bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances in Pretargeted Strategy for Cancer Theranostics
Authors: Tian Yuyang , Huang Zheng , Luo Jiewei , Ye Deju 
Published: July 2024

AbstractIn nuclear medicine, theranostic probes that combine nuclear imaging capabilities with therapeutic functions have shown promise for the diagnosis and treatment of cancers. Nevertheless, the development of theranostic probes may be constrained by two principal factors: (1) the discrepancy between the slow accumulation time of the probes in the tumours and the short‐lived radionuclides, and (2) the suboptimal imaging/treatment effect and high radioactive toxicity caused by long‐lived radionuclides. In recent years, pretargeted strategy has been proposed as a potential solution to solve these problems. In the pretargeted strategy, two components consisting of a tumour‐targeting vector (e. g., antibody) and a radionuclide are injected separately, which can then couple in the tumour tissues to trap radionuclides for nuclear imaging and/or therapy. This two‐step process allows for the independent optimization of the pharmacokinetics of them in vivo, benefiting to improve nuclear imaging and/or therapy of tumours in vivo. In this concept, we will discuss the principle of the pretargeted strategy, with a focus on the discussion of different tumour‐targeting vectors, including antibody‐mediated delivery, nanoparticle‐mediated delivery, metabolic glycan labeling‐mediated accumulation, and enzyme‐triggered in situ self‐assembly‐mediated retention. Finally, we will discuss the current challenges and perspectives on their applications for cancer theranostics in clinics.
Health insurance literacy among patients receiving outpatient cancer treatment
Authors: Zhao Jingxuan , Zhang Nan , Hilal Talal , Griffin Joan M. , Yabroff K. Robin , Khera Nandita 
Published: July 2024

AbstractBackgroundThis study examines patients’ understanding of health insurance terms and concepts and quantifies health insurance literacy (HIL) levels by key sociodemographic factors.MethodsThis study included 393 adult patients with cancer (>18 years old) receiving treatment in two ambulatory infusion centers: Mayo Clinic in Phoenix, Arizona and the University of Mississippi Medical Center in Jackson, Mississippi. Respondents’ perceptions of their HIL were assessed using the Health Insurance Literacy Measure (HILM), a validated 21‐item measure of a consumer's ability to select and use health insurance (HIL self‐efficacy). Respondents’ knowledge of health insurance concepts (HIL knowledge) was measured using 10 items created by the Kaiser Family Foundation. The number of correct answers was categorized into three levels: 0–4 (low knowledge), 5–6 (moderate knowledge), and 7–10 (high knowledge). Multivariable logistic regressions were used to compare correct answers to HIL knowledge questions by HIL self‐efficacy.ResultsNearly three‐quarters of patients had high HIL self‐efficacy and high HIL knowledge (70.5%), understanding basic insurance terms, such as premiums and deductibles. Relatively low percentages of patients correctly answered questions about the meaning of provider networks, health insurance formularies, and calculating out‐of‐pocket spending in scenarios when insurers pay a portion of allowed charges. Lower HIL knowledge was more common among patients with less educational attainment (<college: 15.2%; ≥college: 4.7%), lower household income (<$4999: 11.8%; ≥$5000: 6.1%), and low HIL self‐efficacy scores (low: 24.8%; high: 5.2) (all p values <.05).ConclusionsEfforts to improve HIL and navigation of health insurance plan features are required, especially for socioeconomically vulnerable patients.
Green Chemistry, Catalysis, and Waste Valorization for a Circular Economy
Authors: Wattanakit Chularat , Fan Xiaolei , Mukti Rino R. , Yip Alex C. K. 
Published: July 2024

AbstractThe circular economy represents an economic model that prioritizes sustainability and resource efficiency, aiming to minimize waste minimization, promote reuse, and close material loops. This Special Collection highlights recent advancements in green chemistry, catalysis, and waste valorization, fields critical for achieving sustainable practices and resource efficiency within a circular economy. Researchers from the Asia‐Pacific region, Europe, South America, and North America have contributed to designing sustainable chemical processes that minimize environmental impact. These efforts involve developing efficient reactions to reduce waste generation and resource depletion. Additionally, this Special Collection showcases examples of effective catalysts with the potential to enhance resource conservation and circularity and convert waste and biomass materials into valuable products.
Winter wheat response to plant density in yield contest fields
Authors: Lollato Romulo P. , Pradella Luiz O. , Giordano Nicolas , Ryan Luke P. , Soler Jorge R. , Simão Luana M. , Jaenisch Brent R. , Horton Rick 
Published: July 2024

AbstractSeeding rate recommendations for wheat (Triticum aestivum L.) are often 150–450 seeds m−2. However, we hypothesize that wheat grown with high resource availability (i.e., fertility and moisture) can maximize yield under considerably lower rates. Our objectives were to explore winter wheat response to low populations under high resource availability using yield‐contest fields as a case study. A factorial experiment evaluated four wheat varieties (i.e., Joe, WB‐Grainfield, Langin, and LCS Revere) exposed to five seeding rates (50, 100, 150, 200, and 250 seeds m−2) during five seasons in commercial wheat fields managed by yield‐contest winning producers near Leoti, KS. Fields were silt‐loam soils with high available water‐holding capacity, long‐term history of manure application with non‐limiting fertility, and adopted a sorghum [Sorghum bicolor (L.) Moench]–fallow–wheat rotation. Plant density ranged from 26 to 341 plants m−2 and yield ranged from 3.2 to 6.8 Mg ha−1. Water use efficiency of 19.5 kg ha−1 mm−1 suggested no management limitations to yield. Quadratic models portrayed the grain yield–plant density relation well, with 95% of the maximum yield reached at 68 to 91 plants m−2 for crops sown at the optimum date (4 out of 5 years), and at 312 plants m−2 for a late‐sown crop. Greater fall temperature accumulation reduced the relative yield between the maximum and minimum seeding rates. There was no variety × plant density interaction and Langin was the most consistent yielding variety across environments. Optimum plant density for winter wheat in environments with high resource availability may be considerably lower than current recommendations.
Cobalt‐Catalyzed Synthesis of Alkenes and Vinyl Sulfones Via Dehydrogenative Coupling of Alcohols and Sulfones
Authors: Tian Haitao , Lu Yanze , Tang Conghui 
Published: July 2024

AbstractA novel protocol to access vinyl sulfones and internal/terminal olefins via cobalt‐catalyzed acceptorless dehydrogenation coupling (ADC) has been established. This system enables the divergent synthesis of three kinds of olefin compounds through the coupling of alcohols and sulfones under oxidant‐free conditions. The broad applicability of this procedure is demonstrated by over forty olefin products, including pharmaceutical‐related compounds and complex substrates, in a one‐pot process. Preliminary mechanistic studies were conducted, and a proposed reaction pathway was presented.
Neurocognitive profiles are associated with subsequent brain integrity in a sample of Hispanics/Latinos: Findings from the SOL‐INCA‐MRI study (HCHS/SOL)
Authors: Sapkota Shraddha , Maillard Pauline , Stickel Ariana M. , Tarraf Wassim , Gonzalez Kevin A. , Ivanovic Vladimir , Morlett‐Paredes Alejandra , Cai Jianwen , Isasi Carmen R. , Lipton Richard B. , Daviglus Martha , Testai Fernando Daniel , Lamar Melissa , Gallo Linda C. , Talavera Gregory A. , Agudelo Christian , Ramos Alberto R. , González Hector M. , DeCarli Charles 
Published: July 2024

AbstractThe Hispanic/Latino population is one of the largest and most diverse ethnoracial groups in the United States at high risk for dementia. We examined cognitive constructs and associations with subsequent hippocampal volume (HV) and white matter hyperintensity volume (WMHV). Participants were from the Hispanic Community Health Study/Study of Latinos–Magnetic Resonance Imaging Study (n = 2029). We examined confirmatory factor analysis and longitudinal invariance using neurocognitive scores at Visits 1 (2008–2011) and 2 (2014–2018) and path analyses. We obtained a longitudinally invariant two‐factor episodic memory (EM) and working memory (WM) construct. Lower EM profile at both visits was associated with greater WMHV and smaller HV at Visit 2. Lower WM profile at both visits was associated with larger WMHV and smaller HV at Visit 2. Neurocognitive profiles were associated with subsequent neurodegeneration in a sample of Hispanics/Latinos. Identifying neurocognitive risk profiles may lead to early detection and intervention, and significantly impact the course of neurodegeneration.Highlights
Cognitive profiles predict brain integrity up to 10 years later.
We observed two‐factor latent memory constructs and longitudinal invariance.
These findings were observed in a Hispanic/Latino cohort.
Sodium‐enriched nectar shapes plant–pollinator interactions in a subalpine meadow
Authors: VanValkenburg Ethan , Gonçalves Souza Thiago , Sanders Nathan J. , CaraDonna Paul 
Published: July 2024

AbstractMany plants have evolved nutrient rewards to attract pollinators to flowers, but most research has focused on the sugar content of floral nectar resources. Concentrations of sodium in floral nectar (a micronutrient in low concentrations in nectar) can vary substantially both among and within co‐occurring species. It is hypothesized that sodium concentrations in floral nectar might play an important and underappreciated role in plant–pollinator interactions, especially because many animals, including pollinators, are sodium limited in nature. Yet, the consequences of variation in sodium concentrations in floral nectar remain largely unexplored. Here, we investigate whether enriching floral nectar with sodium influences the composition, diversity, and frequency of plant–pollinator interactions. We experimentally enriched sodium concentrations in four plant species in a subalpine meadow in Colorado, USA. We found that flowers with sodium‐enriched nectar received more visits from a greater diversity of pollinators throughout the season. Different pollinator species foraged more frequently on flowers enriched with sodium and showed evidence of other changes to foraging behavior, including greater dietary evenness. These findings are consistent with the “salty nectar hypothesis,” providing evidence for the importance of sodium limitation in pollinators and suggesting that even small nectar constituents can shape plant–pollinator interactions.
Triglyceride glucose index is a risk factor for heart failure: A prospective cohort study
Authors: Jia Yuan , Zhang Yue , Bai Shiru , Liu Jia , Chen Tianlei , Liu Xuda , Xu Chao , Zhang Ruining , Du Rongpin 
Published: July 2024

AbstractAimsThis study aimed to investigate the relationship between the triglyceride glucose (TyG) index and all‐cause mortality in patients with heart failure (HF).Methods and ResultsA total of 1274 patients with HF diagnosed at Hebei General Hospital were enrolled in this study. The patients were divided into four groups by quartiles based on the TyG index. The endpoint was all‐cause mortality during the follow‐up period. The median follow‐up period was 1079 days, with a total of 543 (42.7%) patients experiencing all‐cause mortality. The survival curves showed no significant difference in endpoint events among the four groups (log‐rank P = 0.329). The adjusted survival curves revealed that after adjusting for the variables in Model 3, the group with a higher TyG index exhibited a higher risk of death (log‐rank P < 0.001). The multivariate‐adjusted Cox proportional hazard models revealed a positive correlation between the TyG index and all‐cause mortality. After complete adjustment, patients with the highest TyG index exhibited a higher risk of all‐cause mortality than those in the lowest quartile [hazard ratio (HR) = 1.6, 95% confidence interval (CI): 1.22–2.09; P = 0.001]. Restricted cubic spline analysis showed that the risk of all‐cause mortality increased linearly with the TyG index (P for non‐linear = 0.207). Exploratory subgroup analyses revealed that, as a continuous variable, the TyG index was significantly associated with all‐cause mortality in female patients (HR = 1.31, 95% CI: 1.08–1.58, P = 0.029) and older patients (HR = 1.25, 95% CI: 1.1–1.43, P = 0.027).ConclusionsThe TyG index was positively associated with increased all‐cause mortality in hospitalized patients with HF. Subgroup analyses indicated that the TyG index was strongly associated with all‐cause mortality in older and female patients.
Prognostic impact of beta‐blocker use by N‐terminal pro‐brain natriuretic peptide level in acute heart failure patients
Authors: Kim Shin‐Jae , Ann Soe Hee , Park Gyung‐Min , Kim Yong‐Giun , Park Sangwoo , Lee Sang‐Gon 
Published: July 2024

AbstractAimsBoth patients with heart failure (HF) with reduced ejection fraction (HFrEF) and those with HF with preserved ejection fraction (HFpEF) present with elevated N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and have multiple comorbidities; consequently, the prognostic effect of NT‐proBNP according to beta‐blocker (BB) use is unknown.MethodsThis retrospective study evaluated patients admitted for acute HF between January 2012 and December 2017 at Ulsan University Hospital. Clinical, echocardiographic, laboratory and drug prescription data, including BB data, were collected from the hospital database. Information on mortality was collected by reviewing medical records or using national death data.ResultsOf the 472 patients evaluated, 216 (45.8%) and 256 (54.2%) patients were and were not prescribed BB at discharge, respectively. A total of 224 (47.5%) patients died within a median follow‐up duration of 44 months. The Kaplan–Meier analysis showed reduced all‐cause mortality with BB in HFrEF (ejection fraction ≤ 40%) but not in HFpEF (ejection fraction > 40%). In the multivariate Cox regression analysis, transmitral to tissue Doppler imaging, early diastolic velocity ratio (E/E′), NT‐proBNP and BB use were independent predictors of all‐cause mortality in HFrEF. Meanwhile, haemoglobin and NT‐proBNP levels were independent predictors of HFpEF. The NT‐proBNP cut‐off value for determining all‐cause mortality was set to 4800 pg/mL. Among HFrEF patients with NT‐proBNP < 4800 pg/mL, the survival rate was higher for patients with BB use than those with no BB use (log‐rank P < 0.001). However, in the HFpEF group, the survival rate associated with BB use did not differ according to the NT‐proBNP levels. Both HFrEF and HFpEF patients with NT‐proBNP levels of ≥4800 pg/mL presented with multiple comorbidities, including lower body mass index and haemoglobin levels and higher creatinine levels, NT‐proBNP levels and E/E′.ConclusionIn patients with acute HF, BB use is associated with reduced all‐cause mortality in those with HFrEF but not in those with HFpEF. HFrEF patients with NT‐proBNP levels of <4800 pg/mL treated with BB have a higher survival rate than those not treated with BB. However, this benefit is not seen in HFrEF patients with NT‐proBNP levels of ≥4800 pg/mL or in all HFpEF patients, regardless of the NT‐proBNP level. NT‐proBNP levels are elevated in multiple comorbid conditions, and these comorbidities may contribute to the attenuated effects of BB on all‐cause mortality.
Pd/Cu Dual Catalysis for the Oxidative Dearomatization of PyrroleDerivatives: Mechanistic Insights and Biological Studies
Authors: Sau Madan , Dubey Sapana , Roy Shreya , Sahoo Jigyansa , Sahoo Gokarneswar , Sepay Nayim , Chakraborty Sudipta , Samanta Shubhankar , Das Tapas 
Published: July 2024

AbstractHerein we report dearomatization of pyrrole ring followed by rearomatization of cyclohexyl ring to obtain isoindolinone scaffold by a Pd/Cu dual catalysis approach in an atom economic way with moderate to high yield. The expected Pd/Cu catalyzed dual C(sp2)‐H activation via normal catalytic cycle can be override by unusual oxidative dearomatization reaction which has been established by DFT calculation. The biological importance of isoindolinone scaffold insists us to successfully investigate in vitro antileishmanial activity of L.Donovani.
A multi‐institutional feasibility lead‐in trial of lymphatic mapping with SPECT–CT for evaluating contralateral disease in lateralized oropharynx cancer using 99m‐technetium sulfur colloid
Authors: Sarkis Leba Michael , Yao Christopher MKL , Hendler Aaron , Mohan Ravi , Au Michael , Zhang Han , Eskander Antoine , Higgins Kevin , MacNeil Danielle , Tzelnick Sharon , Goldstein David , Hosni Ali , de Almeida John R. 
Published: July 2024

AbstractBackgroundLymphatic mapping with SPECT–CT has been demonstrated to accurately define lymphatic drainage patterns in oropharyngeal cancer but there has yet to be a study demonstrating its feasibility across multiple institutions.MethodsTwelve adult patients with lateralized oropharyngeal carcinoma (T1‐T3) who were planned for definitive or adjuvant radiotherapy without contralateral nodal disease underwent injection of 99‐m technetium sulfur colloid followed by static planar lymphoscintigraphy to verify tracer migration, and SPECT–CT acquired at 30 ± 15 min (optional) and 3 h (±1 h) (mandatory time‐point).ResultsAll 12 patients completed the study with 7/12 patients having the injections performed under local anesthetic and 5 patients requiring general anesthetic. There were no tracer migration failures and there were no serious adverse events or complications encountered. Four out of 12 patients (33%) showed contralateral drainage patterns.ConclusionsLymphatic mapping with SPECT–CT of lateralized oropharyngeal squamous cell carcinoma can be performed safely across multiple institutions.
Planning healthy food environments: An analysis of local government municipal public health and wellbeing policy in regional Victoria
Authors: Dangerfield Fiona , Ball Kylie , Dickson‐Swift Virginia , Thornton Lukar E. 
Published: July 2024

AbstractIssue AddressedWhile there has been an increased focus on how local governments can support the creation of healthy food environments through healthy public policy, little is known about how this is reflected in public health policy in regional areas. The aim of this study was to understand how improvements to the food environment are prioritised, implemented and evaluated by local governments in regional Victoria.MethodsUsing a qualitative descriptive approach, content analysis was undertaken of Municipal Public Health and Wellbeing Plans and Council Plans from 10 regional local governments in Victoria, Australia.ResultsSeventeen policy documents were analysed including 10 Council Plans, 6 Municipal Public Health and Wellbeing Plans and 1 Food Systems Strategy. Findings highlight regional public health and wellbeing plans have very few concrete actions in place to improve food environments.ConclusionThere is an opportunity for Australian regional local governments to include in their public health and wellbeing plans a greater emphasis on supporting healthy food behaviours, and therefore seeking opportunities to improve food environments through clearly aligned priorities, objectives, actions and measures of success.So What?Improving the quality of public health and wellbeing plans can support local government to use policy to drive improvements in food environments leading to improved health and wellbeing for regional communities.
Epidemiological trends and survival of oropharyngeal cancer in a high HPV‐prevalent area: A Danish population‐based study from 2000 to 2020
Authors: Lauritzen Benedicte Bitsch , Grønlund Mathias Waldemar , Jakobsen Kathrine Kronberg , Justesen Marius Meldgaard , Garset‐Zamani Martin , Carlander Amanda‐Louise Fenger , Rasmussen Jacob Høygaard , Bendtsen Simone Kloch , Kiss Katalin , Andersen Gitte , Rosenørn Marie Røsland , Friborg Jeppe , Bentzen Jens Knud Daugaard , Grønhøj Christian , von Buchwald Christian 
Published: July 2024

AbstractDenmark, alongside other Scandinavian countries, the United States, Canada, and the United Kingdom, has high prevalence of human papillomavirus (HPV). Our oropharyngeal squamous cell carcinoma (OPSCC) database includes all diagnosed cases in Eastern Denmark during a period of more than two decades. We investigated the incidence, survival, and recurrence of patients with OPSCC with combined p16‐ and HPV testing covering a consecutive 21‐year period. Age‐adjusted incidence rate (AAIR) per 100,000, survival models, and Cox proportional‐hazards model were employed. Two thousand eight hundred thirty‐four patients were included (57.5% HPV positive (HPV+)/p16 positive (p16+), 33.7% HPV negative (HPV‐)/p16 negative (p16−), 4% HPV+/p16−, and 4.8% HPV−/p16+). The AAIR for all patients increased from 1.8 to 5.1 per 100,000 from 2000 to 2020 linked to an increasing AAIR of HPV+/p16+ OPSCCs from 0.9 to 3.5 per 100,000 from 2000 to 2020. The AAIR for the HPV−/p16− OPSCCs decreased from 1.6 to 1.4 from 2017 to 2020. HPV+/p16+ OPSCCs had a higher 5‐year overall survival (OS) of 79.2% compared to the other subgroups (HPV+/p16− OS: 50.4%; HPV−/p16+ OS: 49.4%; HPV−/p16− OS: 35.1%). The AAIR of the total OPSCC group increased from year 2000 to 2020, driven by a rise in the HPV+/p16+ group. A decreasing incidence rate was observed for the HPV−/p16− OPSCCs from 2017 to 2020. The OS for HPV+/p16+ OPSCCs was significantly higher compared to all other HPV/p16 subgroups. Therefore, we recommend testing for combined HPV and p16 status in patients with OPSCC when selecting patients for clinical trials, especially in case of de‐escalating/escalating.
Beyond passwords: A multi‐factor authentication approach for robust digital security
Authors: Simha.R Keerthan , H K Raghavan , Prabhu Akshatha , Joshi Pallavi 
Published: July 2024

AbstractMulti‐Factor Authentication (MFA) strengthens digital security by necessitating users to verify their identity. It uses various authentication methods like adding an extra layer of protection beyond conventional passwords. Proposed method introduces a novel MFA system that integrates multiple authentication layers, starting with two phase Graphical password with the traditional email‐password and progressing to facial recognition using Convolutional Neural Networks (CNN) and Quick response (QR) code authentication. To prove the robustness of our method, we are considering some test cases and few performance metrics like delay, accuracy, etc. The results are derived for False positive rates, complexity. The success rate is observed to be more than 93% for the proposed model.