bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Physical Activity Interventions on Physical Self-Perception in College Students: A Systematic Review and Meta-Analysis
Authors: Yang Zhiling , Yang Zhiying , Ou Wengling , Zeng Qing , Huang Jiafu 
Published: August 2024

Background: Although the physical activities have demonstrated efficacy in improving physical self-perception, the findings of available studies in college students were conflicting. This review aimed to examine the effects of physical activity interventions on physical self-perception in college students. Methods: Web of Science, PubMed, Cochrane Library, EBSCOhost, Embase, Scopus, CNKI, WanFang, and Chinese Technical Periodicals were searched from inception to April 2024. Studies were included if they were randomized controlled trials (RCTs) or non-RCTs (non-RCTs) that examined the effects of physical activity interventions on college students’ physical self-perception. Random-effects models were used in meta-analyses to synthesize effect sizes. Results: Forty studies (17 RCTs and 23 non-RCTs) with 4955 participants were included in this meta-analysis. Overall, physical activity interventions had small to moderate significant effect on physical self-worth (standardized mean difference [SMD] = 0.44, P < .00001), perceived sports competence (SMD = 0.60, P < .00001), perceived physical condition (SMD = 0.45, P < .00001), perceived physical strength (SMD = 0.53, P < .00001), and perceived body attractiveness (SMD = 0.54, P < .00001). Significant differences were observed in study design (P = .031–.039), intervention type (P = .003–.031), and intervention duration (P = .002–.036) for some aspects of physical self-perception, such as perceived physical strength and perceived body attractiveness. Conclusions: Physical activity interventions have beneficial effects on physical self-perception in college students, especially those conducted for 12 weeks, 3 times or more per week, lasting 90 minutes or more per session. Large, high-quality RCTs are required to further confirm these findings.
The Energetic Saver Profile From Sit-to-Stand Does Not Persist During Very Low-Intensity Physical Activity in Healthy Men and Women
Authors: Isacco Laurie , Guirado Terry , Brun Carole , Pereira Bruno , Moore Halim , Thivel David , Duclos Martine , Metz Lore 
Published: August 2024

Background: It is essential to better characterize the energetic profile of individuals during very low-intensity physical activity. The objectives of the present study were to determine whether the saver profile from sit-to-stand persists during light physical activity and characterize patterns in substrate utilization from sit-to-stand and during very low-intensity physical activity in healthy men and women. Methods: Sixty-two healthy adults (38 women) performed an experimental sequence that corresponded to 15-minute sitting (SIT1), followed by 15-minute standing (STAND), 15-minute sitting again (SIT2), and finally 15 minutes of light cycling. Continuous indirect calorimetry was allowed to calculate energy expenditure (EE) and respiratory quotient through the entire sequence. Savers and nonsavers (<5% and ≥ 5% increase in EE from sitting to standing, respectively) were determined. Results: There was an interaction effect in EE between savers and nonsavers through the whole sequence (P = .008). Only nonsavers (71%) exhibited a significant increase in EE from SIT1 to STAND (P < .001). Nonsavers and savers significantly increased EE during 15 minutes of light cycling relative to sitting or standing (P < .001), without any difference between groups. The percentage of change in respiratory quotient from SIT1 to STAND was significantly different between the 2 groups, with increased values in savers and decreased values in nonsavers (P = .03). Significantly lower values in respiratory quotient and EE were found during 15 minutes of light cycling in women compared with men (P < .001). Conclusions: It is essential to determine individuals’ energetic phenotype to determine those who may benefit more from strategies such as standing or light physical activity. The sexual dimorphism in terms of substrate use during such exercise should be considered.
Cross-Cultural Adaptation and Validation of the German Version of the Upper Limb Functional Index
Authors: Ortega-Castillo Miguel , Cuesta-Vargas Antonio , Melloh Markus , Trinidad-Fernández Manuel 
Published: August 2024

Context: The Upper Limb Functional Index (ULFI) is a popular tool with valid psychometric properties to assess upper limb function in patients with musculoskeletal conditions. The aim of the study was to cross-culturally adapt and validate the German version of the ULFI. Design: Cross-cultural validation. Methods: A 2-stage cross-cultural adaptation of the ULFI was performed according to international guidelines through consecutive forward and backward translations. Psychometric properties of internal consistency, test–retest reliability, criterion, face and content validity, and factor structure were determined from the included German participants suffering from upper limb conditions (n = 100), who fulfilled the following inclusion criteria: (1) older than 18 years old, (2) German as native language, and (3) medical diagnosis of musculoskeletal upper limb condition. Participants completed the ULFI; Disabilities of the Arm, Shoulder, and Hand; EuroQol Health Questionnaire 5 Dimensions; and Short Form-12 questionnaires. Results: The ULFI-G showed good internal consistency (α = .88); excellent test–retest reliability (intraclass correlation coefficient2:1 = .98); directly strong correlation with Disabilities of the Arm, Shoulder, and Hand (r = .84); fair correlation with Disabilities of the Arm, Shoulder, and Hand-sport (r = .54); inversely fair correlation with EuroQol Health Questionnaire 5 Dimensions (r = −.62); and Short Form 12’s physical health domain (r = −.7). A single-factor structure was revealed. Conclusions: The ULFI-G showed adequate psychometric properties and proved to be a valid tool for upper limb functional assessment in German population.
Attentional Focus Strategies Can Improve Performance of Postural Control in Runners
Authors: Delunardo Anderson R. , Magalhães Gabriela V. , Rinaldi Natalia M. 
Published: August 2024

Attentional focus strategies, especially external focus, are associated with improvements in mechanisms of postural control. This can be important in reducing sports injuries in practices such as running, which has seen an increase in adherence. However, the impacts of these strategies on postural control in runners are unclear. This study aimed to investigate the effects of internal and external focus strategies on postural control performance with different bases of support tasks in runners. A total of 19 young adults (18–38 years old) were divided into a running group (n = 9) and a control group (n = 10). Posturography tests were performed on stable and unstable surfaces, under control, and internal and external focus conditions. The distance, mean velocity, and total velocity of the center of pressure were analyzed (p ≤ .05). There was a reduction in oscillation under external focus compared to internal and control conditions, as well as under internal focus compared to the control condition. A Group × Surface × Focus interaction for the variables distance and mean velocity in the mediolateral direction was found only for the control group. However, no significant effects were found between groups for postural control performance. Attentional focus strategies were able to reduce postural sway, with external focus condition being the most effective. Practitioners can benefit from these strategies to increase postural control performance to help reduce the number of injuries and improve sports performance. It is speculated that the effects of attentional control strategies on postural control may differ depending on the specific adaptations of each sport.
Drought-induced seismicity modulation in the New Madrid Seismic Zone, central United States
Authors: Senapati Batakrushna , Kundu Bhaskar , Jin Shuanggen , Santosh M. 
Published: August 2024

Abstract
The New Madrid Seismic Zone (NMSZ) in the central United States is a seismically active intraplate region composed of two fault segments: the Reelfoot and Cottonwood Grove fault segments. It has witnessed several major earthquakes, including a devastating 1811–1812 earthquake sequence of three ~M7 events. Nearly 200 years later, earthquakes still continue today in this complex seismic zone. This seismic zone is located in a domain with higher hydrological load than surrounding regions, which may play a crucial role in seismicity modulation. However, the hydrological unloading or loading-induced seismicity modulation and the underlying earthquake dynamics on this stable plate interior remain equivocal. Our study demonstrates that increased climate variability and drought-induced hydrological unloading can be potential drivers for the crustal stress change in the upper Mississippi embayment and seismicity modulation in the NMSZ. The seismicity rate associated with the Reelfoot fault segment shows ~60% increase during drought-induced prolonged drier periods, linked to La Niña cycles, than during the relatively wetter periods. However, such a feature is lacking for the seismicity associated with the Cottonwood Grove fault segment. We argue that the near-lithostatic pore pressure condition explicitly on the Reelfoot fault segment leads to an increase in the amplitude of the velocity perturbation, making this fault segment more susceptible to seismicity modulation on a multi-annual or annual time scale by the resonance destabilization process.
Social inequalities in the use of online food delivery services and associations with weight status: cross-sectional analysis of survey and consumer data
Authors: Cummins Steven , Kalbus Alexandra Irene , Cornelsen Laura , Adams Jean , Boyland Emma , Burgoine Thomas , Law Cherry , de Vocht Frank , White Martin , Yau Amy 
Published: August 2024

Background
Little is known about who uses online food delivery services and how use of these services is associated with social inequalities in food purchasing and diet-related health. This study explored associations between social position and use of online takeaway food and grocery delivery services, and its association with weight status.

Methods
Data were obtained from households in a consumer research panel living in London and the north of England (n=1521) in February 2019. Use of online grocery delivery services was determined via recorded purchases, and takeaway food delivery app use via survey responses. Social position was approximated through occupation-based social grade and household income. We used logistic regression to estimate the association between social position and use of online delivery services, and the relationship between online delivery service use and weight status.

Results
Overall, 13.2% of respondents used takeaway food delivery apps over a 7-day period and 15.6% of households used online grocery delivery services over a 4-week period. High-income households were more likely to use online grocery delivery services than low-income households (OR 2.01, 95% CI 1.22 to 3.34). In contrast, households with lower social grade were more likely to use takeaway food delivery apps compared with households in the highest grade (OR 2.31, 95% CI 1.38 to 3.87). While takeaway food delivery app use was positively associated with living with obesity (relative risk ratio 1.84, 95% CI 1.20 to 2.82), use of online grocery delivery services was not.

Discussion
Findings indicate that use of online food delivery services is patterned by markers of social position and weight status, which may lead to dietary inequalities. The potential impact of increased and differential usage of online delivery services on diet and dietary inequalities warrants further research.
Words matter: descriptors for nicotine that comes from tobacco and descriptors for synthetic nicotine that is created in a laboratory differentially impact understanding of nicotine source and risk perceptions
Authors: Morean Meghan Elizabeth , O'Malley Stephanie S , Krishnan-Sarin Suchitra 
Published: August 2024

Background
Nicotine products increasingly contain synthetic nicotine made in a lab (NML), not from tobacco. ‘Tobacco-free nicotine’ is most often used to describe NML commercially, but other descriptors are emerging (eg, ‘non-tobacco,’ ‘zero-tobacco’). We examined whether terms for NML differentially impact public understanding of nicotine source or risk perceptions relative to each other and to terms for describing nicotine from tobacco (NFT) as ‘tobacco-derived.’

Methods
From December 2022 to April 2023, 1000 participants aged 13 and older completed an online survey (mean age: 33.02 (SD=18.15) years, 50.5% female, 16.6% Hispanic, 67.4% White and 79.8% with current tobacco use). Participants read 11 terms describing nicotine and reported on perceived nicotine source (ie, NML, NFT) and addictiveness. Rank-ordered harm was included as a sensitivity analysis.

Results
Significant differences were observed among terms (eg, ‘zero tobacco nicotine’ and ‘no tobacco nicotine’ were rated as least addictive overall). ‘NML’ and ‘NFT’ adequately conveyed nicotine source and were rated as conveying comparable, yet high addictiveness, making them the optimal terms.

Conclusions
Many terms for NML and NFT are differentially related to understanding nicotine source and risk perceptions even though no existing research indicates that NML and NFT differ meaningfully from each other on characteristics like addictiveness. In the absence of prohibiting product differentiation by nicotine source, regulatory agencies should promote using the terms ‘Nicotine from Tobacco’ and ‘Nicotine Made in a Lab’ and investigate whether products using descriptors conveying reduced harm (eg, ‘zero-tobacco,’ ‘no-tobacco,’ ‘non-tobacco’) should require review as Modified Risk Tobacco Products.
A Dual-Payload Antibody–Drug Conjugate Targeting CD276/B7-H3 Elicits Cytotoxicity and Immune Activation in Triple-Negative Breast Cancer
Authors: Zhou Zhuoxin “Zora” , Si Yingnan , Zhang Jiashuai , Chen Kai , George Ashley , Kim Seulhee , Zhou Lufang , Liu Xiaoguang “Margaret” 
Published: August 2024

Abstract
Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous disease that often relapses following treatment with standard radiotherapies and cytotoxic chemotherapies. Combination therapies have potential for treating refractory metastatic TNBC. In this study, we aimed to develop an antibody–drug conjugate with dual payloads (DualADC) as a chemoimmunotherapy for TNBC. The overexpression of an immune checkpoint transmembrane CD276 (also known as B7-H3) was associated with angiogenesis, metastasis, and immune tolerance in more than 60% of patients with TNBC. Development of a mAb capable of targeting the extracellular domain of surface CD276 enabled delivery of payloads to tumors, and a platform was established for concurrent conjugation of a traditional cytotoxic payload and an immunoregulating Toll-like receptor 7/8 agonist to the CD276 mAb. The DualADC effectively killed multiple TNBC subtypes, significantly enhanced immune functions in the tumor microenvironment, and reduced tumor burden by up to 90% to 100% in animal studies. Single-cell RNA sequencing, multiplex cytokine analysis, and histology elucidated the impact of treatment on tumor cells and the immune landscape. This study suggests that the developed DualADC could represent a promising targeted chemoimmunotherapy for TNBC.
Significance: An anti-CD276 monoclonal antibody conjugated with both a cytotoxic drug and an immune boosting reagent effectively targets triple-negative breast cancer by inducing tumor cell death and stimulating immune cell infiltration.
Low–Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer
Authors: Li Mi , Lulla Amriti R. , Wang Yan , Tsavaschidis Spyros , Wang Fuchenchu , Karakas Cansu , Nguyen Tuyen D.T. , Bui Tuyen N. , Pina Marc A. , Chen Mei-Kuang , Mastoraki Sofia , Multani Asha S. , Fowlkes Natalie W. , Sahin Aysegul , Marshall C. Gary , Hunt Kelly K. , Keyomarsi Khandan 
Published: August 2024

Abstract
Cyclin E is a regulatory subunit of CDK2 that mediates S phase entry and progression. The cleavage of full-length cyclin E (FL-cycE) to low–molecular weight isoforms (LMW-E) dramatically alters substrate specificity, promoting G1–S cell cycle transition and accelerating mitotic exit. Approximately 70% of triple-negative breast cancers (TNBC) express LMW-E, which correlates with poor prognosis. PKMYT1 also plays an important role in mitosis by inhibiting CDK1 to block premature mitotic entry, suggesting it could be a therapeutic target in TNBC expressing LMW-E. In this study, analysis of tumor samples of patients with TNBC revealed that coexpression of LMW-E and PKMYT1-catalyzed CDK1 phosphorylation predicted poor response to neoadjuvant chemotherapy. Compared with FL-cycE, LMW-E specifically upregulates PKMYT1 expression and protein stability, thereby increasing CDK1 phosphorylation. Inhibiting PKMYT1 with the selective inhibitor RP-6306 (lunresertib) elicited LMW-E–dependent antitumor effects, accelerating premature mitotic entry, inhibiting replication fork restart, and enhancing DNA damage, chromosomal breakage, apoptosis, and replication stress. Importantly, TNBC cell line xenografts expressing LMW-E showed greater sensitivity to RP-6306 than tumors with empty vector or FL-cycE. Furthermore, RP-6306 exerted tumor suppressive effects in LMW-E transgenic murine mammary tumors and patient-derived xenografts of LMW-E–high TNBC but not in the LMW-E null models examined in parallel. Lastly, transcriptomic and immune profiling demonstrated that RP-6306 treatment induced interferon responses and T-cell infiltration in the LMW-E–high tumor microenvironment, enhancing the antitumor immune response. These findings highlight the LMW-E/PKMYT1/CDK1 regulatory axis as a promising therapeutic target in TNBC, providing the rationale for further clinical development of PKMYT1 inhibitors in this aggressive breast cancer subtype.
Significance: PKMYT1 upregulation and CDK1 phosphorylation in triple-negative breast cancer expressing low–molecular weight cyclin E leads to suboptimal responses to chemotherapy but sensitizes tumors to PKMYT1 inhibitors, proposing a personalized treatment strategy.
Enabling the Assimilation of CrIS Shortwave Infrared Observations in Global NWP at NOAA. Part II: OSEs and Results
Authors: Jones Erin , Garrett Kevin , Ide Kayo , Karpowicz Bryan , Barnet Christopher , Ma Yingtao , Boukabara Sid 
Published: August 2024

Abstract
The assimilation of data from hyperspectral infrared sounders in global data assimilation systems has historically been focused on observations in the longwave infrared (LWIR) region of the spectrum (650–1100 cm−1) despite the often concurrent availability of measurements from the shortwave infrared (SWIR) region of the spectrum (2150–2550 cm−1) because issues (like solar effects) have generally prevented the assimilation of SWIR observations. Recent advances in radiative transfer models have worked to address some of the previous challenges in simulating SWIR observations, and the assimilation of SWIR data (e.g., from potential future small-satellites) is now a feasible prospect. Still, a better understanding of how these observations perform in a data assimilation system and impact resulting analyses and NWP forecasts is necessary. In this study, the value of SWIR observations in global NWP is assessed by assimilating SWIR observations from the Cross-track Infrared Sounder (CrIS) in National Oceanic and Atmospheric Administration (NOAA)’s Global Data Assimilation System (GDAS). The methodologies used to enable the assimilation of these observations, including the implementation of a scene-dependent observation error and the enhancement of quality control procedures, are discussed, as are the results of observing system experiments (OSEs) conducted to evaluate the impact of assimilating SWIR observations on forecast skill. The overall results show that SWIR assimilation produces similar forecast impacts to LWIR assimilation. The ability to demonstrate that the assimilation or SWIR observations in NWP is a realistic prospect may help shape future constellations of small satellites to serve as a beneficial complement to the current constellation if hyperspectral infrared (IR) sounders.
Efficacy of ultrasound in the evaluation of iliac vein stenting
Authors: Clode Hannah , Spencer Elizabeth Brooke , Nelson Jacqueline , Horne Elisabeth S 
Published: August 2024

Objectives: The current study evaluated the efficacy of iliac and IVC ultrasound alone for follow-up evaluation of iliac vein stents in patients with pelvic venous disorders or iliac occlusion from chronic deep vein thrombosis. Methods: A retrospective single site cohort study was conducted by evaluating the most recent 100 iliac vein and inferior vena cava ultrasounds in patients who had undergone iliac vein stenting. Inclusion criteria included a history of iliac vein stent placement. Exclusion criteria included patients under 18-years-old, duplicates of the same patient, and pregnancy at the time of ultrasound. The degree of visualization for color flow, gray scale, and phasicity were determined and classified into the following categories: complete, partial, or none. In addition, each chart was assessed for external compression, in-stent narrowing, and requirements for further imaging. Results: Of the 100 iliac vein and IVC ultrasounds assessed in this review, 99 of the ultrasounds were sufficient for evaluation during follow-up visits without requiring further investigation. Within this study cohort, the average follow-up time was 22 months. The average participant body mass index was 27.6. One iliac vein and IVC ultrasound was considered inadequate for follow-up evaluation and required further imaging. Conclusion: The use of iliac and IVC venous doppler ultrasound alone in the follow-up evaluation of iliac stent patency is effective and noninvasive and avoids unnecessary radiation exposure and cost.