bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient with an SLC26A4 gene mutation who had low-frequency sensorineural hearing loss and endolymphatic hydrops
Authors: Yoshida T , Sone M , Naganawa S , Nakashima T 
Published: January 2015

AbstractObjective:To report magnetic resonance imaging findings in a patient with an SLC26A4 gene mutation who had low-frequency sensorineural hearing loss.Case report:A 13-year-old girl had bilateral and symmetric low-frequency sensorineural hearing loss. Upon genetic testing, a heterozygous c.1105A > G (p.K369E) mutation of the SLC26A4 gene was detected. Mild endolymphatic hydrops in the right cochlea and marked endolymphatic hydrops in the left vestibulum were seen by magnetic resonance imaging 4 hours after an intravenous gadolinium injection.Conclusion:This is the first reported case of a patient with the SLC26A4 gene mutation c.1105A > G (p.K369E) who had low-frequency sensorineural hearing loss. Co-occurrence of cochlear and vestibular endolymphatic hydrops suggests an association with that pathology.
Contemplation as an alternative to curiosity: St Bonaventure on Ecclesiastes 1:3–11
Authors: Atkinson Tyler 
Published: January 2015

AbstractThis article seeks to offer a christological interpretation of the opening poem in Ecclesiastes (1:3–11) through engagement with St Bonaventure's exegesis of the passage. It begins with a brief survey of contemporary treatments of the passage, which are characterised by an emphasis on cosmic monotony as an illustration of the futility of human labour. Then, it examines the Seraphic Doctor's version of thecontemptus mundiinterpretation of the book, relating it to his metaphysics of emanation, exemplarity and consummation. It will be suggested that Bonaventure's version ofcontemptus mundiinforms an alternative interpretation to the critical status quo.In his exegesis of the opening poem, Bonaventure begins by describing three kinds of existence: existence in the eternal and unchanging Word, material existence in the cosmos, and abstract existence in the mind. While Bonaventure does not consider existence in the Word in relation to Ecclesiastes 1:3–11, because such existence is not subject to the vanity of mutability, the conclusion of the article will propose that such existence is in view in the text. When Bonaventure considers material existence, his metaphysics will not allow him to read the cosmological motion in Ecclesiastes 1:5–7 as monotonous, but rather as creaturely movement which invites contemplation. When he considers abstract existence, he contrasts the movement of heavenly and elemental creatures with the dissatisfaction of human perception, constrained by curiosity, the vice which characterises the protagonist's pursuits in Ecclesiastes 1:12–2:26. Thus, it will be suggested from Bonaventure's exegesis that the problem in Ecclesiastes 1:3–11 is not an oppressively monotonous universe which shows humans how pointless their own movement is, but rather humanity's failing to treat the cosmos as a book which speaks of God.In the article's final section, a relationship between the contemplative reading of Ecclesiastes 1:3–11 and Bonaventure'sItinerariumwill be outlined. The consideration of material existence in Ecclesiastes 1:4–7 will be related to contemplation through vestiges. Then a contrast between the perceptual rupture of Ecclesiastes 1:8–11 and contemplation through the divine image in humanity will be shown. Finally, a christological reading of Ecclesiastes 1:10a will be offered, suggesting that this verse gestures towards the incarnate Word, who reforms the divine image in humanity and thus places humanity back on course towards similitude. It will be suggested in closing that, in signalling this hope, Ecclesiastes 1:10a prepares one for the union with Christ which Song of Songs depicts.
Native English speakers learning Arabic: The influence of novel orthographic information on second language phonological acquisition
Authors: SHOWALTER CATHERINE E. , HAYES-HARB RACHEL 
Published: January 2015

ABSTRACTRecent research has indicated that learners exposed to second language words’ orthographic forms of words can often use this information to make inferences about the words’ phonological forms. Here we asked, do learners benefit even when the orthography is unfamiliar? We taught native English speakers minimal nonword pairs differentiated by the Arabic velar–uvular contrast (e.g., [kubu], [qubu]) and manipulated the quality of orthographic input. We found that participants were consistently unable to associate the novel phonemes with novel words. Results are discussed in terms of (a) the role of orthographic input in second language word form learning, (b) the influence of orthographic familiarity in moderating the role of orthographic input, and (c) the issue of talker variability in word learning.
Pilot simulation study using meat inspection data for syndromic surveillance: use of whole carcass condemnation of adult cattle to assess the performance of several algorithms for outbreak detection
Authors: DUPUY C. , MORIGNAT E. , DOREA F. , DUCROT C. , CALAVAS D. , GAY E. 
Published: January 2015

SUMMARYThe objective of this study was to assess the performance of several algorithms for outbreak detection based on weekly proportions of whole carcass condemnations. Data from one French slaughterhouse over the 2005–2009 period were used (177 098 slaughtered cattle, 0.97% of whole carcass condemnations). The method involved three steps: (i) preparation of an outbreak-free historical baseline over 5 years, (ii) simulation of over 100 years of baseline time series with injection of artificial outbreak signals with several shapes, durations and magnitudes, and (iii) assessment of the performance (sensitivity, specificity, outbreak detection precocity) of several algorithms to detect these artificial outbreak signals. The algorithms tested included the Shewart p chart, confidence interval of the negative binomial model, the exponentially weighted moving average (EWMA); and cumulative sum (CUSUM). The highest sensitivity was obtained using a negative binomial algorithm and the highest specificity with CUSUM or EWMA. EWMA sensitivity was too low to select this algorithm for efficient outbreak detection. CUSUM's performance was complementary to the negative binomial algorithm. The use of both algorithms on real data for a prospective investigation of the whole carcass condemnation rate as a syndromic surveillance indicator could be relevant. Shewart could also be a good option considering its high sensitivity and simplicity of implementation.
Emotion-based preventive intervention: Effectively promoting emotion knowledge and adaptive behavior among at-risk preschoolers
Authors: Finlon Kristy J. , Izard Carroll E. , Seidenfeld Adina , Johnson Stacy R. , Cavadel Elizabeth Woodburn , Ewing E. Stephanie Krauthamer , Morgan Judith K. 
Published: January 2015

AbstractEffectiveness studies of preschool social–emotional programs are needed in low-income, diverse populations to help promote the well-being of at-risk children. Following an initial program efficacy study 2 years prior, 248 culturally diverse Head Start preschool children participated in the current effectiveness trial and received either the Emotion-Based Prevention Program (EBP) or the I Can Problem Solve (ICPS) intervention. Pre- and postdata collection included direct child assessment, teacher report, parent interview, and independent observations. Teachers implementing the EBP intervention demonstrated good and consistent fidelity to the program. Overall, children in EBP classrooms gained more emotion knowledge and displayed greater decreases in negative emotion expressions and internalizing behaviors across the implementation period as compared to children in ICPS classrooms. In addition, cumulative risk, parental depressive symptoms, and classroom climate significantly moderated treatment effects. For children experiencing more stress or less support, EBP produced more successful outcomes than did ICPS. These results provide evidence of EBP sustainability and program effectiveness, as did previous findings that demonstrated EBP improvements in emotion knowledge, regulation skills, and behavior problems replicated under unsupervised program conditions.
Vaccine Administration by Paramedics: A Model for Bioterrorism and
Disaster Response Preparation
Authors: Walz Bruce J. , Bissell Richard A. , Maguire Brian , Judge James A. 
Published: January 2015

Abstract
The events of 11 September 2001 have had a profound effect on disaster
planning efforts in the United States. This is true especially in the area
of bioter-rorism. One of the major tenets of bioterrorism response is the
vaccination of at-riskpopulations. This paper investigates the efficacy of
training emergency medical services paramedics to administer vaccines in
public health settings as preparation for and response to bioterrorism
events and other disaster events.
The concept of vaccination administration by specially trained
paramedics is not new. Various programs to provide immunizations for
emergency services personnel and at-risk civilian populations have been
reported.
Vaccination programs by paramedics should follow the guidelines of the
National Vaccine Advisory Committee of the Centers for Disease Control and
Prevention (CDC). Thispaper compares the seven standards of the CDC
guidelines to routine paramedic practice and education. It is concluded that
paramedics are adequately trained to administer vaccines. However, specific
training and protocols are needed in the areas of administrative paperwork
and patient education. A proposed outline for a paramedic-training program
is presented.
Broadband MIMO antenna for HiperLAN/2, WLAN, and WiMAX applications with high isolation
Authors: El Bakouchi Raefat Jalila , Brunet Marc , Razban Tchanguiz , Ghammaz Abdelilah 
Published: January 2015

This paper presents a multiple-input and multiple-output dual-element planar inverted-F antenna (PIFA) array for broadband operation covering the HIgh PERformance radio Local Area Network/2 (5.2 GHz/5.6 GHz), Wireless Local Area Network (5.2 GHz/5.8 GHz), and the Worldwide Interoperability for Microwave Access (5.5 GHz) bands for the compact wireless communication devices. The antenna dimension is reduced substantially with a miniature ground plane. The PIFA array provides a large bandwidth (670 MHz) and a high isolation between its ports less than −26 dB. The proposed antenna has been analyzed and designed with Ansoft HFSS v.11. Then a prototype was fabricated and tested for its performance in terms of bandwidth, S-parameters, and radiation pattern. A parametric study is made to analyze the effect of different PIFA parameters on the operating frequency and the S-parameters. The diversity performances are evaluated using computer simulation technology microwave studio (CSTMWS). The broadband performance and the high isolation are achieved in both simulation and measurement.
The evolution of cyclopropenium ions into functional polyelectrolytes
Authors: Jiang Yivan , Freyer Jessica L. , Cotanda Pepa , Brucks Spencer D. , Killops Kato L. , Bandar Jeffrey S. , Torsitano Christopher , Balsara Nitash P. , Lambert Tristan H. , Campos Luis M. 
Published: January 2015

AbstractVersatile polyelectrolytes with tunable physical properties have the potential to be transformative in applications such as energy storage, fuel cells and various electronic devices. Among the types of materials available for these applications, nanostructured cationic block copolyelectrolytes offer mechanical integrity and well-defined conducting paths for ionic transport. To date, most cationic polyelectrolytes bear charge formally localized on heteroatoms and lack broad modularity to tune their physical properties. To overcome these challenges, we describe herein the development of a new class of functional polyelectrolytes based on the aromatic cyclopropenium ion. We demonstrate the facile synthesis of a series of polymers and nanoparticles based on monomeric cyclopropenium building blocks incorporating various functional groups that affect physical properties. The materials exhibit high ionic conductivity and thermal stability due to the nature of the cationic moieties, thus rendering this class of new materials as an attractive alternative to develop ion-conducting membranes.
The minimal clinically important difference of the control of allergic rhinitis and asthma test (CARAT): cross-cultural validation and relation with pollen counts
Authors: van der Leeuw Sander , van der Molen Thys , Dekhuijzen PN Richard , Fonseca Joao A , van Gemert Frederik A , Gerth van Wijk Roy , Kocks Janwillem WH , Oosterom Helma , Riemersma Roland A , Tsiligianni Ioanna G , de Weger Letty A , Oude Elberink Joanne NG , Flokstra-de Blok Bertine MJ 
Published: January 2015

Abstract
Background:
The Control of Allergic Rhinitis and Asthma Test (CARAT) monitors control of asthma and allergic rhinitis.

Aims:
To determine the CARAT’s minimal clinically important difference (MCID) and to evaluate the psychometric properties of the Dutch CARAT.

Methods:
CARAT was applied in three measurements at 1-month intervals. Patients diagnosed with asthma and/or rhinitis were approached. MCID was evaluated using Global Rating of Change (GRC) and standard error of measurement (s.e.m.). Cronbach’s alpha was used to evaluate internal consistency. Spearman’s correlation coefficients were calculated between CARAT, the Asthma Control Questionnaire (ACQ5) and the Visual Analog Scale (VAS) on airway symptoms to determine construct and longitudinal validity. Test–retest reliability was evaluated with intra-class correlation coefficient (ICC). Changes in pollen counts were compared with delta CARAT and ACQ5 scores.

Results:
A total of 92 patients were included. The MCID of the CARAT was 3.50 based on GRC scores; the s.e.m. was 2.83. Cronbach’s alpha was 0.82. Correlation coefficients between CARAT and ACQ5 and VAS questions ranged from 0.64 to 0.76 (P<0.01). Longitudinally, correlation coefficients between delta CARAT scores and delta ACQ5 and VAS scores ranged from 0.41 to 0.67 (P<0.01). Test–retest reliability showed an ICC of 0.81 (P<0.01) and 0.80 (P<0.01). Correlations with pollen counts were higher for CARAT than for ACQ5.

Conclusions:
This is the first investigation of the MCID of the CARAT. The CARAT uses a whole-point scale, which suggests that the MCID is 4 points. The CARAT is a valid and reliable tool that is also applicable in the Dutch population.
Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy
Authors: Chumakov Ilya , Nabirotchkin Serguei , Cholet Nathalie , Milet Aude , Boucard Aurélie , Toulorge Damien , Pereira Yannick , Graudens Esther , Traoré Sory , Foucquier Julie , Guedj Mickael , Vial Emmanuel , Callizot Noëlle , Steinschneider Rémy , Maurice Tangui , Bertrand Viviane , Scart-Grès Catherine , Hajj Rodolphe , Cohen Daniel 
Published: January 2015

AbstractAlzheimer disease (AD) represents a major medical problem where mono-therapeutic interventions demonstrated only a limited efficacy so far. We explored the possibility of developing a combinational therapy that might prevent the degradation of neuronal and endothelial structures in this disease. We argued that the distorted balance between excitatory (glutamate) and inhibitory (GABA/glycine) systems constitutes a therapeutic target for such intervention. We found that a combination of two approved drugs – acamprosate and baclofen – synergistically protected neurons and endothelial structures in vitro against amyloid-beta (Aβ) oligomers. The neuroprotective effects of these drugs were mediated by modulation of targets in GABA/glycinergic and glutamatergic pathways. In vivo, the combination alleviated cognitive deficits in the acute Aβ25–35 peptide injection model and in the mouse mutant APP transgenic model. Several patterns altered in AD were also synergistically normalised. Our results open up the possibility for a promising therapeutic approach for AD by combining repurposed drugs.
CMOS fully integrated reconfigurable power amplifier with efficiency enhancement for LTE applications
Authors: Tuffery A. , Deltimple N. , Kerhervé E. , Knopik V. , Cathelin P. 
Published: January 2015

A fully integrated power amplifier using a power cell switching technique, implemented in 65 nm CMOS technology is presented. The main objective of the proposed architecture is to significantly improve the efficiency at high power back‐off. To do so, distributed active transformers are used as the splitter, the combiner and the DC bias feed to partition the power requirements among the parallelised power cells. An individual cell can be dynamically turned ON/OFF according to the desired output power. At 2.5 GHz, the measured maximum output power is 28.2 dBm and the power‐added efficiency is improved for low level, +3.2 and +4.9% for 18 and 23.7 dBm, respectively.
Microgrid state estimation and control for smart grid and Internet of Things communication network
Authors: Rana M.M. , Li L. 
Published: January 2015

Given the significant concerns regarding carbon emissions from fossil fuels, global warming and energy crises, the renewable distributed energy resources (DERs) are having to be integrated in the smart grid (SG). The SG can spread intelligence of the energy distribution and control system from the central unit to long‐distance remote areas, thus enabling accurate state estimation (SE) and wide‐area real‐time monitoring of these intermittent energy sources. In contrast to the traditional methods of SE, a novel approach for SG SE is proposed based on concatenated coding structures, where the grid state is treated as a dynamic outer code and the recursive systematic convolutional code is seen as a concatenated inner code for protecting and redundancy in the system state. Furthermore, Kalman filter (KF)‐based online DERs SE and a discrete‐time linear quadratic regulation method are proposed to control these state deviations for the SG and the Internet of Things (IoTs) communication network, which can exploit the far‐reaching connectivity and privacy of DERs messages. Simulation results show that the proposed algorithm achieves 3 dB performance improvement compared with the existing KF.
Loss of autophagy causes a synthetic lethal deficiency in DNA repair
Authors: Liu Emma Y. , Xu Naihan , O’Prey Jim , Lao Laurence Y. , Joshi Sanket , Long Jaclyn S. , O’Prey Margaret , Croft Daniel R. , Beaumatin Florian , Baudot Alice D. , Mrschtik Michaela , Rosenfeldt Mathias , Zhang Yaou , Gillespie David A. , Ryan Kevin M. 
Published: January 2015

Significance
It is known that autophagy plays a major role in cellular homeostasis and impaired autophagy has been implicated in various forms of human disease. Here we investigate one way in which autophagy is critically connected to cellular integrity by showing that autophagy loss diminishes DNA repair by the error-free process, homologous recombination. As a result, this causes reliance on the error-prone process of nonhomologous end joining for repair of DNA double-strand breaks, providing one explanation of why autophagy-deficient cells accumulate genomic damage. These findings therefore have important implications for diseases in which autophagy is impaired and for therapeutic strategies designed to inhibit autophagy, particularly if autophagy inhibition is undertaken in combination with agents that cause genomic damage.
Deciphering Hatchery Stock Influences on Wild Populations of Vermont Lake Trout
Authors: Baillie Shauna M. , Blackie Craig , Gerardi Leonard , Bentzen Paul 
Published: January 2015

AbstractTo better understand the influence of hatchery practices on wild populations of Lake Trout Salvelinus namaycush, we used a landscape genetic approach to tease apart the population genetic patterns expected due to natural processes versus hatchery stocking, i.e., human‐mediated gene flow. In several lakes across our study area in Vermont, the presence of exogenous mitochondrial DNA haplotypes supported our human‐mediated gene flow hypothesis. Microsatellite DNA analyses showed introgression of hatchery genotypes into the wild populations. Nonetheless, clustering patterns within river drainages and signatures of isolation by distance were consistent with natural postglacial colonization. We conclude that though the genetic makeup of Vermont Lake Trout populations has been influenced by stocking, a lack of genetic bottlenecks and concordance with landscape processes suggests that much of the indigenous genetic diversity remains intact. We were able to attribute departures from expectations based on natural genetic patterns to hatchery introgression in specific lakes. To preserve the adaptive potential of local populations that have persisted since the last ice age, we suggest areas for which hatchery supplementation could be minimized.Received June 16, 2014; accepted September 12, 2014
Acquire: an open-source comprehensive cancer biobanking system
Authors: Dowst Heidi , Pew Benjamin , Watkins Chris , McOwiti Apollo , Barney Jonathan , Qu Shijing , Becnel Lauren B. 
Published: January 2015

Abstract
Motivation: The probability of effective treatment of cancer with a targeted therapeutic can be improved for patients with defined genotypes containing actionable mutations. To this end, many human cancer biobanks are integrating more tightly with genomic sequencing facilities and with those creating and maintaining patient-derived xenografts (PDX) and cell lines to provide renewable resources for translational research.
Results: To support the complex data management needs and workflows of several such biobanks, we developed Acquire. It is a robust, secure, web-based, database-backed open-source system that supports all major needs of a modern cancer biobank. Its modules allow for i) up-to-the-minute ‘scoreboard’ and graphical reporting of collections; ii) end user roles and permissions; iii) specimen inventory through caTissue Suite; iv) shipping forms for distribution of specimens to pathology, genomic analysis and PDX/cell line creation facilities; v) robust ad hoc querying; vi) molecular and cellular quality control metrics to track specimens’ progress and quality; vii) public researcher request; viii) resource allocation committee distribution request review and oversight and ix) linkage to available derivatives of specimen.
Availability and Implementation: Acquire implements standard controlled vocabularies, ontologies and objects from the NCI, CDISC and others. Here we describe the functionality of the system, its technological stack and the processes it supports. A test version Acquire is available at https://tcrbacquire-stg.research.bcm.edu; software is available in https://github.com/BCM-DLDCC/Acquire; and UML models, data and workflow diagrams, behavioral specifications and other documents are available at https://github.com/BCM-DLDCC/Acquire/tree/master/supplementaryMaterials.
Contact: becnel@bcm.edu