bluuebunny/crossref_metadata_2025_split huggingface dataset:
An automated method for thrombocyte counting in capillary microsamples
Authors: Boesen Caroline Vasard , Christensen Vibeke Staun , Jensen Klaus Rosenkilde , Hansen Anja Reinert , Hviid Claus Vinter Bødker 
Published: August 2024

AbstractIntroductionWe aimed to develop an automated, low‐volume method for thrombocyte counting in capillary blood using the Sysmex predilution (PD) mode.MethodsMicrosamples were prepared by resuspension of 50 μL blood in 300 μL DCL CellPack. Thrombocyte counting was done in the impedance (PLT‐I) and fluorescence (PLT‐F) channels. The imprecision and bias was evaluated in >394 microsamples from adult blood. Preanalytical factors (skin‐piercing, storage, and transportation in our pneumatic tube system) was assessed, and studies on pediatric microsamples were made for comparison. The improvement in analytical quality and turnaround time was examined.ResultsFor PLT‐F, the imprecision was 1.1%–3.7%, and the bias was 10.1% (95% CI: 8.8–11.3). After skin‐piercing, the bias was 8.1% (95% CI: 5.6–10.6) and the imprecision 1.9% (95% CI: 1.3–2.5). Thrombocyte counts kept stable after 4 h at room temperature (94.8% [95% CI: 93.2–96.4]) and after pneumatic tube transportation [6.7% (95% CI: 4.8–8.6)]. The bias of the PD mode for pediatric microsamples was 13.0% (95% CI: −8.4–34.4) in the PLT‐F channel. The automated method had a considerably lower imprecision than the existing manual thrombocyte counting method and reduced turnaround times.ConclusionThe automated microsample method offers a low‐volume alternative for measurement of thrombocytes. The method appears useful also in pediatric samples.
Happiness across the borders—A cross‐sectional study among patients with psoriasis and atopic dermatitis in Europe
Authors: Ziehfreund S. , Wecker H. , Mittag S. , Weis J. , Tizek L. , Verkhoturova V. , Legat F. J. , Weger W. , Großschädl K. , Cerpes U. , Sadoghi B. , Riegler M. , Balato A. , Di Brizzi E. V. , Buononato D. , Babino G. , Calzavara‐Pinton P. , Rossi M. T. , Rovaris S. , Dimech A. , Boffa M. J. , Chernyshov P. , Svyatenko T. , Kolodzinska L. , Sikora M. , Torres T. , Manolache L. , Scala E. , Biedermann T. , Zink A. 
Published: August 2024

AbstractBackgroundDermatological research has traditionally concentrated on evaluating mental comorbidities, neglecting positive concepts like happiness. Initial studies indicate that psoriasis and atopic dermatitis (AD) impair the happiness of those affected. Considering global happiness variations, this study aimed to explore the disease‐ and country‐specific differences in disease‐related quality of life and happiness, and potential influential factors on heuristic happiness among psoriasis and AD patients in Europe.MethodsA cross‐sectional multicentre study was conducted in dermatology departments of university‐affiliated hospitals in eight European countries (Austria, Germany, Italy, Malta, Poland, Portugal, Romania and Ukraine) between October 2021 and February 2023. Adult psoriasis and AD patients completed a standardized questionnaire in their native languages, providing data on demographics, disease‐related characteristics, disease‐related quality of life (Dermatology Life Quality Index, DLQI), heuristic happiness, positive affect (PA), negative affect (NA) and satisfaction with life (SWL). Descriptive analysis and quantile regression were performed.ResultsBetween psoriasis (n = 723) and AD (n = 316) patients almost no differences were observed in happiness, SWL and NA, except for DLQI and small differences in PA, with AD patients reporting greater impact than psoriasis patients. Country‐wise variation emerged in DLQI, heuristic happiness, PA, NA and SWL with Austrian patients displaying the highest levels of happiness, satisfaction and positivity, coupled with higher treatment care and lower disease severity. Quantile regression revealed varying coefficients for predictor variables across quantiles, indicating, for example positive effects on heuristic happiness associated with current or previous receipt of systemic therapies at different quantiles.ConclusionsThis study shows notable happiness differences across European countries and significant disease‐related variations, particularly with AD patients being more impaired than psoriasis patients. The findings highlight the need for equality in treatment access and support the development of targeted positive psychological interventions to enhance happiness considering country‐specific distinctions in future research and health policies for psoriasis and AD patients.
Investigation of the relationship between gross motor maturation from 1 to 18 months and preschool gross motor performance in at‐risk infants
Authors: Karanlik Ozge , Acar Gonul , Ayta Semih 
Published: August 2024

AbstractBackgroundAt‐risk infants are predisposed to major and minor neurodevelopmental disorders due to various biological and environmental factors.ObjectiveThis study aimed to investigate the relationship between gross motor maturation from 1 to 18 months and gross motor performance in the preschool period, as well as the risk of developmental coordination disorder (DCD) in at‐risk infants, referred to the Family Counselling Center of the Turkish Spastic Children's Foundation (FCCTSCF) between 2014 and 2016.MethodsFifty‐seven children who had their gross motor maturation assessed between 1 and 18 months at the FCCTSCF were re‐evaluated in the preschool period. The Alberta Infant Motor Scale (AIMS) was used to evaluate gross motor maturation between 1 and 18 months. In contrast, the Gross Motor Function Measure‐88 and the Developmental Coordination Disorder Questionnaire were used to assess gross motor performance in the preschool period.ResultsOf the at‐risk infants included in the study, 45.6% were evaluated as having typical development, 21% were identified as having cerebral palsy (CP), and 33.3% were determined to be at risk for DCD. Children with CP and those at risk for DCD were found to have lower percentile ranks on the past AIMS test compared to the healthy group (p = 0.001). A significant positive correlation was found between the Alberta Infant Motor Scale and the Gross Motor Function Measure‐88 (p = 0.014).ConclusionIn the clinical follow‐up of at‐risk infants, those who scored low on AIMS should be monitored for future risk of DCD and minor disorders, even if major neurological issues such as cerebral palsy are not detected.
Assessing metabolic flexibility response to a multifibre diet: a randomised‐controlled trial
Authors: Aubin Adrien , Hornero‐Ramirez Hugo , Ranaivo Harimalala , Simon Chantal , Van Den Berghe Laurie , Favier Nathalie Feugier , Dussous Isabelle , Roger Loïc , Laville Martine , Béra‐Maillet Christel , Doré Joël , Caussy Cyrielle , Nazare Julie‐Anne 
Published: August 2024

AbstractIntroductionMetabolic flexibility (MetF), defined as the ability to switch between fat and glucose oxidation, is increasingly recognised as a critical marker for assessing responses to dietary interventions. Previously, we showed that the consumption of multifibre bread improved insulin sensitivity and reduced low‐density lipoprotein cholesterol (LDLc) levels in overweight and obese individuals. As a secondary objective, we aimed to explore whether our intervention could also improve MetF.MethodsIn this study, 39 subjects at cardiometabolic risk participated in a double‐blind, randomised, crossover trial lasting 8 weeks, repeated twice. During each phase, participants consumed either 150 g of standard bread daily or bread enriched with a mixture of seven dietary fibres. MetF response was assessed using a mixed‐meal tolerance test (MMTT), analysing changes in respiratory quotient (∆RQ) measured using indirect calorimetry.ResultsAlthough there were no significant differences in ∆RQ changes induced by dietary fibre between the two diets, these changes were positively correlated with postprandial triglyceride excursion (∆TG) at baseline. Subgroup analysis of baseline fasting and postprandial plasma metabolites was conducted to characterise MetF responders. These responders exhibited higher baseline fasting LDLc levels and greater post‐MMTT ∆TG.ConclusionIn conclusion, although dietary fibres did not directly impact MetF in this study, our findings highlight potential determinants of MetF response, warranting further investigation in dedicated future interventions.
Does an early hands‐on breastfeeding intervention by midwives affect nipple pain incidence? An observational pilot study
Authors: Takahashi Yuki , Brimdyr Kajsa , Cadwell Karin 
Published: August 2024

AbstractAimTo describe the timing and characteristics of midwives' hands‐on interruptions of newborns' behavior while in skin‐to‐skin contact during the first hour after birth and to elucidate the relationship between these hands‐on interruptions and the incidence of nipple pain during the first 4 days postpartum.MethodsAn observational pilot study was conducted at a Baby‐Friendly® hospital in Japan from 2016 to 2018. Iterative analysis of video recordings from a larger study of the behavior of newborns while skin‐to‐skin with their mothers in the first hour after birth found 16 full‐term newborns who were born vaginally and that met the inclusion criteria of a midwife's hands‐on intervention (HOI) interrupting the infant's progress toward breast self‐attachment. The timing of the HOI and the stage of the newborn's progress through Widström's 9 Stages was noted by two research assistants who had been blinded to the medical records. The degree of nipple pain after breastfeeding was self‐evaluated by mothers each day during their hospitalization. All data were statistically analyzed.ResultsInterrupting the infant's progressive behaviors in the first hour after birth by midwives' hands‐on “help” to breastfeed, may increase nipple pain during the 4 days after birth. One hundred percent of the mothers reported nipple pain in the postpartum with the highest pain reports occurring on day 4.ConclusionInterrupting skin‐to‐skin contact with HOI does not decrease the incidence of nipple pain during the first days postpartum. HOI for newborn infants was not shown to support breastfeeding in the early postnatal period.
Physical, emotional, and financial burdens of toileting assistance for family caregivers in home care settings and factors associated with each burden: A cross‐sectional study
Authors: Shogenji Miho , Yoshida Mikako , Kakuchi Takahiro , Hirako Kohei 
Published: August 2024

AbstractAimCaregivers in home care settings may experience significant physical, emotional, and financial burdens in providing toileting assistance. However, few studies have evaluated these three aspects of caregiver burden. Therefore, this study aimed to clarify the physical, emotional, and financial burdens of toileting assistance and examine the factors associated with each burden.MethodsA self‐administered postal questionnaire was distributed to 405 family caregivers of older adults receiving home care and subsidies for incontinence products in Japan in 2019. Family caregivers answered questions about toileting assistance, the perceived physical, emotional, and financial burdens of providing toileting assistance at home, and the urinary/fecal symptoms of older adults.ResultsOf the 242 family caregivers who reported each burden, 213 (88%) had experienced at least one physical, emotional, or financial burden. The prevalence of physical, emotional, and financial burdens was 77.3%, 78.1%, and 70.7%, respectively. Approximately 60% of respondents reported experiencing all three burdens. Physical burden was associated with spouses acting as primary caregivers, nocturia, fecal incontinence, and the odor of urine/feces from toileting assistance. Emotional burden was associated with nighttime assistance, urinary/fecal leakage from absorbent incontinence products, and the odor of urine/feces. Financial burden was associated with frequent assistance, disposal costs of absorbent incontinence products, and the degree of toileting assistance.ConclusionsThe results revealed a high prevalence of the three burdens of toileting assistance among family caregivers, suggesting the need to assess these burdens. Furthermore, they suggested the importance of providing guidance to family members, which may help reduce these burdens.
The SOE Premium and Government Support in China's Credit Market
Authors: GENG ZHE , PAN JUN 
Published: August 2024

ABSTRACTStudying China's credit market using a structural default model that integrates credit risk, liquidity, and bailout, we document improved price discovery and a deepening divide between state‐owned enterprises (SOEs) and non‐SOEs. Amidst liquidity deterioration, the presence of government bailout helps alleviate the heightened liquidity‐driven default, making SOE bonds more valuable and widening the SOE premium. Meanwhile, the increased importance of government support makes SOEs more sensitive to bailout, while the heightened default risk increases non‐SOEs' sensitivity to credit quality. Examining the real impact, we find severe performance deteriorations of non‐SOEs relative to SOEs, reversing the long‐standing trend of non‐SOEs outperforming SOEs.
The role of teledentistry in improving oral health outcomes and access to dental care: An umbrella review
Authors: Al‐Buhaisi Diana , Karami Sanaz , Gomaa Noha 
Published: August 2024

AbstractObjectivesThis umbrella review aims to synthesise and summarise the role of teledentistry in improving oral health outcomes and access to dental care.MethodsWe searched the databases PubMed (Medline), Scopus, CINHAL, OVID, ScienceDirect, JSTOR, JBI Database of Systematic Reviews & Implementation Reports and the Cochrane Database of Systematic Reviews through March 2024. Systematic reviews and meta‐analyses on teledentistry were eligible for inclusion. No publication time or language restrictions were applied. Our search retrieved 24 studies for which we conducted quality assessments using the Joanna Biggs Institute (JBI) for Systematic Reviews and Research Synthesis Critical Appraisal Tool. Results were reported according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines.ResultsStudies addressed clinical oral health outcomes, health‐related quality of life and patient experience, access to dental care and cost‐effectiveness of teledentistry compared to conventional, face‐to‐face dental consultations. We found that there was consensus that teledentistry enhanced oral health through the early detection of oral lesions and increased access to dental care in remote areas and was time‐ and cost‐saving.ConclusionTeledentistry can improve oral health outcomes and access to dental care. Future research on its impact on oral health equity is warranted.
What contributes to rising inequality in large cities?
Authors: Ayala Luis , Martín‐Román Javier , Vicente Juan 
Published: August 2024

AbstractThis paper aims to analyze the trends in income inequality in large cities within a selected sample of OECD countries. Specifically, we consider a set of individual characteristics that account for changes in the income distribution and estimate their contribution to differences in inequality in large cities over the last two decades. We use a combination of reweighting techniques and recentered influence functions (RIF) to detect an upward trend in inequality within large cities. This result is mainly driven by changes in the returns to endowments rather than by changes in its distribution. Our findings suggest that these results are not of the same magnitude across the countries analyzed. A key finding is that the contribution to inequality of the skill premium is considerably higher in North American countries than in European countries.
Normative cortical activation patterns in children distinguishing one or two tactile sensory inputs points: An functional MRI study
Authors: Donne Jack H. , Beare Richard , Powell Jennifer A. , Fahey Michael C. , Williams Cylie M. 
Published: August 2024

AbstractThis study aims to determine if children follow the same cortical activation patterns as adults when responding to two‐point discrimination sensory stimuli during functional magnetic resonance imaging (fMRI). We recruited 15 children with typical development, aged between 8 and 16 years. These participants were asked to complete a two‐point discrimination test (task block) while undergoing an fMRI scan. In the two‐point stimulus test, strong activation compared to baseline was observed in the left and right frontal orbital cortex. The inferior parietal lobe also exhibited activity, particularly on the right side, with activation in both the supramarginal and angular gyri. Further activity was evident in the left supramarginal gyrus and the left paracingulate gyrus. This novel study on fMRI two‐point discrimination testing in children shows the activation patterns in key brain regions involved in somatosensory discrimination and decision making.Practical ApplicationsThis study provides crucial normative data on cortical activation patterns during two‐point discrimination testing in typically developing children. Such data serve as a valuable reference point for future research investigating sensory processing and cognitive function in pediatric populations. Researchers can use these findings to establish benchmarks and compare cortical activation patterns in children with neurodevelopmental conditions. This information is essential for exploring pathology, which may affect tactile sensation techniques and developing targeted interventions tailored to individual needs in pediatric treatment. Additionally, it lays the groundwork for further exploration into the neural mechanisms underpinning somatosensory discrimination, potentially leading to advancements in understanding and treating sensory‐related disorders in children.
Parental views on prospective consent: Experience from a pilot randomised trial recruiting extremely preterm infants during the perinatal period
Authors: Skelton Hannah , Goyen Traci‐Anne , Viola Patricia , Marceau James , D'Cruz Daphne , Maheshwari Rajesh , Shah Dharmesh , Edney Bronwyn , Luig Melissa , Jani Pranav R 
Published: August 2024

AimTo explore parental perceptions of the consenting process and understanding of the study in a pilot randomised controlled trial wherein extremely premature infants (<29 weeks' gestation) were recruited either antenatally or by 4 h of life.MethodsWe prospectively surveyed parents who had consented, declined consent or were eligible infants in the Positioning Preterm Infants for Neuroprotection study, a low‐risk intervention study in the first 72 h of life. Structured interview questions explored the process and acceptability of the consenting approach by the parents and their knowledge of the study. Additional comments made by the parents were transcribed verbatim.ResultsSixty‐two parents participated in the surveys; of those, 41 had provided their consent, 8 declined consent and 13 were parents of missed eligible infants. Overall, most parents reported they understood the study well before providing their consent and approaching them for consenting did not create a burden for them. A verbal explanation of the study by the study team, especially by the medical practitioners, was viewed as beneficial. Where consent was obtained in the birthing unit (imminent births and within 4 h of birthing), it was suggested that the 4‐h period for obtaining post‐natal consent may be too short. A deferred consent with a follow‐up opportunity for obtaining informed consent could be a suitable alternative.ConclusionParents found the consenting process acceptable and indicated they had sufficient understanding of the study to provide an informed consent. Deferred consent should be explored for future, low‐risk intervention studies as an alternative to prospective consent where extremely preterm infants need to be recruited in the immediate neonatal period.
Effects of partial or full replacement of soybean meal with urea or coated urea on intake, performance, and plasma urea concentrations in lactating dairy cows
Authors: Rauch Rainer , Nichols Kelly , de Carvalho Isabela P. C. , Daniel Jean‐Baptiste , Martín‐Tereso Javier , Dijkstra Jan 
Published: August 2024

AbstractWe expected mitigation of the hypophagic effects of urea (U) with a coated urea (CU) product that aimed to partially shift urea supply to the post‐ruminal gastrointestinal tract. Ruminal release and post‐ruminal digestibility of CU was evaluated in vitro, followed by a randomised complete block experiment (54 Holstein‐Friesian cows; 177 ± 72 days in milk). Soybean meal (SBM) was partially (PR) or fully (FR) replaced on an isonitrogenous basis by beet pulp and U or CU. Urea sources were included at 12 (U‐PR, CU‐PR) and 19 (U‐FR, CU‐FR) g/kg dietary dry matter (DM). Hypophagic effects were similar for U‐PR and CU‐PR (−11% vs. −7%), and for U‐FR and CU‐FR (−13% vs. −12%) compared with SBM (average 25.8 kg DM intake/d). Compared with SBM, U‐PR and CU‐PR reduced yields of milk (−8%) and protein (−12%), U‐PR reduced yield of fat (−9%) and fat‐ and protein‐corrected‐milk (FPCM; −9%), and CU‐PR tended to reduce FPCM yield (−5%). Compared with SBM, U‐FR and CU‐FR respectively reduced yields of milk (−21%, −22%), protein (−25%, −26%), fat (both −14%), lactose (−20%, −21%), and FPCM (−17%, −19%), and lowered N (−15%, −12%) and feed (−8%, trend, −9%) efficiency. Human‐edible protein efficiency approximately doubled with U‐PR and CU‐PR and approximately tripled with U‐FR and CU‐FR compared with SBM. Milk composition and plasma urea concentration were similar between U and CU, except for a trend for a greater plasma urea concentration with U‐PR compared with CU‐PR. Dry matter intake patterns differed for CU‐PR compared with U‐PR and for CU‐FR compared with U‐FR, suggesting effects of urea release rate or location on feeding behaviour. Overall, replacing SBM with U or CU reduced DM intake and milk production and affected nutrient efficiencies. Coated urea influenced DM intake pattern but did not affect total DM intake or milk production compared with U.
Adult perceptions of mental health access barriers facing youth in rural Washington State: A group concept mapping study
Authors: Graves Janessa M. , Abshire Demetrius A. , Mackelprang Jessica L. , Klein Tracy A. , Gonzalez Carmen , Parrott Kailee , Eti Deborah U. , Ferris Jordan G. , Chacon Christina M. , Beck Ashley D. 
Published: August 2024

AbstractPurposeTo explore adult community members’ perspectives concerning barriers to mental health care that confront rural‐dwelling youth.MethodsGroup concept mapping, a participatory community‐engaged research method, was used. Adult community members brainstormed and sorted statements describing barriers rural youth encounter in accessing mental health services. Point and cluster maps were created to visualize conceptual similarities between statements. Statements were rated according to their commonness and importance (1: low commonness/importance, 5: high commonness/importance).FindingsThirty‐five adults sorted and/or rated 71 barriers facing rural youth in accessing mental health services. Seven conceptual clusters were identified: system‐level barriers, knowledge and communication, youth concerns, parent/guardian concerns, parent/guardian barriers, costs and convenience, and school‐level barriers. Within youth concerns, community members also identified a subcluster focused on stigma. Common and important statements related to limited after‐school programs and community mental health support initiatives.ConclusionsGroup concept mapping methodology provides structure for conceptualizing challenges facing rural youth in accessing mental health services. Policies should be informed by rural community concerns and priorities. After‐school and support programs may align with mental health needs identified by rural communities.