bluuebunny/crossref_metadata_2025_split huggingface dataset:
MINIstock: Model for INsect Inclusion in sustainable agriculture: USDA-ARS’s research approach to advancing insect meal development and inclusion in animal diets
Authors: Robinson Kelsy , Duffield Kristin R , Ramirez José L , Cohnstaedt Lee W , Ashworth Amanda , Jesudhasan Palmy R , Arsi Komala , Morales Ramos Juan A , Rojas M Guadalupe , Crippen Tawni L , Shanmugasundaram Revathi , Vaughan Martha , Webster Carl , Sealey Wendy , Purswell Joseph L , Oppert Brenda , Neven Lisa , Cook Kim , Donoghue Annie M 
Published: July 2024

Abstract
Animal agriculture is under pressure to increase efficiency, sustainability, and innovation to meet the demands of a rising global population while decreasing adverse environmental effects. Feed cost and availability are 2 of the biggest hurdles to sustainable production. Current diets depend on sources of grain and animal byproduct protein for essential amino acids which have limited sustainability. Insects have arisen as an attractive, sustainable alternative protein source for animal diets due to their favorable nutrient composition, low space and water requirements, and natural role in animal diets. Additionally, insects are capable of bioremediating waste streams including agricultural and food waste, manure, and plastics helping to increase their sustainability. The insect rearing industry has grown rapidly in recent years and shows great economic potential. However, state-of-the-art research is urgently needed to overcome barriers to adoption in commercial animal diets such as regulatory restrictions, production scale issues, and food safety concerns. To address this need, the USDA Agricultural Research Service “MINIstoc: Model for INsect Inclusion” project was created to bring together diverse scientists from across the world to synergistically advance insect meal production and inclusion in animal diets. Here, we provide a short review of insects as feed while describing the MINIstock project which serves as the inspiration for the Journal of Economic Entomology Special Collection “Insects as feed: sustainable solutions for food waste and animal production practices.”
Comprehensive analysis of distinct circadian clock subtypes of adult diffuse glioma and their associations with clinicopathological, genetic, and epigenetic profiles
Authors: Le Minh-Khang , Tran Nguyen Quoc Vuong , Nguyen Phuc-Tan , Nguyen Thuy-An , Nakao Atsuhito , Kondo Tetsuo 
Published: July 2024

Abstract
The circadian clock (CC) has biological and clinical implications in gliomas. Most studies focused on CC effects on the tumor microenvironment and the application of chronotherapy. The present study focused on CC gene expression patterns and intracellular oncogenic activities. Glioma gene expression data were collected from The Human Cancer Genome Atlas (TCGA) project. After applying inclusion and exclusion criteria, we selected 666 patients from TCGA-GBM and TCGA-LGG projects and included important clinicopathological variables. The entire cohort was subjected to clustering analysis and divided into CC1 and CC2 subtypes based on statistical, biological, and clinical criteria. CC2 gliomas showed higher expression of BMAL1 and CRY1 and lower expression of CRY2 and PER2 (adjusted P &lt; .001). CC2 gliomas had q higher activity of cell proliferation, metabolic reprogramming, angiogenesis, hypoxia, and many oncogenic signals (P &lt; .001). The CC2 subtype contained a higher proportion of glioblastomas (P &lt; .001) and had a worse prognosis (P &lt; .001). Stratified Kaplan–Meier and multivariable Cox analyses illustrated that the CC subtype is an independent prognostic factor to clinicopathological characteristics (P &lt; .001), genetic aberrations (P = .006), and biological processes (P &lt; .001). Thus, this study shows statistical evidence of CC subtypes and their biological, and clinicopathological significance in adult gliomas.
The ingenious drainage system controls persistent duodenal stump fistula due to pancreatic fistula after subtotal gastrectomy for advanced gastric cancer
Authors: Moriwake Kazuya , Isozaki Hiroshi , Takama Takehiro , Murakami Shigeki , Matsumoto Sasau 
Published: July 2024

Abstract
Duodenal stump fistula (DSF) is a dangerous complication after gastrectomy. There is no consensus on the management of DSF. Sometimes, emergency surgery may be necessary. We present the case who underwent subtotal gastrectomy with Roux-en-Y reconstruction for advanced gastric cancer. After that surgery, we diagnosed DSF due to pancreatic fistula, and performed reoperation because of hemodynamic instability due to diffuse peritonitis and sepsis. We resected the stump and closed with handsewn suturing and inserted three intra-abdominal drainage tubes, including a dual drainage tube around the duodenal stump. Although there was a recurrence of DSF, because of the continuous and absolute drainage, the patient improved and discharged on postoperative Day 59. From this experience, diligent debridement and a continuous suction dual drainage system, intraluminal drain of the duodenum, and biliary diversion may be an effective surgical management for DFS.
CMB polarization signal demodulation with a rotating half-wave plate
Authors: Rashid Mariam , Brown Michael L , Thomas Daniel B 
Published: July 2024

ABSTRACT
Several forthcoming Cosmic Microwave Background polarization experiments will employ a Continuously Rotating Half-Wave Plate (CRHWP), the primary purpose of which is to mitigate instrumental systematic effects. The use of a CRHWP necessitates demodulating the time-ordered data during the early stages of data processing. The standard approach is to “lock in” on the polarization signal using the known polarization modulation frequency and use Fourier techniques to filter out the remaining unwanted components. However, an alternative, less well-studied option is to incorporate the demodulation directly into the map-making step. Using simulations, we compare the performance of these two approaches to determine which is most effective for B-mode signal recovery. Testing the two techniques in multiple experimental scenarios, we find that the lock-in technique performs best over the full multipole range explored. However, for the recovery of the largest angular scales (multipoles, $\ell \lt 100$) we find essentially no difference in the recovery of the signal between the lock-in and map-making approaches, suggesting that a parallel analysis based on the latter approach could represent a powerful consistency check for primordial B-mode experiments employing a CRHWP. We also investigate the impact of a detector-differencing step, implemented prior to demodulation, finding that, in most scenarios, it makes no difference whether differencing is used or not. However, analysing detectors individually allows the point at which information from multiple detectors is combined to be moved to later stages in the analysis pipeline. This presents alternative options for dealing with additional instrumental systematic effects that are not mitigated by the CRHWP.
Detecting superfluid transition in the pulsar core
Authors: Bagchi Partha , Layek Biswanath , Saini Dheeraj , Sarkar Anjishnu , Srivastava Ajit M , Venkata Deepthi Godaba 
Published: July 2024

ABSTRACT
It is believed that the core of a neutron star can be host to various novel phases of matter, from nucleon superfluid phase to exotic high baryon density quantum chromodynamics (QCD) phases. Different observational signals for such phase transitions have been discussed in the literature. Here, we point out a unique phenomenon associated with phase transition to a superfluid phase, which may be the nucleon superfluid phase or a phase like the colour-flavour locked phase, allowing for superfluid vortices. In any superfluid phase transition, a random network of vortices forms via the so-called Kibble–Zurek mechanism, which eventually mostly decays away, finally leaving primarily vortices arising from the initial angular momentum of the core. This transient, random vortex network can have a non-zero net angular momentum for the superfluid component, which will generally be oriented in an arbitrary direction. This is in contrast to the final vortices, which arise from initial rotation and hence have the initial angular momentum of the neutron star. The angular momentum of the random vortex network is balanced by an equal and opposite angular momentum in the normal fluid due to the conservation of angular momentum, thereby imparting an arbitrarily oriented angular momentum component to the outer shell of the neutron star. This will affect the pulse timing and pulse profile of a pulsar. These changes in the pulses will decay away in a characteristic manner that this as the random vortex network decays, obeying specific scaling laws leading to universal features for the detection of superfluid transitions occurring in a pulsar core.
Final outcome analysis from the phase II TUXEDO-1 trial of trastuzumab-deruxtecan in HER2-positive breast cancer patients with active brain metastases
Authors: Bartsch Rupert , Berghoff Anna Sophie , Furtner Julia , Marhold Maximilian , Bergen Elisabeth Sophie , Roider-Schur Sophie , Mair Maximilian Johannes , Starzer Angelika Martina , Forstner Heidrun , Rottenmanner Beate , Aretin Marie-Bernadette , Dieckmann Karin , Bago-Horvath Zsuzsanna , Haslacher Helmuth , Widhalm Georg , Ilhan-Mutlu Aysegül , Minichsdorfer Christoph , Fuereder Thorsten , Szekeres Thomas , Oehler Leopold , Gruenberger Birgit , Pfeiler Georg , Singer Christian , Weltermann Ansgar , Berchtold Luzia , Preusser Matthias 
Published: July 2024

Abstract

Background
Brain metastases (BM) are a devastating complication of HER2-positive metastatic breast cancer (BC) and treatment strategies providing optimized local and systemic disease control are urgently required. The antibody-drug conjugate trastuzumab deruxtecan (T-DXd) improved progression-free survival (PFS) and overall survival (OS) over trastuzumab emtansine but data regarding intracranial activity is limited. In the primary outcome analysis of TUXEDO-1, a high intracranial response rate (RR) was reported with T-DXd. Here, we report the final PFS and OS results.

Patients and Methods
TUXEDO-1 accrued adult patients with HER2-positive BC and active BM (newly diagnosed or progressing) without indication for immediate local therapy. The primary endpoint was intracranial RR; secondary endpoints included PFS, OS, safety, quality-of-life (QoL), and neurocognitive function. PFS and OS were estimated with the Kaplan-Meier method and analyzed in the per-protocol population.

Results
At 26.5 months median follow-up, median PFS was 21 months (95% CI: 13.3–n.r.) and median OS was not reached (95% CI: 22.2–n.r.). With longer follow-ups, no new safety signals were observed. The most common grade 3 adverse event was fatigue (20%). Grade 2 interstitial lung disease and a grade 3 symptomatic drop of left-ventricular ejection fraction were observed in one patient each. QoL was maintained over the treatment period.

Conclusions
T-DXd yielded prolonged intra- and extracranial disease control in patients with active HER2-positive BC BM in line with results from the pivotal trials. These results support the concept of antibody-drug-conjugates as systemic therapy for active BM.
Rights That
Authors: Eldridge Eleanor 
Published: July 2024

Abstract
Hohfeld was acutely aware of the ‘potent tendency [of words] to control thought’. He was perhaps less aware of the power of syntax to do the same. Hohfeld’s tendency to express the content of duties and liberties in the syntactically restrictive to ϕ form has allowed a corrupted version of his analytical scheme to take root. That version takes as axiomatic that the content of any duty or liberty is the action or inaction of the duty bearer or liberty holder. Yet duties and liberties can (and do) pertain to matters other than the action or inaction of the duty bearer or liberty holder. This insight has a range of doctrinal implications.
The stromal side of the cytochrome b6f complex regulates state transitions
Authors: Riché Alexis , Dumas Louis , Malesinski Soazig , Bossan Guillaume , Madigou Céline , Zito Francesca , Alric Jean 
Published: July 2024

Abstract
In oxygenic photosynthesis, state transitions distribute light energy between PSI and PSII. This regulation involves reduction of the plastoquinone pool, activation of the state transitions 7 (STT7) protein kinase by the cytochrome (cyt) b6f complex, and phosphorylation and migration of light harvesting complexes II (LHCII). In this study, we show that in Chlamydomonas reinhardtii, the C-terminus of the cyt b6 subunit PetB acts on phosphorylation of STT7 and state transitions. We used site-directed mutagenesis of the chloroplast petB gene to truncate (remove L215b6) or elongate (add G216b6) the cyt b6 subunit. Modified complexes are devoid of heme ci and degraded by FTSH protease, revealing that salt bridge formation between cyt b6 (PetB) and Subunit IV (PetD) is essential to the assembly of the complex. In double mutants where FTSH is inactivated, modified cyt b6f accumulated but the phosphorylation cascade was blocked. We also replaced the arginine interacting with heme ci propionate (R207Kb6). In this modified complex, heme ci is present but the kinetics of phosphorylation are slower. We show that highly phosphorylated forms of STT7 accumulated transiently after reduction of the PQ pool and represent the active forms of the protein kinase. The phosphorylation of the LHCII targets is favored at the expense of the protein kinase, and the migration of LHCII toward PSI is the limiting step for state transitions.
RESISTANCE TO PHYTOPHTHORA1 promotes cytochrome b559 formation during early photosystem II biogenesis in Arabidopsis
Authors: Che Li-Ping , Ruan Junxiang , Xin Qiang , Zhang Lin , Gao Fudan , Cai Lujuan , Zhang Jianing , Chen Shiwei , Zhang Hui , Rochaix Jean-David , Peng Lianwei 
Published: July 2024

Abstract
As an essential intrinsic component of photosystem II (PSII) in all oxygenic photosynthetic organisms, heme-bridged heterodimer cytochrome b559 (Cyt b559) plays critical roles in the protection and assembly of PSII. However, the underlying mechanisms of Cyt b559 assembly are largely unclear. Here, we characterized the Arabidopsis (Arabidopsis thaliana) rph1 (resistance to Phytophthora1) mutant, which was previously shown to be susceptible to the oomycete pathogen Phytophthora brassicae. Loss of RPH1 leads to a drastic reduction in PSII accumulation, which can be primarily attributed to the defective formation of Cyt b559. Spectroscopic analyses showed that the heme level in PSII supercomplexes isolated from rph1 is significantly reduced, suggesting that RPH1 facilitates proper heme assembly in Cyt b559. Due to the loss of RPH1-mediated processes, a covalently bound PsbE–PsbF heterodimer is formed during the biogenesis of PSII. In addition, rph1 is highly photosensitive and accumulates elevated levels of reactive oxygen species under photoinhibitory-light conditions. RPH1 is a conserved intrinsic thylakoid protein present in green algae and terrestrial plants, but absent in Synechocystis, and it directly interacts with the subunits of Cyt b559. Thus, our data demonstrate that RPH1 represents a chloroplast acquisition specifically promoting the efficient assembly of Cyt b559, probably by mediating proper heme insertion into the apo-Cyt b559 during the initial phase of PSII biogenesis.
Neuropsychiatric drugs and a neurophysiological marker as predictors of health-related quality of life in patients with phantom limb pain
Authors: Costa Valton , Pacheco-Barrios Kevin , Gianlorenço Anna Carolyna , Fregni Felipe 
Published: July 2024

Abstract

Objective
To explore the relationship between sociodemographic, clinical, and neurophysiological variables and health-related quality of life (HR-QOL) of patients with phantom limb pain (PLP).

Methods
This is a cross-sectional analysis of a previous clinical trial. Univariate and multivariate linear and logistic regression analyses were used to model the predictors of HR-QOL. We utilized a sequential modeling approach with increasing adjustment levels, controlling for age and sex, and other relevant clinical variables (time since amputation, level of amputation, and pain). HR-QOL was assessed by the SF-36 Health Survey and its 8 subdomains.

Results
We analyzed baseline data from 92 patients with lower-limb amputations. They were mostly male (63%), 45.2 ± 15.6 years, with a mean time since amputation of 82.7 ± 122.4 months, and an overall SF-36 score of 55.9 ± 21.5. We found an association between intracortical facilitation (ICF) in the affected hemisphere, gabapentin usage, and HR-QOL. ICF is a predictor of better HRQOL, whereas gabapentin usage was associated with a poorer HR-QOL, with the main model explaining 13.4% of the variance in the outcome. For the SF-36 subdomains, ICF was also a positive predictor for social functioning, bodily pain, and vitality, while medication usage was associated with lower scores in mental health, general health perception, bodily pain, and vitality.

Conclusion
We found firsthand 2 new independent predictors of HR-QOL in individuals with PLP, namely, the neurophysiological metric ICF and gabapentin usage. These results highlight the role of the motor cortex excitability in the HR-QOL and stress the need for treatments that favor the neuroplastic adaptation after amputation, for which ICF may be used as a possible marker.
Safe and effective degradation of aflatoxins by food-grade culture broth of Aspergillus oryzae
Authors: Choi Dasol , Alshannaq Ahmad F , Yu Jae-Hyuk 
Published: July 2024

Abstract
Aflatoxins (AFs) are carcinogenic fungal toxins contaminating up to 25% of the global food supply. Over half of the world's population is exposed to unmonitored levels of AFs, mostly aflatoxin B1 (AFB1). Despite numerous efforts over the past 60 years, there are no solutions to remove AFs safely from food. Here, we present a safe and effective AF-degrading product called “D-Tox”, a filtered culture broth of Aspergillus oryzae grown in a food-grade liquid medium. When 5 ppm of AFB1 is added to D-Tox, ∼90% is degraded at 48 and 24 hr at room temperature and 50°C, respectively. Moreover, when varying amounts (0.1 ppm ∼ 100 ppm) of AFB1 are added to D-Tox at 100°C, over 95% of AFB1 is degraded in 1 hr, suggesting a nonenzymatic process. Examining degradation of 100 ppm AFB1 reveals that aflatoxin D1 (AFD1) is the major transient degradant of AFB1, indicating that degradation occurs irreversibly by lactone ring hydrolysis followed by decarboxylation. D-Tox further degrades AFD1 to unknown fragmented products. Importantly, the practical application of D-Tox is also demonstrated, as more than 70% of AFB1 is degraded when wheat, corn, and peanuts naturally contaminated with high levels of AFB1 (0.3 ∼ 4.5 ppm) are boiled in D-Tox for 1 hr. Additionally, D-Tox can degrade other lactone-ring containing mycotoxins, including patulin and ochratoxin. D-Tox exhibits no cytotoxicity under the conditions tested in MCF-7 breast cancer cell lines. In summary, D-Tox is a safe and effective AF-detoxifying product that can enhance global food safety.
What is to reproduce? On the overlap, development, and persistence account of reproduction
Authors: Palacios-González César 
Published: July 2024

Abstract
Monika Piotrowska has defended a new account of reproduction. Her account seems able to answer the question of whether reproduction takes place, and who reproduces, when we employ biotechnologies that bear little to no resemblance to naturally occurring human sexual reproduction. Piotrowska's account also seems to increase our understanding of biological individuality and seems to be compatible with the theory of evolution via natural selection. In this paper, I do two things. First, I show that Piotrowska's account is found wanting, because it is extensionally inadequate. Second, I show that her criticism of James Grisemer's account of reproduction is mistaken.
A Comparison of the Socioeconomic and Gendered Organization of Social Reproduction in the United States and the United Kingdom, 1973–2013
Authors: Moos Katherine A , Gonalons-Pons Pilar 
Published: July 2024

Abstract
Drawing on both gender regime theory and social reproduction theory, this article compares the socioeconomic and gendered organization of social reproduction in the United States and the United Kingdom from 1973 to 2013. Integrating data from the Luxembourg Income Study, the Multinational Time-Use Study, and additional sources, we examine how men and women of different socioeconomic groups contribute to social reproduction through household production, paid work, and government social benefits. Our results demonstrate that household social reproduction has not been universally refamilialized, marketized, or desocialized in either country. While there is some evidence of degendering, questions remain about its feminist implications.
Weissella paramesenteroidesNRIC1542 inhibits dextran sodium sulfate‐induced colitis in mice through regulating gut microbiota and SIRT1/NF‐κB signaling pathway
Authors: Li Shuang , Chen Junyang , Zheng Yang , Zhang Yun 
Published: July 2024

AbstractInflammatory bowel disease (IBD) is a kind of recurrent inflammatory disorder of the intestinal tract. The purpose of this study was to investigate the effects of Weissella paramesenteroides NRIC1542 on colitis in mice. A colitis model was induced by adding 1.5% DSS to sterile distilled water for seven consecutive days. During this process, mice were administered different concentrations of W. paramesenteroides NRIC1542. Colitis was assessed by DAI, colon length and hematoxylin–eosin staining of colon sections. The expressions of NF‐κB signaling proteins and the tight junction proteins ZO‐1 and occludin were detected by western blotting, and the gut microbiota was analyzed by 16S rDNA. The results showed that W. paramesenteroides NRIC1542 significantly reduced the degree of pathological tissue damage and the levels of TNF‐α and IL‐1β in colonic tissue, inhibiting the NF‐κB signaling pathway and increasing the expression of SIRT1, ZO‐1 and occludin. In addition, W. paramesenteroides NRIC1542 can modulate the structure of the gut microbiota, characterized by increased relative abundance of Muribaculaceae_unclassified, Paraprevotella, Prevotellaceae_UCG_001 and Roseburia, and decrease the relative abundance of Akkermansia and Alloprevotella induced by DSS. The above results suggested that W. paramesenteroides NRIC1542 can protect against DSS‐induced colitis in mice through anti‐inflammatory, intestinal barrier maintenance and flora modulation.
Adverse effects of anti-cancer biologics on the ocular surface
Authors: Shawer Riham , Solomon Abraham 
Published: July 2024

Purpose of review
Cancer immunotherapy is one of the most emerging and rapidly growing fields.
Ocular side effects associated with these therapies are common and can be present in up to 70% of patients.
The cornea may be involved in different pathogenic mechanisms triggered by different immunotherapeutic agents, and corneal disease varies from mild symptoms to severe corneal ulceration and melting with visual loss.
We aimed to review the incidence, mechanism, and management of ocular surface side effects in cancer patients receiving immunotherapy.

Recent findings
With the recent use of immunotherapeutic agents in cancer patients, in particular immune checkpoint inhibitors (ICIs) and epidermal growth factor receptor (EGFR) inhibitors, ocular surface and corneal involvement are common side effects.
These patients can be at risk of sight threatening complications that warrant prompt diagnosis and careful monitoring and management.

Summary
Immunotherapy- related corneal complications in cancer patients are associated with a decreased quality of life. Prompt recognition and an interdisciplinary approach between ophthalmologists and oncologists are crucial to handle immune related ocular adverse events in these patients, in order to maintain ocular surface integrity and avoid a vision threatening complication.