bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of histologically poorly cohesive phenotype as a prognostic factor in patients with pStage II/III gastric cancer undergoing adjuvant chemotherapy
Authors: Kunisaki Chikara , Sato Sho , Kasahara Kohei , Sato Tsutomu , Yago Akikazu , Tamura Yuko , Oshi Masanori , Kosaka Takashi , Akiyama Hirotoshi , Endo Itaru 
Published: August 2024

Abstract

Purpose
We evaluated the impact of histological type to evaluate prognostic factors after adjuvant chemotherapy (AC) in patients with pStage II and III gastric cancer.
Methods
Overall, 384 patients with pStage II and III gastric cancer undergoing R0 gastrectomy were included. Of these, 143 underwent AC. Univariate and multivariate analyses for prognostic factors of relapse-free survival (RFS) and overall survival (OS) were performed.
Results
Multivariate analysis revealed that macroscopically ill-defined type, histologically poorly cohesive carcinoma with not otherwise specified and signet ring cell subtype (PCC-NOS/SRC) and pStage III independently and adversely affected RFS. Alternatively, male sex, macroscopically ill-defined type, less D2 lymph node dissection and pStage IIB and III independently and adversely affected OS. In multivariate analysis of patients receiving AC, histological phenotype and tumour diameter independently influenced RFS. Compared with NON-PCC, PCC-NOS/SRC showed worse RFS, whereas SRC showed favourable RFS. Moreover, tumour diameter ≥ 80 mm showed worse RFS. Multivariate analysis for OS in patients undergoing AC revealed similar results.
Conclusion
Histologically PCC-NOS/SRC type and tumour diameter of ≥ 80 mm indicated poor survival even after AC in patients with pStage II and III gastric cancer. An effective therapeutic regimen needs to be developed for such histological subtypes.
Experimental Study on Unique Interactions in Steel Pipe Sheet Piles Under Lateral Load: Joint, Pipe, and Soil
Authors: Peng Junxiong , Miyazaki Yuusuke 
Published: August 2024

Abstract

The steel pipe sheet pile (SPSP) foundation has been developed and applied as a dual-use structure for temporary coffering and bridge foundations in Japan since the 1960s. Mechanical complexity occurs essentially in the joint part for which each steel pipe is a coupled structure. This paper tries to experimentally explain how the pipe-joint-soil interaction (PJSI) influences the lateral load-displacement curve of the SPSP foundation. PJSI has mainly been discussed through finite element (FE) analyses due to the difficulty of creating experimental models that realize both geometric and mechanical similarities to prototypes. This study introduces a centrifugal model of SPSPs in which the joint filling material is modeled using gypsum plaster, which exhibits quasi-brittle behavior similar to that of the mortar used in practice. The mechanical and geometrical similarities between the joint model and prototypes are evaluated through a series of loading tests. Additionally, lateral loading tests on SPSP models with 1 pipe, 1×2, and 2×1 arrangements are conducted under both 1 G and 50 G conditions. Based on the pipe-joint interaction (PJI) and the PJSI evaluated experimentally, it is found that the arrangement direction of the piles causes a significant variation in the load-displacement relationship. Specifically, in the 1×2 arrangement, the yielding of the pipes and the vertical shear failure of the joint occur compositely, resulting in a diverse variation in the load-displacement relationship. It is also observed that the subgrade reaction from the soil leads to the restoration of lateral bearing stiffness by causing the compressive failure of the joint in this arrangement. On the other hand, with the ground model, the compressive and vertical shear failure of the joint occur sequentially, dominating the lateral load curve of the 1×2 arrangement together with the subgrade reaction. Without the ground model, the lateral load-displacement curve of the 1×2 arrangement is mainly dominated by only the vertical shear failure of the joint.
What makes an epidemic a disaster: The future of epidemics within the EM-DAT International Disaster Database
Authors: Tonnelier Margo , Delforge Damien , Below Regina , Munguía Juan Armando Torres , Saegerman Claude , Wathelet Valentin , Loenhout Joris A.F. van , Speybroeck Niko 
Published: August 2024

Abstract

Background. Reporting on and monitoring epidemics is a public health priority. Several initiatives and platforms provide epidemiological data, such as the EM-DAT International Disaster Database, which has 1525 epidemics and their impact reported since 1900, including 892 epidemics between 2000 and 2023. However, EM-DAT has inconsistent coverage and deficiencies regarding the systematic monitoring of epidemics data due to the lack of a standardized methodology to define what will be included under an epidemic disaster.
Methods. We conducted a modified Delphi online survey among experts in infectious disease, public health emergencies, and related data to identify appropriate definitions and entry criteria for archiving disease outbreak events.
Results. The survey had 21 respondents from universities and international organizations, with experts primarily specialized in infectious disease surveillance. The majority (95%) agreed that epidemics should be considered as disasters. Experts cited challenges in defining epidemic thresholds. However, they proposed pathogen-based criteria and agreed that disruption to society, especially to the healthcare system, serves as a determinant of epidemic disasters. The experts favored deaths and confirmed cases as key indicators, alongside suggestions on refining EM-DAT's entry criteria and improving epidemic impact assessment.
Discussion. This article offers valuable insights into epidemic disasters, a topic previously underdefined in the literature, thereby enhancing understanding for policymakers and public health professionals.
Current challenges in detecting complex emotions from texts
Authors: Truong Vinh 
Published: August 2024

Abstract

Textual emotion detection is a critical area of study with significant applications in business, education, and healthcare. Despite substantial theoretical advancements over the years, there are notable gaps in the practical implementation of these methods in the aforementioned fields. The techniques currently available do not yet seem ready for real-world application. This study offers a comprehensive review of existing approaches, datasets, and models used in textual emotion detection. Its primary objective is to identify the challenges faced in both current literature and practical applications. The findings reveal that textual datasets annotated with emotional markers are scarce, making it difficult to develop robust supervised classification models for this task. There is also a pressing need for improved models that can accurately categorize a wider range of emotional states distinctly. Finally, there is a demand for techniques capable of dimensionally detecting valence, arousal, and dominance scores from emotional experiences. These challenges stem not only from the models and applications themselves but also from the readiness of current approaches and datasets in the rapidly evolving fields of machine learning and affective computing.
Six cases of portomesenteric vein thrombosis after 3511 patients of bariatric surgery without prophylactic anticoagulation
Authors: Meng Hua , Zhou Biao , Zhang Lei , Zhu Ming , Li Zhengqi , Qiao Qilu 
Published: August 2024

Abstract

Background: Portomesenteric vein thrombosis (PMVT) is a rare but potentially life-threatening complication following bariatric surgery (BS). Due to the limited number of reported cases, the clinical presentation, management, and outcomes of PMVT are not well understood.
Objective: This study aims to describe the incidence, clinical presentation, treatment, and outcomes of PMVT in patients who underwent BS at a single bariatric surgery center.
Methods: We conducted a retrospective review of a database of all patients who underwent BS and developed PMVT from July 2018 to April 2024 at one center.
Results: Out of 3511 patients who underwent BS, 2981 had laparoscopic sleeve gastrectomy (LSG) and 530 had laparoscopic Roux-en-Y gastric bypass (LRYGB). None of the patients received prophylactic anticoagulation post-surgery. Six patients (0.17%) who underwent LSG were diagnosed with PMVT. These patients had a mean age of 33.3 years and a mean preoperative body mass index (BMI) of 42.13 kg/m². The average time to diagnosis post-surgery was 11.5 days (range 10–36 days). All patients presented with epigastric pain. Treatment was exclusively medical, with no reoperations. Five patients were treated with enoxaparin, and all were treated with rivaroxaban for an average of four months (range 45–210 days). There were no fatalities.
Conclusion: Portal mesenteric vein thrombosis (PMVT) is a rare but serious complication following bariatric surgery, often presenting with nonspecific symptoms. High suspicion is essential for early diagnosis. At our center, the incidence of PMVT is relatively lower compared to previous studies that did not employ routine prophylactic anticoagulation. Further research is needed to determine whether routine prophylactic anticoagulation is necessary.
Nonlinear association between atherogenic index of plasma and chronic kidney disease: a nationwide cross-sectional study
Authors: jiang Chunqi , wang Bo , qu Yinuo , wang Jun , zhao Guang , zhang Xin 
Published: August 2024

Abstract

Background: Chronic kidney disease (CKD) is a kind of chronic disease which endangers human health seriously. The relationship between chronic kidney disease and atherogenic index of plasma (AIP) has rarely been explored. The present study investigates the association between AIP and CKD.
Methods: We utilized a weighted multivariate logistic regression model to rigorously assess the relationship between AIP and CKD, complemented by the generation of smooth curves to delineate the interplay between these variables. Upon discerning a non-linear relationship, we engaged a recursive partitioning algorithm in conjunction with a two-stage linear regression model to precisely determine the inflection point. Furthermore, stratified analyses were meticulously performed to dissect and elucidate the heterogeneity within population subgroups.
Results：The study involved 23888 participants from the United States. Within the regression model that accounted for all covariates, the odds ratio (OR) correlating CKD with AIP was calculated at 1.12 (95% CI: 0.91, 1.36), suggesting no significant association between AIP levels and the prevalence of CKD. However, the results of the linear trend test suggested that the relationship between them may be non-linear. Smooth curve analysis confirmed the non-linear relationship between AIP and CKD, and identified an inflection point at -0.55. Below this threshold, AIP exhibited a significant inverse correlation with CKD. In contrast, beyond the inflection point, a pronounced positive correlation was detected. Further stratified analyses elucidated distinct patterns: a non-linear association between AIP and CKD was observed in female participants and those aged 50 and above, whereas a linear association was noted among male participants and those below the age of 50. Subgroup analyses, focusing on the interplay of BMI, alcohol consumption, and smoking status, disclosed significant variations within these demographic subsets.
Conclusion：We found a curvilinear relationship between chronic kidney disease and atherogenic index of plasma.
Targeting SPINK5-FTH1 axis to overcome cisplatin resistance in head and neck carcinoma cells
Authors: Yao Hui , Zhang Caiyun , Zhu Guanghao , Li Haopu , Wang Jingjie , Zheng Hongliang , Zhu Minhui 
Published: August 2024

Abstract

Head and neck squamous cell carcinoma (HNSCC) are frequently treated with chemotherapeutic agents at first, but eventually develop resistance, which limits treatment success. Given its strong therapeutic efficacy, more research is required to identify the mechanism driving cisplatin resistance in HNSCCs. Data from 546 HNSCC patients were examined in the current research using the Cancer Genome Atlas (TCGA) database. Ferroptosis regulators' gene expression levels were employed in an unsupervised cluster analysis. Additionally, cox regression analysis and single-sample gene set enrichment analysis (ssGSEA) were performed. For determining the expression and function of SPINK5, reverse transcription polymerase chain reactions (qRT-PCR), western blots, colony formation assays, and transwell experiments were conducted in the HNSCC cell line. Mechanistically, our findings showed that SPINK5 is low in HNSCC and that malignant tissues with downregulated SPINK5 have a poor prognosis. High levels of SPINK5 causes down-regulation of FTH1, resulting in the activation of ferroptosis and sensitizing cisplatin resistant HNSCC cells to cisplatin. Finally, in HNSCC, SPINK5 might be a significant clinical indicator of ferroptosis and cisplatin resistance. Our study enlightens a novel molecular mechanism underlying SPINK5 induction and its role in ferroptosis and cisplatin chemotherapy resistance, thereby providing a possible novel mechanism of cisplatin resistance and offering experimental basis for clinical translation. Therefore, SPINK5 may play a crucial role in overcoming cisplatin resistance in the future and may act as a sensitive target for the development of cisplatin chemotherapy.
Comparison of the biological effects of various radiation therapy for keloid by single-cell RNA sequencing reveals IRF1 as a novel target in keloid therapy
Authors: Li Xiaoqian , Li Wei , Yan Tao , Guo Linfen , Feng Yahui , Liu Yulan , Ye Lu , Zhang Yuehua , Bai Hao , Chen Nianyong , Yu Daojiang , Zhang Shuyu 
Published: August 2024

Abstract

Background Keloids are benign dermal tumors that arise from abnormal wound healing processes following skin lesions. Postoperative radiotherapy (PORT) is a clinically effective measure to reduce recurrence rates of keloid with various radiation modalities. Nevertheless, studies comparing the effectiveness and underlying mechanisms of distinct radiotherapy modalities for keloid remain absent in the literature. Methods We performed single-cell RNA sequencing (scRNA-Seq) analysis of primary keloid fibroblasts treated with photon irradiation, electron beam irradiation or β-radiation using a90Sr-90Y surface applicator to explore gene expression profiles. Comparative analyses were also performed to identify the dysregulated pathways, regulators and ligand receptor interactions in five groups. To validate our findings, molecular biological approaches were used to confirm the potential target. Results Unbiased clustering revealed a considerable degree of cellular heterogeneity within primary keloid fibroblasts, resulting in the identification of seven distinct clusters. Among of them, the cell proportions of Fib2-CCND1high, Fib3-IGFBP7highand Fib 4-APCDD1highincreased significantly in X-rays group, electron beam group and both90Sr groups, which involved in microtubule associated complex, extracellular matrix organization and oxidative phosphorylation, respectively. In addition, the bioinformatics analysis highlighted the alteration of immune-associated interactions, such as PVR-TNFSF9 and TNFSF9-IL13RA2, and provided a basis for the activation of interferon regulatory factor 1 (IRF1) in all of radiotherapy modalities. Then, functional analysis revealed that Ad-IRF1 and pharmacological activation of IRF1 (ATRA and 9-cis-RA) significantly induced apoptosis and suppressed cell viability. Mechanistically, reciprocal regulation between the single-stranded DNA sensors SSBP1 and IRF1 was revealed. Conclusions This study illustrated the molecular alterations and driving transcription factors following various radiotherapy modalities at the single cell resolution. Notably, the identification of IRF1 as a prospective therapeutic target for keloid is of signification importance.
Mapping Sustainable Development Goals to Citizen Science projects - a comparative evaluation of automatic classifiers
Authors: Santos Patricia , Amarashinghe Ishari , Calvera-Isabal Miriam , Shulten Cleo , Hoppe Ulrich , Roldán-Álvarez David , Martínez-Martínez Fernando 
Published: August 2024

Abstract

Traditional data sources provide insufficient knowledge for measuring the United Nations Sustainable Development Goals (SDGs). Data related to SDGs are sourced primarily from global databases maintained by international organizations, national statistical offices and other government agencies. Recent studies show the value of using data from Citizen Science (CS) for assessing the SDGs. There is an important online presence of CS programs, professional networks for CS and online communities of citizen scientists, leading to the generation of several CS platforms. In this context, the role of computational data science is key. This paper explores and exemplifies opportunities for combining web-data mining techniques and automatic classifiers to enhance the understanding of the inter-relation between CS and the SDGs. An analysis of different automatic classifiers is presented by comparing the results obtained from their application in a sample of 208 CS project descriptions. The results of this study indicate the benefits and limitations of these techniques (nCoder, ESA, OSDG and BERT), but also provides a discussion of the potential benefits of using data from CS projects to map the 17 SDGs.
Surgical outcomes of laparoscopic versus open diverting colostomy for radiation-induced rectovaginal fistula
Authors: Liu Zhen , Ren Lu , Liu Enrui , Zhang Jinliang , Guo Dong 
Published: August 2024

Abstract

Background
Radiation-induced rectovaginal fistula (RI-RVF) is a distressful condition after radiotherapy for pelvic malignancies. Diverting colostomy is an effective procedure for improving the quality of life. The aim of this study was to compare the surgical outcomes of laparoscopic diverting colostomy with open surgery for RI-RVF.
Methods
66 patients developed RI-IVF after pelvic radiation for malignancies between January 2014 and December 2023 were retrospectively collected and analyzed, among which 28 patients received laparoscopic diverting colostomy and 38 patients undergone open surgery. A comparison of clinical features between the two groups was made initially. We also assessed the surgical and postoperative outcomes according to the approach used for diverting colostomy.
Results
The postoperative length of stay is significantly shorter in the laparoscopic group (6 ± 2.43 days) than in the open group (8 ± 3.33 days, p < 0.01). Laparoscopic surgery was associated with shorter length of incision (p < 0.01), lower pain score (p < 0.01), less days requiring analgesics (p < 0.01) and lower rate of surgical site infection (p = 0.04). There were no statistically significant differences between the two groups in terms of surgery time, blood loss, ICU admission, time to pass first flatus or defecation, to resume liquid or normal diet.
Conclusions
Laparoscopic diverting colostomy is feasible for patients with RI-RVF, albeit adhesions in the peritoneal cavity. Compared to open procedures, patients received laparoscopic surgery had a shorter length of hospital stay and lower incidence of surgical site infections. Previous surgical and radiation history is not a contraindication for laparoscopic colostomy, hence laparoscopic approach can be implemented safely in patients with RI-RVF.
Impact of Maternal SARS-CoV-2 Infection During Pregnancy on Offspring Neurodevelopment: Signature Cohort 12 Month Follow-Up.
Authors: Garrido-Torres Nathalia , Román-Jarrín Andrés , Rider Julia , Alemany-Navarro María , Gibson Blake A. , de-Felipe Bea , Pérez-Gómez Alberto , Cerrillos Lucas , Duque-Sánchez Cristina , Alameda Luis , Ruiz-Mateos Ezequiel , Ruiz-Veguilla Miguel , Crespo-Facorro Benedicto 
Published: August 2024

Abstract

The COVID-19 pandemic brought unprecedented global challenges. Amid the crisis, the potential impact of SARS-CoV-2 on the neurodevelopment of offspring born to infected mothers emerged as a critical concern. This is a prospective cohort study of offspring exposed to maternal SARS-CoV-2 mild or severe infection during pregnancy. Pregnant women who acquired SARS-CoV-2 were enrolled in the SIGNATURE project at Hospital Universitario Virgen del Rocio in Seville, Spain, between 01/01/2021 and 08/31/2022. Maternal stress was assessed through the Perceived Stress Scale; offspring neurodevelopment was assessed through Ages & Stages Questionnaire, 3rd Edition (ASQ-3) at 6 months and 12 months. Association between SARS-CoV-2 illness severity and neurodevelopmental outcomes were analyzed with univariate and multivariate analysis. The cohort included 671 women categorized into three distinct groups based on maternal SARS-CoV-2 severity: non-infected mothers (N = 272), mothers with mild symptoms (N = 346), and mothers with severe symptoms (N = 53). In utero exposure to maternal SARS-CoV-2 severe infection was associated with a significant delay in the ASQ-3 personal-social subdomain at 12 months follow-up [OR = 3.00 (95% CI 1.129–7.969), p = 0.028] independently of the timing of the infection and maternal stress. This study revealed a significant association between severe maternal SARS-CoV-2 infection during pregnancy and offspring neurodevelopmental delay at the 12-month follow-up, emphasizing the importance of understanding and addressing the potential long-term consequences of maternal SARS-CoV-2 infection on offspring neurodevelopment.
Slowly Oscillating Periodic Solutions of a Van der Pol Oscillator with State-Dependent Delay
Authors: Hou Aiyu , Liu shunlian , Luo Chaoliang 
Published: August 2024

Abstract

In this paper, we consider a Van der Pol oscillator with state-dependent delay. Firstly, we seek for a suitable set $E$ on which we construct a Poincar\'e operator $F$. Then, we prove that the operator $F$ is continuous and compact on $E\backslash\{0\}$. After that, we obtain the ejectivity of the trivial fixed point $\{0\}$ and the existence of slowly oscillating periodic solution. Finally, we choose an example of state-dependent delay to test our analytical result by comparing it to numerical continuation.This theoretical result generalizes and improves some existing results.
Oxidation behavior of MnCuNiFeZnAl damping alloy for high-temperature service
Authors: Mei Ling , Duan Pengbo , Guo Xiangcheng , Tian Qingchao 
Published: August 2024

Abstract

High-entropy Mn-based damping alloy is very promising for high-temperature service, and a MnCuNiFeZnAl damping alloy with the entropy of mixing of 9.39 Jmol− 1K− 1 was prepared to study the high-temperature oxidation behaviour. The in-situ XRD analysis indicates that oxidation begins at 673K with the formation of MnO, ZnO, and CuO, follows by the appearance of Mn3O4 and Mn2O3. It is found that the alloy shows improved antioxidation performance by forming continuous Al2O3 film in the substrate near the interface of the oxidation film / matrix, but also shows susceptibility to detachment of oxide scale under high temperatures. It is revealed that there exists the phenomenon of the split of MnO diffraction peaks during the growth process of oxide film, which is proposed to be originated from the MnO produced by either the redox reactions of Mn2O3 and Mn3O4 with Mn or the replacement reaction of MeO (Zn, Cu, Ni, Fe) with Mn.