bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disruption of mutated BRAF signaling modulates thyroid cancer phenotype
Authors: Hanly Elyse K , Rajoria Shilpi , Darzynkiewicz Zbigniew , Zhao Hong , Suriano Robert , Tuli Neha , George Andrea L , Bednarczyk Robert , Shin Edward J , Geliebter Jan , Tiwari Raj K 
Published: March 2014

Abstract

Background
Thyroid cancer is the most common endocrine-related cancer in the United States and its incidence is rising rapidly. Since among various genetic lesions identified in thyroid cancer, the BRAFV600E mutation is found in 50% of papillary thyroid cancers and 25% of anaplastic thyroid cancers, this mutation provides an opportunity for targeted drug therapy. Our laboratory evaluated cellular phenotypic effects in response to treatment with PLX4032, a BRAFV600E-specific inhibitor, in normal BRAF-wild-type thyroid cells and in BRAFV600E-positive papillary thyroid cancer cells.

Methods
Normal BRAF-wild-type thyroid cells and BRAFV600E-mutated papillary thyroid cancer cells were subjected to proliferation assays and analyzed for cell death by immunofluorescence. Cell cycle status was determined using an EdU uptake assay followed by laser scanning cytometry. In addition, expression of proteins within the MAPK signal transduction pathway was analyzed by Western blot.

Results
PLX4032 has potent anti-proliferative effects selectively in BRAF-mutated thyroid cancer cells. These effects appear to be mediated by the drug’s activity of inhibiting phosphorylation of signaling molecules downstream of BRAF within the pro-survival MAPK pathway. Interestingly, PLX4032 promotes the phosphorylation of these signaling molecules in BRAF-wild-type thyroid cells.

Conclusions
These findings support further evaluation of combinational therapy that includes BRAFV600E inhibitors in thyroid cancer patients harboring the BRAFV600E mutation.
Moving without a purpose: an experimental study of swarm guidance in the Western honey bee (Apis mellifera Linnaeus)
Authors: Makinson James C. , Beekman Madeleine 
Published: March 2014

Abstract
During reproductive swarming honey bee scouts perform two very important functions. Firstly, they find new nesting locations and return to the swarm cluster to communicate their discoveries. Secondly, once the swarm is ready to depart informed scout bees act as guides, leading the swarm to its final destination. We have previously hypothesised that the two processes, selecting a new nest site and swarm guidance, are tightly linked in honey bees. When swarms can be laissez faire about where they nest, reaching directional consensus prior to lift off seems unnecessary. If, on the other hand, it is essential that the swarm reaches a precise location, either directional consensus must be near unanimous prior to swarm departure or only a select subgroup of the scouts attempts to guide the swarm. Here we test experimentally if directional consensus is necessary for the successful guidance of swarms of the Western honey bee Apis mellifera by forcing swarms to the air prior to the completion of the decision-making process. Our results show that swarms were unable to guide themselves prior to the swarm reaching the pre-flight buzzing phase of the decision-making process, even when directional consensus was high. We therefore conclude that most likely not all scouts involved in the decision-making process attempt to guide the swarm.
Plato and Divination
Authors: Struck Peter 
Published: March 2014

Abstract Plato uses the idea of divinatory knowledge as a metaphorical descriptor for a variety of kinds of daytime, waking knowing. What unites these examples is that they all include discussion of a kind of knowing that cannot account for itself, and that is tentative, imagistic and non-discursive. These metaphorical uses can further be illuminated by his more detailed discussion of divinatory knowledge itself in Timeaus.
The Jews and their God of Wine
Authors: Kirkpatrick Jonathan 
Published: March 2014

AbstractIn the period between the two revolts of the Jews of Palestine against Roman rule some non-Jews sought to identify the God of the Jews with their own god of wine, Dionysus or Liber. The actual evidence suggests three things. The cult of the Temple at Jerusalem was seen by outsiders to be characterised by an association with, and the use of, wine, an impression Jews did nothing to counteract. Second, outsiders acted on this impression, both as part of the cognitive step of identifying the God of the Jews with Dionysus, and, possibly, making gifts to the Temple, while it stood, of wine-related dedications. Third, this was a characterisation Jews were willing to embrace themselves, even at times of revolt. It should be emphasised that there is no evidence for any change in actual Temple practice. The wine libations, presumably, were poured as prescribed with their sacrifices, and nobody drank of the libations, least of all the priests.
Paulus in Philippi: Ethik und Theologie
Authors: Becker Eve-Marie 
Published: March 2014

Abstract During his missionary activities in Asia Minor and Greece, Paul is continuously confronted with the ‘Gods of Others’. Interestingly enough, he is quite reluctant in reacting against his ‘pagan surroundings’-as Luke is in his portrayal of Paul (esp. Acts 16-17). On the basis of reconstructing Paul’s missionary activities in Philippi- a city which was most obviously characterized by ‘Romaness’ (romanitas)-and analyzing Phil 2:6-11-a core piece of Paul’s proclamation of ‘Christ’ -, this article argues that Paul was neither interested in anti-imperial polemics nor in the mythical construct of a ‘Christ-cult’. In order to react on his pagan surroundings in Macedonia and to make the ekklesia of Christ-believers attractive to its sympathizers, he rather uses a myth-historical text by which he teaches the ethos of Christ’s ‘Statusverzicht’ as a moral paradigm (exemplum): In pagan surroundings, Pauline theology thus finds its actual vanishing point in the discourse on ethics and ‘moral progress’.
Estradiol regulates insulin signaling and inflammation in adipose tissue
Authors: Shen Minqian , Kumar Shiva P.D. Senthil , Shi Haifei 
Published: March 2014

Abstract

Background: Obesity-associated low-grade inflammation at white adipose tissue (WAT) leads to metabolic defects. Sex steroid hormone estrogen may be protective against high-fat diet (HFD)-induced obesity and insulin resistance. This has been tested by many previous studies utilizing rodent models of ovariectomy (OVX) and/or treatment of estradiol (E2), the major biologically active form of estrogen. Body weight and adiposity are increased by OVX and reduced following E2 treatment, however. Thus, the protective roles of E2 may be secondary effects to the changes in body weight and adiposity. We hypothesize that E2 directly prevents inflammation and maintains insulin sensitivity in WAT independent of energy status using mice with similar body weights and adiposity.

Materials and methods: Four groups of female C57BL/6 mice were used, including sham-operated mice treated with vehicle for E2 and fed with either a low-fat diet (LFD; Sham-Veh-LFD) or a HFD (Sham-Veh-HFD), and HFD-fed OVX mice treated with either vehicle (OVX-Veh-HFD) or E2 (OVX-E2-HFD). Body weight and abdominal parametrial WAT mass, insulin signaling, and expression levels of genes related to low-grade inflammation in WAT were compared between these groups pair-fed with equal amounts of calories for a period of 4 days.

Results: Body weights and WAT mass were similar in all four groups. OVX-Veh-HFD mice had impaired insulin signaling associated with rapid activation of inflammation, whereas OVX-E2-HFD group maintained insulin sensitivity without showing inflammation in WAT.

Conclusions: E2 directly contributed to the maintenance of insulin sensitivity during the early phase of development of metabolic dysfunction, possibly via preventing low-grade inflammation in WAT.
Bosutinib in Combination With the Aromatase Inhibitor Exemestane: A Phase II Trial in Postmenopausal Women With Previously Treated Locally Advanced or Metastatic Hormone Receptor-Positive/HER2-Negative Breast Cancer
Authors: Moy Beverly , Neven Patrick , Lebrun Fabienne , Bellet Meritxell , Xu Binghe , Sarosiek Tomasz , Chow Louis , Goss Paul , Zacharchuk Charles , Leip Eric , Turnbull Kathleen , Bardy-Bouxin Nathalie , Duvillié Ladan , Láng István 
Published: March 2014

Abstract

Author Summary

Background.
Bosutinib is an oral, selective Src/Abl tyrosine kinase inhibitor with activity in breast cancer (BC). We evaluated bosutinib plus exemestane as second-line therapy in previously treated hormone receptor-positive (HR+) locally advanced or metastatic BC.

Methods.
This was a phase II study with patients enrolled in a single-arm safety lead-in phase. Patients receiving bosutinib at 400 mg or 300 mg/day (based on toxicity) plus exemestane at 25 mg/day were monitored for adverse events (AEs) and dose-limiting toxicities for 28 days, and initial efficacy was assessed. After the lead-in and dose-determination phase, randomized evaluation of combination therapy versus exemestane was planned.

Results.
Thirty-nine of 42 patients (93%) experienced treatment-related AEs including diarrhea in 28 (67%) and hepatotoxicity in 11 (26%); overall serious treatment-related AEs were recorded in 4 (10%). No liver toxicity met Hy's law criteria. Dose-limiting toxicities occurred in 5 of 13 patients receiving 400 mg (38%) and 3 of 26 patients receiving 300 mg (12%) of bosutinib; all resolved on treatment discontinuation. One patient (300 mg/day) achieved confirmed partial response; three (400 mg/day, n = 2; 300 mg/day, n = 1) maintained stable disease for &gt;24 weeks; a best response of progressive disease occurred in 15 of 42 patients (36%). Median progression-free survival was 12.3 weeks (80% confidence interval: 11.0–15.6).

Conclusion.
The risk-benefit profile of bosutinib at 300 mg/day plus exemestane resulted in early study termination before the randomized portion. Alternative bosutinib regimens merit investigation in BC.
The added value of the electrical neuroimaging for the evaluation of marketing stimuli
Authors: Vecchiato G. , Toppi J. , Astolfi L. , Cincotti F. , De Vico Fallani F. , Maglione A.G. , Borghini G. , Cherubino P. , Mattia D. , Babiloni F. 
Published: March 2014

Abstract
There is a large interest in the marketing world to use the neuroimaging tools as a possible aid to evaluate the efficacy of a commercial advertisement. Such an area of study is called “neuromarketing”. Here we illustrate some applications of electrical neuroimaging, a discipline using EEG and intensive signal processing techniques for the evaluation of such marketing stimuli. We will show which kind of information is possible to gather with these methodologies while persons are watching marketing relevant stimuli. Such information is related to the memorization and attention of commercial advertisements. We noted that temporal and frequency patterns of EEG signals are able to return descriptors of cognitive process in subjects that watched such commercial announcements. The described EEG methodologies could be then employed both to better design new products that are going to be promoted on the market as well as to analyse the global cognitive impact of commercial videos already broadcasted.
A comparison of algorithms for separation of synchronous subspaces
Authors: Almeida M. , Bioucas-Dias J. , Vigário R. , Oja E. 
Published: March 2014

Abstract
Independent Subspace Analysis (ISA) consists in separating sets (subspaces) of dependent sources, with different sets being independent of each other. While a few algorithms have been proposed to solve this problem, they are all completely general in the sense that they do not make any assumptions on the intra-subspace dependency. In this paper, we address the ISA problem in the specific context of Separation of Synchronous Sources (SSS), i.e., we aim to solve the ISA problem when the intra-subspace dependency is known to be perfect phase synchrony between all sources in that subspace. We compare multiple algorithmic solutions for this problem, by analyzing their performance on an MEG-like dataset.
Closed-loop control algorithm for some class of nonholonomic systems using polar representation
Authors: Pazderski D. , Szulczyński P. , Kozłowski K. 
Published: March 2014

Abstract
This paper is focused on the convergence problem defined for some class of a two input affine nonholonomic driftless system with three-dimensional state. The problem is solved based on a polar transformation which is singular at the origin. The convergence is ensured using static-state feedback. The necessary conditions for construction of the algorithm are formally discussed. The solution, in general, is local, and the feasible domain is strictly related to the properties of the control system. In order to improve algorithm robustness a simple hybrid algorithm is formulated. The general theory is illustrated by two particular systems and the results of numerical simulations are provided.
Control of a unicycle-like robot with trailers using transverse function approach
Authors: Pazderski D. , Kozłowski K. , Waśkowicz D.K. 
Published: March 2014

Abstract
The paper presents the application of a smooth kinematic algorithm to control multi-body vehicle which consists of the unicyclelike tractor with three trailers. The controller takes advantage of the transverse functions and properties of the IV-order two input chained system. The derivation of the algorithm is presented in details. In order to improve the performance of the controller in the real application a selected tuning techniques are discussed. The properties of the closed-loop control system are examined based on results of numerical simulations concerning the point stabilization and trajectory tracking tasks.
Analysis of actual accuracy in cardiac output measurements by means of thermodilution
Authors: Gawlikowski M. , Pustelny T. 
Published: March 2014

Abstract
The essential examination in hemodynamic monitoring of the patient is the cardiac output (CO) measurement. Nowadays, in clinical practice the most popular method is indicator dilution, particularly thermodilution. It is realized by applying the Swan-Ganz catheter and observing changes of the indicator concentration. This method is sensitive to many factors and the obtained results should be treated cautiously. The paper presents theoretical and experimental studies of metrological phenomena in CO measurements by means of thermodilution, paying special attention to medical aspects of the measurements. It has been pointed out that the actual unreliability of the mentioned method reaches values from 20% to 45%, which is in opposition to the technical data of patient’s monitors (typical accuracy about 5%).
Positive stable realizations of discrete-time linear systems
Authors: Kaczorek T. 
Published: March 2014

Abstract
The problem of existence and determination of the set of positive asymptotically stable realizations of a proper transfer function of linear discrete-time systems is formulated and solved. Necessary and sufficient conditions for existence of the set of the realizations are established. A procedure for computation of the set of realizations are proposed and illustrated by numerical examples.
Active optical fibres for application in laser and broadband ASE sources
Authors: Dorosz D. , Dorosz J. , Zając A. , Żmojda J. , Kochanowicz M. 
Published: March 2014

Abstract
The article brings into focus the present state of technology employing active fibres doped with rare earth (RE) ions for applications requiring power supply of several dozen watts and broadband ASE sources. Current trends in development of glasses and in construction of active fibres used in fibre sources of radiation within VIS-NIR range are presented. Technological constraints in the doping of fibre core glasses are discussed, with particular consideration of optimal RE concentration for technical applications. Characteristics of glasses are offered, and the glasses are used for manufacturing optical fibres with luminescence within the visible as well as near- and mid-infrared ranges. Also, requirements and luminescence properties concerning glasses co-doped with e.g. Nd3+/Yb3+,Tm3+/Ho3+ and Yb3+/Tb3+ are discussed. Results of research on the impact of technological parameters of glass matrices on luminescence properties of core glasses and optical fibres are quoted. For the doped glasses of which luminescence in a wide spectral range is desired, conditions for their processing into optical fibre systems are mentioned. Additionally, the impact of phonon energy in the glass on producing emission in a specified spectral range is analyzed. Furthermore, the article presents directions of technological studies to solve problems persisting in the phase of glass matrix design, as well as in determining the influence of fibre drawing process on the luminescence properties of core glasses and optical fibres, confirming the differences in luminescence stemming from the drawing process. Finally, some original designs of core glasses and active multicore fibre systems devised for construction of fibre radiation sources are presented.
Lasers in the dual use technologies
Authors: Mierczyk Z. 
Published: March 2014

Abstract
In the more developed countries the use of modern technologies in the national economy is a general process allowing joint funding of a security research and development by both sources, state and private. The last one is especially involved in applications of modern technologies. One of the examples of important modern technologies being under development in many countries are dual-use technologies, which include IT technologies, sensors, effective energy sources, material science, nanotechnology, micro- and nano-electronics, photonics, biotechnology and quantum medicine. In this paper chosen technologies fulfilling the needs of the military technique and security monitoring systems, which have found their applications in the different branches of industry like power engineering, transportation, construction industry, metrology, protection of environment and the medicine, are discussed. The examples include the devices and lasers systems for different threats monitoring, which have been developed at the Military University of Technology. The research studies carried out on the analysis of various materials based on their spectroscopic characteristics: absorption, emission, dispersion, polarization and fluorescence in different mediums have led to the development of laser telemetry devices, environment monitoring devices and spatial imagery, as well as devices for medical diagnostics and therapy. Mentioned systems are composed of functional modules, which were developed to meet the real needs. These systems can be expanded further by addition of extra detectors of chemical materials and physical properties, and improving measuring functions and data transmission and processing.
Fiber-based laser frequency combs
Authors: Soboń G. , Abramski K.M. 
Published: March 2014

Abstract
For the last decade a very attractive field of laser physics, namely the optical frequency comb technique, has been intensively developed. Fiber lasers play particular role in that area. The motivation of their development is obtaining broadband comb systems with well-defined and stable mods (comb teeth). This paper presents a basic overview devoted to the fiber-based optical frequency combs.
A reconfigurable structure electronic commutator for a dual BLDC motor EV drive
Authors: Biskup T. , Bodora A. , Domoracki A. 
Published: March 2014

Abstract
An electronic commutator that can drive a PM BLDC motor either in the full bridge or half bridge configuration has been developed. This commutator allows increasing the motor speed over the nominal value, hence the motor is able to operate within a wide constant power speed range. An application of the commutator with a reconfigurable structure for the double drive of a small electric vehicle Elipsa has been presented. The driveline consists of two independent commutators feeding the motors coupled by gears with rear wheels of the vehicle. Both commutators are controlled by a common control system based on a signal microcontroller. The results of road tests indicate new areas of BLCD motor drives application. The fact that the BLCD motor work in the second speed range does not require any changes in the motor construction and at the same time does not significantly deteriorate the drive efficiency is an indisputable advantage of the presented solution
Numerical simulations of acoustic waves with the graphic acceleration GAMER code
Authors: Murawski K. , Murawski K. , Schive H.-Y. 
Published: March 2014

Abstract
We present results of numerical simulations of acoustic waves with the use of the Graphics Processing Unit (GPU) acceleration GAMER code which implements a second-order Godunov-type numerical scheme and adaptive mesh refinement (AMR). The AMR implementation is based on constructing a hierarchy of grid patches with an octree data structure. In this code a hybrid model is adopted, in which the time-consuming solvers are dealt with GPUs and the complex AMR data structure is manipulated by Central Processing Units (CPUs). The code is highly parallelized with the Hilbert space-filling curve method. These implementations allow us to resolve well desperate spatial scales that are associated with acoustic waves. We show that a localized velocity (gas pressure) pulse that is initially launched within a uniform and still medium triggers acoustic waves simultaneously with a vortex (an entropy mode). In a flowing medium, acoustic waves experience amplitude growth or decay, a scenario which depends on a location of the flow and relative direction of wave propagation. The amplitude growth results from instabilities which are associated with negative energy waves.
Simple analytic conditions for stability of fractional discrete-time linear systems with diagonal state matrix
Authors: Busłowicz M. 
Published: March 2014

Abstract
In the paper the problems of practical stability and asymptotic stability of fractional discrete-time linear systems with a diagonal state matrix are addressed. Standard and positive systems are considered. Simple necessary and sufficient analytic conditions for practical stability and for asymptotic stability are established. The considerations are illustrated by numerical examples.
Influence of the stator winding resistance on the field-weakening operation of the DRFOC induction motor drive
Authors: Nguyen-Thac K. , Orlowska-Kowalska T. , Tarchala G. 
Published: March 2014

Abstract
In this paper, an analysis of the influence of the stator winding resistance on the field-weakening operation of the induction motor drive based on the Direct Rotor Flux Oriented Control (DRFOC) is presented. Two scenarions of the optimal field-weakening algorithm (with and without stator winding resistance taken into account) have been compared and verified through simulation and experiment, under different operation conditions of the DRFOC drive system with 3 [kW] induction motor.
Positive realizations with reduced numbers of delays for 2D continuous-discrete linear systems
Authors: Kaczorek T. 
Published: March 2014

Abstract
A new method is proposed for determination of positive realizations with reduced numbers of delays of linear 2D continuousdiscrete systems. Sufficient conditions for the existence of the positive realizations of a given proper transfer function are established. It is shown that there exists a positive realization with reduced numbers of delays if there exists a positive realization without delays but with a greater dimension. The proposed method is demonstrated on a numerical example.