bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factor V haemostatic diathesis impairing thrombin activation, membrane binding and circulating antigen level due to a novel compound heterozygous mutation, Leu1821Ser and Gly2192Cys
Authors: Talbot Kimberley , Song Jina , Perrier John R. , Jackson Shannon , MacGillivray Ross T. A. , Pryzdial Edward L. G. 
Published: August 2024

AbstractIntroductionCongenital factor V (FV) deficiency is a rare clotting disorder affecting ∼1 in 1,000,000, with bleeding severity that ranges broadly for poorly understood reasons.AimTo help understand the molecular basis of the observed phenotype in FV deficient patients, the genetics and biochemistry causing a patient's FV deficiency were evaluated.Methods and ResultsA 71‐year‐old female, who had serious life‐long bleeding upon provocation and profound menorrhagia that lead to hysterectomy, was found to have 3% of normal plasma FV antigen with normal electrophoretic mobility. Platelet FV was similarly low, although the banding pattern was less fragmented than normal. Plasma clotting activity was <1% of normal. Familial inheritance and DNA sequence analysis from peripheral blood leukocytes were consistent with novel compound heterozygosity with missense mutations in exon XVII, Leu1821 to Ser (L1821S) and exon XXV, Gly2192 to Cys (G2192C). The respective single‐mutation variants were expressed and purified. Explaining why the antigen level and activity were inequivalent, thrombin activation of recombinant (r) FV/L1821S was impaired, and rFV/G2192C was unable to bind to a procoagulant phospholipid membrane.ConclusionThese findings are consistent with the observed phenotype, highlighting the importance of understanding FV biochemical function to rationalize clinical bleeding severity when the circulating antigen level is discordant.
The dynamics of L2 teacher boredom and their link to creativity: A ban or boon for boredom
Authors: Elahi Shirvan Majid , Taherian Tahereh , Pawlak Mirosław , Kruk Mariusz 
Published: August 2024

AbstractResearch has revealed a prevalence of boredom among L2 teachers, despite efforts to mitigate this negative emotion. The interplay between teacher boredom and creativity, especially their concurrent development, has not been extensively studied longitudinally. Utilizing control‐value theory as its foundation, this study investigates the daily progression of boredom and creativity among L2 teachers, their mutual development, and how control‐value beliefs influence these dynamics. A 5‐day experience sampling method study involving 98 L2 teachers generated 423 observations. Dynamic structural equation modeling (DSEM) was employed at the individual (Level 1) and group (Level 2) levels. DSEM results revealed varied relationships between boredom and creativity changes over a week, influenced by teachers’ control and value beliefs. In innovators, with high perceived control and intrinsic value beliefs and moderate to high extrinsic value beliefs, previous experiences of boredom might positively influence the teacher's creativity the next day. This creativity might, in turn, decrease the teacher's boredom. This suggests a potential positive relationship between boredom and creativity in innovative language teachers. In adaptors, with moderate perceived control and intrinsic value beliefs and medium to low extrinsic value beliefs, previous experiences of boredom did not necessarily influence the teacher's creativity the next day. However, teacher creativity might still decrease teacher boredom. For traditionalists, with medium perceived control and intrinsic value beliefs and moderate to high extrinsic value beliefs, previous experiences of boredom might have decreased the teacher's creativity the next day, while teacher creativity might have decreased the teacher's boredom the same day. Finally, in dissatisfied teachers with low perceived control, intrinsic value, and extrinsic value beliefs, previous experiences of boredom might have decreased the teacher's creativity the next day, while teacher creativity might not necessarily predict the teacher's boredom. Results suggest a reciprocal relationship between boredom and creativity in adaptable and traditionalist teachers. Additionally, Level 2 analysis identified correlations between random effect parameters across four clusters.
A new species of Kannaphallus (Polyopisthocotylea: Heteraxinidae) parasitic on the twobar seabream Acanthopagrus bifasciatus (Sparidae, Teleostei) in Saudi Arabia
Authors: Alojayri Ghada , Abdel‐Gaber Rewaida , Mohammed Osama B. , Al‐Otaibi Tahani , Al‐Malki Esam S. , Al‐Hoshani Nawal , Almayouf Mina A. , Al‐Shaebi Esam , Al‐Quraishy Saleh 
Published: August 2024

AbstractMonogeneans are highly host‐specific parasites infecting marine and freshwater fish. However, little information is available about the parasitic taxa within Heteraxinidae. An integrative study was performed to understand the taxonomic status of an unconfirmed heteraxinid marine species parasitizing the gill region of Acanthopagrus bifasciatus (Sparidae) from the Arabian Gulf (Saudi Arabia). Based on the morphological study, this parasite has all the generic features of the genus Kannaphallus (Heteraxinidae, Mazocraeidea). Distinct criteria that discriminated this species from other taxa of the same genus are the presence of genital spines (26–29), a short sclerotized duct in the male copulatory organ, the number of testes (mean 40, range 30–50), and clamps in the haptoral structure (45–50 in a long row and 19–22 in a short row). DNA of parasite species reported in the present study was amplified and sequenced for the nuclear large subunit of the ribosomal RNA (28S rRNA) gene and the mitochondrial cytochrome c oxidase subunit I (COI) gene. Results indicate that sequences obtained from both genes are unique and different from related sequences from the genus Kannaphallus. Morphological as well as molecular data indicate that our specimens are from a new species, and the name Kannaphallus acanthopagrusi n. sp. is suggested. This is the first report of a heteraxinid parasitizing marine sparid fish from Saudi Arabia, with unique morphological and molecular features.
Parent–adolescent family resilience and psychological adjustment in chronically ill adolescents: An actor–partner interdependence mediation model
Authors: Chen Meijia , Chen Xiuping , Jiang Hao , Wang Yuxin , Ren Liya , Zhang Liping , Dong Chaoqun 
Published: August 2024

AbstractAimsThis study explored the relationships between family resilience, dyadic coping and psychological adjustment among adolescents with chronic illnesses and their parents. The actor–partner interdependence mediation model was used to validate the mediating role of dyadic coping in the relationship between family resilience and psychological adjustment.DesignThis is a cross‐sectional study.MethodsA total of 318 parent–adolescents dyads were recruited from three paediatric hospitals in Wenzhou, Hangzhou, Shanghai city, China, between June 2022 and August 2023. The parents had a mean age of 41.62 years, and the adolescents had a mean age of 12.66 years. Participants independently completed a self‐report questionnaire assessed family resilience, dyadic coping and psychological adjustment. Data analysis was conducted using the actor–partner interdependence mediation model.ResultsThe findings suggest that in the actor effects, family resilience directly influenced psychological adjustment, and family resilience is related to psychological adjustment through positive dyadic coping. In the partner effect, parents' family resilience influenced adolescents' psychological adjustment through the parents' positive dyadic coping. Similarly, adolescents' family resilience influenced parents' psychological adjustment through both parents' positive dyadic coping and adolescents' negative dyadic coping. Additionally, there was a partner effect between parents' family resilience and adolescents' psychological adjustment.ConclusionThis study demonstrated the importance of developing effective dyadic interventions based on family resilience or positive dyadic coping strategies to improve the mental health of adolescents with chronic illnesses and their parents.ImpactThe mediating role of dyadic coping in the relationship between family resilience and psychological adjustment among adolescents with chronic illnesses and their parents was demonstrated. Future psychosocial interventions should focus on increasing parents' positive dyadic coping strategies and improving adolescents' negative dyadic coping strategies.Patient or Public ContributionNo patient or public contribution.
Comparing effects of different goal type orders on collaborative simulation‐based inquiry in engineering problem solving: A process modelling approach
Authors: Sun Yanyan , Feng Chengjun , Peng Di , Wu Bian 
Published: August 2024

AbstractBackgroundBoth learning and problem solving are major goals of complex problem solving in engineering education. The order of knowledge construction and problem solving in learning through problem solving, however, has not been explained in current literature.ObjectivesTo understand their relationships, this study compared the effects of different goal type orders on collaborative simulation‐based inquiry in engineering problem solving.MethodsIn the study, 24 engineering undergraduate students worked in pairs to solve a wind tunnel problem using a computer simulation application. Process mining and epistemic network analysis were used to model the inquiry process and identify inquiry patterns based on the log data and discussion discourse.Results and ConclusionsThe results showed the goal type of first assigned subtask influenced the inquiry strategies of medium‐performance learners most. In addition, the goal type of first assigned subtask had influence on learners' inquiry process. The learners assigned with a problem‐solving goal subtask first (Problem solving goal‐Learning goal condition) had more simulation trials and centered their inquiry discourse around clarification while the learners assigned with a learning goal subtask first (Learning goal‐Problem solving goal condition) connected reflection with other inquiry phases more often. The findings of this study suggested assigning a learning goal subtask first in simulated‐based complex engineering problem solving could be used as an idea‐centered scaffolding, especially for medium‐performance learners. However, low‐performance learners would experience a “situate knowledge paradox” and needs extra guidance. It is important to monitor the knowledge construction process in complex problem solving, even when seeking a solution is the major task.
Isoliquiritigenin diminishes invasiveness of human nasopharyngeal carcinoma cells associating with inhibition of MMP‐2 expression and STAT3 signalling
Authors: Lu Yen‐Ting , Hsin Chung‐Han , Kao Shao‐Hsuan , Ho Yu‐Ting , Yeh Fang‐Ling , Yang Shun‐Fa , Lin Chiao‐Wen 
Published: August 2024

AbstractNasopharyngeal carcinoma (NPC) is prevalent in Asia and exhibits highly metastatic characteristics, leading to uncontrolled disease progression. Isoliquiritigenin (ISL) have attracted attention due to their diverse biological and pharmacological properties, including anticancer activities. However, the impact of ISL on the invasive and migratory ability of NPC remains poorly understood. Hence, this study aimed to investigate the in vitro anti‐metastatic effects of ISL on NPC cells and elucidate the underlying signalling pathways. Human NPC cell NPC‐39 and NPC‐BM were utilized as cell models. Migratory and invasive capabilities were evaluated through wound healing and invasion assays, respectively. Gelatin zymography was employed to demonstrate matrix metalloproteinase‐2 (MMP‐2) activity, while western blotting was conducted to analyse protein expression levels and explore signalling cascades. Overexpression of signal transducer and activator of transcription 3 (STAT3) was carried out by transduction of STAT3‐expressing vector. Our findings revealed that ISL effectively suppressed the migration and invasion of NPC cells. Gelatin zymography and Western blotting assays demonstrated that ISL treatment led to a reduction in MMP‐2 enzyme activity and protein expression. Investigation of signalling cascades revealed that ISL treatment resulted in the inhibition of STAT3 phosphorylation. Moreover, overexpression of STAT3 restored the migratory ability of NPC cells in the presence of ISL. Collectively, these findings indicate that ISL inhibits the migration and invasion of NPC cells associating with MMP‐2 downregulation through suppressing STAT3 activation. This suggests that ISL has an anti‐metastatic effect on NPC cells and has potential therapeutic benefit for NPC treatment.
Effectiveness of digital interventions to reduce school‐age adolescent sexual risks: A systematic review
Authors: Aguilar‐Quesada Ana , Sierra‐Yagüe Alba , González‐Cano‐Caballero María , Zafra‐Egea José Antonio , Lima‐Serrano Marta 
Published: August 2024

AbstractIntroductionThe increase in risky sexual behaviors among adolescent students has sparked alarm and has become an area of research interest. As adolescents prioritize confidentiality and accessibility, digital interventions are becoming increasingly relevant in sex education. We therefore posed the following research question: Are digital application interventions effective to prevent risky sexual behaviors in school adolescents?DesignA systematic peer review was conducted between January and December 2023 in five databases (PubMed, Web of Science, Scopus, EMBASE, and PsycINFO) without restricting for language or year of publication.MethodWe included randomized control trials or quasi‐experimental studies that measured the effectiveness of interventions targeting young people aged 10–19 years or their parents and developed in a school setting. Interventions aimed at young people with intellectual disabilities, learning difficulties, or any disease requiring a specific intervention were excluded.ResultsThe search ultimately yielded 27 studies covering a total of 18 digital interventions that demonstrated positive effects, not maintained over time, on knowledge, attitudes, and behaviors, although the latter to a lesser extent.DiscussionWe have found very interesting digital interventions with effects, among others, on knowledge, attitudes, and contraceptive use in adolescents. In general, digital interventions have positive effects on knowledge and attitudes, but it is more difficult to modify behaviors with strictly digital interventions or combined with complementary face‐to‐face sessions or group class activities.ConclusionWe thus believe that digital interventions are adequate to reduce adolescent sexual risk behaviors, and our systematic review facilitates the implementation of these interventions by sharing existing digital interventions that have had positive effects, as well as the main characteristics a digital intervention should possess to reduce sexually risky behaviors in adolescents.Clinical relevanceDigital interventions with adolescents improve sexual behaviors and can be a valuable resource in education on this topic due to their accessibility and confidentiality, two key points for young people.
A multi‐nudge‐based behavioural insight into ward nurses' respiratory rate measurement: An observational study
Authors: Takaki Shunsuke , Hara Koji , Motoyama Ayana , Kawana Yuki , Kuroki Makoto , Sasaki Shusaku 
Published: August 2024

AbstractAimThis study observed changes in respiratory rate measurement (RRM) and identified barriers and challenges in clinical practice that influence healthcare worker behaviour, aiming to improve RRM in a hospital setting.DesignAn observational study was conducted.MethodsWe observed and analysed changes in the behaviour of healthcare workers at a hospital where multi‐nudges were introduced to improve RRM.ResultsWe checked respiration rate using electronic data and discovered that the original measurement rates were low. Measurement rates rapidly increased after posters were added. Barriers such as time constraints and measurement equipment were also noted.ConclusionRRM was found to be effective in promoting behavioural economics in medical settings. The results show that incorporating behavioural science principles into medical interventions has the potential to positively change behaviour.Implications for the Profession and/or Patient CareBy increasing nurses' awareness of respiratory rate measurement and addressing barriers to it, the measurement rate of respiratory rate can also increase, leading to more accurate patient evaluations and triage.ImpactWhat problem did the study address?The proportion of respiratory rate measurements leading to rapid response system (RRS) calls was low.What were the main findings?The study observed that a multi‐nudge approach effectively changes the behaviour of ward nurses, resulting in enhanced quality of medical care.Where and on whom will the research have an impact?This research can serve as a valuable reference for leaders promoting healthcare quality projects, by offering a method to encourage behavioural change.Reporting MethodThis study complied with the EQUATOR guidelines and its reporting adheres to the STROBE checklist.Patient or Public ContributionNo patient or public contribution.
Business News and Business Cycles
Authors: BYBEE LELAND , KELLY BRYAN , MANELA ASAF , XIU DACHENG 
Published: August 2024

ABSTRACTWe propose an approach to measuring the state of the economy via textual analysis of business news. From the full text of 800,000 Wall Street Journal articles for 1984 to 2017, we estimate a topic model that summarizes business news into interpretable topical themes and quantifies the proportion of news attention allocated to each theme over time. News attention closely tracks a wide range of economic activities and can forecast aggregate stock market returns. A text‐augmented vector autoregression demonstrates the large incremental role of news text in forecasting macroeconomic dynamics. We retrieve the narratives that underlie these improvements in market and business cycle forecasts.
Examining dental providers counseling on human papillomavirus vaccine: Insights from parents and dental professionals
Authors: Barrientos Luis , Shortall Sarah , Williams Joshua , Hamilton Scott , Jack Jessica 
Published: August 2024

AbstractObjectivesTo (1) assess perceptions of parents of patients ages 9–17 years regarding human papillomavirus (HPV) vaccine counseling and a same‐day HPV vaccine program, and (2) assess perceptions among dental staff who actively participated in the same administration program.MethodsWe conducted a post‐evaluation, convenience survey of parents of patients aged 9–17 and dental staff at a large‐urban federally qualified healthcare center (FQHC) from July 25, 2022, to August 26, 2022. Parent and staff perceptions were assessed using validated instruments whenever possible. Data were analyzed descriptively.ResultsOverall, 101 parents participated (response rate: 89%). Overall, 80 parents (74.3%) reported wanting to discuss diseases prevented by the HPV vaccine with their dental provider. Twenty parents (20%) reported receiving counseling on the HPV vaccine by their dentist; 95% (n = 19) of those parents reported it did not change their comfort with their provider and 60% (n = 12) reported their child received the vaccine that day.Overall, 44 dental staff members (32% DDS/DMD, 14% RDH‐BS‐Dental Hygiene, 55% Other) completed surveys (response rate: 100%). Of these, 39 (88.6%) were willing to recommend the HPV vaccine and participate in a referral program. Nearly all dentists and hygienists (95%) reported discussing the vaccine was within their scope of practice, and most (65%) agreed vaccine administration should be within their scope.ConclusionIn a single site convenience survey within an urban, federally qualified health care system, most parents, and dental staff perceived HPV vaccine counseling and administration favorably and clinically appropriate during routine dental visits.
Relationship Between Melatonin Receptor Agonists and Parkinson's Disease
Authors: Noguchi Yoshihiro , Masuda Rikuto , Aizawa Haruka , Yoshimura Tomoaki 
Published: August 2024

AbstractParkinson's disease affects millions of people worldwide, and without significant progress in disease prevention and treatment, its incidence and prevalence could increase by more than 30% by 2030. Researchers have focused on targeting sleep and the circadian system as a novel treatment strategy for Parkinson's disease. This study investigated the association between melatonin receptor agonists and Parkinson's disease, using the Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS). The target drugs were melatonin receptor agonists including ramelteon, tasimelteon, and agomelatine. Parkinson's disease cases were defined according to the Medical Dictionary for Regulatory Activities (MedDRA) 25.0; Standardized MedDRA Query (SMQ) using both the “narrow” and “broad” preferred terms (PTs) associated with Parkinson's disease. The association between melatonin receptor agonists (ramelteon, tasimelteon, and agomelatine) and Parkinson's disease was evaluated by the reporting odds ratio. Upon analyzing the data from all patients registered in the FAERS, ramelteon (ROR: 0.66, 95% confidence interval [95% CI]: 0.51–0.84) and tasimelteon (ROR: 0.49, 95% CI: 0.38–0.62) showed negative correlations with Parkinson's disease. Conversely, only agomelatine was positively correlated with Parkinson's disease (ROR: 2.63, 95% CI: 2.04–3.40). These results suggest that among the melatonin receptor agonists, ramelteon and tasimelteon are negatively correlated with Parkinson's disease. In contrast, agomelatine was shown to be positively correlated with Parkinson's disease. These results should be used in research to develop drugs for the treatment of Parkinson's disease, fully considering the limitations of the spontaneous reporting system.
Development of a Japanese Version of the Creative Mindset Scale (CMS) Using Item Response Theory
Authors: Ishiguro Chiaki , Matsumoto Kazuki , Agata Takumitsu , Noguchi Hiroyuki , Okada Takeshi 
Published: August 2024

AbstractThe purpose of this study was to develop the Japanese version of the Creative Mindset Scale (CMS‐J) and examine its psychometric properties using classical test theory (CTT) and item response theory (IRT). Three surveys were conducted to examine the psychometric properties. Study 1 (n = 700) confirmed the conceptual structure of the CMS‐J. Confirmatory factor analyses of the CMS‐J suggested a two‐factor structure, as in the original scale. The test–retest reliability was examined based on data from 143 participants who responded to the CMS‐J questionnaire after a 7‐week interval. Study 2 (n = 1,114) confirmed the convergent and discriminant validities, as well as the internal consistency, of the CMS‐J. Finally, Study 3 (n = 1,300) confirmed the effective measurement of growth and fixed mindset of the CMS‐J using IRT analyses. The present findings suggest that the CMS‐J has a fundamental psychometric property.