bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of ankle Kinesio taping on knee and ankle joint biomechanics during unanticipated jumps in collegiate athletes
Authors: Liu Quan , Wang Ling , Dai Fan , Wang Guanglan , Chen Peng 
Published: August 2024

ObjectiveMost biomechanical research on the application of Kinesio taping (KT) to the ankle joint focused on testing anticipated movements. However, ankle sprains frequently occur in real life in unanticipated situations, where individuals are unprepared and face sudden external stimuli. This situation is completely different from the anticipated situation. The aim of the present study was to investigate the effects of ankle KT application on the kinematic and kinetic characteristics of the knee and ankle joints during unanticipated jump tasks in collegiate athletes.MethodsEighteen healthy collegiate athletes experienced three taping conditions in a randomized order: no taping (NT), placebo taping (PT), and KT, and performed unanticipated jump tasks. A 9-camera infrared high-speed motion capture system was employed to collect knee and ankle kinematic data, and a 3-dimensional force plate was utilized to collect knee and ankle kinetic data during the tasks.ResultsDuring the right jumps, KT significantly increased peak knee flexion angle (P= 0.031) compared to NT and significantly decreased peak vertical ground reaction force (P< 0.001,P= 0.001) compared to NT and PT. During the left jumps, KT significantly reduced peak ankle inversion angle (P= 0.022,P< 0.001) and peak ankle inversion moment (P= 0.002,P= 0.001) compared to NT and PT.ConclusionDuring unanticipated jump maneuvers, KT reduced peak ankle inversion angle, peak vertical ground reaction force, and peak ankle inversion moment and increased peak knee flexion angle in collegiate athletes.
Brace compliance process in adolescents with spinal deformities: A qualitative study
Authors: Ghorbani Faezeh , Kamali Mohammad , Ranjbar Hadi , Kamyab Mojtaba , Razavi Hiva , Babaee Taher 
Published: August 2024

Background
Adolescent idiopathic scoliosis affects 2–4% of adolescents aged 10–16, while Scheuermann’s kyphosis affects 0.4–10% of adolescents aged 11 to 16. Over the past 50 years, brace treatment has been recommended as the most common non-surgical intervention for treating these spinal deformities. The effectiveness of brace treatment depends on the duration of brace wearing. This study aimed to understand the brace compliance process for adolescents with spinal deformities through a qualitative approach.

Method
This study applied multicenter exploratory qualitative research with an interpretative framework and enlisted the participation of as many individuals as possible involved in brace-wearing in adolescents with spinal deformities. Semi-structured, in-depth, and face-to-face interviews and telephone conversations from September 2020 to May 2021 were conducted. The recorded audio of each interview was typed into Word software with each personal code. The content analysis method was used to analyze the data.

Results
Seventy-four participants were interviewed, including 32 adolescents treated with braces and their parents (27 mothers, five fathers), six orthotists, two physiotherapists, and two spine surgeons. Following data analysis, four main categories, 14 categories, and 69 subcategories of 2403 related codes were discovered.

Conclusion
Based on the analysis of the current qualitative research, adolescents with spinal deformities experience extensive challenges in the treatment process, which can affect the results and brace intervention efficacy. The current research findings showed that every adolescent goes through similar but unique conditions during the treatment. The importance of considering each adolescent’s specific conditions and characteristics and providing functional solutions and support was understood to help them navigate critical situations more quickly and achieve effective treatment outcomes.
The skin microbiota of preterm infants and impact of diaper change frequency
Authors: Younge Noelle E. , Parris D. Joshua , Hatch Daniel , Barnes Angel , Brandon Debra H. 
Published: August 2024

Objective
To evaluate the impact of diaper change frequency, clinical characteristics, and skin health metrics on development of the skin microbiota in preterm infants.

Design
A randomized controlled parallel design was used.

Methods
Medically stable preterm infants born <33 weeks’ gestation were randomized to receive diaper changes at a frequency of every 3-hours or every 6-hours. Skin swabs were collected longitudinally from the diapered skin (buttocks) and chest. Skin pH and transepidermal water loss were measured with each sample collection. Stool samples were collected from the diaper. The microbiome at each site was characterized by 16S rRNA gene sequencing. Associations between microbiome features, diaper change frequency, and other covariates were examined using mixed effect models and redundancy analysis.

Results
A total of 1179 samples were collected from 46 preterm infants, beginning at a median postnatal age of 44 days and continuing through hospital discharge. Alpha-diversity of the skin microbiota increased over time, but did not differ significantly between 3-hour (n = 20) and 6-hour (n = 26) diaper change groups. Alpha-diversity of the skin microbiota was inversely correlated with skin pH, but not transepidermal water loss. Microbiota community structure differed significantly between body sites (buttocks, chest, and stool) and between individuals. Among samples collected from the diapered skin, diaper change frequency, infant diet, antibiotic exposure, and delivery mode accounted for minor proportions of the variation in microbiota community structure between samples. Relative abundances of multiple genera differed between 3- and 6-hour diaper change groups over time.

Discussion/Conclusion
The diversity and composition of the diapered skin microbiota is dynamic over time and differs from other body sites. Multiple factors including interindividual effects, diaper change frequency, diet, and antibiotics contribute to variation in the diapered skin microbiota.
Changes in unmet need for family planning among married women of reproductive age in Nigeria: A multilevel analysis of a ten-year DHS wave
Authors: Oyinlola Funmilola Folasade , Kupoluyi Joseph Ayodeji , Adetutu Olufemi Mayowa 
Published: August 2024

Introduction
Unmet need for family planning [UNFP] remains a serious public health concern in Nigeria. Evidence suggests that UNFP remains high over the last fifteen years despite numerous policies and programmes aimed at generating demand for family planning. This study used three Demographic and Health Survey (DHS) conducted over a ten-year period (2008–2018) to assess the changes in unmet need for family planning and associated contextual determinants. Understanding changes in unmet need for family planning among women and its associated contextual factors is crucial for designing appropriate interventions.

Methods
We analysed datasets the Nigeria Demographic and Health Surveys of 2008, 2013 and 2018 to assess changes and contextual determinants of unmet need for family planning. Data were analysed using frequency distribution, chi-square statistical test and multilevel binary logistic regression models. Due to the hierarchical structure of the data in which individuals are nested within households, multilevel mixed-effect logistic regression models were constructed. We used a multilevel binary logistic regression model after adjusting for variables not significant at the bivariate level. An adjusted odds ratio with 95% confidence interval was reported, with a p-value less than 0.05 declared to be significant predictors of unmet need for family planning.

Results
Unmet need for family planning decreased from 20.21% to 16.10% between 2008 and 2013 but subsequently rose later from 16.10% to 18.89% between 2013 and 2018. The pattern of changes in unmet need for either limiting or spacing was consistently high over the 10-year period, with the highest rate of each of the indicators of unmet need for family planning occurring in 2018 while the lowest rate was in 2008, thus indicating an increase in the proportion of respondents having unmet need for family planning over the referenced period. Age of respondents, educational level, wealth status, religious affiliation, parity, sex of head of household, partner educational level, region of residence, and community socioeconomic status were significant factors associated with the unmet need for family planning across the different data waves in Nigeria (p < 0.05). An intraclass correlation (ICC) of 4.9% showed that the individual and household level factors had a greater influence on the variation in the unmet need for family planning than did community factors in Nigeria.

Conclusion
The overall prevalence of unmet need for family planning was consistently high over the ten-year period and community-level factors had lowest influence on the variation in unmet need for family planning compared to household and individual-level factors in Nigeria. Policies and interventions should focus on improving women’s socio-economic and demographic characteristics at individual, household, and community levels to improve unmet need for family planning.
Films of Arab Loutfi and Heiny Srour: Studies in Palestine Solidarity Cinema, Terri Ginsberg (2021)
Authors: Broe Dennis 
Published: August 2024

Review of: Films of Arab Loutfi and Heiny Srour: Studies in Palestine Solidarity Cinema, Terri Ginsberg (2021)
Cham: Palgrave Pivot, xii + 107 pp.,
ISBN-13 978-3-03085-353-2, h/bk, USD 49.99
ISBN-13 978-3-03085-354-9, e-book, USD 64.99
Bone microarchitecture and fracture risk in rheumatoid arthritis
Authors: Kozyreva M. V. , Demin N. V. , Dobrovolskaya O. V. , Nikitinskaya O. A. , Toroptsova N. V. 
Published: August 2024

BACKGROUND: Microarchitecture of trabecular bone tissue can currently be evaluated using a special program for dual-energy X-ray absorptiometry (DXA) to determine the trabecular bone score (TBS). AIM: to assess bone microarchitecture and fracture risk in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: a cross — sectional study included 95 postmenopausal women with confirmed diagnosis of RA (mean age 62.3 ± 8.1 years). The survey was conducted using a specially designed questionnaire, laboratory examination, DXA of the lumbar spine (L1–L4) with the determined of TBS and proximal femur. The risk of major osteoporotic fractures (MOF) was assessed using FRAX calculator without or with TBS standardization. RESULTS: 41 (43.2 %) patients had osteoporosis (OP) in at least one measurement area, while in L1–L4 — 26.3 %, in the femoral neck (FN) — 22.1 % and in total hip (TH) — 11.6 % persons. 35.8 % women had normal, 25.3 % — partially degraded and 38.9 % — degraded microarchitecture according to TBS. In patients with a history of fractures, low TBS was detected significantly more often than in people without fractures (p < 0.05). TBS was negatively correlated with age with age (r = -0.30, p = 0.003), duration of postmenopause (r = -0.26, p = 0.014), cumulative dose of glucocorticoids (GCs) (r = -0.34, p = 0.045) and positively correlated with BMD L1-L4 (r = 0.43, p < 0.001), BMD of the FN (r = 0.21, p = 0.038) and BMD TH (r = 0.23, p = 0.02). Normal BMD values in L1–L4 and at the same time degraded microarchitecture according to TBS were in 9.5 % RA persons. A high risk of fractures according to FRAX was detected in 47 (49.5 %) women, and FRAX adjusted for TBS increased the number of such patients to 52 (54.7 %). CONCLUSION: OP was diagnosed in 43.2 % of postmenopausal women with confirmed RA, and 38.9 % had degraded bone microarchitecture by TBS. Negative associations were found between TBS and age, duration of postmenopause, cumulative dose of GCs, and positive associations with BMD in all parts of the skeleton. Including TBS values into the FRAX calculator made it possible to redistribute patients into risk groups, as a result of which 54.7 % of patients had a high risk of MOF.
Development and validation of a stability indicating UPLC-DAD method coupled with MS-TQD for ramipril and thymoquinone in bioactive SNEDDS with in silico toxicity analysis of ramipril degradation products
Authors: Elzayat Ehab M. , Sherif Abdelrahman Y. , Shahba Ahmad Abdul-Wahhab , Kazi Mohsin , Alyahya Mohammed , Darwish Hany W. 
Published: August 2024

Abstract
The identification of degradation products of therapeutic molecules in pharmaceutical formulations has gained significant attention due to their potential impact on patient safety. Ramipril (RP), an antihypertensive agent, was incorporated into a self-nanoemulsifying drug delivery system (SNEDDS), which greatly enhanced its bioavailability. However, none of the previous studies have investigated the toxicological effects of these degradation products that may form during storage. Moreover, a bioactive SNEDDS containing black cumin oil (BCO) and its bioactive ingredient, thymoquinone (TQ), was used to further enhance the therapeutic activity of RP. To assess the stability of the proposed formulation, a validated ultrahigh-performance liquid chromatography (UPLC) method was developed to simultaneously measure the concentrations of RP and TQ. The formulation was subjected to accelerated stress conditions to facilitate drug degradation. The resulting degradation products were analyzed using mass spectroscopy (MS) to determine their molecular mass, and their chemical structures were in silico predicted using Zeneth Nexus software, while their toxicity was assessed using in silico Derek Nexus software. RP and TQ, along with their degradation products, were separated using an HSS T3 column at a flow rate of 0.25 mL/min. The detection wavelengths for RP and TQ were 210 and 254 nm, respectively. The developed UPLC method exhibited acceptable linearity for both RP and TQ, with correlation coefficient (r
2) values exceeding 0.9995 and 0.9998, respectively. The method provided accurate, precise, and high-resolution analysis of both drugs and their degradation products within a short run time of less than 3.2 min. The toxicity and mutagenicity of two alkaline degradation products of RP were predicted using in silico software Derek Nexus (version 6.3). Several toxicity endpoints, including chromosomal damage, skin sensitization, and hepatotoxicity, were predicted. Overall, the developed method can be used to evaluate the stability and integrity of RP and TQ during the development of the proposed antihypertensive formulation.
Oligometastatic disease – a renaissance for surgery?
Authors: Goetze Thorsten , Chevallay Mickael , Dosch Michel , Marcelis Jordan , Al-Batran Salah-Eddin , Mönig Stefan Paul 
Published: August 2024

Abstract
Half of the patients with esophageal cancer, cancer of the gastro-esophageal junction and gastric cancer present metastasis at the time of diagnosis. In addition, even patients originally thought to be free of metastasis will present metachronous metastasis in the course of the disease. These patients are considered incurable and current standard of care for metastatic esophageal, gastro-esophageal junction and gastric cancers is a systemic therapy without curative intention. However, patients presenting only a low metastatic load are now defined as oligometastatic disease and should benefit from an aggressive, multimodal therapy. We present here a review of recent publications investigating multimodal therapies for oligometastatic disease and showing that a systemic therapy combined with a resection of the primary tumor together with metastasis is associated with a better prognosis than a systemic therapy alone. We also give a precise focus on esophageal squamous cell carcinomas and adenocarcinomas of the gastro-esophageal junction and of the stomach. Interestingly, patients with oligometastatic cancer of the esophago-gastric junction can even be treated in curative intention with such a multimodal therapy as we present here in a short case report. In conclusion, new therapeutic strategies including multimodal approaches for oligometastatic disease have shown promising results in the last years and ongoing randomized prospective trials will provide us the evidence to include them in future European guidelines.
Recurrence relations for the joint distribution of the sum and maximum of independent random variables
Authors: Efrem Christos N. 
Published: August 2024

Abstract
In this paper, the joint distribution of the sum and maximum of independent, not necessarily identically distributed, nonnegative random variables is studied for two cases: (i) continuous and (ii) discrete random variables. First, a recursive formula of the joint cumulative distribution function (CDF) is derived in both cases. Then recurrence relations of the joint probability density function (PDF) and the joint probability mass function (PMF) are given in the former and the latter case, respectively. Interestingly, there is a fundamental difference between the joint PDF and PMF. The proofs are simple and mainly based on the following tools from calculus and discrete mathematics: differentiation under the integral sign (also known as Leibniz’s integral rule), the law of total probability, and mathematical induction. In addition, this work generalizes previous results in the literature, and finally presents several extensions of the methodology.
Language attitudes in the mass media: What attitude towards the Ukrainian language was formed by the Odesa media (2014–2023)
Authors: Kuznietsova Tetiana 
Published: August 2024

Summary
The article examines the issue of the representation of language attitudes in mass media texts. The focus is on the attitude towards the Ukrainian language manifested in the texts of Odesa online publications during 2014–2023. Content analysis of the popular internet publications of Odesa has been chosen as the main method of research. We focused on mass media materials that mentioned the concepts of “The Ukrainian language” and “The Russian language”. More than 700 media texts were analyzed in total. The research enabled us to identify the main models of attitudes towards the Ukrainian language in the analyzed media through the dichotomy of ‘ours – theirs’, which changed both in intensity and content. Conditionally, we can identify the date of the change in this dichotomy as the beginning of the large-scale invasion of Russia into Ukraine. During 2014–2021, a trend of ambivalent attitudes. After February 24, 2022, the language-based dichotomy ‘ours – theirs’ has changed its expressive power and clearly fixed its objects: as a rule, the Ukrainian language has become ‘ours’, whilst Russian – ‘theirs’. This, in its turn, has led to the displacement of negative evaluation rhetoric regarding the Ukrainian language in all the analyzed media. It was due to the political situation in the country and the change in many values of Ukrainians during the war.
Stem Cell Therapy for SARS-CoV-2 and Influenza Virus Infections
Authors: Datta Neelabh 
Published: August 2024

Abstract
The emergence of infectious diseases, including viral zoonoses, has allowed intensive research into novel therapeutic approaches. Stem cell therapy, mostly using mesenchymal stem cells (MSCs), has garnered significant attention due to the immunomodulatory properties and tissue repair capabilities. MSCs have demonstrated promise in treating severe COVID-19 cases and several clinical trials have revealed that MSC therapy improves 28-day survival rates, reduces mortality, and accelerates recovery. These cells effectively mitigate a cytokine storm, relieve pulmonary symptoms, and positively influence organ recovery, including the liver and kidneys. Bioanalytical readings return to normal following MSC administration, emphasizing the potential in managing COVID-19-induced complications. MSC therapy offers a potential solution for infection with the influenza virus, which is responsible for historical pandemics and epidemics, and remains a global health concern. MSCs inhibit immune cell-mediated responses and reduce lung damage in animal models, and despite antiviral drugs, influenza-induced manifestations persist. MSCs, with an ability to counteract inflammation and promote lung tissue repair, hold promise for managing influenza infections. While MSCs offer therapeutic benefits, certain challenges remain. Specifically, ethical considerations, regulatory hurdles, and scalability are some of the challenges that hinder widespread adoption. However, ongoing systematic reviews and meta-analyses provide real-time insight that support the security and effectiveness of MSC therapy.
Sketching Musical Meaning? Case Studies from Ligeti’s Late Works
Authors: Donaldson James 
Published: August 2024

This article explores how a composer’s working materials can contribute to the analysis of musical meaning. Using examples of Ligeti’s sketches for his late works, I demonstrate how they can support familiar interpretations as well as catalyzing novel understandings. In particular, Ligeti’s prose notes, or “jottings” provide a jumping off point for hermeneutic analysis. Although the sheer amount of information provided in the jottings can be paralyzing, I explore how the material can nevertheless, when used cautiously, contribute insights.
I draw upon Foucault’s distinction between author-function and historical figure to frame two possible roles for the sketch materials. In my first two case studies, I frame the sketches as reflecting the author-function by amplifying a grotesque aesthetic associated with Ligeti’s late works. Examining manipulations of a hunt topic in the sketches for the Hamburg Concerto and of a specific Hungarian folk melody across the two versions of the Violin Concerto, I show how the composer consciously distorted conventional musical topics to produce a distanced or ironic effect. In my third and fourth case studies, I explore the sketches as records of the historical figure of Ligeti. I outline two problematic cases in which his preliminary notes or jottings are at odds with his public pronouncements: the opening of “Spectra” from Ligeti’s Hamburg Concerto, and passages of the Piano Concerto. Tensions between sketch evidence and published remarks lead me to explore the underlying ideologies of Ligeti’s avant-garde aesthetic.
The Role of Sembung (<i>Blumea balsamifera</i>) Leaf Extract in Preventing Atherosclerosis in Hyperlipidemia Rat Models
Authors: I Made Jawi  , I Wayan Putu Sutirta Yasa  , I Gede Widhiantara  , Anak Agung Ngurah Subawa  , Putu Angga Wiradana  , Naw Sin War 
Published: August 2024

This study aims to prove that administering BBLE as a natural antioxidant can prevent atherosclerosis by maintaining lipid profiles, antioxidant enzymes, and netrin-1 levels in hyperlipidemia in rat models. The research subjects were 20 adult male Wistar rats (Rattus norvegicus), which were divided into 2 groups using a randomized pretest and posttest control group design. Before treatment and after treatment for 3 months, lipid profiles, MDA, SOD, and netrin-1 were examined. The control group was only given high-cholesterol diets (HCD), while the treatment, apart from HCD, was also given BBLE 4mg/day. The data obtained was tested using paired t-test and group t-test. The results of the study showed that there was a significant decrease in netrin-1 in the control group (p<0.05) after being given HCD for three months. In the treatment group, it also decreased but it was not significant (p>0.05). Netrin-1 levels in the treatment group were higher than the control (p<0.05). The lipid profile experienced a significant increase in HDL in the treatment group accompanied by a significant decrease in MDA and an increase in SOD (p<0.05) when compared with the control group. This study concludes that administering BBLE at a dose of 4 mg/day to rats given HCD caused an increase in netrin-1 levels accompanied by improvements in lipid profiles and prevention of oxidative stress. The findings of this study reveal the novelty of BBLE in treating and maintaining blood vessel function in mice given HCD by increasing netrin-1 levels.