bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instruire en dialoguant : de la poétique au politique
Authors: Barel-Moisan Claire 
Published: July 2024

Si le dialogue constitue une forme ancienne qui, hors du champ romanesque, a longtemps été mise au service de la démarche philosophique et de l’exposé de thèses scientifiques ou politiques, l’usage spécifique du dialogue instructif au sein du roman a coïncidé au xix e siècle avec une vision politique de l’éducation populaire selon laquelle la connaissance descend du savant à l’ignorant. Pour éviter que l’échange dévie vers le discours pontifiant, acclimater le savoir au roman suppose donc de doter le dialogue didactique de fonctions narratives. Mais loin d’une véritable polyphonie où le savoir émergerait de la confrontation des voix, le dialogue instructif met en œuvre une communication strictement orientée. Rares sont les exemples de « romans du maître ignorant ». Si le dialogue instructif tend à s’effacer du roman après les années 1880, c’est ainsi qu’il s’identifie à un projet positiviste désormais largement contesté.
Du journal à la revue : étude comparée du discours sur le style au XIX e siècle
Authors: Kaës Emmanuelle , Vidotto Ilaria 
Published: July 2024

Cette étude se propose de comparer les discours sur le style dans deux corpus distincts de périodiques : la critique littéraire dans la grande presse quotidienne d’une part, la critique littéraire dans la revue, lieu de publication prestigieux et gage de légitimité littéraire, d’autre part. Le premier corpus est constitué d’articles de la presse quotidienne, tous formats confondus, et d’orientation idéologique variée. Le second rassemble des articles tirés de revues de culture générale comme la Revue des Deux Mondes, la Revue politique et littéraire , ou de publications spécifiquement littéraires et artistiques comme le Mercure de France . Extraites au moyen du logiciel Anatext, les données sont explorées à partir de trois moments-clés, 1840, 1866 et les années 1880-1890. Par le « magistère » culturel qu’elle exerce, la critique des revues offre un espace plus ample au développement d’une réflexion sur le style, tandis que la grande presse tend à solliciter les qualificatifs préfabriqués de la vulgate rhétorique. Le discours médiatique sur le style n’intègre que progressivement, à partir de la seconde moitié du siècle, les valeurs de l’expressivité individuelle et de l’originalité – cette intégration donnant lieu à une dissension entre la modélisation rhétorique des styles et la conception nouvelle du style comme signature individuelle, conception qui intègre les acquis du romantisme.
Urinary Tract Aspergillosis in a Child with Pelviureteric Junction Obstruction
Authors: Raj Nikhil , Saha Ankita , Singh Riddhi , Rautela Apurva , Singh Vikramjeet , Das Anupam , Sen Manodeep , Agarwal Jyotsna 
Published: July 2024

Abstract

Aspergillus spp. are fungi which are mostly nonpathogenic, but some species such as Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger can cause aspergillosis in humans. Aspergillosis can manifest as pulmonary or extrapulmonary infections, with respiratory involvement being common but infections in other body parts being rare. Urinary aspergillosis, an uncommon manifestation of Aspergillus infection, presents unique challenges in diagnosis and management due to its rarity and varied clinical presentations. It is seen in immunocompromised individuals, patients with underlying structural urinary tract abnormalities, or those undergoing invasive procedures. Here, we present a case of an 8-month-old child who presented with intermittent fever and increased urination since birth. The child underwent bilateral open pyeloplasty with double-J (DJ) stenting. A month later, the child returned with anuria, fever, and abdominal mass, leading to infected DJ stent removal and bilateral percutaneous nephrostomy. Despite antibiotic treatment, fever persisted. A fungal culture was done which showed growth of A. flavus. Liposomal amphotericin B was started for the patient after which he became afebrile, and all the fungal cultures done, thereafter, were negative. Urinary tract aspergillosis is rare, particularly among individuals with a strong immune system. Persistence of urinary tract symptoms despite antibiotic and medical therapy may raise the possibility of fungal infection such as urinary tract aspergillosis.
Cellular Pleomorphic Adenoma of Minor Salivary Glands with Collagenous Crystalloids: A Peculiar Finding
Authors: Sharma Sudha , Singh Atul , Chandran V. Anish 
Published: July 2024

Abstract
Pleomorphic adenoma (PA) is a benign salivary tumor uncommonly seen in minor salivary glands. Collagenous crystalloids are an uncommon finding and may pose a diagnostic dilemma in cellular PA. We present a case of myoepithelial cell-rich PA of hard palate with paucity of chondromyxoid stroma and characteristic collagenous crystalloids.
Desmoid Type of Fibromatosis of Ureter: A Rare Case
Authors: Mishra Sanjay Kumar , Trisal Monal , Mishra Jyoti 
Published: July 2024

Abstract
This study presents a rare case of desmoid-type fibromatosis (DTF) in the ureter of a young adult, highlighting its unusual occurrence within the urinary tract. The patient experienced right flank pain, leading to the discovery of gross hydroureteronephrosis with a suspicious distal ureteric mass. Surgical intervention revealed a well-defined tumor displaying characteristic histological features of DTF. Immunohistochemistry confirmed the diagnosis. Despite the absence of nuclear β-catenin expression, the patient underwent wide local excision. This case highlights the need for individualized treatment plans for DTF and emphasizes its consideration in cases of obstructive uropathy with atypical mass presentations.
Parotid Gland Metastasis of Conjunctival Squamous Cell Carcinoma: A Case Report of a Rare Phenomenon
Authors: Vias Poorva , Saklani Ashish , Thakur Anantika , Sankhyan Era 
Published: July 2024

Abstract
Squamous cell carcinoma (SCC) of the conjunctiva is rare. It is commonly associated with ultraviolet ray exposure, viral infections, and conjunctivitis. Its management includes surgical excision with adjuvant treatment. Surgery alone leads to a high risk of recurrence even in early stages. Local recurrence is most common, and chemotherapy is preferred over resurgery in such cases. Lymphatic and distant metastases are seen in advanced cases. Here, we present an elderly female with early-stage SCC of the conjunctiva who underwent surgery alone, defaulted, and presented with parotid gland metastasis without any evidence of residual disease in the eye. The various lines of management have been discussed here.
Peripheral Ossifying Fibroma in a 5-year-old Female Patient: A Rare Case Report
Authors: Siddiqui Maryam , Juneja Akanksha , Sultan Amina , Popli Deepika Bablani 
Published: July 2024

Abstract
Peripheral ossifying fibroma (POF) represents a rare entity among the frequently encountered solitary gingival growths. It is a reactive benign lesion of connective tissue whose pathogenesis is idiopathic, but authors believe that inflammatory hyperplasia originating in the superficial periodontal ligament can cause POF occurrence. Indistinguishable clinical features of soft-tissue lesions make the diagnosis strenuous for clinicians. However, we can achieve a definitive diagnosis with the help of histological findings. The favorable therapy of POF is surgical excision of the lesion along with the underlying periosteum after eliminating all possible local contributing factors to reduce its recurrence. This article presents a case of POF in a 5-year-old Indian girl who reported painless swelling in the area of mandibular anterior and also discusses its clinical presentation, radiographic findings, histological features, diagnosis, and satisfactory clinical management.
RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway
Authors: Xu Lu , Xie Zhi-Hao , Li Jun , Tao Shi , Ren Fang-Li , Wang Yin-Yin , Chang Zhi-Jie , Hao Xin-Bao 
Published: July 2024

Objective:
To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma (DLBCL) and its potential as a therapeutic target.

Methods:
This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival analysis. In vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and apoptosis.

Results:
RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor prognosis. In vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling pathway.

Conclusions:
RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular proliferation. Targeting RPRD1B may offer a novel therapeutic strategy for DLBCL, suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.
Persicaria lanigera (Polygonaceae) leaf extract exhibits antiulcerogenic and antiproliferative activities against acetic acid-induced ulcerative colitis and cotton pellet-induced granuloma tissue in rats
Authors: Antwi-Adjei Meshack , Obese Ernest , Adakudugu Emmanuel Awintiig , Aboagye Benjamin , Anokwah Daniel , Karikari Akua Afriyie , Antwi-Adjei Roberta , Ameyaw Elvis Ofori 
Published: July 2024

Objective:
To assess the effect of leaf extract of Persicaria lanigera on cotton pellet-induced granuloma tissue formation and acetic acid-induced ulcerative colitis.

Methods:
Rats were randomly divided into six groups: normal control, negative control, positive control (dexamethasone or sulfasalazine) as well as Persicaria lanigera (100-600 mg/kg)-treated groups. The effects of the extracts on body weight, antioxidant, and hematological parameters, as well as mast cell proliferation, were assessed. In addition, a histological evaluation was conducted.

Results:

Persicaria lanigera extract significantly decreased the mean exudate amount and suppressed granuloma tissue formation in a concentration-dependent manner in rats (P<0.05). Additionally, the extract significantly increased body weight, improved hematological profile, reduced the disease activity index score and malondialdehyde level, as well as enhanced catalase and superoxide dismutase activities (P<0.05). Histological evaluation showed Persicaria lanigera extract alleviated acetic acid-induced colonic damages, as evidenced by decreased cell necrosis, edema, and inflammatory cell infiltration.

Conclusions:

Persicaria lanigera extract possesses antiproliferative, antioxidative, and anti-colitis activities. However, its underlying mechanisms of action need further investigation.
Investigating the Relationship between Maximum Aerobic Capacity and Cognitive Ability and Employees’ Workability in a Dairy Factory
Authors: Faridan Mohammad , Mahdavi Neda , Tajik Leila , Mohammadi Rasool , Alizadeh Faezeh , Abdikia Faezeh 
Published: July 2024

Abstract

Aim:
Considering the importance and necessity of physical and mental fitness of the employees with their job demands, this study aimed to estimate the levels of aerobic capacity among the workers and determine the factors that might affect these levels. The relationship between the aerobic capacity levels and the values of workers’ cognitive function and workability was also investigated.

Materials and Methods:
Sixty healthy male employees from a dairy factory were recruited using a random sampling method. The study design consisted of the completion of checklists containing personal data, anthropometric measurements, and evaluation of job ability, maximum aerobic capacity along with the cognitive ability of the participants using the Workability Index (WAI) standard questionnaire, Queen’s College step test, and psychomotor vigilance test (PVT), respectively.

Results:
The mean values of VO2 max, reaction time (RT), and WAI of workers were 45.54 ± 6.13 mL/kg/min, 337.82 ± 29.93 ms, and 42.76 ± 5.02, respectively. Based on the Pearson correlation test, a weak statically significant correlation was observed between PVT and VO2 max (r = 0.3, P = 0.02) as well as PVT and physical work capacity (r = 0.263, P = 0.04). The findings of this study showed that there was a significant relationship between height, weight, body mass index, RT, and error percentage with maximal aerobic capacity (VO2 max).

Conclusion:
According to the physiological criteria, the employees’ capabilities and job requirements are not in balance; particularly for those working in laboratory, office, or service departments. Therefore, using standardized recruitment tests, providing sports facilities and developing integrated indicators are a principal element of establishing an ergonomic balance in this workplace.
A Study Assessing the Correlation of Atherogenic Index of Plasma with Severity of Coronary Artery Disease by Modified Gensini Score in Postmenopausal Women
Authors: Parvathareddy Krishna Mala Konda Reddy , Pabba Anish , Nagula Praveen , Motkar Ankith Reddy , Suneetha K , Ravi Srinivas , Syed Imamuddin 
Published: July 2024

ABSTRACT

Introduction:
The latest area of interest in lipids is small dense low-density lipoprotein cholesterol (sdLDL-C). They are highly atherogenic. There is no effective way of estimating them convetionally. Atherogenic index of plasma (AIP) reflects the level of sdLDL-C. The postmenopausal women have increased likelihood for coronary artery disease (CAD). In this study, the correlation between AIP and severity of CAD in postmenopausal women was assessed.

Materials and Methods:
A total of 448 postmenopausal women with chest pain were screened, of which 252 had a provisional diagnosis of CAD. Of them, 148 patients satisfying inclusion criteria were enrolled. Routine investigations, electrocardiogram, echocardiography, and coronary angiogram (CAG) were performed. Modified Gensini score (mGS) was used for severity of CAD. Chi-square test and Spearman correlation were used to analyze the correlation.

Results:
The mean age was 57 ± 8.3 years. The most common presentation was STEMI (32.4%), followed by unstable angina (28.4%). Patients already on statin therapy were 26.4%. Hypertension (HTN) was the most common risk factor (38.5%), followed by diabetes with HTN (23%). The mean AIP and mGS score were 0.23 ± 0.16 and 99.66 ± 65.61, respectively. Higher AIP values were seen in patients with higher mGS. Patients on statins and with normal lipid parameters showed higher mGS and AIP. There was a positive correlation of AIP with diabetes, HTN, Vitamin-D deficiency, C-reactive protein, body mass index, waist-circumference, waist-hip ratio, and waist-height ratio.

Conclusion:
AIP is a novel indicator and a strong marker for predicting the severity of CAD in postmenopausal women. In postmenopausal women with recurrent CAD and on statin therapy previously, AIP levels were high, implying that they need further management.
Sports activities as an integrative approach to overcome stigma associated with HIV/AIDS
Authors: Goyal Atul Kumar , Saini Jyoti 
Published: July 2024

Abstract

Background:
Traditional methods of HIV/AIDS awareness are failed to achieve significant participation from the community because young adults hesitate to participate in such activities due to the stigma associated with the disease.

Objective:
We proposed that if HIV/AIDS awareness programs are conducted integratively with sports activities, it may result in significant participation from the community, which in turn helps in overcoming the stigma associated with the disease.

Methods:
We conducted a literature review of various studies highlighting the role of sports activities in spreading HIV/AIDS awareness. We also conducted a pilot study by taking bicycle run activity to analyze its role in spreading HIV/AIDS awareness.

Results:
We found only five studies in which sports activities have been used to overcome stigma associated with HIV/AIDS. Football or soccer is the primary sports activity adopted to overcome HIV/AIDS stigma among school and college students. In our pilot trial, when we used the bicycle run as a means to overcome HIV/AIDS stigma, significant participation from the community was achieved.

Conclusions:
Sports activities can convey the message of HIV/AIDS awareness in a much more effective way compared to traditional methods. We recommended that the government should integrate HIV/AIDS awareness programs with sports activities to overcome stigma associated with the disease.
Cystica indeterminata – A novel intriguing pelvic pathology in a 9-year-old girl
Authors: Pal Kamalesh , El Bahtimi Reem , Pal Aniket , Pal Ankita 
Published: July 2024

Abstract
Intra-abdominal cystic lesions are commonly associated with visceral locations such as renal, hepatic, pancreatic, ovarian/adnexal, and mesenteric. Rarely, nonvisceral locations such as retroperitoneum, free intra-peritoneum, prevertebral space, and pelvis harbor cystic lesions. In almost all these lesions, radiology, histopathology, immunostaining, and serology markers are able to assign a definite origin and pathogenesis. Very rarely a clear diagnosis is not possible, and these lesions have been designated as “indeterminate” lesions. We report the first case of “cystica indeterminata” with completely obscure origin and histopathogenesis in a 9-year-old female child. Clinical, radiological, seromarkers, histopathology, related differentials, and pathogenesis have been discussed. We hypothesize that aborted organogenesis or acquired degenerative/involutory changes may lead to such indeterminate lesions.
Rheumatic diseases in the elderly: Challenges and management
Authors: Agarwal Avarna , Padhan Prasanta 
Published: July 2024

Abstract
The elderly demographic is seeing a gradual rise as a proportion of the overall global population, whilst also experiencing high rates of musculoskeletal issues, requiring specialized care. The management of rheumatic diseases in the elderly presents unique challenges due to the complex interplay among physiological changes, cognitive decline, and altered immune responses. Such conditions can be categorized into those progressing from earlier life stages (such as rheumatoid arthritis, systemic lupus erythematosus, spondyloarthritis, and gout) and those predominantly emerging in old age (such as polymyalgia rheumatica, giant cell arteritis, osteoarthritis, crystal arthropathies, and osteoporosis), each with distinct characteristics and management needs. These diseases often present atypically with nonspecific symptoms and altered serological markers, complicating diagnosis and management due to increased toxicity risks and comorbidities. Comprehensive, multidisciplinary care that includes cardiovascular health monitoring, bone density maintenance, gastrointestinal tolerance management, infection prevention, and mental health support are essential to improve outcomes and quality of life for elderly patients with rheumatic diseases.
Effect of Vitamin C on Blood Glucose Levels, Glycosylated Hemoglobin, and Serum Lipid Profile in Patients with Type 2 Diabetes Mellitus: A Prospective Study
Authors: Mukadam Fehmi M. , Gawali Ujwala P. , Pore Shraddha M. 
Published: July 2024

Abstract

Background:
Vitamin C reduces oxidative stress as well as prevents nonenzymatic glycosylation of proteins because of its structural similarity to glucose. This prospective study was conducted to investigate the impact of vitamin C supplementation on glycemic control and serum lipid profile in newly diagnosed patients with type 2 diabetes mellitus (T2DM).

Materials and Methods:
Adult patients attending the outpatient department of a tertiary care hospital, diagnosed with T2DM within the last 3 months, with fasting blood glucose (FBG) levels exceeding 126 mg/dL, were randomly assigned to either control group (n = 98) or study group (n = 102). The study group received oral vitamin C (1 g/day) in addition to metformin 500 mg twice daily, while the control group received metformin 500 mg twice daily alone. Baseline characteristics, including age, gender, and comorbidities, were recorded. The parameters FBG, postprandial blood glucose (PPBG), glycosylated hemoglobin (HbA1c), and serum lipid profile were measured at baseline and at the 12th week.

Results:
Both the control and study groups experienced significant reductions in FBG, PPBG, and HbA1c levels after 12 weeks. However, the study group exhibited greater improvements, with FBG decreasing by 22.42 ± 2.7 mg/dL (P < 0.05), PPBG decreasing by 33.25 ± 4.9 mg/dL (P < 0.05), and HbA1c decreasing by 1.33 ± 0.3 g% (P < 0.05). Additionally, both groups demonstrated significant improvements in serum lipid profile parameters, with the study group showing more significant improvements in high-density lipoprotein, low-density lipoprotein, triglycerides, and total cholesterol levels compared to the control group.

Conclusion:
Vitamin C supplementation as an adjuvant therapy with metformin for 12 weeks produces beneficial effects in T2DM patients, including improved glycemic control and significant improvement in the lipid profile.
Diabetes and Stroke—A Focused Review
Authors: Menon Bindu , Syed Rizwana , Yadav Praveen Kumar , Menon Medha 
Published: July 2024

Abstract
Globally, diabetes mellitus (DM) and stroke are two common chronic illnesses that have a substantial impact on rates of morbidity and mortality. There is significant evidence linking diabetes to an increased risk of stroke in terms of incidence, severity, and mortality. This extensive review looks at shared risk factors, underlying pathophysiological mechanisms, epidemiological trends, and evidence-based therapy approaches to give a thorough analysis of the causal relationship between diabetes mellitus and stroke. Studies using epidemiological data regularly show that people with diabetes have a higher incidence of stroke than people without the disease. Furthermore, diabetes is linked to a less favorable outcome following a stroke, as well as an elevated chance of stroke recurrence. Determining the pathophysiological pathways that connect diabetes and stroke is essential to understanding their relationship. Key pathophysiological processes associated with these disorders include endothelial dysfunction, inflammation, oxidative stress, hyperglycemia, and dyslipidemia. Due to microvascular complications, these mechanisms raise the risk of hemorrhagic stroke and predispose diabetics to an increased risk of ischemic stroke by creating a prothrombotic and atherosclerotic milieu. Diabetes and stroke are linked due to shared risk factors like smoking, obesity, dyslipidemia, hypertension, and poor glycemic control. Lifestyle changes, blood pressure control, lipid-lowering therapy, antiplatelet medicines, and a nutritious diet are essential for stroke risk reduction. Reducing the risk of stroke in people with diabetes requires the implementation of management techniques that focus on both diabetes control and stroke prevention. Optimizing results and lowering the frequency of stroke-related complications in diabetics requires multidisciplinary care. The intricate interactions between diabetes mellitus and stroke are highlighted in this review’s conclusion, which also highlights the value of patient education, risk factor treatment, the effect of antidiabetic therapy on stroke, and integrated care in lowering the incidence of stroke in people with diabetes.