bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tate properties, polynomial-count varieties, and monodromy of hyperplane arrangements
Authors: Dimca Alexandru 
Published: May 2015

AbstractThe order of the Milnor fiber monodromy operator of a central hyperplane arrangement is shown to be combinatorially determined. In particular, a necessary and sufficient condition for the triviality of this monodromy operator is given.It is known that the complement of a complex hyperplane arrangement is cohomologically Tate and, if the arrangement is defined over ℚ, has polynomial count. We show that these properties hold for the corresponding Milnor fibers if the monodromy is trivial.We construct a hyperplane arrangement defined over ℚ, whose Milnor fiber has a nontrivial monodromy operator, is cohomologically Tate, and has no polynomial count. Such examples are shown not to exist in low dimensions.
Localized Morrey-Campanato spaces on metric measure spaces and applications to Schrüdinger operators
Authors: Yang Dachun , Yang Dongyong , Zhou Yuan 
Published: May 2015

AbstractLet be a space of homogeneous type in the sense of Coifman and Weiss, and let be a collection of balls in . The authors introduce the localized atomic Hardy space the localized Morrey-Campanato space and the localized Morrey-Campanato-BLO (bounded lower oscillation) space with α ∊ ℝ and p ∊ (0, ∞) , and they establish their basic properties, including and several equivalent characterizations for In particular, the authors prove that when α > 0 and p ∊ [1, ∞), then and when p ∈(0,1], then the dual space of is Let ρ be an admissible function modeled on the known auxiliary function determined by the Schrödinger operator. Denote the spaces and , respectively, by and when is determined by ρ. The authors then obtain the boundedness from of the radial and the Poisson semigroup maximal functions and the Littlewood-Paley g-function, which are defined via kernels modeled on the semigroup generated by the Schrödinger operator. These results apply in a wide range of settings, for instance, the Schrödinger operator or the degenerate Schrödinger operator on ℝd, or the sub-Laplace Schrödinger operator on Heisenberg groups or connected and simply connected nilpotent Lie groups.
On the boundary of the moduli spaces of log Hodge structures: Triviality of the torsor
Authors: Hayama Tatsuki 
Published: May 2015

AbstractThis paper examines the moduli spaces of log Hodge structures introduced by Kato and Usui. This moduli space is a partial compactification of a discrete quotient of a period domain. This paper treats the following two cases: (A) where the period domain is Hermitian symmetric, and (B) where the Hodge structures are of the mirror quintic type. Especially it addresses a property of the torsor.
The norm of a Ree group
Authors: Medts Tom De , Weiss Richard M. 
Published: May 2015

AbstractWe give an explicit construction of the Ree groups of type G2 as groups acting on mixed Moufang hexagons together with detailed proofs of the basic properties of these groups contained in the two fundamental papers of Tits on this subject (see [7] and [8]). We also give a short proof that the norm of a Ree group is anisotropic.
Birational classification of curves on rational surfaces
Authors: Calabri Alberto , Ciliberto Ciro 
Published: May 2015

AbstractIn this paper we consider the birational classification of pairs (S, ℒ), with S a rational surface and ℒ a linear system on S. We give a classification theorem for such pairs, and we determine, for each irreducible plane curve B, its Cremona minimal models, that is, those plane curves which are equivalent to B via a Cremona transformation and have minimal degree under this condition.
Dynamical construction of Kähler-Einstein metrics
Authors: Tsuji Hajime 
Published: May 2015

AbstractIn this article, we give a new construction of a Kähler-Einstein metric on a smooth projective variety with ample canonical bundle. As a consequence, for a dominant projective morphism f: X → S with connected fibers such that a general fiber has an ample canonical bundle, and for a positive integer m, we construct a canonical singular Hermitian metric hE,m on with semipositive curvature in the sense of Nakano.
On the second Gaussian map for curves on a K3 surface
Authors: Colombo Elisabetta , Frediani Paola 
Published: May 2015

AbstractBy a theorem of Wahl, for canonically embedded curves which are hyperplane sections of K3 surfaces, the first Gaussian map is not surjective. In this paper we prove that if C is a general hyperplane section of high genus (> 280) of a general polarized K3 surface, then the second Gaussian map of C is surjective. The resulting bound for the genus g of a general curve with surjective second Gaussian map is decreased to g > 152.
Mean representation number of integers as the sum of primes
Authors: Bhowmik Gautami , Schlage-Puchta Jan-Christoph 
Published: May 2015

AbstractAssuming the Riemann hypothesis, we obtain asymptotic estimates for the mean value of the number of representations of an integer as a sum of two primes. By proving a corresponding Ω-term, we show that our result is essentially the best possible.
On Waring’s problem: Three cubes and a minicube
Authors: Brüdern Jörg , Wooley Trevor D. 
Published: May 2015

AbstractWe establish that almost all natural numbers n are the sum of four cubes of positive integers, one of which is no larger than n5/36. The proof makes use of an estimate for a certain eighth moment of cubic exponential sums, restricted to minor arcs only, of independent interest.
Quasi-socle ideals in Buchsbaum rings
Authors: Goto Shiro , Horiuchi Jun , Sakurai Hideto 
Published: May 2015

AbstractQuasi-socle ideals, that is, ideals of the form I = Q: mq (q ≥ 2), with Q parameter ideals in a Buchsbaum local ring (A,m), are explored in connection to the question of when I is integral over Q and when the associated graded ring G(I) ⊕ n≥0In/In+1 of I is Buchsbaum. The assertions obtained by Wang in the Cohen-Macaulay case hold true after necessary modifications of the conditions on parameter ideals Q and integers q. Examples are explored.
Derived equivalences and stable equivalences of Morita type, I
Authors: Hu Wei , Xi Changchang 
Published: May 2015

AbstractFor self-injective algebras, Rickard proved that each derived equivalence induces a stable equivalence of Morita type. For general algebras, it is unknown when a derived equivalence implies a stable equivalence of Morita type. In this article, we first show that each derived equivalenceFbetween the derived categories of Artin algebrasAandBarises naturally as a functorbetween their stable module categories, which can be used to compare certain homological dimensions ofAwith that ofB. We then give a sufficient condition for the functorto be an equivalence. Moreover, if we work with finite-dimensional algebras over a field, then the sufficient condition guarantees the existence of a stable equivalence of Morita type. In this way, we extend the classical result of Rickard. Furthermore, we provide several inductive methods for constructing those derived equivalences that induce stable equivalences of Morita type. It turns out that we may produce a lot of (usually not self-injective) finite-dimensional algebras that are both derived-equivalent and stably equivalent of Morita type; thus, they share many common invariants.
Distribution of polynomials with cycles of a given multiplier
Authors: Bassanelli Giovanni , Berteloot François 
Published: May 2015

AbstractIn the space of degree d polynomials, the hypersurfaces defined by the existence of a cycle of period n and multiplier eiθ are known to be contained in the bifurcation locus. We prove that these hypersurfaces equidistribute the bifurcation current. This is a new result, even for the space of quadratic polynomials.
The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the Drosophila eye
Authors: Wittkorn Erika , Sarkar Ankita , Garcia Kristine , Kango-Singh Madhuri , Singh Amit 
Published: May 2015

ABSTRACT
The evolutionarily conserved Hippo signaling pathway is known to regulate cell proliferation and maintain tissue homeostasis during development. We found that activation of Yorkie (Yki), the effector of the Hippo signaling pathway, causes separable effects on growth and differentiation of the Drosophila eye. We present evidence supporting a role for Yki in suppressing eye fate by downregulation of the core retinal determination genes. Other upstream regulators of the Hippo pathway mediate this effect of Yki on retinal differentiation. Here, we show that, in the developing eye, Yki can prevent retinal differentiation by blocking morphogenetic furrow (MF) progression and R8 specification. The inhibition of MF progression is due to ectopic induction of Wingless (Wg) signaling and Homothorax (Hth), the negative regulators of eye development. Modulating Wg signaling can modify Yki-mediated suppression of eye fate. Furthermore, ectopic Hth induction due to Yki activation in the eye is dependent on Wg. Last, using Cut (Ct), a marker for the antennal fate, we show that suppression of eye fate by hyperactivation of yki does not change the cell fate (from eye to antenna-specific fate). In summary, we provide the genetic mechanism by which yki plays a role in cell fate specification and differentiation – a novel aspect of Yki function that is emerging from multiple model organisms.
Essential elements for translation: the germline factor Vasa functions broadly in somatic cells
Authors: Yajima Mamiko , Wessel Gary M. 
Published: May 2015

ABSTRACT
Vasa is a conserved RNA-helicase found in the germ lines of all metazoans tested. Whereas Vasa presence is often indicated as a metric for germline determination in animals, it is also expressed in stem cells of diverse origin. Recent research suggests, however, that Vasa has a much broader function, including a significant role in cell cycle regulation. Results herein indicate that Vasa is utilized widely, and often induced transiently, during development in diverse somatic cells and adult precursor tissues. We identified that Vasa in the sea urchin is essential for: (1) general mRNA translation during embryogenesis, (2) developmental re-programming upon manipulations to the embryo and (3) larval wound healing. We also learned that Vasa interacted with mRNAs in the perinuclear area and at the spindle in an Importin-dependent manner during cell cycle progression. These results suggest that, when present, Vasa functions are essential to contributing to developmental regulation.
Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin–Gαi3 signaling
Authors: Sasaki Kazunori , Kakuwa Taku , Akimoto Kazunori , Koga Hisashi , Ohno Shigeo 
Published: May 2015

ABSTRACT
Epithelial apicobasal polarity has fundamental roles in epithelial physiology and morphogenesis. The PAR complex, comprising PAR-3, PAR-6 and atypical protein kinase C (aPKC), is involved in determining cell polarity in various biological contexts, including in epithelial cells. However, it is not fully understood how the PAR complex induces apicobasal polarity. In this study, we found that PAR-3 regulates the protein expression of Girdin (also known as GIV or CCDC88A), a guanine-nucleotide-exchange factor (GEF) for heterotrimeric Gαi subunits, at the transcriptional level by cooperating with the AP-2 transcription factor. In addition, we confirmed that PAR-3 physically interacts with Girdin, and show that Girdin, together with the Gαi3 (also known as GNAI3), controls tight junction formation, apical domain development and actin organization downstream of PAR-3. Taken together, our findings suggest that transcriptional upregulation of Girdin expression and Girdin–Gαi3 signaling play crucial roles in regulating epithelial apicobasal polarity through the PAR complex.
A role for F-BAR protein Rga7p during cytokinesis in S. pombe
Authors: Arasada Rajesh , Pollard Thomas D. 
Published: May 2015

ABSTRACT
F-BAR proteins are known to participate in cytokinesis, but their mechanisms are not well understood. Here we investigated Rga7p, an Schizosaccharomyces pombe F-BAR protein with a RhoGAP domain. Localization of Rga7p to the cytokinetic cleavage furrow depends on its F-BAR domain, actin filaments, the formins Cdc12p and For3p, and the presence of a contractile ring. Rga7p is not required for the constriction of the contractile ring but does participate in the transport of a β-glucan synthetase (Bgs4p) from the late Golgi compartments to plasma membrane that is adjacent to the contractile ring. Cells without Rga7p moved Bgs4p normally from the poles to the Golgi complex near to the cell center, but Bgs4p then moved slowly from the late Golgi compartments to the cleavage site. The late arrival and lower than normal numbers of Bgs4p result in septal defects late in cytokinesis, and in the lysis of separating cells, similar to that in cells with mutations in the cwg1+ gene (which encodes Bgs4p).
Negative feedback from CaSR signaling to aquaporin-2 sensitizes vasopressin to extracellular Ca2+
Authors: Ranieri Marianna , Tamma Grazia , Di Mise Annarita , Russo Annamaria , Centrone Mariangela , Svelto Maria , Calamita Giuseppe , Valenti Giovanna 
Published: May 2015

ABSTRACT
We previously described that high luminal Ca2+ in the renal collecting duct attenuates short-term vasopressin-induced aquaporin-2 (AQP2) trafficking through activation of the Ca2+-sensing receptor (CaSR). Here, we evaluated AQP2 phosphorylation and permeability, in both renal HEK-293 cells and in the dissected inner medullary collecting duct, in response to specific activation of CaSR with NPS-R568. In CaSR-transfected cells, CaSR activation drastically reduced the basal levels of AQP2 phosphorylation at S256 (AQP2-pS256), thus having an opposite effect to vasopressin action. When forskolin stimulation was performed in the presence of NPS-R568, the increase in AQP2-pS256 and in the osmotic water permeability were prevented. In the freshly isolated inner mouse medullar collecting duct, stimulation with forskolin in the presence of NPS-R568 prevented the increase in AQP2-pS256 and osmotic water permeability. Our data demonstrate that the activation of CaSR in the collecting duct prevents the cAMP-dependent increase in AQP2-pS256 and water permeability, counteracting the short-term vasopressin response. By extension, our results suggest the attractive concept that CaSR expressed in distinct nephron segments exerts a negative feedback on hormones acting through cAMP, conferring high sensitivity of hormone to extracellular Ca2+.
Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin
Authors: Garcia-Castillo Maria Daniela , Tran Thi , Bobard Alexandre , Renard Henri-François , Rathjen Stefan J. , Dransart Estelle , Stechmann Bahne , Lamaze Christophe , Lord Mike , Cintrat Jean-Christophe , Enninga Jost , Tartour Eric , Johannes Ludger 
Published: May 2015

ABSTRACT
Antigen-presenting cells have the remarkable capacity to transfer exogenous antigens to the cytosol for processing by proteasomes and subsequent presentation on major histocompatibility complex class-I (MHC-I) molecules, a process termed cross-presentation. This is the target of biomedical approaches that aim to trigger a therapeutic immune response. The receptor-binding B-subunit of Shiga toxin (STxB) has been developed as an antigen delivery tool for such immunotherapy applications. In this study, we have analyzed pathways and trafficking factors that are involved in this process. A covalent conjugate between STxB and saporin was generated to quantitatively sample the membrane translocation step to the cytosol in differentiated monocyte-derived THP-1 cells. We have found that retrograde trafficking to the Golgi complex was not required for STxB–saporin translocation to the cytosol or for STxB-dependent antigen cross-presentation. Depletion of endosomal Rab7 inhibited, and lowering membrane cholesterol levels favored STxB–saporin translocation. Interestingly, experiments with reducible and non-reducible linker-arm–STxB conjugates led to the conclusion that after translocation, STxB remains associated with the cytosolic membrane leaflet. In summary, we report new facets of the endosomal escape process bearing relevance to antigen cross-presentation.
It's never too late to publish an abandoned trial
Authors: Shiles Celia , Sinclair Julia 
Published: May 2015

It is estimated that half of all trials have never been published which can lead to patients being denied the most effective treatment and being exposed to unnecessary side effects. Furthermore the trial participants have been misinformed since the trial results have not contributed to the care of future patients.However the non-publication of trials is often not due to a deliberate decision to cover up results. Commonly in academia it is due to more understandable reasons such as researchers having busy clinical posts, moving onto other more demanding projects, changing research areas or starting a family. This is called the “file drawer” problem.The examples in this editorial demonstrate that it is possible to go back, even decades later, and make the results available to inform future evidence based medicine. We call on others to look into their “file drawer” for unpublished trials.
Diagnostic Assessment of Teachers� ICT-competency
Authors: �������  , Alferov M. , ��������  , Paromova S. , �������  , Nevskaya O. , ��������  , Fedorova Yuliya , �������  , Kalinin A. 
Published: May 2015

The article describes the results of the collaborative work of the Moscow Institute of Open Education and UNESCO IITE on the system of international
assessment and certification of teachers� competencies and capabilities in the area of ICT use in classroom practices.
The technologies used in diagnostic assessment of ICT-competency in teachers in relation to the UNESCO Information and Communication Tools Competency
Framework for Teachers (ICT-CFT) at the First Centre for Certification at the Moscow Institute of Open Education are detailed. Statistical data
from assessment results of about 6 thousand subject teachers of Moscow in years 2012-2014 is presented and analyzed. Tendencies in the dynamics of
the assessment results are discussed, and the functional role of the assessment system in improving quality of education is formulated
What the Bologna Process Means for the Russian Education System?
Authors: ��������  , Saburova Marina , �������  , Galeeva R. 
Published: May 2015

The paper describes the results of the expert survey among the respondents of the Ulyanovsk region devoted to the problem of the impact of the Bologna
system on the quality of higher education in Russia and the problem of employment of university graduates, which was held within the project
&#34;Investigation of the higher education system: harmonization of relations between the labor market and the market of educational services.&#34; The study
involved representatives of government, higher education and business in the region. Different points of view on the reform of higher education in Russia
are presented, an analytical conclusion, how the Bologna system is perceived by Russian society on an example of the region, is made. It should be
noted, there was not the consensus among the government, business and higher education of the Ulyanovsk region whether the Bologna system carries
the benefit of Russian society or not.
Portfolio Choice with Market Closure and Implications for Liquidity Premia
Authors: Dai Min , Li Peifan , Liu Hong , Wang Yajun 
Published: May 2015

Most existing portfolio choice models ignore the prevalent periodic market closure and the fact that market volatility is significantly higher during trading periods. We find that market closure and the volatility difference across trading and nontrading periods significantly change optimal trading strategies. In addition, we demonstrate numerically that transaction costs can have a first-order effect on liquidity premia that is largely comparable to empirical findings. Moreover, this effect on liquidity premia increases in the volatility difference, which is supported by our empirical analysis. This paper was accepted by Jerome Detemple, finance.
The Impact of Walmart Supercenter Conversion on Consumer Shopping Behavior
Authors: Hwang Minha , Park Sungho 
Published: May 2015

This paper presents an empirical study of the impact of Walmart supercenter conversion on consumer shopping behavior. By using a difference-in-difference estimator, we find that Walmart gains 41% in weekly revenue from the conversion. Decomposing the revenue gains into components attributable to store visits and per-visit expenditures, we find that the majority of these gains were due to larger expenditures, with a much smaller impact from store visits. By contrast, among competing retailers, grocery stores experience the most significant loss (20% weekly revenue) mostly from fewer store visits, with a much smaller impact attributable to per-visit expenditure. Taken together, these findings show that consumers may benefit from reduced shopping costs by making fewer overall trips and increasing their Walmart basket sizes. In addition, we find that overall revenue gains for Walmart from conversion outweigh the small cannibalization loss at the existing Walmart supercenters located farther away. Finally, from category-level analyses, we find evidence of increases in category-level spending in preexisting categories in the converted supercenter. However, we also find that positive demand externality is more pronounced in food categories, mainly as a result of increased purchase incidence. We discuss the implications of our findings for academics and retail managers. This paper was accepted by Pradeep Chintagunta, marketing.
Noninvasive Detection of Activating Estrogen Receptor 1 (ESR1) Mutations in Estrogen Receptor–Positive Metastatic Breast Cancer
Authors: Guttery David S , Page Karen , Hills Allison , Woodley Laura , Marchese Stephanie D , Rghebi Basma , Hastings Robert K , Luo Jinli , Pringle J Howard , Stebbing Justin , Coombes R Charles , Ali Simak , Shaw Jacqueline A 
Published: May 2015

Abstract

BACKGROUND
Activating mutations in the estrogen receptor 1 (ESR1) gene are acquired on treatment and can drive resistance to endocrine therapy. Because of the spatial and temporal limitations of needle core biopsies, our goal was to develop a highly sensitive, less invasive method of detecting activating ESR1 mutations via circulating cell-free DNA (cfDNA) and tumor cells as a “liquid biopsy.”

METHODS
We developed a targeted 23-amplicon next-generation sequencing (NGS) panel for detection of hot-spot mutations in ESR1, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA), tumor protein p53 (TP53), fibroblast growth factor receptor 1 (FGFR1), and fibroblast growth factor receptor 2 (FGFR2) in 48 patients with estrogen receptor-α–positive metastatic breast cancer who were receiving systemic therapy. Selected mutations were validated using droplet digital PCR (ddPCR).

RESULTS
Nine baseline cfDNA samples had an ESR1 mutation. NGS detected 3 activating mutations in ESR1, and 3 hot-spot mutations in PIK3CA, and 3 in TP53 in baseline cfDNA, and the ESR1 p.D538G mutation in 1 matched circulating tumor cell sample. ddPCR analysis was more sensitive than NGS and identified 6 additional baseline cfDNA samples with the ESR1 p.D538G mutation at a frequency of &lt;1%. In serial blood samples from 11 patients, 4 showed changes in cfDNA, 2 with emergence of a mutation in ESR1. We also detected a low frequency ESR1 mutation (1.3%) in cfDNA of 1 primary patient who was thought to have metastatic disease but was clear by scans.

CONCLUSIONS
Early identification of ESR1 mutations by liquid biopsy might allow for cessation of ineffective endocrine therapies and switching to other treatments, without the need for tissue biopsy and before the emergence of metastatic disease.