bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamical behaviors of vector localized wave solutions for the coupled modified Korteweg-de Vries equations
Authors: Chen Yi-Xin , Wang YuFeng , Yang ShengXiong , Zhang Xi , Gao YiTian 
Published: July 2024

Abstract

Under investigation in this paper is the coupled modified Korteweg-de Vries equations. Based on Lax pair and Darboux transformation, various vector localized wave solutions are derived and analyzed. We notice that the localized waves have different dynamical behaviors in several components, for example, the bell-shaped soliton and flat-top soliton, or the bell-shaped soliton and two-peak soli-ton, are obtained in two components, respectively. Furthermore, the interactions between two solitons are different in distinct components. In addition, the vector breather and rogue wave solutions are constructed. Especially, the various structures of first-order rogue waves are observed, such as the two-peak rogue waves and flat-top rogue wave, or the dark rogue waves and bright rogue waves. Finally , the vector second-order rogue wave solutions are derived and the strong or weak interaction patterns of second-order rogue waves are achieved.
Downregulation of TMTC4 expression is associated with improved prognosis in sarcoma
Authors: Li Zihan , Tian Yihao 
Published: July 2024

Abstract

Osteosarcoma is the most common bone tissue tumor. The expression of Transmembrane and Tetratricopeptide Repeat Containing 4 (TMTC4) in osteosarcoma has never been reported. Therefore, the purpose of this study is to study the significance of TMTC4 in the prognosis of sarcoma. Screening the expression level of downstream genes after interleukin-11 receptor alpha (IL11RA) knockout in osteosarcoma through Gene Expression Synthesis (GEO) database. Use The Cancer Genome Atlas (TCGA) database and cloud data to further analyze the expression level and influence of TMTC4 in sarcoma and subgroup analysis. PCR was used to detect the expression level of TMTC4 among human osteoblast hFOB1.19 and human Osteosarcoma cells MG-63, U2OS and Saos-2, and CCK-8 was used to detect cell proliferation levels. Through GSE191215 database, 11 down-regulated genes such as TMTC4 were screened. KM curve shows that sarcomas with low TMTC4 expression level can show higher survival rate. The results of enrichment analysis showed that the low expression level of TMTC4 might be related to IMMUNOREGULATORY and ANTIGEN_ ACTIVATES. Methylation analysis showed that the methylation level of TMTC4 was increased in sarcomas. In addition, the expression level of TMTC4 in the Osteosarcoma group (MG-63, U2OS, Saos-2) was significantly higher than in hFOB1.19 and inhibition of TMTC4 expression impedes Osteosarcoma cell proliferation. Our results show that TMTC4 is an important biomarker in patients with sarcoma, and its low expression level is related to the improvement of the prognosis of sarcoma.
Compared with PA, DAA can improve bone mineral density and postoperative gait recovery：Retrospective study
Authors: Lou Xiulong , Chen Penglei , Ji RuiQing , Shen Jing , Chen Jie , Ge Yuying , Ji Weifeng 
Published: July 2024

Abstract

Background
To investigate the difference of bone mineral density and gait in patients with direct anterior approach and posterior approach after total hip arthroplasty was compared, and the correlation between bone density and gait was observed.
Methods
A total of 76 patients diagnosed with femoral head necrosis and completed the first unilateral total hip arthroplasty from October 2021 to March 2022 were enrolled as the study subjects, and were divided into two groups according to different surgical methods. The gait indexes and bone density in Gruen1 and 7 regions were analyzed retrospectively.
Results
Gait indexes of DAA group and PA group were significantly improvedmafter surgery compared with those before surgery; bone mineral density (BMI) at 1 month and 3 months after surgery in Gruen1 area was significantly improved compared with that in 1 week after surgery. Stride length, stride speed, stride frequency, percentage of single support phase of affected limb to gait cycle, hip motion and BMI at 1 month and 3 months after surgery in DAA group were all better than those in posterior approach group, and the differences were statistically significant (P < 0.05); there was a positive correlation between the gait indexes and BMI at 1 month and 3 months after operation in both the anterior and posterior approach groups (r > 0 ,P < 0.05).
Conclusion
Total Hip Arthroplasty(THA) with DAA has certain advantages in the postoperative functional rehabilitation of patients, which can improve the bone density of patients and improve the postoperative gait recovery of patients.
Modulation of Plet1 Expression by N-Acetylglucosamine through the IL-17A- MAPK Pathway in an Imiquimod-Induced Psoriasis Mouse Model
Authors: Selvakumar Balachandar , Rah Bilal , Sekar Priyadarshini , Jagal Jayalakshmi , Moustafa Raneem , Ramakrishnan Rakhee Kizhuvappat , Haider Mohamed , Ibrahim Saleh Mohamed , Samsudin Rani 
Published: July 2024

Abstract

Psoriasis (Ps) is a chronic inflammatory disorder marked by skin plaque formation, driven by immune dysregulation and genetic factors. Despite the available treatments, the incidence of Ps is increasing in the dermatology patients. Novel strategies are crucial due to treatment limitations. The interleukin 17 (IL-17) pathway is pivotal in Ps pathogenesis, yet the expression of its putative target gene placenta expressed transcript 1 (Plet1) remains unstudied in Ps. Considering the potential anti-inflammatory properties of N-Acetylglucosamine (GlcNAc), our study explored its role in modulating Plet1 expression in an Imiquimod (IMQ)-induced Ps mouse model. Our data demonstarted a significant reduction of inflammation and Psoriasis Area and Severity Index (PASI) scores, downregulation of growth factors, IL-17A, and MAPK expression after GlcNAc treatment. In addition, GlcNAc treatment reduced neutrophils, monocyte-dendritic cells (Mo-DC) and conventional T cells (Tcons) while increasing monocyte-macrophages (Mo-Macs) and regulatory T cells (Tregs). GlcNAc treatment also downregulated Plet1 overexpression in Psoriatic mouse skin and in vitro, reduced proliferation and apoptosis in IL-17A stimulated human dermal fibroblasts (HDF), along with IL-17A and TGF-β mRNA expression. Together, these data suggest that, GlcNAc interferes with downstream mechanisms in IL-17 pathway and downregulating Plet1 expression, presenting a promising strategy for Ps treatment.
DNA methylation analysis of SCD2, SEPT9 and VIM genes for the early detection of colorectal cancer in fecal DNA
Authors: Liu Yue , Ming Hongbo , Xu Lizhi , Li Lizhen , Liu Qi , Zhao Jinyin , Zhong Cundi , Li Hongzhi 
Published: July 2024

Abstract

Background
Colorectal cancer (CRC) is one of the most common cancers worldwide, with increasing mortality and morbidity. DNA methylation sites may serve as a new genes signature for early diagnosis. The search for representative DNA methylation sites is urgently needed. This study aimed to systematically identify a methylation gene panel for CRC using tissue and fecal samples.
Methods
A total of 181 fecal and 50 tumor tissue samples were collected. They were obtained from 83 CRC patients and 98 healthy subjects. These samples were evaluated for DNA methylation analyzing of 9 target genes by quantitative bisulfite next-generation sequencing. We employed the Rank-sum test to screen the CRC-specific methylation sites in the tissue and stool cohort. Subsequently, a data model was constructed and validated using the dedicated validation dataset.
Results
For all the selected gene sites, CRC tissue samples showed significantly higher methylation rates than fecal and negative controls samples. Methylation rates of tissue and preoperative fecal samples showed the same high and low rates at the same sites. After screening, a panel of 29 locus in the genes SCD2, SEPT9, and VIM proved a reliable biomarker for CRC detection in fecal samples. Logistic regression models were then constructed and validated using this panel. Sensitivity of the model is 91.43% (95% CI=[89.69, 93.17]) and specificity is 100% (95% CI=[100,100]). This confirms the validity of the screened panel to effectively detect CRC via feces.
Conclusions
Our study identifies a set of key methylation sites for the detection of CRC from fecal samples, highlighting the significance of using tissue and fecal samples to accurately assess DNA methylation levels to screen for methylation sites and developing an effective model for early detection of CRC.
There is a 7% risk that the first ice-free day in the Arctic Ocean could occur before 2030
Authors: Heuzé Céline , Jahn Alexandra 
Published: July 2024

Abstract

The observed Arctic sea ice decline is predicted to continue until ‘ice-free’ conditions are reached in the September monthly mean (sea ice area <1 million km2), which is likely to occur by 2050. Aside from being a symbol of ongoing anthropogenic climate change, an ice-free Arctic Ocean will have far-reaching consequences, from the local food web and global climate system to economics and geopolitics. So far all ice-free projection studies have been focused on monthly-mean ice-free conditions. However, the first time we will observe a sea ice area <1 million km2 will be in the daily satellite data. Using daily output from multiple CMIP6 models, we here provide the first projections of when we could see the first ice-free day in the Arctic Ocean. We find that there is a large range of the projected first ice-free day, ranging from 3 years compared to a 2023-equivalent model state (daily sea ice area minimum equal or larger than 3.39 million km2) to no ice-free day before the end of the simulation in 2100, depending on the model and forcing scenario used. Using a storyline approach, we here focus on the nine CMIP6 simulations where the first ice-free day occurs within 3-6 years, i.e. potentially before 2030, to understand what could cause such a rapid transition to first ice-free conditions. We find that these early ice-free days all occur during a rapid ice loss event, and are associated with winter and spring warming. During the final year, all simulations with early ice-free days are exceptionally warm, with storms further aiding the break-up of sea ice until ice-free conditions are reached.
Impact of hepatocellular cancer screening on early diagnostics and overall survival: own data
Authors: Petkau V. V. , Bessonova E. N. , Tarkhanov A. A. , Kartashov M. V. , Anashkina M. A. 
Published: July 2024

Introduction. An increase in the life expectancy of patients with HCC can be achieved both by improving treatment methods and by implementing early examination through screening programs.Aim. Evaluation of the impact of screening in risk groups on early detection of HCC, on the possibility of specialized treatment, on one-year overall survival of patients with HCC.Materials and methods. The clinical records of 148 patients with HCC and liver cirrhosis (LC) who received medical care at the Sverdlovsk Regional Oncology Center in 2022 with the follow-up period exceeding 12 months were retrospectively studied. HCC was diagnosed as a result of screening carried out on the basis of the Regional Hepatological Center in 34 patients. 114 patients were referred to the oncological hospital due to the detection of a malignant tumor in liver during examination in cause of complaints. The compared groups of patients did not differ in age and sex composition, in the frequency of smoking, alcohol consumption, drug addiction, viral hepatitis B, obesity, diabetes mellitus, arterial hypertension, oncological heredity, in the distribution of LC by class. Patients with HCC detected at screening had a better general somatic status (p < 0.001), more often had viral hepatitis C (82.4% vs. 35.1%, p < 0.001) and AFP above normal (64.7% vs. 43.0%, p = 0.027).Results. Screening influenced the staging of newly diagnosed patients with HCC. If the proportion of stages B and C according to the Barcelona system remained the same, then stage A accounted for 32.4% versus 12.3% (OR = 3.42; 95% CI 1.37–8.49; p = 0.007). Stage D, on the contrary, was less: 8.8% vs. 36.8% (OR = 0.17; 95% CI 0.05–0.58; p = 0.002). Identification at earlier stages and better general condition of patients influenced the possibilities and results of treatment. In the HCC group after screening more patients received treatment: 88.2% versus 56.1% (OR = 5.86; 95% CI 1.94–17.73; p < 0.001). There was a higher one-year overall survival: 79.4% vs 39.5% (OR = 5.91; 95% CI 2.38–14.73; p < 0.001).Conclusion. Screening for HCC in risk groups improves early diagnosis, increases the likelihood of patients receiving specialized anticancer treatment and increases the one-year overall survival rate.
Climate change and adaptive capacity in the community of Diaguitas, Chile: A descriptive-comparative vision in two time periods
Authors: Salas-Bravo Sonia , Araya-Piñones Angelo 
Published: July 2024

ABSTRACT

Water scarcity is a phenomenon that has generated great concern today. The drought scenario has particularly affected rural communities in the semi-arid region of northern Chile socially, economically, and environmentally as they try to adapt to climate change. This article focuses on the description and comparison of the institutional adaptive capacity of the Chilean community of Diaguitas to adapt to the effects on water resources and extreme events during two periods of time (2004–2007 and 2018–2019). This qualitative study considered the administration of interviews, field observations, and focus groups using the adaptive capacity wheel as a methodological basis. The results show differences in the ability to adapt between the two periods studied with most of the adaptive dimensions at a neutral or no effect level and the emergence of a new dimension of social capital. It was concluded that the adaptive capacity of the Diaguitas might have improved over time, influenced by the increased awareness of the consequences of climate change and the establishment of supportive institutions. It is necessary to incorporate new perspectives into water management, such as indigenous knowledge and collaborative resource management.
Climatic teleconnection of the future trend of meteorological, GRACE-DSI, and vegetation-conditioned-based drought analysis in the Ganga Basin
Authors: Hasan Mohd Sayeed Ul , Akhtar Nadeem , Rai Abhishek Kumar , Amir Khan Mohd , Alfaisal Faisal M. , Alharbi Raied Saad , Hashim Khalid S. 
Published: July 2024

ABSTRACT
This study assesses drought in the Ganga River Basin using standard precipitation index (SPI), Gravity Recovery and Climate Experiment Drought Severity Index (GRACE-DSI), and vegetation condition index (VCI) via geographic information system (GIS) and non-parametric tests. Future SPI trends show increasing drought severity from 1986 to 2020. GRACE-DSI analysis (2002–2020) indicates a potential rise in drought conditions. VCI computations reveal vegetation health dynamics. Findings suggest an impending severe drought in the Ganga Basin, necessitating urgent water resource management. Drought causes are linked to precipitation changes and resource over-exploitation in changing climate conditions. The study emphasizes implementing measures like water conservation, sustainable land use, and groundwater recharge strategies to mitigate drought impacts.
Optimizing wastewater treatment through artificial intelligence: recent advances and future prospects
Authors: Nagpal Mudita , Siddique Miran Ahmad , Sharma Khushi , Sharma Nidhi , Mittal Ankit 
Published: July 2024

ABSTRACT

Artificial intelligence (AI) is increasingly being applied to wastewater treatment to enhance efficiency, improve processes, and optimize resource utilization. This review focuses on objectives, advantages, outputs, and major findings of various AI models in the three key aspects: the prediction of removal efficiency for both organic and inorganic pollutants, real-time monitoring of essential water quality parameters (such as pH, COD, BOD, turbidity, TDS, and conductivity), and fault detection in the processes and equipment integral to wastewater treatment. The prediction accuracy (R2 value) of AI technologies for pollutant removal has been reported to vary between 0.64 and 1.00. A critical aspect explored in this review is the cost-effectiveness of implementing AI systems in wastewater treatment. Numerous countries and municipalities are actively engaging in pilot projects and demonstrations to assess the feasibility and effectiveness of AI applications in wastewater treatment. Notably, the review highlights successful outcomes from these initiatives across diverse geographical contexts, showcasing the adaptability and positive impact of AI in revolutionizing wastewater treatment on a global scale. Further, insights on the ethical considerations and potential future directions for the use of AI in wastewater treatment plants have also been provided.
Metal–organic framework-derived carbon-based evaporator for activating persulfate to remove phenol in interfacial solar distillation
Authors: Wang Yasheng , Huang Lei , Zhou Yawen , Yang Bing , Yu Zhixuan , Zhang Zhuoyang , Xu Chenmin , Yang Shaogui 
Published: July 2024

ABSTRACT

The migration of semi-volatile organic compounds (SVOCs), such as phenolic pollutants, during the interfacial solar distillation process is a serious threat to the safety of water quality. Sulfate radicals-based advanced oxidation process is introduced into interfacial solar distillation for SVOCs removal. In this work, metal organic frameworks (MOFs)-derived carbon coated iron material (Fe@C) decorated carbon evaporators with high Fenton-like catalytic performance were prepared by calcination of iron based-MOFs on metasequoia wood blocks. The results indicate that the MOFs-derived Fe@C-700 evaporator has a carbon-coated iron structure with abundant active sites. In the Fe@C-700/ peroxydisulfate (PDS) /light system, the removal rate of phenol (0.30 mmol/L) reached 95%, and only 5.7% of phenol transfer to distillation water after 240 minutes. Free radical trapping experiments and electron paramagnetic resonance (EPR) measurements confirmed the presence of both radical and non-radical pathways in the system with 1O2 and O2•− being the main active species. This work provides a feasible solution for designing iron-based catalysts based on MOFs for interfacial solar distillation process, and also discusses the synergistic effect between interfacial solar distillation and persulfate activation for achieving high-quality distilled water.
The Lingual Foramen Variations Detected on Cone Beam Computed Tomography (CBCT) Volumes: a Retrospective Radiographic Study
Authors: Abu-Ta’a Mahmoud F. , Beshtawi Khaled R. 
Published: July 2024

Objective
This study aims to investigate the anatomical variations of lingual foramina detected on cone beam computed tomography (CBCT) volumes in a sample of the Palestinian population seeking dental implant treatment.

Methods
A retrospective radiographic study was conducted on patients’ CBCT volumes. The lingual foramina (LF) number, direction (e.g., superior median [SMLF], horizontal median [HMLF], and inferior superior median [IMLF]), height (LH), width (LW) and length (LL) were recorded on CBCT views. Distances from the buccal and lingual aspects of the lingual foramina to the superior and inferior aspects of the alveolar ridge were measured. Moreover, the presence of lateral lingual foramina was also examined. Statistical significance in the differences and relationships of the variables was tested using several statistical tests. The intraclass correlation coefficient (ICC) was used to analyze intra- and interobserver agreement.

Results
One hundred and nineteen patients were analyzed. 78.99% of patients presented with one lingual foramen,17.65% and 3.36% with two and three canals, respectively. The measurements LH, LW, and ML were, on average, 0.64mm,0.8mm, and 7.06mm, respectively. The LH, LL, and LW showed a statistical difference when compared for different lingual foramina directions.

Conclusion
Among the analyzed sample, the majority of the lingual canals were single and pointing upward. Few individuals had lateral lingual canals visible. A careful assessment utilizing cross-sectional views is strongly advised to analyze the lingual canal’s structure and rule out any potential anatomical variation.
Studi Alternatif Penjadwalan Pelaksanaan Pekerjaan Bangunan Utama (Main Dam) Dan Pengelak/Terowongan Bendungan Ladongi, Kec. Ladongi, Kab. Kolaka Timur, Prov. Sulawesi Tenggara Menggunakan Microsoft Project Manager 2016
Authors: Pangestu Ihsan Dwi , Pitojo Tri Juwono  , Jadfan Sidqi Fidari  
Published: July 2024

Dalam suatu pekerjaan terutama pada proyek pekerjaan Bendungan pasti memiliki batasan waktu dan biaya yang telah di tentukan, maka dari itu dibutuhkan perencanaan manajemen konstruksi untuk mengatasi masalah yang terjadi pada suatu pekerjaan. Pada studi ini penulis bertujuan untuk menganalisa penjadwalan pada proyek Bendungan Ladongi pada pekerjaan Main Dam dan Pengelak dengan menggunakan program Microsot Project 2016. Alternatif utama yang di gunakan ialah dengan penambahan jam kerja dan penambahan alat berat, di sertai dengan beberapa metode yaitu PERT (Program Evaluation Review Technique), CPM (Crictical Path Method) dan Gannt Chart. Metode berikut merupakan metode yang dapat mempermudah analisa alternatif dan data pekerjaan dalam program. Data dari Kontraktor yang merupakan analisa untuk pekerjaan yang berupa data perencanaan, data harga satuan, dan data kontrak. Output dari alternatif adalah kurva S dengan bantuan program untuk mempermudah perbandingan antara penambahan durasi jam kerja dan jumlah alat berat. Hasil analisa pada studi ini di dapatkan durasi normal proyek selama 1410 hari. Hasil optimal dari alternatif adalah dengan menggunakan alternatif penambahan jam kerja dengan penurunan rencana anggaran biaya sebesar 1,89% dan mengalami percepatan durasi sebesar 13.48%.
Silaba tonis dalam intonasi bahasa Indonesia pada penutur Pandhalungan
Authors: Habib Habib Rois , Henry Yustanto  , Agus Hari Wibowo  
Published: July 2024

Karakteristik prosodi pada setiap penutur memiliki perbedaan, salah satunya disebabkan oleh mother tongue (B1). Unsur prosodi yang merujuk pada nada tuturan dapat direpresentasikan melalui intonasi. Visualisasi intonasi setiap penutur sulit untuk diketahui secara pasti, namun memiliki pola dasar yang sama dalam satu kelompok tutur. Tujuan dalam penelitian ini adalah mendeskripsikan karakteristik intonasi tonic syllable bahasa Indonesia pada penutur Pandhalungan dan menentukan apakah terdapat perbedaan komponen akustik silaba tonis pada kalimat deklaratif dan interogatif berdasarkan variabel B1. Penelitian ini merupakan penelitian eksperimental dengan menggunakan ancangan IPO. Data yang digunakan berupa rekaman audio (wav) setiap responden tepatnya pada kalimat deklaratif dan interogatif pola S-P, S-P-O, dan S-P-O-K. Sumber data dalam penelitian ini berasal dari partisipan yang berdomisili di Kecamatan Kaliwates dan Kecamatan Sumbersari, Kabupaten Jember. Teknik sampling yang digunakan dalam penelitian ini adalah purposive sampling dengan jenis sampel non probability. Tahapan analisis dalam penelitian ini meliputi (1) pemberian kode data; (2) anotasi tuturan; (3) konversi nilai komponen akustik; dan (4) uji signifikansi. Hasil analisis dalam penelitian ini menunjukkan bahwa silaba tonis pada suatu kata dapat berubah secara struktur maupun secara akustik, jika digunakan dalam modus kalimat yang berbeda. Silaba tonis [pa?] pada awal kalimat memiliki struktur dan karakteristik akustik yang serupa dengan interval f0 260 Hz - 320 Hz. Sementara silaba tonis yang berada di tengah kalimat maupun di akhir kalimat dapat berubah bentuk serta memiliki perbedaan komponen akustik secara signifikan dilihat dari variabel B1. Berdasarkan hasil analisis tersebut, dapat disimpulkan bahwa silaba tonis dalam intonasi bahasa Indonesia pada penutur Pandhalungan memiliki struktur yang bervariasi dengan adanya stress pada silaba tertutup kata awal atau kata akhir dalam modus kalimat.