bluuebunny/crossref_metadata_2025_split huggingface dataset:
Une ontologie multidomaine des événements. Noms d'événements comme noms d'étendues
Authors: Tauveron Matthias 
Published: January 2015

Résumé L’emploi de noms d’actions avec des verbes à argument pluriel (ainsi l’action se disperse , le verbe se disperser prenant en principe un sujet pluriel ou collectif) conduit à s’interroger sur la configuration des référents qu’ils dénotent, dans la lignée des travaux sur les noms massifs, comptables, collectifs (par exemple Nicolas 2002). Nous proposerons dans un premier temps l’hypothèse du statut de nom collectif abstrait pour cet emploi de action . C’est cependant une seconde hypothèse, reposant sur la catégorie des noms de lieux étendus ( jungle , toundra ) décrite par Asnès 2004, qui est la plus fructueuse. Nous la généralisons aux noms d’actions sous la forme d’une catégorie de « noms d’étendues ». De surcroît, considérer les noms d’actions comme des noms d’étendues permet de montrer que leurs référents ont une ontologie multidomaine (dans la définition de Langacker 1987) dont nous évoquons les grands traits : temporel, spatial et deux domaines notionnels (plan de l’action, thème sur lequel elle porte).
Les pronoms cataphoriques sujets dans les subordonnées temporelles antéposées. De la phrase au discours
Authors: Dos Santos Fonseca Cristina 
Published: January 2015

Résumé : La cataphore demeure un phénomène sous-documenté par rapport à l’anaphore. Les travaux en grammaire générative expliquent la coïndexation cataphorique des pronoms en termes syntaxiques. D’autres études avancent que les SN possessifs et les pronoms sujets cataphoriques obéissent à des choix stylistiques ou s’inscrivent dans une procédure de rappel du référent (Kuno 1975). Des études sur corpus en anglais (Carden 1982 ; Van Hoek 1997) invalident cette thèse et montrent que la majorité des expressions cataphoriques apparaissent dans des subordonnées temporelles antéposées et dans des SP antéposés. En français, il n’existe pas d’études sur la fréquence des pronoms cataphoriques. À partir d’un corpus constitué de textes extraits du Monde diplomatique datant de 1984-1998, nous donnons un aperçu de la fréquence des pronoms cataphoriques dans des subordonnées antéposées introduites par « quand » et nous les distinguons des pronoms anaphoriques. Nous dégageons aussi les contextes dans lesquels apparaissent les pronoms cataphoriques et les pronoms anaphoriques.
Retrospective Comparisons of Vitrectomy With and Without Air Tamponade to Repair Lamellar Macular Hole
Authors: Sato Tatsuhiko , Emi Kazuyuki , Bando Hajime , Ikeda Toshihide 
Published: January 2015

BACKGROUND AND OBJECTIVE:
To investigate the surgical outcomes of vitrectomy with to that without air tamponade in eyes with a lamellar macular hole.

PATIENTS AND METHODS:
The medical records of 23 eyes that underwent 25-gauge vitrectomy with air tamponade and 18 eyes that underwent 25-gauge vitrectomy alone were reviewed.

RESULTS:

The pre- and postoperative best corrected visual acuities (BCVAs) in logarithm of the minimum angle resolution units were 0.26 ± 0.27 and 0.12 ± 0.15 in eyes with tamponade and 0.35 ± 0.30 and 0.14 ± 0.23 in eyes without tamponade. There were no significant differences in BCVAs between the two groups both pre- and postoperatively. Postoperative BCVA was significantly improved in eyes with tamponade (
P
= .023) and without tamponade (
P
< .001). None of the cases developed a full-thickness macular hole postoperatively.

CONCLUSION:
These results suggest that air tamponade may not be required during vitrectomy to achieve good BCVA and anatomic closure in eyes with a lamellar macular hole.

[
Ophthalmic Surg Lasers Imaging Retina
. 2015;46:38–43.]
Cost Comparison of Intravitreal Aflibercept With Bevacizumab and Ranibizumab for the Treatment of Wet Age-Related Macular Degeneration
Authors: Shaikh Adeel H. , Toussaint Brian W. , Miller Daniel M. , Petersen Michael R. , Foster Robert E. , Riemann Christopher D. , Hutchins Robert K. , Sisk Robert A. 
Published: January 2015

BACKGROUND AND OBJECTIVE:
To test the hypothesis that although intravitreal aflibercept (IVA) is expected to be more expensive, the extra cost of treatment would not result in additional vision gain compared with intravitreal bevacizumab (IVB) for the treatment of wet age-related macular degeneration (AMD).

PATIENTS AND METHODS:
A retrospective chart review of patients receiving IVB or intravitreal ranibizumab (IVR) who were subsequently changed to IVA for active wet AMD.

RESULTS:
Thirty-three eyes were included in the study. The mean number of IVB, IVR, and IVA injections per eye over a 6-month period was seven, six, and five, respectively. Visual outcomes were similar in all three groups at the end of the study period. The average drug cost of IVB, IVR, and IVA injections per eye over 6 months was $326, $11,400, and $9,720, respectively.

CONCLUSION:
Aflibercept may allow a modest extension of the treatment interval, but cost makes IVA an expensive alternative without a visual benefit compared with IVB in patients with active wet AMD.

[
Ophthalmic Surg Lasers Imaging Retina
. 2015;46:62–66.]
Trimanual Technique Using Assistant-Controlled Light Probe Illumination and Wide-Angle Viewing System in 23-Gauge Sutureless Vitrectomy for Diabetic Tractional Retinal Detachment
Authors: Moon Hoseok , Lee Dae Yeong , Nam Dong Heun 
Published: January 2015

BACKGROUND AND OBJECTIVE:
The authors propose a novel trimanual vitreous surgery using assistant-adjusted endoillumination during 23-gauge sutureless vitrectomy for severe diabetic tractional retinal detachment (TRD) under noncontact wide-angle viewing system.

MATERIALS AND METHODS:
The trimanual sutureless vitrectomy under a wide-angle viewing system consisted of (1) a fourth-port microcannula in the inferior 6-o’clock position; (2) dynamic and specular illumination by an assistant-controlled light probe inserted through the fourth port; and (3) membrane dissection and bleeding control using two intraocular instruments.

RESULTS:
Six eyes of four patients who underwent trimanual diabetic vitrectomy were evaluated. Recurrent TRD was detected in one eye, and a second operation was performed. There were no intraoperative sclerotomy-related complications or postoperative hypotony, increased IOP, or endophthalmitis. Final anatomic and functional success was achieved in all six eyes.

CONCLUSION:
The trimanual technique is valuable for membrane dissection in severe diabetic TRD. The optimal and dynamic illumination provided a high-quality stereoscopic view under a wide-angle viewing system. Careful coordination between a surgeon and an assistant facilitates this technique.

[
Ophthalmic Surg Lasers Imaging Retina.
2015;46:73–76.]
Physicians′ perception about electronic medical record system in Makkah Region, Saudi Arabia
Authors: Shaker Hani Abdulsattar , Farooq Mian Usman , Dhafar Khalid Obeid 
Published: January 2015

Abstract
Objectives: The study was done to determine the physicians′ perception about electronic medical record system (EMRS) in the context of its productivity in order to improve its functionality and advantages. Materials and Methods: This cross-sectional survey was performed from July to August 2009 with structured questionnaire of 15 closed-ended questions with five points Likert scaling starting from strongly disagree to strongly agree as 1-5, reflecting the perception of physicians about EMRS. The physicians of the Makkah region working in six different hospitals were selected. "Positive" response means if percent of responses were rated 4 or 5 (agree/strongly agree), "neutral" if rated 3, and negative if rated 1 or 2 (strongly disagree/disagree). Descriptive data analysis techniques were used. Results: We selected 317 completed questionnaires. Majority of subjects were from King Fahd Hospital, Jeddah (83, 26.3%), residents (147, 46.4%), male (200,63.1%), expatriates (207, 65%), and age group 36-45 years (133, 42%) were dominant. The stem regarding importance of computers for practicing medicine and EMRS to improve quality of practice was appreciated by majority, that is, 77.7 and 71.2%, respectively. However, "It does not disrupt the workflow" (35.1%) and "EMRS is comfortable while entering the data instead of writing" (34.8%) were appreciated negatively. Consultants (53.9%), male (53.4%), expatriates (56.7%), physicians of King Abdul Aziz Hospital, Ta′if (56.9%), and age group of 46-55 years (53.8%) appreciated EMRS positively. Overall perception of EMRS was found positive by 52.8%. Conclusion: Majority appreciated the EMRS, but specific concerns about its usage easiness and workflow disturbance were opposed by them also.
Self-Assessment and Personalization in Occupational Therapy Services: A Managerial Perspective on the Challenges and Opportunities of a Service Innovation
Authors: Abendstern Michele , Hughes Jane , Tucker Sue , Clarkson Paul , Challis David 
Published: January 2015

Introduction: This article examines the introduction of self-assessment in occupational therapy services, focusing on the impact of new tools and approaches on professional culture and practice. Method: Qualitative data were collected via interviews with managers of five pilot projects and analysed using a mixture of predetermined and emergent themes. Findings: Within the implementation process, challenges and opportunities were identified, including the development of web-based assessment tools, extending the roles of staff groups not previously engaged in assessment, and refocusing the duties of qualified staff on the most complex cases. The involvement of staff in the design of new tools, bespoke training courses, and the use of ‘champions’ were reported to be effective means of supporting them through the change process. The development of new ways of delivering services through new technology was found to be in its infancy. Conclusion: Self-assessment complemented professional practice in occupational therapy services. It enabled the skills of qualified staff to be used appropriately whilst ensuring that people with needs requiring simple interventions had greater opportunity than previously to take charge of their situation and to receive a timely service that was tailored to their needs. New technology required further development to enhance service delivery.
The Integrating Theory, Evidence and Action (ITEA) Method: A Procedure for Helping Practitioners Translate Theory and Research into Action
Authors: Hitch Danielle , Pepin Genevieve , Stagnitti Karen 
Published: January 2015

Introduction The aim of this article is to describe and explain a new method for integrating theory and evidence that enables practitioners to translate evidence into action applied in their practice. Method A new multiple methods procedure called the Integrating Theory, Evidence and Action method is described. It is a mixed method that progresses through seven distinct steps: clinical question, framework, identification, deconstruction, analysis, reconstruction, and transfer/utilization. An example of using this method to review evidence around occupational therapy with people recovering from alcohol misuse and/or abuse is provided. Findings This method highlights the importance of theory, tests the empirical strength of theories, includes diverse forms of evidence, and encourages the integration of knowledge within clinical practice. Conclusion The Integrating Theory, Evidence and Action method is accessible and useful to practitioners and will support their efforts to make their practice evidence based. Current methods of evidence-based practice focus mostly on research evidence (particularly quantitative evidence); however, research is only one of the ways of knowing that practitioners draw upon to guide their practice. This method enables occupational therapists to integrate theory, evidence, and practice in a coherent and translatable way.
Gender Differences in Students' Self-Awareness of Their Handwriting Performance
Authors: Lahav Orit , Maeir Adina , Weintraub Naomi 
Published: January 2015

Introduction Self-awareness has been found to be an important factor in individuals' performance in daily activities. Yet, to date, the relationship between this factor and handwriting performance has not been examined. The purpose of this study was to compare the handwriting self-awareness (that is, self-knowledge and on-line awareness) and performance of girls and boys, and to examine the relationship between self-awareness and handwriting performance. Method Participants included 86 middle-school students (aged 12–14) enrolled in general education in Israel. A handwriting evaluation assessment was administered along with self-knowledge and on-line awareness questionnaires. Results Gender differences were found in relation to students' self-awareness of their handwriting performance. In comparison with girls, boys perceived their handwriting to be faster, even though their actual handwriting performance was slower. Regarding legibility, only boys showed a significant correlation between self-knowledge and performance, while both genders demonstrated significant correlations between on-line awareness and performance. Conclusion It appears that students aged 12–14 are only moderately aware of their handwriting performance, yet there are gender differences in relation to this awareness. These findings may assist educators and therapists in teaching, evaluating, and developing interventions to improve handwriting performance.
Sexual Orientation and Occupation: Some Issues to Consider When Working with Older Gay People to Meet Their Occupational Needs
Authors: Twinley Rebecca 
Published: January 2015

The surge of people now entering their older adult lives in many societies, including the United Kingdom, makes understanding and meeting the occupational needs of this population paramount. For many older gay people, growing up presented a unique set of challenges, some of which may still be experienced as barriers to realizing and/or overcoming their occupational needs. Sexual orientation is understood as one of many factors that can impact upon the individual experience of occupation and justice, and this opinion piece highlights four of the potential threats to occupational justice for some older gay people. It proposes that such challenges have triggered associated occupational needs for some older gay people — needs that remain largely obscure and unrecognized in occupational therapy literature. Please note: The term ‘gay’ has been chosen for the purpose of this opinion piece to refer to anyone who has intimate same-sex relationships or feelings.
The feasibility of using compression bioimpedance measurements to quantify peripheral edema
Authors: Koziol Leo , Pitre John J. , Bull Joseph L. , Dodde Robert E. , Kruger Grant , Vollmer Alan , Weitzel William F. 
Published: January 2015

Abstract
The accurate assessment of body fluid volume is important in many clinical situations, especially in the determination of “dry weight” in a dialysis setting. Currently, no clinically applicable diagnostic system exists to determine the mechanical properties that accurately characterize peripheral edema in an objective and quantitative manner. We have developed a method for quantifying the impact of compression on the electrical properties of tissue by measuring stress-induced changes in bioimpedance (BIS). Using this method, we simultaneously measured the impedance and mechanical response of a tissue mimicking material (tofu) under both quasi-static and dynamic loading conditions. Our results demonstrate a temporal quantification of viscoelastic properties using a viscoelastic phantom tissue model.
Safety and Feasibility for Pediatric Cardiac Regeneration Using Epicardial Delivery of Autologous Umbilical Cord Blood-Derived Mononuclear Cells Established in a Porcine Model System
Authors: Cantero Peral Susana , Burkhart Harold M. , Oommen Saji , Yamada Satsuki , Nyberg Scott L. , Li Xing , O'Leary Patrick W. , Terzic Andre , Cannon Bryan C. , Nelson Timothy J. ,   Wanek Program Porcine Pipeline Group
Published: January 2015

Abstract

Congenital heart diseases (CHDs) requiring surgical palliation mandate new treatment strategies to optimize long-term outcomes. Despite the mounting evidence of cardiac regeneration, there are no long-term safety studies of autologous cell-based transplantation in the pediatric setting. We aimed to establish a porcine pipeline to evaluate the feasibility and long-term safety of autologous umbilical cord blood mononuclear cells (UCB-MNCs) transplanted into the right ventricle (RV) of juvenile porcine hearts. Piglets were born by caesarean section to enable UCB collection. Upon meeting release criteria, 12 animals were randomized in a double-blinded fashion prior to surgical delivery of test article (n = 6) or placebo (n = 6). The UCB-MNC (3 × 106 cells per kilogram) or control (dimethyl sulfoxide, 10%) products were injected intramyocardially into the RV under direct visualization. The cohorts were monitored for 3 months after product delivery with assessments of cardiac performance, rhythm, and serial cardiac biochemical markers, followed by terminal necropsy. No mortalities were associated with intramyocardial delivery of UCB-MNCs or placebo. Two animals from the placebo group developed local skin infection after surgery that responded to antibiotic treatment. Electrophysiological assessments revealed no arrhythmias in either group throughout the 3-month study. Two animals in the cell-therapy group had transient, subclinical dysrhythmia in the perioperative period, likely because of an exaggerated response to anesthesia. Overall, this study demonstrated that autologous UCB-MNCs can be safely collected and surgically delivered in a pediatric setting. The safety profile establishes the foundation for cell-based therapy directed at the RV of juvenile hearts and aims to accelerate cell-based therapies toward clinical trials for CHD.
Non‐isotopic RNA In Situ Hybridization on Embryonic Sections
Authors: Touahri Yacine , Adnani Lata , Mattar Pierre , Markham Kathryn , Klenin Natalia , Schuurmans Carol 
Published: January 2015

AbstractThis unit describes methods for non‐isotopic RNA in situ hybridization on embryonic mouse sections. These methods can be used to follow the spatiotemporal dynamics of gene expression in an embryonic tissue of interest. They involve the use of labeled (e.g., digoxygenin, FITC) antisense riboprobes that hybridize to a specific mRNA in the target tissue. The probes are detected using an alkaline phosphatase−conjugated antibody recognizing the label and a chromogenic substrate. This method can be used to: (1) assess the expression of a single gene within a tissue, (2) compare the expression profiles of two genes within a tissue, or (3) compare the distribution of a transcript and protein within a tissue. While this approach is not quantitative, it provides a qualitative assessment of the precise cell types where a gene is expressed, which is not easily achievable with other more quantitative methods such as quantitative PCR. © 2015 by John Wiley & Sons, Inc.
Imaging the Insertion of Superecliptic pHluorin‐Labeled Dopamine D2 Receptor Using Total Internal Reflection Fluorescence Microscopy
Authors: Daly Kathryn M. , Li Yun , Lin Da‐Ting 
Published: January 2015

AbstractA better understanding of mechanisms governing receptor insertion to the plasma membrane (PM) requires an experimental approach with excellent spatial and temporal resolutions. Here we present a strategy that enables dynamic visualization of insertion events for dopamine D2 receptors into the PM. This approach includes tagging a pH‐sensitive GFP, superecliptic pHluorin, to the extracellular domain of the receptor. By imaging pHluorin‐tagged receptors under total internal reflection fluorescence microscopy (TIRFM), we were able to directly visualize individual receptor insertion events into the PM in cultured neurons. This novel imaging approach can be applied to both secreted proteins and many membrane proteins with an extracellular domain labeled with superecliptic pHluorin, and will ultimately allow for detailed dissections of the key mechanisms governing secretion of soluble proteins or the insertion of different membrane proteins to the PM. © 2015 by John Wiley & Sons, Inc.
To Stress or Not to Stress: A Question of Models
Authors: Gray J. Megan , Chaouloff Francis , Hill Matthew N. 
Published: January 2015

AbstractStress research is a rapidly evolving field that encompasses numerous disciplines ranging from neuroscience to metabolism. With many new researchers migrating into the field, navigating the hows and whys of specific research questions can sometimes be enigmatic given the availability of so many models in the stress field. Additionally, as with every field, there are many seemingly minor experimental details that can have dramatic influences on data interpretation, although many of these are unknown to those not familiar with the field. The aim of this overview is to provide some suggestions and points to guide researchers moving into the stress field and highlight relevant methodological points that they should consider when choosing a model for stress and deciding how to structure a study. We briefly provide a primer on the basics of endpoint measurements in the stress field, factors to consider when choosing a model for acute stress, the difference between repeated and chronic stress, and importantly, influencing variables that modulate endpoints of analysis in stress work. © 2015 by John Wiley & Sons, Inc.
ATAC‐seq: A Method for Assaying Chromatin Accessibility Genome‐Wide
Authors: Buenrostro Jason D. , Wu Beijing , Chang Howard Y. , Greenleaf William J. 
Published: January 2015

AbstractThis unit describes Assay for Transposase‐Accessible Chromatin with high‐throughput sequencing (ATAC‐seq), a method for mapping chromatin accessibility genome‐wide. This method probes DNA accessibility with hyperactive Tn5 transposase, which inserts sequencing adapters into accessible regions of chromatin. Sequencing reads can then be used to infer regions of increased accessibility, as well as to map regions of transcription‐factor binding and nucleosome position. The method is a fast and sensitive alternative to DNase‐seq for assaying chromatin accessibility genome‐wide, or to MNase‐seq for assaying nucleosome positions in accessible regions of the genome. © 2015 by John Wiley & Sons, Inc.
Quantification of Th1 and Th17 Cells with Intracellular Staining Following PMA/Ionomycin Stimulation
Authors: Karlsson Fridrik , Hassan‐Zahraee Mina 
Published: January 2015

AbstractCytokine‐producing cells are at the center of the adaptive immune responses, and quantifying these cells is an important aspect to build understanding of the immune response. In particular, Th1 and Th17 cells have been implicated in the pathogenesis of such diseases as inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis. Quantification of Th1 and Th17 cells can provide important information in research of these diseases and other Th1‐ and Th17‐mediated immune disorders. In vitro stimulation of cells followed by surface and intracellular staining, presented here, has the advantage of detecting the cytokines directly instead of relying exclusively on surrogate surface markers which, although showing enrichment for the effector T cells, are not specific markers for the cytokine‐producing cells. © 2015 by John Wiley & Sons, Inc.