bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn 
Published: June 2015

Abstract
The use of advanced imaging technologies for the identification of pancreatic cysts has become widespread. However, accurate differential diagnosis between mucinous cysts (MC) and nonmucinous cysts (NMC) consisting of pseudocysts (NMC1) and nonmucinous neoplastic cysts (NMC2) remains a challenge. Thus, it is necessary to develop novel biomarkers for the differential diagnosis of pancreatic cysts. An integrated proteomics approach yielded differentially expressed proteins in MC that were verified subsequently in 99 pancreatic cysts (21 NMC1, 41 NMC2, and 37 MC) using a method termed GeLC-stable isotope dilution-multiple reaction monitoring-mass spectrometry (GeLC-SID-MRM-MS) along with established immunoassay techniques. We identified 223 proteins by nanoscale liquid chromatography coupled to tandem mass spectrometry (nano LC/MS-MS). Nine candidate biomarkers were identified, including polymeric immunoglobulin receptor (PIGR), lipocalin 2 (LCN2), Fc fragment of IgG-binding protein (FCGBP), lithostathine-1-alpha (REG1A), afamin (AFM), chymotrypsin C (caldecrin; CTRC), amylase, alpha 2B (pancreatic; AMY2B), lectin, galactoside-binding, soluble, 3 binding protein (LGALS3BP), and chymotrypsin-like elastase family, member 3A (CELA3A), which were established as biomarker candidates for MC. In particular, we have shown that a biomarker subset, including AFM, REG1A, PIGR, and LCN2, could differentiate MC not only from NMC (including NMC1) but also from NMC2. Overall, the MS-based comprehensive proteomics approach used in this study established a novel set of candidate biomarkers that address a gap in efforts to distinguish early pancreatic lesions at a time when more successful therapeutic interventions may be possible. Cancer Res; 75(16); 3227–35. ©2015 AACR.
Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication
Authors: Chaoul Nada , Fayolle Catherine , Desrues Belinda , Oberkampf Marine , Tang Alexandre , Ladant Daniel , Leclerc Claude 
Published: June 2015

Abstract
The metabolic sensor mTOR broadly regulates cell growth and division in cancer cells, leading to a significant focus on studies of rapamycin and its analogues as candidate anticancer drugs. However, mTOR inhibitors have failed to produce useful clinical efficacy, potentially because mTOR is also critical in T cells implicated in immunosurveillance. Indeed, recent studies using rapamycin have demonstrated the important role of mTOR in differentiation and induction of the CD8+ memory in T-cell responses associated with antitumor properties. In this study, we demonstrate that rapamycin harms antitumor immune responses mediated by T cells in the setting of cancer vaccine therapy. Specifically, we analyzed how rapamycin affects the antitumor efficacy of a human papilloma virus E7 peptide vaccine (CyaA-E7) capable of eradicating tumors in the TC-1 mouse model of cervical cancer. In animals vaccinated with CyaA-E7, rapamycin administration completely abolished recruitment of CD8+ T cells into TC-1 tumors along with the ability of the vaccine to reduce infiltration of T regulatory cells and myeloid-derived suppressor cells. Moreover, rapamycin completely abolished vaccine-induced cytotoxic T-cell responses and therapeutic activity. Taken together, our results demonstrate the powerful effects of mTOR inhibition in abolishing T-cell–mediated antitumor immune responses essential for the therapeutic efficacy of cancer vaccines. Cancer Res; 75(16); 3279–91. ©2015 AACR.
Analysis of Inflammatory and Anemia-Related Biomarkers in a Randomized, Double-Blind, Placebo-Controlled Study of Siltuximab (Anti-IL6 Monoclonal Antibody) in Patients With Multicentric Castleman Disease
Authors: Casper Corey , Chaturvedi Shalini , Munshi Nikhil , Wong Raymond , Qi Ming , Schaffer Michael , Bandekar Rajesh , Hall Brett , van de Velde Helgi , Vermeulen Jessica , Reddy Manjula , van Rhee Frits 
Published: June 2015

Abstract
Purpose: Siltuximab (IL6 antibody) is approved for the treatment of multicentric Castleman disease (MCD). Effects of IL6 inhibition on the inflammatory milieu accompanying MCD have not been characterized.
Experimental Design: Trends in inflammatory- and anemia-associated markers, measured over the course of a placebo-controlled study of siltuximab (11 mg/kg q3w) in patients with MCD (n = 79), were characterized.
Results: Baseline IL6 and C-reactive protein (CRP) levels were significantly correlated (r = 0.708; P &lt; 0.0001). CRP levels decreased (median, 92%) by cycle 1 day 8 (C1D8), remaining suppressed during siltuximab treatment while remaining stable in the placebo group. There were no associations between baseline CRP or IL6 and MCD symptom burden, histologic subtype, ethnicity, maximum CRP decrease, and response parameters. A hemoglobin response (change ≥ 15 g/L at week 13) was observed with siltuximab (61%; P = 0.0002). Median hepcidin decrease from baseline at C1D8 with siltuximab was 47% versus median 11% increase with placebo. Maximum post-baseline changes in hepcidin levels among siltuximab recipients were correlated with maximum changes for hemoglobin (r = −0.395; P = 0.00607), total iron-binding capacity (TIBC; r = −0.354; P = 0.01694), and ferritin (r = 0.599; P = 0.0001). Greater median changes from baseline in ferritin, hemoglobin, and TIBC were observed in anemic siltuximab-treated patients.
Conclusions: IL6 neutralization with siltuximab resulted in sustained CRP suppression and improvement of anemia, in part, by hepcidin pathway inhibition. Clin Cancer Res; 21(19); 4294–304. ©2015 AACR.
SISTEMA DE INFORMAÇÃO GEOGRÁFICA COMO MEIO DE IDENTIFICAÇÃO DOS NÍVEIS DE RUÍDO LOCAIS NO CENTRO URBANO DE MARINGÁ/PR
Authors: Prudencio Erivelto Alves , Soares Paulo Fernando , De Oliveira Roney Berti , Janeiro Vanderly 
Published: June 2015

<p>Neste trabalho, foram analisados 12 pontos referentes aos níveis de ruído de tráfego na área urbana, na porção central do município de Maringá-PR. Os dados foram coletados no período matutino e tratatos para obtenção dos níveis de pressão sonora L10, L90, bem como o Traffic Noise Index (TNI). A partir destes dados, obteve-se através da análise estatística o comportamento das variáveis mais explicativas para carro, moto, caminhão e ônibus. Em seguida foi analisada distribuição espacial pelo método da Krigagem, utilizando os softwares SPRING e SURFER 10, dos níveis de ruído durante o intervalo de tempo avaliado conforme a Norma Técnica NBR 10.151 (2000). As informações obtidas através da análise dos dois níveis de ruído, bem como do índice, permitiu comparar as regiões de maior concentração de comércio e serviços com áreas de parques na região de estudo. Desta forma, foi possível verificar que, durante os cinco minutos de medição, a população está exposta 100% do tempo a ruídos acima do definido como permitido.</p>
CARACTERÍSTICAS DO CLIMA URBANO EM PRESIDENTE PRUDENTE/SP A PARTIR DE DADOS DE TEMPERATURA E UMIDADE RELATIVA DO AR E TÉCNICAS DE SENSORIAMENTO REMOTO
Authors: Cardoso Renata Dos Santos , Amorim M. C. C. T. 
Published: June 2015

<em><em><em><em>O processo de urbanização modifica o clima local, pois as formas materiais presentes na cidade, bem como as atividades que nela se desenvolvem, provocam alterações nos elementos do clima como a temperatura, umidade relativa do ar, direção e velocidade do vento. Destes, a temperatura tem se destacado nos estudos sobre o clima urbano, pois as características da área urbana promovem seu aumento tanto no ar quanto nos alvos da superfície. Nesse sentido, este estudo teve como objetivo identificar as alterações térmicas intraurbanas e suas magnitudes, relacionando-as com os tipos de uso e ocupação da superfície do solo no município de Presidente Prudente-SP. Para tanto, realizaram-se análises das diferenças térmicas e higrométricas entre o urbano e o rural, em um mês representativo do verão (fevereiro), e a verificação da temperatura da superfície através do sensoriamento remoto no infravermelho termal. Os resultados apresentaram que os tipos de tempo, assim como as características da superfície foram responsáveis pelas maiores ou menores diferenças entre a área urbana e a rural, o que demonstra a importância de se adequar o planejamento urbano às características do ambiente local. <strong><br /> </strong></em></em></em> </em>
Mobile Radiosonde Deployments during the Mesoscale Predictability Experiment (MPEX): Rapid and Adaptive Sampling of Upscale Convective Feedbacks
Authors: Trapp Robert J. , Stensrud David J. , Coniglio Michael C. , Schumacher Russ S. , Baldwin Michael E. , Waugh Sean , Conlee Don T. 
Published: June 2015

Abstract
The Mesoscale Predictability Experiment (MPEX) was a field campaign conducted 15 May through 15 June 2013 within the Great Plains region of the United States. One of the research foci of MPEX regarded the upscaling effects of deep convective storms on their environment, and how these feed back to the convective-scale dynamics and predictability. Balloon-borne GPS radiosondes, or “upsondes,” were used to sample such environmental feedbacks. Two of the upsonde teams employed dual-frequency sounding systems that allowed for upsonde observations at intervals as fast as 15 min. Because these dual-frequency systems also had the capacity for full mobility during sonde reception, highly adaptive and rapid storm-relative sampling of the convectively modified environment was possible. This article documents the mobile sounding capabilities and unique sampling strategies employed during MPEX.
The politics of fiscal consolidation in the Netherlands: mainly compromising but hesitant attempts at targeted priority-setting
Authors: Kickert Walter J.M. 
Published: June 2015

This article analyses fiscal consolidation in the Netherlands, especially the politics of consolidation and cutbacks. We discuss the contents of the consolidation measures, and the political decision-making processes leading up to the measures. The analysis of the political decision-making focuses on the characteristics and stages of the decision-making. The three stages of fiscal consolidation analysed in this article – the October 2010 coalition agreement, the April 2012 spring agreement, and the October 2012 coalition agreement – show a gradually mounting recognition of the necessity for serious cutbacks. Decision-making was mainly characterized by consensual compromising, that is, incremental, across-the-board, cheese-slicing measures. However, in later stages of the fiscal crisis, hesitant attempts were made at targeted political priority-setting. Points for practitioners This article’s main focus is on the political decision-making leading up to cutback measures, whether the decisions were mainly incremental, across-the-board, cheese-slicing, or whether targeted, selective cutbacks based on political priority-setting also occurred. It turns out that hesitant attempts of the latter type were indeed made. After a while some fundamental reconsiderations did seep through in Dutch consensus politics. Another key point is that budget discipline played a dominant role in the government’s fiscal consolidation. The economic experts of the Ministry of Finance, Central Planning Bureau, etc. had a major influence on the financial frames of the cutbacks.
Medical Evidence and Expertise in Abortion Jurisprudence
Authors: Ahmed Aziza 
Published: June 2015

For another thing, the division of medical opinion about the matter at most means uncertainty, a factor that signals the presence of risk, not its absence. That division here involves highly qualified knowledgeable experts on both sides of the issue.—Stenberg v. Carhart, 20001While we find no reliable data to measure the phenomenon, it seems unexceptionable to conclude some women come to regret their choice to abort the infant life they once created and sustained.—Gonzales v. Carhart, 20072
Laryngeal Verrucous Carcinoma
Authors: Dubal Pariket M. , Svider Peter F. , Kam David , Dutta Rahul , Baredes Soly , Eloy Jean Anderson 
Published: June 2015

ObjectiveVerrucous carcinoma of the larynx (VCL) is a rare entity with reportedly favorable prognosis. Current analyses are limited primarily to case reports and case series, thus making a population‐based analysis useful in characterizing frequency, incidence, and survival trends to guide clinical diagnosis and decision making.Study DesignAnalysis of the National Cancer Institute’s SEER (Surveillance, Epidemiology, and End Results) database.MethodsCases of VCL diagnosed between 1973 and 2011 were searched in the SEER database. Analysis was carried out with respect to patient demographics, tumor characteristics, incidence, treatment modality, and survival.ResultsIn sum, 516 patients with VCL were identified. Males composed 88.4% of cases. Whites accounted for 88.4% of cases, with 8.1% of cases occurring in black patients. Most cases (79.7%) arose in the glottis, a statistically significant predilection when compared with other laryngeal malignancies (P <. 0001). Incidence of VCL decreased from 2000 to 2011, with an annual percent change of −5.4%. Overall 1‐, 5‐, and 10‐year disease‐specific survival for VCL was 97.5%, 88.0%, and 77.4%, while 1‐, 5‐, and 10‐year relative survival was 98.1%, 85.5%, and 74.2%, respectively. Surgery seemed to confer better prognosis when compared with other treatment modalities.ConclusionsThis large population‐based analysis of VCL demonstrates that this entity has a good prognosis, arises in the glottis, and is decreasing in incidence. Five‐year survival seems highest when surgery is utilized. However, this finding may be subject to selection bias in high‐stage lesions.
Coronary artery dimensions: Iranian population versus Indo-Asians and Caucasians
Authors: Ghaffari Samad , Mehdizadeh-Lame Mohammad-Bagher , Sepehrvand Nariman , Aslanabadi Naser , Sohrabi Bahram , Separham Ahmad , Jamshidi Peiman 
Published: June 2015

Background The dimensions of the coronary arteries have been shown to vary among ethnic groups. There are no data available regarding the normal size of coronary arteries in Iranians. This study aimed to investigate normal coronary artery dimensions in a Northwestern Iranian population and to compare it with pooled data of Indo-Asians and Caucasians in previous studies. Methods The study included 200 adults with suspected coronary disease who were referred for elective coronary angiography between June 2012 and March 2013 and were found to have normal epicardial flow in the coronary arteries. Quantitative coronary angiography was carried out on the longest atheroma-free part of the proximal segment of each coronary artery in all patients. Two Indo-Asian and Caucasian groups were selected and pooled for comparison with the available reports on individuals without coronary artery disease. Results The mean diameters of the left main coronary artery, proximal left anterior descending artery, proximal left circumflex, and proximal right coronary artery were 4.58 ± 0.80, 3.69 ± 0.64, 3.37 ± 0.73, and 3.47 ± 0.68 mm, respectively. The dimensions of the proximal part of the left main coronary artery and right coronary artery were significantly greater in the Northwestern Iranian population compared to the pooled Caucasian group. This difference was maintained even after correction for body surface area. Conclusion Our data indicate larger coronary diameters in the Iranian population compared to Caucasians or South-Asians. Hence the high prevalence of coronary artery disease in Iran cannot be explained by coronary dimensions.
Movement of mitral fibrous components in an isolated porcine working heart model
Authors: Tamenishi Akinori , Araki Yoshimori , Saito Shunei , Oshima Hideki , Ueda Yuichi , Usui Akihiko 
Published: June 2015

Background There is little research regarding the movement of mitral fibrous components. We analyzed changes in mitral fibrous components in normal and deteriorated isolated working swine hearts. Methods In 5 swine hearts, 6 sonomicrometry transducers were placed around the mitral annulus and 2 in the papillary muscle tip. During the working cycle, we evaluated the annular dimension and calculated the contraction range and contraction ratio during the cardiac cycle in normal and deteriorated modes. Results The transverse (24.5 ± 2.3 vs. 27.4 ± 2.4 mm) and posterior longitudinal diameter (18.3 ± 7.0 vs. 22.5 ± 5.5 mm) increased significantly in deteriorated mode. The contraction range in transverse (1.8 ± 0.6 vs. 0.8 ± 0.7 mm) and posterior longitudinal (1.6 ± 0.6 vs. 0.8 ± 0.3 mm) diameters decreased significantly in deteriorated mode. The contraction range of the strut chordae was less than 1.0 mm in both modes, with no significant differences. The contraction ratio of the anterior strut chordae was significantly reduced in deteriorated mode (3.2 ± 1.1% vs. 2.2 ± 1.1%). The contraction ratio of the annulus was significantly lower in deteriorated mode with respect to transverse (6.9 ± 2.1% vs. 2.9 ± 2.9%) and longitudinal (13.3 ± 4.5% vs. 8.6 ± 5.1%) diameters. Conclusions In the deteriorated hearts, the mitral annulus was dilated and contractility decreased. The length of the strut chordae differed 1 mm between the deteriorated and normal modes; however, the contraction ratio of the anterior chordae during the cardiac cycle was reduced, indicating increased stretching.
Efficacy of minimally invasive surgery in diagnosis of interstitial lung disease
Authors: Bagheri Reza , Haghi Seyed Ziaollah , Attaran Davood , Hashem Asnaashari Amir Mohammad , Basiri Reza , Rajabnejad Ata'ollah 
Published: June 2015

Objective This study aimed to evaluate the efficacy and safety of video-assisted thoracic surgery in reaching a specific diagnosis in patients with interstitial lung disease. Methods Thirty-eight patients with interstitial lung disease (19 males, 19 females; mean age 47.73 years) who had undergone video-assisted thoracic surgery at Ghaem Hospital, Mashhad, Iran, between 2010 and 2013 were evaluated retrospectively in this study. Preoperative evaluations including cardiac and pulmonary assessments were performed. Data were recorded in forms prepared for this study and included age, sex, symptoms, imaging findings, operation duration, chest drain withdrawal time, postoperative hospital stay, hospital mortality, and specific diagnosis of the disease. Results The most common symptom was dyspnea (38 patients, 100%). The most common computed tomography finding was a reticular pattern (30 patients, 78.94%). Surgery complications included persistent air leak in 3 (7.9%) cases and wound infection in 2 (5.26%). There was no hospital death and no need for reoperation. The average of operative time was 50 min. The mean time for chest drain withdrawal and postoperative hospitalization was 4 and 5 days, respectively. The most common diagnoses were usual interstitial pneumonia in 9 (23.68%) patients and sarcoidosis in 6 (15.78%). A specific diagnosis was not reached in 2/38 (5.26%) patients after video-assisted thoracic surgery. Conclusion Video-assisted thoracic surgery is a highly effective and safe method for establishing a specific diagnosis in patients with interstitial lung disease.
Cross-cultural verification of the EORTC QLQ-C15-PAL questionnaire in mainland China
Authors: Zhang Lei , Wang Ning , Zhang Jing , Liu Jiahao , Luo Zhiqin , Sun Weilin , Woo Stephanie Mu-Lian , Chen Chujun , Zhang Kai , Miller Adam R , Guo Hui , Zhang Xueying , Wang Changli 
Published: June 2015

Background: Simplified by European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire Core 30 (QLQ-C30), EORTC Quality-of-Life Questionnaire Core 15 Palliative Care (QLQ-C15-PAL) is specifically applied to evaluating palliative care patients’ quality of life. Aim: This study examined cross-cultural adaptability and validity of QLQ-C15-PAL for evaluating quality of life of palliative care patients with advanced cancer in mainland China. Participants and design: From May to October 2013, 243 palliative care patients in Tianjin Cancer Hospital completed the EORTC QLQ-C30. We extracted QLQ-C15-PAL data for analysis. Physicians completed the Eastern Cooperative Oncology Group Performance Status score and mental state assessment for each patient. Results: A total of 243 patients completed the study. The compliance rate was high, with missing rate for each item ranging from 0% to 2.1%. In addition to emotional function, the remaining dimensions demonstrated a high reliability (Cronbach’s alpha > 0.7). Whether we divided patients into two groups according to their Eastern Cooperative Oncology Group Performance Status or divided patients into three groups according to mental status, both sets of results showed significant differences in QLQ-C15-PAL subscale scores ( p < 0.05), indicating that the QLQ-C15-PAL scale could be used to distinguish between the aforementioned subgroups. Overall quality of life was moderately correlated with fatigue ( r = −0.406) but weakly correlated with other subscales. The proportion of variance ( R2) ranged from 0.848 to 0.903, which showed that QLQ-C15-PAL subscale scores explained between 84.8% and 90.3% of the original QLQ-C30 score distribution. Conclusion: The Chinese version of the EORTC QLQ-C15-PAL questionnaire has high reliability and validity and is therefore suitable for clinical use in China to determine health-related quality of life in Chinese patients with advanced cancer.
Serum neuron specific enolase – a novel indicator for neuropsychiatric systemic lupus erythematosus?
Authors: Hawro T , Bogucki A , Krupińska-Kun M , Maurer M , Woźniacka A 
Published: June 2015

Objective Neuropsychiatric (NP) lupus, a common manifestation of systemic lupus erythematosus (SLE), is still insufficiently understood, in part, because of the lack of specific biomarkers. Neuron specific enolase (NSE), an important neuronal glycolytic enzyme, shows increased serum levels following acute brain injury, and decreased serum levels in several chronic disorders of the nervous system, including multi infarct dementia, multiple sclerosis and depression. The aim of the study was to evaluate serum NSE levels in SLE patients with and without nervous system involvement, and in healthy controls, and to assess the correlation of NSE serum levels of patients with neuropsychiatric systemic lupus erythematosus (NPSLE) with clinical parameters. Methods The study comprised 47 SLE patients and 28 controls. SLE activity was assessed using the Systemic Lupus Activity Measure (SLAM). A neurologist and a psychiatrist examined all patients. NP involvement was diagnosed according to strict NPSLE criteria proposed by Ainiala and coworkers, as modification to American College of Rheumatology (ACR) nomenclature and case definitions. NSE serum levels were determined by use of an immunoassay. Results Mean NSE serum concentrations in patients with NPSLE were significantly lower than in non-NPSLE patients (6.3 ± 2.6 µg/L vs. 9.7 ± 3.3 µg/L, p < 0.01) and in controls (8.8 ± 3.3 µg/L, p < 0.05). There were significant negative correlations between NSE serum levels and SLE activity ( r = −0.42, p < 0.05) and the number of NPSLE manifestations diagnosed (−0.37; p = 0.001). Conclusion Decreased serum concentrations of NSE may reflect chronic neuronal damage with declined metabolism of the nervous tissue in patients with NPSLE.