bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxidative Coupling of an Enaminoporphyrin: C−C, N−N Linkages or Both?
Authors: Jimenez Angel J. , Mesa Noelia Sabater , Pereira Ana Mafalda V. M. , Jean Marion , Vincent Bruno , Jeandon Christophe , Gisselbrecht Jean‐Paul , Ruppert Romain 
Published: August 2015

AbstractA symmetrical bis‐nickelporphyrin was prepared in very good yield by oxidative coupling of a nickel(II) enaminoporphyrin. This dimer was obtained by the intermolecular reaction of the starting enamine (acting as nucleophile) with the porphyrin radical cation (acting as electrophile) generated in situ. Alternatively, by using different reaction conditions, an N−N linked porphyrin dimer was obtained in moderate yield. The monomeric extended porphyrin leading to the N−N linked dimer was obtained by the intramolecular reaction of the same radical cation with the neighbouring meso‐aryl group (acting as nucleophile).
Ongoing Pursuit of Diterpenoid Alkaloids: A Synthetic View
Authors: Liu Xiao‐Yu , Qin Yong 
Published: August 2015

AbstractThe incorporation of nitrogen atoms into policyclic diterpenes has led to one of the most fascinating group of natural products with cage‐like structures: diterpenoid alkaloids. Their singular architectural features and significant bioactivities made them highly pursued targets amongst the synthetic community over decades. A total of seven types of diterpenoid alkaloid molecules have been synthesized thus far, and the research in this area experienced a new climax in the past five years. With a brief overview and summary of the historic achievements, this Focus Review particularly covers the recent, post‐2010 advances in the field of diterpenoid alkaloid synthesis, highlighting the utilization of innovative synthetic methods and strategies. Despite numerous achievements, there are still a number of such alkaloids with different and unique structural types waiting to be accomplished, implying that the pursuit is far from ending.
Carbon isotope ratios of human tooth enamel record the evidence of terrestrial resource consumption during the Jomon period, Japan
Authors: Kusaka Soichiro , Uno Kevin T. , Nakano Takanori , Nakatsukasa Masato , Cerling Thure E. 
Published: August 2015

ABSTRACTObjective:Archaeological remains strongly suggest that the Holocene Japanese hunter‐gatherers, the Jomon people, utilized terrestrial plants as their primary food source. However, carbon and nitrogen isotope analysis of bone collagen indicates that they primarily exploited marine resources. We hypothesize that this inconsistency stems from the route of protein synthesis and the different proportions of protein‐derived carbon in tooth enamel versus bone collagen. Carbon isotope ratios from bone collagen reflect that of dietary protein and may provide a biased signal of diet, whereas isotope ratios from tooth enamel reflect the integrated diet from all macronutrients (carbohydrates, lipids, and proteins).Methods:In order to evaluate the differences in inferred diet between the archaeological evidence and bone collagen isotope data, this study investigated carbon isotopes in Jomon tooth enamel from four coastal sites of the Middle to Late–Final Jomon period (5,000–2,300 years BP).Results:Carbon isotope ratios of human teeth are as depleted as coeval terrestrial mammals, suggesting that C3 plants and terrestrial mammals were major dietary resources for the Jomon people. Dietary dependence on marine resources calculated from enamel was significantly lower than that calculated from bone collagen. The discrepancy in isotopic ratios between enamel and collagen and the nitrogen isotope ratio in collagen shows a negative correlation on individual and population levels, suggesting diets with variable proportions of terrestrial and marine resources.Conclusion:This study highlights the usefulness of coupling tooth enamel and bone collagen in carbon isotopic studies to reconstruct prehistoric human diet. Am J Phys Anthropol 158:300–311, 2015. © 2015 Wiley Periodicals, Inc.
The Economic Impact of the Mining Boom on Indigenous and Non‐Indigenous Australians
Authors: Hunter Boyd , Howlett Monica , Gray Matthew 
Published: August 2015

AbstractMany mining operations are on or near Indigenous land, and the strong level of investment during the recent mining boom may have disproportionately affected Indigenous communities. This article examines changes in local Indigenous employment, income and housing costs to identify any localised ‘resource curse’ for Indigenous communities and the Australian population at large. Census data are used to show the mining boom has improved employment and income outcomes, but increased average housing costs. While the average increase in income has generally offset the increase in costs, housing stress for low‐income households has increased as a result of the mining boom.
A NONOVARY‐SPECIFIC VITELLOGENIN RECEPTOR FROM THE ORIENTAL FRUIT FLY, Bactrocera dorsalis (HENDEL)
Authors: Lin Wei‐Jen , Chien Ching‐Yi , Tsai Cheng‐Lung , Chen Mei‐Er 
Published: August 2015

ABSTRACTThe yolk protein precursor, vitellogenin (Vg), is absorbed into growing oocytes via receptor‐mediated endocytosis for embryonic development. In this study, a Vg receptor (VgR) cDNA of the oriental fruit fly (Bactrocera dorsalis Hendel) was cloned via RT‐PCR and RACE (GenBank accession no. KR535603) and its expression analyzed. The BdVgR cDNA has a length of 6,585 bp encoding 1,923 amino acids. It has a conserved motif arrangement with other insect VgRs, and showed high identity to the B. cucurbitae VgR (91.4%). The expression of BdVgR mRNA and proteins was shown in both ovary and fat body. This is the first report on a nonovary‐specific VgR from a nonsocial insect. In ovary, the expression of BdVgR mRNA and proteins was inconsistent, with the transcription, but not protein, level high on D0. In fat body, the expression levels of BdVgR mRNA and proteins were high on days 5 and 6. The function of BdVgR in the fat body is not clear. However, it may be involved in reuptake of yolk proteins from the hemolymph as an amino acid reservoir or as autocrine regulation of yolk protein expression.
Probability Analysis of Terminal Sliding Mode Control of Second‐Order Markovian Jump Systems
Authors: Zhu Jiaming , Yu Xinghuo , Zhang Tianping , Cao Zhiqiang , Yang Yuequan , Fang Yu 
Published: August 2015

AbstractThis paper explores the probability problems on terminal sliding mode control of second‐order nonlinear continuous Markovian jump systems. An equivalent control based terminal sliding mode control scheme is proposed that can guarantee the systems' finite time mean‐square stability. By introducing a multi‐step transition conditional probability, the novel reaching and sliding probabilities are derived for the situations where the control force is not strong enough. This indicates that the reaching and sliding probabilities are both monotonically bounded non‐decreasing non‐negative piecewise right‐continuous functions of the control parameter. A numerical example is given to show the feasibility of the theoretical results.
Efficient fluorescence energy transfer system between fluorescein isothiocyanate and CdTe quantum dots for the detection of silver ions
Authors: Feng Yueshu , Liu Liwei , Hu Siyi , Zou Peng , Zhang Jiaqi , Huang Chen , Wang Yue , Wang Sihan , Zhang Xihe 
Published: August 2015

AbstractWe report a fluorescence resonance energy transfer (FRET) system in which the fluorescent donor is fluorescein isothiocyanate (FITC) dye and the fluorescent acceptor is CdTe quantum dot (QDs). Based on FRET quenching theory, we designed a method to detect the concentration of silver ions (Ag+). The results revealed a good linear trend over Ag+ concentrations in the range 0.01–8.96 nmol/L, a range that was larger than with other methods; the quenching coefficient is 0.442. The FRET mechanism and physical mechanisms responsible for dynamic quenching are also discussed. Copyright © 2015 John Wiley & Sons, Ltd.
Biological and protein‐binding studies of newly synthesized polymer–cobalt(III) complexes
Authors: Vignesh G. , Pradeep I. , Arunachalam S. , Vignesh S. , Arthur James R. , Arun R. , Premkumar K. 
Published: August 2015

AbstractThe polymer–cobalt(III) complexes, [Co(bpy)(dien)BPEI]Cl3 · 4H2O (bpy = 2,2′‐bipyridine, dien = diethylentriamine, BPEI = branched polyethyleneimine) were synthesized and characterized. The interaction of these complexes with human serum albumin (HSA) and bovine serum albumin (BSA) was investigated under physiological conditions using various physico‐chemical techniques. The results reveal that the fluorescence quenching of serum albumins by polymer–cobalt(III) complexes took place through static quenching. The binding of these complexes changed the molecular conformation of the protein considerably. The polymer–cobalt(III) complex with x = 0.365 shows antimicrobial activity against several human pathogens. This complex also induces cytotoxicity against MCF‐7 through apoptotic induction. However, further studies are needed to decipher the molecular mode of action of polymer–cobalt(III) complex and for its possible utilization in anticancer therapy. Copyright © 2015 John Wiley & Sons, Ltd.
A new silver nanochain SERS analytical platform to detect trace hexametaphosphate with a rhodamine S molecular probe
Authors: Shang Guangyun , Li Chongning , Wen Guiqing , Zhang Xinghui , Liang Aihui , Jiang Zhiliang 
Published: August 2015

AbstractUsing AgNO3as the precursor, stable silver nanochain (AgNC) sols, orange‐red in color, were prepared using hydrazine hydrate. A strong surface plasmon resonance Rayleigh scattering (RRS) peak occurred at 420 nm plus two surface plasmon resonance (SPR) absorption peaks at 410 nm and 510 nm. Rhodamine S (RhS) cationic dye was absorbed on the as‐prepared AgNC substrate to obtain a RhS–AgNC surface‐enhanced Raman scattering (SERS) nanoprobe that exhibited a strong SERS peak at 1506 cm–1and a strong RRS peak at 375 nm. Upon addition of the analyte sodium hexametaphosphate (HP), it reacted with RhS, which resulted in a decrease in the SERS and RRS peaks that was studied in detail. The decreased SERS and RRS intensities correlated linearly with HP concentration in the range of 0.0125–0.3 µmol/L and 0.05–1.0 µmol/L, with a detection limit of 6 nmol/L and 20 nmol/L HP respectively. Due to advantages of high sensitivity, good selectivity and simple operation, the RhS molecular probes were used to determine HP concentration in real samples. Copyright © 2015 John Wiley & Sons, Ltd.
President's page
Authors: Hirsh Sandy 
Published: August 2015

EDITOR'S SUMMARYIn addition to ongoing work on the strategic planning initiative, an important focus for the Association has been outreach to a wider audience of information industry professionals, academics and institutions around the world. The goal of the Information Professionals Task Force is to broaden the Association's scope to include practitioners in related professions, industry employers and the general public interested in information. A demonstration website is under construction with targeted content, job descriptions and links to collaborating organizations, with survey input from members in other information organizations. The International Relations Committee is tasked with promoting ASIS&T recruitment and retention of members beyond North America. Personal stories from international members, international student feedback on website development and membership dues awards will raise awareness of the benefits of Association membership for this audience.
RDAP15 Summit Report: Introduction
Authors: Mannheimer Sara 
Published: August 2015

EDITOR'S SUMMARYThe 2015 ASIS&T Research Data Access & Preservation (RDAP) Summit presented an opportunity to explore the current state and challenges facing librarians providing research data services. From pre‐conference meetings and the opening keynote through lightning talks, posters and roundtable discussions, Summit attendees considered data education, outreach and networking and evaluation of progress, all of which are represented in the articles of this special section. Keynote speaker Claudia Neuhauser spoke of the need for interdisciplinary collaboration in research data services, equally challenging for big data and small. Special attention was paid to curating student research data and specialized documentation. A special panel examined the mandate in the Office of Science and Technology Policy (OSTP) memo and responses to it.
Building Outreach on Assessment: Researcher Compliance with Journal Policies for Data Sharing
Authors: Fear Kathleen 
Published: August 2015

EDITOR'S SUMMARYDiscouraged by researchers’ low response to informational offerings on data sharing, librarians at the University of Rochester's River Campus Libraries refined their outreach strategies. To understand the support that faculty members may need, they checked the data sharing policies of journals that faculty members publish in and the level of compliance. A review of journal policies and evidence of data sharing showed both requirements and compliance varied widely. The university librarians plan to offer workshops specifically on data sharing requirements for PLOS One, the journal researchers published in most in 2014. Researchers with strong data sharing practices will be encouraged to mentor colleagues. Ongoing compliance assessment will point out where further library support may be effective.
DLF E‐Research Network Members Attend 2015 RDAP Summit
Authors: Clement Gail , Van Duinen Rita 
Published: August 2015

EDITOR'S SUMMARYThe DLF E‐Research Network, created in 2014, brings together the Digital Library Federation (DLF) and the Council on Library and Information Resources to help academic and research libraries devise collaborative strategies for data management support practices. E‐Research Network members develop support strategies appropriate for their institutions through collaboration, resource sharing, webinars and custom consultations. One of 13 universities participating in the E‐Research Network, the California Institute of Technology has been a member of the network's 2015 cohort, engaging with the wider research data management community and considering roles, resources, storage infrastructure, data ownership, rights and management costs. The 2015 cohort met in conjunction with the RDAP Summit as a community‐building and shared‐learning experience, and in a later debriefing session they identified key themes to pursue. As an emerging community of practice the DLF anticipates working with a new cohort of institutions annually.
Everyone's Job: Making Sense of the Mess
Authors: Creekmore Laura 
Published: August 2015

EDITOR'S SUMMARYThe need for information specialists is widespread and growing, and it presented itself in discouraging clarity at a state motor vehicle office. The author's daughter was to get her driver's license, prepared with necessary paperwork and a scheduled appointment, but no preparation could contend with the disarray, lines and lack of organization, signage and information on site. Reassurance from help desk staff was false and misleading. The visit, though ultimately successful, was frustrating, full of wasted time and a stark reminder of the prevalence of bad, poorly presented or missing information without enough information specialists to fix it all. A book by Abby Covert, How to Make Sense of Any Mess, presents useful advice for information professionals facing everyday information challenges.
The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation
Authors: Waldman Abraham J. , Pechersky Yakov , Wang Peng , Wang Jennifer X. , Balskus Emily P. 
Published: August 2015

AbstractDiazo groups are found in a range of natural products that possess potent biological activities. Despite longstanding interest in these metabolites, diazo group biosynthesis is not well understood, in part because of difficulties in identifying specific genes linked to diazo formation. Here we describe the discovery of the gene cluster that produces the o‐diazoquinone natural product cremeomycin and its heterologous expression in Streptomyces lividans. We used stable isotope feeding experiments and in vitro characterization of biosynthetic enzymes to decipher the order of events in this pathway and establish that diazo construction involves late‐stage N−N bond formation. This work represents the first successful production of a diazo‐containing metabolite in a heterologous host, experimentally linking a set of genes with diazo formation.
The parameter domain of convective instability of the adiabatic packed‐bed reactor
Authors: Yakhnin Vladimir , Rattanayotsakun Sorathep , Jaree Attasak , Menzinger Michael 
Published: August 2015

AbstractPacked‐bed reactors (PBR) can exhibit two types of convective instability: dynamic or differential‐flow instability (DIFI), and static instability, commonly referred to as parametric sensitivity (PS). DIFI and PS both amplify external perturbations and may result in reactor temperature excursions that can damage the product and the reactor itself. The convective character of DIFI and PS manifests itself physically in the return of the reactor to its initial stationary state after the external perturbation subsides. In this paper we describe a method of mapping the convective instability domain in the parameter space of a PBR and illustrate its application using a simple reactor model involving the standard exothermic reaction A → B + heat.
Numerical simulation of gas‐solid heat transfer behaviour in rectangular spouted bed
Authors: Wang Chunhua , Zhong Zhaoping , Wang Xiaoyi , Alting Siti Aisyah 
Published: August 2015

AbstractIn order to investigate heat transfer behaviour at an individual particle scale, the particle cooling process in a rectangular spouted bed is simulated by the Computational Fluid Dynamics‐Discrete Element Method (CFD‐DEM). As the inlet gas velocity increases, the gas‐particle convective heat transfer in the jet region is intensified, while the convective heat transfer in the annular region is weakened. The inlet gas velocity also has an influence on the particle‐particle conductive heat transfer. Particle‐particle conductive heat transfer in the jet and fountain regions can both be enhanced by increasing inlet gas velocity, but this variation trend is opposite in the annular region. Additionally, the temperature distributions of particle and gas phases in the bed are also analyzed in detail. Compared with the infrared thermography experiment, the particle cooling process in the simulation results agrees closely with that in the experimental results.
High incidence of germline BRCA mutation in patients with ER low‐positive/PR low‐positive/HER‐2 neu negative tumors
Authors: Sanford Rachel A. , Song Juhee , Gutierrez‐Barrera Angelica M. , Profato Jessica , Woodson Ashley , Litton Jennifer Keating , Bedrosian Isabelle , Albarracin Constance T. , Valero Vicente , Arun Banu 
Published: August 2015

BACKGROUNDThe 2015 National Comprehensive Cancer Network guidelines recommend that genetic counseling and germline BRCA mutation testing be offered to women under age 60 with triple‐negative breast cancer (TNBC). As a result of the 2010 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines for breast cancer, patients with breast cancers that are estrogen receptor (ER) or progesterone receptor (PR) low‐positive (1%‐9% on immunohistochemistry) are no longer strictly considered to have TNBC and may not be referred for genetic counseling. However, the incidence of BRCA mutation in patients with hormone receptor (HR) low‐positive breast cancers remains unknown, and current ASCO/CAP guidelines may result in undertesting for BRCA mutations.METHODSA prospectively maintained research database of breast cancer patients evaluated at The University of Texas MD Anderson Cancer Center between 2004 and 2014 was reviewed; 314 patients were identified with HER2/neu–negative breast cancers expressing ER and PR <10% with known BRCA mutation status.RESULTSThree hundred fourteen patients had breast cancers expressing ER and PR <10%; 238 (75.8%) had HR‐negative cancers (<1% ER and PR), and 76 (24.2%) had HR–low‐positive cancers (1%‐9% ER and/or PR). Among patients with HR‐negative tumors, 86 of 238 (36.1%) had a BRCA1/2 mutation, whereas in the HR–low‐positive group, 30 of 76 (39.5%) had a BRCA1/2 mutation. In multivariate analysis, HR status (<1% vs 1%‐9%) was not significantly associated with BRCA1/2 mutations.CONCLUSIONSThe incidence of BRCA1/2 mutations is similar in patients with HR–low‐positive breast cancer and patients with HR‐negative breast cancer. Genetic counseling and BRCA testing should be offered to patients under age 60 who have HR–low‐positive breast cancers. Cancer 2015;121:3435–43. © 2015 American Cancer Society.
Assessment of long‐term outcomes associated with urinary prostate cancer antigen 3 and TMPRSS2:ERG gene fusion at repeat biopsy
Authors: Merdan Selin , Tomlins Scott A. , Barnett Christine L. , Morgan Todd M. , Montie James E. , Wei John T. , Denton Brian T. 
Published: August 2015

BACKGROUNDIn men with clinically localized prostate cancer who have undergone at least 1 previous negative biopsy and have elevated serum prostate‐specific antigen (PSA) levels, long‐term health outcomes associated with the assessment of urinary prostate cancer antigen 3 (PCA3) and the transmembrane protease, serine 2 (TMPRSS2):v‐ets erythroblastosis virus E26 oncogene homolog (avian) (ERG) gene fusion (T2:ERG) have not been investigated previously in relation to the decision to recommend a repeat biopsy.METHODSThe authors performed a decision analysis using a decision tree for men with elevated PSA levels. The probability of cancer was estimated using the Prostate Cancer Prevention Trial Risk Calculator (version 2.0). The use of PSA alone was compared with the use of PCA3 and T2:ERG scores, with each evaluated independently, in combination with PSA to trigger a repeat biopsy. When PCA3 and T2:ERG score evaluations were used, predefined thresholds were established to determine whether the patient should undergo a repeat biopsy. Biopsy outcomes were defined as either positive (with a Gleason score of <7, 7, or >7) or negative. Probabilities and estimates of 10‐year overall survival and 15‐year cancer‐specific survival were derived from previous studies and a literature review. Outcomes were defined as age‐dependent and Gleason score‐dependent 10‐year overall and 15‐year cancer‐specific survival rates and the percentage of biopsies avoided.RESULTSIncorporating the PCA3 score (biopsy threshold, 25; generated based on the urine PCA3 level normalized to the amount of PSA messenger RNA) or the T2:ERG score (biopsy threshold, 10; based on the urine T2:ERG level normalized to the amount of PSA messenger RNA) into the decision to recommend repeat biopsy would have avoided 55.4% or 64.7% of repeat biopsies for the base‐case patient, respectively, and changes in the 10‐year survival rate were only 0.93% or 1.41%, respectively. Multi‐way sensitivity analyses suggested that these results were robust with respect to the model parameters.CONCLUSIONSThe use of PCA3 or T2:ERG testing for repeat biopsy decisions can substantially reduce the number of biopsies without significantly affecting 10‐year survival. Cancer 2015;121:4071–4079. © 2015 American Cancer Society.