bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whispers of the Cath lab: “Cases we would rather forget”
Authors: Soulaidopoulos Stergios , Vlachakis Panayotis K. , Sagris Marios , Dimitroglou Yannis , Tolis Elias , Theofilis Panagiotis , Aznouridis Konstantinos , Dimitriadis Kyriakos , Drakopoulou Maria , Lozos Vasileios , Toutouzas Konstantinos , Aggeli Constantina , Tsioufis Costas 
Published: July 2024

AbstractIn the dynamic field of interventional cardiology, significant strides have been made in reducing periprocedural complications. Echocardiography, particularly transesophageal echocardiography, plays a key role in ensuring the safety and success of structural heart interventions. Its real‐time imaging capabilities allow for precise monitoring of device positioning, deployment, and procedural outcomes. By adhering to established imaging protocols and acquiring standard imaging planes, periprocedural echocardiography has become an essential tool for the successful performance of many structural heart interventions. In this manuscript, we present a series of unusual yet significant complications that we encountered during structural interventional procedures in our catheter laboratory. These complications, detected through echocardiography, underscore the critical role of imaging guidance in recognizing, and addressing unforeseen challenges, such as device malposition, thrombus formation in cardiac chambers during structural heart interventions, and cardiac tamponade during transcatheter mitral valve procedures. Through these cases, we highlight the effectiveness of transesophageal echocardiography in promptly identifying complications, allowing for timely intervention and resolution.
An efficient one‐pot, three‐component synthesis of novel [1,2,4]triazolo [4′,3′:1,5][1,2,4]triazolo[3,4‐b][1,3,4]thiadiazine derivatives and their molecular docking studies
Authors: Jilloju Parameshwara Chary , Shyam Perugu , Aravind Seema , Vedula Rajeswar Rao 
Published: July 2024

AbstractA series of novel [1,2,4]triazolo[4′,3′:1,5][1,2,4]triazolo[3,4‐b][1,3,4]thiadiazines (4a‐p) were synthesized from the reaction of 4‐amino‐5‐hydrazinyl‐4H‐1,2,4‐triazole‐3‐thiol (1) with different bromoethanones (2a‐p) and substituted benzoic acids (3) via a one‐pot, three‐component reaction with good to excellent yields. The new fused tri‐cyclic system was achieved without using a catalyst and metal by cyclo‐condensation reaction through a one‐pot approach. The structures of newly synthesized molecules were confirmed by using IR, 1H‐NMR, 13C‐NMR, Mass spectral, and analytical data. Molecular docking studies were carried out for the newly synthesized compounds against human cancer receptors (2TKB) with good results.
Long‐term cardiovascular outcomes and mortality with enzyme replacement therapy in patients with mucopolysaccharidosis type II
Authors: Kwak Ji Hee , Choi Yong Jun , Kim Sinae , Yang Aram 
Published: July 2024

AbstractMucopolysaccharidosis type II (MPS II) is a rare multisystemic lysosomal disorder in which cardiac issues can lead to serious dysfunction and an increased risk of fatal cardiac failure. However, studies on major adverse cardiac event (MACE) outcomes in MPS II are lacking. This study evaluated the cardiovascular outcomes and impact of enzyme replacement therapy (ERT) in patients with MPS II in South Korea. In this national cohort study, utilizing data from the National Health Insurance Database, we evaluated 127 patients with MPS II over a 14‐year period to investigate the effects of ERT on MACE and all‐cause mortality. We tracked MACE incidence, defined by hospitalizations for cardiovascular events, from diagnosis and adjusted the hazard ratios for MACE using Cox modeling. Over an average follow‐up period of 7.3 years, we identified 16 cases of MACE among patients (17.35 per 1000 person‐years; 95% confidence interval, 10.74–26.83). Patients receiving ERT exhibited a significantly lower incidence of MACE than untreated patients, with cumulative incidences showing a marked difference of 8.3 years. Notably, initiating ERT at earlier stages post‐diagnosis was associated with improved outcomes, underscoring the importance of timely treatment. The key risk factors for MACE included specific arrhythmias, a history of invasive procedures, and depression. Early ERT significantly reduced MACE risk and increased survival in patients with MPS II. This underscores the importance of prompt treatment initiation and comprehensive care to address key risk factors and advocates for an expanded therapeutic strategy to enhance MPS II outcomes.
High b‐Value and Ultra‐High b‐Value Diffusion Weighted MRI in Stroke
Authors: Jiang Rifeng , Wang ZhenXiong , Liu Jun , Li Ting , Lv YanChun , Xie Chuanmiao , Su Changliang 
Published: July 2024

PurposeTo explore the application value of high‐b‐value and ultra‐high b‐value DWI in noninvasive evaluation of ischemic infarctions.Study TypeProspective.SubjectsSixty‐four patients with clinically diagnosed ischemic lesions based on symptoms and DWI.Field Strength/Sequence3.0 T/T2‐weighted fast spin‐echo, fluid‐attenuated inversion recovery, pre‐contrast T1‐weighted magnetization prepared rapid gradient echo sequence, multi‐b‐value trace DWI and q‐space sampling sequences.AssessmentLesions were segmented on standard b‐value DWI (SB‐DWI, 1000 s/mm2), high b‐value DWI (HB‐DWI, 4000 s/mm2) and ultra‐high b‐value DWI (UB‐DWI, 10,000 s/mm2), and cumulative segmented areas were the final abnormality volumes. Normal white matter (WM) areas were obtained after binarization of segmented brain. In 47 patients, fractional anisotropy (FA) and apparent diffusion coefficients (ADCs) at b values of 1000, 4000, and 10,000 s/mm2 were extracted from symmetrical WM masks and lesion masks of contralateral WM (CWM) and lesion‐side WM (LWM).Statistical TestsWilcoxon matched‐pairs signed‐rank test and Pearson correlation analysis. Two‐tailed P‐values <0.05 were considered statistically significant.ResultsVarious signals of HB‐/UB‐DWI (hypo‐, iso‐ or hyper‐intensity) were observed in strokes compared with SB‐DWI, and some areas with iso‐intensity of SB‐DWI manifested with hyper‐intensity on HB‐/UB‐DWI. Abnormality volumes from SB‐DWI were significantly smaller than those from HB‐DWI and UB‐DWI (10.32 ± 16.45 cm3, vs. 12.25 ± 19.71 cm3 and 11.83 ± 19.41 cm3), while no significant difference exist in volume between HB‐DWI and UB‐DWI (P = 0.32). In CWM, FA significantly correlated with ADC4000 and ADC10,000 (maximum r = −0.51 and −0.64), but did not significantly correlate with ADC1000 (maximum r = −0.20, P = 0.17). ADC1000 or ADC4000 of LWM not significant correlated with FA of CWM (maximum r = −0.28, P = 0.06), while ADC10,000 of LWM significantly correlated with FA of CWM (maximum r = −0.46).Data ConclusionHB‐ and UB‐DWI have potential to be supplementary tools for the noninvasive evaluation of stroke lesions in clinics.Evidence Level2Technical EfficacyStage 2
Urban Heat Island Trends in the Middle East and North Africa: A statistical approach
Authors: Tzyrkalli Anna , Economou Theo , Lazoglou Georgia , Constantinidou Katiana , Hadjinicolaou Panos , Lelieveld Jos 
Published: July 2024

AbstractThe urban heat island (UHI) effect denotes that temperatures in urban areas are often higher compared to the rural background. This human‐induced phenomenon can exacerbate heat stress and adverse health impacts, adding to ongoing global warming. To examine the intensity and variability of the UHI effect, we used 40 years () of observational data (daily maximum and minimum temperature) from the Global Summary of the Day (GSOD), comprising about 1000 stations of varying temporal extent, spanning the Middle East and North Africa (MENA). The MENA is characterised by hot and dry summers and warms faster than other inhabited regions worldwide. The challenge in using data with diverse spatial and temporal extents is accounting for heterogeneities between each station comprising an urban–rural pair. One has to allow for differences in the distance between the pairs and, elevation, spatial–temporal changes in urbanisation as well as the distance from the coast. A new method is proposed, based on flexible statistical methods (Generalized Additive Models or GAMs), to quantify the temporal trend in the UHI effect while allowing for the aforementioned characteristics using regression splines of appropriately defined variables. A composition of high‐resolution satellite geospatial information, related to urbanisation properties and population data was utilised from the Global Human Settlement Layer database (GHSL‐SMOD), to characterise the stations in terms of their urbanisation type. These data were also used to quantify temporal changes in the extent of urbanisation relative to the surrounding areas. Results indicate consistent upward trends of the UHI effect in the MENA (up to °C), particularly at night (daily minimum temperature) during all seasons.
A new approach for discriminating spatially acquired SERS spectra using antiretroviral drug emtricitabine as a test sample
Authors: Hrncirova Jana , Butler Marguerite R. , Clark Meredith R. , Doncel Gustavo F. , Cooper John B. 
Published: July 2024

AbstractIn this study, an antiretroviral drug emtricitabine (also known as FTC or Emtriva) was detected and quantified down to 40 ng/ml by using surface‐enhanced Raman spectroscopy (SERS). Its aqueous standards were tested with two types of silver nanoparticles (colloidal and dendritic) using a specially developed aluminum well plate. The SERS spectra were acquired using a Raman scanning device with 30‐μm spatial resolution. The spectral data were analyzed using a new approach for the discrimination of the spatially acquired spectra based on the Quality index (Qi). After the Qi is calculated, the spectral data are sorted based on the Qi. This is followed by selecting only the spectra with a high Qi index and comparing the average of all the spatially acquired spectra. This results in an improvement in the spectral signal‐to‐noise and higher analytical sensitivity of the built calibration curves.
Exploring the extraction, functional properties, and industrial applications of papain from Carica papaya
Authors: Choudhary Rajni , Kaushik Ravinder , Chawla Prince , Manna Suvendu 
Published: July 2024

AbstractPapain a protease enzyme naturally present in the Carica papaya has gained significant interest across several industries due to its unique properties and versatility. The unique structure of papain imparts the functionality that assists in elucidating how papain enzyme works and making it beneficial for a variety of purposes. This review highlights recent advancements in papain extraction techniques to enhance production efficiency to meet market demand. The extraction of papain from the Carica papaya plant offers various advantages such as cost‐effectiveness, biodegradability, safety, and the ability to withstand a wide range of pH and temperature conditions. Key findings reveal that non‐conventional papain extraction techniques offer significant advantages in terms of efficiency, product quality, and environmental sustainability. Furthermore, papain treatment enhances the value of final products due to its anti‐bacterial, anti‐oxidant, and anti‐obesity properties. The ability of papain to hydrolyze a wide range of proteins across various conditions makes it a suitable protease enzyme. While the study emphasizes the advantages of papain, the study also acknowledges limitations such as the continuous research and development to optimize extraction processes which will help unlock papain's potential and meet the growing demand. © 2024 Society of Chemical Industry.
The response of Midknight Valencia oranges to ethephon degreening varies in the turning and regreening stages
Authors: Li Huimin , Ai Yeru , Zeng Kaifang , Deng Lili 
Published: July 2024

AbstractBACKGROUNDLate‐ripening citrus plays an important role in the stability of the global citrus industry. However, the regreening phenomenon in Valencia oranges impacts the peel color and commercial value. Ethylene degreening is an effective technique to improve the color of citrus fruits, but this effect may be delayed in regreened oranges. To better clarify this phenomenon, plastid morphology, pigment and phytohormone content in ethephon‐degreened Midknight Valencia oranges harvested in different stages were evaluated.RESULTSResults showed that in fruits harvested at the turning stage, ethephon degreening treatment induced a chloroplast‐to‐chromoplast transition, and chlorophyll degradation and carotenoid accumulation were accelerated. Conversely, in fruits harvested at the regreening stage, the changes in plastid morphology were minimal, with delayed changes in chlorophyll and carotenoids. Genes related to ethylene biosynthesis and signaling pathways supported these responses. Variations in endogenous auxin, jasmonic acid, abscisic acid and gibberellins could partially explain this phenomenon.CONCLUSIONThe response of Midknight Valencia oranges to ethephon degreening was delayed in the regreening stage, possibly due to the dynamic variations in endogenous phytohormones. © 2024 Society of Chemical Industry.
Environmental cognition and peer attitudes: Influencing tourists' waste‐sorting behavior in rural tourism destinations
Authors: Zhong Daojun , Gou Wanru , Zhou Xiaoying , Han Chao , Chen Jin 
Published: July 2024

AbstractThis research assesses the determinants impacting the behavior in rural tourism destinations regarding tourists' waste sorting (WSB), emphasizing the significance of social norms and peer networks. Survey data was gathered from 955 participants in rural tourist destinations across Henan, Shandong, and Anhui provinces. The empirical findings illuminate several crucial aspects: (1) social norms and peer networks wield a positive, catalyzing influence on tourists' WSB in rural tourism settings. (2) Peer attitudes shape tourists' WSB, and environmental cognition plays a pivotal mediating role. The novelty of this study lies in its comprehensive exploration of the influence of social norms and peer networks on tourists' WSB in rural tourism destinations, highlighting the unique interplay of cognitive, behavioral, and attitudinal factors in this context. (3) Cognitive norms and behavioral norms have a more significant impact on female tourists. (4) For frequent travel groups, social norms affect waste‐sorting behavior less.
Medical tourism destination image: Scale development
Authors: Alp Gamze , Yılmaz Yıldırım 
Published: July 2024

AbstractIn response to heightened competition among destinations vying for medical tourists, these destinations have prioritized improving their image. Although several scales exist to assess destination images, there is a scarcity of scales specifically tailored to measure the image of medical tourism destinations. To address this gap, a thorough scale development process was employed, resulting in the creation of a second‐order model known as the medical tourism destination image scale. This scale explores four dimensions: quality of doctors and hospitals, ease of travel and safety, variety of treatment, and communication. The findings underscore the significant potential for marketers and policymakers to enhance the attractiveness of medical tourism destinations.
Quantitative Analysis of Right Atrial Functions by 2D‐Speckle Tracking Echocardiography During Healthy Pregnancy
Authors: Guler Yeliz , Karagoz Ali , Inan Duygu , Sonsoz Mehmet R. , Bilen Mehmet N. , Guler Ahmet , Kirma Cevat 
Published: July 2024

BackgroundThe role of speckle tracking in the assessment of right atrial (RA) deformation parameters has not been investigated yet. The purpose of this article is to establish the effects of normal pregnancy on RA mechanical changes obtained by 2‐dimensional speckle‐tracking echocardiography.MethodologyA total of 49 healthy pregnant women were included in the study. All participants were followed for each trimester and postpartum period, encompassing standard assessments of both RA and ventricular functions, as well as measurements of RA global peak atrial longitudinal strain (RA‐Global‐PALS) and RA global peak atrial contraction strain (RA‐Global‐PACS). Additionally, the RA segments were individually evaluated with respect to strain parameters.ResultsDuring pregnancy, the increased volume load resulted in elevated RA reservoir function, as indicated by RA‐Global‐PALS, and increased contraction parameter, as indicated by RA‐Global‐PACS. These changes were within physiological limits and reversible. Segmental analysis of the right atrium showed similar findings for regional PACS and PALS parameters.ConclusionIn this study, we established normal RA deformation parameters for healthy pregnancies. These data will aid in discerning various measures of RA phasic function in cardiovascular and systemic conditions among normal pregnant women. Moreover, they may offer insights into potential cardiac pathologies that may arise during the pregnancy.
The addition of mesenchymal stem cells in a bioabsorbable scaffold does not enhance tendon healing after a repair of rotator cuff tear
Authors: Christogiannis Ioannis F. , Mastrokalos Dimitrios S. , Papagelopoulos Panayiotis J. , Lakiotaki Eleftheria , Karatrasoglou Eleni , Bami Myrto , Milonaki Mandy , Koulalis Dimitrios 
Published: July 2024

AbstractPurposeThe purpose of the study is to evaluate the healing potential of a full‐thickness tendon defect in the rotator cuff of rabbits using a bioabsorbable scaffold impregnated with bone marrow–mesenchymal stem cells (BM‐MSCs) or rotator cuff‐derived mesenchymal stem cells (RC‐MSCs).MethodsSixteen adult rabbits were subjected to a full‐thickness rotator cuff deficit. Rabbits were randomly assigned to four groups of four animals. In Group 0 (control), the deficit was left untreated. In Group 1, the deficit was treated with a single synthetic scaffold alone. In Group 2, the deficit was treated with the previous scaffold loaded with allogeneic BM‐MSCs. In Group 3, the deficit was treated with the previous scaffold loaded with allogenic RC‐MSCs. After animal sacrifice, tissue samples were subjected to histological and immunohistochemical analysis.ResultsGroup 1 showed the highest mean tendon maturing score (15.3 ± 0.9) postoperatively, being significantly higher, in comparison to groups 0, 2 and 3 (p = 0.01, 0.02 and 0.01, respectively). Group 1 showed the highest mean collagen I/collagen III ratio (1.4 ± 0.8) postoperatively but without any statistical significance.ConclusionsThe utilization of MSCs in rotator cuff repair in a rabbit model has not been associated with an enhancement in tendon healing in 16 weeks postoperatively, in comparison to controls and bioabsorbable scaffolds. The addition of MSCs does not result in better rotator cuff healing.Level of EvidenceNot applicable. This is an animal study.
Effect of a dense inflow on the stratification of a steep‐sided lake
Authors: Pieters Roger , Lawrence Gregory A. , Leung Albert , Crusius John , Pedersen Thomas 
Published: July 2024

AbstractWe detail the effect of a small stream of dense inflow that significantly altered the stratification and water quality in a constructed water body in northern British Columbia, Canada. As the dense inflow passed through the epilimnion of the steep‐sided lake, it entrained relatively large quantities of water. The resulting mixture of dense inflow and entrained epilimnetic water sank to the bottom of the lake. The removal of water from the epilimnion due to entrainment reduced the epilimnetic thickness. This opposes the normal process of epilimnetic deepening due to wind and convective cooling. The flux of fluid entrained into the dense inflow was calculated to be between 4 and 14 times the inflow, depending primarily on the thickness of the epilimnion. The entrainment had four major effects: (1) it reduced the residence time of the epilimnion from half a year to less than a month; (2) it removed the freshwater cap that resulted from spring ice melt; (3) it enabled fall turnover, which further enhanced deep oxygen content and helped to prevent meromixis from developing in the lake; and (4) it produced a rapid decline in contaminant (i.e., zinc) concentrations in the epilimnion, which received dissolved metals inputs from oxidized sulfide minerals exposed in the subaerial walls of the lake. Given the wide variety of inflows to inland water bodies, some of which are at least seasonally dense, an understanding of the mechanisms detailed here can inform lake management in general, and more specifically, management of water quality in mine‐impacted water bodies.
Investigation on Surface Roughness and Power Consumption for Sustainability Assessment in Hard Turning of HSLA Steel With SPPP‐AlTiSiN–Coated Carbide Tool Under Various Cooling‐Lubrications
Authors: Roy Soumikh , Pradhan Arupam , Padhan Smita , Das Anshuman , Das Sudhansu Ranjan , Dhupal Debabrata 
Published: July 2024

ABSTRACTThe present research analyses the power consumption (P
c) and surface roughness (R
a) in hard turning of high‐strength low‐alloy (HSLA) grade AISI 4140 steel using a recently developed AlTiSiN‐coated carbide tool under different cooling‐lubrication conditions (dry, flooded, nanofluid‐MQL). The nanofluid was prepared by mixing the MWCNT nanoparticles with an eco‐friendly automotive radiator coolant (base fluid). The cooling‐lubrication performance is investigated briefly by comparing the machining responses like machined surface morphology, tool wear, cutting force and temperature. The experiments associated with 46 trials were performed by considering various machining variables, namely cutting speed, nose radius, depth of cut, feed and cooling‐lubrication methods. From the perspective of predictive modelling and multi‐response optimisation, response surface methodology has been employed to minimise power consumption and surface roughness. Thereafter, the predictive modelling and optimisation results are implemented for economic analysis and energy‐saving carbon footprint evaluation. This innovative research also addresses comparative environmental sustainability evaluation in hard turning under different cooling‐lubrication conditions using a life cycle assessment methodology for cleaner and safer production. Results indicate that cutting speed was the most influential item in power consumption enhancement. Furthermore, compared with dry and flooded turning, lower cutting force, reduced cutting temperature, shorter width of flank wear and better surface morphology were obtained under nanofluid‐MQL machining. It has been observed that nanofluid‐MQL machining outperformed sustainability improvement concerning techno‐economically viable societal acceptable and environmental friendliness.
Dual‐Crosslinked Antibacterial Hydrogel for Treatment of Diabetic Foot Ulcers
Authors: Zou Zheng , Zhang Zhen , Gao Yang , Yuan Huixian , Guo Ting , He Chaoliang , Chen Xuesi 
Published: July 2024

AbstractDiabetic foot ulcer has become a heavy burden to the healthcare system with the high and growing incidence of diabetes. Persistent bacterial infections in diabetic wounds can lead to chronic inflammation and delayed wound healing. To address these challenges, a dual‐crosslinked antibacterial hydrogel loaded with anti‐inflammatory compound asiaticoside is developed in this study. The hydrogel demonstrated suitable gelation properties, good biocompatibility, and exceptional antibacterial activity. In a diabetic foot ulcer model on rats, the asiaticoside‐loaded hydrogel can alleviate inflammation, promote angiogenesis, and accelerate wound healing. Therefore, this asiaticoside‐loaded antibacterial hydrogel shows considerable potential for diabetic wound healing.