bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Asymmetric Transfer Hydrogenation of Imines in Water/Methanol Co‐Solvent System and Mechanistic Investigation by DFT Study.
Authors: Shende Vaishali S. , Shingote Savita K. , Deshpande Sudhindra H. , Kuriakose Nishamol , Vanka Kumar , Kelkar Ashutosh A. 
Published: March 2015

Abstract1‐Substituted 6,7‐dimethoxy‐3,4‐dihydroisoquinolines (I) and (III) are used as substrates in the title reaction.
ChemInform Abstract: Chemical and Electrocatalytic Cascade Cyclization of Salicylaldehyde with Three Molecules of Malononitrile: ′One‐Pot′ Simple and Efficient Way to the Chromeno[2,3‐b]pyridine Scaffold.
Authors: Elinson Michail N. , Gorbunov Sergey V. , Vereshchagin Anatoly N. , Nasybullin Ruslan F. , Goloveshkin Alexander S. , Bushmarinov Ivan S. , Egorov Mikhail P. 
Published: March 2015

AbstractAll products are purified by washing with ice‐cold EtOH/Water (9:1).
ChemInform Abstract: Pd‐Catalyzed Intramolecular Aerobic Oxidative C—H Amination of 2‐Aryl‐3‐(arylamino)quinazolinones: Synthesis of Fluorescent Indazolo[3,2‐b]quinazolinones.
Authors: Yang Weiguang , Chen Jiuxi , Huang Xiaobo , Ding Jinchang , Liu Miaochang , Wu Huayue 
Published: March 2015

AbstractThis catalytic reaction with oxygen as the terminal oxidant generates water as the only by‐product and provides a facile approach to indazoloquinazolines.
ChemInform Abstract: Synthesis of 8‐Bromo‐7‐chloro[1,2,4]triazolo[4,3‐c]pyrimidines, Their Ring Rearrangement to [1,5‐c] Analogues, and Further Diversification.
Authors: Tang Caifei , Wang Chao , Li Zhiming , Wang Quanrui 
Published: March 2015

AbstractWhile 2‐unsubstituted pyrimidyl‐hydrazones (I) give directly the [1,5‐c] title compounds (II), 2‐methyl‐ or 2‐phenyl‐substituted substrates (III) or (VI) give the [4,3‐c] title compounds (IV) and (VII), which can be transformed into the [1,5‐c] analogues via Dimroth rearrangement.
ChemInform Abstract: Divergent Reaction: Metal & Oxidant Free Direct C—H Aryloxylation and Hydride Free Formal Reductive N‐Benzylation of N‐Heterocycles.
Authors: Mahato Sujit , Haque Md Ashraful , Dwari Soumita , Jana Chandan K. 
Published: March 2015

AbstractThe reaction of hydroxy‐aryl aldehydes and ketones with cyclic amines yields either fused oxazines via C—H aryloxylation or arylmethylamines via formal reductive amination depending on stoichiometry and reaction conditions.
ChemInform Abstract: Cu(I)—NHC‐Catalyzed Silylation of Allenes: Diastereoselective Three‐Component Coupling with Aldehydes.
Authors: Rae James , Hu Ya Chu , Procter David J. 
Published: March 2015

AbstractThe highly regioselective copper‐catalyzed reaction of aryl allenes with silylborane (II) affords vinyl silane building blocks.
ChemInform Abstract: Synthesis of 2‐Substituted 1,3‐Benzoselenazoles from Carboxylic Acids Promoted by Tributylphosphine.
Authors: Schwartz Radatz Catia , Rampon Daniel S. , Balaguez Renata A. , Alves Diego , Schneider Paulo Henrique 
Published: March 2015

AbstractThe practical and simple method delivers not only 2‐aryl‐1,3‐benzoselenazoles (III), but for the first time also 2‐alkyl‐1,3‐benzoselenazoles (V).
ChemInform Abstract: Immunosuppressive Diterpenes from Phomopsis sp. S12.
Authors: Wei Wei , Gao Jian , Shen Yan , Chu Yan L. , Xu Qiang , Tan Ren X. 
Published: March 2015

AbstractAlong with four known compounds three new diterpenes, myrocin E (I), libertellenone J (II), and libertellenone K (III), are isolated from the culture of phomopsis sp.
ChemInform Abstract: Sterhirsutins A and B, Two New Heterodimeric Sesquiterpenes with a New Skeleton from the Culture of Stereum hirsutum Collected in Tibet Plateau.
Authors: Qi Qiu‐Yue , Bao Li , Ren Jin‐Wei , Han Jun‐Jie , Zhang Zong‐Yao , Li Yi , Yao Yi‐Jian , Cao Rui , Liu Hong‐Wei 
Published: March 2015

AbstractThe two new sterhirsutins A (I) and B (II), as well as the new hirsutic acids D (III) and E (IV) are isolated from Stereum hirsutum.
ChemInform Abstract: Synthesis and Structural Revision of a Brominated Sesquiterpenoid, Aldingenin C.
Authors: Takahashi Shunya , Yasuda Masayuki , Nakamura Takemichi , Hatano Ken , Matsuoka Koji , Koshino Hiroyuki 
Published: March 2015

AbstractCompound (I) is prepared based on the proposed structure of aldingenin C however, the spectral data are different to the reported NMR data of the natural product.
ChemInform Abstract: Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer.
Authors: Yang Ning‐Ning , Ma Qing‐Yun , Huang Sheng‐Zhuo , Dai Hao‐Fu , Guo Zhi‐Kai , Yu Zhi‐Fang , Zhao You‐Xing 
Published: March 2015

Abstractisolation of a new androstane derivative (I) showing significant AChE inhibitory activity along with a known androstane derivative
ChemInform Abstract: Total Synthesis of a Pyrrole Lactone Alkaloid, Longanlactone.
Authors: Reddy Chada Raji , Reddy Motatipally Damoder , Dilipkumar Uredi 
Published: March 2015

AbstractKey reactions in the first asymmetric total assembly of the natural pyrrole lactone longanlactone (I) are a Barbier propargylation and a Paal—Knorr pyrrole synthesis.
ChemInform Abstract: Asymmetric Total Synthesis of Novel Pentacyclic Indole Alkaloid, Kopsiyunnanine E, Isolated from Kopsia Arborea.
Authors: Kitajima Mariko , Murakami Yosuke , Takahashi Nobuaki , Wu Yuqiu , Kogure Noriyuki , Zhang Rong‐Ping , Takayama Hiromitsu 
Published: March 2015

AbstractThe first asymmetric total synthesis of kopsiyunnanine E is described.
ChemInform Abstract: Aspergillines A—E, Highly Oxygenated Hexacyclic Indole—Tetrahydrofuran—Tetramic Acid Derivatives from Aspergillus Versicolor.
Authors: Hu Qiu‐Fen , et al. et al. 
Published: March 2015

AbstractAspergillines A—E are isolated from the endophytic fungus Aspergillus versicolor and their structures are determined spectroscopically.
ChemInform Abstract: A Concise Atroposelective Formal Synthesis of (‐)‐Steganone.
Authors: Yalcouye Boubacar , Choppin Sabine , Panossian Armen , Leroux Frederic R. , Colobert Francoise 
Published: March 2015

AbstractThe formal synthesis of title compound (I) is accomplished by a completely atropodiastereoselective construction of the biaryl unit using a Suzuki—Miyaura cross‐coupling reaction with an enantiopure β‐hydroxy sulfoxide derivative as chiral auxiliary.
ChemInform Abstract: Isocoumarins from the Bark of Lindera caudata.
Authors: Hu Qiu‐Fen , Ye Yan‐qing , Xia Cong‐Fang , Yang Juan‐Xia , Yang Yu‐Chun , Gao Xue‐Mei , Du Gang , Yang Hai‐Ying , Li Yin‐Ke 
Published: March 2015

AbstractThree new isocoumarins, caudacoumarins A‐C (I), are isolated along with two known ones from the bark of Lindera caudata.
ChemInform Abstract: Cytotoxicity Flavones from Desmodium oxyphyllum
Authors: Hu Qiu‐Fen , Gao Xue‐Mei , Wang Huang , Li Yin‐Ke , Ji Bing‐Kun , Xia Cong‐Fang , Yang Juan‐Xia , Zhou Ming , Ye Yan‐Qing 
Published: March 2015

Abstractisolation, structure and cytotoxicity of oxyphyllumflavone A and B, the first naturally occurring flavones possessing a six‐membered 6‐methyl‐α‐pyrone ring
ChemInform Abstract: Color‐Tunable Photoluminescence Phosphors of Ce3+ and Tb3+ Co‐Doped Sr2La8(SiO4)6O2 for UV w‐LEDs.
Authors: Guo Qingfeng , Liao Libing , Mei Lefu , Liu Haikun , Hai Yun 
Published: March 2015

AbstractThe title phosphors are prepared by solid state reactions of SrCO3, SiO2, CeO2, La2O3, and Tb4O7 (alumina crucible, flowing 5%H2/95%N2, 1350 °C, 5 h).
Reaktive Trennung von Essigsäure/Ameisensäure/Wasser‐Gemischen aus der Bioraffinerie
Authors: Painer Daniela , Lux Susanne , Siebenhofer Matthäus 
Published: March 2015

AbstractDie Verarbeitung von Biomasse als Rohstoff in industriellen Prozessen kann zur Bildung von Multikomponentengemischen führen, die bei der destillativen Trennung zur Azeotropbildung neigen. Das ternäre Gemisch Essigsäure/Ameisensäure/Wasser ist dafür ein repräsentatives Beispiel. Eine vielversprechende Lösungsstrategie für die Auftrennung azeotroper Gemische bieten reaktive Trennverfahren, wie beispielsweise die Reaktivdestillation. Durch die Veresterung beider Fettsäuren und die gleichzeitige Abtrennung der leichter siedenden Ester mittels Destillation können die Azeotrope umgangen und eine Isolierung der Reinstoffe ermöglicht werden.
Disentangling CEO compensation: A simultaneous examination of time, industry, and firm‐level effects
Authors: Sur Sujit , Magnan Michel , Cordeiro James 
Published: March 2015

AbstractDespite decades of research, how CEO compensation is determined remains an enigma. Drawing on agency, managerial hegemony, and institutional theoretical perspectives, we use hierarchical linear modelling—a multilevel analytic technique—to examine how firm‐, industry‐, and time‐level effects drive CEO compensation in US corporations. Results show that while cash salary is mostly driven by firm‐specific factors, equity‐based compensation responds to time‐level effects with firm‐ and industry‐level effects playing a marginal role. We argue that such evidence is consistent with the institutionalization of the CEO compensation determination process through the widespread adoption of benchmark peer‐group comparisons. Such practices underlie economy‐wide changes in CEO compensation that are increasingly disconnected from other fundamental firm‐ or industry‐specific factors. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.
Conditional conservatism and persistence of accrual components
Authors: Li Yutao , Zhang Wenjun 
Published: March 2015

AbstractWe examine whether conditional conservatism affects the persistence of accrual components associated with varying degrees of reliability. Using a sample of 102,416 firm‐year observations from 1968 to 2006, we found that conservatism reduces the persistence of more reliable accruals, but not less reliable accruals. Our evidence suggests managers' discretion in practicing conservatism convention may have caused the low persistence of less reliable accruals. Our results inform capital market participants, such as financial analysts, that managers may incorporate more bad news into more reliable accruals than in less reliable accruals, leading to lower persistence of more reliable accruals than less reliable accruals. We expect that analysts can improve forecasting efficiency by understanding the differential implications of accounting conservatism on different accrual components. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.
Evolution of mating behavior between two populations adapting to common environmental conditions
Authors: Bárbaro Margarida , Mira Mário S. , Fragata Inês , Simões Pedro , Lima Margarida , Lopes‐Cunha Miguel , Kellen Bárbara , Santos Josiane , Varela Susana A. M. , Matos Margarida , Magalhães Sara 
Published: March 2015

AbstractPopulations from the same species may be differentiated across contrasting environments, potentially affecting reproductive isolation among them. When such populations meet in a novel common environment, this isolation may be modified by biotic or abiotic factors. Curiously, the latter have been overlooked. We filled this gap by performing experimental evolution of three replicates of two populations of Drosophila subobscura adapting to a common laboratorial environment, and simulated encounters at three time points during this process. Previous studies showed that these populations were highly differentiated for several life‐history traits and chromosomal inversions. First, we show initial differentiation for some mating traits, such as assortative mating and male mating rate, but not others (e.g., female mating latency). Mating frequency increased during experimental evolution in both sets of populations. The assortative mating found in one population remained constant throughout the adaptation process, while disassortative mating of the other population diminished across generations. Additionally, differences in male mating rate were sustained across generations. This study shows that mating behavior evolves rapidly in response to adaptation to a common abiotic environment, although with a complex pattern that does not correspond to the quick convergence seen for life‐history traits.
Chiral Ruthenium Catalyst Immobilized within Magnetically Retrievable Mesoporous Silica Microcapsules for Aqueous Asymmetric Transfer Hydrogenations
Authors: Zoabi Amani , Omar Suheir , Abu‐Reziq Raed 
Published: March 2015

AbstractThe preparation of magnetically separable silica microcapsules that incorporate in their inner shell a chiral catalyst and their application in asymmetric transfer hydrogenation reactions are described. The preparation method is based on the emulsification of an oil phase containing chloroform, a modified Noyori Ru‐TsDPEN catalyst, tetraethoxysilane (TEOS), and hydrophobic magnetic nanoparticles in water in the presence of an appropriate surfactant, followed by an interfacial polycondensation process under basic conditions to generate a silica shell around the oil droplets. The resulting catalytic microreactors can be considered a “quasi‐homogeneous” system because the immobilized chiral catalyst reacts in a homogeneous zone, the microcapsule core filled with an organic solvent. The catalytic activity was tested in the asymmetric transfer hydrogenation of ketones in an aqueous medium. The catalytic reactions took place only in the presence of surfactants. In addition, the judicious selection of the surfactant plays a crucial role in enhancing the reaction progress through the emulsion‐solid transfer (EST) approach. The catalytic activity of the Ru‐TsDPEN catalyst immobilized within the silica microcapsules was superior to the same catalyst supported on silica microspheres or linked to the backbone of a silica sol–gel matrix, which indicates the importance of the homogeneous zones for the reactions.
Differentiation of rice varieties using small bioactive lipids as markers
Authors: Zhu Dan , Nyström Laura 
Published: March 2015

Steryl ferulates (γ‐oryzanol) are a group of important lipid antioxidants found in rice. This study uses OMIC‐technologies to differentiate between rice varieties based on these minor bioactive lipids. The γ‐oryzanol rich‐lipid fractions were first extracted from six types of common cargo rice and two types of wild rice, which were subsequently analyzed using ultra performance liquid chromatography with high‐resolution quadrupole time‐of‐flight mass spectrometric detection (UPLC‐HR‐Q‐TOF‐MS). Unique spectral profiles were produced for each rice variety, and the MS data was further converted into markers. Multivariate statistical analysis including principal component analysis (PCA) and the observed partial least squares‐discriminant analysis (OPLS‐DA) was utilized to find the characteristic markers, enabling us to differentiate between various rice varieties based on their steryl ferulate profiles and other small lipids.Practical applications: This study provides a targeted method to distinguish between various common rice varieties as well as wild rice from different geographic regions, which could be a new approach for rice authentication. Additionally, this sensitive analytical technique may reveal several new compounds of bioactive lipids in rice. Furthermore, the OMIC approach to rice differentiation also has the potential to lead to the selection of rice varieties with optimal profiles of bioactive lipids for food use.Our study provides a novel and targeted method to distinguish between rice varieties using UPLC‐HR‐Q‐TOF‐MS with the OMIC technique. We were able to find characteristic markers that can classify different rice types based on their steryl ferulate profiles and other potential small lipids.
Refinement of the myocutaneous anterolateral thigh flap for reconstruction of frontonasal fistula defects
Authors: Wu Chih‐Wei , Valerio Ian L. , Huang Jung‐Ju , Chang Kai‐Ping , Cheng Ming‐Huei 
Published: March 2015

AbstractBackgroundFrontonasal fistulas can lead to life‐threatening intracranial infections. Our refinement of the myocutaneous anterolateral thigh (ALT) flap for treating these fistulas is described.MethodsA retrospective review of the microsurgical treatment of frontonasal fistulas is presented. Demographics, etiologies, outcomes, and complications were evaluated.ResultsTen myocutaneous ALT flaps were used to reconstruct frontonasal fistula. The mean follow‐up was 35 ± 2.5 months. Nine fistulas were secondary to oncologic resections, and one was due to a traumatic origin. Complications included a recurrent abscess in 1 case (10%); there were no cases of cerebrospinal fluid (CSF) leak or flap loss. Preoperative intracranial infections were present in 7 cases, with 6 successfully resolving their infection after surgical intervention and flap obliteration of their fistulas.ConclusionRefinements in the myocutaneous ALT flap design have been illustrated to provide robust dead‐space obliteration with vascularized muscle and reliable simultaneous scalp coverage in the treatment of frontonasal fistulas. © 2015 Wiley Periodicals, Inc. Head Neck 38: E552–E558, 2016
Bridging the gap between spatial and mnemonic views of the hippocampal formation
Authors: Buffalo Elizabeth A. 
Published: March 2015

ABSTRACTWhile it has long been recognized that medial temporal lobe structures are important for memory formation, studies in rodents have also identified exquisite spatial representations in these regions in the form of place cells in the hippocampus and grid cells in the entorhinal cortex. Spatial representations entail neural activity that is observed when the rat is in a given physical location, and these representations are thought to form the basis of navigation via path integration. Recent studies in nonhuman primates have suggested that similar kinds of spatial representations can be identified, even in the absence of physical movement through an environment. Here, I will highlight some recent work that addresses similarities and differences between spatial responses as identified in rodents and primates. I will also discuss areas of opportunity for future research to further our understanding of the function of the hippocampal formation. © 2015 Wiley Periodicals, Inc.
Is the place cell a “supple” engram?
Authors: Routtenberg Aryeh 
Published: March 2015

ABSTRACTThis short note, which honors Nobelists O'Keefe and the Mosers, asks how the patterning of inputs to a single place cell regulates its firing. Because the combination of inputs to a single CA1 place cell is very large, the generally accepted view is rejected that inputs to a place cell are relatively restricted, near identical repetition upon re‐presentation of the environment. The alternative proposed here is that when any 100 excitatory inputs are fired activating a subset combination, which is a large number, selected from the 30,000 synapses, this leads to CA1 cell firing. The selection of the combination of inputs is a very large number it nonetheless leads to the conclusion that even though the same cell dutifully fires when the animal is in an identical location, the inputs that fire the place cell are nonetheless obligatorily non‐identical. This CA1 input combinatorial proposal may help us understand the physiological underpinnings of the memory mechanism arising from supple synapses (Routtenberg (2013), Hippocampus 23:202–206). © 2015 Wiley Periodicals, Inc.
From the GPS to HM: Place cells, grid cells, and memory
Authors: Knierim James J. 
Published: March 2015

ABSTRACTA longstanding debate in hippocampus research has revolved around how to reconcile spatial mapping functions of the hippocampus with the global amnesia produced by hippocampal damage in humans. Is the hippocampus primarily a cognitive map used to support spatial learning, or does it support more general types of learning necessary for declarative memory? In recent years, a general consensus has emerged that the hippocampus receives both spatial and nonspatial inputs from the entorhinal cortex. The hippocampus creates representations of experience in a particular spatial and temporal context. This process allows the individual components of experience to be stored in such a way that they can be retrieved together as a conscious recollection. © 2015 Wiley Periodicals, Inc.
Current questions on space and time encoding
Authors: Hasselmo Michael E. , Stern Chantal E. 
Published: March 2015

ABSTRACTThe Nobel Prize in Physiology or Medicine 2014 celebrated the groundbreaking findings on place cells and grid cells by John O'Keefe and May‐Britt Moser and Edvard Moser. These findings provided an essential foothold for understanding the cognitive encoding of space and time in episodic memory function. This foothold provides a closer view of a broad new world of important research questions raised by the phenomena of place cells and grid cells. These questions concern the mechanisms of generation of place and grid cell firing, including sensory influences, circuit dynamics and intrinsic properties. Similar questions concern the generation of time cells. In addition, questions concern the functional role of place cells, grid cells and time cells in mediating goal‐directed behavior and episodic memory function. © 2015 Wiley Periodicals, Inc.
CA1‐specific deletion of NMDA receptors induces abnormal renewal of a learned fear response
Authors: Hirsch Silke J. , Regmi Nanda L. , Birnbaum Shari G. , Greene Robert W. 
Published: March 2015

ABSTRACTCA1 hippocampal N‐methyl‐d‐aspartate‐receptors (NMDARs) are necessary for contextually related learning and memory processes. Extinction, a form of learning, has been shown to require intact hippocampal NMDAR signalling. Renewal of fear expression can occur after fear extinction training, when the extinguished fear stimulus is presented in an environmental context different from the training context and thus, renewal is dependent on contextual memory. In this study, we show that a Grin1 knock‐out (loss of the essential NR1 subunit for the NMDAR) restricted to the bilateral CA1 subfield of the dorsal hippocampus does not affect acquisition of learned fear, but does attenuate extinction of a cued fear response even when presented in the extinction‐training context. We propose that failure to remember the (safe) extinction context is responsible for the abnormal fear response and suggest it is a dysfunctional renewal. The results highlight the difference in outcome of extinguished fear memory resulting from a partial rather than complete loss of function of the hippocampus and suggest a potential mechanism for abnormally increased fear expression in PTSD. © 2015 Wiley Periodicals, Inc.
Poly‐3‐hydroxybutyrate production by Azotobacter vinelandii strains in batch cultures at different oxygen transfer rates
Authors: Díaz‐Barrera Alvaro , Andler Rodrigo , Martínez Irene , Peña Carlos 
Published: March 2015

AbstractBACKGROUNDPoly‐3‐hydroxybutyrate (PHB) is a polyester that can be accumulated by Azotobacter vinelandii. This polymer is a biodegradable thermoplastic material used for producing plastics for packaging, biobased films, and biocompatible implants.RESULTSPHB produced by wild‐type A. vinelandii and a mutant OP strain were evaluated at different agitation rates. The oxygen transfer rate (OTR) evolution was characterized in cultures grown at 300, 400, 500 and 600 rpm, showing for the first time the OTR evolution in cultures of mutant OP. Under the conditions evaluated, the cultures were limited by oxygen. In the cultures grown with the OP strain, lower OTR and specific oxygen uptake rate were obtained, indicating a lower necessity for oxygen for growth in this mutant. A higher amount of PHB can be produced by decreasing the OTR. A maximum PHB of 79% on dry weight was observed in the cultures with the wild‐type strain, whereas the highest PHB productivity (0.18 g L−1 h−1) was obtained in cultures of A. vinelandii OP conducted at 600 rpm.CONCLUSIONThe amount of PHB produced during the period of oxygen limitation can be controlled by the OTR, opening the possibility to evaluate this parameter as a criterion for scaling‐up PHB production by A. vinelandii. © 2015 Society of Chemical Industry