bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Acute Generalized Exanthematous Pustulosis (AGEP) Possibly Induced by Iohexol
Authors: Atasoy Mustafa , Erdem Teoman , Sari Refik Ali 
Published: July 2014

AbstractAcute generalized exanthematous pustulosis (AGEP) is an uncommon disease manifested as an erythematous pustular eruption. It is usually caused by systemic medication. We describe a patient with acute generalized pustular eruption induced by iohexol. A 52‐year‐old woman developed fever and a generalized pustular eruption on the neck, trunk and extremities three days after taking iohexol. The culture from pustules was sterile. Other systemic and laboratory examinations were normal. A skin biopsy from a lesion on the trunk showed the features of a drug‐induced pustular eruption as a subcorneal blister including neutrophils and eosinophils, mild spongiosis, and a sparse infiltrate at neutrophils and eosinophils in the papillary dermis. The patient had no history of psoriasis. The lesions resolved with systemic corticosteroid therapy within one week and did not relapse. According to our investigation, iohexol‐induced AGEP has not been previously reported. We present an interesting case.
Nasal Natural Killer/T Cell Lymphoma with Cutaneous Involvement: Case Report and Chinese Literature Review Reported in China Mainland
Authors: Liu Jie , He Zhixin , Xie Yong , Fang Kai , Gao Zifen , Wang Baoxi 
Published: July 2014

AbstractNasal natural killer (NK)/T cell lymphoma is an Epstein‐Barr virus (EBV) associated lymphoma that arises in the nasal area and aggressively invades surrounding tissues. Our patient was a 48‐year‐old male who had had nasal obstruction and nasal discharge for 2 years and infiltrating plaques and necrosis on his nasal dorsum for three months. He developed fever and fatigue two weeks before admission. Biopsy from both skin and nasal mucosa revealed atypical medium‐sized tumor cells infiltrating into the dermis. Immunohistochemical studies revealed that the tumor cells were UCHL‐1, cytoplasmic CD3, CD56, TIA‐1, and granzyme B positive, and CD8 and CD20 negative. In situ hybridization for EBV‐DNA was positive. Clonal TCRβ and TCRγ gene rearrangement were negative. The patient was treated with cyclophosphamide, vincristine, and prednisone (COP) and with local radiotherapy, but he died 20 days later. We reviewed the cases of nasal NK/T cell lymphoma reported in mainland China in the Chinese literature during the last 5 years.
Tissue Parasites in Patients with Chronic Urticaria
Authors: Demirci Mustafa , Yildirim Mehmet , Aridogan Buket Cicioglu , Baysal Vahide , Korkmaz Metin 
Published: July 2014

AbstractChronic urticaria is an important diagnostic and therapeutic problem. We aimed to investigate the sero‐prevalence of tissue parasites causing toxocariasis and fasciolosis in patients with chronic urticaria. All cases were analyzed for antibodies against Toxocara canis and Fasciola hepatica by modified (homemade) ELISA. The excretory/secretory products of Toxocara and Fasciola were used as antigens (ES‐ELISA) in the test. In this study, the highest toxocariasis seropositivity (29.0%) rate and the highest fasciolosis seropositivity (14.5%) rate were found in patients with chronic urticaria. Fasciolosis seropositivity and total seropositivity of toxocariasis and fasciolosis in patients with chronic urticaria was significantly higher than in healthy controls (p<0.05). Toxocariasis seropositivity in patients with chronic urticaria was not significantly higher than that in healthy controls (p<0.05). We suggest that parasitic infections should be considered as an important cause of chronic urticaria. Serological methods should be used to expose the diagnosis of tissue parasites in such cases.
Iatrogenic Hypercalcemia Due to Vitamin D3 Ointment (1,24(OH)2D3) Combined with Thiazide Diuretics in a Case of Psoriasis
Authors: Kawaguchi Masakazu , Mitsuhashi Yoshihiko , Kondo Shigeo 
Published: July 2014

AbstractTacalcitol is a synthetic vitamin D3 analogue developed for topical treatment of inflammatory skin diseases such as psoriasis. Hypercalcemia has not been previously reported during treatment with topical tacalcitol. We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia. After initiation of topical vitamin D3 ointment (20 μg/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually. On day 28 of the treatment, his serum calcium levels had reached 3.55 mmol/l, and his urinary calcium excretion had also increased from 0.008 g/day to 0.475 g/day. The tacalcitol treatment was terminated, seven days later, the serum calcium level had returned to the reference range without any specific treatment. The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.
Churg‐Strauss Syndrome (CSS) Manifested as Necrosis of Fingers and Toes and Liver Infarction
Authors: Otani Yuichiro , Anzai Saburo , Shibuya Hiromi , Fujiwara Sakuhei , Takayasu Susumu , Asada Yuji , Terashi Hiroto , Takuma Masahisa , Yokoyama Shigeo 
Published: July 2014

AbstractWe report a case of Churg‐Strauss syndrome (CSS) with necrosis of the fingers and toes and liver infarction. A 59‐year‐old man with asthma suddenly noticed that his fingers and toes felt unusually cold. This condition worsened progressively, and some digits became necrotic within several weeks. Laboratory studies revealed hypereosinophilia and an extremely elevated serum level of IgE. Digital subtraction angiography of the extremities revealed extensive irregular narrowing of small and medium‐sized arteries in the extremities. Abdominal computed tomography (CT) revealed an area of low density at the periphery of the right lobe of the liver. Angiography revealed irregular narrowing of small arteries that corresponded to the ischemic area. A nerve conduction study suggested sensory nerve neuropathy. The preceding asthma, acute onset of digital necrosis, liver infarction, neuropathy, and hypereosinophilia strongly suggested a diagnosis of CSS. The patient was treated with 40 mg of prednisolone and 120 μg of intravenous prostaglandin E1 daily, and all the digits that had turned black and necrotic were amputated. After the amputation, the dose of prednisolone was gradually reduced, and no new lesions appeared on the skin or in the liver. The rare possible complications of CSS, including necrosis of digits and liver infarction, should not be ignored.
Lipoma of the Index Finger
Authors: Choi Hyoun‐Sung , Yi Ji‐Hyun , Kang Sung‐Ho , Yun Seok‐Kweon 
Published: July 2014

AbstractLipomas are common, benign tumors originating from adipose tissues. They can occur anywhere on the body but are rarely found on the finger. We report two lipomas of the right index finger in a 46‐year‐old man; this is the first report of a lipoma occurring on the fingers in Korea.
Eosinophilic Pustular Folliculitis Following Autologous Peripheral Blood Stem‐Cell Transplantation
Authors: Keida Tomoko , Hayashi Nobukazu , Kawashima Makoto 
Published: July 2014

AbstractWe describe a case of eosinophilic pustular folliculitis (EPF) occurring after autologous peripheral blood stem‐cell transplantation for non‐Hodgkin's lymphoma and successfully treated with oral and topical indomethacin. Including ours, the reported cases of EPF with HIV‐negative hematological disease have shown clinical features similar to those of HIV‐associated EPF, however the prognosis is better than that for HIV‐associated EPF, which usually shows a persistent course. EPF with HIV‐negative hematological disease can be classified as a unique group in EPF.
Eczema Herpeticum Localized to Area of Tinea Cruris
Authors: Kang Sung‐Ho , Yi Ji‐Hyun , Choi Hyoun‐Sung , Yun Seok‐Kweon 
Published: July 2014

AbstractEczema herpeticum (EH) has been reported in association with various skin abnormalities. We experienced a patient with tinea cruris who developed EH within a fungal infection. To our knowledge, dermatophyte infection as an underlying cutaneous disorder for EH has not been previously described in the English literature.
Characteristics of Skin Surface Morphology and Transepidermal Water Loss in Clinically Normal‐Appearing Skin of Patients with Atopic Dermatitis: A Video‐Microscopy Study
Authors: Suehiro Mitsuhiro , Hirano Shinya , Ikenaga Kenji , Katoh Norito , Yasuno Hirokazu , Kishimoto Saburo 
Published: July 2014

AbstractIn patients with atopic dermatitis (AD), it is debatable whether clinically normal‐appearing skin is equal to non‐atopic normal skin. The aim of this study was to quantitatively evaluate the characteristics of normal‐appearing skin of AD. We examined the value of skin surface morphological changes using a new, simple, computer‐assisted method with a video microscope. We also investigated the physiological function as represented by transepidermal water loss (TEWL) levels in 44 patients with AD and 15 normal controls. The morphological changes were represented by a variation coefficient score that reflected the irregularity of skin ridges, named the surface irregularity index (SII). There were significant differences between the normal‐appearing skin of AD and non‐atopic normal skin in both SII (P<0.001) and in TEWL (P<0.01). Especially for the SII, there were significant differences between AD subgroups subdivided by peripheral blood eosinophil count (Eo), serum lactate dehydrogenase level, and clinical score. TEWL values were significantly higher in the high‐Eo AD group (n=15) than in the low‐Eo AD group (n=29) (P<0.05). These findings indicate that clinically normal‐appearing skin of AD patients with high disease activity differs from non‐atopic normal skin in both surface morphology and physiology and that these changes reflect the current disease activity.
Clinical and Pharmacokinetic Studies of Continuous Itraconazole for the Treatment of Onychomycosis
Authors: Kawada Akira , Aragane Yoshinori , Tezuka Tadashi 
Published: July 2014

AbstractItraconazole, a triazole antifungal agent, has been widely used for onychomycosis with high cure rates. Unchanged itraconazole and a major metabolite hydroxy‐itraconazole reach the nail with a strong affinity for keratin. The aim of this study was to elucidate clinical effectiveness and pharmacokinetic profiles of a 6‐month continuous itraconazole treatment at a daily dose of 100 mg. Nail growth, the decrease in nail turbidity, and the nail concentrations of unchanged‐ and hydroxy‐itraconazole were investigated. The affected nails we examined demonstrated nail growth proportional to the decrease in turbidity and a quick increase in drug concentration with a long duration of a high concentration after cessation. Our results support the hypothesis that this continuous therapy is a good modality for onychomycosis.
Leprosy with Guillain Barre Syndrome: A New Neurologic Manifestation?
Authors: Grover Chander , Kubba Samir , Nanda Soni , Kumar Vijay , Reddy Belum Siva Nagi 
Published: July 2014

AbstractA 19‐year‐old female patient of lepromatous leprosy with Type II reaction, on multidrug therapy and prednisolone, presented with acute onset flaccid quadriparesis. The cerebrospinal fluid examination revealed albumino‐cytologic dissociation. Nerve biopsy showed infiltration with lepra bacilli, features of vasculitis, and demyelination. There were no other identifiable precipitating factors for Guillain Barre Syndrome in this patient. Her condition improved without any steroid therapy. This case emphasizes the hypothesis that cell injury caused by Type II reaction can expose neural antigens and incite an autoimmune reaction in the form of Guillain Barre Syndrome.
Giant Suspensory Lipoma with Calcification
Authors: Kinoshita Ryoko , Yasuda Hiroshi , Yamamoto Osamu , Tokura Yoshiki 
Published: July 2014

AbstractA seventy‐four‐year‐old woman presented with a giant lipoma suspended from her left upper arm. The surgically removed tumor weighed 2,600 g and included calcified areas in its periphery. Our histologic observations suggested that the calcification was generated in association with degenerated fat.
Peripheral Neuropathy in Behçet's Disease
Authors: Birol Ahu , Ulkatan Sedat , Koçak Mukadder , Erkek Emel 
Published: July 2014

AbstractBehçet's disease (BD) is a multisystem disorder. Since its first description, the involvement of many organ‐systems has been studied. However, the involvement of the peripheric nervous system has not been well documented yet. Twenty‐six patients involved in the study were without prominent complaints of neuropathic symptoms. They were surveyed through the outpatient clinic of the department of dermatology. Each patient filled out a total neuropathy score (TNS) questionaire after their neurologic exam. A neurology specialist conducted the electrophysiological study. Our results were noteworthy because this complication was present without significant complaint. We hypothesized that the nerve dysfunction or peripheral neuropathy of BD is an axonal type of distal polyneuropathy and predominantly involves the lower extremities. We did not find a predominant motor or sensory nerve involvement. This complication is mentioned and reported rarely in BD.
A Case of Varicella‐Associated Idiopathic Thrombocytopenic Purpura in Adulthood
Authors: Hamada Manabu , Yasumoto Shinichiro , Furue Masutaka 
Published: July 2014

AbstractWe describe here an adult case of varicella‐associated idiopathic thrombocytopenic purpura (ITP). A 23‐year‐old Japanese male presented with generalized hemorrhagic vesicles and fever. Laboratory examinations revealed severe thrombocytopenia associated with anti‐platelet IgG auto‐antibody. The patient rapidly recovered within a few days after antiviral agent (vidarabine) administration, and the platelet count returned to normal with skin lesion improvement. Idiopathic thrombocytopenic purpura associated with viral infection in adulthood is relatively rare.
A Case of Persistent Subepidermal Calcified Nodule in an Adult Treated with CO2 Laser
Authors: Joo Young Hyun , Kwon In Ho , Huh Chang Hun , Park Kyoung Chan , Youn Sang Woong 
Published: July 2014

AbstractA subepidermal calcified nodule (SCN) is an uncommon form of calcinosis cutis that is not associated with other dermatologic or systemic illnesses. Clinically, SCN presents as a solitary, firm tumor that can be white, white‐yellow, or erythematous. Most SCNs occur in children; they are extremely rare in adults. The treatment of choice is believed to be surgical excision. We describe a case of SCN on the right ear lobe of a 33‐year‐old male, which was treated using a CO2 laser and electrodessication.
Acrogeria with Decreased Gene Expression of α1(I) and α1(III) Collagen in Cultured Dermal Fibroblasts
Authors: Wu Jinghai , Hatamochi Atsushi 
Published: July 2014

AbstractWe report a case of acrogeria. A 47‐year‐old Japanese man presented with micrognathism, thin lips, radial wrinkles around his month, atrophy of skin and subcutaneous tissue, and mottled hyperpigmentation on his extremities. A biopsy of the lesional skin showed flat epidermis and atrophy of the dermal layer. The in vitro life span of the patient's fibroblasts (18 ± 2.2 PDL) was significantly shorter than that of control fibroblasts (42 ± 3.5 PDL). The early‐passage fibroblasts from the patient showed abnormal morphology which was also seen in the late‐passage (in vitro aging) of normal fibroblasts. In northern blotting analysis of cultured dermal fibroblasts, mRNA levels of α1(I) collagen and α1 (III) collagen were markedly reduced. These results revealed that patient fibroblasts might be in severe senescence in vitro and contribute to the phenotypes of this premature aging syndrome.
The Lesional Skin of Linear IgA Bullous Dermatosis Expresses Growth‐Regulated Peptide (GRO)‐α
Authors: Tsunemi Yuichiro , Ihn Hironobu , Saeki Hidehisa , Tamaki Kunihiko 
Published: July 2014

AbstractThe patient was a 62‐year‐old man with erythema with tense vesiculobullae and erosions on the bilateral elbows, right knee, and one buttock. A skin biopsy specimen revealed subepidermal blister formation with a predominant infiltration of neutrophils and papillary neutrophilic microabscesses. Direct immunofluorescence study showed linear deposition of IgA and weak deposition of IgG at the basement membrane zone of the lesional skin, and indirect immunofluorescence study showed linear deposition of IgA at the epidermal side of the 1M NaCl‐separated normal skin. He was diagnosed with linear IgA bullous dermatosis. Immunohistochemical study revealed that the lesional and perilesional keratinocytes expressed growth‐regulated peptide (GRO) ‐α, a potent chemoattractant for neutrophils. This suggests that GRO‐α plays a role in the infiltration of neutrophils into the lesional skin and in bulla formation in linear IgA bullous dermatosis.
A Case of Symmetrical Leukemia Cutis on the Eyelids Complicated by B‐Cell Chronic Lymphocytic Lymphoma
Authors: Ikeda Takaharu , Sakurane Mikihisa , Uede Koji , Furukawa Fukumi 
Published: July 2014

AbstractWe describe herein a case of symmetrical bilateral leukemia cutis on the eyelids, especially on the lower lids, in a patient with B‐cell chronic lymphocytic leukemia (CLL). The patient was a 63‐year‐old Japanese man who had been diagnosed with CLL. Eyelid swelling is well known to result from local skin or systemic diseases including tumors, hyperthy‐roidism, nephritic syndrome, and hypoalbuminemia. To our knowledge, symmetrical, bilateral, flesh‐colored leukemia cutis on the eyelids has not been previously reported.
A Case of Bowen's Disease Showing a Clinical Tendency Toward Spontaneous Regression
Authors: Nihei Nozomi , Hiruma Masataro , Ikeda Shigaku , Ogawa Hideoki 
Published: July 2014

AbstractWe present a case of Bowen's disease showing a clinical tendency toward spontaneous regression. The patient, a healthy 86‐year‐old woman, complained that erythema had appeared on her left forearm two years earlier and had gradually enlarged. At the first examination, we observed a well‐demarcated, 4 × 3 cm, erythematous plaque, partically covered with crusting and erosions near the wrist. Diagnosis of Bowen's disease was confirmed by a biopsy. Since the patient refused surgery and also discontinued hyperthermic treatment with disposable chemical pocket warmers after a brief trial, we decided to continue the observation of disease progression without any treatment. Two years after the initial visit, the lesion showed a clinical tendency toward spontaneous regression, with a fine erythematous plaque that showed the obscurely demarcated border of the lesion. After three years, although the patient exhibited a similar symptomatic improvement, a skin biopsy showed a few residual tumor cells. At the patient's request, we chose to observe the progress of the lesion. We review the literature of cases of Bowen's disease that have shown a similar tendency toward spontaneous regression, which have been rare.
Macrolactam Immunomodulators (Tacrolimus and Pimecrolimus): New Horizons in the Topical Treatment of Inflammatory Skin Diseases
Authors: Grunwald Marcelo H. , Amitai Dan Ben , Amichai Boaz 
Published: July 2014

AbstractTacrolimus and pimecrolimus are new macrolactam immunomodulators which were developed for the treatment of inflammatory skin diseases, mainly atopic dermatitis. In this article, we review the pharmacologic properties of the drugs, their side effects, and their clinical uses.
Efficiency of Benzoyl Peroxide‐Erythromycin Gel in Comparison with Metronidazole Gel in the Treatment of Acne Rosacea
Authors: Öztürkcan Serap , Ermertcan Aylin Türel , Şahin M. Turhan , Afşar F. Şule 
Published: July 2014

AbstractOral wide‐spectrum antibiotics are the linchpin of rosacea treatment. Oral and topical metronidazole, topical tretinoin, and topical benzoyl peroxide may also be used in the treatment of rosacea. We aimed to show that benzoyl peroxide‐erythromycin gel is efficient in the treatment of acne rosacea. Fifty‐six patients with acne rosacea were enrolled in our study. We administered benzoyl peroxide‐erythromycin gel to 27 patients and metronidazole gel to 29 patients. In all the patients, the intensities of erythema, telangiectasia, papules/pustules, and nodules were evaluated before, during and after the treatment. The positivity of Demodex folliculorum from skin scratches was compared between the two groups at each visit. At the end of the therapy on the third examination, in the benzoyl peroxide‐erythromycin group, 91.7% of the patients showed marked clinical improvement, and 8.3% of them showed complete remission. In the metronidazole group, 73.3% showed marked clinical improvement, and 26.7% of them showed complete remission. Clinical improvement in the papular component was 65.2% for the benzoyl peroxide‐erythromycin group, and 81.5% for metronidazole group. In the first examination, the clinical results of the agents were similar. Although both of the drugs were found to be effective in the second and third examinations, metronidazole gel was more effective than benzoyl peroxide‐erythromycin. Both of the drugs were found to be significantly effective especially in treating the papular component of rosacea. Demodex folliculorum was found to be positive in 74.1% of the benzoyl peroxide‐erythromycin group and in 62.1% of the metronidazole group at the beginning. In the benzoyl peroxide‐erythromycin group, 40.7% of Demodex folliculorum positive patients, became negative by the first examination. This was 17.2% for the metronidazole group. In the benzoyl peroxide‐erythromycin group, among the patients who were positive for Demodex folliculorum in the first examination, 37.5% of them became negative. This was 36.7% for the metronidazole group. Benzoyl peroxide‐erythromycin gel was superior to metronidazole gel in decreasing Demodex folliculorum by the first examination, but the effect of the two drugs on Demodex folliculorum was similar by the second examination. As a result, topically applied combined benzoyl peroxide‐erythromycin gel may be an alternative choice of treatment for acne rosacea.