bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant properties of xanthones from Calophyllum brasiliense: prevention of oxidative damage induced by FeSO4
Authors: Blanco-Ayala Tonali , Lugo-Huitrón Rafael , Serrano-López Elizabeth M , Reyes-Chilpa Ricardo , Rangel-López Edgar , Pineda Benjamín , Medina-Campos Omar Noel , Sánchez-Chapul Laura , Pinzón Enrique , Cristina Trejo-Solis , Silva-Adaya Daniela , Pedraza-Chaverrí José , Ríos Camilo , de la Cruz Verónica Pérez , Torres-Ramos Mónica 
Published: October 2013

Abstract

Background
Reactive oxygen species (ROS) are important mediators in a number of degenerative diseases. Oxidative stress refers to the imbalance between the production of ROS and the ability to scavenge these species through endogenous antioxidant systems. Since antioxidants can inhibit oxidative processes, it becomes relevant to describe natural compounds with antioxidant properties which may be designed as therapies to decrease oxidative damage and stimulate endogenous cytoprotective systems. The present study tested the protective effect of two xanthones isolated from the heartwood of Calophyllum brasilienses against FeSO4-induced toxicity.

Methods
Through combinatory chemistry assays, we evaluated the superoxide (O2
●—), hydroxyl radical (OH●), hydrogen peroxide (H2O2) and peroxynitrite (ONOO—) scavenging capacity of jacareubin (xanthone III) and 2-(3,3-dimethylallyl)-1,3,5,6-tetrahydroxyxanthone (xanthone V). The effect of these xanthones on murine DNA and bovine serum albumin degradation induced by an OH• generator system was also evaluated. Additionally, we investigated the effect of these xanthones on ROS production, lipid peroxidation and glutathione reductase (GR) activity in FeSO4-exposed brain, liver and lung rat homogenates.

Results
Xanthone V exhibited a better scavenging capacity for O2
●—, ONOO- and OH● than xanthone III, although both xanthones were unable to trap H2O2. Additionally, xanthones III and V prevented the albumin and DNA degradation induced by the OH● generator system. Lipid peroxidation and ROS production evoked by FeSO4 were decreased by both xanthones in all tissues tested. Xanthones III and V also prevented the GR activity depletion induced by pro-oxidant activity only in the brain.

Conclusions
Altogether, the collected evidence suggests that xanthones can play a role as potential agents to attenuate the oxidative damage produced by different pro-oxidants.
Feasibility intervention trial of two types of improved cookstoves in three resource-limited settings: study protocol for a randomized controlled trial
Authors: Klasen Elizabeth , Miranda J Jaime , Khatry Subarna , Menya Diana , Gilman Robert H , Tielsch James M , Kennedy Caitlin , Dreibelbis Robert , Naithani Neha , Kimaiyo Sylvester , Chiang Marilu , Carter E Jane , Sherman Charles B , Breysse Patrick N , Checkley William ,   COCINAS Trial Working Group
Published: October 2013

AbstractBackgroundExposure to biomass fuel smoke is one of the leading risk factors for disease burden worldwide. International campaigns are currently promoting the widespread adoption of improved cookstoves in resource-limited settings, yet little is known about the cultural and social barriers to successful improved cookstove adoption and how these barriers affect environmental exposures and health outcomes.DesignWe plan to conduct a one-year crossover, feasibility intervention trial in three resource-limited settings (Kenya, Nepal and Peru). We will enroll 40 to 46 female primary cooks aged 20 to 49 years in each site (total 120 to 138).MethodsAt baseline, we will collect information on sociodemographic characteristics and cooking practices, and measure respiratory health and blood pressure for all participating women. An initial observational period of four months while households use their traditional, open-fire design cookstoves will take place prior to randomization. All participants will then be randomized to receive one of two types of improved, ventilated cookstoves with a chimney: a commercially-constructed cookstove (Envirofit G3300/G3355) or a locally-constructed cookstove. After four months of observation, participants will crossover and receive the other improved cookstove design and be followed for another four months. During each of the three four-month study periods, we will collect monthly information on self-reported respiratory symptoms, cooking practices, compliance with cookstove use (intervention periods only), and measure peak expiratory flow, forced expiratory volume at 1 second, exhaled carbon monoxide and blood pressure. We will also measure pulmonary function testing in the women participants and 24-hour kitchen particulate matter and carbon monoxide levels at least once per period.DiscussionFindings from this study will help us better understand the behavioral, biological, and environmental changes that occur with a cookstove intervention. If this trial indicates that reducing indoor air pollution is feasible and effective in resource-limited settings like Peru, Kenya and Nepal, trials and programs to modify the open burning of biomass fuels by installation of low-cost ventilated cookstoves could significantly reduce the burden of illness and death worldwide.Trial registrationClinicalTrials.govNCT01686867
Is switching from brand name to generic formulations of phenobarbital associated with loss of antiepileptic efficacy?: a pharmacokinetic study with two oral formulations (Luminal® vet, Phenoleptil®) in dogs
Authors: Bankstahl Marion , Bankstahl Jens P , Löscher Wolfgang 
Published: October 2013

Abstract

Background
In human medicine, adverse outcomes associated with switching between bioequivalent brand name and generic antiepileptic drug products is a subject of concern among clinicians. In veterinary medicine, epilepsy in dogs is usually treated with phenobarbital, either with the standard brand name formulation Luminal® or the veterinary products Luminal® vet and the generic formulation Phenoleptil®. Luminal® and Luminal® vet are identical 100 mg tablet formulations, while Phenoleptil® is available in the form of 12.5 and 50 mg tablets. Following approval of Phenoleptil® for treatment of canine epilepsy, it was repeatedly reported by clinicians and dog owners that switching from Luminal® (human tablets) to Phenoleptil® in epileptic dogs, which were controlled by treatment with Luminal®, induced recurrence of seizures. In the present study, we compared bioavailability of phenobarbital after single dose administration of Luminal® vet vs. Phenoleptil® with a crossover design in 8 healthy Beagle dogs. Both drugs were administered at a dose of 100 mg/dog, resulting in 8 mg/kg phenobarbital on average.

Results
Peak plasma concentrations (Cmax) following Luminal® vet vs. Phenoleptil® were about the same in most dogs (10.9 ± 0.92 vs. 10.5 ± 0.77 μg/ml), and only one dog showed noticeable lower concentrations after Phenoleptil® vs. Luminal® vet. Elimination half-life was about 50 h (50.3 ± 3.1 vs. 52.9 ± 2.8 h) without differences between the formulations. The relative bioavailability of the two products (Phenoleptil® vs. Luminal® vet.) was 0.98 ± 0.031, indicating that both formulations resulted in about the same bioavailability.

Conclusions
Overall, the two formulations did not differ significantly with respect to pharmacokinetic parameters when mean group parameters were compared. Thus, the reasons for the anecdotal reports, if true, that switching from the brand to the generic formulation of phenobarbital may lead to recurrence of seizures are obviously not related to a generally lower bioavailability of the generic formulation, although single dogs may exhibit lower plasma levels after the generic formulation that could be clinically meaningful.
Intrathoracic giant pleural lipoma: case report and review of the literature
Authors: Chen Ming , Yang Jun , Zhu Lei , Zhao Heng 
Published: October 2013

Abstract
This report describes a giant pleural lipoma that arose from the pleura of the 7th anterior intercostal space and occupied approximately 75% of the right pleural cavity in a 49-year-old woman. The tumor was completely excised by right thoracotomy. The complete histopathological investigation showed pleural lipoma, and we made a review of literature.
Immunophenotypic Characterization of T-Cell Prolymphocytic Leukemia
Authors: Chen Xueyan , Cherian Sindhu 
Published: October 2013

Abstract

Objectives:
To review clinical data, cytogenetic findings, and flow cytometric analysis in 20 patients with T-cell prolymphocytic leukemia (T-PLL), a rare, aggressive, mature T-cell leukemia with poor prognosis and short survival.

Methods:
Using multiparameter flow cytometry with a large combination of antibodies, we summarize the immunophenotypic features of T-PLL, including unusual immunophenotypic variants, and illustrate immunophenotypic clues that may help distinguish this entity from other T-cell malignancies.

Results:
By flow cytometry, T-PLL is characterized by a postthymic mature T-cell immunophenotype with a variety of abnormalities that usually allow distinction from other mature T-cell leukemias.

Conclusions:
Although definitive diagnosis of T-PLL requires a systemic approach with integration of clinical data, morphology, immunophenotype, cytogenetics/fluorescence in situ hybridization, and molecular features, our results indicate immunophenotyping by multiparameter flow cytometry greatly facilitates diagnosis and assists with subclassification of this mature T-cell leukemia.
Postoperative ischemic changes following brain metastasis resection as measured by diffusion-weighted magnetic resonance imaging
Authors: Gempt Jens , Gerhardt Julia , Toth Vivien , Hüttinger Stefanie , Ryang Yu-Mi , Wostrack Maria , Krieg Sandro M. , Meyer Bernhard , Förschler Annette , Ringel Florian 
Published: October 2013

Object
Brain metastases occur in 10% to 40% of patients harboring cancer. In cases of neurosurgical metastasis resection, all postoperative neurological deterioration should be avoided. Reasons for postoperative deficits can be direct tissue damage due to resection, hemorrhage, venous congestive infarcts, or arterial ischemic events leading to tissue infarction. The aim of this study was to evaluate whether postoperative ischemic infarctions occur in surgery for brain metastasis and to determine their influence on new postoperative neurological deficits.

Methods
Patients who underwent resection of brain metastases and had preoperative and early postoperative (within 48 hours) MRI scans, including diffusion-weighted imaging sequences and apparent diffusion coefficient maps, between January 2009 and May 2012 were included in this study. Clinical and histopathological data (histopathological results, pre- and postoperative neurological status, and previous tumor-specific therapy) were recorded.

Results
One hundred twenty-two patients (56 male, 66 female) who underwent resection of brain metastases were included. The patients' mean age was 60 years (range 21–89 years). The mean time span from initial tumor diagnosis to resection of brain metastasis was 44 months (range 0–338 months). The mean preoperative Karnofsky Performance Status was 80% (exact mean 76% ± 17% [SD]), and the mean postoperative value was 80% (exact mean 78% ± 17%). Twelve (9.8%) of the 122 patients had postoperative permanent worsening of a neurological deficit or a new permanent neurological deficit; 44 (36.1%) of the 122 patients had postoperative ischemic lesions. When comparing patients with and without previous brain irradiation, 53.8% of patients with previous brain irradiation had ischemic lesions on postoperative imaging compared with 31.3% of patients without previous brain irradiation (p = 0.033). There was a significant association between ischemia and postoperative neurological status deterioration (transient or permanent); 13 (29.5%) of 44 patients with ischemic lesions had deterioration of their neurological status compared with 7 (9%) of the 78 patients who did not have ischemic lesions (p = 0.003).

Conclusions
This study demonstrates a high prevalence of vascular incidents in patients undergoing resection for metastatic brain disease. Patients harboring postoperative ischemic lesions detected by MRI have a higher rate of neurological deficits (transient or permanent). Patients who had previous irradiation therapy are at higher risk of developing postoperative ischemic lesions. A large number of postoperative neurological deficits are caused by ischemic incidents.
Health, Disability, Psychological Well-Being, and Depressive Symptoms among Older African American Women
Authors: Nguyen Ann W. , Taylor Robert Joseph , Peterson Tina , Chatters Linda M. 
Published: October 2013

Abstract
This study examines the demographic correlates of psychological well-being (i.e., happiness and life satisfaction) and mental health (i.e., depressive symptoms and serious psychological distress) among older African American women. Additionally, the relationships between self-rated physical and oral health and disability and psychological well-being and mental health are explored. Analyses are based on a nationally representative sample of older African American women from the National Survey of American Life. Results indicate that psychological well-being (i.e., life satisfaction and happiness) and mental health (i.e., depressive symptoms and serious psychological distress) are associated with specific demographic factors. In addition, self-rated health and limited mobility due to disability exerted significant influences on psychological well-being, depressive symptoms, and psychological distress. Findings are discussed in relation to prior research on demographic and health factors and their unique associations with well-being and mental status among older African American women.
High‐Efficiency Deep Red Electroluminescence via a Spiro‐Based Pure Hydrogen Carbon Host
Authors: Yu You‐Jun , Qu Zhi‐Hao , Ding Ling‐Yi , Wang Xue‐Qi , Meng Xin‐Yue , Li Meng‐Tian , Zhou Dong‐Ying , Jiang Zuo‐Quan , Liao Liang‐Sheng 
Published: July 2024

AbstractDeep‐red and near‐infrared emitters with twisted donor–acceptor (D–A) structures often exhibit suboptimal performance in organic light‐emitting diodes (OLEDs) due to constraints imposed by the energy gap law. In this work, a pure hydrogen carbon (PHC) host material named SBF‐DTP is purposefully tailored for deep‐red OLEDs. The excellent capacity of SBF‐DTP to support D–A type DR emitters effectively arises from its distinctive attributes: localized excitation states, 3D configuration, and low polarity. When employing SBF‐DTP as the host for the fluorescence emitter DCPA‐TPA and the thermally activated delayed fluorescence emitter APDC‐DTPA, doped films exhibit substantially enhanced photoluminescence quantum yields. This improvement leads to high‐efficiency OLEDs with external quantum efficiencies of 5.47% for DCPA‐TPA and 20.03% for APDC‐DTPA, respectively, which is about twice as high as the initial reports. This findings underscore the paramount significance of developing efficient host materials in the pursuit of high‐performance deep red and even near‐infrared OLEDs.
Recent Advances and Prospects of Chalcogenide Cathodes for Rechargeable Magnesium Batteries
Authors: Liu Yuehao , Qu Baihua , Li Shengyang , Lian Xiaojin , Luo Yuanyi , Shen Xing , Xu Chaohe , Wang Jingfeng , Pan Fusheng 
Published: July 2024

AbstractRechargeable magnesium batteries (RMBs) have garnered considerable interest from researchers and industries owing to their abundant resources, cost‐effectiveness, impressive energy density, and safety features, positioning them as a compelling technology for sustainable energy. Chalcogenides, with their high electrochemical activity and low charge density, facilitate the diffusion and migration of Mg2+. “Soft” anionic lattices, such as S or Se, weaken the Coulombic attraction between the crystal structure and Mg2+, thereby promoting the accelerated diffusion and reversible intercalation of Mg2+. Consequently, they are highly regarded as promising cathode materials for RMBs. However, their real‐world implementation is hindered by challenges including low conductivity, formidable ion diffusion barriers, and insufficient cyclic stability. In this study, chalcogenides are categorized into intercalation‐ and conversion‐types based on the Mg2+ storage mechanism, providing a comprehensive examination and taxonomy of various modification approaches aimed at enhancing the electrochemical performance of chalcogenides. These approaches include intercalation engineering, phase engineering, defect engineering, doping effects, and nanostructure engineering. Furthermore, specific modification strategies for certain chalcogenide cathode materials are summarized and discussed. Finally, the key points of optimization strategies for chalcogenide cathode materials are summarized, along with the proposed future breakthrough directions.
Molecule Doping of Atomically Dispersed Cu–Au Alloy for Enhancing Electroreduction of CO to C2+ Products
Authors: Sun Qian , Tan Xin , Jia Chen , Rong Chengli , Wang Shuhao , Han Chen , Xiao Yang , Qi Huiqian , Smith Sean C. , Zhao Chuan 
Published: July 2024

AbstractElectrocatalytic carbon monoxide reduction (CORR) is effective in achieving renewable synthesis of valuable C2+ species from CO. However, the production of C2+ species is challenged by low activity and selectivity. Here, the surface of the atomically dispersed Cu–Au alloy is functionalized with aromatic heterocycle, thiadiazole derivate (N2SN), to enhance the conversion of CO into C2+ species with acetate as the main product. The N2SN functional groups with electron withdrawing property can alternate the oxidization state of copper, as confirmed by XPS and XAS, thus orienting the CORR pathway to the formation of C2+/acetate. In situ Raman reveals that the N2SN treated sample exhibits stronger signal of *CO intermediate for further dimerization and the C–C–O intermediate relates to acetate formation. Theoretical calculation demonstrates the N2SN molecule doping contributes to lowered energy barrier for C–C coupling, improved activity and selectivity to CORR, and suppressed hydrogen evolution reaction. High Faradaic efficiency (FEC2+, 89%), partial current density (jC2+, 397 mA cm−2), and energy efficiency for C2+ species (EEC2+, 24%) and total current density (jtotal, up to 1000 mA cm−2) are achieved in membrane electrode assembly (MEA), surpassing most of the reported catalysts for total C2+ products.
A mechanically Robust, Damping, and High‐Temperature Tolerant Ion‐Conductive Elastomer for Noise‐Free Flexible Electronics
Authors: Shen Shengtao , Du Zehang , Zhou Piaopiao , Zou Zhigang , Lyu Xiaolin 
Published: July 2024

AbstractIon‐conductive elastomers capable of damping can significantly mitigate the interference caused by mechanical noise during data acquisition in wearable and biomedical devices. However, currently available damping elastomers often lack robust mechanical properties and have a narrow temperature range for effective damping. Here, precise modulation of weak to strong ion‐dipole interactions plays a crucial role in bolstering network stability and tuning the relaxation behavior of supramolecular ion‐conductive elastomers (SICEs). The SICEs exhibit impressive mechanical properties, including a modulus of 13.2 MPa, a toughness of 65.6 MJ m−3, and a fracture energy of 74.9 kJ m−2. Additionally, they demonstrate remarkable damping capabilities, with a damping capacity of 91.2% and a peak tan δ of 1.11. Furthermore, the entropy‐driven rearrangement of ion‐dipole interactions ensures the damping properties of the SICE remain stable even at elevated temperatures (18–200 °C, with tan δ > 0.3), making it the most thermally resistant damping elastomer reported to date. Moreover, the SICE proves effective in filtering out various noises during physiological signal detection and strain sensing, highlighting its vast potential in flexible electronics.
Two‐Photon Mediated Cancer Therapy: A Comprehensive Review on Two‐Photon Photodynamic Therapy and Two‐Photon‐Activated Therapeutic Delivery Systems
Authors: Soleimany Amir , Aghmiouni Delaram Kargari , Amirikhah Masomeh , Shokrgozar Mohammad Ali , Khoee Sepideh , Sarmento Bruno 
Published: July 2024

AbstractTwo‐photon excitation (2PE) represents substantial advantages in biophotonics over traditional one‐photon excitation (1PE), offering enhanced spatial resolution and deeper tissue penetration capabilities. Since its introduction in the 1990s, two‐photon excited microscopy has spurred the rapid emergence of novel 2PE‐based applications, including photodynamic therapy (PDT) and the targeted release of biologically active agents. This review first elucidates the fundamental principles of 2PE before comprehensively examining the evolution of photosensitizers (PSs) for two‐photon PDT (2P‐PDT), covering both nanomaterials and small molecules, categorized based on their respective characteristics. Additionally, it explores advancements in PS development for integrating 2P‐PDT with other therapeutic modalities (e.g., photothermal therapy, chemotherapy, immunotherapy, gene therapy, etc.). Subsequent sections provide an overview of photoactivatable compounds with two‐photon absorption properties for the controlled release of various therapeutic agents (e.g., drugs, genes, and gasotransmitters), emphasizing their potential in anticancer applications. Last, a deep discussion deciphers the prospects and challenges of 2P‐mediated therapy in cancer treatment, particularly concerning their clinical translation.
Review for Advanced NMR Characterization of Carbon‐Based and Metal Anodes in Sodium Batteries
Authors: Chen Yongqi , Dong Zhe , Lai Shen , Li Yubin , Lv Wei , He Yan‐Bing , Kang Feiyu , Liu Ming 
Published: July 2024

AbstractBattery performance is highly related to the intrinsic properties of battery materials. To develop commercial anode electrode materials for advanced sodium‐based batteries, it is crucial to understand whose fundamental issues including compositions and structure of the bulk and interface, dynamics and electrochemical reactions during cycling. The key for present and ongoing success of carbon‐based and sodium metal anode is to overcome an intrinsic challenge associated with transport and storage of ions and complicated interface activities, especially for the sodiation process with associated risk of dendrite. Advanced Nuclear Magnetic Resonance (NMR) technique has unique advantages in characterizing the local or microstructure of anode electrode materials and their interfacial evolutions down to the atomic level by a noninvasive and nondestructive manner. In this review, an overview is provided of the recent advances in understanding the fundamental issues of carbon based and sodium metal anode materials using advanced NMR approaches. Here, latest advancements of NMR are presented for applications in characterizing structures and dynamics of anode electrode material as well as their interfacial evolutions. Finally, the prospect and limitation of NMR techniques in batteries research will be highlighted, thereby paving the way for accelerating the development of next generation sodium batteries.