bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome‐wide study of OsWRKY gene in Oryza sativa subsp. japonica
Authors: Meher Jhumishree , Narware Jeetu , Masurkar Prahlad 
Published: July 2024

AbstractWRKY transcription factor (TF) family is well known to govern essential physiological functioning as well as regulate plant response to biotic and abiotic stress. In this study, we have identified 108 OsWRKY genes in the genome of Oryza sativa subsp. japonica, using the updated genomic data from the Rice Annotation Project Database and Oryzabase, which were further used to conduct the phylogenetic study, motif analysis, gene structure analysis, chromosomal mapping, and prediction of sub‐cellular localization. The multiple sequence alignment OsWRKY proteins revealed the presence of nine different types of alterations in the conserved heptapeptide sequence WRKYGQK associated with 19 OsWRKY genes. Physiochemical analysis discloses the hydrophobic amino acid‐rich, thermally stable, and polar nature of OsWRKY proteins. These genes were noted as highly conserved between the two cultivated sub‐species of Oryza sativa, that is Indica and japonica type. Additionally, from motif analysis, we have found a new motif, which was categorized as hAT family C‐terminal dimerization region associated with four members of group IIc. We have identified 21 stress‐responsive OsWRKY genes, and their significance to the different biotic and abiotic stress‐mediated cascades was further evaluated by analysing 1500 kb upstream sequences and this disclosed the presence of important phytohormone‐responsive cis‐elements in the OsWRKY gene, suggesting its direct involvement in defence against a wide range of external stressors and these 21 OsWRKY genes are tentatively listed as possible candidates for more study.
Supply chain risks and geographical supplier distribution strategy
Authors: Zhuo Qianru , Qin Libin , Liu Wei , Liu Ying , You Jiaxing 
Published: July 2024

AbstractThis study empirically examines the impact of supply chain risks on the corporate strategy of the geographical distribution of suppliers, by employing text analysis to procure firm‐level supply chain risk data. The findings indicate that, as supply chain risks intensify, firms are inclined to opt for geographically closer suppliers. Heterogeneity studies suggest that the effect of supply chain risks on the selection of geographically proximate suppliers is more pronounced within firms characterised by intense competition, low supplier concentration, low switching costs and in non‐state‐owned enterprises. Further analysis identifies that the supply chain risks, which drive strategies for firms to utilise a geographically proximate supplier distribution, stem from various sources. Each of these sources varies in its impact on a firm's strategies. Tests of economic consequences reveal that, in scenarios of heightened supply chain risks, firms' strategic geographic adjustments in supplier selection can favourably impact their supply chain management efficiency and operational risk.
Federal judge ideology, securities class action litigation, and stock price crash risk
Authors: Cui Xiaoyu , Han Jianlei , Kim Jeong Bon , Qi Baolei 
Published: July 2024

AbstractThis study investigates whether and how federal judge ideology affects firm‐specific stock price crash risk. Using a comprehensive sample of US firms, we find a decline in the likelihood of future stock price crashes for firms headquartered in more liberal circuits. In identifying potential mechanisms, we show that liberal judge ideology reduces information opacity, risk‐taking behaviours and overinvestment, and thus curbs stock price crash risk. Furthermore, the curbing effect is more salient for firms with poor monitoring quality and those in low social capital areas. Overall, this study elucidates how federal judge ideology affects capital markets.
Cone‐beam computed tomography‐based descriptive classification for transverse root fracture
Authors: Saini Aakriti , Sharma Sidhartha , Kumar Vijay , Chawla Amrita , Gupta Shalini , Kahler Bill , Logani Ajay 
Published: July 2024

AbstractTransverse root fracture (TRF) is classified as a cervical, middle or apical third root fracture on a periapical radiograph. The International Association of Dental Traumatology (IADT) suggests that cone‐beam computed tomography (CBCT) should be considered, when conventional radiographs provide ‘insufficient’ information for diagnosis and treatment planning. Considering that CBCT can divulge additional information, it would be beneficial to have a clinically pertinent three‐dimensional classification for TRF. The proposed alphanumeric classification includes the traumatised tooth number, describes the number of TRF, the facial and lingual location of each fracture line on the anatomic root, and its position relative to the crest of the alveolar bone. Further, diastasis, displacement of the coronal fragment and status of the alveolar bone at the site of TRF are also documented. This comprehensive classification system would provide a standard format for reporting, aid in referral communication and can be applied for future outcome studies on TRF.
Certainty in holistic thinking and responses to contradiction: Dialectical proverbs, counter‐attitudinal change and ambivalence
Authors: Santos David , Requero Blanca , Moreno Lorena , Briñol Pablo , Petty Richard 
Published: July 2024

AbstractThe present research examined whether consideration of individuals' certainty in their holism can enhance the ability of this individual difference to predict how they respond to contradiction‐relevant outcomes. Across four studies, participants first completed a standardized measure of holistic‐analytic thinking. Then, they rated how certain they were in their responses to the holism scale or were experimentally induced to feel high or low certainty. Next, participants were exposed to dialectical proverbs (Study 1a and 1b), to a counter‐attitudinal change induction (Study 2), or to a paradigm of attitudinal ambivalence (Study 3). Results revealed that participants with higher certainty in their holistic thinking exhibited higher preference for dialectical proverbs (Study 1a and 1b), changed their attitude less following a counter‐attitudinal task (Study 2) and showed weaker correspondence between objective and subjective ambivalence (Study 3). Beyond examining new domains and discovering novel findings, the present work was designed to be the first to show moderation of previously identified effects in the domain of holistic thinking and responses to contradiction.
LncRNA HULC augments high glucose‐associated pancreatic cancer progression and drug resistance by enhancing YAP activity and autophagy
Authors: Sharma Ankita , Chowdhury Shibasish , Mukherjee Sudeshna , Chowdhury Rajdeep 
Published: July 2024

AbstractBackground Information: One of the confounding factors in pancreatic cancer (PC) pathogenesis is hyperglycemia. The molecular mechanism by which high glucose (HG) influences PC severity is poorly understood. Our investigation delved into the impact of lncRNA highly upregulated in liver cancer (HULC) and its interaction with yes‐associated protein (YAP) in regulating the fate of pancreatic ductal adenocarcinoma cells (PDAC) under HG‐induced conditions. PDAC cells were cultured under normal or HG conditions. We thereafter measured the effect of HG on the viability of PDAC cells, their migration potential and drug resistance properties. The lncRNAs putatively dysregulated in PC and diabetes were shortlisted by bioinformatics analysis followed by wet lab validation of function. Results: HG led to enhanced proliferation and drug refractoriness in PDAC cells. HULC was identified as one of the major deregulated lncRNAs following bioinformatics analysis. HULC was found to regulate the expression of the potent transcriptional regulator – YAP through selective histone modifications at the YAP promoter. siRNA‐mediated ablation of HULC resulted in a concurrent decrease in YAP transcriptional activity. Importantly, HULC and YAP were found to co‐operatively regulate the cellular homeostatic process autophagy, thus inculcating drug resistance and proliferative potential in PDAC cells. Moreover, inhibition of autophagy or YAP led to a decrease in HULC levels, suggesting the existence of an inter‐regulatory feedback loop. Conclusions: We observed that HG triggers aggressive properties in PDAC cells. Mechanistically, up‐regulation of lncRNA HULC resulted in activation of YAP and differential regulation of autophagy coupled to increased proliferation of PDAC cells. Significance: Inhibition of HULC and YAP may represent a novel therapeutic strategy for PDAC. Furthermore, this study portrays the intricate molecular interplay between HULC, YAP and autophagy in PDAC pathogenesis.
Anti‐LINGO‐1 treatment restores myelination of corticospinal tract neurons and improves functional recovery after stroke
Authors: Strecker Jan‐Kolja , Schmidt‐Pogoda Antje , Diederich Kai , Zaremba Dario , Wieters Frederique , Beuker Carolin , Koecke Mailin Hannah Marie , Straeten Frederike Anne , Wiendl Heinz , Minnerup Jens 
Published: July 2024

AbstractDemyelination of corticospinal tract neurons contributes to long‐term disability after cortical stroke. Nonetheless, poststroke myelin loss has not been addressed as a therapeutic target, so far. We hypothesized that an antibody‐mediated inhibition of the Nogo receptor‐interacting protein (LINGO‐1, leucine‐rich repeat and immunoglobulin domain‐containing Nogo receptor‐interacting protein) may counteract myelin loss, enhance remyelination and axonal growth, and thus promote functional recovery following stroke. To verify this hypothesis, mice were subjected to photothrombotic stroke and received either an antibody against LINGO‐1 (n = 19) or a control treatment (n = 18). Behavioral tests were performed to assess the effects of anti‐LINGO‐1 treatment on the functional recovery. Seven weeks after stroke, immunohistochemical analyses were performed to analyze the effect of anti‐LINGO‐1 treatment on myelination and axonal loss of corticospinal tract neurons, proliferation of oligodendrocytes and neurogenesis. Anti‐LINGO‐1 treatment resulted in significantly improved functional recovery (p < 0.0001, repeated measures analysis of variance), and increased neurogenesis in the hippocampus and subventricular zone of the ipsilateral hemisphere (p = 0.0094 and p = 0.032, t‐test). Notably, we observed a significant increase in myelin (p = 0.0295, t‐test), platelet‐derived growth factor receptor α‐positive oligodendrocyte precursor cells (p = 0.0356, t‐test) and myelinating adenomatous polyposis coli‐positive cells within the ipsilateral internal capsule of anti‐LINGO‐1‐treated mice (p = 0.0021, t‐test). In conclusion, we identified anti‐LINGO‐1 as the first neuroregenerative treatment that counteracts poststroke demyelination of corticospinal tract neurons, presumably by increased proliferation of myelin precursor cells, and thereby improves functional recovery. Most importantly, our study presents myelin loss as a novel therapeutic target following stroke.
Exploring cellular diversity in lung adenocarcinoma epithelium: Advancing prognostic methods and immunotherapeutic strategies
Authors: Zhang Lianmin , Cui Yanan , Mei Jie , Zhang Zhenfa , Zhang Pengpeng 
Published: July 2024

AbstractImmunotherapy has brought significant advancements in the treatment of lung adenocarcinoma (LUAD), but identifying suitable candidates remains challenging. In this study, we investigated tumour cell heterogeneity using extensive single‐cell data and explored the impact of different tumour cell cluster abundances on immunotherapy in the POPLAR and OAK immunotherapy cohorts. Notably, we found a significant correlation between CKS1B+ tumour cell abundance and treatment response, as well as stemness potential. Leveraging marker genes from the CKS1B+ tumour cell cluster, we employed machine learning algorithms to establish a prognostic and immunotherapeutic signature (PIS) for LUAD. In multiple cohorts, PIS outperformed 144 previously published signatures in predicting LUAD prognosis. Importantly, PIS reliably predicted genomic alterations, chemotherapy sensitivity and immunotherapy responses. Immunohistochemistry validated lower expression of immune markers in the low‐PIS group, while in vitro experiments underscored the role of the key gene PSMB7 in LUAD progression. In conclusion, PIS represents a novel biomarker facilitating the selection of suitable LUAD patients for immunotherapy, ultimately improving prognosis and guiding clinical decisions.
Client and family experiences with telehealth‐delivered early psychosis services
Authors: Florence Ana Carolina , Stefančić Ana , Sheitman Adrienne , Fidaleo Kaleigh , Bello Iruma , Dixon Lisa , Drake Robert Eldon , Nossel Ilana , Cabassa Leopoldo J. , Montague Elaina , Pagdon Shannon , Lyn Jamaitreya , Patel Sapana R. 
Published: July 2024

AbstractObjectiveThe COVID‐19 pandemic prompted a significant shift to delivering early psychosis services using telehealth. Little is known about the experience of using telehealth in early psychosis services. This quality improvement qualitative project investigated the experiences of program participants and family members with telehealth services in OnTrackNY, an early intervention program for psychosis in New York State during the COVID‐19 pandemic.MethodsThe project team conducted individual interviews and focus groups. Data analyses used a matrix approach.ResultsNineteen OnTrackNY program participants and nine family members participated in five focus groups and nine individual interviews. Data were organized into five themes (a) accessibility: most individuals had a device and internet access and challenges were related to connectivity, such as image freezing and sound breaking; (b) convenience/flexibility: benefits included the reduced commute and costs; (c) levels of comfort/privacy with telehealth: program participants felt less judged and less anxiety leading up to in‐person appointments while also expressing privacy concerns; (d) sense of connectedness: in‐person social connections were deemed important and not replaceable by telehealth; and (e) suggestions: program participants expressed a preference for in‐person group activities and suggested hybrid options, highlighting the importance of in‐person visits to establish rapport at the beginning of treatment before transitioning to telehealth.ConclusionsTelehealth services were generally well accepted. Suggestions for future service delivery include offering a combination of telehealth and in‐person services based on program participants' preferences and prioritizing in‐person services during the early phase of treatment.
The Asymptomatic Proportion of SARS‐CoV‐2 Omicron Variant Infections in Households: A Systematic Review
Authors: Shi Nancy D. J. , Marcato Adrian J. , Spirkoska Violeta , Meagher Niamh , Villanueva‐Cabezas Juan‐Pablo , Price David J. 
Published: July 2024

ABSTRACTUnderstanding the clinical spectrum of SARS‐CoV‐2 infection, including the asymptomatic fraction, is important as asymptomatic individuals are still able to infect other individuals and contribute to ongoing transmission. The WHO Unity Household transmission investigation (HHTI) protocol provides a platform for the prospective and systematic collection of high‐quality clinical, epidemiological, serological and virological data from SARS‐CoV‐2 confirmed cases and their household contacts. These data can be used to understand key severity and transmissibility parameters—including the asymptomatic proportion—in relation to local epidemic context and help inform public health response. We aimed to estimate the asymptomatic proportion of SARS‐CoV‐2 Omicron variant infections in Unity‐aligned HHTIs. We conducted a systematic review and meta‐analysis in alignment with the PRISMA 2020 guidelines and registered our systematic review on PROSPERO (CRD42022378648). We searched EMBASE, Web of Science, MEDLINE and bioRxiv and medRxiv from 1 November 2021 to 22 August 2023. We identified 8368 records, of which 98 underwent full text review. We identified only three studies for data extraction, with substantial variation in study design and corresponding estimates of the asymptomatic proportion. As a result, we did not generate a pooled estimate or I2 metric. The limited number of quality studies that we identified highlights the need for improved preparedness and response capabilities to facilitate robust HHTI implementation, analysis and reporting, to better inform national, regional and global risk assessments and policymaking.
Current nursing and midwifery contribution to leading digital health policy and practice: An integrative review
Authors: Janes Gillian , Chesterton Lorna , Heaslip Vanessa , Reid Joanne , Lüdemann Bente , Gentil João , Oxholm Rolf‐André , Hamilton Clayton , Phillips Natasha , Shannon Michael 
Published: July 2024

AbstractAimTo review the current nursing and midwifery contribution to leading digital health (DH) policy and practice and what facilitates and/or challenges this.DesignIntegrative literature review.MethodsPre‐defined inclusion criteria were used. Study selection and quality assessment using the appropriate critical appraisal tools were undertaken by two authors, followed by narrative synthesis.Data SourcesSix databases and hand searching for papers published from 2012 to February 2024.FindingsFour themes were identified from 24 included papers. These are discussed according to the World Health Organization's Global Strategic Directions for Nursing and Midwifery and indicate nurses/midwives are leading DH policy and practice, but this is not widespread or systematically enabled.ConclusionNurses and midwives are ideally placed to help improve health outcomes through digital healthcare transformation, but their policy leadership potential is underused.Implications for the profession and/or patient careNurses/midwives' DH leadership must be optimized to realize maximum benefit from digital transformation. A robust infrastructure enabling nursing/midwifery DH policy leadership is urgently needed.ImpactThis study addresses the lack of nursing/midwifery voice in international DH policy leadership. It offers nurses/midwives and health policymakers internationally opportunity to: drive better understanding of nursing/midwifery leadership in a DH policy context; enhance population outcomes by optimizing their contribution; Develop a robust infrastructure to enable this.Reporting MethodReporting adheres to the EQUATOR network, Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) guidelines.Patient or Public ContributionNo patient or public contribution.
Financial Absorption of Cohesion Policy Funds: How Do Programmes and Territorial Characteristics Influence the Pace of Spending?
Authors: Santos Anabela M. , Conte Andrea , Molica Francesco 
Published: July 2024

AbstractUsing data from the execution of 2014–2020 cohesion policy, this article presents a novel indicator to measure how fast European territories were able to spend their allocated budget and then explores the drivers of such financial performance. This analysis aims to fill a gap in scientific literature as most existing studies tend to focus solely on the total absorption at the end of the period without looking at the average financial performance over time. The article also explores the influence on financial absorption of the governance model (nationally or regionally managed programmes) and the thematic structure of the funds, which has never been done before. The determinants of the speed of financial absorption are investigated through a Tobit model. Results show that both programme‐specific and territorial characteristics are relevant factors in explaining the varying levels of fund absorption. This suggests that increased flexibility in spending rules and the adoption of more tailored strategies could be instrumental in improving fund absorption.
What comes first: teeth or face? Recommendations for an interdisciplinary collaboration between facial esthetic surgery and dentistry
Authors: Ntovas Panagiotis , Grybauskas Simonas , Beiglboeck Fabian M , Kalash Ziad , Aida Seyidaliyeva , Att Wael 
Published: July 2024

AbstractObjectiveThe aim of the present study was to provide recommendations in order to facilitate communication between dental professionals and surgeons who are collaborating in the field of dentofacial esthetics.Clinical ConsiderationsSmile esthetics are beyond the scope, both of the surgeons who are collaborating with facial esthetics and of the dentists, as a wide range of treatment options from both sides is available. It can be difficult for the surgeon or the dentist that first comes in contact with the patient to conduct an individualized global treatment plan, in order to find out how the various phases of the treatment can be sequenced, as a workflow for an efficient interaction between facial surgery and dentistry still does not exist in the scientific literature.ConclusionsFacial cosmetic procedures and dental treatment have to be planned as individual elements of the whole dentofacial esthetic rehabilitation. The treatment has to be initiated with the design of the smile and the intraoral mock‐up, followed by the required surgical interventions, and to be finished with the delivery of the definitive dental restoration.Clinical SignificanceDentofacial esthetics require comprehensive communication between surgeons and dentists. Following the proposed recommendations, an individualized interdisciplinary treatment plan can be conducted, defining the role of each specialty.
Patient‐Provider Trust as a Key Component of Prenatal Screening for Adverse Childhood Experiences (ACES): A Concept Analysis
Authors: Gilliland Paige D. , Phipps Jennifer E. , Derret Breän , D'Souza Indira , Ha Stephanie , Patil Shwetha , Simmons Leigh Ann 
Published: July 2024

IntroductionThe concept of patient‐provider trust in prenatal adverse childhood experiences (ACEs) screening remains unexplored. This concept analysis illuminates the role of trust in prenatal ACE screening to improve patient‐provider relationships, increase patient uptake of ACE screening, and ensure that ACE screening is implemented in a strengths‐based, trauma‐informed way.MethodsA concept analysis was conducted using the Rodgers’ evolutionary method to define the antecedents, attributes, and consequences of this construct. The databases searched were PubMed, PsychInfo, and Scopus between 2010 and 2021. A total of 389 articles were retrieved using the search terms prenatal, adverse childhood experiences screening, adverse childhood experiences, and adverse childhood experiences questionnaire. Included articles for detailed review contained prenatal screening, trauma screening (ACE or other), trust or building trust between patient and health care provider, patient engagement, and shared decision making. Excluded articles were those not in the context of prenatal care and that were exclusively about screening with no discussion about the patient‐provider relationship or patient perspectives. A total of 32 articles were reviewed for this concept analysis.ResultsWe define trust in prenatal ACE screening as a network of evidence‐based attributes that include the timing of the screening, patient familiarity with the health care provider, cultural competence, demystifying trauma, open dialogue between the patient and health care provider, and patient comfort and respect.DiscussionThis concept analysis elucidates the importance of ACE screening and provides suggestions for establishing trust in the context of prenatal ACE screening. Results give insight and general guidance for health care providers looking to implement ACE screening in a trauma‐informed way. Further research is needed to evaluate pregnant patients' attitudes toward ACE screening and how a health care provider's trauma history might influence their care. More inquiry is needed to understand the racial, ethnic, and cultural barriers to ACE screening.