bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Use of Endoscopy for Transcervical Cannulation Procedures in the Goat
Authors: Colagross‐Schouten A , Allison D , Brent L , Lissner E 
Published: September 2014

ContentsTwo methods for transcervical cannulation of the goat were evaluated during a contraception study in 15 adult female Nigerian dwarf and African pygmy goats. Twenty‐four transcervical cannulation procedures were conducted in which seven females underwent the procedure 2–3 times. Initially, a rigid 4‐mm stainless steel cannula and external light source were used in 19 procedures to introduce the contraceptive compound into the uterus. Placement of the cannula was directed by feel or depth assessment. Of seven females that were euthanized following this procedure, four evidenced complications including penetration of the cervix with the cannula and cervical damage. A 2‐mm custom‐made endoscope with a specially designed cannula was then used for the remaining five procedures. No complications were found. A single animal, that underwent the endoscopic procedure twice, was euthanized for study purposes and no abnormal findings of the reproductive tract were reported. The use of an endoscope resulted in better outcomes because the uterus could be visualized after traversing the cervix.
Cryopreservation of Ram Semen in Extenders Containing Soybean Lecithin as Cryoprotectant and Hyaluronic Acid as Antioxidant
Authors: Najafi A , Najafi MH , Zanganeh Z , Sharafi M , Martinez‐Pastor F , Adeldust H 
Published: September 2014

ContentsA soybean lecithin‐based extender supplemented with hyaluronic acid (HA) was assayed for effectiveness to improve the quality of frozen–thawed ram semen. HA has not been tested yet in an extender containing soybean lecithin for freezing ram semen. Thus, the aim of this study was to analyse the effects of soybean lecithin at 1% or 1.5% along with HA at 0, 0.5 and 1 mg ml‐1 in a Tris‐based extender on the motion characteristics, membrane integrity (HOST), viability, GSH peroxidase (GSH‐PX) activity, lipid peroxidation and acrosomal status after freezing–thawing. Semen was collected from four Mehraban rams during the breeding season and frozen in the six lecithin×HA extenders. The extender containing 1.5% lecithin supplemented with no HA yielded higher total motility (52.5%±1.6), viability (55.8%±1.6) and membrane integrity (44.5%±1.7), but the effects of the lecithin concentration did not reach signification. Linearity‐related parameters, ALH, BCF, lipid peroxidation, GSH‐PX activity, morphology and acrosomal status were not affected by the extender composition. In general, adding HA significantly decreased sperm velocity (1 mg ml‐1 HA), total motility (only with 1.5% lecithin), viability (1 mg ml‐1 HA for 1% lecithin; both concentrations for 1.5% lecithin) and membrane integrity. In conclusion, adding HA to the freezing extender supplemented with soybean lecithin failed to improve quality‐related variables in ram semen. Increasing the lecithin content could have a positive effect, but further studies are needed.
Bilateral Sertoli and Interstitial Cell Tumours in Abdominal Testes of a Goat with Polled Intersex Syndrome (PIS)
Authors: Canisso IF , Coffee LL , Ortved K , Fubini SL , Monteagudo LV , Schlafer DH , Gilbert RO 
Published: September 2014

ContentsAn 8‐year‐old, mixed breed, polled goat was presented for evaluation of male‐like behaviour. Clinical findings included clitoromegaly, a heavily muscled neck, pronounced beard, and erect dorsal guard hairs, which are phenotypic characteristics commonly observed in intersex animals. Transrectal ultrasonography revealed the presence of two abdominal masses caudolateral to the uterine horns. Serum concentration of estradiol was elevated. Genetic evaluation was compatible with polled intersex syndrome defined by an XX karyotype without a Y chromosome or SRY gene. Based on gross and histologic evaluation, the abdominal masses were determined to be intra‐abdominal testes, each of which was effaced by Sertoli cell and interstitial (Leydig) cell tumours. The Sertoli cell tumours (SCTs) represented two unique histologic patterns. Regardless of pattern, neoplastic Sertoli cells were consistently lipid laden and positive for vimentin. Interstitial cell tumours (ICTs) were negative for vimentin. Clinical and histopathologic findings suggest that prolonged exposure to steroids secreted by neoplastic Sertoli cells contributed to virilization. In addition, results from immunohistochemistry indicated that vimentin may be a valuable immunodiagnostic tool for differentiation between interstitial and Sertoli cell tumours in goats.
Principles for Sustainable Insurance: Risk Management and Value
Authors: Scordis Nicos A. , Suzawa Yoshihiko , Zwick Astrid , Ruckner Lucia 
Published: September 2014

AbstractSome of the largest global insurers are actively pursuing the recently enacted Principles for Sustainable Insurance (PSI). While the concept of sustainability is often associated with a governance design that promotes stakeholder value, the PSI do not appear to be a call for stakeholder‐focused insurers. Rather, the PSI appear to be about internalizing tacit claims in the operations of insurers. Conceptual and empirical literature on shareholder value maximization suggests that when an insurer honors its tacit claims the value to shareholders increases. A key insight from practice is that a sincere pursuit of the PSI will expand the scope of corporate risk management.
Unitary cycles on Shimura curves and the Shimura lift II
Authors: Sankaran Siddarth 
Published: September 2014

AbstractWe consider two families of arithmetic divisors defined on integral models of Shimura curves. The first was studied by Kudla, Rapoport and Yang, who proved that if one assembles these divisors in a formal generating series, one obtains the$q$-expansion of a modular form of weight 3/2. The present work concerns the Shimura lift of this modular form: we identify the Shimura lift with a generating series comprising divisors arising in the recent work of Kudla and Rapoport regarding cycles on Shimura varieties of unitary type. In the prequel to this paper, the author considered the geometry of the two families of cycles. These results are combined with the Archimedean calculations found in this work in order to establish the theorem. In particular, we obtain new examples of modular generating series whose coefficients lie in arithmetic Chow groups of Shimura varieties.
Bifurcation to traveling waves in the cubic–quintic complex Ginzburg–Landau equation
Authors: Park Jungho , Strzelecki Philip 
Published: September 2014

We consider the one-dimensional complex Ginzburg–Landau equation which is a generic modulation equation describing the nonlinear evolution of patterns in fluid dynamics. The existence of a Hopf bifurcation from the basic solution was proved by Park [Bifurcation and stability of the generalized complex Ginzburg–Landau equation, Pure Appl. Anal. 7(5) (2008) 1237–1253]. We prove in this paper that the solution bifurcates to traveling waves which have constant amplitudes. We also prove that there exist kink-profile traveling waves which have variable amplitudes. The structure of the traveling waves is examined and it is proved by means of the center manifold reduction method and some perturbation arguments, that the variable amplitude traveling waves are quasi-periodic and they connect two constant amplitude traveling waves.
BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity
Authors: Cao Yuan , Slaney Clare Y. , Bidwell Bradley N. , Parker Belinda S. , Johnstone Cameron N. , Rautela Jai , Eckhardt Bedrich L. , Anderson Robin L. 
Published: September 2014

Abstract
The TGFβ growth factor family member BMP4 is a potent suppressor of breast cancer metastasis. In the mouse, the development of highly metastatic mammary tumors is associated with an accumulation of myeloid-derived suppressor cells (MDSC), the numbers of which are reduced by exogenous BMP4 expression. MDSCs are undetectable in naïve mice but can be induced by treatment with granulocyte colony-stimulating factor (G-CSF/Csf3) or by secretion of G-CSF from the tumor. Both tumor-induced and G-CSF–induced MDSCs effectively suppress T-cell activation and proliferation, leading to metastatic enhancement. BMP4 reduces the expression and secretion of G-CSF by inhibiting NF-κB (Nfkb1) activity in human and mouse tumor lines. Because MDSCs correlate with poor prognosis in patients with breast cancer, therapies based on activation of BMP4 signaling may offer a novel treatment strategy for breast cancer. Cancer Res; 74(18); 5091–102. ©2014 AACR.
REPLACE DARE (Death After Replacement Evaluation) Score
Authors: Chung Mina K. , Holcomb Richard G. , Mittal Suneet , Steinberg Jonathan S. , Gleva Marye J. , Mela Theofanie , Uslan Daniel Z. , Mitchell Kevin , Poole Jeanne E. 
Published: September 2014

Background—
Identifying factors predictive of mortality may be important to decrease risk associated with cardiac implantable electrical device (CIED) replacement procedures. This study aimed to determine whether clinical factors and complications independently associate with death and to develop a mortality risk prediction tool after CIED replacement.

Methods and Results—

The prospective REPLACE Registry determined 6-month complication and mortality rates after CIED replacement with or without planned lead addition or revision. Vital status was collected. Kaplan-Meier survival and multivariable Cox proportional hazards regression analyses were performed to identify patient, procedural, or complication variables predictive of death. The REPLACE DARE (Death After Replacement Evaluation) Score was constructed using hazard ratios, reflecting relative risk contributions of each variable, combined into an additive mortality risk score equation. At 6 months, 70 of 1744 (4.0%) patients had died. Cox regression analysis found no significant association between major complications and death. However, recent heart failure admission, New York Heart Association class III/IV, antiarrhythmic drug use, cerebrovascular disease, and chronic kidney disease stage were independently associated with 6-month mortality. The REPLACE DARE Score was 2.0±1.4 in survivors versus 3.5±1.8 in nonsurvivors (
P
<0.001), with predictive receiver operating characteristic value=0.758 (
P
<0.001). Risk of death was 1.0% for DARE=0 and 55.6% for DARE=7. The hazard ratio was 1.8 for each change of 1 DARE unit.

Conclusions—
Comorbidities, but not complications, were significantly associated with mortality after CIED replacement. The REPLACE DARE Score is a novel tool that can identify patients with substantial mortality risk. Such patients should have the relative risk and benefit of their procedure considered carefully.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00395447.
Electrical Storm Induced by Cardiac Resynchronization Therapy Is Determined by Pacing on Epicardial Scar and Can be Successfully Managed by Catheter Ablation
Authors: Roque Carla , Trevisi Nicola , Silberbauer John , Oloriz Teresa , Mizuno Hiroya , Baratto Francesca , Bisceglia Caterina , Sora Nicoleta , Marzi Alessandra , Radinovic Andrea , Guarracini Fabrizio , Vergara Pasquale , Sala Simone , Paglino Gabriele , Gulletta Simone , Mazzone Patrizio , Cireddu Manuela , Maccabelli Giuseppe , Della Bella Paolo 
Published: September 2014

Background—
The mechanism of cardiac resynchronization therapy (CRT)–induced proarrhythmia remains unknown. We postulated that pacing from a left ventricular (LV) lead positioned on epicardial scar can facilitate re-entrant ventricular tachycardia. The aim of this study was to investigate the relationship between CRT-induced proarrhythmia and LV lead location within scar.

Methods and Results—

Twenty-eight epicardial and 63 endocardial maps, obtained from 64 CRT patients undergoing ventricular tachycardia ablation, were analyzed. A positive LV lead/scar relationship, defined as a lead tip positioned on scar/border zone, was determined by overlaying fluoroscopic projections with LV electroanatomical maps. CRT-induced proarrhythmia occurred in 8 patients (12.5%). They all presented early with electrical storm (100% versus 39% of patients with no proarrhythmia;
P
<0.01), requiring temporary biventricular pacing discontinuation in half of cases. They more frequently presented with heart failure/cardiogenic shock (50% versus 7%;
P
<0.01), requiring intensive care management. Ventricular tachycardia was re-entrant in all. The LV lead location within epicardial scar was significantly more frequent in the proarrhythmia group (60% versus 9%
P
=0.03 on epicardial bipolar scar, 80% versus 17%
P
=0.02 on epicardial unipolar scar, and 80% versus 17%
P
=0.02 on any-epicardial scar). Ablation was performed within epicardial scar, close to the LV lead, and allowed CRT reactivation in all patients.

Conclusions—
CRT-induced proarrhythmia presented early with electrical storm and was associated with an LV lead positioning within epicardial scar. Catheter ablation allowed for resumption of biventricular stimulation in all patients.
Electrical Storm in Patients With Brugada Syndrome Is Associated With Early Repolarization
Authors: Kaneko Yoshiaki , Horie Minoru , Niwano Shinichi , Kusano Kengo F. , Takatsuki Seiji , Kurita Takashi , Mitsuhashi Takeshi , Nakajima Tadashi , Irie Tadanobu , Hasegawa Kanae , Noda Takashi , Kamakura Shiro , Aizawa Yoshiyasu , Yasuoka Ryobun , Torigoe Katsumi , Suzuki Hiroshi , Ohe Toru , Shimizu Akihiko , Fukuda Keiichi , Kurabayashi Masahiko , Aizawa Yoshifusa 
Published: September 2014

Background—
Electrical storms (ESs) in patients with Brugada syndrome (BrS) are rare though potentially lethal.

Methods and Results—

We studied 22 men with BrS and ES, defined as ≥3 episodes/d of ventricular fibrillation (VF) and compared their characteristics with those of 110 age-matched, control men with BrS without ES. BrS was diagnosed by a spontaneous or drug-induced type 1 pattern on the ECG in the absence of structural heart disease. Early repolarization (ER) was diagnosed by J waves, ie, >0.1 mV notches or slurs of the terminal portion of the QRS complex. The BrS ECG pattern was provoked with pilsicainide. A spontaneous type I ECG pattern, J waves, and horizontal/descending ST elevation were found, respectively, in 77%, 36%, and 88% of patients with ES, versus 28% (
P
<0.0001), 9% (
P
=0.003), and 60% (
P
=0.06) of controls. The J-wave amplitude was significantly higher in patients with than without ES (
P
=0.03). VF occurred during undisturbed sinus rhythm in 14 of 19 patients (74%), and ES were controlled by isoproterenol administration. All patients with ES received an implantable cardioverter defibrillator and over a 6.0±5.4 years follow-up, the prognosis of patients with ES was significantly worse than that of patients without ES. Bepridil was effective in preventing VF in 6 patients.

Conclusions—
A high prevalence of ER was found in a subgroup of patients with BrS associated with ES. ES appeared to be suppressed by isoproterenol or quinidine, whereas bepridil and quinidine were effective in the long-term prevention of VF in the highest-risk patients.
Weather–Climate Interactions in the Eastern Antilles and the 2013 Christmas Storm
Authors: Jury Mark R. 
Published: September 2014

Abstract
This study considers eastern Antilles (11°–18°N, 64°–57°W) weather and climate interactions in the context of the 2013 Christmas storm. This unseasonal event caused flash flooding in Grenada, St. Vincent, St. Lucia, Martinique, and Dominica from 24 to 25 December 2013, despite having winds &lt;15 m s−1. The meteorological scenario and short-term forecasts are analyzed. At the low level, a convective wave propagated westward while near-equatorial upper westerly winds surged with eastward passage of a trough. The combination of tropical moisture, cyclonic vorticity, and uplift resulted in rain rates greater than 30 mm h−1 and many stations reporting 200 mm. Although forecast rainfall was low and a few hours late, weather services posted flood warnings in advance. At the climate scale, the fresh Orinoco River plume brought into the region by the North Brazil Current together with solar radiation greater than 200 W m−2, enabled sea temperatures to reach 28°C, and supplied convective available potential energy greater than 1800 J kg−1. Climate change model simulations are compared with reference fields and trends are analyzed in the eastern Antilles. While temperatures are set to increase, the frequency of flood events appears to decline in the future.
Satellite Precipitation Data–Driven Hydrological Modeling for Water Resources Management in the Ganges, Brahmaputra, and Meghna Basins
Authors: Siddique-E-Akbor A. H. M. , Hossain Faisal , Sikder Safat , Shum C. K. , Tseng Steven , Yi Yuchan , Turk F. J. , Limaye Ashutosh 
Published: September 2014

Abstract
The Ganges–Brahmaputra–Meghna (GBM) river basins exhibit extremes in surface water availability at seasonal to annual time scales. However, because of a lack of basinwide hydrological data from in situ platforms, whether they are real time or historical, water management has been quite challenging for the 630 million inhabitants. Under such circumstances, a large-scale and spatially distributed hydrological model, forced with more widely available satellite meteorological data, can be useful for generating high resolution basinwide hydrological state variable data [streamflow, runoff, and evapotranspiration (ET)] and for decision making on water management. The Variable Infiltration Capacity (VIC) hydrological model was therefore set up for the entire GBM basin at spatial scales ranging from 12.5 to 25 km to generate daily fluxes of surface water availability (runoff and streamflow). Results indicate that, with the selection of representative gridcell size and application of correction factors to evapotranspiration calculation, it is possible to significantly improve streamflow simulation and overcome some of the insufficient sampling and data quality issues in the ungauged basins. Assessment of skill of satellite precipitation forcing datasets revealed that the Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA) product of 3B42RT fared comparatively better than the Climate Prediction Center (CPC) morphing technique (CMORPH) product for simulation of streamflow. The general conclusion that emerges from this study is that spatially distributed hydrologic modeling for water management is feasible for the GBM basins under the scenario of inadequate in situ data availability. Satellite precipitation forcing datasets provide the necessary skill for water balance studies at interannual and interseasonal scales. However, further improvement in skill may be required if these datasets are to be used for flood management at daily to weekly time scales and within a data assimilation framework.
An Exploration of Multivariate Fluctuation Dissipation Operators and Their Response to Sea Surface Temperature Perturbations
Authors: Fuchs David , Sherwood Steven , Hernandez Daniel 
Published: September 2014

Abstract
The fluctuation–dissipation theorem (FDT) has been proposed as a method of calculating the mean response of the atmosphere to small external perturbations. This paper explores the application of the theory under time and space constraints that approximate realistic conditions. To date, most applications of the theory in the climate context used univariate, low-dimensional-state representations of the climate system and an arbitrarily long sample size.
The authors explore high-dimensional multivariate FDT operators and the lower bounds of sample size needed to construct skillful operators. It is shown that the skill of the operator depends on the selection of variables and features representing the climate system and that these features change once memory (slab ocean) is added to the system.
In addition, it is found that the FDT operator has skill in estimating the response to realistic sea surface temperature (SST) patterns, such as El Niño–Southern Oscillation (ENSO), despite the fact that these patterns were not part of the data used to produce the operator. The response of clouds is also studied; for variables that represent cloud properties, the decrease in skill in relation to decrease in sample size still maintains the key features of the response.
Three-Dimensional Structure and Evolution of the Vertical Velocity and Divergence Fields in the MJO
Authors: Adames Ángel F. , Wallace John M. 
Published: September 2014

Abstract
The features in the planetary-scale wind field that shape the MJO-related vertical velocity field are examined using the linear analysis protocol based on the daily global velocity potential field described in a companion paper, augmented by a compositing procedure that yields a more robust and concise description of the prevalent patterns over the Indo-Pacific warm pool sector (60°E–180°). The analysis elucidates the structural elements of the planetary-scale wind field that give rise to the characteristic “swallowtail” shape of the region of enhanced rainfall and the “bottom up” evolution of the vertical velocity profile from one with a shallow peak on the eastern end of the region of enhanced rainfall to one with an elevated peak on the western end. These distinctive features of the vertical velocity field in the MJO reflect the juxtaposition of deep overturning circulation cells in the equatorial plane and much shallower frictionally driven cells in the meridional plane to the east and west of the regions of enhanced rainfall. The zonal overturning circulations determine the pattern of ∂u/∂x and the meridional overturning circulations determine the pattern of ∂υ/∂y in the divergence profiles. These features are at least qualitatively well represented by the Matsuno–Gill solution for the planetary wave response to a stationary equatorial heat source–sink dipole.
Advanced Two-Moment Bulk Microphysics for Global Models. Part I: Off-Line Tests and Comparison with Other Schemes
Authors: Gettelman A. , Morrison H. 
Published: September 2014

Abstract
Prognostic precipitation is added to a cloud microphysical scheme for global climate models. Results indicate very similar performance to other commonly used mesoscale schemes in an offline driver for idealized warm rain cases, better than the previous version of the global model microphysics scheme with diagnostic precipitation. In the mixed phase regime, there is significantly more water and less ice, which may address a common bias seen with the scheme in climate simulations in the Arctic. For steady forcing cases, the scheme has limited sensitivity to time step out to the ~15-min time steps typical of global models. The scheme is similar to other schemes with moderate sensitivity to vertical resolution. The limited time step sensitivity bodes well for use of the scheme in multiscale models from the mesoscale to the large scale. The scheme is sensitive to idealized perturbations of cloud drop and crystal number. Precipitation decreases and condensate increases with increasing drop number, indicating substantial decreases in precipitation efficiency. The sensitivity is less than with the previous version of the scheme for low drop number concentrations (Nc &lt; 100 cm−3). Ice condensate increases with ice number, with large decreases in liquid condensate as well for a mixed phase case. As expected with prognostic precipitation, accretion is stronger than with diagnostic precipitation and the accretion to autoconversion ratio increases faster with liquid water path (LWP), in better agreement with idealized models and earlier studies than the previous version.