bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of pulmonary toxicity of MgO nanoparticles in rats
Authors: Gelli Kiranmai , Porika Mahendar , Anreddy Rama Narsimha Reddy 
Published: October 2013

ABSTRACTIn this study, we have evaluated the pulmonary toxicity of MgO nanoparticles (MgO NPs) in rats following their exposure. NPs in phosphate buffered saline + 1% Tween 80 were exposed via intratracheal instillation at a doses of 1 mg/kg or 5 mg/kg into rat lungs and evaluated for various tissue damage markers like alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid and histopathology of lungs at 1, 7, and 30 days of post‐exposure intervals. A dose‐dependant increase in ALP and LDH activity was observed in BAL fluids of rat lungs than sham control at all post‐exposure periods (P <0.05), and a dose‐dependant infiltration of interstitial lymphocytes, peribronchiolar lymphocytic infiltration, and dilated and/or congested vessels at 1 day post‐exposure period, worsened at 1 week period, and were reduced at 1 month at histology, indicating the pulmonary toxicity of MgO NPs. In conclusion, MgO NPs exposure produced a dose‐dependent pulmonary toxicity in rats and was comparable with that of Quartz particles. © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 308–314, 2015.
Oncologic Outcomes of Thoracoscopic Esophagectomy with Extended Lymph Node Dissection: 10‐year Experience from a Single Center
Authors: Ninomiya Itasu , Okamoto Kouichi , Fujimura Takashi , Fushida Sachio , Osugi Harushi , Ohta Tetsuo 
Published: October 2013

AbstractBackgroundThe oncologic feasibility of video‐assisted thoracoscopic (VATS) radical esophagectomy for esophageal cancer has yet to be proven. We evaluated the oncologic outcome of VATS‐esophagectomy by reviewing our 10‐year experience, with particular emphasis on the effect of lymph node dissection.MethodsFrom January 2003 to December 2012, 146 patients with esophageal cancer underwent completion of VATS‐esophagectomy in the left lateral position.ResultsThe mean follow‐up period was 37.1 months. Forty‐six patients (31.5 %) had recurrence of cancer. Primary recurrence was hematogenous, lymphatic, peritoneal dissemination, pleural dissemination, locoregional, or port site in 20 (13.7 %), 23 (15.8 %), 2 (1.4 %), 5 (3.4 %), 4 (2.7 %), and 1 (0.67 %) patients, respectively. Pleural dissemination occurred more frequently after noncurative operation than curative operation (p = 0.010). The frequency of lymphatic metastasis within the mediastinal regional lymph nodes in the dissection field was only 5.5 %. The overall 5‐year survival rate of stage I, II, and III disease after curative VATS‐esophagectomy was 79.1, 77.9, and 56.7 %, respectively. T4 tumor, lymph node metastasis, R1 or 2, and concomitant lymph node metastasis in the cervical, mediastinal, and abdominal fields were indicators of unfavorable outcome. The lymph nodes in the abdominal region and those around the bilateral recurrent laryngeal nerves (RLNs) were frequent metastasis sites. Patients who had metastasis only around RLNs had favorable survival comparable to node‐negative cases after curative VATS‐esophagectomy.ConclusionsVideo‐assisted thorascopic‐esophagectomy has an excellent locoregional control effect with favorable oncologic outcome. The lymph node dissection procedure by VATS‐esophagectomy has survival benefit for the patients having lymph node metastasis around bilateral RLNs.
Optimization of Ethanol‐Ultrasound‐Assisted Destabilization of a Cream Recovered from Enzymatic Extraction of Soybean Oil
Authors: Li Yang , Sui Xiaonan , Qi Baokun , Zhang Yan , Feng Hongxia , Zhang Yana , Jiang Lianzhou , Wang Tong 
Published: October 2013

AbstractA novel method using ethanol and ultrasound to extract oil from cream obtained from enzyme‐assisted aqueous extraction of soybean oil was developed. To evaluate the relationships between operating variables and free oil yield and to maximize the free oil yield, response surface methodology was introduced in this work. The developed regression model was fitted with R2 = 0.9591. Optimized variables were: ethanol concentration of 73 %, ethanol addition volume of 0.55 L/kg, ultrasound power of 427 W, ultrasound time of 47 s, and ultrasound temperature of 53 °C. The free oil yield from the cream under the above conditions was 92.6 ± 3.4 %. Scanning electron microscopy (SEM) was used to evaluate the effect of ultrasonic treatment on ethanol‐treated cream, and the SEM images clearly showed that the ultrasound treatment affected dispersing and fracturing of the microstructure of ethanol‐treated cream.
Induced membrane technique for the treatment of congenital pseudarthrosis of the tibia: Preliminary results of five cases
Authors: Pannier Stéphanie , Pejin Zagorka , Dana Caroline , Masquelet Alain Charles , Glorion Christophe 
Published: October 2013

Purpose The purpose of this study was to evaluate the two-stage surgical technique combining induced membrane, spongy autograft and intramedullary fixation for the treatment of congenital pseudarthrosis of the tibia (CPT). Methods Three boys and two girls were treated by this technique between 2003 and 2008. All patients had type IV CPT in Crawford's classification. Four of them had a limited dystrophic form, whereas one case presented an extensive tibia bone dystrophy. The average age of patients at the time of surgery was 23 months (range 10–30 months), with an average follow-up of 5.8 years (range 2.4–8.1 years). Results Satisfactory tibial bony union was achieved in all cases at the last follow-up. Bone healing was obtained in the four limited forms after an average term of 4 months. One patient suffered from a non-displaced fracture that healed by casting in a usual period of time. The patient with an extensive dystrophic bone had to undergo a secondary inter-tibiofibular bone graft to finally achieve bone union. Conclusions The preliminary results show that this technique is successful in CPT. It may be used even in young children and offers a good alternative to other treatments available, avoiding external fixation and the technical difficulties of microvascular surgery.
Non-invasive measurement of the pressure distribution in a deformable micro-channel
Authors: Ozsun Ozgur , Yakhot Victor , Ekinci Kamil L. 
Published: October 2013

AbstractDirect and non-invasive measurement of the pressure distribution in test sections of a micro-channel is a challenging, if not an impossible, task. Here, we present an analytical method for extracting the pressure distribution in a deformable micro-channel under flow. Our method is based on a measurement of the channel deflection profile as a function of applied hydrostatic pressure; this initial measurement generates ‘constitutive curves’ for the deformable channel. The deflection profile under flow is then matched to the constitutive curves, providing the hydrodynamic pressure distribution. The method is validated by measurements on planar microfluidic channels against analytic and numerical models. The accuracy here is independent of the nature of the wall deformations and is not degraded even in the limit of large deflections,${\zeta }_{max} / 2{h}_{0} = O(1)$, with${\zeta }_{max} $and$2{h}_{0} $being the maximum deflection and the unperturbed height of the channel, respectively. We discuss possible applications of the method in characterizing micro-flows, including those in biological systems.
JACOBSON RADICAL ALGEBRAS WITH QUADRATIC GROWTH
Authors: SMOKTUNOWICZ AGATA , YOUNG ALEXANDER A. 
Published: October 2013

AbstractWe show that over every countable algebraically closed field $\mathbb{K}$ there exists a finitely generated $\mathbb{K}$-algebra that is Jacobson radical, infinite-dimensional, generated by two elements, graded and has quadratic growth. We also propose a way of constructing examples of algebras with quadratic growth that satisfy special types of relations.
The Italian Canzone and the Sanremo Festival: change and continuity in Italian mainstream pop of the 1960s
Authors: AGOSTINI ROBERTO 
Published: October 2013

AbstractIn this essay I propose an analysis of the Sanremo Italian Song Festival from 1964 to 1967, to which is added an introduction about its history and musical, social and cultural features. The aim of the essay is not only to propose a different perspective on the songs presented at the Festival in the 1960s, but also to re-configure our understanding of the popular music mainstream and the mechanisms of musical change in our mass-mediated and industrialised societies, as well as the question of identifying the peculiarities of the Italian canzone.
Katrina Seven Years On: The Politics of Race and Recovery— Notes on a Roundtable Organized for the 2012 APSA Annual Meeting
Authors: Day Christine L. 
Published: October 2013

AbstractAfter Hurricane Katrina struck the Gulf Coast in 2005, flooding the city of New Orleans for several weeks after levees collapsed, the city struggled to recover and rebuild. Scholars and activists participating in the roundtable, “Katrina Seven Years On: The Politics of Race and Recovery,” at the 2012 APSA Annual Meeting in New Orleans, were to discuss recovery and racial justice in post-Katrina urban planning and rebuilding efforts, grassroots movements, job recovery, fair housing, and cultural revival. Although the 2012 meeting was canceled as Hurricane Isaac threatened New Orleans anew, panelists offered their observations and ideas to be summarized forPSreaders.
Book Citations Count
Authors: Samuels David 
Published: October 2013

AbstractThis article quantifies books' impact in terms of citation counts—in published articles and in other published books. The average political science book published by a university press receives about three times the number of citations received by an article indexed in the SSCI. Books' impact varies by subfield, with books published in methodology receiving many more citations on average than books published in other subfields, followed by books in international relations. Overall, books published on American politics are cited least frequently. Results suggest that political scientists should supplement quantitative indicators of article and journal impact (which are based only on citations in peer-reviewed articles) with similar measures that account for the scholarly influence of published books.
Uniform Sobolev estimates for non-trapping metrics
Authors: Guillarmou Colin , Hassell Andrew 
Published: October 2013

AbstractWe prove uniform Sobolev estimates $\Vert u\Vert _{{L}^{p\prime } } \leq C\Vert (\Delta - \alpha )u\Vert _{{L}^{p} } $ for $\alpha \in \mathbb{C} $ and $p= 2n/ (n+ 2), {p}^{\prime } = 2n/ (n- 2)$ on non-trapping asymptotically conic manifolds of dimension $n\geq 3$, generalizing to non-constant coefficient Laplacians a result of
Kenig, Ruiz and Sogge [13].
Decision‐making and accountability: differences of distribution
Authors: Goodwin Dawn 
Published: October 2013

AbstractThe cognitive and individual framing of clinical decision‐making has been undermined in the social sciences by attempts to reframe decision‐making as being distributed. In various ways, shifts in understanding in social science research and theorising have wrested clinical decision‐making away from the exclusive domain of medical practice and shared it throughout the healthcare disciplines. The temporality of decision‐making has been stretched from discrete moments of cognition to being incrementally built over many instances of time and place, and the contributors towards decision‐making have been expanded to include non‐humans such as policies, guidelines and technologies. However, frameworks of accountability fail to recognise this distributedness and instead emphasise independence of thought and autonomy of action. In this article I illustrate this disparity by contrasting my ethnographic accounts of clinical practice with the professional codes of practice produced by the General Medical Council and the Nursing and Midwifery Council. I argue that a ‘thicker’ concept of accountability is needed; one that can accommodate the diffuseness of decision‐making and the dependencies incurred in collaborative work.
Cessation of oral anticoagulation in relation to mortality and the risk of thrombotic events in patients with atrial fibrillation
Authors: Gallego Pilar , Roldan Vanessa , Marín Francisco , Romera Marta , Valdés Mariano , Vicente Vicente , Lip Gregory Y. H. 
Published: October 2013

SummaryBleeding risk (often perceived, rather than actual) is a common reason for cessation of oral anticoagulation with Vitamin K antagonists (VKA). We investigate clinical outcomes in a consecutive population of VKA naïve atrial fibrillation (AF) patients, who initiated VKA therapy in our clinic. We included consecutive VKA-naíve patients with non valvular AF, initiated on VKA therapy in our anticoagulation outpatient clinic in 2009. During follow-up, adverse events [thrombotic/vascular events (stroke, acute coronary syndrome, acute heart failure and cardiac death), major bleeding and death], and VKA cessation were recorded. At the end of the follow-up, we determined time within therapeutic range (TTR), using a linear approximation (Rosendaal method). We studied 529 patients (49% male, median age 76), median follow-up 835 days (IQR 719−954). During this period 114 patients stopped VKA treatment. 63 patients suffered a thrombotic/cardiovascular event (5.17%/year, 27 thrombotic/ischaemic strokes), 51 major bleeding (4.19%/year) and 48 died (3.94%/year). Median TTR was 54% (34a57). On multivariate analysis (adjusted by CHA2DS2-VASc score), VKA cessation was associated with death [Hazard Ratio (HR) 3.43; p<0.001], stroke [4.21; p=0.001] and thrombotic/cardiovascular events [2.72; p<0.001]. Independent risk factors for major bleeding were age [1.08; p<0.001], previous stroke [1.85; p=0.049], and TTR [0.97; p=0.001], but not VKA cessation. In conclusion, in AF patients AF, VKA cessation is independently associated with mortality stroke and cardiovascular events. Specifically, VKA cessation independently increased the risk of stroke, even after adjusting for CHA2DS2-VASc score. TTR was an independent risk factor for major bleeding following initiation of VKA therapy.Note: The editorial process for this paper was fully handled by Prof Christian Weber, Editor in Chief.
Splicing Boundaries: The Experiences of Bioart Exhibition
Visitors
Authors: Kerbe Wolfgang , Schmidt Markus 
Published: October 2013

ABSTRACT
Bioart can cross the line between the scientific domain and that of arts and may touch the boundary between the living and the nonliving. This study addresses how visitors to a bioart exhibition experienced the hybrid aspects of this form of art. Semi-structured interviews were held with 119 visitors to the synth-ethic exhibition in Vienna, Austria, in May and June 2011. Analysis shows that for a majority of visitors the use of bacteria and lower organisms does not pose an ethical problem, whereas integration of higher animals or even humans into the artwork is not readily accepted.
L’imagerie mentale et ses déterminants comme facteurs de réponses émotionnelles et comportementales du consommateur : une analyse en situation d’achat en ligne
Authors: Lao Aurély 
Published: October 2013

Résumé Cette recherche met en évidence l’influence positive de l’imagerie mentale de soi et de ses antécédents sur les émotions anticipées mixtes et sur l’intention et l’impulsion d’achat du e-consommateur. Les résultats montrent que le choix des stimuli utilisés dans la présentation d’un produit sur un site marchand peut influencer significativement l’imagerie mentale et les réponses comportementales de l’internaute. Des implications théoriques et managériales sont proposées ainsi que des voies de recherche issues des limites de l’étude sont soulignées.
Monitoring the immune response to vaccination with an inactivated vaccine associated to bovine neonatal pancytopenia by deep sequencing transcriptome analysis in cattle
Authors: Demasius Wiebke , Weikard Rosemarie , Hadlich Frieder , Müller Kerstin Elisabeth , Kühn Christa 
Published: October 2013

AbstractBovine neonatal pancytopenia (BNP) is a new fatal, alloimmune/alloantibody mediated disease of new-born calves induced by ingestion of colostrum from cows, which had been vaccinated with a specific vaccine against the Bovine Virus Diarrhoea Virus (BVDV). The hypothesis of pathogenic MHC class I molecules in the vaccine had been put up, but no formal proof of specific causal MHC class I alleles has been provided yet. However, the unique features of the vaccine obviously result in extremely high specific antibody titres in the vaccinated animals, but apparently also in further molecules inducing BNP. Thus, a comprehensive picture of the immune response to the vaccine is essential. Applying the novel approach of next generation RNA sequencing (RNAseq), our study provides a new holistic, comprehensive analysis of the blood transcriptome regulation after vaccination with the specific BVDV vaccine. Our RNAseq approach identified a novel cytokine-like gene in the bovine genome that is highly upregulated after vaccination. This gene has never been described before in any other species and might be specific to ruminant immune response. Furthermore, our data revealed a very coordinated immune response to double-stranded (ds) RNA or a dsRNA analogue after vaccination with the inactivated single-stranded (ss) RNA vaccine. This would suggest either a substantial contamination of the vaccine with dsRNA from host cells after virus culture or a dsRNA analogue applied to the vaccine. The first option would highlight the potential risks associated with virus culture on homologous cells during vaccine production; the latter option would emphasise the potential risks associated with immune stimulating adjuvants used in vaccine production.
Precise colocalization of interacting structural and pigmentary elements generates extensive color pattern variation in Phelsumalizards
Authors: Saenko Suzanne V , Teyssier Jérémie , van der Marel Dirk , Milinkovitch Michel C 
Published: October 2013

Abstract
Background
Color traits in animals play crucial roles in thermoregulation, photoprotection, camouflage, and visual communication, and are amenable to objective quantification and modeling. However, the extensive variation in non-melanic pigments and structural colors in squamate reptiles has been largely disregarded. Here, we used an integrated approach to investigate the morphological basis and physical mechanisms generating variation in color traits in tropical day geckos of the genus Phelsuma.

Results
Combining histology, optics, mass spectrometry, and UV and Raman spectroscopy, we found that the extensive variation in color patterns within and among Phelsuma species is generated by complex interactions between, on the one hand, chromatophores containing yellow/red pteridine pigments and, on the other hand, iridophores producing structural color by constructive interference of light with guanine nanocrystals. More specifically, we show that 1) the hue of the vivid dorsolateral skin is modulated both by variation in geometry of structural, highly ordered narrowband reflectors, and by the presence of yellow pigments, and 2) that the reflectivity of the white belly and of dorsolateral pigmentary red marks, is increased by underlying structural disorganized broadband reflectors. Most importantly, these interactions require precise colocalization of yellow and red chromatophores with different types of iridophores, characterized by ordered and disordered nanocrystals, respectively. We validated these results through numerical simulations combining pigmentary components with a multilayer interferential optical model. Finally, we show that melanophores form dark lateral patterns but do not significantly contribute to variation in blue/green or red coloration, and that changes in the pH or redox state of pigments provide yet another source of color variation in squamates.

Conclusions
Precisely colocalized interacting pigmentary and structural elements generate extensive variation in lizard color patterns. Our results indicate the need to identify the developmental mechanisms responsible for the control of the size, shape, and orientation of nanocrystals, and the superposition of specific chromatophore types. This study opens up new perspectives on Phelsuma lizards as models in evolutionary developmental biology.
Glial-specific gene alterations associated with manic behaviors
Authors: Gao Yonglin , Jhaveri Malhar , Lei Zhenmin , Chaneb Brandy L , Lingrel Jerry , El-Mallakh Rif S 
Published: October 2013

Abstract

Background
Glial dysfunction has been purported to be important to the pathophysiology of bipolar illness. However, manic behavior has not been previously demonstrated to result as a consequence of glial pathology. The aim of the current study was to assess the behaviors of the glial-specific sodium pump alpha2 subunit (ATP1A2) knockout (KO) heterozygote mice to determine if a glial-specific abnormality can produce manic-like behavior.

Methods
Activity and behavior of hemideficient sodium pump alpha2 KO mice and wild-type (WT) littermates (C57BL6/Black Swiss background) were examined at baseline, following forced swimming stress and restraint stress and after 3 days of sleep deprivation.

Results and discussion
At baseline, the 24-h total distance traveled and center time were significantly greater in KO mice, but there were no behavioral differences with sweet water preference or with inactivity time during forced swim or tail suspension tests. After restraint stress or forced swimming stress, there were no differences in activity. Three days of sleep deprivation utilizing the inverted flowerpot method induced a significant increase in the distance traveled by the KO versus WT mice in the 30-min observation period (p=0.016). Lithium pretreatment has no effect on WT animals versus their baseline but significantly reduces hyperactivity induced by sleep deprivation in KO. Knockout of the glial-specific alpha2 isoform is associated with some manic behaviors compared to WT littermates, suggesting that glial dysfunction could be associated with mania.