bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between echocardiography-derived haemodynamic force parameters and left ventricular reverse remodelling after cardiac resynchronization therapy
Authors: Laenens Dorien , van der Bijl Pieter , Galloo Xavier , Rossi Alessandro C , Tonti Giovanni , Reiber Johan H C , Pedrizzetti Gianni , Ajmone Marsan Nina , Bax Jeroen J 
Published: July 2024

Abstract

Aims
Cardiac resynchronization therapy (CRT) may induce left ventricular (LV) reverse remodelling (=LV response) in patients with heart failure. Intraventricular pressure gradients can be quantified using echocardiography-derived haemodynamic forces (HDF). The aim was to evaluate the association between baseline HDF and LV response and to compare the change of HDF after CRT between LV responders and LV non-responders.

Methods and results
The following HDF parameters were assessed: (i) apical–basal (AB) strength, (ii) lateral–septal strength, (iii) force vector angle, (iv) systolic AB impulse, (v) systolic force vector angle. LV response was defined as a reduction of LV end-systolic volume ≥ 15% at six months. One hundred ninety-six patients were included [64 ± 11 years, 122 (62%) men], 136 (69%) showed LV response. On multivariable logistic regression analysis, the force vector angle in the complete heart cycle [OR 1.083 (95% CI: 1.018, 1.153), P = 0.012] and the systolic force vector angle [OR 1.089 (95% CI: 1.021, 1.161), P = 0.009], both included in separate models, were independently associated with LV response. Six months after CRT, LV responders had greater AB strength, AB impulse, and higher force vector angles, while LV non-responders only showed improvement in the force vector angle in the complete heart cycle.

Conclusion
The orientation of HDF at baseline is associated with LV response to CRT. Six months after CRT, the orientation of HDF improves in LV responders and LV non-responders, while the magnitude of AB HDF only improves in LV responders.
Managing a patient with pulmonary thromboembolic disease presenting with active haemoptysis: a case report
Authors: Jung Moon-Kyung , Kim Hwan Wook , Beck Kyongmin S , Sung Yeoun Eun , Jung Mi-Hyang 
Published: July 2024

Abstract

Background
Pulmonary thromboembolism and active haemoptysis represent distinct yet critical emergencies necessitating immediate intervention. However, the treatment protocols for these conditions—anticoagulation therapy and haemostatic therapy—often pose a dilemma.

Case summary
We present the case of a 25-year-old female who presented to our emergency room with haemoptysis and a concurrent diagnosis of pulmonary thromboembolism. Due to persistent active haemoptysis, we temporarily paused anticoagulation and opted for surgical pulmonary thrombectomy, enabling the safe resumption of anticoagulation therapy.

Discussion
Haemoptysis occurring in pulmonary thromboembolism is infrequently reported in the literature, and established treatment guidelines for such cases are lacking. This case could provide guidance on how to handle the intricate treatment challenges posed by concurrent haemoptysis and pulmonary thromboembolism.
SARS-CoV-2 vaccine hesitancy and its relationship with health-related quality of life in patients with heart failure - pilot cross-sectional study
Authors: Sawczak F , Soloch A , Halas M , Cierzniak M , Szubarga A , Kukfisz A , Tomaszewska M , Dudek M , Straburzynska-Migaj E , Kaluzna-Oleksy M 
Published: July 2024

Abstract

Introduction
Heart failure (HF) is a complex disease which influences various aspects of life. The latest COVID-19 outbreak exposed that HF patients were at higher risk of severe outcomes and mortality after being infected with SARS-CoV-2. Therefore, vaccination against SARS-CoV-2 is particularly recommended in that group. However, vaccine hesitancy is a growing problem, and it also affects vulnerable HF patients. Health-related quality of life (HRQoL) may be related to the resignation from vaccination against SARS-CoV-2.

Purpose
The study aims to assess the relationship between avoiding vaccinations against SARS-CoV-2 and HRQoL using the World Health Organisation Quality of Life Brief questionnaire of Life Brief (WHOQOL-BREF) in patients with heart failure.

Methods
To evaluate the HRQoL, the WHOQOL-BREF questionnaire was used. 117 patients hospitalized with a diagnosis of HF in 2022 irrespectively of left ventricle ejection fraction (LVEF) at the cardiology department were interviewed. Additionally, a detailed medical history was collected. Until the beginning of 2022, all patients could receive the vaccine. Patients were divided into two groups - vaccinated against SARS-CoV-2 and unvaccinated. HRQoL domain scores and total HRQoL were compared between the mentioned groups using the U-Mann Whitney test.

Results
The mean age of enrolled patients was 55.3±17.4 years, 21.4% were women, and the mean LVEF was 30.3±14.4%. 13 (11.1%) patients were not vaccinated against SARS-CoV-2 at the time of the interview. There was no difference in total HRQoL (p=0.437) and individual domains scores: somatic (p=0.787), psychological (p=0.171), social (p=0.261) and environmental (p=0.834) between both study groups. Patients avoiding vaccination against SARS-CoV-2 compared to vaccinated patients were younger (39.7±13.8 years vs. 57.3±6.9 years, p&lt;0.001) and had lower LVEF (23.8±14.0% vs. 31.3±14.3%; p=0.04). In the unvaccinated group of patients, the duration of HF was three times shorter (mean 4.3 vs.12.4 years, p=0.002).

Conclusions
The study revealed no differences in domains of the WHOQoL-BREF questionnaire and overall HRQoL between patients who decided to vaccinate and those with the opposite decision. Almost 90% of the patients with HF were vaccinated against SARS-CoV-2. Younger HF patients are more hesitant to vaccinate against SARS-CoV-2, which is consistent with the trend observed in HF patients [1] and the general population [2]. Further studies could better characterize the patients with heart failure who are vaccine-hesitant. Eventually, it could help develop more specific care to convince them to vaccinate.
The effectiveness of supportive management programs in caregivers of patients with heart failure: a systemartic review
Authors: Vouri N , Kyriakou M , Hadjiyiasemi K , Malaktou A , Philippou K , Sourtzi P , Lambrinou E 
Published: July 2024

Abstract

Introduction
Supportive management programs involving caregivers of heart failure (HF) patients may be beneficial not only for the patient, but also for the caregiver. This study aims to investigate the effectiveness of supportive management programs for caregivers in terms of quality of life (QoL), depressive and/or anxiety symptoms and caregivers’ burden.

Methods
A systematic review was conducted in order to identify interventional studies delivering supportive management programs to dyads and evaluating the effectiveness for caregivers in terms of their QoL, depressive symptoms and burden. A systematic search in PubMed, CINAHL, and the Cochrane Library was performed. Inclusion and exclusion criteria and the Preferred Reporting Items (PRISMA) statement checklist were used. Fourteen randomized (RCT’s) and interventional studies were included.

Results
Fourteen articles were included in the review from a pool of thirty-five papers. A large heterogeneity was observed among the studies regarding several aspects; the intervention as such (e.g psychological support, cognitive behavioral therapy), the duration of the follow- up period and the method that the intervention was delivered (e.g telephone conducts, home visits). Another striking feature was the variety of outcomes that were studied. The most common outcomes were: anxiety and depressive symptoms, burden and impaired quality of life.

Conclusions
Supportive care management programs are beneficial for both, the patients and the caregivers. It provides the supporting environment for the best possible results and outcomes and most importantly quality of life of the patients and the caregivers.
Smoking and risk for morbidity and mortality in patients who undergoes coronary artery bypass grafting
Authors: Johansson E , Stenman M , Hansson E C , Malm C J , Jeppsson A , Nielsen S J 
Published: July 2024

Abstract

Background
The association between smoking and prognosis after coronary artery bypass grafting (CABG) is sparsley studied. The few previous studies investigating this association show conflicting results.

Purpose
The purpose was to explore the association between smoking and long-term risk for morbidity and mortality in patients undergoing CABG.

Methods
Data from the SWEDEHEART registry were used to identify all patients who underwent isolated CABG in Sweden from 1992 to 2020 and smoking status at time for surgery. Three other mandatory national registries were used to collect data for comorbidities, social factors, and death (Swedish National Inpatient Register, Longitudinal Integration Database for Health Insurance and Labor Market Studies and, Swedish Cause of Death Register). Cox regression models adjusted for age and sex, comorbidities and social factors were used to assess the risk for all cause death, stroke, myocardial infarction. Mean follow-up time was 5.2 years (range 0-10).

Results
In total, 27,434 patients aged &gt;18 years were identified (18.2% women). The study population was divided into; never smoker (n=8593), former smoker (n=14666) and current smoker (n=4175). The proportion of previous ST Elevation Myocardial Infarction (STEMI), heart failure, previous stroke, peripheral vascular disease, chronic respiratory disease, depression, low education was higher in current smokers than in non-smokers. Compared to never smokers, current smokers had a higher risk for all-cause death (adjusted Hazard ratio (aHR) 1.36 (95% Confidence interval (CI) (1.22-1.52)) and stroke (aHR 1.39 (1.18-1.64)) but not for myocardial infarction (aHR 1.03 (0.87-1.21). Former smoker had higher risk for all cause death (aHR1.17 (1.08-1.28)) compared to never smokers but no increased risk for myocardial infarction 0.91 (0.81-1.03) and stroke (aHR 1.11 (0.98-1.25).

Conclusion
There is a strong association between smoking at the time for surgery and long-term risk for worse prognosis after CABG. The results emphasize the importance of encouraging and motivate CABG patients to smoking cessation.
Patients' perspectives on feedback interventions to support adherence to long-term medication: a systematic review with thematic synthesis of qualitative evidence
Authors: Kobson B , Paterson R , Hanley J , Mair A , Dima A , Rea N 
Published: July 2024

Abstract

Background
Medication optimisation is a global issue with up to 50% of people not taking medicines as prescribed. Numerous interventions have been developed to address this, many of them including feedback on behaviour and outcomes. Understanding patients’ views on such interventions is essential for successful adoption and use.

Purpose
The purpose of this systematic review is to: (1) Understand patients’ perspectives and experiences of medication adherence feedback interventions and (2) Identify barriers and facilitators which influence their implementation within practice.

Methods
CINAHL, MEDLINE, EMBASE, PubMED, PsycINFO and Google Scholar were systematically searched to identify relevant studies. The inclusion criteria included; studies with qualitative or mixed method designs describing patients’ perspectives on medication adherence feedback interventions, primary studies with adult participants on long-term medications and studies involving interventions suitable for self-management in primary or community care. Quality assessment was completed using the Mixed Methods Appraisal Tool. The review was reported using the PRISMA and conducted using ENTREQ guidelines. Data were extracted and analysed using thematic synthesis (NVivo 20). Findings were presented narratively.

Results
From the 1,031 records screened, ten studies were included. Five studies were conducted in the United States, two in the United Kingdom, and one in the Netherlands, Canada, and Tanzania, respectively. Medication adherence interventions included the use of therapeutic drug monitoring methods and digital adherence technologies such as mHealth and eHealth for people living with asthma, HIV, coronary heart disease, hypertension, and type 2 diabetes. Patients found interventions acceptable if they were simple to use, allowed control over data sharing options, incorporated audio visual cues, and provided emotional and motivational support. Building trust between patients and healthcare providers and the resulting benefit of shared decision-making were also considered key factors for intervention success. However, developing interventions without user input was identified as a potential barrier to intervention implementation. Patients expressed an overall desire to have interventions tailored to meet their personal needs and preferences, highlighting the importance of placing user needs at the centre of intervention development.

Conclusion
Placing user needs at the centre of adherence intervention development is crucial for successful implementation. Further research which facilitates user involvement in co-designing interventions to compliment patients’ characteristics and preferences would be key for intervention implementation.
Assessing the information needs of patients implanted with a left ventricular assist device via analysis of social media forums
Authors: Abdelhadi N , Klein S , Shahar M , Melnikov S 
Published: July 2024

Abstract

Background
Left Ventricular Assist Devices (LVADs) serve as a feasible treatment alternative for patients with end-stage heart failure who do not respond sufficiently to maximal medical therapy. An increasing number of individuals with end-stage heart failure, both pre- and post-LVAD implantation, are utilizing social media to find medical information and peer support.

Purpose
The objective of this study was to identify unmet education and information needs of patients with LVAD through social media interactions.

Methods
In this research, information was gathered from the forum section of the website MyLVAD.com through an automated extraction technique. We conducted an anonymous collection and analysis of a dataset from MyLVAD.com, which comprised 459 forum threads and 3886 messages across the entire forum, contributed by 945 unique users. To establish a matrix addressing existing information and educational needs, we examined 867 posts and conversations that contained questions and inquiries, ultimately identifying a total of 435 concrete questions. A series of categorization matrices were developed and updated to facilitate the discovery of new categories.

Results
Numerous information gaps and unanswered questions were discovered in relation to the following areas: clothing, complications/adverse events, LVAD pros and cons, self-care, therapy, and recent LVAD implantation. Among the 435 questions, 216 (49.7%) questions had a primary focus on self-care for patients with LVAD, including subjects such managing the driveline site, understanding equipment functionality, and adapting lifestyle habits to ensure safety and health while living with an LVAD. Two other major question categories emerged: those regarding complications/adverse effects, comprising 80 questions (18.4%), and those discussing the pros and cons of LVAD, with 67 questions, accounting for 15.4%.

Conclusion
The social media data retrieved from MyLVAD.com is the first to be used to assess the unmet needs and knowledge gaps among patients implanted with LVAD and develop categories to describe LVAD patient knowledge and information needs. Unlike investigator-generated data, social media data reflect the natural and organic conversation between patients, untainted by investigator agendas or biases. Social media data can enhance our understanding of patient information deficiencies. This can lead to the creation of materials specifically aimed at fulfilling unaddressed educational requirements.Unmet LVAD patients information needs
The impact of frailty syndrome on the occurrence of anxiety disorders and depression in patients with arterial hypertension
Authors: Jarosz K , Kogut P , Mazgaj S , Moryn K , Mlynarska A 
Published: July 2024

Abstract

In recent years, there has been an increase in the number of older people, which translates into more frequent diagnosis of frailty among geriatric patients. Anxiety and depressive disorders in geriatric patients very often lead to deterioration of their health and exacerbation of chronic diseases, which results in deterioration of their functioning. The aim of the study was to assess the impact of frailty syndrome on the occurrence of anxiety and depressive disorders among patients with diagnosed hypertension.

Material and methods
The study included 70 patients with diagnosed hypertension (39 women - 56% and 31 men - 44%, aged between 60 and 92 years). The mean age of those included in the study was 70.3 ± 7.3 years.

Results
Frailty syndrome was diagnosed in 75.7% of patients participating in the study (77.4% of men and 74.3% of women). Depressive disorders occurred in 28.5% of respondents, including 25.8% of men and 30.8% of women. Anxiety disorders occurred in 24.3% of people, interestingly, men predominated in this group - 32.2%, while there were 17.9% of women with anxiety disorders. It has been shown that in women there is a relationship between the occurrence of frailty and depression in the general frailty syndrome and the physical and psychological domains. However, there is no statistically significant relationship between TFI in the social domain and the occurrence of depression. In this group of respondents, there was a statistically significant correlation between TFI and anxiety only in the psychological domain. There was no correlation between general frailty, physical and social domains and the occurrence of the drug. There is no statistically significant correlation between frailty syndrome and its domains and the occurrence of depressive disorders. A statistically significant relationship appears only between the physical and psychological domains and anxiety.

Conclusions
In women, weakness in the physical and psychological domain influences the development of depression, while in the case of anxiety it affects only the psychological domain. In men, frailty does not influence the occurrence of depressive disorders. Among men, there is a statistically significant correlation between physical and psychological frailty and anxiety.
Assessment of pain intensity and analgesic requirements in patients with diabetes mellitus after STEMI
Authors: Pustelak K 
Published: July 2024

Abstract

Introduction
Patients with diabetes encounter a significantly higher risk of myocardial infarction, heart failure, and mortality following acute cardiac events. Examining pain intensity and analgesic needs in patients with diabetes can provide a comprehensive understanding of the pain experienced and individual analgesic needs in patients with diabetes.

Aim of the study
The aim was to assess pain intensity and analgesic requirements in patients with diabetes mellitus after STEMI.

Material and Methods
The study involved 104 participants (58 female and 46 male, with a mean age of approximately 72 years, M±SD= 11 yeas). The study was conducted at the Heart Institute, in the Intensive Cardiology Unit, and data were collected from patients following STEMI Participants were divided into two groups:
54 people with diabetes and 50 people without diabetes. The influence of factors such as gender, age, existing diseases, haemoglobin levels and the presence of diabetes on pain intensity was analysed.
In the diabetes group, the effects of treatment method, duration of illness and diabetes compliance on pain intensity were also considered. A visual analogue scale (VAS) was used to assess pain, and analgesia requirement was assessed using an analgesic ladder.
The level of significance wasp &lt; 0.05.

Results
The analysis indicated the effect of diabetes on pain intensity in patients with myocardial infarction. Those with diabetes experienced significantly less pain, however glycated HbA1c levels above 7.0 mg/dl predisposed to experiencing more pain. The b standardized regression coefficient indicated for diabetes ,a strong negative correlation (β=-0.77 ,p = 0,008), and for HbA1c level ,a strong positive correlation (β=0.88 ,p =0,889). Comparative analysis of analgesics revealed lower usage in the diabetes group(p=0.002). Diabetes Patients, the most frequent use of first-line drugs while the group of patients without diabetes needed second-level analgesic treatment. Those with diabetes rated their pain level as low ,while the non-diabetic group was dominated by respondents with an intermediate pain level. Non-adherence to diabetic recommendations correlated with higher pain intensity , with a strong positive correlation (β coefficient=0.90, p = 0,010 ). No significant impact was observed based on gender, age, the presence of comorbidities, or the influence of diabetes treatment methods and duration on the intensity of perceived pain.

Conclusions
The analysis indicated the effect of diabetes on pain intensity in patients with myocardial infarction. Those with diabetes experienced significantly less pain than non-diabetes patients. Diabetes patients required a lower level of the analgesics ladder.
The associationof quality of life and the functioning in the chronic disease among patients after myocardial infarction
Authors: Kolarczyk E B , Kohanova D , Witkowska A , Szymiczek M , Mlynarska A 
Published: July 2024

Abstract

Background
The importance of health-relatedquality of life (HRQoL) and improving functional status in reducing risk factors of myocardial infarction (MI) has also been increasingly recognized.

Purpose
This study aimed to examine the level of quality of life (QoL) in patients after myocardial infarction (MI) in relation to the degree of functioning in chronic disease.

Methods
This was a cross-sectional, single-centre study. The study was conducted among 231 patients who were hospitalized for myocardial infarction (MI) after percutaneous coronary intervention (PCI). The WHO Quality of Life Questionnaire (WHOQOL BREF) andthe Chronic Disease Functioning Scale(FCIS) were used.

Results
The Spearman's correlation coefficient showed a statistically significant correlation (coefficient value 0.5 &lt; |r/rho| ≤ 0.7) between general functioning in chronic disease and the average QoL (rho = 0.56;p &lt; 0.001)and somatic QoL levels(rho = 0.52;p &lt; 0.001), as well as a moderately strong positive correlation with the QoL level on the psychological domain (rho = 0.50;p &lt; 0.001), social domain (rho = 0.48;p &lt; 0.001) and environmental domain (rho = 0.43;p &lt; 0.001).

Conclusion
Identifying the chronic disease functioning indicator in post-MI patients in relation to HRQoL allows for targeted counseling and secondary prevention of ischemic heart disease (IHD), which translates into a reduced risk of further cardiovascular events and related rehospitalization.