bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vegetation wakes and wake interaction shaping aquatic landscape evolution
Authors: Kondziolka John M. , Nepf Heidi M. 
Published: December 2014

Lay AbstractVegetation found in marshes and tidal systems influences the flow of water through these systems. Vegetation blocks the flow of water, leading to areas of low water velocity immediately downstream of a vegetation patch and areas of high water velocity at the sides of a patch. Areas of lower velocity provide good habitat for young plants and seedlings, and thus encourage plant growth such that the patch expands in the downstream direction. The addition of more vegetation near the original patch further reduces the local velocity that further promotes growth, creating a system of feedbacks. Recently, studies have found that when several patches of vegetation are near each other, they can change the shape and extent of the low‐velocity regions downstream. Based on these findings, the present study develops a model to evaluate how a field of vegetation might evolve over many years and the final distribution patterns that result. The model initially evaluates the water velocity based on a simple theoretical model and then modifies the velocity field to incorporate reduction of flow downstream of the patches, based on laboratory observations. Once the velocity at every point is calculated, vegetation is added probabilistically, with areas of high velocity having a low probability of growth and areas of low velocity having a high probability of growth. The number of initial vegetation patches and the limiting velocity (the velocity above which no plants can grow) were varied, and three different types of landscapes were produced: full vegetation coverage, channeled, and sparse. The effect of vegetation on the velocity field in the wake (i.e., downstream) of the vegetation is shown to accelerate landscape development.
The impact of chronic venous leg ulcers: a systematic review
Authors: Green J. , Jester R. , McKinley R. , Pooler A. 
Published: December 2014

• ObjectiveChronic venous leg ulcers are common, intractable and often recurrent, but care tends to be wound focused, potentially overlooking the significant impact the condition has on patients' lives. A systematic review was undertaken to explore the factors that impact on the quality of life of patients with chronic venous leg ulceration.• MethodEligible articles published between 1990 and 2013 were identified via electronic searches of research databases (MEDLINE, CINAHL, BNI, EMBASE, PsycINFO, AMED and HMIC, Cochrane Collaboration database and Google Scholar).• ResultsThere were 23 studies (11 qualitative and 12 quantitative) that met the inclusion criteria. There were then the subject of a full review. The qualitative studies were collapsed into four core themes: physical, psychological, social implications and the nurse–patient relationship. The quantitative studies were grouped according to the tool applied. The review demonstrated that chronic venous leg ulcers impact negatively upon all areas of daily living. Pain, exudate, odour and the impact on mobility were daily challenges. The ability to engage with everyday functioning was restricted either owing to the ulcer, the dressing or to a self-imposed isolation in response to the impact of symptoms. Depression and low mood were common and yet, despite this, some studies reported that participants remained hopeful.• ConclusionStudies suggest that chronic venous leg ulceration negatively affects the quality of life of the patient and that such issues receive inadequate attention during current consultations. If such negative implications are to be effectively addressed, key issues need to be considered during every consultation.• Declaration of interestThis study was funded by West Midlands Strategic Health Authority. The authors have no conflicts of interest to declare.
Wound swab use and misuse at a regional general hospital
Authors: Fenech M. , Abela R. , Chetcuti Zammit S. , Mercieca L. , Gauci J. , Edwards N. , Carachi E. , Mifsud M. , Piscopo T. 
Published: December 2014

Objective: Guidelines for swab use at our centre cover lower-limb wounds, ulcers and postoperative wound infections but not all types of wound. The objective of this study was to assess current practices in wound management at Mater Dei Hospital and to identify areas for improvement. Method: Wound swabs received at the microbiology department between February and April 2013 from adult inpatients departments were included. Wound swabs from the ophthalmology and paediatric departments were excluded. Patient comorbidities, detailed wound descriptions, acknowledgement of and documentation of culture and sensitivity results, and antibiotic changes during treatment were collected. Indictors of infection including white cell counts (WCCs) and C-reactive protein (CRP) were recorded. Results: The study included 134 patients. Diabetes mellitus (61.9%, n=83) was the most common underlying comorbidity. Postoperative wounds were the most common type of wounds swabbed (34.3%). The wound swab characteristics were not fully documented in 27 patients (20.1%). The CRP results were not recorded in 39.6% and WCCs were not taken in 10.4% of patients. Wound swab results were not acknowledged in the medical notes of 76% of cases. Conclusion: Wound swabs that were not indicated, lack of documentation and untimely acknowledgement of results were evident. This suggests that a significant proportion of wound swabs may not have been justified and had no impact on wound management. Our study clearly underlines the need for a more comprehensive guideline. Declaration of interest: There was no sponsorship of this study. The authors have no conflict of interest to declare.
Data Assimilation for Strongly Nonlinear Problems by Transformed Ensemble Kalman Filter
Authors: Liao Qinzhuo , Zhang Dongxiao 
Published: December 2014

Summary
The ensemble Kalman filter (EnKF) has been widely used for data assimilation. It is challenging, however, when the relation of state and observation is strongly nonlinear. For example, near the flooding front in an immiscible flow, directly updating the saturation by use of the EnKF may lead to nonphysical results. One possible solution, which may be referred to as the restarted EnKF (REnKF), is to update the static state (e.g., permeability and porosity) and rerun the forward model from the initial time to obtain the updated dynamic state (e.g., pressure and saturation). However, it may become time-consuming, especially when the number of assimilation steps is large.
In this study, we develop a transformed EnKF (TEnKF), in which the state is represented by displacement as an alternative variable. The displacement is first transformed from the forecasted state, then updated, and finally transformed back to obtain the updated state. Because the relation between displacement and observation is relatively linear, this new method provides a physically meaningful updated state without resolving the forward model. The TEnKF is tested in the history matching of multiphase flow in a 1D homogeneous medium, a 2D heterogeneous reservoir, and a 3D PUNQ-S3 model. The case studies show that the TEnKF produces physical results without the oscillation problem that occurs in the traditional EnKF, whereas the computational effort is reduced compared with the REnKF.
Impact of Antidepressant Therapy on Cognitive Aspects of Work, Condom Use, and Psychosocial Well-Being among HIV Clients in Uganda
Authors: Wagner Glenn J. , Ngo Victoria K. , Nakasujja Noeline , Akena Dickens , Aunon Frances , Musisi Seggane 
Published: December 2014

Objective: Depression has been found to impede several health outcomes among people living with HIV, but little research has examined whether depression treatment mitigates this influence. We assessed the impact of antidepressant therapy on measures of work, condom use, and psychosocial well-being among depressed HIV clients in Uganda. Methods: Paired t-tests and McNemar tests were used to assess change in survey data collected from participants at initiation of antidepressant therapy (baseline) and 6 months later. Results: Ninety-five participants completed the 6-month assessment, of whom 82 (86%) responded to treatment (defined as Patient Health Questionnaire-9 score < 5). Among study completers, work functioning improved significantly, as did measures of self-efficacy related to condom use and work (as well as general self-efficacy), and internalized HIV stigma declined; however, actual engagement in work activity and consistent condom use did not show significant change. Similar findings were observed among treatment responders. Conclusions: Antidepressant treatment benefits functional capacity, psychological well-being, and cognitive intermediary factors that may be essential for behavioral change related to work and condom use, but supplementary therapeutic strategies may be needed to impact more direct behavioral change.
Low Rate of Obesity among Psychiatric Inpatients in Indonesia
Authors: Marthoenis M. , Aichberger Marion , Puteh Ibrahim , Schouler-Ocak Meryam 
Published: December 2014

Objective: A vast majority of psychiatric medication causes weight gain, however the rate of obesity in psychiatric patients has yet to be thoroughly studied in Indonesia. The present study aims to assess the prevalence of obesity among psychiatric inpatients in Indonesia. Methods: This cross sectional study was conducted in Banda Aceh Psychiatric Hospital, Indonesia from December 2012 to January 2013. The Body Mass Index (BMI) and blood pressure of a total 242 inpatients was measured, and data on their demographic information and medication were collected from the patient's chart. Results: The prevalence rate of obesity among psychiatric inpatients was 5% (95% CI = 2.6–8.5%), and overweight was 8% (95% CI = 5.1–12.4). The mean BMI was 21.44 kg/m2 ( SD: 3.43). Stage I hypertension and stage II hypertension was found among 7% (95% CI = 4.1–11), and 2% (95% CI = 0.9–5.3%) inpatients, respectively. Conclusions: The findings suggest that the rate of overweight, obesity and hypertension in the present study population was relatively low compared to rates of the general population. The inpatients have limited access to food and only eat meals that are provided to them by the hospital.
Spirituality, Religion, and Health: Over the Last 15 Years of Field Research (1999–2013)
Authors: Lucchetti Giancarlo , Lucchetti Alessandra Lamas Granero 
Published: December 2014

Objective: Although several studies have examined the contribution of specific countries, journals, and authors in different scientific disciplines, little is known about the contribution of different world countries, journals, and authors to scientific research in the field of “Spirituality, religion, and health” (S/R). The present study aims to analyze the last 15 years of research in the field of spirituality and religiousness (S/R) through a bibliometric analysis. Methods: Using the Pubmed database, we retrieved all articles related to S/R field for the period 1999–2013. We then estimated the total number of publications, number of articles published per year, articles published per country, journals with most publications in S/R field, most productive authors, and most used keywords. Results: We found a growth of publications in the last years, most from the United States and the United Kingdom and published in the English language. Noteworthy, some developing countries such as India, Brazil, Israel, and Iran are at higher positions in this list. The S/R articles were published in journals embracing all fields of research, including high impact journals. Conclusion: In the present study, we took a closer look at the field of “Spirituality, religion, and health,” showing that this field of research has been constantly growing and consolidating in the scientific community.
Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test
Authors: Samardžić Janko , Puškaš Laslo , Obradović Miljana , Lazić-Puškaš Dijana 
Published: December 2014

Abstract
It has been shown in electrophysiological studies that the ligand L-655,708 possesses a binding selectivity and a moderate inverse agonist functional selectivity for α5-containing GABA-A receptors. The present study is aimed to investigate the antidepressant effects of the ligand L-655,708 in the forced swim test (FST) and its impact on locomotor activity in rats. The behavior of the animals was recorded with a digital camera, and the data were analyzed by one-way ANOVA, followed by Dunnett’s test. In FST, L-655,708 significantly decreased immobility time at a dose of 3 mg/kg after a single and repeated administration (p<0.05), exerting acute and chronic antidepressant effects. However, it did not induce significant differences in the time of struggling behavior during FST. Furthermore, L-655,708 did not show a significant effect on locomotor activity (p>0.05). These data suggest that negative modulation at GABA-A receptors containing the α5 subunit may produce antidepressant effects in rats. These effects were not confounded by locomotor influences.
Immuno-histomorphometric and -fluorescent characteristics of GH cells after treatment with genistein or daidzein in an animal model of andropause
Authors: Ajdžanović Vladimir , Medigović Ivana , Živanović Jasmina , Šošić-Jurjević Branka , Trifunović Svetlana , Tanić Nasta , Milošević Verica 
Published: December 2014

Abstract
Somatopause, the complex aspect of andropause, is recognizable by reduced growth hormone - GH/insulin-like growth factor 1 axis function in the ageing male. Soy isoflavones (usually genistein and daidzein), which are known for their beneficial effects in the treatment of ageing symptoms, are active in the pituitary, as well. The immunohistomorphometric and -fluorescent characteristics of pituitary growth hormone secreting cells, in an animal model of andropause, were examined after a treatment with genistein or daidzein. Andropausal Wistar rats were divided into sham operated, orchidectomized and genistein or daidzein treated orchidectomized groups. Genistein or daidzein (30 mg/kg/day) were administered subcutaneously for three weeks, while sham operated and orchidectomized groups received the vehicle alone. Growth hormone secreting cells were identified by the peroxidase-antiperoxidase immuno-histochemical, and immuno-fluorescent procedure. The main characteristic of growth hormone secreting cells in soy isoflavones treated groups is a weaker immuno-histochemical staining and immuno-fluorescent signal compared to sham operated and orchidectomized groups. The growth hormone secreting cell volume in orchidectomized +genistein or +daidzein groups is by 13.8% and 11.9% (p<0.05) smaller respectively, in comparison with the orchidectomized group. In orchidectomized +genistein or +daidzein groups, the growth hormone secreting cells relative volume density is by 62.5% and 61.0% lower (p<0.05) respectively than for the sham operated group, and decreased by 65.4% and 64.0% (p<0.05) respectively, compared to the orchidectomized group. It can be concluded that chronic genistein or daidzein treatment, in an animal model of andropause, attenuates immunohistomorphometric and -fluorescent characteristics of growth hormone secreting cells.
Influence of beta-glucan and vaccination against Lawsonia intracellularis on selected immune indices in weaned piglets
Authors: Kovačocyová Katarína , Reichel Peter , Seidel Herbert , Brenesselová Martina , Kósa Balász 
Published: December 2014

Abstract
The aim of this paper was to study the immunostimulating effects of feed additive containing beta-glucan given to pregnant sows and consecutive specific immunomodulation by vaccination of their suckling piglets. Thirty-five suckling piglets from the control and experimental group of sows were divided into four groups. Selected blood indices of immune profile (TIg, IMA, SI), specific antibodies against Lawsonia intracellularis formed in the blood serum of suckling piglets after vaccination, as well as production indices were observed. In all the groups, birth body weights were similar. After weaning, average daily weight gains were significantly higher (p < 0.05) in the group of vaccinated suckling piglets, as well as in suckling piglets from experimental sows. The same trend was recorded in average TIg values. Significant effects (p < 0.01) of beta-glucan and vaccination were observed in the changes of the index of metabolic activity of phagocytes (IMA) and less markedly in the index of stimulation activity of lymphocytes (SI). The least favorable results were observed in the group without both vaccination and beta-glucan. The effect of vaccination was manifested by ELISA estimation of specific antibodies (PI), when in both non-vaccinated groups (A and D) we observed minimum antibodies levels compared with vaccinated groups (B and C), which showed a high positivity without significant differences between the beta-glucan stimulated (C) and the non-stimulated group (B). These results suggest that beta-glucan given to sows and consecutive vaccination of suckling piglets can stimulate their non specific and specific immunity.
Evaluation of the effects of Salvia officinalis essential oil on plasma biochemistry, gut mucus and quantity of acidic and neutral mucins in the chicken gut
Authors: Čapkovičová Adriana , Maková Zuzana , Piešová Elena , Alves Anabela , Faix Štefan , Faixová Zita 
Published: December 2014

Abstract
In this study the effects of Salvia officinalis L. essential oil on the thickness of the gut mucus layer and quantity of neutral and acidic mucins in chickens were observed. Oneday-old chickens of Isa Brown breed were divided into five groups (n = 9) and fed 11 weeks as follows: control group (C): basal diet; experimental groups (E1 - E4) - same as C + sage essential oil (EO) in concentrations of 0.01%; 0.025%; 0.05% and 0.1%, respectively. The thickness of the mucus layer in the duodenum significantly increased in E3(0.05% sage EO) compared to E1 (0.01 % sage EO). In E3 (0.05% sage EO) the number of goblet cells containing acidic and neutral mucins was significantly decreased in the duodenum and jejunum and increased in the ileum compared to C. Feeding the diet supplemented with Se and 0.01% sage EO (E1) decreased plasma cholesterol level in comparison with E3(0.05 % sage EO). The addition of 0.05% (E3) and 0.1% sage EO (E4) to the diet caused a decrease in calcium plasma level compared to E2 (0.025 % sage EO). Plasma glucose level was significantly decreased in groups fed 0.05% (E3) and 0.025% sage EO (E2) compared with 0.01% sage (E1). The weight of internal organs was not affected by the diets. Our results suggest that effects of sage EO on the adherent mucus layer dynamics and mucin type distribution in the chicken intestine are dependent on sage EO dose and intestinal segment and there is still a need for further studies in order to obtain a plausible explanation.
The Investigation of DNA Damage Induced by Adrenaline in Human Lymphocytes in Vitro/Ispitivanja Oštećenja DNK Izazvanih Adrenalinom U Limfocitima Čoveka in Vitro
Authors: Milena Radaković , Ninoslav Đelić , Jevrosima Stevanović , Marko Anđelković , Stoimir Kolarević , Stefan Dačić , Zoran Stanimirović 
Published: December 2014

Abstract
Adrenaline is a neurotransmitter and hormone that plays an important role in physiological regulatory mechanisms. The objective of this study was to assess primary DNA damage in isolated human lymphocytes exposed to adrenaline using the in vitro comet assay. Dose-response of human lymphocytes was determined at concentration range of adrenaline from 0.01 μM to 300 μM for various treatment times (1h, 2h, 4h and 24h). The obtained results showed that adrenaline induced DNA damage at concentration range from 5 μM to 300 μM after 1h, 2h and 4h of treatment. The slightest DNA damage was observed after 24 h of adrenaline treatment - only the highest concentrations of adrenaline (150 μM and 300 μM) caused increased level of DNA damage. In order to evaluate the potential contribution of reactive oxygen species (ROS) in adrenaline-induced DNA damage we used antioxidants catalase (100 IU/mL and 500 IU/mL) and quercetin (100 μM and 500 μM). Co-treatment of lymphocytes with adrenaline (300 μM) and antioxidants for 1 h, significantly reduced the quantity of DNA in the comet tails. Therefore, it can be concluded that adrenaline exhibits genotoxic effects mainly through induction of reactive oxygen species and that some of the DNA damage is repaired during the first four hours following the treatment with adrenaline.
Creation Nerves of the Lumbar and Sacral Plexus in California Sea Lions (Zalophus Californianus) and Northern Elephant Seals (Mirounga Angustirostris)/Formiranje Nerava Iz Lumbalnog I Sakralnog Pleksusa Kod Kalifornijskog Morskog Lava (Zalophus Californianus) I Severnomorskog Slona (Mirounga Angustirostris)
Authors: Damir Mihelić , Hrvoje Smodlaka , Suzana Tkalčić , Lauren Palmer , Gordan Mršić , Katarina Špiranec , Daniel Špoljarić , Maja Popović , Draga Mihelić 
Published: December 2014

Abstract
The lumbosacral plexus was investigated in the California sea lion and Northern elephant seal. In 9 California sea lions and 2 Northern elephant seals the femoral nerve rises from the ventral branches of the 3rd and 4th lumbar nerves, whilst in one male and two specimens of the Northern elephant seal the 5th lumbar nerve was also involved. Ventral branches of the 3rd and 4th lumbar nerves comprised the obturatorius nerve in 7 specimens; in 3 specimens the 5th lumbar nerve additionally supplements the obturatorius nerve. In Northern elephant seals the obturatorius nerve originates from the ventral branches of the 3rd, 4th and 5th lumbar nerves. The ischiadic nerve originates from the ventral branches of the 4th, 5th lumbar and 1st sacral nerves in 8 specimens California sea lions and in 2 North elephant seals. In 2 specimens of both species the 2nd sacral nerve also participates. The gluteal nerve created ventral branches of the 5th lumbar and 1st sacral nerves in three specimens; however in one specimen the 4th and 5th lumbar nerves gave rise to the same nerve in the Northern elephant seal. In California sea lions the gluteal nerve originates from the ventral branches of the 5th lumbar nerve in seven specimens, nonetheless in 3 specimens the 4th lumbar nerve also participates in its formation.