bluuebunny/crossref_metadata_2025_split huggingface dataset:
1396 – Implementation Of The Integrated Plan Of Suicidal Behavior Prevention In The Republic Of Belarus For 2009–2012: The Main Results Ahieved
Authors: Igumnov S.A. 
Published: July 2013

ObjectivesThe Integrated plan (IP) is an interdepartmental document in the implementation of which 25 relevant Ministries, departments, executive authorities and public organizations are involved. The coordinator and responsible executor is the Ministry of Health.AimOf the IP to reduce the level of suicides among the population of the Republic of Belarus.MethodsThe main efforts are focused on the following areas: developing of normative documents regulating the rendering of aid to people in crisis situations; teaching the workers of educational, health and social institutions to identify depressions and suicidal signs at an early stage; implementation of multidisciplinary approach in rendering aid to patients in the crisis conditions; spreading information about the activity of suicide prevention services.ResultsAs a result of implementation of the activities of the IP, already in 2010 it was observed that the overall number of suicides committed in Belarus reduced for 9.6% in comparison to 2009. In 2011 the rate of suicides reduced in comparison to 2010: in general population - for 12.3%, from 2478 to 2170 cases, with the relative rate lowering from 26.1 to 22.9 cases per 100.000 of population. The rates are minimal in the last 15 years.ConclusionsThe implementation of the Integrated Plan of suicidal behavior prevention in 2009-2011 allowed to stabilize the suicide situation and to reduce the rates of suicidal activity of the population.
1397 – Extreme Polypharmacy In a Patient With Schizophrenia
Authors: Agarwal S. , Agarwal N.K. 
Published: July 2013

IntroductionPolypharmacy, involving anti-psychotic drugs as well as drugs for co-morbid conditions is common. We report a patient on 31 different medications involving taking at least 40 pills a day.ObjectivesTo highlight the problem with excessive polypharmacy.AimsTo report a case of extreme polypharmacy.MethodsThe medical and medication chart of one patient was reviewed due to extreme polypharmacy.ResultsThe female patient aged 67 was on the following 32 medications: Fexofenadine 180 mg, Amlodipine 5 mg, Asprin 81 mg, Bupropion-XL 150 mg, Citalopram 10 mg, Citalopram 20 mg, Clobetasol 0.05% cream, Clonazepam 1 mg, Rosuvastatin 10 mg, Divalproex-ER 500 mg, Ferrous Sulphate 325 mg, Furosemide 20 mg, HC Valerate 0.2% cream, Ibandronate Sod 150 mg, Lamotrigine 100 mg, Levothyroxine 50 mcg, Losartan Pot 100 mg, Meloxicam 7.5 mg, Metoclopram 10 mg, Oxycod/Apap 5-325, Plavix 75 mg, Polyeth Glyc 3350 NF Powder, Pot. Cl Micro 20 Meq, Promethazine DM, Omeprazole 20 mg, Os Cal 500 plus D, Quetiapine Fum 200 mg, Quetiapine 300 mg, Multivitamin Stovite One,Trazodone 100 mg, and Vitamin D 400 units. Overall, the patient was taking 38 - 41 pills per day, oral liquid medication 2-5 per day and applying two lotions for a total of 4 times per day.ConclusionThis case illustrates extreme polypharmacy. Although all medications may be clinically warranted, co-morbid conditions and seeing different specialists can result in runaway polypharmacy. Non-compliance, drug-drug interactions and serious side effects can result from extreme polypharmacy. The cure can potentially become a disease.
1403 – Hyperprolactinemia And Antipsychotic Use In Psychiatric Patients
Authors: Carvalho M. , Góis C. 
Published: July 2013

Hyperprolactinemia is a common, but neglected, adverse effect of conventional and some atypical antipshycotics, such as risperidone, paliperidone, amisulpride and zotepine, usually known as “prolactin-raising” antipshycotics. It occurs in almost 42% of men and in 75% of women with schizophrenia taking risperidone and involves prolactin levels greater than 210-420 mUI/L and 210-520 mUI/L, respectively. Atypical antipsychotics such as clozapine, quetiapine, olanzapine, aripiprazole and ziprazidone have a minimal or no significant effect in prolactin levels, being known as “prolactin-sparing” antipsychotics.This work aims to review the recent literature data concerning the management of the antipsychotic taking patients with hyperprolactinemia, regarding the clinical evaluation, differential diagnosis, therapeutic strategies and international recommendations.With the exception of the “Maudsley Prescribing Guidelines” and the “National Collaborating Centre for Mental Health”, none of the current international psychiatric guidelines recommend a routine baseline prolactin determination, neither periodic prolactin levels without the presence of any hyperprolactinemia symptoms. These symptoms include gynaecomastia, galactorrhoea, menstrual irregularities, infertility, sexual dysfunction, acne and hirsutism.Antipsychotic treatment is the most common cause of hyperprolactinemia in psychiatric patients, although it may also occur during the use of tricyclic and tetracyclic antidepressants, selective serotonin reuptake inhibitors and monoaminoxidase inhibitors, and in the presence of hyphotalamic and pituitary neoplasic disease.Antipsychotic-induced hyperprolactinemia therapeutic strategies may include antipsychotic dosage reduction, switching to a “prolactin-sparing” antipsychotic or using a dopamine receptor agonist (bromocriptine, cabergoline or amantadine). Given the osteopenic/ osteoporosis risk, combined oral contraceptives must be considered in women in fertile age with amenorrhoea for a year.
1407 – Psychiatric Reform In Crete And Increasing Trend Of Involuntary Admissions
Authors: Stefanakis Z. , Basta M. , Sfakiotaki M. , Koutentaki E. , Koudas V. , Vgontzas A.N. 
Published: July 2013

IntroductionDeinstitutionalization in Crete, as part of the psychiatric reform, resulted in the closure of the only psychiatric hospital of the island in 2006.ObjectivesTo explore the trends of yearly involuntary admissions in the Psychiatric Department of the University Hospital of Crete (PD/UHC) (2008-2011), the only inpatient public unit to receive involuntary admissions in a region of 400,000 residents, and the profile of the patients admitted.AimsTo find possible associations between the closure of the Psychiatric Hospital in Crete and the number of involuntary admissions.MethodsWe examined the records of total and involuntary admissions in PD/UHC between 2008–2011. In a subset of 400 inpatients admitted between Nov/2011 and Aug/2012, sociodemographic/psychopathology parameters were also examined. Statistical analysis was conducted with chi-square and regression analysis models.ResultsYearly involuntary admissions have increased by 245% during a period of 4 years, with the number of total admissions having increased by 22%. Within the subset of patients admitted during the last year, involuntary admissions account for the 47% of total admissions. Mean age of patients was 41.3 ± 1.38 years. Chi-square tests showed that male gender, aggression and positive psychotic symptoms at admission, absence of spouse/children are associated with involuntary admissions. Multivariate analysis revealed significant correlations for male gender and aggression.ConclusionDeinstitutionalization, i.e. closure of the only psychiatric hospital in Crete, has resulted in a significant and marked increase of involuntary admissions, a fact that also reflects the lack of community services and infrastructure.
1414 – Interruption Of Anti Psychotic Treatment Of First Episode Psychosis Associated With a Five-fold Increased Risk Of Relapse
Authors: Elanjithara T. , Winton-Brown T. , McGuire P. 
Published: July 2013

IntroductionDiscontinuation of antipsychotic medication occurs in 40-55% of patients following first episode psychosis. It is only recently that the impacts of short periods of nonadherence in first episode psychosis are being understood.AimTo study the impact of short periods of interruptions in antipsychotic treatment in first episode psychosis.Method127 consecutive cases of first episode non-affective psychosis (F20-29 ICD-10) presenting to a specialist first episode psychosis service in South East London. Patients were interviewed at baseline by a researcher using the PANSS and other symptom scales at the start and at 18 months. Clinical notes were analysed using operational criteria set for recovery, exacerbation and relapse. Medication utilisation assessed using patient report and clinical notes to identify interruptions of ≥ 1 month in treatment.Results58% (n = 73) patients had a treatment break due to non-adherence in the follow up period. 18 patients had treatment break before first recovery and their time to recovery was significantly prolonged than those without a break (mean 210 days Vs 127 days, t = 2.9, P = 0.01). The odds of relapse was 5.4 for those with treatment break (≥ 1 month) compared to those without break (p = 0.0001, CI 2.1–11). About 40% relapses occurred in first month of treatment break and mean time to relapse was 3 months.ConclusionAntipsychotic treatment should be uninterrupted in the early stages of psychosis and periods of even short breaks in treatment carries risk of adverse outcome like longer time to recover and high risk of immediate relapse.
1418 – How Do The Genetic And Environmental Factor Influence The Mental Health Of Chongqing Twins Children
Authors: Fu Y. , Hou X. , Jia L. , Qin Q. , Meng H. , Li T. 
Published: July 2013

ObjectivesTo estimate the heritability of mental health of children by using a twin design method of quantitative genetic analysis. To analysis the influences of family environment on children mental health.MethodsUsing cross-sectional design twins aged 6–16 years were recruited. Using SDQ(Strengths and Difficulties Questionnaire)which was examined by parents (>=11)to evaluate the children mental health. The general questionnaire, FADGFS (General Functioning Scale of the MacMaster Family Activity Device), SLE (stressful life events), FSQ (Family Stresses Questionnaire), FLQ (Family Life Questionnaire), EFQ (Everyday Feelings Questionnaire) were used to collect information about family environment from parents. Zygosity was determined by the DNA picked up from cheek mucosa of twins children. Holzinger analysis was employed to estimate the heritability of mental health.Results122 pairs of twins (103 pairs DNA were picked up successfully, including 54 MZ and 49 DZ twin pairs.Heritability of mental health: emot (emotion): 0.86, hyper (hyperactivity): 0.75, total: 0.61, cond (conduct): 0.4, proso (prosocial): 0.12, peer (peer): −0.97. In twins family the score of FAD-GFS was significantly correlated with proso (r = −0.200), the score of FSQ, EFQ was significantly correlated with total (r = 0.206, −0.304), FLQ(include three factor) was significantly correlated with total, proso (r = − 0.472, 0.389; r = −0.277,.247; r = −0.298,0.364), the score of father authoritative parenting style was significantly correlated with total, proso r = −0.244,0.207 the score of mather authoritative parenting style was significantly correlated with total, proso r = −0.437, 0.342. The score of family cohesion was significantly correlated with total proso (r = −0.315,0.432), the score of family adaptability was significantly correlated with total, proso r = −0.359, 0.357.ConclusionEmotional problems were influenced by genetic factors most followed by inattention-hyperactivity problems and total difficulties environment factors play a main role in conduct problems and prosocial degree while peer problems were only influenced by environment factors. Each aspect of family environment influence children mental health differently.
1419 – Language Changes As An Important Psychopathological Phenomenon Of Mild Depression
Authors: Smirnova D. , Sloeva E. , Kuvshinova N. , Krasnov A. , Romanov D. , Nosachev G. 
Published: July 2013

ObjectiveDifficulties in diagnostics of mild depressions are related to clinical interpretation of thought structure and content within depressive triad. Whereas nonverbal (motor) and affective components are similar to variations of normal sadness in healthy individuals, associative component reveals the most sensitive psychopathological finding being represented in definite language changes.Methods124 patients and 77 healthy controls, including 35 with normal sadness reactions, were observed. Speech (superficial, deep levels, Russian language) was studied using standardized psycholinguistic procedures. Statistical data evaluation included descriptive methodics, nonparametric analysis, mathematic modeling (discriminate analysis).ResultsThree clinical groups were formed upon to psychopathological subtypes (anxious, asthenic-hypodynamic, melancholic mild depressions). Leading hypotymic affect correlated with content of affective component, semantics of associative component, pronounced component of depressive triad and direction of the prevailing time representation.Lexical-stylistic sublevel of speech demonstrated verbosity, narration dominated over reasoning, signs of oral speech, increased number of phraseologisms, tautologies, lexical and semantic repetitions, metaphors, comparisons, inversions, ellipsis. Lexical-grammer sublevel contained more pronouns of all types with the prevalence of personal pronouns, imperfective verbs in preferential past tense. Syntax-stylistic sublevel represented the prevalence of simple sentences (truncated, impersonal), inversive word order. Component analysis of speech demonstrated the qualitative distortion and reduction of semantic component.Disruptions in structure and semantics of speech related to the most clinically pronounced thought disorder were presented in melancholic depression. Superficial level of speech was damaged mostly in asthenic-hypodynamic depression. Speech was similar to healthy controls and demonstrated the highest among subgroups cognitive adaptability level in anxious subtype.
1421 – Outpatient Depression Treatment - Comparative Analysis Of General Practitioner's, Psychiatrist's And Psychotherapist's Treatment Strategies
Authors: Bermejo I. , Kristion L. , Härter M. 
Published: July 2013

ObjectiveTo analyze the status quo of outpatient treatment of depression from general practitioner's, psychiatrist's and psychotherapist's point of view.MethodPooled analysis of the outpatient treatment of depression of general practitioners (n = 180), psychiatrists (n = 71), and psychotherapists (n = 160). Survey performed to uncover the clinical process the clinical process, the perceived obstacles, and subjective responsibilities.ResultsThe diagnosis of all three groups was based primarily on their clinical impression, rather than on formal diagnosis criteria. The cooperation with the medical-psychotherapeutic sector was assessed more favorably than cooperation with the psycho-social sector.ConclusionsNeeds for improvements particularly regarding diagnoses and an interdisciplinary cooperation.
1428 – Predictors Of Multidimensional Fatigue In General Population In Greece
Authors: Lyrakos G.N. , Spyropoulos I. , Xatziagelaki E. , Tinas C. , Kostopanagiotou G. , Spinaris V. 
Published: July 2013

IntroductionFatigue is of great clinical and investigational importance. It is a prevalent symptom in the general population and it is a central symptom in many diseases, while fatigue is considered a normal occurrence in daily life, it is also a symptom associated with a variety of physiological and psychological conditions.ObjectivesTo compare levels of the various aspects of fatigue with sociodemografic characteristics in order to build a model explaining fatigue in general population.AimsTo see if negative emotions are significant predictors of fatigue.MethodsWe conducted a survey in a random sample of 712 healthy adults (534 women and 169 men), using the Multidimensional Fatigue Inventory (MFI-20). Statistical analysis was conducted with SPSS 16 for windows. Multivariate linear regression analyses were performed to look for independent associations between the five domains of the MFI and the variables of interest.ResultsIn general fatigue, stress (b = .217 p < .05) and satisfaction with life (b = -.143 p < .05) along with sex, education and PCS12 explained 47% of the variance. In reduced motivation stress (b = .246 p < .05) and depression (b = .266 p < .05) explained 34% of the variance. In mental fatigue, reduced activity and physical fatigue, only sociodemografic characteristics and health related quality of life had significant effect in the models.ConclusionsA small part of fatigue in general population is explained from negative emotions, but a larger amount of the variance is explained by sex, education and age. Also limitations in day activities pay a significant role in the model of fatigue.
1430 – Dementia And Lower Blood Pressure In Seven Low And Middle Income Countries: The 10/66 Cross-sectional Surveys
Authors: Stewart R. , Lombardo F.L. , Albanese E. 
Published: July 2013

IntroductionA relative decline in systolic blood pressure has been found to occur prior to and around the clinical onset of dementia but the reasons for this remain unclear.Aims and objectivesIn a large series of surveys carried out using identical methodology in populations with relatively low mean blood pressures we investigated the consistency of the association between dementia, dementia severity and resting blood pressure.MethodsThe analysed sample comprised 15,022 participants from eleven cross-sectional surveys carried out in seven low and middle income countries (Cuba, Dominican Republic, Peru, Venezuela, Mexico, China and India). Associations between dementia status (ascertained through a detailed assessment with extensive cross-cultural validation) and resting blood pressure were described for each sample and then compared in meta-analyses.ResultsIn age- and sex-adjusted linear regression analyses, there was a high level of between-site heterogeneity in these associations (I-squared 60.2% for dementia and SBP). The only site with significant and consistent associations was Cuba (n=2944), the sample with highest mean systolic blood pressure, where dementia was associated with 7.9mmHg lower systolic blood pressure (95% CI 4.7-11.1) and 2.6mmHg lower diastolic blood pressure (95% CI 0.9-4.2). In general, associations between dementia and lower blood pressure were weak or absent in these surveys.ConclusionsThe association between dementia and low blood pressure, generally observed in Western settings was not observed in these populations with lower hypertension prevalence. These findings do not support a hypothesis that lower blood pressure in dementia is purely secondary to underlying neurodegeneration.
1432 – Single-prolonged Stress Induced Endoplasmic Reticulum - Dependent Apoptosis In The Hippocampus In The Rat Model Of Post-traumatic Stress Disorder
Authors: Han F. , Shi Y. 
Published: July 2013

BackgroundPost-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience. Some studies showed low hippocampal volumes in PTSD patients. Our previous research indicated apoptosis induced such atrophy in the hippocampus. Endoplasmic reticulum stress -induced apoptosis has been implicated in the development of disorder diseases.AimOur study was to reveal whether apoptosis induced by single-prolonged stress (SPS) in the hippocampus involved in Endoplasmic reticulum-related pathway through observation expression of three important apoptosis-related indicators on ER pathway: Glucose-regulated protein (GRP) 78; calcium/calmodulin/CaM kinaseIIα and caspase-12.MethodsWistar rats were killed at 1, 4 and 7 days after exposure to SPS. The apoptotic cells in the hippocampus were assessed by TUNEL method and the free intra¬cellular Ca2+ concentration was measured. Immunohistochemistry, western blotting and RT-PCR were used to detection expression of GRP78, Ca2+/Calmodulin/ CaM kinase IIα and caspase-12.ResultsOur results showed that apoptosis exactly occurred in hippocampus of SPS rats. Both GRP78 and Caspase-12 were significantly up-regulated during early PTSD. They reached peak in the 4 days and then returned to normal levels in 7 days after SPS. The free intra¬cellular Ca2+ concentration was significantly higher in 1 day after SPS and decreased in 7 days; However, CaM expression significantly increased, while CaMKIIα expression significantly decreased in the hippocampus 1 day after SPS.ConclusionSPS induced the change of GRP78, Ca2+ and caspase-12 in the hippocampus of PTSD rat, indicating that the endoplasmic reticulum pathway was involved in the process of SPS-induced apoptosis.
1433 – Study On The Influence Of Genetic And Environmental Factor On Personality Of Chongqing Twins Children
Authors: Fu Y. , Hou X. , Qin Q. , Jia L. , Meng H. , Li T. 
Published: July 2013

ObjectiveTo estimate the heritability of personality of children by using a twin design method of quantitative genetic analysis. To analysis the influences of family environment on children personality.MethodsEPQ(Eysenck Personality questionnaire) applying on twins children aged 6-16years to evaluate the children personality.The general questionnaire, PSDQ Parenting Style and Dimension Questionnaire, FAD-GFS(The General Functioning Scale of the MacMaster Family Activity Device), SLE(stressful life events), FSQ(Family Stresses Questionnaire), FLQ(Family Life Questionnaire), EFQ(Everyday Feelings) were used to collect information about family environment from parents. Zygosity was determined by the DNA picked up from cheek mucosa of twins children. Holzinger analysis was employed to estimate the heritability of mental health.Results122 pairs(244 children) of twins (103 twin pairs DNA were picked up successfully), including 54 MZ twin pairs and 49 DZ twin pairs.The heritability of personality:N(Extrovision-Introvision):0.71,P(Psychoticism):0.56,L(Lie):0.43,E(Neuroticism):0.07.In twins family educated-year of father was significantly correlated with EPQ-E,EPQ-N(r = 0.167,0.145);educated-year of mather was significantly correlated with EPQ-N(r = -0.145);the score of FAD-GFS was significantly correlated with EPQ-E(r = - 0.235);FLQ was significantly correlated with EPQ-n(r = 0.356);the score of father authoritative parenting style was significantly correlated with EPQ-p r = -0.196 ;the score of mather authoritative parenting style was significantly correlated with EPQ-e r = 0.230. the score of family cohesion was significantly correlated with EPQ-n(r = 0.198).ConclusionEmotional problems were influenced by genetic factors most followed by inattention-hyperactivity problems and total difficulties environment factors play a main role in conduct problems and prosocial degree while peer problems were only influenced by environment factors. Each aspect of family environment, influence children personality and mental differently.