Abstract P1-09-12: Effect of a 12-week supervised physical activity and healthy eating program on body weight, functional capacity and serum biomarkers in survivors of triple-negative breast cancer: A randomized, controlled trial
Authors: Vona-Davis Linda , Abraham Jame , Bonner Daniel , Gilleland Diana , Hobbs Gerald , Kurian Sobha , Yanosik Mary Anne , Swisher Anne 
Published: May 2015

Abstract
Regular physical activity and healthy body composition are important predictors of good outcomes for breast cancer survivors, especially in overweight/obese individuals. However, individualized exercise and healthy eating programs have not focused on lifestyle changes and outcomes among women recovering from triple-negative breast cancer. Our purpose was to examine the associations between baseline levels of inflammatory cytokines and obesity-related adipokines after weight loss, diet and physical activity intervention in survivors of triple-negative breast cancer. We enrolled overweight/obese survivors (average time since diagnosis, 4 years) and randomly assigned them to a 12-week supervised exercise and low-fat diet (n=18) or a usual care group (n=10). The program consisted of supervised exercise 3 times/week, as well as 2 unsupervised sessions per week. The goal of our Get Fit for the Fight® program was to complete 150 min/week of moderate-intensity aerobic exercise. Participants completed a 3-day diet record during baseline testing and the dietitian recommended ways to cut calories from these typical eating patterns. The goal of caloric restriction was to decrease dietary fat in order for the participant to consume 200 kcal/week less. Assessments included aerobic fitness, body composition, and self-reported physical activity, mood and quality of life. Blood cytokines and obesity-related adipokines were also analyzed before and after the intervention period. The intervention group lost an average of 2% body fat compared with the control group (p&lt;0.01). Significant (p&lt;0.05) decreases were seen in the intervention group for body weight, BMI, and all skinfold measures except mid-axillary. Self-reported physical activity and breast-cancer specific quality of life also improved significantly in the intervention group from baseline to 12 weeks, indicating a shift from inactivity toward increasing time spent in moderate physical activity, primarily during weekends. No significant associations were observed between the intervention group and serum levels of inflammatory cytokines. However, BMI was significantly correlated (p&lt;0.05) with serum leptin/adiponectin ratios, an indicator of insulin resistance. These findings indicate that a pragmatic lifestyle intervention with physical activity and healthy eating were consistent with improvements in body composition, functional capacity and quality of life for triple-negative breast cancer survivors. The intervention also evoked favorable changes in blood leptin/adiponectin ratios which are linked to reductions in central adiposity and improved insulin sensitivity.
Citation Format: Linda Vona-Davis, Jame Abraham, Daniel Bonner, Diana Gilleland, Gerald Hobbs, Sobha Kurian, Mary Anne Yanosik, Anne Swisher. Effect of a 12-week supervised physical activity and healthy eating program on body weight, functional capacity and serum biomarkers in survivors of triple-negative breast cancer: A randomized, controlled trial [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P1-09-12.