bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Experiment and Theory to Detect and Predict Ligand Phase Separation on Silver Nanoparticles
Authors: Farrell Zachary , Merz Steve , Seager Jon , Dunn Caroline , Egorov Sergei , Green David L. 
Published: April 2015

AbstractMALDI mass‐spectrometry measurements are combined with self‐consistent mean‐field (SCF) calculations to detect and predict ligand phase separation on Ag nanoparticles. The experimental and theoretical techniques complement each other by enabling quantification of the nearest‐neighbor distribution of a ligand mixture in a monolayer shell. By tracking a characteristic metallic fragment family, analysis of a MALDI spectrum produces a frequency distribution corresponding to specific ligand patterning. Inherent to the SCF calculation is the enumeration of local interactions that dictate ligand assembly. Interweaving MALDI and SCF facilitates a comparison between the experimentally and theoretically derived frequency distributions as well as their deviation from a well‐mixed state. Thus, we combine these techniques to detect and predict phase separation in monolayers that mix uniformly or experience varying degrees of de‐mixing, including microphase separation and stripe formation. Definition of MALDI removed as this is a commonly recognized technique.
Targeting mitosis‐regulating genes in cisplatin‐sensitive and ‐resistant melanoma cells: A live‐cell RNAi screen displays differential nucleus‐derived phenotypes
Authors: Erfle Holger , Pashayeva K. , Harder N. , Zhang L. , Rohr K. , Schadendorf D. , Ugurel S. , Keese M. 
Published: April 2015

AbstractChemoresistance in malignant melanoma remains an unresolved clinical issue. In the search for novel molecular targets, a live‐cell high‐content RNAi screen based on gene expression data was performed in cisplatin‐sensitive and cisplatin‐resistant MeWo melanoma cells, Mel‐28 cells and a melanocyte cell line. Cells were exposed to 91 siRNAs and distinct nucleus‐derived phenotypes such as cell division, cell death and migration phenotypes were detected by time‐lapse microscopy over 60 h. Using this approach, cisplatin‐sensitive and cisplatin‐resistant melanoma cells were compared by automated image analysis and visual inspection. In cisplatin‐sensitive MeWo melanoma cells, 14 genes were identified that showed distinct phenotype abnormalities after exposure to gene‐specific siRNAs. In cisplatin‐resistant MeWo cells, five genes were detected. Nine genes were detected whose knock‐down led to differential nuclear phenotypes in cisplatin‐sensitive and ‐resistant cells. In Mel‐28 cells, nine genes were identified which induced nuclear phenotypes including all eight genes which were identified in cisplatin‐resistant MeWo cells. An analogous RNAi screen on melanocytes revealed no detectable phenotype abnormalities after RNAi. Pathway analysis showed in cisplatin‐sensitive MeWo cells and Mel‐28 cells an enrichment of at least three genes in major mitotic pathways. We hereby show that siRNA screening may help to identify tumor‐specific genes leading to phenotype abnormalities. These genes may serve as potential therapeutic targets in the treatment of melanoma.
Chemical Composition and Allelopathic Potential of Essential Oils Obtained from Acacia cyanophyllaLindl. Cultivated in Tunisia
Authors: El Ayeb‐Zakhama Asma , Sakka‐Rouis Lamia , Bergaoui Afifa , Flamini Guido , Ben Jannet Hichem , Harzallah‐Skhiri Fethia 
Published: April 2015

AbstractAcacia cyanophylla Lindl. (Fabaceae), synonym Acacia saligna (Labill.) H. L.Wendl., native to West Australia and naturalized in North Africa and South Europe, was introduced in Tunisia for rangeland rehabilitation, particularly in the semiarid zones. In addition, this evergreen tree represents a potential forage resource, particularly during periods of drought. A. cyanophylla is abundant in Tunisia and some other Mediterranean countries. The chemical composition of the essential oils obtained by hydrodistillation from different plant parts, viz., roots, stems, phyllodes, flowers, and pods (fully mature fruits without seeds), was characterized for the first time here. According to GC‐FID and GC/MS analyses, the principal compound in the phyllode and flower oils was dodecanoic acid (4), representing 22.8 and 66.5% of the total oil, respectively. Phenylethyl salicylate (8; 34.9%), heptyl valerate (3; 17.3%), and nonadecane (36%) were the main compounds in the root, stem, and pod oils, respectively. The phyllode and flower oils were very similar, containing almost the same compounds. Nevertheless, the phyllode oil differed from the flower oil for its higher contents of hexahydrofarnesyl acetone (6), linalool (1), pentadecanal, α‐terpineol, and benzyl benzoate (5) and its lower content of 4. Principal component and hierarchical cluster analyses separated the five essential oils into four groups, each characterized by its main constituents. Furthermore, the allelopathic activity of each oil was evaluated using lettuce (Lactuca sativa L.) as a plant model. The phyllode, flower, and pod oils exhibited a strong allelopathic activity against lettuce.
Synthesis and Biological Evaluation of Novel Oxazolo[5,4‐d]pyrimidines as Potent VEGFR‐2 Inhibitors
Authors: Deng Ya‐Hui , Xu Dan , Su Ye‐Xiang , Cheng Yi‐Juan , Yang Yan‐Li , Wang Xiu‐Yun , Zhang Juan , You Qi‐Dong , Sun Li‐Ping 
Published: April 2015

AbstractTumor angiogenesis is mediated by vascular endothelial growth factor receptor (VEGFR) and other protein kinases. Inhibition of these kinases presents an attractive approach for developing anticancer therapeutics. In this work, a series of 2,5,7‐trisubstituted oxazolo[5,4‐d]pyrimidines were synthesized, and their inhibitory activities were investigated against VEGFR‐2 and human umbilical vein endothelial cells (HUVEC) in vitro. Compound 9n exhibited the most potent inhibitory activity with IC50 values of 0.33 and 0.29 μM for VEGFR‐2 kinase and HUVEC, respectively. A further kinase selectivity assay revealed that these compounds exhibit good VEGFR and moderate EGFR inhibitory activities. Docking analysis suggested a common mode of interaction at the ATP‐binding site of VEGFR‐2.
Potential of Proapoptotic Peptides to Induce the Formation of Giant Plasma Membrane Vesicles with Lipid Domains
Authors: Lauster Daniel , Vazquez Olalla , Schwarzer Roland , Seitz Oliver , Herrmann Andreas 
Published: April 2015

AbstractWe have established a method of preparing giant plasma membrane vesicles (GPMVs) by using cysteine mutants of the proapoptotic peptide (PAP) Ac‐R7‐GG‐KLAKLAKKLAKLAK. A cysteine scan revealed that cytotoxicity and GPMV formation were dependent on the cysteine position within the PAP sequence. In comparison to GPMVs prepared by extensive treatment with paraformaldehyde (PFA) and dithiothreitol (DTT), our GPMVs were produced from HeLa cells at much lower concentrations of the blebbing agent. We found that only GPMVs derived from cysteine‐containing PAP showed lipid phase separation. This membrane model was applied to investigate the phase partitioning of two relevant membrane proteins: influenza virus hemagglutinin (HA) and tetherin, which clamps budding HIV to infected cells. For tetherin, we show for the first time exclusion from cholesterol‐rich domains in a GPMV model, thus documenting the potential of our approach for membrane‐partitioning studies.
Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway
Authors: Cano‐Prieto Carolina , García‐Salcedo Raúl , Sánchez‐Hidalgo Marina , Braña Alfredo F. , Fiedler Hans‐Peter , Méndez Carmen , Salas José A. , Olano Carlos 
Published: April 2015

AbstractStreptomyces sp. Tü 6176 produces the cytotoxic benzoxazole nataxazole. Bioinformatic analysis of the genome of this organism predicts the presence of 38 putative secondary‐metabolite biosynthesis gene clusters, including those involved in the biosynthesis of AJI9561 and its derivative nataxazole, the antibiotic hygromycin B, and ionophores enterobactin and coelibactin. The nataxazole biosynthesis gene cluster was identified and characterized: it lacks the O‐methyltransferase gene required to convert AJI9561 into nataxazole. This O‐methyltransferase activity might act as a resistance mechanism, as AJI9561 shows antibiotic activity whereas nataxazole is inactive. Moreover, heterologous expression of the nataxazole biosynthesis gene cluster in S. lividans JT46 resulted in the production of AJI9561. Nataxazole biosynthesis requires the shikimate pathway to generate 3‐hydroxyanthranilate and an iterative type I PKS to generate 6‐methylsalicylate. Production of nataxazole was improved up to fourfold by disrupting one regulatory gene in the cluster. An additional benzoxazole, 5‐hydroxynataxazole is produced by Streptomyces sp. Tü 6176. 5‐Hydroxynataxazole derives from nataxazole by the activity of an as yet unidentified oxygenase; this implies cross‐talk between the nataxazole biosynthesis pathway and an unknown pathway.
ChemInform Abstract: Crystal Structure of Tin(II) Perchlorate Trihydrate.
Authors: Hennings Erik , Schmidt Horst , Koehler Martin , Voigt Wolfgang 
Published: April 2015

Abstract[Sn(H2O)3](ClO4)2 is prepared by the redox reaction of Cu(ClO4)2 and Sn in HClO4 followed by crystallization in a freezer (253 K).
ChemInform Abstract: Crystal Structures of Sr(ClO4)2·3H2O (I), Sr(ClO4)2·4H2O (II) and Sr(ClO4)2·9H2O (III).
Authors: Hennings Erik , Schmidt Horst , Voigt Wolfgang 
Published: April 2015

AbstractSingle crystals of the title compound are obtained from low temperature solutions according to the solid‐liquid phase diagram.
ChemInform Abstract: Inherent Electrochemistry of Layered Post‐Transition Metal Halides: The Unexpected Effect of Potential Cycling of PbI2.
Authors: Chua Chun Kiang , Sofer Zdenek , Lim Chee Shan , Pumera Martin 
Published: April 2015

AbstractElectrochemical potential cycling of PbI2 in phosphate buffer leads to the formation of Pb5(PO4)3Cl with hexagonal symmetry (space group P63/m, apatite‐type structure).
ChemInform Abstract: Hydrodeoxygenation of Vicinal OH Groups over Heterogeneous Rhenium Catalyst Promoted by Palladium and Ceria Support.
Authors: Ota Nobuhiko , Tamura Masazumi , Nakagawa Yoshinao , Okumura Kazu , Tomishige Keiichi 
Published: April 2015

AbstractHeterogeneous ReOx—Pd/CeO2 catalyst shows excellent performance for simultaneous hydrodeoxygenation of vicinal OH groups.
ChemInform Abstract: Utility of Enaminonitriles in Heterocyclic Synthesis: Synthesis of Some New Azepine, Azocine, and Pyrroldione Derivatives.
Authors: Fadda Ahmed A. , Elattar Khaled M. 
Published: April 2015

AbstractEnaminonitrile derivative (III) is used as starting material for the synthesis of a variety of heterocyclic compounds.
ChemInform Abstract: Silicon‐Directed Rhenium‐Catalyzed Allylic Substitutions with N‐Hydroxycarbamates, N‐Hydroxysulfonamides, and Hydroxamic Acids.
Authors: Chavhan Sanjay W. , McAdam Catherine A. , Cook Matthew J. 
Published: April 2015

AbstractIn case of Cbz‐protected hydroxylamine excellent N/O‐selectivities up to 99:1 are observed.
ChemInform Abstract: Stereocontrolled O‐Glycosylation with Palladium‐Catalyzed Decarboxylative Allylation.
Authors: Xiang Shaohua , He Jingxi , Tan Yu Jia , Liu Xue‐Wei 
Published: April 2015

AbstractStarting from glucal derived carbonate (I), various O‐glycosides are stereoselectively formed trough Pd‐catalyzed tandem decarboxylation, proton abstraction, and nucleophilic addition.
ChemInform Abstract: Difluoromethylene Phosphabetaine as an Equivalent of Difluoromethyl Carbanion.
Authors: Levin Vitalij V. , Trifonov Alexey L. , Zemtsov Artem A. , Struchkova Marina I. , Arkhipov Dmitry E. , Dilman Alexander D. 
Published: April 2015

AbstractA nucleophilic difluoromethylation of reactive Michael acceptors, aldehydes, and azomethines is described.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of Benzyl Chlorides with Cyclopropanol‐Derived Ketone Homoenolates.
Authors: Nithiy Nisha , Orellana Arturo 
Published: April 2015

AbstractThe scalable method delivers good reaction yields using various cyclopropanols and electron‐rich or electron‐neutral benzyl chloride.
ChemInform Abstract: Electronic Tuning Cyclization of Aryl‐1,4‐enediones: AlCl3‐Mediated Nazarov‐Type Cyclization to Synthesize Polysubstituted‐1‐indanones.
Authors: Zhu Yan‐Ping , Cai Qun , Jia Feng‐Cheng , Liu Mei‐Cai , Gao Qing‐He , Meng Xiang‐Gao , Wu An‐Xin 
Published: April 2015

AbstractSubstrates (I) with aroyls, esters and conjugated enones attached to the 5‐position require two or more electron donating methoxy groups at the aryl ring to promote the reaction.
ChemInform Abstract: Synthesis of Phenanthridine Derivatives Functionalized in the C‐Ring by Means of IMDAF Reactions under Microwave or Conventional Heating Conditions.
Authors: Gulbrandsen Haakon Saetren , Hennum Martin , Osheka Maksim , Read Matthew Lovell , Gundersen Lise‐Lotte 
Published: April 2015

AbstractThe results of the intramolecular reactions of substrates (I) and (VII) are highly dependent on the substituents and on the reaction conditions.
ChemInform Abstract: Synthesis of Dispirocyclopentyl‐3,3′‐bisoxindoles via Base Promoted Cyclization Reaction of 3‐Phenacylideneoxindoles with Nitromethane.
Authors: Lu Li‐Juan , Yan Chao‐Guo 
Published: April 2015

AbstractThe title reaction has the advantages of readily available starting materials, operational simplicity, good yields, and high diastereoselectivity.
ChemInform Abstract: A Highly Diastereoselective Synthesis of Chroman Derivatives Bearing Spirocyclic N,O‐Acetals Skeleton via a One‐Pot Tandem Reaction.
Authors: Zhou Yu , Zhou Kai‐Da , Xu Xiao‐Ping , Zhu Ya‐Nan , Wu Zhen , Ji Shun‐Jun 
Published: April 2015

AbstractThe nitrobenzoic acid‐mediated reaction of phenols, formaldehyde, and benzylimidazolidinones furnishes spirochroman derivatives in moderate to good yields and good to excellent diastereoselectivities.
ChemInform Abstract: Benzofuran—Chalcone Hybrids as Potential Multifunctional Agents Against Alzheimer′s Disease: Synthesis and in vivo Studies with Transgenic Caenorhabditis elegans.
Authors: Sashidhara Koneni V. , Modukuri Ram K. , Jadiya Pooja , Dodda Ranga Prasad , Kumar Manoj , Sridhar Balasubramaniam , Kumar Vikash , Haque Rizwanul , Siddiqi Mohammad Imran , Nazir Aamir 
Published: April 2015

AbstractA series of novel hybrid compounds incorporating benzofuran and chalcone fragments (V) are designed, synthesized and evaluated as potential agents against Alzheimer′s disease.
ChemInform Abstract: Pd‐Catalyzed C—H Carbonylation of (Hetero)arenes with Formates and Intramolecular Dehydrogenative Coupling: A Shortcut to Indolo[3,2‐c]coumarins.
Authors: Wu Jie , Lan Jingbo , Guo Siyuan , You Jingsong 
Published: April 2015

AbstractThe reaction tolerates N‐protected and N‐unprotected, substituted and unsubstituted indole derivatives as well as arenes and heteroarenes such as indolizines, pyrroles and electron rich benzol derivatives.
ChemInform Abstract: An Unexpected Role of Carbon Disulfide: A New and Efficient Method for the Synthesis of 2‐Substituted Benzimidazoles.
Authors: Gladysz John A. , Reza Safaei Hamid , Nouri Sara 
Published: April 2015

AbstractCS2 unexpectedly facilitates the synthesis of 2‐arylbenzimidazoles via intermolecular cyclization reaction of benzene‐1,2‐diamines and aromatic aldehydes.
ChemInform Abstract: Novel Copper/PEG‐400 Catalyst Systems for Chemoselective S‐ and N‐Arylation of 2‐Mercaptobenzothiazole.
Authors: Li Xiaokang , Yuan Tangjun , Yang Yu , Chen Junmin 
Published: April 2015

AbstractDepending on copper compound catalyst, base and temperature 2‐mercaptobenzothiazole is arylated with aromatic halides at the thiol‐S or the ring‐N atom.
ChemInform Abstract: Prins—Arylthiolation Reaction on Terpenoids: Diastereoselective Synthesis of 4‐Arylthiooctahydro‐2H‐chromenes.
Authors: Sarmah Barnali , Baishya Gakul , Baruah Rajani K. 
Published: April 2015

Abstract(‐)‐Isopulegol undergoes Prins‐arylthiolation with aldehydes and cyclohexanone in the presence of HBF4·OEt2 to generate a library of 4‐arylthio‐octahydro‐2H‐chromene derivatives in good to excellent yields with moderate to high cis selectivity at ambient temperature in CH2Cl2.
ChemInform Abstract: A Stereoselective Switch: Enantiodivergent Approach to the Synthesis of Isoflavanones.
Authors: Doran Robert , Carroll Michael P. , Akula Ramulu , Hogan Bryan F. , Martins Marta , Fanning Seamus , Guiry Patrick J. 
Published: April 2015

AbstractA modular sequence to construct isoflavones with a range of methoxy‐substituted aryl substituents is presented.
ChemInform Abstract: Antibacterial Activities of Novel Nicotinic Acid Hydrazides and Their Conversion into N‐Acetyl‐1,3,4‐oxadiazoles.
Authors: Morjan Rami Y. , Mkadmh Ahmed M. , Beadham Ian , Elmanama Abdelrauof A. , Mattar Mohammed R. , Raftery James , Pritchard Robin G. , Awadallah Adel M. , Gardiner John M. 
Published: April 2015

AbstractA wide range of novel N‐acylhydrazones of nicotinic acid hydrazides (III), (VII) is synthesized and transformed into corresponding oxadiazoles by simple reflux in Ac2O.
ChemInform Abstract: Highly Efficient Modular Metal‐Free Synthesis of 3‐Substituted 2‐Quinolones
Authors: Aksenov Alexander V. , Smirnov Alexander N. , Aksenov Nicolai A. , Aksenova Inna V. , Bijieva Asiyat S. , Rubin Michael 
Published: April 2015

Abstractby a cascade annulation of aryl hydrazines with nitroketones in PPA
ChemInform Abstract: Metal‐Free Preparation of 6‐Alkylthiophenanthridines via Oxidative C—S and C—C Bond Formation from 2‐Isocyanobiphenyls and Disulfides.
Authors: Fang Hong , Zhao Jincan , Qian Ping , Han Jianlin , Pan Yi 
Published: April 2015

AbstractThis isocyanide thiolation/intramolecular radical aromatic cyclization sequence tolerates various functional groups and gives good to excellent yields.
ChemInform Abstract: A Temporary‐Bridge Strategy for Enantioselective Organocatalyzed Synthesis of Aza‐Seven‐Membered Rings.
Authors: Goudedranche Sebastien , Pierrot David , Constantieux Thierry , Bonne Damien , Rodriguez Jean 
Published: April 2015

AbstractThe first enantioselective domino synthesis of azepane moieties is reported.
ChemInform Abstract: Seven‐ and Eight‐Membered Heterocyclic Biaryl Synthesis Through a Metal‐Free Oxidative Coupling Reaction.
Authors: Sun Shutao , Yang Jingjing , Li Fanmei , Lv Zheng , Li Wei , Lou Hongxiang , Liu Lei 
Published: April 2015

AbstractThe method is applicable to the synthesis of nitrogen, oxygen, sulfur and only carbon containing seven‐ and eight‐membered tricyclic ring systems starting from electron‐rich biaromatic compounds, but fails using bianisole derived substrates.
ChemInform Abstract: Rhodium(III)‐Catalyzed Olefinic C—H Alkynylation of Acrylamides Using Tosyl‐Imide as Directing Group.
Authors: Feng Chao , Feng Daming , Luo Yang , Loh Teck‐Peng 
Published: April 2015

AbstractThe synthetic utility of the methodology is demonstrated by the representative derivatization of one product [cf.
ChemInform Abstract: A Unique 1,2‐Acyl Migration for the Construction of Quaternary Carbon by Visible Light Irradiation of Platinum(II) Polypyridyl Complex and Molecular Oxygen.
Authors: Meng Qing‐Yuan , Lei Tao , Zhao Lei‐Min , Wu Cheng‐Juan , Zhong Jian‐Ji , Gao Xue‐Wang , Tung Chen‐Ho , Wu Li‐Zhu 
Published: April 2015

AbstractEnamines (I) react with molecular oxygen and alcohols in the presence of platinum catalyst PTP under irradiation with blue LEDs to form α‐trisubstituted esters.
ChemInform Abstract: Enantioselective Total Syntheses of Citrinadins A and B. Stereochemical Revision of Their Assigned Structures.
Authors: Bian Zhiguo , Marvin Christopher C. , Pettersson Martin , Martin Stephen F. 
Published: April 2015

AbstractStarting from commercially available materials the enantioselective 20 and 21 step syntheses of (‐)‐citrinadin A and (+)‐citrinadin B result in revison of the structures of the natural materials to (Ia) and (Ib).
ChemInform Abstract: Amphidinins C—F, Amphidinolide Q Analogues from Marine Dinoflagellate Amphidinium sp.
Authors: Kubota Takaaki , Iwai Takahiro , Sakai Kanae , Gonoi Tohru , Kobayashi Jun'ichi 
Published: April 2015

AbstractAmphidinin C (Ia), D (Ib), E (IIa) and F (IIb) are evaluated for their antimicrobial activity against several bacteria and fungi as well as their cytotoxicity.
ChemInform Abstract: Synthesis and Antibacterial Activity of Some Novel 4‐Oxopyrido[2,3‐a]phenothiazines.
Authors: Al‐Sinjilawi Hadeel T. , El‐Abadelah Mustafa M. , Mubarak Mohammad S. , Al‐Aboudi Amal , Abadleh Mohammed M. , Mahasneh Adel M. , Ahmad Asaad K. M. A. 
Published: April 2015

AbstractCompounds (I) are prepared and evaluated towards their antibacterial activity with (Ia) showing the highest activity.
ChemInform Abstract: Recent Progress in the Lewis Acid Co‐Initiated Cationic Polymerization of Isobutylene and 1,3‐Dienes
Authors: Kostjuk Sergei V. 
Published: April 2015

AbstractReview: [recent approaches towards the synthesis of exo‐olefin terminated polyisobutylenes and well‐defined poly(1‐3‐diene)s; 94 refs.
Eco‐Friendly Solvents for Palladium‐Catalyzed Desulfitative CH Bond Arylation of Heteroarenes
Authors: Hfaiedh Anoir , Yuan Kedong , Ben Ammar Hamed , Ben Hassine Bechir , Soulé Jean‐François , Doucet Henri 
Published: April 2015

AbstractHerein, we report the Pd‐catalyzed regioselective direct arylation of heteroarenes in which benzenesulfonyl chlorides are used as coupling partners through a desulfitative cross‐coupling that can be performed in diethyl carbonate (DEC) or cyclopentyl methyl ether (CPME) as green and renewable solvents or even in neat conditions instead of dioxane or dimethylacetamide (DMA). Under these solvent conditions, the reaction proceeds with a wide range of heteroarenes. C2‐ or C5‐arylated products were obtained with furan and pyrrole derivatives. Benzofuran was also arylated regioselectively at the C2‐position, whereas the reaction proceeds selectively at the C3‐ or C4‐positions if thiophenes and benzothiophenes are used. Moreover, in some cases, especially with 1‐methylindole, solvent‐free conditions afforded better regioselectivities and/or yields than the reaction performed in the presence of solvents.
Amperometric Biosensor for Choline Based on Gold Screen‐Printed Electrode Modified with Electrochemically‐Deposited Silica Biocomposite
Authors: Mazurenko I. , Tananaiko O. , Biloivan O. , Zhybak M. , Pelyak I. , Zaitsev V. , Etienne M. , Walcarius A. 
Published: April 2015

AbstractA mediator‐free choline biosensor was developed using the electrochemically assisted sol‐gel deposition on gold screen‐printed electrodes. The addition of 12 mM of cationic surfactant CTAB in silica sol allowed enhancing the stability of the sensor. The modified electrode demonstrated catalytic activity and stable amperometric response to choline for over 3 weeks of exploitation with the sensitivity of 6 µA mM−1 and LOD of 6 µM. The interference of ascorbic acid was reduced by pretreating the analyzed solution with MnO2 powder. The application of the sensor with the purpose of identifying choline in the baby milk demonstrated satisfactory metrological characteristics.
Cottoquinazolines E and F from Neosartorya fischeri NRRL 181
Authors: Shan Wei‐Guang , Wang Shi‐Lei , Lang Huang‐Yan , Chen Si‐Mei , Ying You‐Min , Zhan Zha‐Jun 
Published: April 2015

AbstractTwo new norfumiquinazolines, cottoquinazolines E and F (1 and 2, resp.), together with pyripyropene A (3), were isolated from the fungus Neosartorya fischeri NRRL 181. The structures of the new isolates were established by spectroscopic methods, including UV, IR, HR‐ESI‐MS, and extensive 1D‐ and 2D‐NMR techniques. To the best of our knowledge, this is the first report on norfumiquinazolines and pyripyropenes produced by the genus Neosartorya.