bluuebunny/crossref_metadata_2025_split huggingface dataset:
RABL6A Promotes G1–S Phase Progression and Pancreatic Neuroendocrine Tumor Cell Proliferation in an Rb1-Dependent Manner
Authors: Hagen Jussara , Muniz Viviane P. , Falls Kelly C. , Reed Sara M. , Taghiyev Agshin F. , Quelle Frederick W. , Gourronc Francoise A. , Klingelhutz Aloysius J. , Major Heather J. , Askeland Ryan W. , Sherman Scott K. , O'Dorisio Thomas M. , Bellizzi Andrew M. , Howe James R. , Darbro Benjamin W. , Quelle Dawn E. 
Published: October 2014

Abstract
Mechanisms of neuroendocrine tumor (NET) proliferation are poorly understood, and therapies that effectively control NET progression and metastatic disease are limited. We found amplification of a putative oncogene, RABL6A, in primary human pancreatic NETs (PNET) that correlated with high-level RABL6A protein expression. Consistent with those results, stable silencing of RABL6A in cultured BON-1 PNET cells revealed that it is essential for their proliferation and survival. Cells lacking RABL6A predominantly arrested in G1 phase with a moderate mitotic block. Pathway analysis of microarray data suggested activation of the p53 and retinoblastoma (Rb1) tumor-suppressor pathways in the arrested cells. Loss of p53 had no effect on the RABL6A knockdown phenotype, indicating that RABL6A functions independent of p53 in this setting. By comparison, Rb1 inactivation partially restored G1 to S phase progression in RABL6A-knockdown cells, although it was insufficient to override the mitotic arrest and cell death caused by RABL6A loss. Thus, RABL6A promotes G1 progression in PNET cells by inactivating Rb1, an established suppressor of PNET proliferation and development. This work identifies RABL6A as a novel negative regulator of Rb1 that is essential for PNET proliferation and survival. We suggest RABL6A is a new potential biomarker and target for anticancer therapy in PNET patients. Cancer Res; 74(22); 6661–70. ©2014 AACR.
Transcriptome-wide Landscape of Pre-mRNA Alternative Splicing Associated with Metastatic Colonization
Authors: Lu Zhi-xiang , Huang Qin , Park Juw Won , Shen Shihao , Lin Lan , Tokheim Collin J. , Henry Michael D. , Xing Yi 
Published: October 2014

AbstractMetastatic colonization is an ominous feature of cancer progression. Recent studies have established the importance of pre-mRNA alternative splicing (AS) in cancer biology. However, little is known about the transcriptome-wide landscape of AS associated with metastatic colonization. Both in vitro and in vivo models of metastatic colonization were utilized to study AS regulation associated with cancer metastasis. Transcriptome profiling of prostate cancer cells and derivatives crossing in vitro or in vivo barriers of metastasis revealed splicing factors with significant gene expression changes associated with metastatic colonization. These include splicing factors known to be differentially regulated in epithelial–mesenchymal transition (ESRP1, ESRP2, and RBFOX2), a cellular process critical for cancer metastasis, as well as novel findings (NOVA1 and MBNL3). Finally, RNA-seq indicated a large network of AS events regulated by multiple splicing factors with altered gene expression or protein activity. These AS events are enriched for pathways important for cell motility and signaling, and affect key regulators of the invasive phenotype such as CD44 and GRHL1.Implications: Transcriptome-wide remodeling of AS is an integral regulatory process underlying metastatic colonization, and AS events affect the metastatic behavior of cancer cells. Mol Cancer Res; 13(2); 305–18. ©2014 AACR.
Perioperative management of oral antiplatelet therapy and clinical outcomes in coronary stent patients undergoing surgery
Authors: Musumeci Giuseppe , Capodanno Davide , Lettieri Corrado , Limbruno Ugo , Tarantini Giuseppe , Russo Nicolina , Calabria Paolo , Romano Michele , Inashvili Ana , Sirbu Vasile , Guagliumi Giulio , Valsecchi Orazio , Senni Michele , Gavazzi Antonello , Angiolillo Dominick J. , Rossini Roberta 
Published: October 2014

SummaryThe aim was to investigate the perioperative risk of ischaemic and bleeding events in patients with coronary stents undergoing cardiac and non-cardiac surgery and how these outcomes are affected by the perioperative use of oral antiplatelet therapy. This was a multicentre, retrospective, observational study conducted in patients with coronary stent(s) undergoing cardiac or non-cardiac surgery. The primary efficacy endpoint was the 30-day incidence of major adverse cardiac events (MACE), defined as the composite of cardiac death, myocardial infarction (MI) or stroke. The primary safety endpoint was the 30-day incidence of Bleeding Academic Research Consortium (BARC) bleeding ≥ 2. A total of 666 patients were included. Of these, 371 (55.7 %) discontinued their antiplatelet medication(s) (all or partly) before undergoing surgery. At 30 days, patients with perioperative discontinuation of antiplatelet therapy experienced a significantly higher incidence of MACE (7.5 % vs 0.3 %, p < 0.001), cardiac death (2.7 % vs 0.3 %, p=0.027), and MI (4.0 % vs 0 %, p < 0.001). After adjustment, peri-operative antiplatelet discontinuation was the strongest independent predictor of 30-day MACE (odds ratio [OR]=25.8, confidence interval [CI]=3.37–198, p=0.002). Perioperative aspirin (adjusted OR 0.27, 95 % CI 0.11–0.71, p=0.008) was significantly associated with a lower risk of MACE. The overall incidence of BARC ≥ 2 bleeding events at 30-days was significantly higher in patients who discontinued oral antiplatelet therapy (25.6 % vs 13.9 %, p < 0.001). However, after adjustment, antiplatelet discontinuation was not independently associated with BARC ≥ 2 bleeding. In conclusion antiplatelet discontinuation increases the 30-day risk of MACE, in patients with coronary stents undergoing cardiac and non-cardiac surgery, while not offering significant protection from BARC≥ 2 bleeding.
Role of protein S deficiency in children with venous thromboembolism
Authors: Kenet Gili , Kurnik Karin , Gelas Martine Alhenc , Finckh Ulrich , Junker Ralf , Heller Christine , Zieger Barbara , Knöfler Ralf , Holzhauer Susanne , Mesters Rolf , Krümpel Anne , Klostermeier Ulrich C. , Limperger Verena , Nowak-Göttl Ulrike 
Published: October 2014

SummaryVenous thromboembolism [TE] is a multifactorial disease, and protein S deficiency [PSD] constitutes a major risk factor. In the present study the prevalence of PSD and the clinical presentation at TE onset in a cohort of children is reported. In 367 unselected paediatric patients with TE (age 0.1–18 years) recruited between July 1996 and December 2013, a comprehensive thrombophilia screening was performed along with recording of anamnestic data. Thirty of 367 paediatric patients (8.2 %) derived from 27 families had PSD. Mean age at first TE onset was 14.5 years (range 0.1 to 18). Thrombotic locations were cerebral veins (n=8), calf vein TE (n=3) deep veins (DVT) of the leg (n=12), DVT & pulmonary embolism (n=5) and intra-cardiac veins (n=1) or purpura fulminans (n=1). PSD co-occurred with the factor 5 mutation at rs6025 or the homozygous factor 2 susceptibility variant at rs1799963 in one case each. The Heerlen polymorphism detected in five children presented with milder PSD. In 18 patients (60 %) a concomitant risk factor for TE was identified. A second TE event within primarily healthy siblings occurred in three of 27 PSD families (11.0 %). In this cohort of children with symptomatic TE, the prevalence of PSD adjusted for family status was 7.4 %. Given its clinical implication for patients and family members, thrombophilia testing should be performed and the benefit of medical or educational interventions should be evaluated in this high-risk population.
Modality Dependent Cross-Modal Functional Reorganization Following Congenital Visual Deprivation within Occipital Areas: A Meta-Analysis of Tactile and Auditory Studies
Authors: Ricciardi Emiliano , Tozzi Leonardo , Leo Andrea , Pietrini Pietro 
Published: October 2014

Cross-modal responses in occipital areas appear to be essential for sensory processing in visually deprived subjects. However, it is yet unclear whether this functional recruitment might be dependent on the sensory channel conveying the information. In order to characterize brain areas showing task-independent, but sensory specific, cross-modal responses in blind individuals, we pooled together distinct brain functional studies in a single based meta-analysis according only to the modality conveying experimental stimuli (auditory or tactile).
Our approach revealed a specific functional cortical segregation according to the sensory modality conveying the non-visual information, irrespectively from the cognitive features of the tasks. In particular, dorsal and posterior subregions of occipital and superior parietal cortex showed a higher cross-modal recruitment across tactile tasks in blind as compared to sighted individuals. On the other hand, auditory stimuli activated more medial and ventral clusters within early visual areas, the lingual and inferior temporal cortex. These findings suggest a modality-specific functional modification of cross-modal responses within different portions of the occipital cortex of blind individuals. Cross-modal recruitment can thus be specifically influenced by the intrinsic features of sensory information.
The Effectiveness of a Rearview Camera and Parking Sensor System Alone and Combined for Preventing a Collision With an Unexpected Stationary or Moving Object
Authors: Kidd David G. , Hagoski Bradly K. , Tucker Tia G. , Chiang Dean P. 
Published: October 2014

Objective: This study measured the effectiveness of a parking sensor system, a rearview camera, and a sensor system combined with a camera for preventing a collision with a stationary or moving child-size object in the path of a backing vehicle. Background: An estimated 15,000 people are injured and 210 are killed every year in backover crashes involving light vehicles. Cameras and sensor systems may help prevent these crashes. Method: The sample included 111 drivers (55 men, 56 women), including 16 in the no-technology condition, 32 in the sensor condition, 32 in the camera condition, and 31 in the camera-plus-sensor condition. A stationary or moving child-size object was surreptitiously deployed in the path of participants backing out of a parking stall. Results: A significantly smaller proportion of participants in the camera condition hit the stationary object compared with participants in the no-technology condition; however, this benefit was greatly reduced when the stationary object was partially or completely in the shade. Significantly fewer participants hit the moving object than the stationary object. The percentage of participants in the sensor, camera, and camera-plus-sensor conditions who hit the moving object was not different from the no-technology condition. Conclusion: The camera was the only technology that was effective for preventing collisions with the stationary object. The variation in collision outcomes between the stationary- and moving-object conditions illustrates how the effectiveness of these technologies is dependent on the backing situation. Application: This research can help the selection and development of countermeasures to prevent backovers.
The Double Confrontation of Grassroots Unionism in Argentina
Authors: Arias Cora Cecilia , Menéndez Nicolás Diana , Salgado Paula Dinorah 
Published: October 2014

Social conflicts in Argentina over the past decade have retrieved the essence of the capitalist dispute: the struggle between capital and labor as situated in the workplace and no longer across urban space as it was in the 1990s. In this context, both institutionalized and alternative union expressions regained their centrality for analyzing social reality. The revitalization of collective bargaining and the consequent repositioning of unions on the labor and political scene activated grassroots dynamics that sometimes challenged existing union structures. Few experiences of resistance were able to alter the balance of power as much as the workers’ organization of the Buenos Aires subway. This organization was able to achieve such gains because of a combination of the strategic importance of the subway to the city’s production and reproduction, the fact that the privatization of the firm was a time-limited concession rather than a direct sale, the union tradition and workers’ awareness of lost rights, and the incorporation of new workers with a history of political militancy. Los conflictos sociales en Argentina durante la última década han recuperado la esencia de la disputa capitalista: la lucha entre el capital y los trabajadores como situado en el lugar de trabajo y ya no a través del espacio urbano, como lo fue en la década de 1990. En este contexto, las dos expresiones sindicales institucionalizadas y alternativas recuperaron su centralidad para el análisis de la realidad social. La revitalización de la negociación colectiva y la consecuente reposición de los sindicatos sobre el escenario laboral y político activan dinámicas de base que a veces desafiaban las estructuras sindicales existentes. Pocas experiencias de resistencia fueron capaces de cambiar al equilibrio de poder tanto como la organización de trabajadores del metro de Buenos Aires. Esta organización fue capaz de lograr tales ganancias debido a una combinación de la importancia estratégica del metro para la producción y reproducción de la ciudad, el hecho de que la privatización de la empresa fue una concesión de tiempo limitado más bien que una venta directa, la tradición sindical y la conciencia de los trabajadores de los derechos perdidos, y la incorporación de nuevos trabajadores con antecedentes de militancia política.
Nonanatomic Anterior Cruciate Ligament Reconstruction With Double-Stranded Semitendinosus Grafts in Children With Open Physes
Authors: Demange Marco Kawamura , Camanho Gilberto Luis 
Published: October 2014

Background: Nonanatomic anterior cruciate ligament (ACL) reconstruction (ACLR) with double-stranded semitendinosus grafts in children with open physes has been described as a successful surgical technique in short-term follow-up clinical reports. Purpose: To evaluate the clinical outcomes of nonanatomic ACLR in children with open physes and a minimum of 15 years’ follow-up. Study Design: Case series; Level of evidence, 4. Methods: Twelve patients with an average age of 10.7 years (range, 8.3-12.4 years) underwent ACLR between 1991 and 1998. All patients were classified as Tanner development stage 2 or lower. The surgical technique involved transphyseal tibial tunnel drilling and over-the-top (OTT) femoral fixation using a double-stranded graft for all patients. Clinical outcomes were evaluated in terms of the manual Lachman test, pivot-shift test, return to sports activity, and International Knee Documentation Committee (IKDC) score at the end of growth and at a minimum 15-year follow-up (range, 15-22 years). Results: No clinically significant growth disturbance was observed. Ten patients had a grade A IKDC score, and 2 patients had a grade B IKDC score at the end of growth. There was no progression of laxity or modification of knee stability with growth. Three patients (25%) had ACL reruptures during sports activities after growth plate closure. All patients with reruptured ACLs underwent additional reconstructive surgery. Conclusion: Anterior cruciate ligament reconstruction using the OTT technique in the femur and the transphyseal technique in the tibia produces good results with regard to growth plate closure but a high failure rate in adulthood.
The pathogenesis of Kirner’s deformity: A clinical, radiological and histological study
Authors: Fairbank S. M. , Rozen W. M. , Coombs C. J. 
Published: October 2014

The distal phalanx in Kirner’s disease is abnormal and recognizable both clinically and radiologically. Despite previous investigation, the cause of these abnormalities is not clear. The current study seeks to evaluate the abnormal physis in Kirner’s deformity using radiological investigation, intraoperative observation and histopathological assessment in three clinical cases. Similarities with clinodactyly are described. Three patients with Kirner’s deformity underwent plain-film radiography and magnetic resonance imaging. Intraoperative observations were recorded, and histologic assessment of anatomically abnormal tissue was performed in all three cases. All three modalities of investigation (plain-film X-rays, magnetic resonance imaging and histological findings) were consistent and supported the intraoperative observation of cartilage abnormally situated anterior to the diaphysis and deep to the flexor tendon. There is thus evidence for the presence of an incomplete volar bracket or L-shaped physis in Kirner’s deformity, analogous with the C-shaped bracket found in clinodactyly. Level of Evidence: Aetiological Study; Level 4
Cognitive processing of cluster headache patients: evidence from event-related potentials
Authors: Wang Rongfei , Dong Zhao , Chen Xiaoyan , Liu Ruozhuo , Zhang Mingjie , Wu Jinglong , Yu Shengyuan 
Published: October 2014

Abstract

Background
The peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in fact central regions might be more important. Event-related potentials confer advantages in the functional evaluation of the cortex, but few studies thus far have employed this method in cluster headache.

Methods
Seventeen cluster patients (15 males; mean age = 35.4 years) and 15 age-matched healthy participants (13 males; mean age = 34.6 years) were recruited. A visual oddball paradigm was employed to analyze target processing using event-related potentials. We investigated the P3/P3d components in the experiment.

Results
P3/P3d amplitudes were decreased in CH patients (P3, 3.82 μV; P3d, 5.8 μV) compared with controls (P3, 7.28 μV; P3d, 8.95 μV), F(1,30) = 4.919, p < 0.05, η2 = 0.141 for P3 and F(1,30) = 8.514, p < 0.05, η2 = 0.221 for P3d, respectively). Moreover, the amplitudes of P3/P3d were no significantl difference in the side of pain as compared to contralateral one (p > 0.05).

Conclusions
These results provide evidence of dysfunction in the cognitive processing of CH patients, which may also contribute to the pathophysiology of CH.
Dose-intense capecitabine, oxaliplatin and bevacizumab as first line treatment for metastatic, unresectable colorectal cancer: a multi-centre phase II study
Authors: Jackson Christopher GCA , Sharples Katrina , Thompson Paul I , O’Donnell Anne , Robinson Bridget Anne , Perez David J , Adams Jacqui , Isaacs Richard , Deva Sanjeev , Hinder Victoria A , Findlay Michael P 
Published: October 2014

Abstract

Background
Dose intense chemotherapy may improve efficacy with acceptable toxicity. A phase II study was conducted to determine the feasibility of a dose-intense two weekly schedule of capecitabine, oxaliplatin, and bevacizumab in metastatic colorectal cancer (mCRC).

Methods
49 patients with previously untreated mCRC were recruited. Nineteen received capecitabine (1750 mg/m2 oral BD days 1–7)oxaliplatin (85 mg/m2i.v. day 1) and bevacizumab (5 mg/kg i.v. day 1) using a 14-day cycle (C1750). Following toxicity concerns capecitabine was reduced to 1500 mg/m2oral BD (C1500) and 30 further patients recruited.

Results
Over 80% of patients received at least 75% of planned chemotherapy doses over the first two cycles. At C1750 Grade 3 or higher toxicity occurred in 74% (95% CI 49% to 91%) and on C1500 in 70% (95% CI 51% to 85%). The median progression-free survival was 6.9 months (95% CI 4.7 to 8.7) for C1750 dose and 8.9 months (95% CI 4.1 to 12.4) for C1500. 3 treatment-related deaths occurred.

Conclusions
Dose intense capecitabine and oxaliplatin with bevacizumab does not show additional efficacy and has potentially significant toxicity. Its use outside of clinical trials is not recommended.

Trial registration

ISRCTN41540878
Unique and facile solvothermal synthesis of mesoporous WO3 using a solid precursor and a surfactant template as a photoanode for visible-light-driven water oxidation
Authors: Li Dong , Chandra Debraj , Saito Kenji , Yui Tatsuto , Yagi Masayuki 
Published: October 2014

Abstract
Mesoporous tungsten trioxide (WO3) was prepared from tungstic acid (H2WO4) as a tungsten precursor with dodecylamine (DDA) as a template to guide porosity of the nanostructure by a solvothermal technique. The WO3 sample (denoted as WO3-DDA) prepared with DDA was moulded on an electrode to yield efficient performance for visible-light-driven photoelectrochemical (PEC) water oxidation. Powder X-ray diffraction (XRD) data of the WO3-DDA sample calcined at 400°C indicate a crystalline framework of the mesoporous structure with disordered arrangement of pores. N2 physisorption studies show a Brunauer-Emmett-Teller (BET) surface area up to 57 m2 g-1 together with type IV isotherms and uniform distribution of a nanoscale pore size in the mesopore region. Scanning electron microscopy (SEM) images exhibit well-connected tiny spherical WO3 particles with a diameter of ca. 5 to 20 nm composing the mesoporous network. The WO3-DDA electrode generated photoanodic current density of 1.1 mA cm-2 at 1.0 V versus Ag/AgCl under visible light irradiation, which is about three times higher than that of the untemplated WO3. O2 (1.49 μmol; Faraday efficiency, 65.2%) was evolved during the 1-h photoelectrolysis for the WO3-DDA electrode under the conditions employed. The mesoporous electrode turned out to work more efficiently for visible-light-driven water oxidation relative to the untemplated WO3 electrode.
The effects of surface spin on magnetic properties of weak magnetic ZnLa0.02Fe1.98O4 nanoparticles
Authors: Xu Shitao , Ma Yongqing , Xu Yuanfeng , Sun Xiao , Geng Bingqian , Zheng Ganhong , Dai Zhenxiang 
Published: October 2014

Abstract
In order to prominently investigate the effects of the surface spin on the magnetic properties, the weak magnetic ZnLa0.02Fe1.98O4 nanoparticles were chosen as studying objects which benefit to reduce as possibly the effects of interparticle dipolar interaction and crystalline anisotropy energies. By annealing the undiluted and diluted ZnLa0.02Fe1.98O4 nanoparticles at different temperatures, we observed the rich variations of magnetic ordering states (superparamagnetism, weak ferromagnetism, and paramagnetism). The magnetic properties can be well understood by considering the effects of the surface spin of the magnetic nanoparticles. Our results indicate that in the nano-sized magnets with weak magnetism, the surface spin plays a crucial rule in the magnetic properties.
Phase-pure iron pyrite nanocrystals for low-cost photodetectors
Authors: Liu Shenting , Wu Jiang , Yu Peng , Ding Qinghua , Zhou Zhihua , Li Handong , Lai Chih-chung , Chueh Yu-Lun , Wang Zhiming M 
Published: October 2014

Abstract
Earth-abundant iron pyrite (FeS2) shows great potential as a light absorber for solar cells and photodetectors due to their high absorption coefficient (>105 cm-1). In this paper, high-quality phase-pure and single crystalline pyrite nanocrystals were synthesized via facile, low-cost, and environment friendly hydrothermal method. The molar ratio of sulphur to iron and the reaction time play a crucial role in determining the quality and morphology of FeS2 nanocrystals. X-ray diffraction and high-resolution transmission electron microscopy confirm that phase-pure and single crystalline pyrite nanocrystals can be synthesized with high sulphur to iron molar ratio and sufficient reaction time. For the first time, a crystalline nanogap pyrite photodetector with promising photocurrent and UV-visible photoresponse has been fabricated. This work further demonstrates a facile route to synthesize high-quality FeS2 nanomaterials and their potential in optoelectronic applications.