bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is overweight at 12 months associated with differences in eating behaviour or dietary intake among children selected for inappropriate bottle use?
Authors: Bonuck Karen , Avraham Sivan Ben , Hearst Mary , Kahn Richard , Hyden Christel 
Published: April 2013

AbstractBottle feeding beyond the recommended weaning age of 12 months is a risk factor for childhood obesity. This paper describes a sample of toddlers at high risk for obesity: prolonged bottle users from a low‐income multi‐ethnic community. We report here baseline mealtime and feeding behaviour, 24 h dietary recall and bottle intake data for Feeding Young Children Study (FYCS) participants, by overweight (≥85% weight‐for‐length) status. FYCS enrolled 12–13‐month‐olds from urban nutrition programmes for low‐income families in the United States who were consuming ≥2 bottles per day. Our sample was predominately Hispanic (62%), 44% of mothers were born outside of the United States and 48% were male. Overall, 35% were overweight. Overweight status was not associated with mealtime/feeding behaviours, bottle use or dietary intake. Most (90%) children ate enough, were easily satisfied and did not exhibit negative (e.g. crying, screaming) mealtime behaviours, per parent report. The sample's median consumption of 4 bottles per day accounted for 50% of their total calories; each bottle averaged 7 ounces and contained 120 calories. Mean daily energy intake, 1098.3 kcal day−1 (standard deviation = 346.1), did not differ by weight status, nor did intake of fat, saturated fat, protein or carbohydrates. Whole milk intake, primarily consumed via bottles, did not differ by weight status. Thus, overweight 12–13‐month‐olds in FYCS were remarkably similar to their non‐overweight peers in terms of several obesity risk factors. Findings lend support to the set‐point theory and prior work finding that weight and intake patterns in the first year of life alter subsequent obesity risk.
Early prenatal food supplementation ameliorates the negative association of maternal stress with birth size in a randomised trial
Authors: Frith Amy L. , Naved Ruchira T. , Persson Lars Ake , Frongillo Edward A. 
Published: April 2013

AbstractLow birthweight increases the risk of infant mortality, morbidity and poor development. Maternal nutrition and stress influence birth size, but their combined effect is not known. We hypothesised that an early‐invitation time to start a prenatal food supplementation programme could reduce the negative influence of prenatal maternal stress on birth size, and that effect would differ by infant sex. A cohort of 1041 pregnant women, who had delivered an infant, June 2003–March 2004, was sampled from among 3267 in the randomised controlled trial, Maternal Infant Nutritional Interventions Matlab, conducted in Matlab, Bangladesh. At 8 weeks gestation, women were randomly assigned an invitation to start food supplements (2.5 MJ d−1; 6 days a week) either early (∼9 weeks gestation; early‐invitation group) or at usual start time for the governmental programme (∼20 weeks gestation; usual‐invitation group). Morning concentration of cortisol was measured from one saliva sample/woman at 28–32 weeks gestation to assess stress. Birth‐size measurements for 90% of infants were collected within 4 days of birth. In a general linear model, there was an interaction between invitation time to start the food supplementation programme and cortisol with birthweight, length and head circumference of male infants, but not female infants. Among the usual‐invitation group only, male infants whose mothers had higher prenatal cortisol weighed less than those whose mothers had lower prenatal cortisol. Prenatal food supplementation programmes that begin first trimester may support greater birth size of male infants despite high maternal stress where low birthweight is a public health concern.
Validation of Self‐Reported Colorectal Cancer Screening Behaviors Among Appalachian Residents
Authors: Reiter Paul L. , Katz Mira L. , Oliveri Jill M. , Young Gregory S. , Llanos Adana A. , Paskett Electra D. 
Published: April 2013

AbstractObjectivesWe determined the validity of self‐reported colorectal cancer (CRC) screening data provided by Appalachian Ohio residents and identified correlates of providing accurate data.Design and SampleWe conducted cross‐sectional telephone interviews between September 2009 and April 2010. Our study included Appalachian Ohio residents (n = 721) ages 51–75 years.MeasuresWe compared self‐reported CRC screening data to medical records to determine validity. Multivariable logistic regression was used to identify correlates of providing accurate self‐reported screening data.ResultsAbout 68% of participants self‐reported having any CRC screening test within recommended guidelines, whereas medical records indicated that only 49% were within guidelines (concordance = 0.76). Concordance was higher for flexible sigmoidoscopy and fecal occult blood test compared with colonoscopy, although sensitivity and positive predictive value were much higher for colonoscopy. Participants overreported CRC screening behaviors for all tests. Participants who had a regular checkup in the last 2 years (OR = 2.78, 95% CI: 1.15–6.73), or who self‐rated their health as good or better (OR = 1.88, 95% CI: 1.12–3.16) were more likely to provide accurate screening data.ConclusionsMany participants failed to provide accurate CRC screening data, and validity varied greatly across individual CRC screening tests. Future CRC screening studies among Appalachian residents should use medical records, if possible, to determine screening histories.
Sketching the Contours of the Scholarship of Teaching and Learning in Theology and Religion
Authors: Killen Patricia O'Connell , Gallagher Eugene V. 
Published: April 2013

AbstractThis article argues that there is an identifiable scholarship of teaching and learning in theology and religion that, though varied in its entry points and forms, exhibits standards of excellence recognizable in other forms of scholarship. Engaging in this scholarship enhances a professor's possession of practice and often reveals insights into student learning and the contours of a field that can advance both educational and disciplinary projects. Through conversation with a form of the scholarship of teaching and learning that emerged most clearly in work associated with the Carnegie Foundation for the Advancement of Teaching, we describe starting points and generative assumptions that have been employed in the discourse of the scholarship of teaching and learning in theology and religion as they have emerged in submissions to Teaching Theology and Religion over the past decade and a half and point to its benefits. See responses to this essay by Charles R. Foster, Stephen Brookfield, and Pat Hutchings published in this issue of the journal. Responses by Reid B. Locklin, Joanne Maguire Robinson, and Nadine S. Pence appear in next issue issue, 16:3 (2013).
Bridging the “Great Divide” in Undergraduate Religion: An Experiment in Faculty/Student Collaboration
Authors: Lanci John R. 
Published: April 2013

AbstractUndergraduate students today often enroll in introductory religious studies or theology classes because they want the time and space to reflect on their personal spiritual questions. Such a motivation can clash with the faculty's desire to introduce students to rigorous academic study of their field. Barbara Walvoord has proposed four “voices” that students may develop that will assist both student and faculty to cross this “great divide.” This essay explores the ways in which a course based in engaged pedagogical theory and practice – in this case, problem‐based learning – can provide an effective space for students to “find their voices,” take control of their own learning, and fulfill both their own and their professor's expectations.
From Civic Engagement to Circles of Grace: Mid‐Range Reflection on Teaching for Global Citizenship
Authors: Corrie Elizabeth W. 
Published: April 2013

AbstractThe course “Empowering Youth for Global Citizenship” seeks to equip students to teach global citizenship by engaging them in practices of ascetic withdrawal from consumer habits and active engagement in the public sphere. These goals underlie the design of the assignments, but should have also shaped the relationship between the assignments themselves. This article addresses the issue of course design in the service of empowering students for engagement in the public sphere by reflecting upon the course assignments, with emphasis on a project that worked well, and the implications this has for its relationship to the other course assignments, including one that missed the mark. The exploration of this misalignment between the learning goals and actual outcomes of the different assignments brings to light the unique role of learning communities of accountability and acceptance in deepening the impact of assignments aimed at personal transformation, as well as the rich dynamic that can come from coordinating course assignments to bring “head, heart, and hands” together.
Whole-Genome Shotgun Assembly and Analysis of the Genome of Streptomyces mobaraensis DSM 40847, a Strain for Industrial Production of Microbial Transglutaminase
Authors: Yang Huilin , He Tiansheng , Wu Wenxia , Zhu Weitao , Lu Bai , Sun Wanju 
Published: April 2013

ABSTRACT

Here, we report the draft annotated genome sequence of
Streptomyces mobaraensis
strain DSM 40847, which is used in industry to produce microbial transglutaminase. The genome sequence will allow for the characterization of the molecular mechanisms underlying the beneficial properties of this organism.
Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast
Authors: Jang Se Min , Sim Jongmin , Han Hulin , Ahn Hye In , Kim Hyunsung , Yi Kijong , Jun Young Jin , Rehman Abdul , Chung Min Sung , Jang Kiseok , Paik Seung Sam 
Published: April 2013

AimsCell adhesion molecule 4 (CADM4) is a novel tumour suppressor involved in cell adhesion. Loss or decreased expression of CADM4 has been associated with the development and progression of some cancers. The purpose of this study was to investigate the clinicopathological significance of CADM4 expression in breast cancer.MethodsWe constructed tissue microarrays to evaluate the immunohistochemical expression of CADM4 in 256 cases of invasive ductal carcinoma (IDC) and 45 cases of ductal carcinoma in situ (DCIS).ResultsCADM4 was expressed in 37 (82.2%) DCIS cases, and in 173 (67.6%) IDC cases. CADM4 expression was higher in DCIS than in IDC (p=0.049). Loss or decrease of CADM4 expression was significantly correlated with higher histological grade (p=0.020), absence of oestrogen receptors (p<0.001), absence of progesterone receptors (p=0.024), and overexpression of c-erbB-2 (p=0.018). In univariable and multivariable Cox regression analyses of all 256 IDC cases, CADM4 expression was not significantly associated with overall and disease-free survival. However, it showed a significant positive association with longer disease-free survival in 187 stages I and II IDC cases (p=0.039, log-rank test).ConclusionsLoss or decrease of CADM4 expression seems to play an important role in breast cancer invasiveness, and it is associated with poorer biological parameters. CADM4 can be used as a novel marker predicting risk of recurrence and disease outcomes in stages I and II IDC.
Identification of Targetable FGFR Gene Fusions in Diverse Cancers
Authors: Wu Yi-Mi , Su Fengyun , Kalyana-Sundaram Shanker , Khazanov Nickolay , Ateeq Bushra , Cao Xuhong , Lonigro Robert J. , Vats Pankaj , Wang Rui , Lin Su-Fang , Cheng Ann-Joy , Kunju Lakshmi P. , Siddiqui Javed , Tomlins Scott A. , Wyngaard Peter , Sadis Seth , Roychowdhury Sameek , Hussain Maha H. , Feng Felix Y. , Zalupski Mark M. , Talpaz Moshe , Pienta Kenneth J. , Rhodes Daniel R. , Robinson Dan R. , Chinnaiyan Arul M. 
Published: April 2013

Abstract
Through a prospective clinical sequencing program for advanced cancers, four index cases were identified which harbor gene rearrangements of FGFR2, including patients with cholangiocarcinoma, breast cancer, and prostate cancer. After extending our assessment of FGFR rearrangements across multiple tumor cohorts, we identified additional FGFR fusions with intact kinase domains in lung squamous cell cancer, bladder cancer, thyroid cancer, oral cancer, glioblastoma, and head and neck squamous cell cancer. All FGFR fusion partners tested exhibit oligomerization capability, suggesting a shared mode of kinase activation. Overexpression of FGFR fusion proteins induced cell proliferation. Two bladder cancer cell lines that harbor FGFR3 fusion proteins exhibited enhanced susceptibility to pharmacologic inhibition in vitro and in vivo. Because of the combinatorial possibilities of FGFR family fusion to a variety of oligomerization partners, clinical sequencing efforts, which incorporate transcriptome analysis for gene fusions, are poised to identify rare, targetable FGFR fusions across diverse cancer types.
Significance: High-throughput sequencing technologies facilitate defining the mutational landscape of human cancers, which will lead to more precise treatment of patients with cancer. Here, through integrative sequencing efforts, we identified a variety of FGFR gene fusions in a spectrum of human cancers. FGFR fusions are active kinases. Cells harboring FGFR fusions showed enhanced sensitivity to the FGFR inhibitors PD173074 and pazopanib, suggesting that patients with cancer with FGFR fusions may benefit from targeted FGFR kinase inhibition. Cancer Discov; 3(6); 636–47. ©2013 AACR.
See related commentary by Sabnis and Bivona, p. 607
This article is highlighted in the In This Issue feature, p. 591
Loss of Function of Parathyroid Hormone Receptor 1 Induces Notch-Dependent Aortic Defects During Zebrafish Vascular Development
Authors: Gray Caroline , Bratt David , Lees Julie , daCosta Marc , Plant Karen , Watson Oliver J. , Solaymani-Kohal Sara , Tazzyman Simon , Serbanovic-Canic Jovana , Crossman David C. , Keavney Bernard D. , Haase Andrea , McMahon Kathryn , Gering Martin , Roehl Henry , Evans Paul C. , Chico Timothy J.A. 
Published: April 2013

Objective—
Coarctation of the aorta is rarely associated with known gene defects. Blomstrand chondrodysplasia, caused by mutations in the parathyroid hormone receptor 1 (PTHR1) is associated with coarctation of the aorta in some cases, although it is unclear whether PTHR1 deficiency causes coarctation of the aorta directly. The zebrafish allows the study of vascular development using approaches not possible in other models. We therefore examined the effect of loss of function of PTHR1 or its ligand parathyroid hormone-related peptide (PTHrP) on aortic formation in zebrafish.

Approach and Results—

Morpholino antisense oligonucleotide knockdown of either PTHR1 or PTHrP led to a localized occlusion of the mid-aorta in developing zebrafish. Confocal imaging of transgenic embryos showed that these defects were caused by loss of endothelium, rather than failure to lumenize. Using a Notch reporter transgenic ([
CSL:Venus
]
qmc61
), we found both PTHR1 and PTHrP knockdown-induced defective Notch signaling in the hypochord at the site of the aortic defect before onset of circulation, and the aortic occlusion was rescued by inducible Notch upregulation.

Conclusions—
Loss of function of either PTHR1 or PTHrP leads to a localized aortic defect that is Notch dependent. These findings may underlie the aortic defect seen in Blomstrand chondrodysplasia, and reveal a link between parathyroid hormone and Notch signaling during aortic development.
Characterization of Levels and Cellular Transfer of Circulating Lipoprotein-Bound MicroRNAs
Authors: Wagner Jasmin , Riwanto Meliana , Besler Christian , Knau Andrea , Fichtlscherer Stephan , Röxe Tino , Zeiher Andreas M. , Landmesser Ulf , Dimmeler Stefanie 
Published: April 2013

Objective—
MicroRNAs are important intracellular regulators of gene expression, but also circulate in the blood being protected by extracellular vesicles, proteins, or high-density lipoprotein (HDL). Here, we evaluate the regulation and potential function of HDL- and low-density lipoprotein–bound miRs isolated from healthy subjects and patients with coronary artery disease.

Approach and Results—
HDL-bound miRs with known effects in the cardiovascular system were analyzed in HDL isolated from healthy subjects (n=10), patients with stable coronary artery disease (n=10), and patients with an acute coronary syndrome (n=10). In HDL from healthy subjects, miR-223 was detected at concentrations >10 000 copies/µg HDL, and miR-126 and miR-92a at about 3000 copies/µg HDL. Concentrations of most miRs were substantially higher in HDL as compared with low-density lipoprotein. However, HDL-bound miR-223 contributed to only 8% of the total circulating miRs. The signatures of miRs varied only slightly in HDL derived from patients with coronary artery disease. We did not observe a significant uptake of HDL-bound miRs into endothelial cells, smooth muscle cells, or peripheral blood mononuclear cells. However, patient-derived HDL transiently reduced miR expression particularly when incubated with smooth muscle and peripheral blood mononuclear cells.

Conclusions—
Circulating miRs are detected in HDL and to a lesser extent in low-density lipoprotein, and the miR-signatures are only slightly altered in patients with coronary artery disease. Lipoprotein-bound miRs were not efficiently delivered to endothelial, smooth muscle, and peripheral blood mononuclear cells suggesting that the lipoprotein-associated pool of miRs is not regulating the function of the studied cells in vitro.
ABCA1 Mediates Unfolding of Apolipoprotein AI N Terminus on the Cell Surface Before Lipidation and Release of Nascent High-Density Lipoprotein
Authors: Wang Shuhui , Gulshan Kailash , Brubaker Gregory , Hazen Stanley L. , Smith Jonathan D. 
Published: April 2013

Objective—
To gain insight into the mechanism by which ABCA1 generates nascent high-density lipoprotein.

Approach and Results—
HEK293 cells were stably transfected with ABCA1 vectors, encoding wild type, and the W590S and C1477R Tangier disease mutation isoforms, along with the K939M ATP-binding domain mutant. Apolipoprotein AI (ApoAI) binding, plasma membrane remodeling, cholesterol efflux, apoAI cell surface unfolding, and apoAI cell surface lipidation were determined, the latter 2 measured using novel fluorescent apoAI indicators. The W590S isoform had decreased plasma membrane remodeling and lipid efflux activities, and the C1477R isoform had decreased apoAI binding, and lipid efflux activities, whereas the K939M isoform did not bind apoAI, remodel the membrane, or efflux cholesterol. However, all ABCA1 isoforms led to apoAI unfolding at the cell surface, which was higher for the isoforms that increased apoAI binding. ApoAI lipidation was not detected on ABCA1-expressing cells, only in the conditioned medium, consistent with rapid release of nascent high-density lipoprotein from ABCA1-expressing cells.

Conclusions—
We identified a third activity of ABCA1, the ability to unfold the N terminus of apoAI on the cell surface. Our results support a model in which unfolded apoAI on the cell surface is an intermediate in its lipidation and that, once apoAI is lipidated, it forms an unstable structure that is rapidly released from the cells to generate high-density lipoprotein.
MicroRNA-93 Controls Perfusion Recovery After Hindlimb Ischemia by Modulating Expression of Multiple Genes in the Cell Cycle Pathway
Authors: Hazarika Surovi , Farber Charles R. , Dokun Ayotunde O. , Pitsillides Achillieas N. , Wang Tao , Lye R. John , Annex Brian H. 
Published: April 2013

Background—
MicroRNAs are key regulators of gene expression in response to injury, but there is limited knowledge of their role in ischemia-induced angiogenesis, such as in peripheral arterial disease. Here, we used an unbiased strategy and took advantage of different phenotypic outcomes that follow surgically induced hindlimb ischemia between inbred mouse strains to identify key microRNAs involved in perfusion recovery from hindlimb ischemia.

Methods and Results—
From comparative microRNA profiling between inbred mouse strains that display profound differences in their extent of perfusion recovery after hindlimb ischemia, we found that the mouse strain with higher levels of microRNA-93 (miR-93) in hindlimb muscle before ischemia and the greater ability to upregulate miR-93 in response to ischemia had better perfusion recovery. In vitro, overexpression of miR-93 attenuated hypoxia-induced apoptosis in both endothelial and skeletal muscle cells and enhanced proliferation in both cell types. In addition, miR-93 overexpression enhanced endothelial cell tube formation. In vivo, miR-93 overexpression enhanced capillary density and perfusion recovery from hindlimb ischemia, and antagomirs to miR-93 attenuated perfusion recovery. Both in vitro and in vivo modulation of miR-93 resulted in alterations in the expression of >1 cell cycle pathway gene in 2 different cell types.

Conclusions—
Our data indicate that miR-93 enhances perfusion recovery from hindlimb ischemia by modulation of multiple genes that coordinate the functional pathways of cell proliferation and apoptosis. Thus, miR-93 is a strong potential target for pharmacological modulation to promote angiogenesis in ischemic tissue.
Social Movements, Left Governments, and the Limits of Water Sector Reform in Latin America’s Left Turn
Authors: Terhorst Philipp , Olivera Marcela , Dwinell Alexander 
Published: April 2013

Popular water movements were a crucial part of the rise of left social forces and governments in Latin America, and in Uruguay, Bolivia, and Ecuador, in particular, they set new agendas. An examination of the relation between social movements and left governments in the search for post-neoliberal pathways in the water sector reveals political experimentation with contradictory results. Structural dependencies and the failure to develop, through the politics of the left turn, state-society relations conducive to sector transformation limit the scope of maneuver for alternatives. A radical politics of mass mobilization has been indispensable in water reforms. Likewise, effective implementation of alternatives to neoliberalism requires, even at the risk of ongoing conflict, interaction between movements and governments that respects the autonomy of the people, reduces predominant capitalist dependencies, and transforms the state. Los movimientos populares por el agua constituyeron una parte crucial del auge de gobiernos y fuerzas sociales de izquierda en América Latina, y en Uruguay, Bolivia y Ecuador, en particular, fijaron nuevas agendas. Un examen de la relación entre movimientos sociales y gobiernos de izquierda en la búsqueda de caminos post-neoliberales en el sector del agua revela experimentación política con resultados contradictorios. Las dependencias estructurales e incapacidad de desarrollar, a través de las políticas del giro a la izquierda, relaciones estado-sociedad que conducían a transformaciones sectoriales limitan el campo de maniobra para alternativas. Una política radical de movilización masiva ha sido indispensable en las reformas del agua. Asimismo, una implementación efectiva de alternativas al neoliberalismo requiere interacción, aun a riesgo de conflicto continuo, entre movimientos y gobiernos que respeta la autonomía del pueblo, reduce dependencias capitalistas predominantes, y transforma el estado.