bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Space Group of Cesium Perbromate, CsBrO4
Authors: Rögner Peter , Schießl Ulrike , Range Klaus-Jürgen 
Published: March 2015

Abstract
The correct space group of cesium perbromate, CsBrO4, is I41/amd and not I41/a as previously reported. The compound is isostructural with α-CsReO4, the high-temperature modification of cesium perrhenate. By analogy with CsReO4 and CsIO4, a phase transformation to a low-tempera­ture modification is predicted for CsBrO4.
Ein Orthoperrhenat mit flächenverknüpften ReO6-Oktaedern: Hochdrucksynthese und Kristallstruktur von K3NaRe2O9 / An Orthoperrhenate with Face-Sharing ReO6 Octahedra: High-Pressure Synthesis and Crystal Structure of K3NaRe2O9
Authors: Range Klaus-Jürgen , Atzesdorfer Alexandra 
Published: March 2015

Abstract
The title compound was prepared by high-pressure reaction of rhenium metal with technical grade (i.e., Na containing) KO2 in a modified Belt-type apparatus (20 kbar, 1000 °C, 60 min, Au capsule). The amber-coloured crystals are very hygroscopic and decompose rapidly when exposed to air. K3NaRe2O9 crystallizes hexagonally, space group P63/mmc, with a = 6.012(1), c = 14.342(14) Å, c/a = 2.386 and Z = 2. The structure was refined to R = 0.031, Rw = 0.023 for 422 independent, absorption-corrected reflections with l > σ (I). K3NaRe2O9 is isostructural with 6H-BaTiO3, a perowskite variant, and contains Na and Re in octaedral coordination. Two ReO6 octahedra are face-sharing, thus creating a Re2O9 double octahedron with a Re-R e distance of 2.92 Å.
Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2
Authors: Wallace Heather A , Klebba Joseph E , Kusch Thomas , Rogers Gregory C , Bosco Giovanni 
Published: March 2015

Abstract
The spatial organization of the genome within the eukaryotic nucleus is a dynamic process that plays a central role in cellular processes such as gene expression, DNA replication, and chromosome segregation. Condensins are conserved multi-subunit protein complexes that contribute to chromosome organization by regulating chromosome compaction and homolog pairing. Previous work in our laboratory has shown that the Cap-H2 subunit of condensin II physically and genetically interacts with the Drosophila homolog of human MORF4-related gene on chromosome 15 (MRG15). Like Cap-H2, Mrg15 is required for interphase chromosome compaction and homolog pairing. However, the mechanism by which Mrg15 and Cap-H2 cooperate to maintain interphase chromatin organization remains unclear. Here, we show that Cap-H2 localizes to interband regions on polytene chromosomes and co-localizes with Mrg15 at regions of active transcription across the genome. We show that co-localization of Cap-H2 on polytene chromosomes is partially dependent on Mrg15. We have identified a binding motif within Cap-H2 that is essential for its interaction with Mrg15, and have found that mutation of this motif results in loss of localization of Cap-H2 on polytene chromosomes and results in partial suppression of Cap-H2-mediated compaction and homolog unpairing. Our data are consistent with a model in which Mrg15 acts as a loading factor to facilitate Cap-H2 binding to chromatin and mediate changes in chromatin organization.
Chromatin Mediation of a Transcriptional Memory Effect in Yeast
Authors: Paul Emily , Tirosh Itay , Lai William , Buck Michael J , Palumbo Michael J , Morse Randall H 
Published: March 2015

Abstract
Previous studies have described a transcriptional “memory effect,” whereby transcript levels of many Abf1-regulated genes in the budding yeast Saccharomyces cerevisiae are undiminished even after Abf1 has dissociated from its regulatory sites. Here we provide additional support for this effect and investigate its molecular basis. We show that the effect is observed in a distinct abf1 ts mutant from that used in earlier studies, demonstrating that it is robust, and use chromatin immunoprecipitation to show that Abf1 association is decreased similarly from memory effect and transcriptionally responsive genes at the restrictive temperature. We also demonstrate that the association of TATA-binding protein and Pol II decreases after the loss of Abf1 binding for transcriptionally responsive genes but not for memory effect genes. Examination of genome-wide nucleosome occupancy data reveals that although transcriptionally responsive genes exhibit increased nucleosome occupancy in abf1 ts yeast, the promoter regions of memory effect targets show no change in abf1 ts mutants, maintaining an open chromatin conformation even after Abf1 eviction. This contrasting behavior reflects different inherent propensity for nucleosome formation between the two classes, driven by the presence of A/T-rich sequences upstream of the Abf1 site in memory effect gene promoters. These sequence-based differences show conservation in closely related fungi and also correlate with different gene expression noise, suggesting a physiological basis for greater access to “memory effect” promoter regions. Thus, our results establish a conserved mechanism underlying a transcriptional memory effect whereby sequences surrounding Abf1 binding sequences affect local nucleosome occupancy following loss of Abf1 binding. Furthermore, these findings demonstrate that sequence-based differences in the propensity for nucleosome occupancy can influence the transcriptional response of genes to an altered regulatory signal.
Diversity of Maize Shoot Apical Meristem Architecture and Its Relationship to Plant Morphology
Authors: Thompson Addie M , Yu Jianming , Timmermans Marja C P , Schnable Patrick , Crants James E , Scanlon Michael J , Muehlbauer Gary J 
Published: March 2015

Abstract
The shoot apical meristem contains a pool of undifferentiated stem cells and controls initiation of all aerial plant organs. In maize (Zea mays), leaves are formed throughout vegetative development; on transition to floral development, the shoot meristem forms the tassel. Due to the regulated balance between stem cell maintenance and organogenesis, the structure and morphology of the shoot meristem are constrained during vegetative development. Previous work identified loci controlling meristem architecture in a recombinant inbred line population. The study presented here expanded on this by investigating shoot apical meristem morphology across a diverse set of maize inbred lines. Crosses of these lines to common parents showed varying phenotypic expression in the F1, with some form of heterosis occasionally observed. An investigation of meristematic growth throughout vegetative development in diverse lines linked the timing of reproductive transition to flowering time. Phenotypic correlations of meristem morphology with adult plant traits showed an association between the meristem and flowering time, leaf shape, and yield traits, revealing links between the control and architecture of undifferentiated and differentiated plant organs. Finally, quantitative trait loci mapping was utilized to map the genetic architecture of these meristem traits in two divergent populations. Control of meristem architecture was mainly population-specific, with 15 total unique loci mapped across the two populations with only one locus identified in both populations.
Finding a Missing Gene: EFG1 Regulates Morphogenesis in Candida tropicalis
Authors: Mancera Eugenio , Porman Allison M , Cuomo Christina A , Bennett Richard J , Johnson Alexander D 
Published: March 2015

Abstract
Fungi from the genus Candida are common members of the human microbiota; however, they are also important opportunistic pathogens in immunocompromised hosts. Several morphological transitions have been linked to the ability of these fungi to occupy the different ecological niches in the human body. The transcription factor Efg1 from the APSES family plays a central role in the transcription circuits underlying several of these morphological changes. In Candida albicans, for example, Efg1 is a central regulator of filamentation, biofilm formation, and white-opaque switching, processes associated with survival in the human host. Orthologs of Efg1 are present throughout the Candida clade but, surprisingly, the genome sequence of Candida tropicalis failed to uncover a gene coding for Efg1. One possibility was that the paralog of Efg1, Efh1, had assumed the function of Efg1 in C. tropicalis. However, we show that this gene has only a minor role in the morphological transitions mentioned above. Instead, we report here that C. tropicalis does have an ortholog of the EFG1 gene found in other Candida species. The gene is located in a different genomic position than EFG1 in C. albicans, in a region that contains a gap in the current genome assembly of C. tropicalis. We show that the newly identified C. tropicalis EFG1 gene regulates filamentation, biofilm formation, and white-opaque switching. Our results highlight the conserved role of Efg1 in controlling morphogenesis in Candida species and remind us that published genome sequences are drafts that require continuous curation and careful scrutiny.
Comorbidity of Physical and Mental Disorders in the Neurodevelopmental Genomics Cohort Study
Authors: Merikangas Kathleen R. , Calkins Monica E. , Burstein Marcy , He Jian-Ping , Chiavacci Rosetta , Lateef Tarannum , Ruparel Kosha , Gur Ruben C. , Lehner Thomas , Hakonarson Hakon , Gur Raquel E. 
Published: March 2015

OBJECTIVES:To examine patterns of associations between a broad range of mental and physical conditions by using a large, systematically obtained pediatric registry.METHODS:The sample included 9014 youth ages 8 to 21 years (4349 males and 4665 females; 3585 aged &lt;13 years, 3678 aged 13 to 18 years, and 1751 aged 19 to 21 years) from the Philadelphia Neurodevelopmental Cohort identified through pediatric clinics at the Children’s Hospital of Philadelphia health care network by the Center for Applied Genomics. Measures were as follows: physical condition based on electronic medical records and interview data on 42 physical conditions of 14 organ systems/specialties and mental disorders based on an abbreviated version of the structured Kiddie-Schedule for Affective Disorders and Schizophrenia psychiatric diagnostic interview.RESULTS:There was a direct association between the severity of the physical condition and most classes of mental disorders, as well as with functional impairment. Models adjusted for sociodemographic correlates, other physical and mental disorders, and false discovery and revealed broad patterns of associations between neurodevelopmental disorders with behavior disorders (odds ratio [OR]: 1.5; 95% confidence interval [CI]: 1.3–1.8; P &lt; .004) and attention-deficit/hyperactivity disorder (OR: 3.1; 95% CI: 2.7–3.6; P &lt; .0001), and neurologic/central nervous system conditions (OR: 1.3; 95% CI: 1.1–1.9; P &lt; .05) with mood disorders and attention-deficit/hyperactivity disorder (OR: 1.3; 95% CI: 1.1–1.5; P &lt; .001), and autoimmune/inflammatory conditions with mood disorders (OR: 1.4; 95% CI: 1.1–1.8, P &lt; .05).CONCLUSIONS:Findings show the strong overlap between physical and mental conditions and their impact on severity and functional impairment in youth. Specific patterns of comorbidity have important implications for etiology. Prospective tracking of cross-disorder morbidity will be important to establish more effective mechanisms for prevention and intervention.
Diversity and Inclusion Training in Pediatric Departments
Authors: Mendoza Fernando S. , Walker Leslie R. , Stoll Barbara J. , Fuentes-Afflick Elena , St Geme Joseph W. , Cheng Tina L. , Gonzalez del Rey Javier A. , Harris Christopher E. , Rimsza Mary E. , Li Jie , Sectish Theodore C. 
Published: March 2015

BACKGROUND AND OBJECTIVE:
The diversifying US population of children necessitates assessing the diversity of the pediatric academic workforce and its level of cultural competency training. Such data are essential for workforce and educational policies.

METHODS:
An 8-question survey was sent to 131 US pediatric chairs to assess plans for diversity, targeted groups, departmental diversity, diversity measures, perceived success in diversity, and presence and type of cultural competency training.

RESULTS:
In all, 49.6% of chairs responded, and three-quarters of them reported having a plan for diversity, which targeted racial; ethnic; gender; lesbian, gay, bisexual, and transgender; disabled; and social class groups. Of the residents, 75% were women, as compared with 54% of faculty and 26% of chairs. Racial and ethnic diversity was limited among trainees, faculty, and leaders; &lt;10% of each group was African American, Hispanic, or Native American. Asian Americans were more common among trainees (15%–33%) but were less common in faculty and leadership positions (0%–14%). Lesbian, gay, bisexual, and transgender physicians were represented in some groups. Measures of diversity included the number of trainees and faculty, promotion success, climate assessments, and exit interviews. Overall, 69% of chairs reported being successful in diversity efforts. A total of 90% reported cultural competency training for trainees, and 74% reported training for faculty and staff. Training in cultural competency included linguistic training, primarily in Spanish.

CONCLUSIONS:
Pipeline issues for minorities are ongoing challenges. Pediatric leadership needs more representation of racial and ethnic minorities, women, and LGBT. Suggestions for workforce and educational policies are made.
Parent-Reported Outcomes of a Shared Decision-Making Portal in Asthma: A Practice-Based RCT
Authors: Fiks Alexander G. , Mayne Stephanie L. , Karavite Dean J. , Suh Andrew , O’Hara Ryan , Localio A. Russell , Ross Michelle , Grundmeier Robert W. 
Published: March 2015

BACKGROUND:
Electronic health record (EHR)-linked patient portals are a promising approach to facilitate shared decision-making between families of children with chronic conditions and pediatricians. This study evaluated the feasibility, acceptability, and impact of MyAsthma, an EHR-linked patient portal supporting shared decision-making for pediatric asthma.

METHODS:
We conducted a 6-month randomized controlled trial of MyAsthma at 3 primary care practices. Families were randomized to MyAsthma, which tracks families’ asthma treatment concerns and goals, children’s asthma symptoms, medication side effects and adherence, and provides decision support, or to standard care. Outcomes included the feasibility and acceptability of MyAsthma for families, child health care utilization and asthma control, and the number of days of missed school (child) and work (parent). Descriptive statistics and longitudinal regression models assessed differences in outcomes between study arms.

RESULTS:
We enrolled 60 families, 30 in each study arm (mean age 8.3 years); 57% of parents in the intervention group used MyAsthma during at least 5 of the 6 study months. Parents of children with moderate to severe persistent asthma used the portal more than others; 92% were satisfied with MyAsthma. Parents reported that use improved their communication with the office, ability to manage asthma, and awareness of the importance of ongoing attention to treatment. Parents in the intervention group reported that children had a lower frequency of asthma flares and intervention parents missed fewer days of work due to asthma.

CONCLUSIONS:
Use of an EHR-linked asthma portal was feasible and acceptable to families and improved clinically meaningful outcomes.
Antidepressant Use During Pregnancy and Asthma in the Offspring
Authors: Liu Xiaoqin , Olsen Jørn , Pedersen Lars Henning , Agerbo Esben , Yuan Wei , Li Jiong 
Published: March 2015

BACKGROUND AND OBJECTIVES:
It has been suggested that maternal depression during pregnancy is associated with asthma in the offspring, but the role of medical treatment of depression is not known. Our goal was to examine whether prenatal antidepressant use increases the risk of asthma in the offspring.

METHODS:
A cohort study was performed among all live singletons born in Denmark between 1996 and 2007. Mothers who had a diagnosis of depressive disorder and/or who used antidepressants 1 year before or during the index pregnancy were identified. Using a Cox proportional hazards regression model, we estimated the hazard ratio (HR) for asthma in the offspring after antidepressant use during pregnancy.

RESULTS:
Of the 733 685 children identified, 84 683 had a diagnosis of asthma. A total of 21 371 children were exposed to prenatal maternal depression (ie, a diagnosis of depressive disorder or use of antidepressants 1 year before or during pregnancy). Prenatal maternal depression was associated with childhood asthma (HR: 1.25 [95% confidence interval (CI): 1.20–1.30]). Overall, 8895 children were exposed to antidepressants in utero. Compared with children born to mothers with prenatal depression and no antidepressant use during pregnancy, the HR for asthma after any antidepressant use during pregnancy was 1.00 (95% CI: 0.93–1.08). HRs after use of selective serotonin reuptake inhibitors only, newer antidepressants only, and older antidepressants only were 0.95 (95% CI: 0.88–1.03), 1.11 (95% CI: 0.89–1.39), and 1.26 (95% CI: 1.02–1.55), respectively.

CONCLUSIONS:
Antidepressant use during pregnancy generally did not increase the risk of asthma. Only use of older antidepressants was associated with an increased risk of asthma.
A eficácia gerencial aferida pelo alcance das metas estabelecidas no sistema de recompensa e sua relação com o empowerment psicológico
Authors: Do Nascimento Sabrina , Beuren Ilse Maria 
Published: March 2015

O estudo objetiva averiguar a eficácia gerencial aferida pelo alcance das metas estabelecidas no sistema de recompensa aos empregados e sua relação com o empowerment psicológico em uma empresa multinacional. A presença do empowerment psicológico se circunscreve nesta pesquisa nos quatro elementos do modelo de Spreitzer (1995): competência, impacto, autodeterminação e significado. Pesquisa descritiva com abordagem predominantemente qualitativa foi realizada em uma empresa de origem americana, estabelecida na região Sul do Brasil. Para a coleta dos dados, utilizaram-se dois tipos de instrumentos de pesquisa: a) um questionário adaptado de Spreitzer (1995), composto de 24 questões com escala likert de sete pontos, para identificar a percepção dos empregados da empresa sobre o empowerment psicológico; e b) três roteiros de entrevistas, aplicados, respectivamente, ao supervisor de recursos humanos, gerente financeiro-contábil e supervisor de importação e exportação, para aferir a eficácia gerencial nas dimensões (padrões de desempenho, comparação de pares e desempenho global) propostas por Spreitzer (1995). Os dados coletados por meio de questionário foram submetidos à análise estatística simples, média e desvio padrão; os coletados nos roteiros de entrevistas, à análise de conteúdo. Ainda, para apurar os indicadores de lucratividade e rentabilidade, coletaram-se dados nas demonstrações contábeis da empresa publicadas no site da Bolsa de Valores de Nova York (NYSE). Conclui-se, com base nos resultados da pesquisa, que o empowerment psicológico, segundo o modelo de Spreitzer (1995), está relacionado com a eficácia gerencial aferida pelo alcance das metas estabelecidas no sistema de recompensa aos empregados na empresa objeto de estudo.
Caso empresarial: La estrategia de crecimiento de Comercializadora Inducascos S.A.
Authors: Velásquez-Montoya Marcela , Robledo-Ardila Cristina , Aristizabal-Uribe Esteban 
Published: March 2015

Comercializadora Inducascos S.A. inició sus operaciones en 1998 en la ciudad de Medellín, Colombia, enfrentando dificultades de todo tipo, tales como escaso capital, infraestructura limitada y un número reducido de empleados. Además, su fundador habia enfrentado varias quiebras económicas. Esta comercializadora es ahora una empresa mediana para el sector local con un alto porcentaje de participación de mercado debido al volumen de cascos que fabrica y comercializa, a su amplio portafolio de productos y a su estructura comercial que le permiten atender todos los segmentos del mercado colombiano. El crecimiento de las ventas de motocicletas en Colombia, el boom de importaciones de motos chinas desde el 2005 y la evolución de la normativa concerniente al uso obligatorio del casco han contribuido a que los volúmenes de ventas de la empresa hayan crecido de manera exponencial desde su creación y a que exista una demanda constante del producto. Este caso describe la toma de decisiones del fundador Ramiro Agudelo, que se traduce en la estrategia de crecimiento e internacionalización de la empresa.
A fuzzy finite element algorithm based on response surface method for free vibration analysis of structure
Authors: Tuan Nguyen Hung , Huynh Le Xuan , Anh Pham Hoang 
Published: March 2015

This paper introduces an improved response surface-based fuzzy finite element analysis of structural dynamics. The free vibration of structure is established using superposition method, so that fuzzy displacement responses can be presented as functions of fuzzy mode shapes and fuzzy natural frequencies. Instead of direct determination of these fuzzy quantities by modal analysis which will involve the calculation of the whole finite element model, the paper proposes a felicitous approach to design the response surface as surrogate model for the problem. In the design of the surrogate model, complete quadratic polynomials are selected with all fuzzy variables are transformed to standardized fuzzy variables. This methodology allows accurate determination of the fuzzy dynamic outputs, which is the major issue in response surface based techniques. The effectiveness of the proposed fuzzy finite element algorithm is illustrated through a numerical analysis of a linear two-storey shear frame structure.
Data assimilation method in flood forecasting for Red river system using high performent computer
Authors: Don Nguyen Thanh , Que Nguyen Van , Hung Tran Quang , Phong Nguyen Hong 
Published: March 2015

Around the world, the data assimilation framework has been reported to be of great interest for weather forecasting, oceanography modeling and for shallow water flows particularly for flood model. For flood model this method is a power full tool to identify time-independent parameters (e.g. Manning coefficients and initial conditions) and time-dependent parameters (e.g. inflow). This paper demonstrates the efficiency of the method to identify time-dependent parameter: inflow discharge with a real complex case Red River. Firstly, we briefly discuss about current methods for determining flow rate which encompasses the new technologies, then present the ability to recover flow rate of this method. For the case of very long time series, a temporal strategy with time overlapping is suggested to decrease the amount of memory required. In addition, some different aspects of data assimilation are covered from this case.