bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional MR cholangiography of the cystic duct and sphincter of Oddi using gadoxetate disodium: Is a 30‐minute delay long enough?
Authors: Corwin Michael T. , Lamba Ramit , McGahan John P. 
Published: September 2012

AbstractPurpose:To determine if excreted contrast is consistently visualized in the gallbladder and duodenum after a 30‐minute delay using gadoxetate disodium‐enhanced MRI in patients without hepatobiliary disease.Materials and Methods:Twenty‐two patients without evidence of liver or biliary disease underwent gadoxetate disodium‐enhanced magnetic resonance imaging (MRI) from February 17, 2009 through October 3, 2011. The mean age was 45 years (range 25–72). T1‐weighted hepatobiliary phase images at 5, 10, 20, and 30 minutes after contrast injection were reviewed in consensus by two radiologists to determine the delay at which enhancement of the gallbladder and duodenum first occurred.Results:Thirteen of 22 (59.1%) patients demonstrated duodenal filling by 20 minutes and 16/22 (72.7%) filled by 30 minutes. The mean time to duodenal enhancement was 19.9 minutes (range 11.4–30.2 min). Seventeen of 22 (77.3%) patients demonstrated gallbladder filling by 20 minutes and 21/22 (95.5%) filled by 30 minutes. The mean time to gallbladder enhancement was 16.5 minutes (range 4.4–30.2 min).Conclusion:A significant number of normal patients do not show duodenal filling by 30 minutes, while the majority fill the gallbladder by 30 minutes using functional MR cholangiography (fMRC) with gadoxetate disodium. These findings will guide fMRC protocol design for patients with suspected acute cholecystitis and sphincter of Oddi dysfunction. J. Magn. Reson. Imaging 2013;37:993–998. © 2012 Wiley Periodicals, Inc.
Measuring the longitudinal relaxation time of GABA in vivo at 3 tesla
Authors: Puts Nicolaas A.J. , Barker Peter B. , Edden Richard A.E. 
Published: September 2012

AbstractPurpose:To measure the in vivo longitudinal relaxation time T1 of GABA at 3 Tesla (T).Materials and Methods:J‐difference edited single‐voxel MR spectroscopy was used to isolate γ‐aminobutyric acid (GABA) signals. An increased echo time (80 ms) acquisition was used, accommodating the longer, more selective editing pulses required for symmetric editing‐based suppression of co‐edited macromolecular signal. Acquiring edited GABA measurements at a range of relaxation times in 10 healthy participants, a saturation‐recovery equation was used to model the integrated data.Results:The longitudinal relaxation time of GABA was measured as T1,GABA = 1.31 ± 0.16 s.Conclusion:The method described has been successfully applied to measure the T1 of GABA in vivo at 3T. J. Magn. Reson. Imaging 2013;37:999–1003. © 2012 Wiley Periodicals, Inc.
Affinity of protein fibres towards sulfation
Authors: Taddei Paola , Tsukada Masuhiro , Freddi Giuliano 
Published: September 2012

Wool, Bombyx mori and Antheraea pernyi (Tussah) silk fibres were treated with chlorosulfonic acid in pyridine and investigated by FT‐IR and FT‐Raman spectroscopies as well as mechanical measurements. The reactivity towards sulfation was found to decrease along the series: wool > Bombyx mori silk fibroin > Tussah silk fibroin, in agreement with weight gain which decreased along the same series. Accordingly, Tussah silk maintained its intrinsic tensile properties essentially unchanged upon the treatment, while for Bombyx mori silk fibroin, the tensile performance decreased sharply especially at longer reaction times. Sulfated wool was characterized by an increased fibre extensibility.New IR and Raman bands attributable to various vibrations of sulfated groups were detected in sulfated wool and to a lower extent in Bombyx mori silk fibroin fibres; all the fibres underwent conformational rearrangements upon sulfation, independent of the sulfation yield. Wool fibres treated with chlorosulfonic acid in pyridine bound considerable amounts of sulfate mainly through the hydroxyl groups of serine, threonine and tyrosine. Also, tryptophan and basic amino acids were found to participate to the reaction. B. mori silk fibroin fibres appeared to bind a minor amount of sulfate groups mainly trough the hydroxyl groups of Ser.Weight gain, spectroscopic and mechanical data are discussed in relation to the difference in fibre morphology, structure and crystallinity, as well as to the amount and accessibility of potentially reactive amino acids. Copyright © 2012 John Wiley & Sons, Ltd.
Low‐level laser therapy (808 nm) reduces inflammatory response and oxidative stress in rat tibialis anterior muscle after cryolesion
Authors: Assis Lívia , Moretti Ana I.S. , Abrahão Thalita B. , Cury Vivian , Souza Heraldo P. , Hamblin Michael R. , Parizotto Nivaldo A. 
Published: September 2012

AbstractBackground and ObjectiveMuscle regeneration is a complex phenomenon, involving coordinated activation of several cellular responses. During this process, oxidative stress and consequent tissue damage occur with a severity that may depend on the intensity and duration of the inflammatory response. Among the therapeutic approaches to attenuate inflammation and increase tissue repair, low‐level laser therapy (LLLT) may be a safe and effective clinical procedure. The aim of this study was to evaluate the effects of LLLT on oxidative/nitrative stress and inflammatory mediators produced during a cryolesion of the tibialis anterior (TA) muscle in rats.Material and MethodsSixty Wistar rats were randomly divided into three groups (n = 20): control (BC), injured TA muscle without LLLT (IC), injured TA muscle submitted to LLLT (IRI). The injured region was irradiated daily for 4 consecutive days, starting immediately after the lesion using a AlGaAs laser (continuous wave, 808 nm, tip area of 0.00785 cm2, power 30 mW, application time 47 seconds, fluence 180 J/cm2; 3.8 mW/cm2; and total energy 1.4 J). The animals were sacrificed on the fourth day after injury.ResultsLLLT reduced oxidative and nitrative stress in injured muscle, decreased lipid peroxidation, nitrotyrosine formation and NO production, probably due to reduction in iNOS protein expression. Moreover, LLLT increased SOD gene expression, and decreased the inflammatory response as measured by gene expression of NF‐kβ and COX‐2 and by TNF‐α and IL‐1β concentration.ConclusionThese results suggest that LLLT could be an effective therapeutic approach to modulate oxidative and nitrative stress and to reduce inflammation in injured muscle. Lasers Surg. Med. 44: 726–735, 2012. © 2012 Wiley Periodicals, Inc.
Selenium/Tellurium‐Containing Hyperbranched Polymers: Effect of Molecular Weight and Degree of Branching on Glutathione Peroxidase‐Like Activity
Authors: Thomas Joice , Dong Zeyuan , Dehaen Wim , Smet Mario 
Published: September 2012

AbstractA series of novel hyperbranched polyselenides and polytellurides with multiple catalytic sites at the branching units has been synthesized via the polycondensation of A2 + B3 monomers. The GPx‐like activities of these polymer mimics were assessed and it was found that the polytellurides showed higher GPx‐like activities than the corresponding polyselenides. Interestingly, the polymers with higher molecular weights and degree of branching (DB) showed higher GPx‐like activities than the analogous lower molecular weight polymer. The enhancement in the catalytical activity of the hyperbranched polymers with increasing molecular weight affirmed the importance of the incorporation of multiple catalytic groups in the macromolecule which increases the local concentration of catalytic sites.
Association of the miR‐146aC>G, miR‐149T>C, miR‐196a2T>C, and miR‐499A>G polymorphisms with gastric cancer risk and survival in the korean population
Authors: Ahn Dae Ho , Rah HyungChul , Choi Young‐Kook , Jeon Young Joo , Min Kyung Tae , Kwack KyuBum , Hong Sung Pyo , Hwang Seong Gyu , Kim Nam Keun 
Published: September 2012

AbstractWe investigated whether four common microRNA polymorphisms (miR‐146aC>G [rs2910164], miR‐149T>C [rs2292832], miR‐196a2T>C [rs11614913], and miR‐499A>G [rs3746444]) are associated with the susceptibility and prognosis of gastric cancer in the Korean population. The four microRNA single‐nucleotide polymorphisms (SNPs) were identified in a case–control study (461 patients; 447 controls) by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) analysis in the Korean population. When patients were stratified into diffuse and intestinal‐type gastric cancer groups, subjects with the miR‐499AG and AG + GG genotypes had reduced adjusted odds ratios (AORs) for diffuse‐type gastric cancer (AOR = 0.54 with 95% confidence interval [CI] = 0.31–0.97; AOR = 0.57 with 95% CI = 0.33–0.97). In the stratified analyses for gastric cancer risk, the miR‐146aGG and CG + GG genotypes were associated with increased risk of gastric cancers among the non‐smokers, whereas the miR‐149TC and TC + CC genotypes showed lower risk of gastric cancer in males. The miR‐196a2CC genotype was associated with elevated gastric cancer risk among females. For gastric cancer prognosis, intestinal‐type gastric cancer patients with miR‐146aCG + GG genotypes had significantly higher survival rates (log‐rank P = 0.030) than patients with the CC genotype, and patients with the miR‐499AA genotype had significantly increased survival rates compared to patients with the AG + GG genotypes (log‐rank P = 0.013). When miR‐146aCG + GG and miR‐499AA genotypes were combined, the survival rate of intestinal‐type gastric cancer patients was elevated (log‐rank P < 0.001). No association was found between gastric or diffuse‐type cancer prognosis and other miRNAs. Our data demonstrate that specific miRNA SNPs are associated with gastric cancer susceptibility (miR‐499A>G) and prognosis (miR‐146aC>G and miR‐499A>G) in the Korean population depending on gastric cancer type. © 2012 Wiley Periodicals, Inc.
Use of patient reported outcome questionnaires in the urogynecologic literature
Authors: Treszezamsky Alejandro D. , Ehsani Nazanin , Connell Roxanne , Dick‐Biascoechea Madeline , Fashokun Tola 
Published: September 2012

AbstractAimsWe aimed to describe the current use of patient reported outcome questionnaires (PROQ) in the urogynecologic literature.MethodsAll articles from 2009 in 11 journals were reviewed and included if PROQ were used. PROQ were assigned the grades of recommendation used by the International Consultation on Incontinence (ICI). Data were collected by two independent reviewers (differences resolved by consensus). Fisher and χ2 tests were used for statistics.ResultsOf the 212 articles included, 126 used multiple PROQ. Seventy‐two percent used at least one grade A PROQ and 42% exclusively used grade A PROQ. Articles about urinary incontinence (UI) were more likely to use grade A PROQ than those pertaining to interstitial cystitis or anal incontinence. Eighty‐three articles used PROQ in non‐English languages. These articles were as likely to use ICI grade A PROQ as those using English PROQ. When translated questionnaires are used, 41.5% of articles did not provide references for a validation of the translated version. Eighty‐seven different PROQ were identified and used 422 times. Of those, 75 were developed in English. Short versions were used more frequently. PROQ available online were used 9.4 times more frequently than those requiring payment. The more utilized PROQ were more often grade A than those rarely used (P < 0.001).ConclusionsUsing multiple PROQ is common in the literature reviewed. 72.2% of articles used at least one PROQ with the highest ICI recommendation but only 42% used exclusively those. Short and easily available PROQ were used more often. Most PROQ are developed in English. Neurourol. Urodynam. 32: 336–340, 2013. © 2012 Wiley Periodicals, Inc.
Increased risk of depressive disorder following diagnosis with bladder pain syndrome/interstitial cystitis
Authors: Keller Joseph J. , Liu Shih‐Ping , Lin Herng‐Ching 
Published: September 2012

AbstractAimBladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic pain syndrome of unknown etiology that primarily affects women. Using a longitudinal follow‐up design, this study aimed to examine the risk of depressive disorder (DD) among women with BPS/IC compared to the general population during a 1‐year period following their diagnosis.MethodThis study used data from the Taiwan “Longitudinal Health Insurance Database.” A total of 832 patients with BPS/IC were included in the study group and 4,160 matched non‐BPS/IC enrollees were included as the comparison group. Each patient (n = 4,992) was individually tracked for a 1‐year period to identify those who subsequently received a diagnosis of DD. Cox proportional hazards regressions (stratified by age group and the index year) were used to estimate the risk of subsequent DD following a diagnosis of BPS/IC.ResultsWe found that during the 1‐year follow‐up, the incidence rate of DD was 4.69 (95% CI: 3.38–6.34) per 100 person‐years in patients with BPS/IC and 0.94 (95% CI: 0.68–1.27) per 100 person‐years in comparison patients. The hazard ratio (HR) of DD during the 1‐year follow‐up period for patients with BPS/IC was 5.06 (95% CI: 3.21–7.96, P < 0.001) that of comparison patients after adjusting for patient monthly income, geographic location, and urbanization level. The adjusted HR for DD associated with BPS/IC was 10.33 for patients aged between 40 and 49 (95% CI: 3.68–29.04).ConclusionOur study demonstrated that there is an increased risk for being diagnosed with DD during the first year subsequent to being diagnosed with IC/PBS. Neurourol. Urodynam. 32: 467–471, 2013. © 2012 Wiley Periodicals, Inc.
Immediate effects of the initial FDA notification on the use of surgical mesh for pelvic organ prolapse surgery in medicare beneficiaries
Authors: Reynolds W. Stuart , Gold Karen P. , Ni Shenghua , Kaufman Melissa R. , Dmochowski Roger R. , Penson David F. 
Published: September 2012

AbstractAimsPrompted by increased reports of complications with the use of mesh for pelvic organ prolapse (POP) surgery, the FDA issued an initial public health notification (PHN) in 2008. We proposed to determine if the numbers of POP cases augmented with surgical mesh performed in U.S. Medicare beneficiaries changed relative to this PHN.MethodsUsing administrative healthcare claims for beneficiaries enrolled in the U.S. Medicare program from 2008 to 2009, we identified women who underwent POP surgery with and without surgical mesh by procedural and diagnosis coding. In addition to comparing cases with and without mesh, we also calculated rates (number of cases per 100,000 female beneficiaries) and compared these relative to the timing of the PHN.ResultsWe identified 104,185 POP procedures, of which 27,839 (26.7%) included mesh material and 76,346 (73.3%) did not. Between the last three quarters of 2008 and the first three of 2009, the rates of mesh cases increased (40.3–42.1, P < 0.001) and those without mesh decreased (115.5–111.4, P < 0.001). Inpatient procedures decreased and outpatient procedures increased for both those with and without mesh augmentation. For inpatient procedures, the relative use of biologic graft and synthetic mesh material did not vary over the study period.ConclusionsA substantial number of Medicare beneficiaries underwent mesh POP procedures in 2008–2009. However, despite the PHN cautioning about potential mesh complications, the numbers of mesh cases continued to rise in the immediate period after the PHN. Neurourol. Urodynam. 32: 330–335, 2013. © 2012 Wiley Periodicals, Inc.
Functional roles of transient receptor potential melastatin 8 (TRPM8) channels in the cold stress‐induced detrusor overactivity pathways in conscious rats
Authors: Lei Zhang , Ishizuka Osamu , Imamura Tetsuya , Noguchi Wataru , Yamagishi Takahiro , Yokoyama Hitoshi , Kurizaki Yoshiki , Sudha Gautam Silwal , Hosoda Tomoka , Nishizawa Osamu , Andersson Karl‐Erik 
Published: September 2012

AbstractAimsWe determined if transient receptor potential melastatin 8 (TRPM8) channels are involved in the detrusor overactivity induced by menthol, or exposure to low temperature (LT).MethodsTwo days prior to cystometric investigation, the bladders of 10‐week‐old Sprague–Dawley rats were cannulated to measure bladder pressure. After a 20 min baseline cystometry period, the TRPM8 channel antagonist, N‐(4‐tert‐butylphenyl)‐4‐(3‐chloropyridin‐2‐yl)piperazine‐1‐carboxamide (BCTC), or vehicle, was administered through a jugular vein catheter (n = 6). A 90% menthol solution was sprayed onto bare leg skin once every 5 min for 20 min, and then cystometric measurements were repeated. After a 30‐min recovery period, the rats were intravenously administered 0.1 µmol/kg BCTC. Five minutes later, they were again sprayed and cystometry recorded. In separate experiments, cannulated rats were intravenously administered 0.001, 0.01, or 0.1 µmol/kg BCTC (n = 6 each dose). Five minutes later, they were exposed to LT (4 ± 2°C) for 20 min of cystometry.ResultsMenthol spray decreased voiding interval, micturition volume, and bladder capacity in the BCTC‐free rats. However after BCTC administration, these effects were prevented. Exposure to LT elicited detrusor overactivity that caused decreased voiding interval, micturition volume, and bladder capacity. However, at 0.01 and 0.1 µmol/kg, BCTC inhibited this cold stress‐induced detrusor overactivity.ConclusionsSince the TRPM8 channel agonist, BCTC, inhibited detrusor overactivity in rats sprayed with the TRPM8 channel agonist, menthol, and the drug also inhibited cold stress‐induced detrusor overactivity, we conclude that TRPM8 channels mediate, at least partially, detrusor overactivity elicited by exposure to LT. Neurourol. Urodynam. 32: 500–504, 2013. © 2012 Wiley Periodicals, Inc.
From sentinel cells to inflammatory culprits: cancer‐associated fibroblasts in tumour‐related inflammation
Authors: Servais Charlotte , Erez Neta 
Published: September 2012

AbstractInflammation is now established as a hallmark of cancer. Cancer‐associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumour cells and their microenvironment. Central to the role of CAFs in facilitating tumour growth, invasion, and metastasis is their ability to orchestrate tumour‐related inflammation. CAFs and their soluble mediators provide multiple complex regulatory signals that modulate the trafficking, differentiation status, and function of inflammatory cells in the tumour microenvironment. This review focuses on pathways by which CAFs mediate tumour‐promoting inflammation and modify the components of the inflammatory microenvironment that facilitate tumour initiation, progression, and metastasis.Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Peritoneal sarcomatosis in pediatric malignancies
Authors: Huh Winston W. , Fitzgerald Nancy E. , Mahajan Anita , Hayes‐Jordan Andrea 
Published: September 2012

AbstractPeritoneal sarcomatosis (PSC) is defined as peritoneal involvement of multiple sarcomatous tumors. Desmoplastic small round cell tumors (DSRCT) and rhabdomyosarcomas are the most common pediatric PSC cases. PSC has been treated with chemotherapy and mainly palliative surgery, but long‐term outcome has been poor. New imaging technologies have improved the evaluation of disease extent and patterns of peritoneal dissemination, and cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is being evaluated as a treatment option to prolong remission in pediatric patients. We will review the clinical characteristics, potential biologic mechanisms, radiographic characteristics, and potential therapies for pediatric PSC patients. Pediatr Blood Cancer 2013; 60: 12–17. © 2012 Wiley Periodicals, Inc.
Initial testing (stage 1) of the phosphatidylinositol 3′ kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program
Authors: Reynolds C. Patrick , Kang Min H. , Carol Hernan , Lock Richard , Gorlick Richard , Kolb E. Anders , Kurmasheva Raushan T. , Keir Stephen T. , Maris John M. , Billups Catherine A. , Houghton Peter J. , Smith Malcolm A. 
Published: September 2012

AbstractBackgroundActivation of the PI3 kinase pathway occurs frequently in many adult cancers and is implicated in tumor cell proliferation, survival, and resistance to chemotherapy and radiotherapy. However, less is known regarding the relevance of this pathway in pediatric cancers. Here we have evaluated SAR245408, a novel small molecule PI3K inhibitor, against childhood cancer cell lines and xenografts.ProceduresSAR245408 was tested against the PPTP in vitro cell line panel at concentrations from 10 to 100 µM and against the PPTP in vivo xenograft panels at a dose of 100 mg/kg administered orally daily × 14.ResultsIn vitro SAR245408 demonstrated cytotoxic activity, with a median relative IC50 value of 10.9 µM (range 2.7–24.5 µM). SAR245408 was well tolerated in vivo, and all 44 tested xenograft models were evaluable for efficacy. SAR245408 induced significant differences in EFS distribution compared to control in 29 of 37 (79%) of solid tumor xenografts and in two of seven (29%) ALL xenografts. SAR245408 induced tumor growth inhibition meeting criteria for intermediate EFS T/C activity (EFS T/C > 2) in 4 of 37 (11%) solid tumor xenografts. Intermediate EFS T/C activity was also observed for two of seven (29%) evaluable ALL xenografts. Objective responses were not observed for solid tumor or for ALL xenografts.ConclusionsUnder the conditions evaluated in this study, SAR245408 achieved modest single‐agent activity against most PPTP preclinical models. Further exploration of SAR245408 in combination with standard agents or with other signaling inhibitors could be considered. Pediatr Blood Cancer 2013; 60: 791–798. © 2012 Wiley Periodicals, Inc.
Blunted response to a growth hormone stimulation test is associated with unfavorable cardiovascular risk factor profile in childhood cancer survivors
Authors: Petryk Anna , Baker K. Scott , Frohnert Brigitte , Moran Antoinette , Chow Lisa , Sinaiko Alan R. , Steffen Lyn M. , Perkins Joanna L. , Zhang Lei , Hodges James S. , Steinberger Julia 
Published: September 2012

AbstractBackgroundChildhood cancer survivors (CCS) are at risk for growth hormone (GH) deficiency. CCS are also at increased risk for early mortality from cardiovascular (CV) disease, but the association between GH levels and CV risk remains poorly understood. The goal of this study was to examine the cross‐sectional association between stimulated GH levels and CV risk factors in CCS younger than 18 years.ProcedureA total of 276 CCS (147 males, 14.4 ± 2.6 years) ≥5 years after cancer diagnosis, and 208 sibling controls (112 males, 13.6 ± 2.4 years) participated in this cross‐sectional study, which included anthropometry, body composition, and metabolic studies. Blunted response (BR) was defined as peak GH level <7 µg/L after clonidine and arginine. Insulin sensitivity (Mlbm) was measured by euglycemic hyperinsulinemic clamp. Statistical analyses used linear and logistic regression accounting for sibling clustering, adjusted for age, sex, Tanner stage, and adiposity.ResultsThirty‐four (12%) CCS showed BR to GH stimulation. BR CCS were shorter and had a lower IGF‐1 than controls; only 6 of 34 received cranial radiation therapy. CCS with normal stimulated GH response were similar to controls for CV risk factors. Conversely, BR CCS had greater adiposity, higher lipids, and lower Mlbm than controls. Differences in lipids and Mlbm between BR CCS and controls remained significant after adjustment for BMI or visceral fat.ConclusionsBR to GH stimulation is prevalent in CCS youth and is associated with an unfavorable CV risk factor profile. Further studies are needed to establish the mechanisms of these associations. Pediatr Blood Cancer 2013; 60: 467–473. © 2012 Wiley Periodicals, Inc.