bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preprocedural statin therapy, inflammation, and myocardial injury in low‐risk stable coronary artery disease patients submitted to coronary stent implantation
Authors: Greque Gilmar V. , Serrano Carlos V. , Strunz Célia M. , Soeiro Alexandre , Santos Márcio , Pivateli Flávio , Jacob José Luis B. , Pesaro Antonio Eduardo P. , Nicolau José Carlos , Kalil‐Filho Roberto 
Published: April 2013

ObjectiveEvaluate if statin therapy prior to elective coronary stent implantation (CSI) reduces the plasma levels of markers of inflammation and of myocardial necrosis in low‐risk stable coronary artery disease patients (CAD).BackgroundThe elevation of markers of inflammation and of myocardial necrosis after percutaneous coronary intervention may interfere with clinical outcome. Among acute coronary syndrome patients, statins improve clinical outcomes when used before CSI—mostly due to reduction of CSI‐related myocardial infarction. However, little is known concerning preprocedural statin therapy on the reduction of these markers in stable patients at low‐risk.MethodsIn this prospective, observational study, 100 patients (n = 50 on statin therapy vs. n = 50 not on statin) with stable coronary artery disease underwent elective CSI. Inflammatory (C‐reactive protein [CRP], interleukin [IL]‐6, tumor necrosis factor‐α and matrix metalloproteinase‐9) and myocardial necrosis markers (troponin I and CK‐MB) were determined before and 24 hr after CSI.ResultsAll patients presented a significant increase of CRP and IL‐6 after CSI. However, this increase was attenuated in patients on statin therapy prior to CSI than those without statin therapy: 75% vs. 150% (P < 0.001) and 192% vs. 300% (P < 0.01). The other pro‐inflammatory markers were similar for both sets of patients. Troponin I and CK‐MB did not change after CSI regardless of previous statin therapy or not.ConclusionsPretreatment with statin attenuates procedural inflammation, denoted by markedly lower increases of CRP and IL‐6 levels, in elective CSI within low‐risk stable CAD patients. Periprocedural myocardial injury was irrelevant and was not affected by preprocedural statin therapy in this population. © 2015 Wiley Periodicals, Inc.
Late and very late coronary stent thrombosis: Intravascular ultrasound findings and associations with antiplatelet therapy
Authors: Pesarini Gabriele , Dandale Rajesh , Rigamonti Antonio , Pighi Michele , Zivelonghi Carlo , Mugnolo Antonio , Ferrero Valeria , Vassanelli Corrado , Ribichini Flavio 
Published: April 2013

Background and ObjectiveLate and very‐late stent occlusion remains a serious complication of coronary stenting. Despite their high anti‐restenotic efficacy, drug‐eluting stents (DES) have been associated to more late‐thrombosis as compared to bare‐metal stents (BMS). The aim of this study is to analyze the clinical presentation, angiographic, and intravascular ultrasound (IVUS) findings in patients with late or very late stent thrombosis and the relationship with the antiplatelet regimen.Methods and ResultsBetween January 2007 and December 2011, 34 consecutive patients with clinical syndromes compatible with late or very‐late stent occlusion were studied with IVUS during emergency catheterization; 25 had DES and 9 had BMS. Thrombotic total occlusion was more common in DES (16 = 64%) than BMS patients (2 = 22%; P = 0.02) and ST‐segment elevation myocardial infarction was the predominant clinical presentation in the former group (60% compared to 22%; P = 0.05). The time elapsed between implantation and failure was much longer in DES patients: 33 ± 22 versus 17 ± 14 months for BMS; P = 0.05. IVUS analysis showed a higher incidence of incomplete stent apposition (ISA) in the DES group compared to the BMS group (56% vs. 11%; P = 0.005) and in‐stent plaque rupture was the most common finding in the BMS group (78%). In DES group, ISA was found more frequently in patients still under dual antiplatelet therapy (71%).ConclusionsVery late DES failure often causes ST‐elevation myocardial infarction; these very late events may not correlate with the interruption of antiplatelet therapy. Severe, late acquired ISA belongs to DES and is frequently observed in patients with very late DES thrombosis. © 2013 Wiley Periodicals, Inc.
Magnetic positioning system in coronary angiography and percutaneous intervention
Authors: Weisz Giora , Smilowitz Nathaniel R. , Moses Jeffrey W. , Rabbani LeRoy E. , Collins Michael B. , Herscovici Adrian , Jeron Andreas , Leon Martin B. , Luchner Andreas 
Published: April 2013

ObjectivesThis study sought to evaluate the safety and feasibility of a magnetic medical positioning system (MPS) to determine the three‐dimensional (3D) position and orientation of intracoronary wires and catheters and to guide angiography and percutaneous coronary intervention (PCI).BackgroundCoronary angiography relies on fluoroscopy for catheter navigation and often fails to accurately portray vessel tortuosity, overlap, and length because of complex anatomy and foreshortening of curved coronary segments.MethodsForty adult participants underwent coronary angiography and/or PCI with MPS guidance. Two interventional cardiologists independently scored (1–5) the accuracy of MPS catheter tracking projected on live fluoroscopy, recorded cine loops, and 3D vessel reconstructions. Measurements from MPS reconstructions were compared to conventional two‐dimensional (2D) quantitative coronary angiography (QCA) measurements. Device procedural success was defined as the ability of the MPS‐enabled catheter to reach the target vessel, perform the intended operations, and be retrieved without major adverse cardiac events.ResultsDiagnostic coronary angiography was performed in 19 (47.5%) and PCI in 21 patients (52.5%). MPS procedural success was achieved in 36 (90%) of the cases. MPS accuracy was highest with the MPS superimposed on live fluoroscopy (4.9 ± 0.2/5) and the 3D vessel reconstruction (4.7 ± 0.5/5). MPS length measurements were more accurate than conventional QCA.ConclusionsThis study demonstrates the feasibility and safety of magnetic catheter tracking with 3D positional data during diagnostic angiography and PCI. Catheter position was accurately projected on real‐time fluoroscopy, recorded cine loops, and 3D reconstructions. An MPS may serve as a platform for device navigation and positioning during PCI. © 2013 Wiley Periodicals, Inc.
Acute outcome of stent therapy for coarctation of the aorta: Results of the coarctation of the aorta stent trial
Authors: Ringel Richard E. , Vincent Julie , Jenkins Kathy J. , Gauvreau Kimberlee , Moses Heidi , Lofgren Kimberly , Usmani Kudret 
Published: April 2013

ObjectivesThe coarctation of the aorta stent trial (COAST) is a pivotal trial of the NuMED Cheatham Platinum Stent® for treatment of coarctation of the aorta (CoA).BackgroundCoA is a congenital obstruction to flow through the aorta. Stents have been used since the 1990s to treat CoA; none have been approved by the Food and Drug Administration for this indication.MethodsIn a prospective, multicenter study 105 patients received stents for treatment of CoA. Data was collected in the catheterization laboratory, on discharge and at 1‐month postprocedure.ResultsOf 105 patients, 69% were male; 57% had native CoA. Noninvasive, baseline systolic blood pressure (SBP) showed upper extremity (UE) SBP to be 140 ± 16 mm Hg and UE to lower extremity (LE) SBP difference 29 ± 17 mm Hg. At catheterization, baseline ratio of minimum CoA diameter to diameter of descending aorta (CoA:DAo) was 0.46 ± 0.16. Implants (104/105) were successful with one stent migration. There were no deaths or serious complications. Paradoxical hypertension occurred in 6%. Four percent of patients experienced somewhat serious adverse events related to the procedure. All patients achieved relief of ascending aorta to Dao pressure gradient: mean = 2.0 ± 4.0 mm Hg (P < 0.001). The CoA:DAo increased to 0.84 ± 0.18. At 1‐month, UE SBP was 120 ± 12 mm Hg, UE to LE SBP difference = −1 ± 12 mm Hg. Ninety‐nine percent of patients had UE to LE SBP difference <20 mm Hg.ConclusionsStenting of CoA, using the NuMED Cheatham Platinum Stent, is acutely safe and effective for treatment of CoA. © 2013 Wiley Periodicals, Inc.
Balloon‐assisted tracking: A must‐know technique to overcome difficult anatomy during transradial approach
Authors: Patel Tejas , Shah Sanjay , Pancholy Samir , Rao Sunil , Bertrand Olivier F. , Kwan Tak 
Published: April 2013

ObjectiveTo examine the use and outcomes of balloon‐assisted tracking (BAT) technique for dealing with complexities of arm and chest vasculature during transradial approach (TRA) at a single high volume radial center.BackgroundTRA has been used for coronary angiography and percutaneous coronary interventions (PCI) around the world. Different techniques have been described to address the anatomical issues and tortuosities for successful completion of coronary angiography and PCI. This study describes the use of BAT technique and associated outcomes during real world clinical practice.MethodsSubjects comprised 63 patients, (out of total 8,245 patients between January 2011 and December 2012) in whom we encountered significantly complex anatomical course in radial, brachial, or subclavian region, leading to difficult advancement of a diagnostic or a guide catheter despite trying all standard maneuvers. In all of them BAT technique was used and they were retrospectively analyzed for the purpose of this study.ResultsAbout 63 (0.76%) of 8,245 patients met the study criteria. Twenty‐five (39.7%) patients had very small RA. Twenty‐two (34.9%) had severe RA tortuosity. Four (6.3%) had complex RA loops. Six (9.5%) had severe RA spasm and six (9.5%) had severe subclavian tortuosity and/or stenosis. We encountered technical failure in three (4.8%) patients (two had very small RA and one had 360 degree RA loop).ConclusionBAT technique was useful to address the anatomical issues and tortuosities of radial, brachial, and subclavian vasculature during TRA. © 2013 Wiley Periodicals, Inc.
Gd2Ti2O7/In2O3: Efficient Visible‐Light‐Driven Heterojunction‐Based Composite Photocatalysts for Hydrogen Production
Authors: Nashim Amtul , Martha Satyabadi , Parida K. M. 
Published: April 2013

AbstractA series of Gd2Ti2O7/In2O3heterojunction‐based composite photocatalysts was prepared by using solid‐state reaction methods and their activity was evaluated by measuring the photocatalytic H2production under visible light (λ≥400 nm). The materials were characterised by using XRD, diffuse reflectance UV (DRUV)/Vis spectroscopy, TEM, field emission SEM (FESEM), photoluminescence (PL) spectroscopy, X‐ray photoelectron spectroscopy (XPS), and BET surface area and photocurrent measurements. The modification of Gd2Ti2O7with In2O3resulted in a remarkable enhancement of the activity for H2production with respect to the single components under visible light. The photocurrent and Mulliken electronegativity results show that Gd2Ti2O7and In2O3have a well‐matched band potential to exhibit synergic effects. The enhanced activity may be ascribed to the light absorption properties and the reduction of the recombination of charge carriers at the composite interface. The catalyst Gd2Ti2O7/In2O3with 60 at % In (60 IGTO) showed the highest activity in comparison to the other composite materials prepared.
Binuclear Cooperative Catalysts for the Hydrogenation and Hydroformylation of Olefins
Authors: Hetterscheid Dennis G. H. , Chikkali Samir H. , de Bruin Bas , Reek Joost N. H. 
Published: April 2013

AbstractCooperative activation of substrates simultaneously by a (transition) metal and a protein residue is a common strategy in enzyme catalysis. Cooperative dinuclear catalysis for synthetic systems is relatively underdeveloped. Here, we focus on some examples of dinuclear hydrogenation and hydroformylation reactions, with the aim to stimulate the scientific community to develop more catalytic processes based on cooperative dinuclear systems.
Versatile Probes for the Selective Detection of Vicinal‐Dithiol‐Containing Proteins: Design, Synthesis, and Application in Living Cells
Authors: Huang Chusen , Yin Qin , Meng Jiangjiang , Zhu Weiping , Yang Yi , Qian Xuhong , Xu Yufang 
Published: April 2013

AbstractEndogenous vicinal‐dithiol‐containing proteins (VDPs) that have two thiol groups close to each other in space play a significant importance in maintaining the cellular redox microenvironment. Approaches to identify VDPs mainly rely on monitoring the different concentration of monothiol and total thiol groups or on indirect labeling of vicinal thiols by using p‐aminophenylarsenoxide (PAO). Our previous work has reported the direct labeling of VDPs with a highly selective receptor PAO analogue, which could realize fluorescence detection of VDPs directly in living cells. Herein, we developed a conjugated approach to expand detectable tags to nitrobenzoxadiazole (NBD), fluorescein, naphthalimide, and biotin for the synthesis of a series of probes. Different linkers have also been introduced toward conjugation of VTA2 with these functional tags. These synthesized flexible probes with various features will offer new tools for the potential identification and visualization of vicinal dithiols existing in different regions of VDPs in living cells. These probes are convenient tools for proteomics studies of various disease‐related VDPs and for the discovery of new drug targets.
Analyzing the Vibrational Signatures of Thiophenol Adsorbed on Small Gold Clusters by DFT Calculations
Authors: Tetsassi Feugmo Conrard Giresse , Liégeois Vincent 
Published: April 2013

AbstractUsing density functional theory, we calculate the IR and Raman signatures of the thiophenol (TP) molecule adsorbed on gold clusters by mimicking the different types of adsorption sites, and we analyze these signatures by using advanced tools implemented into the pyvib2 program. First, we follow the evolution of the vibrational normal modes from the isolated TP molecule to those of TP adsorbed on different clusters to highlight the influence of the site of adsorption on the vibrational motions. The use of the overlap matrix between the modes enables mode permutations, mode mixings, and mode splittings to be highlighted, all of which depend not only on the adsorption but also on the type of cluster and its symmetry. Second, the IR and Raman signatures were analyzed by using group coupling matrices and atomic contribution patterns based on the Hug decomposition scheme. Key results include 1) the fact that Raman spectroscopy is more sensitive than IR spectroscopy with respect to the nature of the coordination site, 2) an IR criterion that distinguishes between on‐top coordination (onefold coordinated) with respect to the bridge (twofold coordinated) and hexagonal close‐packed hollow site coordination (threefold coordinated), and 3) the best agreement to the experimental Raman spectrum with regard to signatures in the 500 to 1200 cm−1 region is obtained for bridged, twofold coordination.
Nickel Phosphite Superstructures Assembled by Nanotubes: Original Application for Effective Electrode Materials of Supercapacitors
Authors: Pang Huan , Wei Chengzhen , Ma Yahui , Zhao Shanshan , Li Guochang , Zhang Jiangshan , Chen Jing , Li Sujuan 
Published: April 2013

AbstractNickel phosphite (Ni11(HPO3)8(OH)6) superstructures assembled by nanotubes are synthesized under mild hydrothermal conditions with the sodium salt of polystyrene sulfonic acid. More importantly, Ni11(HPO3)8(OH)6 superstructures are applied as electrode materials for supercapacitors. Benefitting from their novel superstructures, in a three‐electrode system, Ni11(HPO3)8(OH)6 superstructure electrodes show a good specific capacitance (1876 F g−1 at 0.625 A g−1), good rate capability, and excellent cycling properties (95 % of the initial specific capacitance at 6.25 A g−1 after 2000 cycles) in 3.0 M KOH. Additionally, asymmetric Ni11(HPO3)8(OH)6–graphene nanosheet supercapacitors are also designed. The specific energy of a cell in 3.0 M KOH reaches about 28.6 Wh kg−1 at 92.5 W kg−1.
Experimental and Theoretical Studies on the Controlled Synthesis of Alkali‐Metal‐Doped Rare‐Earth Oxysulfide Nanocrystals
Authors: Zhang Tao , Gu Jun , Ding Yi , Zhang Ya‐Wen , Yan Chun‐Hua 
Published: April 2013

AbstractAlkali‐metal (Li, Na, K)‐doped lanthanum oxysulfide nanoplates were obtained in the hexagonal phase by thermolysis of metal acetylacetonates in organic solvents with high boiling points and sulfurization using sulfur powders. The characterization results showed that the size, shape, crystallinity, composition, and phase stability of the La2O2S nanocrystals were affected by the doped alkali metals. Combined with first‐principles calculations of the formation energy of anionic defects in the lattices, the ternary phase diagrams for the formation of rare‐earth oxysulfides (RE2O2S) were calculated. Both the experimental results and the phase diagrams have demonstrated that the doped alkali metals are capable of promoting the formation of RE2O2S nanocrystals in the order of K≈Na>Li. With K acting as the doping alkali metal, the phase‐formation capability for different RE2O2S (e.g., Eu, Gd, Yb, Lu) along the lanthanide series was also explored under the guidance of the hard and soft acid and base (HSAB) theory. Moreover, the as‐developed synthetic route could be applied also to the production of K/Eu‐ and K/Tb‐codoped La2O2S nanoplates, which displayed intense red and green emissions, respectively, under ultraviolet‐light excitations.
Compressive sensing for ultra‐wideband channel estimation: on the sparsity assumption of ultra‐wideband channels
Authors: Başaran Mehmet , Erküçük Serhat , Çırpan Hakan Ali 
Published: April 2013

SUMMARYDue to the sparse structure of ultra‐wideband (UWB) multipath channels, there has been a considerable amount of interest in applying the compressive sensing (CS) theory to UWB channel estimation. The main consideration of the related studies is to propose different implementations of the CS theory for the estimation of UWB channels, which are assumed to be sparse. In this study, we investigate the suitability of standardized UWB channel models to be used with the CS theory. In other words, we question the sparsity assumption of realistic UWB multipath channels. For that, we particularly investigate the effects of IEEE 802.15.4a UWB channel models and the selection of channel resolution both on channel estimation and system performances from a practical implementation point of view. In addition, we compare the channel estimation performance with the Cramer‐Rao lower bound for various channel models and number of measurements. The study shows that although UWB channel models for residential environments (e.g., channel models CM1 and CM2) exhibit a sparse structure yielding a reasonable channel estimation performance, channel models for industrial environments (e.g., CM8) may not be treated as having a sparse structure due to multipaths arriving densely. Furthermore, it is shown that the sparsity increased by channel resolution can improve the channel estimation performance significantly at the expense of increased receiver processing. Copyright © 2013 John Wiley & Sons, Ltd.
Performance of a computer‐based assessment of cognitive function measures in two cohorts of seniors
Authors: Espeland Mark A. , Katula Jeffrey A. , Rushing Julia , Kramer Arthur F. , Jennings Janine M. , Sink Kaycee M. , Nadkarni Neelesh K. , Reid Kieran F. , Castro Cynthia M. , Church Timothy , Kerwin Diana R. , Williamson Jeff D. , Marottoli Richard A. , Rushing Scott , Marsiske Michael , Rapp Stephen R. ,   LIFE Study Group
Published: April 2013

BackgroundComputer‐administered assessment of cognitive function is being increasingly incorporated in clinical trials; however, its performance in these settings has not been systematically evaluated.DesignThe Seniors Health and Activity Research Program pilot trial (N = 73) developed a computer‐based tool for assessing memory performance and executive functioning. The Lifestyle Interventions and Independence for Elders investigators incorporated this battery in a full‐scale multicenter clinical trial (N = 1635). We describe relationships that test scores have with those from interviewer‐administered cognitive function tests and risk factors for cognitive deficits and describe performance measures (completeness, intraclass correlations [ICC]).ResultsComputer‐based assessments of cognitive function had consistent relationships across the pilot and full‐scale trial cohorts with interviewer‐administered assessments of cognitive function, age, and a measure of physical function. In the Lifestyle Interventions and Independence for Elders cohort, their external validity was further demonstrated by associations with other risk factors for cognitive dysfunction: education, hypertension, diabetes, and physical function. Acceptable levels of data completeness (>83%) were achieved on all computer‐based measures; however, rates of missing data were higher among older participants (odds ratio = 1.06 for each additional year; p < 0.001) and those who reported no current computer use (odds ratio = 2.71; p < 0.001). ICCs among clinics were at least as low (ICC < 0.013) as for interviewer measures (ICC < 0.023), reflecting good standardization. All cognitive measures loaded onto the first principal component (global cognitive function), which accounted for 40% of the overall variance.ConclusionOur results support the use of computer‐based tools for assessing cognitive function in multicenter clinical trials of older individuals. Copyright © 2013 John Wiley & Sons, Ltd.
Creation of nanoporous TiO2surface onto polyetheretherketone for effective immobilization and delivery of bone morphogenetic protein
Authors: Han Cheol‐Min , Jang Tae‐Sik , Kim Hyoun‐Ee , Koh Young‐Hag 
Published: April 2013

AbstractThis study evaluated the utility of the creation of a nanoporous TiO2surface to enhance thein vitrobiocompatibility andin vivoosseoconductivity of polyetheretherketone (PEEK) implants by providing favorable sites for the effective immobilization of bone morphogenetic protein‐2 (BMP‐2). A uniform nanoporous TiO2layer with a pore diameter of ∼70 nm was successfully created by anodizing a Ti film, which had been deposited onto a PEEK substrate via electron beam (e‐beam) evaporation technique. This nanoporous, hydrophilic TiO2surface enabled the efficient immobilization of BMP‐2, resulting in a remarkable enhancement inin vitrobiocompatibility that was assessed in terms of cell attachment, proliferation, and differentiation. Thein vivoanimal tests also confirmed that the nanoporous TiO2surface immobilized with BMP‐2 could significantly enhance the osseoconductivity of PEEK implants. The BMP‐immobilized PEEK implant with the nanoporous TiO2surface showed much higher bone‐to‐implant contact (BIC) ratio (60%) than the bare PEEK (30%), PEEK with the nanoporous TiO2surface (50%) and even BMP‐immobilized PEEK without the nanoporous TiO2surface (32%). © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 793–800, 2014.