bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Trisubstituted Isoxazoles via in situ Trapping Strategy from α‐Nitro Carbonyl Compounds and Methyl Ketones or Terminal Aryl Alkenes.
Authors: Yang Yan , Gao Meng , Deng Cong , Zhang Dong‐Xue , Wu Liu‐Ming , Shu Wen‐Ming , Wu An‐Xin 
Published: November 2012

AbstractA novel route for the synthesis of isoxazoles starts from easily available α‐nitroketones and methylketones or terminal aryl alkenes.
ChemInform Abstract: Synthesis of Some Tetrazole‐Fused Pyrido[2,3‐c]coumarin Derivatives from a One‐Pot Three‐Component Reaction via Intramolecular 1,3‐Dipolar Cycloaddition Reaction of Azide to Nitriles.
Authors: Borah Pallabi , Naidu P. Seetham , Bhuyan Pulak J. 
Published: November 2012

AbstractA simple protocol allows the synthesis of various biologically interesting title systems.
ChemInform Abstract: General Non‐catalytic Approach to Spiroacenaphthylene Heterocycles: Multicomponent Assembling of Acenaphthenequinone, Cyclic CH‐Acids and Malononitrile.
Authors: Elinson Michail N. , Ilovaisky Alexey I. , Merkulova Valentina M. , Belyakov Pavel A. , Barba Fructuoso , Batanero Belen 
Published: November 2012

AbstractThis new, convenient, and facile procedure represents the most effective and ′green′ approach to the reliable design of the title compounds.
ChemInform Abstract: Organocatalytic One‐Pot Asymmetric Synthesis of 4H,5H‐Pyrano[2,3‐c]pyrazoles.
Authors: Enders Dieter , Grossmann Andre , Gieraths Bianca , Duezdemir Muharrem , Merkens Carina 
Published: November 2012

AbstractThe title compounds are obtained from α,β‐unsaturated aldehydes, aromatic phosphorus ylides, and pyrazolones in the presence of prolinol‐derived catalyst PRO via an asymmetric Michael/Wittig/oxa‐Michael reaction sequence.
ChemInform Abstract: A Facile and Efficient Synthesis of 2‐Amino‐3‐cyano‐4H‐chromenes and Tetrahydrobenzo[b]pyrans Using 2,2,2‐Trifluoroethanol as a Metal‐Free and Reusable Medium.
Authors: Khaksar Samad , Rouhollahpour Ahmad , Talesh Saeed Mohammadzadeh 
Published: November 2012

AbstractCompounds (IV) are purified by recrystallization.
ChemInform Abstract: Studies on Reactive Pyridylketones Formed by Weinreb Transformations.
Authors: Stockmann Vegar , Kaspersen Svein Jacob , Nicolaisen Alexander , Fiksdahl Anne 
Published: November 2012

AbstractA method for the preparation of reactive pure vinylpyridylketones and activated vinylketones and their use in further reactions such as cycloadditions are described.
ChemInform Abstract: Synthesis of Pyridine‐2,6‐bis((E)‐2‐benzylidene‐3‐oxo‐propanenitrile) and Its Behavior Towards Nitrogen Binucleophiles.
Authors: Ali Korany A. 
Published: November 2012

AbstractCondensation of the bis(β‐keto nitrile) (I) with aromatic aldehydes (II) yields the Knoevenagel products (III).
ChemInform Abstract: Synthesis and Evaluation of 4‐Aryl‐2(1H)‐quinolinones as Potent Amyloid β Fibrillogenesis Inhibitors.
Authors: Shimokawa Yoko , Nakakoshi Masamichi , Saito Setsu , Suzuki Hideharu , Yokoyama Yuusaku , Ishigami Akihito , Nishioka Hideo , Tsubuki Masayoshi 
Published: November 2012

AbstractArylquinolinones (IV) are prepared by Knorr cyclization of benzoylacetoanilides (III).
ChemInform Abstract: Facile Synthesis of Imidazole Fused Fluoroquinolones.
Authors: Reddy G. Venkat , Shekhar A. Chandra , Kumar A. Ravi , Sathaiah G. , Narsaiah B. , Rao P. Shanthan 
Published: November 2012

AbstractNone of the prepared compounds shows promising antibacterial activity as compared to ciprofloxacin.
ChemInform Abstract: Iridium‐Catalyzed [2 + 2 + 2] Cycloaddition of α,ω‐Diynes with Nitriles.
Authors: Onodera Gen , Shimizu Yoshihisa , Kimura Jun‐na , Kobayashi Junya , Ebihara Yukiko , Kondo Kei , Sakata Ken , Takeuchi Ryo 
Published: November 2012

AbstractA simple catalyst system, obtained by mixing of Ir2Cl2(cod)2 with diphosphine ligands in situ, allows for efficient preparation of pyridine derivatives from nitriles and alkynes.
ChemInform Abstract: Design, Synthesis and Biological Activity Evaluation of 2‐Mercapto‐4(3H)‐quinazolinone Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B.
Authors: Li Hui , Wang Jin‐Ping , Yang Fan , Liu Ting , Qiu Wen‐Wei , Li Jing‐Ya , Li Jia , Tang Jie 
Published: November 2012

AbstractThe title derivatives are obtained by reaction of aminobenzoic acid with formamide/isothiocyanate or by reaction of 4‐substituted aminobenzoic acid derivatives (I) with phenyl isothiocyanate (II), followed by further derivatization.
ChemInform Abstract: Lewis Acid Catalyzed Synthesis of 1‐Aryl‐1,2‐dihydro‐naphtho[1,2‐e][1,3]oxazin‐3‐ones under Solvent Free Conditions: A Mechanistic Approach.
Authors: Sharma Mukul , Manohar Sunny , Rawat Diwan S. 
Published: November 2012

AbstractThe title compounds (IV) are obtained in a Lewis acid catalyzed highly efficient one‐pot three‐component condensation of β‐naphthol (I), urea (II), and various aromatic aldehydes (III) at high temperature.
ChemInform Abstract: Highly Efficient Asymmetric Synthesis of Enantiopure Dihydro‐1,2‐oxazines: Dual‐Organocatalyst‐Promoted Asymmetric Cascade Reaction.
Authors: Lin Hua , Tan Yu , Sun Xing‐Wen , Lin Guo‐Qiang 
Published: November 2012

AbstractThe oxazine products can be converted into optically active 1,4‐amino alcohols.
ChemInform Abstract: A One‐Pot—Three‐Step Route to Triazolotriazepinoindazolones from Oxazolino‐2H‐indazoles.
Authors: Conrad Wayne E. , Rodriguez Kevin X. , Nguyen Huy H. , Fettinger James C. , Haddadin Makhluf J. , Kurth Mark J. 
Published: November 2012

AbstractSequential treatment of oxazolinoindazoles with propargyl bromides and NaN3 allows an efficient access to a number of target compounds.
ChemInform Abstract: Wittig Homologation of 2‐(Chloromethyl)‐2H‐chromen‐2‐ol Derivatives: A New Facile Synthesis of Substituted 2,3‐Dihydrobenzoxepine‐4‐carboxylates.
Authors: Raju Bhimapaka China , Saidachary Gannerla , Kumar Jaladi Ashok 
Published: November 2012

AbstractThe title compounds are synthesized by Wittig reaction of chromenol derivatives (I) and (VIII) with commercially available phosphoranes (II).
ChemInform Abstract: Oxidative Condensations to Form Benzimidazole‐Substituted Potassium Organotrifluoroborates.
Authors: Molander Gary A. , Ajayi Kehinde 
Published: November 2012

AbstractThe method is applied to the synthesis of 2‐biaryl‐substituted benzimidazoles by combination of the oxidative condensation step with the Suzuki—Miyaura cross‐coupling reaction.
ChemInform Abstract: Green Synthesis and Bioactivity of 2‐Amino‐4H‐chromen‐4‐yl‐phosphonates.
Authors: Rajasekhar Mekala , Rao Kunda Uma Maheswara , Sundar Chereddy Syama , Reddy Nemallapudi Bakthavatchala , Nayak Sandip Kumar , Reddy Cirandur Suresh 
Published: November 2012

AbstractA new, simple and efficient green synthesis of the title chromenylphosphonates (IV) (12 examples) using a multicomponent reaction is developed.
ChemInform Abstract: An Efficient Synthesis of Enol Phosphates via Organic Base‐Promoted Addition of Phosphites to 4‐Oxo‐enoates.
Authors: Zhu Xiao‐Yu , Chen Jia‐Rong , Lu Liang‐Qiu , Xiao Wen‐Jing 
Published: November 2012

AbstractA practical, mild, and convenient protocol for the synthesis of the title compounds is described by using a simple and cheap catalyst.
ChemInform Abstract: Synthesis of a Stable 1,2‐Bis(ferrocenyl)diphosphene.
Authors: Sasamori Takahiro , Sakagami Michiyasu , Niwa Masatoshi , Sakai Heisuke , Furukawa Yukio , Tokitoh Norihiro 
Published: November 2012

AbstractThe synthesis and characterization of the title compound (III), wherein a P=P π‐bond connects two bulky ferrocenyl units is reported.
ChemInform Abstract: Synthesis and in vitro Antitumor Activity of 1,3,4‐Oxadiazole Derivatives Based on Benzisoselenazolone.
Authors: Luo Zhen‐Hua , He Shuang‐Yan , Chen Bao‐Quan , Shi Yan‐Ping , Liu Yu‐Ming , Li Cai‐Wen , Wang Qiu‐Sheng 
Published: November 2012

AbstractThe title compounds (V) are screened for their in vitro antiproliferative activities against three different human cancer cell lines.
ChemInform Abstract: A New Synthetic Strategy for Catechin‐Class Polyphenols: Concise Synthesis of (‐)‐Epicatechin and Its 3‐O‐Gallate.
Authors: Stadlbauer Sven , Ohmori Ken , Hattori Fumihiko , Suzuki Keisuke 
Published: November 2012

AbstractKey steps of the described sequence are the assembly of lithiated fluorobenzene which functions as A‐ring surrogate, and the enantiopure epoxide (II) followed by pyran annulation.
ChemInform Abstract: Soft X‐Ray Imaging and Spectromicroscopy: New Insights in Chemical State and Morphology of the Key Components in Operating Fuel‐Cells
Authors: Bozzini Benedetto , Abyaneh Majid Kazemian , Amati Matteo , Gianoncelli Alessandra , Gregoratti Luca , Kaulich Burkhard , Kiskinova Maya 
Published: November 2012

AbstractReview: 74 refs.
Iterative estimation of MRI sensitivity maps and image based on sense reconstruction method (isense)
Authors: Majumdar Angshul , Ward Rabab K. 
Published: November 2012

AbstractSENSitivity Encoding (SENSE) is a parallel MR image reconstruction technique that yields optimal results when the sensitivity maps are accurately known. Unfortunately, in practical scenarios, obtaining accurate estimates of the sensitivity maps is not possible. In this work, we propose a technique that iteratively reconstructs the image and refines the sensitivity maps (from initial estimates). Our technique is named iSENSE (iterative SENSE). Our proposed technique exploits the sparsity of the MR image in some transform domains or the rank deficiency characteristic of the matrix representing the MRI image; the former leads to a compressed sensing‐based reconstruction method, whereas the latter leads to an image reconstruction method that minimizes the nuclear norm (NN) of the image matrix. The sensitivity maps are assumed to be rank‐deficient matrices, and thus the refinement of the sensitivity maps is achieved via the NN minimization. To evaluate the performance of the proposed method, we have carried out the experiments on real and one simulated datasets. We have compared our method with three state‐of‐the‐art image domain methods—SparSENSE (Sparse SENSE), NNSENSE (NN Regularized SENSE), and JSENSE (Joint SENSE reconstruction)—and one widely used frequency domain method—GRAPPA (Generalized Autocalibrating Partially Parallel Acquisition). Our method yields the best reconstruction results both in quantitative (normalized mean‐squared error) and qualitative (visual inspection of reconstructed and difference images) evaluation. © 2012 Wiley Periodicals, Inc. Concepts Magn Reson Part A 40A: 269–280, 2012.
Revealing the Subtle Interplay of Thermal and Quantum Fluctuation Effects on Contact Ion Pairing in Microsolvated HCl
Authors: Walewski Łukasz , Forbert Harald , Marx Dominik 
Published: November 2012

AbstractThe combined effect of thermal fluctuations and quantum mechanical motion on the HCl(H2O)4 cluster is studied at different temperatures. Two conformations of this cluster are investigated: the ringlike structure that involves an undissociated HCl molecule (UD) and the contact ion pair (CIP), which involves the dissociated acid, Cl−, and H3O+. The UD structure is affected by thermal and quantum fluctuations in a similar way. The hydrogen‐bond network is destabilized, and this results in ring expansion and proton orientational rearrangements, though the thermal excitation prevails over the quantum effects at high temperature, while the zero‐point motion dominates in the low‐temperature regime, as expected. In contrast, the thermal and quantum fluctuations exert competing effects on the CIP structure. At high temperature one of the hydrogen bonds accepted by Cl− breaks, and this results in undercoordination of the Cl site, which leads to proton transfer along the fluxional Cl−⋅⋅⋅H3O+ hydrogen bond and formation of molecular HCl. Thus, thermal fluctuations counteract acid dissociation and thus ion‐pair formation. At low temperature however, the decreasing thermal excitations facilitate recovery of the full hydrogen‐bond network, which pushes the proton away from the Cl site and thus leads to acid dissociation, which characterizes the equilibrium structure. On the other hand, quantum mechanical fluctuations, which destabilize the hydrogen bonds supporting the Cl− ion and pull the proton back towards the undissociated limit, become of overriding importance in the low‐temperature limit. As a result, the subtle balance between the two trends enables temperature‐dependent “low‐barrier hydrogen bonding” and establishes a centered hydrogen bond, H2O⋅⋅⋅H+⋅⋅⋅Cl−, at intermediate temperatures.
Cytologic findings of acute leukemia in bronchoalveolar lavage fluid
Authors: O'Leary Michelle , Cantley Richard L. , Kluskens Larry , Gattuso Paolo 
Published: November 2012

AbstractBronchoalveolar lavage (BAL) is often performed in patients with acute leukemia developed with respiratory failure or pulmonary infiltrates. Patients usually undergo BAL to rule out infection. Occasionally, however, leukemic infiltrate may be detected. We present a series of 11 cases in which the diagnosis of leukemia was made on the BAL material. We retrospectively reviewed all BAL samples from January 1, 2006 to December 31, 2008. There were a total of 1,130 cases, of which 139 showed malignant cytology, including 10 with leukemia. Sixteen samples were unsatisfactory and 904 were benign, of which 32 had identifiable microorganisms. In additional to the 10 leukemia cases identified, two more were reviewed after the search criteria. The 12 patients (seven men, five women) ranged from 22 to 75 years old. All patients had previously biopsy‐proven leukemia [two acute myelomonocytic leukemia, two acute promyelocytic leukemia, two acute myeloid leukemia (AML) with inv16, two therapy‐related AML, one acute monocytic leukemia, one chronic myeloid leukemia in blast face, one AML with maturation, one myelodysplastic syndrome with excess blasts, and one large granular leukemia]. Four had a prior diagnosis of myelodysplastic syndrome. The time from initial diagnosis of leukemia to BAL ranged from 1 to 233 days, with 8 of 10 occurring within 8 days of diagnosis. Symptoms that prompted BAL included shortness of breath/hypoxia (8), fever (3), chest pain (2), and cough (2). Chest X‐rays in all cases revealed opacities or consolidations mimicking an inflammatory process. Seven patients subsequently died, while three were alive, and, in remission, and two were lost to follow‐up. The presence of a leukemic infiltrate can mimic infection. BAL is a relatively safe and useful diagnostic tool in this setting for differentiating a leukemic infiltrate from an infection/inflammatory infiltrate. The prognosis of patients with lung involvement of acute leukemia is poor. Diagn. Cytopathol. 2013. © 2012 Wiley Periodicals, Inc.
Gas Adsorption Properties and Selectivity in CuII/Adeninato/Carboxylato Metal–Biomolecule Frameworks
Authors: Pérez‐Yáñez Sonia , Beobide Garikoitz , Castillo Oscar , Fischer Michael , Hoffmann Frank , Fröba Michael , Cepeda Javier , Luque Antonio 
Published: November 2012

AbstractHerein we report the analysis of the porosity of a family of MBioFs with formula [Cu2(μ3‐ade)2(μ‐OOCCH3)2]n (compound 1), [Cu2(μ3‐ade)2(μ‐OOCCH2CH3)2]n (compound 2) and [Cu2(μ3‐ade)2(μ‐OOC(CH2)2CH3)2]n (compound 3) [ade = adeninato], by means of the measurements of N2 (77 K), CO2 (273 K) and H2 (77 K) experimental adsorption isotherms. The experimental results for each adsorptive species show that the uptake capacity decreases on increasing the length of the aliphatic chain of the carboxylato ligand. Although, in general, all compounds show a moderate experimental uptake capacity, the amount of CO2 adsorbed in compound 1 exceeds the values reported for many other well‐known MOFs, which is related to the presence of the Watson–Crick face in the pore wall. The experimental data of all compounds is discussed on the basis of simulated isotherms computed from grand canonical Monte Carlo (GCMC) calculations. To assess the suitability of pores decorated by the Watson–Crick faces for the selective capture of CO2 and CO, the selectivity towards CO2/H2 and CO/H2 gas mixtures was analysed by computing the Henry constants and the binary adsorption isotherms. The results show that the selectivity towards CO2 and CO can be tuned by the carboxylato ligand, increasing its value with increasing length of the aliphatic chain. These selectivity values are relatively high in all compounds, especially for compound 3 in which the pore narrowing promoted by the lengthening of the aliphatic chain favours a preferential adsorption of CO2 and CO, leading to one of the highest values computed for MOFs to date. Moreover, the high affinity towards CO2 and CO, and the marked lowering of the selectivity with increasing pressure observed in compound 3 is explained on the basis of the analysis of the potential energy maps obtained by the simulations, which reveals two different adsorption sites.
Electrocatalytic Oxidation and Determination of Hydrazine at an AuCu Nanoparticles – Graphene – Ionic Liquid Composite Film Coated Glassy Carbon Electrode
Authors: Shang Lei , Zhao Faqiong , Zeng Baizhao 
Published: November 2012

AbstractGold‐copper alloy nanoparticles (AuCu NPs) were electrodeposited on a graphene – ionic liquid composite film (EGN‐IL). The AuCu NPs showed high electrocatalysis to the oxidation of hydrazine with a catalytic reaction rate constant of about 5.0×104 mol/Ls. In phosphate buffer solutions (pH 6.8) the oxidation current of hydrazine at 0.15 V (vs. SCE) at the resulting electrode (AuCuEGN‐IL/GCE) was linear to its concentration in the range of 0.2–110 µM with a sensitivity of 56.7 µA/mM, and the detection limit was 0.1 µM (S/N=3). The electrode was successfully applied to the determination of waste water.
The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle‐associated immune complexes
Authors: Cloutier Nathalie , Tan Sisareuth , Boudreau Luc H. , Cramb Catriona , Subbaiah Roopashree , Lahey Lauren , Albert Alexandra , Shnayder Ruslan , Gobezie Reuben , Nigrovic Peter A. , Farndale Richard W. , Robinson William H. , Brisson Alain , Lee David M. , Boilard Eric 
Published: November 2012

AbstractImmunoglobulins, antigens and complement can assemble to form immune complexes (IC). ICs can be detrimental as they propagate inflammation in autoimmune diseases. Like ICs, submicron extracellular vesicles termed microparticles (MP) are present in the synovial fluid from patients affected with autoimmune arthritis. We examined MPs in rheumatoid arthritis (RA) using high sensitivity flow cytometry and electron microscopy. We find that the MPs in RA synovial fluid are highly heterogeneous in size. The observed larger MPs were in fact MP‐containing ICs (mpICs) and account for the majority of the detectable ICs. These mpICs frequently express the integrin CD41, consistent with platelet origin. Despite expression of the Fc receptor FcγRIIa by platelet‐derived MPs, we find that the mpICs form independently of this receptor. Rather, mpICs display autoantigens vimentin and fibrinogen, and recognition of these targets by anti‐citrullinated peptide antibodies contributes to the production of mpICs. Functionally, platelet mpICs are highly pro‐inflammatory, eliciting leukotriene production by neutrophils. Taken together, our data suggest a unique role for platelet MPs as autoantigen‐expressing elements capable of perpetuating formation of inflammatory ICs.
A One‐Pot Organometallic Route from a 4‐Alkenylpyridine to a 4,4‐Spiro‐Linked Ethyl 1,4‐Dihydropyridine‐1‐carboxylate
Authors: Fraenkel Gideon , Chow Albert , Liang Yulan , Song Jinhua , Gallucci Judith 
Published: November 2012

AbstractIn a one‐pot process without isolation of intermediates, (but‐3‐en‐1‐yl)pyridine (13) is treated sequentially with dicyclohexylborane, trimethylaluminium, and ethyl carbonochloridate yielding ethyl 1,4‐dihydro‐4,4‐(tetramethylene)pyridine‐1‐carboxylate (=ethyl 8‐azaspiro[4.5]deca‐6,9‐diene‐8‐carboxylate; 2) in 46% yield based on starting alkenylpyridine 13 (Scheme 5).
Syntheses of Racemic and Scalemic cis‐Chrysanthemic Acid from β,γ‐Unsaturated Cyclohexanol
Authors: Krief Alain , Jeanmart Stéphane , Gondal Humaira Y. , Kremer Adrian 
Published: November 2012

Abstract2,2,5,5‐Tetramethylcyclohexane‐1,3‐dione is a valuable starting‐material precursor of cis‐chrysanthemic acid. The (1S)‐stereoisomer is a precursor of pyrethrin I, the most active natural insecticide from Chrysanthemum cinerariifolium, whereas the (1R)‐stereoisomer is efficiently transformed to deltamethrin, the most active commercially available pyrethroid insecticide. Several intermediates have been identified and used with variable success for that purpose.
Enantioselective Solid‐Phase Peptide Synthesis Using Traceless Chiral Coupling Reagents and Racemic Amino Acids
Authors: Kolesinska Beata , Kasperowicz‐Frankowska Katarzyna , Fraczyk Justyna , Kaminski Zbigniew J. 
Published: November 2012

AbstractThe enantioselective condensing reagent 4,6‐dimethoxy‐1,3,5‐triazine (DMT)/strychnine/BF$\rm{{_{4}^{-}}}$ was obtained by treatment of 2‐chloro‐4,6‐dimethoxy‐1,3,5‐triazine (CDMT) with strychnine tetrafluoroborate. The reagent was useful under typical conditions of solid‐phase peptide synthesis (SPPS) with enantiomerically homogeneous substrates. By SPPS, desired dipeptides were obtained in 84–94% yield using 4 equiv. of racemic Fmoc‐Ala, Fmoc‐Phe, and/or Fmoc‐Tyr for 1 equiv. of Wang resin loaded with Gly, Ala, Leu, Phe, Glu(tBu), and/or Pro, respectively. For all three Fmoc‐protected amino acids, the configuration of the enantiomer preferred under SPPS conditions was independent of the structure of the acylated component and identical to that established in condensations proceeding in solution. In all cases, the enantiomer ratios L/D (er) were in a similar range, and varied from 9 : 92 to 2 : 98 for alanine, and from 90 : 10 to 100 : 0 for aromatic amino acids. The synthesis of Ac‐L‐Lys(Ac)‐D‐Ala‐D‐Ala‐OH from racemic Fmoc‐Ala gave an L/D ratio of 10 : 90 for the esterification of Wang resin, and 0 : 100 for the formation of peptide bonds.
Microwave‐Assisted Synthesis of β‐Lactams and Cyclo‐β‐dipeptides
Authors: Hernández‐Vázquez Luis G. , Leyva Marco A. , Metta‐Magaña Alejandro J. , Escalante Jaime 
Published: November 2012

AbstractDifferent cyclo‐β‐dipeptides were prepared from corresponding N‐substituted β‐alanine derivatives under mild conditions using PhPOCl2 as activating agent in benzene and Et3N as base. To evaluate β3‐substituent influence, the amino acids 7–26 were synthesized, and a β‐lactam formation reaction was carried out instead of cyclo‐β‐dipeptide formation. The crystal structures of three derivatives of cyclo‐β‐peptides and one β‐lactam are presented.
Catalytic Enantioselective Synthesis of a 3‐Aryl‐3‐benzyloxindole (=3‐Aryl‐3‐benzyl‐1,3‐dihydro‐2H‐indol‐2‐one) Exhibiting Antitumor Activity
Authors: Katayev Dmitry , Kündig E. Peter 
Published: November 2012

AbstractA palladium‐catalyzed intramolecular α‐arylation of an amide in the presence of a bulky chiral N‐heterocyclic carbene ligand is the key step in the first catalytic synthesis of (3R)‐6‐chloro‐3‐(3‐chlorobenzyl)‐1,3‐dihydro‐3‐(3‐methoxyphenyl)‐2H‐indol‐2‐one ((R)‐5). This oxindole, in racemic form, had been shown previously to be an anticancer agent. (R)‐5 was obtained with an overall yield of 45% and with 96% enantioselectivity.