bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use and outcome of radial versus femoral approach for primary PCI in patients with acute ST elevation myocardial infarction without cardiogenic shock: Results from the ALKK PCI registry
Authors: Bauer Timm , Hochadel Matthias , Brachmann Johannes , Schächinger Volker , Boekstegers Peter , Zrenner Bernhard , Zahn Ralf , Zeymer Uwe ,   for the Arbeitsgemeinschaft leitende kardiologische Krankenhausärzte (ALKK)
Published: May 2015

ObjectivesThis study sought to compare the use and outcome of radial versus femoral access in patients treated with primary percutaneous coronary intervention (PCI) for acute ST elevation myocardial infarction (STEMI) in clinical practice.BackgroundThe radial approach for PCI in patients with STEMI has been suggested to have a lower rate of complications and bleeding and to improve prognosis compared with the femoral approach. However, there still is a large regional and national variation in its use.MethodsBetween 2008 and 2012 a total of 17,865 patients with STEMI without cardiogenic shock undergoing primary PCI were prospectively enrolled in the observational German PCI registry of the Arbeitsgemeinschaft leitende kardiologische Krankenhausärzte (ALKK). Transfemoral (TF) access was used in 15,270 (85.5%), transradial (TR) access in 2,530 (14.2%), and other access in 65 (0.3%) patients. In this analysis, 10,264 patients from 20 centers that had performed at least 5 TR‐PCI for STEMI were included. This study compared TR‐PCI (n = 2,454 23.9%) with TF‐PCI (n = 7,810, 76.1%).ResultsProcedural success was high in both cohorts. Hospital mortality (1.8 vs. 5.1%, P < 0.001) and vascular access complications (0.3 vs. 1.8%, P < 0.001%) were lower in the TR group. In the multivariate analysis radial access was associated with an improved in‐hospital survival rate (OR 0.47, 95% CI 0.35–0.65).ConclusionsThe radial approach for PCI can be performed with excellent procedural success in selected STEMI patients and is associated with a lower rate of vascular access complications and hospital mortality. © 2015 Wiley Periodicals, Inc.
Postfunctionalization of BN‐Embedded Polycyclic Aromatic Compounds for Fine‐Tuning of Their Molecular Properties
Authors: Wang Xiao‐Ye , Yang Dong‐Chu , Zhuang Fang‐Dong , Liu Jia‐Jie , Wang Jie‐Yu , Pei Jian 
Published: May 2015

AbstractNew BN‐embedded, thiophene‐fused, polycyclic aromatic compounds with planar geometry were designed and synthesized. The molecules showed excellent stability and chemical robustness. Postfunctionalization on this skeleton was demonstrated with a series of electrophilic bromination, palladium‐catalyzed cross‐coupling, and Knoevenagel condensation reactions. The π skeleton remained intact during these late‐stage transformations. The optical and electronic properties have been well tuned through incorporation of electron‐rich and ‐deficient groups on the backbone. This work shows the great advantage of the postfunctionalization strategy on BN‐containing polycyclic aromatic compounds for fast diversification and materials screening.
ChemInform Abstract: Phase Relationships in the {Ho, Er}—Ni—Sn Ternary Systems at 673 K and Crystal Structure of New Ternary Compounds.
Authors: Romaka L. , Romaniv I. , Romaka V. V. , Pavlyuk V. 
Published: May 2015

AbstractThe 673 K isothermal sections of the phase diagram of the Ho‐Ni‐Sn and Er‐Ni‐Sn ternary systems are studied by two‐fold arc melting of the elements followed by annealing (Cu crucible, 673 K, 1 month).
ChemInform Abstract: Iron‐Catalyzed Reductive Magnesiation of Oxetanes to Generate (3‐Oxidopropyl)magnesium Reagents.
Authors: Sugiyama Yu‐ki , Heigozono Shiori , Okamoto Sentaro 
Published: May 2015

AbstractA facile method for the preparation of substituted 3‐oxidopropylmagnesium compounds from 2‐ and 2,3‐substituted oxetanes via a novel iron‐catalyzed reductive magnesiation reaction is presented.
ChemInform Abstract: Three‐Component Reaction Between Substituted β‐Nitrostyrenes, β‐Dicarbonyl Compounds and Amines: Diversity‐Oriented Synthesis of Novel β‐Enaminones.
Authors: Ye Weijian , Li Yan , Zhou Lanxiang , Liu Juanjuan , Wang Cunde 
Published: May 2015

AbstractTwo types of β‐enaminones [(IV) and (VI)] are efficiently synthesized through title reaction starting from cyclohexanediones (I) or chromenone (V), respectively.
ChemInform Abstract: N,N‐Dialkylaniline‐Assisted Thionation of Carboxylic Amides and Esters.
Authors: Yang Chun‐Hua , Li Guo‐Jing , Gong Chao‐Jun , Li Yue‐Ming 
Published: May 2015

AbstractCatalytic amounts of N,N‐diethylaniline are used to accelerate the thionation of amides and esters.
ChemInform Abstract: Green Process Development for the Synthesis of Aliphatic Symmetrical N,N′‐Disubstituted Thiourea Derivatives in Aqueous Medium.
Authors: Jangale Asha D. , Kumavat Priyanka P. , Wagh Yogesh B. , Tayade Yogesh A. , Mahulikar Pramod P. , Dalal Dipak S. 
Published: May 2015

AbstractThe title compounds such as (III) are highly efficiently obtained starting from primary aliphatic amines in aqueous media via a nonisothiocyanate route without the use of any catalyst and without any side product formation.
ChemInform Abstract: Hydration of Alkynes at Room Temperature Catalyzed by Gold(I) Isocyanide Compounds.
Authors: Xu Yun , Hu Xingbang , Shao Jing , Yang Guoqiang , Wu Youting , Zhang Zhibing 
Published: May 2015

AbstractTitle hydration process affords a variety of ketones [(II) or (IV), resp.] under mild reaction conditions in a simple one‐step procedure.
ChemInform Abstract: Scope and Mechanism in Palladium‐Catalyzed Isomerizations of Highly Substituted Allylic, Homoallylic, and Alkenyl Alcohols.
Authors: Larionov Evgeny , Lin Luqing , Guenee Laure , Mazet Clement 
Published: May 2015

AbstractThe intramolecular oxidation of unsaturated primary and secondary alcohols to aldehydes and ketones is achieved via Pd‐catalyzed olefin isomerization.
ChemInform Abstract: Radical‐Induced Metal and Solvent‐Free Cross‐Coupling Using TBAI—TBHP: Oxidative Amidation of Aldehydes and Alcohols with N‐Chloramines via C—H Activation.
Authors: Achar Tapas Kumar , Mal Prasenjit 
Published: May 2015

AbstractThe reaction can also be conducted under ball‐milling conditions at room temperature.
ChemInform Abstract: Synthesis of Isocyanides Through Dehydration of Formamides Using XtalFluor‐E.
Authors: Keita Massaba , Vandamme Mathilde , Mahe Olivier , Paquin Jean‐Francois 
Published: May 2015

AbstractIn somes cases the crude isocyanides show good purity allowing their direct use in multicomponent reactions such as the Passerini reaction [→ α‐acyloxyamides (V)].
ChemInform Abstract: Switching the Z/E Selectivity in the Palladium(II)‐Catalyzed Decarboxylative Heck Arylations of trans‐Cinnamaldehydes by Solvent.
Authors: Ban Shu‐Rong , Wang Hai‐Ning , Toader Violeta , Bohle D. Scott , Li Chao‐Jun 
Published: May 2015

AbstractThe Pd‐catalyzed Heck arylation of trans‐cinnamaldehyde furnishes preferentially the thermodynamically favored Z‐isomer in THF whereas, DMF provides the E‐isomer predominantly.
ChemInform Abstract: The Concise Synthesis of Unsymmetric Triarylacetonitriles via Pd‐Catalyzed Sequential Arylation: A New Synthetic Approach to Tri‐ and Tetraarylmethanes.
Authors: Nambo Masakazu , Yar Muhammad , Smith Joel D. , Crudden Cathleen M. 
Published: May 2015

AbstractA series of triarylacetonitriles (VII) is prepared by a sequence of Suzuki—Miyaura cross‐coupling of chloroacetonitrile (I) with boronic acids (II), a C—H arylation of arylacetonitriles (III) with aryl bromides (IV), and a final arylation of diarylacetonitriles (V) with aryl halides (VI).
ChemInform Abstract: Synthesis and Characterisation of an Open‐Cage Fullerene Encapsulating Hydrogenfluoride.
Authors: Krachmalnicoff Andrea , Bounds Richard , Mamone Salvatore , Levitt Malcolm H. , Carravetta Marina , Whitby Richard J. 
Published: May 2015

AbstractThe first encapsulation of hydrogen fluoride in an open‐cage fullerene is reported.
ChemInform Abstract: Diastereoselective Synthesis of Spirooxindole Derivatives via Biocatalytic Domino Reaction.
Authors: Liang Yi‐Ru , Chen Xiao‐Yang , Wu Qi , Lin Xian‐Fu 
Published: May 2015

AbstractA series of spirooxindole derivatives are synthesized using isatin derivatives, cyanoacetamide and 1,3‐dicarbonyl compounds as starting materials via one‐pot enzymatic or two‐step chemo‐enzymatic domino reactions.
ChemInform Abstract: Robust Synthesis of N‐Sulfonylazetidine Building Blocks via Ring Contraction of α‐Bromo N‐Sulfonylpyrrolidinones.
Authors: Kern Nicolas , Felten Anne‐Sophie , Weibel Jean‐Marc , Pale Patrick , Blanc Aurelien 
Published: May 2015

AbstractIn the presence of potassium carbonate various nucleophiles such as aliphatic alcohols, phenols, and anilines, but no thiols or benzylamine, are efficiently incorporated into N‐sulfonylpyrrolidinones to form azetidine derivatives.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Annulation of Enals to Aurone Analogues: Synthesis of Cyclopentene‐Fused Spirobenzofuran‐3‐ones.
Authors: Seetha Lakshmi K. C. , Krishnan Jagadeesh , Sinu C. R. , Varughese Sunil , Nair Vijay 
Published: May 2015

AbstractAryl, hetaryl, alkyl and alkenyl enals are reacting with 2‐aroylidene substituted alkylbenzofuran‐3‐ones providing the corresponding products as single diastereomers.
ChemInform Abstract: Ruthenium‐Catalyzed Direct C3 Alkylation of Indoles with α,β‐Unsaturated Ketones.
Authors: Li Shuai‐Shuai , Lin Hui , Zhang Xiao‐Mei , Dong Lin 
Published: May 2015

AbstractThe novel C—H activation methodology exhibits a broad substrate scope with respect to the indole/pyrrole and ketone educts.
ChemInform Abstract: Pseudopericyclic 1,5‐ versus Pericyclic 1,4‐ and 1,6‐Electrocyclization in Electron‐Poor 4‐Aryl‐2‐azabuta‐1,3‐dienes: Indole Synthesis from 2H‐Azirines and Diazo Compounds.
Authors: Novikov Mikhail S. , Khlebnikov Alexander F. , Rostovskii Nikolai V. , Tcyrulnikov Sergei , Suhanova Anna A. , Zavyalov Kirill V. , Yufit Dmitry S. 
Published: May 2015

AbstractThe Rh(II)‐catalyzed coupling reactions of azirines with diazocarbonyl compounds is found to depend on the nature of the azirine and diazocarbonyl substituents.
ChemInform Abstract: Oxidative Nucleophilic Cyclization of 2‐Alkynylanilines with Thiophenols under Metal‐Free Conditions.
Authors: Han Dandan , Li Zhiming , Fan Renhua 
Published: May 2015

AbstractDFT‐calculations support a reaction pathway consisting of a PhI(OAc)2‐mediated oxidative dearomatization and a Broensted‐acid promoted nucleophilic cyclization.
ChemInform Abstract: Efficient Synthesis of Indoles from 2‐Alkynylaniline Derivatives in Water Using a Recyclable Copper Catalyst System.
Authors: Song Senchuan , Huang Manna , Li Wenjun , Zhu Xinhai , Wan Yiqian 
Published: May 2015

AbstractA recyclable catalyst system consisting of CuI, Bu4NBr, and polystyrene‐supported perruthenate effectively promotes the cyclization reaction of ethynyl‐N‐sulfonylanilides to indoles in water.
ChemInform Abstract: Copper‐Catalyzed Tandem Reactions for Synthesis of Pyrazolo[5,1‐a]isoquinolines with Heterocyclic Ketene Aminals as Ligands.
Authors: Wen Li‐Rong , Jin Xian‐Jun , Niu Xiao‐Dong , Li Ming 
Published: May 2015

AbstractCuI in combination with an imidazoline diketone ligand (KAM) allows the coupling of substrates (I) and (X) with acetonitrile derivatives to give functionalized pyrazoloisoquinolines.
ChemInform Abstract: Construction of 2‐Pyrone Skeleton via Domino Sequence Between 2‐Acyl‐1‐chlorocyclopropanecarboxylate and Amines.
Authors: Zhu Yuequan , Gong Yuefa 
Published: May 2015

AbstractThe title reaction proceeds smoothly in the presence of inorganic bases, providing a straightforward and transition metal‐free method to construct the pyrone skeleton.
ChemInform Abstract: Rapid Synthesis of Isoquinolinones by Intramolecular Coupling of Amides and Ketones.
Authors: Wei Wen‐Tao , Liu Yu , Ye Lin‐Miao , Lei Rong‐Hui , Zhang Xue‐Jing , Yan Ming 
Published: May 2015

AbstractAmides and ketones are intramolecularly coupled in the presence of KOtBu in DMF.
ChemInform Abstract: Synthesis of 2‐(Trifluoromethyl)benzo[b][1,8]naphthyridin‐4(1H)‐one Derivatives Using Trifluoroacetimidoyl Chlorides.
Authors: Romero Angel H. , Salazar Jose , Lopez Simon E. 
Published: May 2015

Abstract11 Title compounds are prepared from 2‐chloro‐3‐acetyl‐quinolines (I), which can easily prepared in two steps from readily available 2‐chloro‐3‐formylquinolines.
ChemInform Abstract: Synthesis of Seven‐Membered Fused Sultones by Reductive Heck Cyclization: An Investigation for Stereochemistry Through DFT Study.
Authors: Mondal Shovan , Debnath Sudarshan , Das Babulal 
Published: May 2015

AbstractAn efficient route is achieved for the synthesis of sultones based on chemoselective Sonogashira coupling followed by Pd(0)‐catalyzed intramolecular Heck type cyclization.
ChemInform Abstract: Rh(III)‐Catalyzed Selenylation of Arenes with Selenenyl Chlorides/Diselenides via C—H Activation.
Authors: Yu Songjie , Wan Boshun , Li Xingwei 
Published: May 2015

AbstractTwo alternative, simple procedures for the Rh(III)‐catalyzed selenylation of arenes bearing a directing group (29 examples) are developed.
ChemInform Abstract: The Nitrogenous Hamigerans: Unusual Amino Acid‐Derivatized Aromatic Diterpenoid Metabolites from the New Zealand Marine Sponge Hamigera tarangaensis.
Authors: Dattelbaum Jonathan D. , Singh A. Jonathan , Field Jessica J. , Miller John H. , Northcote Peter T. 
Published: May 2015

AbstractNine new nitrogenous hamigeran diterpenoids are isolated and screened for their activity against the HL‐60 cell lines.
ChemInform Abstract: 1,4 Addition of Unprotected Pyrrole onto Chiral Acrylamides: Toward Synthesis of New Polypeptidic Architectures.
Authors: Gratais Alexander , Pannecoucke Xavier , Bouzbouz Samir 
Published: May 2015

AbstractA diversity of new functionalized acyclic chiral pyrrolamide compounds is synthesized by a robust process involving the creation of a C—C bond between pyrrole (I) and acyclic chiral acrylamides in the presence of Lewis acids.
ChemInform Abstract: A New Indole Alkaloid from Voacanga grandifolia.
Authors: Morita Hiroshi , Haseo Azusa , Eko Nugroho Alfarius , Hirasawa Yusuke , Kaneda Toshio , Shirota Osamu , Rahman Abdul , Kusumawati Idha , Cholies Zaini Noor 
Published: May 2015

Abstractisolation and structure elucidation of the new vobasine‐iboga type bisindole alkaloid, voacalgine F (I)
Randomized trial to increase colorectal cancer screening in an ethnically diverse sample of first‐degree relatives
Authors: Bastani Roshan , Glenn Beth A. , Maxwell Annette E. , Ganz Patricia A. , Mojica Cynthia M. , Alber Susan , Crespi Catherine M. , Chang L. Cindy 
Published: May 2015

BACKGROUNDEthnic minorities, especially African Americans and Latinos, bear a disproportionate burden of colorectal cancer (CRC), as reflected in incidence, cancer stage, and mortality statistics. In all ethnic groups, first‐degree relatives (FDRs) of CRC cases are at an elevated disease risk. However, underuse of CRC screening persists and is particularly evident among minority groups. The current study tested a stepped intervention to increase CRC screening among an ethnically diverse sample of FDRs of CRC cases.METHODSA statewide cancer registry was used to recruit CRC cases and through them their FDRs. Relatives who were not current on CRC screening were randomized to intervention or usual‐care control arms. The stepped intervention consisted of ethnically targeted and individually tailored print materials followed by telephone counseling for those unscreened at 6 months.RESULTSThe study sample of 1280 individuals consisted of 403 Latino, 284 African American, 242 Asian, and 351 white FDRs. Statistically significant effects were observed for the cumulative print plus telephone intervention at 12 months (26% in the intervention vs 18% in the control group) and the print intervention alone at 6 months (15% in the intervention vs 10% in the control group). The effect of the print intervention alone versus the cumulative interventions was not statistically significantly different. Stratified analyses indicated that the intervention was effective among white, Latino, and Asian individuals, but not among African‐Americans.CONCLUSIONSOverall, the intervention was effective in increasing screening rates. Oversampling racial/ethnic minorities allowed for the examination of effects within subgroups, revealing no effect among African American individuals. This finding illustrates the importance of including sufficient numbers of participants from diverse ethnic subgroups in intervention research to enable such stratified analyses. Cancer 2015;121:2951–2959. © 2015 American Cancer Society.
A Classification of Isolated Singularities of Elliptic Monge‐Ampére Equations in Dimension Two
Authors: Gálvez José A. , Jiménez Asun , Mira Pablo 
Published: May 2015

AbstractLet ℳ1 denote the space of solutions z(x,y) to an elliptic, real analytic Monge‐Ampére equation whose graphs have a non‐removable isolated singularity at the origin. We prove that ℳ1 is in one‐to‐one correspondence with ℳ2 × ℤ2, where ℳ2 is a suitable subset of the class of regular, real analytic, strictly convex Jordan curves in ℝ2. We also describe the asymptotic behavior of solutions of the Monge‐Ampére equation in the Ck‐smooth case, and a general existence theorem for isolated singularities of analytic solutions of the more general equation .© 2015 Wiley Periodicals, Inc.
Identification of new oral dosing regimens for the neuraminidase inhibitor oseltamivir in patients with moderate and severe renal impairment
Authors: Kamal Mohamed A. , Brennan Barbara J. , Subramoney Vishak , Lien Yi Ting (Kayla) , Morcos Peter N. , Frey Nicolas , Rayner Craig R. 
Published: May 2015

AbstractAvailability of lower‐dose oseltamivir capsules, an increased pharmacokinetic database, and a desire to align drug exposure across the spectrum of renal function prompted reassessment of oral dosing in patients with renal impairment. The data set comprised 128 subjects (71 with varying degrees of renal impairment) from 8 studies, which included single and multiple doses of 20–1000 mg. Pharmacokinetic profiles of oseltamivir phosphate (OP) and oseltamivir carboxylate (OC) were modeled simultaneously in NONMEM. Exposure metrics of OP and OC (AUC48 h, Cmax, Cmin) after administration of various dosing regimens were simulated for renal impairment subgroups and compared with exposures in patients with normal renal function receiving approved regimens. For influenza treatment, 30 mg once‐daily and twice‐daily regimens were selected for severe and moderate impairment, respectively. These regimens provided OC exposures similar or above those of the approved 75‐mg twice‐daily treatment regimen in subjects with normal renal function. For influenza prophylaxis, 30 mg once every other day and once‐daily regimens were selected for severe and moderate impairment, respectively. No dosing adjustments were required for mild impairment. This analysis supported revised labeling in the United States and Europe for oral oseltamivir dosing in patients with moderate and severe renal impairment.
Fluorinated Alcohols as Activators for the Solvent‐Free Chemical Fixation of Carbon Dioxide into Epoxides
Authors: Gennen Sandro , Alves Margot , Méreau Raphaël , Tassaing Thierry , Gilbert Bernard , Detrembleur Christophe , Jerome Christine , Grignard Bruno 
Published: May 2015

AbstractThe addition of fluorinated alcohols to onium salts provides highly efficient organocatalysts for the chemical fixation of CO2 into epoxides under mild experimental conditions. The combination of online kinetic studies, NMR titrations and DFT calculations allows understanding this synergistic effect that provides an active organocatalyst for CO2/epoxides coupling.
Quartz Crystal Microbalance Sensor for NH3 Gas with Compensation of Humidity Drift
Authors: USHIMI YOSHIMITSU , ITO YOSHIHIRO , HORIUCHI HIDEYA , KADOTA MICHIO , NOZAKI YOSHIMI , HOTTA YOSHIO , SHIRATORI SEIMEI 
Published: May 2015

SUMMARYA quartz crystal microbalance (QCM) sensor coated with a sensing film has been studied as a gas‐sensing device with high gas selectivity and high sensor sensitivity. One of the problems to be solved for practical applications is that the resonant frequency of a QCM sensor drifts due to the influence of humidity. We investigated a method for compensating the humidity drift of a QCM sensor for NH3 gas by using an element coated with a reference film that was prepared by modifying the phosphate group of zirconium phosphate in the sensing film with sodium hydroxide. The response characteristics of the reference element were measured. The results showed good agreement with the humidity response of the sensor element when not responding to ammonia gas. It was found that compensation of the humidity drift was successfully accomplished by calculating the frequency difference between the sensor element and the reference element. An application to small QCM (1.3 × 0.9 mm) is also presented.
Interface State Density Evaluation of p‐Type and n‐Type Ge/GeNx Structures by Conductance Technique
Authors: IWASAKI TAKURO , ONO TOSHIRO , OTANI YOHEI , FUKUDA YUKIO , OKAMOTO HIROSHI 
Published: May 2015

SUMMARYGe‐MIS structures have attracted attention as next‐generation CMOS devices. We have reported that a GeNx/Ge structure with a low interface state density can be made by the electron cyclotron resonance (ECR) plasma technique, and that the interface state density of Ge‐MIS structures can be evaluated through characteristic analysis in the inversion region even at room temperature. In this report, we evaluate the interface state density of p‐type and n‐type GeNx/Ge structures using the conductance technique at low temperature and characteristic analysis at room temperature, and the related process dependences. We have successfully evaluated the interface characteristics of GeNx/Ge structures. The interface state density was systematically distributed with respect to the midgap, and the density near the midgap was close to that of the GeO2/Ge structure.
Classification and Size Estimation of Wafer Defects by Using Scattered Light Distribution
Authors: SUGIHARA YOSHIHIKO , HONDA TOSHIFUMI , URANO YUTA , WATANABE MASAHIRO , NOGUCHI SO , IGARASHI HAJIME 
Published: May 2015

SUMMARYUsually, wafer inspection is a two‐step process. The first step, which is very important, consists of detection of defects on the wafer. The second step classification of the detected defects, which is done after defect detection as necessary. Recently, it has become necessary to perform simultaneous detection and classification of wafer defects in order to reduce the wafer inspection time while maintaining high resolution of inspection. Optical wafer inspection is the most effective method for detecting and classifying defects and estimating their size in a short time. In this method, the scattered light distribution is compared with a database of previous scattered light distributions and pattern matching is used to classify defects and estimate their size. Therefore, to achieve optical wafer inspection based on scattered light distribution, it is necessary to gather scattered light distribution data for many samples of various kinds. The first aim of this study is to develop a defect classification and size estimation method utilizing the scattered light distribution. We propose a method of classifying defects on wafers and estimating their size. The proposed method is based on pattern matching utilizing a parametric eigenspace. The second aim of the paper is to validate the proposed method by applying it to scattered light distribution samples. The light scattering distribution samples were generated by discrete dipole approximation (DDA) simulation. A database of the light scattering distribution is easily created using the simulation.