bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous Coronary Intervention Versus Optimal Medical Therapy for Prevention of Spontaneous Myocardial Infarction in Subjects With Stable Ischemic Heart Disease
Authors: Bangalore Sripal , Pursnani Seema , Kumar Sunil , Bagos Pantelis G. 
Published: January 2013

Background—
Contemporary studies have shown that spontaneous but not procedural myocardial infarction (MI) is related to subsequent mortality. Whether percutaneous coronary intervention (PCI) reduces spontaneous (nonprocedural) MI is unknown.

Methods and Results—
PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for randomized clinical trials until October 2012 comparing PCI with optimal medical therapy (OMT) for stable ischemic heart disease and reporting MI outcomes: spontaneous nonprocedural MI, procedural MI, and all MI, including procedure-related MI. Given the varying length of follow-up between trials, a mixed-effect Poisson regression meta-analysis was used. From 12 randomized clinical trials with 37 548 patient-years of follow-up, PCI compared with OMT alone was associated with a significantly lower incident rate ratio (IRR) for spontaneous nonprocedural MI (IRR=0.76; 95% confidence interval [CI], 0.58–0.99) at the risk of a higher rate of procedural MI (IRR=4.11; 95% CI, 2.53–6.88) without any difference in the risk of all MI (IRR=0.96; 95% CI, 0.74–1.21). The point estimate for PCI versus OMT for all-cause mortality (IRR=0.88; 95% CI, 0.75–1.03) and cardiovascular mortality (IRR=0.70; 95% CI, 0.44–1.09) paralleled that for spontaneous nonprocedural MI (but not procedural or all nonfatal MI), although these were not statistically significant.

Conclusions—
PCI compared with OMT reduced spontaneous MI at the risk of procedural MI without any difference in all MI. Consistent with prior studies showing that spontaneous MI but not procedural MI is related to subsequent mortality, in the present report the point estimate for reduced mortality with PCI compared with OMT paralleled the prevention of spontaneous MI with PCI. Further studies are needed to determine whether these associations are causal.
Traces of marine nematodes from 470 million years old Early Ordovician rocks in China
Authors: Baliński Andrzej , Sun Yuanlin , Dzik Jerzy 
Published: January 2013

Cylindrical, mostly horizontal, burrows of 20-60 μm diam. and sinusoidal course, found in the middle part of the Early Ordovician (early Floian) Fenxiang Formation in the Hubei Province of China, represent the oldest record of activity by marine nematodes, preceding known nematode body fossils by 70 million years. The burrows are filled with secondarily oxidised pyrite framboids and clay mineral flakes, indicating low oxygen content in the mud and proving that the animals lined their burrows with organic matter, being bacteriovores and mud-eaters. The marine bottom environment enabling such a mode of life originated no earlier than the mid Early Cambrian (approximately 535 million years ago) owing to peristaltic bioturbation, mostly by nemathelminthans of priapulid affinities. Before the so-called ‘Agricultural Revolution’, the bottoms of shallow seas were covered with microbial mats preventing within-sediment animal life. This event imposes the lower time limit on the possible date of origin of nematodes.
Désert et ville dans la Correspondance de saint Jérôme
Authors: Canellis Aline 
Published: January 2013

Abstract
Jerome travelled widely in East and West. Being a vir trilinguis, who was fluent in Greek and Latin and also knew Hebrew (and a few Syrian words), he was familiar with life in the desert and the cities. His letters make clear what living in the desert meant for him, and the same is true for life in the contemporary towns and cities. Thoroughly educated in classical and biblical culture, he pictures the desert and the city in a rather peculiar manner, by placing them in the history of Rome and Israel with the addition of exegetical interpretation.
Description of Chistyakovella insolita gen. nov., sp. nov., and redescription of the type species of Diplobodes, D. kanekoi Aoki, 1958 (Acari: Oribatida: Carabodidae)
Authors: ERMILOV SERGEY G. , AOKI JUN-ICHI , ANICHKIN ALEXANDER E. 
Published: January 2013

A new oribatid mite genus, Chistyakovella gen. nov. (Carabodidae), with type species C. insolita sp. nov., is proposed and described from Southern Vietnam. It is clearly distinguished from other carabodid genera by the lamellae, which are touching medially. The new genus is most similar morphologically to Gibbicepheus Balogh, 1958 and Diplobodes Aoki, 1958, however it can be clearly distinguished from both genera by the position of interlamellar setae and the number of notogastral setae on the humeral regions of the notogaster. The type species of the genus Diplobodes, D. kanekoi Aoki, 1958, is redescribed from Japan. An identification key to known species of Diplobodes is presented.
Records of the hermit crab genus Pagurixus Melin, 1939 (Crustacea: Decapoda: Anomura: Paguridae) from Europa Island, western Indian Ocean, with descriptions of two new species
Authors: KOMAI TOMOYUKI , POUPIN JOSEPH 
Published: January 2013

Three species of the pagurid hermit crab genus Pagurixus Melin, 1939, are reported from Europa Island in the Mozambique Strait, western Indian Ocean: P. haigae Komai & Osawa, 2007, P. annulus n. sp., and P. europa n. sp. Pagurixus haigae is recorded from the western Indian Ocean for the first time. Pagurixus annulus n. sp. and P. europa n. sp. are referred to the P. boninensis (Melin, 1939) species group and P. anceps (Forest, 1954) group, respectively. Diagnostic characters of these two new species are discussed.
A Spatial Filter Approach to Evaluating the Role of Convection on the Evolution of a Mesoscale Vortex
Authors: Creighton Glenn A. , Hart Robert E. , Cunningham Philip 
Published: January 2013

Abstract
A new spatial filter is proposed that exploits a spectral gap in power between the convective scale and the system (“vortex”) scale during tropical cyclone (TC) genesis simulations. Using this spatial separation, this study analyzes idealized three-dimensional numerical simulations of deep moist convection in the presence of a symmetric midlevel vortex to quantify and understand the energy cascade between the objectively defined convective scale and system scale during the early stages of tropical cyclogenesis. The simulations neglect surface momentum, heat, and moisture fluxes to focus on generation and enhancement of vorticity within the interior to more completely close off the energy budget and to be consistent for comparison with prior benchmark studies of modeled TC genesis.
The primary contribution to system-scale intensification comes from the convergence of convective-scale vorticity that is supplied by vortical hot towers (VHTs). They contribute more than the convergence of system-scale vorticity to the spinup of vorticity in these simulations by an order of magnitude. Analysis of the change of circulation with time shows an initial strengthening of the surface vortex, closely followed by a growth of the mid- to upper-level circulation. This evolution precludes any possibility of a stratiform precipitation–induced top-down mechanism as the primary contributor to system-scale spinup in this simulation. Instead, an upscale cascade of rotational kinetic energy during vortex mergers is responsible for spinup of the simulated mesoscale vortex. The spatial filter employed herein offers an alternative approach to the traditional symmetry–asymmetry paradigm, acknowledges the highly asymmetric evolution of the system-scale vortex itself, and may prove useful to future studies on TC genesis.
Coherence of Western Boundary Pressure at the RAPID WAVE Array: Boundary Wave Adjustments or Deep Western Boundary Current Advection?
Authors: Elipot Shane , Hughes Chris , Olhede Sofia , Toole John 
Published: January 2013

Abstract
This study investigates the coherence between ocean bottom pressure signals at the Rapid Climate Change programme (RAPID) West Atlantic Variability Experiment (WAVE) array on the western North Atlantic continental slope, including the Woods Hole Oceanographic Institution Line W. Highly coherent pressure signals propagate southwestward along the slope, at speeds in excess of 128 m s−1, consistent with expectations of barotropic Kelvin-like waves. Coherent signals are also evidenced in the smaller pressure differences relative to 1000-m depth, which are expected to be associated with depth-dependent basinwide meridional transport variations or an overturning circulation. These signals are coherent and almost in phase for all time scales from 3.6 years down to 3 months. Coherence is still seen at shorter time scales for which group delay estimates are consistent with a propagation speed of about 1 m s−1 over 990 km of continental slope but with large error bounds on the speed. This is roughly consistent with expectations for propagation of coastally trapped waves, though somewhat slower than expected. A comparison with both Eulerian currents and Lagrangian float measurements shows that the coherence is inconsistent with a propagation of signals by advection, except possibly on time scales longer than 6 months.
Weight Gain after Adenotonsillectomy Is More Common in Young Children
Authors: Smith David F. , Vikani Ami R. , Benke James R. , Boss Emily F. , Ishman Stacey L. 
Published: January 2013

ObjectiveAdenotonsillectomy (TA), performed for obstructive sleep apnea (OSA) or recurrent tonsillitis (RT), has been associated with weight gain after surgery. The objective of this study was to look at a large population of children undergoing TA and the demographic factors that contribute to postoperative weight gain.Study DesignCase series with retrospective chart review.SettingTertiary, urban academic care center.Subjects and MethodsChildren undergoing TA at an academic center between 2008 and 2011 were included in this study. Demographic data (age, gender, race), OSA disease severity, preoperative and 3‐ to 6‐month postoperative normalized body mass index (BMI; z‐scores), and changes in z‐scores were compared.ResultsComplete weight data after TA were available for 115 children, 85 of whom underwent surgery for OSA. Mean age (7.2 ± 4.3 vs 7.3 ± 4.4 years, P =. 955) and gender distribution (38% female vs 50% male; P =. 323) were similar for the OSA and RT groups. However, children with OSA were more likely to be black (60% vs 33%) than RT patients (P =. 026). Overall, the preoperative BMI z‐score increased from 0.98 ± 1.50 to 1.21 ± 1.25 (P =. 0009) with no difference by surgical indication (P =. 58). Multiple linear regression analysis demonstrated that only age was significantly, and negatively, associated with changes in BMI z‐scores (P =. 015).ConclusionsSimilar to previous studies, children had weight gain after TA. In this analysis, younger age (≤6 years) was a significant predictor of postoperative weight gain. Future research should prospectively evaluate the association between weight gain and demographic factors in children undergoing TA, with special attention to the relationship with age.
End‐Organ Testing for Allergic Rhinitis with Fungi Is Poorly Correlated with Fungal Sensitivity
Authors: Agarwal Garima , Hernandez David , Citardi Martin J. , Fakhri Samer , Luong Amber 
Published: January 2013

ObjectiveTo evaluate optical rhinometry (ORM) using nasal provocation testing (NPT) as an objective tool to diagnose fungal allergic rhinitis (AR).Study DesignProspective.SettingTertiary academic center.MethodsWe prospectively enrolled healthy controls (HCs) and subjects with a clinical history of AR and positive skin prick test to Alternaria or Aspergillus antigens. Baseline measurements with an optical and acoustic rhinometer (AcR) were taken, and all subjects underwent NPT with increasing concentrations of Alternaria and then Aspergillus in each nasal cavity. Optical density (OD), nasal mean cross‐sectional area (MCA), visual analog scale (VAS), and nasal allergen provocation scale (NAP) were measured after each provocation. A NAP score ≥3 was considered positive. Receiver operating characteristic (ROC) curve analysis was performed on measured parameters.ResultsEleven HCs and 11 AR subjects were enrolled. Of the 8 AR patients with an Alternaria‐positive skin test, 50% had a positive NAP score (4/8) vs 0% in HCs (0/11, P =. 01). Although VAS could differentiate Alternaria‐sensitive patients from controls, change in OD and MCA could not. Of the 7 skin test–positive Aspergillus patients, 43% had a positive NAP score (3/7) vs 0% in HCs (0/11, P =. 02). The VAS and change in OD and MCA did not differentiate Aspergillus‐sensitive patients from controls.ConclusionIn this study, fungal antigens caused irritation but did not elicit early phase changes in nasal patency or blood flow in fungal‐sensitive AR patients. The poor correlation of skin testing and objective nasal response to fungi argues against a pure IgE‐mediated immune response in the nasal cavity.
Essentials of Th17 cell commitment and plasticity
Authors: Muranski Pawel , Restifo Nicholas P. 
Published: January 2013

AbstractCD4+ T helper (Th) cells exist in a variety of epigenetic states that determine their function, phenotype, and capacity for persistence. These polarization states include Th1, Th2, Th17, and Foxp3+ T regulatory cells, as well as the more recently described T follicular helper, Th9, and Th22 cells. Th17 cells express the master transcriptional regulator retinoic acid–related orphan receptor γ thymus and produce canonical interleukin (IL)-17A and IL-17F cytokines. Th17 cells display a great degree of context-dependent plasticity, as they are capable of acquiring functional characteristics of Th1 cells. This late plasticity may contribute to the protection against microbes, plays a role in the development of autoimmunity, and is necessary for antitumor activity of Th17 cells in adoptive cell transfer therapy models. Moreover, plasticity of this subset is associated with higher in vivo survival and self-renewal capacity and less senescence than Th1 polarized cells, which have less plasticity and more phenotypic stability. New findings indicate that subset polarization of CD4+ T cells not only induces characteristic patterns of surface markers and cytokine production but also has a maturational aspect that affects a cell’s ability to survive, respond to secondary stimulation, and form long-term immune memory.
Significance of FAB subclassification of “acute myeloid leukemia, NOS” in the 2008 WHO classification: analysis of 5848 newly diagnosed patients
Authors: Walter Roland B. , Othus Megan , Burnett Alan K. , Löwenberg Bob , Kantarjian Hagop M. , Ossenkoppele Gert J. , Hills Robert K. , van Montfort Kees G. M. , Ravandi Farhad , Evans Anna , Pierce Sherry R. , Appelbaum Frederick R. , Estey Elihu H. 
Published: January 2013

Key Points
The FAB type (ie, M0-M7) does not provide prognostic information for cases of “AML, NOS” in the 2008 WHO classification.
Transcriptional profiling of the Arabidopsis abscission mutant hae hsl2by RNA-Seq
Authors: Niederhuth Chad E , Patharkar O Rahul , Walker John C 
Published: January 2013

AbstractBackgroundAbscission is a mechanism by which plants shed entire organs in response to both developmental and environmental signals.Arabidopsis thaliana, in which only the floral organs abscise, has been used extensively to study the genetic, molecular and cellular processes controlling abscission. Abscission in Arabidopsis requires two genes that encode functionally redundant receptor-like protein kinases,HAESA(HAE) andHAESA-LIKE 2(HSL2). Doublehae hsl2mutant plants fail to abscise their floral organs at any stage of floral development and maturation.ResultsUsing RNA-Seq, we compare the transcriptomes of wild-type andhae hsl2stage 15 flowers, using the floral receptacle which is enriched for abscission zone cells. 2034 genes were differentially expressed with a False Discovery Rate adjusted p < 0.05, of which 349 had two fold or greater change in expression. Differentially expressed genes were enriched for hydrolytic, cell wall modifying, and defense related genes. Testing several of the differentially expressed genes inINFLORESCENCE DEFICIENT IN ABSCISSION(ida) mutants shows that many of the same genes are co-regulated by IDA and HAE HSL2 and support the role of IDA in the HAE and HSL2 signaling pathway. Comparison to microarray data from stamen abscission zones show distinct patterns of expression of genes that are dependent onHAE HSL2and revealHAE HSL2- independent pathways.ConclusionHAE HSL2-dependent andHAE HSL2-independent changes in genes expression are required for abscission.HAEandHSL2affect the expression of cell wall modifying and defense related genes necessary for abscission. TheHAE HSL2-independent genes also appear to have roles in abscission and additionally are involved in processes such as hormonal signaling, senescence and callose deposition.
Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation
Authors: Sirota Jeffrey C , Walcher Angela , Faubel Sarah , Jani Alkesh , McFann Kim , Devarajan Prasad , Davis Connie L , Edelstein Charles L 
Published: January 2013

Abstract

Background
AKI is common following liver transplantation and is associated with significant morbidity and mortality. Biomarkers of AKI have not been well established in this setting but are needed to help guide patient care and facilitate development of novel therapeutics.

Methods
Serum creatinine, cystatin C, IL-6, and IL-8 and urine IL-18, NGAL, IL-6, and IL-8 were measured before and within 24 hours after liver transplantation in 40 patients. AKI was defined as a ≥50% sustained increase in creatinine above pre-operative values occurring within 24 hours of transplantation and persisting for at least 24 hours.

Results
Seven patients met criteria for AKI (17.5%), with mean creatinines of 0.81 mg/dL pre-operatively and 1.75 mg/dL post-operatively. While pre-operative biomarker levels in patients with AKI were similar to those in patients without AKI, differences were seen between the groups with regard to median post-operative serum IL-8 (pg/mL) (242.48 vs. 82.37, p = 0.0463) and urine NGAL (ng/mL) (386.86 vs. 24.31, p = 0.0039), IL-6 (pg/mL) (52 vs. 7.29, p=0.0532), IL-8 (pg/mL) (14.3 vs. 0, p = 0.0224), and IL-18 (pg/mL) (883.09 vs. 0, p = 0.0449). The areas under receiver operating characteristic (ROC) curves were 0.749 for urine IL-18, 0.833 for urine NGAL, 0.745 for urine IL-6, 0.682 for serum IL-6, 0.773 for urine IL-8, and 0.742 for serum IL-8. Post-operative cystatin C was not significantly different between AKI and no AKI groups.

Conclusion
Serum IL-8 and urine IL-18, NGAL, IL-6, and IL-8 are elevated in AKI within the first 24 hours following liver transplantation.
A greater number of somatic pain sites is associated with poor mental health in adolescents: a cross-sectional study
Authors: Ando Shuntaro , Yamasaki Syudo , Shimodera Shinji , Sasaki Tsukasa , Oshima Norihito , Furukawa Toshi A , Asukai Nozomu , Kasai Kiyoto , Mino Yoshio , Inoue Shimpei , Okazaki Yuji , Nishida Atsushi 
Published: January 2013

Abstract

Background
Identifying indicators of poor mental health during adolescence is a significant public health issue. Previous studies which suggested an association between the number of somatic pains and depression have mainly focused on adults or have employed samples with a narrow age range. To date, results from previous studies have been inconsistent regarding the association between somatic pain and academic impairment. Therefore, the main aims of the present study were to 1) investigate the association between the number of somatic pain sites and poor mental health using a community sample of adolescents aged 12 to 18 years and employing a simple method of assessment, and 2) examine the association between the number of somatic pain sites and perceived academic impairment.

Methods
Data analysis was conducted using a large cross-sectional survey of adolescents in grades 7 to 12. The one-month prevalence rates for three sites of somatic pain including head, neck and shoulders, and abdomen were examined. Poor mental health was evaluated using the General Health Questionnaire, and perceived academic impairment was measured using a self-report questionnaire.

Results
A total of 18,104 adolescents participated in the survey. A greater number of pain sites was associated with poor mental health, and this association was consistent across age and gender. There was no difference in effect on mental health between any of the pain sites. Although there was an association between the number of somatic pain sites and perceived academic impairment, the results suggested that the association was mediated by poor mental health.

Conclusions
Simple reporting methods for assessing the number of pain sites may be a feasible indicator of poor mental health in adolescents. Professionals working with adolescents should consider the possibility of poor mental health, especially when students report multiple somatic pains.
Are religious beliefs and practices of Buddhism associated with disability and salivary cortisol in office workers with chronic low back pain?
Authors: Sooksawat Annop , Janwantanakul Prawit , Tencomnao Tewin , Pensri Praneet 
Published: January 2013

Abstract

Background
Low back pain (LBP) is common among office workers. A number of studies have established a relationship between Christianity and physical and mental health outcomes among chronic pain patients. The purpose of this study was to examine the relationship between the religious beliefs and practices of Buddhism and disability and psychological stress in office workers with chronic LBP.

Methods
A cross-sectional survey was conducted with a self-administered questionnaire delivered by hand to 463 office workers with chronic LBP. Saliva samples were collected from a randomly selected sub-sample of respondents (n=96). Disability due to LBP was assessed using the Roland-Morris Disability Questionnaire and psychological stress was assessed based on salivary cortisol. Two hierarchical regression models were built to determine how much variance in disability and psychological stress could be explained by religious beliefs and practices of Buddhism variables after controlling for potential confounder variables.

Results
Only 6% of variance in psychological stress was accounted for by the religious beliefs and practices of Buddhism. Those with high religiousness experienced lower psychological stress. No association between the religious beliefs and practices of Buddhism and disability level was found. Depressive symptoms were attributed to both psychological stress and disability status in our study population.

Conclusions
The findings suggest that, although being religious may improve the psychological condition in workers with chronic LBP, its effect is insufficient to reduce disability due to illness. Further research should examine the role of depression as a mediator of the effect of psychological stress on disability in patients with chronic LBP.