bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of choir-singing on self-reported embodied cognition in persons with dementia. A pilot study
Authors: Ridder Hanne Mette , Anderson-Ingstrup Jens , Ridder Lukas Ochsner 
Published: August 2024

With an understanding of dementia through the lens of embodied cognition and a musical sense of the dynamics of the body, a fundamental continuity of personhood is possible. With music and singing, body and mind are positively affected for persons with dementia, and with promising evidence on emotional wellbeing during choir-singing. Based on this, we carried out a pilot-study to explore the effect of choir-singing on self-reported embodied cognition in persons with dementia. As part of a Danish TV documentary on choir-singing, 17 participants with a mean age of 71 years took part in choir rehearsals and a concert. The majority of the participants had moderate/severe dementia, and 29% mild dementia. Altogether 164 self-report forms were analysed and showed a highly significant increase in embodied cognition from before to after choir-singing. The results provide initial evidence that choir-singing for persons with dementia positively influence the participants’ self-reported embodied cognition. Further, the positive effect seemed to increase in line with increasing level of dementia. The 8-item Embodied Cognition in Dementia Assessment Scales (EmDAS) showed good internal reliability and promising properties for evaluating the effect of embodied cognition. For future research, controlled trials with larger samples are needed to provide evidence of choir-singing for persons in various stages of dementia.
Identification of Dementia & Mild Cognitive Impairment in Chinese Elderly Using Machine Learning
Authors: Ying Tong-Tong , Zhuang Li-Ying , Xu Shan-Hu , Zhang Shu-Feng , Huang Li-Jun , Gao Wei-Wei , Liu Lu , Lai Qi-Lun , Lou Yue , Liu Xiao-Li 
Published: August 2024

Objective To assess the role of Machine Learning (ML) in identification critical factors of dementia and mild cognitive impairment. Methods 371 elderly individuals were ultimately included in the ML analysis. Demographic information (including gender, age, parity, visual acuity, auditory function, mobility, and medication history) and 35 features from 10 assessment scales were used for modeling. Five machine learning classifiers were used for evaluation, employing a procedure involving feature extraction, selection, model training, and performance assessment to identify key indicative factors. Results The Random Forest model, after data preprocessing, Information Gain, and Meta-analysis, utilized three training features and four meta-features, achieving an area under the curve of 0.961 and a accuracy of 0.894, showcasing exceptional accuracy for the identification of dementia and mild cognitive impairment. Conclusions ML serves as a identification tool for dementia and mild cognitive impairment. Using Information Gain and Meta-feature analysis, Clinical Dementia Rating (CDR) and Neuropsychiatric Inventory (NPI) scale information emerged as crucial for training the Random Forest model.
The status quo and influencing factors of clinical research nurses’ participation in preoperative blood sampling in patients with pulmonary nodules
Authors: Yuan Huadi , Lan Meijuan , He Hong , Hong Pinghua , Gao Liyan 
Published: August 2024

Background: Under-recruitment in clinical trials has become a worldwide problem, and has many causes that need to be understood. Clinical Research Nurses (CRNs) provide a new research perspective. Aim: To understand the current situation about the informed consent rate after the participation of CRNs and analyse the possible influencing factors. Methods: This cross-sectional study was conducted at a hospital. A convenience sample was used to study patients with pulmonary nodules who underwent day surgery from March to May 2023. Patients first received information from doctors and a second session by CRNs was provided for those who initially were hesitant about the research. A questionnaire survey was conducted using an online survey platform to collect information. Results: After education by doctors, 208 patients were hesitant and CRNs conducted a second education session, the CICARE model was used for communication. Following this session a further 161 patients were willing to participate. Finally, 374 patients were willing to participate. Related factors include age, education level and the attitude of self-assessed family members towards their participation in clinical projects. Conclusions: CRNs’ participation can improve patients’ willingness to participate. It is crucial to pay attention to the role of CRNs and propose a new model of CRNs involvement in clinical research based on identifying factors.
Perioperative efficiency of sugammadex following minimally invasive gastric sleeve surgery: A superiority trial
Authors: Samad Mawadah , Sutherland Macey , Ganier Donald , Broussard David , Koveleskie Joseph , Nossaman Vaughn E , Nossaman Bobby D 
Published: August 2024

Background: Studies have proposed that the routine use of sugammadex could provide perioperative time savings and a reduction in the incidence of postoperative nausea and vomiting. The purpose of this study was to test the effectiveness of sugammadex on perioperative times and on the incidences of adverse events when compared with the active control, neostigmine, for minimally invasive gastric sleeve surgery. Methods: Following institutional review board approval, patient characteristics, type of primary neuromuscular blocking reversal agents, operating room discharge times, post-anaesthesia care unit recovery times, and incidences of and treatment for postoperative nausea and vomiting and orotracheal reintubation were the measures of interest. Superiority testing determined the between-group means differences of the reversal agents on the two perioperative time periods of interest. Results: Superiority testing demonstrated no improvement of the two perioperative times with sugammadex. There was no clinical difference in the incidence of postoperative nausea and vomiting or in the number of antiemetic doses received in the post-anaesthesia care unit between the two groups. Finally, the two orotracheal reintubations in the post-anaesthesia care unit were in the sugammadex administered group. Conclusion: These results with sugammadex provide no perioperative time savings or reduce the incidence and treatment for postoperative nausea and vomiting in the post-anaesthesia care unit when compared with neostigmine.
Comparison of combination skin substitutes and skin grafts versus skin grafts only for treating wounds measured by Vancouver Scar Scale: A comprehensive meta-analysis
Authors: Putri Indri Lakhsmi , Sindhu Florencia Christina , Aisyah Imaniar Fitri , Pramanasari Rachmaniar , Wungu Citrawati Dyah Kencono 
Published: August 2024

Background: Skin is the largest organ in the body and has multiple significant functions. A malformation or injury that compromises its integrity can lead to major issues or even mortality. Wound healing is a vital physiological process of the human skin which facilitates the repair of any damage and the preservation of homeostasis. Possible complications or infections that are fatal may ensue if the patient does not recover within the specified time. Therefore, it is essential to develop biomaterials which facilitate tissue regeneration and exhibit robust biological properties. We conducted a meta-analysis of randomized controlled trials to compare combinations of skin replacements and skin grafts to skin grafts alone for wound treatment, as measured by the Vancouver Scar Scale. Methods: This meta-analysis utilized various databases, including as PubMed, ProQuest, Web of Science, Science Direct, Scopus, EBSCOhost, and ClinicalTrials.gov, to conduct a comprehensive search for randomized controlled trials that compared the effectiveness of combined skin substitutes and skin grafts to skin grafts alone in the treatment of wounds. The results primarily consisted of scar features assessed using the Vancouver Scar Scale. Results: Meta-analysis was conducted on a sample of 216 participants from 7 randomized controlled trials. The trials were conducted from 2002 to 2015. The study demonstrated that the use of skin substitutes resulted in a statistically significant improvement in Vancouver Scar Scales ratings compared to skin grafts alone. The mean change was 1.38 (95% CI: 0.13–2.63; p = 0.03). Conclusion: This meta-analysis indicates that the use of skin replacements provides substantial advantages and effectively aids in the closure of wounds. There is no inherent superiority among different skin substitutes. Instead, their suitability for specific patient wound circumstances is the determining factor. A comprehensive and advantageous skin substitute of significant magnitude is needed, rather than relying solely on grafts.
Predictive Value of the KOJI AWARENESS Self-Evaluation System for Running Injuries in Elite Male Long-Distance Runners: A Prospective Cohort Study
Authors: Murofushi Koji , Mitomo Sho , Hirohata Kenji , Furuya Hidetaka , Katagiri Hiroki , Kaneoka Koji , Hara Susumu , Yagishita Kazuyoshi 
Published: August 2024

Background: The KOJI AWARENESS (KA) test is a practical self-evaluation tool that assesses body movements and may help develop individual conditioning plans to improve movement function. However, the association between preseason KA scores and in-season injury occurrence remains unexplored. Purpose: To investigate whether the KA self-screening test score can predict running-related injuries in elite long-distance runners. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 47 elite college male long-distance runners (age, 18-22 years) were enrolled in this study in June 2022. The participants underwent the KA self-screening test to assess preseason upper limb, core, and lower limb function. Running-related injuries with a training time loss of >3 weeks were tracked for 6 months during the season. The participants were divided into injury and noninjury groups, and between-group comparisons and receiver operating characteristic (ROC) curve analysis were used to determine the association between the KA scores and the injury incidence. Chi-square tests and risk ratios were calculated based on the cutoff value- and injury-based grouping. Results: Among the runners, 10 (21.3%) sustained an injury. There were no significant differences in the demographic characteristics between the injury and noninjury groups. The injury group had significantly lower KA scores than the noninjury group (median, 44.5 [interquartile range, 43-46.8] vs median, 48 [interquartile range, 46-50], respectively; P = .009). The ROC curve analysis determined a cutoff value of 46.5 points (sensitivity, 73%; specificity, 63.6%), indicating that the KA scores exhibited a relatively high predictive value for running-related injuries (area under the ROC curve, 0.764 [95% CI, 0.600-0.930]). The risk ratio for group division based on the cutoff value was 2.590 (95% CI, 1.329-5.047). Conclusion: These findings demonstrated that the KA test is an effective self-screening tool for predicting the risk of running-related injuries in elite male long-distance runners.
Young Adult and Parent Willingness to Pay for Meningococcal Serogroup B Vaccination
Authors: Huang Liping , Srivastava Amit , Fairchild Angelyn , Whittington Dale , Johnson Reed 
Published: August 2024

Introduction. Serogroup B (MenB) is the leading cause of invasive meningococcal disease among adolescents and young adults in the United States. The US Advisory Committee on Immunization Practices (ACIP) recommends MenB vaccination based on shared clinical decision making between patients and providers. However, suboptimal understanding of these recommendations could contribute to low vaccination awareness and coverage. Understanding young adult and parent expectations of their health care providers (HCPs) and the value they place on vaccine information could help inform a consistent approach to HCP MenB vaccination discussions and recommendations. Methods. Data collected via a discrete-choice experiment online survey were used to evaluate preferences and willingness to pay regarding MenB vaccination among US parents and young adults in 2019. Results. Of 2,388 respondents with valid data, 1,185 were parents of children aged 12 to 25 y, and 1,203 were young adults aged 18 to 25 y. Approximately 70% of parents and young adults indicated that they would react negatively if their HCP chose not to initiate a discussion with them about MenB vaccines. Neither parents nor young adults were willing to pay for additional time for MenB vaccine discussions with their HCP but were willing to pay an average of $416 and $282, respectively, for the vaccine. For parents and young adults, greater willingness to pay was associated with a provaccination attitude and the opinion that the HCP has a moral obligation to discuss the MenB vaccine with them. Conclusion. Both parents and young adults felt their HCP is responsible for initiating a discussion about MenB vaccination and disease risk and were willing to pay for the vaccine. These findings should help inform ACIP recommendations for meningococcal vaccination. Highlights ACIP recommends shared clinical decision making for MenB vaccination. Data were collected from young adults and parents of adolescents by online survey. We measured values and consultation preferences on MenB disease and vaccination. Young adults/parents strongly preferred doctor-initiated MenB vaccine discussion. Respondents were willing to pay for a MenB vaccine.
India’s Trade Integration with the Republic of Korea: A Services Trade Analysis of India–Korea CEPA
Authors: Gupta Pralok 
Published: August 2024

India and the Republic of Korea signed the India–Korea Comprehensive Economic Partnership Agreement (CEPA) in 2009 and have been actively engaged in upgrading this agreement since 2015. This article analyses the India–Korea CEPA from a services trade perspective. It compares the services commitments undertaken by the two countries under the India–Korea CEPA and the WTO. It further assesses the gains for India from the CEPA by comparing services exports and imports before and after the CEPA came into operation. The study finds that India’s services exports to Korea have increased more than its imports from Korea, resulting in an increase in India’s services trade surplus with Korea after the CEPA. The study recommends exploring bilateral labour agreements with Korea to facilitate the movement of natural persons in specific sectors and further liberalisation commitments from Korea in services of India’s interests during the CEPA upgradation. JEL Classification: F13, F14, F15
Intertemporal Decision-Making, Diabetes Self-Management, and Health Outcomes in Patients With Type 2 Diabetes
Authors: Jin Pina , Wang Xiaojing , Li Aihua , Dong Huan , Wu Kailu , Wen Aichun , Ji Meihua 
Published: August 2024

Purpose The purpose of this study was to identify the independent factors associated with intertemporal decision-making and to examine its relationship with diabetes self-management behaviors, glucose variability, and diabetes complications in patients with diabetes. Methods A cross-sectional study using convenience sampling (n = 368) was conducted in patients with type 2 diabetes (T2DM) between November 2021 and April 2023. Data were collected using self-reported questionnaires and retrieval of clinical information from medical records. Intertemporal decision-making was operationalized using delay discounting. The outcome variables included diabetes self-management behaviors, A1C, diabetic retinopathy, and carotid artery disease. Hierarchical regression and binary logistic regression models were used to explore the relationships among intertemporal decision-making, self-management, A1C, and carotid artery disease. Results The analyses showed that intertemporal decision-making was negatively associated with physical activity and carotid artery disease, in which individuals with lower delay discounting tended to have healthier physical activity; when the delay discounting rate increased 1 unit, the risk of the carotid artery disease increased by 39.8%. Conclusions The study reveals that a lower delay discounting can promote healthier physical activity and decrease the incidence of carotid artery disease. These results offer new knowledge for researchers and clinicians to consider intertemporal decision-making in developing interventional programs to improve physical activity and reduce carotid artery complication in patients with T2DM when providing care.
The Impact of the Sonographic Findings Within the Epididymis on the Differential Diagnosis of Acute Scrotum
Authors: Shabani Elham , Tanha Hosein , Moradi Ali , Khoroushi Farzaneh , Alamdaran Seyed Ali 
Published: August 2024

Objective: The aim of this study was to assess the sonographic changes within the testis, epididymis, and the corresponding appendages, in contributing to the pediatric differential diagnosis, of an acute scrotum. Materials and Methods: A retrospective extraction of pediatric patients’ (age <13 years) data was completed for those initially seen with an acute scrotum. The data procured from the medical records included demographic characteristics, clinical and sonographic findings, and the final diagnosis. Results: The final diagnoses among a cohort of 86 pediatric males (average age 6 ± 3.9 years) with acute scrotum were as follows: epididymal and testicular appendix torsion (44.7% and 17.6%, respectively), testicular torsion (15.3%), trauma and hematoma (5.9%), incarcerated hernia (4.7%), idiopathic scrotal edema (4.7%), epididymitis (4.7%), and Henoch-Schonlein purpura (3.5%). The heterogeneous testicular appearance in patients with testicular torsion was significantly compared with the appendix torsion. The increased testicle size noted on the sonogram favored the diagnosis of testicular torsion. In cases of testicular torsion, the vascular flow was reduced or absent, although it was normal or increased in appendix torsion. Increased epididymal vascular flow was more common in cases of appendix torsion. Conclusion: Based on the diagnostic findings in this cohort, the following were the most common and accurate sonographic findings in distinguishing the causes of a pediatric acute scrotum: an epididymis enlargement coexisting with a small adjacent avascular mass, due to the torsion of intra-scrotal appendages and a mass shape of the epididymis.
Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations
Authors: Döhner Hartmut , DiNardo Courtney D. , Appelbaum Frederick R. , Craddock Charles , Dombret Hervé , Ebert Benjamin L. , Fenaux Pierre , Godley Lucy A. , Hasserjian Robert P. , Larson Richard A. , Levine Ross L. , Miyazaki Yasushi , Niederwieser Dietger , Ossenkoppele Gert , Röllig Christoph , Sierra Jorge , Stein Eytan M. , Tallman Martin S. , Tien Hwei-Fang , Wang Jianxiang , Wierzbowska Agnieszka , Wei Andrew H. , Löwenberg Bob 
Published: August 2024

AbstractThe European LeukemiaNet (ELN) genetic risk classifications were developed based on data from younger adults receiving intensive chemotherapy. Emerging analyses from patients receiving less-intensive therapies prompted a proposal for an ELN genetic risk classification specifically for this patient population.
Unbalanced MYC break-apart FISH patterns indicate the presence of a MYC rearrangement in HGBCL-DH-BCL2
Authors: Collinge Brett , Ben-Neriah Susana , Hilton Laura K. , Alduaij Waleed , Tucker Tracy , Slack Graham W. , Farinha Pedro , Craig Jeffrey W. , Boyle Merrill , Meissner Barbara , Villa Diego , Gerrie Alina S. , Sehn Laurie H. , Savage Kerry J. , Morin Ryan D. , Mungall Andrew J. , Steidl Christian , Scott David W. 
Published: August 2024

Abstract
Fluorescence in situ hybridization (FISH) using break-apart probes is recommended for identifying high-grade B-cell lymphoma with MYC and BCL2 rearrangements (HGBCL-DH-BCL2). Unbalanced MYC break-apart patterns, in which the red or green signal is lost, are commonly reported as an equivocal result by clinical laboratories. In a cohort of 297 HGBCL-DH-BCL2, 13% of tumors had unbalanced MYC break-apart patterns with loss of red (LR; 2%) or loss of green (LG; 11%) signal. To determine the significance of these patterns, MYC rearrangements were characterized by sequencing in 130 HGBCL-DH-BCL2, including 3 LR and 14 LG tumors. A MYC rearrangement was identified for 71% of tumors with LR or LG patterns, with the majority involving immunoglobulin loci or other recurrent MYC rearrangement partners. The architecture of these rearrangements consistently preserved the rearranged MYC allele, with the MYC gene predicted to be on the derivative chromosome containing the signal that is still present in nearly all cases. MYC protein expression, MYC messenger RNA expression, and the proportion of tumors expressing the dark-zone signature was not significantly different between balanced and unbalanced groups. These results support a recommendation that unbalanced MYC break-apart FISH patterns be reported as positive for MYC rearrangement in the context of diagnosing HGBCL-DH-BCL2.
Unusual testicular metastatic localization of Ewing’s sarcoma: case report
Authors: Aboulaich Youness , Kharbach Youssef , Khallouk Abdelhak 
Published: August 2024

Abstract
Background
Ewing’s sarcoma is a rare form of bone cancer that can also affect soft tissues. In some cases, it can spread to other parts of the body, including the testicles, causing testicular metastases. To our knowledge, no testicular metastasis of Ewing’s sarcoma has been reported in the literature.

Summary
We report an original case of an 18-year-old patient who presented with bilateral testicular masses revealing an exceptional metastasis of metastatic bone Ewing sarcoma under chemotherapy for one year. It was difficult to diagnose synchronous bilateral testicular metastases of Ewing’s sarcoma due to the low frequency of these metastases. However, given the history of metastatic cancer, the data from the clinical examination, and the results of ultrasound, it should be considered and included in the differential diagnosis.

Conclusion
Despite the uncommon occurrence of secondary testicular metastasis, it should be considered in the differential diagnosis when encountering such a clinical presentation.