bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-transplant crossmatch-negative donor-specific anti-HLA antibody predicts acute antibody-mediated rejection but not long-term outcomes in kidney transplantation: an analysis of the Korean Organ Transplantation Registry
Authors: Lee Haeun , Lee Hanbi , Sun In O , Park Jung Hwan , Park Jong-Won , Ban Tae Hyun , Yang Jaeseok , Kim Myoung Soo , Yang Chul Woo , Chung Byung Ha ,   Korean Organ Transplantation Registry Study Group
Published: July 2024

BackgroundPre-transplant donor-specific anti-human leukocyte antigen antibody (HLA-DSA) is a recognized risk factor for acute antibody-mediated rejection (ABMR) and allograft failure. However, the clinical relevance of pre-transplant crossmatch (XM)-negative HLA-DSA remains unclear.MethodsWe investigated the effect of XM-negative HLA-DSA on post-transplant clinical outcomes using data from the Korean Organ Transplantation Registry (KOTRY). This study included 2019 living donor kidney transplant recipients from 40 transplant centers in South Korea: 237 with HLA-DSA and 1782 without HLA-DSA.ResultsABMR developed more frequently in patients with HLA-DSA than in those without (5.5% vs. 1.5%, p&lt;0.0001). Multivariable analysis identified HLA-DSA as a significant risk factor for ABMR (odds ratio = 3.912, 95% confidence interval = 1.831–8.360; p&lt;0.0001). Furthermore, the presence of multiple HLA-DSAs, carrying both class I and II HLA-DSAs, or having strong HLA-DSA were associated with an increased incidence of ABMR. However, HLA-DSA did not affect long-term clinical outcomes, such as allograft function and allograft survival, patient survival, and infection-free survival.ConclusionPre-transplant XM-negative HLA-DSA increased the risk of ABMR but did not affect long-term allograft outcomes. HLA-incompatible kidney transplantation in the context of XM-negative HLA-DSA appears to be feasible with careful monitoring and ensuring appropriate management of any occurrence of ABMR. Furthermore, considering the characteristics of pre-transplant XM-negative HLA-DSA, the development of a more detailed and standardized desensitization protocol is warranted.
Associations of micronutrients and lipids with prediabetes and glycemic parameters in adolescent girls of the rural DERVAN cohort (DERVAN-9)
Authors: Patil Suvarna , Dervankar Omkar , Hardikar-Bhat Pallavi , Joglekar Charudatta , Bhat Rohit , Patil Netaji , Yadav Arvind 
Published: July 2024

BackgroundWe investigated the associations of micronutrients and lipids with prediabetes, glycemic parameters, and glycemic indices among the adolescent girls of the DERVAN (aDolescent and prEconception health peRspectiVe of Adult Non-communicable diseases) cohort study from rural India.MethodsWe recruited 1,520 adolescent girls aged 16–18 years. We measured glycemic parameters (glucose, insulin and HbA1C), lipids (total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL], and triglycerides), and micronutrients (vitamin B12, folate, and vitamin D). Prediabetes was defined using American Diabetes Association criteria (fasting glucose ≥100 mg/dL or HbA1C ≥5.7%). Glycemic indices (insulin resistance, insulin sensitivity, and β cell function) were calculated using the homeostasis model. Associations of prediabetes, glycemic parameters and glycemic indices with micronutrients and lipids were analyzed by multiple logistic regressions.ResultsThe median age and Body Mass Index (BMI) were 16.6 years and 17.6 kg/m2, respectively. Overall, 58% of girls had a low BMI. Median vitamin B12, folate, and vitamin D concentrations were 249.0 pg/mL, 6.1 ng/mL, and 14.2 ng/mL, respectively. The deficiencies observed were 32.1% for vitamin B12, 11.8% for folate, and 33.0% for vitamin D. Median total cholesterol, LDL, HDL, and triglyceride concentrations were 148.0 mg/dL, 81.5 mg/dL, 50.8 mg/dL, and 61.5 mg/dL, respectively. Elevated total cholesterol, LDL, and triglycerides were observed in 4.8, 4.0, and 3.8%, respectively, while low HDL was observed in 12.8%. Prediabetes was observed in 39.7% of the girls. Among lipids, total cholesterol and LDL were higher in girls with prediabetes (p &lt; 0.01 for both). In a multivariate model containing cholesterol and vitamin B12/folate/vitamin D, prediabetes was associated with high cholesterol. Prediabetes was also associated with high LDL, independent of folate and vitamin D. Poor insulin secretion was high in those with low vitamin B12. Elevated insulin resistance was associated with low HDL. The likelihood of high insulin sensitivity was reduced in those with high triglycerides. The likelihood of poor β cell function was high in those with high LDL. Statistical interactions between micronutrients and lipids for prediabetes and glycemic outcomes were not significant.ConclusionThere was a substantial deficiency of micronutrients and an absence of dyslipidemia. Our results indicate the need for lipid and micronutrient-based interventions in adolescence to improve glycemic outcomes. Maintaining adequate storage of not only micronutrients but also lipids in adolescent girls is likely to reduce diabetes risk in adulthood.
Global research trends on gut microbiota and metabolic dysfunction-associated steatohepatitis: Insights from bibliometric and scientometric analysis
Authors: Alam Naqash , Jia Linying , Cheng Ao , Ren Honghao , Fu Yu , Ding Xinhua , Haq Ihtisham Ul , Liu Enqi 
Published: July 2024

BackgroundMetabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory subtype of metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been proposed as a replacement term for NAFLD, a common, multifactorial and poorly understood liver disease whose incidence is increasing worldwide. In recent years, there has been increasing scientific interest in exploring the relationship between gut microbiota and MASH. To learn more about the gut microbiota in MASH, this study aims to provide a comprehensive analysis of the knowledge structure and research hotspots from a bibliometric perspective.MethodsWe searched the Web of Science Core Collection for articles and reviews that covered the connections between gut microbiota and MASH over the last decade. The Online Analysis Platforms, VOSviewer, CiteSpace, the R tool “bibliometrix” were used to analyzed existing publications trends and hotspots.ResultsA total of 4,069 documents related to the interaction between gut microbiota and MASH were retrieved from 2014 to 2023. The number of annual publications increased significantly over the last decade, particularly in the United States and China. The University of California-San Diego was the most productive institution, while researcher Rohit Loomba published the most papers in the field. Younossi ZM was ranked as the first co-cited author and largest contributor of highly cited articles in the field. Gastroenterology and hepatology were the most common specialty category. The most cited journal in the last decade was Hepatology. The Keyword Bursts analysis highlighted the importance of studying the association between gut microbiota and MASH, as well as related factors such as metabolic syndrome, insulin resistance, endotoxemia and overgrowth of gut bacteria. Keyword clusters with co-citation were used to illustrate important topics including intestinal permeability, insulin sensitivity and liver immunology. The most common keywords include insulin resistance, obesity, dysbiosis, inflammation and oxidative stress, which are current hotspots.ConclusionOur analysis highlights key aspects of this field and emphasizes multiorgan crosstalk in MASLD/MASH pathogenesis. In particular, the central role of the gut-liver axis and the significant influence of gut microbiota dysbiosis on disease progression are highlighted. Furthermore, our results highlight the transformative potential of microbiota-specific therapies and cover the way for innovative healthcare and pharmaceutical strategies.
Perceived access to social support during and after TB treatment in Mbeya and Songwe regions, Tanzania: perspectives from TB patients and survivors set against health care providers
Authors: Kilima Stella P. , Mubyazi Godfrey M. , Moolla Aneesa , Ntinginya Nyanda E. , Sabi Issa , Mwanyonga Simeon P. , Evans Denise 
Published: July 2024

IntroductionPulmonary tuberculosis (PTB) remains a life-threatening disease in Tanzania, with negative physical, financial, economic and psychosocial consequences to individuals and the society. It mainly lowers the quality of life of patients, survivors and their families, especially those in the poorest and socially deprived categories.ObjectivesTo report and discuss a qualitative study that assessed the nature of social support desired and received by PTB patients and survivors. Participants were given a chance to share their experiences and their perceptions on whether the social support they desired had an impact on their treatment-seeking behaviour and treatment adherence.MethodsFace-to-face interviews were conducted with the three aforementioned groups, purposively selected at a TB clinic between October 2020 and March 2021. The questions covered topics related to the types of social support desired and the sources of support during and after treatment, if any. Interviews were concluded until no new information was obtained. Data analysis was facilitated using NVivo 12 software.ResultsParticipants pointed out a need for psychosocial, financial, and material support during and after treatment. However, they sometimes miss support from family/household members or the rest of the community. Because of this experience, they lived with difficulties, facing hardships when required to pay out of pocket for transport during the care-seeking. Survivors testified experience of a denial of support by even their close relatives who regarded them as no longer needing it after recovering. Patients and survivors also reported experience of social isolation as they were believed able to transmit PTB infections. Limited psychological support at the contacted TB clinics was another experience reported. TB clinic staff's experiences confirmed almost all the experiences shared by their clients. With limited support, resilience and self-care were identified as key mechanisms for coping.ConclusionComplete recovery from PTB is possible, but reverting to a normal life is difficult without social support. Policies and programs need to increase opportunities for social support for TB patients and survivors. Doing so is likely to improve TB-related treatment, care-seeking practices, and adherence.
Efficacy of a telehealth cognitive behavioral therapy for improving sleep and nightmares in children aged 6–17
Authors: Cromer Lisa DeMarni , Bell Sarah Beth , Prince Lauren E. , Hollman Nicholas , El Sabbagh Elissar , Buck Tara R. 
Published: July 2024

IntroductionThis study examined the efficacy of a five-module cognitive behavioral therapy for nightmares in children (CBT-NC) and improving sleep.Materials and methodsForty-six youth aged 6–17 years with sleep problems and at least weekly chronic and distressing nightmares were randomized to treatment (n = 23) or waiting list (n = 23) using a block four randomized design. Among participants, 65% (n = 30) were White, 4% (n = 2) were Black/African American, 2% (n = 1) were Asian American, 13% (n = 6) were Native American or Pacific Islander, and 15% (n = 7) were multiracial. Fifty percent of participants (n = 23) were cisgender girls, 35% were cisgender boys (n = 16), 7% were transgender boys (n = 3), and 9% were gender non-binary (n = 4). The baseline nightmare persistence ranged from 6 months to 13.5 years. The treatment adapted exposure, relaxation, and rescription therapy for trauma-related nightmares in adults and added elements of cognitive behavioral therapy for insomnia in children. Psychoeducation included topics of sleep and nightmares, relaxation, anxiety management, and sleep hygiene; the youth were guided through nightmare exposure and rescription.ResultsThere was a statistically significant improvement in the number of nights with awakening (Cohen's d = 1.08), the number of weekly nightmares (Cohen's d = 0.82), and nightmare distress (Cohen's d = 1.05) for the treatment group compared to the wait-list group. Parent-reported youth sleep improved for the entire group from pretreatment to posttreatment (p &lt; 0.001) but did not reach statistical significance for between-subjects analyses of the treatment group compared to the wait-list group (p = 0.05). Between-subjects analyses saw improvement for the treatment group compared to the wait-list group on internalizing and externalizing problems and suicidal thoughts and behaviors.DiscussionThis study supports the efficacy of CBT-NC for improving sleep maintenance, nightmare frequency and distress, and other mental health difficulties in youth. Preliminary evidence of possibly improving suicidal thinking and behavior is also presented.Clinical trial registrationhttps://clinicaltrials.gov/study/NCT05588739, identifier: NCT05588739.
Establishment of a Protocol for Viability qPCR in Dental Hard Tissues
Authors: Sterzenbach Torsten , Neumann Vanessa , Trips Evelyn , Basche Sabine , Hannig Christian , Kühne Marie-Theres 
Published: July 2024

The aim of the study was to establish a live/dead qPCR with propidium monoazide (PMA) that can quantitatively differentiate between viable/non-viable microorganisms in dental hard tissues. Human premolars (n = 88) were prepared with nickel–titanium instruments and incubated with E. faecalis (21 d). Subsequently, the bacteria in half of the teeth were devitalized by heat inactivation (100 °C, 2 h). The following parameters were tested: PMA concentrations at 0 µmol (control), 50 µmol, 100 µmol, and 200 µmol; PMA incubation times of 30 min and 60 min, and blue light treatment for 30 min and 60 min. The teeth were ground using a cryomill and the bacterial DNA was quantified using qPCR, ANOVA, and p = 0.05. The qPCR of the control group detected a similar number of avital 9.94 × 106 and vital 1.61 × 107 bacterial cells. The use of PMA inhibited the amplification of DNA from non-viable cells during qPCR. As a result, the best detection of avital bacteria was achieved with the following PMA parameters: (concentration, incubation time, blue light treatment) 200-30-30; 5.53 × 104 (avital) and 1.21 × 100.7 (vital). The live/dead qPCR method using PMA treatment is suitable for the differentiation and quantification of viable/non-viable microorganisms in dentin, as well as to evaluate the effectiveness of different preparation procedures and antimicrobial irrigants in other biological hard substances.
Karl Millöcker - Notizen zu Leben und Werk eines Unterschätzten
Authors: Glanz Christian 
Published: July 2024

Né à Vienne en 1842, Karl Millöcker fit ses études au conservatoire de cette ville (flûte, solfège), puis il fit partie de l’orchestre du Theater in der Josefstadt (1858-1864). Plus tard, à Graz, il fut pendant deux ans deuxième chef d’orchestre du Thalia Theater. C’est là qu’il composa sa première opérette et plusieurs musiques de scène pour des pièces populaires. Après une brève activité à Pest, Millöcker revint en 1866 à Vienne et, en 1869, il fut engagé au Theater an der Wien où, après 1882, il créa et dirigea ses propres opérettes. Grâce au succès de Der Bettelstudent (L’Etudiant pauvre), Millöcker put mener une existence de compositeur indépendant. Cardiaque depuis 1896, il mourut à Baden en 1899.
Millöcker est un compositeur sous-estimé. Comparé à Suppé et à Strauß, on ne lui reconnaît qu’un talent mineur. Mais dans la réception de l’opérette viennoise, on souligne que son oeuvre se caractérise par ses ressemblances, au plan esthétique, avec l’opéra. Millöcker excelle surtout dans le comique et la parodie, ce qui rapproche sa production de l’opérette étrangère, telle celle d’Offenbach ou de Sullivan, mais ses oeuvres contiennent aussi divers éléments de l’opérette classique. Quant à l’orchestre, Millöcker sait l’utiliser de façon très diversifiée ; il privilégie aussi les effets dramatiques reposant entre autres sur des scènes dansées.
“In italiano è meglio”. Gregor von Rezzoris italienische Sendung
Authors: Landolfi Andrea 
Published: July 2024

Die Darstellung Italiens in den Werken von Gregor von Rezzori ist Teil und Entwicklung einer langen literarischen Tradition, die bei Goethe, Platen, Hofmannsthal und Thomas Mann ihre Höhepunkte erreicht. Mit Gregor von Rezzori nimmt aber die Darstellung Italiens die Merkmale einer Klage auf sich. Diese Klage betrifft nicht nur Venedig oder Italien, sondern die gesamte abendländische Weltanschauung, und realisiert sich in der Form der Parodie.
Das Italienbild der ersten Werke Rezzoris ist romantisch, fast exotisch und ganz unrealistisch. Es folgt, etwa in den siebziger Jahren, ein journalistisch skandalsüchtiges Bild, ein „deutsches“ Italien, in dem alle Gemeinplätze bewußt karikiert werden. Doch, die Liebe zum Land ist hier schon sehr klar spürbar. Erst im Büchlein Italien (1996) wird die Wende sichtbar. Die Liebe zum Land wird deutlicher ausgedrückt und ein echteres Bild Italiens kommt aus den Schriften dieser Zeit heraus, auf jedem Fall ein „italienischeres“, obwohl das ganze immer noch zwischen Gemeinplatz und journalistischer „Pseudo-Wahrheit“ schwebt.
Diese Liebe findet besonders in dem Verhältnis zur italienischen Sprache Ausdruck. Italienisch war für Gregor von Rezzori die Sprache der Liebe und der Freundschaft, des täglichen Lebens, insbesondere die Sprache einer lichten und gleichzeitig tiefen Lebensweisheit. Obwohl es nicht die Sprache seiner Reflexionen und seiner Kunst war, spürte der Schriftsteller eine starke Anziehung zur italienischen Sprache, die ihn oft zwischen Scherz und Emst sagen ließ, seine Bücher seien auf italienisch schöner.
Die Gefühle Rezzoris Italien entgegen sind unmittelbar mit seiner späteren Lebensweise in dem alten Haus in der Toskana verbunden. Es ist ein verinnerlichtes Italien, wohin der Autor immer wieder zurückkehrt und wo, trotz allem, noch die Zitronen blühen, und die Freundschaft dazu.
Rezzori face à l’histoire : Vienne, mars 1938
Authors: Lajarrige Jacques 
Published: July 2024

„Léo prêt pour le voyage“ : comme l’on sait, le nom de code pour signaler que la Wehrmacht était prête à envahir l’Autriche ne resta pas longtemps lettre morte. En mars 1938, Gregor von Rezzori, qui n’avait à l’époque que vingt-quatre ans, assista au milieu de la foule en liesse amassée sur la Place des Héros à l’arrivée triomphale d’Hitler à Vienne. Cette scène ne laissa pas seulement dans la mémoire du jeune homme une empreinte indélébile, elle devint par la suite également le leitmotiv obsédant, pour ne pas dire le moteur même, de ses «autobiographies hypothétiques» comme de ses véritables mémoires.
En partant du roman polymorphe La mort de mon frère Abel, on s’efforce ici d’analyser les différentes formes d’apparition de ces journées fatidiques à l’intérieur d’une structure narrative complexe, ainsi que les indices afférents qui laissent entrevoir une interprétation cohérente de l’Histoire de la part de Rezzori.
On se rend ainsi compte que le témoin oculaire et visuel que fut Rezzori, alors citoyen roumain, prend avec provocation ses distances avec le manque de maturité historique et politique de son narrateur, le jeune dandy et coureur de jupons Aristides Subciz, double littéraire dont il démasque les fausses excuses.
À l’aide d’exemples concrets, on propose ensuite l’hypothèse selon laquelle l'Anschluß a donné à Rezzori l’occasion de nouer avec les Aufzeichnungen de Canetti, et plus encore avec Masse und Macht un dialogue malicieux, dont les accents polémiques sont soumis dans ses deux derniers réglementes de compte avec lui-même, Greisengemurmel et Mir auf der Spur, à un réexamen qui, pour être résolument autocritique, n’a rien perdu de sa virulence.
« Prendre le spectateur de front ». Sur le nouveau documentaire autrichien : Sauper, Geyrhalter, Seidl, Salmonowitz
Authors: Niney François 
Published: July 2024

Den Zuschauer frontal angehen (über den neuen österreichischen Dokumentarfilm : Sauper, Geyrhalter, Seidl, Salmonowitz)
Filme wie Darwin’s Albtraum (2005) von Hubert Sauper, Unser täglich Brot (2006) von Nikolaus Geyrhalter oder Good News (1989) und Dog Days (2000) von Ulrich Seidl, oder auch Kurz davor ist es passiert (2007) von Anja Salomonowitz haben bei der Kritik für Aufregung und Entsetzen gesorgt. Allen ist gemeinsam, dass sie direkt, auf demonstrative Weise vorgehen, indem sie eine Art negative Pädagogik einsetzen, die den Zuschauer mit der Häßlichkeit der von ihm bewohnten, jedoch ungern betrachteten Welt konfrontiert. Sie bieten keinerlei Gegenleistung, sic lehnen die Erlösung des Wirklichen durch das Bild ab.
Die dokumentarische Herausforderung liegt nicht mehr in der Information des Zuschauers über die verheerenden Folgen der Weltordnung (die dieser wissentlich ignoriert), sondern darin, dessen freiwillige Knechtschaft anzugehen und sein falsches Bewußtsein in die Flucht zu schlagen, sei es durch Mangel (Minimalismus, Litotes, Ironie), sei es durch Übertreibung (Groteske, Horror, Provokation). In jedem Falle werden dabei die Rezeptionsgewohnheiten, aber auch die Konventionen der dokumentarischen wie der fiktionalen Erzählungen vereitelt.
„Lebe wohl und frei!“ Epigonale Existenzen zwischen Fremd- und Selbstbestimmung im Roman Radetzkymarsch
Authors: Steinmann Esther 
Published: July 2024

“Fare well and be free !” Epigonal Existences in the Novel Radetzky March : Towards a Self-determinated Way of Living.
This contribution considers how Radetzky March portrays the dramatic historical upheavals, the change in perspectives and values, and the figure of end and renewal. The novel’s protagonist, Carl Joseph, is not only the youngest Trotta, but also the last. He experiences the decline on a grand scale in the end of the Austrian-Hungarian monarchy as well as the decline on a smaller scale, in his own tragic end, which is also the end of his dynasty. The world-historical and personal catastrophes, however, do not just entail a loss of familiar values systems. At the same time, new modes of thought and action begin to emerge which allow a more authentic, liberated and self-determined way of living. Farewell and renewal are compressed in the appeal to fare well and be free („Lebe wohl und frei !“).
Fins de romans, fins d’un monde. Le Temps retrouvé, La Marche de Radetzky, Le Guépard
Authors: Godeau Florence 
Published: July 2024

Roman-Ende, Ende einer Welt.
In diesem Artikel vergleichen wir das Ende von Radetzkymarsch von Joseph Roth und das Ende von zwei anderen Romanen, die das „Ende einer Welt “ beschrieben haben : Le Temps retrouvé von Marcel Proust, und II Gattopardo von Giuseppe Tomasi di Lampedusa. Diese drei Romane sind eben durch mehrere Beziehungen und Analogien verbunden. Was in diesem Corpus sofort auffällt, ist nämlich nicht nur die Allgegenwart des zentralen Motivs vom „Ende einer Welt“ (ein interpretatorisch ergiebiger Ausdruck, der zu verschiedenen Lektüren anregt), sondern eine ähnliche narrative Spannung. Das Ende nimmt in diesen Romanen ein solches Ausmaß, dass man behaupten könnte, dass die ganze Geschichte sich aus ihren letzten Seiten heraus konstruiert. Im vorliegenden Beitrag soll diese „Ästhetik des Endes“ vor allem in Bezug auf ihre poetische Umsetzung analysiert werden.