bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II Trial of Afatinib in Patients With EGFR-Mutated Solid Tumors Excluding Lung Cancer: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol A
Authors: Gettinger Scott N. , Song Zihe , Reckamp Karen L. , Moscow Jeffrey A. , Gray Robert J. , Wang Victoria , McShane Lisa M. , Rubinstein Larry V. , Patton David R. , Williams P. Mickey , Hamilton Stanley R. , Kong Xiao-Tang , Tricoli James V. , Conley Barbara A. , Arteaga Carlos L. , Harris Lyndsay N. , O'Dwyer Peter J. , Chen Alice P. , Flaherty Keith T. 
Published: July 2024

PURPOSE National Cancer Institute–Molecular Analysis for Therapy Choice (NCI-MATCH) was a multicohort phase 2 trial that assigned patients with advanced pretreated cancers to molecularly targeted therapies on the basis of tumor genomic testing. NCI-MATCH Arm A evaluated afatinib, an EGFR tyrosine kinase inhibitor (TKI) approved for advanced non–small cell lung cancer, in patients with tumors other than lung cancer harboring EGFR mutations. METHODS Patients with advanced pretreated cancers other than lung cancer found to have selected actionable EGFR mutations were offered participation in Arm A. Previous therapy with an EGFR TKI was not allowed. Patients received afatinib 40 mg once daily continuously until disease progression or unacceptable toxicity. The primary end point was objective response rate (ORR). Secondary end points included progression-free survival (PFS), 6-month PFS, and overall survival (OS). RESULTS Seventeen patients received protocol therapy. Tumor types included glioblastoma multiforme (GBM) (13), gliosarcoma (1), adenocarcinoma not otherwise specified (NOS) (2), and adenosquamous carcinoma of the breast (1). Fifty-nine percent of patients received ≥2 lines of previous therapy. The ORR was 11.8% (90% CI, 2.1 to 32.6), with one complete response lasting 16.4 months (GBM harboring a rare exon 18 EGFR-SEPT14 fusion) and one partial response lasting 12.8 months (adenocarcinoma NOS with the classic EGFR mutation, p.Glu746_Ala750del). Three patients had stable disease. The 6-month PFS was 15% (90% CI, 0 to 30.7); the median OS was 9 months (90% CI, 4.6 to 14.0). Rash and diarrhea were the most common toxicities. CONCLUSION Afatinib had modest activity in a cohort of patients with heavily pretreated cancer with advanced nonlung, EGFR-mutated tumors, but the trial's primary end point was not met. Further evaluation of afatinib in GBM with EGFR exon 18 fusions may be of interest.
The Effects of the 2021 Child Tax Credit on Housing Affordability and the Living Arrangements of Families With Low Incomes
Authors: Pilkauskas Natasha V. , Michelmore Katherine , Kovski Nicole 
Published: July 2024

Abstract
Access to safe and stable housing is important for child and adult well-being. Yet many low-income households face severe challenges in maintaining stable housing. In this article, we examine the impact of the 2021 temporary expansion to the Child Tax Credit (CTC) on housing affordability and the living arrangements of families with low incomes. We employ a parameterized difference-in-differences method and leverage national data from a sample of parents who are receiving or recently received Supplemental Nutrition Assistance Program benefits (N = ∼20,500), many of whom became newly eligible for the CTC. We find that the monthly CTC reduced parents’ past-due rent/mortgages (both amounts and incidence) and their reports of potential moves due to difficulties affording rent/mortgages. The CTC increased the likelihood that parents reported a change in their living arrangements and reduced their household size, both effects driven by fewer mothers living with a partner (and not a reduction in doubling up). We find some differences in effects by race and ethnicity and earnings. Our findings illustrate that the monthly credit improved low-income parents’ ability to afford housing, gain residential independence from partners, and reduce the number of people residing in their household.
Rejoice architecture meets social norms to accelerate vaccination in Nepal: Protocol for a mixed-method quasi-experimental study
Authors: Paul Alicia , Upreti Kamana , Nepal Shraddha , Lohani Jeevan , Adhikari Kriti , Rimal Rajiv 
Published: July 2024

Background: Each year, 600,000 children under 5 years old die from vaccine-preventable diseases globally. Immunization is an effective way to prevent many diseases, saving two to three million lives per year. The Nepal National Government recommends vaccinations for all children for 11 diseases by 15 months of age. However, only 78% of children between 1-2 years of age have received all recommended vaccines and only 43% receive them at the age-appropriate times for which they are scheduled. Objectives: This protocol describes the development of an intervention – called “Rejoice Architecture” – that is informed by three theoretical perspectives: choice architecture, the broken windows theory, and the theory of normative social behavior. We also describe a mixed-methods approach to develop the intervention, which will improve the physical and social environments of health facilities in Makwanpur, Nepal. We hypothesize this intervention will improve immunization behaviors and intentions among mothers of children younger than 2 years, pregnant women, and prospective mothers. Methods: We describe the qualitative formative assessment to understand existing attitudes, norms, and behaviors among caregivers, healthcare workers, and government representatives. The formative assessment will include in-depth interviews, key informant interviews, and focus group discussions. We also describe the overall quasi-experimental study design, used to assess intervention impact. Impact: This study will contribute to the social and behavioral change communication intervention research by offering a novel strategy for increasing immunization. This study will also illustrate to policymakers the value of structural change for health service delivery.
SARS-CoV-2 and mammals: A short revision
Authors: Corrales-Aguilar Eugenia , Murillo Tatiana 
Published: July 2024

En 2019, se reportó un brote de neumonía de origen desconocido en China, que recordaba al brote por el virus del Severe Acute Respiratory Syndrome (SARS) durante los años 2002-2003. En Febrero de 2020 se identificó al nuevo virus como miembro de la familia Coronaviridae (CoV), nombrado inicialmente como nCOV-19 y asociado con la enfermedad llamada COVID-19. Posteriormente, fue renombrado como SARS-CoV-2 por el comité internacional sobre taxonomía de virus (ICTV por sus siglas en inglés), ya que comparte similitudes con 6 coronavirus humanos conocidos y descritos previamente, incluidos SARS-CoV y MERS-CoV. Los murciélagos, reservorios de muchos coronavirus, fueron los primeros mamíferos implicados en el ciclo de transmisión hacia los humanos. La búsqueda del reservorio natural u hospedero del SARS-CoV-2 se ha centrado en los murciélagos del género Rhinolophus (murciélagos herradura asiáticos). Sin embargo, como ocurre con otros coronavirus, pueden ser necesarios hospederos intermediarios que aún no han sido identificados en la transmisión hacia humanos. El propósito de este trabajo fue realizar una revisión sobre el conocimiento actual de los mamíferos hospederos del SARS-CoV-2 y las manifestaciones clínicas que han presentado. Además, se exploran los reservorios potenciales, y se proponen hospederos intermediarios. Finalmente, se enumeran los desafíos para identificar estas especies claves en el ciclo de transmisión del virus y se aboga por un enfoque de Una Salud para prevenir futuras pandemias.
Dengue and Zika flaviviruses in bats
Authors: Aréchiga-Ceballos Nidia , Rendón-Franco Emilio , Muñoz-García Claudia I. , Olave-Leyva Ignacio , Aguilar-Setién Alvaro 
Published: July 2024

Los murciélagos son reservorios naturales de virus que afectan a los humanos; empero, su papel como reservorios del dengue (DENV) y Zika (ZIKV) es controversial. Su detección molecular y serológica en varias especies sugiere receptividad. Al contrario, otros estudios sugieren que no son receptivos, pues no detectan anticuerpos ni virus. Se examina dicha controversia, analizando estudios de laboratorio y de campo y 4 publicaciones sobre infección experimental de murciélagos Artibeus sp. con DENV y ZIKV. Informes contradictorios sobre la susceptibilidad de las líneas celulares de quirópteros para replicar el DENV pueden deberse al origen filogenéticamente divergente de células utilizadas; en un estudio que reporta producción viral, proceden de murciélagos del Viejo Mundo (Megachiroptera). Estudios en los que no se detecta producción, proceden de murciélagos neotropicales (Yangochiroptera). Los informes serológicos contradictorios pueden deberse a las pruebas utilizadas. La prueba más precisa es la seroneutralización (SNT). Estudios en los que se emplearon la inhibición de la hemaglutinación (HIT) o ensayos de inmunoabsorción ligado a enzimas (ELISA) podrían dar falsos positivos. Así, las 4 infecciones experimentales analizadas en este trabajo utilizaron murciélagos neotropicales (Yangochiroptera) Artibeus sp. y en las 4 se reportó replicación viral ineficiente para ambos flavivirus mediante RT-PCR. Considerando la SNT como un estándar, no se detecta seroconversión; empero, se reportaron alteraciones histopatológicas en murciélagos infectados experimentalmente. Los resultados sugieren que murciélagos del género Aribeus sp., no son amplificadores eficientes del DENV o ZIKA; empero, ambos flavivirus podrían causarles alteraciones. Faltaría estudiar otras especies.
Presence of medium-sized mammals in a fragment of tropical forest on the banks of the Bacalar Lagoon, Quintana Roo
Authors: Sánchez-Zavalegui Romeo Alejandro , Cimé-Ruiz María Marcela , Tuz-Catzin Carlos 
Published: July 2024

Las investigaciones faunísticas desempeñan un papel crucial en los estudios de conservación de la fauna y ecosistemas. En el caso de Bacalar, existe escasez de investigaciones locales sobre la fauna silvestre. El objetivo de esta investigación fue identificar la presencia de mastofauna en un fragmento de selva semiconservada asociada a la Laguna de Bacalar. La investigación se llevó a cabo en el periodo 2022-2023. Se empleó un muestreo sistemático con transectos de 1 km y 2 m de ancho, recorridos diurnos (7:00 hr) y nocturnos (20:00 hr), y la técnica de fototrampeo con 10 cámaras trampa colocadas en zonas estratégicas (senderos de fauna, abrevaderos y periferia de árboles frutales). Se registró la presencia de 12 especies de mamíferos, pertenecientes a 6 órdenes y 9 familias, destacando el orden Carnivora con 4 especies. Se obtuvo un segundo registró de Potos flavus (martucha) en Bacalar, y Herpailurus yagouaroundi (jaguarundi) y Leopardus wiedii (tigrillo) escasamente citados en la zona. Durante la temporada de secas (mayo-agosto), se observaron 8 de las 12 especies reportadas. La riqueza de depredadores del orden Carnivora se atribuye al buen estado de conservación del área de estudio y la presencia de presas. Además, el aumento de registros durante la temporada de secas puede relacionarse con la Laguna de Bacalar como fuente de abrevadero. Se destaca la importancia de los estudios locales de fauna y la necesidad de efectuar mayores estudios de la mastofauna del estado de Quintana Roo.
Patterns of inpatient acute care and emergency department utilization within one year post-initial amputation among individuals with dysvascular major lower extremity amputation in Ontario, Canada: A population-based retrospective cohort study
Authors: Guilcher Sara J. T. , Mayo Amanda L. , Swayze Sarah , de Mestral Charles , Viana Ricardo , Payne Michael W. , Dilkas Steven , Devlin Michael , MacKay Crystal , Kayssi Ahmed , Hitzig Sander L. 
Published: July 2024

Introduction
Lower extremity amputation (LEA) is a life altering procedure, with significant negative impacts to patients, care partners, and the overall health system. There are gaps in knowledge with respect to patterns of healthcare utilization following LEA due to dysvascular etiology.

Objective
To examine inpatient acute and emergency department (ED) healthcare utilization among an incident cohort of individuals with major dysvascular LEA 1 year post-initial amputation; and to identify factors associated with acute care readmissions and ED visits.

Design
Retrospective cohort study using population-level administrative data.

Setting
Ontario, Canada.

Population
Adults individuals (18 years or older) with a major dysvascular LEA between April 1, 2004 and March 31, 2018.

Interventions
Not applicable.

Main outcome measures
Acute care hospitalizations and ED visits within one year post-initial discharge.

Results
A total of 10,905 individuals with major dysvascular LEA were identified (67.7% male). There were 14,363 acute hospitalizations and 19,660 ED visits within one year post-discharge from initial amputation acute stay. The highest common risk factors across all the models included age of 65 years or older (versus less than 65 years), high comorbidity (versus low), and low and moderate continuity of care (versus high). Sex differences were identified for risk factors for hospitalizations, with differences in the types of comorbidities increasing risk and geographical setting.

Conclusion
Persons with LEA were generally more at risk for acute hospitalizations and ED visits if higher comorbidity and lower continuity of care. Clinical care efforts might focus on improving transitions from the acute setting such as coordinated and integrated care for sub-populations with LEA who are more at risk.
Evaluation of a national program to distribute free face masks in Uganda: Evidence from Mbale District
Authors: Jakubowski Aleksandra , Egger Dennis , Mulebeke Ronald , Akankwasa Pius , Muruta Allan , Kiwanuka Noah , Wanyenze Rhoda K. 
Published: July 2024

Background
COVID-19 posed a major threat to countries around the world, but many nations in sub-Saharan Africa avoided large-scale outbreaks. In Uganda, the government first enacted strict lockdowns but later focused on public health policies like masking and distancing. The government also embarked on an ambitious campaign to deliver a free face mask to all Ugandan citizens (approx. 30 million masks). We test whether mask distribution, and public education and encouragement of mask use by community health volunteers, affected mask behavior.

Methods
We collected data about mask behavior before and after masks were distributed in the Mbale district of Uganda. Trained enumerators directly observed mask wearing in public places and asked about mask use via phone surveys. We compared observed and self-reported mask behavior before and after masks were distributed. We also tested whether training volunteers from randomly selected villages to educate the public about COVID-19 and masks affected behavior, attitudes, and knowledge among mask recipients.

Results
We collected 6,381 direct observations of mask use at baseline (February 2021) and 19,855 observations at endline (April 2021). We conducted a listing of 9,410 households eligible for phone surveys and randomly selected 399 individuals (4.2%) at baseline and 640 (6.8%) at endline. Fewer than 1% of individuals were observed wearing masks at baseline: 0.9% were seen with a mask and 0.5% wore masks over mouth and nose. Mask wearing significantly increased at endline but remained low: 1.8% of people were observed with masks and 1.1% were seen wearing masks correctly after the distribution campaign. At the same time, a high proportion of people reported using masks: 63.0% of people reported using masks at baseline and 65.3% at endline when walking around their villages. When respondents were asked about mask use in public places, 94.7% reported using masks at baseline and 97.4% reported using masks at endline. We found no differences in knowledge, behavior, or attitudes among mask recipients in villages where volunteers were tasked with conveying information about COVID-19 and masks during distribution.

Conclusion
Mask use remained low in Mbale district of Uganda during study observation period even after free masks were distributed. Encouraging new health behaviors may need to involve more intensive interventions that include reminders and address social norms.
Pooled prevalence, spatial variation and associated factors of HIV testing uptake among multiple sexual partners in Sub Saharan Africa: Spatial and multilevel analysis
Authors: Lealem Emebet Birhanu , Zeleke Ejigu Gebeye , Andargie Betelhem Abebe , Wagnew Alemakef 
Published: July 2024

Background
Uptake of HIV testing is vital for the early diagnosis of HIV infection and initiation of treatment, which are used to eliminate the disease’s progression and reduce HIV-related mortality. Even if determining HIV testing is imperative to prevent HIV/AIDS among multiple sexual partners who are at higher risk of sexually transmitted infections, most of the countries in Sub Saharan Africa did not fulfil the global targets of UNAIDS. Moreover there is a paucity of literature on spatial variation and factors associated with HIV testing among high-risk groups in SSA. This study aimed to assess the pooled prevalence, spatial variation and determinants of HIV testing uptake among multiple sexual partners in Sub Saharan Africa.

Methods
The Demographic and Health Surveys data conducted between 2011 and 2021 in 30 Sub-Saharan Africa countries was used to analyze total weighted sample of 56,210 multiple sexual partners. Exploratory spatial data analysis, with countries as the unit of analysis was conducted using ArcGIS V10.7.1 and Sat Scan V 10.1 soft wares. A multilevel binary logistic regression model was used to identify the factors associated with the HIV testing uptake. The Adjusted odds Ratio with a 95% confidence interval was reported to declare the strength of association and their statistical significance.

Results
The spatial patterns of HIV testing uptake were found to be non-random. Primary clusters were identified around western and central sub- regions. Multiple sexual partners who were ever married, those attended primary level and above education, those from rich wealth status, aged above 24 years, having good HIV related knowledge, and exposed to media were positive association with HIV testing uptake. However, being male, having working status and living in rural area were negatively associated with HIV testing uptake. At the community-level, multiple sexual partners from communities in Eastern and southern sub regions, countries with upper middle income and countries with the survey year after 2014 were more likely to utilize HIV testing services compared with their counterparts.

Conclusion
In this study, the pooled prevalence of the HIV testing uptake among multiple sexual partners was found to be lower than the universal target and showed differences in HIV testing uptake across Sub-Saharan Africa region. Both individual and community-level factors affected HIV testing uptake among multiple sexual partners. Stakeholders should implement interventions to help increase the uptake of HIV testing among those risky groups in this region.
STRATEGY AND PARTICIPATION OF COFFEE AGRO-TOURISM DEVELOPMENT IN WAGIR DISTRICT, MALANG REGENCY
Authors: Risvita Wuwun , Parmawati Rita , Mulyadi Fadli , Mamilianti Wenny 
Published: July 2024

The coffee commodity and supported by a unique landscape on Mount Kawi's slopes, is an excellent potential for Wagir District to develop into a coffee agrotourism destination. This development cannot be separated from the cooperation needed from the government to the community, especially farmers so that this Coffee Agrotourism can have a welfare and sustainability impact on society and the environment. Also, this study aims to describe the condition of coffee plantations and the level of community participation in their management and to analyze the company's internal and external factors that can formulate appropriate development strategies. Mixed methods were used in this research, and analytical tools such as AHP-SWOT and the Arnstein Participation Ladder Analysis were used. The study results showed that community participation in developing coffee agro-tourism is still relatively low. It is triggered by limited understanding and knowledge regarding the concept of agro-tourism. Recommendations for development strategies are based on the level of participation and conditions in the field, namely by increasing field extension resources to increase farmer institutions' role in creating good coffee agro-tourism. Good farmer institutions are expected to maintain coffee quality and uniformity of coffee quality through farmer groups and improve marketing efficiency.
Działania prokuratury po wniesieniu zażalenia na postanowienia zamykające drogę do wydania wyroku
Authors: Karlik Piotr 
Published: July 2024

Opracowanie dotyczy oceny działania prokuratury po wniesieniu przez pokrzywdzonego zażalenia na postanowienie o odmowie wszczęcia lub umorzenia postępowania. Jak pokazuje obecna praktyka, spotykamy tutaj specyficzne zachowanie organu, które w konsekwencji może prowadzić do istotnego naruszenia uprawnień procesowych pokrzywdzonego. Przedmiotem publikacji jest krytyczna ocena takiego działania oparta na gruntownej analizie przepisów regulujących funkcjonowanie postępowania w tym właśnie zakresie. Wniesienie środka odwoławczego, czyli poddanie decyzji procesowej kontroli odwoławczej, powinno petryfikować postępowanie dowodowe i wyłączać jakąkolwiek aktywność procesową, bez uprzedniej decyzji o podjęciu postępowania na skutek uwzględnienia zażalenia. W przeciwnym wypadku zostaje podważony sens sądowej kontroli, a w konsekwencji prawo do sądu zostaje istotnie ograniczone. Poniższe rozważania mają na celu wskazanie problemu istniejącego w praktyce i zwrócenie uwagi na negatywne konsekwencje z niej wynikające. Jak bowiem wynika z prezentowanych analiz, nie ulega wątpliwości, że obecna sytuacja musi ulec zmianie.
Satysfakcja z miejsca zamieszkania: analiza porównawcza państw Unii Europejskiej
Authors: Sadko Maria 
Published: July 2024

Przedmiotem artykułu jest poziom satysfakcji z miejsca zamieszkania wśród mieszkańców państw Unii Europejskiej. Celem badania jest porównanie odczuwanego przez mieszkańców tych państw zadowolenia związanego z ich miejscem zamieszkania, podzielenie państw UE na jednorodne grupy ze względu na wcześniej wspomnianą satysfakcję, jak również ocena, czy modele polityki mieszkaniowej i społecznej realizowane w danych państwach są zbieżne z wynikami grupowania, oraz określenie, czy w powstałych grupach występuje zjawisko deprywacji mieszkaniowej. Dane zaczerpnięto z dwóch źródeł: Europejskiego Badania Jakości Życia (EQLS) 2016, które zawiera m.in. zmienne odzwierciedlające subiektywne poczucie satysfakcji z miejsca zamieszkania respondentów, oraz bazy danych Eurostat, zawierającej m.in. informacje na temat deprywacji mieszkaniowej. Analiza pokazała, że optymalnym rozwiązaniem jest podział państw na pięć grup. W powstałych grupach przeanalizowano, w jakim stopniu mieszkańcy odczuwają satysfakcję z miejsca zamieszkania, dzięki temu wskazano zbiory mieszkańców najbardziej oraz najmniej zadowolonych z miejsca swojego zamieszkania. Ponadto wykazano, że istnieje zauważalny związek między modelem polityki mieszkaniowej stosowanym w danym państwie a wynikami grupowania, natomiast w przypadku modeli polityki społecznej nie zauważono analogicznych powiązań. Dodatkowo wskazano, które elementy deprywacji mieszkaniowej występowały najczęściej, a które najrzadziej w wyznaczonych grupach państw. Problemami, które dotykają znaczną część gospodarstw domowych we wszystkich wyznaczonych grupach, są nadmierna wilgotność, hałas z ulicy lub od sąsiadów, zanieczyszczenie oraz przestępczość w okolicy miejsca zamieszkania. Artykuł wnosi wkład do literatury na temat jakości zamieszkania, która jest jednym z istotnych aspektów jakości życia. Pokazuje, które państwa są podobne ze względu na odczuwaną przez mieszkańców satysfakcję z miejsca zamieszkania oraz od czego to podobieństwo może zależeć.