bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of the Tai Chi intervention on self-esteem and self-confidence perception in adult populations: a systematic review and meta-analysis
Authors: CHAIR Sek Ying , LAW Bernard Man Hin , CHAN Aileen Wai Kiu , GAO Ruitong 
Published: February 2025

Abstract

Background
Self-esteem is a psychological outcome that is positively related to mental and psychological health, one of the most important elements in nursing. Developing strategies for self-esteem promotion is therefore of great importance in nursing practice. Previous reviews suggested that exercise interventions such as Tai Chi practice may confer both mental and physical benefits in humans, but reviews on the effect of Tai Chi exercise on self-esteem of adults are lacking. Thus, this systematic review and meta-analysis was conducted to evaluate the effectiveness of Tai Chi interventions in promoting self-esteem among adults.

Methods
We included randomized controlled trials that investigated Tai Chi interventions in adults, where self-esteem and/or self-confidence were reported as outcomes. The literature search was conducted in ten electronic databases. Two independent reviewers performed abstract and full-text screening using Covidence. These reviewers also independently extracted data from the included studies, and conducted critical appraisal of their methodological quality, using the revised Cochrane risk-of-bias tool for randomized trials (RoB2).

Results
Eleven studies were included in the review, of which all were rated as having high risk of bias or some concerns in their methodological quality. Our meta-analysis demonstrated that Tai Chi intervention can significantly improve self-esteem among adults, where the post-intervention self-esteem score was higher among the intervention participants compared to the controls (standardized mean difference: 0.46; 95% CI: 0.18–0.74; p = 0.001). Sensitivity analyses by excluding studies not reporting data using means and standard deviations revealed similar findings. One study also showed a positive effect of Tai Chi intervention on self-confidence perception.

Conclusions
Tai Chi interventions have a moderately positive effect on self-esteem among adults. Tai Chi exercise classes could be a potential strategy to implement within communities, especially among individuals in higher need to improve their self-esteem such as older adults and patients having chronic illnesses that have detrimental effects on their psychological well-being. However, given the high risk of bias in most studies, caution is advised before recommending widespread implementation. Further high-quality research, including qualitative studies exploring how Tai Chi can improve self-esteem, is needed to strengthen the evidence base.
Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial
Authors: Gaudilliere Brice , Xue Lei , Tsai Amy S. , Gao Xiaoxiao , McAllister Tiffany N. , Tingle Martha , Porras Gladys , Feinstein Igor , Feyaerts Dorien , Verdonk Franck , Sabayev Maximilian , Hedou Julien , Ganio Edward A. , Berson Eloïse , Becker Martin , Espinosa Camilo , Kim Yeasul , Lehallier Benoit , Rawner Esther , Feng Chunmiao , Amanatullah Derek F. , Huddleston James I. , Goodman Stuart B. , Aghaeepour Nima , Angst Martin S. 
Published: February 2025

Abstract

Background
Preclinical evidence suggests that young plasma has beneficial effects on multiple organ systems in aged mice. Whether young plasma exerts beneficial effects in an aging human population remains highly controversial. Despite lacking data, young donor plasma infusions have been promoted for age-related conditions. Given the preclinical evidence that young plasma exerts beneficial effects by attenuating inflammation, this study examined whether administering a young plasma protein fraction to an elderly population would exert anti-inflammatory and immune modulating effects in humans, using surgery as a tissue injury model.

Methods
This double-blind, placebo-controlled study enrolled and randomized 38 patients undergoing major joint replacement surgery. Patients received four separate infusions of a plasma protein fraction derived from young donors, or placebo one day before surgery, before and after surgery on the day of surgery, and one day after surgery. Blood specimens for proteomic and immunological analyses were collected before each infusion. Based on the high-content assessment of circulating plasma proteins with single-cell analyses of peripheral immune cells, proteomic signatures and cell-type-specific signaling responses that separated the treatment groups were derived with regression models.

Results
Elastic net regression models revealed that administration a young plasma protein fraction significantly altered the proteomic (AUC = 0.796, p = 0.002) and the cellular immune response (AUC 0.904, p < 0.001) to surgical trauma resulting in signaling pathway- and cell type-specific anti-inflammatory immune modulation. Affected proteomic pathways regulating inflammation included JAK-STAT, NF-kappa B, and MAPK (p < 0.001). These findings were confirmed at the cellular level as the MAPK and JAK/STAT signaling responses were diminished and IkB, the negative regulator of NFkB, was elevated in adaptive immune cells.

Conclusion
Reported findings provide a first proof of principle in humans that a young plasma protein fraction actively regulates inflammatory and immune responses in an elderly population. They provide a solid rationale for elucidating active principles in young plasma that may be of therapeutic benefits for a range of age-related pathologies.

Trial registration
ClinicalTrials.gov, NCT 03981419.
Maraviroc enhances Bortezomib sensitivity in multiple myeloma by inhibiting M2 macrophage polarization via PI3K/AKT/RhoA signaling pathway in macrophages
Authors: Yang Huiye , He Yuchan , Qu Fujun , Zhu Jie , Deng Liyuan , Jiang Fang , Wu Xianyi , Chen Yixuan , Kashif Ali , Wang Xiaotao 
Published: February 2025

Abstract

Background
Multiple myeloma (MM) is a malignancy where drug resistance often leads to relapse or refractory disease. Chemokine receptor 5 (CCR5) has emerged as a novel therapeutic target. However, the role of CCR5-antagonist Maraviroc (MVC) in M2 macrophage polarization and its potential to enhance Bortezomib sensitivity in MM has not been fully explored.

Methods
We used human bone marrow samples, RPMI 8226 cells, and THP-1 monocytes to investigate CCL3/CCR5 axis. ELISA measured CCL3/CCR5 levels. Knockdown/overexpression vectors modulated expression. Cell proliferation, apoptosis, and macrophage polarization were assessed using CCK8, flow cytometry, and transwell assays. QRT-PCR analyzed CCL3 expression, and western blotting examined PI3K/AKT/RhoA signaling. CCR5 was targeted via siRNAs or MVC. NOD/SCID mouse model evaluated CCL3/CCR5 effects on macrophage polarization and MVC’s impact on Bortezomib efficacy.

Results
CCL3, CCR5, and M2 macrophage markers are upregulated in MM patients, with CCL3/CCR5 expression correlating with M2 macrophage polarization. Myeloma-secreted CCL3 and paracrine CCR5 significantly promoted M2 macrophage polarization by activating PI3K/AKT/RhoA signaling, which in turn enhanced myeloma proliferation, inhibited apoptosis, and reduced Bortezomib sensitivity. MVC inhibited M2 macrophage polarization and improved Bortezomib sensitivity in vitro and xenograft mouse myeloma models.

Conclusions
MVC reduced macrophage polarization and enhanced Bortezomib sensitivity in MM cells.
$q,\omega $-Tricomi expansions and exponential integral associated with Hahn difference operator
Authors: Oraby Karima M. 
Published: February 2025

Abstract
In this paper, we introduce a

$q,\omega $

q
,
ω

-analog of Tricomi expansion based on Hahn’s difference operator. Some properties of

$q,\omega $

q
,
ω

-Tricomi expansion are derived and proved in terms of incomplete

$q,\omega $

q
,
ω

-gamma functions. Also, a

$q,\omega $

q
,
ω

-analog of the exponential integral is presented as a series expansion of incomplete

$q,\omega $

q
,
ω

-gamma functions and shown to be a limiting case of a

$q,\omega $

q
,
ω

-Tricomi expansion.
Assessing the knowledge, attitudes, and practices (KAP) of dengue in Thailand: a systematic review and meta-analysis
Authors: Crowley Julia , Liu Bowen , Jan Hanan 
Published: February 2025

Abstract

Aim
Dengue cases are on the rise in Thailand, coinciding with increases in flooding events. Studies pertaining to public knowledge, attitudes, and practices (KAP) of dengue prevention have frequently been used to better understand the public’s needs towards dengue. While these studies were conducted in different settings, it is necessary to initiate a systematic review and meta-analysis of relevant studies.

Subjects and method
We conducted a systematic review and meta-analysis of prior studies in Thailand that assessed the KAP towards dengue. Eligibility criteria were established and independently used by reviewers to select nine studies for the systematic review and three for the meta-analysis. Collectively, the nine studies included 3,058 individuals and 2,519 households.

Results
The overall estimate of the proportion of participants with good knowledge of dengue prevention is 35% (95% CI: 14-59%), suggesting the majority of the population in Thailand had low levels of knowledge towards dengue. The poor levels of practice in Thailand were also observed and confirmed for the majority of the population by meta-analysis, with the pooled estimate of the proportion of participants with good practice of dengue prevention being 25% (95% CI: 22-27%). In contrast, most of the studies included in the systematic review reported positive attitudes towards dengue prevention, and this finding was also affirmed by the meta-analysis, as the pooled estimate of the proportion of positive attitudes towards dengue prevention is 61% (95% CI: 43-77%).

Conclusion
Despite good attitudes towards dengue prevention, poor knowledge and poor practices predominate, highlighting the need for enhanced public health campaigns to educate the public on dengue risks and prevention methods.
Empirical and numerical hill slope health evaluation at Malling Nala, NH-505, Himachal Pradesh, India
Authors: Azad Md Alquamar , Kainthola Ashutosh , Fissha Yewuhalashet , Kushwaha Gaurav , Yadav Vikas , Singh T. N. 
Published: February 2025

Abstract
Slope failures and rock mass movements are continuous geomorphic processes, particularly in a dynamically charged terrane like the Himalaya. Thus, failures emanating from weak geology, hydrogeology and anthropogenic disturbances are aplenty. Present research evaluates slope stability in the vicinity of Malling Nala, along NH-505 in Himachal Pradesh, India. For the two most vulnerable sections in the study area, geo-mechanical and structural attributes have initially been ascertained. Field surveys and laboratory tests identified weak and weathered mica schist and gneissic rocks in the study area. Kinematic analysis, Rock Mass Rating (RMR), Geological Strength Index (GSI), Slope Mass Rating (SMR), modified Global Slope Performance Index (mGSPI) led to determination of possible failure mechanism and rock mass behaviour. Finite element analysis provided a comprehensive understanding of slope behaviour under various conditions, highlighting significant shear strain and displacement in both sections. As noticed from the field and classification schemes, planar and localized bench failures were established. Slope section L-1 was found to collapse under saturated water condition, manifesting the influence of snow melt. The findings indicate that both natural and human factors are causing instability. Effective risk management and mitigation strategies are essential to maintain the stability and reliability of this critical frontier region.
Macrotroponin interference and association with cardiotoxicity in patients receiving cardiotoxic breast cancer therapy: a pilot study
Authors: Soosaipillai Andrea , Nardi-Agmon Inbar , Brinc Davor , Fabros Anselmo , Kavsak Peter A. , Thavendiranathan Paaladinesh , Di Meo Ashley 
Published: February 2025

Abstract

Background
Cancer therapy-related cardiac dysfunction (CTRCD) is an important adverse effect in patients receiving potential cardiotoxic cancer therapies. Interpretation of cardiac troponin results can be affected by presence of macrotroponin, which can complicate CTRCD assessment. We aimed to assess whether macrotroponin is detectable in women with ERBB2 + breast cancer receiving sequential therapy with anthracyclines and trastuzumab.

Methods
A total of 20 serum samples from 12 ERBB2 + breast cancer patients (median age: 55 years, range: 30–69 years) who exhibited a significant increase in high-sensitivity cardiac troponin I (hs-cTnI) from baseline to post-anthracycline (~ 2 months after therapy initiation) and/or 3-months into trastuzumab therapy (~ 5 months after therapy initiation) and/or who had at least one hs-cTnI value above the female-specific 99th percentile (hs-cTnI > 16 ng/L) and had available banked blood for analysis were included in this pilot study. Samples were analyzed using the Abbott STAT High-Sensitive Troponin-I and Roche Elecsys Troponin T hs STAT assays. Macrotroponin was detected by treating the sample with protein G and re-measuring hs-cTn. Macrotroponin presence was defined as a hs-cTnI or hs-cTnT recovery of < 40% or 85%, respectively.

Results
Macrotroponin was not identified after anthracycline treatment but was present in four patients 3-months into trastuzumab therapy, two of which had hs-cTnI concentrations above the 99th percentile. None of these patients exhibited a significant reduction in LVEF and/or GLS despite having significant elevations in hs-cTnI.

Conclusions
Clinicians should be cautious of benign hs-cTn elevations resulting from macrotroponin presence, as it can complicate CTRCD assessment.
Radiodiagnostic performance of canine morphology for sexual dimorphism in Brazilian adults — a cross-sectional study
Authors: Stibich Christian , Soares Mariana , Rossetto Carolina , Rangel-Coelho João Pedro , Boedi Rizky , Franco Ademir 
Published: February 2025

Abstract

Background
Sex estimation through dental features is an important contribution of forensic odontology for human identification. Permanent canines have been used to this end with disputable reliability across studies. The present study aimed to test the sexual dimorphism of permanent human canines using ratios of linear measurements performed in periapical radiographs of Brazilian adults. The sample consisted of 112 canine periapical radiographs. Three ratios of six linear measurements were established: (1) maximum crown length/maximum tooth length, (2) tooth width at the cementum-enamel junction/maximum crown width, and (3) thickness of the crown enamel/width of the crown dentin.

Results
Ratio 2 was statistically significant for the maxillary and mandibular canines, and ratio 3 was statistically significant for the mandibular canine (p < 0.05). Their accuracy was between 63 and 65%.

Conclusion
Canine sexual dimorphism was discrete and seems to be more associated with measurements of crown, dentin, and enamel width. Sex-related differences were more evident in the mandibular canine. Future radiodiagnostic use of the permanent human canines should be solely adjuvant and when no other traditional method is suitable.
Topological data analysis with digital microscope leather images for animal species classification
Authors: Ehiro Takuya , Onji Takeshi 
Published: February 2025

Abstract
This study presents a method for classifying cow and horse leather using a small number of digital microscope images and topological data analysis. In this method, hair pore coordinates in the images are used as essential information for classification. First, the coordinates were semiautomatically extracted using conventional image processing methods and persistent homology (PH) computation. Binary images with white pixels corresponding to the coordinates were generated, and their PHs were computed using filtration based on the Manhattan distance. In addition to the pairwise distance between the two pores, zeroth- and first-order lifetimes were used as explanatory variables to construct the classifier. Among the three explanatory variables, the zeroth-order lifetime resulted in the highest classification accuracy (86%) for the test data. Furthermore, we constructed logistic regression (LR) and random forest (RF) models using the zeroth-order lifetime computed from all images and conducted model interpretation. In both LR and RF, information on a zeroth-order lifetime of less than 10 was used as an important explanatory variable. Additionally, the inverse analysis of birth–death pairs suggested that the zeroth-order lifetime contains topological information distinct from the conventional pairwise distance. Our proposed method is designed to be robust in data-limited situations because it only uses hair pore coordinates as explanatory variables and does not require other information, such as hair pore density or pore size. This study demonstrates that accurate classifiers can be obtained using topological features related to hair pore arrangement.

Graphical Abstract
Methodologic Approach to Defining Comorbidities in a Cohort of Patients With Cancer: An Example in the Optimal Breast Cancer Chemotherapy Dosing Study
Authors: Wang Peng , O'Connell Kelli , Bhimani Jenna , Blinder Victoria , Burganowski Rachael , Ergas Isaac J. , Gallagher Grace B. , Griggs Jennifer J. , Heon Narre , Kolevska Tatjana , Kotsurovskyy Yuriy , Kroenke Candyce H. , Laurent Cecile A. , Liu Raymond , Nakata Kanichi G. , Persaud Sonia , Rivera Donna R. , Roh Janise M. , Tabatabai Sara , Valice Emily , Bandera Elisa V. , Kushi Lawrence H. , Aiello Bowles Erin J. , Kantor Elizabeth D. 
Published: February 2025

PURPOSE
We evaluated the definitions of five comorbidities (renal and hepatic impairments, anemia, neutropenia, and thrombocytopenia) in women with breast cancer using data from electronic health records.

METHODS

In 11,097 women receiving adjuvant chemotherapy for stage I-IIIA breast cancer at Kaiser Permanente Northern California or Kaiser Permanente Washington, we assessed comorbidity definitions in two commonly used lookback windows (1 year before diagnosis, T1; and extending until chemotherapy initiation, T1-2). Within each, we assessed data availability and agreement between International Classification of Diseases (ICD)–defined and lab-defined comorbidities of varying severity. To assess how different pieces of information may affect providers in making treatment decisions, we used multivariable logistic regression to evaluate four-category (with comorbidity indicated by both ICD and lab, ICD-only, lab-only, or neither) and collapsed binary (comorbidity indicated by either ICD or lab
v
neither) definitions in relation to first cycle chemotherapy dose reduction (FCDR).

RESULTS

Extending the lookback period to chemotherapy initiation increased laboratory data availability (missingness ≤4.1% in T1-2
v
>40% in T1). Assessment of agreement guided selection of laboratory cutpoints. In both time periods, the four-category and binary comorbidity variables were associated with use of FCDR, but binary variables had larger cell sizes and more stability of regression models. Ultimately, the comorbidity variables in T1 were defined by a combination of either ICD/qualifying laboratory values. Results were similar in T1-2, except laboratory data alone outperformed the combination variable for renal and hepatic comorbidity.

CONCLUSION
Leveraging both ICD and lab data and extending the lookback period to include postdiagnosis but prechemotherapy initiation may provide better capture of comorbidity. Future studies may consider validating our findings with a gold-standard comorbidity status and in other community health care settings.
Real-World Patient-Reported Outcome Measure Implementation: Challenges and Successes of a Pan-Canadian Initiative to Improve the Future of Patient-Centered Cancer Care
Authors: Lambert Sylvie , McKenzie Michael , Coronado Andrea C. , Caissie Amanda , Tracey Linda , Watson Linda , Deiure Andrea , Shaw-Moxam Raquel , Ryan Jean Ann , Arab Marianne , Jorgensen Bryan , Crump Ashley , Rayner Lisa , Lecours Mireille , Howatt Peter Shaw 
Published: February 2025

PURPOSE
Implementation of patient-reported outcome measures (PROMs) in routine care continues to be limited, despite their demonstrated efficacy and substantial investments. We report on the lessons learned and the challenges of the concerted implementation of the same PROMs across teams in nine provinces/territories (jurisdictions) in Canada, as well as the solutions to move implementation forward despite cost containments and the COVID-19 pandemic.

METHODS
Each team from nine jurisdictions submitted a final report describing their PROM implementation project. Reports were analyzed for themes on lessons learned, challenges, and solutions. Themes were compared for similarities and differences. The Standards for Quality Improvement Reporting Excellence (SQUIRE) guidelines were used.

RESULTS
Six key lessons learned were identified from eight challenges. To address these challenges, 27 solutions were used. The six lessons learned were as follows: Harness the power of change management, ensure consistent stakeholder engagement at all levels for success, establish buy-in as soon as possible, plan to maintain buy-in through changing circumstances, identify ways to make technology the solution, and optimal implementation includes a sustainability plan. Examples of solutions included the following: develop a multipronged, multilevel communication plan; include change management experts on the team; identify champions; restructure and reprioritize as needed; leverage existing technology; and leave a permanent trace of the project.

CONCLUSION
To our knowledge, this is the first analysis to synthesize lessons learned from real-world PROM implementation across geographically diverse jurisdictions. We identified generalizable solutions that other health care managers and policymakers can use to accelerate PROM implementation, despite pervasive implementation barriers. Future studies can integrate these solutions with methods and tools from implementation science (eg, theoretical frameworks, implementation strategies) for more successful spread and scale of PROMs.