bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of thyroidectomy in symptomatic, euthyroid Hashimoto's patients: a case control study
Authors: Serrao‐Brown Hazel , Saadi Amna , Wong Jessica , Papachristos Alexander , Sywak Mark , Sidhu Stan 
Published: July 2024

AbstractBackgroundHashimoto's thyroiditis (HT) is managed with thyroid hormone replacement to maintain a euthyroid state. A subset of patients have refractory symptoms, which improve with thyroidectomy (TT). There remains a reluctance to proceed with surgery due to perceptions of complications, and limited data availability regarding improvements in quality of life (QoL). This retrospective case control study aims to analyse the outcomes and QoL scores for symptomatic euthyroid HT patients who underwent TT.MethodsThirty euthyroid patients who underwent TT for the management of HT between 2017 and 2022 were identified. An age‐matched control group of patients who underwent TT for symptomatic multinodular goitre (MNG) were randomly selected. Demographics, biochemistry, histology, outcomes, and pre‐ and post‐operative SF‐36 and ThyPRO‐39 scores were compared between groups.ResultsThere were no surgical complications in the HT group, whilst two MNG patients had complications. There was a similar rate of parathyroid auto‐transplantation in both groups, more glands were transplanted in the HT group. There was a significant difference in pre‐ and post‐operative QoL scores for both groups. Comparison revealed a significant improvement in hyperthyroid symptoms, social life and daily life scores in the HT group. There was a significant difference in pre‐ and post‐operative anti‐TPO, anti‐TG and TSH levels in the HT group.ConclusionPatients with symptomatic Hashimoto's thyroiditis, despite being euthyroid, may benefit from total thyroidectomy however this remains under‐utilized. This study demonstrated that thyroidectomy was associated with an improvement in validated post‐operative quality of life scores and was not associated with increased complication rates for appropriately selected patients.
Clinical performance of human papillomavirus based cervical cancer screening algorithm: The result of a large Danish implementation study
Authors: Lindquist Sofie , Kjær Susanne K. , Frederiksen Kirsten , Ørnskov Dorthe , Petersen Lone Kjeld , Munk Christian , Waldstrøm Marianne 
Published: July 2024

AbstractIntroductionIn Denmark, where human papillomavirus (HPV) ‐based cervical cancer screening is being implemented, the aim of this pilot implementation study was to test a specific screening algorithm, assess follow‐up examination attendance, and measure the proportion of precancer lesions found in relation to the number of women referred for colposcopy.Material and MethodsFrom May 2017 to December 2020, 36 417 women in the uptake area of the Department of Pathology, Vejle Hospital, Region of Southern Denmark, were included in the HPV group. Women positive for HPV16/18 irrespective of cytology and women positive for other high‐risk HPV (hrHPV) types having concomitant abnormal cytology were referred directly to colposcopy. Women positive for other hrHPV types and normal cytology were referred to repeat screening after 12 months, and hrHPV negative to routine screening after three years. We obtained information on screening results and subsequent histological diagnosis from the Danish Pathology Databank through September 2022.Results3.6% of the women were referred to colposcopy after primary screening, 5% to repeat screening after 12 months, and 91.4% back to routine screening. High follow‐up rates were observed: 96% attended colposcopy after primary screening, with 91% attending colposcopy after repeat screening. CIN3+ was detected at colposcopy following the primary screening in 28.1% of HPV16/18‐positive women and 18.2% of those positive for other hrHPV types with concomitant abnormal cytology. Of the women with other hrHPV and simultaneous ASCUS/LSIL, 8% had CIN3+. At the repeat screening, 43% had become hrHPV negative, 55% were persistently positive for other hrHPV, and 2% had turned positive for HPV16/18. At the colposcopy following repeat screening, 10.1% of the women positive for other hrHPV were diagnosed with CIN3+, in comparison with 11.1% of the HPV16/18‐positive women.ConclusionsIn this pilot implementation study, an algorithm for HPV‐based screening was evaluated in a Danish setting. The results demonstrated high attendance at follow‐up examinations and provided insights into the number of colposcopy referrals and the detection of CIN2 and CIN3+ cases. The results suggest that women testing positive for other hrHPV in combination with ASCUS/LSIL at primary screening could potentially be referred to repeat screening instead of an immediate colposcopy.
Pluriversal bodies: Researching care through embodied ethnography
Authors: Dombroski Kelly 
Published: July 2024

AbstractIn this research note, I outline an approach to embodied experiences of care and caregiving in ethnographic scholarship on care. I describe how ethnographers of care and caregiving can use embodied methodologies, particularly through attending also to the cross‐cultural differences in embodied experiences. In this research note, I bring together care research and cross‐cultural embodied ethnography with my own work in Asia Pacific to outline an approach to researching care in the pluriverse – the multiple, overlapping realities of ontology, culture and experience that underpin all our lives. I draw on Annemarie Mol's conceptualisation of the body multiple (2002), Anna Tsing's understanding of awkward engagement (2005), Gibson‐Graham's reading for difference (2020) and Sean Hsiang‐lin Lei's research on hygiene (2014) to consider how researcher bodies might be useful in detecting pluriversal encounters in caregiving.
The neuroprotective effects of normobaric oxygen therapy after stroke
Authors: Li Chuan , Jiang Min , Chen Zhiying , Hu Qiongqiong , Liu Ziying , Wang Junmin , Yin Xiaoping , Wang Jian , Wu Moxin 
Published: July 2024

AbstractBackgroundStroke, including ischemic and hemorrhagic stroke, is a severe and prevalent acute cerebrovascular disease. The development of hypoxia following stroke can trigger a cascade of pathological events, including mitochondrial dysfunction, energy deficiency, oxidative stress, neuroinflammation, and excitotoxicity, all of which are often associated with unfavorable prognosis. Nonetheless, a noninvasive intervention, referred to as normobaric hyperoxia (NBO), is known to have neuroprotective effects against stroke.ResultsNBO can exert neuroprotective effects through various mechanisms, such as the rescue of hypoxic tissues, preservation of the blood–brain barrier, reduction of brain edema, alleviation of neuroinflammation, improvement of mitochondrial function, mitigation of oxidative stress, reduction of excitotoxicity, and inhibition of apoptosis. These mechanisms may help improve the prognosis of stroke patients.ConclusionsThis review summarizes the mechanism by which hypoxia causes brain injury and how NBO can act as a neuroprotective therapy to treat stroke. We conclude that NBO has significant potential for treating stroke and may represent a novel therapeutic strategy.
Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is associated with lower visceral and hepatic lipid content in recent‐onset type 1 diabetes and type 2 diabetes
Authors: Schaefer Edyta , Lang Alexander , Kupriyanova Yuliya , Bódis Kálmán B. , Weber Katharina S. , Buyken Anette E. , Barbaresko Janett , Kössler Theresa , Kahl Sabine , Zaharia Oana‐Patricia , Szendroedi Julia , Herder Christian , Schrauwen‐Hinderling Vera B. , Wagner Robert , Kuss Oliver , Roden Michael , Schlesinger Sabrina ,   GDS Group
Published: July 2024

AbstractAimTo investigate the associations of the Dietary Approaches to Stop Hypertension (DASH) score with subcutaneous (SAT) and visceral (VAT) adipose tissue volume and hepatic lipid content (HLC) in people with diabetes and to examine whether changes in the DASH diet were associated with changes in these outcomes.MethodsIn total, 335 participants with recent‐onset type 1 diabetes (T1D) and type 2 diabetes (T2D) from the German Diabetes Study were included in the cross‐sectional analysis, and 111 participants in the analysis of changes during the 5‐year follow‐up. Associations between the DASH score and VAT, SAT and HLC and their changes were investigated using multivariable linear regression models by diabetes type. The proportion mediated by changes in potential mediators was determined using mediation analysis.ResultsA higher baseline DASH score was associated with lower HLC, especially in people with T2D (per 5 points: −1.5% [−2.7%; −0.3%]). Over 5 years, a 5‐point increase in the DASH score was associated with decreased VAT in people with T2D (−514 [−800; −228] cm3). Similar, but imprecise, associations were observed for VAT changes in people with T1D (−403 [−861; 55] cm3) and for HLC in people with T2D (−1.3% [−2.8%; 0.3%]). Body mass index and waist circumference changes explained 8%‐48% of the associations between DASH and VAT changes in both groups. In people with T2D, adipose tissue insulin resistance index (Adipo‐IR) changes explained 47% of the association between DASH and HLC changes.ConclusionsA shift to a DASH‐like diet was associated with favourable VAT and HLC changes, which were partly explained by changes in anthropometric measures and Adipo‐IR.
Goods market desirability of minimum wages
Authors: Pan Rui , Zeng Dao‐Zhi 
Published: July 2024

AbstractThis paper presents a general equilibrium model incorporating heterogeneous firms and a perfectly competitive labour market to explore the desirability of minimum wages. We demonstrate that a low minimum wage could enhance social welfare, assuming equal weighting for all individuals. This occurs because the introduction of minimum wages has the potential to mitigate the goods market distortions arising from imperfect competition, firm heterogeneity and free entry. Additionally, we illustrate that the optimal minimum wage is positively associated with the preference intensity for differentiated products relative to the numeraire and population size, while it negatively correlates with the degree of love for variety, entry cost, and upper bound of marginal labour requirements.
A deep learning approach for high‐resolution mapping of Scottish peatland degradation
Authors: Macfarlane Fraser , Robb Ciaran , Coull Malcolm , McKeen Margaret , Wardell‐Johnson Douglas , Miller Dave , Parker Thomas C. , Artz Rebekka R. E. , Matthews Keith , Aitkenhead Matt J. 
Published: July 2024

AbstractPeat makes up approximately a quarter of Scotland's soil by area. Healthy, undisturbed, peatland habitats are critical to providing resilient biodiversity and habitat support, water management, and carbon sequestration. A high and stable water table is a prerequisite to maintain carbon sink function; any drainage turns this major terrestrial carbon store into a source that feeds back further to global climate change. Drainage and erosion features are crucial indicators of peatland condition and are key for estimating national greenhouse gas emissions. Previous work on mapping peat depth and condition in Scotland has provided maps with reasonable accuracy at 100‐m resolution, allowing land managers and policymakers to both plan and manage these soils and to work towards identifying priority peat sites for restoration. However, the spatial variability of the surface condition is much finer than this scale, limiting the ability to inventory greenhouse gas emissions or develop site‐specific restoration and management plans. This work involves an updated set of mapping using high‐resolution (25 cm) aerial imagery, which provides the ability to identify and segment individual drainage channels and erosion features. Combining this imagery with a classical deep learning‐based segmentation model enables high spatial resolution, national scale mapping to be carried out allowing for a deeper understanding of Scotland's peatland resource and which will enable various future analyses using these data.
Translation and psychometric properties of the Arabic version of the ageism scale for dental students (ASDS‐Ar): A multi‐institutional validation
Authors: Alhajj Mohammed Nasser , Omar Ridwaan , Al‐Maweri Sadeq Ali , Alsoghier Abdullah M. , El Tantawi Maha , Khader Yousef , Al‐Ansari Asim , Aseri Abdulrahman , Amran Abdullah G. , AlBatayneh Ola B. , Samran Abdulaziz , Alqutaibi Ahmed Yaseen , Alqahtani Ahmed Shaher , AlDhelai Thiyezen Abdullah , Faheemuddin Muhammad , Umer Muhammad Farooq , Assad Mounzer , Barngkgei Imad , Agwa Tarek Abou , Murad Ali H. , Makzoumé Joseph E. , Arheiam Arheiam , Ballo Lamis , Mufadhal Abdulbaset A. , Al‐Wesabi Mohammed A. , Alhajj Wadhah A. , Elkholy Sahar , Osman Sarah M. , Halboub Esam 
Published: July 2024

Background and ObjectiveAgeism represents an important barrier to high‐quality healthcare for older adults. The present study sought to translate and validate the Arabic version of the Ageism Scale for Dental Students (ASDS‐Arabic).Materials and MethodsThe 27‐item ASDS tool was translated from English into Arabic following recommended cross‐sectional forward and backward translation guidelines. The translated version was subjected to the content validity ratio (CVR) and sent to dental students in 21 institutes from 10 different Arab countries. Principal components analysis (PCA) was used to assess the dimensionality of the scale, and Cronbach's alpha was used to determine internal consistency reliability. The discriminant validity of the scale was assessed using the independent t‐test. Confirmatory factor analysis (CFA) was also undertaken.ResultsBased on CVR, three items were removed. The 24‐item Arabic version was completed by 3284 dental students. PCA and CFA retained 17 items in six components, explaining 50.3% of the total variance, with acceptable reliability, validity and discrimination. The first component “Adherence of older patients with dental treatment and instructions,” included four items with a Cronbach α of 0.64 and scored 4.3 ± 0.8. The second component “Feasibility of the treatment plan,” included three items with a Cronbach α of 0.66 and scored from 2.6 ± 1.2 to 2.9 ± 1.1. The third component “Cost of and responsibility for the dental treatment” included four items with a Cronbach α of 0.47 and scored 4.4 ± 0.8 to 4.5 ± 0.8. The fourth component “Medical history of older patients” included two items with a Cronbach α of 0.70 and scored 4.0 ± 1.0 to 4.1 ± 1.0. The fifth Component “Feeling towards older patients” included two items with a Cronbach α of 0.672 and scored 2.6 ± 1.2 to 2.0 ± 1.4. The sixth Component “Confidence and experience in treating older patients” included two items with a Cronbach α of 0.33 and scored 4.4 ± 1 to 4.6 ± 1.ConclusionThis preliminary validation of the ASDS‐Ar resulted in a new 17‐item scale with six components with acceptable validity, reliability and discrimination.
Efficacy of a 1:1 ratio VWF/FVIII concentrate in patients with von Willebrand disease
Authors: Kuppens Geoffrey Z. L. , Fischer Kathelijn , van Galen Karin P. M. , van Beers Eduard J. , Van der Valk Paul R. , Kremer Hovinga Idske C. L. , van Vulpen Lize F. D. , Schutgens Roger E. G. 
Published: July 2024

AbstractIntroductionPatients with von Willebrand disease (VWD) require administration of von Willebrand factor (VWF) concentrates peri‐operatively. Concerns about FVIII accumulation after repetitive injections of a 1:1 ratio VWF/FVIII clotting factor concentrate (CFC) led this study to explore the recovery and FVIII accumulation over time.MethodsThis monocentre study examined patients with VWD receiving perioperative 1:1 ratio CFC infusions. CFC dosing was based on body weight and endogenous VWF/FVIII activity. FVIII and VWF activity was monitored at T0 (baseline), T1 (15 min postinfusion), and trough levels at T2‐T6 (24‐120 h).ResultsWe included 125 patients, undergoing 125 procedures (63 major surgeries, 62 minor), with a median of two CFC infusions (IQR 1–3). With a mean administered dose of 35.7 IU/kg CFC, recovery rates of FVIII and VWF were 2.6 IU/dL per IU/kg and 2.4 IU/dL per IU/kg, respectively. Mean FVIII levels at T0 were 62 (SD 51.9), T1: 164 (SD 80.4), T2: 155 (SD 62.8), T3: 162 (SD 59.8), T4: 124 (SD 78.4), and T5: 120 (SD 65.3) IU/dL. Mean VWF activity levels at T0 were 29 (SD 25.0), T1: 133 (SD 43.7), T2: 92 (SD 37.2), and T3: 86 (SD 37.5) IU/dL. Subgroup analysis in 47 patients with more than three infusions, showed no accumulation of mean FVIII levels.ConclusionThis perioperative study demonstrated excellent FVIII and VWF recovery of a 1:1 ratio VWF product in patients with VWD. Stable FVIII and VWF activity levels were observed after repeated infusions, without accumulation. Most major surgeries required only three CFC infusions.
Network structure and taxonomic composition of tritrophic communities of Fagaceae, cynipid gallwasps and parasitoids in Sichuan, China
Authors: Fang Zhiqiang , Tang Chang‐Ti , Sinclair Frazer , Csóka György , Hearn Jack , McCormack Koorosh , Melika George , Mikolajczak Katarzyna M. , Nicholls James A. , Nieves‐Aldrey José‐Luis , Notton David G. , Radosevic Sara , Bailey Richard I. , Reiss Alexander , Zhang Yuanmeng M. , Zhu Ying , Fang Shengguo , Schönrogge Karsten , Stone Graham N. 
Published: July 2024

Abstract
A key question in insect community ecology is whether parasitoid assemblages are structured by the food plants of their herbivore hosts.
Tritrophic communities centred on oak‐feeding cynipid gallwasps are one of the best‐studied tritrophic insect communities. Previous work suggests that host plant identity is a much stronger predictor of oak–cynipid interactions than of cynipid–parasitoid interactions. However, these relationships have not been formally quantified.
We reason that the potential for ‘bottom‐up’ effects should increase with host plant phylogenetic diversity. We, therefore, generated quantified interaction network data for previously unstudied tritrophic cynipid communities in Sichuan, China, where, in addition to Quercus, cynipid host plants include Castanea, Castanopsis and Lithocarpus. We characterise these communities taxonomically and compare the extent to which host plant taxonomy predicts plant–herbivore and plant–parasitoid associations.
We sampled 42,620 cynipid galls of 176 morphotypes from 23 host plant species, yielding over 4500 specimens of 64 parasitoid morphospecies. Many parasitoids were identifiable to chalcidoid taxa present in other Holarctic oak cynipid communities, with the addition of Cynipencyrtus (Cynipencyrtidae). As elsewhere, Sichuan parasitoid assemblages were dominated by generalists.
Gallwasp–plant interaction networks were significantly more modular than parasitoid–plant association networks. Gallwasps were significantly more specialised to host plants (i.e. had higher mean d' values) than parasitoids. Parasitoid assemblages nevertheless showed significant plant‐associated beta diversity, with a dominant turnover component.
We summarise parallels between our study and other Fagaceae‐associated cynipid communities and discuss our findings in light of the processes thought to structure tritrophic interactions centred on endophytic insect herbivores.
Superficial circumflex iliac artery perforator propeller flap for penoscrotal extramammary Paget's disease
Authors: Dong Wenfang , Xiao Xiaodi , Wang Zheng , Yang Xin , Bi Hongsen 
Published: July 2024

AbstractBackgroundExtramammary Paget's disease (EMPD) is a rare intra‐epidermal adenocarcinoma, and reconstruction of the penoscrotal region remains a clinical challenge. The superficial circumflex iliac artery perforator (SCIP) flap has been successfully used as a free flap, while its application as a propeller flap in the reconstruction of penoscrotal EMPD defect is rarely reported. The objective was to evaluate the safety and efficacy of the SCIP propeller flap in the reconstruction of penoscrotal defects in EMPD.MethodsBetween September 2010 and August 2022, consecutive patients diagnosed with penoscrotal EMPD were enrolled. All patients underwent penoscrotal EMPD excision and reconstruction with SCIP propeller flap combined with other flaps or skin grafts on individual defects. Demographic information, surgical parameters, postoperative complications, patient satisfaction, and recurrence rates were analyzed.ResultsTwenty‐four patients (mean age, 73 ± 8.8 years; mean BMI, 23.98 ± 3.62 kg/m2) with 33 SCIP propeller flaps (mean size 120.1 cm2; range, 24–208 cm2) were included, and the mean defect size was 67.4 cm2 (range, 12–255 cm2). The mean operative duration was 385.4 ± 146.8 min. Fifteen patients received autologous full‐thickness skin grafts, and four received other flaps simultaneously. All flaps survived without total or partial loss, and all donor sites achieved primary closure, though local hematoma (one case) and limited skin graft necrosis (two cases) were observed. All patients experienced complete wound healing and maintained penoscrotal morphology and function without recurrent lesions over a mean follow‐up of 59 months.ConclusionsThe SCIP propeller flap seems a safe and effective reconstructive method for penoscrotal EMPD.Level of evidenceIV.
Outcomes and prognostic factors in patients with synchronous and metachronous oligometastatic urothelial carcinoma with visceral metastases
Authors: Yoshida Soichiro , Maezawa Yuya , Ishihara Kensaku , Inoue Naoki , Tanabe Kenji , Izumi Keita , Fujiwara Motohiro , Toide Masahiro , Yamamoto Takanobu , Uehara Sho , Araki Saori , Inoue Masaharu , Takazawa Ryoji , Numao Noboru , Ohtsuka Yukihiro , Tanaka Hajime , Fujii Yasuhisa 
Published: July 2024

AbstractObjectivesTo evaluate the clinical characteristics of oligometastatic disease (OMD) in metastatic urothelial carcinoma (mUC) with visceral metastases when classified into synchronous and metachronous metastases.MethodsOf 957 cases of de novo mUC treated between 2008 and 2023, 374 with visceral metastases were analyzed. Cases were classified into OMD with up to three metastatic lesions and polymetastatic disease (PMD), and into synchronous and metachronous metastases. The clinical characteristics and overall survival (OS) for each group were analyzed.ResultsOverall, 196 (52.4%) had synchronous metastasis and 178 (47.6%) had metachronous metastasis. Median OS for synchronous metastases was significantly shorter than for metachronous metastases (12.1 months vs. 15.3 months, p = 0.011). Among the synchronous metastases, 48 (24.5%) were OMD and 148 (75.6%) were PMD. There was no significant difference in OS between the OMDs and PMDs (median 14.9 months vs. 11.7 months, p = 0.32), and only decreased albumin level was identified as a significant predictor of poor OS. Among the metachronous metastases, 64 (36.0%) were OMD and 114 (64.0%) were PMD. There was no significant difference in OS between the OMD and PMD (median 21.2 months vs. 15.0 months, p = 0.35), and no significant predictors of poor OS were identified.ConclusionsFor mUC with visceral metastases, the timing of metastasis appearance was associated with prognosis, with synchronous metastases being a poorer prognostic factor compared to metachronous metastases. There was no prognostic difference between OMD and PMD with visceral metastases when classified into synchronous or metachronous metastases.