bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficacy of Intralesional Pentoxifylline Injection versus the Standard Intralesional Corticosteroid Injection in The Treatment of Alopecia Areata
Authors: Abdel fattah Nermeen Samy , Abdallah Tarek Nabil , Ibrahim Samah , Hamdy Mohammed Samar Elaraby 
Published: July 2024

Abstract

Background
Alopecia areata is a nonscarring skin disease affecting the scalp or other body parts. The etiology of AA is still controversial and various pathogenic causes are under investigation. Several treatment modalities are used in managing AA.

Objective
to evaluate the efficacy and safety of (PTX) injection in treatment of localized AA compared to intralesional corticosteroids TRA on 30 patients with multiple patches of AA.

Patients and Methods
The current study was a prospective intra-patient comparative controlled clinical trial. Patients were recruited form outpatient clinic of Dermatology, Ain Shams University Hospital in the period from November 2019 to May 2020. 30 Egyptian patients (11 males &19 females) with at least three patches were enrolled to the study. The diagnosis of AA patients enrolled in the study based on clinical signs.

Results
To sum up, both PTX and ILCS has good results in treatment of AA, as each of them has its own advantages. Corticosteroids are rapidly acting while PTX effects are delayed but increased progressively throughout consecutive sessions. So using corticosteroids in combination with PTX can augment each other and give better results.

Conclusion
Treatment of AA with intralesional PTX exerted significant increase in hair density, total hair count, terminal hair count and percentage of terminal hair which is evident after completion of the sessions. Treatment with ILCS exerted significant increase hair density, total hair count, terminal hair count and percentage of terminal hair after treatment. Comparison of both treatment modalities revealed slight better response with PTX compared to ILCS. In conclusion, the current study revealed that Intralesional combined administration of PTX and TRA can be beneficial for patients suffering from AA. Steroid showed a rapid response that could be maintained by adding PTX.
Prevalence of Sexual Dysfunction among Psoriatic Male Patients
Authors: Ibrahim Shaheen Sarah Shaheen , Lofty Rania Adel , Elfattah Afify Ahmed Abd 
Published: July 2024

Abstract

Background
psoriasis is a recurring, cutaneous-articular, chronic inflammatory disease, resulting from immune and proliferative changes that affect the skin and mucosa. The worldwide incidence is 1-3% and the majority of the patients also have emotional difficulties like anxiety, depression, and sexual dysfunction. These issues along with the extent of body surface area affected have an impact on the quality of life, in particular, the sexual life, all aspects of sexual function were negatively affected by the disease process.

Aim of the Work
to evaluate the prevalence of sexual dysfunction among psoriatic male patients and the role of depression on sexual dysfunction.

Patients and Methods
the study included 60 male psoriatic patients (married sexually active with no genital abnormalities, malignancy, chronic diseases such as pulmonary, hepatic, renal, hematological, neurologic, psychosis, and similar psychiatric disorders, and not on medications that interfere with erectile function). All patients were subjected to the following: Full medical history taking, local examination of the genitalia, dermatological examination, sexual function evaluation using the Arabic version of IIEF (the international index of erectile function questionnaire) which is a validated questionnaire applied to all cases, and psychiatric evaluation using the Arabic version of Hence Hamilton Depression rating scale (HAM-D) to determine the patient’s level of depression.

Results
The study revealed a high prevalence of ED (86.7%) and depression (65%) among psoriatic male patients, the ED was statistically significantly affected by the severity, duration of the disease, and genital affection. Also, there was a significant correlation between ED, metabolic parameters, and depression with a significant P value.

Conclusion
there is a high prevalence of sexual dysfunction and depression among psoriatic male patients. Screening of sexual dysfunction among psoriatic male patients using the IIEF, depression using HAM-D, and metabolic risk factors is recommended for a better quality of life.
Comparative Clinical Trial of Dermapen Microneedling and Platelet-Rich Plasma versus Dermapen Microneedling Alone in the Treatment of Stretch Marks in Egyptian Adults
Authors: Anis Basily Amir Adel , Halim Imam Adel Ahmed , Ahmed Saleh Hanan Mohamed 
Published: July 2024

Abstract

Background
Striae distensae are common skin lesions affecting up to 90% of pregnant women, and many adolescents and men. They pose a psychological burden to many people and no known treatment is completely effective for them. The current treatment options are limited by significant side effects, operator skill, cost, prolonged treatment period, or a combination thereof. Platelet-rich plasma (PRP), along with microneedling (MN), are promising dermatologic procedures with a wide range of applications, excellent safety profiles, yet only partially understood mechanisms of action.

Aim of the Work
to evaluate the effectiveness and side effects of MN with PRP versus MN alone in the treatment of striae distensae. This work included 40 patients who were divided into left-side lesions (MN alone) versus right-side lesions (PRP + MN). PRP was prepared using single-spin technique, and applied topically just before MN on right-side lesions. An automated MN pen device was used on both sides.

Patients and Methods
This was a prospective case control study with a split-body design which included 40 adult patients with striae distensae. The patients were recruited from the outpatient dermatology clinic in Ain Shams University hospitals, Cairo. Miravex Antera TM 3D Camera system measured the efficacy by indentation and roughness indices, and patients’ subjective improvement and reported side effects were recorded and analysed.

Results
A significant improvement was illustrated in both MN and MN + PRP sides in both the indentation and roughness indices measured by the Antera 3D camera system, and most patients reported subjective improvement in color (62.5%), smoothness (97.5%), size (82.5% vs 85%), and general appearance (92.5% vs 90%). Side effects including pain and erythema affected virtually all cases, while pruritis, edema, bleeding, and tram-tracking were less common and short-lasting. Post-inflammatory hyperpigmentation affected about 20% of patients and lasted more than one month in about half of those affected. No significant difference was found between MN and MN + PRP in efficacy or side effects.

Conclusion
Microneedling offers an effective, cheap, and relatively safe treatment option for striae distensae. Miravex Antera TM 3D Camera system is a powerful objective method of documenting lesions and following up the treatment process. Platelet-rich plasma did not offer additional benefit over microneedling alone.
Linear Measurement of Females' Vocal Fold Across Different Ages
Authors: El Kholy Basma Ahmed , Aziz Rifaie Nahla Abdel , Quriba Amal Saeed , Elfiky Yomna Hassan 
Published: July 2024

Abstract

Background
One of the most complex oragns of the human body is the larynx so Understanding its morphology is an important step toward understanding the detailed laryngeal anatomy, and physiology. Different studies have described the linear measurements of the larynx in different measuring methods. but no studies have been structured to describe vocal fold length in vivo in females at different stages of their lives.The vocal instrument is comprised of the vibratory body, the respiratory power source and the oropharyngeal resonating chambers. Voice is characterized by its intensity, frequency, and harmonics. The harmonics are hormonally dependent.

Aim of the Work
The aim of this study is to screen the membranous vocal fold length in different ages throughout females’ life and if it is affected by hormonal changes in their lives or not.

Study Design
a comparative cross-sectional study.

Patients and Methods
This comparative cross-sectional study was carried out on 120 Egyptian Arabic speaking apparently healthy females at the outpatient clinic of the Units of Phoniatrics, ENT Department of both Ain Shams University Hospitals and Zagazig University Hospitals.

Results
It was obvious that female’s larynx is affected by age and sex hormones that is reflected on the laryngeal structure and function. Although the results showed non significant relation between the length of the membranous part to aging this may be due to small sample size that could not reflect that difference.

Conclusion
The vocal imprint is characteristic to each individual. It reveals personality and translates emotions. The voice evolves with age. It bears both the scars of life, as well as its joys and pleasures. Nevertheless, the human voice remains intangible and a fertile field for future research in the cycle of life.
Efficacy of Barbed Reposition Pharyngoplasty and Uvulopalatopharyngoplasty for Retro Palatal Obstruction
Authors: Hassan Mohamed Amir , Mostafa Mostafa Mohamed , Beder Mohamed Ashraf , Kamel Ahmed Mohamed 
Published: July 2024

Abstract

Background
Obstructive sleep apnoea (OSA) is a common problem affecting almost 4% of the population. Although continuous positive airway pressure (CPAP) is considered the standard of care, the patient compliance for long term use is poor. Clinicians have explored surgical options for cure with varying success.

Objective
To analyze the efficacy of a new modified pharyngoplasty technique (BRP) in comparison with other UPPP techniques to displace the soft palate anteriorly and lateralize the lateral pharyngeal wall in the treatment of OSA.

Patients and Methods
Types of studies: Systematic review/Meta-analysis. Types of participants: Patients Complain of OSA caused by mild to moderate retropalatal obstruction. Study outcome: efficacy of barbed suture and UPPP operations for retropalatal obstruction, study of success rate. Study of failure rate. Study of complications.

Results
Regarding Change in ODI Associated with Barbed Sutures, it was found that only 2 studies assessed ODI, and this analysis showed that Weighted mean difference = -23.32 (95% CI = -35.08 to -11.56). There is substantial heterogeneity across studies (Cochran Q test P-value = 0.099, I-squared = 63.33%). In the UPPP procedure, only two studies assessed the ODI, this analysis showed that the weighted mean difference = -14.27 (95% CI = -20.62 to -7.92). There is substantial heterogeneity across studies.

Data Sources
Medline databases (PubMed, Medscape, ScienceDirect. EMF-Portal) and all materials available in the Internet till 2021.

Conclusion
Both Barbed reposition pharyngoplasty and Uvulopalatopharyngoplasty techniques were effective in the treatment of cases with obstructive sleep apnoea (OSA). Barbed reposition pharyngoplasty (BRP) can be considered as the gold standard procedure. BRP seem to be more effective than UPPP in a single-level surgical setting. However, being quick, easy to learn and less invasive, BRP is a safe, effective and promising option for treatment of patients with OSA.
Role of Adjuvant Mitomycin C in The Endoscopic Treatment of Laryngotracheal Stenosis (Meta-Analytic Study)
Authors: Eldin Elhalabi Hisham Salah , El Aty Elsersy Hesham Abd , Mohamed Amr Hamed , Hassan Ahmed Mohamed Shokry 
Published: July 2024

Abstract

Background
Laryngotracheal stenosis is a life-threatening restriction in pulmonary ventilation. It is an umbrella term, including luminal compromise at the level of the larynx, subglottis, or trachea. Etiology of laryngotracheal stenosis is multifactorial. In adults and adolescents it is mostly acquired, where in children it may be acquired or congenital. Acquired laryngotracheal stenosis can result from previous intubation or tracheostomy, systemic disease, trauma, infection, or idiopathic causes. Historically, infectious etiology was common. Currently, laryngotracheal stenosis most frequently results from prolonged intubation or trauma from intubation itself.

Objective
To evaluate the effectiveness of topical Mitomycin C as an adjuvant treatment with the endoscopic management of laryngotreacheal stenosis.

Patients and Methods
The total number of patients in all the included studies was 454, 379 patients in MMC group and 75 patients in non-MMC group.

Results
This meta-analysis study showed that resolution (success) rate in MMC group was (68.7%) and there was a significant increase in resolution (success) rate in MMC compared to non- MMC group (p = 0.011) with the odds of being 5 times higher in MMC group (OR = 5.04). The Complications rate in MMC using patients was (4%). The result of this meta-analysis study showed that Mitomycin C is an effective and safe adjuvant in the endoscopic treatment of laryngotracheal stenosis. However, this study included limitations. We recommend the need of more high quality prospective randomized controlled trials, two armed studies and further studies in the future to achieve stronger results.

Conclusion
We suggest that that Mitomycin C is an effective and safe adjuvant in the endoscopic treatment of laryngotracheal stenosis. However, this study included limitations. We recommend the need of more high quality prospective randomized controlled trials, two armed studies and further studies in the future to achieve stronger results.
Barbed Expansion Sphincter Pharyngoplasty (BESP) for the Treatment of OSA. “A Step Ahead”
Authors: El Salamawy Ahmed , El Fatah Gamal Abd , Fathi Hesham , Farahat Ahmed , Youssef Mysara 
Published: July 2024

Abstract

Background
expansion sphincter pharyngoplasty is one of the newly introduced techniques for treating OSA in the last 20 years that showed promising results by increasing the lateral dimensions of the oropharynx by pulling the lateral pharyngeal wall and anchoring it to the pterygomandibular raphe, the paper study the efficacy of performing the procedure using the barbed suture on moderate to severe OSA.

Methods
Twelve patients with moderate to severe OSA due to oropharyngeal collapse according to VOTE classification after DISE were assigned to the study. Pre- and post-operative Epworth sleepiness scale questionnaire was completed, Pre- and post-operative polysomnography was performed as an objective measurement, all patients underwent BESP and the duration, post- operative complications, and pain records were plotted.

Results
The technique was confirmed to be feasible with a success rate of 91.7%, with reduction of median AHI from (38.75 to 8.7 event/hour) and reduction of the mean ESS from (20.83 to 5.67) and mean ODI (37.62 to 9.38).

Conclusion
The barbed expansion sphincter pharyngoplasty is an effective technique for treating obstructive sleep apnea in patients with retropalatal and oropharyngeal collapse.
Quality of Life in Pediatric Iritable Bowel Syndrome among a Sample of Egyptian Children at Ain Shams University Hospitals
Authors: El Ezaby Sarah Abdel Rahman A , Anzour Ayat Farouk M , El Gendy Yasmin Gamal A , El Deeb Marwa Talaat , Abdel Hamed Diaa Marzouk 
Published: July 2024

Abstract

Background
Iritable bowel syndrome (IBS) is one of the pediatric functional gastrointestinal disorder with upper and lower gastrointestinal symptoms.IBS afects the child’s daily activities and quality of life (QoL) negatively, and can often persist into adulthood.

Objectives
To measure the dimensions of QoL of children with IBS among a sample of Egyptian pediatric patients at Ain Shams University Hospitals.

Methods
A cross-sectional study was conducted on 80 children aged 5-15 years old, who were diagnosed as IBS, according to Rome IV criteria Pediatric quality of life Inventory Generic Core (PedsQL generic core scale was used to measure QoL of the patients,where 100 is the maximum quality score.

Results
A total of 80 children participated in the study ; 48 (60%) males and 32 (40%) females with mean age 10.6 (SD2.7) years. Physical functioningscorewascalculatedtobe96.04(SD5.5), socialfunctioning score was 99.37 (SD3.95), emotional functioning score was 90.37 (SD8.85), and school functioning score was 73.25 (SD27.34).The school functioning scale was higher among male participants (P-value0.31), also the emotional scale was higher among male participants with no statistical significant diference (P-value0.70).

Conclusion
IBS afects the school functioning dimension of OoL among the pediatric age group rather than other dimensions.
Influence of Female Genital Mutilation on Women Sexual Function in Egypt
Authors: Abo Ghanima W A , Ragab M H , Hegab M H , Abd El Gawad A M , Elhelaly H M 
Published: July 2024

Abstract

Background
Although Female genital mutilation (FGM) is internationally recognized as a violation of human rights with Short term and long term complications include death due to shock, painful menstruation, dyspareunia, cysts and keloid formation.

Aim of the Work
aimed to assess the effect of FGM on Women reproductive and sexual function.

Subjects and Method
This is a cross sectional hospital based study included 800 married or previously married females, between (18 - 40) year old who are apparently healthy. They were recruited from Outpatient clinic of Gynecology and Obstetrics in Etay Elbaroud general hospital, Behaira Governate, Egypt and classified into case group who were circumcised and control non circumcised group. They were subjected to detailed history including history of sexual function and local genital examination after informed consent was taken. During labor; a partogram was used to assess the progess of labor and occurrence of complicated delivery. Partogram is a graph reporting labor events against time which includes cervical dilatation, fetal heart rate, state of membrane and liquor.

Results
among case group age of FGM ranged from 9-13 with mean value 10.27±0.98 and majority of cases had type I. There was statistically significant difference between the two studied groups regarding regularity of menses and dysmenorrhea. 66% of cases had short term complication and pain was the most common (52%). Assisted mode delivery was higher in cases group with 220(55%) and normal was higher in control group with 244(61%). There was statistical significant difference between two studied groups regarding sexual desire, arousal, orgasm, satisfaction, and pain while there was no statistical significant difference regarding lubrication.

Conclusions and Recommendations
FGM still being a community problem in Egypt esecially in rural area which running in certain families. The most common type in Egypt is type I and common complication is pain following FGM. Sexual function is affected in all cases experienced FGM especially with type III. Assisted delivery was more common in cases had passed FGM before. It is recommended to raise community awareness about complications and hazard of FGM on sexual function as well as reproductive life.
Surgical and Morphological Outcome of One Stage Laparoscopic Orchidopexy with Preservation of Gubernaculum and Interruption of Spermatic Vessels in Comparison to Two Stages Fowler–Stephens’s Orchidopexy Technique with Preservation of Gubernaculum for Impalpable Testis
Authors: El Kashory Ahmed Ibramim Abd El Hamid , Abdelhamid Sameh Abdelhay , El Asmar Khaled Mohamed , El Sherbeny Mohamed Saeed , Dahab Mohamed Mousa 
Published: July 2024

Abstract

Introduction
Laparoscopy has attained full acceptance, both diagnostically and therapeutically for the management of non-palpable testis. Conventional laparoscopic Fowler-Stephens’s orchidopexy is a common accepted technique for cases where spermatic vessels` length can preclude tension-free testicular mobilization in the scrotum. Gubernaculum sparing with cutting of testicular vessels has an important role to keep a good vascularity of the testis. Our study suggests performing F-S technique with preservation of the gubernaculums in one stage instead of two stages with the same final results.

Patients and Methods
This was a Randomized controlled clinical trial (RCT), conducted on Boys with Non-palpable testicle between 1 year to 6 years old, in 2 Egyptian pediatric surgery units, between October 2019 and September 2022.The patients met our inclusion criteria were divided into 2 groups to compare their outcome (atrophy and success rate): ( Group A with 25 impalpable testicle were subjected to one-stage laparoscopic assisted orchidopexy with interruption of spermatic vessels and preservation of the gubernaculums, while Group B with 25 impalpable testicle were subjected to two-stages laparoscopic assisted orchidopexy with interruption of spermatic vessels and preservation of the gubernaculums).

Results
The mean age of all patients were (3.9 ± 1.8), 113 non-palpable testicle were examined during the period of our study, 50 non-palpable tesicle were met our inclusion criteria. They were divided into 2 groups according to surgical procedure. There were no significant differences between the 2 groups according to age, preoperative testicular volume. Post operative outcome (atrophy and success rate) had no significant differences. Operative time and hospital stay were statistically decreased in the group performed with one stage.

Conclusion
One-stage laparoscopic orchidopexy with preservation of gubernaculum and ligation of testicular vessels to be as effective as two-stage laparoscopic Fowler–Stephens’s orchidopexy with preservation of gubernaculum.