bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity and Reliability of a Systematic Database Search Strategy to Identify Publications Resulting From Pharmacy Residency Research Projects
Authors: Kwak Namhee , Swan Joshua T. , Thompson-Moore Nathaniel , Liebl Michael G. 
Published: January 2015

Purpose: This study aims to develop a systematic search strategy and test its validity and reliability in terms of identifying projects published in peer-reviewed journals as reported by residency graduates through an online survey. Methods: This study was a prospective blind comparison to a reference standard. Pharmacy residency projects conducted at the study institution between 2001 and 2012 were included. A step-wise, systematic procedure containing up to 8 search strategies in PubMed and EMBASE for each project was created using the names of authors and abstract keywords. In order to further maximize sensitivity, complex phrases with multiple variations were truncated to the root word. Validity was assessed by obtaining information on publications from an online survey deployed to residency graduates. Results: The search strategy identified 13 publications (93% sensitivity, 100% specificity, and 99% accuracy). Both methods identified a similar proportion achieving publication (19.7% search strategy vs 21.2% survey, P = 1.00). Reliability of the search strategy was affirmed by the perfect agreement between 2 investigators (k = 1.00). Conclusion: This systematic search strategy demonstrated a high sensitivity, specificity, and accuracy for identifying publications resulting from pharmacy residency projects using information available in residency conference abstracts.
Candida Glabrata and Candida Tropicalis in an Immunocompetent Patient
Authors: Hamilton Leslie A. , Lockhart Nicholas R. , Crain Michael R. 
Published: January 2015

Objective: To report a case of Candida glabrata and tropicalis pneumonia in an immunocompetent patient. Case Summary: A 72-year-old male was transferred from an outside institution due to worsening respiratory status, acute kidney injury secondary to intravenous contrast media, sepsis, and pneumonia with fever and leukocytosis. Upon admission, he was initiated on treatment for hospital-acquired pneumonia, but was also concomitantly tested for many other opportunistic infections due to his recent month-long trip to Ecuador where he participated in a tribal treatment for neuropathy that involved direct exposure to dead guinea pigs. With completion of cultures and bronchoalveolar lavage, C. glabrata was identified in the blood culture and C. glabrata and C. tropicalis in the bronchoalveolar lavage specimen. One month later, he was admitted due to recurrent pneumonia. The patient unfortunately expired during the second admission, due to complications from chronic respiratory pulmonary disease and pneumonia. Discussion: Initially, this patient was treated for hospital-acquired pneumonia, but due to a recent trip to Ecuador, it was soon discovered that this patient had developed an invasive Candida pneumonia. His pulmonary biopsies showed growth of invasive C. glabrata and C. tropicalis, while his blood culture showed C. glabrata. Candida-related lower respiratory tract infections are exceptionally rare in immunocompetent patients and require histopathologic evidence to confirm the diagnosis. A second blood culture showed that the C. glabrata was still present and the patient had worsening leukocytosis, so micafungin was added to his antimicrobial therapy. Conclusion: It is understood that pneumonia is rarely caused by Candida species in patients who are admitted to the hospital. However, health care professionals should be aware that Candida pneumonia should be suspected as part of the differential diagnosis even in immunocompetent patients, particularly if they have recently traveled outside the United States.
Anaplastic lymphoma kinase (ALK) gene alteration in signet ring cell carcinoma of the gastrointestinal tract
Authors: Alese Olatunji B. , El-Rayes Bassel F. , Sica Gabriel , Zhang Guojing , Alexis Dianne , La Rosa Francisco G. , Varella-Garcia Marileila , Chen Zhengjia , Rossi Michael R. , Adsay Nazim V. , Khuri Fadlo R. , Owonikoko Taofeek K. 
Published: January 2015

Objectives: ALK-EML4 translocation is an established driver aberration in non-small cell lung cancer (NSCLC), with reported predilection for cases with signet ring histology. We assessed the presence of anaplastic lymphoma kinase (ALK) gene rearrangements in signet ring cancers arising in the stomach and colon. Methods: Histologically confirmed cases of signet ring adenocarcinoma of the stomach or the colon were identified. The presence of the classic ALK and EML4 fusion gene was initially determined by fluorescence in-situ hybridization (FISH) technique. Immunohistochemistry (IHC) was performed using two previously validated antibodies, ALK1 clone (1:100; DAKO) and 5A4 (Novocastra, Leica Biosystems) along with positive controls of ALK-translocated lung cancer. Results: We employed 42 cases of signet ring carcinoma diagnosed between 2001 and 2011; 25 gastric and 17 colon cancer. Median age 63.3 years; male/female 17/25; race, black 47.5%, white 47.5%, others, 5%; stage I, 21.4%; stage II, 31%; stage III, 26.2%; stage IV, 21.4%. One of 42 cases (2.3%) was positive for ALK translocation by FISH using the standard criteria of at least 15% positive cells for the break-apart signal (50–70 cells enumerated per case). Using a less restrictive cut-off of 10% positive cells, 7 cases (16%) were considered possibly positive. None of the ‘possibly positive’ cases was found to harbor ALK translocation by another molecular testing approach (IHC). IHC with two previously validated monoclonal antibodies showed 0 of 42 (0%) cases positive. Conclusions: ALK gene rearrangement is very rare in gastrointestinal cancers and enrichment strategy focusing on signet ring cell histology did not significantly improve the detection rate.
The Risotto sign – a severe inflammatory bursitis with rice body formation, complicating a rotator cuff repair with a bioabsorbable suture anchor
Authors: Sivaloganathan Sivan , Amr Romel , Shrivastava Raj , Relwani Jaikumar 
Published: January 2015

Lesson There is an association between inflammatory bursitis with rice body formation and use of bioabsorbable suture anchors.
Integration of a Kampo Medicine, Nijutsuto, and Western Medical Treatment in the Treatment of Long-term Frozen Shoulder Refractory to Western Medical Treatment
Authors: Arai Young-Chang , Shimo Kazuhiro , Inoue Masayuki , Sakurai Hiroki , Ohmichi Yusuke , Matsubara Takako , Nishihara Makoto , Kawai Takashi , Ikemoto Tatsunori , Inoue Shinsuke 
Published: January 2015

Objective: Frozen shoulder is a common disorder in general orthopedic practice, characterized by spontaneous onset of pain in the shoulder and accompanied by limitation of glenohumeral movement. Treatments for frozen shoulder include shoulder exercise, manual therapy, corticosteroid injection, manipulation under anesthesia, and arthroscopic capsular release. Several patients suffer from some degree of pain and range of motion limitation for up to 10 years even when these treatments are applied. Kampo, a traditional Japanese herbal medicine based on traditional Chinese herbal medicine, has been used for the treatment of pain in Japan. Nijutsuto has been a Kampo formula used to effectively treat frozen shoulder. Methods: Thirteen patients suffering from long-term frozen shoulder refractory to Western medical treatment were administered Nijututo. Results: Almost all patients experienced sound pain relief after Nijutsuto admnistration. There were no severe side effects reported. Conclusion: Nijutsuto combined with an exercise program improved pain intensity in 13 patients with long-term frozen shoulder.
The need for patient‐focused therapy for children and teenagers with allergic rhinitis: a case‐based review of current European practice
Authors: Santos Alexandra F , Borrego Luis Miguel , Rotiroti Giuseppina , Scadding Glenis , Roberts Graham 
Published: January 2015

AbstractAllergic rhinitis is a common problem in childhood and adolescence, with a negative impact on the quality of life of patients and their families. The treatment modalities for allergic rhinitis include allergen avoidance, anti‐inflammatory symptomatic treatment and allergen specific immunotherapy. In this review, four cases of children with allergic rhinitis are presented to illustrate how the recently published EAACI Guidelines on Pediatric Allergic Rhinitis can be implemented in clinical practice.
Carum induced hypothyroidism: an interesting observation and an experiment
Authors: Naghibi Seyede Maryam , Ramezani Mohamad , Ayati Narjess , Zakavi Seyed Rasoul 
Published: January 2015

Abstract

Carum carvi is a widely available herb that has been used as a food additive and as a medication in traditional medicine for many years. Its potential biological effects include analgesic, anti-inflammatory, anti-anxiety and antispasmodic activities. We report a patient with papillary thyroid carcinoma who were under treatment with levothyroxine and experienced an elevated TSH level by ingestion of Carum carvi. TSH level was increased to 60.3 mIU/L with no change in levothyroxine dosage and decreased to normal range after discontinuation of the Carum carvi. Observing this dramatic change in TSH level by carum ingestion, carum carvi capsules was produced and one of the researcher tried the medication on herself with a dose of 40 mg/kg/day. She had a history of hypothyroidism and was taking 100 ugr/day of levothyroxine. TSH was markedly increased 2 weeks after ingestion of Carum carvi and returned to normal range 5 months after discontinuation of it. This case report shows the effect of consumption of Carum carvi in increasing TSH level in hypothyroid patients treating with levothyroxine. The exact mechanism of action of carum carvi remains unknown.
Les Parisiens, la police et les numérotages des maisons, du XVIIIe siècle à l’Empire
Authors: Denis Vincent 
Published: January 2015

La numérotation des maisons est considérée comme une technique innovante et moderne introduite par l’administration militaire et les autorités urbaines dans les années 1760 en France, pour faciliter l’orientation et la circulation des étrangers, ainsi qu’un contrôle plus serré de l’espace urbain. Cet article analyse l’impact de la numérotation des maisons et son usage par les habitants de Paris, de 1780 à 1807, et comment elle a pu changer la manière dont ils expriment leur localisation, physique et sociale, dans la cité. Il est fondé sur le dépouillement des déclarations d’adresse dans les archives de police. Il montre que les Parisiens ont finalement adopté rapidement et massivement le système de numérotage révolutionnaire, inventé pour d’autres fins que permettre aux citadins de se repérer dans la ville. La Révolution a coïncidé avec une transformation majeure dans la manière dont les individus définissent leur position dans l’espace parisien.
House numbering has been considered as a distinctive, innovative feature introduced by military administration and urban authorities by the 1760s in France to make circulation easier for foreigners and enhance a stricter control on urban space. This article tries to assess the use of house numbering by the people of Paris from 1780 to 1807 and how it changed the way they expressed their location, physical and social, in the city. It is based on the declaration of address in police records. The people of Paris quickly and largely adopted the numbering system of the Revolution, although it was never designed to help the city dwellers orient themselves in the capital. The Revolution coincided with a major transformation in the way people defined their position in Paris and their perception of the city.
Correcting for Misspecification in Parameter Dynamics to Improve Forecast Accuracy with Adaptively Estimated Models
Authors: Kolsarici Ceren , Vakratsas Demetrios 
Published: January 2015

Adaptive estimation methods have become a popular tool for capturing and forecasting changing conditions in dynamic environments. Although adaptive models can provide superior one-step-ahead forecasts, their application to multiperiod forecasting is challenging when the underlying parameter variation process is not correctly specified. The authors propose a methodology based on the Chebyshev approximation method (CAM), which provides a parsimonious substitute for the measurement updating process in the forecasting period, to help forecasters improve multiperiod accuracy in the case of parameter variation misspecification. In two empirical applications concerning the sales growth of new brands, CAM exhibits superior forecasting performance compared to a variety of benchmarks. CAM’s properties are further explored through extensive simulations, which suggest that the proposed method is more likely to increase forecast accuracy when parameter variation is more systematic but misspecified because of uncertainty regarding its exact functional form.This paper was accepted by Pradeep Chintagunta, marketing.
MRSA screening in ambulatory upper limb trauma day cases
Authors: O'Neill Tomás , Itte Vinay , Bourke Gráinne 
Published: January 2015

Aims: Approximately 3% of the UK population are carriers for methicillin-resistant Staphylococcus aureus (MRSA). The NHS set a target of reducing MRSA nosocomial infections by 20% in 2012/13. The Department of Health instigated mandatory universal screening for elective and trauma surgery at significant cost and increased resource demand. Patients presenting to our service with simple upper limb trauma requiring day case surgical intervention are included in mandatory universal MRSA screening, despite being discharged post-operatively before any screening result is known. The aim of this study was to examine the effectiveness of mandatory screening in our patient cohort. Methods: We undertook a retrospective audit of 500 consecutive day case upper limb trauma cases that were managed in our hand unit between 1 May and 31 October 2011. Patient demographics, injury, operative intervention, pre-operative MRSA screening result and post-operative wound swab results were examined. Patients with frankly infective conditions such as abscesses and flexor tenosynovitis were excluded. Results: 78% of our patients were male. 91% were less than 60 years old. 98% of patients had a pre-operative MRSA screening swab. None were positive. 2% had positive post-operative swabs for organisms other than MRSA. Conclusion: We approached our trust and successfully proposed that young, ambulatory, day-case upper limb trauma patients be exempt from mandatory screening. At an average throughput of 1000 cases per annum and an estimated cost of £42.50 per MRSA screen, excluding this cohort of patients from mandatory screening has saved approximately £42 500. The true savings would be likely far greater if applied to similar cohorts across the trust, bringing with it a reduction in screening infrastructure.
Public health and wellbeing: A matter for the midwife?
Authors: Crabbe Katy , Hemingway Ann 
Published: January 2015

This paper will provide a critical narrative review of public health interventions in pregnancy and the role of the midwife in public health. The historical and political context of public health and midwifery will be examined to give a background to the current midwifery public health agenda. The article will identify specific public health interventions used in pregnancy by midwives and assess how midwives perceive their role in implementing them. Midwives are important public health practitioners, who alongside other agencies can make a long-term, positive contribution to the life course of women and their families.
Fairy tale midwifery—fact or fiction: The lived experiences of newly qualified midwives
Authors: Reynolds Ellen Kitson , Cluett Elizabeth , Le-May Andree 
Published: January 2015

Aims:To explore the lived experiences of newly qualified midwives through the first 12 months post-registration.Design and method:Digitally recorded semi-structured interviews occurred at the point of registration, 4 and 12 months post-registration with 12 participants from one University on the South Coast of the UK. Analysis and interpretation were achieved using van Manen's methodology combined with an interpretive phenomenological approach.Results:Participants described their journey through the complexities of ‘reality shock’, ‘false promises’, ‘being part of the club’, ‘self-doubt’, ‘struggling’ and being ‘beyond competence’.Conclusion:Newly qualified midwives face changing levels of professional responsibility. They attain either autonomy or support dependent on where they practise. Newly qualified midwives may still be in ‘student mode’ and expect both autonomy and support rather than seek it for themselves.
Views and experiences of nurses and health-care assistants in nursing care homes about the Gold Standards Framework
Authors: Nash Anne , Fitzpatrick Joanne M 
Published: January 2015

Aim: To explore the views and experiences of nurses and health-care support staff about the use of the Gold Standards Framework (GSF) for end-of-life care (EoLC) for older people in nursing care homes (NCHs) with GSF accreditation. Methods: A qualitative descriptive study was conducted with three purposively selected NCHs in London. Individual interviews were conducted with NCH managers (n=3) and in each NCH, a focus group was conducted with registered nurses (RNs) and health-care assistants (HCAs): focus group 1, n=2 RN, n=2 HCA; focus group 2, n=2 RN, n=3 HCA; focus group 3, n=3 RN, n=3 HCA. Interviews were audio-recorded, transcribed and analysed using framework analysis. Findings: Three core themes were identified: (i) a positive regard for the GSF for care homes (GSFCH); (ii) challenges around EoLC for older people; and (iii) difficulties in using the GSFCH. Conclusions: RNs, HCAs and managers regarded the training and support afforded by the GSFCH programme to inform EoLC for older residents positively. The framework has the potential to promote a coordinated approach to EoLC for older people. In the post accreditation period, there is a need for ongoing support and development to help embed the key tenets of the GSFCH in the culture of caring.
Therapist's influence on the design of Invacare's Flo-Tech Solution Xtra
Authors: Hall Sarah 
Published: January 2015

The trend for inclusive design appears to becoming stronger, and an area that clinicians are urged to participate in. Combining clinical and technical expertise can often be a demanding challenge and this paper looks to show the results of how a modular postural cushion was designed and evaluated by Invacare Ltd. The Flo-Tech Solution Xtra modular system was conceived through joint collaboration between manufacturer and therapists following discussion and demand from NHS wheelchair services (WCS) in the UK. Concept, rationale and design of the cushion are discussed from a clinical perspective, which underpins the manufacturing process from conception through to the finished product. The seating system was designed to address the postural requirements primarily of the neurological population and consequently the cushion underwent clinical trial at the Royal Hospital of Neuro-Disability, Putney, London. Seven subjects were identified as suitable for the evaluation by the postural team at Putney and three were trialed independently by Invacare Ltd. The main focus of this study was identifying and meeting the individual's therapeutic aims of posture and pressure through using the Solution Xtra. Even though the study size was small and the results subjective in nature, there was an overall favourable outcome of using the modular system as a seating intervention, and it was also rated highly by the clinicians involved.
Research into fabrics used in compression therapy and assessment of their impact on treatment regimens
Authors: Hegarty-Craver M. , Grant E. , Kravitz S. , Reid L. , Kwon K. , Oxhenham W. 
Published: January 2015

The objective of this paper is to provide a definition for interface compression that uses essential principles of engineering science. This definition discusses factors that influence the amount of applied pressure, including the size of the limb, the amount of fabric tension (graduated pressure profile), the number of layers, and the material creep characteristics. Laplace's law has been applied to compression therapy. Tension-extension profiles have been derived for different types of compression fabric to demonstrate the effects of resistance and friction. Force-time profiles have been derived for different types of fabric compression systems to demonstrate the effects of creep (creep is defined generally as the irreversible deformation of a material over time in the presence of a constantly applied load). Here, the fabric compression systems were applied to a test-bed that supplied a constant force to the fabric; creep was taken as the loss of compression (pressure) over time. Laplace's law has been interpreted for compression therapy. The amount of fabric tension is determined by the extent to which it is stretched during application, as well as by changes in the size of the limb. The fabric's relative elasticity, which is quantified by the rigidity index and is related to the slope of the tension-extension profile, dictates the amount that the applied force changes with extension. Compression systems that use multiple layers of fabric are generally more resistive to stretching than single-layer systems. Friction acting between the layers, as well as the added force from each layer, serves to increase the overall compression of these systems. As the applied force rises, the amount of pressure supplied by the fabric increases. However, when the same force (or fabric extension) is used, the applied pressure is less when distributed over a larger surface area. In other words, as the circumference of the limb increases, the pressure decreases. This is the driving principle behind graduated compression. In addition to the changes in fabric tension resulting from extension, the creep characteristics of the material affect the amount of compression provided throughout the wear cycle. The factors influencing interface compression are multi-faceted. Based upon the interpretation of the material properties of compression fabrics (tension-extension profile, number of fabric layers, and creep), new therapeutic guidelines have been established, and others clarified. Declaration of interest: This study was sponsored by Carolon. L. Reid, and S. Kravitz are employees of Carolon and E. Grant is a Member of the Board. M. Hegarty-Craver and C. Kwon have received monetary compensation as researchers for Carolon.
IEDs and a Jack-in-the-Box: The mystery of motivation in The Hurt Locker (2008)
Authors: Deutelbaum Marshall 
Published: January 2015

Abstract
Though based upon his non-fiction article ‘The Man in the Bomb Suit’, published in Playboy in 2005, the dramatic structure of Mark Boal’s script for The Hurt Locker (2008) is eccentric, only revealing its true subject, the motivation of its central character for being a bomb technician, just before its ending. In comparison with the clarity of motivations in Paul Haggis’ script for In the Valley of Elah (2007), adapted by him from an earlier non-fiction essay by Boal that also takes place during the Iraq war, the script for The Hurt Locker deviates decidedly from the format of classical Hollywood narrative; because he lacks a clearly defined goal, the psychology and motivations of the central character remain obscure. Indeed a comparison of the final script with an earlier version readily illustrates how rigorously insights into the character’s motivations, and his self-awareness, were reduced. As a result, The Hurt Locker in its final version asks considerably more imaginative and intellectual engagement from its viewers than most commercial cinema.