bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alkaloids from the Twigs and Leaves of Daphniphyllum macropodum
Authors: Zhang Chuan‐Rui , Liu Hong‐Bing , Dong Shi‐Hui , Wu Yan , Yue Jian‐Min 
Published: March 2013

AbstractThree new alkaloids, macrodumines A–C (1–3, resp.), along with ten known analogs, were isolated from the twigs and leaves of Daphniphyllum macropodum. Their structures were elucidated on the basis of spectroscopic methods. The 11‐OH configuration of the known alkaloid hydroxydaphgraciline (4) was assigned as α for the first time by comparing the NMR data with those of macrodumine C (3).
Synthesis of (4Z)‐4‐(Arylmethylidene)‐5‐ethoxy‐1,3‐oxazolidine‐2‐thiones by the Reaction of Ethyl (2Z)‐3‐Aryl‐2‐isothiocyanatoprop‐2‐enoates with Organolithium Compounds
Authors: Kobayashi Kazuhiro , Ezaki Kosuke , Hashimoto Hiroo 
Published: March 2013

AbstractA convenient one‐pot method for the preparation of (4Z)‐4‐(arylmethylidene)‐5‐ethoxy‐1,3‐oxazolidine‐2‐thiones 2 and 3 from ethyl (2Z)‐3‐aryl‐2‐isothiocyanatoprop‐2‐enoates 1, which can be easily prepared from ethyl 2‐azidoacetate and aromatic aldehydes, has been developed. Thus, these α‐isothiocyanato α,β‐unsaturated esters were treated with organolithium compounds, including lithium enolates of acetates, to provide 5‐substituted (4Z)‐4‐(arylmethylidene)‐5‐ethoxy‐1,3‐oxazolidine‐2‐thiones, 2, and 2‐[(4Z)‐(4‐arylmethylidene)‐5‐ethoxy‐2‐thioxo‐1,3‐oxazolidin‐5‐yl]acetates, 3.
Systematic review of prognostic factors predicting outcome in non‐surgically treated patients with sciatica
Authors: Verwoerd A.J.H. , Luijsterburg P.A.J. , Lin C.‐W.C. , Jacobs W.C.H. , Koes B.W. , Verhagen A.P. 
Published: March 2013

AbstractIdentification of prognostic factors for surgery in patients with sciatica is important to be able to predict surgery in an early stage. Identification of prognostic factors predicting persistent pain, disability and recovery are important for better understanding of the clinical course, to inform patient and physician and support decision making. Consequently, we aimed to systematically review prognostic factors predicting outcome in non‐surgically treated patients with sciatica. A search of Medline, Embase, Web of Science and Cinahl, up to March 2012 was performed for prospective cohort studies on prognostic factors for non‐surgically treated sciatica. Two reviewers independently selected studies for inclusion and assessed the risk of bias. Outcomes were pain, disability, recovery and surgery. A best evidence synthesis was carried out in order to assess and summarize the data. The initial search yielded 4392 articles of which 23 articles reporting on 14 original cohorts met the inclusion criteria. High clinical, methodological and statistical heterogeneity among studies was found. Reported evidence regarding prognostic factors predicting the outcome in sciatica is limited. The majority of factors that have been evaluated, e.g., age, body mass index, smoking and sensory disturbance, showed no association with outcome. The only positive association with strong evidence was found for leg pain intensity at baseline as prognostic factor for subsequent surgery.
Book Reviews
Authors: PROCITA LEONARD 
Published: March 2013

Book reviewed in this article:Marijuana—Deceptive Weed. Gabriel G. Nahas.Fetal Pharmacology. Lars O. BoreusAdvances in Cyclic Nucleotide Research, Volume 1: Physiology and Pharmacology of Cyclic AMP. P. Greengard, R. Paoletti, and G. A. RobisonAdvances in Cyclic Nucleotide Research, Volume 2: New Assay Methods for Cyclic Nucleotides. P. Greengard, R. Paoletti, and G. A. RobisonBasic and Clinical Pharmacology of Digitalis. Bernard H. Marks and Arnold M. WeisslerAnnual Review of Pharmacology, Volume 12. H. W. ElliotThe Benzodiazepines. S. Garattini, E. Mussini, and L. O. RandallHallucinogenic Drugs. F. Christine Brown. Charles C Thomas
Book Reviews
Authors: PROCITA LEONARD 
Published: March 2013

Book reviewed in this article:Methods of Analysis of Anti‐Epileptic Drugs. J. W. A. Meyer, H. Meinardi, C. Gardner‐Thorpe, and E. van der KleijnSymposium on Pharmacological Agents and Biogenic Amines in the Central Nervous System, Volume I. J. Knoll and K. MagyarClinical Immunobiology, Volume I. F. H. Bach and R. A. GoodDrug Receptors. H. P. RangReview of Neuromuscular Blocking and Stimulating Agents, Volumes 1 and 2. J. Cheymol
Book Reviews
Authors: PROCITA LEONARD 
Published: March 2013

Book reviewed in this article:Pharmacology of the Cerebral Circulation. Amilcare CarpiThe Management of Epilepsy. R. B. Aird and D. M. WoodburyThymic Hormones. T. D. LuckeyAdvances in Neurology, Volume 4: International Symposium on Pain. John J. BonicaTextbook of Pharmacology. G. Kuschinsky and H. LullmannMass Spectrometry in Biochemistry and Medicine. A. Frigerio and N. Castagnoli
Book Reviews
Authors: PROCITA LEONARD 
Published: March 2013

Book reviewed in this article:The Treatment of Parkinsonism with L‐Dopa. John MarksReview of Medical Microbiology, 11th Edition. E. Jawetz, J. L. Melnick, and E. A. AdelbergAdvances in Biochemical Psychopharmacology, Volume 7: Gas Chromatography‐Mass Spectrometry in Neurobiology. E. Costa, and B. HolmstedtAdvances in Neurology, Volume 5: Parkinson's Disease (Second Canadian‐American Conference). Fletcher McDowell and Andre BarbeauNeurochemistry of Cholinergic Receptors. E. de Robertis and J. SchachtDrugs and the Developing Brain (Advances in Behavioral Biology, Vol. 8). A. Vernadakis and N. Weiner
Book Reviews
Authors: PROCITA LEONARD 
Published: March 2013

Book reviewed in this article:Narcotic Antagonists (Advances in Biochemical Psychopharmacology, Volume 8). M. C. Braude, L. S. Harris, E. L. May, J. P. Smith, and J. E. VillarrealNeuropsychopharmacology of Monoamines and Their Regulatory Enzymes, (Advances in Biochemical Psychopharma‐cology, Volume 12). Earl UsdinCalcium Metabolism, Bone and Metabolic Bone Diseases. F. Kuhlencordt and H.‐P. KruseReview of Physiological Chemistry, Fifteenth Edition. H. A. HarperChemistry and Function of Colicins. Lowell P. HagerNeurosecretion—The Final Neuroendocrine Pathway. F. Knowles and L. VollrathBeta‐Adrenergic Blocking Agents in the Management of Hypertension and Angina Pectoris. Bruno MagnaniHandbook of Drugs and Chemical Stimulation of the Brain: Behavioral, Pharma‐cological and Physiological Aspects. R. D. MyersHandbook of Veterinary Drugs. A Compendium For Research and Clinical Use. I. S. Rossoff
Book Reviews
Authors: PROCITA LEONARD 
Published: March 2013

Book reviewed in this article:The Human Heart and Circulation. Visvan Navaratnam.Basic and Therapeutic Aspects of Perinatal Pharmacology. P. L. Morselli, S. Garattini, and F. SereniThe Clinical Uses of Levodopa. Gerald SternMechanisms of Action of Benzodiazepines (Advances in Biochemical Psychopharmacology, Vol. 14). E. Costa and P. GreengardPharmacy and the Law. Carl T. DeMarco.Progress in Chemical Toxicology, Volume 5. A. StolmanFundamentals of Clinical Pharmacokinetics. John G. Wagner. HamiltonAdvances in Cyclic Nucleotide Research, Volume 5. G. I. Drummond, P. Greengard, and G. A. Robison
The sulfur chain in biogas production from sulfate‐rich liquid substrates: a review on dynamic modeling with vinasse as model substrate
Authors: Barrera Ernesto L. , Spanjers Henri , Dewulf Jo , Romero Osvaldo , Rosa Elena 
Published: March 2013

AbstractVinasse is a sulfate‐rich liquid substrate, from which high levels of hydrogen sulfide in biogas can be obtained due to the sulfate reduction process under anaerobic conditions. Hydrogen sulfide is corrosive and toxic and must be removed for any utilization of the biogas. Mathematical models have been developed to study separately sulfate reduction in anaerobic digestion and sulfide removal from biogas streams. However, the levels of hydrogen sulfide produced in the anaerobic digestion stage have an effect on the sulfide removal processes in the next stage. As a method to study both processes and their interaction, a new approach is introduced and reviewed in the present article: the sulfur chain in biogas production. The necessity of studying the sulfate reduction processes in vinasse as a typical sulfate‐rich substrate to predict hydrogen sulfide concentrations in the gas phase, as well as the best model approach to that aim are established here. In addition, the approaches to model sulfide removal based on direct conversion processes, the models' capability to predict the removal of hydrogen sulfide from the biogas (at levels between 20 000 and 30 000 ppmv) as well as the concentration profile of the reactants in this removal processes are discussed. © 2013 Society of Chemical Industry
The Effect of Stress on Gill Basolateral Membrane Binding Kinetics of 5‐HT2 Receptor Ligands: Potential Implications for Urea Excretion Mechanisms
Authors: FRERE ALEXANDER W. , MCDONALD M. DANIELLE 
Published: March 2013

AbstractThe goal of this study was to determine the relationship between cortisol and the toadfish serotonin 2A (5‐HT2A) receptor, which is believed to be responsible for the activation of the toadfish urea transporter, tUT. We hypothesize that elevations in cortisol would play a role in the regulation of the 5‐HT2A receptor at the level of mRNA expression, ligand binding, and/or function. To test this idea, cortisol levels were manipulated by either crowding or through treatment with the cortisol synthesis blocker, metyrapone. Crowded fish had significantly higher circulating cortisol levels compared to uncrowded fish and cortisol levels in metyrapone‐treated fish were significantly lower than saline‐treated controls. No significant difference was measured in gill 5‐HT2A mRNA expression levels between uncrowded and crowded, control‐ or metyrapone‐treated fish. Furthermore, no significant difference was measured in [3H]‐5‐HT binding kinetics or in the competitive binding of the 5‐HT2 agonist, α‐methyl 5‐HT, to isolated gill basolateral membranes of uncrowded or crowded toadfish. However, the binding maximum (Bmax) of the 5‐HT2A receptor antagonist, [3H]‐ketanserin, was significantly different between all four groups of fish (metyrapone > control > crowded > uncrowded). Furthermore, metyrapone‐treated fish excreted approximately twofold more urea compared to controls when injected with α‐methyl 5‐HT, a 5‐HT2 receptor agonist shown to stimulate urea excretion. Our results suggest that cortisol may have differential effects on 5‐HT receptor binding, which could have potential implications on the control of pulsatile urea excretion in toadfish. J. Exp. Zool. 319A:237–248, 2013. © 2013 © 2013 Wiley Periodicals, Inc.
Disjoint 3‐Cycles in Tournaments: A Proof of The Bermond–Thomassen Conjecture for Tournaments
Authors: Bang‐Jensen Jørgen , Bessy Stéphane , Thomassé Stéphan 
Published: March 2013

AbstractWe prove that every tournament with minimum out‐degree at least contains k disjoint 3‐cycles. This provides additional support for the conjecture by Bermond and Thomassen that every digraph D of minimum out‐degree contains k vertex disjoint cycles. We also prove that for every , when k is large enough, every tournament with minimum out‐degree at least contains k disjoint cycles. The linear factor 1.5 is best possible as shown by the regular tournaments.
Correlations between first documented cardiac rhythms and preceding telemetry in patients with code blue events
Authors: Bhalala Utpal S. , Bonafide Christopher P. , Coletti Christian M. , Rathmanner Penny E. , Nadkarni Vinay M. , Berg Robert A. , Witzke Anita K. , Kasprzak Melody S. , Zubrow Marc T. 
Published: March 2013

BACKGROUNDAmong in‐hospital cardiac arrest (IHCA) patients, the first cardiac rhythm documented on resuscitation records (FDR) is often used as a surrogate for arrest etiology. Although the FDR generally represents the electrical activity at the time of cardiopulmonary resuscitation initiation, it may not be the ideal rhythm to infer the arrest etiology. We hypothesized that a rhythm present earlier—at the time of the code blue call—would frequently differ from the FDR, because the FDR might represent the later stage of a progressive cardiopulmonary process.OBJECTIVETo evaluate agreement between FDR and telemetry rhythm at the time of code blue call.DESIGNCross‐sectional study.SETTINGA 750‐bed adult tertiary care hospital and a 240‐bed adult inner city community hospital.PATIENTSAdult general ward patients monitored on the hospital's telemetry system during the 2 minutes prior to a code blue call for IHCA.INTERVENTIONNone.MEASUREMENTSAgreement between FDR and telemetry rhythm.RESULTSAmong 69 IHCAs, agreement between FDR and telemetry was 65% (kappa = 0.37). Among 17 events with FDRs of ventricular tachyarrhythmia (VTA), telemetry showed VTA in 12 (71%) and other organized rhythms in 5 (29%). Among 12 events with first documented rhythms of asystole, telemetry showed asystole in 3 (25%), VTA in 1 (8%), and other organized rhythms in 8 (67%).CONCLUSIONSThe FDR had only fair agreement with the telemetry rhythm at the time of code blue call. The telemetry rhythm may be a useful adjunct to the FDR when investigating arrest etiology. Journal of Hospital Medicine 2013;8:225–228. © 2013 Society of Hospital Medicine.
Pollen‐based palaeoclimate reconstructions over long glacial–interglacial timescales: methodological tests based on the Holocene and MIS 5d–c deposits at Sokli, northern Finland
Authors: SALONEN J. SAKARI , HELMENS KARIN F. , SEPPä HEIKKI , BIRKS H. JOHN B. 
Published: March 2013

AbstractPalaeoclimatic reconstructions over long glacial–interglacial timescales present major methodological challenges, as calibration methods based on modern climate and vegetation patterns may yield biased reconstructions from non‐analogue palaeoclimates, such as severely continental glacial periods. In this work, we present pollen‐based summer temperature reconstructions based on Holocene and early Weichselian (Marine Isotope Stages (MIS) 5d–c) deposits at Sokli, northern Finland. We attempt to improve the robustness of reconstructions of continental palaeoclimates by using two calibration sets, with one located in the region surrounding the fossil site and another in a more continental region in northwestern Russia. We assess the reliability of the reconstructions by estimating the compositional fit between fossil and calibration samples and by comparison with independent, plant macrofossil‐based reconstructions. We find the fossil samples to fit the extra‐regional, high‐continentality calibration set better during the early Holocene and MIS 5d–c. Especially in MIS 5d–c, however, even the high‐continentality calibration set fits the fossil samples poorly compared to the fit achieved in the mid and late Holocene. Thus our results highlight the problem of finding applicable calibration data for pre‐Holocene periods. We finally discuss the relative strengths and vulnerabilities of different calibration methods in reconstruction of non‐analogue palaeoclimates. Copyright © 2013 John Wiley & Sons, Ltd.
Transarterial embolization for acute head and neck bleeding: Eight‐year experience with emphasis on rebleeding risk in cancer patients
Authors: Bachar Gideon , Esmat Najjar , Stern Sagit , Litvin Sergey , Knizhnik Michael , Perlow Eliyahu , Atar Eli , Shpitzer Thomas , Belenky Alexander 
Published: March 2013

Objectives/HypothesisTo present our 8‐year experience with transarterial embolization for head and neck bleeding, with an emphasis on the need for repeated procedures in patients treated for head and neck cancer.Study DesignRetrospective case series.MethodsTertiary university‐affiliated medical center. The cohort included 49 patients who underwent transarterial embolization for acute head and neck bleeding in 2004 to 2012. Outcome measures included procedural success, recurrence, complications, and outcome.ResultsMean patient age was 60.3 years. Indications for transarterial embolization were bleeding from a tumor (42%), nasal bleeding (36%), bleeding related to neck trauma (8%), tracheal stomal bleeding (8%), and other (4%). Twelve of 21 patients with tumors had been treated by chemoradiation. At least one repeated procedure was required in 11 patients, of whom nine had a history of chemoradiation and surgery for cancer; four of them required a stent for exclusion of pseudoaneurysm, and in six the recurrence presented late after the initial procedure (1 month to 5 years). Major complications included cerebrovascular accident in one patient and death due to major bleeding in two cases. Twenty‐one patients died during follow‐up, including nine patients with cancer. Eleven deaths occurred up to 4 years after embolization.ConclusionsTransarterial embolization is an important tool for the control of head and neck bleeding. Special attention should be given to patients after chemoradiation for cancer. Every effort should be made to control the bleeding because some patients may gain a reasonable lifespan and improved quality of life.Level of Evidence4.
Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction
Authors: Berchtold Craig M. , Coughlin Adam , Kasper Zachary , Thibeault Susan L. 
Published: March 2013

Objectives/HypothesisNicotine, a major constituent of cigarette smoke, can activate the cholinergic anti‐inflammatory pathway by binding to α7‐nicotinic acetylcholine receptor (α7nAChR) expressed on the surface of certain cells. Here, we ask whether cigarette smoke extract induced different paracrine factors compared to the in vivo regulator of inflammation, tumor necrosis factor‐α, in human vocal fold fibroblasts (hVFFs) shown to express low levels of α7nAChR.Study DesignIn vitro.Methodsα7nAChR was detected by nested polymerase chain reaction and immunohistochemistry. γH2AX, a marker for DNA double‐stand breaks, was measured by immunofluorescence. Cigarette smoke extract was prepared in accordance with investigators studying effects of cigarette smoke. hVFFs treated for 3 hours had media replaced for an additional 24 hours. Cytokine, chemokine, and growth factor levels in media were assessed by multiplex analysis.Resultsα7nAChR expression levels decreased with the passage number of fibroblasts. Tumor necrosis factor‐α induced a significantly different profile of cytokines, chemokines, and growth factor compared to cigarette smoke extract exposure. Cigarette smoke extract at a concentration not associated with induction of γH2AX nuclear foci significantly increased vascular endothelial growth factor.ConclusionsCigarette smoke extract elicited a response important for regulation of angiogenesis and vascular permeability during inflammation, without evidence of DNA double‐stand breaks associated with carcinogenesis. hVFFs are capable of participating in paracrine regulation of pathological blood vessel formation associated with cigarette smoking–related diseases (ie, Reinke edema). These cells express α7nAChR, an essential component of the cholinergic anti‐inflammatory pathway regulated by the vagus nerve in certain tissues and a target of therapeutic agents. Laryngoscope, 123:2228–2236, 2013
Photoinduced Charge Separation of Self‐Organized Semiconducting Superstructures Composed of a Functional Polymer–TiO2 Hybrid
Authors: zur Borg Lisa , Domanski Anna L. , Berger Rüdiger , Zentel Rudolf 
Published: March 2013

AbstractThe incorporation of TiO2 nanoparticles into long (several micrometers) fibers of a gel‐forming poly(para‐phenylene vinylene) (PPV) derivative is described. For that purpose, a PPV‐block‐dopamine polymer is synthesized, which is used to coat TiO2 nanoparticles leading to well‐dispersed nanoparticles and fluorescence quenching of the polymer. Independently, the homopolymer gels in various organic solvents are observed to form long fibers. By mixing the PPV homopolymer with the TiO2‐PPV hybrid, we are able to incorporate the nanoparticles into the fibrous network, as shown in transmission electron microscopy (TEM) images. Photoinduced charge separation is measured by Kelvin probe force microscopy. Upon illuminating the polymer fibers, positive charges are observed, even at distances of around 300 nm. From these results, charge transport along the polymer fibers is inferred.magnified image
The Use of an Emulsion Templated Microcellular Poly(dicyclopentadiene‐co‐norbornene) Membrane as a Separator in Lithium‐Ion Batteries
Authors: Kovačič Sebastijan , Kren Harald , Krajnc Peter , Koller Stefan , Slugovc Christian 
Published: March 2013

AbstractThe preparation of open‐cell macroporous membranes made by the ring opening metathesis polymerization (ROMP) of a mixture of norbornene and dicyclopentadiene, and their basic applicability as separators in lithium‐ion batteries, is discussed. Cyclic voltammetry (CV) measurements of negative electrodes (graphite) and positive electrodes (LiCoO2) are performed and the results prove the absence of parasitic decomposition reactions within the membrane at high oxidative or reductive potentials. Furthermore, LiCoO2/Li half cell cycling studies of 100 charging/discharging cycles reveal that the newly disclosed separator and conventional commercial polyolefin based separators have similar performance. These results demonstrate that a potential weakness in the newly disclosed separator, namely residual double bonds present in the polymer network, does not limit the use of this material as a separator in lithium‐ion batteries.magnified image
Magnetic properties of N‐doped multi‐walled carbon nanotubes
Authors: Grechnev G.E. , Desnenko V.A. , Fedorchenko A.V. , Panfilov A.S. , Kolesnichenko Y.A. , Khrapatiy S.V. , Prylutskyy Y.I. , Matzui L.Y. , Ritter U. , Scharff P. 
Published: March 2013

AbstractThe magnetic properties of nitrogen‐doped multi‐walled carbon nanotubes (N‐MWCNTs) were studied in the temperature and magnetic field range of (4.2–290) K and (0.05–30) kOe, respectively. Also magnetic properties of the reference MWCNTs without nitrogen doping were investigated on the same footing for comparison. The presence of iron‐based particles inside N‐MWCNTs was detected. The low temperature SQUID (Superconducting Quantum Interference Device) magnetization measurements were supplemented with thermogravimetric analysis. The magnetic characterization provided the saturation magnetic moment MS and residual magnetization MR of N‐MWCNTs to be, respectively, 4.5 emu/g and 0.9 emu/g, whereas for the reference MWCNTs the corresponding parameters are found to be about twice higher. The coercive field value amounts to 800 Oe for both systems at low temperatures, then decreasing to about 450 Oe at 200 K.
Effect of multi‐walled iron‐filled carbon nanotubes on ATPase activity and superprecipitation of natural actomyosin
Authors: Andreichenko K. , Shelyuk O. , Prylutska S. , Nuryshchenko N. , Bogutska K. , Prylutskyy Y. , Ritter U. , Scharff P. 
Published: March 2013

AbstractThe dependence of actomyosin superprecipitation and Ca2+, Mg2+‐ and K+‐ATPase activity inhibition on the concentration of multi‐walled iron‐filled carbon nanotubes (Fe‐MWCNTs) was investigated. For the superprecipitation of actomyosin, a biphasic effect of Fe‐MWCNTs was found. Namely, at low concentrations (10–9 mg/ml) the superprecipitation was activated, while at high concentrations (10–7 and 10–5 mg/ml) its activity was inhibited.
Surface capturing of virion‐antibody complexes: Kinetic study
Authors: Boltovets P. M. , Boyko V. R. , Snopok B. A. 
Published: March 2013

AbstractThe presence of various components in complex biological samples which interact with inhomogeneous sensor surface, results in stretched exponential behaviour of the sensor response. This general concept was demonstrated by surface plasmon resonance (SPR) measurements of virus‐antibody complexes from crude plant homogenates on a gold surface, covered with protein A. The development of the viral infection in the plant Nicotiana tabacum was studied by SPR and ELISA (enzyme‐linked immunosorbent assay) as an indicative approach; a good agreement between both methods was shown. The correlation between virus concentration and the parameters of stretched exponential law was demonstrated. These results indicate that the parameters have hidden intrinsic properties of the underlying interfacial reactions and give a good basis for a more specific microscopic model.