bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fundamental movement skills in preschoolers: a randomized controlled trial targeting object control proficiency
Authors: Donath L. , Faude O. , Hagmann S. , Roth R. , Zahner L. 
Published: February 2015

AbstractBackgroundAdequately developed fundamental movement skills, particularly object control dimensions, are considered essential to learn more complex movement patterns and to increase the likelihood to successfully participate in organized and non‐organized sports during later years. Thus, the present randomized controlled trial aimed at improving object control dimensions at an early state in a kindergarten setting.MethodsCatching, throwing, kicking, rolling and stationary dribbling were assessed via gross motor development 2 (TGMD‐2) testing in 41 normally developed preschoolers. On a cluster‐randomized basis [strata: age, sex and body mass index (BMI)], three kindergartens were randomly assigned to an intervention group (n = 22, INT, age: 4.6 ± 1.0 years; BMI: 16.2 ± 1.1 kg/m2) and three to a control group (n = 19, CON: age: 4.5 ± 1.2 years; BMI: 16.8 ± 1.2 kg/m2). Twelve structured training sessions were given within 6 weeks (12 sessions). The total training volume was 330 min.ResultsModerate time × group interaction were observed for the total sum score (Δ+22%, P = 0.05) and dribbling (Δ+41%, P = 0.002). Adjusting for baseline differences analyses of covariance did not affect these results. Interestingly, likely to most likely practically worthwhile effects were detected for the total sum score, catching and dribbling.ConclusionObject control dimensions such as dribbling and catching that apparently rely on rhythmical movement patterns and anticipatory eye‐hand coordination seem to benefit from short‐term object control training. These skills are considered important for successful team‐sport participation and appropriate sportive motor development.
Prognostic value of circulating CD133+ cells in patients with gastric cancer
Authors: Xia Pu , Song Chang‐Liang , Liu Jin‐Fang , Wang Dan , Xu Xiao‐Yan 
Published: February 2015

AbstractObjectivesGastric cancer is an important cause of cancer‐related mortality worldwide (1). There is increasing evidence that the existence of cancer stem cells (CSC) is responsible for tumour formation and maintenance.Materials and methodsThe present study was designed to recognise circulating CSCs from blood samples of patients with gastric cancer, using CD133 and ABCG2 as potential markers. CD133−, CD133+ ABCG2− and CD133+ ABCG2+ cells lines were analysed by flow cytometry, immunofluorescence staining, western blotting and real‐time PCR. Furthermore, functional assays (clonogenic assay in vitro and tumourigenic assay in vivo) were also performed using these cell lines.ResultsHigher percentages of CD133+ cells were identified in blood samples from gastric cancer patients compared to normal controls. In addition, we found by using Kaplan–Meier analysis, that numbers of CD133+ cells correlated with poor prognosis gastric cancer patients. Finally, tumourigenic properties of CD133+ ABCG2+ cells were determined in vitro and in vivo.ConclusionsOur in vitro and in vivo experiments demonstrated that CD133+ ABCG2+ cells exhibited well‐known CSC characteristics; thus when circulating they could be used as a prognostic marker for gastric cancer.
Kombinierte operative Therapie eines Zangennagels (pincer nail) mit Matrixverödung, Nagelspaltung und Schienung
Authors: Markeeva Evgenia , Hinterberger Louisa , Vogt Thomas , Rass Knuth 
Published: February 2015

ZusammenfassungZangennägel oder pincer nails (engl.: pincer, Kneifzange; auch: Röhrennägel) stellen eine seltene Nageldeformität dar. Durch eine hyperkonvexe Nagelkrümmung, die entlang der Longitudinalachse nach distal zunimmt, kommt es zu einem „kneifzangenartigen“ Einfassen des Nagelbetts. Pincer nails (PN) können ein‐ oder beidseitig an Finger‐ und/oder Zehennägel auftreten, es können mehrere oder auch alle Nägel betroffen sein. Die häufigste Ursache für Röhrennägel sind im Bereich der Füße zu enge Schuhe und im Bereich der Hände degenerative Veränderungen der Fingergelenke.Die Therapie von PN beinhaltet konservative und operative Methoden. Zu den konservativen Methoden gehört das Aufweichen der Nagelplatte mit 40%igem Harnstoff. Weniger ausgeprägte Deformationen können mit Metall‐ oder Kunststoffspangen korrigiert werden. Bei ausgeprägten oder therapieresistenten Fällen kommen operative Verfahren zum Einsatz wie die seitliche Verschmälerung der Nagelplatte mit oder ohne Verödung des Nagelbettes. Ferner ist auch eine Verbreiterung des Nagelbetts durch Abtragen eines ggf. vorhandenen Osteophyten beschrieben.Wir stellen die operative Behandlung eines PN des rechten Daumens durch bilaterale Nagelresektion, Verödung der Nagelmatrix mit Trichloressigsäure und medianer Nagelspaltung mit konsekutiver Nagelschienung vor.
Risikofaktoren für ein vermindertes Ansprechen in der Behandlung des Erysipels
Authors: Linke Miriam , Booken Nina 
Published: February 2015

ZusammenfassungHintergrundDas Erysipel kann in den meisten Fällen mittels der initialen antibiotischen Therapie adäquat behandelt werden. Allerdings wird der Kliniker immer wieder mit komplizierten Verläufen dieser Erkrankung, in denen die Patienten nicht auf die initiale Antibiose ansprechen, konfrontiert. Ziel dieser Arbeit war es, Risikofaktoren zu detektieren, die mit einem verminderten Ansprechen der Therapie und damit mit einem komplizierteren Behandlungsverlauf assoziiert sind.Patienten und MethodikEs erfolgte eine retrospektive Auswertung von 98 Patienten mit einem Erysipel, die mit einer Standardtherapie stationär behandelt wurden. Wir führten einen Vergleich der Patientengruppen mit einem unterschiedlichen Ansprechen des Erysipels bezüglich deren klinischer Gesichtspunkte, Vorerkrankungen und Laborparameter durch.ErgebnissePatienten mit einem bullösen oder hämorrhagischen Erysipel (p = 0,0008), mit einer Stauungsdermatitis (p = 0,01) sowie einer chronisch venösen Insuffizienz (p = 0,0004) zeigten ein signifikant vermindertes Ansprechen auf das initiale Therapieschema bestehend aus einer Monotherapie mit Cefuroxim bzw. Clindamycin. Des Weiteren zeigte sich eine signifikante Abhängigkeit der Ansprechrate auf die initiale Therapie bezogen auf die Höhe des C‐reaktiven Proteins (p = 0,007) und der neutrophilen Granulozyten (p = 0,02).SchlussfolgerungBei Patienten mit einem klinisch komplizierten Erysipel, erhöhten laborchemischen Parametern oder einer bestehenden lokalen Vorschädigung ist zu diskutieren, diese Patienten nach einem forcierteren Antibiotikaschema zu behandeln.
Beliefs, perceptions and psychosocial impact of acne amongst Singaporean students in tertiary institutions
Authors: Su Peiqi , Chen Wee Aw Derrick , Lee Siew Hui , Han Sim Toh Matthias Paul 
Published: February 2015

SummaryBackgroundAcne vulgaris is a common skin condition which can have a negative impact on a patient's quality of life.Patients and MethodsA survey was distributed among students at tertiary institutions. Data was collected on participants’ own rating of acne grade and how acne affected their social life. A clinician on‐site graded the participants’ acne.ResultsOf the 429 students who participated in the survey, 59.8 % felt embarrassed or self‐conscious because of their acne. There was a low but statistically significant correlation (Spearman's Correlation Coefficient = 0.471, p < 0.001) between participants’ and clinicians’ grading of acne.ConclusionsAcne vulgaris causes a considerable amount of psychosocial stress. There are unfounded beliefs surrounding acne and unawareness of treatment options available.
Vorstellungen, Wahrnehmung und psychosoziale Auswirkungen von Akne bei singapurischen Hochschulstudenten
Authors: Su Peiqi , Wee Aw Derrick Chen , Hui Lee Siew , Han Sim Toh Matthias Paul 
Published: February 2015

ZusammenfassungHintergrundAcne vulgaris ist eine häufige Hauterkrankung, die negative Auswirkungen auf die Lebensqualität des Patienten haben kann.Patienten und MethodikUnter Hochschulstudenten wurde eine Umfrage durchgeführt. Die Daten wurden mittels Selbsteinschätzung der Patienten in Bezug auf den Schweregrad ihrer Akne wie auch auf die möglichen Auswirkungen ihrer Akne auf ihr gesellschaftliches Leben erhoben. Ein Klinikarzt vor Ort stufte den Schweregrad der Akne ein.Ergebnisse59,8 % der insgesamt 429 an der Umfrage teilnehmenden Studenten schämten sich aufgrund ihrer Akne oder fühlten sich ihretwegen gehemmt. Zwischen der Einstufung des Aknegrades durch die Teilnehmer selbst und der der Klinikärzte konnte eine niedrige, aber statistisch relevante Korrelation (Spearman‘s Korrelationskoeffizient = 0,471, p < 0.001) festgestellt werden.SchlussfolgerungenAcne vulgaris verursacht beträchtlich hohen psychosozialen Stress. Rund um den Begriff der Akne existieren gegenstandslose Vorstellungen, ebenso besteht eine Unwissenheit über mögliche, verfügbare Therapieoptionen.
Personality and overweight in 6–12‐year‐old children
Authors: Hampson S. E. , Vollrath M. E. , Júlíusson P. B. 
Published: February 2015

SummaryBackgroundPersonality may be an important yet understudied influence on childhood obesity.ObjectiveWe investigated the association between children's personality traits and weight status in a sample of 1533 6–12 year olds.MethodsMothers rated their child's personality using the Norwegian Hierarchical Personality Inventory for Children, and reported on their child's height and weight.ResultsRelative to their normal weight peers, overweight children were rated lower on energy, optimism, compliance, concentration, perseverance, and self‐confidence, and higher on egocentricity, irritability, and anxiety.ConclusionsThese findings suggest possible mechanisms to investigate in future research relating personality to childhood obesity.
Pannenberg, Particularity and Eschatology: Shifting the Debate
Authors: Tonstad Linn Marie 
Published: February 2015

AbstractWolfhart Pannenberg's account of the eschatological transition in his Systematic Theology describes how human beings are transformed by passing through a purifying fire that destroys whatever in them is incompatible with the life of God. I argue that this representation of human transformation renders individual existence too discontinuous between life as it now is and the life to come, makes redeemed interhuman sociality unimportant, and transforms access to salvation for non‐Christians into a matter of works. As a result, Pannenberg cannot preserve the kind of particularity he needs for his own theological aims: ensuring the significance of history, affirming finitude and developing a non‐oppositional understanding of the relation between the finite and the infinite.
Pouched Mitral Isthmus Is Associated with Incomplete Linear Block in Atrial Fibrillation Patients with Mechanical Mitral Valve Replacement
Authors: DENG WEN‐NING , CHEN KE , BAI RONG , ZHANG ZHI‐JUN , LI SONG‐NAN , WEN ZHAO‐YING , ZHANG CHEN , YU RONG‐HUI , LONG DE‐YONG , TANG RI‐BO , SANG CAI‐HUA , LIU NIAN , GUO XUE‐YUAN , WU XIAO‐YAN , NIE JUN‐GANG , DU XIN , DONG JIAN‐ZENG , MA CHANG‐SHENG 
Published: February 2015

Pouched Mitral Isthmus and Ablation BlockBackgroundPrevious studies have described the impact of mitral isthmus (MI) anatomy on the likelihood of achieving MI linear block in patients with native mitral valves (NMV) who underwent atrial fibrillation (AF) ablation. However, none have investigated that issue in AF patients with mechanical mitral valve replacements (MMVR).Methods and ResultsTwenty‐nine consecutive patients who developed symptomatic persistent AF post‐MMVR and referred for ablation were enrolled. Twenty‐nine patients with NMV who underwent ablation of persistent AF during the same period were matched. With preprocedural cardiac computed tomographic imaging, MI anatomical features of all the participants were analyzed. Pouched MI was observed in 19 (65.5%) MMVR patients versus to 6 (20.7%) controls (P = 0.001). Bidirectional linear block across MI was achieved in 21 (72.4%) MMVR patients and 22 (75.9%) in the controls (P = 0.764). In the multivariable analysis, pouched MI was an independent predictor of incomplete MI block.ConclusionsPouched MI accounts for the majority of AF patients with MMVR and may be associated with incomplete bidirectional linear block of MI.
Eumycetoma and actinomycetoma – an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy
Authors: Nenoff P. , van de Sande W.W.J. , Fahal A.H. , Reinel D. , Schöfer H. 
Published: February 2015

AbstractMycetoma is a chronic putrid infection of the cutaneous and subcutaneous tissue concerning predominantly the feet, and more rarely other body parts. Mycetoma can be caused by both fungi (eumycetoma) and bacteria (actinomycetoma). Mode of infection is an inoculation of the causative microorganism via small injuries of the skin. The clinical correlate of both forms of mycetoma is tumescence with abscesses, painless nodules, sinuses and discharge. The latter is commonly serous‐purulent and contains grains (filamentous granules) which can be expressed for diagnostic purposes. Distinctive for both eumycetoma and actinomycetoma, are the formation of grains. Grains represent microcolonies of the microorganism in vivo in the vital tissue. The most successful treatment option for eumycetomas offers itraconazole in a dosage of 200 mg twice daily. This triazole antifungal is considered as ‘gold standard’ for eumycetomas. Alternatively, the cheaper ketoconazole was widely used, however, it was currently stopped by the FDA. Actinomycetomas should be treated by the combination of trimethoprim‐sulphamethoxazole (co‐trimoxazole 80/400 to 160/800 mg per day) and amikacin 15 mg/kg body weight per day. Mycetomas are neglected infections of the poor. They are more than a medical challenge. In rural areas of Africa, Asia and South America mycetomas lead to socio‐economic consequences involving the affected patients, their families and the society in general.
The effects of systematic educational interventions about nasogastric tube feeding on caregivers' knowledge and skills and the incidence of feeding complications
Authors: Chang Shu‐Chen , Huang Chin‐Yi , Lin Ching‐Hsiung , Tu Shu‐Ling , Chao Mei‐Shih , Chen Mei‐Hua 
Published: February 2015

Aims and objectivesTo compare the influence of a systematic nursing intervention on primary caregivers' knowledge and skills about nasogastric tube feeding and the number of nasogastric tube‐related complications with that of routine nursing instructionsBackgroundTo ensure the quality of care and reduce the incidence of complications, it is crucial that primary caregivers receive comprehensive health education about nasogastric tube feeding before hospital discharge.DesignA quasi‐experimental research with pretest/post‐test evaluations.MethodsThe control group included 127 inpatients whose caregivers received routine education about nasogastric tube feeding, while the experimental group included 106 inpatients whose caregivers received systematic nursing intervention including comprehensive educational pamphlets and video education. The evaluation questionnaire included demographic variables, a nasogastric tube care knowledge scale, and a nasogastric tube skills assessment scale. The post‐test was administered after the caregiver performed nasogastric tube feeding for the first time, and complications were noted at follow‐up within three months of discharge.ResultsIn terms of post‐test knowledge and skills, the experimental group scored significantly higher than the control group, despite no difference in the pretests. In addition, the incidence rates for constipation, diarrhoea and abdominal distention were lower in the experimental group.ConclusionsSystematic nursing intervention, including comprehensive educational pamphlets and video education, significantly improved the knowledge and skills of primary caregivers for nasogastric tube feeding. The increased ability of caregivers may have contributed to less incidence of complication.Relevance to clinical practiceThe results of this study underlined the importance of developing nasogastric tube‐related nursing interventions and educational strategies for clinical nurses, home care nurses and caregivers. The research tool used here may serve as a reference for assessing the technical operations of healthcare professionals and the knowledge and skills of caregivers.
Individual Differences in Accurately Judging Personality From Text
Authors: Hall Judith A. , Goh Jin X. , Mast Marianne Schmid , Hagedorn Christian 
Published: February 2015

AbstractThis research examines correlates of accuracy in judging Big Five traits from first‐person text excerpts. Participants in six studies were recruited from psychology courses or online. In each study, participants performed a task of judging personality from text and performed other ability tasks and/or filled out questionnaires. Participants who were more accurate in judging personality from text were more likely to be female; had personalities that were more agreeable, conscientious, and feminine, and less neurotic and dominant (all controlling for participant gender); scored higher on empathic concern; self‐reported more interest in, and attentiveness to, people's personalities in their daily lives; and reported reading more for pleasure, especially fiction. Accuracy was not associated with SAT scores but had a significant relation to vocabulary knowledge. Accuracy did not correlate with tests of judging personality and emotion based on audiovisual cues. This research is the first to address individual differences in accurate judgment of personality from text, thus adding to the literature on correlates of the good judge of personality.
Comparison between Ki‐67 index and mitotic index for predicting outcome in canine mast cell tumours
Authors: van Lelyveld S. , Warland J. , Miller R. , Maw H. , Foale R. , Goodfellow M. , Dobson J. 
Published: February 2015

OBJECTIVESTo assess correlation between Ki67 index and mitotic index and determine which more accurately predicts survival in canine mast cell tumours.METHODSRetrospective analysis of cases from threeUKreferral hospitals. Correlation between Ki67 index and mitotic index was assessed and survival analysis performed.RESULTSA total of 162 dogs were included: 57 dogs died with 37 due to mast cell tumour. Correlation between Ki67 index and mitotic index was moderate, while the agreement was poor. A high Ki67 index was considered sensitive (86 · 5%) at predicting mast cell tumour‐related death, but poorly specific (57 · 9%). Mitotic index(>5) was poorly sensitive (32 · 4%), but highly specific (96%). A mitotic index ofê2 had a 75 · 7% sensitivity and an 80 · 0% specificity. Ki67 index showed a statistically significant survival difference within the mitotic index <2 (P = 0 · 009) group. Ki67 index did not predict survival rate in tumours with mitotic index ofê2.CLINICAL RELEVANCECorrelation between Ki67 and mitotic index is moderate. High mitotic index accurately predicted death, but many dogs with low mitotic index also died. Low Ki67 accurately predicted survival, but high Ki67 should not be considered a poor prognostic indicator. A three‐tier mitotic index assessment may more accurately predict death due to mast cell tumour.
Allergenicity of pasteurized whole raw Hen's egg compared with fresh whole raw Hen's egg
Authors: Netting Merryn , Donato Adaweyah , Makrides Maria , Gold Michael , Quinn Patrick , Penttila Irmeli 
Published: February 2015

AbstractBackgroundOral food challenges for diagnosis and management of egg allergy using fresh egg are common; however, to limit the risk of foodborne infection, many allergy units use pasteurized raw egg. Pasteurization and drying processes have the potential to affect the structure of egg proteins in egg powder and thus the allergenicity when compared to fresh egg. Our aim was to compare the binding of serum IgE from egg‐allergic children to in vitro digested and undigested pasteurized whole raw egg powder with unpasteurized fresh whole raw egg.MethodsEgg proteins from in vitro digested or undigested pasteurized whole raw egg powder, fresh whole egg, egg white and egg yolk were separated by SDS‐PAGE, transferred onto nitrocellulose membrane and incubated overnight with pooled sera from egg‐allergic children.ResultsIn both the raw egg samples and the pasteurized whole egg powder, protein bands corresponding to known molecular weights of the major egg allergens were present. Pasteurized whole raw egg powder was bound by serum IgE in a similar manner to unpasteurized whole raw egg and was unaffected by in vitro digestion. Serum IgE also bound egg yolk, indicating sensitization to both egg yolk and egg white proteins.ConclusionsThe main egg allergens are present in pasteurized whole raw egg powder, and serum IgE of egg‐allergic children binds to them in a similar pattern to those in fresh whole raw egg. Pasteurized whole raw egg powder is a suitable substitute for raw egg in clinical practice for oral food challenges.
Lung function following very preterm birth in the era of ‘new’ bronchopulmonary dysplasia
Authors: Simpson Shannon J. , Hall Graham L. , Wilson Andrew C. 
Published: February 2015

AbstractOne of the most significant complications of preterm birth is bronchopulmonary dysplasia (BPD). The pathophysiology of BPD has changed in recent years as advances in neonatal care have led to increased survival of smaller, more preterm, infants who display alterations to alveolar and pulmonary microvascular development. It is becoming clear that infants with ‘new’ BPD experience lung disease that persists into later childhood, however, the oldest of these children are just now entering young adulthood and therefore the longer term pulmonary implications remain unknown. The role of lung function testing in the identification and subsequent management of patients with lung disease resulting from a neonatal classification of BPD is reviewed based on the underlying pathophysiology of the disease.
Determination of HLA‐A, ‐C, ‐B, ‐DRB1 allele and haplotype frequency in Japanese population based on family study
Authors: Ikeda N. , Kojima H. , Nishikawa M. , Hayashi K. , Futagami T. , Tsujino T. , Kusunoki Y. , Fujii N. , Suegami S. , Miyazaki Y. , Middleton D. , Tanaka H. , Saji H. 
Published: February 2015

AbstractThe present study investigates the human leucocyte antigen (HLA) allele and haplotype frequencies in Japanese population. We carried out the frequency analysis in 5824 families living across Japanese archipelago. The studied population has mainly been typed for the purpose of transplant, especially the hematopoietic stem cell transplantation (HSCT). We determined HLA class I (A, B, and C) and HLA class II (DRB1) using Luminex technology. The haplotypes were directly counted by segregation. A total of 44 HLA‐A, 29 HLA‐C, 75 HLA‐B, and 42 HLA‐DRB1 alleles were identified. In the HLA haplotypes of A‐C‐B‐DRB1 and C‐B, the pattern of linkage disequilibrium peculiar to Japanese population has been confirmed. Moreover, the haplotype frequencies based on family study was compared with the frequencies estimated by maximum likelihood estimation (MLE), and the equivalent results were obtained. The allele and haplotype frequencies obtained in this study could be useful for anthropology, transplantation therapy, and disease association studies.