bluuebunny/crossref_metadata_2025_split huggingface dataset:
TLR7- and TLR9-Responsive Human B Cells Share Phenotypic and Genetic Characteristics
Authors: Simchoni Noa , Cunningham-Rundles Charlotte 
Published: March 2015

Abstract
B cells activated by nucleic acid–sensing TLR7 and TLR9 proliferate and secrete immune globulins. Memory B cells are presumably more responsive due to higher TLR expression levels, but selectivity and differential outcomes remain largely unknown. In this study, peripheral blood human B cells were stimulated by TLR7 or TLR9 ligands, with or without IFN-α, and compared with activators CD40L plus IL-21, to identify differentially responsive cell populations, defined phenotypically and by BCR characteristics. Whereas all activators induced differentiation and Ab secretion, TLR stimulation expanded IgM+ memory and plasma cell lineage committed populations, and favored secretion of IgM, unlike CD40L/IL-21, which drove IgM and IgG more evenly. Patterns of proliferation similarly differed, with CD40L/IL-21 inducing proliferation of most memory and naive B cells, in contrast with TLRs that induced robust proliferation in a subset of these cells. On deep sequencing of the IgH locus, TLR-responsive B cells shared patterns of IgHV and IgHJ usage, clustering apart from CD40L/IL-21 and control conditions. TLR activators, but not CD40L/IL-21, similarly promoted increased sharing of CDR3 sequences. TLR-responsive B cells were characterized by more somatic hypermutation, shorter CDR3 segments, and less negative charges. TLR activation also induced long positively charged CDR3 segments, suggestive of autoreactive Abs. Testing this, we found culture supernatants from TLR-stimulated B cells to bind HEp-2 cells, whereas those from CD40L/IL-21–stimulated cells did not. Human B cells possess selective sensitivity to TLR stimulation, with distinctive phenotypic and genetic signatures.
Psychosocial, psychiatric, and clinical implications of diabetic foot ulceration: A prospective analysis
Authors: Neeru Bala , Gagandeep Kaur , Pal Attri , Bajwa Sukhminder , Harbandna Sawney , Rajesh Kumar 
Published: March 2015

Abstract
Background: Foot ulceration is very common complication of diabetes. Prevalence of psychiatric disorders is considered to be more in patients suffering from diabetic foot ulcers. Aim: The present study was carried out to observe and evaluate the various psychiatric disorders experienced by patients with diabetic foot ulceration, management of these disorders, and the metabolic abnormalities associated with the use of antipsychotic drugs. Materials and Methods: In this observational study, 293 patients in the age group of 25-70 years of either sex, who visited this hospital for the management of diabetic foot ulcers, were included after taking informed consent. They were prospectively followed for a period of 24 months. A phenomenological approach using semi-structured, conversational interviews was used. They were interviewed for the type of diabetes, duration of diabetes and duration of foot ulcer and other complications, type of treatment for diabetes and diabetic foot, psychosocial effects of foot ulceration on their daily The Hamilton rating scale for depression, questionnaire was used for assessing depression while the Hamilton anxiety rating scale questionnaire was used to rate the severity of anxiety. The data collected and analyzed for the type of psychiatric disorder, treatment options, type of drugs given and any side effects or complications occur as a result of these drugs. Descriptive statistical methods were used to analyze the data. Conclusion: Diabetic foot ulcer is associated with an increased incidence of various psychiatric disorders, depression being the most common among these. Drugs used to treat depression and associated with metabolic disturbances. Hyperglycemia associated with the use of antidepressants and antipsychotics further worsens the foot ulceration. Coordination between different specialties is important to manage the clinical, biological, and psychosocial aspects of this critical illness.
Where are they? The inclusion of African-American men in empirical studies of type 2 diabetes self-care management
Authors: Sherman Ledric , McKyer E. 
Published: March 2015

Abstract
Background: African-American Men experience higher rates of serious complications of diabetes, due in part to poor disease management. Yet it is unclear to what extent research been devoted to type 2 diabetes management in this population. Purpose: A need exists to clarify the extant literature on self-care management (SCM) practices of African-American Men with type 2 diabetes. Materials and Methods: A systematic literature and methodological quality scoring (MQS) using the Garrard matrix method was performed. Low scores (0-1) indicate low representation of African-American men; highest score (3) indicate high inclusion of African-American men in the samples. The search targeted articles focused on type 2 diabetes self-care management, and which included samples of African-American Men. Each publication was reviewed and assigned a MQS by the researchers, who reached 100% concordance with the MQS. Results: Initial screening yielded 122 articles, but only 41 met full study inclusion criteria. These studies represent a combined sample size of 9,171 participants of which less than one-third (3,007; 32.8%) were clearly identifiable as African-American men. Only 7 studies had samples consisting 100% of African-American Men. Mixed methods approaches were used least (n = 9 studies), followed by quantitative approaches (n = 15 studies). Qualitative approaches was most commonly used (n = 17 studies). Most (n = 24) studies scored low (0 to 1 score), indicating low-level of inclusion of African-American Men in their sample. Discussion: In spite of the growing body of literature on managing type 2 diabetes, there is a paucity of information focused on a high-need and high-risk group - African-American Men. The exclusion of this population can result in adverse health consequences, given the high comorbidities associated with uncontrolled diabetes. Conclusion: Including more African-American Men in self-care management studies can help determine the factors affecting research participation among this group as well as to further understand the complexity that these men face regarding managing their diabetes.
Anatomical description of double left suprarenal vein and its implications on renal transplantation surgeries
Authors: Assis T. , Fernandes L. , Araújo Filho J. 
Published: March 2015

Abstract
Introduction: Left suprarenal vein (LSRV) is a tributary of the left renal vein in more than 95% of the population. In a research carried out by Mas, Arango, Guzmán et al. (1987), the double suprarenal vein appeared on 2.7% of the 110 nephrectomies done. The suprarenal vein (SRV) was unique on the 34 bodies analyzed by Duques, Rodrigues, Silva Neto et al. (2002). Therefore, the anatomical variations of the LSRV are rare, but its study is a subject of clinic and surgical importance for renal transplants. The objective of this study was to describe the dissection of the double LSRV. Material and Methods: A caliper rule was used to measure the length of the studied veins. The dissection of the left kidney and adrenal was done according to standard technique. Results: The different origins and trajectories of the double LSRV (normal and variant), tributaries and left renal vein were verified. The normal LSRV measured 3 cm up to the renal vein whereas the variant SRV, with 7.5 cm and thinner, went out of the lateral suprarenal border, went down adjacent to the kidney face to end in the left renal vein around 1.8 cm distal to the first. Conclusions: The variant SRV showed double the normal length, lower diameter and difficult visualization in situ because of its trajectory between the superior pole of the kidney and the suprarenal anterior face. This trajectory evokes extra care during surgical procedures of renal transplantation, mostly to avoid hypotension and hypovolemia after SRV ligation.
Morphologic aspects of the genital tract from Nellore cows undergoing gynecological screening to insertion in the fixed-time artificial insemination (TAI) program
Authors: Mello R. , Mello M. , Abidu-Figueiredo M. , Scherer P. , Palhano H. 
Published: March 2015

Abstract
Introduction: This study aimed to evaluate the morphology of the genital tract from 98 Nellore cows by rectal palpation and combine them with the functional aspects for inclusion in a fixed-time artificial insemination (TAI) program. Methods: Were evaluated the ovaries, cervix and vulva, as well as the body condition score (BCS scale 1-5). Results: In relation to the ovaries, there were palpable structures found in 51 (17 CL and 34 FL) in the rights ovarian and 37 palpable structures (06 CL and 31 FL) in the left ovary. Asymmetry was found in 17.3% and uterine cervicitis in 20.4% of examined females. Changes were noted in vulva in 51.0% (40 to 10 papules and hyperemia) and the average of BCS was 3.15. On the basis of morphological aspects founded, 29 females with an average of BCS 2.7 and 01 with metritis were excluded and 07 (BCS-3, 5) inseminated immediately after the exam, with 61 included in the TAI program. These data support the conclusion that of all ovulations occurred, characterized by the presence of CL, most occurred in the right ovary (73.9%). The prevalence rate (51%) of vulvar aspects found, indicate a need for research of reproductive diseases in their flock. Conclusion: The BCS may impacts on the cyclicity and in the pregnancy rate of females included in the program.
China's Cultural Revolution and Japan's Intelligentsia:
Authors: Ge Shi 
Published: March 2015

Abstract
This article is intended to analyze the impacts of China's Cultural Revolution on Japan, from the social, political, literary and cultural perspectives in an attempt to demonstrate the characteristic of the Japanese intelligentsia's response, as well as to prove that the Cultural Revolution is a global revolutionary storm. This article also focuses on Kazumi Takahashi, who was a litterateur as well as one of the witnesses of the Cultural Revolution. He regarded Cultural Revolution as the “moral movement” from the approach of “as a human being,” which was quite different from the other intelligentsia.
Simone de Beauvoir Abroad:
Authors: Van Houten Christina 
Published: March 2015

Abstract
A critical analysis of Simone de Beauvoir's The Long March, this article argues that de Beauvoir's experience of Maoism, social realist literature, and socialist feminism influenced her political theory and practice during the cold war. What differentiated de Beauvoir among French Maoists in the 1960s and 1970s was her attention to Chinese socialist feminists and the ways in which their activism advocated for gender and class equality, putting pressure on cultural articulations of women's productive and nonproductive labor. In turn, I argue that de Beauvoir's focus on Chinese socialist feminism informed her relationship with the women's liberation movement, both in the United States and in France.
Sustaining an International Partnership: An Evolving Collaboration
Authors: Pierson Melinda R. , Myck-Wayne Janice , Stang Kristin K. , Basinska Anna 
Published: March 2015

Abstract
Universities across the United States have an increasing interest in international education. Increasing global awareness through educational collaborations will promote greater cross-cultural understanding and build effective relationships with diverse communities. This paper documents one university's effort to build an effective international partnership to support the education of people with disabilities in Poland and details common goals and strategies for the overall sustainability of an international partnership between two universities.
Double‐blind, placebo‐controlled study of HGF gene therapy in diabetic neuropathy
Authors: Kessler John A. , Smith A. Gordon , Cha Bong‐Soo , Choi Sung Hee , Wymer James , Shaibani Aziz , Ajroud‐Driss Senda , Vinik Aaron ,   VM202 DPN‐II Study Group
Published: March 2015

AbstractObjectiveTo evaluate the safety and efficacy of a plasmid (VM202) containing two human hepatocyte growth factor isoforms given by intramuscular injections in patients with painful diabetic neuropathy.MethodsIn a double‐blind, placebo‐controlled study, patients were randomized to receive injections of 8 or 16 mg VM202 per leg or placebo. Divided doses were administered on Day 0 and Day 14. The prospective primary outcome was change in the mean pain score measured by a 7 day pain diary. Secondary outcomes included a responder analysis, quality of life and pain measures, and intraepidermal nerve fiber density.ResultsThere were no significant adverse events attributable to VM202. Eighty‐four patients completed the study. Patients receiving 8 mg VM202 per leg improved the most in all efficacy measures including a significant (P = 0.03) reduction at 3 months in the mean pain score and continued but not statistically significant reductions in pain at 6 and 9 months. Of these patients, 48.4% experienced a ≥50% reduction in pain compared to 17.6% of placebo patients. There were also significant improvements in the brief pain inventory for patients with diabetic peripheral neuropathy and the questionnaire portion of the Michigan Neuropathy Screening Instrument. Patients not on pregabalin or gabapentin had the largest reductions in pain.InterpretationVM202 was safe, well tolerated and effective indicating the feasibility of a nonviral gene therapy approach to painful diabetic neuropathy. Two days of treatment were sufficient to provide symptomatic relief with improvement in quality of life for 3 months. VM202 may be particularly beneficial for patients not taking gabapentin or pregabalin.
Ileosigmoidal knotting, an unusual form of acute intestinal obstruction
Authors: Cakir Murat , Tekin Ahmet , Kucukkartallar Tevfik , Kartal Adil 
Published: March 2015

AimIleosigmoidal knotting is an unusual form of acute intestinal obstruction characterized by closed‐loop obstruction of both ileum and sigmoid colon. We present 36 cases of ileosigmoidal knotting.MethodsA retrospective analysis was designed to examine preoperative, operative, and postoperative findings of the 36 patients with ileosigmoidal knotting who were surgically treated in Necmettin Erbakan University's Meram Medical Faculty (Konya, Turkey) throughout a 26‐year period.ResultsThe mean age was 55 (range, 47–61) years. The most common symptoms were abdominal pain, distention, obstipation, and vomiting, and the most common signs were abdominal tenderness and distention. The preoperative diagnosis was acute obstructed bowel in all patients. After resuscitation, all patients underwent emergency laparotomy. The most common type of ileosigmoidal knotting was type IA, in which the active ileum encircled the passive sigmoid in a clockwise manner. There was gangrene in both ileum and sigmoid colon in all patients. All ischemic bowels including ileum and sigmoid colon were resected and the continuity was carried out using primary anastomosis or Hartmann's procedure.ConclusionsIleosigmoidal knotting is a rare disease but its preoperative diagnosis is difficult. In cases of knotting there is no form of conservative treatment. Resective surgery is absolutely necessary.
Genetically expanded cell‐free protein synthesis using endogenous pyrrolysyl orthogonal translation system
Authors: Chemla Yonatan , Ozer Eden , Schlesinger Orr , Noireaux Vincent , Alfonta Lital 
Published: March 2015

ABSTRACTCell‐free protein synthesis offers a facile and rapid method for synthesizing, monitoring, analyzing, and purifying proteins from a DNA template. At the same time, genetic code expansion methods are gaining attention due to their ability to site‐specifically incorporate unnatural amino acids (UAAs) into proteins via ribosomal translation. These systems are based on the exogenous addition of an orthogonal translation system (OTS), comprising an orthogonal tRNA, and orthogonal aminoacyl tRNA synthetase (aaRS), to the cell‐free reaction mixture. However, these components are unstable and their preparation is labor‐intensive, hence introducing a major challenge to the system. Here, we report on an approach that significantly reduces the complexity, effort and time needed to express UAA‐containing proteins while increasing stability and realizing maximal suppression efficiency. We demonstrate an endogenously introduced orthogonal pair that enables the use of the valuable yet insoluble pyrrolysyl‐tRNA synthetase in a cell‐free system, thereby expanding the genetic repertoire that can be utilized in vitro and enabling new possibilities for bioengineering. With the high stability and efficiency of our system, we offer an improved and accessible platform for UAA incorporation into proteins. Biotechnol. Bioeng. 2015;112: 1663–1672. © 2015 Wiley Periodicals, Inc.
Antibody Induction Directed against the Tumor‐Associated MUC4 Glycoprotein
Authors: Cai Hui , Palitzsch Björn , Hartmann Sebastian , Stergiou Natascha , Kunz Horst , Schmitt Edgar , Westerlind Ulrika 
Published: March 2015

AbstractMucin glycoproteins are important diagnostic and therapeutic targets for cancer treatment. Although several strategies have been developed to explore anti‐tumor vaccines based on MUC1 glycopeptides, only few studies have focused on vaccines directed against the tumor‐associated MUC4 glycoprotein. MUC4 is an important tumor marker overexpressed in lung cancer and uniquely expressed in pancreatic ductual adenocarcinoma. The aberrant glycosylation of MUC4 in tumor cells results in an exposure of its peptide backbone and the formation of tumor‐associated glycopeptide antigens. Due to the low immunogenicity of these endogenous structures, their conjugation with immune stimulating peptide or protein carriers are required. In this study, MUC4 tandem‐repeat glycopeptides were conjugated to the tetanus toxoid and used for vaccination of mice. Immunological evaluations showed that our MUC4‐based vaccines induced very strong antigen‐specific immune responses. In addition, antibody binding epitope analysis on glycopeptide microarrays, were demonstrating a clear glycosylation site dependence of the induced antibodies.
Characterization of the Nocardiopsin Biosynthetic Gene Cluster Reveals Similarities to and Differences from the Rapamycin and FK‐506 Pathways
Authors: Bis Dana M. , Ban Yang H. , James Elle D. , Alqahtani Norah , Viswanathan Rajesh , Lane Amy L. 
Published: March 2015

AbstractMacrolide‐pipecolate natural products, such as rapamycin (1) and FK‐506 (2), are renowned modulators of FK506‐binding proteins (FKBPs). The nocardiopsins, from Nocardiopsis sp. CMB‐M0232, are the newest members of this structural class. Here, the biosynthetic pathway for nocardiopsins A–D (4–7) is revealed by cloning, sequencing, and bioinformatic analyses of the nsn gene cluster. In vitro evaluation of recombinant NsnL revealed that this lysine cyclodeaminase catalyzes the conversion of L‐lysine into the L‐pipecolic acid incorporated into 4 and 5. Bioinformatic analyses supported the conjecture that a linear nocardiopsin precursor is equipped with the hydroxy group required for macrolide closure in a previously unobserved manner by employing a P450 epoxidase (NsnF) and limonene epoxide hydrolase homologue (NsnG). The nsn cluster also encodes candidates for tetrahydrofuran group biosynthesis. The nocardiopsin pathway provides opportunities for engineering of FKBP‐binding metabolites and for probing new enzymology in nature's polyketide tailoring arsenal.
Modeling of a Slurry Bubble Column Reactor for the Production of Biofuels via the Fischer‐Tropsch Synthesis
Authors: Vik Camilla Berge , Solsvik Jannike , Hillestad Magne , Jakobsen Hugo A. 
Published: March 2015

AbstractThe Fischer‐Tropsch synthesis carried out in a slurry bubble column is modeled with a focus on the production of liquid fuels from biomass. Mass, momentum and energy balances are formulated for the gas, liquid and solid phases and solved by the orthogonal collocation method. A multifluid population balance model is utilized. The interfacial area between the gas and liquid phases can be calculated directly from a mass density function of the bubbles. Five different compositions of feed synthesis gas representing biomass (with and without water‐gas shift reaction), coal (with and without autothermal reforming), and natural gas (after autothermal reforming) are simulated to highlight the effect of the synthesis gas composition.
Mechanochromic Luminescence of Copper Iodide Clusters
Authors: Benito Quentin , Maurin Isabelle , Cheisson Thibaut , Nocton Gregory , Fargues Alexandre , Garcia Alain , Martineau Charlotte , Gacoin Thierry , Boilot Jean‐Pierre , Perruchas Sandrine 
Published: March 2015

AbstractLuminescent mechanochromic materials are particularly appealing for the development of stimuli‐responsive materials. Establishing the mechanism responsible for the mechanochromism is always an issue owing to the difficulty in characterizing the ground phase. Herein, the study of real crystalline polymorphs of a mechanochromic and thermochromic luminescent copper iodide cluster permits us to clearly establish the mechanism involved. The local disruption of the crystal packing induces changes in the cluster geometry and in particular the modification of the cuprophilic interactions, which consequently modify the emissive states. This study constitutes a step further toward the understanding of the mechanism involved in the mechanochromic luminescent properties of multimetallic coordination complexes.
ChemInform Abstract: The Germanides ScTGe (T: Co, Ni, Cu, Ru, Rh, Pd, Ag, Ir, Pt, Au) — Structure and 45Sc Solid State NMR Spectroscopy.
Authors: Heying Birgit , Haverkamp Sandra , Rodewald Ute Ch , Eckert Hellmut , Peter Sebastian C. , Poettgen Rainer 
Published: March 2015

AbstractScMGe (M: Co, Ni, Cu, Ru, Rh, Pd, Ag, Ir, Pt, Au) are obtained in pure form by arc‐melting of the elements.
ChemInform Abstract: Synthesis and Photoluminescence Properties of Novel Red Emitting Phosphor Sr2LiSiO4F:Eu3+.
Authors: Xie Mubiao , Zeng Lihua , Zhou Xiaoping , Xie Feifei 
Published: March 2015

AbstractNovel red phosphors Sr2LiSiO4F:xEu3+ (0.01 ≤ x ≤ 0.15) are prepared by solid‐state reaction of stoichiometric amounts of Li2CO3, SrCO3, SiO2, NH4F, and Eu2O3 (900 °C, 6 h).
ChemInform Abstract: Yb14MgSb11 and Ca14MgSb11 — New Mg‐Containing Zintl Compounds and Their Structures, Bonding, and Thermoelectric Properties.
Authors: Hu Yufei , Wang Jian , Kawamura Airi , Kovnir Kirill , Kauzlarich Susan M. 
Published: March 2015

AbstractThe Zintl phases Yb14MgSb11 (I) and Ca14MgSb11 (II) are prepared by annealing mixtures of the elements in the molar ratio Yb(Ca):Mg:Sb of 14:2:11 (Nb tube in evacuated silica tubes, 1275 K for (I) and 1225 K for (II)).
ChemInform Abstract: The Synthesis, Structure, and Electrical Characterization of (SnSe)1.2TiSe2.
Authors: Merrill Devin R. , Moore Daniel B. , Ditto Jeffrey , Sutherland Duncan R. , Falmbigl Matthias , Winkler Markus , Pernau Hans‐Fridtjof , Johnson David C. 
Published: March 2015

AbstractThin films of the new title intergrowth compound consisting of a bilayer of SnSe and TiSe2 trilayer are prepared by self‐assembly from a precursor containing modulated layers of Sn‐Se and Ti‐Se, which is synthesized by deposition of elemental layers (annealing at 350 °C).
ChemInform Abstract: Synthesis, Structure and Total Conductivity of A‐Site Doped LaTiO3‐δ Perovskites.
Authors: Bradha M. , Hussain S. , Chakravarty Sujay , Amarendra G. , Ashok Anuradha 
Published: March 2015

AbstractLaTiO3‐δ and La0.8A0.2TiO3‐δ (A: Ba, Sr, Ca) are prepared by sol‐gel processing of La(NO3)3, alkali acetates, and (Pr‐O)4Ti using citric acid and PEG (60 °C, 8 h).
ChemInform Abstract: S = 2 Spin Ladders in the Sulfide Oxide BaFe2S2O.
Authors: Valldor Martin , Adler Peter , Prots Yurii , Burkhardt Ulrich , Tjeng Liu Hao 
Published: March 2015

AbstractThe title compound is prepared by solid state reaction of BaO, Fe, and S (quartz tube, 800 °C, 100 h) and characterized by single crystal XRD, magnetic measurements, and Moessbauer spectroscopy.