bluuebunny/crossref_metadata_2025_split huggingface dataset:
1862 – The Effects Of Eeg-neurofeedback On Adhd Symptoms And Eeg Parameters
Authors: Flisiak-Antonijczuk H. , Kalinowski R. , Adamowska S. , Nowak M. , Piątak P. 
Published: July 2013

IntroductionEEG-neurofeedback is used as a component of therapy in patients diagnosed with ADHD. The efficacy of NF on inattentive symptoms has been previously suggested.ObjectiveThe aim of the study was to assess the efficacy of 20 sessions training of eeg-neurofeedback (NF) in patients suffered from ADHD.MethodsThe studied group consisted of 44 patients (34 boys and 7 girls).To determine the efficacy of EEG-B on symptoms intensity, The Symptoms of ADHD Questionnaire was used: before the treatment and after 20 sessions of NF. NF trainings took place once or twice a week. The trainings were conduct based on two protocols: theta/beta and theta/SMR for left hemisphere and for right hemisphere, respectively. The changes in theta/beta and theta/SMR ratios were estimated to assess the influence of NF on eeg parameters.ResultsThe significant reduction in symptoms intensity was found after 20 sessions of NF. Theta/beta and theta/SMR ratios median values have been significantly decreased.ConclusionsThe results of the study indicate the 20 sessions NF training being efficacious in reduction of the intensity of ADHD symptoms. The improvement of eeg parameters responsible for attention functions was also observed.
1864 – Sexual Orientation And Depression Among Young Adult People
Authors: Wiszniewicz A. , Wojtyna E. 
Published: July 2013

IntroductionNon-heterosexual orientations are widely stigmatized and frequently exposed to discrimination and victimization. Stigma has an impact on the formation of minority stress which base on the premise that non-heterosexuals in the society are subjected to chronic stress. This is a cause of the occurrence many psychological problems including depression among homosexual and bisexual individuals.AimsThis study examined the relationship between sexual orientation and level of depression among young adult people.MethodsThe designed cross-sectional survey was used. The study comprised 316 participants who declare themselves as heterosexual (n=98), homosexual (n=160) and bisexual (n=58). The following questionnaire methods were used: the Beck Depression Inventory and self-report questionnaire including items about demographic characteristics.ResultsData analyses has shown that 30.7% of surveyed non-heterosexual people have a higher risk of depression. It's nearly three times greater than for general Polish population. The research also has distinguished level of depression according to sexual orientation of respondents (bisexual: M=13.22, SD=10.69; homosexual: M=8.85, SD=8.29; heterosexual: M=4.13, SD=3.88). Results present that the highest risk of depression occurs among bisexual individuals (F=3.68, p< 0.01), especially women.ConclusionsSome of the excess depression among non-heterosexuals could be lessened by intervention strictly associated with gender and sexual orientation.
1866 – Novel Candidate Genomic Loci For Mental Retardation
Authors: Kashevarova A. , Salyukova O. , Magini P. , Graziano C. , Romeo G. , Lebedev I. 
Published: July 2013

IntroductionGenetic disorders underlie a significant number of cases of mental retardation (MR). However, the traditionally used routine karyotyping is not able to detect small but often clinically relevant aberrations. High-resolution genome-wide microarray technologies may help to increase the detectability of MR etiology.ObjectivesTo improve MR diagnostics.AimsTo identify the novel CNV regions and susceptibility genes in MR patients.MethodsLarge chromosomal rearrangements, biochemical defects, and known monogenic syndromes accompanied by MR were ruled out for 71 patients. Further the genome-wide analysis using CGH Microarray Kits 4×44K and 8×60K (Agilent Technologies, USA) was performed.ResultsEight novel CNVs in 9 patients not described in healthy individuals and not associated with any disease were indentified implicating regions at 11q22.3, 5q33.1, 3p26.3, 15q11.1-q11.2, 15q22.2, 1q25.1-q25.2, 7q21.3, 2q12.3. They include candidate genes DDX10 (putative RNA helicase), IL17B (cytokine, primarily localized to neuronal cell bodies), CNTN6 (may play a role in the formation of axon connections), TLN2 (plays a role in cell adhesion and recycling of synaptic vesicles), TNR (an extracellular matrix protein, expressed primarily in the central nervous system), ASTN1 (a neuronal adhesion molecule), PON1 (detoxifies organophosphate neurotoxicants), and SLC5A7 (choline transporter in the brain and periphery).ConclusionsPreviously unknown CNVs, containing genes responsible for proper central nervous system functioning, were detected in 13% of patients. The novel CNVs and genes identified by aCGH may help discovering new etiological mechanisms of MR. This study was supported by European Community's Seventh Framework Programme, CHERISH (project 223692) and by Federal Program (grant 8727).
1868 – Psychological Risk Factors In Families Of Autistic Children
Authors: Gouva M. , Dragioti E. , Kitta M. , Albani E. , Bakou E. , Paschou A. , Kotrotsiou E. 
Published: July 2013

IntroductionLarge bodies of work have shown that parents of children with disabilities experienced a disproportionately greater level of stress relating to their children.ObjectivesTo investigate the relationship of shame, psychopathology, hostility as well as anxiety in parents of children with autism.AimTo examine the impact of autism spectrum disorder on the family and compared to with families of diabetic childrenMethodsA community sample of 105 parents of autistic children (36 men - 69 women, mean age 41 years, SD = 6,5 ranged 30-56) and 83 parents of children with diabetes (18 men - 65 women, mean age 41 years, SD = 7 ranged 24-54) participated to the present study. The families were recruited if their children had been diagnosed with autism or diabetes for at least 1 year and had no other comorbid chronic illnesses. No children age restrictions were applied. The two groups were completed a) the Other of Shame scale (OAS) b) the the Experience of Shame Scale (ESS) c) the Symptom Check-List Revised (SCL-90) d) the Hostility and Direction of Hostility Questionnaire (HDHQ) and e) questionnaire concerning socio-demographic information.ResultsAge did not differ significantly among the two groups (t=.016, p=.986). Logistic regression found that significant positive correlations were obtained for certain independent risk factors, namely internal shame (OR= 0.9, 95%CI .85-.92), anxiety (OR=1.35 95%CI 1.09-1.67) and paranoid hostility (OR=1.93, 95%CI 1.28-2.92), after adjusting for sociodemographicrelated variables.ConclusionShame, anxiety and paranoid hostility were found significant for families with a child with autism.
1870 – Factors Of Prognosis Of Formation Of Mental Disorders Co-morbid With Somatic Pathology
Authors: Lebedeva V. 
Published: July 2013

Relevance of the investigation has been conditioned by tendency toward increase of number of patients with mental disorders associated with somatic diseases and related with these questions organization of medico-psychological help and problems of its financing.MaterialPatients with mental disorders associated with somatic pathology addressing specialized psychohygienic help room of general somatic primary care institution. Age of patients was more than 18 years old.MethodsClinical-psychopathological, questionnaire screening, clinical-follow-up, mathematic-statistical.ResultsDuring considering of relationships between somatic diseases and mental disorders we have revealed preference of some somatic pathology in various groups of mental disorders. Specific weight of co-morbid mental pathology has been especially represented in patients with organic mental disorders (100,0%), psychological and behavioral disorders associated with diseases (100,0%) behavioral disorders, conditioned by alcoholism (93,6%). Then there were patients with neurotic, stress-related and somatoform (74,6%) and affective (72,7%) disorders. The least association of somatic pathology has been found in patients with schizophrenia (33?3%) and personality disorders (32,9%). Method of factorial analysis has identified factors as follows: somatovegetative, psychopathologic syndromes and somatic pathology) of formation of combined mental and somatic diseases.ConclusionStructure of somatic diseases reflects common structure of somatic pathology documented in patients of somatic network that is of importance during development of preventive and rehabilitative programs for patients of general somatic care. Clinical picture of current course is characterized by polymorphism, conditioned by combination of somatovegetative and mental disorders.
1874 – The Frequency And Demographic Characteristic Of Depression Without Psychotic Symptoms In The Period Of Two Years
Authors: Licanin I. 
Published: July 2013

IntroductionAccording to the assessment performed by the World Health Organization (WHO), depression will be the second leading disorder in the World, but among the female population will be the first.AimTo analyze and describe the frequency of depression without psychotic symptoms among total number of the patients hospitalized during 2010-2011 at the Psychiatric clinic in Sarajevo; to show some demographic characteristic and duration of the treatment.Patients and methodThis is retrospective-prospective study covered randomly selected 713 hospitalized patients with depression without psychotic symptoms according to diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).ResultsMajority of subjects was aged 50-59 (60%), lower educational level 64 (81%), female 51 (63%). We show in this study number and types of depression without psychotic symptoms, duration of the treatment as well.ConclusionDepression is more frequent among female then among male. Research also show increasing number of subjects younger then 20 yrs due of alcohol and drug abuse.
1881 – Hallucinations And Delusions In a Hospitalized Patient In a Stroke Unit: Seizures Or delirium?
Authors: Frade P. , Sousa D. , Geraldes R. , Bentes C. , Pinho e Melo T. , Maltez J. 
Published: July 2013

IntroductionSometimes psychotic symptoms may occur as a consequence of epileptic discharges. Complex visual hallucinations have been described in patients with occipito-temporal and anteromedial temporal epileptic activity. The potential atypical character of seizures’ manifestations in elderly patients,a reduced tendency to secondary generalization, associated with the high frequency of confusional syndromes, makes the interpretation of perception and thought disturbances a challenge.Case studyPatient 76 years, male gender, with hypertension, light alcohol consumption and without prior history of cognitive impairment. Medicated with benzodiazepines for insomnia (suspended during hospitalization). History of one episode of generalized seizure in his youth. Admitted to the stroke unit with a left occipital hematoma diagnosed after a sudden onset headache. The neurological examination was unremarkable. On the 2nd day of hospitalization initiated episodes of nocturnal restlessness, disorientation and persecutory delusions accompanied by visual and auditory hallucinations which were scenic and stereotyped. This clinical picture was initially interpreted as an acute confusional syndrome and haloperidol was administered. These episodes lasted about 20 minutes and did not respond to therapy. There was interepisodic full recovery and no other clinical or analytical abnormalities. Considering the nature of these episodes an EEG was performed, which revealed right anterior temporal intercritical epileptic activity. Therapy with neuroleptic was discontinued with resolution of symptoms.ConclusionWe intend to point out that in cases of stereotyped hallucinations epileptic etiology should be considered as a differential diagnosis for the clinical pictures with psychotic symptoms, which are often interpreted as acute psychosis or delirium, especially in elderly hospitalized patients.
1883 – Anxiety Personality Traits And Cannabinoid Polymorphisms Genes
Authors: Binelli C. , Batalla A. , Royo I. , Fernández-Aranda F. , Gratacos M. , Subirà S. , Crippa J.A. , Zuardi A.W. , Martín-Santos R. 
Published: July 2013

BackgroundThere is increasing data supporting the role of endocannabinoid system (eCB) in the control of emotional homeostasis, mainly acting through CB1R activation (Menchoulam&Parker, 2012). eCB seems important to maintain baseline anxiety levels and to recovery/adapt to stressful and aversive situations (Moreira&Luz, 2008). A misbalance in eCB system might contribute to the etiology of anxiety related disorders (Crippa et al., 2009; Marco et al., 2012). The cannabinoid receptor 1 (CNR1) gene has been associated to “high neuroticism” and “low agreeableness” phenotype (Juhasz et al., 2009).AimsStudy the association between personality traits and genetic polymorphisms located in genes related to eCB (CNR1, CNR2, FAAH and MGKLL) in patients with anxiety disorders.MethodsIn a case-control study, we analyzed 48 polymophisms tagSNPs in sample of 507 Caucasians subjects of both genders. All were assessed using the Semi-Structural Interview of DSM-IV criteria and the Temperament and Character Inventory of Cloninger. Multiple regression analysis was used to determine whether the different personality traits were associated with each variant in CNr1, CNr2, FAAH, and MGKLL, using age and gender as confounder variables.ResultsA significant association was found between “high Harm-avoidance” trait and rs1049353 in the CNR1 gene (p< 0.005) and rs1157694 in the FAAH gene (p< 0.001). “Low novelty-seeking” trait was associated with rs324490 in the FAAH gene (p< 0.005).ConclusionsThese findings suggest that genetic variations in the CNR1 and FAAH genes may modulate the expression of some clinical aspects of anxiety traits and probably anxiety disorders. Grants: ICIII G03/184; SGR2009/1435.
1892 – Therapeutic Adherence In Depot Medicated Patients
Authors: Roberto A. , Souta J. , Coelho S. , Sales P. , Costa I.R. , Pereira D. 
Published: July 2013

Introduction and objectivesPoor adherence remains a problem in schizophrenic patients. Treatment guidelines for schizophrenia recommend depot medications for patients who are no adherent to oral regimens. This study aims to evaluate subjective experiences, adverse effects and adherence of depot medicated patients.MethodsWas applied a questionnaire composed by the “Drug Attitude Inventory” (subjectively assesses the attitude and experiences of patients towards their depot medication) and by questions about adverse effects with medications. We took into account four different depot formulations: risperidone, haloperidol, fluphenazine and zuclopenthixol.ResultsParticipated 44 schizophrenic patients. The majority is male (77%). Clinically, the mean age of diagnosis is 28 years. About 50% of patients do the long acting risperidone, 31,8% the haloperidol decanoate and 9,1% the fluphenazine or zuclopenthixol. About 52,3% say they do not know the reason they take depot medication and 16% report previous therapeutic abandonment. There are not differences between mean results in “Drug attitude inventory” and all depot medications average in the positive range. Most frequent adverse affects are weight gain (29,5%) and sedation (15,9%). In rating discomfort of adverse affects 54,5% patients score zero (no discomfort) and 2,3% score ten (very uncomfortable) without significant differences between formulations.Discussion/conclusionDespite reporting adverse effects, patients attribute a low score in terms of discomfort. Although some of them report ignore the reason they are taking depot, patients have positive subjective experiences and attitudes with these medications. This fact may be predictive of good compliance.
1895 – Cerebral Opioid Activity In Patients With Restricting-type Anorexia Nervosa Before And After Weight Recovery: a [11c]diprenorphine Pet Study
Authors: Soranzo J. , Costes N. , Germain-Zito N. , Le Bars D. , Billard S. , Lang F. , Estour B. , Galusca B. 
Published: July 2013

IntroductionOpioid peripheral abnormalities were described in anorexia nervosa (AN). Until now no data have been published on cerebral activity of opioid system in these subjects. Diprenorphine is a ligand with non-specific binding to opiates receptors μ, κ and δ.AimTo evaluate in vivo brain opioid receptors binding potential (BP) in patients with lean and recovered from restrictive-type AN by comparison with controls and the relationship with eating-related psychochological and hormonal traits.MethodsIn 17 lean restrictive-type AN patients, 15 recovered AN subjects and 15 age-matched controls we assessed in vivo [11C]Diprenorphine binding by brain positron emission tomography and eating-related psychopathological traits. Inter-groups differences in [11C]Diprenorphine binding were evaluated by voxel-based analyses.ResultsLean restrictive AN and recovered AN patients presented with similar decreased [11C]Diprenorphine binding in bilateral medial frontal cortex and temporo-parietal cortex. We noted a lower BP in hypothalamo-pituitary structures and also in anterior cingulate gyrus in lean AN patients. Additionally, only recovered AN patients presented with a decreased [11C]Diprenorphine binding in caudate nuclei and putamen. Direct correlations were found between the anterior cingulate gyrus BP and mean cortisol and between the left amygdala [11C]Diprenorphine binding and eating concern score.ConclusionThe opioid system is widely affected in AN even after recovery in regions known to be involved in the neurocircuitry of addiction and support the hypothesis of an organic dysfunction in AN.
1897 – Overlapping Orbitofrontal Volume Loss Involved In Stimulant Dependence And Weight Gain
Authors: Smith D.G. , Jones P.S. , Bullmore E.T. , Robbins T.W. , Ersche K.D. 
Published: July 2013

IntroductionStimulant dependence is commonly associated with decreases in cortical volume in inhibitory control regions, such as the orbitofrontal cortex (OFC). Obese individuals similarly show abnormalities in frontal gray matter, with volume reductions correlating with BMI. These structural deficits may contribute to underlying problems with impulsivity or self-control present in both groups.ObjectivesShared structural abnormalities relating to over-consumption of food or drugs of abuse could shed light on similar neurocognitive impairments associated with these behaviors (loss of control, poor decision-making), and could provide evidence for the classification of over-eating as an addictive disorder.AimsTo identify overlapping regions of gray matter volume loss associated with both stimulant dependence and increased BMI, specifically in the OFC.MethodsStructural MRI scans of stimulant dependent and healthy control individuals were compared using voxel based morphometry analysis. OFC volume was correlated with BMI in all participants, as well as years of drug use in stimulant dependent individuals.ResultsBoth stimulant use and BMI negatively correlated with bilateral OFC gray matter volume. Additionally, select OFC regions showed decreases relating to both variables, indicating an overlap between volume loss associated with years of use and BMI in both stimulant dependent and control individuals.ConclusionsOverlapping decreases in OFC gray matter volume that correspond to both overeating and drug use severity indicate underlying commonalities between these two behaviors. This suggests there may be shared cognitive deficits maintained in the OFC, such as poor inhibitory control or decision-making abilities, that preclude these types of behaviors.
1899 – Fear Of Pain And Chronic Low Back Pain: Differences Between Greek Men And Women Patients
Authors: Baliotis K. , Dragioti E. , Korakakis V. , Katri F. , Kotrotsiou E. , Gouva M. 
Published: July 2013

IntroductionChronic pain can lead the subjective emotional pain response of an individual and has the potential to play a very decisive role in determination of pain intensity and pain duration.ObjectiveThis study examined the effect of fear of pain on chronic pain.AimThe present study aimed the relationship of fear of pain with chronic low back pain (CLBP) and the differences between genders of patients with CLBP.Materials and methodsTwo hundred and one patients with CLBP participated in the present study (53 men - 148 women, mean age±SD 37,4 ± 13,7). The measures used were: Fear of Pain Questionnaire - FPQ-III (McNeil & Rainwater, 1998) and another questionnaire with socio-demographics, attitudes and self-reported questions data on the impact of the chronic pain in their life.ResultsThe mean scores (±SD) for men and women with CLBP and the p values from the T-tests were respectively: for total FPQ-III, 67,92 ± 17,46 and 78,48 ± 18,88, (P=0,000), for minor pain 16,06 ± 5,02 and 19,56 ± 6,19, (P=0,000), for severe pain 30,74 ± 8,42 and 34,82± 7,57, (P=0,001), and for medical pain 21,13 ± 7,66 and 23,91 ± 8,54, (P=0,038),ConclusionThe results of the present study revealed the high levels of fear of pain in patients with CLBP. Furthermore, the gender was established as another potential variable that is related to isolated differences in emotional responses to pain.
1902 – Feasibility Of Centralized Ratings For Mental Health Safety Screening In a Non-psychiatric Clinical Trial
Authors: Williams J.B.W. , Davis D. , Popp D. , Gross J.A. , Salvucci D. , Detke M.J. 
Published: July 2013

IntroductionCentralized ratings by telephone have proven feasible for assessment of psychiatric diagnosis, symptom severity, and suicidality, and may be used for safety assessments in non-psychiatric trials with sites that do not employ staff experienced in psychiatric assessment.ObjectiveTo assess whether centralizing assessments with mental health experts enables immediate clinical follow-up and actionable diagnostic support for investigators.AimsTo examine the feasibility of centralized ratings in a Phase III dermatology clinical trial for safety assessments.Methods1127 subjects enrolled in a trial of medication for their dermatologic condition were assessed via telephone by central raters who administered the SCID-CT, C-SSRS and PHQ-8 at screening. At monthly visits, central raters performed the C-SSRS, PHQ-8, GAD-7 and items designed to detect emergent psychotic symptoms.Results:Screening34 subjects were excluded on the basis of SCID-CT diagnosis. Based on diagnosis or severity, subjects were classified as being in no need of mental health services, having mild psychiatric symptoms (referred to local mental health service provider; n=33), moderate (immediate referral for psychiatric evaluation; n=17), or severe (immediate escort to emergency room; n=0).One subject reported suicidal ideation on the C-SSRS, 10 reported self-injurious behavior, and 5 reported suicidal behavior in the last year.Follow-UpNo subjects reported suicidal ideation or behavior at any of the 6861 follow-up assessments. One subject reported self-injurious behavior and two reported emergent psychotic symptoms.ConclusionsThis study established the feasibility and acceptability of routine screening and monitoring of psychopathology and suicidality by central raters in a non-psychiatric population.