bluuebunny/crossref_metadata_2025_split huggingface dataset:
KAYSERİ SELÇUKLU UYGARLIĞI MÜZESİ'NDE BULUNAN FİGÜRLÜ MADENİ MAŞRAPA
Authors: ÖZDEMİR Yurdagül , KAYIN Ayben 
Published: June 2024

Çalışmanın konusunu Kayseri Selçuklu Uygarlığı Müzesi’nde bulunan figürlü, madeni maşrapa oluşturmaktadır. Satın alma yoluyla müze koleksiyonuna dahil edilen eser, gövdesi üstünde bulunan figürlü süslemeleri ile ünik özelliktedir. Bakır alaşımlı tunç malzemeden döküm tekniği ile yapılmış olan eser, konik kısa halka kaideli, armudi gövdelidir. Ağıza doğru hafifçe dışarıya açılan konik bir boyuna sahip eserin gövdesi, sekizgen formda olup her bir köşe, balık sırtı motifi ile süslenmiştir. Bu sekiz kenar içerisinde bağdaş kurup oturan insan figürleri ve çeşitli süslemelere sahip rozetler bulunmaktadır. Eserin boyun kısmı üstünde ise nesih hatlı, sahibine iyi dilekler içeren bir yazı şeridi yer almaktadır. Eser, içte ve dışta yoğun korozyonlu olup restorasyon geçirmiştir.
Çalışmamızın amacı, eseri form ve süsleme özellikleri ile ayrıntılı bir şekilde ele alıp tanıtmak ve bu özelliklerine göre benzer örneklerle ilişkilendirerek tarihlendirme önerisinde bulunmaktır. Eser, gövdesinde bulunan süslemeleriyle ünik özellikte olup, yapılan araştırmalarda birebir aynı örnek bulunamamakla birlikte, yurtdışı müzelerinde süsleme ve form açısından benzer nitelikte az sayıda eserle karşılaşılmıştır. Çalışmamızda ele aldığımız maşrapa, malzeme, form, çokgen gövdenin köşelerindeki balık sırtı motifli süslemeleri, figürlerin yüz, kıyafet ve başlık detayları ve gövdenin alt kısmında bulunan rozetler gibi unsurlarla benzer örneklerle ilişkilendirilerek değerlendirilmiştir. Satın alma yolu ile Kayseri Selçuklu Uygarlığı Müzesi koleksiyonuna dahil edilen eserin üretim yerine ilişkin kesin bir şey söylemek mümkün değildir. Ancak eserin ikonografik özellikleri ve üstündeki yazının özelliklerine bakılarak Selçuklu dönemine tarihlendirilebileceği önerilmiştir.
Evaluation of reproductive hormones and histological of ovary in female rats treatment with dexamethasone
Authors: Talib Al-Muswie Rana 
Published: June 2024

The present study aimed to investigate the effect of dexamethasone Concentration on reproductive hormones and histochange of ovary in female’s rats. Twenty four adult female rats (Rattus norvegicus) were used. They were divided into four groups, (6) rats for each group. The first group (A) treated with normal saline for three months as a control group, the second group (B) treated with low dose dexamethasone (10 mg/kg/day) for three months, the third group(C) treated with intermediate dose dexamethasone for three months (20 mg/kg/day), and the fourth group (D) treated with high dose dexamethasone (40 mg/kg/day) for three months. The result indicated a significant increase in FSH and LH levels in all treated groups with dexamethasone (B, C and D) groups compared with control group. Also, there was a significant increase in FSH and LH levels in group B compared with C and D groups, with a significant increase in C compare with D (table 1 and 2). The results of histological change in ovary showed effect on all the follicles stimulation in group(B,C) treated with low doses and mid doses compare with control group and hyperplasia of theca and granulosa cells of ovarian treated with high doses groups (D) sections for three month, when compared with control group which show normal histological features . The study concludes that the abuse of dexamethasone caused side effect to woman which used it.
Web-based imagery behavioral activation (WIMBA): Study protocol for a randomized controlled trial testing the effects, acceptability, and feasibility of a mental imagery activity scheduling training delivered online
Authors: Heise Max , Bruijniks Sanne J. E. , Renner Fritz 
Published: June 2024

Background
Behavioral activation (BA) is an effective and efficacious treatment for depression. Activity scheduling is the central treatment component of BA and involves planning of potentially enjoyable and rewarding activities. Evidence from non-clinical studies suggests that mental imagery simulations of planned activities can increase motivation and anticipated pleasure for these activities.

Method
We describe a randomized controlled trial testing a mental imagery activity scheduling training delivered online in four weekly sessions (total training duration approximately 90 minutes) in a sample meeting diagnostic criteria of a major depressive episode, as indicated by the Diagnostic Short-Interview for Mental Disorders (Mini-DIPS), and not currently receiving treatment. Participants (N = 140) will be randomized to either mental imagery activity scheduling or a wait-list control condition. Depressive symptoms (BDI-II) and behavioral activation (BADS) are the primary outcomes; BDI-II will be measured at Session 1, Session 4, and at two-week follow-up, BADS at Sessions 1-4 and at two-week follow-up.

Discussion
It is discussed how the expected results may reflect mechanisms and effects of a mental imagery activity scheduling training delivered online in a sample of individuals with depression. Concluding we outline next steps for future research and highlight the potential of this novel treatment for dissemination in the wider community and integration into routine care.
Strength Behavior Analysis of Self-healing Concrete Using Bacteria and Silica Gel: A Comparative Study
Authors: Subramanian Ramakrishnan , Kesavan Sanjay , Sevugaperumal Sathrapathi , Sivakumar Shanthanu 
Published: June 2024

Concrete cracking is a significant worry in the construction sector, and infrastructure maintenance is becoming increasingly important in the present landscape. The expenditures of inspections, repairs, and maintenance are not only unwelcome but also have negative environmental consequences. The availability of self-healing agents in self-healing concrete (SHC) may be handled in these conditions with solid integrations. Self-healing concrete has the specific benefit of detecting the emergence of fractures in SHC-made concrete pieces and initiating a self-repair process without human involvement. This paper compares two alternative concrete healing methods and offers the findings of a complete experimental examination of self-healing concrete. In this study, silica and polymer-based gels were used along with Bacillus subtilis bacteria in separate experiments as weight-based alternatives for cement. The mechanical properties of various concrete mixes were evaluated using the self-healing studies by silica-based polymers and bacillus bacteria. The optimum dose level has been identified for the usage of silica gel and bacillus bacteria in the concrete. These findings provide vital insights into deploying self-healing concrete and its potential to handle concrete cracking concerns more effectively.
Un análisis arquegenealógico de los establecimientos religiosos en Tocantins
Authors: Soares Thiago Barbosa 
Published: June 2024

El objetivo de este artículo es examinar las relaciones de poder implicadas en la constitución de instituciones en el estado de Tocantins, especialmente los establecimientos religiosos asociados a la salud y a la educación. Para ello, hace uso del reconocido método cualitativo-interpretativo de Análisis del Discurso dirigido a la descripción heurística de los significados presentes en el artículo titulado "Tocantins tiene más establecimientos religiosos que instituciones de educación y salud, revela IBGE" (JARDIM, 2024), publicado en el periódico Opção. De esta forma, se movilizan las nociones de dispositivo, enunciación, formación discursiva y episteme, a partir de las cuales se verticaliza la lectura del objeto esbozado. Como resultado de esta investigación, se verificaron los constituyentes internos del enunciado de la noticia, la alineación del dispositivo y el anclaje del saber en el objeto en una formación discursiva progresiva y una episteme igualitaria, más allá del alcance de la proposición esbozada para este artículo.
Palabras clave: Discurso del Norte. Establecimientos religiosos. Tocantins.
Profile of Primary Brain Tumor Patients Who Received Radiotherapy at Hasan Sadikin General Hospital Bandung in 2020-2021
Authors: Rahmawaty Siti Fira , Kusumadjati Adji , Utama Marhendra Satria 
Published: June 2024

Background: A brain tumor is a tumor that is most known for its dangerous progressivity. Brain tumor is classified into primary and metastatic types. One of the management for primary brain tumors is radiotherapy. This study aims to elucidate the medical profiles and Karnofsky Performance Status (KPS) of patients with primary brain tumors with radiotherapy in Hasan Sadikin General Hospital based on a hospital-based cancer registry (HCBR) in 2020-2021.Methods: This study was conducted with a descriptive method. The sampling technique was total sampling using 22 medical records of primary brain tumor patients with radiotherapy from the year 2020-2021 which were registered in HCBR at the Radiotherapy Department, Hasan Sadikin General Hospital.Results: Primary brain tumor patients with radiotherapy were mostly from the 25-34 years age group (27.3%), male gender (68.2%), with a regional origin of West Priangan (45.5%), the chief complaint was headache (45.5%), with topography presence of overlapping lesion in the brain (ICD-O code C71.8) (27.3%), histopathological type is predominantly astrocytic tumors (22.7%), majority of patients underwent subtotal resection (59.1%), adjuvant radiation therapy was mostly indicated (40.9%), with all patients using Linac external beam radiotherapy (EBRT) radiation device. Almost all patients can finish radiotherapy (95.5%). The waiting time for radiotherapy is mostly 5-6 weeks (31.8%).Conclusions: Primary brain tumor infects more men than women, with a predominant age group of 25-34 years old. Histopathological findings are mostly of the astrocystic tumor type with most chief complain being headaches. The most common treatment is subtotal resection followed by radiotherapy using EBRT Linac with a positive one-year-postradiotherapy prognosis.
Differentiation of Microvessel Density Based on The Breast Cancer Patient Characteristics Including Age, Stage, Tumor Size, and Lymph Node Metastasis
Authors: Salsabila Tasya , Pratiwi Sari Eka , Trianto Heru Fajar , Ilmiawan Muhammad In'am , Lestari Desriani , Fitrianingrum Iit , Hartono Henky 
Published: June 2024

Background: Breast cancer is the most common malignant tumor in the world and Indonesia. One well-known prognostic marker is microvessel density (MVD), the numerical value of angiogenesis. In recent years, it has been recognized that tumor growth depends on angiogenesis. Therefore, this study aimed to determine the differentiation of MVD based on the breast cancer patients' characteristics including age, stage, tumor size, and lymph node metastasis in the Anatomical Pathology Laboratory of Soedarso Hospital. Methods: This research was an observational study with a cross-sectional approach. The study was conducted by observing the slides of Hematoxylin-Eosin (HE) in breast cancer patients. Samples were taken using the total sampling technique. The samples were observed by two observers. 51 tissue preparations met the inclusions and exclusions criteria. MVD cut-off points are taken by calculating the median. Research analysis was using the Kruskal-Wallis test in SPSS version 24. Results: All samples of this study were women and had invasive ductal carcinoma. Breast cancer tends to occur in patients aged 48-53 years, has stage III, lymph node metastasis (N2). The patients have a low MVD rate but have a large tumor size (T4). Kruskal Wallis test showed that there was a differentiation of MVD based on age (p = 0.029). While, there was no differentiation of MVD based on stage (p=0.974), tumor size (0.069), and lymph node metastasis (0.571). Conclusions: There was a differentiation of MVD based on the age of breast cancer patients in the Anatomical Pathology Laboratory at Soedarso Hospital.
Association between genetically proxied glucosamine and risk of cancer and non-neoplastic disease: A Mendelian randomization study
Authors: Wu Yingtong , Che Yinggang , Zhang Yong , Xiong Yanlu , Shu Chen , Jiang Jun , Li Gaozhi , Guo Lin , Qiao Tianyun , Li Shuwen , Li Ou , Chang Ning , Zhang Xinxin , Zhang Minzhe , Qiu Dan , Xi Hangtian , Li Jinggeng , Chen Xiangxiang , Ye Mingxiang , Zhang Jian 
Published: June 2024

IntroductionObservational investigations have examined the impact of glucosamine use on the risk of cancer and non-neoplastic diseases. However, the findings from these studies face limitations arising from confounding variables, reverse causation, and conflicting reports. Consequently, the establishment of a causal relationship between habitual glucosamine consumption and the risk of cancer and non-neoplastic diseases necessitates further investigation.MethodsFor Mendelian randomization (MR) investigation, we opted to employ single-nucleotide polymorphisms (SNPs) as instruments that exhibit robust associations with habitual glucosamine consumption. We obtained the corresponding effect estimates of these SNPs on the risk of cancer and non-neoplastic diseases by extracting summary data for genetic instruments linked to 49 varied cancer types amounting to 378,284 cases and 533,969 controls, as well as 20 non-neoplastic diseases encompassing 292,270 cases and 842,829 controls. Apart from the primary analysis utilizing inverse-variance weighted MR, we conducted two supplementary approaches to account for potential pleiotropy (MR-Egger and weighted median) and assessed their respective MR estimates. Furthermore, the results of the leave-one-out analysis revealed that there were no outlying instruments.ResultsOur results suggest divergence from accepted biological understanding, suggesting that genetically predicted glucosamine utilization may be linked to an increased vulnerability to specific illnesses, as evidenced by increased odds ratios and confidence intervals (95% CI) for diseases, such as malignant neoplasm of the eye and adnexa (2.47 [1.34–4.55]), benign neoplasm of the liver/bile ducts (2.12 [1.32–3.43]), benign neoplasm of the larynx (2.01 [1.36–2.96]), melanoma (1.74 [1.17–2.59]), follicular lymphoma (1.50 [1.06–2.11]), autoimmune thyroiditis (2.47 [1.49–4.08]), and autoimmune hyperthyroidism (1.93 [1.17–3.18]). In contrast to prior observational research, our genetic investigations demonstrate a positive correlation between habitual glucosamine consumption and an elevated risk of sigmoid colon cancer, lung adenocarcinoma, and benign neoplasm of the thyroid gland.ConclusionCasting doubt on the purported purely beneficial association between glucosamine ingestion and prevention of neoplastic and non-neoplastic diseases, habitual glucosamine ingestion exhibits dichotomous effects on disease outcomes. Endorsing the habitual consumption of glucosamine as a preventative measure against neoplastic and non-neoplastic diseases cannot be supported.
The application of the BOPPPS model in the ward rounds of nurses’ standardized training in Southwest China: a mixed methods study
Authors: Shen Ying 
Published: June 2024

BackgroundTeaching ward rounds are the main teaching method used to develop clinical skills in standardized nursing training. However, the existing methods lack of cultivation of comprehensive ability and humanistic care for nurses, cannot meet the requirements of standardized training for nurses. BOPPPS (bridge-in, objective, pre-assessment, participatory Learning, post-assessment, and summary) is a student-centered teaching model that has been proven to enhance classroom teaching effectiveness. Therefore, the BOPPPS model was applied and its effectiveness in standardized nursing training was evaluated.MethodsIn total, 260 nursing students were randomly allocated to two groups: the experimental group used the BOPPPS model and the control group used the traditional teaching model. This study used a mixed quantitative and qualitative research method to evaluate the effectiveness of the BOPPPS model.ResultsThe quantitative results were as follows: no significant difference in baseline scores was observed between the two groups before training. After training, the theory and practical scores in the experimental group were significantly higher than that of the control group. Similarly, students in the experimental group presented higher comprehensive ability scores than their counterparts. The students in the experimental group also exhibited higher satisfaction compared to the control group, while there was no difference in teacher satisfaction scores between the two groups (p = 0.323). Qualitative data showed that the vast majority of nurses and teachers agreed on the value of BOPPPS training.ConclusionCompared to traditional teaching methods, the BOPPPS model was more effective in standardized nursing training. We recommend applying the BOPPPS model to nursing training.
Calibration trial of an innovative medical device (NEVVA©) for the evaluation of pain in non-communicating patients in the intensive care unit
Authors: Bellal Mathieu , Lelandais Julien , Chabin Thomas , Heudron Aurélie , Gourmelon Thomas , Bauduin Pierrick , Cuchet Pierre , Daubin Cédric , De Carvalho Ribeiro Célia , Delcampe Augustin , Goursaud Suzanne , Joret Aurélie , Mombrun Martin , Valette Xavier , Cerasuolo Damiano , Morello Rémy , Mordel Patrick , Chaillot Fabien , Dutheil Jean Jacques , Vivien Denis , Du Cheyron Damien 
Published: June 2024

BackgroundPain management is an essential and complex issue for non-communicative patients undergoing sedation in the intensive care unit (ICU). The Behavioral Pain Scale (BPS), although not perfect for assessing behavioral pain, is the gold standard based partly on clinical facial expression. NEVVA©, an automatic pain assessment tool based on facial expressions in critically ill patients, is a much-needed innovative medical device.MethodsIn this prospective pilot study, we recorded the facial expressions of critically ill patients in the medical ICU of Caen University Hospital using the iPhone and Smart Motion Tracking System (SMTS) software with the Facial Action Coding System (FACS) to measure human facial expressions metrically during sedation weaning. Analyses were recorded continuously, and BPS scores were collected hourly over two 8 h periods per day for 3 consecutive days. For this first stage, calibration of the innovative NEVVA© medical device algorithm was obtained by comparison with the reference pain scale (BPS).ResultsThirty participants were enrolled between March and July 2022. To assess the acute severity of illness, the Sequential Organ Failure Assessment (SOFA) and the Simplified Acute Physiology Score (SAPS II) were recorded on ICU admission and were 9 and 47, respectively. All participants had deep sedation, assessed by a Richmond Agitation and Sedation scale (RASS) score of less than or equal to −4 at the time of inclusion. One thousand and six BPS recordings were obtained, and 130 recordings were retained for final calibration: 108 BPS recordings corresponding to the absence of pain and 22 BPS recordings corresponding to the presence of pain. Due to the small size of the dataset, a leave-one-subject-out cross-validation (LOSO-CV) strategy was performed, and the training results obtained the receiver operating characteristic (ROC) curve with an area under the curve (AUC) of 0.792. This model has a sensitivity of 81.8% and a specificity of 72.2%.ConclusionThis pilot study calibrated the NEVVA© medical device and showed the feasibility of continuous facial expression analysis for pain monitoring in ICU patients. The next step will be to correlate this device with the BPS scale.
Comparison of various doses of oral cannabidiol for treating refractory epilepsy indications: a network meta-analysis
Authors: Wang Xin , Zhu Haiyan , Liu Tao , Guo Zhi , Zhao Chenyang , He Zhiyi , Zheng Wenxu 
Published: June 2024

AimTo evaluate the comparative efficacy and safety of various doses of oral cannabidiol (CBD) in treating refractory epilepsy indications, thus providing more informative evidence for clinical decision-making.MethodsA literature search of PubMed, Embase, the Cochrane library, and Web of Science (WoS) was performed to retrieve relevant randomized controlled trials (RCTs) that compared different doses of oral CBD with placebo or each other in refractory epilepsy indications. The search was limited from the inception of each database to January 3, 2023. Relative risk [RR] with a 95% confidence interval [CI] was used to express results. STATA/SE 14 was employed for network meta-analysis.ResultsSix RCTs involving 972 patients were included in the final data analysis. Network meta-analysis showed that, CBD10 (10 mg/kg/day) (RR: 1.77, 95%CI: 1.28 to 2.44), CBD20 (20 mg/kg/day) (RR: 1.91, 95%CI: 1.49 to 2.46), CBD25 (25 mg/kg/day) (RR: 1.61, 95%CI: 0.96 to 2.70), and CBD50 (50 mg/kg/day) (RR: 1.78, 95%CI: 1.07 to 2.94) were associated with higher antiseizure efficacy although the pooled result for CBD25 was only close to significant. In addition, in terms of the risk of treatment-emergent adverse events (TEAEs), the difference between different doses is not significant. However, CBD20 ranked first in terms of antiseizure efficacy, followed by CBD50, CBD10, and CBD25. For TEAEs, CBD25 ranked first, followed by CBD10, CBD50, CBD5, and CBD20.ConclusionFor refractory indications, CBD20 may be optimal option for antiseizure efficacy; however, CBD25 may be best for TEAEs. Therefore, an appropriate dose of oral CBD should be selected based on the actual situation. Due to the limitations of eligible studies and the limited sample size, more studies are needed in the future to validate our findings.
Early life malnutrition and risk of T2DM adulthood: evidence from the lower socioeconomic status of northwest Chinese population
Authors: Shi Hongjuan , Yang Danyu , Ma Ling , Cheng Yin , Liu Yining , Ma Jinyu , Tong Huitian , Shi Chao 
Published: June 2024

ObjectiveThis study aimed to explore whether famine exposure during early life are associated with a high risk of Type 2 Diabetes Mellitus (T2DM) in adulthood and the role of socioeconomic status (SES) on this effect.Materials and methodsWe conducted a secondary data analysis based on data from a cross-sectional survey, collected 3,355 participants born between January 1, 1941 and December 31, 1966. Participants were categorized into four groups based on their date of birth, unexposed (individuals born in 1963–1966), infant exposed (individuals born in 1959–1962), childhood exposed (individuals born in 1949–1958), and adolescent exposed (born in 1941–1948). The association of famine exposure with T2DM risk in adults and conducted separately in plain area and mountain area was assessed using logistics regression model.Result22.35% of participants were diagnosed with T2DM, of which 43.47% were from the childhood famine-exposed group, representing the highest proportion among all subgroups (p &lt; 0.001). Participants exposed to famine during childhood and adolescence from the lower SES mountain areas showed a significantly higher prevalence of T2DM in adulthood than those from the plain areas (p &lt; 0.001). The adolescence stage exposed famine will increase the risk of T2DM in the mountain area (OR 2.46, 95% CI 1.61, 3.77).ConclusionNo strong evidence demonstrates that exposure to famine during the early life stage increases the risk of developing T2DM in adulthood. However, populations with lower SES are likely to be exposed to more risk factors for T2DM.