bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Cancer Cells via the Reactive Oxygen Species-Mediated Unfolded Protein Response with a Novel Synthetic Polyphenol Conjugate
Authors: Shin Soon Young , Lee Jong Min , Lee Mi So , Koh Dongsoo , Jung Hyeryoung , Lim Yoongho , Lee Young Han 
Published: June 2014

Abstract
Purpose: The selective killing of tumor cells is an important strategy for cancer therapeutics. The aim of this study was to develop a novel antitumor agent that is safe for normal cells with the ability to selectively target cancer cells.
Experimental Design: On the basis of quantitative structure–activity relationship, we synthesized a novel polyphenol conjugate (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (DPP-23). We evaluated the effect of DPP-23 on proliferation, cell cycle, and apoptosis in various tumor cells. We also assessed molecular targets of DPP-23 using genome-wide expression profiling by DNA microarray and real-time PCR array systems.
Results: DPP-23 effectively inhibited the growth of cancer cells in vitro and in vivo (xenografts in Balb/c nude mice). At a molecular level, DPP-23 targeted the unfolded protein response (UPR) in the endoplasmic reticulum (ER) through the production of reactive oxygen species (ROS) in cancer cells, but not in normal cells, resulting in selective killing of tumor cells via caspase-dependent apoptosis.
Conclusions: The selective generation of ROS in cancer cells could be an attractive strategy for the selective killing of cancer cells, while maintaining negligible cytotoxicity to normal cells. DPP-23 represents a promising novel therapeutic agent for the selective production of ROS in cancer cells. Clin Cancer Res; 20(16); 4302–13. ©2014 AACR.
Circulating CD4+ T Cells That Produce IL4 or IL17 When Stimulated by Melan-A but Not by NY-ESO-1 Have Negative Impacts on Survival of Patients with Stage IV Melanoma
Authors: Zelba Henning , Weide Benjamin , Martens Alexander , Derhovanessian Evelyna , Bailur Jithendra Kini , Kyzirakos Christina , Pflugfelder Annette , Eigentler Thomas K. , Di Giacomo Anna Maria , Maio Michele , Aarntzen Erik H.J.G. , de Vries Jolanda , Sucker Antje , Schadendorf Dirk , Büttner Petra , Garbe Claus , Pawelec Graham 
Published: June 2014

Abstract
Purpose: We initially observed that the presence of circulating NY-ESO-1– and/or Melan-A–specific T cells in patients with stage IV melanoma was significantly associated with prolonged survival. Here, we report the ways in which the phenotypes and functions of these T cells differentially affect survival in patients preselected for NY-ESO-1 and/or Melan-A reactivity.
Experimental Design: We assayed functional antigen-reactive T cells recognizing NY-ESO-1 and/or Melan-A after in vitro stimulation using overlapping peptide pools. After restimulation, we assayed six cytokines simultaneously by intracellular cytokine staining. This allowed us to analyze the functional antigen response of both CD4+ and CD8+ T cells at the single-cell level.
Results: We observed that NY-ESO-1 stimulated mainly CD4+ T cells, whereas Melan-A more often stimulated CD8+ T cells. NY-ESO-1 reactivity was not associated with an additional impact on survival, whether CD4+ T cells, CD8+ T cells, or both types of T cells were responding. In contrast, recognition of Melan-A by CD4+ T cells was associated with reduced survival in our cohort of patients preselected for NY-ESO-1 and/or Melan-A reactivity (that is, in patients with exceptionally long survival). We further observed a negative effect on survival in patients with CD4+ T cells producing IL4 and IL17 upon Melan-A stimulation. Their prognosis was comparable to patients without any Melan-A reactivity.
Conclusions: The nature and prognostic impact of specific T-cell responses is different according to targeted antigen. Independent from phenotype and functional aspects, NY-ESO-1 reactivity is associated with good prognosis. In terms of Melan-A, antigen-specific CD8+ but not CD4+ responses are associated with prolonged survival. Clin Cancer Res; 20(16); 4390–9. ©2014 AACR.
Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial
Authors: Richie John P. , Das Arun , Calcagnotto Ana M. , Sinha Raghu , Neidig Wanda , Liao Jiangang , Lengerich Eugene J. , Berg Arthur , Hartman Terryl J. , Ciccarella Amy , Baker Aaron , Kaag Matthew G. , Goodin Susan , DiPaola Robert S. , El-Bayoumy Karam 
Published: June 2014

Abstract
Epidemiologic and laboratory studies indicate that dietary selenium protects against prostate cancer. Results from clinical trials suggest that selenium-enriched yeast (SY) but not selenomethionine (SeMet) may be effective at reducing prostate cancer risk. Our objectives were to directly compare for the first time the effects of SeMet and SY on prostate cancer relevant biomarkers in men. We performed a randomized double blind, placebo-controlled trial of SY (200 or 285 μg/day) and SeMet (200 μg/day) administered for 9 months in 69 healthy men. Primary endpoints included blood levels of selenium-containing compounds and oxidative stress biomarkers [urine 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin-F2α (8-iso-PGF2α) and blood glutathione (GSH)]. Secondary endpoints included plasma glucose and PSA levels. Compliance was high in all groups (&gt;95%). Plasma selenium levels were increased 93%, 54%, and 86% after 9 months in SeMet and low- and high-dose SY groups, respectively, and returned to baseline levels after a 3-month washout (P &lt; 0.05). Levels of 8-OHdG and 8-iso-PGF2α were decreased 34% and 28%, respectively, after 9 months in the high-dose SY group (P &lt; 0.05). These decreases were greatest in individuals with low baseline plasma levels of selenium (&lt;127 ng/mL). No changes in serum PSA or blood glucose and GSH were observed. Overall, we showed for the first time, reductions in biomarkers of oxidative stress following supplementation with SY but not SeMet in healthy men. These findings suggest that selenium-containing compounds other than SeMet may account for the decrease in oxidative stress. Cancer Prev Res; 7(8); 796–804. ©2014 AACR.
Dons da bruxa e trajetórias wiccanas: narrativas sobre ser e tornar-se uma bruxa moderna
Authors: Osório Andréa 
Published: June 2014

Os praticantes de wicca são em sua maioria mulheres e se designam como bruxa(o)s. Através de entrevistas observou-se uma trajetória religiosa que se inicia no âmbito da religião da família de origem, perpassa religiões estabelecidas no país, como a umbanda e o espiritismo kardecista, até desaguar no universo Nova Era. Ao se identificarem como bruxas, as entrevistadas redesenham seu passado de forma a resgatar eventos nos quais o poder da bruxa é posto em evidência. Algumas identificam este poder em parentas, dando maior legitimidade à “nova” identidade, embora se diga ser bruxa “desde sempre”.
“De Mauss a Claude Lévi-Strauss”, cinquenta anos depois: Por uma ontologia Maori
Authors: Maniglier Patrice 
Published: June 2014

traduzido deMANIGLIER, Patrice. “De Mauss à Claude Lévi-Strauss: cinquante ans après. Pour une on-tologie Maori”. Archives de Philosophie, numéro spécial “Merleau-Ponty”, dir. Etienne Bimbenet et Emmanuel de Saint-Aubert, Tome 69, Cahier 1, Printemps, 2006 (p. 37-56).tradutor Ian PackerMestre em Filosofa (EHESS/França)revisor Nicodème de RenesseDoutorando em Antropologia Social/USP
Múltiplos ordenamentos de realidade: o debate iniciado por Lévy-Bruhl
Authors: Tambiah Stanley 
Published: June 2014

traduzido deTAMBIAH, Stanley. [1990] Magic, Science, Religion and the Scope of Rationality. Cambridge University Press, 2006. Cap. 05. Multiple Orderings of Reality: Te Debate Initiated by Lévy-Bruhl.tradutores Daniel BelikMestre em Antropologia Social pela University of AberdeenStella Zagatto PaternianiMestra em Antropologia Social pela Unicamprevisora Iracema DulleyDoutora pela Universidade de São Paulo
Hospital Variation in Survival After Pediatric In-Hospital Cardiac Arrest
Authors: Jayaram Natalie , Spertus John A. , Nadkarni Vinay , Berg Robert A. , Tang Fengming , Raymond Tia , Guerguerian Anne-Marie , Chan Paul S. 
Published: June 2014

Background—
Although survival after in-hospital cardiac arrest is likely to vary among hospitals caring for children, validated methods to risk-standardize pediatric survival rates across sites do not currently exist.

Methods and Results—
From 2006 to 2010, within the American Heart Association’s Get With the Guidelines-Resuscitation registry for in-hospital cardiac arrest, we identified 1551 cardiac arrests in children (<18 years). Using multivariable hierarchical logistic regression, we developed and validated a model to predict survival to hospital discharge and calculated risk-standardized rates of cardiac arrest survival for hospitals with a minimum of 10 pediatric cardiac arrest cases. A total of 13 patient-level predictors were identified: age, sex, cardiac arrest rhythm, location of arrest, mechanical ventilation, acute nonstroke neurological event, major trauma, hypotension, metabolic or electrolyte abnormalities, renal insufficiency, sepsis, illness category, and need for intravenous vasoactive agents prior to the arrest. The model had good discrimination (C-statistic of 0.71), confirmed by bootstrap validation (validation C-statistic of 0.69). Among 30 hospitals with ≥10 cardiac arrests, unadjusted hospital survival rates varied considerably (median, 37%; interquartile range, 24–42%; range, 0–61%). After risk-standardization, the range of hospital survival rates narrowed (median, 37%; interquartile range, 33–38%; range, 29–48%), but variation in survival persisted.

Conclusions—
Using a national registry, we developed and validated a model to predict survival after in-hospital cardiac arrest in children. After risk-standardization, significant variation in survival rates across hospitals remained. Leveraging these models, future studies can identify best practices at high-performing hospitals to improve survival outcomes for pediatric cardiac arrest.
Prehospital Utility of Rapid Stroke Evaluation Using In-Ambulance Telemedicine
Authors: Wu Tzu-Ching , Nguyen Claude , Ankrom Christy , Yang Julian , Persse David , Vahidy Farhaan , Grotta James C. , Savitz Sean I. 
Published: June 2014

Background and Purpose—
Prehospital evaluation using telemedicine may accelerate acute stroke treatment with tissue-type plasminogen activator. We explored the feasibility and reliability of using telemedicine in the field and ambulance to help evaluate acute stroke patients.

Methods—
Ten unique, scripted stroke scenarios, each conducted 4 times, were portrayed by trained actors retrieved and transported by Houston Fire Department emergency medical technicians to our stroke center. The vascular neurologists performed remote assessments in real time, obtaining clinical data points and National Institutes of Health (NIH) Stroke Scale, using the In-Touch RP-Xpress telemedicine device. Each scripted scenario was recorded for a subsequent evaluation by a second blinded vascular neurologist. Study feasibility was defined by the ability to conduct 80% of the sessions without major technological limitations. Reliability of video interpretation was defined by a 90% concordance between the data derived during the real-time sessions and those from the scripted scenarios.

Results—
In 34 of 40 (85%) scenarios, the teleconsultation was conducted without major technical complication. The absolute agreement for intraclass correlation was 0.997 (95% confidence interval, 0.992–0.999) for the NIH Stroke Scale obtained during the real-time sessions and 0.993 (95% confidence interval, 0.975–0.999) for the recorded sessions. Inter-rater agreement using κ-statistics showed that for live-raters, 10 of 15 items on the NIH Stroke Scale showed excellent agreement and 5 of 15 showed moderate agreement. Matching of real-time assessments occurred for 88% (30/34) of NIH Stroke Scale scores by ±2 points and 96% of the clinical information.

Conclusions—
Mobile telemedicine is reliable and feasible in assessing actors simulating acute stroke in the prehospital setting.
Diagnostic Yield of Pelvic Magnetic Resonance Venography in Patients With Cryptogenic Stroke and Patent Foramen Ovale
Authors: Liberman Ava L. , Daruwalla Vistasp J. , Collins Jeremy D. , Maas Matthew B. , Botelho Marcos Paulo Ferreira , Ayache Jad Bou , Carr James , Ruff Ilana , Bernstein Richard A. , Alberts Marc J. , Prabhakaran Shyam 
Published: June 2014

Background and Purpose—
Paradoxical embolization is frequently posited as a mechanism of ischemic stroke in patients with patent foramen ovale. Several studies have suggested that the deep lower extremity and pelvic veins might be an embolic source in cryptogenic stroke (CS) patients with patent foramen ovale.

Methods—
Consecutive adult patients with ischemic stroke or transient ischemic attack and a patent foramen ovale who underwent pelvic magnetic resonance venography as part of an inpatient diagnostic evaluation were included in this single-center retrospective observational study to determine pelvic and lower extremity (LE) deep venous thrombosis (DVT) prevalence in CS versus non-CS stroke subtypes.

Results—

Of 131 patients who met inclusion criteria, 126 (96.2%) also had LE duplex ultrasound data. DVT prevalence overall was 7.6% (95% confidence interval, 4.1–13.6), pelvic DVT 1.5% (95% confidence interval, 0.1–5.8), and LE DVT 7.1% (95% confidence interval, 3.6–13.2). One patient with a pelvic DVT also had a LE DVT. Comparing patients with CS (n=98) with non-CS subtypes (n=33), there was no significant difference in the prevalence of pelvic DVT (2.1% versus 0%,
P
=1), LE DVT (6.2% versus 10.3%,
P
=0.43), or any DVT (7.2% versus 9.1%,
P
=0.71).

Conclusions—
Among patients with ischemic stroke/transient ischemic attack and patent foramen ovale, the majority of detected DVTs were in LE veins rather than the pelvic veins and did not differ by stroke subtype. The routine inclusion of pelvic magnetic resonance venography in the diagnostic evaluation of CS warrants further prospective investigation.
Reflections on the Penn Discourse TreeBank, Comparable Corpora, and Complementary Annotation
Authors: Prasad Rashmi , Webber Bonnie , Joshi Aravind 
Published: June 2014

The Penn Discourse Treebank (PDTB) was released to the public in 2008. It remains the largest manually annotated corpus of discourse relations to date. Its focus on discourse relations that are either lexically-grounded in explicit discourse connectives or associated with sentential adjacency has not only facilitated its use in language technology and psycholinguistics but also has spawned the annotation of comparable corpora in other languages and genres. Given this situation, this paper has four aims: (1) to provide a comprehensive introduction to the PDTB for those who are unfamiliar with it; (2) to correct some wrong (or perhaps inadvertent) assumptions about the PDTB and its annotation that may have weakened previous results or the performance of decision procedures induced from the data; (3) to explain variations seen in the annotation of comparable resources in other languages and genres, which should allow developers of future comparable resources to recognize whether the variations are relevant to them; and (4) to enumerate and explain relationships between PDTB annotation and complementary annotation of other linguistic phenomena. The paper draws on work done by ourselves and others since the corpus was released.
On the South Caspian Contact Zone: Some Talishi Folk Beliefs
Authors: Asatrian Garnik , Arakelova Victoria 
Published: June 2014

One of the productive approaches to the analysis of the phenomenon of frontier zones, and the South Caspian region in particular, could be the delimitation of local cultural areas— not within administrative borders, but rather by frontier lines defined by such parameters as linguistic and toponymic areas, characteristics of the people’s mentality, specifics of local beliefs, etc. The southern and south-western shores of the Caspian Sea can be defined as a unique cultural landscape, a picturesque world “existing on the frontier lines”. On the marginal level—in folk beliefs, religious lore, etc.—the steadfast local substrate transformed Islam into shapes extraneous to the religious dogma. The South Caspian population, despite the domination of traditional forms of Islam, has preserved multiple elements dating back to the pre-Islamic cultural heritage.
The article discusses some peculiarities of folk beliefs of the Talishis, one of the autochthonous peoples of the area. An essential part of the paper includes attempts of revealing the pre-Islamic background of some characters and phenomena, modified and reinterpreted by Muslim thinking or through folk etymologies.
Effectiveness of complex interventions focused on quality-of-life assessment to improve palliative care patients’ outcomes: A systematic review
Authors: Catania Gianluca , Beccaro Monica , Costantini Massimo , Ugolini Donatella , De Silvestri Annalisa , Bagnasco Annamaria , Sasso Loredana 
Published: June 2014

Background: One of the most crucial palliative care challenges is in determining how patient’ needs are defined and assessed. Assessing quality of life has been defined as a priority in palliative care, and it has become a central concept in palliative care practice. Aim: To determine to what extent interventions focused on measuring quality of life in palliative care practice are effective in improving outcomes in palliative care patients. Design: Systematic review according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and hand searches. Data sources: MEDLINE, CINAHL, EMBASE, PsycINFO, and the Cochrane Library were searched for articles published until June 2012, and through hand searching from references lists of included articles. Only studies that included adult palliative care patients, in any palliative care clinical practice setting of care, and with an experimental, quasi-experimental, or observational analytical study design were eligible for inclusion. All studies were independently reviewed by two investigators who scored them for methodological quality by using the Edwards Method Score. Results: In total, 11 articles (of 8579) incorporating information from 10 studies were included. Only three were randomized controlled trials. The quality of the evidence was found from moderate to low. Given a wide variability among patients’ outcomes, individual effect size (ES) was possible for 6 out of 10 studies, 3 of which found a moderate ES on symptoms (ES = 0.68) and psychological (ES = 0.60) and social (ES = 0.55) dimensions. Conclusion: Effectiveness of interventions focused on quality-of-life assessment is moderate. Additional studies should explore the complexity of the real palliative care world more accurately and understand the effects of independent variables included in complex palliative care interventions.
Individually adapted tube current selection and contrast medium injection protocol of coronary CT angiography based on test bolus parameters: a feasibility study
Authors: Zhu Xiaomei , Shi Zhaofei , Zhu Yinsu , Liu Wangyan , Yang Guanyu , Yu Tongfu , Tang Lijun , Xu Yi 
Published: June 2014

Background Test bolus is mostly used to determine the starting point of a full cardiac scanning with respect to injection of a larger bolus of contrast material. So far there are limited data demonstrating the feasibility of using information obtained from a test bolus to adjust contrast delivery protocols and tube current individually during coronary computed tomography angiography (CCTA). Purpose To evaluate the feasibility of individually adapted tube current selection and contrast injection protocols of CCTA based on test bolus parameters. Material and Methods Test bolus followed by CCTA was performed in 93 patients at 100 kV and in 81 patients at 120 kV, respectively. Simulated attenuation of the descending aorta (SimDA) of CCTA was calculated at a fixed contrast injection rate of 4 mL/s. Univariate and multivariate comparisons were performed to identify associations of SimDA and image noise of CCTA (NoiseCCTA) with test bolus information and patient-related factors including body weight (BW), body mass index (BMI), and body surface area (BSA). Results Compared with BW, BMI, and BSA, SimDA was more closely related to the peak time of left ventricle and peak enhancement of right ventricle obtained from test bolus ( r = 0.495 and r = 0.642 for 100 and 120 kV protocol, respectively). Similarly, NoiseTB was much more closely related to NoiseCCTA ( r = 0.740 and r = 0.630 for 100 and 120 kV protocol, respectively) when compared with BW, BMI, and BSA. Conclusion It is feasible to individually adapt tube current and contrast injection protocol of CCTA based on the information of test bolus.
Surrogacy assessment using principal stratification and a Gaussian copula model
Authors: Conlon ASC , Taylor JMG , Elliott MR 
Published: June 2014

In clinical trials, a surrogate outcome ( S) can be measured before the outcome of interest ( T) and may provide early information regarding the treatment ( Z) effect on T. Many methods of surrogacy validation rely on models for the conditional distribution of T given Z and S. However, S is a post-randomization variable, and unobserved, simultaneous predictors of S and T may exist, resulting in a non-causal interpretation. Frangakis and Rubin developed the concept of principal surrogacy, stratifying on the joint distribution of the surrogate marker under treatment and control to assess the association between the causal effects of treatment on the marker and the causal effects of treatment on the clinical outcome. Working within the principal surrogacy framework, we address the scenario of an ordinal categorical variable as a surrogate for a censored failure time true endpoint. A Gaussian copula model is used to model the joint distribution of the potential outcomes of T, given the potential outcomes of S. Because the proposed model cannot be fully identified from the data, we use a Bayesian estimation approach with prior distributions consistent with reasonable assumptions in the surrogacy assessment setting. The method is applied to data from a colorectal cancer clinical trial, previously analyzed by Burzykowski et al.