bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐center reproducibility of neurochemical profiles in the human brain at 7 T
Authors: van de Bank B. L. , Emir U. E. , Boer V. O. , van Asten J. J. A. , Maas M. C. , Wijnen J. P. , Kan H. E. , Oz G. , Klomp D. W. J. , Scheenen T. W. J. 
Published: January 2015

The purpose of this work was to harmonize data acquisition and post‐processing of single voxel proton MRS (1H‐MRS) at 7 T, and to determine metabolite concentrations and the accuracy and reproducibility of metabolite levels in the adult human brain.This study was performed in compliance with local institutional human ethics committees. The same seven subjects were each examined twice using four different 7 T MR systems from two different vendors using an identical semi‐localization by adiabatic selective refocusing spectroscopy sequence. Neurochemical profiles were obtained from the posterior cingulate cortex (gray matter, GM) and the corona radiata (white matter, WM). Spectra were analyzed with LCModel, and sources of variation in concentrations (‘subject’, ‘institute’ and ‘random’) were identified with a variance component analysis.Concentrations of 10–11 metabolites, which were corrected for T1, T2, magnetization transfer effects and partial volume effects, were obtained with mean Cramér–Rao lower bounds below 20%. Data variances and mean concentrations in GM and WM were comparable for all institutions. The primary source of variance for glutamate, myo‐inositol, scyllo‐inositol, total creatine and total choline was between subjects. Variance sources for all other metabolites were associated with within‐subject and system noise, except for total N‐acetylaspartate, glutamine and glutathione, which were related to differences in signal‐to‐noise ratio and in shimming performance between vendors.After multi‐center harmonization of acquisition and post‐processing protocols, metabolite concentrations and the sizes and sources of their variations were established for neurochemical profiles in the healthy brain at 7 T, which can be used as guidance in future studies quantifying metabolite and neurotransmitter concentrations with 1H‐MRS at ultra‐high magnetic field. Copyright © 2015 John Wiley & Sons, Ltd.
Scalable visualization for DBpedia ontology analysis using Hadoop
Authors: Park Seong‐hun , Kim Sung‐min , Ha Young‐guk 
Published: January 2015

SummaryAs ontologies are becoming larger and more diverse, ontological analysis and visualization of results have become more challenging, rendering the need for more computing resources. To address this issue, we suggest a system based on Hadoop for ontological analysis for large ontologies. Our suggested system consists of three parts: a data server to analyze ontological data, a visualization server to visualize the result of data analysis, and user applications to provide users with the visualized data. Server applications are implemented based on the Hadoop framework, and the ontological data are processed efficiently using the MapReduce algorithm. We performed ontological analysis using the DBpedia ontology and visualized the result. The goal of the visualization process is to determine the major properties of each class, and visualization is conducted on the Web in order to provide users with a cross‐platform environment. We evaluate the performance of the method by measuring execution times and analyzing experimental results obtained in the visualization process. The system we present is scalable for big ontological data. Copyright © 2015 John Wiley & Sons, Ltd.
Preventive effect of Rikkunshito, a traditional Japanese medicine, on chemotherapy‐induced nausea and vomiting with cisplatin: Case series
Authors: Kajiura Shinya , Hosokawa Ayumu , Yoshita Hiroki , Ueda Akira , Ando Takayuki , Fujinami Haruka , Nishikawa Jun , Ogawa Kohei , Sugiyama Toshiro 
Published: January 2015

ABSTRACTAimSupportive therapies are important to treat chemotherapy‐induced nausea and vomiting (CINV). Rikkunshito, a Kampo medicine, has been reported to be effective against cisplatin‐induced anorexia in rats. In the present study, we evaluated the preventive effect of Rikkunshito for CINV in patients receiving high‐dose cisplatin chemotherapy.MethodsWe selected patients who received chemotherapy including cisplatin (≥60 mg/m2) for gastric or esophageal cancer between April 2010 and August 2012. We identified 20 patients treated without a reduction in the dose of anticancer medications during the second course and added 7.5 g/day Rikkunshito, which was orally administered, for 7 days. All patients were treated with 5‐hydroxytryptamine‐3 receptor antagonist, corticosteroid, and neurokinin‐1 receptor antagonist for the prevention of CINV during the first and second courses. We evaluated complete response (CR; defined as no emesis and no rescue medication) and other toxicities according to the Common Terminology Criteria for Adverse Events version 4.0.ResultsThe median patient age was 63 years (range, 49–77 years). The chemotherapy regimens used were cisplatin plus 5‐fluorouracil in 15 patients with esophageal cancer and cisplatin plus S‐1 in five patients with gastric cancer. Rate of delayed CR was 75.0% during the first course (95% CI: 56.0–94.0%), which improved during the second course to 95.0% (95% CI: 85.4–100%, P = 0.077). There was no significant difference in other major toxicities between the first and second courses.ConclusionRikkunshito has the potential to alleviate CINV in patients receiving high‐dose cisplatin chemotherapy.
Syntheses, Structures, and Properties of New Niobium Cluster Complexes with Terminal Formate Ligands: ­[AI(CH3OH)n]4­[Nb6Cl12(OCHO)6] (AI = Na, K, Rb, Cs; n = 1, 2)
Authors: Xie Tao , Köckerling Martin 
Published: January 2015

AbstractFour examples of the first hexanuclear niobium cluster complexes with formate ligands, [AI(CH3OH)n]4[Nb6Cl12(OCHO)6] (AI = Na, K, Rb, Cs; n = 1, 2) were prepared. They are obtained from the reaction of [Nb6Cl14(CH3OH)4]·6CH3OH with alkali metal formates in absolute CH3OH. Their structures were determined by single‐crystal X‐ray diffraction. They crystallize in the triclinic space group P$\bar{1}$ and contain isolated cluster anions with formate ligands, which occupy the exo sites of the hexanuclear cluster units. Four AI ions form tetranuclear cationic units, interconnected by oxygen atoms of methanol molecules and of the formate ligands. All compounds comprise network structures of interconnected cluster and complex cation units. Whereas the K, Rb, and the Cs salt contain planar rectangular arrangements of the AI cations, in the Na salt this unit is bent along one diagonal. Electrochemical measurements indicate the possibility of two one‐electron oxidations of the cluster units and possibly one reduction step. The cluster compounds were further characterized by elemental analyses, NMR‐, IR‐, and UV/Vis spectroscopy.
Synthesis of Dinuclear Nickel Complexes from Dimethyltris­(trimethylphosphine)nickel(II) via N–H Bond Activation
Authors: Guo Yingmian , Zhang Xiaohan , Wang Lin , Sun Hongjian , Li Xiaoyan 
Published: January 2015

AbstractThe reactions of N‐arylamidines with NiMe2(PMe3)3 afforded four dinuclear nickel(II) complexes 5–8 via N–H bond activation. Complexes 5–8 were characterized through IR, 1H NMR, 31P NMR, and elemental analysis. The crystal structures of complexes 5 and 7 were determined by X‐ray diffraction.
Frama-C: A software analysis perspective
Authors: Kirchner Florent , Kosmatov Nikolai , Prevosto Virgile , Signoles Julien , Yakobowski Boris 
Published: January 2015

Abstract
Frama-C is a source code analysis platform that aims at conducting verification of industrial-size C programs. It provides its users with a collection of plug-ins that perform static analysis, deductive verification, and testing, for safety- and security-critical software. Collaborative verification across cooperating plug-ins is enabled by their integration on top of a shared kernel and datastructures, and their compliance to a common specification language. This foundational article presents a consolidated view of the platform, its main and composite analyses, and some of its industrial achievements.
Genetic variation for wheat spike fertility in cultivars and early breeding materials
Authors: MIRABELLA N. E. , ABBATE P. E. , RAMIREZ I. A. , PONTAROLI A. C. 
Published: January 2015

SUMMARYGrain yield in bread wheat is often tightly associated with grain number/m2. In turn, spike fertility (SF), i.e., the quotient between grain number and spike chaff dry weight, accounts for a great proportion of the variation in grain number among cultivars. In order to examine the potential use of SF as a breeding target, (1) variation for the trait was assessed in six datasets combining commercial cultivars under different environmental conditions, (2) trait heritability was estimated in a set ofF1hybrids derived from controlled crosses between cultivars with contrasting SF and (3) SF distribution pattern was analysed in twoF2segregating populations. Analysis of commercial cultivars revealed considerable variation for SF, under both optimal and sub-optimal conditions. In addition, genotypic variation was consistently larger than genotype × environment interaction variation in all datasets. Narrow sense heritability, estimated by the mid-parent-offspring regression of 20F1hybrids and their respective parents, was 0·63. Data from twoF2populations exhibited bell-shaped and symmetric frequency distributions of SF, with a SF mean intermediate between the parental values. Substantial transgressive segregation was detected in bothF2populations. In conclusion, SF appears to be a heritable trait with predominantly additive effects. This warrants further investigation on the feasibility of using SF as an early selection criterion in wheat breeding programs aimed at increasing grain yield.
Pre-treatment apparent diffusion coefficient mapping: differentiation of benign from malignant laryngeal lesions
Authors: Taha M S , Amir M , Hassan O , Sabra R , Taha T , Riad M A 
Published: January 2015

AbstractObjective:To determine whether a threshold apparent diffusion coefficient value may help to differentiate laryngeal carcinomas from benign lesions.Methods:Fifty-three patients with laryngeal masses were recruited; four of them were excluded because of susceptibility artefacts. In the remaining 49 patients, the pathological results showed 32 laryngeal carcinomas and 17 benign lesions. The diagnostic value of diffusion-weighted magnetic resonance imaging for the identification of malignant lesions was determined. In addition, the agreement between diffusion-weighted magnetic resonance imaging and histopathology was assessed. Moreover, the sensitivity, specificity, and negative and positive predictive values of the apparent diffusion coefficient in detecting benign and malignant lesions were analysed. An apparent diffusion coefficient histogram was also produced.Results:An apparent diffusion coefficient value of 1.1 × 10−3 mm2/second produced the best result when used as the cut-off point to differentiate malignant from benign masses.Conclusion:An apparent diffusion coefficient threshold of 1.1 × 10−3 mm2/second is optimal for distinguishing laryngeal carcinomas from benign lesions. Apparent diffusion coefficient values were lower for patients with laryngeal carcinomas than for those with benign lesions.
Teilhard De Chardin's Spirituality of the Cross
Authors: Faricy Robert 
Published: January 2015

AbstractThis article studies the spiritual theology of the cross in the writings of Pierre Teilhard de Chardin. In Teilhard's books and articles the accent falls on the cross as a symbol of progress. The cross stands for Jesus' positive act of saving the world through his death; it represents, too, Christian life as a sharing in the cross of Jesus through the labor and pain of human progress. In his spiritual notes, however, Teilhard takes a different perspective. His own meditations on the cross center not on the cross as a positive symbol of personal and collective progress through struggle, but rather on death as the ultimate fragmentation, and as an apparent dead end that is the final passage to Jesus Christ.
Influenza vaccine effectiveness estimates in Croatia in 2010–2011: a season with predominant circulation of A(H1N1)pdm09 influenza virus
Authors: KUREČIĆ FILIPOVIĆ S. , GJENERO-MARGAN I. , KISSLING E. , KAIĆ B. , CVITKOVIĆ A. 
Published: January 2015

SUMMARYThis is a retrospective study using the test-negative case-control method to estimate seasonal 2010–2011 influenza vaccine effectiveness (VE) in Croatia. Of patients consulting a physician for influenza-like illness (ILI) and for whom a swab was taken, we compared RT–PCR influenza-positive and RT–PCR influenza-negative patients. We used a structured questionnaire and physicians' records to obtain information on vaccination status and potential confounders. We conducted a complete case analysis using logistic regression to measure adjusted VE overall, against A(H1N1)pdm09 and in age groups. Out of 785 interviewed patients, 495 eligible patients were included in the study, after applying exclusion criteria [217 cases, of which 92·6% were A(H1N1)pdm09 positive, 278 controls]. Crude VE was 31·9% [95% confidence interval (CI) −40·9 to 67·1] and adjusted VE was 20·7% (95% CI −71·4 to 63·3), with higher VE in youngest and oldest age groups. Results from this first VE study in Croatia suggest a low to moderate VE for the 2010–2011 season. Studies year on year are needed with a greater sample size to provide more precise estimates, and also by age group and risk groups for vaccination.
Support Groups and Cardiac Rehabilitation: Effects of Partner
Participation on Anxiety and Depression
Authors: de Roda Ana Barrón López , Moreno Esteban Sánchez , Montero Isabel Varela , Churnin Steve 
Published: January 2015

AbstractThis study analyzes the effect on levels of patient anxiety and depression of a
partner joining a cardiac rehabilitation program support group, also taking into
account the sex of the patient. The study was undertaken using a two-group
comparison design with pre-and post-test measures in non-equivalent groups. The
sample comprised patients in the cardiac rehabilitation program (CRP) at the
Ramón y Cajal Hospital, Madrid (Spain). Analysis of covariance
(ANCOVA) showed direct effects of sex and partner participation in support
groups on the anxiety trait. Similarly, interaction effects were observed
between the sex variable and partner participation. These results indicate the
pertinence of designing separate groups for patients and partners.
Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate
Authors: Nilsson H , Lindgren D , Mandahl Forsberg A , Mulder H , Axelson H , Johansson M E 
Published: January 2015

AbstractChanges of cellular metabolism are an integral property of the malignant potential of most cancer cells. Already in the 1930s, Otto Warburg observed that tumor cells preferably utilize glycolysis and lactate fermentation for energy production, rather than the mitochondrial oxidative phosphorylation dominating in normal cells, a phenomenon today known as the Warburg effect. Even though many tumor types display a high degree of aerobic glycolysis, they still retain the activity of other energy-producing metabolic pathways. One exception seems to be the clear cell variant of renal cell carcinoma, ccRCC, where the activity of most other pathways than that of glycolysis has been shown to be reduced. This makes ccRCC a promising candidate for the use of glycolytic inhibitors in treatment of the disease. However, few studies have so far addressed this issue. In this report, we show a strikingly reduced mitochondrial respiratory capacity of primary human ccRCC cells, resulting in enhanced sensitivity to glycolytic inhibition by 3-Bromopyruvate (3BrPA). This effect was largely absent in established ccRCC cell lines, a finding that highlights the importance of using biologically relevant models in the search for new candidate cancer therapies. 3BrPA markedly reduced ATP production in primary ccRCC cells, followed by cell death. Our data suggest that glycolytic inhibitors such as 3BrPA, that has been shown to be well tolerated in vivo, should be further analyzed for the possible development of selective treatment strategies for patients with ccRCC.
A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability
Authors: Li P , Ma X , Adams I R , Yuan P 
Published: January 2015

AbstractProlonged culture of embryonic stem cells (ESCs) leads them to adopt embryonal carcinoma cell features, creating enormous dangers for their further application. The mechanism involved in ESC stability has not, however, been extensively studied. We previously reported that SMAD family member 3 (Smad3) has an important role in maintaining mouse ESC stability, as depletion of Smad3 results in cancer cell-like properties in ESCs and Smad3−/− ESCs are prone to grow large, malignant teratomas. To understand how Smad3 contributes to ESC stability, we performed microarray analysis to compare the transcriptome of wild-type and Smad3−/− ESCs. We found that Rif1 (RAP1-associated protein 1), a factor important for genomic stability, is significantly upregulated in Smad3−/− ESCs. The expression level of Rif1 needs to be tightly controlled in ESCs, as a low level of Rif1 is associated with ESC differentiation, but a high level of Rif1 is linked to ESC transformation. In ESCs, Oct4 activates Rif1, whereas Smad3 represses its expression. Oct4 recruits Smad3 to bind to Rif1 promoter, but Smad3 joining facilitates the loading of a polycomb complex that generates a repressive epigenetic modification on Rif1 promoter, and thus maintains the expression of Rif1 at a proper level in ESCs. Interestingly, Rif1 short hairpin RNA (shRNA)-transduced Smad3−/− ESCs showed less malignant properties than the control shRNA-transduced Smad3−/− ESCs, suggesting a critical role of Rif1 in maintaining the stability of ESCs during proliferation.
Artificial magnetic field induced by an evanescent wave
Authors: Mochol Małgorzata , Sacha Krzysztof 
Published: January 2015

AbstractCold atomic gases are perfect laboratories for realization of quantum simulators. In order to simulate solid state systems in the presence of magnetic fields special effort has to be made because atoms are charge neutral. There are different methods for realization of artificial magnetic fields, that is the creation of specific conditions so that the motion of neutral particles mimics the dynamics of charged particles in an effective magnetic field. Here, we consider adiabatic motion of atoms in the presence of an evanescent wave. Theoretical description of the adiabatic motion involves artificial vector and scalar potentials related to the Berry phases. Due to the large gradient of the evanescent field amplitude, the potentials can be strong enough to induce measurable effects in cold atomic gases. We show that the resulting artificial magnetic field is able to induce vortices in a Bose-Einstein condensate trapped close to a surface of a prism where the evanescent wave is created. We also analyze motion of an atomic cloud released from a magneto-optical trap that falls down on the surface of the prism. The artificial magnetic field is able to reflect falling atoms that can be observed experimentally.
Adolescent Outcomes of Children With Early Speech Sound Disorders With and Without Language Impairment
Authors: Lewis Barbara A. , Freebairn Lisa , Tag Jessica , Ciesla Allison A. , Iyengar Sudha K. , Stein Catherine M. , Taylor H. Gerry 
Published: January 2015

Purpose
In this study, the authors determined adolescent speech, language, and literacy outcomes of individuals with histories of early childhood speech sound disorders (SSD) with and without comorbid language impairment (LI) and examined factors associated with these outcomes.

Method

This study used a prospective longitudinal design. Participants with SSD (
n
= 170), enrolled at early childhood (4–6 years) were followed at adolescence (11–18 years) and were compared to individuals with no histories of speech or language impairment (no SSD;
n
= 146) on measures of speech, language, and literacy. Comparisons were made between adolescents with early childhood histories of no SSD, SSD only, and SSD plus LI as well as between adolescents with no SSD, resolved SSD, and persistent SSD.

Results
Individuals with early childhood SSD with comorbid LI had poorer outcomes than those with histories of SSD only or no SSD. Poorer language and literacy outcomes in adolescence were associated with multiple factors, including persistent speech sound problems, lower nonverbal intelligence, and lower socioeconomic status. Adolescents with persistent SSD had higher rates of comorbid LI and reading disability than the no SSD and resolved SSD groups.

Conclusion
Risk factors for language and literacy problems in adolescence include an early history of LI, persistent SSD, lower nonverbal cognitive ability, and social disadvantage.
Real Enough: Using Virtual Public Speaking Environments to Evoke Feelings and Behaviors Targeted in Stuttering Assessment and Treatment
Authors: Brundage Shelley B. , Hancock Adrienne B. 
Published: January 2015

Purpose

Virtual reality environments
(VREs) are computer-generated, 3-dimensional worlds that allow users to experience situations similar to those encountered in the real world. The purpose of this study was to investigate VREs for potential use in assessing and treating persons who stutter (PWS) by determining the extent to which PWS's affective, behavioral, and cognitive measures in a VRE correlate with those same measures in a similar live environment.

Method
Ten PWS delivered speeches—first to a live audience and, on another day, to 2 virtual audiences (neutral and challenging audiences). Participants completed standard tests of communication apprehension and confidence prior to each condition, and frequency of stuttering was measured during each speech.

Results
Correlational analyses revealed significant, positive correlations between virtual and live conditions for affective and cognitive measures as well as for frequency of stuttering.

Conclusions
These findings suggest that virtual public speaking environments engender affective, behavioral, and cognitive reactions in PWS that correspond to those experienced in the real world. Therefore, the authentic, safe, and controlled environments provided by VREs may be useful for stuttering assessment and treatment.
Multiaddressable molecular rectangles with reversible host–guest interactions: Modulation of pH-controlled guest release and capture
Authors: Chan Alan Kwun-Wa , Lam Wai Han , Tanaka Yuya , Wong Keith Man-Chung , Yam Vivian Wing-Wah 
Published: January 2015

Significance
There has been considerable interest in the construction of stimuli-responsive metallosupramolecular architectures because of their versatile structural and bonding properties, imparting them with the capability to exhibit specific functions. Despite a variety of metal–organic architectures reported, those involving noncovalent metal–metal interactions and luminescence changes that depend on the nature of the guests are rather underexplored. Herein, a series of alkynylplatinum(II) terpyridine molecular rectangles has been shown to exhibit reversible capture and release of anticancer therapeutic guests under different pH conditions with instant and drastic color and luminescence responses. The fundamental understanding of these host–guest interactions has led to the development of a unique proof-of-principle multiaddressable model system that illustrates the capability of reversible guest capture and release processes for therapeutic delivery.