bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired metal perception and regulation of associated human foliate papillae tongue transcriptome in long-COVID-19
Authors: Danzer Barbara , Jukic Mateo , Dunkel Andreas , Andersen Gaby , Lieder Barbara , Schaudy Erika , Stadlmayr Sarah , Lietard Jory , Michel Timm , Krautwurst Dietmar , Haller Bernhard , Knolle Percy , Somoza Mark , Lingor Paul , Somoza Veronika 
Published: July 2024

AbstractChemosensory impairment is an outstanding symptom of SARS-CoV-2 infections. We hypothesized that measured sensory impairments are accompanied by transcriptomic changes in the foliate papillae area of the tongue. Hospital personnel with known SARS-CoV-2 immunoglobulin G (IgG) status completed questionnaires on sensory perception (n = 158). A subcohort of n = 141 participated in forced choice taste tests, and n = 43 participants consented to donate tongue swabs of the foliate papillae area for whole transcriptome analysis. The study included four groups of participants differing in IgG levels (≥ 10 AU/mL = IgG+; < 10 AU/mL = IgG-) and self-reported sensory impairment (SSI±). IgG+ subjects not detecting metallic taste had higher IgG+ levels than IgG+ participants detecting iron gluconate (p = 0.03). Smell perception was the most impaired biological process in the transcriptome data from IgG+/SSI+ participants subjected to gene ontology enrichment. IgG+/SSI+ subjects demonstrated lower expression levels of 166 olfactory receptors (OR) and 9 taste associated receptors (TAS) of which OR1A2, OR2J2, OR1A1, OR5K1 and OR1G1, as well as TAS2R7 are linked to metallic perception. The question raised by this study is whether odorant receptors on the tongue (i) might play a role in metal sensation, and (ii) are potential targets for virus-initiated sensory impairments, which needs to be investigated in future functional studies.
Baseline data collections of lipopolysaccharide content in 414 herbal extracts and its role in innate immune activation
Authors: Tjendana Tjhin Vindy , Oda Masataka , Yamashita Masashi , Iwaki Tomoko , Fujita Yasuko , Wakame Koji , Inagawa Hiroyuki , Soma Gen-Ichiro 
Published: July 2024

AbstractSome herbal extracts contain relatively high amounts of lipopolysaccharide (LPS). Because orally administered LPS activates innate immunity without inducing inflammation, it plays a role as an active ingredient in herbal extracts. However, the LPS content in herbal extracts remains extensively unevaluated. This study aimed to create a database of LPS content in herbal extracts; therefore, the LPS content of 414 herbal extracts was measured and the macrophage activation potential was evaluated. The LPS content of these hot water extracts was determined using the kinetic–turbidimetric method. The LPS concentration ranged from a few ng/g to hundreds of μg/g (Standard Escherichia coli LPS equivalent). Twelve samples had a high-LPS-content of > 100 μg/g, including seven samples from roots and three samples from leaves of the herbal extracts. These samples showed high phagocytosis and NO production capacity, and further investigation using polymyxin B, an LPS inhibitor, significantly inhibited macrophage activation. This study suggests that some herbal extracts contain sufficient LPS concentration to activate innate immunity. Therefore, a new approach to evaluate the efficacy of herbal extracts based on their LPS content was proposed. A database listing the LPS content of different herbal extracts is essential for this approach.
Dynamic look-ahead feedrate scheduling method based on sliding mode velocity control
Authors: Wang Liuquan , Liu Qiang , Sun Pengpeng , Lv Shisheng , Yang Ruijie , Yang Zhiqi 
Published: July 2024

AbstractIn the feedrate scheduling of complex curve direct interpolation, dynamic constraints such as axis acceleration and jerk are related to the actual state of the tool. Most existing methods convert dynamic constraints to velocity constraints at sampling points. However, it cannot guarantee the dynamic constraints are satisfied between sampling points. Addressing the issue, this paper proposes a dynamic look-ahead feedrate scheduling method based on sliding mode velocity control, which generates the motion command considering dynamic constraints in every interpolation cycle. To dynamically generate commands based on the current tool state, the acceleration and deceleration method based on sliding mode velocity control has been proposed, which can control tool state to transition to the command state with any initial state. To ensure sufficient distance for acceleration and deceleration, this paper uses braking distance to dynamically estimate the look-ahead distance. Then the minimum value within the look-ahead interval is selected as the command velocity for this scheduling cycle and the actual motion command is determined based on the dynamic constraints of each axis. Simulation and experiment results prove that compared with the existing method, this method effectively reduces the overshoot of dynamic constraints without significantly increasing the machining time. The analysis of real-time computation time has demonstrated the potential of the method proposed in this paper for real-time applications.
Helminths of the black-headed gull (Chroicocephalus ridibundus) from breeding colonies in north-central Poland
Authors: Stapf Agata N. , Rząd Izabella , Królaczyk Katarzyna , Indykiewicz Piotr , Gruszka Wojciech 
Published: July 2024

AbstractAmong parasites of the digestive tract of the black-headed gull (Chroicocephalus ridibundus) in Poland, the best known are species of digenetic trematodes and cestodes. Nematodes of this bird species are not well known. Black-headed gulls, due to their varied diet, migration, life in a flock, and changes of habitat, can become infected with various species of helminths, and like synanthropic birds, they can spread the dispersal stages of parasites across urban and recreational areas. In the present study, an attempt was made to identify the helminth fauna of C. ridibundus from breeding colonies in north-central Poland. The aim of the study was to describe the taxonomic structure of parasites of the digestive tract of the black-headed gull and determine the quantitative parameters of their occurrence. A total of 43 black-headed gulls were examined post-mortem for gastrointestinal helminths, resulting in the identification of four cestodes (Paricterotaenia porosa, Lateriporus clerci, Anomotaenia micracantha, and Wardium fusum), three trematodes (Diplostomum pseudospathaceum, Plagiorchis laricola, and Apophallus muehlingi), and three nematodes (Eucoleus contortus, Cosmocephalus obvelatus, and Porrocaecum ensicaudatum). Lateriporus clerci (in adult form), C. obvelatus and P. ensicaudatum (in larval form) were recorded for the first time in the black-headed gull in Poland.
The effect on the equilibrium sickle cell allele frequency of the probable protection conferred by malaria and sickle cell gene against other infectious diseases
Authors: Habibzadeh Farrokh 
Published: July 2024

AbstractIf a mutated gene with heterozygous advantage against malaria, e.g., hemoglobin S (HbS) gene, is introduced in a small tribe, the gene (allele) frequency (fgene) increases until it reaches a steady state value (feq) where the total mortality from malaria and sickle cell disease is a minimum. This is a classic example of balanced-polymorphism named malaria hypothesis. In a previous in silico study, assuming realistic initial conditions, it has been shown that the feq is around 14%, far less than the fgene observed in certain parts of Africa, 24%. It seems that the malaria hypothesis, per se, could not explain such a high fgene, unless it is assumed that malaria and HbS gene can provide protection against other diseases. Using Monte-Carlo simulation, the current study was conducted to examine the effect on feq of five scenarios was examined. The studied scenarios consisted of different combinations of mortality of other diseases and the possible amounts of protections conferred by malaria and HbS gene against the diseases. Taking into account other diseases causing mortality in the population makes the fgene rate of change steeper over generations. feq is an increasing function of the amount of protection conferred by HbS gene against other diseases. The effect of protection provided by malaria against other diseases on feq, is however, variable—depending on the amount of protection conferred by HbS gene against other diseases, it may increase or decrease feq. If malaria and HbS gene provide protections of 1.5-fold and threefold against other diseases, respectively, the feq is around 24%, the amount reported in certain tribes of Africa. Under certain scenarios, the feq attained is even higher.
Anti-hyperuricemia effect of Clerodendranthus spicatus: a molecular biology study combined with metabolomics
Authors: Zhou Zheng , Xu Manfei , Bian Meng , Nie Anzheng , Sun Bao , Zhu Chunsheng 
Published: July 2024

AbstractHyperuricemia (HUA), a metabolic disease caused by excessive production or decreased excretion of uric acid (UA), has been reported to be closely associated with a variety of UA transporters. Clerodendranthus spicatus (C. spicatus) is an herbal widely used in China for the treatment of HUA. However, the mechanism has not been clarified. Here, the rat model of HUA was induced via 10% fructose. The levels of biochemical indicators, including UA, xanthine oxidase (XOD), adenosine deaminase (ADA), blood urea nitrogen (BUN), and creatinine (Cre), were measured. Western blotting was applied to explore its effect on renal UA transporters, such as urate transporter1 (URAT1), glucose transporter 9 (GLUT9), and ATP-binding cassette super-family G member 2 (ABCG2). Furthermore, the effect of C. spicatus on plasma metabolites was identified by metabolomics. Our results showed that C. spicatus could significantly reduce the serum levels of UA, XOD, ADA and Cre, and improve the renal pathological changes in HUA rats. Meanwhile, C. spicatus significantly inhibited the expression of URAT1 and GLUT9, while increased the expression of ABCG2 in a dose-dependent manner. Metabolomics showed that 13 components, including 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PE, Tyr-Leu and N-cis-15-Tetracosenoyl-C18-sphingosine, were identified as potential biomarkers for the UA-lowering effect of C. spicatus. In addition, pathway enrichment analysis revealed that arginine biosynthesis, biosynthesis of amino acids, pyrimidine metabolism and other metabolic pathways might be involved in the protection of C. spicatus against HUA. This study is the first to explore the mechanism of anti-HUA of C. spicatus through molecular biology and metabolomics analysis, which provides new ideas for the treatment of HUA.
Loss of miR-145 promotes remyelination and functional recovery in a model of chronic central demyelination
Authors: Kornfeld Samantha F. , Cummings Sarah E. , Yaworski Rebecca , De Repentigny Yves , Gagnon Sabrina , Zandee Stephanie , Fathi Samaneh , Prat Alexandre , Kothary Rashmi 
Published: July 2024

AbstractStrategies for treating progressive multiple sclerosis (MS) remain limited. Here, we found that miR-145-5p is overabundant uniquely in chronic lesion tissues from secondary progressive MS patients. We induced both acute and chronic demyelination in miR-145 knockout mice to determine its contributions to remyelination failure. Following acute demyelination, no advantage to miR-145 loss could be detected. However, after chronic demyelination, animals with miR-145 loss demonstrated increased remyelination and functional recovery, coincident with altered presence of astrocytes and microglia within the corpus callosum relative to wild-type animals. This improved response in miR-145 knockout animals coincided with a pathological upregulation of miR-145-5p in wild-type animals with chronic cuprizone exposure, paralleling human chronic lesions. Furthermore, miR-145 overexpression specifically in oligodendrocytes (OLs) severely stunted differentiation and negatively impacted survival. RNAseq analysis showed altered transcriptome in these cells with downregulated major pathways involved in myelination. Our data suggest that pathological accumulation of miR-145-5p is a distinctive feature of chronic demyelination and is strongly implicated in the failure of remyelination, possibly due to the inhibition of OL differentiation together with alterations in other glial cells. This is mirrored in chronic MS lesions, and thus miR-145-5p serves as a potential relevant therapeutic target in progressive forms of MS.
Ultrabroadband valley transmission and corner states in valley photonic crystals with dendritic structure
Authors: Li Meize , Liu Yahong , Du Lianlian , Li Peng , Dong Yibao , Tao Liyun , Li Zhenfei , Guo Yao , Song Kun , Zhao Xiaopeng 
Published: July 2024

AbstractIn photonic crystal systems, topologically protected edge states and corner states can be achieved by breaking spatial inversion symmetry, which is expected to be applied to topologically protected lasers, optical communication and integrated photonics. However, designing ultrabroadband topological photonic crystals is still a challenge. In this work, we propose a valley photonic crystal composed of dendritic structures, which can realize valley transmission with a relative bandwidth up to 59.65%. Compared with the previously reported two-dimensional broadband photonic crystals with 32.02% bandwidth, the relative bandwidth of the proposed valley transmission is increased by almost 100%. Theoretical analysis, numerical simulation and experimental measurement all confirm flexible manipulation of electromagnetic wave propagation paths. Ultrabroadband topological waveguides with the zigzag and armchair interface are demonstrated, which can achieve experimentally 58.71% and 36.78% relative bandwidth, respectively. In addition, several topological channel intersections are designed. Finally, two types of corner states with valley switchability and selectivity are demonstrated.
The interplay of chromophore–spacer length in light-induced gold nanocluster self-assembly
Authors: Rival Jose V. , Nonappa  , Shibu Edakkattuparambil Sidharth 
Published: July 2024

The chromophore-spacer length controls the cis-trans isomerization of azobenzene ligands in precision nanoclusters and regulates the kinetics of self-assembled superstructure formation.
Recognition of European mammals and birds in camera trap images using deep neural networks
Authors: Schneider Daniel , Lindner Kim , Vogelbacher Markus , Bellafkir Hicham , Farwig Nina , Freisleben Bernd 
Published: July 2024

AbstractMost machine learning methods for animal recognition in camera trap images are limited to mammal identification and group birds into a single class. Machine learning methods for visually discriminating birds, in turn, cannot discriminate between mammals and are not designed for camera trap images. The authors present deep neural network models to recognise both mammals and bird species in camera trap images. They train neural network models for species classification as well as for predicting the animal taxonomy, that is, genus, family, order, group, and class names. Different neural network architectures, including ResNet, EfficientNetV2, Vision Transformer, Swin Transformer, and ConvNeXt, are compared for these tasks. Furthermore, the authors investigate approaches to overcome various challenges associated with camera trap image analysis. The authors’ best species classification models achieve a mean average precision (mAP) of 97.91% on a validation data set and mAPs of 90.39% and 82.77% on test data sets recorded in forests in Germany and Poland, respectively. Their best taxonomic classification models reach a validation mAP of 97.18% and mAPs of 94.23% and 79.92% on the two test data sets, respectively.
10 kV nanosecond pulse generator with high voltage gain and reduced switches
Authors: Ma Jiuxin , Yu Liang , Yao Chenguo , Dong Shoulong , Li Chengxiang , Ren Lvheng , Wang Shixin 
Published: July 2024

AbstractIn the article, a new type boost high‐voltage nanosecond pulse generator is proposed. The distributed inductance of the transmission line is utilised as the energy storage unit and cooperated with the variable impedance transmission line transformer to generate nanosecond pulses with extremely high‐voltage gain. What’s more, the isolation effect caused by the transmission line time delay is applied to achieve modular stacking. The demand for charging power supply can be greatly reduced, and few switches are used. Finally, the topological principle is verified by experiments, and a prototype of the five‐stage stacking prototype is built. With the charging voltage of 28 V, the generator can output pulse with a voltage amplitude of 10 kV and pulse width of 12 ns whose voltage gain is up to 357 times.
Wearable micro‐electro‐mechanical systems pressure sensors in health care: Advancements and trends—A review
Authors: Kiran Kolluri S. S. , Ananiah Durai S. 
Published: July 2024

AbstractWearable technologies offer a complementary approach to clinical diagnostics by utilising a variety of physical, chemical, and biological sensors to mine physiological (biophysical and/or biochemical) data in real time (preferably continuous), in a non‐intrusive or minimally invasive manner. Micro‐Electro‐Mechanical Systems (MEMS) pressure sensors dominate the healthcare applications especially for vital parameter sensing, as they feature the non‐invasive method of diagnosis and have comparatively high sensitivity leading to better accuracy. Among them, capacitive and piezoresistive type pressure sensors have gained substantial advantages compared to other transduction devices due to high linearity, low power consumption, and low thermal coefficient. The performance review of such MEMS sensors in research and as well as market‐ready devices that can be seamlessly integrated into commercial wearable products is the primary focus in this work. Challenges in the system level integration of Microsensors with the associated interface electronics and the design mitigation of such MEMS microsystems are also discussed. Design insights of analog front‐end circuitry in terms of gain, noise, power and area that are crucial for any wearable applications are also comprehensively reviewed.
Multiwavelength study of on-disk coronal-hole jets with IRIS and SDO observations
Authors: Koletti M. , Gontikakis C. , Patsourakos S. , Tsinganos K. 
Published: July 2024

Context. Solar jets are an important field of study, as they may contribute to the mass and energy transfer from the lower to the upper atmosphere.
Aims. We use the Interface Region Imaging Spectrograph (IRIS) and Solar Dynamic Observatory (SDO) observations to study two small-scale jets (jet 1 and jet 2) originating in the same on-disk coronal hole observed in October 2013.
Methods. We combine dopplergrams, intensity maps, and line width maps derived from IRIS Si IV 1393.755 Å spectra along with images from the Atmospheric Imaging Assembly (AIA) on SDO to describe the dynamics of the jets. Images from AIA, with the use of the emission measure loci technique and rectangular differential emission measure (DEM) distributions, provide estimations of the plasma temperatures. We used the O IV 1399.77 Å, 1401.16 Å spectral lines from IRIS to derive electron densities.
Results. For jet 1, the SDO images show a small mini-filament 2 minutes before the jet eruption, while jet 2 originates at a pre-existing coronal bright point. The analysis of asymmetric spectral profiles of the Si IV 1393.755 Å and 1402.770 Å lines reveals the existence of two spectral components at both regions. One of the components can be related to the background plasma emission originating outside the jet, while the secondary component represents higher-energy plasma flows associated with the jets. Both jets exhibit high densities of the order of 1011 cm−3 at their base and 1010 cm−3 at the spire, respectively, as well as similar average nonthermal velocities of ∼50–60 km/s. However, the two jets show differences in their length, duration, and plane-of-sky velocity. Finally, the DEM analysis reveals that both jets exhibit multithermal distributions.
Conclusions. This work presents a comprehensive description of the thermal parameters and the dynamic evolution of two jets. The locations of the asymmetric profiles possibly indicate the areas of energy release triggering the jets.
Was wissen Sie über … die Wirbelsäule?
Authors: Schmid Eva C. 
Published: July 2024

SummaryLiebe Leser, testen Sie Ihr Wissen und frischen Sie Ihre Kenntnisse auf. Bitte kreuzen Sie jeweils eine Antwort an. Viel Spaß beim Beantworten wünscht Ihnen HP Eva C. Schmid!
Quality of endoscopic surveillance of Lynch syndrome patients in a Swedish cohort
Authors: Walton Bernstedt Sophie , Haxhijaj Adrianna , Jamizadeh Nigin , Björk Jan , Andreasson Anna , Forsberg Anna M , Backman Ann-Sofie 
Published: July 2024

Abstract
Background and study aims Risk factors for colorectal cancer (CRC) in Lynch syndrome (LS) include sex, age, smoking, high body mass index (BMI), surveillance interval length, and risk genotype. The Boston Bowel Preparation Scale (BBPS) produces a standardized bowel cleanliness rating. A low BBPS score might be a risk factor for missed early lesions. The aim of this study was to investigate the correlation between BBPS score and adenoma detection (with known risk factors for CRC) and surveillance interval with CRC detection in LS patients.
Methods A retrospective cohort study including 366 LS patients with 1,887 colonoscopies under surveillance in Stockholm, Sweden from 1989 to 2021 was conducted. Associations were tested using linear and logistic regression.
Results We found no association between BBPS score and number of
adenomas detected. A low BBPS score was found to be associated with older age (regression
coefficient (coeff) –0.015; 95% confidence interval [CI] –0.026 to –0.004; P = 0.007) and obesity (coeff = –0.48; 95% CI: –0.89 to –0.062; P = 0.024). A higher number of detected adenomas was associated with older age
(coeff = 0.008; 95% CI 0.004 to 0.012; P < 0.001), male sex
(coeff = 0.097; 95% CI 0.008 to 0.19; P = 0.033) and CRC (coeff =
0.28; 95% CI 0.061 to 0.50; P = 0.012). Surveillance interval
length was not significant in CRC detection.
Conclusions Bowel cleanliness was not associated with adenoma detection and was less likely achieved in patients who were older and had higher BMI. Adenoma detection was associated with older age and male sex. The results indicate the need for better adherence to guidelines and attention to older age groups, men, and patients with obesity.
Palladium-Catalyzed Domino Heteroarylation of Thioamides: A Simple Route to Benzothieno[2,3-b]quinolones
Authors: Peruncheralathan Saravanan , Janni Manojkumar , Thirupathi Annaram , Subramaniam Subhashini V. 
Published: July 2024

AbstractDomino reactions are essential for advancing organic synthesis. This study introduces novel thioamide-based precursors for a palladium-catalyzed selective domino heteroarylation process. The method efficiently produces benzothieno[2,3-b]quinolones with yields ranging from moderate to very good. By employing aryl chlorides, the efficiency of the domino hetero-annulation process is comparable to that of aryl bromides. Executing a one-pot, two-step reaction also delivered a single domino product with high selectivity. The strategy involved fine-tuning substituent reactivity, utilizing electron-rich arenes, and forming metallocycles with nucleophilic sulfur, consistently yielding a single product. The proposed mechanism is corroborated by mechanistic studies.