bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative expression of candidate genes affecting eggshell color
Authors: Zheng Chuanwei , Li Zesheng , Yang Ning , Ning Zhonghua 
Published: March 2014

AbstractThere are three pigments that affect the color of an eggshell: protoporphyrin, biliverdin and biliverdin‐zinc chelate. Protoporphyrin is the main pigment in brown and light‐brown eggshells, whereas very little protoporphyrin is found in white eggshells. Eggshell protoporphyrin is derived from the heme formation in birds. Coproporphyrinogen III oxidase (CPOX) and ferrochelatase (FECH) represent rate‐limiting enzymes for the heme‐biosynthetic pathway. Breast cancer resistance protein (BCRP), feline leukemia virus receptor (FLVCR), and heme‐responsive gene‐1 (HRG1) serve as primary transporters for both protoporphyrinogen and heme. Finally, four organic anion transporting polypeptide family members (including solute carrier organic anion transporter family, SLCO1C1, SLCO1A2, SLCO1B3 and LOC418189) may affect pigment transport within eggshells. Here we measured gene expression levels in key tissues of egg‐producing hens. We analyzed three different types of hens that generated distinct eggshell colors: white, pink or brown. Our data revealed three ways in which eggshell color was genetically influenced. First, high‐level expression of CPOX generated more protoporphyrinogen and a brown eggshell color. In contrast, high expression of FECH likely converted more protoporphyrinogen into heme, reduced protoporphyrinogen levels within the eggshell and generated a light color. Second, heme transporters also affected eggshell color. High‐level expression of BCRP, HRG1 and FLVCR were associated with brown, white and generally lighter eggshell colors, respectively. Finally, protoporphyrin precipitation also affected eggshell color, as high expression of both SLCO1A2 and SLCO1C1 were associated with brown eggshell color. As such, we have identified seven genes in which expression levels in different tissues were associated with eggshell color.
Incidence of dislocated and subluxed iris‐fixated phakic intraocular lens and outcomes following re‐enclavation
Authors: Moran Sarah , Kirwan Caitriona , O'Keefe Michael , Leccisotti Antonio , Moore Tara 
Published: March 2014

AbstractBackgroundThe purpose of this study was to establish the incidence of re‐enclavation of iris‐fixated phakic intraocular lenses in our centre and evaluate outcomes following re‐enclavation.DesignRetrospective observational case series. Single surgeon, hospital setting.ParticipantsSix hundred and nine patients (1218 eyes) implanted with iris‐fixated phakic intraocular lenses between 2000 and 2011.MethodsEyes requiring re‐enclavation were identified, and outcome measures were evaluated 12 months following re‐enclavation.Main Outcome MeasuresRate of re‐enclavation, uncorrected distance visual acuity and manifest refractive spherical equivalent were measured 12 months following re‐enclavation.ResultsTwenty‐five eyes (2% of eyes overall) of 20 patients required re‐enclavation of a dislocated or subluxed phakic intraocular lens. Eight cases (32%) dislocated secondary to trauma and 17 (68%) subluxed spontaneously. No significant difference was detected (P = 0.59) in uncorrected distance visual acuity (logMAR equivalent) 12 months post‐re‐enclavation (0.18 ± 0.04) compared with that recorded 6 months post‐initial uneventful phakic intraocular lens implantation (0.10 ± 0.06). No significant difference was detected (P = 0.95) in mean manifest refractive spherical equivalent 12 months post‐re‐enclavation (–0.59D ± 0.29D) compared with that recorded 6 months post‐initial phakic intraocular lens implantation (–0.57D ± 0.17D). Following re‐enclavation, mean endothelial cell count was 2627 ± 101 cells/mm2 12 months postoperatively in 16 eyes. This did not differ significantly from that recorded 6 months post‐initial phakic intraocular lens implantation in these eyes (P = 1).ConclusionDislocation and subluxation of iris‐fixated phakic intraocular lenses may occur secondary to trauma or spontaneously because of inadequate iris enclavation. Re‐enclavation can be carried out successfully with no significant adverse effect on clinical outcomes.
Consultant‐led, multidisciplinary balance clinic: process evaluation of a specialist model of care in a district general hospital
Authors: Trinidade A. , Yung M.W. 
Published: March 2014

ObjectiveA specialist balance clinic to effectively deal with dizzy patients is recommended by ENT‐UK. We audit the patient pathway before and following the introduction of a consultant‐led dedicated balance clinic.DesignProcess evaluation and audit.SettingENT outpatients department of a district general hospital.Main Outcome MeasuresThe journey of dizzy patients seen in the general ENT clinic was mapped from case notes and recorded retrospectively. A consultant‐led, multidisciplinary balance clinic involving an otologist, a senior audiologist and a neurophysiotherapist was then set up, and the journey was prospectively recorded and compared with that before the change.ResultsOf the 44 dizzy patients seen in the general clinic, 41% had further follow‐up consultations; 64% were given definitive or provisional diagnoses; 75% were discharged without a management plan. Oculomotor examination was not systematically performed. The mean interval between Visits 1 and 2 was 8.4 weeks and the mean number of visits was 3. In the consultant‐led dedicated balance clinic, following Visit 1, only 8% of patients required follow‐up; 97% received definitive diagnoses, which guided management; all patients left with definitive management plans in place. In all patients, oculomotor assessment was systematically performed and all patients received consultant and, where necessary, allied healthcare professional input.ConclusionsBy standardising the management experience for dizzy patients, appropriate and timely treatment can be achieved, allowing for a more seamless and efficient patient journey from referral to treatment. A multidisciplinary balance clinic led by a consultant otologist is the ideal way to achieve this.
Clinical efficacy of peramivir in adult patients with seasonal influenza during the winter of 2012 in Japan
Authors: Yoshino Yusuke , Seo Kazunori , Koga Ichiro , Kitazawa Takatoshi , Ota Yasuo 
Published: March 2014

AbstractBackgroundPeramivir is an intravenously administered neuraminidase inhibitor for influenza. The clinical efficacy of peramivir remains unclear because it is used in a limited number of countries. We compared the clinical efficacy of peramivir with that of oseltamivir in influenza patients during the 2012–2013 season.MethodsThirty‐two influenza patients who were hospitalized at Teikyo University Hospital, a teaching hospital in Tokyo, Japan, from October 2012 to March 2013 were enrolled. Among them, 23 and 9 were treated with peramivir and oseltamivir, respectively. The end points of this study were the time to defervescence and survival rate.ResultsThere were no significant differences in the clinical backgrounds of the two groups. However, patients treated with peramivir tended to have a higher incidence of consciousness disturbance [34.8% (8/23) vs 0.00% (0/9), P = 0.064]. There were no significant differences between the peramivir and oseltamivir groups with respect to the time to defervescence (30.9 ± 18.7 h vs 34.7 ± 18.6 h) or survival rate [95.7% (22/23) vs 100% (9/9), respectively].ConclusionsThe clinical efficacy of peramivir is non‐inferior to that of oseltamivir, although peramivir tended to be used in patients with serious complications. Intravenous administration of peramivir may be useful for patients with serious complications, such as consciousness disturbances.
Pulmonary embolism is associated with current morphine treatment in patients with deep vein thrombosis
Authors: Lee Cynthia Wei‐Sheng , Muo Chih‐Hsin , Liang Ji‐An , Sung Fung‐Chang , Kao Chia‐Hung , Yeh Jun‐Jun 
Published: March 2014

AbstractObjectivesThis study investigates the relationship between current morphine use and the risk of pulmonary embolism (PE) development in deep vein thrombosis (DVT) patients.MethodsWe conducted a population‐based nested case‐control retrospective analysis using the Longitudinal Health Insurance Database 2000 of Taiwan. A DVT cohort of 3668 patients with no history of PE from 1998 to 2010 and the other cohort of 174 patients who subsequently developed PE were evaluated. Morphine use was designated as ‘current’ if the prescription duration covered the index date or ended within 30 days before the index date. Logistic regression was used to estimate the odds ratios and 95% confidence intervals (CI), and the multivariable model was applied to control for age.ResultsCompared with non‐morphine users, DVT patients who received morphine within 30 days of the index date had a 4.54‐fold (95% CI = 2.30–8.97) chance of developing PE. The risk of PE development increased with an increase in cumulative dosage and in the average dosage of morphine.ConclusionThe incidence of PE in DVT patients in Taiwan is associated with current morphine treatment (≤30 days) and is dependent on dosage.
R‐split‐CHOP chemotherapy for elderly patients with diffuse large B‐cell lymphoma
Authors: Kreher Stephan , Lammer Felicitas , Augustin Dieter , Pezzutto Antonio , Baldus Claudia D. 
Published: March 2014

AbstractObjectivesChemoimmunotherapy with cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab (R‐CHOP) is the standard of care for patients with diffuse large B‐cell lymphoma (DLBCL). However, management of elderly patients is challenging as critical comorbidities often account for increased number of treatment‐related complications.Patients and methodsIn the past 8 yrs, we have treated elderly patients with a full‐dose R‐CHOP regimen by splitting the administration of cyclophosphamide and doxorubicin over 2 days (R‐split‐CHOP) to reduce peak plasma level. Here, we retrospectively analyzed the results of 30 patients with newly diagnosed DLBCL.ResultsThe overall response rate was found to be 87%, the overall survival probability after 3 yrs was 60.6% (95% CI, 42.1%–79.0%), and the progression‐free survival probability was 49.7% (95% CI, 30.4%–68.9%). Grade 3/4 infectious complications were reported in 30% of patients, yet no treatment‐related deaths occurred.ConclusionWe suggest that R‐split‐CHOP could be a valuable option to safely administer full‐dose‐intensity R‐CHOP to elderly patients at risk of treatment‐related complications.
Posture and movement characteristics of forward and backward walking in horses with shivering and acquired bilateral stringhalt
Authors: Draper A. C. E. , Trumble T. N. , Firshman A. M. , Baird J. D. , Reed S. , Mayhew I. G. , MacKay R. , Valberg S. J. 
Published: March 2014

SummaryReasons for performing studyTo investigate and further characterise posture and movement characteristics during forward and backward walking in horses with shivering and acquired, bilateral stringhalt.ObjectivesTo characterise the movement of horses with shivering (also known as shivers) in comparison with control horses and horses with acquired bilateral stringhalt.Study designQualitative video analysis of gait in horses.MethodsOwners' and authors' videos of horses with shivering or stringhalt and control horses walking forwards and backwards and manually lifting their limbs were examined subjectively to characterise hyperflexion, hyperextension and postural abnormalities of the hindlimbs. The pattern and timing of vertical displacement of a hindlimb over one stride unit was evaluated among control, shivering and stringhalt cases.ResultsGait patterns of shivering cases were characterised as follows: shivering‐hyperextension (‐HE, n = 13), in which horses subjectively showed hyperextension when backing and lifting the limb; shivering‐hyperflexion (‐HF, n = 27), in which horses showed hindlimb hyperflexion and abduction during backward walking; and shivering‐forward hyperflexion (‐FHF, n = 4), which resembled shivering‐HFbut included intermittent hyperflexion and abduction with forward walking. Horses with shivering‐HF, shivering‐FHFand stringhalt (n = 7) had a prolonged swing phase duration compared with control horses and horses with shivering‐HEduring backward walking. With the swing phase of forward walking, horses with stringhalt had a rapid ascent to adducted hyperflexion of the hindlimb, compared with a rapid descent of the hindlimb after abducted hyperflexion in horses with shivering‐FHF.ConclusionsShivering affects backward walking, with eitherHEorHFof hindlimbs, and can gradually progress to involve intermittent abducted hyperflexion during forward walking. Shivering‐HFand shivering‐FHFcan look remarkably similar to acquired bilateral stringhalt during backward walking; however, stringhalt can be distinguished from shivering‐HFby hyperflexion during forward walking and from shivering‐FHFby an acute onset of a more consistent, rapidly ascending, hyperflexed, adducted hindlimb gait at a walk.
Non catheter‐related bacteremia caused by Pseudomonas oryzihabitans in a patient undergoing hemodialysis
Authors: Hellou Elias , Artul Suheil , Omari Sohaib , Taha Mohamad , Armaly Zaher , Nseir William 
Published: March 2014

AbstractPseudomonas oryzihabitans (P. orizyhabitans) has already been reported both as a human and a zoonotic pathogen. A few cases of P. orizyhabitans bacteremia have been reported among patients who underwent peritoneal dialysis. P. orizyhabitans bacteremia has never been reported among patients on hemodialysis. We report the first case of P. orizyhabitans bacteremia in a chronic hemodialysis patient; this patient did not have a central venous catheter angioaccess as a potential portal of entry.
A systematic review investigating the effectiveness of Complementary and Alternative Medicine (CAM) for the management of low back and/or pelvic pain (LBPP) in pregnancy
Authors: Close Ciara , Sinclair Marlene , Liddle S. Dianne , Madden Elaine , McCullough Julie E.M. , Hughes Ciara 
Published: March 2014

AbstractAimTo evaluate and summarize the current evidence on the effectiveness of complementary and alternative medicine for the management of low back pain and/or pelvic pain in pregnancy.BackgroundInternational research demonstrates that 25–30% of women use complementary and alternative medicine to manage low back and pelvic pain in pregnancy without robust evidence demonstrating its effectiveness.DesignA systematic review of randomized controlled trials to determine the effectiveness of complementary and alternative medicine for low back and/or pelvic pain in pregnancy.Data sourcesCochrane library (1898–2013), PubMed (1996–2013), MEDLINE (1946–2013), AMED (1985–2013), Embase (1974–2013), Cinahl (1937–2013), Index to Thesis (1716–2013) and Ethos (1914–2013).Review methodsSelected studies were written in English, randomized controlled trials, a group 1 or 2 therapy and reported pain reduction as an outcome measure. Study quality was reviewed using Risk of Bias and evidence strength the Cochrane Grading of Recommendations and Development Evaluation Tool.ResultsEight studies were selected for full review. Two acupuncture studies with low risk of bias showed both clinically important changes and statistically significant results. There was evidence of effectiveness for osteopathy and chiropractic. However, osteopathy and chiropractic studies scored high for risk of bias. Strength of the evidence across studies was very low.ConclusionThere is limited evidence supporting the use of general CAM for managing pregnancy‐related low back and/or pelvic pain. However, the restricted availability of high‐quality studies, combined with the very low evidence strength, makes it impossible to make evidence‐based recommendations for practice.
Politicizing Europe in the National Electoral Arena: A Comparative Analysis of Five West European Countries, 1970–2010
Authors: Hutter Swen , Grande Edgar 
Published: March 2014

AbstractAlthough politicization has become a key concept in European integration studies, it is still contested whether, when and to what extent European issues have become politicized in domestic political arenas. This article contributes to this discussion both in conceptual and empirical terms. It uses a new multidimensional index of politicization to systematically trace the development of politicization in national election campaigns in five West European countries (Austria, Britain, France, Germany and Switzerland) from the 1970s to 2010. The findings provide clear evidence that Europe has indeed been politicized in the past decades. Moreover, two different paths towards such a politicization are identified. One of these paths is dominated by populist radical parties from the right, while the other path is shaped by the conflict between mainstream parties in government and opposition. On both paths, conflicts over membership play an important role and cultural‐identitarian framing strategies are used.
Student Midwives’ Duty Hours: Risks, Standards, and Recommendations
Authors: Lawrence Rachel , Kantrowitz‐Gordon Ira , Landis Andrea 
Published: March 2014

IntroductionA growing body of literature has emerged describing the risks of extended‐duty shifts and sleep deprivation. Worldwide, midwifery organizations have not adopted standards for practitioner or student duty shifts. This project reviews the literature related to extended‐duty shifts in an effort to develop evidence‐based recommendations for student nurse‐midwives/student midwives (SNMs/SMs).MethodsA comprehensive literature search was conducted through electronic databases, major journals, and reference lists published in English since January 2001. Primary research studies evaluating sleep deprivation and shift duration were included. Studies that did not include the target population (shift workers) and those that formed conclusions related to extended‐duty shifts greater than 30 hours were excluded. In addition, an extensive worldwide review of duty‐hour recommendations from more than 300 health care organizations was conducted.ResultsA total of 40 studies met the inclusion criteria. Extended‐duty shifts (those greater than 12 hours) increased the risk for cognitive and physical functional errors, safety concerns, and decreased quality of life from sleep deprivation. Cognitive function errors included attention lapses, visual tracking errors, decreased mentation and immediate recall, and decreased learning capacity. Physical errors included decreased motor skills and slowed reaction times in clinical simulations. These deficits led to an increased risk of motor vehicle accidents, needle sticks, and performance equivalent to unsafe blood alcohol concentrations. An overall decrease in quality of life and job satisfaction was linked to extended‐duty shifts. Seven organizations for medical residents or advanced practice nurses have developed policy statements on duty shifts, with extended‐duty shift limitations between 12 and 24 hours.DiscussionThe risks associated with extended‐duty shifts may inhibit the development of SNMs/SMs into competent practitioners and place patients at risk. It is recommended that midwifery education programs adopt evidence‐based limitations for the duty shifts of SNMs/SMs.
Proposed nurse‐led initiatives in improving physical health of people with serious mental illness: a survey of nurses in mental health
Authors: Happell Brenda , Platania‐Phung Chris , Scott David 
Published: March 2014

Aims and objectivesTo identify nurse perceptions on the potential value of general and specific nursing approaches to improving physical health outcomes of people with serious mental illness.BackgroundPeople diagnosed with serious mental illnesses experience heightened rates of physical illnesses and can be supported better via healthcare system prevention and management. Nurses working in mental health are a critical part of a system‐wide approach to improving physical health care, but there is little known on their views on specific approaches within Australia (e.g. screening for risks, stigma reduction).DesignA national, cross‐sectional and nonrandom survey study delivered online.MethodsMembers of the Australian College of Mental Health Nurses (n = 643), representing nurses employed in mental healthcare services across Australia (71·6% from public mental health services). Participants were asked to rate the potential of nine nurse‐based strategies for improving physical health (options: ‘yes’, ‘no’, ‘not sure’) and the potential value of 10 nursing and general strategies for improving physical health (rating from ‘negative value’ to ‘significant value’).ResultsThere was a high endorsement of all nine nurse‐based strategies for physical health (e.g. lifestyle programmes, screening, linking services), although there was less support for reducing antipsychotics or advocating for fewer side effects. Participants mainly viewed all strategies as of moderate to significant value, with the most promising value attached to colocation of primary and mental care services, lifestyle programmes and improving primary care services (reduce stigma, train GPs).ConclusionsAustralian nurses working in mental health services view a range of nurse‐based strategies for improving physical healthcare services and standards as important.Relevance to clinical practiceNurses collectively need to work with consumers, health agencies and the general public to further define how to organise and implement physical health integration strategies, towards more comprehensive health care of people with serious mental illness.
Assessment of atrial electromechanical delay in patients with polycystic ovary syndrome in both lean and obese subjects
Authors: Taşolar Hakan , Mete Türkan , Ballı Mehmet , Altun Burak , Çetin Mustafa , Yüce Tuncay , Taşolar Sevgi , Otlu Ömür , Bayramoğlu Adil , Pekdemir Hasan 
Published: March 2014

AbstractAimEven though polycystic ovary syndrome (PCOS) is characterized by increased inflammatory activity and insulin resistance, there is no clinical data about whether risk of atrial fibrillation are increased in these patients. We aimed to evaluate atrial conduction parameters predicting atrial involvement in this patient group.MethodsThe study population comprised 50 women 18–40 years of age who had been diagnosed with PCOS. The patients were divided into two groups: lean women (L‐PCOS) with a body mass index (BMI) under 25 kg/m2 and obese women (O‐PCOS) with a BMI greater than 30 kg/m2. Twenty‐five age‐matched lean healthy women were enrolled voluntarily as the control group. Difference between maximum and minimum P‐wave duration was calculated and was defined as P‐wave dispersion (Pd). Inter‐ and intra‐atrial electromechanical delays (inter‐AED, intra‐AED, respectively) were measured with tissue Doppler imaging.ResultsInter‐ and intra‐AED parameters were higher in the L‐PCOS group when compared with control subjects (anova, P = 0.004 and P = 0.013, respectively), and were also significantly higher in the O‐PCOS group compared with other groups (anova, P < 0.001 for both). The regression analyses indicated that Homeostasis Model of Assessment – Insulin Resistance (HOMA‐IR) (β = 0.603, P < 0.001) and BMI (β = 0.379, P < 0.001) were the independent predictors of inter‐AED, HOMA‐IR (β = 0.835, P < 0.001) was an independent predictor of intra‐AED, and BMI (β = 0.457, P = 0.006) and the left atrial diameter (β = 0.350, P < 0.034) were independent predictors of Pd.ConclusionConsequently, our findings provide data regarding prolonged atrial conduction parameters in PCOS patients, especially when accompanied by obesity.