bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of interfirm network management activities: The impact of industry, firm age and size
Authors: Ripollés Maria , Blesa Andreu 
Published: September 2015

AbstractThis article investigates the structural characteristics of firms that promote activities involving partners who coordinate with each other to achieve common or individual goals. The article also aims to verify empirically whether these activities generate advantages for companies embedded in relationships by examining the effects of industry, age and size on interfirm network management activities in a sample of Spanish companies operating in several industries and belonging to networks. The results show differences according to the life cycle stage: growth or maturity. Only the relation between interfirm network management activity and performance has been confirmed in both samples. The findings point to the need to consider the industrial environment when analysing firms’ networking decisions because the situations they face differ in mature or growing industries.
Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism
Authors: Ozaki Yori , Saito Kenji , Nakazawa Kyoko , Konishi Morichika , Itoh Nobuyuki , Hakuno Fumihiko , Takahashi Shin-Ichiro , Kato Hisanori , Takenaka Asako 
Published: September 2015

AbstractProtein malnutrition promotes hepatic steatosis, decreases insulin-like growth factor (IGF)-I production and retards growth. To identify new molecules involved in such changes, we conducted DNA microarray analysis on liver samples from rats fed an isoenergetic low-protein diet for 8 h. We identified the fibroblast growth factor 21 gene (Fgf21) as one of the most strongly up-regulated genes under conditions of acute protein malnutrition (P<0·05, false-discovery rate<0·001). In addition, amino acid deprivation increased Fgf21 mRNA levels in rat liver-derived RL-34 cells (P<0·01). These results suggested that amino acid limitation directly increases Fgf21 expression. FGF21 is a polypeptide hormone that regulates glucose and lipid metabolism. FGF21 also promotes a growth hormone-resistance state and suppresses IGF-I in transgenic mice. Therefore, to determine further whether Fgf21 up-regulation causes hepatic steatosis and growth retardation after IGF-I decrease in protein malnutrition, we fed an isoenergetic low-protein diet to Fgf21-knockout (KO) mice. Fgf21-KO did not rescue growth retardation and reduced plasma IGF-I concentration in these mice. Fgf21-KO mice showed greater epididymal white adipose tissue weight and increased hepatic TAG and cholesterol levels under protein malnutrition conditions (P<0·05). Overall, the results showed that protein deprivation directly increased Fgf21 expression. However, growth retardation and decreased IGF-I were not mediated by increased FGF21 expression in protein malnutrition. Furthermore, FGF21 up-regulation rather appears to have a protective effect against obesity and hepatic steatosis in protein-malnourished animals.
Learning transitive verbs from single-word verbs in the input by young children acquiring English
Authors: NINIO ANAT 
Published: September 2015

AbstractThe environmental context of verbs addressed by adults to young children is claimed to be uninformative regarding the verbs' meaning, yielding the Syntactic Bootstrapping Hypothesis that, for verb learning, full sentences are needed to demonstrate the semantic arguments of verbs. However, reanalysis of Gleitman's (1990) original data regarding input to a blind child revealed the context of single-word parental verbs to be more transparent than that of sentences. We tested the hypothesis that English-speaking children learn their early verbs from parents' single-word utterances. Distribution of single-word transitive verbs produced by a large sample of young children was strongly predicted by the relative token frequency of verbs in parental single-word utterances, but multiword sentences had no predictive value. Analysis of the interactive context showed that objects of verbs are retrievable by pragmatic inference, as is the meaning of the verbs. Single-word input appears optimal for learning an initial vocabulary of verbs.
Patrician Landscapes and the Picturesque in Nottinghamshire c.1750–c.1850
Authors: GAUNT RICHARD A. 
Published: September 2015

Abstract:This article considers the Dukeries estates of north Nottinghamshire in the heyday of aristocratic power and prestige, from the mid Georgian to the mid Victorian period. It poses a contrast between visitors' impressions of the area as one of constancy and continuity, a point of reassurance in an age of political and social upheaval, and the reality of internal changes from within. Closely crowded as these estates were, their aristocratic owners competed with one another to fashion the most economically viable and aesthetically pleasing symbol of status and power. The article pays close attention to the hold which picturesque principles exercised on individual owners and considers the role of plantation, animals and water in parkland management and improvement. Finally, the article considers the extent to which the estates were sites of contestation. Owners attempted to keep unwanted plebeian incursions at bay, whilst carefully controlling access on set-piece occasions such as coming-of-age festivities.
Landowner, Tenant and Agent on the Marquis of Anglesey's Dorset and Somerset Estate, 1814–44
Authors: BEARDMORE CAROL 
Published: September 2015

Abstract:This article uses the surviving correspondence between the Marquis of Anglesey and his land agent William Castleman to explore the relationship which existed between landowner, tenant and agent. The aim of this research has been to examine how these affiliations worked in practice through five broad but interconnecting themes which include: an investigation into the men who became agents, a survey of the changing patterns of land tenure, an evaluation of the estate's reaction to economic downturn, a study of the schemes used to alleviate tenant distress and an analysis of how these estate interactions were reflected in the repairs and improvements undertaken. Castleman was already an experienced attorney and land manager when he began to work for the estate and he and the Marquis developed, over time, a deep and trusting business partnership. Consequently their correspondence has created a historical prism which this article has used to illustrate the working partnerships within this West Country locality.
Heterogeneity in barriers regarding the motivation, the opportunity and the ability to choose low-calorie snack foods and beverages: associations with real-life choices
Authors: Bos Colin , van der Lans Ivo A , van Rijnsoever Frank J , van Trijp Hans CM 
Published: September 2015

AbstractObjectiveEmploying Rothschild’s Motivation–Opportunity–Ability framework, the present study examines the extent to which heterogeneity in barriers regarding the motivation, the perceived opportunity and the perceived ability to choose low-calorie over high-calorie snacks is associated with the proportion of low-calorie snack choices in real life. Furthermore, the study investigates which dominant barrier profiles can be discerned.DesignData were obtained from a survey about participants’ motivation, opportunity and ability to choose low-calorie over high-calorie snacks and an FFQ that measured habitual consumption of snack foods and beverages. Data were analysed using R packages lavaan and NbClust, and IBM SPSS Statistics.SettingA representative sample (n1318) of the Dutch population based on gender (686 women), age and education level.ResultsFor both snack foods and beverages, motivation to choose low-calorie over high-calorie snacks was associated strongest with proportions of low-calorie choices. The perceived ability and perceived opportunity were also associated with proportions of low-calorie choices, albeit to a lesser extent. Furthermore, three dominant profiles of barriers were identified: the no-barrier profile, the lack-of-opportunity profile and the lack-of-motivation profile. These profiles differed significantly on proportions of low-calorie snack choices, daily meal consumption and sociodemographic characteristics.ConclusionsHeterogeneity in barriers regarding the motivation, the perceived opportunity and the perceived ability to choose low-calorie over high-calorie snacks is associated with the proportion of low-calorie snack choices in real life. By identifying and appreciating heterogeneity in barriers, the present study provides further incentives for the tailoring of intervention strategies.
First record of Cassis tuberosa spawning in the wild (north-east Brazil)
Authors: Dias Thelma Lúcia Pereira , Mota Ellori Laíse Silva 
Published: September 2015

Spawning ofCassis tuberosais recorded and described for the first time, based on observations carried out in the Tamandaré reefs, north-eastern Brazil. The specimen was laying over gravel substrate surrounded by macroalgae at a depth of 2 m.Cassis tuberosauses an algal frond of the genusPadinato lay its eggs. The oothecae consists of approximately 200 vasiform capsules, orange in colour. The spawn ofCassis tuberosais quite similar to that produced by its congener,Cassis madagascariensis; however,Cassis tuberosaspawns in the soft substrate provided by algal fronds whileCassis madagascariensisutilizes coarse, carbonate sand. Considering thatCassis tuberosais the target of multiple commercial purposes, to expand our knowledge about its biology could contribute towards protecting the essential habitat of reproductively active individuals.
Controlling and probing non-abelian emergent gauge potentials in spinor Bose-Fermi mixtures
Authors: Phuc Nguyen Thanh , Tatara Gen , Kawaguchi Yuki , Ueda Masahito 
Published: September 2015

AbstractGauge fields, typified by the electromagnetic field, often appear as emergent phenomena due to geometrical properties of a curved Hilbert subspace, and provide a key mechanism for understanding such exotic phenomena as the anomalous and topological Hall effects. Non-abelian gauge potentials serve as a source of non-singular magnetic monopoles. Here we show that unlike conventional solid materials, the non-abelianness of emergent gauge potentials in spinor Bose-Fermi atomic mixtures can be continuously varied by changing the relative particle-number densities of bosons and fermions. The non-abelian feature is captured by an explicit dependence of the measurable spin current density of fermions in the mixture on the variable coupling constant. Spinor mixtures also provide us with a method to coherently and spontaneously generate a pure spin current without relying on the spin Hall effect. Such a spin current is expected to have potential applications in the new generation of atomtronic devices.
Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation
Authors: Manna Sugata , Kim Jong Kyong , Baugé Catherine , Cam Margaret , Zhao Yongmei , Shetty Jyoti , Vacchio Melanie S. , Castro Ehydel , Tran Bao , Tessarollo Lino , Bosselut Rémy 
Published: September 2015

AbstractAlthough histone H3 lysine 27 trimethylation (H3K27Me3) is associated with gene silencing, whether H3K27Me3 demethylation affects transcription and cell differentiation in vivo has remained elusive. To investigate this, we conditionally inactivated the two H3K27Me3 demethylases, Jmjd3 and Utx, in non-dividing intrathymic CD4+ T-cell precursors. Here we show that both enzymes redundantly promote H3K27Me3 removal at, and expression of, a specific subset of genes involved in terminal thymocyte differentiation, especially S1pr1, encoding a sphingosine-phosphate receptor required for thymocyte egress. Thymocyte expression of S1pr1 was not rescued in Jmjd3- and Utx-deficient male mice, which carry the catalytically inactive Utx homolog Uty, supporting the conclusion that it requires H3K27Me3 demethylase activity. These findings demonstrate that Jmjd3 and Utx are required for T-cell development, and point to a requirement for their H3K27Me3 demethylase activity in cell differentiation.
Intraindividual neurophysiological variability in ultra-high-risk for psychosis and schizophrenia patients: single-trial analysis
Authors: Shin Kyung Soon , Kim June Sic , Kim Sung Nyun , Hong Kyung Sue , O’Donnell Brian F , Chung Chun Kee , Kwon Jun Soo 
Published: September 2015

Abstract
Background:
Intraindividual variability in neurophysiological responses is an important factor in the study of schizophrenia. Interestingly, this variability strongly predicts individual differences in cognitive processing. Neurobiological abnormalities that present during the prodromal phase of schizophrenia are not well characterized. However, these symptoms may provide insight into the key circuits involved in the disorder.

Aims:
To investigate the variability in magnetoencephalographic responses at ultrahigh risk and schizophrenia patients.

Methods:
Twenty-four ultrahigh risk, 21 patients with schizophrenia and 28 healthy controls were evaluated. The intraindividual variability was estimated by calculating the s.d. of the across-trial amplitude in responses to deviant and standard stimuli. The degree of phase locking across trials was calculated by intertrial coherence.

Results:
Greater variability in the responses to deviant and standard tones was noted in the schizophrenia and ultrahigh risk groups compared with controls. Variability in response to standard stimuli was positively correlated with the amplitude for the standard stimuli in all of the groups. Moreover, schizophrenia patients displayed lower alpha and theta intertrial coherence compared with ultrahigh risk and controls. Mismatch negativity amplitude was correlated with the alpha intertrial coherence in all groups. Taken together, the augmented variability and reduced inter-trial coherence provide empirical evidence for increased amplitude and phase inconsistencies in schizophrenia and ultrahigh risk.

Conclusions:
The results implicate widespread dysfunction in amplitude modulation and phase concentration in schizophrenia and ultrahigh risk, as well as evidence for early amplitude and phase disruption. These finding suggest intraindividual variability and intertrial coherence appear to be important indicators of pathophysiological processing.
Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in Pancreatic Cancer by the Sequencing of T Cell Receptors
Authors: Bai Xueli , Zhang Qi , Wu Song , Zhang Xiaoyu , Wang Mingbang , He Fusheng , Wei Tao , Yang Jiaqi , Lou Yu , Cai Zhiming , Liang Tingbo 
Published: September 2015

AbstractPancreatic cancer has a poor prognosis and few effective treatments. The failure of treatment is partially due to the high heterogeneity of cancer cells within the tumor. T cells target and kill cancer cells by the specific recognition of cancer-associated antigens. In this study, T cells from primary tumor and blood of sixteen patients with pancreatic cancer were characterized by deep sequencing. T cells from blood of another eight healthy volunteers were also studied as controls. By analyzing the complementary determining region 3 (CDR3) gene sequence, we found no significant differences in the T cell receptor (TCR) repertoires between patients and healthy controls. Types and length of CDR3 were similar among groups. However, two clusters of patients were identified according to the degree of CDR3 overlap within tumor sample group. In addition, clonotypes with low frequencies were found in significantly higher numbers in primary pancreatic tumors compared to blood samples from patients and healthy controls. This study is the first to characterize the TCR repertoires of pancreatic cancers in both primary tumors and matched blood samples. The results imply that specific types of pancreatic cancer share potentially important immunological characteristics.
Chondrocytes-Specific Expression of Osteoprotegerin Modulates Osteoclast Formation in Metaphyseal Bone
Authors: Wang Baoli , Jin Hongting , Shu Bing , Mira Ranim R. , Chen Di 
Published: September 2015

AbstractBone marrow stromal cells/osteoblasts were originally thought to be the major player in regulating osteoclast differentiation through expressing RANKL/OPG cytokines. Recent studies have established that chondrocytes also express RANKL/OPG and support osteoclast formation. Till now, the in vivo function of chondrocyte-produced OPG in osteoclast formation and postnatal bone growth has not been directly investigated. In this study, chondrocyte-specific Opg transgenic mice were generated by using type II collagen promoter. The Col2-Opg transgenic mice showed delayed formation of secondary ossification center and localized increase of bone mass in proximal metaphysis of tibiae. TRAP staining showed that osteoclast numbers were reduced in both secondary ossification center and proximal metaphysis. This finding was further confirmed by in vitro chondrocyte/spleen cell co-culture assay. In contrast, the mineral apposition rates were not changed in Col2-Opg transgenic mice. TUNEL staining revealed more apoptotic hypertrophic chondrocytes in the growth plate of Col2-Opg mice. Flow cytometry analysis showed fewer RANK-expressing cells in the marrow of Col2a1-Opg mice, suggesting the role of OPG in blocking the differentiation of early mesenchymal progenitors into RANK-expressing pre-osteoclasts. Our results demonstrated that OPG expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.
Rapid, high efficiency isolation of pancreatic ß-cells
Authors: Clardy Susan M. , Mohan James F. , Vinegoni Claudio , Keliher Edmund J. , Iwamoto Yoshiko , Benoist Christophe , Mathis Diane , Weissleder Ralph 
Published: September 2015

AbstractThe ability to isolate pure pancreatic ß-cells would greatly aid multiple areas of diabetes research. We developed a fluorescent exendin-4-like neopeptide conjugate for the rapid purification and isolation of functional mouse pancreatic β-cells. By targeting the glucagon-like peptide-1 receptor with the fluorescent conjugate, β-cells could be quickly isolated by flow cytometry and were >99% insulin positive. These studies were confirmed by immunostaining, microscopy and gene expression profiling on isolated cells. Gene expression profiling studies of cytofluorometrically sorted β-cells from 4 and 12 week old NOD mice provided new insights into the genetic programs at play of different stages of type-1 diabetes development. The described isolation method should have broad applicability to the β-cell field.
Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms
Authors: Xu Yuan , Liu Xian , Wang Yulan , Zhou Nannan , Peng Jianlong , Gong Likun , Ren Jing , Luo Cheng , Luo Xiaomin , Jiang Hualiang , Chen Kaixian , Zheng Mingyue 
Published: September 2015

AbstractA combinatorial pharmacophore (CP) model for Multidrug and toxin extrusion 1 (MATE1/SLC47A1) inhibitors was developed based on a data set including 881 compounds. The CP model comprises four individual pharmacophore hypotheses, HHR1, DRR, HHR2 and AAAP, which can successfully identify the MATE1 inhibitors with an overall accuracy around 75%. The model emphasizes the importance of aromatic ring and hydrophobicity as two important structural determinants for MATE1 inhibition. Compared with the pharmacophore model of Organic Cation Transporter 2 (OCT2/ SLC22A2), a functional related transporter of MATE1, the hypotheses of AAAP and PRR5 are suggested to be responsible for their ligand selectivity, while HHR a common recognition pattern for their dual inhibition. A series of analysis including molecular sizes of inhibitors matching different hypotheses, matching of representative MATE1 inhibitors and molecular docking indicated that the small inhibitors matching HHR1 and DRR involve in competitive inhibition, while the relatively large inhibitors matching AAAP are responsible for the noncompetitive inhibition by locking the conformation changing of MATE1. In light of the results, a hypothetical model for inhibiting transporting mediated by MATE1 was proposed.
Polyhedral Palladium–Silver Alloy Nanocrystals as Highly Active and Stable Electrocatalysts for the Formic Acid Oxidation Reaction
Authors: Fu Geng-Tao , Liu Chang , Zhang Qi , Chen Yu , Tang Ya-Wen 
Published: September 2015

AbstractPolyhedral noble–metal nanocrystals have received much attention and wide applications as electrical and optical devices as well as catalysts. In this work, a straightforward and effective hydrothermal route for the controllable synthesis of the high-quality Pd–Ag alloy polyhedrons with uniform size is presented. The morphology, composition and structure of the Pd–Ag alloy polyhedrons are fully characterized by the various physical techniques, demonstrating the Pd–Ag alloy polyhedrons are highly alloying. The formation/growth mechanisms of the Pd–Ag alloy polyhedrons are explored and discussed based on the experimental observations and discussions. As a preliminary electrochemical application, the Pd–Ag alloy polyhedrons are applied in the formic acid oxidation reaction, which shows higher electrocatalytic activity and stability than commercially available Pd black due to the “synergistic effects” between Pd and Ag atoms.
18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination
Authors: Zhou Jieru , Cai Wei , Jin Min , Xu Jingwei , Wang Yanan , Xiao Yichuan , Hao Li , Wang Bei , Zhang Yanyun , Han Jie , Huang Rui 
Published: September 2015

AbstractMicroglia are intrinsic immune cells in the central nervous system (CNS). The under controlled microglia activation plays important roles in inflammatory demyelination diseases, such as multiple sclerosis (MS). However, the means to modulate microglia activation as a therapeutic modality and the underlying mechanisms remain elusive. Here we show that administration of 18β-glycyrrhetinic acid (GRA), by using both preventive and therapeutic treatment protocols, significantly suppresses disease severity of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. The treatment effect of GRA on EAE is attributed to its regulatory effect on microglia. GRA-modulated microglia significantly decreased pro-inflammatory profile in the CNS through suppression of MAPK signal pathway. The ameliorated CNS pro-inflammatory profile prevented the recruitment of encephalitogenic T cells into the CNS, which alleviated inflammation-induced demyelination. In addition, GRA treatment promoted remyelination in the CNS of EAE mice. The induced remyelination can be mediated by the overcome of inflammation-induced blockade of brain-derived neurotrophic factor expression in microglia, as well as enhancing oligodendrocyte precursor cell proliferation. Collectively, our results demonstrate that GRA-modulated microglia suppresses EAE through inhibiting microglia activation-mediated CNS inflammation and promoting neuroprotective effect of microglia, which represents a potential therapeutic strategy for MS and maybe other neuroinflammatory diseases associated with microglia activation.