bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of PLLA/PDLA stereocomplexes using a novel initiator based on Mg(II) and Ti(IV) alkoxides
Authors: Silvino Alexandre Carneiro , Corrêa Priscila Santos , Dias Marcos Lopes 
Published: April 2014

ABSTRACTHerein we describe the obtention of polylactide stereocomplexes using a novel initiator system comprising Mg(II) and Ti(IV) centers. The stereocomplexes were successfully prepared using two different routes: by PDLA and PLLA co‐precipitation from chloroform solutions and two‐step diblock copolymerization. For the PDLA/PLLA mixing procedure, individual homochiral polymers were prepared in solution at different monomer/initiator ratios; whereas, the PLA stereoblock was prepared employing one‐pot sequential polymerization of both chiral monomers. The products analyzed by WAXD showed the characteristic stereocrystal reflections while the high melting temperatures found in the DSC runs confirmed the formation of PLA stereocomplexes in both cases. Surprisingly, one of the stereocomplexes showed a second endothermic event at 250.1°C and to our knowledge this is the highest melting temperature reported for PLA stereocomplexes till date. These results point to the discovery of an effective initiator based on low toxicity metals for the preparation of biodegradable materials with interesting thermal properties. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40771.
Thermodynamic and kinetic aspects of defectivity in directed self‐assembly of cylinder‐forming diblock copolymers in laterally confining thin channels
Authors: Kim Bongkeun , Laachi Nabil , Delaney Kris T. , Carilli Michael , Kramer Edward J. , Fredrickson Glenn H. 
Published: April 2014

ABSTRACTWe use self‐consistent field theory to calculate the energy of defect formation in cylinder‐forming diblock copolymers in laterally confining thin channels. We focus on two isolated defects, dislocations and disclinations and explore a wide range of polymer and channel characteristics. Our findings suggest appropriate conditions for the design of optimized graphoepitaxial processes, where defects are limited to very low concentrations. Using the string method, we also investigate the energy barriers and kinetic pathways of the transition from defective to perfect states. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40790.
Morphology controlled synthesis of polyaniline nanostructures using swollen liquid crystal templates
Authors: Dutt Sunil , Siril Prem Felix 
Published: April 2014

ABSTRACTPreparation of zero‐dimensional and one‐dimensional nanostructures of polyaniline (PANI) were achieved by using swollen liquid crystals (SLCs) as ‘soft' templates. The monomer (aniline) was first entrapped in SLCs by replacing the oil phase (cyclohexane) with a mixture of aniline and cyclohexane. Zero‐dimensional nanostructures of PANI were obtained by thorough mixing of APS with the mesophases. One‐dimensional nanostructures were prepared by allowing slow diffusion of APS through the mesophase. PANI nanostructures were extracted from the mesophase and were characterized by UV‐visible spectroscopy, FTIR spectroscopy, powder X‐ray diffraction, atomic force microscopy, scanning electron microscopy (SEM), and conductivity measurements. A plausible mechanism for the formation of the nanostructures has been proposed. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2014,131, 40800.
Intraarticular Sprifermin (Recombinant Human Fibroblast Growth Factor 18) in Knee Osteoarthritis: A Randomized, Double‐Blind, Placebo‐Controlled Trial
Authors: Lohmander L. Stefan , Hellot Scarlett , Dreher Don , Krantz Eduard F. W. , Kruger Dawie S. , Guermazi Ali , Eckstein Felix 
Published: April 2014

ObjectiveTo evaluate the efficacy and safety of intraarticular sprifermin (recombinant human fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA).MethodsThe study was a randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial. Intraarticular sprifermin was evaluated at doses of 10 μg, 30 μg, and 100 μg. The primary efficacy end point was change in central medial femorotibial compartment cartilage thickness at 6 months and 12 months as determined using quantitative magnetic resonance imaging (qMRI). The primary safety end points were nature, incidence, and severity of local and systemic treatment‐emergent adverse events (AEs) and acute inflammatory reactions, as well as results of laboratory assessments. Secondary end points included changes in total and compartment femorotibial cartilage thickness and volume as assessed by qMRI, changes in joint space width (JSW) seen on radiographs, and pain scores on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).ResultsOne hundred ninety‐two patients were randomized and evaluated for safety, 180 completed the trial, and 168 were evaluated for the primary efficacy end point. We found no statistically significant dose response in change in central medial femorotibial compartment cartilage thickness. Sprifermin was associated with statistically significant, dose‐dependent reductions in loss of total and lateral femorotibial cartilage thickness and volume and in JSW narrowing in the lateral femorotibial compartment. All groups had improved WOMAC pain scores, with statistically significantly less improvement at 12 months in patients receiving the 100‐μg dose of sprifermin as compared with those receiving placebo. There was no significant difference in serious AEs, treatment‐emergent AEs, or acute inflammatory reactions between sprifermin and placebo groups.ConclusionNo statistically significant relationship between treatment group and reduction in central medial femorotibial compartment cartilage thickness was observed; however, prespecified structural secondary end points showed statistically significant dose‐dependent reductions after sprifermin treatment. Sprifermin was not associated with any local or systemic safety concerns.
Local Monin–Obukhov similarity in heterogeneous terrain
Authors: Figueroa‐Espinoza Bernardo , Salles Paulo 
Published: April 2014

AbstractExperimental results concerning turbulence in a coastal zone are presented. The presence of internal boundary layers and advection in complex terrain precludes the use of Monin–Obukhov similarity theory (MOST) to estimate effective values of the turbulent transport (of momentum and heat) parameters. However, the use of local Monin–Obukhov similarity is less restrictive: if an analogy is made between the stability integrated functions for horizontally homogeneous terrain and a corresponding term in complex terrain, effective values of the Obukhov and roughness lengths can be obtained using sonic anemometry.
Hepatic microsomal UDP‐glucuronosyltransferase (UGT) activities in the microminipig
Authors: Higashi Eriko , Ando Akihiro , Iwano Shunsuke , Murayama Norie , Yamazaki Hiroshi , Miyamoto Yohei 
Published: April 2014

ABSTRACTThe microminipig, a small minipig, was bred as a novel experimental animal for nonclinical pharmacology/toxicology studies by Fuji Micra Inc. (Shizuoka, Japan). Species differences in drug metabolism between humans and the microminipig need to be elucidated in more detail in order to discuss the results of nonclinical studies. Glucuronidation catalysed by UDP‐glucuronosyltransferase (UGT) is an important pathway in the metabolism of a wide variety of compounds. The aim of the present study was to identify the characteristics of hepatic UGT activity in the microminipig and compare them with those in humans and other experimental animals. This study examined in vitro UGT activities using liver microsomes from microminipigs (8 months old and 1 day old), humans, mice, rats, dogs, monkeys and minipigs. The glucuronides of estradiol, imipramine, serotonin, propofol, 3′‐azido‐3′‐deoxythymidine (AZT) and morphine, selective substrates of human UGT1A1, 1A4, 1A6, 1A9 and 2B7 (AZT and morphine), respectively, were measured using LC‐MS/MS. Estradiol‐3‐glucuronidation activity was higher in the microminipig than in humans and the other animals. High levels of estradiol‐3‐glucuronidation were observed in the microsomes of 1‐day‐old microminipigs. Imipramine‐N‐glucuronidation, a distinctive conjugation by human UGT1A4, was catalysed by microminipig liver microsomes, but not by dog liver microsomes. Although AZT‐glucuronidation activity was low in the microminipig compared with humans, morphine‐3‐glucuronidation activity in the microminipig was higher than that in humans. The UGT activities in the microminipig were similar to those in the minipig. The results of the present study have provided useful information for selecting an appropriate animal model for nonclinical studies. Copyright © 2014 John Wiley & Sons, Ltd.
Avoiding antibody aggregation during processing: Establishing hold times
Authors: Joshi Varsha , Shivach Tarun , Kumar Vijesh , Yadav Nitin , Rathore Anurag 
Published: April 2014

AbstractAggregation of biotech products used therapeutically, such as antibodies, can contribute to potential immunogenicity of the product. Charge‐based heterogeneities may also impact the safety and/or efficacy of a therapeutic. In this study, an approach based on empirical modeling and least squares regression is suggested for establishing hold times for process intermediates during production of monoclonal antibody (Mab) therapeutics. Two immunoglobulins were analyzed with respect to aggregation and charge heterogeneity in buffer conditions that are typically used during downstream processing of Mab products. Size exclusion chromatography, ion exchange chromatography (IEC), and circular dichroism were used. We found that aggregation primarily occurs at pH 3 (buffers used in affinity chromatography) and is higher in citrate buffer compared to acetate and glycine buffers. Aggregation is minimal in buffers used in anion exchange chromatography (Tris–HCl buffer at pH 7.2 and 8) and in cation exchange chromatography (citrate buffer at pH 6, acetate buffer at pH 6, and phosphate buffer at pH 6.5 and 7.5). The behavior is opposite in the case of charged heterogeneities (basic and acidic variants) as measured by IEC. The product is more susceptible to degradation at high pH than at low pH. The data presented here demonstrate that product stability can be a significant issue within the routinely used manufacturing conditions. We suggest that the approach presented needs to be adopted by all manufacturers to ensure product stability during processing.
Influence of PEG length on conformational and binding properties of CCK peptides exposed by supramolecular aggregates
Authors: Accardo Antonella , Ringhieri Paola , Palumbo Rosanna , Morelli Giancarlo 
Published: April 2014

ABSTRACTFive novel peptide amphiphiles (PAs), with common formula (C18)2‐PEGx‐CCK8 in which the CCK8 peptide and the (C18)2‐hydrophobic moiety are spaced by polyethylene linkers of different length (PEG moieties with molecular weights of 700, 1000, 1500, 2000, and 3000 Daltons) are described. They act as potential target‐selective nanocarriers towards tumor cells overexpressing cholecistokynin receptors. PAs self‐assemble in supramolecular aggregates, with hydrodynamic radius ranging between 63 and 104 nm, as indicated by DLS measurements. Fluorescence studies suggested that, irrespective from the PEG length, the tryptophan residue located at the center of the CCK8 sequence is completely surrounded by water molecules at high mobility. This result indicates a potential capability of all formulated nanovectors to recognize the overexpressed CCK‐2 receptors. CD data suggest that CCK8 peptide, in most of PAs in their aggregate form, adopts a conformation allowing the interaction with the receptor. Anyway, biological data obtained by flow cytometry analysis indicate that the five PAs have a different binding ability towards the CCK‐2 receptors, with higher binding properties shown by PA containing PEG with MW of 2000 Dalton. Therefore, PEG2000 can be considered as the best spacer in the formulation of nanovectors based on CCK8 peptide amphiphiles. © 2014 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 102: 304–312, 2014.
ChemInform Abstract: Preparation, Electronic Structure and Luminescence Properties of Ce3+‐Activated CaZnOS under UV and X‐Ray Excitation.
Authors: Zhang Zhi‐Jun , Feng Ang , Sun Xin‐Yuan , Guo Kai , Man Zhen‐Yong , Zhao Jing‐Tai 
Published: April 2014

AbstractCa1‐2xCexLixZnOS samples (0 ≤ x ≤ 0.15) are prepared by a solid‐state reaction of CaO, ZnS, Li2CO3, and CeO2 (5% H2/N2 reducing atmosphere, Mo crucible, 950—1050 °C, 48 h).
ChemInform Abstract: Crystal Growth, Nonlinear Frequency‐Doubling and Spectral Characteristic of Nd:Ca9La(VO4)7 Crystal.
Authors: Zhuang Naifeng , Liu Xiaofeng , Xu Qianrui , Chen Xin , Zhao Bin , Hu Xiaolin , Chen Jianzhong 
Published: April 2014

AbstractPure and Nd‐doped Ca9La(VO4)7 crystals with various Nd3+ levels (3.2, 18.9, 31.4, and 32 at.%) are grown by the Czochralski method at 1430 °C from powders prepared by solid state reaction of a stoichiometric mixture of CaCO3, V2O5, La2O3, and Nd2O3 (alumina crucible, 1000 °C, 8 h).
ChemInform Abstract: High‐Temperature Thermoelectric Properties of the Solid—Solution Zintl Phase Eu11Cd6Sb12‐xAsx (x < 3).
Authors: Kazem Nasrin , Xie Weiwei , Ohno Saneyuki , Zevalkink Alexandra , Miller Gordon J. , Snyder G. Jeffrey , Kauzlarich Susan M. 
Published: April 2014

AbstractSingle crystals of the title compounds are prepared from the elements in a Sn flux (alumina crucibles, 950 °C, 96 h) and characterized by powder and single crystal XRD, transport properties measurements, and TB‐LMTO‐ASA electronic structure calculations.
ChemInform Abstract: Electronic Structure and Electrical Properties of Ba2LaTaO6.
Authors: Kumari Premlata , Dutta Alo , Shannigrahi Santiranjan , Prasad S. , Sinha T. P. 
Published: April 2014

AbstractBa2LaTaO6 is prepared by solid state reaction of a stoichiometric mixture of BaCO3, La2O3, and Ta2O5 (1350 °C, 6 h).
ChemInform Abstract: Magnetic and Magnetocaloric Properties of Equiatomic Alloys RAl (R: Ho and Er).
Authors: Yang L. H. , Zhang H. , Hu F. X. , Sun J. R. , Pan L. Q. , Shen B. G. 
Published: April 2014

AbstractHoAl and ErAl intermetallics are prepared by melting of the elements under Ar followed by annealing (1173 K, 30 d) and quenching in liquid N2.
ChemInform Abstract: A New Cesium Pentaborate with New B10O19 Building Blocks.
Authors: Jiao Anqing , Yu Hongwei , Wu Hongping , Pan Shilie , Zhang Xingwen 
Published: April 2014

AbstractSingle crystals of a new polymorph of CsB5O8 are grown from a mixture of Cs2CO3, H3BO3, and MoO3 in a molar ratio of 1:4:2 (Pt crucible, 650 °C, 20 h; controlled cooling).
ChemInform Abstract: Enantioselective Protonation of Alkenyl Trifluoroacetates Catalyzed by Chiral Tin Methoxide.
Authors: Yanagisawa Akira , Sugita Takuya , Yoshida Kazuhiro 
Published: April 2014

AbstractOptically active ketones containing a tertiary stereogenic center at the α‐position are obtained by catalytic enantioselective protonation of alkenyl trifluoroacetates.
ChemInform Abstract: Boron‐Trihalide‐Promoted Regioselective Ring‐Opening Reactions of gem‐Difluorocyclopropyl Ketones.
Authors: Yang Tang‐Po , Li Qiang , Lin Jin‐Hong , Xiao Ji‐Chang 
Published: April 2014

AbstractThe presented strategy offers a straightforward access to beta‐halodifluoromethyl substituted ketones which are difficult to prepare using other methods.
ChemInform Abstract: Diversity‐Oriented Synthesis of Hydrazine‐Derived Compounds from Amino Isocyanates Generated in situ.
Authors: Clavette Christian , Rocan Jean‐Francois Vincent , Beauchemin Andre M. 
Published: April 2014

AbstractSimple O‐phenyl‐substituted carbazates can form amphoteric amino isocyanate intermediates in situ.
ChemInform Abstract: Highly Diastereoselective Esterification of Ketenes Generated in situ from Acyl Chlorides with (R)‐Pantolactone Derivatives.
Authors: Yamagami Takafumi , Hatsuda Masanori , Utsugi Masayuki , Kobayashi Ryo , Moritani Yasunori 
Published: April 2014

AbstractThe use of NEt3 is found to be important to achieve high diastereoselectivity in this reaction.
ChemInform Abstract: Pd‐Catalyzed Ethylene Methoxycarbonylation with Broensted Acid Ionic Liquids as Promoter and Phase‐Separable Reaction Media.
Authors: Garcia‐Suarez Eduardo J. , Khokarale Santosh G. , van Buu Olivier N. , Fehrmann Rasmus , Riisager Anders 
Published: April 2014

AbstractPreformation of the catalytic system by stirring the ionic liquid with Pd(OAc)2 and a ligand in MeOH is important to avoid the formation of Pd‐black and thus to improve the reusability of the catalyst system up to 15 recycle experiments without decrease of the conversion.
ChemInform Abstract: Dual Control of the Selectivity in the Formal Nucleophilic Substitution of Bromocyclopropanes en Route to Densely Functionalized, Chirality Rich Cyclopropyl Derivatives.
Authors: Ryabchuk Pavel , Edwards Andrew , Gerasimchuk Nikolay , Rubina Marina , Rubin Michael 
Published: April 2014

AbstractA highly diastereoselective addition of nucleophiles to in situ generated cyclopropenes is successfully accomplished by using a “dual control” strategy.
ChemInform Abstract: Rhodium‐Catalyzed Cross‐Coupling of Alkenyl Halides with Arylboron Compounds.
Authors: Matsuda Takanori , Suzuki Kentaro , Miura Norio 
Published: April 2014

AbstractThe rhodium(I)‐catalyzed reaction between arylboronic esters and excess 1,2‐dichloroethene selectively affords 2‐chlorovinylarenes (III).
ChemInform Abstract: Hetereogeneous CuII‐Catalyzed Solvent‐Controlled Selective N‐Arylation of Cyclic Amides and Amines with Bromo‐iodoarenes.
Authors: Kundu Debasish , Bhadra Sukalyan , Mukherjee Nirmalya , Sreedhar Bojja , Ranu Brindaban C. 
Published: April 2014

AbstractAn efficient protocol for the N‐arylation of different cyclic amides and amines under convenient conditions is described.
ChemInform Abstract: A Selective Nanocatalyst for an Efficient Ugi Reaction: Magnetically Recoverable Cu(acac)2/NH2‐T/SiO2@Fe3 O4 Nanoparticles.
Authors: Ghavami Monireh , Koohi Maryam , Kassaee Mohammad Zaman 
Published: April 2014

AbstractCu(acac)2 immobilized on the surface of amine‐terminated silica‐coated Fe3O4 nanoparticles appears to be an efficient catalyst for the synthesis of α‐aminoacyl amides (V) (14 examples) Using an Ugi four‐component reaction.
ChemInform Abstract: Aerobic Palladium‐Catalyzed Arylation of Alkenes Using Sodium Sulfinates.
Authors: Taniguchi Nobukazu 
Published: April 2014

AbstractThe combined catalytic system consisting of PdCl2, ammonium hexafluorophosphate and the bisoxazoline ligand catalyzes the arylation reaction of styrenes to give selectively (E)‐1,2‐diarylethylenes in the presence of air.
ChemInform Abstract: Novel Sulfamides and Sulfonamides Incorporating the Tetralin Scaffold as Carbonic Anhydrase and Acetylcholine Esterase Inhibitors.
Authors: Akincioglu Akin , Topal Meryem , Guelcin Ilhami , Goeksu Sueleyman 
Published: April 2014

AbstractNew compounds (V), (VII), (X) and (XI) inhibit human carbonic anhydrase isoenzymes I and II in the low micromolar and submicromolar range and show moderate inhibition capacity toward acetylcholine esterase inhibitors.
ChemInform Abstract: Synthesis of 6′ H‐Spiro(indene‐2,2′‐[1,3]oxathiane)‐1,3,5′‐triones.
Authors: Ukhin Lev Yu. , Belousova Lyudmila V. , Shepelenko Evgenii N. , Morkovnik Anatolii S. 
Published: April 2014

AbstractSpiro compounds (III) and (VII) are prepared from ninhydrin (I).
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling Reaction of Naphthyl Triflate with Indole Boronic Acids Catalyzed by a Recyclable Polymer‐Supported N‐Heterocyclic Carbene—Palladium Complex Catalyst: Synthesis of Naphthalene‐Linked Bis‐heterocycles (IV).
Authors: Reddy P. Aravinda , Reddy A. Babul , Reddy G. Ramachandra , Reddy N. Subbarami 
Published: April 2014

AbstractThe catalyst is reusable several times without significant loss of activity.
ChemInform Abstract: Gold‐Catalyzed Oxazoles Synthesis and Their Relevant Antiproliferative Activities.
Authors: Wu Chao , Liang Zhi‐Wu , Xu Ying‐Ying , He Wei‐Min , Xiang Jian‐Nan 
Published: April 2014

AbstractA series of nine 5‐aryl‐2‐methyloxazoles (III) are synthesized by Au‐catalyzed alkyne oxidation in MeCN.
ChemInform Abstract: 5‐Alkenylthiazoles as In‐Out Dienes in Polar [4 + 2] Cycloaddition Reactions.
Authors: Alajarin Mateo , Cabrera Jose , Sanchez‐Andrada Pilar , Bautista Delia , Pastor Aurelia 
Published: April 2014

AbstractThe thiazoles (IV) undergo regio‐, stereo‐, and site‐selective Diels—Alder reaction with electron‐poor dienophiles to afford various polycyclic thiazole derivatives.
ChemInform Abstract: Chiral Organotin Hydride Catalyzed Enantioselective Radical Cyclization of Aldehydes.
Authors: Shirakawa Seiji , Usui Asuka , Kan S. B. Jennifer , Maruoka Keiji 
Published: April 2014

AbstractAdditionally an example for enantioselective radical reduction of bromide (IX) is given.
ChemInform Abstract: Bis‐(1H‐2‐benzopyran‐1‐one) Derivatives: Synthesis and Antimicrobial Evaluation.
Authors: Koppula Poonam Kumar , Purohit Nalini 
Published: April 2014

AbstractA variety of new bis(benzopyranone) derivatives (V) (13 examples) are synthesized and evaluated for their biological activities.
ChemInform Abstract: Synthesis of New 2,4‐Diaryl‐6‐methyl‐5‐nitropyrimidines as Antibacterial and Antioxidant Agents.
Authors: Sura Mallikarjun Reddy , Peddiahgari Vasu Govardhana Reddy , Bhoomireddy Rajendra Prasad Reddy , Vadde Rama Krishna 
Published: April 2014

AbstractMost of the title compounds (III) show significant activity against Gram‐positive bacteria, S.
ChemInform Abstract: Highly Enantioselective Decarboxylative Mannich Reaction of Malonic Acid Half Oxyesters with Cyclic Trifluoromethyl Ketimines: Synthesis of β‐Amino Esters and anti‐HIV Drug DPC 083.
Authors: Yuan Hai‐Na , Li Shen , Nie Jing , Zheng Yan , Ma Jun‐An 
Published: April 2014

AbstractDPC 083 (X) is prepared in 5 steps starting from the enantiomer of Va.
ChemInform Abstract: The Utility of Carbon Disulfide and Lawesson′s Reagent for Synthesis of Different Fused Heterocycles for Antimicrobial Evaluation.
Authors: Mohamed Nadia R. , Khaireldin Nahed Y. , Fahmy Amin F. , El‐Sayed Ahmed A. 
Published: April 2014

AbstractThe synthesis of a variety of fused pyrimidine and diazaphosphinine derivatives via reactions of 2‐amino‐3‐cyanohexahydroquinolines (I) and related pyrazolopyridines (VII) with CS2 and Lawesson′s reagent, resp., is described.
ChemInform Abstract: Solvent Selection in Synthesis of 4‐(1‐Arylfluoroethoxy)quinazolines and Thienopyrimidines.
Authors: Han Jin , Sundby Eirik , Hoff Baard Helge 
Published: April 2014

AbstractOptimized conditions including acetonitrile as solvent and Cs2CO3 as base allow the efficient nucleophilic aromatic substitution of substrates (I) and (IV) with 1‐aryl‐2‐fluoroethanols as nucleophiles.
ChemInform Abstract: Reactivity of 2‐Methyl‐4H‐3,1‐benzoxazin‐4‐ones and 2‐Methyl‐4H‐pyrido[2,3‐d][1,3]oxazin‐4‐one under Microwave Irradiation Conditions.
Authors: Prousis Kyriakos C. , Tzani Andromachi , Avlonitis Nicolaos , Calogeropoulou Theodora , Detsi Anastasia 
Published: April 2014

AbstractReaction of the title oxazinones (III) with C‐nucleophiles (IV) under microwave irradiation conditions gives fused pyridine derivatives (V) in good yields.
ChemInform Abstract: Thermally Stable 3,6‐Disubstituted 1,2,4,5‐Tetrazines.
Authors: Klapoetke Thomas M. , Preimesser Andreas , Stierstorfer Joerg 
Published: April 2014

AbstractSeveral new 3,6‐disubstituted tetrazine derivatives are synthesized by nucleophilic substitution reactions of bis(pyrazolyl)tetrazine (I) or chlorotriazine derivatives.
ChemInform Abstract: Hard and Soft Electrophilic and Nucleophilic Dissymmetry of α‐Oxoketenedithioacetals and p‐Nitro‐o‐phenylenediamine Exploited to Achieve the Regioselectivity in the Synthesis of 2‐Thiomethyl Ether Substituted Isomer of the Privileged Nucleus of 1,5‐Benzodiazepines over to Its 4‐Substituted Isomers.
Authors: Chaudhary Priyanka , Gupta Aarti , Devi Pragati , Kishore Dharma 
Published: April 2014

AbstractA regioselective way to synthesize 2‐thiomethyl substituted isomers of 1,5‐benzodiazepines is presented.