bluuebunny/crossref_metadata_2025_split huggingface dataset:
ALK5/VEGFR2 dual inhibitor TU2218 alone or in combination with immune checkpoint inhibitors enhances immune-mediated antitumor effects
Authors: Kim Nam-Hoon , Lee Jihyun , Kim Seung-Hyun , Kang Seong-Ho , Bae Sowon , Yu Chan-Hee , Seo Jeongmin , Kim Hun-Taek 
Published: August 2024

AbstractTransforming growth factor β (TGFβ) is present in blood of patients who do not respond to anti-programmed cell death (ligand) 1 [PD-(L)1] treatment, and through synergy with vascular endothelial growth factor (VEGF), it helps to create an environment that promotes tumor immune evasion and immune tolerance. Therefore, simultaneous inhibition of TGFβ/VEGF is more effective than targeting TGFβ alone. In this study, the dual inhibitory mechanism of TU2218 was identified through in vitro analysis mimicking the tumor microenvironment, and its antitumor effects were analyzed using mouse syngeneic tumor models. TU2218 directly restored the activity of damaged cytotoxic T lymphocytes (CTLs) and natural killer cells inhibited by TGFβ and suppressed the activity and viability of regulatory T cells. The inactivation of endothelial cells induced by VEGF stimulation was completely ameliorated by TU2218, an effect not observed with vactosertib, which inhibits only TGFβ signaling. The combination of TU2218 and anti-PD1 therapy had a significantly greater antitumor effect than either drug alone in the poorly immunogenic B16F10 syngeneic tumor model. The mechanism of tumor reduction was confirmed by flow cytometry, which showed upregulated VCAM-1 expression in vascular cells and increased influx of CD8 + CTLs into the tumor. As another strategy, combination of anti-CTLA4 therapy and TU2218 resulted in high complete regression (CR) rates in CT26 and WEHI-164 tumor models. In particular, immunological memory generated by the combination of anti-CTLA4 and TU2218 in the CT26 model prevented the development of tumors after additional tumor cell transplantation, suggesting that the TU2218-based combination has therapeutic potential in immunotherapy.
Swimming in viscoplastic fluids
Authors: Hewitt Duncan R. 
Published: August 2024

Abstract
Locomotion at small scales in the absence of inertia is a classical and enduring research topic. Here, recent developments in the theory of such locomotion through a viscoplastic ambient fluid are reviewed and explored. The specific focus here applies to motion of cylindrical filamentary bodies that are long and thin, for which an asymptotic slender-body theory can be exploited. Details of this theory are summarised and then applied to describe different swimming waveforms: undulation, peristalsis, and helical motion. It is shown that, in general, strong force anisotropy close to the limit of axial cylindrical motion has a significant effect on locomotion in viscoplastic media, allowing for highly efficient motion in which the swimmer is able to ‘cut’ through the material following very closely the path of its own axis. Some qualitative comparison with experiments is presented, and future extensions and research directions are reviewed.

Graphical abstract
Deformation fields around cylinders moving at different angles to their axis through a yield stress fluid, showing (a) a low yield stress and (b) a high yield stress
Stem revision vs. internal fixation in Vancouver B2/B3 periprosthetic hip fractures: systematic review and metanalysis
Authors: Di Martino Alberto , Brunello Matteo , Villari Eleonora , D’Agostino Claudio , Cosentino Monica , Bordini Barbara , Rivera Fabrizio , Faldini Cesare 
Published: August 2024

Abstract
Introduction
Vancouver B2 and B3 periprosthetic fractures (PFF) are associated with stem instability and often require a demanding stem implant revision (SR) or internal fixation (ORIF). This latter surgery is increasingly performed in the last few years instead of SR, but it is unclear which is the best treatment to manage PFF patients. The aim of this study is the compare the outcomes of B2/B3 PFF managed by either ORIF or SR, by performing a systematic review and meta-analysis of current literature.

Materials and methods
Cochrane Database, PubMed, Google Scholar and MEDLINE were examined to find out relevant publications dealing with the different outcomes of SR vs. ORIF in B2/B3 PFF of the hip. The effect model (EM) was calculated using Cohen´s d index.

Results
Fifteen studies were included, reporting on a total of 1629 patients (564 ORIF and 1065 SR). The pooled random EM estimates for reoperation was 0.87 (95% CI, 0.39–1.96; I2 = 78%) in favor of ORIF surgery; EM for complications was 1.01 (95% CI, 0.45–2.27; I2 = 85%) without difference among procedures. The EM for transfusion was 0.72 (95% CI, 0.46–1.12; I2 = 62%) in favor of fixation.

Conclusion
ORIF and SR were both suitable and effective options in PFF patients, being associated to similar complications rates. Our results show that ORIF performance in PFF patients is associated to significantly less in blood loss, surgical time and in-hospital stay. These advantages are particularly appealing in patients with multiple comorbidities.
Labor market effects of rehabilitation for patients diagnosed with dizziness – a Danish nationwide register-based cohort study
Authors: Tønnesen Emil Severin , Nielsen Jesper Bo , Rose Kim , Wanscher Jens Højberg , Schmidt Jesper Hvass , Sorensen Jesper Roed 
Published: August 2024

Abstract
Purpose
Both vestibular neuronitis (VN) and Meniere’s disease (MD) have great impact on quality of life and are associated with a significant number of sick leave days absent from work. The aim was to assess labor market participation rate one year after hospital diagnosis of VN and MD and the use of rehabilitation measures.

Study design
Nationwide register-based cohort study including patients with VN (n = 1,341) and MD (n = 843) and control persons matched in 1:5 with a VN cohort control (n = 6,683) and MD cohort control (n = 4,209).

Results
Compared to control persons, VN patients were more likely to be single, have higher income, and a higher Charlson comorbidity index score. MD patients had a higher level of education and a higher Charlson index compared to control persons. One year after patients were diagnosed with VN, no significant difference in labor market participation was observed (p = 0.88). However, MD patients had a 10.4% reduced probability of possessing a full-time job one year after diagnosis compared to matched control persons (58.1 ± 0.5% vs. 68.5 ± 0.5%, p < 0.001). Both VN and MD patients consulted otorhinolaryngologists, general practitioners, and physiotherapists more than control persons both before and after the initial diagnosis (p < 0.01). In addition, MD patients also consulted psychologists more frequently before and after diagnosis of the disease (p < 0.01).

Conclusion
Intrahospital diagnosed MD increases the risk of leaving the labor market in opposition to VN. Both MD and VN are associated with significant expenses to the Danish health care system from the use of public rehabilitation measures and medical consultations.
Bone conducted cervical vestibular evoked myogenic potentials: comparison of tone burst stimulus vs chirp stimulus
Authors: Karaçaylı Ceren , Karababa Ercan , Satar Bülent 
Published: August 2024

Abstract
Purpose
Vestibular evoked myogenic potential (VEMP) is a test used to evaluate the function of otolith organs. In healthy individuals, air-conducted (AC) responses are obtained, whereas, in conductive hearing loss, the inability to transmit the signal well enough with AC stimuli has led to the need for bone-conducted (BC) stimuli. This study aimed to compare 500 Hz Chirp and Tone Burst stimuli in terms of latency and amplitude in BC cVEMP.

Methods
This prospective observational case control study included 35 healthy participants (70 ears) between the age of 20–50. Participants underwent VEMP testing with BC 500 Hz Tone Burst stimulus and 500 Hz narrow band Chirp stimulus without changing the position of the bone conducted vibrator. The intensity of the stimuli was 50 dB nHL.

Results
Response rate of 500 Hz TB Stimulus was 51.4% and 95.7% in Chirp stimulus. It was observed that significantly more responses were obtained with Chirp stimulus than TB stimulus (p < 0.001). In terms of p1 latency, n1 latency, both latencies were significantly shorter in Chirp stimulus (p < 0.001). p1n1 amplitude was found significantly larger in Chirp stimulus (p < 0.001).

Conclusion
Compared to 500 Hz TB stimulus, 500 Hz Chirp stimulus results in a higher response rate, larger p1n1 amplitude, and shorter p1 and n1 latency. A higher response rate may provide a more accurate assessment of otolith organs, reducing false negatives due to signal transmission in patients.
Weights for moments’ geometrical localization: a canonical isomorphism
Authors: Alonso Rodríguez Ana , Camaño Jessika , De Los Santos Eduardo , Rapetti Francesca 
Published: August 2024

AbstractThis paper deals with high order Whitney forms. We define a canonical isomorphism between two sets of degrees of freedom. This allows to geometrically localize the classical degrees of freedom, the moments, over the elements of a simplicial mesh. With such a localization, it is thus possible to associate, even with moments, a graph structure relating a field with its potential.
Relative risk aversion must be close to 1
Authors: Levy Moshe 
Published: August 2024

AbstractAny utility function that is unbounded either from below or from above implies paradoxical behavior. However, these paradoxes may be regarded as irrelevant if they involve wealth levels that are realistically meaningless. Employing real-world constraints on wealth reveals that CRRA utility with relative risk aversion outside of the range 0.75–1.15 yields paradoxical choices that very few individuals, if any, would ever make. Thus, relative risk aversion must be close to 1, the value corresponding to log preferences. These results shed new light on the longstanding debate about the geometric-mean criterion and the argument of stocks for the long-run.
Factors influencing seasonal chemistry patterns in Virginia mountain streams
Authors: Riscassi Ami L. , Scanlon Todd M. , Galloway James N. 
Published: August 2024

AbstractThe relative influence of seasonal patterns in hydrological flow and seasonal differences in biological and geochemical activity on stream chemistry patterns is difficult to discern because they covary; temperate systems are characterized by lower mean flow in the summer (i.e. corresponding to deeper flow paths, elevated temperature, and biological activity), and higher mean flow in the winter (i.e. corresponding to shallower flow paths, depressed temperature, and biological dormancy). Using 2018 data, when seasonal stream flow conditions reversed, and two prior conventional water years, the relationship between monthly acid-relevant analyte concentrations and streamflow were compared within and between winter and summer to provide insight into controls on characteristic seasonal chemistry patterns at two mid-Appalachian sites with distinct geology (weatherable mafic and weather resistant siliciclastic). Acid neutralizing capacity (ANC) increased (1) with lower flow, in both seasons and (2) in summer, for all flow conditions. The compounding impacts resulted in a doubling of concentration from typical winter with high flow to summer with low flow at both sites. Base cation patterns tracked ANC at the mafic site, resulting in an ~ 60% increase of from winter with high flow to summer with low flow; distinctions between summer and winter contributed more to the seasonal pattern (72%) than changes in flow. Sulfate increased at the mafic site (1) with higher flow, in both seasons and (2) in winter, for all flow conditions, resulting in an ~ 50% increase from summer with low flow to winter with high flow; distinctions between winter and summer conditions and flow contributed similarly (40–60%) to the typical seasonal chemical pattern. The biogeochemical mechanism driving differences in stream chemistry between summer and winter for the same flow conditions is likely increased rates of natural acidification from elevated soil respiration in summer, resulting in greater bedrock weathering and sulfate adsorption. Findings highlight the significance and consistency of growing vs dormant season variations in temperature and biological activity in driving intra-annual patterns of stream solutes. This data set informs parameterization of hydro-biogeochemical models of stream chemistry in a changing climate at a biologically relevant, seasonal, timescale.
Alterations in the expression of homologous recombination repair (HRR) genes in breast cancer tissues considering germline BRCA1/2 mutation status
Authors: Laczmanska Izabela , Matkowski Rafal , Supplitt Stanislaw , Karpinski Pawel , Abrahamowska Mariola , Laczmanski Lukasz , Maciejczyk Adam , Czykalko Ewelina , Iwaneczko Ewelina , Kasprzak Piotr , Szynglarewicz Bartłomiej , Sasiadek Maria 
Published: August 2024

Abstract
Introduction
Homologous recombination (HR) is a crucial DNA-repair mechanism, and its disruption can lead to the accumulation of mutations that initiate and promote cancer formation. The key HR genes, BRCA1 and BRCA2, are particularly significant as their germline pathogenic variants are associated with a hereditary predisposition to breast and/or ovarian cancer.

Materials and methods
The study was performed on 45 FFPE breast cancer tissues obtained from 24 and 21 patients, with and without the germline BRCA1/2 mutation, respectively. The expression of 11 genes: BRCA1, BRCA2, ATM, BARD1, FANCA, FANCB, FANCI, RAD50, RAD51D, BRIP1, and CHEK2 was assessed using Custom RT2 PCR Array (Qiagen), and results were analysed using R.

Results
Cancer tissues from patients with BRCA1 or BRCA2 germline mutations displayed no significant differences in the expression of the selected HR genes compared to BRCA1 or BRCA2 wild-type cancer tissues. In BRCA1mut cancer tissues, BRCA1 expression was significantly higher than in BRCA2mut and BRCA wild-type cancer tissues.

Conclusions
In cancer tissues harbouring either BRCA1 or BRCA2 germline mutations, no significant differences in expression were observed at the mRNA level of any tested HR genes, except BRCA1. However, the significant differences observed in BRCA1 expression between germline BRCA1mut, germline BRCA2mut and BRCA1/2wt tissues may indicate a compensatory mechanism at the mRNA level to mitigate the loss of BRCA1 function in the cells.
Engaging students in higher education with educational technology
Authors: Godsk Mikkel , Møller Karen Louise 
Published: August 2024

AbstractThere is a widespread agenda of improving teaching and learning in higher education by engaging students with educational technology. Based on a large-scale literature review, the article presents 61 specific, research-based recommendations for realising the engagement potential of eight types of educational technologies in higher education. These recommendations can be used, for example, by educators to incorporate specific, available educational technologies into their teaching or as an educational development method to enhance particular forms of student engagement. Based on the evidence, the article points out that some educational technologies have a more documented and sometimes also broader potential to engage the students behaviourally, affectively, and/or cognitively than others and that this likely is related to the extent the technology supports structure, active learning, communication, interaction, and activities on the higher levels on the learning taxonomies.
Artificial intelligence applications in education: Natural language processing in detecting misconceptions
Authors: Kökver Yunus , Pektaş Hüseyin Miraç , Çelik Harun 
Published: August 2024

AbstractThis study aims to determine the misconceptions of teacher candidates about the greenhouse effect concept by using Artificial Intelligence (AI) algorithm instead of human experts. The Knowledge Discovery from Data (KDD) process model was preferred in the study where the Analyse, Design, Develop, Implement, Evaluate (ADDIE) instructional design cycle was used. The dataset obtained from 402 teacher candidates was analysed by Natural Language Processing (NLP) methods. Data was classified using Machine Learning (ML), one of the AI tools, and supervised learning algorithms. It was concluded that 175 teacher candidates did not have sufficient knowledge about the concept of greenhouse effect. It was found that the AI algorithm with the highest accuracy rate and used to predict teacher candidates’ misconceptions was Multilayer Perceptron (MLP). Furthermore, through the Enhanced Ensemble Model Architecture developed by researchers, the combination of ML algorithms has achieved the highest accuracy rate. The kappa (κ) value was examined in determining the significant difference between the AI algorithm and the human expert evaluation, and it was found that there was a significant difference, and the strength of agreement was significant according to the research findings. The findings of the current study represent a significant alternative to the prevailing pedagogical approach, which has increasingly come to rely on information technologies in the process of improving conceptual understanding through the detection of conceptual misconceptions. In addition, recommendations were made for future studies.
Foreign Direct Investment and Technology Licensing in a Polluting Industry
Authors: Cao Jiyun , Mukherjee Arijit 
Published: August 2024

AbstractWe consider a firm’s incentive for foreign direct investment (FDI) and international technology licensing in a polluting industry. We explain the rationale and the welfare implications of complementarity between FDI and licensing, i.e., the firm’s strategy of “FDI and licensing” (FL), which is empirically relevant but ignored in the literature. When the environmental tax cannot be committed, the firm adopts the licensing strategy if the pollution intensity is not high, and the licensing strategy may create lower consumer surplus and welfare compared to both FDI and FL. However, if the pollution intensity is high, the firm undertakes FL, which provide higher consumer surplus and welfare compared to both licensing and FDI. When the government can commit to the environmental tax, the firm always prefers FL. The host-country welfare is higher but the consumer surplus and world welfare may be lower under the committed tax policy compared to the non-committed tax policy. These results hold under Cournot competition and Stackelberg competition. We further show that FL can be the equilibrium strategy of the foreign firm if there is fixed-fee licensing instead of a two-part tariff licensing, which is considered in the main analysis.
Green Innovation and Energy Efficiency: Moderating Effect of Institutional Quality Based on the Threshold Model
Authors: Chen Chaoyi , Pinar Mehmet , Román-Collado Rocío 
Published: August 2024

AbstractRecent studies demonstrated that green innovation and environment-related technologies reduce energy intensity and improve energy efficiency, contributing to the reduction of carbon emissions. However, the existing studies employ linear estimation methods to examine the relationship between green innovation and energy intensity and do not consider the indirect implications of institutional quality for the effect of green technology on energy intensity. Institutional quality is found to be an essential driver of innovation, and countries may need to achieve at least a minimum level of institutional quality to promote green innovation and improve their energy intensity. To test this hypothesis, this paper examines the relationship between energy intensity and green innovation using a panel dataset from 72 countries between 1996 and 2017 and a panel threshold model when institutional quality is considered a threshold variable. The findings highlight that green innovation reduces the energy intensity if and only if countries surpass a certain threshold of institutional quality. Therefore, countries need to improve their institutional quality to promote green innovation and benefit from green technologies in improving their energy intensity.
The algebraic learning of middle school students’ evolution during a school year: a statistical large-scale study based on results in mathematics didactics
Authors: Grugeon-Allys Brigitte , Pilet Julia 
Published: August 2024

AbstractThis large-scale study characterizes the algebraic learning of a cohort of nearly 800 French students during the last year of middle school (9th grade, 14–15 years old) and examines their evolution in relation to the composition of the classes to which the students belong. Based on the Anthropological Theory of the Didactic (ATD), the study is founded both on a reference model of elementary algebra and on technological-theoretical levels characterizing the students’ reasoning and their knowledge regarding institutional expectations. These are used to code the data and define the statistical variables on which multivariate descriptive analyses are carried out. Students’ learning is analyzed through Pépite, an algebra test given at the beginning and at the end of the year. A cluster analysis resulted in three distinct clusters of similar classes and of similar students both at the beginning and end of the grade 9 school year. They are interpreted didactically and could be useful for a teacher who has to manage the heterogeneity of learning in a class. Some classes and students move from one cluster to another between the beginning and the end of the year, showing a wide variety of ways in which students’ algebra learning progresses or regresses over a school year.
Vocal differences in note, sequence and great call sequence among three closely related Nomascus gibbon species
Authors: Han Pu , Ma Hai-gang , Wang Zi-di , Fan Peng-lai , Fan Peng-fei 
Published: August 2024

Abstract
The vocal structure of gibbons has long been believed to be under strong genetic control and consistent with phylogeny. Gibbon vocalizations show hierarchical structures and song coordination behaviors, which may have different functions and convey distinct information compared to basic notes. However, previous studies have not compared vocalizations at multiple levels across species. We compared the vocal structures of three Nomascus species in the wild in South China, namely the western black gibbon (Nomascus concolor), Cao vit gibbon (N. nasutus), and Hainan gibbon (N. hainanus) at the levels of note (six features of four types of notes), male sequence (eight features), and song coordination (four features of the overlap pattern between male and female songs). We selected 15 recordings for each species: N. concolor (six groups, 2006 to 2021), N. nasutus (seven groups, 2008 to 2021), and N. hainanus (six groups, 2020 to 2021). We used permuted random forest analysis to test for species differences in vocal structure and the contribution of acoustic features to species differences at each level. We used acoustic features to construct a hierarchical clustering tree, and compared it with phylogenetic relationships. We found significant differences at all levels except the boom note. Acoustic similarity did not match genetic similarity in boom and pre-modulated notes, suggesting that genetic differences are not the only factor leading to species differences in vocal structures. We also found different contributions of acoustic features to differentiation in vocal structure at different levels. Our study suggests that we need to compare gibbon vocalizations at different levels to understand their differentiation and evolution.