bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic resection for retroperitoneum ganglioneuroma with Supine hypotension syndrome
Authors: Sugai Yu , Yamoto Masaya , Obayashi Juma , Tsukui Takafumi , Nomura Akiyoshi , Miyake Hiromu , Fukumoto Koji , Kim Sung-Hae , Sato Daijiro , Iwafuchi Hideto 
Published: August 2024

Abstract
Background
Supine hypotension syndrome (SHS) has been reported to occur due to compression by a giant tumor such as ovarian tumor. We herein report a case of retroperitoneal ganglioneuroma with SHS treated with laparoscopic resection.

Case presentation
The patient was an 11-year-old male with right-sided abdominal pain. He had a pale complexion and tachycardia while falling asleep. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a giant mass lesion (60 × 35 mm) with compression of the inferior vena cava (IVC) and duodenum ventrally and the right kidney caudally. The IVC was flattened by mass compression. Abdominal ultrasonography (US) revealed narrowing of the IVC due to the mass and accelerated blood flow after IVC stenosis in the supine and left lateral recumbent position. His pale complexion and tachycardia while falling asleep was thought to be due to decreased venous return caused by the tumor compressing the IVC, resulting hypotension. 123I-MIBG scintigraphy revealed no abnormal findings. Tumor markers were normal. He was diagnosed with SHS due to a right adrenal gland tumor. The tumor compressed the IVC from the dorsal side, and hemostasis was expected to be difficult during bleeding. Therefore, a guidewire was inserted from the right femoral vein into the IVC for emergency balloon insertion during bleeding. A laparoscopic tumor resection was performed. A histopathological examination confirmed the diagnosis of primary retroperitoneal ganglioneuroma.

Conclusions
The treatment of symptomatic retroperitoneal tumors requires a multidisciplinary approach.
Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma
Authors: Suwattananuruk Piyapan , Yaset Sukanya , Chotipanich Chanisa , Moldes-Anaya Angel , Sundset Rune , Berzaghi Rodrigo , Figenschau Stine , Claes Sandra , Schols Dominique , Rojsitthisak Pornchai , Kranz Mathias , Vajragupta Opa 
Published: August 2024

Abstract
Background
This study aimed to develop a novel positron emission tomography (PET) tracer, [68Ga]Ga-TD-01, for CXCR4 imaging. To achieve this goal, the molecular scaffold of TIQ15 was tuned by conjugation with the DOTA chelator to make it suitable for 68Ga radiolabeling.

Methods
A bifunctional chelator was prepared by conjugating the amine group of TIQ15 with p-NCS-Bz-DOTA, yielding TD-01, with a high yield (68.92%). TD-01 was then radiolabeled with 68Ga using 0.1 M ammonium acetate at 60 °C for 10 min. A 1-h dynamic small animal PET/MRI study of the labeled compound in GL261-luc2 tumor-bearing mice was performed, and brain tumor uptake was assessed. Blocking studies involved pre-administration of TIQ15 (10 mg/kg) 10 min before the PET procedure started.

Results
[68Ga]Ga-TD-01 exhibited a radiochemical yield (RCY) of 36.33 ± 1.50% (EOS), with a radiochemical purity > 99% and a molar activity of 55.79 ± 1.96 GBq/µmol (EOS). The radiotracer showed in vitro stability in PBS and human plasma for over 4 h. Biodistribution studies in healthy animals revealed favorable kinetics for subsequent PET pharmacokinetic modeling with low uptake in the brain and moderate uptake in lungs, intestines and spleen. Elimination could be assigned to a renal-hepatic pathway as showed by high uptake in kidneys, liver, and urinary bladder. Importantly, [68Ga]Ga-TD-01 uptake in glioblastoma (GBM)-bearing mice significantly decreased upon competition with TIQ15, with a baseline tumor-to-background ratios > 2.5 (20 min p.i.), indicating high specificity.

Conclusion
The newly developed CXCR4 PET tracer, [68Ga]Ga-TD-01, exhibited a high binding inhibition for CXCR4, excellent in vitro stability, and favorable pharmacokinetics, suggesting that the compound is a promising candidate for full in vivo characterization of CXCR4 expression in GBM, with potential for further development as a tool in cancer diagnosis.
Selective adsorption of gold ion in wastewater with competing cations by novel thiourea-reduced graphene oxide
Authors: Chen Yu-Jie , Chung Adrienne , Hsi Hsing-Cheng 
Published: August 2024

AbstractIn this study, selective adsorption experiments of Au were carried out using graphene oxide (GO) and thiourea-reduced GO (TU-rGO). Adsorption experiments using Au, Cu, Pb, and Zn were performed with GO and TU-rGO in order to selectively adsorb Au from simulated waste electric and electronic equipment leachate or printed circuit board wastewater. Optimal adsorption conditions were determined, adsorption isotherm models were fitted, and desorption and regeneration experiments were performed. Additionally, GO and TU-rGO were characterized to better understand the material and propose the adsorption and desorption mechanisms for TU-rGO. It was found that TU-rGO could selectively adsorb Au, achieving a high efficiency of 95‒99% at initial Au concentrations of 0.1‒10 mg L−1 with little to no adsorption of Cu, Pb, and Zn. Moreover, the desorption efficiency of Au by ammonium thiosulfate reached 94% with the adsorption efficiency of TU-rGO decreasing from 99 to 78% after five adsorption and desorption cycles. Isotherm adsorption experiments indicated that the Langmuir model better fitted the adsorption of Au than the Freundlich model. This implied that the adsorption process was mainly controlled by monolayer coverage, with a high Au adsorption capacity of approximately 833 mg g−1 for TU-rGO.
Semen in the time of COVID-19: a narrative review of current evidence and implications for fertility and reproductive health
Authors: Ukoaka Bonaventure Michael , Okesanya Olalekan John , Gbuchie Monica Anurika , Daniel Faithful Miebaka , Wali Tajuddeen Adam , Ugorji Winner Chimdindu , Udam Ntishor Gabriel , Abubakar Na’ima Tanimu , Eliseo Don Lucero-Prisno 
Published: August 2024

Abstract
Background
Historically, viruses have impaired the functionality of human systems. The discovery of novel viruses and the resurgence of established strains heighten concerns about their implications for reproduction. In the aftermath of COVID-19, research efforts have intensified to broaden the understanding of the severe acute respiratory syndrome coronavirus-2’s (SARS-CoV-2) effect on male reproduction across diverse populations. Various findings have been reported, with more studies highlighting the adverse impact of SARS-CoV-2 on semen parameters and, consequently, male fertility. This review aims to comprehensively assess and consolidate existing evidence on the impact of SARS-CoV-2 on semen quality and male fertility. It highlights the potential mechanism of action and further underscores the implications for assisted reproductive technology.

Methodology
A thorough literature search was conducted across various electronic databases, including PubMed, Scopus, Google Scholar, Embase, and Web of Science. Studies published between January 2020 and May 2024 were included if they explored the impact of SARS-CoV-2 on semen quality.

Results
Twenty-nine (29) studies were included in the review. These studies varied in findings but delineated a pattern and trend. While most studies noted a decline in sperm parameters—motility, count, concentration—altered morphology, hormonal imbalances, and increased DNA fragmentation in COVID-19 patients, others reported normal semen parameters 3 to 6 months post-recovery. Few studies reported no change in semen parameters, especially with mild disease. Potential mechanisms underscoring these effects include the presence of fever and consequent release of pro-inflammatory cytokines—interleukin 1β, tumor necrosis factor (TNF), and interferon-gamma (IFNγ). In addition, the activities of the angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) receptors have been implicated as gateway mechanisms for viral entry. The long-term consequences and comparisons with other viral infections highlight the complexity of drawing definite conclusions. The different findings on semen changes have implications for assisted reproduction and family planning. Research suggests potential negative effects on gonadal function, emphasizing the need for long-term follow-up studies to understand the persistent effects on male fertility biomarkers.

Conclusion
A multidisciplinary approach is essential to optimizing male reproductive health during and after SARS-CoV-2 infection. This includes incorporating assessments into vaccine safety studies to address fertility concerns.
Cortical auditory evoked potentials in peripheral neuropathy
Authors: Mejahed Mohammad , Ibrahim Amira M. , Haydara Tamer , Ragab Salma , Gabr Takwa A. 
Published: August 2024

Abstract
Background
Cortical auditory evoked potentials (CAEPs) display both auditory processing and neurological activity in the auditory cortex. The purpose of this research is to evaluate the importance of CAEPs in identifying auditory processing disorders in patients with peripheral neuropathy (PN) in different pathologies. Sixty cases with PN of different pathologies represented the study group which was classified into two subgroups according to the underlying pathology of PN: those with either axonal PN (44 patients) and those with demyelinating PN (16 patients). The current study also included a control group of 40 healthy volunteers who did not have any peripheral or central auditory neurological disorders. CAEPs were recorded in both groups.

Results
The study group’s CAEP response showed significantly delayed latencies than the control groups. Comparing the two study subgroups revealed that the axonal PN group had significant delayed latencies of N1 and P2 components in comparison to the demyelinating PN group.

Conclusion
Cortical auditory evoked potentials can be used efficiently to diagnosis central auditory processing disorders in patients with PN. CAEP latencies can be employed alone or in conjunction with amplitudes; however, CAEP latencies are more significant than amplitudes for such purpose. Both demyelinating and axonal PN are associated with impaired auditory processing; however, axonal PN patients are more likely to be affected, suggesting that axonal PN has a significantly drastic effect on the central auditory nervous system.
Impact of Reclassification of Oncocytic and Follicular Thyroid Carcinoma by the 2022 WHO Classification
Authors: Stegenga Merel T , Oudijk Lindsey , van Velsen Evert F S , Peeters Robin P , Medici Marco , Verburg Frederik A , van Ginhoven Tessa M , van Kemenade Folkert J , Visser W Edward 
Published: August 2024

Abstract

Background
The 2022 WHO Classification categorizes oncocytic (OTC) and follicular thyroid carcinoma (FTC), based on the degree of capsular and vascular invasion, into minimally invasive (MI), encapsulated angio-invasive (EA), and widely invasive tumors (WI). While associations with clinical outcomes have been studied extensively in FTC, robust clinical data are lacking for OTC. We aimed to investigate the impact of the reclassification of OTC and FTC by the 2022 WHO Classification on clinical outcomes.

Methods
All adult OTC and FTC patients treated at the Erasmus MC (the Netherlands) between 2000 and 2016 were retrospectively included. All tumors were extensively revised by 2 independent pathologists, facilitated by Palga: Dutch Pathology Databank. Kaplan-Meier curves were used to study the association of the 2004 and 2022 WHO Classification with overall survival, disease-specific survival (DSS), recurrence-free survival, and radioactive iodine (RAI)-refractory disease.

Results
Among 52 OTC and 89 FTC patients, 15 (28.8%) OTC and 34 (38.2%) FTC tumors were reclassified as EAOTC or EAFTC. The 2022 WHO Classification substantially improved risk stratification in both subtypes for DSS, compared to the 2004 edition. Ten-year DSS rates were 100% for MIOTC, 92.9% for EAOTC, and 56.5% for WIOTC, compared to 100% (MIOTC) and 64.2% (WIOTC) following the 2004 WHO Classification. For FTC and RAI-refractory disease, similar trends were observed.

Conclusion
Classification of OTC and FTC into 3 subcategories as defined by the 2022 WHO Classification substantially improves discrimination between low-, intermediate-, and high-risk patients, especially for DSS and RAI-refractory disease.
The Transtemporal Isthmus Approach for Insular Glioma Surgery
Authors: Sun Guochen , Shu Xujun , Wu Dongdong , Zhao Kai , Xue Zhe , Cheng Gang , Chen Ling , Zhang Jianning 
Published: August 2024

BACKGROUND AND OBJECTIVES:
Maximal and safe removal of insular gliomas by a transinsular cortex approach is challenging. In this article, a new transtemporal isthmus approach to resect insular gliomas is presented.

METHODS:
We retrospectively examined 53 patients with insular glioma who underwent resection through the temporal isthmus approach using magnetic resonance imaging and functional neuronavigation guidance and intraoperative electrophysiological monitoring. Extent of resection was determined using intraoperative magnetic resonance imaging.

RESULTS:
Fifty-three patients were included for analysis, 30 men and 23 women. The median (range) age was 45 (26-70) years. Tumor laterality was left in 22 patients and right in 31. All tumors involved at least zone III or IV (Berger-Sanai classification system), including zones I-IV were involved in 29 (54.7%) and zones III and IV in 17 (32.0%). Among the 37 low-grade gliomas, preoperative median (IQR) volume was 45.7 (31.8, 60.3) cm3, and gross total resection was achieved in 24 (64.9%). Among the 16 high-grade gliomas, preoperative median (IQR) volume was 45.3 (40.1, 54.0) cm3, and gross total resection was achieved in 14 (87.5%). The median (IQR) extent of resection of the whole group was 100% (89%-100%). The median (IQR) postoperative Karnofsky performance score 3 months after surgery was 90 (80-90). Mean temporal isthmus width was significantly higher in the affected side (involving tumor) than the contralateral one (21.6 vs 11.3 mm; 95% CI: 9.3 to 11.3, P < .01). Muscle strength was grade 4 or higher, and speech was nearly normal in all patients 3 months after surgery.

CONCLUSION:
Insular glioma surgery using the transtemporal isthmus approach can achieve safe and maximum resection. A widened temporal isthmus provides a surgical pathway for transisthmic resection of insular tumor.
Metabolic Heat Production Modulates the Cardiovascular Drift–V̇O2max Relationship Independent of Aerobic Fitness in Women
Authors: STONE TORI , BURNASH SARAH G. , EARLEY RYAN L. , MULHOLLAND ANNIE M. , YODER HILLARY A. , MACDONALD HAYLEY V. , RICHARDSON MARK T. , WINGO JONATHAN E. 
Published: August 2024

ABSTRACT

Introduction/Purpose
The purpose of this study was to test the hypothesis that cardiovascular (CV) drift and associated decrements in maximal oxygen uptake (V̇O2max) are greater in high-fit compared with low-fit women during exercise at the same %V̇O2max, but comparable at the same rate of metabolic heat production.

Methods
Six high-fit (HI) and six low-fit (LO) women cycled in 35°C for 15 or 45 min at the same relative intensity (60% V̇O2max; 15REL and 45REL) or fixed rate of heat production (500 W; 15FX and 45FX), immediately followed by a graded exercise test to measure V̇O2max. The separate 15- and 45-min trials permitted measurements of V̇O2max over the same time interval as CV drift.

Results
During 45REL, higher heat production in HI (496 ± 51 vs 364 ± 44 W in LO) resulted in greater end-exercise core temperature (38.7°C ± 0.4°C vs 38.2°C ± 0.1°C, P = 0.03), greater increases in HR (15 bpm (10%) vs 10 bpm (6%), P = 0.03) and decreases in stroke volume (11 mL per beat (16%) vs 5 mL per beat (8%), P = 0.001), and larger reductions in V̇O2max (16% vs 5%, P = 0.04) compared with LO. During 45FX, temperature responses, CV drift, and decreased V̇O2max were not different between groups (all P > 0.05), despite differences in %V̇O2max (60% vs 75% for HI and LO, respectively).

Conclusions
We conclude metabolic heat production modulates the CV drift–V̇O2max relationship, independent of fitness level. These results support previous findings showing the magnitude of CV drift is proportional to reductions in V̇O2max.
A Game-Theoretic Framework for Generic Second-Order Traffic Flow Models Using Mean Field Games and Adversarial Inverse Reinforcement Learning
Authors: Mo Zhaobin , Chen Xu , Di Xuan , Iacomini Elisa , Segala Chiara , Herty Michael , Lauriere Mathieu 
Published: August 2024

A traffic system can be interpreted as a multiagent system, wherein vehicles choose the most efficient driving approaches guided by interconnected goals or strategies. This paper aims to develop a family of mean field games (MFG) for generic second-order traffic flow models (GSOM), in which cars control individual velocity to optimize their objective functions. GSOMs do not generally assume that cars optimize self-interested objectives, so such a game-theoretic reinterpretation offers insights into the agents’ underlying behaviors. In general, an MFG allows one to model individuals on a microscopic level as rational utility-optimizing agents while translating rich microscopic behaviors to macroscopic models. Building on the MFG framework, we devise a new class of second-order traffic flow MFGs (i.e., GSOM-MFG), which control cars’ acceleration to ensure smooth velocity change. A fixed-point algorithm with fictitious play technique is developed to solve GSOM-MFG numerically. In numerical examples, different traffic patterns are presented under different cost functions. For real-world validation, we further use an inverse reinforcement learning approach (IRL) to uncover the underlying cost function on the next-generation simulation (NGSIM) data set. We formulate the problem of inferring cost functions as a min-max game and use an apprenticeship learning algorithm to solve for cost function coefficients. The results show that our proposed GSOM-MFG is a generic framework that can accommodate various cost functions. The Aw Rascle and Zhang (ARZ) and Light-Whitham-Richards (LWR) fundamental diagrams in traffic flow models belong to our GSOM-MFG when costs are specified. History: This paper has been accepted for the Transportation Science Special Issue on ISTTT25 Conference. Funding: X. Di is supported by the National Science Foundation [CAREER Award CMMI-1943998]. E. Iacomini is partially supported by the Italian Research Center on High-Performance Computing, Big Data and Quantum Computing (ICSC) funded by MUR Missione 4-Next Generation EU (NGEU) [Spoke 1 “FutureHPC & BigData”]. C. Segala and M. Herty thank the Deutsche Forschungsgemeinschaft (DFG) for financial support [Grants 320021702/GRK2326, 333849990/IRTG-2379, B04, B05, and B06 of 442047500/SFB1481, HE5386/18-1,19-2,22-1,23-1,25-1, ERS SFDdM035; Germany’s Excellence Strategy EXC-2023 Internet of Production 390621612; and Excellence Strategy of the Federal Government and the Länder]. Support through the EU DATAHYKING is also acknowledged. This work was also funded by the DFG [TRR 154, Mathematical Modelling, Simulation and Optimization Using the Example of Gas Networks, Projects C03 and C05, Project No. 239904186]. Moreover, E. Iacomini and C. Segala are members of the Indam GNCS (Italian National Group of Scientific Calculus).
Mohs micrographic technique in high-risk basal cell carcinoma: a 3D prediction of safety margins
Authors: Cammarata Edoardo , Esposto Elia , Airoldi Chiara , Giorgione Roberto , Boggio Paolo , Savoia Paola 
Published: August 2024

Objective: Compared with standard excision with a two-dimensional histological examination, Mohs micrographic surgery offers a lower recurrence rate and a greater extent of healthy tissue sparing for the treatment of high-risk basal cell carcinoma (BCC). The aims of this study were to first quantify the healthy tissue spared through the micrographic technique compared to traditional surgery for high-risk tumours. Then, to speculate, through the analysis of the distal micrographic resection margin, the adequate width of safety margins for standard excision. Method: A cohort of patients with high-risk BCC was treated with Mohs surgery. Safety margins, tumours residual final breach and hypothetical standard excision safety margins areas were recorded. Results: A total of 96 patients were included. A reduction of 27.96% (95% Confidence Interval (CI): 17.90–38.02) of healthy skin removed was observed using a micrographic method compared to the standard approach. Standard excision with a 6mm safety margin was associated with 86.46% (95% CI: 79.62–93.30) of complete excision. Greater margins were not associated with a statistically significant improvement of complete excision. Conclusion: Mohs surgery should be considered the gold standard operative treatment for high-risk BCC. However, if micrographic techniques are not feasible, the standard excision with a predetermined margin of 6 mm, should be considered as the best option.
Compromiso empresarial frente a procesos de gestión de proyectos, estudio de caso en las pymes de Pasto (Colombia)
Authors: Delgado Bolívar Arturo , Gómez Hugo Fernando Ceballos 
Published: August 2024

La gestión de proyectos asociada con procesos de iniciación, planeación, ejecución, monitoreo, control y cierre, apoyan la administración del tiempo y costos; por tanto cambios y/o retrasos en áreas específicas afectan el proyecto, más aún teniendo en cuenta dificultadas comunes que enfrentan empresarios de pequeñas y medianas empresas, resumidas por Okpara y Winn (2017), en cuatro áreas: 1) administrativa, 2) operativa, 3) factores externos y 4) estratégica. Por otro lado, Arturo & Díaz (2021), Mazurkiewicz (2018), dan cuenta de la ausencia de gestión de proyectos en empresas pymes, originado por recursos escasos, desconocimiento, falta de formación y práctica en la disciplina. Para llenar este vacío, este documento sugiere, a partir de los bajos niveles de compromiso detectados, generar propuestas de gestión organizacional. El investigador utilizó el paradigma cuantitativo y busca determinar el compromiso empresarial en la aplicación de procesos de gestión de proyectos, a partir de 10 escenarios.