bluuebunny/crossref_metadata_2025_split huggingface dataset:
Athletes with higher VO2max present reduced oxLDL after a marathon race
Authors: Bachi André L L , Sierra Ana Paula R , Rios Francisco J O , Gonçalves Danieli A , Ghorayeb Nabil , Abud Ronaldo L , Victorino Angélica B , dos Santos Juliana M B , Kiss Maria Augusta D P , Pithon-Curi Tania C , Vaisberg Mauro 
Published: November 2015

BackgroundDuring a session of prolonged and exhaustive exercise, such as a marathon race, large quantities of free radicals are produced and can oxidise (ox) several molecules, such as low-density lipoprotein (LDL). To prevent oxidative damage, athletes present higher antioxidant levels. However, the effect of marathon running on the natural IgM or IgG anti-oxLDL autoantibodies is not understood. Thus, we investigated the effect of a marathon race on oxidative stress and the mechanisms of control of this stress.MethodsBlood samples of 20 marathon runners were collected 24 hours before, immediately and 72 hours after a marathon race to evaluate: plasma lipid profile; serum levels of oxLDL and anti-oxLDL autoantibodies (IgM and IgG isotype) and total antioxidant capacity (TAC). Maximum oxygen uptake (VO2max) was also determined.ResultsImmediately after the race, oxLDL and TAC levels decreased in comparison to the basal levels; however, the IgM or IgG anti-oxLDL levels remain unchanged. Whereas no differences were observed in the IgM or IgG anti-oxLDL levels 72h after the marathon, the oxLDL and TAC levels returned to the basal values. Significant positive correlations were observed between oxLDL and LDL-cholesterol before, and 72h after the marathon. Significant negative correlations were observed between oxLDL and VO2max immediately after the marathon and 72 h later, as well as between oxLDL and TAC 72 h after the race.ConclusionsAthletes with a higher VO2max and total antioxidant activity presented reduced LDL oxidation. The levels of IgM or IgG anti-oxLDL autoantibodies were not affected by running the marathon.
Motocross biking for competition and for recreation: a prospective analysis of 423 injured riders
Authors: Singh Rohit , Theobald Peter , Hamad AK , Hay Stuart 
Published: November 2015

BackgroundMotocross is a form of motorcycle racing held on established off-road circuits and has been a recreational and competitive sport across the world for over 100 years. In the UK alone, motocross has grown into a phenomenally ambitious and popular franchise. There are over 200 motocross clubs across the country, permitting over 900 events annually.MethodData were collected prospectively over 4 years (from 2010 to 2014) at our unit. All injuries caused by motocross biking that were referred to our trauma and orthopaedic department were included in this study, regardless of whether the rider was performing the sport competitively or recreationally.ResultsDuring the period studied (4 years), 423 patients were included with a total of 485 injuries, ranging from 1 to 6 injuries per patient. The patient's age range was from 4 to 73 years, with most of the injuries being sustained within the early spring and summer months representing the start of the motocross season.ConclusionsWe present the first epidemiological study of motocross injuries in the UK. Within the growing culture of ‘adrenaline sports’, motocross has become an exhilarating and extremely fashionable pastime. This study has identified and categorised the spectrum of injuries from upper limb fracture dislocations to life-threatening head and chest injuries, some of which are serious and may cause significant morbidity and possible mortality. These injuries could have significant resource implications, especially for smaller rural hospitals.
Effect of Ramadan intermittent fasting on selective fitness profile parameters in young untrained Muslim men
Authors: Roy Anindita Singha , Bandyopadhyay Amit 
Published: November 2015

BackgroundThe present study was aimed at investigating the effects of sleep deprivation and dietary irregularities during Ramadan intermittent fasting (RIF) on selective fitness profile parameters in young untrained male Muslim individuals.Methods77 untrained Muslim men were recruited in the study. They were divided into the experimental group (EG; n=37, age: 22.62±1.77 years) and the control group (CG; n=40, age: 23.00±1.48 years). EG was undergoing RIF while CG abstained. Aerobic fitness, anaerobic capacity or high-intensity efforts (HIEs), agility, flexibility, vertical jump height and handgrip strength were measured on 8 separate occasions—15 days before RIF, 7 days before RIF, 1st day of RIF, 7th day of RIF, 15th day of RIF, 21st day of RIF, last day of RIF and 15 days after RIF.ResultsAerobic fitness and HIE showed a significant difference (p<0.05) during RIF in EG. Agility and flexibility score showed a significant decrease in EG during RIF, whereas changes in the vertical jump score (VJT) and handgrip strength were statistically insignificant. Studied parameters showed an insignificant variation in CG during RIF. Aerobic fitness, HIEs, agility and flexibility showed a significant intergroup variation during different experimental trials.ConclusionsThe present investigation revealed that RIF had adverse effects on aerobic fitness, HIEs, agility and flexibility of young untrained Muslims of Kolkata, India. VJT, waist-hip ratio and handgrip strength were not affected by RIF in the studied population. Mild but statistically insignificant reduction in body mass was also reflected after the mid-Ramadan week.
The challenge of preserving cardiorespiratory fitness in physically inactive patients with colon or breast cancer during adjuvant chemotherapy: a randomised feasibility study
Authors: Møller Tom , Lillelund Christian , Andersen Christina , Bloomquist Kira , Christensen Karl Bang , Ejlertsen Bent , Nørgaard Lone , Wiedenbein Liza , Oturai Peter , Breitenstein Ulla , Adamsen Lis 
Published: November 2015

IntroductionAnti-neoplastic treatment is synonymous with an inactive daily life for a substantial number of patients. It remains unclear what is the optimal setting, dosage and combination of exercise and health promoting components that best facilitate patient adherence and symptom management in order to support cardio-respiratory fitness and lifestyle changes in an at-risk population of pre-illness physically inactive cancer patients.MethodsPatients with breast or colon cancer referred to adjuvant chemotherapy and by the oncologists pre-screening verified as physically inactive were eligible to enter a randomised three-armed feasibility study comparing a 12-week supervised hospital-based moderate to high intensity exercise intervention or alternate an instructive home-based12-week pedometer intervention, with usual care.ResultsUsing a recommendation based physical activity screening instrument in order to correspond with cardio-respiratory fitness (VO2 peak) proved to be an applicable method to identify pre-illness physically inactive breast and colon cancer patients. The study demonstrated convincing recruitment (67%), safety and intervention adherence among breast cancer patients; while the attendance rate for colon cancer patients was notably lower (33%). VO2-peak declined on average 12% across study groups from baseline to 12 weeks though indices towards sustaining watt performance and reduce fat mass favoured the hospital-based intervention. Pedometer use was well adapted in both breast and colon cancer patients.ConclusionsDespite a fair adherence and safety, the current study calls into question whether aerobic exercise, regardless of intensity, is able to increase VO2-peak during texane-based chemotherapy in combination with Neulasta in physically inactive breast cancer patients.Trial Registration:ISRCTN24901641
Decrease in eccentric quadriceps and hamstring strength in recreational alpine skiers after prolonged skiing
Authors: Koller Arnold , Fuchs Birgit , Leichtfried Veronika , Schobersberger Wolfgang 
Published: November 2015

BackgroundTo effectively prevent injury in recreational alpine skiing, it is important to identify modifiable risk factors that can be targeted through exercise and training. Fatigue is a potential risk factor in recreational skiing, but no investigations have evaluated concentric/eccentric quadriceps and hamstring fatigue in recreational skiers. We tested the hypothesis that recreational skiing is associated with more pronounced eccentric as compared with concentric muscle fatigue.MethodsTwenty-four healthy and fit recreational skiers (14 male and 10 female) performed an isokinetic muscle test 1 day before, 1 h after, and 24 h after a 4 h skiing session. The testing protocol consisted of concentric and eccentric quadriceps and hamstring contractions for both legs.ResultsEccentric peak hamstring torque (both thighs) and eccentric peak quadriceps torque (left thigh) were reduced in male and female participants (p<0.05). Reduced peak torques were still present 24 h after the skiing session. There were no other significant findings.SummaryRecreational skiing is associated with prolonged (at least 24 h) eccentric quadriceps (left thigh) and hamstring (both thighs) fatigue in men and women. Eccentric quadriceps and hamstring fatigue may be a potential injury risk factor in male and female recreational skiers. This provides some justification for judicious use of additional eccentric training modalities for alpine skiing.
Effectiveness of a single platelet-rich plasma injection to promote recovery in rugby players with ankle syndesmosis injury
Authors: Samra David J , Sman Amy D , Rae Katherine , Linklater James , Refshauge Kathryn M , Hiller Claire E 
Published: November 2015

AimsTo determine whether a single ultrasound-guided platelet-rich plasma (PRP) injection into the anterior inferior tibiofibular ligament (AITFL) reduces the time for rugby athletes to return to function and match play following MRI confirmed ankle syndesmosis injury.MethodsCohort controlled pilot study. 10 Rugby Union players were recruited during the 2014 season, and consented to receive a single autologous PRP injection into the AITFL within 14 days of MRI confirmed ankle syndesmosis injury. A historical control group included 11 comparable Rugby Union players between 2011 and 2013 who were treated conservatively with the same inclusion criteria and rehabilitation protocol as the intervention group. Participants followed a standardised rehabilitation protocol involving simple milestones for progression. Early functional tests were performed 2 weeks after the removal of the CAM (controlled ankle motion) boot. Time to return to play was recorded. Repeat functional testing occurred within 1 week of return to play.ResultsGroups were comparable in anthropometrics, playing position and MRI injury severity. Time to return to play was significantly less in the intervention group (p=0.048). Following return to play, athletes in the intervention group showed higher agility (p=0.002) and vertical jump (p=0.001). There was a lower level of fear avoidance associated with rugby in the intervention group (p=0.014).ConclusionsThis pilot study shows that, following ankle syndesmosis injury, a single autologous PRP injection may accelerate safe and successful return to Rugby Union, with improved functional capacity and reduced fear avoidance. It demonstrates the feasibility of a randomised controlled trial to further assess this therapy.Trial registration numberANZCTRN12614000055606.
Mechanical efficiency improvement in relation to metabolic changes in sedentary obese adults
Authors: Jabbour Georges , Iancu Horia-Daniel 
Published: November 2015

PurposeMechanical efficiency (ME) refers to the ability of an individual to transfer energy consumed by external work. This performance indicator is impaired by obesity and is associated with decreased high-intensity exercise performance. However, it is unclear if ME may be improved in response to high intensity training (HIT). This study aimed to determine if ME increases in response to HIT in obese adults and to identify the factors associated with these changes.Methods24 obese adults (body mass index=∼33 kg/m2) were randomised into control (n=12) and trained (n=12) groups. Following baseline metabolic, anthropometric, fitness and ME measurements, the participants completed a 6-week exercise intervention that included 18 sessions of six repeats of 6 s supramaximal sprints on an electromagnetically braked cycle ergometer. The metabolic, anthropometric and fitness assessments were repeated postintervention. ME (expressed as a %) was calculated during an incremental maximal cycling test at stages of 25, 50, 75, 100 and 125 W.ResultsME did not differ across the groups at 25 and 50 W. Following HIT, ME increased significantly at 75, 100 and 125 W (p<0.01, respectively) compared with the control group (p<0.01, respectively). Although no changes in fat-free mass were observed following HIT, the increases in ME at 75, 100 and 125 W correlated positively with both homeostasis model assessment-estimated insulin resistance index decreases (r=0.9; r=0.89 and r=0.88, p<0.01, respectively) and peak power increases (r=0.87, r=0.88 and r=0.9, p<0.01, respectively).ConclusionsAlthough there were no changes in the participants’ anthropometric variables, HIT improved ME in obese adults, an enhancement that appears to be related to increases in muscle strength and metabolic adaptations.
Susceptibility to exertional heat illness and hospitalisation risk in UK military personnel
Authors: Stacey Michael J , Parsons Iain T , Woods David R , Taylor Peter N , Ross David , J Brett Stephen 
Published: November 2015

BackgroundSusceptibility to exertional heat illness (EHI) is considered multifactorial in nature. The aims of this study were to (1) review traditional susceptibility factors identified in cases of EHI and (2) determine how they are related to risk of hospitalisation.MethodsReview of an electronic database of EHI reported in the British Army between 1 September 2007 and 31 December 2014. Cases were categorised by demographic, situational and susceptibility variables. Univariate and multivariate logistic regression was performed for the OR for hospitalisation by risk factor.Results361 reports were included in the analysis. 33.5% of cases occurred in hot climates, 34.6% in temperate climates during summer months and 31.9% in temperate climates outside of summer months. Traditional susceptibility factors were reported in 193 but entirely absent from 168 cases. 137 cases (38.0%) were admitted to hospital. Adjusted OR for hospitalisation was lower for recruits (OR 0.42, 95% CI 0.18 to 0.99, p<0.05) and for personnel wearing occlusive dress (OR 0.56, 95% CI 0.34 to 0.93, p<0.05) or unacclimatised to heat (OR 0.31, 95% CI 0.15 to 0.66, p<0.01).ConclusionsThe global, year-round threat of EHI is highlighted. Absence of susceptibility factors in nearly half of reports highlights the challenge of identifying EHI-prone individuals. Paradoxical association of traditional susceptibility factors with reduced hospitalisation risk may reflect the contemporary contexts in which severe EHI occurs. These findings also suggest a need for better evidence to inform guidelines that aim to prevent severe EHI concurrent to reducing overall morbidity.
Intraplate seismicity in mid-plate South America: correlations with geophysical lithospheric parameters
Authors: Agurto-Detzel Hans , Assumpção Marcelo , Bianchi Marcelo , Pirchiner Marlon 
Published: November 2015

Abstract
Mid-plate South America remains one of the least-studied regions of intraplate seismicity. Little is known about the origin and controlling factors that make this area the least seismically active intraplate region in the world. We analysed the distribution of intraplate seismicity and its correlation with several geophysical lithospheric parameters in an attempt to establish which factors might promote or inhibit the occurrence of intraplate earthquakes. We found that above-average seismicity occurs mostly in Neoproterozoic fold belts, associated with areas having a positive gravity anomaly, lower elastic thickness, higher heat flow, thinned crust and a negative S-wave anomaly at 100 km depth (associated with non-cratonic crust). Cratonic areas with a higher elastic thickness and lower heat flow are associated with low rates of seismicity. Our study suggests that the most important controlling factors are elastic thickness and heat flow. We propose that earthquake-prone areas with these favourable conditions correspond to regions of weakened lithosphere, where most of the regional lithospheric stresses are supported by the overlying brittle upper crust. These areas act as local concentrators of the regional compressional stress field, with the stress build-up then leading to the occurrence of intraplate seismicity.

Supplementary material:
contains additional statistics and figures considering different filters for the used catalogue as a mean of comparison with the figures presented in the main text. They are available at
http://www.geolsoc.org.uk/SUP18872
Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Authors: Mazzieri Roberta , Pietrogrande Giovanni , Gerasi Laura , Gandelli Alessandro , Colombo Piergiuseppe , Moi Davide , Brombin Chiara , Ambrosi Alessandro , Danese Silvio , Mignatti Paolo , Blasi Francesco , D'Alessio Silvia 
Published: November 2015

Abstract
The urokinase-type plasminogen activator receptor (uPAR) has a well-established role in cancer progression, but it has been little studied at earlier stages of cancer initiation. Here, we show that uPAR deficiency in the mouse dramatically reduces susceptibility to the classical two-stage protocol of inflammatory skin carcinogenesis. uPAR genetic deficiency decreased papilloma formation and accelerated keratinocyte differentiation, effects mediated by Notch1 hyperactivation. Notably, Notch1 inhibition in uPAR-deficient mice rescued their susceptibility to skin carcinogenesis. Clinically, we found that human differentiated keratoacanthomas expressed low levels of uPAR and high levels of activated Notch1, with opposite effects in proliferating tumors, confirming the relevance of the observations in mice. Furthermore, we found that TACE-dependent activation of Notch1 in basal kerantinocytes was modulated by uPAR. Mechanistically, uPAR sequestered TACE within lipid rafts to prevent Notch1 activation, thereby promoting cell proliferation and tumor formation. Given that uPAR signaling is nonessential for normal epidermal homeostasis, our results argue that uPAR may present a promising disease-specific target for preventing skin cancer development. Cancer Res; 75(22); 4895–909. ©2015 AACR.
Amphiregulin Is a Critical Downstream Effector of Estrogen Signaling in ERα-Positive Breast Cancer
Authors: Peterson Esther A. , Jenkins Edmund C. , Lofgren Kristopher A. , Chandiramani Natasha , Liu Hui , Aranda Evelyn , Barnett Maryia , Kenny Paraic A. 
Published: November 2015

Abstract
Estrogen stimulation promotes epithelial cell proliferation in estrogen receptor (ERα)-positive breast cancer. Many ERα target genes have been enumerated, but the identities of the key effectors mediating the estrogen signal remain obscure. During mouse mammary gland development, the estrogen growth factor receptor (EGFR) ligand amphiregulin acts as an important stage-specific effector of estrogen signaling. In this study, we investigated the role of amphiregulin in breast cancer cell proliferation using human tissue samples and tumor xenografts in mice. Amphiregulin was enriched in ERα-positive human breast tumor cells and required for estrogen-dependent growth of MCF7 tumor xenografts. Furthermore, amphiregulin levels were suppressed in patients treated with endocrine therapy. Suppression of EGF receptor signaling appeared necessary for the therapeutic response in this setting. Our findings implicate amphiregulin as a critical mediator of the estrogen response in ERα-positive breast cancer, emphasizing the importance of EGF receptor signaling in breast tumor pathogenesis and therapeutic response. Cancer Res; 75(22); 4830–8. ©2015 AACR.
Androgen Receptor Modulation Optimized for Response (ARMOR) Phase I and II Studies: Galeterone for the Treatment of Castration-Resistant Prostate Cancer
Authors: Montgomery Bruce , Eisenberger Mario A. , Rettig Matthew B. , Chu Franklin , Pili Roberto , Stephenson Joseph J. , Vogelzang Nicholas J. , Koletsky Alan J. , Nordquist Luke T. , Edenfield William J. , Mamlouk Khalid , Ferrante Karen J. , Taplin Mary-Ellen 
Published: November 2015

Abstract
Purpose: Galeterone is a selective, multitargeted agent that inhibits CYP17, antagonizes the androgen receptor (AR), and reduces AR expression in prostate cancer cells by causing an increase in AR protein degradation. These open-label phase I and II studies [Androgen Receptor Modulation Optimized for Response-1 (ARMOR1) and ARMOR2 part 1] evaluated the efficacy and safety of galeterone in patients with treatment-naive nonmetastatic or metastatic castration-resistant prostate cancer (CRPC) and established a dose for further study.
Experimental Design: In ARMOR1, 49 patients received increasing doses (650–2,600 mg) of galeterone in capsule formulation; 28 patients in ARMOR2 part 1 received increasing doses (1,700–3,400 mg) of galeterone in tablet formulation for 12 weeks. Patients were evaluated biweekly for safety and efficacy, and pharmacokinetic parameters were assessed.
Results: In ARMOR1, across all doses, 49.0% (24/49) achieved a ≥30% decline in prostate-specific antigen (PSA; PSA30) and 22.4% (11/49) demonstrated a ≥50% PSA decline (PSA50). In ARMOR2 part 1, across all doses, PSA30 was 64.0% (16/25) and PSA50 was 48.0% (12/25). In the 2,550-mg dose cohort, PSA30 was 72.7% (8/11) and PSA50 was 54.5% (6/11). Galeterone was well tolerated; the most common adverse events were fatigue, increased liver enzymes, gastrointestinal events, and pruritus. Most were mild or moderate in severity and required no action and there were no apparent mineralocorticoid excess (AME) events.
Conclusions: The efficacy and safety from ARMOR1 and ARMOR2 part 1 and the pharmacokinetic results support the galeterone tablet dose of 2,550 mg/d for further study. Galeterone was well tolerated and demonstrated pharmacodynamic changes consistent with its selective, multifunctional AR signaling inhibition. Clin Cancer Res; 22(6); 1356–63. ©2015 AACR.