bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of resistant starches types II and IV with minimal amounts of oat bran yields good quality, low glycaemic index pasta
Authors: Bustos Mariela Cecilia , Perez Gabriela T. , León Alberto Edel 
Published: September 2012

SummaryThe objective of this work was to study the effects of the combination of resistant starch type II (RSII), resistant starch type IV (RSIV) and oat bran (OB) on technological and nutritional properties of pasta, applying response surface analysis. Cooking properties were improved by combining RSII and RSIV in pasta formulation, while OB addition negatively affected all technological attributes, and a negative synergistic effect was observed between this fibre and resistant starches in cooking losses. Considering nutritional properties, substitution of bread wheat flour with resistant starch type II and IV increased starch resistant to digestion and OB addition increased pasta starch hydrolysis. A positive synergistic effect was observed on glycaemic index by combining both types of resistant starches. Finally, we optimised the formulation considering three aspects separately: technological properties, nutritional attributes and these two features together. The combination of RSII 12.6, RSIV 3.1 and OB 0.6 g per 100 g of wheat flour will allow to obtain a pasta with low glycaemic index (GI = 69) and good technological characteristics.
Investigation of TiO2 nanoparticle efficiency on decolourisation of industrial date syrup
Authors: Nasabi Mahshad , Labbafi Mohsen , HadiNezhad Mehri , Khanmohammadi Mohammadreza , Bagheri Garmarudi Amir 
Published: September 2012

SummaryThe TiO2 nanoparticle photocatalyst was used to decolourise industrial date syrup. The effect of TiO2 concentration (1 and 4% w/v), UV power (15 and 30 w) and processing time (12 and 48 h) on date syrup characteristics was investigated using a factorial design. The colour, turbidity, sugar content, total phenolic compounds, ash content and mineral (K, Na, Ca, Mg and Fe) of date syrup were analysed. The results demonstrated that using TiO2 nanoparticle as a photocatalyst for the decolourisation of date syrup is an effective and promising method. Colour in all treatments was significantly (P < 0.05) reduced between 30 and 53% in comparison with the initial date syrup (491 000 IU), and the reduction was even higher for date syrup turbidity (between 47 and 75%). The result showed that the process condition significantly affected the colour and turbidity reduction. On the basis of the result, the best treatment was TiO2 4%, 15 w and 48 h. Under this condition, date syrup colour, turbidity, ash content, sugar content reduced by 52%, 61%, 13% and 9%, respectively.
New insights into the biogeography of south‐western Europe: spatial patterns from vascular plants using cluster analysis and parsimony
Authors: Moreno Saiz Juan Carlos , Donato Mariano , Katinas Liliana , Crisci Jorge V. , Posadas Paula 
Published: September 2012

AbstractAimWe analysed the distributional pattern of the vascular flora of the Iberian Peninsula and Balearic archipelago using cluster and parsimony methods to delineate a biogeographical scheme for south‐western Europe and to compare the results with previous regionalizations. Additionally, we aim to identify areas of endemism.LocationSouth‐western Europe (Iberian Peninsula and the Balearic Islands).MethodsPattern analysis of a chorological dataset, consisting of the occurrences of 3041 vascular plant species in each of the 50 km × 50 km UTM cells of a grid covering Iberia and the Balearic Islands, was based on cluster analysis (unweighted pair‐group method using arithmetic averages; UPGMA) and parsimony analysis of endemicity (PAE). The Jaccard similarity index was used in the UPGMA, and the set of most parsimonious trees from the PAE were summarized in a 75% majority consensus tree.ResultsThe UPGMA dendrogram delineated two main branches in the study region: (1) an eastern area of six sectors including the Balearic Islands plus those regions of Iberia with basic substrates, and (2) a western area with three sectors comprising the regions with acidic soils. The majority rule consensus tree of 53 most parsimonious trees from PAE showed eight main clades similarly separating eastern Iberia plus the Balearic Islands with their basic substrates, from western Iberia with its acidic and basic substrates; in addition the PAE tree showed some previously undetected chorological patterns.Main conclusionsThe use of large and inclusive datasets allows for the recognition of different spatial patterns from those obtained using a limited number of endemic or indicator species. The analyses support some floristic regions previously recognized for Iberia, but not the classic Eurosiberian–Mediterranean division, and some transition territories. Our recognition of 19 areas of endemism consisting of two or more cells and 60 consisting of one cell in south‐western Europe is new.
Snails on oceanic islands: testing the general dynamic model of oceanic island biogeography using linear mixed effect models
Authors: Cameron Robert A. D. , Triantis Kostas A. , Parent Christine E. , Guilhaumon François , Alonso María R. , Ibáñez Miguel , de Frias Martins António M. , Ladle Richard J. , Whittaker Robert J. 
Published: September 2012

AbstractAimWe collate and analyse data for land snail diversity and endemism, as a means of testing the explanatory power of the general dynamic model of oceanic island biogeography (GDM): a theoretical model linking trends in species immigration, speciation and extinction to a generalized island ontogeny.LocationEight oceanic archipelagos: Azores, Canaries, Hawaii, Galápagos, Madeira, Samoa, Society, Tristan da Cunha.MethodsUsing data obtained from literature sources we examined the power of the GDM through its derivative ATT2 model (i.e. diversity metric = b1 + b2Area + b3Time + b4Time2), in comparison with all the possible simpler models, e.g. including only area or time. The diversity metrics considered were the number of (1) native species, (2) archipelagic endemic species, and (3) single‐island endemic species. Models were evaluated using both log‐transformed and untransformed diversity data by means of linear mixed effect models. For Hawaii and the Canaries, responses of different major taxonomic groups were also analysed separately.ResultsThe ATT2 model was always included within the group of best models and, in many cases, was the single‐best model and was particularly successful in fitting the log‐transformed diversity metrics. In four archipelagos, a hump‐shaped relationship with time (island age) is apparent, while the other four archipelagos show a general increase of species richness with island age. In Hawaii and the Canaries outcomes vary between different taxonomic groups.Main conclusionsThe GDM is an intentionally simplified representation of environmental and diversity dynamics on oceanic islands, which predicts a simple positive relationship between diversity and island area combined with a humped response to time. We find broad support for the applicability of this model, especially when a full range of island developmental stages is present. However, our results also show that the varied mechanisms of island origins and the differing responses of major taxa should be taken into consideration when interpreting diversity metrics in terms of the GDM. This heterogeneity is reflected in the fact that no single model outperforms all the other models for all datasets analysed.
An integrated model of clinical reasoning: dual‐process theory of cognition and metacognition
Authors: Marcum James A. 
Published: September 2012

AbstractRationale and aimClinical reasoning is an important component for providing quality medical care. The aim of the present paper is to develop a model of clinical reasoning that integrates both the non‐analytic and analytic processes of cognition, along with metacognition.MethodThe dual‐process theory of cognition (system 1 non‐analytic and system 2 analytic processes) and the metacognition theory are used to develop an integrated model of clinical reasoning.ResultsIn the proposed model, clinical reasoning begins with system 1 processes in which the clinician assesses a patient's presenting symptoms, as well as other clinical evidence, to arrive at a differential diagnosis. Additional clinical evidence, if necessary, is acquired and analysed utilizing system 2 processes to assess the differential diagnosis, until a clinical decision is made diagnosing the patient's illness and then how best to proceed therapeutically. Importantly, the outcome of these processes feeds back, in terms of metacognition's monitoring function, either to reinforce or to alter cognitive processes, which, in turn, enhances synergistically the clinician's ability to reason quickly and accurately in future consultations.ConclusionsThe proposed integrated model has distinct advantages over other models proposed in the literature for explicating clinical reasoning. Moreover, it has important implications for addressing the paradoxical relationship between experience and expertise, as well as for designing a curriculum to teach clinical reasoning skills.
Principles of reasoning in historical epidemiology
Authors: Tulodziecki Dana 
Published: September 2012

AbstractThe case ofJohnSnow has long been important to epidemiologists and public health officials. However, despite the fact that there have been many discussions about the various aspects ofSnow's case, there has been virtually no discussion about what guidedSnow's reasoning in his coming to believe his various conclusions about cholera. Here, I want to take up this question in some detail and show that there are a number of specific principles of reasoning that played a crucial role forSnow. Moreover, these principles were epistemologically important toSnow, a fact about whichSnow is explicit in many places. An analysis ofSnow's case suggests that, because of the epistemic role such principles of reasoning can play, health care practitioners ought to understand their practices to be theoretically informed in these ways, and not just data driven.
Challenging the epistemological foundations of EBM: what kind of knowledge does clinical practice require?
Authors: Hutchison Katrina J. , Rogers Wendy A. 
Published: September 2012

AbstractThis paper raises questions about the epistemological foundations of evidence‐based medicine (EBM). We argue that EBM is based upon reliabilist epistemological assumptions, and that this is appropriate – we should focus on identifying the most reliable processes for generating and collecting medical knowledge. However, we note that this should not be reduced to narrow questions about which research methodologies are the best for gathering evidence. Reliable processes for generating medical evidence might lie outside of formal research methods. We also question the notion of the knower that is assumed by EBM. We argue that EBM assumes an enlightenment conception of knowers as autonomous, substitutable individuals. This conception is troubled by the way that clinicians learn the role of anecdote in health care and the role of patient choice, all of which bring into play features of clinicians and patients as situated individuals with particular backgrounds and experiences. EBM's enlightenment conception of the knower is also troubled by aspects of the way evidence is produced. Given these limitations, we argue that EBM should retain its reliabilist bent, but should look beyond formal research methodologies in identifying processes that yield reliable evidence for clinical practice. We suggest looking to feminist epistemology, with its focus on the standpoints of individual situated knowers, and the role of social context in determining what counts as knowledge.
Mechanisms: what are they evidence for in evidence‐based medicine?
Authors: Andersen Holly 
Published: September 2012

AbstractEven though the evidence‐based medicine (EBM) movement labels mechanisms a low quality form of evidence, consideration of the mechanisms on which medicine relies, and the distinct roles that mechanisms might play in clinical practice, offers a number of insights into EBM itself. In this paper, I examine the connections between EBM and mechanisms from several angles. I diagnose what went wrong in two examples where mechanistic reasoning failed to generate accurate predictions for how a dysfunctional mechanism would respond to intervention. I then use these examples to explain why we should expect this kind of mechanistic reasoning to fail in systematic ways, by situating these failures in terms of evolved complexity of the causal system(s) in question. I argue that there is still a different role in which mechanisms continue to figure as evidence in EBM: namely, in guiding the application of population‐level recommendations to individual patients. Thus, even though the evidence‐based movement rejects one role in which mechanistic reasoning serves as evidence, there are other evidentiary roles for mechanistic reasoning. This renders plausible the claims of some critics of EBM who point to the ineliminable role of clinical experience. Clearly specifying the ways in which mechanisms and mechanistic reasoning can be involved in clinical practice frames the discussion about EBM and clinical experience in more fruitful terms.
The application of Cartwright's concept of capacities to complex interventions in psychiatry
Authors: Hubbeling Dieneke 
Published: September 2012

AbstractCartwright and Munro argued that extrapolation of findings from randomized controlled trials to other settings can be difficult because information about the underlying causal structure and subgroups is often not available. They advocated the use of ‘capacities’ – that is fixed causal contributions – in predicting effects of interventions. In psychiatry, it is often not possible to determine what the fixed causal contributions are and one can only establish ‘approximate capacities’. However, using ‘approximate capacities’ does imply a different way of evaluating health services, especially combined interventions. In health service research, if different studies, randomized controlled trials or other designs, have given different outcomes, the best way to investigate the effectiveness of a particular way of service organization is not to conduct more randomized controlled trials. It is preferable to study the effects of certain elements of the complex intervention, which have been tested before in other settings, that is investigating ‘approximate capacities’. One should check whether the separate elements do form a part of the complex intervention in practice and whether they have the same effect as in other studies and if not, why not. This enhances knowledge about the underlying causal structure and increases the possibility of extrapolation of the findings.
Autonomy and reason: treatment choice in breast cancer
Authors: Twomey Mary 
Published: September 2012

AbstractThe practice of offering choice to those women with breast cancer for whom either breast conserving surgery or mastectomy would be equally beneficial has come to be seen as an important aspect of medical care. As well as improving satisfaction with treatment, this is seen as satisfying the ethical principle of respect for autonomy. A number of studies, however, show that women are not always comfortable with such choice, preferring to leave treatment decisions to their surgeons. A question then arises as to the extent that these women can be seen as autonomous or as exercising autonomy. This paper argues, however, that the understanding of autonomy which is applied in current approaches to breast cancer care does not adequately support the exercise of autonomy, and that the clinical context of care means that women are not able to engage in the kind of reasoning that might promote the exercise of autonomy. Where respect for autonomy is limited to informed consent and choice, there is a danger that women's interests are overlooked in those aspects of their care where choice is not appropriate, with very real, long‐term consequences for some women. Promoting the exercise of autonomy, it is argued, needs to go beyond the conception of autonomy as rational individuals making their own decisions, and clinicians need to work with an understanding of autonomy as relational in order to better involve women in their care.
Can there be a good death?
Authors: Scarre Geoffrey 
Published: September 2012

AbstractWhile some deaths are worse than others, there is no such thing as a ‘good death’ since the plausible desiderata of a ‘good death’ form an inconsistent set. Because death is of the greatest existential consequence to us, a ‘good’ death must be a self‐aware death in which we grasp the import of what is happening to us; however, such realization is incompatible with our achieving the tranquillity of mind which is another requirement for the ‘good’ death. Nevertheless, the welcome recognition in recent years by medical personnel, palliative care workers and hospice staff that dying is an existential predicament as well as a physiological condition has enabled more people to avoid a ‘soulless death in intensive care’, even if it pays insufficient regard to the personal virtues that we need if we are to mitigate the worst evils of dying.
Medicine and the individual: is phenomenology the answer?
Authors: Gergel Tania L. 
Published: September 2012

AbstractThe issue of how to incorporate the individual's first‐hand experience of illness into broader medical understanding is a major question in medical theory and practice. In a philosophical context, phenomenology, with its emphasis on the subject's perception of phenomena as the basis for knowledge and its questioning of naturalism, seems an obvious candidate for addressing these issues. This is a review of current phenomenological approaches to medicine, looking at what has motivated this philosophical approach, the main problems it faces and suggesting how it might become a useful philosophical tool within medicine, with its own individual, but interrelated, contribution to make to current medical debates. After the general background, there is a brief summary of phenomenological ideas and their current usage in a medical context. Next is a critique of four key claims within current phenomenological medical works, concerning both the role phenomenology plays and the supposedly clear divide between phenomenology and other approaches. There are significant problems within these claims, largely because they overlook the complexity of the questions they consider. Finally, there is some more in‐depth examination of phenomenology itself and the true complexity of phenomenological debate concerning subjectivity. The aim is to show that it will be both more productive and truer to phenomenology itself, if we use phenomenology as a philosophical method for explicating and gaining deeper understanding of complex and fundamental problems, which are central to medicine, rather than as providing simple, but flawed solutions.
Pleistocene survival on central Alpine nunataks: genetic evidence from the jumping bristletail Machilis pallida
Authors: Wachter Gregor A. , Arthofer Wolfgang , Dejaco Thomas , Rinnhofer Lukas J. , Steiner Florian M. , Schlick‐Steiner Birgit C. 
Published: September 2012

AbstractMechanisms of survival during the Pleistocene glaciation periods have been studied for more than a century. Until now, molecular studies that confirmed animal survival on Alpine nunataks, that is, ice‐free summits surrounded by glaciers, were restricted to peripheral areas. Here, we search for molecular signatures of inner‐Alpine survival of the narrow endemic and putatively parthenogenetic Alpine jumping bristletail Machilis pallida combining mitochondrial and AFLP data from its three known populations. The mitochondrial data indicate survival on both peripheral and central nunataks, the latter suggesting that refugia in the centre of the Alpine main ridge were more widespread than previously recognized. Incongruences between mitochondrial and AFLP patterns suggest a complex evolutionary history of the species and may be explained via parallel fixation of parthenogenesis of different origins during the last glacial maximum. We suggest that the inferred parthenogenesis may have been essential for central nunatak survival, but may pose a serious threat for M. pallida in consideration of the present climatic changes.
Associations of CD6, TNFRSF1A and IRF8 polymorphisms with risk of inflammatory demyelinating diseases
Authors: Park T.‐J. , Kim H. J. , Kim J.‐H. , Bae J. S. , Cheong H. S. , Park B.‐L. , Shin H. D. 
Published: September 2012

AimsMultiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory autoimmune diseases that affect the central nervous system. Several genome‐wide and candidate gene studies have identified genetic polymorphisms associated with the risk of MS or NMO. In particular, two recently published studies of meta‐analysis in European‐origin populations have suggested associations of single‐nucleotide polymorphisms (SNPs) in CD6, TNFRSF1A and IRF8 with MS. The aim of our study was to assess the associations between SNPs in these three genes and the risk of inflammatory demyelinating disease (IDD) including MS and NMO. To the best of our knowledge, this is the first time such a study has been performed in an Asian population.MethodsA total of 21 SNPs of CD6, TNFRSF1A and IRF8 were genotyped in 178 IDD cases (79 MS and 99 NMO patients) and 237 normal controls in a Korean population.ResultsLogistic analyses revealed that one SNP in CD6 (rs12288280, P = 0.04) and three SNPs in TNFRSF1A (rs767455, rs4149577 and rs1800693, P = 0.01–0.03) were associated with NMO. However, there was no association of IRF8 polymorphisms with IDD, including MS and NMO. Using further information from the SNP Function Prediction website, two exonic splicing enhancers (ESEs), including the polymorphic site of rs767455, were predicted to be binding sites for splicing factors (SRp55, SF2/ASF2 and SF2/ASF1).ConclusionAlthough additional studies are needed, our findings could provide information regarding the genetic aetiology of IDD in the Korean population.
Cryoprecipitate: an outmoded treatment?
Authors: Yang L. , Stanworth S. , Baglin T. 
Published: September 2012

SUMMARYCryoprecipitate is an allogeneic blood product prepared from human plasma. It contains factors VIII, von Willebrand factor (vWF), fibrinogen, fibronectin and factor XIII. Its use was first described in the 1960s for treatment of patients with factor VIII deficiency. It has also been used to treat patients with congenital hypofibrinogenaemia. Now, the most common use of cryoprecipitate is fibrinogen replacement in patients with acquired hypofibrinogenaemia and bleeding. Despite almost 50 years of use, evidence of efficacy is limited. This review provides an overview of the history of cryoprecipitate use, the current debates on the use of this product and future developments.
Caring for new mothers: diagnosis, management and treatment of nipple dermatitis in breastfeeding mothers
Authors: Heller Misha M. , Fullerton‐Stone Honor , Murase Jenny E. 
Published: September 2012

AbstractBreastfeeding is thought to be the most optimal form of infant nutrition. Nursing mothers are generally advised to continue breastfeeding until the infant is two years of age or beyond. Unfortunately, however, a majority of nursing mothers will discontinue breastfeeding much earlier than recommended. The most common reason for early discontinuation of breastfeeding is nipple pain. It is, therefore, essential that dermatologists know how to appropriately diagnose and effectively treat nipple pain associated with nipple dermatitis among nursing mothers. This review article provides a detailed discussion on the clinical features and management of various causes of nipple dermatitis during lactation, including problems with infant latch‐on, congenital oral anomalies, plugged lactiferous ducts, atopic dermatitis, irritant contact dermatitis, allergic contact dermatitis, yeast infections, bacterial infections, herpes simplex virus, and Raynaud’s phenomenon of the nipple.