bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explicitation and Implicitation in Arabic- English Translation of Institutional Academic Correspondence
Authors: Al Hammadi Nada Mohamed , Yagi Sane Mo , Fareh Shehdeh 
Published: June 2024

Within the context of university communication, the choice of translation strategies can significantly impact the clarity and effectiveness of academic correspondence. This study investigates the role of explicitation and implicitation in translating from English (source language) to Arabic (target language). We explore how these strategies manifest in institutional academic correspondence (circulars and memos) and determine which strategy is more prevalent. Skopos Theory serves as the theoretical framework for this research. The study analyzed a corpus of 196 academic documents issued by the University of Sharjah between 2014 and 2020. An extended version of Klaudy's (2009) classification model was employed to identify instances of explicitation and implicitation across various linguistic levels (syntactic, semantic, stylistic, textual, and pragmatic). Our findings reveal a preference for implicitation in the English source texts compared to the Arabic translations. Furthermore, the analysis identified diverse manifestations of both strategies across different linguistic levels. The study concludes that explicitation and implicitation are both utilized in academic correspondence translation, but with varying frequencies.
Analisis Struktur Genetik dan Filogenetik Bakteri Lactobacillus Plantarum yang Diisiolasi dari Produk Pangan
Authors: Karni Ine , Nalurita Indah , Gemma Pravitri Kartika , Naufali Muhammad Nizhar , Meikapasa Ni Wayan Putu 
Published: June 2024

Lactobacillus plantarum (L. plantarum) adalah salah satu jenis bakteri asam laktat (BAL) yang dapat mengubah glukosa menjadi asam laktat. L. plantarum sebagian besar dapat ditemukan di susu, daging, sayuran fermentasi, dan saluran pencernaan manusia. Bakteri L. plantarum memiliki beberapa strain, yang dimana masing-masing strain memiliki fungsi yang baik dalm fermentasi pangan dan kesehatan. Untuk memahami perkembangan sejarah evolusi suatu organisme, diperlukan penggunaan filogeni sebagai dasar ilmu sistematika dalam evolusi biologis. Tujuan penelitian ini untuk mengetahui struktur genetik dan tingkat kekerabatan bakteri L. plantarum yang diisolasi dari produk pangan. Data yang digunakan dalam penelitian ini adalah data sekunder yang diambil pada GenBank berupa urutan nukleotida dari bakteri L. plantarum yang kemudian di alaigment menggunakan clustal W pada aplikasi Bioedit, kemudian dilakukan analisis struktur genetik dan filogenetik menggunakan aplikasi MEGA 7. Hasil penelitian menunjukkan bahwa probabilitas substitusi tertinggi terdeteksi pada basa G, diikuti oleh basa A, T/U, dan C. Strain L. plantarum yang memiliki tingkat kekerabatan paling tinggi yaitu strain dengan kode GenBank AY424355.1 dan AJ640082.1 dengan nilai bootsrep adalah 99. Topologi pohon filogenetik yang dihasilkan adalah monofiletik, yang berarti bahwa semua anggota dalam kelompok tersebut berasal dari satu leluhur yang sama yang mewariskan sifat genetik, morfologi, dan biokimia kepada keturunannya.
Urinary hyaluronidase activity is closely related to vasopressinergic system following an oral water load in men: a potential role in blood pressure regulation and early stages of hypertension development
Authors: Calvi Anna , Bongrani Alice , Verzicco Ignazio , Figus Giuliano , Vicini Vanni , Coghi Pietro , Montanari Alberto , Cabassi Aderville 
Published: June 2024

IntroductionBlood pressure (BP) regulation is a complex process involving several factors, among which water-sodium balance holds a prominent place. Arginin-vasopressin (AVP), a key player in water metabolism, has been evoked in hypertension development since the 1980s, but, to date, the matter is still controversial. Hyaluronic acid metabolism has been reported to be involved in renal water management, and AVP appears to increase hyaluronidase activity resulting in decreased high-molecular-weight hyaluronan content in the renal interstitium, facilitating water reabsorption in collecting ducts. Hence, our aim was to evaluate urinary hyaluronidase activity in response to an oral water load in hypertensive patients (HT, n=21) compared to normotensive subjects with (NT+, n=36) and without (NT-, n=29) a family history of hypertension, and to study its association with BP and AVP system activation, expressed by serum copeptin levels and urine Aquaporin 2 (AQP2)/creatinine ratio.MethodsEighty-six Caucasian men were studied. Water load test consisted in oral administration of 15–20 ml of water/kg body weight over 40–45 min. BP, heart rate, serum copeptin, urine hyaluronidase activity and AQP2 were monitored for 4 hours.ResultsIn response to water drinking, BP raised in all groups with a peak at 20–40 min. Baseline levels of serum copeptin, urinary hyaluronidase activity and AQP2/creatinine ratio were similar among groups and all decreased after water load, reaching their nadir at 120 min and then gradually recovering to baseline values. Significantly, a blunted reduction in serum copeptin, urinary hyaluronidase activity and AQP2/creatinine ratio was observed in NT+ compared to NT- subjects. A strong positive correlation was also found between urinary hyaluronidase activity and AQP2/creatinine ratio, and, although limited to the NT- group, both parameters were positively associated with systolic BP.DiscussionOur results demonstrate for the first time the existence in men of a close association between urinary hyaluronidase activity and vasopressinergic system and suggest that NT+ subjects have a reduced ability to respond to water loading possibly contributing to the blood volume expansion involved in early-stage hypertension. Considering these data, AVP could play a central role in BP regulation by affecting water metabolism through both hyaluronidase activity and AQP2 channel expression.
Epidemiology of potential drug- drug interactions in hospitalized patients with type 2 diabetes mellitus in China: a retrospective study
Authors: Ren Weifang , Liu Yujuan , Jiang Huaqiao , Lv Xiaoqun , Zhang Ning 
Published: June 2024

BackgroundCombination therapy was associated with an increased risk of drug- drug interactions (DDIs) in patients with type 2 diabetes mellitus (T2DM). The present study aimed to investigate the epidemiology of potential DDIs (pDDIs), including potential chemical drug-drug interactions (pCDIs) and potential herb-drug interactions (pHDIs), and classify the influencing factors of pDDIs in these patients.MethodsA retrospective study of the epidemiology of pDDIs among T2DM hospitalized patients older than 18 years and treated with at least two drugs during hospitalization was conducted over a 12-month period in 2019. PDDIs were identified with C (monitor therapy), D (consider therapy modification), and X (avoid combination) risk ratings. Binary logistic regression was used to analyze the risk factors of pDDIs.ResultsA total of 6796 pDDIs were identified from 737 T2DM hospitalized patients during hospitalization, with 0.87% classified as X risk rating, 13.39% as D risk rating. Additionally, 1753 pDDIs were identified after discharge, with 0.11% as X and 25.73% as D risk rating. The drug-drug association networks showed that the majority of pCDIs were associated with cardiovascular system drugs. Chlorphenamine-potassium chloride and danshen-warfarin were the most prevalent interacting pairs of pCDIs and pHDIs with X rating during hospitalization. Multivariate analysis indicated that the likelihood of developing over 4 pDDIs was significantly higher among T2DM patients who had received over 8 medications. The presence of pDDIs after discharge was strongly associated with the complications of T2DM and the number of discharge medications.ConclusionsT2DM patients were frequently exposed to pDDIs, including pCDIs and pHDIs, both during hospitalization and after discharge. Multi-drug combination was the primary risk factor for pDDIs. Strategies such as enhancing the monitoring and warning for pDDIs, increasing clinical pharmacological experience, as well as developing universally applicable clinical guidelines for pDDIs may be beneficial in reducing the incidence of potentially harmful drug-combinations.
Prevalence and associated factors of needlestick and sharp object injuries among healthcare workers in Ethiopia: a systematic review and meta-analysis
Authors: Kaweti Gudeta , Feleke Tihun 
Published: June 2024

BackgroundNeedlestick and sharp object injuries affect healthcare workers. However, there are limitations in the evidence available for informed decision-making by stakeholders, as individual research shows inconsistent results. Therefore, this study aims to assess the pooled prevalence of needlestick and sharp object injuries and their associated factors.MethodsMEDLINE/PubMed, EMBASE, Web of Science, Google Scholar, and other databases were searched from 5 September 2023 to 10 October 2023 using the following search terms: “Prevalence” OR “Burden” OR “Magnitude” AND “Associated factors” OR “related factors” OR “Risk factors” OR “determinants” OR “Predictors” AND “Needle stick Injury” OR “Sharp Injury” OR “Health care Workers” OR “ Health Care Personnel” OR “Nurses” OR “Professional” AND “Ethiopia”.ResultsThe pooled prevalence of needle sticks and sharp objects injury was 40.5 (95% CI: 35.0, 45.9). Needle-stick (AOR, 2.3; 95% CI: 1.6, 3.3, P &lt; 0.001], absence of routine precaution [AOR, 2.3; 95% CI: 1.1, 4.5, P &lt; 0.01] and lack of training (AOR = 2.4; 95% CI: 1.4, 4.1, p &lt; 0.001) had increased odds of needle-sticks and sharp objects injury.ConclusionForty percent of healthcare workers in Ethiopia have experienced needlestick and sharp object injuries. The identified factors included recapping, absence of routine precautions, and lack of training.Systematic Review RegistrationPROSPERO, identifier (CRD42023462311).
An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammation
Authors: Jiang Liqiong , Lunding Lars P. , Webber William S. , Beckmann Karsten , Azam Tania , Falkesgaard Højen Jesper , Amo-Aparicio Jesus , Dinarello Alberto , Nguyen Tom T. , Pessara Ulrich , Parera Daniel , Orlicky David J. , Fischer Stephan , Wegmann Michael , Dinarello Charles A. , Li Suzhao 
Published: June 2024

IntroductionInterleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is a key mediator ofautoinflammatory diseases associated with the development of macrophage activation syndrome (MAS).High levels of IL-18 correlate with MAS and COVID-19 severity and mortality, particularly in COVID-19patients with MAS. As an inflammation inducer, IL-18 binds its receptor IL-1 Receptor 5 (IL-1R5), leadingto the recruitment of the co-receptor, IL-1 Receptor 7 (IL-1R7). This heterotrimeric complex subsequentlyinitiates downstream signaling, resulting in local and systemic inflammation.MethodsWe reported earlier the development of a novel humanized monoclonal anti-human IL-1R7 antibody whichspecifically blocks the activity of human IL-18 and its inflammatory signaling in human cell and wholeblood cultures. In the current study, we further explored the strategy of blocking IL-1R7 inhyperinflammation in vivo using animal models.ResultsWe first identified an anti-mouse IL-1R7 antibody that significantly suppressed mouse IL-18 andlipopolysaccharide (LPS)-induced IFNg production in mouse splenocyte and peritoneal cell cultures. Whenapplied in vivo, the antibody reduced Propionibacterium acnes and LPS-induced liver injury and protectedmice from tissue and systemic hyperinflammation. Importantly, anti-IL-1R7 significantly inhibited plasma,liver cell and spleen cell IFNg production. Also, anti-IL-1R7 downregulated plasma TNFa, IL-6, IL-1b,MIP-2 production and the production of the liver enzyme ALT. In parallel, anti-IL-1R7 suppressed LPSinducedinflammatory cell infiltration in lungs and inhibited the subsequent IFNg production andinflammation in mice when assessed using an acute lung injury model.DiscussionAltogether, our data suggest that blocking IL-1R7 represents a potential therapeutic strategy to specificallymodulate IL-18-mediated hyperinflammation, warranting further investigation of its clinical application intreating IL-18-mediated diseases, including MAS and COVID-19.
Improving patient-centered mental health promotion in primary care in vulnerable communities through mindfulness training in Rio de Janeiro, Brazil
Authors: Teixeira Débora Silva , Fortes Sandra , Kestenberg Celia , Alves Kali , Campos Mônica Rodrigues , Neto Alfredo Oliveira , Ortega Francisco , García-Campayo Javier , Demarzo Marcelo 
Published: June 2024

IntroductionBrazilian Primary Health Care (PHC) is responsible for all-sanitary actions for a community-based population, including health promotion and mental health care. Mindfulness Based Health Promotion (MBHP) is an intervention that can promote self-care and psychosocial support in PHC.ObjectiveTo discuss the effects of mindfulness based psychosocial group interventions for health promotion in primary care units in Rio de Janeiro, Brazil.MethodsThe intervention was based on the MBHP model adapted for SUS. Nine groups were held in Rio de Janeiro. A quali-quanti research was held with two parts: (a) quantitative study, pre and after the 8 weeks intervention, evaluating the effect on mindfulness and self-compassion and their association with levels of anxiety, depression, and quality of life. (b) Qualitative research using Focus Groups with the participants to investigate their experience at the end of the mindfulness groups.Results and discussionSixty-two participants finished the 9 groups where 86% were women, mostly between 30 and 59 years of age and low income, and around 80% under regular medical care in PHC in SUS. In the studied sample 80% had at least one chronic health condition under treatment, including 42% with anxiety and 35% with depression. The effects included significant improvement in Anxiety and Depression and in Quality of Life, mainly in the psychological but also in the physical and interrelation domains. The qualitative study showed that most patients joined the group on the recommendation of health professionals for managing physical and mental health symptoms. Patients reported being able to use the practices taught in the sessions to manage symptoms such as insomnia and emotionally distressing situations in their daily lives. Including family members in mindfulness practices was a strategy to negotiate not only a space at home to meditate, but also to obtain a different approach to health problems. Participants pointed to mindfulness as a complementary therapeutic option to medication and psychotherapy.ConclusionMindfulness-Based Intervention have shown to be a feasible, well-accepted and efficacious method of offering psychosocial support and promoting well-being for low-income patients in primary care in LAMIC.
MassARRAY: a high-throughput solution for rapid detection of foodborne pathogens in real-world settings
Authors: Suebwongsa Namfon , Jiemsup Surasak , Santiyanont Pannita , Hirunpatrawong Piyapha , Aswapairin Pornsiri , Thongkum Monthathip , Panumars Prakaymars , Chokesajjawatee Nipa , Wongsrichai Supaporn , Koompa Pichet , Yongkiettrakul Suganya 
Published: June 2024

IntroductionBacterial foodborne pathogens pose a substantial global public health concern, prompting government agencies and public health organizations to establish food safety guidelines and regulations aimed at mitigating the risk of foodborne illness. The advent of DNA-based amplification coupled with mass spectrometry, known as MassARRAY analysis, has proven to be a highly precise, sensitive, high-throughput, and cost-effective method for bacterial detection. This study aimed to develop, validate, and evaluate a MassARRAY-based assay for the detection and identification of significant enteropathogenic bacteria.MethodsThe MassARRAY-based assay was developed for the detection of 10 crucial bacterial foodborne pathogens, including Campylobacter coli, Campylobacter jejuni, Clostridium perfringens, Escherichia coli, Enterococcus faecalis, Enterococcus faecium, Listeria monocytogenes, Salmonella spp., Shigella spp., and Staphylococcus aureus. The assay was optimized using the reference gDNA (n = 19), followed by validation using gDNA (n = 85) of reference and laboratory isolates. Additionally, the evaluation of the assay’s reaction using a mixture of gDNA from all nine targeted species was performed. The limit of detection of the developed MassARRAY-based assay was determined using bacterial cells. Moreover, the validation method for field samples was evaluated by comparing it with standard microbiological testing methods routinely analyzed.ResultsThe developed MassARRAY-based assay demonstrated 100% concordance with known bacterial pure cultures. The assay’s reaction using a mixture of gDNA from all nine targeted species revealed the MassARRAY’s capability to detect all targeted species in a single assay with the lowest concentration of 1 ng/μL of gDNA. The limits of detection of the assay range from 357 ± 101 to 282,000 ± 79,196 cells. Moreover, the validation of the assay in field samples revealed a 100% correlation between the data obtained from the standard microbiological method and the MassARRAY-based assay.DiscussionThese findings suggested that the developed MassARRAY-based assay exhibited the excellence in high-throughput detection of foodborne bacterial pathogens with high accuracy, reliability, and potential applicability within real-world field samples.
Enteral nutritional strategy during therapeutic hypothermia: who? when? what?
Authors: Costa Simonetta , Rizzo Irene Del , Fattore Simona , Serrao Francesca , Priolo Francesca , Corsello Mirta , Tiberi Eloisa , Tana Milena , Catalano Paola , Vento Giovanni 
Published: June 2024

BackgroundThere are no guidelines regarding enteral feeding (EF) of infants with hypoxic-ischemic encephalopathy (HIE) during and shortly after therapeutic hypothermia; consequently, clinical practice is, to date, still variable. The objective of this study is to assess whether a minimal EF strategy during therapeutic hypothermia may be associated with a shorter time to full EF of infants with HIE and to identify the clinical variables that independently affect the time to full EF.MethodsA retrospective study, covering the period from 1 January 2015 to 30 June 2022 was performed at the Neonatal Intensive Care Unit of the Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, which compared infants with HIE who received minimal EF during therapeutic hypothermia with those who did not.ResultsSeventy-eight infants received minimal EF during therapeutic hypothermia, while 75 did not. Infants who were fed reached full EF significantly faster than those who were not. Moreover, they received parenteral nutrition and maintained central venous lines for a shorter time. A multivariate analysis, taking into account the variable of clinical severity, confirmed that minimal EF is an independent beneficial factor for reaching full EF in a shorter time and mechanical ventilation and seizures are independent factors for a longer time to full EF.ConclusionsMinimal EF during therapeutic hypothermia is associated with a shorter time to full EF in stable infants with HIE. Further prospective studies are needed to better define the enteral nutrition strategy for infants during therapeutic hypothermia, regardless of the severity of clinical conditions.
Association between protein-to-energy ratio and overweight/obesity in children and adolescents in the United States: a cross-sectional study based on NHANES
Authors: Zhao Feng , Wang Yudan , Liu Zhaoyi , Wang Jiao , Xia Yinyin , Jiang Xuejun , Zhou Lixiao , Khan Ahmad , Cheng Shuqun , Zou Zhen , Chen Chengzhi , Qiu Jingfu 
Published: June 2024

BackgroundThe dietary protein proportion may be crucial in triggering overweight and obesity among children and adolescents.MethodsCross-sectional data from 4,336 children and adolescents who participated in the National Health and Nutrition Survey (NHANES) between 2011 and March 2020 were analyzed. Multivariate logistic regression was used to calculate odds ratio (OR) and 95% confidence interval (CI). Restricted cubic splines assessed the nonlinear relationships between dietary protein intake and the prevalence of overweight and obesity.ResultsAdjusted logistic regression models showed that each 1% increase in dietary protein proportion was associated with a 4% higher risk of overweight and obesity (OR = 1.04, 95% CI: 1.01–1.07). A nonlinear relationship was noted in children aged 6–11 years (P &lt; 0.05), as demonstrated by restricted cubic spline analysis. After dividing dietary protein intake into quartiles, the highest quartile had an adjusted OR of 2.07 (95% CI: 1.35, 3.16, P = 0.001) compared to the lowest, among children aged 6–11 years.ConclusionDietary protein intake is positively linked to overweight and obesity in American children, irrespective of individual characteristics and total energy consumption.
Permanent cutaneous vesicostomy: a pragmatic approach to safely manage lower urinary tract dysfunction in pediatric patients with chronic and life-limiting conditions and neuropathic bladders
Authors: Vallasciani Santiago , Al Saeedi Ahmed , Khalil Ibrahim A. , Mohamed Reem Babiker , Muneer Eshan , Abdelmaguid Nadra , Pippi Salle Joao Luiz 
Published: June 2024

IntroductionLower urinary tract dysfunction (LUTD) in cerebral palsy (CP) and other neuromuscular diseases can present with chronic retention that leads to hydronephrosis, recurrent urinary tract infections (UTI), and stone formation. Whenever the conservative treatment of LUTD fails for any reason, it is considered to be complicated LUTD, in which a surgical approach is warranted. Cutaneous vesicostomy (CV) is a simple, well-tolerated, and potentially reversible procedure that protects the upper tracts. We describe our experience using CV for this complex population.Materials and methodsChildren with CP and other neuromuscular diseases admitted to pediatric long-term care units for palliative care between 2015 and 2019 were included in the study. They present multi-system involvement, polypharmacy, and Gross Motor Function Classification System levels of 4 or 5. We retrospectively studied this population's indications and results of CV.ResultsOf the 52 admitted patients, 18 presented LUTD with UTI (n:18; 100%), stones (n:5; 28%), progressive hydroureteronephrosis (n:3; 17%), or stones (n:2; 11%). Conservative initial management (catheterizations, prophylaxis antibiotics) was effective in half the cases. The remaining nine were defined as complicated LUTD and underwent CV. After a mean follow-up of 11.3 months, the follow-up showed improved hydronephrosis in all nine (100%) patients. Recurrent UTIs were no longer seen in eight of nine patients, although three patients required bladder irrigations; bladder stones did not recur after CV; the kidney stones needed further intervention. Revision of the CV was required in two (11%) cases at 12 and 24 months postoperatively due to stoma stenosis.ConclusionCV is a relatively simple and effective procedure representing a pragmatic solution for managing complicated LUTD in complex long-term institutionalized pediatric palliative care patients with neuropathic bladders.