bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of preoperative embolization for intracranial meningiomas
Authors: Shah Ashish H. , Patel Neal , Raper Daniel M. S. , Bregy Amade , Ashour Ramsey , Elhammady Mohamed Samy , Aziz-Sultan Mohammad Ali , Morcos Jacques J. , Heros Roberto C. , Komotar Ricardo J. 
Published: April 2013

Object
As endovascular techniques have become more advanced, preoperative embolization has become an increasingly used intervention in the management of meningiomas. To date, however, no consensus has been reached on the use of this technique. To clarify the role of preoperative embolization in the management of meningiomas, the authors conducted a systematic review of case reports, case series, and prospective studies to increase the current understanding of the management options for these common lesions and complications associated with preoperative embolization.

Methods
A PubMed search was performed to include all relevant studies in which the management of intracranial meningiomas with preoperative embolization was reported. Immediate complications of embolization were reported as major (sustained) or minor (transient) deficits, death, or no neurological deficits.

Results
A total of 36 studies comprising 459 patients were included in the review. Among patients receiving preoperative embolization for meningiomas, 4.6% (n = 21) sustained complications as a direct result of embolization. Of the 21 patients with embolization-induced complications, the incidence of major complications was 4.8% (n = 1) and the mortality rate was 9.5% (n = 2).

Conclusions
Preoperative embolization is associated with an added risk for morbidity and mortality. Preoperative embolization may be associated with significant complications, but careful selection of ideal cases for embolization may help reduce any added morbidity with this procedure. Although not analyzed in the authors' study, embolization may still reduce rates of surgical morbidity and mortality and therefore may still have a potential benefit for selected patients. Future prospective studies involving the use of preoperative embolization in certain cases of meningiomas may further elucidate its potential benefit and risks.
Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity
Authors: Rodriguez Patricia J. , Goodwin Cartwright Brianna M. , Gratzl Samuel , Brar Rajdeep , Baker Charlotte , Gluckman Ty J. , Stucky Nicholas L. 
Published: July 2024

ImportanceAlthough tirzepatide and semaglutide were shown to reduce weight in randomized clinical trials, data from head-to-head comparisons in populations with overweight or obesity are not yet available.ObjectiveTo compare on-treatment weight loss and rates of gastrointestinal adverse events (AEs) among adults with overweight or obesity receiving tirzepatide or semaglutide labeled for type 2 diabetes (T2D) in a clinical setting.Design, Setting, and ParticipantsIn this cohort study, adults with overweight or obesity receiving semaglutide or tirzepatide between May 2022 and September 2023 were identified using electronic health record (EHR) data linked to dispensing information from a collective of US health care systems. On-treatment weight outcomes through November 3, 2023, were assessed. Adults with overweight or obesity and regular care in the year before initiation, no prior glucagon-like peptide 1 receptor agonist receptor agonist use, a prescription within 60 days prior to initiation, and an available baseline weight were identified. The analysis was completed on April 3, 2024.ExposuresTirzepatide or semaglutide in formulations labeled for T2D, on or off label.Main Outcomes and MeasuresOn-treatment weight change in a propensity score–matched population, assessed as hazard of achieving 5% or greater, 10% or greater, and 15% or greater weight loss, and percentage change in weight at 3, 6, and 12 months. Hazards of gastrointestinal AEs were compared.ResultsAmong 41 222 adults meeting the study criteria (semaglutide, 32 029; tirzepatide, 9193), 18 386 remained after propensity score matching. The mean (SD) age was 52.0 (12.9) years, 12 970 were female (70.5%), 14 182 were white (77.1%), 2171 Black (11.8%), 354 Asian (1.9%), 1679 were of other or unknown race, and 9563 (52.0%) had T2D. The mean (SD) baseline weight was 110 (25.8) kg. Follow-up was ended by discontinuation for 5140 patients (55.9%) receiving tirzepatide and 4823 (52.5%) receiving semaglutide. Patients receiving tirzepatide were significantly more likely to achieve weight loss (≥5%; hazard ratio [HR], 1.76, 95% CI, 1.68, 1.84; ≥10%; HR, 2.54; 95% CI, 2.37, 2.73; and ≥15%; HR, 3.24; 95% CI, 2.91, 3.61). On-treatment changes in weight were larger for patients receiving tirzepatide at 3 months (difference, −2.4%; 95% CI −2.5% to −2.2%), 6 months (difference, −4.3%; 95% CI, −4.7% to −4.0%), and 12 months (difference, −6.9%; 95% CI, −7.9% to −5.8%). Rates of gastrointestinal AEs were similar between groups.Conclusions and RelevanceIn this population of adults with overweight or obesity, use of tirzepatide was associated with significantly greater weight loss than semaglutide. Future study is needed to understand differences in other important outcomes.
PdZn/CoSA‐NC Nanozymes with Highly Efficient SOD/CAT Activities for Treatment of Osteoarthritis via Regulating Immune Microenvironment
Authors: Yang Xin , Tan Manli , Guo Jianfeng , Xiang Jianhui , Yin Feiying , Deng Jiejia , Luo Ji , Xiao Shihui , Mo Miao , Wang Hanjie , Zhao Jinmin , Zheng Li , Cheng Jianwen , Zhong Jingping 
Published: July 2024

AbstractInflammatory infiltration of synovial M1 macrophages, high levels of ROS, and NO exacerbate osteoarthritis (OA) progression. The PdZn/CoSA‐NC nanozymes, which are highly ordered PdZn intermetallic nanoparticles loaded with Co single atom N‐doped carbon‐rich in multi‐level pores, in an attempt to serve as SOD and CAT mimicking nanozymes for OA therapy is designed. The PdZn/CoSA‐NC nanozymes' high electron transfer and dual active site sufficient exposure enhances free radical adsorption and lower reaction energies, accelerating SOD‐like, CAT‐like, and GPx‐like catalyzed reactions, outperforming CoSA‐NC and PdZn/NC alone. Furthermore, PdZn/CoSA‐NC nanozymes exhibit favorable biocompatibility, reduce synovial macrophage oxidative stress in OA, alleviate hypoxia, restore mitochondrial function, regulate energy metabolism, increase antioxidant factors, and reduce inflammatory factors, thus effectively mitigating the progression of OA. Mechanistically, PdZn/CoSA‐NC nanozymes downregulate M1‐type phenotypic markers like IL‐1β by regulating purine metabolism. The PdZn/CoSA‐NC nanozymes offer a novel approach to treating oxidative stress‐related inflammatory diseases.
Matrix Assisted Assembly of Protocells into Multi‐responsive Prototissues for Mechanical and Chemical Communication
Authors: Naz Mehwish , Mukwaya Vincent , Yang Shuo , Xiong Shuhan , Cruz Jackeline Soto , Yu Xiaolei , Tian Zhengtao , Dou Hongjing 
Published: July 2024

AbstractThe extracellular matrix (ECM) provides an integrated 3D environment for living cells to communicate and display collective behaviors. In bottom‐up synthetic biology, several new types of synthetic prototissues (assemblies of synthetic protocells) are developed to mimic various aspects of cellular signaling. However, the spatiotemporal interplay between supporting matrix and protocells, which is critical for mimicking macroscopic responsiveness of multicellular organisms, has remained challenging to control. Herein, a modular strategy is reported to construct macroscopic prototissues with complex structures based on hierarchical assembly of matrix and polymeric protocells prepared by using CaCO3 sacrificial microparticle templates. Mechanical coordination between protocells and matrix allows for the transformation in response to both the presence and history of multiple stimuli. Taking advantage of the multi‐responsiveness, it further demonstrated an artificial form of metabolic behaviors where a digestive prototissue prey on a substrate‐containing prototissue by two‐way communication. Overall, the methodology presents a strategy to achieve mechanical and chemical communication in matrix containing, tissue‐like materials harboring the potential to reconstitute collective behaviors for bottom‐up synthetic biology and bioinspired engineering.
Temperature‐Responsive Polyoxometalates‐Based Materials: From Underlying Mechanism to Promising Applications
Authors: Wang Yuanyu , Yu Zhihao , Xiong Jian , Yan Kai , Lu Xuebin 
Published: July 2024

AbstractPolyoxometalates (POMs) are multifunctional anionic metal‐oxygen complexes with structural and electronic diversity, as well as tunable acid‐base and redox properties, resulting in their potential as building blocks for constructing temperature‐responsive polyoxometalates‐based materials (TRPMs). TRPMs represent a class of intelligent materials exhibiting property changes in response to temperature fluctuations, offering distinctive applications in various fields such as catalysis, medicine, sensors, imaging, and so on. Though many TRPMs are reported, a systematic review including recent advances is still absent. This review provides insights into recent advancements in temperature‐responsive mechanisms, nanostructure design strategies, and the characterization of TRPMs. Special emphasis is placed on enhancing the temperature‐responsive properties of TRPMs by incorporating POMs into suitable organic ligands, such as ionic liquid cations, deep eutectic solvent cations, cationic surfactants, and polymers. The incorporation of organic ligands with POMs not only enables temperature‐responsive phase transitions but also enhances other properties, such as catalyst selectivity and drug loading capacity, expanding TRPMs applications. Consequently, this review summarizes the applications of TRPMs in catalysis, drug delivery and release, and chemical sensing, as well as discusses future technological challenges. The in‐depth understanding of TRPMs may help in the design of TRPMs from the nanoscale, guiding and inspiring future development.
Room‐Temperature Out‐of‐Plane Ferroelectricity and Resistance Switching Based on 2D Bi2O2Se
Authors: Tang Lei , Dang Le‐Yang , Han Mengjiao , Li Shengnan , Khan Usman , Chen Wenjun , Cai Zhengyang , Kong Lingan , Wu Qinke , Liu Bilu , Zhang Qichong , Xu Runzhang , Ma Xiu‐Liang 
Published: July 2024

AbstractAlthough 2D Bi2O2Se plays an important role in the electronics and optoelectronics based on its in‐plane property, its out‐of‐plane electrical transport behavior remains unclear, especially in fabricating vertical devices with high integration density for novel functionality. Here, a solution‐processed method is developed to prepare 2D Bi2O2Se with mass production (e.g., hundreds of milliliter scale). The out‐of‐plane ferroelectric property of 2D Bi2O2Se is observed by piezoresponse force microscopy and the ferroelectric dipole map atom‐by‐atom at the Bi2O2Se surface, which shows an atomically resolved dipolar displacement of Se ions. The out‐of‐plane resistant switching property of 2D Bi2O2Se is revealed by conductive atomic force microscopy. Moreover, the electric field on the local polarization of Bi2O2Se is addressed by using ab initio simulations, which shows a broken inversion symmetry along the z‐axis of Bi2O2Se. The working mechanism of resistant switching behavior in Bi2O2Se is attributed to the diffusion and shuttle of Se ions. Besides, a controllable wet‐assembled method is developed to prepare Bi2O2Se thin film with centimeter scale and explores its application on photodetectors under 808 nm laser light. This work reveals the unique out‐of‐plane transport behavior of 2D Bi2O2Se, providing the basis for fabricating multifunctional devices with high integration based on this 2D material.
A Highly Stable, Multifunctional Janus Dressing for Treating Infected Wounds
Authors: Deng Jixia , Hu Miao , Cai Zhuyun , Yu Wenhua , Zhan Lei , Zhu Xueying , Ke Qinfei , Gao Rui , Zhou Xuhui , Liu Honggang , Li Juan , Huang Chen 
Published: July 2024

AbstractThe limited and unstable absorption of excess exudate is a major challenge during the healing of infected wounds. In this study, a highly stable, multifunctional Janus dressing with unidirectional exudate transfer capacity is fabricated based on a single poly(lactide caprolactone) (PLCL). The success of this method relies on an acid hydrolysis reaction that transforms PLCL fibers from hydrophobic to hydrophilic in situ. The resulting interfacial affinity between the hydrophilic/phobic PLCL fibers endows the Janus structure with excellent unidirectional liquid transfer and high structural stability against repeated stretching, bending, and twisting. Various other functions, including wound status detection, antibacterial, antioxidant, and anti‐inflammatory properties, are also integrated into the dressing by incorporating phenol red and epigallocatechin gallate. An in vivo methicillin‐resistant Staphylococcus aureus‐infected wound model confirms that the Janus dressing, with the capability to remove exudate from the infected site, not only facilitates epithelialization and collagen deposition, but also ensures low inflammation and high angiogenesis, thus reaching an ideal closure rate up to 98.4% on day 14. The simple structure, multiple functions, and easy fabrication of the dressing may offer a promising strategy for treating chronic wounds, rooted in the challenges of bacterial infection, excessive exudate, and persistent inflammation.
Vertically Phase Separated Photomultiplication Organic Photodetectors with p‐n Heterojunction Type Ultrafast Dynamic Characteristics
Authors: Kim Myeong In , Lee Soonyong , Kang Jinhyeon , Kim Jaehyeong , Wu Ziang , Won Jong Ho , Baek Seyeon , Chung Dae Sung , Kim Jin Young , Jung In Hwan , Woo Han Young 
Published: July 2024

AbstractPhotomultiplication (PM)‐type organic photodetectors (OPDs), which typically form a homogeneous distribution (HD) of n‐type dopants in a p‐type polymer host (HD PM‐type OPDs), have achieved a breakthrough in device responsivity by surpassing a theoretical limit of external quantum efficiency (EQE). However, they face limitations in higher dark current and slower dynamic characteristics compared to p‐n heterojunction (p‐n HJ) OPDs due to inherent long lifetime of trapped electrons. To overcome this, a new PM‐type OPD is developed that demonstrates ultrafast dynamic properties through a vertical phase separation (VPS) strategy between the p‐type polymer and n‐type acceptor, referred to as VPS PM‐type OPDs. Notably, VPS PM‐type OPDs show three orders of magnitude increase in −3 dB cut‐off frequency (120 kHz) and over a 200‐fold faster response time (rising time = 4.8 µs, falling time = 8.3 µs) compared to HD PM‐type OPDs, while maintaining high EQE of 1121% and specific detectivity of 2.53 × 1013 Jones at −10 V. The VPS PM‐type OPD represents a groundbreaking advancement by demonstrating the coexistence of p‐n HJ and PM modes within a single photoactive layer for the first time. This innovative approach holds the potential to enhance both static and dynamic properties of OPDs.
Fusing Science with Industry: Perovskite Photovoltaics Moving Rapidly into Industrialization
Authors: Wei Qingyun , Zheng Dexu , Liu Lu , Liu Jishuang , Du Minyong , Peng Lei , Wang Kai , Liu Shengzhong 
Published: July 2024

AbstractThe organic–inorganic lead halide per materials have emerged as highly promising contenders in the field of photovoltaic technology, offering exceptional efficiency and cost‐effectiveness. The commercialization of perovskite photovoltaics hinges on successfully transitioning from lab‐scale perovskite solar cells to large‐scale perovskite solar modules (PSMs). However, the efficiency of PSMs significantly diminishes with increasing device area, impeding commercial viability. Central to achieving high‐efficiency PSMs is fabricating uniform functional films and optimizing interfaces to minimize energy loss. This review sheds light on the path toward large‐scale PSMs, emphasizing the pivotal role of integrating cutting‐edge scientific research with industrial technology. By exploring scalable deposition techniques and optimization strategies, the advancements and challenges in fabricating large‐area perovskite films are revealed. Subsequently, the architecture and contact materials of PSMs are delved while addressing pertinent interface issues. Crucially, efficiency loss during scale‐up and stability risks encountered by PSMs is analyzed. Furthermore, the advancements in industrial efforts toward perovskite commercialization are highlighted, emphasizing the perspective of PSMs in revolutionizing renewable energy. By highlighting the scientific and technical challenges in developing PSMs, the importance of combining science and industry to drive their industrialization and pave the way for future advancements is stressed.
Phase Separation and Aggregation of α‐Synuclein Diverge at Different Salt Conditions
Authors: Sternke‐Hoffmann Rebecca , Sun Xun , Menzel Andreas , Pinto Miriam Dos Santos , Venclovaite Urte , Wördehoff Michael , Hoyer Wolfgang , Zheng Wenwei , Luo Jinghui 
Published: July 2024

AbstractThe coacervation of alpha‐synuclein (αSyn) into cytotoxic oligomers and amyloid fibrils are considered pathological hallmarks of Parkinson's disease. While aggregation is central to amyloid diseases, liquid–liquid phase separation (LLPS) and its interplay with aggregation have gained increasing interest. Previous work shows that factors promoting or inhibiting aggregation have similar effects on LLPS. This study provides a detailed scanning of a wide range of parameters, including protein, salt and crowding concentrations at multiple pH values, revealing different salt dependencies of aggregation and LLPS. The influence of salt on aggregation under crowding conditions follows a non‐monotonic pattern, showing increased effects at medium salt concentrations. This behavior can be elucidated through a combination of electrostatic screening and salting‐out effects on the intramolecular interactions between the N‐terminal and C‐terminal regions of αSyn. By contrast, this study finds a monotonic salt dependence of LLPS due to intermolecular interactions. Furthermore, it observes time evolution of the two distinct assembly states, with macroscopic fibrillar‐like bundles initially forming at medium salt concentration but subsequently converting into droplets after prolonged incubation. The droplet state is therefore capable of inhibiting aggregation or even dissolving aggregates through heterotypic interactions, thus preventing αSyn from its dynamically arrested state.
EGR3 Inhibits Tumor Progression by Inducing Schwann Cell‐Like Differentiation
Authors: Chen Cai‐hong , Chen Yang , Li Yi‐nan , Zhang Heng , Huang Xiu , Li Ying‐ying , Li Zhi‐yang , Han Jing‐xia , Wu Xin‐ying , Liu Hui‐juan , Sun Tao 
Published: July 2024

AbstractThe mechanism and function of the expression of Schwann characteristics by nevus cells in the mature zone of the dermis are unknown. Early growth response 3 (EGR3) induces Schwann cell‐like differentiation of melanoma cells by simulating the process of nevus maturation, which leads to a strong phenotypic transformation of the cells, including the formation of long protrusions and a decrease in cell motility, proliferation, and melanin production. Meanwhile, EGR3 regulates the levels of myelin protein zero (MPZ) and collagen type I alpha 1 chain (COL1A1) through SRY‐box transcription factor 10 (SOX10)‐dependent and independent mechanisms, by binding to non‐strictly conserved motifs, respectively. Schwann cell‐like differentiation demonstrates significant benefits in both in vivo and clinical studies. Finally, a CD86‐P2A‐EGR3 recombinant mRNA vaccine is developed which leads to tumor control through forced cell differentiation and enhanced immune infiltration. Together, these data support further development of the recombinant mRNA as a treatment for cancer.
Ti3C2Tx MXene‐Decorated 3D‐Printed Ceramic Scaffolds for Enhancing Osteogenesis by Spatiotemporally Orchestrating Inflammatory and Bone Repair Responses
Authors: Huang Benzhao , Li Shishuo , Dai Shimin , Lu Xiaoqing , Wang Peng , Li Xiao , Zhao Zhibo , Wang Qian , Li Ningbo , Wen Jie , Liu Yifang , Wang Xin , Man Zhentao , Li Wei , Liu Bing 
Published: July 2024

AbstractInflammatory responses play a central role in coordinating biomaterial‐mediated tissue regeneration. However, precise modulation of dynamic variations in microenvironmental inflammation post‐implantation remains challenging. In this study, the traditional β‐tricalcium phosphate‐based scaffold is remodeled via ultrathin MXene‐Ti3C2 decoration and Zn2+/Sr2+ ion‐substitution, endowing the scaffold with excellent reactive oxygen species‐scavenging ability, near‐infrared responsivity, and enhanced mechanical properties. The induction of mild hyperthermia around the implant via periodic near‐infrared irradiation facilitates spatiotemporal regulation of inflammatory cytokines secreted by a spectrum of macrophage phenotypes. The process initially amplifies the pro‐inflammatory response, then accelerates M1‐to‐M2 macrophage polarization transition, yielding a satisfactory pattern of osteo‐immunomodulation during the natural bone healing process. Later, sustained release of Zn2+/Sr2+ ions with gradual degradation of the 3D scaffold maintains the favorable reparative M2‐dominated immunological microenvironment that supports new bone mineralization. Precise temporal immunoregulation of the bone healing process by the intelligent 3D scaffold enhances bone regeneration in a rat cranial defect model. This strategy paves the way for the application of β‐tricalcium phosphate‐based materials to guide the dynamic inflammatory and bone tissue responses toward a favorable outcome, making clinical treatment more predictable and durable. The findings also demonstrate that near‐infrared irradiation‐derived mild hyperthermia is a promising method of immunomodulation.
Multifunctional Biomimetic Nanocarriers for Dual‐Targeted Immuno‐Gene Therapy Against Hepatocellular Carcinoma
Authors: Sun Yupeng , Liu Yan , Li Rui , Zhang Cuilin , Wu Ming , Zhang Xiaolong , Zheng Aixian , Liao Naishun , Zheng Youshi , Xu Haipo , Zeng Rui , Zeng Yongyi , Liu Xiaolong 
Published: July 2024

AbstractGrowing evidences have proved that tumors evade recognition and attack by the immune system through immune escape mechanisms, and PDL1/Pbrm1 genes have a strong correlation with poor response or resistance to immune checkpoint blockade (ICB) therapy. Herein, a multifunctional biomimetic nanocarrier (siRNA‐CaP@PD1‐NVs) is developed, which can not only enhance the cytotoxic activity of immune cells by blocking PD1/PDL1 axis, but also reduce tumor immune escape via Pbrm1/PDL1 gene silencing, leading to a significant improvement in tumor immunosuppressive microenvironment. Consequently, the nanocarrier promotes DC cell maturation, enhances the infiltration and activity of CD8+ T cells, and forms long‐term immune memory, which can effectively inhibit tumor growth or even eliminate tumors, and prevent tumor recurrence and metastasis. Overall, this study presents a powerful strategy for co‐delivery of siRNA drugs, immune adjuvant, and immune checkpoint inhibitors, and holds great promise for improving the effectiveness and safety of current immunotherapy regimens.