bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental test of the viscous anisotropy hypothesis for partially molten rocks
Authors: Qi Chao , Kohlstedt David L. , Katz Richard F. , Takei Yasuko 
Published: September 2015

Significance
Partially molten regions of Earth link mantle convection with surface volcanism. We present laboratory experiments and theory that are at the heart of understanding the connection between these interior and surface processes. The theory proposes that the presence of melt fundamentally changes the style of deformation, making it anisotropic with leading-order, testable consequences. The laboratory results are in agreement with theoretical predictions. These results are novel at a foundational level and profoundly surprising. Together they make the case that the creep rheology of partially molten rocks is more than the sum of its parts. Moreover, this article sets forth a framework that will guide a broad swath of future research in rock mechanics and mantle flow.
No barrier to emergence of bathyal king crabs on the Antarctic shelf
Authors: Aronson Richard B. , Smith Kathryn E. , Vos Stephanie C. , McClintock James B. , Amsler Margaret O. , Moksnes Per-Olav , Ellis Daniel S. , Kaeli Jeffrey , Singh Hanumant , Bailey John W. , Schiferl Jessica C. , van Woesik Robert , Martin Michael A. , Steffel Brittan V. , Deal Michelle E. , Lazarus Steven M. , Havenhand Jonathan N. , Swalethorp Rasmus , Kjellerup Sanne , Thatje Sven 
Published: September 2015

Significance
For tens of millions of years, cold conditions have excluded shell-crushing fish and crustaceans from the continental shelf surrounding Antarctica. Rapid warming is now allowing predatory crustaceans to return. Our study of the continental slope off the western Antarctic Peninsula showed that abundant, predatory king crabs comprise a reproductively viable population at 841- to 2,266-m depth. Depth profiles of temperature, salinity, habitat structure, food availability, and predators indicate that there are no barriers to prevent king crabs from moving upward onto the outer shelf at 400–550 m. A cold-water barrier above 200 m could be breached within the next few decades. Emergence of king crabs on the shelf could have catastrophic consequences for the unique seafloor communities of Antarctica.
The Dutch Central Sensitization Inventory (CSI)
Authors: Kregel Jeroen , Vuijk Pieter J. , Descheemaeker Filip , Keizer Doeke , van der Noord Robert , Nijs Jo , Cagnie Barbara , Meeus Mira , van Wilgen Paul 
Published: September 2015

Objectives:
A standardized assessment of central sensitization can be performed with the Central Sensitization Inventory (CSI), an English questionnaire consisting of 25 items relating to current health symptoms. The aim of this study was to translate the CSI into Dutch, to perform a factor analysis to reveal the underlying structure, examine its discriminative power, and test-retest reliability.

Methods:
The CSI was first translated into Dutch. A factor analysis was conducted on CSI data of a large group of chronic pain patients (n=368). The ability to discriminate between chronic pain patients (n=188) and pain-free controls (n=49) was determined and the test-retest reliability for chronic pain patients (n=36) and controls (n=45) with a time interval of 3 weeks was evaluated.

Results:
The exploratory factor analysis resulted in a 4-factor model based on 20 items, representing the domains “General disability and physical symptoms” (Cronbach α=0.80), “Higher central sensitivity”(Cronbach α=0.78), “Urological and dermatological symptoms”(Cronbach α=0.60), and “Emotional distress”(Cronbach α=0.80). Furthermore, a parsimonious second-order factor model was found, where the factor “General central sensitization” was underlying the 4 first-order factors. Chronic pain patients scored significantly worse on all 4 factors. The test-retest reliability was excellent values in both chronic pain patients (ICC=0.88) and controls (ICC=0.91).

Discussion:
The original CSI was translated into Dutch and did not reveal any problems during data acquisition. The domains represented by the 4 factors may be useful in setting up specific patient profiles and treatment targets. To conclude, the Dutch CSI revealed 4 distinguishable domains, showed good internal consistency for the total score and 3 out of 4 domains, good discriminative power, and excellent test-retest reliability.
Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents
Authors: Haerter Friederike , Simons Jeroen Cedric Peter , Foerster Urs , Moreno Duarte Ingrid , Diaz-Gil Daniel , Ganapati Shweta , Eikermann-Haerter Katharina , Ayata Cenk , Zhang Ben , Blobner Manfred , Isaacs Lyle , Eikermann Matthias 
Published: September 2015

AbstractAbstract
Calabadion 2 rapidly reversed deep rocuronium-, vecuronium-, and cisatracurium-induced neuromuscular blockade in a dose-dependent manner. Calabadion 2 reversed rocuronium- and vecuronium-induced neuromuscularblockade with a 1:1 binding ratio, like sugammadex, but it had a higher in vitro binding affinity and a higher molar potency in vivo.

Background
The authors evaluated the comparative effectiveness of calabadion 2 to reverse non-depolarizing neuromuscular-blocking agents (NMBAs) by binding and inactivation.

Methods
The dose–response relationship of drugs to reverse vecuronium-, rocuronium-, and cisatracurium-induced neuromuscular block (NMB) was evaluated in vitro (competition binding assays and urine analysis), ex vivo (n = 34; phrenic nerve hemidiaphragm preparation), and in vivo (n = 108; quadriceps femoris muscle of the rat). Cumulative dose–response curves of calabadions, neostigmine, or sugammadex were created ex vivo at a steady-state deep NMB. In living rats, the authors studied the dose–response relationship of the test drugs to reverse deep block under physiologic conditions, and they measured the amount of calabadion 2 excreted in the urine.

Results

In vitro experiments showed that calabadion 2 binds rocuronium with 89 times the affinity of sugammadex (Ka = 3.4 × 109 M−1 and Ka = 3.8 × 107 M−1). The results of urine analysis (proton nuclear magnetic resonance), competition binding assays, and ex vivo study obtained in the absence of metabolic deactivation are in accordance with an 1:1 binding ratio of sugammadex and calabadion 2 toward rocuronium. In living rats, calabadion 2 dose-dependently and rapidly reversed all NMBAs tested. The molar potency of calabadion 2 to reverse vecuronium and rocuronium was higher compared with that of sugammadex. Calabadion 2 was eliminated renally and did not affect blood pressure or heart rate.

Conclusions
Calabadion 2 reverses NMB induced by benzylisoquinolines and steroidal NMBAs in rats more effectively, i.e., faster than sugammadex. Calabadion 2 is eliminated in the urine and well tolerated in rats.
Microdialysis as a Part of Invasive Cerebral Monitoring During Porcine Septic Shock
Authors: Ditz Claudia , Klaus Stephan , Bahlmann Ludger , Onken Nils , Keck Alexander , Gliemroth Jan 
Published: September 2015

Background:
Metabolic changes in critically ill patients with endotoxin-induced septic shock are measured primarily by techniques that afford organ-specific metabolic monitoring based on interstitial fluid samples. The present study was designed to evaluate the role of cerebral microdialysis (MD) as a part of invasive neuromonitoring during endotoxemia in a porcine model.

Materials and Methods:
Continuous endotoxin infusion was administered to 7 female pigs and, in addition to hemodynamic monitoring and blood chemistry, interstitial lactate, pyruvate, glucose and glycerol concentrations in muscle, liver, and cerebral tissue were measured via in vivo MD for an observation period of 180 minutes.

Results:
The cerebral concentrations of lactate and glycerol showed no significant increases, whereas the hepatic and muscular levels rose dramatically under endotoxemia. However, the lactate/pyruvate ratio and especially the lactate/glucose ratio showed a profound and significant increase in brain tissue as well. Cerebral perfusion pressure decreased from 77 to 50 mm Hg without reaching pathologic values.

Conclusions:
Although our results confirm the special protection of the brain during endotoxemia compared with other organs, early metabolic changes become evident by increasing lactate/pyruvate ratio and lactate/glucose ratio. MD appears to be a suitable additional technique in invasive neuromonitoring for obtaining early information about metabolic deterioration in the brain during septic shock.
Pretransfusion Comparison of Dialyser-Based Hemoconcentrator with Cell Saver System for Perioperative Cell Salvage
Authors: Garg Pankaj , Malhotra Amber , Desai Manan , Sharma Pranav , Bishnoi Arvind Kumar , Tripathi Payal , Rodricks Dayesh , Pandya Himani 
Published: September 2015

Objective Cell Saver system is the method of choice for red blood cell salvage from the surgical field; however, cost is a limiting factor. We at our institute have devised a cost-effective version of dialyser-based autotransfusion system. We performed pretransfusion comparison of our autotransfusion system with conventional cell saver system. Methods A prospective randomized observational study was performed in 104 consecutive patients with coronary artery disease undergoing by off-pump coronary artery bypass grafting. Patients were divided into two groups. In the dialyser group (53 patients), blood from surgical field was salvaged by our dialyser-based system. In the cell saver group (51 patients), blood was salvaged by cell saver. In both groups, 20-mL sample from the salvaged blood was analyzed for hemoglobin, platelets, protein, albumin, free hemoglobin, osmotic fragility, and peripheral blood smear examination. Results Total hemoglobin salvaged was comparable in both groups (85% vs 76%). On peripheral smear, red blood cells were swollen, but morphology was preserved. Moreover, normal osmotic fragility suggested absence of any lethal damage to red blood cells in either group. Dialyser-based system was more efficient in salvaging platelets (42.9% vs 6%), proteins (79.2% vs 0%), and albumin (65% vs 0%). Total free hemoglobin was three times more in dialyser group but was well below recommended limits. Conclusions Dialyser-based system is economical, is equally efficacious in salvaging red blood cells, is more effective in salvaging platelets and proteins, and does not contain significant amount of free hemoglobin. Therefore, this salvaged blood can be safely transfused.
Attrition in Long‐Term Nutrition Research Studies
Authors: Fewtrell Mary S. , Domellöf Magnus , Hojsak Iva , Hulst Jessie M. , Kennedy Kathy , Koletzko Berthold , Mihatsh Walter , Stijnen Theo 
Published: September 2015

ABSTRACTLong‐term follow‐up of randomised trials and observational studies provide the best evidence presently available to assess long‐term effects of nutrition, and such studies are an important component in determining optimal infant feeding practices. Attrition is, however, an almost inevitable occurrence with increasing age at follow‐up. There is a common assumption that studies with <80% follow‐up rates are invalid or flawed, and this criticism seems to be more frequently applied to follow‐up studies involving randomised trials than observational studies. In this article, we explore the basis and evidence for this “80% rule” and discuss the need for greater consensus and clear guidelines for analysing and reporting results in this specific situation.
Bullying and Suicide Risk Among Pediatric Emergency Department Patients
Authors: Stanley Ian H. , Horowitz Lisa M. , Bridge Jeffrey A. , Wharff Elizabeth A. , Pao Maryland , Teach Stephen J. 
Published: September 2015

Objectives
This study aimed to describe the association between recent bullying victimization and risk of suicide among pediatric emergency department (ED) patients.

Methods
Patients presenting to 1 of 3 different urban pediatric EDs with either medical/surgical or psychiatric chief complaints completed structured interviews as part of a study to develop a suicide risk screening instrument, the Ask Suicide-Screening Questions. Seventeen candidate items and the criterion reference Suicidal Ideation Questionnaire were administered to patients ages 10 to 21 years. Bullying victimization was assessed by a single candidate item (“In the past few weeks, have you been bullied or picked on so much that you felt like you couldn't stand it anymore?”).

Results
A total of 524 patients completed the interview (34.4% psychiatric chief complaints; 56.9% female; 50.4% white, non-Hispanic; mean [SD] age, 15.2 [2.6] years). Sixty patients (11.5%) reported recent bullying victimization, and of these, 33 (55.0%) screened positive for suicide risk on the Ask Suicide-Screening Questions or the previously validated Suicidal Ideation Questionnaire. After controlling for demographic and clinical variables, including a history of depression and drug use, the odds of screening positive for suicide risk were significantly greater in patients who reported recent bullying victimization (adjusted odds ratio, 3.19; 95% confidence interval, 1.66–6.11). After stratification by chief complaint, this association persisted for medical/surgical patients but not for psychiatric patients.

Conclusions
Recent bullying victimization was associated with increased odds of screening positive for elevated suicide risk among pediatric ED patients presenting with medical/surgical complaints. Understanding this important correlate of suicide risk in pediatric ED patients may help inform ED-based suicide prevention interventions.
An Option Space for Early Neural Evolution
Authors: Jékely Gáspár , Keijzer Fred , Godfrey Smith Peter 
Published: September 2015

SummaryThe origin of nervous systems has traditionally been discussed within two conceptual frameworks. Input-output models stress the sensory-motor aspects of nervous systems, while internal coordination models emphasize the role of nervous systems in coordinating multicellular activity, especially muscle-based motility. Here we consider both frameworks and apply them to describe aspects of each of three main groups of phenomena that nervous systems control: behavior, physiology and development. We argue that both frameworks and all three aspects of nervous system function need to be considered for a comprehensive discussion of nervous system origins. This broad mapping of the option space enables an overview of the many influences and constraints that may have played a role in the evolution of the first nervous systems.
MG7: Configurable and scalable 16S metagenomics data analysis
Authors: Alekhin Alexey , Kovach Evdokim , Manrique Marina , Pareja-Tobes Pablo , Pareja Eduardo , Tobes Raquel , Pareja-Tobes Eduardo 
Published: September 2015

AbstractAs part of the Cambrian explosion of omics data, metagenomics brings to the table a specific, defining trait: its social essence. Themetaprefix exerts its influence, with multitudes manifesting themselves everywhere; from samples to data analysis, from actors involved to (present and future) applications. Of these dimensions, data analysis is where needs lay further from what current tools provide. Key features are, among others, scalability, reproducibility, data provenance and distribution, process identity and versioning. These are the goals guiding our work in MG7, a 16S metagenomics data analysis system. The basic principle is a new approach to data analysis, where configuration, processes, or data locations are static, type-checked and subject to the standard evolution of a well-maintained software project. Cloud computing, in its Amazon Web Services incarnation, when coupled with these ideas, produces a robust, safely configurable, scalable tool. Processes, data, machine behaviors and their dependencies are expressed using a set of libraries which bring as much as possible checking and validation to the type level, without sacrificing expressiveness. Together they form a toolkit for defining scalable cloud-based workflows composed of stateless computations, with a static reproducible specification of dependencies, behavior and wiring of all steps. The modeling of taxonomy data is done using Bio4j, where the new paradigm of graph databases allows for both a simple expression of taxonomic assignment tasks and the calculation of taxa abundance values considering the hierarchic structure of the taxonomy tree. MG7 includes a new 16S reference database,16S-DB7, built with a flexible and sustainable update system, and the possibility of project-driven personalization.
The effect of knowledge management on environmental innovation
Authors: Stanovcic Tatjana , Pekovic Sanja , Bouziri Amira 
Published: September 2015

Purpose– The purpose of this paper is to analyze whether knowledge management (KM) practices trigger environmental innovation. Additionally, distinguishing between two types of KM practices, the authors want to examine whether different types of KM practices have the same role for environmental innovation.Design/methodology/approach– Employing two French surveys, namely, the Community Innovation Survey (2002-2004 and 2006-2008) and Annual Firm Survey (EAE, 2000), the authors analyze empirically the relationship between KM practices and environmental innovation. The theoretical relationship the authors propose is tested using bivariate probit model on 1,117 French manufacturing firms.Findings– The econometric estimations show that the investment in KM practices trigger environmental innovation. Furthermore, the authors distinguish between two types of KM practices: a written policy of KM and a culture intended to promote KM sharing. The main results are also confirmed for both types of KM practices. Moreover, based on coefficients and significance levels, the empirical results indicate that a culture intended to promote KM sharing has a more substantial impact on green innovation than a written policy of KM.Practical implications– KM can boost environmental innovation, which also enhances firm business performance. Therefore, managers should foster investment in KM capabilities. They need to create working atmosphere that generates, stores, transfers and applies knowledge in order to improve a firm’s green innovativeness. Additionally, the study results show that managers can choose among different KM practices in order to enhance environmental innovation. However, managers should be aware that not all KM practices provide the full advantage in terms of performance improvement. They should know that different KM practices have differential impacts on different performance outcomes. In this sense, managers should implement KM practices that fit their performance strategy.Originality/value– The relationship between KM and innovation performance has received increasing attention from researchers during the past years. However, even though scholars underline the importance of environmental innovation, the relationship between KM and environmental innovation remains significantly under-researched. The findings suggest that KM should be considered as an important source for environmental innovation improvement.
Exploring the role of knowledge management practices in fostering customer relationship management as a catalyst of marketing innovation
Authors: Garrido-Moreno Aurora , Lockett Nigel , Garcia-Morales Victor 
Published: September 2015

Purpose– The purpose of this paper is to propose a research model exploring the link between knowledge management processes and customer relationship management (CRM) performance. It seeks to answer two research questions: What are the effective drivers of knowledge management processes in the context of a CRM initiative? Do these processes make a real impact on CRM performance?Design/methodology/approach– The paper is based on data obtained from a sample of 93 service companies located in Spain. The authors conducted a structural equation modeling analysis using PLS to test the proposed hypotheses.Findings– It was observed that both technological and organizational readiness were effective drivers of knowledge management. However, it was contrasted also that the usage of social media tools was not significantly related to knowledge management. Results show a real impact of knowledge management processes on CRM performance, so companies can understand how to implement successfully those initiatives.Research limitations/implications– The main limitations of the study are that it was based on cross-sectional data and that variables were measured based on the perceptions of general managers.Practical implications– Service companies need to invest in technological infrastructures, and create an appropriate organizational climate (top management support, employees commitment) in order to promote effective knowledge management processes, that will enable CRM success, paving the way for the development of marketing innovations.Originality/value– This is the first empirical work that examines in confirmatory way what are the main drivers of knowledge management processes, including in the analysis the impact of both organizational and technological readiness, and considering also the usage of social media tools, in the context of a CRM initiative.
Knowledge management practices and innovation performance in Finland
Authors: Inkinen Henri Tapio , Kianto Aino , Vanhala Mika 
Published: September 2015

Purpose– Recent empirical studies have suggested that knowledge-based issues are closely related to companies’ innovation performance. However, the majority of research seems to be focused either on static knowledge assets or knowledge processes such as knowledge creation. The purpose of this paper is to concentrate on the conscious and systematic managerial activities for dealing with knowledge in firms (i.e. knowledge management (KM) practices), which aim at innovation performance improvements through proactive management of knowledge assets. The study explores the impact that KM practices have on innovation performance.Design/methodology/approach– The authors provide empirical evidence on how various KM practices influence innovation performance. The results are based on survey data collected in Finland during fall 2013. The authors use partial least squares to test the hypothesized relationships between KM practices and innovation performance.Findings– The authors find that firms are capable of supporting innovation performance through strategic management of knowledge and competence, knowledge-based compensation practices, and information technology practices. The authors also point out that some of the studied KM practices are not directly associated with innovation performance.Originality/value– This study adds to the knowledge-based view of the firm by demonstrating the significance of the management of knowledge for innovation performance. Furthermore, the division of KM practices into ten types and the provision of the validated scales for measuring these add to the general understanding of KM as a field of theory and practice. This study is valuable also from managerial perspective, as it sheds light on the potentially most effective KM practices to improve companies’ innovation performance.