bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of the vertebrate bone matrix: An expression analysis of the network forming collagen paralogues in amphibian osteoblasts
Authors: Aldea Daniel , Hanna Patricia , Munoz David , Espinoza Javier , Torrejon Marcela , Sachs Laurent , Buisine Nicolas , Oulion Silvan , Escriva Hector , Marcellini Sylvain 
Published: May 2013

ABSTRACTThe emergence of vertebrates is closely associated to the evolution of mineralized bone tissue. However, the molecular basis underlying the origin and subsequent diversification of the skeletal mineralized matrix is still poorly understood. One efficient way to tackle this issue is to compare the expression, between vertebrate species, of osteoblastic genes coding for bone matrix proteins. In this work, we have focused on the evolution of the network forming collagen family which contains the Col8a1, Col8a2, and Col10a1 genes. Both phylogeny and synteny reveal that these three paralogues are vertebrate‐specific and derive from two independent duplications in the vertebrate lineage. To shed light on the evolution of this family, we have analyzed the osteoblastic expression of the network forming collagens in endochondral and intramembraneous skeletal elements of the amphibian Xenopus tropicalis. Remarkably, we find that amphibian osteoblasts express Col10a1, a gene strongly expressed in osteoblasts in actinopterygians but not in amniotes. In addition, while Col8a1 is known to be robustly expressed in mammalian osteoblasts, the expression levels of its amphibian orthologue are dramatically reduced. Our work reveals that while a skeletal expression of network forming collagen members is widespread throughout vertebrates, osteoblasts from divergent vertebrate lineages express different combinations of network forming collagen paralogues. J. Exp. Zool. (Mol. Dev. Evol.) 320B: 375–384, 2013. © 2013 Wiley Periodicals, Inc.
Controls of earthquake faulting style on near field landslide triggering: The role of coseismic slip
Authors: Tatard L. , Grasso J. R. 
Published: May 2013

AbstractWe compare the spatial distributions of seven databases of landslides triggered byMw=5.6–7.9 earthquakes, using distances normalized by the earthquake fault length. We show that the normalized landslide distance distributions collapse, i.e., the normalized distance distributions overlap whatever the size of the earthquake, separately for the events associated with dip‐slip, buried‐faulting earthquakes, and surface‐faulting earthquakes. The dip‐slip earthquakes triggered landslides at larger normalized distances than the oblique‐slip event of Loma Prieta. We further identify that the surface‐faulting earthquakes of Wenchuan, Chi‐Chi, and Kashmir triggered landslides at normalized distances smaller than the ones expected from theirMw ≥ 7.6 magnitudes. These results support a control of the seismic slip (through amplitude, rake, and surface versus buried slip) on the distances at which landslides are triggered. In terms of coseismic landslide management in mountainous areas, our results allow us to propose distances at which 95 and 75% of landslides will be triggered as a function of the earthquake focal mechanism.
3 Tesla 1H MR spectroscopy of hip bone marrow in a healthy population, assessment of normal fat content values and influence of age and sex
Authors: Pansini Vittorio , Monnet Aurélien , Salleron Julia , Hardouin Pierre , Cortet Bernard , Cotten Anne 
Published: May 2013

PurposeTo evaluate in a healthy population normal spectroscopic fat content (FC) values of the hip bone marrow and to assess the influence of age and sex on bone marrow conversion.Materials and MethodsEighty volunteers (40 men; 40 women; ages: 20–60 years; divided into four consecutive groups) underwent acetabulum, femoral head, femoral neck, greater trochanter, and diaphysis localized 1H MR spectroscopy. FC values of each anatomical site were obtained according to the following formula: Fat content = CH2/(CH2 + Water)*100. To assess bone marrow conversion, a spectroscopic conversion index (SCI) was calculated as FC neck/FC greater trochanter.ResultsFC values showed a gradient as follows: greater trochanter > femoral head > femoral neck > diaphysis > acetabulum in every age group both in men and in women. SCI increased with age both in men and women, showing lower values in women for every age group.ConclusionWe obtained normal spectroscopic FC values from different areas of the hip, according to age and sex. These values may be used as reference values to evaluate, by the means of 1H MR spectroscopy, pathological conditions affecting hip bone marrow. J. Magn. Reson. Imaging 2014;39:369–376. © 2013 Wiley Periodicals, Inc.
Method development: Raman spectroscopy‐based histopathology of oral mucosa
Authors: Cals Froukje L. J. , Bakker Schut Tom C. , Koljenović Senada , Puppels Gerwin J. , de Jong Robert J. Baatenburg 
Published: May 2013

An earlier and more accurate detection of (small) cancerous and precancerous lesions in the oral cavity is essential to improve the prognosis of oral squamous cell carcinomas. Raman spectroscopy is being pursued as a potential method to realize this improvement, since the technique provides objective information on a biochemical level and can be used for real‐time guidance of the diagnostic procedure.Since oral mucosal tissue is inhomogeneous and comprises different layers and histological structures, a good understanding of the signal contributions of the individual layers and structures is required for an accurate interpretation of in vivo tissue spectra measurement volumes. The aim of this study was to create a standardized method to collect and analyse the spectral contributions of individual histopathological structures in oral mucosa.The method is based on Raman microspectroscopic mapping of unstained frozen tissue sections and subsequent histopathological annotation of the features in the resulting Raman images. The obtained annotated reference spectra were used as input in an unsupervised hierarchical cluster analysis in order to determine the spectral characteristics and variance within one histo(patho)logical structure.The described method resulted in an annotated database of Raman spectral characteristics of individual histopathological structures encountered in oral tissue. This database can be used as input for the development of classification and quantification algorithms, in order to achieve a high specificity and sensitivity for clinical diagnostic instruments. Additionally, this database can be used to optimize the exact location and measurement volume of in vivo measurements. Copyright © 2013 John Wiley & Sons, Ltd.
Simultaneous SAXS and WAXS Study on the Guest Exchange Process of Syndiotactic Polystyrene: Crystalline Complex Formation with Triethylene Glycol Dimethyl Ether
Authors: Kaneko Fumitoshi , Seto Naoki , Sasaki Keita , Sakurai Shinichi , Kimura Tsuyoshi 
Published: May 2013

AbstractSyndiotactic polystyrene (sPS) forms cocrystals with a variety of chemical compounds. The guest molecules can be easily replaced with other kinds of molecules under certain conditions. The guest‐exchange process, on exposure to liquid triethylene glycol dimethyl ether (TEGDME), is followed by time‐resolved simultaneous small‐angle and wide‐angle X‐ray scattering to clarify the structure changes in molecular‐level and higher‐order structures. It is clarified that the exchange from the original guest chloroform to the new guest TEGDME takes place mainly after a certain incubation time, in parallel with the expansion of the lamellar period. The occurrence of the ϵ cocrystal during this process and the influence of the amount of chloroform on the incubation time are also studied.magnified image
Classic models for dynamic contrast‐enhanced MRI
Authors: Sourbron Steven P. , Buckley David L. 
Published: May 2013

Dynamic contrast‐enhanced MRI (DCE‐MRI) is a functional MRI method where T1 ‐weighted MR images are acquired dynamically after bolus injection of a contrast agent.The data can be interpreted in terms of physiological tissue characteristics by applying the principles of tracer‐kinetic modelling. In the brain, DCE‐MRI enables measurement of cerebral blood flow (CBF), cerebral blood volume (CBV), blood–brain barrier (BBB) permeability–surface area product (PS) and the volume of the interstitium (ve). These parameters can be combined to form others such as the volume‐transfer constant Ktrans, the extraction fraction E and the contrast‐agent mean transit times through the intra‐ and extravascular spaces.A first generation of tracer‐kinetic models for DCE‐MRI was developed in the early 1990s and has become a standard in many applications. Subsequent improvements in DCE‐MRI data quality have driven the development of a second generation of more complex models. They are increasingly used, but it is not always clear how they relate to the models of the first generation or to the model‐free deconvolution methods for tissues with intact BBB. This lack of understanding is leading to increasing confusion on when to use which model and how to interpret the parameters.The purpose of this review is to clarify the relation between models of the first and second generations and between model‐based and model‐free methods. All quantities are defined using a generic terminology to ensure the widest possible scope and to reveal the link between applications in the brain and in other organs. Copyright © 2013 John Wiley & Sons, Ltd.
Relationship between cancer‐related fatigue and personality in patients with breast cancer after chemotherapy
Authors: Wang Shu‐Hong , He Guo‐Ping , Jiang Ping‐Lan , Tang Li‐Li , Feng Xiao‐Min , Zeng Cui , Wang Guo‐Fei 
Published: May 2013

AbstractBackgroundThis study aimed to explore the relationship between cancer‐related fatigue (CRF) and personality in patients with breast cancer after chemotherapy.MethodsA cross‐sectional study was conducted to study the relationship between CRF and personality in breast cancer patients after chemotherapy. CRF and personality were measured by the cancer fatigue score and the Eysenck Personality Questionnaire, respectively.ResultsA total of 300 breast cancer patients who had received chemotherapy were recruited to this study. Eysenck Personality Questionnaire scores of psychoticism, introversion, and extroversion in the patients were lower than the norm level (p < 0.01), but those of neuroticism and lie were higher than the norm level (p < 0.01). Multivariate analyses showed positive correlation between psychoticism and affective fatigue, neuroticism and total fatigue, and physical fatigue and cognitive fatigue. Multivariate analyses also showed negative correlation between introversion or extroversion and total fatigue, physical fatigue or affective fatigue, and lie and total fatigue or cognitive fatigue.ConclusionsThere was CRF in patients with breast cancer after chemotherapy. Psychoticism, extroversion/introversion, neuroticism, and lie are correlated with CRF in breast cancer patients after chemotherapy. Copyright © 2013 John Wiley & Sons, Ltd.
Migration and the Employer Perspective: Pitfalls and Potentials for a Future Research Agenda
Authors: Scott Sam 
Published: May 2013

ABSTRACTThere is a pervasive economic rationale behind all forms of labour migration. The paper identifies an emergent but still quite limited body of research that engages with and explores this rationale. More specifically, it is interested in research looking at contemporary patterns and processes of migration from the perspective of employers and employment agencies. There has to date been no attempt to review employer‐based research on migration or to identify emergent narratives that could help to guide future academic enquiry. The paper addresses this omission by highlighting five embryonic employer‐orientated migration research themes. It begins, however, by noting some of the limitations of employer‐based empirical research. These limitations, it is argued, are significant but not insurmountable and should not be used as an excuse to overlook employers' role in shaping, and often fundamentally underpinning, the demand for immigration. Copyright © 2013 John Wiley & Sons, Ltd.
Study of hydrogenated AlN as an anti‐reflective coating and for the effective surface passivation of silicon
Authors: Krugel Georg , Sharma Aashish , Wolke Winfried , Rentsch Jochen , Preu Ralf 
Published: May 2013

AbstractStacks of aluminum oxide and silicon nitride are frequently used in silicon photovoltaics. In this Letter, we demonstrate that hydrogenated aluminum nitride can be an alternative to this dual‐layer stack. Deposited on 1 Ω cm p‐type FZ silicon, very low effective surface recombination velocities of 8 cm/s could be reached after firing at 820 °C. This excellent passivation is traced back to a high density of fixed charges at the interface of approximately –1 × 1012 cm–2 and a very low interface defect density below 5 × 1010 eV–1 cm–2. Furthermore, spectral ellipsometry measurements reveal that these aluminum nitride layers have ideal optical properties for use as anti‐reflective coatings. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
THE ECONOMIC VALUE OF MISSOURI RIVER RECREATION: ESTIMATES FROM THE MISSOURI RIVER PUBLIC USE ASSESSMENT
Authors: Treiman T. B. , Sheriff S. L. , Renken R. B. , Loomis J. 
Published: May 2013

ABSTRACTExit interviews with visitors were used to estimate public use on and along 811 miles of the Missouri River from Gavins Point Dam near Yankton, South Dakota, to the river's mouth near St. Louis, Missouri, during a 13‐month period in 2004 and 2005. We estimated both types and amount of public use and the economic value of the river to the users. Economic values of recreation to the public were estimated using both the Travel Cost Method (TCM) and the Contingent Valuation Method (CVM). For these public access and areas, an estimated 2 042 980 individual visits were made to the river, with total economic benefits of the river to users estimated at $12.79 per individual visit (TCM) and $23.65 per individual visit (CVM).We discuss methodological differences between the two methods and the potential utility of this information to river management. Copyright © 2013 John Wiley & Sons, Ltd.
Experimental Electron Density Studies of Inorganic Materials
Authors: Stokkebro Schmøkel Mette , Overgaard Jacob , Brummerstedt Iversen Bo 
Published: May 2013

AbstractThe electron density of a molecular scale system is probably the most information‐rich observable in natural science, and experimental electron density determination based on X‐ray diffraction is a strong field of modern crystallography. Most studies concern small molecule organic or metal‐organic crystals, and indeed the experimental method and the subsequent data modeling and analysis have become a very versatile tool for such systems. However, inorganic materials in the form of high‐symmetry dense solids, often with extended structures and containing heavy atoms, represent one of the most serious challenges to the X‐ray electron density technique. For inorganic materials the scattering from the valence electrons is minute compared with the core electron scattering, and systematic errors such as extinction and absorption can be severe. In some sense studies of inorganic materials can be used as a benchmark for the current level of electron density analysis using X‐ray diffraction. Here we discuss the special challenges that face X‐ray electron density studies of inorganic materials. We discuss the special experimental requirements – basically the ideal X‐ray electron density experiment shines stable, intense, high energy, monochromatic X‐rays on minute single crystals at the lowest possible temperature, and the diffracted intensities are recorded on detectors with low background noise and large dynamic range. We also address the specific problems encountered when modeling very diffuse valence electrons in heavy atoms. Furthermore, for light atom materials topological analysis is often used as an analysis tool to extract information e.g. about chemical bonding, but for inorganic materials many of the commonly used descriptors are less informative, and other approaches are called for.
A Metallosupramolecular Octahedron Assembled from Twelve Copper(I) Metal Ions and Six 4,4′‐(1,2‐Phenylene)bis(3,5‐dimethylpyrazol‐1‐ide) Ligands
Authors: Grzywa Maciej , Bredenkötter Björn , Denysenko Dmytro , Spirkl Sebastian , Nitek Wojciech , Volkmer Dirk 
Published: May 2013

AbstractThe novel coordination compound [CuI12(C16H16N4)6]·8DMAc, (2), (DMAc = N, N‐dimethylacetamide) was prepared in solvothermal or microwave assisted reaction. It contains four metallamacrocyclic trinuclear copper(I) pyrazolate coordination units, which occupy four (opposite) faces of an imaginary metallosupramolecular octahedron. Six (4,4′‐(1,2‐phenylene)bis(3,5‐dimethylpyrazol‐1‐ide) ligands (L12–) are placed at the corners of the octahedron. Crystals of the free ligand H2L1 [1,2‐bis(3,5‐dimethyl‐1H‐pyrazol‐4‐yl)benzene, (1)], and [CuI12(C16H16N4)6]·8DMAc (2), were characterized by single‐crystal X‐ray structure analyses. Lingand 1 crystallizes in the monoclinic crystal system, with: a = 9.0118(9), b = 14.0075(11), c = 11.7484(11) Å, β = 104.945(5)°, V = 1432.9(2) Å3, space group P21/c (no. 14). Compound 2 crystallizes in the tetragonal system, with: a = b = 19.506(5), c = 42.888(5) Å, V = 16318(6) Å3, space group I41/amd (no. 141). Compound 2 represents a porous structure, where each metallosupramolecular octahedron encloses a solvent‐filled cavity of 889 Å3 (accounting for 6 DMAc molecules, 21.8 % of the cell volume). The incomplete crystal packing arrangement of adjacent [CuI12(C16H16N4)6] moieties in addition leads to solvent‐filled interstitial voids accounting to 8.1 % of the cell volume. Removing solvent molecules in vacuo is accompanied by reversible structural changes, leading to a partial loss of porosity, as revealed by Ar‐BET sorption analysis. Compounds 1 and 2 were further characterized by elemental and thermogravimetric analysis, X‐ray powder diffraction, FTIR‐, UV/Vis‐ and fluorescence spectroscopy. Preliminary results on the activation of molecular oxygen by compound 2 are presented.
Halogen Bonding in the Assembly of a 1D Cadmium(II) Polymer Based on Chlorendic Acid (HET)
Authors: Cui Pei‐Pei , Cui Lun‐Feng , Zhang Liang‐Liang , Sun Dao‐Feng 
Published: May 2013

AbstractA new complex based on chlorendic acid (HET), [Cd8(HET)8(DMF)4(H2O)12]·8DMF (1) was synthesized by liquid evaporate method from the mixture of HET and Cd(NO3)2·4H2O. Single crystal X‐ray analysis reveals that the structure of complex 1 features a one‐dimensional (1D) wave chain that is further assembled into three‐dimensional (3D) framework directed by supramolecular interactions, including hydrogen bond, Cl···Cl halogen bond, and so on. To the best of our knowledge, this is the first metal‐organic coordination polymer based on chlorendic acid (HET). The luminescent property and thermal stability of complex 1 were also discussed.
Influence of Prophylactic Neck Dissection on Rate of Retreatment for Papillary Thyroid Carcinoma
Authors: Hartl Dana M. , Mamelle Elisabeth , Borget Isabelle , Leboulleux Sophie , Mirghani Haïtham , Schlumberger Martin 
Published: May 2013

AbstractBackgroundProphylactic neck dissection (PND) for papillary thyroid cancer is controversial. The objective of this study was to analyze the influence of PND on the rate of retreatment.MethodsIn this retrospective case‐control study, papillary thyroid carcinomas >10 mm without ultrasonographic evidence of nodal disease (cN0) were treated with total thyroidectomy (TT) or TT with bilateral central compartment PND. All received postoperative radioactive iodine (131I) and were followed for at least 1 year. We compared the rate of retreatment (surgery or 131I).ResultsAltogether, 246 patients (mean age 46 years, 78 % women) underwent TT (n = 91) or TT + PND (n = 155). The groups were similar in age, sex, tumor size, and follow‐up (median 6.3 years) (p > 0.05). Overall, 11 (12 %) of the patients in the TT group underwent reoperation in the central compartment for recurrence versus 3 (2 %) in the TT + PND group (p < 0.001). There were 1.18 administrations of 131I for the TT group versus 1.08 for the TT + PND group (p = 0.08). The average cumulative dose of 131I was 3.9 ± 1.8 GBq for the TT group and 3.8 ± 1.3 GBq for the TT + PND group (p = 0.52). Actuarial (Kaplan‐Meier) 5‐year retreatment rates were 14.7 % in the TT group and 6.5 % in the TT + PND group (p = 0.01, log‐rank). The rate of permanent recurrent nerve paralysis was 2 % for the TT group and 1 % for the TT + PND group (p = 0.98). The rates of permanent hypoparathyroidism were 7 versus 3 %, respectively (p = 0.12).ConclusionsFive‐year retreatment rates were lower in patients treated with PND, with no added permanent morbidity.
Genetic Risk Assessment for Women with Epithelial Ovarian Cancer: Referral Patterns and Outcomes in a University Gynecologic Oncology Clinic
Authors: Petzel Sue V. , Vogel Rachel Isaksson , Bensend Tracy , Leininger Anna , Argenta Peter A. , Geller Melissa A. 
Published: May 2013

AbstractLittle is known about genetic service utilization and ovarian cancer. We identified the frequency and outcome of genetic counseling referral, predictors of referral, and referral uptake for ovarian cancer patients. Using pathology reports, we identified all epithelial ovarian cancer patients seen in a university gynecologic oncology clinic (1/04–8/06). Electronic medical records (EMR) were used to document genetic service referral, time from diagnosis‐to‐referral, point‐in‐treatment at referral, personal/family cancer history, demographics, and genetic test results. Groups were compared using chi‐squared and Fisher's exact test for categorical variables and t‐tests for continuous variables. The study population consisted of 376 women with ovarian cancer, 72 (19 %) of who were referred for genetic counseling/testing, primarily during surveillance. Of those referred, 42 (58 %) had personal or family genetic counseling and 34 (47 %) were ultimately tested or identified due to known family mutation. Family history and prior cancer were associated with referral. Family history, living in a larger community, higher‐stage disease, and serous histology were associated with undergoing genetic counseling. Risk assessment identified 20 BRCA1/2 (5.3 %) and 1 HNPCC (0.3 %) mutation carriers. Based on recent estimates that 11.7–16.6 % of women with ovarian cancer are BRCA carriers and 2 % are HNPCC carriers, results suggest under‐identification of carriers and under‐utilization of genetic services by providers and patients. Interventions to increase medical providers’ referrals, even in a specialized oncology clinic, are necessary and may include innovations in educating these providers using web‐based methods. Ease of referral by the introduction of an electronic cancer genetic referral form represents another new direction that may increase genetic risk assessment for high‐risk women with ovarian cancer.
Women's Associations and the Emergence of a Social State: Protection for Mothers and Children in Buenos Aires, 1920–1940
Authors: TOSSOUNIAN CECILIA 
Published: May 2013

AbstractThis paper examines the women's association movement in Buenos Aires between 1920 and 1940, and its connection with the emergence of a social state. Subsidised by the state, associations led by upper-class women provided a significant number of social assistance services to mothers, working women and children, and had a notable impact on the design of social policy. While historiography concurs that by 1930 the significance of this charitably oriented women's movement had started to decline, being replaced by public welfare services, this paper seeks to question such a conclusion by analysing three of the most important women's social welfare associations in the period and showing how, having become the maternal face of the state, they retained a central role in the provision of social assistance until well into the 1930s, thus helping to prevent the state from becoming a ‘colossal bureaucratic machine’.