bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of Herlyn–Werner–Wunderlich syndrome with exacerbation of hematometra after adnexectomy
Authors: Hayashi Shigehiro , Ono Masanori , Sagisaka Masahiro , Mimura Takayuki , Kojima Junya , Ono Masataka , Sasaki Toru , Yamamoto Akiko , Nishi Hirotaka 
Published: July 2024

AbstractA 27‐year‐old nulliparous woman presented with a feeling of fullness in the lower abdomen and abdominal pain. A left ovarian tumor, uterus didelphys, left renal agenesis, and left vaginal atresia were observed on imaging. The ovarian tumor was presumed to have caused the abdominal pain, and an abdominal left adnexectomy was performed. After 3 months, she reported severe lower abdominal pain during menstruation. Transvaginal ultrasonography revealed uterine enlargement. After 17 days, the patient presented with abdominal pain and fever. She was diagnosed with peritonitis due to infection and left uterine hematometra. Because she did not improve with antibiotic treatment, left laparoscopic hysterectomy was performed. Subsequently, she did not experience the lower abdominal pain. Appropriate diagnosis and treatment based on the morphology of the reproductive tract and symptoms must be considered in patients with Herlyn–Werner–Wunderlich syndrome. Treatment must permit the outflow of menstrual blood.
Design of a pharmacokinetic/pharmacodynamic model for administration of low dose peripheral norepinephrine during general anaesthesia
Authors: Joachim Jona , Cartailler Jérôme , Vallee Fabrice , Lefevre Thomas , Callebert Jacques , Gayat Etienne , Lavielle Marc 
Published: July 2024

AimsIntraoperative hypotension is a risk factor for kidney, heart and cognitive postoperative complications. Literature suggests that the use of low‐dose peripheral norepinephrine (NOR) reduces organ dysfunction, yet its administration remains unstandardized. In this work we develop a pharmacokinetic (PK)/pharmacodynamic (PD) model of NOR and its effect on mean arterial pressure (MAP).MethodsFrom June 2018 to December 2021, we included patients scheduled for elective neurosurgery and requiring vasopressors for intraoperative hypotension management at Lariboisière Hospital, Paris. Low doses of NOR were administered peripherally, and successive arterial blood samples were collected to track its plasmatic concentration. We used a compartmental modelling approach for NOR PK. We developed and compared 2 models for NOR PD on MAP. Model comparison was done using Bayes information criteria. The resulting PK/PD model parameters were fitted over the entire population and linked to age, weight, height and sex.ResultsWe included 29 patients (age 52 [46–64] years, 69% female). NOR median time to peak effect on MAP was 74 [53–94] s. After bolus administration, MAP increased by 24% (15–31%). A 2‐comparment model with depot best captured NOR PK. NOR PD effect on MAP was well represented by both Emax and Windkessel models, with better results for the former. We found that age, height and weight as well as history of smoking and hypertension were correlated with model parameters.ConclusionWe have developed a PK/PD model to accurately track norepinephrine plasma concentration and its effect on MAP over time, which could serve for target‐controlled infusion.
Clinical characteristics and prognosis of liver injury induced by immune checkpoint inhibitors in patients with malignancies: A real‐world retrospective study
Authors: Jiang Ying , Lv Minzhi , Jin Zhiping , Wu Yi , Li Xiaoyu , Zhang Ningping 
Published: July 2024

AimsProgrammed cell death receptor (ligand)‐1 inhibitors (PD‐(L)1), as the preferred immunotherapy, have been widely used in the Chinese mainland and drug‐induced liver injury (DILI) has been reported. The study aimed to investigate the clinical features or risk factors for immunotherapy‐related DILI.MethodsPatients who received PD‐(L)1 inhibitors from January 2020 to July 2021 were retrospectively reviewed. The likelihood of DILI was adjudicated by the Roussel‐Uclaf causality assessment.ResultsA total of 1175 patients were included in the study and 89 patients (7.6%) developed DILI, of which 12 (13.5%) progressed to acute liver failure (ALF) and three (3.4%) died. Among the DILI population, 56 (62.9%) had a cholestatic pattern and exhibited a prolonged treatment course and duration for resolution compared to the hepatocellular and mixed patterns. Hepatocellular carcinoma (HCC), hepatitis B virus (HBV) and abnormal baseline of alkaline phosphatase (ALP) had increased risks of DILI by 2.1‐fold (95% confidence interval [CI], 1.231–3.621), 1.9‐fold [95% CI, 1.123–3.325] and 2.1‐fold [95% CI, 1.317–3.508], respectively. The model for end‐stage liver disease (MELD) score had a c‐statistic of 0.894 (95% CI, 0.778–1.000) with a sensitivity of 67% and a specificity of 95% for poor outcomes. COX analysis showed that the MELD ≥ 18 was predictive of immunotherapy‐related ALF or death.ConclusionsPD‐(L)1 inhibitor‐related liver injury manifests primarily as a cholestatic pattern, on which corticosteroid treatment has minimal effect compared to hepatocellular and mixed patterns. MELD score ≥ 18 at the time of liver injury performed best in the prediction of ALF or death in immune checkpoint inhibitor (ICI)‐related DILI.
Post‐collaborative benefits: A meta‐analysis of the effect of collaboration on subsequent individual retrieval
Authors: Gao Yuan‐Xia , Chu Yue , Liu Xi‐Ping , Tang Wei‐Hai 
Published: July 2024

AbstractCollaboration has an essential role in memory, and how to appropriately use it to affect individual memory positively is a matter of concern. The meta‐analysis generally assessed the effect of collaboration on subsequent individual retrieval, registered on the PROSPERO platform and adhering to the PRISMA guidelines, using the Web of Science, Science Direct, CNKI and WanFang databases with post‐collaborative memory as the main subject, screened studies published up to December 31, 2023, a total of 64 studies with 101 effect sizes, including 13,398 participants from 11 countries. Heterogeneity test, sensitivity analysis, subgroup analysis and meta‐regression analysis were performed on the included studies, while publication bias was assessed. The results found that collaboration improves subsequent individual retrieval memory more than individuals, and collaboration has a moderate facilitating effect on subsequent individual retrieval. Group size, material category, category size, collaboration phase, collaboration approach, task process and test method were among the moderating variables. The study emphasizes the role of collaboration in cognition and demonstrates the post‐collaborative benefits. The conclusions are of value for developing methods to improve individual memory.
Caries trajectories from childhood to adolescence: Analysis of data from a nationwide school dental service
Authors: Tan Sharon Hui Xuan , Teo Yik‐Ying , Tan Melissa Hui Xian , Heng Wong Yim , Chen Wenjia , Gao Xiaoli 
Published: July 2024

AbstractObjectivesThe aim of the study was to assess patterns of longitudinal changes in caries status among school‐going children in Singapore.MethodsDental records for a single cohort of students who received dental examinations in six standard examination years between 2009 and 2017 were analysed (n = 24 699). Group‐based trajectory modelling with a zero‐inflated Poisson distribution was carried out to determine dental caries trajectories in the permanent dentition. Associations between sociodemographic factors and trajectory group membership were assessed using multinomial logistic regression.ResultsThe predicted population distribution across the four caries trajectory groups identified was 65.0% (‘none’), 16.8% (‘low’), 14.8% (‘medium’) and 3.4% (‘high’). The ‘none’ trajectory group had a decayed, missing and filled teeth (DMFT) score of 0 throughout the 8 years. Higher baseline DMFT counts and nonlinear increases in DMFT scores were noted for the ‘low’, ‘medium’ and ‘high’ trajectory groups. The correlation coefficient between DMFT counts in years 6 and 8 was 0.91, as compared to 0.77 between baseline and year 1. Factors associated with the ‘high’ caries trajectory include lower socio‐economic status, female gender, Chinese race (compared to the Indian race), enrolment in primary schools in the Eastern and Western regions of Singapore, and enrolment in public secondary schools.ConclusionsUnder a nationwide school dental service, four trajectory patterns of caries counts in the permanent dentition were identified over 8 years. Among students in the ‘low’, ‘medium’ and ‘high’ trajectory groups, greater caries increment was noted during the transition from primary to secondary school. The correlation between DMFT counts in successive examinations was stronger in older than younger ages.
Contact allergy to neomycin in consecutively patch tested Danish eczema patients from 2000 to 2023: A cross‐sectional study
Authors: Kursawe Larsen Christoffer , Jensen Mikkel Bak , Schwensen Jakob F. B. 
Published: July 2024

AbstractBackgroundNeomycin is an aminoglycoside antibiotic that may cause contact allergy. It was withdrawn as a medicine for human use in Denmark in October 2009 but is still found in some vaccines.ObjectivesTo identify time trends in contact allergy to neomycin in the period from 2000 to 2023.MethodsA cross‐section study of patients ≥18 years consecutively patch‐tested with neomycin sulfate (20% in pet.) at Gentofte Hospital, Denmark, during the period 2000–2023 was conducted.ResultsThe overall prevalence of contact allergy to neomycin was 1.4%. The prevalence was significantly lower in the period ‘2010–2023’ (1.2%) than in ‘2000–2009’ (1.8%) (p < 0.005). Contact allergy to neomycin was significantly positively associated with facial dermatitis and age >40 years, and significantly negatively associated with occupational dermatitis and hand dermatitis. No changes in sex, occupational dermatitis, atopic dermatitis, hand dermatitis, leg dermatitis, facial dermatitis, or age > 40/≤40 (the MOAHLFA‐index) were identified when comparing neomycin contact allergic‐patients in the two periods ‘2010–2023’ and ‘2001–2009’.ConclusionNeomycin is a rare cause of contact allergy in Denmark with a significantly lower prevalence following its withdrawal as a medicinal product for human use in Denmark in 2009.
Factors influencing diabetes treatment satisfaction in the INtegrating DEPrEssioN and Diabetes treatmENT randomized clinical trial: A multilevel model analysis
Authors: Cooper Zach , Johnson Leslie , Ali Mohammed K. , Patel Shivani A. , Poongothai Subramani , Mohan Viswanathan , Anjana R. M. , Tandon N. , Khadgawat R. , Sridhar G. R. , Aravind S. R. , Sosale B. , Sagar R. , Shankar Radha , Sundari Bhavani , Kosari Madhu , Venkat Narayan K. M. , Rao Deepa , Chwastiak Lydia 
Published: July 2024

AbstractAimsPatient satisfaction is associated with positive diabetes outcomes. However, there are no identified studies that evaluate both patient‐ and clinic‐level predictors influencing diabetes care satisfaction longitudinally.MethodsData from the INtegrating DEPrEssioN and Diabetes treatmENT trial was used to perform the analysis. We used fixed and random effects models to assess whether and how changes in patient‐level predictors (treatment assignment, depression symptom severity, systolic blood pressure, body mass index, LDL cholesterol, and haemoglobin A1C) from 0 to 24 months and clinic‐level predictors (visit frequency, visit cost, number of specialists, wait time, time spent with healthcare provider, and receiving verbal reminders) measured at 24 months influence diabetes care satisfaction from 0 to 24 months.ResultsModel 1 (patient‐level predictors) accounted for 7% of the change in diabetes satisfaction and there was a significant negative relationship between change in depressive symptoms and care satisfaction (β = −0.23, SE = 0.12, p < 0.05). Within Model 1, 2% of the variance was explained by clinic‐level predictors. Model 2 included both patient‐ and clinic‐level predictors and accounted for 18% of the change in diabetes care satisfaction. Within Model 2, 9% of the variance was attributed to clinic‐level predictors. There was also a cross‐level interaction where the change in depression had less of an impact on the change in satisfaction for those who received a verbal reminder (β = −0.11, SE = 0.21, p = 0.34) compared with those who did not receive a reminder (β = −0.62, SE = 0.08, p < 0.01).ConclusionsIncreased burden of depressive symptoms influences diabetes care satisfaction. Clinic‐level predictors also significantly influence diabetes care satisfaction and can reduce dissatisfaction in primary care, specifically, reminder calls from clinic staff.
Domain‐general cognitive control processes in bilingual switching: Evidence from midfrontal theta oscillations
Authors: Cui Ningjing , Piai Vitoria , Zheng Xiaochen Y. 
Published: July 2024

AbstractLanguage control in bilingual speakers is thought to be implicated in effectively switching between languages, inhibiting the non‐intended language, and continuously monitoring what to say and what has been said. It has been a matter of controversy concerning whether language control operates in a comparable manner to cognitive control processes in non‐linguistic domains (domain‐general) or if it is exclusive to language processing (domain‐specific). As midfrontal theta oscillations have been considered as an index of cognitive control, examining whether a midfrontal theta effect is evident in tasks requiring bilingual control could bring new insights to the ongoing debate. To this end, we reanalysed the EEG data from two previous bilingual production studies where Dutch–English bilinguals named pictures based on colour cues. Specifically, we focused on three fundamental control processes in bilingual production: switching between languages, inhibition of the nontarget language, and monitoring of speech errors. Theta power increase was observed in switch trials compared to repeat trials, with a midfrontal scalp distribution. However, no theta power difference was observed in switch trials following a shorter sequence of same‐language trials compared to a longer sequence, suggesting a missing modulation of inhibitory control. Similarly, increased midfrontal theta power was observed when participants failed to switch to the intended language compared to correct responses. Altogether, these findings tentatively support the involvement of domain‐general cognitive control mechanisms in bilingual switching.
Optimizing fraud detection in financial transactions with machine learning and imbalance mitigation
Authors: Al‐dahasi Ezaz Mohammed , Alsheikh Rama Khaled , Khan Fakhri Alam , Jeon Gwanggil 
Published: July 2024

AbstractThe rapid advancement of the Internet and digital payments has transformed the landscape of financial transactions, leading to both technological progress and an alarming rise in cybercrime. This study addresses the critical issue of financial fraud detection in the era of digital payments, focusing on enhancing operational risk frameworks to mitigate the increasing threats. The objective is to improve the predictive performance of fraud detection systems using machine learning techniques. The methodology involves a comprehensive data preprocessing and model creation process, including one‐hot encoding, feature selection, sampling, standardization, and tokenization. Six machine learning models are employed for fraud detection, and their hyperparameters are optimized. Evaluation metrics such as accuracy, precision, recall, and F1‐score are used to assess model performance. Results reveal that XGBoost and Random Forest outperform other models, achieving a balance between false positives and false negatives. The study meets the requirements for fraud detection systems, ensuring accuracy, scalability, adaptability, and explainability. This paper provides valuable insights into the efficacy of machine learning models for financial fraud detection and emphasizes the importance of striking a balance between false positives and false negatives.
Analytical assessment of low‐ and high‐cycle fatigue behavior of welded components considering the linear hardening model
Authors: Liu Shaoqing , Lei Linshen , Gu Tang , Lan Tian , Wang Chengqi , Su Yangxuan , Wang Lingjun , Liu Xiaochao 
Published: July 2024

AbstractWelded components are highly vulnerable to fatigue failures due to stress concentrations and material imperfections. This study develops an analytical framework that predicts both high‐cycle (HCF) and low‐cycle (LCF) fatigue lives of welded joints using a structural strain parameter. By employing a linear hardening model, the method effectively translates structural stress into structural strain, providing a reliable metric for assessing fatigue life, especially in LCF conditions. Validated against experimental data from 62 longitudinal gusset joints, the approach proves both reliable and practical. This simplified method facilitates easier fatigue assessments, encouraging its wider use and potential standardization in engineering, thus improving the predictability of welded structures' performance.
Lateral connectivity maintains higher freshwater mussel biodiversity
Authors: Liu Xiongjun , Sousa Ronaldo , Guo Shuhan , Wu Ruiwen , Ouyang Shan , Wu Xiaoping 
Published: July 2024

Abstract

The loss of lateral hydrological connectivity (LLHC) in freshwater ecosystems is increasingly threatening biodiversity; however, studies reporting this situation are limited, especially those assessing multi‐measure biodiversity features at large spatial scales.

Here, and using one the most threatened taxonomic groups in freshwater ecosystems, we examined the possible influence of LLHC on the species diversity, density, and biomass of mussel assemblages and the genetic diversity and structure of Nodularia douglasiae (a common and widespread native species) in the Yangtze River floodplain.

Results showed that the species diversity of freshwater mussels (α and β diversity) significantly differed between the connected and the disconnected areas, with higher α diversity and lower β diversity in the connected areas. At the same time, relative abundance, density, biomass, and genetic diversity of freshwater mussels were higher in the connected areas. High genetic differentiation and low gene flow were found among the 18 analysed N. douglasiae populations, indicating that LLHC is affecting genetic structure of this particular freshwater mussel species.

Overall, results indicated that river–lake connectivity is affecting freshwater mussel biodiversity. In addition, this study highlights that multi‐measure biodiversity features provide distinct information about biodiversity dynamics, and are essential to evaluate the effects of floodplain disconnection. We advocate that an integrative approach to floodplain management embracing species and genetic diversity is needed for effective biodiversity conservation in large river ecosystems.
Moss species and precipitation mediate experimental warming stimulation of growing season N2 fixation in subarctic tundra
Authors: Lett Signe , Christiansen Casper T. , Dorrepaal Ellen , Michelsen Anders 
Published: July 2024

AbstractClimate change in high latitude regions leads to both higher temperatures and more precipitation but their combined effects on terrestrial ecosystem processes are poorly understood. In nitrogen (N) limited and often moss‐dominated tundra and boreal ecosystems, moss‐associated N2 fixation is an important process that provides new N. We tested whether high mean annual precipitation enhanced experimental warming effects on growing season N2 fixation in three common arctic‐boreal moss species adapted to different moisture conditions and evaluated their N contribution to the landscape level. We measured in situ N2 fixation rates in Hylocomium splendens, Pleurozium schreberi and Sphagnum spp. from June to September in subarctic tundra in Sweden. We exposed mosses occurring along a natural precipitation gradient (mean annual precipitation: 571–1155 mm) to 8 years of experimental summer warming using open‐top chambers before our measurements. We modelled species‐specific seasonal N input to the ecosystem at the colony and landscape level. Higher mean annual precipitation clearly increased N2 fixation, especially during peak growing season and in feather mosses. For Sphagnum‐associated N2 fixation, high mean annual precipitation reversed a small negative warming response. By contrast, in the dry‐adapted feather moss species higher mean annual precipitation led to negative warming effects. Modelled total growing season N inputs for Sphagnum spp. colonies were two to three times that of feather mosses at an area basis. However, at the landscape level where feather mosses were more abundant, they contributed 50% more N than Sphagnum. The discrepancy between modelled estimates of species‐specific N input via N2 fixation at the moss core versus ecosystem scale, exemplify how moss cover is essential for evaluating impact of altered N2 fixation. Importantly, combined effects of warming and higher mean annual precipitation may not lead to similar responses across moss species, which could affect moss fitness and their abilities to buffer environmental changes.
Weakened connection between spring leaf‐out and autumn senescence in the Northern Hemisphere
Authors: Zhang Yichen , Hong Songbai , Peñuelas Josep , Xu Hao , Wang Kai , Zhang Yao , Lian Xu , Piao Shilong 
Published: July 2024

AbstractVegetation autumn phenology is critical in regulating the ecosystem carbon cycle and regional climate. However, the dominant drivers of autumn senescence and their temporal shifts under climate change remain poorly understood. Here, we conducted a multi‐factor analysis considering both direct climatic controls and biological carryover effects from start‐of‐season (SOS) and seasonal peak vegetation activities on the end‐of‐season (EOS) to fill these knowledge gaps. Combining satellite and ground observations across the northern hemisphere, we found that carryover effects from early‐to‐peak vegetation activities exerted greater influence on EOS than the direct climatic controls on nearly half of the vegetated land. Unexpectedly, the carryover effects from SOS on EOS have significantly weakened over recent decades, accompanied by strengthened climatic controls. Such results indicate the weakened constraint of leaf longevity on senescence due to prolonged growing season in response to climate change. These findings underscore the important role of biological carryover effects in regulating vegetation autumn senescence under climate change, which should be incorporated into the formulation and enhancement of phenology modules utilized in land surface models.