bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical applications of generative artificial intelligence in radiology: image translation, synthesis, and text generation
Authors: Zhong Zhiqi , Xie Xueqian 
Published: August 2024

Abstract
Generative artificial intelligence (AI) has enabled tasks in radiology, including tools for improving image quality. Recently, new hotspots have emerged, such as intra- or inter-modal image translation, task-specific image synthesis, and text generation. Advances in generative AI have facilitated the move towards low-dose, cost-effective, and high-quality radiological image acquisition. Large language models can aid radiologists by generating professional answers and facilitating patient-physician communications. However, radiologists must be aware of potential inaccuracies in the generated content and should only use such tools after rigorous validation of their performance.
Sodium glucose co-transporter 2 inhibitors in the treatment of glomerular diseases: a CKJ controversy
Authors: Caravaca-Fontán Fernando , del Vecchio Lucia , Praga Manuel , Floege Jürgen , Zoccali Carmine 
Published: August 2024

ABSTRACT
Integrating sodium-glucose co-transporter 2 inhibitors (SGLT2i) into the treatment for chronic kidney disease (CKD) has marked a significant therapeutic advance in nephrology. Clinical trials such as DAPA-CKD and EMPA-KIDNEY have demonstrated the beneficial effects of SGLT2i in slowing CKD progression and reducing proteinuria. However, the applicability of these results to patients with glomerulonephritis is still unresolved due to various limitations. This manuscript combines the evidence supporting the use of SGLT2i in glomerular diseases, highlights the limitations and strikes a conclusive balance on their role in clinical practice.
Interactive effects of sedimentary turbidity and elevated water temperature on the Pugnose Shiner (Miniellus anogenus), a threatened freshwater fish
Authors: Fortin-Hamel Liana , Chapman Lauren J 
Published: August 2024

Abstract
High turbidity and elevated water temperature are environmental stressors that can co-occur in freshwater ecosystems such as when deforestation increases solar radiation and sedimentary runoff. However, we have limited knowledge about their combined impacts on fish behaviour and physiology. We explored independent and interactive effects of sedimentary turbidity and temperature on the swimming activity and both thermal and hypoxia tolerance of the Pugnose Shiner (Miniellus anogenus, formerly Notropis anogenus), a small leuciscid fish listed as Threatened under Canada’s Species at Risk Act (SARA). Fish underwent a 15-week acclimation to two temperatures (16°C or 25°C) crossed with two turbidities (~0 NTU or 8.5 NTU). Swimming activity was measured during the first 8 weeks of acclimation. Fish in warm water were more active compared to those in cold water, but turbidity had no effect on activity. Behavioural response to hypoxia was measured after 12 weeks of acclimation, as the oxygen level at which fish used aquatic surface respiration (ASR). Fish in warm water engaged in ASR behaviour at higher oxygen thresholds, indicating less tolerance to hypoxia. Turbidity had no effect on ASR thresholds. Finally, thermal tolerance was measured as the critical thermal maximum (CTmax) after 13–15 weeks of acclimation. Acclimation to warm water increased fish CTmax and Tag (agitation temperature) but reduced the agitation window (°C difference between Tag and CTmax) and thermal safety margin (°C difference between the acclimation temperature and CTmax). Furthermore, fish in warm, turbid water had a lower CTmax and smaller thermal safety margin than fish in warm, clear water, indicating an interaction between turbidity and temperature. This reduced thermal tolerance observed in Pugnose Shiner in warm, turbid water highlights the importance of quantifying independent and interactive effects of multiple stressors when evaluating habitat suitability and conservation strategies for imperilled species.
To live or let die? Epigenetic adaptations to climate change—a review
Authors: Zetzsche Jonas , Fallet Manon 
Published: August 2024

Abstract
Anthropogenic activities are responsible for a wide array of environmental disturbances that threaten biodiversity. Climate change, encompassing temperature increases, ocean acidification, increased salinity, droughts, and floods caused by frequent extreme weather events, represents one of the most significant environmental alterations. These drastic challenges pose ecological constraints, with over a million species expected to disappear in the coming years. Therefore, organisms must adapt or face potential extinctions. Adaptations can occur not only through genetic changes but also through non-genetic mechanisms, which often confer faster acclimatization and wider variability ranges than their genetic counterparts. Among these non-genetic mechanisms are epigenetics defined as the study of molecules and mechanisms that can perpetuate alternative gene activity states in the context of the same DNA sequence. Epigenetics has received increased attention in the past decades, as epigenetic mechanisms are sensitive to a wide array of environmental cues, and epimutations spread faster through populations than genetic mutations. Epimutations can be neutral, deleterious, or adaptative and can be transmitted to subsequent generations, making them crucial factors in both long- and short-term responses to environmental fluctuations, such as climate change. In this review, we compile existing evidence of epigenetic involvement in acclimatization and adaptation to climate change and discuss derived perspectives and remaining challenges in the field of environmental epigenetics.
Graphical Abstract
Desmoplakin cardiomyopathy: case report
Authors: Helal Ayman , Alama Mohamed , Ali Wael , Farooq Mohsen 
Published: August 2024

Abstract

Background
Desmoplakin (DSP) cardiomyopathy is a distinct form of cardiomyopathy characterized by frequent left ventricular involvement with extensive fibrosis, high arrhythmic risk, and episodes of acute myocardial injury.

Case summary
We are reporting diagnosis and management of a rare case of DSP cardiomyopathy. A patient in his 70s was investigated for mild shortness of breath, recurrent chest infection, and multiple ventricular ectopic. His echocardiogram showed impaired systolic function and found to have 53% ectopic burden with run of non-sustained ventricular tachycardia on 24 h electrocardiogram. Cardiac magnetic resonance imaging showed findings highly suggestive of DSP cardiomyopathy. High-resolution computed tomography chest suggested connective tissue–related interstitial lung disease. The diagnosis of DSP cardiomyopathy was confirmed by genetic testing that demonstrated mutation in DSP protein. The patient had implantable cardioverter-defibrillator implantation for primary prevention.

Discussion
Implantable cardioverter-defibrillator implantation should be considered with left ventricular ejection fraction thresholds &gt;35%, particularly in the presence of additional risk factors.
Colchicine for cardiovascular and limb risk reduction in Medicare beneficiaries with peripheral artery disease: emulation of target trials
Authors: Heindel Patrick , Fitzgibbon James J , Secemsky Eric , Bhatt Deepak L , Al-Omran Mohammed , Verma Subodh , Almaghlouth Ibrahim A , Madenci Arin , Hussain Mohamad A 
Published: August 2024

Abstract

Aims
Recent evidence from randomized trials demonstrates that colchicine can reduce the risk of major adverse cardiovascular events (MACE) in patients with coronary artery disease. Colchicine’s effect on lower-extremity peripheral artery disease (PAD) is not known.

Methods and results
To make inferences about the real-world effectiveness of colchicine in PAD, we emulated two target trials leveraging the variable prescribing practice of adding colchicine vs. a non-steroidal anti-inflammatory drug (NSAID) to urate-lowering therapy in patients with gout and PAD. Emulated Trial 1 compared colchicine initiators with NSAID initiators. Emulated Trial 2 compared long-term (indefinite) and short-term (3 months) treatment strategies after initiating colchicine. Eligible individuals were those continuously enrolled in Medicare receiving care at a multicentre academic health system between July 2007 and December 2019. The primary outcome for both trials was a 2 year composite of major adverse limb events (MALE), MACE, and all-cause mortality. Secondary outcomes included MALE and death, MACE and death, and individual components of the primary outcome. Inverse probability weighting was used to adjust for confounding. Percentile-based 95% confidence intervals (CIs) were estimated using non-parametric bootstrapping. A total of 1820 eligible patients were included; the mean age was 77 years [standard deviation (SD) 7], 32% were female, and 9% were non-White. The mean (SD) duration of colchicine and NSAID therapy was 247 (345) and 137 (237) days, respectively. In the emulation of Trial 1, the risk of the primary composite outcome of MALE, MACE, and death at 2 years was 29.9% (95% CI 27.2%, 32.3%) in the colchicine group and 31.5% (28.3%, 34.6%) in the NSAID group, with a risk difference of −1.7% (95% CI −6.5%, 3.1%) and a risk ratio of 0.95 (95% CI 0.83, 1.07). Similar findings were noted in the emulation of Trial 2, with a risk of the primary composite outcome at 2 years of 30.7% (95% CI 23.7%, 38.1%) in the long-term colchicine group and 33.4% (95% CI 29.4%, 37.7%) in the short-term group, with a risk difference of −2.7% (95% CI −10.3%, 5.4%) and risk ratio of 0.92 (95% CI 0.70, 1.16).

Conclusion
In a real-world sample of patients with PAD and gout, estimates of the effect of colchicine were consistent across two analyses and provided no conclusive evidence that colchicine decreased the risk of adverse cardiovascular or limb events and death. The cardiovascular and limb benefits of colchicine in older, comorbid populations with PAD and advanced systematic atherosclerosis remain uncertain.
Development and Validation of Physical Disability Index and Mental Disability Index and Their Associations With Falls Among Older Adults
Authors: Zhang Xuxi , Sun Xinying , Yin Pengbin , Zhang Licheng , Tang Peifu , Zeng Yi 
Published: August 2024

Abstract

Background
To enhance the precision of measuring, analyzing, and forecasting care needs for older adults with physical and/or mental disabilities, we developed the Physical Disability Index (PDI) and Mental Disability Index (MDI). Furthermore, we evaluated the reliability and validity of the PDI and MDI. Additionally, we investigate their associations with falls to further indicate the predictive validity.

Methods
A total of 11 621 older adults (53.1% women; mean age = 83.2; SD = 10.8) from 23 provinces in China were investigated in 2017–2018 to assess the reliability and validity of the PDI and MDI among older adults aged 65 to 105. Among which, 6 071 older adults with both baseline (2017–2018) and follow-up (2021) data were included in analyses to evaluate associations between the baseline health status determined by PDI and MDI and the number and severity of falls at baseline and follow-up. Cronbach’s alpha was used to determine internal consistency. The convergent and divergent validity, known-group validity and concurrent validity were assessed. Multinomial logistic regression models were utilized to assess associations.

Results
We found satisfactory internal consistency (Cronbach’s alpha ≥ 0.70) of the PDI and MDI in the total sample and sex-specific subgroups. Our results support the convergent and divergent validity, known-group validity, and concurrent validity of the PDI and MDI. We also found baseline physical disability and comorbid physical and mental disability are associated with a higher risk of baseline and follow-up falls.

Conclusions
The PDI and MDI are reliable and valid instruments to assess physical and mental disability status among older adults, respectively.
New Law Responding to Imitations of Designs that Intersect Real and Virtual Space: Amendment of the Unfair Competition Prevention Act in Japan
Authors: Komada Yasuto 
Published: August 2024

Abstract
Digital items that have the appearance of real utilitarian products are often tied to NFTs (Non-Fungible Tokens) in the virtual space known as the metaverse, and sold as goods. The designs of real utilitarian products are increasingly being converted into the designs of such NFT goods without the permission of their developers. In order to deal with these imitations, which intersect the real and the virtual worlds, the Japanese legislator decided to utilize the existing provision for the protection of forms of goods in the unfair competition prevention law (UCPA 1993). The law was amended in June 2023 to newly define ‘the act of offering through telecommunication line’ goods that imitate the form of another person’s goods as an act of unfair competition.
Copyright protection under Japanese case law has rarely been granted to designs of utilitarian products, and under Japanese design law the product design is identified not only by its shape but also by its product type. The protection of image designs is almost exclusively limited to specific images unrelated to the NFT goods. However, the revised provision of UCPA 1993 has also been generally interpreted as the provision prohibiting the imitation of designs between homogeneous products. The amendment effectively negates this interpretation.
This paper reveals the impact on the existing interpretation of the relevant provision of UCPA 1993 and the issues arising from other legal provisions with respect to such imitations.
Genotype-associated core bacteria enhance host resistance against kiwifruit bacterial canker
Authors: Fu Min , Chen Yunhe , Liu Yong-Xin , Chang Xiaoxi , Zhang Lei , Yang Xinyi , Li Li , Zhang Lixin 
Published: August 2024

Abstract
Both the phyllosphere and rhizosphere are inhabited by different kinds of microorganisms that are closely related to plant growth and health. However, it is not clear whether disease-resistant cultivars shape the microbiome to facilitate disease resistance. In this study, significant differences were found in the aboveground and belowground bacterial communities of disease-resistant and disease-susceptible cultivars grown in the same kiwifruit orchard. The phyllosphere of the resistant cultivar ‘Wanjin’ showed greater enrichment of Pseudomonas spp. and Sphingomonas spp. than the susceptible cultivar ‘Donghong’. The rhizosphere microbes of ‘Wanjin’ were less affected by field location, with significantly greater bacterial abundance than those of ‘Donghong’ and more bacteria with potential biocontrol properties. Pseudomonas syringae pv. actinidiae (Psa) infection significantly affected the microbiome of the phyllosphere of kiwifruit plants, especially that of ‘Donghong’. Resistant and susceptible kiwifruit cultivars exhibit distinct beneficial microbial recruitment strategies under Psa challenge. The phyllosphere of ‘Donghong’ in Jinzhai was enriched with Sphingomonas spp. and Pantoea spp. under Psa infection, while the rhizosphere of ‘Wanjin’ was enriched with Sphingomonas spp. and Novosphingobium spp. We further identified five key biomarkers within the microbial community associated with Psa infection. Inoculation experiments showed that Lysobacter sp. R34, Stenotrophomonas sp. R31, Pseudomonas sp. R10 and RS54, which were isolated from belowground compartments of ‘Wanjin’, could positively affect plant performance under Psa challenge. The combination use of Pseudomonas sp. R10 and Stenotrophomonas sp. R31 significantly improve the management of kiwifruit canker. Our findings provided novel insights into soil–microbe–plant interactions and the role of microbes in plant disease resistance and susceptibility.
Generalized kernel distance covariance in high dimensions: non-null CLTs and power universality
Authors: Han Qiyang , Shen Yandi 
Published: August 2024

Abstract
Distance covariance is a popular dependence measure for two random vectors $X$ and $Y$ of possibly different dimensions and types. Recent years have witnessed concentrated efforts in the literature to understand the distributional properties of the sample distance covariance in a high-dimensional setting, with an exclusive emphasis on the null case that $X$ and $Y$ are independent. This paper derives the first non-null central limit theorem for the sample distance covariance, and the more general sample (Hilbert–Schmidt) kernel distance covariance in high dimensions, in the distributional class of $(X,Y)$ with a separable covariance structure. The new non-null central limit theorem yields an asymptotically exact first-order power formula for the widely used generalized kernel distance correlation test of independence between $X$ and $Y$. The power formula in particular unveils an interesting universality phenomenon: the power of the generalized kernel distance correlation test is completely determined by $n\cdot \operatorname{dCor}^{2}(X,Y)/\sqrt{2}$ in the high-dimensional limit, regardless of a wide range of choices of the kernels and bandwidth parameters. Furthermore, this separation rate is also shown to be optimal in a minimax sense. The key step in the proof of the non-null central limit theorem is a precise expansion of the mean and variance of the sample distance covariance in high dimensions, which shows, among other things, that the non-null Gaussian approximation of the sample distance covariance involves a rather subtle interplay between the dimension-to-sample ratio and the dependence between $X$ and $Y$.
Rank Zero Segre Integrals on Hilbert Schemes of Points on Surfaces
Authors: Yuan Yao 
Published: August 2024

Abstract
The generating function of the Segre integrals on Hilbert schemes of points on a surface $X$ can be determined by five universal series $A_{0}(z)$, $A_{1}(z)$, $A_{2}(z)$, $A_{3}(z)$, $A_{4}(z)$, due to the result of Ellingsrud–Göttsche–Lehn. These five series do not depend on the surface $X$ and depend on the element $\alpha \in K(X)$, to which the Segre integrals are associated, only through the rank. Marian–Oprea–Pandharipande have determined $A_{0}(z),A_{1}(z),A_{2}(z)$ for all ranks. For rank 0, it is easy to see $A_{4}(z)=1$. Marian–Oprea–Pandharipande also conjectured that $A_{3}(z)=A_{0}(z)A_{1}(z)$ for rank 0. We prove this conjecture by showing that when $X$ is the projective plan, the Segre integrals associated to the structure sheaf of a curve in the anti-canoncial class are all zero. Hence, the rank zero Segre integrals on the Hilbert schemes of points for all surfaces are determined.
Disguise or surprise: spider antipredator adaptations as a function of the architecture of their webs
Authors: Haberkern Andrea M , Boles Jessica C , Zhou Yi Lin , Camacho Luis F , Brescovit Antonio D , Avilés Leticia 
Published: August 2024

Abstract
Animals exhibit a variety of strategies to avoid predation; spiders are no exception. We explored whether web-building spiders that differ in the architecture of their webs exhibit morphologies or behaviors suggestive of antipredator strategies that trade-off with the degree of protection offered by their webs. Spiders build webs of 3 types: the more protected tangles and sheet-and-tangles, which are three-dimensional (3D), and the more exposed orbs, which are two-dimensional (2D), both with or without a refuge. We hypothesize that spiders whose webs offer greater protection—a 3D architecture or a refuge—will be less likely to be armored or brightly colored when compared to spiders without these protections. We collected data on 446 spiders and their webs in 2 lowland tropical rainforest sites. We show that 2D web builders with no refuges tended to be brightly colored (background contrasting) and spiny (spiky), whereas those with refuges tended to blend against the background of their refuges. 3D web builders, on the other hand, were neither cryptic nor brightly colored nor armored but were more likely to drop out of the web upon simulated predator contact. These results support the hypothesis that web-building spiders tend to be protected either through the architecture of their webs or their morphology and behavior, suggesting a trade-off between different types of antipredator strategies.
Mass Attitudes about International Trade Agreements: Positive Messages and the Trans-Pacific Partnership
Authors: Bearce David H , Park Seungbin 
Published: August 2024

Abstract
From the understanding that the mass public knows little about the benefits of international trade agreements but nonetheless opposes them with opposition representing a problem for domestic ratification, this research note explores if and what messages about the Trans-Pacific Partnership might increase popular support. The experimental results show that providing more background information alone does not increase support, but adding an economic message about how this agreement could lower prices or a security message about how it would help the United States counter China increases support. The economic message also encourages respondents to write a statement to their Senators urging them to vote for ratification. These positive effects appear even within groups that are more opposed, namely less educated citizens and Republicans. Our results address important questions about the formation of trade policy preferences, showing they can be shifted in directions contrary to one's egocentric interests and partisan predispositions.
Designing the Australian Cancer Atlas: visualizing geostatistical model uncertainty for multiple audiences
Authors: Goodwin Sarah , Saunders Thom , Aitken Joanne , Baade Peter , Chandrasiri Upeksha , Cook Dianne , Cramb Susanna , Duncan Earl , Kobakian Stephanie , Roberts Jessie , Mengersen Kerrie 
Published: August 2024

Abstract

Objective
The Australian Cancer Atlas (ACA) aims to provide small-area estimates of cancer incidence and survival in Australia to help identify and address geographical health disparities. We report on the 21-month user-centered design study to visualize the data, in particular, the visualization of the estimate uncertainty for multiple audiences.

Materials and Methods
The preliminary phases included a scoping study, literature review, and target audience focus groups. Several methods were used to reach the wide target audience. The design and development stage included digital prototyping in parallel with Bayesian model development. Feedback was sought from multiple workshops, audience focus groups, and regular meetings throughout with an expert external advisory group.

Results
The initial scoping identified 4 target audience groups: the general public, researchers, health practitioners, and policy makers. These target groups were consulted throughout the project to ensure the developed model and uncertainty visualizations were effective for communication. In this paper, we detail ACA features and design iterations, including the 3 complementary ways in which uncertainty is communicated: the wave plot, the v-plot, and color transparency.

Discussion
We reflect on the methods, design iterations, decision-making process, and document lessons learned for future atlases.

Conclusion
The ACA has been hugely successful since launching in 2018. It has received over 62 000 individual users from over 100 countries and across all target audiences. It has been replicated in other countries and the second version of the ACA was launched in May 2024. This paper provides rich documentation for future projects.