bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical phosphorylation improves the moisture resistance of soy flour‐based wood adhesive
Authors: Zhu Dan , Damodaran Srinivasan 
Published: January 2014

ABSTRACTA green‐chemistry approach to improve the moisture resistance of soy flour (SF)‐based wood adhesive is described. Chemical phosphorylation of SF (PSF), using POCl3 as the phosphorylating agent, dramatically increased its wet bond strength. The optimum POCl3:SF ratio that produced maximum wet bond strength was about 0.15 (g g−1). The increase in wet bond strength of PSF (PSF0.15) was mostly due to the phosphate groups incorporated into the proteins and carbohydrates, and to a lesser degree to phosphorylation‐induced protein denaturation. The attached phosphate groups acted as cross‐linking agents, either via covalent esterification with hydroxyl groups on wood chips or via ionic and hydrogen‐bonding interactions with functional groups in wood chips. At hot‐press temperatures above 160°C the wet bond strength of PSF0.15 was >2.6 MPa, a level that might be acceptable for interior‐used hardwood plywood and particleboard. POCl3 is a low cost, general‐purpose reagent and therefore PSF‐based adhesive is expected to be environmentally friendly. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40451.
Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides
Authors: Dai Ran , Wilson Daniel J. , Geders Todd W. , Aldrich Courtney C. , Finzel Barry C. 
Published: January 2014

Abstract7,8‐Diaminopelargonic acid synthase (BioA) of Mycobacterium tuberculosis is a recently validated target for therapeutic intervention in the treatment of tuberculosis (TB). Using biophysical fragment screening and structural characterization of compounds, we have identified a potent aryl hydrazine inhibitor of BioA that reversibly modifies the pyridoxal‐5′‐phosphate (PLP) cofactor, forming a stable quinonoid. Analogous hydrazides also form covalent adducts that can be observed crystallographically but are incapable of inactivating the enzyme. In the X‐ray crystal structures, small molecules induce unexpected conformational remodeling in the substrate binding site. We compared these conformational changes to those induced upon binding of the substrate (7‐keto‐8‐aminopelargonic acid), and characterized the inhibition kinetics and the X‐ray crystal structures of BioA with the hydrazine compound and analogues to unveil the mechanism of this reversible covalent modification.
Prevalence of aspirin resistance in Asian‐Indian patients with stable coronary artery disease
Authors: Chadha D.S. , Sumana Budha , Karthikeyan Ganesan , Jayaprasad V. , Arun Shet S. 
Published: January 2014

ObjectiveTo evaluate the prevalence of pharmacological resistance to aspirin therapy by measuring platelet functions using the technique of light transmission aggregometry.BackgroundAspirin is the cornerstone of antiplatelet therapy in patients with coronary artery disease (CAD). However, a substantial proportion of patients manifest breakthrough thrombotic events despite regular intake of aspirin suggesting therapeutic resistance to aspirin.MethodsWe prospectively studied 126 patients with stable coronary artery disease at a tertiary center, who were recruited after ensuring compliance with a single formulation of aspirin (enteric coated aspirin 150 mg). Platelet aggregation was measured using light transmission aggregometry with ADP (10 µM) and Arachidonic acid (0.5 mg/mL). Pharmacological aspirin resistance was defined as the combined demonstration of mean platelet aggregation of ≥70% with 10 µM ADP and a mean aggregation of ≥20% with 0.5 mg/mL A.A. Patients satisfying either one of the above criteria were defined as semi‐responders. Patients satisfying neither criterion were defined as “aspirin responders”.ResultsOut of 126 patients with stable CAD, 64 % were responders, 36% were non responders (semi‐responders = 34% and resistant = 2%). Of the laboratory parameters, only the total leukocyte count was significantly associated with the presence of aspirin resistance (P < 0.03).ConclusionPharmacological resistance to aspirin is noted in 36% (semi‐responders = 34% and resistant = 2%) of Asian Indian patients with stable CAD. Long‐term follow up of these patients will assist in determining the clinical importance of this phenomenon. © 2014 Wiley Periodicals, Inc.
ChemInform Abstract: LiMn2O4 Nanoparticles Anchored on Graphene Nanosheets as High‐Performance Cathode Material for Lithium‐Ion Batteries.
Authors: Lin Binghui , Yin Qing , Hu Hengrun , Lu Fujia , Xia Hui 
Published: January 2014

AbstractNanocrystalline LiMn2O4/graphene nanosheet (GNS) composite is hydrothermally prepared by dispersing GNS in H2O followed by addition of KMnO4 and LiOH (autoclave, 180 °C, 5 h).
ChemInform Abstract: High‐Pressure Synthesis and Characterization of Li2Ca3[N2]3 — An Uncommon Metallic Diazenide with [N2]2‐ Ions.
Authors: Schnick Wolfgang , et al. et al. 
Published: January 2014

AbstractLi2Ca3[N2]3 is synthesized from a stoichiometric mixture of LiN3 and Ca(N3)2 in a multianvil device (9 GPa, 1023 K, 20 min).
ChemInform Abstract: Synthesis and Characterization of Novel Polyoxometalates with an Inverted‐Keggin Structure as a New Class of Building Unit.
Authors: Ueda Tadaharu , Machida Kazuki , Shiro Motoo , Kaneno Daisuke 
Published: January 2014

Abstract(NPr4)4 (Pr‐PO3)4Mo12O36 (I), (NPr4)4(HOOC‐ (CH2)2‐PO3) 4Mo12O36 (II), and (NBu4)4 (H2C=CH‐PO3)4Mo12O36 (III) are precipitated at room temperature from H2O/MeCN molybdate solutions, the corresponding tetraalkylammonium bromide, and propylphosphonic acid, 2‐carboxyethylphosphonic acid, and vinylphosphonic acid, respectively.
ChemInform Abstract: Pd17In4Se4, a Metal‐Rich Palladium—Indium Selenide with an Open‐Framework Structure.
Authors: Zakharova Elena Yu. , Churakov Andrei V. , Doert Thomas , Kuznetsov Alexey N. 
Published: January 2014

AbstractNeedle‐like crystals of the new title compound are synthesized from a mixture of the elements in a ratio of Pd:In:Se = 7:2:1 (silica ampule, 750 °C, 7—10 d).
ChemInform Abstract: Alkoxybromination of Olefins Using Ammonium Bromide and Oxone.
Authors: Kumar Macharla Arun , Naresh Mameda , Rohitha Chozhiyath Nappunni , Narender Nama 
Published: January 2014

AbstractA mild, efficient, highly regio‐ and stereoselective method for the alkoxybromination of various olefins is given.
ChemInform Abstract: Electrophilic α‐Oxygenation Reaction of β‐Ketoesters Using N‐Hydroxycarbamates: Control of the Ambident Reactivity of Nitrosoformate Intermediates.
Authors: Frazier Charles P. , Sandoval David , Palmer Leoni I. , de Alaniz Javier Read 
Published: January 2014

AbstractA high O‐selectivity is observed in this nitrosocarbonyl aldol reaction.
ChemInform Abstract: Environmetally Benign Michael and Claisen Schmidt Reaction of Aromatic Carbonyl Compounds by Alkaline Polyionic Resin.
Authors: Jaitak Vikas , Kaul V. K. , Das Pralay 
Published: January 2014

AbstractAn alkaline, polystyrene‐supported ammonium salt is successfully applied as catalyst in regioselective Michael and Claisen—Schmidt reactions.
ChemInform Abstract: Highly Atom‐Efficient and Chemoselective Reduction of Ketones in the Presence of Aldehydes Using Heterogeneous Catalysts.
Authors: Takahashi Yusuke , Mitsudome Takato , Mizugaki Tomoo , Jitsukawa Koichiro , Kaneda Kiyotomi 
Published: January 2014

AbstractThe presented approach is also applicable to a column reactor, leading to a gram‐scale synthesis.
ChemInform Abstract: Synthesis of 2‐Bromo‐1‐aryl‐1H‐indenes via a Ag(I) Promoted Domino 2π‐Electrocyclic Ring‐Opening/4π‐Electrocyclization Reaction of 1,2‐Diaryl Substituted gem‐Dibromocyclopropanes.
Authors: Rosocha Gregory , Batey Robert A. 
Published: January 2014

AbstractA domino reaction sequence yields indenes both from symmetric gem‐dibromocyclopropanes (I) and (IV), and unsymmetrical gem‐dibromocyclopropanes (VII), via a silver(I)‐promoted ionization and 2π‐disrotatory electrocyclic ring‐opening, followed by a 4π‐conrotatory electrocyclic ring‐closing reaction of the allylic carbocation intermediate.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Fluorooxylation of Styrenes.
Authors: Yuan Zheliang , Peng Haihui , Liu Guosheng 
Published: January 2014

AbstractPd‐Catalyzed reaction of (Z)‐configured hydroxyethyl styrenes (I) with NFSI results in the formation of 1‐aryl‐2‐fluorotetrahydrofurans with low trans selectivity.
ChemInform Abstract: Syntheses and Crystal Structures of 2,7‐Di(trimethylsilyl)thieno[3,2‐e]benzothiophene, 1,2,5,6(5)‐Tetra(trimethylsilyl)‐1,2,5,6 (2,3)‐tetrathiophenacyclooctaphan‐3(z),7(z)‐diene, and 2,7‐Di(trimethylsilyl)thieno[3,2‐e]benzothiophene‐4‐ol.
Authors: Wang Zhihua , Shi Jianwu , Tian Xinyong , Xu Li , Li Chunli , Wang Hua 
Published: January 2014

AbstractMcMurry reaction of dicarbaldehyde (III) efficiently affords the thienobenzothiophene (IV) along with two unexpected compounds (V) and (VI).
ChemInform Abstract: 1,2,3‐Triazoles as Versatile Directing Group for Selective sp2 and sp3 C—H Activation: Cyclization vs. Substitution.
Authors: Ye Xiaohan , He Zhengrong , Ahmed Tonia , Weise Keith , Akhmedov Novruz G. , Petersen Jeffrey L. , Shi Xiaodong 
Published: January 2014

AbstractThe choice of the substitution pattern of the triazole‐containing directing group determines whether a substitution or cyclization takes place.
ChemInform Abstract: Synthesis of 3‐(Diarylmethylene)oxindoles via a Palladium‐Catalyzed One‐Pot Reaction: Sonogashira—Heck—Suzuki—Miyaura Combined Reaction.
Authors: Dong Guang Ri , Park Sunhwa , Lee Dahye , Shin Kye Jung , Seo Jae Hong 
Published: January 2014

AbstractA Pd‐catalyzed cascade reaction consisting of an intramolecular Heck‐type cyclization and subsequent Suzuki—Miyaura coupling is achieved under typical Sonogashira reaction conditions to yield diarylmethylene indolones (IV).
ChemInform Abstract: Coumarins: Facile and Expeditious Synthesis via Keggin‐Type Heteropolycompounds under Solvent‐Free Condition.
Authors: Rafiee Ezzat , Fakhri Akram , Joshaghani Mohammad 
Published: January 2014

AbstractRapid procedures for the synthesis of structurally diverse coumarin derivatives via Pechmann reactions of acetoacetates with mono‐ or polyphenols are described using supported heteropoly‐compounds as catalyst.
ChemInform Abstract: Highly Stereoselective Transformation of (1S,3S)‐cis‐1,3‐Disubstituted Tetrahydro‐β‐carbolines into (1S,3R)‐trans‐1,3‐Disubstituted Tetrahydro‐β‐carbolines: An Improved Asymmetric Synthesis of Tadalafil from L‐Tryptophan.
Authors: Dong Jing , Meng Tian‐Zhuo , Shi Xiao‐Xin , Zou Wen‐Hui , Lu Xia 
Published: January 2014

AbstractBy applying this method the synthesis of compound (VI) is realized which can be used as precursor for the synthesis of tadalafil.
ChemInform Abstract: Post Ugi Gold(I)‐ and Platinum(II)‐Catalyzed Alkyne Activation: Synthesis of Diversely Substituted Fused Azepinones and Pyridones.
Authors: Kumar Amit , Vachhani Dipak D. , Modha Sachin G. , Sharma Sunil K. , Parmar Virinder S. , Van der Eycken Erik V. 
Published: January 2014

AbstractThe Ugi four‐component reaction of 2‐pyrrole aldehydes and analogous indole and benzothiophene aldehydes with primary amines, isonitriles, and alkynoic acids offers the expected adducts (V), (XI), and (XIV) which can be readily used for the synthesis of various fused pyridones and azepinones.
ChemInform Abstract: Total Synthesis and Structural Revision of Incargutines A and B.
Authors: Kinbara Atsushi , Yamagishi Takehiro , Ouchi Hiroki , Miyaoka Hiroaki 
Published: January 2014

AbstractThe total synthesis of the proposed structures (Ia) and (IIa) of Incargutines A and B reveals significant differences in their spectral properties compared to the natural products.
ChemInform Abstract: Propagative Exfoliation of High Quality Graphene.
Authors: Feng Lan , Liu Yue‐Wen , Tang Xing‐Yan , Piao Yanmei , Chen Shu‐Fen , Deng Shun‐Liu , Xie Su‐Yuan , Wang YuHuang , Zheng Lan‐Sun 
Published: January 2014

AbstractHigh quality graphene sheets are prepared via exfoliation of graphite by repeated (8 cycles) reductive, propagative alkylation in Li and naphthalene containing THF to which 1‐bromododecane (6‐bromohexanoic acid, 11‐bromoundecanoic acid, or methyl‐6‐bromohexanoate) is slowly added (reaction time of 12 h).
A comparison of three methods to regenerate activated carbon saturated by diesel fuels
Authors: Han Xue , Wishart Erin , Zheng Ying 
Published: January 2014

AbstractThe three regeneration methods (thermal treatment, ultrasonication, and solvent extraction) were studied to regenerate the adsorptive capacity of the activated carbons (ACs) that were saturated by the nitrogen and sulphur containing compounds of diesel fuels. This is one of the few reports that give attention to the regeneration of heteroaromatic compounds contaminated ACs. Both model diesel and light cycled oil (LCO) were served as feedstocks. High regeneration rates can be obtained for all three approaches when model diesel was used as the feed. As model diesel was replaced by LCO, a significant drop in capacity restoration can be observed for the first few cycles and then the decrease rate slowed down. Solvent extraction outperformed the other two methods. The causes to lower regeneration performance were also analysed. It is shown that the regenerated carbons had a lower porosity and surface area and fewer surface oxygen functional groups than fresh carbon regardless of the regeneration methods employed. Significant micropore blockage was observed in the carbon regenerated by the thermal approach due to the coke deposit under thermal conditions. Mesopores formed during the regeneration by ultrasonication are considered to promote the carbon adsorption capacity.
Dependence of the Efficiency Improvement of Black‐Dye‐Based Dye‐Sensitized Solar Cells on Alkyl Chain Length of Quaternary Ammonium Cations in Electrolyte Solutions
Authors: Ozawa Hironobu , Okuyama Yu , Arakawa Hironori 
Published: January 2014

AbstractDependence of the suppression of the backward electron transfer reaction from the TiO2 photoelectrode to I3− in the electrolyte on the alkyl chain length of the quaternary ammonium cation has been investigated for further efficiency improvement of high‐performance cosensitized dye‐sensitized solar cells (DSCs). The tetraheptylammonium cation was found to be more effective than the tetraethylammonium and tetrabutylammonium cations for the suppression of the backward electron transfer reaction without changing the conduction band energy of TiO2. 12.0 % conversion efficiency, which is the second highest efficiency for DSCs based on ruthenium sensitizers, was achieved in the cosensitized DSC with Black dye and D131 by using an electrolyte solution containing a moderate concentration of tetraheptylammonium iodide.
Synthesis of H2V3O8/Reduced Graphene Oxide Composite as a Promising Cathode Material for Lithium‐Ion Batteries
Authors: Zhu Kai , Yan Xiao , Zhang Yongquan , Wang Yuhui , Su Anyu , Bie Xiaofei , Zhang Dong , Du Fei , Wang Chunzhong , Chen Gang , Wei Yingjin 
Published: January 2014

AbstractH2V3O8 nanowires wrapped by reduced graphene oxide (RGO) are synthesized successfully through a simple hydrothermal process. The structural properties of the samples are characterized by X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, Raman scattering, and X‐ray photoelectron spectroscopy. The RGO nanosheets modify the surfaces of the H2V3O8 nanowires through VC linkages. The H2V3O8/RGO composite exhibits a remarkably enhanced electrochemical performance in terms of its reversible capacity, cyclic performance, and rate capability. The material shows high discharge capacities of 256 and 117 mA h g−1 at the current densities of 0.1 and 1 A g−1, respectively, with almost no capacity fading after fifty charge/discharge cycles. Cyclic voltammetry and electrochemical impedance spectroscopy show that the superior electrochemical performance of H2V3O8/RGO can be attributed to the cooperation of RGO, which provides better mechanical flexibility, higher electronic conductivity, and smaller charge‐transfer resistance.
Plasmacytoid dendritic cells license regulatory T cells, upon iNKT‐cell stimulation, to prevent autoimmune diabetes
Authors: Beaudoin Lucie , Diana Julien , Ghazarian Liana , Simoni Yannick , Boitard Christian , Lehuen Agnès 
Published: January 2014

Invariant NKT (iNKT)‐cell stimulation with exogenous specific ligands prevents the development of type 1 diabetes (T1D) in NOD mice. Studies based on anti‐islet T‐cell transfer showed that iNKT cells prevent the differentiation of these T cells into effector T cells in the pancreatic lymph nodes (PLNs). We hypothesize that this defective priming could be explained by the ability of iNKT cells to induce tolerogenic dendritic cells (DCs) in the PLNs. We evaluated the effect of iNKT‐cell stimulation on T1D development by transferring naïve diabetogenic BDC2.5 T cells into proinsulin 2−/− NOD mice treated with a long‐lasting α‐galactosylceramide regimen. In this context, iNKT cells induce the conversion of BDC2.5 T cells into Foxp3+ Treg cells in the PLNs accumulating in the pancreatic islets. Furthermore, tolerogenic plasmacytoid DCs (pDCs) characterized by low MHC class II molecule expression and TGF‐β production are critical in the PLNs for the recruitment of Treg cells into the pancreatic islets by inducing CXCR3 expression. Accordingly, pDC depletion in α‐galactosylceramide‐treated proinsulin 2−/− NOD mice abrogates the protection against T1D. These findings reveal that upon repetitive iNKT‐cell stimulation, pDCs are critical for the recruitment of Treg cells in the pancreatic islets and the prevention of T1D development.
A comparison of the herbicide tolerances of rare and common plants in an agricultural landscape
Authors: Egan J. Franklin , Graham Ian M. , Mortensen David A. 
Published: January 2014

Abstract

Declining plant biodiversity in agroecosystems has often been attributed to escalating use of chemical herbicides, but other changes in farming systems, including the clearing of seminatural habitat fragments, confound the influence of herbicides. The present study introduces a new approach to evaluate the impacts of herbicide pollution on plant communities at landscape or regional scales. If herbicides are in fact a key factor shaping agricultural plant diversity, one would expect to see the signal of past herbicide impacts in the current plant community composition of an intensively farmed region, with common, successful species more tolerant to widely used herbicides than rare or declining species. Data from an extensive field survey of plant diversity in Lancaster County, Pennsylvania, USA, were compared with herbicide bioassay experiments in a greenhouse to test the hypothesis that common species possess higher herbicide tolerances than rare species. Five congeneric pairs of rare and common species were treated with 3 commonly used herbicide modes of action in bioassay experiments, and few significant differences were found in the tolerances of rare species relative to common species. These preliminary results suggest that other factors beyond herbicide exposure may be more important in shaping the distribution and abundance of plant species diversity across an agricultural landscape. Environ Toxicol Chem 2014;33:696–702. © 2014 SETAC
High‐Resolution 1H Solid‐State NMR Spectroscopy Using Windowed LG4 Homonuclear Dipolar Decoupling
Authors: Halse Meghan E. , Schlagnitweit Judith , Emsley Lyndon 
Published: January 2014

AbstractWe investigate the optimal implementation of windowed LG4 decoupling for the direct acquisition of high‐resolution 1H solid‐state NMR spectra in the moderate magic‐angle spinning regime (ωr<2π × 35 kHz). We determine how the optimal value of the azimuth of the LG rotation axis, α, is affected by the choice of windowing parameters. We find that for both the windowless and windowed implementation of LG4, the optimal value of α is that for which the chemical‐shift scaling factor is approximately 0.43. We then provide an analytical expression for estimating the chemical‐shift scaling factor as a function of both α and the windowed decoupling parameters, which allows the optimal value of α to be easily determined for any implementation of LG4. We also introduce a simple and general method for improving the performance of any phase‐modulated homonuclear dipolar decoupling sequence by compensating for pulse imperfection errors that accumulate in windowed spectra due to the repeated switching of the RF irradiation. This method involves the introduction of short (<0.5 µs) compensation pulses at the start and end of each decoupling pulse, the duration and phase of which are chosen to cancel the effects of the amplitude and phase transients that arise as a result of the RF switching. We demonstrate how this method can be implemented for homonuclear dipolar decoupling sequences such as wPMLG and wLG4 to reduce the chemical‐shift scaling factor distortions generated by phase transients such that high‐quality, high‐resolution 1H NMR spectra can be acquired at arbitrary RF offsets.
Assessing the challenges of Fourier transform infrared spectroscopic analysis of blood serum
Authors: Hughes Caryn , Brown Michael , Clemens Graeme , Henderson Alex , Monjardez Geraldine , Clarke Noel W. , Gardner Peter 
Published: January 2014

AbstractThere are many approaches to measuring the infrared spectrum of a blood serum sample. Naturally, each approach will have both advantages and disadvantages. We report on the progress of the application of infrared spectroscopy in the field of blood serum analysis towards clinical application, with a focus on prostate cancer. In order to perform a high‐powered study with clinical relevance, choosing the most suitable approach must undergo careful consideration. We review the possibilities of using different sample preparation methods and speculate upon the potential pitfalls of both transmission and attenuated total reflectance (ATR) techniques. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A tool to measure shared clinical understanding following handoffs to help evaluate handoff quality
Authors: Bates Katherine E. , Bird Geoffrey L. , Shea Judy A. , Apkon Michael , Shaddy Robert E. , Metlay Joshua P. 
Published: January 2014

BACKGROUNDInformation exchanged during handoffs contributes importantly to a team's shared mental model. There is no established instrument to measure shared clinical understanding as a marker of handoff quality.OBJECTIVETo study the reliability, validity, and feasibility of the pediatric cardiology Patient Knowledge Assessment Tool (PKAT), a novel instrument designed to measure shared clinical understanding for pediatric cardiac intensive care unit patients.DESIGNTo estimate reliability, 10 providers watched 9 videotaped simulated handoffs and then completed a PKAT for each scenario. To estimate construct validity, we studied 90 handoffs in situ by having 4 providers caring for an individual patient each complete a PKAT following handoff. Construct validity was assessed by testing the effects of provider preparation and patient complexity on agreement levels.SETTINGA 24‐bed pediatric cardiac intensive care unit in a freestanding children's hospital.RESULTSVideo simulation results demonstrated score reliability. Average inter‐rater agreement by item ranged from 0.71 to 1.00. During in situ testing, agreement by item ranged from 0.41 to 0.87 (median 0.77). Construct validity for some items was supported by lower agreement rates for patients with increased length of stay and increased complexity.DISCUSSIONResults suggest that the PKAT has high inter‐rater reliability and can detect differences in understanding between handoff senders and receivers for routine and complex patients. Additionally, the PKAT is feasible for use in a real‐time clinical environment. The PKAT or similar instruments could be used to study effects of handoff improvement efforts in inpatient settings. Journal of Hospital Medicine 2014;9:142–147. © 2014 Society of Hospital Medicine