bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Opinions of Users of the Tripadvisor Web Platform on the Cultural Tourism Resources of Málaga
Authors: Soto-Rumiche Marco Antonio , Caro José Luis 
Published: June 2024

AbstractThis study analyses the experiences of visitors to cultural tourism resources in the municipality of Malaga (Spain) through sentiment analysis. The online reviews shared by visitors on TripAdvisor and other platforms are relevant to know the valuation of users, being an influencing factor in decision-making by other users. The aim of this research work is to shed light on the online reputation of the cultural heritage of the city of Málaga through reviews on social networks or TripAdvisor opinion web platforms. The basis of the study were the reviews issued by TripAdvisor users, expressing the satisfaction and emotions experienced in the experiences at the destination, focusing interest on museum exhibitions, and highlighting the architectural spaces that complement the visit. Likewise, our results highlight that the emotions and feelings experienced are mostly positive in visits to heritage monuments, highlighting the historical value and the synergy with green areas as an ideal complement that make up the urban landscape of the city of Malaga. The findings of this study will not only contribute to the existing literature on consumer behaviour towards online reviews but may also provide valuable information for organisations involved in the cultural tourism sector.
Voltammetric detection of Neuropeptide Y using a modified sawhorse waveform
Authors: Alyamni Nadiah , Abot Jandro L. , Zestos Alexander G. 
Published: June 2024

AbstractThe hormone Neuropeptide Y (NPY) plays critical roles in feeding, satiety, obesity, and weight control. However, its complex peptide structure has hindered the development of fast and biocompatible detection methods. Previous studies utilizing electrochemical techniques with carbon fiber microelectrodes (CFMEs) have targeted the oxidation of amino acid residues like tyrosine to measure peptides. Here, we employ the modified sawhorse waveform (MSW) to enable voltammetric identification of NPY through tyrosine oxidation. Use of MSW improves NPY detection sensitivity and selectivity by reducing interference from catecholamines like dopamine, serotonin, and others compared to the traditional triangle waveform. The technique utilizes a holding potential of −0.2 V and a switching potential of 1.2 V that effectively etches and renews the CFME surface to simultaneously detect NPY and other monoamines with a sensitivity of 5.8 ± 0.94 nA/µM (n = 5). Furthermore, we observed adsorption-controlled, subsecond NPY measurements with CFMEs and MSW. The effective identification of exogenously applied NPY in biological fluids demonstrates the feasibility of this methodology for in vivo and ex vivo studies. These results highlight the potential of MSW voltammetry to enable fast, biocompatible NPY quantification to further elucidate its physiological roles.
Graphical Abstract
An Extremely Sensitive Ultra-High Throughput Growth Selection Assay for the Identification of Amidase Activity
Authors: Branson Yannick , Schnell Bjarne , Zurr Celine , Bayer Thomas , Badenhorst Christoffel P.S. , Wei Ren , Bornscheuer Uwe T. 
Published: June 2024

Abstract
In the last decades, biocatalysis has offered new perspectives for the synthesis of (chiral) amines, which are essential building blocks for pharmaceuticals, fine and bulk chemicals. In this regard, amidases have been employed due to their broad substrate scope and their independence from expensive cofactors. To expand the repertoire of amidases, tools for their rapid identification and characterization are greatly demanded. In this work an ultra-high throughput growth selection assay based on the production of the folate precursor p-aminobenzoic acid (PABA) is introduced to identify amidase activity. PABA-derived amides structurally mimic the broad class of commonly used chromogenic substrates derived from p-nitroaniline. This suggests that the assay should be broadly applicable for the identification of amidases. Unlike conventional growth selection assays that rely on substrates as nitrogen or carbon source, our approach requires PABA in sub-nanomolar concentrations, making it exceptionally sensitive and ideal for engineering campaigns that aim at enhancing amidase activities from minimally active starting points, for example. The presented assay offers flexibility in the adjustment of sensitivity to suit project-specific needs using different expression systems and fine-tuning with the antimetabolite sulfathiazole. Application of this PABA-based assay facilitates the screening of millions of enzyme variants on a single agar plate within two days, without the need for laborious sample preparation or expensive instruments, with transformation efficiency being the only limiting factor.

Key points
• Ultra-high throughput assay (tens of millions on one agar plate) for amidase screening
• High sensitivity by coupling selection to folate instead of carbon or nitrogen source
• Highly adjustable in terms of sensitivity and expression of the engineering target
Placental neutrophil reverse trans-migration and maternal serum neutrophil extracellular trap expression in HIV infection co-morbid pre-eclampsia in women of African ancestry
Authors: Moodley Merantha , Moodley Jagidesa , Naicker Thajasvarie 
Published: June 2024

AbstractNeutrophil extracellular traps (NETs) and placental neutrophil reverse transmigration (r-TM) are implicated in the pathogenesis of pre-eclampsia (PE). However, the role of the comorbidity of PE and human immunodeficiency virus (HIV) infection in placental neutrophil r-TM and serum NETs remains unknown. Human placental tissue (n = 160) and serum (n = 80) samples were obtained post-ethical approval and divided by pregnancy type and HIV status and across the study population. Immunohistochemistry and morphometry were performed to localize and quantify junctional adhesion molecule-C (JAM-C) expression as an inverse marker of neutrophil r-TM within placental villi. An enzyme-linked immunosorbent assay (ELISA) was performed to quantify the concentration of citrullinated histone H3 (cit-H3) as a marker of NETs. GraphPad Prism (version 8.0.2) was used to compare the results, and a p value of p < 0.05 was considered statistically significant. The localization of JAM-C was observed on the syncytiotrophoblasts (STBs) and endothelial cells of placental villi. The immunoexpression of JAM-C was elevated in PE vs. normotensive (N) placentae. In the exchange villi, JAM-C immunoexpression was higher in the N+ve vs. N-ve group. However, in PE comorbid HIV infection, JAM-C expression was lower in the PE+ve vs. PE-ve group. Citrullinated histone-H3 concentration was lower in the N+ve vs. N-ve group but elevated in early-onset PE (EOPE)+ve vs. late-onset PE (LOPE)+ve group. These results indicate that PE and HIV-infected placentae individually express elevated JAM-C, manifesting in less neutrophil r-TM. However, in exchange villi of PE comorbid with HIV infection reduced JAM-C enhances neutrophil r-TM, thus supporting the synergistic effect of PE comorbid with HIV.
Endoscopic submucosal dissection versus endoscopic mucosal resection for the treatment of rectal lesions involving the dentate line
Authors: Kouladouros Konstantinos , Jakobs Johanna , Stathopoulos Petros , Kähler Georg , Belle Sebastian , Denzer Ulrike 
Published: June 2024

Abstract
Background
The ideal treatment of epithelial neoplastic rectal lesions involving the dentate line is a controversial issue. Piecemeal endoscopic mucosal resection (EMR) is the most commonly used resection technique, but it is associated with high recurrence rates. Endoscopic submucosal dissection (ESD) has been shown to be safe and effective for the treatment of rectal lesions, but evidence is lacking concerning its application close to the dentate line. The aim of our study is to compare ESD and EMR for the treatment of epithelial rectal lesions involving the dentate line.

Methods
We identified all cases of endoscopic resections of rectal lesions involving the dentate line performed in two German high-volume centers between 2010 and 2022. Periinterventional and follow-up data were collected and retrospectively analyzed.

Results
We identified 68 ESDs and 62 EMRs meeting our inclusion criteria. ESD showed a significant advantage in en bloc resection rates (89.7% vs. 9.7%; P = 0.001) and complete resection rates (72.1% vs. 9.7%; P = 0.001). The overall curative resection rate was similar between both groups (ESD: 92.6%, EMR: 83.9%; P = 0.324), whereas in the subgroup of low-risk adenocarcinomas ESD was curative in 100% of the cases vs. 14% in the EMR group (P = 0.002). There was one local recurrence after ESD (1,5%) vs. 16 (25.8%) after EMR (P < 0.0001), and the EMR patients required an average of three further interventions.

Conclusion
ESD is superior to EMR for the treatment of epithelial rectal lesions involving the dentate line and should be considered the treatment of choice.
Prevalence of weakness and factors mediating discrepancy between reported and observed leg weakness in people with sciatica
Authors: Dove Lucy , Baskozos Georgios , Kelly Thomas , Buchanan Elaine , Schmid Annina B. 
Published: June 2024

Abstract
Purpose
To establish the prevalence and agreement between reported and observed leg weakness in people with sciatica. To establish which factors mediate any identified difference between reported and observed leg weakness in people with sciatica.

Methods
68 people with a clinical diagnosis of sciatica, records from spinal service, secondary care NHS Hospital, England, UK reviewed. Primary outcome measures were the sciatica bothersome index for reported leg weakness and the Medical Research Council scale for observed weakness. Agreement was established with Cohen’s Kappa and intraclass correlation coefficient. Potential factors that may mediate a difference between reported and observed weakness included leg pain, sciatica bothersome index sensory subscale, age, hospital anxiety and depression subscale for anxiety.

Results
85% of patients reported weakness but only 34% had observed weakness. Cohen’s Kappa (0.066, 95% CI − 0.53, 0.186; p = 0.317)] and ICC 0.213 (95% CI − 0.26, 0.428, p = 0.040) both showed poor agreement between reported and observed weakness. The difference between reported and observed measures of weakness was mediated by the severity of leg pain (b = 0.281, p = 0.024) and age (b = 0.253, p = 0.042).

Conclusion
There is a high prevalence of reported leg weakness in people with sciatica, which is not reflected in observed clinical measures of weakness. Differences between reported and observed weakness may be driven by the severity of leg pain and age. Further work needs to establish whether other objective measures can detect patient reported weakness.
A fix and optimize method based approximate dynamic programming approach for the strategic fleet sizing and delivery planning problem
Authors: Aghazadeh Duygu , Ertogral Kadir 
Published: June 2024

Abstract
Logistics related costs constitute a major part in total cost of a product in general. Considering a company that delivers goods to its customers using its owned fleet, fleet ownership and operational costs together with the inventory costs compose the total logistics costs. In this study, we suggest an approximate Dynamic Programming algorithm, with a look ahead strategy, that uses the fix and optimize method as the imbedded heuristic for solving integrated fleet composition and replenishment planning problem. The total annual distribution cost factors considered in the problem are vehicle ownership costs, approximate routing costs, and inventory related costs. In this problem, we aim to minimize the total logistic cost by optimizing the fleet composition, replenishment patterns, and customers assigned to each vehicle in the fleet. We produced a set of reasonably large instances randomly and showed the efficacy of the suggested solution method.
Fear of failure and academic satisfaction: the mediating role of emotion regulation difficulties and procrastination
Authors: Duru Erdinç , Balkis Murat , Duru Sibel 
Published: June 2024

AbstractThis study investigates the mediating mechanisms that play a crucial role in the relationship between fear of failure and academic satisfaction and between fear of failure and procrastination. The study sample consists of 292 undergraduate students enrolled in different departments of the university. Within the scope of this study, emotion regulation difficulties may be one of the mediating mechanisms in this reciprocal relationship, the findings provide evidence that procrastination functions as a mediating variable in the relationship between fear of failure, difficulty in emotion regulation, and academic satisfaction while difficulty in emotion regulation acts as a mediator in the relationship between fear of failure and procrastination. Therefore, the findings of this study suggest that interventions aimed at improving the individual's emotion regulation skills may play an important role in overcoming the negative effects associate with the fear of failure on procrastination and academic satisfaction.
Invariant manifolds near $$L_1$$ and $$L_2$$ in the Sun–Jupiter elliptic restricted three-body problem I
Authors: Duarte Gladston , Jorba Àngel 
Published: June 2024

AbstractIn this paper, we present a way of combining the computation of invariant tori and their stable and unstable manifolds with the multiple shooting technique. We start by showing some of the results of Jorba (Nonlinearity 14(5):943–976, 2001) that should be modified in order to introduce the multiple shooting technique in these computations. After that, by a direct application in the planar elliptic restricted three-body problem (PERTBP), how to modify the equations and methods to compute the above-mentioned objects is introduced. In particular, the structure of the (systems of) equations and matrices involved in these computations is shown. An application of these computations can be found in Duarte and Jorba (Invariant manifolds of tori near $${L}_1$$

L
1

and $${L}_2$$

L
2

in the planar elliptic restricted three-body problem II. The Dynamics of Comet Oterma, Preprint 2023), where the dynamics of comet 39P/Oterma is modelled as a PERTBP.
The impact of measured income uncertainty on Spanish household consumption at the end of the Great Recession
Authors: Lugilde Alba 
Published: June 2024

AbstractThe aim of this paper is to study empirically the existence of precautionary saving in Spain at the end of the Great Recession using the micro data provided by the Spanish Survey of Household Finances. Using the panel component of these data, I construct a measure of income uncertainty for each household from the observed household real income and use it to test for the strength of precautionary saving. I find that an increase of 1% in the standard deviation of income reduces household consumption by 8.8% when using the logarithm of the household consumption as dependent variable; however, when using the ratio between consumption and average income as dependent variable, given the average normal income and consumption in the sample, consumption will decrease by 8.1%.
Graph realization of sets of integers
Authors: Wawrzyniak Piotr , Formanowicz Piotr 
Published: June 2024

AbstractGraph theory is used in many areas of chemical sciences, especially in molecular chemistry. It is particularly useful in the structural analysis of chemical compounds and in modeling chemical reactions. One of its applications concerns determining the structural formula of a chemical compound. This can be modeled as a variant of the well-known graph realization problem. In the classical version of the problem, a sequence of natural numbers is given, and the question is whether there exists a graph in which the vertices have degrees equal to the given numbers. In the variant considered in this paper, instead of a sequence of natural numbers, a sequence of sets of natural numbers is given, and the question is whether there exists a multigraph such that each of its vertices has a degree equal to a number from one of the sets. This variant of the graph realization problem matches the nature of the problem of determining the structural formula of a chemical compound better than other variants considered in the literature. We propose a polynomial time exact algorithm solving this variant of the problem.
Seismo-stratigraphic and morpho-bathymetric analysis revealing recent fluid-rising phenomena on the Adventure Plateau (northwestern Sicily Channel)
Authors: Maiorana Mariagiada , Spatola Daniele , Todaro Simona , Caldareri Francesco , Parente Fabrizio , Severini Alessandro , Sulli Attilio 
Published: June 2024

AbstractThe northwestern region of the Sicily Channel hosts a great number of morphological highs, the widest of which is the Adventure Plateau that is part of the Sicilian Maghrebian Fold and Thrust Belt system, formed since the Neogene. The Adventure Plateau was shaped in the Early Pliocene by an extensional phase that produced high-angle normal faults mostly WNW-ESE to N-S oriented. Through these faults, magmatic fluids ascended and produced widespread volcanic manifestations often associated to fluid flow processes. The interpretation of multibeam echosounder, seismic reflection (sparker, airgun) and well-log data allow us to identify several features related to the presence of fluids in the study area. The morpho-structural analysis showed a NW–SE oriented fault system and a string of pockmarks that follow the same trend. A detailed well-log analysis confirmed the presence of oil traces, at a depth of ~ 250 m, and gas (i.e., CO2) at a depth of ~ 450 m. The seismo-stratigraphic analysis highlighted seismic signals located below the pockmarks, (e.g. seismic chimneys, bright spots) which suggest the presence of fluids that would rise to a few meters’ depth. Based on the observations, two sources and two corresponding rising mechanisms have been identified. Morphometric analysis of pockmarks has been performed to delineate their possible interaction with the bottom currents. A fluids pathway model has been reconstructed, revealing the source of fluids emissions at depth in the Adventure Plateau, and providing new insights into the identification of fluid leakage pathways.
Experimental bifurcation analysis of a clamped beam with designed mechanical nonlinearity
Authors: Hayashi Seigan , Gutschmidt Stefanie , Murray Rua , Krauskopf Bernd 
Published: June 2024

AbstractWe use control-based continuation (CBC) to perform an experimental bifurcation study of a periodically forced dual-beam. The nonlinearity is of geometric nature, provided by a thin, clamped beam. The overall system exhibits hysteresis and bistability in its open-loop frequency response due to a hardening, Duffing-like nonlinear stiffness, which can be designed or adjusted by choosing the properties of the thin beam. We employ local stabilising feedback control to implement CBC and track stable periodic solutions past the fold points. Thus obtained continuous solution branches are used to generate the solution surface over the plane of excitation amplitude and frequency. This surface features two curves of fold bifurcations that meet at a cusp point, and they delimit the experimentally observed bistability range of this nonlinear beam.
Students’ Holistic Reading of Socio-Scientific Texts on Climate Change in a ChatGPT Scenario
Authors: Cheung Kason Ka Ching , Pun Jack K. H. , Li Wangyin 
Published: June 2024

AbstractChatGPT becomes a prominent tool for students’ learning of science when students read its scientific texts. Students read to learn about climate change misinformation using ChatGPT, while they develop critical awareness of the content, linguistic features as well as nature of AI and science to comprehend these texts. In this exploratory study, we investigated students’ reading performance in comprehending two ChatGPT-generated socio-scientific texts, with one focusing on cognitive-epistemic aspects of climate science and another one focusing on social-institutional aspects of climate science. We theorized such reading of ChatGPT-generated outputs as encompassing the content-interpretation, genre-reasoning and epistemic-evaluation domains. Combining Rasch partial-credit model and qualitative analysis, we explored and investigated how a total of 117 junior secondary students (grades 8 to 9) read such texts. Moreover, we also examined how 55 students’ holistic reading of socio-scientific texts on climate change in a ChatGPT scenario changes after a reading-science intervention. Our findings indicate that the content-interpretation was the easiest while the epistemic-evaluation domains were the most difficult. Interestingly, after the reading-science intervention, many students developed their tentative view on nature of science when they evaluated ChatGPT’s claims; while a small increase in number of students discussed reliability and non-epistemic nature of AI when they evaluated ChatGPT’s claims in relation to climate change. The findings also drive a pedagogical model that improves students’ holistic reading of socio-scientific texts generated by ChatGPT.
Einschlafen mit einem Computerspiel?
Authors: Schlarb Angelika A. , Landwehr Janna , Schneider Barbara , Prehn-Kristensen Alexander , Quante Mirja 
Published: June 2024

Zusammenfassung
Hintergrund
Mittlerweile gibt es eine zunehmende Anzahl an Apps und digitalen Spielen mit dem mehr oder weniger expliziten Ziel der Gesundheitsförderung. Eines der häufig gesuchten Themen für Health-Apps ist Schlaf. Diese werden meist im Rahmen des abendlichen Zu-Bett-Geh-Rituals oder als Einschlafhilfe eingesetzt. Die Bewertung solcher Apps oder Spiele aus schlafspezifischer Perspektive wurde bislang jedoch wenig berücksichtigt. Daher hat diese Arbeit zum Ziel, einen Kriterienkatalog zur Bewertung für Expert*innen zu entwickeln und diesen in einer ersten Testphase zu erproben.

Methode
Mittels einer umfangreichen Literaturrecherche zum Thema Game-Kriterien sowie unter Hinzunahme ähnlicher Vorarbeiten wurde in einem mehrstufigen Prozess mit einem interdisziplinären Expertenteam ein Kriterienkatalog mit Fokus auf schlaf- und entspannungsbezogene Aspekte entwickelt. Dieser wurde in einer Pilotphase getestet.

Ergebnisse
Es zeigte sich, dass für „serious games“ bestehende Kriterienvorschläge zwar einige relevante Themenbereiche abdecken, diese jedoch bei einer Anwendung zur Schlafförderung durch ihre Ausrichtung aversive Effekte erwarten lassen. Neben einer zwingend erforderlichen Adaptation der Kriterien auf die Thematik Einschlafen bzw. Entspannung sind diese zudem um weitere Kriterien für Apps der Gesundheitsförderung zu erweitern. Diese Änderungen bzw. Adaptationen sind in der vorliegenden Arbeit erfolgt.
In der Pilotphase zeigten sich die vom interdisziplinären Team entwickelten Kriterien als weitestgehend sinnvoll und adäquat für die Thematik Schlaf bzw. Entspannung.

Diskussion
Neue Apps und Games hinsichtlich der Thematik Schlaf sollten unreflektiert weder genutzt noch von Fachpersonen empfohlen werden. Bereits bei der Erstellung einer solchen Anwendung ist dringend der Einbezug eines interdisziplinären Teams anzuraten. Der erarbeitete Kriterienkatalog kann in Zukunft Fachpersonal dabei unterstützen, schlaf- oder entspannungsbezogene Apps und Spiele zu bewerten und einzuordnen.