bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bipolar Textile Composite Electrodes Enabling Flexible Tandem Solid‐State Lithium Metal Batteries
Authors: Wei Zhenyao , Luo Yufeng , Yu Wancheng , Zhang Yufei , Cai Jiehua , Xie Chuan , Chang Jian , Huang Qiyao , Xu Xiaoxiong , Deng Yonghong , Zheng Zijian 
Published: July 2024

AbstractA majority of flexible and wearable electronics require high operational voltage that is conventionally achieved by serial connection of battery unit cells using external wires. However, this inevitably decreases the energy density of the battery module and may cause additional safety hazards. Herein, a bipolar textile composite electrode (BTCE) that enables internal tandem‐stacking configuration to yield high‐voltage (6 to 12 V class) solid‐state lithium metal batteries (SSLMBs) is reported. BTCE is comprised of a nickel‐coated poly(ethylene terephthalate) fabric (NiPET) core layer, a cathode coated on one side of the NiPET, and a Li metal anode coated on the other side of the NiPET. Stacking BTCEs with solid‐state electrolytes alternatively leads to the extension of output voltage and decreased usage of inert package materials, which in turn significantly boosts the energy density of the battery. More importantly, the BTCE‐based SSLMB possesses remarkable capacity retention per cycle of over 99.98% over cycling. The composite structure of BTCE also enables outstanding flexibility; the battery keeps stable charge/discharge characteristics over thousands of bending and folding. BTCE shows great promise for future safe, high‐energy‐density, and flexible SSLMBs for a wide range of flexible and wearable electronics.
Advancements and Perspectives in Folate‐Based Anticancer Drugs: Bridging Quantum and Classical Mechanics in Folate Receptor Research
Authors: Josiah Andrea Jess , Govender Krishna Kuben , Govender Penny Poomani , Sinha Ray Suprakas 
Published: July 2024

AbstractThis review highlights the role of computational chemistry, specifically quantum and molecular mechanics, in the development of folate‐based anticancer drugs. Folate receptors (FRs) are overexpressed in cancerous cells, rendering these receptors a key focus in the design of targeted drug delivery systems. These computational tools are fundamental for analyzing drug–receptor interactions and overcoming the limitations of traditional drug development processes. A 10‐year literature survey demonstrated advancements in employing FRs for targeted cancer therapy. Key findings reveal that structural modifications to folate derivatives consistently enhance binding affinities and specificity toward FRα and FRβ. Computational methodologies predicted and analyzed molecular interactions, validated by experimental data. Functional groups play a crucial role in enhancing binding stability and interaction strength within FR binding pockets. Detailed structural insights into folate derivatives and antifolates interacting with FRs have identified critical residues involved in binding, aiding the design of targeted therapeutics.
Double Imprinted Nanoparticles for Sequential Membrane‐to‐Nuclear Drug Delivery
Authors: Singla Pankaj , Broughton Thomas , Sullivan Mark V. , Garg Saweta , Berlinguer‐Palmini Rolando , Gupta Priyanka , Smith Katie J , Gardner Ben , Canfarotta Francesco , Turner Nicholas W. , Velliou Eirini , Amarnath Shoba , Peeters Marloes 
Published: July 2024

AbstractEfficient and site‐specific delivery of therapeutics drugs remains a critical challenge in cancer treatment. Traditional drug nanocarriers such as antibody‐drug conjugates are not generally accessible due to their high cost and can lead to serious side effects including life‐threatening allergic reactions. Here, these problems are overcome via the engineering of supramolecular agents that are manufactured with an innovative double imprinting approach. The developed molecularly imprinted nanoparticles (nanoMIPs) are targeted toward a linear epitope of estrogen receptor alfa (ERα) and loaded with the chemotherapeutic drug doxorubicin. These nanoMIPs are cost‐effective and rival the affinity of commercial antibodies for ERα. Upon specific binding of the materials to ERα, which is overexpressed in most breast cancers (BCs), nuclear drug delivery is achieved via receptor‐mediated endocytosis. Consequentially, significantly enhanced cytotoxicity is elicited in BC cell lines overexpressing ERα, paving the way for precision treatment of BC. Proof‐of‐concept for the clinical use of the nanoMIPs is provided by evaluating their drug efficacy in sophisticated three‐dimensional (3D) cancer models, which capture the complexity of the tumor microenvironment in vivo without requiring animal models. Thus, these findings highlight the potential of nanoMIPs as a promising class of novel drug compounds for use in cancer treatment.
DCAF7 Acts as A Scaffold to Recruit USP10 for G3BP1 Deubiquitylation and Facilitates Chemoresistance and Metastasis in Nasopharyngeal Carcinoma
Authors: Li Qing‐Jie , Fang Xue‐Liang , Li Ying‐Qin , Lin Jia‐Yi , Huang Cheng‐Long , He Shi‐Wei , Huang Sheng‐Yan , Li Jun‐Yan , Gong Sha , Liu Na , Ma Jun , Zhao Yin , Tang Ling‐Long 
Published: July 2024

AbstractDespite docetaxel combined with cisplatin and 5‐fluorouracil (TPF) being the established treatment for advanced nasopharyngeal carcinoma (NPC), there are patients who do not respond positively to this form of therapy. However, the mechanisms underlying this lack of benefit remain unclear. DCAF7 is identified as a chemoresistance gene attenuating the response to TPF therapy in NPC patients. DCAF7 promotes the cisplatin resistance and metastasis of NPC cells in vitro and in vivo. Mechanistically, DCAF7 serves as a scaffold protein that facilitates the interaction between USP10 and G3BP1, leading to the elimination of K48‐linked ubiquitin moieties from Lys76 of G3BP1. This process helps prevent the degradation of G3BP1 via the ubiquitin‒proteasome pathway and promotes the formation of stress granule (SG)‐like structures. Moreover, knockdown of G3BP1 successfully reversed the formation of SG‐like structures and the oncogenic effects of DCAF7. Significantly, NPC patients with increased levels of DCAF7 showed a high risk of metastasis, and elevated DCAF7 levels are linked to an unfavorable prognosis. The study reveals DCAF7 as a crucial gene for cisplatin resistance and offers further understanding of how chemoresistance develops in NPC. The DCAF7‐USP10‐G3BP1 axis contains potential targets and biomarkers for NPC treatment.
High‐Performance Organic–Inorganic Hybrid Conductive Hydrogels for Stretchable Elastic All‐Hydrogel Supercapacitors and Flexible Self‐Powered Integrated Systems
Authors: Cheng Tao , Liu Zhong‐Ting , Qu Jie , Meng Chao‐Fu , He Ling‐Jun , Li Lang , Yang Xuan‐Li , Cao Yu‐Jie , Han Kai , Zhang Yi‐Zhou , Lai Wen‐Yong 
Published: July 2024

AbstractConductive polymer hydrogels exhibit unique electrical, electrochemical, and mechanical properties, making them highly competitive electrode materials for stretchable high‐capacity energy storage devices for cutting‐edge wearable electronics. However, it remains extremely challenging to simultaneously achieve large mechanical stretchability, high electrical conductivity, and excellent electrochemical properties in conductive polymer hydrogels because introducing soft insulating networks for improving stretchability inevitably deteriorates the connectivity of rigid conductive domain and decreases the conductivity and electrochemical activity. This work proposes a distinct confinement self‐assembly and multiple crosslinking strategy to develop a new type of organic–inorganic hybrid conductive hydrogels with biphase interpenetrating cross‐linked networks. The hydrogels simultaneously exhibit high conductivity (2000 S m−1), large stretchability (200%), and high electrochemical activity, outperforming existing conductive hydrogels. The inherent mechanisms for the unparalleled comprehensive performances are thoroughly investigated. Elastic all‐hydrogel supercapacitors are prepared based on the hydrogels, showing high specific capacitance (212.5 mF cm−2), excellent energy density (18.89 µWh cm−2), and large deformability. Moreover, flexible self‐powered luminescent integrated systems are constructed based on the supercapacitors, which can spontaneously shine anytime and anywhere without extra power. This work provides new insights and feasible avenues for developing high‐performance stretchable electrode materials and energy storage devices for wearable electronics.
Selective and Controllable Cracking of Polyethylene Waste by Beta Zeolites with Different Mesoporosity and Crystallinity
Authors: Liu Yanchao , Dai Weijiong , Zheng Jiajun , Du Yanze , Wang Quanhua , Hedin Niklas , Qin Bo , Li Ruifeng 
Published: July 2024

AbstractWaste plastics bring about increasingly serious environmental challenges, which can be partly addressed by their interconversion into valuable compounds. It is hypothesized that the porosity and acidity of a zeolite‐based catalyst will affect the selectivity and effectiveness, enabling a controllable and selective conversion of polyethylene (PE) into gas‐diesel or lubricating base oil. A series of embryonic, partial‐ and well‐crystalline zeolites beta with adjustable porosity and acidity are prepared from mesoporous SBA‐15. The catalysts and catalytic systems are studied with nuclear magnetic resonance (NMR), X‐ray diffraction (XRD), and adsorption kinetics and catalytic reactions. The adjustable porosity and acidity of zeolite‐beta‐based catalysts achieve a controllable selectivity toward gas‐diesel or lubricating base oil for PE cracking. With a catalyst with mesopores and appropriate acid sites, a fast escape and reduced production of cracking of intermediates are observed, leading to a significant fraction (88.7%) of lubricating base oil. With more micropores, a high acid density, and strong acid strength, PE is multiply cracked into low carbon number hydrocarbons. The strong acid center of the zeolite is confirmed to facilitate significantly the activation of hydrogen (H2), and, an in situ ammonia poisoning strategy can significantly inhibit hydrogen transfer and effectively regulate the product distribution.
Caregiver coping mediates the relationship between caregivers’ understanding of dementia as terminal and their distress
Authors: Balasubramanian Ishwarya , Poco Louisa Camille , Andres Ellie Bostwick , Chaudhry Isha , Østbye Truls , Malhotra Chetna ,   PISCES study group
Published: July 2024

AbstractWe assessed which coping strategies (problem‐focused, emotion‐focused, dysfunctional) mediate the association between caregivers’ understanding of dementia as terminal and their distress. A total of 215 caregivers of community‐dwelling persons with severe dementia were surveyed every 4 months over 3 years. A generalized structural equation model was used to test mediation. Caregivers who correctly understood dementia as terminal and those unsure (vs incorrect), experienced more distress (correct: β [95% confidence interval (CI)]: 0.80 [0.00 to 1.60]; unsure: 0.95 [0.04 to 1.87]). Caregivers with correct understanding of dementia as terminal (vs incorrect) employed more dysfunctional (2.01 [0.60 to 3.42]) and problem‐focused coping strategies (2.56 [0.08 to 5.05]). Although dysfunctional and problem‐focused coping (associated with higher distress) mediated the positive association between caregivers’ understanding that dementia is terminal and their distress, emotion‐focused coping (associated with lower distress) did not offset this relationship. Results suggest that terminal illness disclosure to caregivers should be accompanied by interventions to promote emotion‐focused coping strategies.Highlights
Caregivers who understood dementia as terminal experienced more distress.
Dysfunctional and problem‐focused coping mediated the positive relationship between terminal illness understanding and caregiver distress.
Emotion‐focused coping did not offset this relationship.
Development of surface‐treated poly(lactic acid)/zinc oxide biocomposites for 3D printing in bone tissue engineering
Authors: Marega Felippe Migliato , Klok Larissa Aline , Steffen Teresa Tromm , Cunha Daniel A. L. V. , Harb Samarah V. , Kolanthai Elayaraja , Seal Sudipta , Becker Daniela , Pessan Luiz Antonio , Costa Lidiane Cristina 
Published: July 2024

AbstractThe increase in bone fractures has been driving the development of materials for bone repair with better mechanical and biological properties. This work reports the development of poly (lactic acid) (PLA)‐zinc oxide (ZnO) biocomposites for 3D printing of scaffolds to be applied in bone tissue engineering. The ZnO surface was functionalized with maleic anhydride (ZnOMA) by applying radio frequency plasma treatment as an alternative to control the catalytic effects of ZnO on the degradation of the PLA during the molten state processing. PLA and ZnOMA powders were processed using a heated internal mixer and the resulted biocomposites were used to manufacture scaffolds by 3D printing. The scaffolds were characterized by their rheological, thermal, microstructural, mechanical, and biological properties. Compositions containing ZnOMA presented higher viscosities, evidencing the control of degradation by surface functionalization, and achieved an elastic modulus near 1 GPa, suitable for bone applications, unlike the untreated samples. In relation to cell functions, PLA‐ZnOMA scaffolds exhibited cell viabilities at 160%, compared to 50% for untreated samples and stimulated mesenchymal stem cells toward osteoblast. Therefore, ZnO's negative thermal degradation effect on PLA was successfully overcome using plasma functionalization, enabling the 3D printing of bioactive scaffolds with great potential for application in tissue engineering.
Bombyx mori UFL1 facilitates BmNPV proliferation by regulating host cell apoptosis through PERK
Authors: Zheng Yijun , Meng Haonan , Jiang Xiaochun , Huang Shoujun 
Published: July 2024

AbstractUbiquitin‐fold modifier 1 (UFM1) is attached to protein substrates through the sequential activity of an E1 (UBA5)‐E2 (UFC1)‐E3 (UFL1) cascade. UFL1 is the E3 ligase for UFMylation in vertebrates. However, there have been no studies on UFL1 in silkworm to date. In this study, we identified a UFL1 ortholog in Bombyx mori genome. Spatio‐temporal expression profiles showed that BmUFL1 expression was high in the midgut, epidermis, and testis and in the pupa–adult stage. BmUFL1 knockdown inhibited B. mori nucleopolyhedrovirus (BmNPV) proliferation, while BmUFL1 overexpression promoted BmNPV proliferation. Mechanically, protein kinase RNA‐like endoplasmic reticulum kinase (PERK) signaling and cell apoptosis are involved in BmUFL1‐regulated BmNPV proliferation. Overall, these results suggest that BmUFL1 facilitates BmNPV proliferation in silkworm.
Coordination Site Selective Occupation Strategy for Tuning the Photosalient Effects of Photoactive Cd Complexes
Authors: Zhao Shuang , Wang Ning , James Young David , Mi Yan , Hu Fei‐Long 
Published: July 2024

AbstractThe application of photo responsive crystals to useful actuation demands a rational design to elicit controllable movement. The [2+2] photocycloaddition reaction triggers mechanical motion using associated photosalient (PS) effects. We herein report a coordination site selective occupation strategy to modulate the arrangement of C=C bonds and thereby tune the PS effect. Replacing or repositioning the donor atom at one end of the linear ligand allowed for a greater level of molecular structural flexibility, facilitating [2+2] photocycloaddition. The distance between photoreactive centres and coordination sites was adjusted by ligand design to regulate PS behaviour. This work suggests new avenues for modulating PS movement to achieve useful motion.
Pharmacological activation of mesenchymal stem cells increases gene expression pattern of cell adhesion molecules and fusion with neonatal cardiomyocytes
Authors: Khan Irfan , Muneer Rabbia , Qazi Rida‐e‐Maria , Salim Asmat 
Published: July 2024

AbstractCellular therapy is considered a better option for the treatment of degenerative disorders. Different cell types are being used for tissue regeneration. Despite extensive research in this field, several issues remain to be addressed concerning cell transplantation. One of these issues is the survival and homing of administered cells in the injured tissue, which depends on the ability of these cells to adhere. To enhance cell adherence and survival, Rap1 GTPase was activated in mesenchymal stem cells (MSCs) as well as in cardiomyocytes (CMs) by using 8‐pCPT‐2′‐O‐Me‐cAMP, and the effect on gene expression dynamics was determined through quantitative reverse transcriptase‐polymerase chain reaction analysis. Pharmacological activation of MSCs and CMs resulted in the upregulation of connexin‐43 and cell adhesion genes, which increased the cell adhesion ability of MSCs and CMs, and increased the fusion of MSCs with neonatal CMs. Treating stem cells with a pharmacological agent that activates Rap1a before transplantation can enhance their fusion with CMs and increase cellular regeneration.
Transcatheter Fontan completion: Creation of an extracardiac Fontan
Authors: Boudjemline Younes , Hijazi Ziyad M. , Sallehuddin Ahmad , Ghez Olivier 
Published: July 2024

AbstractPatients with functionally univentricular hearts are usually palliated surgically. There have been several reports of successful attempts to complete the Fontan procedure without surgery. The pathways created at the time of the preconditioning were largely reminiscent of the lateral tunnel Fontan. However, this approach is still confidentially limited to a small number of centers. In 2013, we designed a circuit that mimics the actual surgical technique of extracardiac total cavopulmonary connection to allow for transcatheter completion in an animal study. A polytetrafluoroethylene conduit was connected between the pulmonary artery and the inferior vena cava (IVC). The superior anastomosis was occluded to avoid flow between IVC and superior vena cava (SVC). The conduit was connected to the right atrium (RA) and a large fenestration was created to allow free flow from the IVC to the RA. Extrapolating our approach, a center reported the successful transcatheter completion of an extracardiac Fontan in a 6‐year‐old child. However, this technique is not directly transposable to our population of patients who require preconditioning in infancy. We report here an innovative extension of this technique that may allow preparing patients in infancy, ideally at the time of the Glenn in the future, to receive an extracardiac Fontan at 2 years/11 kg without additional surgery.
Well‐Defined Highly‐Coordinated Copper(III) Iodide and Pincer Tris(trifluoromethyl)copper Complexes
Authors: Motornov Vladimir , Ackermann Lutz 
Published: July 2024

AbstractCopper(III) iodide and bromide complexes representing a unique combination of highly‐coordinated metal and soft polarizable anions were synthesized and fully characterized, including X‐ray crystallography. Ligand substitution in well‐defined highly‐coordinated copper complex PyCu(CF3)3 with pincer ligands was achieved to give formally octahedral copper(III) complexes.
Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans
Authors: Gajardo Cortez Abraham I.J. , Lillo‐Moya José , San‐Martín‐Martinez Daniel , Pozo‐Martinez Josue , Morales Pablo , Prieto Juan C. , Aguayo Rubén , Puentes Ángel , Ramos Cristobal , Silva Solange , Catalán Mabel , Ramos Karla , Olea‐Azar Claudio , Rodrigo Ramón 
Published: July 2024

AbstractMyocardial reperfusion injury (MRI) accounts for up to 50% of the final size in acute myocardial infarction and other conditions associated with ischemia‐reperfusion. Currently, there is still no therapy to prevent MRI, but it is well known that oxidative stress has a key role in its mechanism. We previously reduced MRI in rats through a combined antioxidant therapy (CAT) of ascorbic acid, N‐acetylcysteine, and deferoxamine. This study determines the safety and pharmacokinetics of CAT in a Phase I clinical trial. Healthy subjects (n = 18) were randomized 2:1 to CAT or placebo (NaCl 0.9% i.v.). Two different doses/infusion rates of CATs were tested in a single 90‐minute intravenous infusion. Blood samples were collected at specific times for 180 minutes to measure plasma drug concentrations (ascorbic acid, N‐acetylcysteine, and deferoxamine) and oxidative stress biomarkers. Adverse events were registered during infusion and followed for 30 days. Both CAT1 and CAT2 significantly increased the CAT drug concentrations compared to placebo (P < .05). Most of the pharmacokinetic parameters were similar between CAT1 and CAT2. In total, 6 adverse events were reported, all nonserious and observed in CAT1. The ferric‐reducing ability of plasma (an antioxidant biomarker) increased in both CAT groups compared to placebo (P < .001). The CAT is safe in humans and a potential treatment for patients with acute myocardial infarction undergoing reperfusion therapy.
Admittance stability model and equivalent circuit analysis of three‐phase AC systems in different coordinate systems
Authors: Hu Zhe , Han Yang , Zhang Songling , Yang Ping , Zalhaf Amr S. 
Published: July 2024

AbstractIn recent years, with a large number of distributed energy sources connected to the grid, the distribution network has shown a clear trend towards the use of power electronics. As a power conversion interface, the stability of the converter's interaction with the grid has received considerable attention. Adequate admittance (impedance) modeling of the three‐phase grid‐connected converter is a prerequisite for analyzing the stability and resonance characteristics of the grid‐connected system. Understanding the internal mechanisms and proposing effective solutions are crucial to enable power systems to effectively cope with the impact of power electronics. Therefore, by studying the admittance equivalence relationship and equivalent circuit of three‐phase AC systems in various coordinate systems, this paper focuses on solving the non‐uniqueness problem of impedance admittance modeling of three‐phase converter system. It is proposed that the input admittance of the three‐phase asymmetrical system in the dq and fb rotating coordinate systems is a 2‐order matrix and equivalent. The input admittance of the three‐phase unbalanced system in the αβ and “12” static coordinate systems is a 4‐order matrix and equivalent. From both theoretical analysis and simulation verification, it is shown that the number of eigenvalues of the three‐phase asymmetrical system in the stationary coordinate system is twice that in the rotating coordinate system, and the overall damping of the system is improved. The control strategy based on the stationary coordinate system will make the system more stable. The second contribution of this paper is to establish the equivalent circuit of the three‐phase symmetric converter system by the node admittance matrix and extend it to the multi‐machine system to explain the system instability mechanism by the circuit resonance mechanism. Finally, the frequency coupling phenomenon is studied for the three‐phase asymmetrical converter system, and it is explained that it cannot establish an equivalent circuit similar to the three‐phase symmetrical converter system.