bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Maximizers Estimate Their Decision Time: The Mediating Effect of Memory Reduction
Authors: Huang He , Li Hong 
Published: July 2024

ABSTRACTPrevious studies have divided people into maximizers and satisficers based on their tendency to seek the best in decision‐making. In the present research, we aim to unravel the time estimation process of maximizers in decision‐making through four studies. The results indicate that maximizers tend to underestimate the time spent in decision‐making, which is due to the difference in their memory reduction for decision‐related information compared to that of satisficers. Specifically, maximizers' memories of special information (rather than common information) become worse than those of satisficers, which leads to their underestimation of decision time. These findings provide a deeper understanding of how maximizers estimate their decision time, which offers important insights into how maximizers make their decisions. Overall, this research contributes to the literature by shedding new light on maximization from the perspective of memory.
A new application of avocado oil to enrich the biological activities of polycaprolactone membranes for tissue engineering
Authors: Yurtsever Merve Çapkın , Aydoğan Selin , İyigündoğdu Zeynep , Cömertpay Alican , Demir Didem , Ceylan Seda 
Published: July 2024

AbstractThe metabolites synthesized by plants to protect themselves serves as natural antimicrobial agents used in biomaterials. In this study, avocado oil (AO), was incorporated as a plant source and natural antimicrobial agent into polycaprolactone (PCL) membranes. The effects of varying AO ratios (25, 50, and 100 wt%.—PCL@25AO, PCL@50AO, PCL@100AO) on PCL membrane morphology, chemical structure, wettability, antimicrobial activity, and cell viabilities were investigated. It was demonstrated that the AO acts as a pore‐forming agent in solvent‐casted membranes. Young's modulus of the membranes varied between 602.68 and 31.92 MPa and more flexible membranes were obtained with increasing AO content. Inhibition zones of AO were recorded between 7.86 and 13.97 mm against clinically relevant microbial strains including bacteria, yeast, and fungi. Antimicrobial activity of AO was retained in PCL membranes at all ratios. Resazurin assay indicated that PCL@25AO membranes were cytocompatible with mouse fibroblast cells (L929 cell line) on day 6 showing 72.4% cell viability with respect to neat PCL membranes. Viability results were supported by scanning electron microscopy images and DAPI staining. The overall results of this study highlight the potential of PCL@25AO membranes as a biomaterial with antimicrobial properties, cytocompatibility, and mechanical strength suitable for various biomedical applications.
Developing and testing a Tool for Rapid Assessment of Sustainability in Organisations
Authors: Lozano Rodrigo , Barreiro‐Gen María 
Published: July 2024

AbstractAssessment and reporting has been recognised as one of the key drivers for sustainability in organisations; however, most organisations' reports fall short of sustainability guidelines and the available sustainability assessment and reporting (SAR) frameworks have been limited by several issues. The aim of this paper is to develop and test a rapid sustainability in organisations framework that includes all the sustainability dimensions and their interactions using a manageable number of indicators. A survey was developed to investigate the impacts and contribution of organisations to sustainability, where 224 full responses were obtained. The responses were analysed using descriptive analysis, Friedman tests, analyses of variance, ratio analyses, and correlations. The results show that organisations still address sustainability through compartmentalisation and skewed to the social dimension of sustainability. The results also show that the understanding of SAR in practice in organisations is more advanced regarding sustainability interrelations than the available frameworks and theoretical discourses. The ratio analyses provide a more complete understanding than a ranking analysis. Easier and faster SAR can help better address the dimensions of sustainability and their interrelations, as well as the positive and negative contributions, in order to avoid reinforcing limited and incomplete sustainability efforts. The proposed framework (Tool for Rapid Assessment of Sustainability in Organisations [TRASO]) can serve as a first step for organisations to detect strong and weak points in their sustainability efforts by providing a rapid, balanced and holistic assessment of sustainability issues, which can, in turn, help in the decision‐making process in becoming more sustainable.
Analysis of the clinical efficacy and safety of anti‐PD‐1 immune checkpoint inhibitors in locally advanced nasopharyngeal cancer
Authors: Shi Shuling , Li Bingyan , Zhou Pengcheng , Chen Linhui , Li Huizhen , Wang Yingyi , Deng Xiaoyu , Dang Qianqian , Wu Jingjing , Zha Boya , Li Peihong , Zheng Yingjuan , Yang Daoke 
Published: July 2024

AbstractObjectiveTo analyze the efficacy and adverse effects of anti‐PD‐1 immune checkpoint inhibitors aimed at nasopharyngeal carcinoma (NPC).MethodsDuring the first stage of the study, using 40 patients with stage III/IVa NPC treated with anti‐PD‐1 immune checkpoint inhibitors in combination with chemoradiotherapy as a first‐line treatment (observation group) and 70 patients with NPC treated with chemoradiotherapy alone (control group). In the second stage of the study, 88 patients with NPC treated with immune checkpoint inhibitors were grouped according to the number of lines of immunotherapy, the number of times, and the types of application.ResultsObservation of the short‐term effects in the first stage indicated that the objective response rate (ORR) of the observation group and the control group against primary foci of NPC was 75.0% versus 40.0%; the mortality rate of the observation group was much lower than that of the control group. The overall first‐line treatment evaluation of the observation vs. control groups were as follows: ORR (67.5% vs. 38.6%); median PFS (17.52 vs. 17.21 months); and median OS (18.68 vs. 18.14 months), respectively (p < 0.05). The second stage of the study had an ORR of 53.4%, and the efficacy of immunotherapy was related to staging, timing, and frequency.ConclusionAnti‐PD‐1 immune checkpoint inhibitors combined with chemoradiotherapy as the first‐line treatment for nasopharyngeal carcinoma may improve patient outcomes significantly. Timing, frequency, and the type of immunotherapy exerted an effect on the efficacy of immunotherapy. Adverse effects that occurred during treatment were tolerable and controllable.
Large acute epidural hematoma from head pin fixation fracture
Authors: da Silva Vinicius Trindade Gomes , Makarem Louise , dos Santos Silva Rhuann Pontes , Teixeira Manoel Jacobsen , Paiva Wellingson Silva 
Published: July 2024

Key Clinical MessageRegarding head immobilization practices in neurosurgery, secondary fixation fractures are rare, underscoring the importance of precise pin positioning and an adequate force in the three‐point clamp to achieve adequate fixation. Attention should be given to factors such as changes in bone metabolism.
Recent Advances in Multi‐Walled Carbon Nanotubes for High‐Efficient Solid‐State Hydrogen Storage: A Review
Authors: Abdulkadir Bashir Abubakar , Setiabudi Herma Dina 
Published: July 2024

AbstractThis review highlights the promising potential of multi‐walled carbon nanotubes (MWCNTs) for solid‐state hydrogen storage due to their high surface area, low mass density, and chemical stability. Recent advances in doping and functionalization of MWCNTs have demonstrated enhanced hydrogen adsorption capacities that are closer to the United States Department of Energy targets. Transition metal atom doping has been shown to significantly improve hydrogen binding through spillover mechanisms. Additionally, metal doping of MWCNTs exhibited impressive gravimetric and volumetric hydrogen storage capacities. These developments represent a crucial step toward realizing safe, efficient, and cost‐effective solid‐state hydrogen storage solutions enabled by tailored MWCNTs for clean energy applications. Hence, this review aims to summarize the findings on the use of MWCNTs for hydrogen storage, where challenges are discussed and recommendations are provided.
Carbon Dots in Photodynamic Therapy: The Role of Dopant and Solvent on Optical and Photo‐Responsive Properties
Authors: Wibowo Agung , Jahir Khan Mohd , Sansanaphongpricha Kanokwan , Khemthong Pongtanawat , Laosiripojana Navadol , Yu Yu‐Sheng , Wu Kevin C.‐W. , Sakdaronnarong Chularat 
Published: July 2024

AbstractCarbon dots (CDs) are novel carbon‐based luminescent materials with wide‐ranging applications in biosensing, bioimaging, drug transportation, optical devices, and beyond. Their advantageous attributes, including biocompatibility, biodegradability, antioxidant activity, photostability, small particle size (<10 nm), and strong light absorption and excitation across a broad range of wavelengths, making them promising candidates in the field of photodynamic therapy (PDT) as photosensitizers (PSs). Further enhancements in functionality are imperative to enhance the effectiveness of CDs in PDT applications, notwithstanding their inherent benefits. Recently, doping agents and solvents have been demonstrated to improve CDs’ optical properties, solubility, cytotoxicity, and organelle targeting efficiency. These improvements result from modifications to the CDs’ carbon skeleton matrices, functional groups on the surface state, and chemical structures. This review discusses the modification of CDs with heteroatom dopants, dye dopants, and solvents to improve their physicochemical and optical properties for PDT applications. The correlations between the surface chemistry, functional groups, the structure of the CDs, and their optical characteristics toward quantum yield, redshift feature, and reactive oxygen species (ROS) generation, have also been discussed. Finally, the progressive trends for the use of CDs in PDT applications are also addressed in this review.
Color analysis of ancient Egyptian paintings and its applications in modern digital visualization
Authors: Zeng Qiaoling 
Published: July 2024

AbstractThis study aims to identify the color preferences of ancient Egyptian paintings and their cultural and historical reasons through color analysis, and consequently introduce a color collection of ancient Egyptian painting colors for color matching of modern digital images. A total of 134 original and 168 replica/repair painting samples were selected from the digital repositories of various authoritative museum collections, focusing on painting patterns formed on object surfaces using coloring agents. The collected samples, spanning from the Ancient Kingdom of Egypt to the Greco‐Roman period, encompass distinct types of ancient Egyptian paintings. The diversity and chronological distribution of these samples suggest that the color use in ancient Egyptian paintings is closely linked to the burial culture, coffin decoration, religious beliefs, and policy changes. Color analysis of the collected samples using the natural color system revealed that the predominant colors in ancient Egyptian paintings tend to be in the red and yellow spectrum, while the blue, green, and purple spectrum is relatively less prominent. This can be attributed to the historical development of colors, the scarcity of mineral resources, and the symbolic significance of colors in ancient Egyptian culture. Finally, a collection of ancient Egyptian painting colors was selected from extracted colors based on color differences to reflect the color characteristics of ancient Egyptian paintings. Furthermore, the construction method of color palettes with different thematic images and the practical application of these palettes in digital patterns using the proposed color collection were demonstrated to offer a reference for designers.
Novel insights into the pathological features of COPD: Focus on oxidative stress and mitophagy
Authors: Gao Jiameng , Shen Yao , Chen Zhihong 
Published: July 2024

AbstractChronic airway obstructive pulmonary disease (COPD) is a preventable and curable disease characterised by persistent airflow limitation. It is characterised by chronic bronchitis and/or emphysema, and its aetiology is related to various factors such as smoking and infectious factors, and so forth. The pathogenesis is complex and prone to frequent exacerbations, and the prognosis of acute exacerbations of COPD is often poor. As a crucial component of the innate immune system, lung macrophages significantly influence the onset and progression of COPD. When macrophage mitochondria become dysfunctional, many macrophage functions (e.g., phagocytosis, cytokine secretion, chemotaxis, etc.) change. The aim of this paper is to describe the three major pathological features of COPD (oxidative stress imbalance, macrophage polarisation and mitochondrial membrane potential [MMP] production and mitochondrial autophagy), to describe in detail the mechanism of mitochondrial autophagy pathway and its association with oxidative stress and macrophage polarisation and to emphasise the role of macrophage mitochondrial reactive oxygen species (mROS) in COPD, with the aim of providing ideas and directions for subsequent studies.
Unveiling the potential of karst vadose deposits in constraining Quaternary tectonic subsidence
Authors: Ballesteros Daniel , Pérez‐Mejías Carlos , Moreno Diego , Moreno‐Sánchez Marcos , Reyes‐Carmona Cristina , Alfonso‐Jorde David , Azañón José Miguel , Booth‐Rea Guillermo , Torre Davide , Jerez‐Longres Paula Sofía , Pérez‐Peña Vicente , González‐Ramón Antonio , Cheng Hai , Galve Jorge Pedro , Ruano Patricia 
Published: July 2024

AbstractIn carbonate coastlines, karst studies have traditionally focused on reconstructing Quaternary coastal uplift and sea level oscillations. However, their potential for investigating coastal subsidence remains unexplored in regions with limited sedimentary records and scientific monitoring. In line with this, our study delved into the utility of karst research for deciphering the Quaternary evolution of the Granada coast in southern Spain—a shoreline marked by a conspicuous scarcity of records and information regarding recent tectonic movements. The current labelling data and the absence of evidence for uplift led to the hypothesis that the Granada coast may be susceptible to subsidence, though this conjecture remained unconfirmed. While submerged marine terraces were clearly identified, they were previously interpreted as consequences of sea‐level oscillations. Our multidisciplinary approach integrated karst vadose features, biostratigraphy, and the dating of 22 speleothems to address the potential uplifting or subsiding dynamics of the Granada coast. The findings indicated that the Granada coast experienced emersion between 3.5/2.4 Ma and 650 ka ago. Notably, this uplift predated similar occurrences in neighbouring coastal regions to the W and E, which occurred within the last 200–180 ka. These disparities in timing cannot be solely attributed to sea‐level fluctuations, suggesting the involvement of the tectonic activity during the Quaternary. The tectonic likely led to the emergence of the Granada coast and its karstification, followed by subsidence. Furthermore, we identified the extensional faults that caused the coastal subsidence, previously documented in studies conducted in nearby regions. However, until now, their specific impact on the Granada coast had not been comprehensively stated. In summary, our research introduces a novel application of classical karst investigations in the understanding coastal subsidence and the extensional active tectonic. By comparing vadose cave ages with established chronologies in adjacent coastal areas, this approach sheds light on the complex tectonic evolution of coastal regions.
Advancing head and neck cancer management: Unveiling the diagnostic and therapeutic potentials of molecular profiling
Authors: Baral Binav , Suleiman Riham , Fazer‐Posorske Casey A. , Ma Daniel J. , McGarrah Patrick W. , Thome Stephan D. , Molina Julian R. , Price Katharine A. , Halfdanarson Thorvardur R. , Fuentes Harry E. 
Published: July 2024

AbstractBackgroundHead and neck cancers (HNC) present diagnostic challenges due to multifocal disease manifestations, posing difficulties in distinguishing between metastatic disease and second primary malignancies (SPM). This complexity underscores the need for advanced diagnostic approaches. Emerging technologies, such as next‐generation sequencing (NGS) and molecular classifier assays, show promise in providing precise insights into the diverse etiologies of HNC.MethodIn this article, we employed NGS and molecular classifier assays to delve into three distinct clinical cases. The objective was to showcase the instrumental role of these technologies in facilitating accurate diagnoses and differentiating between metastatic disease and SPM in HNC cases.ResultsThe results of this series highlight the effectiveness of NGS and molecular classifier assays in enhancing diagnostic accuracy for HNC and contributing to the precise differentiation of disease etiologies. The utilization of these advanced technologies proved instrumental in avoiding unnecessary interventions and paved the way for more targeted and effective treatment strategies.ConclusionOur findings underscore the necessity of incorporating advanced molecular testing technologies into the diagnostic and therapeutic approaches for HNC, thereby championing a more nuanced and effective approach to managing these complex cases.
Response and outcome of patients with melanoma skin metastases and immune checkpoint inhibition
Authors: Forschner Andrea , Nanz Lena , Maczey‐Leber Yves , Amaral Teresa , Flatz Lukas , Leiter Ulrike 
Published: July 2024

AbstractIt is known, that different metastatic organ systems respond differently to immune checkpoint inhibitors (ICIs). In this study, we aimed to investigate the extent to which skin/subcutaneous metastases respond to ICI or targeted therapies (TTs) and whether the response rate differs from that of distant metastases in the same patient. Patients with melanoma diagnosed between January 2021 and September 2023 with at least one skin/subcutaneous metastasis who had received therapy with ICI or TT in an advanced setting were included in the analysis. Best overall response (BOR) was classified according to the revised response evaluation criteria in solid tumors (RECIST). The BOR of skin metastases and visceral metastases to ICI and TT was compared using the chi‐square test. Skin metastases treated with ICI a first‐line setting showed an overall response rate (ORR) of 44.1%. In contrast, visceral metastases had a higher ORR of 51.1%. However, the difference was not statistically significant (p = .77). Regarding TT, the ORR for skin metastases was 57.1%, compared to 38.5% for visceral metastases (p = .59). Interestingly, the ORR for skin/subcutaneous metastases was notably lower with ICI compared to visceral metastases, in contrast to patients who underwent TT. Skin metastases showed a poorer response to ICI than visceral metastases. Therefore, careful monitoring is recommended to detect non‐response early in patients with skin metastases as skin metastases may have a worse response than TT. A larger cohort is needed for a comprehensive analysis and confirmation of our results.
Isoflurane preconditioning attenuates OGD/R‐induced cardiomyocyte cytotoxicity by regulating the miR‐210/BNIP3 axis
Authors: Zhang Dongbo , Wu Qiaoling , Liu Feifei , Shen Tu , Dai Siqi 
Published: July 2024

AbstractIsoflurane, a commonly used inhaled anesthetic, has been found to have a cardioprotective effect. However, the precise mechanisms have not been fully elucidated. Here, we found that isoflurane preconditioning enhanced OGD/R‐induced upregulation of miR‐210, a hypoxia‐responsive miRNA, in AC16 human myocardial cells. To further test the roles of miR‐210 in regulating the effects of isoflurane preconditioning on OGD/R‐induced cardiomyocyte injury, AC16 cells were transfected with anti‐miR‐210 or control anti‐miRNA. Results showed that isoflurane preconditioning attenuated OGD/R‐induced cardiomyocyte cytotoxicity (as assessed by cell viability, LDH and CK‐MB levels), which could be reversed by anti‐miR‐210. Isoflurane preconditioning also prevented OGD/R‐induced increase in apoptotic rate, caspase‐3 and caspase‐9 activities, and Bax level and decrease in Bcl‐2 expression level, while anti‐miR‐210 blocked these effects. We also found that anti‐miR‐210 prevented the inhibitory effects of isoflurane preconditioning on OGD/R‐induced decrease in adenosine triphosphate content; mitochondrial volume; citrate synthase activity; complex I, II, and IV activities; and p‐DRP1 and MFN2 expression. Besides, the expression of BNIP3, a reported direct target of miR‐210, was significantly decreased under hypoxia condition and could be regulated by isoflurane preconditioning. In addition, BNIP3 knockdown attenuated the effects of miR‐210 silencing on the cytoprotection of isoflurane preconditioning. These findings suggested that isoflurane preconditioning exerted protective effects against OGD/R‐induced cardiac cytotoxicity by regulating the miR‐210/BNIP3 axis.
Label‐free assessment of the transformation zone using multispectral diffuse optical imaging toward early detection of cervical cancer
Authors: Karthika J. , Anantharaju Arpitha , Koodi Dhanush , Pandya Hardik J. , Pal Uttam M. 
Published: July 2024

AbstractThe assessment of the transformation zone is a critical step toward diagnosis of cervical cancer. This work involves the development of a portable, label‐free transvaginal multispectral diffuse optical imaging (MDOI) imaging probe to estimate the transformation zone. The images were acquired from N = 5 (N = 1 normal, N = 2 premalignant, and N = 2 malignant) patients. Key parameters such as spectral contrast ratio (ρ) at 545 and 450 nm were higher in premalignant (0.29, 0.25 for 450 nm and 0.30, 0.17 for 545 nm) as compared to the normal patients (0.13 and 0.14 for 450 and 545 nm, respectively). The threshold for the spectral intensity ratio R610/R450 and R610/R545 can also be used as a marker to correlate with the new and original squamous columnar junction (SCJ), respectively. The pilot study highlights the use of new markers such as spectral contrast ratio (ρ) and spectral intensity ratio (R610/R450 and R610/R545) images.