bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viral and non‐viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children
Authors: Havens Tara N. , LeBeau Petra , Calatroni Agustin , Gern James E. , O'Connor George T. , Wood Robert A. , Lamm Carin , Krouse Rebecca Z. , Visness Cynthia M. , Gergen Peter J. , Jackson Daniel J. , Bacharier Leonard B. 
Published: July 2024

AbstractBackgroundViral wheezing is an important risk factor for asthma, which comprises several respiratory phenotypes. We sought to understand if the etiology of early‐life wheezing illnesses relates to childhood respiratory and asthma phenotypes.MethodsData were collected prospectively on 429 children in the Urban Environment and Childhood Asthma (URECA) birth cohort study through age 10 years. We identified wheezing illnesses and the corresponding viral etiology (PCR testing of nasal mucus) during the first 3 years of life. Six phenotypes of respiratory health were identified at 10 years of age based on trajectories of wheezing, allergic sensitization, and lung function. We compared the etiology of early wheezing illnesses to these wheezing respiratory phenotypes and the development of asthma.ResultsIn the first 3 years of life, at least one virus was detected in 324 (67%) of the 483 wheezing episodes documented in the study cohort. Using hierarchical partitioning we found that non‐viral wheezing episodes accounted for the greatest variance in asthma diagnosed at both 7 and 10 years of age (8.0% and 5.8% respectively). Rhinovirus wheezing illnesses explained the most variance in respiratory phenotype outcome followed by non‐viral wheezing episodes (4.9% and 3.9% respectively) at 10 years of age.Conclusion and RelevanceWithin this high‐risk urban‐residing cohort in early life, non‐viral wheezing episodes were frequently identified and associated with asthma development. Though rhinovirus wheezing illnesses had the greatest association with phenotype outcome, the specific etiology of wheezing episodes in early life provided limited information about subsequent wheezing phenotypes.
Food insecurity: The resilient, but “silent poverty” perspectives of older ethnic minority individuals within UK communities
Authors: McEachern Morven G. , Ellahi Basma , Muzahid Khan D. L. 
Published: July 2024

AbstractFood insecurity is acknowledged as a key social determinant of health among older adults. Despite recording significantly higher levels of poverty in comparison to white ethnic groups, older individuals from ethnic minorities are under‐represented as recipients of food aid. Thus, there are knowledge gaps in our understanding of older people and their experiences of food insecurity within ethnic minority communities. Through the theoretical lens of Individual and Community Resilience, we empirically advance our understanding of food security and resilience within South Asian communities via in‐depth interviews with community stakeholders and older individuals from Bangladeshi and Pakistani communities across the Greater Manchester region. Our findings reveal that the integration of temporal, environmental and social constructs within a resilience framework reveals significant potential for further negative social, cultural and economic impact on older ethnic minorities in the future, especially as current food support services do not appear to cater for ethnic dietary preferences, language accessibility and/or cultural norms regarding asking for help/charity outside the home. We predict therefore, in combination with the identified persistent stressors, that food insecurity issues within older ethnic minority communities are likely to get much worse, resulting in the need for extensive resilient capacities to cope with future cost‐of‐living challenges. In acknowledging previous limitations within previous resilience frameworks, we propose an incremental contribution to theory and conclude by identifying culturally and operationally appropriate food support system approaches, which can be used to address the increasing prevalence of “silent poverty” within ethnic minority communities.
Transforming waste to wealth: Impact of food waste‐derived soil amendments and synthetic nitrogen fertilizer on soil dynamics
Authors: O'Connor James , Mickan Bede S. , Gurung Sun K. , Siddique Kadambot H. M. , Leopold Matthias , Bühlmann Christopher H. , Bolan Nanthi S. 
Published: July 2024

AbstractApproximately one‐third of all food produced globally goes to waste, highlighting the need for sustainable waste management technologies like composting and anaerobic digestion. These technologies convert food waste into soil amendment products such as compost, liquid digestate (LD) and solid digestate (SD). However, these food waste‐derived soil amendments have relatively low nutrient contents compared with synthetic nitrogen (N) fertilizers such as urea, making their agricultural use challenging. Despite this, food waste‐derived soil amendments can enhance the physical and biological properties of soil, potentially creating synergistic effects when combined with synthetic N fertilizers. This study aimed to investigate effects of food waste‐derived amendments in soil applied at 50 kg ha−1 total N (compost, LD or SD) and synthetic N fertilizer [urea ammonium nitrate (UAN)] at 50 and 100 kg ha−1 total N. Over 56 days of soil incubation, greenhouse gases (CO2, N2O), soil chemistry (–N, –N, pH) and microbial biomass C (MBC) were measured. Results showed that LD + UAN 50 reduced cumulative N2O emissions by 23% compared with UAN 100, despite having the same total N and similar available N rate applied to soil. Replacing UAN with LD in farming practices can supply equivalent available N while lowering N2O emissions, offering a sustainable nutrient strategy. Moreover, applying food waste‐derived soil amendments can enhance N retention in soils, reducing the need for increased applications of synthetic N fertilizers to compensate for N deficits in farming. Food waste‐derived soil amendments can also act as a slower N release compared with UAN, reducing nitrogen run‐off. SD had the highest CO2 emissions, followed by LD and compost. SD + UAN 50 increased MBC levels because of higher carbon content and labile carbon, and available N because of the application of UAN. The major drawback of using SD compared with LD is that the process of evaporating LD to form SD causes high ammonia volatilization (ammonium in solution into ammonia gas) rates, reducing the available N in SD. Therefore, future studies should explore strategies to reduce ammonia volatilization of LD.
The I in logic
Authors: Russell Gillian 
Published: July 2024

AbstractThis paper argues for the significance of Kaplan's logic LD in two ways: first, by looking at how logic got along before we had LD, and second, by using it to bring out the similarity between David Hume's thesis that one cannot deduce claims about the future on the basis of premises only about the past, and the so‐called "essentiality" of the indexical.
Lexical variation of woods and bush in Ontario English
Authors: Tagliamonte Sali A. , Jankowski Bridget L. 
Published: July 2024

AbstractThis paper examines ongoing lexical variability among words that describe areas with trees, such as woods, bush and forest, among others. The historical perspective shows ongoing semantic evolution of these terms, from wood(s) (c.825) to the emergence of bush in the late 16th century or early 17th century. We assess regional, social and linguistic patterns of variation in 1849 tokens, from individuals born in the late 1800s to early 200s across 21 communities in Ontario, Canada. The most common word is bush; use of woods is moderate while forest is rare. Ancestry and migration play key roles in their distribution, demonstrating that ancestral roots, migration and language contact play into the selection of a word. We argue that lexical variation, when analysed in a comparative sociolinguistic perspective in the context of social typology, history and geographic location, offers important insights into language use and human behaviour.
Thermal Spreading Resistance of Surface Adjacent Localized Heating-Induced Size Effects in Semiconductors
Authors: Abdolhosseinzadeh Amir , Donmezer Nazli 
Published: July 2024

Abstract
Localized heating is encountered in various scenarios, including the operation of transistors, light-emitting diodes, and some thermal spectroscopy techniques. When localized heating occurs on a scale comparable to the mean free path of the dominant energy carriers, additional thermal resistance is observed due to ballistic effects. The main objective of this study is to find a relation between this resistance, problem geometry, and material thermal properties in situations involving localized heating. Models based on the solution of the Fourier heat diffusion equation and the gray phonon Boltzmann Transport Equation are solved simultaneously to calculate the additional thermal resistances that arise from surface adjacent localized heating. Subsequently, the results are analyzed to derive the desired relationship. It is noted that in the context of localized heating resistance, the effects of geometrical variables are nonlinear and substantial, particularly when the Knudsen numbers for the boundary and heat source exceed certain thresholds. Specifically, when the Knudsen number for the surface adjacent heat source exceed 1, localized heating resistance is observed. However, when the Knudsen number based on heat source height and width surpasses 8 and 20, respectively the heat source behaves akin to a point source, no longer significantly affecting the localized heating resistance. At this juncture, the maximum resistance limit is reached.
Methodology to Characterize Row Manifolds for High Power Direct to Chip Liquid Cooling Data Centers
Authors: Shahi Pardeep , Heydari Ali , Eslami Bahareh , Radmard Vahideh , Hinge Chandraprakash , Modi Himanshu , Chinthaparthy Lochan Sai Reddy , Tradat Mohammad , Agonafer Dereje , Rodriguez Jeremy 
Published: July 2024

Abstract
Demand is growing for the dense and high-performing IT computing capacity to support artificial intelligence, deep learning, machine learning, autonomous cars, the Internet of Things, etc. This led to an unprecedented growth in transistor density for high-end CPUs and GPUs, creating thermal design power (TDP) of even more than 700 watts for some of the NVIDIA existing GPUs. Cooling these high TDP chips with air cooling comes with a cost of the higher form factor of servers and noise produced by server fans close to the permissible limit. Direct-to-chip cold plate-based liquid cooling is highly efficient and becoming more reliable as the advancement in technology is taking place. Several components are used in the liquid-cooled data centers for the deployment of cold plate-based direct-to-chip liquid cooling like cooling loops, rack manifolds, CDUs, row manifolds, quick disconnects, flow control valves, etc. Row manifolds used in liquid cooling are used to distribute secondary coolant to the rack manifolds. Characterizing these row manifolds to understand the pressure drops and flow distribution for better data center design and energy efficiency is important. In this paper, the methodology is developed to characterize the row manifolds. Water-based coolant Propylene glycol 25% was used as the coolant for the experiments and experiments were conducted at 21 °C coolant supply temperature. Two, six-port row manifolds' P-Q curves were generated, and the value of supply pressure and the flowrate were measured at each port. The results obtained from the experiments were validated by a technique called flow network modeling (FNM). FNM technique uses the overall flow and thermal characteristics to represent the behavior of individual components.
H
2
inhalation therapy in patients with moderate COVID-19 (H
2
COVID): a prospective ascending-dose phase I clinical trial
Authors: Salomez-Ihl C. , Giai J. , Barbado M. , Paris A. , Touati S. , Alcaraz J. P. , Tanguy S. , Leroy C. , Lehmann A. , Degano B. , Gavard M. , Bedouch P. , Pavese P. , Moreau-Gaudry A. , Roustit M. , Boucher F. , Cinquin P. , Brion J. P. 
Published: July 2024

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has triggered a serious global health crisis, resulting in millions of reported deaths since its initial identification in China in November 2019. The global disparities in immunization access emphasize the urgent need for ongoing research into therapeutic interventions. This study focuses on the potential use of molecular dihydrogen (H2) inhalation as an adjunctive treatment for COVID-19. H2 therapy shows promise in inhibiting intracellular signaling pathways associated with inflammation, particularly when administered early in conjunction with nasal oxygen therapy. This phase I study, characterized by an open-label, prospective, monocentric, and single ascending-dose design, seeks to assess the safety and tolerability of the procedure in individuals with confirmed SARS-CoV-2 infection. Employing a 3 + 3 design, the study includes three exposure durations (target durations): 1 day (D1), 3 days (D2), and 6 days (D3). We concluded that the maximum tolerated duration is at least 3 days. Every patient showed clinical improvement and excellent tolerance to H2 therapy. To the best of our knowledge, this phase I clinical trial is the first to establish the safety of inhaling a mixture of H2 (3.6%) and N2 (96.4%) in hospitalized COVID-19 patients. The original device and method employed ensure the absence of explosion risk. The encouraging outcomes observed in the 12 patients included in the study justify further exploration through larger, controlled clinical trials.

CLINICAL TRIALS

This study is registered with

ClinicalTrials.gov
as
NCT04633980

.
Efficacy of epetraborole against
Mycobacteroides abscessus
in a mouse model of lung infection
Authors: Rimal Binayak , Lippincott Christopher K. , Panthi Chandra M. , Xie Yi , Keepers Tiffany R. , Alley MRK , Lamichhane Gyanu 
Published: July 2024

ABSTRACT

Mycobacteroides abscessus
(
Mab
or
Mycobacterium abscessus
) is a fast-growing mycobacterium that is ubiquitous in the environment and can cause opportunistic disease in people with lung comorbidity and immunodeficiency. There are no Food and Drug Administration-approved drugs for this disease, and repurposed antibiotics have a poor microbiological response. To address the need for effective new antibiotics, we determined the efficacy of epetraborole (EBO) against three
Mab
clinical isolates in a mouse model of lung
Mab
infection. Reduction in lung
Mab
burden over 4 weeks of treatment was the study end point. EBO was administered orally once daily at doses of 25 and 50 mg/kg, which achieved exposures approximating the once-daily dosing of 250 mg and 500 mg, respectively, in humans. EBO administration led to a gradual reduction in the lung
Mab
burden. After 4 weeks of treatment, the efficacies of 25 and 50 mg/kg EBO against isolates ATCC 19977 and M9501 were comparable. However, against isolate M9530, 50 mg/kg EBO was more efficacious than 25 mg/kg and comparable with parenteral imipenem, one of the most efficacious antibiotics against
Mab
. We also undertook a dose-ranging study by evaluating the efficacies of once-daily oral administration of 0.5, 5, 10, 25, and 100 mg/kg EBO against M9501 over 4 weeks. Once-daily oral 100 mg/kg EBO was as effective as twice-daily 100 mg/kg imipenem injection. Our study suggests that EBO could address the unmet need for effective oral treatment options for
Mab
lung disease, given the high rates of
Mab
drug resistance and limited tolerable intravenous options.
Can genomics and meteorology predict outbreaks of legionellosis in urban settings?
Authors: Timms Verlaine J. , Sim Eby , Pey Keenan , Sintchenko Vitali 
Published: July 2024

ABSTRACT

Legionella pneumophila
is ubiquitous and sporadically infects humans causing Legionnaire’s disease (LD). Globally, reported cases of LD have risen fourfold from 2000 to 2014. In 2016, Sydney, Australia was the epicenter of an outbreak caused by
L. pneumophila
serogroup 1 (Lpsg1). Whole-genome sequencing was instrumental in identifying the causal clone which was found in multiple locations across the city. This study examined the epidemiology of Lpsg1 in an urban environment, assessed typing schemes to classify resident clones, and investigated the association between local climate variables and LD outbreaks. Of 223 local Lpsg1 isolates, we identified dominant clones with one clone isolated from patients in high frequency during outbreak investigations. The core genome multi-locus sequence typing scheme was the most reliable in identifying this Lpsg1 clone. While an increase in humidity and rainfall was found to coincide with a rise in LD cases, the incidence of the major
L. pneumophila
outbreak clone did not link to weather phenomena. These findings demonstrated the role of high-resolution typing and weather context assessment in determining source attribution for LD outbreaks in urban settings, particularly when clinical isolates remain scarce.

IMPORTANCE

We investigated the genomic and meteorological influences of infections caused by
Legionella pneumophila
in Sydney, Australia. Our study contributes to a knowledge gap of factors that drive outbreaks of legionellosis compared to sporadic infections in urban settings. In such cases, clinical isolates can be rare, and thus, other data are needed to inform decision-making around control measures. The study revealed that core genome multi-locus sequence typing is a reliable and adaptable technique when investigating Lpsg1 outbreaks. In Sydney, the genomic profile of Lpsg1 was dominated by a single clone, which was linked to numerous community cases over a period of 40 years. Interestingly, the peak in legionellosis cases during Autumn was not associated with this prevalent outbreak clone. Incorporating meteorological data with Lpsg1 genomics can support risk assessment strategies for legionellosis in urban environments, and this approach may be relevant for other densely populated regions globally.
Impact of the interaction between herpes simplex virus 1 ICP22 and FACT on viral gene expression and pathogenesis
Authors: Liu Shaocong , Maruzuru Yuhei , Takeshima Kosuke , Koyanagi Naoto , Kato Akihisa , Kawaguchi Yasushi 
Published: July 2024

ABSTRACT

Facilitates chromatin transcription (FACT) interacts with nucleosomes to promote gene transcription by regulating the dissociation and reassembly of nucleosomes downstream and upstream of RNA polymerase II (Pol II). A previous study reported that herpes simplex virus 1 (HSV-1) regulatory protein ICP22 interacted with FACT and was required for its recruitment to the viral DNA genome in HSV-1-infected cells. However, the biological importance of interactions between ICP22 and FACT in relation to HSV-1 infection is unclear. Here, we mapped the minimal domain of ICP22 required for its efficient interaction with FACT to a cluster of five basic amino acids in ICP22. A recombinant virus harboring alanine substitutions in this identified cluster led to the decreased accumulation of viral mRNAs from UL54, UL38, and UL44 genes, reduced Pol II occupancy of these genes in MRC-5 cells, and impaired HSV-1 virulence in mice following ocular or intracranial infection. Furthermore, the treatment of mice infected with wild-type HSV-1 with CBL0137, a FACT inhibitor currently being investigated in clinical trials, significantly improved the survival rate of mice. These results suggested that the interaction between ICP22 and FACT was required for efficient HSV-1 gene expression and pathogenicity. Therefore, FACT might be a potential therapeutic target for HSV-1 infection.

IMPORTANCE
ICP22 is a well-known regulatory factor of HSV-1 gene expression, but its mechanism(s) are poorly understood. Although the interaction of FACT with ICP22 was reported previously, its significance in HSV-1 infection is unknown. Given that FACT is involved in gene transcription, it is of interest to investigate this interaction as it relates to HSV-1 gene expression. To determine a direct link between the interaction and HSV-1 infection, we mapped a minimal domain of ICP22 required for its efficient interaction with FACT and generated a recombinant virus carrying mutations in the identified domain. Using the recombinant virus, we obtained evidence suggesting that the interaction between ICP22 and FACT promoted Pol II transcription from HSV-1 genes and viral virulence in mice. In addition, CBL0137, an inhibitor of FACT, effectively protected mice from lethal HSV-1 infection, suggesting FACT might be a potential target for the development of novel anti-HSV drugs.
Single-cell transcriptomic analysis reveals the antiangiogenic role of Mgarp in diabetic retinopathy
Authors: Ren Ling , Xia Jiao , Huang Chang , Bai Yun , Yao Jin , Li Dan , Yan Biao 
Published: July 2024

IntroductionDiabetic retinopathy (DR) is a common vascular complication of diabetes mellitus and a leading cause of vision loss worldwide. Endothelial cell (EC) heterogeneity has been observed in the pathogenesis of DR. Elucidating the underlying mechanisms governing EC heterogeneity may provide novel insights into EC-specific therapies for DR.Research design and methodsWe used the single-cell data from the Gene Expression Omnibus database to explore EC heterogeneity between diabetic retinas and non-diabetic retinas and identify the potential genes involved in DR. CCK-8 assays, EdU assays, transwell assays, and tube formation assays were conducted to determine the role of the identified gene in angiogenic effects.ResultsOur analysis identified three distinct EC subpopulations in retinas and revealed that Mitochondria-localized glutamic acid-rich protein (Mgarp) gene is potentially involved in the pathogenesis of DR. Silencing of Mgarp significantly suppressed the proliferation, migration, and tube formation capacities in retinal endothelial cells.ConclusionsThis study not only offers new insights into transcriptomic heterogeneity and pathological alteration of retinal ECs but also holds the promise to pave the way for antiangiogenic therapy by targeting EC-specific gene.