bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug-Related Pneumonitis During Mammalian Target of Rapamycin Inhibitor Therapy: Radiographic Pattern-Based Approach in Waldenström Macroglobulinemia as a Paradigm
Authors: Nishino Mizuki , Boswell Erica N. , Hatabu Hiroto , Ghobrial Irene M. , Ramaiya Nikhil H. 
Published: July 2015

Abstract

Background.
This study determined the frequency of drug-related pneumonitis during mammalian target of rapamycin (mTOR) inhibitor therapy in Waldenström macroglobulinemia patients and investigated the imaging characteristics and radiographic patterns of pneumonitis.

Materials and Methods.
A total of 40 patients (23 men, 17 women; 43–84 years old) with Waldenström macroglobulinemia treated in 2 trials of the mTOR inhibitor everolimus were retrospectively studied. Chest computed tomography (CT) scans during therapy were reviewed for abnormalities suspicious for drug-related pneumonitis by the consensus of three radiologists, evaluating the extent, distributions, and specific findings. The radiographic patterns of pneumonitis were classified using the American Thoracic Society/European Respiratory Society classification of interstitial pneumonia.

Results.
Drug-related pneumonitis was noted in 23 patients (58%). The median time from the initiation of therapy to the onset of pneumonitis was 5.7 months. Lower lungs were involved in all 23 patients, with a higher extent than in the other zones (p &lt; .001). The distribution was peripheral and lower in 11 patients (48%) and mixed and multifocal in 10 (44%). The findings were bilateral in 20 patients (87%). Ground glass opacities (GGOs) and reticular opacities were present in all 23 patients, with consolidation in 12, traction bronchiectasis in 2, and centrilobular nodularity in 1. The pattern of pneumonitis was classified as cryptogenic organizing pneumonia (COP) in 16 (70%) and nonspecific interstitial pneumonia (NSIP) in 7 (30%), with overlapping features of COP and NSIP in 7 patients.

Conclusion.
Drug-related pneumonitis was noted on CT in 58% of Waldenström macroglobulinemia patients treated with mTOR inhibitor therapy. Most common findings were bilateral GGOs and reticular opacities, with or without consolidation, in peripheral and lower lungs, demonstrating COP and NSIP patterns.

Implications for Practice:
The present study has demonstrated that drug-related pneumonitis during mammalian target of rapamycin (mTOR) inhibitor therapy is highly frequent, occurring in 58% of patients with Waldenström macroglobulinemia. The radiographic patterns of pneumonitis demonstrated cryptogenic organizing pneumonia and nonspecific interstitial pneumonia patterns, with overlapping features in 30% of the patients. The present study describes an initial attempt of a radiographic pattern-based approach to drug-related pneumonitis in the era of molecular targeting therapy, with a cohort of patients with Waldenström macroglobulinemia receiving mTOR inhibitor therapy as a paradigm, which might contribute to further understanding and in-depth interpretation of lung toxicity during novel cancer therapy.
Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth-Hitchcock Medical Center
Authors: Tafe Laura J. , Gorlov Ivan P. , de Abreu Francine B. , Lefferts Joel A. , Liu Xiaoying , Pettus Jason R. , Marotti Jonathan D. , Bloch Kasia J. , Memoli Vincent A. , Suriawinata Arief A. , Dragnev Konstantin H. , Fadul Camilo E. , Schwartz Gary N. , Morgan Clinton R. , Holderness Britt M. , Peterson Jason D. , Tsongalis Gregory J. , Miller Todd W. , Chamberlin Mary D. 
Published: July 2015

Abstract

Background.
Although genetic profiling of tumors is a potentially powerful tool to predict drug sensitivity and resistance, its routine use has been limited because clinicians are often unfamiliar with interpretation and incorporation of the information into practice. We established a Molecular Tumor Board (MTB) to interpret individual patients’ tumor genetic profiles and provide treatment recommendations.

Patients and Methods.
DNA from tumor specimens was sequenced in a Clinical Laboratory Improvement Amendments-certified laboratory to identify coding mutations in a 50-gene panel (n = 34) or a 255-gene panel (n = 1). Cases were evaluated by a multidisciplinary MTB that included pathologists, oncologists, hematologists, basic scientists, and genetic counselors.

Results.
During the first year, 35 cases were evaluated by the MTB, with 32 presented for recommendations on targeted therapies, and 3 referred for potential germline mutations. In 56.3% of cases, MTB recommended treatment with a targeted agent based on evaluation of tumor genetic profile and treatment history. Four patients (12.5%) were subsequently treated with a MTB-recommended targeted therapy; 3 of the 4 patients remain on therapy, 2 of whom experienced clinical benefit lasting &gt;10 months.

Conclusion.
For the majority of cases evaluated, the MTB was able to provide treatment recommendations based on targetable genetic alterations. The most common reasons that MTB-recommended therapy was not administered stemmed from patient preferences and genetic profiling at either very early or very late stages of disease; lack of drug access was rarely encountered. Increasing awareness of molecular profiling and targeted therapies by both clinicians and patients will improve acceptance and adherence to treatments that could significantly improve outcomes.

Implications for Practice:
Case evaluation by a multidisciplinary Molecular Tumor Board (MTB) is critical to benefit from individualized genetic data and maximize clinical impact. MTB recommendations shaped treatment options for the majority of cases evaluated. In the few patients treated with MTB-recommended therapy, disease outcomes were positive and support genetically informed treatment.
PROBLEMS IN ASSESSING EPISTEMIC AUTHORITY OF UNIVERSITY PROFESSORS
Authors: Blumberga Solveiga , Vorobjovs Aleksejs 
Published: July 2015

<p>The authors provides reasons for the significance of assessment of epistemic authority of university professors, explicates the concept of epistemic authority and the issues related to research into this concept. In English, epistemic or <a href="http://lv.w3dictionary.org/index.php?q=epistemological">epistemological</a> means “of, relating to, or involving knowledge; cognitive”. An epistemic authority is a source of information who has a determining role in the process knowledge formation (Kruglanski, 1989). Authors analysed conceptual approaches to problems related to assessment of epistemic authority of university professors and to expand on the explanations to the problems in view of the results of the research study on student-perceived epistemic authority of university professors. The article includes the results of students (N=152) and graduates (N=210) of institutions of higher education located in Riga (Latvia). </p>
Differences in Student Reading Competence at Different Age Periods
Authors: Malahova Ludmila , Budviķe Inta , Boge Iveta 
Published: July 2015

<p>Development of modern technologies has affected peoples’ reading competence, as a reader today reads not only printed texts in books, magazines and newspapers, but more and more uses texts from the Internet or hypertexts which require new reading strategies. Considering this, we found out, how these changes have affected students’ reading competence at different age periods, in order to use the obtained information for further development of foreign language study courses. </p>
The competence and Professional practice of supervisor in Latvia : the results of pilotsurvey
Authors: Mārtinsone Kristīne , Mihailova Sandra , Mihailovs Ivans Jānis 
Published: July 2015

<p>Supervision today is gradually becoming a component or compulsory part of professional practice un studies, especially in areas where the focus is a person, psychology, art-therapies, social work, psychoterapy, as well as civil service, pedagogy etc.Supervision is process, where is being reflected on the challenges facing both the client or patient and of the relationship that occurs between staff and clients or patients, both for the specialist are able to comply with the requirements of professional, ethical, as well as the difficulties in dealing with clients patients.Aim of the paper is to present the results of pilot stud (survey)y, how supervision of our country (Latvia) understand the various professions and how supervision in our country is being implemented supervision’s practice in various professional fields.The article highlights the issue of supervisor education problems in Latvia, analyzing the current situation and the legal framework, which is a prerequisite for quality supervision system in the country.</p><p> </p>
The Role of Folk Pedagogy in Child Raising and in Maintaining National Identity in the Latvian Villages of Siberia
Authors: Antiņa Ināra 
Published: July 2015

<p>A large number of Latvia’s inhabitants have left the country recently due to a variety of reasons. There have been several waves of emigration in Latvia’s history. Generations of Latvians live in different parts of the world. Many have become assimilated in their country of destination, but there are communities of Latvians that have maintained their national and cultural identity, as well as traditions for well over a century. The goal of this study is to identify the set of skills, situations and character education – known as folk pedagogy - that are central to the retention of the Latvian idenity in the Latvian villages of Augšbebi (Bobrovka) and Kurzemes Ozolaine (Kurļanddubovka) in the Russian region of Omsk in Siberia.</p><p>An understanding of folk education is particularly relevant in this period of regional mobility, when many people are leaving Latvia, finding themselves new places of residence and trying to maintain their ethnic identity. </p>
Prólogo, posfácio e notas: O projeto nacional em Iracema
Authors: Boechat Maria Cecília 
Published: July 2015

Este artigo se propõe a discutir a interpretação tradicional do nacionalismo literário em Iracema, de José de Alencar, a partir das relações entre o prólogo, o posfácio e as notas do autor – elementos aparentemente acessórios – e a narrativa.<p> </p><p>Cet article se propose à discuter l’interprétation tradicionnelle du nationalisme littéraire dans Iracema, de José de Alencar. A ce propos, on étudie les relations entre des élements textuels apparemment accesoires (prologue, postface et notes) et le récit.</p>
Loucura e morte em "Sorôco, sua mãe, sua filha", de José Saramago
Authors: Belo Fábio Roberto Rodrigues 
Published: July 2015

<p>O presente trabalho tem como objetivo analisar os temas da loucura e da morte, no conto “Sorôco, sua mãe, sua filha”, do livro <em>Primeiras Estórias, de João Guimarãe</em>s Rosa. <strong> </strong></p> <p><strong> </strong></p><p>This work has the aim to analyse the subjects of madness and death, in the tale “Sorôco, sua mãe, sua filha”, by João Guimarães Rosa’s book Primeiras Histórias.</p><p> </p><p> </p>
JOAQUIM MANUEL MAGALHÃES: O EROS SEM MÁSCARAS
Authors: Silva Míriam Soares 
Published: July 2015

<p>Análise de aspectos básicos da poética de Joaquim Manuel Magalhães; em especial, da visibilidade homoerótica e dos efeitos dela decorrentes. An analysis of basic aspects of the poetics of Joaquim Manuel Magalhães; especially regarding homoerotic visibility and the effects which result from it. Este trabalho examina representações do amor em poemas de Álvares de Azevedo. A intenção é observar as formas de representação da mulher, marcadas por diferentes níveis de aceitação social. Considerando os preconceitos tradicionais brasileiros, procuramos interpretar o tratamento dado essa representação em termos de uma posição ambivalente quanto ao idealismo dominante no período.</p> <p>This article examines images of love in Álvares de Azevedo‘s poems. We try to understand the women figures, with their different social levels. Considering brazilian traditional prejudices, we try to evaluate this representation, as an ambivalent position, beyond romantic idealism.</p>
As cicatrizes da história e do mito em O Guarani
Authors: Silva Evaldo Balbino da 
Published: July 2015

<p>Este artigo busca analisar, através do romance <em>O Guarani</em>, de José de Alencar, como mito e História coexistem nas malhas textuais da literatura romântica.</p> <p>Este artículo pretende analizar, utilizando el libro <em>O Guarani</em>, de José de Alencar, como mito e Historia coexisten en las mallas textuales de la literatura romántica.</p> <p> </p>
Da lingüística à literatura: a segunda pessoa em Michaëlis de Vasconcelos e em Nemésio
Authors: Cook Manuela 
Published: July 2015

<p>No estudo de formas de tratamento, impôem-se dois aspectos distintos que, não obstante, se entrelaçam no acto de comunicação: o significado de teor social e o mecanismo morfo-sintáctico que lhe serve de veículo lingüístico. A língua portuguesa goza de uma rica gama de opções, em parte devido à existência de dois sistemas para a segunda pessoa: um recebido directamente do latim, e outro de estabelecimento mais tardio. Este último é hoje o sistema dominante. No entanto, as formas antigas ainda exercem um certo fascínio. Elas são usadas para casos especiais, os quais incluem a expressão de relacionamento de intimidade.Apresente discussão baseia-se num conjunto de versos quinhentistas e mais antigos, analisados pela filóloga Carolina Michaëlis de Vasconcelos, e numa célebre composição poética que foi escrita por Vitorino Nemésio na segunda metade do século vinte.</p> <p> </p> <p>The study of forms of addrcss requires a rwo-fold approach. In question are two distinct facets which, however, become intertwined in the act of communication: the social production of meaning and the morphosyntactic mechanism through which it is constructed. The Portuguese language enjoys a rich range of options, partly due to its two systems for the second person: one received directly from Latin and a subsequent system. Today the latter is the dominant one. Nevertheless, the old forms still exert a certain fascination. They are used for special cases, which include the conveying of intimacy. This discussion is based on a set of poetic lines dating back to the sixteenth century and earlier, which were analysed by philologist Carolina Michaélis de Vasconcelos, and on a celcbrated põem written by Vitorino Nemésio in the second half of the rwentieth century.</p>
O "elemento feminino" na memória de Portugal: Murilo Mendes e Vieira da Silva
Authors: Pereira Maria Luiza Scher 
Published: July 2015

<p>Este trabalho apresenta um aspecto da pesquisa sobre a presença de traços do arquivo cultural português na obra de Murilo Mendes. Pretende-se observar como o elemento feminino, presente na poesia de Murilo, funciona na representação de Portugal, no texto memória/relato de viagem do livro <strong>Janelas Verdes. </strong>A partir disso, observa-se ainda como Lisboa é representada por Vieira da Silva, num semelhante processo de acionamento da memória, em quadros produzidos no seu período de exílio no Rio de Janeiro.</p> <p> </p> <p>This paper discusses an aspect of the research into the presence of certain features of Portuguese cultural archives in the work of Murilo Mendes. Our aim is to examine how the female element, present in Murilo's poetry, works out in the representation of Portugal, in the text from the book <strong>Janelas Verdes, </strong>considered as both memoirs and travei accounts. From that perspective, it is also observed how Lisbon is represented, in a similar process of activatingmemory,in picturesproduced by Vieira da Silva during his exile in Rio de Janeiro.</p>
A cidade e as serras: a odisséia bufa de um herói moderno
Authors: Oliveira Maria Edith M. de A. V. Rivelli de 
Published: July 2015

<p>Estudará a enunciação em primeira pessoa na escritura de Adélia Prado. Discutirá as relações entre o autor real e o autor do texto literário, realizando, além disso, a análise de alguns dos poemas representativos da anunciação desse discurso. Trabalhará o estatuto do confessional e do íntimo na veiculação da verdade poética, e a correlação desse eu com a produção do poético.</p><p>On étudiera l’emploi de l’ennonciation dans la première personne chez Adélia Prado. On discutera les rapports entre l’auter réel et l’auter du texte littéraire. On cherchera en plus à realiser l’analyse de quelques poèmes surtout les plus représentatifes de l’annonciation de ce type de discours. On travaillera de statut du confessionel et de l’intime dans la transmission de la verité poétique et la correlation de ce je dans la production du poétique.</p><p> </p>
A enunciação em primeira pessoa: o íntimo e o confessional em Adélia Prado
Authors: Fontenele Laéria Bezerra 
Published: July 2015

<p>Tendo em vista a importância, na atualidade, da categoria “espaço” como necessário conceito de análise, este artigo busca analisar a presença, na poesia de Adélia Prado, dessa categoria, o que se manifesta em tal poética numa constante tensão entre o particular e o universal, ou, para se utilizar uma terminologia mais atual, entre o local e o global. Nesse estudo, detive-me na análise de alguns poemas dos seguintes livros da poeta: <em>Bagagem </em>e <em>O coração disparado</em>.</p> <p>Dada la importancia, en la actualidad, de la categoría “espacio” como importante concepto de análisis, este artículo busca analizar la presencia, en la poesía de Adélia Prado, de esa categoría, lo que se manifiesta en esta poética en una constante tensión entre el particular y el universal, o, para utilizar una terminología mas actual, entre el local y el global. Los poemas que he extraído para hacer mis análisis están en los libros de la poetisa: <em>Bagagem </em>y <em>O coração disparado</em>.</p><p> </p>
Um poeta sebastianista e sua terra exígua
Authors: Oliveira Paulo Motta 
Published: July 2015

<p>Desde a independência do Brasil até o início do século XX Portugal não teve verdadeiramente colônias. Este artigo pretende analisar algumas das respostas formuladas por escritores para esta situação, e discutir o papel de Teixeira de Pascoaes nesse contexto.</p> <p>From the independence of Brazil to the beginning of the twentieth century Portugal had to live without a real colony. This essay intends to analyze some answers constructed by Portuguese writers to this situation, and discuss the importance of Teixeira de Pascoaes in this context.</p><p> </p>
Anacrônico, pois poeta: linguagem, memória e resistência na poesia de Paulo Henriques Britto
Authors: França Júlio 
Published: July 2015

<p>Estudo crítico da poesia de Paulo Henriques Brito, a partir da problematização do conceito de contemporâneo e anacrônico.</p> <p>Etude critique de la poésie de Paulo Henriques Brito, à partir, surtout, de la problematization des concepts tels que “contemporain” e “anacronique”.</p><p> </p>
Urbanidade, virtude e vício: o não-lugar da cidade na poesia pessoana
Authors: Ferreira Ermelinda 
Published: July 2015

<p>Neste trabalho pretendo mostrar como as diversas visões da cidade na poesia dos heterônimos pessoanos, influenciada pela poesia de seus mestres precursores, oscila entre a imagem virtuosa dos benefícios e a imagem viciosa dos malefícios do inevitável progresso, consolidandose, afinal, na idéia de um não-lugar, a cidade utópica e ideal, real porém onírica, cuja existência só é possível no espaço literário.</p> <p>This essay shows how the different visions of the city in the poetry of Fernando Pessoa’s heteronyms, influencied by the poetry of his precursors’ masters, goes from the virtuous image of the benefits to the vicious image of the malefactions of the inevitable progress, consolidating, finally, in the idea of a non-place, the utopian and ideal city, real but dreamlike, whose existence is possible only in the literary space.</p>
Do Salazarismo à Revolução dos Cravos: a História na literatura angolana
Authors: Ramos Marilúcia Mendes 
Published: July 2015

<p>Neste artigo, visamos refletir sobre as propostas do regime salazarista e sua aplicação e conseqüências em Angola, denunciadas em páginas literárias do escritor angolano Uanhenga Xitu, principalmente em Os <em>sobreviventes da máquina colonial depõem</em>... e <em>Os discursos do “Mestre” Tamoda, </em>romances metaficcionais, em que a história vai sendo entretecida à narrativa, trazendo à tona o problema da mão-de-obra, um dos pontoschave da política salazarista, agora revisto sob a ótica do angolano, que dá sua versão sobre o trabalho de contrato, enfatizando a atuação da igreja e de colonos.</p> <p>Dans cet article nous nous proposons de réfléchir sur les propositions du régime de Salazar, sur leur application à Angola et leurs conséquences, dénoncées dans des pages de l´écrivain angolais Uanhenga Xitu, surtout Os sobreviventes da máquina colonial depõem...et Os discursos do “Mestre” Tamoda, des romans métafictionnels, où l’histoire s’entremêle au récit, en faisant afflorer le problème de la main d’oeuvre, un des points-clés de la politique de Salazar, revu dans ces romans, sous l’optique de l’écrivain angolais, qui présente sa version sur le contrat de travail, en mettant en évidence l’action de l’église et des colons.</p>
Convergência, de Murilo Mendes: a materialidade do signo ou a “textualização do real”
Authors: Silva Evaldo Balbino 
Published: July 2015

<p>O presente artigo se propõe a fazer uma leitura do conto Uns braços de Machado de Assis, apontando nele alguns traços marcantes do estilo machadiano. Nesse sentido, pretendo estabelecer um diálogo entre aspectos do pensamento de Roland Barthes e a escrita de Machado. Destaco, no referido conto, sobretudo o traço do furo, da falta, da incompletude, do logro – marca persistente da narrativa machadiana – que desconforta o leitor, colocando-o em estado de crise, na sua relação com a linguagem. A meu ver, o texto do autor de Dom Casmurro, caracterizaria le texte de jouissance, nos termos propostos por Barthes. Nesse sentido tecerei considerações sobre a linguagem literária e o exercício de deslocamento produzido pelo escritor, no cerne da própria língua, promovendo, segundo Barthes uma trapaça salutar. Ainda me disponho a desenvolver, ao longo do estudo, reflexões acerca da importância da literatura, como força revolucinária que consiste em levantar questões sobre a própria realidade a qual não passa de construção discursiva e, portanto, é passível de ser modificada.</p> <p>Cet étude se propose à faire une lecture sur le texte Uns braços de Machado de Assis . On fera des considérations sur des traits rémarquables du style machadien qui se caractérize pour une narrative de la manque, de l’incomplétude. Une narrative qui provoque de l’angoisse au lecteur. Pourtant, un “texte de jouissance: celui qui met en état de perte, celui qui déconforte (peut-être jusqu’ à un certain ennui)”. On réflechira bien aussi sur le texte littéraire et l’exercice de déplacement introduit pour l’écrivain à l’intérieur même du langage, y faisant, selon la pensée de Barthes, un tourbillonemment salutaire; on réflechira, finalement sur des traits de la littérature comme une force révolutionnaire qui pose des questions sur la propre réalité qui n’est que des constructions de langage et, pourtant, elle peut être modifiée.</p>
Alphonsus de Guimaraens e os jornais: fragmentos de uma bibliografia lacunar
Authors: Ricieri Francine Fernandes Weiss 
Published: July 2015

<p>O texto estuda o romance <em>O casamento</em>, único escrito por Nelson Rodrigues para ser publicado diretamente em livro e não em capítulos diários de jornal. O enfoque é sobre a construção irônica do texto rodrigueano, responsável pela comicidade e humor presentes no livro.</p> <p>The text studies the novel <em>O casamento</em>, the only one written by Nelson Rodrigues to be published directly in book form and not serialized in daily chapters in a newspaper. The focus is on the ironic construction of Rodrigues’ texts, responsible for the comicality and humor present in the book.</p>