bluuebunny/crossref_metadata_2025_split huggingface dataset:
An examination of the relationship between risk perceptions, cultural-religious beliefs and coping during COVID-19 pandemic control in South Asian countries: a systematic review
Authors: Memon Rakhshi , Khaliq Ayesha , Ranieri Veronica , Asif Muqaddas , Bhatti Mujeeb Masood , Khan Bilal Ahmad , Chaudhry Nasim , Chauhdry Imran B. , Husain Nusrat , Edwards Sarah J. L. 
Published: August 2024

Abstract
Background
Covid 19 was declared as a public health emergency by the World Health Organisation (WHO) due to its rapid spread and catastrophic effects on health. It affected around 119 M people with mortality rate of 0.27% worldwide, including South-Asians. This review aims to understand the risk perceptions, cultural religious beliefs and the coping mechanisms of South Asians during the Covid 19 pandemic.

Methods
We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following search engines were used: Medline, Cochrane Library, PsycINFO, CINAHL, and Web of Science. Included studies investigated perceptions and opinions of individuals on knowledge, risk and protective factors, native faith based practices, and attitudes towards the COVID-19 pandemic.

Results
The database search produced 282 articles to screen. The final narrative synthesis included five studies comprising of 13,476 participants from Pakistan, India, Nepal, and Bangladesh. Ten studies, comprising 7,893 participants, were eligible and included for meta-analysis. The overall pooled prevalence with maximum heterogeneity for correct knowledge of symptoms, hand washing or use of sanitizers, face masking use of herbal or traditional remedies and physical distancing or avoidance of contact was reported through meta-analysis.

Conclusion
The review brings forth a useful comparison of individual and cultural differences in KAP, risk perceptions and coping strategies. This review highlights the need for and importance of tailored information dissemination, culturally sensitive risk communication, targeted educational interventions, community engagement and empowerment, policy, and infrastructure improvements, as well as continued research and data collection. By addressing these implications, efforts to mitigate the impact of COVID-19 can be more effective and equitable across diverse populations.

Prospero registration
CRD42021246475.
The pioneer Cluster mission: preparation of its legacy phase near re-entry
Authors: Masson Arnaud , Escoubet C. Philippe , Taylor Matthew G. G. T. , Sieg Detlef , Sanvido Silvia , Abascal Palacios Beatriz , Lemmens Stijn , Sousa Bruno 
Published: August 2024

AbstractThe Cluster mission will always be the first ever multi-spacecraft mission mapping the Earth magnetosphere in three dimensions. Launched in 2000 and originally planned to operate for two years, it has been orbiting Earth for more than two solar cycles. Over the course of its lifetime, its data have enabled the scientific community to conduct pioneer science. Recent scientific highlights will be presented first, followed by the latest scientific objectives that have guided the Cluster mission operations from 2021 until 2024. Early September 2024, one spacecraft of this veteran constellation will re-enter in a controlled manner the Earth’s atmosphere, followed by its companions in 2025 and 2026. As we will see, this will be a unique opportunity to improve the ESA space debris re-entry models. Lastly, preparation of its legacy phase will be presented.
Graphical Abstract
Orthotopic heart transplantation in patient with situs inversus and pectus excavatum: a case report
Authors: Wakasa Satoru , Ooka Tomonori , Sato Takuma , Shingu Yasushige , Kato Nobuyasu , Nagai Toshiyuki , Anzai Toshihisa , Ono Minoru , Matsui Yoshiro 
Published: August 2024

Abstract
Background
Heart transplantation in patients with situs inversus is challenging, especially in terms of reconstruction of the systemic venous return. Several rerouting techniques have been presented but are associated with vulnerability to external compression, which might cause hemodynamic instability, especially in the presence of chest deformity. In this study, we report a rare case of successful heart transplantation in the presence of situs inversus and pectus excavatum.

Case presentation
A 55-year-old man, with a history of surgeries for corrected transposition of the great arteries with ventricular septal defect, was registered for heart transplantation owing to progression of heart failure. Subsequently, he had undergone a left ventricular assist device implantation; 14 years after registration, he underwent transplantation of the heart with normal anatomy. The inferior vena cava was reconstructed by anastomosing the left atria with a counterclockwise rotation of the donor heart and by lengthening the recipient inferior vena cava with a conduit made of the residual right atrial tissue. The superior vena cava was reconstructed using a donor innominate vein harvested with sufficient length. After successful weaning from cardiopulmonary bypass, the chest could not be closed because the heart was compressed owing to chest deformity, resulting in hemodynamic instability. Therefore, to exclude the left lung, a left pericardial screen was created using a bovine pericardium, allowing the chest to be closed with acceptable hemodynamics. The patient suffered postoperatively from a higher venous pressure, suggesting an obstruction of venous return early after surgery. The obstruction gradually resolved, and the patient was transferred for rehabilitation.

Conclusions
Heart transplantation in the presence of situs inversus is challenging; moreover, the presence of pectus excavatum further complicates the procedure. The paradoxically larger left lung and chest deformity compressed and impaired reconstructed systemic venous return. Although intrathoracic exclusion of the left lung was effective, an intraoperative or early postoperative thoracoplasty for pectus excavatum was also a viable option. Patient-specific management is mandatory, depending on the anatomy.
Assessment of interleukin-6 and cathepsin-B gene expression in breast cancer women
Authors: Ibrahim Basma A. , Nagdy Eman S. , Nour Eldin Essam , Khalil Alaa M. I. , El-Taher Ahmed K. 
Published: August 2024

Abstract
Background
Breast cancer (BC) is the most prevalent cancer and the leading cause of cancer-related deaths in women globally. Cysteine protease cathepsin-B has been implicated in various human malignancies and is involved in malignancy progression and metastasis. This study aimed to evaluate the circulating levels of cathepsin-B, interleukin-6 (IL-6), and CA15-3, a cancer antigen, as biomarkers for tumors in women with both localized and metastatic BC. The study employed a case-control design, enrolling 108 participants categorized into three groups: healthy individuals, those with localized BC, and those with metastatic BC. The relative mRNA expression of cathepsin-B in blood samples was assessed using qRT-PCR. Additionally, serum levels of IL-6 and CA15-3 were quantified using ELISA.

Results
The relative mRNA expression of cathepsin-B, IL-6 levels, and CA15-3 levels were significantly higher in metastatic BC cases than in localized BC cases and the control group (p-value < 0.001). A statistically significant positive correlation was also found between cathepsin-B and both IL-6 and CA15-3 (r = 0.905, r  = 0.667, and p < 0.001), respectively.

Conclusions
The findings indicate a strong correlation between the interaction of the proteolytic enzyme cathepsin-B and IL-6 with the unfavorable prognosis of BC. This relationship may serve as a potential indicator and a promising target for therapy in BC treatment.
Could ultrasound alone substitute MR imaging in evaluation of Crohn’s disease complications?
Authors: El-Assaly Hany , Mohamed Asmaa Abdel Baky , Mustafa Hesham Adel Abdel Fattah 
Published: August 2024

Abstract
Background
Crohn’s disease is a chronic disease that causes remitting and relapsing inflammatory episodes in the transmural part of the gastrointestinal system. It usually affects young people. The study sought to establish whether ultrasound can visualize important/useful diagnostic features and complications of the disease in the same way that MR enterography (MRE) can. The study is a prospective cohort of 133 patients of various disease stages (active and in remission) who had previously been seen by a gastroenterologist. All patients underwent abdominal and pelvic ultrasound examinations, with each of the five intestine segments checked independently for thickening and active inflammation. Complications of fistulas, abscesses, and stenosis were evaluated. Findings at MRE together with ileocolonoscopic results were deemed the standard reference.

Results
Ultrasound showed wall stenosis ranging from 5 to 12 mm, with a mean ± SD of 7.73 ± 2.30. A single loop was present in 69.2% of cases. The ileum was the most heavily involved loop portion (66.7%). In 72.9% of patients, stenosis and dilatation were present, whereas 69.7% showed active inflammation. Complications such as fistulas and abscess formation (21.2%) were identified. Ultrasound was found to be an effective tool for detecting stenosis and dilatation in the examined patients, with sensitivity of 84% and 87%, and specificity of 91% and 97%, respectively. A high accuracy of 90.9% was demonstrated for abscess formation.

Conclusions
Ultrasound is a noninvasive method that is comparable to MRI for detecting damaged bowel segments and transmural complications such as bowel strictures, fistulas, and abscesses in Crohn’s disease patients. However, MR imaging is more comprehensive in providing detailed information about the disease's extent and activity.
Rapid growth of calcified amorphous tumor with mitral annulus calcification: a case report
Authors: Ozoe Satoki , Koyama Yutaka , Inagaki Masahiro , Tomita Shinji 
Published: August 2024

Abstract
Background
Calcified amorphous tumor (CAT) of the heart is a rare, non-neoplastic cardiac mass with mitral valves and annuli being the most common sites. The presence of mitral annular calcification (MAC) is associated with an increased risk of stroke or other systemic embolisms. Here, we report a case of CAT showing rapid growth with MAC and investigate the link between the two.

Case presentation
A 71-year-old man presented at our hospital with dyspnea and had been undergoing hemodialysis for 26 years for chronic glomerulonephritis. Transthoracic echocardiography (TTE) revealed moderate mitral stenosis with bulky MAC. Two months later, the patient developed progressive dyspnea, and follow-up TTE revealed a highly mobile mass (8 × 5 mm) attached to the left ventricular (LV) side of the posterior MAC. He underwent surgery because of congestive heart failure and a high risk of embolization. Surgical inspection revealed that the tumor was attached beneath the P3 segment of the mitral valve on the LV side and was removed. When removing the MAC, toothpaste-like contents drained from the encapsulated mass inside the MAC at the P3 segment, where the tumor was located. After reconstructing the posterior mitral annulus defect with a bovine pericardial patch, mitral valve replacement with a mechanical prosthesis, a maze procedure, and left appendage closure were performed. Histopathological examination revealed that the excised tumor contained fibrin and calcium deposits. The mass was diagnosed as a CAT.

Conclusions
CAT may be one of the causes of stroke induced by MAC. Routine follow-up echocardiography should be recommended for patients with MAC, especially those undergoing hemodialysis.
Euglycemic Ketoacidosis From Semaglutide in a Patient Without Diabetes
Authors: Sood Nikhil , Bansal Ojas , Garg Rohini , Hoskote Abhinav 
Published: August 2024

Abstract
Euglycemic ketoacidosis is a medical emergency characterized by euglycemia, metabolic acidosis, and ketonemia. It is a well-recognized adverse event in patients with diabetes taking sodium-glucose cotransporter-2 inhibitors. However, little has been reported about euglycemic ketoacidosis using glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide. We present a case of euglycemic ketoacidosis in a young female without diabetes who was taking semaglutide for weight loss for the last 7 months. She was treated with bicarbonate-containing dextrose infusion, which improved the ketoacidosis rapidly. The incidence of euglycemic ketoacidosis will likely increase with the increasing use of GLP-1 inhibitors, and recognizing the signs and symptoms of this life-threatening condition is essential to treat it effectively. Our literature search identified 1 reported case of euglycemic ketoacidosis in a patient without diabetes associated with tirzepatide but none with semaglutide.
Beneficial effects of alternative methods, with an emphasis on yoga, for patients affected by pain associated with endometriosis
Authors: Kutyła Katarzyna , Marszałek Anna , Choiński Maciej , Wasiewicz-Ciach Paulina , Marzec Marcelina Teresa , Kuczyński Piotr , Wydra-Rojek Aleksandra , Łakoma Aleksandra , Marzec Weronika Zofia , Mokot Wojciech Jan 
Published: August 2024

Aim of the study
The aim of this systematic review is to compare studies published since 2017 to evaluate whether yoga and other alternative methods should be recommended to patients with endometriosis and associated pain. As alternative methods, particularly yoga, have gained popularity in recent years, it is crucial for healthcare professionals to ensure that these approaches are scientifically valid. This systematic review examines the effects of practicing different types of yoga and possible advantages of other alternative methods that could be potentially beneficial on pain management for patients suffering form endometriosis.
Methods
This review synthesizes findings from twenty studies, including randomized controlled trials and observational studies.
ConclusionThe results consistently indicate significant improvements in the quality of life for patients with endometriosis. Yoga, as both a physical and mental practice, appears to be beneficial in managing pain. Although there are some limitations related to study design and variability, the evidence strongly supports the benefits of yoga in managing pelvic pain. Future research should focus on identifying which specific types of yoga practices offer the greatest benefits.
Effect of matcha green tea on cognitive functions and sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Authors: Uchida Kazuhiko , Meno Kohji , Korenaga Tatsumi , Liu Shan , Suzuki Hideaki , Baba Yoshitake , Tagata Chika , Araki Yoshiharu , Tsunemi Shuto , Aso Kenta , Inagaki Shun , Nakagawa Sae , Kobayashi Makoto , Kakuma Tatsuyuki , Asada Takashi , Ota Miho , Takihara Takanobu , Arai Tetsuaki 
Published: August 2024

Objective
Lifestyle habits after middle age significantly impact the maintenance of cognitive function in older adults. Nutritional intake is closely related to lifestyle habits; therefore, nutrition is a pivotal factor in the prevention of dementia in the preclinical stages. Matcha green tea powder (matcha), which contains epigallocatechin gallate, theanine, and caffeine, has beneficial effects on cognitive function and mood. We conducted a randomized, double-blind, placebo-controlled clinical study over 12 months to examine the effect of matcha on cognitive function and sleep quality.

Methods
Ninety-nine participants, including 64 with subjective cognitive decline and 35 with mild cognitive impairment were randomized, with 49 receiving 2 g of matcha and 50 receiving a placebo daily. Participants were stratified based on two factors: age at baseline and APOE genotype. Changes in cognitive function and sleep quality were analyzed using a mixed-effects model.

Results
Matcha consumption led to significant improvements in social acuity score (difference; -1.39, 95% confidence interval; -2.78, 0.002) (P = 0.028) as evaluated by the perception of facial emotions in cognitive function. The primary outcomes, that is, Montreal Cognitive Assessment and Alzheimer’s Disease Cooperative Study Activity of Daily Living scores, showed no significant changes with matcha intervention. Meanwhile, Pittsburgh Sleep Quality Index scores indicated a trend toward improvement with a difference of 0.86 (95% confidence interval; -0.002, 1.71) (P = 0.088) between the groups in changes from baseline to 12 months.

Conclusions
The present study suggests regular consumption of matcha could improve emotional perception and sleep quality in older adults with mild cognitive decline. Given the widespread availability and cultural acceptance of matcha green tea, incorporating it into the daily routine may offer a simple yet effective strategy for cognitive enhancement and dementia prevention.
JOGOS LÚDICOS COMO FERRAMENTA DE DESENVOLVIMENTO DO RACIOCÍNIO LÓGICO-MATEMÁTICO NAS SÉRIES FINAIS DO ENSINO FUNDAMENTAL I
Authors: Cerqueira Evelyn Mendes , Toledo Monize Aparecida de , Dantas Rafaela da Silva , Santos Raquel Pierini Lopes dos , Hees Luciane Weber Baia 
Published: August 2024

Este artigo discute o papel dos jogos lúdicos e as dificuldades que o professor enfrenta em sua ação no processo de desenvolvimento do raciocínio lógico-matemático. Trata-se de um estudo qualitativo de natureza exploratória no qual pretendeu-se, investigar como o jogo auxilia o processo de ensino-aprendizagem dos conteúdos de matemática nas séries finais do Ensino Fundamental e verificar a opinião dos professores de duas escolas particulares buscando identificar os obstáculos encontrados no momento de colocar em prática as atividades lúdicas. Concluiu-se que os professores encontram dificuldades para utilizar os jogos como ferramenta de ensino como: o tempo gasto com a preparação das atividades, a falta de recurso/matérias disponibilizados pela escola, as estratégias trabalhadas no cotidiano e também a competitividade existente entre os docentes. Entretanto, consideram os jogos como um recurso valioso no processo de ensino-aprendizagem.
FUNDO DE MANUTENÇÃO E DESENVOLVIMENTO DA EDUCAÇÃO BÁSICA E DE VALORIZAÇÃO DOS PROFISSIONAIS DA EDUCAÇÃO (FUNDEB)
Authors: Camargo Patricia de Lourdes , Barbosa Shirlei Cristina Rossete 
Published: August 2024

O FUNDEB é o Fundo de Manutenção e Desenvolvimento da Educação Básica e de valorização dos profissionais, tem como objetivo promover alguns incentivos econômicos para a concretização das políticas municipalizantes formuladas desde a Constituição Federal de 1988 e reforçada com a Lei de Diretrizes e Bases da Educação Nacional de 1996, do Estatuto da Criança e do Adolescente da Emenda Constitucional 14/1996, além de um conjunto de normas infraconstitucionais e resoluções do conselho Nacional de Educação. Pretende-se neste artigo refletir sobre o FUNDEB, seu contexto histórico, os avanços e as perspectivas deste para 2020. Após a realização de pesquisa bibliográfica, verificou-se que o financiamento da educação passou por diversas modificações desde o início da educação no Brasil até a promulgação do FUNDEB em 2007, este fundo garante o financiamento da educação básica pública, da educação infantil ao ensino médio e a Educação de Jovens e Adultos (EJA).
O ENSINO SUPERIOR NA AMERICA LATINA: INTERNACIONALIZAÇÃO, MERCADORIZAÇÃO E INCLUSÃO
Authors: Macedo Maria do Socorro Alencar Nunes 
Published: August 2024

A internacionalização do ensino superior na América Latina ocorre a passos lentos se comparada ao processo de Bolonha na Europa. Muitos são os documentos resultantes de acordos formais nas três últimas décadas entre os representantes dos diferentes países, com a participação de agências supranacionais como a UNESCO, o Banco Mundial, a CEPAL, O MERCOSUL, a UNASUL evidenciando uma tentativa de articulação para a criação de um espaço de educação superior para a região. Os desafios complexificam-se se levarmos em conta a necessária discussão das políticas de inclusão para o ensino superior implementadas a partir dos anos 2000, especialmente no Brasil, país que detém a mais robusta rede de instituições do ensino superior da região. Tal processo de inclusão não ocorreu sem a ampliação do processo de mercadorização do ensino superior, a partir do momento em que instituições privadas com fins lucrativos passaram a ter sua atuação regulamentada no Brasil.
UMA DISCUSSÃO SOBRE A NECESSIDADE DE INOVAÇÃO DISRUPTIVA NO ENSINO SUPERIOR BRASILEIRO
Authors: Machado Dinamara Pereira , Schneider Elton Ivan 
Published: August 2024

O ensino superior brasileiro vive uma verdadeira disrupção em sua forma de oferta de cursos, formas de gestão, uso de tecnologias, hibridismo, inovação e conta com o surgimento de um fenômeno novo, as megauniversidades de ensino a distância, instituições de ensino com mais de 100.000 alunos de graduação. As transformações e disrupções é que ainda não acabaram, na verdade estão em fase de ebulição, talvez em um momento de transformação, abrindo espaço para mais disrupções, uso de tecnologias, acessibilidade e inclusão social em todos os níveis. A metodologia adotada nesta pesquisa é de abordagem é de revisão teórica qualitativa. Neste artigo discute-se a educação a distância como inovação disruptiva. Após revisitarmos as bases teóricas e análise dos dados podemos afirmar que a realidade educacional superior brasileira passa por profundas transformações apresentando-se um novo cenário com seus desafios e perspectivas.
Digesting Digital Health: A Study of Appropriateness and Readability of ChatGPT-Generated Gastroenterological Information
Authors: Toiv Avi , Saleh Zachary , Ishak Angela , Alsheik Eva , Venkat Deepak , Nandi Neilanjan , Zuchelli Tobias E. 
Published: August 2024

INTRODUCTION:
The advent of artificial intelligence–powered large language models capable of generating interactive responses to intricate queries marks a groundbreaking development in how patients access medical information. Our aim was to evaluate the appropriateness and readability of gastroenterological information generated by Chat Generative Pretrained Transformer (ChatGPT).

METHODS:
We analyzed responses generated by ChatGPT to 16 dialog-based queries assessing symptoms and treatments for gastrointestinal conditions and 13 definition-based queries on prevalent topics in gastroenterology. Three board-certified gastroenterologists evaluated output appropriateness with a 5-point Likert-scale proxy measurement of currency, relevance, accuracy, comprehensiveness, clarity, and urgency/next steps. Outputs with a score of 4 or 5 in all 6 categories were designated as “appropriate.” Output readability was assessed with Flesch Reading Ease score, Flesch-Kinkaid Reading Level, and Simple Measure of Gobbledygook scores.

RESULTS:
ChatGPT responses to 44% of the 16 dialog-based and 69% of the 13 definition-based questions were deemed appropriate, and the proportion of appropriate responses within the 2 groups of questions was not significantly different (P = 0.17). Notably, none of ChatGPT’s responses to questions related to gastrointestinal emergencies were designated appropriate. The mean readability scores showed that outputs were written at a college-level reading proficiency.

DISCUSSION:
ChatGPT can produce generally fitting responses to gastroenterological medical queries, but responses were constrained in appropriateness and readability, which limits the current utility of this large language model. Substantial development is essential before these models can be unequivocally endorsed as reliable sources of medical information.