bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma Adiponectin Levels for Prediction of Cardiovascular Risk Among Hemodialysis Patients
Authors: El‐Shafey Eid M , Shalan Mohamed 
Published: July 2013

AbstractAdiponectin (ADPN) is an endogenous insulin sensitizing and anti‐inflammatory hormone, released by the adipose tissue. We investigated the clinical and biochemical correlates of plasma ADPN levels and the predictive value of ADPN with respect to survival rates and cardiovascular (CV) events was tested prospectively in a cohort of hemodialysis (HD) patients. We measured baseline ADPN in 110 HD patients, in addition to, 34 healthy subjects to serve as reference group. ADPN levels, were related to different clinical and biochemical cardiovascular risk factors such as increased body mass index (BMI), serum triglycerides (TG), duration of HD, smoking, mean arterial blood pressure (MBP), heart rate (HR), high density (HDL) cholesterol, low density (LDL) cholesterol, serum glucose, hemoglobulin and C‐reactive protein (CRP) levels in HD patients. Plasma ADPN levels were higher (P = 0.000) among HD patients (15.06 ± 3.54 μg/mL) than among reference subjects (6.52 ± 1.07 μg/mL), were independent of age, and higher among women (16.13 ± 3.09 μg/mL) than among men (13.94 ± 3.65 μg/mL). Plasma ADPN levels were inversely related to BMI, TG, CRP and glucose levels. Furthermore, plasma ADPN levels were directly related to HDL‐cholesterol and Kt/V. Plasma ADPN levels were lower (P = 0.000) among patients who experienced new CV events (11.13 ± 2.15 μg/mL) than among event‐free patients (16.82 ± 2.45 μg/mL), and seem to predict cardiovascular outcomes. The inverse relationships between ADPN and several cardiovascular risk factors indicate that ADPN may have a protective role in the prevention of CV events.
Mixing of Isaria fumosorosea with enhanced diatomaceous earth and bitterbarkomycin for control of Rhyzopertha dominica
Authors: Riasat Tahira , Wakil Waqas , Yasin Muhammad , Kwon Yong Jung 
Published: July 2013

AbstractThe virulence of Isaria fumosorosea alone and integrated with an enhanced formulation of diatomaceous earth (diatomaceous earth + bitterbarkomycin, DEBBM) was tested against the lesser grain borer Rhyzopertha dominica (F.) (Coleoptera: Bostrychidae) under laboratory conditions on stored wheat. The fungus was applied to wheat grains at various concentrations of 3.60 × 106, 3.60 × 108, and 3.60 × 1010 conidia/kg alone, or in combination with 15 and 30 ppm of DEBBM. R. dominica was held at 20, 25 and 30°C and two RH regimes (56 and 75%) and mortality was registered after 5, 10 and 15 d. Generally, I. fumosorosea was most effective at 25°C caused the highest mortality of R. dominica at 56% RH. The increase of temperature, concentration and exposure interval increased the insecticidal effect of DEBBM at low RH level. The DE alone suppressed the progeny emergence at higher dose rate as compared I. fumosorosea alone, but their simultaneous use further reduced the progeny production of R. dominica. The integrated use of both tested bio control agents synergized the effect of each other and caused the highest mortality at 25°C and 56% RH. The results clearly demonstrated that I. fumosorosea and new enhanced DEBBM can be integrated to be an effective control measure for R. dominica in stored wheat.
A systematic review of attachment and psychosis: measurement, construct validity and outcomes
Authors: Gumley A. I. , Taylor H. E. F. , Schwannauer M. , MacBeth A. 
Published: July 2013

ObjectiveThis review sought to identify, summarise and critically evaluate studies that investigated attachment amongst individuals with psychosis.MethodThe following computerised databases searched were CINAHL < 1980 to December 2012; EMBASE < 1980 to December 2012; Ovid MEDLINE (R) < 1980 to December 2012; PsychINFO < 1980 to December 2012; and Google Scholar < 1980 to December 2012.ResultsWe identified 22 papers describing 21 studies comprising 1453 participants, with a mean age of 35.0 years (range of 12–71 years), of whom 68.4% (n = 994) were male. Of our sample, 1112 (76.5%) had a diagnosis of schizophrenia. We found small to moderate associations between greater attachment insecurity (as reflected in anxiety and avoidance) and poorer engagement with services, more interpersonal problems, more avoidant coping strategies, more negative appraisals of parenting experiences and more severe trauma. We also found small to modest associations between attachment insecurity and more positive and negative symptoms and greater affective symptom problems.ConclusionAttachment theory may be useful as a means of understanding the developmental and interpersonal basis of recovery and adaptation in the context of psychosis. However, further research comprising more representative samples in their first episode and using prospective designs is required.
Extracorporeal Detoxification for Hepatic Failure Using Molecular Adsorbent Recirculating System: Depurative Efficiency and Clinical Results in a Long‐Term Follow‐Up
Authors: Donati Gabriele , La Manna Gaetano , Cianciolo Giuseppe , Grandinetti Valeria , Carretta Elisa , Cappuccilli Maria , Panicali Laura , Iorio Mario , Piscaglia Fabio , Bolondi Luigi , Colì Luigi , Stefoni Sergio 
Published: July 2013

AbstractAcute liver failure and acute‐on‐chronic liver failure still show a poor prognosis. The molecular adsorbent recirculating system (MARS) has been extensively used as the most promising detoxifying therapy for patients with these conditions. Sixty‐four patients with life‐threatening liver failure were selected, and 269 MARS treatments were carried out as a bridge for orthotopic liver transplantation (OLT) or for liver function recovery. All patients were grouped according to the aim of MARS therapy. Group A consisted of 47 patients treated for liver function recovery (median age 59 years, range 23–82). Group B consisted of 11 patients on the waiting list who underwent OLT (median age 47 years, range 32–62). Group C consisted of 6 patients on the waiting list who did not undergo OLT (median age 45.5 years, range 36–54, P = 0.001). MARS depurative efficiency in terms of liver toxins, cytokines, and growth factors was assessed together with the clinical outcome of the patients during a 1‐year follow‐up. Total bilirubin reduction rate per session (RRs) for each MARS session was 23% (range 17–29); direct bilirubin RRs was 28% (21–35), and indirect bilirubin RRs was 8% (3–21). Ammonia RRs was 34% (12–86). Conjugated cholic acid RRs was 58% (48–61); chenodeoxycholic acid RRs was 34% (18–48). No differences were found between groups. Hepatocyte growth factor (HGF) values on starting MARS were 4.1 ng/mL (1.9–7.9) versus 7.9 ng/mL (3.2–14.1) at MARS end (P < 0.01). Cox regression analysis to determine the risk factors predicting patient outcomes showed that age, male gender, and Sequential Organ Failure Assessment score (but not Model for End‐stage Liver Disease score) were factors predicting death, whereas the number of MARS sessions and the ΔHGF proved protective factors. Kaplan–Meier survival analysis was also used; after 12 months, 21.3% of patients in Group A survived, while 90.9% were alive in Group B and 16.7% in Group C (log rank = 0.002). In conclusion, MARS was clinically well tolerated by all patients and significantly reduced hepatic toxins. Better survival rates were linked to an OLT program, but patients' clinical characteristics on starting MARS therapy were the main factors predicting survival. The role of HGF should be evaluated in larger clinical trials.
Economic evaluation of bariatric surgery to combat morbid obesity: A study from the West of Scotland
Authors: Karim Muhammad Ali , Clifton Edward , Ahmed Jamil , Mackay Gordon William , Ali Abdulmajid 
Published: July 2013

AbstractIntroductionThe increasing prevalence of obesity has now become a global concern. Forecasts of its health and financial ramifications have prompted the need for effective interventions. Bariatric surgery is an effective measure to control obesity and its related comorbidities, but its high upfront costs have raised questions about its cost‐effectiveness. In this study we evaluated the health care‐related direct cost savings after bariatric surgery.MethodsData were prospectively obtained from patients who underwent bariatric surgery between May 2008 and April 2011, and a review was performed. These patients' annual cost of regular medications, hospital admissions and outpatient clinic visits were compared with the postoperative costs of these services. Data were collected from January 2005 to April 2012.ResultsThe analysis included 88 patients, 17 of whom were men and 71 were women. The procedures included 36 laparoscopic adjustable gastric banding, 33 sleeve gastrectomies and 19 Roux‐en‐Y gastric bypasses. All procedures were laparoscopic. Data were collected from patients during a median preoperative period of 60 months (range, 42–75 months) and a median postoperative period of 24 months (range, 12–45 moths). Annual savings were £11 452 on medications, £16 420 on hospital admissions and £2532 on outpatient clinic visits. Total annual savings were £30 404.ConclusionGiven the rising prevalence of morbid obesity, bariatric surgery is a cost‐effective treatment for morbid obesity and should be made available to morbidly obese patients.
An analysis of a decade of research in 10 instructional design and technology journals
Authors: West Richard Edward , Borup Jered 
Published: July 2013

AbstractIn this paper, we review findings from an analysis of the past decade (2001–10) of research in 10 major journals in the field of instructional design and technology. Each research paper published in these journals during this decade was categorized according to its focus or methodology, topical keywords, authorship and citation trends; and the findings were aggregated across all of the journals to show trends over the last decade. We found there is a strong emphasis on technology‐related issues, distance education, communication strategies and instructional methods over cognitive‐related topics and learning issues. There is a strong history of theoretical inquiry and a fairly even balance of qualitative and quantitative research being published, with other research methods emerging. However, there are distinct differences in methodological stances among the journals. We also found some evidence that the Institute for Scientific Information Impact Factor may not be the best indicator of impact quality for journals in our field.
Late Ordovician, deep‐water gravity‐flow deposits, palaeogeography and tectonic setting, Tarim Basin, Northwest China
Authors: Lin C. , Liu J. , Eriksson K. , Yang H. , Cai Z. , Li H. , Yang Z. , Rui Z. 
Published: July 2013

AbstractThe Upper Ordovician in the Tarim Basin contains 5000–7000 m of siliciclastic and calciclastic deep‐water, gravity‐flow deposits. Their depositional architecture and palaeogeographical setting are documented in this investigation based on an integrated analysis of seismic, borehole and outcrop data. Six gravity‐flow depositional–palaeogeomorphological elements have been identified as follows: submarine canyon or deeply incised channels, broad and shallow erosional channels, erosional–depositional channel and levee–overbank complexes, frontal splays‐lobes and nonchannelized sheets, calciclastic lower slope fans and channel lobes or sheets, and debris‐flow complexes. Gravity‐flow deposits of the Sangtamu and Tierekeawati formations comprise a regional transgressive‐regressive megacycle, which can be further classified into six sequences bounded by unconformities and their correlative conformities. A series of incised valleys or canyons and erosional–depositional channels are identifiable along the major sequence boundaries which might have been formed as the result of global sea‐level falls. The depositional architecture of sequences varies from the upper slope to abyssal basin plain. Palaeogeographical patterns and distribution of the gravity‐flow deposits in the basin can be related to the change in tectonic setting from a passive continental margin in the Cambrian and Early to Middle Ordovician to a retroarc foreland setting in the Late Ordovician. More than 3000 m of siliciclastic submarine‐fan deposits accumulated in south‐eastern Tangguzibasi and north‐eastern Manjiaer depressions. Sedimentary units thin onto intrabasinal palaeotopographical highs of forebulge origin and thicken into backbulge depocentres. Sediments were sourced predominantly from arc terranes in the south‐east and the north‐east. Slide and mass‐transport complexes and a series of debris‐flow and turbidite deposits developed along the toes of unstable slopes on the margins of the deep‐water basins. Turbidite sandstones of channel‐fill and frontal‐splay origin and turbidite lobes comprise potential stratigraphic hydrocarbon reservoirs in the basin.
Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis
Authors: Wisniewski J. A. , Agrawal R. , Minnicozzi S. , Xin W. , Patrie J. , Heymann P. W. , Workman L. , Platts‐Mills T. A. , Song T. W. , Moloney M. , Woodfolk J. A. 
Published: July 2013

SummaryBackgroundAtopic dermatitis (AD) is common in children; however, persistence of AD with or without asthma is less common. Longitudinal studies remain limited in their ability to characterize how IgE antibody responses evolve in AD, and their relationship with asthma.ObjectiveTo use a cross‐sectional study design of children with active AD to analyse age‐related differences in IgE antibodies and relation to wheeze.MethodsIgE antibodies to food and inhalant allergens were measured in children with active AD (5 months to 15 years of age, n = 66), with and without history of wheeze.ResultsWhereas IgE antibodies to foods persisted at a similar prevalence and titre throughout childhood, IgE antibodies to all aeroallergens rose sharply into adolescence. From birth, the chance of sensitization for any aeroallergen increased for each 12‐month increment in age (OR ≥ 1.21, P < 0.01), with the largest effect observed for dust mite (OR = 1.56, P < 0.001). A steeper age‐related rise in IgE antibody titre to dust mite, but no other allergen was associated with more severe disease. Despite this, sensitization to cat was more strongly associated with wheeze (OR = 4.5, P < 0.01), and linked to Fel d 1 and Fel d 4, but not Fel d 2. Comparison of cat allergic children with AD to those without, revealed higher IgE levels to Fel d 2 and Fel d 4 (P < 0.05), but not Fel d 1.Conclusions and Clinical RelevanceDifferences in sensitization to cat and dust mite among young children with AD may aid in identifying those at increased risk for disease progression and development of asthma. Early sensitization to cat and risk for wheeze among children with AD may be linked to an increased risk for sensitization to a broader spectrum of allergen components from early life. Collectively, our findings argue for early intervention strategies designed to mitigate skin inflammation in children with AD.
Thromboembolism during neoadjuvant therapy for rectal cancer: a systematic review
Authors: Smart P. J. , Burbury K. L. , Lynch A. C. , Mackay J. R. , Heriot A. G. 
Published: July 2013

AbstractAimThromboembolism (TE) is a common, costly and morbid complication that is also associated with decreased survival in cancer patients. However, the risk of cancer‐associated TE varies because of the multitude of patient‐, cancer‐ and treatment‐related influences. Thromboprophylaxis (TP) is currently not widely adopted in the ambulant population. A review of the literature was undertaken to determine the rate of TE and the benefit of TP in patients with rectal cancer during neoadjuvant therapy (nT).MethodA systematic literature search of electronic databases, including PubMed and Embase, was performed (1995–2012) for all studies assessing nT in rectal cancer. Data were extracted and used to assess study design, patient demographic and clinical characteristics, treatment protocols and TE incidence. A systematic review was conducted to identify the rates of TE. The search strategy included text terms and MeSH headings for TP, rectal cancer and nT.ResultsTwelve of 86 studies met quality criteria for reporting TE complications and described 10 pulmonary emboli and three deep‐vein thromboses in 3375 patients (overall TE rate = 0.38%). Ninety per cent of pulmonary emboli reported were fatal, suggesting significant under‐reporting of TE events, even in high‐quality studies.ConclusionThe risk of fatal pulmonary embolism in studies examining nT in rectal cancer that reported complications systematically was one in 375 (0.27%; 95% CI: 0.09–0.44%). The overall TE rate, as well as the effectiveness of TP during nT, remains unknown. TE events should be systematically reported using common terminology frameworks in cancer studies.
Spawning movements of humpback whitefish in interiorAlaska rivers
Authors: Dupuis Aaron W. , Sutton Trent M. 
Published: July 2013

AbstractThis study was conducted to describe the spawning movements and identify spawning areas for humpback whitefishCoregonus pidschianin theMintoFlats–ChatanikaRiver complex,Alaska, during 2008 and 2009. Radio transmitters were surgically implanted in humpback whitefish in 2008 (N = 60) and 2009 (N = 100), and fish positions were determined through a combination of boat and aerial surveys and fixed receiving stations. Two spawning areas were identified: one in theChatanikaRiver downstream of theElliotHighwayBridge and the other in theTananaRiver nearFairbanks. Humpback whitefish dispersed from the wetland complex ofMintoFlats inJune, moved upstream through lateAugust, arrived at the spawning areas in earlySeptember and began moving downstream in earlyOctober. In 2009, spatially segregated movements were observed when approximately 40% of the radio‐tagged humpback whitefish moved to theTananaRiver, suggesting that humpback whitefish inMintoFlats are comprised of mixed spawning stocks. These study results provide a complete account of humpback whitefish movements and their associated spawning habitats, which will allow for better‐informed management strategies.
Cerebrospinal fluid biomarkers of neurodegeneration in patients with juvenile and classic myotonic dystrophy type 1
Authors: Peric S. , Mandic‐Stojmenovic G. , Markovic I. , Stefanova E. , Ilic V. , Parojcic A. , Misirlic‐Dencic S. , Ostojic M. , Rakocevic‐Stojanovic V. , Kostic V. 
Published: July 2013

Background and purposeThe aim of the present study was to analyze cerebrospinal fluid (CSF) levels of total tau (T‐tau), phosphorylated tau (P‐tau) and the 42‐amino‐acid form of β‐amyloid (Aβ42) in patients with myotonic dystrophy type 1 (DM1), and their possible correlations with cognitive and behavioral manifestations in these patients.MethodsLumbar puncture was performed in 74 patients with DM1 [27 with the childhood/juvenile form (jDM1) and 47 with the adult form (aDM1) of the disease] and 26 control subjects who were subjected to orthopedic surgery. Sandwich ELISA was used for measuring the levels of T‐tau, P‐tau and Aβ42.ResultsThe CSF level of Aβ42 was at its lowest in patients with jDM1 and at its highest in controls (P < 0.05). A tendency of T‐tau and P‐tau to increase was greater in aDM1 patients than in jDM1 patients and controls (P > 0.05). In both jDM1 and aDM1 patients, significant correlations were found between Aβ42 and T‐tau (rho = 0.81 and rho = 0.67, respectively, P < 0.01), as well as between Aβ42 and P‐tau (rho = 0.87 and rho = 0.67, respectively, P < 0.01). The Aβ42/P‐tau ratio decreased with age in aDM1 patients (rho = −0.30, P < 0.05). Only the level of Aβ42 in the CSF of jDM1 patients was correlated with the size of the CTG expansion (rho = −0.53, P < 0.05). Only a few correlations were observed between levels of biomarkers and neuropsychological testing.ConclusionThe CSF level of Aβ42 was decreased in patients with jDM1, whilst the Aβ42/P‐tau ratio was decreased in aDM1 patients. Positive correlations between Aβ42, T‐tau and P‐tau were observed in both forms of disease. Further studies with larger cohorts of DM1 patients are necessary.
The unique N‐terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1
Authors: Goel Raghuveera K. , Miah Sayem , Black Kristin , Kalra Natasha , Dai Chenlu , Lukong Kiven E. 
Published: July 2013

SRMS (Src‐related tyrosine kinase lacking C‐terminal regulatory tyrosine and N‐terminal myristoylation sites) belongs to a family of nonreceptor tyrosine kinases, which also includes breast tumour kinase and Fyn‐related kinase. SRMS, similar to breast tumour kinase and Fyn‐related kinase, harbours a Src homology 3 and Src homology 2, as well as a protein kinase domain. However, unlike breast tumour kinase and Fyn‐related kinase, SRMS lacks a C‐terminal regulatory tail but distinctively possesses an extended N‐terminal region. Both breast tumour kinase and Fyn‐related kinase play opposing roles in cell proliferation and signalling. SRMS, however, is an understudied member of this family. Although cloned in 1994, information on the biochemical, cellular and physiological roles of SRMS remains unreported. The present study is the first to explore the expression pattern of SRMS in breast cancers, its enzymatic activity and autoregulatory elements, and the characterization of docking protein 1 as its first bonafide substrate. We found that, similar to breast tumour kinase, SRMS is highly expressed in most breast cancers compared to normal mammary cell lines and tissues. We generated a series of SRMS point and deletion mutants and assessed enzymatic activity, subcellular localization and substrate recognition. We report for the first time that ectopically‐expressed SRMS is constitutively active and that its N‐terminal region regulates the enzymatic activity of the protein. Finally, we present evidence indicating that docking protein 1 is a direct substrate of SRMS. Our data demonstrate that, unlike members of the Src family, the enzymatic activity of SRMS is regulated by the intramolecular interactions involving the N‐terminus of the enzyme and that docking protein 1 is a bona fide substrate of SRMS.Structured digital abstract

SRMS physically interacts with Dok-1 by pull down (View Interaction: 1, 2)

Dok-1 physically interacts with SRMS by anti bait coimmunoprecipitation (View Interaction: 1, 2, 3)

SRMS phosphorylates Dok-1 by protein kinase assay (View interaction)

Dok-1 physically interacts with SRMS by anti tag coimmunoprecipitation (View interaction)