each SIRC plays its role, there are still unutilised waqf property due to several issues and challenges. Therefore, the purpose of this paper is to reveal the issues and challenges faced that lead to the unutilised of waqf property. A qualitative method is employed in this study using library search as well as semi structured interview on the selected SIRC in the Northern Region of Malaysia as a case study. The study revealed that there are four main issues and challenges that contribute to the unutilised of the property such as non-strategic of waqf property location, lack of fundraise, building orientation which is not suitable, and lack of infrastructure and facilities. The findings of this study are hoped to contribute towards better utilisation of waqf property planning for the benefits of ummah social-economy.Â Â