bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical impact of restless legs syndrome in patients with migraine: a 12-year, single-center, longitudinal study
Authors: Suzuki Keisuke , Suzuki Shiho , Haruyama Yasuo , Fujita Hiroaki , Hirata Koichi 
Published: August 2024

AbstractAlthough many studies have indicated a significant association between migraine and restless legs syndrome (RLS), few long-term longitudinal studies have examined RLS in patients with migraine. We conducted a single-center, 12-year, longitudinal study of migraine patients and assessed whether RLS was present in 2010, 2017, or 2022 to evaluate its associations with clinical factors. Headache-related disability was assessed using the Migraine Disability Assessment (MIDAS). Sleep quality, daytime sleepiness, and depressive symptoms were assessed using the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS) and the Beck Depression Inventory-II (BDI-II), respectively. Of the 262 patients included at baseline (2010), 101 were available after 7 years (2017), and 74 were available after 12 years (2022). The RLS incidence rates were 13.7%, 20.8%, and 24.3% in 2010, 2017, and 2022, respectively. The RLS severity score did not significantly differ among the three time points. The persistent RLS group, defined as those who were positive for RLS at the last evaluation in addition to the first and/or second evaluations, had significantly higher MIDAS, BDI-II, PSQI and ESS scores than did the never RLS group, defined as those who did not exhibit RLS at any of the three time points. Our 12-year longitudinal study revealed significant impacts of RLS on the burden of patients with migraine.
The China trade shock and the gender wage gap in India: A district-level analysis
Authors: Saha Kajari 
Published: August 2024

AbstractThis study provides new evidence on the debate surrounding international trade and the gender wage gap in a developing country context. It asks whether increased competition from trade has any causal effect on the district-level gender wage gap in India. Changes in competition from trade are measured using changes in imports from China, owing to the dramatic rise in Chinese imports into India in recent years. To isolate the supply-driven component of Chinese imports and establish causality, I use Chinese import growth in other low and lower-middle-income countries as an instrument for Chinese import growth in India. Results indicate a positive and statistically significant impact of an increase in Chinese imports on the gender wage gap over time. In addition to the economy-wide sample of workers, this effect holds true for the sub-samples of casual laborers and rural sector workers where the majority of women workers in India are concentrated. Unlike previous studies using industry-level data, the district-level focus of this study allows us to capture micro-level effects, as well as the net effects of trade in the surrounding district.
Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells
Authors: Liu Jian-Yu , Jiang Yao-Yao , Li Peng-Jie , Yao Bo , Song Yi-Jing , Gao Ji-Xiu , Said Gulab , Gao Yang , Lai Jun-Yu , Shao Chang-Lun 
Published: August 2024

AbstractAs one of the common malignancies that threaten human life, bladder cancer occurs frequently with a high mortality rate in the world, due to its invasion, recurrence and drug resistance. Natural products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities, especially in the area of cancer. Brefeldin A (BFA) is a natural Arf-GEFs inhibitor, but due to the low aqueous solubility, strong toxicity, and poor bioavailability, it is urgent to conduct structural optimization research. Herein, a new BFA pyridine acrylate derivative CHNQD-01281 with improved solubility was prepared and found to exert moderate to strong antiproliferative activity on a variety of human cancer cell lines. It was noteworthy that CHNQD-01281 was most sensitive to two bladder cancer cell lines T24 and J82 (IC50 = 0.079 and 0.081 μmol/L) with high selectivity index (SI = 14.68 and 14.32), suggesting a superior safety to BFA. In vivo studies revealed that CHNQD-01281 remarkably suppressed tumor growth in a T24 nude mice xenograft model (TGI = 52.63%) and prolonged the survival time (ILS = 68.16%) in an MB49 allogeneic mouse model via inducing infiltration of cytotoxic T cells. Further mechanism exploration indicated that CHNQD-01281 regulated both EGFR/PI3K/AKT and EGFR/ERK pathways and mediated the chemotactic effect of chemokines on immune effector cells. Overall, CHNQD-01281 may serve as a potential therapeutic agent for bladder cancer through multiple mechanisms.
Materials selection and fashion design: strengthening reflections on fibre’s nature in fibres and textiles selection
Authors: Mazzitelli Melissa , Papile Flavia , Del Curto Barbara 
Published: August 2024

AbstractTextile ecosystems are complex productive realities, in the eye of the cyclone when it comes sustainability-related analysis. Being characterised by very complex value-chains and interconnection of productive actors, textiles production and use represent one of the most crucial challenges for the circular and sustainable transition. Their deployment is esteemed to be in growing for the next years, therefore reflections on how to improve product and materials circularity in this sector is of increasing interest in research and industrial practice. In this contribution, authors will try to map the material properties that can influence textiles application in the fashion sector, focusing on the coupling of material selection activity and application of design strategies to anticipate at best the reflections upon textiles use and recirculation. Results of this activity are then shown and discussed to question the applicability of the reported data into a fashion design activity, to promote awareness and critical reflections upon materials use while designing new fashion goods.
An Effective Tag Estimation Method Based upon Artificial Neural Networks and Signal Strength for Anticollision in Radio Frequency Identification Systems
Authors: Alhuthali Shakir A. H. , Murad Mohsin , Tasadduq Imran A. , Awedh Mohammad Hamza , Rushdi Ali M. , Alotaibi Sultan 
Published: August 2024

AbstractRadio frequency identification (RFID) technology has been widely used in applications such as access control, inventory management, spatial positioning, and object identification. Accurate tag estimation is one of the major challenges in RFID reader systems particularly in areas where large tag populations are to be identified such as shopping carts, warehouse inventory monitoring, and small ruminant farms. This paper proposes a new tag estimation technique employing artificial neural networks (ANNs) and signal strength to read large tag populations. The technique estimates the number of tags through the signal strength of the backscatter channel for efficient implementation of dynamic framed slotted Aloha (DFSA) protocol by analyzing the RN16 and the received signal strength indicator (RSSI). The ANN model is trained using the signal strength of various tag populations and can identify the number of tags with minimal errors. The proposed technique does not require any modification in the tags and is implemented as a minimal software script to be added to the tag estimation module of the reader. The proposed signal strength-ANN model is able to estimate the accurate number of tags thereby improving the performance of the employed DFSA model.
Deciphering the Socio-Ecological Determinants of Contemporary Collective Action in China: Insights from 2010–2016 Panel Data Analysis
Authors: Ma Yiwen , Chen Hao 
Published: August 2024

AbstractThe current study delves into the macro-level driving forces behind collective action in contemporary China, advancing beyond the constraints of previous narrower perspectives by adopting an all-encompassing socio-ecological and cultural approach. Utilizing the CASM-China database and analyzing 2454 socio-ecological indicators, we scrutinize the incidence of conventional, disruptive, and violent collective actions, alongside 11 manually coded triggers. Furthermore, employing panel data spanning from 2010 to 2016 enhances the robustness of our predictor selection, while a principal component analysis reveals a four–factor structure. Significantly, the Modernization dimension (factor 1) predicts both conventional and violent collective actions, correlating with issues such as “education” and “homeowner/property”. The Secondary and Tertiary Industries dimension (factor 2) forecasts disruptive collective action, associated with “pension/welfare” problems. In contrast, the Primary Industry dimension (factor 3) shows a negative correlation with violent and disruptive collective actions, particularly affecting “medical dispute” issues. The Living Condition dimension (factor 4) positively correlates with conventional collective action with various social issues. These findings deepen our comprehension of the intricate interplay between socio-cultural and ecological factors and collective action in China, offering new pathways for future research.
Vicarious vs experiential information in the consumer’s construal level on imported food safety risk perception
Authors: Choi Jae Chul 
Published: August 2024

AbstractConsumers acquire information about the imported food safety risks through distal channels such as the Internet versus proximal channels such as direct experience, and these channels influence the consumer perception of safety. However, the empirical analysis of the sources of information (distal–proximal) channels is second to none. This article explores whether direct experience with imported food induces different levels of safety risks compared to distal information through social media. Based on the Construal Level Theory (CLT), the study examines consumer responses in a survey involving 500 respondents out of 1000 distributed in South Korea, using high-level construal (vicarious information) versus a low-level construal (direct experience) framework to assess food safety risk perception. We narrowed the imported food from China to South Korea to obtain a robust analysis. Our analysis shows that vicarious (distal) sources of information increase perceived food safety risks in the minds of the consumer, while direct experience (proximity) decreases food safety risks. In a supplementary analysis, those respondents who had visited China exhibited lower levels of food safety risk of the imported food. We infer that the lower-level construal (experience) mediates the effects of higher-level construal (indirect, social media) on the imported food safety risk. However, the correlation is nonlinear, explaining why some studies find proximity while others find distance in correlation with the food safety risk. In a contribution to the literature, this study answers a longstanding question regarding international business in food supplies, supports the CLT framework, and offers a policy recommendation for both Korea and China to enhance their information channels to counteract misinformation.
An evaluation of the use of plastic waste in the manufacture of plastic bricks
Authors: Rauniyar Abishek , Nakrani Rinkal Kishor , Narpala Saketh Reddy , Nehaun  , Arun Sija 
Published: August 2024

AbstractAn integrated analysis is performed for the present study, including an evaluation of the mechanical and durability properties of plastic brick, a cost-effectiveness analysis, and an eco-benefit analysis of recycling plastic waste into bricks. To promote sustainable construction practices, pp waste is used in plastic brick to replace waste material often discarded in landfills and burned. This study involved the preparation of 36 (230 mm × 110 mm × 90 mm) bricks. Modified fly ash containing 40, and 45% of the cement weight was incorporated into the samples. There is an increase in waste production among the Indian population. Some of these wastes pose a threat to the environment. There is also a significant amount of plastic waste in the country. Even though it is not biodegradable, it poisons trees and aquatic organisms. Thus, waste plastics were repurposed for use in the construction industry. Cement, fly ash, M sand, and plastic waste fibers are used to make plastic bricks. Polypropylene (PP) has a high deformation capacity and is a cost-effective material. Plastic waste is used in this study in the form of polypropylene fibers. To produce the bricks, different mix ratios were used in which PP waste was used in proportions of 5%, 10%, and 15% (represented as Mix1, Mix2, and Mix3), based on the total mixing of the polycarbonate substance volume of bricks. The purpose of this study is to investigate the feasibility of utilizing plastic wastes to produce a cost-effective and lightweight plastic brick for use in construction. Compressive strength, water absorption, soundness, efflorescence, and hardness tests were carried out on the bricks. The compressive strength of mix 2 at a load of 426 kg is the highest of the three plastic bricks tested. A comparison of this proportion with other mix proportions and conventional brick effectiveness.
Barriers and enablers to engagement with a type 2 diabetes remission project in the North East of England: qualitative perspectives of patients
Authors: Boocock Ruth C. , Haste Anna , Moore Helen J. , Lake Amelia A. 
Published: August 2024

Abstract
This qualitative research sought to identify factors influencing patient choice of, and patient-related internal and external enablers and barriers to engagement with, type 2 diabetes (T2D) remission strategies offered by the Remission in diabetes (REMI.D) project. Patients had a choice of three diets: Total Diet Replacement (TDR)-Formula Food Products, TDR-Food, and Healthy lifestyle approach; and three activity pathways: Everyday life, General Practitioner referral, and Social hub. Semi-structured interviews were recorded and transcribed. Thematic analysis used the Framework Method and NVivo 12 to assist with generation and organisation of codes, inductive and deductive (Theoretical Domains Framework). The REMI.D project was a place-based approach (place in this case being defined as two local authorities with significant rates of deprivation) situated in the North East of England. Twenty patients out of a possible 65 patients took part. Areas of interest included: patient choice, patient intention, patient adherence, patient non-adherence, and patient stigma. Addition of a more moderate dietary strategy (not dissimilar to the diet in the Healthier You NHS Diabetes Prevention Programme) to the existing NHS England T2D Path to Remission programme may enable more patients to achieve remission or delayed progression with deprescribing of diabetes medications. Embedding a tailored physical activity path within or as a bolt-on to the NHS programme requires consideration. Limited resources should be targeted towards patients who identify with more barriers or fewer opportunities for health behaviour modification. Further research on use of virtual programmes in deprived areas is warranted.
Quality of couple relationship and associated factors in parents of NICU-cared infants during the first year after birth
Authors: Persson Christine , Ericson Jenny , Eriksson Mats , Salari Raziye , Flacking Renée 
Published: August 2024

Abstract
Objective
To describe factors associated with quality of couple relationships among parents of infants cared for in neonatal intensive care units (NICUs) 1 year after birth and examine the trajectory of the relationship quality compared to parents from maternity units (MUs).

Study design
Longitudinally comparative cohort design. Parents answered surveys during the first year after discharge about the couple relationship, social support, and depressive symptoms.

Results
Better social support and a hospital stay of 7–14 days were positively associated with the couple relationship in NICU mothers, whereas not having slept together with the partner and infant during hospitalization were negatively associated. Depressive symptoms were negatively associated with the relationship among NICU fathers. There were no differences in trajectory of the relationship quality between NICU and MU parents.

Conclusion
To strengthen couple relationships, it could be important to improve social support, facilitate space and time for support, and enable togetherness during hospitalization.
Translucency and colour masking ability of hybrid CAD/CAM materials with different thicknesses: in vitro study
Authors: Tolba Zeinab Omar , Hassanien Eman Ezzat Youssef 
Published: August 2024

Abstract
Objective
To evaluate effect of material thickness and translucency of two different hybrid CAD/CAM materials on their masking ability.

Materials and Methods
40 rectangular-shaped specimens (12 × 14 mm) were obtained from Vita Enamic and Grandio blocks at 0.5 and 1 mm-thick (n = 10/group). Colour parameters of specimens were measured on PMMA tooth-coloured replica backgrounds (A2, C4) and black, white backings using dental spectrophotometer. Translucency parameter (TP) and masking ability (∆E00) values of tested materials with 0.5, and 1 mm thicknesses were calculated. Quantitative variables were compared between groups using student t-test.

Results
TP and ∆E00 significantly decreased as thickness of tested materials increased. Grandio showed significantly higher TP values. There were significantly lower ΔE00 values for Vita Enamic compared to Grandio at 1 mm thickness and inversely insignificant at 0.5 mm. The 0.5 mm-thick ∆E00 of tested materials was above clinical acceptability threshold, whereas, 1 mm-thick did not exceed showing better masking properties.

Conclusions
Thickness is more effective for colour masking than translucency. In thin thickness, the masking ability is less effective, irrespective of tested materials. Translucency of tested materials was affected by their composition. Both hybrid CAD/CAM materials are promising alternatives for masking dark discolouration at 1 mm-thick.
A national survey of the impact of the COVID-19 pandemic on training and wellbeing of restorative and mono-speciality specialist trainees in the UK and Ireland
Authors: Mylonas Petros , Spicer Olivia , Chin Jann Siew 
Published: August 2024

AbstractIntroduction COVID-19 emergency and associated measures across the UK and Ireland during the first and third waves of the pandemic disrupted mainstream dental services and training across all specialties.Aims Investigate the effect of COVID-19 pandemic on training, mental health and wellbeing of specialty trainees (STs) in restorative dentistry and associated mono-specialities across the United Kingdom and Ireland.Materials and methods A cross-sectional survey was conducted exploring experiences of STs in restorative dentistry, prosthodontics, endodontics and periodontics (n = 101) across the United Kingdom and Ireland during the first (March 2020) and third (July 2021) waves of the pandemic. Results were analysed quantitatively and qualitatively.Results In total, 28 postgraduate trainees responded, yielding a 28% response rate. STs reported perceived impact on their training in March 2020 and July 2021, with some redeployed to urgent dental care duties in this time period. STs reported reduction in speciality-level clinical activities and a negative impact on mental health and wellbeing in both March 2020 and July 2021. A total of 12 STs felt COVID-19 negatively impacted their future careers.Conclusion The COVID-19 pandemic negatively impacted clinical training and mental health of STs in restorative dentistry and associated mono-specialities across the United Kingdom and Ireland. Increased flexibility and accounting for lost clinical activities could have improved ST morale and wellbeing.
Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1
Authors: Sui Ying , Shen Ziyang , Li Xiaoyou , Lu Ya , Feng SiTong , Ma Rong , Wu Jianzhong , Jing Changwen , Wang Zhuo , Feng Jifeng , Cao Haixia 
Published: August 2024

AbstractThe obstacle to effectively treating Diffuse Large B-cell Lymphoma (DLBCL) lies in the resistance observed toward standard therapies. Identifying therapeutic targets that prove effective for relapsed or refractory patients poses a significant challenge. OTUD3, a deubiquitinase enzyme, is overexpressed in DLBCL tissues. However, its role in DLBCL has not been investigated. Our study has brought to light the multifaceted impact of OTUD3 in DLBCL. Not only does it enhance cell survival through the deubiquitination of MYL12A, but it also induces CD8+ T cell exhaustion within the local environment by deubiquitinating PD-L1. Our findings indicate that the OTUD3 inhibitor, Rupatadine, exerts its influence through competitive binding with OTUD3. This operation diminishes the deubiquitination of both MYL12A and PD-L1 by OTUD3. This research unveils the central and oncogenic role of OTUD3 in DLBCL and highlights the potential clinical application value of the OTUD3 inhibitor, Rupatadine. These findings contribute valuable insights into addressing the challenges of resistant DLBCL cases and offer a promising avenue for further clinical exploration.
Preserving a qubit during state-destroying operations on an adjacent qubit at a few micrometers distance
Authors: Motlakunta Sainath , Kotibhaskar Nikhil , Shih Chung-You , Vogliano Anthony , McLaren Darian , Hahn Lewis , Zhu Jingwen , Hablützel Roland , Islam Rajibul 
Published: August 2024

AbstractProtecting qubits from accidental measurements is essential for controlled quantum operations, especially during state-destroying measurements or resets on adjacent qubits, in protocols like quantum error correction. Current methods to preserve atomic qubits against such disturbances waste coherence time, extra qubits, and introduce additional errors. We demonstrate the feasibility of in-situ state-reset and state-measurement of trapped ions, achieving >99.9% fidelity in preserving an ‘asset’ ion-qubit while a neighboring ‘process’ qubit is reset, and >99.6% preservation fidelity while applying a detection beam for 11 μs on the same neighbor at a distance of 6 μm. This is achieved through precise wavefront control of addressing optical beams and using a single ion as both a quantum sensor for optical aberrations and an intensity probe with >50 dB dynamic range. Our demonstrations advance quantum processors, enhancing speed and capabilities for tasks like quantum simulations of dissipation and measurement-driven phases, and implementing error correction.
Multiple temperatures and melting of a colloidal active crystal
Authors: Massana-Cid Helena , Maggi Claudio , Gnan Nicoletta , Frangipane Giacomo , Di Leonardo Roberto 
Published: August 2024

AbstractThermal fluctuations constantly excite all relaxation modes in an equilibrium crystal. As the temperature rises, these fluctuations promote the formation of defects and eventually melting. In active solids, the self-propulsion of “atomic” units provides an additional source of non-equilibrium fluctuations whose effect on the melting scenario is still largely unexplored. Here we show that when a colloidal crystal is activated by a bath of swimming bacteria, solvent temperature and active temperature cooperate to define dynamic and thermodynamic properties. Our system consists of repulsive paramagnetic particles confined in two dimensions and immersed in a bath of light-driven E. coli. The relative balance between fluctuations and interactions can be adjusted in two ways: by changing the strength of the magnetic field and by tuning activity with light. When the persistence time of active fluctuations is short, a single effective temperature controls both the amplitudes of relaxation modes and the melting transition. For more persistent active noise, energy equipartition is broken and multiple temperatures emerge, whereas melting occurs before the Lindemann parameter reaches its equilibrium critical value. We show that this phenomenology is fully confirmed by numerical simulations and framed within a minimal model of a single active particle in a periodic potential.