bluuebunny/crossref_metadata_2025_split huggingface dataset:
„Na granicy Zachodu i Wschodu”
Authors: Osadczy Włodzimierz 
Published: July 2013

Володимир Осадчий, „На межі Сходу і Заходу”. Значення Почаївського монастиря в імперіальній політиці Росії
Почаїський монастир на Волині був одним з найзнаменитіших сакральних центрів цілого регіону. Початки марійного культу на цих землях сягали ХІІІ ст. Однак свій найбільший розквіт монастир переживає в уніатський період, наприкінці існування Речі Посполитої. У цей час зводяться величні споруди монастирського комплексу, відбуваються знамениті релігійні урочистості. Після придушення польського повстання 1831 р. монастир замінюють на православний русифікаторський центр, спрямований також на закордонне населення Галичини. Крім релігійного призначення він провадив політичну діяльність, що відповідала геополітичним російським планом «воззєднати» всі руські землі. Розмір цієї діяльності ще раз підкреслює підпорядкування релігії політичним цілям у Російській імперії. З іншої сторони «почаївські прощі» показали вплив російської політики на уніатське галицьке населення.
La Monja de Lisboa en un manuscrito anónimo de la “colección berlinesa” depositada en la Biblioteca Jaguelónica de Cracovia
Authors: Rzepka Anna 
Published: July 2013

Maria de la Visitación - portugalska zakonnica, bohaterka anonimowego hiszpańskiego manuskryptu ze zbiorów tzw. „kolekcji berlińskiej” Biblioteki Jagiellońskiej
Artykuł nawiązuje do postaci portugalskiej zakonnicy Marii de la Visitación (1551-ok. 1603), która zyskała rozgłos wśród współczesnych dzięki pseudomistycznym doświadczeniom. Obok wymiaru religijnego, historia zakonnicy wpisuje się także w klimat napięć politycznych między Hiszpanią i Portugalią w początkowym okresie Unii Iberyjskiej (1580-1640), kiedy to oba sąsiadujące ze sobą królestwa połączono pod wspólnym berłem hiszpańskiego monarchy Filipa II. Artykuł powstał w oparciu o anonimowy rękopis hiszpański należący do tzw. kolekcji berlińskiej, pochodzącej z dawnej Pruskiej Biblioteki Państwowej w Berlinie (Preussische Staatsbibliothek zu Berlin), zdeponowanej obecnie w Bibliotece Jagiellońskiej w Krakowie.
Diagnostic Value of Distinguishing and Reporting Different Perinuclear ANCA (P-ANCA) Immunofluorescence Patterns
Authors: Perel Susan B. , Prain Kerri M. , Wilson Robert J. , Hogan Patrick G. , Gillis David , Wong Richard C. W. 
Published: July 2013

Abstract

Objectives:
To investigate whether discriminating the classic perinuclear antineutrophil cytoplasmic antibody (P-ANCA) pattern from atypical P-ANCA and uninterpretable patterns improves the diagnostic utility of ANCA testing.

Methods:
All ANCA requests (n = 3,544) referred to Pathology Queensland were analyzed prospectively over 4 months for P-ANCA pattern subtypes and myeloperoxidase (MPO)-ANCA/PR3-ANCA results and correlated with clinical, laboratory, and radiologic evidence of necrotizing small vessel vasculitis.

Results:
Of the 436 perinuclear immunofluorescence-positive samples, 45 were classic P-ANCA, 163 were atypical P-ANCA, and 228 were antinuclear antibodies/uninterpretable. The classic P-ANCA pattern had a significantly stronger association with vasculitis (30/45) than atypical P-ANCA (2/163) (P &lt;.0001) or ANA/uninterpretable patterns (8/228) (P &lt;.0001). The combination of a classic P-ANCA pattern and positive MPO-ANCA/PR3-ANCA result was also more strongly associated with vasculitis than a positive MPO-ANCA/PR3-ANCA result in isolation (P = .003).

Conclusions:
This study demonstrates that reporting different P-ANCA patterns (including ANA/uninterpretable patterns) provides additional diagnostic information to MPO-ANCA/PR3-ANCA results.
Correlation Between Dysplastic Lineage and Type of Cytopenia in Myelodysplastic Syndromes Patients With Refractory Anemia According to the FAB Classification
Authors: Matsuda Akira , Jinnai Itsuro , Iwanaga Masako , Okamura Daisuke , Ishikawa Maho , Maeda Tomoya , Hata Tomoko , Kawai Nobutaka , Miyazaki Yasushi , Bessho Masami , Tomonaga Masao 
Published: July 2013

Abstract

Objectives:
To analyze the correlation between dysplastic lineage and type of cytopenia in myelodysplastic syndromes.

Methods:
We analyzed the correlation between dysplasia and cell count using the data set of our previous morphologic study.

Results:
There were no correlations between dysgranulopoiesis of 10% or more and absolute neutrophil count (ANC). Similarly, hyposegmented mature neutrophils (Pelger) of 10% or more were not related to ANC. Interestingly, the platelet count of patients with dysmegakaryopoiesis (dys Mgk) was higher than that of patients without dys Mgk (dys Mgk ≥10% vs &lt;10%, P = .08; dys Mgk ≥40% vs &lt;40%, P = .02; micromegakaryocytes ≥10% vs &lt;10%, P = .004).

Conclusions:
Since low cell counts did not correlate with the presence of dysplastic features, we suggest that dysplastic features do not directly relate to apoptosis.
Utility of DNA Sequencing for Direct Identification of Invasive Fungi From Fresh and Formalin-Fixed Specimens
Authors: Moncada Pablo A. , Budvytiene Indre , Ho Dora Y. , Deresinski Stanley C. , Montoya Jose G. , Banaei Niaz 
Published: July 2013

Abstract

Objectives:
To describe and discuss the utility and potential pitfalls of ribosomal RNA locus sequencing for direct identification of invasive fungi from fresh and formalin-fixed, paraffin-embedded specimens.

Methods:
DNA was extracted from fresh and formalin-fixed, paraffin-embedded tissue and subjected to real-time polymerase chain reaction (PCR) targeting ITS2 and D2 regions of fungal ribosomal RNA locus. Cycle sequencing was performed on PCR products, and the identity of sequences was determined using a public database.

Results:
Four clinical cases of invasive fungal infection are presented to illustrate the utility of DNA sequencing for determining etiology when microbiological culture is negative, for shortening the time to identification of slow-growing fungi, for guiding antifungal therapy, and for shedding light on the pathogenesis of disseminated fungal infection.

Conclusions:
Fungal ribosomal RNA locus sequencing from fresh or formalin-fixed, paraffin-embedded specimens is a powerful tool for rapid and accurate diagnosis of patients with culture-negative or uncultured invasive mycosis.
Fresh and Citrated Whole-Blood Specimens Can Produce Different Thromboelastography Results in Patients on Extracorporeal Membrane Oxygenation
Authors: Gilman Elizabeth A. , Koch Christopher D. , Santrach Paula J. , Schears Gregory J. , Karon Brad S. 
Published: July 2013

Abstract

Objectives:
To compare thromboelastography (TEG) tracings obtained from fresh and citrated whole-blood samples in patients on extracorporeal membrane oxygenation (ECMO) or after cardiopulmonary bypass and in healthy volunteers.

Methods:
Samples of fresh and citrated whole blood were analyzed for 25 patients and 4 healthy volunteers. Thromboelastography analysis was performed in both plain and heparinase cups.

Results:
In 5 of 6 patients on ECMO, use of citrated samples resulted in apparent partial or complete heparin reversal. In TEG tracings from patients following cardiopulmonary bypass, there was a slight hypercoagulable appearance in the citrated sample. No differences were noted between fresh and citrated samples from healthy volunteers whose blood was spiked with heparin.

Conclusions:
In some patients on ECMO, use of samples collected in sodium citrate tubes for TEG analysis results in significant artifacts, which could lead to heparin overdosing in these patients.
Evaluation of enzymatic BM Test HbA1con the JCA-BM6010/C and comparison with Bio-Rad Variant II Turbo, Tosoh HLC 723 G8, and AutoLab immunoturbidimetry assay
Authors: Lee Jehoon , Kim Myungshin , Chae Hyojin , Kim Yeongsic , Park Hae-il , Kim Yonggoo , Chi Hyunyoung , Kwon Hi Jeong 
Published: July 2013

AbstractBackground: A novel enzymatic HbA1cassay was introduced for use in an automated chemistry analyzer. With this unique method, HbA1cand plasma glucose can be measured from the same EDTA tube. We evaluated the analytical performance of this enzymatic HbA1cassay in a JCA-BM6010/C analyzer and compared the HbA1cvalues with the results from other widely used methodological instruments.Methods: The imprecision, linearity, carry-over and concordance rate of the enzymatic HbA1ctest (BM Test HbA1c) using the JCA-BM6010/C analyzer were evaluated. Three hundred and seventy-seven specimens with HbA1cconcentrations from 16 to 133 mmol/mol were used for a comparison study with two high performance liquid chromatography methods: Variant II Turbo and Tosoh HLC 723 G8 and the AutoLab Hemoglobin A1cimmunoturbidimetry reagent using a Hitachi 7600-110. Forty specimens were used for the glucose method comparison.Results: The HbA1ccoefficients of variation of the within-run imprecision for low and high levels were 0.6% and 0.4%, respectively. The linearity of the BM Test HbA1cusing the JCA-BM6010/C analyzer was excellent in the range between 31 mmol/mol and 143 mmol/mol. The carry-over rate was 0.2%. The relationships between the BM test and the other three methods were 0.916×Tosoh G8+3.644, r=0.986; 0.887×Bio-Rad Variant II+1.896, r=0.972; and 0.941×AutoLab+4.532, r=0.977. The concordance rates using a cut-off of 48 mmol/mol were 91.5% with Tosoh G8, 82.8% with Bio-Rad Variant II, and 91.0% with AutoLab. The simultaneously assayed plasma glucose with HbA1cwas 1.002×Routine plasma glucose+0.625, r=1.000Conclusions: The enzymatic BM Test HbA1cin the JCA-BM6010/C analyzer showed excellent precision and linearity, and a minimal carry-over rate. The simultaneously assayed plasma glucose analysis showed good performance.
Do we really need high-sensitivity troponin immunoassays in the emergency department? Maybe not
Authors: Lippi Giuseppe , Cervellin Gianfranco 
Published: July 2013

AbstractThe diagnosis of acute coronary syndrome (ACS) has challenged the minds of cardiologists, emergency physicians and laboratorists for decades. A major breakthrough has, however, occurred at the dawn of the third millennium, with development, commercialization and introduction into clinical practice of troponin immunoassays. A novel generation of these methods, conventionally defined as “high-sensitivity” (HS), has more recently emerged. These latest generation assays are characterized by improved analytical sensitivity, which would theoretically allow earlier and more efficient diagnosis of ACS. Despite the considerable amount of information gathered over the past few years about the clinical use of conventional and HS immunoassays, several doubts persist and – according to our personal perspective – the evidence that the latest generation methods would represent a real breakthrough in management of patients in short-stay units such as the emergency department is still an unresolved issue. Beside the mystifying nomenclature that characterizes several commercial tests, recent evidence suggests that the diagnostic performance of some contemporary sensitive methods would equal those of HS immunoassays for early diagnosis, serial assessment and even prognostication of patients. Conversely, the better diagnostic specificity of conventional methods may represent an advantage for triaging patients in overcrowded emergency departments. There is hence a tangible threat that the measurement of troponin with HS methods would become more or less an “expensive cholesterol of the third millennium”, and this risk must be carefully considered in a world of limited resources. So, our answer to the question if we do really need HS troponin immunoassays in the emergency department is “maybe not”.
Warum brauchen wir Biodiversitätsforschung?
Authors: Wägele Johann-Wolfgang , Moenikes-Peis Ruth 
Published: July 2013

Abstract
Die aktuelle, durch den Menschen verursachte Biodiversitätskrise droht die wertvollsten erneuerbaren Ressourcen unseres Planeten zu vernichten. Der zerstörerische Effekt einer wachsenden Weltbevölkerung ist hinreichend nachgewiesen. In den kommenden Jahrzehnten werden wir Zeugen des Aussterbens einer großen Zahl von Tier- und Pflanzenarten sein. Legt man vergleichbare Phasen der Erdgeschichte zugrunde, in denen es zu Massenaussterben kam, so zeigt sich, dass die Dauer einer Regeneration von Biodiversität die für den Menschen vorstellbare Zeitspanne bei weitem überschreitet. Während die meisten Menschen gut über die Klimaerwärmung informiert sind, sind vielen die Veränderungen in der Biosphäre nicht bewusst. Im Gegensatz zur Klimaforschung gibt es hier bislang keine groß angelegten Monitoringprogramme und es besteht noch Entwicklungsbedarf für Methoden zur schnellen Erfassung der Artenvielfalt. Die Taxonomen, d. h. die Wissenschaftler, die Arten kennen und klassifizieren, brauchen umfassendere Unterstützung.
Naturethik und Biodiversität
Authors: Sturma Dieter 
Published: July 2013

Abstract
Naturethische Analysen zum ethischen Schutz von Biodiversität müssen mit einer epistemisch und normativ schwierigen Begründungssituation zurechtkommen. Der Ausdruck ‚Biodiversität‘ ist semantisch unscharf und normative Bestimmungen, die sich mit ihm verbinden, vollziehen sich grundsätzlich unter Bedingungen epistemischer Unsicherheit. Der Beitrag entwickelt aus der Perspektive eines integrativen Naturalismus, der gleichermaßen den Ort der humanen Lebensform in der Natur wie die damit einhergehende epistemische und normative Rolle berücksichtigt, eine naturethische Konzeption zum Schutz von Biodiversität. Die Konzeption stützt sich systematisch auf die Kritik exploitativen Verhaltens und asymmetrische Anerkennungsverhältnisse. Die daraus abgeleiteten praktischen Vorschläge stellen einen Zusammenhang zwischen Motivation, begründetem Selbstinteresse und Schutz von Biodiversität her.
Biodiversität als Naturgegenstand?
Authors: Gutmann Mathias 
Published: July 2013

Abstract
Wird Biodiversität als Naturgegenstand angesprochen, bleiben häufig die verschiedenen und durchaus nicht reduzierbaren Konnotationen von ‚Natur‘ unberücksichtigt. Dies führt zur Annahme, Biodiversität sei gleichsam von Hause aus in den Lebenswissenschaften angesiedelt. Das Ziel des Aufsatzes ist es nun umgekehrt, den Sitz solcher Bestimmungen ‚im Leben‘ ausweisend, die Besonderheit der Gegenstandsbestimmung in den Lebenswissenschaften in den Blick zu nehmen und die systematischen Folgen einer solchen Verortung für die lebenswissenschaftliche Theoriebildung selber zu untersuchen. Der zugrunde liegende Funktionalismus weist auf einige fundamentale (Selbst-)Missverständnisse der Lebenswissenschaften hin und zeigt zugleich systematische Alternativen auf.
Biodiversität und die Frage der Ersetzbarkeit
Authors: Birnbacher Dieter 
Published: July 2013

Abstract
Aus mehr als einem Grund ist Biodiversität für die Umweltethik ein hard case. Es ist schwierig, Biodiversität zu definieren und darauf aufbauend zu begründen, warum Biodiversität ein Wert ist und warum es uns ein Anliegen sein sollte, sie zu schützen und zu erhalten. Ein weiteres Problem, das mit Biodiversität als Wertbegriff einhergeht, ist das sogenannte „Substitutionsproblem“. Es besteht darin, dass im Prinzip jede natürliche Entität durch eine andere ersetzt werden kann, so lange sie dieselben Werteigenschaften aufweist. Wie und zu welchem theoretischen Preis lassen sich nun Intuitionen verteidigen, die der ökologischen Ersetzbarkeit widersprechen? Ist Substitution grundsätzlich problematisch oder nur unter besonderen Bedingungen? Gibt es Werte, die, prinzipiell oder faktisch, einen Ersatz ausschließen? Und wie überzeugend sind diese Werte im Kontext des Biodiversitätsschutzes? Meine Schlussfolgerung ist, dass keiner der Werte, die Substitution einschränken, unmittelbar zu den wesentlichen Wert- Dimensionen von Biodiversität beiträgt, sodass sogar im Rahmen eines streng verstandenen Biodiversitätsschutzes (zumindest prinzipiell) breiter Spielraum für anthropogene Ersetzungen besteht.
‚Gehirndoping‘ als legitimes Mittel zur Perfektionierung?
Authors: Glockentöger Ilke , Bittner Uta , Fangerau Heiner 
Published: July 2013

Abstract
Im diachronen Vergleich kann über die Epochen hinweg eine Verschiebung der Gewichtung einzelner Aspekte von Optimierung, Selbstverbesserung oder der Idee eines ‚guten Lebens‘ identifiziert werden. Die analytischen Überlegungen zum Neuro- Enhancement machen deutlich, dass aufklärerische Ideale heute noch wirkmächtig bleiben. Vor allem zum Neuro-Enhancement analoge Leitmotive lassen sich - so die These des Beitrags - in den philanthropischen Theorien der Spätaufklärung finden. Und auch die dort angelegten Widersprüche und Ambivalenzen wirken in die heutigen Diskurse um das Neuro-Enhancement. Ziel dieses Beitrags ist es, den Versuch zu unternehmen, die historischen Ideale eines ‚perfekten Menschen‘ zur heutigen Enhancement-Situation anschlussfähig zu machen.
Evaluation of Antioxidant Enzymes Activity and Malondialdehyde Levels in Patients With Chronic Periodontitis and Diabetes Mellitus
Authors: Trivedi Shilpa , Lal Nand , Mahdi Abbas Ali , Mittal Madhukar , Singh Babita , Pandey Shivani 
Published: July 2013

Background: The aim of this study is to investigate the impact of diabetes, a known risk factor for periodontitis, on activities of antioxidant enzymes superoxide dismutase (SOD), glutathione reductase (GR), and catalase (CAT) as well as levels of free radical damage marker malondialdehyde (MDA) in blood and saliva of individuals with chronic periodontitis (CP).Methods: Sixty patients with CP (30 patients with type 2 diabetes mellitus [DMCP] and 30 systemically healthy patients [CP]) and 60 periodontally healthy individuals (30 patients with type 2 diabetes mellitus and 30 systemically healthy patients [PH]) were included in this study. After clinical measurements, blood and saliva samples were collected. SOD, GR, and CAT activities in red blood cell lysate and saliva and MDA levels in plasma and saliva samples were spectrophotometrically assayed. An analysis of variance test followed by a post hoc test was used to compare the intragroup and intergroup variances among the study groups.Results: MDA levels in both the periodontitis groups were higher than in the periodontally healthy groups, but the difference between the CP and DMCP groups did not reach statistical significance (P >0.05). There was a highly significant difference between the CP and PH groups for all the enzymes studied except for SOD in blood. Only salivary SOD and GR activities were significantly different in the CP and DMCP groups.Conclusions: This study favors the role of oxidative stress in both diabetes and periodontitis. It shows that the compensatory mechanism of the body is partially collapsed because of excessive production of free radicals during periodontitis and is not able to cope with increased free radical generation attributable to diabetes, thereby worsening the situation.
Association Between Edentulism and Angina Pectoris in Mexican Adults Aged 35 Years and Older: A Multivariate Analysis of a Population‐Based Survey
Authors: Medina‐Solís Carlo Eduardo , Pontigo‐Loyola América Patricia , Pérez‐Campos Eduardo , Hernández‐Cruz Pedro , Ávila‐Burgos Leticia , Kowolik Michael J. , Maupomé Gerardo 
Published: July 2013

Background:The possible association between oral infection and chronic inflammation and cardiovascular disease risk has been studied intensively. The present study is designed to determine the strength of association between edentulism and angina pectoris in Mexican adults aged 35 years and older.Methods:Using the tools and sampling strategies of the World Health Survey of the World Health Organization, cross‐sectional data were collected in Mexico in the National Performance Assessment Survey (probabilistic, multistage, and cluster sampling). Dental information was available for 20 of the 32 states of Mexico. Angina and edentulism are self‐reported in this study. Statistical analysis was performed using binary logistic regression adjusting for complex samples.Results:A total of 13,966 participants, representing a population of 29,853,607 individuals, were included. Of the complete study population, 3,052,263 (10.2%) were completely toothless, and 673,810 (2.3%) were diagnosed with angina pectoris. After adjusting for smoking, alcohol consumption, diabetes, body mass index, and sex, the effect of edentulism on angina was modified by age (interaction), being more marked in the younger age group (odds ratio [OR] = exp2.5597=12.93) than in the older individuals surveyed (OR = exp2.5597 + (−0.0334)=12.51). Additionally, low physical activity (OR = 1.51; 95% confidence interval [CI] = 1.03 to 2.22) and higher socioeconomic status (OR = 1.37; 95% CI = 1.00 to 1.90) were more likely to be associated with angina pectoris.Conclusions:Overall, the results of this study, conducted in a representative sample of Mexican adults, suggest that an association exists between edentulism and angina pectoris. Additional studies are necessary to elucidate the underlying mechanism for this association.
Acceleromyography at the Flexor Hallucis Brevis Muscle Underestimates
Residual Neuromuscular Blockade
Authors: Sugi Yasuyuki , Nitahara Keiichi , Katori Kiyoshi , Kusumoto Go , Shigematsu Kenji , Higa Kazuo 
Published: July 2013

Purpose:
Recovery of the train-of-four ratio (TOFR) to > 0.9 in the upper limb is commonly used to determine
that neuromuscular function has returned to the preoperative level. It is not known whether recovery of neuromuscular
function can be determined in the same way using lower limb acceleromyography. We compared measurements of recovery
from neuromuscular blockade using upper limb electromyography and lower limb acceleromyography.

Methods:
Twenty-nine patients who were scheduled for elective surgery were enrolled in this study. Patients were excluded
if they had neuromuscular disease or contraindications to neuromuscular blockade. General anesthesia was induced
and maintained with propofol and fentanyl. Patients were monitored using electromyography at the first dorsal interosseous
muscle of the upper limb and acceleromyography at the flexor hallucis brevis muscle of the lower limb. Vecuronium
0.1 mg/kg was administered for neuromuscular blockade, and the profile of the blockade was recorded, including onset
time and recovery times to TOFR 0.7 and 0.9. Results were compared between the upper and lower limbs.

Results:
The first dorsal interosseous muscle of the upper limb was slower to recover to TOFR 0.7 and 0.9 than the flexor
hallucis brevis muscle. When the TOFR at the flexor hallucis brevis muscle had recovered to 0.9, the TOFR at the first
dorsal interosseous muscle was 0.44 ± 0.23.

Conclusion:
Monitoring the flexor hallucis brevis muscle using acceleromyography underestimates the residual neuromuscular
blockade.
The Role of Dissemination in Market Liquidity: Evidence from Firms' Use of Twitter™
Authors: Blankespoor Elizabeth , Miller Gregory S. , White Hal D. 
Published: July 2013

ABSTRACT
Firm disclosures often reach only a portion of investors, which results in information asymmetry among investors and, therefore, lower market liquidity. This issue is particularly salient for firms that are not highly visible, as they tend not to receive broad news dissemination via traditional intermediaries, such as the press. This paper examines whether firms can reduce information asymmetry by more broadly disseminating their news. To isolate the impact of dissemination, we focus our analysis on firms' use of Twitter and exploit the 140-character message restriction. Specifically, using a sample of technology firms, we examine the impact of using Twitter to send market participants links to press releases that are provided via traditional disclosure methods. We find this additional dissemination of firm-initiated news via Twitter is associated with lower abnormal bid-ask spreads and greater abnormal depths, consistent with a reduction in information asymmetry. Moreover, this result holds mainly for firms that are not highly visible, consistent with them being in greater need of this additional dissemination channel. We also examine the impact of dissemination on a volume-based measure of liquidity, and find that dissemination is positively associated with liquidity.
Data Availability: All data are publicly available from the sources indicated in the paper.