bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, characterization, DFT, biological activities and molecular docking analysis of Schiff base ligand and its transition metal complexes
Authors: Todarwal Minakshee Abhijit , Tadavi Samina Karimkha , Sancheti Rakesh Suresh , Bendre Ratnamala Subhash 
Published: June 2024

In this study, we synthesized a tetradentate Salen type Schiff base ligand (H2L = 6,6'-(((4-chloro-1,2-phenylene)bis(azanylylidene))bis(methanylylidene)) bis(2-isopropyl-5-methyl-phenol)) containing N2O2 donor atoms and its analogous transition metal complexes, namely CoL, NiL, CuL, and ZnL. The ligand was prepared through the condensation reaction of 3-isopropyl-6-methylsalicyaldehyde and 4-chloro-1,2-phenylene diamine. Various spectroscopic methods viz. FT-IR, UV-Vis, 1H- and 13C-NMR, ESI-MS, and elemental analysis were utilized to elucidate the synthesized compounds. The free ligand coordinates with the metal ions in 1:1 molar ratio. The bactericidal investigations of the compounds were performed against S. aureus, S. pyogenes, E. coli, and P. aeruginosa. Antimalarial, anti-inflammatory and antioxidant activities were also studied. The DFT study was performed to optimize the geometry and evaluate the chemical reactivity parameters. The molecular docking investigation was performed to evaluate the binding interactions and binding energy of the synthesized compounds against cysteine protease SpeB and lactate dehydrogenase receptor proteins. This investigation established a good correlation between theoretical and practical outcomes.
Crystal structure of 6-amino-3-methyl-4-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
Authors: Sharma Naresh , Karmakar Indrajit , Brahmachari Goutam , Gupta Vivek Kumar 
Published: June 2024

The crystal structure of the title compound, 6-amino-3-methyl-4-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile, were determined by single crystal X-ray structure analysis. The compound C14H12N4O crystallizes in the triclinic crystal system with the P-1 space group (no. 2), having unit cell parameters a = 6.4788(7) Å, b = 8.8433(7) Å, c = 10.7377(9) Å, α = 103.456(7)°, β = 99.207(8)°, γ = 92.451(8)°, V = 588.55(9) Å3, Z = 2. The crystal structure was solved by direct methods using single-crystal X-ray diffraction data collected at room temperature and refined by full-matrix least-squares procedure with a final R-value of 0.0464 for 1432 observed reflections. The dihedral angle between the pyran ring and the pyrazole ring is 178.08(6)°, between the pyrazole ring and the benzene ring is 98.92(6)° and between the pyran ring and the benzene ring is 97.10(5)°. The molecules in the crystal are linked to an infinite two-dimensional network by N−H···N and C−H···π types of hydrogen bonds. Molecules are also reinforced by the π···π interaction between the pyrazole ring and the pyran ring, respectively.
Studying and Learning Islam in Achieving Amal during Ramadan in the Community of Dusun Suka Makmur, Riau
Authors: Iwanda Lubis Muya Syaroh , Aldila Fadhlika  , Siregar Khadijah Nadhirah , Miftahul Jannah  , Nur Azlin Karimah  , Sinta Aqila Istikomah  , S Suci Meilani 
Published: June 2024

The prosperous villagers were in the new village of rambah, kec. Rambah samo, kab. Tip upstream, prov. Riau is a society that has a strong desire to seek knowledge. The reasons for this desire are based on a society that has also begun to understand the Koran, the doctrine of Islam. Unfortunately, people's desires cannot be well expressed because there are some factors that cause them to be irresoluble and running. The lack of manpower and a da 'i in the village is one reason, not to mention a female daiyah or teacher. It is also felt by the taqwa mosque -- the people at the taqwa mosque -- have lost the will to learn because there is neither thrusters nor teachers. For women, there are no da 'iyah women salhaj salaf places to consult on the problems of women, to make women in these villages feel troubled, while women and children are desperately in need, their need for daiyah is so well described by the still many instances of misreading the Koran, still mistaking in worship (especially those that are included in the harmony of Islam), And the lack of understanding of women to the laws that pertain to women. The methods of this study use community based research (CBR), the findings of scientific research activities conducted have encouraged and given children and mothers the opportunity to be active and involved in increasing their love of the quran, Arabic and islamic language more deeply into women's fiqh laws during Ramadan.
Automatic adjoint-based inversion schemes for geodynamics: reconstructing the evolution of Earth's mantle in space and time
Authors: Ghelichkhan Sia , Gibson Angus , Davies D. Rhodri , Kramer Stephan C. , Ham David A. 
Published: July 2024

Abstract. Reconstructing the thermo-chemical evolution of Earth's mantle and its diverse surface manifestations is a widely recognised grand challenge for the geosciences. It requires the creation of a digital twin: a digital representation of Earth's mantle across space and time that is compatible with available observational constraints on the mantle's structure, dynamics and evolution. This has led geodynamicists to explore adjoint-based approaches that reformulate mantle convection modelling as an inverse problem, in which unknown model parameters can be optimised to fit available observational data. Whilst there has been a notable increase in the use of adjoint-based methods in geodynamics, the theoretical and practical challenges of deriving, implementing and validating adjoint systems for large-scale, non-linear, time-dependent problems, such as global mantle flow, has hindered their broader use. Here, we present the Geoscientific ADjoint Optimisation PlaTform (G-ADOPT), an advanced computational modelling framework that overcomes these challenges for coupled, non-linear, time-dependent systems by integrating three main components: (i) Firedrake, an automated system for the solution of partial differential equations using the finite-element method; (ii) Dolfin-Adjoint, which automatically generates discrete adjoint models in a form compatible with Firedrake; and (iii) the Rapid Optimisation Library, ROL, an efficient large-scale optimisation toolkit; G-ADOPT enables the application of adjoint methods across geophysical continua, showcased herein for geodynamics. Through two sets of synthetic experiments, we demonstrate the application of this framework to the initial condition problem of mantle convection, in both square and annular geometries, for both isoviscous and non-linear rheologies. We confirm the validity of the gradient computations underpinning the adjoint approach, for all cases, through second-order Taylor remainder convergence tests and subsequently demonstrate excellent recovery of the unknown initial conditions. Moreover, we show that the framework achieves theoretical computational efficiency. Taken together, this confirms the suitability of G-ADOPT for reconstructing the evolution of Earth's mantle in space and time. The framework overcomes the significant theoretical and practical challenges of generating adjoint models and will allow the community to move from idealised forward models to data-driven simulations that rigorously account for observational constraints and their uncertainties using an inverse approach.
Evaluating Murābahah Contract Practices in BPRS Financing Agreement No. 8854/MBA/11/2010 and Associated Challenges in Islamic Banking
Authors: Wijaya Adi , Fajriyati Latifah Adi 
Published: June 2024

This research aims to analyze the application of the murābahah contract in BPRS financing agreement number 8854/MBA/11/2010 related to the payment period and problems that may arise in BPRS financing practices in Islamic banking. The research method uses a literature study that uses an empirical normative approach, which focuses on the application of normative law to certain legal situations that occur in society. the results showed that the application of the murābahah contract in the BPRS financing agreement Number 8854 / MBA / 11/2010 in the context of the payment period. In the application of the murābahah financing contract, the profit is not more than one-third or one-fifth and the repayment period is not more than three years because if it is more, it will cause ribā because the calculation uses a profit calculation instead of profit sharing as based on the calculation. second Problems that can occur in murābahah financing. In the practice of murābahah financing, there are various problems that can occur, including non-transparent margins, risks of ownership and storage, problems with the quality of goods, risk of bad financing, uncertainty of market prices, high involvement of third parties and the difficulty of renegotiating and if viewed from various aspects such as sharia aspects, legal aspects, and operational aspects, it is very likely that there will be a failure in the contract.
EDUKASI DALAM RAYA UPAYA PENURUNAN STIGMA TERHADAP PENDERITA HIV/AIDS DI DESA AMBENGAN
Authors: Luh Yenny Armayanti  , Pratama Agus Ari , Karlina Sumiari Tangkas  
Published: June 2024

Stigma masyarakat terhadap penderita HIV/AIDS sampai saat ini berpengaruh besar terhadap kualitas hidup penderita HIV yang berdampak juga terhadap akses ke pelayanan kesehatan dan keteraturan minum obat. Pengetahuan yang kurang mengenai HIV/AIDS dapat menyebabkan seseorang memberikan stigma negative kepada penderita HIV/AIDS. Tujuan dari pengabdian ini adalah untuk dapat memberikan edukasi tentang HIV/AID yang diharapkan dapat menurunkan stigma. Jumlah sasaran mitra yaitu 35 orang masyarakat perempuan dan laki-laki. Kegiatan ini dievaluasi menggunakan kuesioner yang meliputi identitas dan pertanyaan seputar pengetahuan dan stigma. Bahan yang disiapkan adalah LCD, proyektor, materi yang disampaikan secara bergantian oleh dosen pelakasana. Metode yang dilaksanakan dimulai dengan tahap persiapan, pelaksanaan dan evaluasi kegiatan. Hasil pengabdian ini tampak bahwa terdapat perbedaan rata-rata pengetahuan dan stigma sebelum diberikan edukasi dan sesudah diberikan edukasi dinilai dari pengetahuan sebelum dengan rata-rata 60,21 dan pengetahuan sesudah diberikan edukasi meningkat menjadi 80,46. Sedangkan rerata skor stigma juga mengalami peningkatan dari 56,72 menjadi 82,31. Simpulannya bahwa edukasi efektif dilakukan sebagai upaya untuk menurunkan stigma negative terhadap penderita HIV/AIDS
EDUKASI PMT (PEMBERIAN MAKANAN TAMBAHAN) BERBAHAN PANGAN LOKAL DUSUN TINGA, DESA SEKARDADI, KINTAMANI
Authors: Meriyani Dewi Aprelia , Putri Putu Sukma Mega 
Published: June 2024

Stunting merupakan kondisi dimana fisik dan perkembangan anak terhambat dari biasanya, hal ini bisa terjadi di 1000 pertama hari kehidupan. Stunting dapat terjadi karena kurangnya asupan nutrisi saat kehamilan sampai anak umur 5 tahun. Asupan nutrisi yang terpenting saat 1000 HPK adalah terpenuhinya unsur utama yaitu protein, energi dan zat gizi lainnya yang di perlukan untuk pertumbuhan yang optimal. Pemerintah mengelurkan Peraturan Presiden Nomor 72 Tahun 2021 tentang Percepatan Penurunan Stunting yang holistik, integratif, dan berkualitas melalui koordinasi, sinergi, dan sinkronisasi di antara pemangku kepentingan. Di Kabupaten Bangli saat ini sedang melaksanakan pemberian PMT berbahan pangan lokal yang merupakan salah satu strategi untuk pencegahan stunting. Di Dusun Tinga, cara pengolahan PMT berbahan pangan lokal merupakan masalah yang sangat krusila dalam memenuhi gizi pada balita. Tujuan dari pengambidan ini adalah meningkatkan pengetahuan ibu tentang cara pengolan dan pemberian PMT berbahan pangan lokal. Hasil pengabdian masyarakat menunjukan bahwa pemberian penyuluhan tentang cara pengolahan PMT berbahan pangan lokal memberikan dampak yang sangat signifikan pada peningkatan pengetahuan ibu balita.
Identifikasi Tujuan Tata Kelola Teknologi Informasi PLT FST UIN Jakarta Menggunakan Framework COBIT 2019
Authors: Aeni Hidayah Nur , Nurbojatmiko  , Ade Arfani Mizan , Yuliwanda Anggi Kusumaatuti  
Published: June 2024

Information technology (IT) has an important role in increasing efficiency and providing benefits to decision making in various sectors. IT governance is important for organizational sustainability and performance. This research focuses on the Integrated Laboratory Center (PLT) FST UIN Jakarta which still depends on external parties for IT governance, creating potential risks and uncertainty in its operations. Therefore, this research aims to analyze the implementation of COBIT 2019 as a guide in identifying IT governance objectives that suit the needs of PLT FST UIN Jakarta. The research method used in this research involves the COBIT 2019 theoretical approach, with a focus on the goal cascade concept. This approach enables a systematic translation process of stakeholders' needs for IT systems into more specific goals and appropriate strategic steps. The results show eight COBIT 2019 domains that are relevant to IT governance objectives in PLT, which include APO02 (Managed strategy), APO08 (Managed relationships), APO10 (Managed vendors), APO11 (Managed quality), BAI04 (Managed availability and capacity), DSS01 (Managed operations), DSS03 (Managed problems(, and MEA02 (Managed system of internal control) The recommendations resulting from this research are designed to improve the performance and maturity of IT processes at PLT FST UIN Jakarta in accordance with the IT governance objectives that have been identified. This is expected to provide a stronger foundation for managing and optimizing the use of IT to support operations and achieve organizational goals more effectively.
Pengaruh Kenaikan Pajak Pertambahan Nilai Dan Digital Marketing Terhadap Keputusan Pembelian Di Generasi Z Dalam Transaksi E-Commerce Sebagai Pemoderasi
Authors: Julito Kiko Armenita , Ramadani Istifa 
Published: June 2024

Penelitian ini dilatar belakangi karena adanya kenaikan PPN yang semula 10% menjadi 11%. Penelitian ini bertujuan untuk melihat pengaruh kenaikan pajak dan digital marketing terhadap keputusan pembelian yang dimoderasi oleh transaksi e-commerce. Adanya transaksi e-commerce dapat memperkuat hubungan antara kenaikan PPN, digital marketing, terhadap keputusan pembelian. Penelitian ini menggunakan metode analisis Structural Equation Modelling. Pengolahan data pada penelitian ini menggunakan software SmartPLS (Partial Least Square). Hasil penelitian ini ialah menghasilkan jawaban dari perumusan yang telah dibuat yaitu yang pertama, menunjukkan bahwa kenaikan ppn berpengaruh signifikan terhadap keputusan pembelian, yang artinya berdasarkan hasil tersebut hipotesis dalam penelitian ini diterima. Kedua, digital marketing tidak berpengaruh signifikan terhadap keputusan pembelian, yang artinya berdasarkan hasil tersebut hipotesis dalam penelitian ini ditolak. Ketiga, transaksi e-commerce berpengaruh signifikan terhadap keputusan pembelian, yang artinya berdasarkan hasil tersebut hipotesis dalam penelitian ini diterima. Keempat, transaksi e-commerce memperkuat hubungan antara kenaikan PPN terhadap keputusan pembelian transaksi e-commerce memperkuat hubungan antara kenaikan PPN terhadap keputusan pembelian berpengaruh signifikan, yang artinya berdasarkan hasil tersebut hipotesis dalam penelitian ini diterima. Kelima, transaksi e-commerce memperkuat hubungan antara digital marketing terhadap keputusan pembelian tidak berpengaruh signifikan, yang artinya berdasarkan hasil tersebut hipotesis dalam penelitian ini ditolak. Dengan adanya penelitian ini, diharapkan masyarakat selaku konsumen akhir dapat mengetahui tentang kenaikan ppn yang dimana kenaikan tersebut berimbas pada transaksi di e-commerce karena masyarakat tertarik membeli produk yang dipromosikan melalui digital marketing sehingga masyarakat dapat membuat keputusan pembelian yang digunakan untuk memenuhi kebutuhan sehari-hari
PENGARUH KOMBINASI TERAPI RELAKSASI AUTOGENIK DAN TERAPI MUSIK KLASIK UNTUK MENURUNKAN INTENSITAS NYERI PADA PASIEN UNSTABLE ANGINA PECTORIS (UAP)
Authors: Maghfirawati Okti , Martawinarti Rts Netisa , Erwinsyah Erwinsyah 
Published: June 2024

Latar Belakang: Angina Pectoris adalah suatu sindroma klinik yang disebabkan oleh ketidakseimbangan antara kebutuhan (Demand) dan suplai aliran Arteri Coroner yang biasanya ditandai dengan nyeri dada yang menjalar ke leher, rahang, bahu kiri, sampai dengan jari-jari, punggung atau pundak kiri. Nyeri adalah keluhan utama pada pasien unstable angina pectoris. Upaya non farmakologis yang dapat mengatasi nyeri pada pasien UAP adalah kombinasi relaksasi autogenik dan terapi musik klasik. Tujuan: Penelitian ini dilakukan untuk mengetahui pengaruh kombinasi relaksasi autogenik dan terapi musik klasik terhadap intensitas nyeri pada pasien unstable angina pectoris. Metode: Menggunakan desain laporan kasus (case report). Subjek yang digunakan pasien UAP yang mengalami nyeri akut dengan total subjek 2 pasien, 1 intervensi dan 1 kontrol. Intrumen yang digunakan adalah NRS (Numeric Rating Scale). Penelitian dilakukan selama 3 hari perawatan, 2 kali sehari selama 15-30 menit. Hasil: Pada hari ke-3 pemberian intervensi pada pasien intervensi terjadi penurunan skala nyeri dari skala nyeri 6 menjadi tidak nyeri. Sedangkan pada pasien kontrol, terjadi penurunan skala nyeri dari skala 6 menjadi 2. Hasil menunjukan bahwa nyeri yang dialami pasien intervensi dapat berkurang setelah dilakukan relaksasi autogenik dan terapi musik klasik sampai hari terakhir. Kesimpulan: Pengaplikasian relaksasi autogenik dan terapi musik klasik menunjukan adanya perubahan dan memperoleh hasil yang optimal dan terdokumentasi dengan baik. Terapi ini baik dilakukan pada pasien UAP Kata Kunci : Terapi musik klasik, Relaksasi autogenik, Unstable Angina Pectoris, Nyeri akut
An Approach for Efficient and Accurate Phishing Website Prediction Using Improved ML Classifier Performance for Feature Selection
Authors: Awasthi Anjaneya , Goel Noopur 
Published: June 2024

The article discusses the use of machine learning (ML) to combat phishing websites, which are deceptive sites that mimic trusted entities to steal sensitive information. This is why the continued invention of methods of identifying and counteracting phishing threats is beneficial. Such attacks pose significant risks to the integrity of online security. To enhance the success rate and specificity of predicting phishing websites, this study proposes a new approach that utilizes machine learning algorithms. To enhance the methods mentioned above and achieve better results in classification and better prediction of customer behaviour, the main points exposed to further transformations are increasing classifier accuracy and selecting an optimal feature space. Traditional anti-phishing strategies like blacklisting and heuristic searches often have slow detection times and high false positive rates. The article introduces a novel feature selection method to extract highly correlated features from datasets, thereby enhancing classifier accuracy. Using six feature selection techniques on a phishing dataset, it evaluates eight classifiers, including SVM, Logistic Regression, Random Forest, and others. The study finds that the Random Forest classifier combined with the Chi-2 feature selection method significantly improves model accuracy, achieving up to 96.99%.
Systemic Regulatory Abnormalities in Glycemic Control and its Relation with Depression - A Cross-Sectional Study
Authors: M Aravindh , Kailash Shabeeba Z , Sureshkumar Kailash 
Published: June 2024

Globally, depression is the 3rd leading cause of disability-adjusted life years. The presence of depression and its symptoms has been associated with improper control of glucose and poor glycemic index and a bidirectional relationship was seen between depressive disorders and diabetes mellitus. Depression, even at subclinical levels, has the tendency to increase the risk of incident type 2 diabetes by 25–60%. This study aims to find the prevalence of Type 2 diabetes mellitus(T2DM) in depression patients and to find the relationship between the severity of depression and the severity of T2DM in a Cross-sectional study. A total of 178 patients who attended psychiatry OPD of a tertiary healthcare hospital for a study period of 6 months were recruited into the study after considering inclusion and exclusion criteria evaluated by an experienced psychiatrist. Details like sociodemographic profiles and clinical data related to Major depression and T2DM were collected through self-structured proforma. To assess the severity of depression, HAM-D scale was used and the glycemic severity measure was used to assess the severity of T2DM by a well-trained psychiatrist. Statistical analysis was done and results were framed. The prevalence of Type 2 Diabetes mellitus in depressive disorder patients was found to be 25.2%. A significant association was seen between the severity of T2DM and the severity of depression, with a p-value of 0.013 and a chi-square value of 12.699. Significance with certain clinical factors like insulin usage (F=5.635; p = 0.019) and drug compliance (F=16.841; p <0.001) was seen in T2DM patients with depression. Nearly ¼th of the patients with depression had T2DM and the severity of hyperglycaemia was also found to be high as those patients were on insulin administration, other medical comorbidity disorders were present and drug compliance was found to be poor. Triglyceride glucose index was also found to be high in patients with severe depression, which contributes to improper blood glucose balance. Treating and reducing both the severity of T2DM and depression simultaneously is needed to improve the functioning of the patients and improve the retention in treatment and drug compliance, thereby preventing morbidity and mortality.
Effectiveness of an Information Booklet on the Awareness of Antimicrobial Resistance (AMR) among Health Care Professionals in a Selected Primary Care Hospital
Authors: Palayan Sasikala , Mariappan Karthika Devi , Ramanathan Kavitha , Subramanian Shenbaga Sundaram , Alhalaiqa Fadwa , Alahmadi Ghadeer Ghazi , Qawagzeh Subhi Mustafa 
Published: June 2024

The study aimed to assess the level of knowledge on Antibiotics and its resistance among healthcare professionals and the effectiveness of an information booklet, which includes the Centers for Disease Control and Prevention (CDC) guidelines for to use of Antibiotics to prevent Antimicrobial resistance (AMR). AMR occurs when bacteria change over time and no longer respond to medicines. Antimicrobial resistance leads to higher medical costs, prolonged hospital stays and increased mortality. Knowledge of Antibiotics is essential in preventing from ill effects of AMR. According to the CDC, in 2018, inappropriate prescribing of antibiotics contributed to antibiotics-resistant conditions, which led to 2 million infections and killed about 23,000 Americans annually. In India, 4.95 million people died in 2019 suffered from drug-resistant infections and antibiotic resistance was the direct cause for 1.27 million of those deaths. An experimental research design employed non probability convenient sampling technique to select the 60 samples in a selected primary care hospital. The majority, 44 (73%), of health professionals were between the ages of 21 and 30 years, 40(67%) were nurses, 13(22%) were medical practitioners and 7(11%) were pharmacists. While considering their area of work majority 20(33%) of them, were from the ward and 14(23%) from the ICU setting. Level of knowledge gain score measured using Extended McNemar`s chi-square test revealed health professionals gained 20.27% with 95% CI and it was found statically significant (c2=43.81 P=0.001***). The study results recommend such an interdisciplinary approach of training doctors, nurses and pharmacists to become sensitive and update themselves to reduce the incidence of Antimicrobial resistance among the common public.