bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH MEDIASI KINERJA KEUANGAN ANTARA PEMANFAATAN ASET DAN PROFIT MARGIN TERHADAP NILAI PASAR PERUSAHAAN DI INDONESIA
Authors: Jamaludin Jamaludin , Leon Farah Margaretha , Chandra Kristian 
Published: July 2024

Penelitian ini bertujuan untuk menganalisis pengaruh mediasi Kinerja Keuangan antara Pemanfaatan Aset dan Marjin Keuntungan dengan Nilai Pasar Perusahaan. Data yang digunakan dalam penelitian ini merupakan data sekunder yang bersumber dari laporan tahunan perusahaan berbagai sektor yang tercatat di Bursa Efek Indonesia dan pernah masuk ke dalam daftar index lq-45 selama periode 2018 - 2022. Sampel penelitian dipilih menggunakan metode purposive sampling sehingga diperoleh 49 perusahaan yang masuk kriteria untuk menjadi sampel. Analisis data yang digunakan untuk uji hipotesis yaitu analisis regresi berganda dengan menggunakan program Eviews.
Hasil penelitian menunjukkan bahwa variabel Pemanfaatan aset dan variabel marjin keuntungan sebagai variabel independen memiliki pengaruh positif dan signifikan terhadap Nilai Pasar Perusahaan sebagai variabel dependennya. Selain itu, variabel Kinerja Keuangan terbukti dapat memediasi dengan arah hubungan positif antara pemanfaatan aset dan nilai pasar perusahaan. Hasil penelitian ini memberikan pandangan bahwa dengan pemanfaatan aset perusahaan yang efektif dan efisien akan meningkatkan kinerja keuangan perusahaan yang pada akhirnya dapat meningkatkan pula nilai perusahaan di pasar. Selain itu, konsistensi pencapaian marjin keuntungan dalam trend positif, secara nyata juga dapat meningkatkan nilai perusahaan, yang dibuktikan dengan peningkatan keuntungan dari pendapatan perusahaan. Dengan meningkatnya nilai perusahaan, tentu akan menarik bagi investor untuk melakukan penanaman modalnya di perusahaan.
Los estereotipos de género y cómo afectan en la participación de las mujeres en la educación técnica
Authors: Segarra Arias Alvaro Luis , Tanguila López Geovanna Jessica , Martínez Pérez Odette , Paredes Cabezas Maribel del Rocío 
Published: July 2024

Introducción: En el avance social y los esfuerzos por promover la igualdad de género, persisten desigualdades, especialmente en áreas técnicas, donde la participación femenina es escasa o nula. Objetivo: Fomentar la igualdad donde todas las personas, a través de la inclusión para contribuir a la construcción de una sociedad más equitativa, innovadora y justa. Metodología: Métodos de análisis estadístico, QQPlot y T-Student. Resultados: Indican que existen un mayor número de hombres en los bachilleratos técnicos. Conclusión: Se debe implementar estrategias para garantizar la igualdad de competencias en estas figuras profesionales. Área de estudio general: Educación. Área de estudio específica: Equidad de género.
Plan de vinculación del bachillerato técnico con la agroindustria, para fortalecer la figura profesional de producción agropecuaria
Authors: Ayora León David Gustavo , Sánchez Jinez Jean Carlos , García Hevia Segress , Raigosa Lara Alejandro 
Published: July 2024

Introducción: El presente trabajo investigativo analiza la utilización de infraestructura agroindustrial educativa como medios didácticos para el proceso de enseñanza aprendizaje en el Bachillerato Técnico y plantea alternativas de vinculación entre estos espacios productivos y el área agropecuaria. El Colegio de Bachillerato “Primero de Mayo” de la provincia de Zamora Chinchipe, cantón Yantzaza ha sido considerado como referente para este estudio. Objetivo: desarrollar un plan que permita vincular la infraestructura agroindustrial que poseen las instituciones educativas con la Figura Profesional de Producción Agropecuaria. Metodología: Se ha utilizado un tipo de investigación no experimental, adicionalmente se ha empleado las encuestas como técnica de recolección de datos a través de un cuestionario mixto, aplicado a docentes, estudiante y directivos institucionales. Resultados: Entre los resultados se encuentran la vinculación indirecta entre las plantas de lácteos y cárnicos y la Figura Profesional de Producción Agropecuaria, así también la necesidad de vincular las actividades prácticas a un módulo formativo, adicionalmente se considera fundamental la realización de la Formación en Centros de Trabajo en los espacios agroindustriales de la institución. Conclusiones: Se debe aprovechar los recursos institucionales como las plantas de lácteos y cárnicos para potenciar el bachillerato técnico y mejorar las habilidades prácticas del estudiantado. Área de estudio general: Educación. Área de estudio específica: Bachillerato Técnico. Tipo de estudio: Artículos originales.
Estrategia didáctica basada en la tecnología educativa para mejorar el aprendizaje de matemática en los estudiantes del primer año de BGU de la Unidad Educativa Humberto Fierro
Authors: Obando Guamán Jacinto Joaquín , Villalva Heredia Carlos Iván , Guzmán Hernández Ramón 
Published: July 2024

Introducción. El empleo de las TIC es un mecanismo que permite desarrollar estrategias didácticas utilizando las tecnologías educativas apoyadas en la teoría del diseño instruccional para lo cual es necesario una actualización de contenidos y las formas de enseñar los contenidos educativos los cuales deben estar acordes con el currículo establecido en el diseño curricular del área de matemáticas. La educación requiere del uso de estrategias didácticas adecuadas y personalizadas a fin de alcanzar una educación de calidad. La Tecnología Educativa (TE) es un sistema multidisciplinario que combina las TICs y la pedagogía para perfeccionar el proceso de enseñanza – aprendizaje y se emplea este sistema para fortalecer el aprendizaje experiencial. Objetivo. Proponer una estrategia didáctica basada en tecnología educativa para mejorar el aprendizaje en el área de Matemática en los estudiantes del primer año de BGU de la Unidad Educativa Humberto Fierro. Metodología. Para desarrollar la investigación se empleó el enfoque cuantitativo, el tipo de investigación es descriptiva y documental, el diseño de la investigación según el tiempo es No Experimental de Corte Transversal. Se realizó un análisis de los datos utilizando técnicas de la estadística descriptiva para identificar patrones, tendencias o relaciones entre las variables de interés. La población de estudio fue de: 460 estudiantes; la muestra fue de 50 estudiantes del primer año de BGU. Resultados. La mayoría de los estudiantes percibe que los recursos tecnológicos facilitan la resolución de problemas matemático, La necesidad de utilizar entornos virtuales fue respaldada por el 66% con "La mayoría de veces sí" y el 34% con "Siempre". Conclusión. Las estrategias didácticas y el uso de tecnología educativa fueron vistas de manera favorable. lo que sugiere una adaptación exitosa de las estrategias a las necesidades individuales de los estudiantes. Área de estudio general: Educación. Área de estudio específica: Pedagogía. Tipo de estudio: Artículos originales
Transcriptomic analysis of primary nasal epithelial cells reveals altered interferon signalling in preterm birth survivors at one year of age
Authors: Evans Denby J. , Hillas Jessica K. , Iosifidis Thomas , Simpson Shannon J. , Kicic Anthony , Agudelo-Romero Patricia 
Published: July 2024

Introduction: Many survivors of preterm birth (&lt;37 weeks gestation) have lifelong respiratory deficits, the drivers of which remain unknown. Influencers of pathophysiological outcomes are often detectable at the gene level and pinpointing these differences can help guide targeted research and interventions. This study provides the first transcriptomic analysis of primary nasal airway epithelial cells in survivors of preterm birth at approximately 1 year of age.Methods: Nasal airway epithelial brushings were collected, and primary cell cultures established from term (&gt;37 weeks gestation) and very preterm participants (≤32 weeks gestation). Ex vivo RNA was collected from brushings with sufficient cell numbers and in vitro RNA was extracted from cultured cells, with bulk RNA sequencing performed on both the sample types. Differential gene expression was assessed using the limma-trend pipeline and pathway enrichment identified using Reactome and GO analysis. To corroborate gene expression data, cytokine concentrations were measured in cell culture supernatant.Results: Transcriptomic analysis to compare term and preterm cells revealed 2,321 genes differentially expressed in ex vivo samples and 865 genes differentially expressed in cultured basal cell samples. Over one third of differentially expressed genes were related to host immunity, with interferon signalling pathways dominating the pathway enrichment analysis and IRF1 identified as a hub gene. Corroboration of disrupted interferon release showed that concentrations of IFN-α2 were below measurable limits in term samples but elevated in preterm samples [19.4 (76.7) pg/ml/µg protein, p = 0.03]. IFN-γ production was significantly higher in preterm samples [3.3 (1.5) vs. 9.4 (17.7) pg/ml/µg protein; p = 0.01] as was IFN-β [7.8 (2.5) vs. 13.6 (19.5) pg/ml/µg protein, p = 0.01].Conclusion: Host immunity may be compromised in the preterm nasal airway epithelium in early life. Altered immune responses may lead to cycles of repeated infections, causing persistent inflammation and tissue damage which can have significant impacts on long-term respiratory function.
A network meta-analysis: evaluating the efficacy and safety of concurrent proton pump inhibitors and clopidogrel therapy in post-PCI patients
Authors: Ai Ming-Ying , Chen Yan-Zuo , Kuo Chien-Liang , Chang Wei-Lun 
Published: July 2024

IntroductionThe objective of this research was to evaluate the risk of major adverse cardiovascular events (MACEs) associated with the use of various proton pump inhibitors (PPIs) in combination with clopidogrel in patients who underwent percutaneous coronary intervention (PCI).MethodsTo accomplish this, we analyzed data from randomized controlled trials and retrospective cohort studies sourced from key electronic databases. These studies specifically examined the effects of different PPIs, such as lansoprazole, esomeprazole, omeprazole, rabeprazole, and pantoprazole, when used in conjunction with clopidogrel on MACEs. The primary focus was on the differential impact of these PPIs, while the secondary focus was on the comparison of gastrointestinal (GI) bleeding events in groups receiving different PPIs with clopidogrel vs. a placebo group. This study's protocol was officially registered with INPLASY (INPLASY2024-2-0009).ResultsWe conducted a network meta-analysis involving 16 studies with a total of 145,999 patients. Our findings indicated that rabeprazole when combined with clopidogrel, had the lowest increase in MACE risk (effect size, 1.05, 95% CI: 0.66–1.66), while lansoprazole was associated with the highest risk increase (effect size, 1.48, 95% CI: 1.22–1.80). Esomeprazole (effect size, 1.28, 95% CI: 1.09–1.51), omeprazole (effect size, 1.23, 95% CI: 1.07–1.43), and pantoprazole (effect size, 1.38, 95% CI: 1.18–1.60) also significantly increased MACE risk. For the secondary outcome, esomeprazole (effect size, 0.30, 95% CI: 0.09–0.94), omeprazole (effect size, 0.34, 95% CI: 0.14–0.81), and pantoprazole (effect size, 0.33, 95% CI: 0.13–0.84) demonstrated an increased potential for GI bleeding prevention.ConclusionsIn conclusion, the combination of lansoprazole and clopidogrel was found to significantly elevate the risk of MACEs without offering GI protection in post-PCI patients. This study is the first network meta-analysis to identify the most effective regimen for the concurrent use of clopidogrel with individual PPIs.Systematic Review Registrationhttps://inplasy.com/inplasy-2024-2-0009/, identifier (INPLASY2024-2-0009).
Case report: First Chinese patient with family partial lipodystrophy type 6 due to novel compound heterozygous mutations in the LIPE gene
Authors: Zhou Yimeng , Zhang Lin , Ding Yang , Zhai Yongzhen 
Published: July 2024

BackgroundFamily partial lipodystrophy (FPLD) is a rare autosomal dominant disease characterized by disorders of variable body fat loss associated with metabolic complications. FPLD6 has only been reported in a limited number of cases. Here, we reported a Chinese FPLD6 patient with compound heterozygous mutations in the lipase E, hormone-sensitive type (LIPE) gene.Case presentationA 20-year-old female patient presented with hypertriglyceridemia, diabetes mellitus, hepatomegaly, and hepatic steatosis. Subcutaneous fat was significantly diminished in her face, abdomen, and limbs. The patient was assessed by detailed clinical and biochemical examinations. A liver biopsy showed severe lipodystrophy. In addition, there were retinal changes, peripheral nerve damage, and renal tubular injury. Sequencing was performed on extracted DNA. Genetic analysis revealed that the patient had compound heterozygous mutations in the LIPE gene: c.2497_250ldel (p.Glu833LysfsTer22) and c.2705del (p.Ser902ThrfsTer27) heterozygous mutations. Verification revealed that this mutation was inherited from her father and mother, respectively, and that they formed newly discovered compound heterozygous mutations occurring in the LIPE gene, causing FPLD6.ConclusionWe reported the first case of FPLD6 in China. Gene analysis demonstrated compound heterozygous mutations in LIPE in this patient. Our case emphasizes the importance of genetic testing in young patients with severe metabolic syndromes.
Genetically predicted allergic rhinitis causally increases the risk of erectile dysfunction
Authors: Li Peng , Meng Zhaotun , Lin Liqiang , Chen Zhipeng , Lv Huaiqing 
Published: July 2024

ObjectiveEvidence shows that allergic rhinitis (AR) may increase the risk of erectile dysfunction (ED). This study aims to investigate whether there is a causal relationship between AAR and ED by Mendelian randomization (MR) analysis.MethodsWe performed a two-sample MR analysis using genome-wide association studies (GWAS) summary data. Single nucleotide polymorphisms (SNPs) associated with AR and ED were obtained from the GWAS database. The MR analysis primarily employed the inverse variance weighted (IVW), MR Egger, and weighted median (WM) methods. We assessed pleiotropy using the MR-PRESSO global test and MR-Egger regression. Cochran’s Q test was used to evaluate heterogeneity, and a leave-one-out analysis was performed to verify the robustness and reliability of the results.ResultsThe IVW analysis demonstrated a positive association between genetic susceptibility to AR and an elevated relative risk of ED (IVW OR = 1.40, p = 0.01, 95% CI 1.08–1.80). The results obtained from MR-Egger regression and WM methods exhibited a consistent trend with the results of the IVW method. Sensitivity analyses showed no evidence of heterogeneity nor horizontal pleiotropy. The leave-one-out analysis showed that the findings remained robust and were unaffected by any instrumental variables.ConclusionThis study presents genetic evidence that indicates a causal association between AR and ED.
Avatrombopag as alternative therapy for severe aplastic anemia patients who are intolerant or unresponsive to eltrombopag
Authors: Zhang Ting , Yu Qingling , Chen Xiaoyu , Yang Hui , Gong Yuemin , Zhang Yawen , Liu Xiaoqing , Yang Zhinan , Fang Yu , Yan Xue , Zhou Xuan , Shi Jinning , He Guangsheng 
Published: July 2024

IntroductionEltrombopag (EPAG), a thrombopoietin receptor agonist, was approved for the treatment of severe aplastic anemia (SAA) combined with immunosuppressive therapy (IST). However, EPAG contains a typical biphenyl structure, which causes liver function damage.MethodsTwenty patients with SAA who were intolerant or refractory to EPAG were enrolled in a multicenter prospective registry of the Chinese Eastern Collaboration Group of Anemia (ChiCTR2100045895) from October 2020 to June 2023.ResultsEight patients who were ineffective to EPAG, six with kidney impairment, and nine with abnormal liver function (two with concomitant liver and kidney impairment) were converted to avatrombopag (AVA) therapy with the median duration of AVA treatment was 6 (3-24) months. 17 cases (85%) achieved trilineage hematological response (HR): complete remission (CR) in 3 cases (15%), good partial remission (GPR) in 4 cases (20%), partial remission (PR) in 10 cases (50%), and no response (NR) in 3 cases (15%). The median time to response was 1.7 (0.5-6.9) months, with 16 cases (94%) achieving response within six months and 17 cases (100%) within 12 months. 9 cases (50%) achieved transfusion independence. AVA converted treatment was associated with higher neutrophil counts (0.8×109/L vs 2.2×109/L, p=0.0003), platelet counts (11×109/L vs 39×109/L, p=0.0008), hemoglobin count (59g/L vs 98g/L, p=0.0002), red cell count (1.06×1012/L vs 2.97×1012/L, p=0.001), and absolute reticulocyte count (31.99 ×109/L vs 67.05×109/L p=0.0004) were all significantly elevated compared with the pre-treatment level. After the conversion to AVA therapy, liver and kidney function indexes were maintained within the normal range, no AVA related grade 2 or higher adverse events occurred, and no thrombotic events occurred.ConclusionThe conversion to AVA was an optimal choice for patients with SAA who were EPAG intolerant or refractory.Clinical trial registrationhttp://www.chictr.org.cn/showproj.html?proj=125480, identifier ChiCTR2100045895.
The optimal dose of dexmedetomidine as a 0.59% ropivacaine adjuvant for epidural anesthesia in great saphenous varicose vein surgery, based on hemodynamics and anesthesia efficacy: a randomized, controlled, double-blind clinical trial
Authors: Zeng Sisi , Li Xuechao , Xu Hongchun , Ye Qin , Li Zhaogang , Wang Fangjun 
Published: July 2024

ObjectiveThis study aimed to explore the optimal dose of dexmedetomidine as a 0.59% ropivacaine adjuvant for epidural anesthesia on perioperative hemodynamics and anesthesia efficacy in patients undergoing great saphenous varicose vein surgery.MethodsA total of 90 patients were randomly divided into three groups: 0.25 μg/kg dexmedetomidine combined with 0.59% ropivacaine epidural infusion group (ED1 group), 0.5 μg/kg dexmedetomidine combined with 0.59% ropivacaine epidural infusion group (ED2 group), and 0.75 μg/kg dexmedetomidine combined with 0.59% ropivacaine epidural infusion group (ED3 group). Hemodynamics, anesthesia efficiency, and adverse reactions were recorded.Main resultsCompared with the ED1 group, the ED2 group had lower systolic blood pressure at T1-3 (T1, 95%CIs, 6.52–21.93, p &lt; 0.001; T2, 95%CIs, 2.88–18.21, p = 0.004; T3, 95%CIs, 0.49–18.17, p = 0.035), and the diastolic blood pressure at T1-2 was decreased (T1, 95%CIs, 4.55–14.36, p &lt; 0.001; T2, 95%CIs, 0.37–12.17, p = 0.033). Compared with the ED2 group, the ED3 group had higher systolic blood pressure at T1-2 (T1, 95%CIs, 5.90–21.46, p &lt; 0.001; T2, 95%CIs, 2.07–17.55, p = 0.008) and higher diastolic blood pressure at T1-3 (T1, 95%CIs, 2.91–12.81, p = 0.001; T2, 95%CIs, 1.32–13.23, p = 0.011; T3, 95%CIs, 0.14–11.52, p = 0.043). Compared with the ED2 group, the heart rate was significantly decreased at T1-4 in the ED3 group (T1, 95%CIs, 2.25–15.72, p = 0.005; T2, 95%CIs, 2.35–13.82, p = 0.003; T3, 95%CIs, 0.50–9.79, p = 0.025; T4, 95%CIs, 1.46–10.36, p = 0.005). The myocardial oxygen consumption in all three groups was significantly decreased at each time point compared to T0 (p &lt; 0.05 or &lt; 0.001), and no significant between-group differences were detected (P&gt;0.05). Compared with the ED1 group, the anesthesia efficiency of ED2 and ED3 groups was markedly enhanced, but the risk of bradycardia in ED2 and ED3 groups was dramatically increased (6 of 28 [21.4%] vs. 14 of 30 [46.7%] and 14 of 27 [51.9%], p = 0.023), one patient in the ED3 group experienced difficulty urinating, and remaining adverse reactions were mild in all three groups.ConclusionA measure of 0.5 μg/kg dexmedetomidine is the optimal dose as a 0.59% ropivacaine adjuvant for epidural anesthesia in patients undergoing great saphenous varicose vein surgery.Clinical trial registrationhttp://www.chictr.org.cn/, registration number: ChiCTR2200060619.
Modeling riboflavin transporter deficiency type 2: from iPSC-derived motoneurons to iPSC-derived astrocytes
Authors: Magliocca Valentina , Lanciotti Angela , Ambrosini Elena , Travaglini Lorena , D’Ezio Veronica , D’Oria Valentina , Petrini Stefania , Catteruccia Michela , Massey Keith , Tartaglia Marco , Bertini Enrico , Persichini Tiziana , Compagnucci Claudia 
Published: July 2024

IntroductionRiboflavin transporter deficiency type 2 (RTD2) is a rare neurodegenerative autosomal recessive disease caused by mutations in the SLC52A2 gene encoding the riboflavin transporters, RFVT2. Riboflavin (Rf) is the precursor of FAD (flavin adenine dinucleotide) and FMN (flavin mononucleotide), which are involved in different redox reactions, including the energetic metabolism processes occurring in mitochondria. To date, human induced pluripotent stem cells (iPSCs) have given the opportunity to characterize RTD2 motoneurons, which reflect the most affected cell type. Previous works have demonstrated mitochondrial and peroxisomal altered energy metabolism as well as cytoskeletal derangement in RTD2 iPSCs and iPSC-derived motoneurons. So far, no attention has been dedicated to astrocytes.Results and discussionHere, we demonstrate that in vitro differentiation of astrocytes, which guarantee trophic and metabolic support to neurons, from RTD2 iPSCs is not compromised. These cells do not exhibit evident morphological differences nor significant changes in the survival rate when compared to astrocytes derived from iPSCs of healthy individuals. These findings indicate that differently from what had previously been documented for neurons, RTD2 does not compromise the morpho-functional features of astrocytes.
The network is more important than the node: stereo-EEG evidence of neurocognitive networks in epilepsy
Authors: Murray Nicholas W. G. , Kneebone Anthony C. , Graham Petra L. , Wong Chong H. , Savage Greg , Gillinder Lisa , Fong Michael W. K. 
Published: July 2024

IntroductionNeuropsychological assessment forms an integral part of the presurgical evaluation for patients with medically refractory focal epilepsy. Our understanding of cognitive impairment in epilepsy is based on seminal lesional studies that have demonstrated important structure-function relationships within the brain. However, a growing body of literature demonstrating heterogeneity in the cognitive profiles of patients with focal epilepsy (e.g., temporal lobe epilepsy; TLE) has led researchers to speculate that cognition may be impacted by regions outside the seizure onset zone, such as those involved in the interictal or “irritative” network.MethodsNeuropsychological data from 48 patients who underwent stereoelectroencephalography (SEEG) monitoring between 2012 and 2023 were reviewed. Patients were categorized based on the site of seizure onset, as well as their irritative network, to determine the impact of wider network activity on cognition. Neuropsychological data were compared with normative standards (i.e., z = 0), and between groups.ResultsThere were very few distinguishing cognitive features between patients when categorized based purely on the seizure onset zone (i.e., frontal lobe vs. temporal lobe epilepsy). In contrast, patients with localized irritative networks (i.e., frontal or temporal interictal epileptiform discharges [IEDs]) demonstrated more circumscribed profiles of impairment compared with those demonstrating wider irritative networks (i.e., frontotemporal IEDs). Furthermore, the directionality of propagation within the irritative network was found to influence the manifestations of cognitive impairment.DiscussionThe findings suggest that neuropsychological assessment is sensitive to network activity beyond the site of seizure onset. As such, an overly focal interpretation may not accurately reflect the distribution of the underlying pathology. This has important implications for presurgical work-up in epilepsy, as well as subsequent surgical outcomes.