bluuebunny/crossref_metadata_2025_split huggingface dataset:
Top‐cited articles in digestive system disease from 1950 to 2013
Authors: Tang Xiaowei , Gong Wei , Yuan Fangfang , Li Ran , Han Xiaomei , Huang Silin , Zhi Fachao , Jiang Bo 
Published: July 2015

AbstractBackground and AimExamination of top‐cited articles is a tool that can help to identify and monitor outstanding scientific researches and landmark papers. We aimed to identify the 100 most cited published papers in peer‐reviewed biomedical journals in the field of digestive diseases and to examine their characteristics.MethodsThe Web of Science (including Science Citation Index) was searched for the most cited papers related to digestive diseases, published from 1955 to the present. The top 100 most cited articles were identified. The number of citations, countries, and institutions of origin, year of publication, study design, topic, and levels of evidence of the articles were noted and analyzed.ResultsThe most top‐cited articles had a mean of 1375 citations. These articles were published between 1978 and 2009 in 29 high‐impact journals, with the New England Journal of Medicine (n = 22) topping the list. Of the 100 articles, 34 were clinical studies, 15 were review articles, and 34 were concerned basic science. These articles came from 18 countries, with the USA contributing most of the top‐cited articles (n = 53). Eighty‐seven institutions produced these 100 top‐cited articles, led by the University of Barcelona (n = 4). Seven persons authored two or more of these top‐cited articles. The mostly represented specialty was gastrointestinal oncology (n = 49).ConclusionsOur study can give a historical perspective on the scientific progress of digestive diseases, as well as allow for recognition of most important advances in this area and provide useful information to guide future researches.
Home‐made and commercial complementary meals in German infants: results of the DONALD study
Authors: Hilbig A. , Foterek K. , Kersting M. , Alexy U. 
Published: July 2015

AbstractBackgroundInfant complementary food can be home‐made or bought as ready‐to‐eat commercial products. The nutrient composition of commercial products is regularised in a European Commission guideline, whereas the preparation of home‐made complementary meals is the responsibility of caregivers. In the present study, the composition of commercial and home‐made complementary meals as eaten by healthy German infants was compared.MethodsOf 8226 complementary meals (74% commercial and 26% home‐made) recorded in 1083, 3‐day weighed dietary records from 396 participants (6–12 months old) of the German DONALD (DOrtmund Nutritional and Anthropometric Longitudinally Designed) study were analysed.ResultsMedian energy density (kcal 100 g–1) was highest in commercial and home‐made cereal–milk meals (89 kcal 100 g–1). In home‐made savoury and cereal–fruit meals, the energy density was significantly higher compared to their commercial counterparts. Median protein contents were highest in savoury and cereal–milk meals (>2.5 g 100 g–1) and dairy–fruit meals (2–4 g 100 g–1). Added sugars were found in less than a quarter of meals. Highest median sodium contents were found not only in commercial savoury meals (median 38 mg 100 g–1) and vegetable meals (32 mg 100 g–1), but also in home‐made cereal–milk meals (36 mg 100 g–1). Both median fat and iron contents were higher in home‐made meals compared to commercial savoury and cereal–fruit meals.ConclusionsWith the exception of the higher sodium content in commercial savoury meals for older infants, the lower fat content in commercial savoury and cereal–fruit meals, and the added sugar content in some commercial dairy–fruit meals, a comparison of commercial and home‐made complementary meals did not reveal any serious inadequacy.
Comparison of energy estimates in chronic kidney disease using doubly‐labelled water
Authors: Sridharan S. , Wong J. , Vilar E. , Farrington K. 
Published: July 2015

AbstractBackgroundTotal energy expenditure (TEE) is estimated in clinical practice as a combined measure of resting energy expenditure and physical activity level. Commonly available questionnaires to estimate physical activity level have not been validated in patients with kidney disease using the doubly‐labelled water method.MethodsThis prospective, cross‐sectional study was conducted on 40 patients with chronic kidney disease stages 1–5 with the objective of validating two physical activity questionnaires: the Recent Physical Activity Questionnaire (RPAQ) and the Stanford 7‐day recall questionnaire. TEE was measured using doubly‐labelled water technique. TEE was also estimated using predicted resting energy expenditure and estimated physical activity measures from the questionnaires.ResultsMeasured TEE correlated better with TEE estimated from RPAQ compared to that from the Stanford questionnaire. In Bland–Altman analysis, TEE estimated from RPAQ had the least bias and narrower limits of agreement compared to the measured TEE. A metabolic equivalent of task value of 1.3 for the unaccounted time in RPAQ provided the best approximation of estimated TEE to the measured TEE.ConclusionsRPAQ is an acceptable questionnaire tool for assessing physical activity level in patients with chronic kidney disease.
UHT metamorphism on Seram, eastern Indonesia: reaction microstructures and P–T evolution of spinel‐bearing garnet–sillimanite granulites from the Kobipoto Complex
Authors: Pownall J. M. 
Published: July 2015

AbstractThe island of Seram, part of the northern limb of the Banda Arc in eastern Indonesia, exposes an extensive Mio‐Pliocene granulite facies migmatite complex (the Kobipoto Complex) comprising voluminous leucosome‐rich diatexites and scarcer Al–Fe‐rich residual granulites. The migmatites are intimately associated with ultramafic rocks of predominantly lherzolitic composition that were exhumed by substantial lithospheric extension beneath low‐angle detachment faults; heat supplied by the lherzolites was evidently a major driver for the granulite facies metamorphism and accompanying anatexis. Residual garnet–sillimanite granulites sampled from the Kobipoto Mountains, central Seram, contain scarce garnet‐hosted inclusions of hercynite spinel (~1.5 wt% ZnO) + quartz (± ilmenite) in direct grain‐boundary contact – an assemblage potentially indicative of metamorphism under ultrahigh‐temperature (UHT) conditions. thermocalc ‘Average P–T’ reactions and melanosome‐specific thermocalc , T–MO, and P–T pseudosections in the Na2O–CaO–K2O–FeO–MgO–Al2O3–SiO2–H2O–TiO2–Fe2O3 (NCKFMASHTO) chemical system, supported by Ti‐in‐garnet thermobarometry, are permissive of the rock having experienced a clockwise P–T path peaking at 925 °C and 9 kbar – thus narrowly reaching UHT conditions – before undergoing near‐isothermal decompression to ~750 °C and ~4 kbar. Spinel + quartz assemblages are interpreted to have formed at or just after the metamorphic peak from localized reactions between sillimanite, ilmenite and surrounding garnet. Further decompression of the rock resulted in the formation of complex reaction microstructures comprising cordierite ± plagioclase coronae around garnet, and symplectic intergrowths of cordierite + spinel + ilmenite around sillimanite. Small grains of sapphirine + corundum developed subsequently within spinel by localized quartz‐absent reactions. The post‐peak evolution of the granulites may be related to previously published U–Pb zircon and 40Ar/39Ar ages of c. 16 Ma, further substantiating the claim for the Kobipoto Complex granulites having recorded Earth's youngest‐identified episode of UHT metamorphism, albeit at slightly lower temperature and higher pressure than previously inferred. The Kobipoto Complex granulites demonstrate how UHT conditions may be achieved in the ‘modern’ Earth by extreme lithospheric extension, which, in this instance, was driven by slab rollback of the Banda Arc.
Prospects for regenerative medicine approaches in women's health
Authors: Schenke‐Layland Katja , Brucker Sara Y. 
Published: July 2015

AbstractNovel regenerative strategies, stem cell‐based therapies or the development of advanced human cell‐based in vitro‐manufactured preclinical test systems offer great potential to generate advances in clinical practice in the field of women's health. This review aims to provide a brief overview of the current advances in the field.
Efficacy of diode laser (810 and 940 nm) for facial skin tightening
Authors: Voravutinon Nataya , Seawthaweesin Kanikar , Bureethan Apron , Srivipatana Anchisa , Vejanurug Patnapa 
Published: July 2015

SummaryBackgroundLaser treatment has been introduced for facial skin tightening. However, no prior study has used a diode laser to treat facial skin laxity.AimsTo evaluate the efficacy and safety of a 810‐ and 940‐nm diode laser (MeDioStarNeXT) for treating facial skin laxity.MethodsThirty patients, with facial skin laxity grading scale II‐IV, were enrolled in this study. Each patient underwent four sessions with a 810‐ and 940‐nm diode laser (MeDioStarNeXT) treatment over 3‐week intervals. Improvement in the laxity of facial skin was evaluated using a Cutometer MPA 580, spectrophotometer, and a grading scale.ResultsSignificant improvement was observed with the Cutometer F3 and R7 parameters at 1 and 3 months after complete treatment, respectively. Physician assessment showed significant improvement in the laxity scale at 1 and 6 months after treatment. Approximately 10% of the patients reported mild pain or minor adverse events. Ninety‐eight percent of the patients were satisfied with the treatments.ConclusionTreatment with a diode laser (810 and 940 nm) is safe and may be effective for facial skin tightening. Maintenance treatment is necessary to sustain the effect of treatment.
Changes in pelvic shape among Japanese pregnant women over the last 5 decades
Authors: Narumoto Keiichiro , Sugimura Motoi , Saga Kozue , Matsunaga Youichi 
Published: July 2015

AbstractAimPelvic shape affects the progression of labor. The gynecoid‐type pelvis has been the most common in women, but a previous study reported that the anthropoid type has increased in Japan. The purpose of this study was to examine: (i) the current prevalence of different pelvic shapes in Japanese pregnant women; and (ii) the changes in the prevalence of the pelvic shapes over the past 50 years.Material and MethodsWe conducted a cross‐sectional study using descriptive analysis for the prevalence of the pelvic shape and a historical comparison to assess the changes in the proportions of pelvic shapes with Japanese data from the 1960s to the 1980s. We reviewed a total of 517 delivery records from May 2010 to August 2012 at a rural Japanese hospital where prenatal X‐ray pelvimetry had been routinely performed as local practice. We analyzed the readings of the digital imaging data in pregnant women who underwent X‐ray pelvimetry.ResultsWe identified the X‐ray data in 326 Japanese pregnant women. The prevalence of the anthropoid, gynecoid and flat types was 151 (46.3%), 142 (43.6%), and 33 (10.1%), respectively. There were no differences in the maternal characteristics according to the pelvic shapes. The prevalence of the anthropoid‐type pelvis has increased by approximately 40% and that of the gynecoid type has decreased by 20% since the 1960s.ConclusionThe prevalence of the anthropoid‐type pelvis have significantly increased in Japan. Identifying a determinant of this phenomenon requires further research.
A Mobile Stroke Treatment Unit for Field Triage of Patients for Intraarterial Revascularization Therapy
Authors: Cerejo Russell , John Seby , Buletko Andrew B. , Taqui Ather , Itrat Ahmed , Organek Natalie , Cho Sung‐Min , Sheikhi Lila , Uchino Ken , Briggs Farren , Reimer Andrew P. , Winners Stacey , Toth Gabor , Rasmussen Peter , Hussain Muhammad S. 
Published: July 2015

ABSTRACTINTRODUCTIONFavorable outcomes in intraarterial therapy (IAT) for acute ischemic stroke (AIS) are related to early vessel recanalization. The mobile stroke treatment unit (MSTU) is an on‐site, prehospital, treatment team, laboratory, and CT scanner that reduces time to treatment for intravenous thrombolysis and may also shorten time to IAT.METHODSUsing our MSTU database, we identified patients that underwent IAT for AIS. We compared the key time metrics to historical controls, which included patients that underwent IAT at our institution six months prior to implementation of the MSTU. We further divided the controls into two groups: (1) transferred to our institution for IAT and (2) directly presented to our emergency room and underwent IAT.RESULTSAfter 164 days of service, the MSTU transported 155 patients of which 5 underwent IAT. We identified 5 historical controls that were transferred to our center for IAT. Substantial reduction in times including median door to initial CT (12 minute vs. 32 minute), CT to IAT (82 minute vs. 165 minute), and door to MSTU/primary stroke center departure (37 minute vs. 106 minute) were noted among the two groups. Compared to the 6 patients who presented to our institution directly, the MSTU process times were also shorter.CONCLUSIONOur initial experience shows that MSTU may help in early triage and shorten the time to IAT for AIS.
Distribution and population structure of deep‐dwelling red coral in the Northwest Mediterranean
Authors: Angiolillo Michela , Gori Andrea , Canese Simonepietro , Bo Marzia , Priori Cristina , Bavestrello Giorgio , Salvati Eva , Erra Fabrizio , Greenacre Michael , Santangelo Giovanni 
Published: July 2015

AbstractCommercially harvested since ancient times, the highly valuable red coral Corallium rubrum (Linnaeus, 1758) is an octocoral endemic to the Mediterranean Sea and adjacent Eastern Atlantic Ocean, where it occurs on rocky bottoms over a wide bathymetric range. Current knowledge is restricted to its shallow populations (15–50 m depth), with comparably little attention given to the deeper populations (50–200 m) that are nowadays the main target of exploitation. In this study, red coral distribution and population structure were assessed in three historically exploited areas (Amalfi, Ischia Island and Elba Island) in the Tyrrhenian Sea (Western Mediterranean Sea) between 50 and 130 m depth by means of ROV during a cruise carried out in the summer of 2010. Red coral populations showed a maximum patch frequency of 0.20 ± 0.04 SD patches·m−1 and a density ranging between 28 and 204 colonies·m−2, with a fairly continuous bathymetric distribution. The highest red coral densities in the investigated areas were found on cliffs and boulders mainly exposed to the east, at the greatest depth, and characterized by medium percentage sediment cover. The study populations contained a high percentage (46% on average) of harvestable colonies (>7 mm basal diameter). Moreover, some colonies with fifth‐order branches were also observed, highlighting the probable older age of some components of these populations. The Ischia population showed the highest colony occupancy, density and size, suggesting a better conservation status than the populations at the other study locations. These results indicate that deep dwelling red coral populations in non‐stressed or less‐harvested areas may diverge from the inverse size‐density relationship previously observed in red coral populations with increasing depth.
Crustacean decapod assemblages associated with fragmented Posidonia oceanica meadows in the Alboran Sea (Western Mediterranean Sea): composition, temporal dynamics and influence of meadow structure
Authors: Mateo‐Ramírez Ángel , Urra Javier , Marina Pablo , Rueda José L. , García Raso José Enrique 
Published: July 2015

AbstractThe decapod assemblage associated with a Posidonia oceanica meadow located near its western limit of biogeographic distribution was studied over an annual cycle. Fauna samples were taken seasonally over a year (five replicates per season) in two sites located 7 km apart, using a non‐destructive sampling method (airlift sampler) for the seagrass. The dominant species of the assemblage, Pisidia longimana, Pilumnus hirtellus and Athanas nitescens, were associated with the protective rhizome stratum, which is mainly used as a nursery. The correlations between decapod assemblage structure and some phenological parameters of the seagrass shoots and wave height were negative or null, which reflects that species associated with the rhizome had a higher importance than those associated with the leaf stratum. The abundance and composition of the decapod assemblage as well as the ecological indexes displayed a seasonality trend with maximum values in summer‐autumn and minimum in winter‐spring, which were related to the seawater temperature and the recruitment periods of the dominant species. The spatial differences found in the structure and dynamics of the assemblages may be due to variations in the recruitment of the dominant species, probably as a result of the influence of local factors (e.g. temperature, currents) and the high dispersal ability of decapods, together with the patchy configuration and the surrounding habitats. The studied meadows are fragmented and are integrated within a mosaic of habitats (Cymodocea nodosa patches, algal meadows, rocky and sandy bottoms), which promotes the movement of individuals and species among them, maintaining a high species richness and evenness.
Puppets as a strategy for communication with Brazilian children with cancer
Authors: Sposito Amanda Mota Pacciulio , de Montigny Francine , Sparapani Valéria de Cássia , Lima Regina Aparecida Garcia de , Silva‐Rodrigues Fernanda Machado , Pfeifer Luzia Iara , Nascimento Lucila Castanheira 
Published: July 2015

AbstractChildren are considered competent social actors. Although they are able to express their opinions, they may have some difficulties in answering direct verbal questions, requiring researchers and health professionals to enter their world by using auxiliary resources for communication. This study presents the experience of using finger puppets as a playful strategy for improving interaction and communication with hospitalized children with cancer, aged seven to 12. It describes the strategy of making and using puppets as an auxiliary tool to communicate with children with cancer and presents the results and limitations of using puppets in clinical practice. The use of the puppets, creatively and in accordance with the children's motor, cognitive, and emotional development, showed benefits, such as allowing the children to freely express themselves; respecting their autonomy; and minimizing the hierarchical adult‐child relationship. The use of puppets is an appropriate strategy to communicate with hospitalized children. This tool can also enrich clinical practice, as it encourages children with cancer to report their experience of being ill and also helps the health team during evaluation and intervention.
Idiopathic pulmonary fibrosis is associated with increased impedance measures of reflux compared to non‐fibrotic disease among pre‐lung transplant patients
Authors: Gavini S. , Finn R. T. , Lo W.‐K. , Goldberg H. J. , Burakoff R. , Feldman N. , Chan W. W. 
Published: July 2015

AbstractBackgroundGastroesophageal reflux (GER) has been associated with idiopathic pulmonary fibrosis (IPF), although the mechanism remains unclear. Gastroesophageal reflux/microaspiration may lead to lung fibrosis, while increased pulmonary workload may also worsen GER. Comparing the GER profile of IPF patients to chronic obstructive pulmonary disease (COPD) patients with similar lung function may help delineate the role of GER in IPF pathogenesis.MethodsThis was a retrospective cohort study of IPF and COPD patients undergoing pre‐lung transplant multichannel intraluminal impedance and pH study (MII‐pH) off acid suppression at a tertiary center in 2008–2014. Patients with prior fundoplication were excluded. Baseline demographics, pulmonary function test, and MII‐pH results were recorded. Univariate analyses were performed using Fisher's exact (binary variables) and Student's t (continuous variables) tests. Logistic regression was performed to adjust for potential confounders.Key ResultsA total of 90 subjects (54 IPF, 36 COPD) met inclusion criteria. Compared to COPD, IPF patients had increased total reflux episodes (65.9 vs 46.1, p = 0.02), proximal reflux episodes (30.3 vs 20.3, p = 0.04), and prevalence of abnormal total reflux episodes (38.9% vs 16.7%, p = 0.02). On multivariate analyses, abnormal total reflux episodes (OR: 4.9, p = 0.05) and bolus reflux exposure time (OR: 4, p = 0.04) remained significantly associated with IPF.Conclusions & InferencesAbnormal reflux was significantly more prevalent among IPF patients after controlling for lung disease severity. Gastroesophageal reflux/microaspiration likely plays a role in fibrosis in IPF. A significant portion of IPF patients had increased non‐acid reflux. Therapies aiming to prevent reflux of gastric contents may be more beneficial than antisecretory medications alone in these patients.
Association of high dietary saturated fat intake and uncontrolled diabetes with constipation: evidence from the National Health and Nutrition Examination Survey
Authors: Taba Taba Vakili S. , Nezami B. G. , Shetty A. , Chetty V. K. , Srinivasan S. 
Published: July 2015

AbstractBackgroundConstipation is highly prevalent in the United States. The association of dietary fat intake with constipation has not been well studied. We recently reported that mice fed a high‐fat diet had higher incidence of constipation than regular diet fed mice. The aim of this study was to assess if increased intake of dietary saturated fat in humans is also associated with higher risk of constipation and reduced stool frequency.MethodsAnalyses were based on data from 6207 adults (≥20 years) from the 2005–2006 and 2007–2008 cycles of the National Health and Nutrition Examination Surveys who had completed the bowel health questionnaire. Constipation was defined as a stool frequency of less than three times per week. Multivariable logistic regression analysis was used to calculate adjusted prevalence odds ratio (OR) estimates. Statistical analyses were performed using R and RStudio softwares.Key ResultsThe prevalence of constipation in this sample was 3.1%. After multivariable adjustment high saturated fat remained associated with constipation. The OR for high saturated fat intake associated with constipation was much higher in diabetics above 65 years, especially in non‐Hispanic blacks, females, and those with poor glycemic control, compared to the control group.Conclusions & InferencesTo the best of our knowledge, this is the first report to investigate the association of high saturated fat diet, bowel frequency, and diabetes. This study demonstrates that a high dietary saturated fat intake is associated with significant increase in the prevalence of constipation, especially in the uncontrolled diabetic, non‐Hispanic black, female patients.