bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative drug delivery methods for combating antimicrobial resistance
Authors: Ejike Innocent Nwankwo  , Ebube Victor Emeihe  , Mojeed Dayo Ajegbile  , Janet Aderonke Olaboye  , Chukwudi Cosmos Maha  
Published: August 2024

Antimicrobial resistance (AMR) poses a significant threat to global health, complicating the treatment of infectious diseases and leading to increased morbidity and mortality. Innovative drug delivery methods are emerging as critical strategies to combat AMR by enhancing the efficacy of existing antibiotics and facilitating the development of new therapeutic approaches. This paper explores the role of novel drug delivery systems in addressing AMR challenges. One of the primary approaches is the development of targeted drug delivery systems that improve the precision of antibiotic therapy. Nanotechnology has revolutionized this field, enabling the creation of nanoparticles and nanocarriers that can deliver drugs directly to infection sites, reducing systemic side effects and enhancing drug concentration at the target. These advanced delivery systems can be engineered to release antibiotics in a controlled manner, overcoming bacterial resistance mechanisms and minimizing the likelihood of resistance development. Another promising strategy involves the use of combination therapies delivered through innovative methods. By combining antibiotics with adjuvants or resistance-modifying agents, these systems can counteract resistance mechanisms and restore the effectiveness of existing drugs. For instance, drug delivery platforms that co-deliver antibiotics with inhibitors of bacterial efflux pumps or biofilm formation can enhance the treatment of resistant infections. The integration of smart drug delivery systems, which respond to environmental stimuli such as pH changes or specific bacterial enzymes, offers additional advantages. These systems can release antibiotics only in the presence of resistant bacteria, thereby reducing the overall exposure of bacteria to antibiotics and decreasing the risk of resistance. Innovative drug delivery methods also include the development of long-acting formulations and implants that provide sustained release of antibiotics over extended periods. Such systems reduce the frequency of dosing, improve patient adherence, and ensure consistent therapeutic levels, which are crucial for managing chronic infections and preventing resistance. In conclusion, innovative drug delivery methods are pivotal in the fight against AMR. By enhancing drug targeting, combining therapies, and utilizing smart and sustained-release systems, these approaches offer promising solutions to improve antibiotic efficacy and curb resistance. Continued research and development in this area are essential for advancing therapeutic strategies and ensuring effective management of infectious diseases in the face of rising antimicrobial resistance.
Keywords: Innovative, Drug Delivery Methods, Combating, Antimicrobial, Resistance.
Artificial intelligence in predictive analytics for epidemic outbreaks in rural populations
Authors: Geneva Tamunobarafiri Igwama  , Ejike Innocent Nwankwo  , Ebube Victor Emeihe  , Mojeed Dayo Ajegbile  
Published: August 2024

Artificial Intelligence (AI) is revolutionizing the approach to managing epidemic outbreaks, especially in rural populations where resources are often limited. This paper discusses the role of AI in predictive analytics for epidemic forecasting and response in these underserved areas. AI-driven predictive models utilize advanced algorithms and large datasets to anticipate outbreaks, identify potential hotspots, and optimize resource allocation. AI applications in predictive analytics integrate various data sources, including historical health records, real-time surveillance data, and environmental factors, to create accurate epidemic forecasts. These models enhance the ability to predict the spread of diseases by identifying patterns and correlations that traditional methods might miss. For rural areas, where data collection and health monitoring can be challenging, AI offers a crucial advantage by providing actionable insights from limited and disparate data sources. One notable application is the use of machine learning algorithms to analyze patterns of disease transmission and predict future outbreaks. These models can forecast the likelihood of disease spread based on current trends and historical data, enabling timely intervention and preparedness. For instance, AI has been used to predict flu outbreaks by analyzing historical flu data combined with social media trends and environmental factors. Moreover, AI-driven predictive analytics facilitate more efficient allocation of healthcare resources by forecasting demand for medical supplies and personnel. This is particularly valuable in rural settings where healthcare infrastructure is often sparse. By predicting areas at high risk for outbreaks, AI helps prioritize interventions and deploy resources where they are needed most. However, the application of AI in rural epidemic management faces challenges, including data quality issues, the need for robust local data infrastructure, and ensuring equitable access to technological advancements. Addressing these challenges is crucial for maximizing the impact of AI in improving epidemic preparedness and response in rural populations. In conclusion, AI in predictive analytics holds significant promise for enhancing epidemic management in rural areas by providing timely, data-driven insights that improve forecasting and resource allocation. Future advancements in AI and improvements in data infrastructure will further strengthen these capabilities, ultimately leading to better health outcomes in underserved communities.
Keywords: AI, Predictive Analytics, Epidemic Outbreak, Rural, Populations.
Vertical variability of aerosol properties and trace gases over a remote marine region: a case study over Bermuda
Authors: Ajayi Taiwo , Choi Yonghoon , Crosbie Ewan C. , DiGangi Joshua P. , Diskin Glenn S. , Fenn Marta A. , Ferrare Richard A. , Hair Johnathan W. , Hilario Miguel Ricardo A. , Hostetler Chris A. , Kirschler Simon , Moore Richard H. , Shingler Taylor J. , Shook Michael A. , Soloff Cassidy , Thornhill Kenneth L. , Voigt Christiane , Winstead Edward L. , Ziemba Luke D. , Sorooshian Armin 
Published: August 2024

Abstract. Remote marine regions comprise a high fraction of Earth's surface, but in situ vertically resolved measurements over these locations remain scarce. Here we use airborne data during 15 vertical spiral soundings (0.15–8.5 km) over Bermuda during the NASA Aerosol Cloud meTeorology Interactions over the western ATlantic Experiment (ACTIVATE) to investigate the impact of different source regions on the vertical structure of trace gases, aerosol particles, and meteorological variables over 1000 km offshore of the US East Coast. Results reveal significant differences in vertical profiles of variables between three different air mass source categories (North America, Ocean, Caribbean/North Africa) identified using the Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model: (i) the strongest pollution signature is from air masses from the North America category, while the weakest one is from the Ocean category; (ii) North America air has the highest levels of CO, CH4, submicron particle number concentration, aerosol mass spectrometer (AMS) mass, and organic mass fraction along with smoke layers in the free troposphere (FT); (iii) Ocean air has the highest relative amount of nitrate, non-sea-salt sulfate, and oxalate, which are key acidic species participating in chloride depletion; (iv) air masses from the Caribbean/North Africa showed a pronounced coarse aerosol signature in the FT and reduced aerosol hygroscopicity, which is associated with dust transport; and (v) there is considerable vertical heterogeneity for almost all variables examined, including higher O3 and submicron particle concentrations with altitude, suggesting that the FT is a potential contributor of both constituents in the marine boundary layer. This study highlights the importance of considering air mass source origin and vertical resolution to capture aerosol and trace gas properties over remote marine areas.
PENINGKATAN HASIL BELAJAR PENDIDIKAN PANCASILA MELALUI MEDIA PANILA (PAPAN PENERAPAN NILAI-NILAI PANCASILA) PADA SISWA KELAS V SD NEGERI KOTA MALANG
Authors: Helmi Citra , Hariani Lilik Sri , Rukmini Choiriyah 
Published: August 2024

Salah satu pendidikan yang sangat penting dalam membentuk karakter yaitu pendidikan Pancasila. Penelitian ini bertujuan untuk meningkatkan hasil belajar Pendidikan Pancasila pada siswa Kelas V di SDN Kota Malang melalui penerapan media PANILA (Papan Penerapan Nilai-Nilai Pancasila) dengan menggunakan metode penelitian tindakan kelas (PTK) berbasis Problem Based Learning. Metode penelitian ini menggunakan desain PTK yang melibatkan dua siklus pembelajaran yang dilakukan dalam pre-test, dan 2 siklus, masing-masing siklus terdiri dari 1 pertemuan untuk melihat hasil dari peningkatan aktivitas belajar siswa melalui media (PANILA) dengan subjek penelitian berjumlah 27 siswa. Penggunaan Media PANILA dan model Problem Based Learning dapat menjadi alternatif yang bermanfaat dalam meningkatkan pemahaman siswa tentang nilai-nilai Pancasila dan mengintegrasikannya dalam kehidupan sehari-hari mereka. Hasil penelitian menunjukkan bahwa penerapan media PANILA dengan model Problem Based Learning dapat meningkatkan hasil belajar Pendidikan Pancasila pada siswa Kelas V SD Negeri Kota Malang. Pada pre-test ketuntasan nilai siswa sebesar 25,92%, siklus I siswa yang mendapatkan nilai ketuntasan sebesar 62,96%, Sedangkan pada pembelajaran siklus II siswa yang mendapatkan nilai ketuntasan sebesar 80,19%. Kesimpulan yang dapat diambil dari penelitian ini adalah penggunaan Media PANILA dapat meningkatkan hasil belajar siswa pada pembelajaran Pendidikan Pancasila di kelas V SDN Kota Malang.
INTERDISPLINER NOVEL BIDADARI BERMATA BENING KARYA HABIBURRAHMAN EL SHIRAZY DENGAN KITAB ALALA LIRBOYO KARYA AL ZARNUJI
Authors: Mubarok Muhammad Kholil , Marzuqi Iib 
Published: August 2024

Tujuan penelitian ini adalah untuk mengetahui 1) perbedaan nilai-nilai akhlak yang terdapat dalam Novel Bidadari Bermata Bening karya Habiburrahman El Shirazy dengan Kitab Alala Lirboyo karya Al Zarnuji, dan 2) persamaan nilai-nilai akhlak yang terdapat dalam Novel Bidadari Bermata Bening karya Habiburrahman El Shirazy dengan Kitab Alala Lirboyo karya Al Zarnuji. Penelitian ini termasuk penelitian yang bersifat kualitatif deskriptif. Adapun dalam pengumpulan datanya menggunakan teknik simak dan catat. Kemudian data yang dianalisis oleh peneliti menggunakan metode human instrumen (peneliti sendiri).
ANALISIS RISIKO PADA PROYEK PEMBANGUNAN JALAN TOL (STUDI KASUS PROYEK PEMBANGUNAN JALAN TOL TERBANGGI BESAR – PEMATANG PANGGANG – KAYU AGUNG)
Authors: Simanjuntak Manlian Ronald A , Putra Fisika Prasetyo , Hidayat Taufiq 
Published: August 2024

Di dalam pembangunan proyek konstruksi jalan tol selalu memiliki banyak risiko yang berpotensi menghambat kinerja proyek secara keseluruhan hingga menimbulkan kerugian terhadap biaya, mutu, waktu pelaksanaan hingga reputasi perusahaan.. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisa risiko yang berpengaruh, paling dominan serta kepemilikannya pada proyek pembangunan jalan tol Terbanggi Besar - Pematang Panggang - Kayu Agung yang merupakan jalan tol terpanjang di Indonesia (189 km) dan berada di dua provinsi dengan mayoritas berjenis tanah rawa atau lahan gambut. Kuisioner survei merupakan tahap awal dalam pengumpulan data untuk memperoleh variabel penelitian dengan melakukan validasi pakar, kemudian disebar kepada 89 responden untuk dilakukan analisa dan penilaian tingkat risiko. Kepemilikan dan mitigasi risiko didapatkan dari hasil analisa penulis maupun wawancara dengan pakar. Hasil penelitian ini menunjukkan terdapat 71 variabel risiko yang berpengaruh pada proyek pembangunan jalan tol Terbanggi Besar-Pematang Panggang-Kayu Agung. Sumber risiko dengan tingkat risiko ekstrim paling banyak yaitu keuangan dengan 6 variabel, alami dengan 4 variabel dan proyek dengan 4 variabel. Sumber risiko yang tidak memiliki risiko ekstrim adalah kriminal dan keselamatan. Kepemilikan risiko terbanyak dimiliki oleh kontraktor sebanyak 27 risiko, dimiliki pemilik proyek (owner) sebanyak 8 risiko dan dimiliki konsultan sebanyak 5 risiko. Hal ini karena kontraktor mempunyai tanggung jawab terbesar pada tahap pelaksanaan proyek, sedangkan pemilik proyek dan konsultan merupakan pihak yang mendukung untuk percepatan penyelesaian proyek. Kata kunci: risiko, konstruksi, jalan tok, mitigasi
A resistência do peregrino João Luiz Pozzobon
Authors: Rosa Borin Marta 
Published: August 2024

Quando, no século XIX, os imigrantes europeus aportaram no Brasil, os que eram católicos depararam-se com um catolicismo popular que se desenvolvia de forma autóctone, mesclando influências da administração da coroa portuguesa e depois pela brasileira, que controlavam o clero e o usavam para fins de dominação. A falta de padres propiciou a reunião de leigos em irmandades, nas quais se desenvolveu um catolicismo devocional que não carecia de sacerdote. Ainda, no século XIX, com a romanização, a Igreja católica voltou-se contra esse tipo de profissão de fé, mas o povo, em contrapartida, permaneceu resistente e continuou a cultivar práticas religiosa já enraizadas pela tradição.
A literatura e as "baixas vozes"
Authors: Biroli Flávia 
Published: August 2024

Este trabalho discute comparativamente textos ficcionais e historiográficos, enfocando sua relação com um período específico, os anos 60 e 70, no Brasil. A partir de contos do escritor Ivan Ângelo e de um artigo do historiador Thomas Skidmore, analisamos os modos particulares de negociação com a heterogeneidade constitutiva nos textos, isto é, o modo como as histórias narradas "deixam falar" e o m odo como definem " a quem é permitido falar", assim como os efeitos concretos dessa negociação nas relações que os discursos historiográfico e ficcional estabelecem com o poder, a verdade e o cotidiano. Realizada a análise, concluímos o trabalho como uma breve reflexão sobre o uso didático dos discursos historiográfico e ficcional.
Analisis Perspektif Konsultan Pajak dalam Menanggapi Surat Permintaan Penjelasan atas Data dan/atau Keterangan pada Rumah Sakit X Klien SAR Tax & Management Consultant
Authors: Nadeak Anisyah Putri , Devano Sony 
Published: August 2024

Peraturan perpajakan yang berlaku, termasuk peraturan daerah memerlukan perhatian khusus dari pihak manajemen Rumah Sakit X dan profesional pajak yang terlibat. Instrumen perpajakan yang kerap menjadi sorotan dalam konteks Rumah Sakit X adalah Surat Permintaan Penjelasan Atas Data dan/atau Keterangan (SP2DK). SP2DK bertujuan untuk memperoleh informasi tambahan tentang kepemilikan aset, pendapatan, dan kewajiban pajak Wajib Pajak. Penelitian ini bertujuan untuk menganalisis perspektif Konsultan Pajak dalam menanggapi Surat Permintaan Penjelasan atas Data dan/atau Keterangan (SP2DK) yang diterima oleh Rumah Sakit X. Penelitian ini menggunakan metode pendekatan kualitatif. Data dikumpulkan melalui wawancara mendalam dengan Konsultan Pajak yang berpengalaman dalam menangani kasus SP2DK pada Rumah Sakit X. Dalam penelitian ini, digunakan data primer dan data sekunder. Data primer diperoleh dari hasil wawancara triangulasi sehingga terbentuk penelitian yang netral, sedangkan data sekunder didapatkan dari jurnal, artikel, buku, dan penelitian terdahulu terkait. Penelitian dilakukan di SAR Tax & Management Consultant, Bandung. Hasil penelitian menunjukkan bahwa Konsultan Pajak menghadapi sejumlah tantangan dalam menanggapi SP2DK pada Rumah Sakit X, termasuk kurangnya keteraturan dan kelengkapan dokumentasi, kompleksitas aturan perpajakan yang berlaku, keterbatasan waktu dalam penyampaian SP2DK, serta kendala dalam komunikasi antara Konsultan Pajak dan pihak klien Rumah Sakit X. Namun, Konsultan Pajak juga menyoroti pentingnya keterbukaan, kerjasama, dan kesadaran pajak yang tinggi dari pihak Rumah Sakit X dalam menyelesaikan SP2DK dengan baik. Juga tidak terdapat perbedaan dalam proses menanggapi SP2DK antara organisasi sektor publik dan sektor bisnis, yang membedakan hanya pada sisi objek pajak yang dikenakannya.
Manajemen Sarana dan Prasarana untuk Meningkatkan Mutu dalam Pembelajaran
Authors: MZ Yusuf 
Published: August 2024

Penelitian ini bertujuan untuk: (1) mendeskripsikan perencanaan sarana dan prasarana di Madrasah Aliyyah Pembangunan (MAP.) Plus Ketrampilan Mandirancan Kuningan, (2) mendeskripsikan pengadaan sarana dan prasarana di Madrasah Aliyah Pembangunan (MAP.) Plus Ketrampilan Mandirancan Kuningan (3) mendeskripsikan penggunaan sarana dan prasarana di Madrasah Aliyyah Pembangunan (MAP.) Plus Ketrampilan Mandirancan Kuningan (4) mendeskripsikan penghapusan sarana dan prasarana di Madrasah Aliyah Pembangunan (MAP.) Plus Ketrampilan Mandirancan Kuningan. Penelitian ini menggunakan metode penelitian kualitatif, dan rancangan dalam penelitian ini menggunakan studi kasus. Hasil penelitian ini menunjukkan bahwa, perencanaan sarana dan prasarana di sekolah ini dilakukan melalui Wakil Kepala Madrasah Bagian Kurikulum (sebagai penanggung jawab sarana prasarana). Perencanaan sarana dan prasarana dimulai dari analisis kebutuhan yang dilakukan oleh Staff Wakil Kepala Kurikulum bagian Sarpras kemudian diajukan kepada Waka Kurikulum. Pengadaan sarana dan prasarana dilakukan berdasarkan pada analisis kebutuhan yang diajukan oleh Wakil Kepala Kurikulum, kemudian direkap kebutuhan mana yang lebih diprioritaskan. Penggunaan sarana dan prasarana dilakukan sesuai dengan standart operational procedure (SOP). Berbeda barang yang digunakan maka berbeda pula prosedur yang dilakukan. Penghapusan dilakukan karena barang tersebut mengalami rusak berat dan tidak dapat diperbaiki lagi dan seandainya diperbaiki, perbaikan tersebut memerlukan biaya yang cukup besar, sehingga pengadaan barang baru menjadi keputusan pihak sekolah dari pada memperbaikinya.
Diagnosis, clinic and treatment of tuberculosis
Authors: Editorial Article 
Published: August 2024

В соответствии с планом научно-образовательных и конгрессно-выставочных мероприятий на 2022 год под патронатом Департамента здравоохранения города Москвы ГБУЗ «МНПЦ борьбы с туберкулезом Департамента здравоохранения города Москвы» совместно с Межрегиональной общественной организацией «Московское общество фтизиатров» провели 1–2 сентября 2022 года Х Ежегодную конференцию московских фтизиатров «Латентная туберкулезная инфекция в мегаполисе: эпидемиология, методы диагностики и ведения пациентов», целью которой было дальнейшее совершенствование работы противотуберкулезных учреждений города Москвы.В этом номере журнала мы завершаем публикацию поступивших в адрес Оргкомитета конференции тезисов, охватывающих все многообразие проблемы защиты населения от туберкулеза.При подготовке публикации проведена только техническая и редакторская правка; термины и дефиниции сохранены в авторской редакции.
The 2019 Tax Competitiveness Report: Canada’s Investment and Growth Challenge
Authors: Mintz Jack , Bazel Philip 
Published: August 2024

After a decade of corporate tax reform, the 2012 Tax Competitiveness Report (Chen and Mintz 2012) came to the conclusion that Canada’s record was a good news story: more investment and growth with corporate tax revenues as a share of GDP little changed despite the sharp reduction in the general corporate income tax rate. Since that time, much has changed.
The oil production response to Alberta's government-mandated quota
Authors: Hallak Amir , Jensen Adam , Lybbert Gilbert , Muehlenbachs Lucija 
Published: August 2024

Two years ago, the Alberta government put in place a temporary oil-production quota. However, the quota’s impact could well be felt in the province’s oil production for years to come. The quota applied only to firms producing more than 10,000 barrels of oil per day and was instituted as a response to pipeline constraints that caused Alberta oil prices to be much lower than prices elsewhere. Production from both oilsands mines and oil wells dropped as soon as the government announced the quotas. The media warned that the quotas would force production to transfer to Saskatchewan, but the research for this paper found that this never occurred.
The quota policy was announced in December 2018 and a week later, the price of Alberta oil had jumped from $29.09/bbl to $50.08 bbl, a 72 per cent rise. When the quota policy actually took effect the first of January 2019, the price increased again, but by much less. The anticipation of the quota alone was enough to create the desired price increase.
The quota, which set limits for the total combined crude oil and bitumen permitted to be produced, was assigned to individual operators and designed to provide an 8.5 per cent reduction in oil production. The total quota was fixed at 3.56 million barrels a day in January 2019, but individual quotas could be traded across eligible operators, minimizing the overall costs of achieving the total goal. However, total production continued falling even when the quota was eventually relaxed; the market and a low world price created a scenario in which production fell below the amount permitted by the quota. All the oil companies reduced their production regardless of whether they fell within the quota’s guidelines or not; however, the firms that were subject to the quota reduced their production more than the others. The quota was lifted in December 2020 when export capacity again became sufficient.
While curtailing production had the desired result of raising Alberta oil prices and resolving the differential between local prices and the world benchmark, its ripple effects may well be felt in the longer term. This paper finds that fewer wells are being drilled and more wells are suspending production. Tradition dictates that when a well becomes inactive, it is rarely returned to a productive state. Those firms that resorted to low levels of drilling in order to meet the quota have created a situation that could affect Alberta oil production in the years ahead.