bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost‐Effectiveness of Paclitaxel‐Coated Balloon Angioplasty in Patients With Drug‐Eluting Stent Restenosis
Authors: Dorenkamp Marc , Boldt Julia , Leber Alexander W. , Sohns Christian , Roser Mattias , Boldt Leif‐Hendrik , Haverkamp Wilhelm , Bonaventura Klaus 
Published: April 2013

AbstractBackgroundThe economic impact of drug‐eluting stent (DES) in‐stent restenosis (ISR) is substantial, highlighting the need for cost‐effective treatment strategies.HypothesisCompared to plain old balloon angioplasty (POBA) or repeat DES implantation, drug‐coated balloon (DCB) angioplasty is a cost‐effective therapy for DES‐ISR.MethodsA Markov state‐transition model was used to compare DCB angioplasty with POBA and repeat DES implantation. Model input parameters were obtained from the literature, and the cost analysis was conducted from a German healthcare payer's perspective. Extensive sensitivity analyses were performed.ResultsInitial procedure costs amounted to €3488 for DCB angioplasty and to €2782 for POBA. Over a 6‐month time horizon, the DCB strategy was less costly (€4028 vs €4169) and more effective in terms of life‐years (LYs) gained (0.497 versus 0.489) than POBA. The DES strategy incurred initial costs of €3167 and resulted in 0.494 LYs gained, at total costs of €4101 after a 6‐month follow‐up. Thus, DCB angioplasty was the least costly and most effective strategy. Base‐case results were influenced mostly by initial procedure costs, target lesion revascularization rates, and the costs of dual antiplatelet therapy.ConclusionsDCB angioplasty is a cost‐effective treatment option for coronary DES‐ISR. The higher initial costs of the DCB strategy compared to POBA or repeat DES implantation are offset by later cost savings.
Detection and identification of 2‐nitro‐morphine and 2‐nitro‐morphine‐6‐glucuronide in nitrite adulterated urine specimens containing morphine and its glucuronides
Authors: Luong Susan , Fu Shanlin 
Published: April 2013

In vitro urine adulteration is a well‐documented practice adopted by individuals aiming to evade detection of drug use, when required to undergo mandatory sports and workplace drug testing. Potassium nitrite is an effective urine adulterant due to its oxidizing potential, and has been shown to mask the presence of many drugs of abuse. However, limited research has been conducted to understand its mechanism of action, and to explore the possibility of the drugs undergoing direct oxidation to form stable reaction products.In this study, opiates including morphine, codeine, morphine‐3‐glucuronide and morphine‐6‐glucuronide were exposed to potassium nitrite in water and urine to mimic the process of nitrite adulteration. It was found that two stable reaction products were detected by liquid chromatography‐mass spectrometry (LC‐MS) when morphine and morphine‐6‐glucuronide were exposed to nitrite. Isolation and elucidation using spectrometric and spectroscopic techniques revealed that they were 2‐nitro‐morphine and 2‐nitro‐morphine‐6‐glucuronide, respectively. These reaction products were also formed when an authentic morphine‐positive urine specimen was fortified with nitrite. 2‐Nitro‐morphine was found to be stable enough to undergo the enzymatic hydrolysis procedure and also detectable by gas chromatography‐mass spectrometry (GC‐MS) after forming a trimethylsilyl derivative. On the contrary, morphine‐3‐glucuronide did not appear to be chemically manipulated when exposed to potassium nitrite in urine.These reaction products are not endogenously produced, are relatively stable and can be monitored with both LC‐MS and GC‐MS confirmatory techniques. As a result, these findings have revealed the possibility for the use of 2‐nitro‐morphine and 2‐nitro‐morphine‐6‐glucuronide as markers for the indirect monitoring of morphine and morphine‐6‐glucuronide in urine specimens adulterated with nitrite. Copyright © 2013 John Wiley & Sons, Ltd.
A method for compensating customer voltage drops due to nighttime simultaneous charging of evs utilizing reactive power injection from battery chargers
Authors: Noda Taku , Kabasawa Yuichiro , Fukushima Kentaro , Nemoto Koshichi , Uemura Satoshi 
Published: April 2013

AbstractWhen we consider global warming, the reduction of CO2 emissions is one of the most important issues which require urgent solutions. One option is to integrate low‐CO2‐emission generators to the grid as much as possible. Another option is to replace ineﬃcient vehicles based on internal‐combustion engines with electric ones (EVs). Due to the latter, we can easily predict that most consumers will charge EVs' batteries during nighttime. Thus, excessive voltage drops due to nighttime simultaneous charging are expected to be a possible future problem. This paper proposes a method for compensating the voltage drops by injecting reactive power from EV battery chargers. © 2013 Wiley Periodicals, Inc. Electr Eng Jpn, 184(1): 19–29, 2013; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.22390
Biodiesel from grease interceptor to gas tank
Authors: Ragauskas Alyse Mary E. , Pu Yunqiao , Ragauskas Art J. 
Published: April 2013

AbstractThe need for sustainable biofuels has initiated a global search for innovative technologies that can sustainably convert nonfood bioresources to liquid transportation fuels. While 2nd generation cellulosic ethanol has begun to address this challenge, other resources including yellow and brown grease are rapidly evolving commercial opportunities that are addressing regional biodiesel needs. This review examines the technical and environmental factors driving the collection of trap FOG (Fats, Oils, and Greases), its chemical composition and technologies currently available and future developments that facilitate the conversion of FOG into biodiesel.
Distribution of rotavirus G and P genotypes approximately two years following the introduction of rotavirus vaccines in South Korea
Authors: Shim Jung Ok , Thai Than Van , Ryoo Eell , Lim Inseok , Yoon Yoosik , Kim Kijeong , Chung Sang‐In , Kim Wonyong 
Published: April 2013

AbstractGenotyping of human rotaviruses was performed on 299 (40.1%) rotavirus‐positive samples obtained from 745 children with acute diarrhea in three provinces in South Korea between March 2008 and February 2010, approximately 2 years following the introduction of the RotaTeq (September 2007) and Rotarix (July 2008). The most prevalent G genotypes were G1 (51.5%), followed by G3 (24.0%), G4 (15.4%), G9 (6.4%), and G2 (4.7%). The predominant types of P genotypes were P[8] (72.6%), followed by P[6] (19.1%) and P[4] (6.0%). The phylogenetic analyses of the VP7 genes of G9 strains revealed they were highly identical and belonged in lineage III. This study highlights the consistency of the predominant G1 genotype and slightly higher predominance of the identical G9 strains over the G2 genotype. J. Med. Virol. 85:1307–1312, 2013. © 2013 Wiley Periodicals, Inc.
Intraarticular injection of synovial stem cells promotes meniscal regeneration in a rabbit massive meniscal defect model
Authors: Hatsushika Daisuke , Muneta Takeshi , Horie Masafumi , Koga Hideyuki , Tsuji Kunikazu , Sekiya Ichiro 
Published: April 2013

ABSTRACTWe investigated whether single intraarticular injection of synovial MSCs enhanced meniscal regeneration in a rabbit massive meniscal defect model. Synovium were harvested from the knee joint of rabbits, and the colony‐forming cells were collected. Two weeks after the anterior half of the medial menisci were excised in both knees, 1 × 107 MSCs in 100 μl PBS were injected into the right knee. The MSC and control groups were compared macroscopically and histologically at 1, 3, 4, and 6 months (n = 4). Articular cartilage of the medial femoral condyle was also evaluated histologically at 6 months. Multipotentiality of the colony‐forming cells was confirmed. Injected MSCs labeled with DiI were detected and remained in the meniscal defect at 14 days. The size of meniscus in the MSC group was larger than that in the control group at 1 and 3 months. The difference of the size between the two groups was indistinct at 4 and 6 months. However, histological score was better in the MSC group than in the control group at 1, 3, 4, and 6 months. Macroscopically, the surface of the medial femoral condyle in the control group was fibrillated at 6 months, while looked close to intact in the MSC group. Histologically, defect or thinning of the articular cartilage with sclerosis of the subchondral bone was observed in the control group, contrarily articular cartilage and subchondral bone were better preserved in the MSC group. Synovial MSCs injected into the knee adhered around the meniscal defect, and promoted meniscal regeneration in rabbits. © 2013 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 31:1354–1359, 2013
Determination of neotame in non‐alcoholic beverage by capillary zone electrophoresis
Authors: Hu Falian , Xu Lina , Luan Feng , Liu Huitao , Gao Yuan 
Published: April 2013

AbstractBACKGROUNDNeotame (NEO) is a new artificial sweetener approved as a food additive in many countries. The present method for the determination of NEO in various foodstuffs is high‐performance liquid chromatography (HPLC). There are no reports on the determination of NEO in foods by capillary zone electrophoresis (CZE). Therefore a simple and rapid method to determine NEO is desired for quality control.RESULTSA CZE method combined with solid phase extraction was developed for the determination of NEO in non‐alcoholic beverage. The optimum separation conditions obtained were 20 mmol L−1 sodium borate buffer, pH 8, 25 kV applied voltage, 5 s hydrodynamic injection at 30 mbar and ultraviolet detection at 191 nm. The calibration curve showed good linearity (R2= 1.000) in the range 0.5–100 µg mL−1, and the limit of detection was 0.118 µg mL−1. The method was successfully applied to the determination of NEO in two kinds of beverage with migration time less than 5 min, relative standard deviation (n = 3) less than 2% and recoveries ranging from 90 to 95%.CONCLUSIONThe proposed CZE method has the advantages of shorter analysis time and lower cost compared with HPLC, indicating that it may be a good alternative to the HPLC method. © 2013 Society of Chemical Industry
Surface electrical stimulation in dysphagic parkinson patients: A randomized clinical trial
Authors: Baijens Laura W. J. , Speyer Renée , Passos Valéria Lima , Pilz Walmari , van der Kruis Jolien , Haarmans Saskia , Desjardins‐Rombouts Christel 
Published: April 2013

Objectives/HypothesisA new treatment for oropharyngeal dysphagia in Parkinson's disease was evaluated in the present study.Study DesignProspective randomized controlled trial.MethodsThe study describes the effects of surface electrical stimulation (SES) of the neck (submental region) in dysphagic Parkinson patients using different intensities of electrical current. Quasi‐random allocation was performed when assigning patients to treatment groups. Three groups consisting of dysphagic patients with idiopathic Parkinson's disease (N = 90) received daily treatment for 15 days with periods of no treatment during the weekend. All three received traditional logopedic dysphagia treatment. In addition, two groups received SES, either motor‐level or sensory‐level stimulation. A standardized measurement protocol, including fiber optic endoscopic evaluation of swallowing (FEES) and videofluoroscopy of swallowing (VFS), was performed before and after therapy. A team of experienced raters was blinded to the treatment group and to the moment of measurement. Intrarater and interrater reliability were calculated.ResultsUsing proportional odds models (POMs), some of the visuoperceptual ordinal outcome variables showed significant improvement in all groups following treatment. Following 15 days of SES of the submental region, few significant effects were found, suggesting a therapy effect of traditional logopedic dysphagia treatment without any additional influence of SES.ConclusionsOn the grounds of this study, it is concluded that further research is needed on the exact mechanism of SES and its effects on the neural pathways involved in swallowing.Level of Evidence1b. Laryngoscope, 123:E38–E44, 2013
Adherence to vitamin supplementation following adolescent bariatric surgery
Authors: Modi Avani C. , Zeller Meg H. , Xanthakos Stavra A. , Jenkins Todd M. , Inge Thomas H. 
Published: April 2013

AbstractObjective: Adolescents with extreme obesity, who have undergone bariatric surgery, must adhere to many lifestyle and nutritional recommendations, including multivitamin therapy. Little is known about multivitamin adherence following adolescent bariatric surgery.Design and Methods: The present study aims to document self‐reported and electronically‐monitored adherence to multivitamins, determine convergence between self‐report and electronic monitoring adherence for multivitamins, and identify barriers to multivitamin adherence for adolescents who have undergone bariatric surgery.Results: The study used a prospective, longitudinal observational design to assess subjective (self‐reported) and objective (electronic monitors) multivitamin adherence in a cohort of 41 adolescents (Mean age = 17.1 ± 1.5; range = 13‐19) who have undergone bariatric surgery at Cincinnati Children's Hospital Medical Center. Mean adherence as derived from electronic monitoring for the entire 6‐month study period was 29.8% ± 23.9. Self‐reported adherence was significantly higher than electronically monitored adherence across both the 1 and 6‐month assessment points (z = 4.5, P < 0.000 and z = 4.0, P < 0.0001, respectively). Forgetting and difficulty swallowing multivitamins were the two primary barriers identified. While there are no established data regarding best practice for multivitamins following bariatric surgery, high rates of nonadherence to multivitamin therapy were observed in adolescents who had undergone bariatric surgery with forgetting and difficulty swallowing pills as reported barriers to adherence.Conclusion: These high rates of nonadherence to multivitamin therapy should be considered when devising treatment and family education pathways for adolescents considering weight loss surgery.
The effects of weight loss on relative bone mineral density in premenopausal women
Authors: Hamilton Kara C. , Fisher Gordon , Roy Jane L. , Gower Barbara A. , Hunter Gary R. 
Published: April 2013

AbstractObjective:This study compared BMD relative to body weight following a ∼6‐month weight loss program and a 1‐year weight maintenance phase in premenopausal women and determined whether African American (AA) and European‐American (EA) women's BMD respond similarly during weight loss.Design and Methods:Premenopausal women (n = 115, 34 ± 5 years) were evaluated in an overweight state (BMI between 27 and 30 kg/m2), following an 800 kcal/day diet/exercise program designed to reduce BMI<25 kg/m2, and 1‐year following weight loss.Results:BMD relative to body weight (Z‐scores) increased after weight loss, but decreased during the 1‐year weight maintenance phase. All 1‐year follow‐up BMD Z‐scores were increased (except L1) compared to baseline measurements (P < 0.05). These sites included the hip neck (+0.088, P = 0.014), total hip (+0.099, P = 0.001), L2 (+0.127, P = 0.013), L3 (+0.135, P = 0.014), and L4 (+0.199, P = 0.002). AAs had significantly higher absolute BMD at all sites (P < 0.05) compared to EAs, but no time by race interactions were evident during weight loss (except in L3).Conclusion:These results may indicate that weight loss is safe with regard to bone health for overweight premenopausal women.
Influence of acute sleep deprivation on cardiovascular parameters in female zucker obese and lean rats
Authors: Tenório Neuli M. , Tufik Sergio , Bergamaschi Cássia T. , Campos Ruy R. , Cintra Fátima , Alvarenga Tathiana A. , Andersen Monica L. 
Published: April 2013

AbstractObjective:There is a reciprocal relationship between sleep duration and weight gain. However, the consequences of this relationship on the cardiovascular system over an entire life span are still not fully elucidated. We examined the effect of acute sleep deprivation (SD) on baroreflex sensitivity and blood pressure in Zucker rats of different ages.Design and Methods:Female lean and obese Zucker rats at 3, 6 and 15 months of age were assigned to SD or control (CTRL) groups. After a 6 h period of the SD procedure (6 h of gentle handling) or CTRL procedure (an equivalent period without handling), the animals were anesthetized for surgical catheterization of the femoral artery and vein. To evaluate the baroreflex sensitivity index, bolus infusions of phenylephrine (bradycardia response) and sodium nitroprusside (tachycardia response) were administered.Results:Obesity resulted in dysfunctional tachycardia responses at 3 months of age. At 6 and 15 months of age, both bradycardia and tachycardia responses were significantly lower in obese animals than those in lean animals. At 15 months of age, interactions among obesity, SD and aging produced the most marked effects on the cardiovascular system (increased mean arterial pressure and heart rate and decreased baroreflex sensitivity).Conclusions:Therefore, these results suggest that there is no direct relationship between baroreflex imbalance and an increase in arterial pressure.
Independent and combined effects of eating rate and energy density on energy intake, appetite, and gut hormones
Authors: Karl J. Philip , Young Andrew J. , Rood Jennifer C. , Montain Scott J. 
Published: April 2013

AbstractObjective:Energy density (ED) and eating rate (ER) influence energy intake; their combined effects on intake and on postprandial pancreatic and gut hormone responses are undetermined. To determine the combined effects of ED and ER manipulation on voluntary food intake, subjective appetite, and postprandial pancreatic and gut hormone responses.Design and Methods:Twenty nonobese volunteers each consumed high (1.6 kcal g−1; HED) and low (1.2 kcal g−1; LED) ED breakfasts slowly (20 g min−1; SR) and quickly (80 g min−1; FR) ad libitum to satiation. Appetite, and pancreatic and gut hormone concentrations were measured periodically over 3 h. Ad libitum energy intake during the subsequent lunch was then measured.Results:Main effects of ED and ER on energy intake and a main effect of ER, but not ED, on mass of food consumed were observed, FR and HED being associated with increased intake (P < 0.05). Across all conditions, energy intake was highest during FR‐HED (P ≤ 0.01). Area under the curve (AUC) of appetite ratings was not different between meals. Main effects of ED and ER on insulin, peptide‐YY, and glucagon‐like peptide‐1 AUC (P < 0.05) were observed, FR and HED being associated with larger AUC. No effects on active or total ghrelin AUC were documented. Total energy intake over both meals was highest during the FR‐HED trial with the greatest difference between FR‐HED and SR‐LED trials (P ≤ 0.01).Conclusion:Consuming an energy dense meal quickly compounds independent effects of ER and ED on energy intake. Energy compensation at the following meal may not occur despite altered gut hormone responses.
Normal vs. high‐protein weight loss diets in men: Effects on body composition and indices of metabolic syndrome
Authors: Tang Minghua , Armstrong Cheryl L.H. , Leidy Heather J. , Campbell Wayne W. 
Published: April 2013

AbstractObjective:This study assessed the effectiveness of a prescribed weight‐loss diet with 0.8 versus 1.4 g protein·kg−1 day−1 on changes in weight, body composition, indices of metabolic syndrome, and resting energy expenditure (REE) in overweight and obese men.Design and Methods:Men were randomized to groups that consumed diets containing 750 kcal day−1 less than daily energy needs for weight maintenance with either normal protein (NP, n = 21) or higher protein (HP, n = 22) content for 12 weeks. The macronutrient distributions of the NP and HP diets were 25:60:15, and 25:50:25 percent energy from fat, carbohydrate, and protein, respectively. Assessments were made pre and post intervention. The subjects were retrospectively subgrouped into overweight and obese groups.Results and Conclusion:Both diet groups lost comparable body weight and fat. The HP group lost less lean body mass than the NP group (−1.9 ± 0.3 vs. −3.0 ± 0.4 kg). The effects of protein and BMI status on lean body mass loss were additive. The reductions in total cholesterol, HDL‐C, triacylglycerol, glucose, and insulin, along with LDL‐C, total cholesterol‐to‐HDL‐C ratio, and HOMA‐IR, were not statistically different between NP and HP. Likewise, macronutrient distributions of the diet did not affect the reductions in REE, and blood pressure. In conclusion, energy restriction effectively improves multiple clinical indicators of cardiovascular health and glucose control, and consumption of a higher‐protein diet and accomplishing weight loss when overweight versus obese help men preserve lean body mass over a short period of time.
Peroxisome proliferator‐activated receptor delta protects against obesity‐related glomerulopathy through the P38 MAPK pathway
Authors: Yan Zhencheng , Ni Yinxing , Wang Peijian , Chen Jian , He Hongbo , Sun Jing , Cao Tingbing , Chen Jing , Zhao Zhigang , Luo Zhidan , Chen Lin , Liu Daoyan , Zhu Zhiming 
Published: April 2013

AbstractObjective:Obesity is a prominent component of metabolic syndrome and a major risk factor for renal disease. The aim of this study was to explore the effect of cross‐talk between peroxisome proliferator‐activated receptor (PPAR)δ and p38 mitogen‐activated protein kinase (p38 MAPK) on obesity‐related glomerulopathy.Design and Methods:Male Wistar rats were randomly assigned to standard laboratory chow or a high‐fat diet for 32 weeks. Glomerular mesangial cells HBZY‐1 and mature differentiation 3T3‐L1 cells were cocultured and were transfected with PPARδ‐expressing vectors or treated with agonist or inhibitor of PPARδ or p38 MAPK.Results:Rats on a high‐fat diet showed typical characteristics of metabolic syndrome including obesity, dyslipidemia, insulin resistance, and hypertension. Rats on a high‐fat diet also had significant glomerular hypertrophy and extracellular matrix accumulation, which were accompanied by increased p38 MAPK phosphorylation and decreased PPARδ expression in the kidney tissue. The roles of p38 MAPK and PPARδ in a coculture system of mesangial cells and mature differentiation 3T3‐L1 cells were further explored. PPARδ suppression promoted laminin and type IV collagen secretion through p38 MAPK phosphorylation in mesangial cells, whereas PPARδ overexpression or PPARδ agonist attenuated phosphorylation of p38 MAPK and laminin and type IV collagen secretion.Conclusions:The characteristics of obesity‐related glomerulopathy, which might be partly caused by PPARδ suppression‐induced p38 MAPK activation and laminin and type IV collagen secretion was demonstrated.