bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Assessment of Gutta-Percha Removal Techniques for Endodontic Retreatment: Efficiency and Clinical Implications
Authors: Asiri Ashwaq 
Published: August 2024

Background: Endodontic retreatment involves the removal of gutta-percha and sealer from root canals to address treatment failures and persistent infections. This study aimed to systematically evaluate and compare the effectiveness of different gutta-percha removal techniques.Methods: Sixty extracted human teeth with single canals were selected. The canals were initially treated, obturated with gutta-percha, and divided into six groups (n=10 each). Each group represented a distinct removal technique: rotary instrument-driven, Gates-Glidden drill-assisted, solvent-based dissolution, ultrasonic removal, heat-based softening, and a control group. Gutta-percha mass and canal wall cleanliness were assessed post-removal. Statistical analyses were performed using ANOVA and post hoc Tukey's HSD tests.Results: The solvent-based dissolution technique exhibited the most efficient removal, achieving the lowest mean remaining gutta-percha mass (0.89 ± 0.15 mg) and the highest canal wall cleanliness (95% ± 3%). The ultrasonic technique also showed effective removal capabilities with a mean remaining mass of 1.56 ± 0.22 mg and a cleanliness of 89% ± 4%. The rotary technique resulted in a mean mass of 2.47 ± 0.30 mg and cleanliness of 84% ± 5%. Gates-Glidden drill-assisted and heat-based techniques showed moderate performance with remaining masses of 3.18 ± 0.25 mg and 2.10 ± 0.20 mg, respectively, and cleanliness percentages of 78% ± 6% and 81% ± 5%. The control group had the highest remaining mass (9.88 ± 0.42 mg) and the lowest cleanliness (10% ± 2%), confirming the efficacy of the removal techniques.Conclusion: The solvent-based dissolution technique demonstrated superior efficacy in gutta-percha removal. Ultrasonic and rotary techniques were also effective choices. Clinicians should consider these findings when selecting gutta-percha removal methods for endodontic retreatment procedures.Keywords: Endodontic retreatment; Gutta-Percha removal; Canal wall cleanliness; Comparative efficacy; Removal techniques
Evaluation of Micro-RNA Expression Profiling Level as Biomarkers for Diagnosis and Gene Sequencing in Patients Suffering from Breast Cancer
Authors: Al-Rikabi Rasha H. , Fares Nagui H. , AL Faham Mahmmad A. , Abdel Wahab Abdel Hady A. 
Published: August 2024

Background: Human bloodstream microRNAs (miRNAs) have emerged as a promising predictive and diagnostic biomarker for a range of cancers, including breast cancer. Our objective was to look into new miRNA biomarkers for diagnosis in the serum of patients with breast cancer and track the expression levels at different stages using miRNA profiling.Methods: 53 breast cancer patients and 10 healthy controls had blood samples tested for three miRNAs. miRNAs were extracted from blood and evaluated using real-time quantitative polymerase chain reaction. After extracting genomic DNA, miRNA primer-produced PCR products were sequenced to discover point mutations that may contribute to the illness.Results: After examining miR195, miR200b, and miR331, breast cancer patients had a significantly lower miR195 level than healthy persons. In addition, miR200b expression levels were significantly lower in breast cancer patients than in healthy individuals. In advanced stages, miR331 expression was substantially higher than in healthy people.Conclusion: The findings of our study demonstrated a significant association between the expression of miRNAs and the prognosis of breast cancer. Additional research is necessary to study better the correlation between these circulating miRNAs and the stages of breast cancer.Keywords: Breast cancer; Circulating miRNAs; miR195; miR200b; miR331 RT PCR; Gene Sequencing
Serum 25-Hydroxy Vitamin D and Uric Acid Levels as Predictors of Disease Severity and Functional Impairment in Women with Knee Osteoarthritis
Authors: Gharib Amal F. , Alsaiari Ahad A. , Alshamrani Renad A. , Al-Qahtani Norah M. , Almalki Abdulraheem , Alsalmi Ohud , Almehmadi Mazen , Al harthi Norah , Hassan Asmaa F. , Alsulimani Alaa Hamid , Abdelhady Enas I. , Nafea Ola 
Published: August 2024

Background: The most frequent type of arthritis is osteoarthritis; it typically develops slowly and is more frequently observed in older adults. Osteoarthritis mainly affects weight-bearing joints but other can also affected joints. The purpose of the study was to explore the associations between serum of 25-hydroxy vitamin D (25(OH)D) and serum uric acid (SUA) with serum lipid profiles and inflammatory cytokines in women with KOA and to scrutinize the prognostic potential of serum 25(OH)D and SUA.Methods: The study involved 50 elderly obese females with KOA and the control group of 50 healthy women. Assessment of KOA severity by Kellgren-Lawrence score was performed and functional disability was scored. Blood samples were analysed to assess 25(OH)D and inflammatory cytokines, SUA, lipid profile, and calcium.Results: We found significant differences in most of the laboratory findings between KOA patients and controls. Decreased serum 25(OH)D and increased SUA were linked with more severe KOA. Serum 25(OH)D and SUA can differentiate between mild and moderate-to-severe KOA. Both were correlated with functional impairment.Conclusions: We concluded robust associations between vitamin D deficiencies, high SUA levels with increased serum lipids and inflammatory cytokines along with increased functional impairment and disease severity in women with KOA. Serum 25(OH)D and SUA can serve as simple reliable prognostic tools in the prediction of KOA severity.Keywords: Vitamin D; Inflammation; Osteoarthritis; Serum lipids; Uric acid TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//
Antidiabetic Activity and Pancreatic Histopathology Analysis of Averrhoa bilimbi L. Leaves Extract on Alloxan-Induced Diabetes on Wistar Mice
Authors: Intan Solikhah Tridiganita , Kusnandar Miftakhurrozaq Ragil , Rafif Khairullah Aswin 
Published: August 2024

Background: Diabetes mellitus is a multi-etiological metabolic disorder characterized by chronic hyperglycemia, total or relative insulin deficiency, and further complications by metabolic disorders. Drug therapy for diabetes mellitus is costly and fraught with potential side effects. The aim of this research is to investigate antidiabetic and histopathological analysis of ethanolic A. bilimbi leaves extract in alloxan induced diabetic mice.Methods: Wuluh starfruit leaves is one of Indonesia's plants that can be used to treat diabetes mellitus. Thirty male Wistar mice were divided into five groups as follows: Negative control group that didn't receive any treatment, Diabetes control group that received alloxan 150 mg/kg, Positive control group that received glibenclamide 600 μg/kg, and lastly the two test groups that received A. bilimbi leaves extract 150 and 300 mg/kg orally for 14 days. After extract administration, blood glucose and histopathological alterations in the pancreas of diabetic mice were observed.Results: Alloxan to the diabetes control group significantly raised blood glucose levels compared to the negative control group. Administration of wuluh starfruit leaves extract and glibenclamide could significantly lower blood sugar levels compared to the diabetic control group. Administration of wuluh starfruit leaves extract treatment and glibenclamide also showed favorable effect on the histopathological changes of the pancreas in alloxan induced diabetes.Conclusion: The study concludes the administration of wuluh starfruit leaves extract (150 and 300 mg/kg) and glibenclamide could reduce blood glucose levels and can help with cell regeneration and protecting pancreatic cells from damage caused by alloxan.Keywords: A. bilimbi leaves extract; Alloxan; Diabetes; Pancreatic histopathology
Use of Biological Agents to Control the Number of Halyomorpha halys Stål
Authors: Agasyeva Irina S. , Ismailov Vladimir Ya. , Petrishcheva Maria , Nastasiy Anton S. 
Published: August 2024

Background: Halyomorpha halys Stål, commonly known as the brown marmorated stink bug, poses a significant threat to various crops, necessitating repeated seasonal insecticide applications for control. However, these methods carry environmental and human health risks. Considering these concerns, there is a pressing need to explore alternative, eco-friendly approaches to managing H. halys populations. This study sets out to investigate innovative strategies that minimize reliance on harmful chemicals while still effectively controlling the stink bug menace. By delving into the realm of sustainable pest management, the aim is to develop methods that strike a balance between pest control efficacy and environmental stewardship. This study aims to explore eco-friendly approaches to managing H. halys populations.Methods: The research involved monitoring the population dynamics of H. halys in the central zone of the Krasnodar Territory, Russia. It also evaluated the efficacy of local parasitic insects Pediobius cassidae and Anastatus bifasciatus in reducing pest infestations, conducted laboratory tests on the insecticidal properties of essential oils from plants such as wormwood, coriander, and Siberian fir, and performed field trials on biological control agents.Results: Infestation rates by parasitic insects remained relatively low, ranging from 5-10%. Laboratory experiments demonstrated the potent insecticidal properties of essential oils derived from wormwood, coriander, and Siberian fir. Field trials further confirmed significant mortality rates of H. halys specimens when exposed to biological control agents.Conclusions: The study underscores the potential efficacy of utilizing parasitic insects and plant-derived essential oils in managing H. halys populations. These findings offer practical insights for promoting sustainable agricultural practices in the central zone of the Krasnodar Territory.Keywords: Brown marmorated stink bug; Biorational insecticides; Essential oils
MODERASI BERAGAMA DALAM MENINGKATKAN SIKAP MODERAT DI KALANGAN GENERASI MUDA
Authors: Muttaqin Ahmad Izza 
Published: August 2024

Pendampingan ini bertujuan untuk memberikan pemahaman tentang moderasi beragama, pengalaman empiris dan cara-cara menangkalnya bagi strategi penguatan serta implementasi moderasi beragama di MTs Negeri 08 Banyuwangi. Tempat pendampingan dipilih dengan pertimbangan bahwa sekolah tersebut berada di tengah kota yang pemahaman siswa terkait dengan wacana-wacana moderasi beragama masih rendah. Sehingga banyak dari siswanya yang cenderung “tidak peduli” dengan paham-paham tersebut. Metode yang digunakan dalam pendampingan ini adalah metode RRA dengan menggunakan model triangular. Pelaksanaan pendampingan ini dimulai dari tahap perencanaan kegiatan, pendampingan, seminar moderasi beragama dan perencanaan diskusi mandiri mingguan tentang moderasi beragama.
PENYULUHAN DAN PELATIHAN ARAH KIBLAT DALAM PENGEMBANGAN FIKIH SAINS ASTRONOMI BAGI TAKMIR MASJID PADA DAERAH PEGUNUNGAN
Authors: Muhajir Muhajir 
Published: August 2024

Sejauh ini permasalahan tentang arah kiblat belum tersentuh oleh pemerintah, padahal masih banyak ditemukan problematika tentang Ilmu Falak terutama pada kalangan agamawan, baik para pengurus takmir masjid maupun masyarakat umum. maka melalui program pengabdian kepada masyarakat ini berusaha untuk menfasilitasi diadakannya penyuluhan dan pelatihan tentang penentuan arah kiblat dalam rangka untuk memperdalam dan mempertajam wawasan Falakiyah baik secara teoritik maupun praktis bagi masyarakat terutama takmir masjid di kawasan pegunungan desa cacaban kidul kecamatan bener kabupaten Purworejo, agar ibadahnya lebih sempurna dan benar menurut syariah. Metodologi pengabdian masyarakat dilaksanakan di desa cacaban kidul kecamatan bener kabupaten purworejo dengan menggunakan pendekatan partisipatif. Dalam pelaksanaan pelatihan dan penyuluhan arah kiblat bagi takmir masjid dan mushola, Program penyuluhan dan pelatihan ini akan dilaksanakan oleh dosen falak STAI An-Nawawi Purworejo dan dibantu oleh ta’mir masjid disekitar lokasi pengabdian.Hasil pengabdian ini yaitu bahwa Pemahaman takmir masjid dalam menentukan kiblat masjid masih berdasar pada peninggalan pendahulu, Mengikuti bangunan masjid lainnya yang sudah ada. Kegiatan penyuluhan dan pelatihan dilakukan melalui beberapa tahap dengan melibatkan para Takmir masjid, imam masjid, pemuda dan perangkat desa. Dengan kegiatan ini diharapkan para peserta masyarakat dapat mempraktikannya di rumah masing-masing sehingga nantinya ruang ibadah nya telah sesuai dengan arah kiblat, tidak lagi menyesuaikan dengan bangunan masjid maupun mushola.
Interannual variations in river water content and distribution over the Laptev Sea between 2007 and 2011: The Arctic Dipole connection
Authors: Thibodeau Benoit , Bauch Dorothea , Kassens Heidemarie , Timokhov Leonid A. 
Published: September 2014

AbstractFive years of oxygen isotope and hydrological surveys reveal interannual variations in the inventory and distribution of river water over the Laptev Sea. In 2007, 2009, and 2010 relatively low amounts of river water (≤1500 km3) were found and were mostly located in the southeastern Laptev Sea. In 2008 and 2011, high amounts of river water (~1600 km3 and ~2000 km3) were found, especially in the central and northern part of the shelf, suggesting a northward export of this water. This temporal pattern is coherent with the summer Arctic Dipole index that was higher in 2008 and 2011. Our results suggest that the Arctic Dipole might influence the export of river water from the Laptev Sea. Moreover, the river water inventory in the Laptev Sea seems related to the freshwater content of the Arctic Ocean with a 2 years lag.
Elevated dissolved organic carbon biodegradability from thawing and collapsing permafrost
Authors: Abbott Benjamin W. , Larouche Julia R. , Jones Jeremy B. , Bowden William B. , Balser Andrew W. 
Published: September 2014

AbstractAs high latitudes warm, a portion of the large organic carbon pool stored in permafrost will become available for transport to aquatic ecosystems as dissolved organic carbon (DOC). If permafrost DOC is biodegradable, much will be mineralized to the atmosphere in freshwater systems before reaching the ocean, accelerating carbon transfer from permafrost to the atmosphere, whereas if recalcitrant, it will reach marine ecosystems where it may persist over long time periods. We measured biodegradable DOC (BDOC) in water flowing from collapsing permafrost (thermokarst) on the North Slope of Alaska and tested the role of DOC chemical composition and nutrient concentration in determining biodegradability. DOC from collapsing permafrost was some of the most biodegradable reported in natural systems. However, elevated BDOC only persisted during active permafrost degradation, with a return to predisturbance levels once thermokarst features stabilized. Biodegradability was correlated with background nutrient concentration, but nutrient addition did not increase overall BDOC, suggesting that chemical composition may be a more important control on DOC processing. Despite its high biodegradability, permafrost DOC showed evidence of substantial previous microbial processing, and we present four hypotheses explaining this incongruity. Because thermokarst features form preferentially on river banks and lake shores and can remain active for decades, thermokarst may be the dominant short‐term mechanism delivering sediment, nutrients, and biodegradable organic matter to aquatic systems as the Arctic warms.
Neutrino Astrophysics
Authors: Haxton Wick C. 
Published: September 2014

AbstractThe article contains sections titled:IntroductionSolar NeutrinosThe Standard Solar ModelSNOand Super‐KamiokandeNeutrino Mass and OscillationsSolar Neutrinos: OutlookAtmospheric NeutrinosThe Neutrino SourceAtmospheric Neutrinos and Proton‐Decay DetectorsOutlookSupernovae Neutrinos and NucleosynthesisThe Explosion Mechanism and Neutrino BurstSupernova Neutrino PhysicsNeutrinos and NucleosynthesisNeutrinos in Big‐Bang Nucleosynthesis (BBN)The Neutrino ProcessThe r‐ProcessNeutrino Cooling and Red GiantsRed Giants and Helium IgnitionNeutrino Magnetic MomentsHigh‐Energy Astrophysical NeutrinosNeutrino Production by Cosmic RaysPoint Sources and Neutrino TelescopesAcknowledgments
Rhodium‐Catalyzed Direct Oxidative CH Acylation of 2‐Arylpyridines with Terminal Alkynes: A Synthesis of Pyrido[2,1‐a]isoindoles
Authors: Zhao Binlin , Yu Mengxuan , Liu Hui , Chen Yu , Yuan Yu , Xie Xuejian 
Published: September 2014

AbstractA synthesis of pyrido[2,1‐a]isoindoles is reported by the rhodium‐catalyzed direct oxidative CH acylation of 2‐aryl pyridines with terminal alkynes. The desired products were obtained in moderate to excellent yields. This is an efficient and clean method to construct CC/CN bonds in one step. In addition, the effective rhodium(III) catalyst was isolated and characterized by X‐ray crystallography.magnified image
Bioproduction of Chiral Epoxyalkanes using Styrene Monooxygenase from Rhodococcus sp. ST‐10 (RhSMO)
Authors: Toda Hiroshi , Imae Ryouta , Itoh Nobuya 
Published: September 2014

AbstractWe describe the enantioselective epoxidation of straight‐chain aliphatic alkenes using a biocatalytic system containing styrene monooxygenase from Rhodococcus sp. ST‐10 and alcohol dehydrogenase from Leifsonia sp. S749. The biocatalyzed enantiomeric epoxidation of 1‐hexene to (S)‐1,2‐epoxyhexane (>44.6 mM) using 2‐propanol as the hydrogen donor was achieved under optimized conditions. The biocatalyst had broad substrate specificity for various aliphatic alkenes, including terminal, internal, unfunctionalized, and di‐ and tri‐substituted alkenes. Here, we demonstrate that this biocatalytic system is suitable for the efficient production of enantioenriched (S)‐epoxyalkanes.magnified image
Palladium‐Catalyzed Suzuki Carbonylative Reaction of α‐Halomethyl Oxime Ethers: A Regioselective Route to Unsymmetrical 1,3‐Oxyiminoketones
Authors: Noverges Bárbara , Medio‐Simón Mercedes , Asensio Gregorio 
Published: September 2014

AbstractThe three‐component reaction of α‐halomethyl oxime ethers, boronic acids and carbon monoxide at atmospheric pressure catalyzed by tetrakis(triphenylphosphine)palladium(0) gives efficiently unsymmetrical β‐alkoxyimino carbonyl compounds with total control of the regioselectivity, in high yield and atomic economy. Simple commercially available starting materials are used in this synthetic procedure. The three components assembly takes place preferentially versus the competing direct coupling or other possible side reactions. The mechanism of the transformation was investigated by NMR and intermediate palladium(II) complexes were detected.magnified image
Efficient Copper Catalyzed CN Coupling Reaction in Water by Using 2‐Hydroxybenzohydrazides as Ligands
Authors: Yan Nan‐Nan , Wu Feng‐Tian , Zhang Jie , Wei Qian‐Bing , Liu Ping , Xie Jian‐Wei , Dai Bin 
Published: September 2014

AbstractAn efficient and environmentally friendly protocol has been developed for CuSO4‐catalyzed N‐arylation of nitrogen‐containing nucleophiles with aryl halides in water. The method uses 2‐hydroxybenzohydrazides as ligand, avoids the use of organic solvents, and tolerates functional groups well.
Zusammenrücken und Stapeln: von atmenden Poren zu dreidimensionaler ionischer Selbstorganisation unter elektrochemischer Kontrolle
Authors: Cui Kang , Mali Kunal S. , Ivasenko Oleksandr , Wu Dongqing , Feng Xinliang , Walter Michael , Müllen Klaus , De Feyter Steven , Mertens Stijn F. L. 
Published: September 2014

AbstractWir zeigen mithilfe der Rastertunnelmikroskopie den spontanen und reversiblen Übergang zwischen zwei‐ und dreidimensionaler Selbstorganisation eines supramolekularen Systems an der Grenzfläche zwischen Flüssigkeit und Metalloberfläche unter elektrochemischer Kontrolle. Durch Abstimmen des Grenzflächenpotentials können wir unsere Zielmoleküle selektiv zu einem Muster aus offenen Poren organisieren und diese mit Gastmolekülen füllen oder aber in einer Doppellage stapeln. Mithilfe eines einfachen elektrostatischen Modells können wir erklären, welche Ladungsdichte zur Bildung von Doppellagen und im Gegenzug welches Molekülgröße/Ladungs‐Verhältnis zum Design neuer Bausteine nötig ist. Unsere Befunde können zu einer neuen Klasse elektrochemisch kontrollierter dynamischer Wirt‐Gast‐Systeme, künstlicher Rezeptoren und “intelligenter” Materialien führen.
Recognition of Nucleic Acid Junctions Using Triptycene‐Based Molecules
Authors: Barros Stephanie A. , Chenoweth David M. 
Published: September 2014

AbstractThe modulation of nucleic acids by small molecules is an essential process across the kingdoms of life. Targeting nucleic acids with small molecules represents a significant challenge at the forefront of chemical biology. Nucleic acid junctions are ubiquitous structural motifs in nature and in designed materials. Herein, we describe a new class of structure‐specific nucleic acid junction stabilizers based on a triptycene scaffold. Triptycenes provide significant stabilization of DNA and RNA three‐way junctions, providing a new scaffold for the development of nucleic acid junction binders with enhanced recognition properties. Additionally, we report cytotoxicity and cell uptake data in two human ovarian carcinoma cell lines.
Gold(I)‐Catalyzed Highly Diastereo‐ and Enantioselective Alkyne Oxidation/Cyclopropanation of 1,6‐Enynes
Authors: Qian Deyun , Hu Haoxiang , Liu Feng , Tang Bin , Ye Weimin , Wang Yidong , Zhang Junliang 
Published: September 2014

AbstractA highly enantioselective oxidative cyclopropanation of 1,6‐enynes catalyzed by cationic AuI/chiral phophoramidite complexes is presented. The new method provides convenient access to densely functionalized bicyclo[3.1.0]hexanes bearing three contiguous quaternary and tertiary stereogenic centers with high enantioselectivity (up to e.r. 98:2). Control experiments suggest that the quinoline moiety of the β‐gold vinyloxyquinolinium intermediate in the reaction plays an important role in promoting good enantioselectivity through a transitional auxiliary effect in the transition state.
Squeezing, Then Stacking: From Breathing Pores to Three‐Dimensional Ionic Self‐Assembly under Electrochemical Control
Authors: Cui Kang , Mali Kunal S. , Ivasenko Oleksandr , Wu Dongqing , Feng Xinliang , Walter Michael , Müllen Klaus , De Feyter Steven , Mertens Stijn F. L. 
Published: September 2014

AbstractWe demonstrate the spontaneous and reversible transition between the two‐ and three‐dimensional self‐assembly of a supramolecular system at the solid–liquid interface under electrochemical conditions, using in situ scanning tunneling microscopy. By tuning the interfacial potential, we can selectively organize our target molecules in an open porous pattern, fill these pores to form an auto‐host–guest structure, or stack the building blocks in a stratified bilayer. Using a simple electrostatic model, we rationalize which charge density is required to enable bilayer formation, and conversely, which molecular size/charge ratio is necessary in the design of new building blocks. Our results may lead to a new class of electrochemically controlled dynamic host–guest systems, artificial receptors, and smart materials.