bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study of the Surgically Relevant Mechanical Characteristics of the Topical Skin Adhesives
Authors: Singer Adam J. , Perry Larry 
Published: November 2012

AbstractObjectivesTopical skin adhesives (TSAs) offer a noninvasive alternative to sutures. The growing trend is to use them in addition to sutures and staples to add strength and provide a microbial barrier. The authors compared the mechanical characteristics of recently approved TSAs that are most likely to be of surgical relevance in the emergency department.MethodsLinear incisions were made on anesthetized swine and the wounds were approximated with one of six commercially available TSAs. Three‐dimensional bursting strength was measured with a BTC‐2000TM device. Tensile failure force was measured ex vivo using TSA‐approximated porcine skin strips with a tensionometer. Resistance to cyclic loading was measured by subjecting approximated skin strips to repetitive cycles of rotational torque and linear tension. Viscosity was measured with a viscometer and setting times were measured by periodically dabbing the adhesive applied to skin strips with a cotton swab to determine whether it was dry.ResultsDermabond Advanced TSA provided significantly (p < 0.00001) greater acute in vivo wound bursting strength and ex vivo tensile force, greater mean number of normal tensile loading cycles to failure (while under continuous torsional cycling), and longest time to failure, and the mean setting time was the shortest.ConclusionsOf all the TSAs tested in this study, Dermabond Advanced was the strongest and most flexible, set in the shortest time, and was a fairly viscous adhesive, all of which are clinically desirable characteristics.
A Model for Emergency Department End‐of‐life Communications After Acute Devastating Events—Part II: Moving From Resuscitative to End‐of‐life or Palliative Treatment
Authors: Limehouse Walter E. , Ramana Feeser V. , Bookman Kelly J. , Derse Arthur 
Published: November 2012

AbstractThe model for emergency department (ED) end‐of‐life communications after acute devastating events addresses decision‐making capacity, surrogates, and advance directives, including legal definitions and application of these steps. Part II concerns communications moving from resuscitative to palliative and end‐of‐life treatments. After completing the steps involved in determining decision‐making, emergency physicians (EPs) should consider starting palliative measures versus continuing resuscitative treatment. As communications related to these end‐of‐life decisions increasingly fall within the scope of emergency medicine (EM) practice, we need to become educated about and comfortable with them.
Risk of postpartum uterine synechiae following uterine compression suturing during postpartum haemorrhage
Authors: Ibrahim Moustafa I. , Raafat Tarek A. , Ellaithy Mohamed I. , Aly Rehab T. 
Published: November 2012

BackgroundUterine compression suturing is considered a successful, safe, inexpensive and simple ‎method for the conservative treatment of atonic postpartum haemorrhage (PPH). However, insufficient data are available about the potential risk of subsequent intrauterine ‎synechiae (IUS).AimTo determine the risk of postpartum uterine synechiae in women who received isolated uterine compression suturing for the management of major uncontrolled PPH.Materials & MethodsAll women with major PPH from May 2005 to June 2011 were reviewed retrospectively. Diagnostic hysteroscopy was performed to assess the uterine cavity in the 27 women who successfully underwent isolated uterine compression suturing for major atonic PPH and fulfilled the study inclusion and exclusion criteria.ResultsAmong the 27 women who underwent isolated uterine compression suturing, 5 (18.5%) were found to have IUS on hysteroscopic examination. The mode of delivery for all women who developed IUS was caesarean section. Among these five women, three had mild IUS, one had moderate IUS and one had severe IUS. All adhesions were later successfully resected by hysteroscopy, except for one case with dense IUS.ConclusionsUterine compression suturing was found to be associated with a risk of postpartum uterine synechiae formation, which may subsequently affect future fertility.
The effect of pre‐procedure anxiety on sedative requirements for sedation during colonoscopy
Authors: Chung K.‐C. , Juang S.‐E. , Lee K.‐C. , Hu W.‐H. , Lu C.‐C. , Lu H.‐F. , Hung K.‐C. 
Published: November 2012

SummaryThis study investigated the effects of pre‐procedural anxiety (assessed using the Beck Anxiety Inventory) on sedative requirements in 135 patients undergoing sedation for colonoscopy. Deep sedation was defined as loss of consciousness and no response to colonoscopy, and was achieved by target‐controlled infusion of propofol. Patients' characteristics, baseline haemodynamic profiles, Beck Anxiety Inventory scores, effect‐site propofol concentration at loss of consciousness and characteristics of recovery were recorded. No correlations were found between Beck Anxiety Inventory scores and effect‐site propofol concentration at loss of consciousness or baseline haemodynamic profiles. There was no statistical difference in the characteristics of recovery among patients with different levels of anxiety. In conclusion, in patients receiving deep sedation for colonoscopies, the level of pre‐procedural anxiety did not relate to the sedative requirement or post‐procedural recovery characteristics.
Effects of melatonin on salsolinol‐induced prolactin secretion in goats
Authors: Hashizume Tsutomu , Yaegashi Tomoyoshi , Jin Jin , Sawai Ken , Fülöp Ferenc , Nagy György Miklos 
Published: November 2012

AbstractThe aim of the present study was to clarify the effect of melatonin (MEL) on the salsolinol (SAL)‐induced release of prolactin (PRL) in goats. Female goats were kept at 20°C with 16 h of light, 8 h of darkness, and orally administered saline or MEL for 5 weeks. A single intravenous (i.v.) injection of saline (controls), SAL, thyrotropin‐releasing hormone (TRH) or a dopamine receptor antagonist, sulpiride, was given to the goats 3 weeks after the first oral administrations of saline or MEL, and the responses were compared. The mean basal plasma PRL concentrations in the control group were higher for the saline treatments than MEL treatments (P < 0.05). SAL as well as TRH and sulpiride stimulated the release of PRL promptly after each injection in both the saline‐ and MEL‐treated groups (P < 0.05). The area under the response curve of PRL for the 60‐min period after the i.v. injection of SAL, TRH and sulpiride in the saline‐treated group was greater than each corresponding value in the MEL‐treated group (P < 0.05). These results show that daily exposure to MEL under a long day length reduces the PRL‐releasing response to SAL as well as TRH and sulpiride in goats.
Basilar artery stroke in childhood
Authors: GOEGGEL SIMONETTI BARBARA , RITTER BARBARA , GAUTSCHI MATTHIAS , WEHRLI EDITH , BOLTSHAUSER EUGEN , SCHMITT‐MECHELKE THOMAS , WEBER PETER , WEISSERT MARKUS , EL‐KOUSSY MARWAN , STEINLIN MAJA 
Published: November 2012

Aim  Little is known about basilar artery stroke (BAS) in children. The objective of this study was to calculate the incidence of BAS in children and to analyse the clinical presentation, risk factors, radiological findings, therapeutic approaches, and outcome of BAS in childhood.Method  A prospective, population‐based study including children with arterial ischaemic stroke and a systematic review of the literature was undertaken.Results  Seven children with BAS were registered at the Swiss Neuropaediatric Stroke Registry between January 2000 and June 2011 (incidence 0.037 per 100 000 children per year, 95% confidence interval [CI] 0.013–0.080). A further 90 cases were identified through the literature search. The majority of patients were male (73 males, 24 females) and the median age was 9 years (interquartile range [IQR]=6–13y). The median Pediatric National Institutes of Health Stroke Scale (PedNIHSS) score was 15 (IQR=4–27). Presenting signs and symptoms comprised impaired consciousness (n=64), quadri‐ or hemiparesis (n=58), bulbar dysfunction (n=46), vomiting, nausea (n=43), and headache (n=41). Prodromes occurred in 43% of cases. Aetiology was largely vasculopathic (n=38), but often unknown (n=40). Time to diagnosis varied from hours days; six patients received antithrombotic, thrombolytic, or mechanical endovascular treatment 12 hours or less after symptom onset. Outcome was good (modified Rankin Scale 0–2) in 45 patients; eight died. PedNIHSS score of up to 17 was a prognostic factor for good outcome.Interpretation  BAS is rare in children. Compared with adults, outcome is more favourable despite a considerable delay in diagnosis and treatment. Outcome was better in children with a PedNIHSS score of 17 or less.
Pulp polyp in traumatized primary teeth – a case–control study
Authors: Jabbar Nadia Salem Abdel , Aldrigui Janaina Merli , Braga Mariana Minatel , Wanderley Marcia Turolla 
Published: November 2012

AbstractAimTo assess clinical characteristics and other factors associated with the occurrence of pulp polyp in traumatized primary teeth as well to evaluate the impact of pulp polyp occurrence on clinical decision‐making after traumatic injuries.Material and methodsThis study was divided into three phases. First, occurrence and clinical characteristics of pulp polyp were assessed followed by a descriptive analysis and categorical tests of association. Secondly, a case–control design was used, and the occurrence of pulp polyp was set as the outcome. In third phase, the occurrence of pulp polyp after fracture with pulp exposure was investigated as a variable possibly associated with clinical decision‐making (dental extraction/endodontic treatment). Logistic regression analyses were used, and odds ratios and 95% confidence interval (OR; 95% CI) were calculated in second and third phases.ResultsOccurrence of pulp polyp in traumatized primary teeth was of 2.3%. Hyperplastic tissue color and proliferation size were not associated with the time to seek treatment after injury (P > 0.05). Children up to 2 years of age had more chance of having pulp polyp in comparison with older children (3.15; 1.15–8.64). Teeth with crown–root fracture had more chance of dental extraction in the therapeutic approach than the teeth with only crown fracture (4.36; 1.10–17.32). Presence of pulp polyp was not associated with the treatment carried out.ConclusionsOccurrence of pulp polyp in traumatized primary teeth is not frequent and is associated with the age when traumatic dental injury occurs but does not interfere directly with the therapeutic approach.
Can cognitive deficits facilitate differential diagnosis between at‐risk mental state for psychosis and depressive disorders?
Authors: Schulze Carla , Zimmermann Ronan , Gschwandtner Ute , Pflueger Marlon O. , Rapp Charlotte , Studerus Erich , Riecher‐Rössler Anita 
Published: November 2012

AbstractAimMany studies have provided evidence of cognitive deficits in individuals in an ‘At Risk Mental State’ (ARMS) for psychosis, which makes neuropsychology potentially useful in the early detection of psychosis. As depression is an important differential diagnosis in prodromal states of psychosis, the specificity of neurocognitive deficits inARMSindividuals as compared with non‐psychotic depressive disorders is investigated.MethodsNeurocognitive performance of four groups was analysed: 22ARMSindividuals with later transition to psychosis (ARMS‐T), 25ARMSindividuals without later transition to psychosis (ARMS‐NT), 34 controls with depressive disorders and 76 healthy controls. The subjects were assessed with a neurocognitive test battery covering the domains’ intelligence, executive function and attention/ working memory.MANOVAs,ANOVAs and Tukey's tests were applied after adjustment for confounding factors.ResultsARMS‐T showed significant cognitive deficits in working memory and in certain executive function tasks compared with healthy controls as well as with controls with depression. Controls with depression were only impaired in time per move in the tower of Hanoi test when compared with healthy controls.ConclusionsThe psychosis prodrome seems to be associated with cognitive deficits in the domains of working memory and executive function. In contrast, depressive patients showed no cognitive deficits, but slowing in one executive function task. Neurocognitive testing might therefore contribute to the differential diagnosis between prodromal psychosis and depressive disorders.
Differentiated information on antidepressants at hospital discharge: a hypothesis-generating study
Authors: Desplenter Franciska , Laekeman Gert ,   the GIPPOZ Research Group, Simoens Steven 
Published: November 2012

Abstract

Objectives
This hypothesis-generating study examined the clinical, humanistic and economic impact of providing differentiated medication information depending on the patient's information desire as compared with undifferentiated information to patients with a major depressive episode at hospital discharge.

Methods
A longitudinal multi-centre study with quasi-experimental design comprised two experimental groups ((un)differentiated antidepressant information) and one ‘no information’ group. Patients were followed up for 1 year assessing adherence, economic outcomes (i.e. costs of medicines, consultations, productivity loss and re-admissions), clinical outcomes (i.e. depressive, anxiety and somatic symptoms and side effects) and humanistic outcomes (i.e. quality of life, satisfaction with information). A linear model for repeated measures was applied to assess differences over time and between groups.

Key findings
Ninety-nine patients participated. Still participating 1 year later were 78. No beneficial effect was observed for adherence. Lower productivity loss (P = 0.021) and costs of consultations with healthcare professionals (P = 0.036) were observed in the differentiated group. About one-third of patients were re-admitted within 1 year following discharge. Patients in the ‘no information’ group had significantly more re-admissions than patients in the undifferentiated group (P = 0.031).

Conclusions
The hypothesis of differentiated information could be supported for economic outcomes only. Future medication therapy intervention studies should apply a more rigorous study design.
Effect of number and location of distant metastases on renal cell carcinoma mortality in candidates for cytoreductive nephrectomy: Implications for multimodal therapy
Authors: Capitanio Umberto , Abdollah Firas , Matloob Rayan , Salonia Andrea , Suardi Nazareno , Briganti Alberto , Carenzi Cristina , Rigatti Patrizio , Montorsi Francesco , Bertini Roberto 
Published: November 2012

ObjectiveTo test whether the combination of number and location of distant metastases affects cancer‐specific survival in patients with metastatic renal cell carcinoma.MethodsOverall, 242 metastatic renal cell carcinoma patients with synchronous metastases at diagnosis underwent cytoreductive nephrectomy at a single institution. Combinations of number and location of distant metastases were coded as: single metastasis and single organ affected, multiple metastases and single organ affected, single metastasis for each of the multiple organs affected, and multiple metastases for each of the multiple organs affected. Covariates included age, symptoms, performance status, American Society of Anesthesiologists score, hemoglobin, lactate dehydrogenase, tumor size, Fuhrman grade, T stage, lymph node status, necrosis, sarcomatoid features and metastasectomy at the time of nephrectomy.ResultsThe median survival was 34.7 versus 32.3 versus 29.6 versus 8.5 months for single metastasis and single organ affected, multiple metastases and single organ affected single metastasis for each of the multiple organs affected, and multiple metastases for each of the multiple organs affected patients, respectively. At multivariable analyses, the combination of number and location of distant metastases resulted in one of the most informative and independent predictors of cancer‐specific survival in metastatic renal cell carcinoma patients. The lung was the location with the highest rate of single organ affected (50.3% vs 35.1% in other sites; P < 0.001). Considering only patients with a single metastasis, no statistically significantly different cancer‐specific survival rates were recorded (P > 0.3) among different metastatic organs.ConclusionsAmong metastatic renal cell carcinoma patients undergoing cytoreductive nephrectomy, the combination of the number and location of distant metastases is a major independent predictor of cancer‐specific survival. Patients with multiple organs affected by multifocal disease are more likely to have poorer survival.
A pilot study evaluating non‐contact low‐frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers
Authors: Yao Min , Hasturk Hatice , Kantarci Alpdogan , Gu Guosheng , Garcia‐Lavin Silvia , Fabbi Matteo , Park Nanjin , Hayashi Hisae , Attala Khaled , French Michael A , Driver Vickie R 
Published: November 2012

AbstractNon‐contact low‐frequency ultrasound (NCLF‐US) devices have been increasingly used for the treatment of chronic non‐healing wounds. The appropriate dose for NCLF‐US is still in debate. The aims of this pilot study were to evaluate the relationship between dose and duration of treatment for subjects with non‐healing diabetic foot ulcers (DFUs) and to explore the correlation between wound healing and change of cytokine/proteinase/growth factor profile. This was a prospective randomised clinical study designed to evaluate subjects with non‐healing DFUs for 5 weeks receiving standard of care and/or NCLF‐US treatment. Subjects were randomly assigned to one of the three groups: application of NCLF‐US thrice per week (Group 1), NCLF‐US once per week (Group 2) and the control (Group 3) that received no NCLF‐US. All subjects received standard wound care plus offloading for a total of 4 weeks. Percent area reduction (PAR) of each wound compared with baseline was evaluated weekly. Profiles of cytokines/proteinase/growth factors in wound fluid and biopsied tissue were quantified to explore the correlation between wound healing and cytokines/growth factor expression. Twelve DFU patients, 2 (16·7%) type 1 and 10 (83·3%) type 2 diabetics, with an average age of 58 ± 10 years and a total of 12 foot ulcers were enrolled. Average ulcer duration was 36·44 ± 24·78 weeks and the average ABI was 0·91 ± 0·06. Group 1 showed significant wound area reduction at weeks 3, 4 and 5 compared with baseline, with the greatest PAR, 86% (P < 0·05); Groups 2 and 3 showed 25% PAR and 39% PAR, respectively, but there were no statistically significant differences between Groups 2 and 3 over time. Biochemical and histological analyses indicated a trend towards reduction of pro‐inflammatory cytokines (IL‐6, IL‐8, IL‐1β, TNF‐α and GM‐CSF), matrix metalloproteinase‐9 (MMP‐9), vascular endothelial growth factor (VEGF) and macrophages in response to NCLF‐US consistent with wound reduction, when compared with control group subjects. This proof‐of‐concept pilot study demonstrates that NCLF‐US is effective in treating neuropathic diabetic foot ulcers through, at least in part, inhibiting pro‐inflammatory cytokines in chronic wound and improving tissue regeneration. Therapeutic application of NFLU, thrice (3) per week, renders the best wound area reduction.
Complete remission of recurrent ovarian clear cell carcinoma by chemotherapy with bevacizumab, trabectedin and oxaliplatin
Authors: Takano Masashi , Ikeda Yuji , Kudoh Kazuya , Kita Tsunekazu , Sasaki Naoki , Kikuchi Yoshihiro 
Published: November 2012

AbstractClear cell carcinoma of the ovary has shown an exceedingly chemo‐resistant phenotype, especially in cases that are recurrent or refractory to previous therapy. Also, progression‐free survival was less than 6 months, even in the patients that achieved response when they were treated with conventional anti‐cancer cytotoxic agents. We present a case with recurrent and refractory ovarian clear cell carcinoma that achieved complete remission using a combination of bevacizumab, trabectedin and oxaliplatin. The progression‐free interval of the patient is over 30 months, and she is still receiving the combination therapy without toxicities of more than grade 2.
More Selective Removal of Myeloperoxidase‐Anti‐Neutrophil Cytoplasmic Antibody From the Circulation of Patients With Vasculitides Using a Novel Double‐Filtration Plasmapheresis Therapy
Authors: Gong Dehua , Ji Daxi , Xu Bin , Liu Zhihong 
Published: November 2012

AbstractOur aim was to investigate the removal of myeloperoxidase‐anti‐neutrophil cytoplasmic antibody (MPO‐ANCA) from the circulation of patients with vasculitides by double‐filtration plasmapheresis (DFPP) using various primary separator and secondary separator combinations. Nineteen patients diagnosed with vasculitides positive for serum MPO‐ANCA were enrolled and received 56 sessions of DFPP. One patient received three sessions of DFPP using MPS07 (the primary filter)/EC50W (the secondary filter), nine patients received 27 sessions of DFPP using MPS07/EC20W, and the other nine patients received 26 sessions of DFPP using EC50W/EC20W. The sieving coefficients (SC) of albumin, immunoglobulin (Ig)A, IgG and IgM were measured, as well as the reduction ratio in plasma protein concentrations and MPO‐ANCA titer after a single session of DFPP. The MPS07 filter was well permeable for all the above‐mentioned plasma proteins; the EC50W and EC20W filters were permeable for albumin and IgG, less for IgA and IgM. During DFPP using MPS07/EC50W, the reduction ratio of IgG was much lower than IgM and IgA (30.5 ± 9.0% vs. 89.7 ± 5.4% and 61.7 ± 14.8%). During DFPP using MPS07/EC20W, the decline in IgM, IgA, and IgG was 94.2 ± 3.1%, 96.2 ± 2.3%, and 64.7 ± 21.0%, respectively. During DFPP using EC50W/EC20W, the decline in IgM, IgA, and IgG was 2.8 ± 12.9%, 90.9 ± 4.4%, and 43.5 ± 13.8%, respectively. The percentage reduction in MPO‐ANCA titer after a single session of DFPP using EC50W/EC20W was 34.6 ± 14.3%. DFPP using EC50W/EC20W filters may be more selective for the removal of pathogens such as IgG, with subsequently effective reduction of serum ANCA titer.
Very low‐energy diets for weight loss in adults: A review
Authors: Asher Roberta C.Z. , Burrows Tracy L. , Collins Clare E. 
Published: November 2012

AbstractAim:  Very low‐energy diets are a weight loss strategy that utilises severe and controlled energy restriction to induce rapid weight loss. This review aimed to evaluate their use in terms of efficacy and safety, and to identify for whom they may be effective for weight loss.Methods:  English‐language papers examining the use of very low‐energy diets for weight loss in adults with a body mass index ≥30 kg/m2 and published between March 2003 and March 2010 were retrieved from health and medical databases.Results:  Eight randomised control trials, two cohort and six pre‐post studies were eligible for inclusion and were assessed for methodological quality and had data extracted. The greatest initial weight loss was −22 kg, after 16 weeks of a very low energy diet. Greatest weight loss after follow up was −13.1 ± 8.0 kg and 9.1 ± 9.7 kg (7.7 ± 8.1%) after 1 and 2 years, respectively. Studies comparing the effects in males versus females yielded conflicting results. Very low‐energy diets are effective for producing short‐term weight loss. However not all initial weight loss is maintained long term.Conclusion:  Future studies using very low‐energy diets should conduct more rigorous analyses of dietary adherence and physical activity and should be required to document side effects experienced in order to identify how and for whom they are effective in facilitating long‐term weight loss in adults.