bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation, Crystal Structure, Electronic Structure, Impedance Spectroscopy, and Raman Spectroscopy of Li3SbS3 and Li3AsS3
Authors: Huber Sebastian , Preitschaft Christian , Weihrich Richard , Pfitzner Arno 
Published: September 2012

AbstractLi3SbS3 was synthesized by solid‐state reaction of stoichiometric amounts of Li2S and Sb2S3 in the ratio 3:1. The product is air and moisture sensitive. The crystal structure was determined from single crystals at room temperature. Pale grey Li3SbS3 crystallizes in the orthorhombic space group Pna21 (no. 33) with a = 7.9671(5) Å, b = 6.7883(5) Å, c = 10.0912(8) Å, V = 545.76(7) Å3, and Z = 4 (data at 20 °C). Antimony and sulfur atoms build isolated, trigonal pyramidal [SbS3]3– units, which are stacked along [100]. These [SbS3]3– units are connected by [LiSx]‐polyhedra. The lithium ions have either a distorted tetrahedral coordination by sulfur in the case of Li2 and Li3 or a distorted square pyramidal environment in the case of Li1. The crystal structure is isotypic with Li3AsS3, which was obtained by reaction of stoichiometric amounts of lithium, arsenic, and sulfur in the ratio 3:1:3 in an excess of LiI. LiI serves only as a flux and is not incorporated in the crystal structure. Li3AsS3 crystallizes as colorless rods, space group Pna21 (no. 33) with a = 8.090(1) Å, b = 6.658(1) Å, c = 9.868(1) Å, V = 531.5(1) Å3, and Z = 4 (data at 20 °C). Both compounds are confirmed as semiconductors with bandgaps close to 3 eV from DFT‐calculations with GGA and hybrid functionals. Impedance spectroscopic measurements of Li3SbS3 show a specific conductivity of σ = 1.6 × 10–9 Ω–1 cm–1 at 323 K and of σ = 5.4 × 10–5 Ω–1 cm–1 at 573 K. The activation energy is EA = 0.72 eV. Raman spectra of Li3SbS3 are dominated by the stretching modes of the [SbS3]3– units at 333, 317, and 301 cm–1 at room temperature.
Adapting School‐Based Substance Use Prevention Curriculum Through Cultural Grounding: A Review and Exemplar of Adaptation Processes for Rural Schools
Authors: Colby Margaret , Hecht Michael L. , Miller-Day Michelle , Krieger Janice L. , Syvertsen Amy K. , Graham John W. , Pettigrew Jonathan 
Published: September 2012

AbstractA central challenge facing twenty‐first century community‐based researchers and prevention scientists is curriculum adaptation processes. While early prevention efforts sought to develop effective programs, taking programs to scale implies that they will be adapted, especially as programs are implemented with populations other than those with whom they were developed or tested. The principle of cultural grounding, which argues that health message adaptation should be informed by knowledge of the target population and by cultural insiders, provides a theoretical rational for cultural regrounding and presents an illustrative case of methods used to reground the keepin’ it REAL substance use prevention curriculum for a rural adolescent population. We argue that adaptation processes like those presented should be incorporated into the design and dissemination of prevention interventions.
Therapie mitochondrialer Erkrankungen
Authors: Kornblum C. 
Published: September 2012

Zusammenfassung
Im Verständnis pathogenetischer Grundlagen mitochondrialer Erkrankungen sind bedeutende Fortschritte zu verzeichnen. Die Therapie ist dagegen noch überwiegend symptomatisch, kurative Behandlungen stehen nicht zur Verfügung. Allerdings befinden sich zahlreiche Substanzen, diätetische Modifikationen und Interventionen in Untersuchung, die verschiedene Ziele wie eine antioxidative Wirkung, Supplementation von Metaboliten oder Elimination toxischer Stoffwechselprodukte verfolgen. Aktuell gibt es keine klare Evidenz für eine gesicherte Wirksamkeit dieser vielfältigen Therapieansätze. Ausnahmen bilden möglicherweise der Ausgleich von metabolischen Mangelzuständen oder die Elimination toxischer Metabolite, zudem liegen Hinweise auf einen Nutzen von Idebenon bei hereditärer Leber-Optikusneuropathie (LHON) vor. Die Datenlage hinsichtlich methodisch hochwertiger Studien ist aber noch limitiert, kontrollierte Studien an homogenen Patientenkollektiven sind zukünftig zu fordern. Erfolgversprechende gentherapeutische Ansätze werden verfolgt, sind aber noch nicht praxisrelevant.
Parents as a resource: Communication quality affects the relationship between adolescents' internet use and loneliness
Authors: Appel Markus , Holtz Peter , Stiglbauer Barbara , Batinic Bernad 
Published: September 2012

ABSTRACTThe authors examined the influence of parent–adolescent communication quality, as perceived by the adolescents, on the link between adolescents' Internet use and loneliness, controlling for perceived family support in general terms. Adolescents (N = 216, Mage = 15.80 years) provided data on Internet use, loneliness, Internet‐related parent–adolescent communication, and perceived family support. Moderated regression analyses showed that Internet‐related communication quality determined whether more extensive Internet use was associated with more loneliness. This moderation effect remained significant when perceived family support in general terms was controlled for. Gender and age of the participants did not influence the findings. Implications for successful Internet‐related parenting strategies are discussed.
On the steady-state fully resonant progressive waves in water of finite depth
Authors: Xu Dali , Lin Zhiliang , Liao Shijun , Stiassnie Michael 
Published: September 2012

AbstractThe steady-state fully resonant wave system, consisting of two progressive primary waves in finite water depth and all components due to nonlinear interaction, is investigated in detail by means of analytically solving the fully nonlinear wave equations as a nonlinear boundary-value problem. It is found that multiple steady-state fully resonant waves exist in some cases which have no exchange of wave energy at all, so that the energy spectrum is time-independent. Further, the steady-state resonant wave component may contain only a small proportion of the wave energy. However, even in these cases, there usually exist time-dependent periodic exchanges of wave energy around the time-independent energy spectrum corresponding to such a steady-state fully resonant wave, since it is hard to be exactly in such a balanced state in practice. This view serves to deepen and enrich our understanding of the resonance of gravity waves.
Gender, Uyghur Identity, and the Story of Nuzugum
Authors: Abramson Kara 
Published: September 2012

This article examines the relationship between gender and Uyghur identity through the story of Nuzugum, the allegory of a Kashgar woman who kills an enemy outsider she is forced to marry rather than yield her chastity and bear his children. Tracing the story from its nineteenth-century roots to literary, artistic, and political incarnations in recent decades, the article argues that the story's prominence in the canon of Uyghur literature and its eponymous protagonist's place among Uyghur national heroes highlights the integral but overlooked role of gender in the construction of modern Uyghur identity. The resiliency of the story's gendered themes also underscores gender's importance in contemporary Uyghur political advocacy, especially advocacy about the transfer of Uyghur women to factories in China's coastal cities, an issue connected to the July 2009 protests and riots in the Xinjiang Uyghur Autonomous Region.
Sample size estimation to substantiate freedom from disease for clustered binary data with a specific risk profile
Authors: KOSTOULAS P. , NIELSEN S. S. , BROWNE W. J. , LEONTIDES L. 
Published: September 2012

SUMMARYDisease cases are often clustered within herds or generally groups that share common characteristics. Sample size formulae must adjust for the within-cluster correlation of the primary sampling units. Traditionally, the intra-cluster correlation coefficient (ICC), which is an average measure of the data heterogeneity, has been used to modify formulae for individual sample size estimation. However, subgroups of animals sharing common characteristics, may exhibit excessively less or more heterogeneity. Hence, sample size estimates based on the ICC may not achieve the desired precision and power when applied to these groups. We propose the use of the variance partition coefficient (VPC), which measures the clustering of infection/disease for individuals with a common risk profile. Sample size estimates are obtained separately for those groups that exhibit markedly different heterogeneity, thus, optimizing resource allocation. A VPC-based predictive simulation method for sample size estimation to substantiate freedom from disease is presented. To illustrate the benefits of the proposed approach we give two examples with the analysis of data from a risk factor study on Mycobacterium avium subsp. paratuberculosis infection, in Danish dairy cattle and a study on critical control points for Salmonella cross-contamination of pork, in Greek slaughterhouses.
Colistinvs. the combination of colistin and rifampicin for the treatment of carbapenem-resistantAcinetobacter baumanniiventilator-associated pneumonia
Authors: AYDEMIR H. , AKDUMAN D. , PISKIN N. , COMERT F. , HORUZ E. , TERZI A. , KOKTURK F. , ORNEK T. , CELEBI G. 
Published: September 2012

SUMMARYThe aim of this study was to compare the responses of colistin treatment alonevs. a combination of colistin and rifampicin in the treatment of ventilator-associated pneumonia (VAP) caused by a carbapenem-resistantA. baumanniistrain. Forty-three patients were randomly assigned to one of two treatment groups. Although clinical (P = 0·654), laboratory (P = 0·645), radiological (P = 0·290) and microbiological (P = 0·597) response rates were better in the combination group, these differences were not significant. However, time to microbiological clearance (3·1 ± 0·5 days,P = 0·029) was significantly shorter in the combination group. The VAP-related mortality rates were 63·6% (14/22) and 38·1% (8/21) for the colistin and the combination groups (P = 0·171), respectively. Our results suggest that the combination of colistin with rifampicin may improve clinical and microbiological outcomes of VAP patients infected withA. baumannii.
Enzyme-linked immunosorbent assay to diagnose human leptospirosis: a meta-analysis of the published literature
Authors: SIGNORINI M. L. , LOTTERSBERGER J. , TARABLA H. D. , VANASCO N. B. 
Published: September 2012

SUMMARYWe report an evaluation of the accuracy of ELISA for the detection ofLeptospira-specific antibodies in humans. Eighty-eight studies published in 35 articles met all inclusion criteria and were submitted to meta-analysis. Pooled sensitivity and specificity were 0·779 (95% CI 0·770–0·789) and 0·913 (95% CI 0·908–0·917), respectively, and the area under the curve was 0·964. Heterogeneity across studies was statistically significant, but none of the sources of heterogeneity (disease stage, antigen used, antibody detected) could fully explain this finding. Although the convalescent stage of disease was significantly associated with higher diagnostic accuracy, IgM ELISA was the best choice, regardless of the stage of disease. Negative ELISAs (IgG or IgM) applied in the acute phase do not rule out leptospirosis due to the possibility of false-negative results. In this case it is advisable to request a second blood sample or to apply a direct method for leptospiral DNA.
Prevalence and factors associated with overweight and obesity in French primary-school children
Authors: Thibault Hélène , Carriere Caroline , Langevin Coralie , Kossi Déti Edouard , Barberger-Gateau Pascale , Maurice Sylvie 
Published: September 2012

AbstractObjectiveTo determine the prevalence of, and identify associated factors with, overweight and obesity in two samples of French children.DesignWe conducted two cross-sectional studies among two samples of children. Weight status, eating behaviour, sedentary activity, physical activity and parents’ socio-economic status (SES) were collected using questionnaires filled by doctors during school health check-ups. Overweight and obesity were defined according to the age- and sex-specific BMI cut-off points of the International Obesity Taskforce. Multivariate analysis (logistic regression) was used to identify independent factors associated with overweight including obesity and obesity alone.SettingAquitaine region (south-west France).SubjectsAnalyses were conducted among children aged 5–7 years (n 4048) and 7–11 years (n 3619).ResultsOverweight prevalence was 9·5 % including 2·2 % of obesity in 5–7-year-old children and 15·6 % including 2·9 % of obesity in 7–11-year-old children. In both samples, overweight and obesity prevalence were higher in children whose parents had low or medium SES (P < 0·05). Factors associated significantly (P < 0·05) and independently with higher overweight or obesity prevalence were female gender, low or medium parental SES, never or sometimes having breakfast, never eating at the school canteen, never having a morning snack, never or sometimes having a light afternoon meal and having high sedentary activity.ConclusionsOur data confirm that low SES, absence of breakfast and high sedentary activity are associated with a higher risk of being overweight or obese, but also highlight original potential protective factors such as eating at the canteen and high meal frequency.
Fossils and astrobiology: new protocols for cell evolution in deep time
Authors: Brasier Martin D. , Wacey David 
Published: September 2012

AbstractThe study of life remote in space has strong parallels with the study of life remote in time. Both are dependent on decoding those historic phenomena called ‘fossils’, here taken to include biogenic traces of activity and waste products. There is the shared problem of data restoration from incomplete data sets; the importance of contextual analysis of potentially viable habitats; the centrality of cell theory; the need to reject the null hypothesis of an abiogenic origin for candidate cells via morphospace analysis; the need to demonstrate biology-like behaviour (e.g., association with biofilm-like structures; tendency to form clusters and ‘mats’; and a preference for certain substrates), and of metabolism-like behaviour (e.g., within the candidate cell wall; within surrounding ‘waste products’; evidence for syntrophy and metabolic cycles; and evidence for metabolic tiers). We combine these ideas into a robust protocol for demonstrating ancient or extra-terrestrial life, drawing examples from Earth's early geological record, in particular from the earliest known freshwater communities of the 1.0 Ga Torridonian of Scotland, from the 1.9 Ga Gunflint Chert of Canada, from the 3.4 Ga Strelley Pool sandstone of Australia, and from the 3.46 Ga Apex Chert also of Australia.
Registration of Blood Exposure Accidents in the Netherlands by a Nationally Operating Call Center
Authors: Schneeberger Peter M. , Meiberg Annemarie E. , Warmelts Janet , Leenders Sander C. A. P. , van Wijk Paul T. L. 
Published: September 2012

Objective.Healthcare providers and other employees, especially those who do not work in a hospital, may not easily find help after the occurrence of a blood exposure accident. In 2006, a national call center was established in the Netherlands to fill this gap.Methods.All occupational blood exposure accidents reported to the 24-hours-per-day, 7-days-per-week call center from 2007, 2008, and 2009 were analyzed retrospectively for incidence rates, risk assessment, handling, and preventive measures taken.Results.A total of 2,927 accidents were reported. The highest incidence rates were reported for private clinics and hospitals (68.5 and 54.3 accidents per 1,000 person-years, respectively). Dental practices started reporting incidents frequently after the arrangement of a collective financial agreement with the call center. Employees of ambulance services, midwife practices, and private clinics reported mostly high-risk accidents, whereas penitentiaries frequently reported low-risk accidents. Employees in mental healthcare facilities, private clinics, and midwife practices reported accidents relatively late. The extent of hepatitis B vaccination in mental healthcare facilities, penitentiaries, occupational health services, and cleaning services was low (<70%).Conclusions.The national call center successfully organized the national registration and handling of blood exposure accidents. The risk of blood exposure accidents could be estimated on the basis of this information for several occupational branches. Targeted preventive measures for healthcare providers and other employees at risk can next be developed.Infect Control Hosp Epidemiol 2012;33(10):1017-1023
Device-Associated Infection Rates, Device Utilization, and Antimicrobial Resistance in Long-Term Acute Care Hospitals Reporting to the National Healthcare Safely Network, 2010
Authors: Chitnis Amit S. , Edwards Jonathan R. , Ricks Phillip M. , Sievert Dawn M. , Fridkin Scott K. , Gould Carolyn V. 
Published: September 2012

Objective.To evaluate national data on healthcare-associated infections (HAIs), device utilization, and antimicrobial resistance in long-term acute care hospitals (LTACHs).Design and Setting.Comparison of data from LTACHs and from medical and medical-surgical intensive care units (ICUs) in short-stay acute care hospitals reporting to the National Healthcare Safety Network (NHSN) during 2010.Methods.Rates of central line–associated bloodstream infections (CLABSIs), catheter-associated urinary tract infections (CAUTIs), and ventilator-associated pneumonia (VAP) as well as device utilization ratios were calculated. For each HAI, pathogen profiles and antimicrobial resistance prevalence were evaluated. Comparisons were made using Poisson regression and the Mood median and x2 tests.Results.In 2010, 104 LTACHs reported CLABSIs and 57 reported CAUTIs and VAP to the NHSN. Median CLABSI rates in LTACHs (1.25 events per 1,000 device-days reported; range, 0.0-5.96) were comparable to rates in major teaching ICUs and were higher than those in other ICUs. CAUTI rates in LTACHs (median, 2.61; range, 0.0-9.92) were higher and VAP rates (median, 0.0; range, 0.0-3.29) were generally lower than those in ICUs. Central line utilization in LTACHs was higher than that in ICUs, whereas urinary catheter and ventilator utilization was lower. Methicillin resistance among Staphylococcus aureus CLABSIs (83%) and vancomycin resistance among Enterococcus faecalis CAUTIs (44%) were higher in LTACHs than in ICUs. Multidrug resistance among Pseudomonas aeruginosa CAUTIs (25%) was higher in LTACHs than in most ICUs.Conclusions.CLABSIs and CAUTIs associated with multidrug-resistant organisms present a challenge in LTACHs. Continued HAI surveillance with pathogen-level data can guide prevention efforts in LTACHs.Infect Control Hosp Epidemiol 2012;33(10):993-1000
Evolution of gene neighborhoods within reconciled phylogenies
Authors: Bérard Sèverine , Gallien Coralie , Boussau Bastien , Szöllősi Gergely J. , Daubin Vincent , Tannier Eric 
Published: September 2012

Abstract
Motivation: Most models of genome evolution integrating gene duplications, losses and chromosomal rearrangements are computationally intract able, even when comparing only two genomes. This prevents large-scale studies that consider different types of genome structural variations.
Results: We define an ‘adjacency phylogenetic tree’ that describes the evolution of an adjacency, a neighborhood relation between two genes, by speciation, duplication or loss of one or both genes, and rearrangement. We describe an algorithm that, given a species tree and a set of gene trees where the leaves are connected by adjacencies, computes an adjacency forest that minimizes the number of gains and breakages of adjacencies (caused by rearrangements) and runs in polynomial time. We use this algorithm to reconstruct contiguous regions of mammalian and plant ancestral genomes in a few minutes for a dozen species and several thousand genes. We show that this method yields reduced conflict between ancestral adjacencies. We detect duplications involving several genes and compare the different modes of evolution between phyla and among lineages.
Availability: C++ implementation using BIO++ package, available upon request to Sèverine Bérard.
Contact: Severine.Berard@cirad.fr or Eric.Tannier@inria.fr
Supplementary information: Supplementary material is available at Bioinformatics online.
An exome sequencing pipeline for identifying and genotyping common CNVs associated with disease with application to psoriasis
Authors: Coin Lachlan J.M. , Cao Dandan , Ren Jingjing , Zuo Xianbo , Sun Liangdan , Yang Sen , Zhang Xuejun , Cui Yong , Li Yingrui , Jin Xin , Wang Jun 
Published: September 2012

Abstract
Motivation: Despite the prevalence of copy number variation (CNV) in the human genome, only a handful of confirmed associations have been reported between common CNVs and complex disease. This may be partially attributed to the difficulty in accurately genotyping CNVs in large cohorts using array-based technologies. Exome sequencing is now widely being applied to case–control cohorts and presents an exciting opportunity to look for common CNVs associated with disease.
Results: We developed ExoCNVTest: an exome sequencing analysis pipeline to identify disease-associated CNVs and to generate absolute copy number genotypes at putatively associated loci. Our method re-discovered the LCE3B_LCE3C CNV association with psoriasis (P-value = 5 × 10e−6) while controlling inflation of test statistics (λ &lt; 1). ExoCNVTest-derived absolute CNV genotypes were 97.4% concordant with PCR-derived genotypes at this locus.
Availability and implementation: ExoCNVTest has been implemented in Java and R and is freely available from www1.imperial.ac.uk/medicine/people/l.coin/.
Contact: wangj@genomics.org.cn or Lachlan.J.M.Coin@genomics.org.cn
Relating drug–protein interaction network with drug side effects
Authors: Mizutani Sayaka , Pauwels Edouard , Stoven Véronique , Goto Susumu , Yamanishi Yoshihiro 
Published: September 2012

AbstractMotivation: Identifying the emergence and underlying mechanisms of drug side effects is a challenging task in the drug development process. This underscores the importance of system–wide approaches for linking different scales of drug actions; namely drug-protein interactions (molecular scale) and side effects (phenotypic scale) toward side effect prediction for uncharacterized drugs.Results: We performed a large-scale analysis to extract correlated sets of targeted proteins and side effects, based on the co-occurrence of drugs in protein-binding profiles and side effect profiles, using sparse canonical correlation analysis. The analysis of 658 drugs with the two profiles for 1368 proteins and 1339 side effects led to the extraction of 80 correlated sets. Enrichment analyses using KEGG and Gene Ontology showed that most of the correlated sets were significantly enriched with proteins that are involved in the same biological pathways, even if their molecular functions are different. This allowed for a biologically relevant interpretation regarding the relationship between drug–targeted proteins and side effects. The extracted side effects can be regarded as possible phenotypic outcomes by drugs targeting the proteins that appear in the same correlated set. The proposed method is expected to be useful for predicting potential side effects of new drug candidate compounds based on their protein-binding profiles.Supplementary information: Datasets and all results are available at http://web.kuicr.kyoto-u.ac.jp/supp/smizutan/target-effect/.Availability: Software is available at the above supplementary website.Contact: yamanishi@bioreg.kyushu-u.ac.jp, or goto@kuicr.kyoto-u.ac.jp