bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial and Ethnic Differences in Older Adults With Knee Osteoarthritis
Authors: Cruz‐Almeida Yenisel , Sibille Kimberly T. , Goodin Burel R. , Petrov Megan E. , Bartley Emily J. , Riley Joseph L. , King Christopher D. , Glover Toni L. , Sotolongo Adriana , Herbert Matthew S. , Schmidt Jessica K. , Fessler Barri J. , Staud Roland , Redden David , Bradley Laurence A. , Fillingim Roger B. 
Published: April 2014

ObjectiveKnee osteoarthritis (OA) contributes significantly to disability in older individuals, and racial/ethnic minorities are disproportionately affected. The present study aimed to characterize differences in clinical and experimental pain, including pain inhibition, among older African American (AA) and non‐Hispanic white (NHW) subjects with knee OA.MethodsAA and NHW subjects with knee OA (n = 267) completed clinical and functional pain assessments, including quantitative sensory testing (QST). We hypothesized that, when compared to NHW subjects, AA subjects would display 1) lower pain tolerance and higher ratings of heat‐, mechanical‐, and cold‐induced pain, 2) greater temporal summation of pain, 3) reduced pain inhibition, and 4) greater clinical pain and poorer function. In addition, we hypothesized that the findings from QST would significantly predict the severity of clinical pain within each race/ethnicity.ResultsAA subjects with knee OA displayed increased pain sensitivity, greater temporal summation, and reduced pain inhibition when compared to NHW subjects with knee OA. Moreover, AA subjects reported greater clinical pain and poorer function. Racial/ethnic differences in clinical pain became nonsignificant when the analyses were controlled for education and annual income, whereas differences in QST findings remained highly significant. Although the extent of pain inhibition predicted the severity of clinical pain in both groups, different QST measures were additionally predictive of clinical pain within each group.ConclusionThe results of this study establish that there are racial/ethnic differences in experimental and clinical pain and function in older individuals with knee OA. Our findings indicating that different QST measures were associated with clinical pain within the 2 racial/ethnic groups, whereas reduced pain inhibition was important in all participants, warrant further study in order to elucidate the common and group‐specific pathophysiologic mechanisms contributing to clinical pain in OA.
Low‐Dose Irinotecan Improves Advanced Lupus Nephritis in Mice Potentially by Changing DNA Relaxation and Anti–Double‐Stranded DNA Binding
Authors: Frese‐Schaper Manuela , Keil Andreas , Steiner Selina K. , Gugger Mathias , Körner Meike , Kocher Gregor J. , Schiffer Lena , Anders Hans‐Joachim , Huynh‐Do Uyen , Schmid Ralph A. , Frese Steffen 
Published: April 2014

ObjectiveDespite clear advances in the treatment of systemic lupus erythematosus (SLE), many patients still present with refractory lupus nephritis, requiring new treatment strategies for this disease. This study was undertaken to determine whether reduced doses of the topoisomerase I (topo I) inhibitor irinotecan, which is known as a chemotherapeutic agent, suppress SLE in (NZB × NZW)F1 (NZB/NZW) mice, and to evaluate the potential mechanism by which irinotecan influences the course of SLE.MethodsNZB/NZW mice were treated with low‐dose irinotecan beginning at either 24 weeks of age or established glomerulonephritis, defined as proteinuria of grade ≥3+. Binding of anti–double‐stranded DNA (anti‐dsDNA) antibodies was measured by enzyme‐linked immunosorbent assay (ELISA), and DNA relaxation was visualized by gel electrophoresis.ResultsSignificantly reduced irinotecan doses improved lupus nephritis and prolonged survival in NZB/NZW mice. The lowest dose successfully used for the treatment of established murine lupus nephritis was >50 times lower than the dose usually used for chemotherapy in humans. As a mechanism, low‐dose irinotecan reduced B cell activity. However, the levels of B cell activity in irinotecan‐treated mice were similar to those in BALB/c mice of the same age, suggesting that irinotecan did not induce clear immunosuppression. In addition, incubation of dsDNA with topo I increased binding of murine and human anti‐dsDNA antibodies, showing for the first time that relaxed DNA is more susceptible to anti‐dsDNA antibody binding. This effect was reversed by addition of the topo I inhibitor camptothecin.ConclusionOur findings indicate that topo I inhibition may be a novel and targeted therapy for SLE.
SnS2 Nanoplatelet@Graphene Nanocomposites as High‐Capacity Anode Materials for Sodium‐Ion Batteries
Authors: Xie Xiuqiang , Su Dawei , Chen Shuangqiang , Zhang Jinqiang , Dou Shixue , Wang Guoxiu 
Published: April 2014

AbstractNa‐ion batteries have been attracting intensive investigations as a possible alternative to Li‐ion batteries. Herein, we report the synthesis of SnS2 nanoplatelet@graphene nanocomposites by using a morphology‐controlled hydrothermal method. The as‐prepared SnS2/graphene nanocomposites present a unique two‐dimensional platelet‐on‐sheet nanoarchitecture, which has been identified by scanning and transmission electron microscopy. When applied as the anode material for Na‐ion batteries, the SnS2/graphene nanosheets achieved a high reversible specific sodium‐ion storage capacity of 725 mA h g−1, stable cyclability, and an enhanced high‐rate capability. The improved electrochemical performance for reversible sodium‐ion storage could be ascribed to the synergistic effects of the SnS2 nanoplatelet/graphene nanosheets as an integrated hybrid nanoarchitecture, in which the graphene nanosheets provide electronic conductivity and cushion for the active SnS2 nanoplatelets during Na‐ion insertion and extraction processes.
FDI Design for Uncertain Nonlinear Systems with Both Actuator and Sensor Faults
Authors: Yang Junqi , Zhu Fanglai 
Published: April 2014

AbstractThis paper considers the problems of simultaneous actuator and sensor fault detection and isolation (FDI) for a class of uncertain Lipschitz nonlinear systems when the observer matching condition is not satisfied. An augmented vector is proposed to construct an augmented system that contains a fault vector consisting of both the actuator and sensor faults of the original system. An auxiliary output vector is constructed to satisfy the observer matching condition, and a high‐gain sliding mode observer is designed to approximately estimate the auxiliary output vector. An adaptive robust sliding mode observer is developed as a fault detector to detect the actuator and sensor faults simultaneously. Then, multi‐observers are designed to attain the actuator and sensor fault isolation purpose. Finally, a numerical simulation is given to show the effectiveness of the proposed methods.
Strong subsurface soil temperature feedbacks on summer climate variability over the arid/semi‐arid regions of East Asia
Authors: Wu Lingyun , Zhang Jingyong 
Published: April 2014

AbstractTwo long‐term regional climate model simulations with and without subsurface soil temperature feedbacks are performed to investigate the role of soil temperature–atmosphere coupling in influencing interannual variability of summer climate over East Asia. Results indicate that soil temperature–atmosphere coupling depends on climate regimes, mainly affecting summer climate variability over the arid/semi‐arid regions. Over these areas, subsurface soil temperature feedbacks play an important role in amplifying summer surface air temperature variability, accounting for about 30–70% of total variance. The feedbacks on precipitation variability are weaker than those on surface air temperature variability over the arid/semi‐arid regions, but are still significant over many areas of western part.
Epidemiology of multiple congenital anomalies in Europe: A EUROCAT population‐based registry study
Authors: Calzolari Elisa , Barisic Ingeborg , Loane Maria , Morris Joan , Wellesley Diana , Dolk Helen , Addor Marie‐Claude , Arriola Larraitz , Bianchi Fabrizio , Neville Amanda J. , Budd Judith L.S. , Klungsoyr Kari , Khoshnood Babak , McDonnell Bob , Nelen Vera , Queisser‐Luft Annette , Rankin Judith , Rissmann Anke , Rounding Catherine , Tucker David , Verellen‐Dumoulin Christine , de Walle Hermien , Garne Ester 
Published: April 2014

BackgroundThis study describes the prevalence, associated anomalies, and demographic characteristics of cases of multiple congenital anomalies (MCA) in 19 population‐based European registries (EUROCAT) covering 959,446 births in 2004 and 2010.MethodsEUROCAT implemented a computer algorithm for classification of congenital anomaly cases followed by manual review of potential MCA cases by geneticists. MCA cases are defined as cases with two or more major anomalies of different organ systems, excluding sequences, chromosomal and monogenic syndromes.ResultsThe combination of an epidemiological and clinical approach for classification of cases has improved the quality and accuracy of the MCA data. Total prevalence of MCA cases was 15.8 per 10,000 births. Fetal deaths and termination of pregnancy were significantly more frequent in MCA cases compared with isolated cases (p < 0.001) and MCA cases were more frequently prenatally diagnosed (p < 0.001). Live born infants with MCA were more often born preterm (p < 0.01) and with birth weight < 2500 grams (p < 0.01). Respiratory and ear, face, and neck anomalies were the most likely to occur with other anomalies (34% and 32%) and congenital heart defects and limb anomalies were the least likely to occur with other anomalies (13%) (p < 0.01). However, due to their high prevalence, congenital heart defects were present in half of all MCA cases. Among males with MCA, the frequency of genital anomalies was significantly greater than the frequency of genital anomalies among females with MCA (p < 0.001).ConclusionAlthough rare, MCA cases are an important public health issue, because of their severity. The EUROCAT database of MCA cases will allow future investigation on the epidemiology of these conditions and related clinical and diagnostic problems. Birth Defects Research (Part A) 100:270–276, 2014. © 2014 Wiley Periodicals, Inc.
Rapid communication capturing the destabilizing effect of dihydrouridine through molecular simulations
Authors: Deb Indrajit , Sarzynska Joanna , Nilsson Lennart , Lahiri Ansuman 
Published: April 2014

ABSTRACTThe structural effects of the commonly occurring modified nucleoside dihydrouridine (D) observed experimentally in model oligonucleotides include a strong destabilization of the C3′‐endo sugar conformation of D, the disruption of stacking interactions of neighboring residues with D and a possible destabilization of the C3′‐endo sugar pucker of the 5′‐neighboring nucleoside. Our simulations with a combination of a set of parameters for modified RNA residues with the recently developed AMBER FF99χ force field having reoptimized glycosidic torsion angle parameters for standard nucleosides was found to reproduce the destabilizing effect of dihydrouridine better than with the AMBER FF99 force field for nucleic acids for which the parameters for the modified residues were originally developed. © 2014 Wiley Periodicals, Inc. Biopolymers 101: 985–991, 2014.
Relative stability of G‐quadruplex structures: Interactions between the human Bcl2 promoter region and derivatives of carbazole and diphenylamine
Authors: Sheu Sheh‐Yi , Huang Chao‐Hsien , Zhou Jia‐Kai , Yang Dah‐Yen 
Published: April 2014

ABSTRACTThe bcl2 promoter region forms a G‐quadruplex structure, which is a crucial target for anticancer drug development. In this study, we provide theoretical predictions of the stability of different G‐quadruplex folds of the 23‐mer bcl2 promoter region and G‐quadruplex ligand. We take into account the whole G‐quadruplex structure, including bound‐cations and solvent effects, in order to compute the ligand binding free energy using molecular dynamics simulation. Two series of the carbazole and diphenylamine derivatives are used to screen for the most potent drug in terms of stabilization. The energy analysis identifies the predominant energy components affecting the stability of the various different G‐quadruplex folds. The energy associated with the stability of the G‐quadruplex‐K+ structures obtained displays good correlation with experimental Tm measurements. We found that loop orientation has an intrinsic influence on G‐quadruplex stability and that the basket structure is the most stable. Furthermore, parallel loops are the most effective drug binding site. Our studies also demonstrate that rigidity and planarity are the key structural elements of a drug that stabilizes the G‐quadruplex structure. BMVC‐4 is the most potential G‐quadruplex ligand. This approach demonstrates significant promise and should benefit drug design. © 2014 Wiley Periodicals, Inc. Biopolymers 101: 1038–1050, 2014.
Stability and degradation patterns of chemically modified analogs of apelin‐13 in plasma and cerebrospinal fluid
Authors: Murza Alexandre , Belleville Karine , Longpré Jean‐Michel , Sarret Philippe , Marsault Éric 
Published: April 2014

ABSTRACTApelin is the endogenous ligand of APJ, which belongs to the superfamily of G protein‐coupled receptors. In recent years, the apelin/APJ system has been detected in many tissues and emerges as a promising target for the treatment of various pathophysiological conditions. Pyr1‐apelin‐13 is the major isoform of apelin in human plasma; however its stability and proteolytic degradation pattern remain poorly understood. The aim of the present study was first to identify the cleavage sites of Pyr1‐apelin‐13 in mouse, rat and human plasma and rat cerebrospinal fluid, then to determine its stability to proteolytic degradation following intravenous administration in rats. Secondly, key residues were substituted by natural and unnatural amino acids in order to examine the impact onin vitrostability and degradation pattern. The kinetics of degradation revealed that the Leu5‐Ser6 peptide bond of Pyr1‐apelin‐13 is the first cleavage observed in plasma, independently of the species. Replacement of Phe13 by unnatural amino acids showed a 10‐fold increase in plasma stability although the hydrolysis of Pro12‐Phe13 bond, previously described as a site of cleavage by ACE‐2, was not observed.In vivo, this Pro12‐Phe13 bond was cleaved yet appears as a minor product compared to hydrolysis of the Pro10‐Met11 bond. This study pinpoints the most critical amino acids targeted by proteases and will be instrumental for the design of Pyr1‐apelin‐13 analogs possessing increased stability. © 2014 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 102: 297–303, 2014.
Does a parental history of cancer moderate the associations between impaired health status in parents and psychosocial problems in teenagers: a HUNT study
Authors: Jeppesen Elisabeth , Bjelland Ingvar , Fosså Sophie D. , Loge Jon H. , Sørebø Øystein , Dahl Alv A. 
Published: April 2014

AbstractSevere disease in a parent is associated with increased psychosocial problems in their children. However, moderating factors of such associations are less studied. In this cross‐sectional population‐based controlled study we examined the moderating effects of a history of parental cancer on the association between impaired health status in parents and psychosocial problems among their teenagers. Among families with both parents responding to the adult Health Survey of Nord‐Trøndelag County of Norway (the HUNT‐2 study) 71 couples were identified with primary invasive cancer in one parent. Their 81 teenage children took part in the Young‐HUNT study. These families were compared to 322 cancer‐free families with 328 teenagers. Based on self‐report data the relations between three variables of parental impaired health and six psychosocial problems in teenagers were analyzed family wise by structural equation modeling. Significant associations between parental and teenagers' variables were observed in eight of 18 models. A history of parental cancer was a significant moderator which decreased four of eight significant associations. Such a history significantly weakened the associations between parental poor self‐rated health and teenagers' anxiety/depression and school problems. A similar association of a history of parental cancer was found between psychological distress in parents and teenagers' feelings of loneliness and poor self‐rated health. This study confirmed strong associations between impaired parental health and psychosocial problems in their teenagers. A history of parental cancer weakened several of the significant associations between parental impaired health variables and psychosocial problems in their teenagers.
A Salen–Co3+ Catalyst for the Hydration of Terminal Alkynes and in Tandem Catalysis with Ru–TsDPEN for the One‐Pot Transformation of Alkynes into Chiral Alcohols
Authors: Wang Shoufeng , Miao Chengxia , Wang Wenfang , Lei Ziqiang , Sun Wei 
Published: April 2014

AbstractThe cobalt–salen complex (C1:[(salen)Co3+(OAc)]; salen= N,N′‐bis(salicylidene)ethylenediamine, OAc=acetate) was found to efficiently promote the hydration of terminal alkynes to give methyl ketones in the presence of the H2SO4 cocatalyst. In addition, the one‐pot transformation of alkynes into chiral alcohols through tandem catalysis by catalyst C1 coupled with a ruthenium–TsDPEN complex (C3: [(R,R‐TsDPEN)Ru2+(cymene)]; TsDPEN=(1R,2R)‐N‐(p‐toluenesulfonyl)‐1,2‐diphenylethylenediamine, cymene=1‐methyl‐4‐(1‐methylethyl)benzene) catalyst was realized with excellent yields and enantioselectivities.
Whole‐Cell One‐Pot Biosynthesis of Azelaic Acid
Authors: Otte Konrad B. , Kittelberger Jens , Kirtz Marko , Nestl Bettina M. , Hauer Bernhard 
Published: April 2014

AbstractThe front cover artwork for Issue 04/2014 is provided by the Institute of Technical Biochemistry, University of Stuttgart. The image shows the depiction of an­ Escherichia coli­ whole cell factory, which converts linoleic acid directly into azelaic acid. The three reaction steps are indicated in blue, green, and orange in the zoom‐in.	See the Full Paper itself at http://dx.doi.org/10.1002/cctc.201300787.
Integrating 31P DOSY NMR Spectroscopy and Molecular Mechanics as a Powerful Tool for Unraveling the Chemical Structures of Polyoxomolybdate‐Based Amphiphilic Nanohybrids in Aqueous Solution
Authors: Shestakova Pavletta , Absillis Gregory , Martin‐Martinez Francisco J. , De Proft Frank , Willem Rudolph , Parac‐Vogt Tatjana N. 
Published: April 2014

AbstractNovel organic–inorganic hybrids of various sizes were generated by reaction of 1,8‐octanediphosphonic acid (ODP) and (NH4)6Mo7O24 in aqueous solution. The formation of rodlike hybrids with variable numbers of covalently bound ODP and polyoxomolybdate (POM) units can be tuned as a function of increasing (NH4)6Mo7O24 concentration at fixed ODP concentration. The chemical structure of the ODP/POM hybrids was characterized by 1H, 31P, and 95Mo NMR spectroscopy. Heteronuclear 31P DOSY (diffusion‐ ordered NMR spectroscopy) and molecular mechanics (MM) calculations were applied to determine the size and shape of the nanosized hybrids generated at various ODP/POM ratios. For this purpose, the structures of ODP/POM hybrids with variable numbers of ODP and POM units were optimized by MM and then approximated as cylinder‐shaped objects by using a recently described mathematical algorithm. The thus‐obtained cylinder length and diameter were further used to calculate the expected diffusion coefficients of the ODP/POM hybrids. Comparison of the calculated and experimentally determined diffusion coefficients led to the most probable ODP/POM hybrid length for each sample composition. The 31P DOSY results show that the length of the hybrids increases with increasing POM concentration and reaches a maximum corresponding to an average of 8 ODP/7 POM units per chain at a sample composition of 20 mM ODP and 14 mM POM. With excess POM, above the latter concentration, the formation of shorter‐chain hybrids terminated by Mo7 clusters at one or both ends was evidenced on further increasing the POM concentration. The results demonstrate that the combination of 31P DOSY and MM, although virtually unexplored in POM chemistry, is a powerful innovative strategy for the detailed characterization of nanosized organic–inorganic POM‐based hybrids in solution.
ChemInform Abstract: The Isotypic Hydrogen Phosphate and Arsenate Dihydrates M2HXO4·2H2O (M: Rb, Cs; X: P, As).
Authors: Stoeger Berthold , Weil Matthias 
Published: April 2014

AbstractCs2HAsO4·2H2O, Cs2HPO4·2H2O, Rb2HAsO4·2H2O, and Rb2HPO4·2H2O are precipitated from aqueous H3XO4 (X: As, P) solutions with one equivalent of aqueous M2CO3 (M: Cs,Rb) followed by slow drying.
ChemInform Abstract: Na3[BN2] and Na2K[BN2]: A Known and a Novel Alkali Metal Dinitridoborate Obtained via Mild Thermal Dehydrogenation.
Authors: Koz Cevriye , Acar Selcuk , Prots Yurii , Hoehn Peter , Somer Mehmet 
Published: April 2014

AbstractNa3[BN2] (I) and Na2K[BN2] (II) are obtained from the reaction of the respective binary mixtures NaNH2:NaBH4 and NaNH2:KBH4 in a molar ratio of 2:1 via thermal dehydrogenation (873 K and 683 K, resp., under Ar).
ChemInform Abstract: Synthesis, Structure, and Magnetic Properties of the Novel Sodium Cobalt Tellurate Na5Co15.5Te6O36.
Authors: Shan Yue Jin , Yoshioka Yuta , Wakeshima Makoto , Tezuka Keitaro , Imoto Hideo 
Published: April 2014

AbstractSingle crystals of the new title compound are synthesized by solid state reaction of Na2CO3, Co3O4, and TeO2 (alumina boat, 1273 K, 4 h).
ChemInform Abstract: Ferromagnetic Ordering in the Layer‐Structured Pd(HS2O7)2.
Authors: Bruns Joern , Niehaus Oliver , Poettgen Rainer , Wickleder Mathias S. 
Published: April 2014

AbstractViolet single crystals of Pd(HS2O7)2 are prepared by reaction of elemental Pd and (NO2)OTf in oleum (65% SO3) in a thick‐walled glass ampule (90 °C, 24 h).
ChemInform Abstract: Enantioselective Monofluoromethylation of Aldehydes with 2‐Fluoro‐1,3‐benzodithiole‐1,1,3,3‐tetraoxide Catalyzed by a Bifunctional Cinchona Alkaloid‐Derived Thiourea‐Titanium Complex.
Authors: Ma Hai , Matsuzaki Kohei , Yang Yu‐Dong , Tokunaga Etsuko , Nakane Daisuke , Ozawa Tomohiro , Masuda Hideki , Shibata Norio 
Published: April 2014

AbstractThe first enantioselective monofluorination of aldehydes with the title fluorodithiole (I) is described using a cinchono‐derived thiourea complex as catalyst.
ChemInform Abstract: 3‐Methyl‐4‐oxa‐5‐azahomoadamantane: Alkoxyamine‐Type Organocatalyst for Alcohol Oxidation.
Authors: Sasano Yusuke , Murakami Keiichi , Nishiyama Tomohiro , Kwon Eunsang , Iwabuchi Yoshiharu 
Published: April 2014

AbstractThe title organocatalyst exhibits unexpected high catalytic activity in the presence of NaOCl and KBr to oxidize primary and secondary alcohols to their corresponding carbonyl compounds.
ChemInform Abstract: Chemoselective Hydrogenation Catalyzed by Pd on Spherical Carbon.
Authors: Sajiki Hironao , et al. et al. 
Published: April 2014

AbstractThe reduction of azides, nitro compounds, alkynes, and alkenes is achieved in the presence of benzyl esters, benzyl ethers, nitriles, aromatic ketones, N‐carbobenzyloxy protecting groups, and aromatic O‐TBS ethers using the new heterogeneous palladium catalyst supported on spherical carbon.
ChemInform Abstract: Iodine‐Catalyzed Cycloalkenylation of Dihydroquinolines and Arylamines Through a Reaction with Cyclic Ketones under Neat Conditions.
Authors: Fotie Jean , Ayer Suraj K. , Poudel Binit S. , Reid Carolyn S. 
Published: April 2014

AbstractThe title reaction offers an easy and metal‐free method for the regioselective direct cycloalkenylation of arylamines.
ChemInform Abstract: A Rhodium‐Catalyzed Tandem Alkyne Dimerization/1,4‐Addition Reaction.
Authors: Lerum Ronald V. , Russo Christopher M. , Marquez Jocellie E. , Chisholm John D. 
Published: April 2014

AbstractThe rhodium‐catalyzed tandem alkyne dimerization/1,4‐addition reaction of different alkynes with vinyl ketones is studied.