bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary Incontinence Care-Seeking Barriers Among Latina Patients: What Are We Missing?
Authors: Pancheshnikov Anna , Harrington Bryna J. , Handa Victoria L. , Yanes Liz I. , Le Neveu Margot , Voegtline Kristin M. , Olson Sarah B. , Blomquist Joan L. , Jacobs Stephanie , Patterson Danielle , Chen Chi Chiung Grace 
Published: July 2024

Importance
The Latina population is the largest growing ethnic group in the United States with high levels of health disparities in urinary incontinence (UI) treatment and complications rates, which may be due to disproportionately high barriers to UI care-seeking among Latinas.

Objectives
The objectives of this study were to compare barriers to UI care-seeking among Latina, non-Latina Black, and non-Latina White patients by utilizing the Barriers to Incontinence Care Seeking Questionnaire (BICS-Q) total scores, and to compare specific barriers utilizing BICS-Q subscales.

Study Design
In this cross-sectional study, patients accessing primary care were recruited to complete the BICS-Q, International Consultation on Incontinence Questionnaire–Short Form, and Prolapse and Incontinence Knowledge Questionnaire–Urinary Incontinence. The BICS-Q total and subscale scores were compared among ethnic/racial groups.

Results
A total of 298 patients were included in the study with 83 Black, 144 Latina, and 71 White participants per self-identified ethnicity/race. The total BICS-Q score was highest for Latina participants, followed by White and Black participants (11.2 vs 8.2 vs 4.9, respectively, P < 0.0001). Latina participants had significantly higher BICS-Q subscale scores compared with Black participants with no significant differences between Latina and White participants. After controlling for potential confounders, Latina ethnicity/race was still associated with a higher BICS-Q score when compared to Black ethnicity/race (P = 0.0077), and lower Prolapse and Incontinence Knowledge Questionnaire–Urinary Incontinence scores remained independently associated with higher BICS-Q scores (P = 0.0078).

Conclusions
In our study population, Latina patients and patients with lower UI knowledge experience higher barriers to UI care-seeking compared with Black patients and patients with higher UI knowledge. Addressing these barriers may increase care-seeking and improve health equity in the field.
Effects of interfacial debonding on the stability of finitely strained periodic microstructured elastic composites
Authors: Greco Fabrizio , Luciano Raimondo , Pranno Andrea 
Published: July 2024

Predicting failure initiation in nonlinear composite materials, often referred to as metamaterials, is a fundamental challenge in nonlinear solid mechanics. Microstructural failure mechanisms encompass fracture, decohesion, cavitation, compression-induced contact and instabilities, affecting their unconventional static and dynamic performances. To fully take advantage of these materials, especially in extreme applications, it is imperative to predict their nonlinear behaviour using reliable, accurate and computationally efficient numerical methodologies. This study presents an innovative nonlinear homogenization-based theoretical framework for characterizing the failure behaviour of periodic reinforced hyperelastic composites induced by reinforcement/matrix decohesion and interaction between contact mechanisms and microscopic instabilities. Debonding and unilateral contact between different phases are incorporated by employing an enhanced cohesive/contact model, which features a special nonlinear interface constitutive law and an accurate contact formulation within the context of finite strain continuum mechanics. The theoretical formulation is demonstrated using periodically layered composites subjected to macroscopic compressive loading conditions along the lamination direction. Numerical results illustrate the ways in which debonding phenomena, in conjunction with fibre microbuckling, may influence the critical loads of the examined composite solid. The sensitivity of the results obtained through the proposed contact–cohesive model at finite strain with respect to its implementation is also explored.
This article is part of the theme issue ‘Current developments in elastic and acoustic metamaterials science (Part 1)’.
Elastic metasurfaces for Scholte–Stoneley wave control
Authors: Zeighami Farhad , Quqa Said , De Ponti Jacopo Maria , Ayyash Nadeen , Marzani Alessandro , Palermo Antonio 
Published: July 2024

In this work, we investigate the dynamics of Scholte–Stoneley waves (SSWs) travelling along elastic metasurfaces, e.g. thin resonant structures embedding mechanical oscillators, placed at the interface between solid and fluid. To this purpose, an analytical dispersion law, valid in the long-wavelength regime, is derived and used to reveal the hybridization of SSWs with the collective resonance of the mechanical oscillators and the conversion of SSWs into leaky modes within the fluid. The analytical predictions are validated through numerical simulations that include both dispersive and harmonic analysis. Our findings disclose the capabilities of elastic metasurfaces in filtering, trapping and converting SSWs along fluid–solid interfaces, thus supporting the design of novel devices for solid–fluid interaction across various engineering applications, including microfluidics.
This article is part of the theme issue 'Current developments in elastic and acoustic metamaterials science (Part 1)'.
Surface wave mitigation by periodic wave barriers under a moving load: theoretical analysis, numerical simulation and experimental validation
Authors: Ni Yu , Shi Zhifei 
Published: July 2024

Periodic wave barriers (PWB) open a new window for vibration mitigation. However, the Doppler effect is rarely considered in most of the previous investigations on the control of ambient vibration induced by moving loads. This article reveals the significance of the speed and frequency of moving loads on surface waves, and improves the design method of PWB for ambient vibration reduction and isolation. First, the theoretical expression of the main frequency band of surface waves propagating in an elastic half-space caused by a moving load was obtained. Comparisons with the numerical results under three different types of traffic loads were also conducted and good agreement was found. Second, the theoretical expression and numerical results were verified by experimental studies. Some inherent properties of wave propagation caused by a moving load in an elastic half-space were also revealed. Third, two kinds of PWBs, i.e. periodic empty trench barrier and periodic pile barrier, were introduced to mitigate wave propagation. It has been confirmed that if the attenuation zones of PWB match the target frequency bands given by the theoretical expression, good vibration mitigation can be achieved.
This article is part of the theme issue ‘Current developments in elastic and acoustic metamaterials science (Part 1)’.
Elastic wave control in reticulated plates using Schwarz primitive cells
Authors: Hejazi Nooghabi Aida , Thomsen Henrik R. , Zhao Bao , Colombi Andrea 
Published: July 2024

In this work, the Schwarz primitive unit cell is used as the building block of different types of metastructures for steering and focusing elastic vibrations. The emergence of a Bragg-type bandgap when constructing a two-dimensional plate from such unit cells is experimentally validated. It is demonstrated that increasing both mass and porosity of the Schwarz primitive leads to a decrease in the frequency of the out-of-plane propagating wave targeted in this study. By arranging these modified Schwarz primitive unit cells in constant and graded layouts, two-dimensional plates with an embedded metabarrier and a metalens are numerically designed. The metabarrier protects an interior area of the plate from the propagating waves on a wide frequency band (approx. 1.4–3.4 kHz). Equally, the refractive index profile necessary for gradient index lenses is obtained via a progressive variation of the added mass or, alternatively, the porosity of the unit cell over a rectangular area. For the first time, bending of the out-of-plane mode towards the focusing point is practically validated in a challenging mesoscale experiment requiring the assembly of different three-dimensional printed sections of the plate. The increased porosity design is advantageous not only in terms of overall lightweight, but also towards additive manufacturing as it requires less material.
This article is part of the theme issue ‘Current developments in elastic and acoustic metamaterials science (Part 1)’.
Environmental versus litter traits as drivers of microbial decomposer functions
Authors: Stock Svenja C. , Canessa Rafaella , van den Brink Liesbeth , Cavieres Lohengrin A. , Kappler Andreas , Guzmán Carolina Merino , Saldaña Alfredo , Scholten Thomas , Schweiger Andreas H. , Rehfeld Kira , Neidhardt Harald , Oelmann Yvonne , Tielbörger Katja , Bader Maaike Y. , Ehlers Todd A. , Dippold Michaela A. 
Published: July 2024

AbstractPlant litter decomposition is a key ecosystem process with significant implications for global carbon cycling, soil fertility and plant productivity. Given that microbial decomposers are the main players in the decomposition process, it is surprising how little is known about their functional diversity in different habitats or their ability to respond to environmental changes. To fill this knowledge gap, we conducted a litterbag decomposition experiment along a pronounced climate and vegetation gradient in the Chilean Coastal Cordillera (26°S to 38°S), ranging from hyper-arid to temperate, using mixtures of four plant species, native to the respective ecosystems. We analyzed potential decomposition functions of bacterial and fungal litter communities along with their biotic (litter traits) and abiotic (meteorological conditions and soil properties) environments, to determine the relative importance of these environmental factors for microbial community functioning. We also tested the impact of the functional diversity of the decomposer communities (i.e., the diversity of decomposition related functions) on litter mass loss.Functional composition was related most strongly to the temporal variation of precipitation and radiation, explaining about 19 % and 6 % of variation in bacteria and fungi, respectively. In contrast, functional diversity was quite strongly related to litter chemical traits (C:N, C:P, tannins, phenols). Litter mass loss after six months of decomposition was not correlated to the functional diversity of decomposer communities but increased with the presence of habitat generalists likeProteobacteria,Actinobacteria,Firmicutes, andBacteroidetes. Taken together, these results highlight i) the interplay between abiotic factors and chemical litter traits on litter microbial functions and functional diversity and ii) the importance of microbial generalists for litter decomposition across different ecosystems. These results enhance our ability to predict changes in microbial decomposer communities and litter decomposition under future climate-change scenarios.
Computational Screening ofZanthoxylum armatumDC Phytochemicals for inhibiting Mutant P53 in Throat Cancer Therapy
Authors: Taring Ampi , Singpho Senggam Wakhet , Lamu Lobsang , Kalita Bipul Chandra , Tag Hui , Hui Pallabi Kalita 
Published: July 2024

AbstractAimTo investigate the potential of phytochemicals fromZanthoxylum armatumDC in targeting mutant p53 as a therapeutic strategy for throat cancer using an in-silico approach.BackgroundThroat cancer is increasingly associated with mutations in the TP53 gene, leading to dysfunctional p53 proteins. Current synthetic drugs targeting mutant p53 face challenges of toxicity and off-target effects, necessitating the exploration of alternative natural compounds.MethodsWe employed molecular docking, molecular dynamics simulations, MMPBSA analysis, and ADMET studies to identify and characterize effective inhibitors of mutant p53 fromZ. armatumDC phytochemicals.ResultsThree compounds – Z3, Z7, and Z33 – demonstrated superior binding affinities to mutant p53 compared to the commercial drug Prima. These phytochemicals induced more compact and stable protein conformations, with Z3 and Z7 notably restricting active site residual motion. MMPBSA analysis confirmed favourable binding energetics, while ADMET studies indicated drug-like properties with potentially lower toxicity than Prima.ConclusionThis study provides compelling evidence for the potential ofZ. armatumDC phytochemicals, particularly Z3 and Z7, as novel therapeutic agents targeting mutant p53 in throat cancer. These findings offer a foundation for future experimental validation and drug development efforts.
Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer cell lines and isogenic models
Authors: Adams Kristin M. , Wendt Jae-Rim , Wood Josie , Olson Sydney , Moreno Ryan , Jin Zhongmou , Gopalan Srihari , Lang Jessica D. 
Published: July 2024

AbstractOvarian cancers are still largely treated with platinum-based chemotherapy as the standard of care, yet few biomarkers of clinical response have had an impact on clinical decision making as of yet. Two particular challenges faced in mechanistically deciphering platinum responsiveness in ovarian cancer have been the suitability of cell line models for ovarian cancer subtypes and the availability of information on comparatively how sensitive ovarian cancer cell lines are to platinum. We performed one of the most comprehensive profiles to date on 36 ovarian cancer cell lines across over seven subtypes and integrated drug response and multiomic data to improve on our understanding of the best cell line models for platinum responsiveness in ovarian cancer. RNA-seq analysis of the 36 cell lines in a single batch experiment largely conforms with the currently accepted subtyping of ovarian cancers, further supporting other studies that have reclassified cell lines and demonstrate that commonly used cell lines are poor models of high-grade serous ovarian carcinoma. We performed drug dose response assays in the 32 of these cell lines for cisplatin and carboplatin, providing a quantitative database of IC50s for these drugs. Our results demonstrate that cell lines largely fall either well above or below the equivalent dose of the clinical maximally achievable dose (Cmax) of each compound, allowing designation of cell lines as sensitive or resistant. We performed differential expression analysis for high-grade serous ovarian carcinoma cell lines to identify gene expression correlating with platinum-response. Further, we generated two platinum-resistant derivatives each for OVCAR3 and OVCAR4, as well as leveraged clinically-resistant PEO1/PEO4/PEO6 and PEA1/PEA2 isogenic models to perform differential expression analysis for seven total isogenic pairs of platinum resistant cell lines. While gene expression changes overall were heterogeneous and vast, common themes were innate immunity/STAT activation, epithelial to mesenchymal transition and stemness, and platinum influx/efflux regulators. In addition to gene expression analyses, we performed copy number signature analysis and orthogonal measures of homologous recombination deficiency (HRD) scar scores and copy number burden, which is the first report to our knowledge applying field-standard copy number signatures to ovarian cancer cell lines. We also examined markers and functional readouts of stemness that revealed that cell lines are poor models for examination of stemness contributions to platinum resistance, likely pointing to the fact that this is a transient state. Overall this study serves as a resource to determine the best cell lines to utilize for ovarian cancer research on certain subtypes and platinum response studies, as well as sparks new hypotheses for future study in ovarian cancer.
A path analysis disentangling determinants of natal dispersal in a cooperatively breeding bird
Authors: Borger Mirjam J. , Lee Kiran G.L. , Weissing Franz J. , Richardson David S. , Dugdale Hannah L. , Burke Terry , Pen Ido , Komdeur Jan 
Published: July 2024

AbstractDelayed offspring dispersal is an important aspect of the evolution of cooperative breeding. By applying a path-analysis approach to the long-term Seychelles warbler (Acrocephalus sechellensis) dataset, we studied whether and how delayed dispersal is affected by territory quality, the presence of helpers and non-helping subordinates, maternal breeding status, age and fecundity, and offspring sex ratio. We found that offspring are more likely to disperse when their genetic mothers are co-breeders, helpers are absent and territory quality is high. In contrast to earlier findings, our analysis does not support the idea that offspring sex ratio is affected by territory quality and helper presence. Our findings suggest that a complex interplay of ecological and social factors shapes dispersal decisions. Our study underscores the importance of considering proximate factors in understanding cooperative breeding dynamics, and it shows that path analyses offer valuable insights into dissecting the intricate relationships influencing dispersal in wild populations.
Defining Suicidal Thought and Behavior Phenotypes for Genetic Studies
Authors: Monson Eric T. , Colbert Sarah M. C. , Andreassen Ole A. , Ayinde Olatunde O. , Bejan Cosmin A. , Ceja Zuriel , Coon Hilary , DiBlasi Emily , Izotova Anastasia , Kaufman Erin A. , Koromina Maria , Myung Woojae , Nurnberger John I. , Serretti Alessandro , Smoller Jordan W. , Stein Murray B. , Zai Clement C. ,   Suicide Working Group of the Psychiatric Genomics Consortium, Aslan Mihaela , Barr Peter B. , Bigdeli Tim B. , Harvey Philip D. , Kimbrel Nathan A. , Patel Pujan R. ,   Cooperative Studies Program (CSP) #572, Ruderfer Douglas , Docherty Anna R. , Mullins Niamh , Mann J. John 
Published: July 2024

AbstractBackgroundStandardized definitions of suicidality phenotypes, including suicidal ideation (SI), attempt (SA), and death (SD) are a critical step towards improving understanding and comparison of results in suicide research. The complexity of suicidality contributes to heterogeneity in phenotype definitions, impeding evaluation of clinical and genetic risk factors across studies and efforts to combine samples within consortia. Here, we present expert and data-supported recommendations for defining suicidality and control phenotypes to facilitate merging current/legacy samples with definition variability and aid future sample creation.MethodsA subgroup of clinician researchers and experts from the Suicide Workgroup of the Psychiatric Genomics Consortium (PGC) reviewed existing PGC definitions for SI, SA, SD, and control groups and generated preliminary consensus guidelines for instrument-derived and international classification of disease (ICD) data. ICD lists were validated in two independent datasets (N = 9,151 and 12,394).ResultsRecommendations are provided for evaluated instruments for SA and SI, emphasizing selection of lifetime measures phenotype-specific wording. Recommendations are also provided for defining SI and SD from ICD data. As the SA ICD definition is complex, SA code list recommendations were validated against instrument results with sensitivity (range = 15.4% to 80.6%), specificity (range = 67.6% to 97.4%), and positive predictive values (range = 0.59-0.93) reported.ConclusionsBest-practice guidelines are presented for the use of existing information to define SI/SA/SD in consortia research. These proposed definitions are expected to facilitate more homogeneous data aggregation for genetic and multisite studies. Future research should involve refinement, improved generalizability, and validation in diverse populations.
Exploring the Single-Cell Dynamics of FOXM1 Under Cell Cycle Perturbations
Authors: Jawwad Tooba , Kamkaew Maliwan , Phongkitkarun Kriengkrai , Chusorn Porncheera , Sampattavanich Somponnat 
Published: July 2024

ABSTRACTThe cell cycle is crucial for maintaining normal cellular functions and preventing replication errors. FOXM1, a key transcription factor, plays a pivotal role in regulating cell cycle progression and is implicated in various physiological and pathological processes, including cancers like liver, prostate, breast, lung, and colon cancer. Despite previous research, our understanding of FOXM1 dynamics under different cell cycle perturbations and its connection to heterogeneous cell fate decisions remains limited. In this study, we investigated FOXM1 behavior in individual cells exposed to various perturbagens. We found that different drugs induce diverse responses due to heterogeneous FOXM1 dynamics at the single-cell level. Single-cell analysis identified six distinct cellular phenotypes: on-time cytokinesis, cytokinesis delay, cell cycle delay, G1 arrest, G2 arrest, and cell death, observed across different drug types and doses. Specifically, treatments with PLK1, CDK1, CDK1/2, and Aurora kinase inhibitors revealed varied FOXM1 dynamics leading to heterogeneous cellular outcomes. Our findings affirm that FOXM1 dynamics are pivotal in determining cellular outcomes, independent of the specific inhibitor employed. Our results gave insights into how FOXM1 dynamics contribute to cell cycle fate decisions, especially under different cell-cycle perturbations.
Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits
Authors: Peck Emily G. , Holleran Katherine M. , Curry Alyson M. , Holter Kimberly M. , Estave Paige M. , Sens Jonathon P. , Locke Jason L. , Ortelli Olivia A. , George Brianna E. , Dawes Monica H. , West Alyssa M. , Alexander Nancy J. , Kiraly Drew D. , Farris Sean P. , Gould Robert W. , McCool Brian A. , Jones Sara R. 
Published: July 2024

AbstractSynaptogyrin-3, a functionally obscure synaptic vesicle protein, interacts with vesicular monoamine and dopamine transporters, bringing together dopamine release and reuptake sites. Synaptogyrin-3 was reduced by chronic cocaine exposure in both humans and rats, and synaptogyrin-3 levels inversely correlated with motivation to take cocaine in rats. Synaptogyrin-3 overexpression in dopamine neurons reduced cocaine self-administration, decreased anxiety-like behavior, and enhanced cognitive flexibility. Overexpression also enhanced nucleus accumbens dopamine signaling and prevented cocaine-induced deficits, suggesting a putative therapeutic role for synaptogyrin-3 in cocaine use disorder.