bluuebunny/crossref_metadata_2025_split huggingface dataset:
The origin of young mare basalts inferred from lunar meteorites Northwest Africa 4734, 032, and LaPaz Icefield 02205
Authors: Elardo Stephen M. , Shearer Charles K. , Fagan Amy L. , Borg Lars E. , Gaffney Amy M. , Burger Paul V. , Neal Clive R. , Fernandes Vera A. , McCubbin Francis M. 
Published: January 2014

AbstractNorthwest Africa (NWA) 4734 is an unbrecciated basaltic lunar meteorite that is nearly identical in chemical composition to basaltic lunar meteoritesNWA032 and LaPaz Icefield (LAP) 02205. We have conducted a geochemical, petrologic, mineralogic, and Sm‐Nd, Rb‐Sr, and Ar‐Ar isotopic study of these meteorites to constrain their petrologic relationships and the origin of young mare basalts.NWA4734 is a low‐Ti mare basalt with a low Mg* (36.5) and elevated abundances of incompatible trace elements (e.g., 2.00 ppm Th). The Sm‐Nd isotope system datesNWA4734 with an isochron age of 3024 ± 27 Ma, an initial εNdof +0.88 ± 0.20, and a source region147Sm/144Nd of 0.201 ± 0.001. The crystallization age ofNWA4734 is concordant with those ofLAP02205 andNWA032.NWA4734 andLAP02205 have very similar bulk compositions, mineral compositions, textures, and ages. Their source region147Sm/144Nd values indicate that they are derived from similar, but distinct, source materials. They probably do not sample the same lava flow, but rather are similarly sourced, but isotopically distinct, lavas that probably originate from the same volcanic complex. They may have experienced slightly different assimilation histories in route to eruption, but can be source‐crater paired.NWA032 remains enigmatic, as its source region147Sm/144Nd definitively precludes a simple relationship withNWA4734 andLAP02205, despite a similar bulk composition. Their high Ti/Sm, low (La/Yb)N, and Cl‐poor apatite compositions rule out the direct involvement ofKREEP. Rather, they are consistent with low‐degree partial melting of late‐formedLMOcumulates, and indicate that the geochemical characteristics attributed to urKREEPare not unique to that reservoir. These and other basaltic meteorites indicate that the youngest mare basalts originate from multiple sources, and suggest thatKREEPis not a prerequisite for the most recent known melting in the Moon.
Striga hermonthica MAX2 restores branching but not the Very Low Fluence Response in the Arabidopsis thaliana max2 mutant
Authors: Liu Qing , Zhang Yanxia , Matusova Radoslava , Charnikhova Tatsiana , Amini Maryam , Jamil Muhammad , Fernandez‐Aparicio Monica , Huang Kan , Timko Michael P. , Westwood James H. , Ruyter‐Spira Carolien , van der Krol Sander , Bouwmeester Harro J. 
Published: January 2014

Summary

Seed germination of Striga spp. (witchweeds), one of the world's most destructive parasitic weeds, cannot be induced by light but is specifically induced by strigolactones. It is not known whether Striga uses the same components for strigolactone signaling as host plants, whether it has endogenous strigolactone biosynthesis and whether there is post‐germination strigolactone signaling in Striga.

Strigolactones could not be detected in in vitro grown Striga, while for host‐grown Striga, the strigolactone profile is dominated by a subset of the strigolactones present in the host.

Branching of in vitro grown Striga is affected by strigolactone biosynthesis inhibitors. ShMAX2, the Striga ortholog of Arabidopsis MORE AXILLARY BRANCHING 2 (AtMAX2) – which mediates strigolactone signaling – complements several of the Arabidopsis max2‐1 phenotypes, including the root and shoot phenotype, the High Irradiance Response and the response to strigolactones. Seed germination of max2‐1 complemented with ShMAX2 showed no complementation of the Very Low Fluence Response phenotype of max2‐1.

Results provide indirect evidence for ShMAX2 functions in Striga. A putative role of ShMAX2 in strigolactone‐dependent seed germination of Striga is discussed.
The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana
Authors: Eckert Christian , Offenborn Jan Niklas , Heinz Tobias , Armarego‐Marriott Tegan , Schültke Stefanie , Zhang Chunxia , Hillmer Stefan , Heilmann Mareike , Schumacher Karin , Bock Ralph , Heilmann Ingo , Kudla Jörg 
Published: January 2014

SummaryStimulus‐specific calcium (Ca2+) signals have crucial functions in developmental processes in many organisms, and are deciphered by various Ca2+‐binding proteins. In Arabidopsis thaliana, a signaling network consisting of calcineurin B‐like (CBL) protein calcium sensors and CBL‐interacting protein kinases (CIPKs) has been shown to fulfil pivotal functions at the plasma membrane in regulating ion fluxes and abiotic stress responses. However, the role of tonoplast‐localized CBL proteins and especially their function in regulating developmental programs remains largely unknown. In this study, we analyzed single and double mutants of the closely related tonoplast‐localized calcium sensors CBL2 and CBL3, which show either reduction of function (rf) or complete loss of function (lf). While single cbl2 or cbl3 mutants did not display discernable phenotypes, cbl2/cbl3 mutants exhibited defects in vegetative growth and were severely impaired in seed development and morphology. Seeds of the cbl2/3rf mutant were smaller in size and exhibited reduced weight and fatty acid content compared to wild‐type, but accumulation of sucrose was not altered. Moreover, accumulation of inositol hexakisphosphate (InsP6), the major storage form of phosphorus in seeds, was significantly reduced in mutant seeds. In addition, complete loss of CBL2 and CBL3 function in cbl2/3lf resulted in a high frequency of severe defects in embryonic development. Together, our findings reveal a crucial function of Ca2+‐controlled processes at the vacuolar membrane as determinants of seed yield and size, and demonstrate the importance of vacuolar CBL calcium sensors for plant embryogenesis.
Cine EPID evaluation of two non‐commercial techniques for DIBH
Authors: Jensen Christopher , Urribarri Jaime , Cail Daniel , Rottmann Joerg , Mishra Pankaj , Lingos Tatiana , Niedermayr Thomas , Berbeco Ross 
Published: January 2014

Purpose:To evaluate the efficacy of two noncommercial techniques for deep inspiration breathhold (DIBH) treatment of left‐sided breast cancer (LSBC) usingcine electronic portal imaging device (EPID) images.Methods:23 875 EPID images of 65 patients treated for LSBC at two different cancer treatment centers were retrieved. At the Milford Regional Cancer Center, DIBH stability was maintained by visual alignment of inroom lasers and patient skin tattoos (TAT). At the South Shore Hospital, a distance‐measuring laser device (RTSSD) was implemented. For both centers,cine EPID images were acquired at least once per week during beam‐on. Chest wall position relative to image boundary was measured and tracked over the course of treatment for every patient and treatment fraction for which data were acquired.Results:Median intrabeam chest motion was 0.31 mm for the TAT method and 0.37 mm for the RTSSD method. The maximum excursions exceeded our treatment protocol threshold of 3 mm in 0.3% of cases (TAT) and 1.2% of cases (RTSSD). The authors did not observe a clinically significant difference between the two datasets.Conclusions:Both noncommercial techniques for monitoring the DIBH location provided DIBH stability within the predetermined treatment protocol parameters (<3 mm). The intreatment imaging offered by the EPID operating incine mode facilitates retrospective analysis and validation of both techniques.
Draft Genome Sequence of Pseudomonas chlororaphis YL-1, a Biocontrol Strain Suppressing Plant Microbial Pathogens
Authors: Liu Youzhou , Lu Shi-En , Baird Sonya M. , Qiao Junqing , Du Yan 
Published: January 2014

ABSTRACT

Pseudomonas chlororaphis
YL-1 was isolated from soybean root tips and showed a broad range of antagonistic activities to microbial plant pathogens. Here, we report the high-quality draft genome sequence of YL-1, which consists of a chromosome with an estimated size of 6.8 Mb with a G+C value of 63.09%.
Genome Sequence of the Emerging Plant Pathogen Dickeya solani Strain RNS 08.23.3.1A
Authors: Khayi Slimane , Mondy Samuel , Beury-Cirou Amélie , Moumni Mohieddine , Hélias Valérie , Faure Denis 
Published: January 2014

ABSTRACT

Here we present the genome sequence of
Dickeya solani
strain RNS 08.23.3.1A (PRI3337), isolated from
Solanum tuberosum
.
Dickeya solani
, recently described on potato cultures in Europe, is a proposed new taxon closely related to the
Dickeya dianthicola
and
Dickeya dadantii
species.
Timing and presence of an attachment person affect sensitivity of aggression tests in shelter dogs
Authors: Kis A. , Klausz B. , Persa E. , Miklósi Á. , Gácsi M. 
Published: January 2014

Different test series have been developed and used to measure behaviour in shelter dogs in order to reveal individuals not suitable for re‐homing due to their aggressive tendencies. However, behavioural tests previously validated on pet dogs seem to have relatively low predictability in the case of shelter dogs. Here, we investigate the potential effects of (1) timing of the behaviour testing and (2) presence of a human companion on dogs' aggressive behaviour. In Study I, shelter dogs (n=25) showed more aggression when tested in a short test series two weeks after they had been placed in the shelter compared to their responses in the same test performed 1–2 days after arrival. In Study II, the occurrence of aggressive behaviour was more probable in pet dogs (n=50) in the presence than in the absence of their passive owner. We conclude that the sensitivity of aggression tests for shelter dogs can be increased by running the test in the presence of a caretaker, and after some period of acclimatisation to the new environment. This methodology could also provide better chances for successful adoption.
The NADPH Oxidase Inhibitor Imipramine-Blue in the Treatment of Burkitt Lymphoma
Authors: Klingenberg Marcel , Becker Jürgen , Eberth Sonja , Kube Dieter , Wilting Jörg 
Published: January 2014

Abstract
Burkitt lymphoma is a rare malignancy arising from B cells. Current chemotherapeutic regimens achieve excellent overall survival rates in children, but less impressive rates in adults. There are cases with poor outcome caused by toxic effects of the therapy, tumor lysis syndrome, or metastatic spread of lymphomas to the central nervous system. Modulators of reactive oxygen species are currently discussed as potential drugs for the treatment of cancer. The NADPH oxidase 4 inhibitor imipramine-blue might satisfy the aforementioned requirements, and was studied here. We used MTT assay, crystal violet assay, and thymidine 3H-incorporation assay to analyze the effects of imipramine-blue on Burkitt lymphoma (BL2, BL2B95, BL30B95, BL41B95), neuroblastoma (KELLY, SH-SY5Y, SMS-KAN), cervix carcinoma (HeLa), breast cancer (MDA-MB231), angiosarcoma (AS-M), human embryonic kidney (HEK293WT), and nonmalignant (FLP1) cell lines. The effects of imipramine-blue on BL2B95 cells in vivo were investigated in xenografts on the chick chorioallantoic membrane (CAM). We report that imipramine-blue is a potent growth inhibitor for several cancer cell lines in vitro with IC50 values comparable to those of doxorubicin (0.16–7.7 μmol/L). Tumor size of BL2B95 cells inoculated in the CAM was reduced significantly (P &lt; 0.05) after treatment with 10 μmol/L imipramine-blue. Lymphogenic dissemination of BL2B95 and the formation of blood and lymphatic vessels in experimental tumors were not affected. We show that imipramine-blue can be used to decrease the viability of cancer cell lines in vitro and in vivo. Imipramine-blue reduces the size of experimental Burkitt lymphoma significantly but does not affect the dissemination of BL2B95 cells, angiogenesis, and lymphangiogenesis. Mol Cancer Ther; 13(4); 833–41. ©2014 AACR.
HIV-1 Matrix Protein p17 Promotes Lymphangiogenesis and Activates the Endothelin-1/Endothelin B Receptor Axis
Authors: Caccuri Francesca , Rueckert Christine , Giagulli Cinzia , Schulze Kai , Basta Daniele , Zicari Sonia , Marsico Stefania , Cervi Edoardo , Fiorentini Simona , Slevin Mark , Guzman Carlos A. , Caruso Arnaldo 
Published: January 2014

Objective—
AIDS-related lymphomas are high grade and aggressively metastatic with poor prognosis. Lymphangiogenesis is essential in supporting proliferation and survival of lymphoma, as well as tumor dissemination. Data suggest that aberrant lymphangiogenesis relies on action of HIV-1 proteins rather than on a direct effect of the virus itself. HIV-1 matrix protein p17 was found to accumulate and persist in lymph nodes of patients even under highly active antiretroviral therapy. Because p17 was recently found to exert a potent proangiogenic activity by interacting with chemokine (C-X-C motif) receptors 1 and 2, we tested the prolymphangiogenic activity of the viral protein.

Approach and Results—
Human primary lymph node–derived lymphatic endothelial cells were used to perform capillary-like structure formation, wound healing, spheroids, and Western blot assays after stimulation with or without p17. Here, we show that p17 promotes lymphangiogenesis by binding to chemokine (C-X-C motif) receptor-1 and chemokine (C-X-C motif) receptor-2 expressed on lymph node–derived lymphatic endothelial cells and activating the Akt/extracellular signal–regulated kinase signaling pathway. In particular, it was found to induce capillary-like structure formation, sprout formation from spheroids, and increase lymph node–derived lymphatic endothelial cells motility. The p17 lymphangiogenic activity was, in part, sustained by activation of the endothelin-1/endothelin receptor B axis. A Matrigel plug assay showed that p17 was able to promote the outgrowth of lymphatic vessels in vivo, demonstrating that p17 directly regulates lymphatic vessel formation.

Conclusions—
Our results suggest that p17 may generate a prolymphangiogenic microenvironment and plays a role in predisposing the lymph node to lymphoma growth and metastasis. This finding offers new opportunities to identify treatment strategies in combating AIDS-related lymphomas.
Venous Phase of Computed Tomography Angiography Increases Spot Sign Detection, but Intracerebral Hemorrhage Expansion Is Greater in Spot Signs Detected in Arterial Phase
Authors: Rodriguez-Luna David , Dowlatshahi Dar , Aviv Richard I. , Molina Carlos A. , Silva Yolanda , Dzialowski Imanuel , Lum Cheemun , Czlonkowska Anna , Boulanger Jean-Martin , Kase Carlos S. , Gubitz Gord , Bhatia Rohit , Padma Vasantha , Roy Jayanta , Stewart Teri , Huynh Thien J. , Hill Michael D. , Demchuk Andrew M. 
Published: January 2014

Background and Purpose—
Variability in computed tomography angiography (CTA) acquisitions may be one explanation for the modest accuracy of the spot sign for predicting intracerebral hemorrhage expansion detected in the multicenter Predicting Hematoma Growth and Outcome in Intracerebral Hemorrhage Using Contrast Bolus CT (PREDICT) study. This study aimed to determine the frequency of the spot sign in intracerebral hemorrhage and its relationship with hematoma expansion depending on the phase of image acquisition.

Methods—
PREDICT study was a prospective observational cohort study of patients with intracerebral hemorrhage presenting within 6 hours from onset. A post hoc analysis of the Hounsfield units of an artery and venous structure were measured on CTA source images of the entire PREDICT cohort in a core laboratory. Each CTA study was classified into arterial or venous phase and into 1 of 5 specific image acquisition phases. Significant hematoma expansion and total hematoma enlargement were recorded at 24 hours.

Results—

Overall (n=371), 77.9% of CTA were acquired in arterial phase. The spot sign, present in 29.9% of patients, was more frequently seen in venous phase as compared with arterial phase (39% versus 27.3%;
P
=0.041) and the later the phase of image acquisition (
P
=0.095). Significant hematoma expansion (
P
=0.253) and higher total hematoma enlargement (
P
=0.019) were observed more frequently among spot sign–positive patients with earlier phases of image acquisition.

Conclusions—
Later image acquisition of CTA improves the frequency of spot sign detection. However, spot signs identified in earlier phases may be associated with greater absolute enlargement. A multiphase CTA including arterial and venous acquisitions could be optimal in patients with intracerebral hemorrhage.
The Atmospheric Response to Surface Heating under Maximum Entropy Production
Authors: Gjermundsen A. , LaCasce J. H. , Graff L. S. 
Published: January 2014

Abstract
In numerous studies, midlatitude storm tracks have been shown to shift poleward under global warming scenarios. Among the possible causes, changes in sea surface temperature (SST) have been shown to affect both the intensity and the position of the tracks. Increased SSTs can increase both the lateral heating occurring in the tropics and the midlatitude temperature gradients, both of which increase tropospheric baroclinicity.
To better understand the response to altered SST, a simplified energy balance model (EBM) is used. This employs the principal of maximum entropy production (MEP) to determine the meridional heat fluxes in the atmosphere. The model is similar to one proposed by Paltridge (1975) but represents only the atmospheric response (the surface temperatures are fixed). The model is then compared with a full atmospheric general circulation model [Community Atmosphere Model, version 3 (CAM3)].
In response to perturbed surface temperatures, EBM exhibits similar changes in (vertically integrated) air temperature, convective heat fluxes, and meridional heat transport. However, the changes in CAM3 are often more localized, particularly at low latitudes. This, in turn, results in a shift of the storm tracks in CAM3, which is largely absent in EBM. EBM is more successful, however, at representing the response to changes in high-latitude heating or cooling. Therefore, MEP is evidently a plausible representation for heat transport in the midlatitudes, but not necessarily at low latitudes.
Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease
Authors: Muthukumaran Krithika , Leahy Samantha , Harrison Kate , Sikorska Marianna , Sandhu Jagdeep K , Cohen Jerome , Keshan Corrine , Lopatin Daniel , Miller Harvey , Borowy-Borowski Henryk , Lanthier Patricia , Weinstock Shelly , Pandey Siyaram 
Published: January 2014

Abstract
Background
Paraquat, still used as an herbicide in some parts of the world, is now regarded as a dangerous environmental neurotoxin and is linked to the development Parkinson’s disease (PD). Paraquat interacts with cellular redox systems and causes mitochondrial dysfunction and the formation of reactive oxygen species, which in turn, plays a crucial role in the pathophysiology of PD. Various antioxidant therapies have been explored with the expectations that they deliver health benefits to the PD patients, however, no such therapies were effective. Here we have tested the neuroprotective efficacy of a novel water-soluble CoQ10 (Ubisol-Q10), in a rat model of paraquat-induced neurodegeneration in order to evaluate its potential application in the management of PD.

Results
We have developed a rat model of progressive nigrostriatal degeneration by giving rats five intraperitoneal injections of paraquat (10 mg/kg/injection), once every five days. Neuronal death occurred over a period of 8 weeks with close to 50% reduction in the number of tyrosine hydroxylase-positive cells. Ubisol-Q10, at 6 mg CoQ10/kg body weight/day, was delivered as a supplement in drinking water. The intervention begun after the completion of paraquat injections when the neurodegenerative process had already began and about 20% of TH-positive neurons were lost. Ubisol-Q10 treatment halted the progression of neurodegeneration and remaining neurons were protected. The outcomes were evaluated based on the number of surviving tyrosine hydroxylase-positive neurons in the substantia nigra region and improved motor skills in response to the Ubisol-Q10 intervention. To maintain this neuroprotection, however, continuous Ubisol- Q10 supplementation was required, if withdrawn, the neuronal death pathway resumed, suggesting that the presence of CoQ10 was essential for blocking the pathway.

Conclusion
The CoQ10, given orally as Ubisol-Q10 in drinking solution, was effective in blocking the progression of neurodegeneration when administered therapeutically (post-toxin injection), at a much lower concentration than other previously tested oil soluble formulations and well within the acceptable daily intake of 12 mg/kg/day. Such unprecedented neuroprotection has never been reported before. These results are very encouraging and suggest that Ubisol-Q10 should be further tested and developed as a therapy for halting the progression of PD.
Data model, dictionaries, and desiderata for biomolecular simulation data indexing and sharing
Authors: Thibault Julien C , Roe Daniel R , Facelli Julio C , Cheatham Thomas E 
Published: January 2014

Abstract

Background
Few environments have been developed or deployed to widely share biomolecular simulation data or to enable collaborative networks to facilitate data exploration and reuse. As the amount and complexity of data generated by these simulations is dramatically increasing and the methods are being more widely applied, the need for new tools to manage and share this data has become obvious. In this paper we present the results of a process aimed at assessing the needs of the community for data representation standards to guide the implementation of future repositories for biomolecular simulations.

Results
We introduce a list of common data elements, inspired by previous work, and updated according to feedback from the community collected through a survey and personal interviews. These data elements integrate the concepts for multiple types of computational methods, including quantum chemistry and molecular dynamics. The identified core data elements were organized into a logical model to guide the design of new databases and application programming interfaces. Finally a set of dictionaries was implemented to be used via SQL queries or locally via a Java API built upon the Apache Lucene text-search engine.

Conclusions
The model and its associated dictionaries provide a simple yet rich representation of the concepts related to biomolecular simulations, which should guide future developments of repositories and more complex terminologies and ontologies. The model still remains extensible through the decomposition of virtual experiments into tasks and parameter sets, and via the use of extended attributes. The benefits of a common logical model for biomolecular simulations was illustrated through various use cases, including data storage, indexing, and presentation. All the models and dictionaries introduced in this paper are available for download at http://ibiomes.chpc.utah.edu/mediawiki/index.php/Downloads.
Changes in endotracheal tube cuff pressure in mechanically ventilated adult patients
Authors: Motoyama Asuka , Asai Shota , Konami Hiroyuki , Matsumoto Yuri , Misumi Takuyo , Imanaka Hideaki , Nishimura Masaji 
Published: January 2014

Abstract
During mechanical ventilation, endotracheal tube cuff pressure should be maintained within proper range. We investigated the effect of frequent adjustment on cuff pressure in 27 mechanically ventilated patients. Cuff pressure was recorded every 2 h and was adjusted to 24 cmH2O each time. We found that cuff pressure was decreased by 4.9 ± 2.9 cmH2O from the target value. Cuff pressure decreased to less than 20 cmH2O in 45% of measurement occasions 2 h after adjusting it to 24 cmH2O.