bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Methyl Ketone Oxime Esters as Nucleophilic Coupling Partners in Pd‐Catalyzed C—H Alkylation and Application in the Synthesis of Isoquinolines.
Authors: Zhang Zhi‐Wei , Lin Aijun , Yang Jiong 
Published: January 2015

AbstractThe process is regioselective and can be used for the preparation of various isoquinolines with different substitution pattern.
ChemInform Abstract: Study on One‐Pot Four‐Component Synthesis of 9‐Aryl‐hexahydro‐acridine‐1,8‐diones Using SiO2—I as a New Heterogeneous Catalyst and Their Anticancer Activity.
Authors: Ramesh K. B. , Pasha M. A. 
Published: January 2015

AbstractNew compounds (IIIc), (IIId), (IIIg), (IIIh) exhibit very good anti‐cancer activities towards hepatocellular carcinoma cells (HepG2) and compounds (IIIb), (IIId), (IIIg) and (IIIh) show good activities towards human breast cancer adenocarcinoma cells (MCF).
ChemInform Abstract: Enantioselective Construction of 2,3‐Dihydrofuro[2,3‐b]quinolines Through Supramolecular Hydrogen Bonding Interactions.
Authors: Zhong Fangrui , Bach Thorsten 
Published: January 2015

AbstractIn general, furo[2,3‐b]quinolines represent an important class of alkaloids which show different pharmacological and biological properties.
ChemInform Abstract: Three‐Component Cascade Reaction Synthesis of Polycyclic 1,4‐Dihydropyridine Derivatives in Water.
Authors: Ma Yu‐Lu , Wang Kai‐Min , Lin Xin‐Rong , Yan Sheng‐Jiao , Lin Jun 
Published: January 2015

AbstractAn efficient and environmentally friendly approach for an easy access to a wide range of new title compounds (IV) is developed without any need of organic solvent.
ChemInform Abstract: Convenient Synthesis of 1a,1b,2,5‐Tetrahydro‐1H‐5a‐aza‐cyclopropa[a]indenes by Base Promoted Cyclodimerization of 1,1‐Dicyano‐2‐aryl‐3‐benzoylcyclopropanes.
Authors: Han Ying , Tang Wan‐Quan , Guo Ling‐Yu , Yan Chao‐Guo 
Published: January 2015

AbstractUnprecedented cyclomerization of the title benzoylcyclopropanes (IV) gives the novel azacyclopropaindene derivatives (III) in moderate yields.
ChemInform Abstract: A New, Simple, and High‐Yielding Synthesis of 2,9‐Dihydro‐1H‐pyrido[3,4‐b]indol‐1‐ones.
Authors: La Regina Giuseppe , Famiglini Valeria , Passacantilli Sara , Pelliccia Sveva , Punzi Pasqualina , Silvestri Romano 
Published: January 2015

AbstractA simple protocol allows the synthesis of the title compounds (II) via intramolecular cyclization of substrates (I) in polyphosphoric acid.
ChemInform Abstract: Unexplored Reactivity of 2‐Oxoaldehydes Towards Pictet—Spengler Conditions: Concise Approach to β‐Carboline Based Marine Natural Products.
Authors: Battini Narsaiah , Padala Anil K. , Mupparapu Nagaraju , Vishwakarma Ram A. , Ahmed Qazi Naveed 
Published: January 2015

AbstractNumerous glyoxals are prepared in situ from acetone (IIj), acetophenone derivatives (IIa‐i) as well as other variously substituted acetophenone derivatives and subsequently transformed with tryptophane (I) to carbolines.
ChemInform Abstract: Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles Using Cyanuric Chloride in Water.
Authors: Pandey Anand Kumar , Sharma Rashmi , Singh Awantika , Shukla Sanjeev , Srivastava Kumkum , Puri Sunil K. , Kumar Brijesh , Chauhan Prem M. S. 
Published: January 2015

AbstractThe antimalarial and cytotoxic activity of the products is evaluated.
ChemInform Abstract: Regioselective Synthesis of Fused Imidazo[1,2‐a]pyrimidines via Intramolecular C—N Bond Formation/6‐Endo‐Dig Cycloisomerization.
Authors: Kumar Atul , Kumar Mukesh , Maurya Shivam , Khanna Ranjana S. 
Published: January 2015

AbstractThe 3‐component reaction is efficiently catalyzed by the transition metal system.
ChemInform Abstract: Oxidant‐ and Metal‐Free Synthesis of 4(3H)‐Quinazolinones from 2‐Amino‐N‐methoxybenzamides and Aldehydes via Acid‐Promoted Cyclocondensation and Elimination.
Authors: Cheng Ran , Tang Linlin , Guo Tianjian , Zhang‐Negrerie Daisy , Du Yunfei , Zhao Kang 
Published: January 2015

AbstractNitro‐group in either of the substrates leads to the formation of dihydroquinazolinone products which can be further transformed to the desired quinazolinones [cf.
ChemInform Abstract: Five‐Membered Heteroaromatic Ring Fused‐Pyrimidine Derivatives: Design, Synthesis, and Hedgehog Signaling Pathway Inhibition Study.
Authors: Zhang Liandi , Xin Minhang , Shen Han , Wen Jun , Tang Feng , Tu Chongxing , Zhao Xinge , Wei Ping 
Published: January 2015

AbstractAmong the new pyrimidine derivatives, compounds (I) are the most potent hedgehog signaling pathway inhibitors.
ChemInform Abstract: New Fluorinated 1,2‐Diaminoarenes, Quinoxalines, 2,1,3‐Arenothia(selena)diazoles and Related Compounds.
Authors: Makarov Arkady G. , Selikhova Natalia Yu. , Makarov Alexander Yu. , Malkov Victor S. , Bagryanskaya Irina Yu. , Gatilov Yuri V. , Knyazev Alexey S. , Slizhov Yuri G. , Zibarev Andrey V. 
Published: January 2015

AbstractUseful synthetic approaches for the preparation of fluorinated 1,2‐diaminoarenes, quinoxalines, 2,1,3‐arenothia(selena)diazoles and related compounds starting from corresponding fluorinated anilines (I) are elaborated.
ChemInform Abstract: Regioselective Synthesis of Diversely Substituted Diazoninones Through a Post‐Ugi Gold‐Catalyzed Intramolecular Hydroarylation Process.
Authors: Li Zhenghua , Kumar Amit , Vachhani Dipak D. , Sharma Sunil K. , Parmar Virinder S. , Van der Eycken Erik V. 
Published: January 2015

AbstractGold‐catalyzed cyclization of Ugi four‐component reaction products opens efficient access towards fused nine‐membered heterocyclic ring systems.
ChemInform Abstract: Asymmetric Annulation of 3‐Alkynylacrylaldehydes with Styrene‐Type Olefins by Synergetic Relay Catalysis from AgOAc and Chiral Phosphoric Acid.
Authors: Zhang Hao , Zhu Le , Wang Shaozhong , Yao Zhu‐Jun 
Published: January 2015

AbstractThe optimized conditions shown in the scheme are elaborated and tested in the annulation process.
ChemInform Abstract: Ligand‐Controlled Divergent Formation of Alkenyl‐ or Allylboronates Catalyzed by Pd, and Synthetic Applications.
Authors: Martos‐Redruejo Alicia , Lopez‐Duran Ruth , Bunuel Elena , Cardenas Diego J. 
Published: January 2015

AbstractThe selective formation of alkenyl‐ and allylboronates from allyl carbonates is controlled by the employed ligand.
ChemInform Abstract: Iridium‐Catalyzed Regioselective Silylation of Aromatic and Benzylic C—H Bonds Directed by a Secondary Amine.
Authors: Li Qian , Driess Matthias , Hartwig John F. 
Published: January 2015

AbstractThe scope and limitations of the regioselective directed silylation of benzylic amines and subsequent reductive cyclization to azasilolanes (III) and (V) using norbornene as hydrogen acceptor is developed.
ChemInform Abstract: Magnetically Recyclable Nano‐Fe2O3‐Catalyzed Chemoselective Synthesis and Antioxidant Activity of Diethyl (3‐((5‐Aryl‐1H‐1,2,4‐triazol‐3‐yl)thio)propyl)phosphonates.
Authors: Murty M. S. R. , Katiki Mohana Rao , Rao B. Ramalingeswara , Nanubolu Jagadeesh Babu , Buddana Sudheer Kumar , Prakasham R. S. 
Published: January 2015

AbstractThe title compounds (III) are obtained by an efficient, green, and chemoselective S‐alkylation of 1,2,4‐triazole‐3‐thiones (I) with (3‐bromopropyl)phosphonate (II) in water under ligand‐ and base‐free conditions.
ChemInform Abstract: A New Cyclic Triterpene Saponin from Phyteuma japonicum.
Authors: Lee Kang Ro , Kim Chung Sub , Kwon Oh Wook , Kim Sun Yeou , Kim Ki Hyun 
Published: January 2015

AbstractPhyteujaposide (I) is isolated and shown to have moderate effect on LPS‐induced NO production in BV‐2 microglia cells and no influence on cell viability.
ChemInform Abstract: Sesquiterpenoids with PPARδ Agonistic Effect from a Korean Marine Sponge Ircinia sp.
Authors: Hahn Dongyup , Chin Jungwook , Kim Hiyoung , Yang Inho , Won Dong Hwan , Ekins Merrick , Choi Hyukjae , Nam Sang‐Jip , Kang Heonjoong 
Published: January 2015

AbstractCompounds (I) and (IIc) show PPARδ agonistic activities.
ChemInform Abstract: Synthesis and Biological Evaluation of Raddeanin A, a Triterpene Saponin Isolated from Anemone raddeana.
Authors: Qian Shan , Chen Quan Long , Guan Jin Long , Wu Yong , Wang Zhou Yu 
Published: January 2015

AbstractRaddeanin A (I) is synthesized by a stepwise glycosylation strategy.
ChemInform Abstract: Synthesis and Cytotoxicity of a Diazirine‐Based Photopsammaplin.
Authors: Hentschel Fabia , Raimer Bjoern , Kelter Gerhard , Fiebig Heinz‐Herbert , Sasse Florenz , Lindel Thomas 
Published: January 2015

AbstractThe first photoreactive derivative (I) of psammaplin A shows in vitro anticancer activity against various human cancer cell lines.
ChemInform Abstract: High Adsorption Capacity for Cationic Dye Removal and Antibacterial Properties of Sonochemically Synthesized Ag2WO4 Nanorods.
Authors: Dutta Dimple P. , Singh Anamika , Ballal Anand , Tyagi Avesh K. 
Published: January 2015

AbstractThe title nanorods with an average diameter of 15—25 nm and a surface area of about 115 m2/g are synthesized by irradiation of an aqueous solution of Na2WO4 and AgNO3 under air for 1.5 h with high intensity ultrasonic radiation at 40 kHz.
ChemInform Abstract: Organocatalysis in Enantioselective α‐Functionalization of 2‐Cyanoacetates
Authors: Diaz‐de‐Villegas Maria D. , Galvez Jose A. , Badorrey Ramon , Lopez‐Ram‐de‐Viu Pilar 
Published: January 2015

AbstractReview: [61 refs.
ChemInform Abstract: Multi‐Branched Multi‐Anchoring Metal‐Free Dyes for Dye‐Sensitized Solar Cells
Authors: Manfredi Norberto , Cecconi Bianca , Abbotto Alessandro 
Published: January 2015

AbstractReview: [design strategies, main synthetic routes, optical and photovoltaic properties of two families of multi‐branched sensitizers; 47 refs.
ChemInform Abstract: Synthetic Applications of 1,3‐Dipolar Cycloadditons of Azomethine Ylides and Use in Molecular Nanotechnology
Authors: Sharma Kusum , Shrivastava Barkha , Prashant Anita , Joshin Rahul , Pardasani R. T. 
Published: January 2015

AbstractReview: 31 refs.
ChemInform Abstract: Nanocomposites Based on Polytetrafluoroethylene and Ultrahigh Molecular Weight Polyethylene: A Brief Review
Authors: Kirillina Iu. V. , Nikiforov L. A. , Okhlopkova A. A. , Sleptsova S. A. , Yoon Cheonho , Cho Jin‐Ho 
Published: January 2015

AbstractReview: 56 refs.
ChemInform Abstract: Kinetic Analysis of Inactivation and Enzyme Reaction of Oxygen‐Tolerant [NiFe]‐Hydrogenase at Direct Electron‐Transfer Bioanode
Authors: So Keisei , Kitazumi Yuki , Shirai Osamu , Kurita Kouhei , Nishihara Hirofumi , Higuchi Yoshiki , Kano Kenji 
Published: January 2015

AbstractReview: 43 refs.
The role of liquid‐based cytology and ancillary techniques in pleural and pericardic effusions: An institutional experience
Authors: Rossi Esther Diana , Bizzarro Tommaso , Schmitt Fernando , Longatto‐Filho Adhemar 
Published: January 2015

BACKGROUNDFine‐needle aspiration cytology (FNAC) of serous membrane effusions may fulfil a challenging role in the diagnostic analysis of both primary and metastatic disease. From this perspective, liquid‐based cytology (LBC) represents a feasible and reliable method for empowering the performance of ancillary techniques (ie, immunocytochemistry and molecular testing) with high diagnostic accuracy.METHODSIn total, 3171 LBC pleural and pericardic effusions were appraised between January 2000 and December 2013. They were classified as negative for malignancy (NM), suspicious for malignancy (SM), or positive for malignancy (PM).RESULTSThe cytologic diagnoses included 2721 NM effusions (2505 pleural and 216 pericardic), 104 SM effusions (93 pleural and 11 pericardic), and 346 PM effusions (321 pleural and 25 pericardic). The malignant pleural series included 76 unknown malignancies (36 SM and 40 PM effusions), 174 metastatic lesions (85 SM and 89 PM effusions), 14 lymphomas (3 SM and 11 PM effusions), 16 mesotheliomas (5 SM and 11 SM effusions), and 3 myelomas (all SM effusions). The malignant pericardic category included 20 unknown malignancies (5 SM and 15 PM effusions), 15 metastatic lesions (1 SM and 14 PM effusions), and 1 lymphoma (1 PM effusion). There were 411 conclusive immunocytochemical analyses and 47 molecular analyses, and the authors documented 88% sensitivity, 100% specificity, 98% diagnostic accuracy, 98% negative predictive value, and 100% positive predictive value for FNAC.CONCLUSIONSFNAC represents a primary diagnostic tool for effusions and a reliable approach with which to determine the correct follow‐up. Furthermore, LBC is useful for ancillary techniques, such as immunocytochemistry and molecular analysis, with feasible diagnostic and predictive utility. Cancer (Cancer Cytopathol) 2015;123:258–266. © 2015 American Cancer Society.
Difluorinated 6,13‐Bis(triisopropylsilylethynyl)pentacene: Synthesis, Crystallinity, and Charge‐Transport Properties
Authors: Kim Chang‐Hyun , Hlaing Htay , Payne Marcia M. , Parkin Sean R. , Anthony John E. , Kymissis Ioannis 
Published: January 2015

AbstractFluorination has been demonstrated to improve stability and processing in thiophene‐containing small‐molecule semiconductors. Here, the impact of partial fluorination on these parameters in a pentacene derivative is examined. Although the improvement in photostability is not as dramatic, there is a clear improvement in the stability of the chromophore upon fluorination. The improvement in processability is more dramatic; devices formed by spin‐coating with the fluorinated derivative perform substantially better than those formed from the nonfluorinated compound.
Cubic Perovskite ZnTiO3 Nanopowder as a Recyclable Heterogeneous Catalyst for the Synthesis of 1,6‐Naphthyridines in Water
Authors: Ray Suman , Das Paramita , Banerjee Biplab , Bhaumik Asim , Mukhopadhyay Chhanda 
Published: January 2015

AbstractCubic perovskite ZnTiO3 nanopowder has been prepared by means of a sustainable sol–gel method. The nanopowder (12–20 nm) has been thoroughly characterized by N2 sorption analysis, high‐resolution (HR) TEM, X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), SEM, and FTIR analyses. The environmentally benign synthesis of highly substituted 1,6‐naphthyridines catalyzed by ZnTiO3 nanopowder in aqueous media has been demonstrated. It requires two different catalytic functions, that is, an acid one, which is provided by TiIV ions, and a basic one, which is provided by the oxide ion incorporated within the ZnTiO3 metal oxide framework. 1,6‐Naphthyridines are of tremendous biological importance, and this method is simple and environmentally friendly. The greenness of the process was satisfactorily established as water was exploited as the reaction medium and there was very high atom economy.
How a [CoIV${^{\underline{.....}}}$O]2+ Fragment Oxidizes Water: Involvement of a Biradicaloid [CoII–(⋅O⋅)]2+ Species in Forming the OO Bond
Authors: Crandell Douglas W. , Ghosh Soumya , Berlinguette Curtis P. , Baik Mu‐Hyun 
Published: January 2015

AbstractThe mechanism of water oxidation performed by a recently discovered cobalt complex [Co(Py5)(OH2)](ClO4)2 (1; Py5=2,6‐(bis(bis‐2‐pyridyl)‐methoxymethane)pyridine) was examined using quantum chemical models based on density functional theory. The computer models were first benchmarked against the experimental cyclic voltammetry data to identify the catalytically competent resting state of the catalyst, which was thought to contain a CoIV–oxyl complex. The electronic structure calculations suggest that the low‐spin doublet state is energetically most favorable, but the catalytically most active species is the intermediate‐spin quartet complex that is almost isoenergetic with the doublet state. The electronic structure of the quartet state shows significant spin polarization on the terminal oxygen atom, which is consistent with an intramolecular electron transfer from the oxygen to the metal. Based on the calculated spin densities, the formally [CoIV${^{\underline{.....}}}$O] can be viewed as a biradicaloid [CoII(⋅O⋅)]2+, that is, a cobalt–oxene moiety. This electronic structure is reminiscent of many other systems where similar electronic patterns were proposed to be responsible for the oxidative reactivity. In this context, this first‐row transition‐metal system constitutes a logical extension, because the oxyl‐radical character is maximized by using the more easily accessible high‐spin configurations in which two half‐filled Codπ orbitals can work in concert to maximize the oxyl‐radical character to ultimately afford a new reactive intermediate that can be characterized as carrying a biradicaloid oxene moiety with a formal oxidation state of zero. This conceptual proposal for the catalytically active species provides a plausible rationale for the remarkable oxidative reactivity.
Titania‐Supported Catalysts for Levulinic Acid Hydrogenation: Influence of Support and its Impact on γ‐Valerolactone Yield
Authors: Ruppert A. M. , Grams J. , Jędrzejczyk M. , Matras‐Michalska J. , Keller N. , Ostojska K. , Sautet P. 
Published: January 2015

AbstractA series of titania‐supported ruthenium and platinum catalysts was investigated in the levulinic acid hydrogenation towards γ‐valerolactone, a key reaction for the catalytic transformation of biomass. It was shown that various morphologies and phases of titania strongly influence the physicochemical and catalytic properties of supported Ru and Pt catalysts in different ways. In the case of the catalyst supported on mixed TiO2 phases, Ru particles are exclusively located on the minority rutile crystallites, whereas such an effect was not observed for platinum. The platinum catalyst activity could be increased when the metal was dispersed on the large surface‐area anatase, which was not the case for ruthenium as a result of its agglomeration on this support. The activity of ruthenium on anatase could be increased in two ways: a) when RuO2 formation during catalyst preparation was avoided; b) when pure anatase support material was modified so that it exhibited no microporosity. The obtained results allow a better understanding of the role of the support for Ru and Pt catalysts.
A hierarchical Bayesian model to estimate the unobservable predation rate on sawfly cocoons by small mammals
Authors: Pinkantayong Panisara , Suzuki Satoshi , Kubo Mamoru , Muramoto Ken‐ichiro , Kamata Naoto 
Published: January 2015

AbstractPredation by small mammals has been reported as an important mortality factor for the cocoons of sawfly species. However, it is difficult to provide an accurate estimate of newly spun cocoons and subsequent predation rates by small mammals for several reasons. First, all larvae do not spin cocoons at the same time. Second, cocoons are exposed to small mammal predation immediately after being spun. Third, the cocoons of the current generation are indistinguishable from those of the previous generation. We developed a hierarchical Bayesian model to estimate these values from annual one‐time soil sampling datasets. To apply this model to an actual data set, field surveys were conducted in eight stands of larch plantations in central Hokkaido (Japan) from 2009 to 2012. Ten 0.04‐m2 soil samples were annually collected from each site in mid‐October. The abundance of unopened cocoons (I), cocoons emptied by small‐mammal predation (M), and empty cocoons caused by something other than small‐mammal predation (H) were determined. The abundance of newly spun cocoons, the predation rate by small mammals before and after cocoon sampling, and the annual rate of empty cocoons that remained were estimated. A posterior predictive check yielded Bayesian P‐values of 0.54, 0.48, and 0.07 for I, M, and H, respectively. Estimated predation rates showed a significant positive correlation with the number of trap captures of small mammals. Estimates of the number of newly spun cocoons had a significant positive correlation with defoliation intensity. These results indicate that our model showed an acceptable fit, with reasonable estimates. Our model is expected to be widely applicable to all hymenopteran and lepidopteran insects that spin cocoons in soil.
Trends in the Synthesis and Functionalization of Guaianolides
Authors: Santana Alejandro , Molinillo José M. G. , Macías Francisco A. 
Published: January 2015

AbstractGuaianolides constitute a large and diverse group of biologically active sesquiterpenes. Guaianolide and seco‐guaianolides can also be used as, for example, scaffolds for the development of new active molecules that are readily accessible by synthetic methods. Nevertheless, these lactones often have complex structures that make their synthesis difficult. The aim of this microreview is to provide an overview of the developments in guaianolide synthesis by the two major synthetic strategies: semi‐synthesis and total synthesis. Partial and total syntheses of guaianolides are described, with particular emphasis placed on the methods reported in the last decade. The methods discussed include rearrangements, cycloadditions, ring‐closing metathesis, the use of transition‐metal catalysts, photochemical reactions, and other recently developed techniques as key steps.
Pericyclic Reactions of Azafulvenium Methides Bearing Internal Dipolarophiles – Synthesis of Chromene and Chromane Derivatives
Authors: Ribeiro Laia Fernanda M. , Soares Maria I. L. , Gomes Clara S. B. , Pinho e Melo Teresa M. V. D. 
Published: January 2015

AbstractThe reactivity of azafulvenium methides with internal dipolarophiles was explored as an approach to new chromene derivatives. 4,5‐Dimethoxycarbonyl‐ and 5‐ethoxycarbonyl‐4‐phenylazafulvenium methides with a prop‐2‐ynyloxyphenyl substituent are converted into 2‐[2‐(2H‐chromen‐8‐yl)vinyl]‐1H‐pyrroles through a sequence of rearrangements. 4,5‐Dimethoxycarbonylazafulvenium methide with a more‐activated dipolarophile as well as the more‐activated 5‐(trifluoromethyl)azafulvenium methide with an unactivated alkyne could be trapped by [8π+2π] cycloadditions to afford 8,12a‐dihydro‐6H‐chromeno[4,3‐e]indolizines. 5‐(Trifluoromethyl)azafulvenium methide with a 2‐(3‐methoxycarbonylprop‐2‐enyloxy)phenyl substituent at C‐1 participated in both intramolecular [8π+2π] and [4π+2π] cycloadditions to afford heterocycle‐fused chromanes. The microwave‐induced rearrangements of 3‐[2‐(prop‐2‐ynyloxy)phenyl]‐1H,3H‐pyrrolo[1,2‐c]thiazoles afforded chiral 3‐(2H‐chromen‐8‐yl)‐1H,3H‐pyrrolo[1,2‐c]thiazoles.
Solvent‐Induced Reversal of Enantioselectivity in the Synthesis of Succinimides by the Addition of Aldehydes to Maleimides Catalysed by Carbamate‐Monoprotected 1,2‐Diamines
Authors: Flores‐Ferrándiz Jesús , Fiser Béla , Gómez‐Bengoa Enrique , Chinchilla Rafael 
Published: January 2015

AbstractA simple change in the polarity of the solvent allows both enantiomers of substituted succinimides to be obtained in the enantioselective conjugate addition reaction of aldehydes, mainly α,α‐disubstituted, to maleimides catalysed by chiral carbamate‐monoprotected trans‐cyclohexane‐1,2‐diamines. Using a single enantiomer of the organocatalyst, both enantiomers of the resulting Michael adducts are obtained in high yields by simply changing the reaction solvent from aqueous DMF (up to 84 % ee) to chloroform (up to 86 % ee). Theoretical calculations are used to explain this uncommon reversal of the enantioselectivity; two transition state orientations of different polarities are differently favoured in polar or nonpolar solvents.
A Route to Benzo‐Annelated δ‐Sultams through Michael Cyclization
Authors: Grosheva Daria S. , Rassadin Valentin A. , Sokolov Victor V. 
Published: January 2015

AbstractA new approach to benzo‐annelated δ‐sultams containing an aryl–nitrogen bond is described. The method, which involves the intramolecular Michael cyclization of tert‐butyl ortho‐[N‐(methoxycarbonylmethyl)sulfonylamino]cinnamates, allows the synthesis of secondary sultams as well as their tertiary analogues and bridged tricyclic derivatives efficiently and diastereoselectively.