bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis and Antimicrobial Elucidation of [1,2,4]‐Triazole‐3‐thione Derivatives.
Authors: Gondhani D. R. , Sanghani A. M. , Sanja D. B. , Dobariya P. B. 
Published: March 2013

AbstractSome of the newly synthesized title compounds (VII) show moderate to good antibacterial and antifungal activities.
ChemInform Abstract: An Efficient Four‐Component, One‐Pot Synthesis of 6‐Amino‐4‐aryl‐3‐methyl‐2,4‐dihydropyrano [2,3‐c]pyrazole‐5‐carbonitriles under Phase‐Transfer Catalyst.
Authors: Ablajan Keyume , Liju Wang , Tuoheti Anagu , Kelimu Yakefujiang 
Published: March 2013

AbstractThe reaction proceeds with methyl and ethyl acetoacetate, affording the target compounds with higher yields for the methyl‐derivative (I).
ChemInform Abstract: Synthesis and Characterization of 5‐(6‐Substituted phenyl‐2H‐chromen‐3‐yl) Oxazole Derivatives.
Authors: Sadanandam Palle , Sathaiah Nomula , Jyothi Vantikommu , Chari Murugalla A. , Shobha Donthabakthuni , Das Parthasarathi , Mukkanti Khagga 
Published: March 2013

AbstractA three step path is developed to prepare the target compounds, including a cyclization to construct the chromene fragment [cf.
ChemInform Abstract: A Coumarin—Meldrum′s Acid Conjugate Based Chemodosimetric Probe for Cyanide.
Authors: Li Hongda , Wen Zhi , Jin Longyi , Kan Yuhe , Yin Bingzhu 
Published: March 2013

AbstractThe probe (I) is highly reactive and selective to NaCN, with a fast response in aqueous solution.
ChemInform Abstract: Synthesis of Substituted Quinolines by Iron‐Catalyzed Oxidative Coupling Reactions.
Authors: Liu Peng , Li Yuxi , Wang Haiyu , Wang Zhiming , Hu Xianming 
Published: March 2013

AbstractA simple oxidative coupling of anilines with various aromatic terminal alkynes under conditions A) produces a broad spectrum of functionalized quinoline structures.
ChemInform Abstract: A Facile One‐Pot Synthesis of Dicycloalkenopyridines at Ambient Temperature Conditions.
Authors: Goswami Santosh V. , Thorat Prashant B. , Bhusare Sudhakar R. 
Published: March 2013

AbstractTitle compounds of type (III) are of interest as drug skeletons or chelating ligands in coordination chemistry.
ChemInform Abstract: Ruthenium‐Catalyzed Oxidative Coupling/Cyclization of Isoquinolones with Alkynes Through C—H/N—H Activation: Mechanism Study and Synthesis of Dibenzo[a,g]quinolizin‐8‐one Derivatives.
Authors: Li Bin , Feng Huiliang , Wang Nuancheng , Ma Jianfeng , Song Haibin , Xu Shansheng , Wang Baiquan 
Published: March 2013

AbstractThe mechanism of the title reaction is investigated by isolation of all relevant intermediates.
ChemInform Abstract: Novel Method of Synthesis of 2,3‐Dihydrofuro[3,2‐h]quinolines.
Authors: Osyanin V. A. , Osipov D. V. , Klimochkin Yu. N. 
Published: March 2013

Abstractvia reaction of γ‐hydroxyquinoline derivatives (I) with in situ generated pyridinium ylides
ChemInform Abstract: Simple and Efficient One‐Pot Synthesis of Imidazo[1,2‐a]pyridines Catalyzed by Magnetic Nano‐Fe3O4—KHSO4·SiO2.
Authors: Guntreddi Tirumaleswararao , Allam Bharat Kumar , Singh Krishna Nand 
Published: March 2013

AbstractA facile and straightforward synthesis of imidazopyridines (IV) and (VI) is achieved by employing the title system‐catalyzed three‐component reaction of aminopyridine (I), aliphatic and aromatic aldehydes (II) and (V), and aliphatic and aromatic alkynes (III).
ChemInform Abstract: Stereoselective and Catalytic Access to β‐Enaminones: An Entry to Pyrimidines.
Authors: Gayon Eric , Szymczyk Monika , Gerard Helene , Vrancken Emmanuel , Campagne Jean‐Marc 
Published: March 2013

AbstractTreatment of α‐arylated propargylic hydroxylamines with catalytic amounts of NaOH results in convenient and stereoselective formation of (Z)‐β‐enaminones.
ChemInform Abstract: A Facile One‐Pot Synthesis of 2‐Thioxo‐dihydropyrimidines and Polyfunctionalized Pyran Derivatives as Mimics of Novel Calcium Channel Modulators.
Authors: Yadlapalli Rama Krishna , Chourasia O. P. , Perali Ramu Sridhar 
Published: March 2013

AbstractThe condensation of dione (III) with aromatic aldehydes and either thiourea or malononitrile affords the heterocyclic title systems.
ChemInform Abstract: Synthesis and Identification of Novel Indolo[2,3‐a]pyrimido[5,4‐c]carbazoles as a New Class of Anticancer Agents.
Authors: Pierce Larry T. , Cahill Michael M. , Winfield Hannah J. , McCarthy Florence O. 
Published: March 2013

AbstractAn optimized photocyclization step leads to the novel azaindolo[2,3‐a]pyrimido[5,4‐c]carbazole (VIb) representing a new class of potential anticancer agents.
ChemInform Abstract: Condensation Reactions of 2‐Aminobenzohydrazide with Various Carbonyl Compounds.
Authors: El‐Shaieb Kamal M. , Ameen Mohamed A. , Abdel‐Latif Fathy F. , Mohamed Asmaa H. 
Published: March 2013

AbstractCondensation of benzohydrazide (I) with dimedone (II) proceeds in the presence of catalytic amounts of iodine providing spiro‐quinazoline (III) whereas, phthalazino‐quinazoline (V) is obtained by simple reaction with (IV) in glacial acetic acid.
ChemInform Abstract: An Expedient Synthesis of 5‐Substituted Imidazo[1,2‐c]quinazolines.
Authors: Korshin Edward E. , Sabirova Leila A. , Levin Yakov A. 
Published: March 2013

AbstractA practical synthesis of the title system (V), which includes 2 biologically important heterocyclic moieties, is developed.
ChemInform Abstract: Novel Transformation of α,β‐Unsaturated Aldehydes and Ketones into γ‐Amino Alcohols or 1,3‐Oxazines via a 4 or 5 Step, One‐Pot Sequence.
Authors: Calow Adam D. J. , Batsanov Andrei S. , Fernandez Elena , Sole Cristina , Whiting Andrew 
Published: March 2013

AbstractA four‐step procedure is elaborated for the preparation of γ‐amino alcohols from α,β‐unsaturated carbonyl compounds by imine formation, β‐boration, imine reduction, and oxidation of boronic ester.
ChemInform Abstract: A Novel and Convenient Method for the Synthesis of New Derivatives of Pyrido[3,2‐e]pyrrolo[1,2‐a][1,4]diazepine‐6,11‐dione.
Authors: El Bouakher Abderrahman , Prie Gildas , Aadil Mina , Lazar Said , Akssira Mohamed , Viaud‐Massuard Marie‐Claude 
Published: March 2013

AbstractA novel and efficient access to new optically active 2‐substituted pyridopyrrolodiazepine derivatives is developed involving peptide coupling of 3‐aminopyridinecarboxylic acid (I) with proline ester [→(III)] and intramolecular cyclization of corresponding brominated coupling product (IV) as the key steps.
ChemInform Abstract: Efficient Medium Ring Size Bromolactonization Using a Sulfur‐Based Zwitterionic Organocatalyst.
Authors: Cheng Yi An , Chen Tao , Tan Chong Kiat , Heng Jun Jie , Yeung Ying‐Yeung 
Published: March 2013

AbstractThe first organocatalytic halolactonization of unsaturated carboxylic acids using a zwitterion as catalyst is developed.
ChemInform Abstract: Reaction of 2‐Pyridylselenenyl Bromide with Divinyl Selenide.
Authors: Potapov V. A. , Malinovich D. A. , Amosova S. V. , Rusakov Yu. Yu. , Bhasin K. K. 
Published: March 2013

AbstractFirst time, in situ generated pyridylselenenyl bromide reacts with divinyl selenide to give vinylselanylselenazolopyridinium bromide (III) in a two‐step one‐pot procedure.
ChemInform Abstract: Unexpected Zirconium‐Mediated Multicomponent Reactions of Conjugated 1,3‐Butadiynes and Monoynes with Acyl Cyanide Derivatives.
Authors: Yu Shasha , You Xu , Liu Yuanhong 
Published: March 2013

AbstractThis method yields functionalized heterozirconacycles which can be protonolyzed to give 1,4‐benzodiazepin‐2‐ones and oxazolo[5,4‐b]pyridine derivatives.
ChemInform Abstract: Anti‐HIV Activity of Semisynthetic Derivatives of Andrographolide and Computational Study of HIV‐1 gp120 Protein Binding.
Authors: Uttekar Mayur M. , Das Tiyasa , Pawar Rohan S. , Bhandari Beena , Menon Vidya , Nutan Nutan , Gupta Satish K. , Bhat Sujata V. 
Published: March 2013

AbstractSeveral andrographolide derivatives (I) and (II) are synthesized and evaluated for their anti‐HIV activity in a cell‐free virus infectivity assay.
ChemInform Abstract: Synthesis and Antimicrobial Activity of New Phenytoin Derivatives and Their Acyclic Nucleoside Analogues.
Authors: Ali O. M. , Amer H. H. , Mosaad A. A. , Abdel‐Rahman A. A.‐H. 
Published: March 2013

AbstractMost of the newly synthesized compounds exhibit moderate to high antimicrobial activities.
ChemInform Abstract: De novo Chemoenzymatic Synthesis of Sialic Acid.
Authors: Stallforth Pierre , Matthies Stefan , Adibekian Alexander , Gillingham Dennis G. , Hilvert Donald , Seeberger Peter H. 
Published: March 2013

AbstractThe MPS‐catalyzed pyruvate addition is characterized by high diastereoselectivity and mild reaction conditions.
ChemInform Abstract: RbjMk[Fe(CN)6]l (M: Co, Ni) Prussian Blue Analogue Hollow Nanocubes: A New Example of a Multilevel Pore System.
Authors: Risset Olivia N. , Knowles Elisabeth S. , Ma Shengqian , Meisel Mark W. , Talham Daniel R. 
Published: March 2013

AbstractUniform Rb0.4M4 [Fe(CN)6]2.8·7.2H2O (M: Co, Ni) hollow nanoparticles are prepared by dissolving Rb1.6Mn4[Fe(CN)6]3.2 ·4.8H2O@Rb0.4M4 [Fe(CN)6]2.8·7.2H2 O core@shell heterostructures in water (45 °C, 45 min, 80 and 78% yield for the Co and Ni compounds, respectively).
Numerical study of counter‐current gas–solid flow in FCC disengager and stripper
Authors: Jia Dening , Zhao Hui , Berrouk Abdallah S. , Yang Chaohe , Shan Honghong 
Published: March 2013

AbstractDetailed study of the gas–solid flow in FCC reactor was performed using Euler–Euler two‐fluid model. Two distinct regions were identified in the reactor vessel based on differences in catalyst void fraction and fluid flow: the dilute phase congested disengager region and dense phase congested stripper region. Velocity profile revealed an inert yet random flow pattern in the disengager and a counter‐current type of flow with a pronounced radial unevenness in the stripper. Residence time distribution proved that a small portion of oil vapour could linger over 5 min before exiting despite that the apparatus may have a significantly shorter average residence time.
The Comparison in Reduction of QT Dispersion After Primary Percutaneous Coronary Intervention According to Existence of Thrombectomy in ST‐Segment Elevation Myocardial Infarction
Authors: Alici Gokhan , Sahin Muslum , Ozkan Birol , Acar Goksel , Acar Rezzan Deniz , Yazicioglu Mehmet Vefik , Bulut Mustafa , Esen Ali Metin 
Published: March 2013

AbstractBackgroundPrimary percutaneous coronary intervention (PPCI) is the standard treatment in patients with ST‐segment elevation myocardial infarction (STEMI). Thrombectomy devices are used to remove thrombus or to prevent embolization of thrombus and plaque during PPCI. QT dispersion (the difference between maximal and minimal QT interval calculated on a standard 12‐lead electrocardiogram) represents the regional nonuniformity of ventricular repolarization. It may reflect early coronary reperfusion in reducing electrophysiological instability by decreasing QT dispersion in the recovery phase after acute STEMI.HypothesisOur aim was to show whether an additional effect of thrombectomy on reducing QT dispersion will be seen in patients undergoing PPCI for STEMI.MethodsThe study population included 80 consecutive patients who were admitted to the hospital within 12 hours after the onset of acute STEMI and angiographic evidence of intraluminal thrombus in the infarct‐related artery. Patients with atrial fibrillation or flutter, intraventricular conduction abnormalities, pre‐excitation, cardiogenic shock, cardiomyopathy, ventricular hypertrophy, and severe valvular heart disease were excluded from the study.ResultsThere were no significant differences between groups regarding gender, age, cardiovascular risk factors, and time from symptom onset to treatment, except for smoking, which was much higher in the PPCI plus thrombectomy group. Infarct‐related artery distribution (left anterior descending artery [LAD] to non‐LAD), and neither the rate of balloon predilatation nor stent implantation were different between groups. Successful coronary patency was achieved in each case. QT interval measurements were similar between groups at admission. However, at 24 hours, QT and QTc dispersions were less in the PPCI plus thrombectomy group (41 ± 9 vs 33 ± 7 ms, P < 0.05 and 45 ± 8 vs 35 ± 7 ms, P = 0.03, respectively), but not in the other QT interval measurements. When patients were divided into 2 groups according to infarct‐related artery (LAD and non‐LAD groups), QT interval measurement parameters did not show any significant differences.ConclusionsThrombectomy additional to PPCI helps more effective reperfusion at the microvascular level and provides additional prognostic information.
2‐Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease
Authors: Li Zhe , Silber B. Michael , Rao Satish , Gever Joel R. , Bryant Clifford , Gallardo‐Godoy Alejandra , Dolghih Elena , Widjaja Kartika , Elepano Manuel , Jacobson Matthew P. , Prusiner Stanley B. , Renslo Adam R. 
Published: March 2013

AbstractRecently, we described the aminothiazole lead (4‐biphenyl‐4‐ylthiazol‐2‐yl)‐(6‐methylpyridin‐2‐yl)‐amine (1), which exhibits many desirable properties, including excellent stability in liver microsomes, oral bioavailability of ∼40 %, and high exposure in the brains of mice. Despite its good pharmacokinetic properties, compound 1 exhibited only modest potency in mouse neuroblastoma cells overexpressing the disease‐causing prion protein PrPSc. Accordingly, we sought to identify analogues of 1 with improved antiprion potency in ScN2a‐cl3 cells while retaining similar or superior properties. Herein we report the discovery of improved lead compounds such as (6‐methylpyridin‐2‐yl)‐[4‐(4‐pyridin‐3‐yl‐phenyl)thiazol‐2‐yl]amine and cyclopropanecarboxylic acid (4‐biphenylthiazol‐2‐yl)amide, which exhibit brain exposure/EC50 ratios at least tenfold greater than that of compound 1.
Incidence and relative survival of chordomas
Authors: Smoll Nicolas R. , Gautschi Oliver P. , Radovanovic Ivan , Schaller Karl , Weber Damien C. 
Published: March 2013

BACKGROUNDChordomas are rare bone tumors arising from remnants of the embryonic notochord.METHODSData for this study were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute (1973‐2009) to calculate the incidence, relative survival (RS), and standardized mortality ratio (SMR) of patients diagnosed with intracranial and extracranial chordomas and to assess the effects of age and sex on this disease.RESULTSThe overall incidence of extracranial and intracranial chordomas was 8.4 per 10 million population. The median overall survival of patients with chordoma patients was 7.7 years. The median survival was 7.7 years for male patients and 7.8 years for female patients. Younger patients (aged <40 years) survived longer compared with older patients (10‐year RS, 68% vs 43%). The estimated age‐standardized 5‐year, 10‐year, and 20‐year RS rates was 72%, 48%, and 31%, respectively. The SMR in the overall cohort was 4.6 (95% confidence interval, 4.22‐5.0) or 21.0 (95% confidence interval, 16.6‐27.2) in young adult patients and 3.0 (95% confidence interval, 2.6‐3.4) in elderly patients.CONCLUSIONSThe elderly had a more aggressive form of this disease; and, other than the incidence, sex did not influence outcome in this disease. The study of chordomas presents a good case for the contribution that the SMR can have on measuring the impact of a disease on a population of patients. Although the younger population has better survival rates, the impact (SMR) in the younger age groups is much higher than in older populations. Cancer 2013;119:2029–2037. © 2013 American Cancer Society.
Somatodendritic targeting of M5 muscarinic receptor in the rat ventral tegmental area: Implications for mesolimbic dopamine transmission
Authors: Garzón Miguel , Pickel Virginia M. 
Published: March 2013

ABSTRACTMuscarinic modulation of mesolimbic dopaminergic neurons in the ventral tegmental area (VTA) plays an important role in reward, potentially mediated through the M5 muscarinic acetylcholine receptor (M5R). However, the key sites for M5R‐mediated control of dopamine neurons within this region are still unknown. To address this question we examined the electron microscopic immunocytochemical localization of antipeptide antisera against M5R and the plasmalemmal dopamine transporter (DAT) in single sections through the rat VTA. M5R was located mainly to VTA somatodendritic profiles (71%; n = 627), at least one‐third (33.2%; n = 208) of which also contained DAT. The M5R immunoreactivity was distributed along cytoplasmic tubulovesicular endomembrane systems in somata and large dendrites, but was more often located at plasmalemmal sites in small dendrites, the majority of which did not express DAT. The M5R‐immunoreactive dendrites received a balanced input from unlabeled terminals forming either asymmetric or symmetric synapses. Compared with dendrites, M5R was less often seen in axon terminals, comprising only 10.8% (n = 102) of the total M5R‐labeled profiles. These terminals were usually presynaptic to unlabeled dendrites, suggesting that M5R activation can indirectly modulate non–DAT‐containing dendrites through presynaptic mechanisms. Our results provide the first ultrastructural evidence that in the VTA, M5R has a subcellular location conducive to major involvement in postsynaptic signaling in many dendrites, only some of which express DAT. These findings suggest that cognitive and rewarding effects ascribed to muscarinic activation in the VTA can primarily be credited to M5R activation at postsynaptic plasma membranes distinct from dopamine transport. J. Comp. Neurol. 521: 2927–2946, 2013. © 2013 Wiley Periodicals, Inc.
Muscle ciliary neurotrophic factor receptor α promotes axonal regeneration and functional recovery following peripheral nerve lesion
Authors: Lee Nancy , Spearry Rachel P. , Leahy Kendra M. , Robitz Rachel , Trinh Dennis S. , Mason Carter O. , Zurbrugg Rebekah J. , Batt Myra K. , Paul Richard J. , Maclennan A. John 
Published: March 2013

ABSTRACTCiliary neurotrophic factor (CNTF) administration maintains, protects, and promotes the regeneration of both motor neurons (MNs) and skeletal muscle in a wide variety of models. Expression of CNTF receptor α (CNTFRα), an essential CNTF receptor component, is greatly increased in skeletal muscle following neuromuscular insult. Together the data suggest that muscle CNTFRα may contribute to neuromuscular maintenance, protection, and/or regeneration in vivo. To directly address the role of muscle CNTFRα, we selectively‐depleted it in vivo by using a “floxed” CNTFRα mouse line and a gene construct (mlc1f‐Cre) that drives the expression of Cre specifically in skeletal muscle. The resulting mice were challenged with sciatic nerve crush. Counting of nerve axons and retrograde tracing of MNs indicated that muscle CNTFRα contributes to MN axonal regeneration across the lesion site. Walking track analysis indicated that muscle CNTFRα is also required for normal recovery of motor function. However, the same muscle CNTFRα depletion unexpectedly had no detected effect on the maintenance or regeneration of the muscle itself, even though exogenous CNTF has been shown to affect these functions. Similarly, MN survival and lesion‐induced terminal sprouting were unaffected. Therefore, muscle CNTFRα is an interesting new example of a muscle growth factor receptor that, in vivo under physiological conditions, contributes much more to neuronal regeneration than to the maintenance or regeneration of the muscle itself. This novel form of muscle–neuron interaction also has implications in the therapeutic targeting of the neuromuscular system in MN disorders and following nerve injury. J. Comp. Neurol. 521: 2947–2965, 2013. © 2013 Wiley Periodicals, Inc.
Bare Clusters Derived from Protein Templates: Au25+, Au38+ and Au102+
Authors: Baksi Ananya , Pradeep Thalappil , Yoon Bokwon , Yannouleas Constantine , Landman Uzi 
Published: March 2013

AbstractA discrete sequence of bare gold clusters of well‐defined nuclearity, namely Au25+, Au38+ and Au102+, formed in a process that starts from gold‐bound adducts of the protein lysozyme, were detected in the gas phase. It is proposed that subsequent to laser desorption ionization, gold clusters form in the gas phase, with the protein serving as a confining growth environment that provides an effective reservoir for dissipation of the cluster aggregation and stabilization energy. First‐principles calculations reveal that the growing gold clusters can be electronically stabilized in the protein environment, achieving electronic closed‐shell structures as a result of bonding interactions with the protein. Calculations for a cluster with 38 gold atoms reveal that gold interaction with the protein results in breaking of the disulfide bonds of the cystine units, and that the binding of the cysteine residues to the cluster depletes the number of delocalized electrons in the cluster, resulting in opening of a super‐atom electronic gap. This shell‐closure stabilization mechanism confers enhanced stability to the gold clusters. Once formed as stable magic number aggregates in the protein growth medium, the gold clusters become detached from the protein template and are observed as bare Aun+ (n=25, 38, and 102) clusters.
Potassium‐Doped Zinc Oxide as Photocathode Material in Dye‐Sensitized Solar Cells
Authors: Bai Jie , Xu Xiaobao , Xu Ling , Cui Jin , Huang Dekang , Chen Wei , Cheng Yibing , Shen Yan , Wang Mingkui 
Published: March 2013

AbstractZnO nanoparticles are doped with K and applied in p‐type dye‐sensitized solar cells (DSCs). The microstructure and dynamics of hole transportation and recombination are investigated. The morphology of the K‐doped ZnO nanoparticles shows a homogeneous distribution with sizes in the range 30–40 nm. When applied in p‐type DSCs in combination with C343 as sensitizer, the K‐doped ZnO nanoparticles achieve a photovoltaic power conversion efficiency of 0.012 % at full‐intensity sunlight. A further study on the device by transient photovoltage/photocurrent decay measurements shows that the K‐doped ZnO nanoparticles have an appreciable hole diffusion coefficient (ca. 10−6 cm2 s−1). Compared to the widely used p‐type NiO nanoparticles, this advantage is crucial for further improving the efficiency of p‐type DSCs.
ESTELL: A Quasi‐Toroidally Symmetric Stellarator
Authors: Drevlak M. , Brochard F. , Helander P. , Kisslinger J. , Mikhailov M. , Nührenberg C. , Nührenberg J. , Turkin Y. 
Published: March 2013

AbstractThis work presents the physics design for a simple quasi‐axially symmetric stellarator. A plasma configuration described by a modest number of Fourier coefficients was found to establish this symmetry with good accuracy. The low rotational transform results in a relatively simple coil set exhibiting low curvatures and comfortable clearance between adjacent coils. As another consequence, the maximum achievable plasma pressure will be limited to about 0.5%. An experiment along the lines proposed would allow an exploration of the confinement properties of a quasi‐axially symmetric configuration. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)