bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-therapeutic laparotomies in military trauma (2009–2014)
Authors: Walker Patrick F. , Bozzay Joseph D. , Schechtman David W. , Shaikh Faraz , Stewart Laveta , Carson M. Leigh , Tribble David R. , Rodriguez Carlos J. , Bradley Matthew J. 
Published: August 2024

Abstract
Background
Combat casualties are frequently injured in austere settings where modern imaging modalities are unavailable. Exploratory laparotomies are often performed in these settings when there is suspicion for intra-abdominal injury. Prior studies of combat casualties reported non-therapeutic laparotomy (NTL) rates as high as 32%. Given improvements in combat casualty care over time, we evaluated NTLs performed during later years of the wars in Iraq and Afghanistan.

Methods
Military personnel with combat-related injuries (6/1/2009–12/31/2014) who underwent exploratory laparotomy based on concern for abdominal injury (i.e. not performed for proximal vascular control or fecal diversion) and were evacuated to Landstuhl Regional Medical Center (Germany) before being transferred to participating U.S. military hospitals were assessed. An NTL was defined as a negative laparotomy without substantial intra-abdominal injuries requiring repair. Characteristics, indications for laparotomy, operative findings, and outcomes were examined.

Results
Among 244 patients who underwent laparotomies, 41 (16.8%) had NTLs and 203 (83.2%) had therapeutic laparotomies (i.e. positive findings). Patients with NTLs had more computed tomography scans concerning for injury (48.8% vs 27.1%; p = 0.006), less penetrating injury mechanisms (43.9% vs 71.9%; p < 0.001), and lower Injury Severity Scores (26 vs 33; p = 0.003) compared to patients with therapeutic laparotomies. Patients with NTLs were also less likely to be admitted to the intensive care unit (70.7 vs 89.2% for patients with therapeutic laparotomies; p = 0.007). No patients with NTLs developed abdominal surgical site infections (SSI) compared to 16.7% of patients with therapeutic laparotomies (p = 0.002). There was no significant difference in mortality between the groups (p = 0.198).

Conclusions
Our proportion of NTLs was lower than reported from earlier years during the wars in Iraq and Afghanistan. No infectious complications from NTLs (i.e. abdominal SSIs) were identified. Nevertheless, surgeons should continue to have a low threshold for exploratory laparotomy in military patients in austere settings with concern for intra-abdominal injury.
Geschlechtsspezifische Langzeitergebnisse nach elektiver endovaskulärer Versorgung abdomineller Aortenaneurysmen bei Verwendung von Stentgrafts mit und ohne Fenestrierung oder Seitenarm
Authors: Annunziata Sonny Gennaro , Epple Jasmin , Schmitz-Rixen Thomas , Böckler Dittmar , Grundmann Reinhart T. 
Published: August 2024

Zusammenfassung
Ziel
Das geschlechtsspezifische Outcome nach endovaskulärer Versorgung (EVAR) eines intakten Bauchaortenaneurysmas in Abhängigkeit von der Wahl des Stentgrafts soll geprüft werden.

Methodik
Es wurde eine retrospektive Analyse von anonymisierten Daten des Wissenschaftlichen Instituts der AOK (WIdO) durchgeführt. Dabei wurden 15.699 Patienten (86,6 % Männer) zwischen dem 01.01.2010 und 31.12.2016 endovaskulär versorgt. Der Follow-up-Zeitraum endete am 31. Dezember 2018. Bei 12.922 (82,3 %) Patienten wurde eine aortobiiliakale Prothese ohne Fenestrierung oder Seitenarm (F/B), bei 881 (5,6 %) eine aortobiiliakale Prothese mit F/B, bei 1010 (6,4 %) eine aortomonoiliakale Prothese und bei 886 (5,6 %) eine Rohrprothese eingesetzt.

Ergebnisse
Die perioperative Letalität war bei Männern im Vergleich zu Frauen bei Patienten mit aortobiiliakaler Bifurkationsprothese ohne F/B signifikant geringer (2,2 % vs. 3,6 %; p < 0,001). Es bestand jedoch kein signifikanter Unterschied in der Klinikletalität zwischen Männern und Frauen in den anderen Vergleichsgruppen. Patienten mit aortomonoiliakaler Prothese wiesen mit 5,5 % eine signifikant höhere Klinikletalität auf als Patienten mit aortobiiliakaler Bifurkationsprothese ohne F/B (2,4 %; p < 0,001) und als Patienten mit Rohrprothese (3,3 %, p = 0,019). Das Langzeitüberleben der Männer war im Gesamtkrankengut signifikant besser als das der Frauen (46,9 % vs. 43,6 %; p = 0,002). Patienten mit aortobiiliakaler Bifurkationsprothese ohne F/B hatten nach 9 Jahren mit 47,7 % ein signifikant besseres Überleben als Patienten mit Bifurkationsprothese und F/B (45,6 %; p < 0,001) und als Patienten mit aortomonoiliakaler Prothese (36,4 %, p < 0,001) oder solche mit einer Rohrprothese (42,1 %, p < 0,001).

Schlussfolgerung
Frauen hatten im Vergleich zu Männern ein signifikant ungünstigeres perioperatives Outcome. Das Geschlecht war aber risikoadaptiert kein Risikofaktor für das Langzeitüberleben. Langfristig wiesen Patienten mit aortobiiliakalen Prothesen ohne F/B ein günstigeres Überleben auf als Patienten mit fenestrierten/gebranchten Prothesen. Die ungünstigsten Ergebnisse wurden mit aortomonoiliakalen Prothesen erzielt.
Transanal circumferential pouch advancement for treatment of pouch vaginal fistulae
Authors: Obi M. , Klingler M. , Sapci I. , Lavryk O. , Lipman J. , Steele S. R. , Hull T. , Holubar S. D. 
Published: August 2024

Abstract
Background
Ileal pouch anal anastomosis (IPAA) circumferential pouch advancement (CPA) involves full-thickness transanal 180–360° dissection of the distal pouch, allowing the advancement of healthy bowel to cover the internal opening of a vaginal fistula. We aimed to describe the long-term outcomes of this rare procedure.

Methods
Patients with IPAA who underwent transanal pouch advancement for any indication between 2009 and 2021 were included. Demographics, operative details, and outcomes were reviewed. An early fistula was defined as occurring within 1 year of IPAA construction. Clinical success was defined as resolution of symptoms necessitating CPA, pouch retention, and no stoma at the time of follow-up. Figures represent the median (interquartile range) or frequency (%).

Results
Over a 12-year period, nine patients were identified; the median age at CPA was 41 (36–44) years. Four patients developed early fistula after index IPAA, and five developed late fistulae. The median number of fistula repair procedures prior to CPA was 2 (1–2). All patients were diagnosed with ulcerative colitis at the time of IPAA and all late patients were re-diagnosed with Crohn’s disease. Four (44.4%) patients had ileostomies present at the time of surgery, three (33.3%) had one constructed during surgery, and two (22.2%) never had a stoma. The median follow-up time was 11 (6–24) months. Clinical success was achieved in four of the nine (44.4%) patients at the time of the last follow-up.

Conclusions
Transanal circumferential pouch advancement was an effective treatment for refractory pouch vaginal fistulas and may be offered to patients who have had previous attempts at repair.
Novel method for detecting frequent TERT promoter hot spot mutations in bladder cancer samples
Authors: Kovács Ákos , Sükösd Farkas , Kuthi Levente , Boros Imre M. , Vedelek Balázs 
Published: August 2024

AbstractTelomerase reverse transcriptase promoter (TERTp) mutations are frequently targeted tumor markers, however, they reside in regions with high GC content, which poses challenges when examined with simple molecular techniques or even with next-generation sequencing (NGS). In bladder cancer (BC), TERTp mutations are particularly frequent, however, none of the available tools have demonstrated efficacy in detecting TERTp mutations via a simple noninvasive technique. Therefore, we developed a novel PCR-based method for the detection of the two most common TERTp mutations and demonstrated its use for the analysis of BC samples. The developed SHARD-PCR TERTp mutation detection technique requires PCR and restriction digestion steps that are easily implementable even in less well-equipped laboratories. Cell lines with known mutational status were utilized for method development. Matching urine and tumor tissue samples from BC patients were analyzed, and the results were validated by next-generation sequencing. Analysis of eighteen urine and corresponding tumor tissue samples by SHARD-PCR revealed perfect matches in sample pairs, which paralleled the corresponding NGS results: fourteen samples exhibited mutations at the −124 position, two samples showed mutations at the −146 position, and no mutations were detected in two samples. Our study serves as a proof-of-concept and is limited by its small sample size, nonetheless, it demonstrates that SHARD-PCR is a simple, economic and highly reliable method for detecting TERTp mutations, which are common in different cancer types. For bladder cancer, SHARD-PCR can be performed with the use of noninvasive samples and could replace or complement currently used techniques.
Environmental challenge of vehicle dispatching in marine container drayage
Authors: Nishimura Etsuko , Papadimitriou Stratos , Shintani Koichi , Imai Akio 
Published: August 2024

AbstractIn marine container drayage (CD), which refers to the transport of goods over a short distance, empty containers (ECs) are required to be transported long distances between a terminal and a shipper/consignee by conventional transportation. This causes truck traffic congestion in harbor districts that increases CO2 emissions (CO2EM). This study addresses the vehicle dispatch problem with respect to the environmental impact of marine CD, considering the tractor dwell time is long at the customer site due to cumbersome container loading/unloading (L/U). We model this problem as an extended version of the vehicle routing problem with precedence constraints to minimize the total CO2 weighted travel distance. To improve CD operation in long L/U time, we propose a new practice for CD operations. Additionally, we develop a mixed integer programing model (MIP) for the new practice representation, and propose a Simulated Annealing (SA) based heuristic approach to solving the new practice instance. By implementing our proposed new operation, in a long L/U time, the CO2EM, EC move and number of tractors required can also be reduced by allowing uncoupled tractor move.
Injectable and printable nanocellulose-crosslinked quaternary chitosan blends for potential wound healing
Authors: Madani Maryam , Laurén Isabella , Borandeh Sedigheh , Gounani Zahra , Laaksonen Timo , Lindfors Nina , Seppälä Jukka 
Published: August 2024

AbstractDeveloping hydrogels with excellent 3D printability, injectability, and mechanical integrity presents an imposing challenge in biomaterials research, especially in the biomedical field where biocompatibility is crucial. This study involved the development of 3D printable and injectable polysaccharide-based hydrogels with inherent self-healing capabilities. Carboxymethyl chitosan and quaternized chitosan (QCS) functioned as polymer backbones, reinforced by dialdehyde-cellulose nanocrystals (DACNC) as a cross-linker. Here, the concentrations of QCS and DACNC were adjusted and optimized for ideal performance. The cross-linking process was orchestrated in situ, integrating dynamic hydrogen bonds and Schiff base covalent bonds to achieve a multi-cross-linked hydrogel network. Comprehensive characterization of the material, including rheological measurements and macroscopic evaluations, demonstrated the hydrogel’s admirable injectability, printability, and self-healing attributes. In vitro cell viability assessments on human dermal fibroblasts revealed favorable biocompatibility and minimal cytotoxicity of the hydrogels, properties influenced by the concentrations of QCS. The obtained hydrogels exhibit promising attributes suitable for fabricating 3D printable and injectable hydrogel customized for biomedical applications, particularly wound healing.
Graphical abstract
Process Quality in Early Childhood Education and Care in Australia: A Systematic Literature Review
Authors: Ha Nguyen Thi Ngoc , Tham Melissa , Hurley Peter 
Published: August 2024

AbstractThis review examines the extant Australian literature on process quality in ECEC, which is understood as children’s actual experience within a childcare setting such as interactions between educators and children. A thematic analysis of empirical evidence from the 21 qualified articles reveals key characteristics of ECEC process quality studies, the benefits of process quality to child outcomes, and some factors influencing process quality. The review highlights the increasing interest in ECEC process quality in Australia and that process quality can be linked to children’s outcomes in the early years. It also underscores that outdoor environments and educators’ attributes such as personal experiences and qualifications stood out as the key supporting factors of process quality. More importantly, the review found that most of the process quality studies in Australia were conducted in metropolitan areas, and there were only two studies focused on children from disadvantaged backgrounds. The paper calls for more actions to combine process quality with equity across types of ECEC services.
Quantum Physics, Digital Computers, and Life from a Holistic Perspective
Authors: Ellis George F. R. 
Published: August 2024

AbstractQuantum physics is a linear theory, so it is somewhat puzzling that it can underlie very complex systems such as digital computers and life. This paper investigates how this is possible. Physically, such complex systems are necessarily modular hierarchical structures, with a number of key features. Firstly, they cannot be described by a single wave function: only local wave functions can exist, rather than a single wave function for a living cell, a cat, or a brain. Secondly, the quantum to classical transition is characterised by contextual wave-function collapse shaped by macroscopic elements that can be described classically. Thirdly, downward causation occurs in the physical hierarchy in two key ways: by the downward influence of time dependent constraints, and by creation, modification, or deletion of lower level elements. Fourthly, there are also logical modular hierarchical structures supported by the physical ones, such as algorithms and computer programs, They are able to support arbitrary logical operations, which can influence physical outcomes as in computer aided design and 3-d printing. Finally, complex systems are necessarily open systems, with heat baths playing a key role in their dynamics and providing local arrows of time that agree with the cosmological direction of time that is established by the evolution of the universe.
The Mystery of Black Rice: Food, Medicinal, and Spiritual Uses of Oryza glaberrima by Maroon Communities in Suriname and French Guiana
Authors: Pinas Nicholaas M. , Jackson John , Mosis Noeki André , van Andel Tinde 
Published: August 2024

AbstractDuring plantation slavery, African rice (Oryza glaberrima Steud.) was widely cultivated in the Americas but was soon replaced by Asian rice (Oryza sativa L.). Maroons, descendants of Africans who escaped slavery in Suriname and French Guiana, continue to cultivate African rice. Genomic research linked this rice to an O. glaberrima variety in the Ivory Coast. Based on interviews with 99 Maroon farmers, of whom 23 cultivate black rice, we describe its diverse uses as (ceremonial) food, offerings, spiritual medicine, and its role during funerals. Maroon oral history accounts on the origin of black rice differ among and within communities: enslaved women brought it from Africa or took it from the plantations where they worked; escaped slaves found it in the savanna; or ancestors encountered it in interior swamps. These multiple and sometimes contradictory accounts of the origins of black rice are related to the diverse ethnic and geographical backgrounds of the Africans brought as slaves to Suriname and their different histories with the crop after marronage. Various characteristics of black rice, including its ability to compete with weeds and grow on poor soils, its shattering seeds, and its visibility to birds explain how this African domesticate survived in the wild in the Amazonian forest. The migration of Maroons to cities, their engagement in gold mining, and their evangelization may lead to the loss of black rice knowledge and practices.
Abiotic triggers for maximising germling numbers in Asparagopsis taxiformis (Rhodophyta, Bonnemaisoniales) via tetrasporogenesis
Authors: Theobald Emma J. , Rule Margaret B. , Jackson Timothy L. , Rula Najeen A. , Diaz-Pulido Guillermo , Jackson Emma L. 
Published: August 2024

AbstractThere is global interest in cultivating the red alga Asparagopsis taxiformis due to its efficacy as a potent anti-methanogenic feed supplement and as a biofilter for the bioremediation of nutrient-enriched waters. However, the development of A. taxiformis cultivation is currently hindered by a lack of information about the conditions required to maximise tetraspore release and thus secure a reliable source of germlings for out-planting. In this study, we examined the effects of temperature, irradiance, and standard nutrient supplementation (F/8, potassium iodide (KI) and arsenic trioxide (As2O3)) on the number of germlings produced per tetrasporophyte, using a strain of A. taxiformis widespread within the Great Barrier Reef, Australia. Temperature, irradiance and nutrient supplementation played a pivotal role in germling numbers, which was optimised at 22 °C under 7 µmol photons m−2 s−1 and with supplementation of F/8 nutrient media, arsenic trioxide (As2O3; 98 µg L−1) and potassium iodide (KI; 166 µg L−1). Once tetrasporophytes were removed from these inducing conditions, tetrasporogenesis ceased within 12 days. In a further five-week experiment investigating the effect of separate supplementation of As2O3 and KI, germling numbers were maximised under supplementation with either As2O3 or As2O3 + KI, with the relative growth rate of tetrasporophytes maximised under supplementation with F/8 + As2O3 + KI. Under optimum conditions, an average of 3,261 ± 826 (SD) germlings were produced per tetrasporophyte over a five-week period. Our results provide a strong starting point for developing hatchery protocols for generating a reliable supply of germlings for nursery cultivation in tropical settings.
Patient experience of social and medical fertility preservation fully reimbursed in France
Authors: Hagege Estelle , Pirtea Paul , Burette Julie , Canepa Anne-Sophie , Graesslin Olivier , de Ziegler Dominique 
Published: August 2024

Abstract
Purpose
The purpose of this study is to review patient experience with social fertility preservation (sFP), as compared to medical fertility preservation (mFP), in a context where sFP is fully reimbursed.

Methods
We conducted a retrospective cohort study involving patients who underwent oocyte cryopreservation for mFP between 2017 and 2023 and sFP between 2022 and 2023 at a large ART single center. Additionally, we surveyed patients undergoing sFP and mFP, regarding their experiences, intentions, awareness, and financial consideration.

Results
A total of 97 oocyte retrievals were performed for sFP in 75 women, and 155 were performed in mFP (127 women). Median ages were 36.4 years for sFP and 28.9 years for mFP. Median oocytes retrieved per session were 10 for sFP and 8 for mFP. Ninety-seven percent of of mFP participants were informed by healthcare professionals, while half of sFP participants learned through personal acquaintances. The primary motivation for sFP was a desire for pregnancy while being single. Most respondents in both groups knew that 15–20 oocytes are typically needed for a successful birth. None were aware of the “DuoStim” option, but interest was expressed by most women. Surprisingly, despite full reimbursement for sFP in France, 78% expressed willingness to pay if necessary.

Conclusion
Many women choose sFP due to concerns about declining fertility, often informed by non-medical sources. Free access to sFP can help mitigate the global decline in natality by allowing women to anticipate age-related fertility decline. This study should be considered by other countries as they may increasingly cover sFP costs in the future.
Towards a Scalable Proof Engine: A Performant Prototype Rewriting Primitive for Coq
Authors: Gross Jason , Erbsen Andres , Philipoom Jade , Agrawal Rajashree , Chlipala Adam 
Published: August 2024

AbstractWe address the challenges of scaling verification efforts to match the increasing complexity and size of systems. We propose a research agenda aimed at building a performant proof engine by studying the asymptotic performance of proof engines and redesigning their building blocks. As a case study, we explore equational rewriting and introduce a novel prototype proof engine building block for rewriting in Coq, utilizing proof by reflection for enhanced performance. Our prototype implementation can significantly improve the development of verified compilers, as demonstrated in a case study with the Fiat Cryptography toolchain. The resulting extracted command-line compiler is about 1000$$\times $$
×
faster while featuring simpler compiler-specific proofs. This work lays some foundation for scaling verification efforts and contributes to the broader goal of developing a proof engine with good asymptotic performance, ultimately aimed at enabling the verification of larger and more complex systems.
Ensemble modeling of extreme seasonal temperature trends in Iran under socio-economic scenarios
Authors: Kamangar Muhammad , Ahmadi Mahmud , Rabiei-Dastjerdi Hamidreza , Hazbavi Zeinab 
Published: August 2024

Abstract
In climate science, ensemble modeling has emerged as a powerful tool for addressing the uncertainties inherent in individual climate models. This approach generates more robust and reliable predictions by harnessing the collective insights of multiple models. Nonetheless, the method of combining these models to derive an ensemble model remains an open question. To this end, the objectives of this research are twofold: (i) to introduce and evaluate the weighted average-correlation ensemble model for projecting minimum and maximum temperatures in Iran, and (ii) to assess near-term (2021–2040) trends across 95 synoptic stations using socio-economic scenarios derived from five models: GFDL-ESM4, MPI-ESM1-2-HR, IPSL-CM6A-LR, MRI-ESM2, and UKESM1-0-LL. The ensemble technique effectively reduces the Root Mean Square Error (RMSE) (1/3 − 1/10) associated with the individual models. The predicted values for the minimum temperature are more similar to the actual data than the maximum temperature. The results also indicate a significant increase in the minimum temperature compared to the maximum temperature during the base period. The distribution of the maximum temperature across the country is influenced mainly by its latitude. In contrast, the distribution of the minimum temperature is influenced by both the country’s major altitudes and latitudes. Surveys also indicate that, compared to the base period, there is an increasing trend in temperature for winter, spring, and autumn, while a decrease is observed during the summer. Notably, the increase in temperature is more pronounced during winter.