bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENDIDIKAN AKHLAK DALAM ALQURAN MENURUT TAFSIR AL-MISHBAH DAN RELEVANSINYA DENGAN PENDIDIKAN ISLAM MASA MODERN (SURAH ALI IMRAN AYAT 159, SURAH AL-AN’AM AYAT 151, SURAH AL-ISRA AYAT 23-24)
Authors: Ilmillah Fadlilatul 
Published: August 2024

Nowadays, juvenile delinquency is very worrying. One of the factors is moran degeneration. This incident is contrary to the purpose of Islamic Education in schools, namely to increase faith and piety as well as fostering gloriuous morals. The purposes of this research are: (1) To describe the interpretation of al-Mishbah on moral education verses in Quran (2) To describe relevance moral education in Quran with modern Islamic education. This research used qualitative approach with library research type. As for the technique used in this research is documentation technique, namely data collection in the form of Quran verses related to the research object. These research results showed that: (1) The interpretation of al-Mishbah regarding the moral education contained in the Quran is birrul walidain education, be gentle with everyone, and easy to forgive (2) The relevance of moral education in Quran with the modern Islamic education is to teach birrul walidain education, and teacher becomes the role model to show gentleness, and forgiveness

Abstrak
Pada zaman sekarang, kenakalan remaja sangat memprihatinkan. Salah satu penyebabnya adalah kemerosotan moral. Peristiwa tersebut bertolak belakang dengan tujuan pendidikan Islam di sekolah yaitu untuk meningkatkan keimanan dan ketaqwaan serta pembinaan akhlak mulia dan budi pekerti luhur. Oleh karena itu, tujuan dari penelitian ini (1) Mendeskripsikan tafsir al-Mishbah tentang ayat-ayat pendidikan akhlak dalam Alquran (2) Mendeskripsikan relevansi pendidikan akhlak dalam Alquran dengan pendidikan Islam masa modern. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian library research (kepustakaan). Adapun teknik yang digunakan dalam penelitian ini adalah teknik dokumentasi, yaitu pengumpulan data berupa ayat-ayat Alquran yang berkaitan dengan objek penelitian. Hasil penelitian ini menunjukkan bahwa: (1) Tafsir al-Mishbah tentang pendidikan akhlak yang terkandung dalam Alquran adalah pendidikan birrul walidain, bersikap lemah lembut kepada semua orang, mudah memaafkan, dan bermusyawarah (2) Relevansi pendidikan akhlak dalam Alquran dengan pendidikan Islam masa kini adalah mengajarkan pendidikan birrul walidain, serta pendidik menjadi teladan untuk menunjukkan sikap lemah lembut, dan mudah memaafkan.
MENINGKATKAN KEMAMPUAN MENGHAFAL HURUF HIJAIYAH DENGAN MENGGUNAKAN METODE MULTIMEDIA/GADGET KELOMPOK B2 DI TK TANWIRUL HUDA PADANGSARI MAJENANG
Authors: Nur Neli Alfi , Yaqien Nurul , Rossidy Imron 
Published: August 2024

This research is based on the problem of (a) How is the application of multimedia/gadget methods in improving the ability to memorize Hijaiyah letters in Tanwirul Huda Kindergarten Padangsari Majenang? (b) What is the impact of using multimedia/gadget methods on children's motivation and interest in memorizing the Hijaiyah Letters at Tanwirul Huda Kindergarten Padangsari Majenang? Meanwhile, the aim of this research is (a) Improving the ability to memorize the Hijaiyah letters of children at Tanwirul Huda Kindergarten Padangsari Majenang through the use of multimedia/gadget methods. (b) Knowing the impact of using multimedia/gadget methods on children's motivation and interest in memorizing Hijaiyah Letters at Tanwirul Huda Kindergarten Padangsari Majenang. This research uses three rounds of action research. Each round consists of four stages, namely: Planning, Action, observation and reflection. The target of this research is grade 1 students for the 2023-2024 academic year. The data obtained is in the form of formative test results, observation sheets of teaching and learning activities. From the results of the analysis, it was found that student learning achievement increased from cycle I to cycle II, namely, pre-cycle (35%), cycle I (65%), cycle III (75%). The conclusion of this research is that the increase in the ability to memorize Hijaiyah letters using the Multimedia/Gadget Method for Group B2 at Tanwirul Huda Kindergarten Padangsari Majenang is very significant
Abstrak
Penelitian ini berdasarkan permasalahan (a) Bagaimana penerapan metode multimedia/gadget dalam meningkatkan kemampuan menghafal huruf Hijaiyah di TK Tanwirul Huda Padangsari Majenang? (b) Apa dampak penggunaan metode multimedia/gadget terhadap motivasi dan minat anak-anak dalam menghafal Huruf Hijaiyah di TK Tanwirul Huda Padangsari Majenang? Sedangkan tujuan dari penelitian ini adalah (a) Meningkatkan kemampuan menghafal Huruf Hijaiyah anak-anak di TK Tanwirul Huda Padangsari Majenang melalui penggunaan metode multimedia/gadget. (b) Mengetahui dampak penggunaan metode multimedia/gadget terhadap motivasi dan minat anak-anak dalam menghafal Huruf Hijaiyah di TK Tanwirul Huda Padangsari Majenang. Penelitian ini menggunakan penelitian tindakan (action research) sebanyak tiga putaran. Setiap putaran terdiri dari empat tahap yaitu : Perencanaan, Tindakan, observasi dan refleksi. Sasaran penelitian ini adalah siswa kelas 1 Tahun pelajaran 2023-2024. Data yang diperoleh berupa hasil tes formatif, lembar observasi kegiatan belajar mengajar. Dari hasil analis didapatkan bahwa prestasi belajar siswa mengalami peningkatan dari siklus I sampai siklus II yaitu, pra siklus (35%), siklus I (65%), siklus III (75%). Simpulan dari penelitian ini peningkatkan Kemampuan Menghafal Huruf Hijaiyah Dengan Menggunakan Metode Multimedia/Gadget Kelompok B2 Di TK Tanwirul Huda Padangsari Majenang sangat signifikan
Tindak Tutur Direktif dalam Sinema Salahuddin Al-batal Al-Ustūrah
Authors: Novriani Nadia , Afriani Susi Herti 
Published: August 2024

Penelitian ini bertujuan untuk menjelaskan bentuk dan fungsi “Tindak Tutur Direktif Dalam Sinema Salahuddin Al-Batal Al-Ustūrah Episode 23-25”.Penelitian ini menggunakan teori tindak tutur dari Searle. Metode dalam penelitian ini menggunakan metode simak dengan teknik pengumpulan datanya menggunakan teknik sadap, teknik simak bebas libat cakap dan teknik catat.Sedangkan metode analisisnya menggunakan metode padan, metode padan yang peneliti gunakan yaitu metode padan pragmatis yang mana alat penentunya adalah lawan atau mitra wicara. Teknik analisis datanya menggunakan teknik pilah unsur tertentu. Hasil akhir dari penelitian ini yaitu ditemukan tuturan direktif dalam sinema Salahuddin Al-Batal Al-Ustūrah Episode 23-25 sebanyak 104 tuturan. Adapun pembagiannya sebagai berikut: 18 tuturan berbentuk permintaan, 32 tuturan berbentuk pertanyaan, 34 tuturan berbentuk perintah, tujuh tuturan berbentuk pemberian izin, tujuh tuturan berbentuk nasihat dan enam tuturan berbentuk larangan. Dari keenam bentuk tindak tutur direktif dalam Sinema Salahuddin Al-Batal Al-Ustūrah Episode 23-25 bentuk perintah paling banyak ditemukan, sedangkan bentuk larangan paling sedikit ditemukan. Adapun fungsi tindak tutur direktif dalam sinema Salahuddin Al-Batal Al-Ustūrah Episode 23-25, ditemukan sebanyak 27 dari 38 macam fungsi tindak tutur direktif. Penelitian ini berkontribusi untuk menambah khazanah mufrodat bagi mahasiswa bahasa dan sastra arab yang mana dapat diambil dari dialog teks sinema salahuddin.
Not all investors are the same: Evidence from investor holdings of local-currency debt in Indonesia
Authors: Hosny Amr 
Published: August 2024

This paper examines the global and domestic factors driving different investor holdings of local currency (LC) sovereign debt in Indonesia. Using an autoregressive distributed lag co-integration approach, using monthly data for Indonesia over 2002M12-2022M12, we find that non-resident holdings of LC debt in Indonesia are mostly driven by global factors such as commodity prices and volatility in global bond markets, while domestic investors (such as domestic banks and institutional investors) are mostly driven by higher debt security issuances and Bank of Indonesia (BI) acts as a residual financier under adverse conditions. We also find evidence that foreign investors follow the "benchmark effect" and are attracted by higher domestic yields. Results are mostly robust to different specifications. These results call for a further deepening of the investor base, especially domestic nonbanks, to support market depth and reduce volatility.
Social skills in primary education: Influential variables in intercultural contexts
Authors: Vega Eva Maria Aranda , Fernandez Maria Tome , Marcos Jose Manuel Ortiz 
Published: August 2024

This study examined the most common social skills among elementary school students in an intercultural environment with contextual diversity, taking age, gender and place of birth into consideration. A total of 803 students (aged 6 to 12) were assessed using the previously validated “social skills questionnaire for intercultural students in primary education”. Data were analyzed by descriptive and comparative statistics using the most recent version of SPSS software taking into account sociodemographic variables about social skills. The results indicate that gender exhibits different levels of social skills. Specifically, boys present higher scores than girls to reject and end interactions as well as in the ability to make suggestions to others. Students' social skill development is influenced by their nationality since social interaction within a community and the development of specific social skills are determined by the traditions and customs of every country. It is necessary to consider the diverse profiles of students as priority targets for educational interventions aimed at fostering these types of skills which will contribute to social integration in diverse contexts. The practical implications of this study suggest that educational programs should be adapted to address gender and nationality differences in the development of social skills. Better social and cultural integration in diverse school environments help students interact effectively and develop essential social competencies in a globalized world.
A comprehensive prognostic and immune analysis of LAPTM4B in pan-cancer and Philadelphia chromosome-positive acute lymphoblastic leukemia
Authors: Zhou Hui , Yi Yuyao , He Wei , Zheng Li , Hu Yiguo , Niu Ting 
Published: August 2024

Abstract

Lysosomal-associated protein transmembrane-4 beta (LAPTM4B) protein expression was increased in solid tumors, whereas few studies were performed in hematologic malignancies. We aimed to study the effect of the LAPTM4B gene in pan-cancer and Philadelphia chromosome-positive acute B cell lymphoblastic leukemia (Ph + B-ALL). The differential expression, diagnosis, prognosis, genetic and epigenetic alterations, tumor microenvironment, stemness, immune infiltration cells, function enrichment, single-cell analysis, and drug response across cancers were conducted based on multiple computational tools. Additionally, Ph + B-ALL transgenic mouse model with Laptm4b knockout was used to analyze the function of LAPTM4B in vivo. BrdU incorporation method, flow cytometry, and Witte-lock Witte culture were used to evaluate the roles of LAPTM4B in vitro. We identified that LAPTM4B expression was increased in various cancers, with significant associations with clinical outcomes. LAPTM4B expression correlated with DNA and RNA methylation patterns and was associated with drug resistance. It also influenced the tumor immune microenvironment, with implications for immunotherapy response. In leukemia, LAPTM4B was expressed in stem cells and associated with specific subtypes. Knockout of LAPTM4B impeded B-ALL progression in mice and reduced cell proliferation and caused G0/G1 arrest in vitro. Our study elucidated the role LAPTM4B that promoted the development and progression in Ph + B-ALL. Furthermore, LAPTM4B played a diagnostic, prognostic, and immunological factor.
Assessing bioaccumulation of Pb, Cd, and As in Goats: Impacts of exposure to mine tailings in a polymetallic mining region
Authors: Escorcia-Reynoso Martín Ubaldo , Salgado-Souto Sergio Adrián , Rio-Salas Rafael Del , Talavera-Mendoza Oscar , Bottini-Luzardo María Benedicta , Nuñez-Martínez Guadalupe , Aguirre-Noyola José Luis , Flores Giovanni Hernández 
Published: August 2024

Abstract

Pb, Cd, and As concentrations were measured in blood, edible tissues, urine, feces, and hair samples from goats raised in the vicinity of the abandoned El Fraile mine tailings (Taxco de Alarcón, Mexico) to evaluate the bioaccumulation levels to Pb, Cd, and As. The goats were fed grains, grasses, and sprouts that grew on top of mine tailings and drank from the mine leachate for seven months, reproducing the natural conditions of goats raised around and on top of mine tailings. Blood showed the lowest Pb, Cd, and As concentrations, followed by edible tissues (leg muscle, brain, and lungs) whose concentrations were below Mexican permissible limits (NOM-004-ZOO-1994). However, urine showed higher concentrations of Pb and As, but feces showed even higher concentrations and hair and bezoars exhibited the highest Pb, Cd, and As values. Even though these data suggest that consuming edible tissues does not represent a risk to human health, the high Pb, Cd, and As concentrations in urine, feces, and hair suggest that goats were exposed to chronic poisoning. Additionally, isotope data indicate that Pb determined in blood, urine, and bezoars is related to the remanent mineralization present in the mine tailings, highlighting the hazard that mine tailings represent to the environment and settlers of the region.
Agronomic potential of four cassava (Manihot esculenta Crantz) varieties grown on soils fertilized with cocoa shell compost and chicken dropping compost in Côte d’Ivoire
Authors: KONAN Kouakou Marius , KOUASSI Kouadio Ignace , KOUAME Koffi Honoré , BONY Beket Severin 
Published: August 2024

Abstract

This study was conducted in the Lamto area to evaluate the effect of cocoa shell compost and chicken dropping compost on cassava agronomic variables. The evaluation led to the monitoring of plant development until harvest by measuring some agronomic variables of growth and yield of four varieties of cassava, Alleda agba, Bonoua, Six mois and Yacé each grown on soil fertilized with cocoa shell compost or chicken dropping compost. The experimental design used for this study was a complete randomized block design with 3 replicates. The results revealed that both fertilizers used improved the agronomic variables of cassava. This was reflected in a high number of stems per cutting (3.62). However, the chicken dropping compost gave the best development in stem length for the Six mois variety (121.10 cm). The Bonoua variety gave the largest diameter stems (21.98 mm). This variety gave the highest number of leaves (59) and a wider span (109 cm) with wider (16.75 cm) and longer (17.96 cm) leaves. As for yields, the best was obtained with the Bonoua variety, respectively 27.13 t/ha and 35.26 t/ha with cocoa shell compost and chicken dropping compost. Thus, compost and chicken dropping compost can be recommended to improve cassava productivity in Côte d'Ivoire.
The frequency of cardiovascular events caused by second-generation tyrosine kinase inhibitors may depend on the treatment intensity in patients with chronic myeloid leukemia
Authors: Takahashi Taro , Ohashi Ken-ichi , Ochi Tetsuro , Nasu Kentaro , Nakamura Hiroshi , Harigae Hideo 
Published: August 2024

Abstract

Second-generation tyrosine kinase inhibitors (2GTKIs) have not improved overall survival compared to imatinib due to an increase in cardiovascular events (CVEs) and deaths unrelated to chronic myeloid leukemia (CML). We retrospectively analyzed the incidence of CVEs among CML patients treated with TKIs at our institution and analyzed the risk factors for CVEs.
Method and results:
Fifty-nine newly diagnosed CML patients were included. Imatinib, nilotinib, dasatinib, bostinib, and ponatinib were given to 29, 34, 21, 3, and 4 patients, respectively. The cumulative incidence of CVEs was 16.1% at 5 years and 32.4% at 10 years. According to the univariate analysis, a history of vascular events (p=0.046) and the presence of any risk factor for atherosclerotic disease (p=0.046) were significant, and nilotinib (p=0.053) tended to increase the risk of CVEs. According to the multivariate analysis, nilotinib (p<0.001) and a history of vascular events (p=0.04) were significant risk factors for CVEs, but dasatinib tended to decrease the risk of CVEs (p=0.17, hazard ratio (HR)=0.26, 95% CI 0.04-1.76). The only significant difference between nilotinib and dasatinib was the dose intensity of each TKI (1.0 vs 0.5, p=0.001).
Conclusion: In addition to existing interventions targeting atherosclerotic factors, response-adapted dose adjustments may be necessary to reduce CVEs.
Research on predicting microclimate in pig house based on machine learning algorithms
Authors: Deng Yongtao , Chen Xiwen , Yin Miao , Wang Cong , Dong Pengyu , Xie Zuojie , Sun Jingyan , Wen Jie 
Published: August 2024

Abstract

Temperature, humidity, ammonia, and carbon dioxide have a significant impact on pig production, so this article studies them as a microclimate in a pig house. Predict the microclimate of the pig house and select the algorithm with the best prediction accuracy for the microclimate in the pig house. Most studies on predicting temperature and humidity, ammonia, and carbon dioxide in pig pens only use a single algorithm for prediction, without comparing multiple algorithms on the same dataset to select the algorithm with the highest prediction accuracy. To solve this problem, seven algorithm models based on GRU, LSTM, BP neural network, XGBoost, SVM, Linear regression, and Random forest were constructed. Each model consists of four modules, namely the correlation factor screening module, data preprocessing module, data normalization module, and training and prediction module. The core module is the training and prediction module of the algorithm. The seven algorithm models use corresponding built-in algorithm layers in TensorFlow to learn from historical data, find relationships between data, and then make predictions for microclimates at the next moment. The experimental results indicate that in the microclimate of the pig house mentioned in this article, all four types of environmental factors achieved the best predictive performance in the model based on linear regression algorithm.
The Anti-tumour effect of Aleurites moluccana on HCT-116 Cells
Authors: NEMALA APPALA RAJU , NANDAGOPAL ANITHA 
Published: August 2024

Abstract

Aleurites moluccanus, commonly referred to as the candlenut or candleberry and also known as the Indian walnut, is a flowering tree belonging to the family Euphorbiaceae. The tree produces large, rounded (sub-globose) or slightly two-lobed fruits measuring 4–6 cm in diameter. The initial phase of this study involved phytochemical screening, revealing that the ethanol extract of Aleurites moluccana fruit contains phenolics, terpenoids, tannins, glycosides, and saponins. The presence of these compounds might be responsible for the biological activity. The anticancer activity was tested using HCT-116 cell lines and primary colon epithelial (PCE) cell. Different concentration ranging from 7.8 µg/mL to 1000 µg/mL were tested against each cell lines by MTT assay. Ethanol extract of Aleurites moluccanus fruits showed cytotoxic activity when compared to standard control, Fluorouracil (10 µg/mL). In an MTT-based cytotoxic assay evaluating anticancer activity, the ethanol extract was tested on colorectal cell lines HCT-116 and primary colon epithelial (PCE) cells. Cytotoxicity increased over time, with the highest cytotoxicity observed at 72 hours. The 72-hour treatment exhibits the IC50 of 8.54 µg/mL in HCT-116 cells and 196.72 µg/mL in PCE cells, indicating a potent and time-dependent cytotoxic effect on HCT-116 cells.
Association of early hypocalcemia in preterm neonates with hemodynamically 3 significant patent ductus arteriosus- a retrospective study
Authors: Sheikh Mehwish Sajid , Samson Shoji , Wang Yanzhi , Khan Nabeeha 
Published: August 2024

Abstract

Introduction: We hypothesized that early hypocalcemia in the preterm population affects the 33 timely closure of ductus arteriosus.
Methods: We performed a retrospective chart review of 34 <30 weeks neonates with echocardiographic findings of PDA. The primary outcome was 35 hemodynamically significant patent ductus arteriosus (hsPDA). Secondary outcomes include 36 Grade 3-4 Intra-ventricular hemorrhage and pulmonary hemorrhage.
Results: Out of 290 37 neonates, 108 were identified with early hypocalcemia. The rate of hsPDA in the group with 38 hypocalcemia was 76.4%, whereas the rate of hsPDA in the group without hypocalcemia was 39 74.5% (p=0.71). Incidence of grade 3-4 IVH was 16.0% in the hypocalcemia group and 40 16.8% in the no hypocalcemia group (p = 0.85), and pulmonary hemorrhage is 3.7% in the 41 hypocalcemia group and 8.2% in no hypocalcemia group (p = 0.14).
Conclusion: In this 42 retrospective review, we did not find an association of a hsPDA in a preterm baby with early 43 hypocalcemia.
A Subinhibitory Benzalkonium Chloride Concentration Does Not Affect the Performance of Activated Sludge Semicontinuous Reactors
Authors: Orozco A. M. Ferro , Contreras E. M. 
Published: August 2024

Abstract

In recent years, the use of disinfectants, such as benzalkonium chloride (BAC), has increased. BAC may alter the normal performance of biological wastewater treatment systems and promote resistance to human-use antibiotics. Thus, the present work aimed to study the effect of BAC on the performance of an activated sludge reactor and the change in the resistance of the biomass to BAC and to three antibiotics. Acclimation to BAC lasted two weeks. Then, the biomass could remove BAC within the first four hours. BAC did not affect the performance of the reactor in terms of oxygen consumption (OC), biomass concentration, or carbon removal. According to OC data, BAC was completely oxidized. Thus, BAC could not be a carbon source for biomass growth under the tested conditions. The minimum inhibitory concentration (MIC) of BAC corresponding to native sludge was higher than the tested initial BAC concentration, confirming that a BAC subinhibitory concentration was tested. The acclimation to BAC was also evidenced through the increase in the BAC-MIC. BAC also increased the MIC corresponding to ampicillin. MIC corresponding to cephalexin was higher than the highest tested concentration. Finally, activated sludge was highly sensitive to ciprofloxacin.