bluuebunny/crossref_metadata_2025_split huggingface dataset:
Home blood pressure monitoring, secure electronic messaging and medication intensification for improving hypertension control
Authors: Cook A.J. , Anderson M.L. , Catz S.L. , Fishman P.A. , Carlson J. , Johnson R. , Green B.B. , Ralston J.D. 
Published: March 2014

Summary
Objective: We evaluated the role of home monitoring, communication with pharmacists, medication intensification, medication adherence and lifestyle factors in contributing to the effectiveness of an intervention to improve blood pressure control in patients with uncontrolled essential hypertension.
Methods: We performed a mediation analysis of a published randomized trial based on the Chronic Care Model delivered over a secure patient website from June 2005 to December 2007. Study arms analyzed included usual care with a home blood pressure monitor and usual care with home blood pressure monitor and web-based pharmacist care. Mediator measures included secure messaging and telephone encounters; home blood pressure monitoring; medications intensification and adherence and lifestyle factors. Overall fidelity to the Chronic Care Model was assessed with the Patient Assessment of Chronic Care (PACIC) instrument. The primary outcome was percent of participants with blood pressure (BP) <140/90 mm Hg.
Results: At 12 months follow-up, patients in the web-based pharmacist care group were more likely to have BP <140/90 mm Hg (55%) compared to patients in the group with home blood pressure monitors only (37%) (p = 0.001). Home blood pressure monitoring accounted for 30.3% of the intervention effect, secure electronic messaging accounted for 96%, and medication intensification for 29.3%. Medication adherence and self-report of fruit and vegetable intake and weight change were not different between the two study groups. The PACIC score accounted for 22.0 % of the main intervention effect.
Conclusions: The effect of web-based pharmacist care on improved blood pressure control was explained in part through a combination of home blood pressure monitoring, secure messaging, and antihypertensive medication intensification.
Citation: Ralston JD, Cook AJ, Anderson ML, Catz SL, Fishman PA, Carlson J, Johnson R, Green BB. Home blood pressure monitoring, secure electronic messaging and medication intensification for improving hypertension control: a mediation analysis. Appl Clin Inf 2014; 5: 232–248 http://dx.doi.org/10.4338/ACI-2013-10-RA-0079
Association between use of a health information exchange system and hospital admissions
Authors: Kern L.M. , Campion T.R. , Silver M.D. , Kaushal R. , Vest J.R. 
Published: March 2014

Summary
Objective: Relevant patient information is frequently difficult to obtain in emergency department (ED) visits. Improved provider access to previously inaccessible patient information may improve the quality of care and reduce hospital admissions. Health information exchange (HIE) systems enable access to longitudinal, community-wide patient information at the point of care. However, the ability of HIE to avert admissions is not well demonstrated. We sought to determine if HIE system usage is correlated with a reduction in admissions via the ED.
Methods: We identified 15,645 adults from New York State with an ED visit during a 6-month period, all of whom consented to have their information accessible in the HIE system, and were continuously enrolled in two area health plans. Using claims we determined if the ED encounter resulted in an admission. We used the HIE’s system log files to determine usage during the encounter. We determined the association between HIE system use and the likelihood of admission to the hospital from the ED and potential cost savings.
Results: The HIE system was accessed during 2.4% of encounters. The odds of an admission were 30% lower when the system was accessed after controlling for confounding (odds ratio = 0.70; 95%C I= 0.52, 0.95). The annual savings in the sample was $357,000.
Conclusion: These findings suggest that the use of an HIE system may reduce hospitalizations from the ED with resultant cost savings. This is an important outcome given the substantial financial investment in interventions designed to improve provider access to patient information in the US.
Citation: Vest JR, Kern LM, Campion TR Jr, Silver MD, Kaushal R. Association between use of a health information exchange system and hospital admissions. Appl Clin Inf 2014; 5: 219–231 http://dx.doi.org/10.4338/ACI-2013-10-RA-0083
Simulation of Apical and Atrio-aortic VAD in Patients with Transposition or Congenitally Corrected Transposition of the Great Arteries
Authors: Di Molfetta Arianna , Jacobs Steven , Fresiello Libera , Verbelen Tom , Trivella Maria G. , Meyns Bart , Ferrari Gianfranco 
Published: March 2014

Purpose VADs could be used for transportation of the great arteries (TGA) and for congenitally corrected transposition (ccTGA) treatment. A cardiovascular numerical model (NM) may offer a useful clinical support in these complex physiopathologies. This work aims at developing and preliminarily verifying a NM of ccTGA and TGA interacting with VADs. Methods Hemodynamic data were collected at the baseline (BL) and three months (FUP) after apical (atrio-aortic) VAD implantation in a TGA (ccTGA) patient and used in a lumped parameter NM to simulate the patient's physiopathology. Measured (MS) and simulated (SIM) data were compared. Results MS and SIM data are in accordance at the BL and at FUP. Cardiac output (l/min): BL_m = 2.9 ± 0.4, BL_s = 3.0 ± 0.3; FUP_m = 4.2 ± 0.2, FUP_s = 4.1 ± 0.1. Right atrial pressure (mmHg): BL_m = 21.4 ± 4.1, BL_s = 18.5 ± 4.5; FUP_m = 13 ± 4, FUP_s = 14.8 ± 3.6. Pulmonary arterial pressure (mmHg): BL_m = 56 ± 6.3, BL_s = 57 ± 2, FUP_m = 37.5 ± 7.5, FUP_s = 35.5 ± 5.9. Systemic arterial pressure (mmHg): BL_m = 71 ± 2, BL_s = 74.6 ± 2.1; FUP_m = 84 ± 9, FUP_s = 81.9 ± 9.8. Conclusions NM can simulate the effect of a VAD in complex physiopathologies, with the inclusion of changes in circulatory parameters during the acute phase and at FUP. The simulation of differently assisted physiopathologies offers a useful support for clinicians.
Median Frequencies of Prolonged Ventricular Fibrillation treated by V-A ECMO Correspond to a Return of Spontaneous Circulation Rate
Authors: Havranek Stepan , Belohlavek Jan , Mlcek Mikulas , Huptych Michal , Boucek Tomas , Svoboda Tomas , Fichtl Jaromir , Hrachovina Matej , Linhart Ales , Kittnar Otomar 
Published: March 2014

Background The aim of our study was to analyze, in a pig model of prolonged ventricular fibrillation (VF) treated by veno-arterial extracorporeal membrane oxygenation (ECMO), the time dependent changes of VF wavelet frequency obtained from intracardial signals and its relations to return of spontaneous circulation (ROSC). Methods 11 female pigs (50.3 ± 3.4 kg) under general anesthesia had undergone 15 min of VF with ECMO flow of 5 to 10 ml/kg per min simulating “untreated” VF followed by continued VF with full ECMO flow of 100 ml/kg per min. The median frequency (MF) of VF from right ventricular apex, coronary perfusion pressure, myocardial oxygen metabolism and resuscitability were determined. Results Median (interquartile range) of MF of fibrillatory wavelets in minute 15 of low ECMO flow [9.7 Hz (8.3; 10.1)] was not significantly changed in comparison to minute 1 [10.5 Hz (9.8; 12.4)], p = 0.12. Five minutes after full ECMO initiation MF increased [11.6 Hz (10.6; 13.5)], p = 0.04 (compared to minute 15 of VF) and did not deteriorate during the rest of ECMO treatment. Out of all subjects, three animals did not reach ROSC. Those subjects demonstrated deeper decrease of MF at the VF minute 15 as compared to others [-2.4 Hz (-2.5; −2.3) vs. −0.6 Hz (-1.6; −0.1)] and continuously significantly higher increase in MF on full ECMO support [4.3 Hz (2.9; 5.6) vs. 1.1 Hz (0.6; 1.6)] with p = 0.05 for both observations, respectively. Conclusions The veno-arterial ECMO reperfusion influences MF of VF wavelet obtained from right ventricular apex. The course of changes in wavelet frequency corresponds to a presence of later ROSC.
Studying the Flow Dynamics in an Aortic Endograft with Crossed-limbs
Authors: Georgakarakos Efstratios , Xenakis Antonios , Manopoulos Christos , Georgiadis George S. , Argyriou Christos , Tsangaris Sokrates , Lazarides Miltos K. 
Published: March 2014

Purpose To evaluate the flow phenomena within an aortic endograft with crossed-limbs, comparing to an endograft with the ordinary limb bifurcation. Methods An endograft model with crossed-limbs was computationally reconstructed based on Computed Tomography patient-specific data, using commercially available software. Accordingly, its analogue model was reconstructed in the ordinary fashion (ordinary bifurcation). Computational fluid dynamics analysis was performed to determine and compare the flow fields, velocity profiles, pressure and shear stress distribution throughout the different parts of both endograft configurations, in different phases of the cardiac cycle. Results The flow patterns between the “Ballerina” and the classic endograft were similar, with flow disturbance near the inlet zone at late diastole and smooth flow patterns during the systolic phase. Both configurations presented similar pressure distribution patterns throughout the cardiac cycle. The highest and lowest pressures were demonstrated in the inlet-main body area and the iliac limbs, respectively. Marked differences were observed in the velocity profiles of the proximal limb segments between the two configurations, mostly in the peak- and end-systolic phase. The regions of lower velocities correlated well to low shear values. Differences in the shear stress distribution were noted between the two configurations in the systolic and, predominantly, in the diastolic phase. Conclusions There are differences in the velocity profiles and shear distribution between the limbs of the two endograft configurations. The pathophysiologic implication of our findings and their possible association with clinical events, such as thrombus apposition, deserves further investigation.
Design and Evaluation of a Hybrid Mock Circulatory Loop for total Artificial Heart Testing
Authors: Cuenca-Navalon Elena , Finocchiaro Thomas , Laumen Marco , Fritschi Andreas , Schmitz-Rode Thomas , Steinseifer Ulrich 
Published: March 2014

Aims A hybrid mock circulatory loop (MCL) was developed for total artificial heart (TAH) performance evaluation. The hybrid MCL consists of hydraulic hardware components and a software computer model. Design The hydraulic components are divided into the systemic and pulmonary circulation, each of which includes electrically controlled compliances, resistors, and a venous volume which can be adjusted for a wide range of physiological and pathological conditions. The software model simulates the baroreflex autoregulatory response by automatically adjusting the hydraulic parameters according to changes of condition in the MCL. Results The experimental results demonstrated a good representation of the human cardiovascular system and the capability of real-time variation of physiological and pathological conditions. The functionality of the baroreflex autoregulatory mechanism was evaluated by simulation of a postural change. Conclusions The hybrid MCL that we developed allows variable and continuous in vitro evaluation of mechanical circulatory support devices in TAH configuration and particularly their control algorithms in response to various cardiovascular conditions. The system has been built in a modular configuration to allow testing of different types of devices and thus provides a valuable test platform prior to animal experiments.
L’histoire littéraire du contemporain : l’éternel retour
Authors: Vaillant Alain 
Published: March 2014

L’histoire littéraire du contemporain n’est pas une nouveauté. En fait, on n’a jamais cessé de vouloir faire l’histoire du contemporain, et l’histoire littéraire, dès sa naissance à l’époque romantique, semble avoir été inventée pour penser ce contemporain absolu que paraissait être la littérature postrévolutionnaire. Or on voit bien quels risques épistémologiques fait courir à l’histoire littéraire cette perpétuelle tentation. La question qui se pose aujourd’hui est donc de se demander en quoi le contemporain du xxie siècle se distinguerait de ses avatars du passé et, plus généralement, si le contemporain peut être regardé comme un concept du point de vue de la science historique, ou s’il n’est qu’un mot, servant à la fois à renouveler le vocabulaire critique et à traduire en termes esthétiques (en les masquant du même coup) les transformations de la demande sociale en matière de littérature. Pour éviter un débat où les enjeux idéologiques sont très évidemment prépondérants, je me propose, en historien de la littérature, de comparer trois moments où l’histoire littéraire du contemporain a été le terrain de débats critiques particulièrement vifs et étendus hors de la sphère savante : l’époque romantique, la Troisième République et l’époque actuelle. En substituant une histoire pluriséculaire aux actuelles théories du contemporain, je m’efforcerai de montrer que le contemporain est une notion nodale, à la fois nécessaire et trompeuse, où se cristallisent, à chaque époque, les représentations de la littérature — de son devenir formel comme de son rôle social.
L’historiographie française et le temps présent. Processus de légitimation et remise en question de l’historien
Authors: Walsh Francis 
Published: March 2014

Le présent article a pour but d’éclairer l’apport des réflexions sur la notion de « temps présent » dans l’historiographie française contemporaine et, sans s’y restreindre, principalement celles issues des recherches de l’Institut d’histoire du temps présent fondé par François Bédarida en 1978. Après avoir rapidement brossé un tableau général du contexte épistémologique du second après-guerre, j’y propose trois stades de légitimation de cette pratique historienne controversée (manifeste, bilan et banalisation), stades qui coïncident avec les différents états successifs des arguments en faveur de l’étude du contemporain. Il s’agit donc de montrer comment les défenseurs de l’histoire du temps présent ont pensé l’histoire en prenant position par rapport à l’historiographie générale.
Identité et gouvernance autochtones dans les ententes d’autonomie et de revendications territoriales globales au Canada
Authors: Motard Geneviève 
Published: March 2014

Dans cet article, l’auteure examine les règles d’appartenance retenues dans les ententes d’autonomie gouvernementale et de revendications territoriales globales qui ont recours au principe de personnalité des lois. Dans un régime de personnalité des lois, il est de la prétention de l’auteure que l’identité de la nation signataire des ententes a le potentiel de devenir un enjeu de pouvoir. En effet, l’identité autochtone devient alors une « frontière » du pouvoir entre l’État et la nation autochtone, ce qui encourage l’État à s’intéresser de près aux règles identitaires des nations signataires des ententes. Ce faisant, l’État porte atteinte au droit fondamental des peuples autochtones de s’autodéfinir. Après un bref historique du traitement de l’identité autochtone dans les traités conclus entre l’État et les peuples autochtones, l’auteure présente les dispositifs des ententes ayant pour effet de favoriser l’intervention étatique dans les choix identitaires des nations signataires. Pour finir, l’auteure met en lumière quelques conséquences des choix identitaires effectués dans les ententes sur la gouvernance des nations signataires.
Fraternité, souveraineté et autonomie des Autochtones en Nouvelle-France
Authors: Morin Michel 
Published: March 2014

Aux xviie et xviiie siècles, les principes juridiques encadrant les relations entre les Algonquiens de la vallée du Saint-Laurent et les Français sont généralement bien compris par chacune des parties en présence. Initialement fondés sur les concepts d’amitié, d’alliance ou de fraternité, ces principes postulent l’existence de nations indépendantes possédant leurs propres structures décisionnelles et leurs coutumes, ainsi que de chefs locaux ou régionaux qui jouissent en pratique d’une grande autorité. De 1628 à 1663, le statut de sujet du roi de France est d’ailleurs accordé uniquement aux nouveaux convertis, puis, de 1664 à 1674, à leurs descendants. Par la suite, la situation est ambiguë. Toutefois, les communautés de chrétiens vivant près des villes françaises conservent une grande autonomie à laquelle elles acceptent rarement de renoncer. Elles sont parfois qualifiées d’enfants du roi, parce qu’elles soutiennent inconditionnellement les Français sur le plan militaire. Dans la deuxième moitié du xviie siècle, des nations non converties reconnaissent également le statut de père au roi de France, mais cette dépendance socio-économique et militaire ne remet pas en question leur indépendance, ce que les Français comprennent fort bien.
Familial Loss of a Loved One and Biological Aging
Authors: Aiello Allison E. , Mishra Aura Ankita , Martin Chantel L. , Levitt Brandt , Gaydosh Lauren , Belsky Daniel W. , Hummer Robert A. , Umberson Debra J. , Harris Kathleen Mullan 
Published: July 2024

ImportanceThe link between familial loss of a loved one and long-term health decline is complex and not fully understood.ObjectiveTo test associations of losing a parent, sibling, child, or partner or spouse with accelerated biological aging.Design, Setting, and ParticipantsData from the National Longitudinal Study of Adolescent to Adult Health, a US population-based longitudinal cohort study, were analyzed. Participants were enrolled from 1994 to 1995 for wave 1, while in grades 7 to 12, and followed up through wave 5 in 2018. The study analyzed participant reports of loss collected at each wave from 1 to 5 over 24 years and used a banked wave 5 blood sample for subsequent DNA methylation testing and epigenetic clock calculation from 2018 to 2024. Data were analyzed from January 2022 to July 2024.ExposureLoss of biological parents or parental figures, partners or spouses, siblings, or children at waves 1 to 3 or during childhood, adolescence (aged &amp;lt;18 years), or adulthood at wave 4 to wave 5 (aged 18-43 years).Main Outcomes and MeasuresBiological aging assessed from blood DNA methylation using the Horvath, PhenoAge, GrimAge, and DunedinPACE epigenetic clocks at wave 5.ResultsData from 3963 participants were analyzed, with a weighted mean (range) age of 38.36 (36.78-39.78) years at wave 5; 2370 (50.3%) were male, 720 (15.97%) were Black, 400 (8.18%) were Hispanic, and 2642 (72.53%) were White. Nearly 40% of participants experienced loss by wave 5 when they were aged 33 to 43 years, and participants who were Black (379 participants [56.67%]), Hispanic (152 participants [41.38%]), and American Indian (18 participants [56.08%]) experienced a greater proportion of losses compared with White participants (884 participants [34.09%]). Those who experienced 2 or more losses tended to have older biological ages for several of the clocks (PhenoAge β = 0.15; 95% CI, 0.02 to 0.28; GrimAge β = 0.27; 95% CI, 0.09 to 0.45; DunedinPACE β = 0.22; 95% CI, 0.10 to 0.34) compared with those with no losses. In contrast, there were no associations with 2 or more losses for the Horvath clock (β = −0.08; 95% CI, −0.23 to 0.06).Conclusions and RelevanceThis study reveals associations between various measures of loss experienced from childhood to adulthood and biological aging in a diverse sample of the US population. These findings underscore the potentially enduring impact of loss on biological aging even before middle age and may contribute to understanding racial and ethnic disparities in health and mortality.
Fecal Microbiota Transplantation for Treatment of Parkinson Disease
Authors: Scheperjans Filip , Levo Reeta , Bosch Berta , Lääperi Mitja , Pereira Pedro A. B. , Smolander Olli-Pekka , Aho Velma T. E. , Vetkas Nora , Toivio Lotta , Kainulainen Veera , Fedorova Tatyana D. , Lahtinen Perttu , Ortiz Rebekka , Kaasinen Valtteri , Satokari Reetta , Arkkila Perttu 
Published: July 2024

ImportanceDysbiosis has been robustly demonstrated in Parkinson disease (PD), and fecal microbiota transplantation (FMT) has shown promising effects in preclinical PD models.ObjectiveTo assess the safety and symptomatic efficacy of colonic single-dose anaerobically prepared FMT.Design, Setting, and ParticipantsThis was a double-blind, placebo-controlled, randomized clinical trial conducted between November 2020 and June 2023 with a follow-up period of 12 months at 4 hospitals in Finland. Patients with PD aged 35 to 75 years in Hoehn &amp;amp; Yahr stage 1-3 with a mild to moderate symptom burden and dysbiosis of fecal microbiota were included. Of 229 patients screened, 48 were randomized and 47 received the intervention. One patient discontinued due to worsening of PD symptoms. Two further patients were excluded before analysis and 45 were included in the intention-to-treat analysis.InterventionParticipants were randomized in a 2:1 ratio to receive FMT or placebo via colonoscopy.Main Outcomes and MeasuresThe primary end point was the change of Movement Disorder Society Unified Parkinson’s Disease Rating Scale parts I-III (part III off medication) at 6 months. Safety was assessed by recording adverse events (AEs).ResultsThe median (IQR) age was 65 (52.5-70.0) years in the placebo group and 66 (59.25-69.75) years in the FMT group; 9 (60.0%) and 16 (53.3%) patients were male in the placebo group and the FMT group, respectively. The primary outcome did not differ between the groups (0.97 points, 95% CI, −5.10 to 7.03, P = .75). Gastrointestinal AEs were more frequent in the FMT group (16 [53%] vs 1 [7%]; P = .003). Secondary outcomes and post hoc analyses showed stronger increase of dopaminergic medication and improvement of certain motor and nonmotor outcomes in the placebo group. Microbiota changes were more pronounced after FMT but differed by donor. Nevertheless, dysbiosis status was reversed more frequently in the placebo group.Conclusions and RelevanceFMT was safe but did not offer clinically meaningful improvements. Further studies—for example, through modified FMT approaches or bowel cleansing—are warranted regarding the specific impact of donor microbiota composition and dysbiosis conversion on motor and nonmotor outcomes as well as medication needs in PD.Trial RegistrationClinicalTrials.gov Identifier: NCT04854291
α‐Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis
Authors: Xue Yibin , Parsad Arjuna , Dong Guangbin 
Published: July 2024

AbstractThis chapter presents the procedure for α‐arylation of cyclopentanones by palladium/enamine cooperative catalysis. The procedures inOrganic Synthesesare intended for use only by persons with proper training in experimental organic chemistry. Among various ketone functionalization strategies, the Buchwald–Hartwig–Miura (BHM) arylation has been a widely used approach for α‐arylation of ketones via transition metal‐catalyzed cross‐couplings with aryl halides. However, simple or less substituted cyclopentanones have been very difficult substrates for the BHM reaction, attributed to the side reaction of cyclopentanones under strong basic conditions. To address the challenge of α‐arylation of cyclopentanones, a new strategy based on the palladium/enamine cooperative catalysis was developed in 2016. Good site‐selectivity was observed with the α‐substituted cyclopentanones, favoring arylation at the less sterically hindered side. Therefore, this reaction could represent a general method for mono‐α‐arylation of cyclopentanones.