bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of features and classification techniques in breast cancer detection for Biglycan biomarker images
Authors: Ma’touq Jumana , Alnuman Nasim 
Published: August 2024

BACKGROUND: Breast cancer (BC) is considered the world’s most prevalent cancer. Early diagnosis of BC enables patients to receive better care and treatment, hence lowering patient mortality rates. Breast lesion identification and classification are challenging even for experienced radiologists due to the complexity of breast tissue and variations in lesion presentations. OBJECTIVE: This work aims to investigate appropriate features and classification techniques for accurate breast cancer detection in 336 Biglycan biomarker images. METHODS: The Biglycan biomarker images were retrieved from the Mendeley Data website (Repository name: Biglycan breast cancer dataset). Five features were extracted and compared based on shape characteristics (i.e., Harris Points and Minimum Eigenvalue (MinEigen) Points), frequency domain characteristics (i.e., The Two-dimensional Fourier Transform and the Wavelet Transform), and statistical characteristics (i.e., histogram). Six different commonly used classification algorithms were used; i.e., K-nearest neighbours (k-NN), Naïve Bayes (NB), Pseudo-Linear Discriminate Analysis (pl-DA), Support Vector Machine (SVM), Decision Tree (DT), and Random Forest (RF). RESULTS: The histogram of greyscale images showed the best performance for the k-NN (97.6%), SVM (95.8%), and RF (95.3%) classifiers. Additionally, among the five features, the greyscale histogram feature achieved the best accuracy in all classifiers with a maximum accuracy of 97.6%, while the wavelet feature provided a promising accuracy in most classifiers (up to 94.6%). CONCLUSION: Machine learning demonstrates high accuracy in estimating cancer and such technology can assist doctors in the analysis of routine medical images and biopsy samples to improve early diagnosis and risk stratification.
Long-Term Safety of Gantenerumab in Participants with Alzheimer’s Disease: A Phase III, Double-Blind, and Open-Label Extension Study (Marguerite RoAD)
Authors: Neve Anuja , Das Bibha , Wojtowicz Jakub , Huang Zhiyue , Bullain Szofia , Watkin Michelle , Lott Dominik , Bittner Tobias , Delmar Paul , Klein Gregory , Hofmann Carsten , Kerchner Geoffrey A. , Smith Janice , Baudler Monika , Fontoura Paulo , Doody Rachelle S. 
Published: August 2024

Background: Gantenerumab is an anti-amyloid-β immunoglobulin G1 monoclonal antibody for subcutaneous (SC) administration. The efficacy and safety of low-dose (105 mg or 225 mg) gantenerumab were investigated in Marguerite RoAD (MR; NCT02051608), a Phase III, double-blind (DB), placebo-controlled study in participants with mild Alzheimer’s disease (AD) dementia. Following a preplanned futility analysis of the SCarlet RoAD study (NCT01224106), MR was converted into an open-label extension (OLE). Objective: The DB study aimed to assess the efficacy of gantenerumab compared with placebo from baseline to Week 104 in participants with mild AD dementia. Following conversion to an OLE, this objective became exploratory, as the OLE assessed the long-term safety and tolerability of SC gantenerumab at doses of up to 1,200 mg every 4 weeks (Q4W) in OLE participants. Methods: Eligible DB study participants were offered the opportunity to receive gantenerumab up-titrated to 1,200 mg Q4W. Safety and tolerability were assessed using magnetic resonance imaging (MRI), physical and neurologic examinations, and adverse event monitoring. Results: Overall, 225 participants were rolled over from the DB part of MR and received ≥1 gantenerumab dose in the OLE. The median treatment duration was 123 weeks. Fifty-nine (26.2%) and 41 (18.2%) participants had amyloid-related imaging abnormality (ARIA)-edema and ARIA-hemorrhage MRI findings, respectively. ARIA findings were manageable with MRI monitoring and dose intervention; most were asymptomatic. There were no unexpected safety findings. Conclusions: SC gantenerumab at doses of up to 1,200 mg Q4W were well tolerated in participants with mild AD dementia.
Cardiac Involvement in LAMA2-Related Muscular Dystrophy and SELENON-Related Congenital Myopathy: A Case Series
Authors: Bouman Karlijn , van den Heuvel Frederik M.A. , Evertz Reinder , Boesaard Ewout , Groothuis Jan T. , van Engelen Baziel G.M. , Nijveldt Robin , Erasmus Corrie E. , Udink ten Cate Floris E.A. , Voermans Nicol C. 
Published: August 2024

Background: LAMA2-related muscular dystrophy (LAMA2-MD) and SELENON-related myopathy (SELENON-RM) are two rare neuromuscular diseases characterized by proximal and axial muscle weakness, scoliosis, spinal rigidity, low bone quality and respiratory impairment. Cardiac involvement has previously been described in retrospective studies and case reports, but large case series and prospective studies in unselected cohorts are lacking. Objective: The objective of this study is to conduct prevalence estimations, perform cardiac phenotyping, and provide recommendations for clinical care. Methods: In this case series including two time points, we conducted comprehensive assessments with electrocardiography (ECG) and transthoracic echocardiography (TTE). ECGs were systematically assessed for a large subset of variables. TTE included left and right ventricular ejection fraction (LVEF/RVEF) and left ventricular global longitudinal strain (GLS), the latter being a more early and sensitive marker of left ventricular dysfunction. Results: 21 LAMA2-MD (M = 5; 20±14 years) and 10 SELENON-RM patients (M = 7; 18±12 years) were included. In most patients, QRS fragmentation and Q waves, markers of heterogeneous ventricular activation, were present both at baseline and at follow-up. GLS was abnormal (age specific in children, > –18% in adults) in 33% of LAMA2-MD and 43% of SELENON-RM patients at baseline. Reduced LVEF (<52% in males, <54% in females and <55% in pediatric population) was observed in three LAMA2-MD patients at baseline and in none of the SELENON-RM patients. GLS and LVEF did not change between baseline and follow-up. RVEF was normal in all patients. Conclusion: ECG abnormalities and abnormal GLS are prevalent in LAMA2-MD and SELENON-RM, yet abnormal LVEF was only seen in LAMA2-MD patients. One LAMA2-MD patient had a clinically relevant deterioration in LVEF during 1.5-year follow-up. We advise routine screening of all patients with LAMA2-MD or SELENON-RM with ECG and echocardiography at diagnosis, minimally every two years from second decade of life and if new cardiac signs arise.
New skills in symbolic data analysis for official statistics
Authors: Verde Rosanna , Batagelj Vladimir , Brito Paula , Silva A. Pedro Duarte , Korenjak-Černe Simona , Dobša Jasminka , Diday Edwin 
Published: August 2024

The paper draws attention to the use of Symbolic Data Analysis (SDA) in the field of Official Statistics. It is composed of three sections presenting three pilot techniques in the field of SDA. The three contributions range from a technique based on the notion of exactly unified summaries for the creation of symbolic objects, a model-based approach for interval data as an innovative parametric strategy in this context, and measures of similarity defined between a class and a collection of classes based on the frequency of the categories which characterize them. The paper shows the effectiveness of the proposed approaches as prototypes of numerous techniques developed within the SDA framework and opens to possible further developments.
Evaluating the therapeutic effects of NiaoDuQing particles on chronic kidney disease based on real world study
Authors: Sun Rui , Hao Jianfeng , Li Qian , Xie Weinan , Hu Xiaoyan , Chen Zhenzhen , Liu Zhi , Yuan Ling 
Published: August 2024

BACKGROUND: NiaoDuQing Particle is the first Chinese herbal medicine approved by the China Food and Drug Administration for the treatment of chronic kidney disease. It has been used in clinical practice in China for over twenty years. However, there is limited literature reporting on the long-term therapeutic effects of NiaoDuQing Particles on chronic kidney disease patients. OBJECTIVE: This research aimed to comprehensively assess the therapeutic effect of NiaoDuQing Particles (NDQP) on chronic kidney disease patients based on clinical data analysis. METHODS: This study was carried out on a total of 148 participants diagnosed with different types of chronic kidney disease. Demographics information, chronic kidney disease classification and chronic kidney disease diganostic indicators were collected and analyzed before and after NiaoDuQing Particles treatment for 3, 6, 9, 12 and 18 months respectively. RESULTS: In all 148 patients, mean eGFR value was increased after NiaoDuQing Particles treatment for up to 18 months, and was statistically significant at month 3, 6, 9, 12 and 18 ([Formula: see text] 0.05). Mean uric acid value was decreased after NiaoDuQing Particles treatment for up to 18 months, and was statistically significant at month 3, 6, 9, 12 and 18 ([Formula: see text] 0.05). Mean urea nitrogen value was decreased after NiaoDuQing Particles treatment for up to 18 months and was statistically significant at month 3, 6, 9, 12 and 18 ([Formula: see text] 0.05). While mean creatinine value was decreased after NiaoDuQing Particles treatment for up to 18 months and was statistically significant at month 6 ([Formula: see text] 0.05). CONCLUSIONS: NiaoDuQing Particles could maintain the stable state of chronic kidney disease patients for up to 18 months especially in improving diagnostic indicators like eGFR, uric acid and urea nitrogen.
Comparison between laparoscopic complete mesocolic excision and D2 radical operation in colon carcinoma resection: A propensity score matching analysis
Authors: Han Zhen , Liu Yangan , Tan Ming , Hua Zhaolai , Dai Chun 
Published: August 2024

BACKGROUND: Surgery remains the most effective treatment for colon cancer. However, there are still controversies regarding the tumor treatment effect, prognosis, and perioperative impact of complete mesocolic excision (CME) surgery in colon carcinoma resection. OBJECTIVE: This study aims to compare laparoscopic complete mesocolic excision (LCME) and traditional open D2 radical surgery in colon carcinoma resection through a retrospective analysis using 1:1 propensity score matching (PSM). METHODS: 98 cases undergoing LCME or open D2 colon carcinoma resection at our hospital from January 2014 to November 2021 were retrospectively collected. After excluding cases and 1:1 matching using PSM based on baseline clinical data, 86 patients were assigned in research queue. 43 patients were in each group. Two groups were compared for general clinical baseline indicators. Surgical results and postoperative adverse events of patients were also compared. Disease-free survival (DFS) rate and overall survival (OS) rate was analyzed. RESULTS: After 1:1 PSM matching, there was no statistically significant differences in baseline data between the LCME group and D2 group ([Formula: see text] 0.05). LCME was characterized by longer total duration of surgery ([Formula: see text] 0.001), less intraoperative bleeding volume ([Formula: see text] 0.001), more postoperative drainage fluid volume ([Formula: see text] 0.001), greater number of lymph nodes retrieved ([Formula: see text] 0.014). No statistically differences was observed regarding intraoperative blood transfusion, hospital stay, Clavien-Dindo complicating disease classification (all [Formula: see text] 0.05), 1 and 3-year DFS rate ([Formula: see text] 0.84) and OS rate ([Formula: see text] 0.1). CONCLUSION: LCME had a longer duration of surgery but less intraoperative bleeding volume and more postoperative drainage fluid volume and retrieved lymph nodes compared to D2 radical surgery. LCME surgery is comparable to D2 surgery in terms of postoperative prognosis, but LCME surgery shows a positive trend in the overall survival curve.
Effect of SBRT plus immunotherapy on immune status and survival quality of NSCLC patients: A study of combined radiotherapy and immunotherapy
Authors: Shao Liang , Gao Ying , Zhang Dan , Yang Mengdan , Jiang Mimi , Li Hongfeng , Yan Yanting 
Published: August 2024

BACKGROUND: non-small cell lung cancer (NSCLC) accounts for more than 80% of all lung cancer populations. Stereotactic radiotherapy (SBRT) is mainly suitable for early NSCLC patients who are not suitable for surgery or refuse surgery. OBJECTIVE: To analyze the effects of stereotactic radiotherapy (SBRT) plus immunotherapy for non-small cell lung cancer (NSCLC) patients on their immune status and survival quality. METHODS: NSCLC patients admitted to our hospital from 2019–2022 were divided into 61 cases in control group (SBRT) and 60 cases in observation group (SBRT plus immunotherapy) by the randomized numerical table method to compare the efficacy, the level of tumor markers in the serum, the level and activity of the immune cells in the peripheral blood and the Kahlil’s functional status (KPS) scores. RESULTS: The observation group had a higher efficacy rate than that of the control group ([Formula: see text] 0.05). There was no statistical difference between the two groups in serum tumor marker content, immune cell level and activity in peripheral blood and KPS score before treatment ([Formula: see text] 0.05). After treatment, serum tumor markers were lower than those in control group, and immune cell level, NK cell-related activity and KPS score were higher than those in control group ([Formula: see text] 0.05). CONCLUSION: SBRT plus immunotherapy can reduce the level of various tumor markers, improve the immune status and quality of survival for NSCLC patients.
The Role of Human Dignity in Addressing LGBT: Perspectives on Islam, Human Rights, and Maqosidh Sharia
Authors: Habibah Nurul Fitri 
Published: August 2024

This study aims to find out how the role of human dignity in responding to LGBT perspectives of Islam, human rights and Maqasidh Sharia. This study used qualitative research. The method of data collection is by using literature studies or literature that uses books and journals. The data analysis technique is sourced from literature studies. The author emphasizes on which references or libraries are related to the author's title to conduct research. lgbt acts are not permissible according to Islam, human rights and Maqasidh Sharia. But we must not judge people who commit deviant acts like lgbt. The need to set aside religious rules first does not mean to justify lgbt actions but it is related to human values or what we can call human dignity. It would be better if we could embrace people who commit these lgbt acts in the hope that they can return to being normal human beings and carry out their sexual orientation accordingly by and large.
Keywords: Human Dignity, LGBT, Islam, Human Rights and Maqasidh Sharia

Abstrak
Penelitian ini berorientasi supaya mengetahui bagaimana peran martabat manusia dalam menyikapi lgbt perspektif islam, ham dan maqosidh Syariah. Adapun penelitian ini menggunakan penelitian kualitatif. Adapun cara pengumpulan datanya dengan menggunakan studi literatur atau kepustakaan yang menggunakan buku dan jurnal. Adapun teknik analisis datanya bersumber dari studi literatur. penulis menekankan pada referensi atau pustaka mana yang terkait dengan judul penulis untuk melakukan penelitian. Tindakan lgbt tidak dibenarkan menurut islam, ham dan maqosidh Syariah. Namun kita tidak boleh menghakimi manusia yang melakukan tindakan menyimpang seperti lgbt ini. perlunya untuk menyampingkan aturan agama terlebih dahulu bukan berarti untuk membenarkan tindakan lgbt tetapi ini berkaitan dengan nilai-nilai kemanusian atau yang bisa kita sebut dengan martabat manusia. Alangkah lebih baiknya jika kita bisa merangkul manusia yang melakukan tindakan lgbt ini dengan harapan supaya bisa kembali menjadi manusia yang normal dan melakukan orientasi seksualnya sesuai pada umumnya.
Kata kunci: Martabat Manusia, LGBT, Islam, HAM dan Maqasidh Syariah
Pelaksanaan Pendidikan Kesehatan terhadap Perilaku Hidup Bersih dan Sehat (PHBS)
Authors: Trisasri Ruri , Putri Isriyatil Jannah  , Nabela Putri Yanuari  
Published: August 2024

Background of Study: Boarding School are Islamic education dormitories that need attention about health because many students live in them. Boarding schools are strategic place to increase students’ knowledge about health to change attitudes and behavior of individual hygiene. This can be implemented by providing health education for students by instilling clean and healthy living behavior to improve healthy living skills from an early age. The aim of this study was to correlate clean and healthy living behavior of high school students in Ibnul Qoyyim Boarding School for Boys.
Methods: Research design used in this study was cross sectional. Population in this research was all high school students in Ibnul Qoyyim Boarding School for boys. The sampling technique used was purposive sampling technique, so the samples taken were 86 students with inclusion criteria. Data analysis used SPSS application with Chi-square test (p < 0,05) to correlate health education with clean and healthy living behavior by 8 indicators from Ministry of Health Indonesia.
Results: The most respondent were 16 years old (30.2%). And 72% have received Health Education but only 12,8% have applied clean and healthy living behavior. The result of statistical test showed that there was no correlation in correlation between health education with clean and healthy living behavior (p value = 0.681; PR = 1.180). But, from Prevalence Ratio value, the implementation of health education is a factor that can affect PHBS in students by 1,180 times compared to students who have not received health education for the last 6 months.
Conclusion: There was no correlation between health education with clean and healthy living behavior of high school students in Ibnul Qoyyim Boarding School for Boys.
Keywords: Health Education, Health Behavior, Boarding School
Superradiance: the principles of generation and implementation in lasers*
Authors: Kocharovsky VI V , Zheleznyakov V V , Kocharovskaya E R , Kocharovsky V V 
Published: August 2024

Abstract
The electrodynamics of active continuous media is applied to theoretically examine collective spontaneous emission regimes of dipole oscillator ensembles. Recent experiments in which the superfluorescence phenomenon has been observed are reviewed. The focus is on propagation and interaction effects experienced by the inhomogeneous waves of active center polarization and electromagnetic fields. The superradiant laser dynamics is examined and prospects for the realization of superradiant lasers using low-Q cavities are discussed.
PENGARUH METODE TALKING STICK TERHADAP HASIL BELAJAR SISWA KELAS X MATA PELAJARAN PENDIDIKAN AGAMA ISLAM DI SMK NU 01 JOGOROTO JOMBANG
Authors: Hana Al Fazila  , Hasan Zaenal Arifin 
Published: August 2024

Pada umumnya pusat saat proses pembelajaran adalah berfokus pada pengajar. Dalam proses meningkatkan keberhasilan belajar siswa, yang memiliki peran penting adalah guru. Biasanya pembelajaran yang terjadi adalah siswa duduk dan menyimak apa yang disampaikan oleh gurunya yang menjadikan keefektifan belajar menjadi kurang. Dengan ini, maka diperlukan sebuah metode belajar agar keaktifan kembali hidup. Artikel ini bertujuan untuk mengetahui megetahui pelaksanaan, hasil belajar dan pengaruh metode Talking Stick terhadap hasil belajar siswa kelas X Mata Pelajaran Pendidikan Agama Islam. Penelitian ini mengguanakan metode kuantitatif dengan quasi-experimental one-group pretest-posttest design. Dalam pengumpulan data menggunakan pengamatan, test, dan foto-foto. Hasil penelitian ini yaitu 1). Pelaksanaan metode ini berjalan dengan baik. Dibuktikan dengan tabel distribusi frekuensi yaitu frekuensi sebanyak 12 dengan interval 85-95 dan presentase sebesar 46.15% termasuk dalam kategori baik. 2). Pada kelas percobaan diketahui nilai mean pretest 55,00 dan posttest 87,88. Sedangkan kelas kontrol, mean nilai pretest nya 42,69 dan posttest 63,27. Keluaran belajar siswa kelas X mapel PAI di SMK NU 01 Jogoroto Jombang meningkat sebagai bentuk Indikator dari nilai mean. 3). Hasil perhitungan paired sample t test menggunakan dengan tingkat kepercayaan 95% nilai Sig. (2tailed) adalah sebesar 0,000 (0,000 < 0,05) yang artinya H0 ditolak dan Ha diterima.
IMPLEMENTASI PEMBELAJARAN INTERAKTIF UNTUK MENINGKATKAN MINAT BELAJAR PAI DI SMPN 2 NGORO JOMBANG
Authors: Chafid Charis Mochammad , Anshori Sholihul 
Published: August 2024

Abstrak: Suatu keadaan yang berusaha menciptakan keadaan belajar antar siswa bisa saling aktif untuk menunjukkan mereka mampu melalui proses belajar bersama guru dengan saling menyampaikan pendapat itulah yang disebut implementasi pada sebuah model belajar yang interaktif. Berdasarkan masalah diatas, penelitian ini mempunyai 3 tujuan yang berkaitan yaitu cara implementasi pembelajaran interaktif, minat belajar serta faktor pendukung juga penghambat untuk melaksanakan pembelajaran Interaktif di SMPN 2 Ngoro Jombang. Jenis penelitiannya adalah penelitian studi kasus. Model yang diambil sebagai metode adalah kualitatif. Berdasarkan hasil penelitian ditemukan bahwa: pembelajaran interaktif ini bisa membuat siswa semakin mudah dikondisikan karena perhatian penuk yang dilakukan oleh guru kaena ada komunikasi secara dua arah, dan minat belajar siswa ini bisa terjadi karena adanya metode yang menyenangkan peserta didik dan adanya fasilitas yang memadai untuk melakukan kegiatan yang mengarah pada peserta didik yang mampu belajar dengan aktif dan merasa senang dalam mengikutinya.
Kata kunci: Pembelajaran Interaktif, Minat Belajar PAI