bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior Chamber Air Bubble Dynamics With Decreases in Atmospheric Pressure
Authors: Donner Ruth , Aschauer Julia , Schmidinger Gerald 
Published: July 2024

Purpose:
To evaluate the effect of decreasing barometric pressure on intracameral bubble size and intraocular pressure (IOP) in eyes with varying air fills in the anterior chamber.

Methods:
A total of 36 human donor eyes received 30%, 50%, or 90% anterior chamber air fill. The eyes were subjected to decreases in atmospheric pressure down to 750 hPa, equal to 2400 m in altitude, and were repeatedly imaged using anterior segment OCT while IOP was measured continuously.

Results:
Eyes with 30% air fill initially showed moderate increases in IOP yet rising to an average of 30.83 mm Hg at 850 hPa (mimicking 1400 m altitude) and 42.08 mm Hg at 750 hPa. Eyes with larger air bubbles showed more acute increases in IOP with increases to an average of 47.25 mm Hg in eyes with 50% air fill at 850 hPa and 63.33 mm Hg at 750 hPa. In eyes with 90% air fill in the anterior chamber, IOP readings with an average of 113.42 mm Hg were observed already at 850 hPa, at which point additional pressure reduction was not performed.

Conclusions:
While severe increases in IOP were observed with decreased atmospheric pressure in eyes with large air bubbles in the anterior chamber, small and moderately sized bubbles seem to allow for travel over modest changes in altitude.
A Protocol for Using Point-of-Care Ultrasound as an Adjunct in Pediatric Cardiac Arrest
Authors: Leviter Julie I. , Feick Megan , Riera Antonio , White Lauren J. 
Published: July 2024

Abstract
Pediatric cardiac arrest is a rare but time-critical event that poses significant challenges to health care providers. Initiation of point-of-care ultrasound (POCUS) early in resuscitation can help optimize the location of chest compressions, identify inadequate compressions, evaluate for sonographic pulse, and help direct management. Although several algorithms currently exist to incorporate POCUS into adult cardiac arrest, none, to our knowledge, currently exist for the pediatric population. We propose a novel protocol for POCUS use as an adjunct to existing standard-of-care measures in pediatric cardiac arrest, which we call the Pediatric Ultrasound for Life-Supporting Efforts protocol.
Implementation and Reach of Health Coaching Using Motivational Interviewing to Reduce Cardiovascular Disease Risk in Uninsured Illinois Women
Authors: Zimmermann Kristine , Cui, MS Liyong , Kaur Ravneet , Ford Chloe , Carnahan Leslie R. , Jefferies Pam , Curtis, MPA Phallisha , Khare Manorama M. 
Published: July 2024

Context:
Cardiovascular disease (CVD) is the leading cause of mortality for US women; lack of health insurance contributes to poor control of risk factors and increased mortality. Health coaching including motivational interviewing can support primary and secondary CVD prevention, but among uninsured women, improving health outcomes is dependent on successfully reaching priority populations.

Objective:
We evaluated the implementation and reach of health coaching with motivational interviewing among clients in the Illinois WISEWOMAN Program (IWP), a CVD screening and risk-reduction program for uninsured women aged 40 to 64.

Intervention:
Following CVD screening, motivational interviewing is offered to all IWP clients via four 30-min one-on-one health coaching sessions to offer personalized guidance on setting and achieving health behavior goals.

Setting:
Our analysis included clients from the eight community-based Illinois agencies that implemented IWP from 2019 to 2023.

Design and Measures:
We assessed client demographic and baseline health characteristics among all IWP clients, those who participated in health coaching by attending at least one session, and those who completed health coaching by attending at least three of four sessions. We also assessed health coaching participation and completion by agency and examined agency-specific associations between client characteristics and health coaching participation and completion.

Results:
Among IWP enrollees (n = 3094), 89.7% participated in at least one health coaching session but only 31.4% completed health coaching by attending at least three sessions. Over 90% of IWP clients participated in at least one health coaching session at 4 IWP agencies. Further, over 85% of health coaching participants completed health coaching at four agencies. Across agencies, no client-level characteristics were consistently associated with health coaching participation or completion.

Conclusions:
High motivational interviewing participation rates support its acceptability among uninsured women, but agency-level community-level barriers likely prevent client engagement in multiple sessions. Reducing CVD risk requires working with partner agencies to address barriers to reaching the priority population.
Current State of Neoadjuvant Therapy for Locally Advanced Rectal Cancer
Authors: Noticewala Sonal S. , Das Prajnan 
Published: July 2024

Abstract
In locally advanced rectal cancer, neoadjuvant treatment has evolved from no preoperative treatment to the addition of radiation and systemic therapy and ultimately total neoadjuvant therapy. Total neoadjuvant therapy is the completion of preoperative radiation or chemoradiation and chemotherapy before surgery in order to maximize tumor response and improve survival outcomes. This review summarizes the literature of the neoadjuvant approaches related to locally advanced rectal cancer and highlights the nuances of selecting the appropriate treatment.
Local-Regional Therapy for Oligometastatic Colorectal Cancer
Authors: Miller Sean R. , Chang Daniel T. 
Published: July 2024

AbstractColorectal cancer is one of the most common malignancies in the United States as well as a leading cause of cancer-related death. Upward of 30% of patients ultimately develop metastatic disease, most commonly to the liver and lung. Untreated, patients have poor survival. Historically, patients with oligometastatic disease were treated with resection leading to long-term survival; however, there are many patients who are not surgical candidates. Innovations in thermal ablation, hepatic artery infusions, chemoembolization and radioembolization, and stereotactic ablative radiation have led to an expansion of patients eligible for local therapy. This review examines the evidence behind each modality for the most common locations of oligometastatic colorectal cancer.
Local Therapy for Metastatic Colorectal Cancer
Authors: Dykstra Michael P. , Apisarnthanarax Smith , Poultsides George , Atkins Katelyn M. , Binder David , Olsen Jeffrey , Diaz Dayssy Alexandra , Chang Daniel T. 
Published: July 2024

Abstract
The oligometastatic disease state, defined as a cancer with 5 or fewer sites of metastasis, is a therapeutic opportunity to improve oncologic outcomes. Colorectal cancer (CRC) was among the first for which oligometastatic treatment was used in routine clinical practice, and recent studies have shown potential for improved overall survival with metastasis-directed therapies. As CRC is the third most common cause of cancer death in men and women, improving oncologic outcomes in this population is of paramount importance. The relatively recent identification of this treatment paradigm and paucity of high-quality data have led to heterogeneity in clinical practice. This review will explore perspectives of a panel of surgical and radiation oncologists for complex or controversial cases of metastatic CRC.
The Role of Circulating Tumor DNA for Management of Patients With Rectal Cancer
Authors: Sahin Ibrahim Halil , Yanes Rami , Saridogan Turcin , Holder-Murray Jennifer , Dasari Arvind N. 
Published: July 2024

Abstract
Recently, organ preservation with total neoadjuvant therapy resulted in substantial progress in the management of locally advanced rectal cancer (LARC). The PROSPECT trial showed noninferiority of de-escalation of radiotherapy for patients with low-risk LARC who do not need abdominoperineal resection. Although these escalation and de-escalation approaches offer more personalized therapeutic approaches, the current state of care for patients with rectal cancer is far from individualized management. Circulating tumor DNA (ctDNA) is known to be one of the most powerful prognostic factors for early relapse and has been investigated in several interventional clinical trials to offer more precise treatment algorithms. In this review article, we discuss recent updates from studies examining the role of ctDNA for the prediction of treatment response and recurrence for patients with rectal cancer. We also elaborate on the future potential use of ctDNA in treatment escalation and de-escalation approaches for more personalized therapeutic interventions.
Point/Counterpoint #2
Authors: Rajeev-Kumar Greeshma , Katipally Rohan R. , Li Shen , Shogan Benjamin D. , Olortegui Kinga S. , Chin Janet , Polite Blase N. , Liauw Stanley L. 
Published: July 2024

AbstractLocally advanced rectal cancer has historically been treated with multimodal therapy consisting of radiation therapy, chemotherapy, and total mesorectal excision. However, recent prospective trials and registry studies have demonstrated similar disease outcomes with nonoperative management for patients who experience an excellent clinical response to radiation and chemotherapy. This article reviews data regarding nonoperative management for rectal cancer, and highlights current challenges and limitations in a point-counterpoint format, in the context of two clinical cases.
Impact of Positive Resection Margins on Recurrence and Survival Following Resection and Adjuvant Chemotherapy in Pancreatic Cancer: Results of the PRODIGE 24-CCTG PA-6 Randomized Controlled Trial
Authors: Lambert Aurélien , Salleron Julia , Harlé Alexandre , Biagi James J. , Leroux Agnès , Thomas Jacques , Monard Laure , Cros Jérôme , Marchal Frédéric , Ayav Ahmet , Conroy Thierry 
Published: July 2024

Objective:
This study investigated the correlation between positive resection margins and outcomes in patients with pancreatic ductal adenocarcinoma who underwent surgery and adjuvant chemotherapy according to the pivotal trial PRODIGE 24-CCTG PA-6.

Background:
The primary focus is on elucidating the prognostic significance of specific resection margins, including those associated with the superior-mesenteric vein (SMV), medial, and posterior pancreas.

Methods:
The analysis involved 400 patients across multiple centers in France and Canada. Surgical resection and subsequent adjuvant chemotherapy were core interventions. This study assessed the prognostic impact of resection margins, highlighting the significance of standardized pathology assessments. Additionally, the influence of chemotherapy regimen choice, comparing gemcitabine to mFOLFIRINOX, on the implications of positive resection margins was examined.

Results:
Only three margins, SMV (HR=1.48 95% CI [1.11;1.96], P<.001), medial (HR=1.92 95% CI [1.36;2.73], P<.001) and posterior (HR=1.65 95% CI [1.21;2.24], P=.002), had a significant prognostic impact on disease-free survival and were sufficient compared with the seven recommended margins (Kappa=0.90 95% CI [0.87; 0.94]). R1 status was significant independent prognostic factor for poorer survival in gemcitabine-treasted patients (HR=1.97 95% CI [1.23;3.16], P=.005) but lost its significance with mFOLFIRINOX (HR=1.46 95% CI [0.91;2.35], P=.114).

Conclusions:
All efforts should be made to evaluate the three margins of the highest prognostic value, with the others being secondary. A key finding of this study is the likely effect of mFOLFIRINOX on local invasion in operated patients, which seems to correct the impairment related to margin involvement, probably explaining the improvements in DFS and OS.
Gender stereotypes regarding power and niceness in Japanese children
Authors: Meng Xianwei , Okanda Mako , Kanakogi Yasuhiro , Uragami Moe , Yamamoto Hiroki , Moriguchi Yusuke 
Published: July 2024

Belief in gendered social power imbalance (i.e. males are more powerful than females) leads to undesirable gender disparities, but little is known about the developmental origins of this belief, especially in Eastern cultures. We investigated the development onset of this belief by focusing on 4–7-year-old Japanese children while considering another belief (females are nicer than males) for comparison. In the dyadic context tasks, children saw pairs of animated characters depicting powerful–powerless or kind–unkind postures and judged the characters' gender (boy or girl). Results suggested both ‘nice = female’ and ‘powerful = female’ gender stereotypes in children. In the collective context tasks, children were presented with stories in occupational contexts, including multiple unspecified people and verbal cues, describing more explicitly the powerful and nice traits of the protagonists. The results replicated the ‘nice = female’ gender stereotype. Moreover, early ‘powerful = male’ gender stereotypes were seen in 6-year-old boys but not among girls in general. These findings demonstrate that Japanese children's beliefs regarding gender differences in power vary depending on the context in which male–female interactions are presented. Additionally, the study reveals that signs of the ‘powerful = male’ social power gender stereotype emerge around the age of 6.
A mouse model of cardiac AL amyloidosis unveils mechanisms of tissue accumulation and toxicity of amyloid fibrils
Authors: Martinez-Rivas G , Ayala MV , Bender S , Codo GR , Swiderska K , Lampis A , Pedroza L , Merdanovic M , Sicard P , Pinault E , Richard L , Lavatelli F , Giorgetti S , Canetti D. , Rinsant A , Kaaki S , Ory C , Oblet C , Pollet J , Naser E , Carpinteiro A , Roussel M , Javaugue V , Jaccard A , Bonaud A , Delpy L , Ehrmann M , Bridoux F , Sirac C 
Published: July 2024

ABSTRACTAL amyloidosis is one of the most common types of systemic amyloidosis, caused by the deposition in tissues of fibrillar aggregates of abnormal immunoglobulin (Ig) light chain (LC), leading to organ dysfunction. The most frequent and severe forms affect the kidneys and heart, the latter being associated with a poor prognosis. Despite extensive efforts to decipher the mechanisms of fibril formation and their toxicity, the lack of reliable in vivo models hinders the study of the disease in its physiological context. We developped a transgenic mouse model producing high amounts of a human AL light chain (LC). While mice exceptionnaly develop spontaneous AL amyloidosis and do not exhibit organ toxicity due to the circulating amyloidogenic free LC, a single injection of amyloid fibrils, made up of the variable domain (VL) of the human LC, or soluble VL led to amyloid deposits in the heart, vessels, spleen and, to a lesser extent, in the kidney and other visceral tissues. AL fibrils in mice contain both full length and fragmented LC with a fragmentation pattern highly superposable to that of human AL fibrils from the same LC subgroup (IGLV6-57). They also develop an early cardiac dysfunction closely resembling the human disease with increased NT-proBNP,and activation of pathways involved in the extracellular matrix remodeling and fibrosis. Overall, this transgenic AL model closely reproduces human cardiac AL amyloidosis and shares with humans the biochemical composition of the deposits, arguing for a conserved mechanism of amyloid fibrils formation. It also shows that a partial degradation of the LC is likely required to initiate amyloid fibril formations. This model offers a new avenue for research on AL amyloidosis and fills an important gap for the preclinical evaluation of new therapies.
DREAMER: Exploring Common Mechanisms of Adverse Drug Reactions and Disease Phenotypes through Network-Based Analysis
Authors: Firoozbakht Farzaneh , Elkjaer Maria Louise , Handy Diane E. , Wang Rui-Sheng , Chervontseva Zoe , Rarey Matthias , Loscalzo Joseph , Baumbach Jan , Tsoy Olga 
Published: July 2024

AbstractAdverse drug reactions (ADRs) are a major concern in clinical healthcare, significantly affecting patient safety and drug development. The need for a deeper understanding of ADR mechanisms is crucial for improving drug safety profiles in drug design and drug repurposing. This study introduces DREAMER (Drug adverse REAction Mechanism ExplaineR), a novel network-based method for exploring the mechanisms underlying adverse drug reactions and disease phenotypes at a molecular level by leveraging a comprehensive knowledge graph obtained from various datasets. By considering drugs and diseases that cause similar phenotypes, and investigating their commonalities regarding their impact on specific modules of the protein-protein interaction network, DREAMER can robustly identify protein sets associated with the biological mechanisms underlying ADRs and unravel the causal relationships that contribute to the observed clinical outcomes. Applying DREAMER to 649 ADRs, we identified proteins associated with the mechanism of action for 67 ADRs across multiple organ systems, e.g., ventricular arrhythmia, metabolic acidosis, and interstitial pneumonitis. In particular, DREAMER highlights the importance of GABAergic signaling and proteins of the coagulation pathways for personality disorders and intracranial hemorrhage, respectively. We further demonstrate the application of DREAMER in drug repurposing and propose sotalol (targeting KCNH2), ranolazine (targeting SCN5A, currently under clinical trial), and diltiazem (indicated drug targeting CACNA1C and SCN3A) as candidate drugs to be repurposed for cardiac arrest. In summary, DREAMER effectively detects molecular mechanisms underlying phenotypes emphasizing the importance of network-based analyses with integrative data for enhancing drug safety and accelerating the discovery of novel therapeutic strategies.
From mandate to co-create: leading the development of inclusive performance evaluation criteria
Authors: Smith Jessi L. , Mendez Sylvia , Poe Jennifer , Johnson Camille , Willson Dale K. , Daniels Elizabeth A. , Song Heather , Skop Emily 
Published: July 2024

PurposeAnnual performance evaluations of faculty are a routine, yet essential, task in higher education. Creating (or revising) performance criteria presents an opportunity for leaders to work with their teams to co-create evaluation metrics that broaden participation and minimise inequity. The purpose of this study was to support organisational leaders in developing equitable performance criteria.Design/methodology/approachWe adopted the “dual-agenda” dialogues training that draws on concepts of collective self-efficacy and intersectionality for department leaders to co-create annual review criteria with their faculty members at one university. We used qualitative and quantitative data to assess the training and conducted an equity audit of the resulting annual review criteria.FindingsSurvey results from faculty members and departmental leaders (n = 166) demonstrated general satisfaction with the process used to create new criteria, perceptions that their criteria were inclusive and optimism about future reviews. Those with greater familiarity with the dialogues process had more positive perceptions of the inclusivity of their department’s criteria and more positive expectations of future reviews. The examination of eight indicators of equity illustrated that the resultant criteria were transparent and holistic.Originality/valueThis study builds on the relatively little research on faculty members’ annual performance evaluations, focussing on inclusive dialogues that centre equity and diversity. Results highlight the value of providing department leaders with evidence-based tools to foster system-level change through equitable evaluation policies. A toolkit is available for adaptation of the “dual-agenda” leadership training to both co-create annual review criteria and improve equity and inclusion.
Deciphering the factors shaping blockchain technology adoption in the BFSI industry: TISM-MICMAC approach
Authors: Himanshu Himanshu , Dhingra Sanjay , Gupta Shelly 
Published: July 2024

Purpose
As the global financial ecosystem grapples with the complexities of modernization, blockchain technology emerges as a pivotal catalyst, offering the banking, financial services, and insurance (BFSI) industry unprecedented opportunities for secured digital transformation and enhanced customer trust. To gain a comprehensive understanding of blockchain technology adoption, this study aims to identify the factors and establish the contextual interrelationships among them.

Design/methodology/approach
The authors have identified the factors affecting blockchain technology adoption in BFSI industry through extensive literature review and experts’ interviews. After identification of factors, contextual relationship has been established based on experts’ opinion and total interpretive structural modeling (TISM) approach. Furthermore, factors are categorized into autonomous, dependent, linkage and driving variables using cross-impact matrix multiplication applied to classification analysis.

Findings
The TISM-based structural model is divided into eight different hierarchal levels in which Government support is placed on the lower most layer (level 8) which indicates that this is the most crucial factor in blockchain adoption. Further social influence and security are placed on seventh and sixth level in the hierarchy.

Practical implications
The results of this study will help the policymakers to direct the resources from the most crucial factor to other factors in the hierarchy as per their relevance. In essence, this study serves as a guiding compass, steering the course of blockchain technology adoption in the BFSI sector toward a more secure and digitally transformed future.

Originality/value
In the current landscape, blockchain technology remains in its nascent stage, leaving ample room for exploration and innovation. This study stands as the pioneering effort to comprehensively identify and establish the contextual relationships among the adoption factors of blockchain technology within BFSI industry. Through rigorous TISM analysis, this paper enriches the existing body of knowledge on blockchain technology adoption.
Determinants of youth financial inclusion in MENA countries: account holding versus the use of digital services
Authors: Berguiga Imène , Adair Philippe 
Published: July 2024

Purpose
Youths aged 15–34 make half the population of Middle East and North Africa (MENA) and over one quarter of the labour force. The purpose of this paper is to address the two following questions. Why youths from Egypt, Jordan and Tunisia lack financial inclusion before (2014 and 2017) and during (2021) the COVID-19 pandemic? What are the determinants of their financial inclusion?

Design/methodology/approach
Financial inclusion encapsulates account holding at financial institutions and the use of digital services they provide. Two probit regressions address financial inclusion regarding these two dimensions, upon three pooled samples selected from the Global Findex Database, each sample gathering roughly 3,000 households including over two-fifths of youths.

Findings
Five results regarding financial inclusion highlight the role of job-status, income, education, gender and age. Prior the pandemic, financial inclusion of young entrepreneurs is affected by (female) gender, (middle) income, (low) education level and country policy. During the pandemic, y women became more financially included; there was no age gap regarding digital services; and despite improvement, digital services remain unsuitable for poorly educated youth. Gender has no effect on the financial inclusion of young employees before and during the pandemic.

Research limitations/implications
Government policy should target youth underserved population to foster financial inclusion, distinguishing voluntary from involuntary reasons of financial exclusion.

Originality/value
To the best of the authors’ knowledge, no paper has addressed yet the determinants of youth financial inclusion, especially the use of digital services, with a focus on job status (entrepreneurs vs employees) in MENA countries, prior and during the pandemic.