bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining of Climatic Parameters Using CFD in Different Window Span in Naturally Ventilated Greenhouses
Authors: Ahmet Tezcan  , Kenan Buyuktas  
Published: March 2013

The aim of this study was to compare with the measured inner air temperature and relative humidity values and the simulated values determined with Computational Fluid Dynamics (CFD) in the naturally ventilated gable-roofed single glass greenhouse located North-South direction, having 45o and 90° window spans and under no cultivation.
The measured values were recorded every 2 hours from 8 am to 18 pm using the relative humidity and air temperature sensors placed in 7 different locations. Measurements were made in case of the 45° and 90° window span openness. For CFD simulations, the SolidWorks 2011 software was used. The values of air temperature and relative humidity inside the greenhouse were simulated depending on the outside ambient conditions and structural and physical properties of greenhouse. Then, the measured values were compared with the simulated values and error rate for each sensors were determined.
As a result, it was determined minimum error rates of the measured and simulated air temperature and relative humidity in greenhouses is 4.8% and 4.7%, respectively. The study showed that the CFD can be used as a powerful tool for determining inner climatic factors in naturally ventilated greenhouses.
Les auditeurs législatifs : héros intouchables ?
Authors: Morin Danielle 
Published: March 2013

Les auditeurs législatifs seraient-ils devenus les derniers héros de la saine gestion des Administrations ? Alors que la disgrâce frappe sans délai les élus et les Administrations, que leurs décisions soient légitimes ou non, les auditeurs législatifs échappent davantage au tribunal de l’opinion publique. La fonction d’auditeur législatif semble dorénavant entourée d’une aura de crédibilité acquise pour avoir dénoncé des dérives de la gestion des affaires publiques. Mais au-delà de cette aura, la fonction et la portée du travail des auditeurs législatifs sont encore très méconnues de la population, des élus et de la presse. L’analyse de deux événements survenus récemment, alors que des vérificateurs généraux se sont retrouvés eux-mêmes dans la controverse, a fait ressortir cette méconnaissance des principaux enjeux liés à la fonction d’auditeur législatif.
Mesonephric‐type adenocarcinomas of the ovary: prevalence, diagnostic reproducibility, outcome, and value of PAX2
Authors: Köbel Martin , Kang Eun Young , Lee Sandra , Ogilvie Travis , Terzic Tatjana , Wang Linyuan , Wiebe Nicholas JP , Al‐Shamma Zainab , Cook Linda S , Nelson Gregg S , Stewart Colin JR , von Deimling Andreas , Kommoss Felix KF , Lee Cheng‐Han 
Published: July 2024

AbstractMesonephric‐type (or ‐like) adenocarcinomas (MAs) of the ovary are an uncommon and aggressive histotype. They appear to arise through transdifferentiation from Müllerian lesions creating diagnostic challenges. Thus, we aimed to develop a histologic and immunohistochemical (IHC) approach to optimize the identification of MA over its histologic mimics, such as ovarian endometrioid carcinoma (EC). First, we screened 1,537 ovarian epithelial neoplasms with a four‐marker IHC panel of GATA3, TTF1, ER, and PR followed by a morphological review of EC to identify MA in retrospective cohorts. Interobserver reproducibility for the distinction of MA versus EC was assessed in 66 cases initially without and subsequently with IHC information (four‐marker panel). Expression of PAX2, CD10, and calretinin was evaluated separately, and survival analyses were performed. We identified 23 MAs from which 22 were among 385 cases initially reported as EC (5.7%) and 1 as clear cell carcinoma. The interobserver reproducibility increased from fair to substantial (κ = 0.376–0.727) with the integration of the four‐marker IHC panel. PAX2 was the single most sensitive and specific marker to distinguish MA from EC and could be used as a first‐line marker together with ER/PR and GATA3/TTF1. Patients with MA had significantly increased risk of earlier death from disease (hazard ratio = 3.08; 95% CI, 1.62–5.85; p < 0.0001) compared with patients with EC, when adjusted for age, stage, and p53 status. A diagnosis of MA has prognostic implications for stage I disease, and due to the subtlety of morphological features in some tumors, a low threshold for ancillary testing is recommended.
A comparison of natalizumab and ocrelizumab on disease progression in multiple sclerosis
Authors: Iaffaldano Pietro , Lucisano Giuseppe , Guerra Tommaso , Paolicelli Damiano , Portaccio Emilio , Inglese Matilde , Foschi Matteo , Patti Francesco , Granella Franco , Romano Silvia , Cavalla Paola , De Luca Giovanna , Gallo Paolo , Bellantonio Paolo , Gallo Antonio , Montepietra Sara , Di Sapio Alessia , Vianello Marika , Quatrale Rocco , Spitaleri Daniele , Clerici Raffaella , Torri Clerici Valentina , Cocco Eleonora , Brescia Morra Vincenzo , Marfia Girolama Alessandra , Boccia Vincenzo Daniele , Filippi Massimo , Amato Maria Pia , Trojano Maria ,   the Italian MS Register
Published: July 2024

AbstractObjectiveNo direct comparisons of the effect of natalizumab and ocrelizumab on progression independent of relapse activity (PIRA) and relapse‐associated worsening (RAW) events are currently available. We aimed to compare the risk of achieving first 6 months confirmed PIRA and RAW events and irreversible Expanded Disability Status Scale (EDSS) 4.0 and 6.0 in a cohort of naïve patients treated with natalizumab or ocrelizumab from the Italian Multiple Sclerosis Register.MethodsPatients with a first visit within 1 year from onset, treated with natalizumab or ocrelizumab, and ≥3 visits were extracted. Pairwise propensity score‐matched analyses were performed. Risk of reaching the first PIRA, RAW, and EDSS 4.0 and 6.0 events were estimated using multivariable Cox proportional hazards models. Kaplan–Meier curves were used to show cumulative probabilities of reaching outcomes.ResultsIn total, 770 subjects were included (natalizumab = 568; ocrelizumab = 212) and the propensity score‐matching retrieved 195 pairs. No RAW events were found in natalizumab group and only 1 was reported in ocrelizumab group. A first PIRA event was reached by 23 natalizumab and 25 ocrelizumab exposed patients; 7 natalizumab‐ and 10 ocrelizumab‐treated patients obtained an irreversible EDSS 4.0, while 13 natalizumab‐ and 15 ocrelizumab‐treated patients reached an irreversible EDSS 6.0. No differences between the two groups were found in the risk (HR, 95%CI) of reaching a first PIRA (1.04, 0.59–1.84; p = 0.88) event, an irreversible EDSS 4.0 (1.23, 0.57–2.66; p = 0.60) and 6.0 (0.93, 0.32–2.68; p = 0.89).InterpretationBoth medications strongly suppress RAW events and, in the short term, the risk of achieving PIRA events, EDSS 4.0 and 6.0 milestones is not significantly different.
Strengthening human‐centered face recognition in law enforcement: Combining the Zurich face cognition test with the holistic cognitive interview
Authors: Hofer Franziska , Eigenmann Jobila , Fumagalli Carla , Glaus Markus , Ghelfi Signe 
Published: July 2024

AbstractIn the area of security, human cognition remains essential for face recognition despite advancements in technology. Law enforcement agencies (LEAs) are interested in harnessing these abilities, as recognizing people is a fundamental aspect of their work. We conducted two studies to support integrating human face recognition skills into police work. In study 1, we developed the Zurich Face Cognition Test (ZFCT), a self‐assessment tool that reliably measures the face cognition abilities of police officers with authentic police material. Our approach is complementary to the identification of super‐recognizers. In study 2, we evaluated the Holistic Cognitive Interview (HCI), a method successfully applied in the UK to recognize facial composites better. Our results indicate that the HCI provides an effective strategy for police officers to memorize images of unfamiliar faces more effectively, for example, for better recognition of wanted or missing persons.
The Dual‐Target Nanoparticles with ROS Sensitivity Inhibit the Hedgehog Signaling Pathway and Decrease Oxidative Stress in Activated Hepatic Stellate Cells to Alleviate Liver Fibrosis
Authors: Zhang Jinhang , Zhang Ting , Zhang Zijing , Jia Qingyi , Chen Jiahao , Li Jingwei , Song Haiying , Li Jiahui , Xiong Yimin , Mo Li , He Jinhan , Li Yanping 
Published: July 2024

AbstractLiver fibrosis is characterized by excess reactive oxygen species (ROS) production, hepatic stellate cell (HSC) activation, and subsequent extracellular matrix deposition. Since complex pathways regulate HSC activation, the single‐drug therapy efficacy for live fibrosis often falls short of expectations. To address this issue, an HSC‐targeted multifunctional nanoparticle (NP) delivery system co‐loaded with cyclopamine (Cyc; hedgehog inhibitor) and bilirubin (BR; ROS‐scavenger) is designed. The NP, termed RHB, is constructed via chemically conjugating hydrophobic bilirubin to hyaluronic acid (HA), followed by inserting into a cRGDyK peptide modified‐PEG shell. RHB can effectively target activated HSCs in the fibrotic liver by recognizing of the cRGDyK peptide and HA with integrin αvβ3 and CD44 due to their high expression on HSCs. During liver fibrosis, RHB NPs intelligently released Cyc in response to elevated ROS, inhibiting hedgehog signaling and subsequent HSC activation. Meanwhile, RHB NPs exhibited ROS scavenging capability and activated nuclear factor erythroid 2‐related factor 2 (Nrf2) signaling in stimulated HSCs, deactivating HSC. Cyc‐loaded RHB NPs significantly reversed the inflammatory and fibrotic phenotypes in liver fibrotic mice without evident toxicity. In summary, the multifunctional NPs dual‐targeted activated HSCs and deactivated HSC via multiple signaling, effectively ameliorating liver fibrosis, showing great promise for hepatic fibrosis treatment.
Regulatory T Cells and Their Derived Cell Pharmaceuticals as Emerging Therapeutics Against Autoimmune Diseases
Authors: Yu Liu , Fu Yiqiu , Miao Rourou , Cao Jiahui , Zhang Fan , Liu Luntao , Mei Lin , Ou Meitong 
Published: July 2024

AbstractCaused by the loss in the tolerance against self‐antigens, autoimmune diseases are chronic disorders that impact millions of individuals annually with significant economic burden. They are triggered by a deficiency in the quantity or function of regulatory T (Treg) cells, which are essential for maintaining self‐tolerance and preventing excessive immune responses. Several clinical trials over the past decade have demonstrated the safety and feasibility of certain Treg cell‐based therapies against autoimmune diseases, inspiring optimism among patients. Studies have indicated that targeted cell pharmaceuticals are significantly promising, offering superior targeting, improved biocompatibility, and prolonged blood circulation. Thus, Treg cell‐based delivery systems are also extensively studied. This review describes the role of Treg cells in the immune system both in homeostasis and in the development of autoimmunity, purification and expansion methods, derived cell pharmaceutical therapies, and the therapeutic potential for autoimmune diseases, beneficial to accelerating the industrialization and clinical translation of formulations based on Treg cells.
Defect‐Driven Oxidation Enabled V2CTx MXene with Ultralong‐Cycling and High‐Rate Capability in Aqueous K+ Storage
Authors: Liu Yujing , Liu Qi , Zhao Chengyao , Liu Liping , Liu Zhongqiu , Ying Anguo , Pang Zhibin , Sun Xuping , Chen Pu , Chen Guang 
Published: July 2024

AbstractOwing to the adverse influences of irreversible oxidation, the development of MXene‐based materials, especially those with satisfactory performance and longevity for aqueous energy storage, continues to suffer severe challenges. Herein, the strategy of targeted passivation‐supported defect‐lock‐oxygen is conceived, whereby engineered the V2CTx material for controllable partial oxidation with enhanced regioselectivity. When the material works, inside the intrinsic defects, the outward diffusion of oxidation is confined by the Lewis bases around the defects, which allows for the controllable progress of oxidation. The defect‐locked oxygen oxidizes the exposed carbon, thus forming sufficient amorphous carbons for enhancing the capacitive‐type adsorption of K‐ions. Then the oxidized defects enabled the fast kinetics via the cross‐layer transport of K‐ions. Benefiting from the strategy, the electrode assembly V2CTx‐RTIL (V2CTx equipped with room temperature ionic liquid) exhibits high capacity, good rate capability, and ultra‐longevity compared with those of the MXene materials so far reported. This work presents the first strategy of targeted passivation‐supported defect‐lock‐oxygen for high‐rate capability and super long‐cycling aqueous K+ storage and hopefully would provide the inspiration for the future design of novel electrodes.
Optically Mediated Nonvolatile Resistive Memory Device Based on Metal–Organic Frameworks
Authors: Yang Xue , Huang Jian , Li Jingjun , Zhao Yanqi , Li Hongfang , Yu Zhiyang , Gao Shuiying , Cao Rong 
Published: July 2024

AbstractMetal–organic frameworks (MOFs), characterized by tunable porosity, high surface area, and diverse chemical compositions, offer unique prospects for applications in optoelectronic devices. However, the prevailing research on thin‐film devices utilizing MOFs has predominantly focused on aspects such as information storage and photosensitivity, often neglecting the integration of the advantages inherent in both photonics and electronics to enhance optical memory. This work demonstrates a light‐mediated resistive memory device based on a highly oriented porphyrin‐based MOFs film, in which the resistance state of the memristor is modulated by light, realizing the integration of the perception and storage of optical information. The memristor shows excellent performance with a wide light range of 405–785 nm and a persistent photoconductivity phenomenon up to 8.3 × 103 s. Further mechanistic studies have revealed that the resistive switching effect in the memristor is primarily associated with the reversible formation and annihilation of Ag conductive filaments.
A General Approach to Activate Second‐Scale Room Temperature Photoluminescence in Organic Small Molecules
Authors: Ivancevic Marko R. , Wisch Jesse A. , Burlingame Quinn C. , Rand Barry P. , Loo Yueh‐Lin 
Published: July 2024

AbstractOrganic small molecules that exhibit second‐scale phosphorescence at room temperature are of interest for potential applications in sensing, anticounterfeiting, and bioimaging. However, such materials systems are uncommon—requiring millisecond to second‐scale triplet lifetimes, efficient intersystem crossing, and slow rates of nonradiative recombination. Here, a simple and scalable approach is demonstrated to activate long‐lived phosphorescence in a wide variety of molecules by suspending them in rigid polymer hosts and annealing them above the polymer's glass transition temperature. This process produces submicron aggregates of the chromophore, which suppresses intramolecular motion that leads to nonradiative recombination and minimizes triplet–triplet annihilation that quenches phosphorescence in larger aggregates. In some cases, evidence of excimer‐mediated intersystem crossing that enhances triplet generation in aggregated chromophores is found. In short, this approach circumvents the current design rules for long‐lived phosphors, which will streamline their discovery and development.
Protein Interfacial Gelation toward Shuttle‐Free and Dendrite‐Free Zn–Iodine Batteries
Authors: Zhang Shao‐Jian , Hao Junnan , Wu Han , Chen Qianru , Ye Chao , Qiao Shi‐Zhang 
Published: July 2024

AbstractAqueous zinc–iodine (Zn–I2) batteries hold potential for large‐scale energy storage but struggle with shuttle effects of I2 cathodes and poor reversibility of Zn anodes. Here, an interfacial gelation strategy is proposed to suppress the shuttle effects and improve the Zn reversibility simultaneously by introducing silk protein (SP) additive. The SP can migrate bidirectionally toward cathode and anode interfaces driven by the periodically switched electric field direction during charging/discharging. For I2 cathodes, the interaction between SP and polyiodides forms gelatinous precipitate to avoid the polyiodide dissolution, evidenced by excellent electrochemical performance, including high specific capacity and Coulombic efficiency (CE) (215 mAh g−1 and 99.5% at 1 C), excellent rate performance (≈170 mAh g−1 at 50 C), and extended durability (6000 cycles at 10 C). For Zn anodes, gelatinous SP serves as protective layer to boost the Zn reversibility (99.7% average CE at 2 mA cm−2) and suppress dendrites. Consequently, a 500 mAh Zn–I2 pouch cell with high‐loading cathode (37.5 mgiodine cm−2) and high‐utilization Zn anode (20%) achieves remarkable energy density (80 Wh kg−1) and long‐term durability (>1000 cycles). These findings underscore the simultaneous modulation of both cathode and anode and demonstrate the potential for practical applications of Zn–I2 batteries.
Polymorphic Localized Heterostructure Design for High‐Performance Amorphous/Nanocrystalline Composite Film
Authors: Huang Rui , Wang Jian , Wang Hongye , Tao Cheng , Hao Hua , Yao Zhonghua , Liu Hanxing , Shen Zhonghui , Cao Minghe 
Published: July 2024

AbstractAnalogous to linear dielectric, amorphous perovskite dielectrics characterized of high breakdown strength and low remanent polarization possess in‐depth application in the sea, land, and air fields. Amorphous engineering is a common approach to balance the inverse relationship between polarization and breakdown strength in dielectric ceramic capacitor, however, the low polarization is the major barrier limiting the improvement of energy storage density. To address this concern, the polymorphic localized heterostructure confirmed by high‐resolution transmission electron microscope (HR‐TEM) and HADDF images is constructed in BaTiO3‐Bi(Ni0.5Zr0.5)O3 amorphous/nanocrystalline composite film with SiO2 addition (BT‐BNZ‐xS, x = 3, 5, 7, 10 mol%). The stability of nanocrystalline region achieved by Si‐rich transition region and the enhancive ultra‐short‐range ordering in the amorphous region synergistically result in large breakdown strength and nonhysteretic polarized response. This polymorphic localized heterostructure optimizes the thermal stability in a wide temperature range and contributes ultrahigh energy storage density of 149.9 J cm−3 with markedly enhanced efficiency of 79.0%. This study provides a universal strategy to design the polarization behavior in other amorphous perovskite‐based dielectrics.
Breaking Down the Arsenal: Recent Progress in the Nanotherapeutic Strategies for Hepatocellular Carcinoma Treatment
Authors: Roy Sumit , Harish Vancha , Mohd Sharfuddin , Singh Sachin Kumar 
Published: July 2024

AbstractHepatocellular carcinoma (HCC) is a progressed form of advanced liver cancer and is one of the major causes of global cancer burden. The primary causes for high HCC mortality is the delayed diagnosis of the diseaseas early stage HCC is typically asymptomatic and patients frequently overlook the warning signs. Currently, the most efficacious single‐drug therapy approved by the food and drug administration (FDA) for HCC is Sorafenib and Nivolumab as a second‐line therapy for late stage HCC. Nowadays nanotechnology is used to deliver either a diagnostic tool for biomolecular imaging ortherapeutic agent. Gene therapy based on clustered regularly interspaced short palindromic repeats (CRISPR)‐CRISPR associated protein 9 (CRISPR‐Cas9) are currently studied to find a potential curative option for HCC. Natural products from plants are being extensively extracted and isolated as they may offer a promising alternative in order to control and treat HCC. They exhibit anti‐HCC effects by stimulating the immune system and by hindering various growth pathways involved in cancer development and progression. In this review article, an overview is provided on the current global incidence, ongoing systemic treatment strategies, and recent advances in nanomedicine for the management of HCC and also ongoing efforts to overcome these challenges.
Stretchable and Self‐Powered Mechanoluminescent Triboelectric Nanogenerator Fibers toward Wearable Amphibious Electro‐Optical Sensor Textiles
Authors: Wu Jiajun , Zhou Xuhui , Luo Jie , Zhou Jianxian , Lu Zecheng , Bai Zhiqing , Fan Yuan , Chen Xuedan , Zheng Bin , Wang Zhanyong , Wei Lei , Zhang Qichong 
Published: July 2024

AbstractFlexible electro‐optical dual‐mode sensor fibers with capability of the perceiving and converting mechanical stimuli into digital‐visual signals show good prospects in smart human‐machine interaction interfaces. However, heavy mass, low stretchability, and lack of non‐contact sensing function seriously impede their practical application in wearable electronics. To address these challenges, a stretchable and self‐powered mechanoluminescent triboelectric nanogenerator fiber (MLTENGF) based on lightweight carbon nanotube fiber is successfully constructed. Taking advantage of their mechanoluminescent‐triboelectric synergistic effect, the well‐designed MLTENGF delivers an excellent enhancement electrical signal of 200% and an evident optical signal whether on land or underwater. More encouragingly, the MLTENGF device possesses outstanding stability with almost unchanged sensitivity after stretching for 200%. Furthermore, an extraordinary non‐contact sensing capability with a detection distance of up to 35 cm is achieved for the MLTENGF. As application demonstrations, MLTENGFs can be used for home security monitoring, intelligent zither, traffic vehicle collision avoidance, and underwater communication. Thus, this work accelerates the development of wearable electro‐optical textile electronics for smart human‐machine interaction interfaces.
Design and Development of Metasurface Materials for Enhancing Photodetector Properties
Authors: Guan Renquan , Xu Hao , Lou Zheng , Zhao Zhao , Wang Lili 
Published: July 2024

AbstractRecently, metasurface‐based photodetectors (metaphotodetectors) have been developed and applied in various fields. Metasurfaces are artificial materials with unique properties that have emerged over the past decade, and photodetectors are powerful tools used to quantify incident electromagnetic wave information by measuring changes in the conductivity of irradiated materials. Through an efficient microstructural design, metasurfaces can effectively regulate numerous characteristics of electromagnetic waves and have demonstrated unique advantages in various fields, including holographic projection, stealth, biological image enhancement, biological sensing, and energy absorption applications. Photodetectors play a crucial role in military and civilian applications; therefore, efficient photodetectors are essential for optical communications, imaging technology, and spectral analysis. Metaphotodetectors have considerably improved sensitivity and noise‐equivalent power and miniaturization over conventional photodetectors. This review summarizes the advantages of metaphotodetectors based on five aspects. Furthermore, the applications of metaphotodetectors in various fields including military and civil applications, are systematically discussed. It highlights the potential future applications and developmental trends of metasurfaces in metaphotodetectors, provides systematic guidance for their development, and establishes metasurfaces as a promising technology.