bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective study on the role of Octreotide in management of chyle fistula neck
Authors: Jain Avani , Singh Shashank Nath , Singhal Pawan , Sharma Man Prakash , Grover Mohnish 
Published: January 2015

ObjectiveTo study the effectiveness of octreotide in managing chyle fistula neck and its effect on duration of hospitalization.Study DesignProspective study.MethodsA total of 19 patients with chyle fistula following neck dissection over a period of 10 years were included in the study. All the patients first underwent conservative management of the chyle leak, including suction drainage, pressure dressings, bed rest, and nutritional modifications. In all of the cases, chyle leak persisted despite conservative management. Octreotide was started in a dose of 100 µg subcutaneously every 8 hours for 5 days in cases with low‐output leaks and for 7 days in cases with high‐output leaks. In all of the cases, the duration of chyle leak after starting treatment with octreotide and the duration of hospitalization was recorded.ResultsChyle leak stopped in all the cases using octreotide. The mean duration of hospitalization was 13.8 days.ConclusionChyle leak stopped within 5 days of starting octreotide in the low‐output cases and within 7 days in the high‐output cases. This permitted early resumption of a regular oral diet and reduced morbidity associated with chyle fistula. The rapid response and minimal side effect profile make octreotide a promising addition to the medical management of a chyle fistula.Level of Evidence4.Laryngoscope, 125:1624–1627, 2015
A new method for evaluating lateral semicircular canal cupulopathy
Authors: Kim Chang‐Hee , Shin Jung Eun , Kim Yong Won 
Published: January 2015

Objectives/HypothesisPersistent direction‐changing positional nystagmus (DCPN) during the supine head‐roll test is a typical finding of cupulopathy. The aim of this study was to introduce a simple method of evaluating patients with cupulopathy (light cupula and heavy cupula), which is performed in a seated position, and investigate its diagnostic utility and use for lateralization.Study DesignRetrospective case series.MethodsUsing video‐oculography, nystagmus during head roll in the leaning and bending head positions while seated upright was evaluated in 26 patients with cupulopathy (five light cupula and 21 heavy cupula). The diagnosis of cupulopathy was confirmed with the supine head‐roll test.ResultsSpontaneous nystagmus while seated upright was directed toward the ipsilesional side in heavy cupula and the contralesional side in light cupula. The first null point was identified when the head was slightly bent in the pitch plane in all 26 patients. Head rolling elicited a persistent geotropic DCPN in light cupula patients and persistent apogeotropic DCPN in heavy cupula patients during both leaning and bending head positions. In both light and heavy cupula, nystagmus disappeared when the head was turned slightly toward the affected side in both leaning (second null point) and bending (third null point) head positions.ConclusionsCupulopathy and its affected side can be diagnosed by identifying the three null points while seated upright.Level of Evidence4. Laryngoscope, 125:1921–1925, 2015
Enhanced Performance of Graphene–Epoxy Flexible Capacitors by Means of Ceramic Fillers
Authors: Sangermano Marco , Buzzerio Gianfranco , Rizzoli Rita , Ortolani Luca , Morandi Vittorio , Pirri Fabrizio , Chiolerio Alessandro 
Published: January 2015

Graphene–epoxy flexible capacitors are obtained by graphene–polymer transfer and bonding via UV‐cured epoxy adhesive. Ceramic fillers are dispersed into the epoxy resin with the aim of enhancing the capacitive behavior of the final device. Parallel plate capacitors in which epoxy resin is filled with ceramic nanoparticles demonstrate superior performance, up to two orders of magnitude better than unfilled samples. Zirconia, showing the highest dielectric constant, fails to give a stable output in the whole frequency range, as some competing phenomena occur and reduce the overall polarization of the system. Boehmite appears to be a better choice and gives reasonable performances, better than gibbsite
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Thoracodorsal nerve transfer for triceps reinnervation in partial brachial plexus injuries
Authors: Soldado Francisco , Ghizoni Marcos F. , Bertelli Jayme 
Published: January 2015

PurposeTo report the clinical outcomes of thoracodorsal nerve (TDN) transfers to the triceps motor branches for elbow extension restoration in patients with partial brachial plexus injuries (BPI).MethodsEight male patients of mean age 23 years and suffering from a partial BPI underwent direct coaptation of the TDN to the nerve of the upper medial and long heads of the triceps, an average 6 months after their accident.ResultsSeven patients achieved M4 elbow extension strength and one patient M3, according to the BMRC scale, after a mean follow‐up of 21 months.DiscussionDirect TDN transfer might be a valid surgical procedure for the restoration of elbow extension in patients with partial BPI. © 2015 Wiley Periodicals, Inc. Microsurgery 36:191–197, 2016.
Molecular Determinants for the Binding Mode of Alkylphosphocholines in the C2 Domain of PKCα
Authors: de Sá Matheus M. , Rangel‐Yagui Carlota O. 
Published: January 2015

AbstractAlkylphosphocholines (APCs) and alkyl‐lysophosphocholines (ALPs) are antineoplastic agents that interfere with cellular membranes and signaling proteins. Protein kinase Cα (PKCα) is a signaling protein composed by catalytic (C3, C4) and regulatory domains (C1, C2). The C2 needs calcium (Ca2+) and phosphatidylserine (PS) for activation. Miltefosine inhibits PKCα competitively with regard to PS and non‐competitively with regard to Ca2+, however, the mechanism of action is unknown. We employed molecular docking, molecular dynamics and chemometric methods to verify how 7 APCs and ALPs derivatives and PS interact with the C2 domain. All ligands except PS were grouped in 2 clusters according to their interactions inside the enzyme. The findings showed that PS’s phosphoryl oxygens interact with Ca2+, the serine moiety interacts with Asn189, and the carbonyl oxygen of the alkylic chain interacts with Arg249 and Thr251. On the other hand, ligands’ phosphoryl oxygens interact with Asn189, Arg249, Thr250, and one water molecule instead of Ca2+. Because of the different binding mode, we hypothesize that the ligands cause conformational changes in the calcium binding region. Moreover, the packing mismatch between bilayer‐forming lipids and ALP/APC chain impedes the C2 domain from docking to the internal leaflet of cellular membranes, interrupting PKCα activation.
‘I've Been Walking on Eggshells All My Life’: Fibromyalgia Patients' Narratives About Experienced Violence and Abuse
Authors: Sallinen Merja , Kukkurainen Marja Leena 
Published: January 2015

AbstractAccording to earlier research, the prevalence of violence and abuse in the life history of patients with chronic widespread pain and fibromyalgia seems to be high in comparison with other pain patients and healthy controls. The purpose of the present study was to explore how experiences of violence and abuse are expressed and reflected on and how the causes and consequences of violence are interpreted by female patients with a long history of fibromyalgia. The data were drawn from narrative interviews of 11 women who had earlier participated in a fibromyalgia‐specific rehabilitation course. The findings are presented through three main themes: loss of self‐esteem, physical and mental bruises, and loss of womanhood. The onset of fibromyalgia was perceived as an inevitable result of physical or mental trauma. In conclusion, the narrated life stories indicated that violence is still hidden behind a wall of silence and non‐interference in our society. The devastating mental and physical consequences of violence in different forms may be carried by the individual for years, even decades. Understanding any exposure to violence that a patient has endured may help healthcare professionals to understand the individual's health behaviour and any possible reluctance to undergo treatment and rehabilitation. Copyright © 2015 John Wiley & Sons, Ltd.
Von der DC‐Platte direkt ins Massenspektrometer
Authors: Himmelsbach Markus , Kreisberger Georg , Klampfl Christian W. , Buchberger Wolfgang 
Published: January 2015

AbstractDurch direkte Ionisierung lassen sich Analyten aus der Dünnschichtchromatographie massenspektrometrisch untersuchen. Der Mechanismus der Ionisierung folgt den typischen Elektrospray‐Prinzipien, eine spezielle Ionenquelle ist nicht erforderlich.
Proportionate flow shop: New complexity results and models with due date assignment
Authors: Panwalkar S.S. , Koulamas Christos 
Published: January 2015

AbstractIt is known that the proportionate flow shop minimum makespan problem is solved optimally by any permutation job sequence. We show that the problem is at least ordinary NP‐hard when missing operations are allowed and present some solvable cases. We then consider the standard proportionate flow shop problem (with no missing operations) and show that the solution algorithms for a class of single‐machine due date assignment problems can be extended/generalized to the corresponding proportionate flow shop problems. © 2015 Wiley Periodicals, Inc. Naval Research Logistics 62: 98–106, 2015
X‐linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron
Authors: Hodgkinson Victoria L , Dale Jeffery M , Garcia Michael L , Weisman Gary A , Lee Jaekwon , Gitlin Jonathan D , Petris Michael J 
Published: January 2015

AbstractATP7A is a copper‐transporting P‐type ATPase that is essential for cellular copper homeostasis. Loss‐of‐function mutations in the ATP7A gene result in Menkes disease, a fatal neurodegenerative disorder resulting in seizures, hypotonia and failure to thrive, due to systemic copper deficiency. Most recently, rare missense mutations in ATP7A that do not impact systemic copper homeostasis have been shown to cause X‐linked spinal muscular atrophy type 3 (SMAX3), a distal hereditary motor neuropathy. An understanding of the mechanistic and pathophysiological basis of SMAX3 is currently lacking, in part because the disease‐causing mutations have been shown to confer both loss‐ and gain‐of‐function properties to ATP7A, and because there is currently no animal model of the disease. In this study, the Atp7a gene was specifically deleted in the motor neurons of mice, resulting in a degenerative phenotype consistent with the clinical features in affected patients with SMAX3, including the progressive deterioration of gait, age‐dependent muscle atrophy, denervation of neuromuscular junctions and a loss of motor neuron cell bodies. Taken together, these data reveal autonomous requirements for ATP7A that reveal essential roles for copper in the maintenance and function of the motor neuron, and suggest that SMAX3 is caused by a loss of ATP7A function that specifically impacts the spinal motor neuron. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Programmed cell death 6 interacting protein (PDCD6IP) and Rabenosyn‐5 (ZFYVE20) are potential urinary biomarkers for upper gastrointestinal cancer
Authors: Husi Holger , Skipworth Richard J. E. , Cronshaw Andrew , Stephens Nathan A. , Wackerhage Henning , Greig Carolyn , Fearon Kenneth C. H. , Ross James A. 
Published: January 2015

PurposeCancer of the upper digestive tract (uGI) is a major contributor to cancer‐related death worldwide. Due to a rise in occurrence, together with poor survival rates and a lack of diagnostic or prognostic clinical assays, there is a clear need to establish molecular biomarkers.Experimental designInitial assessment was performed on urine samples from 60 control and 60 uGI cancer patients using MS to establish a peak pattern or fingerprint model, which was validated by a further set of 59 samples.ResultsWe detected 86 cluster peaks by MS above frequency and detection thresholds. Statistical testing and model building resulted in a peak profiling model of five relevant peaks with 88% overall sensitivity and 91% specificity, and overall correctness of 90%. High‐resolution MS of 40 samples in the 2–10 kDa range resulted in 646 identified proteins, and pattern matching identified four of the five model peaks within significant parameters, namely programmed cell death 6 interacting protein (PDCD6IP/Alix/AIP1), Rabenosyn‐5 (ZFYVE20), protein S100A8, and protein S100A9, of which the first two were validated by Western blotting.Conclusions and clinical relevanceWe demonstrate that MS analysis of human urine can identify lead biomarker candidates in uGI cancers, which makes this technique potentially useful in defining and consolidating biomarker patterns for uGI cancer screening.
Continuous output‐feedback finite‐time control for a class of second‐order nonlinear systems with disturbances
Authors: Liu Haitao , Zhang Tie , Tian Xuehong 
Published: January 2015

SummaryIn this paper, a solution to the continuous output‐feedback finite‐time control problem is proposed for a class of second‐order MIMO nonlinear systems with disturbances. First, a continuous finite‐time controller is designed to stabilize system states at equilibrium points in finite time, which is proven correct by a constructive Lyapunov function. Next, because only the measured output is available for feedback, a continuous nonlinear observer is presented to reconstruct the total states in finite time and estimate the unknown disturbances. Then, a continuous output‐feedback finite‐time controller is proposed to track the desired trajectory accurately or alternatively converge to an arbitrarily small region in finite time. Finally, proposed methods are applied to robotic manipulators, and simulations are given to illustrate the applicability of the proposed control approach. Copyright © 2015 John Wiley & Sons, Ltd.
Seeker—Autonomous Long‐range Rover Navigation for Remote Exploration
Authors: Woods Mark , Shaw Andrew , Tidey Estelle , Van Pham Bach , Simon Lacroix , Mukherji Raja , Maddison Brian , Cross Gary , Kisdi Aron , Tubby Wayne , Visentin Gianfranco , Chong Guillermo 
Published: January 2015

Under the umbrella of the European Space Agency (ESA) StarTiger program, a rapid prototyping study called Seeker was initiated. A range of partners from space and nonspace sectors were brought together to develop a prototype Mars rover system capable of autonomously exploring several kilometers of highly representative Mars terrain over a three‐day period. This paper reports on our approach and the final field trials that took place in the Atacama Desert, Chile. Long‐range navigation and the associated remote rover field trials are a new departure for ESA, and this activity therefore represents a novel initiative in this area. The primary focus was to determine if current computer vision and artificial intelligence based software could enable such a capability on Mars, given the current limit of around 200 m per Martian day. The paper does not seek to introduce new theoretical techniques or compare various approaches, but it offers a unique perspective on their behavior in a highly representative environment. The final system autonomously navigated 5.05 km in highly representative terrain during one day. This work is part of a wider effort to achieve a step change in autonomous capability for future Mars/lunar exploration rover platforms.
Coordinate Expansion of Murine Hematopoietic and Mesenchymal Stem Cell Compartments by SHIPi
Authors: Brooks R. , Iyer S. , Akada H. , Neelam S. , Russo C. M. , Chisholm J. D. , Kerr W. G. 
Published: January 2015

Abstract
Promoting the expansion of adult stem cell populations offers the potential to ameliorate radiation or chemotherapy-induced bone marrow failure and allows for expedited recovery for patients undergoing these therapies. Previous genetic studies suggested a pivotal role for SH2 domain-containing inositol-5-phosphatase 1 (SHIP1) in limiting the size of the hematopoietic stem cell (HSC) compartment. The aim of this study was to determine whether our recent development of small molecule SHIP1 inhibitors offers the potential for pharmacological expansion of the HSC compartment in vivo. We show here that treatment of mice with aminosteroid inhibitors of SHIP1 (SHIPi) more than doubles the size of the adult mesenchymal stem cell (MSC) compartment while simultaneously expanding the HSC pool sixfold. Consistent with its ability to target SHIP1 function in vivo, SHIPi also significantly increases plasma granulocyte colony-stimulating factor (G-CSF) levels, a growth factor that supports proliferation of HSC. Here, we show that SHIPi-induced G-CSF production mediates HSC and MSC expansion, as in vivo neutralization of G-CSF abrogates the SHIPi-induced expansion of both the HSC and MSC compartments. Due to its expansionary effect on adult stem cell compartments, SHIPi represents a potential novel strategy to improve declining stem cell function in both therapy induced and genetically derived bone marrow failure syndromes. Stem Cells 2015;33:848–858
Multi‐priority queuing for electric vehicles charging at public supply stations with price variation
Authors: Said Dhaou , Cherkaoui Soumaya , Khoukhi Lyes 
Published: January 2015

AbstractAs electric vehicles (EVs) become more popular, public charging stations for such vehicles will become common. Because the load introduced by such stations on the grid is high, the smart grid will need to balance the load among charging stations in an area while minimizing the charging waiting time. To achieve this goal, we propose two models where vehicles communicate beforehand with the grid to convey information about their charging need and location. In the first model, we develop a mathematical formalism for handling requests for charging vehicles at public charging station based on queuing theory. The second model extends the first one by considering priority queues with two EV classes, high and low, and a cut‐off service discipline. Both models are evaluated while considering mobility of vehicles in an urban scenario and time‐of‐use pricing. Finally, we propose two algorithms for directing vehicles to charging stations in a way to minimize either their waiting time to plug‐in or their waiting time to charge completion. Simulation results show the effectiveness of the proposed approaches when considering both real EV and charging station characteristics and constraints. Copyright © 2014 John Wiley & Sons, Ltd.
Quality of service analysis and improvement with cross layer power allocation in multirelay networks
Authors: Efazati Sara , Azmi Paeiz 
Published: January 2015

AbstractQuality of service (QoS) guarantee is the main performance metric for designing future wireless networks. For real time applications over wireless links, statistical delay QoS guarantee is the most important QoS metrics. The main goal of this paper is studying the effects of multi‐decode‐and‐forward‐relaying transmission on delay QoS guarantee and user satisfaction. For this end, we first propose an approach to simplify the analysis of statistical delay QoS guarantee by the use of a curve named QoS analysis curve. The QoS analysis curve of any system is based on its effective capacity (EC) function. So, we derive a closed‐form expression for the EC function of a multi‐decode‐and‐forward‐relay network to reduce the computational complexity of finding this quantity. After that, for improving the QoS guarantee performance of a multi‐decode‐and‐forward‐relaying system, the EC of the system is maximized by the use of power allocation (PA) technique. At first, an adaptive PA (APA) algorithm is proposed in which the source and relays PA policies are derived analytically. Although, the overhead of this algorithm is large, it significantly improves the statistical delay QoS guarantee performance. Then, for the systems that cannot tolerate the required large overhead of APA, a fixed PA scheme is presented, which is based on particle swarm optimization algorithm. There is a tradeoff between providing the delay QoS guarantee and the required overhead, in selecting APA or fixed PA schemes. The numerical results validate our analytical outcomes and evaluate our proposed algorithms.
Improving drug biological effects by encapsulation into polymeric nanocapsules
Authors: Frank Luiza A. , Contri Renata V. , Beck Ruy C. R. , Pohlmann Adriana R. , Guterres Silvia S. 
Published: January 2015

This review is based on selected reports from 2004 to 2014 and provides a comprehensive and updated overview of the state of the art related to the drug delivery advantages of polymeric nanocapsules, which are a specific type of polymeric nanoparticles used for improvement of biological effects. Special attention is given to the application of nanocapsules to increase the chemical and photostability of drugs, to modulate the interaction with cells and tissues, to reduce adverse effects of drugs, and to increase the drug efficiency and/or bioavailability. Moreover, this review covers in vitro and in vivo studies, highlighting interesting examples of drugs from several therapeutic classes for which efficacy is improved by encapsulation in different types of nanocapsules, especially in lipid‐core nanocapsules. We also briefly present the first results obtained so far attesting to the safety of using polymeric nanocapsules for drug delivery. WIREs Nanomed Nanobiotechnol 2015, 7:623–639. doi: 10.1002/wnan.1334This article is categorized under:

Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
Heterotetranuclear Complexes of Reduced and Non‐reduced Bridging 1,2,4,5‐Tetrazine Ligands with 1,1′‐Bis(diphenylphosphanyl)‐ferrocene‐copper(I)
Authors: Bach Monika , Roy Sayak , Sarkar Biprajit , Bubrin Martina , Niemeyer Mark , Fiedler Jan , Duboc Carole , Kaim Wolfgang 
Published: January 2015

AbstractThe complexes {(μ‐bptz)[Cu(dppf)]2}(BF4)2 [(1)(BF4)2] [bptz = 3,6‐bis(2‐pyridyl)‐1,2,4,5‐tetrazine, dppf = 1,1′‐bis(diphenylphosphanyl)ferrocene] and {(μ‐bpztz)[Cu(dppf)]2}(PF6)2 [(2)(PF6)2] [bpztz = 3,6‐bis(2‐pyrazinyl)‐1,2,4,5‐tetrazine] contain two redox‐active heterodinuclear FeIICuI moieties, bridged by a redox‐active ligand. A crystal structure determination of (1)(BF4)2·2CH2Cl2 confirms the non‐reduced aromatic nature of the bridge, in contrast to previous results on dicopper(I) complexes of bptz. Facile one‐electron reduction produces the radical complexes {(μ‐bptz)[Cu(dppf)]2}+ (1+) and {(μ‐bpztz)[Cu(dppf)]2}+ (2+), which could be isolated [as (1)(BF4)] and studied by variable frequency EPR to provide hyperfine (9.5 GHz) and g anisotropy information (285 GHz). Cyclic voltammetry and UV/Vis/NIR spectroelectrochemistry indicate a reversible two‐electron oxidation of the well separated (ca. 13.4 Å) ferrocene termini.
Cardiac Risk Assessment: Decreasing Postoperative Complications
Authors: Thanavaro Joanne L. 
Published: January 2015

AbstractPreoperative cardiac assessment helps identify patients undergoing noncardiac surgery who are at risk for significant postoperative cardiac complications and those who may benefit from additional preoperative evaluation and perioperative care. Advanced practice nurses can identify surgery‐ and patient‐related risks by conducting a thorough health history and physical examination. Multiple risk indices and evidence‐based guidelines are available to inform health care providers regarding patient evaluation and strategies to reduce postoperative cardiac risk. In general, preoperative tests are recommended only if the findings will influence medical therapy or perioperative monitoring or will require postponement of surgery until a cardiac condition can be corrected or stabilized. Medication management is a crucial component of the preoperative assessment; providers may need to initiate the use of beta‐blockers and make decisions regarding continuing or withholding antiplatelet and anticoagulant therapy. Preoperative cardiac risk stratification, medication reconciliation, and device management are essential for providing safe care for patients.