bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased platelet reactivity in patients with late‐stage metastatic cancer
Authors: Cooke Niamh M. , Egan Karl , McFadden Siobhan , Grogan Liam , Breathnach Oscar S. , O'Leary John , Hennessy Bryan T. , Kenny Dermot 
Published: May 2013

AbstractPlatelet hyperreactivity is associated with an increased risk of thrombosis. Cancer patients are at an increased risk of thrombosis, a risk that increases with disease progression. While cancer patients show evidence of platelet activation in vivo, few studies have extensively assessed whether these patients display platelet hyperreactivity. We hypothesized that patients with metastatic cancer would display platelet hyperreactivity, reflecting their associated high risk of thrombosis. In a cohort of patients with metastatic cancer (n = 13), we assessed platelet function using well‐established assays of platelet reactivity (agonist‐induced platelet aggregation, spontaneous platelet aggregation, and agonist‐induced P‐selectin expression). In comparison with healthy controls (n = 10), patients with metastatic cancer displayed global platelet hyperreactivity. Agonist‐induced platelet aggregation responses to ADP (adenosine diphosphate), epinephrine, collagen, arachidonic acid, and PAR‐1 (protease‐activated receptor‐1) activating peptide, as well as spontaneous platelet aggregation, were significantly increased in patients with metastatic cancer. Furthermore, agonist‐induced platelet P‐selectin expression was also significantly increased within the patient cohort. We demonstrate that patients with metastatic cancer are characterized by global platelet hyperreactivity, a factor that may contribute to their increased risk of thrombosis.
Extra‐Large‐Pore Zeolites with UTL Topology: Control of the Catalytic Activity by Variation in the Nature of the Active Sites
Authors: Shamzhy Mariya V. , Shvets Oleksiy V. , Opanasenko Maksym V. , Kurfiřtová Lenka , Kubička David , Čejka Jiří 
Published: May 2013

AbstractThe catalytic behavior of isomorphously substituted B‐, Al‐, Ga‐, and Fe‐containing extra‐large‐pore UTL zeolites was investigated in the acylation of p‐xylene with benzoyl chloride and Beckmann rearrangement of 1‐indanone oxime. The clear synergism between the Brønsted acidity (i.e., the concentration and the strength of protonic acid sites) of UTL catalysts and their activity in benzoylation was established. (Ga)UTL zeolite containing the Brønsted acid sites of medium strength is characterized by the optimum activity and selectivity in the benzoylation of p‐xylene. Because of a higher accessibility of active centers, (Al)UTL zeolite appears to be a more active and selective catalyst than (Al)BEA in the benzoylation of p‐xylene. In contrast to (B), (Ga), and (Al)UTL, the leaching of active sites occurs in the benzoylation over (Fe)UTL. All UTL zeolites showed 100 % selectivity in the Beckmann rearrangement of 1‐indanone oxime, which provides the target 3,4‐dihydroquinolin‐2(1H)‐one. (B) and (Fe)UTL zeolites containing the weakest acid centers were found to be more active in the Beckmann rearrangement of 1‐indanone oxime than (Ga) and (Al)UTL: 100 % yield of the target amide was achieved in 240 min of the reaction time over (B) and (Fe)UTL.
Room Temperature Hydrogen Production from Ethanol over CeNiXHZOY Nano‐Oxyhydride Catalysts
Authors: Fang Wenhao , Pirez Cyril , Paul Sébastien , Capron Mickaël , Jobic Hervé , Dumeignil Franck , Jalowiecki‐Duhamel Louise 
Published: May 2013

AbstractCeNiXHZOY nano‐oxyhydride catalysts were developed for the highly efficient sustainable hydrogen production from ethanol and water in the oxidative steam reforming reaction. After an in situ treatment in hydrogen in the temperature range of 200–300 °C, the cerium–nickel binary mixed oxides became hydrogen reservoirs, which were called oxyhydrides, in the presence of hydrogen species of the hydride nature in the anionic vacancies of mixed oxides. A novel technology was developed for the room temperature hydrogen production by using the chemical energy released from the reaction between CeNiXHZOY nano‐oxyhydride catalysts and oxygen, which completely converted ethanol specifically at 60 °C (oven temperature) and simultaneously produced hydrogen, carbon dioxide, and carbon monoxide along with small amounts of methane and ethanal. CeNiXHZOY nano‐oxyhydride catalysts demonstrated excellent catalytic stability, which was attributed to the graphitic filamentous carbon formed during the reaction. The unique activation phenomenon of the reaction (a huge variation in the temperature between the catalyst bed and the oven) was demonstrated in detail. Finally, the correlations among the catalyst properties, the catalytic performances, and the characterizations were thoroughly discussed.
Base‐Free β‐Boration of α,β‐Unsaturated Imines Catalysed by Cu2O with Concurrent Enhancement of Asymmetric Induction
Authors: Calow Adam D. J. , Solé Cristina , Whiting Andrew , Fernández Elena 
Published: May 2013

AbstractThe stereoselective synthesis of γ‐aminoalcohols from the catalytic asymmetric β‐boration of α,β‐unsaturated imine precursors has been streamlined with the use of Cu2O as the catalyst, readily accessible (R)‐(+)‐2,2′‐bis(diphenylphosphino)‐1,1′‐binaphthyl as the chiral ligand and no additional base. The new simplicity of the catalytic system has the added value of in situ formation of the imines, which allows access to cyclic and acyclic β‐boryl imines. The reaction was followed by using in situ IR spectroscopy, which demonstrated the imine formation– β‐boration sequence and that the new catalytic system is superior to those employed for this reaction previously.
Enthalpy–Entropy Compensation Combined with Cohesive Free‐Energy Densities for Tuning the Melting Temperatures of Cyanobiphenyl Derivatives
Authors: Dutronc Thibault , Terazzi Emmanuel , Guénée Laure , Buchwalder Kerry‐Lee , Spoerri Aurore , Emery Daniel , Mareda Jiri , Floquet Sébastien , Piguet Claude 
Published: May 2013

AbstractThis work illustrates how minor structural perturbations produced by methylation of 4′‐(dodecyloxy)‐4‐cyanobiphenyl leads to enthalpy–entropy compensation for their melting processes, a trend which can be analyzed within the frame of a simple intermolecular cohesive model. The transformation of the melting thermodynamic parameters collected at variable temperatures into cohesive free‐energy densities expressed at a common reference temperature results in a novel linear correlation, from which melting temperatures can be simply predicted from molecular volumes.
Circular Dichroism Studies on Intermolecular Interactions of Amphotericin B in Ionic Liquid‐Rich Environments
Authors: Jameson Laramie P. , Dzyuba Sergei V. 
Published: May 2013

ABSTRACTAggregation of amphotericin B (AmB) in an ionic liquid‐rich environment was investigated using circular dichroism (CD) spectroscopy. It was found that nature of the ionic liquids’ anion had a strong impact not only on the aggregation of AmB, but more importantly on the nature of AmB aggregates, as observed in the asymmetry of the exciton couplet of the aggregate in CD spectra. Unique CD signals for AmB aggregates were observed in three different 1‐butyl‐3‐methylimidazolium ionic liquid solutions: [C4‐mim]Br favored the formation of AmB aggregates that were similar to those found in water, whereas [C4‐mim]BF4 and [C4‐mim]NO3 produced AmB aggregates that were different from each other and those found in water. The obtained results suggest that the designer solvent ability of ionic liquids could be expanded to address numerous intermolecular processes. Chirality 25:487‐492, 2013. © 2013 Wiley Periodicals, Inc.
Enantioselective Organocatalytic Aza‐Michael Additions of Phthalimide Derivatives to α,β‐Unsaturated Aldehydes
Authors: Ma Shijun , Liu Ming , Huang Yaodong , Wang Yongmei 
Published: May 2013

AbstractPhthalimide derivatives as nitrogen nucleophiles with α,β‐unsaturated aldehydes for asymmetric aza‐Michael additions have been reported. The reactions proceed smoothly to afford corresponding Michael adducts in good yields (up to 98%) and enantioselectivities (up to 95% ee).
Functionalized Bis(pentafluoroethyl)phosphanes: Improved Syntheses and Molecular Structures in the Gas Phase
Authors: Zakharov Alexander V. , Vishnevskiy Yury V. , Allefeld Nadine , Bader Julia , Kurscheid Boris , Steinhauer Simon , Hoge Berthold , Neumann Beate , Stammler Hans‐Georg , Berger Raphael J. F. , Mitzel Norbert W. 
Published: May 2013

Abstract(C2F5)2PNEt2 represents an excellent starting material for the selective synthesis of bis(pentafluoroethyl)phosphane derivatives. The moderately air‐sensitive aminophosphane is accessible on a multi‐gram scale by treating Cl2PNEt2 with C2F5Li. Treatment with gaseous HCl or HBr yielded the corresponding phosphane halides (C2F5)2PCl and the so far unknown (C2F5)2PBr in good yields. The hitherto unknown (C2F5)2PF was obtained by treating (C2F5)2PBr with excess antimony trifluoride. Treatment of (C2F5)2PCl with Bu3SnH led to the quantitative formation of (C2F5)2PH. Deprotonation formally yielded the (C2F5)2P– anion in a form that was stabilized by coordination to mercury ions to form the complex [Hg{P(C2F5)2}2(dppe)]. An improved high‐yielding synthesis of (C2F5)2POH was achieved by treating (C2F5)2PNEt2 with p‐toluenesulfonic acid. The gas‐phase structures of (C2F5)2PH and (C2F5)2POH were determined by electron diffraction. The vibrational corrections employed in the data analysis of the diffraction data were derived from molecular dynamics calculations. Both compounds exist in the gas phase mostly as C1‐symmetric cis,cis conformers with regard the orientation of the C2F5 groups relative to the functional groups H and OH. The presence of a second conformer at ambient temperature is likely in both cases. The refined amounts of dominant conformers are 94(6) and 85(6) % for (C2F5)2PH and (C2F5)2POH, respectively. The conformational behaviour was further explored by potential energy surface scans based on DFT calculations. Important experimental structural parameters for the most stable conformers are re(P–C)average = 1.884(3) Å for (C2F5)2PH and re(P–C)average = 1.894(4) Å and re(P–O) = 1.582(3) Å for (C2F5)2POH. The different coordination properties of (C2F5)3P, (C2F5)2POH, (CF3)3P and (CF3)2POH were evaluated by complex formation with [Ni(CO)4]: the maximum achievable number of CO ligands substituted by (C2F5)3P is 1, by (C2F5)2POH is 2, by (CF3)3P is 3 and by the smallest ligand (CF3)2POH is 4.
N‐Heterocyclic Carbenes Functioning as Monoligating Clamps
Authors: Teci Matthieu , Brenner Eric , Matt Dominique , Toupet Loïc 
Published: May 2013

AbstractInvited for the cover of this issue is the group of Dominique Matt at the University of Strasbourg. The cover image shows a palladium complex stabilized by an N‐heterocyclic carbene bearing two non‐rotating alkylfluorenyl substituents. The NHC ligand functions like a clamp to permanently protect two trans‐located coordination sites.
Synthetic Access to Hydrogen and Halogen Derivatives of 3‐Amino‐4‐nitrothiophenes
Authors: Vogt Eva‐Janina , Zapol'skii Viktor A. , Nutz Eva , Kaufmann Dieter E. 
Published: May 2013

AbstractThe unique synthesis of 3‐amino‐4‐nitrothiophenes 2 provides easy access to reference species of a new family of push‐pull substituted thiophenes. The chemoselective modification of 2 into suitable derivatives was accomplished by selective S‐oxidation of the vinylsulfanyl unit, followed by substitution of the vinylsulfinyl group of 3 by nucleophiles. Dihalothiophenes were formed this way in very good yields. A subsequent selective dehalogenation at the 2, 5 or 2 and 5 positions also proved feasible, and the push‐pull unit was untouched. The new 2,5‐dihalothiophenes could be interesting monomers for conducting polymers.
Practical evaluation of organic polymer thermoelectrics by large‐area R2R processing on flexible substrates
Authors: Søndergaard Roar R. , Hösel Markus , Espinosa Nieves , Jørgensen Mikkel , Krebs Frederik C. 
Published: May 2013

AbstractHere, we present a process based on roll‐to‐roll (R2R) technology which allows for very fast processing of polymer thermoelectric (TE) devices and we furthermore demonstrate a simplified but more efficient way of serially connecting these devices by means of R2R thin‐film processing. The new device architecture makes it possible to use only one TE material (opposed to two materials which are employed in well‐known Peltier elements), and a total of 18,000 serially connected junctions were prepared by flexoprinting of silver electrodes and by rotary screen printing of poly(3,4‐ethylenedioxythiophene) (PEDOT):polystyrene sulfonate (PSS) as the TE material. Testing of devices revealed that the new architecture clearly showed to be functioning as expected, but also pointed toward challenges for thin‐film TE development which is the influence of the substrate thickness on the thermal gradient over a device and the currently low performance available. A life‐cycle assessment (LCA) was carried out in order to evaluate the sustainability of the new architecture and to estimate the requirements for development of a successful technology.
Some mechanisms of FLIP expression in inhibition of HIV‐1 replication in Jurkat cells, CD4+ T cells and PBMCs
Authors: Tan Jiying , Wang Xue , Devadas Krishnakumar , Zhao Jiangqin , Zhang Panhe , Hewlett Indira 
Published: May 2013

AbstractHIV‐1 infection and replication are affected by host factors. Recent studies demonstrate that molecules from apoptotic pathways regulate HIV‐1 replication. Therefore, studies on effects of host factors that maintain host cell survival and influence HIV‐1 replication are critical to understanding the mechanisms of HIV‐1 replicative cycle. Using the susceptible Jurkat cell line, CD4+ T cells, and peripheral blood mononuclear cells (PBMCs), we studied the role of FLIP, an inhibitor of caspase‐8, in HIV‐1 production. Full length cellular FLIP (cFLIP) inhibited HIV‐1 replication in these cells. cFLIP upregulated the expression of viral restriction factors, such as TRIM5, Apobec3G, and Bst2/tetherin, decreased nuclear factor 1C expression and inactivated ERK and p38 induced by HIV‐1 in Jurkat cells. cFLIP blocked the trafficking of gp120 and Gag p24 capsid protein into lipid rafts with inhibition of Tsg101 and Alix in ESCRT signaling pathway. cFLIP also promoted Bst2/tetherin trafficking into lipid rafts. These results indicate that cFLIP may inhibit the HIV‐1 replication cycle at multiple steps, including viral RNA release, transcription, traffic and assembly. We also found that cFLIP expression downregulated Fas expression and inactivated FADD in the Fas‐mediated apoptotic pathway. The inactivated FADD also inhibited HIV‐1 replication. J. Cell. Physiol. 228: 2305–2313, 2013. © 2013 Wiley Periodicals, Inc.
Expression of microRNA‐184 in keratinocytes represses argonaute 2
Authors: Roberts Julian C. , Warren Richard B. , Griffiths Christopher E.M. , Ross Kehinde 
Published: May 2013

ABSTRACTInterleukin‐22 (IL‐22) is a proinflammatory cytokine that has been associated with the pathogenesis of inflammatory skin disorders. However, the impact of IL‐22 on microRNA (miRNA) expression in epidermal keratinocytes is unknown. Here we show that IL‐22 induces miR‐184 in reconstituted human epidermis (RHE) and in the HaCaT keratinocyte cell line. Exposure to IL‐22 increased miR‐184 expression 8‐ and 15‐fold in RHE and HaCaT cells, respectively. Oncostatin M, an unrelated proinflammatory cytokine, also raised miR‐184 expression in RHE and HaCaT keratinocytes. Pharmacologic and genetic inhibition demonstrated that cytokine‐induced expression of miR‐184 was mediated by signal transducer and activation of transcription 3 (STAT3). Argonaute 2 (AGO2), a member of the RNA‐induced silencing complex (RISC), is a predicted miR‐184 target. Using protein, messenger RNA and reporter analyses, we found that miR‐184 regulates the expression of AGO2. We conclude that cytokine‐induced miR‐184 attenuates AGO2 expression in keratinocytes. J. Cell. Physiol. 228: 2314–2323, 2013. © 2013 Wiley Periodicals, Inc.
miR‐10a restores human mesenchymal stem cell differentiation by repressing KLF4
Authors: Li Jiao , Dong Jun , Zhang Zhen‐hui , Zhang Dong‐Cheng , You Xiang‐Yu , Zhong Yun , Chen Min‐Sheng , Liu Shi‐Ming 
Published: May 2013

AbstractmiRNAs have recently been shown to play a significant role in human aging. However, data demonstrating the effects of aging‐related miRNAs in human mesenchymal stem cells (hMSCs) are limited. We observed that hMSC differentiation decreased with aging. We also identified that miR‐10a expression was significantly decreased with age by comparing the miRNA expression of hMSCs derived from young and aged individuals. Therefore, we hypothesized that the downregulation of miR‐10a may be associated with the decreased differentiation capability of hMSCs from aged individuals. Lentiviral constructs were used to up‐ or downregulate miR‐10a in young and old hMSCs. Upregulation of miR‐10a resulted in increased differentiation to adipogenic, osteogenic, and chondrogenic lineages and in reduced cell senescence. Conversely, downregulation of miR‐10a resulted in decreased cell differentiation and increased cell senescence. A chimeric luciferase reporter system was generated, tagged with the full‐length 3′‐UTR region of KLF4 harboring the seed‐matched sequence with or without four nucleotide mutations. These constructs were cotransfected with the miR‐10a mimic into cells. The luciferase activity was significantly repressed by the miR‐10a mimic, proving the direct binding of miR‐10a to the 3′‐UTR of KLF4. Direct suppression of KLF4 in aged hMSCs increased cell differentiation and decreased cell senescence. In conclusion, miR‐10a restores the differentiation capability of aged hMSCs through repression of KLF4. Aging‐related miRNAs may have broad applications in the restoration of cell dysfunction caused by aging. J. Cell. Physiol. 228: 2324–2336, 2013. © The Authors. Published by Wiley Periodicals, Inc.
Utilization of ammonia‐containing wastewater by combining membrane absorption and vacuum membrane distillation
Authors: Lu Jun , Li Baoan , Wang Li , Wang Yue , Wang Shichang 
Published: May 2013

AbstractBackgroundIn this study, membrane absorption and vacuum membrane distillation were integrated to recover ammonia and water, respectively, from saline ammonia‐containing wastewater discharged by metallurgical plants.ResultsAmmonia was removed by membrane absorption with a parallel hollow fiber membrane (HFM) module to decrease the ammonia content to below 5 mg L−1. Then the wastewater was concentrated by vacuum membrane distillation with a cross‐flow HFM module to maximize fresh water recovery, while maintaining higher permeate flux levels. The Taguchi method was used for experiment designs and contributions of operating parameters were determined over the specified parameter ranges through variance analysis. Recovery of ammonia and fresh water reached 99.8% and 80% within 250 min and 160 min, respectively. Membrane fouling in the membrane distillation process could be mitigated at lower concentrate rate in semi‐batch running mode, while permeate flux was maintained at high levels for a longer time. Permeate flux was greatly restored through a cleaning technique consisting of alkaline cleaning, acid picking, EDTA washing and drying. Permeate flux loss due to irreversible membrane fouling was 0.7%.ConclusionThe experimental results demonstrate the potential for resource utilization of saline ammonia‐containing wastewater by combining membrane absorption and vacuum membrane distillation. © 2013 Society of Chemical Industry
Updated high‐resolution grids of monthly climatic observations – the CRU TS3.10 Dataset
Authors: Harris I. , Jones P.D. , Osborn T.J. , Lister D.H. 
Published: May 2013

ABSTRACTThis paper describes the construction of an updated gridded climate dataset (referred to as CRU TS3.10) from monthly observations at meteorological stations across the world's land areas. Station anomalies (from 1961 to 1990 means) were interpolated into 0.5° latitude/longitude grid cells covering the global land surface (excluding Antarctica), and combined with an existing climatology to obtain absolute monthly values. The dataset includes six mostly independent climate variables (mean temperature, diurnal temperature range, precipitation, wet‐day frequency, vapour pressure and cloud cover). Maximum and minimum temperatures have been arithmetically derived from these. Secondary variables (frost day frequency and potential evapotranspiration) have been estimated from the six primary variables using well‐known formulae. Time series for hemispheric averages and 20 large sub‐continental scale regions were calculated (for mean, maximum and minimum temperature and precipitation totals) and compared to a number of similar gridded products. The new dataset compares very favourably, with the major deviations mostly in regions and/or time periods with sparser observational data. CRU TS3.10 includes diagnostics associated with each interpolated value that indicates the number of stations used in the interpolation, allowing determination of the reliability of values in an objective way. This gridded product will be publicly available, including the input station series (http://www.cru.uea.ac.uk/ and http://badc.nerc.ac.uk/data/cru/). © 2013 Royal Meteorological Society
Assessment of economic and environmental impacts of two typical cotton genotypes with contrasting potassium efficiency
Authors: Yanshu Hao , Xiaoli Wang , Ying Xia , Lishu Wu , Cuncang Jiang 
Published: May 2013

AbstractIt is essential to produce optimal crop yields while reducing adverse environmental impacts of overfertilization. Therefore, nutrient‐efficient plants may play a major role in improving the efficiency of fertilizer use whilst increasing crop yields. This field trial was conducted to study the differences on absorption and utilization of nitrogen (N), phosphorus (P), and potassium (K) of K‐efficient cotton genotype 103 and K‐inefficient cotton (Gossypium hirsutum L.) genotype 122 and their environmental and economic effects. The results show that seed cotton yield was significantly different between K‐efficient cotton genotype 103 and K‐inefficient cotton genotype 122; the yields of genotype 103 were 39.2%, 33.8%, and 25.0% higher than those of genotype 122 with no K fertilizer (K0), 112 kg K ha–1 K (K1), and 224 kg K ha–1 (K2), respectively. Even when no K fertilizer was applied, the yield of genotype 103 was still 7.9% higher than the yield of genotype 122 at the highest K level (K2). Further economic benefit analysis revealed that the value cost ratio (VCR) of genotype 103 was significantly higher than 122 at K0 and K1, and harvest index (HI) of genotype 103 was significantly higher than that of genotype 122 at all three K levels. In addition, when fertilized with K, partial factor productivity of applied K (PFPK) of genotype 103 was dramatically higher than that of genotype 122, demonstrating that genotype 103 had stronger ability to utilize K. Besides, the N‐ and P‐use efficiencies of genotype 103 were also higher than those of genotype 122. It is concluded that: (1) genotype 103 gives better profit than genotype 122 and (2) genotype 103 uses fertilizer more efficiently and reduced fertilizer inputs will alleviate environmental risks.