bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant, total phenolic contents and antinociceptive potential of Teucrium stocksianum methanolic extract in different animal models
Authors: Shah Syed Muhammad Mukarram , Sadiq Abdul , Shah Syed Muhammad Hassan , Ullah Farhat 
Published: June 2014

Abstract

Background
Oxidative stress and analgesia are connected with different pathological conditions. The drug candidates from synthetic sources are associated with various side effects; therefore, researchers are giving priority to find novel, effective and safe phytomedicines. Teucrium species possesses antioxidant, analgesic, anti-inflammatory and hepatoprotective activities. The essential oils of Teucrium stocksianum have shown strong antinociceptive potential. Our current study is designed to embark total phenolic content (TPC), antioxidant and antinociceptive potential of the methanolic extract of Teucrium stocksianum (METS).

Method
Phytochemical composition was determined by using standard methods. Free radical scavenging potential and TPC of METS were assessed by using 2, 2-diphenyl-1-picryl-hydrazyl (DPPH) and Folin-Ciocalteu Reagent (FCR) respectively. Antinociceptive potential was determined by acetic acid induced abdominal writhing, formalin induced paw licking and tail immersion tests. Different test dose 50, 100 and 150 mg/kg body weight of METS were administered intra peritonealy (i.p) to various groups of mice for the evaluation of analgesic potential.

Results
Phytochemical screening confirmed the presence of flavonoids, tannins, saponins, anthraquinone, steroid, phlobatannin, terpenoid, glycoside and reducing sugars. METS was found safe at a dose of 1000 mg/kg body weight. A concentration dependent free radical scavenging effect was observed with methanolic aerial parts extract of Teucrium stocksianum (MAPETS) and methanolic roots extracts of Teucrium stocksianum (MRETS). MAPETS and MRETS have shown highest antioxidant activity 91.72% and 86.19% respectively at 100 μg/ml. MAPETS was found more rich (115.32 mg of GAE/g of dry material) in TPC as compared to MAPETS (105.41 mg of GAE/g). METS demonstrated a dose dependent antinociceptive potential in different pain models, like in acetic acid, formalin and tail immersion showing 83.103%, 80.872% and 67.58% at a dose of 150 mg/kg, similar to acetylsalicylic acid (74.79%, 82.87%, 100 mg/kg) and TramadolR (74%, 30 mg/kg) respectively.

Conclusion
Strong antioxidant potential and high TPCs are residing in the methanolic extract of T. stocksianum. METS showed analgesic potential in all models of nociception implying that both peripheral and central pathways of analgesia are involved. This might be due to the presence of various classes of phytochemicals in the plant extract.
Prevalence and correlates of unhealthy weight control behaviors: findings from the national longitudinal study of adolescent health
Authors: Stephen Eric M , Rose Jennifer S , Kenney Lindsay , Rosselli-Navarra Francine , Weissman Ruth Striegel 
Published: June 2014

AbstractBackgroundA recent study examined the prevalence, clinical correlates, age trends, and stability of unhealthy weight control behaviors (UWCB; purging and diet pill use) in a nationally representative sample of Norwegian boys and girls. The purpose of this study was to provide similar, comparative analyses for a nationally representative sample of American youth.MethodsData were extracted from the restricted use data files of survey Waves I, II, and III of the National Longitudinal Study of Adolescent Health (Add Health), selecting all participants who at Wave I had provided information on age, sex, and UWCB. Using UWCB information, three groups were created (purging, diet pill use, and no recent UWCB “controls”) and compared on indicators of adverse health or mental health.ResultsGirls consistently were more likely than boys to report UWCB. UWCB were significantly associated with higher body mass index, self-perception of being overweight, low self-esteem, depression, and delinquency. Prevalence estimates for purging remained relatively constant across the three survey waves; in contrast, diet pill use was especially common at Wave III.ConclusionsAge trends, gender differences, and clinical correlates of change in the likelihood of UWCB between Waves I-III were all identified in analyses comparing purging and diet pill use in American adolescents. Females and older adolescents were specifically more likely to engage in pill use than purging, and individuals with increased weight dissatisfaction, a history of delinquent behaviors, more depression symptoms, or lower self-esteem were more likely to engage in an unhealthy weight control behavior over time. While the Norwegian study found that prevalence of purging was lower among young adult participants, our results suggested that there were no significant differences in prevalence between age groups.
Mortality Risk for Women on Chronic Hemodialysis Differs by Age
Authors: Sood Manish M , Rigatto Claudio , Komenda Paul , Mojica Julie , Tangri Navdeep 
Published: June 2014

Background: Previous reports have demonstrated similar survival for men and women on hemodialysis, despite women's increased survival in the general population. Objectives: To examine the effect of age on mortality in women undergoing chronic hemodialysis. Design: A retrospective cohort study using an administrative data registry, the Canadian Organ Replacement Registry (CORR) from Jan. 2001 and Dec. 2009. Setting: Canada. Patients: 28,971 (Women 11,792 (40.7%), Men 17,179 (59.3%)) incident chronic hemodialysis patients who survived greater than 90 days on dialysis. Measurements: All-cause mortality. Methods: Cox proportional hazards and competing risks models were employed to determine the independent association between sex, age and likelihood of all-cause mortality with renal transplantation as the competing outcome. Results: During the study period, 6060 (51.4%) of women and 8650 (50.4%) of men initiating dialysis died. Younger women experienced higher mortality (Age < 45: Women 22.5%, Men 18.2%, hazard ratio (HR) 1.31 (1.12–1.52)) whereas elderly women experience lower mortality (Age 75–85: Women 65%, Men 67.3%, HR 0.94 95% CI 0.88–0.99, Age > 85: Women 66%, Men 70.2%, HR 0.83 95% CI 0.71–0.97) compared to men. This relationship persisted after accounting for the competing risk of transplantation. Limitations: The cause of death was unknown. Conclusions: Women's survival on chronic hemodialysis varies by age compared to men with a significantly higher mortality in women younger than 45 years old and lower mortality in woman older than 75 years of age.
On simulations of spinning processes with a stationary one-dimensional upper convected Maxwell model
Authors: Lorenz Maike , Marheineke Nicole , Wegener Raimund 
Published: June 2014

Abstract
This work deals with the behavior of viscoelastic jets under gravitational forces described by an asymptotic upper convected Maxwell (UCM) model, system of partial differential equations. Considering fiber spinning, we show that the one-dimensional model equations in general allow for the simulation of drawing processes with and without die swell effect. But, as the model is of hyperbolic type and the run of the characteristics crucially depend on the physical parameters, the existence regimes of the stationary solutions associated to certain boundary conditions turn out to be limited. We investigate the regimes for gravitational uniaxial and 2d spinning scenarios numerically.
Intrinsic multipotential mesenchymal stromal cell activity in gelatinous Heberden’s nodes in osteoarthritis at clinical presentation
Authors: Baboolal Thomas G , Boxall Sally A , Churchman Sarah M , Buckley Conor T , Jones Elena , McGonagle Dennis 
Published: June 2014

Abstract
Introduction
Gelatinous Heberden’s nodes (HNs), also termed synovial cysts, are a common form of generalized osteoarthritis (OA). We sought to determine whether HN cases at clinical presentation contained multipotential stromal cells (MSCs) and to explore whether such cells were more closely related to bone marrow (BM) or synovial fluid (SF) MSCs by transcriptional analysis.

Methods
At clinical presentation, gelatinous material was extracted/extruded from the distal phalangeal joint of OA patients with HNs. From this, plastic adherent cells were culture-expanded for phenotypic and functional characterization and comparison with BM- and SF-MSCs. Mesenchymal related gene expression was studied by using a custom-designed TaqMan Low Density Array to determine transcriptional similarities between different MSC groups and skin fibroblasts.

Results
In all cases, HN material produced MSC-like colonies. Adherent cultures displayed an MSC phenotype (CD29+, CD44+, CD73+, CD81+, and CD90+ and CD14- CD19-, CD31-, CD34-, CD45-, and HLADR-) and exhibited osteogenic, chondrogenic lineage differentiation but weak adipogenesis. Gene cluster analysis showed that HN-MSCs were more closely related to SF- than normal or OA BM-MSCs with significantly higher expression of synovium-related gene markers such as bone morphogenic protein 4 (BMP4), bone morphogenetic protein receptor type 1A (BMPR1A), protein/leucine-rich end leucine-rich repeat protein (PRELP), secreted frizzled-related protein 4 (SFRP4), and tumor necrosis factor alpha-induced protein 6 (TNFAIP6) (P <0.05).

Conclusions
Gelatinous HNs derived from hand OA at clinical presentation contain a population of MSCs that share transcriptional similarities with SF-derived MSCs. Their aberrant entrapment within the synovial cysts may impact on their normal role in joint homeostasis.
It’s not just the antibiotics, it’s the treatment
Authors: Guidry Christopher A , Sawyer Robert G 
Published: June 2014

AbstractThe recent study by Bloos and colleagues demonstrates that early initiation of antimicrobial therapy is not associated with improved survival in sepsis. We contend that these findings should not be surprising. This study is yet another part of the growing case against early and aggressive antimicrobial therapy and highlights the important roles resuscitation and source control play in the management of the septic patient. We suggest that, whenever possible, antimicrobial therapy should we withheld until objective evidence of infection has been obtained.
Antigen-Specific Immune Responses and Clinical Outcome After Vaccination With Glioma-Associated Antigen Peptides and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Children With Newly Diagnosed Malignant Brainstem and Nonbrainstem Gliomas
Authors: Pollack Ian F. , Jakacki Regina I. , Butterfield Lisa H. , Hamilton Ronald L. , Panigrahy Ashok , Potter Douglas M. , Connelly Angela K. , Dibridge Sharon A. , Whiteside Theresa L. , Okada Hideho 
Published: June 2014

PurposeDiffuse brainstem gliomas (BSGs) and other high-grade gliomas (HGGs) of childhood carry a dismal prognosis despite current treatments, and new therapies are needed. Having identified a series of glioma-associated antigens (GAAs) commonly overexpressed in pediatric gliomas, we initiated a pilot study of subcutaneous vaccinations with GAA epitope peptides in HLA-A2–positive children with newly diagnosed BSG and HGG.Patients and MethodsGAAs were EphA2, interleukin-13 receptor alpha 2 (IL-13Rα2), and survivin, and their peptide epitopes were emulsified in Montanide-ISA-51 and given every 3 weeks with intramuscular polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose for eight courses, followed by booster vaccinations every 6 weeks. Primary end points were safety and T-cell responses against vaccine-targeted GAA epitopes. Treatment response was evaluated clinically and by magnetic resonance imaging.ResultsTwenty-six children were enrolled, 14 with newly diagnosed BSG treated with irradiation and 12 with newly diagnosed BSG or HGG treated with irradiation and concurrent chemotherapy. No dose-limiting non-CNS toxicity was encountered. Five children had symptomatic pseudoprogression, which responded to dexamethasone and was associated with prolonged survival. Only two patients had progressive disease during the first two vaccine courses; 19 had stable disease, two had partial responses, one had a minor response, and two had prolonged disease-free status after surgery. Enzyme-linked immunosorbent spot analysis in 21 children showed positive anti-GAA immune responses in 13: to IL-13Rα2 in 10, EphA2 in 11, and survivin in three.ConclusionGAA peptide vaccination in children with gliomas is generally well tolerated and has preliminary evidence of immunologic and clinical responses. Careful monitoring and management of pseudoprogression is essential.
Cancer-Specific Outcomes Among Young Adults Without Health Insurance
Authors: Aizer Ayal A. , Falit Benjamin , Mendu Mallika L. , Chen Ming-Hui , Choueiri Toni K. , Hoffman Karen E. , Hu Jim C. , Martin Neil E. , Trinh Quoc-Dien , Alexander Brian M. , Nguyen Paul L. 
Published: June 2014

Purpose The Patient Protection and Affordable Care Act (ACA) will likely improve insurance coverage for most young adults, but subsets of young adults in the United States will face significant premium increases in the individual market. We examined the association between insurance status and cancer-specific outcomes among young adults. Methods We used the SEER program to identify 39,447 patients age 20 to 40 years diagnosed with a malignant neoplasm between 2007 and 2009. The association between insurance status and stage at presentation, employment of definitive therapy, and all-cause mortality was assessed using multivariable logistic or Cox regression, as appropriate. Results Patients who were uninsured were more likely to be younger, male, nonwhite, and unmarried than patients who were insured and were also more likely to be from regions of lower income, education, and population density (P < .001 in all cases). After adjustment for pertinent confounding variables, an association between insurance coverage and decreased likelihood of presentation with metastatic disease (odds ratio [OR], 0.84; 95% CI, 0.75 to 0.94; P = .003), increased receipt of definitive treatment (OR, 1.95; 95% CI, 1.52 to 2.50; P < .001), and decreased death resulting from any cause (hazard ratio, 0.77; 95% CI, 0.65 to 0.91; P = .002) was noted. Conclusion The improved coverage fostered by the ACA may translate into better outcomes among most young adults with cancer. Extra consideration will need to be given to ensure that patients who will face premium increases in the individual market can obtain insurance coverage under the ACA.
Kinetically Controllable Supramolecular Polymerization through Synchronized Activation of Monomers
Authors: Numata Munenori , Sakai Ryo-ichiro 
Published: June 2014

Abstract
The morphologies and functionalities of supramolecular architectures are governed entirely by the molecular design and the self-assembling field. Herein, we demonstrate that use of a microflow system to precisely regulate the self-assembling field enables control over the pathway for self-assembly of a designed molecule. By changing the flow rate, we could selectively create supramolecular nanofibers having various length and stabilities under nonequilibrium conditions.
„Die größte Seltenheit darin ist gewiss der Bibliothekar …“ – Zum Wandel in einer kleinen Regionalbibliothek
Authors: Riethmüller Marianne 
Published: June 2014

Zusammenfassung:
Vor über 13 Jahren wurde die bis dato selbstständige Hessische Landesbibliothek Fulda per Vermerk im Haushaltsgesetz des Landes Hessen für das Jahr 2001 in die Fachhochschule Fulda eingegliedert. Bei der ersten darauf folgenden Tagung der AG Regionalbibliotheken war die Skepsis der Kolleginnen und Kollegen in Bezug auf die gerade erst erfolgte Fusion deutlich zu spüren. Mehr als ein Jahrzehnt ist ins Land gegangen und es stellt sich die Frage, was aus der fusionierten Bibliothek geworden ist – ist das Ergebnis gut, ist das Ergebnis schlecht? Oder, um in der Fragestellung des Sonderbandes zu bleiben, hat die Bibliothek mit der Integration tatsächlich einen Strukturwandel vollzogen?
Die Wissenschaftliche Stadtbibliothek Mainz: Neuausrichtung in Reaktion auf nachhaltige Sparmaßnahmen – gezielte Umstrukturierung statt Abwicklung
Authors: Fliedner Stephan 
Published: June 2014

Zusammenfassung:
Die Wissenschaftliche Stadtbibliothek Mainz, eine der größten wissenschaftlichen Kommunalbibliotheken, war 2011 aufgrund von Sparmaßnahmen des Trägers von Zerschlagung und Abwicklung bedroht. Zähe Verhandlungen, aber auch das mutige und konstruktive Auftreten der Mitarbeiter und eine bemerkenswerte Petition des Fördervereins konnten die Schließung abwenden.
Die sich daran anschließenden radikalen Etatkürzungen erfordern allerdings ebenso radikale Umstrukturierungsmaßnahmen. Dabei steht das Konzept einer Wissenschaftlichen Regional- und Forschungsbibliothek mit den beiden Schwerpunkten „Regionalbibliothek für Mainz und Rheinhessen“ sowie „Forschungsbibliothek für Buch- und Kulturwissenschaften“ im Mittelpunkt.
Die Memoria der Bibliothek: Perspektiven der Staats- und Stadtbibliothek Augsburg nach der Verstaatlichung
Authors: Laube Reinhard 
Published: June 2014

Zusammenfassung:
Bibliothek ist Gedächtnis, Bibliothek perspektiviert Gedächtnis und Bibliothek formiert Gedächtnis: So lauten die bibliothekspolitischen Axiome, mit denen die Kultureinrichtung Bibliothek Zeugnis ablegt von der Macht der Memoria. Im Fall der Staats- und Stadtbibliothek Augsburg wurden Macht und Grenzen der institutionellen Memoria sichtbar durch ihre Infragestellung. Im Jahr 2010 wurde nicht nur offen über die Auflösung der Sammlung gesprochen, sondern zugleich auch über die Bedeutung der Einrichtung, die durch Vergewisserung der Memoria bekräftigt wurde. Der Fortbestand der Bibliothek und die Integrität der Sammlung konnten 2012 durch Einbindung in das System der regionalen Staatlichen Bibliotheken gesichert werden. Die Zukunft der regional orientierten Forschungsbibliothek liegt in der Zukunft der Memoria, entfaltet durch verschiedene Strategien des Bestandsmanagements, der Erschließung, der Öffentlichkeitsarbeit und des Bibliotheksbaus.
Die Staatliche Bibliothek Regensburg: eine Regionalbibliothek im Strukturwandel
Authors: Lübbers Bernhard 
Published: June 2014

Zusammenfassung:
Der Beitrag hebt darauf ab, dass für Regionalbibliotheken neben der digitalen Bereitstellung der Bestände auch die wissenschaftliche Komponente nicht vernachlässigt werden darf.
The Coexistence of Terms to Describe the Presence of Multiple Concurrent Diseases
Authors: Almirall José , Fortin Martin 
Published: June 2014

Background Consensus on terminology for multiple diseases is lacking. Because of the clinical relevance and social impact of multiple concurrent diseases, it is important that concepts are clear. Objective To highlight the diversity of terms in the literature referring to the presence of multiple concurrent diseases/conditions and make recommendations. Design A bibliometric analysis of English-language publications indexed in the MEDLINE database from 1970 to 2012 for the terms comorbidity, multimorbidity, polymorbidity, polypathology, pluripathology, multipathology, and multicondition, and a review of definitions of multimorbidity found in English-language publications indexed from 1970 to 2012 in the MEDLINE and SCOPUS databases. Results Comorbidity was used in 67,557 publications, multimorbidity in 434, and the other terms in three to 31 publications. At least 144 publications used the term comorbidity without referring to an index disease. Thirteen general definitions of multimorbidity were identified, but only two were frequently used (91% of publications). The most frequently used definition (48% of publications) was “ more than one or multiple chronic or long-term diseases/conditions”. Multimorbidity was not defined in 51% of the publications using the term. Conclusions Comorbidity was overwhelmingly used to describe any clinical entity coexisting with an index disease under study. Multimorbidity was the term most frequently used when no index disease was designated. Several definitions of multimorbidity were found. However, most authors using the term did not define it. The use of clearly defined terms in the literature is recommended until a general consensus on the terminology of multiple coexistent diseases is reached.
The Experience of Adults with Multimorbidity: A Qualitative Study
Authors: Duguay Cynthia , Gallagher Frances , Fortin Martin 
Published: June 2014

Background Findings from several countries indicate that the prevalence of multimorbidity is very high among clients of primary healthcare. A deeper understanding of patients’ experiences from their own perspective can greatly enrich any intervention to help them live as well as possible with multimorbidity. Objective To describe the fundamental structure of adults’ experience with multimorbidity. Design A phenomenological study was undertaken to describe the experiences of 11 adults with multimorbidity. These adults participated in two semi-structured interviews, the content of which was rigorously analyzed. Results At the core of the study participants’ multimorbidity experience are the impression of aging prematurely, difficulties with self-care management, and issues with access to the healthcare system, which contribute to the problem's complexity. Despite these issues, participants with multimorbidity report attempting to take control of their situation and adjusting to daily living. Conclusions The description of this experience, through the systemic vision of participants, provides a better understanding of the realities experienced by people with multimorbidity.
Islam and Medical Science: Evidence from Malaysian and Indonesian Fatāwā, 1960-1995
Authors: Hooker M.B. 
Published: June 2014

The purpose of this paperis to illustrate some of the dilemmas in which Islam finds itself with respect to advamces in modern medical science. This is of course a very large subject and all I can do here is to take a very small sample of problems as expressed in fatawa (legal rulings-see futher below) over the past thirty years. Coincidentally, these are also the years which have seen tremendous advances in medicine and the ways in which we can now treat (or mistreat?) the human body.DOI: 10.15408/sdi.v4i4.764
Christian-Muslim Relations in Indonesia: Five Challenges of the Twenty-First Century
Authors: Rabi Ibrahim Abu 
Published: June 2014

This paper - inspired by the "International Conference on Muslim-Christian Relations: Past, Present, and Future Dialogue and Cooperation", in Jakarta, August 1997 - discussed the challenges of Indonesia in relation to Christian-Muslim relations into the century 21.In August 1997, a major conference on Christian-Muslim relations and the challenges of religious plulalism in contemporary Indonesia was convenced at the Horison Hotel in Jakarta, Indonesia. DOI: 10.15408/sdi.v5i1.758
K.H. Hasyim Asy’ari’s Contribution to Indonesian Independence
Authors: Khuluq Lathiful 
Published: June 2014

An important note that should be emphasized is that the physical history of the Indonesian revolution are rarely included the involvement of the clergy or religious leaders. The key role played by K.H. Hasyim through political fatwa, which is further supported by the widespread ideology of jihad in the war of independence, has contributed important sheet of the neglected history.DOI: 10.15408/sdi.v5i1.760