bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biodegradable HEMA‐based hydrogels with enhanced mechanical properties
Authors: Moghadam Mohamadreza Nassajian , Pioletti Dominique P. 
Published: June 2015

AbstractHydrogels are widely used in the biomedical field. Their main purposes are either to deliver biological active agents or to temporarily fill a defect until they degrade and are followed by new host tissue formation. However, for this latter application, biodegradable hydrogels are usually not capable to sustain any significant load. The development of biodegradable hydrogels presenting load‐bearing capabilities would open new possibilities to utilize this class of material in the biomedical field. In this work, an original formulation of biodegradable photo‐crosslinked hydrogels based on hydroxyethyl methacrylate (HEMA) is presented. The hydrogels consist of short‐length poly(2‐hydroxyethyl methacrylate) (PHEMA) chains in a star shape structure, obtained by introducing a tetra‐functional chain transfer agent in the backbone of the hydrogels. They are cross‐linked with a biodegradable N,O‐dimethacryloyl hydroxylamine (DMHA) molecule sensitive to hydrolytic cleavage. We characterized the degradation properties of these hydrogels submitted to mechanical loadings. We showed that the developed hydrogels undergo long‐term degradation and specially meet the two essential requirements of a biodegradable hydrogel suitable for load bearing applications: enhanced mechanical properties and low molecular weight degradation products. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1161–1169, 2016.
A phase II trial of perioperative chemotherapy involving a single intraperitoneal administration of paclitaxel followed by sequential S‐1 plus intravenous paclitaxel for serosa‐positive gastric cancer
Authors: Peng Ying‐Feng , Imano Motohiro , Itoh Tatsuki , Satoh Takao , Chiba Yasutaka , Imamoto Haruhiko , Tsubaki Masahiro , Nishida Shozo , Yasuda Takushi , Furukawa Hiroshi 
Published: June 2015

Background and ObjectivesWe carried out a phase II trial to evaluate the feasibility, efficacy, and tolerability of perioperative chemotherapy including single intraperitoneal(IP) administration of paclitaxel(PTX) followed by intravenous(IV) administrations of PTX with S‐1 in a neoadjuvant setting for serosa‐positive gastric cancer.MethodsPatients with cT4a gastric cancer were enrolled. A laparoscopic survey was performed before study inclusion for the confirmation of serosal invasion, negative lavage cytology, and negative peritoneal metastasis. IP PTX (80 mg/m2) was administered, followed by systemic chemotherapy. Surgery was performed after the completion of chemotherapy. The primary endpoint was the treatment completion rate.Results37 patients were recruited. The treatment completion rate was 67.6% (25/37; 90% CI, 52.8–80.1%), which was significantly higher than 50%; we set this as a threshold value (P = 2.4% [one‐sided]). 14 patients had target lesions; of these, 10 showed a partial response (71.4%), three had stable disease (21.4%), and one had progressive disease(7.2%). The response rate was 71.4% (10/14). All patients underwent gastrectomy with D2 lymph node dissection. The 3‐ and 5‐year OS rates were 78.0 and 74.9%, respectively.ConclusionsPerioperative chemotherapy including neoadjuvant IP PTX followed by sequential IV PTX with S‐1 for serosa‐positive gastric cancer is feasible, safe, and efficient. J. Surg. Oncol. 2015 111:1041–1046. © 2015 Wiley Periodicals, Inc.
Kirigami-based stretchable lithium-ion batteries
Authors: Song Zeming , Wang Xu , Lv Cheng , An Yonghao , Liang Mengbing , Ma Teng , He David , Zheng Ying-Jie , Huang Shi-Qing , Yu Hongyu , Jiang Hanqing 
Published: June 2015

AbstractWe have produced stretchable lithium-ion batteries (LIBs) using the concept of kirigami, i.e., a combination of folding and cutting. The designated kirigami patterns have been discovered and implemented to achieve great stretchability (over 150%) to LIBs that are produced by standardized battery manufacturing. It is shown that fracture due to cutting and folding is suppressed by plastic rolling, which provides kirigami LIBs excellent electrochemical and mechanical characteristics. The kirigami LIBs have demonstrated the capability to be integrated and power a smart watch, which may disruptively impact the field of wearable electronics by offering extra physical and functionality design spaces.
The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death
Authors: Bock Florian J. , Tanzer Maria C. , Haschka Manuel D. , Krumschnabel Gerhard , Sohm Bénédicte , Goetsch Katrin , Kofler Reinhard , Villunger Andreas 
Published: June 2015

AbstractThe tumour suppressor p53 is an important mediator of cell cycle arrest and apoptosis in response to DNA damage, acting mainly by transcriptional regulation of specific target genes. The exact details how p53 modulates this decision on a molecular basis is still incompletely understood. One mechanism of regulation is acetylation of p53 on lysine K120 by the histone-acetyltransferase Tip60, resulting in preferential transcription of proapoptotic target genes. PDCD5, a protein with reported pro-apoptotic function, has recently been identified as regulator of Tip60-dependent p53-acetylation. In an effort to clarify the role of PDCD5 upon DNA damage, we generated cell lines in which PDCD5 expression was conditionally ablated by shRNAs and investigated their response to genotoxic stress. Surprisingly, we failed to note a rate-limiting role of PDCD5 in the DNA damage response. PDCD5 was dispensable for DNA damage induced apoptosis and cell cycle arrest and we observed no significant changes in p53 target gene transcription. While we were able to confirm interaction of PDCD5 with p53, we failed to do so for Tip60. Altogether, our results suggest a role of PDCD5 in the regulation of p53 function but unrelated to cell cycle arrest or apoptosis, at least in the cell types investigated.
Social behaviour in mesopelagic jellyfish
Authors: Kaartvedt Stein , Ugland Karl I. , Klevjer Thor A. , Røstad Anders , Titelman Josefin , Solberg Ingrid 
Published: June 2015

AbstractGelatinous organisms apparently play a central role in deep pelagic ecosystems, but lack of observational methodologies has restricted information on their behaviour. We made acoustic records of diel migrating jellyfish Periphylla periphylla forming small, ephemeral groups at the upper fringe of an acoustic scattering layer consisting of krill. Groups of P. periphylla were also documented photographically using a remotely operated vehicle (ROV). Although the adaptive value of group formation remains speculative, we clearly demonstrate the ability of these jellyfishes to locate and team up with each other.
Generic, phenomenological, on-the-fly renormalized repulsion model for self-limited organization of terminal supraparticle assemblies
Authors: Nguyen Trung Dac , Schultz Benjamin A. , Kotov Nicholas A. , Glotzer Sharon C. 
Published: June 2015

Significance
Engineering nanoassemblies with uniform characteristic dimensions is of great interest given the unique properties of nanoscale building blocks and their collective response in superstructures. We present a generic, particle-based model that predicts the formation of self-limited, or “terminal,” supraparticle assemblies observed in many inorganic, colloidal, and biological systems. The key factor that leads to the self-limiting behavior is shown to be that the repulsion between particles becomes renormalized “on-the-fly” as the particles aggregate. The model explains the monodispersity of terminal assemblies formed from polydisperse nanoparticles, as observed in recent experiments. Our findings not only deepen the understanding of how self-limited, or terminal assemblies form, but also offer versatile approaches to control the dimension and shape of synthetic nanoassemblies.
Effects of Slotted Water Control Structures on Nekton Movement within Salt Marshes
Authors: Kimball Matthew E. , Rozas Lawrence P. , Boswell Kevin M. , Cowan James H. 
Published: June 2015

Abstract
Water control structures (WCSs) restrict hydrological connectivity in salt marshes and thereby impede nekton movement within the greater habitat mosaic. Transient fishery species, which spawn outside salt marshes and must get past these barriers to reach spawning areas or salt-marsh nurseries, are especially vulnerable to these structures. Water control structures incorporating slots (narrow vertical openings spanning most of the water column) are thought to improve nekton passage; however, few studies have directly examined nekton passage through WCS slots. Dual-frequency identification sonar (DIDSON) acoustic imaging was used monthly (April–September 2010) on diurnal flood tides to examine nekton movement through 15-cm-wide slots at two identical WCSs located in Louisiana tidal marsh channels. Nekton behavior was compared between these WCSs and a nearby natural salt-marsh creek. Examination of 12 h of subsampled acoustic data revealed large concentrations of salt-marsh nekton at the WCSs (n = 2,970 individuals total), but passage rates through the slots were low (≤10% of total observed individuals migrated via the slots). Most migrating fish were observed leaving the managed area and swimming against a flood tide. The mean size of migrating individuals (∼25 cm TL) did not differ in relation to swimming direction (going into versus exiting the managed marsh) and was similar to that reported from other studies examining similar slot widths. Nekton formed congregations in the WCS channel, but no congregations were observed in the natural salt-marsh creek, even though nekton species composition and sizes were similar among sites. The WCSs in our study appear to function as ecological hot spots, where large individuals may encounter enhanced foraging opportunities but also fishing mortality and where smaller individuals may experience greater predation rates.
Received July 22, 2014; accepted February 13, 2015
Single Peak Soliton and Periodic Cusp Wave of the Generalized Schrodinger–Boussinesq Equations*
Authors: Qiao Li-Jing , Tang Sheng-Qiang , Zhao Hai-Xia 
Published: June 2015

Abstract
In this paper, we study peakon, cuspon, smooth soliton and periodic cusp wave of the generalized Schrödinger–Boussinesq equations. Based on the method of dynamical systems, the generalized Schrödinger–Boussinesq equations are shown to have new the parametric representations of peakon, cuspon, smooth soliton and periodic cusp wave solutions. Under different parametric conditions, various sufficient conditions to guarantee the existence of the above solutions are given.
A New Approach to Energy Integral for Investigation of Dust—Ion Acoustic (DIA) Waves in Multi-Component Plasmas with Quantum Effects in Inertia Less Electrons
Authors: Kalita B.C. , Kalita R. 
Published: June 2015

Abstract
Dust-ion acoustic waves are investigated in this model of plasma consisting of negatively charged dusts, cold ions and inertia less quantum effected electrons with the help of a typical energy integral. In this case, a new technique is applied formulating a differential equation to establish the energy integral in case of multi-component plasmas which is not possible in general. Dust-ion acoustic (DIA) compressive and rarefactive, supersonic and subsonic solitons of various amplitudes are established. The consideration of smaller order nonlinearity in support of the newly established quantum plasma model is observed to generate small amplitude solitons at the decrease of Mach number. The growths of soliton amplitudes and potential depths are found more sensitive to the density of quantum electrons. The small density ratio r(= 1 − f) with a little quantized electrons supplemented by the dust charges Zd and the in-deterministic new quantum parameter C2 are found responsible to finally support the generation of small amplitude solitons admissible for the model.
The hidden cost of digitization – things to consider
Authors: Riley-Reid Trevar D. 
Published: June 2015

Purpose
– The paper aims to explore some of the hidden costs of these endeavors through an exploration of some the current literature. Despite the perceived ease of creating digital access, the road to digitization is long and fraught with a number of obstacles.

Design/methodology/approach
– Some of the key ideas researched are the steps to consider when planning a digitization project, the long-term sustainability of such projects and issues of copyright and ownership. This article will benefit any institution planning to embark upon a future digitization project.

Findings
– More research needs to be conducted as the needs of users change and as the technology shifts and changes.

Originality/value
– This paper will benefit any institution planning to embark upon a future digitization project.
A field-level examination of the adoption of sustainable procurement in the social housing sector
Authors: Meehan Joanne , Bryde David J 
Published: June 2015

Purpose– The purpose of this paper is to report on a field-level examination of the adoption of sustainable procurement in social housing. It explores the role of regulation and procurement consortia in sustainable procurement.Design/methodology/approach– The study employs a case study of the UK social housing sector and uses an online survey (n=116) of UK Housing Associations. Factor analysis identifies three parsimonious dimensions of sustainable procurement. Attitudinal data are analysed to explore the field-level adoption of sustainable procurement and the role of consortia.Findings– The results delineate sustainable procurement activities into three factors; direction setting, supplier-centric assurance and local socially oriented supply. High yet sup-optimal levels of sustainable procurement activity are revealed. Prevailing attitudes identify positive commitments to sustainable procurement at individual, organisational and sector levels. The value of network collaboration is identified. Tenants as critical stakeholders do not prioritise sustainable procurement creating challenge for inclusivity. Regulators are seen to a have low level of sustainable procurement knowledge and procurement consortia a high perceived knowledge.Research limitations/implications– Results provide insight into the effect of sustainable procurement policy, the role of regulators and network structures and consortia, raising issues around legitimacy, coopetition, stakeholder engagement, performance measurement, and functional/sectoral maturity.Social implications– The identification of the potential exclusion of tenants in sustainability debates is particularly significant to deliver social value.Originality/value– The relative newness of the social housing sector and its quasi-public sector status provides an original contribution to the consortia and sustainable procurement literatures.
Information infrastructure capability and organisational competitive advantage
Authors: Sook-Ling Lew , Ismail Maizatul Akmar , Yee-Yen Yuen 
Published: June 2015

Purpose
– The purpose of this paper is to propose an inclusive research model to overcome the single perspective issues of the previous research which were looking at either on knowledge management (KM) activity, information technology (IT) applications or information infrastructure capability (IIC) independently.

Design/methodology/approach
– This paper reviewed and categorised five knowledge management (KM) frameworks: first, KM foundation studies; second, resource-based view studies; third, IIC studies; fourth, competitive advantage (CA) studies; fifth, organisational information processing theory studies to propose research model. Case studies based on face-to-face interviews were conducted to empirically analyse the proposed research model.

Findings
– An inclusive research model was suggested to redress the key limitation of past studies in this research field.

Research limitations/implications
– Since Asian countries are at present heading for the creation of a knowledge economy, the present study is important to assist government and researchers to develop the most suitable information infrastructure for effective KM in the organisation. The research model proposed by the present study can also become a key reference to the governments and researchers in other developing countries towards the creation of knowledge economy.

Practical implications
– The model proposed by the present study will help organisations to examine the performance of their current information infrastructure towards developing new business processes, techniques and decisions for effective KM in the organisations.

Originality/value
– The present study is one of the pioneer studies that integrating important IICs such as the integrating capability, data management capability, security capability, utility capability and collaborating capability in the research framework to assist knowledge-based companies to enhance current KM practices and attain long-term CA.
Gender Differences in Predrinking Behavior Among Nightclubs' Patrons
Authors: Santos Mariana G. R. , Paes Angela T. , Sanudo Adriana , Andreoni Solange , Sanchez Zila M. 
Published: June 2015

BackgroundDrinking before entering nightclubs (predrinking) seems to be associated with an increase in alcohol‐related harm. This study aims to investigate gender differences in predrinking behavior and to evaluate its association with risk behaviors practiced inside nightclubs.MethodsIndividual‐level data were collected by a portal survey of 2,422 patrons at the entrance and 1,833 patrons at the exit of 31 nightclubs located at São Paulo, Brazil. The nightclubs were selected by 2‐stage sampling with probability proportional to the establishments' capacity in the first stage and a systematic sample of patrons in the entrance line in the second stage. Breath alcohol concentration (BrAC) was measured at the entrance and exit. Face‐to‐face interviews identified predrinking characteristics and risk behaviors. Weighted analyses were stratified by gender.ResultsPredrinking was practiced by 49.2% (95% confidence interval [CI] = 42.7 to 55.8) of the male patrons and 29.0% (95% CI = 20.6 to 38.9) of the female patrons (p < 0.001) on the day of the interview. When considering only predrinkers, men and women showed similar BrAC at entrance and exit and similar proportion of alcoholic intoxication (BrAC ≥ 0.38 mg/l). In both genders, people who practiced predrinking on the day of the interview were more likely to drink inside the nightclub, compared to those who did not practice predrinking (p < 0.001). Among men, the practice of predrinking increased the chance of “drinking and driving” after leaving the nightclub (odds ratio [OR] = 6.9, 95% CI = 4.1–11.5, p < 0.001). Among women, the practice of predrinking increased the chances of experiencing sexual harassment in the nightclub (OR = 2.9, 95% CI = 1.3 to 6.6, p = 0.010).ConclusionsPredrinking is more prevalent among men; however, men and women who engaged in predrinking have a similar pattern of alcohol consumption and exit BrAC. The fact that risk behaviors and illicit drug use were associated with predrinking but differ between genders suggests that a gender‐specific approach should be used in tailored interventions to prevent alcohol‐related harm in nightclubs.
The impact of paying treatment providers for outcomes: difference‐in‐differences analysis of the ‘payment by results for drugs recovery’ pilot
Authors: Mason Thomas , Sutton Matthew , Whittaker William , McSweeney Tim , Millar Tim , Donmall Michael , Jones Andrew , Pierce Matthias 
Published: June 2015

AbstractAimsTo estimate the effect on drug misuse treatment completion of a pilot scheme to pay service providers according to rates of recovery.DesignA controlled, quasi‐experimental (difference‐in‐differences) observational study using multi‐level random effects logistic regression.SettingDrug misuse treatment providers in all 149 commissioning areas in England in the financial years 2011–12 and 2012–13.ParticipantsService users treated in England in 2011–12 and 2012–13.Intervention and comparatorsLinkage of provider payments to performance indicators in eight pilot commissioning areas in England compared with all 141 non‐pilot commissioning areas in England.MeasurementsRecovery was measured by successful completion of treatment (free from drugs of dependence) and engagement with services was measured by rates of declining to continue with treatment.FindingsFollowing the introduction of the pilot scheme, service users treated in pilot areas were 1.3 percentage points [odds ratio (OR) = 0.859; 95% confidence interval (CI) = 0.788, 0.937] less likely to complete treatment compared with those treated in comparison areas. Service users treated in pilot areas were 0.9 percentage points (OR = 2.934; 95% CI = 2.094, 4.113) more likely to decline to continue with treatment compared with those treated in comparison areas.ConclusionsIn the first year of the pilot ‘Payment by Results for Drugs Recovery’ scheme in England, linking payments to outcomes reduced the probability of completing drug misuse treatment and increased the proportion service users declining to continue with treatment.
Vascular Tortuosity May Be Related to Intracranial Artery Atherosclerosis
Authors: Kim Bum Joon , Kim Seung Min , Kang Dong-Wha , Kwon Sun U. , Suh Dae C. , Kim Jong S. 
Published: June 2015

Background Conventional risk factors cannot explain the individual or ethnic difference in the location of cerebral atherosclerosis. Vascular geometry may play a role on this. Aim To investigate the association between the geometrical properties of the middle cerebral artery and intracranial atherosclerosis. Methods Stroke patients with either symptomatic middle cerebral artery or proximal internal carotid artery diseases were enrolled. The diameter, length, and tortuosity (arc-chord ratio, by percent) of the middle cerebral artery was compared between stroke patients and the age- and gender-matched healthy subjects. The geometrical property was also compared between the symptomatic middle cerebral artery and the normal-looking contralateral middle cerebral artery, and between the contralateral middle cerebral arteries in patients with symptomatic middle cerebral artery and proximal internal carotid artery diseases. Results One hundred seventy-seven patients (101 with middle cerebral artery disease and 76 with proximal internal carotid artery disease) were studied. Symptomatic middle cerebral artery was more tortuous (119·31 ± 16·95 vs. 112·98 ± 14·16; P = 0·009) than the contralateral middle cerebral artery. The contralateral middle cerebral artery of patients with symptomatic middle cerebral artery disease demonstrated a smaller proximal diameter ( P = 0·007) and a greater vascular tortuosity than the contralateral middle cerebral artery of patients with proximal internal carotid artery disease (112·01 ± 12·25 vs. 107·46 ± 9·35; P = 0·008) and corresponding middle cerebral artery of healthy control subjects (112·01 ± 12·25 vs. 108·73 ± 9·79; P = 0·04). Young age, female, small diameter, the absence of diabetes, and high tortuosity of the contralateral middle cerebral artery were independently associated with middle cerebral artery atherosclerotic disease. Conclusions High tortuosity and small diameter are related to middle cerebral artery atherosclerosis, probably by altering hemodynamics. Different degree of tortuosity may be one of the reasons for individual differences in location of cerebral atherosclerosis.
Using functional magnetic resonance imaging to explore the possible mechanism of the action of acupuncture at Dazhong (KI 4) on the functional cerebral regions of healthy volunteers
Authors: Zhang Q. , Li A. , Yue J. , Zhang F. , Sun Z. , Li X. 
Published: June 2015

AbstractAcupuncture at right Dazhong (KI 4) mostly affects functional magnetic resonance imaging signal in the right inferior frontal gyrus, right insular lobe, right thalamus, right middle frontal gyrus and right orbitofrontal cortex, which are associated with governing executive functions, emotional activities and social behaviour.