bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions to improve screening and appropriate referral of patients with cancer for distress: systematic review protocol
Authors: McCarter Kristen , Britton Ben , Baker Amanda , Halpin Sean , Beck Alison , Carter Gregory , Wratten Chris , Bauer Judy , Booth Debbie , Forbes Erin , Wolfenden Luke 
Published: September 2015

IntroductionIt is estimated that 35–40% of patients with cancer experience distress at some stage during their illness. Distress may affect functioning, capacity to cope, treatment compliance, quality of life and survival of patients with cancer. Best practice clinical guidelines recommend routine psychosocial distress screening and referral for further assessment and/or psychosocial support for patients with cancer. However, evidence suggests this care is not provided consistently.Methods and analysisWe developed our methods following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. The review is registered with PROSPERO and any amendments to the protocol will be tracked. The primary aim of this systematic review is to examine the impact of interventions delivered in healthcare settings that are aimed at (1) improving routine screening of patients for psychosocial distress and (2) referral of distressed patients with cancer for further assessment and/or psychosocial support. The effectiveness of such interventions in reducing psychosocial distress, and any unintended adverse effect of the intervention will also be assessed in patients with cancer. Data sources will include the bibliographic databases Cochrane Central Register of Controlled trials (CENTRAL) in the Cochrane Library, MEDLINE, EMBASE, PsycINFO and CINAHL. Eligible studies must compare an intervention (or two or more interventions) in a healthcare setting to improve the rate of screening for psychosocial distress and/or referral for further assessment and/or psychosocial support for patients with cancer with no intervention or ‘usual’ practice. Two investigators will independently review titles and abstracts, followed by full article reviews and data extraction. Disagreements will be resolved by consensus and if necessary, a third reviewer. Where studies are sufficiently homogenous, trial data will be pooled and meta-analyses performed.Ethics and disseminationNo ethical issues are foreseen. The findings of this study will be disseminated widely via peer-reviewed publications and conference presentations.Systematic review registrationPROSPERO registration number CRD4 2015017518.
Final results of the US humanitarian device exemption study of the low-profile visualized intraluminal support (LVIS) device
Authors: Fiorella David , Arthur Adam , Boulos Alan , Diaz Orlando , Jabbour Pascal , Pride Lee , Turk Aquilla S , Woo Henry H , Derdeyn Colin , Millar John , Clifton Andrew 
Published: September 2015

IntroductionThe low-profile visualized intraluminal support (LVIS) device is a new, braided, intracranial microstent designed for stent-assisted coiling.ObjectiveTo present the results of a single-arm, prospective, multicenter trial of the LVIS for treatment of wide-necked intracranial aneurysms.Methods31 patients with unruptured, wide-necked (neck ≥4 mm or dome:neck ratio ≤2) intracranial aneurysms were treated with the LVIS device and bare platinum coils at six US centers (investigational device exemption G110014). Clinical follow-up was conducted at 30 days and 6 months. Angiographic follow-up was performed at 6 months. The primary safety endpoint was any major stroke or death within 30 days or major ipsilateral stroke or neurological death within 6 months. ‘Probable benefit’ was defined as ≥90% angiographic occlusion at 6 months. An independent core laboratory adjudicated the angiographic results. An independent clinical events committee adjudicated the clinical endpoints.ResultsAverage aneurysm size was 7.2 mm (SD 3.8) and average neck width was 4.6 mm (SD 1.8). 68% of patients had a dome:neck ratio ≤2. LVIS placement was technically successful in 29/31 patients (93.5%). No primary safety endpoints occurred during the study (0%). No patient had a higher modified Rankin Score at 6 months than at baseline. 26/28 (92.9%) treated aneurysms with 6-month angiographic follow-up demonstrated ≥90% angiographic occlusion. 21/28 (75%) were completely occluded at follow-up.ConclusionsThe LVIS device facilitated the coil embolization of wide-necked intracranial aneurysms with high rates of technical success, an excellent safety profile, and very high rates of complete and near-complete occlusion at follow-up.Trial registration numberNCT01541254.
Crystal structure, dielectric, ferroelectric and energy storage properties of La-doped BaTiO3 semiconducting ceramics
Authors: Puli Venkata Sreenivas , Li Patrick , Adireddy Shiva , Chrisey Douglas B. 
Published: September 2015

Polycrystalline La-doped [Formula: see text] [Formula: see text] [[Formula: see text]] ceramics (denoted as BTO,BLT1,BLT2,BLT3) were synthesized by conventional solid-state reaction method and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and Raman spectroscopy. XRD and Raman spectra revealed single-phase tetragonal perovskite crystalline structure. Well-saturated polarization–electric field ([Formula: see text]) hysteresis loops were observed with the measurement frequency of 50 Hz at room temperature and confirmed ferroelectric nature of these ceramics and a high recoverable electrical energy storage density of 0.350 J/cm3 with energy efficiency [Formula: see text], which is useful in energy storage capacitor applications. Dielectric studies revealed anomalies around 415–420 K and near the Curie temperature. The latter is attributed to the ferroelectric to paraelectric phase transition. Better dielectric performances were obtained for La-doped samples sintered at 1350°C for 4 h. Grain growth is inhibited with lanthanum (La) incorporation into the BTO lattice. Room temperature semiconducting behavior with positive temperature coefficient of resistivity (PTCR) behavior at [Formula: see text] is attributed to electron compensation mechanism.
The Upper Jurassic–Lower Cretaceous alluvial-fan deposits of the Kalaza Formation (Central Asia): tectonic pulse or increased aridity?
Authors: Jolivet Marc , Bourquin Sylvie , Heilbronn Gloria , Robin Cecile , Barrier Laurie , Dabard Marie-Pierre , Jia Yingying , De Pelsmaeker Elien , Fu Bihong 
Published: September 2015

Abstract
The topographical evolution of tectonic systems, as well as the sedimentation pattern and depositional environments in the associated basins, are controlled by both tectonics and climate. In the region of the Tien Shan (Central Asia), the Jurassic–Lower Cretaceous period was marked by complex, low-intensity tectonic deformation and major climate changes from humid to arid conditions (Jurassic) to semi-arid conditions (Cretaceous). Using the sediment record in the Junggar, Tarim and Fergana basins to describe the tectonic evolution of the Tien Shan area during the Mesozoic thus requires differentiation between the tectonic and climatic influences on sedimentation. The conglomerates of the Upper Jurassic–Lower Cretaceous Kalaza Formation were commonly associated with renewed tectonic activity resulting from the docking of the Lhasa block along the southern margin of Asia. From sedimentology and sequence stratigraphy analyses of several sections in the Junggar, Tarim and Fergana basins, we reassess the main factors controlling the deposition of this formation. We show that, while some tectonic activity persisted throughout the Jurassic–Cretaceous transition, the switch from the sandy deposits of the Upper Jurassic Qigu Formation to the coarse deposits of the Kalaza Formation is largely linked to the development of an arid climate.
Gradient bandwidth allocations
Authors: Jonckheere Matthieu , Shneer Seva 
Published: September 2015

We look at bandwidth-sharing networks where bandwidth allocations are not known to maximize a priori any utility function. Instead, we only require the allocation functions to be 0-homogeneous and concave, which are desirable properties in many situations.
We show that a certain gradient condition is necessary and sufficient for such allocations to solve an optimization problem leading to important corollaries such as deriving the stability set of these 0-homogeneous concave allocation.
Pregnancy Complications and Cardiovascular Disease Death
Authors: Cirillo Piera M. , Cohn Barbara A. 
Published: September 2015

Background—
Few studies have investigated the combination of pregnancy complications that predict risk for cardiovascular disease (CVD) death and how risk changes with age. This report presents a comprehensive investigation of the relation of the occurrence of multiple pregnancy complications to CVD death over 5 decades in a large pregnancy cohort.

Methods and Results—

We examined pregnancy events (1959–1967) and CVD death through 2011 in 14 062 women from the Child Health and Development Studies. CVD death was determined by linkage to California Vital Statistics and National Death Index. Women were a median age of 26 years at enrollment and 66 years in 2011. Preexisting hypertension (hazard ratio, 3.5; 95% confidence interval, 2.4–5.1); glycosuria (hazard ratio, 4.2; confidence interval, 1.3–13.1); late-onset preeclampsia (after week 34, hazard ratio, 2.0; confidence interval, 1.2–3.5); and hemoglobin decline over the second and third trimesters (hazard ratio, 1.7; confidence interval, 1.2–2.7) predicted CVD death. Delivery of a small-for-gestation or preterm infant and early-onset preeclampsia (by week 34) significantly predicted premature CVD death (
P
<0.05 for age dependence). Preterm birth combined with hemorrhage, gestational hypertension, or preexisting hypertension identified women with a 4- to 7-fold increased risk of CVD death. Preeclampsia in combination with preexisting hypertension conferred a significant nearly 6-fold risk in comparison with a 4-fold risk for preexisting hypertension alone.

Conclusions—
We observed combinations of pregnancy complications that predict high risk of death and 2 new risk markers, glycosuria and hemoglobin decline. Obstetricians serve as primary care physicians for many young women and can readily use these complications to identify high-risk women to implement early prevention.
Impact of Contact Force Technology on Atrial Fibrillation Ablation: A Meta‐Analysis
Authors: Shurrab Mohammed , Di Biase Luigi , Briceno David F. , Kaoutskaia Anna , Haj‐Yahia Saleem , Newman David , Lashevsky Ilan , Nakagawa Hiroshi , Crystal Eugene 
Published: September 2015

Background

Catheter–tissue contact is essential for effective lesion formation, thus there is growing usage of contact force (
CF
) technology in atrial fibrillation ablation. We conducted a meta‐analysis to assess the impact of
CF
on clinical outcomes and procedural parameters in comparison to conventional catheter for atrial fibrillation ablation.

Methods and Results

An electronic search was performed using major databases. Outcomes of interest were recurrence rate, major complications, total procedure, and fluoroscopic times. Continuous variables were reported as standardized mean difference; odds ratios were reported for dichotomous variables. Eleven studies (2 randomized controlled studies and 9 cohorts) involving 1428 adult patients were identified.
CF
was deployed in 552 patients. The range of
CF
used was between 2 to 60 gram‐force. The follow‐up period ranged between 10 and 53 weeks. In comparing
CF
and conventional catheter groups, the recurrence rate was lower with
CF
(35.1% versus 45.5%, odds ratio 0.62 [95% CI 0.45–0.86],
P
=0.004). Shorter procedure and fluoroscopic times were achieved with
CF
(procedure time: 156 versus 173 minutes, standardized mean difference −0.85 [95%
CI
−1.48 to −0.21],
P
=0.009; fluoroscopic time: 28 versus 36 minutes, standardized mean difference −0.94 [95%
CI
−1.66; −0.21],
P
=0.01). Major complication rate was lower numerically in the
CF
group but not statistically significant (1.3% versus 1.9%, odds ratio 0.71 [95%
CI
0.29–1.73],
P
=0.45).

Conclusions

The use of
CF
technology results in significant reduction of the atrial fibrillation recurrence rate after atrial fibrillation ablation in comparison to the conventional catheter group.
CF
technology is able to significantly reduce procedure and fluoroscopic times without compromising complication rate.
A new species of Ituglanis Costa &amp; Bockmann, 1993 (Siluriformes: Trichomycteridae) endemic to the Tramandaí–Mampituba ecoregion, southern Brazil
Authors: FERRER JULIANO , DONIN LAURA M. , MALABARBA LUIZ R. 
Published: September 2015

Ituglanis boitata, new species, is described from the rio Tramandaí system and rio Mampituba and Araranguá basins, southern Brazil. This new species is distinguished from congeners with the exception of I. bambui, I. boticario, I. paraguassuensis and I. proops by the supraorbital canal of the cephalic laterosensory system interrupted between nasal and frontal sections and the presence of pore s2 (vs. supraorbital canal uninterrupted and pore s2 absent). Ituglanis boitata differs from these species in osteological characters, measurements and body coloration. Ituglanis boitata presents a noticeable endemism in the Tramandaí–Mampituba freshwater ecoregion, a recognized biogeographic unit for freshwater fishes including other 22 endemic species. A discussion about the intraspecific variation in the cephalic laterosensory system within Trichomycterinae is also provided.
Impacts of Updraft Size and Dimensionality on the Perturbation Pressure and Vertical Velocity in Cumulus Convection. Part I: Simple, Generalized Analytic Solutions
Authors: Morrison Hugh 
Published: September 2015

Abstract
This study investigates relationships between vertical velocity, perturbation pressure, updraft size, and dimensionality for cumulus convection. Generalized theoretical expressions are derived from approximate analytic solutions of the governing momentum and mass continuity equations for both two-dimensional (2D) and axisymmetric quasi-three-dimensional (3D) steady-state updrafts. These expressions relate perturbation pressure and vertical velocity to updraft radius R, height H, and thermal buoyancy. They suggest that the vertical velocity at the level of neutral buoyancy is reduced from perturbation pressure effects by factors of and in 2D and 3D, respectively, where is a nondimensional length, with somewhat different scalings lower in the updraft (α is a parameter equal to the ratio of vertical velocity horizontally averaged across the updraft to that at the updraft center). They also indicate that updrafts are weaker in 2D than 3D, all else being equal, with a difference of up to a factor of 2 in vertical velocity for as a direct result of differences in mass continuity between 2D and axisymmetric 3D flow. Differences between these expressions and other analytic solutions, including those derived from single normal mode Fourier/Fourier–Bessel expansion of the buoyant perturbation pressure Poisson equation, are discussed. Part II of this study compares the theoretical expressions with numerical solutions of the buoyant perturbation pressure Poisson equation for a wide range of thermal buoyancy profiles representing shallow-to-deep moist convection and also with fully dynamical 2D and 3D updraft simulations.
Large-Scale Dynamics of Circulations with Open-Ocean Convection
Authors: Schloesser Fabian 
Published: September 2015

AbstractFormation of the densest water masses in the North Atlantic and its marginal seas involves open-ocean convection. The main goal of this study is to contribute to the general understanding of how such convective regions connect to the large-scale ocean circulation. Specifically, analytic and numerical versions of a variable density layer model are used to explore the processes underlying the circulation in an idealized ocean basin. The models are forced by a surface buoyancy flux, which generates a density maximum in the ocean interior. In response to the forcing, a region forms that is characterized by the closed Rossby wave characteristics and where the eddy–mean transport converges toward the convective site. Outside of that region, characteristics extend from the eastern boundary and a distorted β-plume circulation develops, linking the convection site with the western boundary. The overturning strength in the model can be related to several environment variables and forcings and is constrained by the surface density field, stratification, eddy mixing strength and by Rossby wave dynamics. Solutions forced by an interior ocean density minimum are also considered. Although no convection occurs, the dynamics underlying the circulation are closely related to the case with cooling.
Absorbable Steroid-Impregnated Spacer After Endoscopic Sinus Surgery to Reduce Synechiae Formation
Authors: Xu Jason J. , Busato Gian-Marco , McKnight Carmen , Lee John M. 
Published: September 2015

Objective: Middle meatal synechiae formation after endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) leads to higher rates of revision surgery. We aimed to determine if there are different rates of postoperative synechiae following ESS for CRS between patients who received a nonabsorbable spacer (NAS) placed in the ethmoid cavity versus patients who had a steroid-impregnated absorbable spacer (AS) placed at the middle meatal entry. Methods: We conducted a retrospective cohort study of patients who underwent ESS for CRS at a single tertiary referral center from October 2009 to October 2013. We collected data on synechiae formation between the middle turbinate and lateral nasal wall within 1 month of surgery and postoperative epistaxis. Results: One hundred forty-six patients with 252 nasal cavities (52.0%) received steroid-impregnated AS, and 128 patients with 233 nasal cavities (48.0%) received NAS. Synechiae formation occurred in 2.0% of cavities with AS and 5.6% of cavities with NAS, but this difference was not statistically significant (OR = 0.34, P = .052). One patient in each cohort had significant postoperative epistaxis requiring additional nasal packing ( P > .99). Conclusion: Steroid-impregnated absorbable spacers had statistically insignificant reduction in postoperative synechiae formation when compared to nonabsorbable spacers. Low rates of postoperative epistaxis were observed regardless of the type of spacer used.
Diluted thrombin time reliably measures low to intermediate plasma dabigatran concentrations
Authors: Božič-Mijovski Mojca , Malmström Rickard E , Malovrh Petra , Antovic Jovan P , Vene Nina , Šinigoj Petra , Mavri Alenka 
Published: September 2015

Background Direct oral anticoagulant dabigatran was first introduced as a fixed-dose drug without routine coagulation monitoring, but current recommendations suggest that diluted thrombin time can be used to estimate plasma drug level. The aim of this study was to assess a diluted thrombin time assay based on the same thrombin reagent already used for traditional thrombin time measurements that reliably measure low to intermediate plasma dabigatran levels. Methods We included 44 patients with atrial fibrillation who started treatment with dabigatran 150 mg (23 patients) or 110 mg (21 patients) twice a day. Blood samples were collected at baseline (no dabigatran) and 2–4 weeks after the beginning of dabigatran therapy at trough and at peak. Plasma dabigatran levels were measured with diluted thrombin time and compared to liquid chromatography with tandem mass spectrometry as the reference method. The performance of the diluted thrombin time was compared to Hemoclot® Thrombin Inhibitor and Ecarin Chromogenic Assay. Results In ex vivo plasma samples, diluted thrombin time highly correlated with the liquid chromatography with tandem mass spectrometry (Pearson’s R = 0.9799). In the low to intermediate range (dabigatran concentration ≤ 100  µg/L) diluted thrombin time correlated significantly more closely to the liquid chromatography with tandem mass spectrometry (R = 0.964) than Hemoclot® Thrombin Inhibitor (R = 0.935, p = 0.05) or Ecarin Chromogenic Assay (R = 0.915, p < 0.01). It was also the only functional assay without any significant bias in the low to intermediate range. Both trough and peak diluted thrombin time values were similar to liquid chromatography with tandem mass spectrometry. Conclusion We conclude that the diluted thrombin time assay presented in this study reliably detects dabigatran and that it is superior to the Hemoclot® Thrombin Inhibitor assay in the low to intermediate range.
Non-invasive vagus nerve stimulation for PREVention and Acute treatment of chronic cluster headache (PREVA): A randomised controlled study
Authors: Gaul Charly , Diener Hans-Christoph , Silver Nicholas , Magis Delphine , Reuter Uwe , Andersson Annelie , Liebler Eric J , Straube Andreas ,   on behalf of the PREVA Study Group
Published: September 2015

Background Chronic cluster headache (CH) is a debilitating disorder for which few well-controlled studies demonstrate effectiveness of available therapies. Non-invasive vagus nerve stimulation (nVNS) was examined as adjunctive prophylactic treatment of chronic CH. Methods PREVA was a prospective, open-label, randomised study that compared adjunctive prophylactic nVNS ( n = 48) with standard of care (SoC) alone (control ( n = 49)). A two-week baseline phase was followed by a four-week randomised phase (SoC plus nVNS vs control) and a four-week extension phase (SoC plus nVNS). The primary end point was the reduction in the mean number of CH attacks per week. Response rate, abortive medication use and safety/tolerability were also assessed. Results During the randomised phase, individuals in the intent-to-treat population treated with SoC plus nVNS ( n = 45) had a significantly greater reduction in the number of attacks per week vs controls ( n = 48) (−5.9 vs −2.1, respectively) for a mean therapeutic gain of 3.9 fewer attacks per week (95% CI: 0.5, 7.2; p = 0.02). Higher ≥50% response rates were also observed with SoC plus nVNS (40% (18/45)) vs controls (8.3% (4/48); p < 0.001). No serious treatment-related adverse events occurred. Conclusion Adjunctive prophylactic nVNS is a well-tolerated novel treatment for chronic CH, offering clinical benefits beyond those with SoC.