bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping the terrain: A conceptual schema for a mental health medication support service in community pharmacy
Authors: Scahill Shane , Fowler Jane L , Hattingh H Laetitia , Kelly Fiona , Wheeler Amanda J 
Published: October 2015

Objective: Mental health–related problems pose a serious issue for primary care, and community pharmacy could make a significant contribution, but there is a dearth of information. Methods: This article reports synthesis of the literature on mental health interventions across a range of pharmacy models, and pharmacy services in contexts beyond mental health. To best inform the design of a community pharmacy medication support intervention for mental health consumers, the literature was reported as a conceptual schema and subsequent recommendations for development, implementation and evaluation of the service. A broad conceptualisation was taken in this review. In addition to mental health and community pharmacy literature, policy/initiatives, organisational culture and change management principles, and evaluative processes were reviewed. Key words were selected and literature reviews undertaken using EMBASE, PubMed, CINAHL and Web of Science. Results: Recommendations were made around: medication support intervention design, consumer recruitment, implementation in community pharmacy and evaluation. Surprisingly, there is a scarce literature relating to mental health interventions in community pharmacy. Even so, findings from other pharmacy models and broader medicines management for chronic illness can inform development of a medication support service for mental health consumers. Key learnings include the need to expand medicines management beyond adherence with respect to both intervention design and evaluation. Conclusion: The conceptual framework is grounded in the need for programmes to be embedded within pharmacies that are part of the health system as a whole.
Lumbosacral intraspinal extradural ganglion cyst in a cat
Authors: de Strobel Francesca , Taeymans Olivier , Rosati Marco , Cherubini Giunio B 
Published: October 2015

Case summary A 16-year-old neutered female domestic shorthair cat was referred for chronic history of reluctance to jump, stiffness of the tail and lower back pain. Mild pelvic limb ataxia, reduced perianal reflex and lumbosacral discomfort were present on neurological examination. On magnetic resonance imaging, a well-defined rounded structure of 3 mm in diameter was identified on the right dorsal aspect of the epidural space at L7–S1, causing displacement of the cauda equina. The lesion was hyperintense to spinal cord parenchyma on T2-weighted images and hypointense on T1-weighted images, consistent with a fluid-filled structure. A Lumbosacral dorsal laminectomy was performed. A clear fluid-containing structure was identified between the right L7 nerve root and the cauda equina. Following surgical excision, histopathology confirmed the cystic nature of the lesion and revealed thick disorganised sheaths of fibrocollagenous tissue and flattened mesenchymal cells lining the luminal part of the cyst wall. A diagnosis of intraspinal ganglion cyst was made. The cat recovered uneventfully. Seven months after surgery euthanasia was performed for unrelated reasons; no neurological deficits were present. Relevance and novel information This is the first reported case of intraspinal ganglion cyst in a cat. Intraspinal extradural cysts should be considered among other differential diagnoses for cats with lumbosacral myelopathy/radiculopathy.
High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia
Authors: Lucena-Araujo Antonio R. , Kim Haesook T. , Thomé Carolina , Jacomo Rafael H. , Melo Raul A. , Bittencourt Rosane , Pasquini Ricardo , Pagnano Katia , Glória Ana Beatriz F. , Chauffaille Maria de Lourdes , Athayde Melina , Chiattone Carlos S. , Mito Ingrid , Bendlin Rodrigo , Souza Carmino , Bortolheiro Cristina , Coelho-Silva Juan L. , Schrier Stanley L. , Tallman Martin S. , Grimwade David , Ganser Arnold , Berliner Nancy , Ribeiro Raul C. , Lo-Coco Francesco , Löwenberg Bob , Sanz Miguel A. , Rego Eduardo M. 
Published: October 2015

Key Points
High ΔNp73/TAp73 expression ratio is associated with lower overall survival and higher cumulative incidence of relapse in APL. ΔNp73/TAp73 expression ratio is an independent prognostic marker in APL.
Experiences of ward rounds among in-patients on an acute mental health ward: a qualitative exploration
Authors: Cappleman Reed , Bamford Zandra , Dixon Clare , Thomas Hayley 
Published: October 2015

Aims and methodTo address the gap in qualitative research examining patients' experiences of ward rounds. In-depth interviews were conducted with five in-patients on an acute mental health ward. Data were analysed using thematic analysis.ResultsData were organised into three first-order themes, positioned within an overarching theme relating to patients' perceptions of the use of power and control within ward rounds.Clinical implicationsSystemic factors may make it difficult to facilitate ward rounds in a manner which leaves patients feeling fully empowered or in control, but there are practical measures to address these issues, drawn from participants' accounts.
Impact of lumbar instrumented circumferential fusion on the development of adjacent vertebral compression fracture
Authors: Li Y-C. , Yang S-C. , Chen H-S. , Kao Y-H. , Tu Y-K. 
Published: October 2015

We evaluated the impact of lumbar instrumented circumferential fusion on the development of adjacent level vertebral compression fractures (VCFs). Instrumented posterior lumbar interbody fusion (PLIF) has become a popular procedure for degenerative lumbar spine disease. The immediate rigidity produced by PLIF may cause more stress and lead to greater risk of adjacent VCFs. However, few studies have investigated the relationship between PLIF and the development of subsequent adjacent level VCFs. Between January 2005 and December 2009, a total of 1936 patients were enrolled. Of these 224 patients had a new VCF and the incidence was statistically analysed with other covariants. In total 150 (11.1%) of 1348 patients developed new VCFs with PLIF, with 108 (72%) cases at adjacent segment. Of 588 patients, 74 (12.5%) developed new subsequent VCFs with conventional posterolateral fusion (PLF), with 37 (50%) patients at an adjacent level. Short-segment fusion, female and age older than 65 years also increased the development of new adjacent VCFs in patients undergoing PLIF. In the osteoporotic patient, more rigid fusion and a higher stress gradient after PLIF will cause a higher adjacent VCF rate. Cite this article: Bone Joint J 2015;97-B:1411–16.
Acetabular revision with impaction bone grafting and a cemented polyethylene acetabular component
Authors: te Stroet M. A. J. , Keurentjes J. C. , Rijnen W. H. C. , Gardeniers J. W. M. , Verdonschot N. , Slooff T. J. J. H. , Schreurs B. W. 
Published: October 2015

We present the results of 62 consecutive acetabular revisions using impaction bone grafting and a cemented polyethylene acetabular component in 58 patients (13 men and 45 women) after a mean follow-up of 27 years (25 to 30). All patients were prospectively followed. The mean age at revision was 59.2 years (23 to 82). We performed Kaplan–Meier (KM) analysis and also a Competing Risk (CR) analysis because with long-term follow-up, the presence of a competing event (i.e. death) prevents the occurrence of the endpoint of re-revision. A total of 48 patients (52 hips) had died or had been re-revised at final review in March 2011. None of the deaths were related to the surgery. The mean Harris hip score of the ten surviving hips in ten patients was 76 points (45 to 99). The KM survivorship at 25 years for the endpoint ‘re-revision for any reason’ was 58.0% (95% confidence interval (CI) 38 to 73) and for ‘re-revision for aseptic loosening’ 72.1% (95% CI 51 to 85). With the CR analysis we calculated the KM analysis overestimates the failure rate with respectively 74% and 93% for these endpoints. The current study shows that acetabular impaction bone grafting revisions provide good clinical results at over 25 years. Cite this article: Bone Joint J 2015;97-B:1338–44.
Arthroscopy of the hip for patients with mild to moderate developmental dysplasia of the hip and femoroacetabular impingement
Authors: Fukui K. , Trindade C. A. C. , Briggs K. K. , Philippon M. J. 
Published: October 2015

The purpose of this study was to determine patient-reported outcomes of patients with mild to moderate developmental dysplasia of the hip (DDH) and femoroacetabular impingement (FAI) undergoing arthroscopy of the hip in the treatment of chondrolabral pathology. A total of 28 patients with a centre-edge angle between 15° and 19° were identified from an institutional database. Their mean age was 34 years (18 to 53), with 12 female and 16 male patients. All underwent labral treatment and concomitant correction of FAI. There were nine reoperations, with two patients requiring revision arthroscopy, two requiring periacetabular osteotomy and five needing total hip arthroplasty.Patients who required further major surgery were more likely to be older, male, and to have more severe DDH with a larger alpha angle and decreased joint space.At a mean follow-up of 42 months (24 to 89), the mean modified Harris hip score improved from 59 (20 to 98) to 82 (45 to 100; p < 0.001). The mean Western Ontario and McMaster Universities Osteoarthritis Index score improved from 30 (1 to 61) to 16 (0 to 43; p < 0.001). Median patient satisfaction was 9.0/10 (1 to 10). Patients reported excellent improvement in function following arthroscopy of the hip.This study shows that with proper patient selection, arthroscopy of the hip can be successful in the young patient with mild to moderate DDH and FAI.Cite this article: Bone Joint J 2015;97-B:1316–21.
Hemiarthroplasty for irreparable distal humeral fractures
Authors: Nestorson J. , Ekholm C. , Etzner M. , Adolfsson L. 
Published: October 2015

We report our experience of performing an elbow hemiarthroplasty in the treatment of comminuted distal humeral fractures in the elderly patients. A cohort of 42 patients (three men and 39 women, mean age 72; 56 to 84) were reviewed at a mean of 34.3 months (24 to 61) after surgery. Functional outcome was measured with the Mayo Elbow Performance Score (MEPS) and range of movement. The disabilities of the arm, shoulder and hand questionnaire (DASH) was used as a patient rated evaluation. Complications and ulnar nerve function were recorded. Plain radiographs were obtained to assess prosthetic loosening, olecranon wear and heterotopic bone formation. The mean extension deficit was 23.5° (0° to 60°) and mean flexion was 126.8° (90° to 145°) giving a mean arc of 105.5° (60° to 145°). The mean MEPS was 90 (50 to 100) and a mean DASH score of 20 (0 to 63). Four patients had additional surgery for limited range of movement and one for partial instability. One elbow was revised due to loosening, two patients had sensory ulnar nerve symptoms, and radiographic signs of mild olecranon wear was noted in five patients. Elbow hemiarthroplasty for comminuted intra-articular distal humeral fractures produces reliable medium-term results with functional outcome and complication rates, comparable with open reduction and internal fixation and total elbow arthroplasty. Cite this article: Bone Joint J 2015;97-B:1377–84.
The five-year radiological results of the uncemented Oxford medial compartment knee arthroplasty
Authors: Hooper N. , Snell D. , Hooper G. , Maxwell R. , Frampton C. 
Published: October 2015

This study reports on the first 150 consecutive Oxford cementless unicompartmental knee arthroplasties (UKA) performed in an independent centre (126 patients). All eligible patients had functional scores (Oxford knee score and high activity arthroplasty score) recorded pre-operatively and at two- and five-years of follow-up. Fluoroscopically aligned radiographs were taken at five years and analysed for any evidence of radiolucent lines (RLLs), subsidence or loosening. The mean age of the cohort was 63.6 years (39 to 86) with 81 (53.1%) males. Excellent functional scores were maintained at five years and there were no progressive RLLs demonstrated on radiographs. Two patients underwent revision to a total knee arthroplasty giving a revision rate of 0.23/100 (95% confidence interval 0.03 to 0.84) component years with overall component survivorship of 98.7% at five years. There were a further four patients who underwent further surgery on the same knee, two underwent bearing exchanges for dislocation and two underwent lateral UKAs for disease progression. This was a marked improvement from other UKAs reported in New Zealand Joint Registry data and supports the designing centre’s early results. Cite this article: Bone Joint J 2015;97-B:1358–63.
Age-related differences in the use of total shoulder arthroplasty over time
Authors: Singh J. A. , Ramachandran R. 
Published: October 2015

We assessed the age-related differences in the use of total shoulder arthroplasty (TSA) and outcomes, and associated time-trends using the United States Nationwide Inpatient Sample (NIS) between 1998 and 2010. Age was categorised as < 50, 50 to 64, 65 to 79 and ≥ 80 years. Time-trends in the use of TSA were compared using logistic regression or the Cochran Armitage test. The overall use of TSA increased from 2.96/100 000 in 1998 to 12.68/100 000 in 2010. Significantly lower rates were noted between 2009 and 2010, compared with between 1998 and 2000, for: mortality, 0.1% versus 0.2% (p = 0.004); discharge to an inpatient facility, 13.3% versus 14.5% (p = 0.039), and hospital stay > median, 29.4% versus 51.2% (p < 0.001). The rates of use of TSA/100 000 by age groups, < 50, 50 to 64, 65 to 79 and ≥ 80 years were: 0.32, 4.62, 17.82 and 12.56, respectively in 1998 (p < 0.001); and 0.65, 17.49, 75.27 and 49.05, respectively in 2010 (p < 0.001) with an increasing age-related difference over time (p < 0.001). Across the age categories, there were significant differences in the proportion: discharged to an inpatient facility, 3.2% versus 4.2% versus 14.7% versus 36.5%, respectively in 1998 (p < 0.001) and 1.8% versus 4.3% versus 12.5% versus 35.5%, respectively in 2010 (p < 0.001) and the proportion with hospital stay > median, 39.7% versus 40.2% versus 53% versus 69%, respectively in 1998 (p < 0.001) and 17.2% versus 20.6% versus 28.7% versus 50.7%, respectively in 2010 (p < 0.001). In a nationally representative sample, we noted a time-related increase in the use of TSA and increasing age-related differences in outcomes indicating a changing epidemiology of the use of TSA. Age-related differences in outcomes suggest that attention should focus on groups with the worst outcomes. Cite this article: Bone Joint J 2015;97-B:1385–9.
Evidence-based surgical training in orthopaedics
Authors: Price A. J. , Erturan G. , Akhtar K. , Judge A. , Alvand A. , Rees J. L. 
Published: October 2015

Despite being one of the most common orthopaedic operations, it is still not known how many arthroscopies of the knee must be performed during training in order to develop the skills required to become a Consultant. A total of 54 subjects were divided into five groups according to clinical experience: Novices (n = 10), Junior trainees (n = 10), Registrars (n = 18), Fellows (n = 10) and Consultants (n = 6). After viewing an instructional presentation, each subject performed a simple diagnostic arthroscopy of the knee on a simulator with visualisation and probing of ten anatomical landmarks. Performance was assessed using a validated global rating scale (GRS). Comparisons were made against clinical experience measured by the number of arthroscopies which had been undertaken, and ROC curve analysis was used to determine the number of procedures needed to perform at the level of the Consultants. There were marked differences between the groups. There was significant improvement in performance with increasing experience (p < 0.05). ROC curve analysis identified that approximately 170 procedures were required to achieve the level of skills of a Consultant. We suggest that this approach to identify what represents the level of surgical skills of a Consultant should be used more widely so that standards of training are maintained through the development of an evidenced-based curriculum. Cite this article: Bone Joint J 2015;97-B:1309–15.
Prediction of hip displacement in children with cerebral palsy
Authors: Hermanson M. , Hägglund G. , Riad J. , Rodby-Bousquet E. , Wagner P. 
Published: October 2015

Hip displacement, defined in this study as a migration percentage (MP) of more than 40%, is a common, debilitating complication of cerebral palsy (CP). In this prospective study we analysed the risk of developing hip displacement within five years of the first pelvic radiograph.All children with CP in southern and western Sweden are invited to register in the hip surveillance programme CPUP. Inclusion criteria for the two groups in this study were children from the CPUP database born between 1994 and 2009 with Gross Motor Function Classification System (GMFCS) III to V. Group 1 included children who developed hip displacement, group 2 included children who did not develop hip displacement over a minimum follow-up of five years. A total of 145 children were included with a mean age at their initial pelvic radiograph of 3.5 years (0.6 to 9.7).The odds ratio for hip displacement was calculated for GMFCS-level, age and initial MP and head-shaft angle. A risk score was constructed with these variables using multiple logistic regression analysis. The predictive ability of the risk score was evaluated using the area under the receiver operating characteristics curve (AUC).All variables had a significant effect on the risk of a MP > 40%. The discriminatory accuracy of the CPUP hip score is high (AUC = 0.87), indicating a high ability to differentiate between high- and low-risk individuals for hip displacement. The CPUP hip score may be useful in deciding on further follow-up and treatment in children with CP.Cite this article: Bone Joint J 2015;97-B:1441–4.
The constraints on day-case total knee arthroplasty: the fastest fast track
Authors: Thienpont E. , Lavand'homme P. , Kehlet H. 
Published: October 2015

Total knee arthroplasty (TKA) is a major orthopaedic intervention. The length of a patient's stay has been progressively reduced with the introduction of enhanced recovery protocols: day-case surgery has become the ultimate challenge.This narrative review shows the potential limitations of day-case TKA. These constraints may be social, linked to patient’s comorbidities, or due to surgery-related adverse events (e.g. pain, post-operative nausea and vomiting, etc.).Using patient stratification, tailored surgical techniques and multimodal opioid-sparing analgesia, day-case TKA might be achievable in a limited group of patients. The younger, male patient without comorbidities and with an excellent social network around him might be a candidate.Demographic changes, effective recovery programmes and less invasive surgical techniques such as unicondylar knee arthroplasty, may increase the size of the group of potential day-case patients.The cost reduction achieved by day-case TKA needs to be balanced against any increase in morbidity and mortality and the cost of advanced follow-up at a distance with new technology. These factors need to be evaluated before adopting this ultimate ‘fast-track’ approach.Cite this article: Bone Joint J 2015;97-B(10 Suppl A):40–4.
Anatomical study of palato-gingival groove in maxillary central incisors
Authors: Neves Felipe Lucas , Silveira Camila Augusto , Faig-Leite Horácio 
Published: October 2015

Palatogingival groove (PGG) is a developmental anomaly affecting mainly the maxillary incisors. PGG incidence, depth, and length are clinically important because it may cause severe and localized periodontitis; and it may divide the root canal resulting in accessory foramina. This study aimedto analyze the presence, shape, length, and depth of the palatogingival groove in maxillary central incisors. 1,668 maxillary central incisors wereused. Each tooth had its root portion inspected in order to verify PGG presence and depth. The found palatogingival grooves were classified according to the system proposed by Gu [5], as follows: Type I (short and superficial), Type II (long and superficial), and Type III (long and deep). All teeth that showed the grooves were radiographed; five teeth had theirroot surface analyzed through Scanning Electron Microscopic (SEM); and four teeth corresponding to each PGG type were sent to obtain histologicalsections and then submitted to microscopic analysis. Of the 1.668 analyzed incisors, 27 (1.61%) showed the palatogingival groove: 8 (29.6%) Type I, 17 (63%) type II, and 2 (7.4%) Type III. Microscopic analysis revealed no communication between PGG and root canal. In conclusion, our results showed that PGG can be clinically and radiographically diagnosed on maxillary central incisors, with the type II being the most common. The professionalsshould be aware of the features of this groove due to its severe clinical consequences. KEYWORDSIncisor; Anatomical variation; Palatogingival groove
INTERAÇÕES MEDICAMENTOSAS POTENCIAIS EM DIABÉTICOS TIPO 2 PARTICIPANTES DE UM PROGRAMA DE EDUCAÇÃO EM SAÚDE
Authors: Lima Rodrigo Fonseca , Machado Alexandre Vaz , Rebelo Fernanda Maciel , Naves Janeth de Oliveira Silva , Lavich Tatiana Ramos , Dullius Jane 
Published: October 2015

Estudo transversal com objetivo de identificar frequência, impacto clínico e fatores associados a Interações Medicamentosas Potenciais (IMP) em portadores de diabetes mellitus tipo 2 (DM2) participantes de um programa de educação em saúde. O estudo envolveu 71 diabéticos e as IMP foram classificadas utilizando a base UpToDate®. Os participantes com e sem IMP foram comparados considerando variáveis sócio-demográficas e clínicas através dos testes qui-quadrado e t student. Foram utilizados 4,6 medicamentos em média e mais de 70% apresentaram alguma IMP (total de 140 interações). Mais de 70% requeriam monitoramento da farmacoterapia e em 6,4% havia necessidade de considerar alteração da prescrição. As IMP aumentaram conforme número de medicamentos prescritos (p<0,001) e não variou quanto ao gênero, idade e tempo de diagnóstico.
Conservative Management of Cardiac Hemangioma for 11 Years
Authors: Gribaa Rym , Slim Mehdi , Neffati Elyes , Boughzela Essia 
Published: October 2015

Cardiac hemangiomas are benign tumors with an unpredictable natural history. Surgical resection is the treatment of choice; however, conservative management can be an alternative in some patients.
We report a case of a left-sided cardiac hemangioma that we managed conservatively for 11 years without obvious major complications in the patient, an adult woman.
Existence results for nonlinear elliptic problems on fractal domains
Authors: Ferrara Massimiliano , Molica Bisci Giovanni , Repovš Dušan 
Published: October 2015

Abstract
Some existence results for a parametric Dirichlet problem defined on the Sierpiński fractal are proved. More precisely, a critical point result for differentiable functionals is
exploited in order to prove the existence of a well-determined open
interval of positive eigenvalues for which the problem admits at
least one non-trivial weak solution.
One-dimensional singular problems involving thep-Laplacian and nonlinearities indefinite in sign
Authors: Kaufmann Uriel , Medri Iván 
Published: October 2015

AbstractLet Ω be a bounded open interval, letp>1${p>1}$andγ>0${\gamma>0}$, and letm:Ω→ℝ${m:\Omega\rightarrow\mathbb{R}}$be a function that may change sign in Ω. In this article we study the existence and nonexistence of positive solutions for one-dimensional singular problems of the form-(|u′|p-2⁢u′)′=m⁢(x)⁢u-γ${-(|u^{\prime}|^{p-2}u^{\prime})^{\prime}=m(x)u^{-\gamma}}$in Ω,u=0${u=0}$on∂⁡Ω${\partial\Omega}$. As a consequence we also derive existence results for other related nonlinearities.