bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 24: Granulocytes to Induce Donor-Derived T Cell Expansion after T Replete, Mismatched CB in Post-Transplant Relapsed and Refractory Paediatric Acute Leukaemia: Results of Grans Trial
Authors: Senthil Srividhya , Moothedath Abdul , Rauthan Archana , Peppas Ioannis , Potluri Sandeep , Calvert Richard , Evans Pamela , Broderick Valerie , Lawson Sarah , Furness Caroline , Roberts Wing , Patrick katharine , Rao Kanchan , Wynn Robert 
Published: August 2024

Abstract

Introduction
Refractory and post-transplant relapsed Acute Leukaemia remain difficult to cure. Third-party pooled granulocytes induce massive, transient, donor-derived T-cell expansion after Cord Blood (CB) transplant. These expanded T-cells are cytotoxic, memory CD8, in contrast to the infused graft T-cells which are predominantly naïve CD4, and appear a priori candidate anti-tumour T-cells.

Objectives
In our prospective clinical trial, GRANS study (NCT05425043), we have given granulocytes peri-transplant with T-replete, deliberately mismatched CB to enhance the graft-versus-leukaemia effect of the transplant, in those with either primary refractory or relapsed/ refractory paediatric acute leukaemia. Here we report outcomes of all patients treated with this approach, including trial and off-trial patients.

Methods
Case records were analysed and data collected about patients’ demographics, transplant and donor characteristics and the outcomes including engraftment, acute and chronic GVHD, relapse and transplant related mortality. All patients (n=25) were given 7 daily doses of granulocytes starting from D-1. Immune suppression was withdrawn early.

Results
The granulocytes are well tolerated, no grade 3 or 4 CRS was encountered. There is increased graft rejection (seen in 4 patients) compared to a cohort of T-replete cord blood transplants in children with haematologic malignancy. In those that reject, then there is always residual leukaemia present. 2 of these patients successfully engrafted after a second CBT. Low severe aGVHD. Only 12% (n=3) developed severe aGVHD, despite early withdrawal of immunosuppression. No cGVHD was seen. Treatment related mortality is low, and 2 patients died, one with severe VOD and one with disseminated, aciclovir-resistant HSV infection. In those that do not reject the graft, all but one patient became MRD negative. In some, there is later relapse (n=7).The OS and the EFS were 56% (n=14) and 48% (n=12) respectively.

Discussion
The rates of aGVHD are tolerable, there is no cGVHD and the TRM is remarkably low, despite the mismatched graft. There is a higher graft failure rate and in those that do not experience GF, the remission rates are high but some patients relapse. In our next protocol, we plan to use an expanded CB to reduce GF, and cord derived DLI after cessation of immune suppression to reduce late relapse.
Abstract 25: During CB Transplant in MRD-Positive AML, Relapse is Usually Early, is Reduced by Acute GVHD and is Influenced by Ciclosporin Exposure: A Multicenter National Experience
Authors: Moothedath Abdul , Rauthan Archana , Peppas Ioannis , Potluri Sandeep , Calvert Richard , Evans Pamela , Broderick Valerie , Lawson Sarah , Furness Caroline , Roberts Wing , Patrick Katharine , Rao Kanchan , Wynn Robert , Senthil Srividhya 
Published: August 2024

Abstract

Introduction
We report a multicentric experience of the relationship between ciclosporin exposure and time to relapse in a large homogenous cohort of paediatric AML patients receiving a T-replete cord blood transplant(TRCBT), adjusted to pre-transplant MRD and GVHD.

Objectives
The primary endpoint was time to relapse, and its relationship between ciclosporin AUC, use of additional immunosuppressive treatment (IST) and its total duration was investigated by multivariate Cox regression analysis.

Methods
It is a retrospective study, analyzing data from 7 paediatric transplant centers in the UK on children who had a TRCBT for HR AML between 2013 and 2023. Case records were analyzed to get transplant characteristics, GVHD prophylaxis, trough ciclosporin levels in the first 8 weeks and the transplant outcomes including GVHD and IST used, relapse and transplant related mortality (TRM).

Results
The cohort included 124 patients, 66 were MRD-positive pre-transplant, with a median follow up of 737.1 days (range:24-3540 days). The mortality rate was 40.7% and three-quarters occurred in the MRD-positive group. The median time to relapse was 180 days (range: 32 to 949). TRM was 13% and was the most prominent cause of mortality in MRD-negative group.The RFS is greater in MRD-negative group without severe aGVHD than in those with severe aGVHD, though not statistically significant. The RFS is significantly lower in the MRD-positive group without severe aGVHD than in those with it. The COX proportional hazards model using 95% CI confirmed a significant inverse relationship of AUC of Ciclosporin in the first 8 weeks on the time to relapse (p&lt;0.02) and such a significant relationship maintained even after adjusting for the MRD status (p&lt;0.03) and the presence of severe aGVHD (p&lt;0.016). There was a significant inverse relationship between duration of CNI and time to relapse (p&lt;0.03). The study did not find any effect of IST or its duration on time to relapse (p=0.567 and p=0.241 respectively).

Discussion
This is the largest homogenous cohort of TRCBT in AML investigating the role of ciclosporin prophylaxis on relapse. It confirms the importance of GVL effect and its relation to GVHD, particularly in MRD-positive patients as RFS is significantly better in those who experience aGVHD.
Switching costs and users’ intentions of an app-enabled cross-border e-commerce platform: examples of Amazon and Tmall Global
Authors: Li Jun , He Ye 
Published: August 2024

PurposeUsing surveys of Amazon and Tmall Global users, this paper aims to empirically investigate the issue of platform technological selection. We explore the impact of switching costs on users’ intentions to use an app-enabled cross-border e-commerce (CBEC) platform based on an extended technology acceptance model (TAM). The results suggest that the higher the switching cost of a platform is, the greater the users’ satisfaction and intention to use this platform. Therefore, for the platform, a moderate switching cost will be beneficial for retaining users.Design/methodology/approachBased on the TAM, this paper takes the switching costs as the starting point and focuses on exploring the relationships among switching costs, perceived usefulness, perceived ease of use, perceived reliability, satisfaction and intention to use. Online surveys of users of Amazon and Tmall Global are adopted as the main instruments of this research. We collected a total of 408 valid responses from Amazon users and 490 from Tmall Global users. For the data analysis, this study conducts frequency analysis, a test analysis of the reliability and validity of the measures, correlation analysis, and path analysis using a structural equation model.FindingsThe results show that switching costs positively affect the users’ satisfaction and intentions to use a CBEC platform through perceived usefulness, perceived ease of use and perceived reliability.Research limitations/implicationsThe questionnaire respondents were predominantly Chinese due to the constraints of the survey conditions. In fact, China has a high penetration rate in CBEC, and Chinese users have rich experience using the Amazon and Tmall Global platforms.Practical implicationsThe development of CBEC has ups and downs, and users frequently switch platforms. Considering how platforms can stand out from the crowd and retain users, we believe that a moderate increase in the switching cost of the platform is helpful for companies to address these problems, and the implications of the results are particularly valid for decision-makers of CBEC platforms and companies.Social implicationsAmazon and Tmall Global are the two largest CBEC platforms in the world. Using these two companies as examples for comparison can effectively identify the differences between the platforms and the conclusions are representative. We suggest that platforms can improve user satisfaction and willingness to use by establishing VIP communities, issuing coupons, providing shipping services as well as convenient after-sale complaint channels, and improving the platform’s easy-to-use interface, as ways to further enable the platform to retain more users and stand out in fierce competition.Originality/valueThis paper addresses an interesting and practical issue related to the effects of introducing switching costs in an extended TAM applied to CBEC platforms.
The effects of inclusive psychological climate, leader inclusion, and workgroup inclusion on trust and organizational identification
Authors: Chung Beth G. , Shore Lynn M. , Wiegand Justin P. , Xu Jia 
Published: August 2024

PurposeThis study examines the effects of an inclusive psychological climate on leader inclusion, workgroup inclusion, and employee outcomes (trust in organization and organizational identification). Leader inclusion and workgroup inclusion are explored as both direct and serial mediators in the psychological climate to outcome relationships.Design/methodology/approachData from 336 employees in 55 teams were collected at two time points from an educational media company in China.FindingsResults from multi-level modeling suggest that, for employees, the inclusive psychological climate to trust relationship has both direct and indirect effects, including a serially occurring indirect effect through leader inclusion and workgroup inclusion. For the inclusive psychological climate to organizational identification relationship, there were only indirect effects, including a serially occurring indirect effect through both leader inclusion and workgroup inclusion.Research limitations/implicationsThese results suggest the value of an inclusive psychological climate for setting the stage for more localized inclusion experiences through the leader and the workgroup. These inclusionary work environments promote social exchange as shown by employer trust and social identification with the organization.Originality/valueThis study examines the combined and serial effects of an inclusive psychological climate, leader inclusion, and workgroup inclusion on outcomes that represent a deep connection with the organization (organizational trust and organizational identification).
“Banged up with ADHD”: a qualitative analysis of the experiences of adult men with ADHD in prison
Authors: Roberts Kayleigh , Lawrence Daniel 
Published: August 2024

Purpose
A recent Ministry of Justice inquiry highlighted the need for more awareness of neurodivergent conditions in the Criminal Justice System. Although evidence suggests a prevalence rate of 25% for attention deficit hyperactivity disorder (ADHD) within the UK prison population, there is no research to date that has explored the experiences of people with ADHD in prison. Therefore, this study aims to address this gap in the literature.

Design/methodology/approach
Data was collected within an adult male Category B prison. Semi-structured interviews were carried out with eight prisoners who had a formal diagnosis of ADHD. Reflexive thematic analysis was used to look for patterns across the data that addressed the research question.

Findings
Five themes were generated from the analysed data that included “The unsuitability of the prison environment”; “The impact of the prison regime”; “A lack of resources”; “The importance of staff and prisoner relationships”; and “Response to medication”.

Research limitations/implications
The findings of this study may be difficult to generalise given the specific characteristics of the participants. The participants were all adult males with a formal diagnosis of ADHD, taking prescribed medication, recruited from one prison and all resided on one wing that had been adapted to support neurodivergent people. Although qualitative research is not intended to be generalisable in the broad sense, the findings of this study may be transferable to individuals in other settings who share similar characteristics with the current study where parallels can be drawn.

Practical implications
Participants described the prison environment as being unresponsive to their neurodiverse needs. Findings support the need for awareness training for staff along with a compassionate approach to working relationships and psycho-educational work for prisoners for all to have a better understanding of the needs of this group of people.

Originality/value
To the best of the authors’ knowledge, there are currently no qualitative studies that have sought to learn from individuals living with ADHD in prison themselves.
It’s the moment of truth: a longitudinal study of touchpoint influence on business-to-business relationships
Authors: Cambra-Fierro Jesús , Patrício Lia , Polo-Redondo Yolanda , Trifu Andreea 
Published: August 2024

PurposeCustomer–provider relationships unfold through multiple touchpoints across different channels. However, some touchpoints are more important than others. Such important touchpoints are viewed as “moments of truth” (MOTs). This study examines the impact of a series of touchpoints on an MOT, and the role MOTs play in determining future profitability and other behavioral outcomes (e.g. customer retention and customer cross-buy) in a business-to-business (B2B) context.Design/methodology/approachBuilding upon social exchange theory, a conceptual model is proposed and tested that examines the impact of human, digital, and physical touchpoints and past MOTs on customer evaluation of a current MOT and on future customer outcomes. This research employs a longitudinal methodology based on a unique panel dataset of 2,970 B2B customers.FindingsStudy results show that all touchpoints significantly contribute to MOTs, while human and physical touchpoints maintain their primacy during MOTs. The impact of MOTs on future customer outcomes is also demonstrated.Practical implicationsThis study highlights the need for prioritizing human and physical touchpoints in managing MOTs, and for carefully managing MOTs across time.Originality/valueGiven its B2B outlook and longitudinal approach, this research contributes to the multichannel and interactive marketing literature by determining relevant touchpoints for B2B customers.
“One of Us”/“One of them”: negotiating peer support on a men’s mental health ward
Authors: Gray Benjamin Thomas , Sisto Matthew , Conley Renee 
Published: August 2024

Purpose
The purpose of this service user narrative and viewpoint article is to describe interprofessional and interpersonal barriers to peer support on a men’s mental health ward over the course of a year from a lived experience perspective.

Design/methodology/approach
A reflective journal was kept and participant observation was conducted over the course of the year.

Findings
There is sometimes a fissure and binary of “Us” and “Them” on the ward. In other words, staff can sometimes perceive peer support workers to be “one of us” (a member of staff) or “one of them” (a service user). For service users, the opposite is sometimes true: “one of us” (a service user) or “one of them” (a member of staff). Peer support workers must bridge this gap and strive to be “one of us” with both these groups, which is no easy task. A good ward manager or peer team leader can smooth over interprofessional differences and support the peer worker in their efforts of care towards the recovery of people with mental health problems.

Originality/value
Little has been written on this topic in a mental health inpatient setting as most papers address community peer support work, which is very different from peer support in hospital. This paper addresses one of the first peer support pilot projects in hospital of its kind in NHS England so is quite innovative and perhaps even unique.
The role of digital finance, technological innovation, and human development to utilize natural resources efficiently: Analysis from developing Asia
Authors: Hehua Luo , Iqbal Zahid , Abidin Syed Zain Ul , Alharthi Aiedh Mrisi , Albalawi Olayan , Tian Tian 
Published: August 2024

AbstractThis study explores the transformative impact of the convergence of digital finance, technological innovation, and human development on the utilization of natural resources. Employing panel data from 1995 to 2019 for developing Asian nations and utilizing the CS Autoregressive Distributed Lag (CS‐ARDL) model, the research unveils a positive and significant relationship between all independent variables and the utilization of natural resources. The collaborative interplay among these variables has led to remarkable progress, profoundly influencing the sustainable management of the Earth's finite resources. Positioned at the forefront of the digital revolution, financial technologies (fintech) have emerged as potent instruments, facilitating access to financial services and fostering comprehensive economic growth. Within developing Asian nations, the intricate dynamics among digital finance, technological innovation, and human development hold substantial potential to optimize natural resource efficiency, promoting sustainable economic growth and environmental stewardship. The amalgamation of these factors plays a pivotal role in nurturing sustainable practices, mitigating environmental degradation and propelling fair socioeconomic development.
Alveolar osteonecrosis and tooth exfoliation following herpes zoster infection: A case report and review of the literature
Authors: Sun Z , Chen E , Yi D , Xiao S 
Published: August 2024

ABSTRACTTooth loss and osteonecrosis of the jaw are a serious and rare oral complications of herpes zoster infection, particularly in immunocompetent individuals. An immunocompetent 58‐year‐old male patient presented with a sudden exfoliation of almost all the teeth in his right mandible 2 days prior. Three weeks before this event, he had been diagnosed with herpes zoster infection, which led to irreversible necrosis on the right side of his mandible over 3 months. He was subsequently diagnosed with the osteonecrosis of the right mandible following herpes zoster infection and received aggressive treatment including medication, laser therapy and surgery. We present here our insights into the risk factors, differential diagnosis, pathogenesis and treatment options for this rare complication based on our case and latest literature review.
Edge reconstruction and feature enhancement‐driven architecture for blind super‐resolution in medical imaging systems
Authors: Li Yinghua , Liu Yue , Xu Jian , Chu Hongyun , He Jinglu , Zhang Shengchuan , Liu Ying 
Published: August 2024

AbstractIn the field of single image super‐resolution, the prevalent use of convolutional neural networks (CNN) typically assumes a simplistic bicubic downsampling model for image degradation. This assumption misaligns with the complex degradation processes encountered in medical imaging, leading to a performance gap when these algorithms are applied to real medical scenarios. Addressing this critical discrepancy, our study introduces a novel degradation comparative learning framework meticulously designed for the nuanced degradation characteristics of medical images within the Internet of Medical Things (IoMT). Unlike traditional CNN‐based super‐resolution approaches that homogeneously process image channels, our method acknowledges and leverages the disparity in informational content across channels. We present a blind image super‐resolution technique, underpinned by edge reconstruction and an innovative image feature supplement module. This approach not only preserves but enriches texture details, crucial for the accurate analysis of medical images in the IoMT. Comparative evaluations of our model against existing blind super‐resolution methods, utilizing both natural image testing datasets and medical images, demonstrate its superior performance. Notably, our approach exhibits remarkable proficiency in stably restoring various degraded super‐resolution images, a critical requirement in the IoMT context. Experimental results demonstrate that our method is superior to the current state‐of‐the‐art methods, marking a significant advancement in the field of medical image super‐resolution.
A multicriteria model for ranking logistics startups during the acquisition process in a transport company
Authors: de Medeiros Marcelo Gonçalves , Cavalcante Rodrigo José Leite , Carneiro de Lima da Silva Anderson Lucas , Reis Peixoto Roselli Lucia 
Published: August 2024

AbstractThe logistics market represents a fundamental segment for the circulation of goods and greater economic activity. Logistics startups have been gaining great importance, being potential substitutes for traditional carriers. Given this context, there is a huge need for large carriers to develop digital and sustainable solutions, and especially to look at inorganic strategies such as mergers and acquisitions. However, the process by which carriers may acquire logistics startups is quite complex. This study sought to solve the problem of ranking logistics startups with the potential to be acquired by the carrier in a Brazilian company through a multi‐criteria approach. The Flexible and Interactive Tradeoff (FITradeoff) method was used to solve the case and a ranking of the startups was obtained. The whole process was quick and simple, so this study contributes to proposing a useful model for logistics problems, and demonstrates the practicality of how to solve them using FITradeoff.
Explaining Injustice: Causation through a Remedial Lens
Authors: Erck Susan 
Published: August 2024

ABSTRACTWhen devising a plan of remedial action to address an ongoing injustice, it is desirable to possess an understanding of the key contributing factors and mechanisms that produce and sustain it. This is the domain of etiology of injustice. Etiology of injustice involves practices of causal selection that give explanatory priority to the operative causation of the injustice at issue. Operative causation refers to those processes and conditions that might be changed for the injustice to cease and to be sufficiently prevented in the future. This article uses causal selection criteria to theorize the ways in which a remedial orientation toward the explanandum of injustice determines the parameters of explanatory relevance.
Hidden structural information reconstruction and seismic response analysis of high‐rise residential shear wall buildings with limited structural data
Authors: Zhang Chenyu , Wen Weiping , Zhai Changhai , Wei Yuqiu , Ruan Penghao 
Published: August 2024

AbstractThe high‐rise residential shear wall structure is a crucial component of urban building clusters, while the limited availability of detailed structural information becomes a critical bottleneck in improving the accuracy of seismic performance assessment for high‐rise residential shear wall buildings in urban areas. Based on easily obtainable yet limited structural data at the urban scale, this paper proposes a method to address the shortcomings of existing research on reconstructing hidden structural information and enhance the accuracy of structural seismic performance assessment. It includes a physics‐constrained generative adversarial network module and a fuzzy inference system module to reconstruct the spatial arrangement of shear walls, and material strength grades within buildings, respectively. Validated against two actual buildings, the method outperforms the widely used simplified analysis method at the urban scale, achieving 85.9% accuracy in predicting damage states across various floors.