bluuebunny/crossref_metadata_2025_split huggingface dataset:
Easternmost Mediterranean evidence of the Zanclean flooding event and subsequent surface uplift: Adana Basin, southern Turkey
Authors: Cipollari Paola , Cosentino Domenico , Radeff Giuditta , Schildgen Taylor F. , Faranda Costanza , Grossi Francesco , Gliozzi Elsa , Smedile Alessandra , Gennari Rocco , Darbaş Güldemin , Dudas Francis Ö. , Gürbüz Kemal , Nazik Atike , Echtler Helmut 
Published: September 2012

Abstract

According to the literature, the Adana Basin, at the easternmost part of the Mediterranean Basin in southern Turkey, records the Pliocene stage with shallow-marine to fluvial deposits. Our micropalaeontological analysis of samples from the Adana Basin reveal Late Lago–Mare biofacies with Paratethyan ostracod assemblages pertaining to the
Loxocorniculina djafarovi
zone. Grey clays rich in planktonic foraminifera lie above the Lago–Mare deposits. Within the grey clays, the continuous occurrence of the calcareous nannofossil
Reticulofenestra zancleana
and the base of the
Reticulofenestra pseudoumbilicus
paracme points to an Early Zanclean age (5.332–5.199 Ma). Both ostracod and benthic foraminifera indicate epibathyal and bathyal environments.
87
Sr/
86
Sr measurements on planktonic and benthic foraminifera fall below the mean global ocean value for the Early Zanclean, indicating potentially insufficient mixing of low
87
Sr/
86
Sr Mediterranean brackish ‘Lago–Mare’ water with the global ocean in the earliest Pliocene. We utilize the ages and palaeodepths of the marine sediments together with their modern elevations to determine uplift rates of the Adana Basin of 0.06 to 0.13 mm a
−1
since 5.2–5.3 Ma (total uplift of 350–650 m) from surface data, and 0.02–0.13 mm a
−1
since
c.
1.8 Ma (total uplift of 30–230 m) from subsurface data.

Supplementary material:

Microphotographs of foraminifers, ostracods, and calcareous nannofossils, plots of the calcareous nannofossil frequencies, occurrence of foraminifers and ostracods in the study sections, results of Sr isotopic analysis, and a complete list of fossils are available at
www.geolsoc.org.uk/SUP18535
.
Upper Miocene–Pleistocene deformation of the Girne (Kyrenia) Range and Dar Dere (Ovgos) lineaments, northern Cyprus: role in collision and tectonic escape in the easternmost Mediterranean region
Authors: McCay G. A. , Robertson A. H. F. 
Published: September 2012

Abstract

During Late Cretaceous–Mid-Eocene the Girne (Kyrenia) Range formed part of the northerly active continental margin of the southern Neotethys. Following Late Eocene–Late Miocene mainly deep-marine clastic deposition, the range was thrust southwards in a convergent (transpressional) stress regime during Late Miocene (Messinian)–earliest Pliocene time. Sinistral transpression is most evident near the front of the range in the east and in several segments, implying strain compartmentalization. The range was relatively quiescent during Early–Mid Pliocene, followed by strong
c.
east–west-trending uplift during Late Pliocene–Pleistocene. Further south, the east–west Dar Dere (Ovgos) lineament was active as a north-down extensional (or transtensional) fault zone during Oligocene–Mid-Miocene. Sinistral strike-slip/transpression followed during Late Miocene, followed by strike-slip at least during Late Pliocene–Pleistocene. The latest Miocene–earliest Pliocene thrusting/oblique convergence reflects closure of the southern Neotethys and tightening of the suture between the Arabian (North African) and Turkish (Eurasian) continents. Collision-related uplift of the Girne (Kyrenia) Range and the Troodos Massif further south took place from Late Pliocene time onwards. The Dar Dere (Ovgos) lineament is interpreted as a terrane boundary that was reactivated related to westward tectonic escape of Anatolia during Neogene–Recent time. The structure as a whole reflects regional diachronous continental collision.

Supplementary material:

Detailed geological maps of key areas to the south and north of the Girne (Kyrenia) Range based on regional mapping and field observations are available at
www.geolsoc.org.uk/SUP18534
.
What can we learn from high-resolution numerical simulations of single- and multi-phase fluid flow in fractured outcrop analogues?
Authors: Geiger Sebastian , Matthäi Stephan 
Published: September 2012

Abstract
Naturally fractured reservoirs (NFR), such as the large carbonate reservoirs in the Middle East, contain a major part of the world's remaining conventional oil reserves, but recovering these is especially challenging as the fractures only constitute fluid conduits while the oil is trapped in a low-permeability rock matrix. Recovery factors are therefore difficult to estimate, permeability anisotropy is high, size and shape of drainage areas are difficult to constrain, early water breakthrough is likely to be associated with a high and irreversible water cut, and secondary recovery behaviour is unusual. Outcrop-analogue model-based discrete fracture and matrix (DFM) simulations have emerged recently, helping us to disentangle and rationalize this erratic production behaviour. They allow us to understand the emergent flow behaviour and resulting saturation patterns in NFRs. Thus, classical simulation approaches, such as dual-continua conceptualizations, can be critically evaluated and improved where they fail to capture the flow behaviour of interest.
This paper discusses recent advances in DFM simulation of single- and multi-phase flow processes in geologically realistic outcrop-analogue models, and solved with finite-element (FE) and finite-volume (FV) methods. It also reviews key results from recent DFM simulation studies, in particular how new measures such as the fracture–matrix flux ratio and velocity spectra can provide new means to analyse flow behaviour in heterogeneous domains or how results from outcrop-based simulations can be used to test the suitability of conventional upscaling approaches for NFR and guide the development of new ones. We close by enlisting outstanding challenges in outcrop-based flow simulations such as the need to capture the fracture–matrix transfer processes due to capillary, gravity and viscous forces accurately, which often implies detailed grid refinement at the fracture–matrix interface and small time-steps to resolve the physical processes adequately. Thus, we explore how outcrop-based flow simulation could be applied more routinely in NFR reservoir characterization and simulation workflows.
Cervical Cancer Burden and Prevention Strategies: Asia Oceania Perspective
Authors: Garland Suzanne M. , Bhatla Neerja , Ngan Hextan Y.S. 
Published: September 2012

Abstract
The Asia Oceania region contributes to more than 50% of cervical cancer cases worldwide. Yet cervical cancer is one of few cancers that can be prevented through comprehensive screening for precancerous lesions, with their subsequent treatment. Screening with cervical cytology, a very old technology, has reduced cervical cancer mortality and incidence when applied in comprehensive programs with high coverage and high quality assurance. However, of those countries within this region that have set up such programs, many have been opportunistic, had poor coverage, or inadequate treatment facilities for lesions found. Consequently, they have not seen large reductions in cancer incidence or mortality. Some have therefore adopted visual inspection by acetic acid (VIA) and Lugol's iodine (VILI) or human papillomavirus (HPV) DNA assays for screening.
With two safe, immunogenic and efficacious prophylactic vaccines licensed, the way forward to reduction of cervical cancer to becoming uncommon is within reach. Where governments have supported high coverage public-health vaccination programs, reductions in disease burden with shortest incubation (genital warts, high-grade abnormalities) are already being reported. One of the biggest impediments is the cost of vaccines that are affordable to resource-poor countries. Other challenges include, infrastructure for delivery of vaccines, plus general acceptance of vaccination by the community. Cancer Epidemiol Biomarkers Prev; 21(9); 1414–22. ©2012 AACR.
Insulin-like Growth Factor-I Concentration and Risk of Prostate Cancer: Results from the European Prospective Investigation into Cancer and Nutrition
Authors: Price Alison J. , Allen Naomi E. , Appleby Paul N. , Crowe Francesca L. , Travis Ruth C. , Tipper Sarah J. , Overvad Kim , Grønbæk Henning , Tjønneland Anne , Johnsen Nina Føns , Rinaldi Sabina , Kaaks Rudolf , Lukanova Annie , Boeing Heiner , Aleksandrova Krasimira , Trichopoulou Antonia , Trichopoulos Dimitrios , Andarakis George , Palli Domenico , Krogh Vittorio , Tumino Rosario , Sacerdote Carlotta , Bueno-de-Mesquita H. Bas , Argüelles Marcial V. , Sánchez Maria-José , Chirlaque Maria-Dolores , Barricarte Aurelio , Larrañaga Nerea , González Carlos A. , Stattin Pär , Johansson Mattias , Khaw Kay-Tee , Wareham Nick , Gunter Marc , Riboli Elio , Key Timothy 
Published: September 2012

Abstract
Background: High circulating insulin-like growth factor-I (IGF-I) concentrations have been associated with increased risk for prostate cancer in several prospective epidemiological studies. In this study, we investigate the association between circulating IGF-I concentration and risk of prostate cancer over the long term in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Methods: In a nested case–control design, 1,542 incident prostate cancer cases from eight European countries were individually matched to 1,542 controls by study center, age at recruitment, duration of follow-up, time of day, and duration of fasting at blood collection. Conditional logistic regression models were used to calculate risk for prostate cancer associated with IGF-I concentration, overall and by various subgroups.
Results: Circulating IGF-I concentration was associated with a significant increased risk for prostate cancer [OR for highest vs. lowest quartile, 1.69; 95% confidence interval (CI), 1.35–2.13; Ptrend = 0.0002]. This positive association did not differ according to duration of follow-up [ORs for highest vs. lowest quartile were 2.01 (1.35–2.99), 1.37 (0.94–2.00), and 1.80 (1.17–2.77) for cancers diagnosed &lt;4, 4—7, and &gt;7 years after blood collection, respectively (Pheterogeneity = 0.77)] or by stage, grade, and age at diagnosis or age at blood collection (all subgroups Pheterogeneity &gt;0.05).
Conclusion: In this European population, high circulating IGF-I concentration is positively associated with risk for prostate cancer over the short and long term.
Impact: As IGF-I is the only potentially modifiable risk factor so far identified, research into the effects of reducing circulating IGF-I levels on subsequent prostate cancer risk is warranted. Cancer Epidemiol Biomarkers Prev; 21(9); 1531–41. ©2012 AACR.
Tympanoplasty for Blast‐Induced Perforations
Authors: Sridhara Shankar K. , Rivera Arnaldo , Littlefield Philip 
Published: September 2012

ObjectiveTo review our tympanoplasty results for blast‐induced tympanic membrane perforations and evaluate the association of various clinical factors with surgical success.Study DesignCase series with chart review.SettingTwo tertiary military healthcare institutions.MethodsThis is a retrospective review of all patients who had nonrevision tympanoplasty during a 1‐year period for blast‐induced perforations by the 2 neurotologists at Walter Reed Army Medical Center and National Naval Medical Center. Various perioperative clinical factors were analyzed for relations to successful perforation closure, the need for a second operation, and postoperative hearing.ResultsThirty‐four patients met inclusion criteria. All were male, and the average age was 24.0 years. Twenty‐two (65%) were total or near‐total perforations, of which 12 (35%) were repaired using lateral graft technique. The remainder had various medial graft procedures. Ossicular abnormalities were found in 6 (18%) patients. Cholesteatoma was discovered in 3 (9%) patients. Closure was complete in 82% of patients. The incomplete closures were with large perforations, those with foreign bodies (shrapnel), and in 1 with postoperative water exposure. There were no major complications, and the mean conductive hearing improvement was 11.3 dB.ConclusionBlast‐induced tympanic membrane perforations are common in our population of wounded warriors. These cases are challenging because most have total or near‐total perforations, the ossicles can be out of place, the blast itself can implant epithelium in the middle ear, and foreign bodies can create a hostile middle ear environment. However, given attention to detail, we found that standard tympanoplasty techniques work well.
Reducing falls among geriatric rehabilitation patients: a controlled clinical trial
Authors: Vieira Edgar Ramos , Berean Colleen , Paches Debra , Caveny Penny , Yuen Doris , Ballash Lauralee , Freund-Heritage Rosalie 
Published: September 2012

Objective: To evaluate the effectiveness of an intervention programme to reduce falls among geriatric rehabilitation patients. Design: Pre/post-test design with independent pre-test and matched post-test samples. Setting: Inpatient geriatric wards in a rehabilitation hospital. Participants: Seventy-six matched pairs ( n = 152) of geriatric rehabilitation patients from one control and one intervention ward participated in the study, and 36 nursing staff surveys were completed. Intervention: The intervention programme was developed based on interviews and systematic reviews. Educational materials were distributed to patients and families, and preventive measures were implemented. Main outcome measures: The rates of falls before and after the intervention both within and between the wards were compared, and surveys were completed. Results: The matched patients presented no significant differences on age, gender or medical conditions. The falls rates, proportion of fallers and length of stay was higher among those in the control ward ( P< 0.043). The percentage of fallers and the rate of falls/1000 patient days were lower on the intervention ward after implementation: odds ratio (95% confidence interval) = −2.9 (−6.6, −1.2) and −1.8 (−6.0, 0.5). Thirty of 36 respondents considered the tool to be helpful and beneficial for use on other wards. Conclusion: The intervention programme was effective in reducing falls among geriatric rehabilitation patients.
‘How can we tell it to the children?’ A deliberation at the Institute of Social Research
Authors: Kettler David , Wheatland Thomas 
Published: September 2012

To introduce an archival protocol of a ‘Debate about methods in the social sciences, especially the conception of social science method represented by the Institute’, held on 17 January 1941 at the Institute of Social Research in New York, the article focuses on certain conflicts in substance and terms of discourse among members of the Institute, with special emphasis on Franz Neumann’s distinctive approaches, notwithstanding his professed loyalty to Max Horkheimer’s theory. These are seen to arise not only from Neumann’s assignment as bargaining agent for the Institute and his distinctive relations with American colleagues, but also from their different orientations to the conflicted legacies of Weimar.
Racial/Ethnic Perspectives on the Quality of Hospice Care
Authors: Campbell Cathy L. , Baernholdt Marianne , Yan Guofen , Hinton Ivora D. , Lewis Erica 
Published: September 2012

Diversity in the US population is increasing, and evaluating the quality of culturally sensitive hospice care is important. A survey design was used to collect data from 743 patients enrolled in hospice or their family members or caregivers. Race/ethnicity was not significantly associated with any of the hospice interventions or outcomes. Patients were less likely to be satisfied with the overall hospice care (OR = 0.23, 95% CI = 0.065-0.796, P = .021) compared to other type of respondents. Satisfaction with emotional support was substantially associated with the increased likelihood of satisfaction with pain management (OR = 3.82, 95% CI = 1.66-8.83, P = .002), satisfaction with other symptom management (OR = 6.17, 95% CI = 2.80-13.64, P < .001), and of overall satisfaction with hospice care (OR = 20.22, 95% CI = 8.64-47.35, P < .001).
The Impact of a Palliative Care Program in a Rural Appalachian Community Hospital
Authors: Armstrong Bernita , Jenigiri Bharat , Hutson Sadie P. , Wachs Peter M. , Lambe Camille Eckerd 
Published: September 2012

Background: Hospital inpatient palliative care consultation services (PCCSs) provide high-quality, comprehensive care for seriously ill patients and their families. The objective of the Palliative Care Impact Study was to evaluate the impact of a PCCS in a rural Appalachian community hospital in 4 domains: clinical, customer, operational, and financial. Methods and Results: A nonrandomized preintervention–postintervention study enrolled 25 patients. We collected data in the 4 domains listed above after a palliative care (PC) consultation and compared them with preconsultation data. Findings demonstrated a statistically significant improvement in pain and symptom burden scores; customer metrics produced an excellent rating of 88.5% by patients and families and physician/providers; with an associated cost savings of $521 per patient per day after PC consultation was complete.
Darexaban for the Prevention of Venous Thromboembolism in Asian Patients Undergoing Orthopedic Surgery
Authors: Fuji Takeshi , Nakamura Mashio , Takeuchi Masahiro 
Published: September 2012

Objective: To evaluate the efficacy and safety of darexaban (YM150) in Asian patients undergoing total hip or total knee arthroplasty. Methods: In 2 phase II/III multicenter, randomized, double-blind, placebo-controlled, parallel-group studies, patients were randomized to oral darexaban 15 mg twice daily (bid), darexaban 30 mg bid, oral placebo bid, or subcutaneous enoxaparin 20 mg bid. Primary efficacy outcome for both studies was total venous thromboembolism (VTE) incidence. Results: Both darexaban doses were statistically significantly superior to placebo for total VTE incidence (hip study: darexaban 15 mg bid [2.9%] vs placebo [17.1%], P < .001; darexaban 30 mg bid [5.2%] vs placebo [17.1%], P = .003; and knee study: darexaban 15 mg bid [27.2%] vs placebo [52.8%], P = .002; darexaban 30 mg bid [15.5%] vs placebo [52.8%], P < .001). In both studies, the incidence of bleeding events was low across all treatment groups. Conclusion: Darexaban is effective and well tolerated as VTE prophylaxis in Asian patients undergoing elective major orthopedic surgery.
Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia
Authors: Daridon Capucine , Loddenkemper Christoph , Spieckermann Simone , Kühl Anja A. , Salama Abdulgabar , Burmester Gerd R. , Lipsky Peter E. , Dörner Thomas 
Published: September 2012

Abstract
To understand more specific abnormalities of humoral autoimmunity, we studied 31 spleens from immune thrombocytopenia (ITP) patients and 36 control spleens. Detailed analysis identified at least 2 different splenic structures accommodating proliferating B cells, classic germinal centers (GCs), and proliferative lymphoid nodules (PLNs). PLNs were characterized by proliferating Ki67+ B cells close to follicular dendritic cells (FDCs) and lacked polarization into dark and light zones. As opposed to cells in GCs, proliferating B cells in PLN lacked expression of Bcl6. In both PLNs and GCs of ITP spleens, the density of T cells was significantly reduced. Both T follicular helper cells (TFH) and regulatory T cells were reduced within PLNs of ITP spleens suggesting a defect of tolerance related to a loss of T-cell control. Within PLNs of ITP, but not controls, abundant platelet glycoprotein (GP) IIb/IIIa autoantigens was found in IgM containing immune complexes tightly bound to FDCs and closely approximated to proliferating B cells. GPIV was found less often, but not in the same PLNs as GPIIb/IIIa. Autoantigens were not found in the GCs of ITP or controls indicating that PLNs are the sites of autoantigen stimulation in ITP potentially related to a lack of control by T cells and/or the present autoantigen.
Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma
Authors: Steidl Christian , Diepstra Arjan , Lee Tang , Chan Fong Chun , Farinha Pedro , Tan King , Telenius Adele , Barclay Lorena , Shah Sohrab P. , Connors Joseph M. , van den Berg Anke , Gascoyne Randy D. 
Published: September 2012

Abstract
In classical Hodgkin lymphoma (CHL), 20%-30% of patients experience relapse or progressive disease after initial treatment. The pathogenesis and biology of treatment failure are still poorly understood, in part because the molecular phenotype of the rare malignant Hodgkin Reed-Sternberg (HRS) cells is difficult to study. Here we examined microdissected HRS cells from 29 CHL patients and 5 CHL-derived cell lines by gene expression profiling. We found significant overlap of HL-specific gene expression in primary HRS cells and HL cell lines, but also differences, including surface receptor signaling pathways. Using integrative analysis tools, we identified target genes with expression levels that significantly correlated with genomic copy-number changes in primary HRS cells. Furthermore, we found a macrophage-like signature in HRS cells that significantly correlated with treatment failure. CSF1R is a representative of this signature, and its expression was significantly associated with progression-free and overall survival in an independent set of 132 patients assessed by mRNA in situ hybridization. A combined score of CSF1R in situ hybridization and CD68 immunohistochemistry was an independent predictor for progression-free survival in multivariate analysis. In summary, our data reveal novel insights into the pathobiology of treatment failure and suggest CSF1R as a drug target of at-risk CHL.