bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescent suicidal behavior across the excess weight status spectrum
Authors: Zeller Meg H. , Reiter‐Purtill Jennifer , Jenkins Todd M. , Ratcliff Megan B. 
Published: June 2013

AbstractObjective:Relative suicidal behavioral risks (ideation, attempts) for overweight, obese, and extremely obese adolescents (vs. healthy weight) and who did/did not accurately perceive themselves as overweight were examined in this study.Design and Methods:A new variable (weight status/accuracy) was computed that combined actual weight status (based on BMI) with weight perception accuracy. To evaluate the effect of weight status/accuracy on each suicidal risk behavior, logistic regression was performed to calculate odds‐ratios and 95% confidence intervals (CI). Potential model covariates included gender, age, race, survey year, and whether they had felt sad/hopeless.Results:Weight perception accuracy increased as the degree of excess weight increased. Relative to healthy weight, being obese or extremely obese (but not overweight) was associated with significantly greater risk for adolescent engagement in suicidal ideation, but was unrelated to suicide attempts. Adolescents in all excess weight categories who were accurate in their weight perception were at significantly greater odds of suicidal ideation, whereas those who were inaccurate were of no greater odds of suicidal ideation than healthy weight youth who accurately perceived their weight. Findings regarding suicide attempts varied based on actual weight/weight perception accuracy and race/ethnicity.Conclusion:The present findings are both important and clinically relevant. While widely accepted that there are multiple pathways to suicide, our understanding of adolescent suicidal behavior risks and accordingly, prevention efforts, will be informed by comprehensive prospective studies that should also, from here forward, consider categorization of the entire weight spectrum (e.g., extreme obesity).
Anti‐hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats
Authors: Bentzen Bo Hjorth , Grunnet Morten , Hyveled‐Nielsen Lars , Sundgreen Claus , Lassen Jørgen Buus , Hansen Henrik H. 
Published: June 2013

AbstractObjective:Tesofensine is a novel triple monoamine reuptake inhibitor which is in development for the treatment of obesity. Preclinical and clinical data suggest that appetite suppression is an important mechanism by which tesofensine exerts its robust weight reducing effect. Notably, the strong hypophagic response to tesofensine treatment is demonstrated to be linked to central stimulation of noradrenergic and dopaminergic neurotransmission. The sympathomimetic mode of action of tesofensine may also associate with the elevated heart rate and blood pressure observed in clinical settings, and we therefore sought experimentally to address this issue.Design and Methods:The anorexigenic and cardiovascular effects of tesofensine were studied simultaneously in telemetrized conscious rats in a combined real‐time food intake and cardiovascular telemetry monitoring system.Results:Acute administration of tesofensine caused a dose‐dependent hypophagic effect as well as increased heart rate and blood pressure. Interestingly, combined treatment with metoprolol (b1 adrenoceptor blocker, 10‐20 mg/kg, p.o.) fully prevented the cardiovascular sympathetic effects of tesofensine while leaving the robust inhibitory efficacy on food intake unaffected. Similarly, the angiotensin AT1 receptor antagonist telmisartan (1.0‐3.0 mg/kg, p.o.) did not interfere with the anti‐obesity effects of tesofensine, however, telmisartan only partially reversed the increase in systolic blood pressure and had no effect on the elevated heart rate induced by tesofensine.Conclusion:These data suggests that tesofensine causes elevations in heart rate and blood pressure by increasing sympathetic activity, and that different adrenoceptor subtypes may be responsible for the anti‐obesity and cardiovascular effects of tesofensine.
An intercomparison of subgrid models for large‐eddy simulation of katabatic flows
Authors: Smith Craig M. , Porté‐Agel Fernando 
Published: June 2013

AbstractWe present an intercomparison of three subgrid‐scale (SGS) models for large‐eddy simulation (LES) of katabatic flows. The SGS closures we study include the Smagorinsky formulation, a scale‐invariant dynamic model, and a scale‐dependent dynamic model. Downslope fluxes of mass and buoyancy deficit are highly sensitive to SGS closure choice. Due to strong shear and strong stratification, the dynamic models show a reduction of the Smagorinsky coefficient near the surface relative to the Smagorinsky model. Furthermore, results from both scale‐dependent dynamic models suggest that the assumptions of scale invariance in the dynamic model are violated. We present a second set of experiments which focus on grid resolution requirements of eddy‐resolving simulations of drainage flows. Downslope buoyancy and mass flux predictions produced by the scale‐dependent dynamic model are more robust with respect to grid resolution and grid anisotropy than the scale‐invariant dynamic and Smagorinsky SGS models. Predictions of vertically integrated downvalley mass and buoyancy fluxes are more sensitive to vertical grid resolution than horizontal grid resolution.
The Transnational Alliance for Genetic Counseling: Promoting International Communication and Collaboration
Authors: Edwards Janice G. 
Published: June 2013

AbstractThe Transnational Alliance for Genetic Counseling seeks to promote communication and collaboration among genetic counselor educators, internationally. Connecting and building global relationships among colleagues also promotes the development of the genetic counseling profession. Genetic counselors everywhere can achieve deeper understanding of their work by seeking international perspectives.
Biostratigraphic significance of brachiopods near the Devonian–Carboniferous boundary
Authors: MOTTEQUIN BERNARD , BRICE DENISE , LEGRAND-BLAIN MARIE 
Published: June 2013

AbstractThe biostratigraphic significance of selected uppermost Famennian (Upper Devonian) and lower Tournaisian (Mississippian) brachiopod genera, belonging to the orders Rhynchonellida (e.g.Araratella), Spiriferida (e.g.Sphenospira,Prospira), Spiriferinida (Syringothyris) and Productida (except Chonetidina), is discussed. Owing to the difficulties of identifying productidine and strophalosiidine genera, in contrast to rhynchonellides and spiriferides, the biostratigraphic potential of the former has generally been overlooked. Brachiopods flourished in neritic environments that were unfavourable for conodonts and ammonoids. In the absence of the latter traditional marker fossils, they are potentially important for locating the Devonian–Carboniferous boundary in shallow water depositional settings in conjunction with rugose corals and foraminifers. On a worldwide scale, further work is required to reach a better assessment of the aftermath of the Hangenberg biological Crisis on brachiopods, notably in revising the faunas from the classical areas of the Famennian and Tournaisian stages in Western Europe.
Toward Improved Spectral Measures of /s/: Results From Adolescents
Authors: Koenig Laura L. , Shadle Christine H. , Preston Jonathan L. , Mooshammer Christine R. 
Published: June 2013

PurposeThis article introduces theoretically driven acoustic measures of /s/ that reflect aerodynamic and articulatory conditions. The measures were evaluated by assessing whether they revealed expected changes over time and labiality effects, along with possible gender differences suggested by past work.MethodProductions of /s/ were extracted from various speaking tasks from typically speaking adolescents (6 boys, 6 girls). Measures were made of relative spectral energies in low- (550–3000 Hz), mid- (3000–7000 Hz), and high-frequency regions (7000–11025 Hz); the mid-frequency amplitude peak; and temporal changes in these parameters. Spectral moments were also obtained to permit comparison with existing work.ResultsSpectral balance measures in low–mid and mid–high frequency bands varied over the time course of /s/, capturing the development of sibilance at mid-fricative along with showing some effects of gender and labiality. The mid-frequency spectral peak was significantly higher in nonlabial contexts, and in girls. Temporal variation in the mid-frequency peak differentiated ±labial contexts while normalizing over gender.ConclusionsThe measures showed expected patterns, supporting their validity. Comparison of these data with studies of adults suggests some developmental patterns that call for further study. The measures may also serve to differentiate some cases of typical and misarticulated /s/.
Human interactome resource and gene set linkage analysis for the functional interpretation of biologically meaningful gene sets
Authors: Zhou Xi , Chen Pengcheng , Wei Qiang , Shen Xueling , Chen Xin 
Published: June 2013

Abstract
Motivation: A molecular interaction network can be viewed as a network in which genes with related functions are connected. Therefore, at a systems level, connections between individual genes in a molecular interaction network can be used to infer the collective functional linkages between biologically meaningful gene sets.
Results: We present the human interactome resource and the gene set linkage analysis (GSLA) tool for the functional interpretation of biologically meaningful gene sets observed in experiments. GSLA determines whether an observed gene set has significant functional linkages to established biological processes. When an observed gene set is not enriched by known biological processes, traditional enrichment-based interpretation methods cannot produce functional insights, but GSLA can still evaluate whether those genes work in concert to regulate specific biological processes, thereby suggesting the functional implications of the observed gene set. The quality of human interactome resource and the utility of GSLA are illustrated with multiple assessments.
Availability: http://www.cls.zju.edu.cn/hir/
Contact: xinchen@zju.edu.cn
Supplementary information: Supplementary data are available at Bioinformatics online.
Charge asymmetry in the proteins of the outer membrane
Authors: Slusky Joanna S. G. , Dunbrack Roland L. 
Published: June 2013

Abstract
Motivation: Outer membrane beta-barrels (OMBBs) are the proteins found in the outer membrane of bacteria, mitochondria and chloroplasts. There are thousands of beta-barrels reported in genomic databases with ∼2–3% of the genes in gram-negative bacteria encoding these proteins. These proteins have a wide variety of biological functions including active and passive transport, cell adhesion, catalysis and structural anchoring. Of the non-redundant OMBB structures in the Protein Data Bank, half have been solved during the past 5 years. This influx of information provides new opportunities for understanding the chemistry of these proteins. The distribution of charges in proteins in the outer membrane has implications for how the mechanism of outer membrane protein insertion is understood. Understanding the distribution of charges might also assist in organism selection for the heterologous expression of mitochondrial OMBBs.
Results: We find a strong asymmetry in the charge distribution of these proteins. For the outward-facing residues of the beta-barrel within regions of similar amino acid density for both membrane leaflets, the external side of the outer membrane contains almost three times the number of charged residues as the internal side of the outer membrane. Moreover, the lipid bilayer of the outer membrane is asymmetric, and the overall preference for amino acid types to be in the external leaflet of the membrane correlates roughly with the hydrophobicity of the membrane lipids. This preference is demonstrably related to the difference in lipid composition of the external and internal leaflets of the membrane.
Contact: joanna.slusky@fccc.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
The influence of product features on brand switching: the case of magnetic resonance imaging equipment
Authors: Al‐Kwifi Sam O. , McNaughton Rod B. 
Published: June 2013

PurposeThis paper seeks to provide evidence that the long‐term success of capital‐intensive technology products requires continuous integration of innovations in the form of new features and capabilities that meet broad user preferences.Design/methodology/approachMagnetic resonance imaging (MRI) research centers, which represent lead users in this industry, are used as a case study. An online survey was developed to identify and rank the main factors behind brand switching, then secondary sources are used to confirm the research results.FindingsA multi‐faceted approach to data collection is used to show that product innovations in the form of specific features are the main motive for switching to a new technology, consistent with the expectation that lead users seek technologies that maintain leading‐edge positions.Research limitations/implicationsThere are limitations to generalizing from this case study to other industries. The findings can be generalized to industries with similar characteristics, such as aircraft and heavy machinery manufacturing. In practice, managers should find a reliable strategy to assess factors underpinning brand switching that is unique to their industry. Determining the main factors behind switching is a critical matter when defining the appropriate strategy to keep their market share from eroding.Originality/valueThe literature reports considerable research that investigates brand switching. However, most of it focuses on highly competitive markets for consumer goods. This paper addresses a paucity of knowledge about what influences lead users of capital‐intensive products to switch between brands.
Portfolio district reform meets school turnaround
Authors: Marsh Julie A. , Strunk Katharine O. , Bush Susan 
Published: June 2013

PurposeDespite the popularity of school “turnaround” and “portfolio district” management as solutions to low performance, there has been limited research on these strategies. The purpose of this paper is to address this gap by exploring the strategic case of Los Angeles Unified School District's Public School Choice Initiative (PSCI) which combined both of these reforms. It examines how core mechanisms of change played out in schools and communities during the first two years of implementation.Design/methodology/approachThe paper draws on a mixed methods study, combining data from surveys, case studies, leader interviews, observations, and document review. It is guided by a conceptual framework grounded in research on school turnaround and portfolio districts, along with the district's implicit theory of change.FindingsThe paper finds early success in attracting diverse stakeholder participation, supporting plan development, and ensuring transparency. However, data also indicate difficulty establishing understanding and buy‐in, engaging parents and community, attracting sufficient supply of applicants, maintaining neutrality and the perception of fairness, and avoiding unintended consequences of competition – all of which weakened key mechanisms of change.Research limitations/implicationsData from parent focus groups and school sites may not be representative of the entire population of parents and schools, and data come from a short period of time.Practical implicationsThe paper finds that developing processes and procedures to support complex reform takes time and identifies roadblocks others may face when implementing school turnaround and portfolio management. The research suggests districts invest in ways to ensure neutrality and create a level playing field. It also indicates that leaders should anticipate challenges to engaging parents and community members, such as language and literacy barriers, and invest in the development of unbiased, high‐quality information and opportunities that include sufficient time and support to ensure understanding.Originality/valueThis paper begins to fill a gap in research on popular reform strategies for improving low‐performing schools.
New York City's Children First Networks: turning accountability on its head
Authors: Wohlstetter Priscilla , Smith Joanna , Gallagher Andrew 
Published: June 2013

PurposeThe purpose of this paper is to report findings from an exploratory study of New York's Children First Networks (CFNs); to examine what is known about the CFNs thus far, drawing on new empirical research, as well as document review and analysis of secondary sources.Design/methodology/approachOrganizational learning theory guided this qualitative study. As such, in‐depth interviews conducted with central office staff, network leadership teams, cluster leaders, and principals focused on the flow and management of information within the networks; the ways in which stakeholders developed shared meanings; how collective intelligence was built and transmitted; and organizational responses to the early experience of the CFNs.FindingsFindings highlight the tools and processes the NYC Department of Education (DOE) has put into place to operationalize the CFNs. Respondents identified as critical the replacement of supervisory leadership from the district with customization of services provided by the network teams to promote principal‐led reforms. Increased efficiency was noted by interviewees, but a number of challenges in the reform’s implementation also surfaced that point to the limitations of the CFNs as a capacity‐building mechanism.Research limitations/implicationsAs an exploratory study, this research is intended to inform larger‐scale, mixed‐methods investigations of school networks, especially those implementing reforms aimed at improving teaching and learning in schools. Research is needed into the resource exchanges between individuals and groups in networks, what differentiates high‐performing from lower‐performing networks, and how data are used to inform the evolution of network structures and practices.Originality/valueThis study is the first peer‐reviewed article on the evolution of New York City's Children First Networks.
Factors influencing consumer behaviour towards store brands: evidence from the French market
Authors: Fall Diallo Mbaye , Chandon Jean‐Louis , Cliquet Gérard , Philippe Jean 
Published: June 2013

PurposeThis paper aims to investigate how consumer and image factors as well as store familiarity influence store brand (SB) purchase behaviour. SBs are now widely offered by European mass retailers. However, consumer behaviour toward SBs is not yet clearly understood in all European markets.Design/methodology/approachThe authors analysed data collected from 266 respondents and used structural equation modelling to test the main hypotheses. They then carried out ANOVA and MANOVA analyses to test the effect of store familiarity on SB purchase behaviour.FindingsResults indicate that store image perceptions, SB price‐image, value consciousness, and SB attitude have significant and positive influence on SB purchase behaviour. Store familiarity positively influences SB choice, but not SB purchase intention. None of the socio‐demographic variables (age, gender, household income, and family size) included as control variables have an effect on SB choice.Research limitations/implicationsThe study is limited because it did not account for the effect of product categories on SB purchase behaviour. Consequently, results cannot be determined for different product categories. It would also be appropriate to measure SB choice in a more concrete way, such as using scanner data.Practical implicationsFindings highlight the importance of value consciousness, store image perceptions, and SB price‐image on SB purchase behaviour. They also show greater popularity of SB products among consumers, including those with high household income.Originality/valueThere is increased value to retailers in studying how consumer and image factors jointly influence SB purchase behaviour, whilst also accounting for store familiarity instead of brand familiarity.
Utilising product knowledge
Authors: McGuinness Donna , Hutchinson Karise 
Published: June 2013

PurposeThe purpose of this paper is to demonstrate how product knowledge is utilised by specialist independent grocery retailers (SIGRs) and how it can enhance competitive advantage for these firms.Design/methodology/approachA case study approach was deemed most appropriate to gain insight into an unexplored area of study. A total of 30 in‐depth interviews were conducted over a six‐month period supported by the collection of observation data and documentation. A purposive sampling method was adopted and the owner managers of the chosen retailers were interviewed as key informants for the study.FindingsIt was found that four main resources created the concept product strategy and ultimately explained the success of SIGRs. These relate to knowledge of how to provide a unique product; knowledge of identifying and sourcing from quality suppliers; knowledge of recipes, preparation and storage methods; and knowledge of how to merchandise products.Practical implicationsIt is argued that if these specialist grocery firms can achieve sustained competitive advantage from building and exploiting product knowledge, so too can other independent retailers in the sector.Originality/valueThis paper provides empirical evidence and theoretical understanding of product knowledge as a competitive advantage for SIGRs, which is a neglected area of study in the retail literature.
DEEP: the engagement, involvement and empowerment of people with dementia in collective influencing
Authors: Litherland Rachael , Williamson Toby 
Published: June 2013

PurposeThe purpose of this paper is to discuss the mapping processes and lessons learned in a project to scope the user involvement activity of groups of people with dementia across the UK.Design/methodology/approachData was gathered using a mapping questionnaire designed with help from people with dementia, in‐depth interviews and through a filming process at two national events. A total of 32 groups completed the main questionnaire and five groups were interviewed.FindingsThe collective voice of people with dementia is at a relatively early stage. Groups are at different stages on their journeys and many (completely understandably) prioritise peer support, and local rather than national action. But user‐led groups are growing in number and confidence. They ask for support in capacity‐building, networking and learning from each other so they can increase their influence over attitudes, policy and services.Research limitations/implicationsThe paper relies on self reports from groups the authors were able to identify.Originality/valueResearch that looks at the mechanisms that support the involvement of people with dementia is still in its infancy. This paper combines data and findings from a wide range of groups to provide recommendations about how to improve the involvement of people with dementia.