bluuebunny/crossref_metadata_2025_split huggingface dataset:
A HIF-1 network reveals characteristics of epithelial-mesenchymal transition in acute promyelocytic leukemia
Authors: Percio Stefano , Coltella Nadia , Grisanti Sara , Bernardi Rosa , Pattini Linda 
Published: December 2014

Abstract
Background
Acute promyelocytic leukemia (APL) is a sub-type of acute myeloid leukemia (AML) characterized by a block of myeloid differentiation at the promyelocytic stage and the predominant t(15:17) chromosomal translocation. We have previously determined that cells from APL patients show increased expression of genes regulated by hypoxia-inducible transcription factors (HIFs) compared to normal promyelocytes. HIFs regulate crucial aspects of solid tumor progression and are currently being implicated in leukemogenesis.

Methods
To investigate the contribution of hypoxia-related signaling in APL compared to other AML sub-types, we reverse engineered a transcriptional network from gene expression profiles of AML patients’ samples, starting from a list of direct target genes of HIF-1. A HIF-1-dependent subnetwork of genes specifically dysregulated in APL was derived from the comparison between APL and other AMLs.

Results
Interestingly, this subnetwork shows a unique involvement of genes related to extracellular matrix interaction and cell migration, with decreased expression of genes involved in cell adhesion and increased expression of genes implicated in motility and invasion, thus unveiling the presence of characteristics of epithelial-mesenchymal transition (EMT). We observed that the genes of this subnetwork, whose dysregulation shows a peculiar pattern across different AML sub-types, distinguish malignant from normal promyelocytes, thus ruling out dependence on a myeloid developmental stage. Also, expression of these genes is reversed upon treatment of APL-derived NB4 cells with all-trans retinoic acid and cell differentiation.

Conclusions
Our data suggest that pathways related to EMT-like processes can be implicated also in hematological malignancies besides solid tumors, and can identify specific AML sub-types.
Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis
Authors: Dixit Neha , Wu Dennis J , Belgacem Yesser H , Borodinsky Laura N , Gershwin M Eric , Adamopoulos Iannis E 
Published: December 2014

Abstract
Introduction
Bone erosion in inflammatory arthritis depends on the recruitment and activation of bone resorbing cells, the osteoclasts. Interleukin-23 (IL-23) has been primarily implicated in mediating inflammatory bone loss via the differentiation of Th17 receptor activator of nuclear factor κB ligand (RANKL)–producing cells. In this article, we describe a new role of IL-23 in activating the synthesis and production of leukotriene B4 (LTB4) in innate immune cells.

Methods
We utilized whole blood–derived human peripheral blood mononuclear cells (PBMCs), differentiated them towards an osteoclast lineage and then performed immunofluorescence and cytochemical staining to detect the expression of LTB4-associated receptors and enzymes such as phospholipase A2, 5-lipoxygenase and leukotriene A4 hydrolase, as well as the presence of tartrate-resistant acid phosphatase (TRAP) and F-actin rings on fully mature osteoclasts. We used enzyme immunoassays to measure LTB4 levels in culture media derived from IL-23-treated human PBMCs. We used real-time calcium imaging to study the effect of leukotrienes and requirements of different calcium sources and signaling proteins in activating intracellular calcium flux using pharmacological inhibitors to phospholipase C (U73122), membrane calcium channels (2-APB) and phosphatidylinositol 3-kinase (Wortmannin) and utilized qPCR for gene expression analysis in macrophages and osteoclasts.

Results
Our data show that LTB4 engagement of BLT1 and BLT2 receptors on osteoclast precursors leads to activation of phospholipase C and calcium release–activated channel–mediated intracellular calcium flux, which can activate further LTB4 autocrine production. IL-23-induced synthesis and secretion of LTB4 resulted in the upregulation of osteoclast-related genes NFATC1, MMP9, ACP5, CTSK and ITGB3 and the formation of giant, multinucleated TRAP+ cells capable of F-actin ring formation. These effects were dependent on Ca2+ signaling and were completely inhibited by BLT1/BLT2 and/or PLC and CRAC inhibitors.

Conclusions
In conclusion, IL-23 can initiate osteoclast differentiation independently from the RANK-RANKL pathway by utilizing Ca2+ signaling and the LTB4 signaling cascade.
Shifting paradigms for fashion: from total to global to smart consumer experience
Authors: Kim HaeJung , Ahn Soo-Kyoung , Forney Judith A 
Published: December 2014

AbstractEmergence of a global techno-economic system is challenging academia and the fashion industry. Consumers, the retail industry and business strategies are strategically contributing to the changing fashion paradigm, which is shifting from the Total (TCE), to Global (GCE) and to Smart Consumer Experience (SCE) concepts. The consumer experience is a pervasive value orientation that is transforming how consumers think, gain information, and make decisions about consumption activities to maximize their total experience value. Moreover, the experiences, products and services that consumers seek are being defined with a global and smart perspective that is made possible by boundary-free access to information and sourcing of products and services. Specifically, the smart consumer experience advocates consumer participation by leveraging the power of communities and networks and enabling consumers to influence retail businesses and co-create future marketspace values. This phenomenon has implications for fashion consumers and fashion retail industry business strategies since fashion is an emulated behavior.
Fabrication and heat treatment of ceramic-reinforced aluminium matrix composites - a review
Authors: Das Dipti Kanta , Mishra Purna Chandra , Singh Saranjit , Pattanaik Swati 
Published: December 2014

Abstract
Ceramic-reinforced aluminium matrix composites have attracted considerable attention in engineering applications as a result of their relatively low costs and characteristic isotropic properties. Reinforcement materials include carbides, nitrides and oxides. In an effort to achieve optimality in structure and properties of ceramic-reinforced metal matrix composites (MMCs), various fabrication and heat treatment techniques have evolved over the last 20 years. In this paper, the status of the research and development in fabrication and heat treatment techniques of ceramic-reinforced aluminium matrix composites is reviewed, with a major focus on material systems in terms of chemical compositions, weight or volume fraction, particle size of reinforcement, fabrication methods and heat treatment procedures. Various optical measurement techniques used by the researchers are highlighted. Also, limitations and needs of the technique in composite fabrication are presented in the literature. The full potential of various methods for fabricating ceramic-reinforced aluminium matrix composites is yet to be explored.
Idols of Development
Authors: Käng Dredge Byung'chu 
Published: December 2014

Abstract
Inter-Asian cultural flows are transforming everyday Thai gender practices and performances in unexpected ways. The most striking example is the way in which Korean popular music, or K-pop, is molding contemporary beauty and dance aesthetics through cover dance, the copying of choreographed movements from music videos. K-pop cover dance has become a definitive social activity among Asian sissies (young feminine gay men) and is organized into an extensive contest circuit leading to an annual competition in Korea. Thai sissies are among the most enthusiastic and skillful practitioners of K-pop cover dance, and some practitioners, such as the members of the group Wonder Gay, have become national celebrities. I describe how cover dance demarcates a new social arena for feminine Thai males to express themselves through the idiom of modern Korean female embodiment. Semiprofessional cover dancers constitute a class of “hyper-fans” who become “demi-idols,” with fan followings in their own right. I argue that Thai K-pop cover dance can be read as both an aspiration for personal and national development that indexes participation in a new cosmopolitan Asian sphere. The cover dance phenomenon in Thailand highlights recent shifts in Asian regionalism, idol fandom, and transgressive gender performance.
Patient-reported outcome and quality of life after total en bloc spondylectomy for a primary spinal tumour
Authors: Kato S. , Murakami H. , Demura S. , Yoshioka K. , Kawahara N. , Tomita K. , Tsuchiya H. 
Published: December 2014

Total en bloc spondylectomy (TES) is the total resection of a vertebra containing a tumour. Many authors have investigated patient-reported outcomes after routine spinal surgery and surgery for tumours in general. However, this is the first report of patient-reported outcomes, including health-related quality of life (HRQoL) and satisfaction, after en bloc vertebral resection for a spinal tumour. Of the 54 patients who underwent TES for a primary tumour between 1993 and 2010, 19 died and four were lost to follow-up. In January 2012, a questionnaire was sent to the 31 surviving patients. This included the short form-36 to assess HRQoL and questions about the current condition of their disease, activities of daily living (ADL) and surgery. The response rate was high at 83.9% (26/31 patients). We found that most patients were satisfied and maintained good performance of their ADLs. The mental health status and social roles of the HRQoL scores were nearly equivalent to those of healthy individuals, regardless of the time since surgery. There was significant impairment of physical health in the early post-operative years, but this usually returned to normal approximately three years after surgery. Cite this article: Bone Joint J 2014;96-B:1693–8.
Stigma: Barriers to Culture and Identity for People With Intellectual Disability
Authors: Spassiani Natasha A. , Friedman Carli 
Published: December 2014

Abstract
This exploratory article examines disability culture and identity for people with intellectual disability. In doing so, we argue that the stigma around intellectual disability severely affects people with intellectual disability's sense of culture and identity. This stigma causes internalized ableism and leads to people with intellectual disability disassociating from other people with intellectual disability in an attempt to cope with this stigma. True community inclusion for people with intellectual disability can only occur when this stigma is removed. Fortunately, as we argue, the self-advocacy movement is making great strides in doing so. The self-advocacy movement must be supported to achieve true inclusion and a sense of culture and identity for people with intellectual disability.
T-Cell Prolymphocytic Leukemia with Extensive Cardiovascular Infiltrate Leading to Multiple Myocardial Infarctions and Cardiac Death
Authors: Cheng Hong , Feldman Tatyana , Butt Yasmeen , Chow Kar F. , Yang Xiao Yan , Bhattacharyya Pritish K. , de Vinck David C. 
Published: December 2014

Lymphocytic neoplasm involving the heart is not common and usually presents with pericardial effusion or focal myocardial infiltration. Myocardial infarctions due to leukemic infiltration of the coronary arteries are rarely reported. We present the case of a 52-year-old Guatemalan man with a one-year history of untreated T-cell prolymphocytic leukemia. He was admitted to our hospital for chemotherapy and evaluation of a pulmonary cavitary lesion by wedge resection. During sedation, the patient experienced acute respiratory failure and hypovolemic shock, from which he could not be resuscitated.
Autopsy revealed that leukemic cells extensively infiltrated the aorta, myocardium, and coronary arteries. The lumina of the 3 major coronary artery branches showed 70% to 95% stenosis, with multifocal remote myocardial infarctions. Tumor cells were also detected in the lungs and other organs. The acute cardiorespiratory insufficiency secondary to leukemia—particularly the extensive infiltration of the coronary arteries and myocardium, and the multiple myocardial infarctions—eventually resulted in cardiac death.
Concurrent Aortic Valvular Disease and Pulmonary Sequestration: Clinical Implications
Authors: Hui Dawn S. , Shavelle David M. , Starnes Vaughn A. , McFadden P. Michael 
Published: December 2014

Pulmonary sequestration refers to segmental lung tissue that has no connection with the bronchial tree or pulmonary arteries. In adults, the clinical sequelae are usually related to infection. Patients are typically referred for sequestrectomy even when they are asymptomatic. There are no guidelines for treating patients who have pulmonary sequestration and coexisting cardiac valvular disease, in which case the venous drainage patterns of sequestra pose the additional risks of infective endocarditis and volume overload.
We present the cases of 2 adult patients—one symptomatic and one asymptomatic—who had concurrent aortic valvular disease and pulmonary sequestration, and we discuss the factors involved in our evaluation of their cardiac risk and our treatment decisions. In view of the sparse data to predict cardiac risks, we think that pulmonary sequestrectomy in adult patients with concurrent valvular conditions should be considered on a case-by-case basis.
Repeated Transradial Catheterization: Feasibility, Efficacy, and Safety
Authors: Charalambous Marinos A. , Constantinides Savvas S. , Talias Michael A. , Soteriades Elpidoforos S. , Christou Christos P. 
Published: December 2014

Transradial access is an alternative to the transfemoral approach in coronary interventions. It results in less access-site bleeding, shorter hospital stays, lower costs, and less pain for the patient. However, some authors have suggested that the transradial approach might lead to radial artery occlusion, which precludes repeated same-artery catheterizations. Using data from our center, we evaluated the feasibility, safety, and efficacy of repeated transradial catheterization.
We reviewed the 3,006 transradial catheterizations performed at our center from 2006 through 2009. Patients who had undergone at least one repeated transradial catheterization were identified, their cases monitored through 2012, and their baseline characteristics and other factors, including procedural sequelae, were analyzed.
Seventy-nine patients underwent repeated right radial artery catheterizations, for a total of 92 repeated procedures. Repeated access to the right radial artery was not achieved in 4 attempts (failure rate, 4.3%), because of poor pulses or the operator's inability to advance the wire. No major sequelae were noted. The average times between the 1st to 2nd, 2nd to 3rd, and 3rd to 4th catheterizations were 406, 595, and 401 days, respectively.
Our procedural success rate of 95.7% in performing repeated transradial catheterizations with no major sequelae provides support for the efficacy and safety of such procedures.
Abnormal driving forces induced by curvatures and gradients of curvatures on micro/nano curved surfaces
Authors: Yin Yajun , Wu Jiye 
Published: December 2014

AbstractThis paper elaborates that at micro/nanoscales, highly curved matter spaces may induce abnormal driving forces. Such abnormal driving forces are controlled by two fundamental factors: one is the bending extent of surfaces (curvature) and another is the non-uniform extent of bending surfaces (the gradients of curvatures).
Wave propagation in an initially stressed transversely isotropic thermoelastic half-space
Authors: Gupta Raj Rani , Saroa M.S. 
Published: December 2014

AbstractThe present paper deals with the study of reflection waves in an initially stressed transversely isotropic medium, in the context of Green and Naghdi (GN) thermoelasticity theory type II and III. The components of displacement, stresses and temperature distributions are determined through the solution of the wave equation by imposing the appropriate boundary conditions. Numerically simulated results are plotted graphically with respect to frequency in order to show the effect of anisotropy.
Disease-free Pre-Basic Seed Potato Production through Tissue Culture in Nepal
Authors: Sakha Binesh M. , Rai Gyan P. , Dhital Shambhu P. , Nepal Ram B. 
Published: December 2014

Pre-basic seed potatoes are disease free potato minitubers produced by transplanting pathogen free in vitro potato plantlets under protected condition in aphid-proof glasshouse and/or screen house. Double antibody sand witched - enzyme linked immuno-sorbant assay is used to test six major potato viruses, namely PLRV, PVS, PVX, PVY, PVA and PVM. Thermotherapy cum meristem tip excision techniques are used to eliminate these viruses. Virus free in vitro potato plantlets are rapidly propagated by single nodal cuttings on modified MS media. For pre-basic seed production disease free in vitro potato plantlets are transplanted in the sterile sand soil substrate under glasshouse and screen house, once in autumn season and next in spring season. Since 1990, National Potato Research Program has been producing about 200,000 pre-basic seeds annually. So far, PBS of 19 different recommended and released potato cultivars has been produced. Till date 3,465,799 PBS had been produced and 3,217,666 pre-basic seeds distributed to the different seed potato growers groups, District Agriculture Development Offices, government farms/research stations, and NGOs/INGOs for subsequent basic seed potato production. After establishment of tissue culture facilities in National Potato Research Program, the productivity of potato has been increased by 71% due to utilization of pre-basic seed potatoes.Nepal Agric. Res. J. Vol. 8, 2007, pp. 7-13DOI: http://dx.doi.org/10.3126/narj.v8i0.11564
Evaluation of Open Pollinated Normal Maize Varieties in the Eastern Mid Hill of Nepal
Authors: Sah Surya N. , Sharma Diwakar 
Published: December 2014

Full season maize genotypes were evaluated in on station coordinated varietal experiments during summer season at Agriculture Research Station (ARS), Pakhribas in three consecutive years 2003, 2004 and 2005. The experiments were laid out in randomized complete block design (RCBD) with three replications. The objective of this study was to identify high yield potential normal maize genotypes suitable for the existing cropping patterns in the eastern mid hill. Genotypes were evaluated in coordinated varietal trials (CVT) in 2003, 2004 and 2005 and in intermediate yield trial (IYT) in 2004. Five common genotypes including local and standard check were evaluated in the CVT 2003 and in the CVT 2004, another five common genotypes tested in the CVT 2004 and in the CVT 2005 and six common genotypes of the IYT 2004 and CVT 2005 were analyzed over year. Genotype P501-SARCO-F1/P502-SARCO-F1 produced significantly higher grain yield followed by DRACOSYN- F1/DRBCOSYN-F1 in the 1st two years and found about one week earlier than Mankamana-3. Across 00502 and Across 9942/Across 9944 were found superior with respect to grain yield and phenotypic characters like husk cover, plant aspect and ear aspect both in CVT 2005 and IYT 2004 across the years and the genotype Across 9942/Across 9944 was found tolerant to turcicum leaf blight (TLB) in 2005.Nepal Agric. Res. J. Vol. 8, 2007, pp. 18-22DOI: http://dx.doi.org/10.3126/narj.v8i0.11566
Integrated Disease Management of Tomato Late Blight
Authors: Shrestha Krishna K. , Ashley Richard 
Published: December 2014

Tomato late blight caused by Phytophthora infestans (Mont.) de Bary is a serious disease of tomato and potato worldwide. The disease causes severe crop losses in the tomato growing regions of the world. Most of the cultivars grown in the world are reported to be susceptible to late blight. Systemic fungicides have been used widely in the past, but the disease has developed resistance over time. The present study was carried out to minimize fungicide use through integrated pest management. The bio-pesticides Azadirachta indica (Neem), Artemisia vulgaris (Mugwort) and Trichoderma viride were tested along with the fungicides Krilaxyl (metalaxyl 8% and mancozeb 64%) and Dithane M-45 (mancozeb 80%) in Nepal during 2000 and 2001. All three bio-pesticides were found more effective than the control in reducing development of the disease and they increased yield over the control by 17 to 41%. However, the fungicides, Krilaxyl and Dithane M-45 were observed even more effective. Two transplanting dates ie first and third week of July were tested against late blight in rainy season during 2000and 2001 and observed its effect on yields. Lower disease incidence and better yield were found in the second planting. Nepal Agric. Res. J. Vol. 8, 2007, pp. 67-76DOI: http://dx.doi.org/10.3126/narj.v8i0.11583
Marketing Constraints to Goats in the Western Hill of Nepal
Authors: Nepali Megh B. , Tiwari Megh R. , Sapkota Sudha , Poudel Hari P. , Acharya Budhi R. , Gautam Sudeep 
Published: December 2014

Goat marketing study was conducted in eleven districts with the objectives of exploration the existing goat marketing system in western hills of Nepal. The methodology of the study was households survey, Rapid Marketing Appraisal and use of secondary data. Some of the marketing centers are at the village level, catchments, terminal level markets and district headquarters. There are some marketing agents dealing with the goat marketing from village to the municipalities. Goat marketing agents mainly found farmers and middlemen at the village level and catchments markets. In terminal markets mainly wholesalers and middlemen were involved where as in district headquarters and municipalities middlemen, wholesalers and butchers were dealing the goat business. 59.3% respondents believed that middlemen visit in the village for goat marketing. Almost all farmers sell their goats on the basis of estimated price. Major constraints on goat marketing were lack of public goat marketing centres, lack of communications about goat marketing and lack of infrastructure etc in all the domestic markets. In the western hills of Nepal main goat marketing centre was found in Pokhara sub municipality where traders/whole sellers bring their goats to sale from different catchments. Government has the provision of establishing new goat marketing centers in each VDCs and district headquarters.Nepal Agric. Res. J. Vol. 8, 2007, pp. 95-102DOI: http://dx.doi.org/10.3126/narj.v8i0.11601