bluuebunny/crossref_metadata_2025_split huggingface dataset:
HODGKIN LYMPHOMA IN OLDER PATIENTS: AN ORPHAN DISEASE?
Authors: Thyss Antoine , Saada Esma , Gastaud Lauris , Peyrade Frédéric , Ré Daniel 
Published: July 2014

Hodgkin Lymphoma HL ica be cured in the large majority of younger patients, but prognosis for older patients, especially those with advanced-stage disease, has not improved substantially. The percentage of HL patients aged over 60 ranges between 15% and 35%.A minority of them is enrolled into clinical trials. HL in the elderly have some specificities: more frequent male sex, B-symptoms, advanced stage, sub diaphragmatic presentation, higher percentage of mixed cellularity, up to 50% of advanced cases associated to EBV. Very old age (>70) and comorbidities are factor of further worsening prognosis. Like in younger patients, ABVD is the most used protocol, but treatment outcome remains much inferior with more frequent, severe and sometimes specific toxicities. Few prospective studies with specific protocols are available. The main data have been published by the Italian Lymphoma Group with the VEPEMB schedule and the German Hodgkin Study Group with the PVAG regimen. Recently, the Scotland and Newcastle Lymphoma Study Group published the SHIELD program associating a prospective phase 2 trial with VEPEMB and a prospective registration of others patients. Patients over 60y with early-stage disease received three cycles plus radiotherapy and had 81% of 3-year overall survival (OS).Those with advanced-stage disease received six cycles, with 3-year OS of 66%.The role of geriatric and comorbidity assessment in the treatment’s choice for HL in the elderly is a major challenge. The combination of loss of activities of daily living combined with the age stratification more or less 70y has been shown as a simple and effective survival model. Hopes come from promising new agents like brentuximab-vedotin (BV) a novel antibody-drug conjugate. The use of TEP to adapt the combination of chemotherapy and radiotherapy according to the metabolic response could also be way for prospective studies.
The Effect of Office Politics upon the Implementation and Management of the Job Evaluation Programme: An Analytical View
Authors: Hajji Muhammad Ali EL- 
Published: July 2014

This paper concentrates on the negative office politics and negative ‘office ‘politicians’ by simply identifying their divisive effect in context with the implementation and management of the job evaluation programme within organisations along with the difficulties that this can cause both the programme’s committee or management and the employees whose jobs are to be evaluated. It does this by way of example and not because the former (office politics) is considered an exclusive phenomenon of the latter (job evaluation). From here this paper traces the sources of power for those office ‘politicians’. Simultaneously it suggests counter-measures (prophylactic and remedial) by which both the harm caused by and the virulent effect that can result from such unhealthy office politics in relation to the job evaluation programme can be inhibited or marginalized. The purpose and consequence of these counter-measures are to fortify the programme’s processes and outcomes against the office political ploys and tactics. Our experience of teaching this discipline for more than two decades with a further decade in education and the business sector is the backbone upon which this work is established.
Effects of Discrimination of Expectant Ladies on the Economic Performance of Private Firms within the Kenyan Context
Authors: Ahmed Jaffer Fatma 
Published: July 2014

Gender discrimination is currently highly affecting the economic performance of Indian-owned private firms within the Kenyan context. This form of discrimination is particularly featuring expectant ladies who are already working or are currently trying to gain access into the work environment within private organizations. This kind of discrimination has not only affected the expectant ladies, but it has also hindered economic development within the firms that allow this practice to continue. This is evident by the ladies’ careers being halted because they are expectant and hence considered unable to deliver towards the organizations’ objectives. On the other hand, the organization ends up losing valuable employees who would have played a major role in the growth of such firms. Moreover, when some of the ladies discriminated against are bold enough to go to court, the firm losses a lot of money and their identity in the business world is also tarnished, as they have to compensate the lady who is the victim. Discrimination of ladies on the basis of being expectant has been quietly endured by the victims involved, silently suffering; with very few trying to ensure their rights are protected, as per the Kenyan constitution, under the Employment Act, 2007. Data will be collected using questionnaires, interviews and through research done earlier on Gender discrimination. Research will also involve statistical data that has been analyzed on gender discrimination and review of how the practice is affecting our society over the years.
Effect of Perceived Organizational Politics and Core Self Evaluation on Turnover Intention: A South Asian Perspective
Authors: Javed Mehwish , Abrar Muhammad , Bashir Mohsin , Shabir Milha 
Published: July 2014

Previously a great stream of research is available on perceptions of organizational politics and its harmful aftermaths at workplace. Now a day’s scholarly attention diverts from aftermaths to search out for moderators or mediators that could reduce the harmful effects of POP at workplace outcomes. The purpose current study carries in itself is to explore the combined effects of perception of organizational politics and core self-evaluation on the work outcome of turnover intention. The present research also focuses on the use of a moderator named as core self-evaluation in the relationship of perception of organizational politics and turnover intention. In our study a sample size of 100 respondents were taken from the health sector of 3rd largest city of Pakistan, named Faisalabad, through this study we want to explore the main effects that POP and CSE could have on turnover intention for this purpose self-administered surveys were conducted by using a questionnaire having a number of 27 items in it. In this research we analyzed the data by using SPSS software. As hypothesized, that Perceived organizational politics had a significant positive relationship with turnover intentions but the results for CSE were not significantly support the hypothesis. As hypothesized, negative relationship exists between perception of organizational politics and turnover intention was weaker when core self-evaluation was high.
Decoding the DNA of Employee Job Satisfaction
Authors: Zahoor Saira , Rafiq Sidra , Zia Anam , Rizwan Muhammad 
Published: July 2014

The main purpose of this study is to tell, what employee satisfaction is? Employee satisfaction as a pleasurable or positive emotional state resulting from the appraisal of one’s job or job experience.” A sample of 150 respondents was selected to participate in self-Administered questionnaires from various public and private organizations the survey was conducted in 2013. Convenient sampling was used to collect data. Statistically association of locus of control, pay and promotion with employee satisfaction showed significant result but the relationship of training and development employee empowerment, procedural justice with employee satisfaction is insignificant; furthermore the effect of employee satisfaction on turnover intention, job loyalty and job performance is also significant. We identify that turnover intention contributes more rather than the other variables and it has a significant negative relationship with employee satisfaction. This study helps the organization for understanding about employee satisfaction how to increase the level of employee satisfaction in public or private both sectors.
Antecedents and Consequences of Service Innovation: An Empirical Study of Touring Business in the Southern Part of Thailand
Authors: Rattanawong Walailak , Suwanno Nuttida 
Published: July 2014

The objectives of this study was to investigate the relationships between the antecedents affecting service innovation, namely, entrepreneurial orientation, market orientation, service co-production, information technology adoption, human resource practice, and their relationships with service innovation affecting consequences, which was service performance taking into consideration business environments in selecting strategic factors leading to organizational competitive potential development. The subjects of the study were entrepreneurs and executives of 340 touring businesses in the Southern part of Thailand. The data were collected through structural equation modeling. The results of the study revealed the following. 1) Marketing orientation and human resource practice had positive direct effects on service innovation. 2) Entrepreneurial orientation, service co-production, and information technology adoption had indirect effects on service innovation. 3) Service innovation had positive direct effects on service performance and 4) the goodness of fit of the statistical model fitted well to the evident data.
Customer’s Purchase Intention of Counterfeit Mobile Phones in Pakistan
Authors: Rasheed Arslan , Farhan Muhammad , Zahid Maimoona , Javed Nageen , Rizwan Muhammad 
Published: July 2014

Purchase intention is the willingness of people to buy a certain product. When we evaluate the alternatives, purchase decision is ready to be made by the consumer. Purchase Intention does not result in actual purchase every time .The marketing organization should help consumer to act purchase intention. Variety of ways is used by organization to attain it. Our Purpose of this study is basically to identify the purchase intentions of counterfeit mobile phones by consumers in Pakistan. Four preceding factors influence the consumer’s purchase intentions based counterfeits products. By using self-administered questionnaires we collected data from our 160 respondents. For regression analysis we entered all that data into SPSS and do analysis also. Results of our study show significant relationship of past experience and attitude towards counterfeits on purchase intention. The results show insignificant relationship of low price and easy access on purchase intention, and easy access also shows significant relationship towards attitude towards counterfeits. These factors influence the purchase intention. Our this study is a vital source for the national and international marketers to collect information how different factors effect consumer’s purchase intention.
More Manuscripts by the Beryn Scribe and His Cohort
Authors: Mosser Daniel W. , Mooney Linne R. 
Published: July 2014

Abstract
The Beryn Scribe is the copyist of the unique copy of the Tale of Beryn in Alnwick Castle, Duke of Northumberland MS 455 of the Canterbury Tales. He has been identified as a prolific copyist of the Middle English prose Brut, and he produced single copies of the Prick of Conscience, Chaucer's Parliament of Fowls, and Lydgate's Life of Our Lady. He was recently identified as the hand of the paper section of Princeton University MS 100 (the Helmingham manuscript of the Canterbury Tales). In this article, using paleographical, spelling, and textual evidence, Mosser and Mooney identify him as the copyist of the parchment section of Princeton University MS 100, and also of the “Oxford fragments” of the Canterbury Tales and the Oxford, Bodleian Library MS Rawlinson C.901 copy of the Brut. They also associate this scribe with several other manuscript productions.
“Take it as a tale”:
Authors: Ellison Darryl 
Published: July 2014

Abstract
This article explores the prologue to the “Plowman's Tale,” an apocryphal inclusion to Chaucer's canon that participated in the construction of an expansive, productive, Chaucerian persona characteristic of early print editions of Chaucer's works. By reading this tale as if it really were an authentic part of the Canterbury Tales, this essay recontextualizes Chaucer by placing his authentic works alongside such anonymous inclusions, and argues that we can better understand the uncertain nature of the Tales themselves, and the complex status of their authentic author, by paying closer attention to such apocryphal texts.
Chaucer's Forests, Parks, and Groves
Authors: Howes Laura L. 
Published: July 2014

Abstract
Chaucer represents large woodland areas in his narratives in ways that reflect contemporary English practice in managing forests, parks, and groves. His firsthand knowledge of John of Gaunt's holdings and King Edward III's pleasure grounds and parks, among others, correlates to poetic depictions in the Parlement of Fowls, and in tales told by the Knight, Nun's Priest, Pardoner, Wife of Bath, and Friar. Without discounting literary antecedents and poetic topoi in the creation of Chaucer's woodlands, this essay seeks to highlight Chaucer's lived experience of land use as a significant factor in his poetic representations of late medieval landscapes.
Objectif : commutation de tenure
Authors: LaRose André 
Published: July 2014

L’homme d’affaires et homme politique britannique Edward Ellice (1783-1863) est l’un des rares seigneurs à s’être prévalu du droit de rétrocéder sa seigneurie à la Couronne pour se la faire redonner en franc et commun soccage. Il a ainsi pu vendre les terres non concédées de sa seigneurie de Beauharnois – 40 000 hectares –, ce que les règles du régime seigneurial lui interdisaient de faire. Comment cela a-t-il pu se produire ? C’est ce que l’auteur cherche ici à comprendre, en se penchant sur les aspects politiques de la commutation de tenure, les idées et les calculs d’Ellice et ses démarches pour obtenir la commutation. Il examine ensuite les conséquences de la commutation, s’interroge sur l’effet d’entraînement du geste fait par Ellice et situe finalement Beauharnois dans le contexte des politiques foncières au Bas-Canada.
Next‐Generation Sequencing Fragment Library Construction
Authors: Podnar Jessica , Deiderick Heather , Hunicke‐Smith Scott 
Published: July 2014

AbstractAll current next‐generation sequencing (NGS) platforms and applications require the sequencing library to have specific characteristics: in particular, size, size distribution, and 5′ and 3′ flanking sequences. This unit presents a robust protocol for converting a wide variety of input DNA samples into appropriate NGS libraries and discusses important considerations in experimental design, failure modes, and typical results. Curr. Protoc. Mol. Biol. 107:7.17.1‐7.17.16. © 2014 by John Wiley & Sons, Inc.
Attenuation of Replication Stress–Induced Premature Cellular Senescence to Assess Anti‐Aging Modalities
Authors: Zhao Hong , Darzynkiewicz Zbigniew 
Published: July 2014

AbstractDescribed is an in vitro model of premature senescence in pulmonary adenocarcinoma A549 cells induced by persistent DNA replication stress in response to treatment with the DNA damaging drug mitoxantrone (Mxt). The degree of cellular senescence, based on characteristic changes in cell morphology, is measured by laser scanning cytometry. Specifically, the flattening of cells grown on slides (considered the hallmark of cellular senescence) is measured as the decline in local intensity of DNA‐associated DAPI fluorescence (represented by maximal pixels). This change is paralleled by an increase in nuclear area. Thus, the ratio of mean intensity of maximal pixels to nuclear area provides a very sensitive morphometric biomarker for the degree of senescence. This analysis is combined with immunocytochemical detection of senescence markers, such as overexpression of cyclin kinase inhibitors (e.g., p21WAF1) and phosphorylation of ribosomal protein S6 (rpS6), a key marker associated with aging/senescence that is detected using a phospho‐specific antibody. These biomarker indices are presented in quantitative terms defined as a senescence index (SI), which is the fraction of the marker in test cultures relative to the same marker in exponentially growing control cultures. This system can be used to evaluate the anti‐aging potential of test agents by assessing attenuation of maximal senescence. As an example, the inclusion of berberine, a natural alkaloid with reported anti‐aging properties and a long history of use in traditional Chinese medicine, is shown to markedly attenuate the Mxt‐induced SI and phosphorylation of rpS6. The multivariate analysis of senescence markers by laser scanning cytometry offers a promising tool to explore the potential anti‐aging properties of a variety agents.Curr. Protoc. Cytom. 69:9.47.1‐9.47.10. © 2014 by John Wiley & Sons, Inc.
Sustaining ecosystem services: Overcoming the dilemma posed by local actions and planetary boundaries
Authors: Jonas Matthias , Ometto Jean Pierre , Batistella Mateus , Franklin Oskar , Hall Marianne , Lapola David M. , Moran Emilio F. , Tramberend Sylvia , Queiroz Bernardo Lanza , Schaffartzik Anke , Shvidenko Anatoly , Nilsson Sten B. , Nobre Carlos A. 
Published: July 2014

AbstractResolving challenges related to the sustainability of natural capital and ecosystem services is an urgent issue. No roadmap on reaching sustainability exists; and the kind of sustainable land use required in a world that acknowledges both multiple environmental boundaries and local human well‐being presents a quandary. In this commentary, we argue that a new globally consistent and expandable systems‐analytical framework is needed to guide and facilitate decision making on sustainability from the planetary to the local level, and vice versa. This framework would strive to link a multitude of Earth system processes and targets; it would give preference to systemic insight over data complexity through being highly explicit in spatiotemporal terms. Its strength would lie in its ability to help scientists uncover and explore potential, and even unexpected, interactions between Earth's subsystems with planetary environmental boundaries and socioeconomic constraints coming into play. Equally importantly, such a framework would allow countries such as Brazil, a case study in this commentary, to understand domestic or even local sustainability measures within a global perspective and to optimize them accordingly.
Integrated mathematical modeling of hydrological and hydrodynamic response to rainfall events in rural lowland catchments
Authors: Viero D. P. , Peruzzo P. , Carniello L. , Defina A. 
Published: July 2014

AbstractIn rural lowland catchments, negligible topographic gradients and possible interactions between overland and channel flows complicate efforts to predict flood formation, propagation, and inundation. In this study, we demonstrate that an approach in which a two‐dimensional shallow water model is coupled with a two‐dimensional model for the saturated flow in the topsoil layer can accurately reproduce floods in such a lowland catchment. The topsoil porous layer is treated as a confined aquifer where water ponds on the ground surface and as an unconfined aquifer elsewhere. The model includes infiltration from the ground surface into the topsoil layer and downward percolation out of the topsoil layer. The equations of both surface and subsurface models are suitably averaged over a representative elementary area to yield a subgrid model for the coupled surface‐subsurface flow. Field data collected in two rural lowland catchments in the North‐East of Italy are used to evaluate the model performance. The good agreement between computed and measured discharge at the catchments' outlet and the agreement between predicted and surveyed spatial pattern of inundated areas indicate that the model effectively reproduces overland flow and efficiently accounts for the surface‐subsurface flow interaction and the relevant subsurface processes.
Recent Ice Ages on Mars: The role of radiatively active clouds and cloud microphysics
Authors: Madeleine J.‐B. , Head J. W. , Forget F. , Navarro T. , Millour E. , Spiga A. , Colaïtis A. , Määttänen A. , Montmessin F. , Dickson J. L. 
Published: July 2014

AbstractGlobal climate models (GCMs) have been successfully employed to explain the origin of many glacial deposits on Mars. However, the latitude‐dependent mantle (LDM), a dust‐ice mantling deposit that is thought to represent a recent “Ice Age,” remains poorly explained by GCMs. We reexamine this question by considering the effect of radiatively active water‐ice clouds (RACs) and cloud microphysics. We find that when obliquity is set to 35°, as often occurred in the past 2 million years, warming of the atmosphere and polar caps by clouds modifies the water cycle and leads to the formation of a several centimeter‐thick ice mantle poleward of 30° in each hemisphere during winter. This mantle can be preserved over the summer if increased atmospheric dust content obscures the surface and provides dust nuclei to low‐altitude clouds. We outline a scenario for its deposition and preservation that compares favorably with the characteristics of the LDM.
Indonesian throughflow nutrient fluxes and their potential impact on Indian Ocean productivity
Authors: Ayers Jennifer M. , Strutton Peter G. , Coles Victoria J. , Hood Raleigh R. , Matear Richard J. 
Published: July 2014

AbstractThe Indonesian throughflow (ITF) is a chokepoint in the upper ocean thermohaline circulation, carrying Pacific waters through the strongly mixed Indonesian Seas and into the Indian Ocean. Yet the influence of the ITF on biogeochemical fluxes into the Indian Ocean is largely unknown. This study determines the first depth‐ and time‐resolved nitrate, phosphate, and silicate fluxes at the three main exit passages of the ITF: Lombok Strait, Ombai Strait, and Timor Passage. Nutrient flux as well as its variability with depth and time differs greatly between the passages. We estimate the effective flux of nutrients into the Indian Ocean by accounting for existing nutrients in the basin and find it largest in the upper 300–400 m. This suggests that the majority of ITF nutrient supply to the Indian Ocean is to thermocline waters, where it is likely to support new production and significantly impact Indian Ocean biogeochemical cycling.
Simulated effects of a snow layer on retrieval of CryoSat‐2 sea ice freeboard
Authors: Kwok R. 
Published: July 2014

AbstractThe impact of a snow layer on the location of the tracking point (RP) for ranging to the sea ice surface in CryoSat‐2 synthetic aperture interferometric radar altimeter waveforms is simulated. With a range resolution of ~47 cm, the response of the air‐snow (a‐s) interface broadens the response of the snow‐ice (s‐i) interface and displaces the RP toward the altimeter. This effect is largest when the strengths of their returns are comparable and when snow thicknesses are >20 cm. On the other hand, the RP is displaced away from the altimeter when the reduced propagation speed in the snow layer is not accounted for. This analysis examines the dependence of these competing corrections on snow thickness and the relative scattering strengths of the interfaces and the sensitivity of two different tracking approaches (leading edge and centroid) to these snow parameters. Expected errors depend on a better understanding of the relative scattering strengths of the interfaces and snow layer.