bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence to psychiatric medications and diagnosis
Authors: González Navarro C. , Bilbao Idarraga A. , Alonso Salas I. , Morado San segundo L. , López Fariña A. , López Puentes U. , Samsó Martínez B. , Lopez Brokate R. F. , Ruiz de Azua Aspizua T. , Garnica de Cos E. M. , Ortega Pozas U. 
Published: July 2024

Introduction
Patients with mental disorders frequently become non-adherent during their long term prescribed treatment. This situation frequently triggers clinical worsening and hospital admission. Therefore, non-adherence may result in poorer long term clinical outcomes and has economic implications for health-care providers (Carlos De las Cuevas et al. Neuropsychopharmacol Hung 2021; 23(4):347-362).

Objectives
- To describe the adherence to oral and long acting injectable treatment in the sample of patients that were admitted to the short stay hospital unit during the period of study.
- To describe the adherence to treatment amongst psychiatric diagnosis in the sample of study.

Methods
It was a retrospective observational study with a duration of three months. Data was collected from all patients admitted to the short stay hospital unit during the period of study and there were no specific exclusion criteria. Descriptive statistics were performed. To assess the adherence to pharmachological treatment the patient report, the family report and the pharmacy dispensation according to the existent informatic prescription platform was considered. Regarding the long acting injectable treatment the formulary of administration in the clinical history was checked.

Results
During the period of study 172 patients were admitted to the short stay hospital unit. Of those, 146 patients had a previous pharmacologic prescription. Data of treatment was not possible to obtain in 7 patients. In the sample of study, 83.5% were on oral and 16.5% on long acting injectable treatment. The general adherence to treatment in the sample was 61.87%. In the oral treatment group the adherence was 58.4% and in the long acting injectable treatment group was 65.2%.
Amongst the different psychiatric diagnoses the outcomes of adherence to treatment were: 60.4% in schizophrenia and related psychosis, 62.5% in bipolar disorder, 78.6% in depression, 58.3% in personality disorders and 62% in addictive disorders.

Conclusions
In our descriptive study adherence to treatment was higher in the long acting injectable treatment group, agreeing with the existent scientific literature.
The results of adherence for schizophrenia and bipolar disorder are similar to the ones found in scientific literature but differ from the ones for depression, being higher in our sample (Judit Lazary et al. Neuropsychopharmacol Hung 2021;23(4): 347-362). Moreover, in scientific literature it is found a similar prevalence of adherence across diagnosis (for schizophrenia, bipolar disorder and depression) whereas in our sample patients with depression showed a different and higher adherence to treatment (Judit Lazary et al. Neuropsychopharmacol Hung 2021;23(4): 347-362). In our sample, patients with personality disorders had the lowest adherence to treatment.

Disclosure of Interest
None Declared
Knockout Transporter Cell Lines to Assess Substrate Potential Towards Efflux Transporters
Authors: Volpe Donna A. 
Published: July 2024

AbstractP-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance transporter 2 (MRP2) are efflux transporters involved in the absorption, excretion, and distribution of drugs. Bidirectional cell assays are recognized models for evaluating the potential of new drugs as substrates or inhibitors of efflux transporters. However, the assays are complicated by a lack of selective substrates and/or inhibitors, as well simultaneous expression of several efflux transporters in cell lines used in efflux models. This project aims to evaluate an in vitro efflux cell assay employing model substrates and inhibitors of P-gp, BCRP and MRP2 with knockout (KO) cell lines. The efflux ratios (ER) of P-gp (digoxin, paclitaxel), BCRP (prazosin, rosuvastatin), MRP2 (etoposide, olmesartan) and mixed (methotrexate, mitoxantrone) substrates were determined in wild-type C2BBe1 and KO cells. For digoxin and paclitaxel, the ER decreased to less than 2 in the cell lines lacking P-gp expression. The ER decreased to less than 3 for prazosin and less than 2 for rosuvastatin in the cell lines lacking BCRP expression. For etoposide and olmesartan, the ER decreased to less than 2 in the cell lines lacking MRP2 expression. The ER of methotrexate and mitoxantrone decreased in single- and double-KO cells without BCRP and MRP2 expression. These results show that KO cell lines have the potential to better interpret complex drug-transporter interactions without depending upon multi-targeted inhibitors or overlapping substrates. For drugs that are substrates of multiple transporters, the single- and double-KO cells may be used to assess their affinities for the different transporters.
Graphical Abstract
Improving the Risk Prediction of the 2015 ATA Recurrence Risk Stratification in Papillary Thyroid Cancer
Authors: Wang Hongxi , Li Qianrui , Tian Tian , Liu Bin , Tian Rong 
Published: July 2024

Abstract

Background
Various prognostic factors are expected to refine the American Thyroid Association recurrence risk stratification for patients with papillary thyroid cancer (PTC). However, it remains unclear to what extent integrating these factors improves patient treatment decision-making.

Methods
We developed 2 predictive models for structural incomplete response (SIR) at the 1-year follow-up visit, based on comprehensive clinical data from a retrospective cohort of 2539 patients. Model 1 included the recurrence risk stratification and lymph node features (ie, number and ratio of metastatic lymph nodes, N stage). Model 2 further incorporated preablation stimulated thyroglobulin (s-Tg). An independent cohort of 746 patients was used for validation analysis. We assessed the models’ predictive performance compared to the recurrence risk stratification using the integrated discrimination improvement (IDI) and the continuous net reclassification improvement (NRI). The clinical utility of the models was evaluated using decision curve analysis.

Results
Both model 1 and model 2 outperformed the recurrence risk stratification in predicting SIR, with improved correct classification rates (model 1: IDI = 0.02, event NRI = 42.31%; model 2: IDI = 0.07, event NRI = 53.54%). The decision curves indicated that both models provided greater benefits over the risk stratification system in clinical decision-making. In the validation set, model 2 maintained similar performance while model 1 did not significantly improve correct reclassification.

Conclusion
The inclusion of lymph node features and s-Tg showed potential to enhance the predictive accuracy and clinical utility of the existing risk stratification system for PTC patients.
Potential Differences in Psychedelic Actions Based on Biological Sex
Authors: Shadani Sheida , Conn Kyna , Andrews Zane B , Foldi Claire J 
Published: July 2024

Abstract
The resurgence of interest in psychedelics as treatments for psychiatric disorders necessitates a better understanding of potential sex differences in response to these substances. Sex as a biological variable (SABV) has been historically neglected in medical research, posing limits to our understanding of treatment efficacy. Human studies have provided insights into the efficacy of psychedelics across various diagnoses and aspects of cognition, yet sex-specific effects remain unclear, making it difficult to draw strong conclusions about sex-dependent differences in response to psychedelic treatments. Compounding this further, animal studies used to understand biological mechanisms of psychedelics predominantly use one sex and present mixed neurobiological and behavioral outcomes. Studies that do include both sexes often do not investigate sex differences further, which may hinder the translation of findings to the clinic. In reviewing sex differences in responses to psychedelics, we will highlight the direct interaction between estrogen (the most extensively studied steroid hormone) and the serotonin system (central to the mechanism of action of psychedelics), and the potential that estrogen-serotonin interactions may influence the efficacy of psychedelics in female participants. Estrogen influences serotonin neurotransmission by affecting its synthesis and release, as well as modulating the sensitivity and responsiveness of serotonin receptor subtypes in the brain. This could potentially influence the efficacy of psychedelics in females by modifying their therapeutic efficacy across menstrual cycles and developmental stages. Investigating this interaction in the context of psychedelic research could aid in the advancement of therapeutic outcomes, especially for conditions with sex-specific prevalence.
PHILOSOPHICAL AND ETHICAL METHODOLOGY OF L. I. PETRAZYSKI’S LAW THEORY
Authors: Erokhin Aleksey K. 
Published: July 2024

The article is devoted to the large-scale L. I. Petrazyski’s theory of law, which is filled with new ideas that introduced into methodology, psychology and philosophy of law.
The article is targeted to explore the mental structure of consciousness developed by Petrazyski, which is adaptable to a wide range of legal norms and subjective standards for assessing the content of legal experience.
Methodology and methods. The dialectical method of discussion was used, supplemented by the deductive method and the method of critical analysis.
Results. According to Petrazyski, law itself contains a dichotomy of individual imperative and external instructions for fulfilling duties. Understanding of internal imperative is formed in the mind under the influence of legal experience gained in everyday life. On this basis, an intuitive right is formed that determines a person’s attitude to social activities and personal behavior. The idea of ​​intuitive law runs through all of Petrazycki’s works, which gives him the opportunity to build the concept of a historically inextricable connection between morality and law, resulting in the correct formation of legal norms, changes in social life, and movement towards the common good and justice. It is concluded that Petrazyski’s main contribution to the theory and philosophy of law lies in his firm belief in the unity of law, morality and psychology, as a distinctive characteristic of intuitive law from positive law.
Practical implication. The results of the work can be used for further research into Petrazyski’s philosophical and legal ideas of law.
Rank-One Boolean Tensor Factorization and the Multilinear Polytope
Authors: Del Pia Alberto , Khajavirad Aida 
Published: July 2024

We consider the NP-hard problem of finding the closest rank-one binary tensor to a given binary tensor, which we refer to as the rank-one Boolean tensor factorization (BTF) problem. This optimization problem can be used to recover a planted rank-one tensor from noisy observations. We formulate rank-one BTF as the problem of minimizing a linear function over a highly structured multilinear set. Leveraging on our prior results regarding the facial structure of multilinear polytopes, we propose novel linear programming relaxations for rank-one BTF. We then establish deterministic sufficient conditions under which our proposed linear programs recover a planted rank-one tensor. To analyze the effectiveness of these deterministic conditions, we consider a semirandom model for the noisy tensor and obtain high probability recovery guarantees for the linear programs. Our theoretical results as well as numerical simulations indicate that certain facets of the multilinear polytope significantly improve the recovery properties of linear programming relaxations for rank-one BTF. Funding: A. Del Pia is partially funded by the Air Force Office of Scientific Research [Grant FA9550-23-1-0433]. A. Khajavirad is partially funded by the Air Force Office of Scientific Research [Grant FA9550-23-1-0123].
Mutualistic relationship between Baird´s tapir Tapirus bairdii and brown basilisk Basiliscus basiliscus at Corcovado National Park, Costa Rica
Authors: Paniagua Dionisio , Mora José Manuel 
Published: July 2024

Algunas relaciones simbióticas, como el mutualismo, benefician a los individuos de las especies involucradas. Aunque existen registros de animales que se alimentan de organismos hematófagos que infestan a otros vertebrados, los casos de reptiles que se alimentan sobre mamíferos son escasos. Aquí reportamos el caso del cherepo, Basiliscus basiliscus alimentándose sobre la danta, Tapirus bairdii, en Costa Rica. Las observaciones se llevaron a cabo en el Parque Nacional Corcovado, Costa Rica donde uno de los autores (D. Paniagua) realiza excursiones con grupos de turistas. Durante tales excursiones, se ha observado a basiliscos en la espalda de tapires cazando tábanos (Tabanidae) que aterrizan en ellos para alimentarse de su sangre. Se obtuvieron al menos 10 observaciones de este comportamiento entre basiliscos y tapires. Estos casos se observaron con mayor frecuencia en días calurosos y cuando hay suficiente agua en los charcos u otras fuentes. Cuando los tapires descansan en lugares secos, no se ha observado la presencia de basiliscos. Este comportamiento tiene como objetivo alimentarse de tábanos hembra, que constantemente acosan a los tapires intentando posarse y alimentarse de su sangre. El cherepo obtiene alimento y ayuda a los tapires al reducir las picaduras dolorosas de los tábanos y la propagación potencial de enfermedades. Este comportamiento mutualista no había sido descrito anteriormente para ninguna de estas 2 especies.
New record of Cryptotis mayensis in the Gulf of México coastal plains
Authors: Pineda-Vásquez Alejandra B. , Jiménez-Prudencio Marina E. , González-Morales Janier H. , Velázquez-Damas José A. , Delfín-Alfonso Christian A. , Hidalgo-Mihart Mircea G. 
Published: July 2024

La musaraña de orejas pequeñas de Yucatán, Cryptotis mayensis (Merriam, 1901), es una musaraña poco conocida que habita en tierras bajas cubiertas por bosques tropicales en la Península de Yucatán en México, así como en Guatemala y Belice. Como parte de un estudio de evaluación de poblaciones de roedores en plantaciones de palma de aceite (Elaeis guineensis), se capturó un ejemplar de C. mayensis al interior de una plantación joven de palma que está localizada en la Planicie costera del Golfo de México en los límites de Tabasco y Campeche. El registro de la especie se encuentra a 60 km al norte de los registros más cercanos de la especie, lo que extiende el área de distribución de ésta; además, debido a que el ejemplar fue capturado en un monocultivo rodeado de pastizales para la ganadería, podría indicar que C. mayensis tiene capacidad de habitar en sitios con alta perturbación.
Presence of Neotropical otter, Lontra longicaudis annectens, on Champotón River Banks, Campeche
Authors: López-Ruiz Javier I. , Delgado-Estrella Alberto , Vázquez-Maldonado Laura E. , Poot-Delgado Carlos A. 
Published: July 2024

Derivado del extenso territorio en el que habita la nutria neotropical, además de conocer la importancia ecológica de esta especie, se realizó un monitoreo durante un año en la ribera del río Champotón después de 22 años del único registro documentado en el área de estudio con la finalidad de confirmar la presencia de la nutria neotropical Lontra longicaudis annectens. Durante 3 temporadas climáticas (nortes de 2019, secas y lluvias de 2020) se realizaron recorridos a bordo de una embarcación a lo largo de los 30 km navegables del río Champotón. Se colectaron evidencias directas e indirectas de la presencia de nutrias debidamente georreferenciadas. Adicionalmente se registró la temperatura y la salinidad del agua de estos sitios. La temperatura registrada fue de 30 ± 3 °C y la salinidad de 0-8 ppm. Se recolectaron 33 evidencias indirectas tales como comederos y heces: 22 en la temporada de nortes (2019), 5 en la temporada de secas y 6 en temporada de lluvias (2020), además de un avistamiento en la temporada de nortes (2019). Se analizaron las evidencias indirectas, confirmando los hábitos de alimentación basados en crustáceos y peces de la zona. Las condiciones ambientales, de alimentación, flora y fauna del río Champotón, fueron propicias para confirmar la presencia de L. l. annectens, a poco más de 2 décadas de su primer registro en el área de estudio; sin embargo, se debe poner atención a las afectaciones antrópicas
First record of melanism in the northern palm squirrel Funambulus pennantii in Delhi, India
Authors: Puri Kanchan , Joshi Ritesh 
Published: July 2024

El melanismo es un fenómeno poco común en los animales y es causado por un desarrollo excesivo de pigmentos oscuros (melanina) que produce un oscurecimiento de la piel y el pelo de los animales. En esta nota, informamos e ilustramos una observación de melanismo en una ardilla de palma del norte, Funambulus pennantii, en un parque urbano, Siri Fort Park, en el Territorio de la Capital Nacional de Delhi, al norte de la India. Durante los estudios de campo se observó una ardilla de las palmeras del norte con melanismo. El individuo era parcialmente negro, con cabeza, cuello, orejas y extremidades anteriores negruzcas, mientras que, la parte trasera del cuerpo y la cola tenían un color normal. Debido a que no se han reportado casos de melanismo en la ardilla de la palma del norte en la región, esta nota constituye el primer registro de la presencia de la ardilla de la palma de cinco rayas con melanismo en el Territorio de la Unión de Delhi. Lo anterior abrirá nuevas dimensiones en la historia natural de la especie. Se necesitan más estudios que ayuden a comprender este fenómeno raro en la especie, y las implicaciones ecológicas y fisiológicas, como la supervivencia, de las poblaciones de las especies.
New record of the Neotropical otter (Lontra longicaudis) in the forests of the Río Sapo basin, El Salvador
Authors: Pocasangre-Orellana Xochilt , Álvarez Francisco S. 
Published: July 2024

La nutria neotropical Lontra longicaudis es una especie poco estudiada en El Salvador y nuestro conocimiento sobre la especie es escaso. El objetivo de esta investigación fue registrar la presencia ocasional de L. longicaudis en la cuenca de Río Sapo, El Salvador. El trabajo de campo se llevó a cabo entre agosto y septiembre de 2022 usando 20 cámaras trampa en la cuenca de Río Sapo. Reportamos las primeras fotografías y video de 2 individuos de L. longicaudis dentro del bosque en la cuenca de Río Sapo. Confirmamos la ocurrencia de L. longicaudis en la cuenca de Río Sapo utilizando el bosque, mostrando la importancia de considerar bosques adyacentes a cuerpos de agua para el estudio y monitoreo de esta especie.
Post-discharge surgical site infection surveillance using patient smartphones: a single-centre experience in cardiac surgery
Authors: Rochon Melissa , Tanner Judith , Cariaga Karen , Ingusan Sean Derick , Jawarchan Angila , Morais Carlos , Odattil Bella , Dizon Ron 
Published: July 2024

Background/Aims Surgical site infections following cardiac surgery pose significant risks and financial burdens to both patients and healthcare systems. This study aimed to explore the implementation and outcomes of a novel surgical wound monitoring system using patient smartphones for post-discharge surveillance. Methods The study was conducted at a London-based cardiothoracic tertiary referral centre, where 1358 patients undergoing cardiac surgery between January 2021 and March 2023 were enrolled onto the surgical wound monitoring system. Data were collected from the National Cardiac Audit Programme dataset, the monitoring syste and Hospital Episode Statistics data. Comparisons between patients who did or did not respond to surveillance requests were performed. A nested confirmatory analysis assessed antibiotics reported by patients through the digital route compared with antibiotics given by GPs or in outpatients. Results The overall response rate for surgical wound monitoring using patient smartphones was 86.6%. Patients who were female, from areas of higher deprivation and lived closer to the hospital were less likely to engage with surgical wound monitoring. Although not statistically significant, the current study suggests that patients with surgical site infections who used smartphones for surgical wound monitoring were less likely to be re-admitted or have further surgery and had shorter readmission stays. The accuracy of antibiotic use for surgical site infections using the surgical wound monitoring system was 96.5%. Conclusions This study underscores the potential of digital technologies, particularly smartphones, in efficient and accurate post-surgical monitoring. The findings suggest that the use of digital monitoring systems may improve patient outcomes, with potential for wider system-level benefits.
Relaxation intervention to improve diabetic foot ulcer healing: protocol for a pilot study with a nested qualitative study
Authors: Ferreira Gabriela , Carvalho André , Pereira M Graça 
Published: July 2024

Objective: A mixed-methods approach nested in a pilot three-arm randomised controlled trial (RCT) was conducted to evaluate the feasibility and acceptability of an intervention of progressive muscle relaxation with guided imagery (experimental group) compared to a neutral guided imagery placebo (active control group) and a group that did not receive any psychological intervention (passive control group). The purpose was to inform a future definitive RCT that will test its effectiveness. Qualitatively, this study examined patients and health professionals' perspectives regarding the relaxation intervention, in order to assess the acceptability and applicability of relaxation as an adjuvant therapy. Method: Participants must have had a diagnosis of diabetes and diabetic foot disease; one or two active hard-to-heal ulcers at the time of the assessment; and clinical levels of stress or anxiety or depression. Participants were randomised and assessed at three timepoints after the first hospital consultation for hard-to-heal diabetic foot ulcer (DFU). Results: Rates of eligibility, recruitment, refusal, adherence to study protocol, participation in follow-up and dropout, and patients' satisfaction with the relaxation intervention were assessed as primary outcomes. Secondary outcomes were DFU healing; patients' DFU-related quality of life; physical and mental quality of life; perceived stress; emotional distress; adherence to DFU care; perceptions of DFU; as well as arterial systolic/diastolic pressure and heart rate. Conclusion: The results of this pilot study contributed to clarification and better elucidation of the benefits of relaxation techniques regarding patients' HRQoL and DFU healing. Declaration of interest: Funding: This study was conducted at the Psychology Research Centre (CIPsi/UM) School of Psychology, University of Minho, Portugal and supported by the Foundation for Science and Technology (FCT) through the Portuguese State Budget (UIDB/01662/2020) and by a PhD fellowship from FCT assigned to GF (SFRH/BD/131780/2017) and an FCT grant (PTDC/PSI-GER/28163/2017) assigned to MGP. The authors have no conflicts of interest to declare.