bluuebunny/crossref_metadata_2025_split huggingface dataset:
James Dean
Authors: Hemmer Kurt 
Published: November 2014

James Dean (b. 1931–d. 1955), along with the actors Montgomery Clift and Marlon Brando, ushered onto the American silver screen a type of acting often called the “Method,” which was inspired by the teachings of the Russian director Constantin Stanislavsky. Although a great deal of debate exists over what the Method actually is, it can generally be described as “reacting” rather than “acting,” in order to create a more naturalistic and internally derived style. To what extent Dean absorbed the Method through classes he took with James Whitmore in California and Lee Strasberg in New York, or whether his style of acting was simply “natural,” is a matter of debate. What is indisputable is that his name and reputation are connected to this technique that had a tremendous influence on the New York stage via the Actors Studio before coming in front of Hollywood cameras. Although Dean starred in only three films—East of Eden (1955), Rebel Without a Cause (1955), and Giant (1956)—he is still considered one of the major influences on contemporary acting with actors from his own generation (Paul Newman, Steve McQueen, and Dennis Hopper) to the next generation (Jack Nicholson, Al Pacino, and Robert De Niro) and the following generation (Sean Penn, River Phoenix, Brad Pitt, Leonardo DiCaprio, and Johnny Depp) being inevitably compared to him. Many biographies, journalism, and documentaries have accumulated over the years since Dean’s death, in forms often exploitive and sensational, dealing with his sexuality and psychology. Much vigorous scholarship on the true worth of his acting skills and his place in the cultural landscape of his time and in the 21st century can still be done. Unlike Clift and Brando, Dean did not spend much time refining his craft on the stage and did much of his initial work on television. What makes Dean unique is his position as a cultural icon, largely the result of his tragic death in a car accident on 30 September 1955. His image is recognized throughout the world as a signifier readily filled by several types of, often contradictory, iconography: teenager, rebel, all-American, cowboy, biker, punk, homosexual, among others. Born in Marion, Indiana, and later raised in Fairmount, Indiana, by his aunt and uncle after his mother died when he was nine, Dean achieved in his short lifetime what he claimed was most important to him—immortality.
Subgroup Differences in Response to 8 Weeks of Ledipasvir/Sofosbuvir for Chronic Hepatitis C
Authors: O'Brien Thomas R. , Lang Kuhs Krystle A. , Pfeiffer Ruth M. 
Published: November 2014

Abstract
Treatment of hepatitis C virus (HCV) infection with ledipasvir/sofosbuvir promises tremendous benefits, but high cost may impede implementation of this regimen. Subgroups with excellent response to 8 weeks of treatment might respond to a shorter course. In ION-3, 423 previously untreated HCV genotype 1-infected patients without cirrhosis had outcome data after receiving ledipasvir/sofosbuvir for 8 weeks. After reanalyzing published ION-3 data, we found that sustained virologic response (SVR) rates varied significantly by gender (P = .002) and rs12979860 genotype (Ptrend = .03), exceeding 98% in women and rs12979860-CC individuals. The very high SVR rates in these subgroups suggest that these factors might be considered in selecting patients to receive 8 weeks of ledipasvir/sofosbuvir and support shorter trials of this regimen in selected patients.
Observations of the bursting activity of the 6.7 GHz methanol maser in G33.641−0.228
Authors: Fujisawa Kenta , Aoki Nozomu , Nagadomi Yoshito , Kimura Saki , Shimomura Tadashi , Takase Genta , Sugiyama Koichiro , Motogi Kazuhito , Niinuma Kotaro , Hirota Tomoya , Yonekura Yoshinori 
Published: November 2014

Abstract
We have observed bursting variability of the 6.7 GHz methanol maser of G33.641−0.228. Five bursts were detected in the observation period of 294 days from 2009 to 2012. The typical burst is a large flux density rise in about one day followed by a slow fall. A non-typical burst observed in 2010 showed a large and rapid flux density enhancement from the stable state, but the rise and fall of the flux density were temporally symmetric and a fast fluctuation continued for 12 days. On average, the bursts occurred once every 59 days, although bursting was not periodic. Since the average power required for causing a burst of order of 1021 J s−1 is far smaller than the luminosity of G33.641−0.228, a very small fraction of the source's power would be sufficient to cause the burst occasionally. The burst can be explained as a solar-flare-like event in which the energy is accumulated in the magnetic field of the circumstellar disk, and is released for a short time. However, the mechanism of the energy release and the dust heating process are still unknown.
On the scope and limitations of baker’s yeast as a model organism for studying human tissue-specific pathways
Authors: Mohammadi Shahin , Saberidokht Baharak , Subramaniam Shankar , Grama Ananth 
Published: November 2014

AbstractBudding yeast, S. cerevisiae, has been used extensively as a model organism for studying cellular processes in evolutionarily distant species, including humans. However, different human tissues, while inheriting a similar genetic code, exhibit distinct anatomical and physiological properties. Specific biochemical processes and associated biomolecules that differentiate various tissues are not completely understood, neither is the extent to which a unicellular organism, such as yeast, can be used to model these processes within each tissue.We propose a novel computational and statistical framework to systematically quantify the suitability of yeast as a model organism for different human tissues. We develop a computational method for dissecting the human interactome into tissue-specific cellular networks. Using these networks, we simultaneously partition the functional space of human genes, and their corresponding pathways, based on their conservation both across species and among different tissues. We study these subspaces in detail, and relate them to the overall similarity of each tissue with yeast.Many complex disorders are driven by a coupling of housekeeping (universally expressed in all tissues) and tissue-selective (expressed only in specific tissues) dysregulated pathways. We show that human-specific subsets of tissue-selective genes are significantly associated with the onset and development of a number of pathologies. Consequently, they provide excellent candidates as drug targets for therapeutic interventions. We also present a novel tool that can be used to assess the suitability of the yeast model for studying tissue-specific physiology and pathophysiology in humans.
Reveel: large-scale population genotyping using low-coverage sequencing data
Authors: Huang Lin , Wang Bo , Chen Ruitang , Bercovici Sivan , Batzoglou Serafim 
Published: November 2014

AbstractPopulation low-coverage whole-genome sequencing is rapidly emerging as a prominent approach for discovering genomic variation and genotyping a cohort. This approach combines substantially lower cost than full-coverage sequencing with whole-genome discovery of low-allele-frequency variants, to an extent that is not possible with array genotyping or exome sequencing. However, a challenging computational problem arises when attempting to discover variants and genotype the entire cohort. Variant discovery and genotyping are relatively straightforward on a single individual that has been sequenced at high coverage, because the inference decomposes into the independent genotyping of each genomic position for which a sufficient number of confidently mapped reads are available. However, in cases where low-coverage population data are given, the joint inference requires leveraging the complex linkage disequilibrium patterns in the cohort to compensate for sparse and missing data in each individual. The potentially massive computation time for such inference, as well as the missing data that confound low-frequency allele discovery, need to be overcome for this approach to become practical. Here, we present Reveel, a novel method for single nucleotide variant calling and genotyping of large cohorts that have been sequenced at low coverage. Reveel introduces a novel technique for leveraging linkage disequilibrium that deviates from previous Markov-based models. We evaluate Reveel’s performance through extensive simulations as well as real data from the 1000 Genomes Project, and show that it achieves higher accuracy in low-frequency allele discovery and substantially lower computation cost than previous state-of-the-art methods.
Preliminary crystallographic analysis of Xyn52B2, a GH52 β-D-xylosidase fromGeobacillus stearothermophilusT6
Authors: Dann Roie , Lansky Shifra , Lavid Noa , Zehavi Arie , Belakhov Valery , Baasov Timor , Dvir Hay , Manjasetty Babu , Belrhali Hassan , Shoham Yuval , Shoham Gil 
Published: November 2014

Geobacillus stearothermophilusT6 is a thermophilic bacterium that possesses an extensive hemicellulolytic system, including over 40 specific genes that are dedicated to this purpose. For the utilization of xylan, the bacterium uses an extracellular xylanase which degrades xylan to decorated xylo-oligomers that are imported into the cell. These oligomers are hydrolyzed by side-chain-cleaving enzymes such as arabinofuranosidases, acetylesterases and a glucuronidase, and finally by an intracellular xylanase and a number of β-xylosidases. One of these β-xylosidases is Xyn52B2, a GH52 enzyme that has already proved to be useful for various glycosynthesis applications. In addition to its demonstrated glycosynthase properties, interest in the structural aspects of Xyn52B2 stems from its special glycoside hydrolase family, GH52, the structures and mechanisms of which are only starting to be resolved. Here, the cloning, overexpression, purification and crystallization of Xyn52B2 are reported. The most suitable crystal form that has been obtained belonged to the orthorhombicP212121space group, with average unit-cell parametersa = 97.7,b= 119.1,c = 242.3 Å. Several X-ray diffraction data sets have been collected from flash-cooled crystals of this form, including the wild-type enzyme (3.70 Å resolution), the E335G catalytic mutant (2.95 Å resolution), a potential mercury derivative (2.15 Å resolution) and a selenomethionine derivative (3.90 Å resolution). These data are currently being used for detailed three-dimensional structure determination of the Xyn52B2 protein.
Stacking the odds: light pollution may shift the balance in an ancient predator–prey arms race
Authors: Minnaar Corneile , Boyles Justin G. , Minnaar Ingrid A. , Sole Catherine L. , McKechnie Andrew E. 
Published: November 2014

Summary

Artificial night lighting threatens to disrupt strongly conserved light‐dependent processes in animals and may have cascading effects on ecosystems as species interactions become altered. Insectivorous bats and their prey have been involved in a nocturnal, co‐evolutionary arms race for millions of years. Lights may interfere with anti‐bat defensive behaviours in moths, and disrupt a complex and globally ubiquitous interaction between bats and insects, ultimately leading to detrimental consequences for ecosystems on a global scale.

We combined experimental and mathematical approaches to determine effects of light pollution on a free‐living bat–insect community. We compared prey selection by Cape serotine bats Neoromicia capensis in naturally unlit and artificially lit conditions using a manipulative field experiment, and developed a probabilistic model based on a suite of prey‐selection factors to explain differences in observed diet.

Moth consumption by N. capensis was low under unlit conditions (mean percentage volume ± SD: 5·91 ± 6·25%), while moth consumption increased sixfold (mean percentage volume ± SD: 35·42 ± 17·90%) under lit conditions despite a decrease in relative moth abundance. Predictive prey‐selection models that included high‐efficacy estimates for eared‐moth defensive behaviour found most support given diet data for bats in unlit conditions. Conversely, models that estimated eared‐moth defensive behaviour as absent or low found more support given diet data for bats in lit conditions. Our models therefore suggest the increase in moth consumption was a result of light‐induced, decreased eared‐moth defensive behaviour.

Policy implications. In the current context of unyielding growth in global light pollution, we predict that specialist moth‐eating bats and eared moths will face ever‐increasing challenges to survival through increased resource competition and predation risk, respectively. Lights should be developed to be less attractive to moths, with the goal of reducing effects on moth behaviour. Unfortunately, market preference for broad‐spectrum lighting and possible effects on other taxa make development of moth‐friendly lighting improbable. Mitigation should therefore focus on the reduction of temporal, spatial and luminance redundancy in outdoor lighting. Restriction of light inside nature reserves and urban greenbelts can help maintain dark refugia for moth‐eating bats and moths, and may become important for their persistence.
Effects of baking conditions on colour, texture and crumb grain characteristics of Chhana Podo
Authors: Kumari Anu , Eljeeva Emerald Franklin Magdaline , Simha Vikram , Pushpadass Heartwin A 
Published: November 2014

Baking, the key step in the preparation of Chhana Podo, involves simultaneous heat and mass transfer that induces physicochemical and structural changes in the product. The effects of baking conditions on colour, texture and crumb grain development in the product were evaluated. The browning index of baked Podo increased from the initial value of 15.7 to 95, 101 and 112, at baking temperatures of 120, 135 and 150 °C, respectively. Browning kinetics followed the logistic model (R2 > 0.98) with an activation energy of 17.81 kJ/mol. In general, crumb grain characteristics such as mean cell area, cell density and cell‐to‐total area ratio increased with increase in baking time and temperature. Textural attributes such as hardness, chewiness and gumminess increased with baking time and temperature while springiness, cohesiveness and resilience increased up to 40 min due to the filling‐up of pores water and liquid by fat and expanding water, but decreased thereafter.
Optimization of a Statistical Algorithm for Objective Comparison of Toolmarks
Authors: Spotts Ryan , Chumbley L. Scott , Ekstrand Laura , Zhang Song , Kreiser James 
Published: November 2014

AbstractDue to historical legal challenges, there is a driving force for the development of objective methods of forensic toolmark identification. This study utilizes an algorithm to separate matching and nonmatching shear cut toolmarks created using fifty sequentially manufactured pliers. Unlike previously analyzed striated screwdriver marks, shear cut marks contain discontinuous groups of striations, posing a more difficult test of algorithm applicability. The algorithm compares correlation between optical 3D toolmark topography data, producing a Wilcoxon rank sum test statistic. Relative magnitude of this metric separates the matching and nonmatching toolmarks. Results show a high degree of statistical separation between matching and nonmatching distributions. Further separation is achieved with optimized input parameters and implementation of a “leash” preventing a previous source of outliers—however complete statistical separation was not achieved. This paper represents further development of objective methods of toolmark identification and further validation of the assumption that toolmarks are identifiably unique.
Oviposition preference and larval performance of Epiphyas postvittana (Lepidoptera: Tortricidae) on Botrytis cinerea (Helotiales: Sclerotiniaceae) infected berries of Vitis vinifera (Vitales: Vitaceae)
Authors: Rizvi Syed Z. M. , Raman Anantanarayanan , Wheatley Warwick M. , Cook Geoffrey 
Published: November 2014

AbstractIn this paper we tested the behavior of gravid Epiphyas postvittana in selecting the most‐appropriate site for oviposition thus benefitting offspring performance. Our hypothesis was built on Jaenike's preference–performance hypothesis (also referred to as the “mother‐knows‐the‐best” hypothesis). To test this, we used the interacting Epiphyas postvittana, its host Vitis vinifera, and the pathogenic microbe Botrytis cinerea system. Populations of E. postvittana and B. cinerea often exist concurrently on V. vinifera in Australasia and their interaction and mutual influence are currently being explored, although the suggestion presently is that the relationship between E. postvittana and B. cinerea is mutualistic. We tested the effect of volatiles from B. cinerea‐infected berries and uninfected (control) berries of V. vinifera on the oviposition behavior of E. postvittana. We also characterized the effects of B. cinerea infection on the berries of V. vinifera on the growth and development of E. postvittana. Contrary to the preference–performance hypothesis, oviposition choices made by gravid E. postvittana did not result in the best offspring survival, development, and performance. The preference for oviposition by E. postvittana was strongly influenced by the olfactory and tactile cues. She laid fewer eggs on B. cinerea‐infected berries compared to uninfected berries of V. vinifera. The larvae of E. postvittana showed no preference to uninfected berries of V. vinifera. The larvae fed on B. cinerea‐infected berries of V. vinifera showing greater survival rate, shorter time to pupation, greater pupal mass, and on becoming adults they laid more numbers of eggs than the larvae that were enabled to feed on uninfected berries. The larvae of E. postvittana transport the conidia of B. cinerea and transmit grey‐mould disease to uninfected berries of V. vinifera.
The Effect of Measurement Subjectivity Classifications on Analysts' Use of Persistence Classifications When Forecasting Earnings Items
Authors: Hewitt Max , Tarca Ann , Yohn Teri Lombardi 
Published: November 2014

AbstractEarnings items are typically classified in financial reports based on their persistence and measurement subjectivity. Archival research examines investors' use of persistence and measurement subjectivity classifications for forecasting and valuation. However, this research typically examines only one of these classifications at a time and ignores the potential interactive implications of an earnings item's persistence and measurement subjectivity classifications. We recruited experienced financial analysts to participate in two experiments that examined the effect of measurement subjectivity classifications on analysts' use of persistence classifications when forecasting earnings items. We find that analysts rely less on an earnings item's persistence classification when measurement subjectivity is high relative to when measurement subjectivity is low. We also find that presentation format affects analysts' use of these two classifications. Specifically, we find that the matrix format (i.e., rows display persistence classifications and columns display measurement subjectivity classifications) facilitates analysts' combined use of persistence and measurement subjectivity classifications relative to the sequential format (i.e., the classifications are displayed separately). These findings suggest that archival research could improve its examination of market participants' use of earnings classifications for forecasting and valuation by recognizing that the implications of an earnings item's persistence classification can vary according to the item's measurement subjectivity classification. By also demonstrating how presentation format affects analysts' use of earnings classifications, our study provides further insights into this fundamental issue in accounting research and standard setting.
Fine‐scale impacts on avian biodiversity due to a despotic species, the bell miner (Manorina melanophrys)
Authors: Leseberg Nicholas P. , Lambert Kathryn T. A. , McDonald Paul G. 
Published: November 2014

AbstractBell miners (Manorina melanophrys; Meliphagidae) are a highly social and very aggressive honeyeater. They are despotic and cooperate in the defence of their territories against other bird species, leading to the almost complete exclusion of other avifauna from miner‐occupied regions. This study aimed to resolve some of the fine‐scale effects of bell miner aggression on avian diversity both within and adjacent to colonies to determine the true impact of a colony on local avifaunal abundance. Three areas, distributed throughout the range of the bell miner, were surveyed across both non‐breeding and breeding seasons to assess the temporal and spatial impacts of bell miner aggression on other bird species. Bell miner colonies were found to occupy very clearly defined areas and had the expected negative impact on avian diversity within their colony. The effects of bell miner colony presence on abundance and richness of avian species were found to cease at the colony boundary, with both recovering to normal levels immediately outside the bell miner colony. Whether bell miners were breeding or not, and irrespective of the amount of vegetation coverage, bell miner colonies were found to have relatively marginal impacts on avian richness and abundance. No impact of colony presence/absence was found on the richness or abundance of the avian species that dwell in the undergrowth, with some evidence that these species were actually more common at the colony edge. Our results demonstrate that the influence of bell miner colony presence upon avian biodiversity is restricted to the confines of the colony and does not radiate outwards into the surrounding habitat. Colony presence influences, therefore, have implications when considering the impact of bell miner behaviour on the diversity of insectivorous birds and processes, most notably the propagation of Bell Miner Associated Dieback.
Imputation of missing genotypes from low‐ to high‐density SNP panel in different population designs
Authors: He S. , Wang S. , Fu W. , Ding X. , Zhang Q. 
Published: November 2014

SummaryImputation of missing genotypes, in particular from low density to high density, is an important issue in genomic selection and genome‐wide association studies. Given the marker densities, the most important factors affecting imputation accuracy are the size of the reference population and the relationship between individuals in the reference (genotyped with high‐density panel) and study (genotyped with low‐density panel) populations. In this study, we investigated the imputation accuracies when the reference population (genotyped with Illumina BovineSNP50 SNP panel) contained sires, halfsibs, or both sires and halfsibs of the individuals in the study population (genotyped with Illumina BovineLD SNP panel) using three imputation programs (fimpute v2.2, findhap v2, and beagle v3.3.2). Two criteria, correlation between true and imputed genotypes and missing rate after imputation, were used to evaluate the performance of the three programs in different scenarios. Our results showed that fimpute performed the best in all cases, with correlations from 0.921 to 0.978 when imputing from sires to their daughters or between halfsibs. In general, the accuracies of imputing between halfsibs or from sires to their daughters were higher than were those imputing between non‐halfsibs or from sires to non‐daughters. Including both sires and halfsibs in the reference population did not improve the imputation performance in comparison with when only including halfsibs in the reference population for all the three programs.