bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics of honokiol after intravenous guttae in beagle dogs assessed using ultra‐performance liquid chromatography–tandem mass spectrometry
Authors: Liang Yi , Cui Gang , Wang Xiaoxue , Zhang Wei , An Quan , Lin Zongtao , Wang Hong , Chen Shizhong 
Published: March 2014

ABSTRACTA simple, rapid and sensitive ultra‐performance liquid chromatography–tandem mass spectrometry method was developed and validated for the determination of honokiol in beagle dog plasma after intravenous guttae. With addition of the internal standard magnolol, plasma samples were precipitated with methanol and separated on a Shim‐pack XR‐ODS II (2.0 × 100 mm, 2.2 µm) with isocratic elution of methanol and water (80:20) solution at a flow rate of 0.2 mL/min. A good separation of honokiol was achieved within 3.5 min. Quantification was performed on a Waters Quattro Premier XE triple quadrupole mass spectrometer with electrospray ionization inlet in the negative multiple reaction monitoring mode. Good linearity was obtained over the concentration range of 5.12–15580 ng/mL (r2 > 0.998). Intra‐ and inter‐day precisions were <13.10%, and accuracy ranged from 89.21 to 99.92%. The lower limit of quantification for honokiol was 5.12 ng/mL, and honokiol was stable under various conditions (three freeze–thaw cycles, short‐term temperature, post‐preparative and long‐term temperature conditions.). This validated method was successfully applied to the pharmacokinetic study of honokiol in dogs by intravenous guttae. Copyright © 2014 John Wiley & Sons, Ltd.
The messy social lives of objects: Inter‐personal borrowing and the ambiguity of possession and ownership
Authors: Jenkins Rebecca , Molesworth Mike , Scullion Richard 
Published: March 2014

ABSTRACTIn this paper, we position inter‐personal borrowing as a form of non‐market mediated access‐based consumption, a distinct form of exchange that is complex and inherently ambiguous, and a form of consumption that is under researched. We argue that the temporary transfer of possession is a defining feature of borrowing, which causes ambiguity to arise out of an object being simultaneously active in more than one network; a good can often be different things to different people at the same time. From our empirical data, we establish two emergent themes or forms of ambiguity inherent in borrowing. First, we consider the ambiguity of relationships with goods and people. We note that borrowing is significant in forming and maintaining relationships, but also that relationships to goods are significant in determining lending and borrowing practices. Second, we consider the ambiguity of ownership and find that borrowers make appropriation attempts, such that borrowed items may be temporarily treated as profane, before being re‐sacralised by the borrower and then re‐incorporated by the lender into their active network of possessions. The unique characteristics of borrowing identified in our study offer an opportunity to better understand the ambiguity, or ‘messiness’, within an object's social life that is not contained within existing work on the biography of goods. Copyright © 2014 John Wiley & Sons, Ltd.
ChemInform Abstract: High Rate Capability of Li3V2(PO4)3/C Composites Prepared via a TPP‐Assisted Carbothermal Method and Its Application in Li3V2 (PO4)3||Li4Ti5O12.
Authors: Mao Wen‐feng , Zhang Nuo‐nuo , Tang Zhi‐yuan , Feng Ya‐qing , Ma Chen‐xiang 
Published: March 2014

AbstractThe title composite is prepared from mixtures of V2O5, Li2CO3, NH4H2PO4, and meso‐tetraphenyl porphyrin as the carbon source (350 °C for 4 h followed by sintering at 800 °C for 8 h in N2 atmosphere).
ChemInform Abstract: Solution Synthesis and Reactivity of Colloidal Fe2GeS4: A Potential Candidate for Earth Abundant, Nanostructured Photovoltaics.
Authors: Fredrick Sarah J. , Prieto Amy L. 
Published: March 2014

AbstractColloidal nanostructures of Fe2GeS4 are synthesized by injection of a solution of hexamethyldisilazane and hexamethyldisilathiane in octadecene at 120 °C into a mixture of FeCl2, GeI4, hexadecylamine, and octadecene followed by heating (320 °C, 24 h).
ChemInform Abstract: Catalytic, Enantioselective 1,3‐Dipolar Cycloadditions of Nitrile Imines with Methyleneindolinones.
Authors: Gerten Anthony L. , Slade Michael C. , Pugh Kelsie M. , Stanley Levi M. 
Published: March 2014

AbstractThe title reaction in the presence of a catalyst generated in situ from Mg(NT2)2 and an aminoindanol‐derived chiral bisoxaline ligand affords spiro compounds (III) and (VI) in good yields and high enantioselectivities.
ChemInform Abstract: Expanding Dynamic Kinetic Protocols: Transaminase‐Catalyzed Synthesis of α‐Substituted β‐Amino Ester Derivatives.
Authors: Cuetos Anibal , Lavandera Ivan , Goto Vicente 
Published: March 2014

AbstractSeveral enantiopure α‐alkylated β‐amino esters (II)/(III) are obtained via dynamic kinetic resolution employing a kit of transaminases as biocatalysts and isopropylamine as amino donor.
ChemInform Abstract: N‐Alkylation of Amines with Alcohol over Nanosized Zeolite Beta.
Authors: Reddy Marri Mahender , Kumar Macharla Arun , Swamy Peraka , Naresh Mameda , Srujana Kodumuri , Satyanarayana Lanka , Venugopal Akula , Narender Nama 
Published: March 2014

AbstractThe zeolite‐catalyzed reaction of a series of amines with alcohols leads to N‐alkylated amines in most cases.
ChemInform Abstract: Ni‐Catalyzed Reductive Homocoupling of Unactivated Alkyl Bromides at Room Temperature and Its Synthetic Application.
Authors: Peng Yu , Luo Long , Yan Chang‐Song , Zhang Jian‐Jian , Wang Ya‐Wen 
Published: March 2014

AbstractApplication of this method is demonstrated by the total syntheses of racemic Chimonanthine and Folicanthine.
ChemInform Abstract: Stereoselective Addition of Aliphatic Thiols to Internal Alkynes in a Catalytic System with Palladium “Nanosalt” as an Active Site.
Authors: Orlov N. V. , Chistyakov I. V. , Starikova Z. A. , Ananikov V. P. , Beletskaya I. P. 
Published: March 2014

AbstractTitle reaction is achieved using γ‐terpinene as free radical trap and affords vinyl sulfides of E‐configuration.
ChemInform Abstract: Enantioselective Organocatalytic Iodination‐Initiated Wagner—Meerwein Rearrangement.
Authors: Romanov‐Michailidis Fedor , Guenee Laure , Alexakis Alexandre 
Published: March 2014

AbstractA high‐yielding enantioselective semipinacol transposition, initiated by an electrophilic iodination event is described.
ChemInform Abstract: Zn(II) Chloride‐Catalyzed Direct Coupling of Various Alkynes with Acetals: Facile and Inexpensive Access to Functionalized Propargyl Ethers.
Authors: Suzuki Itaru , Yasuda Makoto , Baba Akio 
Published: March 2014

AbstractVarious propargyl ethers are synthesized using in situ generated Zn(OMe)Cl or Zn(OEt)Cl, resp., as catalyst.
ChemInform Abstract: Pd(II)‐Catalyzed Direct C—H Acylation of N‐Boc Hydrazones with Aldehydes: One‐Pot Synthesis of 1,2‐Diacylbenzenes.
Authors: Sharma Satyasheel , Kim Aejin , Park Jihye , Kim Mirim , Kwak Jong Hwan , Jung Young Hoon , Park Jung Su , Kim In Su 
Published: March 2014

AbstractA hydrazone‐directed Pd‐catalyzed ortho‐acylation of acetophenone N‐Boc hydrazones with aromatic aldehydes (II) is developed.
ChemInform Abstract: anti‐Friedel—Crafts‐Type Substitution to Form Biaryl Linkages.
Authors: Gulyas‐Fekete Gergely , Boluda Carlos J. , Westermann Bernhard , Wessjohann Ludger A. 
Published: March 2014

AbstractThe ipso‐substitution of one or two hydroxy groups of phloroglucinol (I) with arene nucleophiles (II) is achieved under Friedel—Crafts‐type conditions to afford dihydroxybiphenyls (III) or monohydroxytriphenyls, such as (IV).
ChemInform Abstract: Single‐Electron‐Transfer (SET)‐Induced Oxidative Biaryl Coupling by Polyalkoxybenzene‐Derived Diaryliodonium(III) Salts.
Authors: Yamaoka Nobutaka , Sumida Kohei , Itani Itsuki , Kubo Hiroko , Ohnishi Yusuke , Sekiguchi Sho , Dohi Toshifumi , Kita Yasuyuki 
Published: March 2014

AbstractThe title reaction proceeds without a metal catalyst by a unique mechanism involving SET oxidation by means of aryliodonium salts followed by electron‐rich aryl transfer.
ChemInform Abstract: Facile Installation of a Hydroxyalkyl Group into Hydroxyanthraquinones and Aminoanthraquinones Through the Modified Marschalk Reaction.
Authors: Zhao Li‐Ming , Ma Feng‐Yan , Jin Hai‐Shan , Ma Jiao , Wang Huan , Fu Chuan‐Zhao 
Published: March 2014

AbstractA simple, mild, and efficient method for the preparation of the target compounds is presented.
ChemInform Abstract: Stereoselective Synthesis of Spirocyclic Oxindoles Based on a One‐Pot Ullmann Coupling/Claisen Rearrangement and Its Application to the Synthesis of a Hexahydropyrrolo[2,3‐b]indole Alkaloid.
Authors: Miyamoto Hiroshi , Hirano Tomohiro , Okawa Yoichiro , Nakazaki Atsuo , Kobayashi Susumu 
Published: March 2014

AbstractA convenient and efficient method for the preparation of spirocyclic oxindoles in good yields with excellent diastereoselectivities is reported.
ChemInform Abstract: Aqueous Morita—Baylis—Hillman Reaction of Unprotected Isatins with Cyclic Enones.
Authors: Gomes Juliana , Sirvent Jordi , Moyano Albert , Rodrigues Manoel T. Jr. , Coelho Fernando 
Published: March 2014

AbstractReadily available 6,7‐dihydro‐5H‐pyrrolo[1,2‐a]imidazol‐7‐ol is used as an unique catalyst for the aqueous Morita—Baylis—Hillman (MBH) reaction between unprotected isatins and cyclic enones.
ChemInform Abstract: An Expedient Synthesis of Pyrrolidinyl Spirooxindole Grafted 3‐Nitrochromanes Through 1,3‐Dipolar Cycloaddition Reaction of Azomethine Ylides
Authors: Rao J. Naga Siva , Raghunathan R. 
Published: March 2014

Abstractazomethine ylides are generated in situ from isatin and amino acids (III) and (V)
ChemInform Abstract: Effective Synthesis of Cyclic Carbonates from Carbon Dioxide and Epoxides by Phosphonium Iodides as Catalysts in Alcoholic Solvents.
Authors: Aoyagi Naoto , Furusho Yoshio , Endo Takeshi 
Published: March 2014

AbstractThe optimized reaction conditions allow the synthesis of five‐membered cyclic carbonates in high yields under mild reaction conditions.
ChemInform Abstract: An Abnormal N‐Heterocyclic Carbene—Copper(I) Complex in Click Chemistry.
Authors: Sau Samaresh Chandra , Roy Sudipta Raha , Sen Tamal K. , Mullangi Dinesh , Mandal Swadhin K. 
Published: March 2014

AbstractA newly developed copper(I) chloro complex is used as an unusual N‐heterocyclic carbene salt to efficiently catalyze Huisgen 1,3‐dipolar cycloaddition reactions of azides with alkynes to give 1,4‐substituted triazoles in excellent yields within short reaction times under solvent‐free conditions.
ChemInform Abstract: From Aspartic Acid to Dihydropyridone‐2‐carboxylates: Access to Enantiopure 6‐Substituted 4‐Oxo‐ and 4‐Hydroxypipecolic Acid Derivatives.
Authors: Vu Huy‐Dinh , Renault Jacques , Toupet Loic , Uriac Philippe , Gouault Nicolas 
Published: March 2014

AbstractThe synthesis of the title compounds employs a gold‐catalyzed enantioselective cyclization.
ChemInform Abstract: Spontaneous Formation of Nitrarine and Polycyclic Skeletons Related to Nitraria Indolic Alkaloids under Non‐enzymic Conditions.
Authors: Gravel Edmond , Harfouche Abha , Salame Rim , Leblanc Karine , Maciuk Alexandre , Poupon Erwan 
Published: March 2014

AbstractNext to the formation of compound (IV) and several byproducts, traces of Nitrarine could be detected after very long reaction times.
ChemInform Abstract: Palladium‐Catalyzed Tandem N—H/C—H Arylation: Regioselective Synthesis of N‐Heterocycle‐Fused Phenanthridines as Versatile Blue‐Emitting Luminophores.
Authors: Yan Lipeng , Zhao Dongbing , Lan Jingbo , Cheng Yangyang , Guo Qiang , Li Xiaoyu , Wu Ningjie , You Jingsong 
Published: March 2014

AbstractA variety of fluorescent molecules comprising imidazole‐fused, benzimidazole‐fused, indole‐fused, and pyrrole‐fused phenanthridines are obtained by this approach.
ChemInform Abstract: Unexpected Copper‐Catalyzed Cascade Synthesis of Quinazoline Derivatives.
Authors: Chen Zhongyan , Chen Jiuxi , Liu Miaochang , Ding Jinchang , Gao Wenxia , Huang Xiaobo , Wu Huayue 
Published: March 2014

AbstractThe title reaction represents a new strategy for the construction of 2‐substituted quinazolines.
ChemInform Abstract: Privileged Substructure‐Based Diversity‐Oriented Synthesis Pathway for Diverse Pyrimidine‐Embedded Polyheterocycles.
Authors: Kim Heejun , Tung Truong Thanh , Park Seung Bum 
Published: March 2014

AbstractA new diversity‐oriented synthesis pathway for the fabrication of a pyrimidine‐embedded polyheterocycles library is developed for potential interactions with diverse biopolymers.
ChemInform Abstract: Regioselective Functionalization of Purine Derivatives at Positions 8 and 6 Using Hindered TMP‐Amide Bases of Zn and Mg.
Authors: Crestey Francois , Zimdars Silvia , Knochel Paul 
Published: March 2014

AbstractA range of purine derivatives are metallated at positions 8 and 6 using TMP‐amide bases.
ChemInform Abstract: Masked Mercapto Acid‐Driven MCR in Task‐Specific Ionic Liquid: A New Stereocontrolled Entry into Bicyclic 1,3‐Thiazines.
Authors: Rai Vijai K. , Rai Prashant Kumar , Thakur Yogita 
Published: March 2014

AbstractAn unprecedented one‐pot four‐component reaction including Michael addition followed by mercaptoacetylative ring transformation allows the synthesis of optically active bicyclic 1,3‐thiazines.
ChemInform Abstract: Jahnellamides, α‐Keto‐β‐methionine‐Containing Peptides from the Terrestrial Myxobacterium Jahnella sp.: Structure and Biosynthesis.
Authors: Plaza Alberto , Viehrig Konrad , Garcia Ronald , Mueller Rolf 
Published: March 2014

AbstractTwo new cyclic peptides, named jahnellamides A and B are isolated from the title myxobacterium.
ChemInform Abstract: Cephalosporolide B Serving as a Versatile Synthetic Precursor: Asymmetric Biomimetic Total Syntheses of Cephalosporolides C, E, F, G, and (4‐OMe‐)G.
Authors: Song Liyan , Liu Yuan , Tong Rongbiao 
Published: March 2014

AbstractCephalosporolide B (I) is efficiently synthesized and exploited for the first time as a versatile biomimetic synthetic precursor for the chemical syntheses of not only cephalosporolides C (II) and G (V) via a challenging diastereoselective oxa‐Michael addition but also the structurally unprecedented cephalosporolides E (III) and F (IV) via a novel biomimetic ring‐contraction rearrangement.
ChemInform Abstract: Advances in Carbon‐Incorporated Non‐noble Transition Metal Catalysts for Oxygen Reduction Reaction in Polymer Electrolyte Fuel Cells
Authors: Hung Tai‐Feng , Chen Syuan‐Hong , Tu Meng‐Hsiu , Lu Zhi‐Hsiang , Chen Chih Kai , Liu Ru‐Shi , Greer Heather F. , Zhou Wuzong , Lo Man‐Yin 
Published: March 2014

AbstractReview: 56 refs.
Assessing survivability of smart grid distribution network designs accounting for multiple failures
Authors: Menasché Daniel Sadoc , Avritzer Alberto , Suresh Sindhu , Leão Rosa M. , de Souza e Silva Edmundo , Diniz Morganna , Trivedi Kishor , Happe Lucia , Koziolek Anne 
Published: March 2014

SUMMARYSmart grids are fostering a paradigm shift in the realm of power distribution systems. Whereas traditionally different components of the power distribution system have been provided and analyzed by different teams through different lenses, smart grids require a unified and holistic approach that takes into consideration the interplay of communication reliability, energy backup, distribution automation topology, energy storage, and intelligent features such as automated fault detection, isolation, and restoration (FDIR) and demand response. In this paper, we present an analytical model and metrics for the survivability assessment of the distribution power grid network. The proposed metrics extend the system average interruption duration index, accounting for the fact that after a failure, the energy demand and supply will vary over time during a multi‐step recovery process. The analytical model used to compute the proposed metrics is built on top of three design principles: state space factorization, state aggregation, and initial state conditioning. Using these principles, we reduce a Markov chain model with large state space cardinality to a set of much simpler models that are amenable to analytical treatment and efficient numerical solution. In case demand response is not integrated with FDIR, we provide closed form solutions to the metrics of interest, such as the mean time to repair a given set of sections. Under specific independence assumptions, we show how the proposed methodology can be adapted to account for multiple failures. We have evaluated the presented model using data from a real power distribution grid, and we have found that survivability of distribution power grids can be improved by the integration of the demand response feature with automated FDIR approaches. Our empirical results indicate the importance of quantifying survivability to support investment decisions at different parts of the power grid distribution network. Copyright © 2014 John Wiley & Sons, Ltd.
Thermal‐aware code transformation across functional units
Authors: Chen Chia Jung , Chang Rong Guey 
Published: March 2014

SummaryVarious functional units (FUs) have been designed in modern embedded processors to perform different functions when running an application. Traditionally, compilers did not take this characteristic into account to reduce the temperature of a processor during execution. For many applications, the occurrences of different instructions are not the same after they are compiled. As a consequence, the temperature of the processor is very high, arising from the major heating contribution of the special structure of the active functional unit, and thus, the system will suffer severe damage. Consequently, to remedy this hurdle, this paper provides a solution by shifting the loading from heavy‐loading FUs to light‐loading FUs. Our approach first identifies all the FUs that can exchange the loading among themselves and then presents a thermal model for these exchangeable FUs to estimate the temperature impact on shifting loading. Finally, the loading shifting has been performed by transforming code under the consideration of limited performance loss without hardware cost. The result shows that our approach can reduce the temperature to a small cost of performance degradation and code expansion. Copyright © 2014 John Wiley & Sons, Ltd.
CyberGIS Gateway for enabling data‐rich geospatial research and education
Authors: Liu Yan , Padmanabhan Anand , Wang Shaowen 
Published: March 2014

SummaryThis paper describes CyberGIS Gateway as an online problem‐solving environment for multiple science communities to conduct data‐rich geospatial research and education. CyberGIS Gateway is a key modality in the CyberGIS software environment. Scalable gateway application integration has been the focus of CyberGIS Gateway in order to efficiently develop highly interactive online geographic information systems (GIS) user interface components and couple a rich collection of heterogeneous and distributed geospatial data and analytical services for advanced cyberGIS capabilities on advanced cyberinfrastructure. An open mashup and service API approach is developed to address the integration challenges in CyberGIS Gateway application development. This approach is applied and evaluated in developing several representative cyberGIS data and analytical applications. The experience gained from the integration practice is shared. The education and outreach activities in CyberGIS Gateway are presented to illustrate the impact of CyberGIS Gateway in GIScience communities and the effective collaboration within the science gateway community. Copyright © 2014 John Wiley & Sons, Ltd.
Performance‐driven dynamic service selection
Authors: Ghezzi Carlo , Panzica La Manna Valerio , Motta Alfredo , Tamburrelli Giordano 
Published: March 2014

SummaryModern software systems are increasingly built by integrating different services implemented by independent organizations and offered in an open service marketplace. In such environment, multiple providers may compete with each other by publishing services that provide the same functionality, and export the same interface, but differ in the offered QoS and in particular in the offered performance. Clients and service integrators may therefore dynamically select the most efficient services that satisfy their requirements among the competing alternatives. Service selection may be performed by clients by following different strategies, which may ultimately affect the overall quality of service invocations. In this paper, we address the problem of analyzing and comparing different service selection strategies based on a framework that supports performance estimates. We report on quantitative analyses through simulations, highlighting advantages and limitations of each strategy. Copyright © 2014 John Wiley & Sons, Ltd.
Design Strategies for Enhanced Hydrogen‐Bond Donor Catalysts
Authors: Auvil Tyler J. , Schafer Andrew G. , Mattson Anita E. 
Published: March 2014

AbstractDual hydrogen‐bond donor (HBD) scaffolds can be strategically designed to enable their optimal performance as catalysts. The deliberate installation of activating groups on HBDs containing conventional functionalities, such as ureas and thioureas, has emerged as one fruitful direction in the identification of catalysts with enhanced activity and improved stereocontrol. Alternatively, new families of HBDs based on structurally unique, inherently more acidic functional groups, such as squaramide and aminopyridinium systems, have proven advantageous over conventional HBD catalysts in select processes. The appropriate incorporation of activating design elements into HBD catalyst frameworks is currently determined empirically and dictated by the specific process under development; each individual reaction benefits from tuning of the HBD catalyst acidity, steric environment, and/or electronic environment. This review presents recent design elements integrated into dual HBD catalyst scaffolds and their influence on HBD catalyst performance.
A High Yield Procedure for the Preparation of 2‐Hydroxynitrostyrenes: Synthesis of Imines and Tetracyclic 1,3‐Benzoxazines
Authors: Tena Pérez Víctor , Fuentes de Arriba Ángel L. , Monleón Laura M. , Simón Luis , Rubio Omayra H. , Sanz Francisca , Morán Joaquín R. 
Published: March 2014

AbstractAttempts to synthesize 2‐hydroxynitrostyrenes by a Knoevenagel condensation of salicylaldehyde and subsequent elimination were unsuccessful because of the formation of a stable imine. This could be easily prevented by using secondary amines to catalyze the reaction, which then afforded 2‐hydroxynitrostyrenes in high yields. In addition, the stable imine that was formed by employing ammonium acetate underwent a reaction with phosgene to allow the preparation of benzoxazines in good yields.