bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinician characteristics, communication, and patient outcome in oncology: a systematic review
Authors: De Vries A. M. M. , de Roten Y. , Meystre C. , Passchier J. , Despland J.‐N. , Stiefel F. 
Published: November 2013

AbstractObjectiveThe aim of this study was to review the literature on clinician characteristics influencing patient–clinician communication or patient outcome in oncology.MethodsStudies investigating the association of clinician characteristics with quality of communication and with outcome for adult cancer patients were systematically searched in MEDLINE, PSYINFO, PUBMED, EMBASE, CINHAL, Web of Science and The Cochrane Library up to November 2012. We used the preferred reporting items for systematic reviews and meta‐analyses statement to guide our review. Articles were extracted independently by two of the authors using predefined criteria.ResultsTwenty seven articles met the inclusion criteria. Clinician characteristics included a variety of sociodemographic, relational, and personal characteristics. A positive impact on quality of communication and/or patient outcome was reported for communication skills training, an external locus of control, empathy, a socioemotional approach, shared decision‐making style, higher anxiety, and defensiveness. A negative impact was reported for increased level of fatigue and burnout and expression of worry. Professional experience of clinicians was not related to communication and/or to patient outcome, and divergent results were reported for clinician gender, age, stress, posture, and confidence or self‐efficacy.ConclusionsVarious clinician characteristics have different effects on quality of communication and/or patient outcome. Research is needed to investigate the pathways leading to effective communication between clinicians and patients. Copyright © 2013 John Wiley & Sons, Ltd.
Effect of subdomain interactions on methyl group dynamics in the hydrophobic core of villin headpiece protein
Authors: Vugmeyster Liliya , Do Tien , Ostrovsky Dmitry , Fu Riqianq 
Published: November 2013

AbstractThermostable villin headpiece protein (HP67) consists of the N‐terminal subdomain (residues 10–41) and the autonomously folding C‐terminal subdomain (residues 42–76) which pack against each other to form a structure with a unified hydrophobic core. The X‐ray structures of the isolated C‐terminal subdomain (HP36) and its counterpart in HP67 are very similar for the hydrophobic core residues. However, fine rearrangements of the free energy landscape are expected to occur because of the interactions between the two subdomains. We detect and characterize these changes by comparing the µs‐ms time scale dynamics of the methyl‐bearing side chains in isolated HP36 and in HP67. Specifically, we probe three hydrophobic side chains at the interface of the two subdomains (L42, V50, and L75) as well as at two residues far from the interface (L61 and L69). Solid‐state deuteron NMR techniques are combined with computational modeling for the detailed characterization of motional modes in terms of their kinetic and thermodynamic parameters. The effect of interdomain interactions on side chain dynamics is seen for all residues but L75. Thus, changes in dynamics because of subdomain interactions are not confined to the site of perturbation. One of the main results is a two‐ to threefold increase in the value of the activation energies for the rotameric mode of motions in HP67 compared with HP36. Detailed analysis of configurational entropies and heat capacities complement the kinetic view of the degree of the disorder in the folded state.
Synthesis and thermoelectric properties of Cu excess Cu2ZnSnSe4
Authors: Dong Yongkwan , Wang Hsin , Nolas George S. 
Published: November 2013

AbstractQuaternary stannites with an excess of copper were successfully synthesized by reacting the constituent elements and subsequent solid state annealing, followed by densification by hot‐pressing. The composition for each specimen was confirmed with a combination of Rietveld refinement and elemental analysis. Their high temperature thermoelectric properties were measured from 300 K to 800 K and compared with that of Cu2ZnSnSe4. The thermal conductivity decreases significantly with increasing Cu content at elevated temperatures due to the crystal structure of this material system. A maximum ZT value of 0.86 was obtained at 800 K for the specimen with the highest Cu content, Cu2.2Zn0.8SnSe4. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Enhancing information lookup privacy through homomorphic encryption
Authors: Fotiou N. , Trossen D. , Marias G.F. , Kostopoulos A. , Polyzos G.C. 
Published: November 2013

ABSTRACTRevealing one's interests in communication has been recognized as a growing problem in the Internet. We postulate that it is desirable for future information retrieval systems to provide privacy in both what information is requested and what information is received, without raising obstacles to the deployment of accounting and access control mechanisms. This paper outlines a solution that fulfills this requirement in the context of broker‐based systems, that is, systems in which brokers facilitate the communication between a consumer and a provider (of information). Broker‐assisted communication is a common paradigm used in many settings, including contemporary information‐centric networking approaches. We present the design and the evaluation of a solution that conceals consumers' interests, without hiding consumer identity or location. The developed solution is applied over a system of hierarchically organized brokers; similar systems are used in many information lookup services. Because in these systems, information is distributed in various locations, traditional private information retrieval (PIR) protocols exhibit significant communication overhead. Our solution achieves up to 97% less communication overhead compared with a PIR protocol, without additional computational overhead. Copyright © 2013 John Wiley & Sons, Ltd.
Autosomal Dominant Inheritance of Brain Cardiolipin Fatty Acid Abnormality in VM/DK Mice: Association with Hypoxic‐Induced Cognitive Insensitivity
Authors: Ta Nathan L. , Jia Xibei , Kiebish Michael , Seyfried Thomas N. 
Published: November 2013

AbstractCardiolipin is a complex polyglycerol phospholipid found almost exclusively in the inner mitochondrial membrane and regulates numerous enzyme activities especially those related to oxidative phosphorylation and coupled respiration. Abnormalities in cardiolipin can impair mitochondrial function and bioenergetics. We recently demonstrated that the ratio of shorter chain saturated and monounsaturated fatty acids (C16:0; C18:0; C18:1) to longer chain polyunsaturated fatty acids (C18:2; C20:4; C22:6) was significantly greater in the brains of adult VM/DK (VM) inbred mice than in the brains of C57BL/6 J (B6) mice. The cardiolipin fatty acid abnormalities in VM mice are also associated with alterations in the activity of mitochondrial respiratory complexes. In this study we found that the abnormal brain fatty acid ratio in the VM strain was inherited as an autosomal dominant trait in reciprocal B6 × VM F1 hybrids. To evaluate the potential influence of brain cardiolipin fatty acid composition on cognitive sensitivity, we placed the parental B6 and VM mice and their reciprocal male and female B6VMF1 hybrid mice (3‐month‐old) in a hypoxic chamber (5 % O2). Cognitive awareness (conscientiousness) under hypoxia was significantly lower in the VM parental mice and F1 hybrid mice (11.4 ± 0.4 and 11.0 ± 0.4 min, respectively) than in the parental B6 mice (15.3 ± 1.4 min), indicating an autosomal dominant inheritance like that of the brain cardiolipin abnormalities. These findings suggest that impaired cognitive awareness under hypoxia is associated with abnormalities in neural lipid composition.
Changes in Young Children’s Family Structures and Child Care Arrangements
Authors: Crosnoe Robert , Prickett Kate Chambers , Smith Chelsea , Cavanagh Shannon 
Published: November 2013

AbstractFamily structure change can disrupt the settings of children’s daily lives. Most scholarship focuses on disruption in the home environment. Moving beyond the home, this study explores the association between changes in family structure and changes in several dimensions of early child care. With longitudinal data from the NICHD Study of Early Child Care and Youth Development (n = 1,298), first-difference models reveal that family structure transitions are associated with changes in the type and quantity of early care as well as the number of care arrangements used, especially during the latter part of infancy. Given prior evidence linking these child care dimensions to behavioral and cognitive outcomes, these results suggest a policy-relevant mechanism by which family change may create inequalities among children.
Regional soil erosion in response to land use and increased typhoon frequency and intensity, Taiwan
Authors: Montgomery David R. , Huang Michelle Y.-F. , Huang Alice Y.-L. 
Published: November 2013

AbstractReservoir sedimentation data and sediment yields from Taiwanese rivers show increased soil erosion in response to both 20th century changes in land use and a more recent increase in typhoon frequency and intensity. Decadal variations of up to 5- to 20-fold in suspended-sediment rating curves demonstrate supply-limited transport and correspond to increased sediment delivery from hillslopes due to changes in land use, regional ground shaking during the Chi-Chi earthquake, and post-2000 changes in typhoon frequency and intensity. While accelerated erosion in central Taiwan after the Chi-Chi earthquake has been documented previously, our results show that periods of increased upland erosion also occurred earlier, in response to 20th century changes in land use. Analyses of rainfall records and typhoon frequency for the period 1900–2009 further point to an island-wide increase in erosion rates corresponding to increased typhoon frequency and intensity after 1990.
Smoothness in Relative Geometry
Authors: Marty Florian 
Published: November 2013

AbstractIn [TVa], Bertrand Toën and Michel Vaquié defined a scheme theory for a closed monoidal category ( ⊗1). In this article, we define a notion of smoothness in this relative (and not necessarily additive) context which generalizes the notion of smoothness in the category of rings. This generalisation consists in replacing homological finiteness conditions by homotopical ones, using the Dold-Kan correspondence. To do this, we provide the category s of simplicial objects in a monoidal category and all the categories sA-mod, sA-alg (A ∈ sComm()) with compatible model structures using the work of Rezk [R]. We then give a general notion of smoothness in sComm(). We prove that this notion is a generalisation of the notion of smooth morphism in the category of rings and is stable under composition and homotopy pushouts. Finally we provide some examples of smooth morphisms, in particular in ℕ-alg and Comm(Set).
HELPING FARMERS ADAPT TO CLIMATE AND CROPPING SYSTEM CHANGE THROUGH INCREASED ACCESS TO SORGHUM GENETIC RESOURCES ADAPTED TO PREVALENT SORGHUM CROPPING SYSTEMS IN BURKINA FASO
Authors: VOM BROCKE KIRSTEN , TROUCHE GILLES , WELTZIEN EVA , KONDOMBO-BARRO CLARISSE P. , SIDIBÉ ADAMA , ZOUGMORÉ ROBERT , GOZÉ ERIC 
Published: November 2013

SUMMARYSorghum (Sorghum bicolor(L.) Moench) is a major staple crop of Burkina Faso where farmers continue to cultivate photoperiod-sensitive guinea landraces as part of the strategy to minimize risk and ensure yield stability. In the Boucle du Mouhoun region, however, sorghum farmers appear to have insufficient varietal choice due to cropping systems having shifted towards more intensive cultivation of cotton and maize, and rainfall patterns having decreased over the past decade. In search for new varietal options that can respond to this changing context, researchers decided to give farmers access to ex-situ national collections along with the opportunity to evaluate recent improved varieties. From 2002 to 2007, researchers and farmers worked closely together to implement on-farm testing, including varietal selection trials, crop management and multi-locational trials. Farmers’ choices tend to differ among groups, villages and years, with the exception of four particular landraces: two originating from a collection carried out in the Mouhoun region more than 30 years previous to this research, and two other landraces that came from the dissimilar agro-ecological zones of Burkina Faso. These four were the most commonly selected landraces out of 36 cultivars that covered both improved and landrace varieties. Farmers’ selection criteria were focused on adaptation to agro-climatic conditions as well as specific grain qualities for processing and consumption. The potential usefulness of each variety was verified via multi-locational trials. The paper also shows that wide dissemination of experimental seed, not just across the Mouhoun region but also at a national scale, was largely achieved through collaboration with a strong farmer organisation in conjunction with farmer training programs focused on the on-farm seed production and the commercialisation of this seed.
P300 waveform and dopamine transporter availability: a controlled EEG and SPECT study in medication-naive patients with schizophrenia and a meta-analysis
Authors: Chen K. C. , Lee I. H. , Yang Y. K. , Landau S. , Chang W. H. , Chen P. S. , Lu R. B. , David A. S. , Bramon E. 
Published: November 2013

BackgroundReduced P300 event-related potential (ERP) amplitude and latency prolongation have been reported in patients with schizophrenia compared to healthy controls. However, the influence of antipsychotics (and dopamine) on ERP measures are poorly understood and medication confounding remains a possibility.MethodWe explored ERP differences between 36 drug-naive patients with schizophrenia and 138 healthy controls and examined whether P300 performance was related to dopamine transporter (DAT) availability, both without the confounding effects of medication. We also conducted a random effects meta-analysis of the available literature, synthesizing the results of three comparable published articles and our local study.ResultsNo overall significant difference was found in mean P300 ERP between patients and controls in latency or in amplitude. There was a significant gender effect, with females showing greater P300 amplitude than males. A difference between patients and controls in P300 latency was evident with ageing, with latency increasing faster in patients. No effect of DAT availability on P300 latency or amplitude was detected. The meta-analysis computed the latency pooled standardized effect size (PSES; Cohen's d) of −0.13 and the amplitude PSES (Cohen's d) of 0.48, with patients showing a significant reduction in amplitude.ConclusionsOur findings suggest the P300 ERP is not altered in the early stages of schizophrenia before medication is introduced, and the DAT availability does not influence the P300 ERP amplitude or latency. P300 ERP amplitude reduction could be an indicator of the progression of illness and chronicity.
Private protected areas: three key challenges
Authors: LADLE RICHARD J. , BRAGAGNOLO CHIARA , GAMA GABRIELA M. , MALHADO ANA C.M. , ROOT-BERNSTEIN MEREDITH , JEPSON PAUL 
Published: November 2013

SUMMARYPrivate protected areas (PPAs) are a board category that includes reserves established and managed by non-government entities, including civil society organizations, businesses and private individuals. It was recently suggested that the creation of a system of PPAs in Brazil may act as a useful model for extending protected area systems internationally. While it is clear that RPPNs have an important role to play in the future development of Brazil's protected area system, there are several significant challenges that need to be overcome if they are fulfil their potential: (1) ensuring that RPPNs contribute to coverage and representation; (2) ensuring adequate governance; and (3) increasing the attractiveness of the RPPN model. While it is still too early to determine whether RPPNs constitute a robust PPA model that could (or should) be exported to other countries, they are creating new opportunities for innovation and novel management strategies that might eventually lead to a vibrant and distinctly Brazilian protected area movement.
Gamete quality in fish: evaluation parameters and determining factors
Authors: Valdebenito Iván I. , Gallegos Patricia C. , Effer Brian R. 
Published: November 2013

SummaryThe quality of fish gametes, both male and female, are determined by several factors (age, management, feeding, chemical and physical factors, water quality, etc.) that have an impact on the survivability of embryos, larvae and/or fry in the short or long term. One of the most important factors is gamete ageing, especially for those species that are unable to spawn naturally in hatcheries. The chemical and physical factors in hatcheries and the nutrition that they provide can significantly alter harvest quality, especially from females; as a rule, males are more tolerant of stress conditions produced by inadequate feeding, management and/or poor water conditions. The stress produced on broodstock by inadequate conditions in hatcheries can produce adverse effects on gamete quality, survival rates, and the embryonic eggs after hatching.
Expression of phosphatidylcholine biosynthetic enzymes during early embryogenesis in the amphibianBufo arenarum
Authors: Fernández-Bussy Rodrigo , Mouguelar Valeria , Banchio Claudia , Coux Gabriela 
Published: November 2013

SummaryIn the principal route of phosphatidylcholine (PC) synthesis the regulatory steps are catalysed by CTP:phosphocholine cytidylyltransferase (CCT) and choline kinase (CK). Knock-out mice inPcyt1a(CCT gene) andChka1(CK gene) resulted in preimplantation embryonic lethality, demonstrating the essential role of this pathway. However, there is still a lack of detailed CCT and CK expression analysis during development. The aim of the current work was to study the expression during early development of both enzymes in the external-fertilization vertebrateBufo arenarum. Reverse transcription polymerase chain reaction (RT-PCR) and western blot confirmed their presence in unfertilized eggs. Analysis performed in total extracts from staged embryos showed constant protein levels of both enzymes until the 32-cell stage: then they decreased, reaching a minimum in the gastrula before starting to recover. CTP:phosphocholine cytidylyltransferase is an amphitropic enzyme that inter-converts between cytosolic inactive and membrane-bound active forms. Immunoblot analysis demonstrated that the cytosolic:total CCT protein ratio does not change throughout embryogenesis, suggesting a progressive decline of CCT activity in early development. However, PC (and phosphatidylethanolamine) content per egg/embryo remained constant throughout the stages analysed. In conclusion, the current data forB. arenarumsuggest that net synthesis of PC mediated by CCT and CK is not required in early development and that supplies for membrane biosynthesis are fulfilled by lipids already present in the egg/embryo reservoirs.
Anti-NMDA receptor encephalitis: Psychiatric presentation and diagnostic challenges from psychosomatic medicine perspective
Authors: Gulyayeva Nataliya A. , Massie Mary Jane , Duhamel Katherine N. 
Published: November 2013

AbstractWe describe two cases of confirmed anti-NMDA receptor encephalitis; one patient initially presented with a clinical picture that resembled delirium and later appeared to present with a conversion reaction and the second patient presented with a first psychotic break followed by the clinical picture of neuroleptic malignant syndrome with catatonia. Neither patient had a previous history of psychiatric illness or recreational drug use. These cases illustrate the diagnostic and treatment challenges associated with this neuropsychiatric condition and underscore the role of psychosomatic medicine psychiatrists in diagnosing anti-NMDA receptor encephalitis.
SeqDepot: streamlined database of biological sequences and precomputed features
Authors: Ulrich Luke E. , Zhulin Igor B. 
Published: November 2013

Abstract
Summary: Assembling and/or producing integrated knowledge of sequence features continues to be an onerous and redundant task despite a large number of existing resources. We have developed SeqDepot—a novel database that focuses solely on two primary goals: (i) assimilating known primary sequences with predicted feature data and (ii) providing the most simple and straightforward means to procure and readily use this information. Access to &gt;28.5 million sequences and 300 million features is provided through a well-documented and flexible RESTful interface that supports fetching specific data subsets, bulk queries, visualization and searching by MD5 digests or external database identifiers. We have also developed an HTML5/JavaScript web application exemplifying how to interact with SeqDepot and Perl/Python scripts for use with local processing pipelines.
Availability: Freely available on the web at http://seqdepot.net/. REST access via http://seqdepot.net/api/v1. Database files and scripts may be downloaded from http://seqdepot.net/download.
Contact: ulrich.luke+sci@gmail.com
Renaissance of a caveat: Allee effects in marine fish
Authors: Hutchings Jeffrey A. 
Published: November 2013

AbstractThe population dynamics of marine fish at low abundance has long been of interest. One century ago, Johan Hjort drew attention to the importance of understanding “the laws which govern the renewal of the animal population”. Integral to the current work on the recovery of collapsed fish stocks is the association between abundance and per capita population growth rate (r), a negative correlation being representative of compensation and a positive correlation indicative of an Allee effect, also termed depensation. Allee effects are predicted to slow the rate, and increase the uncertainty, of recovery. Based on studies having sufficient data at low abundance, the magnitude of depletion experienced by some fish populations appears to have been sufficient to have generated either an Allee effect or a transition from strong to weak (or absent) compensatory dynamics. To a first approximation, empirically based Allee-effect reference points are consistent with suggested thresholds for overfishing and stock collapse. When evaluating Allee effects in marine fish, it is important not to conflate causal mechanism(s) with the pattern between r and abundance; the latter is of greater practical import. An additional caveat is that the longer a population remains at low abundance, the more likely it is that the environment around it will change in ways that are unfavourable to recovery. It might be this “temporal tyranny” of small population size that is most likely to produce an emergent Allee effect and depensatory dynamics in some collapsed marine fish populations.