bluuebunny/crossref_metadata_2025_split huggingface dataset:
CX43 and oxidative stress are the targets of BCB staining to predict the developmental potential of buffalo oocytes
Authors: Li MengQi , Yang ChunYan , Duan AnQin , Xiao Peng , Lu XingRong , Ma XiaoYa , Xu YuanYuan , Zheng Wei , Feng Chao , Mo Xia , Huang ChenQian , Huang LiQing , Shang JiangHua , Zheng HaiYing 
Published: August 2024

AbstractThis study used the brilliant cresyl blue (BCB) staining method to group buffalo oocytes (BCB+ and BCB−) and perform in vitro maturation, in vitro fertilization and embryo culture. At the same time, molecular biology techniques were used to detect gap junction protein expression and oxidative stress‐related indicators to explore the molecular mechanism of BCB staining to predict oocyte developmental potential. The techniques of buffalo oocytes to analyse their developmental potential and used immunofluorescence staining to detect the expression level of CX43 protein, DCFH‐DA probe staining to detect ROS levels and qPCR to detect the expression levels of the antioxidant‐related genes SOD2 and GPX1. Our results showed that the in vitro maturation rate, embryo cleavage rate and blastocyst rate of buffalo oocytes in the BCB+ group were significantly higher than those in the BCB− group and the control group (p < .05). The expression level of CX43 protein in the BCB+ group was higher than that in the BCB− group both before and after maturation (p < .05). The intensity of ROS in the BCB+ group was significantly lower than that in the BCB− group (p < .05), and the expression levels of the antioxidant‐related genes SOD2 and GPX1 in the BCB+ group were significantly higher than those in the BCB− group (p < .05). Brilliant cresyl blue staining could effectively predict the developmental potential of buffalo oocytes. The results of BCB staining were positively correlated with the expression of gap junction protein and antioxidant‐related genes and negatively correlated with the reactive oxygen species level, suggesting that the mechanism of BCB staining in predicting the developmental potential of buffalo oocytes might be closely related to antioxidant activity.
Efficacy of stromal vascular fraction in the treatment of scars: A systematic review and meta‐analysis
Authors: Qiu Kaizhen , Gan Wenjun , Chen Xiaodong 
Published: August 2024

AbstractObjectiveOur aim was to assess the effectiveness of stromal vascular fraction (SVF) in treating scars using the latest meta‐analysis.MethodsWe used PubMed, Embase, Cochrane, and Web of Science to search the studies used to evaluate the efficacy of SVF in scar treatment. At least one of the following outcome measures were reported: vascularity, pigmentation, thickness, relief, pliability, surface area, pain, itching and color.ResultsA total of four eligible articles comprising 145 patients (64 SVF patients and 81 non‐SVF patients) were included. The findings of this meta‐analysis indicated that SVF had significant therapeutic effects in terms of vascularity (SMD/MD, 95% CI: ‐1.12, ‐0.02; p = 0.04), itching (SMD/MD, 95% CI: ‐0.61, ‐0.13; p = 0.002), POSAS (SMD/MD, 95% CI: ‐5.93, ‐1.47; p = 0.001), and thickness (SMD/MD, 95% CI: ‐1.04, ‐0.35; p < 0.001). In terms of OSAS (SMD/MD, 95% CI: ‐9.14, 0.59; p = 0.09), pigmentation (SMD/MD, 95% CI: ‐1.02, 0.06; p = 0.08), relief (SMD/MD, 95% CI: ‐1.14, 0.16; p = 0.14), surface area (SMD/MD, 95% CI: ‐0.91, 0.26; p = 0.27), PSAS (SMD/MD, 95% CI: ‐7.20, 0.49; p = 0.09), pain (SMD/MD, 95% CI: ‐0.87, 0.07; p = 0.10), pliability (SMD/MD, 95% CI: ‐0.57, 0.01; p = 0.06), and color (SMD/MD, 95% CI: ‐1.78, 0.48; p = 0.26), there were no significant statistical differences.ConclusionIn view of the heterogeneity and potential selective bias, further large‐scale, prospective, and multicenter clinical trials are needed to confirm the efficacy and reliability of SVF in the treatment of scars.
Effectiveness of nurse‐led non‐pharmacological interventions on outcomes of delirium in adults: A meta‐analysis of randomized controlled trials
Authors: Wang Jiamin , Lu Yating , Chen Xiaohong , Wu Ying 
Published: August 2024

AbstractBackgroundDelirium is a common complication among adults. It is essential to improve the outcomes of delirium.AimTo systematically synthesize the evidence on the effectiveness of the nurse‐led non‐pharmacological interventions on outcomes of delirium in adults.MethodsElectronic databases including CINAHL, Cochrane Library, MEDLINE, EMBASE, PubMed, Web of Science, PsycINFO, and Clinical Trial Registration were searched comprehensively by the authors. The authors reviewed the full text and assessed the risk of bias using the Cochrane Risk of Bias Tool 2.0. The meta‐analysis was performed using RevMan and Stata software. The forest plots showed the overall effect of the included study and the I2 test was used to assess the degree of heterogeneity between studies. Random effects models were used to analyze studies with significant heterogeneity.ResultsA total of 32 studies (10,122 participants) were included in the meta‐analysis. Nurse‐led non‐pharmacological interventions resulted in a significantly lower incidence of delirium compared with the usual care/control group (risk ratio = 0.74, p < .001) and reduced mortality in the hospital compared with usual care (risk ratio = 0.81, p = .04). However, the implementation of nurse‐led, non‐pharmacological interventions had no significant effect on the duration, severity of delirium, or length of hospital stay.Linking Evidence to ActionOur findings suggest that the nurse‐led, non‐pharmacological strategy was effective in reducing the incidence of delirium and mortality in the hospital. Multicomponent interventions were the most effective strategy for reducing the incidence of delirium in adults.
Stochastic Modeling of Crack Growth and Maintenance Optimization for Metallic Components Subjected to Fatigue-Induced Failure
Authors: Zhang Xukai , Gulati Jasmine , Noshadravan Arash 
Published: August 2024

Abstract
The degradation of metallic systems under cyclic loading is subject to significant uncertainty, which affects the reliability of residual lifetime predictions and subsequent decisions on optimum maintenance schedules. This paper focuses two main challenges in developing a reliable framework for the lifecycle management of fatigue-critical components: constructing a stochastic model that captures uncertainties in crack growth histories, and presenting a computationally efficient strategy for solving the stochastic optimization associated with maintenance scheduling. Polynomial chaos (PC) representation is proposed to propagate uncertainty in the fatigue-induced crack growth process, using a database from constant amplitude loading experiments. Additionally, an optimization strategy is implemented based on Gaussian process surrogate modeling to solve the stochastic optimization problem under maximum probability of failure constraints. The sensitivity of the optimum solution to different probability of failure thresholds is examined. The proposed framework offers a decision support tool for informed decision-making under uncertainty, aiming to mitigate fatigue failure.
Experimental Method to Measure High-Temperature Hygroscopic Swelling in Epoxy Mold Compounds and Dielectric Build-Up Films
Authors: Chin Ian , Loh Wei Keat , Kee Seow Chien , He Yi , Abdullah Mohd. Zulkifly , Tsuriya Masahiro 
Published: August 2024

Abstract
In this study, high-temperature hygroscopic swelling characterization of different epoxy mold compounds (EMCs) and dielectric build-up films (DBFs) were analyzed using an experimental technique. The approach maintains specimens in a saturated state using a high-pressure enclosure, while digital image correlation (DIC) was used to measure in situ strain change in the specimen due to hygrothermal expansion. Hygroscopic swelling strain is obtained by removing the thermal strain component. This enables swelling characterization measurements above the temperature and humidity capability of typical commercial instruments. The results showed that moisture induced swelling is significant compared with thermal expansion and increases significantly with temperature above the glass transition temperature (Tg). EMCs were found to absorb more moisture and swell more compared to DBFs with comparable properties. The coefficient of hygroscopic swelling (CHS) for DBFs and EMCs was quite similarly low at low temperatures, but for EMCs, the CHS increased more at high temperatures. Results are compared against analytical solutions, other measurement methods, and published data.
Fluid Transient Analysis for Enhanced Performance of an Energy Recovery Device for a Small-Scale Reverse Osmosis Desalination Unit
Authors: Hassan Mohab A. , Wahba Essam M. , Adam Ihab G. , Swidan Mohamed A. 
Published: August 2024

Abstract
This article presents a comprehensive study of a double-acting cylinder (DAC) energy recovery device (ERD). The DAC was specifically designed, manufactured, and experimentally tested within a small-scale 5 m3/day brackish water reverse osmosis (RO) unit. The distinctive advantage of the DAC lies in its ability to operate without an extra booster pump, thereby reducing initial costs and streamlining system complexity. A comparative analysis was conducted between the station operating without any ERD and the station equipped with a DAC. For both scenarios, a parametric study was carried out to analyze the relationship between specific energy consumption (SEC) and recovery ratio at varying recovery percentages (10%, 15%, 20%, 25%, and 30%) for different salinity levels. This analysis was conducted across various feed flowrates, with the percentage reduction in SEC calculated for each case. The results show the DAC's ability to effectively reduce the SEC by up to 40%. Additionally, the study investigated brine-feed stream mixing within the DAC, highlighting its capability to prevent undesirable mixing despite internal leakage. However, its widespread adoption has been hindered by realizable pressure fluctuations associated with its implementation, which can lead to rapid fatigue failure. To address this issue, a direct-contact air vessel was integrated into the system to minimize pressure fluctuations and enhance the performance of the DAC. Its optimal size was determined through numerical analysis using the method of characteristics, with detailed design equations presented for future reference. The results affirm the indispensable function of the air vessel in attenuating unsteady effects.
Self-Reported Menstrual Health, Symptomatology, and Perceived Effects of the Menstrual Cycle for Elite Junior and Senior Football Players
Authors: Brown Georgia A. , Jones Mark , Cole Brandi , Shawdon Anik , Duffield Rob 
Published: August 2024

Purpose: To describe the self-reported menstrual health, symptomatology, and perceived effects of the menstrual cycle on athletic performance for national and international Australian football (soccer) players. Methods: Players from national and domestic teams were invited to complete an online questionnaire regarding menstrual health, use of hormonal contraceptives (HCs), negative symptomatology, and perceived disruption of the menstrual cycle to performance. Descriptive statistics and binomial regressions with odds ratios (OR) were used to report the relationship of menstrual-related variables with perceived performance disruption. Results: A total of 199 players (20.9 [5.1] y) completed the questionnaire, with 18% of players reporting using HCs. One primary amenorrhea case was detected, and 26% of players reported menarche at age ≥15 years. For non-HC users, the prevalence of secondary amenorrhea was 2%, oligomenorrhea was 19%, and heavy menstrual bleeding was 11%. Ninety-seven percent of players reported experiencing physical or affective menstrual symptoms (5 [1.3] per player), and 40% of all players reported that menstrual symptoms impacted their ability to work, study, train, or compete. Furthermore, 40% of players perceived their training or performance to be disrupted by the menstrual cycle. Increasing number of menstrual symptoms (OR = 1.43; 95% CI, 1.28–1.62; P < .001), heavy menstrual bleeding (OR = 12.73; 95% CI, 3.4–82.8; P < .001), and pelvic pain (OR = 3.40; 95% CI, 1.7–7.2; P < .001) increased the likelihood of perceiving the menstrual cycle to disrupt performance. Conclusion: Heavy menstrual bleeding and HC use were low among this cohort of national and international footballers, whereas amenorrhea and oligomenorrhoea were comparable with other football populations. Nearly all players reported menstrual symptoms, and increased symptomatology was associated with greater perceived effects on performance.
Genome sequences of three plastic-debris-inhabiting fungi isolated from New Zealand waste and recycling management plants
Authors: Palevich Nikola , Wu Shuyan , Li Yang , Palevich Faith P. , Maclean Paul H. , Singh Sidhu Jaspreet , Subharat Pornchanok , Jauregui Ruy , Müller Jana L. , Reilly Kerri , Mills John , Attwood Graeme T. , Brightwell Gale 
Published: August 2024

ABSTRACT

Cladosporium
and
Epicoccum
are cosmopolitan fungi of the class Dothideomycetes with few cultured and genomic representatives. Here, we report draft reference genome sequences of
Epicoccum
sp. F181 (GenBank accession number
JAJSLS01
),
Cladosporium
sp. F165 (
JAJSLR01
), and F190 (
JAJSLT01
) isolated from recycling and waste management facilities in New Zealand.
Vitreoretinal surgical performance after acute alcohol consumption and hangover
Authors: Roizenblatt Marina , Gehlbach Peter Louis , Marin Vitor Dias Gomes Barrios , Roizenblatt Arnaldo , Fidalgo Thiago Marques , Saraiva Vinicius Silveira , Nakanami Mauricio Hiroshi , Noia Luciana Cruz , Watanabe Sung , Yasaki Erika Sayuri , Passos Renato Magalhães , Magalhães Junior Octaviano , Fernandes Rodrigo Antonio Brant , Stefanini Francisco Rosa , Caiado Rafael , Jiramongkolchai Kim , Farah Michel Eid , Belfort Junior Rubens , Maia Mauricio 
Published: August 2024

Aim
Routine alcohol testing of practicing physicians remains controversial since there are no uniform guidelines or legal regulations in the medical field. Our aim was to quantitatively study the acute and next-morning effects of breath alcohol concentration (BAC)-adjusted alcohol intake on overall simulated surgical performance and microtremor among senior vitreoretinal surgeons.

Methods
This prospective cohort study included 11 vitreoretinal surgeons (>10 years practice). Surgical performance was first assessed using the Eyesi surgical simulator following same-day alcohol consumption producing a BAC reading of 0.06%–0.10% (low-dose), followed by 0.11%–0.15% (high-dose). Dexterity was then evaluated after a ‘night out’ producing a high-dose BAC combined with a night’s sleep. Changes in the total score (0–700, worst-best) and tremor (0–100, best-worst) were measured.

Results
Surgeon performance declined after high-dose alcohol compared with low-dose alcohol (−8.60±10.77 vs −1.21±7.71, p=0.04, respectively). The performance during hangover was similar to low-dose alcohol (−1.76±14.47 vs −1.21±7.71, p=1.00, respectively). The performance during hangover tended to be better than after high-dose alcohol (−1.76±14.47 vs −8.60±10.77, p=0.09, respectively). Tremor increased during hangover compared with low-dose alcohol (7.33±21.65 vs −10.31±10.73, p=0.03, respectively). A trend toward greater tremor during hangover occurred compared with high-dose alcohol (7.33±21.65 vs −4.12±17.17, p=0.08, respectively).

Conclusion
Alcohol-related decline in simulated surgical dexterity among senior vitreoretinal surgeons was dose-dependent. Dexterity improved the following morning but remained comparable to after low-dose alcohol ingestion. Tremor increased during hangover compared with same-day intoxication. Further studies are needed to investigate extrapolations of these data to a real surgical environment regarding patient safety and surgeon performance.
Effectiveness of a physiotherapy self-management programme for adult patients with chronic non-specific low back pain in low- and middle-income countries: protocol for a systematic review and meta-analysis
Authors: Motha Sergant Given , Naidoo Niri , Moyo-Chilufya Maureen , Musekiwa Alfred , Kgarosi Kabelo , Mostert Karien 
Published: August 2024

IntroductionChronic non-specific low back pain (CNLBP) is among the most common musculoskeletal system conditions reported worldwide; however, few studies are available from low- and middle-income countries (LMICs). Self-management is a set of tasks performed by the patient aiming at managing their symptoms and interference in activities, mood and relationships due to pain. A physiotherapy-guided self-management programme (SMP) following a biopsychosocial approach has been reported as effective and affordable in the management of CNLBP in high-income countries. The objective of this systematic review is to determine the overall effectiveness of SMPs for adults with CNLBP in LMICs.Methods and analysisIn this systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Protocol (PRISMA-P) guidelines will be followed. A three-step search strategy will be used to search the electronic databases (PubMed, MEDLINE, SPORTDiscus, Scopus and CINAHL, Academic Search Complete and PEDro) for randomised controlled trials assessing the effectiveness of physiotherapy-guided self-management for CNLBP among adult participants in LMICs. The processes of screening search results for eligible studies, extracting data from included studies and appraising will be done independently by at least two review authors. Random effects meta-analysis will be used to synthesise results and heterogeneity will be assessed using the I2test statistic and χ2test.Ethics and disseminationEthics clearance was obtained for the broader PhD study on the development of a physiotherapy-guided SMP for adult people with CNLBP in Limpopo Province, South Africa. The results of the manuscript for this protocol will be published in peer-reviewed journals and also presented at conferences, symposia, and congresses.PROSPERO registration numberCRD42023399572.
Systematic review and meta-analysis of postpartum depression and its associated factors among women before and after the COVID-19 pandemic in Uganda
Authors: Kabunga Amir , Tumwesigye Raymond , Kigongo Eustes , Musinguzi Marvin , Acup Walter , Auma Anna Grace 
Published: August 2024

ObjectiveThis meta-analysis aimed to estimate the national prevalence of postpartum depression (PPD) in Uganda and identify predictors in both pre-COVID-19 and post-COVID-19 eras.DesignUsed a systematic review and meta-analysis methodology.Data sourcesReviewed papers were sourced from Medline/PubMed, PsycINFO, CINAHL/EBSCOhost, Google Scholar, ScienceDirect and African Journals Online.Eligibility criteria for selected studiesThe review encompassed observational studies published on PPD in Uganda from 1 January 2000 to 30 November 2023.Results11 studies (involving 7564 participants) published from 1 January 2000 to 30 November 2023 were reviewed. The pooled prevalence of PPD in Uganda was 29% (95% CI 21% to 37%, I2=98.32%). Subgroup analysis indicated a similar prevalence before (29%, 95% CI 20% to 39%) and during (28%, 95% CI 22% to 32%) the COVID-19 period. Special groups exhibited a higher prevalence (32%, 95% CI 16% to 47%) than general postpartum women (28%, 95% CI 19% to 37%). Factors associated with PPD included poor social support (OR 1.19, 95% CI 1.17 to 1.22, I2=96.8%), maternal illness (OR 1.22, 95% CI 1.19 to 1.26, I2=96.9%), poor socioeconomic status (OR 1.43, 95% CI 1.40 to 1.46, I2=99.5%) and undergoing caesarean section (OR 1.15, 95% CI 1.12 to 1.17, I2=80.6%). Surprisingly, there was a marginal decrease in PPD during the COVID-19 period. Subgroup analysis highlighted a higher prevalence among mothers with HIV.ConclusionThis study underscores the significant prevalence of PPD in Uganda, with sociodemographic factors increasing risk. Despite a slight decrease during the COVID-19 period, the importance of prioritising maternal mental health is emphasised, considering sociodemographic factors and pandemic challenges, to improve maternal and child health outcomes and overall well-being.
Nordic inflammatory bowel disease treatment strategy trial: protocol for the NORDTREAT randomised controlled biomarker-strategy trial
Authors: Rejler Martin , Füchtbauer Johannes David , Davíðsdóttir Lóa G , Fejrskov Anja , Söderholm Johan D , Christensen Robin , Andersen Vibeke , Repsilber Dirk , Kjeldsen Jens , Høivik Marte , Halfvarson Jonas 
Published: August 2024

IntroductionThe absence of reliable prognostic markers poses a challenge to the management of inflammatory bowel disease (IBD). Patients with aggressive disease may not receive sufficient treatment with conventional ‘step-up’ therapy, whereas a top-down approach may expose patients with indolent disease to unnecessary treatment-related toxicity. The objective of the Nordic IBD treatment strategy trial (NORDTREAT) is to assess the feasibility of personalised therapy by stratifying patients according to a prognostic serum protein signature at diagnosis.Methods and analysisNORDTREAT is a multicentre, biomarker-strategy design, open-label controlled trial. After screening consent, eligible patients are randomised (1:1) into one of two groups: a group with access to the protein signature and a group without access. In the access to protein signature group, patients displaying a protein signature suggestive of an increased risk of an aggressive disease course will be treated in line with a top-down treatment algorithm (anti-tumour necrosis factor agent with/without an immunomodulator). In contrast, those with a protein signature indicative of indolent disease will be excluded from the trial. Patients not in the access group receive treatment based on clinical management. This traditional management involves a stepwise escalation of treatment as determined by the investigator after failure of first-line treatment. After 52 weeks, outcomes are assessed in the subgroup of patients with a protein profile indicating a potentially severe disease trajectory. The primary endpoint is a composite of the proportion of patients with corticosteroid-free clinical and endoscopic remission at week 52. Surgical intervention due to IBD during follow-up will be defined as treatment failure.Ethics and disseminationEthical approval has been obtained, and recruitment is underway at sites in four participating Nordic countries (Denmark, Iceland, Norway and Sweden). Following trial completion and data analysis, the trial results will be submitted for publication in peer-reviewed journals and presented at international conferences.Trial registration numberNCT05180175; Pre-results. EudraCT number: 2019-002942-19.