bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relative responsiveness of patient-rated outcome measures in evaluating clinical change after Dupuytren's surgery: A literature review and prospective observational pilot study
Authors: Larson Debbie 
Published: October 2012

Introduction Patient-rated outcome measures (PROMs) to measure upper limb activity and participation exist but there is little evidence to support their responsiveness in Dupuytren's surgery. Methods A literature review was conducted to evaluate the relative responsiveness of PROMs used in patients treated surgically for Dupuytren's contracture. A prospective observational pilot study was performed to test feasibility and clarify procedures in advance of a larger study to compare the relative responsiveness of different PROMs. The Quick Disabilities of the Arm, Shoulder and Hand ( QuickDASH), the Patient Outcomes of Surgery-Hand/Arm (POS-Hand/Arm) and the Patient Evaluation Measure (PEM) were administered to eight patients before and 12 weeks after a fasciectomy. Results The literature review identified seven studies using PROMs before and after surgery for a Dupuytren's contracture. The PROMs were the Michigan Hand Questionnaire (MHQ), the DASH and the QuickDASH. All three had moderate-to-large effect sizes and standardized response means with the MHQ showing higher responsiveness than the DASH. In the pilot study the PEM demonstrated a higher responsiveness than the POS-Hand/Arm followed by the QuickDASH. No evidence was found to support responsiveness in terms of what is clinically relevant in relation to a patient-rated external criterion. Discussion The literature review and pilot study findings justify the need and feasibility to conduct a larger study to investigate the relative responsiveness of PROMs in patients undergoing Dupuytren's surgery.
Evaluation of outcomes for patients attending a rehabilitation group after complex hand injury
Authors: Adams Zoë , Newington Lisa , Blakeway Megan 
Published: October 2012

Introduction A rehabilitation group intervention has been an established treatment programme for patients with complex hand injuries requiring intensive therapy input. Methods A prospective audit of 20 patients was carried out to evaluate the outcomes of those attending the group with regard to improving hand function. The Disabilities of the Arm, Shoulder and Hand assessment was employed as a before and after measure of outcome. Results Nineteen out of 20 patients demonstrated an improvement in their hand function following group intervention. Patients with injuries uncomplicated by complex regional pain syndrome (CRPS) demonstrated the highest level of improvement. Patients with CRPS demonstrated the lowest level of improvement. Discussion Group therapy programmes are a valuable tool in delivering intensive therapy intervention to patients with complex hand injuries. Patients with injuries complicated by CRPS may benefit more from individualized therapy intervention.
Pilot randomized controlled trial comparing specific dynamic stability exercises with general exercises for thumb carpometacarpal joint osteoarthritis
Authors: Davenport Barbara Jane , Jansen Victoria , Yeandle Naomi 
Published: October 2012

Introduction Exercises are widely used and recommended for peripheral joint and hand osteoarthritis (OA); however, the evidence on which specific exercise regimen is most effective is unclear. Methods A pilot randomized controlled trial was conducted to compare the effect of specific first carpometacarpal (CMC) joint stabilizing exercises and general exercise on function, pain and strength. Thirty-nine participants with OA of the first CMC joint were recruited and randomly assigned into one of two exercise groups. Exercises were taught as a home programme then reviewed and only progressed as tolerated. The participant and assessing physiotherapist were blinded. Primary outcome was the Disabilities of the Arm, Shoulder and Hand (DASH) Questionnaire at three and six months. Pinch and grip strength, pain scores at rest and during pinch and abductor pollicis longus (APL) moment were secondary measures. Results Twenty-two patients completed follow-up at six months. At baseline the general exercise group had significantly stronger pinch and APL moments but was not different in any other measures. The improvement (reduction) of DASH scores at three and six months was not significantly different between the two groups; however, the general exercise group had a greater reduction in DASH score from baseline to three months (13 points P = 0.001). The outcomes were not affected ( P > 0.05) by any variables except APL moment at baseline. Increased APL moment at baseline was associated with an improved outcome in both groups ( P = 0.01). Conclusions While this pilot study was inadequately powered the results can be used to plan a future large-scale trial.
Medial meniscal root tears and meniscal extrusion transverse length ratios on MRI
Authors: Park H-J , Kim S S , Lee S-Y , Choi Y-J , Chung E-C , Rho M-H , Kwag H-J 
Published: October 2012

Objective
To evaluate the clinical utility of the meniscal extrusion transverse ratio of the medial meniscus in the diagnosis of meniscal root tear compared with the gold standard of arthroscopic diagnosis.

Methods
This retrospective study sample included 32 males and 35 females who underwent MRI at our institution. There were 24 meniscal root tear cases. The control groups were 18 cases of medial meniscal tears without root tears and 25 cases of negative meniscal findings on arthroscopy. Meniscal extrusion (L) and maximal transverse lengths (T) of the medial meniscus were measured, and L/T ratios were calculated. These results were correlated with arthroscopic findings and analysed statistically. With arthroscopic findings used as the standard of reference, the sensitivity and specificity of 10%, 11% and 12% extrusion thresholds, and 3 mm of medial meniscal extrusion (MME) as diagnostic thresholds, were calculated.

Results
The mean length of the meniscal extrusions of meniscal root tears was twice as long as the control group. The mean L/T ratio of the meniscal root tears was approximately 13%, while those of the control groups were 5%. The differences in the L and L/T between the meniscal root tears and normal and meniscal root tears and other meniscal tears were statistically significant (p&lt;0.001), but those between normal and other meniscal tears were not. The best diagnostic discrimination was achieved using an extrusion ratio threshold of 10% (79% sensitivity, 86% specificity). The 3 mm of MME threshold demonstrated high specificity (98%), but not high sensitivity (54%).

Conclusion
The mean L/T ratio of the meniscal root tears was approximately 13% and was statistically significant. The best diagnostic discrimination was achieved using an extrusion ratio threshold of 10%.

Advances in knowledge
The use of the L/T ratio in combination with MME can be a useful method for evaluating medial meniscal root tears.
Genotype Copy Number Variations using Gaussian Mixture Models: Theory and Algorithms
Authors: Lin Chang-Yun , Lo Yungtai , Ye Kenny Q. 
Published: October 2012

Abstract
Copy number variations (CNVs) are important in the disease association studies and are usually targeted by most recent microarray platforms developed for GWAS studies. However, the probes targeting the same CNV regions could vary greatly in performance, with some of the probes carrying little information more than pure noise. In this paper, we investigate how to best combine measurements of multiple probes to estimate copy numbers of individuals under the framework of Gaussian mixture model (GMM). First we show that under two regularity conditions and assume all the parameters except the mixing proportions are known, optimal weights can be obtained so that the univariate GMM based on the weighted average gives the exactly the same classification as the multivariate GMM does. We then developed an algorithm that iteratively estimates the parameters and obtains the optimal weights, and uses them for classification. The algorithm performs well on simulation data and two sets of real data, which shows clear advantage over classification based on the equal weighted average.
Comparative Evaluation of m-level Thyristor based MLCR CSC
Authors: Das Bhaba , Watson Neville , Liu Yonghe 
Published: October 2012

Abstract
In this paper a comparative evaluation study is carried out for a 3-level, 5-level, 7-level thyristor based multi-level current reinjection (MLCR)current source converters (CSC) in terms of line current total harmonic distortion (THD) obtained, reinjection transformer requirements, reinjection switch ratings, reinjection control circuitry complexities. MLCR concept adds self commutation capability to thyristors, produces high quality line current waveforms and provides reactive power compensation in CSCs. Multi-level conversion is applied to generate the required optimum injection current which, when reinjected to the ac side reduces the line current THD. Extensive PSCAD/EMTDC simulations are presented for the comparing the different m-level reinjection schemes.
Gingival Biotype Enhancement and Root Coverage Using Human Placental Chorion Membrane
Authors: Suresh D.K. , Gupta Akanksha 
Published: October 2012

Introduction: Various surgical techniques have been proposed to cover denuded root surfaces, but, the qualitative parameters of gingiva, such as gingival biotype, have been overlooked. Very few attempts have been made to convert gingival biotype to a more favorable one. This case report shows the potential of human placental chorion membrane for root coverage and enhancement of gingival biotype. The rationale behind its use was based on the membrane's properties.Case Presentation: A 56‐year‐old male with a vertical recession depth of 2 mm in the maxillary right canine was treated with coronally advanced flap along with placement of chorion membrane. Before treatment, the soft‐tissue biotype examined through transgingival probing was thin. Three months after surgery, there was 100% root coverage, and the soft‐tissue biotype also changed from thin to thick.Conclusion: Chorion membrane, which is a rich source of various collagen and non‐collagen proteins, such as laminin, fibronectin, and proteoglycans, can be used for root coverage and enhancement of thin gingival biotype to thick biotype.
A 42‐Year Observation of Traditional Periodontal Therapy Supplemented by Dental Implants
Authors: Nevins Myron , Dornbush Jeffrey , Koo Samuel , Depaoli Massimo , Kim David M. 
Published: October 2012

Introduction: Periodontal disease can be successfully treated and maintained for an extensive period. A small category of patients demonstrates aggressive periodontitis (previously known as refractory periodontitis), which does not respond appropriately to the traditional therapy even when the patient's compliance is excellent.Case Presentation: This case report presents a long‐term observation of dental implants replacing teeth with a compromised maxillary periodontium. Implants were placed initially in 1989 and 1993 to supplement some remaining teeth. These implants continue to function after 23 years. The maxillary central incisors were fractured in 2005 and replaced with two platform‐switched implants. This area has demonstrated crestal stability after 7 years.Conclusion: A long‐term observation of this patient demonstrated that dental implants are successful in periodontally compromised patients, and the crestal bone remained stable around the platform‐switched implants.
Hyaluronic Acid as an Adjunct After Scaling and Root Planing: A Prospective Randomized Clinical Trial
Authors: Eick Sigrun , Renatus Antonio , Heinicke Melanie , Pfister Wolfgang , Stratul Stefan‐Ioan , Jentsch Holger 
Published: October 2012

Background: The study is designed to determine the effect on clinical variables, subgingival bacteria, and local immune response brought about by application of hyaluronan‐containing gels in early wound healing after scaling and root planing (SRP).Methods: In this randomized clinical study, data from 34 individuals with chronic periodontitis were evaluated after full‐mouth SRP. In the test group (n = 17), hyaluronan gels in two molecular weights were additionally applied during the first 2 weeks after SRP. The control group (n = 17) was treated with SRP only. Probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and after 3 and 6 months, and subgingival plaque and sulcus fluid samples were taken for microbiologic and biochemical analysis.Results: In both groups, PD and CAL were significantly reduced (P <0.001). The changes in PD and the reduction of the number of pockets with PD ≥5 mm were significantly higher in the test group after 3 (P = 0.014 and 0.021) and 6 (P = 0.046 and 0.045) months. Six months after SRP, the counts of Treponema denticola were significantly reduced in both groups (both P = 0.043), as were those of Campylobacter rectus in the test group only (P = 0.028). Prevotella intermedia and Porphyromonas gingivalis increased in the control group.Conclusion: The adjunctive application of hyaluronan may have positive effects on PD reduction and may prevent recolonization by periodontopathogens.
Efficacy of Acellular Dermal Matrix and Coronally Advanced Flaps for the Treatment of Induced Gingival Recession Defects: A Histomorphometric Study in Dogs
Authors: Al‐Hezaimi Khalid , Rudek Ivan , Al‐Hamdan Khalid Saleh , Javed Fawad , Iezzi Giovanna , Piattelli Adriano , Wang Hom‐Lay 
Published: October 2012

Background: Gingival recession (GR) defects can be treated by various methods, including acellular dermal matrix (ADM) or coronally advanced flaps (CAFs). The aim of this histomorphometric experiment is to compare the efficacy of ADM and CAF for treating GR defects in dogs.Methods: In eight beagle dogs, a critical‐size labial GR defect was surgically induced on bilateral maxillary cuspids under general anesthesia. Test sites received ADM and CAF, and control sites underwent CAF treatment alone. Plaque index (PI), bleeding index (BI), and gingival index (GI) were measured at 4 weeks (baseline), 8 weeks, and 16 weeks. Width of keratinized gingiva (KG) was determined at baseline and at 16 weeks. Depth of recession and width of GR below the cemento‐enamel junction (CEJ) was also determined. After 4 months, animals were sacrificed, and jaw blocks were histomorphometrically assessed for tissue thickness and distance from the stent to the gingival margin (GM) and to the CEJ.Results: At 4‐, 8‐, and 16‐week intervals, there was no significant difference in the BI, GI, and PI at the test and control sites. At 16 weeks, thickness of KG was significantly higher at the control sites than test sites (P <0.01). There was no difference in the midfacial recession depth and recession width at the test and control sites at baseline and before euthanasia (16 weeks). Histomorphometrically, there was no significant difference in tissue thicknesses and distances from the stent to the GM and CEJ in the test and control sites.Conclusion: ADM might yield similar results to a CAF alone and could decrease the amount of KG.
Periodontal Inflammatory Conditions Among Gutka Chewers and Non‐chewers With and Without Prediabetes
Authors: Javed Fawad , Tenenbaum Howard C. , Nogueira‐Filho Getulio , Nooh Nasser , O'Bello Correa Fernanda , Warnakulasuriya Saman , Dasanayake Ananda P. , Al‐Hezaimi Khalid 
Published: October 2012

Background: It is known that gutka chewing jeopardizes periodontal health; however, severity of periodontal inflammation in gutka chewers with and without prediabetes remains unknown. The aim of this study is to investigate the association of periodontal inflammatory conditions with gutka chewing and prediabetes.Methods: In this cross‐sectional study, the effect of gutka use on periodontal health is investigated among 44 individuals with prediabetes and 44 without prediabetes. Demographic information regarding age, sex, duration of prediabetes, and gutka‐chewing habits was collected using a questionnaire. Periodontal inflammatory conditions (plaque index [PI], bleeding on probing [BOP], probing depth [PD], marginal bone loss [MBL]) and fasting blood glucose levels (FBGLs) were recorded. Group differences in periodontal inflammatory parameters were tested using univariate and multivariable analyses (α ≤5%).Results: Periodontal inflammatory parameters (PI, BOP, and PD) were significantly higher in individuals with prediabetes irrespective of gutka‐chewing habit (P <0.05). Odds of periodontal inflammation in individuals with prediabetes were nine times higher than in healthy controls (95% confidence interval [CI] = 3.4 to 23.6). Gutka chewing alone, chewing among individuals with prediabetes, and chewing among healthy controls did not significantly increase the odds of periodontal inflammatory conditions. Individuals with prediabetes were significantly more likely to have periodontal inflammation than individuals without prediabetes even after controlling for sex and gutka chewing (odds ratio = 13.2; 95% CI = 4.3 to 40.7).Conclusion: In medically healthy individuals, periodontal inflammatory conditions are worse in gutka chewers compared to non‐chewers; in patients with prediabetes, the severity of periodontal inflammation is governed by hyperglycemia when compared to habitual gutka usage.
Evaluating the Effect of Abnormal Audit Fees on Future Restatements
Authors: Blankley Alan I. , Hurtt David N. , MacGregor Jason E. 
Published: October 2012

SUMMARY
This article summarizes our recently published article, “Abnormal Audit Fees and Restatements” (Blankley et al. 2012), which discusses the relationship between abnormal audit fees and future restatements. We find that there is a negative relationship between the two; specifically, unusually low audit fees are associated with an increased likelihood of a future restatement (i.e., one or two years in the future). This relationship has important implications for auditors in terms of audit planning, pricing, and client retention. After summarizing the published study, we discuss how examining abnormal audit fees may be useful for audit professionals and audit committees.
Evaluating Dentin Surface Treatments for Resin-Modified Glass Ionomer Restorative Materials
Authors: Imbery TA , Namboodiri A , Duncan A , Amos R , Best AM , Moon PC 
Published: October 2012

SUMMARY
This in vitro study evaluated the effect of six surface treatments on the shear bond strength of three resin-modified glass ionomers (RMGIs) to dentin. Occlusal surfaces of caries-free third molars were reduced to expose only dentin. Surface treatments were smear layer intact (negative control), Cavity Conditioner, EDTA, Ketac Primer, Self Conditioner, and etching with 35% phosphoric acid followed by the application of Optibond Solo Plus. Filtek Z250 composite resin bonded with Optibond Solo Plus served as a positive control. Conditioning agents were used according to the manufacturers' instructions. After surface treatments, Fuji II LC, Riva LC, Ketac Nano, and Filtek Z250 were placed in copper-band matrices 5 mm in diameter and 2 mm in height and were light-cured for 20 seconds. Specimens were stored in 100% humidity for 24 hours, after which they were placed in deionized water for 24 hours at 37°C. They were then tested under shear forces in an Instron Universal Testing Machine at a crosshead speed of 0.5 mm/min. A two-way analysis of variance and Tukey honestly significant difference statistical analyses (p&lt;0.05) indicated significant interaction between RMGIs and conditioning agents. Acid etching followed by Optibond Solo Plus provided highest bond strengths for all three RMGIs, which were not statistically different from the positive control.
A Sport Physiotherapist as Medical Director: Taking a Leadership Role
Authors: Lifshitz Liran 
Published: October 2012

According to Wikipedia, a medical director is typically a physician who provides healthcare guidance, leadership, oversight, and quality assurance. The medical director is responsible for creating treatment protocols and providing oversight for all constituents who deliver healthcare services to a particular target population. There are, however, significant variations from country to country regarding the role and responsibilities of the medical director. The author discusses his experience as a sports physiotherapist in the medical director position for the Israel Football Association. J Orthop Sports Phys Ther 2012;42(9):748–749. doi:10.2519/jospt.2012.0110
IFOMPT 2012: A Rendez-Vous of Hands and Minds, September 30–October 5, 2012, Québec City, Canada
Authors: Werstine Rob , Chesworth Bert M. 
Published: October 2012

Since its founding in Montreal, Canada in 1974, the International Federation of Orthopaedic Manipulative Physical Therapists (IFOMPT) has been providing orthopaedic and manual therapists from around the world with the highest-quality learning opportunities through a conference held every 4 years. In 2012, IFOMPT is partnering with The International Private Practitioners Association (IPPA) to host this prestigious event in Quebec City, Canada. As more than 51% of the Canadian Physiotherapy Association membership is working in private practice, this adds even greater value to this quadrennial event. This conference emulates best-evidence practice in the marriage of research and clinical excellence by pulling together some of the best and brightest hands and minds in orthopaedic physiotherapy. Through a call for proposals that equally emphasized research, clinical excellence, and the knowledge translation link between the two, the IFOMPT mandate of clinical and academic excellence has been kept at the forefront of this year's conference. Included in this supplement are the IFOMPT 2012 keynote addresses, schedule, and abstracts. J Orthop Sports Phys Ther 2012;42(10):A1–A83. doi:10.2519/jospt.2012.0302
Disruption of a Patellar Tendon Repair
Authors: Harris Kevin D. , Deyle Gail D. , Bui-Mansfield Liem T. 
Published: October 2012

The patient was a 38-year-old man evaluated by a physical therapist 14 weeks after repair of the left patellar tendon. The physical therapist requested radiographs, which revealed findings consistent with a patellar tendon retear. The radiologist recommended further evaluation with magnetic resonance imaging, which showed a left patellar tendon tear. J Orthop Sports Phys Ther 2012;42(8):738. doi:10.2519/jospt.2012.0414
T1 Radiculopathy
Authors: Willett Gilbert M. , Buresh Timothy L. 
Published: October 2012

The patient was a 40-year-old man who had experienced a constant deep ache over his left T1–2 paravertebral muscle region. Following 2 weeks of physical therapist intervention with no improvement, the patient self-referred to a neurosurgeon. Magnetic resonance imaging of the cervical and upper thoracic spine regions was ordered and revealed a left paracentral disc protrusion at T1–2 that resulted in moderate left foraminal stenosis. J Orthop Sports Phys Ther 2012;42(8):739. doi:10.2519/jospt.2012.0415