bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrastructural Study of Anti‐Tumor Effects of Tamoxifen in Two Malignant Melanoma Patients
Authors: Hirota Toru 
Published: April 2015

AbstractIn order to clarify the mode of action (tumor cell death) of tamoxifen in treatment for estrogen receptor (ER) negative malignant melanoma, we administered the usual adult dose (20 mg/day) or a low dose, 1/4 of the usual dose (5 mg/day), of tamoxifen for 2 months to 2 male patients and investigated ultrastructural changes in their melanoma cells from metastatic lesions before and after the treatment. After the 2‐month adminisration, metastatic nodules in both patients were reduced in size by approximately 50%. Histologically, their reduced nodules presented coagulation necrosis around the blood vessels. Electron microscopy of the necrosis revealed that melanoma cells were degenerated and disappeared; numerous aggregated melanosomes, free melanosomes, granular endoplasmic reticula, and lysosomes were present in the extracellular matrix and in the space between collagen fibers. The remaining melanoma cells had swollen cytoplasm and mitochondria with vacuolar changes. Cristae of mitochondria had disappeared. There was no infiltration of lymphocytes or histiocytes into the nodules. The organic changes of necrosis lesions were not observed. Because our two patients were ER negative, these effects of tamoxifen could be attributable to an action not mediated by ER.
Severe Cutaneous and Venous Damage after DIC Therapy
Authors: Yuasa Tetsuya , Taniguchi Yoshiki , Yamada Eigo , Inachi Shin , Shimizu Masayuki 
Published: April 2015

AbstractA 79‐year‐old woman with skin ulcers caused by disseminated intravascular coagulation (DIC) therapy is reported. The patient had been treated by injection of drugs, including gabexate mesilate, into the right great saphenous vein. The maximum concentration of gabexate mesilate was calculated as 0.893%. Although the drugs did not extravasate, purpura initially appeared around the affected vein, followed by brown pigmentation with infiltration and ulcers with widely necrotic tissue from the middle portion of her thigh to the malleolus along her right great saphenous vein. As the ulcer showed no tendency to heal for more than 3 months, surgical debridement and skin grafts were performed.
A Case of Multicentric Reticulohistiocytosis, Systemic Sclerosis and Sjögren Syndrome
Authors: Takahashi Machiko , Mizutani Hitoshi , Nakamura Yasuo , Shimizu Masayuki 
Published: April 2015

AbstractWe report the case of a 42‐year‐old Japanese woman who developed multicentric reticulohistiocytosis (MR) complicated by systemic sclerosis (SSc) and Sjögren syndrome (SS). The patient complained of tender nodules on the left hand, polyarthralgia in the finger joints and knees, and xerostomia. The skin nodules were distributed mainly on her hands and fingers with skin sclerosis. The serum anti‐nuclear test revealed anti‐centromere antibody and the discrete speckled pattern of anti‐nuclear antibody. The biopsy specimens from the finger nodule and the sclerotic finger skin showed a perivascular infiltration of multinucleated giant cells with ground‐glass cytoplasm and dermal thick collagen proliferation, respectively. The lip biopsy and sialography specimens showed periductal lymphocyte infiltration and apple tree‐like changes. Systemic corticosteroid treatment improved the polyarthritis, xerostomia, and skin sclerosis rapidly but suppressed the nodular lesions only gradually. This is the first report of a combined case of MR, SSc and SS. This multiple autoimmune complication suggests the involvement of an immunological disturbance in the pathogenesis of MR.
Unusual Multiple Keratoacanthoma in a Child Successfully Treated with 5‐Fluorouracil
Authors: Singal Archana , Mohanty Sandeep , Bhattacharya Sambit Nath , Baruah Manik C. , Singh Navjeevan 
Published: April 2015

AbstractA rare case of a child with multiple keratoacanthoma (KA) on the lower half of the body successfully treated with topical and intralesional 5‐fluorouracil (5FU) is described to confirm the therapeutic efficacy of 5FU in such cases.
Ingrown Nails: A Comparison of the Nail Matrix Phenolization Method with the Elevation of the Nail Bed‐Periosteal Flap Procedure
Authors: Mori Hiroki , Umeda Tadashi , Nishioka Kiyoshi , Iida Hideo , Aoki Kazuhiro , Yokoyama Akiko 
Published: April 2015

AbstractSeventy‐five procedures were performed on 62 patients with ingrown nails from 1992 to 1996. Those consisted of 51 nail matrix phenolization methods (NMP) and 24 elevation of the nail bed‐periosteal flap procedures (ENF). Ingrown nails were classified into type A (normal nail plate) and type B (incurved nail plate). The duration and intensity of postoperative pain were assessed, and the recurrence rate was monitered.The recurrence rate was 3.9% in the NMP group and 4.1% in the ENF group. Concerning the recurrence rate, there was no statistical significance between ENF and NMP in both types. Postoperative pain intensity was less in the NMP group than in the ENF group in both types (P<0.01). The same tendency was seen in postoperative pain duration. However, the NMP group had longer duration of wound healing compared with the ENF group in type A (P<0.01).We conclude that NMP is a recommendable treatment for most ingrown nails.
Acral Lentiginous Nevus
Authors: Han Kwang‐Ho , Cho Kwang‐Hyun 
Published: April 2015

AbstractIn non‐Caucasians, malignant melanoma most frequently affects the sole of the foot. To improve the prognosis in such patients, accurate diagnosis of early lesions is extremely important, and, to avoid potentially mutilating surgery, it is equally important to identify benign acral nevus. Clemente and colleagues recently proposed a new clinicopathological entity, designated acral lentiginous nevus (ALN) of the plantar skin. The clinical and histopathological characteristics of these nevi enable clinicians to distinguish them from ordinary nevi and melanoma. We report four additional cases of ALN, which can be classified as belonging to the “pseudomelanoma” group.
Ultrastructural Observation of Platelets from Patients with Progressive Systemic Sclerosis (PSS)
Authors: Maeda Manabu , Kachi Hisayo , Mori Shunji 
Published: April 2015

AbstractWe observed the ultrastructure of platelets from patients with PSS (7 cases; 48.2 ± 12.3 y‐old; M:F= 1:6) and healthy controls (HC) (5 cases; 44.8 ± 8.0 y‐old; M:F=1:4) by using transmission (TEM) and freeze‐fracture electron microscopy (FEM). The open canalicular system (OCS) connected with the plasma membrane (PM) formed pinhole‐like invaginations (50 nm in diameter) in the cleaved face (P‐face) of the plasma membrane seen from the outside of the platelets and sharply elevated structures in the cleaved face (E‐face) of PM seen from the inside of the platelts by FEM. The density of OCS on the surface of the platelets from PSS patients was 3 ± 1/μm2, which was higher than that from HC (1 ± 0.5/μm2) (p<0.02). Dome‐shaped structures, which clearly differ from OCS and were 80–150 nm in diameter without intramembranous particles, were seen in the P‐face, and the complementary depressed structures were seen in the E‐face. These structures were thought to be vesicles fused onto the PM of the platelets. The total volume of platelets (7.62 ± 0.11 μm3), total volume of granules (0.79 ± 0.01 μm3) and vacuoles including OCS (0.78 ± 0.05 μm3), and the total surface area of platelets (17.25 ± 1.30 μm2) from four PSS patients calculated by the morphometrical method were similar to those from four HC (7.32 ± 0.25 μm3, 0.76 ± 0.03 μm3, 0.80 ± 0.05 μm3, 18.75 ± 0.35 μm2, respectively); there were no statistical significances between the data from PSS patients and HC. The total volumes of vacuoles in platelets from both PSS patients and HC significantly decreased after a 2 min‐vibration stress of the hands (p<0.02) and the total volume of granules in platelets from PSS patients decreased significantly after the same stress (p<0.002), although that from HC showed no similar significant change. However, there were no statistically significant differences in total volume or total surface of platelets from PSS patients and HC after the stress. These data may suggest that depletion of granules occurred due to activation of platelets from PSS patients following a secretion of their proteins, because their plasma protein levels were elevated after the stress (Jpn J Dermatol, 98; 1205, 1988). Higher density of OCS on the surface of the platelets from PSS patients may play an important role in secretion of their proteins, although the detailed mechanism of secretion of specific proteins derived from platelet granules is still unknown. These ultrastructural abnormalities of platelets may correlate with some involvement of a platelet disorder and with a possible role for the activation of platelets from PSS patients.
Topical Anthralin Therapy for Refractory Nail Psoriasis
Authors: Yamamoto Toshiyuki , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractThe nail is commonly involved in psoriasis; however, very few therapies are satisfactory. In this study, we treated for 20 cases of psoriasis vulgaris with nail involvement with topical anthralin therapy. An ointment of 0.4–2.0% anthralin in petrolatum was applied to the affected nail bed once a day and washed away with water after 30 minutes. Then, 10% triethanolamine cream was applied to prevent undesired pigmentation. Within five months of therapy, twelve out of twenty psoriatic patients (60%) showed moderate and obvious improvement, four patients (20%) showed no response to this regimen. Onycholysis and pachyonychia both responded clinically, and the number of pitting was markedly decreased in some cases. The main side effect of anthralin therapy was reversible pigmentation of the nail plate. Topical anthralin therapy is effective for nail psoriasis and considered to be a useful treatment for refractory nail psoriasis.
Suplatast Tosilate (IPD®), a New Immunoregulator, Is Effective in Vitiligo Treatment
Authors: Nihei Yoshimichi , Nishibu Akiko , Kaneko Fumio 
Published: April 2015

AbstractThe major type of vitiligo is considered to be an autoimmune disorder. Anti‐melanocyte antibodies are frequently detected in sera of patients with this disease. Interleukin (IL)‐4 released from Th2 cells is an important factor in stimulating autoantibody production by B‐cells. In this study, seven patients with vitiligo treated with suplatast tosilate (IPD), three showed repigmentation and improvement of their lesions after administration of the drug. IPD halted the continuous spread of the lesions in three of the other patients, and, in two of them, also reduced microsome test and thyroid test titers. The efficacy of IPD in treating vitiligo was thought to be due to the suppressive effect of this drug on IL‐4 production. No side effect was observed. Thus IPD may represent a new alternative in vitiligo treatment due to its inhibition of autoimmunity by the suppression of IL‐4.
Intralymphatic Embolic Cells with Cutaneous Endometriosis in the Umbilicus
Authors: Ichimiya Makoto , Hirota Toru , Muto Masahiko 
Published: April 2015

AbstractEndometriosis is defined as the presence of both functioning endometrial glands and stroma outside their usual location lining the uterine cavity. It has been identified in virtually all tissues and organs of the female body with the exception of the spleen. There have been many theories proposed regarding the etiology and pathogenesis of endometriosis. One is the transport of cells through lymphatics and blood vessels. A 44‐year‐old female suffering from an episode of endometriosis of the umbilicus, left inguinal, uterus, and bilateral ovaries in association with a Müllerian anomaly is presented. Histopathological findings of a skin biopsy from her umbilicus showed aggregated cells within the lymphatic vessel of the upper dermis. This case provides evidence suggesting that cutaneous endometriosis could occur by transport of endometrial cells through lymphatics or blood vessels.
Epidermal Cytokine mRNA Expression Induced by Hapten Differs from that Induced by Primary Irritant in Human Skin Organ Culture System
Authors: Matsunaga Tsuyoshi , Katayama Ichiro , Yokozeki Hiroo , Nishioka Kiyoshi 
Published: April 2015

AbstractEpidermal cells produce various kinds of cytokines and express cell adhesion molecules. To analyze early events which induced in human epidermis by stimulation with various chemicals, we analyzed mRNA of cytokines expressed in epidermis in a human skin organ culture system. After painting haptens, primary irritants or vehicle control on human skin specimens sliced to 1 mm thickness and cut into approximately 5×5 mm blocks, the pieces were cultured in serum‐free medium. After separating epidermis from dermis, total RNA was extracted and mRNA of cytokines was assessed by the reverse transcriptase‐polymerase chain reaction. Only haptens induced IL‐1β mRNA at 1–3 hours. TNF‐α mRNA was induced 9 hours after application of haptens and 1 hour after application of primary irritants. IL‐1α mRNA was not induced by either haptens or primary irritants. Thus, cytokine mRNA expression induced by haptens in epidermis differs from that induced by primary irritants.
Multiple Cutaneous Epithelioid Hemangioendothelioma: A Case with Spindle Cells
Authors: Kato Naoko , Tamura Ayumi , Okushiba Mikiyo 
Published: April 2015

AbstractA case of multiple cutaneous epithelioid hemangioendothelioma (EH) in a Japanese male is reported. The patient was a 52‐year‐old Japanese bureaucrat. Clinically, about 10 purplish‐red, elastic soft or hard papules and nodules had appeared on both lower extremities and the left buttock over the past 20 years. They were excised, but some of them recurred. Histologically, the papules and nodules were well‐circumscribed tumors located in the superficial and deep dermis. They appeared to arise from medium‐sized vessels and were composed of proliferations of characteristic epithelioid endothelial cells with intracytoplasmic vacuolization and spindle cells. No other extracutaneous tumors were found. We diagnosed the present case as multiple cutaneous EH with spindle cells. The presence of epithelioid endothelial cells and absence of pleomorphism and mitoses of nuclei of spindle cells made differential diagnosis from Kaposi's sarcoma possible. The protracted clinical course seems characteristic of EH in various organs including skin.
Pachyonychia Congenita Associated with Steatocystoma Multiplex
Authors: Kim Joong Uhk , Nogita Toshitatsu , Terajima Satomi , Kawashima Makoto 
Published: April 2015

AbstractWe present an unique case of pachyonychia congenita associated with steatocystoma multiplex. A 33‐year‐old Japanese man had thickening and gray‐brown dicoloration of all nails and a large number of nodules or tumors over his entire skin. No palmar and plantar hyperkeratosis, leukokeratosis of the mucous membranes, or follicular keratosis were observed. Histology of these tumors revealed the typical features of steatocystoma multiplex.
Schönlein‐Henoch Purpura in Association with Duodenal Ulcer and Gastric Helicobacter pylori Infection
Authors: Cecchi Roberto , Torelli Ettore 
Published: April 2015

AbstractWe report a 62‐year‐old man who presented with Schönlein‐Henoch purpura (SHP) associated with duodenal ulcer and gastric Helicobacter pylori (HP) infection. The recurrent purpuric rash faded after HP eradication with amoxycillin, clarythromycin, and omeprazole treatment. These findings suggest a causative role for HP in the occurrence of SHP.
The Levels of Plasma Interleukin‐2 and Soluble Interleukin‐2R in Behçet's Disease: A Marker of Disease Activity
Authors: Çayirli Erkan Alpsoy Çiçek , Er Hanife , Yilmaz Ertan 
Published: April 2015

AbstractIt is well known that patients with Behçet's disease (BD) have an activated immune system, probably mediated by soluble factors in the circulation. The purpose of our study was to examine the roles of plasma interleukin‐2 (IL‐2) and soluble interleukin‐2 receptor (sIL‐2R) in the pathogenesis of BD.Thirty‐two patients with BD diagnosed according to the Criteria of the International Study Group for Behçet's Disease and 20 age‐matched healthy persons were included in the study. The plasma levels of cytokines were measured by ELISA.Plasma levels of IL‐2 and sIL‐2R were increased in BD over controls, but the differences were not statistically significant. sIL‐2R levels in patients with active disease were significantly higher than in either patients with inactive disease (p<0.001) or the control group (p<0.05).Our results suggest that the level of sIL‐2R in BD seems to be related to disease activity.
Pruritus Gravidarum: A Clinical and Laboratory Study
Authors: Shanmugam Srikanth , Thappa Devinder Mohan , Habeebullah Syed 
Published: April 2015

AbstractFive hundred pregnant women attending obstetrics OPD were screened for the presence of pruritus. The patients with other dermatological causes of pruritus (other than specific dermatosis of pregnancy) were excluded from the study. The selected patients were further subjected to routine laboratory investigations including liver function tests and HBs Ag detection. The prevalence of pruritus in pregnancy was found to be 4.6% (23 cases). Ten patients were found to have specific dermatoses of pregnancy, including four cases of pruritus gravidarum and four of pruritic urticarial papules and papules of pregnancy. The prevalence of pruritus gravidarum was 0.8% of pregnancies. All the patients with pruritus gravidarum were primigravidae and had no clinical overlap with other specific dermatoses of pregnancy, jaundice, or intrahepatic cholestasis. One case of perinatal death was recorded among the pruritus gravidarum cases. This study has been helpful in determining the prevalence and severity of pruritus gravidarum in South India.
Acquired Reactive Perforating Collagenosis with IgA Nephropathy
Authors: Iwamoto Ikuyo , Baba Shunichi , Suzuki Hiroyuki 
Published: April 2015

AbstractA 25‐year‐old Japanese man developed numerous discrete umbilicated papules on his face, trunk, and both forearms at the onset of IgA nephropathy. The newest lesion was a nonumbilicated skin‐colored papule. On histopathologic examination, alteration of capillaries was observerd in both newer and umbilicated papules. In our case, a primary cause of the reactive perforating collagenosis could be an alteration of the capillaries.
Flame Figures Associated with Bullous Pemphigoid
Authors: Watanabe Hideaki , Sueki Hirohiko , Kitami Amane , Kakuchi Chikako , Ikeda Yusuke , Nagata Shigeki , Hashimoto Takashi , Iijima Masafumi 
Published: April 2015

AbstractWe report a case of bullous pemphigoid showing the histological features of flame figures. An 80‐year‐old man was admitted with multiple, tense, thumb‐sized blisters among erythematous plaques on his trunk and limbs. A biopsy showed accumulations of eosinophil granules on the collagen fibers, forming characteristic “flame figures”, in addition to the features of bullous pemphigoid. We retrospectively examined biopsy specimens from 34 patients with bullous pemphigoid treated in our department over the last 10 years for the presence of flame figures. They were observed in 3 of these patients (8.8%), all of whom were more than 80 years of age. Our retrospective study indicates that the association of flame figures with bullous pemphigoid is not rare, considering the fact that the present case is only the third report of this association. Our data also suggest that the degree of dermal eosinophilia and the formation of flame figures could be related.
Necrobiosis Lipoidica‐like Skin Lesions in Systemic Sarcoidosis
Authors: Igawa Ken , Maruyama Ryuji , Satoh Takahiro , Yokozeki Hiroo , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractA 62‐year‐old woman with systemic sarcoidosis developed erythematous plaques on her lower legs. Clinically, two kinds of skin lesions were distinguished; one type formed brownish‐red plaques with induration suggesting plaque‐type skin sarcoid, and the other formed purplish erythematous plaques with atrophic centers resembling necrobiosis lipoidica. In spite of this clinical appearance, a biopsy specimen from one of the latter lesions revealed typical skin sarcoid histology composed of discrete non‐caseating granulomas, while that from one of the other lesions showed necrobiotic changes of collagen bundles surrounded by epitheloid histiocytes and foreign‐body giant cells. Because cutaneous involvement of sarcoidosis may mimic necrobiosis lipoidica clinically and/or histologically, we diagnosed her skin lesions as necrobiosis‐like skin sarcoid.
A Case of Carotenodermia Caused by a Diet of the Dried Seaweed Called Nori
Authors: Nishimura Yurika , Ishii Norihisa , Sugita Yasuyuki , Nakajima Hiroshi 
Published: April 2015

AbstractCarotenodermia may arise from excessive dietary intake of carotene containing foods. We reported a 22‐year‐old woman who had eaten excessive amount of carotene‐rich seaweed to lose weight. Her skin color changed to orange‐yellow, and her serum β‐carotene was 573 μg/dl. After stopping the ingestion of seaweed, her skin color returned to normal.
Combination Therapy with Low‐Dose Etretinate and Eicosapentaenoic Acid for Psoriasis Vulgaris
Authors: Danno Kiichiro , Sugie Nobuo 
Published: April 2015

AbstractA randomized open study was undertaken to compare the therapeutic effects between low‐dose etretinate alone and low‐dose etretinate combined with eicosapentaenoic acid in 40 patients with chronic, stable psoriasis vulgaris. Better and more rapid improvement was obtained with the combination therapy for 12 weeks than with low‐dose etretinate monotherapy. Eicosapentaenoic acid was safe, and adverse reactions due to low‐dose etretinate were mild or tolerable. The combination regimen, therefore, has a satisfactory effect on psoriasis without marked adverse reactions.
A Case of Pre‐Sézary Syndrome Preceded by Hand Lesions
Authors: Lee Nam Ho , Lee Se‐Won , Choi Eung Ho , Lee Won‐Soo , Ahn Sung Ku 
Published: April 2015

AbstractPre‐Sézary syndrome is an erythroderma with a chronic course, clinical findings of Sézary syndrome, lymphocytic subepidermal band infiltration at times, and repeated cycles of circulating Sézary cells of less than 1,000 cells/mm3. Duration of the pre‐existing skin diseases preceding pre‐Sézary erythroderma varies from a few weeks to 20 years. Before the erythroderma develops, these patients are diagnosed with contact dermatitis, neurodermatitis, chronic dermatitis, atopic dermatitis, or asteatotic eczema. Hand lesion also precedes the pre‐Sézary erythroderma. This condition has been controlled by three cycles of chemotherapy consisting of vincristine, Cytoxan, doxorubicin, and prednisolone. We describe a case of pre‐Sézary syndrome preceded by hand lesion and treated with chemotherapy.