bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine‐needle aspiration in desmoplastic small round cell tumor: A report of 10 new tumors in 8 patients with clinicopathological and molecular correlations with review of the literature
Authors: Klijanienko Jerzy , Colin Pierre , Couturier Jérôme , Lagacé Réal , Fréneaux Paul , Pierron Gaëlle , Laé Marick , Klijanienko Alice , Brisse Hervé , Orbach Daniel , Theocharis Stamatios 
Published: March 2014

BACKGROUNDDesmoplastic small round cell tumor (DSRCT) is a rare round cell sarcoma entity characterized by a specific t(11;22)(p13;q12) translocation, usually intra‐abdominal localization and an aggressive clinical outcome. To date, only 35 DSRCT cases diagnosed by fine‐needle aspiration have been described.METHODSThis study reports the cytological diagnosis of DSRCT. Ten tumors from 8 patients were sampled for diagnosis and analyzed to search the characteristic translocation using fluorescence in situ hybridization or reverse transcription polymerase chain reaction methods.RESULTSSmears were always hypercellular and consisted of nonspecific round cell sarcoma. Nuclei were polymorphic round, kidney‐, or heart‐shaped. Nuclear molding was usually present. Paranuclear cytoplasmic densities were obvious and noted in 7 cases. Cytonuclear atypia, mitotic figures, numerous crushed nuclei, and apoptosis were frequently seen. Purple‐stained stroma was present in 8 cases (ranging from few connective tissue fragments to large hyalinized deposits). Molecular studies based on cytological aspirates were performed in 8 patients. The presence of the fusion gene EWSR1‐WT 1 transcript was identified in all, which confirmed the diagnosis of DSRCT.CONCLUSIONSSmears showing poorly differentiated round cells associated with cytoplasmic densities and connective stoma, in a specific clinical context, young adult age, intra‐abdominal localization, suggestive immunocytochemical profile, and a unique cytogenetic abnormality are highly specific and allow an accurate diagnosis of DSRCT. Cancer (Cancer Cytopathol) 2014;122:386–393. © 2014 American Cancer Society.
A Wait‐List Randomized Controlled Trial of Loving‐Kindness Meditation Programme for Self‐Criticism
Authors: Shahar Ben , Szepsenwol Ohad , Zilcha‐Mano Sigal , Haim Netalee , Zamir Orly , Levi‐Yeshuvi Simi , Levit‐Binnun Nava 
Published: March 2014

Self‐criticism is a vulnerability risk factor for a number of psychological disorders, and it predicts poor response to psychological and pharmacological treatments. In the current study, we evaluated the efficacy of a loving‐kindness meditation (LKM) programme designed to increase self‐compassion in a sample of self‐critical individuals. Thirty‐eight individuals with high scores on the self‐critical perfectionism subscale of the Dysfunctional Attitude Scale were randomized to an LKM condition (n = 19) or a wait‐list (WL) condition (n = 19). Measures of self‐criticism, self‐compassion and psychological distress were administered before and immediately following the intervention (LKM or WL). WL participants received the intervention immediately after the waiting period. Both groups were assessed 3 months post‐intervention. Intent‐to‐treat (n = 38) and per‐protocol analyses (n = 32) showed significant reductions in self‐criticism and depressive symptoms as well as significant increases in self‐compassion and positive emotions in the LKM condition compared with the WL condition. A follow‐up per‐protocol analysis in both groups together (n = 20) showed that these gains were maintained 3 months after the intervention. These preliminary results suggest that LKM may be efficacious in alleviating self‐criticism, increasing self‐compassion and improving depressive symptoms among self‐critical individuals. Copyright © 2014 John Wiley & Sons, Ltd.Key Practitioner MessageSelf‐criticism plays a major role in many psychological disorders and predicts poor response to brief psychological and pharmacological treatments for depression.The current study shows that loving‐kindness meditation, designed to foster self‐compassion, is efficacious in helping self‐critical individuals become less self‐critical and more self‐compassionate.The study also suggests that practising loving‐kindness may reduce depressive symptoms and increase positive emotions.
Impedance flow cytometry gauges proliferative capacity by detecting TRPC1 expression
Authors: Crocetti Sara , Beyer Christian , Unternährer Silvio , Benavides Damm Tatiana , Schade‐Kampmann Grit , Hebeisen Monika , Di Berardino Marco , Fröhlich Jürg , Franco‐Obregón Alfredo 
Published: March 2014

AbstractWhen examined, the expansion of many stem cell classes has been shown to be facilitated by mechanically‐regulated calcium entry from the extracellular space that also helps direct their developmental programs towards mechanosensitive tissues such as muscle, bone, and connective tissues. Cation channels of the transient receptor potential C class (TRPC) are the predominant conduit for calcium entry into proliferating myoblasts. Nonetheless, methods to non‐invasively study this calcium‐entry pathway are still in their infancy. Here we show that a microfluidic configuration of impedance‐based flow cytometry (IFC) provides a method to detect TRP channel expression in cells at high throughput. Using this technology we discern changes in the IFC signal that correlates with the functional expression of TRPC1 channels and coincides with cell proliferation. Pharmacological agents, mechanical conditions or malignant states that alter the expression of TRPC1 channels are reflected in the IFC signal accordingly, whereas pharmacological agents that alter cation‐permeation through TRPC1 channels, or ionophores that independently increase calcium entry across the membrane, have little effect. Our results suggest that IFC detects changes in whole‐cell membrane organization associated with TRPC1 activation and surface expression, rather than cation permeation through the channel per se. IFC‐based technologies thus have the potential to identify living stem cells in their earliest stages of expansion without staining or chemical fixation. © 2014 International Society for Advancement of Cytometry
Determinants of direct and indirect costs in anorexia nervosa
Authors: Stuhldreher Nina , Wild Beate , König Hans‐Helmut , Konnopka Alexander , Zipfel Stephan , Herzog Wolfgang 
Published: March 2014

ABSTRACTObjectiveTo estimate direct and indirect costs of anorexia nervosa (AN), and to identify cost determinants.MethodsIn a subsample (n = 225) of the ANTOP trial (Anorexia Nervosa Treatment of OutPatients) health care utilization and productivity losses were assessed at baseline for the previous 3 months and monetarily valued. Included were females aged 18 years and older diagnosed with AN or subsyndromal AN, and a body mass index (BMI) between 15 and 18.5 kg/m2. To account for missing data multiple imputation was employed. Cost determinants were derived from generalized linear models with gamma distribution and log link function.ResultsMean 3‐months costs per patient amounted to €5,866 (SE = €576). The largest share of costs (€3,374) resulted from hospitalizations. Determinants of direct costs were analyzed separately for those with hospitalizations for AN, and those without. In the group only treated as outpatients, participants with binge/purge subtype, and those diseased for more than 6 years had higher costs. Moreover, costs were increased in patients with a comorbid mental disorder. In the group with hospitalizations, direct costs increased with BMI. BMI was measured at the end of the observation period, indicating that longer duration of treatment yielded higher weight gain. Indirect costs were not significantly associated with any disease‐related characteristic.DiscussionCosts resulting from health care utilization and productivity loss are substantial, although the sample studied had not received sufficient treatment. Future research should analyze the development of costs over time. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:139–146)
Which host‐dependent insects are most prone to coextinction under changed climates?
Authors: Moir Melinda L. , Hughes Lesley , Vesk Peter A. , Leng Mei Chen 
Published: March 2014

AbstractCoextinction (loss of dependent species with their host or partner species) presents a threat to untold numbers of organisms. Climate change may act synergistically to accelerate rates of coextinction. In this review, we present the first synthesis of the available literature and propose a novel schematic diagram that can be used when assessing the potential risk climate change represents for dependent species. We highlight traits that may increase the susceptibility of insect species to coextinction induced by climate change, suggest the most influential host characteristics, and identify regions where climate change may have the greatest impact on dependent species. The aim of this review was to provide a platform for future research, directing efforts toward taxa and habitats at greatest risk of species loss through coextinction accelerated by climate change.
Selective Synthesis of Stannoles by 1,1‐Carboboration of Bis(trimethylsilylethynyl)tin Compounds Using Weakly and Strongly Electrophilic Triorganoboranes: Characterization of a Zwitterionic Intermediate
Authors: Wrackmeyer Bernd , Thoma Peter , Marx Simone , Bauer Tobias , Kempe Rhett 
Published: March 2014

AbstractThe triorganoboranes BEt3, BPh3, and B(C6F5)3 were allowed to react with bis(trimethylsilylethynyl)diorganotin compounds [R12Sn(C≡C–SiMe3)2; R12 = –(CH2)5– (a), R1 = nBu (b), nOct (c), Ph (d)] to give selectively and quantitatively stannoles. The reactions proceeded by 1,1‐carboboration in two consecutive steps (inter‐ and intramolecular) and intermediates were detected by NMR spectroscopy. In one case, using the strongly electrophilic B(C6F5)3, a zwitterionic intermediate was isolated and structurally characterized by X‐ray diffraction analysis. The question of reversibility of the 1,1‐carboboration is addressed. Multinuclear magnetic resonance spectroscopy (1H, 11B, 13C, 19F, 29Si, 119Sn NMR) was used to characterize the intermediates and the stannoles as the final products. Some of the NMR parameters (11B, 13C, 29Si) of the intermediates were calculated by DFT methods using the optimized gas‐phase geometries.
Total Synthesis of Quebrachamine through Macrolactamization
Authors: Hsu Shih‐Wen , Cheng Hsiu‐Yi , Huang An‐Chi , Ho Tse‐Lok , Hou Duen‐Ren 
Published: March 2014

AbstractThe total synthesis of quebrachamine was achieved through the macrolactamization of cis‐2‐alkenylated indole 17, which was prepared by a Sonogashira reaction between indole 5b and piperidine 11 followed by cis‐hydrogenation. We found that stoichiometric copper(I) iodide limited the undesired Glaser‐type homocoupling of alkyne 11 that would otherwise take place during the Sonogashira coupling. This direct approach allowed the total synthesis in ten linear steps starting from commercially available chemicals. Conditions for the reduction of lactam 19 by lithium aluminiumhydride were adjustable, so that either (±)‐quebrachamine or the analogue (±)‐kopsiyunnanine D was prepared.
Flash Vacuum Thermolysis of N‐(3‐ and 4‐Pyridylmethylidene)‐tert‐butylamines: Mechanisms of Formation of Pyrrolopyridines and Naphthyridines
Authors: Justyna Katarzyna , Leśniak Stanisław , Nazarski Ryszard B. , Rachwalski Michał , Vu Thien Y. , Huynh Thi Kieu Xuan , Khayar Saïd , Dargelos Alain , Chrostowska Anna , Wentrup Curt 
Published: March 2014

AbstractPyrrolopyridines and naphthyridines are formed by flash vacuum thermolysis (FVT) of 3‐ and 4‐pyridylmethylidene‐tert‐butylimines 8 and 15. Elimination of a methyl radical generates resonance stablized 2‐azaallyl radicals a1 and b1. The formation of pyrrolopyridines 9, 16 and 17 is rationalized in terms of cyclization of 1‐aziridinyl radicals a2 and b2. Formation of naphthyridine 10 from imine 8, and of 11 and 18 from imine 15, are in accord with cyclization of 1‐azaallyl radicals a6 and b9. Formation of naphthyridine 11 from 8, and of 10 and 19 from 15, indicate the operation of the spiro‐cyclization pathways forming intermediates a9 and b14. Formation of the 1,8‐naphthyridine 20 (3 %) indicates a rearrangement through aziridine b22 and biradical b23. DFT calculations at the CAM‐B3LYP/6‐311G(d,p) level support the proposed reaction mechanisms.
IBX‐Mediated Dehydrogenation of Substituted β‐Oxonitriles
Authors: Klahn Philipp , Kirsch Stefan F. 
Published: March 2014

AbstractA convenient method for the mild dehydrogenation of β‐oxonitriles is presented. When treated with o‐iodoxybenzoic acid (IBX), a range of these compounds were transformed into their unsaturated counterparts. Furthermore, we show that the products of the dehydrogenation can react in situ, undergoing rapid hetero‐Diels–Alder reactions with enol ethers to give multiply substituted dihydropyrans. We also describe the dehydrogenation of cyclic β‐oxonitriles, which leads to the formation of substituted phenols.
Late Abrahamic reunion? Religious fundamentalism negatively predicts dual Abrahamic group categorization among Muslims and Christians
Authors: Kunst Jonas R. , Thomsen Lotte , Sam David L. 
Published: March 2014

AbstractAlthough extensive research has documented the effectiveness of common or dual in‐groups on improving intergroup relations, little is known about how individual‐difference variables affect people's willingness to make such re‐categorizations in the first place. Here, we demonstrate that individual differences in religious fundamentalism predict willingness to categorize in terms of the common Abrahamic religious origins of Christianity and Islam among Christians and Muslims. Study 1 (n = 243 Christians, 291 Muslims) uses multigroup structural equation modeling and Study 2 (n = 80 Christians) an experimental manipulation to show that religious fundamentalism causes lower dual Abrahamic categorization, which, in turn, predicts more positive attitudes toward the respective out‐group, mediating the negative effects of religious fundamentalism on religious intergroup bias. While making the general case that individual differences may play important roles for dual categorizations, these results also highlight the specific positive potential of dual ecumenical categorizations for improving interreligious relations. Research and societal implications are discussed. Copyright © 2014 John Wiley & Sons, Ltd.
Esterification of hydrolyzed sea mango (Cerbera odollam) oil using various cationic ion exchange resins
Authors: Kansedo Jibrail , Lee Keat Teong 
Published: March 2014

AbstractThis study investigates the esterification of hydrolyzed sea mango (Cerbera odollam) oil using several cationic ion exchange resins. The best resins were selected based on their performance in a preliminary esterification process. The best resins were then subsequently used in the optimization of the process parameters. The esterification parameters studied were reaction temperature (40–160°C), reaction time (0–5 h), molar ratio of oil to methanol (0.5:1 to 1:14), and catalyst loading (1–14 wt%). Among the resins studied, Amberlyst 15 was found to be the most promising catalyst in the esterification of the hydrolyzed sea mango oil. Moderate reaction temperatures, 60–100°C, were found to be adequate in converting the hydrolyzed sea mango oil into esters. Further investigation revealed that the esterification reaction using the cationic ion exchange resins proceeds at a fast rate, whereby fatty acid methyl esters (FAME) yield of over 80% at moderate reaction temperature was achievable in less than 1 h of reaction time. Small amount of catalyst, which is less than 5 wt%, was also found to be sufficient in catalyzing the esterification process to an acceptable yield.
Performance analysis of TCP over visible light communication networks with ARQ‐SR protocol
Authors: Mai Vuong V. , Tran Ngoc‐Anh , Thang Truong C. , Pham Anh T. 
Published: March 2014

ABSTRACTThis paper theoretically studies the performance of transmission control protocol (TCP) over visible light communications (VLC) networks when the automatic‐repeat request, selective repeat (ARQ‐SR) protocol is employed in the link layer. We analytically derive TCP throughput considering the impact of ARQ‐SR parameters and different VLC physical factors, including inter‐symbol interference (ISI), signal reflection and light power distribution. Numerical results show that TCP throughput is strongly dependent on the location of VLC user due to impacts of ISI and signal reflection. It is also seen that the use of ARQ‐SR could significantly improve both the maximum value and the distribution of TCP throughput in the VLC network. Especially, with a proper selection of the number of re‐transmissions by the ARQ‐SR protocol, the dependence of TCP throughput on user location caused by ISI, light signal reflection and distribution could be effectively remedied. Copyright © 2014 John Wiley & Sons, Ltd.
Fabrication of Function‐Graded Proton Exchange Membranes for Direct Methanol Fuel Cells Using Electron Beam‐Grafting
Authors: Tsuchida R. , Hiraiwa S. , Tsukamoto A. , Washio M. , Oshima A. 
Published: March 2014

AbstractFunction‐graded proton exchange membranes (G‐PEMs) based on poly(tetrafluoroethylene‐co‐hexafluoropropylene) were fabricated for direct methanol fuel cells (DMFCs) via electron beam‐grafting using the heterogeneous energy deposition technique. The G‐PEMs had a water uptake gradient in the proton transfer direction, originating from the sulfonic acid group gradient. The distribution of sulfonic acid groups in the various G‐PEMs was evaluated using X‐ray photoelectron spectroscopy. Four types of PEMs (flat‐type, strong‐gradient, meso‐gradient, and weak‐gradient types) were fabricated. By varying the direction of the G‐PEMs, the methanol permeation test and DMFC operation were performed with two orientations of the sulfonic acid group gradient, decreasing from the methanol injection (anode) side (decrease‐type) or the other (cathode) side (increase‐type). The methanol permeability of the strong‐gradient, meso‐gradient, and weak‐gradient G‐PEMs was lower than that of Nafion®117 and the flat‐type PEM. The “increase‐type” orientation of the strong‐gradient G‐PEM resulted in the lowest methanol permeability. The DMFC performance of the G‐PEMs was influenced by the thickness direction, such as “decrease‐type” and “increase‐type.” The performance of the “decrease‐type” assembly was higher than that of the “increase‐type.” The “decrease‐type” assembly with P‐200 k (weak‐gradient G‐PEM) exhibited the highest performance of the fabricated PEMs, comparable to that of Nafion®117.
Coral Microstructure of Graded CGO/LSCF Oxygen Electrode by Electrostatic Spray Deposition for Energy (IT‐SOFC, SOEC)
Authors: Sar J. , Charlot F. , Almeida A. , Dessemond L. , Djurado E. 
Published: March 2014

AbstractThe goal of this work was to fabricate a composite based on Ce0.9Gd0.1O1.95 (CGO) and La0.6Sr0.4Co0.2Fe0.8O3–δ (LSCF) as a porous and thin oxygen electrode film adherent to (ZrO2)0.92(Y2O3)0.08 (YSZ) substrate by electrostatic spray deposition in order to improve durability in solid oxide fuel cells operating at intermediate temperature (IT‐SOFC) and solid oxide electrolyzer cells. A simultaneous gradient in composition and in porosity of CGO/LSCF coatings has been successfully obtained by choosing proper deposition parameters and physicochemical properties of the precursor solution. Detailed microstructural characterization was made by SEM and completed with 3D focused ion beam‐scanning electron microscope (FIB‐SEM) tomography. The graded composition rich in CGO close to YSZ and rich in LSCF at the electrode surface has been investigated by energy dispersive X‐ray spectroscopy through line profile of coral microstructure. Only cubic CGO and cubic LSCF perovskite were detected by XRD in deposited coatings after heat treatment at 900 °C for 2 h.
Efficacy and safety of Ginkgo biloba extract EGb 761® in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo‐controlled, double‐blind, multi‐center trial
Authors: Gavrilova S. I. , Preuss U. W. , Wong J. W. M. , Hoerr R. , Kaschel R. , Bachinskaya N. ,   the GIMCIPlus Study Group
Published: March 2014

ObjectiveThe study was conducted to explore the effects of EGb 761® (Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany) on neuropsychiatric symptoms (NPS) and cognition in patients with mild cognitive impairment (MCI).MethodsOne hundred and sixty patients with MCI who scored at least 6 on the 12‐item Neuropsychiatric Inventory (NPI) were enrolled in this double‐blind, multi‐center trial and randomized to receive 240 mg EGb 761 daily or placebo for a period of 24 weeks. Effects on NPS were assessed using the NPI, the state sub‐score of the State‐Trait Anxiety Inventory and the Geriatric Depression Scale. Further outcome measures were the Trail‐Making Test (A/B) for cognition and global ratings of change. Statistical analyses followed the intention‐to‐treat principle.ResultsThe NPI composite score decreased by 7.0 ± 4.5 (mean, standard deviation) points in the EGb 761‐treated group and by 5.5 ± 5.2 in the placebo group (p = 0.001). Improvement by at least 4 points was found in 78.8% of patients treated with EGb 761 and in 55.7% of those receiving placebo (p = 0.002). Superiority of EGb 761 over placebo (p < 0.05) was also found for the State‐Trait Anxiety Inventory score, the informants' global impression of change, and both Trail‐Making Test scores. There were statistical trends favoring EGb 761 in the Geriatric Depression Scale and the patients' global impression of change. Adverse events (all non‐serious) were reported by 37 patients taking EGb 761 and 36 patients receiving placebo.ConclusionsEGb 761 improved NPS and cognitive performance in patients with MCI. The drug was safe and well tolerated. Copyright © 2014 John Wiley & Sons, Ltd.
Altered neural function during episodic memory encoding and retrieval in major depression
Authors: Dietsche Bruno , Backes Heidelore , Stratmann Mirjam , Konrad Carsten , Kircher Tilo , Krug Axel 
Published: March 2014

AbstractMemory impairments are common in major depression. Neural processing during non‐emotional episodic memory in depressed patients has only sparsely been investigated, since the majority of studies have focused on emotional stimuli. The aim of this study was to explore neural correlates of episodic memory in depressive patients and to assess brain regions related to subsequent memory performance. Forty‐six participants (23 depressed patients) performed a non‐emotional episodic memory encoding and retrieval task while brain activation was measured with functional magnetic resonance imaging. Patients with depression showed decreased activation in the right prefrontal cortex and right cingulate cortex during memory encoding, but increased activation in the right inferior frontal gyrus (IFG) during recognition memory. While a strong association between hippocampal and parahippocampal activation during memory encoding with subsequent memory performance became evident in healthy controls, this relationship was absent in patients with depression. Taken together, these findings demonstrate that memory related brain regions are affected in their appropriate functioning during memory encoding in depressed patients. Therefore, patients with depression may rely to a greater degree on other brain regions such as the IFG during episodic memory retrieval. Hum Brain Mapp 35:4293–4302, 2014. © 2014 Wiley Periodicals, Inc.