bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prendre soin par la couleur : du design tinctorial au care
Authors: Talbot Delphine , Mardirossian Vanessa 
Published: July 2024

Cet article explore la multidimensionnalité du médium couleur, en lien avec les teintures textiles. Il offre une perspective novatrice sur la relation complexe entre la création artistique et l’impact que la couleur peut avoir sur la santé selon les ingrédients qui la composent. À l’instar du philosophe Marshall McLuhan, pour qui « le contenu de tout médium est toujours un autre médium », les autrices fusionnent leur approche réflexive sur l’identité moléculaire des colorants, dont l’invisibilité est souvent « négligée » au profit de leur séduisante esthétique, qui occulte leur « caractère » toxique (McLuhan, 1964). La complémentarité d’expertises des autrices offre une pluralité de points de vue : d’une part, une approche systémique et biomimétique des couleurs, mêlant design, chimie et santé environnementale, d’autre part, l’aspect culturel, polysensoriel et botanique du médium couleur. Conjointement, les autrices aspirent à valoriser des richesses chromatiques anciennes et prospectives, en tout cas oubliées ou méconnues, afin de contribuer au développement pédagogique et industriel de colorants respectueux de l’environnement et de l’humain.
Une critique de l’hylémorphisme dans les théories du design d’interaction : recherche de concepts dans la philosophie pour appréhender la forme et la matérialité
Authors: Letondal Catherine , Giroud Guillaume , Pauchet Sylvain , Bornes Laetitia 
Published: July 2024

La recherche d’une compréhension de l’émergence d’un design sur le plan de la forme et de la matière est ancienne. On observe une montée en puissance du concept de forme dans la littérature scientifique sur le design d’interaction, en parallèle d’un tournant matériel, pour exprimer les forces à l’œuvre dans la conception. Dans cet article, nous soulignons en quoi les théories actuelles nous semblent implicitement construites sur le paradigme hylémorphique, et ce, de manière peu cohérente. Pour rendre compte plus finement des mécanismes d’élaboration et de conception dans le design d’interaction, nous proposons d’utiliser les concepts explicites de transduction, de métastabilité, d’individuation et de concrétisation, tirés de l’approche critique du schéma hylémorphique de Gilbert Simondon. Au paradigme hylémorphique de la mise en forme aristotélicienne, nous opposons ainsi celui, transductif, de la prise de forme . Pour une meilleure compréhension, nous présentons une illustration de ces concepts dans un exemple : un dispositif tactile à changement de forme pour les pilotes d’avion de ligne.
Tranexamic Acid Reduces the Amount of Blood Transfused in Revision Total Hip Arthroplasty for Vancouver B2/B3 Periprosthetic Femur Fractures
Authors: Connors John Patrick , Magaldi Robert James , Strecker Sara Elaine , Carangelo Robert James , Witmer Dan 
Published: July 2024

Background:
Periprosthetic fractures around total hip arthroplasty (THA) represent a significant source of morbidity and mortality. The use of tranexamic acid (TXA) in arthroplasty is well described, yet little literature supports its role in periprosthetic femur fractures (PFFs). This study investigated the effect of preoperative TXA administration on transfusion rate and volume, length of stay, and 90-day complication rates in patients undergoing revision THA for PFF.

Materials and Methods:
All patients undergoing revision THA for PFF (Vancouver B2/B3) at our institution from August 2016 to June 2022 were identified. Routine TXA administration at surgical start was introduced in 2018. Patient demographics, operative time, blood product use, length of stay, and 90-day complications were collected. Patients were divided into those who received TXA preoperatively and those who did not.

Results:

A total of 56 patients were included. There was no difference in age, sex, anesthetic type, fracture classification, or preoperative blood values between cohorts. TXA significantly lowered the amount of blood product required (2.3 units vs 3.2 units,
P
=.023). Preoperative TXA did not independently reduce length of stay; however, blood transfusion was associated with increased length of stay (7 days vs 4.7 days,
P
=.003). There were no differences in 90-day complications.

Conclusion:

Among patients who underwent revision THA for Vancouver B2/B3 PFF, TXA did not affect transfusion rates but did result in the use of fewer blood products without an increase in complications. We support routine use of TXA in this patient population. Future studies should assess earlier administration of TXA in the emergency department or once patients' conditions have been medically optimized. [
Orthopedics
. 2024;47(5):e261–e267.]
IL-10 Is Critical for Regulation of Cytotoxic CD4+NKG7+ T Cells in Lung Allograft Rejection but Is Not Required for Allograft Acceptance
Authors: Das Antu , Wang Xingan , Devonshire Kaitlyn , Lyons Emily J , Popescu Iulia , Zhou Zihe , Li Jingmei , Sembrat John , Pilewski Joseph , Zou Chunbin , Alder Jonathan K , Chen Bill B , Snyder Mark E , McDyer John F 
Published: July 2024

Abstract
Lung transplant remains the primary therapeutic option for patients with end-stage lung disease, but long-term survival rates remain suboptimal compared with other solid organ transplants. Acute cellular rejection (ACR) is a significant challenge in lung transplant recipients, with T cell–mediated mechanisms playing a major role. IL-10 is known for its immunoregulatory function, although its specific role in lung allograft rejection remains unclear. Using the mouse orthotopic lung transplant model, we investigated the role of IL-10 in regulating alloeffector T cell responses. Unexpectedly, we found that IL-10 was not required for early costimulation blockade-induced allograft acceptance. However, IL-10 deficiency or blockade resulted in increased CD4+ T cell numbers, proliferation, graft infiltration, and alloeffector responses. In the absence of IL-10, CD4+ T cell responses predominated over CD8 responses during ACR in contrast to wild-type mice. Type 1 immunity (IFN-γ) responses along with elevated CD4+NKG7+ and CD4+CD107a+ responses predominated during ACR, highlighting a critical regulatory role for IL-10 in modulating CD4+ T cell alloimmune responses. We further demonstrated increased colocalization of NKG7 and CD107a in CD4+ T cells from IL-10-deficient allografts, suggesting coordination in cytotoxic activity. Together, our findings highlight a critical role for IL-10 in regulation of cytotoxic CD4+NKG7+ T cells, an effector population that needs further investigation to elucidate their role in lung allograft rejection.
Prevalence of Thyroid Nodules and Predictive Factors for their Malignancy: Is there any Correlation between Level of TSH and Type of Malignancy?: A Cross Sectional Study
Authors: Moradi Leila , Hani Tabaei Zavareh Mohsen , Zaman Ferdos , Shareghi Bruojeni Anahita , Taravati Seyed Amir Mohammad , Naderi Boldaji Hossein , Rostami Koushan , Shahrokh Seyedeh Ghazal 
Published: July 2024

Background:
Thyroid nodule is a common finding of the endocrine system. Despite thyroid nodules in most cases being symptom-free and mostly benign, there are always malignancy risks. This study aimed to evaluate the frequency of types of thyroid nodules according to histopathology characteristics in Ahvaz hospitals.

Materials and Methods:
This retrospective cross-sectional study was performed on patients with thyroid nodules with histopathological diagnosis referred to the educational hospitals of Ahvaz Jundishapur University of Medical Sciences and private endocrine clinics in Ahvaz from 2018 to 2021. Demographic characteristics, clinical history, histopathological results, ultrasonographic findings, and the presence of lymphadenopathy were collected from the patient’s medical records.

Results:
A total of 380 patients with thyroid nodules with a mean age of 41.2 ± 12.28 years, 79.37% of whom were female were included in the study. A total of 267 (70/3%) cases were benign. Malignancy was found in 113 (29.7%) patients in which papillary thyroid cancer was the commonest histological diagnosis (n = 99; 87.61%). Age between 30 and 45 years (P = 0.001), bilateral involvement (P = 0.028), nodules size (P = 0.004), and lymph node involvement (P < 0.0001) were significantly associated with malignancy of thyroid nodules. However, there was no significant relationship between malignancy with gender (P = 0.450), BMI (P = 0.258), and history of head and neck radiotherapy (P = 0.200). There was no significant relationship between high thyroid stimulating hormone (TSH) and the type of malignancy (P = 0.059).

Conclusion:
Malignant thyroid nodules were associated with factors including age between 30 and 40 years, bilateral nodules, and lymphadenopathy. Therefore, it is important to consider these risk factors in the management and risk assessment of thyroid nodules.
A Systems Biology Approach to the Pathogenesis of Celiac Disease: Identification of Potential Protective and Promoting Mechanisms
Authors: Fadaie Mahmood , Khalafiyan Anis , Ghafouri Elham , Ranjbarnejad Tayebeh , Moein Shiva 
Published: July 2024

Background:
Celiac disease (CeD) is an autoimmune enteropathy triggered by dietary gluten. Almost 90% of CeD patients have HLA-DQ2 or -DQ8 haplotypes. As a high proportion of first-degree relatives (FDRs) of CeD patients have the same haplotype, it is assumed that they are at a higher risk of disease development than the general population. Nevertheless, the prevalence of CeD among FDRs is considerably low (7.5%).

Materials and Methods:
In order to figure out this discrepancy, a microarray dataset of intestinal mucosal biopsies of CeD patients, FDRs, and control groups was reanalyzed, and a protein-protein interaction network was constructed.

Results:
Principal component analysis showed that CeD and FDR groups are far away in terms of gene expression. Comparing differentially expressed genes of both networks demonstrated inverse expression of some genes mainly related to cell cycle mechanisms. Moreover, analysis of the modular structures of up- and downregulated gene networks determined activation of protein degradation mechanisms and inhibition of ribosome-related protein synthesis in celiac patients with an upside-down pattern in FDRs.

Conclusions:
The top-down systems biology approach determined some regulatory pathways with inverse function in CeD and FDR groups. These genes and molecular mechanisms could be a matter of investigation as potential druggable targets or prognostic markers in CeD.
Lidocaine and Dexamethasone, Ketamine and Dexamethasone, and Dexamethasone Alone in Tonsillectomy Complications
Authors: Heidari Morteza , Shetebi Hamidreza , Golshiri Parastoo , Hoghughi Somayeh 
Published: July 2024

Background:
Common complications including stridor, laryngospasm, and bronchospasm are important in patients undergoing general anesthesia. Dexamethasone, lidocaine, and ketamine could have significant roles in reducing these complications. Here we aimed to compare the use of these drugs during tonsillectomy.

Materials and Methods:
This study was performed on 100 children that were candidates of tonsillectomy. Patients were divided into 4 groups receiving dexamethasone 0.1 mg/kg and lidocaine 1 mg/kg, ketamine 0.5 mg/kg and dexamethasone 0.1 mg/kg, dexamethasone 0.1 mg/kg, and normal saline after surgical procedures. We evaluated and compared data regarding the duration of anesthesia, oxygenation saturation, blood pressure (systolic and diastolic (SBP and DBP)), re-intubation, laryngospasm, bronchospasm, requiring analgesics after surgeries, recovery stay duration, and nausea and vomiting.

Results:
Administration of ketamine and dexamethasone was associated with the lowest pain and lowest need for postoperative analgesic administrations in patients (P = 0.02). Patients that received lidocaine and dexamethasone had the lowest frequencies of airway stimulations (P < 0.001). Evaluations of complications in patients revealed that stridor was significantly lower in patients that received ketamine and dexamethasone (P = 0.01).

Conclusion:
Usage of ketamine and dexamethasone was associated with the lowest pain severities and lowest complications. On the other hand, patients that received lidocaine and dexamethasone had the least airway stimulations.
Dimethyl Fumarate Preconditioning can Reinforce the Therapeutic Potential of Bone Marrow Mesenchymal Stem Cells through Trophic Factor Profile Enhancement
Authors: Pandamooz Sareh , Safari Anahid , Ghorbani Nasrin , Jamhiri Iman , Zare Shahrokh , Belém-Filho Ivaldo Jesus Almeida , Dolati Parisa , Salehi Mohammad Saied 
Published: July 2024

Background:
Numerous studies have confirmed the therapeutic efficacy of bone marrow-derived mesenchymal stem cells (BM-MSCs) in addressing neurologic disorders. To date, several preconditioning strategies have been designed to improve the therapeutic potential of these stem cells. This study was designed to evaluate the preconditioning effect of dimethyl fumarate (DMF) on the expression of main trophic factors in human BM-MSCs.

Materials and Methods:
Initially, the identity of stem cells was confirmed through the evaluation of surface markers and their capacity for osteogenic and adipogenic differentiation using flow cytometry and differentiation assay, respectively. Subsequently, stem cells were subjected to different concentrations of DMF for 72 hours and their viability was defined by MTT assay. Following 72-hour preconditioning period with 10 µM DMF, gene expression was assessed by quantitative RT-PCR.

Results:
Our findings demonstrated that the isolated stem cells expressed cardinal MSC surface markers and exhibited osteogenic and adipogenic differentiation potential. MTT results confirmed that 10 µM DMF was an optimal dose for maintaining cell viability. Preconditioning of stem cells with DMF significantly upregulated the expression of BDNF, NGF, and NT-3. Despite a slight increase in transcript level of GDNF and VEGF after DMF preconditioning, this difference was not statistically significant.

Conclusions:
Our findings suggest that DMF preconditioning can enhance the expression of major neurotrophic factors in human BM-MSCs. Given the curative potential of both BM-MSCs and DMF in various neurological disease models and preconditioning outcomes, their combined use may synergistically enhance their neuroprotective properties.
Unveiling Potential Biomarkers for Urinary Tract Infection: An Integrated Bioinformatics Approach
Authors: Maddah Reza , Ghanbari Fahimeh , Veisi Maziyar , Koosehlar Eman , Shadpirouz Marzieh , Basharat Zarrin , Hejrati Alireza , Amiri Bahareh Shateri , Hejrati Lina 
Published: July 2024

Background:
Urinary tract infections (UTIs) are a widespread health concern with high recurrence rates and substantial economic impact, and they can increase the prevalence of antibiotic resistance. This study employed an integrated bioinformatics approach to identify key genes associated with UTI development, offering potential targets for interventions.

Materials and Methods:
For this study, the microarray dataset GSE124917 from the Gene Expression Omnibus (GEO) database was selected and reanalyzed. The differentially expressed genes (DEGs) between UTIs and healthy samples were identified using the LIMMA package in R software. In this section, Enrichr database was utilized to perform functional enrichment analysis of DEGs. Subsequently, the protein-protein interaction (PPI) network of the DEGs was constructed and visualized through Cytoscape, utilizing the STRING online database. The identification of hub genes was performed using Cytoscape’s cytoHubba plug-in employing various methods. Receiver operating characteristic (ROC) analysis was performed to assess the diagnostic accuracy of hub genes.

Results:
Among the outcomes of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the tumor necrosis factor (TNF) signaling pathway was identified as one of the notable pathways. The PPI network of the DEGs was successfully established and visualized in Cytoscape with the aid of the STRING online database. Using cytoHubba with different methods, we identified seven hub genes (STAT1, IL6, IFIT1, IFIT3, IFIH1, MX1, and IRF7). Based on the ROC analysis, all hub genes showed high diagnostic value.

Conclusion:
These findings provide a valuable baseline for future research aimed at unraveling the intricate molecular mechanisms behind UTI.
Autonomic Response Latency Revisited: Assessment of Repeatability in Healthy Subjects
Authors: Jose Annie S. , Srivastav Shival , Mehta Bharati 
Published: July 2024

Background:
Autonomic function assessment provides valuable information regarding the status of the autonomic nervous system. The time lag between the onset of orthostasis and the peak/nadir of heart rate response is a surrogate of the integrity of underlying autonomic neural pathways. Autonomic response latency (ARL) is a relatively novel yet underreported parameter in this context. Test-retest repeatability of this parameter has not been evaluated previously.

Materials and Methods:
We recruited 31 healthy adults (17 males and 14 females; 29.00 ± 5.44 years) and subjected them to postural challenge tests on five instances – forenoon and afternoon of day 1, the next day, 1 week later, and 1 month later. Tachycardia and bradycardia latencies (TL and BL) were computed using heart rate derived from digital ECG data. Repeatability was assessed using the intraclass correlation coefficient (ICC) and coefficient of variation (CoV).

Results:
ICCs for TL and BL were 0.69 (0.56, 0.82) and 0.77 (0.66, 0.87), respectively. The CoVs for TL and BL were 14.8% and 12.4%, respectively. Sex-based subgroup analysis revealed ICCs for TL and BL in males to be 0.71 (0.53, 0.86) and 0.74 (0.57, 0.88) and in females to be 0.68 (0.64, 0.86) and 0.82 (0.66, 0.93), respectively. CoVs for TL and BL were 14.4% and 13.8% in male subjects and 15.4% and 10.7% in female subjects, respectively.

Conclusion:
ARL to orthostatic challenge demonstrated moderate to good test-retest repeatability. Based on our observations, we propose that ARL has potential as a consistent and repeatable index for the assessment of the integrity of autonomic neural pathways and therefore can help in the diagnosis of autonomic neuropathy.
Assessment of Long- and Short-Term Outcomes of Hysteroscopic Polypectomy in Patients with Uterine Polyps
Authors: Hashemi Maryam , Madani Elham S. , Ghahiri Ataallah , Tarrahi Mohammad J. , Rouholamin Safoura 
Published: July 2024

Background:
Polyps are a common diagnosis in women of different ages. They can cause a variety of symptoms from bleeding to infertility and can even be the progenitor for malignancies.

Materials and Methods:
This was a retrospective cohort study conducted in Isfahan. A total of 1004 patients were included in this study. After hysteroscopic polypectomy, patients had their information regarding the complications and recurrence recorded.

Results:
Symptoms improved in 639 (63.8%). Recurrence of polyps was seen in 143 (14.2%) patients. A total of 170 had a successful pregnancy, with 110 of them spontaneous. Using scissors had lower recurrence compared to graspers. Eight cases had complications during the treatment, two of which were major.

Conclusion:
Hysteroscopic polypectomy is the treatment of choice for uterine polyps. We show hysteroscopic polypectomy to have a high success rate and a low complications rate, with polypectomies done using scissors to have lower risk of complications or recurrence compared to graspers.
Retinopathy of Prematurity (ROP)—Risk Factors and Therapeutic Effect of Intravitreal Injection of Bevacizumab (IVB): An Observational Study from a Neonatal Intensive Care Unit in Egypt
Authors: Hantash Ehab Mohamed , Al Zahrani Abdulrahman Abdullah , Serag Yasser Ragab 
Published: July 2024

Abstract

Objectives:
To study the epidemiological and demographic data of retinopathy of prematurity (ROP) as well as the effectiveness of intravitreal injection of bevacizumab (IVB) as monotherapy for type I ROP in a local neonatal intensive care unit in Egypt.

Methods:
An observational study, where the medical records of all babies eligible for ROP screening over a period of 12 months (2020–2021) were reviewed. The screening results were reported in stage, zone, extent, and plus disease. Babies with type 1 ROP were eligible for treatment with IVB. Their medical files were reviewed for possible risk factors associated with ROP. The primary outcomes were the presence or absence of ROP, eligibility for IVB, complications of IVB and regression or recurrence of ROP.

Results:
ROP affects a significant proportion of babies (55%). The lower the birth weight (and accordingly, the gestational age [GA]), the higher the incidence of ROP. Recurrent apnea, mechanical ventilation, and continuous positive airway pressure were associated with a significant risk for ROP. On the other hand, nasal cannula, sepsis, and blood transfusion did not significantly increase the risk of ROP. Although common, most cases (48.6%) had type 2 ROP and only required follow-up. IVB was effective and safe in arresting disease progression in 93% of the remaining patients with type 1 ROP (6.4%).

Conclusion:
ROP is a significant cause of morbidity in preterm babies in Egypt. Low birth weight, apnea, and respiratory support are significant risk factors. Most cases are mild and only require follow-up. Up to 6.4% of the cases had type 1 ROP. Monotherapy with IVB appears to be effective and safe. Neonatal care has to be optimized to further reduce the current incidence rate of ROP.
Vestibular rehabilitation in adults: An overview
Authors: Nocini Riccardo , Monzani Daniele , Arietti Valerio , Giacomo Papi , Segato Erika , Cornale Nicola , Lovato Andrea , Apa Enrico , Palma Silvia 
Published: July 2024

Abstract
Vertigo and dizziness are among the most common medical complaints, affecting an estimated 15%–30% of the adult population, increasing in frequency with age, and causing disability with high social costs. Over the years, the range of vestibular rehabilitation (VR) techniques available to patients has expanded from the 1940s, when Cawthorne and Cooksey observed that subjects with vestibular injuries tended to do better with exercises aimed at promoting eye and head movements in a graded manner, to today with the increasingly widespread use of virtual reality. The aim of this article is to trace the most important steps in the history of VR.