bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct dynamic connectivity profiles promote enhanced conscious perception of auditory stimuli
Authors: Türker Başak , Manasova Dragana , Béranger Benoît , Naccache Lionel , Sergent Claire , Sitt Jacobo D. 
Published: July 2024

AbstractThe neuroscience of consciousness aims to identify neural markers that distinguish brain dynamics in healthy individuals from those in unconscious conditions. Recent research has revealed that specific brain connectivity patterns correlate with conscious states and diminish with loss of consciousness. However, the contribution of these patterns to shaping conscious processing remains unclear. Our study investigates the functional significance of these neural dynamics by examining their impact on participants’ ability to process external information during wakefulness. Using fMRI recordings during an auditory detection task and rest, we show that ongoing dynamics are underpinned by brain patterns consistent with those identified in previous research. Detection of auditory stimuli at threshold is specifically improved when the connectivity pattern at stimulus presentation corresponds to patterns characteristic of conscious states. Conversely, the occurrence of these conscious state-associated patterns increases after detection, indicating a mutual influence between ongoing brain dynamics and conscious perception. Our findings suggest that certain brain configurations are more favorable to the conscious processing of external stimuli. Targeting these favorable patterns in patients with consciousness disorders may help identify windows of greater receptivity to the external world, guiding personalized treatments.
Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder
Authors: Chao Zenas C. , Komatsu Misako , Matsumoto Madoka , Iijima Kazuki , Nakagaki Keiko , Ichinohe Noritaka 
Published: July 2024

AbstractIn autism spectrum disorder (ASD), atypical sensory experiences are often associated with irregularities in predictive coding, which proposes that the brain creates hierarchical sensory models via a bidirectional process of predictions and prediction errors. However, it remains unclear how these irregularities manifest across different functional hierarchies in the brain. To address this, we study a marmoset model of ASD induced by valproic acid (VPA) treatment. We record high-density electrocorticography (ECoG) during an auditory task with two layers of temporal control, and applied a quantitative model to quantify the integrity of predictive coding across two distinct hierarchies. Our results demonstrate a persistent pattern of sensory hypersensitivity and unstable predictions across two brain hierarchies in VPA-treated animals, and reveal the associated spatio-spectro-temporal neural signatures. Despite the regular occurrence of imprecise predictions in VPA-treated animals, we observe diverse configurations of underestimation or overestimation of sensory regularities within the hierarchies. Our results demonstrate the coexistence of the two primary Bayesian accounts of ASD: overly-precise sensory observations and weak prior beliefs, and offer a potential multi-layered biomarker for ASD, which could enhance our understanding of its diverse symptoms.
A type II phosphatidylinositol-4-kinase coordinates sorting of cargo polarizing by endocytic recycling
Authors: Kourkoulou Anezia , Martzoukou Olga , Fischer Reinhard , Amillis Sotiris 
Published: July 2024

AbstractDepending on their phosphorylation status, derivatives of phosphatidylinositol play important roles in vesicle identity, recognition and intracellular trafficking processes. In eukaryotic cells, phosphatidylinositol-4 phosphate pools generated by specific kinases are key determinants of the conventional secretion pathways. Earlier work in yeast has classified phosphatidylinositol-4 kinases in two types, Stt4p and Pik1p belonging to type III and Lsb6p to type II, with distinct cellular localizations and functions. Eurotiomycetes appear to lack Pik1p homologues. In Aspergillus nidulans, unlike homologues in other fungi, AnLsb6 is associated to late Golgi membranes and when heterologously overexpressed, it compensates for the thermosensitive phenotype in a Saccharomyces cerevisiae pik1 mutant, whereas its depletion leads to disorganization of Golgi-associated PHOSBP-labelled membranes, that tend to aggregate dependent on functional Rab5 GTPases. Evidence provided herein, indicates that the single type II phosphatidylinositol-4 kinase AnLsb6 is the main contributor for decorating secretory vesicles with relevant phosphatidylinositol-phosphate species, which navigate essential cargoes following the route of apical polarization via endocytic recycling.
PUFFFIN: an ultra-bright, customisable, single-plasmid system for labelling cell neighbourhoods
Authors: Lebek Tamina , Malaguti Mattias , Boezio Giulia LM , Zoupi Lida , Briscoe James , Elfick Alistair , Lowell Sally 
Published: July 2024

AbstractCell communication coordinates developmental processes, maintains homeostasis, and contributes to disease. Therefore, understanding the relationship between cells in a shared environment is crucial. Here we introduce Positive Ultra-bright Fluorescent Fusion For Identifying Neighbours (PUFFFIN), a cell neighbour-labelling system based upon secretion and uptake of positively supercharged fluorescent protein s36GFP. We fused s36GFP to mNeonGreen or to a HaloTag, facilitating ultra-bright, sensitive, colour-of-choice labelling. Secretor cells transfer PUFFFIN to neighbours while retaining nuclear mCherry, making identification, isolation, and investigation of live neighbours straightforward. PUFFFIN can be delivered to cells, tissues, or embryos on a customisable single-plasmid construct composed of interchangeable components with the option to incorporate any transgene. This versatility enables the manipulation of cell properties, while simultaneously labelling surrounding cells, in cell culture or in vivo. We use PUFFFIN to ask whether pluripotent cells adjust the pace of differentiation to synchronise with their neighbours during exit from naïve pluripotency. PUFFFIN offers a simple, sensitive, customisable approach to profile non-cell-autonomous responses to natural or induced changes in cell identity or behaviour.
Steroid sulfatase and sulfotransferases in the estrogen and androgen action of gynecological cancers: current status and perspectives
Authors: Rižner Tea Lanišnik , Gjorgoska Marija 
Published: July 2024

Abstract
Sulfatase (STS) and sulfotransferases (SULT) have important role in the biosynthesis and action of steroid hormones. STS catalyzes the hydrolysis of estrone-sulfate (E1-S) and dehydroepiandrosterone-sulfate (DHEA-S), while sulfotransferases catalyze the reverse reaction and require 3-phosphoadenosine-5-phosphosulfate as a sulfate donor. These enzymes control the concentration of active estrogens and androgens in peripheral tissues. Aberant expression of STS and SULT genes has been found in both, benign hormone-dependent diseases and hormone-dependent cancers. The aim of this review is to present the current knowledge on the role of STS and SULT in gynecological cancers, endometrial (EC) and ovarian cancer (OC). EC is the most common and OC the most lethal gynecological cancer. These cancers primarily affect postmenopausal women and therefore rely on the local production of steroid hormones from inactive precursors, either DHEA-S or E1-S. Following cellular uptake by organic anion transporting polypeptides (OATP) or organic anion transporters (OAT), STS and SULT regulate the formation of active estrogens and androgens, thus disturbed balance between STS and SULT can contribute to the onset and progression of cancer. The importance of these enzymes in peripheral estrogen biosynthesis has long been recognized, and this review provides new data on the important role of STS and SULT in the formation and action of androgens, their regulation and inhibition, and their potential as prognostic biomarkers.
The Collaboverse: A Collaborative Data-Sharing and Speech Analysis Platform
Authors: Dvorak Justin D. , Boutsen Frank R. 
Published: July 2024

Purpose:
Collaboration in the field of speech-language pathology occurs across a variety of digital devices and can entail the usage of multiple software tools, systems, file formats, and even programming languages. Unfortunately, gaps between the laboratory, clinic, and classroom can emerge in part because of siloing of data and workflows, as well as the digital divide between users. The purpose of this tutorial is to present the Collaboverse, a web-based collaborative system that unifies these domains, and describe the application of this tool to common tasks in speech-language pathology. In addition, we demonstrate its utility in machine learning (ML) applications.

Method:
This tutorial outlines key concepts in the digital divide, data management, distributed computing, and ML. It introduces the Collaboverse workspace for researchers, clinicians, and educators in speech-language pathology who wish to improve their collaborative network and leverage advanced computation abilities. It also details an ML approach to prosodic analysis.

Conclusions:
The Collaboverse shows promise in narrowing the digital divide and is capable of generating clinically relevant data, specifically in the area of prosody, whose computational complexity has limited widespread analysis in research and clinic alike. In addition, it includes an augmentative and alternative communication app allowing visual, nontextual communication.
Overcoming the knowledge gaps in early‐stage servitization journey: A guide for small and medium enterprises
Authors: Rapaccini Mario , Adrodegari Federico , Pezzotta Giuditta , Saccani Nicola 
Published: July 2024

AbstractAlthough the move to more service‐oriented business can be beneficial even to smaller firms, servitization in SMEs remains a largely unexplored topic. The authors contribute to fill this gap exploring how SMEs can overcome the knowledge gaps of servitization faced by companies in the early‐stages of this journey. By combining systematic literature review and expert panel methodology, the authors identify three knowledge gaps that hinder servitization initiatives in SMEs and propose a set of managerial recommendations to tackle with these gaps. In particular, the authors suggest a structured plan of recommendations, and point out how each stakeholder can contribute to fill the mentioned gaps. The proposed actions are specifically suggested for SMEs and focus on greater engagement of internal and external stakeholders. In addition to contributing to the domain scientific research on servitization, the authors therefore respond to the call for application‐oriented research.
Applying novel self‐supervised learning for early detection of retinopathy of prematurity
Authors: Wang Dongmei , Qiao Wanli , Guo Wei , Cai Yuansong 
Published: July 2024

AbstractRetinopathy of prematurity (ROP) mainly occurs in premature infants with low birth weight, and it is the leading cause of childhood blindness. Early and accurate ROP diagnosis is imperative for appropriate treatment. However, less research concentrates on early‐stage ROP diagnosis based on limited‐labelled images in an imbalanced dataset. To address the dilemma, this study proposed a novel self‐supervised network, MOCO‐MIM, for early ROP grading. The proposed classification network was evaluated on a total of 553 labelled fundus images from 89 preterm infants. The trained network achieved a test accuracy of 98.29% and an AUC score of 97.6% for three stages of grading. The adopted method is verified that the proposed method can be detected early stages of ROP more efficiently and grade the severity more accurately based on limited‐labelled fundus images, which is superior to the existing state‐of‐the‐art methods.
Study on the terahertz domain dielectric relaxation response and mechanism of thermal‐oxidative aged cross‐linked polyethylene
Authors: Wang Mengqi , Wang Shihang , Li Xinyu , Feng Yang , Wang Jingran , Li Shengtao 
Published: July 2024

AbstractTo further study the thermal‐oxidative ageing mechanism of crosslinked polyethylene (XLPE), the terahertz frequency domain dielectric parameters and relaxation phenomena of thermal‐oxidative aged XLPE are analysed using terahertz time domain spectroscopy. It is found that the real part of the terahertz dielectric constant increases with the increase of thermal‐oxidative ageing duration, and the imaginary part shows an overall upward trend. Relaxation of the complex dielectric constant of the aged XLPE samples is obvious. Through the second‐order Cole–Cole equation fitting, it is found that there are two relaxation processes around 0.15 and 1.5 THz, and the relaxation strength gradually increases with the ageing time. To explain this phenomena, microstructure changes and crystallisation behaviours are characterised using Fourier transform infrared spectrum and differential scanning calorimetry, respectively. It is suggested that the two relaxations may be caused by elastic dipole polarisation originating from the angular deflection of polar groups and stretching rotation of hydrogen bond. In addition, by comparing the relaxation strength in different temperatures, the source of the relaxation process is further confirmed.
Safety monitoring method for powerline corridors based on single‐stage detector and visual matching
Authors: Li Jinheng , Zheng Hanbo , Liu Peng , Liang Yanshen , Shuang Feng , Huang Junjie 
Published: July 2024

AbstractEffective monitoring and early warning of overhead power lines are critical for ensuring power supply stability and personnel safety. However, existing methods that rely solely on single vision or light detection and ranging (LiDAR) have limitations such as numerous invalid alarms, hardware equipment constraints, and lack of real‐time monitoring capabilities. This article proposes an intelligent monitoring method for safety distance of the powerline corridor based on heterogeneous sensor information. Firstly, an optimised single‐stage detector is designed to detect safety hazard objects. In the detector, the backbone network and the sample matching strategy are improved; in addition, the learning strategy is adjusted. Next, the pose transformation relationship is obtained through the visual matching of prior LiDAR information and images. The back projection transformation of 2D–3D is achieved according to the relationship. Finally, a monocular camera‐based end‐to‐end distance measurement scheme is proposed by combining 2D object information with coordinate transformation relationships. The scheme is applied to the distance measurements from hazard objects to powerlines. The experimental results show that the optimisation method improves the detection accuracy and reduces the computational complexity of the model. Also, case experiments with continuous frame data verify the effectiveness of the safety distance monitoring scheme.
Update Varizella-Zoster-Impfung
Authors: Prelog Martina 
Published: July 2024

ZusammenfassungDie attenuierte Lebendimpfung gegen Varizellen (Windpocken) hat sich in den letzten 2
Jahrzehnten als effektiv und sicher herausgestellt. Der Schutz vor Erkrankung kann durch die
zweite Varizellen-(VZV)-Impfung auf über 95% mit einer langanhaltenden Wirksamkeit angehoben
werden. Gerade immunsupprimierte oder -defiziente Patienten profitieren von den
individualisierten Impfempfehlungen in Abhängigkeit von der immunologischen Dysregulation und
der pharmakologisch relevanten Immunsuppression. Zur Postexpositionsprophylaxe steht eine
passive Immunisierung mit VZV-Hyperimmunglobulin zur Verfügung. Ein adjuvantierter
rekombinanter Zoster-Impfstoff boostert die VZV-spezifische T-Zell-Immunantwort bei
Erwachsenen und ist allen Erwachsenen mit erhöhtem Zoster-Risiko empfohlen. Obwohl
ursprünglich Skepsis bestand gegen die generelle VZV-Impfempfehlung, zeigen sich nun in der
Zusammenschau der mittlerweile generierten Evidenz eine signifikante Abnahme der
Varizellen-Inzidenzen und ein sehr gutes Sicherheitsprofil hinsichtlich Transmission des
Impfstammes, Durchbruchsinfektionen und Zoster-Reaktivierung.
Wie können Menschen mit einer Hörbehinderung über eine
Hörsystemversorgung hinaus unterstützt werden?
Authors: Geßner Sophie , Fuchs Michael , Pieper Lennart Heinrich , Tretbar Kathleen 
Published: July 2024

Zusammenfassung
Ziel Menschen mit Hörbehinderungen wenden zahlreiche Strategien an, um
Schwierigkeiten im Zusammenhang mit der eigenen Höreinschränkung bewältigen zu
können – dieser Prozess wird als Selbstmanagement bezeichnet. Während die
Förderung von Selbstmanagement in fremdsprachigen Rehabilitationsprogrammen fest
verankert ist, gibt es in Deutschland bisher keinerlei Empfehlungen hierzu.
Deshalb besteht das Ziel dieses systematischen Reviews zunächst darin, einen
Überblick bestehender Selbstmanagement-Interventionen für Menschen mit
Hörbehinderungen zu geben und anschließend Einsatzmöglichkeiten im deutschen
Versorgungssystem anzureißen.
Methodik Eine systematische Literaturrecherche wurde auf PubMed
durchgeführt, um Studien mit entsprechenden Interventionsansätzen zu
identifizieren. Wenn die vordefinierten Einschlusskriterien erfüllt werden
konnten, wurden Informationen zur Publikation, Intervention und Evaluation aus
den einzelnen Studien extrahiert und qualitativ zusammengefasst. Die methodische
Qualität der Studien wurde bewertet.
Ergebnisse Insgesamt konnten 23 Artikel eingeschlossen werden. Die
einzelnen Interventionen verfolgten verschiedenste Ziele, thematisierten ein
breites Spektrum von Inhalten (Informationsvermittlung, Aspekte zur
Kommunikationsverbesserung, psychosoziale, technische oder spezifische Aspekte)
und wurden entweder gruppenbasiert, individuumsbasiert oder selbstangeleitet
implementiert. Im Rahmen der Evaluationen konnten, mit Ausnahme weniger Studien,
positive Interventionseffekte bezüglich des wahrgenommenen Hörhandicaps, des
psychosozialen Wohlbefindens und der Kommunikation der
Interventionsteilnehmer*innen festgestellt werden.
Diskussion Die eingeschlossenen Studien wiesen eine starke Heterogenität
bezüglich der methodischen Qualität, der durchgeführten Intervention und des
Evaluationsdesigns auf. Eine Zusammenfassung der Befunde war deshalb nur
qualitativ möglich. Möglichkeiten der Anpassung bestehender
Interventionsprogramme sowie Chancen und Grenzen einer Implementierung im
deutschen Versorgungssystem sind im Weiteren zu diskutieren.
Schlussfolgerung Insgesamt scheint es sich bei Interventionen zur
Unterstützung des Selbstmanagement um eine gewinnbringende Ergänzung zur
alleinigen technischen Geräteversorgung und -anpassung zu handeln, die auch im
deutschsprachigen Raum weiter forciert werden sollte.
Erkenntnisse aus der Durchführung des Masernschutz-Gesetzes nach den
ersten drei Jahren seit Einführung – Daten aus Darmstadt Dieburg
(Hessen)
Authors: Steul Katrin Simone , Fertig Regina , Heinrich Raphaela , Reisert Roswitha , Krahn Jürgen 
Published: July 2024

Zusammenfassung
Hintergrund Durch die Änderung des Infektionsschutzgesetzes im Sinne des
Masernschutzes vom 1. März 2020 wurden verschiedene Einrichtungsformen zur
Meldung ungeimpfter bzw. nicht-immuner Personen verpflichtet. Das Gesundheitsamt
der Stadt Darmstadt und des Landkreises Darmstadt Dieburg stellte sich die
Frage, wie die gesetzlichen Vorgaben durch die Einrichtungen umgesetzt wurden
und welche Aussagekraft die erhobenen Daten in Bezug auf die jeweilige
Zielgruppe hatten.
Methodik Die Meldungen aus den Einrichtungen und die Rückmeldung der
daraufhin durch das Gesundheitsamt angeschriebenen Betroffenen bzw. deren
Erziehungsberechtigten in den ersten drei Jahren seit Einführung wurden
gesichtet und deskriptiv ausgewertet. Die Datenbasis wurde unterteilt in die
Gruppen (1) betreut in einer Schule, (2) betreut in sonstiger
Kindergemeinschaftseinrichtung, (3) untergebracht in einer kommunalen Unterkunft
für Geflüchtete und (4) Beschäftigte in einer dieser oder in einer medizinischen
Einrichtung (§§23, 33, 36 Infektionsschutzgesetz, IfSG).
Ergebnisse Aus Schulen wurden 1527 Kinder (2,5% aller Schüler:innen) mit
unvollständiger bzw. unbekannter Immunität gegen Masern gemeldet. 70% davon
legten nach dem Anschreiben Unterlagen zur ausreichenden Immunität vor, so dass
auf weniger als 1% (0,76%) Kinder ohne Masernschutz geschlossen werden konnte.
Aus den sonstigen Kindergemeinschaftseinrichtungen wurden 17 Kinder mit
unvollständiger bzw. unbekannter Immunität gegen Masern gemeldet. Aus den
Unterkünften für Geflüchtete wurden insgesamt 3986 Personen gemeldet, wovon 566
(14,2%) nach Anschreiben einen vollständigen Nachweis vorlegten. Aus den
Einrichtungen nach §§23, 33 und 36 wurden insgesamt 17 Beschäftigte mit
unvollständiger bzw. unbekannter Masernimmunität gemeldet. Die Gesamtzahl der
beiden letztgenannten Gruppen in diesem Zeitraum konnte nicht sicher abgeschätzt
werden.
Schlussfolgerung Der Meldepflicht wurde sehr unterschiedlich nachgekommen.
Über den Impfstatus der verschiedenen Personengruppen konnte am ehesten, wenn
auch nur begrenzt, in Bezug auf die Schüler:innen eine Aussage getroffen werden.
Für die übrigen Gruppen konnte keine Aussage getroffen werden, da erstens nicht
sicher von einer umfänglichen Meldung durch die Einrichtungen ausgegangen werden
konnte und zweitens die Grundgesamtheit aller meldepflichtigen Personen in
diesen Bereichen nicht bekannt war.
Inventory of state workers’ compensation laws in the United States: first responder mental health
Authors: Brandt-Rauf Sherry , Davis Andrea L. , Taylor Jennifer A. 
Published: July 2024

AbstractWe conducted a comprehensive review of state workers’ compensation laws in the United States to evaluate the extent to which they support first responders with mental injury. Most state workers’ compensation systems divide mental injuries into categories based on their presumed etiology: physical-mental, mental-physical, and mental-mental. Major differences exist among states as to which workers are eligible. Proving workplace causation can be difficult where no traumatic physical injuries exist. Latency periods, time limits, preexisting health conditions, restrictions as to types of condition covered, and complex chains of causation may make this burden, which falls on the claimant, even more challenging. Only nine (9) states enacted presumption of causation laws for mental health conditions to ease claimants’ burden of proof. This contrasts starkly with presumption laws for chronic and infectious diseases. State decision-makers should create presumptions that mental health conditions in first responders are caused or significantly exacerbated by their stressful workplaces.
Constructing comparable intimate partner violence indicators across the DHS, MICS, and PMA health surveys
Authors: Kristiansen Devon , Luetke Maya , Gunther Matt , King Miriam , Bolgrien Anna , Munir Mehr 
Published: July 2024

AbstractWe construct comparable indicators that measure the prevalence of recent intimate partner violence (IPV) using publicly available, integrated microdata within the IPUMS data collections across many countries. The objective of this work is to increase opportunities for comparative research by leveraging vast quantities of harmonized data. We use consistent and comparable variables that measure domestic violence in international health surveys. The most consistent indicators of domestic violence measure physical, psychological, and sexual IPV in the last 12 months. We imposed a consistent reference period and restricted to a comparable subpopulation where these differed across surveys. Aggregating IPV variables across surveys, without careful attention to question wording and subpopulations, may produce inconsistent measures leading to bias, over- or under-estimation of IPV prevalence, or spurious trends and associations. Using comparable indicators in microdata and studying the level, distribution, and covariates of IPV in multiple settings over time, we can better understand these phenomena and identify effective policy interventions.