bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposed therapeutic strategy for adult low-grade glioma based on aggressive tumor resection
Authors: Nitta Masayuki , Muragaki Yoshihiro , Maruyama Takashi , Ikuta Soko , Komori Takashi , Maebayashi Katsuya , Iseki Hiroshi , Tamura Manabu , Saito Taiichi , Okamoto Saori , Chernov Mikhail , Hayashi Motohiro , Okada Yoshikazu 
Published: January 2015

OBJECT
There is no standard therapeutic strategy for low-grade glioma (LGG). The authors hypothesized that adjuvant therapy might not be necessary for LGG cases in which total radiological resection was achieved. Accordingly, they established a treatment strategy based on the extent of resection (EOR) and the MIB-1 index: patients with a high EOR and low MIB-1 index were observed without postoperative treatment, whereas those with a low EOR and/or high MIB-1 index received radiotherapy (RT) and/or chemotherapy. In the present retrospective study, the authors reviewed clinical data on patients with primarily diagnosed LGGs who had been treated according to the above-mentioned strategy, and they validated the treatment policy. Given their results, they will establish a new treatment strategy for LGGs stratified by EOR, histological subtype, and molecular status.

METHODS
One hundred fifty-three patients with diagnosed LGG who had undergone resection or biopsy at Tokyo Women's Medical University between January 2000 and August 2010 were analyzed. The patients consisted of 84 men and 69 women, all with ages ≥ 15 years. A total of 146 patients underwent surgical removal of the tumor, and 7 patients underwent biopsy.

RESULTS
Postoperative RT and nitrosourea-based chemotherapy were administered in 48 and 35 patients, respectively. Extent of resection was significantly associated with both overall survival (OS; p = 0.0096) and progression-free survival (PFS; p = 0.0007) in patients with diffuse astrocytoma but not in those with oligodendroglial subtypes. Chemotherapy significantly prolonged PFS, especially in patients with oligodendroglial subtypes (p = 0.0009). Patients with a mutant IDH1 gene had significantly longer OS (p = 0.034). Multivariate analysis did not identify MIB-1 index or RT as prognostic factors, but it did identify chemotherapy as a prognostic factor for PFS and EOR as a prognostic factor for OS and PFS.

CONCLUSIONS
The findings demonstrated that EOR was significantly correlated with patient survival; thus, one should aim for maximum tumor resection. In addition, patients with a higher EOR can be safely observed without adjuvant therapy. For patients with partial resection, postoperative chemotherapy should be administered for those with oligodendroglial subtypes, and repeat resection should be considered for those with astrocytic tumors. More aggressive treatment with RT and chemotherapy may be required for patients with a poor prognosis, such as those with diffuse astrocytoma, 1p/19q nondeleted tumors, or IDH1 wild-type oligodendroglial tumors with partial resection.
Multisession stereotactic radiosurgery for large vestibular schwannomas
Authors: Casentini Leopoldo , Fornezza Umberto , Perini Zeno , Perissinotto Egle , Colombo Federico 
Published: January 2015

OBJECT
Microsurgery is not the only option for larger vestibular schwannomas (VSs); recent reviews have confirmed the feasibility and efficacy of radiosurgery for larger VSs. This study illustrates the outcomes of a series of large VSs after multisession stereotactic radiosurgery (SRS).

METHODS
A series of 33 VSs larger than 8 cm3 (range 8–24 cm3, mean 11 cm3, median 9.4 cm3) were treated using the CyberKnife from 2003 to 2011 with the multisession SRS technique in 2–5 fractions (14–19.5 Gy). Five patients had undergone surgical removal and 5 had ventriculoperitoneal shunts. Nine patients were eligible for but refused surgery. Twelve patients were older than 70 years and 5 were younger than 40 years. Two female patients had neurofibromatosis.

RESULTS
The follow-up period ranged from 12 to 111 months (median 48 months); radiological growth control was achieved in 94% of cases: 19 tumors (58%) displayed no size variation or reduction in tumor diameter; 12 (36%), after a transient enlargement, presented with arrested growth or shrinkage. Seven patients had a volume reduction of more than 50%. Two patients (6%) needed debulking and 2 were treated with ventriculoperitoneal shunts. Actuarial progressionfree survival rates at 1 year and 5 years were 97% and 83%, respectively. Hearing was retained in 7 of the 8 patients with serviceable baseline hearing. Adverse events were limited to 1 case each of vertigo, tongue paresthesia, and trigeminal neuralgia.

CONCLUSIONS
The good control rate obtained with multisession SRS deepens the controversy of the radiobiology of VSs and may extend the indication of radiation therapy (fractionated or SRS) for large VSs to include patients without symptoms of mass effect. The limited number of cases and short follow-up period do not provide sufficient support for widespread application of multisession SRS in young patients. Further studies with multisession SRS are warranted.
Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury
Authors: Zhang Yanlu , Chopp Michael , Meng Yuling , Katakowski Mark , Xin Hongqi , Mahmood Asim , Xiong Ye 
Published: January 2015

OBJECT
Transplanted multipotent mesenchymal stromal cells (MSCs) improve functional recovery in rats after traumatic brain injury (TBI). In this study the authors tested a novel hypothesis that systemic administration of cell-free exosomes generated from MSCs promotes functional recovery and neurovascular remodeling in rats after TBI.

METHODS
Two groups of 8 Wistar rats were subjected to TBI, followed 24 hours later by tail vein injection of 100 μg protein of exosomes derived from MSCs or an equal volume of vehicle (phosphate-buffered saline). A third group of 8 rats was used as sham-injured, sham-treated controls. To evaluate cognitive and sensorimotor functional recovery, the modified Morris water maze, modified Neurological Severity Score, and foot-fault tests were performed. Animals were killed at 35 days after TBI. Histopathological and immunohistochemical analyses were performed for measurements of lesion volume, neurovascular remodeling (angiogenesis and neurogenesis), and neuroinflammation.

RESULTS
Compared with the saline-treated group, exosome-treated rats with TBI showed significant improvement in spatial learning at 34–35 days as measured by the modified Morris water maze test (p < 0.05), and sensorimotor functional recovery (i.e., reduced neurological deficits and foot-fault frequency) was observed at 14–35 days postinjury (p < 0.05). Exosome treatment significantly increased the number of newly generated endothelial cells in the lesion boundary zone and dentate gyrus and significantly increased the number of newly formed immature and mature neurons in the dentate gyrus as well as reducing neuroinflammation.

CONCLUSIONS
The authors demonstrate for the first time that MSC-generated exosomes effectively improve functional recovery, at least in part, by promoting endogenous angiogenesis and neurogenesis and by reducing inflammation in rats after TBI. Thus, MSC-generated exosomes may provide a novel cell-free therapy for TBI and possibly for other neurological diseases.
A new leak-tight borehole casing at Dome Concordia station, Antarctica, for the SUBGLACIOR project
Authors: Duphil Romain , Possenti Philippe , Piard Luc 
Published: January 2015

AbstractIn the frame of the SUBGLACIOR project, a new type of casing has been installed for testing during the 2013/14 austral summer season at Dome Concordia station, Antarctica. The SUBGLACIOR probe requires a full fluid column up to the surface, in order to circulate fluid for ice-chips recovery. This makes it essential that the casing is leak-tight through the porous firn column. We have evaluated existing solutions before opting to test a new method. This new system is made of polyethylene pipes which are welded together at the surface while the casing pipes are lowered into the reamed borehole. It is simple and lightweight and allows the casing to be installed quickly with optimum chance of being leak-tight. The installed casing has been tested both with compressed air and drilling fluids and has proven to work.
Growth and Yield of Basmati Rice as Affected by Planting Date in Boro Season
Authors: Mannan MA , Bhuiya MSU , Akhand MIM , Rana MM , Zahan A 
Published: January 2015

The experiment was conducted at the Bangladesh Rice Research Institute Farm, Gazipur, in Boro season. BasmatiPNR, Basmati370, Basmati375 and Basmati-D were transplanted started from 10 December, and continued up to 25 January in the following year, at an interval of 15 days. Forty day old seedlings were transplanted spaced at 20 cm × 15 cm, to find out the optimum planting time and to select the Basmati varieties having high yield potential. The tallness of plants, number of tillers and dry matter were increased with the advancement of planting dates. On the country, number of panicles, grains panicle-1, panicle length, grain yield and growth duration decreased as delayed planting dates. The short stature BasmatiPNR and tall plant of Basmati375 exhibited higher number of panicles, grains panicle-1 and heavier individual grain which contributed to increase grain yield. Thus, high yield potential varieties BasmatiPNR and Basmati375 to be planted in optimum time on 10 December, to obtain maximum grain yield of rice in Boro season. DOI: http://dx.doi.org/10.3329/jsf.v11i2.21594 Journal of Science Foundation, 2013;11(2):37-42
Elites baleares: epigrafía y movilidad socio-geográfica durante el siglo II dC
Authors: Sanchez Leon Maria Luisa 
Published: January 2015

Balearic elites: epigraphy and social-geographic mobility during the 2nd Century A.D.
This work analyses several cases of social-geographical mobility as witnessed by the epigraphic documentation of the Balearic Islands and Tarraco during the 2nd Century A. D. In a first step, the mobility takes place in the Islands local civil elite, then progresses, for the most outstanding members of the group, into the provincial elite.
Les banquets dans les cités grecques : bilan historiographique
Authors: Schmitt-Pantel Pauline 
Published: January 2015

Banquets in the Greek cities: historiographic review.
The review takes into account the bibliography of the researches on the banquets in the Greek cities from 1991 to 2011. These new researches are first presented in a chronological order from the Mycenean time to the Hellenistic period. Then emphasis is put on some themes such as the meals in the framework of the associations, the discourses on food and on banquets, banquet and gender.
D’Apicius à la table des rois « barbares »
Authors: Cabouret Bernadette 
Published: January 2015

From Apicius to the table of the barbarian kings.
Interest in the history of diet and of feeding practices, in the field of social and cultural history, is to be found also in studies on late Antiquity, which is not a simple transition period between Antiquity and the Middle Ages. Several orientations can be drawn out of a review of works from the last twenty, if not thirty years. The traditional social approach (culinary taste as a sign of distinction) is completed by the study of political rituals, and also by a more economical point of view. Finally, in a cultural perspective, affirmation of identity through cooking practices is considered, without neglecting the contribution of anthropology, which takes a diachronic interest in human experience. Therefore, Alimentary practices and rituals are a promising field of research.
A Synoptic Account of Flora of Solapur District, Maharashtra (India)
Authors: Garad Krushnadeoray , Gore Ramchandra , Gaikwad Sayajirao 
Published: January 2015

The present paper provides the first systematic and comprehensive account of the flora of Solapur district of Maharashtra (India). The flora of this region demonstrates a wide range of species diversity and growth forms. The vegetation of the district mainly represents tropical dry deciduous forests, thorny open scrub and vast grasslands. During the present work, a total of 1441 taxa belonging to 699 genera and 125 families of flowering plants were recorded. A new species Crinum solapurense Gaikwad et al. is described. Fabaceae is the dominant family with 210 taxa, followed by Poaceae (157 taxa), Asteraceae (85 taxa), Malvaceae (68 taxa) and Euphorbiaceae (48 taxa). Acacia is the largest genus with 25 taxa, followed by Euphorbia (23), Cyperus (22), Crotalaria (19) and Ipomoea (19). The herbaceous flora of the district is notable as it amounts to 56.21% of the whole of flora. The ratio of indigenous woody to herbaceous components is 1:1.28. The proportion of indigenous taxa (978) to the cultivated ones (460) is 1.35: 0.5 in the district.
Chronic Obstructive Pulmonary Disease Is Common in Never-smoking Patients with Primary Sjögren Syndrome
Authors: Nilsson Anna Matilda , Diaz Sandra , Theander Elke , Hesselstrand Roger , Piitulainen Eeva , Ekberg Olle , Wollmer Per , Mandl Thomas 
Published: January 2015

Objective.To assess the prevalence of chronic obstructive pulmonary disease (COPD) in patients with primary Sjögren syndrome (pSS) and to study the association of COPD with cigarette smoking, radiographic features, respiratory symptoms, disease activity, and laboratory inflammatory and serological features in patients with pSS.Methods.Fifty-one consecutive patients with pSS (mean age 60 yrs, range 29–82 yrs, 49 women) were assessed by pulmonary function tests (PFT). The PFT results were compared with previously studied population-based controls, standardizing results with regard to sex, age, height, weight, and cigarette smoking. In addition, patients with pSS were assessed by computed tomography of the chest, the European League Against Rheumatism Sjögren Syndrome Disease Activity Index and Patient Reported Index, the St. George’s Respiratory Questionnaire (which evaluates respiratory symptoms), and by laboratory inflammatory and serological tests.Results.Forty-one percent of all patients with pSS and 30% of the never-smoking patients with pSS fulfilled the Global Initiative for Chronic Obstructive Lung Disease criteria for COPD. Vital capacity (VC), forced expiratory volume in 1 s (FEV1), FEV1/VC ratio, and DLCO were significantly decreased while residual volume (RV) and the RV/total lung capacity ratio were significantly increased in patients with pSS. Moderate correlations between PFT results, symptoms, and disease activity were found. However, laboratory inflammatory and serological features were poorly associated with PFT results in patients with pSS.Conclusion.COPD was a common finding in patients with pSS, even among never-smoking patients. An obstructive pattern was the predominant PFT finding in patients with pSS, although a superimposed restrictive lung disease could not be excluded. The results suggest that the disease per se is involved in the development of COPD in pSS.
Rates of Serious Infections and Malignancies Among Patients with Rheumatoid Arthritis Receiving Either Tumor Necrosis Factor Inhibitor or Rituximab Therapy
Authors: Aaltonen Kalle Jyri , Joensuu Jaana Tuulikki , Virkki Liisa , Sokka Tuulikki , Aronen Pasi , Relas Heikki , Valleala Heikki , Rantalaiho Vappu , Pirilä Laura , Puolakka Kari , Uusitalo Tea , Blom Marja , Konttinen Yrjö Tapio , Nordström Dan 
Published: January 2015

Objective.Because of the role of tumor necrosis factor (TNF) in host defense, it was hypothesized that its inhibition might lead to an increased risk of malignancies and infections. The objective of our study was to assess the incidence of serious infections leading to hospitalization and malignancies among patients with rheumatoid arthritis (RA) receiving either TNF inhibitor or rituximab (RTX) therapy.Methods.The study population was identified from the National Register for Biologic Treatment in Finland and the hospital records of Central Finland Central Hospital for conventional disease-modifying antirheumatic drug (cDMARD) users. Data on infections and malignancies were acquired from national healthcare registers. A Poisson model was used to calculate the adjusted incidence rate ratios (aIRR) and was composed of age, sex, time from diagnosis, year of the beginning of the followup, rheumatoid factor status, Disease Activity Score at 28 joints, Health Assessment Questionnaire, prior malignancy, prior serious infection, prior biologic use, and time-updated use of methotrexate, sulfasalazine, hydroxychloroquine, and oral corticosteroids as confounders.Results.In total, during the followup of 10,994 patient-years, 92 malignancies and 341 serious infections were included in the analyses. The aIRR of infections compared to cDMARD users were 1.2 (95% CI 0.63–2.3), 0.84 (95% CI 0.53–1.3), 0.98 (95% CI 0.60–1.6), and 1.1 (95% CI 0.59–1.9) for the patients treated with infliximab (IFX), etanercept, adalimumab, and RTX, respectively. The crude rates of malignancies were highest among the users of cDMARD and RTX, and lowest among patients treated with IFX with no differences in aIRR.Conclusion.Our results provide some reassurance of the safety of biologic treatments in the treatment of RA.
Safety and Efficacy of Rituximab in Childhood-onset Systemic Lupus Erythematosus and Other Rheumatic Diseases
Authors: Tambralli Ajay , Beukelman Timothy , Cron Randy Quentin , Stoll Matthew Laurence 
Published: January 2015

Objective.Rituximab (RTX) has been used to treat many pediatric autoimmune conditions. We investigated the safety and efficacy of RTX in a variety of pediatric autoimmune diseases, especially systemic lupus erythematosus (SLE).Methods.Retrospective study of children treated with RTX. Effectiveness data was recorded for patients with at least 12 months of followup; safety data was recorded for all subjects.Results.The study included 104 children; 50 had SLE. Improvements in corticosteroid dosage, physician’s global assessment of disease activity, and SLE-associated markers of disease activity were seen. The incidence of hospitalized infections was similar to previous studies of patients with childhood-onset SLE.Conclusion.RTX can be safely administered to children and appears to contribute to decreased disease activity and steroid burden.
Adaptation et réflexivité
Authors: Jacquot Sophie , Vitale Tommaso 
Published: January 2015

Cet article part d’un premier constat, relatif à un usage très différencié des mobilisations juridiques par deux acteurs collectifs transnationaux, le Lobby européen des femmes (LEF) et le Forum européen des Roms et des gens du voyage (FERV) qui pourtant appartiennent au même secteur européen de la lutte contre les discriminations. Il a pour objectif d’expliquer les raisons de cet usage différencié, et de discuter les dimensions d’analyse pertinentes. Il s’inscrit dans la problématique plus générale de la réponse des acteurs collectifs au changement de l’action publique. Les données empiriques ont été recueillies sur la base d’un principe de triangulation entre sources secondaires, sources documentaires et entretiens semi-directifs et elles ont été élaborées dans une optique qualitative de process-tracing . Dans une première partie nous explorons les différentes stratégies de promotion des droits du LEF et du FERV (le droit comme référence et le droit comme ressource), pour nous concentrer ensuite sur les principaux facteurs à l’origine de cette situation contrastée : le rôle des ressources organisationnelles des groupes et des cadres d’identité collective, mais également le rôle des effets itératifs liés aux interactions entre groupes et leur positionnement au sein du système européen de gouvernance. L’apport principal de ce travail comparatif est de montrer que face aux évolutions des modalités de gouvernance, les acteurs collectifs ont dû s’adapter de façon réflexive, pas seulement en regardant les marges de manœuvre et les incitations existantes, mais avec une forte attention à leur propre composition, à la recherche de formules organisationnelles et stratégiques capables de prendre en compte les conflits internes et à leur environnement concurrentiel.
Effets d'état
Authors: Ghamroun Samer 
Published: January 2015

Malgré un format institutionnel classique, l’État libanais ne présente pas la plupart des propriétés par lesquelles la sociologie politique caractérise le pouvoir étatique. Il figure ainsi régulièrement dans la liste des États faibles ou même en échec. Cet article remet en question la pertinence de cette qualification en comparant trois mobilisations de droits qui se sont déroulées au Liban ces dix dernières années (protection de l’enfant en danger, protection des femmes victimes de violences familiales, augmentation de l’âge de garde de l’enfant en faveur de la mère dans la communauté sunnite). Ces mobilisations ont eu lieu dans le domaine du droit de la famille où l’État n’a jamais mis en œuvre des politiques publiques centrales, laissant à chaque communauté religieuse une autonomie juridique et judiciaire importante. Ce travail conteste cette absence étatique présupposée en étudiant des transformations et des outputs inexplicables par le simple rapport de force entre acteurs des mobilisations et contre mobilisations. Ces effets d’État ne passent pas par les éléments traditionnels recherchés par la sociologie de l’action publique : des budgets, une bureaucratie, des règles centrales obligatoires. Il s’agit ici de formes originales d’étatisation par concurrence, par standardisation ou par synthèse entre aspirations juridiques opposées difficilement conciliables en dehors des institutions centrales.
L'autonomie de l'équilibriste
Authors: Baudot Pierre-Yves , Revillard Anne 
Published: January 2015

Alors que les travaux sur la « politique des droits » menés dans le prolongement de ceux de Stuart Scheingold abordent la concrétisation des droits des individus à partir d’une focale sur l’arène judiciaire et les mobilisations qui l’entourent, cet article s’intéresse à l’action plus discrète et quotidienne des institutions administratives. Il prend appui sur la comparaison de deux institutions ayant pour mission de favoriser l’accès de leurs publics aux droits qui leur sont juridiquement reconnus, le Médiateur de la République et les Maisons départementales des personnes handicapées (MDPH). Toutes deux fonctionnent comme des intermédiaires institutionnels de la concrétisation des droits, dont l’action porte plus précisément sur la définition de l’éligibilité des individus aux droits auxquels ils prétendent. En amont, leur intervention est subordonnée à la soumission d’un dossier par des usagers et, en aval, l’effectivité des droits qu’elles défendent ou notifient dépend de l’action d’autres institutions. Médiateur et MDPH se trouvent donc dans une position d’interface entre les demandes des usagers et l’environnement institutionnel auquel elles donnent accès. Dans cette configuration, elles apparaissent comme des équilibristes, constamment soumises aux forces opposées de la défense des usagers d’un côté et de la préservation de l’administration de l’autre. Leur autonomie institutionnelle s’incarne dans leur capacité, toujours fragile, à intégrer les contraintes contraires de leur environnement et afficher l’autonomie de leurs décisions.
Musées et soft power dans le Golfe persique
Authors: Kazerouni Alexandre 
Published: January 2015

Comment comprendre ce changement d’image qui a vu l’ancienne Côte des pirates devenir un des nœuds de la mondialisation des musées, des compétitions sportives et des universités occidentales ? Certes, son pétrole et son gaz l’expliquent, mais ils ne répondent pas à eux seuls à cet étonnant constat. En tentant de déconstruire le discours qui les analyse comme outils d’un soft power , cet article vise à montrer que ces dispositifs d’accession à la visibilité internationale sont d’abord des plateformes légales d’élargissement à l’Occident du cercle des bénéficiaires de la redistribution de la rente pétrolière et gazière et, à ce titre, parties intégrantes d’un hard power .