bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysis
Authors: Keeney Grant E. , Gray Matthew P. , Morrison Andrea K. , Levas Michael N. , Kessler Elizabeth A. , Hill Garick D. , Gorelick Marc H. , Jackson Jeffrey L. 
Published: February 2014

BACKGROUND AND OBJECTIVE:
Dexamethasone has been proposed as an equivalent therapy to prednisone/prednisolone for acute asthma exacerbations in pediatric patients. Although multiple small trials exist, clear consensus data are lacking. This systematic review and meta-analysis aimed to determine whether intramuscular or oral dexamethasone is equivalent or superior to a 5-day course of oral prednisone or prednisolone. The primary outcome of interest was return visits or hospital readmissions.

METHODS:
A search of PubMed (Medline) through October 19, 2013, by using the keywords dexamethasone or decadron and asthma or status asthmaticus identified potential studies. Six randomized controlled trials in the emergency department of children ≤18 years of age comparing dexamethasone with prednisone/prednisolone for the treatment of acute asthma exacerbations were included. Data were abstracted by 4 authors and verified by a second author. Two reviewers evaluated study quality independently and interrater agreement was assessed.

RESULTS:
There was no difference in relative risk (RR) of relapse between the 2 groups at any time point (5 days RR 0.90, 95% confidence interval [CI] 0.46–1.78, Q = 1.86, df = 3, I2 = 0.0%, 10–14 days RR 1.14, 95% CI 0.77–1.67, Q = 0.84, df = 2, I2 = 0.0%, or 30 days RR 1.20, 95% CI 0.03–56.93). Patients who received dexamethasone were less likely to experience vomiting in either the emergency department (RR 0.29, 95% CI 0.12–0.69, Q = 3.78, df = 3, I2 = 20.7%) or at home (RR 0.32, 95% CI 0.14–0.74, Q = 2.09, df = 2, I2 = 4.2%).

CONCLUSIONS:
Practitioners should consider single or 2-dose regimens of dexamethasone as a viable alternative to a 5-day course of prednisone/prednisolone.
Trends in Caffeine Intake Among US Children and Adolescents
Authors: Branum Amy M. , Rossen Lauren M. , Schoendorf Kenneth C. 
Published: February 2014

BACKGROUND AND OBJECTIVE:
Physicians and policy makers are increasingly interested in caffeine intake among children and adolescents in the advent of increasing energy drink sales. However, there have been no recent descriptions of caffeine or energy drink intake in the United States. We aimed to describe trends in caffeine intake over the past decade among US children and adolescents.

METHODS:
We assessed trends and demographic differences in mean caffeine intake among children and adolescents by using the 24-hour dietary recall data from the 1999–2010 NHANES. In addition, we described the proportion of caffeine consumption attributable to different beverages, including soda, energy drinks, and tea.

RESULTS:
Approximately 73% of children consumed caffeine on a given day. From 1999 to 2010, there were no significant trends in mean caffeine intake overall; however, caffeine intake decreased among 2- to 11-year-olds (P &lt; .01) and Mexican-American children (P = .003). Soda accounted for the majority of caffeine intake, but this contribution declined from 62% to 38% (P &lt; .001). Coffee accounted for 10% of caffeine intake in 1999–2000 but increased to nearly 24% of intake in 2009–2010 (P &lt; .001). Energy drinks did not exist in 1999–2000 but increased to nearly 6% of caffeine intake in 2009–2010.

CONCLUSIONS:
Mean caffeine intake has not increased among children and adolescents in recent years. However, coffee and energy drinks represent a greater proportion of caffeine intake as soda intake has declined. These findings provide a baseline for caffeine intake among US children and young adults during a period of increasing energy drink use.
Biopolymer Hydrogels Regenerated From Agave Tequilana Waste For Cytocompatable Materials
Authors: Kobayashi Takaomi , Tovar-Carrillo Karla L. , Nakasone Kazuki , Tagaya Motohiro 
Published: February 2014

ABSTRACTAgave fibers were used to elaborate a transparent and flexible cellulose hydrogel films used as scaffold for tissue regeneration and tested by in vitro assays with NIH 3T3 fibroblast cells. Using dimethylacetamide/lithium chloride (DMAc/LiCl) system was possible to obtain cellulose solutions and hydrogel films were prepared by phase inverse method without cross-linker. The concentration of LiCl in the DMAc solution was varied from 4 to 12 wt% in the phase inversion process and then the cytotoxicity was tested for 14 days on the cultivation. The resultant hydrogel films showed better cytocompatibility than the PS dish used as control. The cell growing images showed that the hydrogel films with lower LiCl apparently contained ordered and aggregated fiber orientation. This comparison suggested that the segmental microstructure in the hydrogel films influenced fibroblast cells spreading. In addition, the agave hydrogel films displayed good stability without biodegradiation through the cell cultivation.
Controlling Environment and Contact Materials to Optimize Ohmic Microrelay Lifetimes
Authors: Brand Vitali , Baker Michael S , de Boer Maarten P 
Published: February 2014

ABSTRACTThere has been a recent resurgence in interest in developing ohmic switches to complement transistors in order to address challenges associated with electrical current leakage. A critical limitation in ohmic switches remains the reliability of their electrical contacts. These contacts are prone to hydrocarbon induced contamination which progressively inhibits signal transmission, eventually leading to device failure. We report on progress made towards controlling the contamination phenomenon. We discuss how contact materials and operating environment affect device performance, showing that RuO2 coated microswitch contacts operating in the presence of O2 experience very limited contaminant accumulation even in hydrocarbon-rich environments. We then demonstrate that devices which have experienced contamination can recover their original performance by being operated in clean N2:O2 environment. Finally, we suggest that this resistance recovery is associated with the chemical transformation of the contaminant as opposed to its removal and that the transformed contaminant may shield the Pt coating from oxidation.
Shape and Fantasy of Fullerenes
Authors: Ōsawa Eiji , Yoshida Mitsuho , Fujita Mitsutaka 
Published: February 2014

One of the many wonders that fullerenes have brought to us during the past few years is the variety of their shapes. When the elusive C60 finally showed up in 1990, the perfect symmetry and astounding beauty of its molecular structure touched the hearts of scientists before they could consider the molecule's vast technical possibilities. Already much has been said about the unique shape of C60 and its potentialities. C70 and higher fullerenes have simultaneously been found in the same soot that produced C60 and were quickly revealed to be shaped like rugby balls or oblong eggs. Hence we were aware that there had to be an extensive series of roundish polyhedral clusters of carbon atoms.Then, in the following year, multilayered tubular fullerenes (Figures 1a and 1b) were discovered by Iijima and were named buckytubes (see the article by Iijima in this issue). Iijima also observed similarly huge and multilayered carbon balls, before C60 was discovered. Soon after, buckyonions were recognized as an important class of fullerene (Figure 1c, see article by Ugarte in this issue). So, in the early days of fullerene research, we already knew three forms of fullerene: sphere, tube, and particle. At that time, however, nobody anticipated that this was only the beginning of a big show of stunning variations in the shapes of fullerenes. This article introduces current developments in the study of these fullerene styles.
Preparing Monodisperse Metal Powders in Micrometer and Submicrometer Sizes by the Polyol Process
Authors: Fievet F. , Lagier J.P. , Figlarz M. 
Published: February 2014

One of the newer tendencies in materials science has been to tailor-make classical products (long associated with old applications) with controlled properties for special uses, especially in high technology. Preparing dispersed systems in which all particles have nearly uniform size (monodisperse solids) is a typical example. This goal can be achieved in some cases through cleverly controlled particle growth from a liquid medium. Examples of such preparations include gold colloids prepared by Zsigmondy and later by Turkevich et al., sulfur sols obtained by LaMer, metal oxides and hydrous oxides prepared by Matijević et al., silica, etc. These dispersions have been used either to check theories of colloid science, or to a lesser extent, for industrial purposes. In the case of fine metal particles, a uniform size distribution associated with a low degree of agglomeration, and sometimes the spherical shape, appear as particularly convenient characteristics for certain applications. The production of conductive inks or pastes for electronic materials and for the preparation of conductive paints are particularly good examples.In so-called thick film technology, conductive inks and pastes are screen printed on a ceramic substrate in order to form, after firing, a conductive film with a thickness less than 10 μm. This technique is, for instance, used to form the network in hybrid integrated circuits or the internal electrodes of multilayer ceramic capacitors.Metallic powders in thick film compositions are usually precious metals (Au, Ag, Pt, Pd), their mixtures, or alloys. Cheaper metals such as copper or nickel are tested and may be potential substitutes for precious metals in different specific applications. Powders for thick film composition are mainly obtained through chemical precipitation from aqueous or organic solutions, which yield high purity powders. Modification of precipitation parameters (such as the nature and the concentration of the starting metallic compound and of the reducing agent, reaction temperature, viscosity of the medium) and the addition of additives and surfactants, can often be used to control particle size and agglomeration.Over the past few years, we have developed a new process for preparing finely divided metal powders of easily reducible metals (such as precious metals and copper) or less reducible metals (such as cobalt, nickel, cadmium, or lead) by precipitation in liquid polyols. This reaction will be used as an example in order to discuss the mechanism of formation of uniform micrometer and submicrometer size metal particles by precipitation reactions.
Effectiveness of Financial Incentives in a Worksite Diabetes Prevention Program
Authors: Faghri Pouran D. , Li Rui 
Published: February 2014

Purpose:
To evaluate the effect of financial incentive in a diabetes prevention weight loss program at worksites.

Design:
Group-level randomized intervention study.

Setting:
Four long term care facilities, randomly assigned to “incentive-IG” or “non incentive- NIG” groups.

Participants:
Ninety-nine employees, all overweight or obese (BMI= mean 34.8+7.4 kg/m2) and at risk for type 2 diabetes.

Intervention:
A 16 weeks weight loss program (diabetes prevention program) with a 3 month follow up. IG could either choose a "standard incentive" to receive cash award when achieving the projected weight loss or to participate in a "standard plus deposit incentive" to get additional money matched with their deposit for projected weight loss. All of the participants received a one-hour consultation for a healthy weight loss at the beginning.

Measures:
Weight-loss, diabetes risk score (DRS), and cardiovascular risk outcomes. Analyses: Linear and logistic regressions for completed cases with adjustments for clustering effect at group level.

Results:
IG lost on average more pounds (p=0.027), reduced BMI (p=0.04), and reduced in DRS (p=0.011) compared to NIG at week 16. At the 12-week follow-up period, those in IG plus deposit subgroup had twice the odds (OR=2.2, p=0.042) and those in the standard IG had three times the odds of achieving weight loss goals than NIG; those in the IG plus deposit group reduced DRS by 0.4 (p=0.045).

Conclusion:
Monetary incentives appear to be effective in reducing weight and diabetes risk.
Protecting Travelers from Typhoid Fever
Authors: Rao Nalini 
Published: February 2014

Typhoid fever is unique to humans. It remains a significant health problem in many developing countries, and poses a risk to travelers who visit such endemic regions. The proportion of cases acquired in foreign countries has continued to rise, reaching 70% in 1984. The risk of typhoid fever should not be underestimated as a travel-related illness.The incidence of typhoid fever in the united states has decreased from one case per 100,00 population in 1955 to about 0.2 cases per 100,000 in 1966, and has since remained the same. However, international travelers account for more than two-thirds of the reported cases. The percentage of imported cases increased from 33% during 1967 through 1972, to 70% during 1983 through 1984. The majority of the imported cases were from mexico (39%) and india (15%). During the decade 1975 through 1984, 43% of travel-associated cases were non-U.S. citizens. the risk of acquiring typhoid varied from country to country and was the highest for travelers to india and pakistan, with over 400 cases per million, compared with mexico, with 34 per million, and europe, with 0.6 cases per million travelers.
Statistical Analysis of Stratified 2X2 Tables
Authors: Davis Charles S. 
Published: February 2014

Previous papers in this series have discussed design and analysis issues for epidemiologic data that can be presented in a 2 × 2 table.‘” the primary focus was on methods for determining the extent of association between a dichotomous disease state and a dichotomous risk factor. methods appropriate for cross-sectional, prospective, and retrospective studies using matched or unmatched samples were described.In order to study the association between disease status and a dichotomous risk factor, it is often necessary to take into account other variables that may influence either the disease status or the risk factor. For example, Hemming, Overall, and Britt studied the association between the occurrence of nosocomial infections (risk factor) and mortality (disease status) in a large cohort of infants in a newborn intensive care unit. these authors analyzed the data using methods for summarizing the results from a single 2 × 2 table. However, because very low birth weight is associated strongly with both the acquisition of nosocomial infection and mortality, it may be more appropriate to control or adjust for the effects of birthweight.
Implementation of the Chronic Care Model in Small Medical Practices Improves Cardiovascular Risk but Not Glycemic Control
Authors: Frei Anja , Senn Oliver , Chmiel Corinne , Reissner Josiane , Held Ulrike , Rosemann Thomas 
Published: February 2014

OBJECTIVE
To test whether the implementation of elements of the Chronic Care Model (CCM) via a specially trained practice nurse leads to an improved cardiovascular risk profile among type 2 diabetes patients.

RESEARCH DESIGN AND METHODS
This cluster randomized controlled trial with primary care physicians as the unit of randomization was conducted in the German part of Switzerland. Three hundred twenty-six type 2 diabetes patients (age &gt;18 years; at least one glycosylated hemoglobin [HbA1c] level of ≥7.0% [53 mmol/mol] in the preceding year) from 30 primary care practices participated. The intervention included implementation of CCM elements and involvement of practice nurses in the care of type 2 diabetes patients. Primary outcome was HbA1c levels. The secondary outcomes were blood pressure (BP), LDL cholesterol, accordance with CCM (assessed by Patient Assessment of Chronic Illness Care [PACIC] questionnaire), and quality of life (assessed by the 36-item short-form health survey [SF-36]).

RESULTS
After 1 year, HbA1c levels decreased significantly in both groups with no significant difference between groups (−0.05% [−0.60 mmol/mol]; P = 0.708). Among intervention group patients, systolic BP (−3.63; P = 0.050), diastolic BP (−4.01; P &lt; 0.001), LDL cholesterol (−0.21; P = 0.033), and PACIC subscores (P &lt; 0.001 to 0.048) significantly improved compared with control group patients. No differences between groups were shown in the SF-36 subscales.

CONCLUSIONS
A chronic care approach according to the CCM and involving practice nurses in diabetes care improved the cardiovascular risk profile and is experienced by patients as a better structured care. Our study showed that care according to the CCM can be implemented even in small primary care practices, which still represent the usual structure in most European health care systems.
Cracked Tooth Syndrome in an Unrestored Maxillary Premolar: A Case Report
Authors: Batalha-Silva S , Gondo R , Stolf SC , Baratieri LN 
Published: February 2014

SUMMARYCracked tooth syndrome is known to occur most frequently in heavily restored teeth. Nevertheless, when the symptoms occur in intact teeth, there is difficulty in obtaining a correct diagnosis because it is difficult for the dentist to find where the crack is located. This clinical report describes the diagnostic procedures and the direct bonded composite restoration used to restore an incompletely fractured unrestored maxillary premolar in a 22-year-old female patient. To achieve a correct diagnosis, the following were performed: periapical and bitewing radiographs, percussion and thermal vitality tests, a bite test, and the placement of a stainless steel band. Once the symptoms ceased with band placement, cone beam computed tomography, transillumination, macro photographs, and isolation with a rubber dam helped to visualize the crack line along the occlusal surface involving distal and mesial marginal ridges. The crack was traced using a high-speed tungsten carbide bur until the fracture line was not visible. The tooth was restored with a direct composite resin, associated with a total-etch adhesive system, and the symptoms were immediately eliminated.
Influence of caffeine and temperature on corrosion-resistance of CoCrMo alloy
Authors: Romas Manuela , Munoz Anna , Mareci Daniel , Vidal Carlos , Curteanu Silvia , Sutiman Daniel 
Published: February 2014

AbstractThe inhibitory activity of caffeine (1,3,7-trimethyl xanthine) on artificial saliva was studied on a CoCrMo alloy using different electrochemical methods: open circuit potential (OCP), potentiodynamic measurements and electrochemical impedance spectroscopy (EIS). The results show that caffeine produces an inhibitory effect on the anodic currents due to its adsorption on the surface of the alloy. Temperature is another parameter with an influence on corrosion processes, so thermodynamic data were obtained from Arrhenius plots and Langmuir adsorption isotherms. The protective action of caffeine is enhanced at high temperatures at OCP, while for potentiodynamic experiments high temperatures block the inhibitory activity of caffeine and the corrosion rate increases. The process may also be studied by a simulation, determining the functional dependence between OCP, corrosion current density (i corr), corrosion potential (E corr), breakdown potential (E bd) and temperature and amount of caffeine in artificial saliva, for Heraenium® CE. The neural network-based methodology applied in this work provides accurate results, thus proving to be an efficient modelling technique.
A Decade of HIV-1 Drug Resistance in the United States: Trends and Characteristics in a Large Protease/Reverse Transcriptase and Co-Receptor Tropism Database from 2003 to 2012
Authors: Paquet Agnes C , Solberg Owen D , Napolitano Laura A , Volpe Joseph M , Walworth Charles , Whitcomb Jeannette M , Petropoulos Christos J , Haddad Mojgan 
Published: February 2014

Background Drug resistance testing and co-receptor tropism determination are key components of the management of antiretroviral therapy for HIV-1-infected individuals. The purpose of this study was to examine trends of HIV-1 resistance and viral evolution in the past decade by surveying a large commercial patient testing database. Methods Temporal trends of drug resistance, viral fitness and co-receptor usage among samples submitted for routine phenotypic and genotypic resistance testing to protease inhibitors (PIs), nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), as well as for tropism determination were investigated. Results Within 62,397 resistant viruses reported from 2003 to 2012, we observed a decreasing trend in the prevalence of three-class resistance (from 25% to 9%) driven by decreased resistance to PIs (43% to 21%) and NRTIs (79% to 57%), while observing a slight increase in NNRTI resistance (68% to 75%). The prevalence of CXCR4-mediated entry among tropism testing samples ( n=52,945) declined over time from 47% in 2007 to 40% in 2012. A higher proportion of CXCR4-tropic viruses was observed within samples with three-class resistance (50%) compared with the group with no resistance (36%). Conclusions Decreased prevalence of three-class resistance and increased prevalence of one-class resistance was observed within samples reported between 2003 and 2012. The fraction of CXCR4-tropic viruses has decreased over time; however, CXCR4 usage was more prevalent among multi-class-resistant samples, which may be due to the more advanced disease stage of treatment-experienced patients. These trends have important implications for clinical practice and future drug discovery and development.
Plasma Lopinavir Concentrations Predict Virological Failure in a Cohort of South African Children Initiating a Protease-Inhibitor-Based Regimen
Authors: Moholisa Retsilisitsoe R , Schomaker Michael , Kuhn Louise , Meredith Sandra , Wiesner Lubbe , Coovadia Ashraf , Strehlau Renate , Martens Leigh , Abrams Elaine J , Maartens Gary , McIlleron Helen 
Published: February 2014

Background Poor adherence to antiretroviral therapy contributes to pharmacokinetic variability and is the major determinant of virological failure. However, measuring treatment adherence is difficult, especially in children. We investigated the relationship between plasma lopinavir concentrations, pretreatment characteristics and viral load >400 copies/ml. Methods A total of 237 HIV-infected children aged 4–42 months on lopinavir/ritonavir oral solution were studied prospectively and followed for up to 52 weeks. Viral load and lopinavir concentration were measured at clinic visits 12, 24, 36 and 52 weeks after starting treatment. Cox multiple failure events models were used to estimate the crude and adjusted effect of lopinavir concentrations on the hazard of viral load >400 copies/ml. Results The median (IQR) pretreatment CD4+ T-lymphocyte percentage was 18.80% (12.70-25.35) and 53% of children had a pretreatment viral load >750,000 copies/ml. The median (IQR) weight-for-age and height-for-age z-scores were -2.17 (-3.35—2.84) and -3.34 (-4.57—3.41), respectively. Median (IQR) lopinavir concentrations were 8.00 mg/l (4.11-12.42) at median (IQR) 3.50 h (2.67-4.25) after the dose. The hazard of viral load >400 copies/ml was increased with lopinavir concentrations <1 mg/l versus ≥1 mg/l (adjusted hazard ratio 2.3 [95% CI 1.63, 3.26]) and lower height-for-age z-scores. Conclusions Low lopinavir concentrations (<1 mg/l) are associated with viraemia in children. This measure could be used as a proxy for adherence and to determine which children are more likely to fail.