bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Comparison of Binding Pocket of Berberine Protein Crystals
Authors: Ma Jin-Rong , Huang Qiu-Rong , Man Ruo-Jun , Zhao Linguo , Li Dong-Dong 
Published: July 2024

Introduction:
Berberine is an important isoquinoline alkaloid that has various pharmacological
properties. The comparison of the binding pocket similarity of berberine is regarded as the
starting point for deciphering various activities. Eight berberine protein crystals were clustered and
studied by molecular dynamics (MD) simulations to investigate common features of berberine binding
pockets.

Methods:
Root Mean Square Deviation (RMSD) results showed that berberine was able to bind to
each protein in a stable manner. Residue analysis showed that the stability of residue composition of
different protein pockets varied. This is also consistent with the results of the pocket similarity analysis:
PS-score curves of most proteins fluctuated to varying degrees. The binding pocket of 3BTI in
homogeneous protein analysis exhibited high stability (PS-scoremean = 0.703 and PS-scoremin =
0.5664). Pocket similarity analysis between two heterologous proteins showed that most of PS-score
values were in the interval of 0.3-0.35, and PS-score values of 3D6Y were relatively high when
compared with the other three proteins.

Results:
Pocket residue matching analysis showed that GLU145/VAL147/ILE182/TYR229/GLU253
in 3D6Y can be matched structurally to the corresponding residues in 1JUM, 2QVD, and 5Y0V,
respectively, which can be considered as an important pocket feature for the berberine binding. Nevertheless,
the obtained matched residues are limited to the category of pocket structural similarity.

Conclusion:
This was the first study in which dynamic comparison of berberine binding pockets
were used to discover pocket patterns. These results were of great significance for the polypharmacological
study, the identification of potential off-targets, and the repurposing of berberine.
Design of New Aromatic Tertiary Amine-based as Butyrylcholinesterase Inhibitors Relying on Molecular Docking, ADME-Tox and Molecular Dynamics
Authors: Qara Abdelhamid , Ouabane Mohamed , Sekkate Chakib , Chtita Samir , Lakhlifi Tahar , Bouachrine Mohammed 
Published: July 2024

Introduction:
Butyrylcholinesterase (BChE) plays a pivotal role in the progression of
Alzheimer's disease. Empirical research demonstrated a fundamental alteration in the role of
BChE concerning the reduction of cholinergic neurotransmission within the brains of individuals
at advanced stages of Alzheimer's.

Method:
This study focuses on developing potent inhibitors for Butyrylcholinesterase (BChE) in
the context of Alzheimer's disease (AD) treatment. Building upon previous research, a series of 44
aromatic tertiary amine-based compounds was investigated. Starting with ADME-Tox studies, the
pharmacokinetic and pharmacodynamic properties of the compounds were analyzed to select
promising candidates for BChE inhibition, which is a crucial factor in AD pathology.

Results:
Molecular docking analyses identified compound M18 as the most promising candidate,
and further compounds (X9 and X10) were proposed based on M18's chemical structure. These
compounds displayed superior properties in terms of binding energies and hydrogen bonds in comparison
to M18.

Conclusion:
The Molecular Dynamics (MD) simulations, which are over a 500 ns timeframe, confirmed
the conformational stability of compounds X9 and X10, compared to M18. Overall, the
stated results suggest that the proposed compounds, including X9 and X10 specifically, have a significant
potential as candidates for BChE inhibition. This presents a promising avenue for therapeutic
intervention in Alzheimer's disease.
Legal regime of personal data of persons participating in civil proceedings
Authors: Elizarova M. Y. 
Published: July 2024

Relevance.Unlike personal data of a person, personal data of participants in civil proceedings are posted without exception in the texts of decisions on the websites of courts, voiced in video broadcasts, and published in the public domain by search aggregator sites. The article analyzes the concept and content of the legal regime of personal data of persons participating in civil proceedings in relation to the problem of their protection. The legislation on personal data and on ensuring access to information on the activities of courts in the Russian Federation are being studied, establishing the legal regime of personal data of persons participating in civil proceedings in relation to the problem of their protection.The purposeof the study is to deepen scientific knowledge about the essence of the legal regime of personal data of participants in civil proceedings, to develop theoretical concepts and legislative proposals to increase the effectiveness of their protection.Objectives:analyze the legislation governing the legal regime of personal data of persons participating in civil proceedings, identify legal means to ensure their protection, and identify legislative gaps that impede their proper protection.Methodology.The research methodology is represented by general scientific (dialectical, analysis and synthesis of deduction, induction) and private scientific methods (formal-legal, formal-logical, system-analytical).The resultsfound expression in the formulated concept of the legal regime of personal data of participants in civil proceedings, identifying its correlation with the legal regime of personal data of individuals, as well as in proposals for improving the current norms of the Code of Civil Procedure of the Russian Federation, establishing the rules for conducting video broadcasts of court hearings, to protect personal data of the considered category of citizens.Conclusion.The legal regime of personal data of participants in civil proceedings is a procedure for regulating public relations, expressed in a set of legal means aimed at ensuring, in the interests of the whole society, the availability of information about judicial activities, and the protection of personal data of persons participating in civil proceedings. The legal regime of personal data of participants in civil proceedings correlates with the legal regime of personal data of individuals as private and general, and therefore is special in type.
Componentes de la misión en las facultades de contabilidad y administración de universidades públicas
Authors: Hernández Vela Hortensia , Medina Jiménez Armando , Reza Luna Jesús Job 
Published: July 2024

Las universidades públicas estatales de México poseen una misión explícita, y la gran mayoría de las escuelas de contabilidad o administración, generalmente agrupadas en la misma facultad, también cuentan con su propia misión, la cual suele relacionarse con un marco de referencia para orientar las decisiones prioritarias que se toman dentro de las instituciones. Por tal motivo, el objetivo de esta investigación es desarrollar un estudio sistemático para analizar las declaraciones de misiones definidas por las propias universidades. Para ello, se ha formulado la siguiente pregunta de investigación: ¿cuáles son los componentes de los enunciados de las misiones de las escuelas de negocios de las universidades públicas en México? Estos componentes y/o enunciados se han identificado por medio de un análisis de contenido, el cual permitió detectar cuatro categorías interrelacionadas: principios institucionales, relacionados con la identidad, el contexto, los atributos y los valores institucionales; propósito, vinculado con los fines que se persiguen a través del desarrollo expresado en aspectos que las instituciones consideran importantes; formación, asociada con el perfil profesional, y proceso, el cual tiene que ver con generación, aplicación y difusión del conocimiento, donde destaca el isomorfismo que presentan los enunciados de estas misiones.
Unveiling Heavy Metal Pollution in Soils and Rice Crops (Oryza sativa L.) Cultivation
Authors: Danapriatna Nana , Dede Moh. , Widiawaty Millary Agung , Puspitaningrum Hardini , Lutfiadi Ridwan 
Published: July 2024

The landscape changes through the increasing built-up areas (settlements and industrial) have a potential impact on reducing the quality of agricultural land. Waste from anthropogenic activities (industrial and domestic) is the main source of heavy metals that can affect rice production in the fields. This study examines the quality changes of paddy fields (Oryza sativa L.) polluted by wastewater in Muara Bakti Village, Bekasi Regency. Wastewater's impact on paddy fields is known through heavy metal contamination analysis in soil and rice plants. Chemical analysis of soil, water and plants was completed by the Balai Penelitian Tanaman Sayuran (Balitsa) Laboratory, West Bandung. The results showed that heavy metal levels such as lead (Pb) and cadmium (Cd) in the paddy soil samples were above the threshold in soil, respectively more than 25 mg/l and 0.01 mg/l. In contrast, the rice plant samples, it was identified as containing heavy metals such as Cd and chromium (Cr). Pb content was not detected in the rice plants. Soil in Muara Bakti Village contained optimal nutrients that are still suitable for agriculture. However, heavy metal content detected in soil samples and rice plants requires special handling to prevent endangering the agroecosystem and human health. Keywords: Agroecosystem, Heavy metals, Paddy fields, Soil pollution, Waste
Why Do So Few Preliminary Questions Come From Czechia?
Authors: Kunertová Tereza 
Published: July 2024

Abstract
Although a substantial part of the body of laws of an EU Member State is founded upon European Union law and norms, the number of preliminary questions emanating from courts in the Czech Republic appears to be disproportionately low compared to other similar EU Member States. The aim of this article is to analyse and outline possible reasons for the lack of preliminary questions coming from the Czech Republic. In her analysis, the author identifies three possible factors underpinning the issue. These factors include attitudes towards the EU and a general lack of understanding of the relevance of EU laws and norms; the role of preliminary rulings; and the perception and recognition of courts. An integral part of this analysis is a critical commentary on the shifts in how courts and tribunals are perceived within the meaning of Art. 267 TFEU. Lastly, the author offers guidance to fellow legal professionals and academics for interpreting EU norms.
PENGARUH LATIHAN DENGAN POLA BOOMERANG TERHADAP PENINGKATAN KETERAMPILAN DRIBBLING DALAM PERMAINAN SEPAKBOLA
Authors: Ramdani Dicky Wahyu , Suhendra Dede Iman , Kustiawan Hendra 
Published: July 2024

Pengaruh Latihan dengan Pola Boomerang terhadap Peningkatan Keterampilan Dribbling dalam Permainan Sepakbola yang dilaksanakan di MTs Tonjongsari menunjukkan pada kondisi yang belum terlaksana dengan baik. Hal ini terjadi karena masih belum tersampaikannya dengan baik kepada siswa terkait dengan metode dribbling run sehingga dalam penerapannya banyak mengalami kendala yang meliputi belum tersampaikannya model boomerang run. Sehingga dengan adanya penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh latihan dengan pola boomerang terhadap peningkatan keterampilan dribbling dalam permainan sepakbola pada siswa ekstrakulikuler di Mts Tonjongsari. Penulis menggunakan metode eksperimen yaitu pre-experimental designs (nondesigns) dengan desain penelitian menggunakan desain one-group pretest-postest design. Adapun untuk temuan berdasarkan hasil penghitungan dapat diambil kesimpulan bahwa latihan dengan pola boomerang tidak meningkatkan keterampilan dribbling dalam permainan sepak bola siswa Mts Tonjongsari secara signifikan. Oleh karena itu diharapkan dengan terus menggunakan media pembelajaran yang kreatif dapat dipergunakan khususnya bagi para pemula dalam upaya meningkatkan keterampilan teknik dasar terutama dribbling permainan sepakbola. Kata Kunci: Latihan, Model Boomerang, Keterampilan, Dribbling, dan Sepakbola.
PEMANFAATAN SITUS CANDI RONGGENG SEBAGAI SUMBER BELAJAR SEJARAH DENGAN MEDIA MORPH TRANSITION POWERPOINT UNTUK SISWA KELAS X IPS II MA FATHURRAHMAN
Authors: Fauzan Ahmad , Wijayanti Yeni , Nurholis Egi 
Published: July 2024

Penelitian ini bertujuan untuk mendeskripsikan situs Candi Ronggeng sebagai sumber belajar Sejarah dengan media morph transition powerpoint untuk siswa kelas X IPS II MA Fathurrahman. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif dengan teknik pengumpulan data observasi, wawancara dan dokumentasi/kepustakaan. Hasil penelitian menunjukkan bahwa proses pembelajaran Sejarah di MA Fathurrahman menggunakan metode ceramah. Sumber belajar yang dipakai oleh guru hanya dari buku paket yang disediakan sekolah. Pemanfaatan situs Candi Ronggeng sebagai sumber belajar Sejarah dilakukan melalui media powerpoint dengan fitur morph transition. Kendala yang dihadapi dalam pemanfaatan situs Candi Ronggeng sebagai sumber belajar adalah keterbatasan materi mengenai situs candi tersebut, keberadaan situs yang tertimbun tanah.Kata Kunci: Situs Candi Ronggeng, Sumber Belajar, Pembelajaran Sejarah, Media Morph Transition Powerppoint
PENGARUH MODEL PROBLEM BASED LEARNING TERHADAP KEMAMPUAN BERPIKIR KREATIF SISWA SMA PLUS AL-FALAH TASIKMALAYA
Authors: Ardiansyah Ari , Sopyan Taupik , Yulisma Lia 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui Pengaruh Kemampuan Berpikir Kreatif Siswa SMA Plus Al-Falah Tasikmalaya setelah diterapkannya Model Problem Based Learning. Penelitian ini merupakan penelitian kuantitatif dengan metode yang digunakan adalah quasi Experimental dan desain penelitiannya menggunakan One Group Pretest-Posttest yang memberikan satu perlakuan terhadap subjek yang sama berupa penggunaan Model Problem Based Learning . Pengambilan sampel menggunakan teknik Sampel Total atau sensus yaitu siswa kelas X IPS 1 dengan jumlah 32 Siswa sebagai kelas eksperimen. Instrumen yang digunakan berupa pretest-posttest untuk mengetahui kemampuan berpikir kreatif siswa. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh yang signifikan dari penggunaan model problem based learning Terhadap kemampuan berpikir kreatif siswa SMA Plus Al-Falah Tasikmalaya.Kata kunci: Berpikir Kreatif, Sampel Total, Problem Based Learning
PENGARUH KEBIJAKAN HUTANG DAN KEBIJAKAN DIVIDEN TERHADAP NILAI PERUSAHAAN (STUDI KASUS PADA PT.UNILEVER INDONESIA TBK)
Authors: Musyaffa Muhammad Rifqy , Mulyadi Endang , Sukomo Sukomo 
Published: July 2024

Adapun rumusan masalah dalam penelitian ini yaitu : 1) Seberapa besar pengaruh kebijakan hutang terhadap nilai perusahaan pada PT.Unilever indonesia Tbk. 2) Seberapa besar pengaruh kebijakan dividen terhadap dengan nilai perushaan pada PT.Unilever Indonesia Tbk. 3) Seberapa besar pengaruh kebijakan hutang dan kebijakan dividen terhadap nilai perusahaan. Tujuaan penelitian ini yaitu: 1) Untuk mengetahui besarnya pengaruh kebijakan hutang terhadap nilai perusahaan pada PT.Unilever Indonesia Tbk. 2) Untuk mengetahuai besar pengaruh kebijakan dividen terhadap nilai perusahaan pada PT.Unilever Indonesia Tbk. 3).Untuk mengetahui seberapa besar pengaruh kebijakan hutang dan kebijakan dividen terhadap nilai perusahaan pada PT.Unilever Indonesia Tbk. metode penelitian ini mengunakan metode analisis deskriptif dengan pendekatan kuantitatif. Hasil penelitian menunjukan bahwa : 1) kebijakan hutang berpengaruh positif dan tidak signifikan terhadap nilai perusahaan artinya naik turunya kebijakan hutang tidak berpengaruh signifikan terhadap naik turunya nilai perusahaan pada PT.Unilever Indonesia Tbk periode 2017-2022. 2) kebijakan dividen berpengaruh positif dan tidak signifikan terhadap nilai perusahaan artinya naik turunya kebijakan dividen tidak berpengaruh signifikan terhadap naik turunya nilai perusahaan pada PT.Unilever Indonesia Tbk periode 2017-2022. 3)kebijakan hutang dan kebijakan dividen berpengaruh positif tetapi tidak signifikan terhadap nilai perusahaan artinya naik turunya kebijakan hutang dan kebijakan dividen tidak berpengaruh signifikan terhadap naik turunya nilai perusahaan pada PT.Unilever Indonesia Tbk periode 2017-2022.
The effect of reverence (‘Khushoo’) in Muslim prayer on cardiovascular responses
Authors: Aldahadha Basim 
Published: July 2024

A Muslim usually prays 5 times a day, is obligatory for every Muslim. Prayer includes many movements and postures, and measure of reverence in Muslim prayer (MRMP) is an essential part of accepting this practice. This study aimed to explore the effectiveness of MRMP on some cardiovascular responses (CRs). The study sample consisted of 74 students (36 = males, 38= females) with ages ranging from 18 to 20 years (M = 19.44, SD = 0.74). The participants were from Jadara University (Jordan) and were selected according to the degree of their responses to both sides of MRMP. They were divided into two groups: a high MRMP group (N = 37), who obtained the highest scores on the MRMP scale, and a low MRMP group (N= 37), who had the lowest scores on MRMP. The high MRMP group was trained on the items of MRMP and reminded of them, while the low MRMP group did not receive any kind of training. The results showed that there was a decrease in the after measurements of pulse (F = 12.326, p = 0.001), systolic blood pressure (F = 30.331, p = 0.001) and diastolic blood pressure (F = 18.375, p = 0.001), while the results did not show an effect on the oxygen level. The results did not show an effect of sex, nor an interaction between group and sex. The results of this study supported the importance of MRMP and its positive impact on the health of the body, the circulatory system, and heart health as a result of mental health.
Exploring Student Engagement Predictors for Working Students: The Role of Self-Esteem and Social Support with Resilience As Mediator
Authors: Rahayu Anizar , Fachmi Teguh , Burhanudin Mohammad Daffa 
Published: July 2024

This research uses structural equation modelling (SEM) technique to investigate and comprehend the dynamics of student engagement among working students, with a particular emphasis on the effects of self-esteem and social support mediated by resilience. It also aims to discover the complex relationships between those variables and to identify the mechanisms that help to improve student engagement. Total numbers (n)=340 working students were taken as sample, self-report questionnaire was applied. Research known that self-esteem don’t affect student engagement directly, but indirect results of the study showed that resilience significantly mediated the relationship between self-esteem and student engagement. Social support also had a significant direct effect on student engagement, and resilience significantly mediated the relationship between social support and student engagement.
BIOCHEMICAL AND HISTOLOGICAL STUDIES ON ADVERSE EFFECTS OF DIETARY WEIGHT LOSS SUPPLEMENT ON FEMALE RATS: ADIOS
Authors: Mohammed Noor A. 
Published: July 2024

Herbal and dietary supplements are commonly used throughout the world; these unlicensed supplements are not recommended due to concerns about their clinical efficacy and safety. Adios are marketed for weight loss in Iraq and many other countries and are commonly used by women. The safety of these weight loss aids is unknown. This study aimed to evaluate adios adverse effects by conducting biochemical, hematological, and histological examinations on the liver and kidney. Rats were orally administrated for 30 days with different concentrations of adios supplements (0.001g/100g), (0.002g/100g), and (0.003g/100g) as low (LD) medium (MD) and high (HD) concentrations, respectively. The results showed no weight loss in rats over 30 days across experiments in all the treated groups (LD, MD, and HD) compared to the control. Adios showed significant differences between the control and the treated concentrations in the following hematological parameters: white blood cells (WBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), lymphocyte (LYM), and red cell distribution width (RDW) in a dose-dependent pattern. Furthermore, there were various alteration in the histopathological examination of the kidney and liver. From the current data, it can be concluded that adios has zero efficacy in weight loss and is not recommended for use because it has adverse effects on many hematological and biochemical parameters and with obvious pathological changes in both the kidney and liver.
About the Heritage of Klavdiya Alexandrovna Novikova in the Holdings of the National Library of the Republic of Sakha (Yakutia)
Authors: Zakharova Ekaterina I. 
Published: July 2024

The study of the donated collection of K.A. Novikova (1913—1984), a leading northern scholar and specialist in Tungus-Manchurian languages, was carried out. The scientist’s collection was given to the National Library (NL) of the Republic of Sakha (Yakutia) by K.A. Novikova’s younger daughter I.L. Bochanova (Sobolevskaya) in 1993 in the amount of 328 books and 37 manuscripts. At present it is part of the gift collection of the NL of the Republic of Sakha (Yakutia). These are unique materials reflecting the owner’s individuality, his scientific interests, and also acting as a document of their era, an invaluable cultural artefact. The concepts of ‘donation’ and ‘donated collection’ are clarified. Types of review and analytical materials devoted to books and manuscripts of the collection are revealed. Cultural knowledge about their owners, readers, researchers, etc. is expanded by new interpretations and practices of rare editions.The history of creation, transfer and use of K.A. Novikova’s donation in the holdings of the NL of the Republic of Sakha (Yakutia) is shown. Its formation and functioning are analyzed. Many books have gift inscriptions of the authors, which reveal the relationship between the owner and his contemporaries and at the same time serve as evidence of the history of the book collection formation. The data of the analysis of the demand for the books of the collection from the electronic library of the NL of the Republic of Sakha (Yakutia) for the last 5 years are given. The composition of the main scientific works on Even language and folklore and manuscripts, which contain a variety of information, has been studied. The materials of the collection are of cultural value. The heritage of the northern indigenous peoples is an asset of our country’s history and culture.