bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized clinical trial of therapeutic music video intervention for resilience outcomes in adolescents/young adults undergoing hematopoietic stem cell transplant: A report from the Children's Oncology Group
Authors: Robb Sheri L. , Burns Debra S. , Stegenga Kristin A. , Haut Paul R. , Monahan Patrick O. , Meza Jane , Stump Timothy E. , Cherven Brooke O. , Docherty Sharron L. , Hendricks‐Ferguson Verna L. , Kintner Eileen K. , Haight Ann E. , Wall Donna A. , Haase Joan E. 
Published: January 2014

BACKGROUNDTo reduce the risk of adjustment problems associated with hematopoietic stem cell transplant (HSCT) for adolescents/young adults (AYAs), we examined efficacy of a therapeutic music video (TMV) intervention delivered during the acute phase of HSCT to: 1) increase protective factors of spiritual perspective, social integration, family environment, courageous coping, and hope‐derived meaning; 2) decrease risk factors of illness‐related distress and defensive coping; and 3) increase outcomes of self‐transcendence and resilience.METHODSThis was a multisite randomized, controlled trial (COG‐ANUR0631) conducted at 8 Children's Oncology Group sites involving 113 AYAs aged 11‐24 years undergoing myeloablative HSCT. Participants, randomized to the TMV or low‐dose control (audiobooks) group, completed 6 sessions over 3 weeks with a board‐certified music therapist. Variables were based on Haase's Resilience in Illness Model (RIM). Participants completed measures related to latent variables of illness‐related distress, social integration, spiritual perspective, family environment, coping, hope‐derived meaning, and resilience at baseline (T1), postintervention (T2), and 100 days posttransplant (T3).RESULTSAt T2, the TMV group reported significantly better courageous coping (Effect Size [ES], 0.505; P = .030). At T3, the TMV group reported significantly better social integration (ES, 0.543; P = .028) and family environment (ES, 0.663; P = .008), as well as moderate nonsignificant effect sizes for spiritual perspective (ES, 0.450; P = .071) and self‐transcendence (ES, 0.424; P = .088).CONCLUSIONSThe TMV intervention improves positive health outcomes of courageous coping, social integration, and family environment during a high‐risk cancer treatment. We recommend the TMV be examined in a broader population of AYAs with high‐risk cancers. Cancer 2014;120:909–917. © 2013 American Cancer Society.
Mixed Quantum‐Classical Description of Excitation Energy Transfer in Supramolecular Complexes: Screening of the Excitonic Coupling
Authors: Megow Jörg , Renger Thomas , May Volkhard 
Published: January 2014

AbstractA mixed quantum‐classical description of excitation energy transfer (EET) in large chromophore complexes with significant conformational flexibility is improved by considering screening and local‐field effects. To account for the environmentally induced modification of the excitonic coupling Jmn(ε>1) between chromophore m and n, the Poisson‐transition‐charges‐from‐electrostatic‐potential (Poisson‐TrEsp) method is utilized. A parameterization scheme for the such derived screening/local field factors is introduced, which allows for their incorporation to a mixed quantum‐classical description. The method is applied to the supramolecular complex P16 formed by sixteen pheophorbide‐a molecules covalently linked to a butanediamine dendrimer and dissolved in ethanol. Data calculated using the novel parameterized screening method are compared to those obtained by alternative screening approaches. Averaging the screening factors in different ways may reproduce ensemble experiments on EET well, while the description of single molecule properties requires the consideration of individual screening factors.
Mobility Analysis of Super‐Resolved Proteins on Optically Stretched DNA: Comparing Imaging Techniques and Parameters
Authors: Heller Iddo , Sitters Gerrit , Broekmans Onno D. , Biebricher Andreas S. , Wuite Gijs J. L. , Peterman Erwin J. G. 
Published: January 2014

AbstractFluorescence microscopy in conjunction with optical tweezers is well suited to the study of protein mobility on DNA. Here, we evaluate the benefits and drawbacks of super‐resolution and conventional imaging techniques for the analysis of one‐dimensional (1D) protein diffusion as commonly observed for DNA‐binding proteins. In particular, we demonstrate the visualization of DNA‐bound proteins using wide‐field, confocal, and stimulated emission depletion (STED) microscopy. We review the suitability of these techniques to conditions of high protein density, and quantify their performance in terms of spatial and temporal resolution. Tracking proteins on DNA forces one to make a choice between localization precision on the one hand, and the number and rate of localizations on the other, by altering imaging modality, excitation intensity, and acquisition rate. Using simulated diffusion data, we quantify the effect of these imaging conditions on the accuracy of 1D diffusion analysis. In addition, we consider the case of diffusion confined between local roadblocks, a case particularly relevant for proteins bound to DNA. Together these results provide guidelines that can assist in judiciously optimizing the experimental conditions required for the analysis of protein mobility on DNA and other 1D systems.
From the Molecular Structure to Spectroscopic and Material Properties: Computational Investigation of a Bent‐Core Nematic Liquid Crystal
Authors: Greco Cristina , Marini Alberto , Frezza Elisa , Ferrarini Alberta 
Published: January 2014

AbstractWe present a computational investigation of the nematic phase of the bent‐core liquid crystal A131. We use an integrated approach that bridges density functional theory calculations of molecular geometry and torsional potentials to elastic properties through the molecular conformational and orientational distribution function. This unique capability to simultaneously access different length scales enables us to consistently describe molecular and material properties. We can reassign13C NMR chemical shifts and analyze the dependence of phase properties on molecular shape. Focusing on the elastic constants we can draw some general conclusions on the unconventional behavior of bent‐core nematics and highlight the crucial role of a properly‐bent shape.
Evaluation of Limiting Factors Affecting Photovoltaic Performance of Low‐Temperature‐Processed TiO2 Films in Dye‐Sensitized Solar Cells
Authors: Lee Taek‐Yong , Kim Hui‐Seon , Park Nam‐Gyu 
Published: January 2014

AbstractLimiting factors affecting photovoltaic performance of dye‐sensitized solar cell employing low‐temperature‐processed TiO2 films were investigated. TiO2 films were prepared at a low temperature of 200 °C using the normal alcohol‐containing binder‐free TiO2 paste (LT200). Their photovoltaic performance was compared to a high‐temperature (550 °C) annealed TiO2 film prepared using a polymer binder containing TiO2 paste (HT550). Compared to the proportional increase in conversion efficiency with TiO2 film thickness upto 14 μm for HT550, the increase in efficiency was terminated at relatively smaller thickness of about 8 μm for LT200 mainly due to unaugmented photocurrent. From the transient photocurrent–voltage studies, the electron transport rate was found to be almost identical, while charge recombination was one order of magnitude faster for LT200. Consequently, the electron diffusion length was more than 2–3 times shorter for LT200 than for HT550. Electron diffusion length and electron life time obtained from electrochemical impedance analysis were well consistent with those observed from transient measurement. Density of states (DOS) was evaluated to be shallow and narrow in LT200, which was responsible for limiting photovoltaic performance in the low‐temperature processed TiO2 film.
Research on the memory order of the power‐line communication channel
Authors: Zhai Ming‐Yue , Su Ling‐Dong 
Published: January 2014

SummaryAs a memory channel, power‐line communication (PLC) channel can be modeled by the finite states Morkov model. The memory order in an finite states Morkov model is a key parameter, which is not solved in PLC systems yet. In the paper, the mutual information is used as a measure of the dependence between the different symbols, treated as the received scalar network analyzer, or amplitude of the current channel symbol or that of previous symbols. The joint distribution probabilities of the envelopes in PLC systems are computed based on the multi‐path channel model, which is commonly used in PLC. With the first‐order Markovian assumption, we confirm that given the information of the symbol immediately preceding the current one, any other previous symbol is independent of the current one in PLC systems. The field test is also performed to model the received OFDM signals with the help of autoregressive model. The results show that the first‐order autoregressive model is enough to model the fading channel in PLC systems, which means the amount of uncertainty remaining in the current symbol should be negligible, given the information corresponding to the immediately preceding one. Copyright © 2014 John Wiley & Sons, Ltd.
Alkane Elimination Reactions between Yttrium Alkyls and Tungsten Hydrides
Authors: Sobaczynski Adam P. , Obenauf Johannes , Kempe Rhett 
Published: January 2014

AbstractAlkane elimination of the yttrium monoalkyl [Cp2Y(CH2SiMe3)(thf)] (Cp = cyclopentadienyl, thf = tetrahydrofuran, Me = methyl) with the tungsten hydrido carbonyl complex [HW(CO)3Cp] in THF gave rise to the trinuclear complex [{CpW(CO)2(μ‐CO)}2YCp(thf)3] (1). In the course of the reaction, one Cp ligand per yttrium was redistributed, thus leading to the formation of [Cp3Y] as a side product. To avoid the observed ligand redistribution, other solvents were investigated. The reaction of [Cp2Y(CH2SiMe3)(thf)] with [HW(CO)3Cp] in acetonitrile afforded the dinuclear complex [{CpW(CO)2(μ‐CO)}YCp2(NCMe)2] (2). The reaction of the yttrium dialkyl complex [Y(CH2SiMe3)2(OC6H3tBu2‐2,6)(thf)2] with [HW(CO)3Cp] in toluene gave the polymeric compound [{CpW(CO)2(μ‐CO)}2Y(OC6H3tBu2‐2,6)]n (3), whereas reaction in THF gave the molecular compound [{CpW(CO)2(μ‐CO)}2Y(OC6H3tBu2‐2,6)(thf)3] (4). The reaction of the yttrium trialkyl complex [Y(CH2SiMe3)3(thf)2] with [HW(CO)3Cp] in THF led to the formation of [{CpW(CO)2(μ‐CO)}3Y(thf)5] (5). Reaction of [(Ap*)Y(CH2SiMe3)2(thf)] {Ap*H = (2,6‐diisopropylphenyl)‐[6‐(2,4,6‐triisopropylphenyl)pyridin‐2‐yl]amine} with [HW(CO)3Cp] in THF was unexpectedly accompanied by the loss of the Ap* ligand and resulted in the formation of 5 too. Isocarbonyl linkage is the dominating interaction between the Y and the W complex moieties. All compounds were characterized by NMR and IR spectroscopy as well as elemental analysis. Complexes 1, 2, 4, and 5 were additionally characterized by X‐ray crystal structure analysis (X‐ray diffraction).
Synthesis and Characterization of para‐Substituted N,N′‐Dihydroxybenzamidines and Their Derivatives as Model Compounds for a Class of Prodrugs
Authors: Schwarz Laura , Girreser Ulrich , Clement Bernd 
Published: January 2014

AbstractA synthetic strategy for previously unknown para‐substituted N,N′‐dihydroxybenzamidines and their O‐monosubstituted and O,O′‐disubstituted methyl, benzyl, and tetrahydropyranyl derivatives is described. The procedure starts with the corresponding hydroxamic acid chlorides, which after dehydrohalogenation give nitrile oxides. These intermediates in turn react with O‐substituted hydroxylamines to afford the desired N,N′‐dihydroxybenzamidines after workup. This new class of potential prodrugs was characterized by 15N NMR spectroscopy. The chemical shifts show significant correlations with Hammett σ values, especially for the oxime‐type nitrogen with r2 > 0.99. The Hammett σ parameter reliably correlates with electron density in molecules. The presented results thus allow predictions relating to π‐electron density and basicity in this functional group, and these are important parameters for the discussion of substrate enzyme interactions.
Wrestling with stress: Roles of protein SUMOylation and deSUMOylation in cell stress response
Authors: Guo Chun , Henley Jeremy M. 
Published: January 2014

AbstractHow cell fate is determined following extreme stress is a core question in cell biology. This is particularly important in the brain where neuronal death following ischemic stroke is a major cause of disability. Over the last few years it has emerged that the SUMOylation status of an increasing number of substrate proteins plays a crucial role in cellular responses to environmental and metabolic stress. SUMOylation is a post‐translational modification in which the 97‐residue protein, SUMO (Small Ubiquitin‐related MOdifier) is covalently attached to specific lysine residues in a target protein. Despite being covalent, it is a highly transient modification because of the actions of deSUMOylation enzymes, so SUMO conjugation acts as a rapidly reversible switch that can promote or inhibit protein interactions with the substrate protein. Overall, it appears that increased SUMOylation represents a cellular protective response. Here we discuss recent progress toward understanding the mechanisms, pathways, and roles of SUMOylation during and after severe metabolic stress. © 2014 IUBMB Life, 66(2):71–77, 2014
Loss of Cbl–PI3K Interaction Enhances Osteoclast Survival due to p21‐Ras Mediated PI3K Activation Independent of Cbl‐b
Authors: Adapala Naga Suresh , Barbe Mary F. , Tsygankov Alexander Y. , Lorenzo Joseph A. , Sanjay Archana 
Published: January 2014

ABSTRACTCbl family proteins, Cbl and Cbl‐b, are E3 ubiquitin ligases and adaptor proteins, which play important roles in bone‐resorbing osteoclasts. Loss of Cbl in mice decreases osteoclast migration, resulting in delayed bone development where as absence of Cbl‐b decreases bone volume due to hyper‐resorptive osteoclasts. A major structural difference between Cbl and Cbl‐b is tyrosine 737 (in YEAM motif) only on Cbl, which upon phosphorylation interacts with the p85 subunit of phosphatidylinositol‐3 Kinase (PI3K). In contrast to Cbl−/− and Cbl‐b−/−, mice lacking Cbl–PI3K interaction due to a Y737F (tyrosine to phenylalanine, YF) mutation showed enhanced osteoclast survival, but defective bone resorption. To investigate whether Cbl–PI3K interaction contributes to distinct roles of Cbl and Cbl‐b in osteoclasts, mice bearing CblY737F mutation in the Cbl‐b−/− background (YF/YF;Cbl‐b−/−) were generated. The differentiation and survival were augmented similarly in YF/YF and YF/YF;Cbl‐b−/− osteoclasts, associated with enhanced PI3K signaling suggesting an exclusive role of Cbl–PI3K interaction, independent of Cbl‐b. In addition to PI3K, the small GTPase Ras also regulates osteoclast survival. In the absence of Cbl–PI3K interaction, increased Ras GTPase activity and Ras–PI3K binding were observed and inhibition of Ras activation attenuated PI3K mediated osteoclast survival. In contrast to differentiation and survival, increased osteoclast activity observed in Cbl‐b−/− mice persisted even after introduction of the resorption‐defective YF mutation in YF/YF;Cbl‐b−/− mice. Hence, Cbl and Cbl‐b play mutually exclusive roles in osteoclasts. Whereas Cbl–PI3K interaction regulates differentiation and survival, bone resorption is predominantly regulated by Cbl‐b in osteoclasts. J. Cell. Biochem. 115: 1277–1289, 2014. © 2014 Wiley Periodicals, Inc.
Structural Diversity in the Self‐assembly of Cd(II) Complexes Containing 2,6‐Dimethyl‐3,5‐dicyano‐4‐(4‐pyridyl)‐1,4‐dihydropyridine
Authors: Yeh Chun‐Wei , Huang Fu‐Chang , Jong Ay , Tsou Chi‐Hui , Suen Maw‐Cherng 
Published: January 2014

AbstractThe syntheses, structures and properties of the complexes [CdBr2(L)2·4H2O]n [L = 2,6‐dimethyl‐3,5‐dicyano‐4‐(4‐pyridyl)‐1,4‐dihydropyridine], 1 and [Cd(SCN)2(L)2(H2O)]n, 2, are reported. In polymeric complexes 1 — 2, the L ligands bridge the metal centers through the pyrimidyl and cyano nitrogen atoms forming 1‐D double‐stranded chain and zigzag chain, respectively. The L ligands in complex 1 act as κ1, κ1‐bidentate bridging ligand, whereas the L ligands in complex 2 act as κ1‐monodentae and κ1, κ1‐bidentate bridging ligand. The molecules of these complexes are interlinked through various weak interactions that form the packed structure. All the complexes exhibit emissions which may be tentatively assigned as intraligand (IL) π→π* transitions.
Oncological benefit of preoperative endoscopic biliary drainage in patients with hilar cholangiocarcinoma
Authors: Hirano Satoshi , Tanaka Eiichi , Tsuchikawa Takahiro , Matsumoto Joe , Kawakami Hiroshi , Nakamura Toru , Kurashima Yo , Ebihara Yuma , Shichinohe Toshiaki 
Published: January 2014

Abstract Due to advances in endoscopic equipment and techniques, preoperative endoscopic biliary drainage (EBD) has been developed to serve as an alternative to percutaneous transhepatic biliary drainage (PTBD). This study sought to clarify the benefit of EBD in comparison to PTBD in patients who underwent radical resections of hilar cholangiocarcinoma. One hundred and forty‐one patients underwent radical surgery for hilar cholangiocarcinoma between 2000 and 2008 were retrospectively divided into two groups based on the type of preoperative biliary drainage, PTBD (n = 67) or EBD (n = 74). We investigated if the different biliary drainage methods affected postoperative survival and mode of recurrence after median observation period of 82 months. The survival rate for patients who underwent EBD was significantly higher than those who had PTBD (P = 0.004). Multivariate analysis revealed that PTBD was one of the independent factors predictive of poor survival (hazard ratio: 2.075, P = 0.003). Patients with PTBD more frequently developed peritoneal seeding in comparison to those who underwent EBD (P = 0.0003). PTBD was the only independent factor predictive of peritoneal seeding. In conclusion, EBD might confer an improved prognosis over PTBD due to prevention of peritoneal seeding, and is recommended as the initial procedure for preoperative biliary drainage in patients with hilar cholangiocarcinoma.
Associations between tumor vascularization assessed by in vivo DCE‐MRI and the presence of disseminated tumor cells in bone marrow in breast cancer patients at the time of diagnosis
Authors: Nilsen Line B. , Fangberget Anne , Geier Oliver M. , Engebraaten Olav , Borgen Elin , Olsen Dag Rune , Seierstad Therese 
Published: January 2014

PurposeTo explore possible associations between in vivo pharmacokinetic dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) parameters and the presence of disseminated tumor cells (DTCs) in bone marrow in breast cancer patients at the time of diagnosis.Materials and MethodsThirty‐seven women with breast cancer (stage T2–4N0–1M0) were included. Patients were classified as DTC+ if one or more DTCs were detected by immunocytochemistry. DCE‐MRI was acquired with a radial 3D T1‐weighted spoiled gradient echo sequence with k‐space weighted image contrast. Ktrans, kep, and ve were calculated using the extended Tofts model and a population‐derived arterial input function. The nonparametric Mann–Whitney U‐test was used to compare the histogram distributions of the pharmacokinetic parameters for the DTC+ and the DTC− patients.ResultsDTCs were detected in 7 of the 37 patients (19%). In DTC+ patients, the distribution of tumor Ktrans and kep were significantly (P < 0.01) more shifted towards lower values than in DTC− patients.ConclusionAn association between vascular dependent pharmacokinetic DCE‐MRI parameters and the presence of DTCs were found. Compared to DTC− patients, DTC+ patients had poorer perfusion and permeability, indicative of hypoxia. Thus, pharmacokinetic parameters might be surrogate biomarkers of metastatic potential and future relapse.J. Magn. Reson. Imaging 2014;40:1382–1391. © 2014 Wiley Periodicals, Inc.
Cisterna chyli in autosomal dominant polycystic kidney disease
Authors: Thimmappa Nanda Deepa , Blumenfeld Jon D. , Cerilles Michelle Ann C. , Dunning Allison , Donahue Stephanie L. , Bobb Warren O. , Zhang Hong Lei , Prince Martin R. 
Published: January 2014

PurposeAfter observing prominent cisterna chyli in several patients with autosomal dominant polycystic kidney disease (ADPKD), we investigated the potential association of cistern chyli enlargement with ADPKD.Materials and MethodsRetrospective, cross‐sectional analysis of abdominal and pelvic MRI at 1.5 Tesla (T) in 70 ADPKD patients (male 44.3%, 20–83 years, median = 53 years) were compared with 70 age and gender matched control subjects without ADPKD, cirrhosis, or cholestasis. Cisterna chyli diameter was measured on axial single shot fast spin echo (SSFSE) images at the level of T12–L2 and evaluated by multivariable regression models with covariates including estimated glomerular filtration rate (eGFR), total kidney volume (TKV), renal cyst fraction (cyst volume/kidney volume), and liver volume.ResultsSubjects with ADPKD had larger median cisterna chyli diameter compared with those without ADPKD (6.1 mm versus 3.4 mm, P < 0.0001). The prevalence of cisterna chyli enlargement more than the median (3.4 mm), was greater in ADPKD than in controls (99% versus 51%, P < 0.0001). On univariate analysis, cisterna chyli diameter was inversely correlated with eGFR (r = −0.41; P < 0.0001) and directly correlated with TKV (r = 0.57; P < 0.0001), total renal cyst fraction (r = 0.61; P < 0.001), and liver volume (r = 0.17; P = 0.040). Multivariable linear regression modeling found a significant association of cisterna chyli diameter with ADPKD diagnosis (B = 2.14; 95% confidence interval [CI]: 0.05–4.23; P = 0.04). Logistic regression analysis confirmed the association of ADPKD with an enlarged cisterna chyli diameter (odds ratio = 68.4; 95%CI: 8.9–524, P < 0.0001).ConclusionEnlarged cisterna chyli is highly prevalent in ADPKD patients but not in age and gender‐matched controls. J. Magn. Reson. Imaging 2015;41:142–148. © 2014 Wiley Periodicals, Inc.
Statistical relationship between remote climate indices and West African monsoon variability
Authors: Diatta Samo , Fink Andreas H. 
Published: January 2014

ABSTRACTThis paper revisits the strength and stationarity of linear statistical relationships between indices of monsoon rainfall derived from rain gauge data for three regions in tropical West Africa [West Sahel (WS), Central Sahel (CS), and Guinea Coast (GC)] and various indices describing remote variations in the ocean–atmosphere climate systems from 1921 to 2009. The results reveal that both the Atlantic Multi‐decadal Oscillation (AMO) and the Atlantic Meridional Mode (AMM) show a positive linear correlation to Sahel rainfall. The percent variance explained (PVE) ranges from 10 to 25%. The correlation stems from periods longer than 8 years for AMO, but AMM does show a correlation on interannual time scales for WS that was absent in the 1970s and 1980s. The PVE by El Niño Southern Oscillation (ENSO) indices is, though statistically significant, on the order of 10% and found mainly on the interannual time scale. A strong and stable correlation with PVEs larger than 50% is found between the sea surface temperatures (SSTs) in the Atlantic 3 region (ATL3, 0°–20°W, 3°S–3°N) and the GC rainfall. On the other hand, the correlation between ATL3 and WS rainfall changed from significantly negative to significantly positive after the 1970s. The Eastern Mediterranean SSTs are found to be significantly related to CS rainfall, especially in recent years with PVEs between 36 and 47%. Multi‐linear regression analyses reveal that the relative importance of the Indian Ocean is 42% in the optimal regression model. For the CS, this value is 37% for the Eastern Mediterranean SSTs and 70% in case of the GC using the ATL3 index. However, except for the GC, non‐stationarities in the correlation between the climate state indexes and West African monsoon (WAM) rainfall suggest the need of the application of different regression models depending on the active ‘teleconnection regime’.