bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of NMR Data Completeness on Structure Determinations of Homodimeric Proteins
Authors: Lin Yi‐Jan , Ikeya Teppei , Kirchner Donata K. , Güntert Peter 
Published: August 2014

AbstractThe structure determination of homodimeric proteins by NMR using conventional NOESY experiments is still challenging due to the degeneracy of the chemical shifts in the identical monomers, which causes ambiguity in the NOE assignments. Residues involved in the interface between two monomers provide essential intermolecular NOEs for the structure determinations of homodimeric proteins. Hence NMR data, such as NOE peak lists and chemical shift assignments of these interface residues, play a crucial role for the successful structure determination of homodimeric proteins. This paper extends our previous report (Lin, Y.‐J.; Kirchner, D. K.; Güntert, P. J. Magn. Reson.­ 2012, 222, 96) and investigates the influence of incomplete NOESY peak lists combined with incomplete 1H chemical shift assignments of the interface residues on the structure determination of homodimeric proteins using the program CYANA. Data incompleteness was simulated by random omission of both NOESY cross peaks and interface 1H chemical shifts. Our results for three proteins with different percentages of interface residues reveal that the algorithm can tolerate about 40–50% NOESY peak omission with complete interface chemical shift assignments, which indicates that partial NOESY peak omission does not cause severe problems when the interface chemical shifts are completely assigned. Combining NOESY peak omission with incomplete interface chemical shift assignments, the tolerance for interface chemical shift omission decreases with the extent of omitted NOESY peaks. The tolerance for unassigned interface side chain, methyl and aromatic chemical shifts is affected more strongly by NOESY peak omission than that for the omission of general interface 1H chemical shifts including the backbone. In general about 10–30% peaks omission is tolerated in conjunction with missing chemical shift assignments. If more NOESY peaks are omitted calculations gradually become unstable and tend not to tolerate any missing interface chemical shifts. A large amount of omitted NOESY peaks, for instance 30% omission in our calculations, could decrease the tolerance for missing aromatic or methyl interface 1H chemical shifts to as few as 2–4 missing chemical shifts, suggesting that complete aromatic and methyl 1H chemical shift assignments are important when the NOESY peak data is significantly incomplete. Finally, for homodimeric proteins with a low percentage of interface residues, our results reveal that the omission of NOESY peaks, even at an extent of only 10%, can result in no tolerance against the omission of interface 1H chemical shifts, suggesting that the completeness of both interface 1H chemical shift assignments and NOESY peaks are important for the successful structure determination of proteins with a small homodimer interface.
Fabrication of Electrochemical Reduced Graphene Oxide Films on Glassy Carbon Electrode by Pulsed Potentiostatic Methods and Its Electrochemical Application
Authors: Wang Yanwei , Wu Yanju , Zhao Chunlei , Wang Fei 
Published: August 2014

AbstractA graphene‐based electrochemical sensing platform for sensitive determination of baicalein was constructed by means of pulsed potentiostatic reduction of graphene oxide (GO) on a glassy carbon electrode (GCE). The resulting electrode (ERGO/GCE) was characterized by cyclic voltammetry (CV) and scanning electron microscopy (SEM). The electrochemical behaviors of baicalein at the ERGO/GCE were investigated in detail by CV, chronoamperometry (CA) and chronocoulometry (CC). The experimental results demonstrated that the ERGO/GCE exhibited excellent response toward the redox of baicalein as evidenced by the significant enhancement of redox peak currents (ip) and the decreased peak‐to‐peak separation (ΔEp) in comparison with a bare GCE. Under the optimum experimental conditions, the reduction peak cureent was proportioanal to the baicalein concentration in the range of 5.0 × 10‐9 ∼ 5.0 × 10‐7 mol L‐1 with the detection limit of 2.0 × 10‐9 mol L‐1. The proposed method was also applied successfully to determine baicalein in spiked human blood serum samples.
Noninvasive, in vivo determination of uterine fibroid thermal conductivity in MRI‐guided high intensity focused ultrasound therapy
Authors: Zhang Jiming , Fischer John , Warner Lizette , Oto Aytekin , Hor Pei‐Herng , Muthupillai Raja 
Published: August 2014

PurposeTo estimate the local thermal conductivity of uterine fibroid in vivo at a high temperature range (60–80°C) typically encountered in magnetic resonance imaging‐guided high‐intensity focused ultrasound (MRgHIFU) surgery. The thermal conductivity of uterine fibroids in vivo is unknown and knowledge about tissue thermal conductivity may aid in effective delivery of thermal energy for ablation.Materials and MethodsAll subjects (nine women) provided written informed consent to participate in this Institutional Review Board‐approved study. A total of 10 fibroids were treated using MRgHIFU surgery with real‐time temperature monitoring during both heating and cooling periods. The local thermal conductivity was determined by analyzing the spatiotemporal spread of temperature during the cooling period.ResultsThe thermal conductivity of MRgHIFU‐treated uterine fibroids was 0.47 ± 0.07 W·m–1·K–1 (range: 0.25∼0.67 W·m–1·K–1) which is slightly lower than the reported value for skeletal muscle at temperatures of <40°C (0.52 to 0.62 W·m–1·K–1).ConclusionIt is possible to estimate the thermal conductivity of uterine fibroids in vivo from the spatiotemporal spread of temperature around the HIFU focus during the cooling period. J. Magn. Reson. Imaging 2015;41:1654–1661. © 2014 Wiley Periodicals, Inc.
Optical response of helix‐free FLC: Continuous gray scale, fastest response, and lowest control voltage
Authors: Andreev Alexander L. , Andreeva Tatiana B. , Kompanets Igor N. , Zalyapin Nikolay V. 
Published: August 2014

AbstractElectro‐optical response of a display cells with novel helix‐free FLC (differently, compensated helix ferroelectric—CHF) is considered. Predominance of the shear viscosity in the soliton mode of FLC director reorientation leads to weakening the temperature dependence of the response time. Increasing the electric field frequency expands this temperature interval, and it is 15°C… 45°C for the frequency about 3 kHz at ±1.5 V in a display cell with FLC viscosity of 0.7 P. Increasing the rotational viscosity up to 1.0 P provides the increase of speed ability due to Maxwell's nature of energy dissipation. The optical response time of 24 µs and light modulation frequency of 7 kHz were achieved at the amplitude of control voltage pulses ±1.5 V.Thus, like NLC based cells, the experimental samples of CHF based display cells at the same (or even lower) value of voltage and electric field tension (1–2 V/µm) show the continuous gray scale and hysteresis‐free modulation characteristic (up to 5 kHz) but can provide 40–50 times (!) higher speed. These break‐through results characterize CHF as the most high‐speed materials for future 3D displays and displays using field sequential color technique, including FLCoS and TFT addressed, as well as displays with new functional properties.
Gender differences in associations of serum ferritin and diabetes, metabolic syndrome, and obesity in the China Health and Nutrition Survey
Authors: Han Ling‐ling , Wang Yu‐xia , Li Jia , Zhang Xiao‐lei , Bian Che , Wang He , Du Shufa , Suo Lin‐na 
Published: August 2014

ScopeThis study examines gender differences in associations of serum ferritin and diabetes, metabolic syndrome (MetS), and obesity in Chinese.Methods and resultsBased on a nationwide, population‐based China Health and Nutrition survey this study included 8564 men and women aged 18 years or older. Anthropometric and fasting blood glucose, insulin, lipids, ferritin, and transferrin data were collected. Ferritin concentrations were higher in men than women (201.55 ± 3.6 versus 80.46 ± 1.64 ng/mL, p < 0.0001). The prevalences of MetS, diabetes, obesity, and overweight were 8.05, 8.97, 4.67, 25.88% among men and 14.23, 6.58, 5.81, 26.82% among women, respectively. Elevated ferritin concentrations were associated with higher body mass index, waist circumference, lipids, insulin, glucose (all p < 0.0001). Serum ferritin concentrations increased gradually with aging among women. The inverted U‐shaped association between serum ferritin and age was observed among men. Elevated concentration of ferritins were significantly related with higher risk of MetS (p < 0.0001), obesity (p = 0.010), overweight (p < 0.0001), and diabetes (p < 0.0001) among men, but not among women.ConclusionThere was a gender difference in associations between ferritin and MetS, obesity, and diabetes in Chinese adults. Further evaluations of the variation in gender on these associations are warranted to understand the mechanisms behind gender differences.
The role of peptides derived from Spirulina maxima in downregulation of FcεRI‐mediated allergic responses
Authors: Vo Thanh‐Sang , Ngo Dai‐Hung , Kang Kyong‐Hwa , Park Sun‐Joo , Kim Se‐Kwon 
Published: August 2014

ScopeSpirulina has been found suitable for use as a bioactive additive. It is an excellent source of protein that can be hydrolyzed into bioactive peptides. Two peptides LDAVNR (P1) and MMLDF (P2) purified from enzymatic hydrolysate of Spirulina maxima have been reported to be effective against early atherosclerotic responses. In this study, the intracellular mechanism involved in the downregulation of these peptides on high‐affinity IgE receptor‐mediated allergic reaction was further investigated.Methods and resultsRBL‐2H3 mast cells were pretreated with P1 or P2 and sensitized with dinitrophenyl‐specific IgE antibody before stimulation of antigen dinitrophenyl‐BSA. It was revealed that P1 and P2 exhibited significant inhibition on mast‐cell degranulation via decreasing histamine release and intracellular Ca2+ elevation. The inhibitory activity of P1 was found due to blockade of calcium‐ and microtubule‐dependent signaling pathways. Meanwhile, the inhibition of P2 was involved in suppression of phospholipase Cγ activation and reactive oxygen species production. Moreover, the suppressive effects of P1 and P2 on generation of IL‐4 were evidenced via depression of nuclear factor‐κB translocation.ConclusionThese findings indicate that peptides P1 and P2 from S. maxima may be promising candidates of antiallergic therapeutics, contributing to development of bioactive food ingredients for amelioration of allergic diseases.
β‐Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats
Authors: Mušinović Hana , Bonet M. Luisa , Granados Nuria , Amengual Jaume , von Lintig Johannes , Ribot Joan , Palou Andreu 
Published: August 2014

ScopeWe studied β‐carotene (BC) absorption and metabolism and compared BC and retinyl palmitate (RE) for their impact on white adipose tissue (WAT) development in suckling rats.Methods and resultsRat pups received daily orally from days 1–20 of life either the vehicle or vitamin A (approx. ×3 that ingested daily from maternal milk) in the form of BC or RE. Intact BC was found in serum and liver of BC‐supplemented rats. Both BC and RE supplementation increased retinoic acid mediated transcriptional responses in intestine (on Isx and Bco1) and the liver (on Cyp26a1 and Cpt1a). In contrast, responses in WAT were dependent on the vitamin A source: WAT of BC‐supplemented rats, like WAT of control rats, was enriched in larger adipocytes with increased adipogenic markers (peroxisome proliferator‐activated receptor γ and downstream genes) and reduced markers of proliferative status (proliferating cell nuclear antigen) compared to WAT of RE‐supplemented rats.ConclusionBC is partly absorbed intact by suckling rats, which resembles the situation in humans and suggests that suckling rats may be an appropriate animal model to study BC uptake, metabolism and biological activity, particularly in infants. Vitamin A supplementation with BC or RE in early life differentially affects WAT and may thus entail different outcomes regarding adiposity programming.
Compact diplexer with slotline resonators for wideband and WLAN applications
Authors: Deng Hong‐wei , Zhao Yong‐jiu , He Ying , Liu Hao , Wang Hong‐li 
Published: August 2014

ABSTRACTIn this article, a compact diplexer is proposed using the U‐shaped slotline resonator (U‐SR) and dual‐mode slotline resonator (DM‐SR) for wideband and WLAN applications. The filter using the U‐SR has three transmission poles in the passband and two transmission zeros near the passband edges. The wide upper‐stopband can be realized for the second mode of the U‐SR is well suppressed. The DM‐SR has two resonant frequencies (odd‐ and even‐modes) in the desired passband. And the odd‐mode resonant frequency can be flexibly controlled by the slotline stub, whereas the even‐mode one is fixed. Due to the main path signal counteraction and source‐load coupling, the filter using the DM‐SR possesses two transmission zeros in the upper‐stopband. The mutual loading effect of two filters can generate new transmission zeros, which are mainly applied to improve the isolation. Compact size can be obtained without extra matching network. A diplexer prototype is designed, and good agreement can be obtained between measured and simulated results. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2480–2484, 2014
Dielectric characterization of various soil types using modified microstrip ring resonators techniques
Authors: Then Yi Lung , You Kok Yeow , Dimon Mohamad Ngasri , Tan Tian Swee , Lee Chia Yew 
Published: August 2014

ABSTRACTIn this article, four nondestructive sensor tool of microstrip ring resonator (MRR) with mean diameter 84.8 mm were developed to determine different soil types based on the dielectric constant, εr′ of respective soil types using frequency‐variation method. The four MRR were designed with different angles of microstrip bends (conventional sensor = 0.98 rad, Sensor A = 1.34 rad, Sensor B = 1.57 rad, and Sensor C = 1.64 rad) at the sides of each corner and each sensor was modeled in resistor‐inductor‐capacitor (RLC)‐lumped element circuit with proper adjustment of capacitances. Seven types of soil samples were placed, respectively, on the MRR holder up to 25 mm. The S‐parameters measurement was made with E5071C vector network analyzer. In this article, the measured dielectric constant using proposed Sensor B has better accuracy with smallest overall uncertainties of 2.14% against commercial dielectric probe HP85070D and 2.43% against coaxial cavity technique while its sensitivity was determined at 0.125 toward the seven soil samples and measurement resolution of 0.849. Both mentioned parameters were the highest as compared to the other three proposed sensors. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2498–2502, 2014
Small‐size triple‐wideband LTE tablet device antenna with a wideband feed structure formed by integrated matching network
Authors: Wong Kin‐Lu , Weng Tseng‐Wei 
Published: August 2014

ABSTRACTA small‐size tablet device antenna with three wide operating bands of 698–960 MHz (low band), 1710–2690 MHz (middle band), and 3400–3800 MHz (high band) for the long term evolution operation is presented. The antenna occupies a small ground clearance of 10 × 30 mm2 and has a thin thickness of 3 mm in the tablet device such as a tablet computer in this study. The antenna comprises three radiating branches (Branch 1, Branch 2, and Branch 3) and a wideband feed structure formed by the integrated matching network. Branch 1 and 2 are connected through a series chip inductor to control the antenna's first two resonant modes to occur in the desired low band and middle band, and Branch 3 generates a resonant mode in the desired high band. The integrated matching network comprises a shunt chip capacitor, a shunt chip inductor, and a series chip capacitor to cause dual‐resonance of the antenna's three resonant modes contributed by the three branches, thereby greatly enhancing the low‐band, middle‐band, and high‐band bandwidths to cover the desired operating bands of 698–960, 1710–2690, and 3400–3800 MHz. Details of the proposed antenna are described. Operating principle of the wideband feed structure formed by the integrated matching circuit is also discussed. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2507–2512, 2014
Hybrid‐cascade coupled‐line phasers for high‐resolution radio‐analog signal processing
Authors: Paradis Thomas , Gupta Shulabh , Zhang Qingfeng , Jiang Li J. , Caloz Christophe 
Published: August 2014

ABSTRACTA hybrid‐cascade (HC) coupled‐line phaser configuration is presented to synthesize enhanced group delay responses for high‐resolution radio‐analog signal processing. Using exact analytical transfer functions, the superiority of HC coupled‐line phasers over conventional transversally cascaded C‐section phasers is demonstrated and verified using full‐wave simulations. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2502–2504, 2014
A multinotched octagonal shaped fractal UWB antenna
Authors: Tripathi Shrivishal , Mohan Akhilesh , Yadav Sandeep 
Published: August 2014

ABSTRACTIn this article, a simple design approach for small ultrawideband (UWB) antenna is presented. The small size and wideband operability is obtained by introducing Minkowski like fractal geometry in the design. It is observed that addition of fractal elements at the edges of octagonal shape leads to wideband phenomena. Furthermore, the insertion of multiple notches in the ground plane improves return loss characteristic in the desired UWB operational bandwidth of 3.1–10.6 GHz. The compact 16.5 × 13.5 mm2 antenna geometry size exhibits nearly omnidirectional radiation pattern, with VSWR < 2 over the entire UWB frequency range. The optimized antenna is fabricated and measured using vector network analyzer. The measured characteristics are in good agreement with the simulated one. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2469–2473, 2014
Trapezoidal ring quad‐band fractal antenna for WLAN/WiMAX applications
Authors: Rajeshkumar V. , Raghavan S. 
Published: August 2014

ABSTRACTA novel multiband loaded trapezoidal ring fractal antenna (TRFA) is proposed for wireless local area network (WLAN) and worldwide interoperability for microwave access (WiMAX) applications. The self‐similarity property is applied to the trapezoidal structure and the fractal geometry is achieved by consecutive iterations. The proposed antenna has a compact size of 30 × 30 × 1.6 mm3. The antenna is fabricated and tested. The fourth iteration of the proposed TRFA covers the 2.4/5.2/5.8 GHz WLAN bands and 2.5/3.5/5.5 GHz WiMAX bands with uniform radiation characteristics and an average gain of 2.20 dBi. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2545–2548, 2014
X‐band CMOS power amplifier with high efficiency for motion detection radar
Authors: Park Jonghoon , Lee Changhyun , Park Changkun 
Published: August 2014

ABSTRACTThis article describes a highly efficient X‐band CMOS power amplifier. To obtain high drain voltage for high power, instead of using the typical cascode structure, we use a common‐source structure with a long channel length transistor. Generally, to enable high operating speed at high frequency, smaller transistor technology is used, but we demonstrate that using large transistor technology is also possible. The proposed power amplifier is designed with transistors of 300‐nm channel length in a common‐source structure using a differential structure of RFCMOS technology. Consequently, the maximum output power is 19 dBm with a power added efficiency of 40.5% at an input power of 5 dBm. This RFCMOS power amplifier includes all matching circuits and biasing circuits, and no external components are required. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2552–2557, 2014
Wideband directive folded semicircular dipole antenna
Authors: Yeo Junho , Lee Jong‐Ig 
Published: August 2014

ABSTRACTA simple method to design a wideband directive antenna using a folded semicircular dipole (FSCD) antenna is presented. A planar semicircular dipole (SCD) antenna consists of two semicircular‐shaped arms with a small gap in between. In the proposed antenna, the two semicircular‐shaped arms are folded along the arm axis. The effects of varying the folding angle on the input reflection coefficient and the broadside gain of the FSCD antenna are investigated. A prototype of the proposed FSCD antenna with a folding angle of 60° is fabricated on an FR4 substrate, and its performance is compared with that of the planar SCD antenna. The measured frequency band of the planar SCD antenna for a voltage standing wave (VSWR) <2 is 0.91–20.0 GHz (182.6%) whereas that of the proposed FSCD antenna for a VSWR <2.3 is 0.99–18.79 GHz (180.0%). Broadside gain of the proposed antenna is above 1.5 dBi with maximum value of 8.1 dBi in the frequency range of 1–12 GHz, whereas broadside gain of the SCD antenna is above 1.5 dBi with maximum value of 3.2 dBi in the frequency range of 1–3.5 GHz. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2513–2516, 2014
Pseudo‐Zernike polynomials for numerically stable PA modeling using 3G+ signals
Authors: Rawat Piyush , Rawat Meenakshi , Boulejfene N. 
Published: August 2014

ABSTRACTThis article presents pseudo‐Zernike polynomials for numerically stable modeling and predistortion of high power amplifiers that, along with lesser coefficient dispersion, is capable of better model stability. Due to inherent properties of proposed basis function, orthogonality property of proposed basis function is independent of any phase rotation, which finds its use in baseband polynomial modeling. Moreover, in contrast to previously proposed orthogonal polynomial models, theoretically, presented model is independent from assumptions of Gaussian or uniform probability density function of the input signal unlike previous models. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2569–2572, 2014
Compact lowpass filter with a sharp roll‐off using patch resonators
Authors: Raphika P. M. , Abdulla P. , Jasmine P. M. 
Published: August 2014

ABSTRACTThis article presents a new compact microstrip lowpass filter with sharp roll‐off and ultrawide stopband using funnel and triangular patch resonators. The patch resonators are placed symmetrically about a high impedance central microstrip line. The filter has been designed and fabricated using a very low cost material. The experimental results show a good agreement with the simulated results and demonstrate that, the sharp roll‐off and good stopband performance is obtained by the proposed filter. The 3 dB cutoff frequency of the proposed filter is at 5.55 GHz with a roll‐off of 84 dB/GHz and its stopband extends up to 11.8 GHz. The filter has an ultra compact size of 9.4 × 8 mm2. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2534–2536, 2014
A smooth evolution scheme to remodulated WDM‐PON based on POLSK/ASK orthogonal modulation
Authors: Qirui Zhou , Hongyan Liu , Jun Ma , Yang Lu , Biao Chen 
Published: August 2014

ABSTRACTA smooth evolution scheme from legacy time division multiplexing passive optical network to the next generation wavelength division multiplexing passive optical network using polarization shift keying/amplitude shift keying orthogonal modulation is proposed and experimentally demonstrated. Clear eye diagrams and bit‐error‐rate performance show crosstalk is small. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2598–2601, 2014