bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monofunctional Platinum(II) Complexes with Potent Tumor Cell Growth Inhibitory Activity: The Effect of a Hydrogen‐Bond Donor/Acceptor N‐Heterocyclic Ligand
Authors: Margiotta Nicola , Savino Salvatore , Gandin Valentina , Marzano Christine , Natile Giovanni 
Published: May 2014

AbstractIn this paper we investigate the possibility of further increase the role of the N‐donor aromatic base in antitumor Hollis‐type compounds by conferring the possibility to act as a hydrogen‐bond donor/acceptor. Therefore, we synthesized the PtIIcomplexcis‐[PtCl(NH3)2(naph)]NO3(1) containing the 1,8‐naphthyridine (naph) ligand. The naphthyridine ligand is generally monodentate, and the second nitrogen atom can act as H‐bond donor/acceptor depending upon its protonation state. The possibility of forming such an H‐bond could be crucial in the interaction of the drug with DNA or proteins. Apart from the synthesis of the compound, in this study we evaluated its in vitro antitumor activity in a wide panel of tumor cell lines, also including cells selected for their sensitivity/resistance to oxaliplatin, which was compared with that of previously reported complex2([PtI(2,9‐dimethyl‐1,10‐phenanthroline)(1‐methyl‐cytosine)]I) and oxaliplatin and cisplatin as reference compounds. The cytotoxicity data were correlated with the cellular uptake and the DNA platination levels. Finally, the reactivity of1towards guanosine 5′‐monophosphate (5’‐GMP) and glutathione was investigated to provide insights into its mechanism of action.
Aberrant methylation and decreased expression of the TGF‐β/Smad target gene FBXO32 in esophageal squamous cell carcinoma
Authors: Guo Wei , Zhang Minghui , Shen Supeng , Guo Yanli , Kuang Gang , Yang Zhibin , Dong Zhiming 
Published: May 2014

BACKGROUNDF‐box protein 32 (FBXO32) (also known as atrogin‐1), a member of the F‐box protein family, has recently been identified as a transforming growth factor beta (TGF‐β)/Smad target gene involved in regulating cell survival, and it may be transcriptionally silenced by epigenetic mechanisms in some kinds of carcinomas, yet its role in esophageal squamous cell carcinoma (ESCC) has not been defined.METHODSThe role of FBXO32 in ESCC and the correlation of FBXO32 methylation with a series of pathologic parameters were studied in a large cohort of patients with ESCC.RESULTSDecreased messenger RNA (mRNA) expression and protein expression of FBXO32 were observed in esophageal cancer cell lines, and the silencing of FBXO32 could be reversed by treatment with 5‐aza‐2′‐deoxycytidine or trichostatin A in the TE13 cell line. In addition, aberrant methylation of FBXO32 and histone deacetylation was capable of suppressing FBXO32 mRNA and protein expression in TE13 cells. Decreased mRNA and protein expression of FBXO32 was observed in ESCC tumor tissues and was associated with FBXO32 promoter methylation status. A positive correlation between FBXO32 and phosphorylated SMAD family members 2 and 3 expression and Smad4 protein expression also was observed in clinical specimens. FBXO32 methylation status and protein expression were independently associated with survival in patients with ESCC.CONCLUSIONSFBXO32 may be a functional tumor suppressor. Its inactivation through promoter methylation could play an important role in ESCC carcinogenesis, and reactivation of the FBXO32 gene may have therapeutic potential and might be used as a prognostic marker for patients with ESCC. Cancer 2014;120:2412–2423. © 2014 American Cancer Society.
Effects of implant neck design on primary stability and overload in a type IV mandibular bone
Authors: Chou I‐Chiang , Lee Shyh‐Yuan , Jiang Cho‐Pei 
Published: May 2014

SUMMARYThis study investigates the effect of implant neck design on primary stability and overload using 3D finite element analysis. Four commercial dental implants and mandibular segments are created. Various parameters including the osseointegration condition (non‐osseointegration and full osseointegration), force direction (vertical and horizontal), and cortical bone thickness (Tc = 0.3, 0.5, and 1 mm) are considered. The vertical and horizontal forces, 500 N and 250 N, are statically applied at the top of the platform, respectively. Micromotion and von Mises stress are employed to evaluate the risk of osseointegration and bone fatigue before osseointegration condition. After osseointegration, the principal stress is used to analyze the bone overload. Maximal von Mises stress and micromotion of the peri‐implant bone decreased as cortical bone thickness increased. Horizontal force induces stress concentration in the bone around the implant neck easier than that of vertical force, and it may result in crestal bone loss. Thinner cortical bone should avoid dental implantation because it causes a noteworthy larger micromotion and stress concentration in cortical bone in particular Tc less than 0.3 mm. Copyright © 2014 John Wiley & Sons, Ltd.
Aluminum Manganese Oxides with Mixed Crystal Structure: High‐Energy‐Density Cathodes for Rechargeable Sodium Batteries
Authors: Han Dong‐Wook , Ku Jun‐Hwan , Kim Ryoung‐Hee , Yun Dong‐Jin , Lee Seok‐Soo , Doo Seok‐Gwang 
Published: May 2014

AbstractWe report a new discovery for enhancing the energy density of manganese oxide (NaxMnO2) cathode materials for sodium rechargeable batteries by incorporation of aluminum. The Al incorporation results in NaAl0.1Mn0.9O2 with a mixture of tunnel and layered crystal structures. NaAl0.1Mn0.9O2 shows a much higher initial discharge capacity and superior cycling performance compared to pristine Na0.65MnO2. We ascribe this enhancement in performance to the formation of a new orthorhombic layered NaMnO2 phase merged with a small amount of tunnel Na0.44MnO2 phase in NaAl0.1Mn0.9O2, and to improvements in the surface stability of the NaAl0.1Mn0.9O2 particles caused by the formation of AlO bonds on their surfaces. Our findings regarding the phase transformation and structure stabilization induced by incorporation of aluminum, closely related to the structural analogy between orthorhombic Na0.44MnO2 and NaAl0.1Mn0.9O2, suggest a strategy for achieving sodium rechargeable batteries with high energy density and stability.
RENi9In2 (RE = Rare‐Earth Metal): Crystal Chemistry, Hydrogen Absorption, and Magnetic Properties
Authors: Bigun Inna , Dzevenko Mariya , Havela Ladislav , Kalychak Yaroslav 
Published: May 2014

AbstractA series of RENi9In2 compounds (RE = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho and Er) and their hydrides, RENi9In2Hx (RE = La, Ce, Pr, Nd and Eu), have been synthesized and characterized using X‐ray powder diffraction and magnetization measurements. All studied compounds adopt the YNi9In2 structure type [space group (SG) P4/mbm]. The lattice parameters decrease from La to Er in accordance with the lanthanide contraction. Their structure can be visualized as a packing of rare‐earth 20‐vertices polyhedra and Ni‐centred icosahedra in an AuCu‐like arrangement. The hydrogenation results in the formation of RENi9In2Hx with slightly expanded unit cells within the YNi9In2 structure type. Possible hydrogen positions in EuNi9In2H3.4 are proposed. Most of the compounds and their hydrides (with Pr and Nd) exhibit Curie–Weiss behaviour. No magnetic ordering could be detected down to T = 2 K. EuNi9In2 reveals ferromagnetism below approximately 40 K, which might be due to a secondary phase. Its hydride is Pauli paramagnetic, thus indicating the Eu3+ state. YNi9In2 and LaNi9In2 are Pauli paramagnets. The studied phases are typical metallic conductors.
[(1,3‐Bis{2,6‐bis(diphenylmethyl)‐4‐methylphenyl}imidazole‐2‐ylidene)PdCl2(NEt3)]: “Throwing Away” a Different Ancillary Ligand to Enhance the Catalytic Activity at Room Temperature
Authors: Guest Daniel , Chen Ming‐Tsz , Tizzard Graham J. , Coles Simon J. , Turner Michael Lewis , Navarro Oscar 
Published: May 2014

AbstractInvited for the cover of this issue is the group of Oscar Navarro at the University of Sussex, UK. The cover image shows the stage in catalyst design when the choice of ancillary ligands to accompany the main “working” ligand is made. The use of triethylamine (TEA) as “throw‐away” ligand, unveiling the catalytically active LnPd(0) species, leads to decreased catalyst loadings, and no inert atmosphere is required in Buchwald–Hartwig amination reactions.
The Size‐Dependent Phase Transition of LiFePO4 Particles during Charging and Discharging in Lithium‐Ion Batteries
Authors: Li De , Liu Xizheng , Zhou Haoshen 
Published: May 2014

AbstractIn this work, LiFePO4 nanoparticles are investigated by electrochemical impedance spectroscopy (EIS), and the tilt angle in the linear Warburg region is analyzed to give a particle‐by‐particle phase‐transition model. In this model, the nanoparticles are converted between the two phases quickly, leading to only two kinds of single‐phase nanoparticles. This model is quite different from the hybrid model for microparticles in our previous work, which could be interpreted within the size‐dependent solubility limit that was determined by using in situ X‐ray diffraction (XRD). For LiFePO4 nanoparticles, the high solubility limit will facilitate the phase transition, whereas the small particles for LiFePO4 microparticles will retard the phase transition and the relaxation process.
A Low Cost Large‐Area Solid Oxide Cells Fabrication Technology based on Aqueous Co‐Tape Casting and Co‐Sintering
Authors: Zhou J. , Liu Q. , Sun Q. , Hwa Chan S. 
Published: May 2014

AbstractAqueous‐based tape casting is a low‐cost and environment friendly technology. In this paper, large‐area fuel electrode‐supported solid oxide cells (SOCs) were fabricated by this technology in conjunction with co‐sintering process. A 10 cm × 10 cm single cell with NiO/Zr0.92Y0.08O2–δ fuel electrode, Zr0.92Y0.08O2–δ electrolyte and La0.6Sr0.4Co0.2Fe0.8O3+δ/Ce0.9Gd0.1O2+δ air electrode has been successfully developed with improved electrode microstructure and hence the cell performance with the maximum power density of 534 mW cm–2 at 850 °C with humidified H2 as the fuel and air as the oxidant has been achieved. The optimal slurry formulations used in the fabrication of SOC were summarized for future reference purpose.
Enhancement of the Passive Direct Methanol Fuel Cells Performance by Modification of the Cathode Microporous Layer Using Carbon Nanofibers
Authors: Abdelkareem M. A. , Kasem E. T. , Nakagawa N. , Abdelghani E. A. M. , Elzatahry A. A. , Khalil K. A. , Barakat N. A. M. 
Published: May 2014

AbstractMass transfer is a key parameter affecting the performance of the passive direct methanol fuel cells (DMFCs), which work under natural convection. In this study, effect of carbon nanofibers (CNFs) addition to the cathode microporous layer (MPL) on the performance of the passive DMFCs was investigated. The results indicated that CNFs content has a significant influence on both of the mass transport and the electrochemical surface area (ECSA). Interestingly, addition of the CNFs (20 wt.%) leads to increase the power density of the passive DMFC to 160% compared to pristine carbon black MPL. At low current density, the CNFs content has no influence on the performance, while at high current density the maximum performance can be obtained at 20 wt.% CNFs then the performance decreases with further increase in the CNFs content. Although the highest catalyst utilization is observed at 40 wt.% CNFs, a maximum power density of 36 mW cm–2 can be obtained at 20 wt.% CNFs and this is related to the significant effect of the mass transfer resistance under the passive operation conditions. Overall, addition of CNFs to the MPL can be considered an effective strategy to modify the passive DMFCs performance.
Self and carer perspectives of quality of life in dementia using the QoL‐AD
Authors: Orgeta Vasiliki , Orrell Martin , Hounsome Barry , Woods Bob ,   in collaboration with the REMCARE team
Published: May 2014

ObjectiveQuality of life (QoL) is one of the most important outcomes in improving well‐being in people with dementia (PwD). The primary aim of the present study was to compare self and carer ratings of QoL in PwD and to identify the most important factors influencing self and carer ratings.MethodsWe conducted a cross‐sectional analytic study of 488 dyads using the Quality of Life in Alzheimer's Disease scale, demographics, data on self‐rated health, and clinical characteristics.ResultsHigher levels of self‐rated health in PwD were associated with higher self‐rated QoL after controlling for depression and activities of daily living. When the carer experienced less stress related to caregiving, the PwD reported better QoL. Higher carer‐rated QoL was associated with less carer stress, better health for the family carer, and the PwD being of younger age. When carers lived with the PwD, and reported lower levels of depression and better functional ability for their relative, carer‐rated QoL was higher.ConclusionsThe self‐rated health of PwD and carers influences the ratings they make of the QoL of the PwD indicating that it is an important influence on QoL in this population. Copyright © 2014 John Wiley & Sons, Ltd.
Quantifying fibrosis in head and neck cancer treatment: An overview
Authors: Moloney Emma C. , Brunner Markus , Alexander Ashlin J. , Clark Jonathan 
Published: May 2014

AbstractBackgroundFibrosis is a common late complication of radiotherapy and/or surgical treatment for head and neck cancers. Fibrosis is difficult to quantify and formal methods of measure are not well recognized. The purpose of this review was to summarize the methods available to quantify neck fibrosis.MethodsA PubMed search of articles was carried out using key words “neck” and “fibrosis.”ResultsMany methods have been used to assess fibrosis, however, there is no preferred methodology. Specific to neck fibrosis, most studies have relied upon hand palpation rating scales. Indentation and suction techniques have been used to mechanically quantify neck fibrosis. There is scope to develop applications of ultrasound, dielectric, bioimpedance, and MRI techniques for use in the neck region.ConclusionQuantitative assessment of neck fibrosis is sought after in order to compare treatment regimens and improve quality of life outcomes in patients with head and neck cancer. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1225–1231, 2015
Endonasal endoscopic surgery for squamous cell carcinoma of the sinonasal cavities and skull base: Oncologic outcomes based on treatment strategy and tumor etiology
Authors: de Almeida John R. , Su Shirley Y. , Koutourousiou Maria , Vaz Guimaraes Filho Francisco , Fernandez Miranda Juan C. , Wang Eric W. , Gardner Paul A. , Snyderman Carl H. 
Published: May 2014

AbstractBackgroundOncologic outcomes for sinonasal and skull base squamous cell carcinoma (SCC) treated with an endoscopic endonasal approach (EEA) needs investigation.MethodsPatients with SCC treated with EEA were stratified by treatment strategy and tumor etiology and reviewed.ResultsThirty‐four patients were treated with EEA, or which 27 had definitive resection and 7 had debulking surgery. In the definitive group, 17 had de novo tumors and 10 had tumors arising from inverted papilloma. Definitive resection was associated with better 5‐year disease‐free survival (DFS) and overall survival (OS) than debulking (62% vs 17%; p = .02; and 78% vs 30%; p = .03). Patients with de novo tumors had similar 5‐year DFS and OS to those arising from inverted papilloma (62% vs 62%; p = .75; and 75% vs 86%; p = .24).ConclusionDefinitive resection of sinonasal SCC with EEA provides sound oncologic outcomes. SCC arising from inverted papilloma does not have prognostic significance. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1163–1169, 2015
Preliminary investigation on hemocompatibility of poly(vinylidene fluoride) membrane grafted with acryloylmorpholine via ATRP
Authors: Shen Xiang , Liu Jie , Feng Xia , Zhao Yiping , Chen Li 
Published: May 2014

AbstractThis work provides a promising way to improve the hemocompatibility of PVDF membrane. An amphiphilic copolymer (PVDF‐g‐PACMO) having PVDF backbones and poly(N‐acryloylmorpholine) (PACMO) side chains was synthesized via atom transfer radical polymerization (ATRP). It is found that the grafting degree of the PACMO increases linearly with the increase of ACMO concentration in the reaction solution. The PVDF‐g‐PACMO membrane was prepared via immersed phase inversion method. The structure and performances were evaluated by X‐ray photoelectron spectroscopy, field emission scanning electron microscopy, water contact angle, and filtration experiment. The hemocompatibility of the membranes were preliminarily investigated by protein adsorption, platelet adhesion, anticoagulant evaluation and hemolysis test. The results indicate that the PVDF membrane functionalized by PACMO can suppress the protein adsorption and platelet adhesion, and shows an improved hemocompatibility. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 683–692, 2015.
Electrospun polyamide–polyethylene glycol nanofibers for headspace solid‐phase microextration
Authors: Bagheri Habib , Najarzadekan Hamid , Roostaie Ali 
Published: May 2014

A solution of polyamide (PA) containing polyethylene glycol (PEG) as a side low‐molecular‐weight polymer was electrospun. After synthesizing the PA–PEG nanofibers, the constituent was subsequently removed (modified PA) and confirmed by Fourier transform infrared spectroscopy. The scanning electron microscopy images showed an average diameter of 640 and 148 nm for PA and PA–PEG coatings, respectively, while the latter coating structure was more homogeneous and porous. The extraction efficiencies of PA, PA–PEG, and the modified PA fiber coatings were assayed by headspace solid‐phase microextraction of a number of chlorophenols from real water samples followed by their determination by gas chromatography with mass spectrometry. To prepare the most appropriate coatings, the amounts and the flow rate of the electrospinning solution were investigated. Various extraction parameters, such as the salt content, desorption condition, extraction temperature, and time were optimized. The limits of detection of the method were in the range of 0.8–25 ng/L, while the RSDs at two concentration levels of 200 and 80 ng/L were between 2.1 and 12.2%. The analysis of real water samples led to relative recoveries between 85 and 98% with a linearity of 8–1500 ng/L.
Characteristics of the Children's Revised Impact of Event Scale in a Clinically Referred Dutch Sample
Authors: Verlinden Eva , van Meijel Els P. M. , Opmeer Brent C. , Beer Renée , de Roos Carlijn , Bicanic Iva A. E. , Lamers‐Winkelman Francien , Olff Miranda , Boer Frits , Lindauer Ramón J. L. 
Published: May 2014

AbstractEarly identification of posttraumatic stress disorder (PTSD) in children is important to offer them appropriate and timely treatment. The Children's Revised Impact of Event Scale (CRIES) is a brief self‐report measure designed to screen children for PTSD. Research regarding the diagnostic validity of the CRIES is still insufficient, has been restricted to specific populations, and sample sizes have often been small. This study evaluated the reliability and validity of the 8‐item (CRIES‐8) and 13‐item (CRIES‐13) versions of the CRIES in a large clinically referred sample. The measure was completed by 395 Dutch children (7–18 years) who had experienced a wide variety of traumatic events. PTSD was assessed using the Anxiety Disorders Interview Schedule for DSM‐IV: Child and Parent version. A cutoff score of 17 on the CRIES‐8 and 30 on the CRIES‐13 emerged as the best balance between sensitivity and specificity, and correctly classified 78%–81% of all children. The CRIES‐13 outperformed the CRIES‐8, in that the overall efficiency of the CRIES‐13 was slightly superior (.81 and .78, respectively). The CRIES appears to be a reliable and valid measure, which gives clinicians a brief and user‐friendly instrument to identify children who may have PTSD and offer them appropriate and timely treatment.
Broadband spin‐controlled surface plasmon polariton launching and radiation via L‐shaped optical slot nanoantennas
Authors: Yang Jing , Zhou Shuxiang , Hu Chuang , Zhang Weiwei , Xiao Xiao , Zhang Jiasen 
Published: May 2014

AbstractBroadband spin‐controlled surface plasmon polariton (SPP) launching and radiation via L‐shaped optical slot nanoantennas are proposed and demonstrated experimentally. The phase retardation and spectra overlapping between two resonant plasmon modes in the L‐shaped optical slot nanoantenna lie at the origin of this effect. SPP launching in two perpendicular directions are controlled by the spin of the incident light. Broadband directional launching of SPPs is achieved and the extinction ratio keeps larger than 7 dB within a wavelength range of 150 nm. Furthermore, the photon spin of SPP radiation via the L‐shaped optical slot nanoantennas is controlled by SPP propagation directions. These investigations provide a route for spin‐controlled nanophotonic applications.
Reversible fixation and release of carbon dioxide with a binary system consisting of polyethylene glycol and polystyrene‐bearing cyclic amidine pendant group
Authors: Sakuragi Mina , Aoyagi Naoto , Furusho Yoshio , Endo Takeshi 
Published: May 2014

ABSTRACTIn this study, we investigated the CO2‐capture/release behavior of the polystyrene‐bearing cyclic amidine pendant groups, which was synthesized via free radical polymerization of HCl salt of the corresponding styrene monomer followed by neutralization. For comparison, we also prepared the polystyrene bearing N‐formyl‐1,3‐propanediamine pendant groups through the hydrolysis of the cyclic amidine group by treatment with an alkaline solution. First, we examined the CO2‐capture/release behaviors of the amidine and amine monomers in aqueous solution in terms of conductivity. The conductivity of a wet DMSO solution of the amidine monomer increased upon CO2 bubbling at 25 °C and reached a stationary value of about 11 mS/m, which indicated the formation of the bicarbonate salt. Conversely, the conductivity decreased to its original value upon N2 bubbling at 50 °C, reflecting the complete release of the trapped CO2 molecules. Both solutions showed the changes in the conductivity with quick responses, and no appreciable difference was observed between them. We then investigated the CO2‐capture/release behaviors of the amidine and amine polymers, by taking advantage of the binary system with polyethylene glycol, and found that the binary system with the amidine polymer captured and released CO2 more efficiently than that with the amine polymer. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 2025–2031
The study of large semiconducting boron doped single crystal diamond sectorial structure
Authors: Chepugov A. , Ivakhnenko S. , Garashchenko V. 
Published: May 2014

AbstractThe sectorial structure of semiconductor single‐crystal diamond grown at high pressure and temperature was considered. Influence of crystal structure on shape of IR‐absorption maps and photoluminescence glow were studied. The distribution of boron impurity and its concentration in the areas which belonging to different growth sectors were measured. The analysis of the effect of the conditions of type IIb crystal growth at HPHT on their structure was performed, conditions for getting the most homogeneous samples were defined. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)