bluuebunny/crossref_metadata_2025_split huggingface dataset:
The protective effect of karanjin against sepsis‐induced acute lung injury in mice is involved in the suppression of the TLR4 pathway
Authors: Zhang Chujie , Ma Juncong , Liu Chang , Yan Xianliang 
Published: July 2024

AbstractSepsis‐induced acute lung injury (ALI) is a severe complication of sepsis. Karanjin, a natural flavonoid compound, has been proved to have anti‐inflammatory function, but its role in sepsis‐stimulated ALI is uncertain. Herein, the effect of karanjin on sepsis‐stimulated ALI was investigated. We built a mouse model of lipopolysaccharide (LPS)‐stimulated ALI. The histopathological morphology of lung tissues was scrutinized by hematoxylin–eosin (H&E) staining. The lung injury score and lung wet/dry weight ratio were detected. The myeloperoxidase (MPO) activity and malondialdehyde (MDA) content were scrutinized by commercial kits. Murine alveolar lung epithelial (MLE‐12) cells were treated with LPS to mimic a cellular model of ALI. The cell viability was scrutinized by the CCK‐8 assay. The contents of proinflammatory cytokines were scrutinized by qRT‐PCR and ELISA. The TLR4 and MyD88 contents were scrutinized by qRT‐PCR and western blotting. Results showed that karanjin alleviated LPS‐stimulated ALI in mice by inhibiting lung tissue lesions, edema, and oxidative stress. Moreover, karanjin inhibited LPS‐stimulated inflammation and TLR4 pathway activation in mice. However, treatment with GSK1795091, an agonist of TLR4, attenuated the effects of karanjin on LPS‐induced ALI. Furthermore, karanjin repressed LPS‐stimulated inflammatory response and TLR4 pathway activation in MLE‐12 cells. Overexpression of TLR4 attenuated karanjin effects on LPS‐stimulated inflammatory responses in MLE‐12 cells. In conclusion, karanjin repressed sepsis‐stimulated ALI in mice by suppressing the TLR4 pathway.
Common functional mechanisms underlying dynamic brain network changes across five general anesthetics: A rat fMRI study
Authors: Chen Sifan , Li Bo , Hu Ying , Zhang Yizhe , Dai Wanbing , Zhang Xiao , Zhou Yan , Su Diansan 
Published: July 2024

AbstractBackgroundReversible loss of consciousness is the primary therapeutic endpoint of general anesthesia; however, the drug‐invariant mechanisms underlying anesthetic‐induced unconsciousness are still unclear. This study aimed to investigate the static, dynamic, topological and organizational changes in functional brain network induced by five clinically‐used general anesthetics in the rat brain.MethodMale Sprague–Dawley rats (n = 57) were randomly allocated to received propofol, isoflurane, ketamine, dexmedetomidine, or combined isoflurane plus dexmedetomidine anesthesia. Resting‐state functional magnetic resonance images were acquired under general anesthesia and analyzed for changes in dynamic functional brain networks compared to the awake state.ResultsDifferent general anesthetics induced distinct patterns of functional connectivity inhibition within brain‐wide networks, resulting in multi‐level network reorganization primarily by impairing the functional connectivity of cortico‐subcortical networks as well as by reducing information transmission capacity, intrinsic connectivity, and network architecture stability of subcortical regions. Conversely, functional connectivity and topological properties were preserved within cortico‐cortical networks, albeit with fewer dynamic fluctuations under general anesthesia.ConclusionsOur findings highlighted the effects of different general anesthetics on functional brain network reorganization, which might shed light on the drug‐invariant mechanism of anesthetic‐induced unconsciousness.
Improving compliance around protected areas through fair administration of rules
Authors: Ibbett Harriet , Dorward Leejiah , Jones Julia P. G. , Kohi Edward M. , Dwiyahreni Asri A. , Sankeni Stephen , Prayitno Karlina , Mchomvu Jesca , Kaduma Joseph , Saputra Andie Wijaya , Agustin Ika Yuni , Tryswidiarini Tyassanti , Mawenya Rose , Supriatna Jatna , St John Freya A. V. 
Published: July 2024

AbstractProtected area management often depends heavily on law enforcement to secure compliance with rules. However, this can contribute to conflict between protected area authorities and local people, negatively affecting both human well‐being and conservation outcomes. Compliance is affected by many factors, including whether those who enforce rules are perceived to do so fairly, as well as the perceived rule‐related behavior of others. We used factorial survey experiments to explore how fair respondents living around protected areas in Indonesia and Tanzania perceive sanctions distributed by law enforcers to be. We presented scenarios to respondents to assess how crime type, offender characteristics, and corruption influenced their judgments regarding the fairness of administered sanctions. We also assessed how descriptive norms and corruption influenced individuals’ willingness to obey protected area rules. Data were collected from 229 people in Indonesia and 217 in Tanzania. Results showed that in both locations, lawful sanctions, such as arrests or warnings, were perceived as fairer, and sanctions that involved corruption were perceived as least fair. Attitudes toward protected area rules, corruption, and descriptive norms all influenced people's willingness to comply, whereas multidimensional poverty did not. Our results highlight the need for conservation policy and practice to move beyond narratives that focus on the need for more law enforcement. To improve protected area compliance and secure better outcomes for people and nature, conservation must focus on ensuring the fair administration of rules and enhancing the legitimacy of rules themselves.
Engaged robots, disengaged workers: Automation and political alienation
Authors: Gonzalez‐Rostani Valentina 
Published: July 2024

AbstractI investigate the impact of automation on political behavior in postindustrial societies, particularly focusing on political disengagement. I argue that structural changes in the labor market lead to political alienation due to increased economic insecurities, diminished resources from lower wages, and greater economic polarization. Using hierarchical logistic modeling with varying intercepts by country, I present evidence from survey data across several advanced democracies. I find that workers exposed to technological change are less likely to feel close to a political party, participate in elections, and take part in protests. The impact of automation on political engagement is smaller among wealthier citizens and in highly unionized environments. The political message from these interaction effects speaks to the reinforcing forces between economic inequality and automation and the role of collective organization. My findings have important implications for understanding the links between structural change in labor markets and politics, especially since disengaged workers are the reservoir for radical right parties.
Making sense of climate change in central government annual reports and accounts: A comparative case study between the United Kingdom and Norway
Authors: Edgar Victoria C. , Stewart Elaine 
Published: July 2024

AbstractTaking a sensemaking and accountability perspective, this paper explores how the Norwegian and the United Kingdom (UK) central governments understand climate change in the annual reports and accounts and how this shapes its accountability. Using a thematic analysis, we find that the Norwegian central government makes sense of climate change as a global problem requiring coordinated actions with shared responsibility and accountability to international agreements. In contrast, the UK central government understands climate change as a problem for individual departments and accountability to national guidelines. Sensemaking is enabled primarily in the narratives but also visually in the UK central government. Our research contributes to climate‐related and accounting research by illustrating how central government understands climate change. Theoretically, we extend the literature on sensemaking to the public sector and how sensemaking shapes accountability for climate change.
“This whole journey was sacred”: Latter‐day Saint parents' process in coming to accept a transgender child
Authors: Bernards Julia Campbell , Hunt Quintin , Henriques Cass , Bledsoe Angie , Ostler Richard 
Published: July 2024

AbstractThis constructivist grounded theory (CGT) study examines Latter‐day Saint (LDS) parents' process in coming to accept a transgender or gender diverse (TGD) child and the factors that impact acceptance. Data come from interviews with 38 LDS parents of TGD children and 130 Facebook posts from the same population. Data were analyzed using CGT methodology in coding and theory construction. A model of LDS parents' process in accepting a TGD child and the factors that impact that process are presented. The results indicate that coming to accept a TGD child tends to engage LDS parents cognitively, emotionally, socially, and spiritually, and is a developmental process. We identified four stages of parents' process: assimilation of new information, deconstruction and disequilibrium, reconstruction and accommodation, and acceptance; as well as typical emotional responses in each stage. We found that factors that impacted parents' process included parents' pre‐process characteristics and contexts, religiously defined meaning making, social embeddedness, external resources, community building, and spiritual autonomy. Additionally, we found that parents' commitment to their child's wellbeing and connection with their child (i.e., attachment) motivates their process and that their personal spiritual experiences tend to guide it. Parents in the study who reached a state of acceptance expressed that their process had been both deeply challenging and profoundly, personally meaningful. This study strengthens the case for using attachment‐based therapies with this population and indicates the value of incorporating spirituality into the therapeutic work.
Methodological quality of umbrella reviews in endodontics: A cross‐sectional study
Authors: Nagendrababu Venkateshbabu , Gopinath Vellore Kannan , Narasimhan Srinivasan , Acharya Anirudh B. , Dummer Paul M. H. , Faggion Clovis Mariano 
Published: July 2024

AbstractIntroductionIn endodontics, the number of umbrella reviews has increased significantly over the last few years, but there is no evidence that they were methodologically sound. The aim of the current study was to appraise the methodological quality of umbrella reviews in endodontics, and to identify possible predictive factors associated with methodological quality.MethodsUmbrella reviews published in the discipline of endodontics until December 2023 were included. The methodological quality of the reviews was evaluated using a checklist consisting of 11 items. Each item in the checklist was evaluated by two independent assessors who assigned a score of ‘1’ if it was fully addressed, ‘0.5’ if it was partially ddressed, and ‘0’ if it was not addressed. Bootstrapped multiple linear regression analysis was used to examine the association between the total scores awarded and five predictor variables (a priori protocol registration, year of publication, number of authors, journal impact factor (IF) and continent of the corresponding author). The statistical significance level was set as 5%.ResultsA total of 27 reviews were included. Ninety‐six per cent of the reviews adequately reported: eligibility criteria for selecting the reviews, details of the reviews, techniques for assessing the risk of bias or methodological quality of the individual systematic reviews they included. Only 30% of the reviews adequately managed overlapping primary studies within individual systematic reviews. Among the five predictors analysed, a priori protocol registration and journals with IFs were associated with significantly greater total methodological quality scores.DiscussionSeveral methodological shortcomings in the umbrella reviews published within the field of endodontics were revealed. Umbrella reviews published in journals with IFs and those with protocols registered a priori had significantly superior methodological quality scores.ConclusionIn endodontics, authors intending to publish umbrella reviews should consider the limitations revealed in this study and follow the appropriate rules to ensure their reviews comply with the highest standards and provide accurate and dependable information and conclusions.
Preparation of low‐cost peridotite ceramic microfiltration membrane for treating industrial wastewater
Authors: Harrati Achraf , Arkame Youssef , Adlane Sanaa , Essate Ahlam , Achiou Brahim , El Bouari Abdeslam , Aaddane Abdelleh , Alami Younssi Saad , Sadik Chaouki 
Published: July 2024

AbstractThe aim of this work is to fabricate a low‐cost ceramic microfiltration (MF) membrane made from a new geomaterial named peridotite. The membrane was prepared by uniaxial pressing and followed by sintering. The effect of sintering temperature, in the range of 1100–1225°C, on the permeability, porosity, mechanical strength, and pore size was investigated. The optimized MF membrane sintered at 1200°C exhibits 1198.9 L h−1 m−2 bar−1 of permeability, 36.41% of porosity, 12.9 MPa of mechanical strength, and 1.56 µm of pore size. The prepared membrane was used for the MF treatment of dairy wastewater. It was found that the membrane is able to remove 88.56% and 69.54% of turbidity and chemical oxygen demand, respectively. Furthermore, the cost of the peridotite membrane was estimated to be $10.3 m−2.
Optimization of Ti2O3 thin films by magnetron sputtering and study of their photoelectric performance
Authors: Wang Wenwei , He Jialiang , Yao Yingbang 
Published: July 2024

AbstractIn this study, Ti2O3 thin films were successfully produced using magnetron sputtering. Through orthogonal gradient experiments, the impact of substrate temperature, sputtering vacuum, RF power, and sputtering duration on surface morphology, roughness, physical structure, and resistivity was investigated. Various analytical techniques were employed, including AFM and SEM for surface morphology observation, XRD and Raman for qualitative physical structure analysis, XPS for elemental valence examination, and the four‐probe method for resistivity measurements. The study identified optimal growth conditions for Ti2O3 films, demonstrating a low resistivity of 2.66 × 10−3 Ω cm under the following conditions: RF power of 200 W, sputtering vacuum of .6 Pa, substrate temperature of 600°C, and sputtering duration of 60 min. Additionally, the sensor arrays were efficiently fabricated using the Lift‐off method to evaluate the photoelectric performance of the films. A light responsiveness of approximately 6 µA/W was observed in the device when illuminated with 950 nm light for 10 s. This finding carries important implications for the use of Ti2O3 thin films in future photoelectric devices.
Development and structural characterisation of gelatin‐based sustainable food packaging from turkey (Meleagris gallopavo) skin by‐product
Authors: Ozcan Yilmaz , Kurt Abdullah , Yildirim‐Yalcin Meral , Toker Omer Said 
Published: July 2024

SummaryIn view of the environmental problems resulting from plastic‐based packaging, gelatin film production from alternative, sustainable sources are extremely important. The objective of this study was to utilise a major source of collagen derived from poultry waste to produce and characterise turkey skin gelatin films (TGF). TGFs were produced at different glycerol concentrations (20%, 30% and 40%) via solvent casting technique. TGFs characteristics were also compared with the bovine gelatin films (BGF). The thermal structural development of TGF solutions to form a film network was not affected by the glycerol content in the temperature sweep test. This property was determined earlier and at higher temperatures in TGF (22 °C–23 °C) than in BGF (19 °C). As the glycerol ratio increased, the moisture content increased from 14.80% to 22.46%, while the thickness (36 μm) and density (1.134–1.247 g cm−3) of TGFs remained constant due to the compact structures. The water vapour transmission rates of TGFs and BGF were similar (P >0.05), ranging from 0.48 to 0.53 g mm m−2 h−1 kPa−1. Lower solubility was found for TGF20 (44.78%) and TGF30 (63.59%) films compared to BGF30 (63.59%). TGF20 exhibited the highest tensile strength and lowest elongation at break values. TGF40 and BGF30 demonstrated the highest flexibility and extensibility (P >0.05). In XRD analysis, TG40 demonstrated a less amorphous film structure compared to BG30, since the increased interaction due to glycerol provided a more ordered polymeric structure. TG20 and TG30 showed lower decomposition rates and higher residue levels, indicating their higher thermal stability. Thus, gelatin films based on turkey skin could be the alternative natural biodegradable films with suitable glycerol content for desired mechanical, barrier and thermal properties.
High prevalence of diabetes in a regional Australian hospital highlights the need to prioritise inpatient diabetes care
Authors: Fogarty Michael , Hung Annie , Fearnside Katie , Hazara Ali , Goh Amanda , Agarwal Ankira , Siever Miriam , Kyi Mervyn , Barmanray Rahul , Wang Ray , Johnson Douglas , Puri Gaurav , Fourlanos Spiros 
Published: July 2024

AbstractRegional centres have smaller workforces in acute diabetes care compared to their metropolitan counterparts. A cross‐sectional audit performed at Albury Hospital identified a high prevalence (34%) of diabetes for inpatients compared with metropolitan centres. The high prevalence highlights the need for all healthcare services to consider appropriate resources for the management of diabetes in people admitted to hospital.
Early postoperative infection in patient with IgM deficiency
Authors: Chan Kayen , Loh Charles Yuen Yung 
Published: July 2024

AbstractSelective IgM deficiency is a rare immunological disorder, with patients presenting with recurrent infections and allergic manifestations. However, the association with early postoperative infection has not been widely reported in the literature. We describe a rare case of a patient who had an early wound infection 1 day after excision of a Merkel cell carcinoma from his right buttock and was later found to have decreased IgM levels. Selective IgM deficiency should therefore be considered in patients presenting with recurrent infections or in patients who have previously undergone surgery and subsequently developed early infection postoperatively. In this subset of patients, extra precautions may need to be taken pre‐ and postoperatively to reduce the risk of developing a postoperative infection.
Evolution of dupilumab‐associated conjunctivitis in patients with atopic dermatitis after switching dupilumab to tralokinumab or Janus kinase inhibitors (RESO‐ADOC study)
Authors: Reguiai Ziad , Becherel Pierre André , Perrot Jean Luc , Boulard Claire , Fougerousse Anne Claire , Begon Edouard , Badaoui Antoine , Poreaux Claire , Parier Josiane , Liegeon Anne‐Laure , Levavasseur Matthieu , Bing Anne‐Claire , Estève Eric , Maccari François ,   the GEM reso‐Dermatologie and OMCCI Group
Published: July 2024

AbstractBackgroundClinical trials and real‐life data have reported an increased incidence of conjunctivitis in patients treated with dupilumab for their atopic dermatitis (AD). Although mostly mild in severity, in some cases conjunctivitis will appear or increase after dupilumab initiation, which can lead to dupilumab discontinuation.Objectives(1) To describe the characteristics of patients developing conjunctivitis requiring discontinuation of dupilumab; and (2) to analyse the factors associated with a complete conjunctivitis improvement after dupilumab discontinuation and a switch to tralokinumab or Janus kinase inhibitors.MethodsThis was a multicentre retrospective cohort study that included all patients with AD treated with dupilumab who developed conjunctivitis leading to dupilumab discontinuation and switching to tralokinumab or Janus kinase inhibitors in daily practice. Data on patients, their AD and conjunctivitis were analysed at the inclusion visit (corresponding to discontinuation of dupilumab and the institution of new AD treatment), at visit 2 (3–6 months after inclusion) and at visit 3 (corresponding to the last medical visit).ResultsAfter multivariate analysis, the only factors associated with a complete resolution of dupilumab‐associated conjunctivitis at visit 2 and/or visit 3 were conjunctivitis duration (OR 8.98, 95% CI 1.47–55) (p = 0.018), personal history of asthma (OR 10.66, 95% CI 1.82–62.63) (p = 0.009) and switching from dupilumab to Janus kinase inhibitors (OR 17.11, 95% CI 2.94–99.66) (p = 0.002).ConclusionsAlthough uncommon, severe dupilumab‐associated conjunctivitis is more frequent in daily life compared to its incidence in the dupilumab pivotal trials. In these cases, our study suggests that a rapid switch to another molecule, particularly a Janus kinase inhibitor, should be considered.
Go green: How does Green Credit Policy promote corporate green transformation in China
Authors: Tan Weijie , Yan Edward Hengzhou , Yip Wai Sze 
Published: July 2024

AbstractOur study explores the relationship between Green Credit Policy (GCP), bank competition, and corporate green transformation. Previous research mainly focused on the impact of GCP on corporate green practices from a single dimension, with limited attention to bank competition and the overall process of corporate green transformation. Using machine learning methods and Baidu Maps API, we innovatively construct indicators for the green transformation of Chinese A‐share‐listed companies and bank competition from 2007 to 2020. We treat China's Green Credit Guidelines as a quasi‐experiment and find that GCP has a positive impact on corporate green transformation, with bank competition strengthening this effect. Notably, the influence of state‐owned banks and foreign banks is more pronounced. Mechanism analysis indicates that alleviating financing constraints and promoting green behavior are critical mechanisms through which GCP affects green transformation. Furthermore, this effect is more pronounced in state‐owned enterprises, companies with high environmental transparency, regulated industries, and regions with stronger environmental regulations.
Effect and mechanism of Tricholoma matsutake extract combined with bakuchiol and ergothioneine on UVB‐induced skin aging
Authors: Hu Lu , Weng Jiyu , Wang Ziqin , Huang Chujie , Zhang Lanyue 
Published: July 2024

AbstractBackgroundAging is a physiological phenomenon in the process of life, and skin aging has a significant impact on human appearance. Therefore, the search for methods to delay skin aging is of great significance for improving the quality of human life.Materials and MethodsThis study investigated the anti‐photoaging effect of Tricholoma matsutake (T) extract composition combined with bakuchiol (B) and ergothioneine (E), and explored its potential mechanism through transcriptome, metabolomics, and network pharmacology.Results57 main chemical components are identified from the ethanol extract of T. matsutake (T), including D‐carnitine (24.55%), α,α‐trehalose (15.56%), DL malic acid (8.99%), D‐(−)‐quinic acid (7.46%), erucamide (7.04%) and so on. After TBE treatment, inflammation of the mice dorsal skin is significantly minimized. Hematoxylin and eosin (H&E) staining and toluidine blue staining reveal that TBE has an anti‐inflammatory effect on the back skin tissue of mice. Masson staining shows that TBE has a repair effect on mice dorsal skin tissue. In addition, the inflammatory factors (IL‐1β, IL‐6, TNF‐α) in the mice dorsal skin tissues are significantly reduced but collagen (COL‐1) is significantly increased. By cellular immunofluorescence assay, TBE is shown to promote PPAR‐α expression in cells. Transcriptomics, metabolomics, and network pharmacology have revealed that TBE can regulate exogenous stimuli and cancer‐related signaling pathways to prevent skin aging.ConclusionThe results suggest that TBE can be a beneficial supplement to natural anti‐aging.