bluuebunny/crossref_metadata_2025_split huggingface dataset:
KIS, a target of SOX4, regulates the ID1-mediated enhancement of β-catenin to facilitate lung adenocarcinoma cell proliferation and metastasis
Authors: Chang Jing-Xia , Zhang Meng , Lou Li-Li , Chu He-Ying , Wang Hua-Qi 
Published: July 2024

Abstract
Purpose
Kinase interacting with stathmin (KIS) is a serine/threonine kinase involved in RNA processing and protein phosphorylation. Increasing evidence has suggested its involvement in cancer progression. The aim of this study was to investigate the role of KIS in the development of lung adenocarcinoma (LUAD). Dual luciferase assay was used to explore the relationship between KIS and SOX4, and its effect on ID1/β-catenin pathway.

Methods
Real-time qPCR and western blot were used to assess the levels of KIS and other factors. Cell proliferation, migration, and invasion were monitored, and xenograft animal model were established to investigate the biological functions of KIS in vitro and in vivo.

Results
In the present study, KIS was found to be highly expressed in LUAD tissues and cell lines. KIS accelerated the proliferative, migratory and invasive abilities of LUAD cells in vitro, and promoted the growth of LUAD in a mouse tumor xenograft model in vivo. Mechanistically, KIS activated the β-catenin signaling pathway by modulating the inhibitor of DNA binding 1 (ID1) and was transcriptionally regulated by SOX4 in LUAD cells.

Conclusion
KIS, a target of SOX4, regulates the ID1-mediated enhancement of β-catenin to facilitate LUAD cell invasion and metastasis.
MASCC/ISOO Clinical Practice Statement: The risk of secondary oral cancer following hematopoietic cell transplantation
Authors: Raber-Durlacher Judith E. , Treister Nathaniel S. , Zadik Yehuda , Dean David R. , Miranda-Silva Wanessa , Fregnani Eduardo R. , Epstein Joel B. , Elad Sharon 
Published: July 2024

Abstract
Purpose
A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise tool for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS is focused on the risk of secondary oral cancer following hematopoietic cell transplantation (HCT).

Methods
This CPS was developed based on critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of the Oral Care Study Group of MASCC/ISOO. The information is presented in the form of succinct bullets to generate a short manual about the best standard of care.

Results
Studies described a 7–16-fold higher risk of secondary oral cancer (mainly squamous cell carcinoma) in allogeneic HCT (alloHCT) recipients, particularly in those who developed chronic graft versus host disease (cGVHD). Risk increases over time and is influenced by several risk factors. In autologous HCT, oral cancer risk seemed only slightly elevated.

Conclusion
Clinicians should be aware of the higher oral cancer risk in alloHCT survivors, and emphasize the importance of lifelong oral cancer surveillance (at least every 6–12 months) and avoiding cancer promoting lifestyle factors in an empathic way, particularly of those with (a history of) cGVHD. Post-HCT for Fanconi anemia or dyskeratosis congenita, education and rigorous follow-up is even more crucial. In case of suspected oral lesions in the presence of oral mucosal cGVHD, a GVHD intervention may facilitate diagnosis. Suspected lesions should be biopsied. More research is needed on the role of HPV in oral cancer post-HCT.
Bone marrow aspirate and bone marrow aspirate concentrate: Does the literature support use in long-bone nonunion and provide new insights into mechanism of action?
Authors: Moyal Andrew J. , Li Austin W. , Adelstein Jeremy M. , Moon Tyler J. , Napora Joshua K. 
Published: July 2024

Abstract
Purpose
To assess the use of bone marrow aspirate (BM) and bone marrow aspirate concentrate (BMAC) in the treatment of long-bone nonunion and to understand mechanism of action.

Methods
A systematic review of PubMed and EBSCOHost was completed to identify studies that investigated the use of BM or BMAC for the diagnosis of delayed union and/or nonunion of long-bone fractures. Studies of isolated bone marrow-mesenchymal stem cells (BM-MSCs) and use in non-long-bone fractures were excluded. Statistical analysis was confounded by heterogeneous fracture fixation methods, treatment history, and scaffold use.

Results
Our initial search yielded 430 publications, which was screened down to 25 studies. Successful treatment in aseptic nonunion was reported at 79–100% (BM) and 50–100% (BMAC). Septic nonunion rates were slightly better at 73–100% (BM) and 83.3–100% (BMAC). 18/24 studies report union rates > 80%. One study reports successful treatment of septic nonunion with BMAC and no antibiotics. A separate study reported a significant reduction in autograft reinfection rate when combined with BMAC (P = 0.009). Major adverse events include two deep infections at injection site and one case of heterotopic ossification. Most studies note transient mild donor site discomfort and potential injection site discomfort attributed to needle size.

Conclusion
The current literature pertaining to use of BM/BMAC for nonunion is extremely heterogeneous in terms of patient population and concomitant treatment modalities. While results are promising for use of BM/BMAC with other gold standard treatment methodologies, the literature requires additional Level I data to clarify the impact of role BM/BMAC in treating nonunion when used alone and in combination with other modalities.

Level of evidence
Level III.
Thermo-mechanical investigation of a friction oscillator under high-frequency excitation
Authors: Keller Simon , Fidlin Alexander 
Published: July 2024

AbstractThe frictional behavior, temperature evolution, and system dynamics in tribological systems are closely coupled. However, in many cases, at least one of the mentioned phenomena is neglected or not modeled consistently. This paper presents a model of a thermo-mechanically coupled oscillator, where the reduction of friction force due to high-frequency excitation is analyzed. The oscillator’s equation of motion, the impulse balance, and the heat equation for the thermo-mechanical continuum are evaluated so that a set of nonlinear equations describes the coupled system. Using specific mathematical procedures like Laplace-transformation and a particular transformation ansatz for integral equations, the system can be transformed into a set of ordinary differential equations, enabling efficient simulation. Based on this equation set, an averaging method is applied to eliminate the fast time scale of the mechanical oscillation due to high-frequency excitation so that only the averaged influence of the motion goes into the heat evolution. This procedure leads to concise expressions to determine the stationary state of the system, and the quantities of interest can be calculated conveniently. These equations yield parameter combinations where the friction force can be reduced due to the high-frequency excitation, even though thermal expansion is considered. However, there are also parameter regions where the excitation yields a significantly larger friction force.
Investigating the relationship between physical cognitive tasks and a social cognitive task in a wild bird
Authors: Blackburn Grace , Ashton Benjamin J. , Thornton Alex , Hunter Holly , Woodiss-Field Sarah , Ridley Amanda R. 
Published: July 2024

Abstract
Despite considerable research into the structure of cognition in non-human animal species, there is still much debate as to whether animal cognition is organised as a series of discrete domains or an overarching general cognitive factor. In humans, the existence of general intelligence is widely accepted, but less work has been undertaken in animal psychometrics to address this question. The relatively few studies on non-primate animal species that do investigate the structure of cognition rarely include tasks assessing social cognition and focus instead on physical cognitive tasks. In this study, we tested 36 wild Western Australian magpies (Gymnorhina tibicen dorsalis) on a battery of three physical (associative learning, spatial memory, and numerical assessment) and one social (observational spatial memory) cognitive task, to investigate if cognition in this species fits a general cognitive factor model, or instead one of separate physical and social cognitive domains. A principal component analysis (PCA) identified two principal components with eigenvalues exceeding 1; a first component onto which all three physical tasks loaded strongly and positively, and a second component onto which only the social task (observational spatial memory) loaded strongly and positively. These findings provide tentative evidence for separate physical and social cognitive domains in this species, and highlight the importance of including tasks assessing both social and physical cognition in cognitive test batteries.
Thermal insulation does not hamper assessment of injuries in trauma CT scans
Authors: Sanak Tomasz , Skowronek Aleksandra , Mendrala Konrad , Darocha Tomasz , Liszka Grzegorz , Chrzan Robert , Woźniak Krzysztof Jerzy , Staskiewicz Grzegorz , Podsiadło Paweł 
Published: July 2024

Abstract
Purpose
The use of thermal insulations reduces the risk of hypothermia, therefore decreases the risk of death in trauma victims. The aim of the study was to assess whether thermal insulations cause artifacts, which may hinder the diagnosis of injuries, and how the used thermo-systems alter the radiation dose in polytrauma computed tomography.

Methods
Computed tomography scans were made using the road accident victim body wrapped consecutively with 7 different covers. 14 injury areas were listed and evaluated by 22 radiologists. The radiation dose was measured using a dosimeter placed on the victim in the abdominal area.

Results
No significant artifacts in any of the tested covers were observed. The presence of few minor artifacts did not hinder the assessment of injuries. Certain materials increased (up to 19,1%) and some decreased (up to -30,3%) the absorbed radiation dose.

Conclusions
Thermal insulation systems tested in this study do not cause significant artifacts hindering assessment of injuries in CT scans. Concern for artifacts and increased radiation dose should not be a reason to remove patients’ thermal insulation during performing trauma CT-scanning.
Multiple craniotomies in patients with brain metastases: a two-center, propensity score-matched study
Authors: Padevit Luis , Zeitlberger Anna Maria , Maldaner Nicolai , Sarnthein Johannes , Bozinov Oliver , Regli Luca , Neidert Marian Christoph , Serra Carlo , Voglis Stefanos 
Published: July 2024

AbstractThe current study addresses the question of whether the resection of more than one BM by multiple craniotomies within the same operation is associated with more adverse events (AEs) and worse functional outcome compared to cases in which only one BM was resected. All patients who underwent more than one craniotomy for resection of multiple BM at two Swiss tertiary neurosurgical care centers were included. Any AEs, functional outcome, and overall survival (OS) were analyzed after 1:1 propensity score matching with patients who underwent removal of a single BM only. A total of 94 patients were included in the final study cohort (47 of whom underwent multiple craniotomies). There was no significant difference in the incidence of AEs between the single and the multiple craniotomy group (n = 2 (4.3%) vs. n = 4 (8.5%), p = .7). Change in modified Rankin Scale (mRS) and Karnofsky Performance Status (KPS) at discharge demonstrated that slightly more single craniotomy patients improved in mRS, while the proportion of patients who worsened in mRS (16.3 vs. 16.7%) and KPS (13.6 vs. 15.2%) was similar in both groups (p = .42 for mRS and p = .92 for KPS). Survival analysis showed no significant differences in OS between patients with single and multiple craniotomies (p = .18). Resection of multiple BM with more than one craniotomy may be considered a safe option without increased AEs or worse functional outcome.
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
Authors: Pang Boxian , Dong Guangtong , Pang Tieliang , Sun Xinyao , Liu Xin , Nie Yifeng , Chang Xing 
Published: July 2024

AbstractAs a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by residing between circulating blood and semi-solid tissue. Various stress stimuli can induce endothelial injury, leading to the onset of corresponding diseases in the body. In recent years, the importance of mitochondria in vascular endothelial injury has become increasingly apparent. Mitochondria, as the primary site of cellular aerobic respiration and the organelle for “energy information transfer,” can detect endothelial cell damage by integrating and receiving various external stress signals. The generation of reactive oxygen species (ROS) and mitochondrial dysfunction often determine the evolution of endothelial cell injury towards necrosis or apoptosis. Therefore, mitochondria are closely associated with endothelial cell function, helping to determine the progression of clinical diseases. This article comprehensively reviews the interconnection and pathogenesis of mitochondrial-induced vascular endothelial cell injury in cardiovascular diseases, renal diseases, pulmonary-related diseases, cerebrovascular diseases, and microvascular diseases associated with diabetes. Corresponding therapeutic approaches are also provided. Additionally, strategies for using clinical drugs to treat vascular endothelial injury-based diseases are discussed, aiming to offer new insights and treatment options for the clinical diagnosis of related vascular injuries.
AI’s effect on innovation capacity in the context of industry 5.0: a scoping review
Authors: Bécue Adrien , Gama Joao , Brito Pedro Quelhas 
Published: July 2024

AbstractThe classic literature about innovation conveys innovation strategy the leading and starting role to generate business growth due to technology development and more effective managerial practices. The advent of Artificial Intelligence (AI) however reverts this paradigm in the context of Industry 5.0. The focus is moving from “how innovation fosters AI” to “how AI fosters innovation”. Therefore, our research question can be stated as follows: What factors influence the effect of AI on Innovation Capacity in the context of Industry 5.0? To address this question we conduct a scoping review of a vast body of literature spanning engineering, human sciences, and management science. We conduct a keyword-based literature search completed by bibliographic analysis, then classify the resulting 333 works into 3 classes and 15 clusters which we critically analyze. We extract 3 hypotheses setting associations between 4 factors: company age, AI maturity, manufacturing strategy, and innovation capacity. The review uncovers several debates and research gaps left unsolved by the existing literature. In particular, it raises the debate whether the Industry5.0 promise can be achieved while Artificial General Intelligence (AGI) remains out of reach. It explores diverging possible futures driven toward social manufacturing or mass customization. Finally, it discusses alternative AI policies and their incidence on open and internal innovation. We conclude that the effect of AI on innovation capacity can be synergic, deceptive, or substitutive depending on the alignment of the uncovered factors. Moreover, we identify a set of 12 indicators enabling us to measure these factors to predict AI’s effect on innovation capacity. These findings provide researchers with a new understanding of the interplay between artificial intelligence and human intelligence. They provide practitioners with decision metrics for a successful transition to Industry 5.0.
Non-compliance as a determinant of constitutional change? A comparative study
Authors: Schnelle Tim 
Published: July 2024

AbstractIt has often been claimed that if constitutions are not complied with, they will be changed. Because an ineffective constitutional contract is a bad contract, a lack of enforcement should induce constitutional reform. This paper empirically tests this conjecture based on a dataset of 170 countries from 1950 to 2018. The results indicate that the size of the de jure/de facto gap has no effect on the likelihood of constitutional change as such. However, after differentiating between amendments and replacements as distinct modes of constitutional reform, the results imply that non-compliance robustly increases the probability of constitutional replacement only. This relationship is primarily driven by an implementation gap regarding political and civil rights. Expected moderating effects of interpersonal trust and civil society organizations as catalysts for successful civil reform movements cannot be empirically supported. Overall, this has important consequences for the writers of future constitutions. If reformers desire longevity for their new constitutional framework, they must be aware that utopian promises may backfire by provoking a quick replacement of their rules.
Evaluating measurement invariance of students’ practices regarding online information questionnaire in PISA 2022: a comparative study using MGCFA and alignment method
Authors: Sözer Boz Esra 
Published: July 2024

Abstract
International large-scale assessments provide cross-national data on students’ cognitive and non-cognitive characteristics. A critical methodological issue that often arises in comparing data from cross-national studies is ensuring measurement invariance, indicating that the construct under investigation is the same across the compared groups. This study addresses the measurement invariance of students’ practices regarding online information (ICTINFO) questionnaire across countries in the PISA 2022 cycle. Some methodological complexities have arisen when testing the measurement invariance across the presence of many groups. For testing measurement invariance, the multiple group confirmatory factor analysis (MGCFA), which is a traditional procedure, was employed first, and then a novel approach, the alignment method, was performed. This study comprised 29 OECD countries, with a total sample size of 187.614 15-year-old students. The MGCFA results revealed that metric invariance was achieved across countries, indicating comparable factor loadings while not the same for factor means. Consistent with MGCFA results, the alignment method identified noninvariant parameters exceeding the 25% cut-off criteria across countries. Monte Carlo simulation validated the reliability of the alignment results. This study contributes to international assessments by providing a detailed examination of measurement invariance and comparing the findings from various methodologies for improving assessment accuracy. The results provide evidence-based recommendations for policymakers to ensure fair and equitable evaluations of student performance across different countries, thereby contributing to more reliable and valid international assessments.
Low-temperature fabrication of morphology-controllable Cu2O for electrochemical CO2 reduction
Authors: Dahal Rabin , Ray Schindra Kumar , Pathiraja Gayani , Bastakoti Bishnu Prasad 
Published: July 2024

AbstractCu2O has been successfully synthesized in different morphologies/sizes (nanoparticles and octahedrons) via a low-temperature chemical reduction method. Trapping metal ions in an ice cube and letting them slowly melt in a reducing agent solution is the simplest way to control the nanostructure. Enhancement of charge transfer and transportation of ions by Cu2O nanoparticles was shown by cyclic voltammetry and electrochemical impedance spectroscopy measurements. In addition, nanoparticles exhibited higher current densities, the lowest onset potential, and the Tafel slope than others. The Cu2O electrocatalyst (nanoparticles) demonstrated the Faraday efficiencies (FEs) of CO, CH4, and C2H6 up to 11.90, 76.61, and 1.87%, respectively, at −0.30 V versus reference hydrogen electrode, which was relatively higher FEs than other morphologies/sizes. It is mainly attributed to nano-sized, more active sites and oxygen vacancy. In addition, it demonstrated stability over 11 h without any decay of current density. The mechanism related to morphology tuning and electrochemical CO2 reduction reaction was explained. This work provides a possible way to fabricate the different morphologies/sizes of Cu2O at low-temperature chemical reduction methods for obtaining the CO, CH4, and C2H6 products from CO2
Maximal Codimension Collisions and Invariant Measures for Hard Spheres on a Line
Authors: Wilkinson Mark 
Published: July 2024

AbstractFor any $$N\ge 3$$

N
≥
3

, we study invariant measures of the dynamics of N hard spheres whose centres are constrained to lie on a line. In particular, we study the invariant submanifold $$\mathcal {M}$$
M
of the tangent bundle of the hard sphere billiard table comprising initial data that lead to the simultaneous collision of all N hard spheres. Firstly, we obtain a characterisation of those continuously-differentiable N-body scattering maps which generate a billiard dynamics on $$\mathcal {M}$$
M
admitting a canonical weighted Hausdorff measure on $$\mathcal {M}$$
M
(that we term the Liouville measure on$$\mathcal {M}$$
M
) as an invariant measure. We do this by deriving a second boundary-value problem for a fully nonlinear PDE that all such scattering maps satisfy by necessity. Secondly, by solving a family of functional equations, we find sufficient conditions on measures which are absolutely continuous with respect to the Hausdorff measure in order that they be invariant for billiard flows that conserve momentum and energy. Finally, we show that the unique momentum- and energy-conserving linearN-body scattering map yields a billiard dynamics which admits the Liouville measure on $$\mathcal {M}$$
M
as an invariant measure.
Limited memory gradient methods for unconstrained optimization
Authors: Ferrandi Giulia , Hochstenbach Michiel E. 
Published: July 2024

AbstractThe limited memory steepest descent method (LMSD, Fletcher, 2012) for unconstrained optimization problems stores a few past gradients to compute multiple stepsizes at once. We review this method and propose new variants. For strictly convex quadratic objective functions, we study the numerical behavior of different techniques to compute new stepsizes. In particular, we introduce a method to improve the use of harmonic Ritz values. We also show the existence of a secant condition associated with LMSD, where the approximating Hessian is projected onto a low-dimensional space. In the general nonlinear case, we propose two new alternatives to Fletcher’s method: first, the addition of symmetry constraints to the secant condition valid for the quadratic case; second, a perturbation of the last differences between consecutive gradients, to satisfy multiple secant equations simultaneously. We show that Fletcher’s method can also be interpreted from this viewpoint.