bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genealogías, migración, educación superior y género en el Istmo de Tehuantepec, Oaxaca
Authors: Rea-Ángeles Patricia 
Published: June 2024

Este artículo analiza las relaciones sociales, familiares y de paisanaje entre una comunidad zapoteca del Istmo de Tehuantepec y las principales ciudades a donde emigran para escolarizarse a nivel superior. Al mismo tiempo, muestra las transformaciones en las relaciones de género que se han suscitado como resultado de estos procesos migratorios con fines educativos.
Este trabajo se enmarca en una investigación de largo aliento sobre el tema, realizada en un primer momento, para mi tesis de licenciatura y maestría, y posteriormente para el desarrollo de mi tesis doctoral del año 2009 al año 2013. Asimismo, en las investigaciones intermitentes que he llevado a cabo hasta la fecha, cuyos resultados se expresan en diversos artículos y capítulos de libro.
Se inscribe dentro de los estudios de la antropología de la educación y se fundamenta en la perspectiva de análisis propuesta por María Bertely (1997, 1998, 2004, 2019) sobre procesos de escolarización, etnogénesis, autonomía de facto, y enfoque sincrónico/diacrónico, para entender cómo procesos micro y comunitarios, aparentemente aislados en el tiempo, se conectan a procesos estructurales, macrosociales, de carácter global y de largo aliento, como es la escuela, en su sentido más amplio. La metodología está basada en el uso de la genealogía, la etnografía, la entrevista y la observación participante como herramientas clásicas de la antropología.
Entre los resultados encontramos que el acceso al dispositivo escolar, y específicamente a la educación superior, funge como herramienta para la obtención, manipulación y preservación de la ciudadanía étnica; para la transformación de las identidades étnicas y genéricas; y la formación de alianzas estratégicas con el Estado-nación y sus políticas gubernamentales. En ese sentido, el trabajo representa un estudio original, al analizar los casos de las familias letradas zapotecas de clase media y alta, escasos en la antropología mexicana. No obstante, veremos que contar con privilegios de clase no exime a los zapotecos de experimentar racismo, discriminación y desigualdades de género en los contextos de la migración.
Crédito a pequeños productores de maíz en regiones lacustres de Michoacán
Authors: González Pérez José Manuel , López-Paniagua Rosalía 
Published: June 2024

El objetivo de este trabajo es analizar el nivel de acceso al crédito público de los pequeños productores de maíz en las regiones lacustres de Chapala, Pátzcuaro y Cuitzeo en el estado de Michoacán, en el marco de la política financiera de corte neoliberal adoptada en los años 1981-2022 en comparación con el periodo posrevolucionario. Este sector productivo se caracteriza principalmente por tener bajos ingresos económicos, disponer de poca superficie de tierra y carencia de equipo y maquinaria y no ser sujeto de crédito, por lo que los integrantes de dicho sector comparten la condición de exclusión al financiamiento para la producción.
La metodología empleada consistió en recabar información histórica respecto a la operación de las instituciones financieras rurales públicas creadas en el periodo posrevolucionario y la transición neoliberal que experimentaron en los años ochenta. También en la obtención de datos mediante la aplicación de 611 encuestas para identificar algunos elementos que expliquen la actual exclusión al crédito púbico de los pequeños productores de maíz en las regiones lacustres de Michoacán. Los resultados revelan que este sector productivo tiene un bajo nivel de acceso, condición que obedece a los cambios de la política pública crediticia impulsados por los gobiernos federales desde la década de los noventa. Estos provocaron modificaciones institucionales radicales en la forma de operar el crédito agrícola y contribuyeron a que actualmente se presente una escasa disposición de crédito público dirigido a los pequeños productores de maíz.
Aportes de María Bertely Busquets a la Historiografía de la Educación Mexicana
Authors: Alfonseca Giner de los Ríos Juan Bernardo 
Published: June 2024

El escrito se aboca a situar la trayectoria y aportes realizados por María Bertely Busquets en el campo de la investigación histórica sobre la educación mexicana con el propósito de destacar una faceta de su actividad intelectual poco conocida pero muy importante para ella. La edición de La División es nuestra fuerza. Escuela, Estado-nación y poder étnico en un pueblo migrante de Oaxaca, su gran trabajo póstumo, constituye el eje del recuento de su participación y aportes a la historiografía de la educación en el país. Pero, además, sirve para situar un prolongado proceso constructivo precedido de acercamientos a la historia y a la historización de la cultura de la escuela y sus agentes desde la práctica etnográfica, que después da paso a la profundización y desarrollo del método antropológico-histórico que despliega en la obra. Como una reflexión final, se destaca la importancia de acercar los trabajos y fomentar el intercambio intelectual entre antropólogos e historiadores de la educación.
La influenza española de 1918 en Chiapas desde la perspectiva del framing
Authors: Martínez Mendoza Sarelly , Lisbona Guillén Miguel 
Published: June 2024

Este texto analiza, desde la perspectiva del framing, la forma en que los periódicos enmarcaron la “influenza española” que padecieron los habitantes de Chiapas en 1918. Se encontró que en un principio trataron de minimizar la letalidad de la enfermedad, pero cuando los fallecidos incrementaron y se comprobó la gravedad de la situación, destacaron las medidas dictadas por las autoridades políticas y sanitarias, la solidaridad generada y, de forma marginal, las consecuencias económicas. El frame que más se empleó fue de interés humano, seguido por el de soluciones/recomendaciones y de atribución de responsabilidad, en un contexto en el que Chiapas vivía enfrentamientos militares, aunque ya disminuidos, de la Revolución mexicana.
Spēle
Authors: Sīle Vija 
Published: June 2024

Vija Sīle’s paper “Play” is a study of a phenomenon of play and its role in human creativity. / Vija Sīle rakstā “Spēle” turpina aplūkot cilvēku kā kultūrradošu būtni. Spēle ir eksistenciāla vajadzība un vienlaikus viens no socializācijas līdzekļiem, ar kura palīdzību cilvēks apgūst kultūru veidojošās nozīmes. Rakstā aplūkota klasiskā J. Heizingas teorija, kurā cilvēks raksturots kā Homo ludens – būtne, kas pašrealizējas ar spēles palīdzību. Spēles pazīmes ir brīva darbība, atrautība no ikdienas dzīves, telpiskā izolētība. Savukārt R. Kaijuā teorija papildina šo uzskaitījumu ar to, ka spēle ir ar neprognozējamu rezultātu, tā neko neražo, ir pakļauta savai īpašajai spēles realitātei un ir fiktīva salīdzinājumā ar ikdienas dzīvi. Psihologa E. Berna spēles teorija aplūko spēli kā sociālā kontakta formu – noteiktas lomas realizāciju. Spēle ir nepārtrauktu, papildinošu, slēptu transakciju sērija ar prognozējamu rezultātu. Savukārt Ē. Gofmanis lieto dramaturģisko pieeju – viņa teorijā spēle tiek skatīta caur “izrādes” metaforu – uzvedību nosaka aktiera atrašanās uz skatuves, aiz skatuves utt. Nobeigumā V. Sīle secina, ka spēle ir specifisks realitātes un iedomātā sajaukums, tādēļ daudzos gadījumos ir grūti nošķirt spēles situāciju no ne-spēles situācijas. Var teikt, ka dzīves māksla vienlaikus ir arī māksla spēlēt. 6.3. Filozofija, reliģija, ētika. Filozofiskās antropoloģijas apakšnozare. Atslēgvārdi: spēles jēdziens; homo ludens; transakcija; E. Berns; Ē. Gofmanis; J. Heizinga; māksla; simbols; svētki; sevis izrādīšana.
Dzīvesmāksla
Authors: Bitiniece Laura 
Published: June 2024

In Laura Bitiniece’s paper “Art of Living”, two modern-day stories set the tone for continuous and fundamental human questions: what constitutes a good human life and what the ways of reaching it are. The answer is searched upon in the teachings of the so-called Ancient Greek schools of philosophy – cynics, stoics, epicureans and skeptics. / Filosofija mūsdienās ierasti tiek uzskatīta par teorētisku un no ikdienas dzīves tālu stāvošu disciplīnu. Tomēr šāds priekšstats ir nepatiess. Jau kopš filosofijas pirmsākumiem tā ir bijusi saistīta ar jautājumu, kā cilvēkam dzīvot savu dzīvi, un šis jautājums ir bijis svarīgs ne tikai antīko Atēnu iedzīvotājam, bet arī cilvēkiem vēl joprojām. Laura Bitiniece rakstā “Dzīvesmāksla” pievēršas tieši šim filosofijas aspektam. Autore sniedz ieskatu četru antīko filosofijas skolu (kiniķu, skeptiķu, epikūriešu un stoiķu) uzskatos un, atsaucoties uz ievērojamo antīkās filosofijas pētnieku Pjēru Ado, apraksta šo skolu izstrādātās garīgo vingrinājumu tehnikas. Nobeigumā L. Bitiniece pievēršas mūsdienās pastāvošajai paradoksālajai attieksmei pret vienatni, radošumu un sasniegumiem. 6.3. Filozofija, reliģija, ētika. Filozofiskās antropoloģijas apakšnozare. Atslēgvārdi: dzīves māksla; stoicisms; kiniķi; skeptiķi; epikūrieši; garīgie vingrinājumi; P. Ado; self-help.
Biotransformation of anabolic drug Dianabol with Rizhopus oryzae
Authors: M. Siddiqui  , Atia-tul-Wahab  , Kudaibergenova B.M. , Zh.A. Abilov  , M.I. Choudhary  
Published: June 2024

Microbial biotransformation technique is an excellent approach for the synthesis of stereo-, enantio-, chemo-, and regio-selective/specific analogues of existing steroidal and non-steroidal drugs by using bacteria, fungi, algae, actinomycetes, yeast, and plants and animals cell cultures. This technique is effectively used to synthesize compounds whose structures resemble to the substrates (parent drugs) without using protecting/deprotecting steps. In the current study, an anabolic-androgenic steroid (AAS) based drug, methandienone (dianabol) (1) was incubated with the filamentous fungi Rhizopus oryzae ATCC 11145 for twelve days under ambient reaction conditions (at room temperature and neutral pH) by using aqueous media. Therefore, the present study has successfully helped to produce the structural analogues of inert steroidal anabolic drug dianabol (1) without using expensive and toxic chemicals. This yielded five known structural analogues of dianabol (1), i.e., 17β,11β-dihydroxy,17α-methyl-androsta-1,4-diene-3-one (2), 17β-hydroxy,17α-methyl-androsta-1,4-diene-3,11-dione (3), 17β,6β-dihydroxy,17α-methyl-androsta-1,4-diene-3-one (4), 17β,6β-dihydroxy,17α-methyl-androsta-4-ene-3-one (5), and 17β-hydroxy,17α-methyl-androsta-4,6-diene-3-one (6). Structures of transformed products 2-6 were determined through 1H-NMR, and FAB-MS spectroscopic techniques.
Applications to Support Smart Learning Environments in Project-Based Cooperative Learning Models in Java Programming Courses and Applied in Science
Authors: Melyanti Rika , Ayu Fitri , Mardainis Mardainis , Henda Zupri , Herianto Herianto 
Published: June 2024

This research paper proposes the development of an application to support an intelligent learning environment in a project-based cooperative learning model on Java programming courses. The application is built using the Laravel framework where the end result later lecturers can easily see the student portfolio of each learning access on the java programming course. An intelligent learning environment will enable students to learn from their experiences, adapt to new input, and perform project tasks already assigned to lecturers. This application will also help teachers in groups that are adapted from the cooperative learning model of the STAD type. The proposed application will be designed to make it easier for teachers to form groups based on the ability of students from high, medium and low, so that the groups formed are not homogeneous groups. This application will be useful for a variety of study programmer that have practical programming courses devised. This paper will discuss the benefits of cooperative learning, project-based learning, and intelligent learning environments in the context of Java programming courses. It will also provide insights into the proposed application development process. This application facilitates communication and discussion among students in a group that is easily connected with their lecturer, so that the lecturer can also monitor the activity of the group members. This paper will conclude with a discussion of the potential impact of the proposed applications on the field of education and the future in the learning environment.
Rancang Bangun Sistem Catu Daya Robot Pengaduk Proses Pengeringan Biji Kakao pada Solar Dryer dan Box Dryer
Authors: Mukhtar Mukhtar , Muhammad Abdul Kadir , Rahgita Wening Widowati , Nurjannah Nurjannah 
Published: June 2024

Proses pengeringan biji kakao hingga saat ini masih menggunakan sumber daya yang terbilang masih terbatas yakni menggunakan tenaga manusia secara terus menerus hingga 2 hari. Kemudian, dikarenakan masih bersifat tradisional maka pengeringan biji kakao masih kurang meratadan pengeringan biji kakao tidak mencapai 100%. Hal ini terjadi karena aktivitas pengeringan dapat dipengaruhi oleh faktor human error. Masalah ini dapat diatasi dengan menggunakan robot pengaduk pada proses pengeringan biji kakao, yang mana nantinya kan mempermudah proses pengeringan serta penggunaan sumber energi yang efektif karena menggunakan sumber tenanga utama dari solar panel. Penelitian ini dilakukan untuk mendapatkan biji kakao yang kering dengan kadar air 7 % - 8 % agar dapat diolah menjadi bahan makanan. Selain itu, penelitian ini bertujuan meningkatkan efektifitas pengeringan para petani kakao dan mendapatkan produk/hasil yang unggul. Sehubungan dengan itu, penelitian ini diawali dengan perakitan baterai, perancangan dan spesifikasi sistem catu daya, dan perancangan automatic charging terhadap sumber PLN ketika kapasitas baterai tidak dapat dipenuhi oleh solar panel. Pengumpulam data dilakukan dengan (teknik) pengujian, sedangkan analisis data dilakukan dengan regresi sederhana. Berdasarkan hasil penelitian dan pembahasan dapat disimpulkan bahwa penggunaan robot pengaduk dapat meninggkatakan kualitas biji kakao dan lebih efektif dalam penggunaannya . Bahkan, penggunaan alat ini lebih mneghemat daya listrik karena menggunakan sumber daya terbarukan dari solar panel.
Young children’s at-home digital experiences and interactions: an ethnographic study
Authors: Lewis K. L. , Kervin L. K. , Verenikina I. , Howard S. J. 
Published: June 2024

IntroductionYoung children are increasingly provided with opportunities to interact with digital technologies in their homes. Despite an accumulating body of research on children’s digital interactions, little is known about how these are situated within the social and cultural context in which they take place. In this exploratory study, we aim to extend existing knowledge by offering a contextualised understanding of children’s digital experiences. To do this, we draw on Activity Theory as a conceptual framework to explore how various social and cultural factors influence and interact to shape children’s opportunities and interactions with digital technologies.MethodThis study draws upon ethnographic and ‘day in the life’ methodologies to gain rich insight into children’s situated digital experiences. Along with other traditional ethnographic methodologies, children aged between 3 and 6 years from 5 families were provided with wearable chest-mounted video cameras to capture their usual daily play activities at home – which included, but was not limited to, digital activities.ResultsData on digital interactions is presented for the five participating families, and through the presentation of two purposively selected in-depth illustrative examples, we demonstrate how children’s digital interactions are part of a larger activity system situated within the social and cultural contexts of their homes. We also elaborate on children’s natural inclination to interact playfully with digital technologies.DiscussionThis study extends on current knowledges about the contextual influences of children’s digital experiences and has important implications for parents and families trying to navigate the complexities of their children’s digital lives.
Identification of ibuprofen targeting CXCR family members to alleviate metabolic disturbance in lipodystrophy based on bioinformatics and in vivo experimental verification
Authors: Cao Zhiwen , Zhao Yuxiao , Liu Ruixin , Yan Xialin , Wang Jiqiu , Chen Na 
Published: June 2024

BackgroundLipodystrophy is a rare disease that is poorly diagnosed due to its low prevalence and frequent phenotypic heterogeneity. The main therapeutic measures for patients with clinical lipodystrophy are aimed at improving general metabolic complications such as diabetes mellitus, insulin resistance, and hypertriglyceridemia. Therefore, there is an urgent need to find new biomarkers to aid in the diagnosis and targeted treatment of patients with congenital generalized lipodystrophy (CGL).MethodsDataset GSE159337 was obtained via the Gene Expression Omnibus database. First, differentially expressed genes (DEGs) between CGL and control samples were yielded via differential expression analysis and were analyzed for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment to explore the functional pathways. Next, protein–protein interaction analysis and the MCC algorithm were implemented to yield candidate genes, which were then subjected to receiver operating characteristic (ROC) analysis to identify biomarkers with an area under the curve value exceeding 0.8. Moreover, random forest (RF), logistic regression, and support vector machine (SVM) analyses were carried out to assess the diagnostic ability of biomarkers for CGL. Finally, the small-molecule drugs targeting biomarkers were predicted, and ibuprofen was further validated in lipodystrophy mice.ResultsA total of 71 DEGs in GSE159337 were sifted out and were involved in immune receptor activity, immune response-regulating signaling pathway, and secretory granule membrane. Moreover, CXCR2, TNFSF10, NLRC4, CCR2, CEACAM3, TLR10, TNFAIP3, and JUN were considered as biomarkers by performing ROC analysis on 10 candidate genes. Meanwhile, RF, logistic regression, and SVM analyses further described that those biomarkers had an excellent diagnosis capability for CGL. Eventually, the drug–gene network included ibuprofen–CXCR1, ibuprofen–CXCR1, cenicriviroc–CCR2, fenofibrate–JUN, and other relationship pairs. Ibuprofen treatment was also validated to downregulate CXCR1 and CXCR2 in peripheral blood mononuclear cells (PBMCs) and improve glucose tolerance, hypertriglyceridemia, hepatic steatosis, and liver inflammation in lipodystrophy mice.ConclusionEight biomarkers, namely, CXCR2, TNFSF10, NLRC4, CCR2, CEACAM3, TLR10, TNFAIP3, and JUN, were identified through bioinformatic analyses, and ibuprofen targeting CXCR1 and CXCR2 in PBMCs was shown to improve metabolic disturbance in lipodystrophy, contributing to studies related to the diagnosis and treatment of lipodystrophy.
Single-cell transcriptomic analysis identifies downregulated phosphodiesterase 8B as a novel oncogene in IDH-mutant glioma
Authors: He Zongze , Peng Yu , Wang Duo , Yang Chen , Zhou Chengzhi , Gong Bo , Song Siyuan , Wang Yi 
Published: June 2024

IntroductionGlioma, a prevalent and deadly brain tumor, is marked by significant cellular heterogeneity and metabolic alterations. However, the comprehensive cell-of-origin and metabolic landscape in high-grade (Glioblastoma Multiforme, WHO grade IV) and low-grade (Oligoastrocytoma, WHO grade II) gliomas remains elusive.MethodsIn this study, we undertook single-cell transcriptome sequencing of these glioma grades to elucidate their cellular and metabolic distinctions. Following the identification of cell types, we compared metabolic pathway activities and gene expressions between high-grade and low-grade gliomas.ResultsNotably, astrocytes and oligodendrocyte progenitor cells (OPCs) exhibited the most substantial differences in both metabolic pathways and gene expression, indicative of their distinct origins. The comprehensive analysis identified the most altered metabolic pathways (MCPs) and genes across all cell types, which were further validated against TCGA and CGGA datasets for clinical relevance.DiscussionCrucially, the metabolic enzyme phosphodiesterase 8B (PDE8B) was found to be exclusively expressed and progressively downregulated in astrocytes and OPCs in higher-grade gliomas. This decreased expression identifies PDE8B as a metabolism-related oncogene in IDH-mutant glioma, marking its dual role as both a protective marker for glioma grading and prognosis and as a facilitator in glioma progression.
Integration of single-cell sequencing with machine learning and Mendelian randomization analysis identifies the NAP1L1 gene as a predictive biomarker for Alzheimer's disease
Authors: Chen Runming , Xie Yujun , Chang Ze , Hu Wenyue , Han Zhenyun 
Published: June 2024

BackgroundThe most effective approach to managing Alzheimer's disease (AD) lies in identifying reliable biomarkers for AD to forecast the disease in advance, followed by timely early intervention for patients.MethodsTranscriptomic data on peripheral blood mononuclear cells (PBMCs) from patients with AD and the control group were collected, and preliminary data processing was completed using standardized analytical methods. PBMCs were initially segmented into distinct subpopulations, and the divisions were progressively refined until the most significantly altered cell populations were identified. A combination of high-dimensional weighted gene co-expression analysis (hdWGCNA), cellular communication, pseudotime analysis, and single-cell regulatory network inference and clustering (SCENIC) analysis was used to conduct single-cell transcriptomics analysis and identify key gene modules from them. Genes were screened using machine learning (ML) in the key gene modules, and internal and external dataset validations were performed using multiple ML methods to test predictive performance. Finally, bidirectional Mendelian randomization (MR) analysis, regional linkage analysis, and the Steiger test were employed to analyze the key gene.ResultA significant decrease in non-classical monocytes was detected in PMBC of AD patients. Subsequent analyses revealed the inherent connection of non-classical monocytes to AD, and the NAP1L1 gene identified within its gene module appeared to exhibit some association with AD as well.ConclusionThe NAP1L1 gene is a potential predictive biomarker for AD.
Investigating cognitive impairment, biopsychosocial barriers, and predictors of return to daily life among older stroke survivors
Authors: Björck Alexandra , Matérne Marie , Arvidsson Lindvall Mialinn , Jarl Gustav 
Published: June 2024

PurposeThe aim was to investigate the associations between cognitive impairment and biopsychosocial factors among older stroke survivors and predictors of poststroke return to daily life.Materials and methodsThis cross-sectional study involved 117 stroke survivors (61% men) with an average age of 77 years (range 65–91). The participants completed two questionnaires (Riksstroke and Short Form 36 questionnaires). The Montreal Cognitive Assessment (MoCA) was used to assess cognitive abilities. The International Classification of Functioning, Disability, and Health (ICF) framework guided the selection of biopsychosocial variables. We used Spearman’s correlation coefficient and multiple logistic regression in the analyses.ResultsThe average MoCA score was 21.7 points (range: 4–30, SD 5.6). The need for assistance from relatives and professionals, need for help with dressing and household chores, reliance on others for mobility, and reading and balance problems were correlated with more severe cognitive impairment (r = 0.20–0.33). Cognitive impairment, fatigue, and balance issues predicted an unfavorable return to daily life (odds ratio: 6.2–6.8).ConclusionThe study indicated that cognitive impairment is associated with difficulties in all ICF domains. Cognitive impairment, fatigue, and balance issues are associated with an unsuccessful return to daily life. Prioritizing these factors and screening for cognitive impairment with objective assessment tools may improve rehabilitation outcomes and enhance overall quality of life poststroke.