bluuebunny/crossref_metadata_2025_split huggingface dataset:
African Rainfall Climatology Version 2 for Famine Early Warning Systems
Authors: Novella Nicholas S. , Thiaw Wassila M. 
Published: September 2012

AbstractThis paper describes a new gridded, daily 29-yr precipitation estimation dataset centered over Africa at 0.1° spatial resolution. Called the African Rainfall Climatology, version 2 (ARC2), it is a revision of the first version of the ARC. Consistent with the operational Rainfall Estimation, version 2, algorithm (RFE2), ARC2 uses inputs from two sources: 1) 3-hourly geostationary infrared (IR) data centered over Africa from the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) and 2) quality-controlled Global Telecommunication System (GTS) gauge observations reporting 24-h rainfall accumulations over Africa. The main difference with ARC1 resides in the recalibration of all Meteosat First Generation (MFG) IR data (1983–2005). Results show that ARC2 is a major improvement over ARC1. It is consistent with other long-term datasets, such as the Global Precipitation Climatology Project (GPCP) and Climate Prediction Center (CPC) Merged Analysis of Precipitation (CMAP), with correlation coefficients of 0.86 over a 27-yr period. However, a marginal summer dry bias that occurs over West and East Africa is examined. Daily validation with independent gauge data shows RMSEs of 11.3, 13.4, and 14, respectively, for ARC2, Tropical Rainfall Measuring Mission Multisatellite Precipitation Analysis 3B42, version 6 (3B42v6), and the CPC morphing technique (CMORPH) for the West African summer season. The ARC2 RMSE is slightly higher for Ethiopia than those of CMORPH and 3B42v6. Both daily and monthly validations suggested that ARC2 underestimations may be attributed to the unavailability of daily GTS gauge reports in real time, and deficiencies in the satellite estimate associated with precipitation processes over coastal and orographic areas. However, ARC2 is expected to provide users with real-time monitoring of the daily evolution of precipitation, which is instrumental in improved decision making in famine early warning systems.
GPS Precipitable Water as a Diagnostic of the North American Monsoon in California and Nevada
Authors: Means James D. 
Published: September 2012

Abstract
Precipitable water derived from archived global positioning system (GPS) zenith travel-time delays is used to describe the seasonal and interannual variation of the North American monsoon in California and Nevada. A 3-hourly dataset of precipitable water from 2003 to 2009, for over 500 sites in California and Nevada using temperature and pressure interpolated from the North American Regional Reanalysis (NARR), is constructed to study the temporal and spatial extent of the North American monsoon in the desert regions of California and Nevada. The statistical distribution of precipitable water values is shown to delineate the region that is most often affected by the monsoonal influence. A normalized precipitable water index is employed to indicate when the monsoon starts and stops and to investigate spatial variability. The GPS network provides much higher spatial resolution than other meteorological networks using surface-based methods, such as dewpoint criteria and rainfall, and is seen to contain comparable ability in capturing temporal variations. This dataset reveals the northwestward propagation of the monsoon onset both synoptically and seasonally. The GPS observations indicate that in the mean the decay of the monsoon is less well defined than the onset. Seven-year reanalysis 700-mb geopotential height composites for the monsoon onset and 3 days prior indicate that the onset of the monsoon is associated with a shift in the synoptic pattern characterized by upper-level high pressure building from the east and offshore troughing retreating to the northwest.
Transient Climate Response in a Two-Layer Energy-Balance Model. Part I: Analytical Solution and Parameter Calibration Using CMIP5 AOGCM Experiments
Authors: Geoffroy O. , Saint-Martin D. , Olivié D. J. L. , Voldoire A. , Bellon G. , Tytéca S. 
Published: September 2012

AbstractThis is the first part of a series of two articles analyzing the global thermal properties of atmosphere–ocean coupled general circulation models (AOGCMs) within the framework of a two-layer energy-balance model (EBM). In this part, the general analytical solution of the system is given and two idealized climate change scenarios, one with a step forcing and one with a linear forcing, are discussed. These solutions give a didactic description of the contributions from the equilibrium response and of the fast and slow transient responses during a climate transition. Based on these analytical solutions, a simple and physically based procedure to calibrate the two-layer model parameters using an AOGCM step-forcing experiment is introduced. Using this procedure, the global thermal properties of 16 AOGCMs participating in phase 5 of the Coupled Model Intercomparison Project (CMIP5) are determined. It is shown that, for a given AOGCM, the EBM tuned with only the abrupt 4×CO2 experiment is able to reproduce with a very good accuracy the temperature evolution in both a step-forcing and a linear-forcing experiment. The role of the upper-ocean and deep-ocean heat uptakes in the fast and slow responses is also discussed. One of the main weaknesses of the simple EBM discussed in this part is its ability to represent the evolution of the top-of-the-atmosphere radiative imbalance in the transient regime. This issue is addressed in Part II by taking into account the efficacy factor of deep-ocean heat uptake.
Atmospheric Forcing of the Winter Air–Sea Heat Fluxes over the Northern Red Sea
Authors: Papadopoulos Vassilis P. , Abualnaja Yasser , Josey Simon A. , Bower Amy , Raitsos Dionysios E. , Kontoyiannis Harilaos , Hoteit Ibrahim 
Published: September 2012

Abstract
The influence of the atmospheric circulation on the winter air–sea heat fluxes over the northern Red Sea is investigated during the period 1985–2011. The analysis based on daily heat flux values reveals that most of the net surface heat exchange variability depends on the behavior of the turbulent components of the surface flux (the sum of the latent and sensible heat). The large-scale composite sea level pressure (SLP) maps corresponding to turbulent flux minima and maxima show distinct atmospheric circulation patterns associated with each case. In general, extreme heat loss (with turbulent flux lower than −400 W m−2) over the northern Red Sea is observed when anticyclonic conditions prevail over an area extending from the Mediterranean Sea to eastern Asia along with a recession of the equatorial African lows system. Subcenters of high pressure associated with this pattern generate the required steep SLP gradient that enhances the wind magnitude and transfers cold and dry air masses from higher latitudes. Conversely, turbulent flux maxima (heat loss minimization with values from −100 to −50 W m−2) are associated with prevailing low pressures over the eastern Mediterranean and an extended equatorial African low that reaches the southern part of the Red Sea. In this case, a smooth SLP field over the northern Red Sea results in weak winds over the area that in turn reduce the surface heat loss. At the same time, southerlies blowing along the main axis of the Red Sea transfer warm and humid air northward, favoring heat flux maxima.
Spatial Interpolation for Real-Time Rainfall Field Estimation in Areas with Complex Topography
Authors: Rogelis M. C. , Werner M. G. F. 
Published: September 2012

AbstractFor many hydrological applications interpolation of point rainfall measurements is needed. One such application is flood early warning, particularly where spatially distributed hydrological models are used. Operation in real time poses challenges to the interpolation procedure, as this should then both be automatic and efficiently provide robust interpolation of gauged data. The differences in performance of ordinary kriging, universal kriging, and kriging with external drift with individual and pooled variograms were assessed for 139 daily datasets with significant precipitation in a study area in Bogotá, Colombia. Interpolators were compared using the percentage of variability explained and the root-mean-square error found in cross validation, aiming at identifying a procedure for real-time interpolation. The results showed that interpolators using pooled variograms provide a performance comparable to when the interpolators were applied to the storms individually, showing that they can be used successfully for interpolation in real-time operation in the study area. The analysis identified limitations in the use of kriging with external drift. Only when the adjusted R2 between the secondary variables and precipitation is higher than the percentage of variability explained found in ordinary kriging, then kriging with external drift provided a consistent improvement. This interpolator was found to give a lower performance in all other cases. The distribution of precipitation over basins of interest for each of the storms, derived through sampling rainfall fields generated through conditional Gaussian simulation, shows that, while differences between the interpolators may appear to be significant, the variability of the precipitation volume is less significant.
Misinformation and Its Correction
Authors: Lewandowsky Stephan , Ecker Ullrich K. H. , Seifert Colleen M. , Schwarz Norbert , Cook John 
Published: September 2012

The widespread prevalence and persistence of misinformation in contemporary societies, such as the false belief that there is a link between childhood vaccinations and autism, is a matter of public concern. For example, the myths surrounding vaccinations, which prompted some parents to withhold immunization from their children, have led to a marked increase in vaccine-preventable disease, as well as unnecessary public expenditure on research and public-information campaigns aimed at rectifying the situation. We first examine the mechanisms by which such misinformation is disseminated in society, both inadvertently and purposely. Misinformation can originate from rumors but also from works of fiction, governments and politicians, and vested interests. Moreover, changes in the media landscape, including the arrival of the Internet, have fundamentally influenced the ways in which information is communicated and misinformation is spread. We next move to misinformation at the level of the individual, and review the cognitive factors that often render misinformation resistant to correction. We consider how people assess the truth of statements and what makes people believe certain things but not others. We look at people’s memory for misinformation and answer the questions of why retractions of misinformation are so ineffective in memory updating and why efforts to retract misinformation can even backfire and, ironically, increase misbelief. Though ideology and personal worldviews can be major obstacles for debiasing, there nonetheless are a number of effective techniques for reducing the impact of misinformation, and we pay special attention to these factors that aid in debiasing. We conclude by providing specific recommendations for the debunking of misinformation. These recommendations pertain to the ways in which corrections should be designed, structured, and applied in order to maximize their impact. Grounded in cognitive psychological theory, these recommendations may help practitioners—including journalists, health professionals, educators, and science communicators—design effective misinformation retractions, educational tools, and public-information campaigns.
Role of trehalose in heat and desiccation tolerance in the soil bacterium Rhizobium etli
Authors: Reina-Bueno Mercedes , Argandoña Montserrat , Nieto Joaquín J , Hidalgo-García Alba , Iglesias-Guerra Fernando , Delgado María J , Vargas Carmen 
Published: September 2012

Abstract

Background
The compatible solute trehalose is involved in the osmostress response of Rhizobium etli, the microsymbiont of Phaseolus vulgaris. In this work, we reconstructed trehalose metabolism in R. etli, and investigated its role in cellular adaptation and survival to heat and desiccation stress under free living conditions.

Results
Besides trehalose as major compatible solute, R. etli CE3 also accumulated glutamate and, if present in the medium, mannitol. Putative genes for trehalose synthesis (otsAB/treS/treZY), uptake (aglEFGK/thuEFGK) and degradation (thuAB/treC) were scattered among the chromosome and plasmids p42a, p42c, p42e, and p42f, and in some instances found redundant. Two copies of the otsA gene, encoding trehalose-6-P-synthase, were located in the chromosome (otsAch) and plasmid p42a (otsAa), and the latter seemed to be acquired by horizontal transfer. High temperature alone did not influence growth of R. etli, but a combination of high temperature and osmotic stress was more deleterious for growth than osmotic stress alone. Although high temperature induced some trehalose synthesis by R. etli, trehalose biosynthesis was mainly triggered by osmotic stress. However, an otsAch mutant, unable to synthesize trehalose in minimal medium, showed impaired growth at high temperature, suggesting that trehalose plays a role in thermoprotection of R. etli. Desiccation tolerance by R. etli wild type cells was dependent of high trehalose production by osmotic pre-conditioned cells. Cells of the mutant strain otsAch showed ca. 3-fold lower survival levels than the wild type strain after drying, and a null viability after 4 days storage.

Conclusions
Our findings suggest a beneficial effect of osmotic stress in R. etli tolerance to desiccation, and an important role of trehalose on the response of R. etli to high temperature and desiccation stress.
Restoration of dietary-fat induced blood–brain barrier dysfunction by anti-inflammatory lipid-modulating agents
Authors: Pallebage-Gamarallage Menuka , Lam Virginie , Takechi Ryusuke , Galloway Susan , Clark Karin , Mamo John 
Published: September 2012

Abstract

Background
Several studies have identified use of non-steroidal-anti-inflammatory drugs and statins for prevention of dementia, but their efficacy in slowing progression is not well understood. Cerebrovascular disturbances are common pathological feature of Alzheimer’s disease. We previously reported chronic ingestion of saturated fatty acids (SFA) compromises blood–brain barrier (BBB) integrity resulting in cerebral extravasation of plasma proteins and inflammation. However, the SFA-induced parenchymal accumulation of plasma proteins could be prevented by co-administration of some cholesterol lowering agents. Restoration of BBB dysfunction is clinically relevant, so the purpose of this study was to explore lipid-lowering agents could reverse BBB disturbances induced by chronic ingestion of SFA’s.

Methods
Wild-type mice were fed an SFA diet for 12 weeks to induce BBB dysfunction, and then randomised to receive atorvastatin, pravastatin or ibuprofen in combination with the SFA-rich diet for 2 or 8 weeks. Abundance of plasma-derived immunoglobulin-G (IgG) and amyloid-β enriched apolipoprotein (apo)-B lipoproteins within brain parenchyme were quantified utilising immunofluorescence microscopy.

Results
Atorvastatin treatment for 2 and 8 weeks restored BBB integrity, indicated by a substantial reduction of IgG and apo B, particularly within the hippocampus. Pravastatin, a water-soluble statin was less effective than atorvastatin (lipid-soluble). Statin effects were independent of changes in plasma lipid homeostasis. Ibuprofen, a lipid-soluble cyclooxygenase inhibitor attenuated cerebral accumulation of IgG and apo B as effectively as atorvastatin. Our findings are consistent with the drug effects being independent of plasma lipid homeostasis.

Conclusion
Our findings suggest that BBB dysfunction induced by chronic ingestion of SFA is reversible with timely introduction and sustained treatment with agents that suppress inflammation.
SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3
Authors: Song Guohua , Zong Chuanlong , Liu Qian , Si Yanhong , Liu Jie , Li Wei , Zhu Ping , Qin Shucun 
Published: September 2012

Abstract

Background
The single and combined effects of scavenger receptor-BI (SR-BI), ATP-binding cassette transporter (ABC) A1 and G1 on cholesterol efflux from Chinese Hamster Ovary (CHO) cells were investigated.

Results
When apolipoproteinA-I (apoA-I) was used as an acceptor, ABCA1 overexpression led to an increase in total cholesterol (TC) in medium which is attributable to a 2-fold increase in free cholesterol (FC) content. When high-density lipoprotein 3 (HDL3) was used as an acceptor, SR-BI overexpression not only promoted FC efflux, but also promoted the uptake of cholesteryl ester (CE) into cells, resulting in no TC varieties in medium. Overexpression of ABCG1 increased both the FC and CE levels in medium. However, when apoA-I and HDL3 were both used as acceptors, coexpression of SR-BI has no effect on ABCA1-mediated increased FC and TC accumulation in medium. Interestingly, coexpression of SR-BI with ABCG1 blocked the ABCG1-mediated cholesterol efflux to HDL3, mostly by promoting the reuptake of CE from the medium. Furthermore, co-immunoprecipitation experiments revealed that SR-BI interacted with ABCG1 in BHK cells overexpressing ABCG1 and SR-BI.

Conclusions
We found SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to HDL3.
Phenolic-glycolipid-1 and lipoarabinomannan preferentially modulate TCR- and CD28-triggered proximal biochemical events, leading to T-cell unresponsiveness in mycobacterial diseases
Authors: Dagur Pradeep Kumar , Sharma Bhawna , Upadhyay Rajni , Dua Bhavyata , Rizvi Arshad , Khan Naim Akhtar , Katoch Vishwa Mohan , Sengupta Utpal , Joshi Beenu 
Published: September 2012

AbstractBackgroundAdvanced stages of leprosy show T cell unresponsiveness and lipids of mycobacterial origin are speculated to modulate immune responses in these patients. Present study elucidates the role of phenolicglycolipid (PGL-1) and Mannose-capped lipoarabinomannan (Man-LAM) on TCR- and TCR/CD28- mediated signalling.ResultsWe observed that lipid antigens significantly inhibit proximal early signalling events like Zap-70 phosphorylation and calcium mobilization. Interestingly, these antigens preferentially curtailed TCR-triggered early downstream signalling events like p38 phosphorylation whereas potentiated that of Erk1/2. Further, at later stages inhibition of NFAT binding, IL-2 message, CD25 expression and T-cell blastogenesis by PGL-1 and Man-LAM was noted.ConclusionAltogether, we report that Man-LAM and PGL-1 preferentially interfere with TCR/CD28-triggered upstream cell signalling events, leading to reduced IL-2 secretion and T-cell blastogenesis which potentially could lead to immunosupression and thus, disease exacerbation, as noted in disease spectrum.
Alzheimer disease and platelets: how’s that relevant
Authors: Catricala Silvia , Torti Mauro , Ricevuti Giovanni 
Published: September 2012

Abstract
Alzheimer Disease (AD) is the most common neurodegenerative disorder worldwide, and account for 60% to 70% of all cases of progressive cognitive impairment in elderly patients. At the microscopic level distinctive features of AD are neurons and synapses degeneration, together with extensive amounts of senile plaques and neurofibrillars tangles. The degenerative process probably starts 20–30 years before the clinical onset of the disease. Senile plaques are composed of a central core of amyloid β peptide, Aβ, derived from the metabolism of the larger amyloid precursor protein, APP, which is expressed not only in the brain, but even in non neuronal tissues. More than 30 years ago, some studies reported that human platelets express APP and all the enzymatic activities necessary to process this protein through the same pathways described in the brain. Since then a large number of evidence has been accumulated to suggest that platelets may be a good peripheral model to study the metabolism of APP, and the pathophysiology of the onset of AD. In this review, we will summarize the current knowledge on the involvement of platelets in Alzheimer Disease. Although platelets are generally accepted as a suitable model for AD, the current scientific interest on this model is very high, because many concepts still remain debated and controversial. At the same time, however, these still unsolved divergences mirror a difficulty to establish constant parameters to better defined the role of platelets in AD.
Identification of BACE2 as an avid ß-amyloid-degrading protease
Authors: Abdul-Hay Samer O , Sahara Tomoko , McBride Melinda , Kang Dongcheul , Leissring Malcolm A 
Published: September 2012

Abstract

Background
Proteases that degrade the amyloid ß-protein (Aß) have emerged as key players in the etiology and potential treatment of Alzheimer’s disease (AD), but it is unlikely that all such proteases have been identified. To discover new Aß-degrading proteases (AßDPs), we conducted an unbiased, genome-scale, functional cDNA screen designed to identify proteases capable of lowering net Aß levels produced by cells, which were subsequently characterized for Aß-degrading activity using an array of downstream assays.

Results
The top hit emerging from the screen was ß-site amyloid precursor protein-cleaving enzyme 2 (BACE2), a rather unexpected finding given the well-established role of its close homolog, BACE1, in the production of Aß. BACE2 is known to be capable of lowering Aß levels via non-amyloidogenic processing of APP. However, in vitro, BACE2 was also found to be a particularly avid AßDP, with a catalytic efficiency exceeding all known AßDPs except insulin-degrading enzyme (IDE). BACE1 was also found to degrade Aß, albeit ~150-fold less efficiently than BACE2. Aß is cleaved by BACE2 at three peptide bonds—Phe19-Phe20, Phe20-Ala21, and Leu34-Met35—with the latter cleavage site being the initial and principal one. BACE2 overexpression in cultured cells was found to lower net Aß levels to a greater extent than multiple, well-established AßDPs, including neprilysin (NEP) and endothelin-converting enzyme-1 (ECE1), while showing comparable effectiveness to IDE.

Conclusions
This study identifies a new functional role for BACE2 as a potent AßDP. Based on its high catalytic efficiency, its ability to degrade Aß intracellularly, and other characteristics, BACE2 represents a particulary strong therapeutic candidate for the treatment or prevention of AD.