bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Pipeline Embolization Device for the treatment of posterior circulation fusiform aneurysms: lessons learned at a single institution
Authors: Munich Stephan A. , Tan Lee A. , Keigher Kiffon M. , Chen Michael , Moftakhar Roham , Lopes Demetrius K. 
Published: September 2014

Object
Vertebrobasilar fusiform aneurysms (VFAs) are rare lesions characterized by abnormal dilation and tortuosity of the vertebral and/or basilar arteries. Untreated, these aneurysms have a tendency to progress, often resulting in neurological symptoms or rupture leading to subarachnoid hemorrhage. The microsurgical treatment of these lesions can be difficult due to their location and the circumferential involvement of the arteries. These features make microsurgical treatment prone to high morbidity. The Pipeline Embolization Device (PED) has gained popularity for the treatment of aneurysms of the internal carotid artery. Its use in the posterior circulation has been limited, likely due to a fear of perforating artery occlusion.

Methods
The authors retrospectively reviewed their database of patients treated with the PED and identified 12 patients who had VFAs. The clinical features, complications, and outcomes of these patients were analyzed.

Results
At an average follow-up of 11 months, the mean modified Rankin Scale score was 1.9. Complete aneurysm occlusion was seen in 90% of the patients with radiographic follow-up. Three patients suffered new neurological deficits postoperatively. One of these patients died, while the remaining 2 demonstrated significant clinical improvement at follow-up.

Conclusions
With attention to the anatomy of perforating arteries, staged contralateral vertebral artery sacrifice, and adequate platelet inhibition, PED may be an effective treatment option—alone or in a hybrid construct with stents of less coverage for VFAs—with an acceptable complication rate.
Resolution of cranial neuropathies following treatment of intracranial aneurysms with the Pipeline Embolization Device
Authors: Moon Karam , Albuquerque Felipe C. , Ducruet Andrew F. , Crowley R. Webster , McDougall Cameron G. 
Published: September 2014

Object
Intracranial aneurysms, especially those of the cavernous segment of the internal carotid artery (ICA), can present with cranial nerve (CN) palsies. The Pipeline Embolization Device (PED) has demonstrated safety and efficacy in the treatment of cerebral aneurysms by flow diversion, but little data exist reporting the outcomes of cranial neuropathies following treatment with the device.

Methods
The prospectively maintained Barrow Neurological Institute's endovascular database was reviewed for all patients treated with the PED after presenting with one or more CN palsies secondary to a cerebral aneurysm since May 2011. Patient charts and digital subtraction angiograms were reviewed to report clinical and angiographic outcomes. Only patients with clinical follow-up were included in the analysis.

Results
A total of 127 patients were treated with the PED at the authors' institution after FDA approval. Twentytwo patients presented with cranial neuropathies, for initial inclusion in this study. Of these, 20 had sufficient followup for analysis. Cranial neuropathies included those of CN II, III, V, and VI, with presenting symptoms of diplopia, decreased visual acuity, and facial numbness and/or pain. Thirteen lesions were cavernous segment ICA aneurysms, whereas the remainder included supraclinoid and petrous segment ICA, posterior communicating artery, and basilar trunk aneurysms. At an average clinical follow-up of 9.55 months, 15 patients (75%) had resolution or significant improvement of their cranial neuropathies, and the remaining 5 had stable symptoms. Of the 18 patients with angiographic follow-up, 12 (66.7%) demonstrated complete obliteration or small neck residual, whereas 6 (33.3%) had residual lesion. Patients with complete or near-complete obliteration of their lesion were significantly more likely to demonstrate symptomatic improvement at follow-up (p = 0.009). Two patients with persistent symptoms were eventually treated with microsurgical bypass. Transient complications in this series included 6 (30%) extracranial hemorrhagic complications related to dual-antiplatelet therapy, all of which were managed medically. There was 1 delayed right ICA occlusion following retreatment that led to microsurgical bypass.

Conclusions
Intracranial aneurysms presenting with one or more CN palsies show a high rate of clinical improvement after treatment with the PED. Clinical outcomes must be weighed against the risks and challenges faced with flow diverters. Further research is warranted for patients whose symptoms do not respond optimally to device placement.
Winteröffnung des Lukmanierpasses mit organisatorischen Massnahmen
Authors: Zürcher-Gasser Nora , Wilhelm Christian , Conceprio Fabrizio , Margreth Stefan 
Published: September 2014

Winter opening of the Lukmanier Pass, and accompanying organisational measures
On an experimental basis, the Lukmanier Pass has been open during ten winter seasons since winter 2000/2001, through the efforts of the Pro Lucmagn association. In 2010, a request was made to keep the pass open on a permanent basis, which led to a revision of the safety process and a re-evaluation of the risks. Overall, there has been a more significant reduction of risks than assumed initially, thanks to measures to close the road and trigger avalanches artificially. The estimated residual risks are at an acceptable level. Nevertheless, despite the chosen organisational measures there remain significant risks, which originate mostly from uncertainty connected with human judgement. Looking back, it appears that the risk analysis of 1998 was appropriate, and adequate to estimate in advance the trial operation of the winter opening of the Lukmanier Pass.
Erdheim-Chester disease with rare radiological features in a 14-year old girl with pre-B Acute Lymphocytic Leukemia and Diabetes mellitus
Authors: Krishna Varanasi Venkata Rama , Harvey James Teo Eu Leong , Chang Kenneth Tou En , Yen Soh Shui 
Published: August 2014

We report a case of a 14 year-old girl with Diabetes Mellitus who was in remission with pre-B cell Acute Lymphoblastic Leukemia and subsequently diagnosed with Erdheim-Chester disease. Erdheim-Chester disease is a non-Langerhans cell histiocytosis and is very rare in children. In addition, the radiological features of the lesions are atypical and have not been reported in children. There is no known association between the three conditions and this is the first reported case in the literature. A literature review of Erdheim-Chester disease will be performed.
Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories
Authors: Nikolich-Žugich Janko 
Published: September 2014

Abstract
Until the mid-20th century, infectious diseases were the major cause of morbidity and mortality in humans. Massive vaccination campaigns, antibiotics, antivirals, and advanced public health measures drastically reduced sickness and death from infections in children and younger adults. However, older adults (&gt;65 y of age) remain vulnerable to infections, and infectious diseases remain among the top 5–10 causes of death in this population. The aging of the immune system, often referred to as immune senescence, is the key phenomenon underlying this vulnerability. This review centers on age-related changes in T cells, which are dramatically and reproducibly altered with aging. I discuss changes in T cell production, maintenance, function, and response to latent persistent infection, particularly against CMV, which exerts a profound influence on the aging T cell pool, concluding with a brief list of measures to improve immune function in older adults.
Factors Associated with Delayed Cancer Diagnosis in Egyptian Children
Authors: Abdelkhalek E.R. , Sherief L.M. , Kamal N.M. , Soliman R.M. 
Published: September 2014

Background Despite tremendous importance of early cancer diagnosis in children, few studies on this topic have been conducted in Egypt. Early stage diagnosis can have a positive effect on prognoses and the quality of life of children with cancer. We investigated delays in the diagnosis of childhood cancers in Egypt and determined the factors associated with these delays. Methods This retrospective study included 172 children with cancer from two pediatric oncology units. The interval between symptoms onset and final diagnosis for each child was estimated and examined by univariate and multivariate analyses to determine correlations with the child's sex, age at diagnosis, type and site of malignancy, family residence, socioeconomic status, and parental educational level. Findings The median total diagnosis delay period was 47 days caused by patients and/or parents (8 days) and diagnosis (28 days). Statistically significant patient factors associated with delayed diagnosis were age (<5 years), lower parental education, and socioeconomic status. Sex residence and family size were not significant. Malignancy type and tumor site significantly affected the time for diagnosis. The lowest median value was associated with germ cell tumors (GCTs) and leukemia, and the highest value was in children with brain tumor. Missed diagnoses were initially recorded in 39.5% of the patients and were associated with patient and tumor factors. Interpretation Delayed diagnosis of childhood cancer is related to age, family, socioeconomic status and parental education, and cancer type and site. Efforts should be made to promote awareness, develop effective steps to eliminate possible contributing factors, and determine the best intervention method.
La obesidad en la resignificación de identidades infantiles indígenas en edad escolar en México: el caso de los pueblos Mazahua y Otomí
Authors: Vizcarra-Bordi Ivonne , Marín-Guadarrama Nadia 
Published: September 2014

En México, la obesidad infantil es un grave problema de salud pública relacionado con las consecuencias de la globalización y de los mercados agroalimentarios. Esta situación ha alcanzado a los infantes indígenas otomíes y mazahuas, quienes viven una constante reformulación de sus contextos étnicos, locales y familiares intrínsecamente interconectados con los procesos de globalización y que traen como consecuencia desigualdades sociales. Para saber cómo las identidades indígenas de los infantes con edad escolar se han reformulado, este artículo presenta un estudio sobre los contextos en los que los infantes viven su cotidianeidad junto con las variables de género, etnia, pobreza y cuerpo. Se empleó una metodología cualitativa junto con datos estadístico-descriptivos obtenidos de dos comunidades indígenas: Mazahua y Otomí. Se concluye que tanto el género como la pertenencia a una etnia y la situación de pobreza hacen que se discrimine a esta población infantil, y que se le estigmatice. Así, resulta incorrecto responsabilizar sólo a las madres o a los infantes mismos por las condiciones nutricionales en que viven, ya que sus decisiones alimentarias están determinadas por instituciones gubernamentales y no gubernamentales, así como nacionales e internacionales y de empresas de alimentos nacionales y globales.
Estudios etnográficos sobre el desarrollo infantil en comunidades indígenas de América Latina: contribuciones, omisiones y desafíos
Authors: Remorini Carolina 
Published: September 2014

En las últimas décadas, ha habido un progreso sustancial en el estudio del Desarrollo Infantil Temprano (DIT) desde perspectivas interdisciplinarias e transculturales. Varios autores reconocen la contribución de la antropología al debate sobre la primera infancia, en diálogo con la psicología, las neurociencias, la educación y la medicina. Estos estudios subrayan la importancia de los contextos ecológicos en lo que se refi ere al crecimiento físico, las trayectorias de desarrollo y los efectos sobre la salud a mediano y largo plazo. La Antropología hace hincapié en la noción de que el desarrollo de los niños depende de las interacciones que éstos entablan con su entorno inmediato y las actividades en las que participan. La importancia dada al ambiente desde una perspectiva ecológica reconoce el valor heurístico de los estudios etnográfi cos. En este trabajo caracterizamos, algunos ejes y modos de abordaje que se destacan en la producción etnográfi ca sobre infancia y desarrollo infantil en Latinoamérica, especialmente, sobre comunidades indígenas. En segundo lugar, analizamos y discutimos las posibilidades de interface entre la etnografía y las disciplinas que tradicionalmente se han ocupado del desarrollo infantil y refl exionamos sobre sus contribuciones en términos metodológicos a la comprensión de un proceso de carácter multidimensional, evitando los reduccionismos propios de cada mirada disciplinar. En relación a ello, discutimos los desafíos que la etnografía presenta en el contexto de la investigación inter y transdisciplinaria del DIT. Para concluir, reflexionamos sobre la necesidad de recuperar el DIT como objeto de estudio etnográfi co, como lo fue en los inicios de la disciplina.
Content Analysis of Five Occupational Therapy Journals, 2006–2010: Further Review of Characteristics of the Quantitative Literature
Authors: Pearl Andrew W. , Brennan Alexandra R. , Journey Tiffany I. , Antill Kayla D. , McPherson James J. 
Published: September 2014

AbstractOBJECTIVE. To analyze the content of publications in 5 occupational therapy journals to determine the strengths and weaknesses of the literature base from 2006 to 2010.METHOD. A content analysis for 2006 through 2010 of the American Journal of Occupational Therapy (AJOT), Australian Occupational Therapy Journal (AOTJ), British Journal of Occupational Therapy (BJOT), Canadian Journal of Occupational Therapy (CJOT), and Scandinavian Journal of Occupational Therapy (SJOT) was completed.RESULTS. AJOT and SJOT had the highest percentage of articles focusing on physical disabilities, whereas a majority of articles in AOTJ, BJOT, and CJOT focused on education. SJOT published articles with the highest median number of participants in all research designs excluding descriptive studies. The majority of the research articles were descriptive for all journals.CONCLUSION. From 2006 to 2010, AJOT provided stronger evidence conducted at higher levels than the other journals by publishing more articles investigating interventions used to support clinical practice.
Predictors of Motor, Daily Function, and Quality-of-Life Improvements After Upper-Extremity Robot-Assisted Rehabilitation in Stroke
Authors: Huang Pai-Chuan , Hsieh Yu-Wei , Wang Chin-Man , Wu Ching-Yi , Huang Shu-Chun , Lin Keh-Chung 
Published: September 2014

AbstractOBJECTIVE. A subgroup of patients benefiting most from robot-assisted therapy (RT) has not yet been described. We examined the predictors of improved outcomes after RT.METHOD. Sixty-six patients with stroke receiving RT were analyzed. The outcome measures were the Fugl-Meyer Assessment (FMA), Wolf Motor Function Test (WMFT), Motor Activity Log (MAL), and Stroke Impact Scale (SIS). The potential predictors were age, side of lesion, time since onset, Modified Ashworth Scale (MAS) scores, accelerometer data, Box and Block Test (BBT) scores, and kinematic parameters.RESULTS. BBT scores were predictive of FMA (29%) and MAL (9%−15%) improvements. Reduced shoulder flexion synergy, as measured by less shoulder abduction during forward reach, and MAS–distal were predictive of WMFT–function improvements. MAS–distal was predictive of SIS–physical improvements. Demographic variables did not predict outcomes.CONCLUSION. Manual dexterity was a valuable predictor of motor impairment and daily function after RT. Outcomes at different levels may have different predictors.
Content and Construct Validity of Here’s How I Write (HHIW): A Child’s Self-Assessment and Goal Setting Tool
Authors: Cermak Sharon A. , Bissell Julie 
Published: September 2014

Abstract
OBJECTIVE. We examined content and construct validity of Here’s How I Write: A Child’s Self-Assessment and Goal Setting Tool, to assess children’s perception of their handwriting and set child-directed goals.
METHOD. In Study 1, a content validity study, 6 occupational therapists and 2 educators assessed the need for this type of measure and examined the proposed items. Thirty-four occupational therapists and educators then completed an online survey examining the items. Study 2, a construct validity study, compared the self-ratings of 20 children with poor handwriting and 20 children with good handwriting in Grades 2–5 with their teachers’ ratings.
RESULTS. Results supported test content and indicated freedom from culture and gender bias. The assessment discriminated between good and poor writers. The relationship between teacher and student ratings was significant, although teachers of poor writers rated the children lower than the children rated themselves.
CONCLUSION. These studies provide support for the tool’s validity.
Interrater Reliability and Discriminative Validity of the Structural Elements of the Ayres Sensory Integration® Fidelity Measure©
Authors: May-Benson Teresa A. , Roley Susanne Smith , Mailloux Zoe , Parham L. Diane , Koomar Jane , Schaaf Roseann C. , Van Jaarsveld Annamarie , Cohn Ellen 
Published: September 2014

Abstract
This study examined the reliability and validity of the structural section of the Ayres Sensory Integration® Fidelity Measure© (ASIFM), which provides a method for monitoring the extent to which an intervention was implemented as conceptualized in studies of occupational therapy using sensory integration intervention methods (OT–SI). We examined the structural elements of the measure, including content of assessment reports, availability of specific equipment and adequate space, safety monitoring, and integration of communication with parents and other team members, such as collaborative goal setting with parents or family and teacher education, into the intervention program. Analysis of self-report ratings by 259 occupational therapists from 185 different facilities indicated that the structural section of the ASIFM has acceptable interrater reliability (r ≥ .82) and significantly differentiates between settings in which therapists reportedly do and do not practice OT–SI (p &lt; .001).
Evidence-Based Review of Interventions for Medically At-Risk Older Drivers
Authors: Classen Sherrilene , Monahan Miriam , Auten Beth , Yarney Abraham 
Published: September 2014

AbstractOBJECTIVE. To conduct an evidence-based review of intervention studies of older drivers with medical conditions.METHOD. We used the American Occupational Therapy Association’s classification criteria (Levels I–V, I = highest level of evidence) to identify driving interventions. We classified studies using letters to represent the strength of recommendations: A = strongly recommend the intervention; B = recommend intervention is provided routinely; C = weak evidence that the intervention can improve outcomes; D = recommend not to provide the intervention; I = insufficient evidence to recommend for or against the intervention.RESULTS. For clients with stroke, we recommend a graded simulator intervention (A) and multimodal training in traffic theory knowledge and on-road interventions (B); we make no recommendation for or against Dynavision, Useful Field of View, or visual–perceptual interventions (I). For clients with visual deficits, we recommend educational intervention (A) and bioptic training (B); we make no recommendation for or against prism lenses (I). For clients with dementia, we recommend driving restriction interventions (C) and make no recommendation for or against use of compensatory driving strategies (I).CONCLUSION. Level I studies are needed to identify effective interventions for medically at-risk older drivers.
Feasibility of High-Repetition, Task-Specific Training for Individuals With Upper-Extremity Paresis
Authors: Waddell Kimberly J. , Birkenmeier Rebecca L. , Moore Jennifer L. , Hornby T. George , Lang Catherine E. 
Published: September 2014

Abstract
OBJECTIVE. We investigated the feasibility of delivering an individualized, progressive, high-repetition upper-extremity (UE) task-specific training protocol for people with stroke in the inpatient rehabilitation setting.
METHOD. Fifteen patients with UE paresis participated in this study. Task-specific UE training was scheduled for 60 min/day, 4 days/wk, during occupational therapy for the duration of a participant’s inpatient stay. During each session, participants were challenged to complete ≥300 repetitions of various tasks.
RESULTS. Participants averaged 289 repetitions/session, spending 47 of 60 min in active training. Participants improved on impairment and activity level outcome measures.
CONCLUSION. People with stroke in an inpatient setting can achieve hundreds of repetitions of task-specific training in 1-hr sessions. As expected, all participants improved on functional outcome measures. Future studies are needed to determine whether this high-repetition training program results in better outcomes than current UE interventions.
Effectiveness of Cognitive–Functional (Cog–Fun) Occupational Therapy Intervention for Young Children With Attention Deficit Hyperactivity Disorder: A Controlled Study
Authors: Maeir Adina , Fisher Orit , Bar-Ilan Ruthie Traub , Boas Naomi , Berger Itai , Landau Yael E. 
Published: September 2014

Abstract
OBJECTIVE. The purpose of this study was to examine the effectiveness of the Cognitive–Functional (Cog–Fun) intervention for young children with attention deficit hyperactivity disorder (ADHD).
METHOD. Nineteen children ages 5–7 yr diagnosed with ADHD were allocated to treatment and wait-list control groups. After the 12-wk intervention, the control group was crossed over to treatment. Follow-up was conducted 3 mo after treatment. Outcome measures included the Behavior Rating Inventory of Executive Function and the Canadian Occupational Performance Measure.
RESULTS. Before crossover, significant differences were found between groups in change scores on the outcome measures. After crossover, no significant differences were found in treatment effects, and significant moderate to large treatment effects were found for both COPM and BRIEF scores. Treatment gains were maintained at follow-up.
CONCLUSION. The study supports the effectiveness of the Cog–Fun intervention in improving occupational performance and executive functions in daily life for young children with ADHD.
Shear Bond Strength of Self-Adhering Flowable Composite on Dentin with and without Application of an Adhesive System
Authors: Tuloglu Nuray , Tunc Emine Sen , Ozer Sezin , Bayrak Sule 
Published: September 2014

Purpose The aim of this study was to evaluate the shear bond strength (SBS) of conventional and self-adhering flowable resin composites on the dentin surfaces of primary and permanent teeth and to evaluate the effect of the application of an adhesive system under self-adhering flowable resin composite on SBS. Methods Prepared permanent and primary tooth dentin surfaces were randomly distributed into 3 groups according to application protocols as follows: group 1: Vertise Flow; group 2: OptiBond + Filtek Ultimate; and group 3: OptiBond + Vertise Flow. A universal testing machine was used to measure SBS of prepared specimens, and data were analyzed using 1-way ANOVA and Tukey test. Results Statistically significant differences were observed among all groups for primary and permanent teeth (P<0.05). The highest values were observed in group 2, followed by group 3, in both permanent and primary teeth. SBSs of all groups were significantly higher for permanent teeth than for primary teeth (P<0.05). Conclusion Although SBS values of Vertise Flow groups were lower than those for conventional flowable resin composite groups, with further developments in material technology, self-adhering materials could be promising materials especially for pediatric dentistry.