bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ponseti Casting and Achilles Release Versus Classic Casting and Soft Tissue Releases for the Initial Treatment of Arthrogrypotic Clubfeet
Authors: Kowalczyk Bart , Felus Jaroslaw 
Published: April 2015

Background: Wide soft tissue releases (STRs) are considered the classic operative approach to the arthrogrypotic clubfoot, but recently the Ponseti method with Achilles tenotomy has been proposed as the initial treatment for those deformities. Methods: A retrospective comparison of clinical results and treatment course after 5 to 10 years of follow-up (FU) in arthrogrypotic clubfeet treated initially with STRs or the Ponseti method was performed. Mann-Whitney and χ2 tests were used to assess significant differences between variables. Results: Twenty-nine children with 57 arthrogrypotic clubfeet were divided into 2 subgroups: the Ponseti subgroup (9 children, 18 clubfeet, mean FU: 7.3 years), which achieved 14 good and 4 satisfactory final results. The complication rate was 5.5%. Reoperation rate was 1.2 per foot, with 90.9% being STRs and 9.1% wedge osteotomies. The mean total anesthesia and surgery time equaled 116.6 and 77.4 minutes, respectively. The interval between primary and redo surgery was 27.3 months on average. The STR subgroup (20 children, 39 clubfeet, FU: 9.0 years on average) scored 20 good, 8 satisfactory, and 11 unsatisfactory results. Rate of complications was 23%. The mean total anesthesia and surgery times were 161.4 minutes and 102.8 minutes, respectively. The interval between the initial and secondary operations was 62.8 months on average. The revision rate was 1.0 per foot with 32.5% repeated STRs, while 67.5% were talectomies, osteotomies, or salvage procedures. Conclusions: The use of the Ponseti method as the initial treatment in arthrogrypotic clubfeet improved clinical outcomes, reduced invasiveness of revisions, and shortened overall time of anesthesia and surgery. Level of Evidence: Level III, retrospective comparative series
Less Than Total Excision of Infected Prosthetic PTFE Graft Does Not Increase the Risk of Reinfection
Authors: Sgroi Michael D. , Kirkpatrick Vincent E. , Resnick Karen A. , Williams Russell A. , Wilson Samuel E. , Gordon Ian L. 
Published: April 2015

Background: Traditional treatment of infected polytetrafluoroethylene (PTFE) grafts consist of removal of the entire prosthesis. Closure of the native vessels may compromise vascular patency. We examined the outcomes for patients in whom a PTFE remnant of an infected graft was retained on the vessel. Methods: We reviewed the operating room log from 2000 to 2011 and identified all patients who had partial removal of an infected PTFE graft used for hemodialysis or peripheral bypass. These patients were examined for subsequent complications. Results: Twenty-seven patients underwent 30 partial graft excisions with mean follow-up of 27 months. A total of 17% (5 of 30) of the partial graft resection procedures resulted in complications. Of 48 total remnants left behind at the arterial or venous anastomoses, reinfection occurred in 15%. Conclusions: Leaving a well-incorporated small 1-to 5-mm PTFE remnant at the arterial or venous anastomoses can be performed safely with a low risk of complications.
The Influence of Flooring on Environmental Stressors
Authors: Harris Debra D. 
Published: April 2015

Objective: Three flooring materials, terrazzo, rubber, and carpet tile, in patient unit corridors were compared for absorption of sound, comfort, light reflectance, employee perceptions and preferences, and patient satisfaction. Background: Environmental stressors, such as noise and ergonomic factors, effect healthcare workers and patients, contributing to increased fatigue, anxiety and stress, decreased productivity, and patient safety and satisfaction. Methods: A longitudinal comparative cohort study comparing three types of flooring assessed sound levels, healthcare worker responses, and patient Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) ratings over 42 weeks. A linear mixed model analysis was conducted to determine significant differences between the means for participant responses and objective sound meter data during all three phases of the study. Results: A significant difference was found for sound levels between flooring type for equivalent continuous sound levels. Carpet tile performed better for sound attenuation by absorption, reducing sound levels 3.14 dBA. Preferences for flooring materials changed over the course of the study. The HCAHPS ratings aligned with the sound meter data showing that patients perceived the noise levels to be lower with carpet tiles, improving patient satisfaction ratings. Conclusions: Perceptions for healthcare staff and patients were aligned with the sound meter data. Carpet tile provides sound absorption that affects sound levels and influences occupant’s perceptions of environmental factors that contribute to the quality of the indoor environment. Flooring that provides comfort underfoot, easy cleanability, and sound absorption influence healthcare worker job satisfaction and patient satisfaction with their patient experience.
Case Study
Authors: McCurdy John M. , Haliburton James R. , Yadav Hardik C. , Yoder Allison M. , Norton Lindsey R. , Froehlich Josef A. , Kaur Harpreet , Kramer Nicholas F. , Silman Ayesha , Quinn Brian J. , Pudlo Sharon , Terrell Christina Butler , El-Mallakh Rif S. 
Published: April 2015

Objective: The psychiatric emergency room is a dynamic and sometimes volatile environment. Its design may be an important variable in patient care, but most design decisions are based on models of thought and treatment with a minimal evidence base. Background: The concept of open design, increasing access of patients to nursing staff, for inpatient psychiatric units has recently gained widespread acceptance, despite a dearth of empirical data. Methods: We examined rates of seclusion and restraint before and after a design change that reduced the openness of the unit in a dedicated emergency psychiatric service in a general university hospital. Quality assurance data regarding the census, occurrence of assaults, and the use of seclusion and restraint were queried. Two independent analyses utilizing a test of proportional data were performed to replicate the findings. Results: After placement of a door to restrict patients’ access to the waiting area of the unit, the rate of the use of seclusion and restraint went from 0.03 (44/777) to 0.0185 (27/1,514; z = 2.02, p < .04). Replication over a separate time period saw reduction from 0.029 (67/2,277) to 0.018 (44/2,431), z = 2.44, p < .02). Conclusion: A design change that reduced the openness of the unit resulted in the reduction of seclusion and restraint.
RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug
Authors: Wermke Martin , Camgoz Aylin , Paszkowski-Rogacz Maciej , Thieme Sebastian , von Bonin Malte , Dahl Andreas , Platzbecker Uwe , Theis Mirko , Ehninger Gerhard , Brenner Sebastian , Bornhäuser Martin , Buchholz Frank 
Published: April 2015

Key Points
Large-scale loss-of-function RNAi screens in patient-derived AML cells are feasible and able to pinpoint therapeutic targets. ROCK1 inhibition exerts antileukemic effects in primary human AML cells in vitro and in vivo.
Heavy metals determination in honey samples using inductively coupled plasma-optical emission spectrometry
Authors: Aghamirlou Hasan Mohammadi , Khadem Monireh , Rahmani Abdolrasoul , Sadeghian Marzieh , Mahvi Amir Hossein , Akbarzadeh Arash , Nazmara Shahrokh 
Published: April 2015

Abstract

Background
Honey contains a complex mixture of carbohydrates and other minor substances. Elements are minor constituents of honey that may threaten the human health in excess concentrations. So, determining the metals in honey helps its quality control as a food product. The aim of this study was to determine the concentrations of some metals in Iranian honey.

Methods
This study was performed in four regions of Ardabil, a province of Iran. Honey samples (n = 25) were digested in microwave oven by nitric acid and hydrogen peroxide, then analyzed using inductively coupled plasma– optic emission spectrophotometry (ICP-OES).

Results
No significant differences were observed in cadmium, zinc, nickel, and chromium levels between regions (P > 0.05). Zinc was the most abundant metal in honey samples (1481.64 μg/kg). Some metals had higher concentrations in the East region because of existence more industries there. The highest mean of lead level was 935.48 μg/kg in the East and the lowest was 205.4 μg/kg in the South region. The concentrations of metals were compared with recommended limits for foods. Some of them were higher than standard levels (lead) and some were lower than those (cadmium).

Conclusions
Metals are released into the environment through their use in industrial processes and enter the food chain from uptake by plants from contaminated soil or water. Metals concentration in various places depends on many variables, leading to their different concentrations in honey. Some control measures like the quality control of food products, monitoring the soil in agricultural regions and limiting the use of fertilizers are recommended.
Net-authoritarianism? How web ideologies reinforce political hierarchies in the Italian 5 Star Movement
Authors: Treré Emiliano , Barassi Veronica 
Published: April 2015

Abstract
This article responds to current critiques about the myths of digital democracy drawing on the case study of the Italian Movimento 5 Stelle/5 Star Movement (5SM) lead by comedian-turned-politician Beppe Grillo. We argue that the political success of the 5SM was largely dependent on a process of technological fetishism of the Net as an autonomous political agent. We also contend that this process has enabled the party leaders to build an ideology of the movement and represent the 5SM as a grassroots movement based on horizontal networks, participatory democracy, and characterized by the absence of leadership. Conversely, we claim that the digital rhetoric of horizontality, lack of leadership and spontaneity of the party is used to mask, facilitate and reinforce the authority of Beppe Grillo as political leader, thus forging a new type of authoritarianism that is supported and legitimated through the everyday construction of digital discourse.
Setting analytical performance specifications based on outcome studies – is it possible?
Authors: Horvath Andrea Rita , Bossuyt Patrick M.M. , Sandberg Sverre , John Andrew St , Monaghan Phillip J. , Verhagen-Kamerbeek Wilma D.J. , Lennartz Lieselotte , Cobbaert Christa M. , Ebert Christoph , Lord Sarah J. , for the Test Evaluation Working Gro  
Published: April 2015

AbstractThe 1st Strategic Conference of the European Federation of Clinical Chemistry and Laboratory Medicine proposed a simplified hierarchy for setting analytical performance specifications (APS). The top two levels of the 1999 Stockholm hierarchy, i.e., evaluation of the effect of analytical performance on clinical outcomes and clinical decisions have been proposed to be replaced by one outcome-based model. This model can be supported by: (1a) direct outcome studies; and (1b) indirect outcome studies investigating the impact of analytical performance of the test on clinical classifications or decisions and thereby on the probability of patient relevant clinical outcomes.This paper reviews the need for outcome-based specifications, the most relevant types of outcomes to be considered, and the challenges and limitations faced when setting outcome-based APS. The methods of Model 1a and b are discussed and examples are provided for how outcome data can be translated to APS using the linked evidence and simulation or decision analytic techniques.Outcome-based APS should primarily reflect the clinical needs of patients; should be tailored to the purpose, role and significance of the test in a well defined clinical pathway; and should be defined at a level that achieves net health benefit for patients at reasonable costs. Whilst it is acknowledged that direct evaluations are difficult and may not be possible for all measurands, all other forms of setting APS should be weighed against that standard, and regarded as approximations. Better definition of the relationship between the analytical performance of tests and health outcomes can be used to set analytical performance criteria that aim to improve the clinical and cost-effectiveness of laboratory tests.
Does a picture say more than 7000 words? Windows of opportunity to learn languages – an attempt at a creative reflective poster
Authors: Schaller-Schwaner Iris 
Published: April 2015

AbstractThis article originated in a creative attempt to engage audiences visually, on a poster, with ideas about language(s), teaching and learning which have been informing language education at university language centres. It was originally locally grounded and devised to take soundings with colleagues and with participants at the CercleS 2014 Conference hosted at the University of Fribourg. It uses a local campus building as a reflective canvas, as it were. Simultaneously, it deals with concepts of wider currency which may influence and engage language teachers’ awareness and practices in other tertiary contexts. The poster’s visual appeal not only contrasts with the linearity of academic writing but its open-endedness creates a space for exchange and discussion. It also creates a space for theory, which few practitioners will engage with of their own accord. The poster’s inherent dimension of interpretation by the viewer extends an invitation to respond. This article may render its content more tangible or accessible through verbal elaboration that complements the visual. The notions and cognitions discussed include reflection(s), languaging, a language formula, the Indo-European tree of languages, a multilingual linguistic sign, Douglas Adams’s Babel fish, the IPA vowel quadrilateral, a syntactic tree, and a pyramid of learning. Presenting this poster and article to a wider audience can be framed as a novel dialogue and dialectic about conceptualisations that are influential for university language teaching. It is also an unorthodox way of approaching theory didactically and with language teacher cognitions (
Teaching science subjects in Arabic: Arab university scientists’ perspectives
Authors: Alhamami Munassir 
Published: April 2015

AbstractThis study investigates Arab university scientists’ views of the status of English and Arabic in the 21st century, and their attitudes towards using English and Arabic as media of instruction in science faculties in the Arab world. Twenty-seven science instructors at a Saudi University coming from different backgrounds responded to a written survey, and the data were analyzed quantitatively and qualitatively. The findings reveal that the majority of the science instructors preferred to use the students’ mother tongue (Arabic) to teach science, even though the current policy is to use English as the medium of instruction. The results indicate that, from the perspective of Arab scientists, English as medium of instruction in Saudi universities presents academic and social challenges in science education at university undergraduate level.
Towards new cultures of learning: Personal learning environments as a developmental perspective for improving higher education language courses
Authors: Laakkonen Ilona , Taalas Peppi 
Published: April 2015

AbstractThis article provides readers with an understanding of the concept of the personal learning environment (PLE). It suggests that PLEs can be used in two complementary ways: as a developmental lens for integrating ICT and creating new pedagogical practices and digital literacies for academic language learning, and as a context in which learners can practise and develop core skills such as digital literacies, team and knowledge work, and interactional skills – skills that are needed for success in today’s knowledge economy. The article places PLEs within the broader development related to the cultural changes brought on by the proliferation of Web 2.0 technologies – participation, teamwork and co-design – and considers PLEs in relation to digital literacies and 21st-century skills. It then reports on a research-and-development project that makes use of design-based research and creates tools and models for learner-centred technology integration on the basis of a rich set of data and experiments. The article presents theoretical as well as practical insights into implementing PLEs in higher education (HE) language centre teaching and outlines principles for implementation in formal education. It concludes by expressing the need to purposefully balance the structure provided by traditional approaches to learning against ways of organising it with the nearly unlimited resources and participatory aspects afforded by the new media.
Novel Compact Asymmetric Coplanar Strip (ACPS)-Fed Zeroth-Order Resonant Antennas with Bandwidth Enhancement
Authors: Zhu Li , Gao Xiang-jun , Wang Guang-ming , Li Hai-peng 
Published: April 2015

AbstractTwo compact zeroth-order resonant antennas employing short-ended mu-negative transmission line (MNG-TL) are presented. Both antennas are fed by asymmetric coplanar strip (ACPS), so strong miniaturization and simple structure can be achieved. Proposed antenna 1 operates at 2.38–2.47 GHz (fractional bandwidth is 3.7%), with a size of 0.093
Single Air Bubble Breakup Experiments in Stirred Water Tank
Authors: Solsvik Jannike , Jakobsen Hugo A. 
Published: April 2015

AbstractSingle gas bubbles have been injected into an stirred liquid tank and the eventual breakup process of the bubbles was examined through high-speed imaging. Experimental observations of the breakup probability, breakup time, number of daughter bubbles and daughter bubble size distribution have been collected. The occurrence of non-equal-size breakup events dominated over equal-size breakup events. The frequency of binary and multiple breakup events was about equal. The largest uncertainty is associated with the determination of the breakup time because the bubbles take continuously altering deformed shapes already from the point of injection into the tank. The present experimental data do not support the standard model assumption regarding the number of daughter particles. The active breakup zone in the stirred tank was in the large velocity field close to the radial impeller. It is not evident whether the breakup events are due to time average shear or pressures and velocity fluctuations.
Germline PRKACA amplification causes variable phenotypes that may depend on the extent of the genomic defect: molecular mechanisms and clinical presentations
Authors: Lodish Maya B , Yuan Bo , Levy Isaac , Braunstein Glenn D , Lyssikatos Charalampos , Salpea Paraskevi , Szarek Eva , Karageorgiadis Alexander S , Belyavskaya Elena , Raygada Margarita , Faucz Fabio Rueda , Izatt Louise , Brain Caroline , Gardner James , Quezado Martha , Carney J Aidan , Lupski James R , Stratakis Constantine A 
Published: April 2015

ObjectiveWe have recently reported five patients with bilateral adrenocortical hyperplasia (BAH) and Cushing's syndrome (CS) caused by constitutive activation of the catalytic subunit of protein kinase A (PRKACA). By doing new in-depth analysis of their cytogenetic abnormality, we attempted a better genotype–phenotype correlation of theirPRKACAamplification.DesignThis study is a case series.MethodsMolecular cytogenetic, genomic, clinical, and histopathological analyses were performed in five patients with CS.ResultsReinvestigation of the defects of previously described patients by state-of-the-art molecular cytogenetics showed complex genomic rearrangements in the chromosome 19p13.2p13.12 locus, resulting in copy number gains encompassing the entirePRKACAgene; three patients (one sporadic case and two related cases) were observed with gains consistent with duplications, while two sporadic patients were observed with gains consistent with triplications. Although all five patients presented with ACTH-independent CS, the three sporadic patients had micronodular BAH and underwent bilateral adrenalectomy in early childhood, whereas the two related patients, a mother and a son, presented with macronodular BAH as adults. In at least one patient,PRKACAtriplication was associated with a more severe phenotype.ConclusionsConstitutional chromosomalPRKACAgene amplification is a recently identified genetic defect associated with CS, a trait that may be inherited in an autosomal dominant manner or occurde novo. Genomic rearrangements can be complex and can result in different copy number states of dosage-sensitive genes, e.g., duplication and triplication.PRKACAamplification can lead to variable phenotypes clinically and pathologically, both micro- and macro-nodular BAH, the latter of which we speculate may depend on the extent of amplification.
Unusual Skin Metastasis in a Patient with Recurrent Micropapillary Serous Ovarian Carcinoma – A Case Report and Review of the Literature
Authors: Achimaş-Cadariu Patriciu , Vlad Cătălin , Fetica Bogdan , Zgaia Armeana , Cainap Calin 
Published: April 2015

The presence of skin metastasis in ovarian cancer patients is uncommon and related with poor prognosis. We report a 49-year-old patient with recurrent ovarian cancer presented with extensive skin metastasis on the anterior chest (including bilateral breast skin), lower abdomen, vulva and the upper part of the lower limbs at 21 months after initial diagnosis of ovarian cancer. The skin biopsy revealed metastasis of adenocarcinoma in the dermis. The patient underwent palliative chemotherapy and she died after 2 months of the diagnosis of the skin metastasis. It is the first case of skin metastasis from a micropapillary serous ovarian carcinoma published in Romania.
Upper altitudinal and southern geographic range extensions for Cruziohyla craspedopus (Anura: Hylidae) (Funkhouser, 1957) in Ecuador
Authors: Núñez Darwin , Riera-Vite Trotsky , Orellana Flavio , Brito Jorge 
Published: April 2015

We report the southernmost record of Cruziohyla craspedopus in Ecuador. An adult female was collected in the province of Zamora Chinchipe in southern Ecuador in the Cordillera del Condor. This record increases the previously reported altitudinal range for the species by 468 m and extends the distribution by 105 km to the south.