bluuebunny/crossref_metadata_2025_split huggingface dataset:
AN ASSESSMENT OF HUMAN PAPILLOMAVIRUS (HPV) VACCINE SERIES COMPLETION AND ON-TIME DOSING IN ONTARIO'S GRADE 8 HPV VACCINATION PROGRAM
Authors: Lim W Ting , Sears Kim , Smith Leah M , Liu Guoyuan , Lévesque Linda E 
Published: September 2013

IntroductionProper administration of the human papillomavirus (HPV) vaccine (three doses at 0, 2, and 6 months) will likely influence the vaccine's effectiveness and the impact of provincial vaccination programs on adolescent health.ObjectivesTo assess HPV vaccine series completion and on-time dosing in Canada's largest publicly funded, school-based vaccination program.MethodsUsing Ontario's administrative health and immunization databases, we identified a population-based cohort of all girls eligible for Ontario's Grade 8 HPV vaccination program in the 2007/08-2009/10 program years who initiated the three-dose vaccination series. Vaccine exposure was ascertained for two relevant time windows: Grade 8 and Grades 8–9. To assess series completion, we determined the number of doses each girl received and calculated the percentage that received all three. To assess on-time dosing, the number of days between doses (1–2, 2–3, 1–3) was calculated and categorized (e.g., too short, on schedule, too long) based on the manufacturer's recommendations. Analyses were also stratified by program year.ResultsBased on the data available at the time of analysis (i.e., from 21 of Ontario's 36 health regions), we identified a cohort of 55,798 girls who initiated the vaccination series. Series completion in the Grade 8 window was high (81.8%) and increased approximately 6% in Grade 9. Series completion was similar across the three program years. 70.8%, 98.5%, and 86.1% of girls were classified as ‘on schedule’ for dosing intervals 1–2, 2–3, and 1–3, respectively; 70.0% of girls received all three doses in perfect accordance with dosing recommendations. Stratification by program year revealed that on-time dosing was high in the first two years of the program (85.6% and 80.6%), but dropped to 42.1% in the 2009/10 program year when H1N1 vaccination programs were prioritized.ConclusionsPublicly funded, school-based HPV immunization programs overcome financial and accessibility barriers to healthcare, creating an ideal setting in which vaccine use be optimized. Indeed, our results indicate this approach to program delivery is enabling the vast majority of girls who initiate the vaccination series to successfully complete it as recommended.
DEVELOPMENTAL TRAJECTORIES OF BODY MASS INDEX THROUGHOUT ADULTHOOD: EVIDENCE FROM THE NATIONAL POPULATION HEALTH SURVEY
Authors: Wang Meng , Yi Yanqing 
Published: September 2013

BackgroundThere is little research that uses group-based trajectory modeling to capture adult body mass index (BMI) trajectories for the Canadian population.ObjectivesThe aims of this study are 1) to identify and determine the number and features of mutually exclusive body mass trajectory groups throughout adulthood; 2) to examine the association between covariates and each BMI trajectory group; 3) to assess whether health consequences vary within different trajectory groups.MethodsThis study will apply group-based trajectory modeling to map adult body mass trajectories with an age axis spanning 18 to 64 years, based on the longitudinal data from Statistics Canada's National Population Health Survey 1994 (n=17276). Group-based trajectory modeling is a powerful semi-parametric statistical approach that captures information about inter-individual differences within a large population. Risk factors (time-instable covariates) including gender and age cohort, and time-varying covariates such as diet, daily activities, education level, income, lifestyle (sleep, smoking, and alcohol), stress, and mental health are identified and evaluated for group membership. To confirm that distinct trajectory groups are linked to different health consequences, Rao-Scott chi-square test and analysis of variance will be applied to handle categorical and continuous health outcome variables. The health outcomes include hypertension, diabetes, heart disease, stroke, asthma, arthritis, and back problems. Lastly, this study will compare group-based trajectory modeling to a standard statistical methodology (multilevel modeling) when modeling longitudinal data, and discuss possible benefits.
THE EFFECT OF TELEPHONE SUPPORT INTERVENTIONS ON CORONARY ARTERY DISEASE (CAD) PATIENT OUTCOMES DURING CARDIAC REHABILITATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Kotb Ahmed , Wells George A. , Hsieh Shu-Ching 
Published: September 2013

BackgroundCardiac rehabilitation is offered to individuals after cardiac events to aid recovery and reduce the likelihood of further cardiac illness. However, patient participation remains suboptimal and the provision of high quality care to an expanding population of patients with chronic heart conditions is becoming increasingly difficult. As a result, the feasibility and effectiveness of using telehealth interventions to deliver care have recently been considered.ObjectivesTo determine the effect of telephone support interventions compared with standard post-discharge care on coronary artery disease patient outcomes.MethodsWe searched The Cochrane Library, MEDLINE, EMBASE, and CINAHL. Reference lists of included studies were also checked. No language restrictions were applied. Selection criteria: We included randomized controlled trials that directly compared telephone interventions with standard post-discharge care in adults following a myocardial infarction, angina or a revascularization procedure.Data collection and analysisStudies were selected independently by two reviewers. Data were extracted by a single reviewer and checked by a second one. Where appropriate, outcome data were pooled and analyzed using a random effects model. For dichotomous variables, odds ratios (OR) and 95% confidence intervals (CI) were derived for each outcome. For continuous variables, standardized mean differences (SMD) and 95% CI were calculated for each outcome.ResultsThirty-two studies met the inclusion criteria. No difference was observed in mortality between the telephone group and the group receiving standard care (OR 1.02 (0.69, 1.62)). The intervention was however significantly associated with fewer hospitalizations than the comparison group (OR 0.62 (0.40, 0.97)). Significantly more participants in the telephone group stopped smoking (OR 1.40 (1.08, 1.82)); had lower LDL levels (SMD −0.19 (−0.39, −0.00)); lower SBP (SMD −0.22 (−0.36, −0.07)); and higher physical composite scores for quality of life (SMD 0.15 (0.01, 0.30)). However, no significant differences were observed for medication adherence (OR 0.78 (0.78, 1.28)); and the mental composite score for quality of life (SMD −0.00 (−0.19, 0.18)).ConclusionsRegular telephone support interventions may help increase the uptake of secondary prevention and reduce further hospitalization.
IMPROVEMENT OF GLYCEMIC CONTROL IN PREDIABETIC AND TYPE 2 DIABETIC PATIENTS UNDERGOING LAPAROSCOPIC SLEEVE GASTRECTOMY (LSG) IN NEWFOUNDLAND AND LABRADOR
Authors: Lester Kendra , Twells Laurie , Gregory Deborah , Kovacs Christopher S. , Gamble J.M. 
Published: September 2013

IntroductionNewfoundland and Labrador (NL) has the highest prevalence of diabetes in the country. In 2011, 11.1% of the population were identified as diabetic. LSG is a minimally invasive and irreversible procedure in which 80% of the stomach is removed, leaving a much smaller stomach or “sleeve”. It is a promising treatment option for obesity, and recent studies demonstrate that LSG may be effective in improving/resolving T2DM in obese patients.ObjectivesThis study is evaluating LSG and its effectiveness in the improvement of glycemic control in prediabetes or type 2 diabetes mellitus (T2DM).MethodsAll patients (n=66) undergoing LSG in NL since May 2011 are followed prospectively. Patients are classified as having prediabetes (HbA1c: 5.7–6.4% or FPG: 6.1–6.9 mmol/L) or T2DM (HbA1c>6.5% or FPG≥7.0 mmol/L, self-reported, or antidiabetic medication use) at baseline. Glycemic control is evaluated at 3, 6, and 12 months. The primary outcome is the proportion of patients experiencing improved glycemic control.ResultsAt baseline, 16 (24.2%) patients have prediabetes (average HbA1c 5.8% (SD 0.3), FPG 5.6 mmol/L (SD 0.7)) and 31 (47.0%) have T2DM (average HbA1c 7.6% (SD 1.4), FPG 8.1 mmol/L (SD 2.5)). Interim analysis within 6 months post-surgery: of the 11 prediabetic patients who've completed follow-up, 8 (72.7%) have HbA1c<5.7% (p=0.004) and 11 (100%) FPG<6.1 mmol/L; of T2DM patients who've completed follow-up, 12 of 19 (63.2%) have HbA1c<6.5% (p<0.001) and 14 of 17 (82.4%) have FPG<7.0 mmol/L (p=0.003). Prediabetes and T2DM groups show significant improvements in HbA1c (-0.6% and -1.5% respectively) and FPG (-1.0 mmol/L and -2.0 mmol/L respectively), p<0.001 for all. 9 of 21 T2DM patients (42.9%) who completed follow-up are no longer taking antidiabetic medications.ConclusionsInterim analysis indicates better glucose control is achieved within 6 months following LSG.
TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase
Authors: Wang Xiaoping , Saso Hitomi , Iwamoto Takayuki , Xia Weiya , Gong Yun , Pusztai Lajos , Woodward Wendy A. , Reuben James M. , Warner Steven L. , Bearss David J. , Hortobagyi Gabriel N. , Hung Mien-Chie , Ueno Naoto T. 
Published: September 2013

Abstract
Inflammatory breast cancer (IBC) is the most lethal form of breast cancer, but the basis for its aggressive properties are not fully understood. In this study, we report that high tumoral expression of TIG1 (RARRES1), a functionally undefined membrane protein, confers shorter survival in patients with IBC. TIG1 depletion decreased IBC cell proliferation, migration, and invasion in vitro and inhibited tumor growth of IBC cells in vivo. We identified the receptor tyrosine kinase, Axl, as a TIG1-binding protein. TIG1 interaction stablilized Axl by inhibiting its proteasome-dependent degradation. TIG1-depleted IBC cells exhibited reduced Axl expression, inactivation of NF-κB, and downregulation of matrix metalloproteinase-9, indicating that TIG1 regulates invasion of IBC cells by supporting the Axl signaling pathway in IBC cells. Consistent with these results, treatment of IBC cells with the Axl inhibitor SGI-7079 decreased their malignant properties in vitro. Finally, TIG1 expression correlated positively with Axl expression in primary human IBC specimens. Our findings establish that TIG1 positively modifies the malignant properties of IBC by supporting Axl function, advancing understanding of its development and rationalizing TIG1 and Axl as promising therapeutic targets in IBC treatment. Cancer Res; 73(21); 6516–25. ©2013 AACR.
Size Matters! Impact of Age, Sex, Height, and Weight on the Normal Heart Size
Authors: Pfaffenberger Stefan , Bartko Philipp , Graf Alexandra , Pernicka Elisabeth , Babayev Jamil , Lolic Emina , Bonderman Diana , Baumgartner Helmut , Maurer Gerald , Mascherbauer Julia 
Published: September 2013

Background—
Therapeutic decisions in cardiology are determined frequently by cardiac chamber size. To decide whether cardiac dimensions are still in the normal range, reliable reference values are needed. However, published reference values mostly refer to historical cohorts using motion-mode measurements and have not been adjusted for sex or age. The impact of body size was only vaguely addressed. The importance of such adjustments is illustrated by studies, which show that smaller individuals and women are at risk of delayed treatment and impaired outcome when currently used reference values are applied. The aim of the present study was to assess the impact of body size, sex, and age on the normal heart size.

Methods and Results—
We prospectively studied 622 individuals (52.7% women; 17–91 years; 143–200 cm; 32–240 kg) without cardiac disease by standard transthoracic echocardiography. Multivariable linear regression analyses of the impact of sex, age, height, and weight on cardiac chamber size were performed. By multivariable regression analysis (n=500), all 4 variables independently influenced cardiac chamber size. The validity of cardiac dimensions predicted by the regression model was tested prospectively in a validation cohort (n=122). A calculator is proposed that estimates cardiac dimensions on the basis of the regression analysis.

Conclusions—
Sex, height, weight, and age significantly affect the normal heart size. These parameters need to be considered when cutoff values indicating the need for treatment or even surgery are established.
Effect of the Proprotein Convertase Subtilisin/Kexin 9 Monoclonal Antibody, AMG 145, in Homozygous Familial Hypercholesterolemia
Authors: Stein Evan A. , Honarpour Narimon , Wasserman Scott M. , Xu Feng , Scott Rob , Raal Frederick J. 
Published: September 2013

Background—
Homozygous familial hypercholesterolemia is a rare, serious disorder with a substantial reduction in low-density lipoprotein (LDL) receptor function, severely elevated LDL cholesterol, cardiovascular disease, and often death in childhood. Response to conventional drug therapies is modest. Monoclonal antibodies to proprotein convertase subtilisin/kexin 9 (PCSK9) reduce LDL cholesterol in heterozygous familial hypercholesterolemia. The effect in homozygous familial hypercholesterolemia is unknown and uncertain. We evaluated the efficacy and safety of AMG 145 in an open-label, single-arm, multicenter, dose-scheduling pilot study in patients with homozygous familial hypercholesterolemia.

Methods and Results—

Eight patients with LDL receptor–negative or –defective homozygous familial hypercholesterolemia on stable drug therapy were treated with subcutaneous 420 mg AMG 145 every 4 weeks for ≥12 weeks, followed by 420 mg AMG 145 every 2 weeks for an additional 12 weeks. All patients completed both treatment periods. Mean change from baseline in LDL cholesterol at week 12 was −16.5% (range, 5.2% to −43.6%;
P
=0.0781) and −13.9% (range, 39.9% to −43.3%;
P
=0.1484) with 4- and 2-week dosing, respectively. No reduction was seen in the 2 receptor-negative patients. Over the treatment periods, mean±SD LDL cholesterol reductions in the 6 LDL receptor–defective patients were 19.3±16% and 26.3±20% with 4- and 2-week dosing, respectively (
P
=0.0313 for both values), ranging from 4% to 48% with 2-week dosing. No serious side effects were reported.

Conclusion—
This study demonstrates significant and dose-related LDL cholesterol lowering with a PCSK9 monoclonal antibody in homozygous familial hypercholesterolemia patients with defective LDL receptor activity but no reduction in those who were receptor negative.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifiers: NCT01588496 and NCT01624142.
A dual-task home-based rehabilitation programme for improving balance control in patients with acquired brain injury: a single-blind, randomized controlled pilot study
Authors: Peirone Eliana , Goria Paolo Filiberto , Anselmino Arianna 
Published: September 2013

Objective: To evaluate the safety, feasibility and effectiveness of a dual-task home-based rehabilitation programme on balance impairments among adult patients with acquired brain injury. Design: Single-blind, randomized controlled pilot study. Setting: Single rehabilitation centre. Subjects: Sixteen participants between 12 and 18 months post-acquired brain injury with balance impairments and a score <10 seconds on the One-Leg Stance Test (eyes open). Intervention: All participants received 50-minutes individualised traditional physiotherapy sessions three times a week for seven weeks. In addition, the intervention group ( N = 8) performed an individualised dual-task home-based programme six days a week for seven weeks. Main outcome measures: The primary outcome measure was the Balance Evaluation System Test; secondary measures were the Activities-specific Balance Confidence Scale and Goal Attainment Scaling. Results: At the end of the pilot study, the intervention group showed significantly greater improvement in Balance Evaluation System Test scores (17.87, SD 6.05) vs. the control group (5.5, SD 3.53; P = 0.008, r = 0.63). There was no significant difference in improvement in Activities-specific Balance Confidence Scale scores between the intervention group (25.25, SD 25.51) and the control group (7.00, SD 14.73; P = 0.11, r = 0.63). There was no significant improvement in Goal Attainment Scaling scores in the intervention (19.37, SD 9.03) vs. the control group (16.28, SD 6.58; P = 0.093, r = 0.63). Conclusions: This pilot study shows the safety, feasibility and short-term benefit of a dual-task home-based rehabilitation programme to improve balance control in patients with acquired brain injury. A sample size of 26 participants is required for a definitive study.
Biphasic calcium phosphate loading on polycaprolactone/poly(lacto-co-glycolic acid) membranes for improved tensile strength, in vitro biocompatibility, and in vivo tissue regeneration
Authors: Franco Rose Ann , Sadiasa Alexander , Seo Hyung Seok , Lee Byong-Taek 
Published: September 2013

Electrospun polycaprolactone and poly(lacto- co-glycolide) membranes were loaded with biphasic calcium phosphate powder to facilitate osteoconductivity. Different concentrations of biphasic calcium phosphate powder were added to the polymer solution, and successful loading was confirmed by X-ray diffraction analysis, transmission electron microscope, and scanning electron microscope with energy-dispersive spectroscopy visualization. The effect of the added biphasic calcium phosphate on the polymer membrane was investigated in terms of the material’s tensile strength and strain, in vitro cytocompatibility, and in vivo tissue regeneration. It was observed that the tensile strength of the membranes increased with the addition of the biphasic calcium phosphate powder. Immersion in simulated body fluid solution for seven days leads to the formation of apatite-like deposits in the fibers, which further improved the mechanical stability. Moreover, proliferation and adhesion of osteoblast-like cells were more apparent upon the addition of the biphasic calcium phosphate powder as seen with the increasing cell density from (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and micrographs from scanning electron microscope and confocal microscopy. Sample membranes were also implanted to investigate the membrane’s ability to regenerate bone in a rat calvarium. Histological staining and micro-CT histomorphometric analyses showed neo-bone formation in the implanted rat skull.
A redundant epistatic interaction between IRF5 and STAT4 of the type I interferon pathway in susceptibility to lupus and rheumatoid arthritis
Authors: Kim K , Cho S-K , Han T-U , Kim J-H , Kang S-J , Kang C , Bae S-C 
Published: September 2013

Objective K. K. and S.-K. C. are co-first authors, and C. K. and S.-C. B. are co-senior authors. Two transcription factors in the type I interferon pathway, IRF5 and STAT4, have been genetically associated with susceptibility to both systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This study aimed to determine whether these two genes interact with each other to affect the disease susceptibilities. Methods The genetic interactions between IRF5 and STAT4 polymorphisms in SLE and RA susceptibility were examined using the epistasis options in PLINK software. This study analyzes the genetic data from 2558 unrelated Korean participants including 589 SLE patients, 987 RA patients, and 982 controls. Results All 12 polymorphisms were individually associated with SLE susceptibility ( p = 2.49 × 10−8 to 0.00360). Among the three SLE-associated polymorphisms of IRF5, rs77571059, alternatively called CGGGG(3–4) indel, exhibited the lowest p value (4.60 × 10−5) and accounted for the observed associations of the other two single-nucleotide polymorphisms (SNPs). Among the nine SLE-associated SNPs of STAT4, rs16833215 exhibited the lowest p value (2.49 × 10−8) and accounted for all the other associations. These two polymorphisms, rs77571059 of IRF5 and rs16833215 of STAT4, interacted with each other for SLE susceptibility in a redundant manner (ORinteraction = 0.77, Pepistasis = 0.040). Furthermore, these two polymorphisms, which had been individually associated with RA susceptibility, also interacted for RA susceptibility in the same manner (ORinteraction = 0.75, Pepistasis = 0.014). Conclusions A redundant interaction between IRF5 and STAT4 polymorphisms was found in susceptibility to the type I interferon pathway-associated rheumatic autoimmune diseases, SLE and RA, calling for further studies on confirmation of these findings.
Workplace stress in community pharmacies in England: associations with individual, organizational and job characteristics
Authors: Jacobs Sally , Hassell Karen , Ashcroft Darren , Johnson Sheena , O’Connor Elinor 
Published: September 2013

Objectives To describe the levels of workplace stress that community pharmacists perceive and to examine associations with individual, organizational and job characteristics. Methods A cross-sectional mailed survey of 2000 randomly selected community pharmacists practising in England incorporating a validated organizational stress screening tool (ASSET). Results Response rate was 48%. Community pharmacists reported significantly higher levels of stress than other health care workers for seven out of eight work-related stressors. Regression analyses demonstrated significant associations between a number of individual, organizational and job characteristics and stress. Long working days, being a pharmacy manager and working for large multiples were associated with higher reported levels of stress across a number of work-related stressors including work overload, control and the job itself. However, self-reported measures of workload (such as dispensing volume) were not associated with higher stress levels. Conclusions The growth in corporate ownership of community pharmacies, which is associated with more stressful working environments, together with current economic pressures could have consequences not only for the future well-being of pharmacists but also for patient safety.
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
Authors: Willems Lise , Jacque Nathalie , Jacquel Arnaud , Neveux Nathalie , Trovati Maciel Thiago , Lambert Mireille , Schmitt Alain , Poulain Laury , Green Alexa S. , Uzunov Madalina , Kosmider Olivier , Radford-Weiss Isabelle , Moura Ivan Cruz , Auberger Patrick , Ifrah Norbert , Bardet Valérie , Chapuis Nicolas , Lacombe Catherine , Mayeux Patrick , Tamburini Jérôme , Bouscary Didier 
Published: September 2013

Key PointsGlutamine removal and knockdown of the glutamine transporter SLC1A5 have antileukemic activity in AML. The glutaminase activity of l-asparaginase inhibits mTORC1 and protein synthesis and induces a strong autophagy in AML.
Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
Authors: Wang Michael , Martin Tom , Bensinger William , Alsina Melissa , Siegel David S. , Kavalerchik Edward , Huang Mei , Orlowski Robert Z. , Niesvizky Ruben 
Published: September 2013

Key Points
Presented are results from the phase 2 dose-expansion study of the combination of carfilzomib, lenalidomide, and dexamethasone (CRd). CRd was well tolerated with robust, rapid, and durable responses.