bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Value of Angio CT Multislice for Pre-operative Assessment and Prediction of Post PCI Successful Intervention in Acute Coronary Syndromes Associated by Left Main Disease
Authors: Blendea Ciprian , Kovács István , Bărcan Andreea , Nyulas Tiberiu , Chițu Monica 
Published: November 2015

Abstract

Introduction: The location of culprit lesions on the left main is associated with an increased procedural risk in acute coronary syndromes. Our study aims to evaluate the utility of CT angiography determined Syntax score (CCTA) in comparison with the classical angiographic Syntax score for predicting the procedural success in percutaneous coronary interventions (PCI) of left main lesions.

Methods: We included 23 patients presenting to the Cardiology Clinic with an acute coronary syndrome. All patients underwent coronary angiography ± angio CT multisclice for assessment of the target lesion, defined as a significant (>50%) left main disease. Patient population consisted in: group 1 – 13 patients (56.52%), in whom revascularization indication was based on lesion severity assessment by CCTA score correlated with the angio Syntax score (SS), and group 2 – 10 patients (43.48%), in whom revascularization indication was based only on angio SS. According to the SS, the study population was divided into subgroup A – low SS (<22), subgroup B – intermediate SS (23–32) and subgroup C –high SS (>32). All patients were followed for 1 year.

Results: Despite similar SS in both groups (35.38 in group 1 vs. 32.4 in group 2), the use of Angio CT multislice increased the rate of PCI indication – 76.92% PCI in group 1 versus 50% PCI in group 2. In patients with high SS, PCI rate was 66.66% in group 1 compared with 50% in group 2 (p<0.05). High calcium score >100 was recorded in 50% of patients in the low SS subgroup (<22), 50% in the medium SS subgroup (23–32) and 22.22% in the high SS (>33) subgroup. One-year follow-up showed an overall mortality of 8.69%, slightly higher in group 2 (10%), as compared to group 1 (mortality of 7.69%).

Conclusions: Additional evaluation by angio CT of culprit left main stenoses in acute coronary syndromes provides more information about the complexity of atherosclerotic plaques in this location, and could be extremely useful in establishing the indication for PCI in high risk stenoses, showing a predictive significance for post-procedural 1 year follow up mortality.
Effect of Artemisia annua L. essential oil on toxicity, enzyme activities, and energy reserves of cotton bollworm Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae)
Authors: Mojarab-Mahboubkar Malahat , Sendi Jalal Jalali , Aliakbar Alireza 
Published: November 2015

AbstractThe essential oil of Artemisia annua L., a weed collected from northern Iran, was studied for its toxicity and physiological aspects on 4th instar larva of the cotton bollworm Helicoverpa armigera Hübner in controlled conditions (26±1°C, 65±10% RH and 16 L : : 8 D h). The artificial diet was used as a medium for investigating the toxicity and the effect of LC10, LC30, LC50, and LC90on the feeding efficiency of 4th instar larva. The essential oil in doses of LC10, LC30, LC50, and LC90were estimated to be 2.01%, 3.86%, 6.07%, and 18.34%, respectively. The activity of α-amylase, protease, lipase, general esterases, and glutathione S-transferase and protein, triglyceride, glucose for treated larva were measured. The results showed that all of these parameters were decreased compared with the control. Hence, A. annua essential oil is suggested as a botanical for controlling this important pest of field crops.
Exploratory Study: Stress, Coping and Support among Parents of Children with Autism Spectrum Disorders
Authors: Nolcheva Meri , Trajkovski Vladimir 
Published: November 2015

Abstract: Each year more families are confronted with unique challenges related to raising a child with ASD. Parenting stress is a significant aspect of fulfilling the role as a parent, and having a child with ASD greatly influences the experienced stress. The literature review indicates that parenting stress is inversely proportional to family support and coping mechanisms.Appraising the stress level among parents of children with ASD, the coping mechanisms and the level of family support, in comparison with parents of children diagnosed with ID.: A group of parents of children with ASD (N=35) and a second group of children with ID (N=35) completed four question-nnaires: PSI-SF, Brief COPE, FSS and demographic questionnaire. The data was analyzed using t-test for comparison, Chi-square test for comparing frequency distributions and Pearson coefficient for correlation, with: Parenting stress did not differ between the two groups. The coping mechanisms used by the parents of children with ASD showed that increased usage of distraction (: There are no differences in the level of stress, coping mechanisms and the level of support comparing parents of children with ASD and ID.
Data-Driven Reversible Jump for QTL Mapping
Authors: Zuanetti Daiane Aparecida , Milan Luis Aparecido 
Published: November 2015

AbstractWe propose a birth–death–merge data-driven reversible jump (DDRJ) for multiple-QTL mapping where the phenotypic trait is modeled as a linear function of the additive and dominance effects of the unknown QTL genotypes. We compare the performance of the proposed methodology, usual reversible jump (RJ) and multiple-interval mapping (MIM), using simulated and real data sets. Compared with RJ, DDRJ shows a better performance to estimate the number of QTLs and their locations on the genome mainly when the QTLs effect is moderate, basically as a result of better mixing for transdimensional moves. The inclusion of a merge step of consecutive QTLs in DDRJ is efficient, under tested conditions, to avoid the split of true QTL’s effects between false QTLs and, consequently, selection of the wrong model. DDRJ is also more precise to estimate the QTLs location than MIM in which the number of QTLs need to be specified in advance. As DDRJ is more efficient to identify and characterize QTLs with smaller effect, this method also appears to be useful and brings contributions to identifying single-nucleotide polymorphisms (SNPs) that usually have a small effect on phenotype.
Dexmedetomidine: A Review of a Newer Sedative in Dentistry
Authors: Devasya A , Sarpangala M 
Published: November 2015

Dexmedetomidine is a central α-2 agonist, similar to Clonidine, but 8 times more specific for the central α-2 receptor which causes sedation with minimal depression of respiration, making it safe for sedation during procedures. It is widely used in the field of medicine for many procedures especially premedication, awake intubation, and sedation of patients in intensive care units and pediatric procedural sedation.
Objective: To do a systematic review of the pharmacology, pharmacodynamics, as well as the usage of newer sedative drug- Dexmedetomidine in dentistry. Study design: The search for articles was conducted in Pub Med, including the articles published in English until Oct 2014. Both animal and human studies were included using the key words, “Dexmedetomidine”, “Dexmedetomidine in sedation”, “Dexmedetomidine in Dentistry”, and “Dexmedetomidine in Pediatric dentistry”. The Articles obtained were checked for their quality methodology and inference of the studies and selected for review. Results: Initial search retrieved 2436 articles, out of which 44 articles were on the subject of Dexmedetomidine in dentistry. Five of which articles were on the usage of Dexmedetomidine in pediatric dentistry. These studies were included in systematic review. Conclusion: The study revealed that Dexmedetomidine being a new drug with its added advantages makes a better choice for sedation in dentistry. But with limited studies on Dexmedetomidine, the recommendation to use the drug exclusively is still under debate.
Comparative Mortality and Risk Factors for Death among US Supreme Court Justices (1789-2013)
Authors: Reynolds Robert J. , Kush Scott J. , Day Steven M. , Vachon Pierre 
Published: November 2015

Objectives
To compare the mortality experience of 112 justices of the US Supreme Court with that expected in the general population. To identify variables associated with mortality within this cohort.

Background
Supreme Court justices are a select occupational cohort. High socio-economic status, advanced education, lifetime appointment, and the healthy worker effect suggest lower mortality. Sedentary work, stress, and a tendency to work beyond typical retirement age may attenuate this.

Methods
Standardized mortality ratios compare the observed mortality rates of justices with those expected in age- and sex-matched contemporary general populations. Poisson regression analyzes variables associated with mortality within the cohort.

Results
From 1789 to 2013, 112 justices (108 male) contributed 2,355 person-years of exposure. Mean age (standard deviation) at appointment was 53.1 years (6.7); at retirement 69.7 years (9.9); at death (n = 100) 74.4 years (10.3); and at end of the study for those alive (n = 12) 72.1 years (11.8). Standardized mortality ratios (95% ci) were: overall 0.87 (0.70-1.05); prior to 1950 0.92 (0.61-1.33); and from 1950 to 2013 0.66 (0.42-0.99). Variables in the final Poisson model and their associated mortality rate ratios (95% ci) were: age 1.06 (1.03-1.09); calendar year 0.99 (0.99-1.00); active status 0.41 (0.25-0.68); career length 1.04 (1.01-1.07); and chief justice 1.08 (0.59-1.84).

Conclusions
Supreme Court mortality was lower than that of the general population in the period from 1950 to the present, but was on par prior to 1950. Increasing age and career length were associated with greater mortality, while active status and later calendar year with lower. These results may add to a body of knowledge that may help to develop or refine models of mortality risk in increasingly aged working populations.
Producción de metano a partir de desechos orgánicos generados en el Tecnológico de Costa Rica
Authors: Guillén Watson Rossy , Rivas Solano Olga 
Published: November 2015

<p>En la planta de tratamiento de aguas residuales del Tecnológico de Costa Rica (TEC) se instalaron cuatro biodigestores a escala. Los biodigestores se numeraron como 1, 2, 4 y 5. Todos los biodigestores se alimentaron manualmente dos veces por semana durante dos meses. A los biodigestores 1 y 5 se les agregó una mezcla de agua residual y lirios acuáticos (Eichhornia crassipes) previamente triturados y desecados. Los biodigestores 2 y 4 se alimentaron con agua residual solamente. La producción de metano se midió utilizando un analizador de gases portátil y los parámetros asociados a la degradación de materia orgánica se caracterizaron utilizando los protocolos descritos por Clesceri y colaboradores (2005).</p> <p>Al final del periodo de evaluación, los biodigestores 1 y 5 presentaron una concentración de metano cercana al 50%, mientras que en los biodigestores 2 y 4 fue de aproximadamente 30%. Estos resultados indican que la adición de lirios como fuente de carbono mejoró la calidad del biogás. Sin embargo, para lograr una mejor degradación de la materia orgánica, se recomienda aumentar el tiempo de retención. Además se recomienda estudiar la productividad metanogénica de otras combinaciones de desechos que también se producen en la institución, como por ejemplo los residuos de la soda comedor.</p>
Nivel de madurez para la gestión de la innovación en el sector eléctrico: caso de investigación de campo aplicado en Costa Rica
Authors: Gutiérrez-Sandí William , Gracia-Villar Santos , Dzul-López Luis Alonso , Fernández Díez Federico 
Published: November 2015

<p>Los nuevos modelos económicos provocan que las organizaciones deban responder de manera rápida a los diferentes cambios que generan los actores y el mismo entorno en los mercados. La gestión de las iniciativas de innovación por medio de proyectos se convierte en una útil herramienta de gestión empresarial. No obstante, cabe la pregunta sobre cuál será el grado de madurez con el que las organizaciones realizan dichas gestiones.</p> <p>Para ello, el Modelo de Madurez La Pirámide Invertida (MMPI) constituye una herramienta con la cual es posible valorar la gestión estructurada y sistemática del proceso innovador en la organización. Dicha herramienta fue aplicada al sector de distribución de Energía Eléctrica en Costa Rica, Latinoamérica. Mediante la aplicación de una investigación exploratoria, se documentó el estado actual de algunas organizaciones del sector que sirven como referencia para realizar un análisis del mismo. El método científico fue la guía metodológica para el planteamiento y desarrollo de la presente investigación.</p> <p>Los resultados obtenidos reflejan una realidad latente en muchas organizaciones de este y otros sectores productivos. A partir de este primer esfuerzo será posible conocer cuál es esa realidad y las medidas que deben ser tomadas para poder contar con sectores productivas más eficientes y organizaciones que generen mayor valor.</p>
Tratamiento de desechos del cianuro por biorremediación
Authors: Deloya Martínez Alma 
Published: November 2015

Se presentan los resultados de una investigación en la que se desarrolló un consorcio autóctono de microorganismos degradadores del cianuro para aplicarlo en el tratamiento biológico de los desechos peligrosos del cianuro. Los microorganismos autóctonos obtenidos se liofilizaron en diferentes medios protectores, como la gelatina y caldo lactosado a diferentes temperaturas (-35,-45,-55 y -65). Para el tratamiento preliminar de los desechos del cianuro se aplicó un método de pretratamiento en lechada: para la lixiviación preliminar del desecho, con periodos de 3-5 días y un tratamiento posterior, por lagunas aireadas, aplicando el consorcio de microorganismos liofilizados.Se obtuvieron ocho diferentes liofilizados bajo diferentes condiciones de temperatura y con dos medios protectores de liofilización que presentaron excelentes recuperaciones a los seis meses de la liofilización.El consorcio de microorganismos liofilizados presentó, viabilidad del 70 al 80%, con porcentajes de remoción del cianuro mayores al 95% y puede conservarse activo por tiempos prolongados (por años).Los microorganismos liofilizados pueden aplicarse en la biodegradación de los desechos del cianuro procedentes de las minas de oro o cualquier otro desecho de cianuro como los baños de electrodeposición de metales, además de aquellos procedentes de la industria manufacturera de joyas.
Modification of optical properties of seawater exposed to oil contaminants based on excitation-emission spectra
Authors: Baszanowska E. , Otremba Z. 
Published: November 2015

The optical behaviour of seawater exposed to a residual amount of oil pollution is presented and a comparison of the fluorescence spectra of oil dissolved in both n-hexane and seawater is discussed based on excitation-emission spectra.
Crude oil extracted from the southern part of the Baltic Sea was used to characterise petroleum properties after contact with seawater. The wavelength-independent fluorescence maximum for natural seawater and seawater artificially polluted with oil were determined. Moreover, the specific excitation-emission peaks for natural seawater and polluted water were analysed to identify the natural organic matter composition. It was found that fluorescence spectra identification is a promising method to detect even an extremely low concentration of petroleum residues directly in the seawater. In addition, alien substances disturbing the fluorescence signatures of natural organic substances in a marine environment is also discussed.
Tangeretin prevents prostate cancer cell proliferation and induces apoptosis via activation of Notch signalling and regulating the androgen receptor (AR) pathway and the phosphoinositide 3-kinase (PI3k)/Akt/mTOR pathways
Authors: Guo Jin-Jin , Li Ying-Jie , Xin Lu-Lu 
Published: November 2015

<p class="Abstract">Despite advances in conventional therapies, treatment of prostate cancer is still a challenge. The study aims to assess the possible anti-cancer effects of tangeretin, a dietary flavonoid on human prostate cancer cells (DU145, PC3, LNCaP). Tangeretin (25, 50 and 100 µM) significantly inhibited cancer cell viability and induced DNA fragmentation and apoptosis by increasing caspase-3 and pro-apoptotic proteins (Bad and Bax) with reduced anti-apoptotic proteins (Bcl-2 and Bcl-xL) expressions. Significant inhibition of androgen receptor (AR) and prostate specific antigen (PSA) were seen. Dose-dependent inhibition in Notch signal was observed in expression of Notch 1 and Jagged 1 along with PI3/Akt/mTOR signalling pathway. The results suggest that tangeretin inhibited prostate cancer cell proliferation and induced apoptosis via inhibiting critical pathways in cancer development - AR signalling and PI3/Akt/mTOR - Notch signalling pathways.</p><p> </p>
Magnetic resonance imaging assisted management in five cases of suspected quittor
Authors: Taylor Sarah , Labens Raphael , Cillán-García Eugenio , Meehan Lucinda 
Published: November 2015

SummaryObjectives: Assessment of the usefulness of magnetic resonance imaging (MRI) in treatment planning in suspected cases of quittor in the horse.Methods: Five horses with chronic discharging tracts at the level of the foot underwent MRI for treatment planning.Results: The MRI examination revealed variable involvement of soft tissue and osseous structures of the foot in addition to abnormalities of the ungular cartilages in all cases. In two cases, follow-up MRI examination was performed. Four of five horses had a successful outcome, with three of these undergoing only one surgical procedure and one being managed medically.Clinical significance: We believe that the use of preoperative MRI facilitated accurate determination of the structures involved in cases of quittor, guiding the management, surgical approach and postoperative therapy.
Divergent growth strategies between red algae and kelps influence biomechanical properties
Authors: Krumhansl Kira A. , Demes Kyle W. , Carrington Emily , Harley Christopher D. G. 
Published: November 2015

PREMISE OF THE STUDY:Morphology and material properties are the main components of the mechanical design of organisms, with species groups developing different optimization strategies in the context of their physical environment. For intertidal and subtidal seaweeds, possessing highly flexible and extensible tissues allows individuals to bend and reconfigure in flow, thereby reducing drag. Previous research has shown that aging may compromise these qualities. Tissue age increases with distance from the blade's meristem, which differs in its position on kelps and red algae. Here, we assess whether longitudinal patterns of blade material properties differ between these two algal groups according to tissue age.METHODS:We performed tensile tests on tissues samples excised from various positions along the extent of blades in nine kelp species (basal growth) and 15 species of red algae (apical growth).KEY RESULTS:We found that older tissues were less flexible and extensible than younger tissues in all species tested. As predicted, tissue near the basal meristem in kelp was more flexible and extensible than older tissue at the blade's distal end. The opposite pattern was observed for red algae, with the most flexible and extensible tissues found near the apical meristem at the distal ends of blades.CONCLUSIONS:We propose that divergent patterns in the distribution of material properties along blades may have different consequences for the performance of kelps and red algae. The positioning of younger tissues at the blade base for kelps may enable these species to attain larger body sizes in wave‐swept habitats.
Designing Simulation Scenarios to Support Performance Assessment Validity
Authors: O'Brien Janet E. , Hagler Debra , Thompson Marilyn S. 
Published: November 2015

How to Obtain Contact Hours by Reading This IssueInstructions: 1.2contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz.A contact hour certificate will be awarded after you register, pay the registration fee, and complete the evaluation form online athttp://goo.gl/gMfXaf.In order to obtain contact hours you must:1.Read the article, “Designing Simulation Scenarios to Support Performance Assessment Validity,” found on pages 492–498, carefully noting any tables and other illustrative materials that are included to enhance your knowledge and understanding of the content. Be sure to keep track of the amount of time (number of minutes) you spend reading the article and completing the quiz.2.Read and answer each question on the quiz. After completing all of the questions, compare your answers to those provided within this issue. If you have incorrect answers, return to the article for further study.3.Go to the Villanova website to register for contact hour credit. You will be asked to provide your name, contact information, and a VISA, MasterCard, or Discover card number for payment of the $20.00 fee. Once you complete the online evaluation, a certificate will be automatically generated.This activity is valid for continuing education credit untilOctober 31, 2018.Contact HoursThis activity is co-provided by Villanova University College of Nursing and SLACK Incorporated.Villanova University College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.ObjectivesDescribe a formal validation process for simulation scenarios.Explain how relationships among competencies, measurement tools, and scenario content support validity of simulation-based performance assessment data.Disclosure StatementNeither the planners nor the authors have any conflicts of interest to disclose.This article advances and demonstrates a validation process to guide the development of health care simulation scenarios for assessing performance competency. The development and evaluation of each scenario used in a simulation-based competency assessment must be based on multiple sources of evidence that support the validity of the assessment for its intended use. Procedures are proposed to optimize the validity of simulation-based assessments by linking the scenario directly to the instrument and using a systematic approach for gathering and processing input from experts in the field. This validation process is then applied to the development of an original scenario for use in an assessment of nursing competency that targets objectives through patient simulation scenarios scored by multiple raters.J Contin Educ Nurs.2015;46(11):492–498.