bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trade Liberalization and Performance of Nigeria Economic Growth (1990-2022) an Empirical Study
Authors: Adeoye Peter Ayodeji 
Published: August 2024

Abstract

The association between trade liberalization and economic growth in Nigeria was examined in this study from 1990 to 2022. The study used the Autoregressive Distributed Lag Bounds technique for cointegration. Yearly data were sourced from the World Bank Development Indicator (WDI). This research work considers Gross Domestic Product Per Capita (GDPPC) as the dependent variable, while inflation rate (INF), trade openness (TOPEN), Gross capital formation (GCF), and foreign direct investment (FDI) as the independent variable. Based on the ARDL approach, the test was carried out on each dependent variable and the independent variable to check the long and short-run regression findings for the coefficient of the lagged values of the dependent and independent variables. Some diagnostic test like the serial correlation test, and stability test were also carried out on the variables. From the results obtained Trade openness is positively statistically significant in the short run and the long run. However, the inflation rate is statistically but negatively significant to GDP in the short run and the long run. This means that when there is increased inflation, it reduces the GDPPC growth rate. Based on the findings, it was recommended that The government should set up policies that will encourage trade openness, and trade liberalization to other advanced and developed countries to also develop our own country.
Is mind-mindedness in mothers, fathers and children related to child adaptive and maladaptive emotion regulation?
Authors: Potharst Eva , Broekhorst Myrthe , Colonnesi Cristina , Zeegers Moniek 
Published: August 2024

Abstract

Parental mind-mindedness is an important predictor of child development. It is not clear whether parental mind-mindedness is also related to child emotion regulation in school-aged children or whether child mind-mindedness plays a role. The current study aimed to examine maternal, paternal and children’s mind-mindedness in relation to child emotion regulation and to examine the importance of the valence of mind-related comments (positive, neutral or negative). The study had a cross-sectional design. Mothers, fathers and children from eighty-three families with children aged 8–18 years participated in a mind-mindedness interview, and the children completed a questionnaire measuring adaptive and maladaptive emotion regulation. There was no significant association between maternal or paternal mind-mindedness and children’s mind-mindedness; however, when valence was taken into account, maternal positive and negative mind-mindedness were significantly associated with paternal positive and negative mind-mindedness, respectively. Additionally, children’s mind-mindedness toward their mother and father were significantly associated. Maternal mind-mindedness was the only significant predictor of children’s adaptive and maladaptive emotion regulation: positive and neutral mind-related comments predicted more adaptive emotion regulation, and neutral and negative mind-related comments predicted more maladaptive emotion regulation. Although it appears possible to reliably measure children’s mind-mindedness, the question remains regarding the meaningfulness of measuring this concept in childhood. The results of the current study suggest that, in school-aged children, mothers’ representational mind-mindedness plays a more significant role in the development of adaptive and maladaptive emotion regulation than fathers’ representational mind-mindedness. The valence of mind-related comments seems to matter. However, additional research is needed to determine the directionality of these effects.
Antimicrobial resistance characterization of Enterococcus faecium, Enterococcus faecalis and Enterococcus hirae isolated from marine coastal recreational waters in the State of São Paulo, Brazil
Authors: Santiago Giovanna Silva , Dropa Milena , Martone-Rocha Solange , dos Santos Talita Pereira , de Moura Gomes Vasco Tulio , Barbosa Mikaela Renata Funada , Razzolini Maria Tereza Pepe 
Published: August 2024

ABSTRACT
Coastal water quality is facing increasing threats due to human activities. Their contamination by sewage discharges poses significant risks to the environment and public health. We aimed to investigate the presence of antibiotic-resistant Enterococcus in beach waters. Over a 10-month period, samples were collected from four beaches in the State of São Paulo (Brazil). Enterococcus isolates underwent matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) and molecular analysis for accurate genus and species identification. The antimicrobial susceptibility for 14 antibiotics was evaluated using the disc diffusion method followed by a multidrug-resistance (MDR) classification. PCR amplification method was used to detect antimicrobial resistance genes (ARGs). Our findings revealed the prevalence of Enterococcus faecalis, E. faecium and E. hirae. Out of 130 isolates, 118 were resistant to multiple antibiotics. The detection of resistance genes provided evidence of the potential transfer of antibiotic resistance within the environment. Our findings underscore the necessity for continuous research and surveillance to enhance understanding of the pathogenicity and antimicrobial resistance mechanisms of Enterococcus, which is crucial to implement effective measures to preserve the integrity of coastal ecosystems.
Mitochondrial Deoxyguanosine Kinase Induces 5-Fluorouracil Chemotherapy Sensitivity through Autophagy
Authors: Dong Lu , Liu Sifan , Sun Wenjing , Liu Siying , Zhang Nan , Zhang Shutian 
Published: August 2024

Aims:
The purpose of this study was to investigate the role of DGUOK in the pro-gression of colorectal cancer (CRC) and its impact on the sensitivity of CRC cells to 5-FU treatment.

Methods:
We conducted bioinformatics analysis and qRT-PCR to evaluate DGUOK expression in CRC tissues/cells. Cell viability of CRC cells treated with 5-FU was assessed using CCK-8 and colony formation assays. Autophagy levels were determined through immunofluorescence assays and Western blot analysis. Additionally, the influence of p-p38 on autophagy was inves-tigated via Western blotting. A rescue assay was performed to confirm whether DGUOK/p38 affects 5-FU sensitivity in CRC cells through autophagy.

Results:
Our findings indicate that DGUOK is upregulated in CRC tissues compared to normal tissues, correlating with increased cell proliferation and migration. Functionally, inhibition of DGUOK enhances autophagy, thereby decreasing the sensitivity of CRC cells to 5-FU. This ef-fect is partly mediated by DGUOK's impact on the mitogen-activated protein kinase (MAPK) pathway, specifically promoting the phosphorylation of p38 MAPK, a crucial regulator in au-tophagy pathways.

Conclusion:
These results suggest that DGUOK could serve as a novel marker for predicting the efficacy of 5-FU in CRC treatment.
A Comprehensive Review on the Importance of Approaches for the Identification of Potential Biological Targets in Cancer Therapy
Authors: Kuruvalli Gouthami , Maity Subhasish , Santra Ayantika , Venkatesh Guru Prasad , swamy A. M. M. Mallikarjuna , Mubeena Ameerjan , Hebbani Ananda Vardhan , Reddy Vaddi Damodara 
Published: August 2024

Abstract:
Cancer is the uninhibited proliferation of aberrant body cells. Cancer treatments and disorders
might have adverse implications. Side effects occur when medication affects healthy organs
or tissues. Identifying potential biological targets in cancer treatment is a tough and diverse
process that requires consideration of the underlying molecular mechanisms that drive cancer
growth and development. Drug identification methods are mostly based on in vitro drug screening
and in vivo animal studies. The biologically-based therapy technique has also been successfully
utilized to identify anti-cancer medications, as evidenced by studies and investigations based on a
biological target-protein interaction, drug-target relationship, and disease-gene network. To identify
biological targets, the researchers have looked for specific genetic alterations that aid in tumor
development and growth. This review focuses on the biological targets' role in cancer disease and
the usefulness of in silico studies to understand the target protein-drug interaction and predict therapeutic
drug molecules for cancer treatment.
Antidiabetic Potentials of Catechin in Combination with Metformin: An In Vitro And Molecular Docking Study
Authors: Rani Dash Jyoshna , Pattnaik Gurudutta , Pattanaik Sovan , Ghosh Goutam , Rath Goutam , Kar Biswakanth 
Published: August 2024

Objective:
This work aims to evaluate the combined anti-diabetic effects of metformin
and catechin in vitro and in silico.

Methods:
In vitro, anti-diabetic potentials of (α-amylase and α-glucosidase) catechin, metformin,
and a combination of catechin and metformin were studied at different concentrations using acarbose
as standard. An in silico study determined their binding interactions with α-amylase (PDB
ID: 1hvx) and α-glucosidase (PDB ID: 5zcb). The molecular docking study further revealed the
binding energy and interacting residues of the docked 3D structure of the catechin, metformin,
and acarbose as a standard with the α-amylase and α-glucosidase receptors.

Results:
The result showed that a 100 μg/ml dosage of metformin and catechin demonstrated
higher enzyme inhibition compared to the separate treatments. Compared to metformin and acarbose,
the results of this study showed that catechin with 1hvx and 5zcb exhibited the highest
binding affinity interaction via hydrogen bonding and pi-interaction.

Conclusion:
The study's findings showed that when compared to metformin and acarbose,
catechin with 1hvx and 5zcb showed the highest binding affinity relationship via hydrogen
bonding and pi-interaction. Higher levels of enzyme inhibition were seen when metformin and
catechin were administered together than when either medication was taken alone. Based on the
aforementioned report, we deduced that metformin and catechin together had more potent antidiabetic
actions in vitro. We can conclude that catechin, in combination with metformin, may be
developed into a possible oral hypoglycemic drug. High-affinity capacity catechin was found to
have a strong inhibitory effect on α-glucosidase and α-amylase. The possible interaction
pathways between these main inhibitors and two digestive enzymes were identified by docking
studies. This study demonstrates the efficaciousness of catechin in preventing and treating posthyperglycemia.
This work suggests interesting directions for future research and clinical
applications by endorsing the use of these phytocompounds as powerful anti-diabetic
pharmaceuticals, either as single compounds or in combination with synthetic drugs.
Microwave-Assisted Fabrication of α-AL2O3@ZIF-8 Composite for Effective Removal of Methylene Blue: Kinetic and Isothermal Studies
Authors: Huynh Thao Thi Thu , Dam Vu Nguyen , Perng Yuan-Shing , Nguyen Thi-Truc-Mai , Vu Thuy Thi 
Published: August 2024

Background:
Synthetic dye removal from wastewater poses significant environmental
challenges. Metal-organic Frameworks (MOFs), like ZIF-8, offer potential solutions due to their
high adsorption capacities. This study has investigated the efficacy of a novel composite material,
α-Al2O3@ZIF-8, for Methylene Blue (MB) removal.

Objective:
This study aimed to assess the feasibility of α-Al2O3@ZIF-8 for MB removal. The
synthesis via microwave-assisted methods, physicochemical characterization, adsorption efficiency
evaluation, and isothermal/kinetic modeling, has been conducted.

Methods:
The α-Al2O3@ZIF-8 composite was synthesized and characterized using SEM, TEM,
FTIR, and BET techniques. The adsorption efficiency for MB was tested, and isothermal/kinetic
models were applied for mechanistic understanding.

Results:
The composite exhibited robust crystal connections and uniform distribution, with particle
sizes ranging from 0.5 to 0.6 μm. MB adsorption efficiency exceeded 97.8% under optimal
conditions. Isothermal and kinetic modeling revealed favorable adsorption behavior, notably with
the Langmuir and pseudo-second-order models.

Conclusion:
Microwave-synthesized α-Al2O3@ZIF-8 shows promise for efficient MB removal,
with treatment efficiencies surpassing 97%. This underscores the potential of MOFs in
wastewater treatment and emphasizes the importance of understanding adsorption mechanisms
for optimization.
Analisis Kompetensi Kepribadian Mahasiswa Calon Guru SD FKIP Universitas Riau
Authors: Pitaloka Widuri Bebby , Hermita Neni , Alim Jesi Alexander , Fauza Naila , Dipuja Diah Anugrah , Wijaya Tommy Tanu 
Published: August 2024

This study aims to describe in detail how the personality competencies of primary education teacher candidates for SD FKIP, Riau University. This research uses a quantitative approach with a survey method. The research was conducted at PGSD FKIP, Riau University, involving 120 active students. The data collection technique in this study used a questionnaire. The data analysis technique used in this study is to calculate the percentage of data from each indicator, then interpret the data percentage score and analyze each indicator in depth. The results of this study indicate that the personality competencies of primary school education teacher candidates 70,10% with a good category. This research is expected to be an evaluation of various parties in the personality of primary school education teacher candidates at FKIP, Riau University. This research is also expected to be a study material for other researchers in analyzing and developing student personality competencies in preparation for becoming primary school education teacher candidates. Keywords: Personality competence, survey, pre-service elementary school teacher ========================================================================================================Penelitian ini bertujuan untuk mendeskripsikan secara detail bagaimana kompetensi kepribadian mahasiswa calon guru SD FKIP Universitas Riau. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survey. Penelitian dilakukan di PGSD FKIP Universitas Riau dengan melibatkan 120 mahasiswa aktif. Teknik pengumpulan data pada penelitian ini menggunakan kuesioner. Adapun teknik analisis data yang digunakan dalam penelitian ini adalah menghitung persentase data dari setiap indikator, kemudian menginterpretasi skor persentase data dan menganalisis setiap indikatornya secara mendalam. Hasil penelitian ini menunjukkan bahwa kompetensi kepribadian mahasiswa calon guru SD 70,10% dengan kategori baik. Penelitian ini diharapkan dapat menjadi evaluasi berbagai pihak dalam kepribadian mahasiswa calon guru SD di FKIP Universitas Riau, penelitian ini juga diharapkan dapat menjadi bahan kajian bagi peneliti lain dalam menganalisis dan mengembangkan kompetensi kepribadian mahasiswa dalam persiapan menjadi calon guru SD. Kata kunci: kompetensi kepribadian, survei, mahasiswa calon guru SD
Penggunaan Modul “Aksi Sekolah” sebagai Upaya Peningkatan Kemampuan Literasi Baca Tulis Peserta Didik SD
Authors: Utami Putri Rizki , Kironoratri Lintang , Fardani Much Arsyad 
Published: August 2024

Literasi baca tulis merupakan salah satu literasi dasar yang harus dikuasai peserta didik berdasarkan Gerakan Literasi Nasional (GLN) yang dicanangkan oleh Kemendikbud. Berdasarkan hasil skor AKSI / INAP tahun 2016 capaian kemapuan membaca peserta didik jenjang sekolah dasar menunjukkan hasil yang memprihatinkan, yaitu 46,83 % peserta didik memiliki kemampuan membaca dengan kategori kurang. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh penggunaan modul “Aksi Sekolah” dalam upaya untuk meningkatkan literasi baca tulis peserta didik. Jenis penelitian yaitu, kuantitatif eksperimen dengan desain one group pretest posttest design. Subjek penelitian yaitu peserta didik kelas IV SDN 1 Cepu. Teknik pengumpulan data meliputi teknik observasi, tes, wawancara dan dokumentasi. Analisis data menggunakan uji V Aiken untuk instrument dan uji N-gain untuk uji data. Hasil rata-rata nilai pretest adalah 61.60 sedangkan nilai posttest adalah 79.20. Hasil analisis hipotesis menggunakan Uji N Gain diperoleh rata–rata N-gain skor sebesar 0,57 termasuk dalam kategori sedang. Dapat disimpulkan penggunaan modul “Aksi Sekolah” membawa pengaruh nyata dan dapat meningkatkan literasi baca tulis peserta didik SDN 1 Cepu dengan kategori sedang.
Penyesuaian Gaya Belajar dengan Prinsip aliran Humanisme Berbasis Media PhET Kelas 6 SDN Telang 1
Authors: Rodhiah Rizky , A'yun Dya 
Published: August 2024

This article explains an approach to adapting learning styles based on humanistic principles using PhET simulation media. Humanism in education emphasizes the development of individual potential and emphasizes meaningful learning experiences. PhET Simulations, on the other hand, are online learning resources that provide interactive simulations for understanding scientific and mathematical concepts. The humanistic educational approach views students as unique individuals with different learning needs. Therefore, adapting learning styles is the key to achieving learning effectiveness. PhET Simulation Media allows students to learn through virtual experiments and conceptualize abstract ideas practically. This article examines various learning styles that can be identified through a humanistic approach, including visual, auditory, and kinesthetic learning styles. Each learning style has its preferences regarding understanding and retaining information. PhET simulation provides the right solution to accommodate these different learning styles by presenting learning material through visualization, audio, and kinesthetics. In this context, this article also presents research findings and case studies that show how the implementation of PhET simulations succeeded in improving the understanding of certain concepts for students with certain learning styles. The results of this research provide practical insights for educators to identify student learning styles and incorporate the use of PhET simulations into everyday learning. Educators can create learning environments that support students' holistic growth by integrating humanism, learning style adaptation, and interactive simulation technologies such as PhET. This article invites readers to consider the importance of incorporating humanistic principles into learning design to provide meaningful and relevant learning experiences for all students. Keywords: Learning Style, Humanism, Simulation Media
KESUSASTRAAN: AJARAN NILAI-NILAI MORAL MASA HAMENGKUBUWONO V
Authors: Putri Gandes Sekar 
Published: August 2024

Kajian mengenai nilai-nilai kepemimpinan Hamengkubuwono V dapat ditemukan pada karya-karya sastra yang berkembang pada masa itu. Karya sastra pada masa Hemangkubuwono V berkembang pesat dan mengandung ajaran-ajaran moral yang dapat menjadi acuan pada zaman sekarang. Salah satu karya sastra yang berkembang, yaitu Serat Jatipusaka Makutharaja yang berisi keteladanan seorang pemimpin dalam bertindak, nilai-nilai kepemimpinan sebagai bentuk keteladanan dan nilai-nilai kepemimpinan yang diimplementasikan dalam kehidupan. Kajian nilai kepemimpinan pada karya sastra dalam tulisan ini dapat disebut sebagai model kepemimpinan Jawa-Islam. Kata kunci: karya sastra, nilai-nilai moral, Hamengkubuwono V
CEMME PASSILI' DI DESA ULO KABUPATEN BONE
Authors: Hikmah Nurhikmah 
Published: August 2024

AbstrakArtikel ini bertujuan untuk menggambarkan Sejarah dan eksitensi tradisi cemme passili’, prosesi tradisi cemme passili’, di Dusun Ulo-ulo Desa Ulo. Jenis penelitian yang digunakan adalah Deskriptif Kualitatif. Teknik pengumpulan data yang dipakai yaitu, wawancara. Penelitian ini menemukan bahwa sejarah awal tradisi cemme passili’ disebabkan musim kemarau yang panjang sehingga membuat keadaan desa pada waktu itu gagal total dalam bidang pertanian. Kejadian tersebut berlangsung sekitar kurang lebih satu tahun, kekeringan dimana-mana semua tumbuhan kering dan mati, sumber air tidak ada. pada waktu itu seseorang menyuruh masyarakat desa untuk melakukan sebuah ritual mandi-mandi di sebuah sumber air diatas gunung. Banyaknya masyarakat dari luar yang datang menyaksikan tradisi ini sehingga keakraban, silaturahmi antara masyarakat terjalin, jadi tak heran masyarakat Ulo-ulo memotong kuda untuk menjamu para tamu yang datang berkunjung. Tradisi ini juga membuat masyarakat tetap mempertahankan tradisi ini masih tetap eksis sampai sekarang. Tradisi cemme passili’ bisa dijadikan warisan budaya bagi daerah Kabupaten Bone terkhususnya bagi masyarakat di Desa Ulo Dusun Ulo-ulo. Tradisi cemme passili’ juga bisa dijadikan obyek wisata yang bisa menarik banyak pengunjung dari luar. Kata kunci: Adat, Cemme Passili’, Masyarakat
Value of Value based Education!
Authors: Mehta Kunal 
Published: August 2024

The paper in question aims to study the meaning of the oft quoted and over exploited term ‘Value- based Education’ . The other aim of this appear is to understand how value -based education can bring a dramatic transformation in the life of an individual and how at the same time it can introduce constructive changes in society. To seek answers to these questions, the paper studies the ancient system of education besides making an honest assessment of the modern system of education . The paper concludes that no’ Education System’ on this planet can succeed in its mission if it delivers lessons sans ethics and values.
PENDUDUKAN OKINAWA: ANALISIS HUBUNGAN JEPANG DAN AMERIKA SERIKAT PASCA PERANG DUNIA II TAHUN 1945
Authors: Triyanto Jefri Rieski 
Published: August 2024

Penelitian ini bertujuan untuk: (1) Menjelaskan awal mula pendudukan Amerika Serikat di wilayah Okinawa (2) Menganalisis dinamika hubungan Jepang dan Amerika Serikat pasca Perang Dunia II Tahun 1945. Penelitian ini menggunakan metode penelitian sejarah yang terdiri dari heuristik, kritik (intern dan ekstern), interpretasi, dan historiografi. Hasil dari penelitian ini menunjukkan bahwa (1) Latar belakang pendudukan Okinawa oleh Amerika Serikat tidak terlepas dari terjadinya Perang Dingin. Okinawa menjadi benteng dan kapal induk Amerika Serikat untuk membendung paham komunis di Asia Timur (2) Pendudukan Okinawa oleh Amerika Serikat dimulai sejak Deklarasi Postdam yang menandai penyerahan tanpa syarat Jepanng kepada Sekutu. Dinamika hubungan Jepang dan Amerika Serikat kemudian dilanjutkan dengan Perjanjian San Fransisco, Perjanjian Bilateral keamanan Japan-US Security Treaty, Treaty of Mutual Cooperation and Security between the United States Of America and Japan, dan pada akhirnya melalui proses diplomasi yang Panjang Okinawa resmi dikembalikan kepada pemerintah Jepang pada tahun 1972