bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unilateral Third Head of Biceps Brachii with Associated Neurovascular Variants in both the Upper Limbs of a Single Cadaver
Authors: Poornima C Swathi , Bhagyalakshmi B 
Published: September 2013

During routine undergraduate dissection in the upper extremities of a 65 years old male cadaver in the department of Anatomy at Dr. PSIMS & RF, coexistence of muscular and neurovascular variants were identified .Muscular variations included presence of additional head(third) of biceps brachii in the left arm, accompanied with medially positioned median nerve in relation to brachial artery bilaterally . Teres minor muscle was not identified and the origin of long head of triceps brachii extended upto the lateral border of scapula on the left side. Both the medial cutaneous nerves of arm and forearm arouse from a single trunk bilaterally. In the right limb the axillary artery showed only four branches instead of six branches, with common trunk for thoraco-acromial and lateral thoracic artery and common trunk for subscapular and posterior circumflex humeral artery. Knowledge of coexistence of these variations would of profound importance surgically and clinically, especially in limb injuries and surgical repairs. DOI: http://dx.doi.org/10.3126/ajms.v5i1.7391 Asian Journal of Medical Science Vol.5(1) 2014 pp.81-85
DNA barcodes for species delimitation in Chironomidae (Diptera): a case study on the genusLabrundinia
Authors: Silva Fabio Laurindo da , Ekrem Torbjørn , Fonseca-Gessner Alaide Aparecida 
Published: September 2013

AbstractIn this study, we analysed the applicability of DNA barcodes for delimitation of 79 specimens of 13 species of nonbiting midges in the subfamily Tanypodinae (Diptera: Chironomidae) from São Paulo State, Brazil. Our results support DNA barcoding as an excellent tool for species identification and for solving taxonomic conflicts in genusLabrundinia.Molecular analysis of cytochrome c oxidase subunit I (COI) gene sequences yielded taxon identification trees, supporting 13 cohesive species clusters, of which three similar groups were subsequently linked to morphological variation at the larval and pupal stage. Additionally, another cluster previously described by means of morphology was linked to molecular markers. We found a distinct barcode gap, and in some species substantial interspecific pairwise divergences (up to 19.3%) were observed, which permitted identification of all analysed species. The results also indicated that barcodes can be used to associate life stages of chironomids since COI was easily amplified and sequenced from different life stages with universal barcode primers.
Active STAT5 Regulates T-bet and Eomesodermin Expression in CD8 T Cells and Imprints a T-bet–Dependent Tc1 Program with Repressed IL-6/TGF-β1 Signaling
Authors: Grange Magali , Verdeil Grégory , Arnoux Fanny , Griffon Aurélien , Spicuglia Salvatore , Maurizio Julien , Buferne Michel , Schmitt-Verhulst Anne-Marie , Auphan-Anezin Nathalie 
Published: September 2013

Abstract
In adoptive therapy, CD8 T cells expressing active STAT5 (STAT5CA) transcription factors were found to be superior to unmanipulated counterparts in long-term persistence, capacity to infiltrate autochthonous mouse melanomas, thrive in their microenvironment, and induce their regression. However, the molecular mechanisms sustaining these properties were undefined. In this study, we report that STAT5CA induced sustained expression of genes controlling tissue homing, cytolytic granule composition, type 1 CD8 cytotoxic T cell–associated effector molecules granzyme B+, IFN-γ+, TNF-α+, and CCL3+, but not IL-2, and transcription factors T-bet and eomesodermin (Eomes). Chromatin immunoprecipitation sequencing analyses identified the genes possessing regulatory regions to which STAT5 bound in long-term in vivo maintained STAT5CA-expressing CD8 T cells. This analysis identified 34% of the genes differentially expressed between STAT5CA-expressing and nonexpressing effector T cells as direct STAT5CA target genes, including those encoding T-bet, Eomes, and granzyme B. Additionally, genes encoding the IL-6R and TGFbRII subunits were stably repressed, resulting in dampened IL-17–producing CD8 T cell polarization in response to IL-6 and TGF-β1. The absence of T-bet did not affect STAT5CA-driven accumulation of the T cells in tissue or their granzyme B expression but restored IL-2 secretion and IL-6R and TGFbRII expression and signaling, as illustrated by IL-17 induction. Therefore, concerted STAT5/T-bet/Eomes regulation controls homing, long-term maintenance, recall responses, and resistance to polarization towards IL-17–producing CD8 T cells while maintaining expression of an efficient type 1 CD8 cytotoxic T cell program (granzyme B+, IFN-γ+).
A Cell-Intrinsic Requirement for NF-κB–Inducing Kinase in CD4 and CD8 T Cell Memory
Authors: Rowe Alexander M. , Murray Susan E. , Raué Hans-Peter , Koguchi Yoshinobu , Slifka Mark K. , Parker David C. 
Published: September 2013

Abstract
NF-κB–inducing kinase [(NIK), MAP3K14] is an essential kinase linking a subset of TNFR family members to the noncanonical NF-κB pathway. To assess the cell-intrinsic role of NIK in murine T cell function, we generated mixed bone marrow chimeras using bone marrow from NIK knockout (KO) and wild-type (WT) donor mice and infected the chimeras with lymphocytic choriomeningitis virus (LCMV). The chimeras possess an apparently normal immune system, including a mixture of NIK KO and WT T cells, and the virus was cleared normally. Comparison of the NIK KO and WT CD4 and CD8 T cell responses at 8 d post infection revealed modest but significant differences in the acute response. In both CD4 and CD8 compartments, relatively fewer activated (CD44hi) NIK KO T cells were present, but within the CD44hi population, a comparable percentage of the activated cells produced IFN-γ in response to ex vivo stimulation with antigenic LCMV peptides, although IL-7R expression was reduced in the NIK KO CD8 T cells. Assessment of the LCMV-specific memory at 65 d post infection revealed many more LCMV-specific WT memory T cells than NIK KO memory T cells in both the CD4 and the CD8 compartments, although the small number of surviving NIK KO memory T cells responded to secondary challenge with virus. These results demonstrate a cell-intrinsic requirement for NIK in the generation and/or maintenance of memory T cells in response to acute viral infection.
Preparation of 1,4,5‐Trisubstituted 5‐Acyl‐1,2,3‐triazoles by Selective Acylation between Copper(I)‐Carbon(sp) and Copper(I)‐Carbon(sp2) Bonds with Acyl Chlorides
Authors: Wang Bo , Liu Nan , Shao Changwei , Zhang Qun , Wang Xinyan , Hu Yuefei 
Published: September 2013

AbstractA one‐pot, three‐component method for preparation of 1,4,5‐trisubstituted 5‐acyl‐1,2,3‐triazoles has been developed based on a highly selective acylation of the copper(I)‐carbon(sp2) bond with acyl chlorides in the presence of the copper(I)‐carbon(sp) bond. The procedure is characterized by high efficiency and simple conditions.magnified image
Palladium‐Catalyzed Intramolecular ipso‐Friedel–Crafts Allylic Alkylation of Phenols via Arylative Activation of Allenes
Authors: Nemoto Tetsuhiro , Nozaki Tomoyuki , Yoshida Mariko , Hamada Yasumasa 
Published: September 2013

AbstractA novel and efficient synthetic method for functionalized spiro[4.5]cyclohexadienones was developed based on the palladium‐catalyzed sequential process: Heck insertion to an allene–intramolecular ipso‐Friedel–Crafts allylic alkylation cascade. Using 5 mol% of palladium catalyst, a wide variety of spirocycles was obtained in good to excellent yields. The developed cascade process was also applicable to the synthesis of tetrahydronaphthalene derivatives.magnified image
Copper(I) Iodide/Boron Trifluoride Etherate‐Cocatalyzed Aerobic Dehydrogenative Reactions Applied in the Synthesis of Substituted Heteroaromatic Imidazo[1,2‐a]pyridines
Authors: Cai Zhong‐Jian , Wang Shun‐Yi , Ji Shun‐Jun 
Published: September 2013

AbstractCompared with the well‐known palladium‐catalyzed oxidative dehydrogenation coupling reactions, similar transforms initiated by copper/oxygen have attracted more and more attention. We have investigated a novel construction of heteroaromatic imidazo[1,2‐a]pyridines through copper(I) iodide/boron trifluoride etherate/oxygen‐mediated dehydrogenative reactions of aryl alkyl or alkyl alkyl ketones with 2‐aminopyridines. Four hydrogen atoms are removed and two new CN bonds are formed in one step via the imine formation and oxidative C(sp3)H functionalization.magnified image
Formation of Tertiary Amides and Dihydrogen by Dehydrogenative Coupling of Primary Alcohols with Secondary Amines Catalyzed by Ruthenium Bipyridine‐Based Pincer Complexes
Authors: Srimani Dipankar , Balaraman Ekambaram , Hu Peng , Ben‐David Yehoshoa , Milstein David 
Published: September 2013

AbstractDehydrogenative coupling of primary alcohols with secondary amines to form tertiary amides and dihydrogen (H2) is efficiently catalyzed by bipyridyl‐based ruthenium pincer complexes (0.2–1 mol%) under neutral conditions (in case of the dearomatized complexes), or with added catalytic amount of base. The reaction is sensitive to steric hindrance; in the case of amidation of bulky secondary amines a less sterically hindered complex is more efficient. Selective acylation of primary amines in the presence of secondary amines was also demonstrated.magnified image
Gold‐Catalyzed Tandem Cyclization/Cycloaddition Reaction of Enynones: Highly Regioselective Synthesis of Oxabicyclic Compounds and Naphthyl Ketones
Authors: Song Xian‐Rong , Xia Xiao‐Feng , Song Bo , Tian Xiang , Zhu Hai‐Tiao , Zhou An‐Xi , Liu Xue‐Yuan , Liang Yong‐Min 
Published: September 2013

AbstractA gold‐catalyzed benzannulation of enynones for synthesizing oxabicyclic compounds and naphthyl ketones with high regioselectivity has been developed. Divergent products can be obtained from the same substrates through different types of cycloaddition. In this reaction, enynones were selectively transformed through [3+2] cycloadditions to give oxabicycles 2 in the presence of [L3AuCl] (L3=[tris(para‐trifluoromethylphenyl)phosphine], 5 mol %). When [L2(CNCH3)Au]SbF6 (L2=[2‐(di‐tert‐butylphosphino)biphenyl]) was used as the catalyst, the [4+2] cycloaddition naphthyl ketone products dihydrobenzo[f]isoquinolines 3 were obtained. The value of this method is indicated by the applicability of various enynones substrates and the highly regioselective synthesis of two potentially useful polycyclic compounds.
The risk of tuberculosis transmission to free‐ranging great apes
Authors: Wolf Tiffany M. , Sreevatsan Srinand , Travis Dominic , Mugisha Lawrence , Singer Randall S. 
Published: September 2013

AbstractPathogen exchange between humans and primates has been facilitated by anthropogenic disturbances, such as changing land use patterns, habitat destruction, and poaching, which decrease population sizes and increase levels of primate–human interaction. As a result, human and domestic animal diseases have become a recognized threat to endangered primate populations. Tuberculosis is a major global human and animal health concern, especially in equatorial Africa where many of the remaining free‐living great ape populations exist in proximity with exposed and/or infected human populations and their domestic animals. Increased anthropogenic pressure creates an opportunity for the anthropozoonotic spread of this disease. This review examines current evidence of the risk of tuberculosis transmission to great apes, the benefits and limitations of current detection methods, the impact of current great ape conservation and management strategies on this risk, and the need for an ecosystem health‐based approach to mitigating the risks of tuberculosis transmission to great apes. Am. J. Primatol. 76:2–13, 2014. © 2013 Wiley Periodicals, Inc.
Electropreparation of (±)‐10‐camphorsulfonate‐doped poly(o‐phenylenediamine) in acetonitrile and its use in determination of glucose
Authors: Zeybek Bülent , Pekmez Nuran Özçiçek , Kılıç Esma 
Published: September 2013

ABSTRACTPoly(o‐phenylenediamine) (PoPD) film has been electrochemically prepared on Pt electrode in an acetonitrile–water medium containing o‐phenylenediamine (oPD) monomer and (±)‐10‐camphorsulfonic acid (HCSA) by using the cyclic voltammetry (CV). The PoPD film (PoPD–CSA) has been characterized by FTIR, CV, EIS, FESEM, and conductivity measurement. The glucose biosensor (Pt/PoPD–CSA/GOx) has been prepared from the PoPD coated electrode by immobilizing glucose oxidase (GOx) enzyme using glutaraldehyde. The biosensor shows a low detection limit and wide linear working range, a good reusability, long‐term stability, and anti‐interference ability. The Pt/PoPD–CSA/GOx has possesses higher sensitivity (2.05 μA/mmol L−1) and affinity to glucose due to the use of CSA ion as dopant. The linear concentration ranges of Pt/PoPD–CSA/GOx have been found to be 9.6 × 10−3 to 8.2 mmol L−1 from calibration curve and 4.6 × 10−2 to 100 mmol L−1 from the relationship between the (1/glucose concentration) and (1/current difference). © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39864.
An Adaptive and Optimized Switching Observer for Sensorless Control of an Electromagnetic Valve Actuator in Camless Internal Combustion Engines
Authors: Mercorelli Paolo 
Published: September 2013

AbstractIn this paper, the design and operation of a special electromagnetic actuator as a variable engine valve actuator are presented. Further, this paper describes a feasible approximated velocity switching estimator based on measurements of current and input voltage to achieve sensorless control. The proposed concept allows a reduced‐order observer to be conceived and yields a specific control strategy with an acceptable performance. In general, this approach represents a viable strategy to build reduced‐order observers for estimating the velocity of systems through the measurement of input current and voltage. The robustness of the velocity tracking is explored using a minimum variance approach. The effect of the noise is minimized, and the position can be achieved through an adaptive and optimized structure by combining this particular velocity estimator and an observer based on the electromechanical system. Position control is achieved through an inversion of the model. This approach avoids a more complex structure for the observer and yields an acceptable performance as well as eliminating bulky position‐sensor systems. In addition, a control strategy is presented and discussed. Computer simulations of the sensorless control structure are presented in which the positive effects of the observer with optimized parameter setting are visible in the closed‐loop control.
Pharmacokinetic study of amoxicillin in human plasma by solid‐phase microextraction followed by high‐performance liquid chromatography–triple quadrupole mass spectrometry
Authors: Szultka Malgorzata , Krzeminski Rafal , Walczak Justyna , Jackowski Marek , Buszewski Boguslaw 
Published: September 2013

ABSTRACTSensitive and selective analytical procedures based on high‐performance liquid chromatography with mass spectrometric detection were developed for the determination of amoxicillin in human plasma samples. Samples were prepared by applying in‐house manufactured molecularly imprinted solid‐phase microextraction probes. The detection of target compounds was performed in multiple reaction monitoring mode. The multiple reaction monitoring detection was operated in the positive electrospray ionization mode using the transitions of m/z 366 ([M + H]+) → 349 for amoxicillin and m/z 390 ([M + H]+) → 372 for gemifloxacin. The method was validated with precision within 15% relative standard deviation and accuracy within 15% relative error. The method was successfully applied to study of the pharmacokinetics of amoxicillin in human plasma after oral administration of amoxicillin. Copyright © 2013 John Wiley & Sons, Ltd.
Silicon‐Rich Carbon Hybrid Nanofibers from Water‐Based Spinning: The Synergy Between Silicon and Carbon for Li‐ion Battery Anode Application
Authors: Kim Yong Seok , Kim Kyung Woo , Cho Daehwan , Hansen Nathaniel S. , Lee Jinwoo , Joo Yong Lak 
Published: September 2013

AbstractHybrid carbon nanofibers (NFs) with extremely high Si loading (>65 wt %) are fabricated through the water‐based electrospinning of polyvinyl alcohol/Si nanoparticle (NP) solutions for Li‐ion battery anode applications. Our Si‐rich carbon (SRC) NFs show many facilitated charge‐transport features and increased activities because of the continuous one‐dimensional (1D) carbon backbone structure with dispersed Si NP domains. This leads to superior battery performance compared to that of bare silicon NPs. The presence of carbon as 1D NFs can not only mitigate the volume change of silicon but also avoid the formation of an unstable solid‐electrolyte interface on the surface of silicon. Our study, regarding the optimum combination of C and Si in the NFs for their improved electrochemical properties and battery performance, reveals that SRC NFs containing 72.8 wt % Si (27.2 wt % C) exhibit an adequate balance between the high energy capacity of Si NPs and the dimensional stability and effective charge transport of carbon NFs. This optimum Si/C ratio leads to an outstanding cycle life, which maintains 1076 mAh g−1 capacity normalized by the total electrode mass, and a Coulombic efficiency of about 99 % over 50 cycles. Such scalable SRC NFs produced through the water‐based spinning approach can offer a cost‐effective development for high‐performance battery anodes.
Mechanistic Investigations into the Enantioselective Conia‐Ene Reaction Catalyzed by Cinchona‐Derived Amino Urea Pre‐Catalysts and CuI
Authors: Sladojevich Filippo , Fuentes de Arriba Ángel L. , Ortín Irene , Yang Ting , Ferrali Alessandro , Paton Robert S. , Dixon Darren J. 
Published: September 2013

AbstractThe enantioselective Conia‐ene cyclization of alkyne‐tethered β‐ketoesters is efficiently catalyzed by the combination of cinchona‐derived amino‐urea pre‐catalysts and copper(I) salts. The reaction scope is broad and a series of substrates can be efficiently cyclized with high yields and enantioselectivities. Herein, we present a detailed mechanistic study based on experimental considerations and quantum mechanical calculations. Several variables, such as the nature of the organic pre‐catalyst and the metal‐ion source, have been thoroughly investigated. Kinetic studies, as well as kinetic isotope effects and deuterium labeling experiments have been used to gain further insights into the mechanism and prove the cooperative nature of the catalytic system. Our studies suggest that the rate‐limiting step for the reaction involves the β‐ketoester deprotonation and that the active species responsible for the enantiodeterming step is monomeric in amino‐urea pre‐catalyst. Computational studies provide a quantitative understanding of the observed stereoinduction and identify hydrogen bonding from the urea group as a crucial factor in determining the observed enantioselectivity.
Fluorinated and Trifluoromethylated Corannulenes
Authors: Schmidt Bernd M. , Topolinski Berit , Yamada Mihoko , Higashibayashi Shuhei , Shionoya Mitsuhiko , Sakurai Hidehiro , Lentz Dieter 
Published: September 2013

AbstractThe syntheses and properties of corannulenes carrying electron‐withdrawing groups (F, CF3, C6F5) are reported. Direct fluorination of corannulene (C20H10) was carried out with xenon difluoride, and the crystal structure of the product was confirmed by the X‐ray analysis. Novel trifluoromethylated corannulenes, including the versatile 4,9‐dibromo‐1,2‐bis(trifluoromethyl)corannulene, were obtained by various established ring‐closing reactions. Besides the use of hexafluorobutyne for the construction of fluoranthenes by Diels–Alder reaction as precursor molecules to form 1,2‐disubstituted corannulenes, bis(pentafluorophenyl)acetylene was employed as dienophile. The molecular structure and crystal packing of a trifluoromethylated corannulene was determined by single‐crystal X‐ray analysis and compared with those known brominated and trifluoromethylated corannulenes. The general electron‐acceptor properties of corannulenes bearing substituents introduced in particular positions by liquid‐phase synthesis are discussed together with published computational results.
ChemInform Abstract: Effect of Ti Co‐Doping on Photoluminescence Characteristics of Eu:BaAl2O4.
Authors: Ryu H. , Bartwal K. S. 
Published: September 2013

AbstractBaAl2O4:Eu2+, Ti3+ samples are prepared by solid‐state reaction of the corresponding oxides in stoichiometric ratios with a 1 mol% fixed Eu content and Ti co‐dopant levels of 1, 2, and 3 mol% (1.
ChemInform Abstract: Sustainable Preparation of Li(FeM)PO4/C from Converter Sludge and Its Electrochemical Performance as a Cathode Material for Lithium Ion Batteries.
Authors: Zhang Zhong‐Fang , Wu Zhao‐Jin , Su Shi‐Huai , Gao Zhi‐Fang , Li Liao‐Sha , Wu Xing‐Rong 
Published: September 2013

AbstractLi(Fe,M)PO4/C (M: Mg, Al, Zn, Mn) cathode materials for lithium ion batteries are prepared by addition of H3PO4, H2O2, and NH4OH to aqueous H2SO4 solutions of converter sludge (pH 4, 45 min), followed by sintering a mixture of the obtained (Fe,M)PO4, LiOH·H2O, and polypropylene at 710 °C for 8 h.
ChemInform Abstract: Synergistic Effect of SnO2/ZnWO4 Core—Shell Nanorods with High Reversible Lithium Storage Capacity.
Authors: Xing Li‐Li , Yuan Shuang , He Bin , Zhao Ya‐Yu , Wu Xiao‐Ling , Xue Xin‐Yu 
Published: September 2013

AbstractSnO2/ZnWO4 core—shell nanorods are prepared by a two‐step method.
ChemInform Abstract: Pauson—Khand Adducts of N‐Boc‐propargylamine: A New Approach to 4,5‐Disubstituted Cyclopentenones.
Authors: Aiguabella Nuria , Pesquer Albert , Verdaguer Xavier , Riera Antoni 
Published: September 2013

AbstractThis protocol is based on the Pauson—Khand reaction of alkynes and norbornadiene yielding masked cyclopentadienones with a readily functionalizable double bond.
ChemInform Abstract: A Convenient Method for the Synthesis of Allenoates from 4‐Hydroxyalk‐2‐ynoates with PPh3.
Authors: Kim Hyuna , Jin Kyung Yong , Ha Tae Hee , Yu Chan‐Mo 
Published: September 2013

AbstractThis practical and convenient method to synthesize allenoates is only applicable to acyclic substrates.
ChemInform Abstract: BINAM‐mono‐PHOS as New Entry for Multinuclear Copper Catalysts in Asymmetric Conjugate Addition of Organozinc Reagents.
Authors: Endo Kohei , Takayama Ryotaro , Shibata Takanori 
Published: September 2013

AbstractAmong a large variety of binaphthyl compounds evaluated as chiral ligands, high yields and enantioselectivities are achieved with (Ia) for the addition of ZnEt2.
ChemInform Abstract: Simple and Efficient Procedure for Synthesis of N′‐Arylamidines Using Trimethylaluminum.
Authors: Korbad Balaji L. , Lee Sang‐Hyeup 
Published: September 2013

AbstractA simple and efficient method for the synthesis of N′‐arylamides (III) from various aliphatic and aromatic nitriles and a variety of aromatic amines under mild conditions is presented.
ChemInform Abstract: A Highly Efficient Protocol for the Regio‐ and Stereoselective Synthesis of Spiro Pyrrolidine and Pyrrolizidine Derivatives by Multicomponent Reaction.
Authors: Dandia Anshu , Jain Anuj K. , Laxkar Ashok K. , Bhati Dharmendra S. 
Published: September 2013

AbstractAzomethine ylides, generated in situ from ketones (I) and (VIII) and amino acids, undergo 1,3‐dipolar cycloaddition with alkenes to form a broad spectrum of the pharmaceutically important heterocyclic scaffolds.
ChemInform Abstract: Synthesis and Cycloaddition Chemistry of Oxetanyl‐Substituted Sydnones.
Authors: Nassoy Anne‐Chloe , Raubo Piotr , Harrity Joseph P. A. 
Published: September 2013

AbstractTitle compounds (III) are prepared by magnesiation of 4‐unsubstituted sydnones followed by reaction with oxetan‐3‐one.