bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental SES and family support as predictors of educational level: Testing the buffering effect of effortful control and peer support
Authors: Fakkel Matthijs , Peeters Margot , Branje Susan , Stevens Gonneke W. J. M. 
Published: August 2024

AbstractIntroductionExposure to family risk factors increases adolescents' chances of attaining a lower educational level. However, some adolescents attain a high educational level despite being exposed to family risk factors such as a lower parental socioeconomic status (SES) or receiving less family support.MethodUsing data from the Dutch TRAILS cohort study (NT1 = 2175; Mage = 11.1, SD = 0.55, 50.8% female), we investigated if higher levels of effortful control and peer support can buffer against the negative effects of a lower parental SES and less family support on educational level. Two multinomial logistic regressions were performed (from early to mid‐adolescence and from mid‐adolescence to young adulthood) with post hoc tests to contrast four ordinal educational levels: practical vocational, theoretical vocational, higher general, and (pre‐)university.ResultsAdolescents with a higher parental SES were consistently more likely to end up at a higher educational level, but family support was hardly associated with educational level. Neither effortful control nor peer support buffered the associations of parental SES and family support with educational level. Effortful control did have a positive direct (compensatory) effect on the educational level.ConclusionWe conclude that other individual competencies or more structural changes may be more helpful buffers for reducing socioeconomic inequalities in educational attainment.
A small shift, a major leap: Changing gender‐role attitudes among adolescents across two ethnic groups
Authors: Daw Suha , Scharf Miri 
Published: August 2024

AbstractIntroductionThe current study examined a growth mindset intervention designed to promote egalitarian gender role attitudes among adolescents during a pivotal stage of their development, as these attitudes may have important implications for their identity development, well‐being, and future life decisions.MethodsA sample of 181 eighth‐grade students (61% female, Mage = 13.14, SD = 0.42) from six Israeli schools participated in the study. The sample consisted of 49% Jewish and 51% Arab adolescents, including both Muslims and Christians. Adolescents engaged in a two‐session intervention that included videos and reflective writing tasks. Pre‐and postintervention, they completed self‐administered questionnaires assessing their gender‐role mindsets, attitudes toward women, and sexism. The data collection and intervention process took place from late 2021 to early 2023.ResultsAfter the intervention, there was an increase in growth mindsets and egalitarian attitudes towards women among adolescents, and a reduction in benevolent sexism and fixed gender‐role mindsets. Hostile sexism, however, remained unchanged. No significant sex or ethnic differences were found in the effectiveness of the intervention. Gender‐role mindsets mediated the association between the intervention and egalitarian attitudes, but not the association between the intervention and benevolent sexism.ConclusionsThe findings demonstrate the potential of brief and targeted growth mindset interventions in promoting favorable changes adolescents' attitudes towards gender roles. According to this study, despite prolonged gender‐role socialization, adolescents from diverse ethnic backgrounds can move towards more egalitarian attitudes and flexibility in gender roles through a rather targeted process. This finding is promising especially in adolescence, when stereotypes are often intensified.
UPCARE: Urinary Extracellular Vesicles‐Derived Prostate Cancer Assessment for Risk Evaluation
Authors: Jiang Shaoqin , Lu Feiting , Chen Jiadi , Jiao Yingzhen , Qiu Qingqing , Nian Xinwen , Qu Min , Wang Yan , Li Mengqiang , Liu Fei , Gao Xu 
Published: August 2024

AbstractIn the quest for efficient tumor diagnosis via liquid biopsy, extracellular vesicles (EVs) have shown promise as a source of potential biomarkers. This study addresses the gap in biomarker efficacy for predicting clinically significant prostate cancer (csPCa) between the Western and Chinese populations. We developed a urinary extracellular vesicles‐based prostate score (EPS) model, utilizing the EXODUS technique for EV isolation from 598 patients and incorporating gene expressions of FOXA1, PCA3, and KLK3. Our findings reveal that the EPS model surpasses prostate‐specific antigen (PSA) testing in diagnostic accuracy within a training cohort of 234 patients, achieving an area under the curve (AUC) of 0.730 compared to 0.659 for PSA (p = 0.018). Similarly, in a validation cohort of 101 men, the EPS model achieved an AUC of 0.749, which was significantly better than PSA's 0.577 (p < 0.001). Our model has demonstrated a potential reduction in unnecessary prostate biopsies by 26%, with only a 3% miss rate for csPCa cases, indicating its effectiveness in the Chinese population.
How is primary care nursing embedded in nursing undergraduate curricula: A mixed‐method study from four countries
Authors: Kako Mayumi , Halcomb Elizabeth , Mizukawa Mariko , Moriayama Michiko 
Published: August 2024

AbstractIntroductionGiven the increase in the primary care nursing workforce and the need to further grow nursing roles in the community understanding how this is included in undergraduate education is important. This study aimed to explore the inclusion of primary care in the undergraduate nursing education curriculum of four countries.MethodA mixed‐method design was employed to obtain a broader context of primary care nursing in nursing education and teaching approaches relating to primary care nursing. Subsequently, Australia, Canada, Spain, and Ireland were selected for this study because primary healthcare systems are established as a part of their healthcare system.ResultsIn total, 136 nursing faculties (40 in Australia, 35 in Canada, 46 in Spain, and 15 in Ireland) were invited to participate in this study. Of these, 27 responses were obtained (19.8% response rate). Following the survey phase, in‐depth interviews were conducted with 13 participants. The results indicated that the highest number was coded within the theme of “Understanding of PHC in the curriculum” (n = 108). The second highest number (n = 87) was within the theme of “Interpretation differences of PHC in curriculum,” and the third highest (n = 31) was coded within “Policy impact on health by national government and others.”ConclusionThe results emphasized the ambiguity of primary care within the undergraduate nursing curriculum and that interpretation and implementation into the curriculum largely depended on the school's intentions.
The aroma formation from fresh tea leaves of Longjing 43 to finished Enshi Yulu tea at an industrial scale
Authors: Sui Mengyuan , Wang Lili , Xue Rong , Xiang Jun , Wang Yufei , Yuan Yuan , Pu Qian , Fang Xin , Liu Bin , Hu Xingming , Liu Xiaoying , Huang Youyi 
Published: August 2024

AbstractBACKGROUNDEnshi Yulu tea (ESYL) is the most representative of steamed green tea in China, but its aroma formation in processing is unclear. Thus, the ESYL volatiles during the whole industrial processing were investigated using headspace solid‐phase microextraction coupled with gas chromatography–mass spectrometry.RESULTSA total of 134 volatiles were identified. Among these, 31 differential volatiles [P < 0.05 and variable importance in projection (VIP) > 1] and 25 key volatiles [relative odor activity value (rOAV) and/or the ratio of each rOAV to the maximum rOAV (ROAV) > 1.0] were screened out, wherein β‐ionone and nonanal were the most key odorants. Besides, the sensory evaluation combined with multivariate statistical analysis of volatiles pinpointed spreading, fixation, first drying, and second drying as the key processing steps that have a pronounced influence on the aroma quality of ESYL. Furthermore, the oxidative degradation of unsaturated fatty acids, synthesis of monoterpenes, and degradation of carotenoids were the main metabolic pathway for the formation of key odorants.CONCLUSIONThe study provides comprehensive insights into the volatile characteristics during the industrial processing of ESYL and promote our understanding of the aroma formation in steamed green teas. © 2024 Society of Chemical Industry.
Prophylactic effects of Tibetan goat kefir on depression‐like behaviors in chronic unpredictable stress model through the gut–brain axis
Authors: Sun Yuhan , Zhao Hongfan , Chang Mengjia , Yue Tianli , Yuan Yahong , Shi Yiheng 
Published: August 2024

AbstractBACKGROUNDDepression is a common psychological disorder, and traditional therapeutic drugs often result in side effects such as emesis, dry mouth, headache, dysentery and constipation. Probiotics and goat milk have garnered widespread attention for their ability to modulate immune function and regulate the endocrine system, and for their anti‐inflammatory effects. In this work, the effects of Tibetan goat kefir on the behavior, immune status, neuroendocrine response and gut microbiological composition of chronic unpredictable mild stress (CUMS) mouse models were evaluated.RESULTSThe results indicated that Tibetan kefir goat milk significantly alleviated behavioral despair in mice. Furthermore, the results demonstrated that Tibetan kefir goat milk mitigated the inflammatory response in the mice and moderated the hyperactivity of the hypothalamic–pituitary–adrenal axis and the expression of brain‐derived neurotrophic factor. Meanwhile, chronic stress‐induced gut microbial abnormalities were restored. In addition, the correlation between gut microbiota and nervous system was evaluated.CONCLUSIONThese results explained the potential mechanism of Tibetan kefir in the antidepressant effect on the CUMS model and enriched diets for depressed patients. © 2024 Society of Chemical Industry.
Palmar Fibromatosis, Updated Review With Relationship to the A1 Pulley, Trigger Finger, and Presence of the Sonographic Comb Sign
Authors: Pepperday Cody A. , Murthy Naveen , Kakar Sanjeev , McKenzie Gavin A. 
Published: August 2024

ObjectivesUpdated retrospective review of the sonographic appearance of palmar fibromatosis (PF) with evaluation of the utility of the Comb Sign previously described in plantar fibromas. Additional evaluation was conducted on the location relative to the flexor tendon, anatomic proximity of palmar fibromas to the A1 pulley and evaluate any potential association with trigger finger.MethodsMedical record and imaging review was performed from 2017 to 2023, for patients with a new onset ultrasound or clinical diagnosis of PF. Clinical associations and imaging morphology were reviewed including presence of the Comb Sign, fibroma association with the A1 pulley, and fibroma association with trigger finger.ResultsExactly 87 total fibromas in 53 patients were evaluated. The Comb Sign was present in 39% of fibromas, usually seen in transverse plane, more prevalent in multifocal disease and larger fibromas. Most (72%) palmar fibromas were within 1 cm of, contacted, or covered the A1 pulley (P < .001). Lateral extension beyond the flexor tendon axis can be seen (44%). Trigger finger and tenosynovitis were rare. However, volume and SI dimension of fibromas were associated with tenosynovitis (P < .0001) and all nine patients with concomitant trigger finger had fibromas within 1 cm from the A1 pulley.ConclusionsThe Comb Sign can aid in sonographic diagnosis of PF. Lateral extension of fibromas can occur. Most palmar fibromas have a significant intimate association with the A1 pulley, and presence of trigger finger with adjacent palmar fibroma can exist and is important for hand surgeons to know preoperatively.
LncRNA NR2F2‐AS1 inhibits the progression of oral squamous cell carcinoma by mediating the miR‐32‐5p/SEMA3A axis
Authors: Qin Shi‐Yu , Li Bo , Liu Ji‐Mu , Lv Qiu‐Li , Zeng Xiang‐Lin 
Published: August 2024

AbstractPrevious studies have supported a tumor‐suppressive role of semaphorin 3A (SEMA3A) in several tumors including oral squamous cell carcinoma (OSCC). However, in‐depth characterization of the role of SEMA3A in OSCC and the underlying molecular mechanisms is lacking. Gene and protein expressions were detected using quantitative real‐time PCR, western blot assay, and immunohistochemistry. OSCC cell metastasis was evaluated using Transwell and angiogenesis of human umbilical vein endothelial cells (HUVECs) was determined using tube formation assay. The interactions among molecules were predicted using bioinformatics analysis and validated using luciferase activity experiment and RNA immunoprecipitation assay. Pulmonary metastasis was evaluated using hematoxylin and eosin staining after constructing a lung metastasis tumor model in mice. SEMA3A expression was decreased in OSCC cells and its overexpression led to suppression of epithelial‐mesenchymal transition (EMT), migration, and invasion of OSCC cells and angiogenesis of HUVECs. miR‐32‐5p was identified as an upstream molecule of SEMA3A and long non‐coding RNA NR2F2 antisense RNA 1 (NR2F2‐AS1) was validated as an upstream gene of miR‐32‐5p. Further experiments revealed that the inhibitory effects of NR2F2‐AS1 overexpression on EMT, migration, invasion of OSCC cells, and angiogenesis of HUVECs as well as tumor growth and metastasis in mice were mediated via the miR‐32‐5p/SEMA3A axis. To conclude, NR2F2‐AS1 may attenuate OSCC cell metastasis and angiogenesis of HUVECs and suppress tumor growth and metastasis in mice via the miR‐32‐5p/SEMA3A axis.
A higher incidence of chondral injuries on the medial femoral condyle in concomitant ACL ruptures, no significant difference in treatment: A systematic review
Authors: Hanlon Jack , Máté Miklós , de Jonge Róbert , Bäcker Henrik C. , Panics Gergely 
Published: August 2024

AbstractPurposeThe associated damage to articular cartilage in anterior cruciate ligament (ACL) injured patients is a well‐recognized phenomenon; however, there is a relative paucity in the literature regarding the different treatment techniques and outcomes. The purpose of this systematic review was to identify patients treated for acute ACL rupture and associated cartilage injury, with interest in the surgical management of these chondral injuries and any difference in patient‐reported outcome measures (PROMs) differing techniques.MethodsA systematic review was performed looking for treatment or management of International Cartilage Repair Society grade 3 or 4 articular cartilage injury at the time of ACL reconstruction.ResultsSeventeen studies fit the criteria, a total of 892 patients were included, 64.6% were male with a mean age of 33.7 and the average time to follow‐up was 41.7 months. 68.2% of the lesions were on the medial femoral condyle (MFC) with a mean lesion size of 3.9 cm2. Six different operative methods of dealing with chondral lesions were identified, there was no significant difference in PROMs between the techniques, although there was a significant difference between the preoperative and postoperative outcome measures.ConclusionsThe systematic review found that chondral defects on the MFC are more common in concomitant ACL injuries, despite the pattern of bone bruising being more common on the lateral femoral condyle as reported in the literature. It also found no significant difference in the PROMs between the six different techniques identified for the concomitant management of ACL reconstruction and chondral defects.Level of EvidenceLevel II.
Machine‐learning models for shoulder rehabilitation exercises classification using a wearable system
Authors: Sassi Martina , Carnevale Arianna , Mancuso Matilde , Schena Emiliano , Pecchia Leandro , Longo Umile Giuseppe 
Published: August 2024

AbstractPurposeThe objective of this study is to train and test machine‐learning (ML) models to automatically classify shoulder rehabilitation exercises.MethodsThe cohort included both healthy and patients with rotator‐cuff (RC) tears. All participants performed six shoulder rehabilitation exercises, following guidelines developed by the American Society of Shoulder and Elbow Therapists. Each exercise was repeated six times, while wearing a wearable system equipped with three magneto‐inertial sensors. Six supervised machine‐learning models (k‐Nearest Neighbours, Support Vector Machine, Decision Tree, Random Forest (RF), Logistic Regression and Adaptive Boosting) were trained for the classification. The algorithms' ability to accurately classify exercise activities was evaluated using the nested cross‐validation method, with different combinations of outer and inner folds.ResultsA total of 19 healthy subjects and 17 patients with complete RC tears were enroled in the study. The highest classification performances were achieved by the RF classifier, with an accuracy of 89.91% and an F1‐score of 89.89%.ConclusionThe results of this study highlight the feasibility and effectiveness of using wearable sensors and ML algorithms to accurately classify shoulder rehabilitation exercises. These findings suggest promising prospects for implementing the proposed wearable system in remote home‐based monitoring scenarios. The ease of setup and modularity of the system reduce user burden enabling patient‐driven sensor positioning.Level of EvidenceLevel III.
Supply chain financing decision with installment redemption under dynamic pledge
Authors: Cai Xin , Li Dongdong , Chu Jiaojie , Liu Xueyong 
Published: August 2024

AbstractIn this paper, the dynamic pledge financing decision problem of a borrowing enterprise is studied in the context of a supply chain finance system that includes a financial institution and a borrowing enterprise (small and medium‐sized enterprises [SMEs]). The optimal Inventory pledge, as well as redemption decisions of the borrowing enterprise, are analyzed under the consideration of constant and changing redemption prices, respectively, and the effects of the main parameters on the optimal decisions are discussed. It found that (1) when the redemption price is constant, the borrowing enterprise's optimal quantity of inventory pledge increases as the initial inventory quantity increases or the redemption price decreases; (2) when the redemption price varies, the borrowing enterprise's optimal inventory redemption quantity decreases as the initial inventory pledge and the redemption price increase; and (3) the borrowing enterprise's redemption decision is affected by the previous period's redemption quantity and the actual sales quantity. The conclusions of this paper not only provide suggestions for SMEs to make inventory pledge financing decisions but also provide references for financial institutions to formulate relevant financing rules.
XSIM: A structural similarity index measure optimized for MRI QSM
Authors: Milovic Carlos , Tejos Cristian , Silva Javier , Shmueli Karin , Irarrazaval Pablo 
Published: August 2024

AbstractPurposeThe structural similarity index measure (SSIM) has become a popular quality metric to evaluate QSM in a way that is closer to human perception than RMS error (RMSE). However, SSIM may overpenalize errors in diamagnetic tissues and underpenalize them in paramagnetic tissues, resulting in biasing. In addition, extreme artifacts may compress the dynamic range, resulting in unrealistically high SSIM scores (hacking). To overcome biasing and hacking, we propose XSIM: SSIM implemented in the native QSM range, and with internal parameters optimized for QSM.MethodsWe used forward simulations from a COSMOS ground‐truth brain susceptibility map included in the 2016 QSM Reconstruction Challenge to investigate the effect of QSM reconstruction errors on the SSIM, XSIM, and RMSE metrics. We also used these metrics to optimize QSM reconstructions of the in vivo challenge data set. We repeated this experiment with the QSM abdominal phantom. To validate the use of XSIM instead of SSIM for QSM quality assessment across a range of different reconstruction techniques/algorithms, we analyzed the reconstructions submitted to the 2019 QSM Reconstruction Challenge 2.0.ResultsOur experiments confirmed the biasing and hacking effects on the SSIM metric applied to QSM. The XSIM metric was robust to those effects, penalizing the presence of streaking artifacts and reconstruction errors. Using XSIM to optimize QSM reconstruction regularization weights returned less overregularization than SSIM and RMSE.ConclusionXSIM is recommended over traditional SSIM to evaluate QSM reconstructions against a known ground truth, as it avoids biasing and hacking effects and provides a larger dynamic range of scores.
Numerical prediction strategy of fabric in‐plane permeability considering realistic inter‐ and intra‐tow geometry
Authors: Cheng Long , Chen Junzhen , Stapleton Scott E. , Wang Yongkang , Jiang Jianjun , Li Yujun 
Published: August 2024

AbstractPermeability quantifies the flow conductivity of fabric reinforcements and is key to predicting mold filling times and resin flow in liquid composite molding (LCM). Flow depends on the micron‐level channels within the tows and the millimeter‐level channels between them. This study presents a general multi‐scale permeability prediction framework for fabrics considering realistic inter‐ and intra‐tow geometry. A misaligned fiber representative volume element model was constructed by a random perturbation method at the micro‐scale with orientation parameters identified from microscopic images of the cross‐section. At the meso‐scale, a tow cross‐section wrapping algorithm and an interference elimination algorithm were proposed to construct continuous as‐woven tows from the virtual fiber compression simulation. The governing fluid dynamics equations were solved to obtain the flow field within the multi‐scale gaps and compute the permeability. The simplified model's permeability predictions differed from experimental results by 12.7% to 16%. This work provides valuable insights for further research and development in LCM.Highlights
Fabric permeability framework considers realistic tow geometry for prediction.
Microscale misaligned fiber SVE model predicts tow permeability.
Adaptive winding & interference algorithms aid tow description transition.
A simplified model predicts permeability reasonably without 3D measurements.