bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytic Characteristics of Three Bayer Contour Blood Glucose Monitoring Systems in Neonates
Authors: Dietzen Dennis J. , Nenninger Denise A. , Simmons David A. , Pardo Scott , Pandya Mauli , Fullam Jeanellen 
Published: November 2014

Background: Hypoglycemia in infants is common, is difficult to recognize, and may lead to permanent neurologic impairment. Low glucose concentrations and high hematocrits in newborns pose significant analytic challenges for whole blood glucose meters. Objective/Methods: Three Bayer glucose monitoring systems were evaluated using 211 blood samples from 162 neonates (age range 5 hours to 29 days, median age 3 days). Hematocrit and whole blood glucose were determined in heparinized whole blood, and plasma glucose was determined using the Roche Cobas® 6000. Accuracy was evaluated against plasma concentrations using ISO 15197:2013 and CLSI POCT 12-A3 criteria. Results: Glucose imprecision on the Cobas system was 1.8-2.6% (CV) from 26-610 mg/dL. Imprecision across all meter systems was 2.8% (CV) at 130 mg/dL. Glucose concentrations, hematocrit, and total bilirubin ranged from 20-150 mg/dL, 18 -75%, and 0.5-19.6 mg/dL, respectively. Linear regression analysis of whole blood versus plasma for the 3 combined systems yielded an average slope of 1.06 and correlation coefficient greater than 0.980. Bias between the Contour and Cobas was not significantly correlated with hematocrit. Greater than 99% of meter results were within 15 mg/dL and 20% of plasma results at glucose concentrations ≤ 75 and > 75 mg/dL, respectively. Of meter results, 97% were within 12.5 mg/dL of plasma results at concentrations ≤ 100 mg/dL, while 96% of meter results were within 12.5% of plasma at concentrations > 100 mg/dL. Conclusions: The Bayer CONTOUR Blood Glucose Monitoring Systems exceed ISO 15197:2013 and CLSI criteria in neonatal blood samples.
Long‐acting somatostatin analogues provide significant beneficial effect in patients with refractory small bowel angiodysplasia: Results from a proof of concept open label mono‐centre trial
Authors: Holleran Grainne , Hall Barry , Breslin Niall , McNamara Deirdre 
Published: November 2014

IntroductionSmall bowel angiodysplasias account for over 50% of causes of small bowel bleeding and carry a worse prognosis than lesions located elsewhere in the gastrointestinal tract. Re‐bleeding rates are high even after first‐line endoscopic therapy and are associated with high levels of morbidity for affected patients. Small trials of long‐acting somatostatin analogues have shown promising results but have not yet been assessed in patients with refractory small bowel disease.AimThe purpose of this study was to assess the effect of long‐acting somatostatin analogues in reducing re‐bleeding rates and transfusion requirements, and improving haemoglobin levels in patients with refractory small bowel angiodysplasia.MethodsPatients with refractory small bowel angiodysplasia were treated with 20 mg of long‐acting octreotide for a minimum of three months. Response was assessed according to: rates of re‐bleeding, haemoglobin levels, transfusion requirements, and side effects.ResultsA total of 24 patients were initially treated and 20 received at least three doses. Rates of complete, partial and non‐response were 70%, 20% and 10% respectively. Average haemoglobin rates increased from 9.19 g/dl to 11.35 g/dl (p  = 0.0027, 95% confidence interval (CI) −3.5 to −1.1) in the group overall and 70% remained transfusion‐free after a mean treatment duration of 8.8 months. The rate of adverse events was higher than previously reported at 30%.ConclusionLong‐acting somatostatin analogues offer a therapeutic advantage in a significant proportion of patients with small bowel angiodysplasia. With careful patient selection and close observation, a long‐acting somatostatin analogue should be considered in all patients with persistent anaemia attributable to refractory disease in conjunction with other standard treatments.
How I treat poisoning with vitamin K antagonists
Authors: Schulman Sol , Furie Bruce 
Published: November 2014

AbstractSevere deficiency of vitamin K–dependent proteins in patients not maintained on vitamin K antagonists is most commonly associated with poisoning by or surreptitious ingestion of warfarin, warfarin-like anticoagulants, or potent rodenticides (“superwarfarins”), such as brodifacoum. Serious bleeding manifestations are common. Superwarfarins are 2 orders of magnitude more potent than warfarin and have a half-life measured in weeks. These rodenticides are readily available household environmental hazards and are sometimes consumed accidentally or as manifestations of psychiatric disease. Immediate diagnosis and proper therapy is critically important to minimize morbidity and mortality because this condition, affecting thousands of patients annually, is reversible. Treatment with large doses of oral vitamin K1, often over months to years, to maintain a near-normal prothrombin time can reverse the coagulopathy associated with superwarfarins. Although these patients initially present to various medical specialties, the hematologist is often consulted to offer the definitive diagnosis and proper therapy.
Diagnosis and allergen immunotherapy treatment of polysensitised patients with respiratory allergy in Spain: an Allergists’ Consensus
Authors: Vidal Carmen , Enrique Ernesto , Gonzalo Angeles , Moreno Carmen , Tabar Ana I ,   Expert Clinical Participants
Published: November 2014

AbstractBackgroundPolysensitisation is common in patients with respiratory allergy in Spain. Selection of the best allergen immunotherapy (AIT) is difficult in polysensitised patients. The present study was designed to help allergists better identify relevant allergens in these patients and to improve the selection of AIT in Spain.MethodsSixty‐two Spanish allergists answered a survey containing 88 items divided into four groups: 1) general approach to polysensitised subjects; 2) sensitisation profile involving mite, animal dander and moulds; 3) grass and olive pollen co‐sensitisation, and 4) other pollen polysensitisation profile (weed and tree pollen). The Delphi method was used.ResultsA consensus was achieved for 83% of items (92%, 81%, 83% and 73% of the four groups analysed, respectively). Only polysensitised patients with clinical relevance should be considered polyallergic. A detailed medical history (clinical symptoms and medication) together with a profound knowledge of allergens present in the patient's environment are essential for diagnosis. Skin prick tests (SPTs) are not adequate to decide the clinical relevance of each allergen. Serum specific IgE against allergen sources adds value to SPT but molecular diagnosis, when possible, is strongly recommended, especially in pollen‐allergic patients. Specific allergen challenge tests are difficult to perform and not recommended for daily practice. Regarding AIT composition, up to three allergens can be used in the same vaccine, but only related allergens may be mixed. In some cases more than one vaccine may be needed.ConclusionSome criteria have been established to improve diagnosis and AIT prescription in polysensitised patients.
A comprehensive discussion on colour conversion element design of phosphor converted LEDs
Authors: Schweitzer Susanne , Sommer Christian , Hartmann Paul , Fulmek Paul , Nicolics Johann , Pachler Peter , Hoschopf Hans , Schrank Franz , Langer Gregor , Wenzl Franz P 
Published: November 2014

Abstract
For a systematic approach to improve the white light quality of phosphor converted light-emitting diodes (LEDs) for general lighting applications it is imperative to get the individual sources of error for correlated colour temperature (CCT) reproducibility and maintenance under control. In this regard, it is of essential importance to understand how geometrical, optical and thermal properties of the colour conversion elements (CCEs), which typically consist of phosphor particles embedded in a transparent matrix material, affect the constancy of a desired CCT value. In this contribution we use an LED assembly consisting of an LED die mounted on a printed circuit board by chip-on-board technology and a CCE with a globe-top configuration on the top of it as a model system and discuss the impact of the CCE size, the substrate reflectivity as well as the thermal load of the CCEs on CCT maintenance and the respective radiant fluxes. It turns out that optimized solutions for CCT maintenance and high radiant fluxes in regard of one of the relevant influence factors do not need to be optimized solutions in regard of another one.
Cash for Coolers: Evaluating a Large-Scale Appliance Replacement Program in Mexico
Authors: Davis Lucas W. , Fuchs Alan , Gertler Paul 
Published: November 2014

This paper evaluates a large-scale appliance replacement program in Mexico that from 2009 to 2012 helped 1.9 million households replace their old refrigerators and air conditioners with energy-efficient models. Using household-level billing records from the universe of Mexican residential customers, we find that refrigerator replacement reduces electricity consumption by 8 percent, about one-quarter of what was predicted by ex ante analyses. Moreover, we find that air conditioning replacement actually increases electricity consumption. Overall, we find that the program is an expensive way to reduce externalities from energy use, reducing carbon dioxide emissions at a program cost of over $500 per ton. (JEL L68, L94, O12, O13, Q41, Q54)
Mobile translators for non-English-speaking women accessing maternity services
Authors: Haith-Cooper Melanie 
Published: November 2014

It is becoming increasingly common for midwives to care for women who do not speak English, and UK interpreting services are often inadequate and underused. Persistent language barriers have been found to contribute to maternal and perinatal mortality thus it is essential that these barriers are overcome to provide safe maternity care. This article reports on a two-stage study undertaken to address this. The study aimed to: • Identify difficulties midwives experience when communicating with non-English-speaking women. Through undertaking a group interview with 11 senior students, four themes emerged: accessing interpreters, working with interpreters, cultural barriers and strategies to address persistent language barriers • Explore the feasibility of using mobile devices with a translation application to communicate in clinical practice. Google Translate was tested in a simulated clinical environment with multi-lingual service users. Google Translate was not adequately developed to be safely used in maternity services. However, a maternity-specific mobile application could be built to help midwives and women communicate in the presence of a persistent language barrier.
Cemented stems
Authors: Mullaji A. , Shetty G. M. 
Published: November 2014

Stems may improve fixation and stability of components during revision total knee replacement. However, the choice between cemented and cementless stems is not a clear one. Cemented stems offer several advantages in terms of versatility, mechanical stability, surgical technique and clinical outcome over their cementless counterpart. Cite this article: Bone Joint J 2014;96-B(11 Suppl A):115–7.
Patient dissatisfaction following total knee replacement
Authors: Nam D. , Nunley R. M. , Barrack R. L. 
Published: November 2014

A national, multi-centre study was designed in which a questionnaire quantifying the degree of patient satisfaction and residual symptoms in patients following total knee replacement (TKR) was administered by an independent, blinded third party survey centre. A total of 90% of patients reported satisfaction with the overall functioning of their knee, but 66% felt their knee to be ‘normal’, with the reported incidence of residual symptoms and functional problems ranging from 33% to 54%. Female patients and patients from low-income households had increased odds of reporting dissatisfaction. Neither the use of contemporary implant designs (gender-specific, high-flex, rotating platform) or custom cutting guides (CCG) with a neutral mechanical axis target improved patient-perceived outcomes. However, use of a CCG to perform a so-called kinematically aligned TKR showed a trend towards more patients reporting their knee to feel ‘normal’ when compared with a so called mechanically aligned TKR This data shows a degree of dissatisfaction and residual symptoms following TKR, and that several recent modifications in implant design and surgical technique have not improved the current situation. Cite this article: Bone Joint J 2014;96-B(11 Suppl A):96–100.
Periprosthetic fractures
Authors: Yasen A. T. , Haddad F. S. 
Published: November 2014

We are currently facing an epidemic of periprosthetic fractures around the hip. They may occur either during surgery or post-operatively. Although the acetabulum may be involved, the femur is most commonly affected. We are being presented with new, difficult fracture patterns around cemented and cementless implants, and we face the challenge of an elderly population who may have grossly deficient bone and may struggle to rehabilitate after such injuries. The correct surgical management of these fractures is challenging. This article will review the current choices of implants and techniques available to deal with periprosthetic fractures of the femur.Cite this article: Bone Joint J 2014;96-B(11 Suppl A):48–55.
The unstable knee
Authors: Abdel M. P. , Haas S. B. 
Published: November 2014

Instability after total knee replacement (TKR) accounts for 10% to 22% of revision procedures. All patients who present for evaluation of instability require a thorough history to be taken and physical examination, as well as appropriate imaging. Deep periprosthetic infection must be ruled out by laboratory testing and an aspiration of the knee must be carried out. The three main categories of instability include flexion instability, extension instability (symmetric and asymmetric), and genu recurvatum. Most recently, the aetiologies contributing to, and surgical manoeuvres required to correct, flexion instability have been elucidated. While implant design and patient-related factors may certainly contribute to the aetiology, surgical technique is also a significant factor in all forms of post-operative instability.Cite this article: Bone Joint J 2014;96-B(11 Suppl A):112–4.
Cementless total knee replacement fixation
Authors: Kwong L. M. , Nielsen E. S. N. , Ruiz D. R. , Hsu A. H. , Dines M. D. , Mellano C. M. 
Published: November 2014

A retrospective review was performed of patients undergoing primary cementless total knee replacement (TKR) using porous tantalum performed by a group of surgical trainees. Clinical and radiological follow-up involved 79 females and 26 males encompassing 115 knees. The mean age was 66.9 years (36 to 85). Mean follow-up was 7 years (2 to 11). Tibial and patellar components were porous tantalum monoblock implants, and femoral components were posterior stabilised (PS) in design with cobalt–chromium fibre mesh. Radiological assessments were made for implant positioning, alignment, radiolucencies, lysis, and loosening. There was 95.7% survival of implants. There was no radiological evidence of loosening and no osteolysis found. No revisions were performed for aseptic loosening. Average tibial component alignment was 1.4° of varus (4°of valgus to 9° varus), and 6.2° (3° anterior to 15° posterior) of posterior slope. Mean femoral component alignment was 6.6° (1° to 11°) of valgus. Mean tibiofemoral alignment was 5.6° of valgus (7° varus to 16° valgus). Patellar tilt was a mean of 2.4° lateral (5° medial to 28° lateral). Patient satisfaction with improvement in pain was 91%. Cementless TKR incorporating porous tantalum yielded good clinical and radiological outcomes at a mean of follow-up of seven-years.Cite this article: Bone Joint J 2014;96-B(11 Suppl A):87–92.
Noninvasive Prenatal Testing for Wilson Disease by Use of Circulating Single-Molecule Amplification and Resequencing Technology (cSMART)
Authors: Lv Weigang , Wei Xianda , Guo Ruolan , Liu Qin , Zheng Yu , Chang Jiazhen , Bai Ting , Li Haoxian , Zhang Jianguang , Song Zhuo , Cram David S , Liang Desheng , Wu Lingqian 
Published: November 2014

Abstract

BACKGROUND
Noninvasive prenatal testing (NIPT) for monogenic diseases by use of PCR-based strategies requires precise quantification of mutant fetal alleles circulating in the maternal plasma. The study describes the development and validation of a novel assay termed circulating single-molecule amplification and resequencing technology (cSMART) for counting single allelic molecules in plasma. Here we demonstrate the suitability of cSMART for NIPT, with Wilson Disease (WD) as proof of concept.

METHODS
We used Sanger and whole-exome sequencing to identify familial ATP7B (ATPase, Cu++ transporting, β polypeptide) gene mutations. For cSMART, single molecules were tagged with unique barcodes and circularized, and alleles were targeted and replicated by inverse PCR. The unique single allelic molecules were identified by sequencing and counted, and the percentage of mutant alleles in the original maternal plasma sample was used to determine fetal genotypes.

RESULTS
Four families with WD pedigrees consented to the study. Using Sanger and whole-exome sequencing, we mapped the pathogenic ATP7B mutations in each pedigree and confirmed the proband's original diagnosis of WD. After validation of cSMART with defined plasma models mimicking fetal inheritance of paternal, maternal, or both parental mutant alleles, we retrospectively showed in second pregnancies that the fetal genotypes assigned by invasive testing and NIPT were concordant.

CONCLUSIONS
We developed a reliable and accurate NIPT assay that correctly diagnosed the fetal genotypes in 4 pregnancies at risk for WD. This novel technology has potential as a universal strategy for NIPT of other monogenic disorders, since it requires only knowledge of the parental pathogenic mutations.
The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva
Authors: Bahn Jae Hoon , Zhang Qing , Li Feng , Chan Tak-Ming , Lin Xianzhi , Kim Yong , Wong David T W , Xiao Xinshu 
Published: November 2014

Abstract

BACKGROUND
Extracellular RNAs (exRNAs) in human body fluids are emerging as effective biomarkers for detection of diseases. Saliva, as the most accessible and noninvasive body fluid, has been shown to harbor exRNA biomarkers for several human diseases. However, the entire spectrum of exRNA from saliva has not been fully characterized.

METHODS
Using high-throughput RNA sequencing (RNA-Seq), we conducted an in-depth bioinformatic analysis of noncoding RNAs (ncRNAs) in human cell-free saliva (CFS) from healthy individuals, with a focus on microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and circular RNAs (circRNAs).

RESULTS
Our data demonstrated robust reproducibility of miRNA and piRNA profiles across individuals. Furthermore, individual variability of these salivary RNA species was highly similar to those in other body fluids or cellular samples, despite the direct exposure of saliva to environmental impacts. By comparative analysis of &gt;90 RNA-Seq data sets of different origins, we observed that piRNAs were surprisingly abundant in CFS compared with other body fluid or intracellular samples, with expression levels in CFS comparable to those found in embryonic stem cells and skin cells. Conversely, miRNA expression profiles in CFS were highly similar to those in serum and cerebrospinal fluid. Using a customized bioinformatics method, we identified &gt;400 circRNAs in CFS. These data represent the first global characterization and experimental validation of circRNAs in any type of extracellular body fluid.

CONCLUSIONS
Our study provides a comprehensive landscape of ncRNA species in human saliva that will facilitate further biomarker discoveries and lay a foundation for future studies related to ncRNAs in human saliva.
„Strategieentwicklung und Neuorganisation ZB MED“ oder „Was Shakespeare mit dem Leibniz-Informationszentrum Lebenswissenschaften verbindet“
Authors: Roesner Elke 
Published: November 2014

Zusammenfassung:
Spätestens seit 2012 ist ein massiver Veränderungsdruck in der Deutschen Zentralbibliothek für Medizin (ZB MED) vorhanden. Aus einer eher klassischen Spezialbibliothek soll eine stärker an der Forschung ausgerichtete, rechtlich selbstständige Einrichtung werden. Ziele sind es, das Dienstleistungsangebot an neuen Informationsbedarfen auszurichten und sich durch Hochschulkooperationen und Forschung und Entwicklung auszuzeichnen, um ein konkurrenzfähiger Fachinformationsdienstleister zu bleiben. Das daraus abgeleitete Projekt „Strategie- und Neuorganisationsprozess ZB MED“ wird beschrieben, Erfahrungen werden diskutiert und allgemein nutzbare Lessons learned für Veränderungsprozesse in Bibliotheken abgeleitet.
Lautsymbolik – ein vernachlässigter Forschungsgegenstand der Sprachwissenschaft
Authors: Elsen Hilke 
Published: November 2014

AbstractAs texts about sound symbolism are currently missing, this article wants to inspire new interest in this topic. To begin with, earlier studies are surveyed which dealt directly with sound symbolism in various empiric ways. Next, fields of research are depicted which presently touch upon sound symbolism, such as language evolution, synesthesia, ideophones, names in literature and brand names. It will be argued that research in sound symbolism proper could help to support and even put into perspective some quite hasty results in neighbouring disciplines.
Epithelial–stromal interaction via Notch signaling is essential for the full maturation of gut‐associated lymphoid tissues
Authors: Obata Yuuki , Kimura Shunsuke , Nakato Gaku , Iizuka Keito , Miyagawa Yurika , Nakamura Yutaka , Furusawa Yukihiro , Sugiyama Machiko , Suzuki Keiichiro , Ebisawa Masashi , Fujimura Yumiko , Yoshida Hisahiro , Iwanaga Toshihiko , Hase Koji , Ohno Hiroshi 
Published: November 2014

AbstractIntrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut‐associated lymphoid tissue (GALT), stromal cells located beneath the follicle‐associated epithelium (FAE) abundantly express the Notch ligand delta‐like 1 (Dll1). Here, we show that mice lacking Rbpj—a gene encoding a transcription factor implicated in Notch signaling—in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down‐regulation of CCL20 in FAE. These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE.
Suppressing nonsense—a surprising function for 5‐azacytidine
Authors: Shao Ada , Wilkinson Miles F 
Published: November 2014

In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but that in certain cases can be detrimental because it eliminates “useful” garbage. The chemical inhibitor identified by Bhuvanagiri et al perturbs Nonsense‐Mediated RNA Decay (NMD), a RNA surveillance pathway that targets mRNAs harboring premature termination codons (PTCs) for degradation (Kervestin & Jacobson, ).