bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase 2 study of ipatasertib in combination with pembrolizumab for first-line treatment of recurrent or metastatic squamous cell cancer of the head and neck.
Authors: Thomas Jacob Stephen , Yang Bruce Justine , Li Zujun , Lorch Jochen H. , Phillips Tanyanika , Villaflor Victoria , Ruel Christopher , Palmer Joycelynne , Gutkind J. Silvio , Villalona-Calero Miguel Angel , Colevas Alexander Dimitrios 
Published: July 2024

TPS6117 Background: Single agent pembrolizumab in relapsed / metastatic head and neck squamous cell carcinoma (R/M HNSCC) has an estimated ORR of 19% and median OS of 13.6 months. There are several factors which may influence which patients respond to antibodies targeting the PD-1 axis. Regulatory T cells (Tregs) play a significant role in an immunosuppressive tumor microenvironment. Anti-PD-1 antibodies induce Treg activation in part through AKT pathway activation, which may contribute to low response rates to checkpoint inhibitor therapy. AKT blockade selectively inhibits the proliferation of human Tregs. Additionally, inhibition of the PI3K-AKT-mTOR pathway limits myeloid-derived suppressor cells (MDSC) infiltration and differentiation, and boosts CD8+ T cell memory and effector function. Ipatasertib is an oral highly selective small-molecule inhibitor of all three isoforms of AKT. This phase 2 trial is designed to compare progression-free survival (PFS) in first line R/M, HNSCC patients treated with the combination ipatasertib and pembrolizumab versus pembrolizumab monotherapy treatment. Methods: In this open-label randomized phase 2 multicenter trial, patients with R/M HNSCC are treated with pembrolizumab 200mg on day 1 +/- ipatasertib 400mg QD days 1-14 of 21-day cycles. Patients must have PD-L1 CPS score ³ 1, have measurable disease per RECIST 1.1, and consent to on-treatment biopsy. Patients will be excluded if they have received prior systemic therapy for R/M HNSCC, cannot swallow a pill, or require insulin for diabetes. The primary objective is to compare the PFS between the two arms. We will estimate the relative hazard ratio associated with ipatasertib plus pembrolizumab compared to pembrolizumab alone using the Cox Model where randomized treatment assignment is the only variable in the model. Secondary objectives include ORR, safety and tolerability of the combination, and changes in tumor immune cell infiltration, AKT signaling, and changes in peripheral blood immune cells. Ultimately, a total of 48 patients will be enrolled, with 24 patients in each cohort. To date, a total of 22 patients have been enrolled from 15 sites. Accrual is ongoing (NCT05172258). Clinical trial information: NCT05172258 .
eVOLVE-HNSCC: A global phase 3 study of volrustomig as sequential therapy for unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) following definitive concurrent chemoradiotherapy (cCRT).
Authors: Haddad Robert I. , Ruscica Dario , Visa Alexandra , Li Xia , Licitra Lisa F. 
Published: July 2024

TPS6120 Background: Currently there are no approved maintenance therapies for patients (pts) with unresected LA-HNSCC following definitive cCRT. The PD-1 inhibitors pembrolizumab and nivolumab are licensed for treatment of pts with recurrent or metastatic HNSCC who have progressed on or after a platinum-based therapy. Dual inhibition of CTLA-4 and PD-L1 is approved in solid tumors including renal cell carcinoma (RCC), NSCLC, and melanoma, and has shown a numerical trend towards improved survival in first-line pts with recurrent/metastatic HNSCC whose tumors express PD-L1. Volrustomig (MEDI5752) is a monovalent, PD-1/CTLA-4 bispecific, humanized IgG1 monoclonal antibody engineered to specifically inhibit PD-1, with increased CTLA-4 blockade on PD-1+ activated T cells compared to PD-1– resting peripheral T cells. In a first-in-human phase 1/2 study (NCT03530397), volrustomig monotherapy showed promising efficacy with acceptable tolerability in advanced clear cell RCC and in combination with chemotherapy in advanced NSCLC. The phase 3, randomized, open-label, multicenter, eVOLVE-HNSCC study will evaluate the efficacy and safety of sequential therapy with volrustomig compared with observation in pts with unresected LA-HNSCC who have not progressed after receiving definitive cCRT (NCT06129864). Methods: Key eligibility criteria include histologically or cytologically confirmed, unresected LA-HNSCC with no evidence of metastatic disease, i.e. AJCC 8th edition (TNM staging system) stage IVA/B cancers of the hypopharynx, oral cavity, larynx or HPV-negative oropharynx, or stage III HPV-positive oropharynx cancer; age ≥18 years; WHO/ECOG performance score of 0 or 1; and adequate organ and bone marrow function. Key exclusion criteria include requiring further treatment with curative intent after definitive cCRT, resected LA-HNSCC, recurrent/metastatic disease, and >1 primary tumor. Following initial screening and definitive cCRT (cisplatin or carboplatin + paclitaxel or carboplatin + 5-FU, plus concomitant radiotherapy), approximately 1145 pts whose disease has not progressed within 12 weeks of the last dose of cCRT will be randomized 1:1 to Arm A or B. Arm A will receive volrustomig intravenously every 3 weeks for a maximum of 12 months or 18 cycles, or until RECIST v1.1-defined radiological progressive disease (PD) or unacceptable toxicity. Arm B will undergo observation for a maximum of 12 months or until PD. The primary endpoint is PFS in pts with PD-L1-expressing tumors. Secondary endpoints include PFS in all randomized pts, OS in pts with PD-L1-expressing tumors and in all randomized pts, PFS2, safety, patient-reported outcomes, pharmacokinetics, and immunogenicity. Exploratory biomarker analyses will also be conducted. Enrollment began in December 2023. Clinical trial information: NCT06129864 .
Association Between Social Determinants of Health and Cancer Treatment Delay in an Urban Population
Authors: Zhang Faye G. , Sheni Risha , Zhang Chenxin , Viswanathan Shankar , Fiori Kevin , Mehta Vikas 
Published: July 2024

PURPOSE
Delays in oncologic time to treatment initiation (TTI) independently and adversely affect disease-specific mortality. Social Determinants of Health (SDoH) are increasingly recognized as significant contributors to patients' disease management and health outcomes. Our academic center has validated a 10-item SDoH screener, and we elucidated which specific needs may be predictive of delayed TTI.

METHODS
This is a retrospective cohort study at an urban academic center of patients with a SDoH screening and diagnosis of breast, colorectal, endocrine/neuroendocrine, GI, genitourinary, gynecologic, head and neck, hematologic, hepatobiliary, lung, or pancreatic cancer from 2018 to 2022. Variables of interest included household income, tumor stage, and emergency department (ED) or inpatient admission 30 days before diagnosis. Factors associated with delayed TTI ≥45 days were assessed using multivariable logistic regression.

RESULTS
Among 2,328 patients (mean [standard deviation] age, 64.0 (12.8) years; 66.6% female), having >1 unmet social need was associated with delayed TTI (odds ratio [OR], 1.68; 95% CI, 1.54 to 1.82). The disparities most associated with delay were legal help, transportation, housing stability, and needing to provide care for others. Those with ED (OR, 0.49; 95% CI, 0.44 to 0.54) or inpatient (OR, 0.54; 95% CI, 0.50 to 0.58) admission 30 days before diagnosis were less likely to experience delay.

CONCLUSION
Delays in oncologic TTI ≥45 days are independently associated with unmet social needs. ED or inpatient admissions before diagnosis increase care coordination, leading to improved TTI. Although limitations included the retrospective nature of the study and self-reporting bias, these findings more precisely identify targets for intervention that may more effectively decrease delay. Patients with SDoH barriers are at higher risk of treatment delay and could especially benefit from legal, transportation, caregiver, and housing assistance.
Breeding Place Preference of Aedes sp. at the Tsunami Area Banda Aceh City
Authors: Agustina Elita , Emil Muhammad Farhan Putra 
Published: July 2024

The rebuilding of the post-tsunami community residential in Banda Aceh has had an impact on the emergence of Aedes habitat. The Aedes choose a container to breed based on biotic and abiotic factors that support their survival. This study aimed to the identification of Aedes species, location and type positive containers Aedes larvae at the area tsunami Banda Aceh. Methods an observational study of a cross-sectional approach involved 100 houses. Data larvae were collected using the single larvae method. Observations of containers were carried out in natural and artificial containers, indoors and outdoors. Positive containers Aedes larvae were recorded for the type of container and location found. The result of the study found two species of Aedes, there were Aedes aegypti and Aedes albopictus. Larvae of Ae. aegypti was generally found in containers indoors (71%) and containers outdoors (29%). Larvae of Ae. albopictus were found in containers indoors (10%) and containers outdoors (90%). The types of positive breeding containers of Ae. aegypti found were bathtubs (71%), discarded tires (9%), plastic drums (5%), water tanks (5%), watering pots (5%) and flower pots (5%). The containers were observed found larvae of Ae. albopictus were the bucket (30%), plastic drum (20%), bathtub (10%), discarded tires (10%), pet drinking place (10%), mineral water jar (10%) and coconut shells (10%). Monitoring of containers indoors and outdoors that can hold water is important supports the eradication program breeding places of Ae. aegypti and Ae. albopictus.
Laser biospeckle method for a fast and reliable microbioassay
Authors: Devi Arti , Kadono Hirofumi , Rajagopalan Uma Maheswari 
Published: July 2024

Recently, the direct toxicity assessment (DTA) approach or bioassay has attracted much attention, as it can comprehensively evaluate water toxicity without examining a specific/individual chemical component. Bioassays are used to investigate how organisms respond to pollutants compared to controls. In this technique, a microscopic observation is required to know the critical features such as alive/dead, and swimming ability of microorganisms. As the size of the microorganism becomes smaller, observation becomes more difficult due to the narrower focal depth of the imaging system. In our study, to overcome the difficulties, we propose, to our knowledge, a novel technique for the microbioassay utilizing a biospeckle in the diffraction field generated from its movement. We employed Paramecia caudatum sized around 200–300 µm. The sample cell containing Paramecia was illuminated with a laser light with a diameter 15 mm and wavelength 635 nm. The specular component of the transmitted light was filtered out using a spatial filter placed at the Fourier plane and the biospeckle patterns in the diffraction field were acquired using a CCD camera as a movie. It is obvious that the dynamic properties of the biospeckle precisely reflects the movement of the scattering particles or Paramecia. Paramecia were exposed to HCl solutions with pH7.1, control, to 3.7 where all were dead. The swimming abilities of the Paramecia were successfully evaluated based on the crosscorrelation function of the frames of biospeckle patterns. The advantage of the method is that, owing to the non-imaging system, an enormous number of Paramecia can be processed as a whole, and a statistically significant estimation of the swimming ability of Paramecia under the influence of environmental pollution can be derived immediately.
The global impact of COVID-19 on tuberculosis: A thematic scoping review, 2020–2023
Authors: Marco Michael H. , Ahmedov Sevim , Castro Kenneth G. 
Published: July 2024

Background
This thematic scoping review of publications sought to understand the global impact of COVID-19 on tuberculosis (TB), interpret the scope of resonating themes, and offer policy recommendations to stimulate TB recovery and future pandemic preparedness.

Data sources
Publications were captured from three search engines, PubMed, EBSCO, and Google Scholar, and applicable websites written in English from January 1, 2020, to April 30, 2023.

Study selection
Our scoping review was limited to publications detailing the impact of COVID-19 on TB. Original research, reviews, letters, and editorials describing the deleterious and harmful––yet sometimes positive––impact of COVID-19 (sole exposure) on TB (sole outcome) were included. The objective was to methodically categorize the impacts into themes through a comprehensive review of selected studies to provide significant health policy guidance.

Data extraction
Two authors independently screened citations and full texts, while the third arbitrated when consensus was not met. All three performed data extraction.

Data synthesis/Results
Of 1,755 screened publications, 176 (10%) covering 39 countries over 41 months met the inclusion criteria. By independently using a data extraction instrument, the three authors identified ten principal themes from each publication. These themes were later finalized through a consensus decision. The themes encompassed TB’s care cascade, patient-centered care, psychosocial issues, and health services: 1) case-finding and notification (n = 45; 26%); 2) diagnosis and laboratory systems (n = 19; 10.7%) 3) prevention, treatment, and care (n = 22; 12.2%); 4) telemedicine/telehealth (n = 12; 6.8%); 5) social determinants of health (n = 14; 8%); 6) airborne infection prevention and control (n = 8; 4.6%); 7) health system strengthening (n = 22; 13%); 8) mental health (n = 13; 7.4%); 9) stigma (n = 11; 6.3%); and 10) health education (n = 10; 5.7%).

Limitations
Heterogeneity of publications within themes.

Conclusions
We identified ten globally generalizable themes of COVID-19’s impact on TB. The impact and lessons learned from the themed analysis propelled us to draft public health policy recommendations to direct evidence-informed guidance that strengthens comprehensive global responses, recovery for TB, and future airborne pandemic preparedness.
Etnografía e intervención: posiciones, colabor y horizontes de extensión en una investigación con jóvenes en y fuera de una escuela
Authors: Marioni Lucía 
Published: July 2024

Reflexiono sobre la oportunidad que una investigación etnográfica significó para el desarrollo de una serie de prácticas de intervención y sobre sus posibles vínculos con la extensión. Busco responder —deforma situada— cómo se procesan sus lógicas y horizontes diferentes y cómo la primera puede significar un aporte a la segunda. Parto del análisis de registros de dos trabajos de campo con jóvenes de la periferia de Paraná en el marco de planes detrabajo como investigadora del Instituto de Estudios Sociales de la Universidad Nacional de Entre Ríos y del Consejo Nacional deInvestigaciones Científicas y Técnicas y revisito un recorrido como extensionista en el Área de Comunicación Comunitaria dela Facultad de Ciencias de la Educación de dicha Universidad. Propongo la perspectiva etnográfica como oportunidad y escenariopara una práctica de intervención que, realizada por una trabajadora del sistema científico–universitario, puede ingresar al ámbito de la extensión.
Application of Student-Centered Learning Model in Guidance and Counseling Course for Students
Authors: Purnika Sari Nia Juwita , Dwi Ratnasari  , Sri Purnami  
Published: July 2024

Among the student-centered approaches, there is one that stands out: student-centered learning (SCL). This model emphasizes students' ability to learn and make decisions. This research uses a qualitative approach with a case study method; examining how the student-centered learning paradigm is applied in the field of guidance and counseling is the main objective of this research. The informants in this study were field study students in the Islamic Education Program at UIN Sunan Kalijaga Yogyakarta during the period October–November 2023. The students involved were all registered in the guidance and counseling course. Data collection techniques include observation and interviews. Based on the results of the study, it was concluded that the application of the student-centered learning model in guidance and counseling classes B and C in the odd semester of 2023 proved effective in increasing student activeness. The increase in student activity can be seen in the increase in critical thinking skills, communication skills, and skills in solving problems. In addition, the lecturer acts as a facilitator of learning practices and is responsible for overseeing the entire learning process.

Abstrak
Diantara pendekatan yang berpusat pada siswa, ada satu yang menonjol: Pembelajaran Berpusat pada Siswa (SCL). Model ini menekankan pada kemampuan siswa dalam pembelajaran dan pengambilan keputusan terkait pertumbuhan. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus, mengkaji bagaimana paradigma pembelajaran yang berpusat pada siswa diterapkan dalam bidang bimbingan dan konseling menjadi tujuan utama penelitian ini. Informan dalam penelitian ini merupakan mahasiswa studi lapangan di Program Pendidikan Agama Islam UIN Sunan Kalijaga Yogyakarta selama periode Oktober–NNovember 2023. Mahasiswa yang terlibat semuanya terdaftar pada mata kuliah Bimbingan dan Konseling. Teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Berdasarkan hasil penelitian, diperoleh kesimpulan bahwa penerapan model Student-Centered Learning pada kelas Bimbingan dan Konseling B dan C pada semester ganjil tahun 2023 terbukti efektif dalam meningkatkan keaktifan mahasiswa. Peningkatan aktivitas mahasiswa dapat dilihat dari meningkatnya keterampilan berpikir kritis, keterampilan berkomunikasi, dan keterampilan dalam memecahkan masalah. Disamping itu, dosen berperan sebagai fasilitator praktik pembelajaran yang bertanggung jawab mengawasi seluruh rangkaian pembelajaran.
“Here, We Investigate If There Is …”: A Functional Investigation of Self-Mentions in Research Article Abstracts
Authors: Akbaş Erdem , Dağdeviren-Kirmizi Gülin , Kirmizi Özkan 
Published: July 2024

Abstract
The present study explored authorial presence in the abstracts across three purpose-built discipline-specific corpora of RAs in major but relatively less represented disciplines in corpus studies: Civil Engineering (CE), Political Sciences (PS) and Veterinary Medicine (VM). In particular, due to less attention having been paid to these fields, we examined explicit authorial references with a functional perspective in a corpus of abstracts totaling over one million words. To this end, we first conducted a preliminary search for explicit third-person plural author references in the corpora and manually analysed a total of over 6,000 instances to check if they were all markers signaling an authorial presence in the text. Following this, the second manual analyses concentrated on categorizing the rhetorical functions of self-mentions based on Xia’s (2018) framework. The preliminary findings showed that the frequency of “we”-based authorial references in PS outweighed that in the other disciplines (PS: 722.13; CE: 636.81; VM: 481.30 per 100,000 words). Regarding the density of authorial references, we found that each discipline favored being more visible with divergent authorial roles in their abstracts. For example, PS were more rhetorically present in their abstracts by “proposing a theory or approach” whereas CE and VM authors used fewer self-mentions to mark their presence frequently with this rhetorical device. With respect to the functional analyses of the self-mentions of “we”, all three disciplines displayed more low-stakes functions such as “recount experimental procedure and methodology”. We focused on the significance of cross-disciplinary and functional analysis in the study in order to contribute to designing activities in EAP for each discipline.
Metadiscourse in MOOC Video Lectures: Comparison with University Lectures and Disciplinary Variation
Authors: Yu Xiaoli 
Published: July 2024

Abstract
Based on Hyland’s (2018) interpersonal model of metadiscourse, this study explores MOOC video lecturers’ use of metadiscourse and compares it to traditional university lecturers’. Disciplinary variation in metadiscourse in the MOOC video lectures has also been investigated. The MOOC corpus consists of sixteen MOOCs across three disciplinary areas, including Arts and Humanities, Engineering and Physical Sciences, and Social Sciences. The results suggest that despite slight differences, the most frequently appearing metadiscourse in the MOOC corpus resembles the patterns found in university lectures, which reveals the remarkable similarities in using metadiscourse between MOOCs and traditional face-to-face lectures. However, different instructional contexts and teacher-student relationships indeed contribute to the variance in the employment of metadiscourse. Overall, MOOC video lecturers employed more interactive metadiscourse but less interactional metadiscourse than university lecturers. Cross-disciplinarily, the use of metadiscourse in MOOC video lectures is considerably influenced by disciplinary features. MOOCs containing more discipline-specific content and requiring intensive cognitive effort tend to use more interactive metadiscourse and engagement markers; while for MOOCs that may include more perspectives than basic facts, boosters and attitude markers seem to be employed more frequently. Possible reasons and purposes of the differentiated use of metadiscourse across disciplines are discussed in detail.
Lehrkräftebildner und -bildnerinnen im Modul „Deutsch für Schülerinnen und Schüler mit Zuwanderungsgeschichte“ zwischen institutionellen Vorgaben, individuellen Vorstellungen und zielgruppenspezifischen Bedarfen
Authors: Berkel-Otto Lisa 
Published: July 2024

Zusammenfassung
Zur Weiterentwicklung des an den Hochschulen Nordrhein-Westfalens zum festen Bestandteil der Lehrkräftebildung gehörenden Moduls „Deutsch für Schülerinnen und Schüler mit Zuwanderungsgeschichte“ (DSSZ), beispielsweise durch die Schaffung von mehr Lerngelegenheiten, muss der Status quo des Moduls ermittelt und beschrieben werden. Der Beitrag fokussiert deshalb auf die bisweilen wenig beachtete Gruppe der im Modul tätigen Hochschullehrenden. Aufgrund des durch die Rahmenbedingungen des Moduls (Zielgruppe, Umfang etc.) entstehenden Spannungsverhältnisses drängt sich die Frage auf, wie die Lehrenden im Modul mit diesen Anforderungen umgehen, welche Faktoren sie fokussieren und welche gruppenspezifischen Gemeinsamkeiten und Unterschiede sich daraus ergeben. In einer qualitativen Inhaltsanalyse problemzentrierter Interviews mit zwanzig Modullehrenden an zwei Standorten A und B zeigen sich vor allem fächergruppenspezifische Unterschiede. Eine anschließende Typenbildung liefert Hinweise darauf, dass die Modullehrenden überwiegend individuen- und zielgruppenspezifisch handeln und sich gleichzeitig in einem Kontext bewegen, in dem sie permanent durch den eng gesteckten Modulrahmen evozierte Entscheidungen treffen müssen.