bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAKTOR-FAKTOR YANG MEMPENGARUHI PERILAKU PENCEGAHAN PENYALAHGUNAAN NARKOBA PADA SISWA DI SMA â€œXâ€ PONTIANAK KALIMANTAN BARAT
Authors: Baharuddin Fitriah , Ratna Dwi 
Published: August 2024

ABSTRACTBackground: The highest drug abuse cases in Pontianak in 2016 are at the age of 20-30 years (88 people). Based on the level of education, the highest are at Senior High School (89 people). The district of East Pontianak is the largest drug user area (79 people). The Senior High School â€œXâ€ is a school with the highest number of students in the distict of East Pontianak.Research Method:This type of research is descriptive quantitative analytic with cross sectional approach. The population of this research is the students of class X and XI from Senior High School â€œXâ€ Pontianak, West Kalimantan which amounts 594 students. The technique of this research is proportionate stratified random sampling by using Slovin formula, got 86 samples.Research Result: The knowledge of students Senior High School â€œXâ€ about drug abuse 50,00%Â is good, the attitude of students about drug abuse 61,63% is good, the attitude of health workers 55,81% is not good, and the behavior of drug abuse prevention 67,44% is good. Multivariate test result indicate a significant influence between knowledge and drug abuse prevention behavior, the result of p value is 0,004 < 0,05. There is a significant influence between the attitude and drug abuse prevention behavior, the result of p value is 0,003 < 0,05. There is a significant influence between the attitude of healt worker and drug abuse prevention behavior, the result of p value is 0,005 < 0,05. The attitude variable is a dominant variable that effect (6.546) to the drug abuse prevention behavior.Conclusion: There is a significant influence between knowledge and behavior of drug abuse prevention. There is a significant influence between health worker and behavior of drug abuse prevention. Attitude is the most influence variable to the behavior of drug abuse prevention.Key Words: Knowledge, attitude, behavior, drug.
ANALISA EFEKTIFITAS PENGGUNAAN ALAT RESUSITASI JANTUNG PARU OTOMATIS PADA PASIEN DENGAN HENTI JANTUNG: TELAAH LITERATUR
Authors: Tanda Sucipto Dwi 
Published: August 2024

Background: Emergency is a sudden event that requires immediate action. Heart disease is a disease that is still a major problem in the world. Heart disease is a disorder of the circulatory system. Complications resulting from heart disease are cardiac arrest. Automatic CPR tools can help solve problems in reducing the effectiveness of doing CPR manually. The main problem with manual CPR is the helper's fatigue when doing CPR.Objective: This study aimed to examine technology related to the use of automatic CPR devices in patients with cardiac arrest.Methods: This method used literature review. The data was taken from several scientific sources based on PubMed, EBSCOhost, ProQuest, ScienceDirect and Wiley Library Online. This study used criteria and keywords.Result: The use of automatic tools can provide more consistent compression (speed and depth) than manual compression. But AHA did not recommend the use of automatic tools because there was no evidence that automated tools provides better results than manual compression.Conclusion: The assumption of future development was that technological progress in carrying out CPR can automatically increase the effectiveness of the performance of the tool.Â Keywords : CPR, Automatic, compression too
Terapi Thought Stopping pada Pasien Gangguan Persepsi Sensori Halusinasi: Studi Kasus
Authors: Wahyuni Sri , Wahyuni Sri , Rosdiar Rosdiar 
Published: August 2024

Background of Study: Hallucinations are one of the symptoms of mental disorders in which patients experience changes in sensory perception, as well as feeling false sensations in the form of sound, sight, taste, touch, or smell. This research explains Thought Stopping therapy which is used to reduce signs of hallucinations.
Methods: his case study uses the Psychotic Symptom Rating Scales (PYSRAT) instrument to measure signs of hallucinatory symptoms before and after Thought Stopping therapy. The number of patients who received therapy was 3 patients.
Results: igns of hallucinations. This case study uses the Psychotic Symptom Rating Scales (PYSRAT) instrument to measure signs of hallucinatory symptoms before and after Thought Stopping therapy. Before therapy, the questionnaire score obtained in patient 1 was 25, patient 2 was 30, and patient 3 was 11. After being implemented for 5 consecutive days, it was found that 2 of the 3 patients experienced a decrease in the score for signs of hallucinations, namely patient 1 obtained a score of 21 and patient 2 was 25. Meanwhile, patient 3 did not experience a decrease in score due to several obstacles, namely the patient's focus.
Conclusion: ased on the results of this application, thought stopping therapy can be used as additional therapy for patients with hallucinations by paying attention to the criteria for patients who will be given therapy such as cooperative patients, patients with phase 1 hallucinations, patients with good concentration and a calm environment
Keywords: Case Study; Hallucination; Schizophrenia; Thought Stopping Theraphy
Ketepatan Pengodean Diagnosis dan Tindakan Medis 10 Penyakit Terbanyak
Authors: Putri Sisilia , Yulia Noor , Indawati Laela , Dewi Deasy Rosmala 
Published: August 2024

Latar Belakang: Keakuratan pengkodean diagnosis dan prosedur medis sangat penting bagi rumah sakit untuk memudahkan penyajian informasi data dan sebagai penentu pembiayaan. Tujuan dari penelitian ini adalah untuk menganalisis keakuratan pengkodean diagnosis dan prosedur medis 10 penyakit terbanyak pada bulan Februari 2023 di RSUD Kembangan.

Metode : Metode penelitian menggunakan metode deskriptif dengan pendekatan analisis kuantitatif. sampel dengan jumlah 55 rekam medis yang diambil dengan teknik simple random sampling.

Hasil : Rumah sakit belum memiliki SPO khusus untuk pengodean dan prosedur medis, dari 55 sampel didapatkan hasil yang akurat untuk pengodean diagnosa 10 penyakit pada bulan Februari 2023, sebanyak 28 sampel tepat (51%) dan 25 sampel tidak tepat (49%), atau memiliki pengodean prosedur medis sebesar (66%) dan tidak tepat sebesar (34%).

Kesimpulan : Masih banyak terjadi ketidaktepatan pengkodean diagnosis dan prosedur medis di RSUD Kembangan yang mengakibatkan ketepatan diagnosis dan tindakan medis tidak mencapai 100%. Hal ini kemungkinan disebabkan karena belum adanya SPO khusus untuk diagnosis dan tindakan medis serta belum adanya petugas koding yang ahli dalam bidang koding.

Kata Kunci : Akurasi Koding; 10 Penyakit Terbanyak
Microbiota intestinal y su relación con la obesidad en adultos: artículo de revisión
Authors: Cashabamba Padilla Franklin Hernán 
Published: August 2024

Introducción: el microbiota intestinal ha emergido como un componente crucial para el mantenimiento de la salud humana, desempeñando roles fundamentales en la digestión, metabolismo, inmunidad, la regulación del estado nutricional y homeostasis energética. Sin embargo, la disbiosis (alteración del equilibrio del microbiota) puede causar obesidad, mediante mecanismos inflamatorios, aumento de la permeabilidad intestinal y cambios en el apetito. Objetivo: determinar la relación entre la alteración del microbiota intestinal y la obesidad en adultos. Metodología: el diseño de investigación es de tipo documental, exploratorio y descriptivo. Se realizó una revisión sistémica de los últimos 5 años de la literatura existente en bases de datos electrónicas como Scopus, PubMed, Science direct, Web of Science, y Google académico. Se aplicaron criterios de inclusión y exclusión. Resultados: aunque no se puede afirmar que el microbiota intestinal sea la causante directa de la obesidad en adultos, si existe una relación compleja y bidireccional entre los ambos. La disbiosis intestinal puede influir en el desarrollo de la obesidad, y esta a su vez puede modificar el microbiota intestinal. Los mecanismos principales son alteración en el metabolismo energético, proceso inflamatorios y regulación del apetito. Conclusión: la obesidad es una enfermedad metabólica crónica con múltiples factores causantes y el microbiota intestinal es solo uno de ellos. La alteración del microbiota intestinal está relacionada con la obesidad en adultos por lo que se debe manejar de manera integral, lo que incluye modificación en el estilo de vida y en ocasiones tratamiento médico. Área de estudio general: Medicina. Área de estudio específica: Microbiología. Tipo de estudio: Artículo de Revisión.
Implementasi Program Belajar Mandiri Dalam Meningkatkan Sikap Percaya Diri Siswa Di SMA Trensains Tebuireng Jombang
Authors: Budiman Arif , Ridlwan Burhanuddin 
Published: August 2024

Belajar mandiri yaitu meningkatkan kemauan dan keterampilan pembelajaran dalam proses belajar tanpa melibatkan oang lain dan tidak bergantung pada pembimbing, teman, atau orang lain. Sikap percaya diri adalah suatu sikap atau keyakinan atas kemampuan diri sendiri, sehingga dalam melakukan tindakan tidak memiliki keraguan. Penelitian ini membahas tentang Implementasi Program Belajar Mandiri Dalam Meningkatkan Sikap Percaya Diri Siswa Di SMA Trensains Tebuireng Jombang. Adapun fokus Ppnelitannya adalah 1) Bagaimana Program Belajar Mandiri Di SMA Trensains Tebuireng Jombang?. 2) Bagaimana Sikap Percaya Diri Siswa Di SMA Trensains Tebuireng Jombang?. 3) Bagaimana Implementasi Program Belajar Mandiri Dalam Meningkatkan Sikap Percaya Diri Siswa Di SMA Trensains Tebuireng Jombang?. Adapun penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Teknik pengumpulan data dalam penelitian ini dilakukan dengan menggunakan metode wawancara, observasi dan dokumentasi. Informan pada penelitian ini terdiri dari kepala sekolah, Guru dan siswa. Dari hasil penelitian ini dapat disimpulkan bahwa 1) SMA Trensains Tebuireng Jombang mendorong agar setiap siswanya memiliki cara belajarnya sendiri. 2) Percaya diri sudah menjadi keharusan bagi para siswanya. 3) Program belajar mandiri dalam meningkatkan sikap percaya diri di SMA Trensains Tebuireng Jombang dilakukan agar siswa dapat mengembangkan potensi-potensi yang dimiliki dengan cara mereka sendiri.
Kata Kunci : Belajar Mandiri, Sikap Percaya Diri
Lipid on stroke in intracranial artery atherosclerotic stenosis: a mediation role of glucose
Authors: Li Sheng , Wang Yiqing , Zhu Xiangyi , Zheng He , Ni Jianqiang , Li Hao , Yang Yi 
Published: August 2024

ObjectiveExpanding on previous investigations, this study aims to elucidate the role of lipid metabolism disorders in the development of intracranial atherosclerotic stenosis (ICAS) and the determination of stroke risk. The primary objective is to explore the connections between lipid parameters and acute ischemic stroke (AIS), while also examining the potential mediating influence of fasting glucose levels.MethodsRetrospectively, we collected data from symptomatic ICAS patients at the First Affiliated Hospital of Soochow University, including their baseline information such as medical histories and admission blood biochemical parameters. Stenotic conditions were evaluated using magnetic resonance imaging, computed tomography angiography, or digital subtraction angiography. The associations between lipid parameters and AIS risks were investigated via multivariate logistic regression analysis.ResultsA total of 1103 patients with symptomatic ICAS were recruited, among whom 441 (40.0%) suffered new ischemic events during hospitalization. After adjusting for confounding factors, the RCS curves exhibited a dose-response relationship between the atherogenic index of plasma (AIP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and AIS. Further multivariate analysis revealed significant associations between these parameters and AIS. Furthermore, mediation analysis indicated that fasting blood glucose (FBG) acted as a mediator in the association between lipid parameters (AIP, TC, and TG) and AIS.ConclusionHigher lipid parameters in ICAS patients, particularly AIP, TC, and TG, were associated with an increased AIS risk. Additionally, FBG may mediate stroke risk in ICAS patients, highlighting the need for further exploration of underlying mechanisms.
Identification of key metabolism-related genes and pathways in spontaneous preterm birth: combining bioinformatic analysis and machine learning
Authors: Lv Wenqi , Xie Han , Wu Shengyu , Dong Jiaqi , Jia Yuanhui , Ying Hao 
Published: August 2024

BackgroundSpontaneous preterm birth (sPTB) is a global disease that is a leading cause of death in neonates and children younger than 5 years of age. However, the etiology of sPTB remains poorly understood. Recent evidence has shown a strong association between metabolic disorders and sPTB. To determine the metabolic alterations in sPTB patients, we used various bioinformatics methods to analyze the abnormal changes in metabolic pathways in the preterm placenta via existing datasets.MethodsIn this study, we integrated two datasets (GSE203507 and GSE174415) from the NCBI GEO database for the following analysis. We utilized the “Deseq2” R package and WGCNA for differentially expressed genes (DEGs) analysis; the identified DEGs were subsequently compared with metabolism-related genes. To identify the altered metabolism-related pathways and hub genes in sPTB patients, we performed multiple functional enrichment analysis and applied three machine learning algorithms, LASSO, SVM-RFE, and RF, with the hub genes that were verified by immunohistochemistry. Additionally, we conducted single-sample gene set enrichment analysis to assess immune infiltration in the placenta.ResultsWe identified 228 sPTB-related DEGs that were enriched in pathways such as arachidonic acid and glutathione metabolism. A total of 3 metabolism-related hub genes, namely, ANPEP, CKMT1B, and PLA2G4A, were identified and validated in external datasets and experiments. A nomogram model was developed and evaluated with 3 hub genes; the model could reliably distinguish sPTB patients and term labor patients with an area under the curve (AUC) &gt; 0.75 for both the training and validation sets. Immune infiltration analysis revealed immune dysregulation in sPTB patients.ConclusionThree potential hub genes that influence the occurrence of sPTB through shadow participation in placental metabolism were identified; these results provide a new perspective for the development and targeting of treatments for sPTB.
Simultaneous detection of multiple urinary biomarkers in patients with early-stage diabetic kidney disease using Luminex liquid suspension chip technology
Authors: Li Xinran , Zhang Xinxin , Wang Shenglan , Li Yuan , Meng Cheng , Wang Jingyu , Chang Baocheng , Yang Juhong 
Published: August 2024

BackgroundSeveral urinary biomarkers have good diagnostic value for diabetic kidney disease (DKD); however, the predictive value is limited with the use of single biomarkers. We investigated the clinical value of Luminex liquid suspension chip detection of several urinary biomarkers simultaneously.MethodsThe study included 737 patients: 585 with diabetes mellitus (DM) and 152 with DKD. Propensity score matching (PSM) of demographic and medical characteristics identified a subset of 78 patients (DM = 39, DKD = 39). Two Luminex liquid suspension chips were used to detect 11 urinary biomarkers according to their molecular weight and concentration. The biomarkers, including cystatin C (CysC), nephrin, epidermal growth factor (EGF), kidney injury molecule-1 (KIM-1), retinol-binding protein4 (RBP4), α1-microglobulin (α1-MG), β2-microglobulin (β2-MG), vitamin D binding protein (VDBP), tissue inhibitor of metalloproteinases-1 (TIMP-1), tumor necrosis factor receptor-1 (TNFR-1), and tumor necrosis factor receptor-2 (TNFR-2) were compared in the DM and DKD groups. The diagnostic values of single biomarkers and various biomarker combinations for early diagnosis of DKD were assessed using receiver operating characteristic (ROC) curve analysis.ResultsUrinary levels of VDBP, RBP4, and KIM-1 were markedly higher in the DKD group than in the DM group (p &lt; 0.05), whereas the TIMP-1, TNFR-1, TNFR-2, α1-MG, β2-MG, CysC, nephrin, and EGF levels were not significantly different between the groups. RBP4, KIM-1, TNFR-2, and VDBP reached p &lt; 0.01 in univariate analysis and were entered into the final analysis. VDBP had the highest AUC (0.780, p &lt; 0.01), followed by RBP4 (0.711, p &lt; 0.01), KIM-1 (0.640, p = 0.044), and TNFR-2 (0.615, p = 0.081). However, a combination of these four urinary biomarkers had the highest AUC (0.812), with a sensitivity of 0.742 and a specificity of 0.760.ConclusionsThe urinary levels of VDBP, RBP4, KIM-1, and TNFR-2 can be detected simultaneously using Luminex liquid suspension chip technology. The combination of these biomarkers, which reflect different mechanisms of kidney damage, had the highest diagnostic value for DKD. However, this finding should be explored further to understand the synergistic effects of these biomarkers.
Oxidative stress mediates the association between triglyceride-glucose index and risk of cardiovascular and all-cause mortality in metabolic syndrome: evidence from a prospective cohort study
Authors: Yang Ming , Shangguan Qing , Xie Guobo , Sheng Guotai , Yang Jingqi 
Published: August 2024

BackgroundThe aim of this study was to investigate the relationship between triglyceride-glucose (TyG) index and cardiovascular disease (CVD) and all-cause mortality in adults with metabolic syndrome (MeS) and explore the mediating role of oxidative stress.MethodsThis study included 6131 adults with MeS from the National Health and Nutrition Examination Survey (NHANES). The relationships between TyG index and mortality were elucidated using multivariate Cox proportional hazards models, restricted cubic splines (RCS) Fine-Gray competing risk model. In addition, mediation analysis was used to test the indirect effect of oxidative stress indicators.ResultsOver a median 106-month follow-up, a total of 357 CVD and 1292 all-cause deaths were recorded. After multivariate adjustment, there was a J-type relationship between TyG index and CVD and all-cause mortality, with optimal inflection point of 9.13 and 8.92. After the threshold point, TyG index was positively associated with CVD (HR: 4.21, 95%CI: 1.82, 9.78) and all-cause mortality(HR: 2.93, 95%CI: 2.05, 4.18). Even using non-cardiovascular mortality as a competitive risk, the Fine-Gray model also illustrated that the cumulative CVD mortality incidence was higher in MeS with TyG index &gt;9.13 (Fine-Gray P&lt; 0.01). Mediation analysis revealed that biomarkers of oxidative stress, including gamma-glutamyl transferase and uric acid, collectively mediated 10.53% of the association between the TyG index and CVD mortality, and 8.44% of the association with all-cause mortality (P &lt; 0.05).ConclusionIn the cohort study, TyG index was found to have a J-shaped association with CVD mortality and all-cause mortality in MeS population and oxidative stress may play a key mediating role in this relationship.
Post-marketing drug safety surveillance of enfortumab vedotin: an observational pharmacovigilance study based on a real-world database
Authors: Yu Mingming , Zhou Lijun , Cao Mengda , Ji Chunmei , Zheng Yuanyi 
Published: August 2024

BackgroundEnfortumab vedotin (EV) is an antibody-drug conjugate (ADC) that has been approved by the FDA for patients with locally advanced or metastatic urothelial carcinoma (UC). This study presents a comprehensive pharmacovigilance analysis of the post-marketing safety profile of EV in the real-world based on the US Food and Drug Administration Adverse Event Reporting System (FAERS).MethodsAdverse event (AE) reports regarding EV between January 2020 and December 2023 were obtained from the FAERS database. The standardized MedDRA query (SMQ) narrow search AEs on the preferred term (PT) level were used. Disproportionality analysis was performed to identify the AE signals for EV with the reporting odds ratio (ROR), proportional reporting ratio (PRR), multi-item gamma Poisson shrinker (MGPS), and Bayesian confidence propagation neural network (BCPNN).ResultsA total of 2,216 reports regarding EV were included in the present study. SMQ analysis results indicated that a stronger strength signal was found in severe cutaneous adverse reactions, retroperitoneal fibrosis, and peripheral neuropathy. A total of 116 significant disproportionality PTs referring to 14 system organ classes (SOCs) were retained by disproportionality analysis, with 49 PTs not listed on the EV drug label. Frequently reported EV-related AEs included rash, peripheral neuropathy, decreased appetite, alopecia, and pruritus. The time to onset of the majority of EV-related AEs was within 30 days (66.05%), with only 0.73% events occurring after 1 year.ConclusionThe disproportionality analysis highlights that dermatologic toxicity and peripheral neuropathy were the major AEs induced by EV. The potential AEs not listed on the drug label were mainly related to gastrointestinal, hepatic, and pulmonary events. Further research is needed to confirm and explore the EV-related AEs in clinical practice.
Peripheral blood T-cell modulation by omalizumab in chronic urticaria patients
Authors: López Cristina , Depreux Nathalie , Bielsa Isabel , Roger Albert , Quirant-Sanchez Bibiana , Basagaña Maria , Jurgens Yanina , Padró Clara , Miquel Sira , Martinez-Caceres Eva , Teniente-Serra Aina 
Published: August 2024

BackgroundChronic spontaneous urticaria (CSU) is a highly prevalent and difficult to manage cutaneous disease characterized by the presence of recurrent urticaria, angioedema, or both, for a period of 6 weeks or longer. One of the biological treatments used for patients with CSU with an autoimmune background and bad control of the disease is omalizumab, an anti-IgE monoclonal antibody. The understanding of the mechanism of action of this biological drug in CSU along with the identification of potential biomarkers of clinical response can be helpful in the personalized management of the disease.ObjectiveThe purpose of this study was to analyze the effect of omalizumab on peripheral blood lymphocyte subpopulations in patients with CSU in order to identify potential biomarkers of treatment response.MethodsWe analyzed 71 patients with CSU [33 under omalizumab and 38 under non-immunomodulatory drugs (treated with antihistamines; NID)] and 50 healthy controls. An exhaustive immunophenotyping of whole blood T-cell subpopulations, including naïve, central memory, effector memory, effector cells, Th1, Th2, and Th17 was performed by multiparametric flow cytometry. Moreover, in CSU patients, we analyzed markers of inflammation (ESR, DD, CRP), atopy (prick test, IgE quantification), and autoimmunity (anti-thyroid antibodies and indirect basophil activation test).To evaluate the clinical activity, the Urticaria Activity Score 7 (UAS 7) test was used.ResultsIn patients with CSU under treatment with omalizumab, there was a significant decrease in the percentage of naïve and an increase in the percentage of central memory CD4 T cells as well as a decrease in the percentage of naïve and increase in the percentage of effector CD8 T-cell subsets. Moreover, patients under treatment with omalizumab had higher percentages of Th1 and Th2 cells than patients under treatment with NID.ConclusionThe immune monitoring of T-cell subpopulations in patients with CSU starting omalizumab, may be a useful strategy to analyze treatment response in the clinical practice.