bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prädiktoren der Behandelbarkeit nach § 64 StGB aus Therapeutensicht
Authors: Querengässer Jan , Hoffmann Klaus , Ross Thomas 
Published: October 2014

Einleitung: Der Maßregelvollzug nach § 64 StGB kämpft mit steigender Belegung und hohen Erledigungsquoten. Zahlreiche Studien untersuchten daher behandlungsprognostisch relevante Patienteneigenschaften. Deren Gesamtschau ergibt ein uneinheitliches Bild von meist schwachen Prädiktoren. Zielsetzung: Beantwortet werden soll im Wesentlichen 1) inwieweit die empirischen Befunde der praktischen Behandlungserfahrung entsprechen; 2) welche weiteren Prädiktoren sich daraus ergeben.Methodik: Anhand von Fragebögen schätzten 35 MRV-Therapeuten den prognostischen Wert von 30 Prädiktorvariablen ein. Die Eigennennung weiterer wurde erbeten.Ergebnisse: Trotz deutlicher Heterogenität der Einschätzungen spiegeln sich gesicherte empirische Befunde wider, z. B. intrinsische Motivation als positiver und psychopathische Persönlichkeitszüge als negativer Prognosefaktor für den Behandlungserfolg. Weitere Variablen umfassen Aspekte delinquenter Sozialisation als negative Prädiktoren – Intelligenz, weibliches Geschlecht, Beziehungs- und sprachliche Ausdrucksfähigkeit als positive. Schlussfolgerung: Die Prognosefaktoren für den Behandlungserfolg nach § 64 StGB werden in der Praxis uneinheitlich bewertet. Als Mediator kommt die individuell verschiedene Behandlungserfahrung in Frage.
The Digit Span Backwards Task
Authors: Hilbert Sven , Nakagawa Tristan T. , Puci Patricia , Zech Alexandra , Bühner Markus 
Published: October 2014

Abstract. The “digit span backwards” (DSB) is the most commonly used test in clinical neuropsychology to assess working memory capacity. Yet, it remains unclear how the task is solved cognitively. The present study was conducted to examine the use of visual and verbal cognitive strategies in the DSB. Further, the relationship between the DSB and a complex span task, based on the Simultaneous Storage and Processing task ( Oberauer et al., 2003 ), was investigated. Visualizers performed better than verbalizers in the dual task condition (rPB = .23) only when the relevant digits were presented optically. Performance in the DSB correlated only weakly with the complex span task in all conditions (all τ ≤ .21). The results indicate that the processing modality is determined by the preference for a cognitive strategy rather than the presentation modality and suggest that the DSB measures different working aspects than commonly used experimental working memory tasks.
Quantum signatures of a molecular nanomagnet in direct magnetocaloric measurements
Authors: Sharples Joseph W. , Collison David , McInnes Eric J. L. , Schnack Jürgen , Palacios Elias , Evangelisti Marco 
Published: October 2014

AbstractGeometric spin frustration in low-dimensional materials, such as the two-dimensional kagome or triangular antiferromagnetic nets, can significantly enhance the change of the magnetic entropy and adiabatic temperature following a change in the applied magnetic field, that is, the magnetocaloric effect. In principle, an equivalent outcome should also be observable in certain high-symmetry zero-dimensional, that is, molecular, structures with frustrated topologies. Here we report experimental realization of this in a heptametallic gadolinium molecule. Adiabatic demagnetization experiments reach ~200 mK, the first sub-Kelvin cooling with any molecular nanomagnet, and reveal isentropes (the constant entropy paths followed in the temperature-field plane) with a rich structure. The latter is shown to be a direct manifestation of the trigonal antiferromagnetic net structure, allowing study of frustration-enhanced magnetocaloric effects in a finite system.
Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin
Authors: Verma Santosh K. , Leikina Evgenia , Melikov Kamran , Chernomordik Leonid V. 
Published: October 2014

Macrophage fusion that leads to osteoclast formation is one of the most important examples of cell–cell fusion in development, tissue homoeostasis and immune response. Protein machinery that fuses macrophages remains to be identified. In the present study, we explored the fusion stage of osteoclast formation for RAW macrophage-like murine cells and for macrophages derived from human monocytes. To uncouple fusion from the preceding differentiation processes, we accumulated fusion-committed cells in the presence of LPC (lysophosphatidylcholine) that reversibly blocks membrane merger. After 16 h, we removed LPC and observed cell fusion events that would normally develop within 16 h develop instead within 30–90 min. Thus, whereas osteoclastogenesis, generally, takes several days, our approach allowed us to focus on an hour in which we observe robust fusion between the cells. Complementing syncytium formation assay with a novel membrane merger assay let us study the synchronized fusion events downstream of a local merger between two plasma membranes, but before expansion of nascent membrane connections and complete unification of the cells. We found that the expansion of membrane connections detected as a growth of multinucleated osteoclasts depends on dynamin activity. In contrast, a merger between the plasma membranes of the two cells was not affected by inhibitors of dynamin GTPase. Thus dynamin that was recently found to control late stages of myoblast fusion also controls late stages of macrophage fusion, revealing an intriguing conserved mechanistic motif shared by diverse cell–cell fusion processes.
Predictable transcriptome evolution in the convergent and complex bioluminescent organs of squid
Authors: Pankey M. Sabrina , Minin Vladimir N. , Imholte Greg C. , Suchard Marc A. , Oakley Todd H. 
Published: October 2014

Significance
Unless there are strong constraints, the probability of complex organs originating multiple times through similar trajectories should be vanishingly small. Here, we report that similar light-producing organs (photophores) evolved separately in two squid species, yet each organ expresses similar genes at comparable levels. Gene expression is so similar that overall expression levels alone can predict organ identity, even in separately evolved traits of squid species separated by tens of millions of years. The striking similarity of expression of hundreds of genes in distinct photophores indicates complex trait evolution may sometimes be more constrained and predictable than expected, either because of internal factors, like a limited array of suitable genetic building blocks, or external factors, like natural selection favoring an optimum.
IKKβ is an IRF5 kinase that instigates inflammation
Authors: Ren Junyao , Chen Xiang , Chen Zhijian J. 
Published: October 2014

Significance
Inflammation is an important arm of host defense against microbial infections, but excessive inflammation can cause human diseases. Interferon regulatory factor 5 (IRF5) is a key regulator of inflammatory responses, controlling the expression of many proinflammatory cytokines. Mutations and dysregulation of IRF5 have been linked to autoimmune and autoinflammatory diseases in humans; however, how IRF5 is activated is not well understood. We report that the kinase IKKβ, which is known to regulate the Rel/nuclear factor kappa B (NF-κB) family of transcription factors, phosphorylates IRF5 at a specific serine residue, and that this phosphorylation is critical for IRF5 activation and cytokine production. Thus, IKKβ regulates two master transcription factors, NF-κB and IRF5, which coordinately control gene expression to mediate inflammatory responses.
flowDensity: reproducing manual gating of flow cytometry data by automated density-based cell population identification
Authors: Malek Mehrnoush , Taghiyar Mohammad Jafar , Chong Lauren , Finak Greg , Gottardo Raphael , Brinkman Ryan R. 
Published: October 2014

Summary: flowDensity facilitates reproducible, high-throughput analysis of flow cytometry data by automating a predefined manual gating approach. The algorithm is based on a sequential bivariate gating approach that generates a set of predefined cell populations. It chooses the best cut-off for individual markers using characteristics of the density distribution. The Supplementary Data is linked to the online version of the manuscript.
Availability and implementation: R source code freely available through BioConductor (http://master.bioconductor.org/packages/devel/bioc/html/flowDensity.html.). Data available from FlowRepository.org (dataset FR-FCM-ZZBW).
Contact: rbrinkman@bccrc.ca
Supplementary information: Supplementary Data are available at Bioinformatics online.
jNMFMA: a joint non-negative matrix factorization meta-analysis of transcriptomics data
Authors: Wang Hong-Qiang , Zheng Chun-Hou , Zhao Xing-Ming 
Published: October 2014

Motivation: Tremendous amount of omics data being accumulated poses a pressing challenge of meta-analyzing the heterogeneous data for mining new biological knowledge. Most existing methods deal with each gene independently, thus often resulting in high false positive rates in detecting differentially expressed genes (DEG). To our knowledge, no or little effort has been devoted to methods that consider dependence structures underlying transcriptomics data for DEG identification in meta-analysis context.
Results: This article proposes a new meta-analysis method for identification of DEGs based on joint non-negative matrix factorization (jNMFMA). We mathematically extend non-negative matrix factorization (NMF) to a joint version (jNMF), which is used to simultaneously decompose multiple transcriptomics data matrices into one common submatrix plus multiple individual submatrices. By the jNMF, the dependence structures underlying transcriptomics data can be interrogated and utilized, while the high-dimensional transcriptomics data are mapped into a low-dimensional space spanned by metagenes that represent hidden biological signals. jNMFMA finally identifies DEGs as genes that are associated with differentially expressed metagenes. The ability of extracting dependence structures makes jNMFMA more efficient and robust to identify DEGs in meta-analysis context. Furthermore, jNMFMA is also flexible to identify DEGs that are consistent among various types of omics data, e.g. gene expression and DNA methylation. Experimental results on both simulation data and real-world cancer data demonstrate the effectiveness of jNMFMA and its superior performance over other popular approaches.
Availability and implementation: R code for jNMFMA is available for non-commercial use viahttp://micblab.iim.ac.cn/Download/.
Contact: hqwang@ustc.edu
Supplementary information: Supplementary Data are available at Bioinformatics online.
mimicMe: a web server for prediction and analysis of host-like proteins in microbial pathogens
Authors: Petrenko Pavel , Doxey Andrew C. 
Published: October 2014

Summary: mimicMe is a web server for prediction and analysis of host-like proteins (mimics) encoded by microbial pathogens. Users select a host species and any set of pathogen and control proteomes (bacterial, fungal, protozoan or viral) and mimicMe reports host-like proteins that are unique to or enriched among pathogens. Additional server features include visualization of structural similarities between pathogen and host proteins as well as function-enrichment analysis.
Availability and implementation: mimicMe is available at http://mimicme.uwaterloo.ca
Contact: acdoxey@uwaterloo.ca
E-MEM: efficient computation of maximal exact matches for very large genomes
Authors: Khiste Nilesh , Ilie Lucian 
Published: October 2014

Motivation: Alignment of similar whole genomes is often performed using anchors given by the maximal exact matches (MEMs) between their sequences. In spite of significant amount of research on this problem, the computation of MEMs for large genomes remains a challenging problem. The leading current algorithms employ full text indexes, the sparse suffix array giving the best results. Still, their memory requirements are high, the parallelization is not very efficient, and they cannot handle very large genomes.
Results: We present a new algorithm, efficient computation of MEMs (E-MEM) that does not use full text indexes. Our algorithm uses much less space and is highly amenable to parallelization. It can compute all MEMs of minimum length 100 between the whole human and mouse genomes on a 12 core machine in 10 min and 2 GB of memory; the required memory can be as low as 600 MB. It can run efficiently genomes of any size. Extensive testing and comparison with currently best algorithms is provided.
Availability and implementation: The source code of E-MEM is freely available at: http://www.csd.uwo.ca/∼ilie/E-MEM/
Contact: ilie@csd.uwo.ca
Supplementary information: Supplementary Data are available at Bioinformatics online.
Rupture velocity inferred from near-field shear strain analysis
Authors: Causse M. , Cornou C. , Bécasse J. 
Published: October 2014

AbstractWe propose a new technique to determine the rupture velocity of large strike slip earthquakes. By means of simple numerical ground motion simulations, we show that when the rupture penetrates a shallow layer of sediment or fractured rock, shock waves propagate along the surface fault trace in the forward rupture direction. Such shock waves, which are insensitive to the complexity of slip over the fault plane, propagate at a phase velocity equal to the rupture speed. We show that those shock waves can be easily isolated in the frequency domain, and that phase velocity can then be simply obtained from shear strain.
Mesozoic mammals of China: implications for phylogeny and early evolution of mammals
Authors: Meng Jin 
Published: October 2014

AbstractAll Mesozoic mammaliaforms reported from China are briefly documented herein. These forms can be divided into at least five major assemblages: Lufeng, Yanliao (Daohugou), Jehol, Fuxin and Bayan Mandahu, ranging from the Early Jurassic to the Late Cretaceous periods. Although the temporal and geographic distributions of these mammaliaforms are not dense, the records do reveal a pattern that is generally consistent with patterns that have been recognized globally. The initial stage of mammalian evolution was represented by stem mammaliaforms or primitive ‘triconodonts’ from the Lufeng. This was followed by the Middle-Late Jurassic Yanliao episode that showed a high diversity and disparity of mammaliaforms in which terrestrial, swimming, arboreal and gliding species were present. The disparity, at least in molar morphology and types of locomotion, decreased but the diversity persisted into the Cretaceous, a period that was dominated by eutriconodontans, multituberculates and trechnotherians. The superb specimens from nearly all major groups of Mesozoic mammals in China provided a great amount of information that contributed to our understanding on some major issues in phylogeny and the early evolution of mammals, such as divergences of mammals and the evolution of the mammalian middle ear. A hypothesis on the transformation of the allotherian tooth pattern is proposed as an example to illustrate the potential for future studies of mammalian evolution.
Jasmonoyl-l-Isoleucine Coordinates Metabolic Networks Required for Anthesis and Floral Attractant Emission in Wild Tobacco (Nicotiana attenuata)
Authors: Stitz Michael , Hartl Markus , Baldwin Ian T. , Gaquerel Emmanuel 
Published: October 2014

AbstractJasmonic acid and its derivatives (jasmonates [JAs]) play central roles in floral development and maturation. The binding of jasmonoyl-l-isoleucine (JA-Ile) to the F-box of CORONATINE INSENSITIVE1 (COI1) is required for many JA-dependent physiological responses, but its role in anthesis and pollinator attraction traits remains largely unexplored. Here, we used the wild tobacco Nicotiana attenuata, which develops sympetalous flowers with complex pollination biology, to examine the coordinating function of JA homeostasis in the distinct metabolic processes that underlie flower maturation, opening, and advertisement to pollinators. From combined transcriptomic, targeted metabolic, and allometric analyses of transgenic N. attenuata plants for which signaling deficiencies were complemented with methyl jasmonate, JA-Ile, and its functional homolog, coronatine (COR), we demonstrate that (1) JA-Ile/COR-based signaling regulates corolla limb opening and a JA-negative feedback loop; (2) production of floral volatiles (night emissions of benzylacetone) and nectar requires JA-Ile/COR perception through COI1; and (3) limb expansion involves JA-Ile-induced changes in limb fresh mass and carbohydrate metabolism. These findings demonstrate a master regulatory function of the JA-Ile/COI1 duet for the main function of a sympetalous corolla, that of advertising for and rewarding pollinator services. Flower opening, by contrast, requires JA-Ile signaling-dependent changes in primary metabolism, which are not compromised in the COI1-silenced RNA interference line used in this study.
Lifestyle pattern underlying organic and traditional food consumption
Authors: Nikolić Aleksandra , Uzunović Mirza , Spaho Nermina 
Published: October 2014

Purpose
– The purpose of this paper is to set out to define lifestyle pattern framing behavior shared by traditional food products (TFP) and organic foods (OF) consumers to identify, if possible, a generic way to facilitate development of TFP and OF production in order to pave the road for more sustainable food production and consumption.

Design/methodology/approach
– A convenience, non-probabilistic sample (n=800) was designed and customer survey was conducted in December 2013 in Bosnia and Herzegovina. Exploratory factor analysis and cluster analysis were performed to identify common lifestyle pattern shaping consumption of both products’ groups.

Findings
– TFP and OF consumption patterns are driven by common lifestyle pattern defined by concern for welfare of all people, social equality and nature; and by consumers’ belief that food is a basis of their health, while food and cooking make an important part of family life.

Practical implications
– This study shows that public and private promotion/marketing policies for OF and TFP need to be designed in a way that strongly emphasizes their symbolic meaning that elicits in consumers feeling of belonging to both local community and their family, and at the same time highlights the level of social responsibility of their producers. In addition, this study contributes to the body of knowledge in this area.

Originality/value
– No similar study has been done to date that was focussed on identifying common combination of lifestyle factors that frame and drive customers’ tendency to purchase either TFP or OF products. This study offers a unique and valuable insight into topics and values around which a generic public or private promotional strategy for the two product groups would evolve, and which will decide effectiveness of any such strategy.
The e-Duke Scholarly Collection: e-book v. print use
Authors: Goodwin Cathy 
Published: October 2014

Purpose
– The aim of this study is to compare print and e-book use for identical titles in the e-Duke Scholarly Collection (e-DSC) from 2011 to 2013 to determine format preference for a discrete collection of titles in humanities and social sciences.

Design/methodology/approach
– Use statistics for the e-DSC were downloaded from the e-book platform by title and call number to determine use by title and subject. Circulation statistics were culled from the library’s integrated library system for the same titles to compare e-book use to that of the same print title.

Findings
– Although e-books had a high number of titles with use as a per cent of the collection, examination of substantive use shows a slight preference for print. While 73 per cent of the e-books garnered enough interest to click on them, only 12 per cent had substantive use.

Research limitations/implications
– The e-DSC changed platforms in December 2013. The new platform does not require users to create an account to download e-book sections and digital rights management limitations have been removed. The same examination of collection use in 2.5 years on the new platform will provide an interesting comparison on the function of platform on e-book use.

Originality/value
– The comparison of identical print and e-titles is less studied and includes the examination of “substantive use” in comparing print to e-book use.
SEC announces first investment adviser ‘pay-to-play’ enforcement action
Authors: Norman Goldberger M. , C. Grugan John , O’Neil Christine , N. Stanley Tesia 
Published: October 2014

Purpose
– To explain the first enforcement action the USA Securities and Exchange Commission (SEC) has brought under “pay to play” rules for investment advisers since those rules were adopted nearly four years ago.

Design/methodology/approach
– First, the article provides a summary of the SEC enforcement action against TL Ventures Inc., a Philadelphia-area private equity firm. Next, the article provides a historical context and some key provisions of the rules. Finally, the article provides political contribution policy and procedure recommendations.

Findings
– Political corruption in the municipal market has been a focus of the SEC for several years and is likely to continue to be a top priority. Investment advisers should ensure they have sufficient policies and procedures in place to avoid a two-year ban on business with a state or local government as the result of a political contribution.

Originality/value
– The article provides the facts underlying the SEC’s enforcement action, the historical context of municipal market pay-to-play rules, a summary of the pay-to-play prohibitions, and recommendations for avoiding rule violations. The article would be of interest to investment advisers, public pension plans, municipal securities underwriters, brokers, and dealers as well as state and local governments.
Bridging the academia-practitioner divide: the case of “service theater”
Authors: Daly Aidan , Baron Steve , J. Dorsch Michael , P. Fisk Raymond , J. Grove Stephen , Harris Kim , Harris Richard 
Published: October 2014

Purpose– This paper aims to demonstrate the applicability of a theatrical framework for improving the effectiveness of the knowledge transfer of service research findings to practitioners.Design/methodology/approach– A case study approach is adopted. The operation of a practitioner-oriented seminar is examined through a theatrical lens to establish the extent to which direction, audience participation and creativity, emotions and visual aesthetics can contribute to bridging the academia-practitioner divide.Findings– Planning a practitioner-oriented seminar performance is as important as planning the program content. Effective knowledge transfer requires active audience engagement, activation of favorable audience emotions and an enjoyable learning process. The lack of these requirements can render written dissemination by journal papers relatively ineffective in reaching and engaging practitioners.Research limitations/implications– Findings are based on one case study: a seminar delivered to practitioners on “service theater”.Practical implications– In addition to face-to-face seminars, contemporary dissemination methods (webinars, podcasts) can apply the theatrical lessons introduced and evaluated. Practitioners do not respond positively to only written declarative information, through academic papers and/or PowerPoint slides, from academicians.Originality/value– The article recognizes that dissemination of service research findings is, itself, a service, requiring depth of thought and understanding.