bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimalarial activity of caffeine, orally administered with a lipid-based formulation in a Murine model
Authors: Fadare O.A. , Omisore N.O. , Fadare R.Y. , Oduwale A.I. , Awofisayo O. , Ogundolie F.A. , Salaria D. , Rolta R. , Adesanwo J.K. 
Published: August 2024

Despite Caffeine being known essentially for its psychoactive properties, an attempt was made in this study to investigate its potential antimalarial activity considering that it's an alkaloid and that the malaria parasite is a purine auxotroph. In the baseline experiment, caffeine was administered at three doses (5, 10 and 20 mg/kg) once daily in suppressive and curative models. The observed chemosuppression activity was comparable to that of chloroquine (CQ) in both experiments. In the baseline suppressive experiment, a chemosuppression of 70.39% for CQ (at 10 mg/kg) was observed, while caffeine had 78.90%, 80.73% and 81.95% at the respective doses. However, the survival index estimated based on the rate of survival of the experimental animals for 28 days post infection, was very low (33%, 29% and 43% respectively, and the same trend was observed in the baseline curative experiment). This initial result showed that caffeine had potential as an antimalarial agent relative to the standard drug, chloroquine, and the lipid-based formulation must have played a role in ensuring that the caffeine had enhanced bioavailability. A follow-up experiment was conducted in which the caffeine was administered twice daily (at 20 mg/kg) in suppressive and curative experiments. The observed chemosuppression in the suppressive test (with twice daily administration), showed that caffeine at 20 mg/kg had similar antiplasmodial activity with chloroquine (10 mg/kg). Both had chemosuppression of 53.6% and 54.36%, respectively and a survival index of 100% was recorded for both compounds. The curative experiment that followed (also with twice daily administration) further showed that caffeine compares favourably with chloroquine. Caffeine exhibited 45.92%, 72.00%, 69.87% chemosuppression as compared to chloroquine with 20.97%, 65.64%, 60.95% for 3, 5 and 7 days of treatment respectively. Caffeine's survival index was very high and much better than what was observed in the once daily administration experiment. A survival index of 93% was observed in the twice daily administration curative experiment against the 53% survival index observed in the once daily curative experiment. It is assumed that apart from the fact that the lipid-based oral delivery system ensured that the caffeine was effectively absorbed, bypassing liver first-pass, the twice daily administration also helped to sustain large concentrations of the caffeine in the blood to offset the rapid clearance that caffeine is known for.
Isolation, characterization of ethanol-tolerant yeast from decaying oranges and pineapples for the production of bioethanol: A waste management option
Authors: Adeyemo S.F. , Ajao A.B. , Ajayi O.S. , Aina M.O. , Afonja M.A. , Abimbola O.G. , Adeyemo S.M. 
Published: August 2024

The increase in population has led to a high demand for petroleum, a nonrenewable fossil fuel; excessive use of which results in global warming causing health and environmental problems. Therefore, there is a need for urgent replacement with renewable energy such as Bioethanol. The study focuses on isolating, identifying, and confirming ethanol-tolerant yeasts from decaying oranges and pineapples obtained from local markets within the Ibadan Metropolis. Standard morphological, biochemical, analytical profile index (API), and physicochemical tests were carried out on the yeasts and ethanol produced respectively. The fruits were crushed, juice extracted and yeasts isolated with Yeast Extract Agar (YEA) and screened for ethanol, NaCl, and antibiotics tolerance. The brix level, titratable acidity, pH, and specific gravity of the ethanol produced were determined during fermentation from day zero to fourteen. The yeasts isolated were Candida valida, Pichia meri, Saccharomyces cerevisiae, Kluveromyces fragilis, and K. marxianus. The pH and TTA were monitored from day 0 to day 14, a decrease in pH from 4.57 to 3.07 and an increase in TTA from 0.03 to 0.51 was observed as fermentation progressed. There was a significant reduction in reducing sugar level (brix) from 1.10 to 0.20; and specific gravity from 1.036 on day 0 to 1.005 on day 14. The lower the specific gravity, the higher the alcohol content. This means that the alcohol content increases as the specific gravity reduces. Moreover, the pH and the specific gravity reduced, and the ethanol content increased with fermentation time. This research concluded that decaying oranges and pineapples can serve as substrates for isolating of ethanol-tolerant yeasts and producing bioethanol, thus presenting a viable waste management solution.
Evaluation of antifungal activity of lactic acid bacteria from locally sourced yoghurts on isolates of <i>Candida Albicans</i> from cases of vaginitis
Authors: Lionel Okunye Olufemi , Adegboyega Idowu Philip , Babalola Caroline Olufunke , Comfort Kotun Bunmi , Seun Ayedun Joshua , Ann Adesanya Ayomide , Teniola Kolade Titilayo , Chijioke Iloka Brenda 
Published: August 2024

This study assessed antifungal activity of lactic acid bacteria from locally made yoghurts on isolates of candida albicans from cases of vaginitis. Locally sourced yoghurt samples were cultured on MRS agar and incubated anaerobically at optimum temperature for the isolation of Lactic Acid Bacteria. The pH and total viable counts parameters of the isolates from the samples were determined. Isolates of Candida albicans from cases of vaginitis collected were biochemically confirmed after SDA plated. The isolates were exposed to antifungal agents with varied concentrations and thereafter, challenged with Lactic Acid Bacteria laden yoghurt samples prepared in varied concentration on MRS agar overlayered with SDA. Plasmid DNA of the LAB isolates were determined. The isolates of Candida albicans exhibited 100% resistance to conventional antifungal agents exposed with the exception of Candida albicans 1 that were susceptible to all the antifungal agents while Candida albicans 4 was susceptible to amphotericin B, fluconazole, and nystatin. Three(3) of the four (4) isolates of Candida albicans challenged with Habib (LABHAY) and Tunik(LAB TY ) yoghurt were 100% susceptible the LAB laden yoghurt samples while Candida albicans isolates 3 (Ca3) were (100%) resistant to LABHAY and LAB TY. Of the the four(4) isolates of Candida albicans were(100%) susceptible to Cedaar (LABCY) and Fan milk(LABFM) yoghurt and while Candida albicans isolates number 3 (Ca3) exhibited resistance to LABCY and LABFM. Lactic Acid Bacteria in this study, exhibited remarkable antifungal activity on Candida albicans isolates from cases of vaginitis. This property could be exploited as a bio-protective and therapeutic option, for cases of Candida albicans and fungi with related features.
Sustainability and inclusion from African perspectives
Authors: Tchombe Therese Mungah Shalo 
Published: August 2024

Sustainability entails a change in the exploitation of resources while maintaining essential ecological processes and life support systems, preserving genetic diversity, and ensuring the utilisation of species and ecosystems. Effective realisation of sustainability requires the implementation of inclusive practices, whereby diversity is embraced from the educational, economic, social, cultural, and psychological dimensions of human life and climate change. Commenting on the African perspective, the need to search for alternative solutions to Africa’s development challenges calls for a critical examination of what sustainability and inclusion mean for Africans and how these can impact their lives in the 21st century. Sustainability and inclusion from African perspectives, therefore, raise concerns about the cultural, socioeconomic, political, health, spiritual, environmental, and socially responsible processes, underpinned by Africentric humanistic philosophies of communalism and socialism. The discussions of this paper posit a paradigm shift from Eurocentric scientific and pedagogical principles. In this light, the paper critically situates the significance of Ujamaa and Ubuntu, African philosophies to illustrate that sustainability and inclusion, are exemplified by harmonious relationship between the human being and nature. Nonetheless the changing context of Africa poses some new challenges for sustainability and inclusion within African cultures. Development issues ought to be people-driven, inclusively focusing on African values, guided also by relevant orientations from Africa’s Agenda 2063 of “an integrated, prosperous and peaceful Africa, driven by its citizens and representing a dynamic force in the international arena”.
Distal Femur Morphological Discrepancy Compared with Total Knee Arthroplasty Implants in Indonesia
Authors: Sentana Okkie Mharga , Utomo Pamudji 
Published: August 2024

Background: The prosthesis of knee joint in total knee arthroplasty (TKA) can give better fixation and stabilization if it’s chosen properly. Most of prosthesis have been designed to be compatible with western population, not for Asian population. Whether the implant size need to be adjusted with ethnics and gender still being a controversy. Aim: to define whether the morphology of Distal Femur, among men and women in Indonesia have discrepancy and to assess compatibility of the prosthesis size in IndonesiaMethods: This study was a descriptive cross-sectional study that conducted at Prof. Dr. R Soeharso’s Orthopaedic Hospital – Surakarta, Indonesia, using purposive quota sampling methods. The inclusion criteria MRI knee joint of men and women (age ≥ 18 years old) which have soft tissue injury of knee joint. The morphological measurement of Distal Femur with the use of certain Software. Then, the data were analyzed with SPSS ver.17 using independent T-Test.Results: Among 130 patients, we found that Women’s fML were narrower than men. While the ratio aspect of femur implants compared to gender, showed that it was not compatible for men, but more compatible for women.Conclusion: There is discrepancy of morphological size of Distal Femur among men and women in Indonesia. It causes incompatibility of using TKA implant in men patients in Indonesia, which more suitable for women size.
Pengaruh Pengetahuan Perpajakan, Sanksi Pajak, Kewajiban Moral, dan Tingkat Pendidikan terhadap Kepatuhan Wajib Pajak Orang Pribadi di Pamekasan
Authors: Haizumah Syibriya Fatin , Hayati Nur 
Published: August 2024

Penelitian ini bertujuan untuk menguji pengaruh Faktor-faktor kepatuhan wajib pajak yang terdiri dari pengetahuan perpajakan, sanksi pajak, kewajiban moral, dan tingkat pendidikan terhadap kepatuhan wajib pajak orang pribadi di Kabupaten Pamekasan yang terdaftar di KPP Pratama Pamekasan. Penelitian ini dilakukan dengan metode kuantitatif dengan menggunakan analisis regresi linier berganda. Hasil penelitian ini menunjukkan bahwa (1) pengetahuan perpajakan berpengaruh positif terhadap kepatuhan wajib pajak orang pribadi, (2) sanksi pajak tidak berpengaruh terhadap kepatuhan wajib pajak orang pribadi, (3) kewajiban moral berpengaruh positif terhadap kepatuhan wajib pajak orang pribadi, dan (4) tingkat pendidikan tidak berpengaruhÂ terhadap kepatuhan wajib pajak orang pribadi.
Pengaruh Debt to Equity Ratio, Price to Earning Ratio, Return on Equity Ratio terhadap Return Saham pada Perusahaan Indeks IDX30
Authors: Rosyafah Siti , Iman Nurul , Fatmawati Nur Indah 
Published: August 2024

Penelitian ini bertujuan untuk menguji dan membuktikan pengaruh Debt to Equity Ratio, Price to Earning Ratio, Return on Equity Â Ratio terhadap Return Saham Pada Perusahaan Indeks IDX30 yang terdaftar di Bursa Efek Indonesia Periode 2018-2020. Metode penelitian ini menggunakan pendekatan kuantitatif. Data penelitian ini merupakan data sekunder berupa laporan keuangan perusahaan dan menganalisis data menggunakan SPSS versi 24. Hasil penelitian menunjukkan pada pengujian secara parsial diketahui Debt to Equity Ratio memiliki nilai sig. 0,329 > 0,05. Price to Earning Ratio memiliki nilai sig. 0,001 < 0,05. Return on Equity Â Ratio memiliki nilai sig. 0,006 < 0,05. Pada pengujian secara simultan diketahui nilai sig. 0,000 < 0,05. Dari hasil penelitian disimpulkan bahwa pada pengujian secara parsial diketahui bahwa Debt to Equity Ratio tidak berpengaruh terhadap return saham, variabelÂ Price to Earning Ratio dan Return on Equity Â Ratio masing â€“ masing berpengaruh signifikan terhadap return saham. Pada pengujian secara simultan diketahui bahwa Debt to Equity Ratio, Price to Earning Ratio, Return on Equity Â Ratio secara bersama â€“ sama mempunyai pengaruh yang signifikan terhadap return saham. Dalam penelitian ini, variabel Price to Earning Ratio yang berpengaruh dominan terhadap return saham.
Sustainable Development Goals Against Unfair Business Competition Practices in Electronic Environment in Jordanian Legislation – Comparative Study
Authors: Ahmad Alsharu , Enad Talafheh , Nashat Bani Hamad , Ali Ababneh , Khaled Khwaileh , Khaled Alamayrey , Fadel Khasswneh , Nidaa Jawad , Ziyad Bashabsheh , Tasnim Aldowery 
Published: August 2024

Objective: this study is to investigate to attempt to provide some legal assurance for fair and reasonable competition among business actors to sustainable development.

Theoretical Framework: In this topic, digital market (e-commerce) is, the market reality today for Jordanian businesses and customers, and unfair business competition in the digital market is a new phenomenon. Hence, in the Jordanian context, this study attempted to impose more rules in order to reduce the potentials for unfair competition.

Method: The study used the legal approach through used of the descriptive doctrinal approach by referring to laws, books, research and other references via the Internet. As for the comparative approach, such as referring to the law of the United Kingdom, French law and other laws to reach solutions to address unfair competition in e-commerce in Jordan.

Results and Discussion: The rules in Jordan are not adequate in imposing some obligations and in protecting against illegal competition between merchants. In this regard, this study recommended the Jordanian unfair competition law and trade secrets 2000 need some amendments to keep abreast with the advancements in electronic transactions and to keep in line with the Law of Electronic Information and Transactions.

Research Implication: The execution of e-commerce has challenged by several issues such as language, regulations, taxation, difficulties in recognizing actors, and countries’ legal differences, especially in Jordan.

Originality/ Value: This research is the originality and creativity of the researcher and has not published before. It is a new work, which distinguishes the research from previous studies.
PENGGUNAAN MEDIA QUIZIZZ DALAM PENERAPAN KOSAKATA BAHASA ARAB
Authors: Hilmy Baso 
Published: August 2024

Technological advances currently in the industry 4.0 era require educators to be more active and creative in choosing learning media. This research aims to describe the use of quizizz as an alternative media in applying Arabic vocabulary. This research was carried out using a qualitative descriptive approach through the literature study method. The research results show that quizizz is a very easy, effective and interesting medium to use in online-based Arabic language evaluation and learning activities. This application can be implemented directly or as an assignment. The features available in this application can be used for Arabic language evaluation and learning activities, such as applying Arabic vocabulary. This research contributes to the development of Arabic language learning media, especially in Madrasas and religious universities.
Perancangan Sistem Presensi Karyawan Guna Meningkatkan Kedisiplinan Pada PT. Kawasan Berikat Nusantara Jakarta Utara
Authors: Agatha Bayu Dwidja , Putra Mardi Yudhi , Priyadi Wiwit 
Published: August 2024

Presensi karyawan masih menjadi isu penting tentang kedisiplinan seorang karyawan dalam mengukur suksesnya sebuah perusahaan. Mekanisme sistem presensi karyawan pada PT. Kawasan Berikat Nusantara sudah menggunakan mesin fingerprint, menggunakan Whatsapp sebagai media informasi task management dan Microsoft office sebagai pencatatan. Namun dengan adanya sistem kerja WFH (Work From Home) pencatatan dan penyimpanan data presensi karyawan pada PT. Kawasan Berikat Nusantara menjadi terkendala seperti adanya manipulasi jam kerja, izin cuti karyawan harus mengambil form ke kantor dimana proses tersebut membutuhkan waktu lama. Penelitian ini bertujuan merancang sistem presensi bagi karyawan agar dapat melakukan presensi, pengajuan cuti, mengelola task management, sehingga dapat menjadi penilaian dan monitoring kinerja karyawan. Solusi untuk menangani permasalahan ini yakni dengan merancang sebuah sistem presensi agar membantu pimpinan dalam memonitoring presensi serta kinerja karyawan. Metode yang digunakan adalah eXtreme Programming, karena dapat menangani perubahan-perubahan requirement dari user saat proses pengembangan sistem berlangsung. Hasil dari sistem presensi adalah sistem aplikasi berbasis web presensi yang memiliki fitur presensi, pengajuan izin dan cuti dan task management. Selain itu, sistem aplikasi berbasis web ini membantu karyawan dengan sistem kerja WFH (Work From Home), mempermudah atasan dalam melakukan penilaian dan monitoring kinerja karyawan melalui task management yang pada akhirnya dapat meningkatkan kedisplinan karyawan.
Meningkatkan Hasil Belajar Siswa Melalui Media Jarimatika pada Materi Kelipatan Bilangan di Kelas IV SDN 140/II Talang Silungko Kecamatan Bathin II Pelayang Kabupaten Bungo
Authors: Afriastini Siti , Sungkowo  , Adilla Ulfa , Dewi Yurnalisma 
Published: August 2024

Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa kelas IV SDN 140/II Talang Silungko Kecamatan Bathin II Pelayang Kabupaten Bungo pada mata pelajaran Kelipatan Bilangan. Metode penelitian ini adalah penelitian tindakan kelas yang menggunakan model Kemmis and Taggart. Teknik pengumpulan data yang digunakan yaitu observasi, wawancara, tes dan dokumentasi. Hasil penelitian menunjukan bahwa penggunaan media jarimatika dapat meningkatkan hasil belajar siswa pada pembelajaran Kelipatan Bilangan di kelas IV SDN 140/II Talang Silungko Kecamatan Bathin II Pelayang Kabupaten Bungo. Hasil belajar siswa telah memenuhi indikator keberhasilan peneliti yaitu 60% pada masing-masing indikator hasil belajar. persentase hasil belajar siswa pada pra siklus adalah 31,81%. Pada siklus I sebesar 54,54%, dan pada siklus II mencapai 86,36%. Berdasarkan hasil analisis data, maka penerapan media jarimatika pada pembelajaran Kelipatan Bilangan dapat meningkatkan hasil belajar siswa kelas IV SDN 140/II Talang Silungko Kecamatan Bathin II Pelayang Kabupaten Bungo.
Improving Students’ Reading Comprehension On Persuasive Text Through Storytelling
Authors: Rotua Elfrida  , Sry Natalina Hutapea  
Published: August 2024

This research deals with the improving students’ reading comprehension achievement on persuasive text through storytelling. This research is aimed to find out the improvement of the students’ reading comprehension achievement on persuasive text if teaching by applying storytelling. The design of the research is conducted by using action research method. It was done through planning, action, observation, and reflection. The subject of this research is the 2013/2014 students of the Grade XI of SMA Swa Bina Karya Medan. This research applies quantitative and qualitative method. Quantitative data are taken from the students' reading comprehension test. Qualitative data are taken from diary notes, interview, and observation. The result of the research shows that there is improvement of students’ reading comprehension on persuasive text through storytelling.
PENGEMBANGAN MEDIA ANIMAL FLASH CARD SEBAGAI UPAYA MENINGKATKAN KEMAMPUAN KOSA KATA DAN PEMAHAMAN BAHASA ANAK USIA DINI DI RA ANNURIYAH BELIKANGET
Authors: Agus Fathoni Prasetyo  , Umi Rosidah  
Published: August 2024

Animal flash card yang digunakan di RA Annuriyah Belikanget adalah kartu bergambar hewan dengan keterangan nama hewan di bawahnya. Sedangkan yang dikembangkan oleh peneliti adalah kartu bergambar binatang dengan menggunakan 3 bahasa, yaitu bahasa Indonesia, bahasa Jawa dan Bahasa Inggris. Tujuan dari pengembanga ini adalah untuk mengenalkan dan memperkaya bahasa pada anak usia dini. Penilitian ini memberikan jawaban terhadap rumusan masalah (1) Bagaimana kevalidan media Animal flash card dalam meningkatkan kemampuan bahasa dan pemahaman kosa kata anak usia dini di RA Annuriyah Belikanget? (2) Bagaimana keefektifan media Animal flash card dalam meningkatkan kemampuan bahasa dan pemahaman kosa kata pada anak usia dini di RA Annuriyah Belikanget? (3) Bagaimana kepraktisan media Animal flash card? Jenis penelitian yang digunakan adalah research and developmen dengan menggunakan model pengembangan 4-D. Dari hasil penelitian dapat disimpulkan bahwa: (1) Berdasarkan data uji kevalidan, media animal flash card pada materi berbahasa memenuhi kategori sangat valid atau sangat layak. (2) Berdasarkan tingkat kepraktisan, media animal flash card yang dikembangkan diperoleh respon guru terhadap media yang dikembangkan memperoleh persentase 93,3%. (3) Berdasarkan keefektifan, media animal flash card dari perolehan data dan analisis data keefektifan produk pengembangan media animal flash card menunjukkan terjadinya peningkatan tinggi menurut perhitungan skor gain hasil nilai keaktifan akhir lebih tinggi dari pada nilai keaktifan awal.
PERPUTARAN KAS DAN PERPUTARAN PIUTANG TERHADAP LIKUIDITAS PERUSAHAAN
Authors: Mutiara Pipit , Aprilla Inka Aurana , Rufaidah Fathi 
Published: August 2024

Kurangnya kontrol atas tingkat likuiditas perusahaan menyebabkan kehilangan kepercayaan dan bantuan dari orang asing (kreditur), yang dapat menghambat kapasitasnya untuk tumbuh. Penelitian ini bertujuan untuk mengevaluasi hasil parsial dan simultan antara perputaran kas dan perputaran piutang pada likuiditas mengenai industri manufaktur sektor food and beverage tercatat di Bursa Efek Indonesia periode 2018-2021. Populasi yang dipakai 30 perusahaan, teknik yang dipakai purposive sampling maka sempel yang dipakai adalah 9 industri dengan jumlah data sebanyak 36. Teknik penelitian deskriptif dan verifikatif digunakan pendekataan kuantitatif, Analisis regresi linier berganda adalah teknik yang digunakan untuk analisis data. Uji asumsi klasik dan uji hipotesi. Riset membuktikan maka perputaran kas tiada berdampak pada likuiditas, secara parsial likuiditas secara signifikan dipengaruhi oleh perputaran piutang, secara simultan perputaran kas dan perputaran piutang perusahaan manufaktur di sektor food and beverage yang terdaftar di Bursa Efek Indonesia selama periode 2018–2021 berpengaruh signifikan terhadap likuiditasnya.