bluuebunny/crossref_metadata_2025_split huggingface dataset:
Full Mouth Rehabilitation of a Patient with Severely Worn Dentition and Reduced Occlusal Vertical Dimension: A Clinical Report
Authors: Muley Bipin Yeshwantrao , Khalikar Arun N , Shaikh Sameera Rafique , Tagore Mohana M , Wankhade Sattyam V 
Published: June 2013

ABSTRACT
Esthetic and functional rehabilitation of severely worn dentition presents a significant challenge to the restorative dentist. The prerequisites in restoring the worn dentition are to understand the determinants of the occlusal vertical dimension and the effects of its alteration on the temporomandibular joint, muscle comfort, bite force, speech and long-term occlusal stability. This clinical report describes a sequential treatment procedure of full mouth rehabilitation of a patient with severe attrition and cervical abrasion of teeth with metal-ceramic restorations and implant supported fixed dental prosthesis after establishing a functional and esthetic vertical dimension and occlusal plane.

How to cite this article
Muley BY, Khalikar AN, Shaikh SR, Tagore MM, Patil PG, Wankhade SV. Full Mouth Rehabilitation of a Patient with Severely Worn Dentition and Reduced Occlusal Vertical Dimension: A Clinical Report. Int J Prosthodont Restor Dent 2012;2(2):72-76.
ZnO Nanoparticles Applied to Bioimaging and Drug Delivery
Authors: Xiong Huan‐Ming 
Published: June 2013

AbstractThe last decade has seen significant achievements in biomedical diagnosis and therapy at the levels of cells and molecules. Nanoparticles with luminescent or magnetic properties are used as detection probes and drug carriers, both in vitro and in vivo. ZnO nanoparticles, due to their good biocompatibility and low cost, have shown promising potential in bioimaging and drug delivery. The recent exciting progress on the biomedical applications of ZnO‐based nanomaterials is reviewed here, along with discussions on the advantages and limitations of these advanced materials and suggestions for improving methods.
Beryllium disease among construction trade workers at department of Energy nuclear sites
Authors: Welch Laura S. , Ringen Knut , Dement John , Bingham Eula , Quinn Patricia , Shorter Janet , Fisher Miles 
Published: June 2013

AbstractBackgroundA medical surveillance program was developed to identify current and former construction workers at significant risk for beryllium related disease from work at the DOE nuclear weapons facilities, and to improve surveillance among beryllium exposed workers.MethodsMedical examinations included a medical history and a beryllium blood lymphocyte proliferation test (BeLPT). Stratified and multivariate logistic regression analyses were used to explore the risk of disease by age, race, trade, and reported work in buildings where beryllium was used. After adjusting for covariates, the risk of BeS was significantly higher among boilermakers, roofers, and sheet metal workers, as suggested in the stratified analyses. Workers identified as sensitized to beryllium were interviewed to determine whether they had been subsequently diagnosed with chronic beryllium disease.ResultsBetween 1998 and December 31, 2010 13,810 workers received a BeLPT through the BTMed program; 189 (1.4%) were sensitized to beryllium, and 28 reported that they had had a compensation claim accepted for CBD.ConclusionsThese data on former construction workers gives us additional information about the predictive value of the blood BeLPT test for detection of CBD in populations with lower total lifetime exposures and more remote exposures than that experienced by current workers in beryllium machining operations. Through this surveillance program we have identified routes of exposures to beryllium and worked with DOE site personnel to identity and mitigate those exposures which still exist, as well as helping to focus attention on the risk for beryllium exposure among current demolition workers at these facilities. Am. J. Ind. Med. 56:1125–1136, 2013. © 2013 Wiley Periodicals, Inc.
QTc interval and electrocardiographic changes by type of shift work
Authors: Meloni Michele , Setzu Davide , Del Rio Alberto , Campagna Marcello , Cocco Pierluigi 
Published: June 2013

AbstractBackgroundWe conducted a cross sectional survey of electrocardiographic changes among shift‐workers.MethodsWe classified the electrocardiogram morphology, and measured the QTc interval in 91 male workers engaged in regular daily work‐shifts, 32 in 24 hr work‐shift (h24), and 93 in irregular 6 hr work‐shift (h6).ResultsWith reference to daily workers, the QTc interval was prolonged among h6 workers (P < 0.001) and h24 workers (P < 0.005). The age‐ and obesity‐adjusted standardized prevalence ratio (SPR) of a borderline/prolonged QTc was 2.2‐fold among h6 workers (95% CI 1.2, 4.2); conduction disorders (SPR = 2.6; 95% CI 1.3, 5.2) and repolarization disorders (SPR = 1.9; 95% CI 1.0, 3.5) were also more frequently observed among h6 workers. Excluding 19 subjects with risk factors for prolonged QTc did not change the results.ConclusionsOur study reveals significant changes in the ECG morphology in relation to shift‐work, especially in unpredictable and non‐standard working hours. Am. J. Ind. Med. 56:1174–1179, 2013. © 2013 Wiley Periodicals, Inc.
Electrochemical Magnetoimmunosensing Approach for the Sensitive Detection of H9N2 Avian Influenza Virus Particles
Authors: Zhou Chuan‐Hua , Shu Yun , Hong Zheng‐Yuan , Pang Dai‐Wen , Zhang Zhi‐Ling 
Published: June 2013

AbstractA novel electrochemical magnetoimmunosensor for fast and ultrasensitive detection of H9N2 avian influenza virus particles (H9N2 AIV) was designed based on the combination of high‐efficiency immunomagnetic separation, enzyme catalytic amplification, and the biotin–streptavidin system. The reusable, homemade magneto Au electrode (M‐AuE) was designed and used for the direct sensing. Immunocomplex‐coated magnetic beads (IMBs) were easily accumulated on the surface of the M‐AuE to obtain the catalytically reduced electrochemical signal of H2O2 after the immunoreaction. The transducer was regenerated through a simple washing procedure, which made it possible to detect all the samples on a single electrode with higher reproducibility. The magnetic‐bead‐based electrochemical immunosensor showed better analytical performance than the planar‐electrode‐based immunosensor with the same sandwich construction. Amounts as low as 10 pg mL−1 H9N2 AIV could be detected even in samples of chicken dung. This electrochemical magnetoimmunosensor not only provides a simple platform for the detection of the virus with high sensitivity, selectivity, and reproducibility but also shows great potential in the early diagnosis of diseases.
Two Unusual 3D POM‐Ag Frameworks with Tetragonal and Dodecagonal Helical Channels
Authors: Sha Jingquan , Li Mengting , Sun Jingwen , Yan Pengfei , Li Guangming , Zhang Lei 
Published: June 2013

AbstractTwo new hybrid compounds with tetragonal and dodecagonal helical channels, K[Ag14(pyttz)4(H2O)2][PW12O40]2⋅(OH)⋅5 H2O (1) and K[Ag14(pyttz)4(H2O)4][HSiW12O40]2⋅H2O (2), have been hydrothermally synthesized and structurally characterized by using routine techniques. X‐ray diffraction analysis shows that compounds 1 and 2 are isostructural and crystallize in the monoclinic space group P21/c. A fascinating structural feature of these compounds is that they form 3D POM‐Ag frameworks with helical channels, which are the first examples of helical channels that are constructed from POMs and metal atoms. Notably, there are two types of spatial orientation of the POMs, which result in the formations of left‐ and right‐handed helical chains. Furthermore, these different helical chains are perfectly enclosed through shared POMs, thereby forming tetragonal and dodecagonal helical channels. In addition, the photocatalytic degradation of RhB by these compounds was also investigated.
Using sound to represent uncertainty in UKCP09 data with Google Maps API
Authors: Bearman Nick , Jones Phil , Lovett Andrew 
Published: June 2013

AbstractThe UK Climate Projections 2009 (UKCP09) dataset contains future climate projections for the UK and a measure of uncertainty for these values. Understanding both types of data is important for scientific interpretation, but just presenting information visually has limitations because of the amount of data involved. This study evaluates the use of sound to represent uncertainty using a survey tool developed with Google Maps API (Application Programming Interface) (n = 72). Use of sound to reinforce visual information results in significantly better performance for participants (p = 0.006), and participants also performed more effectively with pre‐existing knowledge of the dataset and with practice.
What is the relationship between China summer precipitation and the change of apparent heat source over the Tibetan Plateau?
Authors: Xu Xiangde , Lu Chungu , Ding Yihui , Shi Xiaohui , Guo Yudi , Zhu Wenhui 
Published: June 2013

AbstractIt is well documented that the East Asian summer monsoon has been experiencing a steady weakening trend in recent decades. Because the Asian summer monsoon (including both East Asian monsoon and South Asian monsoon) is the largest and most pronounced monsoonal system in the world, its change in strength may exert a profound impact on global weather and climate systems, especially on the rainfall pattern in South and East Asia. On the other hand, as a vast elevated landmass, the Tibetan Plateau forms a huge heat source protruding into the free atmosphere. Setting against the backdrop of global climate change, whether or not does the change of this heating affect the change of Asian summer monsoon and thus rainfall distribution? Here we show that the apparent heat source over the Tibetan Plateau is closely correlated with the East Asian summer monsoonal circulation, and that the weakening of the East Asian summer monsoon is closely associated with the decreasing trend of the Tibetan Plateau apparent heat source. Further analysis indicates that the change of rainfall pattern in China in recent decades is consistent with the decreasing of the East Asian summer monsoon.
Review and comparison of ROC curve estimators for a time‐dependent outcome with marker‐dependent censoring
Authors: Blanche Paul , Dartigues Jean‐François , Jacqmin‐Gadda Hélène 
Published: June 2013

To quantify the ability of a marker to predict the onset of a clinical outcome in the future, time‐dependent estimators of sensitivity, specificity, and ROC curve have been proposed accounting for censoring of the outcome. In this paper, we review these estimators, recall their assumptions about the censoring mechanism and highlight their relationships and properties. A simulation study shows that marker‐dependent censoring can lead to important biases for the ROC estimators not adapted to this case. A slight modification of the inverse probability of censoring weighting estimators proposed by Uno et al. (2007) and Hung and Chiang (2010a) performs as well as the nearest neighbor estimator of Heagerty et al. (2000) in the simulation study and has interesting practical properties. Finally, the estimators were used to evaluate abilities of a marker combining age and a cognitive test to predict dementia in the elderly. Data were obtained from the French PAQUID cohort. The censoring appears clearly marker‐dependent leading to appreciable differences between ROC curves estimated with the different methods.
ZnS quantum dots‐based fluorescence spectroscopic technique for the detection of quercetin
Authors: Wu Dudu , Chen Zhi 
Published: June 2013

ABSTRACTWater‐soluble ZnS quantum dots (QDs) modified by mercaptoacetic acid (MPA) were used to determinate quercetin in aqueous solutions by a fluorescence spectroscopic technique. The results showed that the fluorescence of the modified ZnS QDs could be quenched by quercetin effectively in physiological buffer solution. The optimum fluorescence intensity was found to be at incubation time 10 min, pH 7.0 and temperature 25°C. Under the optimal conditions, the detection limit of quercetin was 5.71 × 10‐7 mol/L. Moreover, the quenching mechanism was discussed to be a static quenching procedure, which was proved by the quenching rate constant Kq (1.14 × 1013 L/mol/s). Copyright © 2013 John Wiley & Sons, Ltd. Copyright © 2013 John Wiley & Sons, Ltd.
PEG chain length impacts yield of solid‐phase protein PEGylation and efficiency of PEGylated protein separation by ion‐exchange chromatography: Insights of mechanistic models
Authors: Yoshimoto Noriko , Isakari Yu , Itoh Daisuke , Yamamoto Shuichi 
Published: June 2013

AbstractThe mechanisms behind protein PEGylation are complex and dictated by the structure of the protein reactant. Hence, it is difficult to design a reaction process which can produce the desired PEGylated form at high yield. Likewise, efficient purification processes following protein PEGylation must be constructed on an ad hoc basis for each product. The retention and binding mechanisms driving electrostatic interaction‐based chromatography (ion‐exchange chromatography) of PEGylated proteins (randomly PEGylated lysozyme and mono‐PEGylated bovine serum albumin) were investigated, based on our previously developed model Chem. Eng. Technol. 2005, 28, 1387–1393. PEGylation of each protein resulted in a shift to a smaller elution volume compared to the unmodified molecule, but did not affect the number of binding sites appreciably. The shift of the retention volume of PEGylated proteins correlated with the calculated thickness of PEG layer around the protein molecule. Random PEGylation was carried out on a column (solid‐phase PEGylation) and the PEGylated proteins were separated on the same column. Solid‐phase PEGylation inhibited the production of multi‐PEGylated forms and resulted in a relatively low yield of selective mono‐PEGylated form. Pore diffusion may play an important role in solid‐phase PEGylation. These results suggest the possibility of a reaction and purification process development based on the mechanistic model for PEGylated proteins on ion exchange chromatography.
Computational protein design with electrostatic focusing: Experimental characterization of a conditionally folded helical domain with a reduced amino acid alphabet
Authors: Suárez‐Diez Maria , Pujol Anaïs M. , Matzapetakis Manolis , Jaramillo Alfonso , Iranzo Olga 
Published: June 2013

AbstractAutomated methodologies to design synthetic proteins from first principles use energy computations to estimate the ability of the sequences to adopt a targeted structure. This approach is still far from systematically producing native‐like sequences, due, most likely, to inaccuracies when modeling the interactions between the protein and its aqueous environment. This is particularly challenging when engineering small protein domains (with less polar pair interactions than with the solvent). We have re‐designed a three‐helix bundle, domain B, using a fixed backbone and a four amino acid alphabet. We have enlarged the rotamer library with conformers that increase the weight of electrostatic interactions within the design process without altering the energy function used to compute the folding free energy. Our synthetic sequences show less than 15% similarity to any Swissprot sequence. We have characterized our sequences in different solvents using circular dichroism and nuclear magnetic resonance. The targeted structure achieved is dependent on the solvent used. This method can be readily extended to larger domains. Our method will be useful for the engineering of proteins that become active only in a given solvent and for designing proteins in the context of hydrophobic solvents, an important fraction of the situations in the cell.
Development and validation of a liquid chromatography–tandem mass spectrometry method for topotecan determination in beagle dog plasma and its application in a bioequivalence study
Authors: Ye Ling , Shi Jian , Wan Shanhe , Yang Xiaoshan , Wang Ying , Zhang Jiajie , Zheng Dayong , Liu Zhongqiu 
Published: June 2013

ABSTRACTTopotecan (TPT) is an important anti‐cancer drug that inhibits topoisomerase I. A sensitive and robust liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method that potentially determines TPT in beagle dog plasma is needed for a bioequivalence study of TPT formulations. We developed and validated LC‐MS/MS to evaluate TPT in beagle dog plasma in terms of specificity, linearity, precision, accuracy, stability, extraction recovery and matrix effect. Plasma samples were treated with an OstroTM sorbent plate (a robust and effective tool) to eliminate phospholipids and proteins before analysis. TPT and camptothecin (internal standard) were separated on an Acquity UPLC BEH C18 column (1.7 µm, 2.1 × 50 mm) with 0.1% formic acid and methanol as the mobile phase at a flow rate of 0.25 mL/min. TPT was analyzed using positive ion electrospray ionization in multiple‐reaction monitoring mode. The obtained lower limit of quantitation was 1 ng/mL (signal‐to‐noise ratio > 10). The standard calibration curve for TPT was linear (correlation coefficient > 0.99) at the concentration range of 1–400 ng/mL. The intra‐day and inter‐day precision, accuracy, stability, extraction recovery and matrix effect of TPT were within the acceptable limits. The validated method was successfully applied in a bioequivalence study of TPT in healthy beagle dogs. Copyright © 2013 John Wiley & Sons, Ltd.
Turning healthcare challenges into big data opportunities: A use‐case review across the pharmaceutical development lifecycle
Authors: Schultz Timothy 
Published: June 2013

AbstractEditor's SummaryIn order to draw meaning from the exponentially increasing quantity of healthcare data, it must be dealt with from a big data perspective, using technologies capable of processing massive amounts of data efficiently and securely. The pharmaceutical industry faces the big data challenge through all phases of the drug development lifecycle. Genomics, clinical monitoring and pharmacovigilance illustrate the value of a big data approach. Whether focusing on genetic and environmental disease risks, pattern detection through real time biosensors for patients or post‐market monitoring of drug effectiveness, each area involves the collection and analysis of numerous variables and requires extreme computing power to reveal the details of interplay between the variables. To make big data work for pharmaceutical information, attention must be paid to data collection on a vast scale, from multiple sites and over long time periods. Big data support must be incorporated into interoperable electronic medical records and presented intuitively through visual analytics.
Visioning studies in emergency health care to support R&D of new technologies
Authors: Sonnenwald Diane H. 
Published: June 2013

AbstractEditor's SummaryGiven the risk and cost of proposed but unproven technologies, a method to project likely outcomes offers great value. Visioning studies deliver that opportunity by enabling potential users and other stakeholders the chance to explore new technologies. Goals include validating benefits, exposing unanticipated consequences, discovering hurdles to deployment and revealing considerations for funding. A visioning study was used to investigate 3D telepresence technology in emergency health care, enabling paramedics to work on a simulated trauma victim along with a remote physician. In another phase of the study, three groups of stakeholders viewed a brief video on the proposed technology and were interviewed to understand their thoughts on advantages, obstacles and potential fit. Through the visioning study, researchers were able to explore implementation of the technology and experience its potential benefits and challenges in a realistic test mode. Knowledge gained through visioning can lead to better‐informed decisions and more effective use of limited resources.
‘What's Going On’ to Safeguard Children and Young People from Child Sexual Exploitation: A Review of Local Safeguarding Children Boards’ Work to Protect Children from Sexual Exploitation
Authors: Pearce Jenny J. 
Published: June 2013

This article draws on findings from research into the implementation by local safeguarding children boards (local government multi‐agency panels responsible for child protection in England) of national guidance on safeguarding children from child sexual exploitation (CSE). Despite there being some excellent examples of practice, a lack of awareness of the issues faced by sexually exploited children or a lack of resources to address them meant that only a quarter were implementing the dual aim of the guidance: protecting children and prosecuting abusers. The research developed a data monitoring tool, its use showing that children experiencing CSE had multiple problems, many already receiving support from a range of service providers for other related problems. This suggests that there might be scope for better early identification and prevention of CSE. The research showed new forms of CSE, including peer‐on‐peer sexual exploitation, raising important questions about engaging with children who were both perpetrators and victims of abuse. Finally, research findings identified methods of disrupting and prosecuting abusers, giving insight into some of the complexities involved in achieving both. In the main, safeguarding children was best facilitated through co‐located multi‐agency teams where child protection and law enforcement practitioners worked together. Copyright © 2013 John Wiley & Sons, Ltd.‘There might be scope for better early identification and prevention of CSE’Key Practitioner Messages:

Local safeguarding children boards have a key responsibility to protect children from sexual exploitation and disrupt and prosecute abusers.
Sexually exploited children experience a range of different problems, and are often known to service providers who need better training to respond to the abuse.
Exploitation is changing, including peer‐on‐peer sexual violence.
Protection can be achieved through co‐located multi‐agency teams supported by direct service provision to young people.
Development of Mesoscopically Assembled Sulfated Zirconia Nanoparticles as Promising Heterogeneous and Recyclable Biodiesel Catalysts
Authors: Das Swapan K. , El‐Safty Sherif A. 
Published: June 2013

AbstractThe nanoassembly of nearly monodisperse nanoparticles (NPs) as uniform building blocks to engineer zirconia (ZrO2) nanostructures with mesoscopic ordering by using a template as a fastening agent was explored. The mesophase of the materials was investigated through powder X‐ray diffraction and TEM analysis (TEM) and N2 sorption studies. The TEM results revealed that the mesopores were created by the arrangement of ZrO2 NPs with sizes of 7.0–9.0 nm and with broad interparticle pores. Moreover, the N2 sorption study confirmed the results. The surface chemical analysis was performed to estimate the distribution of Zr, O, and S in the sulfated ZrO2 matrices. The materials in this study displayed excellent catalytic activity in the biodiesel reaction for effective conversion of long‐chain fatty acids to their methyl esters, and the maximum biodiesel yield was approximately 100 %. The excellent heterogeneous catalytic activity could be attributed to the open framework, large surface area, presence of ample acidic sites located at the surface of the matrix, and high structural stability of the materials. The catalysts revealed a negligible loss of activity in the catalytic recycles.