bluuebunny/crossref_metadata_2025_split huggingface dataset:
Language centre teachers as researchers: The case of Finland
Authors: Rontu Heidi , Tuomi Ulla-Kristiina 
Published: October 2015

AbstractLanguage centres in higher education are facing new challenges as they plan curricula for an increasingly diverse student body and undertake new tasks in support of the multiform internationalisation of universities. Continuing professional development clearly needs to be taken to a new level, and one way of doing this is to include research in a more systematic way. In this article, we focus on the role of research as an aspect of the development of a language centre and on human resources development in particular. Based on recent data from university language centres in Finland, we report language centre personnel’s views on research in relation to their work. The results show that they are strongly in favour of developing their professional practice by engaging in research and that they feel that research conducted in language centres should be practical and have a direct relation to the other work of language centres. We also discuss different ways of supporting a research orientation and present practical models for implementing this in the development of work.
The Applicability Of SWE In Polish Spatial Data Infrastructures - The Example Of The SensorML Language
Authors: Rossa Maciej , Rogulski Mariusz 
Published: October 2015

Abstract
Mobile and stationary sensors currently used to measure various environmental parameters, functioning independently or as part of monitoring networks and measurement stations, provide vast amounts of data on the state and quality of the environment on the Earth. If the data is to be used effectively, they must be exchanged and shared among IT systems. Systems which offer services of searching, exchange, sharing, visualisation and analysis of dispersed and varied data resources on the widely understood environment are, for example, spatial data infrastructures.
The article presents an overview of IT technologies and standards which offer interoperability in spatial data infrastructures. It first defines interoperability and then describes the most important issues connected with spatial data infrastructures on the example of INSPIRE. An example standard which facilitates interoperability in INSPIRE is the SensorML language, a component of Sensor Web Enablement (SWE). Its practical application is proposed – for description of processes of air monitoring in a spatial data infrastructure that is an element of the Polish national environmental monitoring plan.
Energy Aware Cluster Based Routing Scheme For Wireless Sensor Network
Authors: Roy Sohini 
Published: October 2015

Abstract
Wireless Sensor Network (WSN) has emerged as an important supplement to the modern wireless communication systems due to its wide range of applications. The recent researches are facing the various challenges of the sensor network more gracefully. However, energy efficiency has still remained a matter of concern for the researches. Meeting the countless security needs, timely data delivery and taking a quick action, efficient route selection and multi-path routing etc. can only be achieved at the cost of energy. Hierarchical routing is more useful in this regard. The proposed algorithm Energy Aware Cluster Based Routing Scheme (EACBRS) aims at conserving energy with the help of hierarchical routing by calculating the optimum number of cluster heads for the network, selecting energy-efficient route to the sink and by offering congestion control. Simulation results prove that EACBRS performs better than existing hierarchical routing algorithms like Distributed Energy-Efficient Clustering (DEEC) algorithm for heterogeneous wireless sensor networks and Energy Efficient Heterogeneous Clustered scheme for Wireless Sensor Network (EEHC).
Real Time Recognition Of Speakers From Internet Audio Stream
Authors: Weychan Radoslaw , Marciniak Tomasz , Stankiewicz Agnieszka , Dabrowski Adam 
Published: October 2015

Abstract
In this paper we present an automatic speaker recognition technique with the use of the Internet radio lossy (encoded) speech signal streams. We show an influence of the audio encoder (e.g., bitrate) on the speaker model quality. The model of each speaker was calculated with the use of the Gaussian mixture model (GMM) approach. Both the speaker recognition and the further analysis were realized with the use of short utterances to facilitate real time processing. The neighborhoods of the speaker models were analyzed with the use of the ISOMAP algorithm. The experiments were based on four 1-hour public debates with 7–8 speakers (including the moderator), acquired from the Polish radio Internet services. The presented software was developed with the MATLAB environment.
NLRs Challenge Impacts Tight Junction Claudins In Sertoli Cells
Authors: Hayrabedyan Soren B. , Zasheva Diana Y. , Todorova Krassimira O. 
Published: October 2015

Abstract
Aim: The present study aims to investigate the NALP3 system and its effect on claudins in Sertoli cells using a mouse adult Sertoli cell line as a model. We focus on the Sertoli cell biology looking for the possible implications for male reproductive functions.
Materials and methods: Adult Sertoli cells were transfected with NAPL3 siRNA and treated with NOD1 (ie-DAP) and NOD2 (MDP) receptor ligands. Two dimensional gel electrophoresis was performed on lysates of non-challenged and MDP-treated Sertoli cells.
Results: There were positive claudin-5 and claudin-11 expression levels on transcript (RT-qPCR) levels. Specific protein spots in 2D gels were detected after bioinformatics analysis. This study demonstrates direct induction of tight-junction proteins probably favouring junction stability.
Conclusions: The innate immunity and tight-junction pathway integration probably have a protective role for both blood-testis immune barrier and spermatogenesis compartmentalisation maintained by the very same barrier. This integration also points the way for mechanistic research of the disturbances inflicted during an inflammatory response in the testis niche.
Ulcerated Hemangioma - Surveillance Only
Authors: Chiriac Anca , Chiriac Anca Eduard , Pinteala Tudor , Foia Liliana , Brzezinski Piotr 
Published: October 2015

Abstract
Infantile hemangiomas are reported in 10-12% of children less than 1 year of age, with ulceration in about 5-13% of cases. Little is known about the mechanism of this disease and explanations are still being looked for.
We present a 4-month-old female infant with haemangioma on the left buttock; the hemangioma was noticed at 2 weeks of age, progressively enlarging and ulcerated.
Application of Ionic Liquids in the Utilization of the Agricultural Wastes: Towards the One-Step Pre-Treatment and Cellulose Hydrolysis
Authors: Megyeri Gábor , Nemestóthy Nándor , Polakovic Milan , Bélafi-Bakó Katalin 
Published: October 2015

Abstract
Cheap, renewable lignocellulosic materials are relevant to the future of biofuel production. Wood and agricultural wastes (e.g. straw, corn stover) provide a raw material source that cannot be used for human consumption, thus biofuels from such sources do not threaten the food supply. The aim of the work was to carry out the pre-treatment and hydrolysis of lignocellulosic material in the same ionic liquid solvent (1-n-butyl-3- methyl-imidazolium-chloride, [Bmim]Cl), using ground wheat straw and a mixture of corn (Zea mays) leaf and stover, as substrates. Our measurements show that it is possible to achieve an acceptable glucose content from the cellulose by applying Cellic® CTec2 and Cellic® HTec2 enzyme complexes.
Suberoylanilide hydroxamic acid (SAHA) promotes the epithelial mesenchymal transition of triple negative breast cancer cells via HDAC8/FOXA1 signals
Authors: Wu Shao , Luo Zhi , Yu Peng-Jiu , Xie Hui , He Yu-Wen 
Published: October 2015

Abstract
Inhibitor of histone deacetylases (HDACIs) have great therapeutic value for triple negative breast cancer (TNBC) patients. Interestingly, our present study reveals that suberoyl anilide hydroxamic acid (SAHA), one of the most advanced pan-HDAC inhibitor, can obviously promote in vitro motility of MDA-MB-231 and BT-549 cells via induction of epithelial-mesenchymal transition (EMT). SAHA treatment significantly down-regulates the expression of epithelial markers E-cadherin (E-Cad) while up-regulates the mesenchymal markers N-cadherin (N-Cad), vimentin (Vim) and fibronectin (FN). However, SAHA has no effect on the expression and nuclear translocation of EMT related transcription factors including Snail, Slug, Twist and ZEB. While SAHA treatment down-regulates the protein and mRNA expression of FOXA1 and then decreases its nuclear translocation. Over-expression of FOXA1 markedly attenuates SAHA induced EMT of TNBC cells. Further, silence of HDAC8, while not HDAC6, alleviates the down-regulation of FOXA1 and up-regulation of N-Cad and Vim in MDA-MB-231 cells treated with SAHA. Collectively, our present study reveals that SAHA can promote EMT of TNBC cells via HDAC8/FOXA1 signals, which suggests that more attention should be paid when SAHA is used as anti-cancer agent for cancer treatment.
Demonstrative verbs: A typology of verbal manner deixis
Authors: Guérin Valérie 
Published: October 2015

Abstract
This article presents a typological characterization of a class of demonstratives so far neglected in the literature: demonstrative verbs expressing manner. First, the morphological characteristics and syntactic behaviors of these demonstratives are examined to illustrate their verbal properties and to justify categorizing them as verbs. Next, their exophoric and endophoric roles in narratives and interactions are described. As their discourse usages closely replicate that of nominal demonstratives, we argue that demonstrative verbs belong to the class of demonstratives and propose to integrate them in a general typology of demonstratives.
Genetic aspects of intervertebral disc degeneration
Authors: Hanaei Sara , Abdollahzade Sina , Khoshnevisan Alireza , Kepler Christopher K. , Rezaei Nima 
Published: October 2015

Abstract
Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could play a significant role in the etiology of this disease. Besides, the interactions with environmental factors could make the role of genetic factors more complicated. Genetic variations in disc components could participate in developing degenerative disc disease through altering the normal homeostasis of discs. Gene polymorphisms in disc proteins (collagens I, II, III, IX, and XI), proteoglycans (aggrecan), cytokines (interleukins I, VI, and X), enzymes (matrix metalloproteinases II, III, and IX), and vitamin D receptor seem to play considerable roles in the pathology of this disease. There are also many other investigated genes that could somehow take part in the process. However, it seems that more studies are needed to clarify the exact role of genetics in IVDD.
The Occurrence of Diseases and Related Factors in a Center for Asylum Seekers in Italy
Authors: Firenze Alberto , Aleo Nicola , Ferrara Clara , Maranto Marianna , La Cascia Caterina , Restivo Vincenzo 
Published: October 2015

Abstract

Introduction
Italy is the main recipient of asylum seekers in the European region, and Sicily is their first point of arrival. This geographical position creates a large job for Health Authorities to identify and deal with the health of immigrants. This study evaluates the prevalence of disease among asylum seekers, assessing which are associated factors.

Methods
A cross-sectional study was conducted to analyse demographic and clinical data in an Acceptance Centres for Asylum Seekers from February 2012 to May 2013. All variables that were found to be significant on unvariable analysis for the most frequent pathologies were included in a multivariable logistic regression model.

Results
Post-traumatic stress disorders with 17.4% and major depression with 7.3% were the most frequent diseases. The factors associated with post-traumatic stress disorders among asylum seekers were: major depression diagnosis (OR=2.91, p=0.004), Pakistan as a country of origin (OR=3.88, p <0.001), the largest number of medical visits (OR=1.02, p=0.033) and refugee status (OR=1.97, p=0.036). The variables linked with the diagnosis of major depression from the multivariable analysis were: suffering from post-traumatic stress disorders (OR=3.83, p <0.001), Pakistan as a country of origin (OR=3.45, p=0.004) and the highest number of visits to psychologist (OR=1.15, p <0.001).

Conclusions
The mental wellbeing of asylum seekers needs special attention, and interventions should be done to prevent the consolidation of psychiatric morbidity. A short psychological screening after the arrival might prove helpful here. Moreover, carefully designed longitudinal studies should be carried out when political recommendations try to change the organization of psychological and healthcare services.
The Role of the Psychosocial Dimension in the Improvement of Quality of Care: A Systematic Review
Authors: Makivić Irena , Kersnik † Janko , Klemenc-Ketiš Zalika 
Published: October 2015

AbstractThe aim of our systematic review was to analyse the published literature on the psychosocial dimension of care in family medicine and its relationship with quality of care. We wanted to find out whether there is any evidence on the psychosocial approach in (family) medicine. The recommended bio-psycho-social approach, besides the biomedical model of illness, takes into account several co-influencing psychological, sociological and existential factors. An online search of nine different databases used Boolean operators and the following selection criteria: the paper contained information on the holistic approach, quality indicators, family medicine, patient-centred care and/or the bio-psycho-social model of treatment. We retrieved 743 papers, of which 36 fulfilled our inclusion criteria. Including the psychosocial dimension in patient management has been found to be useful in the prevention and treatment of physical and psychiatric illness, resulting in improved social functioning and patient satisfaction, reduced health care disparities, and reduced annual medical care charges. The themes of patient-centred, behavioural or psychosocial medicine were quite well presented in several papers. We could not find any conclusive evidence of the impact of a holistic biopsycho-social-approach. Weak and variable definitions of psychosocial dimensions, a low number of welldesigned intervention studies, and low numbers of included patients limited our conclusions.
Prevention and therapy of 1,2-dimethyl hydrazine induced colon carcinogenesis by Ferula assafoetida hydroalcoholic extract / 1,2-dimetilhidrazin ile indüklenmiş kalın bağırsak kanserlerinin Ferula assa-foetida ekstraktı kullanılarak önlenmesi ve tedavisi
Authors: Torabi Fatemeh , Dadkhah Abolfazl , Fatemi Faezeh , Dini Salome , Taghizadeh Mohsen , Malayeri Mohammad Reza Mohammadi 
Published: October 2015

Abstract
Objective: In this study, we have evaluated the chemopreventive and chemotherapeutic effects of Ferula assa-foetida hydroalcoholic extract in 1, 2-dimethyl hydrazine (DMH) induced colon carcinogenesis.
Methods: Male Wistar rats were divided into 6 groups: a negative control group without DMH; control group with injected DMH (20 mg/Kg b.w) and four groups receiving DMH +F. assa- foetida extract (6.25 and 12.5 mg/Kg b.w) as chemopreventive and chemotherapeutic groups. The effects of the extracts were assessed by estimating the hepatic oxidative stress/antioxidant parameters such as malondialdehyde, glutathione and ferric reducing ability of plasma (MDA, GSH, FRAP) and the detoxification enzymes; glutathione S-transferase and Cytochrome P450 (GST and CYP450). Moreover, the colonic β-catenin protein was examined in colon tissues followed by the histopathological analysis.
Results: The results showed that the F. assa-foetida extracts markedly reversed the increased levels of CYP450, FRAP and β-catenin and also modulated the reduction of GST (activities and protein) and GSH levels. Histological observations of liver tissue correlated with the above biochemical findings indicating the decrease in the aberrant crypt foci (ACF) formations in the extract treated groups.
Conclusion: The achieved results suggested the beneficial effect of the extracts on DMH metabolic processes in the colon indicating its chemopreventive and chemotherapeutic effects on colon carcinogenesis induced by DMH.
In the history of Department of Biochemistry of Istanbul Medical Faculty (1933–1957) three German scientists; Werner Lipschitz, Felix Haurowitz and Zdenko Stary / İstanbul Tıp Fakültesi Biyokimya Bölümü tarihinde (1933–1957) üç Alman bilim adamı; Werner Lipschitz, Felix Haurowitz ve Zdenko Stary
Authors: Aras Şükrü , Armutcu Ferah , Dinç Gülten 
Published: October 2015

Abstract
Escaping from the chaotic environment of Germany before World War II, several scientists, some of whom were biochemists, took refuge in Turkey and made huge contributions in the preparations of new university reforms beginning in 1933. During this period, three wellknown biochemistry scholars, Werner Lipschitz, Felix Haurowitz and Zdenko Stary were accepted into the Biochemistry Institute of Istanbul University, and each one of these scientists became the head of this institute respectively. Being at the zenith of their careers, these three scientists spent their most prolific years in the Biochemistry Institute. The first biochemist taking charge of the reforms, Werner Lipschitz, established a fully equipped laboratory during his term in his own right and with the support of some officials. During his stint, he published several articles and a biochemistry book. However, Lipschitz had to challenge some difficulties such as learning Turkish and finding qualified Turkish assistants. Felix Haurowitz and Zdenko Stary, on the other hand, learnt Turkish in a short time and gave their lectures in Turkish. Conducting many studies, encouraging their Turkish assistants to involve in most of these studies and training them attentively, these academicians emphasized the importance of the graduate ‘PhD’ education and tried to give education to all of their assistants. They gave lectures in several fields, designed courses and attracted attention to the science of biochemistry. Besides, they published biochemistry books in Turkish. Thus, they made contributions to the development of scientific mentality in the field of biochemistry in Turkey.
Distribution of genetic polymorphism of CAT C-262T in three Iranian populations / Üç İran popülasyonunda CAT C-262T genetik polimorfizminin dağılımı
Authors: Saadat Mostafa , Mousavi-Kazerooni Fatemeh , Fallahzadeh-Abarghooei Leila 
Published: October 2015

Abstract
Objective: Catalase (CAT) activity is likely to be affected by functional polymorphism of C-262T (rs1001179) in the CAT gene (OMIM: 115500). It is hypothesized that individuals with the lower expressing forms of the CAT polymorphism may be more susceptible to breast cancer. In order to find the allelic frequency of the C-262T polymorphism among Iranian populations, the present study was carried out.
Methods: The total study subjects consisted of 1057, 200, and 200 individuals from Shiraz (Fars province; belong to Persians), Abarku (Yazd province; belong to Persians), and Yasuj (Kohgiluyeh va Boyer-Ahmad province; belong to Lurs), respectively. Genotypic analysis for the CAT C-262T polymorphism was determined by PCR.
Results: The frequency of the T allele was 0.2044±0.0138, 0.1825±0.0193, and 0.1800±0.0192 in Shiraz, Abarku, and Yasuj, respectively. The genotypic frequencies of the control subjects did not show significant deviation from Hardy-Weinberg equilibrium. Statistical analysis indicated that there was no significant difference between these populations for the genotypic distributions of the CAT C-262T polymorphism (χ2=2.73, df=4, P=0.603).
Conclusion: The frequency of the T allele among Iranian populations was very similar to that reported for Caucasians and was higher than Asians and African-American populations.
Comparison of classical and clustering based reference interval calculations for Aspartate Aminotransferase, Alanine Aminotransferase and Gamma-Glutamyl Transferase in serum / Aspartat Aminotransferaz, Alanin Aminotransferaz ve Gama Glutamil Transferaz serum için klasik ve kümelemeye dayalı referans aralık hesaplamalarının karşılaştırılması
Authors: Coşgun Erdal , Topçu Deniz İlhan , Laleli Yahya 
Published: October 2015

AbstractObjective: There are fixed rules applied to determine the reference intervals (RIs) of the biochemical tests. However, these rules lack for identifying subgroups within the reference population. Therefore, we suggest the clustering method, which determines the sub-groups by taking the correlations between the variables into account in the RIs calculations. In our study, it is aimed to compare the results of the RIs based on the clusters analysis with the results of the conventional method.Methods: The individuals who applied Ankara Düzen Laboratory for the check-up with normal Ultra Sono Grafi (USG) in 2012-2014 and who have had Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and G-Glutamyl Transferase (GGT); (U/L) results were included in this study. We have excluded the repeated applies of patients, only analyzed the first apply to the laboratory. Reference individuals are composed of 883 people. (610 male, 273 female, 18-70 years). Non-parametric methods were used to determine reference intervals. Fuzzy C-Means clustering method was used to identify sub-groups.Results: AST, ALT, GGT measurements for all of the check-up individuals were determined by non-parametric method for the three subgroups specified after the Fuzzy- C-Means clustering method and the entire group. According to the reference intervals obtained, the third sub-cluster derived from the group intended to be used as the reference population was observed as a cluster that is narrower, and has similar properties of the actual reference population. However, when the correlations between the tests in the sub-groups are considered, the correlations between GGT-ALT-AST have been observed to be higher while the correlation level between ALT-AST in the group proposed as a real reference population does not change.Conclusion: In the reference limit studies, instead of the determination of the reference interval for a single group designated as the reference population, we think that, the subgroups which are homogeneous within itself, heterogeneous between themselves should be set in in this group. In determining multiple sub-groups, the relationship between more than one test need to be taken into consideration, and the effect of clustering should be investigated.