bluuebunny/crossref_metadata_2025_split huggingface dataset:
GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy
Authors: Wang Zaozao , Jiang Beihai , Chen Lei , Di Jiabo , Cui Ming , Liu Maoxing , Ma Yiyuan , Yang Hong , Xing Jiadi , Zhang Chenghai , Yao Zhendan , Zhang Nan , Dong Bin , Ji Jiafu , Su Xiangqian 
Published: January 2014

Abstract

Background
Golgi phosphoprotein 3 (GOLPH3) has been validated as a potent oncogene involved in the progression of many types of solid tumors, and its overexpression is associated with poor clinical outcome in many cancers. However, it is still unknown the association of GOLPH3 expression with the prognosis of colorectal cancer (CRC) patients who received 5-fluorouracil (5-FU)-based adjuvant chemotherapy.

Methods
The expression of GOLPH3 was determined by qRT-PCR and immunohistochemistry in colorectal tissues from CRC patients treated with 5-FU based adjuvant chemotherapy after surgery. The association of GOLPH3 with clinicopathologic features and prognosis was analysed. The effects of GOLPH3 on 5-FU sensitivity were examined in CRC cell lines.

Results
GOLPH3 expression was elevated in CRC tissues compared with matched adjacent noncancerous tissues. Kaplan-Meier survival curves indicated that high GOLPH3 expression was significantly associated with prolonged disease-free survival (DFS, P = 0.002) and overall survival (OS, P = 0.011) in patients who received 5-FU-based adjuvant chemotherapy. Moreover, multivariate analysis showed that GOLPH3 expression was an independent prognostic factor for DFS in CRC patients treated with 5-FU-based chemotherapy (HR, 0.468; 95%CI, 0.222-0.987; P = 0.046). In vitro, overexpression of GOLPH3 facilitated the 5-FU chemosensitivity in CRC cells; while siRNA-mediated knockdown of GOLPH3 reduced the sensitivity of CRC cells to 5-FU-induced apoptosis.

Conclusions
Our results suggest that GOLPH3 is associated with prognosis in CRC patients treated with postoperative 5-FU-based adjuvant chemotherapy, and may serve as a potential indicator to predict 5-FU chemosensitivity.
Association between Common Genetic Variants in the Opioid Pathway and Smoking Behaviors in Chinese Men
Authors: Fang Juan , Wang Xiaohong , He Bei 
Published: January 2014

Abstract

Background
There is biological evidence that the brain opioidergic system plays a critical role in the addictive properties of nicotine. The purpose of the present study was to examine the associations of single nucleotide polymorphisms (SNPs) in the genes encoding mu-opioid receptor (MOR) and the MOR-interacting proteins (including OPRM1, ARRB2, and HINT1) with smoking behaviors in Chinese men.

Methods
A total of 284 subjects (including current and ex-smokers) were recruited. Special questionnaires were used to assess smoking behaviors including age of smoking initiation, daily cigarette consumption, and Fagerström test for nicotine dependence (FTND) score. Participant samples were genotyped for six SNPs in the opioid pathway genes: rs1799971 in OPRM1, rs1045280, rs2036657 and rs3786047 in ARRB2, rs3852209 and rs2278060 in HINT1. Linear and logistic regression models were used to determine single-locus and haplotype-based association analyses.

Results
There was no significant association between any of SNPs analyzed and smoking behaviors. Logistic regression analyses under dominant, recessive, and additive models showed no significant associations of the six SNPs with smoking status (current vs. ex-smokers). After adjustment for age at enrollment and smoking initiation age, HINT1 rs3852209 was significantly associated with smoking status with an OR of 0.54 (95% CI, 0.31-0.95; P = 0.03) under dominant inheritance model. No haplotypes in ARRB2 or HINT1 were related to smoking status.

Conclusions
The present study indicates no significant association between common genetic variations in MOR and MOR-interacting proteins and smoking behaviors in Chinese men, and gives suggestive evidence that HINT1 rs3852209 may be related to smoking status. The findings require confirmation from further studies in additional larger samples.
Expression of serum amyloid A in uterine cervical cancer
Authors: Ren Yanjie , Wang He , Lu Donghao , Xie Xiaoyan , Chen Xinlian , Peng Jing , Hu Qian , Shi Gang , Liu Shanling 
Published: January 2014

AbstractBackgroundAs an acute-phase protein, serum amyloid A (SAA) is expressed primarily in the liver. However, its expression in extrahepatic tissues, especially in tumor tissues, was also demonstrated recently. In our study, we investigated the expression of SAA in uterine cervical carcinomas, and our results suggested its potential as a serum biomarker.MethodsQuantitative real-time polymerase chain reaction (RT-PCR), immunohistochemistry (IHC) and enzyme-linked immunosorbent assay (ELISA) were used to evaluate the SAA gene and protein expression levels in the tissues and sera of patients with non-neoplastic lesions (NNLs), cervical intraepithelial neoplasia (CIN) and cervical carcinoma (CC).ResultsCompared with NNLs, the SAA gene (SAA1andSAA4) expression levels were significantly higher in uterine CC (mean copy numbers: 138.7 vs. 5.01, P < 0.000; and 1.8 vs. 0.079, P = 0.001, respectively) by real-time PCR. IHC revealed cytoplasmic SAA protein staining in tissues from adenocarcinoma and squamous cell carcinoma of the cervix. The median serum concentrations (μg/ml) of SAA were 6.02 in patients with NNLs and 10.98 in patients with CIN (P = 0.31). In contrast, the median serum SAA concentration was 23.7 μg/ml in uterine CC patients, which was significantly higher than the SAA concentrations of the NNL group (P = 0.002) and the CIN group (P = 0.024).ConclusionsOur data suggested that SAA might be a uterine CC cell product. High SAA concentrations in the serum of CC patients may have a role in monitoring disease occurrence and could have therapeutic applications.Virtual slidesThe virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1433263219102962
Effect of pumpkin on the quality characteristics and storage quality of aerobically packaged chicken sausages
Authors: Zargar Fayaz Ahmed , Kumar Sunil , Bhat Zuhaib Fayaz , Kumar Pavan 
Published: January 2014

Abstract
The present study was undertaken to evaluate the effect of different levels of pumpkin on the quality characteristics of chicken sausages. The pumpkin was incorporated at three different levels viz. 6, 12 and 18 percent replacing lean meat in the formulation. The products were analyzed for various physicochemical and sensory attributes. pH, emulsion stability, cooking yield, crude protein, ether extract and ash content of the products showed significantly (p < 0.05) decreasing trend with increasing levels of incorporation of pumpkin however, there was a significant (p < 0.05) increase in the moisture and crude fibre content. Based on various parameters, 12 percent level of incorporation was optimized as best. Chicken sausages with optimum level of pumpkin along with control were aerobically packaged in LDPE pouches and assessed for storage quality under refrigerated (4 ± 1°C) conditions. The mean values of pH and all the sensory parameters showed significantly (p < 0.05) decreasing trend for both control as well as treatment samples whereas TBARS (mg malonaldehyde/kg) value, total plate count (log cfu/g) and yeast and mould count (log cfu/g) showed significantly (p < 0.05) increasing trend with storage. Coliforms (log cfu/g) were not detected throughout the period of storage. Thus, fibre enriched chicken sausages could be successfully stored for a period of 14 days at refrigeration temperature (4 ± 1°C) without any significant loss in quality.
Preparation of Nanoporous Inorganic–Organic Hybrids Containing Zirconium and Asymmetrically Linking O3P–C6H4–SiO3 Unit
Authors: Maeda Kazuyuki , Otsu Masato , Kobayashi Hiroki , Kondo Atsushi 
Published: January 2014

Abstract
Inorganic–organic hybrid materials composed of [O3P–C6H4–SiO3] units and zirconium hydrothermally prepared in the presence of cationic surfactant showed nanoporosity and considerably high specific surface area.
MULTIPURPOSE HUMAN MEASURING. PART II
Authors: Леонтьев  , Leontev Boris 
Published: January 2014

The most critical human mission in any country should be carried out as
a result of personality’s preliminary selection. Any target human selection
and rating are not only within the particular area of science, such as the
psychology, sociology, economics or law. Rating and assessment should
be integrated and complex. Each indicators criteria of the human resource
capacity, capital and factors should be measurable and they should be
also known to the individual. Open, massive, widespread and mandatory
human dimensions characterize the level of civilization of the relationship
in any modern state. In order to improve the economy the designee
for high and responsible positions should be more sober evaluated and
therefore, first of all, it is important to take into account what is really
done by this individual as the author and ideologist of given direction.
The author of given publication offers the comprehensive methodology
for human quality categories assessment and rating.
STATE SOCIAL POLICY FOR YOUTH: ODELS, CLASSIFICATION, ACTUAL PROBLEMS
Authors: Лукьянова  , Lukyanova Tatyana , Ловчева  , Lovcheva Marina , Кибанов  , Kibanov Ardalon 
Published: January 2014

Activity of the state plays the major function in development and realization
of youth policy of Russia, it is directed on creation of legal, economic
and organizational conditions and guarantees for self-realization
of the identity of the young man and development of youth associations,
movements and initiatives. The most important means of involvement
of youth in political life and the social and labor relations is formation of
system of ideas and the principles concerning a place and a role of young
generation in the society, making base for effective joint practical activities
of the state, employers, public organizations and other social institutes
on realization of these ideas and provisions for formation and development
of youth, realization of its creative potentialities in interests of society. In
article problems of distribution of responsibility between the state,
business and noncommercial sector are considered at realization of youth
policy of Russia and other countries.
Practical aspects of knowledge management in learning organization
Authors: Коробкина  , Korobkina M. 
Published: January 2014

The article deals with urgent problems of knowledge management in
learning organizations; discusses the practical aspect of the company,
based on knowledge; investigates the problems and prospects of learning
organizations. The article aims to identify the mechanisms of corporate
knowledge management in the learning organization. The author
considers knowledge as a result of mental activity, there is a «people´s
minds». Considered formalized and tacit knowledge, as true learning
organization. Additionally, the article provides practical advice for learning
organizations, developing the knowledge management function. The
function of knowledge management is seen as an essential component
of organizational learning. In conclusion, disclosed the problems and
prospects of learning organizations, as well as considering the prospect
of becoming a learning organization. The article is based on an analysis
of the Russian and foreign experience.
ETHICAL PROBLEMS OF MODERN BUSINESS AND PERSONNEL MANAGEMENT
Authors: Миргеева  , Mirgeeva V. 
Published: January 2014

The fear expresses, that norms of morals and morals in modern cjnditions
of the Russian society as a whole? And the business world in particular,
are strongly dim. The concept “intelligence” not in a fashion and its disappearance
looks today as natural process. The question on necessity of
increase of business culture of the manager – manager rises, lack or which
absence sooner or later will be wrapped up by economic losses, and
further – crisis.
Difficult to consider an ethics role in the sphere of the economic relations
because of their nature based on utilitarian interest which absence
inevitably results in stagnation, degradation of economy and as a result
to fall of a standard of living of the population. Economy operate not
only economic laws. It is impossible to ignore a human factor that means
impossibility of an exception of freedom of a moral choice from economic
processes. Therefore, the moral principles too are economic
factor since rules of the free market are based that people adhere to
the general moral and ethical reference points in the course of labor
activity.
State Policies and Practices in Behavior Supports for Persons With Intellectual and Developmental Disabilities in the United States: A National Survey
Authors: Rotholz David A. , Moseley Charles R. , Carlson Kinsey B. 
Published: January 2014

Abstract
Providing effective behavioral supports to decrease challenging behavior and replace it with appropriate alternative skills is essential to meeting the needs of many individuals with intellectual and developmental disabilities (IDD). It is also necessary for fulfilling the requirements of Medicaid-funded individual support plans and is important for moral, ethical, and societal reasons. Unfortunately, there is no national standard for behavioral support practices or source of information on the status of behavior support policies, practices, and services for adults with IDD at either state or national levels. The collection of comprehensive data on state behavior support definitions, provider qualifications, training, and oversight requirements is a necessary starting point for the development of plans to address needed policy and practice changes. This survey is the first national assessment of state policies and practices regarding the definition and delivery of behavior support services to people with intellectual and developmental disabilities receiving publicly financed supports in the United States.
Teaching Students With Disabilities Efficacy Scale: Development and Validation
Authors: Dawson Heather , Scott LaRon 
Published: January 2014

Abstract
Promoting access to inclusive environments for students with disabilities is a critical issue facing schools. Feeling efficacious in teaching students with disabilities is a key aspect of enabling teachers to promote inclusion. This article reports on the development of a scale of teacher self-efficacy for teaching students with disabilities. It was examined with in-service (N = 288) and preservice (N = 143) teachers, and the results suggest it is a reliable and valid tool. The final version includes five subscales that define efficacy for teaching students with disabilities, all with strong statistical reliability and compelling conceptual meaning. They are: Instruction, Teacher Professionalism, Teacher Support, Classroom or Behavior Management, and Related Duties. Implications for future research and practice are discussed.
The Effect of “Measurable and Rigorous” State Performance Goals for Addressing “Free and Appropriate Public Education Within the Least Restrictive Environment”
Authors: Marks Susan , Kurth Jennifer , Pirtle Jody 
Published: January 2014

Abstract
Sections 616 and 642 of the 2004 Individuals with Disabilities Education Act (IDEA) required states to develop a State Performance Plan (SPP) to (a) evaluate their efforts in implementing the requirements of IDEA and (b) describe their plan for implementation of IDEA through determination of “measurable and rigorous” goals. In this article, we examine the performance targets proposed by states within the Southwest region of the United States to examine the impact that SPP targets have had on actual changes in practice focused on Indicator 5. Indicator 5 focuses on increasing the provision of special education services in the least restrictive environment (LRE). Our analysis found that actual changes on LRE measures were unaffected by SPP targets.
Invariant surfaces in Sol3 with constant mean curvature and their computer graphics
Authors: López Rafael 
Published: January 2014

Abstract
In Sol3 space there are three uniparametric groups of isometries. In this work we study constant mean curvature surfaces invariant by one of these groups. We analyze the geometric properties of these surfaces by means of their computer graphics. We construct explicit examples of minimal surfaces and we shall relate them with recent examples of spheres with constant mean curvature.
On successive radii of p-sums of convex bodies
Authors: González Bernardo , Hernández Cifre María A. 
Published: January 2014

Abstract
We study the behavior of the successive inner and outer radii with respect to the Firey p-sums of convex bodies, where p ≥ 1. For all p ≥ 1 we get upper and lower bounds for the radii of the p-sum of two convex bodies in terms of the radii of the sets. These results generalize the corresponding relations for the classical Minkowski addition.
Scalar and Ricci curvatures of special contact slant submanifolds in Sasakian space forms
Authors: Mihai Adela , Rădulescu Ioana N. 
Published: January 2014

Abstract
In this paper we prove a Chen inequality involving the scalar curvature and a Chen-Ricci inequality for special contact slant submanifolds of Sasakian space forms, as the contact versions of the inequalities obtained by the first author in [15] and by both authors in [17], respectively.
Non-factorial quartic double solids
Authors: Hong Kyusik 
Published: January 2014

Abstract
We study the factoriality of a double cover X4 of ℙ
3 ramified along a nodal quartic surface, and we formulate a natural conjecture which would answer this problem depending on the number r, 8 ≤ r ≤ 10, of nodes of X4. We prove this conjecture when there is a nonsingular quadric surface containing all the nodes of X4.
Characterization of isometric embeddings of Grassmann graphs
Authors: Pankov Mark 
Published: January 2014

Abstract
Let V be an n-dimensional left vector space over a division ring R. We write Gk(V ) for the Grassmannian formed by k-dimensional subspaces of V and denote by Γk(V ) the associated Grassmann graph. Let also V′ be an n0-dimensional left vector space over a division ring R0. Isometric embeddings of Γk(V ) in Γk′(V′) are classified in [13]. A classification of J(n; k)-subsets in Gk′(V′), i.e. the images of isometric embeddings of the Johnson graph J(n; k) in Γk′(V′), is presented in [12]. We characterize isometric embeddings of Γk(V ) in Γk′(V′) as mappings which transfer apartments of Gk(V) to J(n; k)-subsets of Gk′(V′). This is a generalization of the earlier result concerning apartment preserving mappings [11, Theorem 3.10].
Collineation groups of topological parallelisms
Authors: Betten Dieter , Riesinger Rolf 
Published: January 2014

Abstract
Let P be a topological parallelism of the real projective 3-space PG3ℝ. We investigate the group AutP of all collineations of PG3ℝ leaving P invariant. We prove that AutP is a Lie group whose dimension is at most 6. The main result of the article says: if the dimension equals 6, then P is a Clifford parallelism. Furthermore, we show that there are no topological parallelisms in PG3ℝ with a 5-dimensional group.
Minimalphasigkeit – keine relevante Eigenschaft für die Regelungstechnik!
Authors: Zeitz Michael 
Published: January 2014

Zusammenfassung
Ursprünglich wurde die Minimalphasigkeit von H. W. Bode
eingeführt, um den eineindeutigen Zusammenhang zwischen Amplitude
und Phase des Frequenzgangs zu definieren. Beim Entwurf von
digitalen Filtern wird eine andere Definition der
Minimalphasigkeit verwendet und ein asymptotisch stabiles Filter
als minimalphasig bezeichnet, wenn auch das inverse Filter
asymptotisch stabil ist. Schließlich werden von C. I. Byrnes und
A. Isidori Systeme mit einer asymptotisch stabilen Nulldynamik als
minimalphasig bezeichnet. Wegen der nicht konsistenten
Definitionen wird dafür plädiert, den Minimalphasigkeits-Begriff
in der Regelungstechnik zu vermeiden und die Stabilität von
Filtern und der Nulldynamik mit den wohl definierten Kriterien von
Hurwitz oder Ljapunow zu beschreiben.
Personalentwicklung in wissenschaftlichen Bibliotheken
Authors: Kibler Simone 
Published: January 2014

Zusammenfassung:Die Vermittlung von Informationskompetenz spielt in wissenschaftlichen Bibliotheken eine zunehmend große Rolle. In der Universitätsbibliothek (UB) Braunschweig ist Informationskompetenz zu einem festen Bestandteil des Studienfaches Biologie geworden. Somit sind Bibliothekarinnen und Bibliothekare gefragt, einen Beitrag zu akademischer Lehre zu leisten. Doch welche Anforderungen birgt dies genau und wie werden Bibliothekarinnen und Bibliothekare auf diese anspruchsvolle Aufgabe vorbereitet? Dieser Frage wird im folgenden Artikel anhand des Beispiels der UB Braunschweig nachgegangen.
Cognitive Type and Visual Metaphorical Expression
Authors: Niño Douglas , Serventi Germán 
Published: January 2014

Abstract
The purpose of this paper is, first, to present a systematic cognitive type theory, which we believe can provide a better explanation of the semantic work of iconic signs than the iconic type theory proposed by Groupe μ (1992). The second objective is to present Conceptual Metaphor Theory (CMT) and to show its limitations in accounting for visual metaphoric phenomena. We suggest those constraints can be corrected with the cognitive type model. At the end, we attempt to illustrate how the cognitive type notion can explain visual metaphoric phenomena, taking into account the main aspects of CMT.
Bionanocomposites with enhanced antimicrobial activity and photodegradability based on low density polyethylene and nano TiO2/organoclay
Authors: Katbab Pouya , Alizadeh Maryam , Kaffashi Babak , Katbab Ali Asghar 
Published: January 2014

AbstractBionanocomposite materials with enhanced photodegradability and bactericidal activity, as well as improved gas barrier properties, were manufactured by incorporating silicate nanolayers into the structure of low density polyethylene (LDPE) filled with nano titanium dioxide (TiO2) via melt compounding. Effects of interfacial compatibilization upon developed microstructure were studied by incorporating maleated LDPE into the nanocomposites formulation. Field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and rheo-mechanical spectroscopy (RMS) techniques were conducted to characterize the microstructure of the nanocomposites. Interfacially compatibilized TiO2/organoclay (OC) based nanocomposites exhibited shorter induction time for the onset of photodegradation, and an acceptable inactivation of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) microbe cells upon UV light irradiation, indicating enhanced photoactivity of the hybridized TiO2/OC nanosystem. TiO2/OC-based nanocomposites exhibited increased melt viscosity and pseudo solid like characteristics in melt linear viscoelastic behavior. Moreover, TiO2/OC-based nanocomposites presented improved barrier properties, which make such materials applicable for packaging applications.
Constrained swelling and instability of a temperature-sensitive hydrogel ring
Authors: Li Meie , Geng Jiasong , Zhou Jinxiong 
Published: January 2014

AbstractWe analyze the constrained swelling of a temperature-sensitive hydrogel ring, a key component of a previously developed adaptive liquid microlens. Hard constraints make the deformation and stress distribution within the gel nonuniform. The compressive stress may even cause the instability of the ring. We code a material model for poly(N-isopropylacrylamide) hydrogel and predict wrinkling instability at the inner periphery of the ring by using a commercial finite element method software. The presented model and the codes can be utilized to aid the design of soft devices based on temperature-sensitive hydrogels.