bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of early pathogenesis in the SOD1G93A mouse model of ALS: part II, results and discussion
Authors: Vinsant Sharon , Mansfield Carol , Jimenez‐Moreno Ramon , Moore Victoria Del Gaizo , Yoshikawa Masaaki , Hampton Thomas G. , Prevette David , Caress James , Oppenheim Ronald W. , Milligan Carol 
Published: June 2013

AbstractPathological events are well characterized in amyotrophic lateral sclerosis (ALS) mouse models, but review of the literature fails to identify a specific initiating event that precipitates disease pathology. There is now growing consensus in the field that axon and synapses are first cellular sites of degeneration, but controversy exists over whether axon and synapse loss is initiated autonomously at those sites or by pathology in the cell body, in nonneuronal cells or even in nonmotoneurons (MNs). Previous studies have identified pathological events in the mutant superoxide dismutase 1 (SOD1) models involving spinal cord, peripheral axons, neuromuscular junctions (NMJs), or muscle; however, few studies have systematically examined pathogenesis at multiple sites in the same study. We have performed ultrastructural examination of both central and peripheral components of the neuromuscular system in the SOD1G93A mouse model of ALS. Twenty percent of MNs undergo degeneration by P60, but NMJ innervation in fast fatigable muscles is reduced by 40% by P30. Gait alterations and muscle weakness were also found at P30. There was no change in axonal transport prior to initial NMJ denervation. Mitochondrial morphological changes are observed at P7 and become more prominent with disease progression. At P30 there was a significant decrease in excitatory axo‐dendritic and axo‐somatic synapses with an increase in C‐type axo‐somatic synapses. Our study examined early pathology in both peripheral and central neuromuscular system. The muscle denervation is associated with functional motor deficits and begins during the first postnatal month in SOD1G93A mice. Physiological dysfunction and pathology in the mitochondria of synapses and MN soma and dendrites occur, and disease onset in these animals begins more than 2 months earlier than originally thought. This information may be valuable for designing preclinical trials that are more likely to impact disease onset and progression.
The halo model of origin images: Conceptualisation and initial empirical test
Authors: Josiassen Alexander , Lukas Bryan A. , Whitwell Gregory J. , Assaf A. George 
Published: June 2013

ABSTRACTNational origin has gained importance as a marketing tool for practitioners to sell their goods and services. However, because origin‐image research has been troubled by several fundamental limitations, academia has become sceptical of the current status and strategic implications of the concept. The aim of this paper was threefold, namely, to provide a state‐of‐the‐art review of origin‐image research in marketing, develop and empirically test a new origin‐image model and, present the implications of the study. Copyright © 2013 John Wiley & Sons, Ltd.
Second‐versus first‐generation “Limus”‐eluting stents in diabetic patients with coronary artery disease: A randomized comparison in setting of ISAR‐TEST‐4 trial
Authors: Kufner Sebastian , Byrne Robert A. , Mehilli Julinda , Massberg Steffen , Birkmeier Katrin A. , Schulz Stefanie , Pache Jürgen , Schömig Albert , Kastrati Adnan 
Published: June 2013

BackgroundPatients with diabetes mellitus remain at higher risk for adverse events following percutaneous coronary intervention and the identification of the optimum drug eluting stents (DES) in these patients is of high clinical relevance. We compared effectiveness of everolimus‐eluting stents (EES; Xience) versus sirolimus‐eluting stents (SES; Cypher) in patients with diabetes mellitus enrolled in the Intracoronary Stenting and Angiographic Results: Test Efficacy of 3 Limus‐Eluting Stents (ISAR‐TEST‐4) trial.MethodsIn the setting of the ISAR‐TEST‐4 trial, 1304 patients with broad inclusion criteria were randomized to treatment with EES or SES. The focus of the present analysis is on a cohort of 377 patients with diabetes mellitus assigned to receive EES (n = 184) or SES (n = 193). The primary endpoint was the composite of cardiac death, myocardial infarction (MI) related to the target vessel, or target lesion revascularization (TLR) at 3‐year follow‐up. Secondary endpoints were parameters of angiographic and clinical restenosis (in‐stent late lumen loss, binary restenosis, and TLR), all‐cause mortality and definite/probable stent thrombosis.ResultsEES was comparable to SES concerning the incidence of the primary endpoint (21% vs. 24%, respectively; relative risk = 0.87; 95% CI, 0.57–1.34; P = 0.53). Concerning the secondary endpoint, TLR at 3 years with EES versus SES stents was not statistically different (14.7% vs. 16.6%, respectively; relative risk = 0.85; 95% CI, 0.51–1.43; P = 0.55). In terms of angiographic outcomes patients treated with EES as compared to SES had significantly lower late lumen loss (0.22 ± 0.46 mm vs. 0.44 ± 0.66 mm, respectively; P < 0.001) and binary restenosis (8.4% vs. 17%, respectively; P = 0.02) at 6‐ to 8‐month angiographic follow‐up. EES was comparable to SES concerning the incidence of all‐cause death (10% vs. 16%, respectively; relative risk = 0.66; 95% CI, 0.37–1.18; P = 0.16) and stent thrombosis (1.1% vs. 3.1%, respectively; P = 0.19).ConclusionsIn patients with diabetes mellitus enrolled in a real‐world randomized control trial, EES is comparable to SES in terms of clinical efficacy and safety out to 3 years; angiographic markers of antirestenotic efficacy favored EES. © 2013 Wiley Periodicals, Inc.
Synthesis of Multivalent Carbohydrate‐Centered Glycoclusters as Nanomolar Ligands of the Bacterial Lectin LecA from Pseudomonas aeruginosa
Authors: Gening Marina L. , Titov Denis V. , Cecioni Samy , Audfray Aymeric , Gerbst Alexey G. , Tsvetkov Yury E. , Krylov Vadim B. , Imberty Anne , Nifantiev Nikolay E. , Vidal Sébastien 
Published: June 2013

AbstractA family of fifteen glycoclusters based on a cyclic oligo‐(1→6)‐β‐D‐glucosamine core has been designed as potential inhibitors of the bacterial lectin LecA with various valencies (from 2 to 4) and linkers. Evaluation of their binding properties towards LecA has been performed by a combination of hemagglutination inhibition assays (HIA), enzyme‐linked lectin assays (ELLA), and isothermal titration microcalorimetry (ITC). Divalent ligands displayed dissociation constants in the sub‐micromolar range and tetravalent ligands displayed low nanomolar affinities for this lectin. The influence of the linker could also be demonstrated; aromatic moieties are the best scaffolds for binding to the lectin. The affinities observed in vitro were then correlated with molecular models to rationalize the possible binding modes of these glycoclusters with the bacterial lectin.
Effect of bubbles and additives on friction factor in pipeline flow
Authors: Baghaei Pouria , Pal Rajinder 
Published: June 2013

AbstractThis work investigated drag reduction in turbulent flow of water using air bubbles and other additives. The first phase of the experimental program dealt with the effects of small air bubbles on wall shear stress and friction factor. The friction factor versus Reynolds number data exhibited different trends at low and high Reynolds numbers. At high Reynolds number, the two‐phase mixture behaved as a pseudo‐homogeneous system and the friction factor followed the single‐phase behaviour. At low Reynolds number, the observed friction factor was significantly higher than that of single‐phase fluids. The observed trends were interpreted in terms of the average bubble sizes predicted from a well‐known empirical equation. The second phase of the experimental program investigated the effects of additive/air‐bubble combinations on drag reduction in water flow where the additives used were frother and polymer. The addition of frother made the flow more homogeneous and the mixture followed the single‐phase behaviour more closely. In the absence of polymer, the injection of air bubbles generally increased the wall shear stress and friction factor compared to single‐phase flow, especially at low Reynolds number. However, the addition of polymer to two‐phase water/bubbles mixture induced drag reduction up to as high as 60%. The friction factor data for polymer‐solution/bubbles combination followed the polymer‐solution line, regardless of the presence of frother.
Systematic Error Compensation for Airborne Gravimetry
Authors: Zhong‐Miao SUN , Zhen‐He ZHAI , Yun XIAO , Ying‐Chun LI 
Published: June 2013

AbstractThe systematic error sources for airborne gravimetry are analyzed in detail using the basic mathematical model. The sources can be classified into three types: the first is the observation errors in the parking apron gravity values and the base reading of the airborne gravimeter, the second is the calibration errors of cross‐coupling correction, beam scale factor and the scale value, and the third is the modeling errors in the horizontal acceleration correction. The magnitudes of the various systematic errors are discussed and the related compensation methods are proposed. It is indicated that the modeling error of the horizontal acceleration correction (HAC) is one of the largest errors. Analysis of real data demonstrates that the systematic bias between airborne gravity and the ground (or sea) reference value in the Datong, Harbin and Bohai areas are all less than 1×10−5 m·s−2 after compensating the various systematic errors especially the modeling errors of horizontal acceleration correction.
Magnetic Properties of Sediments and Their Response to Environmental Changes During the Holocene in the Fuzhou Basin, Fujian, China
Authors: Zhi‐Hua SU , Xiao‐Qiang YANG , Jie YANG , Zhuo ZHENG , Yuan‐Fu YUE , Jian‐Hua WANG 
Published: June 2013

AbstractThe Fuzhou basin is an ideal place for high‐resolution paleoclimate study, because it lies in the coastal zone and its sediments contain wealth information on the interaction between ocean and land during the Holocene. In this paper, rock magnetism, environmental magnetism and paleomagnetism features of core FZ5 sediments in the Fuzhou basin were studied to reveal the response of magnetic properties to terrigenous input, sea‐level change and diagenesis. Studies of rock magnetism show that ferrimagnetic minerals with low coercivity are dominant minerals, while the types of magnetic minerals vary at different stages of environmental variation. Magnetite, siderite and some amounts of Fe‐sulphides are the main contributors to magnetic properties in the transgression environment during the Early and Middle Holocene (9∼3 cal. ka BP), although sulphidation dissolved fine‐grained magnetite to form greigite and pyrite. However, sulphidation did not completely eliminate the natural remanence carried by magnetite and the dominant controls of the terrestrial detritus input and sea‐level fluctuations to magnetic properties at this stage. During the late Holocene (3 cal. ka BP), magnetite was still partly dissolved to greigite due to the earlier reduction in the terrestrial oxidizing environment, but further transformation was restrained by the oxidation then. Strong oxidation process formed the high coercivity minerals and disturbed the natural remanence. During the deposition process, the six strong ancient oxide interfaces occurred at ∼8.2, ∼7.7, ∼7.5, ∼2.7, ∼1.5, and ∼0.5 cal. ka BP, respectively, which reflect the unusually dry or humid climate events in the Fuzhou basin.
Aeromagnetic Total Field Gridding Enhancement with Consideration of Variations in Horizontal Gradients
Authors: Ru‐Kuan XIE , Ping WANG , Hua GUO , Shu‐Ling DUAN , Hao‐Jun LIU , Jin‐Long WANG 
Published: June 2013

AbstractMeasured aeromagnetic lateral horizontal gradients reflect the magnetic field gradients perpendicular to survey lines and contain more magnetic field information between survey lines. Based on the Hardwick method and Akima interpolation, we used aeromagnetic lateral horizontal gradient and total field data to construct pseudo‐survey lines and study bi‐directional line gridding, and finally realized aeromagnetic total field gridding enhancement with consideration of variations in horizontal gradients. We also employed the effective filter method to remove level noise in gridding results. Processing results on theoretical models and real data show that this method can highlight magnetic anomaly details between survey lines, delineate linear structures or trends of magnetic units, and improve the accuracy and resolution of grid maps.
Acoustic Prestack Reverse Time Migration Using the Adaptive High‐Order Finite‐Difference Method in the Time‐Space Domain
Authors: Hong‐Yong YAN , Yang LIU 
Published: June 2013

Abstract:At present, prestack reverse time migration (RTM) is the most accurate method for seismic imaging in theory. One of its key steps is wavefield extrapolation. The essence of wavefield extrapolation is to solve the wave equation. Thus solving the wave equation fast yet accurately is very important. In this paper, we use a time‐space domain dispersion‐relation‐based finite‐difference (FD) method to solve the acoustic wave equation, then analyze the dispersion and stability of the numerical solution, perform the numerical modeling, and compare the results with the conventional FD method. The results of analysis and numerical modeling demonstrate the time‐space domain FD method has better accuracy and stability than the conventional method under the same discretization. We adopt the time‐space domain high‐order FD method to solve the acoustic wave equation in the process of wavefield extrapolation, then use the normalized cross‐correlation imaging condition to obtain imaging in RTM. The results of synthetic data processing show that the imaging accuracy has enhanced. Meanwhile, in the process of wavefield extrapolation, we adopt adaptive variable‐length spatial operators to compute spatial derivatives and thus to decrease computing cost significantly without reducing the accuracy of numerical modeling and imaging.
Association Between C‐Reactive Protein and Atrial Fibrillation Recurrence After Catheter Ablation: A Meta‐analysis
Authors: Jiang Zhouqin , Dai Limeng , Song Zhiyuan , Li Huakang , Shu Maoqin 
Published: June 2013

AbstractBackgroundAtrial fibrillation (AF) is associated with inflammation. Increased serum C‐reactive protein (CRP) levels are important representatives of an inflammatory state of AF. A variety of studies have evaluated whether increased CRP levels have an association with AF recurrence after catheter ablation. However, the results remain inconsistent, therefore, this meta‐analysis was conducted to offer suggestions.HypothesisIncreased baseline CRP have an association with AF recurrence after catheter ablation.MethodsElectronic databases including PubMed, Embase, Medline, ISI Web of Knowledge, and ScienceDirect were searched until December 31, 2012 for any CRP‐associated studies. Overall and subgroup analyses were performed. Standardized mean difference (SMD) and 95% confidence interval (CI) were used to evaluate the associations between CRP levels and postablation AF recurrence. Statistical analysis was performed with Review Manager 5.2 and Stata 11.0.ResultsSeven available studies were identified, which included 526 patients (179 recurrence vs 347 no recurrence). Overall, increased baseline CRP levels had significant positive association with postablation AF recurrence. The SMD in the CRP levels was 0.65 units (95% CI: 0.30‐0.99), and the z‐score for overall effect was 3.70 (P = 0.0002). The heterogeneity test showed that there were moderate differences between individual studies (P = 0.006, I2 = 67%). Metaregression revealed that different sample sizes of studies possibly accounted for the heterogeneity. Positive associations were also found in subgroup analyses based on sample size. When stratifying for ethnicity, similarly significant associations were found in both European (Caucasian) and Asian populations.ConclusionsInvestigations demonstrate that baseline CRP levels are greater in patients with postablation AF recurrence. Further studies with larger sample size and delicate design for CRP should be conducted.
A Web 2.0‐based science gateway for massive remote sensing image processing
Authors: Miao Yanhua , Wang Lizhe , Liu Dingsheng , Ma Yan , Zhang Wanfeng , Chen Lajiao 
Published: June 2013

SummaryWith the incessant expansion of applications and the frequent update of the software, Science Gateway for Massive Remote Sensing Image Processing (SGMRSIP), developed by client/server model or traditional browser/server model, has received more and more challenges. Fortunately, the Web 2.0 technologies, proposed in recent years, bring us a new user experience (UE) that has a fast response speed and a good interface. In particular, the remote sensing image can be processed smoothly in the absence of client software by Web 2.0 technologies. Hence, a Web 2.0‐based browser/server model is designed for SGMRSIP to enhance the UE in this paper. Firstly, functions of a parallel remote sensing image processing portal, based on high performance cluster and client/server model, are summarized. And then, a Web 2.0‐based interaction model is built, and all these functions are accomplished again on the basis of this model. Finally, the Web 2.0‐based Science Gateway is achieved. In addition, we design different workflows for different satellite data, and all the processing tasks are finished successfully to verify the feasibility of this Science Gateway. The experimental results showed that the software scalability and interaction were improved and a better UE was achieved, compared with the existing SGMRSIP. Copyright © 2013 John Wiley & Sons, Ltd.
A His‐Tagged Melanocarpus albomyces Laccase and its Electrochemistry upon Immobilisation on NTA‐Modified Electrodes and in Conducting Polymer Films
Authors: Sosna Maciej , Boer Harry , Bartlett Philip N. 
Published: June 2013

AbstractThe article describes the construction, immobilisation and electrochemistry of histidine tagged laccase from Melanocarpus albomyces. A facile method of functionalisation of glassy carbon electrodes with nitrilotriacetic acid (NTA) using diazonium grafting and solid state chemistry is described. NTA‐modified electrodes are shown to bind laccase which reduces oxygen at neutral pH in the presence of soluble redox mediator. Laccase‐modified electrodes are also prepared by enzyme immobilisation within poly(aniline)/poly(vinylsulfonate) films. The polymer is found to efficiently retain the enzyme as well as provide direct electrical contact between the electrode and the enzyme active centre. Cyclic voltammetry reveals the direct electron transfer to the enzyme is dependent on the redox state of the polymer film.
Molecular Imprinting of Tri‐O‐Acetyladenosine for the Synthetic Imitation of an ATP‐Binding Cleft in Protein Kinases
Authors: Lakka Achillia , Tsakalof Andreas 
Published: June 2013

AbstractA number of diseases, including cancer, diabetes, and inflammation, are linked to deregulation of cell signaling pathways controlled by protein kinases. Inhibition of the kinases involved can interrupt aberrant signaling and have a specific therapeutic effect. Protein kinases are recognized as validated therapeutic targets for the treatment of a number of diseases and there are considerable efforts to discover new kinase inhibitors suitable for drug development. The main goal of this study was to fabricate the synthetic imitations of the adenosine triphosphate (ATP) binding cleft in protein kinases and thus produce polymers suitable for screening and isolation of new protein kinase ATP‐mimetic inhibitors from different sources. Such polymers were created by the imprinting of tri‐O‐acetyladenosine in acrylic polymer matrix with the use of methacrylic acid (MAA) or 3‐vinylbenzoic acid (VBA) as a functional monomer and ethylene glycol dimethacrylate as a cross‐linking agent. The imprints prepared with the use of VBA demonstrate substantially better binding efficiency than that with MAA and particularly high affinity to the initial template (Kd as low as 1.2 μM), sufficient concentration of binding sites N (up to 32 μmol g−1), and pronounced specificity (imprinting factor up to 11). Under flow conditions, the fabricated polymers also demonstrate high capacity and template affinity. The produced imprints reproduce spatially noncovalent interactions present in the ATP binding site of protein kinases and can be anticipated as approximate synthetic imitations of the binding cleft.
Metacognition‐Oriented Social Skills Training for Individuals with Long‐Term Schizophrenia: Methodology and Clinical Illustration
Authors: Ottavi Paolo , D'Alia Daria , Lysaker Paul , Kent Jerillyn , Popolo Raffaele , Salvatore Giampaolo , Dimaggio Giancarlo 
Published: June 2013

PurposeThere is much evidence indicating the presence of social deficits in schizophrenia and the detrimental effect of these deficits on global functioning in this population. As a result, social skills training (SST) has emerged as a legitimate psychosocial treatment, although effectiveness research has revealed small effect sizes and limited generalizability regarding the benefits of this treatment.MethodsIn light of the strong evidence of metacognitive deficits in schizophrenia and the importance of metacognition to successful social functioning, we propose a novel therapeutic intervention wherein metacognitive remediation is integrated into SST: metacognition‐oriented social skills training (MOSST). In the current paper, we present MOSST, an adapted SST programme wherein clients are also encouraged to have mindful contact with their own thoughts and to better consider and understand the mental states of others as well as the connection between mental states and behaviour.ResultsWe present a case wherein an individual with schizophrenia successfully completed the MOSST programme.ConclusionWe outline directions for future research, starting with the logical next step of empirically testing the efficacy of MOSST. Copyright © 2013 John Wiley & Sons, Ltd.Key Practitioner MessageCurrently social skills training is considered to be the elected psychosocial treatment for people affected by schizophrenia, although evidence indicates limited benefits.People with schizophrenia have metacognitive deficits, which interfere with proper social functioning.A metacognitive‐oriented social skills training (MOSST) intervention has been developed by the authors.A treatment such as MOSST, which integrates social skills training and metacognitive training, promises to improve social skills through improving the metacognition.
Preparation of Cobalt Oxide Nanoclusters/Overoxidized Polypyrrole Composite Film Modified Electrode and Its Application in Nonenzymatic Glucose Sensing
Authors: Yu Hao , Jin Jun , Jian Xuan , Wang Yi , Qi Guang‐cai 
Published: June 2013

AbstractA cobalt oxide nanocluster/overoxidized polypyrrole composite film electrochemical sensing interface was fabricated by two step electrochemical method. The electrochemical properties and electrocatalytic activity of the resulting modified electrode were also studied carefully. The results showed that this modified electrode exhibited good stability, good anti‐interference ability, as well as high electrocatalytic activity to the oxidation of glucose. The linear range for the amperometric determination of glucose was 2.0×10−7–2.4×10−4 mol L−1 and 2.4×10−4–1.4×10−3 mol L−1 with a detection limit of 5.0×10−8 mol L−1 (S/N=3), respectively. The sensitivity was 1024 µA mM−1 cm−2.