bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case of pure ovarian squamous cell carcinoma resistant to combination chemotherapy with paclitaxel and carboplatin but responsive to monotherapy with weekly irinotecan
Authors: Nakamura Yasuhiko , Kamei Toshiaki , Shinagawa Masahiro , Sakamoto Yuka , Miwa Ichiro 
Published: December 2014

AbstractPrimary ovarian squamous cell carcinoma is uncommon, and the optimal treatment strategy for this disease has not yet been established. A 71‐year‐old woman diagnosed with FIGO stage IIb pure ovarian squamous cell carcinoma underwent cytoreductive surgery followed by combination chemotherapy with paclitaxel and carboplatin. After the second treatment course, a recurrent mass grew rapidly, and serum tumor maker levels increased. Monotherapy with weekly irinotecan was then instituted. This second‐line chemotherapy was remarkably effective, and the patient subsequently underwent complete interval debulking surgery with a pathological complete response after the third treatment course. Weekly irinotecan is an effective choice for primary ovarian squamous cell carcinoma resistant to combination chemotherapy with paclitaxel and carboplatin.
Visualization of placental hypocirculation with typical patterns using conventional magnetic resonance imaging: Two case reports
Authors: Himoto Yuki , Kido Aki , Minamiguchi Sachiko , Mogami Haruta , Konishi Ikuo , Togashi Kaori 
Published: December 2014

AbstractWe report two cases of clinically suspected placental hypocirculation, as per evidenced by specific half‐Fourier acquisition single‐shot turbo spin‐echo (HASTE) magnetic resonance findings of the whole placenta. Patient 1 was a case of fetal growth restriction caused by pregnancy‐induced hypertension, while patient 2 experienced a discordant dichorionic diamniotic twin pregnancy with fetal growth restriction complication with a velamentous insertion of the umbilical cord in the smaller twin. In both cases, HASTE images showed noticeably decreased signal intensity with high‐intensity signal spots present in the central region of the placenta. In the twin pregnancy case, the low‐intensity signal area in the placenta of the smaller twin was much lower compared to that of the larger twin. Pathological findings failed to support or explain these observations. HASTE images might reflect compensatory alternation of the distribution of maternal blood and villus caused by hypocirculation. In conclusion, our results suggest that HASTE imaging might be a useful approach for the visualization of placental hypocirculation.
Prediction of perinatal outcomes based on primary symptoms in women with placental abruption
Authors: Kasai Michi , Aoki Shigeru , Ogawa Miyuki , Kurasawa Kentaro , Takahashi Tsuneo , Hirahara Fumiki 
Published: December 2014

AbstractAimsPlacental abruption is an important cause of perinatal mortality and morbidity. Although there are many reports on the risk factors for placental abruption, there are few on its classification. Our aim is to evaluate the associations between primary symptoms and the outcomes of placental abruption.Material and MethodsWe carried out a retrospective cohort study of 12 474 births at the Perinatal Center for Maternity and Neonates of the Yokohama City University Medical Center between January 2000 and December 2012. There were 151 women with placental abruption, 136 of whom were included in this study. The subjects were classified into two groups according to their primary symptoms: those with bleeding (external bleeding group) and those with abdominal pain (abdominal pain group). Maternal and neonatal outcomes were compared between the two groups.ResultsBoth fetal and maternal outcomes were significantly poorer in the abdominal pain group than in the external bleeding group in terms of intrauterine fetal death (6.5% vs 33.3%, P < 0.001), perinatal mortality (8.1% vs 33.3%, P = 0.001), umbilical arterial pH < 7.1 (15.7% vs 57.1%, P < 0.001), bleeding volume, rate of blood transfusion, and disseminated intravascular coagulation incidence.ConclusionsThis classification based on primary symptoms was found to be useful for predicting both maternal and neonatal outcomes of placental abruption.
Candida glabrata sepsis associated with chorioamnionitis in an IVF twin pregnancy: Should we deliver?
Authors: Tan Shu Qi , Ng Oon Tek , Khong Chit Chong 
Published: December 2014

AbstractWe report a case of in vitro fertilization (IVF)‐acquired Candida glabrata chorioamnionitis successfully treated through systemic maternal antifungal treatment prior to delivery. To the best of our knowledge, this is the first case of its kind in the literature. C. glabrata chorioamnionitis in pregnancy is rare, but the current literature suggests a very high fetal fatality in such cases. It is known to have an association with cervical stitch, amniocentesis, chorionic villous sampling, and assisted reproductive techniques such as IVF. Given the increasing global use of artificial reproductive techniques, it is important to raise awareness of this condition and highlight its potential complications. Early recognition of possible fetal infection could enable early initiation of systemic antifungal treatment. It would be prudent to consider early delivery once fetal maturity is achieved despite normal fetal monitoring.
Susceptibility‐Weighted Phase Imaging and Oxygen Extraction Fraction Measurement during Sedation and Sedation Recovery using 7T MRI
Authors: Goodwin Jonathan A. , Kudo Kohsuke , Shinohe Yutaka , Higuchi Satomi , Uwano Ikuko , Yamashita Fumio , Sasaki Makoto 
Published: December 2014

ABSTRACTBACKGROUND & PURPOSEIn this work, we demonstrate oxygen extraction fraction (OEF) measurement using 7T MRI with susceptibility‐weighted imaging (SWI), in sedated and nonsedated adults.METHODSTen healthy subjects (30.3 ± 4.5 years, 9 men, 1 woman) formed control (n = 5) and sedation groups (n = 5). Midazolam and propofol injection was administered to the same sedation group subjects during 2 different scanning sessions. Two‐dimensional SPGR imaging was performed before, during, and twice after (propofol, +10, +30 minutes; midazolam, +10, +40 minutes) conscious sedation. The equivalent procedure was performed with the control group without sedation. After SWI analysis, change in OEF between scans was quantified, and parcelated ΔOEF maps were generated with 77 gray matter (GM)‐containing volumes‐of‐interest (VOIs).RESULTSSignificant decreases in OEF were shown in 14 GM VOIs during sedation relative to the control group, most notably during midazolam sedation (P < .05). In contrast, no significant decrease was observed after 10 minutes and in only 4 VOIs after 40 minutes recovery.CONCLUSIONSignificant change in ΔOEF during conscious sedation using midazolam and propofol could be measured using SWI at 7T in vivo. This may be a potentially useful approach for the noninvasive assessment of OEF in the brain on a clinical basis.
Pediatric Cerebellar Tumors: Does ADC Analysis of Solid, Contrast‐Enhancing Tumor Components Correlate Better with Tumor Grade than ADC Analysis of the Entire Tumor?
Authors: Orman Gunes , Bosemani Thangamadhan , Higgins Luke , Carson Kathryn A. , Huisman Thierry A.G.M. , Poretti Andrea 
Published: December 2014

ABSTRACTBACKGROUNDApparent diffusion coefficient (ADC) values assist differentiating malignancy grades in pediatric cerebellar tumors. Previous studies reported the significance of ADC measurements within the solid, contrast‐enhancing tumor component (SCT). These measurements take into account only a part of the tumor. In this study, we compared ADC measurements of the SCT versus entire tumor (ET).METHODSADC values were measured in the SCT and ET. Absolute tumor ADC values and cerebellar and thalamic ratios were compared across tumor grades.RESULTSThirty‐two children with 16 low‐grade and 16 high‐grade tumors were included. The median age at presurgical MRI was 7.66 years (range .08‐17.38 years). In the SCT, absolute ADC values, cerebellar ratio, and thalamic ratio were higher in low‐ versus high‐grade tumors (P < .001). In the ET, absolute ADC values, cerebellar ratio, and thalamic ratio were also higher in low‐ versus high‐grade tumors (P < .005). Cut‐off absolute ADC values of .9 × 10−3 mm/s2 (sensitivity 94%, specificity 100%) and 1.5 × 10−3 mm/s2 (sensitivity 88%, specificity 75%) were calculated for measurement in the SCT and ET, respectively, to differentiate between tumors grades.CONCLUSIONA rigorous ADC measurement of the SCT has a higher sensitivity and specificity in predicting tumor grade compared to ADC measurement of the ET.
Dietary Levamisole as Immunostimulant for Striped Surubim, Pseudoplatystoma reticulatum
Authors: Zanon Ricardo Basso , da Silva Cerozi Brunno , Cyrino José Eurico Possebon , de Castro Silva Tarcila Souza 
Published: December 2014

AbstractImmunostimulants are better suited for disease control than using drugs and chemicals as remedies in animal production. This study evaluates effects of dietary levamisole on growth and immunological parameters response of Pseudoplatystoma reticulatum. A trial was set up in a completely randomized design with six treatments – 0.0, 50, 100, 200, 300, and 500 mg levamisole per kg of feed (n = 3) – fed until apparent satiation, twice a day, for 60 d to striped surubim (77.68 ± 2.5 g) randomly stocked in 18 plastic tanks (300 L; 10 fish per tank). Dietary levamisole affected lysozyme activity and concentration, the best effects were recorded for fish fed 247 mg levamisole per kg of feed, that is, levamisole positively influenced innate immune system of striped surubim. However, dietary levamisole did not affect serum protein, albumin and globulins, as well as leukocyte respiratory burst activity and leukocyte proliferation. No differences in growth parameters were recorded. Dietary levamisole improved immunological responses of striped surubim.
Sequencing chromosome 5D of Aegilops tauschii and comparison with its allopolyploid descendant bread wheat (Triticum aestivum)
Authors: Akpinar Bala A. , Lucas Stuart J. , Vrána Jan , Doležel Jaroslav , Budak Hikmet 
Published: December 2014

SummaryFlow cytometric sorting of individual chromosomes and chromosome‐based sequencing reduces the complexity of large, repetitive Triticeae genomes. We flow‐sorted chromosome 5D of Aegilops tauschii, the D genome donor of bread wheat and sequenced it by Roche 454 GS FLX platform to approximately 2.2x coverage. Repetitive sequences represent 81.09% of the survey sequences of this chromosome, and Class I retroelements are the prominent type, with a particular abundance of LTR/Gypsy superfamily. Nonrepetitive sequences were assembled to cover 17.76% of the total chromosome regions. Up to 6188 nonrepetitive gene loci were predicted to be encoded by the 5D chromosome. The numbers and chromosomal distribution patterns of tRNA genes suggest abundance in tRNALys and tRNAMet species, while the nonrepetitive assembly reveals tRNAAla species as the most abundant type. A comparative analysis of the genomic sequences of bread wheat and Aegilops chromosome 5D indicates conservation of gene content. Orthologous unique genes, matching Aegilops 5D sequences, numbered 3730 in barley, 5063 in Brachypodium, 4872 in sorghum and 4209 in rice. In this study, we provide a chromosome‐specific view into the structure and organization of the 5D chromosome of Ae. tauschii, the D genome ancestor of bread wheat. This study contributes to our understanding of the chromosome‐level evolution of the wheat genome and presents a valuable resource in wheat genomics due to the recent hybridization of Ae. tauschii genome with its tetraploid ancestor.
Neurofibromatosis Type 1 Diagnosed in a Child Based on Multiple Juvenile Xanthogranulomas and Juvenile Myelomonocytic Leukemia
Authors: Jans Sune R. R. , Schomerus Eckhard , Bygum Anette 
Published: December 2014

AbstractAn association between juvenile xanthogranuloma (JXG), neurofibromatosis type 1 (NF1), and juvenile myelomonocytic leukemia (JMML) has been described in the literature but has only been documented in approximately 20 cases. We diagnosed a patient with NF1 at 25 months of age, before any cutaneous stigmata of this disease had appeared, because we decided to screen for the NF1 gene mutation because of his presentation with multiple JXGs and moderate macrocephaly (2.5 standard deviations) at 9 months of age and JMML diagnosed at 20 months of age. The child is well today after treatment with chemotherapy and allogenic bone marrow transplantation. With increased awareness, patients with JXG and NF1 who develop symptoms possibly related to JMML, such as paleness, skin bleeding, cough, unexplained fever, and hepatosplenomegaly, should be further evaluated. We also emphasize that multiple JXG lesions can be an early marker of NF1.
Linear Cutaneous Lupus Erythematosus with Calcinosis Cutis and Milia
Authors: Ma Han , Liao Mengsi , Qiu Shu , Lu Rongbiao , Lu Chun 
Published: December 2014

AbstractLinear cutaneous lupus erythematosus (LCLE) is an unusual manifestation of cutaneous lupus erythematosus in which erythematous, atrophic, dyschromic lesions are located along the lines of Blaschko. Calcinosis cutis and secondary milia are very uncommon in lupus erythematosus. We present a rare case of LCLE with calcinosis cutis and milia.
Positive appraisal of in‐home family caregivers of dementia patients as an influence on the continuation of caregiving
Authors: Kajiwara Kohei , Nakatani Hisae , Ono Mitsu , Miyakoshi Yukiko 
Published: December 2014

AbstractBackgroundWe attempted to determine the factors that influence the continuation of in‐home caregiving for patients with dementia.MethodsThe participants were family caregivers of dementia patients who received home care services. Data were collected via a questionnaire completed by caregivers and then returned in the mail. Of the 705 caregivers who received the questionnaire, 405 completed and returned it (response rate: 57.4%).ResultsThe average age of the caregivers was 63.9 ± 11.5 years, and they had been providing care for an average of 5.1 ± 4.1 years. The average age of the patients was 84.7 ± 7.4 years. We analyzed the path model. Caregivers’ current feelings about continuing caregiving were directly affected by a positive appraisal of caregiving (β = 0.20, P < 0.001) and by the burden they experienced (β = −0.39, P < 0.001). The continuation of caregiving of patients with worsening symptoms was directly affected by a positive appraisal of caregiving (β = 0.15, P < 0.01) and by the burden experienced by the caregivers (β = −0.46, P < 0.001). The continuation of caregiving was indirectly affected by the patients’ cognitive impairment and by the behavioral and psychological symptoms of dementia score.ConclusionsThe continuation of in‐home caregiving among caregivers of patients with dementia was affected by both positive appraisal and caregiver burden. In addition, the present study revealed that behavioral and psychological symptoms of dementia score indirectly affects the continuation of caregiving by directly affecting caregiver burden.
Optimum Sensor Placement for Impact Location Using Trilateration
Authors: De Stefano M. , Gherlone M. , Mattone M. , Di Sciuva M. , Worden K. 
Published: December 2014

AbstractA key problem associated with structural health monitoring (SHM) is the placement of sensors upon a structure to detect the existence, location, and the extent of any damage. Because input data coming from the sensors are groups of measurements, it is arguable that the most widely used approach to SHM nowadays is to consider it as a statistical pattern recognition problem. Artificial neural networks have made a great impact on pattern recognition practice. A problem associated with this monitoring strategy is to find a good compromise between the quality of information achieved by the sensor network, increasing with the sensor density, and the need to keep the minimum weight and instrumentation cost. Thus, the number of sensors must be kept under control, and a search of the optimal location of such sensors needs to be performed.All these aspects have been taken into account in the present work, dealing with the problem of optimum sensor placement for impact location on a multilayered composite structure.Multilayered composite structures may suffer particularly relevant trauma when subject to low‐velocity impacts, as they may produce non‐visible or barely visible damage on the structure surface, while remarkable subsurface delaminations may be present. Such hidden damage, when remaining undetected, may grow to catastrophic failure. To overcome this issue, a neural network approach has been used here to predict the impact locations on a composite panel from time‐dependent data recorded on a set of surface‐mounted piezoelectric sensors during an experimental impact test. A genetic algorithm has been used to find the optimal sensor layout that minimised the error in predicting the impact location. A new approach, based on trilateration, is discussed and compared with the traditional one and is shown to provide the same degree of accuracy at reduced computational cost.
THE NORMAL INTERPHASE IN THE POLYURIA WHICH FOLLOWS SECTION OF THE SUPRAOPTICO‐HYPOPHYSIAL TRACTS IN THE DOG
Authors: O'Connor W. J. 
Published: December 2014

1. Four facts have been established concerning the period from the 6th to 11th days following section of the supraoptico‐hypophysial tracts in the dog: (a) The daily urine volume is low (the “normal interphase” of Fisher, Ingram and Ranson [1938] between the temporary and permanent polyurias). (b) There is no diuretic response to administered water. Neither (a) nor (b) occurs following operative removal of the posterior lobe of the pituitary. (c) Sodium chloride administered by stomach tube in isotonic solution is excreted freely but in a small volume of urine of high chloride concentration. (d) Antidiuretic activity is present in the urine.2. These facts indicate, and are adequately explained by, the conclusion that during the 6th‐llth days after section of the tracts active material escapes from the degenerating pars nervosa of the pituitary into the blood stream at rates up to 0·3 mU per min.
CORTICAL ISCHÆMIA OF THE KIDNEY WITH MAINTAINED BLOOD FLOW THROUGH THE MEDULLA
Authors: Daniel P. M. , Peabody C. N. , Prichard Marjorie M. L. 
Published: December 2014

1. Further studies of the renal circulation have been carried out by means of rapid serial angiography. The kidney was exteriorized so that the intrarenal circulation could be demonstrated in greater detail.2. The investigation has shown that an ischæmia of the cortex of the kidney with a maintained circulation through the medulla may occur in the cat, dog, sheep and monkey, as well as in the rabbit.3. The view is stressed that in normal animals blood passing through either the cortex or the medulla all passes through glomeruli.4. The condition of cortical necrosis of the kidney is adduced as evidence that cortical ischæmia with maintained medullary blood flow occurs in man.
THE EFFECT OF B1‐PYRIMIDINE ON GASTRIC SECRETION
Authors: Sircus W. 
Published: December 2014

1. In dogs with gastric pouches and in decerebrate or anæsthetised cats, gastric secretion was stimulated by a variety of methods. These included injection of insulin, carbachol, ethanol, histamine, feeding, and vagal stimulation.2. An intravenous dose of 50 mg. per kilo of 2‐methyl‐5‐amino‐methyl‐6‐amino‐pyrimidine (B1‐pyrimidine) produced a transient but considerable increase in the volume‐rate of the gastric secretion so formed, but was usually without significant effect on the acidity of the juice.3. The drug did not itself stimulate gastric secretion at this dose.4. The results are considered to support the theory that histamine is involved in the response of the parietal cell to all types of stimuli.
A QUANTITATIVE METHOD FOR MEASURING RED CELL CONTENT OF TISSUES IN VIVO
Authors: Delorme E. J. 
Published: December 2014

1. Average in vivo values for red cell allocation in liver, spleen, kidney, gut and muscle in dogs have been obtained by an appropriate red cell labelling technique and expressed in numbers of red blood corpuscles per cubic millimetre of tissue.2. The changes in red cell content observed in these tissues when the animal is bled are discussed and the importance of gradual red cell accumulation in muscle is pointed out. When blood is re‐infused after a prolonged period of oligæmia, general engorgement is noted in all tissues studied, with the exception of the spleen which remains relatively ischæmic.3. When specific areas of contralateral frontal cortex are stimulated in the monkey, rapid but transitory increases in red cell content of muscle occur.
THE PITUITARY GLAND AND THE VASCULAR TONE OF THE KIDNEY
Authors: Brull L. , Louis-Bar D. 
Published: December 2014

In 7 out of 8 experiments in which the pituitary body had been removed for two or more hours, the renal blood flow increased in parallel with large increases of blood pressure.This and previous work suggests that after hypophysectomy there is an alteration of the response of kidneys to pressure in dogs, and that the pituitary body contributes a vasoconstrictor principle to the blood.
THE EFFECTS OF l‐ADRENALINE AND dl‐NORADRENALINE ON THE MEAN RIGHT ATRIAL PRESSURE OF SHEEP WITH INTACT CIRCULATIONS, AND ON THE MEAN INFERIOR VENA CAVAL PRESSURE OF ARTIFICIALLY PERFUSED SHEEP
Authors: Tyrer J. H. 
Published: December 2014

1. The effects of l‐adrenaline and dl‐noradrenaline upon systemic venous pressure were examined in sheep with intact circulations and in sheep whose pulmonary and systemic circulations were artificially perfused at constant rates.2. Both substances caused a rise of systemic venous pressure in intact and perfused sheep. The latter preparation excluded cardiac factors, which have been considered by some authors to be the main cause of the pressure rise in intact animals after adrenaline, and permitted some analysis of the possible mechanisms.3. In the majority of experiments, both in intact and perfused sheep, l‐adrenaline and dl‐noradrenaline caused an initial transitory fall of systemic venous pressure before the rise. This fall has been described only once previously and attributed to an initial transitory cardiac stimulation. The present studies permit analysis of the fall, which is readily obtained in perfused sheep, where cardiac effects can be excluded.
THE EFFECT OF REMOVAL OF THE ADRENAL MEDULLA ON THE CHANGES IN OXYGEN CONSUMPTION AND RADIO‐IODINE (I131) UPTAKE FOLLOWING EXPOSURE TO COLD IN ALBINO RATS
Authors: Beattie J. , Chambers R. D. 
Published: December 2014

1. The rises in oxygen consumption of rats and in the radio‐iodine uptake by their thyroid glands which occur when the environmental temperature is lowered are in no way diminished after the adrenal medulla is extirpated.2. Extirpation of the adrenal medulla is not followed by a fall in body temperature either under an environmental temperature of 29·5o° C. or after exposure to an environmental temperature of 18o° C.3. The rise in radio‐iodine uptake on exposure to cold appears to be due to some mechanism independent of the balance between thyroxine and thyrotrophic hormone concentrations in the blood.
CHANGES IN OXYGEN CONSUMPTION, RADIO‐IODINE UPTAKE AND BODY TEMPERATURE FOLLOWING EXPOSURE TO COLD IN ALBINO RATS WITH HYPOTHALAMIC LESIONS
Authors: Beattie J. , Chambers R. D. 
Published: December 2014

Quart. J. exp. Physiol. 38, No. 3.J. BEATTIE AND R. D. CHAMBERS.Pp. 193‐200.For“The temperature range of the cold environment was between 17° and 22° C., with a mean temperature of 20·5° C.,”read“The temperature range of the cold environment was between 13° and 18° C., with a mean value of 16·5° C.”