bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le culte, la collecte, l'apostolat : des liturgies de reconnaissance chez l'apôtre Paul
Authors: Combet-Galland Corina 
Published: September 2014

L’écriture évangélique est travail de reconnaissance ; elle tisse la mort du prophète Jésus sur la trame des Écritures bibliques, transfigure ainsi la fin en commencement. Dans les premiers textes où s’élabore la foi en Christ, les lettres de l’apôtre Paul, trois gestes, à dimension liturgique, portent la dynamique structurante de la reconnaissance. La vie croyante elle-même est d’abord comprise comme un culte , une offrande vivante de soi à Dieu ; mais si la foi de chacun n’est qu’une part, reçue en partage, le culte implique la complémentarité des membres, il exige une juste estime de chacun pour chacun. La collecte ensuite, entreprise par Paul dans les cités du bassin méditerranéen en faveur de la communauté de Jérusalem, œuvre au lien et se teinte d’expressions liturgiques : elle se met au service de la communion, est largesse qui se fait louange, eucharistie rendue au Dieu de toute grâce. Enfin l’ apostolat : il n’a pour lisibilité que le don de soi, marqué de l’amour poignant du Crucifié, et pour authentification, la communauté elle-même, ainsi sollicitée, en sa vivacité.
Parcours de la reconnaissance dans l'entreprise
Authors: Renouard Cécile 
Published: September 2014

Comment la sphère économique et en particulier l’institution entreprise peuvent-elles favoriser la reconnaissance de la valeur morale et sociale de chaque personne ? Trois dimensions centrales de la reconnaissance sont appliquées à l’analyse du fonctionnement des entreprises. La première dimension, celle du déploiement de l’identité relationnelle des personnes, peut être visée comme l’horizon et la finalité ultime de l’entreprise (et de toute institution). La deuxième dimension, celle du respect et de l’estime de soi, définit les conditions de la réalisation de ces capacités relationnelles. Il s’agit, d’une part, de définir des frontières, pour éviter que la sphère marchande n’envahisse les autres et, d’autre part, de repenser les critères de grandeur/domination à l’œuvre dans la sphère de l’entreprise et de mettre en évidence les inégalités illégitimes, en fixant des bornes. Il est aussi nécessaire de faire valoir les ressources éthiques et spirituelles à notre disposition, pour lutter contre les pathologies sociales engendrées par le modèle économique libertarien, financiarisé et court-termiste. Ces ressources spirituelles apparaissent bien dans la troisième dimension de la reconnaissance, celle de la gratitude : cette dimension fonde les autres, elle est celle sur laquelle, implicitement, tout contrat s’appuie, mais elle est également appelée à trouver un espace explicite au sein des entreprises.
Les institutions hospitalières : des institutions de la reconnaissance ?
Authors: Pierron Jean-Philippe 
Published: September 2014

Comme leur nom l’indique, les institutions hospitalières tentent d’être la traduction et la transcription sociale d’une éthique de l’hospitalité. À la sollicitude eu égard à l’homme vulnérabilisé par la maladie, le handicap ou le vieillir, vécue dans la relation interpersonnelle, elles tentent d’apporter le prolongement et la réplique d’un ensemble de médiations institutionnelles tout à la fois théoriques (une épistémologie et une sémiologie de la maladie) et pratiques (une sémantique de l’action interprétant la biographie de l’homme malade). Or c’est à cet endroit que les enjeux théoriques et pratiques de la reconnaissance s’inscrivent et se déploient, car l’institution hospitalière vit d’un tiraillement constitutif. Elle place épistémologiquement la reconnaissance sous le régime conceptuel de l’identification (vérité de science). Mais elle vise éthiquement et politiquement une reconnaissance mutuelle de la maladie comme épreuve existentielle (vérité d’existence), sous peine de fabriquer de la non-reconnaissance, qu’elle soit humiliation, irrespect ou mépris. À quelles conditions l’institution hospitalière peut-elle être une institution de la reconnaissance si d’une part elle est dominée par la survalorisation du connaître sur le reconnaître ; et si d’autre part la bureaucratisation croissante du monde hospitalier dévalue les pratiques de coopérations et de reconnaissance au profit du souci gestionnaire de coordination ?
Dette, gratitude et libération
Authors: Müller Denis 
Published: September 2014

L’auteur reconstruit le débat sur la reconnaissance à partir des travaux de Honneth, Ricœur et Hénaff. Après avoir souligné l’actualité sociale de cette thématique, il s’interroge sur sa genèse, puis s’efforce de saisir la dimension de transcendance sans laquelle la reconnaissance risquerait de tourner sur elle-même. Remontant, avec Fischbach, à Hegel et à Fichte, il convient de se demander aussi comment la thématique de la réciprocité ne court-circuite pas celle de la différence. La notion d’injustice est en effet trop souvent tirée du côté d’une stricte égalité, sans tenir compte des situations différenciées des personnes concernées. La discussion sur le partenariat entre personnes de même sexe (PACS), puis, plus radicalement, sur le « mariage pour tous », fournit un bon exemple de la double dimension, sociale et religieuse, de la reconnaissance. Les ambiguïtés du langage de la reconnaissance ne sauraient conduire ni à un simple égalitarisme, ni à un différentialisme qui se détournerait de la visée fondamentale d’équité sans laquelle il n’y aurait plus d’éthique sociale. La dimension proprement religieuse de la reconnaissance vient alors rappeler la nécessaire a-symétrie qui fait de la reconnaissance un événement de décentrement, par-delà toute mise à plat.
La grande pauvreté, pierre de touche pour la question de la reconnaissance
Authors: Grieu Étienne 
Published: September 2014

Le présupposé qui guide l’auteur est que la rencontre des personnes marquées par la grande pauvreté joue comme un révélateur pour penser la reconnaissance. À leur contact en effet, on est conduit à distinguer deux aspects dans le travail de reconnaissance : une lutte dans laquelle les protagonistes font l’épreuve de leur identité en confrontant leurs capacités, d’une part, et, d’autre part, un appel à l’existence, qui n’a pas d’autre « parce que » en dehors d’un « parce que c’est toi ». L’auteur souligne l’importance cruciale de ce deuxième aspect lorsqu’un chemin s’engage avec des personnes en grande précarité. À partir de là, on peut revisiter l’ensemble des rapports sociaux comme une combinaison de rapports de forces et d’appels grâce auxquels nous nous redisons mutuellement que « nous ne sommes pas des choses », selon la formule de Claude Lefort. Cette distinction permet d’interroger en retour les formes instituées du vivre-ensemble en posant la question de la place faite à ce deuxième versant de la reconnaissance ainsi qu’aux moyens de lui donner force et consistance.
Ouverture à propos de la reconnaissance institutionnelle dans la société contemporaine
Authors: Causse Jean-Daniel 
Published: September 2014

En conclusion du dossier, Jean-Daniel Causse reprend la question de la reconnaissance du point de vue des enjeux institutionnels contemporains. Avec une critique du concept de reconnaissance, trois aspects sont développés : d’abord, il faut se demander si une réponse à la demande de reconnaissance doit toujours être adéquate, ou symétrique, ou si elle n’a pas à assumer une part de dissymétrie ou d’écart qui n’en reste pas moins une façon de répondre à la quête de reconnaissance. Ensuite, on peut s’interroger sur la question de savoir si l’acte de reconnaissance ne comporte pas toujours le risque d’enfermer l’autre dans ce dans quoi on le reconnaît. Comment penser alors des modalités sociales et politiques de la reconnaissance qui préservent la capacité pour chacun de ne pas être seulement confondu avec des formes de soi et qui soutiennent une indétermination subjective ? Enfin, on peut faire retour à cette forme de reconnaissance communautaire mise en place dans le christianisme où les différences culturelles, sociales, mais aussi les particularités de chacun, sont reconnues en fonction de ce qui n’est la propriété de personne et dont le Christ du tombeau vide est la figure. La reconnaissance mutuelle se construit grâce à ce qui n’étant à personne est offert à chacun.
Mycobacterium tuberculosisDecreases Human Macrophage IFN-γ Responsiveness through miR-132 and miR-26a
Authors: Ni Bin , Rajaram Murugesan V. S. , Lafuse William P. , Landes Michelle B. , Schlesinger Larry S. 
Published: September 2014

AbstractIFN-γ–activated macrophages play an essential role in controlling intracellular pathogens; however, macrophages also serve as the cellular home for the intracellular pathogen Mycobacterium tuberculosis. Based on previous evidence that M. tuberculosis can modulate host microRNA (miRNA) expression, we examined the miRNA expression profile of M. tuberculosis–infected primary human macrophages. We identified 31 differentially expressed miRNAs in primary human macrophages during M. tuberculosis infection by NanoString and confirmed our findings by quantitative real-time RT-PCR. In addition, we determined a role for two miRNAs upregulated upon M. tuberculosis infection, miR-132 and miR-26a, as negative regulators of transcriptional coactivator p300, a component of the IFN-γ signaling cascade. Knockdown expression of miR-132 and miR-26a increased p300 protein levels and improved transcriptional, translational, and functional responses to IFN-γ in human macrophages. Collectively, these data validate p300 as a target of miR-132 and miR-26a, and demonstrate a mechanism by which M. tuberculosis can limit macrophage responses to IFN-γ by altering host miRNA expression.
Effective Innate and Adaptive Antimelanoma Immunity through Localized TLR7/8 Activation
Authors: Singh Manisha , Khong Hiep , Dai Zhimin , Huang Xue-Fei , Wargo Jennifer A. , Cooper Zachary A. , Vasilakos John P. , Hwu Patrick , Overwijk Willem W. 
Published: September 2014

Abstract
Intratumoral immune activation can induce local and systemic antitumor immunity. Imiquimod is a cream-formulated, TLR7 agonist that is Food and Drug Administration approved for the treatment of nonmelanoma skin cancers, but it has limited activity against melanoma. We studied the antitumor activity and mechanism of action of a novel, injectable, tissue-retained TLR7/8 agonist, 3M-052, which avoids systemic distribution. Intratumoral administration of 3M-052 generated systemic antitumor immunity and suppressed both injected and distant, uninjected wild-type B16.F10 melanomas. Treated tumors showed that an increased level of CCL2 chemokines and infiltration of M1 phenotype–shifted macrophages, which could kill tumor cells directly through production of NO and CCL2, were essential for the antitumor activity of 3M-052. CD8+ T cells, B cells, type I IFN, IFN-γ, and plasmacytoid dendritic cells were contributed to efficient tumor suppression, whereas perforin, NK cells, and CD4 T cells were not required. Finally, 3M-052 therapy potentiated checkpoint blockade therapy with anti–CTLA-4 and anti–programmed death ligand 1 Abs, even when checkpoint blockade alone was ineffective. Our findings suggest that intratumoral treatment with 3M-052 is a promising approach for the treatment of cancer and establish a rational strategy and mechanistic understanding for combination therapy with intratumoral, tissue-retained TLR7/8 agonist and checkpoint blockade in metastatic cancer.
Biomarkers in Lung Adenocarcinoma: A Decade of Progress
Authors: Sholl Lynette M. 
Published: September 2014

ContextThe analysis of molecular biomarkers in lung adenocarcinoma (ACA) is now a central component of pathologic diagnosis and oncologic care. The identification of an EGFR mutation or ALK rearrangement in advanced-stage lung ACA will dictate a change in first-line treatment from standard chemotherapy to targeted inhibition of these oncogenic alterations. Viable approaches to therapeutic targeting of KRAS-mutated ACA are now under investigation, raising the possibility that this too will become an important predictive marker in this tumor type. The recognized array of less common oncogenic alterations in lung ACA, including in the ROS1, RET, BRAF, and ERBB2 genes, is growing rapidly. The therapeutic implications of these findings are, in many cases, still under investigation.ObjectiveTo focus on the major molecular biomarkers in lung ACA, recommended testing strategies, the implications for targeted therapies, and the mechanisms that drive development of resistance.Data SourcesOur current understanding of predictive and prognostic markers in lung ACA is derived from a decade of technical advances, clinical trials, and epidemiologic studies. Many of the newest discoveries have emerged from application of high-throughput next-generation sequencing and gene expression analyses in clinically and pathologically defined cohorts of human lung tumors.ConclusionsBest practices require a solid understanding of relevant biomarkers for diagnosis and treatment of patients with lung ACA.
Detection time for global and regional sea level trends and accelerations
Authors: Jordà G. 
Published: September 2014

AbstractMany studies analyze trends on sea level data with the underlying purpose of finding indications of a long‐term change that could be interpreted as the signature of anthropogenic climate change. The identification of a long‐term trend is a signal‐to‐noise problem where the natural variability (the “noise”) can mask the long‐term trend (the “signal”). The signal‐to‐noise ratio depends on the magnitude of the long‐term trend, on the magnitude of the natural variability, and on the length of the record, as the climate noise is larger when averaged over short time scales and becomes smaller over longer averaging periods. In this paper, we evaluate the time required to detect centennial sea level linear trends and accelerations at global and regional scales. Using model results and tide gauge observations, we find that the averaged detection time for a centennial linear trend is 87.9, 76.0, 59.3, 40.3, and 25.2 years for trends of 0.5, 1.0, 2.0, 5.0, and 10.0 mm/yr, respectively. However, in regions with large decadal variations like the Gulf Stream or the Circumpolar current, these values can increase up to a 50%. The spatial pattern of the detection time for sea level accelerations is almost identical. The main difference is that the length of the records has to be about 40–60 years longer to detect an acceleration than to detect a linear trend leading to an equivalent change after 100 years. Finally, we have used a new sea level reconstruction, which provides a more accurate representation of interannual variability for the last century in order to estimate the detection time for global mean sea level trends and accelerations. Our results suggest that the signature of natural variability in a 30 year global mean sea level record would be less than 1 mm/yr. Therefore, at least 2.2 mm/yr of the recent sea level trend estimated by altimetry cannot be attributed to natural multidecadal variability.
An integrated database of ocean temperature and salinity observations
Authors: Atkinson Christopher P. , Rayner Nick A. , Kennedy John J. , Good Simon A. 
Published: September 2014

AbstractObservations made by surface‐based instruments and subsurface profiling instruments have, up to now, largely been treated separately, motivated by a focus on different aspects of the climate system. However, activities such as coupled climate reanalyses, long‐term forecasting, satellite validation, and climate monitoring increasingly want observations from both sets of instruments. To address this, we create an “Integrated” Ocean Database of global in situ temperature and salinity observations covering 1900–2010, which we name HadIOD. The database merges data taken from the latest versions of the International Comprehensive Ocean‐Atmosphere Data Set (surface observations) and the Met Office Hadley Centre EN dataset (subsurface observations). Duplicates introduced by this process are flagged. In addition to the measurements and their basic metadata, each observation in the database is allocated a unique identifier, quality flags and, where possible, bias corrections and uncertainty estimates. A short investigation is presented demonstrating the use, and value, of some of the bias corrections and uncertainties in the database. While this paper describes our initial attempt at building HadIOD, there is much that could be done to build on the foundations presented here. Some ideas for future development are discussed.
The effect of differences in methodology among some recent applications of shearing quotients
Authors: Boyer Doug M. , Winchester Julia , Kay Richard F. 
Published: September 2014

ABSTRACTA shearing quotient (SQ) is a way of quantitatively representing the Phase I shearing edges on a molar tooth. Ordinary or phylogenetic least squares regression is fit to data on log molar length (independent variable) and log sum of measured shearing crests (dependent variable). The derived linear equation is used to generate an ‘expected’ shearing crest length from molar length of included individuals or taxa. Following conversion of all variables to real space, the expected value is subtracted from the observed value for each individual or taxon. The result is then divided by the expected value and multiplied by 100. SQs have long been the metric of choice for assessing dietary adaptations in fossil primates. Not all studies using SQ have used the same tooth position or crests, nor have all computed regression equations using the same approach. Here we focus on re‐analyzing the data of one recent study to investigate the magnitude of effects of variation in 1) shearing crest inclusion, and 2) details of the regression setup. We assess the significance of these effects by the degree to which they improve or degrade the association between computed SQs and diet categories. Though altering regression parameters for SQ calculation has a visible effect on plots, numerous iterations of statistical analyses vary surprisingly little in the success of the resulting variables for assigning taxa to dietary preference. This is promising for the comparability of patterns (if not casewise values) in SQ between studies. We suggest that differences in apparent dietary fidelity of recent studies are attributable principally to tooth position examined. Am J Phys Anthropol 156:166–178, 2015 © 2014 Wiley Periodicals, Inc.
Quality of life improvement from sinus surgery in chronic rhinosinusitis patients with asthma and nasal polyps
Authors: Zhang Zi , Adappa Nithin D. , Doghramji Laurel J. , Chiu Alexander G. , Lautenbach Ebbing , Cohen Noam A. , Palmer James N. 
Published: September 2014

BackgroundIt is unclear whether chronic rhinosinusitis (CRS) patients with both nasal polyps and asthma have different quality of life (QOL) improvement after functional endoscopic sinus surgery (FESS). We aimed to determine whether CRS patients with asthma and nasal polyps had a greater QOL improvement after FESS compared to patients without asthma or polyps.MethodsThis retrospective analysis included adult CRS patients who underwent FESS between 2007 and 2011. QOL was measured using the 22‐item Sino‐Nasal Outcome Test (SNOT‐22). Variables collected included baseline demographics, clinical factors, SNOT‐22 scores before FESS, and 1 month, 3 months, and 6 months post‐FESS. Groups tested were asthma alone, polyps alone, asthma and polyps, and no asthma or polyps. Linear mixed‐effects regression model was performed to calculate β‐coefficients, which represent the adjusted mean QOL differences.ResultsAmong the 376 patients included, 40.16% had both asthma and polyps (n = 151), 14.36% had asthma alone (n = 54), 19.45% had polyps alone (n = 75), and 25.53% had no asthma or polyps (n = 96). After adjusting for all factors, there were significantly more QOL improvements in patients with both asthma and nasal polyps from baseline to 1‐month (β‐coefficient = −10.05; 95% CI, −15.86 to −4.23; p = 0.001) and 3‐month follow‐up (β‐coefficient = −8.27; 95% CI, −14.98 to −1.56; p = 0.016), and patients with asthma alone from baseline to 6‐month follow‐up (β‐coefficient = −8.78; 95% CI, −17.45 to −0.11; p = 0.047), when compared to patients without asthma or nasal polyps.ConclusionCRS patients with both asthma and nasal polyps or asthma alone experience a larger QOL benefit from FESS immediately after FESS compared to CRS patients without asthma or polyps.
Steroid‐eluting sinus implant for in‐office treatment of recurrent polyposis: a pharmacokinetic study
Authors: Ow Randall , Groppo Eli , Clutter Donald , Gawlicka Anna K. 
Published: September 2014

BackgroundLong‐term use of systemic glucocorticoid therapy has been associated with hypothalamic‐pituitary‐adrenal axis suppression and other systemic adverse events. This pharmacokinetic study evaluated the systemic safety and performance of a bioabsorbable sinus implant that gradually releases 1350 μg of mometasone furoate directly to the sinus mucosa.MethodsA prospective, single‐center study treating 5 adult patients with recurrent polyposis after bilateral total ethmoidectomy. Each patient received 2 steroid‐releasing implants in‐office under local/topical anesthesia. Plasma concentrations of mometasone furoate and cortisol were determined before placement and through 30‐day follow‐up, which also included endoscopic grading and patient‐reported outcomes.ResultsFive patients (mean age 46.2 ± 9.2 standard deviation [SD] years; 60% male) underwent successful placement in all 10 ethmoid sinuses. There were no serious adverse events. The plasma concentrations of mometasone furoate were generally below the lower limit of quantification (LLOQ) of the assay (30 pg/mL). Cortisol concentrations at follow‐up ranged from 3.9 to 5.7 mg/dL compared to 4.7 mg/dL at baseline. At 1 month, there was a significant improvement in bilateral polyp grade (p = 0.037), nasal obstruction score (p = 0.002), and 22‐item Sino‐Nasal Outcome Test (SNOT‐22) (p = 0.010) compared to baseline.ConclusionThe reported 100% placement success, negligible systemic exposure to mometasone furoate released over time, lack of adrenal suppression, and the absence of serious adverse events suggest that the implant provides a valid and safe option for the in‐office treatment of recurrent polyposis. Randomized, controlled, blinded clinical studies are underway to provide further evidence of safety and efficacy.