bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foam Mobility Control During WAG Injection in a Difficult Reservoir With High Temperature and High Acid Gas
Authors: Mohd Shafian S. R. , Kamarul Bahrim R.. , Foo Y.. , Abdul Manap A.. , Tewari R. D. 
Published: August 2015

Abstract
One of the major challenges envisaged in the application of WAG in multilayered reservoir with large thickness is poor conformance of injectants. Critical premises in the success of any enhanced oil recovery flooding operation is that mobile oil volume should be increased and this increased volume is contacted by driving fluids to enable it to be produced from the producers. This oil volume should not be by-passed by the EOR injectant fluid. Another important aspect is that driving fluids and fluid front of mobilized oil needs to flow more or less equally throughout the reservoir. This happens when reservoir conformance is well addressed. Therefore, controlling the flood front in WAG injection is a major challenge in the success of immiscible WAG injection.
This paper presents laboratory research, lab and pilot design modeling study for developing the suitability of foam for a challenging reservoir. Foam was generated by simultaneous injection of CO2 rich injection gas with selected surfactant formulation initially saturated with surfactant. Effect of series of injection rates were investigated as main parameters for foam propagation and stability under field condition. It was observed that mobility reduction factor (MRF) increases with increasing flow rates and stabilized when the flow rates were decreased.
The effects of multiple injections at fixed flow rates and from low to high rates through Surfactant Alternating Gas (SAG) were compared. SAG at low rates not adequate in generating strong foam thus produced very low MRF. SAG at multiple small slugs from low to high rates generated high MRF caused by frequent contact and mixing between surfactant and gas. Co injection and multiple injection through SAG indicated moderate MRF are obtained at high flow rates as in the near wellbore area and high MRF ensuring good mobility control and sweep efficiency when foam propagates within the reservoir.
Estimation of Production Rates by Use of Transient Well-Flow Modeling and the Auxiliary Particle Filter: Full-Scale Applications
Authors: Lorentzen R. J. , Stordal A. S. , Luo X.. , Nævdal G.. 
Published: August 2015

Summary
In the current work, we demonstrate the use of a detailed transient multiphase well-flow model and the auxiliary sequential-importance resampling filter, for better representation of flow rates in petroleum wellbores (influx and/or outflux). The fundamentals of the methodology have been presented by the authors in a previous work, and the purpose of this paper is full-scale case studies. Performance, robustness, and flexibility are demonstrated with data sets from two different wells.
The first case is an application to an inclined gas producer with two inflow reservoir zones. Observations consist of pressure and temperature at two locations in the well. Next, we present an application to an inclined water injector with nine outflow zones. Observations consist of data from a distributed temperature sensor (DTS) and one pressure observation at the end of the DTS rod.
Estimate of zonal flow rates, including error bounds, lead to better well control and reservoir management, which again are important for improved recovery of oil from existing petroleum fields. The results presented in this paper clearly demonstrate the feasibility of automatic identification of reservoir flow-rate distribution from wellbore measurements.
Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing
Authors: Mpakali Anastasia , Saridakis Emmanuel , Harlos Karl , Zhao Yuguang , Papakyriakou Athanasios , Kokkala Paraskevi , Georgiadis Dimitris , Stratikos Efstratios 
Published: August 2015

Abstract
Aminopeptidases that generate antigenic peptides influence immunodominance and adaptive cytotoxic immune responses. The mechanisms that allow these enzymes to efficiently process a vast number of different long peptide substrates are poorly understood. In this work, we report the structure of insulin-regulated aminopeptidase, an enzyme that prepares antigenic epitopes for cross-presentation in dendritic cells, in complex with an antigenic peptide precursor analog. Insulin-regulated aminopeptidase is found in a semiclosed conformation with an extended internal cavity with limited access to the solvent. The N-terminal moiety of the peptide is located at the active site, positioned optimally for catalysis, whereas the C-terminal moiety of the peptide is stabilized along the extended internal cavity lodged between domains II and IV. Hydrophobic interactions and shape complementarity enhance peptide affinity beyond the catalytic site and support a limited selectivity model for antigenic peptide selection that may underlie the generation of complex immunopeptidomes.
Explaining, Cultural, Educational and Social Needs of Faculty Members of Farhangiyan University
Authors: Basiry Batool , Nasr Ahmadreza , Mirshahjafari Seyed Ebrahim , Mehrmohammadi Mahmood 
Published: August 2015

<p>The present study is an applied research project and uses a descriptive-analytical survey design. It follows both qualitative and quantitative data collection procedures. The statistical population of the qualitative section consists of 19 Iranian education experts who are selected via targeted random sampling. And the statistical population of the quantitative section consists of all full-time instructors and faculty members of Farhangian University in six provinces of Iran (n=181), of whom 150 are selected via random sampling.<strong> </strong>Data are collected through semi-structured interviews and researcher-made questionnaires. To determine the validity of interviews and questionnaires, we have used confirmatory factor analysis for verifying construct validity and Cronbach’s alpha for estimating questionnaire reliability. Qualitative findings are analyzed based on the spiral of analysis and quantitative data are processed through descriptive and inferential statistics. According to the results of the qualitative section, the most important educational needs of Farhangian University’s faculty members fir into two areas: 1. Religious needs with an emphasis on Islamic education, and 2. ethical, cultural and social needs comprising four domains: 2.1 cultural, 2.2 social, 2.3 ethical, and 2.4 political. The results of the quantitative section also indicate that the educational needs of Farhangian University’s faculty members are higher than average in both areas. The most important need of Farhangian University’s faculty members in the cultural domain is related to the subscale “being aware of the role of university professors in relation to preserving, transferring, reforming, and recreating culture” while their most important need in the theological domain is related to “the ability to use the educational principles and implications of the Quran and Nahjolbalaghe” (Imam Ali’s book of ethical teachings)</p>
Evaluation of 3M™ Molecular Detection Assay (MDA) Listeria monocytogenes for the Detection of Listeria monocytogenes in Selected Foods and Environmental Surfaces: Collaborative Study, First Action 2014.07
Authors: Bird Patrick , Flannery Jonathan , Crowley Erin , Agin James , Goins David , Monteroso Lisa , Benesh DeAnn ,   Collaborators:, Bastin B , Blumfield J , Brahmanda B , Brandt A , Brooks R , Brooks R , Cerda L , Chavarria C , Chen Y , Cuthbert N , Dermer R , Fatemi P , Hankins A , Hardrath L , Kupski B , Laasri A , Lopez C , Mailloux B , Morris A , Picket J , Powers K , Schoeni J , Shipley N , Spencer S , Sweet A , Thielen A , Thompson L , Williams J , Wood D 
Published: August 2015

Abstract
The 3M™ Molecular Detection Assay (MDA) Listeria monocytogenes combines isothermal amplification and bioluminescence to detect Listeria monocytogenes with high specificity and efficiency in select foods and environmental samples. The 3M MDA Listeria monocytogenes method was evaluated using an unpaired study design in a multilaboratory collaborative study to the U.S. Department of Agriculture, Food Safety and Inspection Service Microbiology Laboratory Guidebook 8.09 (2011) Isolation and Identification of Listeria monocytogenes from Red Meat, Poultry, and Egg Products and Environmental Samples for deli turkey, and the AOAC Official Method of AnalysisSM 993.12 Listeria monocytogenes in Milk and Dairy Products for full-fat (4% milk fat) cottage cheese following the current AOAC guidelines. A total of 16 laboratories located in the continental United States and Canada participated in this collaborative study. For deli turkey, 125 g test portions were evaluated using heat-stressed cells by each method. For full-fat cottage cheese, 25 g test portions were evaluated using nonheat-stressed cells. Each matrix had three inoculation levels: an uninoculated control level (0 CFU/test portion), and two levels artificially contaminated with L. monocytogenes, a low inoculum level (0.2–2 CFU/test portion) and a high inoculum level (2–5 CFU/test portion). In total, 1584 unpaired replicate samples were analyzed. Statistical analysis was conducted according to the probability of detection (POD) model. Results obtained for the low inoculum level full-fat cottage cheese test portions produced a difference in cross-laboratory POD (dLPOD) value of –0.08 with a 95% confidence interval (CI) of (–0.20, 0.05). For the low-level deli turkey test portions, a dLPOD value of –0.02 with a 95% CI of (–0.14, 0.11) was obtained.
Oxygen‐responsive genetic circuits constructed in Synechocystis sp. PCC 6803
Authors: Immethun Cheryl M. , Ng Kenneth M. , DeLorenzo Drew M. , Waldron‐Feinstein Ben , Lee Ying‐Chiang , Moon Tae Seok 
Published: August 2015

ABSTRACTAs photoautotrophic prokaryotes, cyanobacteria are promising platforms for producing value‐added bioproducts. However, few regulatory genetic parts and devices (e.g., inducible promoters and regulatory circuits) have been developed for these potential hosts. Furthermore, the devices that have been created respond only to a single input. To address these issues, we developed an inducible genetic circuit that generates heterologous proteins in response to oxygen, an environmental signal. To test its performance and utility in Synechocystis sp. PCC 6803, a model cyanobacterial strain, we connected this circuit to either heterologous nifHDK genes, which encode oxygen‐sensitive nitrogenase's structural proteins, or a fluorescent protein gene. The circuit was transcriptionally activated to generate nifHDK transcripts or fluorescent output only in low oxygen conditions. We expanded the oxygen‐responsive circuit into a more complex circuit by building a two‐input AND gate, which allows Synechocystis to specifically control expression of the fluorescent reporter in response to two signals, low oxygen and high anhydrotetracycline. To our knowledge, the AND gate is the first complex logic circuit built in a cyanobacterial strain. This work expands the synthetic biology tools available for complex gene expression in cyanobacteria, increasing their potential as biotechnology platforms. Biotechnol. Bioeng. 2016;113: 433–442. © 2015 Wiley Periodicals, Inc.
Molecular Recognition and Visual Detection of G‐Quadruplexes by a Dicarbocyanine Dye
Authors: Karg Beatrice , Funke Andrea , Ficht Anna , Sievers‐Engler Adrian , Lämmerhofer Michael , Weisz Klaus 
Published: August 2015

AbstractThe interactions of a dicarbocyanine dye 3,3′‐diethylthiadicarbocyanine, DiSC2(5), with DNA G‐quadruplexes were studied by means of a combination of various spectroscopic techniques. Aggregation of excess dye as a result of its positive charge is promoted by the presence of the polyanionic quadruplex structure. Specific high‐affinity binding to the parallel quadruplex of the MYC promoter sequence involves stacking of DiSC2(5) on the external G‐tetrads; the 5′‐terminal tetrad is the favored binding site. Significant energy transfer between DNA and the dye in the UV spectral region is observed upon DiSC2(5) binding. The transfer efficiency strongly depends on the DNA secondary structure as well as on the G‐quadruplex topology. These photophysical features enable the selective detection of DNA quadruplexes through sensitized DiSC2(5) fluorescence in the visible region.
Ethyl‐Zinc(II)‐Cation Equivalents: Synthesis and Hydroamination Catalysis
Authors: Petersen T. O. , Tausch E. , Schaefer J. , Scherer H. , Roesky P. W. , Krossing I. 
Published: August 2015

AbstractIon‐like ethylzinc(II) compounds with weakly coordinating aluminates [Al(ORF)4]− and [(RFO)3Al‐F‐Al(ORF)3]− (RF=C(CF3)3) were synthesized in a one‐pot reaction and fully characterized by single‐crystal X‐ray diffraction, NMR and vibrational spectroscopy, and by quantum chemical calculations. The catalytic activity of ion‐like Et‐Zn[Al(ORF)4] in intermolecular hydroamination and in the unusual double hydroamination of anilines and alkynes was investigated. Favorable performance was also found in comparison to the Et2Zn/ [PhNMe2H]+[B(C6F5)4]− system generated in situ at lower catalyst loadings of 2.5 mol %.
Disparities in early death and survival in children, adolescents, and young adults with acute promyelocytic leukemia in California
Authors: Abrahão Renata , Ribeiro Raul C. , Medeiros Bruno C. , Keogh Ruth H. , Keegan Theresa H.M. 
Published: August 2015

BACKGROUNDFindings from clinical trials and population‐based studies have differed with regard to whether mortality within 30 days of diagnosis (early death) of acute promyelocytic leukemia (APL) has decreased in the era of all‐trans retinoic acid and anthracycline‐based chemotherapy.METHODSUsing data from the California Cancer Registry, the authors investigated 7‐day and 30‐day mortality and survival in 772 patients who were aged birth to 39 years when they were diagnosed with APL during 1988 to 2011. Logistic regression and Cox proportional models were used to examine the association of early death and survival, respectively, with sociodemographic and clinical factors.RESULTSThe overall 30‐day mortality decreased significantly over time, from 26% (1988‐1995) to 14% (2004‐2011) (P =.004). On multivariable analysis, the odds of 30‐day mortality were 3 times as high during 1988 through 1995 than 2004 through 2011 (P =.001). However, 7‐day mortality did not improve over time (P =.229). When patients who died within 7 days of diagnosis were excluded, the 30‐day mortality during 1996 to 2011 was 3% to 8%, which is similar to levels reported in clinical trials. Higher early death and lower survival were associated with a lack of health insurance (1996‐2011) (early death odds ratio, 2.67; P =.031) and Hispanic race/ethnicity (early death odds ratio, 2.13; P =.014). Early death was not found to be associated with age, sex, socioeconomic status, or hospital type. Black patients also experienced worse survival.CONCLUSIONSThe findings of the current study revealed a decreased 30‐day mortality during the all‐trans retinoic acid era, but 7‐day mortality remained high. Efforts to achieve equal outcomes in young patients with APL should focus on improving access to effective treatment, mainly among uninsured patients and those of Hispanic and black race/ethnicity. Cancer 2015;121:3990–3997. © 2015 American Cancer Society.
Neural crest specification by Prohibitin1 depends on transcriptional regulation of prl3 and vangl1
Authors: Deichmann Christina , Link Martina , Seyfang Melanie , Knotz Viktoria , Gradl Dietmar , Wedlich Doris 
Published: August 2015

SummaryA complex network of transcription factors regulates specification of neural crest cells at early neurula stage by stabilizing neural crest identity and activating neural crest effector genes so that distinct subpopulations evolve. In this network, c‐myc acts on top of the gene hierarchy controlling snail2, AP2 and prohibitin1 (phb1) expression. While snail2 and AP2 are well studied neural crest specifier genes little is known about the role of phb1 in this process. To identify phb1 regulated genes we analyzed the transcriptome of neural crest explants of phb1 morphant Xenopus embryos. Among 147 phb1 regulated genes we identified the membrane‐associated protein‐tyrosine phosphatase PRP4A3 (prl3) and the atypical cadherin and Wnt‐PCP component van gogh like1 (vangl1). Gain of function, loss of function and epistasis experiments allowed us to allocate both genes in the neural crest specification network between phb1 and twist. Interestingly, both, vangl1 and prl3 regulate only a small subset of neural crest marker genes. The identification of two membrane‐associated proteins as novel neural crest specifiers indicates that in addition to gene regulation by combinatory effects of transcription factors also post‐translational modifications (prl3) and cell–cell adhesion and/or regulation of cell‐polarity (vangl1) specify the identity of neural crest cell populations. genesis 53:627–639, 2015. © 2015 Wiley Periodicals, Inc.
What to Get and What to Give Up: How Different Decision Tasks and Product Types Affect the Persuasiveness of Promotion‐ versus Prevention‐Focused Messages
Authors: Ghosh Chowdhury Tilottama , Micu Camelia , Ratneshwar S. , Kim Eunjin (Anna) 
Published: August 2015

ABSTRACTPrior research has distinguished between ad message frames that are promotion‐focused (i.e., eager‐sounding and achievement‐oriented) and those that are prevention‐focused (i.e., vigilance‐hued and safety‐themed). In three studies, the authors investigate the relative persuasiveness of promotion‐ versus prevention‐focused messages in the context of different decision tasks (i.e., acquisition vs. forfeiture) and different types of featured products/attributes (i.e., hedonic vs. utilitarian). Studies 1 and 2 focus on message structures conducive to imagery‐based processing. The results show that promotion‐focused messages are relatively more persuasive than prevention‐focused messages in acquisition tasks than in forfeiture tasks in the case of hedonic products (and products with salient hedonic attributes). Relative persuasiveness of the two message frames is not affected by decision task in the case of utilitarian products (or products with salient utilitarian attributes). Study 3 uses message structures suited for analytical processing. In this study, interestingly, the relative persuasiveness of prevention‐focused (vs. promotion‐focused) messages is greater in forfeiture tasks than in acquisition tasks in the case of utilitarian products. Relative persuasiveness of the two message frames is not affected by decision task in the case of hedonic products. Theoretical and managerial implications of the findings are discussed.
Using a Novel CFD Model to Assess the Effect of Mixing Parameters on Emulsion Polymerization
Authors: Fathi Roudsari Shideh , Dhib Ramdhane , Ein‐Mozaffari Farhad 
Published: August 2015

AbstractA novel computational fluid dynamics (CFD) model was developed and validated with the experimental data to explore the effect of the agitator type, rotational speed, and the installation of baffles on the methyl methacrylate conversion, particle size and number of particles of poly methyl methacrylate (PMMA) produced in an emulsion polymerization reactor. The originality of this study was to include the reaction kinetics to the population balance through nucleation and growth rates while taking into account the velocity gradients generated by the impeller rotation inside the reactor. The number density achieved by the Rushton impeller was higher than that for the pitched blade impeller. The distribution of polymer volume fraction was more uniform with the pitched blade impeller than that for the Rushton impeller.
Accurate quantification of impurities in pure peptide material – angiotensin I: Comparison of calibration requirements and method performance characteristics of liquid chromatography coupled to hybrid tandem mass spectrometry and linear ion trap high‐resolution mass spectrometry
Authors: Stoppacher N. , Josephs R. D. , Daireaux A. , Choteau T. , Westwood S. , Wielgosz R. I. 
Published: August 2015

RationaleThe prohormone angiotensin I (ANG I) [amino acid sequence: DRVYIHPFHL] and other structurally related peptide hormones play an essential role in the regulation of the water and electrolyte balance in the human body as well as blood pressure. ANG I is a biomarker for hypertension and diabetes. Therefore, well‐characterized pure reference materials and comparable and SI‐traceable analytical characterization methods are required to establish reference measurement systems (RMS) for laboratory medicine.MethodsTwo analytical characterization methods based on liquid chromatography/mass spectrometry (LC/MS) systems with electrospray ionization have been developed and validated in‐house. Both high‐resolution MS (hrMS) and hybrid‐tandem MS/MS were used for the identification and quantification of the major structurally related peptide impurities of ANG I. The impurities were quantified by use of external calibrations with original impurity standards. Mass fraction impurity values and corresponding expanded measurement uncertainties were calculated.ResultsFive structurally related degradation products were detected as major impurities in a 'pure' ANG I material. The peptides ANG (2‐10) [RVYIHPFHL], ANG II [DRVYIHPF] and three ANG I isomers [DRVYLHPFHL, DRVYIHPFHI and DRVYLHPFHI] were identified and corresponding mass fraction values calculated that range from 0.66 to 4.86 mg/g.ConclusionsThe mass fraction values for the major related peptide impurities in the ANG I material obtained with both LC/hrMS and LC/MS/MS systems are in excellent agreement. This study emphasizes the importance of mass spectrometric techniques for application to mass balance approaches for mass fraction value and uncertainty assignment of impurities in 'pure' substance reference materials for peptides. Copyright © 2015 John Wiley & Sons, Ltd.
Peptide fragmentation caused by Ar cluster ions depending on primary ion energy
Authors: Aoyagi Satoka , Kawashima Tomoko , Yokoyama Yuta 
Published: August 2015

RationaleTime‐of‐flight secondary ion mass spectrometry (TOF‐SIMS) with an Ar cluster ion beam as a primary ion source provides useful information in terms of peptide analysis. It is, however, difficult to interpret the spectra. The ToF‐SIMS peptide spectra obtained with Ar clusters having different energies have been investigated in order to classify the secondary ions into the peptide fragment ions and those related to contaminants or the substrate.MethodsThree peptides having different molecular weights from 600 to 1300 u were measured with Ar cluster beams having different energies per atom from 4 to 40 eV/atom.ResultsIn the spectra normalized to a geometric average of all the spectra, the amino acid fragment ions are distinguished from other secondary ions. In the mass range above 600 u, the peptide fragment ions increase with mass while those not related to the peptide decrease with mass.ConclusionsEnergy‐dependence fragmentation helps in understanding the peptide spectra. Specific peptide fragment ions of the larger peptides are likely to be detected under lower energy than energy higher than 10 eV/atom. Although it is difficult to interpret the TOF‐SIMS spectra of a peptide obtained with an Ar cluster ion beam, the secondary ions can be classified by comparing those obtained with different energy Ar cluster ion beams. Copyright © 2015 John Wiley & Sons, Ltd.