bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighborhood Socioeconomic Disadvantage Across the Life Course and Premature Mortality
Authors: Lawrence Wayne R. , Kucharska-Newton Anna M. , Magnani Jared W. , Brewer LaPrincess C. , Shiels Meredith S. , George Kristen M. , Lutsey Pamela L. , Jenkins Brittany D. , Sullivan Kevin J. , Carson April P. , Freedman Neal D. 
Published: August 2024

ImportanceThere are consistent data demonstrating that socioeconomic disadvantage is associated with risk of premature mortality, but research on the relationship between neighborhood socioeconomic factors and premature mortality is limited. Most studies evaluating the association between neighborhood socioeconomic status (SES) and mortality have used a single assessment of SES during middle to older adulthood, thereby not considering the contribution of early life neighborhood SES.ObjectiveTo investigate the association of life course neighborhood SES and premature mortality.Design, Setting, and ParticipantsThis cohort study included Black and White participants of the multicenter Atherosclerosis Risk in Communities Study, a multicenter study conducted in 4 US communities: Washington County, Maryland; Forsyth County, North Carolina; Jackson, Mississippi; and the northwestern suburbs of Minneapolis, Minnesota. Participants were followed up for a mean (SD) of 18.8 (5.7) years (1996-2020). Statistical analysis was performed from March 2023 through May 2024.ExposureParticipants’ residential addresses during childhood, young adulthood, and middle adulthood were linked with US Census–based socioeconomic indicators to create summary neighborhood SES scores for each of these life epochs. Neighborhood SES scores were categorized into distribution-based tertiles.Main Outcomes and MeasuresPremature death was defined as all-cause mortality occurring before age 75 years. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs.ResultsAmong 12 610 study participants, the mean (SD) age at baseline was 62.6 (5.6) years; 3181 (25.2%) were Black and 9429 (74.8%) were White; and 7222 (57.3%) were women. The lowest, compared with the highest tertile, of neighborhood SES score in middle adulthood was associated with higher risk of premature mortality (HR, 1.28; 95% CI, 1.07-1.54). Similar associations were observed for neighborhood SES in young adulthood among women (HR, 1.25; 95% CI, 1.00-1.56) and neighborhood SES in childhood among White participants (HR, 1.25; 95% CI, 1.01-1.56). Participants whose neighborhood SES remained low from young to middle adulthood had an increased premature mortality risk compared with those whose neighborhood SES remained high (HR, 1.25; 95% CI, 1.05-1.49).Conclusions and RelevanceIn this study, low neighborhood SES was associated with premature mortality. The risk of premature mortality was greatest among individuals experiencing persistently low neighborhood SES from young to middle adulthood. Place-based interventions that target neighborhood social determinants of health should be designed from a life course perspective that accounts for early-life socioeconomic inequality.
Primary Care Use and 90-Day Mortality Among Older Adults Undergoing Cancer Surgery
Authors: Kazaure Hadiza S. , Neely N. Ben , Howard Lauren E. , Hyslop Terry , Shahsahebi Mohammad , Zullig Leah L. , Oeffinger Kevin C. 
Published: August 2024

ImportanceMultimorbidity and postoperative clinical decompensation are common among older surgical patients with cancer, highlighting the importance of primary care to optimize survival. Little is known about the association between primary care use and survivorship among older adults (aged ≥65 years) undergoing cancer surgery.ObjectiveTo examine primary care use among older surgical patients with cancer and its association with mortality.Design, Setting, and ParticipantsIn this retrospective cohort study, data were abstracted from the electronic health record of a single health care system for older adults undergoing cancer surgery between January 1, 2017, and December 31, 2019. There were 3 tiers of stratification: (1) patients who had a primary care practitioner (PCP) (physician, nurse practitioner, or physician assistant) vs no PCP, (2) those who had a PCP and underwent surgery in the same health system (unfragmented care) vs not (fragmented care), and (3) those who had a primary care visit within 90 postoperative days vs not. Data were analyzed between August 2023 and January 2024.ExposurePrimary care use after surgery for colorectal, head and neck, prostate, ovarian, pancreatic, breast, liver, renal cell, non–small cell lung, endometrial, gastric, or esophageal cancer.Main Outcomes and MeasuresPostoperative 90-day mortality was analyzed using inverse propensity weighted Kaplan-Meier curves, with log-rank tests adjusted for propensity scores.ResultsThe study included 2566 older adults (mean [SEM] age, 72.9 [0.1] years; 1321 men [51.5%]). Although 2404 patients (93.7%) had health insurance coverage, 743 (28.9%) had no PCP at the time of surgery. Compared with the PCP group, the no-PCP group had a higher 90-day postoperative mortality rate (2.0% vs 3.6%, respectively; adjusted P = .03). For the 823 patients with unfragmented care, 400 (48.6%) had a primary care visit within 90 postoperative days (median time to visit, 34 days; IQR, 20-57 days). Patients who had a postoperative primary care visit were more likely to be older, have a higher comorbidity burden, have an emergency department visit, and be readmitted. However, they had a significantly lower 90-day postoperative mortality rate than those who did not have a primary care visit (0.3% vs 3.3%, respectively; adjusted P = .001).Conclusions and RelevanceThese findings suggest that follow-up with primary care within 90 days after cancer surgery is associated with improved survivorship among older adults.
Spatiotemporal fault estimation for switched nonlinear reaction–diffusion systems via adaptive iterative learning
Authors: Peng Zenglong , Song Xiaona , Song Shuai , Stojanovic Vladimir 
Published: August 2024

SummaryIn this paper, an iterative learning‐based spatiotemporal fault estimation issue in switched reaction–diffusion systems is investigated. Initially, average dwell‐time switching rules are utilized to describe a class of switched reaction–diffusion systems characterized by mode jumps. Then, different from the existing fault estimation methods, a fault estimator is designed for spatiotemporal faults to realize an accurate estimation of faults by using the iterative learning strategy. Subsequently, to improve the speed of fault estimation, an adaptive iterative learning‐based fault estimation law is proposed, which can achieve faster fault estimation by continuously adjusting the iterative learning gain. Moreover, sufficient conditions for the convergence of the fault estimation error are obtained by using the ‐norm and the mathematical induction methods. Finally, an illustrative example is presented to check the practicality and superiority of the proposed fault estimation scheme.
The PolyCraft Polymer–Metal Hybrid Smart Stent System: The Future of Cardiovascular Blood Pressure Management
Authors: Wang Lei , Oyunbaatar Nomin‐Erdene , Jeong Yun‐Jin , Lee Heonzoo , Won Yonggwan , Jeong In‐Seok , Kayumov Mukhammad , Obiweluozor Francis O. , Kim Dong‐Su , Lee Dong‐Weon 
Published: August 2024

AbstractTo address the complication of in‐stent restenosis that occurs with traditional stent treatments, this study proposes an innovative hybrid smart stent‐based medical system. This approach allows to overcome the limitations of existing bare metal or polymer‐based smart stents, which interfere with radio frequency signals, less deformability, or do not provide adequate radial support, respectively. The proposed hybrid stent, which uses a Co/Cr–polycaprolactone (PCL)–Co/Cr configuration connected by a unique dual inverted Y‐type connector for metal–polymer integration is integrated with a LC wireless pressure sensor fabricated through a semiconductor process. The fabricated hybrid stent made by laser machining and custom‐made 3D printing, offers excellent properties such as radial strength (0.125 N/mm) and flexibility (2 N mm2) and provides intravascular information to the outside through the integrated sensor without signal degradation. After basic experiments using a phantom, animal experiments are conducted by combining the fabricated sensor with artificial blood vessel, and the results measured by the external antenna system are consistent with the results of a commercial reference sensor. The proposed wireless sensor‐based smart stents and artificial blood vessels aim to gather diverse patient health data for integration with artificial intelligence, laying the groundwork for next‐generation medical innovation.
A Ubiquitin‐Competitive Strategy Based on the Element Microenvironment to Treat Osteoarthritis
Authors: Kong Keyu , Yang Yuqi , Chang Yongyun , Chen Youdong , Yang Xiao , Qin Jiahao , Song Zhuorun , Lu Shunyi , Zhai Zanjing , Ge Jun , Li Huiwu , Cheng Liang 
Published: August 2024

AbstractRecent research on ferroptosis and cuproptosis has underscored the crucial role of trace element regulation in osteoarthritis (OA) treatment. However, research systematically addressing the alterations in nutrient elements in OA cartilage is lacking. This study is initiated using clinical specimens to quantify metal element concentrations in both damaged and intact cartilage to identify deficient trace elements within the inflammatory and senescent microenvironments of OA. Based on the preliminary findings of selenium (Se) and gallium (Ga) deficiencies in OA cartilage, tailored nanoparticles based on Se and Ga are designed and validated for their antioxidant ability. GaSex nanoparticles demonstrated significant efficacy in mitigating chondrocyte degeneration and extracellular matrix degradation induced by inflammatory factors and in alleviating cartilage abrasion, hyperalgesia, and abnormal gait in a destabilization of the medial meniscus (DMM) mouse model. Mechanistically, GaSex nanoparticles activated the Nrf2 pathway and competitively inhibited the ubiquitin‐mediated degradation of Gpx4, thus inhibiting ferroptosis. This study systematically designed GaSex nanoparticles based on the imbalance of trace elements within the OA knee joint microenvironment and demonstrated robust antioxidant capabilities and remarkable competitive properties for ubiquitin, thereby providing a novel therapeutic solution for OA treatment.
Phosphate Ion‐Responsive and Calcium Peroxide‐Based Nanomedicine for Bone‐Targeted Treatment of Breast Cancer Bone Metastasis
Authors: Fan Dehui , Li Jing , Li Luwei , An Ming , Yang Hua , Zhou Guoqiang , Gao Shutao , Bottini Massimo , Zhang Jinchao , Ge Kun 
Published: August 2024

AbstractThe treatment of breast cancer bone metastasis is an unresolved clinical challenge, mostly because currently therapeutic approaches cannot simultaneously block the tumor growth and repair the osteolytic bone injuries at the metastatic site. Herein, the study develops a novel nanomedicine to treat breast cancer bone metastasis. The nanomedicine is based on phosphate ion‐responsive and calcium peroxide‐based nanoparticles carrying the bone‐targeting agent zoledronic acid on the surface and loaded with the photosensitizer indocyanine green. Following intravenous administration to a mouse model of breast cancer bone metastasis, the nanoparticles efficiently accumulate at the bone metastasis site, react with free phosphate ions, and form hydroxyapatite nanoaggregates and O2, while releasing the photosensitizer. Hydroxyapatite nanoaggregates elicit the remineralization of the collagenous bone matrix and trigger tumor cell apoptosis. Upon irradiating tumor‐bearing legs with an 808 nm laser source, the O2 and free photosensitizer produced 1O2 by the reaction of the nanoparticles with phosphate ions, further boosting the anti‐tumor effect. Tumor killing hampers the vicious cycle at the site of bone metastasis, translating to osteolysis blockade and further encouraging the remineralization of bone matrix. This work sheds light on the development of a novel, safe, and efficient approach for the treatment of breast cancer bone metastasis.
Biopolymer and Biomimetic Techniques for Triboelectric Nanogenerators (TENGs)
Authors: Liu Zhaoqi , Chen Xiangyu , Wang Zhong Lin 
Published: August 2024

AbstractTriboelectric nanogenerators (TENGs) play a crucial role in attaining sustainable energy for various wearable devices. Polymer materials are essential components of TENGs. Biopolymers are suitable materials for TENGs because of their degradability, natural sourcing, and cost‐effectiveness. Herein, the latest progress in commonly used biopolymers and well‐designed biomimetic techniques for TENG is summarized. The applications of natural rubber, polysaccharides, protein‐based biopolymers, and other common synthetic biopolymers in TENG technology are summarized in detail. Each biopolymer is discussed based on its electrification capability, polarity variations, and specific functionalities as active and functional layers of TENGs. Important biomimetic strategies and related applications of specific biopolymers are also summarized to guide the structural and functional design of TENG. In the future, the study of triboelectric biopolymers may focus on exploring alternative candidates, enhancing charge density, and expanding functionality. Various possible applications of biopolymer‐based TENGs are proposed in this review. By applying biopolymers and related biomimetic methods to TENG devices, the applications of TENG in the fields of healthcare, environmental monitoring, and wearable/implantable electronics can be further promoted.
Si Nanorod Array Integrated Microfluidic Device for Enhanced Extracellular Vesicle Isolation
Authors: Kang Hanyue , Li Cheng , Liu Wenfei , Yang Tongqing , Ma Liang , Sun Na , Xu Xiaobin 
Published: August 2024

AbstractTumor‐derived extracellular vesicles (EVs) have attracted tremendous interest as one of the early cancer diagnostic markers. The major obstacle preventing EV‐based liquid biopsy is the efficient collection of EVs from the complex body fluid environment. This paper introduces a nanorod‐integrated microfluidic chip capable of immunoaffinity‐isolating EVs. Periodic silicon nanorod arrays in zigzag channels are prepared by nanosphere lithography. Nanorod sidewalls provide larger binding sites for antibodies, and their close interspacing to the EV sizes improves the binding probability. The fluid simulation results show that the significant increase in isolation efficiency also comes from the liquid perturbation enhanced by the particular nanorod arrangement. Under optimal operating conditions, plasma samples from patients (n = 14) with different types of cancers (hepatocellular carcinoma, colorectal cancer, and pancreatic adenocarcinoma) to the chip for EV isolation is applied. In this proof‐of‐concept study, the expression level of the epidermal growth factor receptor (EGFR) in isolated EVs is then quantified using droplet digital PCR, showing good diagnostic performance in cancer detection.
Catalytic urea electrooxidation on nickel‐metal hydroxide foams for use in a simplified dialysis device
Authors: Pyka Anthony , Bergsman David S. , Stuve Eric M. 
Published: August 2024

AbstractElectrocatalytic urea removal is a promising technology for artificial kidney dialysis and wastewater treatment. Urea electrooxidation was studied on nickel electrocatalysts modified with Cr, Mo, Mn, and Fe. Mass transfer limits were observed for urea oxidation at physiological concentrations (10 mmol L). Urea oxidation kinetics were explored at higher concentrations (200 mmol L), showing improved performance, but with lower currents per active site. A simplified dialysis model was developed to examine the relationship of mass transfer coefficients and extent of reaction on flowrate, composition, and pH of the reacting stream. For a nickel hydroxide catalyst operating at 1.45 V, 37 , and pH 7.1, the model shows a minimum geometric electrode area of 1314 cm2 is needed to remove 3.75 g urea h with a flow rate of 200 mL min for continuous operation.
Identification and characterization of microplastics in human nasal samples
Authors: Min Hyun Jin , Kim Kyung Soo , Kim Hyunjung , Gong Jiyoung , Jeong Jinyoung 
Published: August 2024

Key points
Human nasal cavity samples were collected, and presence of microplastics were evaluated.
Microplastics were present, and major types were polyethylene, polyester, acrylic polymer, and polypropylene.
Further research is needed regarding microplastics and its clinical impact on human nasal cavity.
Visualization of Electrooxidation on Palladium Single Crystal Surfaces via In Situ Raman Spectroscopy
Authors: Sun Yu‐Lin , Ji Xu , Wang Xue , He Quan‐Feng , Dong Jin‐Chao , Le Jia‐Bo , Li Jian‐Feng 
Published: August 2024

AbstractThe electrooxidation of catalyst surfaces is across various electrocatalytic reactions, directly impacting their activity, stability and selectivity. Precisely characterizing the electrooxidation on well‐defined surfaces is essential to understanding electrocatalytic reactions comprehensively. Herein, we employed in situ Raman spectroscopy to monitor the electrooxidation process of palladium single crystal. Our findings reveal that the Pd surface's initial electrooxidation process involves forming *OH intermediate and ClO4− ions facilitate the deprotonation process, leading to the formation of PdOx. Subsequently, under deep electrooxidation potential range, the oxygen atoms within PdOx contribute to creating surface‐bound peroxide species, ultimately resulting in oxygen generation. The adsorption strength of *OH and the coverage of ClO4− can be adjusted by the controllable electronic effect, resulting in different oxidation rates. This study offers valuable insights into elucidating the electrooxidation mechanisms underlying a range of electrocatalytic reactions, thereby contributing to the rational design of catalysts.
Size‐Increased All‐Phenylene Molecular Spoked Wheels – A Combined Theoretical and Experimental Approach
Authors: Krämer Philipp , Kohn Julia , Hofmeister David Ari , Kersten Maximilian , Sterzenbach Christopher , Gres Antonia , Hansen Andreas , Jester Stefan‐Sven , Grimme Stefan , Höger Sigurd 
Published: August 2024

AbstractA lateral expansion of molecular spoked wheels (MSWs) based on an all‐phenylene backbone is described. The MSWs contain a central hub, six spokes, and a rim that is formed by a sixfold Yamamoto coupling of the respective non‐cyclized dodecabromo precursor yielding MSWs with up to 30 phenylene rings in the perimeter. Attempts to prepare compounds of such size without flexible side groups at the spokes were unsuccessful, most probably due to an aggregation and accompanying oligomerization of the precursors during the cyclization. To overcome these problems, fluorene units are inserted into the spokes. These contain additional alkyl chains and lead to a curvature of the wheels. Quantum chemical calculations on the mechanism of the Yamamoto coupling lead to geometry and strain‐related criteria for the successful rim closure to the respective MSW. Subsequently, MSWs are prepared with four and even six phenylene units at each edge of the hexagonal wheels. The resulting MSWs are characterized by spectroscopic methods, and additionally some of them are visualized via scanning tunneling microscopy (STM).
Robust G‐Quadruplex Dimer‐Guided Transmembrane DNA Nanovehicles for Targeted Payload Delivery
Authors: Liu Chengbin , Wang Qiwei , Shi Lili , Li Tao 
Published: August 2024

AbstractHere we report a robust G‐quadruplex (G4) dimer‐guided transmembrane DNA nanovehicle for targeted payload delivery, based on dimeric G4‐proximized aptamers that efficiently target transferrin receptors (TfR) over‐expressed on cancer cell surface. It enables the cancer‐specific delivery of fluorescent G4 ligands and therapeutic drugs for cellular imaging and treatment.
Nanosize Controllable Two‐Dimensional (Cu–S)n Metal–Organic Framework Hybrid With Reduced Graphene Oxide by In Situ Microwave and Hydrothermal Synthesis for Electrochemical Neurotransmitter Detection
Authors: Lin Xiao‐Yuan , Yu Yuan‐Hsiang , Li Si‐Yu , Teng Kun‐Ling , Chen Hsiu‐Hui , Liu Yen‐Hsiang , Lu Kuang‐Lieh 
Published: August 2024

ABSTRACTWe present a groundbreaking technique for controllably synthesizing nanosized semiconductive two‐dimensional (2D) (Cu–S)n metal–organic framework (MOF)/graphene nanocomposites for electrochemical sensing of neurotransmitter 2‐phenethylamine (PEA). The (Cu–S)n MOF size is controlled by graphene oxide proportions, enhancing electrocatalytic activity. The modified electrode exhibits a surface area increase from 0.0639 to 0.1906 cm2 and impressive limit of detection (0.0156 and 0.004 μM) within linear ranges of 15–200 μM and 1–10 μM, offering exceptional selectivity, reproducibility, and repeatability for biosensing.
Photoactive Donor–Acceptor Covalent Organic Framework Material for Synergistic Cyclization Approach to Imidazole Derivatives
Authors: Sun Xiaoman , Su Qing , Luo Kexin , Liu Shufang , Ren Hao , Wu Qiaolin 
Published: August 2024

ABSTRACTAs one of the most potential platforms for heterogeneous catalysis, two‐dimensional porphyrin‐based covalent organic frameworks (COFs) have attracted great research interests. In this work, following the correlation of COF structure and their performance, a type of donor–acceptor 2D COF (Por‐COF‐Zn) based on porphyrin and thiophene units was designed and easily constructed by one‐pot method using 5,10,15,20‐tetra‐(4‐aminophenyl)porphyrin (TAPP), thieno[3,2‐b]thiophene‐2,5‐dicarbaldehyde, and zinc acetate. The as‐synthesized COF material is tested to show high crystallinity and good thermal and chemical stability. The Brunauer–Emmett–Teller (BET) measure results show that the specific surface area of Por‐COF‐Zn is 413.6 m2g−1, and the pore volume is 0.279 cm3g−1. Transient photocurrent response and EIS measurement also demonstrate that Por‐COF‐Zn exhibits an efficient separation of photogenerated electron/hole pairs. The photocatalytic performance of the resulted COF was further evaluated by using intramolecular cyclization of N‐phenyl‐o‐phenylenediamine and benzaldehyde to form benzimidazole derivative. The catalyst system exhibited good to high conversion efficiency, moderate substrate applicability, and excellent stability and recyclability for the catalytic cyclization approach of benzimidazoles. The catalytic mechanism should be contributed to the synergistic effect of organic framework and metallic zinc. Our current work also provides valuable information for understanding COF‐based photocatalytic systems and further highlight new insights to meet new challenges of heterogeneous photocatalysis.