bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human-water interactions associated to cercarial emergence pattern and their influences on urinary schistosomiasis transmission in two endemic areas in Mali
Authors: Sidibé Bakary , Agniwo Privat , Diakité Assitan , Savassi Boris Agossou Eyaton-olodji Sègnito , Doumbo Safiatou Niaré , Akplogan Ahristode , Guindo Hassim , Ibikounlé Moudachirou , Dembélé Laurent , Djimde Abdoulaye , Boissier Jérôme , Dabo Abdoulaye 
Published: August 2024

Abstract
Background
Mali is known to be a schistosomiasis-endemic country with a limited supply of clean water. This has forced many communities to rely on open freshwater bodies for many human-water contact (HWC) activities. However, the relationship between contact with these water systems and the level of schistosome infection is currently receiving limited attention. This study assessed human-water interactions including cercarial emergence pattern and their influences on urinary schistosomiasis transmission in two communities in the Kayes district of Mali.

Methods
We carried out a parasitological study first in children in September 2021, then a cross-sectional study of quantitative observations of human-water contact activities in the population, and finally a study of snail infectivity at contact points in September 2022. The study took place in two communities, Fangouné Bamanan and Diakalèl in the Kayes region of western Mali. The chronobiological study focused on cercarial release from naturally infected snails. Released cercariae were molecularly genotyped by targeting the cox1 region, and the ITS and 18S ribosmal DNA gene (18S rDNA) regions of the DNA. Links between sociodemographic parameters, human water-contact points and hematuria were established using multivariate statistical analysis or the logistic regression model.

Results
The main factor predisposing the 97 participants to water contact was domestic activity (62.9%). Of the 378 snails collected at 14 sampling sites, 27 (7.1%) excreted schistosome cercariae, with 15.0% (19/126) at Fangouné Bamanan and 3.3% (8/252) at Diakalel. The release of Schistosoma cercariae shows three different patterns in Fangouné Bamanan: (i) an early release peak (6:00–8:00 AM), (ii) a mid-day release peak (10:00 AM–12:00 PM) and (iii) a double peak: (6:00–8:00 AM) and (6:00–8:00 PM) cercariae release; and two release patterns in Diakalel: early release (6:00–8:00 AM) and (ii) mid-day release (12:00–2:00 PM). All cercariae released during early diurnal (6:00–8:00 AM) or nocturnal emission patterns (6:00–8:00 PM) were hybrids parasite having an cox1 S. bovis or S. curassoni associated with an ITS and 18S rDNA of S. haematobium while the cercariae released during diurnal, or mid-day patterns (8:00 AM–6:00 PM) were pure S. haematobium.

Conclusions
Our study showed that domestic activity is the main source of exposure in the Kayes region. Two and three cercariae emission patterns were observed at Diakalel and Fangouné Bamanan respectively. These results suggest that the parasite adapts to the human-water contact period in order to increase its infectivity.

Graphical Abstract
Peer Review in Radiation Oncology: Where Does the Middle East, North Africa, and Türkiye Region Stand?
Authors: Abutaha Shatha , Mula-Hussain Layth , ElHaddad Mostafa , Sami Sara , Ammar Khawla , Dahbi Zineb , Jabbour Caroline , Selek Ugur , Abu-Hijlih Ramiz , Al-Ibraheem Akram , Abuhijla Fawzi , Abbasi Ahmed , Bushehri Ahmad , Alotain Ibrahim , Aldehaim Mohammed , Alghamdi Majed , Abu-Gheida Ibrahim , Pervez Nadeem , Youssef Bassem , Alrashidi Saad , El-sheshtawy Wael , Hosni Ali , Mohamad Issa 
Published: August 2024

PURPOSE This study aims to assess the status of radiation oncology peer review procedures across the Middle East, North Africa, and Türkiye (MENAT) region. METHODS A cross-sectional electronic survey was conducted among radiotherapy centers in the MENAT region in March 2024. It assessed peer review practices, departmental demographics, perceived importance of peer review, and potential barriers. RESULTS Data from 177 radiation oncology centers revealed varying peer review implementation across the MENAT region. Egypt had the highest participation (16.4%) among all responders. Most centers (31%) treated 500-1,000 cases annually. The majority (77.4%) implemented peer review, with varying levels between countries and across different centers. Advanced radiotherapy techniques significantly correlated with implementation of peer review ( P < .05). Peer review meetings were mostly scheduled on a weekly basis (46%) and organized by radiation oncologists (84.7%). Target volume contouring (89%) and radiotherapy prescription (82%) were frequently peer-reviewed. Respondents with peer review at their institutions significantly valued peer review for education, adherence to guidelines, improving planning protocols, and reducing variation in practice institutions without peer review ( P < .05). The most frequently reported barriers to peer review were having a high number of patients (56%) and shortage of time (54%). CONCLUSION Peer review is essential for improving the quality of practice in radiation oncology. Despite some discrepancies, numerous obstacles, and challenges in implementation, it is instrumental in the improvement of patient care in most centers throughout the region. Raising awareness among radiation oncologists about the importance of peer review is paramount to lead to better outcomes.
Patient Experience of Complex Genomic Sequencing Exploring Patient Preference, Barriers, and Enablers for Delivery
Authors: Smith Kortnye , O'Haire Sophie , Markman Benjamin , Gan Hui K. , O'Byrne Kenneth , Millward Michael , Tran Ben , Solomon Benjamin J. , Scott Clare , Kee Damien , McArthur Grant , Fellowes Andrew , Khoung-Quang Dong Anh K. , Ekert Paul , James Paul , Xu Huiling , Martyn Melissa , Lynch Elly , Weerasuriya Rona , Gaff Clara , Fox Stephen B. , Desai Jayesh 
Published: August 2024

PURPOSE Despite increasing evidence of benefit supporting complex genomic sequencing (CGS) in personalizing cancer therapy, its widespread uptake remains limited. METHODS This mixed-methods, prospective cross-institutional demonstration study was designed to evaluate implementation of CGS in the care of patients with advanced cancer. DNA sequencing was undertaken on formalin-fixed paraffin-embedded tumor and matched blood was completed with the Peter MacCallum Cancer Centre Comprehensive Cancer Panel; 391 genes via central laboratory. Oncologists performed consent and result delivery. Patients completed pre- and post-test surveys, including validated and study-specific questions and, if eligible, semistructured interviews. Qualitative interviews were undertaken with study clinicians to evaluate processes. RESULTS One hundred ninety-nine (63%) had ≥1 finding with the potential to affect management, including 172 (55%) whose finding could affect their treatment options, 25 (8%) whose test led to the resolution of diagnostic ambiguity, and 49 (16%) with a pathogenic germline variant. In 6-month follow-up, 50 (16%) participants had their subsequent therapy changed on the basis of their CGS results. Two hundred ninety-three (88% of adult patients) completed surveys at three time points. At consent, patients cited multifaceted value in testing, showed good understanding of basic concepts, but most (69%) overestimated the likelihood of result-led change. Post-test patients remained consistently satisfied with accessing CGS. 21% struggled with understanding results but there were low levels of decisional regret after participation (89% had nil/mild regret). Clinicians cited collaboration and communication as critical to delivery. CONCLUSION Patients undergoing CGS are generally satisfied and place value on its use beyond potential therapeutic benefit. Our results suggest that to improve test utility and delivery of CGS with value to patients and investing institutions, focus must be placed on addressing the additional barriers to its wider implications including efforts to improve process efficiencies, clinician genomic literacy, and decision-making support.
Application of Topographical Anatomy of the Trochlear Nerve in Transtentorial Approaches: An Anatomic Study
Authors: Peto Ivo , Pressman Elliot , Piper Keaton , Flores-Milan Gabriel , Ryan Casey , Vakharia Kunal , van Loveren Harry , Agazzi Siviero 
Published: August 2024

BACKGROUND AND OBJECTIVES:
Transection of the free edge of tentorium (FET) might be necessary when approaching cavernous sinus lesions, clip placement in certain posterior communicating artery aneurysms, or during transpetrosal and retrosigmoid transtentorial approaches. No anatomic study has investigated the relationship of the trochlear and oculomotor nerve and FET in an attempt to identify a safe zone for such maneuver.

METHODS:
Ten embalmed specimens (20 sides) were studied and the following morphometric measurements were taken using digital microcalipers: trochlear (TP) to oculomotor porus (OP), length of the intratentorial segment of cranial nerve (CN) IV, nerve free FET, and distance along the oculomotor (CN III) from its OP to CN III/trochlear (CN IV) crossing and angle between the long-axis petrous ridge and TP (petrotrochlear angle).

RESULTS:
The CN IV pierced the deep layer of the FET in all cases at a mean distance 8.11 mm (4.43-11.33) posterior to the OP, measured along the FET. CN IV continued within the tentorial edge for a mean of 6.17 mm (3.18-11.33) before entering the cavernous sinus at a mean distance of 1.9 mm (0-5.46 mm) from the posterior-most aspect of the OP. A nerve-free portion of FET was 1.93 mm (mean) (0-5.46). No nerve-free FET segment (<1 mm) was observed in 4 sides (20%), and a nerve-free FET segment <2.00 mm was seen in 55% of cases. The mean distance from OP to the CN III/IV crossing was 10.17 mm (1.00-15.57). The mean petrotrochlear angle was 164.49° (140.01-183.85), and >175° in 4 specimens (20%).

CONCLUSION:
Our data confirm presence of the intratentorial segment of CN IV. Transection of the FET carries the lowest risk of CN IV injury if performed < 2 mm or >10 mm posterior to the OP, or posterior to intersection of the FET and a virtual extension of a petrous ridge.
Robust Online Selection with Uncertain Offer Acceptance
Authors: Perez-Salazar Sebastian , Singh Mohit , Toriello Alejandro 
Published: August 2024

Online advertising has motivated interest in online selection problems. Displaying ads to the right users benefits both the platform (e.g., via pay-per-click) and the advertisers (by increasing their reach). In practice, not all users click on displayed ads, while the platform’s algorithm may miss the users most disposed to do so. This mismatch decreases the platform’s revenue and the advertiser’s chances to reach the right customers. With this motivation, we propose a secretary problem where a candidate may or may not accept an offer according to a known probability p. Because we do not know the top candidate willing to accept an offer, the goal is to maximize a robust objective defined as the minimum over integers k of the probability of choosing one of the top k candidates, given that one of these candidates will accept an offer. Using Markov decision process theory, we derive a linear program for this max-min objective whose solution encodes an optimal policy. The derivation may be of independent interest, as it is generalizable and can be used to obtain linear programs for many online selection models. We further relax this linear program into an infinite counterpart, which we use to provide bounds for the objective and closed-form policies. For [Formula: see text], an optimal policy is a simple threshold rule that observes the first [Formula: see text] fraction of candidates and subsequently makes offers to the best candidate observed so far. Funding: Financial support from the U.S. National Science Foundation [Grants CCF-2106444, CCF-1910423, and CMMI 1552479] is gratefully acknowledged.
João Zanetic e Gaston Bachelard
Authors: Lima Maria da Conceição de Almeida Barbosa , Faur de Castro Catarino Giselle 
Published: August 2024

Nesse escrito especial nosso propósito é homenagear João Zanetic, mesmo sem alcançar sua grandiosidade e sua generosidade. Professor e pesquisador do Instituto de Física da Universidade de São Paulo por vários anos, dentre muitas de suas propostas para a área de Ensino de Física, foi o precursor da pesquisa de Física e Arte, através da Literatura. Chamamos a este texto Gaston Bachelard por ter sido, senão o referencial preferido por Zanetic, com certeza, um deles. Fica aqui, portanto, nossa homenagem a um grande professor de todos nós.
Is the fire even bigger? Burnout in 800 medical and nursing students in a low middle income country
Authors: Mufarrih Syed Hamza , Qureshi Nada Qaisar , Hashmi Syeda Amrah , Syed Abbas Raza , Anwar Muhammad Zohaib , Lakdawala Riaz Hussain , Asad Nargis , Haider Adil , Noordin Shahryar 
Published: August 2024

Background
Burnout, characterized by emotional exhaustion (EX), depersonalization (DP), and a reduced sense of personal efficacy (PF) among medical and nursing students can lead to suicidal ideation, lack of empathy, and dropouts. Previous studies have used over-simplified definitions of burnout that fail to capture its complexity. We describe the prevalence of burnout profiles and its risk factors among medical and nursing students.

Methods
A cross sectional study was conducted at a tertiary care University Hospital in Pakistan. The Maslach Burnout Inventory (MBI) survey was disseminated via SurveyMonkey over a period of 4 months (November 2019 to February 2020) to 482 Medical and 441 nursing students. The MBI tool measures the dimensions of EX, DP, and PF to describe seven burnout profiles. Multivariable regression was used to identify predictors of burnout.

Results
The response rate was 92% in nursing and 87.3% in medical students. The prevalence of burnout in medical and nursing students was 16.9% and 6.7% respectively (p<0.001), with 55.7% (n = 427) suffering from at least one burnout profile. Only 32.5% (n = 250) students felt engaged, (42.3% medical, 22.7% nursing students, p<0.001). The most common profile was ineffective (32.5%, n = 250), characterized by a reduced sense of personal efficacy (35.6% medical, 29.4% nursing students; p = 0.065). Medical students were at higher risk of burnout compared to nursing students (OR = 2.49 [1.42, 4.38]; p<0.001) with highest risk observed in year 4 (OR = 2.47 [1.02, 5.99]; p = 0.046). Other risk factors for burnout included occasional drug use (OR = 1.83 [1.21, 8.49]; p = 0.017) and living in a hostel (OR = 1.64 [1.01,2.67]; p = 0.233).

Conclusion and relevance
Two-thirds of our participants experienced at least one dimension of burnout with the highest prevalence of a reduced sense of PF. Drivers of burnout unique to a lower-middle-income country need to be understood for effective interventions. Faculty training on principles of student evaluation and feedback may be beneficial.
Validation of an ultra-short global quality of life scale in a large population-based health survey
Authors: Vederhus John-Kåre , Timko Christine , Birkeland Bente , Haugland Siri Håvås , Gabrielsen Karin Berle 
Published: August 2024

Introduction
Quality of life (QoL) assessment is essential in health-related research and clinical settings, offering insights into individuals’ well-being and functioning. This study validated the Essential QoL-3 (EQoL-3), an ultra-short scale assessing essential dimensions of QoL, for use in epidemiological research and clinical settings.

Methods
Data from a 2021 national survey in Norway (N = 17,487) were used. Three items on the EQoL-3 assess life satisfaction, happiness, and meaningfulness on a 0–10 scale. Discriminant validity was assessed by comparing the EQoL-3 with the Satisfaction with Life Scale (SWLS) and by examining latent mean differences between individuals with adverse life experiences (ALE+) and those without such experiences (ALE-). Convergent validity was evaluated through latent regression analyses comparing the EQoL-3 with a perceived mastery scale and a mental distress scale.

Results
The discriminant validity of the EQoL-3 was less than optimal when compared with the SWLS. Nonetheless, a multigroup confirmatory factor analysis revealed that the EQoL-3 score was 1.42 (95% CI = 1.33–1.50, p < 0.001) lower in the ALE+ group compared to the ALE- group, providing support for discriminant validity. Convergent validity was established with a positive association between EQoL-3 and mastery (β = 1.75, 95% CI = 1.70–1.80, p < 0.001) and a negative association between the EQoL-3 and mental distress (β = -2.64, 95% CI = -2.71/-2.59, p < 0.001).

Conclusions
The EQoL-3 is a reliable measure of QoL. Its streamlined nature facilitates quick administration, making it a valuable tool for clinicians and researchers in diverse settings. Its inclusion of the eudaimonic dimension, as well as its exclusion of health items in the measure itself, distinguishes it from traditional HQoL measures, making it suitable for mental health and substance use disorder research.
Spatial distribution and determinants of physical intimate partner violence among women in Kenya: Evidence from the 2022 Kenya Demographic and Health Survey
Authors: Okyere Joshua , Ayebeng Castro , Boateng Ebenezer N. K. , Assie Rebecca A. A. , Odoi Amanda , Dzirassah King-David , Ankomahene Bright , Dickson Kwamena Sekyi 
Published: August 2024

Background
Despite global, regional, and national efforts to address intimate partner violence (IPV), physical IPV persists as a significant challenge in Kenya. This study employs geospatial analysis to examine the spatial distribution and determinants of physical intimate partner violence among women, aiming to inform targeted interventions and policies.

Methods
The study used a secondary analysis of a cross-sectional study design based on the 2022 Kenya demographic and health survey. Analyses were conducted using Stata version 17.0 and ArcMap version 10.8. Spatial autocorrelation and hotspot assessment were conducted in the geospatial analysis, while a multilevel logistic regression model was used to examine determinants of physical violence among reproductive-aged women.

Results
The study found 28.8% (10,477) of the surveyed women reported experiencing physical intimate partner violence. The spatial analysis identified significant clusters in the southwest and central regions, with women in sub-counties like Chepaluugu, Konion, Sotik, Bumula, and Metayos among others experiencing more violence. Conversely, women in areas in the North East and South East corners such as Kisauni, Tarabaj, Waijir North, Lafey, and Mandera North and South among others showed little or no physical intimate partner violence. Multivariable logistic regression identified age, education, wealth index, partner domineering indicators, and justification of wife beating to be associated with physical intimate partner violence. Higher education and wealth were associated with lower violence odds, while partner domineering indicators and justification of wife beating increased odds.

Conclusion
Spatial variations in intimate partner violence risk for women in Kenya underscore the need for targeted government interventions. Focusing on hotspot regions, especially among women with the poorest wealth index, no formal education, and older age, is crucial. Implementing behavior change campaigns addressing violence justification and partner dominance is vital. Active involvement of male partners in programs aiming to eliminate intimate partner violence is essential for comprehensive impact.
Characteristics and treatment of pediatric nasal foreign bodies with button batteries-A retrospective analysis of 176 cases
Authors: Yan Shang , Chen Guowei , Zeng Nan , Gao Chaobing 
Published: August 2024

Purpose
Button battery nasal impactions pose serious risks due to complications and the need for prompt removal, yet research on interventions remains limited due to its rare occurrence. To delineate the clinical manifestations of nasal foreign bodies associated with button batteries and to explore treatment approaches focused on minimizing the reliance on general anesthesia and surgical interventions.

Methods
This study focuses on 176 cases of children who received treatment for nasal cavity button battery impactions. It encompasses various factors including age, gender, battery location, impaction duration, methods of extraction, and associated complications.

Results
The incidence of nasal button battery cases among nasal foreign body instances was 1.16%, with a majority being males (60.23%) aged 1–5 years (98.29%). Utilizing a specially designed nasal foreign body hook and following established treatment protocols enabled the successful outpatient management of the majority of cases. Only 12 cases (6.82%) necessitated removal under general anesthesia due to management challenges in an outpatient setting. Furthermore, our findings indicated no linear correlation between the duration of battery retention and the risk of nasal septal perforation, which was observed in 31 cases (17.61%).

Conclusion
Nasal foreign bodies caused by button batteries in children demand urgent attention due to their potentially grave outcomes. Our research is directed towards enhancing diagnostic and therapeutic strategies to bolster the success rates of outpatient removal, curtail the duration of foreign body retention, and diminish the reliance on general anesthesia.
Citizens’ perspectives on relocating healthcare
Authors: Damen L. J. , De Jong J. D. , Van Tuyl L. H. D. , Korevaar J. C. 
Published: August 2024

Background
Healthcare systems around the globe are facing challenges. There are increasing demands and costs at the same time as a diminishing health workforce. Without change, healthcare will become unsustainable. The Dutch government is searching for solutions, one of which is relocating healthcare. Relocating healthcare from expensive institutions to sites closer to patients’ homes is an important part of this. This relocation is expected to reduce costs and lessen shortages of personnel. However, although citizens have an important stake in this, little is known about how they think about this topic. This research aims at investigating citizens’ perspectives on relocating care.

Methods
In December 2021, three open-ended questions were sent to 1,500 members of Nivel’s Dutch Healthcare Consumer Panel, 796 respondents responded. In addition, two citizen platforms were organised in March and April 2022. A total of 23 citizens participated.

Results
Our results indicated that the following aspects are important for citizens in healthcare delivery: being treated by someone with expertise in the area of their need, familiarity with the healthcare provider and the treatment of less complex care close to home. When certain conditions are met, citizens prefer treatment for less complex care from their general practitioner rather than in a hospital. The most important condition is that the general practitioner has the right expertise regarding their health question. The willingness to relocate care from the general practitioner to other healthcare providers or to self-care is also present. One of the problems, however, is that citizens often do not know to which healthcare provider they should go or what they should do to increase self-care.

Conclusion
From a citizens’ perspective, relocating care is an acceptable solution for keeping healthcare sustainable in the future, provided that certain conditions are met.