bluuebunny/crossref_metadata_2025_split huggingface dataset:
HERPES GESTATIONIS ASSOCIATED WITH ECTOPIC PREGNANCY
Authors: Miyagawa Sachiko , Yoshioka Junko , Morita Michiko , Sakamoto Kuniki 
Published: April 2015

AbstractA patient with herpes gestationis associated with ectopic pregnancy is reported. She had circulating antibodies against basement membrane zone (BMZ) antigens of skin, in vivo deposition of IgG and complement components in a linear pattern along the BMZ of lesional skin, and positive herpes gestationis factor activity. Herpes gestationis associated with ectopic pregnancy has not been previously reported.
CLINICAL FEATURES AND AN ULTRASTRUCTURAL STUDY OF EHLERS‐DANLOS SYNDROME TYPE II
Authors: Igarashi Minoru , Katsumata Makiko , Masu Shin‐Ichi , Seiji Makoto , Watanabe Nikichi 
Published: April 2015

AbstractHistopathological and ultrastructural studies were carried out on a case of a 4‐year‐old boy with type II Ehlers‐Danlos Syndrome. The patient showed velvety skin, hyperelasticity of the skin, and mild hypermobility of the joints. Histopathologically, numerous very fine collagen fibers were observed in the dermis, and no recognisable group substance was found. Ultrastructurally, abnormal collagen fibrils with irregular profiles were interspersed in the reticular dermis. However, their periodic band pattern was that of normal skin collagen. It is supposed that these abnormalities of fibrils are due to abnormalities of collagen fibrillogenesis.
ROLLED HAIRS AND HYPERTRICHOSIS
Authors: Maekawa Yoshihiro , Kito Masato , Hiramatsu Rhyoji 
Published: April 2015

ABSTRACTA 15 year old Japanese girl, who had suffered from juvenile hypothyroidism noted hypertrichosis and hyperkeratosis on her back and extensor aspects of upper arms. Rolled hairs were seen under a thin transluscent horny layer. These rolled hairs were produced by a follicular plug of keratin which inhibited growing miniature hairs.
QUANTITATIVE AND QUALITATIVE STUDIES OF MEISSNER'S CORPUSCLES IN HUMAN SKIN, WITH SPECIAL REFERENCE TO ALTERATIONS CAUSED BY AGING
Authors: Matsuoka Susumu , Suzuki Hiroyuki , Morioka Sadao , Ogawa Yoshiaki , Kojima Tokuzo 
Published: April 2015

ABSTRACTWe observed age‐related changes in Meissner's corpuscles, one type of cutaneous sensory receptor, in subjects ranging from their 20s to their 70s.Nerve fibers in Meissner's corpuscles were observed by the silver impregnation technique. They changed morphologically with aging. Meissner's corpuscles are supplied by one to four myelinated nerve fibers, most frequently one or two, from the lower portion, and, most densely, from the basal portion. By morphometric analyses, the size of Meissner's corpuscles was found to increase with aging, but to decrease during the 70s. Furthermore, this size change depends upon the size of the lamellar cells in the direction of the long axis, and, among subjects in their 60s, in the direction of the short axis as well.The shape of Meissner's corpuscles becomes more complicated with age due to twisted alterations. This change occurs markedly during the 60s.
IMPROVED METHODS FOR THE DEMONSTRATION OF TREPONEMA PALLIDUM IN THE TISSUES
Authors: Nakamura Shinichi , Ito Fumiyuki , Nakamura Saeko , Onda Shutaro 
Published: April 2015

ABSTRACTSilver stains are well known as reliable for demonstrating Treponema pallida (T.P.) in the tissues, but sometimes it is difficult to distinguish T.P. from the tissue elements in tissue sections. We now present a new method for demonstrating T.P. in the tissues using FTA‐ABS complement staining and scanning electron microscopy in the same materials embedded in paraffin.
ANTIGEN IN CONTACT SENSITIVITY
Authors: Oka Daisuke , Nakagawa Shojiro , Ueki Hiroaki , Kumon Hiromi , Ohmori Hiroyuki 
Published: April 2015

ABSTRACTThe distribution of DNP groups on epidermal single cells and epidermal sheets prepared from the skin of guinea pigs three hours after painting with 5% DNCB‐ethanol solution was examined by scanning immunoelectron microscopy using bacteriophage T4 as a visual marker. The study showed that DNP groups were distributed diffusely on the surface of epidermal cells, in particular keratinocytes, and suggests that DNCB may bind to the surface components of epidermal cells when painted on the skin.
COLLAGEN POLYMORPHISM: TYPE V COLLAGEN IN NEUROFIBROMA
Authors: Shinkai Hiroshi 
Published: April 2015

ABSTRACTThree types of collagen were found in neurofibroma tumor tissue from a patient with neurofibromatosis (Von Recklinghausen's disease). Two of them were determined to be type I and type III collagen by CM‐cellulose chromatography and SDS‐polyacrylamide gel electrophoresis. The third matched a membrane type collagen from amnionic and chorionic membrane of human placenta in its elution profile during CM‐cellulose chromatography and its electrophoretic patterns on SDS‐polyacrylamide gel. This collagen was precipitated with 3.6‐4.0 M NaCl at neutral pH after limited pepsin digestion. It was composed of two components with molecular weights of approximately 110K and 125K daltons. These collagenous constituents had a high content of hydroxylysine linked disaccharide units (glucosylgalactose) and were resistant to reduction. They were digested by bacterial collagenase (EC 3.4.24.3) but resisted tadpole collagenase (EC 3.4.24.7).
TRANSEPITHELIAL ELIMINATION OF NEVUS CELL NESTS
Authors: Yuki Naokata , Shitara Atsuyuki , Ito Masaaki , Sato Yoshio 
Published: April 2015

ABSTRACTThree hundred and three biopsy specimens of nevocellular nevus were histologically examined from the point of view of the elimination phenomenon. Transepidermal elimination of nevus cell nests was observed in 6 cases. The incidence ratio of the elimination phenomenon was 5.4% in 111 nevi with junctional activity. There was a correlation between histological type of nevocellular nevus and patient age. With aging, the number of cases of both compound and junctional types tended to decrease, whereas the proportion of the intradermal type tended to increase. The elimination phenomenon may play an important role in the histological transition of nevocellular nevus with aging.
POSSIBILITY OF PASSIVE TRANSFER OF COLD URTICARIA TO GUINEA PIGS
Authors: Katayama Ichiro , Doi Toshiaki , Nishioka Kiyoshi 
Published: April 2015

ABSTRACTSerum from one out of six patients with idiopathic acquired cold urticaria produced a short lived edematous reaction in the pinna of guinea pigs 24 hours after intradermal injection of the patient's serum and subsequent cold challenge. No relationship was observed between the transfer activity and IgE titer or atopic status.
THE SO‐CALLED MOBILE ENCAPSULATED LIPOMA
Authors: Kikuchi Ichiro , Okazaki Michiharu , Narahara Shin‐Ichiro 
Published: April 2015

ABSTRACTThe so‐called mobile encapsulated lipoma of Sahl was seen in a 10‐year‐old boy. It was characterized by a distinct eosinophilic capsule containing degenerating fatty tissue which was separating or had separated from the neighboring tissue. It appeared to be a type of adiponecrosis, not a lipoma.
LIPID PEROXIDATION AND RADICAL FORMATION IN METHYL LINOLEATE FOLLOWING ULTRAVIOLET LIGHT EXPOSURE
Authors: Sugiyama Masayasu , Kajiyama Kiminori , Hidaka Toshihiro , Kumano Shuji , Ogura Ryohei 
Published: April 2015

ABSTRACTTo gain information useful in understanding radical reactions of sunlight‐induced lipid peroxidation in the skin, methyl linoleate (ML) was used as a material for a study of electron spin resonance (ESR). The ESR spectrum of ML exposed to UV light was examined under aerobic and anaerobic conditions at low temperature. No ESR signal was detected from the unexposed ML, even at —150°C. However, exposure to UV resulted in the appearance of an ESR signal at —150°C. With the elevation of temperature from —150°C, the ESR signal became asymmetric in shape and the g value increased under aerobic conditions, but these alterations did not occur under anaerobic conditions. Lipid peroxidation through a radical reaction initiated by UV exposure was discussed.
A CASE OF SCLERODERMA ASSOCIATED WITH PITUITARY TUMOR
Authors: Kohchiyama Akira , Hatamochi Atsushi , Ueki Hiroaki 
Published: April 2015

ABSTRACTA 46‐year‐old man had sclerosis of the skin of the hands, face and upper back, sclerodactyly, contracture of finger joints, well‐defined erythema of palms, pigmentation over the whole body with depigmentation, multiple morphea, telangiectasia, muscular atrophy, and loss of axillary and pubic hair as well as a visual field defect. A skull X‐ray and brain CT scan revealed a pituitary tumor. Hormonal examination revealed a marked decrease in the secretory reserves of HGH, LH and FSH. The relationship between the hormonal effect of the pituitary tumor and the occurrence of scleroderma was discussed.
PATHOGENETIC STUDIES IN BULLOUS PEMPHIGOID—REVIEW OF THE LITERATURE AND OUR OWN RESULTS
Authors: Haustein Uwe‐Frithjof , Lohrisch Ingo , Herrmann Konrad 
Published: April 2015

ABSTRACTBullous pemphigoid (bP) is a blister‐forming disease, probably of autoimmune nature. Its genetic background has not been established yet. Associations with other autoimmune diseases and, to some extend, with malignant tumors are noteworthy. The blisters are located subepidermally in the lamina lucida between the cytoplasmic membrane of the basal cells and the lamina densa of the basement membrane. The bP antigen, which is produced by basal cells, serves as an attachment factor and can be liberated into the blister fluid, probably by serine proteases from leucocytes. The formation of antigen‐antibody complexes is favoured afterwards. Freely circulating bP antibodies, mostly of the IgG class, are fixed in the skin tissue in vivo and in vitro and bind complement. Components of the classical complement pathway as well as of the amplification loop are activated locally in the skin tissue and fixed. The content of immune complexes is increased in the serum and in the blister fluid. They partially consist of specific bP antigen‐antibody complexes. The determination of the entire bP antibody titer (after immune complex splitting) correlates well with the clinical course of the disease.Chemotactic factors for neutrophils and eosinophils are released into the blister fluid after complement activation, so that leucocyte attraction is mediated. Deviations of humoral and cellular immune reactivity have not been studied sufficiently. There might be an immune modulating effect of immune complexes and other serum factors on T‐lymphocytes due to steric hindrance of surface receptors. In vivo and in vitro models in rabbit cornea, skin explants, and frozen sectioned skin tissue suggest that the interaction of circulating bP antibodies with the bP antigen followed by complement activation and attraction of neutrophils might be the primary immunopathological mechanism, producing an immune complex mediated inflammation.
Adolescence Mycosis Fungoides: An Unusual Presentation with Hypopigmentation
Authors: El‐Hoshy Khaled , Hashimoto Ken 
Published: April 2015

AbstractMycosis fungoides (M.F.) is a rare cutaneous malignancy of childhood and adolescence. The disease commonly presents with the classic sequence of erythematous patches and plaques. Hypopigmentation as the presenting symptom is distinctly rare. This is the 9th case report of M.F. presenting with hypopigmentation in a patient under 20 years of age. The disease was only partially controlled with PUVA therapy, necessitating nitrogen mustard treatment.
Se redefinen las fronteras de las relaciones laborales. Aportaciones desde Sudáfrica
Authors: WEBSTER Edward 
Published: April 2015

ResumenLas turbulentas relaciones laborales sudafricanas posapartheid y otras protestas sociales más generales ponen de manifiesto los retos que afrontan los sistemas de relaciones laborales en el mundo, sugiriendo cómo podrían reconfigurarse en el futuro. Los sindicatos tradicionales siguen sin las respuestas a la marginación, la desigualdad y la pobreza que les capacitarían para integrar a los trabajadores actualmente excluidos del movimiento sindical. Mientras tanto, la globalización posibilita nuevas formas de organización e innovación institucional. Según el autor, el desenlace dependerá de cómo respondan los actores principales del ámbito laboral a los trabajadores marginados del mundo.
Improving awareness, knowledge and heart‐related lifestyle of coronary heart disease among working population through a mHealth programme: study protocol
Authors: Wang Wenru , Zhang Hui , Lopez Violeta , Wu Vivien Xi , Poo Danny Chiang Choon , Kowitlawakul Yanika 
Published: April 2015

AbstractAimTo develop a mHealth programme, entitled ‘Care4Heart’ for the working population in Singapore and thereafter examine its feasibility and effectiveness in increasing the awareness and knowledge of coronary heart disease and improving their heart‐related lifestyle.BackgroundTeaching and encouraging the working population to adopt a healthier lifestyle could result in preventing and/or decreasing the incidence of coronary heart disease among this population. The use of mobile application (app) is the next logical wave of healthcare support tools to prevent and manage chronic diseases like coronary heart disease.DesignA quasi‐experimental longitudinal study design.MethodsThe study will be conducted in a tertiary university in Singapore. A non‐probability, quota sampling of 200 participants will be recruited including 100 academic and research staff, 50 administrative staff and 50 support staff and business owners. Once consent is obtained, the newly developed mobile app will be installed onto the participants’ smartphones and a well‐trained research assistant will brief the participant on the use of the app. The main outcomes will be measured using the survey questionnaires: Awareness of coronary heart disease, Heart Disease Fact Questionnaire‐2, Behavioural Risk Factor Surveillance System and Perceived Stress Scale. Data will be collected at baseline and at the 4th week and 6th month thereafter.DiscussionIf this project is successful, Care4Heart – a mHealth and novel prevention educational programme for the working population in Singapore – can be used to promote knowledge and positive heart‐related lifestyle changes to prevent coronary heart disease.
Family‐Style Dining on a Child and Adolescent Psychiatry Unit: A Quality Improvement Project to Reduce Weight Changes in Patients
Authors: Praglowski Nancy 
Published: April 2015

BackgroundImproving nutritional standards for children has become a national health initiative. However, children who are hospitalized are often at additional risk for poor nutrition and diet. Following a change to family‐style dining, nursing staff noted significant patient weight changes. We undertook a quality improvement project to address this issue and promote healthy weight maintenance.MethodsNursing staff requested changes to the types of foods served and placed limits on how much patients were permitted to eat. We also developed a nutrition group to educate the patients on healthy food choices.ResultsWe were able to reduce weight changes in patients on our unit from a mean change of 2.5 kg (5.5 lb) to a mean change of 0.01 kg (0.027 lb).ConclusionsPatient education, healthy food offerings, and limiting the amount of food eaten at meals had positive outcomes on patient weights during a child and adolescent psychiatry hospitalization.
Physicochemical Properties and Determination of Key Instrumental Quality Measurement Parameters of Frozen‐Cooked Rice by Correlating Consumer Acceptance
Authors: Kwak Han Sub , Kim Misook , Jeong Yoonhwa 
Published: April 2015

AbstractPhysicochemical properties and consumer evaluation of frozen‐cooked rice made in five rice varieties were investigated. Rice quality evaluation, physicochemical analyses, rapid viscometer analysis, texture measurements and mechanical sensory measurements were conducted. Consumer acceptance test was conducted with 51 consumers. Consumer acceptance ratings were highly correlated with hardness (r = −0.849) and stickiness (r = 0.958) of texture. Toyo taste value was highly correlated with consumer acceptance (r = 0.726), but eating quality measurement was not correlated with consumer acceptance (r = −0.018). Partial least square regression between mechanical parameters and consumer acceptance ratings showed which mechanical measurements have more influence on the determination of consumer acceptance of frozen‐cooked rice. There were two positive instrumental indicators – ratio of cracked kernel and stickiness – and two negative ones – breakdown of rapid viscometer analysis and hardness. These mechanical parameters can be used as primary indices to screen rice varieties for high quality frozen‐cooked rice.Practical ApplicationsThere were many mechanical indicators in determining the quality of raw rice and cooked rice. However, there was no study that indicates that mechanical indicators are the key factors representing consumer acceptance of frozen‐cooked rice in the overall aspects of these indicators. Four mechanical indicators – ratio of cracked kernel, stickiness, hardness and breakdown of rapid viscosity analysis – showed higher influence on the consumer acceptance of frozen‐cooked rice. Applying these indicators would reduce the amount of cultivar screening efforts to select proper rice varieties for frozen‐cooked rice processing.
Evaluation of the Dynamics of Microbiological Quality in Lightly Pickled Napa Cabbages During Manufacture
Authors: Masuda Kazuya , Yamamoto Shiori , Kubota Kunihiro , Kurazono Hisao , Makino Sou‐ichi , Kasuga Fumiko , Igimi Shizunobu , Asakura Hiroshi 
Published: April 2015

AbstractFollowing a large outbreak of Shiga toxin‐producing Escherichia coli (STEC) O157 infection in 2012, the prerequisite program for the production of pickles in Japan was revised to include disinfection with sodium hypochlorite (NaClO). Here, we examined the indicator bacterial counts, incidence of STEC and Salmonella spp. (by polymerase chain reaction [PCR] screening), and bacterial community composition (by 16S rRNA pyrosequencing analysis) from the intermediate products and the related facilities at a collaborative factory to evaluate the dynamics of microbial quality in lightly pickled vegetables during the manufacturing process following the revised program. Plate counts showed a significant reduction in coliform counts throughout processing, whereas the reduction in total viable counts was relatively less than that of coliforms. No STEC and Salmonella spp. were recovered from any of the samples. 16S rRNA pyrosequencing analysis revealed the process‐by‐process alteration of bacterial community composition in which the yields of Pseudomonas spp. were drastically affected by soaking in high concentration of NaCl. In summary, we demonstrate that the revised prerequisite program is indeed functional to reduce the microbial risks.Practical ApplicationsFresh or minimally processed produce are common vehicles of foodborne pathogens that have been responsible for several outbreaks worldwide. Through the use of indicator bacterial counts in combination with a metagenomic approach, we could trace the process‐by‐process dynamics of bacterial community composition. Information and relief provided to manufacturers/consumers could help improve public health and food safety.
Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory‐related synaptic plasticity in the mouse hippocampus
Authors: Jung Gangsoo , Kim Eun‐Jung , Cicvaric Ana , Sase Sunetra , Gröger Marion , Höger Harald , Sialana Fernando Jayson , Berger Johannes , Monje Francisco J. , Lubec Gert 
Published: April 2015

AbstractDrebrin an actin‐bundling key regulator of dendritic spine genesis and morphology, has been recently proposed as a regulator of hippocampal glutamatergic activity which is critical for memory formation and maintenance. Here, we examined the effects of genetic deletion of drebrin on dendritic spine and on the level of complexes containing major brain receptors. To this end, homozygous and heterozygous drebrin knockout mice generated in our laboratory and related wild‐type control animals were studied. Level of protein complexes containing dopamine receptor D1/dopamine receptor D2, 5‐hydroxytryptamine receptor 1A (5‐HT1AR), and 5‐hydroxytryptamine receptor 7 (5‐HT7R) were significantly reduced in hippocampus of drebrin knockout mice whereas no significant changes were detected for GluR1, 2, and 3 and NR1 as examined by native gel‐based immunoblotting. Drebrin depletion also altered dendritic spine formation, morphology, and reduced levels of dopamine receptor D1 in dendritic spines as evaluated using immunohistochemistry/confocal microscopy. Electrophysiological studies further showed significant reduction in memory‐related hippocampal synaptic plasticity upon drebrin depletion. These findings provide unprecedented experimental support for a role of drebrin in the regulation of memory‐related synaptic plasticity and neurotransmitter receptor signaling, offer relevant information regarding the interpretation of previous studies and help in the design of future studies on dendritic spines.image
We examined effect of genetic deletion of drebrin, which an actin‐bundling key regulator of dendritic spine genesis and morphology, on dendritic spine density, maturity, level of complexes containing major brain receptors and also, in synaptic plasticity. These findings support for a role of drebrin in the regulation of memory‐related synaptic plasticity and neurotransmitter receptors signaling in dendritic spines.
Medial gastrocnemius muscle growth during adolescence is mediated by increased fascicle diameter rather than by longitudinal fascicle growth
Authors: Weide Guido , Huijing Peter A. , Maas Josina C. , Becher Jules G. , Harlaar Jaap , Jaspers Richard T. 
Published: April 2015

AbstractUsing a cross‐sectional design, the purpose of this study was to determine how pennate gastrocnemius medialis (GM) muscle geometry changes as a function of adolescent age. Sixteen healthy adolescent males (aged 10–19 years) participated in this study. GM muscle geometry was measured within the mid‐longitudinal plane obtained from a 3D voxel‐array composed of transverse ultrasound images. Images were taken at footplate angles corresponding to standardised externally applied footplate moments (between 4 Nm plantar flexion and 6 Nm dorsal flexion). Muscle activity was recorded using surface electromyography (EMG), expressed as a percentage of maximal voluntary contraction (%MVC). To minimise the effects of muscle excitation, EMG inclusion criteria were set at < 10% of MVC. In practice, however, normalised EMG levels were much lower. For adolescent subjects with increasing ages, GM muscle (belly) length increased due to an increase in the length component of the physiological cross‐sectional area measured within the mid‐longitudinal plane. No difference was found between fascicles at different ages, but the aponeurosis length and pennation angle increased by 0.5 cm year−1 and 0.5 ° per year, respectively. Footplate angles corresponding to externally applied 0 and 4 Nm plantarflexion moments were not associated with different adolescent ages. In contrast, footplate angles corresponding to externally applied 4 and 6 Nm dorsal flexion moments decreased by 10 ° between 10 and 19 years. In conclusion, we found that in adolescents' pennate GM muscles, longitudinal muscle growth is mediated predominantly by increased muscle fascicle diameter.