bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research‐informed counselling and psychotherapy: A training and accreditation agenda
Authors: Cooper Mick , McLeod John , Smith Kate 
Published: July 2024

AbstractTraining and accreditation standards play a critical role in the development of a research‐informed agenda. This commentary on Barkham et al. (Counselling and Psychotherapy Research, 2024) discusses obstacles to fully integrating research into the training and standard agendas, and the potential role that the British Association for Counselling and Psychotherapy (BACP) can play in helping to overcome such obstacles. Knowledge of research evidence is currently limited in training and accreditation standards for counselling and psychotherapy, and course tutors are often not familiar—or engaged—with research findings. In the development of professional standards (for instance, within SCoPEd), the BACP should work to ensure that research competencies are comprehensive, contemporary and explained in a granular manner. Further helpful developments might include an annual research‐oriented conference for trainers and clinical supervisors, a journal dedicated to disseminating research and good practice in training and clinical supervision and/or a training/clinical supervision research network to coordinate activities in these area. BACP events—across all elements of the profession—should strive to address issues of research awareness and participation, and the use of research to inform practice. Critically, across all of these possibilities, BACP's Research Department, alone, cannot be left to support moves to a research‐informed profession. Rather, an organisation‐wide initiative is needed in which appreciation of the research evidence is at the heart of all aspects of the Association's work.
‘Am I both or not?’: The role of perceived societal norms of multiculturalism in negotiating bicultural identities
Authors: Ng Tseung‐Wong Caroline , Ward Colleen , Szabó Ágnes 
Published: July 2024

AbstractThe present study explored the role of perceived societal norms of multiculturalism in the engagement of cultural identity styles (hybridising‐HIS and altenating‐AIS) and, in turn, their impact on bicultural identity consolidation and cultural identity conflict. We examined 293 Chinese Americans' perceptions about the extent to which culturally diverse groups are in contact with one another (multicultural contact); whether diversity is valued and appreciated (multicultural ideology); and whether there are policies and practices that support and accommodate diversity (multicultural policies and practices) in the United States. Results from a path analysis showed that multicultural ideology was negatively associated with AIS and cultural identity conflict. Multicultural contact was positively associated with HIS and bicultural identity consolidation. Multicultural policies and practices had no significant associations. The findings underscore the important role of perceived societal acceptance of multicultural ideology and perceived norms of multicultural contact in managing cultural identities. Furthermore, the study highlights that perceived multiculturalism norms as societal‐level factors combined with individual‐level cultural identity styles can influence the identity outcomes of multicultural individuals. Further research into the role of perceived societal norms for both majority and cultural minority individuals in identity integration is warranted.
Comparison of Anticancer, Antioxidant, Enzyme Inhibitory Effects and Phytochemical Contents Between Edible Lettuce (Lactuca sativa) and a New Wild Species (Lactuca anatolica)
Authors: Erdogan Mehmet Kadir , Gundogdu Ramazan , Toy Yusuf , Halil Gecibesler Ibrahim , Yapar Yakup , Behcet Lutfi , Zengin Gokhan 
Published: July 2024

AbstractIn this study, the bioactive components, enzyme inhibitory, antioxidant and anticancer potentials of edible (L. sativa) and a new species (L. anatolica) of Lactuca were evaluated and compared. The quantitative analyzes of the bioactive components of L. sativa (LS) and L. anatolica (LA) were analyzed quantitatively by GC‐MS and Orbitrab HPLC‐HRMS. Antioxidant, enzyme inhibitory and anticancer properties were analyzed by various assays. In general, LA exhibited more stronger antioxidant properties compared to LS. The extracts showed similar inhibitory effects on these enzymes. It was determined that LS was dominant in terms of linoleic acid (23.71 %), while LA contained a high level of α‐linolenic acid (31.70 %). LA and LS inhibited the viability of A549 and MCF‐7 cells in a dose‐dependent manner. IC50 values for LA, LS and cisplatin were determined as 120.3, 197.5, 4.3 μg/mL in A549 cell line and 286.2, 472.8, 7.2 μg/mL in MCF‐7 cell line, respectively. It was revealed that LA and LS treatment at 50 μg/mL concentrations in A549 cells completely suppressed the colony forming capacity, and treatment with IC50 doses inhibited cell migration, and triggered apoptosis by regulating caspase‐3, cPARP, p53 and p21. The findings of this study suggested that these species have significant pharmacological potential.
Structural Basis of the Dehydratase Module (hDH) of Human Fatty Acid Synthase
Authors: Cai Chang , Huang Yuzhou , Zhang Lin , Zhang Liang 
Published: July 2024

AbstractThe human fatty acid synthase (hFASN) produces fatty acids for cellar membrane construction, energy storage, biomolecule modifications and signal transduction. Abnormal expression and functions of hFASN highly associate with numerous human diseases such as obesity, diabetes, and cancers, and thereby it has been considered as a valuable potential drug target. So far, the structural and catalytic mechanisms of most of the hFASN enzymatic modules have been extensively studied, except the key dehydratase module (hDH). Here we presented the enzymatic characterization and the high‐resolution crystal structure of hDH. We demonstrated that the hDH preferentially catalyzes the acyl substrates with short lengths between 4 to 8‐carbons, and exhibits much lower enzymatic activity on longer substrates. Subsequent structural study showed that hDH displays a pseudo‐dimeric organization with a single L‐shaped composite hydrophobic catalytic tunnel as well as an atypical ACP binding site nearby, indicating that hDH achieves distinct substrate recognition and dehydration mechanisms compared to the conventional bacterial fatty acid dehydratases identified. Our findings laid the foundation for understanding the biological and pathogenic functions of hFASN, and may facilitate therapeutical drug development against diseases with abnormal functionality of hFASN.
Spontaneous omental infarction as a rare differential for right iliac fossa pain: A case report and review of the literature
Authors: Lee Su Jin , Le Khang Duy Ricky , Mark Peter 
Published: July 2024

Key Clinical MessageOmental infarction is a rare cause of acute abdominal pain, often benign and self‐limiting. The significance of infarction lies in the fact that it can mimic other abdominal pathologies including appendicitis, cholecystitis, pancreatitis, or reflux disease. Diagnostic laparoscopy provides the definitive diagnosis of omental infarction, but it is invasive and limited due to resources. Computed tomography of the abdomen and pelvis has been considered the gold standard to diagnosing omental infarction when a non‐invasive diagnostic approach is required. Additionally, ultrasound can also be used alternatively for children. Currently, there is no consensus in the diagnosis and management of patients with imaging‐proven omental infarction. Spontaneous infarcted omentum must be considered by surgeons and radiologists as a rare cause of acute abdominal pain as patients can experience good outcomes with either conservative or operative approach. However, conservative management must only be considered in stable patients where alternative pathology is unlikely.image
A rare presentation and treatment challenges for multiple myeloma in down syndrome: A case report and literature review
Authors: Musleh Mais , Alhusein Qossay 
Published: July 2024

Key Clinical MessageDown syndrome (DS), characterized by trisomy 21, significantly increases susceptibility to leukemia, although the occurrence of multiple myeloma (MM) in DS is exceedingly rare. This report details the case of a 45‐year‐old female with DS who was diagnosed with MM, highlighting diagnostic and therapeutic complexities. It emphasizes the importance of tailored therapeutic strategies for treating MM in individuals with DS and the need for specialized approaches in these cases.
One‐year follow‐up of amputation as a curative treatment for body integrity dysphoria: A case report
Authors: Nadeau Nadia 
Published: July 2024

Key Clinical MessageElective amputation as a treatment for Body Integrity Identity Disorder (BIID) or Body Integrity Dysphoria (BID) where noninvasive treatments prove ineffective and the patient's distress is substantial, may permit long‐term remission of symptoms at follow‐up.AbstractWe present the one‐year follow‐up post‐surgery of an ambidextrous male who sought elective amputation of his left hand's fourth and fifth fingers after an unsuccessful trial of psychotherapy and pharmacotherapy for Body Integrity Dysphoria. He had no psychiatric comorbidities. At one‐year follow‐up, his dysphoria was still in remission. He exhibited full adaptation in his social and occupational life, demonstrating increased ease in hand use compared to pre‐amputation. He reported sleeping well, happiness, good health and continued acceptance by friends and family. This one‐year post‐surgery follow‐up, at 22 years old, underscores the efficacy of amputation as a curative treatment, high patient satisfaction, and the quality of life gained through the procedure.
Flexible self‐supporting organic cathode with interface engineering for high‐performance and wide‐temperature sodium‐ion batteries
Authors: Wang Lei , Fang Suqiao , Wang Haichao , Peng Qianqian , Liu Yifeng , Dong Hanghang , Yan Hao , Wang Yong , Chou Shulei , Sun Bing , Xiao Yao , Chen Shuangqiang 
Published: July 2024

AbstractFlexible electrode design with robust structure and good performance is one of the priorities for flexible batteries to power emerging wearable electronics, and organic cathode materials have become contenders for flexible self‐supporting electrodes. However, issues such as easy electrolyte solubility and low intrinsic conductivity contribute to high polarization and rapid capacity decay. Herein, we have designed a flexible self‐supporting cathode based on perylene‐3,4,9,10‐tetracarboxylic dianhydride (PTCDA), interfacial engineering enhanced by polypyrrole (PPy), and carbon nanotubes (CNTs), forming the interconnected and flexible PTCDA/PPy/CNTs using polymerization reaction and vacuum filtration methods, effectively curbing those challenges. When used as the cathode of sodium‐ion batteries, PTCDA/PPy/CNTs exhibit excellent rate capability (105.7 mAh g−1 at 20 C), outstanding cycling stability (79.4% capacity retention at 5 C after 500 cycles), and remarkable wide temperature application capability (86.5 mAh g−1 at −30°C and 115.4 mAh g−1 at 60°C). The sodium storage mechanism was verified to be a reversible oxidation reaction between two Na+ ions and carbonyl groups by density functional theory calculations, in situ infrared Fourier transform infrared spectroscopy, and in situ Raman spectroscopy. Surprisingly, the pouch cells based on PTCDA/PPy/CNTs exhibit good mechanical flexibility in various mechanical states. This work inspires more rational designs of flexible and self‐supporting organic cathodes, promoting the development of high‐performance and wide‐temperature adaptable wearable electronic devices.
Photoinduced Redox Cascade Reaction of Isatins and Aliphatic Carboxylic Acids to Access 6‐Hydroxyindoloquinazolinones
Authors: Dong Chun‐Lin , Liu Han‐Chi , He Yan‐Hong , Guan Zhi 
Published: July 2024

AbstractA visible‐light‐induced cascade reaction is described for the one‐pot synthesis of 6‐hydroxyindoloquinazolinones using isatins (or isatins and isatoic anhydrides) and aliphatic carboxylic acids. The method provides 36 desired products in 33–96 % yield, exhibiting broad substrate scope and good functional group tolerance. This approach utilizes inexpensive and commercially available starting materials, enabling the direct construction of high‐value complex structures under mild conditions without the need for photocatalyst, showcasing significant applicability and environmental friendliness.
Triphenylamine Sensitized 8‐Dimethylaminoquinoline: An Efficient Two‐Photon Caging Group for Intracellular Delivery
Authors: Rigault Delphine , Nizard Philippe , Daniel Jonathan , Blanćhard‐Desce Mireille , Deprez Eric , Tauc Patrick , Dhimane Hamid , Dalko Peter I. 
Published: July 2024

AbstractTriphenylamine‐sensitized 8‐dimethylaminoquinoline (TAQ) probes showed fair two‐photon absorption and fragmentation cross sections in releasing kainate and GABA ligands. The water‐soluble PEG and TEG‐analogs allowed cell internalization and efficient light‐gated liberation of the rhodamine reporter under UV and two‐photon (NIR) irradiation conditions.
Excited‐State Dynamics in Segregated Donor‐Acceptor Stacks Versus a Peri‐Bisdonor‐Acceptor System
Authors: Ramakrishnan Remya , Madhu Meera , Babu Hruidya C. , Sebastian Ebin , Hariharan Mahesh 
Published: July 2024

AbstractThe investigation of impact of through‐space/through‐bond electronic interaction among chromophores on photoexcited‐state properties has immense potential owing to the distinct emergent photophysical pathways. Herein, the photoexcited‐state dynamics of homo‐sorted π‐stacked aggregates of a naphthalenemonoimide and perylene‐based acceptor‐donor (NI‐Pe) system and a fork‐shaped acceptor‐bisdonor (NI‐Pe2) system possessing integrally stacked peri‐substituted donors was examined. Femtosecond transient absorption (fsTA) spectra of NI‐Pe monomer recorded in chloroform displayed spectroscopic signatures of the singlet state of Pe; 1Pe*, the charge‐separated state; NI−⋅‐Pe+⋅, and the triplet state of Pe; 3Pe*. The examination of ultrafast excited‐state processes of NI‐Pe aggregate in chloroform revealed faster charge recombination (
=1.75 ns) than the corresponding monomer (
=2.46 ns) which was followed by observation of a broad structureless band attributed to an excimer‐like state. The fork‐shaped NI‐Pe2 displayed characteristic spectroscopic features of the NI radical anion (λmax~450 nm) and perylene dimer radical cation (λmax~520 nm) upon photoexcitation in non‐polar toluene solvent in the nanosecond transient absorption (nsTA) spectroscopy. The investigation highlights the significance of intrinsic close‐stacked arrangement of donors in ensuring a long‐lived photoinduced charge‐separated state (
=1.35 μs) in non‐polar solvents via delocalization of radical cation between the donors.
Narrowband Blue Circularly Polarized Luminescence Emitter Based on BN‐Doped Benzo[6]helicene with Stimuli‐Responsive Properties
Authors: Liu Meiyan , Li Chenglong , Liao Guanming , Zhao Fenggui , Yao Chunxia , Wang Nan , Yin Xiaodong 
Published: July 2024

AbstractBoron‐doped helicenes, known for their unique electronic and photophysical properties, are of great interest for numerous applications. This research introduces two new azabora[6]helicenes, H[6]BN1 and H[6]BN2, synthesized through an efficient method. These molecules have boron and nitrogen atoms in opposing positions, enhancing their distinctive attributes. Both helicenes show excellent emission properties, with H[6]BN1 and H[6]BN2 exhibiting narrowband blue fluorescence and circularly polarized luminescence (CPL), achieving glum values of 4~5×10−4 which is beneficial for chiroptical applications. The addition of a donor group, 3, 6‐di‐tert‐butyl‐9H‐carbazole, in H[6]BN2 improves luminescence, likely due to enhanced molecular orbital overlap and electron delocalization. H[6]BN1′s needle‐like single crystals exhibit mechanochromism, changing luminescent color from yellow to green under mechanical stress, which is promising for stimulus‐responsive materials. In conclusion, this study presents a novel class of BN[6]helicenes with superior chiroptical properties. Their combination of electronic features and mechanochromism makes them ideal for advanced chiroptical materials, expanding the potential of helicene‐based compounds and offering new directions for the synthesis of molecules with specific chiroptical characteristics.
Aspekte der Energiewende. Teil 3: Energieszenarien für eine vollständig defossilisierte deutsche Energieversorgung
Authors: Machhammer Otto , Siebels Carsten 
Published: July 2024

ZusammenfassungAuf Basis des von der Bundesnetzagentur für Elektrizität, Gas, Telekommunikation, Post und Eisenbahnen genehmigten Szenariorahmens 2023‐2037/2045 [1] wurde mithilfe von stündlich aufgelösten Erzeuger‐ und Verbraucherprofilen ein mögliches Bild der Energielandschaft für den Fall einer vollständig defossilisierten Energieversorgung entworfen. Darauf aufbauend wurde die Frage behandelt, ob der dafür benötigte Wasserstoff heimisch erzeugt werden sollte und wie stark dezentrale, haushaltsnahe saisonale Speicher die Niederspannungsnetze entlasten würden. Eine Schätzung liefert Anhaltswerte für den finanziellen Aufwand und den Flächenbedarf zur Erreichung dieses Ziels.
Intracellular Delivery of Antisense Oligonucleotides by Tri‐Branched Cyclic Disulfide Units
Authors: Lyu Fangjie , Hakariya Hayase , Hiraoka Haruka , Li Zhenmin , Matsubara Noriaki , Soo Yonghao , Hashiya Fumitaka , Abe Naoko , Shu Zhaoma , Nakamoto Kosuke , Kimura Yasuaki , Abe Hiroshi 
Published: July 2024

AbstractTherapeutic oligonucleotides, such as antisense DNA, show promise in treating previously untreatable diseases. However, their applications are still hindered by the poor membrane permeability of naked oligonucleotides. Therefore, it is necessary to develop efficient methods for intracellular oligonucleotide delivery. Previously, our group successfully developed disulfide‐based Membrane Permeable Oligonucleotides (MPON), which achieved enhanced cellular uptake and gene silencing effects through an endocytosis‐free uptake mechanism. Herein, we report a new molecular design for the next generation of MPON, called trimer MPON. The trimer MPON consists of a tri‐branched backbone, three α‐lipoic acid units, and a spacer linker between the oligonucleotides and tri‐branched cyclic disulfide unit. We describe the design, synthesis, and functional evaluation of the trimer MPON, offering new insights into the molecular design for efficient oligonucleotide delivery.
Introducing the Bis(mesitoyl)phosphide Ligand into Dinuclear Trivalent Rare Earth Metal Coordination Chemistry
Authors: Deshapriya Saroshan , Delano Francis , Demir Selvan 
Published: July 2024

AbstractAnionic ancillary ligands play a critical role in the construction of rare earth (RE) metal complexes due to the large influence on the stability of the molecule and engendering emergent electronic properties that are of interest in a plethora of applications. Supporting ligands comprising oxygen donor atoms are highly pursued in RE chemistry owing to the high oxophilicity innate to these ions. The scarcely employed bis(acyl)phosphide (BAP) ligands feature oxygen coordination sites and contain a phosphide backbone rendering it attractive for RE‐coordination chemistry. Here, we integrate bis(mesitoyl)phosphide (mesBAP) as an ancillary ligand into REIII chemistry to generate the first dinuclear trivalent RE complexes containing BAP ligands; [{mesBAP}2RE(THF)(μ‐Cl)]2 (RE=Y, (1), Gd (2), and Dy (3); THF=tetrahydrofuran). Each RE center is ligated to two monoanionic mesBAP ligands, one THF molecule and one chloride ion. All three molecules were characterized through single‐crystal X‐ray diffraction, 31P NMR, IR and UV‐Vis spectroscopy. 31P, 1H and 13C NMR on the diamagnetic yttrium congener 1 confirm asymmetric ligand coordination. DFT calculations conducted on 2 provided insight into the electronic structure. The magnetic properties of 2 and 3 were investigated via SQUID magnetometry. The GdIII ions exhibit weak antiferromagnetic coupling, corroborated by DFT results.
A floating‐point multiplier based on angle representation method
Authors: Gan Bo , Wang Kang , Wang Guangsen , Zheng Huiji , Chen Guoyong 
Published: July 2024

SummaryThis article proposes a novel angle representation method for floating‐point number, which eliminates the need for DSP (Digital Signal Processor) resources and reduces the resource usage when performing floating‐point multiplication. Compared with the implementation of floating‐point multiplier using IP cores, the implementation of approximate multiplication based on lookup tables can achieve an average reduction of 58.2% in LUTs (look‐up tables) and an average increase of 20.4% in frequency for mantissa widths ranging from 3 to 12 bits. Additionally, it can also save an average of 23.2% in registers. Analysis of PDP (power‐delay product)/LUT to MRED (mean relative error distance)/PRED (probability of relative error distance) among other approximate multipliers shows that the proposed design extends the Pareto front. At last, simulation of a three‐level inverter is implemented to verify the effectiveness of the multiplier.
Develop and validate a computable phenotype for the identification of Alzheimer's disease patients using electronic health record data
Authors: He Xing , Wei Ruoqi , Huang Yu , Chen Zhaoyi , Lyu Tianchen , Bost Sarah , Tong Jiayi , Li Lu , Zhou Yujia , Li Zhao , Guo Jingchuan , Tang Huilin , Wang Fei , DeKosky Steven , Xu Hua , Chen Yong , Zhang Rui , Xu Jie , Guo Yi , Wu Yonghui , Bian Jiang 
Published: July 2024

AbstractINTRODUCTIONAlzheimer's disease (AD) is often misclassified in electronic health records (EHRs) when relying solely on diagnosis codes. This study aimed to develop a more accurate, computable phenotype (CP) for identifying AD patients using structured and unstructured EHR data.METHODSWe used EHRs from the University of Florida Health (UFHealth) system and created rule‐based CPs iteratively through manual chart reviews. The CPs were then validated using data from the University of Texas Health Science Center at Houston (UTHealth) and the University of Minnesota (UMN).RESULTSOur best‐performing CP was “patient has at least 2 AD diagnoses and AD‐related keywords in AD encounters,” with an F1‐score of 0.817 at UF, 0.961 at UTHealth, and 0.623 at UMN, respectively.DISCUSSIONWe developed and validated rule‐based CPs for AD identification with good performance, which will be crucial for studies that aim to use real‐world data like EHRs.Highlights
Developed a computable phenotype (CP) to identify Alzheimer's disease (AD) patients using EHR data.
Utilized both structured and unstructured EHR data to enhance CP accuracy.
Achieved a high F1‐score of 0.817 at UFHealth, and 0.961 and 0.623 at UTHealth and UMN.
Validated the CP across different demographics, ensuring robustness and fairness.