bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longer healthy life, but for how many? A stochastic analysis of healthy lifespan inequality
Authors: Zarulli Virginia , Caswell Hal 
Published: August 2024

AbstractOver the past 150 years, life expectancy doubled and healthy life expectancy increased. Expectations reveal nothing about variability, so we present a stochastic analysis to investigate changes over time, age and gender of variation, among individuals, in healthy lifespan, for different levels of country income. To complement health-adjusted life expectancy (HALE) data from the Global Burden of Disease Study, we use a stochastic model to compute the standard deviation of healthy life (SDHL). The model is a finite-state absorbing Markov chain with rewards. It includes stochastic survival, mortality, and loss of good health status. An individual surviving from one age to the next gains, as a "reward," a year of good health. This method provides all the moments of healthy longevity. The mean healthy longevity is exactly the HALE. As a measure of variation, here we focus on the standard deviation of healthy longevity. From 1990 to 2019, HALE increased, with greater increases at younger ages. At the same time, SDHL at younger ages decreased and at older ages increased. The most significant changes at birth occurred in low- and lower-middle-income countries. High- and upper-middle-income countries saw notable increases at old ages. Women generally have longer HALE and higher SDHL, but the overall HALE increase was greater for men. The reduction in SDHL over time suggests that more individuals benefit from increased longevity, particularly in low-income countries closing the gap with high-income countries. However, improvements in healthy survival at older ages appear unevenly distributed among individuals in high-income countries.
Bridging K-12 Student Mental Health Policy to Practice Gaps with a Multi-Component Framework
Authors: Brindley Lindsay , Bauer Paul , Card Alan J. , Crocker John , Ialongo Nick , Tien Allen 
Published: August 2024

AbstractK-12 schools are a major sector for efforts to prevent and treat student mental health problems. In the United States, these efforts have led to the emergence of the MultiTiered System of Supports (MTSS) universal prevention, early intervention, and treatment policy framework. With a major focus on behavioral and mental health, MTSS has been adopted by all fifty state education departments. However, multi-level complexities of addressing student mental health within and across organizational structures complicate MTSS and broader policy development, implementation, and evaluation; disconnects between policy writers and practitioners obstruct progress, limiting positive outcomes. To bridge these policy-to-practice gaps, a multi-component solution is needed. The authors propose integrating the following elements: the Massachusetts School Mental Health Consortium’s Five Guiding Principles for Building a Coordinated School Mental Health System, the comprehensive school improvement methodology Evolutionary Systems Improvement (ESI); and the ontological framework of BioPsychoSocioTechnical Systems Theory (BPST). Individual application of these components has already yielded systems-level improvements outperforming compliance-driven procedures. Used together, these components offer a multi-level solution for establishing conceptually-guided, measurement-based loops that transcend the restrictions of uninformed policy, supporting stakeholders as they work to systematically eliminate barriers and improve student mental health.
Should we change the term we use for “climate change”? Evidence from a national U.S. terminology experiment
Authors: Bruine de Bruin Wändi , Kruke Laurel , Sinatra Gale M. , Schwarz Norbert 
Published: August 2024

AbstractThe terms “global warming,” “climate crisis,” “climate emergency,” and “climate justice” each draw attention to different aspects of climate change. Psychological theories of attitude formation suggest that people’s attitudes can be influenced by such variations in terminology. In a national experiment, we randomly assigned a national sample of 5,137 U.S. residents to “climate change,” “global warming,” “climate crisis,” “climate emergency,” or “climate justice” and examined their responses. Overall, “climate change” and “global warming” were rated as most familiar and most concerning, and “climate justice” the least, with ratings for “climate crisis” and “climate emergency” falling in between. Moreover, we find no evidence for “climate crisis” or “climate emergency” eliciting more perceived urgency than “climate change” or “global warming.” Rated willingness to support climate-friendly policies and eat less red meat were less affected by presented terms, but they were lowest for “climate justice.” Although effects of terms on rated familiarity, concern, and perceived urgency varied by political leaning, “climate justice” generally received the lowest ratings on these variables among Democrats, Republicans, and Independent/others. Auxiliary analyses found that when terms were unfamiliar, participants were generally less likely to express concern, urgency, policy support, or willingness to eat less red meat. We therefore recommend sticking with familiar terms, conclude that changing terminology is likely not the key solution for promoting climate action, and suggest alternative communication strategies.
Agricultural soils in climate change mitigation: comparing action-based and results-based programmes for carbon sequestration
Authors: Block Julia B. , Hermann Daniel , Mußhoff Oliver 
Published: August 2024

AbstractRemoving greenhouse gases from the atmosphere is a major challenge for today’s society. A great source of potential for greenhouse gas sequestration is beneath our feet: agricultural soil. By accumulating soil organic carbon in soil, farmers can sequester carbon dioxide and simultaneously reach soils more resilient to extreme weather events. To encourage farmers to build up humus and thus sequester carbon, some humus programmes have been developed by non-governmental organisations. In this regard, action-based reward systems are on their way to challenging the established results-based approaches. Against this background, we analyse how action-based and results-based approaches, as well as other crucial features of humus programmes, affect farmers’ willingness to participate in a humus programme. We conducted a Discrete-Choice-Experiment and analysed it using a mixed logit model. The results show that farmers have a statistically significant preference for action-based humus programmes, shorter programme durations, higher incentives, and an annual and government-funded payment. More specifically, farmer participation is twice as likely if humus formation is rewarded for action rather than results. The willingness-to-accept calculation indicates that a results-based humus programme would cost the funding agency about €20 more per ton of carbon dioxide sequestered in the soil. Above all, humus programmes with an action-based approach and annual payments would increase farmers’ willingness to participate. Our results contribute to the development of targeted humus programmes and policies to increase carbon sequestration in agricultural soils.
Community Pharmacists’ Views on Their Roles in Mental Health Screening and Management in Malaysia
Authors: Mok Shien Loong , Chuah Jing Ying , Lee Kun Jin , Lim Yee Dom , Appalasamy Jamuna Rani , Saw Pui San , Selvaraj Amutha 
Published: August 2024

AbstractCommunity pharmacists (CPs) are vital as primary healthcare providers, particularly in the screening and management of mental health issues. This study aimed to explore CPs’ views on mental health support for patients and the potential challenges in delivering mental health services. Malaysian CPs were recruited through purposive and snowballing sampling. Semi-structured interviews were recorded and transcribed verbatim. Data was thematically analyzed using NVivo 12 management software. Twenty CPs from Peninsular Malaysia were interviewed. Participants emphasized the importance of high-quality resources, comprehensive training and standardized tools to effectively provide mental healthcare services. Challenges identified were lack of knowledge and skills, absence of screening tools and social stigma and conservatism, particularly among older individuals. This study underscores the willingness of CPs taking a primary role in mental health services. However, collaboration with relevant stakeholders is crucial, aligning with national strategic plans for the program to be successful.
Performance of tropical and subtropical maize inbred lines under well-watered and drought-stressed environments
Authors: Dube Sweetbird P. , Shayanowako Admire I. T. , Kutu Funso , Sibiya Julia 
Published: August 2024

AbstractDrought is a major constraint for maize production in sub-Saharan Africa. Developing high-yielding drought-tolerant maize germplasm will safeguard maize yields in the ever-increasing fluctuating rainfall conditions. This study aimed to identify high-yielding inbred lines with stable performance for utilization in hybrid production. One hundred eighty-two (182) maize inbred lines were evaluated under well-watered and drought-stressed conditions at Ukulinga, Makhathini, and Cedara research stations in KwaZulu-Natal, South Africa. The experiments were carried out in a 13 × 14 alpha lattice design with two replications. The inbred lines exhibited significant differences (p ≤ 0.001) for grain yield and yield-related traits under well-watered and drought-stressed environments. The GGE biplot identified three mega-environments, clearly separating drought-stressed from well-watered environments. Inbred lines TZISTR1190, TZISTR1231, TZISTR1261 and CML540 were superior under well-watered conditions, while TZISTR1164 and CML390 performed well under drought condition. TZISTR1190 displayed both high average yield and stability across environments. Inbred lines combining stable high yielding performance in optimum and stress conditions such as TZISTR1190 and TZISTR1231, can be incorporated into local maize breeding pipelines to develop stable high yielding resilient hybrids.
The utility of urine sodium–guided diuresis during acute decompensated heart failure
Authors: Siddiqi Hasan K. , Cox Zachary L. , Stevenson Lynne W. , Damman Kevin , ter Maaten Jozine M. , Bales Brian , Han Jin H. , Ivey-Miranda Juan B. , Lindenfeld JoAnn , Miller Karen F. , Ooi Henry , Rao Veena S. , Schlendorf Kelly , Storrow Alan B. , Walsh Ryan , Wrenn Jesse , Testani Jeffrey M. , Collins Sean P. 
Published: August 2024

AbstractDiuresis to achieve decongestion is a central aim of therapy in patients hospitalized for acute decompensated heart failure (ADHF). While multiple approaches have been tried to achieve adequate decongestion rapidly while minimizing adverse effects, no single diuretic strategy has shown superiority, and there is a paucity of data and guidelines to utilize in making these decisions. Observational cohort studies have shown associations between urine sodium excretion and outcomes after hospitalization for ADHF. Urine chemistries (urine sodium ± urine creatinine) may guide diuretic titration during ADHF, and multiple randomized clinical trials have been designed to compare a strategy of urine chemistry–guided diuresis to usual care. This review will summarize current literature for diuretic monitoring and titration strategies, outline evidence gaps, and describe the recently completed and ongoing clinical trials to address these gaps in patients with ADHF with a particular focus on the utility of urine sodium–guided strategies.
Does promotion foster career sustainability? A comparative three-wave study on the role of promotion in work stress, job satisfaction, and career-related performance
Authors: Udayar Shagini , Urbanaviciute Ieva , Maggiori Christian , Rossier Jérôme 
Published: August 2024

AbstractThe present study investigates the role of promotion in employees’ happiness (job satisfaction), health (work stress), and career-related performance (perceived employability and career prospects). Positive and negative changes in the above-mentioned career sustainability indicators were investigated over a 2-year period. The promotion subsample (n = 128) was compared with a matched sample of non-promoted employees (n = 150). We also tested the role of gender in responding to a promotion. The findings suggest that the promotion may have equivocal effects on employees’ happiness, health, and career-related performance over time, and therefore does not foster their career sustainability.
Tocilizumab unfolds colo-protective and immunomodulatory effect in experimentally induced ulcerative colitis via mitigating autophagy and ER stress signaling
Authors: Younes Omnia A. , Elsherbiny Doaa M. , Hanna Diana M. F. , Gad Amany M. , Azab Samar S. 
Published: August 2024

AbstractUlcerative colitis (UC) is an idiopathic, chronic, relapsing inflammatory bowel disease (IBD), characterized by chronic inflammation of the gastrointestinal tract. The pathophysiology of UC is complicated and involves several factors including immune, genetic, and environmental factors. Recently, a huge amount of research has concentrated on the role of interleukins including interleukin-6 (IL-6) in its pathophysiology. Thus, this study aims to examine the colo-protective and immunomodulatory effect of Tocilizumab (TCZ) in an experimental model of dextran sulfate sodium (DSS) induced UC. In the current study, we analyzed the inflammatory, immunomodulatory, apoptotic, autophagy, and endoplasmic reticulum (ER) stress markers and other clinical features including stool consistency, rectal bleeding, and edema markers in rats. Our results showed that induction of colitis caused bloody diarrhea and increased IL-6 levels. Treatment with TCZ significantly ameliorated DSS-induced injury via decreasing inflammatory markers of colon injury (IL-6), signal transducer and activator of transcription-3 (STAT-3), and C-reactive protein (CRP). Furthermore, TCZ attenuated the apoptotic marker (caspase-3), and down-regulated endoplasmic reticulum stress sensor proteins (inositol- requiring transmembrane kinase endonuclease-1 (IRE-1) and activated transcription factor-6 (ATF-6)) and autophagy proteins (autophagy-related 16-like protein 1 (ATG16L1) and nucleotide-binding oligomerization domain-containing protein-2 (NOD2)), as compared to DSS group. Altogether, the current data suggest TCZ to be a promising protective therapy against UC.
Graphical Abstract
Continuous Equality Knapsack with Probit-Style Objectives
Authors: Fravel Jamie , Hildebrand Robert , Travis Laurel 
Published: August 2024

AbstractWe study continuous, equality knapsack problems with uniform separable, non-convex objective functions that are continuous, antisymmetric about a point, and have concave and convex regions. For example, this model captures a simple allocation problem with the goal of optimizing an expected value where the objective is a sum of cumulative distribution functions of identically distributed normal distributions (i.e., a sum of inverse probit functions). We prove structural results of this model under general assumptions and provide two algorithms for efficient optimization: (1) running in linear time and (2) running in a constant number of operations given preprocessing of the objective function.
System identification and force estimation of robotic manipulator using semirecursive multibody formulation
Authors: Pyrhönen Lauri , Mikkola Aki , Naets Frank 
Published: August 2024

AbstractForce estimation in multibody dynamics relies heavily on knowing the system model with a high level of accuracy. However, in complex mechatronic systems, such as robots or mobile machinery, the values of model parameters may be only roughly estimated based on design information, such as CAD data. The errors in model parameters consequently have a direct effect on force estimation accuracy because the estimator compensates the erroneous inertia, friction, and applied forces by changing the value of estimated external force. The objective of this study is to present the workflow of system identification and state/force estimation of an open-loop multibody structure. The system identification utilizes a linear regression identification method used in robotics adapted to the multibody framework. The semirecursive multibody formulation, in particular, is studied as a formulation for both system identification and force estimation. The multibody state/force estimator is constructed using extended Kalman filter. The specific aim of this paper is to demonstrate the utilization of these per se known modeling, identification, and estimation tools to address their current lack of integration as a complete toolchain in virtual sensing of multibody systems. The methodology of the study is tested with both artificial and experimental data of Stäubli TX40 robotic manipulator. In the experimental analysis, an openly available benchmark data set was used. Artificial data were created by running an inverse dynamics analysis with inertia and friction parameters taken from literature. The results show that the multibody inertia and friction parameters can be accurately identified and the identified model can be used to produce decent estimates of external forces. The proposed multibody system identification method itself opens new opportunities in tuning the multibody models used in product development. Moreover, effective use of system identification together with state estimation helps to build more accurate estimators. When the system model is accurately identified, the capability of state estimator to observe unknown inputs, such as external forces, is significantly enhanced.
Public awareness of rip currents among American adults
Authors: O’Halloran Chris , Silver Mary 
Published: August 2024

Abstract
Rip current awareness is essential for safety of the beach-going American public. In this study, we investigated American adults’ awareness of ocean safety via an online survey. A total of 1226 respondents participated in the survey. The results revealed that only 44% of the participants were aware that rip currents are the major cause of drownings in the United States. Most participants (64%) reported that the best way to escape a rip current was by swimming parallel (sideways) to the shore, while 8% reported it to be floating and letting the current carry one; further 3% of the respondents mentioned screaming for help as a rescue measure. Interestingly, while most of the respondents reported they could swim (71%), the number of White participants among swimmers was four times higher than that of their Asian, Black, American Indian, and Latino counterparts. Furthermore, less than half of the respondents (44%) reported reading and following the posted beach signs with safety information, while around one-fourth (23%) reported swimming near lifeguards. We also found a strong association between the respondents’ knowledge about how to escape a rip current and reading beach ocean safety signs. The findings of this study contribute to previous research on rip currents and may assist in developing more effective ocean safety interventions for the diverse American public visiting various marine environments along the vast U.S. coastline.
Logic Families
Authors: Andréka Hajnal , Gyenis Zalán , Németi István , Sain Ildikó 
Published: August 2024

AbstractA logic family is a bunch of logics that belong together in some way. First-order logic is one of the examples. Logics organized into a structure occur in abstract model theory, institution theory and in algebraic logic. Logic families play a role in adopting methods for investigating sentential logics to first-order like logics. We thoroughly discuss the notion of logic families as defined in the recent Universal Algebraic Logic book.
AdaptUI: A Framework for the development of Adaptive User Interfaces in Smart Product-Service Systems
Authors: Carrera-Rivera Angela , Larrinaga Felix , Lasa Ganix , Martinez-Arellano Giovanna , Unamuno Gorka 
Published: August 2024

AbstractSmart Product–Service Systems (S-PSS) represent an innovative business model that integrates intelligent products with advanced digital capabilities and corresponding e-services. The user experience (UX) within an S-PSS is heavily influenced by the customization of services and customer empowerment. However, conventional UX analysis primarily focuses on the design stage and may not adequately respond to the evolving user needs during the usage stage and how to exploit the data surrounding the use of S-PSS. To overcome these limitations, this article introduces a practical framework for developing Adaptive User Interfaces within S-PSS. This framework integrates ontologies and Context-aware recommendation systems, with user interactions serving as the primary data source, facilitating the development of adaptive user interfaces. One of the main contributions of this work lies on the integration of various components to achieve the creation of Adaptive User Interfaces for digital services. A case study of a smart device app is presented, to demonstrate the practical implementation of the framework, with a hands-on development approach, considering technological aspects and utilizing appropriate tools. The results of the evaluation of the recommendation engine show that using a context-aware approach improves the precision of recommendations. Furthermore, pragmatic aspects of UX, such as usefulness and system efficiency, are evaluated with participants with an overall positive impact on the use of the smart device.
Pirfenidone inhibits TGF-β1-induced fibrosis via downregulation of Smad and ERK pathway in MDCK cells
Authors: Im Chae-Yoon , Kim Se-Hoon , Song Ki-Hoon , Ryu Min-Ok , Youn Hwa-Young , Seo Kyoung-Won 
Published: August 2024

AbstractThe prevalence of chronic kidney disease (CKD) in dogs increases with age, and renal fibrosis is an important pathophysiological mechanism in this process. However, only a few drugs that can effectively inhibit fibrosis in the kidneys of dogs are currently available. In this study, we aimed to determine whether pirfenidone, a drug that has shown antifibrotic effects in various clinical studies, also exerts antifibrotic effects on canine renal tubular epithelial cells, Madin-Darby canine kidney cells (MDCK). To this end, we treated MDCK cells with various concentrations of pirfenidone, followed by transforming growth factor-beta1 (TGF-β1) to stimulate fibrotic conditions. A cell viability assay was performed to determine the effect of pirfenidone on cell survival. Fibrosis-related markers and TGF-β1 fibrotic pathway-related markers were assessed using qPCR, Western blot analysis and immunocytochemistry. A one-way analysis of variance (ANOVA) was performed, followed by Tukey’s post-hoc test for multiple comparisons. Pirfenidone treatment significantly reduced the expression of profibrotic markers such as α-smooth muscle actin, fibronectin, and collagen. Additionally, it upregulated the expression of E-cadherin, an epithelial marker. Furthermore, pirfenidone effectively inhibited the phosphorylation of key factors involved in the TGF-β1 signaling pathway, including Smad2/3 and ERK1/2. These results demonstrate that pirfenidone suppresses TGF-β1-induced fibrosis in MDCK cells by attenuating epithelial-mesenchymal transition and the relevant signaling pathways.