bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe Prenatal Renal Anomalies Associated with Mutations in HNF1B or PAX2 Genes
Authors: Madariaga Leire , Morinière Vincent , Jeanpierre Cécile , Bouvier Raymonde , Loget Philippe , Martinovic Jelena , Dechelotte Pierre , Leporrier Nathalie , Thauvin-Robinet Christel , Jensen Uffe Birk , Gaillard Dominique , Mathieu Michele , Turlin Bruno , Attie-Bitach Tania , Salomon Rémi , Gübler Marie-Claire , Antignac Corinne , Heidet Laurence 
Published: March 2013

Summary

Background and objectives
Congenital anomalies of the kidney and urinary tract (CAKUT) are a frequent cause of renal failure in children, and their detection in utero is now common with fetal screening ultrasonography. The clinical course of CAKUT detected before birth is very heterogeneous and depends on the level of nephron reduction. The most severe forms cause life-threatening renal failure, leading to perinatal death or the need for very early renal replacement therapy.

Design, setting, participants, & measurements
This study reports the screening of two genes (HNF1B and PAX2) involved in monogenic syndromic CAKUT in a cohort of 103 fetuses from 91 families with very severe CAKUT that appeared isolated by fetal ultrasound examination and led to termination of pregnancy.

Results
This study identified a disease-causing mutation in HNF1B in 12 cases from 11 families and a mutation in PAX2 in 4 unrelated cases. Various renal phenotypes were observed, but no case of bilateral agenesis was associated with HNF1B or PAX2 mutations. Autopsy identified extrarenal abnormalities not detected by ultrasonography in eight cases but confirmed the absence of extrarenal defects in eight other cases. A positive family history of renal disease was not significantly more frequent in cases with an identified mutation. Moreover, in cases with an inherited mutation, there was a great phenotypic variability regarding the severity of the renal disease within a single family.

Conclusions
Our results suggest that mutations in genes involved in syndromic CAKUT with Mendelian inheritance are not rare in fetal cases with severe CAKUT appearing isolated at prenatal ultrasound, a finding of clinical importance because of genetic counseling.
Adverse Drug Events during AKI and Its Recovery
Authors: Cox Zachary L. , McCoy Allison B. , Matheny Michael E. , Bhave Gautam , Peterson Neeraja B. , Siew Edward D. , Lewis Julia , Danciu Ioana , Bian Aihua , Shintani Ayumi , Ikizler T. Alp , Neal Erin B. , Peterson Josh F. 
Published: March 2013

Summary

Background and objectives
The impact of AKI on adverse drug events and therapeutic failures and the medication errors leading to these events have not been well described.

Design, setting, participants, & measurements
A single-center observational study of 396 hospitalized patients with a minimum 0.5 mg/dl change in serum creatinine who were prescribed a nephrotoxic or renally eliminated medication was conducted. The population was stratified into two groups by the direction of their initial serum creatinine change: AKI and AKI recovery. Adverse drug events, potential adverse drug events, therapeutic failures, and potential therapeutic failures for 148 drugs and 46 outcomes were retrospectively measured. Events were classified for preventability and severity by expert adjudication. Multivariable analysis identified medication classes predisposing AKI patients to adverse drug events.

Results
Forty-three percent of patients experienced a potential adverse drug event, adverse drug event, therapeutic failure, or potential therapeutic failure; 66% of study events were preventable. Failure to adjust for kidney function (63%) and use of nephrotoxic medications during AKI (28%) were the most common potential adverse drug events. Worsening AKI and hypotension were the most common preventable adverse drug events. Most adverse drug events were considered serious (63%) or life-threatening (31%), with one fatal adverse drug event. Among AKI patients, administration of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, antibiotics, and antithrombotics was most strongly associated with the development of an adverse drug event or potential adverse drug event.

Conclusions
Adverse drug events and potential therapeutic failures are common and frequently severe in patients with AKI exposed to nephrotoxic or renally eliminated medications.
A Model of Individual Accounting Faculty Salaries
Authors: Almer Elizabeth Dreike , Bertolini Michelle , Higgs Julia L. 
Published: March 2013

ABSTRACT:
While much has been written about how to successfully manage an academic accounting career, to date, research has not considered how accounting academics can manage their career to impact their salary. The current study utilizes publicly available individual salary information for over 1,200 tenure-track faculty at over 100 of the largest accounting programs in U.S. public universities. Using this salary data, we create a model of accounting faculty salary using individual and institutional variables for top-ranked doctoral, other doctoral, and non-doctoral programs.
Our results offer additional insights into accredited public university accounting faculty salaries beyond the Association to Advance Collegiate Schools of Business (AACSB) publications, which aggregate by public/private schools and accredited/non-accredited programs.
We find that Brigham Young University (BYU) 20 faculty research ranking, a financial teaching/research emphasis, being a department chair, and having a named business school can be positively associated with salary, although the specific influence varies by type of program. There is generally a U-shaped relationship between salary and academic rank, but a negative relationship with length of employment at an institution and cost of living. A systems teaching/research emphasis is negatively associated with salary at other doctoral programs. We do not find that salary is associated with gender.
Infarction of the lateral posterior choroidal artery territory after manipulation of the choroid plexus at the atrium: causal association with subependymal artery injury
Authors: Saito Ryuta , Kumabe Toshihiro , Sonoda Yukihiko , Kanamori Masayuki , Mugikura Shunji , Takahashi Shoki , Tominaga Teiji 
Published: March 2013

Object
The atrium of the lateral ventricle is often affected by tumors, and some patients with these tumors suffer neurological deficits, including hemiparesis after surgery. The authors of this study investigated the possible mechanisms causing the relatively high incidences of ischemic complications associated with surgery approaching the atrium of the lateral ventricle.

Methods
Clinical records and radiological images of 28 patients were retrospectively studied. These patients had their lateral ventricles opened at the atrium during the resection of gliomas as well as other nonbenign brain tumors, and were treated for gliomas at our tertiary referral center in the Tohoku district, Japan, between January 2008 and December 2010.

Results
Routine postoperative diffusion-weighted MR images obtained within 72 hours after surgery detected infarction in the periatrial/periventricular regions in 7 patients, presumably corresponding to the lateral posterior choroidal artery (LPChA) territory. Five of these 7 patients suffered neurological sequelae with varying severities. The choroid plexus at the atrium was coagulated to achieve hemostasis during the surgery in all of these patients. Detailed analysis of microangiograms revealed ventriculofugal arteries arising from the lateral ventricle. Damage of the subependymal artery that supplies the ventriculofugal arteries caused by coagulation of the choroid plexus at the atrium probably resulted in the infarction in these patients.

Conclusions
Neurosurgeons must be aware of the possibility of LPChA territory infarction during surgery in the atrial or periatrial regions caused by subependymal artery obstruction after manipulating or coagulating the choroid plexus near the atrium.
Detection of β-amyloid oligomers as a predictor of neurological outcome after brain injury
Authors: Gatson Joshua Wayne , Warren Victoria , Abdelfattah Kareem , Wolf Steven , Hynan Linda S. , Moore Carol , Diaz-Arrastia Ramon , Minei Joseph P. , Madden Christopher , Wigginton Jane G. 
Published: March 2013

Object
Traumatic brain injury (TBI) is known to be a risk factor for Alzheimer-like dementia. In previous studies, an increase in β-amyloid (Aβ) monomers, such as β-amyloid 42 (Aβ42), in the CSF of patients with TBI has been shown to correlate with a decrease in amyloid plaques in the brain and improved neurological outcomes. In this study, the authors hypothesized that the levels of toxic high-molecular-weight β-amyloid oligomers are increased in the brain and are detectable within the CSF of TBI patients with poor neurological outcomes.

Methods
Samples of CSF were collected from 18 patients with severe TBI (Glasgow Coma Scale Scores 3–8) and a ventriculostomy. In all cases the CSF was collected within 72 hours of injury. The CSF levels of neuron-specific enolase (NSE) and Aβ42 were measured using enzyme-linked immunosorbent assay. The levels of high-molecular-weight β-amyloid oligomers were measured using Western blot analysis.

Results
Patients with good outcomes showed an increase in the levels of CSF Aβ42 (p = 0.003). Those with bad outcomes exhibited an increase in CSF levels of β-amyloid oligomers (p = 0.009) and NSE (p = 0.001). In addition, the CSF oligomer levels correlated with the scores on the extended Glasgow Outcome Scale (r = −0.89, p = 0.0001), disability rating scale scores (r = 0.77, p = 0.005), CSF Aβ42 levels (r = −0.42, p = 0.12), and CSF NSE levels (r = 0.70, p = 0.004). Additionally, the receiver operating characteristic curve yielded an area under the curve for β-amyloid oligomers of 0.8750 ± 0.09.

Conclusions
Detection of β-amyloid oligomers may someday become a useful clinical tool for determining injury severity and neurological outcomes in patients with TBI.
Role of magnetic resonance ventriculography in multiloculated hydrocephalus
Authors: Gandhoke Gurpreet S. , Frassanito Paolo , Chandra Nagesh , Ojha Bal K. , Singh Anoop 
Published: March 2013

Object
In this paper the authors' goal was to investigate the clinical usefulness of Gd-enhanced MR ventriculography (MRV) in pediatric patients affected by multiloculated hydrocephalus.

Methods
Eighteen patients (11 boys and 7 girls, age range 2–14 months) with a diagnosis of multiloculated hydrocephalus were included in the study. After injection of gadodiamide (0.02–0.04 mmol) into the lateral ventricle by tapping the anterior fontanel, sagittal, coronal, and axial T1-weighted MR images were acquired. The location of the septations and the sites of obstruction of CSF flow were assessed. Postoperative MRV was obtained to confirm the results of endoscopic treatment in most complex cases.

Results
No adverse events were observed after injection of contrast medium into the ventricular system. Preoperative MRV accurately defined the exact morphology of septae and ventricular walls in all cases. In 1 case the diagnosis of multiloculated hydrocephalus was ruled out. Sites of obstruction of CSF flow within the ventricular system were also well established. In 4 cases the multiple compartments were proven to intercommunicate. Postoperative MRV was useful in assessing the functional status of third ventriculostomy, aqueductoplasty, and other endoscopic fenestrations.

Conclusions
Magnetic resonance ventriculography is a safe, effective, and reliable technique. The accurate definition of the anatomy of the ventricles and the site of obstruction in multiloculated hydrocephalus can help to plan the most appropriate treatment and minimize the number of procedures. Although MRV is also useful during postoperative follow-up to determine the results of endoscopic treatment, it should be limited to particularly complex cases, due to its invasiveness.
Réforme française de l'allocation dépendance et gestion départementale
Authors: Frinault Thomas 
Published: March 2013

Échappant à l’alternative entre convergence et résilience des régimes providentiels, la réforme française de l’allocation dépendance trace une voie de réforme inédite et irréductible. Élaborée à la croisée des enjeux de protection sociale et de décentralisation, cette réforme requiert l’étude des influences réciproques entre les enjeux inhérents à la solidarité et ceux relatifs au Département. D’un côté, la réforme dépendance renforce l’emprise d’un « département providence » dont l’action déborde de plus en plus le cadre traditionnel d’intervention de l’Aide sociale. De l’autre côté, la préservation de l’héritage décentralisateur, valorisant une gestion de proximité moins administrative, correspond aussi à une stratégie de délestage de compétences inflationnistes sur les gouvernements locaux. L’instrumentalisation financière représente ainsi le prix à payer par les départements pour préserver leur existence.
Eight Novel Microsatellite Loci Developed from Vernal Pool Fairy Shrimp
Authors: Deiner Kristy , Hull Joshua M. , May Bernie 
Published: March 2013

Abstract
We developed primer sets for eight di-, tri-, and tetranucleotide microsatellite loci for the threatened vernal pool fairy shrimp Branchinecta lynchi from CA, CAA, ATG, CAGA, and TAGA enriched genomic libraries. We tested primers in 74 individuals of B. lynchi from California, as well as 19 individuals from six other Branchinecta species: B. coloradensis, B. constricta, B. dissimilis, B. lindahli, B. mesovalensis, and B. oriena. The eight loci showed sufficient variability for investigations of B. lynchi evolution, population structure, and genetic diversity and may provide a new tool for assisting in delineation of management areas.
Application ofDNAMicroarray in Studies of Herbal Dietary Supplements
Authors: Guo Lei , Fuscoe James C. , Fu P. , Mei Nan 
Published: March 2013

AbstractHerbal dietary supplements are used extensively worldwide and the consumption has dramatically increased in the United States in recent years. Although side effects of many herbal dietary supplements have been reported, safety assurance has not been addressed adequately and toxicological data on most herbal dietary supplements are lacking. To address the issue of human health protection, there are currently more than 30 herbal dietary supplements or active ingredients under study by the US National Toxicology Program (NTP). Herbal products often exhibit great variability in quality because of different processing methods, cultivation conditions, and harvest time, as well as the strain and species differences. Authentication of plant species used for preparation of herbal dietary supplements is a critical step of safety assurance. Botanical extracts differ from drugs in that they are mixtures of many active constituents. At present, there are no well‐established methodologies for evaluating the toxicity or determining the toxic mechanisms of herbal plant extracts due to the complexity of chemical components. In this chapter, we describe the applications of DNA microarray for plant authentication and mechanistic studies of herbal dietary supplements.
Leptomeningeal collaterals are associated with modifiable metabolic risk factors
Authors: Menon Bijoy K. , Smith Eric E. , Coutts Shelagh B. , Welsh Donald G. , Faber James E. , Goyal Mayank , Hill Michael D. , Demchuk Andrew M. , Damani Zaheed , Cho Kyung‐Hee , Chang Hyuk‐Won , Hong Jeong‐Ho , Sohn Sung Il 
Published: March 2013

ObjectiveWe sought to identify potentially modifiable determinants associated with variability in leptomeningeal collateral status in patients with acute ischemic stroke.MethodsData are from the Keimyung Stroke Registry. Consecutive patients with M1 segment middle cerebral artery ± intracranial internal carotid artery occlusions on baseline computed tomographic angiography (CTA) from May 2004 to July 2009 were included. Baseline and follow‐up imaging was analyzed blinded to all clinical information. Two raters assessed leptomeningeal collaterals on baseline CTA by consensus, using a previously validated regional leptomeningeal score (rLMC).ResultsBaseline characteristics (N = 206) were: mean age = 66.9 ± 11.6 years, median baseline National Institutes of Health Stroke Scale = 14 (interquartile range [IQR] = 11–20), and median time from stroke symptom onset to CTA = 166 minutes (IQR = 96–262). Poor collateral status at baseline (rLMC score = 0–10) was seen in 73 of 206 patients (35.4%). On univariate analyses, patients with poor collateral status at baseline were older; were hypertensive; had higher white blood cell count, blood glucose, D‐dimer, and serum uric acid levels; and were more likely to have metabolic syndrome. Multivariate modeling identified metabolic syndrome (odds ratio [OR] = 3.22, 95% confidence interval [CI] = 1.69–6.15, p < 0.001), hyperuricemia (per 1mg/dl serum uric acid; OR = 1.35, 95% CI = 1.12–1.62, p < 0.01), and older age (per 10 years; OR = 1.34, 95% CI = 1.02–1.77, p = 0.03) as independent predictors of poor leptomeningeal collateral status at baseline.InterpretationMetabolic syndrome, hyperuricemia, and age are associated with poor leptomeningeal collateral status in patients with acute ischemic stroke. Ann Neurol 2013;74:241–248
Neue Wasserstände für die Bemessung von Hochwasserschutzwänden und Uferbauwerken im Hamburger Hafen
Authors: Heil H. , Powroschnik L. , Claussen A. , Glimm M. , Möller B. 
Published: March 2013

AbstractDer Hafen von Hamburg liegt im Tidebereich der Elbe. Der mittlere Tidenhub beträgt ca. 3,50 m. Für die Bemessung von Hochwasserschutzanlagen und Uferbauwerken ist es erforderlich, die Einflüsse der Tiden auf die Bauwerke zu berücksichtigen. Aufgrund höher auflaufender Tidewasserstände wurde es erforderlich, neue Bemessungsvorgaben für die Hafenbauwerke festzulegen. Hierzu wurden an unterschiedlichen Querschnittstypen instationäre Berechnungen der tideabhängigen Grundwasserströmung nach der Methode der Finiten Elemente durchgeführt. Die angesetzten Materialparameter wurden durch Vergleich der berechneten mit den an Bauwerken gemessenen tideabhängigen Grundwasserständen kalibriert. Aus den Rechenergebnissen wurden Bemessungsvorgaben abgeleitet, die Eingang in die neu aufgestellten "Technischen Rahmenbedingungen für die Fördermaßnahme PROJEKT PRIVATER HOCHWASSERSCHUTZ" der Freien und Hansestadt Hamburg für Uferbauwerke an Tidegewässern von Bedeutung.
Zur Anwendung der Bruchlinientheorie in der Praxis
Authors: Avellan K. , Werkle H. 
Published: March 2013

AbstractDie nach EC 2 zugelassene Bruchlinientheorie ist ein einfaches Berechungsverfahren, mit dem sich der Versagenszustand von Stahlbetonplatten behandeln läßt. Es werden die grundlegenden Formeln in einer für die Programmierung geeigneten allgemeinen Form angegeben. Sie lassen sich für Platten mit rechteckwinkliger Berandung und orthogonaler Bewehrung für die Handrechnung vereinfachen. Anhand von Berechnungsbeispielen werden die Anwendung des Verfahrens sowie einige Eigenschaften verdeutlicht. Weiterhin werden Empfehlungen zu sinnvollen Annahmen der Bemessungskennwerte in der Praxis sowie Hinweise für eine pragmatische und effiziente Bemessung von Platten nach der Bruchlinientheorie gegeben.
Kombination von Einwirkungen. Eine Betrachtung zu den Formulierungen in den Eurocodes und ein Vorschlag für eine vereinfachte Kombinationsregel
Authors: Fischer L. 
Published: March 2013

AbstractIn den Eurocodes erfolgt die Kombination der Einwirkungen nach zwei Regeln ‐ der Grundkombination und der vereinfachten Kombination. Beide Regeln besitzen den Status von "Anwendungsregeln". Im Fall ständiger und vorübergehender Bemessungssituationen im Grenzzustand der Tragfähigkeit und im Fall der charakteristischen (seltenen) Kombinationen im Grenzzustand der Gebrauchstauglichkeit steht die vereinfachte Kombination für Hochbauten nicht mit den "Prinzipien" in Übereinstimmung. Ein Vorschlag für eine vereinfachte Kombinationsregel wird in dieser Veröffentlichung unterbreitet, die mit der Grundkombinationsregel konsistent ist. Schließlich wird eine Empfehlung an die Bauingenieure zum Studium der Methode der Grenzzustände gegeben.
Untersuchung zur Meßgenauigkeit von Inklinometermessungen
Authors: Marte R. , Semprich S. 
Published: March 2013

AbstractZur Bestimmung horizontaler Verschiebungen im Boden oder im Boden eingebetteter Bauwerke hat sich die Anwendung von Inklinometermeßverfahren bewährt. Speziell bei der Beobachtung von Kriechhängen wie auch von verformungsempfindlichen Baugrubenwänden wird dabei eine zunehmende Genauigkeit dieser Meßsysteme gefordert. Um diesen Anforderungen Genüge leisten zu können, ist die Kenntnis der diesen Meßsystemen eigenen Fehler und der Streuungseigenschaften der Meßdaten von Bedeutung. In dem vorliegenden Beitrag wird der Vertrauensbereich von Inklinometermeßergebnissen von vertikal wie auch geneigt eingebauten Inklinometerrohren erörtert und mathematische Zusammenhänge beschrieben.
Neues Verfahren für die Bemessung von Stahlspundwänden
Authors: Hartmann‐Linden R. , Schmitt A. , Sedlacek G. 
Published: March 2013

AbstractIm Rahmen der europäischen Vereinheitlichung der Bemessungsregeln im konstruktiven Ingenieurbau wurde in den letzten Jahren auch eine Norm für die Bemessung von Stahlspundwänden und Stahlpfählen erarbeitet, der Eurocode 3, Teil 5. Diese Norm basiert auf dem Grenzzustandskonzept, welches für alle Eurocodes verbindlich eingeführt wurde. Im folgenden soll die Bemessung von Stahlspundwänden nach dem Grenzzustandskonzept erläutert werden, wobei das Verhalten der Spundwandprofile im Vordergrund steht.
Zur Debatte um die Theoreme von Castigliano in der klassischen Baustatik
Authors: Kurrer K.‐E. 
Published: March 2013

AbstractNach Darstellung des wissenschaftlichen Werkes von Castigliano wird die Rezeption der Theoreme von Castigliano in den 80er Jahren des 19. Jahrhunderts durch deutsche Technikwissenschaftler skizziert. Während Mohr den Geltungsanspruch der Theoreme von Castigliano für die Grundlegung der klassischen Baustatik abstritt, vollendete Müller‐Breslau mit der sukzessiven Erweiterung des Ausdrucks der Formänderungsenergie für elastische Stabwerke die klassische Baustatik. So durchherrschte der energetische Imperativ schon um 1900 Theorie und Praxis der Baustatik. Dennoch versuchten im ersten Dezennium dieses Jahrhunderts Weingarten und Mehrtens die Herrschaft der Theoreme von Castigliano zu brechen. Die Debatte darum erscheint als Wiederaufnahmeverfahren des vergangenen Streits zwischen Mohr und Müller‐Breslau, das stark von Prioritätsfragen überlagert wurde. 1910 konnte die Debatte von Weyrauch zugunsten der Herrschaft der Theoreme von Castigliano in der klassischen Baustatik abgeschlossen werden.
Korrosion von Vollholz und Brettschichtholz
Authors: Erler K. 
Published: March 2013

AbstractHolz ist ein korrosionsträger Baustoff. Daher haben Baukonstruktionen aus Holz besonders bei korrosionsfördernden Einwirkungen wie hohe Luftfeuchte oder aggressive Medien eine längere Lebensdauer als bei Bauten aus Stahl oder Beton. Im vorliegenden Beitrag werden Umstände und Bedingungen bewertet, unter denen Holz korrodiert, und der Einfluß aggressiver Medien auf die Schädigung von Holzbauteilen und die Auswirkungen auf die Tragfähigkeit beschrieben. Dabei werden verschiedene Korrosionsarten wie z. B. chemische oder mechanische Zerstörung und Auslaugung unterschieden und Korrosionsraten sowie Beanspruchungsgrade definiert. Es wird gezeigt, daß vor allem Brettschichtholz auch nach Standzeiten von 20 oder 30 Jahren korrosionsbeständiger als Vollholz ist.
Der Brettstapel als Verbundelement ‐ Vorschlag für einen Berechnungsansatz
Authors: Braun H.‐J. , Schaal W. , Schneck F. 
Published: March 2013

AbstractEs wird die Brettstapel‐Beton‐Verbundbauweise als eine spezielle Form der Holz‐Beton‐Verbundkombination vorgestellt. Aufbauend auf einem Belastungsversuch wird ein Berechnungsansatz für ein solches Deckenelement hergeleitet. Der Verbundfuge wird dabei besondere Aufmerksamkeit geschenkt. Es wird gezeigt, daß eine Nachweisführung nach dem deutschen bzw. europäischen Regelwerk möglich ist. Ein ausführliches Berechnungsbeispiel rundet den Beitrag praxisnah ab.