bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pre-treatment MRI-based radiomics approach combinedwith clinical characteristics for predicting early recurrence in hepatocellular carcinoma after radiofrequency ablation treatment
Authors: Li Tianran 
Published: June 2024

Abstract

Purpose To develop a prediction model combining MRI-based radiomic features with clinical indicators in predicting early recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) treatment.
Materials and Methods In total, 169 HCC patients who underwent MRI before RFA treatment from January 2015 to December 2021 were retrospectively enrolled at our institution. Patients were randomly divided into training cohorts (n=135) and test cohorts (n= 34). In the training cohorts, feature selection was performed by variance threshold, select K-best, and least absolute shrinkage and selection operator (LASSO).Then three machine-learning classifiers [support vector machine (SVM), logistic regression (LR), and random forest (RF)] were applied to build predictive models using radiomics or integrated radiomics-clinical characteristics. The models were tested in training cohorts and test cohorts according to the early recurrence of HCC by the receiver operating characteristic curve (ROC) analysis.
Results Alpha fetoprotein levels, platelet count, and the location of HCC were effective clinical indicators for predicting early recurrence of HCC after treatment with RFA. Progressive reduction of MRI radiomics features by dimension screening identified 16 effective features. The predictive models based on radiomics-only showed good performance across all classifiers constructed by SVM, LR, and RF (SVM, train: AUC 0.957 [0.920-0.993], test: AUC 0.826 [0.677-0.925]; LR, train: AUC 0.956 [0.924-0.987], test: AUC 0.830[0.674-0.986]; RF, train: AUC 0.945 [0.909-0.982], test: AUC 0.826 [0.682-0.969]). The radiomics-clinical integrated predictive models (clinical, routine MRI image features, and radiomics parameters) showed better performance by SVM, LR, and RF classifiers (SVM, train: AUC 0.956 [0.921-0.992], test: AUC 0.830 [0.686-0.973]; LR, train: AUC 0.957 [0.926-0.988], test: AUC 0.830[0.673-0.986]; RF, train: AUC 0.975 [0.952-0.997], test: AUC 0.909 [0.807-1.000]), in which the RF classifier performed best (0.909 vs 0.830 vs 0.830, P＜0.05) .
Conclusion The MRI radiomics-clinical integrated predictive models effectively predicted early recurrence in HCC patients treated with RFA, and the RF classifier may be the most effective model.
The Effects of an Anti-inflammatory Diet Alone or in Combination with Acupuncture on Mental Health, Anthropometric Indices, and Metabolic Status in Diabetic Patients with Depression: A Randomized, Controlled Clinical Trial
Authors: Namazi Nazli , Irandoost Pardis , Firouzjaei Amir , Heshmati Javad , Sadeghi Erfan , Ayati Mohammad Hossein 
Published: June 2024

Abstract

Background
The present clinical trial examined the efficacy of an anti-inflammatory diet combined with acupuncture to an anti-inflammatory diet alone and common treatment in depressed patients with type 2 diabetes (T2DM).
Methods
In this randomized controlled clinical trial, 90 patients with T2DM suffering from mild to moderate depression were included. They were randomly allocated to one of 3 groups: (i) acupuncture and anti-inflammatory diet, (ii) anti-inflammatory diet alone, and (iii) standard treatment, and followed for 8 weeks. Two sessions/week of acupuncture therapy were considered for the combination therapy group. Mental health (depression, anxiety), biochemical parameters, dietary intake, and anthropometric indices were measured at baseline and the end of the trial.
Results
Of 90 diabetic patients, 83 subjects completed the intervention. Acupuncture therapy with diet decreased depression and anxiety by 20% (p < 0.05 for both) at the end of the trial. The combination therapy decreased WC (p = 0.04) HbA1C (p = 0.008), and increased high-density lipoprotein cholesterol (HDL-C) concentrations (p = 0.02) compared to diet alone.
Conclusion
Our findings showed that acupuncture along with an anti-inflammatory diet can be more effective in improving mental health, HbA1C, and abdominal obesity compared to an anti-inflammatory diet alone in diabetic patients with mild to moderate depression after 8 weeks. However, more clinical trials with larger sample sizes and longer duration are recommended to confirm the efficacy of this adjuvant therapy.
Roux-en-Y Gastric Bypass restores insulin and gut hormones responses to acute exercise
Authors: Roschel Hamilton , Gil Saulo , Murai Igor , Dantas Wagner , Merege-Filho Carlos Alberto , Leitão Alice , Nicoletti Carolina , Lima Alisson , Benatti Fabiana , de Cleva Roberto , Santo Marco , Kirwan John , Gualano Bruno 
Published: June 2024

Abstract

Background
The acute exercise-mediated changes in metabolic, immunomodulatory, and gut hormones are blunted by excessive adiposity. We investigated whether bariatric surgery restore the acute responses to exercise on glucose metabolism, gut hormones, and inflammatory markers in women with severe obesity.
Methods
Thirteen women eligible for bariatric surgery underwent an acute exercise session before and 3 months after surgery. Blood samples were collected at baseline and immediately and 30 minutes after exercise to analyze glucose, insulin, inflammatory markers (INFγ, IL-1β, IL-1ra, TNFα, MCP1, IL-6, IL-8, IL-17A, IL-4, and IL-10), and gut hormones (Ghrelin, GIP, GLP-1, PP, PYY).
Results
Before surgery, there were no significant changes in post-exercise glucose response (all P > 0.05). Post-surgery, glucose levels decreased immediately and 30 minutes after exercise (both P < 0.05), but glucose AUC remained similar (181.0 vs. 166.8 mg/dL x min− 1, P > 0.05) between conditions. Insulin response to exercise remained unchanged regardless of surgery (all P > 0.05), but insulin AUC was significantly reduced post-surgery (60.7 vs. 26.3 µU/mL x min− 1, P = 0.046). No changes occurred in GLP-1 and PYY levels pre-surgery exercise (all P > 0.05); however, both parameters were increased immediately and 30 minutes post-exercise (all P < 0.05) after the surgical intervention. AUC for GLP-1 (2.3 vs. 14.5 pg/mL x min− 1, P = 0.008) and PYY (9.9 vs. 224.2 pg/mL x min− 1, P = 0.0004) were increased post-surgery. Surgery did not affect PP or GIP responses to exercise. Both parameters were elevated immediately (before surgery: P = 0.027 and P = 0.002, respectively; after surgery: P = 0.096 and P = 0.002, respectively) and 30 minutes post-exercise (before surgery: P = 0.002 and P < 0.0001, respectively; after surgery: P = 0.0004 and P = 0.054, respectively), regardless of surgery. PP AUC was lower post- (549.6 vs. 261.7 pg/mL x min− 1, P = 0.046) vs. pre-surgery. No changes were observed for ghrelin levels and inflammatory markers (all P > 0.05).
Conclusion
Bariatric surgery improves the gut hormone responses to exercise in parallel with enhanced peripheral insulin response.
Mechanism and prediction of residual stress generation in ultrasonic vibration-assisted grinding of bearing steel
Authors: Zhang Zhihui , Luan Zhenmeng , Zhao Man , Mao Jian , Liu Gang , Zhang Liqiang , Feng Yixuan , Yang Bo , Liang Steven Y. 
Published: June 2024

Abstract

The surface residual stress of the parts has an important influence on their performance. The generation mechanism of surface residual stress in ultrasonic vibration-assisted grinding (UVAG) of bearing steel was investigated, and the correlation between processing parameters and residual stresses was obtained. Based on the ultrasonic vibration-assisted grinding force and thermal model and the flow stress model considering the initial material microstructure, the mechanical and thermal stresses of the material were calculated. Finally, the theoretical model of residual stress is established based on the yield theory and experimentally verified. High-speed ultrasonic aerostatic spindle for ultrasonic vibration-assisted grinding, change the inlet pressure to realize the ultrasonic amplitude and frequency adjustment, the experimental results show that the cutting direction and the vertical cutting direction of the residual stress test results and the model prediction results of the average relative error of 11.4% and 11.7%, and the rule of change is more consistent. Based on the experimental results, the influence pattern of process parameters on the experimental results was analyzed. The results show that the residual compressive stress on the surface of ultrasonic vibration-assisted grinding is directly proportional to the grinding depth, feed rate, and inlet pressure of pneumatic ultrasonic wave, and inversely proportional to the linear speed of the grinding wheel. This study provides a theoretical basis for the analysis of UVAG residual stress and optimization of UVAG process parameters.
Mediating Effects of Coping Strategies Between Activation for Self-Management of Back Pain and Work Engagement: A Cross-Sectional Study of Cardiac Catheterization Laboratory Nurses
Authors: She Liping , Wang Jinju , Wu Yafeng , li Shaoman , Zhou Juanjuan , Zheng Xuemei 
Published: June 2024

Abstract

Background
Work engagement is a critical factor in improving the quality of care, nurses' job satisfaction, and hospital profitability. However, nurses, especially those in cardiac catheterization labs, face significant physical demands such as lower back pain from prolonged use of lead personal protective equipment, impacting their work engagement. To examine the back pain self-management activation, work engagement, and role of coping strategies among nurses in the cardiac catheterization laboratory.
Methods
This was a cross-sectional study design. A convenience sampling recruited 296 participants from 18 hospitals in Jiangsu and Anhui provinces of China from February to March 2023. The Demographics questionnaire, Participant Activation for Management of Back Pain Questionnaire, Simplified Coping Skill Questionnaire, and the Utrecht Work Engagement Scale were used to survey participants. A Pearson correlation analysis was conducted to determine the relationship between positive self-management of back pain, coping strategy, and work engagement. Bootstrap method was used to analyze the mediating effect of coping strategies.
Results
Work engagement and back pain self-management activation among cardiac catheterization laboratory nurses were moderate and influenced by various sociodemographic factors. Activation for self-management of back pain directly impacted work engagement, partially mediated by positive coping strategies, which accounted for 25.96% of the total effect.
Conclusion
Activation of self-management of back pain and positive coping strategies promote work engagement among cardiac catheterization laboratory nurses. Nursing managers should integrate individual and organizational interventions to increase nurses' self-management activation and work engagement.
Analysis of root reinforcement for several typical plant roots in Jixian, Shanxi based on asymptotic homogenization theory.
Authors: khan Inam , Lushuang Gao , jinkun Huang , khan Faiza 
Published: June 2024

Abstract

This study examines the effect of root systems on the stability of loess slopes in Ji County, Shanxi, by utilizing theoretical analysis, numerical simulation, and experiments. Centering on the material properties of roots and soil, characteristic conditions, and soil parameters, the research tests Pinus tabulaeformis, Robinia pseudoacacia, and Platycladus orientalis. Asymptotic homogenization theory is employed to determine the material parameters of the root-soil composite and to investigate the impacts of different root morphologies on mechanical properties. Numerical simulations of slope behavior under different boundary conditions evaluate the effect on comparable plastic strain. The findings highlight the stabilizing impact of root systems on slopes, approved by triaxial tests on the root-soil composite, which confirm the exactness of the proposed hypothesis. The study underscores the advantages of the homogenization model, such as simplicity and efficiency, and emphasizes the significance of reasonable boundary conditions in large-scale slope simulations. Symmetric boundary conditions are especially suitable for these simulations. Vegetation roots improve the stress field of shallow slope soil, making shear stress more uniform and enhancing slope stability. The small error between the theoretical model and test results illustrates the model's precision, offering valuable insights into the part of vegetation roots in improving slope stability.
Genetic determination of piglet survival upon PRRSV outbreaks
Authors: Font Joaquim Tarres , Jové-Juncà Teodor , Hernández-Banqué Carles , González-Rodríguez Olga , Ganges Llilianne , Gol Sofia , Díaz Marta , Reixach Josep , Pena Romi , Quintanilla Raquel , Ballester Maria 
Published: June 2024

Abstract

Breeding animals to produce more robust and disease-resistant pig populations becomes a complementary strategy to the more conventional methods of biosecurity and vaccination. The objective of this study was to explore the ability of a panel of genetic markers and immunity parameters to predict the survival rates during a natural PRRSV outbreak. Ten-week-old female Duroc pigs (n = 129), obtained from 61 sows and 20 boars, were naturally infected with a highly pathogenic PRRSV genotype 1 strain. Prior to infection, piglets were screened for immunity parameters (IgG levels in plasma and SOX13 mRNA expression in blood) and genetic markers previously associated to PRRSV immune response and immunity traits. Additionally, the 20 boars were genotyped with a panel of 132 single nucleotide polymorphisms (SNPs). Survival analysis showed that mortality was significantly higher for animals with low basal IgG levels in plasma and/or high SOX13 mRNA expression in blood. The genotypes of sires for SNPs associated with IgG plasma levels, CRP in serum, percentage of γδ T cells, lymphocyte phagocytic capacity, total number of lymphocytes and leukocytes, and MCV and MCH were significantly associated with the number of surviving offspring. Furthermore, CD163 and GBP5 markers were also associated to piglet survival. The effects of these SNPs were polygenic and cumulative, survival decreased from 94–21% as more susceptible alleles were accumulated for the different markers. Our results confirmed the existence of genetic variability in survival after PRRSV infection and provided a set of genetic markers and immunity traits associated with PRRS resistance.
Evaluation and comparison of autologous particulate dentin with demineralized freeze dried bone allograft in ridge preservation procedures – A prospective clinical study
Authors: Beldhi Manisha , Penmetsa Gautami S , Gottumukkala Sruthima NVS , KSV Ramesh , P Mohan kumar , Manchala Bhavya 
Published: June 2024

Abstract

Objectives
To compare the effectiveness of Autologous Particulate Dentin (APD) with Demineralized Freeze-Dried Bone Allograft (DFDBA) in ridge preservation, using radiographic and clinical parameters.
Materials and Methods
Thirty subjects with the indication of mandibular posterior teeth extraction were randomly assigned to either a test or control group. After atraumatic extraction, ridge preservation was performed using APD mixed with i-PRF in the test group and DFDBA mixed with i-PRF in the control group. Both groups had sockets sealed with an A-PRF membrane. Clinical parameters (plaque index, gingival index, healing index) and radiographic parameters (vertical ridge height, horizontal ridge width) were assessed at baseline and 6 months using CBCT.
Results
The test group exhibited a lesser reduction in ridge dimensions compared to the DFDBA group (p < 0.001). Both groups showed a significant decrease in ridge dimensions from baseline to 6 months (p < 0.001). There was no statistical difference in clinical parameters (plaque index, gingival index, healing index) between the groups at 6 months (p > 0.001).
Conclusions
APD grafts resulted in significant improvements in radiographic parameters, specifically in vertical ridge height and horizontal ridge width, compared to the DFDBA group.
Clinical Relevance
Autologous particulate dentin is a promising, versatile substitute for regenerative procedures. While more research on its long-term efficacy and application is needed, current evidence suggests it could significantly improve patient care and outcomes.
Factors affecting healthcare workers burnout and their conceptual models: a scoping review
Authors: Nagle Evija , Griskevica Inguna , Rajevska Olga , Ivanovs Andrejs , Mihailova Sandra , Skruzkalne Iluta 
Published: June 2024

Abstract

Background
The occupational stress that contributes to the development of burnout syndrome remains one of the greatest scientific challenges. Despite years of research into burnout and its determinants, burnout continues to attract the attention of researchers, and healthcare workers (HCWs) continue to experience burnout in large numbers. Burnout has a significant impact on both the mental and physical well-being of HCWs and reduces patient-centered healthcare. This review aims to identify the factors affecting healthcare workers’ burnout (FAHCWB) and their conceptual models.
Methods
The review was conducted according to Arksey and O'Malley's framework using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Searches were conducted in PubMed, Scopus, Wiley, ProQuest, Sage, Science Direct, and EBSCO using the following keywords: healthcare professionals, burnout, and internal/external factors. Empirical, qualitative, quantitative, and mixed-design research articles published in English with full-text access in peer-reviewed journals that investigated the FAHCWB were included. For an in-depth analysis of the included articles, the authors developed a data synthesis table, and thematic analysis was applied to the analysis.
Results

According to the inclusion criteria, 38 articles were selected
for further data analysis. Six main themes were identified: (1)
FAHCWB; (2) conceptual models of FAHCWB; (3) research tools for
studying FAHCWB; (4) findings on FAHCWB in the context of different
models; (5) differences between findings from different models; (6)
what is known and not known about FAHCWB. The results of the review
show that most researchers conduct research on factors affecting
burnout (FAB) based on factors related to the work environment,
with fewer studies based on individual factors, including
personality factors. Most of the research is based on the
model developed by Maslach et al. The Maslach Burnout Inventory
(MBI) has been used in most studies.

Conclusions
Despite years of research, burnout continues to evolve rapidly, indicating that scientific research needs to be re-focused. Research should be conducted using different conceptual models and new research tools that allow the syndrome to be studied from a multidimensional perspective, including both the work environment and individual factors.
The peripancreatic microbiota is associated with the severity of acute pancreatitis
Authors: Guo Xiaolan , Xu Yao , Li Kaiwei , Zhang Jingzhu , Tong Zhihui , Li Weiqin , Hong Donghuang 
Published: June 2024

Abstract

Background
Infectious pancreatic necrosis (IPN) is associated with the prognosis of acute pancreatitis (AP). The correlation between the microbial diversity in the peripancreatic region and the severity of AP remains unclear. The objectives of this study were to analyse the microbial composition of peripancreatic necrosis in IPN patients by 16S ribosomal RNA (16S rRNA) and internal transcribed spacer (ITS) sequencing.
Methods
Patients with acute pancreatitis who met the clinical diagnostic criteria for IPN were prospectively included. These patients were subsequently divided into a sepsis group and a non-sepsis group. Samples of peripancreatic necrotic fluid were collected by percutaneous puncture drainage, followed by 16S rRNA sequencing and internal transcribed spacer (ITS) sequencing.
Results
There was no significant difference between the sepsis and non-sepsis groups in terms of bacterial alpha diversity, and there was a significant difference in beta diversity according to the Welch's t test (P < 0.001), Adonis analysis (P = 0.037) and Anosim analysis (P = 0.032). The relative abundance of Klebsiella differed significantly between the two groups (2.79% vs. 34.14%, P = 0.0093) and correlated with the length of hospital stay (r = 0.422, P = 0.025).
Conclusion
The peripancreatic microbiota is associated with the severity of acute pancreatitis, with Klebsiella being the dominant microflora in patients with IPN combined with sepsis.
Innovative Nomogram Approach to Enhance the Prediction of Helicobacter pylori Infection in Children via Magnetic-Controlled Capsule Endoscopy
Authors: Wang Ling , Lin Kai , Cheng Weiwei , Wang Xing , Zhang Yong , Feng Yuling , Gu Zhujun , Liu Haifeng 
Published: June 2024

Abstract

Background
Early detection and intervention are crucial in managing Helicobacter pylori (HP) infections, which are associated with various gastrointestinal diseases in children. The traditional Kyoto gastritis scoring system, though effective, requires adaptation for non-invasive techniques like magnetic-controlled capsule endoscopy to enhance early diagnosis and improve patient comfort.
Methods
This retrospective study involved 474 pediatric patients who underwent magnetic-controlled capsule endoscopy coupled with a 13C urea breath test at the Children’s Hospital affiliated with Shanghai Jiao Tong University School of Medicine from January to December 2023. Utilizing the Kyoto gastritis scoring system, adapted for magnetic-controlled capsule endoscopy, we evaluated its effectiveness in diagnosing HP infection. To enhance diagnostic precision, a nomogram was developed that integrates these gastritis scores with demographic and clinical variables, providing a comprehensive tool for assessing the risk of HP infection.
Results
Our findings indicate that a Kyoto gastritis score of ≥ 2 has a high predictive accuracy for HP infection, with an area under the curve (AUC) of 0.755 (95% CI: 0.697–0.813). The study highlighted Kyoto gastritis score and white mucous as significant predictors of infection, with odds ratios of 5.94(95% CI: 3.40-10.49) and 2.78 (95% CI: 1.65–4.71), respectively. A predictive model incorporating these factors alongside demographic and clinical variables demonstrated robust diagnostic potential. The nomogram, incorporating these factors, showed robust diagnostic potential and improved the predictive accuracy.
Conclusions
The adapted Kyoto gastritis scoring system for magnetic-controlled capsule endoscopy offers a promising approach for the early detection of HP infection in children. By integrating multiple diagnostic indicators from non-invasive magnetic-controlled capsule endoscopy, this model enhances early diagnostic accuracy and can significantly reduce discomfort and risks associated with traditional endoscopic procedures.