bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic Azimuthal Anisotropy Beneath the Alaska Subduction Zone
Authors: Liu Chuanming , Sheehan Anne F. , Ritzwoller Michael H. 
Published: July 2024

AbstractWe estimate depth‐dependent azimuthal anisotropy and shear wave velocity structure beneath the Alaska subduction zone by the inversion of a new Rayleigh wave dispersion dataset from 8 to 85 s period. We present a layered azimuthal anisotropy model from the forearc region offshore to the subduction zone onshore. In the forearc crust, we find a trench‐parallel pattern in the Semidi and Kodiak segments, while a trench‐oblique pattern is observed in the Shumagins segment. These fast directions agree well with the orientations of local faults. Within the subducted slab, a dichotomous pattern of anisotropy fast axes is observed along the trench, which is consistent with the orientation of fossil anisotropy generated at the mid‐ocean ridges of the Pacific‐Vancouver and Kula‐Pacific plates that is preserved during subduction. Beneath the subducted slab, a trench‐parallel pattern is observed near the trench, which may indicate the direction of mantle flow.
Special Particle Precipitation Signatures Over Giant Auroral Undulations During the 7 September 2015 Geomagnetic Storm
Authors: Zhou Yi‐Jia , He Fei , Zhang Xiao‐Xin , Zhang Yong‐Liang , Liu Libo , Yao Zhong‐Hua , Rong Zhaojin , Wei Yong 
Published: July 2024

AbstractGiant undulations (GUs) have been well established to be the optical manifestation of the plasmapause surface wave (PSW) where the wave‐particle interactions provide particle sources to generate auroras. However, their detailed particles precipitation signatures in the ionosphere remain unclear. Here we analyze multi‐satellite conjugated observations in the ionosphere during a prominent GUs event, revealing the two‐zone precipitation pattern including energetic proton precipitations responsible for the main body of GUs and low‐energy electron precipitations for the edge of GUs. Interestingly, the occurrence of GUs is also accompanied with high‐energy particles precipitations of hundreds of keV and magnetic disturbances of three components. The sizes of sawtooth in the GUs correlate positively with the strength of adjacent subauroral polarization streams (SAPS). The two‐zone precipitation pattern and high‐energy particles precipitation over GUs are potentially related to the plasma sheet and very‐low frequency wave (VLF) modulation of the PSW, respectively.
Small-size temperature/high-pressure integrated sensor via flip-chip method
Authors: Huang Mimi , Wu Xiaoyu , Zhao Libo , Han Xiangguang , Xia Yong , Gao Yi , Cui Zeyu , Zhang Cheng , Yang Xiaokai , Qiao Zhixia , Li Zhikang , Han Feng , Yang Ping , Jiang Zhuangde 
Published: July 2024

AbstractHydraulic technology with smaller sizes and higher reliability trends, including fault prediction and intelligent control, requires high-performance temperature and pressure-integrated sensors. Current designs rely on planar wafer- or chip-level integration, which is limited by pressure range, chip size, and low reliability. We propose a small-size temperature/high-pressure integrated sensor via the flip-chip technique. The pressure and temperature units are arranged vertically, and the sensing signals of the two units are integrated into one plane through silicon vias and gold–gold bonding, reducing the lateral size and improving the efficiency of signal transmission. The flip-chip technique ensures a reliable electrical connection. A square diaphragm with rounded corners is designed and optimised with simulation to sense high pressure based on the piezoresistive effect. The temperature sensing unit with a thin-film platinum resistor measures temperature and provides back-end high-precision compensation, which will improve the precision of the pressure unit. The integrated chip is fabricated by MEMS technology and packaged to fabricate the extremely small integrated sensor. The integrated sensor is characterised, and the pressure sensor exhibits a sensitivity and sensitivity drift of 7.97 mV/MPa and −0.19% FS in the range of 0–20 MPa and −40 to 120 °C. The linearity, hysteresis, repeatability, accuracy, basic error, and zero-time drift are 0.16% FS, 0.04% FS, 0.06% FS, 0.18% FS, ±0.23% FS and 0.04% FS, respectively. The measurement error of the temperature sensor and temperature coefficient of resistance is less than ±1 °C and 3142.997 ppm/°C, respectively. The integrated sensor has broad applicability in fault diagnosis and safety monitoring of high-end equipment such as automobile detection, industrial equipment, and oil drilling platforms.
Clinical features associated with poor response and early relapse following BCMA-directed therapies in multiple myeloma
Authors: Rees Matthew J. , Mammadzadeh Aytaj , Bolarinwa Abiola , Elhaj Mohammed E. , Bohra Arwa , Bansal Radhika , Ailawadhi Sikander , Parrondo Ricardo , Chhabra Saurabh , Khot Amit , Hayman Suzanne , Dispenzieri Angela , Buadi Francis , Dingli David , Warsame Rahma , Kapoor Prashant , Gertz Morie A. , Muchtar Eli , Kourelis Taxiarchis , Gonsalves Wilson , Rajkumar S. Vincent , Lin Yi , Kumar Shaji 
Published: July 2024

AbstractThree classes of BCMA-directed therapy (BDT) exist: antibody drug-conjugates (ADCs), CAR-T, and T-cell engagers (TCEs), each with distinct strengths and weaknesses. To aid clinicians in selecting between BDTs, we reviewed myeloma patients treated at Mayo Clinic with commercial or investigational BDT between 2018-2023. We identified 339 individuals (1-exposure = 297, 2-exposures = 38, 3-exposures = 4) who received 385 BDTs (ADC = 59, TCE = 134, CAR-T = 192), with median follow-up of 21-months. ADC recipients were older, with more lines of therapy (LOT), and penta-refractory disease. Compared to ADCs, CAR-T (aHR = 0.29, 95%CI = 0.20–0.43) and TCEs (aHR = 0.62, 95%CI = 0.43–0.91) had better progression-free survival (PFS) on analysis adjusted for age, the presence of extramedullary (EMD), penta-refractory disease, multi-hit high-risk cytogenetics, prior BDT, and the number of LOT in the preceding 1-year. Likewise, compared to ADCs, CAR-T (aHR = 0.28, 95%CI = 0.18–0.44) and TCEs (aHR = 0.60, 95%CI = 0.39–0.93) had superior overall survival. Prior BDT exposure negatively impacted all classes but was most striking in CAR-T, ORR 86% vs. 50% and median PFS 13-months vs. 3-months. Of relapses, 54% were extramedullary in nature, and a quarter of these cases had no history of EMD. CAR-T demonstrates superior efficacy and where feasible, should be the initial BDT. However, for patients with prior BDT or rapidly progressive disease, an alternative approach may be preferable.
The membrane insertion of the pro-apoptotic protein Bax is a Tom22-dependent multi-step process: a study in nanodiscs
Authors: Rouchidane Eyitayo Akandé , Daury Laetitia , Priault Muriel , Manon Stéphen 
Published: July 2024

AbstractMembrane insertion of the pro-apoptotic protein Bax was investigated by setting up cell-free synthesis of full-length Bax in the presence of pre-formed nanodiscs. While Bax was spontaneously poorly inserted in nanodiscs, co-synthesis with the mitochondrial receptor Tom22 stimulated Bax membrane insertion. The initial interaction of Bax with the lipid bilayer exposed the hydrophobic GALLL motif in Hα1 leading to Bax precipitation through hydrophobic interactions. The same motif was recognized by Tom22, triggering conformational changes leading to the extrusion and the ensuing membrane insertion of the C-terminal hydrophobic Hα9. Tom22 was also required for Bax-membrane insertion after Bax was activated either by BH3-activators or by its release from Bcl-xL by WEHI-539. The effect of Tom22 was impaired by D154Y substitution in Bax-Hα7 and T174P substitution in Bax-Hα9, which are found in several tumors. Conversely, a R9E substitution promoted a spontaneous insertion of Bax in nanodiscs, in the absence of Tom22. Both Tom22-activated Bax and BaxR9E alone permeabilized liposomes to dextran-10kDa and formed ~5-nm-diameter pores in nanodiscs. The concerted regulation of Bax membrane insertion by Tom22 and BH3-activators is discussed.
Home blood pressure-lowering effect of a non-steroidal mineralocorticoid receptor blocker, esaxerenone, versus trichlormethiazide for uncontrolled hypertension: the EXCITE-HT randomized controlled study
Authors: Kario Kazuomi , Ohbayashi Hiroyuki , Hashimoto Masami , Itabashi Naoki , Kato Mitsutoshi , Uchiyama Kazuaki , Hirano Kunio , Nakamura Noriko , Miyamoto Takahide , Nagashima Hirotaka , Kajiyama Shizuo , Ishida Hidenori , Imai Enyu , Ebe Yusuke , Ohishi Mitsuru , Katsuya Tomohiro , Taguchi Takashi , Tanabe Ayumi , Shimosawa Tatsuo ,   on behalf of the EXCITE-HT investigators
Published: July 2024

AbstractThe EXCITE-HT study aimed to evaluate the efficacy and safety of esaxerenone versus thiazide diuretics (trichlormethiazide) as second-line treatment for Japanese patients with uncontrolled essential hypertension. This was a 12-week, multicenter, randomized, open-label, parallel-group study. The non-inferiority of esaxerenone to trichlormethiazide was confirmed if the upper limit of the two-sided 95% confidence interval (CI) for the difference in systolic blood pressure (SBP)/diastolic blood pressure (DBP) change between groups was below 3.9/2.1 mmHg. A total of 295 and 290 patients were included in the esaxerenone and trichlormethiazide groups, respectively. The non-inferiority of esaxerenone to trichlormethiazide was demonstrated: least squares mean change differences in morning home SBP/DBP at end of treatment (EOT) were −2.2 (95% CI, −3.6, −0.8) mmHg for SBP/−0.6 (−1.4, 0.2) mmHg for DBP. Morning home, bedtime home, and office BP significantly decreased (all p < 0.001) from baseline to EOT in both groups. The urinary albumin-to-creatinine ratio and N-terminal pro-brain natriuretic peptide level decreased from baseline to Week 12 in both groups, with no notable intergroup difference. Serum potassium elevations occurred more frequently with esaxerenone, while serum potassium reductions occurred more with trichlormethiazide. Uric acid elevations were observed in both groups, but more frequently with trichlormethiazide than esaxerenone. No cases of gout occurred in this study. Reductions in estimated glomerular filtration rate were similarly observed in both groups. EXCITE-HT is the first randomized controlled study to demonstrate evidence that esaxerenone is non-inferior to trichlormethiazide as second-line treatment for Japanese patients with uncontrolled essential hypertension, with no new safety concerns.
PARP10 promotes the repair of nascent strand DNA gaps through RAD18 mediated translesion synthesis
Authors: Khatib Jude B. , Dhoonmoon Ashna , Moldovan George-Lucian , Nicolae Claudia M. 
Published: July 2024

AbstractReplication stress compromises genomic integrity. Fork blocking lesions such as those induced by cisplatin and other chemotherapeutic agents arrest replication forks. Repriming downstream of these lesions represents an important mechanism of replication restart, however the single stranded DNA (ssDNA) gaps left behind, unless efficiently filled, can serve as entry point for nucleases. Nascent strand gaps can be repaired by BRCA-mediated homology repair. Alternatively, gaps can also be filled by translesion synthesis (TLS) polymerases. How these events are regulated is still not clear. Here, we show that PARP10, a poorly-characterized mono-ADP-ribosyltransferase, is recruited to nascent strand gaps to promote their repair. PARP10 interacts with the ubiquitin ligase RAD18 and recruits it to these structures, resulting in the ubiquitination of the replication factor PCNA. PCNA ubiquitination, in turn, recruits the TLS polymerase REV1 for gap filling. We show that PARP10 recruitment to gaps and the subsequent REV1-mediated gap filling requires both the catalytic activity of PARP10, and its ability to interact with PCNA. We moreover show that PARP10 is hyperactive in BRCA-deficient cells, and its inactivation potentiates gap accumulations and cytotoxicity in these cells. Our work uncovers PARP10 as a regulator of ssDNA gap filling, which promotes genomic stability in BRCA-deficient cells.
Metal-organic framework derived crystalline nanocarbon for Fenton-like reaction
Authors: Lian Tingting , Xu Li , Piankova Diana , Yang Jin-Lin , Tarakina Nadezda V. , Wang Yang , Antonietti Markus 
Published: July 2024

AbstractNanoporous carbons with tailorable nanoscale texture and long-range ordered structure are promising candidates for energy, environmental and catalytic applications, while the current synthetic methods do not allow elaborate control of local structure. Here we report a salt-assisted strategy to obtain crystalline nanocarbon from direct carbonization of metal-organic frameworks (MOFs). The crystalline product maintains a highly ordered two-dimensional (2D) stacking mode and substantially differs from the traditional weakly ordered patterns of nanoporous carbons upon high-temperature pyrolysis. The MOF-derived crystalline nanocarbon (MCC) comes with a high level of nitrogen and oxygen terminating the 2D layers and shows an impressive performance as a carbocatalyst in Fenton-like reaction for water purification. The successful preparation of MCC illustrates the possibility to discover other crystalline heteroatom-doped carbon phases starting from correctly designed organic precursors and appropriate templating reactions.
Aqueous alternating electrolysis prolongs electrode lifespans under harsh operation conditions
Authors: Liang Jie , Li Jun , Dong Hongliang , Li Zixiaozi , He Xun , Wang Yan , Yao Yongchao , Ren Yuchun , Sun Shengjun , Luo Yongsong , Zheng Dongdong , Li Jiong , Liu Qian , Luo Fengming , Wu Tongwei , Chen Guang , Sun Xuping , Tang Bo 
Published: July 2024

AbstractIt is vital to explore effective ways for prolonging electrode lifespans under harsh electrolysis conditions, such as high current densities, acid environment, and impure water source. Here we report alternating electrolysis approaches that realize promptly and regularly repair/maintenance and concurrent bubble evolution. Electrode lifespans are improved by co-action of Fe group elemental ions and alkali metal cations, especially a unique Co2+-Na+ combo. A commercial Ni foam sustains ampere-level current densities alternatingly during continuous electrolysis for 93.8 h in an acidic solution, whereas such a Ni foam is completely dissolved in ~2 h for conventional electrolysis conditions. The work not only explores an alternating electrolysis-based system, alkali metal cation-based catalytic systems, and alkali metal cation-based electrodeposition techniques, and beyond, but demonstrates the possibility of prolonged electrolysis by repeated deposition-dissolution processes. With enough adjustable experimental variables, the upper improvement limit in the electrode lifespan would be high.
Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition
Authors: Wang Liang , Yang Ziyun , Satoshi Fudo , Prasanna Xavier , Yan Ziyi , Vihinen Helena , Chen Yaxing , Zhao Yue , He Xiumei , Bu Qian , Li Hongchun , Zhao Ying , Jiang Linhong , Qin Feng , Dai Yanping , Zhang Ni , Qin Meng , Kuang Weihong , Zhao Yinglan , Jokitalo Eija , Vattulainen Ilpo , Kajander Tommi , Zhao Hongxia , Cen Xiaobo 
Published: July 2024

AbstractThe Bin/Amphiphysin/Rvs (BAR) domain protein FAM92A1 is a multifunctional protein engaged in regulating mitochondrial ultrastructure and ciliogenesis, but its physiological role in the brain remains unclear. Here, we show that FAM92A1 is expressed in neurons starting from embryonic development. FAM92A1 knockout in mice results in altered brain morphology and age-associated cognitive deficits, potentially due to neuronal degeneration and disrupted synaptic plasticity. Specifically, FAM92A1 deficiency impairs diverse neuronal membrane morphology, including the mitochondrial inner membrane, myelin sheath, and synapses, indicating its roles in membrane remodeling and maintenance. By determining the crystal structure of the FAM92A1 BAR domain, combined with atomistic molecular dynamics simulations, we uncover that FAM92A1 interacts with phosphoinositide- and cardiolipin-containing membranes to induce lipid-clustering and membrane curvature. Altogether, these findings reveal the physiological role of FAM92A1 in the brain, highlighting its impact on synaptic plasticity and neural function through the regulation of membrane remodeling and endocytic processes.
Long-term risk of autoimmune diseases after mRNA-based SARS-CoV2 vaccination in a Korean, nationwide, population-based cohort study
Authors: Jung Seung-Won , Jeon Jae Joon , Kim You Hyun , Choe Sung Jay , Lee Solam 
Published: July 2024

AbstractThe long-term association between mRNA-based coronavirus disease 2019 (COVID-19) vaccination and the development of autoimmune connective tissue diseases (AI-CTDs) remains unclear. In this nationwide, population-based cohort study involving 9,258,803 individuals, we aim to determine whether the incidence of AI-CTDs is associated with mRNA vaccination. The study spans over 1 year of observation and further analyses the risk of AI-CTDs by stratifying demographics and vaccination profiles and treating booster vaccination as time-varying covariate. We report that the risk of developing most AI-CTDs did not increase following mRNA vaccination, except for systemic lupus erythematosus with a 1.16-fold risk in vaccinated individuals relative to controls. Comparable results were reported in the stratified analyses for age, sex, mRNA vaccine type, and prior history of non-mRNA vaccination. However, a booster vaccination was associated with an increased risk of some AI-CTDs including alopecia areata, psoriasis, and rheumatoid arthritis. Overall, we conclude that mRNA-based vaccinations are not associated with an increased risk of most AI-CTDs, although further research is needed regarding its potential association with certain conditions.
A possible path to persistent re-entry waves at the outlet of the left pulmonary vein
Authors: Jæger Karoline Horgmo , Tveito Aslak 
Published: July 2024

AbstractAtrial fibrillation (AF) is the most common form of cardiac arrhythmia, often evolving from paroxysmal episodes to persistent stages over an extended timeframe. While various factors contribute to this progression, the precise biophysical mechanisms driving it remain unclear. Here we explore how rapid firing of cardiomyocytes at the outlet of the pulmonary vein of the left atria can create a substrate for a persistent re-entry wave. This is grounded in a recently formulated mathematical model of the regulation of calcium ion channel density by intracellular calcium concentration. According to the model, the number of calcium channels is controlled by the intracellular calcium concentration. In particular, if the concentration increases above a certain target level, the calcium current is weakened to restore the target level of calcium. During rapid pacing, the intracellular calcium concentration of the cardiomyocytes increases leading to a substantial reduction of the calcium current across the membrane of the myocytes, which again reduces the action potential duration. In a spatially resolved cell-based model of the outlet of the pulmonary vein of the left atria, we show that the reduced action potential duration can lead to re-entry. Initiated by rapid pacing, often stemming from paroxysmal AF episodes lasting several days, the reduction in calcium current is a critical factor. Our findings illustrate how such episodes can foster a conducive environment for persistent AF through electrical remodeling, characterized by diminished calcium currents. This underscores the importance of promptly addressing early AF episodes to prevent their progression to chronic stages.
Effects of brief remote high ventilation breathwork with retention on mental health and wellbeing: a randomised placebo-controlled trial
Authors: Fincham Guy W. , Epel Elissa , Colasanti Alessandro , Strauss Clara , Cavanagh Kate 
Published: July 2024

AbstractHigh ventilation breathwork with retention (HVBR) has been growing in popularity over the past decade and might be beneficial for mental and physical health. However, little research has explored the potential therapeutic effects of brief, remotely delivered HVBR and the tolerability profile of this technique. Accordingly, we investigated the effects of a fully-automated HVBR protocol, along with its tolerability, when delivered remotely in a brief format. This study (NCT06064474) was the largest blinded randomised-controlled trial on HVBR to date in which 200 young, healthy adults balanced for gender were randomly allocated in blocks of 2 by remote software to 3 weeks of 20 min daily HVBR (fast breathing with long breath holds) or a placebo HVBR comparator (15 breaths/min with short breath holds). The trial was concealed as a ‘fast breathwork’ study wherein both intervention and comparator were masked, and only ~ 40% guessed their group assignment with no difference in accuracy between groups. Both groups reported analogous credibility and expectancy of benefit, subjective adherence, positive sentiment, along with short- and long-term tolerability. At post-intervention (primary timepoint) for stress level (primary outcome), we found no significant group × time interaction, F(1,180) = 1.98, p = 0.16, ηp2 = 0.01, d = 0.21), nor main effect of group, (F = 0.35, p = 0.55, ηp2 < 0.01) but we did find a significant main effect of time, (F = 13.0, p < 0.01, ηp2 = 0.07). There was a significant improvement in stress pre-post-intervention in both groups, however there was no significant difference in such improvement between groups. In addition to stress at follow-up, we found no significant group x time interactions for secondary trait outcomes of anxiety, depression, mental wellbeing, and sleep-related impairment. This was also the case for state positive and negative affect after the first session of breathwork and at post-intervention. Brief remote HVBR therefore may not be more efficacious at improving mental health than a well-designed active comparator in otherwise healthy, young adults.
Target control of linear directed networks based on the path cover problem
Authors: Someya Wataru , Akutsu Tatsuya , Nacher Jose C. 
Published: July 2024

AbstractSecuring complete control of complex systems comprised of tens of thousands of interconnected nodes holds immense significance across various fields, spanning from cell biology and brain science to human-engineered systems. However, depending on specific functional requirements, it can be more practical and efficient to focus on a pre-defined subset of nodes for control, a concept known as target control. While some methods have been proposed to find the smallest driver node set for target control, they either rely on heuristic approaches based on k-walk theory, lacking a guarantee of optimal solutions, or they are overly complex and challenging to implement in real-world networks. To address this challenge, we introduce a simple and elegant algorithm, inspired by the path cover problem, which efficiently identifies the nodes required to control a target node set within polynomial time. To practically apply the algorithm in real-world systems, we have selected several networks in which a specific set of nodes with functional significance can be designated as a target control set. The analysed systems include the complete connectome of the nematode worm C. elegans, the recently disclosed connectome of the Drosophila larval brain, as well as dozens of genome-wide metabolic networks spanning major plant lineages. The target control analysis shed light on distinctions between neural systems in nematode worms and larval brain insects, particularly concerning the number of nodes necessary to regulate specific functional systems. Furthermore, our analysis uncovers evolutionary trends within plant lineages, notably when examining the proportion of nodes required to control functional pathways.