bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrospun, non-woven, nanofibrous membranes prepared from nano-diamond and multi-walled carbon nanotube-filled poly(azo-pyridine) and epoxy composites reinforced with these membranes
Authors: Kausar Ayesha , Ashraf Rozina 
Published: January 2014

We have first prepared non-woven, nanofibrous membranes from nano-diamond (ND) particles and multi-walled carbon nanotube-filled poly(azo-pyridine) by electro-spinning. Then, these membranes were used to obtain epoxy composites reinforced with them. Friedel-Crafts acylation and in situ polymerization were adopted to graft polyamide on multi-walled carbon nanotube (MWCNT) surface to form MWCNT-PA using γ-Phenyl-ɛ-caprolactone. For the preparation of nanofiber, poly(azo-pyridine) (AP) was also synthesized in this work. MWCNT-PA was then electrospun with new AP and ND to yield two types of nanofibers, i.e. MWCNT/AP/PA and ND/MWCNT/AP/PA. Afterward, bisphenol A diglycidyl ether (DGEBA) matrix was reinforced with electrospun nanofiber to form two types of nanocomposites, with and with out ND. Scanning and transmission electron microscopy revealed non-woven nanofibrous membranes of MWCNT/AP/PA/DGEBA and ND/MWCNT/AP/PA/DGEBA. Compared with MWCNT/AP/PA/DGEBA 3 (3 wt.% MWCNT/AP/PA nanofibers) in DGEBA (323.6 MPa), the tensile strength for ND/MWCNT/AP/PA/DGEBA film reinforced with 3 wt.% ND/MWCNT/AP/PA nanofiber (359.4 MPa) was found to increase. Thermal stability of ND/MWCNT/AP/PA nanofiber reinforced epoxy was higher with T10 537–552℃ and Tg 297–302℃ relative to MWCNT/AP/PA/DGEBA system. Inclusion of ND in the system also increased the electrical conductivity of nanofiber web ND/MWCNT/AP/PA/DGEBA composites from 3.8 to 6.2 S cm−1.
Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal
Authors: Zhao Xinghui , Chen Aili , Yan Xiaomei , Zhang Yue , He Fuhong , Hayashi Yoshihiro , Dong Yunzhu , Rao Yalan , Li Bo , Conway Rajeana M. , Maiques-Diaz Alba , Elf Shannon E. , Huang Nuomin , Zuber Johannes , Xiao Zhijian , Tse William , Tenen Daniel G. , Wang Qianfei , Chen Wei , Mulloy James C. , Nimer Stephen D. , Huang Gang 
Published: January 2014

Key Points
MLL oncoproteins downregulate RUNX1/CBFβ by the CXXC domain and flanking region as a critical step in the development of MLL-related leukemias.
Perinucleolar relocalization and nucleolin as crucial events in the transcriptional activation of key genes in mantle cell lymphoma
Authors: Allinne Jeanne , Pichugin Andrei , Iarovaia Olga , Klibi Manel , Barat Ana , Zlotek-Zlotkiewicz Ewa , Markozashvili Diana , Petrova Natalia , Camara-Clayette Valérie , Ioudinkova Elena , Wiels Joëlle , Razin Sergey V. , Ribrag Vincent , Lipinski Marc , Vassetzky Yegor S. 
Published: January 2014

Key Points
We propose a novel oncogenic mechanism linked to the perinucleolar relocalization of chromosomal segments resulting from the translocation. MCL and BL translocations result in new Ccnd1 and c-myc nuclear positioning, respectively, and nucleolin-dependent activation in both cases.
Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease
Authors: Sparkenbaugh Erica M. , Chantrathammachart Pichika , Mickelson Jacqueline , van Ryn Joanne , Hebbel Robert P. , Monroe Dougald M. , Mackman Nigel , Key Nigel S. , Pawlinski Rafal 
Published: January 2014

Key PointsInhibition of FXa or thrombin might be considered to reduce thrombotic complications and vascular inflammation in sickle cell patients. PAR-2 could be a potential target to inhibit vascular pathology associated with sickle cell disease.
B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)–infected patients rarely react with the viral proteins
Authors: Ng Patrick P. , Kuo Chiung-Chi , Wang Stanley , Einav Shirit , Arcaini Luca , Paulli Marco , Portlock Carol S. , Marcotrigiano Joseph , Tarr Alexander , Ball Jonathan , Levy Ronald , Levy Shoshana 
Published: January 2014

Key Points
We tested the hypothesis that B-cell lymphomas arising in HCV-infected patients express B-cell receptors specific to the virus. We analyzed the reactivity of these B-cell receptors with HCV proteins using several experimental approaches, none of which supported the hypothesis.
Gastrointestinal symptoms before and during menses in healthy women
Authors: Bernstein Matthew T , Graff Lesley A , Avery Lisa , Palatnick Carrie , Parnerowski Katie , Targownik Laura E 
Published: January 2014

Abstract

Background
Little is known as to the extent gastrointestinal (GI) complaints are reported by women around menses. We aimed to describe GI symptoms that occurred premenstrually and during menses in healthy women, and to specifically assess the relationship of emotional symptoms to GI symptoms around menses.

Methods
We recruited healthy, premenopausal adult women with no indication of GI, gynecologic, or psychiatric disease who were attending an outpatient gynecology clinic for well-woman care. They completed a survey that queried menstrual histories and the presence of GI and emotional symptoms. We compared the prevalence of primary GI symptoms (abdominal pain, diarrhea, constipation, nausea, vomiting), as well as pelvic pain and bloating, in the 5 days preceding menses and during menses, and assessed whether emotional symptoms or other factors were associated with the occurrence of GI symptoms.

Results
Of 156 respondents, 73% experienced at least one of the primary GI symptoms either pre- or during menses, with abdominal pain (58% pre; 55% during) and diarrhea (24% pre; 28% during) being the most common. Those experiencing any emotional symptoms versus those without were more likely to report multiple (2 or more) primary GI symptoms, both premenstrually (depressed p = 0.006; anxiety p = 0.014) and during menses (depressed p < 0.001; anxiety p = 0.008). Fatigue was also very common (53% pre; 49% during), and was significantly associated with multiple GI symptoms in both menstrual cycle phases (pre p < 0.001; during p = 0.01).

Conclusions
Emotional symptoms occurring in conjunction with GI symptoms are common perimenstrually, and as such may reflect shared underlying processes that intersect brain, gut, and hormonal pathways.
Characteristics of sexual violence against adolescent girls and adult women
Authors: Blake Márcia de Toledo , Drezett Jefferson , Vertamatti Maria Auxiliadora , Adami Fernando , Valenti Vitor E , Paiva Adriana Costa , Viana Joseval Martins , Pedroso Daniela , de Abreu Luiz Carlos 
Published: January 2014

Abstract

Background
Sexual violence is considered a serious violation of human rights which affects mainly young women and adolescents. There is little information about the conditions under which sexual offences occur. We evaluated characteristics of sexual violence against adolescent girls and adult women.

Method
This is a quantitative, retrospective, descriptive study of sexual violence against adolescent girls and adult women. Analyses were carried out on data collected from 1118 women, 546 adolescents (10-19 years) and 572 adults (≥ 20 years), with a complaint of rape treated at Hospital Pérola Byington, São Paulo, between 1994 and 1999. The age limit of the adolescent sample met the World Health Organization’s (WHO) criteria. We analyzed the type of sexual contact, degree of intimidation, perpetrator and activity of the victim during the approach.

Results
Crimes without penetration were five times more frequent in adolescents and use of threats of death or intimidation was common in both groups. Mental illness was more prevalent in adult victims and the majority of adolescent victims were aged <14 years. Uncle and stepfather perpetrators were more frequent among adolescents and partners or former intimate partners in adult women. In most cases the approach occurred in public places, although sex crimes at the perpetrator’s residence were more frequent amongst adolescents.

Conclusions
Although children and adolescents require the same intervention measures and legal protection, a considerable proportion of adolescent sex offenders can face conditions similar to those of adult women.
Mathematical programming with multiple sets split monotone variational inclusion constraints
Authors: Yu Zenn-Tsun , Lin Lai-Jiu , Chuang Chih-Sheng 
Published: January 2014

Abstract
In this paper, we first study a hierarchical problem of Baillon’s type, and we study a strong convergence theorem of this problem. For the special case of this convergence theorem, we obtain a strong convergence theorem for the ergodic theorem of Baillon’s type. Our result of the ergodic theorem of Baillon’s type improves and generalizes many existence theorems of this type of problem. Two numerical examples are given to demonstrate our results.
As applications of our convergence theorem of the hierarchical problem, we study the unique solution for the following problems: mathematical programming with multiply sets split variational inclusion and fixed point set constraints; mathematical programming with multiple sets split variational inequalities and fixed point set constraints; the variational inequality problem with a system of mixed type equilibria and fixed point set constraints; the variational inequality problem with multiple sets split system of mixed type equilibria and fixed point set constraints; mathematical programming with a system of mixed type equilibria and fixed point set constraints. We give iteration processes for these types of problems and establish the strong convergence for the unique solution of these problems. For our special case, our results can be reduced to the following problems: the unique minimal norm solution of the multiply sets split monotonic variational inclusion problems; the minimum norm solutions for the multiple sets split system of mixed type equilibria problem; the minimum norm solution of the system of mixed type equilibria problem. Our results will have many applications in diverse fields of science.
Posttraumatic Stress and Psychological Growth in Children With Cancer: Has the Traumatic Impact of Cancer Been Overestimated?
Authors: Phipps Sean , Klosky James L. , Long Alanna , Hudson Melissa M. , Huang Qinlei , Zhang Hui , Noll Robert B. 
Published: January 2014

Purpose To examine posttraumatic stress disorder and posttraumatic stress symptoms (PTSD/PTSS) in children with cancer using methods that minimize focusing effects and allow for direct comparison to peers without a history of cancer. Patients and Methods Children with cancer (n = 255) stratified by time since diagnosis, and demographically matched peers (n = 101) were assessed for PTSD using structured diagnostic interviews by both child and parent reports, and survey measures of PTSS and psychological benefit/growth by child report. Results Cancer was identified as a traumatic event by 52.6% of children with cancer, declining to 23.8% in those ≥ 5 years from diagnosis. By diagnostic interview, 0.4% of children with cancer met criteria for current PTSD, and 2.8% met lifetime criteria by self-report. By parent report, 1.6% of children with cancer met current criteria and 5.9% met lifetime criteria for PTSD. These rates did not differ from controls (all Ps >.1). PTSS levels were descriptively lower in children with cancer but did not differ from controls when all were referring to their most traumatic event (P = .067). However, when referring specifically to cancer-related events, PTSS in the cancer group were significantly lower than in controls (P = .002). In contrast, perceived growth was significantly higher in the cancer group when referring to cancer (P < .001). Conclusion These findings suggest no evidence of increased PTSD or PTSS in youths with cancer. Although childhood cancer remains a significant and challenging event, these findings highlight the capacity of children to adjust, and even thrive, in the face of such challenge.
Telehealth Personalized Cancer Risk Communication to Motivate Colonoscopy in Relatives of Patients With Colorectal Cancer: The Family CARE Randomized Controlled Trial
Authors: Kinney Anita Y. , Boonyasiriwat Watcharaporn , Walters Scott T. , Pappas Lisa M. , Stroup Antoinette M. , Schwartz Marc D. , Edwards Sandra L. , Rogers Amy , Kohlmann Wendy K. , Boucher Kenneth M. , Vernon Sally W. , Simmons Rebecca G. , Lowery Jan T. , Flores Kristina , Wiggins Charles L. , Hill Deirdre A. , Burt Randall W. , Williams Marc S. , Higginbotham John C. 
Published: January 2014

Purpose The rate of adherence to regular colonoscopy screening in individuals at increased familial risk of colorectal cancer (CRC) is suboptimal, especially among rural and other geographically underserved populations. Remote interventions may overcome geographic and system-level barriers. We compared the efficacy of a telehealth-based personalized risk assessment and communication intervention with a mailed educational brochure for improving colonoscopy screening among at-risk relatives of patients with CRC. Methods Eligible individuals age 30 to 74 years who were not up-to-date with risk-appropriate screening and were not candidates for genetic testing were recruited after contacting patients with CRC or their next of kin in five states. Enrollees were randomly assigned as family units to either an active, personalized intervention that incorporated evidence-based risk communication and behavior change techniques, or a mailed educational brochure. The primary outcome was medically verified colonoscopy within 9 months of the intervention. Results Of the 481 eligible and randomly assigned at-risk relatives, 79.8% completed the outcome assessments within 9 months; 35.4% of those in the personalized intervention group and 15.7% of those in the comparison group obtained a colonoscopy. In an intent-to-treat analysis, the telehealth group was almost three times as likely to get screened as the low-intensity comparison group (odds ratio, 2.83; 95% CI, 1.87 to 4.28; P < .001). Persons residing in rural areas and those with lower incomes benefitted at the same level as did urban residents. Conclusion Remote personalized interventions that consider family history and incorporate evidence-based risk communication and behavior change strategies may promote risk-appropriate screening in close relatives of patients with CRC.
Updated Prognostic Model for Predicting Overall Survival in First-Line Chemotherapy for Patients With Metastatic Castration-Resistant Prostate Cancer
Authors: Halabi Susan , Lin Chen-Yen , Kelly W. Kevin , Fizazi Karim S. , Moul Judd W. , Kaplan Ellen B. , Morris Michael J. , Small Eric J. 
Published: January 2014

Purpose Prognostic models for overall survival (OS) for patients with metastatic castration-resistant prostate cancer (mCRPC) are dated and do not reflect significant advances in treatment options available for these patients. This work developed and validated an updated prognostic model to predict OS in patients receiving first-line chemotherapy. Methods Data from a phase III trial of 1,050 patients with mCRPC were used (Cancer and Leukemia Group B CALGB-90401 [Alliance]). The data were randomly split into training and testing sets. A separate phase III trial served as an independent validation set. Adaptive least absolute shrinkage and selection operator selected eight factors prognostic for OS. A predictive score was computed from the regression coefficients and used to classify patients into low- and high-risk groups. The model was assessed for its predictive accuracy using the time-dependent area under the curve (tAUC). Results The model included Eastern Cooperative Oncology Group performance status, disease site, lactate dehydrogenase, opioid analgesic use, albumin, hemoglobin, prostate-specific antigen, and alkaline phosphatase. Median OS values in the high- and low-risk groups, respectively, in the testing set were 17 and 30 months (hazard ratio [HR], 2.2; P < .001); in the validation set they were 14 and 26 months (HR, 2.9; P < .001). The tAUCs were 0.73 (95% CI, 0.70 to 0.73) and 0.76 (95% CI, 0.72 to 0.76) in the testing and validation sets, respectively. Conclusion An updated prognostic model for OS in patients with mCRPC receiving first-line chemotherapy was developed and validated on an external set. This model can be used to predict OS, as well as to better select patients to participate in trials on the basis of their prognosis.
A case of severe psychosis induced by novel recreational drugs
Authors: Dragogna Filippo , Oldani Lucio , Buoli Massimiliano , Altamura A. Carlo 
Published: January 2014

Introduction: The use of novel recreational drugs is becoming of public interest, especially after recent international alerts about their cardiovascular and neurological toxicity. Additionally, little is known about the psychiatric consequences of the long-term use of these compounds.Case presentation: We describe a case of severe psychotic episode likely induced by chronic use of a combination of new recreational drugs (methylenedioxypyrovalerone, mephedrone, butylone and alpha-pyrrolidinopentiophenone). The patient had no psychiatric history and showed poor response to conventional antipsychotic treatment (haloperidol).Conclusions: This case illustrates the potential negative effects of recreational drugs that cannot be limited to an acute psychotic episode but might determine a condition of prolonged paranoid psychosis. Although the use of these compounds is currently increasing, such molecules might often pass undetected in patients accessing the emergency room, leading to misdiagnosis (e.g. schizophrenic episode) and lack of appropriate treatment.
Case report: congenital dislocation of the radial head –a two-in-one approach
Authors: Karuppal Raju , Marthya Anwar , Raman Rajendran V , Somasundaran Sandhya 
Published: January 2014

Background:Congenital dislocation of the radial head of the elbow is rare. It is genetically transmitted in some cases and is often associated with syndromes, such as Nail-Patella syndrome, antecubital pterygium and ulnar dysplasia. About two thirds are posterior, with the remainder being either anterior (15%) or lateral (15%). The natural history of the condition is that symptoms are relatively benign, with only some limitation of motion and deformity. Treatment either involves early attempts at reconstruction or delayed intervention at skeletal maturity with radial head excision. We evaluated the radiographic and functional results of a two-in-one procedure (radial shortening and open reduction) in the treatment of congenital dislocation of the radial head of an eight year old girl.Objective:To describe a technique for easy reduction and maintenance of normal radiocapitellar joint anatomy in cases of congenital dislocation of the radial head.Method:We have introduced one modification to the Sachar’s method of open reduction by adding radial shortening. This can be described as a ‘two incision approach’ with the first incision for the radial shortening and the second for the open reduction of the radiocapitellar joint. The radial shaft was osteotomised first before we performed the radial head relocation. Then the overlapping part of radial shaft was trimmed. It was stabilized with a transarticular K wire fixation.Results:At one year follow up, the elbow is stable with no valgus or fixed flexion deformity. Supination has increased to 40 degrees from zero degrees. An X-ray showed reformation of the radial head with good congruity of the radiocapitellar joint and correction of the radial bow.Conclusion:As far as the authors are aware, this is the first report of congenital dislocation of the radial head being treated by radial shortening and open reduction of radiocapitellar joint through a two incision approach (two-in-one approach). This paper describes this new technique, which we implemented for easy reduction maintenance of normal radiocapitellar joint anatomy.
Feasibility, Reproducibility, and Clinical Validity of the Pediatric Anxiety Rating Scale—Revised for Fragile X Syndrome
Authors: Russo-Ponsaran Nicole M. , Yesensky Jessica , Hessl David , Berry-Kravis Elizabeth 
Published: January 2014

AbstractFragile X syndrome (FXS) is the most common inherited cause of intellectual disability and the most common known genetic cause of autism. FXS is associated with psychiatric impairments, including anxiety disorders. There is a paucity of well-developed measures to characterize anxiety in FXS. However, such scales are needed to measure therapeutic responses to interventions. The Pediatric Anxiety Rating Scale—Revised (PARS-R) was evaluated in 49 individuals with FXS. Feasibility, reproducibility, and clinical validity were assessed. High inter-rater, test–retest, and cross-site reliability were achieved. PARS-R scores were correlated with parent-report and physician ratings of anxiety, suggesting good clinical validity. Results were similar within gender and age subgroups. The PARS-R is a promising tool for measuring the efficacy of interventions targeting anxiety in FXS.
Effects of Dose Frequency of Early Communication Intervention in Young Children With and Without Down Syndrome
Authors: Yoder Paul , Woynaroski Tiffany , Fey Marc , Warren Steven 
Published: January 2014

Abstract
Children with intellectual disability were randomly assigned to receive Milieu Communication Teaching (MCT) at one 1-hr session per week (low dose frequency, LDF) or five 1-hr sessions per week (high dose frequency, HDF) over 9 months (Fey, Yoder, Warren, & Bredin-Oja, 2013. Non-Down syndrome (NDS) and Down syndrome (DS) subgroups were matched on intelligence, mental age, and chronological age. The NDS group had significantly more growth in spoken vocabulary than the DS group. In the DS subgroup, the HDF group had more spoken vocabulary growth than the LDF group when IQ was controlled. In both etiological subgroups, the HDF group yielded greater vocabulary production outcomes than the LDF group for children who played functionally with a range of objects.
Screening Stringency in the Disability Insurance Program
Authors: Johansson Per , Laun Lisa , Laun Tobias 
Published: January 2014

Abstract
We propose a strategy for assessing how the inflow to the disability insurance program has been governed over time. Using ex-post mortality, we analyze the ex-ante health of individuals entering the program, compared to individuals not entering the program in the same year. Applying this strategy to Sweden, we find large variation in the relative health of new beneficiaries compared to non-beneficiaries over time. Some of the fluctuations correspond well to formal changes to screening stringency. However, we also find large variation in health during periods when no changes to formal eligibility criteria have been pursued.
Strategies to improvise teacher tasking for children suffering from attention deficit hyperactive disorder (ADHD)
Authors: Dilawari Kanchan , Tripathi Nishi 
Published: January 2014

Abstract
This article aimed to review the empirical support for teachers to provide strategies for handling students with attention deficit hyperactivity disorder (ADHD). Three major aspects discussed are the alarming rise of ADHD among students, interrelated issues with teaching students with ADHD, and unleashing strategies for handling these children. Practical implications of the school-based outcome literature were delineated, including the need for the following: (a) technical-support mediated strategies; (b) classroom strategies; (c) activity-based strategies; (d) peer tutoring strategies; and (e) homework strategies. In order to bridge the gap between the empirical literature and actual practices employed in schools, school-based professionals are urged to implement empirically supported strategies through individualized interventions based on assessment data. Through long-term implications of such evidence-based strategies, the deficit characteristics of ADHD can be minimized and the likelihood of school success for these students optimized.