bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-invasive preimplantation genetic testing for aneuploidy: is the promise real?
Authors: Volovsky Michelle , Scott Richard T , Seli Emre 
Published: July 2024

Abstract
Recent advances in preimplantation genetic testing for aneuploidy (PGT-A) have significantly enhanced its application in ART, providing critical insights into embryo viability, and potentially reducing both the time spent in fertility treatments and the risk of pregnancy loss. With the integration of next-generation sequencing, PGT-A now offers greater diagnostic precision, although challenges related to segmental aneuploidies and mosaicism remain. The emergence of non-invasive PGT-A (niPGT-A), which analyzes DNA in spent embryo culture media, promises a simpler aneuploidy screening method. This mini review assesses the methodological criteria for test validation, the current landscape of PGT-A, and the potential of niPGT-A, while evaluating its advantages and potential pitfalls. It underscores the importance of a robust three-phase validation process to ensure the clinical reliability of PGT-A. Despite initial encouraging data, niPGT-A not only confronts issues of DNA amplification failure and diagnostic inaccuracies but also has yet to meet the three-prong criteria required for appropriate test validation, necessitating further research for its clinical adoption. The review underscores that niPGT-A, like traditional PGT-A, must attain the high standards of precision and reliability expected of any genetic testing platform used in clinical settings before it can be adopted into routine ART protocols.
Use of Upadacitinib as Salvage Therapy for Ulcerative Colitis in Pregnancy: A Case Report
Authors: Urquhart Siri A , Chedid Victor G , Kane Sunanda V 
Published: July 2024

Lay Summary
Upadacitinib, a selective JAK-1 inhibitor, was used as rescue therapy for ulcerative colitis in the setting of pregnancy following use of mesalamine, vedolizumab, infliximab, and corticosteroids. This resulted in an uncomplicated live full birth without need for surgical intervention.
Preparing the Next Generation of Integrative Organismal Biologists
Authors: Padilla Dianna K , Grünbaum Daniel 
Published: July 2024

Synopsis
Pursuing cutting edge questions in organismal biology in the future will require novel approaches for training the next generation of organismal biologists, including knowledge and use of systems-type modeling combined with integrative organismal biology. We link agendas recommending changes in science education and practice across three levels: Broadening the concept of organismal biology to promote modeling organisms as systems interacting with higher and lower organizational levels; enhancing undergraduate science education to improve applications of quantitative reasoning and modeling in the scientific process; and K-12 curricula based on Next Generation Science Standards emphasizing development and use of models in the context of explanatory science, solution design, and evaluating and communicating information. Out of each of these initiatives emerges an emphasis on routine use of models as tools for hypothesis testing and prediction. The question remains, however, what is the best approach for training the next generation of organismal biology students to facilitate their understanding and use of models? We address this question by proposing new ways of teaching and learning, including the development of interactive web-based modeling modules that lower barriers for scientists approaching this new way of imagining and conducting integrative organismal biology.
The impact of onset-to-cut time in surgery for stable acute type A aortic dissection—a single-centre retrospective cohort study
Authors: Pitts Leonard , Kofler Markus , Montagner Matteo , Heck Roland , Kurz Stephan Dominik , Paun Alexandru Claudiu , Falk Volkmar , Kempfert Jörg 
Published: July 2024

Abstract

OBJECTIVES
The goal of this study was to investigate the impact of onset-to-cut time on mortality in patients undergoing surgery for stable acute type A aortic dissection.

METHODS
Patients who underwent surgery for acute type A aortic dissection between January 2006 and December 2021 and available onset-to-cut times were included. Patients with unstable aortic dissection (preoperative shock, intubation, resuscitation, coma, pericardial tamponade and local/systemic malperfusion syndromes) were excluded. After descriptive analysis, a multivariable binary logistic regression for 30-day mortality was performed. A receiver operating characteristic curve for onset-to-cut time and 30-day mortality was calculated. Restricted cubic splines were designed to investigate the association between onset-to-cut time and survival.

RESULTS
The final cohort comprised 362 patients. The median onset-to-cut time was 543 (376–1155) min. The 30-day mortality was 9%. Only previous myocardial infarction (P = 0.018) and prolonged cardiopulmonary bypass time (P &lt; 0.001) were identified as independent risk factors for 30-day mortality. The corresponding area under the receiver operating characteristic curve showed a value of 0.49. Restricted cubic splines did not indicate an association between onset-to-cut time and survival (P = 0.316).

CONCLUSIONS
Onset-to-cut time in the setting of stable acute type A aortic dissection does not seem to be a valid predictor of 30-day mortality in patients undergoing surgery and stayed stable during the preoperative course.
FrameNet at 25
Authors: Boas Hans C , Ruppenhofer Josef , Baker Collin 
Published: July 2024

Abstract
The launch of the FrameNet project in 1997 was both a crystallisation point of decades worth of theoretical investigations into lexical meaning by Charles J. Fillmore and colleagues, as well as the seed of an ongoing line of corpus-based and computational research that seeks to implement Fillmore’s theory of Frame Semantics in a way that both provides an interesting model relevant for further theorising and also is applicable practically for semantic analysis, lexicology, and lexicography.
At the occasion of FrameNet’s 25th birthday, we want to introduce the project to a new generation of researchers but also take stock of, and report on, what has been achieved. We revisit the origins of the FrameNet project, assess its development and various changes in the years since it was first reported on in a special issue in the pages of this journal twenty years ago.
Will the real data sovereign please stand up? An EU policy response to sovereignty in data spaces
Authors: Ryan Mark , Gürtler Paula , Bogucki Artur 
Published: July 2024

Abstract
This paper aims to evaluate the concept of data sovereignty as applied to data spaces, particularly the Common European Data Space (CEDS). The CEDS aims to develop a single European data market through nine domain-specific data spaces: health, industrial and manufacturing, agriculture, finance, mobility, Green Deal, energy, public administration, and skills. It aims to do this by providing a secure and trustworthy technical architecture, a robust data-sharing business model realized through effective governance, and ensuring data sovereignty. Ensuring data sovereignty, however, is challenging when different agents all claim authority over their data within a data space. This paper focuses on three data sovereign agents in the CEDS—individual, organization, and state—to examine how data sovereignty can be implemented in data spaces based on current European Union regulations and whether shortcomings still need to be addressed.
Divergent Roles of APOAI and APOM in the Identification of Alcohol Use Disorder and Their Association With Inflammation and Cognitive Decline: A Pilot Study
Authors: Escudero Berta , López-Valencia Leticia , Arias Horcajadas Francisco , Orio Laura 
Published: July 2024

Abstract

Background
Alcohol use disorder (AUD) courses with inflammation and cognitive decline. Apolipoproteins have emerged as novel target compounds related to inflammatory processes and cognition.

Methods
A cross-sectional study was performed on abstinent AUD patients with at least 1 month of abstinence (n  = 33; 72.7% men) and healthy controls (n  = 34; 47.1% men). A battery of plasma apolipoproteins (APOAI, APOAII, APOB, APOCII, APOE, APOJ, and APOM), plasma inflammatory markers (LPS, LBP), and their influence on cognition and presence of the disorder were investigated.

Results
Higher levels of plasma APOAI, APOB, APOE, and APOJ, as well as the proinflammatory LPS, were observed in the AUD group, irrespective of sex, whereas APOM levels were lower vs controls. Hierarchical logistic regression analyses, adjusting for covariates (age, sex, education), associated APOM with the absence of cognitive impairment in AUD and identified APOAI and APOM as strong predictors of the presence or absence of the disorder, respectively. APOAI and APOM did not correlate with alcohol abuse variables or liver status markers, but they showed an opposite profile in their associations with LPS (positive for APOAI; negative for APOM) and cognition (negative for APOAI; positive for APOM) in the entire sample.

Conclusions
The HDL constituents APOAI and APOM were differentially regulated in the plasma of AUD patients compared with controls, playing divergent roles in the disorder identification and associations with inflammation and cognitive decline.
Phenotype divergence and cooperation in isogenic multicellularity and in cancer
Authors: Ernesto Alvarez Frank , Clairambault Jean 
Published: July 2024

Abstract
We discuss the mathematical modelling of two of the main mechanisms that pushed forward the emergence of multicellularity: phenotype divergence in cell differentiation and between-cell cooperation. In line with the atavistic theory of cancer, this disease being specific of multicellular animals, we set special emphasis on how both mechanisms appear to be reversed, however not totally impaired, rather hijacked, in tumour cell populations. Two settings are considered: the completely innovating, tinkering, situation of the emergence of multicellularity in the evolution of species, which we assume to be constrained by external pressure on the cell populations, and the completely planned—in the body plan—situation of the physiological construction of a developing multicellular animal from the zygote, or of bet hedging in tumours, assumed to be of clonal formation, although the body plan is largely—but not completely—lost in its constituting cells. We show how cancer impacts these two settings and we sketch mathematical models for them. We present here our contribution to the question at stake with a background from biology, from mathematics and from philosophy of science.
Barycentric rational interpolation of exponentially clustered poles
Authors: Zhao Kelong , Xiang Shuhuang 
Published: July 2024

Abstract
We have developed a rational interpolation method for analytic functions with branch point singularities, which utilizes several exponentially clustered poles proposed by Trefethen and his collaborators (2021, Exponential node clustering at singularities for rational approximation, quadrature, and PDEs. Numer. Math., 147, 227–254). The key to the feasibility of this interpolation method is that the interpolation nodes approximately satisfy the distribution of the equilibrium potential. These nodes make the convergence rate of the rational interpolation consistent with the theoretical rates, and steadily approach machine accuracy. The technique can be used, not only for the interval $[0,1]$, but can also be extended to include corner regions and the case of multiple singularities.
Frobenius Distributions of Low Dimensional Abelian Varieties Over Finite Fields
Authors: Arango-Piñeros Santiago , Bhamidipati Deewang , Sankar Soumya 
Published: July 2024

Abstract
Given a $g$-dimensional abelian variety $A$ over a finite field $\mathbf{F}_{q}$, the Weil conjectures imply that the normalized Frobenius eigenvalues generate a multiplicative group of rank at most $g$. The Pontryagin dual of this group is a compact abelian Lie group that controls the distribution of high powers of the Frobenius endomorphism. This group, which we call the Serre–Frobenius group, encodes the possible multiplicative relations between the Frobenius eigenvalues. In this article, we classify all possible Serre–Frobenius groups that occur for $g \le 3$. We also give a partial classification for simple ordinary abelian varieties of prime dimension $g\geq 3$.
Phase 3 Study Assessing Lot-to-Lot Consistency of Respiratory Syncytial Virus Prefusion Protein F3 Vaccine and Its Immune Response, Safety, and Reactogenicity When Co-administered With Quadrivalent Influenza Vaccine
Authors: Chime Nnenna , Anspach Bruno , Jain Vishal , Laajalahti Outi , Ollinger Thierry , Yaplee Deborah , Kim Joon Hyung 
Published: July 2024

Abstract

Background
A single-dose investigational respiratory syncytial virus (RSV) vaccine, RSV prefusion protein F3 (RSVPreF3), was co-administered with a single-dose quadrivalent influenza vaccine (FLU-D-QIV) in a phase 3, randomized, controlled, multicenter study in healthy, nonpregnant women aged 18–49 years.

Methods
The study was observer-blind to evaluate the lot-to-lot consistency of RSVPreF3, and single-blind to evaluate the immune response, safety, and reactogenicity of RSVPreF3 co-administered with FLU-D-QIV.

Results
A total of 1415 participants were included in the per-protocol set. There was a robust immune response at day 31 across each of the 3 RSVPreF3 vaccine lots; adjusted geometric mean concentration ratios (95% confidence interval [CI]) were 1.01 (.91–1.12), 0.93 (.84–1.03), and 0.92 (.83–1.02) for RSV1/RSV2, RSV1/RSV3, and RSV2/RSV3, respectively. For FLU-D-QIV co-administered with RSVPreF3, versus FLU-D-QIV alone at day 31, noninferiority was satisfied for 3 of 4 strains assessed, with the lower limit of the 95% CI for geometric mean ratio &gt;0.67.

Conclusions
Immunogenic consistency was demonstrated for 3 separate lots of RSVPreF3. Immunogenic noninferiority was demonstrated when comparing FLU-D-QIV administered alone, versus co-administered with RSVPreF3, for 3 strains of FLU-D-QIV. Co-administration was well tolerated, and both vaccines had clinically acceptable safety and reactogenicity profiles.

Clinical Trials Registration
NCT05045144; EudraCT 2021-000357-26.
Historical Immigration Policies: Trends and Lessons
Authors: Peters Margaret E , Boräng Frida , Kalm Sara , Lindvall Johannes , Shin Adrian J 
Published: July 2024

Abstract
In recent years, scholars of migration have created several new immigration policy indexes, but most existing databases have limited temporal scope. They also focus, to a large extent, on the Global North. In this research note, we introduce the Historical Immigration Policy dataset (HIP), which begins to fill these gaps. We first provide an overview of the data and then describe how they offer new insights into immigration policy. We make three empirical observations. (1) On average, democracies are less open to immigration than authoritarian states but grant resident migrants more rights. (2) European states were open to immigration earlier than standard accounts of global migration assume. (3) Historically, openness to immigration and inclusive rights for resident migrants have often been complements, not substitutes.
Audience Costs and the Credibility of Public versus Private Threats in International Crises
Authors: Takei Makito 
Published: July 2024

Abstract
The credibility of public versus private threats in international crisis bargaining has received scholarly attention. While public threats are often believed to be more credible than private ones because of audience costs, others contend that private threats should be equally credible or even more. Also, the effect of public threats can be conditioned by other domestic factors such as domestic hawkishness and a leader’s unpopularity. To test these competing expectations, I conducted a conjoint survey experiment that examines how observers assess resolve to fight in an international crisis with a sample of US citizens (N = 1,203). Three major findings stand out. First, evidence suggests that both types of threats increase the perceived likelihood that a country will stand firm. Second, though their effect size is small, public threats are more effective than private ones. Lastly, I find support for the conditional effect of public threats, indicating that the underlying mechanism of the credibility of public threats is domestic audience costs.
Gender Wars? Diplomacy as a Depolarizing Practice in International Politics of Gender and Sexuality
Authors: de Silva Monika 
Published: July 2024

Abstracts
To what extent is diplomacy a depolarizing tool of international society? This article proposes a novel theoretical and empirical focus on depolarization in international politics of gender and sexuality. It operationalizes the concepts of polarization and depolarization and integrates them with Self/Other theory in international relations. It puts forward an argument that the logic of diplomacy is, although not unequivocally, compatible with the logic of depolarization. The claim and the application of the framework are illustrated with a case study of gender equality and LGBT+ rights diplomacies in Poland. Based on the empirical findings, the article contends that diplomacy is primarily a practice of depolarization.
Promoting Law Beyond the State
Authors: Swenson Geoffrey 
Published: July 2024

Abstracts
In countries receiving foreign aid, non-state justice systems rooted in custom or religion generally handle most legal disputes. This dramatically influences the prospects of international efforts to promote the rule of law, yet scholars have paid little attention to foreign policy toward non-state justice. This paper explores how the nine largest rule-of-law-assistance providers engaged non-state justice between 2008 and 2018, illuminating the theory behind, and the reality of, donor-state policy. It proposes a new classificatory typology of donor approaches to non-state justice detailing five strategies (denial, acknowledgment, acceptance, transformation, and rejection) and four goals (judicial reform, symbolic recognition, state-building, and counterinsurgency). It then explores how the nine largest rule-of-law-assistance donor states addressed non-state justice through a structured comparison of policy documents as well as case studies of the five donors with the most comprehensive approaches. Donors strongly favored risk-averse approaches, even when this made success unlikely. Certain policy goals—such as state-building or counterinsurgency—sometimes prompted riskier choices, but only with a compelling justification and a reasonable prospect of success. Overall, major rule-of-law donors displayed risk-averse, superficial policy, minimal stakeholder engagement, a failure to grapple with the nuances of legal pluralism, and a lack of evidence to support existing policies.
Disagreement in Aesthetics and Ethics: Against the Received Image
Authors: Guerreiro Vítor , Cadilha Susana 
Published: July 2024

Abstract
The way we think about disagreement is shaped by the systematic emphasizing of its adversarial, non-cooperative aspects. This is due to a perspective on arguing and disagreeing. Perspectives enable some thoughts and occlude others. We claim that the way some issues are thought of in aesthetics is conditioned by a similar phenomenon we call ‘the Received Image’ (RI), which parallels the influence on ethics of what Bernard Williams called ‘systems of morality’. Peter Kivy argued that disagreements in aesthetics, if genuine, presuppose that contenders are tacit realists about ‘art-relevant properties’: the motivation for arguing lies in making the adversary acknowledge (epistemic) defeat (in pursuing agreement from others). He draws this conclusion from what he sees as a fundamental difference between aesthetics and ethics. However, in our view, Kivy and his opponents in the semantic meta-debate on disagreement think under the aegis of the RI. We look at disagreements about art from a neo-cognitivist perspective, and argue that heuristic similarities between aesthetics and ethics stand out with an understanding-based epistemology coupled with an adequate theory of artistic form: form as a perspective-generating device whose grasping involves ‘infinitely fine adjustments’.
Check of APpropriaTeness of Antimicrobial therapy In Nursing homes (CAPTAIN):a point prevalence study in Belgium
Authors: Coenen Indira , Vander Elst Lotte , Spriet Isabel , Gijsen Matthias , Foulon Veerle , De Lepeleire Jan , Latour Katrien , Cossey Veerle , Schuermans Annette , Stroobants Nele , Quintens Charlotte 
Published: July 2024

Abstract

Objectives
The overall prevalence of antimicrobial therapy (AMT) in nursing homes is well described. However, less is known about the appropriateness of AMT in nursing home residents. Therefore, the Check of APpropriaTeness of antimicrobial therapy in nursing homes (CAPTAIN) study aimed to assess both prevalence and appropriateness of AMT in Belgian nursing homes.

Methods
In a prospective, observational, point prevalence study, researchers documented prevalence and identified potentially inappropriate prescriptions (PIPs) by evaluating accordance of AMT with national guidelines. The severity of inappropriateness was assessed by a modified Delphi expert panel.

Results
Eleven nursing homes, including 1178 residents, participated in this study. On the survey day, 8.0% of residents took systemic AMT, primarily for urinary tract infections (54.2%), respiratory tract infections (36.5%), and skin and skin-structure infections (6.3%). About half of these prescriptions were used in prophylaxis (52.1%). Registration of indication and stop date was missing in 58.3% and 56.3% of AMTs, respectively. In 89.6% of the systemic AMTs, at least one discordance with national guidelines was identified, resulting in a total of 171 PIPs, with 49 unique PIPs. Of all unique PIPs, 26.5% were assessed with a high severity score (≥4). According to the expert panel, most inappropriate practice was starting AMT for cough without other symptoms. Inappropriate timing of time-dependent AMTs was common, but assessed as ‘moderately severe’. One-third of systemic AMT exceeded the recommended duration.

Conclusions
AMT in nursing homes is often not prescribed according to national guidelines, highlighting the need for future interventions to promote the rational use of AMT in this setting.
“Covering provider”: an effort to streamline clinical communication chaos
Authors: Joshi Mugdha , Gokhale Arjun , Ma Stephen , Pendrey Anna , Wozniak Lauren , Moturu Anoosha , Schwartz Nicholas U , Wilson Austin , Darmawan Kelly , Phillips Brian , Cullum Stav , Sharp Christopher , Brown Gretchen , Shieh Lisa , Schmiesing Clifford 
Published: July 2024

Abstract

Objective
This report describes a root cause analysis of incorrect provider assignments and a standardized workflow developed to improve the clarity and accuracy of provider assignments.

Materials and Methods
A multidisciplinary working group involving housestaff was assembled. Key drivers were identified using value stream mapping and fishbone analysis. A report was developed to allow for the analysis of correct provider assignments. A standardized workflow was created and piloted with a single service line. Pre- and post-pilot surveys were administered to nursing staff and participating housestaff on the unit.

Results
Four key drivers were identified. A standardized workflow was created with an exclusive treatment team role in Epic held by a single provider at any given time, with a corresponding patient list column displaying provider information for each patient. Pre- and post-survey responses report decreased confusion, decreased provider identification errors, and increased user satisfaction among RNs and residents with sustained uptake over time.

Conclusion
This work demonstrates structured root cause analysis, notably engaging housestaff, to develop a standardized workflow for an understudied and growing problem. The development of tools and strategies to address the widespread burdens resulting from clinical communication failures is needed.