bluuebunny/crossref_metadata_2025_split huggingface dataset:
A love that burns: Eroticism, torment and identity at the Palazzo Te
Authors: Maurer Maria F. 
Published: April 2015

AbstractThis essay re‐examines Giulio Romano's Palazzo Te (1525–36) in light of Renaissance attitudes towards eroticism and love. Contrary to a body of scholarship that interprets the building as a hedonistic pleasure palace intended to serve as a meeting place for Federico II Gonzaga and his mistress, I argue that Federico used the Palazzo Te to construct a masculine identity based on Petrarchan notions of love. Erotic and poetic images at the palace were intended to provoke discourse and facilitate masculine homosocial bonding, while the many allusions to Federico's burning desire for his mistress cast the Mantuan ruler as a man ennobled by his tormented love. I argue that Federico purposefully constructed an identity around concepts of tortured subjectivity and ardent love that were circulating in Mantua and abroad. Far from a private retreat, the Palazzo Te was employed by Federico to shape a public princely identity in which his love for his mistress was one means by which he projected his amatory self.
Abortion Counselling in Britain: Understanding the Controversy
Authors: Hoggart Lesley 
Published: April 2015

AbstractThis article reviews literature from a number of disciplines in order to provide an explanation of the political controversy attached to the provision of abortion counselling. It will show how this is an area of health policy debate in which women's reproductive bodies have become a setting for political struggle. The issue of abortion counselling in Britain has undergone a number of discursive shifts in response to political manoeuvring and changing socio‐legal framing of abortion. In particular, the article shows how much of the controversial reframing of abortion counselling was a tactical shift by political actors opposed to abortionper se, and this work is critiqued for not contextualising abortion. The article then focuses on women's abortion experiences and discusses research that shows how women's decision‐making processes, and responses to an abortion, are related to gendered socio‐cultural contexts: the extent to which women having an abortion feel they have transgressed societal norms and values, for example, is likely to affect their abortion experiences. Finally, it is suggested that providing a non‐judgemental context, and challenging negative discourses on abortion, may be the most effective way of minimising the possibility of negative emotions.
Gender Differentiation in Paid and Unpaid Work during the Transition to Parenthood
Authors: Barnes Medora W. 
Published: April 2015

AbstractThe transition to parenthood may be especially difficult because relationships need to be largely reorganized to meet demanding new challenges. For scholars interested in gender inequality, the transition to parenthood is a critical time in which gender differentiation is generated by both economic and cultural forces. Although newly married childless couples tend to share both paid and unpaid labor rather equally, when men and women become parents, their patterns become increasingly differentiated by gender. Cultural beliefs that emphasize mothers as the primary parent and fathers as secondary reinforce unequal patterns in housework and childcare. Time availability models, bargaining perspectives, and gender theories all have been used to explain these patterns. Some changes that could help ease the transition to parenthood include expanding US parental leave policies, improving available childcare, adding flexible work policies, and offering more couples‐focused intervention programs. Although much is known about the topic, more research is needed for the literature to reflect the new generation of global and diverse parents.
Full‐length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis
Authors: Xu Zhichao , Peters Reuben J. , Weirather Jason , Luo Hongmei , Liao Baosheng , Zhang Xin , Zhu Yingjie , Ji Aijia , Zhang Bing , Hu Songnian , Au Kin Fai , Song Jingyuan , Chen Shilin 
Published: April 2015

SummaryDanshen, Salvia miltiorrhiza Bunge, is one of the most widely used herbs in traditional Chinese medicine, wherein its rhizome/roots are particularly valued. The corresponding bioactive components include the tanshinone diterpenoids, the biosynthesis of which is a subject of considerable interest. Previous investigations of the S. miltiorrhiza transcriptome have relied on short‐read next‐generation sequencing (NGS) technology, and the vast majority of the resulting isotigs do not represent full‐length cDNA sequences. Moreover, these efforts have been targeted at either whole plants or hairy root cultures. Here, we demonstrate that the tanshinone pigments are produced and accumulate in the root periderm, and apply a combination of NGS and single‐molecule real‐time (SMRT) sequencing to various root tissues, particularly including the periderm, to provide a more complete view of the S. miltiorrhiza transcriptome, with further insight into tanshinone biosynthesis as well. In addition, the use of SMRT long‐read sequencing offered the ability to examine alternative splicing, which was found to occur in approximately 40% of the detected gene loci, including several involved in isoprenoid/terpenoid metabolism.
Classification of herbicides according to chemical family for weed resistance management strategies – an update
Authors: Forouzesh A , Zand E , Soufizadeh S , Samadi Foroushani S 
Published: April 2015

SummaryThere are inaccuracies in the chemical families of the WSSA and HRAC herbicide classification systems which could limit their practical use in herbicide‐based weed management strategies. In essence, these inaccuracies could be divided into four parts: (i) the nomenclature of many of the chemical families is not correct, (ii) distinct active ingredients are grouped in same chemical families, (iii) many chemical families have been repeated in at least two modes of action/herbicide groups, and (iv) many active ingredients have not been assigned to chemical family, herbicide group or mode of action. The aim of this study was to revise the current classifications and to propose corrections for the current ones. Detailed investigations on chemical structure of the active ingredients of the registered herbicides showed that some moieties have the same mechanisms of action. According to this study, these moieties have been assigned to the names of chemical families and active ingredients are then classified within the chemical families accordingly. This study has 119 chemical families, compared with 145 in the WSSA system and 58 in the HRAC system. A major priority of this study is the number of active ingredients covered; we included 410 active ingredients with known mechanisms of action and herbicide groups, more than 100 active ingredients more than the current classification systems. Overall, this study provides better opportunities for the management of resistance to herbicides through the application of improved pure and applied knowledge.
Draft Genome Sequences of 53 Genetically Distinct Isolates of Bordetella bronchiseptica Representing 11 Terrestrial and Aquatic Hosts
Authors: Register Karen B. , Ivanov Yury V. , Jacobs Nathan , Meyer Jessica A. , Goodfield Laura L. , Muse Sarah J. , Smallridge William E. , Brinkac Lauren , Kim Maria , Sanka Ravi , Harvill Eric T. , Losada Liliana 
Published: April 2015

ABSTRACT

Bordetella bronchiseptica
infects a variety of mammalian and avian hosts. Here, we report the genome sequences of 53 genetically distinct isolates acquired from a broad range of terrestrial and aquatic animals. These data will greatly facilitate ongoing efforts to better understand the evolution, host adaptation, and virulence mechanisms of
B. bronchiseptica
.
Genome Sequences of Three Helicobacter pylori Strains from Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Authors: Wang Hsuan-Chen , Cheng Feng-Chi , Wu Ming-Shiang , Shu Hung-Yu , Sun H. Sunny , Wang Yu-Chun , Su Ih-Jen , Wu Chi-Jung 
Published: April 2015

ABSTRACT

Most of the published complete genome sequences of
Helicobacter pylori
strains are limited to clinical isolates associated with gastritis, peptic ulcers, or gastric cancer. The genome sequences of three
H. pylori
strains isolated from patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma are presented here to facilitate studies of
H. pylori
-associated MALT lymphomagenesis.
Genome Sequence of Methanosarcina soligelidi SMA-21, Isolated from Siberian Permafrost-Affected Soil
Authors: Alawi Mashal , Shapiro Nicole , Woyke Tanja , Horn Fabian , Bakermans Corien , Wagner Dirk 
Published: April 2015

ABSTRACT

Here, we announce the genome sequence of
Methanosarcina soligelidi
SMA-21, an anaerobic methanogenic archaeon that was previously isolated from Siberian permafrost-affected soil. The sequencing of strain SMA-21 yielded a 4.06-Mb genome with 41.5% G+C content, containing a total of 2,647 open reading frames.
Complete Genome Sequence of Duck Tembusu Virus Isolated from Pekin Ducks in Shanghai, China
Authors: Cheng Yuqiang , Zhang Chuanpeng , Wang Hengan , Yan Yaxian , Ding Chan , Sun Jianhe 
Published: April 2015

ABSTRACT
We report here the complete genomic sequence of the duck Tembusu virus (DTMUV) SH001 strain, isolated from Pekin ducks in Shanghai, China, in 2013. The genome of SH001 is 10,990 nucleotides (nt) in length and contains a single open reading frame encoding a putative polyprotein of 3,425 amino acids.
Genome Sequence of Acidovorax citrulli Group 1 Strain pslb65 Causing Bacterial Fruit Blotch of Melons
Authors: Wang Tielin , Sun Baixin , Yang Yuwen , Zhao Tingchang 
Published: April 2015

ABSTRACT

Acidovorax citrulli
is typed into two groups, mainly based on the host. We determined the draft genome of
A. citrulli
group 1 strain pslb65. The strain was isolated from melon collected from Xinjiang province, China. The
A. citrulli
pslb65 genome contains 4,903,443 bp and has a G+C content of 68.8 mol%.
Genome Sequence of Jannaschia aquimarina GSW-M26, a Member of the
Roseobacter
Clade
Authors: Voget Sonja , Díaz Valerio Stefani Maria , von Hoyningen-Huene Avril Jean Elisabeth , Nattramilarasu Praveen Kumar , Vollheyde Katharina , Xiao Shengbin , Daniel Rolf 
Published: April 2015

ABSTRACT

The Gram-negative alphaproteobacterium
Jannaschia aquimarina
GSW-M26 (DSM 28248) is a member of the
Roseobacter
clade. The size of the draft genome is 4.1 Mb. Genome analysis revealed the presence of genes encoding a complete gene transfer agent and aerobic anoxygenic photosynthesis. The latter indicated a photoheterotrophic lifestyle.
Genome Sequence of a Versatile Aromatic Hydrocarbon-Degrading Bacterium,
Arthrobacter
sp. W1
Authors: Jiang Yi , Qu Yuanyuan , Xu Ping , Tang Hongzhi 
Published: April 2015

ABSTRACT

Arthrobacter
sp. W1 is a versatile aromatic-degrading strain which can directly or cometabolically degrade various organic pollutants, such as phenol, naphthalene, carbazole, dibenzofuran, and dibenzothiophene. Here, we present a 3.8-Mb draft genome sequence of strain W1, which may provide comprehensive genetic information for the application in environmental pollution remediation.
Interventions with potential to reduce sedentary time in adults: systematic review and meta-analysis
Authors: Martin Anne , Fitzsimons Claire , Jepson Ruth , Saunders David H , van der Ploeg Hidde P , Teixeira Pedro J , Gray Cindy M , Mutrie Nanette 
Published: April 2015

ContextTime spent in sedentary behaviours (SB) is associated with poor health, irrespective of the level of physical activity. The aim of this study was to evaluate the effect of interventions which included SB as an outcome measure in adults.MethodsThirteen databases, including The Cochrane Library, MEDLINE and SPORTDiscus, trial registers and reference lists, were searched for randomised controlled trials until January 2014. Study selection, data extraction and quality assessment were performed independently. Primary outcomes included SB, proxy measures of SB and patterns of accumulation of SB. Secondary outcomes were cardiometabolic health, mental health and body composition. Intervention types were categorised as SB only, physical activity (PA) only, PA and SB or lifestyle interventions (PA/SB and diet).ResultsOf 8087 records, 51 studies met the inclusion criteria. Meta-analysis of 34/51 studies showed a reduction of 22 min/day in sedentary time in favour of the intervention group (95% CI −35 to −9 min/day, n=5868). Lifestyle interventions reduced SB by 24 min/day (95% CI −41 to −8 min/day, n=3981, moderate quality) and interventions focusing on SB only by 42 min/day (95% CI −79 to −5 min/day, n=62, low quality). There was no evidence of an effect of PA and combined PA/SB interventions on reducing sedentary time.ConclusionsThere was evidence that it is possible to intervene to reduce SB in adults. Lifestyle and SB only interventions may be promising approaches. More high quality research is needed to determine if SB interventions are sufficient to produce clinically meaningful and sustainable reductions in sedentary time.
Medium-term cost-effectiveness of an automated non-invasive ventilation outpatient set-up versus a standard fixed level non-invasive ventilation inpatient set-up in obese patients with chronic respiratory failure: a protocol description
Authors: Mandal S , Arbane G , Murphy P , Elliott M W , Janssens J P , Pepin J L , Muir J F , Cuvelier A , Polkey M , Parkin D , Douiri A , Hart N 
Published: April 2015

IntroductionObesity is an escalating issue, with an accompanying increase in referrals of patients with obesity-related respiratory failure. Currently, these patients are electively admitted to hospital for initiation of non-invasive ventilation (NIV), but it is unknown whether outpatient initiation is as effective as inpatient set-up. We hypothesise that outpatient set-up using an autotitrating NIV device will be more cost-effective than a nurse-led inpatient titration and set-up.Methods and analysisWe will undertake a multinational, multicentre randomised controlled trial. Participants will be randomised to receive the usual inpatient set-up, which will include nurse-led initiation of NIV or outpatient set-up with an automated NIV device. They will be stratified according to the trial site, gender and previous use of NIV or continuous positive airway pressure. Assuming a 10% dropout rate, a total sample of 82 patients will be required. Cost-effectiveness will be evaluated using standard treatment costs and health service utilisation as well as health-related quality of life measures (severe respiratory insufficiency (SRI) and EuroQol-5 dimensions (EQ-5D)). A change in the SRI questionnaire will be based on the analysis of covariance adjusting for the baseline measurements between the two arms of patients.Ethics and disseminationThis study has been approved by the Westminster National Research Ethics Committee (11/LO/0414) and is the trial registered on the UKCRN portfolio. The trial is planned to start in January 2015 with publication of the trial results in 2017.Trial registration numberISRCTN 51420481.
The role of cognitive function in the relationship between age and health literacy: a cross-sectional analysis of older adults in Chicago, USA
Authors: Kobayashi Lindsay C , Smith Samuel G , O'Conor Rachel , Curtis Laura M , Park Denise , von Wagner Christian , Deary Ian J , Wolf Michael S 
Published: April 2015

ObjectivesTo investigate how 3 measures of health literacy correlate with age and the explanatory roles of fluid and crystallised cognitive abilities in these relationships among older adults.DesignCross-sectional baseline analysis of the ‘LitCog’ cohort study.Setting1 academic internal medicine clinic and 5 federally qualified health centres in Chicago, USA.ParticipantsEnglish-speaking adults (n=828) aged 55–74 years, recruited from August 2008 through October 2011.Outcome measuresHealth literacy was measured by theTest of Functional Health Literacy in Adults(TOFHLA) and theNewest Vital Sign(NVS), both of which assess reading comprehension and numeracy in health contexts, and by theRapid Estimate of Adult Literacy in Medicine(REALM), which assesses medical vocabulary. Fluid cognitive ability was assessed through the cognitive domains of processing speed, inductive reasoning, and working, prospective and long-term memories, and crystallised cognitive ability through the verbal ability domain.ResultsTOFHLA and NVS scores were lower at ages 70–74 years compared with all other age groups (p<0.05 for both tests). The inverse association between age and TOFHLA score was attenuated from β=−0.39 (95% CI −0.55 to −0.22) to β=−0.06 (95% CI −0.20 to 0.08) for ages 70–74 vs 55–59 years when fluid cognitive ability was added to the model (85% attenuation). Similar results were seen with NVS scores (68% attenuation). REALM scores did not differ by age group (p=0.971). Crystallised cognitive ability was stable across age groups, and did not influence the relationships between age and TOFHLA or NVS performance.ConclusionsHealth literacy skills show differential patterns of age-related change, which may be explained by cognitive ageing. Researchers should select health literacy tests appropriate for their purposes when assessing the health literacy of older adults. Clinicians should be aware of this issue to ensure that health self-management tasks for older patients have appropriate cognitive and literacy demands.
Interprofessional education in the care of people diagnosed with dementia: protocol for a systematic review
Authors: Pelone Ferruccio , Reeves Scott , Ioannides Andreas , Emery Claire , Titmarsh Kumud , Jackson Marcus , Hassenkamp Anne Marie , Greenwood Nan 
Published: April 2015

IntroductionInterprofessional education (IPE) offers a possible way to improve interprofessional collaboration and patient care. Current research addressing the effectiveness of IPE in dementia care is limited. A protocol is described for a systematic review to investigate the evidence for the influence of IPE on collaborative knowledge and skills; interprofessional practice and the delivery of dementia care.Methods and analysisWe will search the following electronic databases: PubMed, EMBASE, The Cochrane Library, PsycINFO CINAHL, Applied Social Sciences Index and Abstracts (ASSIA), ERIC British Education Index (BEI) and the Healthcare Management Information Consortium (HMIC). Additional studies will be identified by manually searching relevant journals and the reference list of selected studies. The selection of the studies, data collection and quality appraisal will be performed independently by two reviewers. Data will be initially analysed through a narrative synthesis method. If a subset of data we analyse appears comparable, we will investigate the possibility of pooling such data via formal meta-analysis analytical techniques.Ethics and disseminationEthics approval will not be required as this is a protocol for a systematic review. This systematic review aims to establish the effectiveness of IPE programmes on collaborative professional practice and the delivery of care for people with dementia. The findings of this systematic review may also identify specific gaps in the evidence informing a future agenda for research, policy and practice. It will be published in a peer-reviewed journal.Trial registration numberPROSPERO CRD42014015075.
Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α
Authors: Kuijpers Marijke J.E. , Mattheij Nadine J.A. , Cipolla Lina , van Geffen Johanna P. , Lawrence Toby , Donners Marjo M.P.C. , Boon Louis , Lievens Dirk , Torti Mauro , Noels Heidi , Gerdes Norbert , Cosemans Judith M.E.M. , Lutgens Esther , Heemskerk Johan W.M. 
Published: April 2015

Objective—
To investigate the roles and signaling pathways of CD40L and CD40 in platelet–platelet interactions and thrombus formation under conditions relevant for atherothrombosis.

Approach and Results—

Platelets from mice prone to atherosclerosis lacking CD40L (
Cd40lg
−/−
Apoe
−/−
) showed diminished α
IIb
β
3
activation and α-granule secretion in response to glycoprotein VI stimulation, whereas these responses of CD40-deficient platelets (
Cd40
−/−
Apoe
−/−
) were not decreased. Using blood from
Cd40lg
−/−
Apoe
−/−
and
Cd40
−/−
Apoe
−/−
mice, the glycoprotein VI-dependent formation of dense thrombi was impaired on atherosclerotic plaque material or on collagen, in comparison with
Apoe
−/−
blood. In all genotypes, addition of CD40L to the blood enhanced the growth of dense thrombi on plaques and collagen. Similarly, CD40L enhanced glycoprotein VI–induced platelet aggregation, even with platelets deficient in CD40. This potentiation was antagonized in
Pik3cb
R/R
platelets or by inhibiting phosphatidylinositol 3-kinase β (PI3Kβ). Addition of CD40L also enhanced collagen-induced Akt phosphorylation, which was again antagonized by absence or inhibition of PI3Kβ. Finally, platelets from
Chuk1
A/A
Apoe
−/−
mice deficient in IκB kinase α (IKKα), implicated in CD40 signaling to nuclear factor (NF) κB, showed unchanged responses to CD40L in aggregation or thrombus formation.

Conclusions—

Under atherogenic conditions, CD40L enhances collagen-induced platelet–platelet interactions by supporting integrin α
IIb
β
3
activation, secretion and thrombus growth via PI3Kβ, but not via CD40 and IKKα/NFκB. This role of CD40L exceeds the no more than modest role of CD40 in thrombus formation.
GLP-1 Receptor Agonist Exenatide Increases Capillary Perfusion Independent of Nitric Oxide in Healthy Overweight Men
Authors: Smits Mark M. , Muskiet Marcel H.A. , Tonneijck Lennart , Kramer Mark H.H. , Diamant Michaela , van Raalte Daniël H. , Serné Erik H. 
Published: April 2015

Objective—
The insulinotropic gut–derived hormone glucagon-like peptide-1 (GLP-1) increases capillary perfusion via a nitric oxide–dependent mechanism in rodents. This improves skeletal muscle glucose use and cardiac function. In humans, the effect of clinically used GLP-1 receptor agonists (GLP-1RAs) on capillary density is unknown. We aimed to assess the effects of the GLP-1RA exenatide on capillary density as well as the involvement of nitric oxide in humans.

Approach and Results—

We included 10 healthy overweight men (age, 20–27 years; body mass index, 26–31 kg/m
2
). Measurements were performed during intravenous infusion of placebo (saline 0.9%), exenatide, and a combination of exenatide and the nonselective nitric oxide–synthase inhibitor
l
-
N
G
-monomethyl arginine. Capillary videomicroscopy was performed, and baseline and postocclusive (peak) capillary densities were counted. Compared with placebo, exenatide increased baseline and peak capillary density by 20.1% and 8.3%, respectively (both
P
=0.016). Concomitant
l
-
N
G
-monomethyl arginine infusion did not alter the effects of exenatide. Vasomotion was assessed using laser Doppler fluxmetry. Exenatide nonsignificantly reduced the neurogenic domain of vasomotion measurements (
R
=−5.6%;
P
=0.092), which was strongly and inversely associated with capillary perfusion (
R
=−0.928;
P
=0.036). Glucose levels were reduced during exenatide infusion, whereas levels of insulin were unchanged.

Conclusions—
Acute exenatide infusion increases capillary perfusion via nitric oxide–independent pathways in healthy overweight men, suggesting direct actions of this GLP-1RA on microvascular perfusion or interaction with vasoactive factors.