bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perencanaan Sistem Teknologi Informasi untuk Mendeteksi dan Mencegah Fraud pada Sistem Inventori
Authors: Hidayat Imam 
Published: July 2024

Dalam penelitian ini coba dikembangkan dan diterapkan suatu sistem informasi untuk mendeteksi dan mencegah terjadinya fraud pada suatu sistem inventori, yang dalam hal ini terdapat pada suatu industri pengepakan. Dalam pembentukan sistem informasi ini diterapkan langkah-langkah strategi untuk pendeteksian fraud yang terdiri atas pemahaman terhadap sistem atau unit, pengidentifikasian terhadap fraud yang mungkin terjadi, mengumpulkan gejala-gejala dariÂ fraudÂ dalam suatu daftar, pengumpulan data-data yang yang terkait dengan gejalaÂ fraudÂ tersebut, dan pembuatan suatu program komputer yang merupakan hasil akhir, yang dapat menganalisis secara otomatis untuk mendeteksi terjadinya fraud tersebut. Dari penerapan program yang dibuat (secara simulasi) kepada sistem yang ada pada industri yang diuji, maka didapat beberapa gejala fraud yang terdeteksi yang dapat dianggap sebagai fraud yang berupa: (a) Perencanaan pembelian atas material yang jarang digunakan, sehingga nantinya material tersebut akan menjadi deadstock dan dijual dengan harga yang rendah, (b) Penghapusan material yang bernilai dan masih berguna, akibat adanya kesalahan pencatatan material yang sudah rusak (deadstock), (c) kesalahan pengambilan stok material, dan tidak melakukan penyesuaian terhadap arsip dari material tersebut, dan (d) Pemberian insentif yang tidak seharusnya, karena adanya kesalahan perhitunganÂ waste. Sistem ini nantinya dapat digunakan secara periodik yang berfungsi untuk mendeteksi kesalahan-kesalahan yang merupakan gejala sebelum fraud yang dapat menimbulkan kerugian yang besar terjadi.
Analisis Eksperimental Profil Vortex Bebas Dengan Variasi Lubang Bawah Tabung Silinder
Authors: Suwasti Sri 
Published: July 2024

Penelitian ini bertujuan mengetahui profil permukaan dari vortex bebas dengan menjelaskan pengaruh diameter lubang bawah pada tabung silinder yaitu, 1,75 cm dan 2,75 cm. Metode pengambilan data dilakukan dua cara yaitu, pertama metode eksperimen dengan menvariasikan tinggi pengukuran permukaan vortex 11 cm, 14 cm,17 cm dan data yang akan diperoleh adalah jarak dari pusat tabung dan kedua metode secara visual berupa gambar dengan menggunakan kamera digital. Hasil penelitian menunjukkan bahwa vortex bebas membentuk hyperbolaÂ asymptoticÂ dengan diameter pusaran bertambah besar jika diameter lubang bawah tabung silinder juga bertambah.
Mutant NOTCH3ECD Triggers Defects in Mitochondrial Function and Mitophagy in CADASIL Cell Models
Authors: Wang Wan , Gong Zhenping , Wang Yadan , Zhao Ying , Lu Yaru , Sun Ruihua , Zhang Haohan , Shang Junkui , Zhang Jiewen 
Published: July 2024

Background: Cerebral autosomal-dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL) is an inherited small-vessel disease that affects the white matter of the brain. Recent studies have confirmed that the deposition of NOTCH3ECD is the main pathological basis of CADASIL; however, whether different mutations present the same pathological characteristics remains to be further studied. Some studies have found that mitochondrial dysfunction is related to CADASIL; however, the specific effects of NOTCH3ECD on mitochondrial remain to be determined. Objective: We aimed to explore the role of mitochondrial dysfunction in CADASIL. Methods: We established transgenic human embryonic kidney-293T cell models (involving alterations in cysteine and non-cysteine residues) via lentiviral transfection. Mitochondrial function and structure were assessed using flow cytometry and transmission electron microscopy, respectively. Mitophagy was assessed using western blotting and immunofluorescence. Results: We demonstrated that NOTCH3ECD deposition affects mitochondrial morphology and function, and that its protein levels are significantly correlated with mitochondrial quality and can directly bind to mitochondria. Moreover, NOTCH3ECD deposition promoted the induction of autophagy and mitophagy. However, these processes were impaired, leading to abnormal mitochondrial accumulation. Conclusions: This study revealed a common pathological feature of NOTCH3ECD deposition caused by different NOTCH3 mutations and provided new insights into the role of NOTCH3ECD in mitochondrial dysfunction and mitophagy.
Exposure to Glycolysis-Enhancing Drugs and Risk of Parkinson’s Disease: A Meta-Analysis
Authors: Ribeiro Giovana Barros e Silva , Rodrigues Farley Reis , Pasqualotto Eric , Dantas Julyana Medeiros , Di Luca Daniel G. 
Published: July 2024

Background: Impaired glucose and energy metabolism has been suggested as a pathogenic mechanism underlying Parkinson’s disease (PD). In recent cohorts, phosphoglycerate kinase 1 activators (PGK1a) have been associated with a lower incidence of PD when compared with other antiprostatic agents that do not activate PGK1. Objective: We aimed to perform a systematic review and meta-analysis comparing the incidence of PD in patients taking PGK1a versus tamsulosin. Methods: We searched PubMed, Embase, and Cochrane Library for studies comparing PGK1a vs. tamsulosin in adults and elderly. The primary outcome was the incidence of PD. We computed hazard ratios (HR) for binary endpoints, with 95% confidence intervals (CIs). Statistical analysis was performed using Review Manager 5.4 and R (version 4.3.1). Results: A total of 678,433 participants from four cohort studies were included, of whom 287,080 (42.3%) received PGK1a. Mean age ranged from 62 to 74.7 years and nearly all patients were male. Patients taking PGK1a had a lower incidence of PD (PGK1a 1.04% vs. tamsulosin 1.31%; HR 0.80; 95% CI 0.71–0.90; p < 0.01). This result remained consistent in a sensitivity analysis excluding patients of age 60 years old or younger (PGK1a 1.21% vs. tamsulosin 1.42%; HR 0.82; 95% CI 0.71–0.95; p < 0.01). Conclusions: Glycolysis-enhancing drugs are associated with a lower incidence of PD when compared with tamsulosin in adults and elderly individuals with prostatic disease in use of alpha-blockers. Our findings support the notion of glycolysis as a potential neuroprotective mechanism in PD. Future investigations with randomized controlled trials are needed.
Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2024 Update
Authors: McFarthing Kevin , Buff Sue , Rafaloff Gary , Pitzer Kenneth , Fiske Brian , Navangul Anaya , Beissert Katelyn , Pilcicka Aleksandra , Fuest Rosie , Wyse Richard K. , Stott Simon R.W. 
Published: July 2024

Background: For the past five years, our annual reports have been tracking the clinical development of new drug-based therapies for the neurodegenerative condition of Parkinson’s disease (PD). These reviews have followed the progress both of “symptomatic treatments” (ST – improves/reduces symptoms of the condition) and “disease-modifying treatments” (DMT – attempts to delay/slow progression by addressing the underlying biology of PD). Efforts have also been made to further categorize these experimental treatments based on their mechanisms of action and class of drug. Methods: A dataset of clinical trials for drug therapies in PD using trial data downloaded from the ClinicalTrials.gov online registry was generated. A breakdown analysis of all the studies that were active as of January 31st, 2024, was conducted. This analysis involved categorizing the trials based on both the mechanism of action (MOA) and the drug target. Results: There were 136 active Phase 1–3 trials evaluating drug therapies for PD registered on ClinicalTrials.gov, as of January 31, 2024. Of these trials, 76 (56%) were classified as ST trials and 60 (44%) were designated DMT. More than half (58%) of the trials were in Phase 2 testing stage, followed by Phase 1 (30%) and Phase 3 (12%). 35 of the trials were registered since our last report, with the remaining 101 trials appearing in at least one earlier report. Conclusions: The drug development pipeline for PD remains in a robust state with a wide variety of approaches being developed and evaluated in Phase 1 and 2. Yet again, however, only a limited number of DMTs are transitioning to Phase 3.
Healthcare system variability and inpatient maternal mortality in the United States
Authors: Mohamed M.A. , Venkatesh K. , Abdelatif D. , Nandakumar V. , Hoffman H. 
Published: July 2024

OBJECTIVE: To examine the association of inpatient maternal mortality with variability in healthcare services delivery such as hospital size, urban/rural designation, teaching/non-teaching status, regional location, and insurance coverage. METHODS: This is a pooled, cross-sectional analysis of the National Inpatient Sample (2012–2014). Information on maternal demographics, clinical conditions, and birth outcomes were identified using respective ICD9-CM codes. Bivariate and multivariate analysis using logistic regression models were used to describe maternal characteristics and to calculate the risk of mortality with each independent variable RESULTS: The weighted sample included 12,409,939 hospital records (82.6% are 18–34-year-old and 49.5% are Caucasians). Maternal death during hospitalization occurred in 1310 cases (12/100,000 live birth). Women with cardiovascular disorders, hemorrhage or sepsis were 33.6, 4.7, and 5.4 times more likely to suffer inpatient maternal mortality. Compared to small-sized hospitals, delivery at medium or large size hospitals is associated with higher mortality, adjusted odds ratios (aOR) 1.8 (1.4–2.3), and 2.2 (1.8–2.8), respectively. Adjusted OR for inpatient maternal mortality in urban non-teaching or urban teaching compared to rural hospitals were 2.2 (1.7–3.0) and 2.9 (2.2–3.9), respectively. Women in the South have higher maternal mortality compared to Northeast, aOR 1.7 (1.5–2.1). Women coved with public insurance experience higher inpatient maternal mortality compared to those with private insurance, aOR: 2.6 (2.1–3.2) and 1.9 (1.6–2.1), respectively. CONCLUSION: Factors related to variability in healthcare delivery may play a role in inpatient maternal mortality. Some could be explained by the case mix and the clinical conditions affecting birthing outcomes. A qualitative analysis is needed to explore how these factors relate to increased maternal mortality in certain hospital settings.
Pengaruh Pelayanan Informasi Obat (PIO) Metode Leaflet Kombinasi Pill Count Dalam Meningkatkan Kepatuhan Minum Obat Pada Pasien Tuberkulosis Di Puskesmas Pattingalloang Kota Makassar
Authors: Rusdiaman Rusdiaman , Rusli Rusli , Yuniati Yuniati 
Published: July 2024

Indonesia adalah negara dengan tendensi tuberkulosis paru tertinggi urutan kedua di dunia. Insidensi kejadian tuberkulosis setiap tahunnya mengalami kemajuan dari 331.703 kasus pada tahun 2015 menjadi 562.049 kejadian dengan presentasi yang lebih dari 69% di tahun 2019. Penelitian ini bertujuan untuk menganalisis pengaruh penanganan pelayanan informasi obat menggunakan metode leaflet ditambah metode pill count pada pengurutan menggunakan obat pada penderita Tuberkulosis di Puskesmas Pattingalloang Kodya Makassar. Model penelitian ini adalah eksperimental yang dilakukan secara prospektif terhadap pasien tuberkulosis di Puskesmas Pattingalloang dengan pelayanan informasi obat metode leaflet kombinasi pill count. Model atau bentuk pengambilan contoh dengan sistem purposive sampling menggunakan kriteria yang ditetapkan, 25 responden kelompok kontrol dan 25 responden kelompok treatment. Penelitian menerapkan uji chi square memperlihatkan bahwa tidak terdapat perbedaan ketaatan atau penurutan yang bermakna pada pasien tuberkulosis di Puskesmas Pattingalloang Kota Makassar melalui pemberian leaflet.
Kata Kunci : Kepatuhan, Tuberkulosis, Leaflet, Pill Count
Hasil Pemeriksaan Genexpert Terhadap Jumlah Dan Jenis Sel Leukosit Pada Pasien Suspek Tuberkulosis
Authors: Hartono Rudy , TANDJUNGBULU YAUMIL FACHNI , Virgiawan Alfin Resya , Rafika Rafika , Manasa Pratiwi Safitri 
Published: July 2024

Tuberkulosis merupakan penyakit menular yang disebabkan oleh infeksi bakteri Mycobacterium tuberculosis, dalam menunjang penegakan diagnosa tuberkulosis sejak tahun 2010 World Health Organization merekomendasikan penggunaan GeneXpert MTB/RIF untuk mendeteksi penderita tuberkulosis dengan cepat, tepat, dan akurat sehingga penatalaksanaan penderita dapat dilakukan sedini mungkin. Mycobacterium tuberculosis saat menginvasi tubuh dapat menstimulasi mekanisme kerja sistem imun yang tentunya dapat mempengaruhi total jumlah dan jenis dari sel leukosit, sehingga diperlukan pemeriksaan penunjang antara lain pemeriksaan total jumlah dan hitung jenis sel leukosit untuk melihat tingkat keparahan infeksi yang dialami penderita. Penelitian ini bertujuan untuk melihat korelasi hasil pemeriksaan GeneXpert terhadap total jumlah dan hitung jenis sel leukosit pada pasien suspek tuberkulosis, menggunakan jenis penelitian korelasional dengan pendekatan cross sectional, jumlah sampel sebanyak 36 sampel yang memenuhi kriteria inklusi penelitian. Pengumpulan dan pemeriksaan sampel dilakukan di Laboratorium Patologi Klinik Rumah Sakit Umum Daerah Bumi Panua Pohuwato Gorontalo selama 8-14 Maret 2023. Hasil penelitian diperoleh bahwa terdapat hubungan yang signifikan antara hasil pemeriksaan GeneXpert terhadap total jumlah leukosit p=0.000 (<0.05), hitung jenis neutrofil p=0.004 (<0.05), limfosit p=0.032 (<0.05), dan monosit p=0.010 (<0.05) pada pasien suspek tuberkulosis, dan tidak terdapat hubungan yang signifikan antara hasil pemeriksaan GeneXpert terhadap hitung jenis eosinofil p=0.899 (>0.05) dan basofil p=0.391 (>0.05) pada pasien suspek tuberkulosis, sehingga dapat disimpulkan bahwa pemeriksaan total jumlah leukosit dan hitung jenis neutrofil, limfosit, serta monosit yang dikombinasikan dengan pemeriksaan GeneXpert dapat menjadi biomarker laboratorium potensial dalam penegakan diagnosa dan penatalaksanaan pada penderita tuberkulosis.

Kata Kunci: GeneXpert, Sel Leukosit, Tuberkulosis
Hubungan Pengetahuan Ibu Hamil dengan Gingivitis Selama Kehamilan di Puskesmas Bahodopi Kabupaten Morowali
Authors: Aulyah Dwi Rezky , Pariati  , Usman Faradillah , Jauharuddin Arfiah , Sundu Suciyati 
Published: July 2024

Ibu hamil merupakan salah satu kelompok rentan akan berbagai macam penyakit khususnya penyakit gigi dan mulut. Kehamilan merupakan suatu proses perubahan dalam rangka melanjutkan keturunan yang terjadi secara alami, menghasilkan janin yang tumbuh dalam rahim ibu, tingkat pertumbuhan dan besarnya janin sesuai usia kehamilan. Tujuan penelitian ini adalah untuk Mengetahui hubungan antara tingkat pengetahuan ibu hamil terhadap gingivia di puskesmas bahodopo kabupaten morowali. Jenis penelitian ini adalah penelitian survei analitik. Desain penelitian yang digunakan adalah kuantitatif dengan pendekatan cross sectional. Teknik pengambilan sampel pada penelitian ini adalah non probability sampling dengan cara accidental sampling sejumlah 34 orang. Hasil penelitian ini menunjukkan Pengetahuan ibu hamil yang berpengetahuan baik sebanyak 15 responden, berpegetahuan cukup sebanyak 14 responden dan berpengetahuan kurang sebanyak 5 responden. Ibu hamil dengan pengetahuan baik rentang mengalami radang gusi dengan kategori berat sebanyak 7 orang (46,7%) dan ibu dengan pengetahuan cukup memiliki radang gusi dalam kategori sedang sebanyak 7 orang (50%) dan ibu hamil yang memilliki pengetahuan kurang memiliki radang gusi dalam kategori sedang sebanyak 4 orang.Berdasarkan hasil uji hubungan chi-squared di ketahui bahwa nilai p -value 0,244 > dari 0,05 yang artinya bahwa pengetahuan ibu hamil pada masa kehamilan tidak memiliki hubungan yang erat antara pengetahuan dangan gingivitis.
Reminder Minum Tablet Tambah Darah (TTD) sebagai Antisipasi Peningkatan Kadar Hemoglobin Ibu Hamil Beresiko Stunting di Desa Adipuro
Authors: Pramono Didi , Indarti Eka , Oktavia Hasna Tri , Af'idah Nabila Zakiyyatul 
Published: July 2024

Salah satu upaya untuk pencegahan resiko stunting pada ibu hamil, kelompok UNNES GIAT 5 Desa Adipuro melakukan pengabdian berupa “Gerakan Rutin Minum TTD”. Sasaran dari gerakan ini adalah ibu hamil dengan anemia yang beresiko stuting pada Desa Adipuro. Pengabdian ini bertujuan untuk mengetahui pengaruh pemberian TTD dengan menerapkan Reminder Sistem melalui pesan broadcast dan kotak centag pada ibu hamil anemia terhadap peningkatan Hb di Desa Adipuro. Pengabdian ini menggunakan metode quasi eksperimental one group pretset postest dengan populasi ibu hamil di Desa Adipuro dan total sampling sebanyak 4 ibu hamil anemia beresiko sunting. Analisa data menggunakan analisis dengan pairet T test. Kadar Hb pada responden sebelum diberikan tablet Fe didapatkan rata-rata sebesar 8,7 g/dl, dan sesudah diberikan perlakuan selama 2 minggu didapatkan rataan hemoglobin sebesar 10,15 g/dl dengan p value sebesar 0,27. Hasilnya terdapat peningkatan kadar hemoglobin pada ibu hamil anemia beresiko stunting di Desa Adipuro 2023.
The Body Unmatched
Authors: Anderson Mikey 
Published: July 2024

Engulfed by gender dysphoria? A feeling as if your body is other, wrong, mismatched, misconstructed, or visibly queer in the therapeutic milieu. Why does it feel overwhelming as a practicing queer art therapist to explore my own experience with gender even alongside gender-diverse clients? I find myself combing through those ruminating thoughts as depicted in my comic with the overwhelming amounts of slime taking over the composition–can the client tell? Can they see my dysphoria? The eating disorder that led to my experiences of this oozing effect of dysphoria? The restricting of calories to punish my body? How can I, the art therapist, be an expert on eating? “Eating healthy?” Body image? Exercise? Gender? Dysphoria? Euphoria? Will they still trust me if they knew? What if I can’t even accept my own body? Sharing similar experiences of living in a body that feels queer in the most literal sense – strange, odd, different – a struggle that might be a point of connection even across differences…I wonder: Should I disclose? Is that crossing a line? How can I navigate this ethical dilemma when the literature and professional discourse neglect to attend to these queer concerns?
In an attempt to depict this idea of gender dysphoria impacted by an eating disorder, I leaned into my artist identity as an art therapist by creating a comic using an oozing slime texture to engulf the disengaged figure in the comic. This slime, sticky and elastic in texture, represents the overwhelming thoughts of living in a body that sometimes feels and looks otherworldly to cis-normative bodies and ideals that conform to society. Slime captures the experience of a body feeling malleable, genderless, organic, and otherworldly. Slime often gets tied to language such as gross, weird, and strange, which historically gets tied to queer bodies. However, as a queer artist growing up in the nineties, the images of slime feel nostalgic, safe, and a recurring theme in my other artworks.
The comic intends to bring up, for the viewer, thoughts about how an artist and therapist experience their body both physically and mentally in the therapeutic space. In what ways do they perform gender? Succumb to gender norms? It invites queer therapists to give themselves grace in the therapy space and continue expressing their gender authentically while asking why it also often feels like an endless pursuit.
Body Unmatched shows the painful turmoil one can go through to come to a space of accepting one's body and the disordered eating through the repetitive line work in the comic. It brings to light the constant battle or discussion in one's mind about the gendered expectations of others, and self-reflection.
BATASAN USIA KANDUNGAN ANAK SAH TERHADAP WALI NASAB
Authors: Hari mulyanto Ana maulida sabila 
Published: July 2024

Penelitian ini ini bertujuan untuk mengetahui tinjauan hukum Islam dalam penentuan batasan usia kandungan terhadap status anak dan wali nasab. Penulis mengumpulkan data tentang cara tokoh agama dalam menyelesaikan permasalahan status nasab anak dari wali nasab di desa Pundong. Penelitian ini adalah penelitian kualitatif lapangan dengan pendekatan yuridis sosiologis. Teknik pengumpulan data yaitu wawancara, observasi, dan dokumentasi. Penulis menggunakan teknik analisis data secara deskriptif. Penelitian ini menyimpulkan bahwa penyelesaian status nasab anak dari wali nasab masyarakat desa Pundong Kecamatan Diwek Kabupaten Jombang mengikuti aturan yang dibuat oleh negara, yaitu mengikutkan nasab anak kepada ayah pernikahan ibuya yang sah.Penyelesaian masalah ini sudah sesuai dengan aturan negara. Logika hukum yang dibangun adalah peraturan negara tidak menyebutkan batasan-batasan usia kehamilan untuk penentuan status anak sah.
Rapid detection of human cytomegalovirus by multienzyme isothermal rapid amplification and lateral flow dipsticks
Authors: Liu Ming-hui , Guo Xiaochong , Sun Mao-ling , Li Jia-lun , Liu Shu-han , Chen Yun-zhou , Wang Dong-yi , Wang Lan , Li Yu-zhang , Yao Jun , Li Yang , Pan Yu-qing 
Published: July 2024

IntroductionHuman cytomegalovirus (HCMV) is the most common viral infection seen in newborns. The major route of transmission for acquired human cytomegalovirus infection is breast milk from mothers who are HCMV seropositive to the infants. Thus, a rapid, economical, and simple method to perform HCMV test in breast milk is crucial and necessary for preventing acquired HCMV infection, especially in underdeveloped regions with limited laboratory resources.MethodsIn this study, an effective technique for the detection of HCMV was constructed by combining multienzyme isothermal rapid amplification (MIRA) and lateral flow chromatography strip (LFD). Primers for the conserved HCMV sequence UL83 were utilized for MIRA-LFD testing.ResultsOur results showed that the entire MIRA reaction could be completed in 12 minutes at 37°C, and LFD outcomes could be observed visibly after 10 minutes. The detection sensitivity of this method reached 50 copy/μl. Samples of breast milk were examined to compare MIRA-LFD and conventional qPCR. The accuracy of MIRA-LFD was 100%.DiscussionThe straightforward, rapid, economic features of the test can provide the significant advantages for the prevention of breast milk-acquired cytomegalovirus infection, particularly in resource-limited locations with high seroprevalence of cytomegalovirus.