bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘SKILLS FOR GROWING UP’: SUPPORTING AUTONOMY IN YOUNG PEOPLE WITH KIDNEY DISEASE
Authors: Sattoe Jane N.T. , Hilberink Sander R. , Peeters Mariëlle A.C. , van Staa AnneLoes 
Published: December 2013

SUMMARYBackground and ObjectivesEnd‐stage kidney disease (ESKD) may interfere with children's developmental task of acquiring autonomy and participation. The Skills for Growing Up tool encourages normal development towards independence and autonomy during paediatric rehabilitation. This study aimed to adapt this self‐management tool for use in paediatric nephrology, and to test whether its use is feasible in daily practice.Design and ParticipantsA Delphi study was conducted among patients, their parents, professionals and experts to adjust the tool for use in nephrology. Feasibility was studied through individual and group interviews with professionals in all Dutch paediatric nephrology centres.ResultsAgreement was reached on the areas of social participation and medical management of ESKD. Compared with the original, the new instrument holds considerable more attention for autonomy in the renal healthcare area; for example, dealing with medication and transplantation. Professionals used and appreciated the tool, but the paper form was seen to limit feasibility.ConclusionsMaking the tool available online is important. The challenge for professionals is to move beyond the focus on medical management and to consider developmental tasks when coaching their patients into adulthood.Application to PracticeThe Skills for Growing Up—Nephrology (SGU‐N) tool is a promising instrument for use by professionals in paediatric nephrology. Its use can help young people achieving autonomy and may contribute to their successful transition to adulthood and adult care.
Tillage Effects on Crop Yield and Physicochemical Properties of Sodic Soils
Authors: Singh Kripal , Mishra Ashish Kumar , Singh Bajrang , Singh Rana P. , Patra Dharani Dhar 
Published: December 2013

AbstractTillage modifies soil structure and has been suggested as a practice to improve physical, hydrological and chemical properties of compacted soils. But little is known about effect of long‐term tillage on physicochemical soil properties and crop yield on sodic soils in India. Our objective was to investigate the effect of different tillage regimes on crop yield (wheat and paddy rice) and physicochemical properties of sodic soils. Two sodic sites under conventional tillage for 5 (5‐YT; 5‐year tillage) and 9 (9‐YT; 9‐year tillage) years were selected for this study. Changes in crop yield and physicochemical soil properties were compared with a control, sodic land without any till history, that is, 0‐year tillage/untilled (0‐YT). Five replicated samples at 0‐ to 10‐cm and 10‐ to 20‐cm soils depths were analysed from each site. In the top, 0‐ to 10‐cm soil depth 5‐YT and 9‐YT sites had higher particle density (Pd), porosity, water holding capacity, hydraulic conductivity, organic carbon, total nitrogen (Nt), available nitrogen (Navail), phosphorus (Pavail) and exchangeable calcium (Exch. Ca++) than 0‐YT, whereas bulk density (Bd), C : N ratio and CaCO3 were significantly lower. Bd, pH, EC and CaCO3 increased significantly with depth in all the lands, whereas Pd, porosity, water holding capacity, hydraulic conductivity, organic carbon, Nt, Navail, Pavail and Exch. Ca++ decreased. We conclude that continuous tillage and cropping can be useful for physical and chemical restoration of sodic soils. Copyright © 2014 John Wiley & Sons, Ltd.
Catchment Rehabilitation and Hydro‐geomorphic Characteristics of Mountain Streams in the Western Rift Valley Escarpment of Northern Ethiopia
Authors: Asfaha Tesfaalem G. , Frankl Amaury , Haile Mitiku , Nyssen Jan 
Published: December 2013

AbstractThe catchments in the western Rift Valley escarpment of northern Ethiopia are highly responsive in terms of hydro‐geomorphic changes. With deforestation, dense gully and scar networks had developed by the 1980s on the escarpment between the towns of Alamata and Korem, transporting huge amounts of runoff and sediment down to the fertile and densely populated Raya Valley. To reverse this problem, catchment‐scale rehabilitation activities were initiated in the mid‐1980s. In this study, we examine the major hydro‐geomorphic response of streams after catchment rehabilitation. Scar networks in 20 adjacent catchments were mapped on Google Earth imagery of 2005, and their density was explained in terms of its corresponding Normalized Difference Vegetation Index and slope gradient. Soil and water conservation measures and vegetation recovery have reduced discharge and sediment flow which in turn resulted in various hydro‐geomorphic changes. In a multiple regression analysis, scar density was negatively related with Normalized Difference Vegetation Index and positively with average gradient of very steep slopes (r2 = 0·53, p < 0·01, n = 20). The size and amount of sediment supply to streams decreased, and various channel adjustments occurred. Notably, previously braided streams have changed to single thread streams, lateral bars have been stabilized and stream channels are narrowing and incising. Copyright © 2013 John Wiley & Sons, Ltd.
Impact of dissolved inorganic carbon concentrations and pH on growth of the chemolithoautotrophic epsilonproteobacterium Sulfurimonas gotlandica GD1T
Authors: Mammitzsch Kerstin , Jost Günter , Jürgens Klaus 
Published: December 2013

AbstractEpsilonproteobacteria have been found globally distributed in marine anoxic/sulfidic areas mediating relevant transformations within the sulfur and nitrogen cycles. In the Baltic Sea redox zones, chemoautotrophic epsilonproteobacteria mainly belong to the Sulfurimonas gotlandica GD17 cluster for which recently a representative strain, S. gotlandica GD1T, could be established as a model organism. In this study, the potential effects of changes in dissolved inorganic carbon (DIC) and pH on S. gotlandica GD1T were examined. Bacterial cell abundance within a broad range of DIC concentrations and pH values were monitored and substrate utilization was determined. The results showed that the DIC saturation concentration for achieving maximal cell numbers was already reached at 800 μmol L−1, which is well below in situ DIC levels. The pH optimum was between 6.6 and 8.0. Within a pH range of 6.6–7.1 there was no significant difference in substrate utilization; however, at lower pH values maximum cell abundance decreased sharply and cell‐specific substrate consumption increased.
Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase‐mitogen‐activated protein kinase signaling pathway
Authors: Baba Takao , Sakamoto Yosuke , Kasamatsu Atsushi , Minakawa Yasuyuki , Yokota Satoshi , Higo Morihiro , Yokoe Hidetaka , Ogawara Katsunori , Shiiba Masashi , Tanzawa Hideki , Uzawa Katsuhiro 
Published: December 2013

AbstractPersephin (PSPN) is a neurotrophic factor of the glial cell line‐derived neurotrophic factor (GDNF) family that promotes survival of multiple populations of neurons. Little is known about the relevance of PSPN in human malignancy including oral squamous cell carcinoma (OSCC). This study was undertaken to evaluate PSPN mRNA and protein expression by analyzing cellular proliferation and the cell cycle in PSPN knockdown cells in vitro. PSPN mRNA and protein were significantly (P < 0.05) up‐regulated in OSCC‐derived cells compared with human normal oral keratinocytes (n = 7). Cellular proliferation decreased significantly (P < 0.05) in PSPN knockdown cells with reduced receptor tyrosine kinase (RTK) signaling, and cell‐cycle arrest at the G1 phase resulted from up‐regulation of the cyclin‐dependent kinase inhibitors (p21Cip1, p27Kip1, p15INK4B, and p16INK4A). Furthermore, the PSPN protein expression in 101 primary OSCCs was significantly (P < 0.05) higher than in normal counterparts. Among the clinical variables analyzed, overexpression of PSPN also was related closely (P < 0.05) to tumoral size. Our results suggested that PSPN is a possible key regulator of OSCC progression via PSPN‐RET‐mitogen‐activated protein kinase activation and that PSPN overexpression may have diagnostic potential for OSCC. © 2013 Wiley Periodicals, Inc.
Cardiometabolic risk factors are influenced by Stearoyl‐CoA Desaturase (SCD) −1 gene polymorphisms and n‐3 polyunsaturated fatty acid supplementation
Authors: Rudkowska Iwona , Julien Pierre , Couture Patrick , Lemieux Simone , Tchernof André , Barbier Olivier , Vohl Marie‐Claude 
Published: December 2013

ScopeTo determine if single nucleotide polymorphisms (SNPs) in stearoyl‐CoA desaturase (SCD)‐1 gene that encodes a key enzyme for fatty acid metabolism are associated with the response of cardiometabolic risk factors to n‐3 PUFA supplementation.Methods and resultsTwo hundred and ten subjects completed a 2‐week run‐in period followed by 6‐week supplementation with 5 g of fish oil (1.9–2.2 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid). Risk factors were measured pre and post n‐3 supplementation. Fatty acid composition of plasma phospholipids was analyzed by GC and the desaturase indices SCD16 (16:1n‐7/16:0) and SCD18 (18:1n‐9/18:0) were calculated. Genotyping of eight SNPs of the SCD1 gene was performed. N‐3 PUFA supplementation decreased plasma triglycerides, as well as SCD16 and SCD18 indices, but increased fasting plasma glucose concentrations. SNPs in SCD1‐modified cardiometabolic risk factors pre and post n‐3 PUFA supplementation: triglyceride (rs508384, p = 0.0086), IL6 (rs3071, p = 0.0485), C‐reactive protein (rs3829160, p = 0.0489), and SCD18 indices (rs2234970, p = 0.0337). A significant interaction effect between the SNP and n‐3 PUFA supplementation was also observed for fasting plasma glucose levels (rs508384, p = 0.0262).ConclusionThese results suggest that cardiometabolic risk factors are modulated by genetic variations in the SCD1 gene alone or in combination with n‐3 PUFA supplementation.
ROAMER: roadmap for mental health research in Europe
Authors: Haro Josep Maria , Ayuso‐Mateos José Luis , Bitter Istvan , Demotes‐Mainard Jacques , Leboyer Marion , Lewis Shôn W. , Linszen Donald , Maj Mario , Mcdaid David , Meyer‐Lindenberg Andreas , Robbins Trevor W. , Schumann Gunter , Thornicroft Graham , Van Der Feltz‐Cornelis Christina , Van Os Jim , Wahlbeck Kristian , Wittchen Hans‐Ulrich , Wykes Til , Arango Celso , Bickenbach Jerome , Brunn Matthias , Cammarata Pamela , Chevreul Karine , Evans‐Lacko Sara , Finocchiaro Carla , Fiorillo Andrea , Forsman Anna K , Hazo Jean‐Baptiste , Knappe Susanne , Kuepper Rebecca , Luciano Mario , Miret Marta , Obradors‐Tarragó Carla , Pagano Grazia , Papp Szilvia , Walker‐Tilley Tom 
Published: December 2013

AbstractDespite the high impact of mental disorders in society, European mental health research is at a critical situation with a relatively low level of funding, and few advances been achieved during the last decade. The development of coordinated research policies and integrated research networks in mental health is lagging behind other disciplines in Europe, resulting in lower degree of cooperation and scientific impact.To reduce more efficiently the burden of mental disorders in Europe, a concerted new research agenda is necessary. The ROAMER (Roadmap for Mental Health Research in Europe) project, funded under the European Commission's Seventh Framework Programme, aims to develop a comprehensive and integrated mental health research agenda within the perspective of the European Union (EU) Horizon 2020 programme, with a translational goal, covering basic, clinical and public health research.ROAMER covers six major domains: infrastructures and capacity building, biomedicine, psychological research and treatments, social and economic issues, public health and well‐being. Within each of them, state‐of‐the‐art and strength, weakness and gap analyses were conducted before building consensus on future research priorities. The process is inclusive and participatory, incorporating a wide diversity of European expert researchers as well as the views of service users, carers, professionals and policy and funding institutions. Copyright © 2013 John Wiley & Sons, Ltd.
Advancing psychotherapy and evidence‐based psychological interventions
Authors: Emmelkamp Paul M.G. , David Daniel , Beckers Tom , Muris Peter , Cuijpers Pim , Lutz Wolfgang , Andersson Gerhard , Araya Ricardo , Banos Rivera Rosa M. , Barkham Michael , Berking Matthias , Berger Thomas , Botella Christina , Carlbring Per , Colom Francesc , Essau Cecilia , Hermans Dirk , Hofmann Stefan G. , Knappe Susanne , Ollendick Thomas H. , Raes Filip , Rief Winfried , Riper Heleen , Van Der Oord Saskia , Vervliet Bram 
Published: December 2013

AbstractPsychological models of mental disorders guide research into psychological and environmental factors that elicit and maintain mental disorders as well as interventions to reduce them. This paper addresses four areas. (1) Psychological models of mental disorders have become increasingly transdiagnostic, focusing on core cognitive endophenotypes of psychopathology from an integrative cognitive psychology perspective rather than offering explanations for unitary mental disorders. It is argued that psychological interventions for mental disorders will increasingly target specific cognitive dysfunctions rather than symptom‐based mental disorders as a result. (2) Psychotherapy research still lacks a comprehensive conceptual framework that brings together the wide variety of findings, models and perspectives. Analysing the state‐of‐the‐art in psychotherapy treatment research, “component analyses” aiming at an optimal identification of core ingredients and the mechanisms of change is highlighted as the core need towards improved efficacy and effectiveness of psychotherapy, and improved translation to routine care. (3) In order to provide more effective psychological interventions to children and adolescents, there is a need to develop new and/or improved psychotherapeutic interventions on the basis of developmental psychopathology research taking into account knowledge of mediators and moderators. Developmental neuroscience research might be instrumental to uncover associated aberrant brain processes in children and adolescents with mental health problems and to better examine mechanisms of their correction by means of psychotherapy and psychological interventions. (4) Psychotherapy research needs to broaden in terms of adoption of large‐scale public health strategies and treatments that can be applied to more patients in a simpler and cost‐effective way. Increased research on efficacy and moderators of Internet‐based treatments and e‐mental health tools (e.g. to support “real time” clinical decision‐making to prevent treatment failure or relapse) might be one promising way forward. Copyright © 2013 John Wiley & Sons, Ltd.
Conflict in Pre‐Hispanic Northwest Argentina: Implications Arising From Human Bone Trauma Patterns
Authors: Gheggi M. S. 
Published: December 2013

AbstractThe time span ranging from ca. 900 to 1450 A.D. in the South‐Central Andes has been traditionally posited as a period of social unrest, political disintegration and large‐scale conflict due to, primarily, environmental causes. However, the osteological record of traumatic injuries in a sample of 223 adult and subadult crania from different areas of Northwest Argentina does not clearly correspond to the expected scenario of pervasive and formalized armed attacks. Cranial trauma prevalence in the sample is low (17.48%), and no statistically significant differences were met between the sexes. No differences were found when comparing trauma prevalence between settlements or regions, suggesting that location or function of the sites may not have influenced in trauma frequencies. This information more comfortably agrees with a scenario of conflict where several sources of violence may have caused the record of traumatic injuries (i.e. raids, ambushes, etc). These results serve to problematize how conflict is expected to be expressed in the archaeological record, especially in osseous human remains, what sources of violence may have generated the traumatic patterns observed and the intensity of conflict in this region in particular and in the pre‐Hispanic Andes in general. Copyright © 2014 John Wiley & Sons, Ltd.
Spatiotemporal Gait Parameters for Patients with Parkinson's Disease Compared with Normal Individuals
Authors: Bovonsunthonchai Sunee , Vachalathiti Roongtiwa , Pisarnpong Apichart , Khobhun Fuengfa , Hiengkaew Vimonwan 
Published: December 2013

AbstractBackgroundGait initiation is a major motor problem for patients with Parkinson's disease (PD). To understand the gait initiation in patients with PD, fluctuation on the first three steps of initiation was examinedMethodsForce distribution measurement platform was used to record gait initiation in 10 patients with PD and healthy participants. Step length, step time and step width, as well as its coefficient of variation (CV) were investigatedResultsThe findings demonstrated significant main effect of group on step length (p < 0.001), step time (p = 0.034) and step width (p = 0.002), significant main effect of step on step time (p < 0.001) and step width (p < 0.001). No interaction between group and step (p > 0.05) was found on the variables. Compared with healthy participants, patients with PD showed significantly shorter step length in the first (p < 0.001), second (p = 0.001) and third (p = 0.001) steps and longer step time in the second step (p < 0.001). No difference in CV (p > 0.05) of the variables between groups comparison. Both groups had significant longer step time in the first step compared with the second step (PD, p < 0.001; healthy participants, p < 0.001) and the third steps (PD, p < 0.001; healthy participants, p < 0.001). They demonstrated significant wider step width in the first step when compared with the second step (PD, p = 0.043; healthy participants, p < 0.001) and the third steps (PD, p = 0.002; healthy participants, p < 0.001).ConclusionPatients with PD showed shorter step length of all steps, longer step time in the second step and similar step width when compared with healthy participants. Among the three steps, both groups demonstrated longer step time and wider step width in the first step when compared with other two step. Copyright © 2013 John Wiley & Sons, Ltd.
C‐terminal β‐strand swapping in a consensus‐derived fibronectin Type III scaffold
Authors: Teplyakov Alexey , Obmolova Galina , Malia Thomas J. , Luo Jinquan , Jacobs Steven A. , Chan Winnie , Domingo Derrick , Baker Audrey , O'Neil Karyn T. , Gilliland Gary L. 
Published: December 2013

ABSTRACTThe crystal structures of six different fibronectin Type III consensus‐derived Tencon domains, whose solution properties exhibit no, to various degrees of, aggregation according to SEC, have been determined. The structures of the five variants showing aggregation reveal 3D domain swapped dimers. In all five cases, the swapping involves the C‐terminal β‐strand resulting in the formation of Tencon dimers in which the target‐binding surface is blocked. All of the variants differ in sequence in the FG loop, which is the hinge loop in the β‐strand‐swapped dimers. The six tencon variants have between 0 and 5 residues inserted between positions 77 and 78 in the FG loop. Analysis of the structures suggests that a non‐glycine residue at position 77 and insertions of <4 residues may destabilize the β‐turn in the FG loop promoting β‐strand swapping. Swapped dimers with an odd number of inserted residues may be less stable, particularly if they contain proline residues, because they cannot form perfect β‐bridges in the FG regions that link the swapped dimers. The Tencon β‐swapped variants with the longest FG sequences are observed to form higher order hexameric or helical oligomeric structures in the crystal correlating well with the aggregation properties of these domains observed in solution. Understanding the structural basis for domain‐swapped dimerization and oligomerization will support engineering efforts of the Tencon domain to produce variants with desired biophysical properties. Proteins 2014; 82:1359–1369. © 2013 Wiley Periodicals, Inc.
Increasing Diversity Within Increasing Diversity: the Changing Ethnic Composition of London's Neighbourhoods, 2001–2011
Authors: Johnston Ron , Poulsen Michael , Forrest James 
Published: December 2013

AbstractLondon has become an ethnically much more diverse city over recent decades but has that growing macro‐scale diversity been replicated in its myriad neighbourhoods? Using recently released 2011 census data and an established methodology for classifying small areas according to the ethnic composition of their populations, this paper explores the extent and nature of change in those areas over the decade 2001–2011. It identifies two main patterns: firstly, in many parts of London where Whites previously predominated neighbourhoods are more mixed ethnically; secondly, in those areas where Whites were in a minority by 2011 there were even fewer Whites but without the development of separate enclaves where one Non‐White group predominates. The result is an ethnic landscape characterised by two types of changing diversity. Copyright © 2013 John Wiley & Sons, Ltd.
Wavy channel thin film transistor architecture for area efficient, high performance and low power displays
Authors: Hanna Amir N. , Torres Sevilla Galo A. , Ghoneim Mohamed T. , Hussain Aftab M. , Bahabry Rabab R. , Syed Ahad , Hussain Muhammad M. 
Published: December 2013

AbstractWe demonstrate a new thin film transistor (TFT) architecture that allows expansion of the device width using continuous fin features – termed as wavy channel (WC) architecture. This architecture allows expansion of transistor width in a direction perpendicular to the substrate, thus not consuming extra chip area, achieving area efficiency. The devices have shown for a 13% increase in the device width resulting in a maximum 2.5× increase in ‘ON’ current value of the WCTFT, when compared to planar devices consuming the same chip area, while using atomic layer deposition based zinc oxide (ZnO) as the channel material. The WCTFT devices also maintain similar ‘OFF’ current value, ∼100 pA, when compared to planar devices, thus not compromising on power consumption for performance which usually happens with larger width devices. This work offers an interesting opportunity to use WCTFTs as backplane circuitry for large‐area high‐resolution display applications. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Accuracy of screw placement and radiation dose in navigated dorsal instrumentation of the cervical spine: a prospective cohort study
Authors: Kraus Michael , von dem Berge Stephanie , Perl Mario , Krischak Gert , Weckbach Sebastian 
Published: December 2013

AbstractBackgroundDorsal cervical spinal fusion is a challenging procedure in fracture fixation. There is limited information in the literature about computer navigation using lateral mass screws in cases of spinal trauma.MethodsRetrospective analysis of a prospective database covering an 8 year period. All patients who received a dorsal spinal fusion due to a fracture of the cervical spine were included. Outcome parameters were screw accuracy, duration of surgery, the radiation emitted and intra‐/postoperative complications.ResultsSixteen patients, who received 67 screws (44 navigated vs 23 conventionally inserted screws) were included. Three‐dimensional (3D)‐based computer navigation prolonged the duration of surgery but helped to reduce the radiation emitted and led to significantly increased accuracy of screw positioning.ConclusionComputer navigation can increase the accuracy of lateral mass screws in spinal trauma. It prolongs the surgical procedure but reduces the emission of radiation significantly. Copyright © 2013 John Wiley & Sons, Ltd.