bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urticarial Erythema Associated with IgA Myeloma
Authors: Zhang Yan , Morita Eishin , Matsuo Hiroaki , Ueda Daizo , Dekio Satoshi 
Published: July 2014

AbstractWe report a case of atypical urticaria associated with IgA multiple myeloma. A 79‐year‐old man presented with a two‐month history of wheal‐like erythema, which lasted approximately one week without any response to anti‐histamines. Histological examination of a lesion revealed leukocytoclasia as well as perivascular leukocytic infiltration, being consistent with urticarial erythema. Laboratory investigation showed markedly elevated serum IgA concentration and M‐protein in serum protein electrophoresis. A bone marrow examination led to a diagnosis of myeloma. An immunofluorescence study failed to detect any IgA deposit in the lesion. However, the wheal‐like eruptions disappeared when the IgA myeloma was treated and reappeared when it relapsed. We conclude that this long lasting urticaria was the cutaneous manifestation of IgA myeloma.
Erythema Nodosum and Granulomatous Lesions Preceding Acute Myelomonocytic Leukemia
Authors: Anan Takashi , Imamura Tomoyuki , Yokoyama Shigeo , Fujiwara Sakuhei 
Published: July 2014

AbstractA 65‐year‐old female with a one‐month history of painful eruptions on her lower extremities was admitted to our hospital. Histological examination revealed erythema nodosum (EN), and the patient was treated with oral prednisolone (PSL; 20 mg daily). The eruptions subsided in two weeks. One month later, painful reddish eruptions recurred on her upper limbs and abdomen in addition to her lower extremities. A skin biopsy from an abdominal erythematous plaque revealed a non‐caseating granuloma without microorganisms or foreign‐body materials. These eruptions also disappeared with treatment with oral PSL (20 mg daily). No underlying disease, including sarcoidosis, diabetes mellitus, or rheumatoid arthritis, was found. However, five months later, the patient developed conspicuous leukocytosis. She was diagnosed with acute myelomonocytic leukemia (M4) and treated with chemotherapy. After complete remission had been achieved, the EN reappeared, in association with an increase in blastic cells in the bone marrow. Serum levels of tumor necrosis factor‐alpha and interleukin‐1 beta, which are thought to be essential for granuloma formation and induction of EN, were markedly elevated. Physicians must remember that recurrent EN and granulomatous lesions can be a prodromal sign of leukemia.
Clinical Usefulness of a Long‐Term Treatment with an Antithyroid Drug for Psoriasis Vulgaris
Authors: Hasegawa Michiko , Abe Masatoshi , Ohnishi Kazunori , Shoji Chizuru , Ishikawa Osamu 
Published: July 2014

AbstractWe have previously reported that an antithyroid thiourethylene, thiamazole, can bring about significant clinical improvement in patients with psoriasis vulgaris. Although the efficacy of antithyroid thiourethylenes had been reported earlier, few studies have evaluated the safety of its long‐term use. In this study, we aimed to study whether or not long‐term thiamazole administration is complicated by any adverse effects. Eight patients with psoriasis vulgaris were enrolled in this study after informed consent was obtained. Each patient was administered thiamazole orally at 30 mg/day for 12 weeks. Two patients achieved complete clearance of psoriatic lesions. Four patients showed a significant improvement, and two patients did not reach satisfactory improvement. Some adverse effects developed in five patients; serum TSH levels elevated above the normal range in three patients and fell below the normal range in one patient. However, serum free‐ T3 and free‐ T4 levels remained within normal ranges during the treatment in all patients, and none of the patients developed clinical hypothyroidism. This preliminary study suggests that thiamazole administration is an effective and relatively safe treatment for patients with psoriasis vulgaris.
Unilateral Syringoma of the Face Associated with Hyperthyroidism
Authors: Aliagaoglu Cihangir , Atasoy Mustafa , Yildirim Umran , Balik Özgül , Koca Timur , Erdem Teoman 
Published: July 2014

AbstractSyringomas are benign tumors derived from the intraepidermal portion of eccrine sweat ducts. They usually occur on the periobital area, but have also been found on the scalp, forehead, cheeks, axillae, abdomen, extremities, genitalia, and buttocks. We describe a patient with an unusual presentation of unilateral syringoma of the face associated with hyperthyroidism.
A Case of Multiple Cavernous Hemangiomas with Skin and Central Nervous System Involvement
Authors: Ebara Naoki , Asada Hideo , Miyagawa Sachiko 
Published: July 2014

AbstractA 47‐year‐old woman presented with multiple bluish subcutaneous nodules on the trunk and upper extremities. The histological diagnosis of a subcutaneous nodule was cavernous hemangioma. Multiple cavernous hemangiomas were also found in her cerebrum, cerebellum, and medulla oblongata on magnetic resonance imaging examination. We did not detect any mutations in the two loci of the TIE2 gene that have been reported in familial venous malformations.
Postoperative Alopecia in Five Patients after Treatment of Aneurysm Rupture with a Guglielmi Detachable Coil: Pressure Alopecia, Radiation Induced, or Both?
Authors: Lee Won‐Soo , Lee Se‐Won , Lee Sanghoon , Lee Jin Wook 
Published: July 2014

AbstractPostoperative pressure alopecia is an uncommon complication of long anesthetic surgical procedures, typically affecting the occiput and resulting from pressure‐induced tissue hypoxia. Generally, it develops after procedures of long duration, of more than four hours. Most alopecia is transient, but a few cases are permanent. Guglielmi detachable coil (GDC) coiling is a procedure guided by fluoroscopy that fills an intracranial aneurysm. Our cases were characterized by an unusual distribution of alopecia, short duration of procedure, and radiation exposure. The alopecic lesions of our patients were located on the temporal scalp as well as the occipital scalp. The total time of anesthesia was relatively short, two to three hours. During the procedure, these patients were exposed to ionizing radiation (over 2Gy). These cases are different from previous reports in that the duration of the procedure was short, the temporal scalp was affected in addition to the occipital scalp, and the pathology occurred after GDC coiling.
A Comparison of Dermoscopic Features among Lentigo Senilis/Initial Seborrheic Keratosis, Seborrheic Keratosis, Lentigo Maligna and Lentigo Maligna Melanoma on the Face
Authors: Şahin Mustafa Turhan , Öztürkcan Serap , Ermertcan Aylin Türel , Güneş Ali Tahsin 
Published: July 2014

AbstractClinical differentiation of facial lentigo senilis/initial seborrheic keratosis (LS/ISK), seborrheic keratosis (SK), lentigo maligna (LM), and lentigo maligna melanoma (LMM) can be difficult. Dermoscopy improves the diagnoses in pigmented skin lesions (PSLs), but it is not helpful for the sun‐exposed face because of the flat rete ridges without network‐derived features. Therefore, development of new diagnostic criteria for this particular localization is a current issue of dermatology. In this retrospective study, dermoscopic slides of facial pigmented skin lesions of 66 patients referred to two clinics in Turkey were evaluated. Our aim was to determine the reliability of dermoscopy in the differentiation of these entities. The facial PSLs of 66 patients (34 males and 32 females) (median age: 58.2) were photographed with a Dermaphot (Heine, Hersching, Germany) over a five year period from November of 1995 to May of 2000. All of the dermoscopic slides were analysed according to 27 dermoscopic criteria developed by Schiffner et al. This data set contained 22 histologically proven malignant (14 LM, 8 early LMM) and 44 benign (18 SK, 26 LS/ISK) PSLs. In general, asymmetric pigmented follicular openings, dark streaks, slate‐gray streaks, dark globules, slate‐gray globules, dark dots, dark rhomboidal structures, light brown rhomboidal structures, dark homogeneous areas and dark pseudonetworks were statistically significant for malignant growth. On the other hand, milia‐like cysts, pseudofollicular openings, cerebriform structures, light brown globules, light brown dots, light brown homogeneous areas, yellow opaque homogeneous areas, and light brown pseudonetworks were statistically significant for benign growth. This research emphasizes that dermoscopic features on the face differ from criteria used in other locations of the body. Analysis of the data suggests that dermoscopy can be used in the differentiation of LS/ISK, SK, LM and LMM from each other.
A Study of Leprosy Reactions in a Tertiary Hospital in Delhi
Authors: Sharma Neelu , Koranne Ravindra V. , Mendiratta Vibhu , Sharma Ravi Chandra 
Published: July 2014

AbstractA retrospective study of 531 leprosy patients was undertaken to study the profile of reactions in the post Multi‐Drug‐Therapy period in a tertiary hospital in Delhi. BT was the most common group. The prevalence of reactions was found to be 8.09% for the Type 1 and 4.70% for the Type 2 reactions for a male:female ratio of 2.2. The Type 1 reaction was most frequently observed in the BB group followed by BL, BT and LL groups respectively. More than half of the patients had reactions at the time of presentation. In only 39.8% of the patients did reaction follow Multi‐Drug‐Therapy. In 4.5% of the patients with Type 1 reactions (T1R), concomitant infections were noted. The most common presentation of T1R was cutaneous lesions (74.41%) followed by cutaneous lesions and neuritis (53.6%), neuritis alone (12.1%), and only edema of hands and feet (7.31%) respectively. The Type 2 reactions (T2R) presented chiefly as papulo‐nodular (92%) lesions followed by pustulonecrotic (8%) lesions. Associated neuritis was found in 40% and periosteitis and iritis in 8% and 4%, respectively. In 8.6% of the patients with T2R, precipitating factors could be observed. The prevalence of deformities in patients with reaction was 25%, and was more common in females. Deformities were observed in 23.25% of the T1R patients and 28% of the T2R patients.
β‐Mannosidosis with Angiokeratoma Corporis Diffusum
Authors: Suzuki Nuiko , Konohana Izumi , Fukushige Tomoko , Kanzaki Tamotsu 
Published: July 2014

Abstractβ‐mannosidosis is a lysosomal disorder which is caused by a deficiency of β‐mannosidase. This disorder was first described in goats. Twelve human cases have already been reported. We present the first case in Japan in whom the diagnosis was reached from angiokeratoma corporis diffusum. Futhermore, mental retardation, hearing loss, and renal failure were also detected. Pseudoxanthoma elasticum was also present, but whether it is a complication of β‐mannosidosis or not remains unknown. The activity level of β‐mannosidase in the patient's plasma was only 2% of the normal range, while that in the patient's mother was 40%. We suggest that β‐mannosidosis should be one of the differential diagnoses when lysosomal enzyme disorders are suspected in cases of angiokeratoma corporis diffusum.
Delta‐Aminolevulinic Acid‐Based Photodynamic Therapy for Acne on the Body
Authors: Kimura Makoto , Itoh Yoshiyasu , Tokuoka Yoshikazu , Kawashima Norimichi 
Published: July 2014

AbstractIntractable acne on the body was clinically treated with photodynamic therapy (PDT) combining oral administration of δ‐aminolevulinic acid (ALA) with polychromatic visible light from a metal halide lamp. The total number of body acne patients was 51. A 10 mg/kg B.W. of ALA was administered to the patients, and the acne lesions were exposed to the light emitted from the metal halide lamp. The wavelengths of the light ranged from 540 to 800 nm. The diameter of the irradiated area and the irradiating distance from the lamp were 100 mm and 130 mm, respectively. Under the irradiation conditions, the total fluence rate and the energy‐density uniformity of the light were 69.2 mW/cm2 and 11.5%. The total light energy dose in one session was 60–80 J/cm2 for the body. All patients underwent two sessions of PDT and received no other treatments after PDT or during the follow‐up period. The interval between the two PDT sessions was 2–4 weeks. The physician's clinical assessment scores as worsened, unchanged, improved, and markedly improved were 0 (0%), 4 (7.8%), 16 (31.4%), and 31 (60.8%) patients, respectively. Adverse effects of very slight discomfort, burning, and stinging were reported during the irradiation. The blood tests of patients before and after oral administration of ALA demonstrated that no liver dysfunction occurred in this study with ALA dosages within 10 mg/kg B.W. Consequently, orally administered ALA‐PDT with a metal halide lamp was considered to be effective for treatment of acne on the body.
A Cross‐Sectional Analysis of Quality of Life in Japanese Acne Patients Using the Japanese Version of Skindex‐16
Authors: Hayashi Nobukazu , Higaki Yuko , Kawamoto Kyoko , Kamo Toshiko , Shimizu Satoru , Kawashima Makoto 
Published: July 2014

AbstractWe measured the quality of life of Japanese patients with acne using the Japanese version of Skindex‐16, a semantically equivalent and validated translation of the original version produced by Chren et al. A total of 210 acne patients were enrolled in this study. The results showed that patients with acne experienced more severe emotional effects from their skin disease than functional or symptomatic effects. The scores for emotional aspects were related to the severity of the patients' acne following a prescribed scale, but the scores were high even when the patients only had a few comedones. Akaike's information criterion showed that the scores for symptoms were related to the severity of the patients' acne, and the patients' emotions were related to the interval between clinic visits. To improve patients' quality of life, treatment of comedones should be fully respected. In addition, dermatologists should encourage patients to visit clinics regularly to help them improve the emotional aspects of their quality of life.
The Significance of Serum Nitric Oxide Levels in Behçet's Disease and Recurrent Aphthous Stomatitis
Authors: Yildirim Mehmet , Baysal Vahide , Inaloz H. Serhat , Doguc Duygu 
Published: July 2014

AbstractBehçet's disease (BD) is an inflammatory multisystem disorder characterized by recurrent oral and genital aphthous ulcers, arthritis, uveitis, and thrombophlebitis; it can involve several organs. However, recurrent aphthous stomatitis (RAS) can be seen without a confirmed diagnosis of BD. Moreover, there is no way of predicting whether a patient with RAS will develop BD. Nitric oxide (NO) is a free radical synthesized from L‐arginine by one of the family of nitric oxide synthase (NOS) enzymes. Increased production of NO during several inflammatory and infectious processes has been recently postulated. Our aim was to investigate the serum NO levels in patients with active and inactive BD and RAS. Forty‐six patients with BD, 30 patients with RAS and 30 healthy controls were enrolled in the study. The patients with BD were separated into two groups: clinically active (n=24) and inactive (n=22). A blood sample was collected from all subjects in order to determine their serum NO levels. In patients with active BD, higher serum levels of NO metabolite were found in comparison with patients with inactive BD, in patients with RAS, or healthy controls (p<0.05). We also found higher serum NO metabolite levels in patients with RAS than in healthy controls (p<0.05). In patients with inactive BD, statistically significant higher levels of serum NO levels were found in comparison with the control group (p<0.05). However, we found no statistically significant difference between the patients with inactive BD and RAS, which indicated that inactive BD cannot be distinguished from RAS by serum NO levels. We conclude that serum NO levels may be an important marker for estimating the severity of BD. However, further studies are needed to confirm our findings.
Subungual Glomus Tumor: Clinical Manifestations and Outcome of Surgical Treatment
Authors: Moon Sang Eun , Won Jong Hyun , Kwon Oh Sang , Kim Jeong Aee 
Published: July 2014

AbstractSurgical excision is the treatment of choice for subungual glomus tumor. However, the anatomical location has inherent difficulties. We report the outcomes of surgical treatments for subungual glomus tumor. Sixteen patients, who were seen over an eight‐year period (1995–2003) and confirmed as gloums tumor by histopathologic examination were reviewed. The most common subjective symptom was pain induced by contact in 81%. The tumor presented as a discolorated spot or subungual nodule and 38% of tumors were acccompanied with nail dystrophy. All tumors showed discolorated spots or subungual nodules. As shown in the Table 2, the dystrophic nail change was found in 38% of tumors. Differently oriented incisions were made according to the location of tumor, matrix, or bed. The original nail plate was restored in eight patients. Thirteen patients (81%) had cosmetically excellent nail plates, and three patients (19%) had partial distal splits of nail plates. There was no recurrence. Our series suggests that a transungual approach with nail avulsion and an incision selected according to the tumor location can produce an excellent outcome with minimal postoperative complications. Dressing with a trimmed nail plate may also be beneficial in managing the wound and preventing postoperative nail deformity.
Unsuccessful Treatment of Extragenital Lichen Sclerosus with Topical 1% Pimecrolimus Cream
Authors: Arican Ozer , Ciralik Harun , Sasmaz Sezai 
Published: July 2014

AbstractLichen sclerosus most commonly affects the anogenital region. Spreading into the extragenital regions is rare, and its course is most commonly asymptomatic. Women have been reported to be affected 6 to 10 times more often than men. The etiology of lichen sclerosus is still unknown. The disease is characterized by ivory‐white atrophic plaques, and no treatment ensuring complete recovery is available. T‐cells are also involved in its pathogenesis. Pimecrolimus is a topical inhibitor of T‐cells. In the present paper, we present a male patient with lichen sclerosus located only in extragenital regions and report an unsuccessful outcome of treatment with pimecrolimus 1% cream administered topically twice a day for 16 weeks.
Anti‐Inflammatory Effects of Tacalcitol (1,24(R)(OH)2D3, TV‐02) in the Skin of TPA‐Treated Hairless Mice
Authors: Sato Hiroaki , Nakayama Yasunori , Yamashita Chizuru , Uno Hiroshi 
Published: July 2014

AbstractTacalcitol (1,24(R)(OH)2D3, TV‐02) inhibited the TPA‐induced inflammatory cell infiltration (largely neutrophils) histopathologically and myeloperoxidase (MPO) activity dose‐dependently. Tacalcitol inhibited the mRNA expression and protein production of TPA‐induced macrophage inflammatory protein‐2 (MIP‐2) and KC, the functional analogue of human interleukin (IL)‐8, in the skin. Immunohistochemical staining of the TPA‐applied skin revealed that mast cells expressed MIP‐2, whereas KC was observed in keratinocytes, fibroblasts and outer root sheath of hair follicles. Furthermore, tacalcitol inhibited TPA‐induced mast cell degranulation 24 hr after application without influence on the total number of mast cells. In this study, tacalcitol was found to have an inhibitory effect on cutaneous inflammation such as inhibition of neutrophil infiltration, MIP‐2 and KC production, and mast cell degranulation in TPA‐treated hairless mice. These results suggest that tacalcitol modulates cutaneous inflammation as well as keratinocyte proliferation and differentiation, and the inhibitory effect of tacalcitol on cutaneous inflammation may contribute to clinical the effectiveness in the treatment of psoriasis.
Two Cases of Subcutaneous Trichoblastoma
Authors: Takai Toshihiro , Tsuji Masayuki , Ueda Masato 
Published: July 2014

AbstractThis report concerns two Japanese women, 54 and 53 years old, with trichoblastoma. Histopathologically, these neoplasms were mainly composed of follicular germinative cells with fibrotic stroma. One of them was a giant lesion, but the other was small. Because both lesions were located in the subcutis, we termed them subcutaneous trichoblastoma.
A Case of Polypoid Clear Cell Acanthoma on the Scrotum
Authors: Kawaguchi Hiroshi , Tatewaki Satoko , Takeuchi Mizue 
Published: July 2014

AbstractA red nodule appeared on the left side of the scrotum of a 37‐year‐old Japanese man and slowly grew for four years. When he first visited us, it was 5 mm in diameter, polypoid shaped, and had a smooth and slightly moist surface. Histologically, acanthosis, parakeratosis, and dilated blood vessels were seen in the upper dermis. In higher magnification, the thick epidermis consisted of tumor cells with slightly enlarged nuclei and pale cytoplasm, and neutrophils were also seen among the tumor cells. The cytoplasm of the tumor cells was stained with periodic‐acid‐Schiff (PAS), and the positive reaction was digested by diastase. There has been no previous report of polypoid clear cell acanthoma in Japan, and only a few reports from the rest of the world. In addition, clear cell acanthoma arising on the scrotum is particularly unusual.
Squamous Cell Carcinoma in Untreated Lichen Sclerosus of the Penis: A Rare Complication
Authors: Kumaran M. Sendhil , Kanwar Amrinder Jit 
Published: July 2014

AbstractLichen sclerosus et atrophicus (LSA) is an uncommon disease of the skin and mucosae of either sex. Apart from a number of complications, SCC developing from a lesion of LSA in males is rare, although it is well known in females. We report two cases recently seen by us to alert clinicians of this potentially fatal complication in males.
Diabetes and Hepatitis Frequency in 140 Lichen Planus Cases in Çukurova Region
Authors: Denli Y. Gül , Durdu Murat , Karakaş Mehmet 
Published: July 2014

AbstractThe aim of the present study was to determine the Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and diabetes mellitus (DM) frequencies in lichen planus (LP) cases in our region. We performed a retrospective review of records from all cases that were diagnosed with LP at the our department between 1997 and 2002. The results were compared with the control group (any type of dermatosis other than LP). The 260 LP cases included 108 (41.5%) males and 152 (58.5%) females aged between 5 and 78 years. The clinical distribution of the lesions were 127 (48.8%) with skin lesions and 133 (51.2%) with oral mucosal lesions. The duration of disease ranged from 1 to 240 months. In 140 of 260 LP cases, hepatitis serology and pre‐prandial blood glucose were examined. We found HBV positivity in 24 (17.1%) cases, Anti‐HCV positivity in 7 (5%) cases, and DM in 22 (15.7%) cases. The control group included 116 (41.4%) males and 164 (58.6%) females. Their ages ranged between 10 and 82 years. In this group, we found HBV positivity in 20 (7.1%), Anti‐HCV positivity in 4 (1.4%), and DM in 20 (7.1%) cases. We believe that the co‐association of LP with HCV is significant and this co‐association ratio indicates variance depending on clinical attributes of the lesions and racial characteristics of the patients. Although we found co‐associations between HBV and LP or DM and LP, we believe that further studies are necessary to determine if they are significant.