bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of landslide-prone areas in Tripe Jaya district, Gayo Lues Regency
Authors: Murdawati  , Nizamuddin  , Fatimah E 
Published: July 2024

Abstract
Tripe Jaya District is one of the sub-districts of Gayo Lues regency, which has hilly and mountainous morphological areas with steep slopes and landslides in several regions of the road area. This study aims to identify and map the location of landslides and analyze landslide areas. A quantitative method for measuring landslide-prone levels from the Center for Volcanology and Geological Hazard Mitigation 2005, the method used is the score and weight of the parameters that cause landslide-prone. The causes of landslide-prone sites are rainfall data, soil type, elevation, land use, and slope. The results of this study have five classes of landslide vulnerability, including very low landslide vulnerability level covering an area of 279.21 Ha (1%), low vulnerability level covering an area of 3639.80 Ha (9%), medium vulnerability level covering an area of 17893.07 Ha (43%), high vulnerability level covering an area of 19822.91 Ha (47%), and very high vulnerability level covering an area of 150.23 Ha (0.36%). Landslide events in Tripe Jaya District based on field observations, there are landslide events in high and very high classes. This research provides an overview of landslide-prone areas so the results of the study can be used as a basis for planning mitigation strategies and as a consideration for the government in building the required mitigation developing mitigation measures related to landslide-prone risks in the Tripe Jaya.
Deaf space concept in designing classroom interior for learning motivation of deaf students in special schools
Authors: Humam M K , Kahfi S , Andryansyah R , Taqiuddin Z , Bashair F , Rida M R 
Published: July 2024

Abstract
Deaf children, individuals with hearing limitations, require a supportive environment for effective communication. Regular classrooms, designed for typically hearing children, present communication challenges for deaf students. Deaf classrooms follow specific principles and approaches known as “deaf space,” including furniture arrangement, larger spaces, sensory accessibility, lighting, and color choices. This research aims to design a classroom that creates a comfortable atmosphere for deaf students to enhance their oral communication and learning. The study utilizes a mixed-method approach, combining qualitative and quantitative methods. Classroom simulations were conducted to observe and compare the responses of deaf students in both regular classrooms and those designed with a “deaf space” approach. Simulation results revealed changes in learning activities and oral communication among deaf students. Deaf students responded positively and expressed satisfaction with the layout of the learning space and furniture aligned with the “deaf space” concept. The choice of a calming green color enhanced the comfort of deaf students during learning, allowing for better focus. The final classroom design provides a solution to address existing classroom challenges, accommodating the needs and activities of users. This design is expected to motivate the learning interests of deaf children while serving as a guide for planning and implementation.
The tribological properties of PPS-PTFE/SiO2 coating deposited on the textured surfaces processed by ultrasonic rolling
Authors: Wu Jiaxing , Deng Jianxin , Zhang Zhihui , Bao Yichen 
Published: July 2024

Abstract
In this paper, ultrasonic rolling textures were fabricated on 42CrMo steel substrates, and the polyphenylene sulfide-polytetrafluoroethylene/silicon dioxide (PPS-PTFE/SiO2) lubricating coatings were deposited on the textured surfaces to improve the tribological properties of the coating-substrate system. The influences of textures with different shapes (spiral, linear, wavy textures) and step distances (100, 150, 200, 250 μm) on the surface morphologies and strengthening effects of the substrates were investigated. The results showed the wavy texture with a step distance of 200 μm had the best strengthening effect, which increased the surface hardness and residual compressive stress by 126.1% and 5.1 times compared to the substrate, respectively. The influences of different textures on the friction and wear properties of lubricating coatings were studied by dry reciprocating friction testings. The results showed that the coating on the spiral textured surface with a step distance of 250 μm had the best tribological properties, and the average friction coefficient and wear rate were reduced by 45.5% and 49.5% compared to the coating on the substrate. The influence of ultrasonic rolling texture on the tribological properties of the lubricating coating was a combined result of the strengthening effect and texture structure. The strengthening effect provided a steady gain, while the texture structure provided either a gain or a deterioration.
Physical computing: a category theoretic perspective on physical computation and system compositionality
Authors: Dehghani Nima , Caterina Gianluca 
Published: July 2024

Abstract
This paper introduces a category theory-based framework to redefine physical computing in light of advancements in quantum computing and non-standard computing systems. By integrating classical definitions within this broader perspective, the paper rigorously recontextualizes what constitutes physical computing devices and processes. It demonstrates how the compositional nature and relational structures of physical computing systems can be coherently formalized using category theory. This approach not only encapsulates recent formalisms in physical computing but also offers a structured method to explore the dynamic interactions within these systems.
Early-life famine exposure may modify the association between long-term temperature variability and cardio-cerebrovascular diseases: a nationwide study
Authors: Wu Yao , Su BinBin , Xie Junqing , Wen Bo , Wu Xiaolan , Wang Mengfan , Dong Yanhui , Song Yi , Ma Jun 
Published: July 2024

Abstract
We aimed to evaluate whether the association between long-term temperature variability (TV) and cardio-cerebrovascular diseases (CCVDs) was affected by famine exposure in different age stages. We used data from the fourth national urban and rural elderly population survey (2015). Participants were categorized into six groups based on their age at famine exposure (famine exposure under age 5, between ages 5 and 18, and during adulthood) and the severity (severely affected areas versus mildly affected areas) of the Great Chinese Famine (1959–1961) in their province of residence. Mixed-effects logistic regression model was used to quantify the association between long-term TV and the prevalence of CCVDs across six famine-exposed groups. A total of 222 179 participants were included. In severely affected areas, the odds ratio (OR) of CCVDs associated with per 1 °C increase in 5 year average TV were 1.07 (95% confidence interval [CI]: 1.02, 1.13) for those exposed to famine during adulthood, 1.28 (95% CI: 1.17, 1.40) under the age of 5 years. Urban residence, higher education, increased household income, and more frequent physical activity could mitigate the association between TV and CCVDs, particularly among those exposed to severe famine before the age of 5. Individuals exposed to famine before the age of 5 are more susceptible to TV-related CCVDs compared to those exposed during adulthood. Our findings highlight the importance of early-life nutrition in lowering susceptibility to CCVDs later in life.
Estimating dementia incidence in insured older Asian Americans and Pacific Islanders in California: an application of inverse odds of selection weights
Authors: Hayes-Larson Eleanor , Zhou Yixuan , Wu Yingyan , Rojas-Saunero L Paloma , Seamans Marissa J , Gee Gilbert C , Brookmeyer Ron , Gilsanz Paola , Whitmer Rachel A , Mayeda Elizabeth Rose 
Published: July 2024

Abstract
Literature shows heterogeneous age-standardized dementia incidence rates across US Asian American, Native Hawaiian, and Pacific Islanders (AANHPI), but no estimates of population-representative dementia incidence exist due to lack of AANHPI longitudinal probability samples. We compared harmonized characteristics between AANHPI Kaiser Permanente Northern California members (KPNC cohort) and the target population of AANHPI 60+ with private or Medicare insurance using the California Health Interview Survey. We used stabilized inverse odds of selection weights (sIOSW) to estimate ethnicity-specific crude and age-standardized dementia incidence rates and cumulative risk by age 90 in the target population. Differences between the KPNC cohort and target population varied by ethnicity. The sIOSW eliminated most differences in larger ethnic groups; some differences remained in smaller groups. Estimated crude dementia incidence rates using sIOSW (vs unweighted) were similar in Chinese, Filipinos, Pacific Islanders and Vietnamese, and higher in Japanese, Koreans, and South Asians. Unweighted and weighted age-standardized incidence rates differed for South Asians. Unweighted and weighted cumulative risk were similar for all groups. We estimated the first population-representative dementia incidence rates and cumulative risk in AANHPI ethnic groups. We encountered some estimation problems, and weighted estimates were imprecise, highlighting challenges using weighting to extend inferences to target populations.
Could differential underreporting of loneliness between men and women bias the gender-specific association between loneliness duration and rate of memory decline? A probabilistic bias analysis of effect modification
Authors: Yu Xuexin , Zahodne Laura B , Gross Alden L , Needham Belinda L , Langa Kenneth M , Cho Tsai-Chin , Kobayashi Lindsay C 
Published: July 2024

Abstract
Gender is an observed effect modifier of the association between loneliness and memory aging. However, this effect modification may be a result of information bias due to differential loneliness underreporting by gender. We applied probabilistic bias analyses to examine whether effect modification of the loneliness–memory decline relationship by gender is retained under three simulation scenarios with various magnitudes of differential loneliness underreporting between men and women. Data were from biennial interviews with adults aged ≥ 50 years in the US Health and Retirement Study from 1996-2016 (5646 women and 3386 men). Loneliness status (yes vs no) was measured from 1996-2004 using the Center for Epidemiologic Studies Depression (CES-D) Scale loneliness item, and memory was measured from 2004-2016. Simulated sensitivity and specificity of the loneliness measure were informed by a validation study using the UCLA Loneliness Scale as a gold standard. The likelihood of observing effect modification by gender was higher than 90% in all simulations, although the likelihood reduced with an increasing difference in magnitude of the loneliness underreporting between men and women. The gender difference in loneliness underreporting did not meaningfully affect the observed effect modification by gender in our simulations. Our simulation approach may be promising to quantify potential information bias in effect modification analyses.
DrugMetric: quantitative drug-likeness scoring based on chemical space distance
Authors: Li Bowen , Wang Zhen , Liu Ziqi , Tao Yanxin , Sha Chulin , He Min , Li Xiaolin 
Published: July 2024

Abstract
The process of drug discovery is widely known to be lengthy and resource-intensive. Artificial Intelligence approaches bring hope for accelerating the identification of molecules with the necessary properties for drug development. Drug-likeness assessment is crucial for the virtual screening of candidate drugs. However, traditional methods like Quantitative Estimation of Drug-likeness (QED) struggle to distinguish between drug and non-drug molecules accurately. Additionally, some deep learning-based binary classification models heavily rely on selecting training negative sets. To address these challenges, we introduce a novel unsupervised learning framework called DrugMetric, an innovative framework for quantitatively assessing drug-likeness based on the chemical space distance. DrugMetric blends the powerful learning ability of variational autoencoders with the discriminative ability of the Gaussian Mixture Model. This synergy enables DrugMetric to identify significant differences in drug-likeness across different datasets effectively. Moreover, DrugMetric incorporates principles of ensemble learning to enhance its predictive capabilities. Upon testing over a variety of tasks and datasets, DrugMetric consistently showcases superior scoring and classification performance. It excels in quantifying drug-likeness and accurately distinguishing candidate drugs from non-drugs, surpassing traditional methods including QED. This work highlights DrugMetric as a practical tool for drug-likeness scoring, facilitating the acceleration of virtual drug screening, and has potential applications in other biochemical fields.
CARTAR: a comprehensive web tool for identifying potential targets in chimeric antigen receptor therapies using TCGA and GTEx data
Authors: Hernandez-Gamarra Miguel , Salgado-Roo Alba , Dominguez Eduardo , Goiricelaya Seco Elena María , Veiga-Rúa Sara , Pedrera-Garbayo Lucía F , Carracedo Ángel , Allegue Catarina 
Published: July 2024

Abstract
Chimeric antigen receptor (CAR) therapy has emerged as a ground-breaking advancement in cancer treatment, harnessing the power of engineered human immune cells to target and eliminate cancer cells. The escalating interest and investment in CAR therapy in recent years emphasize its profound significance in clinical research, positioning it as a rapidly expanding frontier in the field of personalized cancer therapies. A crucial step in CAR therapy design is choosing the right target as it determines the therapy’s effectiveness, safety and specificity against cancer cells, while sparing healthy tissues. Herein, we propose a suite of tools for the identification and analysis of potential CAR targets leveraging expression data from The Cancer Genome Atlas and Genotype-Tissue Expression Project, which are implemented in CARTAR website. These tools focus on pinpointing tumor-associated antigens, ensuring target selectivity and assessing specificity to avoid off-tumor toxicities and can be used to rationally designing dual CARs. In addition, candidate target expression can be explored in cancer cell lines using the expression data for the Cancer Cell Line Encyclopedia. To our best knowledge, CARTAR is the first website dedicated to the systematic search of suitable candidate targets for CAR therapy. CARTAR is publicly accessible at https://gmxenomica.github.io/CARTAR/.
Amyloid-β-activated microglia can induce compound proteinopathies
Authors: Lee Sang Hwan , Bae Eun-Jin , Perez-Acuna Dayana , Jung Min Kyo , Han Jong Won , Mook-Jung Inhee , Lee Seung-Jae 
Published: July 2024

Abstract
Neuropathological features of Alzheimer’s disease include amyloid plaques, neurofibrillary tangles and Lewy bodies, with the former preceding the latter two. However, it is not fully understood how these compound proteinopathies are interconnected. Here, we show that transplantation of amyloid-β oligomer-activated microglia into the striatum of naïve mice was sufficient to generate all the features of Alzheimer’s disease, including widespread tauopathy and synucleinopathy, gliosis, neuroinflammation, synapse loss, neuronal death, and cognitive and motor deficits. These pathological features were eliminated by microglia depletion and anti-inflammatory drug administration.
Our results suggest the crucial roles of microglia-driven inflammation in development of mixed pathology. This study provides not only mechanistic insights into amyloid-β oligomer-triggered proteinopathies but also a novel animal model recapitulating the salient features of Alzheimer’s disease.
Inhibition of the TIM-1 and -3 signaling pathway ameliorates disease in a murine model of rheumatoid arthritis
Authors: Nozaki Yuji , Akiba Hisaya , Akazawa Hiroki , Yamazawa Hirotaka , Ishimura Kaori , Kinoshita Koji , Matsumura Itaru 
Published: July 2024

Abstract
Members of the T-cell immunoglobulin and mucin (TIM) family, which is crucial for T-cell function, are implicated in autoimmunity. TIM-1 and -3 play distinct roles in autoimmunity, with TIM-1 acting as a costimulatory molecule and TIM-3 regulating Th1 responses. We investigated the therapeutic potential of anti-TIM-1 (RMT1-10) and anti-TIM-3 (RMT3-23) antibodies in an autoimmune arthritis model. Zymosan A was used to induce arthritis in female SKG mice. The arthritis scores, histology, mRNA expression, cytokine levels, micro-computed tomography, and flow cytometry results were obtained. The application of RMT1-10 reduced the arthritis scores, histological damage, and CD4+ T-cell infiltrations, and it suppressed interleukin (IL)-6 and -17A and reduced TIM-3 mRNA expressions. RMT3-23 also lowered arthritis severity, improved histology, and reduced serum levels of tumor necrosis factor (TNF)-α and IL-17A. RMT3-23 inhibited intracellular TNF-α and IL-6 and early apoptosis. An amelioration of autoimmune arthritis was achieved by blocking the TIM-1 and -3 signaling pathways via RMT1-10 and RMT3-23 administration, leading to a widespread decrease in inflammatory cytokines. Both antibodies exhibited therapeutic effects, suggesting TIM-1 and -3 as potential targets for rheumatoid arthritis.
Jurisdiction of a State Party under Article 2(1) of the ICCPR: A Comment on A.S. and Others v. Italy
Authors: Wei Wumei 
Published: July 2024

Abstract
In A.S. and others v. Italy, the question of the jurisdiction of a State party under Article 2(1) of the ICCPR is formulated as “whether the alleged victims could be considered to have been within the power or effective control of the State party”. Per HRC’s earlier views, one form of “within the power or effective control” of a State party may be identified by the impact on the enjoyment of rights caused by a State party’s action. This can be considered as the “functional impact model”. Apparently this is what the HRC applied in this case. But a State party’s inaction cannot cause any impact unless it owes prior positive obligations towards the allegedly impacted person. As the applicable instruments allow considerable discretion to a State party to decide whether to rescue the persons in distress at sea, Italy’s “obligations” to rescue and to cooperate do not necessarily trigger Italy’s positive obligations towards the relevant persons. Taking Italy’s jurisdiction as a consequence of the causal link between the sinking of the vessel and the resulting sufferings (and deaths in some cases) of the persons on the vessel and Italy’s decisions (inaction) is the result of an expansive and improper application of the special approach adopted in other cases. To be non-arbitrary, one may find that affected persons are “within the power or effective control” of a State party: (1) where harm is caused by affirmative acts of a State party, the impact can be deemed as a manifestation that the person impacted is “within the power or effective control” of the State party; or (2) where harm is caused by an omission of a State party, there must be a prior specific legal relationship between the allegedly impacted person and the State party.
Complex management of Fabry cardiomyopathy: a case report on the use of alcohol septal ablation and chaperone therapy
Authors: Neculae Gabriela , Predescu Lucian , Popa Oana , Rusu Elena , Jurcut Ruxandra 
Published: July 2024

Abstract

Background
Cardiac involvement in Fabry disease (FD) usually manifests as a concentric left ventricular hypertrophy with rare cases developing left ventricular outflow tract obstruction (LVOTO), symptoms varying from fatigue and exercise associated dyspnoea to angina or arrhythmias.

Case summary
We present the case of a 54-year-old man with cardiovascular risk factors and aggravated exertional dyspnoea in the past year, in whom the echocardiography showed hypertrophic obstructive cardiomyopathy (HOCM). Cardiac magnetic resonance was used as differential diagnosis tool between sarcomeric HOCM and other phenocopies, suggesting a cardiac involvement of FD. Final diagnosis was formulated based on genetic testing and enzymatic activity of α-galactosidase. Left ventricular outflow tract obstruction was addressed by alcohol septal ablation successfully both in short term as well as at 1-year follow-up.

Discussion
The present case illustrates the complex clinical pathway of a patient with HOCM due to FD, where multimodality imaging was instrumental from differential diagnosis to therapeutic choices, which addressed both the pathogenic background and the organ involvement. Although at the moment the number of patients with of FD cardiomyopathy undergoing LVOTO reduction therapies is scarce, current recommendations should be extended to also include these patients.
Risk factors and prognosis of postoperative spinal cord injury in type A aortic dissection
Authors: Wei Jinhua , Hu Zhan , Wang Wei , Ding Runyu , Xu Fei 
Published: July 2024

Abstract

OBJECTIVES
To investigate the risk factors and prognosis of spinal cord injury (SCI) after surgical procedure in type A aortic dissection (AAD).

METHODS
Between January 2013 and December 2021, a total of 1647 patients with AAD underwent surgical procedure. Postoperative SCI occurred in 58 patients, including 24 patients with paraplegia and 34 patients with paraparesis. Factors associated with SCI were identified through comparison between patients with and without SCI.

RESULTS
The mean age was 48.8 ± 10.8 years for patients with SCI and 50.1 ± 12.1 years for those without SCI (P = 0.43), with a comparable gender distribution. Median numbers of intercostal and lumbar arteries with involvement were significantly higher in the SCI group (both P &lt; 0.001). The highest (P = 0.033) and lowest (P = 0.001) levels of intraoperative mean arterial pressure (MAP) were significantly lower in the SCI group. Multivariable analysis revealed the number of segmental arteries involved (odds ratio = 1.14, 95% CI 1.08–1.20, P = 0.000), and the duration of hypothermic circulatory arrest (HCA) (odds ratio  = 1.04, 95% CI 1.01–1.08, P = 0.042) was positively associated with the occurrence of SCI. Conversely, the lowest level of MAP was negatively associated with SCI (odds ratio = 0.98, 95% CI 0.96–0.99, P = 0.031). During the long-term follow-up, 14 patients with paraplegia needed a wheel chair, while only 1 patient with paraparesis needed one (P &lt; 0.001).

CONCLUSIONS
The risk of postoperative SCI increases when AAD patients experience segmental arteries involved, longer HCA duration and decreased intraoperative MAP during operation.
Cladistic species definitions can lead to under-representation of biodiversity from adaptive radiations
Authors: Turner George F 
Published: July 2024

Abstract
Many species are paraphyletic, but current taxonomic practices often do not recognize this, and attempts are made to apply a monophyletic species concept. While allowing the recognition of ecomorphologically equivalent, or even phenotypically indistinguishable allopatric, taxa as species, this often leads to combining distinctive local forms (such as cave-adapted populations) or even whole adaptive radiations (often in lakes) with widespread paraphyletic species to force species monophyly. It is suggested that this has negative consequences for our documentation and understanding of biodiversity, as well as for conservation, through issues such as lack of IUCN red-listing.