bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal modeling of cognitive aging and the TOMM40 effect
Authors: Caselli Richard J. , Dueck Amylou C. , Huentelman Matthew J. , Lutz Michael W. , Saunders Ann M. , Reiman Eric M. , Roses Allen D. 
Published: October 2012

AbstractBackgroundTOMM40 (translocase of the outer mitochondrial membrane pore subunit) is in linkage disequilibrium with apolipoprotein E (APOE). APOE e4 is linked to long (L; 21–29 T residues) poly‐T variants within intron 6 of TOMM40, whereas APOE e3 can be associated with either a short (S; <21 T residues) or very long (VL; >29 T residues) variant. To assess the possible contribution of TOMM40 to Alzheimer's disease onset, we compared the effects of TOMM40 and APOE genotype on preclinical longitudinal memory decline.MethodsAn APOE e4–enriched cohort of 639 cognitively normal individuals aged 21 to 97 years with known TOMM40 genotype underwent longitudinal neuropsychological testing every 2 years. We estimated the longitudinal effect of age on memory using statistical models that simultaneously modeled cross‐sectional and longitudinal effects of age on the Auditory Verbal Learning Test Long‐Term Memory score by APOE, TOMM40, and the interaction between the two.ResultsThere were significant effects overall for both TOMM40 (linear effect, P = .04; quadratic effect, P = .03) and APOE (linear effect, P = .06; quadratic effect, P = .008), with no significant interaction (P = .63). In a piecewise model, there was a significant TOMM40 effect before age 60 years (P = .009), characterized by flattened test–retest improvement (VL/VL subgroup only) but no significant APOE effect, and a significant APOE effect after age 60 years (P = .006), characterized by accelerated memory decline (e4 carriers) but no significant TOMM40 effect.ConclusionBoth TOMM40 and APOE significantly influence age‐related memory performance, but they appear to do so independently of each other.
Computer‐related self‐efficacy and anxiety in older adults with and without mild cognitive impairment
Authors: Wild Katherine V. , Mattek Nora C. , Maxwell Shoshana A. , Dodge Hiroko H. , Jimison Holly B. , Kaye Jeffrey A. 
Published: October 2012

AbstractThis study examines differences in computer‐related self‐efficacy and anxiety in subgroups of older adults, and changes in those measures after exposure to a systematic training program and subsequent computer use.MethodsParticipants were volunteers in the Intelligent Systems for Assessment of Aging Changes study (ISAAC) carried out by the Oregon Center for Aging and Technology. Participants were administered two questionnaires before training and again 1 year later, which were related to computer self‐efficacy and anxiety. Continuous recording of computer use was also assessed for a subset of participants.ResultsBaseline comparisons by sex, age, education, living arrangement, and computer proficiency, but not cognitive status, yielded significant differences in confidence and anxiety related to specific aspects of computer use. At 1‐year follow‐up, participants reported less anxiety and greater confidence. However, the benefits of training and exposure varied by group and task. Comparisons based on cognitive status showed that the cognitively intact participants benefited more from training and/or experience with computers than did participants with mild cognitive impairment (MCI), who after 1 year continued to report less confidence and more anxiety regarding certain aspects of computer use.ConclusionAfter 1 year of consistent computer use, cognitively intact participants in this study reported reduced levels of anxiety and increased self‐confidence in their ability to perform specific computer tasks. Participants with MCI at baseline were less likely to demonstrate increased efficacy or confidence than their cognitively intact counterparts.
Effectiveness of antidementia drugs in delaying Alzheimer's disease progression
Authors: Rountree Susan D. , Atri Alireza , Lopez Oscar L. , Doody Rachelle S. 
Published: October 2012

AbstractBackgroundRandomized controlled trials (RCTs) provide safety and efficacy data for regulatory approval of antidementia drugs, but offer limited data regarding real‐world effectiveness. Long‐term observational controlled studies (LTOCs) extend our understanding by providing longitudinal data across multiple stages of Alzheimer's disease (AD).MethodsComparisons of strengths, limitations, evidence level, and results for monotherapy (cholinesterase inhibitors) and combination therapy (cholinesterase inhibitors + memantine) in RCTs versus LTOCs were made.ResultsSimilar to RCTs, LTOCs have shown that both monotherapy and combination therapy are associated with slower cognitive and functional decline. Combination therapy is associated with better cognitive outcomes and greater delays in time to nursing home admission versus monotherapy or no treatment. Persistent antidementia drug treatment is associated with slower decline in cognition, daily function, and global severity, even in patients with advanced disease.ConclusionsLTOCs provide complementary evidence regarding effectiveness of antidementia therapy over many years, a time course relevant to AD management. These findings also provide compelling arguments in favor of using LTOCs to estimate effectiveness, risk–benefit, and costs of AD treatments.
Whole‐Body Vibration During Passive Standing in Individuals With Spinal Cord Injury: Effects of Plate Choice, Frequency, Amplitude, and Subject's Posture on Vibration Propagation
Authors: Alizadeh‐Meghrazi Milad , Masani Kei , Popovic Milos R. , Craven Beverley Catharine 
Published: October 2012

BackgroundTo date, few pharmacologic or rehabilitation interventions for sublesional osteoporosis (SLOP) or low bone mass of the hip and knee regions after spinal cord injury (SCI) have produced significant or sustained increases in lower extremity bone mineral density. Whole body vibration (WBV) is a potential intervention for the prevention and/or treatment of SLOP.ObjectiveTo identify the optimal WBV conditions (ie, plate, frequency, amplitude, and subject posture) among men with chronic SCI during passive standing and facilitate the implementation and future evaluation of the efficacy of WBV and passive standing for prevention and treatment of SLOP in men with SCI.DesignThis phase 0 device development study assessed the lower extremity propagation characteristics of WBV in men with and without SCI by using a variety of a priori specified plates, frequencies, amplitudes, and postures that facilitate lower extremity vibration absorption while minimizing vibration propagation to the head.SettingA tertiary SCI rehabilitation center in Toronto, Canada.ParticipantsHealthy men with chronic paraplegia (n = 5) and those without SCI (n = 7), ages 20‐50 years, weight 68‐113 kg, and height 168‐188 cm.InterventionsAn EasyStand standing frame (Altimate Medical Inc, Morton, MN) was fitted onto 2 commercially available vibration platforms: WAVE (WAVE Manufacturing Inc, Windsor, Ontario, Canada) and Juvent (Juvent Medical Inc, Somerset, NJ). Accelerometers were attached to the participants' forehead, hip, knee, and ankle to measure vibration propagation. Vibration parameters evaluated were posture (knee angles of 140°, 160°, and 180° [180° for Juvent only]), vibration frequency (25 Hz, 35 Hz, and 45 Hz), and vibration amplitude (0.6 mm and 1.2 mm [WAVE only]). The subjects were exposed to all combinations of posture, frequencies, and amplitudes during the experiments (total parameter combinations: 12 WAVE and 9 Juvent).Main Outcome MeasurementsPeak‐to‐peak vibration and transmissibility of vibration were recorded and computed for each accelerometer at the tested locations.ResultsVariations in frequency generated the most noticeable changes in propagation characteristics, followed by variations in knee angle and amplitude.ConclusionsWBV therapy delivered with use of the WAVE platform with a knee angle of 140°, plate frequency of 45 Hz, and amplitude of 1.2 mm met our a priori criteria for the “optimal WBV condition.” Future studies should evaluate the therapeutic efficacy of the WAVE platform by using these parameters to maintain or augment bone mass among persons with SCI and SLOP.
Vesalius Revised. His Annotations to the 1555Fabrica1
Authors: Nutton Vivian 
Published: October 2012

AbstractTheDe humani corporis fabrica[The Fabric of the Human Body], Basle, 1543, of Andreas Vesalius is deservedly famous as the first modern book of anatomy. A second edition was published in Basle in 1555, but little is known of Vesalius’ activities after that date. This article discusses a recent find: Vesalius’ own copy of the 1555 edition, heavily annotated in preparation for a never published third edition. Vesalius made hundreds of changes to the second edition, the great majority being stylistic, altering the Latin words but not the overall meaning. There are also changes to the plates to give greater clarity or to correct mistakes by the original block-cutter. There is little new anatomical material, although Vesalius continued to meditate about what he had earlier discovered. He shows no sign of being acquainted with the findings of others, like Colombo or Falloppia, that were published after he had moved his residence from Brussels to Spain in summer 1559, perhaps leaving this volume behind. The number of annotations shows Vesalius’ passionate concern not only for accuracy but also for the most effective way of proclaiming his new anatomical message.
The Chemistry of Famine: Nutritional Controversies and the Irish Famine, c.1845–7
Authors: Miller Ian 
Published: October 2012

AbstractThe activities of Irish medical practitioners in relieving the impact of the Irish Famine (c.1845–52) have been well documented. However, analysis of the function of contemporary medico-scientificideasrelating to food has remained mostly absent from Famine historiography. This is surprising, given the burgeoning influence of Liebigian chemistry and the rising social prominence of nutritional science in the 1840s. Within this article, I argue that the Famine opened up avenues for advocates of the social value of nutritional science to engage with politico-economic discussion regarding Irish dietary, social and economic transformation. Nutritional science was prominent within the activities of the Scientific Commission, the Central Board of Health and in debates regarding soup kitchen schemes. However, the practical inefficacy of many scientific suggestions resulted in public associations being forged between nutritional science and the inefficiencies of state relief policy, whilst emergent tensions between the state, science and the public encouraged scientists in Ireland to gradually distance themselves from state-sponsored relief practices.
Between Prevention and Therapy: Gio Batta Gori and the National Cancer Institute’s Diet, Nutrition and Cancer Programme, 1974–1978
Authors: Cantor David 
Published: October 2012

AbstractThis paper explores the origins of the Diet, Nutrition and Cancer Programme (DNCP) of the National Cancer Institute (NCI) and its fate under its first director, Gio Batta Gori. The DNCP is used to explore the emergence of federal support for research on diet, nutrition and cancer following the 1971 Cancer Act, the complex relations between cancer prevention and therapeutics in the NCI during the 1970s, the broader politics around diet, nutrition and cancer during that decade, and their relations to Senator George McGovern’s select committee on Nutrition and Human Needs. It also provides a window onto the debates and struggles over whether NCI research should be funded by contracts or grants, the nature of the patronage system within the federal cancer research agency, how a director, Gio Gori, lost patronage within that system and how a tightening of the budget for cancer research in the mid-to-late 1970s affected the DNCP.
Tax Reform as Social Policy: Adjusting to change in interwar Japan
Authors: REVELANT ANDREA 
Published: October 2012

AbstractIn the wide domain of finance, taxation is one of the issues to which public opinion is most sensitive. This paper explores why tax reform was hotly debated in Japan throughout the 1920s, focusing on the policies of the two main political parties. Though a topic rarely treated by historians, this controversy reveals a wealth of information on the concerns that lay behind policy choices in years that were marked by economic instability and social unrest; it shows, in particular, how the ruling elites tried to attenuate class conflict by enhancing the redistributive function of taxes, which had thus far been subordinated to the encouragement of rapid economic growth and the financing of state investment. While these attempts deserve attention as tentative steps towards the development of a welfare state, their limits indicate that the parties, in spite of extending the suffrage during this period, retained strong links with a restricted network of established constituents. This paper dwells especially on the earliest and least studied phase of the dispute on tax reform, in order to prove that the emergence of distinct party platforms did not stem simply from tactical considerations, but was rooted in broader policy visions.
Behavior genetics and postgenomics
Authors: Charney Evan 
Published: October 2012

AbstractThe science of genetics is undergoing a paradigm shift. Recent discoveries, including the activity of retrotransposons, the extent of copy number variations, somatic and chromosomal mosaicism, and the nature of the epigenome as a regulator of DNA expressivity, are challenging a series of dogmas concerning the nature of the genome and the relationship between genotype and phenotype. According to three widely held dogmas, DNA is the unchanging template of heredity, is identical in all the cells and tissues of the body, and is the sole agent of inheritance. Rather than being an unchanging template, DNA appears subject to a good deal of environmentally induced change. Instead of identical DNA in all the cells of the body, somatic mosaicism appears to be the normal human condition. And DNA can no longer be considered the sole agent of inheritance. We now know that the epigenome, which regulates gene expressivity, can be inherited via the germline. These developments are particularly significant for behavior genetics for at least three reasons: First, epigenetic regulation, DNA variability, and somatic mosaicism appear to be particularly prevalent in the human brain and probably are involved in much of human behavior; second, they have important implications for the validity of heritability and gene association studies, the methodologies that largely define the discipline of behavior genetics; and third, they appear to play a critical role in development during the perinatal period and, in particular, in enabling phenotypic plasticity in offspring. I examine one of the central claims to emerge from the use of heritability studies in the behavioral sciences, the principle of minimal shared maternal effects, in light of the growing awareness that the maternal perinatal environment is a critical venue for the exercise of adaptive phenotypic plasticity. This consideration has important implications for both developmental and evolutionary biology.
Twin and family studies are actually more important than ever
Authors: Burt S. Alexandra 
Published: October 2012

AbstractCharney argues that the presence of inherited epigenetic effects makes twin, family, and adoption studies obsolete. This argument relies on both a faulty characterization of these studies and indirect comparisons of DNA and “neogenetic” factors. I argue that twin and family studies will in fact serve a necessary and vital role in the study of epigenetic and neogenetic processes.
The fate of heritability in the postgenomic era
Authors: MacDonald Kevin , LaFreniere Peter J. 
Published: October 2012

AbstractThis commentary argues that age changes in heritability are incompatible with Charney's theory. The new genetics must be tempered by the findings that many epigenetic phenomena are random and are linked to pathology, thus making them peripheral to the design of complex adaptations. Behavior-genetic findings are compatible with strong maternal effects; G × E correlations likely underestimate environmental effects; and G × E interactions are unlikely to be an important aspect of normal development.
Relational developmental systems: A paradigm for developmental science in the postgenomic era
Authors: Overton Willis F. , Lerner Richard M. 
Published: October 2012

AbstractThis commentary argues that the anomalies suffered by the population behavior genetics paradigm are more widespread than suggested by Charney, including many made in the field of developmental science. Further, it is argued that, according to the criteria established by Kuhn, there is and has been available an alternative scientific paradigm that provides the formative context for Charney's postgenomic view. This is the relational developmental systems paradigm.
The history of the nature/nurture issue
Authors: Pléh Csaba 
Published: October 2012

AbstractIt is worthy to supplement Charney with two historical issues: (1) There were two rival trends in the rebirth of genetic thought in the 1960s: the universal and the variation related. This traditional duality suggested that heredity cannot be equated with genetic determinism. (2) The classical debates and reinterpretation of adoption/twin studies in the 1980s regarding intelligence suggested that the environment had a more active role in unfolding the genetic program.
Epigenetic regulation of brain-derived neurotrophic factor: Implications in neurodevelopment and behavior
Authors: Schanker Benjamin D. 
Published: October 2012

AbstractSeveral recent research findings have implicated brain-derived neurotrophic factor (BDNF) as a mediator of neuronal plasticity. The BDNF gene is under extensive epigenetic regulation, which modulates how much or how little environmental experiences become encoded within neurons and neural circuits. Future scientific progress within the postgenomic paradigm requires elucidation of the functional trajectory in neogenetic and environment interactions.
A straw man's neogenome
Authors: Vilarroya Oscar 
Published: October 2012

AbstractThe neogenome has indeed changed how to understand the relationship between genotype and phenotype. However, this does not imply a paradigm shift, but simply a normal development of a young science. Charney creates a straw man out of the myth of an immutable genetics, and conveys the wrong idea that heritability studies and gene association studies are no longer valid.
Neogenomic events challenge current models of heritability, neuronal plasticity dynamics, and machine learning
Authors: Teixeira Cláudio Eduardo Corrêa , de Carvalho-Filho Nelson Monte , Silveira Luiz Carlos de Lima 
Published: October 2012

AbstractWe address current needs for neogenomics-based theoretical and computational approaches for several neuroscience research fields, from investigations of heritability properties, passing by investigations of spatiotemporal dynamics in the neuromodulatory microcircuits involved in perceptual learning and attentional shifts, to the application of genetic algorithms to create robots exhibiting ongoing emergence.
Protection mechanisms in the old-age pension systems of the CEE countries
Authors: KAWIŃSKI MARCIN , STAŃKO DARIUSZ , RUTECKA JOANNA 
Published: October 2012

AbstractSince 1990s, substantial changes in the role of the state in the social security schemes can be observed in the countries of the Central and Eastern Europe (CEE). While the general framework of social benefits in the CEE countries is still defined by the state, more and more often the task of provision of social security is transferred to the private entities. Such privatization of social policy makes the need for protection mechanism and some state guarantees even stronger. It is still the state that is responsible for the final outcome of social security systems so that is why governments are directly providing or indirectly creating safety mechanisms built-in the private market mechanism used for social purposes. The paper surveys various types of the protection mechanisms in selected CEE countries that exist in the important and already most privatized element of the social security system – the pension system. While describing the safety measures and possible guarantees, special attention is paid to the new forms that have been built up recently. The paper covers both mandatory and voluntary pension markets and identifies present and possible threats in the existing frameworks that can harm the social security. The paper concludes with general assessment and policy recommendations.
Conceptualizing, measuring and financing the legacy costs in an NDC reform
Authors: HOLZMANN ROBERT , JOUSTEN ALAIN 
Published: October 2012

AbstractThe paper provides a framework for the conceptualization, definition and measurement of the legacy costs that needs to be addressed in a reform that transforms an unfunded (or non-financial) defined benefit (NDB) scheme into an equally unfunded notional (or non-financial) defined contribution (NDC) scheme. During a transition from NDB to NDC a financing gap typically arises due to accrued to date liabilities from the old system in excess of the NDC scheme's sustainable flow of benefits. This gap – or legacy cost – needs to be estimated and best explicitly financed. We illustrate different techniques to gauge the scope of the cost. The paper applies the proposed approach to a hypothetical NDC reform in China.
Representation of the Antarctic Circumpolar Current in the CMIP5 climate models and future changes under warming scenarios
Authors: Meijers A. J. S. , Shuckburgh E. , Bruneau N. , Sallee J.‐B. , Bracegirdle T. J. , Wang Z. 
Published: October 2012

The representation of the Antarctic Circumpolar Current (ACC) in the fifth Coupled Models Intercomparison Project (CMIP5) is generally improved over CMIP3. The range of modeled transports in the historical (1976–2006) scenario is reduced (90–264 Sv) compared with CMIP3 (33–337 Sv) with a mean of 155 ± 51 Sv. The large intermodel range is associated with significant differences in the ACC density structure. The ACC position is accurately represented at most longitudes, with a small (1.27°) standard deviation in mean latitude. The westerly wind jet driving the ACC is biased too strong and too far north on average. Unlike CMIP3 there is no correlation between modeled ACC latitude and the position of the westerly wind jet. Under future climate forcing scenarios (2070–2099 mean) the modeled ACC transport changes by between −26 to +17 Sv and the ACC shifts polewards (equatorwards) in models where the transport increases (decreases). There is no significant correlation between the ACC position change and that of the westerly wind jet, which shifts polewards and strengthens. The subtropical gyres strengthen and expand southwards, while the change in subpolar gyre area varies between models. An increase in subpolar gyre area corresponds with a decreases in ACC transport and an equatorward shift in the ACC position, and vice versa for a contraction of the gyre area. There is a general decrease in density in the upper 1000 m, particularly equatorwards of the ACC core.