bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soil conservation and water conservation services and trade-offs following the land consolidation project: a case study of Yan’an city, China
Authors: Jing Wang , Yang Zhang , Longfei Xia , Jianfeng Li , Huan He , Siqi Liu 
Published: August 2024

The Loess Plateau is an important region for soil and water conservation and ecological construction in China. Exploring the spatio-temporal variations in soil conservation and water conservation services and their relationships in Loess Plateau under the background of land consolidation projects is of great significance for ecological protection and quality development in the Yellow River Basin. Taking Yan’an city as the research area, this paper used the InVEST model to quantitatively evaluated spatio-temporal variation characteristics and trade-off/synergy relationship of the soil conservation and water conservation services from 2010 to 2018. According to the implementation data, the relationship between the gully control and land consolidation (GCLC) project in various counties of Yan’an city and soil conservation and water conservation service was analyzed. The results showed that the total amount of soil conservation services in Yan’an City were 4.07 × 106 t and 3.75 × 106 t in 2010 and 2018 with a decrease of 7.76%, and with low spatial clustering characteristic. The total amount of water conservation services were 2.01 × 1010 mm and 2.03 × 1010 mm in 2010 and 2018 with a increase of 0.56%, and with high spatial clustering characteristic. There is a synergistic relationship between soil conservation and water conservation services in most area of Yan’an city. From 2010 to 2018, the effect of the GCLC projects on soil conservation and water conservation services in Yan’an city is not significant. The GCLC project can effectively alleviate the situation of sharp decline of cultivated land area and insufficient food production capacity.
Development and validation of a hypoxia- and mitochondrial dysfunction- related prognostic model based on integrated single-cell and bulk RNA sequencing analyses in gastric cancer
Authors: Li Yirong , Cui Yue , Wang Zhen , Wang Liwei , Yu Yi , Xiong Yuyan 
Published: August 2024

IntroductionGastric cancer (GC) remains a major global health threat ranking as the fifth most prevalent cancer. Hypoxia, a characteristic feature of solid tumors, significantly contributes to the malignant progression of GC. Mitochondria are the major target of hypoxic injury that promotes mitochondrial dysfunction during the development of cancers including GC. However, the gene signature and prognostic model based on hypoxia- and mitochondrial dysfunction-related genes (HMDRGs) in the prediction of GC prognosis have not yet been established.MethodsThe gene expression profile datasets of stomach cancer patients were retrieved from The Cancer Genome Atlas and the Gene Expression Omnibus databases. Prognostic genes were selected using Least Absolute Shrinkage and Selection Operator Cox (LASSO-Cox) regression analysis to construct a prognostic model. Immune infiltration was evaluated through ESTIMATE, CIBERSORT, and ssGSEA analyses. Tumor immune dysfunction and exclusion (TIDE) and immunophenoscore (IPS) were utilized to explore implications for immunotherapy. Furthermore, in vitro experiments were conducted to validate the functional roles of HMDRGs in GC cell malignancy.ResultsIn this study, five HMDRGs (ZFP36, SERPINE1, DUSP1, CAV1, and AKAP12) were identified for developing a prognostic model in GC. This model stratifies GC patients into high- and low-risk groups based on median risk scores. A nomogram predicting overall survival (OS) was constructed and showed consistent results with observed OS. Immune infiltration analysis indicated that individuals in the high-risk group tend to exhibit increased immune cell infiltration. Additionally, analysis of cancer immunotherapy responses revealed that high-risk group patients exhibit poorer responses to cancer immunotherapy compared to the low-risk group. Immunohistochemistry (IHC) staining indicated that the expression levels of HMDRGs were remarkably correlated with GC, of which, SERPINE1 displayed the most pronounced up-regulation, while ZFP36 exhibited the most notable down-regulation in GC patients. Furthermore, in vitro investigation validated that SERPINE1 and ZFP36 contribute to the malignant processes of GC cells correlated with mitochondrial dysfunction.ConclusionsThis study presents a novel and efficient approach to evaluate GC prognosis and immunotherapy efficacy, and also provides insights into understanding the pathogenesis of GC.
Situational crime analysis of poaching within Territorial Use Rights Fisheries (TURFs)
Authors: Vallejos Tomás , Nahuelhual Laura , Gelcich Stefan , Oyanedel Rodrigo 
Published: August 2024

IntroductionIllegal, unreported, and unregulated (IUU) fishing poses a significant threat to marine resource management globally. Environmental criminology plays a vital role in understanding and mitigating IUU activities by focusing on the contextual elements surrounding these crimes. This study examines the dynamics of poaching within areas managed through Territorial User Rights for Fisheries (TURFs), with a specific emphasis on the loco (Concholepas concholepas) fishery in Chile.MethodsEmploying Crime Script Analysis (CSA) as the primary methodological lens, this research meticulously deconstructs the criminal process involved in TURFs poaching operations. CSA is used to identify key elements, providing a comprehensive understanding of poachers modus operandi. Additionally, by integrating CSA with Situational Precipitators of Crime (SPC), the study identifies critical factors such as environmental conditions, socio-economic disparities, and enforcement weaknesses that shape poaching opportunities within TURFs. ResultsThe analysis reveals a complex interplay between SPC factors, underscoring their role in shaping poaching dynamics. Key findings highlight the importance of specific environmental conditions, socio-economic disparities, and enforcement weaknesses in facilitating poaching activities. The study identifies various tactics and strategies employed by poachers and the roles of different actors involved in the poaching process. DiscussionBuilding upon these findings, the study proposes a comprehensive Situational Crime Prevention (SCP) framework aimed at effectively combating TURFs poaching. The framework emphasizes the importance of striking a careful balance between restrictive and inclusive measures to mitigate potential negative consequences. The study contributes valuable insights into understanding and addressing IUU fishing, particularly within TURFs in Chile.
Physical activity levels during COVID-19 pandemic and its associated factors in patients with Chagas disease
Authors: Xavier Isis Gabrielli Gomes , Andrade Patrícia Mello , Vitor Rodrigo de Lima , Barros Tayná Cruz , Portela Luciana Fernandes , de Holanda Marcelo Teixeira , Sangenis Luiz Henrique Conde , Sperandio da Silva Gilberto Marcelo , Mazzoli-Rocha Flavia , Mendes Fernanda de Souza Nogueira Sardinha , da Costa Andréa Rodrigues , Quintana Marcel de Souza Borges , Hasslocher-Moreno Alejandro Marcel , Araujo Itauá Leston , Junqueira Angela Cristina Verissimo , Pinheiro Roberta Olmo , Georg Ingebourg , Paravidino Vitor Barreto , Gonçalves Tatiana Rehder , Saraiva Roberto Magalhães , Mediano Mauro Felippe Felix 
Published: August 2024

BackgroundA better understanding of the consequences of the Coronavirus Disease 2019 (COVID-19) pandemic on lifestyle of patients with Chagas disease (ChD) is of paramount importance to facilitate the implementation of intervention strategies tailored to this specific population.ObjectiveThe present study aimed to evaluate the level of physical activity (PA) in Chagas disease (ChD) patients during the Coronavirus Disease 2019 (COVID-19) pandemic and its main associated factors.MethodsThis is a cross-sectional study with 187 patients of both sexes, aged ≥18 years, followed in a national infectious disease center (Rio de Janeiro, Brazil). The level of PA was determined by the International Physical Activity Questionnaire short version and expressed in terms of total volume of physical activity (PA) (MET-minutes per week). Individuals were classified as physically active following the 2020 World Health Organization PA guideline. The exposure variables were age, sex, race, marital status, schooling, income per capita, number of rooms per domicile, number of residents per domicile, body mass index, clinical form of ChD, COVID-19 antibodies, comorbidities, self-reported anxiety, self-reported depression, self-reported fear, and self-reported sadness. The association between the exposure variables with total PA (as a continuous variable) was determined using univariate and multivariate linear regression models.ResultsMean age was 61.1 ± 11.6 years. Most (62%) were women and self-declared their race as mixed (50.8%). The percentage of physically active individuals according to was 52%. The variables independently associated with total PA levels were non-white race (Exp β = 1.39; 95% CI 1.02 to 1.90), dyslipidemia (Exp β = 0.73; 95% CI 0.56 to 0.95) and self-reported depression during quarantine (Exp β = 0.71; 95% CI 0.52 to 0.96).ConclusionNon-white race was positively associated with total levels of PA, while dyslipidemia, and self-reported depression during quarantine were negatively associated with total levels of PA. The identification of associated factors can facilitate the development of tailored strategies to increase PA levels ChD patients.
Relationship between enteral nutrition timing and 28-day mortality in critically ill stroke patients in the MIMIC-IV database
Authors: Wang Xiaoliang , Xie Xiuling , Xu Xin , Tan Lan 
Published: August 2024

BackgroundThe ideal timing for commencing enteral nutrition (EN) in critically ill stroke patients in the intensive care unit (ICU) remains a subject of debate, with ongoing controversy regarding the impact of early EN (EEN) initiation. In this study, we investigated the association between the timing of EN initiation and 28-day mortality using data from the MIMIC-IV database.MethodsThis study employed a retrospective cohort design using the MIMIC-IV database to identify stroke patients who received EN during their hospital stay. The main focus of this investigation was to examine 28-day mortality among these patients following hospital admission. Various demographic, clinical, laboratory, and intervention variables were considered as covariates. The Cox regression analysis was employed to assess the correlation between the timing of EN initiation and 28-day mortality, and restricted cubic splines (RCS) analysis was used to test for non-linear correlation. Patients were then stratified into two cohorts depending on the timing of EN initiation: within 2 days (n = 564) and beyond 2 days (n = 433). A multivariate Cox regression analysis was used to investigate the difference in 28-day mortality between the groups.ResultsA total of 997 participants were included in this study, with 318 (31.9%) dying within 28 days. We observed that the timing of EN initiation correlated with 28-day mortality, but this correlation was not significant after adjusting for covariates (crude HR: 0.94, 95% CI: 0.88–1, p = 0.044; adjusted HR: 0.96, 95% CI: 0.9–1.02, p = 0.178). The RCS analysis showed that the correlation was not non-linear. Notably, in the multivariate regression models, early EN initiation was associated with a higher mortality rate compared to late EN initiation [odds ratio (OR) = 1.34, 95% CI: 1.06–1.67, p = 0.012]. After adjusting for various confounding factors in the multivariate Cox regression models, we identified that patients in the early EN group had a 28% higher risk of mortality than those in the reference group (OR = 1.27, 95% CI: 1–1.61, p = 0.048). These associations remained consistent across various patient characteristics, as revealed through stratified analyses.ConclusionsEarly commencement of EN in critically ill stroke patients may be linked to a higher risk of 28-day mortality, highlighting the need for further investigation and a more nuanced consideration of the optimal timing for commencing EN in this patient population.
Treatment patterns of patients with migraine eligible for anti-CGRP pathway monoclonal antibodies
Authors: Khodavirdi Ani C. , Multani Jasjit K. , Oh Sam S. , Vuvu Fiston , Bensink Mark E. , Stockl Karen M. , Hawkins Kevin , Chiang Chia-Chun , Green A. Laine , Tepper Stewart J. 
Published: August 2024

IntroductionMigraine is a debilitating neurological disorder, with a wide range of symptoms and disease burden, underscoring the heterogeneity of patients’ disease characteristics and treatment needs. To characterize the profile of migraine patients in the US who may be eligible for preventive treatment with an anti-CGRP pathway mAb and to better understand treatment patterns and real-world use of acute and preventive medications for migraine, we conducted a retrospective cohort study of adult patients.MethodsThese patients were identified as having migraine using diagnosis codes or migraine-specific medication use (first = index) in the IQVIA PharMetrics® Plus database. Patients were required to have ≥ 12 months of continuous enrollment in medical and pharmacy benefits prior to index (baseline) and after index (follow-up). Patients were stratified into chronic migraine (CM) and non-chronic migraine (non-CM) by diagnosis codes. Based on acute migraine-specific medication dispensing data in the follow-up period, non-CM patients were divided into 3 cohorts: highest, middle, and lowest tertile of total units of dispensed acute migraine-specific medication (gepants, ditans, ergot derivatives, and triptans). Migraine medication use was captured in the baseline and follow-up periods.ResultsA total of 22,584 CM and 216,807 non-CM patients (72,269 patients in each tertile) were identified and included in the study. Over the follow-up, CM patients had a mean of 70 units of acute migraine-specific medications dispensed, while the highest, middle, and lowest tertile of non-CM patients had a mean of 92, 29, and 10 units, respectively. Anti-calcitonin gene-related peptide pathway mAbs were dispensed for 28.9% of CM patients, and for 6.9%, 4.1%, and 2.9% of non-CM patients in the highest, middle, and lowest tertiles, respectively.ConclusionA lower proportion of non-CM patients had use of anti-calcitonin gene-related peptide pathway mAbs compared to CM patients, confirming the unmet need with appropriate preventive medication. There appears to be a persistent gap in management of patients without a diagnosis of CM who are dispensed high quantities of acute migraine-specific medications.
Enteral tube feeding practices and associated factors among nurses working in South Wollo Zone Specialized and General Hospitals, Wollo, Ethiopia, 2022
Authors: Ahmed Ali , Anteneh Samuel , Hussien Adem , Seid Anwar , Semanew Yaregal 
Published: August 2024

BackgroundEnteral tube feeding is recommended as a route for nutrient delivery in critically ill patients. The practice of enteral tube feeding by nurses significantly influences patient treatment outcomes. Therefore, this study aimed to identify the practices of enteral tube feeding and the associated factors among nurses working in South Wollo Zone Specialized and General Hospitals, Wollo, Ethiopia, 2022.MethodsA hospital-based cross-sectional study design was conducted on 420 nurses from 1st August to 1st September 2022. Simple random sampling methods were used to select study participants. Data were collected using self-administered questionnaires and an observational checklist. The data were entered into Epi Data version 4.6 and analyzed using SPSS version 26. Variables with a p-value &lt;0.05, a 95% confidence interval, and an adjusted odd ratio were considered to be significantly associated with enteral tube feeding practice.ResultA total of 400 nurses participated in the study, yielding a 95.2% response rate. The overall good practice of enteral tube feeding among nurses was 114 (28.5%) with a 95% CI of 23.8–33. Enteral tube feeding practice was significantly associated with a lack of adequate resources (AOR = 0.359, 95% CI: 0.192–0.673), unfamiliarity with current guidelines (AOR = 0.346, 95% CI: 0.203–0.586), lack of awareness (AOR = 0.511, 95% CI: 0.306–0.673) and the thermal effect of food (AOR = 0.56, 95% CI: 0.348–0.889).ConclusionThe enteral tube feeding practice among nurses was found to be 28.5%. Significant determinants of enteral tube feeding practice included a lack of awareness, inadequate resources in the institution, and unfamiliarity with the current guidelines for enteral feeding. To improve enteral feeding practices, it is recommended that sufficient resources be provided, guidelines be made readily available, and training programs be conducted for the nursing staff.
Vitamin A supplementation status and associated factors among children aged 6–59 months in Tanzania: a multi-level analysis
Authors: Gebrekidan Amanuel Yosef , Asgedom Yordanos Sisay , Woldegeorgis Beshada Zerfu , Kassie Gizachew Ambaw , Haile Kirubel Eshetu , Damtew Solomon Abrha , Teklay Ashenafi , Ayele Amare Demsie 
Published: August 2024

BackgroundVitamin A supplementation every 4–6 months is an economical, rapid, and effective strategy to enhance vitamin A status and minimize child morbidity and mortality due to vitamin A deficiency in the long run. Therefore, this study was aimed at investigating the level as well as the factors influencing VAS status among children aged 6–59 months in Tanzania.MethodsThis analysis relied on data from the 2022 Tanzania Demographic and Health Survey (TDHS). The study used a weighted sample of 9,382 children aged 6–59 months. Given the effect of clustering and the binary character of the outcome variable, we employed a multilevel binary logistic regression model. The adjusted odds ratio (AOR) with a 95% confidence interval (CI) was used to determine statistical significance, considering the model with the lowest deviation that best fits the data.ResultsIn this study, vitamin A supplementation among children aged 6–59 months was found to be 53.18% [95% CI: 52.17, 54.19]. Mother’s/caregiver’s working status; Working [AOR = 1.59, 95% CI: 1.34, 1.89], ANC follow-up [AOR = 1.71, 95%CI: 1.34, 2.2], and health facility delivery [AOR = 1.55, 95%CI: 1.25, 1.91] were individual-level factors associated with vitamin A supplementation. Whereas administrative zones of Western [AOR = 2.02, 95% CI: 1.16, 3.52], Southern highlands [AOR = 3.83, 95% CI: 2.02, 7.24], Southern administrative zone [AOR = 2.69, 95% CI: 1.37, 5.3], and South West highlands [AOR = 0.56, 95% CI: 0.33, 0.95] were community-level factors associated with vitamin A supplementation.ConclusionThe proportion of VAS among children in Tanzania is low compared to UNICEF’s target of 80. Mother’s/caregiver’s working status, antenatal care, place of delivery, community-level media exposure, and administrative zones were significantly associated factors with vitamin A supplementation. Therefore, interventions should be designed to improve the uptake of VAS. Provision and promotion of ANC and institutional delivery and strengthening of routine supplementation are recommended to increase coverage of childhood vitamin A supplementation. Moreover, special focus should be given to regions in the south-western highlands.
Long-term survival of a patient with gastric cancer with bone marrow metastasis receiving S-1 plus oxaliplatin beyond three years: a case report and literature review
Authors: Suto Hirotaka , Inui Yumiko , Okamura Atsuo 
Published: August 2024

BackgroundBone marrow metastasis (BMM) of gastric cancer (GC), which is the most common cause of disseminated intravascular coagulation (DIC) among solid tumors, has a poor prognosis. Studies on prognostic improvement beyond one year in patients with GC with BMM are limited. This is the first report of a patient who survived over three years after 30 months of S-1 plus oxaliplatin (SOX) therapy for GC with BMM.Case ReportThe patient was a 72-year-old woman who presented with anemia and high levels of alkaline phosphatase (ALP) and carbohydrate antigen 19-9 (CA19-9). Detailed examination led to the diagnosis with BMM of GC uncomplicated by DIC and the SOX regimen was initiated in November 2018. After six cycles, she was switched to S-1 monotherapy, and both ALP and CA19-9 levels reached normal by November 2019. However, computed tomography in April 2021 showed multiple bone metastases. Therefore, she was switched to paclitaxel-based therapy. In November 2021, the patient was further switched to nivolumab monotherapy, but she succumbed due to DIC in March 2022.ConclusionGCs with BMM are prone to DIC, and the SOX regimen, which includes S-1 with efficacy against micrometastases, may constitute a safe and effective treatment modality.
Addressing the links between and internal vs. external regulation factors, achievement emotions and gender in problematic use of ICT at university
Authors: de la Fuente Jesús , Lecuona-López Leyre , Pachón-Basallo Mónica , San Martín-Íñiguez Leyre , Blanco-Sarto Pablo 
Published: August 2024

ContextThe study of internal and external regulation in the use of Information and Communications Technology (ICT) and the analysis of academic emotions have become increasingly important due to their impact on academic life at university.ObjectivesThis research aims to investigate the links between internal vs. external regulation factors, achievement emotions, and gender in the problematic use of ICT among university students.MethodologyThe study recruited 317 university students, predominantly female (72.51%), using an ex-post facto design. The SRT-ERT scale was used to assess technology-related behaviors, and the AEQ Scales measured academic emotions before, during, and after class. Correlation analysis, multiple regression analysis, and ANOVA were employed to identify significant relationships.ResultsSignificant relationships were identified between regulatory behaviors, with male students exhibiting more dysregulated behavior and greater exposure to dysregulatory technology environments. Individual and contextual behavioral nonregulation and dysregulation in the use of ICT were significantly predictive of negative academic emotions.ConclusionThe findings suggest that both personal and contextual factors of regulation significantly influence the emotional experiences of students in academic settings. The study highlights the need for psycho-educational interventions to promote better regulatory behaviors among university students, particularly males.