bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal Diagnosis of Neuroblastoma
Authors: Zvanca Mona , Andrei Cristian 
Published: November 2014

ABSTRACT
Fetal malignancies are rare complications during pregnancies, but when they appear, they are very challenging for the perinatology team. Because of their low incidence, the information is limited, with data provided from individual case reports or small case series. Although neuroblastoma is the most frequent extracranial solid tumor in childhood, prenatal diagnosis by ultrasound is very rare and almost always discovered during routine third trimester ultrasound. Expectant management is usually indicated prenatally, with serial ultrasound examination. Delivery should be planned in a tertiary center together with pediatric oncologists and surgeons to allow appropriate postnatal management. We present two cases of neuroblastoma diagnosed at 36 and 33 weeks of gestation with multiple aspects of this tumor identified by ultrasound. Both cases needed surgery and had a favorable outcome. The key role of ultrasound in diagnosis and follow-up of neuroblastoma in pregnancy is discussed, together with the management options recommended in literature.

How to cite this article
Andrei C, Vladareanu R, Zvanca M, Vladareanu S. Prenatal Diagnosis of Neuroblastoma. Donald School J Ultrasound Obstet Gynecol 2014;8(3):321-327.
Evaluation of a Pilot Parent-Delivered Play-Based Intervention for Children With Attention Deficit Hyperactivity Disorder
Authors: Wilkes-Gillan Sarah , Bundy Anita , Cordier Reinie , Lincoln Michelle 
Published: November 2014

Abstract
OBJECTIVE. This study evaluated a parent-delivered intervention aiming to address the social difficulties of children with attention deficit hyperactivity disorder (ADHD). The intervention was evaluated from three perspectives: effectiveness, feasibility, and appropriateness.
METHOD. This one-group pretest–posttest study included 5 children with ADHD and their parents, who had previously participated in a therapist-delivered play-based intervention. The 7-wk parent-delivered intervention involved home modules (including a DVD, manual, and play dates with a typically developing playmate) and three therapist-led clinic-based play sessions. The Test of Playfulness was used as a pre- and postintervention and follow-up measure. Parents were interviewed 1 mo following the intervention, and data were analyzed for recurring themes.
RESULTS. Children’s social play outcomes improved significantly from pretest to 1-mo follow-up (Z = 2.02, p = .04, d = 1.0). Three themes emerged: the clinic play environment as a sanctuary, parental barriers to intervention delivery, and tools for repeating learned lessons.
CONCLUSION. The parent-delivered intervention demonstrated preliminary evidence for feasibility and effectiveness. Further research is warranted regarding appropriateness.
Update on Productive Aging Research in the American Journal of Occupational Therapy, 2013, and Overview of Research Published 2009–2013
Authors: D’Amico Mariana 
Published: November 2014

Abstract
In light of the Centennial Vision charge of supporting practice through evidence, this article reviews productive aging research published in the American Journal of Occupational Therapy (AJOT) in 2013 and as a whole from 2009 to 2013. Thirteen such articles were published in 2013, consisting of 4 systematic reviews that identified effective occupational therapy interventions for older adults with low vision; 1 randomized controlled trial that examined changes in occupational therapists’ mental health practices with DVD training; and 8 descriptive articles addressing instrument development, practitioner decision making, patient management of medications, and effects of task activities on pain and participation levels. From 2009 to 2013, the quantity and quality of AJOT articles on productive aging increased; 63 articles were published, including 24 effectiveness studies, 14 basic research studies, 15 articles on instrument development and testing, 1 article linking occupational engagement and health, 6 articles on professional education, and 3 articles addressing professional questions.
A short tutorial contribution to impedance and AC-electrokinetic characterization and manipulation of cells and media: Are electric methods more versatile than acoustic and laser methods?
Authors: Gimsa Jan , Stubbe Marco , Gimsa Ulrike 
Published: November 2014

Abstract
Lab-on-chip systems (LOCs) can be used as in vitro systems for cell culture or manipulation in order to analyze or monitor physiological cell parameters. LOCs may combine microfluidic structures with integrated elements such as piezo-transducers, optical tweezers or electrodes for AC-electrokinetic cell and media manipulations. The wide frequency band (<1 kHz to >1 GHz) usable for AC-electrokinetic manipulation and characterization permits avoiding electrochemical electrode processes, undesired cell damage, and provides a choice between different polarization effects that permit a high electric contrast between the cells and the external medium as well as the differentiation between cellular subpopulations according to a variety of parameters. It has been shown that structural polarization effects do not only determine the impedance of cell suspensions and the force effects in AC-electrokinetics but can also be used for the manipulation of media with inhomogeneous temperature distributions. This manuscript considers the interrelations of the impedance of suspensions of cells and AC-electrokinetic single cell effects, such as electroorientation, electrodeformation, dielectrophoresis, electrorotation, and travelling wave (TW) dielectrophoresis. Unified models have allowed us to derive new characteristic equations for the impedance of a suspension of spherical cells, TW dielectrophoresis, and TW pumping. A critical review of the working principles of electro-osmotic, TW and electrothermal micropumps shows the superiority of the electrothermal pumps. Finally, examples are shown for LOC elements that can be produced as metallic structures on glass chips, which may form the bottom plate for self-sealing microfluidic systems. The structures can be used for cell characterization and manipulation but also to realize micropumps or sensors for pH, metabolites, cell-adhesion, etc.
Pulling Drugs along the Supply Chain: Centralization of Hospitals' Inventory
Authors: Iannone Raffaele , Lambiase Alfredo , Miranda Salvatore , Riemma Stefano , Sarno Debora 
Published: November 2014

Due to the economic crisis and the predominance of drug expenditure in healthcare costs, the cooperation of groups of hospitals to negotiate with suppliers and centralize warehouses has been a recent trend in the pharmaceutical supply chain. This paper shows the economic convenience of centralizing the hospitals' inventory decisions (how much/when to order) based on the sharing of medical prescriptions of patients along the supply chain. The logistic network under investigation (TO BE model) integrates: a central pharmacy negotiating with suppliers, collecting hospital orders, storing and distributing materials; a number of hospitals feeding their medical units with materials; and a number of medical units taking care of their patients. The study is carried out comparing the cost performances of the proposed model with a non-cooperative one(in which hospitals manage their stocks individually) by means of simulation.
Assessment of the Effectiveness of Maintenance-Oriented Design
Authors: Duraccio Vincenzo , Forcina Antonio , Silvestri Alessandro , Bona Gianpaolo Di 
Published: November 2014

This work aims to assess the impact of maintenance-oriented design on a production line in the pharmaceutical industry, which includes operations in a clean room. The case study analyses the downtimes of a production line of large volume parental solutions. The results obtained at the end of an appropriate period of observation were used to identify the main problems, in terms of maintenance time. Some of the critical issues were overcome by requiring that part of the production line be redesigned by a company specialized in the design of clean room lines. In this context, the focus of the case study is not on the technical aspects of maintenance-oriented design application, but its consequences in terms of the increase in performance. The performance of the new production line was analysed and compared with that obtained in the first phase of the study. This comparison allowed us to estimate and quantify the achieved improvements referring to system availability and consequently to a production increase quantified at more than 110,000 units per year. The impact of the maintenance-oriented design was also evaluated from an economic point of view. In particular, the production increase obtained and the corresponding economic advantages were evaluated. Through this comparison, it was possible to estimate the payback period for the investment of redesign, quantified in less than six years.
A Weighing Algorithm for Checking Missing Components in a Pharmaceutical Line
Authors: Silvestri Alessandro , Falcone Domenico , Cerbaso Cristina , Forcina Antonio 
Published: November 2014

To meet the requirements and specifications coming from the surrounding society, the socio-economic progress involves the development of new products, new technologies, new organizational forms etc. Companies are constantly looking for methods or procedures to improve production and income; but, the enterprise growth is strictly linked to the reliability of its internal processes. Internal failures can often cause loss of image. The goal of the present work is the development of an algorithm able to optimize the production line of a pharmaceutical firm. In particular, the proposed weighing procedure allows both checking missing components in packaging and minimizing false rejects of packages by dynamic scales. The main problem is the presence at the same time, in the same package, of different components with different variable weights. The consequence is uncertainty in recognizing the absence of one or more components.
Tissue-Engineered Vascular Grafts Created From Human Induced Pluripotent Stem Cells
Authors: Sundaram Sumati , One Jennifer , Siewert Joshua , Teodosescu Stephan , Zhao Liping , Dimitrievska Sashka , Qian Hong , Huang Angela H. , Niklason Laura 
Published: November 2014

Abstract

The utility of human induced pluripotent stem cells (hiPSCs) to create tissue-engineered vascular grafts was evaluated in this study. hiPSC lines were first induced into a mesenchymal lineage via a neural crest intermediate using a serum-free, chemically defined differentiation scheme. Derived cells exhibited commonly known mesenchymal markers (CD90, CD105, and CD73 and negative marker CD45) and were shown to differentiate into several mesenchymal lineages (osteogenic, chondrogenic, and adipogenic). Functional vascular grafts were then engineered by culturing hiPSC-derived mesenchymal progenitor cells in a pulsatile bioreactor system over 8 weeks to induce smooth muscle cell differentiation and collagenous matrix generation. Histological analyses confirmed layers of calponin-positive smooth muscle cells in a collagen-rich matrix. Mechanical tests revealed that grafts had an average burst pressure of 700 mmHg, which is approximately half that of native veins. Additionally, studies revealed that karyotypically normal mesenchymal stem cell clones led to generation of grafts with predicted features of engineered vascular grafts, whereas derived clones having chromosomal abnormalities generated calcified vessel constructs, possibly because of cell apoptosis during culture. Overall, these results provide significant insight into the utility of hiPS cells for vascular graft generation. They pave the way for creating personalized, patient-specific vascular grafts for surgical applications, as well as for creating experimental models of vascular development and disease.
Prevalência de traumatismo dentário e fatores associados em estudantes de 11 a 19 anos da zona rural do Município de Diamantina-MG
Authors: Reis Anderson Guimarães , Paiva Paula Cristina Pelli , Filho Paulo Messias Oliveira 
Published: November 2014

Objetivo: O objetivo do estudo foi investigar a prevalência de traumatismo dentário em escolares da área rural do município de Diamantina-MG e fatores associados. Materiais e Métodos: Estudo transversal foi desenvolvido em uma amostra de conveniência composta por 207 estudantes de 11-19 anos de idade. Dados foram coletados por meio de exame clínico e por questionários auto-aplicáveis. Foi adotado o critério de Andreasen et al. para classificação do traumatismo dentário, ABA-ABIPEME para condição socioeconômicae AUDIT para consumo de álcool. A análise dos dados foi realizada com o programa SPSS Statistical Package for the Social Sciences (SPSS for Windows, version 17,0, SPSS Inc, Chicago, IL, USA) e incluiu distribuiçãode freqüência e testes de associação. A significância estatística para a associação entre o traumatismo dentário e as variáveis independentes na análise bivariada foi determinada utilizando o teste do qui-quadrado (p <0,05). Associações foram testadas adotando o Modelo de Regressão de Poisson. Resultados: A prevalência do traumatismo dentário foi de 19,8% e teve associação estatisticamente significantiva com a idade (p=0,028),sobressaliência acima de 5 mm (p=0,026), proteção labial inadequada (p=0,039) e uso de álcool na vida (p=0,013). Os resultados da regressão logística de Poisson revelaram que a sobressaliência aumentada semanteve associado aos traumatismos dentários de forma independente às demais variáveis [PR = 2.90 (95% CI: 1.47 to 5.72) p = 0.0001]. Conclusão: A prevalência do traumatismo dentário foi elevada e esteve associadacom o uso na vida de álcool, sobressaliência acentuada e proteção labial inadequada.Descritores: Traumatismos dentários. Adolescente. Consumo de bebidas alcoólicas. Saúde pública. Saúde bucal.
Applying Particle Swarm Optimization for Solving Team Orienteering Problem with Time Windows
Authors: Ai The Jin , Mahulae Evan Martinus 
Published: November 2014

The Team Orienteering Problem With Time Windows (TOPTW) is a transportation problem case that have a set of vertices with a score, service time, and the time windows, start and final at a depot location. A number of paths are constructed to maximize the total collected score by the vertices which is visited. Each vertice can be visited only once and the visit can only start during the time window of vertices. This paper proposes a Particle Swarm Optimization algorithm for solving the TOPTW, by defining a specific particle for representing the solution of TOPTW within the PSO algorithm and two alternatives, called PSO_TOPTW1 and PSO_TOPTW2, for translating the particle position to form the routes of the path. The performance of the proposed PSO algorithm is evaluated through some benchmark data problem available in the literature. The computational results show that the proposed PSO is able to produce sufficiently good TOPTW solutions that are comparable with corresponding solutions from other existing methods for solving the TOPTW.
Liquid–Liquid Extraction
Authors: Pfennig* Andreas , Müller Eckart , Berger Rosemarie , Blass Eckhart , Sluyts Domien 
Published: August 2024

Abstract

The article contains sections titled:

1
Fundamentals and Fields of Application

2
Thermodynamic Fundamentals

2.1
Graphic Representation of Phase Equilibria

2.1.1
Triangular Diagrams

2.1.2
Other Graphic Representations

2.2
Measuring Methods of Phase Equilibria

2.3
Correlation of Phase Equilibria

2.4
Selection of Solvent

2.5
Determination of Mass‐Transfer Performance

2.5.1
Specific Methods for Determining the Number of Theoretical Stages

2.5.2
Determining Equipment Behavior Based on Drop‐Population Balances

2.5.3
Evaluation of Stage‐Number Calculation for Process Design

3
Apparatus

3.1
Survey

3.1.1
Columns Without Energy Input

3.1.2
Pulsed Columns

3.1.3
Columns with Rotating Internals

3.1.4
Mixer‐settlers

3.1.5
Centrifugal Extractors

3.2
Fluid‐Dynamic Fundamentals

3.2.1
Problems and Process Strategy

3.2.2
Operating Characteristics of Pulsed Columns and Columns with Rotating Internals

3.2.3
Fluid‐Dynamic Calculation Methods

3.3
Apparatus Design

3.3.1
Internals and Operating Conditions

3.3.2
Column Diameter

3.3.3
Column Height

3.4
Criteria for Equipment Selection

4
Phase‐Separation Equipment

4.1
Gravity Settlers Without Internals

4.2
Settlers with Coalescing Aids

4.3
Problems of Phase Separation

5
Liquid–Liquid Extraction Processes

5.1
General

5.2
Combined Processes of Extraction and Distillation

5.3
Reactive Extraction

5.3.1
Introduction

5.3.2
Extraction Mechanism of Different Types of Solvents

5.3.3
Diluents and Modifiers

5.3.4
Uses

5.3.5
Reaction‐Equilibrium Fundamentals

5.3.6
Setting up an Extraction System

Acknowledgment

References
Liquid‐Phase Exfoliation of 3D Metal–Organic Frameworks into Nanosheets
Authors: Ji Li‐Jun , Yang Tian‐Yi , Feng Guo‐Qiang , Li Sha , Li Wei , Bu Xian‐He 
Published: August 2024

AbstractTraditionally, the acquisition of 2D materials involved the exfoliation of layered crystals. However, the anisotropic bonding arrangements within 3D crystals indicate they are mechanically reminiscent of 2D counterparts and could also be exfoliated into nanosheets. This report delineates the preparation of 2D nanosheets from six representative 3D metal–organic frameworks (MOFs) through liquid‐phase exfoliation. Notably, the cleavage planes of exfoliated nanosheets align perpendicular to the direction of the minimum elastic modulus (Emin) within the pristine 3D frameworks. The findings suggest that the in‐plane and out‐of‐plane bonding forces of the exfoliated nanosheets can be correlated with the maximum elastic modulus (Emax) and Emin of the 3D frameworks, respectively. Emax influences the ease of cleaving adjacent layers, while Emin governs the ability to resist cracking of layers. Hence, a combination of large Emax and small Emin indicates an efficient exfoliation process, and vice versa. The ratio of Emax/Emin, denoted as Amax/min, is adopted as a universal index to quantify the ease of mechanical exfoliation for 3D MOFs. This ratio, readily accessible through mechanical experiments and computation, serves as a valuable metric for selecting appropriate exfoliation methods to produce surfactant‐free 2D nanosheets from various 3D materials.
Hyperband Synergistic Metadevices
Authors: Zhang Jin , Liu Peng , Xu Zhenyu , Dai Yawei , Zhang Qiang , Zhu Weiren , Kauppinen Esko I. , Sun Zhipei 
Published: August 2024

AbstractRecent advances in metadevices, featuring complex subwavelength metastructures, have dramatically transformed the control and manipulation of electromagnetic waves. However, the inherently narrow operational bandwidth of these devices, stemming from their wavelength‐specific meta‐atoms, restricts their application in rapidly advancing fields such as the Internet of Things and advanced intelligent systems. Here, a novel hyperband synergistic metadevice is introduced, realized through a comprehensive multi‐scale meta‐atom architecture. The complementary metal‐oxide‐semiconductor (CMOS)‐compatible prototype integrates the distinct properties of double‐walled carbon nanotubes with advanced interlayer and intralayer coupling mechanisms, coherently combining nanoscale, microscale, and macroscale meta‐atoms. This prototype is thus adept at operating across a wide electromagnetic spectrum, spanning from the centimeter‐wavelength microwave band to the hundred nanometer‐wavelength visible and infrared optical band. Significantly, this singular device synergistically delivers three critical functionalities: selective microwave absorption, efficient terahertz beam steering, and enhanced optical transparency. These result signifies a breakthrough in hyperband electromagnetic device engineering, leading to compact, versatile, intelligent electromagnetic platforms.
Top‐Layer Resonator Organic Distributed Feedback Laser for Label‐Free Refractive Index Sensing
Authors: Farrando‐Pérez Álex , Villalvilla José M. , Quintana José A. , Boj Pedro G. , Díaz‐García María A. 
Published: August 2024

AbstractSurface‐emitting organic distributed feedback (DFB) lasers are attractive devices for label‐free sensing applications. Of particular interest for cost‐reduction purposes are devices in which both active material and resonator are based on solution‐processable polymeric materials. Here, the capability for label‐free refractive index sensing of DFB devices consisting of top‐layer resonators (1D relief gratings) of dichromated gelatin layers is reported, deposited on top of active films of polystyrene doped with perylene orange. The devices show successful operation for both transversal electric and transversal magnetic modes, with a larger sensor sensibility for the latter (Sb = 38 nm RIU−1). The overall device operation (emission laser wavelength, laser threshold in addition to the sensitivity) has been optimized through the adjustment of the active film thickness and the grating period. This is possible thanks to the versatility offered by the holographic procedure used to fabricate the resonator, and to the top‐layer resonator geometry. Remarkably, the fact that the resonator is based on gelatin (a food‐grade biopolymer), offers great potential for the development of wearable and bio‐compatible sensing applications.
An Engineered Imine Reductase for Highly Diastereo‐ and Enantioselective Synthesis of β‐Branched Amines with Contiguous Stereocenters
Authors: Zhu Zhen‐Yu , Shi Min , Li Chen‐Lin , Gao Yun‐Fei , Shen Xin‐Yuan , Ding Xu‐Wei , Chen Fei‐Fei , Xu Jian‐He , Chen Qi , Zheng Gao‐Wei 
Published: August 2024

Abstractβ‐Branched chiral amines with contiguous stereocenters are valuable building blocks for preparing various biologically active molecules. However, their asymmetric synthesis remains challenging. Herein, we report a highly diastereo‐ and enantioselective biocatalytic approach for preparing a broad range of β‐branched chiral amines starting from their corresponding racemic ketones. This involves a dynamic kinetic resolution‐asymmetric reductive amination process catalyzed using only an imine reductase. Four rounds of protein engineering endowed wild‐type PocIRED with higher reactivity, better stereoselectivity, and a broader substrate scope. Using the engineered enzyme, various chiral amine products were synthesized with up to >99.9 % ee, >99 : 1 dr, and >99 % conversion. The practicability of the developed biocatalytic method was confirmed by producing a key intermediate of tofacitinib in 74 % yield, >99.9 % ee, and 98 : 2 dr at a challenging substrate loading of 110 g L−1. Our study provides a highly capable imine reductase and a protocol for developing an efficient biocatalytic dynamic kinetic resolution‐asymmetric reductive amination reaction system.