bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hierarchical Bifunctional NiO Electrocatalyst: Highly Porous Structure Boosting the Water Splitting Activity
Authors: Sarkar Sunny , Ali Sk Afsar , Sarkar Soumita , Raihan Abu , Banerjee Soumalya , Patra Astam K. 
Published: August 2024

AbstractThe development of an efficient, low‐cost and earth‐abundant electrocatalyst for water splitting is crucial for the production of sustainable hydrogen energy. However their practical applications are largely restricted by their limited synthesis methods, large overpotential and low surface area. Hierarchical materials with a highly porous three‐dimensional nanostructure have garnered significant attention due to their exceptional electrocatalytic properties. These hierarchical porous frameworks enable the fast electron transfer, rapid mass transport, and high density of unsaturated metal sites and maximize product selectivity. Here the process involved obtaining monodispersed microrod‐shaped Ni(OH)2 through a hydrothermal reaction, followed by a heat treatment to convert it into hierarchical microrod‐shaped NiO materials. N2 sorption analysis revealed that the BET surface area increased from 9 to 89 m2/g as a result of the heat treatment. The hierarchical microrod‐shaped NiO materials demonstrated outstanding bifunctional electrocatalytic water splitting capabilities, excelling in both HER and OER in basic solution. Overpotential of 347 mV is achieved at 10 mA/cm2 for OER activity, with a Tafel slope of 77 mV/dec. Similarly, overpotential of 488 mV is achieved at 10 mA/cm2 for HER activity, with a Tafel slope of 62 mV/dec.
Optimierung des Trittschallschutzes von Holzbalkendecken in Gründerzeithäusern – Teil 1: Problemstellung und Sanierungsmöglichkeiten
Authors: Neusser Maximilian , Wegerer Paul 
Published: August 2024

AbstractDie Gassner & Partner Baumanagement GmbH führte in Kooperation mit der TU Wien eine umfangreiche Untersuchung zur Optimierung des Trittschallschutzes bei der Sanierung von Gründerzeithäusern durch. Auch wenn Sanierungen bislang keinen bestimmten Trittschallanforderungen unterliegen, werden von Bewohnerinnen und Bewohnern oftmals hausinterne Geräusche als störend beschrieben. Im Zuge der Forschungsarbeit wurden verschiedene Parameter wie Estrichdicke, Trittschalldämmung, Schüttung und abgehängte Unterdecke variiert, um die Auswirkungen auf den Trittschallschutz zu analysieren. Das Ziel war, die Deckenaufbauten anhand der Klassifizierungsnorm ÖNORM B 8115‐5 zu beurteilen und auf Basis der Neubauanforderungen zu sanieren. Bereits die Bestandsanalyse an drei unterschiedlichen Objekten zeigte, dass bestehende Holztramdecken in Wiener Gründerzeithäusern einen durchaus passablen Trittschallschutz aufweisen. Die Variantenstudie belegt, dass die Ausführung der abgehängten Decke die größten Auswirkungen auf das Trittschallverbesserungsmaß hat. Bei der Beurteilung der Aufbauten ist der SpektrumanpassungswertCI,50‐2500für die Erreichung einer höheren Klassifizierung maßgeblich. Im Zuge der messtechnischen Begleitung mehrerer Sanierungsprojekte konnte nachgewiesen werden, dass die Sanierungsmaßnahmen objektübergreifend qualitativ reproduzierbar sind und die Neubauanforderungen auch bei Tramdeckensanierungen erreicht werden können.
P‐glycoprotein‐mediated herb–drug interaction evaluation between Tenacissoside G and paclitaxel
Authors: Hu Jiudong , Hu Yujie , Xu Lingyan , Chen Junjun , Shi Meizhi , Wu Wenhui , Yang Jiao , Han Yonglong 
Published: August 2024

AbstractP‐glycoprotein (P‐gp)‐mediated herb–drug interactions (HDIs) may impact drug efficacy and safety. Tenacissoside G (Tsd‐G), a major active component of Marsdenia tenacissima, exhibits anticancer activity. To analyze the effect of Tsd‐G on the pharmacokinetics of paclitaxel (PTX), researchers selected 30 Sprague–Dawley (SD) rats, randomized into a solvent control group, a verapamil positive control group, and 20, 40, and 60 mg/kg Tsd‐G groups. After seven consecutive days of intraperitoneal injection of verapamil or Tsd‐G, a single dose of 6 mg/kg PTX was injected intravenously. Plasma samples were collected at different time points, and proteins were precipitated using a methanol–acetonitrile solution. An ultrahigh‐performance liquid chromatography–tandem mass spectrometry method was developed, with docetaxel as an internal standard, and quantified using positive ion multiple reaction monitoring (MRM) mode. This analytical method's specificity, accuracy, precision, recovery, matrix effect, and sample stability meet the requirements for biological sample determination. After Tsd‐G administration in rats, the mean residence time of PTX was significantly prolonged. And Tsd‐G can stably bind to P‐gp by forming hydrogen bonds and inhibiting the expression of P‐gp in rat liver. Although the metabolites of PTX were not detected in this study, the above results still indicate the existence of HDIs between Tsd‐G and PTX, and P‐gp may be the main target to mediate HDIs.
Is deep brain imaging on the brink of transformation with a bioluminescence molecule?
Authors: Xu Shumao , Manshaii Farid , Chen Jun 
Published: August 2024

AbstractCephalofurimazine (CFz), when paired with Antares luciferase, shows superior blood‐brain barrier permeability and enhanced imaging depth and clarity for deep brain imaging. This bioluminescence provides a less invasive method for real‐time monitoring of deep brain activity, with the potential to advance targeted therapies and deepen our understanding of brain functions. Further molecular engineering and localized delivery can reduce the potential toxicity of CFz and enhance its efficacy for clinical deep brain imaging.
Music therapy for depression: A narrative review
Authors: Wang Xiaoman , Huang Wei , Liu Shuibin , He Chunhua , Wu Heng , Cheng Lianglun , Deng Songqing 
Published: August 2024

AbstractAs living standards improve, mental and physical health have been gaining increasing attention. Presently, depression is one of the most severe mental health issues. Depression affects the quality of life of affected individuals because it lasts for a very long time and is generally difficult to cure. Currently, pharmacotherapy and psychotherapy are the two main approaches for treating depression. However, some principles and characteristics of pharmacotherapy remain unclear, and its side effects are significant and noticeable. In addition, ordinary psychotherapy requires the assistance of a qualified psychotherapist, which is usually hard to find and expensive. Both methods are burdensome to the patients, making it difficult for them to benefit. As an easy‐to‐obtain therapy, music therapy has been recommended by physicians as an auxiliary therapy for various diseases to regulate patients' emotions and help the primary treatment methods to obtain better therapeutic effects. This review investigates and summarizes recent articles on the pathogenesis of depression and the effects of music therapy on depression. Its results show that music therapy is effective and available. However, a systematic treatment plan has not yet been formulated due to the lack of samples and short follow‐up times. Future studies should include more samples and follow‐up patients after the treatment period to address the continuous effect and principle of music therapy.
Remote proctoring during structural heart procedures: Toward a widespread diffusion of knowledge using mixed reality
Authors: Ascione Guido , Rossini Giovanni , Schiavi Davide , Azzola Guicciardi Nicolò , Saccocci Matteo , Buzzatti Nicola , Godino Cosmo , Alfieri Ottavio , Agricola Eustachio , Maisano Francesco , Denti Paolo 
Published: August 2024

AbstractBackgroundDespite its wide diffusion in surgical procedures, very few experiences are reported so far about the possible applications of remote proctoring (RP) in structural heart interventions.AimsOur aim was to demonstrate the feasibility, safety, and efficacy of RP during transcatheter edge‐to‐edge repair using a mixed reality‐based head‐mounted display (HMD).MethodsTwo users (a doctor and a proctor), wearing HMDs, were connected through a 5G network, allowing them to share audio and video signals. During the procedure, the proctor was located in a contiguous room, without any direct connection with the operator. The primary endpoint was noninferiority of HMD‐mediated interaction if compared with direct in‐person interaction. It was assessed using an operator−proctor interaction test based on six questions asked by the doctor to the proctor on six key procedural steps.ResultsBetween September 2021 and April 2022, nine patients were enrolled in the study (15 clips delivered). The primary endpoint was reached in 9/15 clips implanted (60%). The first three failures were due to a chat software problem, and the others were linked with a 5G network malfunction. However, the HMD and its mixed reality tools were well tolerated by the operators, and no interference with the procedure was registered in any of the cases.ConclusionsIn our experience, RP during structural heart interventions is feasible and efficacious. Wearing the HMD is comfortable and does not affect safety and effectiveness of interventional procedures. However, especially if considering a wide geographic use of this tool, a stable internet connection is imperative.
Shark fin sign: A rare EKG finding in a patient with Takotsubo cardiomyopathy from influenza A infection
Authors: Wattanachayakul Phuuwadith , Jones Colton , Malin John , Mohan Nandakumar , Manzano Jose Martinez , Akuna Emmanuel , Amanullah Aman 
Published: August 2024

Key Clinical MessageThis case demonstrated the rare “shark fin” ECG pattern, an ST‐segment elevation typically seen in acute myocardial infarction. We reported a case of takotsubo cardiomyopathy secondary to influenza A infection with multiple organ failure, showing the shark fin sign and resulting in in‐patient mortality and various complication.
Giant left main stem aneurysm in a patient with non‐sustained ventricular tachycardia: A case report
Authors: Erdem Saliha , Damlakhy Ahmad , Kanwar Amrit , Dayco John , Lieberman Randy 
Published: August 2024

Key Clinical MessageIt is important to maintain a vigilant approach towards incidental, rare findings like coronary artery aneurysms (CAAs) presenting with arrhythmia, particularly in patients with a history of myocardial infarction and cardiovascular risk factors. Diagnosis needs thorough evaluation. Tailoring management strategies to individual patient characteristics is crucial for optimizing outcomes.
Diverse Catalytic Applications of Phosphine Oxide‐Based Metal Complexes
Authors: Vijai Anand A. S. , Perinbanathan S. , Singh Indresh , Panicker Rakesh R , Boominathan T. , Gokul A. S. , Sivaramakrishna Akella 
Published: August 2024

AbstractPhosphine oxides are an interesting class of compounds possessing tetracoordinate and pentavalent phosphorus atoms and have been employed in a wide range of applications including reagents in organic synthesis, metal extractants, flame retardants, pharmaceuticals, and bioactivity studies. Among all, the degree of basicity of phosphoryl oxygen driven by the nature of substituents influences the electronic properties of the central metal in a complex toward the diversified catalytic processes. Further, the presence of heteroatoms adjacent to the central phosphorus atom enhances the nucleophilicity of the phosphoryl oxygen atom. In view of this, the present review covers the past two decades of remarkable catalytic versatility of P=O‐based metal complexes and describes the governing factors influencing the structural properties and the resultant coordination behavior. Interestingly, some of the P=O bond distances of metal complexes are either longer or shorter compared to their free ligands, indicating the catalytic activity. These complexes can effectively catalyze a wide range of chemical reactions including polymerizations, C−C and Si−C bond activations, oxidation, reduction, hydroformylation, hydrophosphination, hydrogenation and cyclization reactions. Furthermore, this review emphasizes the impact of substituents, solvents, additives, light, and temperature on the catalytic efficiency.
Reversibility in Structural Dynamics on Pt−Ni Bimetallic Nanocrystals under Redox Conditions
Authors: Song Yejin , Kim Taek‐Seung , Kim Daeho , Han Jaebeom , Lee Han‐Koo , Park Jeong Young 
Published: August 2024

AbstractThe reversibility of structural change in a bimetallic catalyst during the chemical reaction is an essential factor to determine the catalytic stability. Herein, we investigate the surface modulation of three Pt−Ni bimetallic alloy nanoparticle compositions (Pt3Ni1, Pt1Ni1, and Pt1Ni3) under alternating redox cycles. We validate trends in the structural change of the three compositions of Pt−Ni nanoparticles via spectroscopic/microscopic investigations at bulk and atomic levels. Pt‐rich Pt−Ni nanoparticles exhibited higher reversibility in structural change during the repeated redox cycles. On the contrary, Ni‐rich Pt−Ni nanoparticles showed irreversible structural changes, leading to the segregation and separation of Ni species from the alloy, which could deactivate the catalysts. This work demonstrates the reversibility of structural dynamics in alloy catalysts depending on their composition, providing fundamental insights for developing ideal bimetallic catalysts.
Psychological Interventions for PTSD, Depression, and Anxiety in Child, Adolescent and Adult Forced Migrants: A Systematic Review and Frequentist and Bayesian Meta‐Analyses
Authors: Molendijk Marc , Baart Charlotte , Schaffeld Jan , Akçakaya Zeynep , Rönnau Charlotte , Kooistra Marike , de Kleine Rianne , Strater Celina , Mooshammer Louise 
Published: August 2024

ABSTRACTObjectiveThe number of forced migrants has been rising for years. Many forced migrants suffer from post‐traumatic stress disorder (PTSD), depression, and/or anxiety and need treatment. Here, we evaluate the effectiveness of psychological interventions (CBT, EMDR, expressive/art, mindfulness, mixed elements, NET and psychoeducation) in reducing symptoms of PTSD, depression, and anxiety in forced migrants.Design and Data SourcesSystematic searches in PubMed and Web of Science and searches of preprint servers and grey literature were performed (final search date: 1 September 2023). Random‐effects frequentist and Bayesian meta‐analyses were used for data synthesis.ResultsWe included 84 studies on treatment effects in adults (pooled N = 6302) and 32 on children and adolescents (pooled N = 1097). Our data show a reduction in symptoms of PTSD, depression and anxiety symptoms in both adults and child/adolescent forced migrants. Pooled pre‐ to post‐treatment effects (effect size Cohen's d) ranged from −1.03 to −0.26 for PTSD, from −0.91 to −0.11 for depression and from −0.91 to −0.60 for anxiety, without there being differences in outcome per study design (i.e., RCT comparison vs. non‐RCT comparison vs. single arm treatment study). Treatment effects remained evident over follow‐up, and not a single type of treatment stood out as being superior to other treatment types. Structural differences in populations (e.g., regarding country of origin) over studies, however, could have hampered the validity of the comparisons between study characteristics such as treatment type.ConclusionOur findings support the effectiveness of psychological treatment in adult and child/adolescent forced migrants.
Jump resonance in the driven Chua's circuit to design frequency selective devices
Authors: Buscarino Arturo , Famoso Carlo , Fortuna Luigi 
Published: August 2024

AbstractThe onset of jump resonance in the driven Chua's circuit is deeply described in this paper, further confirming the role of Chua's circuit in nonlinear circuits and systems theory. The study of the conditions under which this peculiar behavior occurs is based on the possibility of obtaining a Lur'e representation of the driven Chua's circuit and applying the describing function approach. Design considerations to select the Chua's circuit parameters in order to shape the jump resonance features are given, providing the nonlinear core for highly selective frequency drift sensors.
Liver regeneration after injury: Mechanisms, cellular interactions and therapeutic innovations
Authors: Liu Qi , Wang Senyan , Fu Jing , Chen Yao , Xu Jing , Wei Wenjuan , Song Hao , Zhao Xiaofang , Wang Hongyang 
Published: August 2024

AbstractThe liver possesses a distinctive capacity for regeneration within the human body. Under normal circumstances, liver cells replicate themselves to maintain liver function. Compensatory replication of healthy hepatocytes is sufficient for the regeneration after acute liver injuries. In the late stage of chronic liver damage, a large number of hepatocytes die and hepatocyte replication is blocked. Liver regeneration has more complex mechanisms, such as the transdifferentiation between cell types or hepatic progenitor cells mediated. Dysregulation of liver regeneration causes severe chronic liver disease. Gaining a more comprehensive understanding of liver regeneration mechanisms would facilitate the advancement of efficient therapeutic approaches. This review provides an overview of the signalling pathways linked to different aspects of liver regeneration in various liver diseases. Moreover, new knowledge on cellular interactions during the regenerative process is also presented. Finally, this paper explores the potential applications of new technologies, such as nanotechnology, stem cell transplantation and organoids, in liver regeneration after injury, offering fresh perspectives on treating liver disease.
High‐throughput screen to identify and optimize NOT gate receptors for cell therapy
Authors: Martire S. , Wang X. , McElvain M. , Suryawanshi V. , Gill T. , DiAndreth B. , Lee W. , Riley T. P. , Xu H. , Netirojjanakul C. , Kamb A. 
Published: August 2024

AbstractLogic‐gated engineered cells are an emerging therapeutic modality that can take advantage of molecular profiles to focus medical interventions on specific tissues in the body. However, the increased complexity of these engineered systems may pose a challenge for prediction and optimization of their behavior. Here we describe the design and testing of a flow cytometry‐based screening system to rapidly select functional inhibitory receptors from a pooled library of candidate constructs. In proof‐of‐concept experiments, this approach identifies inhibitory receptors that can operate as NOT gates when paired with activating receptors. The method may be used to generate large datasets to train machine learning models to better predict and optimize the function of logic‐gated cell therapeutics.
Pitfalls in Cytological Diagnosis of Extra Adrenal Paraganglioma and Pheochromocytoma: Experience From a Tertiary Care Center
Authors: Mukherjee Raktim , Dey Soumya , Khatun Farjana , Sk Firdous Wasim , Das Oindrila , Sarkar Debansu , Maiti Krishnendu , Chatterjee Uttara 
Published: August 2024

ABSTRACTBackgroundPheochromocytoma and extra‐adrenal paragangliomas increasingly coming into light nowadays because of improved imaging techniques and biochemical investigations. There is sparse literature available regarding cytological findings of adrenal and extra‐adrenal paragangliomas.Material and MethodsWe studied 16 cytological specimens retrospectively over a period of 3 years, where subsequent histological diagnosis of phaeochromocytoma or paraganglioma was available.ResultsA total of 16 cytology specimens were studied. Nine patients had adrenal SOLs and seven patients had extra‐adrenal lesions. Age range was 12 to 60 years Majority of the cytology smears were cellular (87.5%). The smears were composed of small clusters as well as dispersed plasmacytoid cells with eccentric nuclei containing salt and pepper chromatin and moderate to abundant granular cytoplasm. Large cellular clusters mimicking the Zellballen pattern was present in one case. Anisonucleosis was mild to moderate, except in three cases where marked anisonucleosis posed diagnostic challenges. The background was hemorrhagic in all cases, however, two cases in addition had necroinflammatory background. All cases lacked mitotic activity and cytoplasm was delicate with indistinct cell borders. Bare oval nuclei were a frequent finding. Nuclear grooves or cytoplasmic vacuoles were absent. In 12 out of 16 cases, the initial cytological diagnosis correlated with final histological diagnosis, with an overall diagnostic accuracy of 75%. Four misdiagnosed cases had some atypical cytological features like marked anisonucleosis, necroinflammatory background, and presence of prominent nucleoli.ConclusionHere we have highlighted some of the distinguishing cytological features that can help in cytological diagnosis of paragangliomas. Hemorrhagic background with plasmacytoid morphology, granular cytoplasm, naked nuclei, and absence of mitosis are useful clues.
Extra‐Adrenal Paraganglioma on Fine‐Needle Aspiration Cytology: A Case Series
Authors: Atiq Aribah , Rafique Zubaria , Lone Ujyara Maryam , Bashir Azra , Khan Faria Waqar , Chughtai Akhtar Sohail 
Published: August 2024

ABSTRACTParagangliomas (PGs) are rare tumors that most commonly occur in the head and neck region and along the sympathetic chain. Fine‐needle aspiration cytology is not commonly used for the diagnosis of PG due to the potential risk of hemorrhage and hypertensive crisis. As a result, limited studies describe the cytological features of PGs. In this case series, we will discuss the fine‐needle aspiration features of three cases of extra‐adrenal PGs. The cellular arrangement in smears was either singly scattered or loosely cohesive clusters. The cells were polygonal with pleomorphic nuclei, abundant granular cytoplasm, and bland chromatin. Cellblock showed two types of cells with focal acinar formation. Immunohistochemistry also confirmed the diagnosis. These results were also in keeping with radiological findings. Fine‐needle aspiration cytology, along with clinicoradiological findings, can help in making an accurate preoperative diagnosis of PG.
Emerging Adults Mirror Infants’ Emotions and Yawns
Authors: Leung Tiffany S. , Zeng Guangyu , Maylott Sarah E. , Malik Arushi , Zhang Shuo , McNamara Emily C. , Jakobsen Krisztina V. , Simpson Elizabeth A. 
Published: August 2024

ABSTRACTInfants’ nonverbal expressions—a broad smile or a sharp cry—are powerful at eliciting reactions. Although parents’ reactions to their own infants’ expressions are relatively well understood, here we studied whether adults more generally exhibit behavioral and physiological reactions to unfamiliar infants producing various expressions. We recruited U.S. emerging adults (N = 84) prior to parenthood, 18–25 years old, 68% women, ethnically (20% Hispanic/Latino) and racially (7% Asian, 13% Black, 1% Middle Eastern, 70% White, 8% multiracial) diverse. They observed four 80‐s audio–video clips of unfamiliar 2‐ to 6‐month‐olds crying, smiling, yawning, and sitting calmly (emotionally neutral control). Each compilation video depicted 9 different infants (36 clips total). We found adults mirrored behaviorally and physiologically: more positive facial expressions to infants smiling, and more negative facial expressions and pupil dilation—indicating increases in arousal—to infants crying. Adults also yawned more and had more pupil dilation when observing infants yawning. Together, these findings suggest that even nonparent emerging adults are highly sensitive to unfamiliar infants’ expressions, which they naturally “catch” (i.e., behaviorally and physiologically mirror), even without instructions. Such sensitivity may have—over the course of humans’ evolutionary history—been selected for, to facilitate adults’ processing of preverbal infants’ expressions to meet their needs.