bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic endonasal anatomical study of the cavernous sinus segment of the ophthalmic nerve
Authors: Dolci Ricardo L. L. , Carrau Ricardo L. , Buohliqah Lamia , Zoli Matteo , Mesquita Filho Paulo M. , Lazarini Paulo R. , Ditzel Filho Leo F. S. , Prevedello Daniel M. 
Published: November 2014

Objectives/HypothesisThis cadaveric study analyzes the endoscopic endonasal anatomy of the ophthalmic division of the trigeminal nerve (V1), from the middle fossa to its orbital entry via the superior orbital fissure. Anatomical relationships with the surrounding cranial nerves and blood vessels are described, with emphasis on their clinical correlation during surgery in this region. Our objective was to describe the anatomical relationships of the ophthalmic division of the trigeminal nerve.Study DesignCadaveric study.MethodsThirty middle cranial fossae, in adult human cadaveric specimens, were dissected endonasally under direct endoscopic visualization. During the dissection, we noted the relationships of the V1 nerve with the other trigeminal branches, as well as with the oculomotor and trochlear nerves, the paraclival and cavernous portions of the internal carotid artery, and the superior orbital fissure (SOF).ResultsThe V1 nerve is the most superior trigeminal branch and runs upward and obliquely, along the middle portion of the lateral wall of the cavernous sinus. The V1 nerve joins the oculomotor and trochlear nerves to exit the cavernous sinus and enter the orbit through the SOF. Ten percent of the specimens displayed the trochlear nerve running along as a mate of the V1 nerve. The V1 nerve borders two key triangles in the lateral wall of the cavernous sinus, and the Parkinson's and anteromedial triangles.ConclusionsIn this study, the V1 nerve was a constant and reliable landmark, thus allowing the identification of the anteromedial triangle. This potential space can serve as an adequate window to access the temporal lobe. Knowledge of this anatomy is essential when planning and executing endonasal surgery in this region.Level of EvidenceNA Laryngoscope, 125:1284–1290, 2015
Stable linear traction‐based equilibrium elements for elastostatics: Direct access to linear statically admissible stresses and quadratic kinematically admissible displacements for dual analysis
Authors: Wang Li , Zhong Hongzhi 
Published: November 2014

SummaryThis paper establishes the basic framework for the traction‐based equilibrium finite element method (traction‐based EFEM). Stable linear traction‐based equilibrium elements are formulated using the macro‐element technique. An arbitrary internal macro‐point renders a linear triangular element stable, while a stable linear quadrilateral element requires the macro‐point to locate at the intersection of diagonals. Then, a Lagrangian formulation is utilized to minimize the complementary energy under equilibrium constraints, and consequently, tractions as well as additional Lagrange multipliers are obtained. Linear statically admissible (SA) stresses are thereafter acquired from tractions. As for Lagrange multipliers, they turn out to coincide well with rigid‐body displacements in each element after simple modifications. With rigid‐body displacements and linear tractions known, quadratic displacements and the kinematically admissible (KA) counterpart thereof by recovery are obtainable. The knowledge of both SA stresses and KA displacements renders dual analysis directly applicable. That is to say, the traction‐based EFEM is featured with direct access to strict upper and lower bounds of strain energy and other quantities of interest. Copyright © 2014 John Wiley & Sons, Ltd.
Spontaneous bone metastases in a preclinical orthotopic model of invasive lobular carcinoma; the effect of pharmacological targeting TGFβ receptor I kinase
Authors: Buijs Jeroen T , Matula Kasia M , Cheung Henry , Kruithof‐de Julio Marianna , van der Mark Maaike H , Snoeks Thomas J , Cohen Ron , Corver Willem E , Mohammad Khalid S , Jonkers Jos , Guise Theresa A , van der Pluijm Gabri 
Published: November 2014

AbstractInvasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the most frequently occurring histological subtypes of breast cancer, accounting for 80–90% and 10–15% of the total cases, respectively. At the time of diagnosis and surgical resection of the primary tumour, most patients do not have clinical signs of metastases, but bone micrometastases may already be present. Our aim was to develop a novel preclinical ILC model of spontaneous bone micrometastasis. We used murine invasive lobular breast carcinoma cells (KEP) that were generated by targeted deletion of E‐cadherin and p53 in a conditional K14cre;Cdh1(F/F);Trp53(F/F) mouse model of de novo mammary tumour formation. After surgical resection of the growing orthotopically implanted KEP cells, distant metastases were formed. In contrast to other orthotopic breast cancer models, KEP cells readily formed skeletal metastases with minimal lung involvement. Continuous treatment with SD‐208 (60 mg/kg per day), an orally available TGFβ receptor I kinase inhibitor, increased the tumour growth at the primary site and increased the number of distant metastases. Furthermore, when SD‐208 treatment was started after surgical resection of the orthotopic tumour, increased bone colonisation was also observed (versus vehicle). Both our in vitro and in vivo data show that SD‐208 treatment reduced TGFβ signalling, inhibited apoptosis, and increased proliferation. In conclusion, we have demonstrated that orthotopic implantation of murine ILC cells represent a new breast cancer model of minimal residual disease in vivo, which comprises key steps of the metastatic cascade. The cancer cells are sensitive to the anti‐tumour effects of TGFβ. Our in vivo model is ideally suited for functional studies and evaluation of new pharmacological intervention strategies that may target one or more steps along the metastatic cascade of events. © 2014 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
XPS and resistive studies on thin films of a copper(II)‐based coordination polymer deposited on functionalized interdigital electrodes
Authors: Günthel Michael , Hübscher Jörg , Dittrich Rosemarie , Weber Edwin , Joseph Yvonne , Mertens Florian 
Published: November 2014

ABSTRACTA symmetrical 2‐thiopyrimidine based molecule with an expanded π‐electron system is synthesized and used to form a self‐assembled monolayer (SAM) on gold surfaces. Utilizing chemical vapor deposition a monolayer of (3‐mercaptopropyl)triethoxysilane is formed on silicon dioxide substrates. Both of these SAM coated substrates are characterized by X‐ray photoelectron spectroscopy and the growth of a coordination polymer built up from 5,5′‐(ethyne‐1,2‐diyl)bis(2‐hydroxyacetophenone) and copper(II) on dual SAM coated transducers is studied. After the deposition procedure on interdigital electrodes the electrical properties of the polymer are investigated performing resistive measurements. A significant change of the resistance, which depends on the surrounding atmosphere, proves the sensing behavior of the synthesized coordination polymer. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 53, 335–344
Dynamics of cyclodimerization and viscoelasticity of photo‐crosslinkable PVA
Authors: Bai Huiyu , Xu Jing , Zhang Yanxia , Liu Xiaoya , Rojas Orlando J. 
Published: November 2014

ABSTRACTWe investigated the interfacial properties of poly(vinyl alcohol) carrying UV‐crosslinkable pendant quaternized stilbazole (styrylpyridinium), PVA‐SbQ. The extent and dynamics of PVA‐SbQ cyclodimerization reactions and crosslinking induced by UV irradiation were monitored in situ and in real time by quartz crystal microgravimetry (QCM). Sensograms reflecting time‐dependent changes in density and viscoelasticity of crosslinking films followed a Boltzmann sigmoidal model, depending on precursor film composition and irradiation power. The shifts in QCM frequency and energy dissipation upon PVA‐SbQ cyclodimerization correlated with three photo‐crosslinking phases involving soft‐to‐rigid transitions, namely, induction (initiation), main crosslinking (interaction), and termination. PVA‐SbQ films crosslinked to different degree were used as protein carriers and a slower release profile was determined for the films that underwent more extensive crosslinking. Overall, this study demonstrates for the first time the dynamics of PVA‐SbQ crosslinking and its impact in system viscoelasticity and protein release. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 53, 345–355
Divergent evolution of a bifunctional de novo protein
Authors: Smith Betsy A. , Mularz Ann E. , Hecht Michael H. 
Published: November 2014

AbstractPrimordial proteins, the evolutionary ancestors of modern sequences, are presumed to have been minimally active and nonspecific. Following eons of selective pressure, these early progenitors evolved into highly active and specific proteins. While evolutionary trajectories from poorly active and multifunctional generalists toward highly active specialists likely occurred many times in evolutionary history, such pathways are difficult to reconstruct in natural systems, where primordial sequences are lost to time. To test the hypothesis that selection for enhanced activity leads to a loss of promiscuity, we evolved a de novo designed bifunctional protein. The parental protein, denoted Syn‐IF, was chosen from a library of binary patterned 4‐helix bundles. Syn‐IF was shown previously to rescue two different auxotrophic strains of E. coli: ΔilvA and Δfes. These two strains contain deletions for proteins with very different biochemical functions; IlvA is involved in isoleucine biosynthesis, while Fes is involved in iron assimilation. In two separate experiments, Syn‐IF, was evolved for faster rescue of either ΔilvA or Δfes. Following multiple rounds of mutagenesis, two new proteins were selected, each capable of rescuing the selected function significantly faster than the parental protein. In each case, the evolved protein also lost the ability to rescue the unselected function. In both evolutionary trajectories, the original bifunctional generalist was evolved into a monofunctional specialist with enhanced activity.
Density dependence of the terahertz absorption spectra in optically excited semiconductors
Authors: Thi Hai Le Yen , Inagaki Takeshi J. 
Published: November 2014

AbstractWe theoretically investigate the terahertz (THz) absorption spectra in optically excited direct bandgap bulk semiconductors for various electron–hole (e–h) pair densities with analyzing Coulomb interacting two‐band e–h systems. The exciton Mott transition (the density ionization) can clearly be studied because, above the critical density, the exciton structures originating from the intraexciton transitions disappear and only the Drude component is obtained. The present theory also predicts that the transition energy from 1s to 2p states is almost independent of density below the exciton Mott density. We also study the interplay between the density ionization of excitons and the abrupt increase in the ionization ratio and in the e–h quasi‐chemical potential owing to the quantum dissociation.
Time Point-Based Integrative Analyses of Deep-Transcriptome Identify Four Signal Pathways in Blastemal Regeneration of Zebrafish Lower Jaw
Authors: Zhang Hui , Wang Xuelong , Lyu Kailun , Gao Siqi , Wang Guan , Fan Chunxin , Zhang Xin A. , Yan Jizhou 
Published: November 2014

Abstract
There has been growing interest in applying tissue engineering to stem cell-based regeneration therapies. We have previously reported that zebrafish can faithfully regenerate complicated tissue structures through blastemal cell type conversions and tissue reorganization. To unveil the regenerative factors and engineering arts of blastemal regeneration, we conducted transcriptomal analyses at four time points corresponding to preamputation, re-epitheliation, blastemal formation, and respecification. By combining the hierarchical gene ontology term network, the DAVID annotation system, and Euclidean distance clustering, we identified four signaling pathways: foxi1-foxo1b-pou3f1, pax3a-mant3a-col11/col2, pou5f1-cdx4-kdrl, and isl1-wnt11 PCP-sox9a. Results from immunohistochemical staining and promoter-driven transgenic fish suggest that these pathways, respectively, define wound epidermis reconstitution, cell type conversions, blastemal angiogenesis/vasculogenesis, and cartilage matrix-orientation. Foxi1 morpholino-knockdown caused expansions of Foxo1b- and Pax3a-expression in the basal layer-blastemal junction region. Moreover, foxi1 morphants displayed increased sox9a and hoxa2b transcripts in the embryonic pharyngeal arches. Thus, a Foxi1 signal switch is required to establish correct tissue patterns, including re-epitheliation and blastema formation. This study provides novel insight into a blastema regeneration strategy devised by epithelial cell transdifferentiation, blood vessel engineering, and cartilage matrix deposition. Stem Cells 2015;33:806–818
Improved PMSM model considering flux characteristics for model predictive‐based current control
Authors: Imura Akihiro , Takahashi Tomoya , Fujitsuna Masami , Zanma Tadanao , Doki Shinji 
Published: November 2014

Model predictive‐based current control, which was proposed in our previous study, offers better current response performance by employing mathematical models of an inverter and a permanent magnet synchronous motor (PMSM). The performance of this kind of approach depends on the predictive model. From a more practical point of view, current behavior in the steady state should be improved. In our previous model predictive‐based current control, the inverter model was refined by taking the dead‐time into consideration. The use of the refined inverter model reduces the current offset in the control. However, the PMSM model was not investigated.This paper proposes a more appropriate PMSM model for model predictive‐based current control in order to improve the current prediction in the steady state. For the purpose, we incorporate more detailed magnetic flux characteristics instead of average characteristics into the improved PMSM model. Specifically, in the improved PMSM model, the inductance of the PMSM is divided into transient and steady‐state parts on the basis of magnetic saturation. The effectiveness of the improved model in the model predictive‐based current control is demonstrated through simulations and experiments. © 2014 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Nanomaterials, Inflammation, and Tissue Engineering
Authors: Padmanabhan Jagannath , Kyriakides Themis R. 
Published: November 2014

Nanomaterials exhibit unique properties that are absent in the bulk material because decreasing material size leads to an exponential increase in surface area, surface area to volume ratio, and effective stiffness, resulting in altered physiochemical properties. Diverse categories of nanomaterials such as nanoparticles, nanoporous scaffolds, nanopatterned surfaces, nanofibers, and carbon nanotubes can be generated using advanced fabrication and processing techniques. These materials are being increasingly incorporated in tissue engineering scaffolds to facilitate the development of biomimetic substitutes to replace damaged tissues and organs. Long‐term success of nanomaterials in tissue engineering is contingent upon the inflammatory responses they elicit in vivo. This review seeks to summarize the recent developments in our understanding of biochemical and biophysical attributes of nanomaterials and the inflammatory responses they elicit, with a focus on strategies for nanomaterial design in tissue engineering applications. WIREs Nanomed Nanobiotechnol 2015, 7:355–370. doi: 10.1002/wnan.1320This article is categorized under:

Therapeutic Approaches and Drug Discovery > Emerging Technologies
Implantable Materials and Surgical Technologies > Nanomaterials and Implants
Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement
Was Priscillian a Modalist Monarchian?
Authors: Toom Tarmo 
Published: November 2014

As the first Christian bishop executed by his Christian episcopal opponents through a secular court, Priscillian of Avila has stirred the interest and imagination of many scholars. A well-known problem with reconstructing both Priscillian's life and theology is that, apart from some authentic treatises, most of the information about him comes from the polemical statements of his sworn enemies, such as Ithacius of Ossonuba. Sulpicius Severus contended that Ithacius was a “worthless . . . bold, loquacious, impudent, and extravagant man,” and yet he “poured forth entreaties full of ill-will and accusations against Priscillian.” Although Ithacius's book is lost, writers such as Filaster, Sulpicius Severus, Orosius, Jerome, Consentius, Augustine, Leo the Great, Vincent of Lérins, Prosper of Aquitaine, Hydatius, and Isidore of Seville received their information about Priscillian mostly from Ithacius's book or from the readers of his book. Later perceptions of Priscillian (and Priscillianists) have, no doubt, been influenced by what these prominent figures reiterated following Ithacius.
The defeat of heartbreak: problems and solutions for Stump's view of the problem of evil concerning desires of the heart
Authors: CLEVELAND LINDSAY K. , CLEVELAND W. SCOTT 
Published: November 2014

AbstractEleonore Stump insightfully develops Aquinas's theodicy to account for a significant source of human suffering, namely the undermining of desires of the heart. Stump argues that what justifies God in allowing such suffering is benefits made available to the sufferer through her suffering that can defeat the suffering by contributing to the fulfilment of her heart's desires. We summarize Stump's arguments for why such suffering requires defeat and how it is defeated. We identify three problems with Stump's account of how such suffering is defeated and offer solutions to each. We defend and strengthen Stump's response to the hardest cases for her view, and explain what her view demands of God.
The pharmaceuticalisation of security: Molecular biomedicine, antiviral stockpiles, and global health security
Authors: ELBE STEFAN 
Published: November 2014

AbstractPharmaceuticals are now critical to the security of populations. Antivirals, antibiotics, next-generation vaccines, and antitoxins are just some of the new ‘medical countermeasures’ that governments are stockpiling in order to defend their populations against the threat of pandemics and bioterrorism. How has security policy come to be so deeply imbricated with pharmaceutical logics and solutions? This article captures, maps, and analyses the ‘pharmaceuticalisation’ of security. Through an in-depth analysis of the prominent antiviral medicationTamiflu, it shows that this pharmaceutical turn in security policy is intimately bound up with the rise of a molecular vision of life promulgated by the biomedical sciences. Caught in the crosshairs of powerful commercial, political, and regulatory pressures, governments are embracing a molecular biomedicine promising to secure populations pharmaceutically in the twenty-first century. If that is true, then the established disciplinary view of health as a predominantly secondary matter of ‘low’ international politics is mistaken. On the contrary, the social forces of health and biomedicine are powerful enough to influence the core practices of international politics – even those of security. For a discipline long accustomed to studying macrolevel processes and systemic structures, it is in the end also our knowledge of the minute morass of molecules that shapes international relations.
Health for health's sake, winning for God's sake: US Global Health Diplomacy and smart power in Iraq and Afghanistan
Authors: McINNES COLIN , RUSHTON SIMON 
Published: November 2014

AbstractIdeas of smart power and Global Health Diplomacy have developed considerable prominence over the past decade in, respectively, the foreign policy and public health communities. Although in some respects separate, both suggest the potential for using health assistance to generate political as well as health benefits. The conflicts in Iraq and Afghanistan provide an opportunity to examine these assertions at the ‘sharp end’. We consider both the health and wider strategic benefits of health assistance in these conflicts, as well as some of the ethical challenges involved. We conclude however that we should adopt the precautionary principle because: there is doubt over the quality of health services provided in such circumstances; concern over the wider effects of politicising health aid; and little proof that the claimed strategic benefits materialise in practice.
The rise of companies from emerging markets in global health governance: Opportunities and challenges
Authors: ROEMER-MAHLER ANNE 
Published: November 2014

AbstractThe article analyses the involvement of pharmaceutical companies from emerging markets in global health governance. It finds that they play a central role as low-cost suppliers of medicines and vaccines and, increasingly, new technologies. In so doing, pharmaceutical companies from emerging markets have facilitated the implementation of a key goal of global health policy: widening access to pharmaceutical treatment and prevention. Yet, looking closer at the political economy underlying their involvement, the article exposes a tension between this policy goal and the political economy of pharmaceutical development and production. By declaring access to pharmaceuticals a goal of global health policy, governments and global health partnerships have made themselves dependent on pharmaceutical companies to supply them. Moreover, to provide pharmaceutical treatment and prevention at the global level, they depend on companies to supply medicines and vaccines at extremely low prices. Yet, the development and production of pharmaceuticals is organised around commercial incentives that are at odds with the prices required. The increasing involvement of low-cost suppliers from emerging markets mitigates this tension in the short run. In the long run, this tension endangers the sustainability of global access policies and may even undermine some of the successes already achieved.
A comparison of interview methods to ascertain fluoroquinolone exposure before tuberculosis diagnosis
Authors: VAN DER HEIJDEN Y. F. , MARURI F. , HOLT E. , MITCHEL E. , WARKENTIN J. , STERLING T. R. 
Published: November 2014

SUMMARYFluoroquinolone use before tuberculosis (TB) diagnosis delays the time to diagnosis and treatment, and increases the risk of fluoroquinolone-resistant TB and death. Ascertainment of fluoroquinolone exposure could identify such high-risk patients. We compared four methods of ascertaining fluoroquinolone exposure in the 6 months prior to TB diagnosis in culture-confirmed TB patients in Tennessee from January 2007 to December 2009. The four methods included a simple questionnaire administered to all TB suspects by health department personnel (FQ-Form), an in-home interview conducted by research staff, outpatient and inpatient medical record review, and TennCare pharmacy database review. Of 177 TB patients included, 72 (41%) received fluoroquinolones during the 6 months before TB diagnosis. Fluoroquinolone exposure determined by review of inpatient and outpatient medical records was considered the gold standard for comparison. The FQ-Form had 61% [95% confidence interval (CI) 48–73] sensitivity and 93% (95% CI 85–98) specificity (agreement 79%, kappa = 0·56) while the in-home interview had 28% (95% CI 18–40) sensitivity and 99% (94–100%) specificity (agreement 68%, kappa = 0·29). A simple questionnaire administered by health department personnel identified fluoroquinolone exposure before TB diagnosis with moderate reliability.