bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous Matrix-Induced Chondrogenesis in the Knee
Authors: Lee Yee Han Dave , Suzer Ferzan , Thermann Hajo 
Published: April 2014

Objective: Autologous matrix-induced chondrogenesis (AMIC) is a 1-step cartilage restoration technique that combines microfracture with the use of an exogenous scaffold. This matrix covers and mechanically stabilizes the clot. There have been an increasing number of studies performed related to the AMIC technique and an update of its use and results is warranted. Design and methods: Using the PubMed database, a literature search was performed using the terms “AMIC” or “Autologous Matrix Induced Chondrogenesis.” A total of 19 basic science and clinical articles were identified. Results: Ten studies that were published on the use of AMIC for knee chondral defects were identified and the results of 219 patients were analyzed. The improvements in Knee Injury and Osteoarthritis Outcome Score, International Knee Documentation Committee Subjective, Lysholm and Tegner scores at 2 years were comparable to the published results from autologous chondrocyte implantation (ACI) and matrix ACI techniques for cartilage repair. Conclusions: Our systematic review of the current state of the AMIC technique suggests that it is a promising 1-stage cartilage repair technique. The short-term clinical outcomes and magnetic resonance imaging results are comparable to other cell-based methods. Further studies with AMIC in randomized studies versus other repair techniques such as ACI are needed in the future.
Pain reporting in older adults: the influence of cognitive impairment – results from the Cambridge City >75 Cohort study
Authors: Docking Rachael E , Fleming Jane , Brayne Carol , Zhao Jun , Macfarlane Gary J , Jones Gareth T ,   The Cambridge City over-75s Cohort (CC75C) study collaboration
Published: April 2014

Objectives: Evidence suggests that while disabling back pain (BP), and rheumatic diseases associated with pain, continues to increase with age, the prevalence of non-disabling BP reaches a plateau, or even decreases, in the oldest old. This study aimed to determine whether this age-related pattern of non-disabling BP is a function of increasing cognitive impairment. Methods: Cross-sectional study of adults aged >77 years. Participants answered interviewer-administered questions on BP and cognitive function, assessed using the Mini-Mental State Examination, categorised into normal versus mild, moderate or severe impairment. The relationship between cognitive function and BP was examined using multinomial logistic regression, adjusted for age, sex and residence. Results: Of 1174 participants with BP data, 1126 (96%) completed cognitive assessments. The relationship between cognitive function and BP differed for disabling and non-disabling BP. Across categories of cognitive impairment, increasingly higher prevalence of disabling BP was reported, compared to those with normal cognition, although this was not statistically significant (odds ratio (OR) = 1.7; 95% confidence interval (CI) = 0.7–4.6). No association was found between cognitive function and non-disabling BP (OR = 0.8; 95% CI = 0.4–1.6). Conclusion: This study found no association between the reporting of BP and level of cognitive impairment, suggesting that increasing cognitive impairment is an inadequate explanation for age-related decline in self-reported non-disabling BP. Future research should determine the reasons for the decline in non-disabling pain in older adults, although, meanwhile, it is important to ensure that this group receive appropriate pain assessment and pain management. Key points Prevalence of non-disabling back pain decreases in the oldest old. Some have proposed that this may be a function of cognitive impairment in older age, and an increasing inability to adequately report pain. Our findings do not support this hypothesis.
Does classroom-based Crew Resource Management training improve patient safety culture? A systematic review
Authors: Verbeek-van Noord Inge , de Bruijne Martine C , Zwijnenberg Nicolien C , Jansma Elise P , van Dyck Cathy , Wagner Cordula 
Published: April 2014

Aim: To evaluate the evidence of the effectiveness of classroom-based Crew Resource Management training on safety culture by a systematic review of literature. Methods: Studies were identified in PubMed, Cochrane Library, PsycINFO, and Educational Resources Information Center up to 19 December 2012. The Methods Guide for Comparative Effectiveness Reviews was used to assess the risk of bias in the individual studies. Results: In total, 22 manuscripts were included for review. Training settings, study designs, and evaluation methods varied widely. Most studies reporting only a selection of culture dimensions found mainly positive results, whereas studies reporting all safety culture dimensions of the particular survey found mixed results. On average, studies were at moderate risk of bias. Conclusion: Evidence of the effectiveness of Crew Resource Management training in health care on safety culture is scarce and the validity of most studies is limited. The results underline the necessity of more valid study designs, preferably using triangulation methods.
Cerebral contrast retention after difficult cardiac catheterization: Case report
Authors: Khan Shahid M , Ho David W , Lazar Jason M , Marmur JD 
Published: April 2014

Background: We report a diagnostic dilemma in a rare case of cerebral contrast retention after difficult cardiac catheterization in an elderly patient loaded with prasugrel. Summary: Our case report describes a 77-year-old female with history of hypertension, diabetes, and dyslipidemia who presented to emergency department complaining of chest pain. Patient was found to have an inferior wall ST elevation myocardial infarction. The patient was loaded with aspirin and prasugrel and taken for emergent cardiac catheterization. Cardiac catheterization revealed two-vessel coronary artery disease with unsuccessful attempt of percutaneous intervention. Immediately after procedure, patient developed an episode of seizure. Emergent computed tomography scan of the brain revealed hyperdensity in the right frontoparietal region consistent with intracerebral bleed. Repeat computed tomography (24 h later) revealed substantial interval improvement of hyperdensity. Follow-up magnetic resonance imaging of the head was normal. Given the lack of magnetic resonance imaging changes, the rate of resolution on computed tomography without expected subacute changes, and the lack of neurologic findings, the initial hyperdensity seen on computed tomography of the brain was believed to be secondary to contrast leakage during cardiac catheterization as opposed to intracranial hemorrhage.
Swelling of bilateral parotid glands: An unusual symptom of multisystem Langerhans cell histiocytosis
Authors: Yuan Xiaojun , Tang Mengjie , Sheng Qi , Zhu Xiaodong , Zhang Qin 
Published: April 2014

Objective: Langerhans cell histiocytosis is an unusual disorder of unknown etiology with heterogeneous clinical behaviors and variable outcomes. It can involve one or more organs or systems, but to our best knowledge, parotid glands involvement in Langerhans cell histiocytosis is extremely rare in English literature. Method: We report a 13-month-old girl who presented with bilateral parotid swelling as presenting symptom. She was misdiagnosed for 4 months, but final diagnosis was multisystem Langerhans cell histiocytosis. Result: After being treated for 18 months, the patient acquired complete remission and attained similar growth status to other healthy children. Conclusion: Langerhans cell histiocytosis may involve any organ; in patients with parotid enlargement, Langerhans cell histiocytosis should be kept in mind in the differential diagnoses. We emphasize the importance of biopsy for histologic evaluation as soon as possible and even repeatedly if initial results are negative for Langerhans cell histiocytosis.
Certain Grüss type inequalities involving the generalized fractional integral operator
Authors: Wang Guotao , Agarwal Praveen , Chand Mehar 
Published: April 2014

Abstract
A remarkably large number of Grüss type fractional integral inequalities involving the special function have been investigated by many authors. Very recently, Kalla and Rao (Matematiche LXVI(1):57-64, 2011) gave two Grüss type inequalities involving the Saigo fractional integral operator. Using the same technique, in this paper, we establish certain new Grüss type fractional integral inequalities involving the Gauss hypergeometric function. Moreover, we also consider their relevances for other related known results.

MSC: 26D10, 26A33.
Determining the prevalence and predictors of sleep disordered breathing in patients with chronic heart failure: rationale and design of the SCHLA-HF registry
Authors: Woehrle Holger , Oldenburg Olaf , Arzt Michael , Graml Andrea , Erdmann Erland , Teschler Helmut , Wegscheider Karl ,   the SCHLA-HF Investigators
Published: April 2014

Abstract

Background
The objective of the SCHLA-HF registry is to investigate the prevalence of sleep-disordered breathing (SDB) in patients with chronic heart failure with reduced left ventricular systolic function (HF-REF) and to determine predictors of SDB in such patients.

Methods
Cardiologists in private practices and in hospitals in Germany are asked to document patients with HF-REF into the prospective SCHLA-HF registry if they meet predefined inclusion and exclusion criteria. Screening was started in October 2007 and enrolment was completed at the end of May 2013. After enrolment in the registry, patients are screened for SDB. SDB screening is mainly undertaken using the validated 2-channel ApneaLink™ device (nasal flow and pulse oximetry; ResMed Ltd., Sydney, Australia). Patients with a significant number of apneas and hypopneas per hour recording time (AHI ≥15/h) and/or clinical symptoms suspicious of SDB will be referred to a cooperating sleep clinic for an attended in-lab polysomnography with certified scoring where the definite diagnosis and, if applicable, the differentiation between obstructive and central sleep apnea will be made. Suggested treatment will be documented.

Discussion
Registries play an important role in facilitating advances in the understanding and management of cardiovascular disease. The SCHLA-HF registry will provide consistent data on a large group of patients with HF-REF that will help to answer questions on the prevalence, risk factors, gender differences and stability of SDB in these patients by cross-sectional analyses. Further insight into the development of SDB will be gained by extension of the registry to include longitudinal data.
Expression of energy metabolism related genes in the gastric tissue of obese individuals with non-alcoholic fatty liver disease
Authors: Mehta Rohini , Birerdinc Aybike , Wang Lei , Younoszai Zahra , Moazzez Amir , Elariny Hazem , Goodman Zachary , Chandhoke Vikas , Baranova Ancha , Younossi Zobair M 
Published: April 2014

Abstract

Background
Stomach is an integral part of the energy balance regulating circuit. Studies exploring the effects of cross-system changes in the energy homeostasis in stomach tissue are scarce. The proximity of the stomach to liver - the most common secondary target affected by obesity – suggests that these two organs are exposed to each other’s local secretion. Therefore, we aimed at expression profiling of energy metabolism associated genes in the gastric tissue of obese non-alcoholic fatty liver disease (NAFLD) patients.

Methods
A total of 24 patients with histologically-proven NAFLD were included. In the gastric tissue, gene expression profiling of 84 energy metabolism associated genes was carried out.

Results
The accumulation of the fat in the liver parenchyma is accompanied by downregulation of genes encoding for carboxypeptidase E (CPE) and Interleukin 1B (IL1B) in the gastric mucosa of same patient. In patients with high grade hepatic steatosis, Interleukin 1 beta encoding gene with anorexigenic function, IL1B was downregulated. The levels expression of 21 genes, including ADRA2B, CNR1 and LEP were significantly altered in the gastric tissue of NAFLD patients with hepatic inflammation. There were also indications of an increase in the opioid signaling within gastric mucosa that may results in a shift to proinflammatory environment within this organ and contribute to systemic inflammation and the pathogenic processes in hepatic parenchyma.

Conclusions
We have shown differential expression of energy metabolism associated genes in the gastric tissue of obese NAFLD patients. Importantly, these gene expression profiles are associated with changes in the hepatic parenchyma as reflected in increased scores for hepatic steatosis, inflammation, fibrosis and NASH. This study suggests the complex interplay of multiple organs in the pathogenesis of obesity-related complications such as NAFLD and provides further evidence supporting an important role for gastric tissue in promoting obesity-related complications.
The implicit midpoint rule for nonexpansive mappings
Authors: Alghamdi Maryam A , Alghamdi Mohammad Ali , Shahzad Naseer , Xu Hong-Kun 
Published: April 2014

Abstract
The implicit midpoint rule (IMR) for nonexpansive mappings is established. The IMR generates a sequence by an implicit algorithm. Weak convergence of this algorithm is proved in a Hilbert space. Applications to the periodic solution of a nonlinear time-dependent evolution equation and to a Fredholm integral equation are included.

MSC:47J25, 47N20, 34G20, 65J15.
Development and application of MIPAR™: a novel software package for two- and three-dimensional microstructural characterization
Authors: Sosa John M , Huber Daniel E , Welk Brian , Fraser Hamish L 
Published: April 2014

AbstractThree-dimensional microscopy has become an increasingly popular materials characterization technique. This has resulted in a standardized processing scheme for most datasets. Such a scheme has motivated the development of a robust software package capable of performing each stage of post-acquisition processing and analysis. This software has been termed Materials Image Processing and Automated Reconstruction (MIPAR™). Developed in MATLAB™, but deployable as a standalone cross-platform executable, MIPAR™ leverages the power of MATLAB’s matrix processing algorithms and offers a comprehensive graphical software solution to the multitude of 3D characterization problems. MIPAR™ consists of five modules, three of which (Image Processor, Batch Processor, and 3D Toolbox) are required for full 3D characterization. Each module is dedicated to different stages of 3D data processing: alignment, pre-processing, segmentation, visualization, and quantification.With regard to pre-processing, i.e., the raw-intensity-enhancement steps that aid subsequent segmentation, MIPAR’s Image Processor module includes a host of contrast enhancement and noise reduction filters, one of which offers a unique solution to ion-milling-artifact reduction. In the area of segmentation, a methodology has been developed for the optimization of segmentation algorithm parameters, and graphically integrated into the Image Processor. Additionally, a 3D data structure and complementary user interface has been developed which permits the binary segmentation of complex, multi-phase microstructures. This structure has also permitted the integration of 3D EBSD data processing and visualization tools, along with support of additional algorithms for the fusion of multi-modal datasets. Finally, in the important field of quantification, MIPAR™ offers several direct 3D quantification tools across the global, feature-by-feature, and localized classes.
Adjuvant selenium supplementation in the form of sodium selenite in postoperative critically ill patients with severe sepsis
Authors: Sakr Yasser , Maia Vivian PL , Santos Clesar , Stracke Julia , Zeidan Mohamed , Bayer Ole , Reinhart Konrad 
Published: April 2014

Abstract
Introduction
Plasma selenium (Se) concentrations are reduced in critically ill surgical patients, and lower plasma Se concentrations are associated with worse outcomes. We investigated whether adjuvant Se supplementation in the form of sodium selenite could improve outcomes in surgical patients with sepsis.

Methods
In this retrospective study, all adult patients admitted to a 50-bed surgical ICU with severe sepsis between January 2004 and April 2010 were included and analysed according to whether they had received adjuvant Se supplementation, which was given at the discretion of the attending physician. When prescribed, Se was administered in the form of sodium selenite pentahydrate (Na2SeO3∙5H2O), in which 100 μg of Se corresponds to 333 μg of sodium selenite. A bolus of sodium selenite corresponding to 1,000 μg of Se was injected intravenously through a central venous line for 30 minutes, followed by infusion of 1,000 μg/day for 24 hours for 14 days until ICU discharge or death. We performed logistic regression analysis to investigate the impact of adjuvant Se supplementation on hospital mortality.

Results
Adjuvant Se was administered to 413 (39.7%) of the 1,047 patients admitted with severe sepsis. Age and sex were similar between patients who received adjuvant Se and those who did not. Compared with patients who did not receive adjuvant Se supplementation, patients who did had higher scores on the Simplified Acute Physiology Score II, a greater prevalence of cancer upon admission to the ICU and were more commonly admitted after abdominal surgery. Compared with patients who did not receive adjuvant Se, patients who did had higher hospital mortality rates (46% versus 39.1%; P = 0.027), and longer median (interquartile range (IQR)) ICU stays (15 days (6 to 24) versus 11 days (4 to 24); P = 0.01) and hospital lengths of stay (33 days (21 to 52) versus 28 days (17 to 46); P = 0.001). In multivariable analysis, adjuvant Se supplementation was not independently associated with favourable outcome (odds ratio = 1.19, 95% confidence interval = 0.86 to 1.65; P = 0.288).

Conclusions
In this retrospective analysis of a large cohort of surgical ICU patients with severe sepsis, adjuvant Se supplementation in the form of sodium selenite had no impact on in-hospital death rates after adjustment for confounders.
The impact of heatwaves on emergency department visits in Brisbane, Australia: a time series study
Authors: Toloo Ghasem Sam , Yu Weiwei , Aitken Peter , FitzGerald Gerry , Tong Shilu 
Published: April 2014

Abstract
Introduction
The acute health effects of heatwaves in a subtropical climate and their impact on emergency departments (ED) are not well known. The purpose of this study is to examine overt heat-related presentations to EDs associated with heatwaves in Brisbane.

Methods
Data were obtained for the summer seasons (December to February) from 2000–2012. Heatwave events were defined as two or more successive days with daily maximum temperature ≥34°C (HWD1) or ≥37°C (HWD2). Poisson generalised additive model was used to assess the effect of heatwaves on heat-related visits (International Classification of Diseases (ICD) 10 codes T67 and X30; ICD 9 codes 992 and E900.0).

Results
Overall, 628 cases presented for heat-related illnesses. The presentations significantly increased on heatwave days based on HWD1 (relative risk (RR) = 4.9, 95% confidence interval (CI): 3.8, 6.3) and HWD2 (RR = 18.5, 95% CI: 12.0, 28.4). The RRs in different age groups ranged between 3–9.2 (HWD1) and 7.5–37.5 (HWD2). High acuity visits significantly increased based on HWD1 (RR = 4.7, 95% CI: 2.3, 9.6) and HWD2 (RR = 81.7, 95% CI: 21.5, 310.0). Average length of stay in ED significantly increased by >1 hour (HWD1) and >2 hours (HWD2).

Conclusions
Heatwaves significantly increase ED visits and workload even in a subtropical climate. The degree of impact is directly related to the extent of temperature increases and varies by socio-demographic characteristics of the patients. Heatwave action plans should be tailored according to the population needs and level of vulnerability. EDs should have plans to increase their surge capacity during heatwaves.
Continuous venovenous hemofiltration versus extended daily hemofiltration in patients with septic acute kidney injury: a retrospective cohort study
Authors: Sun Zhiping , Ye Hong , Shen Xia , Chao Hongdi , Wu Xiaochun , Yang Junwei 
Published: April 2014

Abstract
Introduction
Whether continuous venovenous hemofiltration (CVVHF) is superior to extended daily hemofiltration (EDHF) for the treatment of septic AKI is unknown. We compared the effect of CVVHF (greater than 72 hours) with EDHF (8 to 12 hours daily) on renal recovery and mortality in patients with severe sepsis or septic shock and concurrent acute kidney injury (AKI).

Methods
A retrospective analysis of 145 septic AKI patients who underwent renal replacement therapy (RRT) between July 2009 and May 2013 was performed. These patients were treated by CVVHF or EDHF with the same polyacrylonitrile membrane and bicarbonate-based buffer. The primary outcomes measured were occurrence of renal recovery and all-cause mortality by 60 days.

Results
Sixty-five and eighty patients were treated with CVVHF and EDHF, respectively. Patients in the CVVHF group had significantly higher recovery of renal function (50.77% of CVVHF group versus 32.50% in the EDHF group, P = 0.026). Median time to renal recovery was 17.26 days for CVVHF patients and 25.46 days for EDHF patients (P = 0.039). Sixty-day all-cause mortality was similar between CVVHF and EDHF groups (44.62%, and 46.25%, respectively; P = 0.844). 55.38% of patients on CVVHF and 28.75% on EDHF developed hypophosphatemia (P = 0.001). The other adverse events related to RRT did not differ between groups. On multivariate analysis, including physiologically clinical relevant variables, CVVHF therapy was significantly associated with recovery of renal function (HR 3.74; 95% CI 1.82 to 7.68; P < 0.001), but not with mortality (HR 0.69; 95% CI 0.34 to 1.41; P = 0.312).

Conclusions
Patients undergoing CVVHF therapy had significantly improved renal recovery independent of clinically relevant variables. The patients with septic AKI had similar 60-day all-cause mortality rates, regardless of type of RRT.
Induction of immunomodulatory monocytes by human mesenchymal stem cell-derived hepatocyte growth factor through ERK1/2
Authors: Chen Pei-Min , Liu Ko-Jiunn , Hsu Pei-Ju , Wei Chung-Fan , Bai Chyi-Huey , Ho Ling-Jun , Sytwu Huey-Kang , Yen B Linju 
Published: April 2014

AbstractMonocytes are a population of leukocytes that terminally differentiate into macrophages and DCs. Whereas these differentiated progeny have inflammatory and resident—which are more immunomodulatory—phenotypes, less has been reported on the plasticity of monocytes themselves. We found that MSCs, a population of somatic stem cells, can rapidly induce human and murine monocytes through secretion of HGF to acquire an immunomodulatory phenotype to suppress T cell effector function. MSCs are multilineage postnatal progenitor cells with strong immunomodulatory effects toward T lymphocytes, NK lymphocytes, and DCs, but less is known regarding their interactions with monocytes. We found that CD14+ human monocytes express c-Met, the receptor for HGF, and both depletion of HGF-treated CD14+ monocytes and knockdown of HGF secretion in MSCs abrogate the suppression of anti-CD3/28-activated T cell proliferation. HGF-treated monocytes remain undifferentiated and can alter activated T cell cytokine expression from a Th1 toward Th2 profile. Moreover, monocytes cocultured with MSCs or treated with HGF alone can produce high levels of IL-10, a potent immunomodulatory cytokine. Injection of HGF to WT mice also results in an increase in IL-10+-expressing monocytes from the spleen, a known reservoir for circulating monocytes. Mechanistically, HGFs modulate IL-10 production in monocytes through the ERK1/2 pathway. Our data demonstrate further the pleomorphic nature of MSC immunomodulation, as well as highlight the important role of immunomodulatory monocytes in altering T cell effector function.