bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geometry as a Factor for Tissue Growth: Towards Shape Optimization of Tissue Engineering Scaffolds
Authors: Bidan Cécile M. , Kommareddy Krishna P. , Rumpler Monika , Kollmannsberger Philip , Fratzl Peter , Dunlop John W. C. 
Published: November 2012

AbstractScaffolds for tissue engineering are usually designed to support cell viability with large adhesion surfaces and high permeability to nutrients and oxygen. Recent experiments support the idea that, in addition to surface roughness, elasticity and chemistry, the macroscopic geometry of the substrate also contributes to control the kinetics of tissue deposition. In this study, a previously proposed model for the behavior of osteoblasts on curved surfaces is used to predict the growth of bone matrix tissue in pores of different shapes. These predictions are compared to in vitro experiments with MC3T3‐E1 pre‐osteoblast cells cultivated in two‐millimeter thick hydroxyapatite plates containing prismatic pores with square‐ or cross‐shaped sections. The amount and shape of the tissue formed in the pores measured by phase contrast microscopy confirms the predictions of the model. In cross‐shaped pores, the initial overall tissue deposition is twice as fast as in square‐shaped pores. These results suggest that the optimization of pore shapes may improve the speed of ingrowth of bone tissue into porous scaffolds.
Polyols production by chemical modification of autocatalyzed ethanol‐water lignin from Betula alnoides
Authors: Xue Bai‐Liang , Wen Jia‐Long , Xu Feng , Sun Run‐Cang 
Published: November 2012

AbstractBetula alnoides lignin, recovered as a byproduct in autocatalyzed ethanol‐water pulping process, was converted into viscous polyether polyols through oxypropylation and liquefaction methods, with the aim of adding value to this byproduct. The oxypropylation reaction was performed by reacting autocatalyzed ethanol‐water lignin (AEL) with propylene oxide under the acidic and alkaline conditions at room temperature, respectively. In contrast, the liquefaction reaction was carried out using the mixed solvents of polyethylene glycol and glycerol at 160°C with sulfuric acid as a catalyst. The resulting polyether polyols from each method was characterized by Fourier transform‐infrared (FTIR), 1H and 31P nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC), and thermogravimetric analysis. Quantitative 31P NMR indicated that all the aliphatic hydroxyl group values of polyols increased significantly by the above two methods. More secondary hydroxyl groups (2.016 mmol/g) were obtained in the alkaline oxypropylation reaction, whereas more primary hydroxyl groups (4.296 mmol/g) were found in the liquefied product. GPC analysis showed that the alkaline oxypropylated product (Mw 3130 g/mol, Mn 2080 g/mol) and liquefied product (Mw 4990 g/mol, Mn 4630 g/mol) have higher molecular weights than AEL (Mw 2560 g/mol, Mn 1530 g/mol). Thermal stability analysis suggested that the polyether polyols have a lower degradation temperature than AEL. These polyols used as precursors in polyurethane synthesis give promising properties, which open new avenues of exploitation of AEL. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Ionic nanocomposite networks in poly(styrene‐co‐methacrylic acid) copolymers with calcium carbonate
Authors: Chevallier Celine , Ni Yiping , Vera Ruben , Becquart Frederic , Taha Mohamed 
Published: November 2012

AbstractTo create reversible supramolecular ionic networks, ionic cross‐links were formed from acid pendant functions in poly(styrene‐co‐methacrylic acid) copolymers by the addition of calcium carbonate. The random dispersion of acid functions in the polystyrene chain is ensured by NMR analysis. The partial reaction of the calcium carbonate with the carboxylic acids is highlighted by a limewater test. The influence of methacrylic acid and calcium‐carbonate contents on the formation of an ionic network has been studied through solubility tests. Two main effects were obtained: the exfoliation of the unreacted calcium carbonate characterized by TEM is due to ionic interactions at the surface of nanometric particles that form the first level of organization of the calcium carbonate. Another part of the calcium carbonate reacts with carboxylic acid and is detached from particles to form clusters as shown by x‐ray analysis. Finally, by analyzing the dynamic rheological spectrum, the conclusion that the strength of the ionic bonds arises with the calcium content is made. The interest of such an approach with a wide range of observed phenomena in the material is a one‐batch process to make thermoreversible nanocomposite networks. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Sensitivity of ephemeral wetland swards with Isoetes histrix Bory to environmental variables: implications for the conservation of Mediterranean temporary ponds
Authors: Bagella Simonetta , Caria Maria Carmela 
Published: November 2012

ABSTRACT

Small‐scale landscape elements such as freshwater ponds and pools remain poorly characterized and vulnerable to destruction, despite their significant contribution to regional aquatic biodiversity.
Ephemeral wetland swards supporting Isoetes histrix, which are considered priority interest habitats by the European Habitats Directive on the conservation of wild fauna and flora (codex 3170* – Mediterranean temporary ponds), typify concave pond shorelines (Habitat A) and very shallow flat temporary ponds (Habitat B).
It is hypothesized that although this sward type is highly specialized for growth in waterlogged soils, it is highly sensitive to changes in composition and seasonal dynamics related to varied environmental conditions. The present study was aimed at comparing plant assemblages, and successional processes and dynamics during the growing season between different habitat types; and identifying the key factors influencing spatial variability.
Vegetation was sampled three times during the growing season in the two habitat types (i.e A and B). At each site a range of environmental variables was also recorded.
PERMANOVA analysis indicated that plant assemblages differed between the two habitat types throughout the growing season. The different hydroperiod length was the main factor responsible for the specificity of the two habitats, revealed by CCA. However, the pattern of successional processes and seasonal dynamics was similar between the two habitats.
The results confirmed the hypothesis, and strengthened the understanding of the relevance of hydroperiod length to plant assemblages in ephemeral ponds.
The two habitats exhibit unique characteristics, and represent different aspects of priority habitat 3170*; therefore, to ensure that the highest level of biodiversity is maintained, measures must be taken to protect both sward habitats.Copyright © 2012 John Wiley & Sons, Ltd.
Imidazopyridine‐Based Inhibitors of Glycogen Synthase Kinase 3: Synthesis and Evaluation of Amide Isostere Replacements of the Carboxamide Scaffold
Authors: Yngve Ulrika , Söderman Peter , Svensson Mats , Rosqvist Susanne , Arvidsson Per I. 
Published: November 2012

AbstractIn this study, we explored the effect of bioisostere replacement in a series of glycogen synthase kinase 3 (GSK3) inhibitors based on the imidazopyridine core. The synthesis and biological evaluation of a number of novel sulfonamide, 1,2,4‐oxadiazole, and thiazole derivates as amide bioisosteres, as well as a computational rationalization of the obtained results are reported.
ChemInform Abstract: Synthesis and Luminescence Properties of the Lithium‐Containing Lanthanum‐Oxycarbonate‐Like Borates.
Authors: Kang Youjun , Liu Chunmeng , Kuang Xiaojun , Mi Jinxiao , Liang Hongbin , Su Qiang 
Published: November 2012

AbstractThe new compound Li0.6La2O2.25(BO3)0.7 and its Eu3+‐doped analog are synthesized by solid state reaction of stoichiometric mixtures of H3BO3, Li2CO3, and Ln2O3 (Ln: La, Eu; 1040—1070 °C, 8 h).
ChemInform Abstract: Structures and Self‐Activating Photoluminescent Properties of Sr3‐xAxGaO4F (A: Ba, Ca) Materials.
Authors: Green Robert , Vogt Thomas 
Published: November 2012

AbstractThe structures and photoluminescence properties of the mixed oxyfluorides of title are compared to Sr3‐xAxAlO4F (A: Ba, Ca) materials.
ChemInform Abstract: Synthesis, Crystal Structure and Characterization of a New Compound, Li3NaBaB6O12.
Authors: Chen Songjie , Pan Shilie , Zhao Wenwu , Yang Zhihua , Wu Hongping , Yang Yun 
Published: November 2012

AbstractMillimeter‐sized single crystals of the title compound are obtained from a melt of Li2CO3, Na2CO3, BaCO3, PbO, and H3BO3 in the molar ratio of 7:5.5:3.5:20 (Pt crucible, 800 °C, 10 h).
ChemInform Abstract: Synthesis of Transition Metal Nitride by Nitridation of Metastable Oxide Precursor.
Authors: Wang Huamin , Wu Zijie , Kong Jing , Wang Zhiqiang , Zhang Minghui 
Published: November 2012

AbstractMetastable amorphous MoO2, obtained by reduction of aqueous (NH4)6Mo7O24 solutions with hydrazine (70 °C, 0.5 h followed by heating under a flow of Ar at 300 °C for 2 h) transforms into face‐centered cubic γ‐Mo2N in flowing NH3 at 400 °C and then into hexagonal δ‐MoN by increasing the temperature to 600 °C.
ChemInform Abstract: Synthesis, Structure and Magnetic Properties of La3Co2SbO9: A Double Perovskite with Competing Antiferromagnetic and Ferromagnetic Interactions.
Authors: Franco D. G. , Fuertes V. C. , Blanco M. C. , Fernandez‐Diaz M. T. , Sanchez R. D. , Carbonio R. E. 
Published: November 2012

AbstractReddish‐black polycrystalline powder of the title compound is prepared by solid state reaction of a stoichiometric mixture of La2O3, Co3O4, and Sb2O3 (950 °C for 12 h and 1400 °C for 12 h).
ChemInform Abstract: Chemoenzymatic Preparation of Optically Active 3‐(1H‐Imidazol‐1‐yl)cyclohexanol‐based Ionic Liquids: Application in Organocatalysis and Toxicity Studies.
Authors: Paul Caroline E. , Gotor‐Fernandez Vicente , Lavandera Ivan , Montejo‐Bernardo Jose , Garcia‐Granda Santiago , Gotor Vicente 
Published: November 2012

AbstractNewly synthesized enantiopure imidazolium salts (VII) are used as chiral phase‐transfer catalysts in the Michael addition of diethyl malonate (IX) to trans‐chalcone (VIII) giving the corresponding adduct (X) albeit with very poor enantioselectivity.
ChemInform Abstract: {1,6}‐Transannular Catalytic Asymmetric Gosteli—Claisen Rearrangement.
Authors: Jaschinski Tobias , Hiersemann Martin 
Published: November 2012

AbstractCyclic 2‐alkoxycarbonyl‐substituted allyl vinyl ethers are transformed into medium‐ and large‐sized carbacycles (8‐ to 14‐membered rings), either in the presence of a chiral Cu(II) catalyst or under uncatalyzed conditions.
ChemInform Abstract: Reductive Etherification of Aldehydes Photocatalyzed by Dicarbonyl Pentamethylcyclopentadienyl Iron Complexes.
Authors: Argouarch Gilles , Grelaud Guillaume , Roisnel Thierry , Humphrey Mark G. , Paul Frederic 
Published: November 2012

AbstractThe reaction of aldehydes with dimethylsilanes under UV light in the presence of piano‐stool complex FEC allows the preparation of various unsymmetrical alkyl ethers.
ChemInform Abstract: [HSO3‐pmim][CH3SO3] as an Efficient Catalyst for Chemoselective Synthesis of 1,1‐Diacetates under Ultrasound Irradiation.
Authors: Li Chao , Guo Tao , Zhou Xin , Wang Chun , Ma Jing‐Jun , Li Jin‐Bin 
Published: November 2012

AbstractThe applied catalyst can be reused several times.
ChemInform Abstract: Palladium‐Catalyzed Carbonylation with Mo(CO)6 for the Synthesis of Benzoylacetonitriles.
Authors: Pyo Ayoung , Park Ahbyeol , Jung Hyun Min , Lee Sunwoo 
Published: November 2012

AbstractThe simple and convenient procedure includes the use of Mo(CO)6 which is favorable compared to the toxic CO.
ChemInform Abstract: S‐Allyl Thiocarbamates from Allylic Alcohols by in situ [3,3]‐Sigmatropic Rearrangement of a Thiocarbonyldiimidazole Adduct.
Authors: Mingat Gaelle , Clayden Jonathan 
Published: November 2012

AbstractThiocarbonylimidazole (II) reacts with allylic alcohols to generate intermediate esters of type (III) which rearrange spontaneously in situ to yield S‐allyl imidazolyl thiol esters (IV).
ChemInform Abstract: Xanthates as Synthetic Equivalents of Oxyacyl Radicals: Access to Lactones under Tin‐Free Conditions.
Authors: Davy Jason A. , Mason Jeremy W. , Moreau Benoit , Wulff Jeremy E. 
Published: November 2012

AbstractIn the presence of BEt3 and air, some strained xanthates react with radical cyclization to afford fused lactones.
ChemInform Abstract: Active Methylene Compounds in a Very Effective Approach to 3‐Substituted Isobenzofuranones Through Tandem Aldol/Lactonization Reactions.
Authors: Di Mola Antonia , Croce Gianluca , More Vijaykumar , De Caprariis Paolo , Filosa Rosanna , Massa Antonio 
Published: November 2012

AbstractA new, economic, and environmentally benign K2CO3 catalyzed, solvent‐free one‐pot tandem aldol—lactonization to prepare the title compounds is reported.
ChemInform Abstract: Structural Modulation of Internal Charge Transfer in Small Molecular Donors for Organic Solar Cells.
Authors: Leliege Antoine , Le Regent Charles‐Henri , Allain Magali , Blanchard Philippe , Roncali Jean 
Published: November 2012

AbstractThe covalent bridging of the cyanovinyl thiophene acceptor group by a phenyl ring allows the modulation of internal charge transfer and LUMO energy level of donor materials based on small donor‐acceptor molecules.
ChemInform Abstract: Stereoselective Synthesis of Densely Functionalized Pyrrolidin‐2‐ones by a Conjugate Addition/Nitro‐Mannich/Lactamization Reaction.
Authors: Anderson James C. , Horsfall Lisa R. , Kalogirou Andreas S. , Mills Matthew R. , Stepney Gregory J. , Tizzard Graham J. 
Published: November 2012

AbstractThe products are useful synthetic synthons which can smoothly be converted into various derivatives.
ChemInform Abstract: Catalytic Conversion of Lactide to Optically Pure Heterocycles.
Authors: Tsunoi Shinji , Takahashi Hiroki , Takano Yugo , Okamura Aritomo , Shibata Ikuya 
Published: November 2012

AbstractVarious oxazole derivatives are synthesized from naturally occurring glycolide (I) and lactides (VI) by tin‐catalyzed cycloaddition to isocyanates (II) or isothiocyanates (IV) under microwave irradiation.
ChemInform Abstract: Synthesis of 1,2,3‐Triazole Substituted Isoxazoles via Copper (I) Catalyzed Cycloaddition.
Authors: Ramana P. Venkata , Reddy A. Ram 
Published: November 2012

AbstractThe triazolyl‐substituted isoxazoles (VIII) are obtained via key intermediates (III) by introduction of a triazole ring on C‐4 of the carboxylic acid group of isoxazole by click reaction.
ChemInform Abstract: Ru(II)‐Catalyzed Amidation of 2‐Arylpyridines with Isocyanates via C—H Activation.
Authors: Muralirajan Krishnamoorthy , Parthasarathy Kanniyappan , Cheng Chien‐Hong 
Published: November 2012

AbstractUnder optimized conditions, the amidation occurs regioselectively at the ortho‐position of the phenyl ring.
ChemInform Abstract: Catalytic Radical Cation Salt Induced Csp3—H Functionalization of Glycine Derivatives: Synthesis of Substituted Quinolines.
Authors: Jia Xiaodong , Peng Fangfang , Qing Chang , Huo Congde , Wang Xicun 
Published: November 2012

AbstractIn the presence of the radical cation and oxygen, the reaction of glycine derivatives of type (I)/(VIII) with styrenes or aromatic alkynes allows a new access to quinolines.
ChemInform Abstract: Formation of Acridones by Ethylene Extrusion in the Reaction of Arynes with β‐Lactams and Dihydroquinolinones.
Authors: Fang Yuesi , Rogness Donald C. , Larock Richard C. , Shi Feng 
Published: November 2012

AbstractThe extrusion of 4‐methyleneheptadiene [cf.
ChemInform Abstract: Diketene‐Based Neat Four‐Component Synthesis of the Dihydropyrimidinones and Dihydropyridine Backbones Using Silica Sulfuric Acid (SSA).
Authors: Rostamnia Sadegh , Lamei Kamran 
Published: November 2012

AbstractCyclocondensation of diketene, aldehydes and alcohols in the presence of either NH4OAc or urea allows the synthesis of the biologically important heterocyclic systems (IV) and (VII).
ChemInform Abstract: Microwave‐Assisted, Montmorillonite K‐10 Catalyzed Three‐Component Synthesis of 2H‐Indazolo[2,1‐b]phthalazine‐triones under Solvent‐Free Conditions.
Authors: Reddy Mudumala Veeranarayana , Reddy Gangireddy Chandra Sekahar , Jeong Yeon Tae 
Published: November 2012

AbstractTitle compounds are efficiently synthesized by the present new three‐component reaction of phthalhydrazide (I), dimethylcyclohexanedione (II) and various aldehydes (III).
ChemInform Abstract: Copper‐Catalyzed Sequential Ullmann N‐Arylation and Aerobic Oxidative C—H Amination: A Convenient Route to Indolo[1,2‐c]quinazoline Derivatives.
Authors: Sang Peng , Xie Yongju , Zou Jianwei , Zhang Yuhong 
Published: November 2012

AbstractBenzimidazoquinazolines such as (V) are also available.
ChemInform Abstract: Chichibabin‐Type Condensation of Cyclic Ketones with 3‐Substituted 1,2,4‐Triazin‐5(4H)‐ones.
Authors: Egorov Ilya N. , Tseitler Tatyana A. , Kovalev Igor S. , Slepukhin Pavel A. , Rusinov Vladimir L. , Chupakhin Oleg N. 
Published: November 2012

AbstractThe title reaction allows formation of various new heterocyclic systems.
ChemInform Abstract: Synthesis of New Di‐, Tetra‐, and Hexahydropyrazolo[3,4‐e][1,4]diazepine Derivatives.
Authors: Bol'but A. V. , Kemskii S. V. , Vovk M. V. 
Published: November 2012

AbstractAn efficient procedure for the synthesis of N‐substituted 5‐aminopyrazole‐4‐carboxamides capable to suffer intramolecular diazepine ring closure is given.
ChemInform Abstract: Regioselective Rh(I)‐Catalyzed Sequential Hydrosilylation Toward the Assembly of Silicon‐Based Peptidomimetic Analogues.
Authors: Min Geanna K. , Skrydstrup Troels 
Published: November 2012

AbstractRh‐catalyzed treatment of enamides of type (I), (VI), and (XIII) with hydrosilanes provides a mild and regioselective approach to a wide range of α‐silylated amides.
ChemInform Abstract: Synthesis of N‐Substituted α,α‐Difluoro‐β‐aminophosphonates by Addition of Diethyl Lithiodifluoromethylphosphonate to Imines.
Authors: Cherkupally Prabhakar , Beier Petr 
Published: November 2012

AbstractThe benzyl and Boc protective groups are readily removed under standard conditions.
ChemInform Abstract: Synthetic Approaches and Pharmacological Activity of 1,3,4‐Oxadiazoles. A Review of the Literature from 2000‐2012
Authors: Soares de Oliveira Cledualdo , Lira Bruno Freitas , Barbosa‐Filho Jose Maria , Lorenzo Jorge Goncalo Fernandez , Filgueiras de Athayde‐Filho Petronio 
Published: November 2012

AbstractReview: 165 refs.
Eu2+ & Mn2+‐Coactivated Ba3Gd(PO4)3 Orange‐Yellow‐Emitting Phosphor with Tunable Color Tone for UV‐Excited White LEDs
Authors: Guo Ning , Lü Wei , Jia Yongchao , Lv Wenzhen , Zhao Qi , You Hongpeng 
Published: November 2012

AbstractA novel orange‐yellow‐emitting Ba3Gd(PO4)3:x Eu2+,y Mn2+ phosphor is prepared by high‐temperature solid‐state reaction. The crystal structure of Ba3Gd(PO4)3:0.005 Eu2+,0.04 Mn2+ is determined by Rietveld refinement analysis on powder X‐ray diffraction data, which shows that the cations are disordered on a single crystallographic site and the oxygen atoms are distributed over two partially occupied sites. The photoluminescence excitation spectra show that the developed phosphor has an efficient broad absorption band ranging from 230 to 420 nm, perfectly matching the characteristic emission of UV‐light emitting diode (LED) chips. The emission spectra show that the obtained phosphors possess tunable color emissions from yellowish‐green through yellow and ultimately to reddish‐orange by simply adjusting the Mn2+ content (y) in Ba3Gd(PO4)3:0.005 Eu2+,y Mn2+ host. The tunable color emissions origin from the change in intensity between the 4f–5d transitions in the Eu2+ ions and the 4T1‐6A1 transitions of the Mn2+ ions through the energy transfer from the Eu2+ to the Mn2+ ions. In addition, the mechanism of the energy transfer between the Eu2+ and Mn2+ ions are also studied in terms of the Inokuti–Hirayama theoretical model. The present results indicate that this novel orange‐yellow‐emitting phosphor can be used as a potential candidate for the application in white LEDs.
Intramolecular Cascade Hydroarylation/Cycloisomerization Strategy for the Synthesis of Polycyclic Aromatic and Heteroaromatic Systems
Authors: Storch Jan , Bernard Martin , Sýkora Jan , Karban Jindřich , Čermák Jan 
Published: November 2012

AbstractA new PtCl2/PtCl4‐catalyzed hydroarylation/cycloisomerization cascade reaction leading to the formation of two aromatic or heteroaromatic rings in one step is reported. The strategy developed is exemplified by the synthesis of the 5,6‐dihydrobenzo[c]phenanthrene and 6H‐naphtho[2,1‐c]chromene skeletons. Attempts to prepare [8]helicene‐like molecules are also discussed.
pH and Temperature Determine Performance of Oxygen Reducing Biocathodes
Authors: Strik David P. B. T. B. , Picot Matthieu , Buisman Cees J. N. , Barrière Frédéric 
Published: November 2012

AbstractIn this paper we investigate the performance of oxygen reducing biocathodes for microbial fuel cells in relation to temperature and pH. Lower pH does likely improve biocatalytic activity and/or proton availability, and results in higher current. Lower temperature does reduce biocatalytic activity and does not reduce possible oxygen mass transfer limitations. The cathode resistance was in the same order of magnitude at pH 5 to 7 which shows that MFC energy recovery can be higher at lower pH. Overall, these results show that oxygen reducing biocathodes are robust at 660 mA per m2 at +0.15 V vs. Ag/AgCl, pH 5 and 31 °C.
Synthesis of Functionalized Glutamine‐ and Asparagine‐Type Peptoids – Scope and Limitations
Authors: Cardenal Carmen , Vollrath Sidonie B. L. , Schepers Ute , Bräse Stefan 
Published: November 2012

AbstractN‐Alkylated glycine oligomers (‘peptoids’) can serve as potent peptidomimetic systems. Installing different functional groups can often be a challenge, and minimizes yields and purities. Here, we describe the synthesis of different amide‐containing submonomers which were obtained as free bases, as well as their incorporation into peptoids. By using the free amines, the coupling results on solid support could be improved, and various functionalized peptoids were prepared. Additionally, an interesting dimerization side reaction leading to cross‐linked peptoids was observed during synthesis.
Laminar Silk Scaffolds for Aligned Tissue Fabrication
Authors: Mandal Biman B. , Gil Eun Seok , Panilaitis Bruce , Kaplan David L. 
Published: November 2012

Abstract3D‐biomaterial scaffolds with aligned architecture are of vital importance in tissue regeneration. A generic method is demonstrated to produce aligned biomaterial scaffolds using the physics of directional ice freezing. Homogeneously aligned 3D silk scaffolds with high porosity and alignment are prepared. The method can be adapted to a wide range of polymers and is devoid of any chemical reactions, thus avoiding potential complications associated with by‐products. Mechanical properties and cellular responses with chondrocytes and bone‐marrow‐derived hMSCs are studied, assessing survival, proliferation, and differentiation. In vivo tests suggest biocompatibility of the matrices for future tissue engineering applications, specifically in areas where high cellular alignment is needed. magnified image