bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiosarcoma: clinical outcomes and prognostic factors, a single-center analysis
Authors: Roohani Siyer , Rotermund Titus , Ehret Felix , Dziodzio Tomasz , Jarosch Armin , Schäfer Frederik Maximilian , Flörcken Anne , Wittenberg Silvan , Zips Daniel , Kaul David 
Published: June 2024

Abstract
Purpose
This study sought to investigate oncological outcomes and prognostic factors for patients with angiosarcomas (AS).

Methods
This single-center, retrospective cohort study, analyzed histopathologically confirmed AS cases. Primarily diagnosed, locally recurrent and metastatic AS were included. Overall survival (OS), local control (LC) and local progression-free survival (LPFS) were assessed by Kaplan-Meier estimator. Multivariable Cox regression analysis was performed to detect factors associated with OS and LPFS.

Results
In total, 118 patients with a median follow-up of 6.6 months were included. The majority presented with localized disease (62.7%), followed by metastatic (31.4%) and locally recurrent (5.9%) disease. Seventy-four patients (62.7%) received surgery, of which 29 (39.2%) were treated with surgery only, 38 (51.4%) with surgery and perioperative radiotherapy or chemotherapy, and 7 (9.4%) with surgery, perioperative radiotherapy and chemotherapy. Multivariable Cox regression of OS showed a significant association with age per year (hazard ratio (HR): 1.03, p = 0.044) and metastatic disease at presentation (hazard ratio: 3.24, p = 0.015). For LPFS, age per year (HR: 1.04, p = 0.008), locally recurrent disease at presentation (HR: 5.32, p = 0.013), and metastatic disease at presentation (HR: 4.06, p = 0.009) had significant associations. Tumor size, epithelioid components, margin status, and perioperative RT and/or CTX were not significantly associated with OS or LPFS.

Conclusion
Older age and metastatic disease at initial presentation status were negatively associated with OS and LPFS. Innovative and collaborative effort is warranted to overcome the epidemiologic challenges of AS by collecting multi-institutional datasets, characterizing AS molecularly and identifying new perioperative therapies to improve patient outcomes.
The definitions, assessment, and dimensions of cancer-related fatigue: A scoping review
Authors: Keane Kayla F. , Wickstrom Jordan , Livinski Alicia A. , Blumhorst Catherine , Wang Tzu-fang , Saligan Leorey N. 
Published: June 2024

Abstract
Purpose
Cancer-related fatigue (CRF) is challenging to diagnose and manage due to a lack of consensus on its definition and assessment. The objective of this scoping review is to summarize how CRF has been defined and assessed in adult patients with cancer worldwide.

Methods
Four databases (PubMed, Embase, CINAHL Plus, PsycNet) were searched to identify eligible original research articles published in English over a 10-year span (2010–2020); CRF was required to be a primary outcome and described as a dimensional construct. Each review phase was piloted: title and abstract screening, full-text screening, and data extraction. Then, two independent reviewers participated in each review phase, and discrepancies were resolved by a third party.

Results
2923 articles were screened, and 150 were included. Only 68% of articles provided a definition for CRF, of which 90% described CRF as a multidimensional construct, and 41% were identical to the National Comprehensive Cancer Network definition. Studies were primarily conducted in the United States (19%) and the majority employed longitudinal (67%), quantitative (93%), and observational (57%) study designs with sample sizes ≥ 100 people (57%). Participant age and race were often not reported (31% and 82%, respectively). The most common cancer diagnosis and treatment were breast cancer (79%) and chemotherapy (80%; n = 86), respectively. CRF measures were predominantly multidimensional (97%, n = 139), with the Multidimensional Fatigue Inventory (MFI-20) (26%) as the most common CRF measure and “Physical” (76%) as the most common CRF dimension.

Conclusion
This review confirms the need for a universally agreed-upon definition and standardized assessment battery for CRF.
Age is a predictor of elbow stiffness after type III or IV supracondylar humerus fractures
Authors: Gupta Kavish , Erdman Mary Kate , Siddiqui Ali , Schur Mathew , Meisel Erin , Goldstein Rachel Y. 
Published: June 2024

Abstract
Purpose
Supracondylar humerus (SCH) fractures account for approximately 30% of injuries for those younger than 7 years of age (Cheng et al. in J Pediatr Orthop 19:344–350, 1999). Recent studies examining the association of patient age and SCH fracture outcomes have provided conflicting findings. The purpose of this study is to investigate SCH fracture outcomes in children at different ages of skeletal development.

Methods
Retrospective review of a Level I pediatric trauma center between 2010 and 2014 was conducted. 190 patients with SCH fractures, age < 14 years, fracture type Gartland III or IV (AO/OTA 13-M 3.1 III and IV) were included. Patients were sorted into age groups: < 2 years, 4–6 years, and > 8 years. Patients were treated with either a closed or open reduction with percutaneous fixation. Clinical outcomes including postoperative elbow range of motion, nerve palsy, compartment syndrome, infection, and cubitus varus were assessed.

Results
Patients in younger age groups were more likely to obtain postoperative full elbow flexion (< 2 years = 77%; 4–6 years = 66%; > 8 years = 43%) and full elbow extension (< 2 years = 96%; 4–6 years = 88%; > 8 years = 64%). Age was a significant predictor of nerve palsy on admission, mean operative time (< 2 years = 21.8 min; 4–6 years = 43.0 min; > 8 years = 80.7 min), and mean fluoroscopy time (< 2 years = 22.9 s; 4–6 years = 59.5 s; > 8 years = 171.9 s). There were no differences in rates of open reduction, compartment syndrome, pin tract infection, cubitus varus, or reoperation among groups.

Conclusion
Increasing age is associated with increased elbow stiffness after percutaneous fixation of Gartland Type III and Type IV SCH fractures. Older patients with SCH fractures may benefit from formal rehabilitation.

Level of evidence
III.
The why and how of the SynNerGe criteria of Parkinson´s disease
Authors: Höglinger Günter U. , Lang Anthony E. 
Published: June 2024

AbstractIn pursuit of early therapeutic interventions for Parkinson’s disease, the proposed SynNeurGe classification system integrates α-synuclein pathology (S), neurodegeneration evidence (N), and pathogenic gene variants (G). This approach aims to address the disease’s complexity and biological diversity. It suggests categorizing patients based on the presence or absence of α-synuclein pathology in tissues or cerebrospinal fluid, neurodegeneration indicators from specific imaging techniques, and identification of pathogenic gene variants associated with Parkinson’s disease. The proposed system emphasizes the future need for precision medicine and aims to facilitate both basic and clinical research toward disease-modifying therapies. However, the authors stress that initial implementation should be confined to research settings, considering ethical implications and current limitations. Prospective validation of these criteria is deemed necessary to ensure their efficacy and ethical application in clinical practice.
Observations and positioning quality of low-cost GNSS receivers: a review
Authors: Hamza Veton , Stopar Bojan , Sterle Oskar , Pavlovčič-Prešeren Polona 
Published: June 2024

AbstractOver the past two decades, low-cost single-frequency Global Navigation Satellite System (GNSS) receivers have been used in numerous engineering fields and applications due to their affordability and practicality. However, their main drawback has been the inability to track satellite signals in multiple frequencies, limiting their usage to short baselines only. In recent years, low-cost dual-frequency GNSS receivers equipped with Real-Time-Kinematic (RTK) engines entered the mass market, addressing many of the limitations of single-frequency GNSS receivers. This review article aimed to analyze the observations and positioning quality of low-cost GNSS receivers in different positioning methods. To provide answers to defined research questions, relevant studies on the topic were selected and investigated. From the analyzed studies, it was found that GNSS observations obtained from low-cost GNSS receivers have lower quality compared to geodetic counterparts, however, they can still provide positioning solutions with comparable accuracy in static and kinematic positioning modes, particularly for short baselines. Challenges persist in achieving high positioning accuracy over longer baselines and in adverse conditions, even with dual-frequency GNSS receivers. In the upcoming years, low-cost GNSS technology is expected to become increasingly accessible and widely utilized, effectively meeting the growing demand for positioning and navigation.
Effects of (de)motivating supervision styles on junior doctors’ intrinsic motivation through basic psychological need frustration and satisfaction: an experimental vignette study
Authors: van der Goot Wieke E. , Van Yperen Nico W. , Albers Casper J. , Jaarsma A. Debbie C. , Duvivier Robbert J. 
Published: June 2024

AbstractIn clinical practice, junior doctors regularly receive supervision from consultants. Drawing on Basic Psychological Needs Theory, consultants’ supervision styles are likely to affect junior doctors’ intrinsic motivation differently in terms of psychological need frustration and psychological need satisfaction. To examine the effects of (de)motivating supervision styles, we conducted two experimental vignette studies among junior doctors. In Study 1 (N = 150, 73.3% female), we used a 2 (need support: high vs. low) x 2 (directiveness: high vs. low) between-subjects design and, in Study 2, a within-subjects design with the same factors (N = 46, 71.7% female). Both studies revealed a consistent positive effect of need-supportive supervision styles on psychological need satisfaction (+), need frustration (-), and intrinsic motivation (+). Particularly in Study 2, the main effect of need-supportive styles was strengthened by supervisor’s directiveness. Moreover, in both studies, the effects of supervision styles on intrinsic motivation were explained through psychological need frustration and psychological need satisfaction. We discuss the implications of these findings for postgraduate clinical training.
The clinical signature of genetic variants and serum levels of macrophage migration inhibitory factor in Egyptian breast cancer patients
Authors: Seliem Mahmoud A. , Mohamadin Ahmed M. , El-Sayed Mohamed I. Kotb , Ismail Yahia , El-Husseiny Ahmed A. 
Published: June 2024

Abstract
Purpose
Macrophage migration inhibitory factor (MIF) is an integral cytokine for the modulation of both innate and adaptive immunity and is involved in the pathogenesis of various cancers. However, conflicting findings on the relationship between MIF polymorphisms and breast cancer (BC) have been reported in earlier research. We investigated the clinical value of serum MIF levels and the association between MIF rs1049829 and rs755622 variants with their serum levels and propensity to develop BC.

Methods
A total of 133 treatment-naïve Egyptian BC females and 126 apparently healthy controls were matriculated in this case–control study. The serum MIF protein levels were quantified by ELISA, whereas the genotyping was executed utilizing the TaqMan® allelic discrimination assay.

Results
A significant increase in the serum MIF level in BC cases was observed in comparison to control subjects (P < 0.0001), with a diagnostic potential to discriminate BC with 92.5% sensitivity and 73.7% specificity at a cut-off value > 9.47 ng/mL. Besides, a significant difference in serum MIF level was observed in BC cases with progesterone receptor (PR) negativity compared to those with PR positivity (P = 0.046). Moreover, a significant association was depicted between the rs1049829 variant of MIF gene and the protective effect against BC meanwhile the rs755622 variant demonstrated no significant link with BC risk.

Conclusions
This study revealed that serum MIF levels may be regarded as a promising serum tumor marker for BC. Also, the rs1049829 variant of the MIF gene is considered a protective candidate against BC.

Graphical Abstract
Foam-laid extensible paper for improved extensibility and press-forming performance
Authors: Kouko Jarmo , Tanninen Panu , Leminen Ville , Barbier Christophe , Karlsson Christopher , Pesonen Antti , Hjelt Tuomo 
Published: June 2024

AbstractThis study was motivated by the recent raising interest for the sustainable plastic-free dry 3D formable materials. 3D forming processes are capable to produce large unit quantities, but the process conditions for packaging applications have been typically very demanding for cellulose-based materials. This study covers some of the key factors affecting the extensibility of cellulose fibre-based materials and presents a laboratory-scale development study of a press-formable material concept. The investigation focused on comparisons of two refining concepts for bleached softwood kraft (BSK) pulp and two sheet forming concepts, namely water-laid and foam-laid forming. Additionally, influence of thermoplastic additives on the extensibility and 3D forming performance were investigated. In-plane compaction was applied with Expanda® laboratory device. Performance of the materials was evaluated by tensile tests and depth of the 3D formed shapes. In this study, in-plane compaction at first in cross-machine direction (CD) and then in machine direction (MD) led to over 30% elongation with BSK-based laboratory sheets containing latex as a binder and foaming agent. In addition to high elongation, optimal strength was needed for the best press-forming performances. In-plane compaction was the most significant factor regarding the elongation, but it also decreased the strength of the materials. Similar press-forming performance was found with two materials with either highly anisotropic or more isotropic elongation. The elongation anisotropy was created by one-way and two-way in-plane compactions. The results indicate that a reasonable performance for BSK-based materials for 3D forming applications can be reached using the presented concept.
Genetic diversity of phytoplasmas associated with flavescence dorée at vineyard scale on the Ischia Island (Campania, Italy)
Authors: Pierro Roberto , Barra Eleonora , Griffo Raffaele , Marcone Carmine 
Published: June 2024

AbstractFlavescence dorée (FD) is the most important grapevine yellows, constituting a great threat in all major viticultural areas in Europe. The FD causal agent is an incidentally cited phytoplasma species termed ‘Candidatus Phytoplasma vitis’ (FDp), listed as a quarantine organism in Europe and mainly transmitted from vine to vine by the monophagous leafhopper Scaphoideus titanus. In the present study, the genetic variability of FDp identified in symptomatic plants located in a vineyard cv. Biancolella on the Ischia Island (Campania, Italy) was investigated. Our results unveiled for the first time the presence of FDp strains belonging to the subgroup 16SrV–C with a low genetic variability within map and rp genetic markers, reflecting an homogeneous genetic lineage of phytoplasma population examined in the present study. Phylogeny and nucleotide sequence analyses can also suggest the possible involvement of other insect vectors and plant hosts in the FD epidemiology on the Island. Further investigation to ascertain the presence of putative vectors and plant hosts representing inoculum sources should be carried out to reinforce the preliminary results obtained in the present study.
Perspective on the description of viscoelastic flows via continuum elastic dumbbell models
Authors: Boyko Evgeniy , Stone Howard A. 
Published: June 2024

AbstractNon-Newtonian fluid mechanics and computational rheology widely exploit elastic dumbbell models such as Oldroyd-B and FENE-P for a continuum description of viscoelastic fluid flows. However, these constitutive equations fail to accurately capture some characteristics of realistic polymers, such as the steady extension in simple shear and extensional flows, thus questioning the ability of continuum-level modeling to predict the hydrodynamic behavior of viscoelastic fluids in more complex flows. Here, we present seven elastic dumbbell models, which include different microstructurally inspired terms, i.e., (i) the finite polymer extensibility, (ii) the conformation-dependent friction coefficient, and (iii) the conformation-dependent non-affine deformation. We provide the expressions for the steady dumbbell extension in shear and extensional flows and the corresponding viscosities for various elastic dumbbell models incorporating different microscopic features. We show the necessity of including these microscopic features in a constitutive equation to reproduce the experimentally observed polymer extension in shear and extensional flows, highlighting their potential significance in accurately modeling viscoelastic channel flow with mixed kinematics.
Dynamics of total and industrial energy use in Turkiye from 1991 to 2019: a case study
Authors: Rüstemoğlu Hasan 
Published: June 2024

AbstractEnergy use is an indicator of economic growth. However, high energy intensity has two main disadvantages. First, low energy efficiency increases a country’s dependence on other countries, especially when the country lacks energy sources. Second, if the country’s energy needs are met using traditional fossil fuels, this increases its CO2 emissions and reduces its air quality. Improving energy efficiency and reducing energy intensity are essential to reach the sustainability targets. This paper investigates the determinants of energy use in Turkiye for the period 1991–2019 by taking a dual approach. First, utilizing the Tapio decoupling factor, the decoupling factor analysis is not only being done for total energy use and real GDP, but also for industrial energy use and industrial income. Second, the factors determining the country’s total energy use are also examined, followed by an investigation of the indicators of energy use in the industry sector, which is highly energy intensive. For the industrial sector, two different decomposition analyses are performed and results are compared. The refined Laspeyres index method is adopted, and for each analysis, three main factors are considered. The empirical findings demonstrate that the income effect and population effect increased Turkiye’s total energy use, whereas the energy intensity effect decreased it. The first decomposition analysis for the industrial energy use reveals partly contrasting results with the previously published articles. For the industry sector, the second analysis show that productivity and employment increased Turkiye’s sectoral energy use; however, the sector’s energy intensity reduced it. Turkiye achieved some success in terms of reducing energy intensity at the sectoral and aggregate levels; however, as the findings of the present study demonstrate, further efforts are needed to lessen the country’s energy dependence and also to achieve future environmental sustainability targets. Trends relating to the determining factors in total and sectoral energy use are also compared in this paper, and some policy implications are presented.
Unraveling the mysteries of wormhole formation in Rastall–Rainbow gravity: a comprehensive study using the embedding approach
Authors: Errehymy Abdelghani , Banerjee Ayan , Donmez Orhan , Daoud Mohammed , Nisar Kottakkaran Sooppy , Abdel-Aty Abdel-Haleem 
Published: June 2024

AbstractThe present work looks for the possible existence of static and spherically symmetric wormhole geometries in Rastall–Rainbow gravity. Since, the Rastall–Rainbow gravity model has been constructed with the combination of Rastall theory and the gravity’s rainbow formalism. Taking advantage of the Karmarkar condition for embedding class one metrics, we solve the modified field equations analytically that describe wormholes for specific choice of redshift function. For specific parameter ranges, the solution represents a traversable wormhole that exhibits the violation of null energy condition and consequently the weak energy condition also. Furthermore, we focus on the wormhole stability via adiabatic sound velocity analysis. This model establishes a strong connection between two model parameters, namely, the Rastall parameters and the Rainbow functions, and how it affects the wormhole solution.
An autoethnography of internationalisation: ethical dilemmas in Japanese academe
Authors: Dalgliesh Bregham 
Published: June 2024

AbstractVia an autoethnography of internationalisation, the article highlights the ethical dilemmas transnational scholars face when universities fail to denationalise their organisational culture. Section one explains the pertinence and pitfalls of autoethnography — writing oneself into existence over against a context experienced as domination — for grasping the ethical quandaries of transnational scholars in a Japanese national university (JNU). As section two shows, the persistence of ethno-national working practices in JNUs precludes both the equal treatment of transnational scholars and the recognition of their difference. Specifically, the discussion documents two mechanisms of marginalisation at the JNU in question, Tōdai (University of Tokyo): section three links the rejection of ethno-national diversity to absolutisation, viz. the generalisation of prejudice by gatekeepers in order to stigmatise transnational scholars as unfit for organisational life; and section four contends gatekeepers defend their territorialised academic culture through normalisation, which is underpinned by academic inbreeding that produces a hermitic community of sameness blind to its ethno-national prejudices. The article concludes with the ethical gymnastics of transnational scholars situated in universities that solicit their multiplicity without renovating their ethno-national culture. It also reflects upon the limited leverage of autoethnography beyond the Anglosphere, notably in a JNU organisational environment that does not recognise the strop of agency with structure. Finally, the article suggests Japan would be better off promoting a cultural form of internationalisation rather than following a commercial iteration with neo-colonial costs.
Against Common Sense: On the Utopian Aspect of Concepts
Authors: Pyyhtinen Olli 
Published: June 2024

AbstractBy supplementing the work of Schutz, the article critically contests the methodological requirement, widely accepted within phenomenological sociology, that social scientific constructs be consistent with the constructs of common-sense experience of social reality. First, the article proposes that insofar as our everyday ways of speaking and thinking perceive the world as consisting of static and self-consistent entities, adhering to the methodological requirement makes research vulnerable to substantialist assumptions. To be able to account for how things change and involve other entities in their make-up therefore ultimately requires going against common sense along the lines of processual-relational thinking. Second, the article suggests that adhering too strictly to the methodological requirement easily renders social scientific concepts reactive and representational, trapped within the present and the actual. Against this, the article argues for a view of concepts as active and creative, stressing their utopian aspects. Social scientific thinking that gravitates towards creation emphasises potentiality and the future instead of perpetuating the actual and the present: it engages with present practices, institutions, and structures for the benefit of the future. Instead of merely describing or representing the social world as it is, its concepts present a challenge to what is, and thereby open up new ways of thinking, acting, and being and potentially “give a new event to things”.