bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiation effects in biological systems
Authors: Symons Martyn C. R. 
Published: October 2015

SynopsisThis paper presents a chemist's view of the action of ionising radiation on matter with a range of simple examples. Attention is given to the ways in which electron spin resonance spectroscopy (which is described briefly) can be harnessed to give useful information about the initial stages of radiation damage. The effects of radiation are generally indiscriminate and hence damage to water is of special importance in biological systems. Water-derived free radicals will attack biomolecules (the indirect effect) and this mechanism is compared with direct damage events. Also, examples are given of some remarkably discriminate radiation-induced reactions.Specific attention is given to radiation-induced damage to proteins, and especially to aqueous DNA and DNA in chromatin and in cells. The importance of DNA strand-breaks is discussed in relation to both the production of mutations and cell death.
Neuropeptides in Eating Disorders
Authors: Jimerson David C. , Wolfe Barbara E. 
Published: October 2015

AbstractThe past decade has witnessed a dramatic acceleration in research on the role of the neuropeptides in the regulation of eating behavior and body weight homeostasis. This expanding research focus has been driven in part by increasing public health concerns related to obesity and the eating disorders anorexia nervosa (AN) and bulimia nervosa (BN). Preclinical advances have been facilitated by the development of new molecular and behavioral research methodologies. With a focus on clinical investigations in AN and BN, this article reviews research on selected hypothalamic and gut-related peptide systems with prominent effects on eating behavior. Studies of the orexigenic peptides neuropeptide Y and the opioid peptides have shown state-related abnormalities in patients with eating disorders. With respect to gut-related peptides, there appears to be substantial evidence for blunting in the meal-related release of the satiety promoting peptide cholecystokinin in BN. Fasting plasma levels of the orexigenic peptide ghrelin have been found to be elevated in patients with AN. As discussed in this review, additional studies will be needed to assess the role of nutritional and body weight changes in neuropeptide alterations observed in symptomatic eating disorder patients, and to identify stable trait-related abnormalities in neuropeptide regulation that persist in individuals who have recovered from an eating disorder.
Efficacy Comparison of Escitalopram and Citalopram in the Treatment of Major Depressive Disorder: Pooled Analysis of Placebo-Controlled Trials
Authors: Gorman Jack M. , Korotzer Andrew , Su Guojin 
Published: October 2015

ABSTRACTBackground:Citalopram is a racemic selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of depression. Citalopram is a racemate and its serotonin reuptake inhibitory activity resides primarily in the single S-isomer, escitalopram, which is now being evaluated for its potential usefulness in the treatment of depression and other psychiatric disorders. Results from placebo-controlled studies that also included Citalopram as an active control have shown that escitalopram is effective in treating depression and associated symptoms of anxiety. However, none of these studies was powered sufficiently to detect differences between active treatment groups. The goal of the present analysis is to evaluate the efficacy of escitalopram compared with Citalopram in the treatment of major depressive disorder.Method:Data were pooled from three similarly designed, randomized, double-blind, placebo-controlled trials of escitalopram (10–20 mg/day) and Citalopram (20–40 mg/day). Patients were male or female, ≥18 years of age, who met criteria for a major depressive episode with a Montgomery Asberg Depression Rating Scale (MADRS) score ≥22 at baseline. Efficacy measures included change from baseline in MADRS score and the Clinical Global Impression of Improvement (CGI-I) scale. Improvement in associated symptoms of anxiety was measured using the change from baseline in the MADRS inner tension item.Results:Both escitalopram and Citalopram significantly improved depression and anxiety symptoms compared with placebo, and there were significantly more MADRS responders (defined as ≥50% improvement in MADRS scores at end point) in the escitalopram and Citalopram treatment groups. Escitalopram treatment was associated with statistically significant improvements in all efficacy measures relative to placebo after 1 week of treatment, whereas Citalopram treatment statistically separated from placebo at the end of week 4 (CGI-I and MADRS inner tension) or week 6 (MADRS). Escitalopram treatment also was statistically significantly superior to Citalopram treatment at a number of time points.Conclusion:These data support the effectiveness of escitalopram and Citalopram in the treatment of major depressive disorder, and suggest escitalopram may have a faster onset and greater overall magnitude of effect than citalopram in improving symptoms of depression and anxiety in patients with major depressive disorder.
“The trouble with QALYs…”
Authors: Knapp Martin , Mangalore Roshni 
Published: October 2015

AbstractThis paper summarises the use of QALYs in evaluating changes in mental health states, highlighting the benefits and challenges of their use in this field. The general principles underlying the QALY measure and the most common methods of measuring QALYs are discussed briefly. Evidence of the usefulness and problems of using this generic measure of health-related quality of life are provided from a sample of recent studies relating to depression, schizophrenia, attention deficit hyperactivity disorder and dementia. In each case, attempts were made to use QALYs to measure changes in health states. While in principle, the QALY is enormously attractive, its suitability for measuring changes in many mental health conditions remains open to doubt as existing tools for generating QALY scores such as the EQ-5D have tended not to perform sufficiently well in reflecting changes in many mental health states. New developmental work is needed to construct better QALY-measuring tools for use in the mental health field. Both the conceptualisation and measurement of QALYs need to be built on a valid, comprehensive model of quality of life specific to a mental health disorder, to ensure that the resultant tool is sensitive enough to pick up changes that would be expected and seen as relevant in the course of the illness.
Drought susceptibility of modern rice varieties: an effect of linkage of drought tolerance with undesirable traits
Authors: Vikram Prashant , Swamy B. P. Mallikarjuna , Dixit Shalabh , Singh Renu , Singh Bikram P. , Miro Berta , Kohli Ajay , Henry Amelia , Singh N. K. , Kumar Arvind 
Published: October 2015

AbstractGreen Revolution (GR) rice varieties are high yielding but typically drought sensitive. This is partly due to the tight linkage between the loci governing plant height and drought tolerance. This linkage is illustrated here through characterization of qDTY1.1, a QTL for grain yield under drought that co-segregates with the GR gene sd1 for semi-dwarf plant height. We report that the loss of the qDTY1.1 allele during the GR was due to its tight linkage in repulsion with the sd1 allele. Other drought-yield QTLs (qDTY) also showed tight linkage with traits rejected in GR varieties. Genetic diversity analysis for 11 different qDTY regions grouped GR varieties separately from traditional drought-tolerant varieties and showed lower frequency of drought tolerance alleles. The increased understanding and breaking of the linkage between drought tolerance and undesirable traits has led to the development of high-yielding drought-tolerant dwarf lines with positive qDTY alleles and provides new hope for extending the benefits of the GR to drought-prone rice-growing regions.
Characterization of plasma protein binding dissociation with online SPE-HPLC
Authors: Li Ping , Fan Yiran , Wang Yunlong , Lu Yaxin , Yin Zheng 
Published: October 2015

AbstractA novel parameter of relative recovery (Rre) was defined and determined by online SPE-HPLC to characterize plasma protein binding (PPB) kinetics of highly plasma binding drugs. The proportional relationship of Rre with koff of PPB has been established with a new SPE model. A rapid, easy to use method could potentially be used to categorize PK properties of the drug candidates in the decision process of drug discovery and development.
SPP2 Mutations Cause Autosomal Dominant Retinitis Pigmentosa
Authors: Liu Yuan , Chen Xue , Xu Qihua , Gao Xiang , Tam Pancy O. S. , Zhao Kanxing , Zhang Xiumei , Chen Li Jia , Jia Wenshuang , Zhao Qingshun , Vollrath Douglas , Pang Chi Pui , Zhao Chen 
Published: October 2015

AbstractRetinitis pigmentosa (RP) shows progressive loss of photoreceptors involved with heterogeneous genetic background. Here, by exome sequencing and linkage analysis on a Chinese family with autosomal dominant RP, we identified a putative pathogenic variant, p.Gly97Arg, in the gene SPP2, of which expression was detected in multiple tissues including retina. The p.Gly97Arg was absent in 800 ethnically matched chromosomes and 1400 in-house exome dataset and was located in the first of the two highly conserved disulfide bonded loop of secreted phosphoprotein 2 (Spp-24) encoded by SPP2. Overexpression of p.Gly97Arg and another signal peptide mutation, p.Gly29Asp, caused cellular retention of both endogenous wild type and exogenous mutants in vitro and primarily affected rod photoreceptors in zebrafish mimicking cardinal feature of RP. Taken together, our data indicate that the two mutations of SPP2 have dominant negative effects and cellular accumulation of Spp-24 might be particularly toxic to photoreceptors and/or retinal pigment epithelium. SPP2 has a new role in retinal degeneration.
Sequence-specific RNA Photocleavage by Single-stranded DNA in Presence of Riboflavin
Authors: Zhao Yongyun , Chen Gangyi , Yuan Yi , Li Na , Dong Juan , Huang Xin , Cui Xin , Tang Zhuo 
Published: October 2015

AbstractConstant efforts have been made to develop new method to realize sequence-specific RNA degradation, which could cause inhibition of the expression of targeted gene. Herein, by using an unmodified short DNA oligonucleotide for sequence recognition and endogenic small molecue, vitamin B2 (riboflavin) as photosensitizer, we report a simple strategy to realize the sequence-specific photocleavage of targeted RNA. The DNA strand is complimentary to the target sequence to form DNA/RNA duplex containing a G•U wobble in the middle. The cleavage reaction goes through oxidative elimination mechanism at the nucleoside downstream of U of the G•U wobble in duplex to obtain unnatural RNA terminal and the whole process is under tight control by using light as switch, which means the cleavage could be carried out according to specific spatial and temporal requirements. The biocompatibility of this method makes the DNA strand in combination with riboflavin a promising molecular tool for RNA manipulation.
Mechanically Flexible and High-Performance CMOS Logic Circuits
Authors: Honda Wataru , Arie Takayuki , Akita Seiji , Takei Kuniharu 
Published: October 2015

AbstractLow-power flexible logic circuits are key components required by the next generation of flexible electronic devices. For stable device operation, such components require a high degree of mechanical flexibility and reliability. Here, the mechanical properties of low-power flexible complementary metal–oxide–semiconductor (CMOS) logic circuits including inverter, NAND and NOR are investigated. To fabricate CMOS circuits on flexible polyimide substrates, carbon nanotube (CNT) network films are used for p-type transistors, whereas amorphous InGaZnO films are used for the n-type transistors. The power consumption and voltage gain of CMOS inverters are <500 pW/mm at Vin = 0 V (<7.5 nW/mm at Vin = 5 V) and >45, respectively. Importantly, bending of the substrate is not found to cause significant changes in the device characteristics. This is also observed to be the case for more complex flexible NAND and NOR logic circuits for bending states with a curvature radius of 2.6 mm. The mechanical stability of these CMOS logic circuits makes them ideal candidates for use in flexible integrated devices.
Photothermally driven fast responding photo-actuators fabricated with comb-type hydrogels and magnetite nanoparticles
Authors: Lee Eunsu , Kim Dowan , Kim Haneul , Yoon Jinhwan 
Published: October 2015

AbstractTo overcome the slow kinetics of the volume phase transition of stimuli-responsive hydrogels as platforms for soft actuators, thermally responsive comb-type hydrogels were prepared using synthesized poly(N-isopropylacrylamide) macromonomers bearing graft chains. Fast responding light-responsive hydrogels were fabricated by combining a comb-type hydrogel matrix with photothermal magnetite nanoparticles (MNP). The MNPs dispersed in the matrix provide heat to stimulate the volume change of the hydrogel matrix by converting absorbed visible light to thermal energy. In this process, the comb-type hydrogel matrix exhibited a rapid response due to the free, mobile grafted chains. The comb-type hydrogel exhibited significantly enhanced light-induced volume shrinkage and rapid recovery. The comb-type hydrogels containing MNP were successfully used to fabricate a bilayer-type photo-actuator with fast bending motion.
Four novel algal virus genomes discovered from Yellowstone Lake metagenomes
Authors: Zhang Weijia , Zhou Jinglie , Liu Taigang , Yu Yongxin , Pan Yingjie , Yan Shuling , Wang Yongjie 
Published: October 2015

AbstractPhycodnaviruses are algae-infecting large dsDNA viruses that are widely distributed in aquatic environments. Here, partial genomic sequences of four novel algal viruses were assembled from a Yellowstone Lake metagenomic data set. Genomic analyses revealed that three Yellowstone Lake phycodnaviruses (YSLPVs) had genome lengths of 178,262 bp, 171,045 bp and 171,454 bp, respectively and were phylogenetically closely related to prasinoviruses (Phycodnaviridae). The fourth (YSLGV), with a genome length of 73,689 bp, was related to group III in the extended family Mimiviridae comprising Organic Lake phycodnaviruses and Phaeocystis globosa virus 16 T (OLPG). A pair of inverted terminal repeats was detected in YSLPV1, suggesting that its genome is nearly complete. Interestingly, these four putative YSL giant viruses also bear some genetic similarities to Yellowstone Lake virophages (YSLVs). For example, they share nine non-redundant homologous genes, including ribonucleotide reductase small subunit (a gene conserved in nucleo-cytoplasmic large DNA viruses) and Organic Lake virophage OLV2 (conserved in the majority of YSLVs). Additionally, putative multidrug resistance genes (emrE) were found in YSLPV1 and YSLPV2 but not in other viruses. Phylogenetic trees of emrE grouped YSLPVs with algae, suggesting that horizontal gene transfer occurred between giant viruses and their potential algal hosts.
Nonerythropoietic Erythropoietin-Derived Peptide Suppresses Adipogenesis, Inflammation, Obesity and Insulin Resistance
Authors: Liu Yuqi , Luo Bangwei , Shi Rongchen , Wang Jinsong , Liu Zongwei , Liu Wei , Wang Shufeng , Zhang Zhiren 
Published: October 2015

AbstractErythropoietin (EPO) has been identified as being crucial for obesity modulation; however, its erythropoietic activity may limit its clinical application. EPO-derived Helix B-surface peptide (pHBSP) is nonerythrogenic but has been reported to retain other functions of EPO. The current study aimed to evaluate the effects and potential mechanisms of pHBSP in obesity modulation. We found that pHBSP suppressed adipogenesis, adipokine expression and peroxisome proliferator-activated receptor γ (PPARγ) levels during 3T3-L1 preadipocyte maturation through the EPO receptor (EPOR). In addition, also through EPOR, pHBSP attenuated macrophage inflammatory activation and promoted PPARγ expression. Furthermore, PPARγ deficiency partly ablated the anti-inflammatory activity of pHBSP in macrophages. Correspondingly, pHBSP administration to high-fat diet (HFD)-fed mice significantly improved obesity, insulin resistance (IR) and adipose tissue inflammation without stimulating hematopoiesis. Therefore, pHBSP can significantly protect against obesity and IR partly by inhibiting adipogenesis and inflammation. These findings have therapeutic implications for metabolic disorders, such as obesity and diabetes.
Cystathionine β-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia
Authors: Vellecco Valentina , Mancini Antonio , Ianaro Angela , Calderone Vincenzo , Attanasio Chiara , Cantalupo Anna , Andria Barbara , Savoia Gennaro , Panza Elisabetta , Di Martino Antonietta , Cirino Giuseppe , Bucci Mariarosaria 
Published: October 2015

Hydrogen sulfide is an endogenous gasotransmitter and its mechanism of action involves activation of ATP-sensitive K+ channels and phosphodiesterase inhibition. As both mechanisms are potentially involved in malignant hyperthermia (MH), in the present study we addressed the involvement of the L-cysteine/hydrogen sulfide pathway in MH. Skeletal muscle biopsies obtained from 25 MH-susceptible (MHS) and 56 MH-negative (MHN) individuals have been used to perform the in vitro contracture test (IVCT). Quantitative real-time PCR (qPCR) and Western blotting studies have also been performed. Hydrogen sulfide levels are measured in both tissue samples and plasma. In MHS biopsies an increase in cystathionine β-synthase (CBS) occurs, as both mRNA and protein expression compared with MHN biopsies. Hydrogen sulfide biosynthesis is increased in MHS biopsies (0.128±0.12 compared with 0.943±0.13 nmol/mg of protein per min for MHN and MHS biopsies, respectively; P&lt;0.01). Addition of sodium hydrosulfide (NaHS) to MHS samples evokes a response similar, in the IVCT, to that elicited by either caffeine or halothane. Incubation of MHN biopsies with NaHS, before caffeine or halothane challenge, switches an MHN to an MHS response. In conclusion we demonstrate the involvement of the L-cysteine/hydrogen sulfide pathway in MH, giving new insight into MH molecular mechanisms. This finding has potential implications for clinical care and could help to define less invasive diagnostic procedures.
The monstrosity of the multitude: unredeeming radical theology
Authors: Bray Karen 
Published: October 2015

AbstractIf its power comes from the very value held so dear by neoliberalism—that of productivity—can the “multitude” as conceived by Michael Hardt and Antonio Negri ever fully resist the neoliberal Empire? Engaging the Autonomous Marxism of Franco “Bifo” Berardi, I argue that continued philosophical and theological emphases on productivity resonate with a soteriological narrative embedded in neoliberalism’s promise that work is redemptive. As both counter and supplement to such emphases, this essay offers an alternate reading of Hardt and Negri’s multitude through the lens of crip (disability) theory. In Sex and Disability crip theorists Anna Mollow and Robert McRuer argue that counter to Joseph Conrad’s assertion that “ ‘A man is a worker. If he is not then he is nothing,’ ” a crip politics says, “fuck employability: I’m too sick to work” (25). To embrace the stigma of sickness is to question the demands of productive labour on offer by society. A similar crip politics, one that tells the Empire it is too sick to work and too slow to be efficient, might loose the multitude from its redeployment in the very technologies of power Hardt and Negri hope to counter. Looking to figures of monstrosity, I argue that productivist tendencies within radical theology betray the field’s crip potential. Ultimately, this essay seeks to recover the multitude’s monstrosity from within Hardt and Negri’s corpus. A return to its monstrosity returns the multitude to its unproductive potency, that which wanders away from demands of social cohesion, and thus resists redemptive wholeness. This article is published as part of a collection dedicated to radical theologies.
Effect of infrastructure design on commons dilemmas in social−ecological system dynamics
Authors: Yu David J. , Qubbaj Murad R. , Muneepeerakul Rachata , Anderies John M. , Aggarwal Rimjhim M. 
Published: October 2015

Significance
Recent years have witnessed an explosion of interdisciplinary research on social−ecological systems (SESs), which has typically viewed SESs as self-organized systems. This view, however, may be incomplete in that many modern SESs are in fact part designed and part self-organized, i.e., the coupled processes in most SESs are mediated by consciously designed infrastructure. We examined how design features of infrastructure shape the long-term dynamics of SESs, using a model of an irrigation system (an exemplary case of a partly designed SES). We show that two design features common to many SESs—the structure of benefit flows and the scale of effort needed to maintain infrastructure—can induce fundamental changes in qualitative behavior as well as altered robustness characteristics.
Historical dynamics in ecosystem service bundles
Authors: Renard Delphine , Rhemtulla Jeanine M. , Bennett Elena M. 
Published: October 2015

Significance
Most approaches to quantifying and mapping ecosystem services (ES) focus on a single point in time. This static approach cannot provide insight into whether and how the provision of ES changes through time. We examined spatiotemporal ES dynamics by reconstructing the regional provision of nine ES over 35 y. Our approach demonstrated that individual services, ES bundles, and interactions among ES changed across both time and space. We also identified trajectories of ES bundle change and explained how these changes were driven by policy, biophysical, and socioeconomic characteristics. Our study demonstrates the limitations of assuming stationarity in ES and their relationships, and emphasizes the importance of taking into account both time and space in the assessment of multiple ES.
Topological framework for local structure analysis in condensed matter
Authors: Lazar Emanuel A. , Han Jian , Srolovitz David J. 
Published: October 2015

Significance
Richard Feynman famously described the hypothesis “All things are made of atoms” as among the most significant of all scientific knowledge. How atoms are arranged in “things” is an interesting and natural question. However, aside from perfect crystals and ideal gases, understanding these arrangements in an insightful yet tractable manner is challenging. We introduce a unified mathematical framework for classifying and identifying local structure in imperfect condensed matter systems using Voronoi topology. This versatile approach enables visualization and analysis of a wide range of complex atomic systems, including highly defected solids and glass-forming liquids. The proposed framework presents a new perspective into the structure of discrete systems of particles, ordered and disordered alike.
Habitual control of goal selection in humans
Authors: Cushman Fiery , Morris Adam 
Published: October 2015

Significance
Human cognition makes widespread use of goal-directed planning. However, exhaustive forward planning for tasks of real-world complexity is prohibitively computationally demanding. Much research aims to find efficient mechanisms for approximate planning. We describe an approach to this problem that exploits the computational efficiency of habit learning to select goal states that are subsequently used in planning. We also provide experimental evidence that humans implement this approach. Our findings illuminate the basis of learning and choice in humans, demonstrate an integration between mechanisms of habitual and planned control, and contribute to the development of computationally tractable planning algorithms.