bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in Accommodating Volume Change of Si Anodes for Li‐Ion Batteries
Authors: Ko Minseong , Chae Sujong , Cho Jaephil 
Published: August 2015

AbstractSi has been considered as a promising alternative anode for next‐generation Li‐ion batteries (LIBs) because of its high theoretical energy density, relatively low working potential, and abundance in nature. However, Si anodes exhibit rapid capacity decay and an increase in the internal resistance, which are caused by the large volume changes upon Li insertion and extraction. This unfortunately limits their practical applications. Therefore, managing the total volume change remains a critical challenge for effectively alleviating the mechanical fractures and instability of solid‐electrolyte‐interphase products. In this regard, we review the recent progress in volume‐change‐accommodating Si electrodes and investigate their ingenious structures with significant improvements in the battery performance, including size‐controlled materials, patterned thin films, porous structures, shape‐preserving shell designs, and graphene composites. These representative approaches potentially overcome the large morphologic changes in the volume of Si anodes by securing the strain relaxation and structural integrity in the entire electrode. Finally, we propose perspectives and future challenges to realize the practical application of Si anodes in LIB systems.
Mesoporous‐Silica‐Functionalized Nanoparticles for Drug Delivery
Authors: Giret Simon , Wong Chi Man Michel , Carcel Carole 
Published: August 2015

AbstractThe ever‐growing interest for finding efficient and reliable methods for treatment of diseases has set a precedent for the design and synthesis of new functional hybrid materials, namely porous nanoparticles, for controlled drug delivery. Mesoporous silica nanoparticles (MSNPs) represent one of the most promising nanocarriers for drug delivery as they possess interesting chemical and physical properties, thermal and mechanical stabilities, and are biocompatibile. In particular, their easily functionalizable surface allows a large number of property modifications further improving their efficiency in this field. This Concept article deals with the advances on the novel methods of functionalizing MSNPs, inside or outside the pores, as well as within the walls, to produce efficient and smart drug carriers for therapy.
Assembly of a Complex Branched Oligosaccharide by Combining Fluorous‐Supported Synthesis and Stereoselective Glycosylations using Anomeric Sulfonium Ions
Authors: Huang Wei , Gao Qi , Boons Geert‐Jan 
Published: August 2015

AbstractThere is an urgent need to develop reliable strategies for the rapid assembly of complex oligosaccharides. This paper presents a set of strategically selected orthogonal protecting groups, glycosyl donors modified by a (S)‐phenylthiomethylbenzyl ether at C‐2, and a glycosyl acceptor containing a fluorous tag, which makes it possible to rapidly prepare complex branched oligosaccharides of biological importance. The C‐2 auxiliary controlled the 1,2‐cis anomeric selectivity of the various galactosylations. The orthogonal protecting groups, 2‐naphthylmethyl ether (Nap) and levulinic ester (Lev), made it possible to generate glycosyl acceptors and allowed the installation of a crowded branching point. After the glycosylations, the chiral auxiliary could be removed using acidic conditions, which was compatible with the presence of the orthogonal protecting groups Lev and Nap, thereby allowing the efficient installation of 1,2‐linked glycosides. The light fluorous tag made it possible to purify the compounds by a simple filtration method using silica gel modified by fluorocarbons. The set of building blocks was successfully employed for the preparation of the carbohydrate moiety of the GPI anchor of Trypanosoma brucei, which is a parasite that causes sleeping sickness in humans and similar diseases in domestic animals.
Coordination Properties of Perfluoroethyl‐ and Perfluorophenyl‐Substituted Phosphonous acids, RfP(OH)2
Authors: Allefeld Nadine , Kurscheid Boris , Neumann Beate , Stammler Hans‐Georg , Ignat'ev Nikolai , Hoge Berthold 
Published: August 2015

AbstractPhosphinic acids, RfP(O)(OH)H (Rf=CF3, C2F5, C6F5), turned out to be excellent preligands for the coordination of phosphonous acids, RfP(OH)2. Addition of C2F5P(O)(OH)H to solid PtCl2 under different reaction conditions allows the isolation and full characterization of the mononuclear complexes [ClPt{P(C2F5)(OH)O}{P(C2F5)(OH)2}2] and [Pt{P(C2F5)(OH)O}2{P(C2F5)(OH)2}] containing hydrogen‐bridged [RfP(OH)O]− and RfP(OH)2 units. Further deprotonation of [Pt{P(C2F5)(OH)O}2{P(C2F5)(OH)2}2] leads to the formation of the dianionic platinate, [Pt{P(C2F5)(OH)O}4]2−, revealing four intramolecular hydrogen bridges. With PdCl2 the dinuclear complex [Pd2(μ‐Cl)2{[P(C2F5)(OH)O]2H}2] was isolated and characterized. The Cl− free complex [Pd{P(C2F5)(OH)O}2{P(C2F5)(OH)2}2] was also prepared and deprotonated to the dianionic palladate, [Pd{P(C2F5)(OH)O}4]2−. Both compounds were characterized by NMR spectroscopy, IR spectroscopy, and X‐ray analyses. In addition, the C6F5 derivatives [ClPt{P(C6F5)(OH)O}{P(C6F5)(OH)2}2] and [Pd2(μ‐Cl)2{[P(C6F5)(OH)O]2H}2] as well as the CF3 derivative [Pd2(μ‐Cl)2{[P(CF3)(OH)O]2H}2] were synthesized and fully characterized. Phosphonous acid complexes are inert towards air and moisture and can be stored for several months without decomposition. The catalytic activity of the palladium complexes in the Suzuki cross‐coupling reaction between 1‐bromo‐3‐fluorobenzene and phenyl boronic acid was demonstrated.
Release of the Water Molecule Encapsulated Inside an Open‐Cage Fullerene through Hydrogen Bonding Mediated by Hydrogen Fluoride
Authors: Xu Liang , Ren Hongjiang , Liang Sisi , Sun Jiahao , Liu Yajun , Gan Liangbing 
Published: August 2015

AbstractA reversible wetting/dewetting procedure is reported for an open‐cage fullerene with an 18‐membered orifice. In a homogeneous mixture of H2O/EtOH/CHCl3, water was encapsulated into the cavity of the open‐cage compound quantitatively at 80 °C. Addition of aqueous hydrogen fluoride into the water‐encapsulated complex removed the encapsulated water completely at room temperature. H‐bonding between the trapped water and fluoride is shown to play a key role for the water release process.
ChemInform Abstract: Correlation Between the Electronic Structure, Effective Mass and Thermoelectric Properties of Rare Earth Tellurides Ba2MYTe5 (M: Ga, In).
Authors: Khan Wilayat , Borek Stephan , Minar Jan 
Published: August 2015

AbstractThe electronic structure, electronic charge density, and band gaps of Ba2MYTe5 (M: Ga, In) single crystals are simulated using the full potential linearized augmented plane wave package WIEN2k.
ChemInform Abstract: Tunable Luminescence and Energy Transfer Properties of a Novel Na4Ca4Si6O18:Ce3+, Mn2+ Phosphor.
Authors: Wei Dongxu , Sun Ying , Jiang Lianzhou , Hu Shaoxin , Li Dan 
Published: August 2015

AbstractColor‐tunable Ce3+, Mn2+ co‐doped Na4Ca4Si6O18 phosphors are prepared by solid‐state reaction of Na2CO3, CaCO3, SiO2, CeO2, and MnCO3 (1150 °C, 4 h in reducing CO atmosphere).
ChemInform Abstract: Synthesis, Crystal Structure and Properties of the Strontium Vanadate Fluoride Sr5(VO4)3F.
Authors: Zhang Fangyuan , Zhang Fangfang , Jing Qun , Pan Shilie , Yang Zhihua , Jia Dianzeng 
Published: August 2015

AbstractPolycrystalline samples of the title compound are synthesized by solid state reaction of stoichiometric mixtures of SrCO3, SrF2, and V2O5 (corundum crucible, 500 °C for 10 h and 700 °C for 24 h followed by sintering at 850 °C for 72 h).
ChemInform Abstract: Syntheses and Crystal Structures of BaAgTbS3, BaCuGdTe3, BaCuTbTe3, BaAgTbTe3, and CsAgUTe3.
Authors: Prakash Jai , Mesbah Adel , Beard Jessica C. , Ibers James A. 
Published: August 2015

AbstractSingle crystals of the new title compounds are prepared by reactions of stoichiometric amounts of the elements (1173—1273 K, 96—192 h, 70—80 wt.% yields based on Tb or Gd).
ChemInform Abstract: Enantioselective Ruthenium‐Catalyzed Carbonyl Allylation via Alkyne—Alcohol C—C Bond‐Forming Transfer Hydrogenation: Allene Hydrometalation vs. Oxidative Coupling.
Authors: Liang Tao , Nguyen Khoa D. , Zhang Wandi , Krische Michael J. 
Published: August 2015

AbstractThe first examples of enantioselective carbonyl allylation are presented.
ChemInform Abstract: Direct Asymmetric Amination of α‐Branched Cyclic Ketones Catalyzed by a Chiral Phosphoric Acid.
Authors: Yang Xiaoyu , Toste F. Dean 
Published: August 2015

AbstractAn asymmetric α‐amination of a variety of cyclic α‐substituted ketones using BINOL‐derived phosphoric acid (TCP) as catalyst provides the corresponding products with excellent enantioselectivities.
ChemInform Abstract: OH‐Directed Alkynylation of 2‐Vinylphenols with Ethynyl Benziodoxolones: A Fast Access to Terminal 1,3‐Enynes.
Authors: Finkbeiner Peter , Kloeckner Ulrich , Nachtsheim Boris J. 
Published: August 2015

AbstractThe first direct Rh‐catalyzed alkynylation of 2‐vinylphenols is developed using a hypervalent iodine reagent (II) as alkynyl transfer reagent.
ChemInform Abstract: Trifluoromethyl syn‐ or anti‐γ‐Amino Alcohols by One‐Pot Solvent‐Free Mannich‐Type Reactions under Temperature Control.
Authors: Fioravanti Stefania , Parise Luca , Pelagalli Alessia , Pellacani Lucio , Trulli Laura 
Published: August 2015

AbstractThe preparation of diastereomerically pure γ‐amino alcohols catalyzed by proline and derivatives thereof is examined: Depending on the amine used, performing the reaction at 25 or 40 °C provides only the syn‐isomeric products whereas at 0 °C the anti‐isomers are obtained.
ChemInform Abstract: Preparation of Tertiary Amines by the Reaction of Iminium Ions Derived from Unsymmetrical Aminals with Zinc and Magnesium Organometallics.
Authors: Werner Veronika , Ellwart Mario , Wagner Andreas J. , Knochel Paul 
Published: August 2015

AbstractA four‐step one‐pot procedure is elaborated for the preparation of tertiary amines (IV), (VII), and (X).
ChemInform Abstract: Expedient and Efficient One Pot Synthesis of Trifluoroethyl Ethers from Metal Free 2,4,6‐Tris‐(2,2,2‐trifluoro‐ethoxy)‐[1,3,5] Triazene.
Authors: Mangawa Shrawan Kumar , Sharma Chiranjeev , Kumar Singh Ashawani , Awasthi Satish K. 
Published: August 2015

AbstractVarious fluorinated alkyl and aryl ethers are eco‐friendly obtained using the synthetic non‐toxic, non‐ozone depleting, and stable 2,4,6‐tris‐(2,2,2‐trifluoroethoxy)‐[1,3,5]triazene (II) as trifluoroethylation reagent.
ChemInform Abstract: Visible Light Promoted Carbodifluoroalkylation of Allylic Alcohols via Concomitant 1,2‐Aryl Migration.
Authors: Xu Pan , Hu Kaidong , Gu Zhangxi , Cheng Yixiang , Zhu Chengjian 
Published: August 2015

AbstractThe photo‐induced difluoroalkylation of allylic alcohols in the presence of blue LED light affords difluoro 1,5‐dicarbonyl compounds through tandem radical addition and 1,2‐aryl migration.
ChemInform Abstract: The Discovery of a Novel Route to Highly Substituted α‐Tropolones Enables Expedient Entry to the Core of the Gukulenins.
Authors: Kats‐Kagan Roman , Herzon Seth B. 
Published: August 2015

AbstractThe thermal rearrangement of dibromides (I) proceeds with a ring expansion to afford a variety of substituted tropolones (II) in good to high yields.
ChemInform Abstract: Base‐Free Direct Formylation of Aromatic Iodides Using CO2 as C1 Source Catalyzed by Palladium Nanoparticles Grafted onto Amino‐Functionalized Nanostarch.
Authors: Kumar Subodh , Verma Sanny , Jain Suman L. 
Published: August 2015

AbstractIt is demonstrated for the first time that aromatic aldehydes can be directly formylated with CO2 as C1 carbon source under base free conditions.
ChemInform Abstract: Copper‐Catalyzed Tandem Synthesis of 2‐(Sulfonylimino)alkanamides from N‐Sulfonylketenimines and Alkyl Isocyanides.
Authors: Yavari Issa , Ghazanfarpour‐Darjani Majid , Nematpour Manijeh 
Published: August 2015

AbstractN‐Sulfonylketenimines generated in situ from alkynes and azides are trapped by isocyanides to give 2‐(sulfonylimino)alkanamides in a one‐pot manner.
ChemInform Abstract: Trifluoromethyl Sulfoxides from Allylic Alcohols and Electrophilic SCF3 Donor by [2,3]‐Sigmatropic Rearrangement.
Authors: Maeno Mayaka , Shibata Norio , Cahard Dominique 
Published: August 2015

AbstractElectrophilic trifluoromethylthiolation of allylic alcohols with N‐trifluoromethylthiosaccharin (Shen′s reagent) affords the corresponding allylic trifluoromethanesulfenates, which spontaneously rearrange into trifluoromethyl sulfoxides.
ChemInform Abstract: Synthesis of Carbodiimides by I2/CHP‐Mediated Cross‐Coupling Reaction of Isocyanides with Amines under Metal‐Free Conditions.
Authors: Zhu Tong‐Hao , Wang Shun‐Yi , Tao Yang‐Qing , Ji Shun‐Jun 
Published: August 2015

AbstractBoth symmetric and asymmetric functionalized carbodiimides can be synthesized using the title method.
ChemInform Abstract: Chlorosulfonic Acid Supported Diethylamine Ionic Liquid Catalyzed Green Synthesis of Novel 2‐Mercaptonaphthalen‐1‐yl (methyl)‐3‐hydroxy‐5,5‐dimethylcyclohex‐2‐enones under Neat Conditions.
Authors: Reddy Mudumala Veeranarayana , Chandra Sekhar Reddy Gangireddy , Naidu Kalla Reddi Mohan , Jeong Yeon Tae 
Published: August 2015

AbstractThe heterogeneous catalyst is environmentally benign, very active, and can be reused several times without significant loss of activity.
ChemInform Abstract: Reacting Cyclopropenones with Arynes: Access to Spirocyclic Xanthene—Cyclopropene Motifs.
Authors: Wallbaum Jan , Jones Peter G. , Werz Daniel B. 
Published: August 2015

AbstractAlkyl/aryl‐ and dialkyl‐substituted cyclopropenones do not react to the desired spirocyclic compounds under these conditions.
ChemInform Abstract: Bespoke SnAP Reagents for the Synthesis of C‐Substituted Spirocyclic and Bicyclic Saturated N‐Heterocycles.
Authors: Geoghegan Kimberly , Bode Jeffrey W. 
Published: August 2015

AbstractCyclization of stannyl amines with aldehydes utilizing the stannyl amine protocol (SnAP) leads to bicyclic and spirocyclic morpholines and piperazines.
ChemInform Abstract: Regio‐ and Chemoselective N‐1 Acylation of Indoles: Pd‐Catalyzed Domino Cyclization to Afford 1,2‐Fused Tricyclic Indole Scaffolds.
Authors: Liu Yongxian , Huang Yuanqiong , Song Hongjian , Liu Yuxiu , Wang Qingmin 
Published: August 2015

AbstractThe procedure allows access to various tricyclic N‐heterocycles which contain a diazepine unit.
ChemInform Abstract: Gold(I)‐Catalyzed Dearomative Rautenstrauch Rearrangement: Enantioselective Access to Cyclopenta[b]indoles.
Authors: Zi Weiwei , Wu Hongmiao , Toste F. Dean 
Published: August 2015

AbstractThe first gold‐catalyzed dearomative Rautenstrauch rearrangements of N‐tosyl indoles of type (I) and (V) are described.
ChemInform Abstract: Synthesis and Characterization of Asymmetric 1,2‐Dihydroxy‐5,5′‐bitetrazole and Selected Nitrogen‐Rich Derivatives.
Authors: Hafner Katherina , Klapoetke Thomas M. , Schmid Philipp C. , Stierstorfer Joerg 
Published: August 2015

AbstractA selective synthesis of the title compound from inexpensive starting materials is presented.
ChemInform Abstract: Metal‐Free Intramolecular Transannulation of N,3‐Diaryloxirane‐2‐carboxamides: A Concise and Versatile Route to 3‐Arylquinolin‐2(1H)‐ones.
Authors: Mamedov Vakhid A. , Mamedova Vera L. , Kadyrova Saniya F. , Khikmatova Gul'naz Z. , Gubaidullin Aidar T. , Rizvanov Il'dar Kh. , Latypov Shamil K. 
Published: August 2015

AbstractThe intramolecular transannulation of trans‐epoxides (III) towards quinolinones (IV) proceeds via a Meinwald rearrangement and Friedel—Crafts alkylation processes, featuring an exclusive 1,2‐aryl migration.
ChemInform Abstract: Rh(III) and Ru(II)‐Catalyzed Site‐Selective C—H Alkynylation of Quinolones.
Authors: Kang Dahye , Hong Sungwoo 
Published: August 2015

Abstract4‐Quinolinones are alkynylated regioselectively with (silylethynyl)benziodoxolone by using rhodium or ruthenium catalysts.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Annulation of Cyclic β‐Enamino Esters with Enals: Access to Functionalized Indolo[2,3‐a]quinolizidines.
Authors: Hu Shihe , Wang Bingyang , Zhang Yu , Tang Weifang , Fang Mengyuan , Lu Tao , Du Ding 
Published: August 2015

AbstractA novel approach for the quick and efficient construction of the indolo[2,3‐a]quinolizidine skeleton, a core structure of many biologically active natural products, is developed.
ChemInform Abstract: Gold‐Catalyzed Tandem Hydroamination/Formal Aza‐Diels—Alder Reaction of Homopropargyl Amino Esters: A Combined Computational and Experimental Mechanistic Study.
Authors: Miro Javier , Sanchez‐Rosello Maria , Gonzalez Javier , del Pozo Carlos , Fustero Santos 
Published: August 2015

AbstractUnder optimized conditions, the title reaction leads to formation of a tetracyclic nitrogen‐containing framework with generation of 4 bonds and 5 stereocenters.
ChemInform Abstract: Microwave‐Assisted Palladium‐Catalyzed Isonitrile Insertion in 2‐Bromophenylureas for Efficient Synthesis of 4‐Substituted Imino 4H‐Benzo[d][1,3]oxazin‐2‐amines.
Authors: Pandey Garima , Batra Sanjay 
Published: August 2015

AbstractThe reaction tolerates aromatic and aliphatic 2‐bromophenylureas as well as aryl, alkyl, and sulfonyl group containing isocyanides.
ChemInform Abstract: Nickel‐Catalyzed P—C Bond Formation via P—H/C—CN Cross Coupling Reactions.
Authors: Zhang Ji‐Shu , Chen Tieqiao , Yang Jia , Han Li‐Biao 
Published: August 2015

AbstractArylphosphine oxides (III) and (V) as well as arylphosphines (VII) are readily prepared by a Ni‐catalyzed cross‐coupling of aryl nitriles with the corresponding P—H compounds.
ChemInform Abstract: Broensted Acid‐Catalyzed Phenylselenenylation of Internal Olefins.
Authors: Wu Ping , Huang Fei , Lou Jiang , Wang Quannan , Liu Zhuqing , Yu Zhengkun 
Published: August 2015

AbstractTreatment of olefins (I) and (VI) with phenylseleno reagent (II) affords selenated products.
ChemInform Abstract: Flash Chemistry Using Trichlorovinyllithium: Switching the Reaction Pathways by High‐Resolution Reaction Time Control.
Authors: Nagaki Aiichiro , Takahashi Yusuke , Henseler Andrea , Matsuo Chika , Yoshida Jun‐ichi 
Published: August 2015

AbstractDifferent types of products are obtained from a single parent compound in a flow microreactor system by control of the residence times.
ChemInform Abstract: Reaction Integration Using Electrogenerated Cationic Intermediates
Authors: Yoshida Jun‐ichi , Shimizu Akihiro , Ashikari Yosuke , Morofuji Tatsuya , Hayashi Ryutaro , Nokami Toshiki , Nagaki Aiichiro 
Published: August 2015

AbstractReview: [37 refs.
ChemInform Abstract: From the Sabatier Principle to a Predictive Theory of Transition‐Metal Heterogeneous Catalysis
Authors: Medford Andrew J. , Vojvodic Aleksandra , Hummelshoej Jens S. , Voss Johannes , Abild‐Pedersen Frank , Studt Felix , Bligaard Thomas , Nilsson Anders , Noerskov Jens K. 
Published: August 2015

AbstractReview: 56 refs.
Competitor identification, perceived environmental uncertainty, and firm performance
Authors: Yu Chung‐Long , Wang Fatima , Brouthers Keith D. 
Published: August 2015

AbstractTo create a competitive advantage and generate superior performance, firms must first identify rivals. However, there is little understanding of how perceived environmental uncertainty affects competitor identification, why some firms are better at identifying domestic versus foreign rivals, or how competitor identification is related to firm performance. In this paper we theorize that perceived environmental uncertainty is an important antecedent of competitor identification; it influences how many competitors a firm identifies. Our theory also suggests that different firm characteristics influence domestic/foreign competitor identification and that there is an inverted‐U shaped relationship between under/overidentification of competitors and firm performance. Based on a large sample of Taiwanese firms, we find support for each of these ideas. Our study helps reinforce the importance of competitor identification for firm success. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.
Risk stratification in patients with advanced‐stage breast cancer by pretreatment [18F]FDG PET/CT
Authors: Chen Suyun , Ibrahim Nuhad K. , Yan Yuanqing , Wong Stephen T. , Wang Hui , Wong Franklin C. 
Published: August 2015

BACKGROUNDThe objective of the current study was to investigate the prognostic value of pretreatment [18F] fluorodeoxyglucose position emission tomography/computed tomography ([18F]FDG PET/CT) in patients with advanced‐stage breast cancer.METHODSPretreatment PET/CT scans from 240 consecutive patients with American Joint Committee on Cancer stage III or stage IV BC were analyzed retrospectively. Clinicopathological factors and metabolic parameters of the primary tumor including maximum standardized uptake value (SUVmax), metabolic tumor volume, and total lesion glycolysis (TLG) with a range of thresholds were compared to predict progression‐free survival (PFS) and overall survival (OS) using a time‐dependent receiver operating characteristic curve and Cox proportional hazards regression analyses.RESULTSSUVmax with a cutoff value of 6.0, TLG30% with a cutoff value of 158 g, and phenotype associated with PFS and OS were analyzed using multivariate analysis. The mean TLG30% of primary tumors for patients with stage III and stage IV disease was 405 g and 750 g (P = .010), respectively. Patients with triple‐negative breast cancer or a TLG30% >158 g or with both were categorized as being at high risk, and those with non‐triple‐negative breast cancer and a primary tumor with a TLG30% ≤158 g were defined as low risk. The 5‐year PFS rates for stage III disease among patients with low‐risk versus high‐risk BC were 85% and 67.5%, respectively. For patients with stage IV disease, the 5‐year PFS rates were 45% and 9%, respectively, for patients with low‐risk versus high‐risk disease. Patients with stage III and high‐risk BC had OS rates that were similar to those for patients with stage IV and low‐risk BC (P = .552).CONCLUSIONSThe TLG30% from pretreatment PET/CT was found to independently correlate with survival outcomes and appears to be able to effectively stratify both patients with stage III and those with stage IV BC. Cancer 2015;121:3965–3974. © 2015 American Cancer Society.
Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL
Authors: de la Peña Amparo , Seger Mary , Soon Danny , Scott Adam J. , Reddy Shobha R. , Dobbins Michael A. , Brown‐Augsburger Patricia , Linnebjerg Helle 
Published: August 2015

AbstractInsulin lispro 200 U/mL (IL200) is a new strength formulation of insulin lispro (Humalog®, IL100), developed as an option for diabetic patients on higher daily mealtime insulin doses. This phase 1, open‐label, 2‐sequence, 4‐period crossover, randomized, 8‐hour euglycemic clamp study aimed to demonstrate the bioequivalence of IL200 and IL100 after subcutaneous administration of 20 U (U) to healthy subjects (n = 38). Pharmacokinetic (PK) and pharmacodynamic (PD) responses were similar in both formulations. All 90%CIs for the ratios of area under the concentration‐versus‐time curve from time zero to the time of the last measurable concentration (AUC0–tlast) and maximum observed drug concentration (Cmax), as well as the total glucose infused throughout the clamp (Gtot) and the maximum glucose infusion rate (Rmax), were contained within 0.80 and 1.25. Time of maximum observed drug concentration (tmax) was similar between formulations, with a median difference of 15 minutes and a 95%CI of the difference that included zero. Inter‐ and intrasubject variability estimates were similar for both formulations. Both formulations were well tolerated. IL200 was bioequivalent to IL100 after subcutaneous administration of 20‐U single doses, and PD responses were comparable between formulation strengths.