bluuebunny/crossref_metadata_2025_split huggingface dataset:
Follow-up of intracranial aneurysms treated by flow diverter: comparison of three-dimensional time-of-flight MR angiography (3D-TOF-MRA) and contrast-enhanced MR angiography (CE-MRA) sequences with digital subtraction angiography as the gold standard
Authors: Attali Jonathan , Benaissa Azzedine , Soize Sébastien , Kadziolka Krzysztof , Portefaix Christophe , Pierot Laurent 
Published: October 2014

Background and purposeFollow-up of intracranial aneurysms treated by flow diverter with MRI is complicated by imaging artifacts produced by these devices. This study compares the diagnostic accuracy of three-dimensional time-of-flight MR angiography (3D-TOF-MRA) and contrast-enhanced MRA (CE-MRA) at 3 T for the evaluation of aneurysm occlusion and parent artery patency after flow diversion treatment, with digital subtraction angiography (DSA) as the gold standard.Materials and methodsPatients treated with flow diverters between January 2009 and January 2013 followed by MRA at 3 T (3D-TOF-MRA and CE-MRA) and DSA within a 48 h period were included in a prospective single-center study. Aneurysm occlusion was assessed with full and simplified Montreal scales and parent artery patency with three-grade and two-grade scales.ResultsTwenty-two patients harboring 23 treated aneurysms were included. Interobserver agreement using simplified scales for occlusion (Montreal) and parent artery patency were higher for DSA (0.88 and 0.61) and CE-MRA (0.74 and 0.55) than for 3D-TOF-MRA (0.51 and 0.02). Intermodality agreement was higher for CE-MRA (0.88 and 0.32) than for 3D-TOF-MRA (0.59 and 0.11). CE-MRA yielded better accuracy than 3D-TOF-MRA for aneurysm remnant detection (sensitivity 83% vs 50%; specificity 100% vs 100%) and for the status of the parent artery (specificity 63% vs 32%; sensitivity 100% vs 100%).ConclusionsAt 3 T, CE-MRA is superior to 3D-TOF-MRA for the evaluation of aneurysm occlusion and parent artery patency after flow diversion treatment. However, intraluminal evaluation remains difficult with MRA regardless of the sequence used.
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53
Authors: Quigley David , Silwal-Pandit Laxmi , Dannenfelser Ruth , Langerød Anita , Vollan Hans Kristian Moen , Vaske Charles , Siegel Josie Ursini , Troyanskaya Olga , Chin Suet-Feung , Caldas Carlos , Balmain Allan , Børresen-Dale Anne-Lise , Kristensen Vessela 
Published: October 2014

Abstract
Lymphocytic infiltration is associated with better prognosis in several epithelial malignancies including breast cancer. The tumor suppressor TP53 is mutated in approximately 30% of breast adenocarcinomas, with varying frequency across molecular subtypes. In this study of 1,420 breast tumors, we tested for interaction between TP53 mutation status and tumor subtype determined by PAM50 and integrative cluster analysis. In integrative cluster 10 (IC10)/basal-like breast cancer, we identify an association between lymphocytic infiltration, determined by an expression score, and retention of wild-type TP53. The expression-derived score agreed with the degree of lymphocytic infiltration assessed by pathologic review, and application of the Nanodissect algorithm was suggestive of this infiltration being primarily of cytotoxic T lymphocytes (CTL). Elevated expression of this CTL signature was associated with longer survival in IC10/Basal-like tumors. These findings identify a new link between the TP53 pathway and the adaptive immune response in estrogen receptor (ER)–negative breast tumors, suggesting a connection between TP53 inactivation and failure of tumor immunosurveillance.
Implications: The association of lymphocytic invasion of ER-negative breast tumors with the retention of wild-type TP53 implies a novel protective connection between TP53 function and tumor immunosurveillance. Mol Cancer Res; 13(3); 493–501. ©2014 AACR.
Sensitizing B- and T- cell Lymphoma Cells to Paclitaxel/Abraxane–Induced Death by AS101 via Inhibition of the VLA-4–IL10–Survivin Axis
Authors: Danoch Hila , Kalechman Yona , Albeck Michael , Longo Dan L. , Sredni Benjamin 
Published: October 2014

AbstractCancer cell resistance to chemotherapy is a major concern in clinical oncology, resulting in increased tumor growth and decreased patient survival. Manipulation of apoptosis has emerged as a new therapeutic strategy to eliminate cancer cells. The focus of this study resides within a novel approach to target survivin, an integrator of both cell death and mitosis. This protein plays a pivotal role in the resistance of tumors to chemotherapy, especially to paclitaxel. The data herein demonstrate an indirect repression of survivin in both B- and T-cell lymphoma and human NHL by the nontoxic tellurium compound, AS101 [ammonium trichloro(dioxoethylene-o,o′)tellurate], via inhibition of tumor autocrine IL10–STAT3–Survivin signaling. As a result of survivin abrogation, sensitization of lymphomas to paclitaxel or to Abraxane, the new albumin-stabilized nanoparticle formulation of paclitaxel, occurs both in vitro and in vivo. Importantly, inhibition of lymphoma cell IL10 secretion is mediated by inactivation of the VLA-4 integrin, recently shown to be an important target of AS101. This activity is followed by inhibition of the PI3K–AKT axis that mediates IL10 suppression. Because a wide variety of lymphomas and other tumor types express VLA-4 and secrete IL10 in an autocrine manner, inhibition of survivin with a small nontoxic agent has vast clinical significance in modulating chemosensitivity in many tumor types.Implications: Combination therapy with AS101 and paclitaxel has novel therapeutic potential targeting deregulated active pathways in lymphoma, overcoming endogenous resistance to apoptosis. Mol Cancer Res; 13(3); 411–22. ©2014 AACR.
Comparing the Ambulatory Care and Outcomes for Rural and Urban Patients With Chronic Ischemic Heart Disease
Authors: Tran Christopher , Wijeysundera Harindra C. , Qui Feng , Tu Jack V. , Bhatia R. Sacha 
Published: October 2014

Background—
Little is known about variations in the quality of ambulatory care between urban and rural communities for patients with stable ischemic heart disease. The objectives of this study were to understand the effect of rurality on variations of ambulatory processes of care and outcomes for patients with stable ischemic heart disease.

Methods and Results—

A population-based cohort study was conducted, which included all Ontario patients with stable ischemic heart disease confirmed on cardiac catheterization between October 1, 2008, and September 30, 2011. Patients were categorized as rural or urban based on the Rurality Index for Ontario score. Ambulatory processes of care of interest were diagnostic testing, medication usage, and access to general/speciality physicians over a 1-year time-horizon. Primary outcome was 1-year mortality. Secondary outcomes included 1-year myocardial infarction, repeat cardiac/all-cause hospitalization, and emergency department visits. The cohort consisted of 38 804 patients, of whom 34 949 (90%) were urban and 3855 (10%) were rural patients. After risk-adjustment, rural patients had lower rates of cholesterol assessment (odds ratios 0.41; 95% confidence interval [CI], 0.38–0.44;
P
<0.001), hemoglobin A1C assessment (odds ratios 0.41; 95% CI, 0.38–0.44;
P
<0.001), and statin use (odds ratios 0.67; 95% CI, 0.57–0.79;
P
<0.001) compared with urban patients. Rural patients had fewer total ambulatory physician visits (rate ratio 0.76; 95% CI, 0.75–0.78;
P
<0.001)), primary care (0.76; 95% CI, 0.74–0.78;
P
<0.001), and cardiology visits (0.71; 95% CI, 0.68–0.74;
P
<0.001) over 1 year. Emergency department utilization was higher among rural patients (odds ratios 1.82; 95% CI, 1.70–1.96;
P
<0.001), but myocardial infarction, hospitalization, and mortality rates were similar.

Conclusions—
Despite variation in ambulatory processes of care between urban and rural patients with stable ischemic heart disease, there were no outcome differences.
Polygenic Overlap Between Kidney Function and Large Artery Atherosclerotic Stroke
Authors: Holliday Elizabeth G. , Traylor Matthew , Malik Rainer , Bevan Stephen , Maguire Jane , Koblar Simon A. , Sturm Jonathan , Hankey Graeme J. , Oldmeadow Christopher , McEvoy Mark , Sudlow Cathie , Rothwell Peter M. , Coresh Josef , Hamet Pavel , Tremblay Johanne , Turner Stephen T. , de Andrade Mariza , Rao Madhumathi , Schmidt Reinhold , Crick Peter A. , Robino Antonietta , Peralta Carmen A. , Jukema J. Wouter , Mitchell Paul , Rosas Sylvia E. , Wang Jie Jin , Scott Rodney J. , Dichgans Martin , Mitchell Braxton D. , Kao W.H. Linda , Fox Caroline S. , Levi Christopher , Attia John , Markus Hugh S. 
Published: October 2014

Background and Purpose—
Epidemiological studies show strong associations between kidney dysfunction and risk of ischemic stroke (IS), the mechanisms of which are incompletely understood. We investigated whether these associations may reflect shared heritability because of a common polygenic basis and whether this differed for IS subtypes.

Methods—

Polygenic models were derived using genome-wide association studies meta-analysis results for 3 kidney traits: estimated glomerular filtration rate using serum creatinine (eGFRcrea: n=73 998), eGFR using cystatin C (eGFRcys: n=22 937), and urinary albumin to creatinine ratio (n=31 580). For each, single nucleotide polymorphisms passing 10
P
value thresholds were used to form profile scores in 4561 IS cases and 7094 controls from the United Kingdom, Germany, and Australia. Scores were tested for association with IS and its 3 aetiological subtypes: large artery atherosclerosis, cardioembolism, and small vessel disease.

Results—

Polygenic scores correlating with higher eGFRcrea were associated with reduced risk of large artery atherosclerosis, with 5 scores reaching
P
<0.05 (peak
P
=0.004) and all showing the epidemiologically expected direction of effect. A similar pattern was observed for polygenic scores reflecting higher urinary albumin to creatinine ratio, of which 3 associated with large artery atherosclerosis (peak
P
=0.01) and all showed the expected directional association. One urinary albumin to creatinine ratio–based score also associated with small vessel disease (
P
=0.03). The global pattern of results was unlikely to have occurred by chance (
P
=0.02).

Conclusions—
This study suggests possible polygenic correlation between renal dysfunction and IS. The shared genetic components may be specific to stroke subtypes, particularly large artery atherosclerotic stroke. Further study of the genetic relationships between these disorders seems merited.
Simple Text-Messaging Intervention Is Associated With Improved Door-to-Needle Times for Acute Ischemic Stroke
Authors: Burnett Molly M. , Zimmermann Lara , Coralic Zlatan , Quon Tina , Whetstone William , Kim Anthony S. 
Published: October 2014

Background and Purpose—
Timely administration of intravenous tissue-type plasminogen activator (IV tPA) is associated with improved outcomes for acute ischemic stroke; yet, developing processes to consistently provide prompt treatment remains a challenge. We developed and evaluated a simple quality improvement intervention designed to improve door-to-needle (DTN) times for resident-led Code Stroke teams at an academic medical center.

Methods—
We evaluated a simple text-messaging based intervention with real-time feedback to improve DTN times for intravenous tissue-type plasminogen activator. We used the rank-sum test and linear regression to evaluate for a change in DTN times that was temporally associated with the rollout of the intervention.

Results—

A total of 202 patients received intravenous tissue-type plasminogen activator; 94 preintervention and 108 postintervention. The median DTN time was significantly lower in the postintervention period (56 minutes [interquartile range 44–71] versus 82 minutes [IQR 68–103],
P
<0.0001) and a significantly higher proportion of patients were treated within 60 minutes (61% versus 16%,
P
<0.001).

Conclusions—
A simple real-time text-messaging intervention was associated with a significant improvements in DTN times for acute ischemic stroke.
A combined cryo-scanning electron microscopy/cryoplaning approach to study the infection of Meloidogyne incognita eggs by Pochonia chlamydosporia
Authors: Manzanilla-López Rosa H. , Devonshire Jean , Ward Elaine , Hirsch Penny R. 
Published: October 2014

The fungus Pochonia chlamydosporia is a saprophytic soil-dwelling fungus and is also a parasite of the eggs of the root-knot plant-parasitic nematodes (Meloidogyne spp.). Studies on its molecular characterisation, diversity, tritrophic interactions and ecology have been carried out. However, to elucidate the role in soil and rhizosphere ecology of this and other nematophagous fungi used in biological control, and to enhance their exploitation, it is necessary to improve the understanding of the biology and fungus-nematode infection process using different approaches, including microscopy. Low-temperature Scanning Electron Microscopy (cryo-SEM) techniques allow the examination of frozen, fully hydrated samples that can reveal important ultrastructural features occurring through fungus-nematode interactions. A method that combined cryo-SEM with cryoplaning was developed to examine samples of eggs, gelatinous matrix and females of Meloidogyne incognita colonised by P. chlamydosporia. The fungal samples were produced in potato dextrose agar to which different nematode stages were added and processed for cryo-SEM and cryoplaning within a period of 0-72 h post inoculation. The method was found to be rapid and economical, provided clear and detailed external images of the infection process and allowed viewing of sections through structures with minimal processing in comparison to other cryo-SEM techniques and it could be adapted to study other fungus-nematode interactions.
The types, publication date, and validity of Nucella elongata Golikov &amp; Kussakin (Mollusca, Ocenebrinae)
Authors: CHICHVARKHIN ANTON , CHICHVARKHINA OLGA 
Published: October 2014

The name Nucella heyseana var. elongata Golikov & Kussakin, 1962 was proposed for a ‘form of uncertain taxonomic level’, found in Kunashir and Sakhalin islands. However, this entity was previously recorded as Thais lamellosa (non Gmelin, 1791) (Kussakin 1956: 105–106, 108). In this description, the individual collected from southern shore of Kunashir Island was verbally described in the text and illustrated with a photographic image (Golikov & Kussakin 1962: 312–315, pl. 2, fig. 2c [‘в’ in Russian]). N. heyseana var. elongata was expressly proposed as an infrasubspecific entity, as a variation of N. heyseana (Dunker, 1882) specific to particular habitats. Therefore it is not an available name according the provisions of International Code of Zoological Nomenclature Articles 45.5 and 45.6.3 (ICZN 1999; hereafter the Code). According to Article 1.3.4 it should be excluded from the species group as not regulated by the Code. In 1974, Golikov & Kussakin described this form as the species Nucella elongata Golikov and Kussakin, 1962, mentioning the same entity (Golikov & Kussakin 1974: 295). This verbal description is identical with their previous text published in 1962, although the new species was not illustrated. However, the same specimen from Kunashir Island was clearly designated as the holotype repeating the same shell measurements and collecting location. In this and following publications N. elongata was reported from Kurile Islands and Sakhalin (Golikov & Kussakin 1978: 190–191, fig. 132; Golikov & Scarlato 1985: 426). In 1978, they repeated their texts dated 1962 and 1974 confirming the same specimen from Kunashir Island as the holotype preserved in Zoological Institute, Russian Academy of Sciences, St. Petersburg (ZIN) collection, although they illustrated different shell (presumably a paratype, which we did not find in ZIN) obtained from southeastern Sakhalin.
„Sublokatorka” po latach. Z Hanną Krall rozmawiają Elżbieta Janicka i Joanna Tokarska-Bakir. Warszawa, 28 lutego i 8 marca 2013 roku
Authors: Krall Hanna , Janicka Elżbieta , Tokarska-Bakir Joanna 
Published: October 2014

"Sublokatorka" now. An interview with Hanna Krall: Warsaw, 28 February and 28 March 2013The interview was conducted by Elżbieta Janicka and Joanna Tokarska-Bakir. Hanna Krall told the story of the issues related to the publication of Sublokatorka, which finally appeared in the Paris-based printing house Libella, owned by Zofia and Kazimierz Romanowicz, in 1985. Hanna Krall also spoke about how the book was received by the public in the unofficial underground discourse in the Communist Poland. Moreover, the author of Sublokatorka told the interviewers about the construction of stories about the Holocaust, as well as about the people who inspired the protagonists of Sublokatorka: Luba Bielicka-Blum, Rywka Urman, Krystyna Krahelska, Krzysztof Kieślowski and Jerzy Stuhr. „Sublokatorka” po latach. Z Hanną Krall rozmawiają Elżbieta Janicka i Joanna Tokarska-Bakir. Warszawa, 28 lutego i 8 marca 2013 rokuHanna Krall opowiada Elżbiecie Janickiej i Joannie Tokarskiej-Bakir o kłopotach z publikacją Sublokatorki, która ostatecznie ukazała się w paryskim wydawnictwie Zofii i Kazimierza Romanowiczów Libella w 1985 roku. Tematem rozmowy jest także burzliwy, niewolny od werbalnej agresji, odbiór książki w drugim, niezależnym obiegu kultury w PRL. W wywiadzie mowa ponadto o sposobach konstruowania i stawkach opowieści o Zagładzie, a także o pierwowzorach postaci z Sublokatorki takich jak: Luba Bielicka-Blum, Rywka Urman, Krystyna Krahelska, Krzysztof Kieślowski czy Jerzy Stuhr.
Validating Atmospheric Reanalysis Data using Tropical Cyclones as Thermometers
Authors: Kossin James P. 
Published: October 2014

Abstract
Temperatures in the upper troposphere of the atmosphere, near the tropopause, play a key role in the evolution of tropical cyclones (TC) by controlling their potential intensity (PI), which describes the thermodynamically based maximum TC intensity that the environment will support. Accurately identifying past trends in PI is critical for understanding the causes of observed changes in TC intensity, but calculations of PI trends using different atmospheric reanalysis products can give very different results, largely due to differences in their representation of upper-tropospheric temperatures. Without a means to verify the fidelity of the upper-tropospheric temperatures, PI trends calculated from these products are very uncertain.
Here, a method is introduced to validate the upper-tropospheric temperatures in the reanalysis products by using the TCs themselves as thermometers. Using a 30-yr global dataset of TC cloud-top temperatures and three widely utilized atmospheric reanalysis products—Modern-Era Retrospective Analysis for Research and Applications (MERRA), ECMWF interim reanalysis (ERA-Interim), and NCEP–NCAR Global Reanalysis 1—it is shown that storm-local upper-level temperatures in the MERRA and ERA-Interim data vary similarly to the TC cloud-top temperatures on both interannual and decadal time scales, but the NCEP–NCAR data have substantial biases that introduce an increasing trend in storm-local PI not found in the other two products. The lack of global storm-local PI trends is due to a balance between temporal increases in the mean state and the poleward migration of TCs into lower climatological PI, and it has significant implications for the detection and attribution of mean TC intensity trends.
Global Lightning Parameterization from CMIP5 Climate Model Output
Authors: Magi Brian I. 
Published: October 2014

AbstractLightning is best known as a component of severe weather, but diverse communities of researchers, such as those in atmospheric chemistry and global fire modeling, have long recognized that lightning plays a significant role in many components of the Earth system. Global climate models are unlikely to be able to simulate lightning from first principles, but the same models do simulate many parameters related to convection, including total precipitation rate, convective precipitation rate, and convective mass flux. This study combines satellite observations of lightning and CMIP5 climate model simulations to derive an empirical parameterization of monthly lightning in terms of monthly simulated convective parameters. Convective mass flux best captures the spatiotemporal distribution of observed lightning. Derived lightning seasonality is captured with 95% confidence over 69% of land but only 30% of ocean. Spatially, the correlation of derived lightning and observed lightning is 0.74. Overall, global observations suggest lightning occurs at an annual rate of 47 flashes per second, while lightning from the parameterization occurs at 44 flashes per second. A robust feature of the relationship between lightning and climate model convective parameters is that lightning flash rate increases linearly with increases in convective precipitation rate and in convective mass flux for a significant subset of the total range of those convective parameters. Namely, this linear proportionality is evident when the convective precipitation rate is less than 4–5 mm day−1 and the convective mass flux is less than 15–16 kg m−2 h−1, which account for about 90% of the values simulated by the climate models.
Upscale Error Growth in a High-Resolution Simulation of a Summertime Weather Event over Europe*
Authors: Selz Tobias , Craig George C. 
Published: October 2014

Abstract
The growth of small-amplitude, spatially uncorrelated perturbations has been studied in a weather forecast of a 4-day period in the summer of 2007, using a large domain covering Europe and the eastern Atlantic and with explicitly resolved deep convection. The error growth follows the three-stage conceptual model of Zhang et al., with rapid initial growth (e-folding time about 0.5 h) on all scales, relaxing over about 20 h to a slow growth of the large-scale perturbations (e-folding time 12 h). The initial growth was confined to precipitating regions, with a faster growth rate where conditional instability was large. Growth in these regions saturated within 3–10 h, continuing for the longest where the precipitation rate was large. While the initial growth was mainly in the divergent part of the flow, the eventual slow growth on large scales was more in the rotational component.
Spectral decomposition of the disturbance energy showed that the rapid growth in precipitating regions projected onto all Fourier components; however, the amplitude at saturation was too small to initiate the subsequent large-scale growth. Visualization of the disturbance energy showed it to expand outward from the precipitating regions at a speed corresponding to a deep tropospheric gravity wave. These results suggest a physical picture of error growth with a rapidly growing disturbance to the vertical mass transport in precipitating regions that spreads to the radius of deformation while undergoing geostrophic adjustment, eventually creating a balanced perturbation that continues to grow through baroclinic instability.
Familial tumoral calcinosis
Authors: Alkhatib Amal , Burton Laura E , Carachi Robert 
Published: October 2014

Introduction Tumoral calcinosis is a rare condition characterised by progressive, ectopic, periarticular deposits of calcium. These tumour-like growths often infiltrate muscle and tendon, usually presenting as multiple masses or as a painless, solitary mass. Our case report will focus on familial tumoral calcinosis, an autosomal recessive metabolic disorder generally observed in patients within the first two decades of life. Case presentation Our case report introduces two Sudanese siblings from consanguineous parents who presented with simultaneous recurrent multiple soft tissue swellings. Conclusion The cases discussed highlight the main features of familial tumoral calcinosis and indicate the need for improved clinical guidance on the investigations, treatment and genetic screening of familial tumoral calcinosis.