bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Unbearable Lightness of Casablanca: In Defense of a Committed Cosmopolitanism
Authors: Brence Steven 
Published: December 2014

ABSTRACT
Via exposition of the classic Hollywood film Casablanca, and with reference to Milan Kundera's novel The Unbearable Lightness of Being, the nature of cosmopolitanism is critically explored. Both the propagandistic function of the film, justifying American entry into World War II, and the qualified love story at its center are explicated to support a “committed” cosmopolitanism, an understanding of that disposition that would distinguish it from a cynical neutrality, at a political level, and from a self- justifying conception of romantic love, on an interpersonal level.
Why Pragmatists Should Not Be Cyborgs
Authors: Magada-Ward Mary 
Published: December 2014

ABSTRACT
By examining the influential work of the historian of science and feminist theorist Donna Haraway, I argue for the pragmatic importance of respecting the distinctions between myth and science and between fact and fiction. My aim is to show that the classical pragmatism of Peirce and James provides a via medina between the enforcement of entrenched dichotomies and the morass of complete boundary confusion.
Expression and Characterization of Two β-Galactosidases from Klebsiella pneumoniae 285 in Escherichia coli and their Application in the Enzymatic Synthesis of Lactulose and 1-Lactulose
Authors: Wang He , Yang Ruijin , Jiang Xiaoyan , Hua Xiao , Zhao Wei , Zhang Wenbin , Chen Xuan 
Published: December 2014

Abstract
The two genes lacZ1 and lacZ2 from Klebsiella pneumoniae 285, encoding β-galactosidase isoenzymes II and III (KpBGase-II and -III), were each cloned downstream of a T7 promoter for expression in Escherichia coli BL21(DE3), and the resulting recombinant enzymes were characterized in detail. The optimum temperature and pH value of KpBGase-II were 40 °C and 7.5, and those of KpBGase-III were 50 °C and 8.0, respectively. KpBGase-III was more stable than KpBGase-II at higher temperature (>60°C). Both β-galactosidases were more active towards o-nitrophenyl-β- D-galactopyranoside as compared to lactose. The enzymatic synthesis of lactulose and 1-lactulose catalyzed by KpBGase-II and KpBGase-III was investigated. Using 400 g/L lactose and 200 g/L fructose as substrates, the resulting lactulose and 1-lactulose yields with KpBGase-II were 6.2 and 42.3 g/L, while those with KpBGase-III were 5.1 and 23.8 g/L, respectively. KpBGase-II has a potential for the production of 1-lactulose from lactose and fructose. Like other β-galactosidases, the two isozymes catalyze the transgalactosylation in the presence of fructose establishing the β-(1→1) linkage.
Ratjadone C-Mediated Nuclear Accumulation of HDAC4: Implications on Runx2-Induced Osteoblast Differentiation of C3H10T1/2 Mesenchymal Stem Cells
Authors: Mu Ping , Deepak Vishwa , Kang Liheng , Jiang Qing , Liu Rong , Meng Lingyi , Zhang Zhongli , Zeng Xianlu , Liu Wenguang 
Published: December 2014

Abstract
Histone deacetylases (HDACs) are a group of enzymes that deacetylate ε-N-acetyl lysine residues of histone and non-histone proteins and play an important role in gene regulation. HDAC4, a class-IIa HDAC, has been reported to shuttle between nucleus and cytoplasm in response to various cellular stimuli. The nucleo-cytoplasmic shuttling of HDAC4 is critical, and an anomalous nuclear localization might affect the cellular differentiation program. While the subcellular localization of HDAC4 has been reported to be vital for myoblast differentiation and chondrocyte hypertrophy, nuclear accumulation of HDAC4 during Runx2-induced osteoblast differentiation of stem cells has not been characterized. Ratjadone C is a natural compound that inhibits the nuclear export of proteins. Here, we show that Runx2 is a more potent transcription factor than Osterix in inducing osteoblast differentiation. Under the influence of ratjadone C, HDAC4 is retained in the nucleus and co-localizes with Runx2. However, forced nuclear accumulation of HDAC4 by ratjadone C or overexpression of the nuclear resident form of HDAC4 does not inhibit osteoblast differentiation, suggesting that the Runx2- induced osteogenic program of C3H10T1/2 cells is not affected by HDAC4. Even though phosphorylation of HDAC4 affects its compartmentalization and the stemness of progenitor cells, we found that total HDAC4 and phosphorylated HDAC4 remain cytoplasmic under both osteogenic and nonosteogenic conditions. Collectively, this work demonstrates that, regardless of the nucleo-cytoplasmic presence of HDAC4, the Runx2-induced osteoblast differentiation program of C3H10T1/2 cells remains unaffected. Additionally, the ratjadone C-mediated nuclear retention assay can potentially be used as a screening tool to identify novel regulatory mechanisms of HDAC4 and its functional partners in various pathophysiological conditions.
Cardioprotective Effect of Saffron Extracts against Acute Doxorubicin Toxicity in Isolated Rabbit Hearts Submitted to Ischemia-Reperfusion Injury
Authors: Chahine Nathalie , Makhlouf Hassane , Duca Laurent , Martiny Laurent , Chahine Ramez 
Published: December 2014

Abstract
Doxorubicin (DOX) is an anthracycline antibiotic routinely used as a chemotherapeutic agent for the treatment of solid tumours. However, DOX possesses an acute and cumulative cardiotoxicity due to free radical production. The present study was designed to investigate the possible protective effects of saffron (Crocus sativus) extracts against DOX-induced acute cardiotoxicity in isolated rabbit hearts submitted to 30 min global ischemia followed by 40 min reperfusion. DOX was delivered during reperfusion, without or with saffron given 5 min before ischemia or at reperfusion. Cardiodynamic, biochemical, and histopathological parameters were determined. In addition, to determine the expression of the AKT/mTOR/4EBP1 pathway, the levels of p38 MAPK and cardiac troponin T in heart homogenates were visualized by Western blotting. DOX administration during 40 min of reperfusion increased ischemic tissue damage, but did not act synergistically. Administration of saffron extracts during the first minutes of reperfusion significantly reduced oxidative myocardial damage, but was less effective when given before ischemia. Subsequent Western blot analysis revealed that saffron administration preserved cardiac troponin T proteins, inhibited the p38 MAPK pathway, and activated the AKT/mTOR/4EBP1 pathway in reperfusion- and DOX-treated rabbit hearts. In conclusion, saffron extracts, acting through antioxidant and antiapoptotic mechanisms, exhibited a protective effect against DOX-induced cardiotoxicity under ischemic condition.
Espace, temps et théorie du capital chez Henri Lefebvre et Marx
Authors: Gaudreau Louis 
Published: December 2014

Ce texte propose une réflexion sur la production capitaliste de l’espace. Il présente la théorie d’Henri Lefebvre sur l’espace et tente de mettre en lumière la contribution originale de cet auteur à la compréhension du rapport entre temps et espace dans la reproduction du capitalisme. L’analyse porte plus particulièrement sur le concept d’espace abstrait développé par Lefebvre, dont on retrouve une formulation implicite dans les travaux de Marx, et qui révèle le rôle actif joué par la spatialité dans le procès de valorisation capitaliste. Le concept lefebvrien d’espace abstrait jette ainsi les bases d’une remise en question du primat accordé au temps dans la tradition d’analyse critique du capitalisme. Le texte se conclut par de brèves réflexions sur l’actualité d’une telle conception de l’espace pour saisir la récente financiarisation du capital.
North‐south asymmetry of the high‐latitude thermospheric density: IMF BY effect
Authors: Yamazaki Yosuke , Kosch Michael J. , Sutton Eric K. 
Published: December 2014

AbstractPrevious studies have established that the y component of the interplanetary magnetic field (IMF By) plays a role in the north‐south asymmetry of the high‐latitude plasma convection and wind. The effect of the positive/negative IMF By in the Northern Hemisphere resembles the effect that the negative/positive IMF By would have in the Southern Hemisphere. In this study, we demonstrate that the IMF By effect can also contribute to the hemispheric asymmetry of the thermospheric density. We use high‐accuracy air drag measurements from the CHAllenging Minisatellite Payload (CHAMP) satellite and SuperMAG AE index during the period 2001–2006 to examine the response of the high‐latitude thermospheric density to geomagnetic activity. Our statistical analysis reveals that the density response at 400 km is greater in the Southern Hemisphere under positive IMF By conditions, and greater in the Northern Hemisphere under negative IMF By conditions. The results suggest that the IMF By effect needs to be taken into account in upper atmospheric modeling for an accurate description of high‐latitude densities during periods of enhanced geomagnetic activity.
Microwave‐Promoted Synthesis of Smart Superporous Hydrogel for the Development of Gastroretentive Drug Delivery System
Authors: Goganian Amir Mohammad , Hamishehkar Hamed , Arsalani Nasser , Khiabani Hanie Khaksar 
Published: December 2014

ABSTRACTSmart superporous hydrogels (SPHs) based on dimethylaminoethyl methacrylate and acrylamide monomers with and without magnetic nanoparticles (MNPs) were synthesized via a microwave procedure. The synthesized samples were confirmed by various techniques such as Fourier transform spectroscopy, x‐ray diffraction, thermogravimetric analysis, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy. The parameters such as pH, irradiation time, and MNPs content on the swelling behavior of products were studied. The results of swelling studies in artificial gastric and intestine media exhibited a higher swelling ratio of SPHs in lower pH, confirming smart performance of SPHs for gastroretentive drug delivery (GDD). The metronidazole (MTZ) was used as an effective antibiotic administered in peptic ulcer therapy. The in vitro release studies showed that the presence of MNPs into the hydrogel network provided the sustained release pattern for MTZ. It was concluded that our developed SPHs and MSPHs fabricated via a facile method have potential to be used in GDD.
Chirality‐Assisted Ring‐Like Aggregation of Aβ(1–40) at Liquid–Solid Interfaces: A Stereoselective Two‐Step Assembly Process
Authors: Gao Guanbin , Zhang Mingxi , Lu Pei , Guo Guanlun , Wang Dong , Sun Taolei 
Published: December 2014

AbstractMolecular chirality is introduced at liquid–solid interfaces. A ring‐like aggregation of amyloid Aβ(1–40) on N‐isobutyryl‐L‐cysteine (L‐NIBC)‐modified gold substrate occurs at low Aβ(1–40) concentration, while D‐NIBC modification only results in rod‐like aggregation. Utilizing atomic force microscope controlled tip‐enhanced Raman scattering, we directly observe the secondary structure information for Aβ(1–40) assembly in situ at the nanoscale. D‐ or L‐NIBC on the surface can guide parallel or nonparallel alignment of β‐hairpins through a two‐step process based on electrostatic‐interaction‐enhanced adsorption and subsequent stereoselective recognition. Possible electrostatic interaction sites (R5 and K16) and a chiral recognition site (H14) of Aβ(1–40) are proposed, which may provide insight into the understanding of this effect.
Regioselektive katalytische asymmetrische C‐Alkylierung von Isoxazolinonen durch basenfreie Palladacyclus‐katalysierte direkte 1,4‐Addition
Authors: Hellmuth Tina , Frey Wolfgang , Peters René 
Published: December 2014

AbstractIsoxazolinone bilden eine Klasse von Heterocyclen, die häufig bei der Entwicklung von potentiellen neuen Wirkstoffen Verwendung findet. Die cyclische Oximester‐Einheit ist außerdem synthetisch wertvoll, da sie funktionelle “Stellschrauben” beinhaltet, die den Zugang zu einer Vielzahl von wertvollen Verbindungsklassen ermöglichen, welche durch andere Methoden nur schwer zugänglich sind. Dennoch sind asymmetrische Methoden zu chiralen Isoxazolinonen offenkundig selten. Hiermit stellen wir die erste katalytische, asymmetrische Alkylierung von Isoxazolinonen zur Bildung von all‐C‐substituierten quartären Stereozentren vor. Die gegenwärtigen Studien wurden durch die Frage nach der Kontrolle der Regioselektivität aufgrund der Konkurrenz von verschiedenen nukleophilen Positionen angetrieben. Die Untersuchung einer direkten 1,4‐Addition ließ erkennen, dass ein sterisch anspruchsvoller palladacyclischer Katalysator die Reaktivität in Abwesenheit einer Base nahezu ausschließlich zum nukleophilen C‐Atom steuert, während gleichzeitig hohe Enantioselektivitäten und TONs von bis zu 1900 erreicht werden.
Impact of lymph node ratio on survival in patients with pancreatic and periampullary cancer
Authors: Tol J A M G , Brosens L A A , van Dieren S , van Gulik T M , Busch O R C , Besselink M G H , Gouma D J 
Published: December 2014

Abstract

Background
According to some studies, the number of lymph nodes with metastases in relation to the total number of removed lymph nodes, the lymph node ratio (LNR), is one of the most powerful predictors of survival after resection in patients with pancreatic cancer. However, contradictory results have been reported, and small sample sizes of the cohorts and different definitions of a microscopic positive resection margin (R1) hamper the interpretation of data.

Methods
The predictive value of LNR for 3-year survival was assessed using a Cox proportional hazards model. From 1992 to 2012, all patients with pancreatic and periampullary cancer operated on with pancreatoduodenectomy were selected from a database. Clinicopathological characteristics were analysed. Microscopic positive resection margin was defined as the microscopic presence of tumour cells within 1 mm of the margins. A nomogram was created.

Results
Some 760 patients were included. Predictive factors for death in 350 patients with pancreatic ductal adenocarcinoma included in the nomogram were: R1 resection (hazard ratio (HR) 1·55, 95 per cent c.i. 1·07 to 2·25), poor tumour differentiation (HR 2·78, 1·40 to 5·52), LNR above 0·18 (HR 1·75, 1·13 to 2·70) and no adjuvant therapy (HR 1·54, 1·01 to 2·34). The C statistic was 0·658 (0·632 to 0·698), and calibration was good (Hosmer–Lemeshow χ2 = 5·67, P =0·773). LNR and poor tumour differentiation (HR 4·51 and 3·30 respectively) were also predictive in patients with distal common bile duct (CBD) cancer. LNR, R1 resection and jaundice were predictors of death in patients with ampullary cancer (HR 7·82, 2·68 and 1·93 respectively).

Conclusion
LNR is a common predictor of poor survival in pancreatic, distal CBD and ampullary cancer.
Gradient‐Direction‐Pattern Transform for Automated Measurement of Oil Drops in Images of Multiphase Dispersions
Authors: Rojas‐Domínguez Alfonso , Holguín‐Salas Alehlí , Galindo Enrique , Corkidi Gabriel 
Published: December 2014

AbstractThe automated detection and measurement of oil drops in multiphase fermentation systems are important for mass transfer analysis. A novel computer technique for automated detection of oil drops in images is presented in the context of a stirred tank containing a three‐phase water‐oil‐air dispersion. The technique is an original feature extraction transform designed for the detection of objects with a characteristic appearance. The proposed transform, denominated gradient‐direction‐pattern (GDP) transform, utilizes naturally occurring patterns in the orientation of the local gradient appearing in test images. The GDP transform was used to demonstrate the feasibility of automatically estimating oil drop‐size unbiased distributions which is an important task in the chemical and other related industries.
Enantioselective Michael Addition of Water
Authors: Chen Bi‐Shuang , Resch Verena , Otten Linda G. , Hanefeld Ulf 
Published: December 2014

AbstractThe enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β‐hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti‐stereochemistry.
Conformational Dependence of Through‐Space Tellurium–Tellurium Spin–Spin Coupling in Peri‐Substituted Bis(Tellurides)
Authors: Knight Fergus R. , Diamond Louise M. , Arachchige Kasun S. Athukorala , Sanz Camacho Paula , Randall Rebecca A. M. , Ashbrook Sharon E. , Bühl Michael , Slawin Alexandra M. Z. , Woollins J. Derek 
Published: December 2014

AbstractThree related series of peri‐substituted bis(tellurides) bearing naphthalene, acenaphthene and acenaphthylene backbones (Nap/Acenap/Aceyl(TeY)2 (Nap=naphthalene‐1,8‐diyl N; Acenap=acenaphthene‐5,6‐diyl A; Aceyl=acenaphthylene‐5,6‐diyl Ay; Y=Ph 1; Fp 2; Tol 3; An‐p­ 4; An‐o­ 5; Tp 6; Mes 7; Tip 8) have been synthesised and their solid‐state structures determined by X‐ray crystallography. Molecular conformations were classified as a function of the two C9‐C‐Te‐C(Y) dihedral angles (θ); in the solid all members adopt AB or CCt configurations, with larger Te(aryl) moieties exclusively imposing the CCt variant. Exceptionally large J(125Te,125Te) spin–spin coupling constants between 3289–3848 Hz were obtained for compounds substituted by bulky Te(aryl) groups, implying these species are locked in a CCt‐type conformation. In contrast, compounds incorporating smaller Te(aryl) moieties are predicted to be rather dynamic in solution and afford much smaller J values (2050–2676 Hz), characteristic of greater populations of AB conformers with lower couplings. This conformational dependence of through‐space coupling is supported by DFT calculations.
Practical Route to the Left Wing of CTX1B and Total Syntheses of CTX1B and 54‐deoxyCTX1B
Authors: Yamashita Shuji , Takeuchi Katsutoshi , Koyama Takuya , Inoue Masayuki , Hayashi Yujiro , Hirama Masahiro 
Published: December 2014

AbstractCiguatoxins, the principal causative agents of ciguatera seafood poisoning, are extremely large polycyclic ethers. We report herein a reliable route for constructing the left wing of CTX1B, which possesses the acid/base/oxidant‐sensitive bisallylic ether moiety, by a 6‐exo radical cyclization/ring‐closing metathesis strategy. This new route enabled us to achieve the second‐generation total synthesis of CTX1B and the first synthesis of 54‐deoxyCTX1B.
ChemInform Abstract: Thermoelectric Properties of p‐Type Semiconducting NaB5C with Hexaboride‐Type Structure, Compared to Layered MB2C2 (M: La, Ce).
Authors: Guersoy Murat , Hempel Sabine , Reitz Andreas , Hofmann Kathrin , Albert Barbara 
Published: December 2014

AbstractNaB5C is prepared by solid state reaction of the elements in the molar ratio of Na:B:C = 6:5:1 (sealed boronated Ta tubes in evacuated quartz ampoule, 1000 °C, 6‐8 h) and densified by high‐pressure spark plasma sintering (923 K, 100 MPa, 90 min).
ChemInform Abstract: Ferrimagnetism in the High Pressure 6H‐Perovskite BaCrO3.
Authors: Arevalo‐Lopez Angel M. , Reeves Simon J. , Attfield J. Paul 
Published: December 2014

AbstractThe 6‐layered hexagonal polymorph of 6H‐BaCrO3 is prepared by hot isostatic pressing of Ba3Cr2O8 (from BaCO3 and Cr2O3, 1000 °C, 12 h) and Cr2O3 in the molar ratio of 2:1 (multianvil press, 900 °C, 9 GPa, 30 min).
ChemInform Abstract: Charge‐Order Melting in Charge‐Disproportionated Perovskite CeCu3Fe4O12.
Authors: Yamada Ikuya , et al. et al. 
Published: December 2014

AbstractThe title compound is prepared by high temperature/high pressure reaction of a precursor of nominal composition CeCu3Fe4O11 and KClO4 in a molar ratio of 2:1 (Pt capsule, 15 GPa, 1473 K, 30 min).
ChemInform Abstract: Tetrapalladium‐Containing Polyoxotungstate [PdII4 (α‐P2W15O56)2] 16—: A Comparative Study.
Authors: Izarova Natalya V. , Maksimovskaya Raisa I. , Willbold Sabine , Koegerler Paul 
Published: December 2014

AbstractNa16 [Pd4 (α‐P2W15O56)2] ·71H2O is synthesized from a mixture of Na12[α‐P2W15O56] dissolved in 0.5 M AcONa buffer (pH 4.2) and solid Pd(NO3)2 (25 °C, 1 h, 55% yield).
ChemInform Abstract: RE6Pd13Zn4 (RE: La—Nd, Sm, Gd, Tb) — New Palladium‐Rich Phases with Pd@RE6 Octahedra in bcc Packing.
Authors: Gerke Birgit , Janka Oliver , Poettgen Rainer 
Published: December 2014

AbstractLn6Pd13Zn4 (Ln: La—Nd, Sm, Gd, Tb) intermetallics are prepared from the elements in the ratio Ln:Pd:Zn = 1:2:1 (sealed Nb ampoules, 1.
ChemInform Abstract: Synthesis of N‐Aryl Substituted, Five‐ and Six‐Membered Azacycles Using Aluminum‐Amide Complexes.
Authors: Korbad Balaji L. , Lee Sang‐Hyeup 
Published: December 2014

AbstractTreatment of cyclic ethers such as (I), (IV), (VI), and (VIII) with dimethylaluminum‐amide reagents, derived from aryl amines (II) and trimethylaluminum, affords the corresponding azacycles (III), (V), (VII), and (IX), resp., in good yields.
ChemInform Abstract: InCl3‐Mediated Eco‐Friendly Three‐Component Domino Reaction for Synthesis of Highly Functionalized Triazolylspiroxindolinopyrans and Triazolylpyrans under Solvent‐Free Conditions.
Authors: Kamalraja Jayabal , Murugasan Potharaj , Perumal Paramasivan Thirumalai 
Published: December 2014

AbstractThe title compounds are designed by combining three biologically important core moieties in a single molecule.
ChemInform Abstract: Soft Propargylic Deprotonation: Designed Ligand Enables Au‐Catalyzed Isomerization of Alkynes to 1,3‐Dienes.
Authors: Wang Zhixun , Wang Yanzhao , Zhang Liming 
Published: December 2014

AbstractAlthough the isomerizations of the terminal alkynes (XIV) and (XVI) proceed very efficiently, no diene product is observed upon reaction of the terminal alkyne analogue of (VIII) without the phenyl group.
ChemInform Abstract: Reduced Graphene Oxide as a Recyclable Catalyst for Dehydrogenation of Hydrazo Compounds.
Authors: Bai Li‐Sha , Gao Xiao‐Min , Zhang Xuan , Sun Fei‐Fei , Ma Ning 
Published: December 2014

AbstractReduced graphene oxide efficiently catalyzes the aerobic oxidative dehydrogenation of aromatic hydrazo compounds.
ChemInform Abstract: Sonogashira Couplings Catalyzed by Collaborative (N‐Heterocyclic Carbene)‐Copper and ‐Palladium Complexes.
Authors: Gallop Christopher W. D. , Chen Ming‐Tsz , Navarro Oscar 
Published: December 2014

AbstractThis user‐friendly protocol for the Sonogashira coupling needs only very low loadings of the corresponding catalysts, and does not require the use of an anhydrous solvent or an inert atmosphere.
ChemInform Abstract: Copper(I)‐Catalyzed Multicomponent Reaction Providing a New Access to Fully Substituted Thiophene Derivatives.
Authors: Jiang Bo , Tu Xing‐Jun , Wang Xue , Tu Shu‐Jiang , Li Guigen 
Published: December 2014

AbstractCondensation of α‐thiocyanate ketones with indole‐2,3‐diones gives aroylethanethiolates (IV), which readily undergo a Cu(I)‐catalyzed three‐component reaction with terminal alkynes and tosylazides to form highly functionalized thiophene derivatives through [3 + 2] cycloaddition of in situ generated azaheterocumulenes.
ChemInform Abstract: Rh(III)‐Catalyzed C—H Activation/Cyclization of Indoles and Pyrroles: Divergent Synthesis of Heterocycles.
Authors: Zhang Yan , Zheng Jing , Cui Sunliang 
Published: December 2014

AbstractA new strategy is developed which allows the reaction of the title compounds with alkynes, alkenes, and diazo compounds.
ChemInform Abstract: An Efficient and Facile Synthesis of Benzimidazo[1,2‐a]benzimidazoles via Copper‐Catalyzed Domino Addition/Double Cyclization
Authors: Yuan Guodong , Liu Haiquan , Gao Jilong , Xu Hongjuan , Jiang Liu , Wang Xiaoxia , Lv Xin 
Published: December 2014

Abstractof bis(o‐haloaryl)carbodiimides with primary amines
ChemInform Abstract: Synthesis of Functionalized N‐Triazolyl Maleimides.
Authors: Stefani Helio A. , Ferreira Fernando P. , Ali Bakhat , Pimenta Daniel C. 
Published: December 2014

AbstractN‐Triazolyl maleimides (III) are prepared by copper catalyzed 1,3‐cycloaddition of enantiopure N‐propargylpyrrole (I) with various azides.