bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic Correlates and Prognostic Significance of Kidney Injury in Heart Failure With Preserved Ejection Fraction
Authors: Salman Oday , Zhao Lei , Cohen Jordana B. , Dib Marie Joe , Azzo Joe David , Gan Sushrima , Richards A. Mark , Pourmussa Bianca , Doughty Rob , Javaheri Ali , Mann Douglas L. , Rietzschel Ernst , Zhao Manyun , Wang Zhaoqing , Ebert Christina , van Empel Vanessa , Kammerhoff Karl , Maranville Joseph , Gogain Joseph , Dennis Jaclyn , Schafer Peter H. , Seiffert Dietmar , Gordon David A. , Ramirez‐Valle Francisco , Cappola Thomas P. , Chirinos Julio A. 
Published: August 2024

Background
Kidney disease is common in heart failure with preserved ejection fraction (HFpEF). However, the biologic correlates and prognostic significance of kidney injury (KI), in HFpEF, beyond the estimated glomerular filtration rate (eGFR), are unclear.

Methods and Results
Using baseline plasma samples from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) trial, we measured the following KI biomarkers: cystatin‐C, fatty acid‐binding protein‐3, Beta‐2 microglobulin, neutrophil gelatinase‐associated lipocalin, and kidney‐injury molecule‐1. Factor analysis was used to extract the common variability underlying these biomarkers. We assessed the relationship between the KI‐factor score and the risk of death or HF‐related hospital admission in models adjusted for the Meta‐Analysis Global Group in Chronic Heart Failure risk score and eGFR. We also assessed the relationship between the KI factor score and ~5000 plasma proteins, followed by pathway analysis. We validated our findings among HFpEF participants in the Penn Heart Failure Study. KI was associated with the risk of death or HF‐related hospital admission independent of the Meta‐Analysis Global Group in Chronic Heart Failure risk score and eGFR. Both the risk score and eGFR were no longer associated with death or HF‐related hospital admission after adjusting for the KI factor score. KI was predominantly associated with proteins and biologic pathways related to complement activation, inflammation, fibrosis, and cholesterol homeostasis. KI was associated with 140 proteins, which reproduced across cohorts. Findings regarding biologic associations and the prognostic significance of KI were also reproduced in the validation cohort.

Conclusions
KI is associated with adverse outcomes in HFpEF independent of baseline eGFR. Patients with HFpEF and KI exhibit a plasma proteomic signature indicative of complement activation, inflammation, fibrosis, and impaired cholesterol homeostasis.
Clonal Hematopoiesis Is Associated With Long‐Term Adverse Outcomes Following Cardiac Surgery
Authors: Ninni Sandro , Vicario Rocio , Coisne Augustin , Woitrain Eloise , Tazibet Amine , Stewart Caitlin M. , Diaz Luis A. , White James Robert , Koussa Mohammed , Dubrulle Henri , Juthier Francis , Jungling Marie , Vincentelli André , Edme Jean‐Louis , Nattel Stanley , de Winther Menno , Geissmann Frederic , Dombrowicz David , Staels Bart , Montaigne David 
Published: August 2024

Background
Cardiac surgery triggers sterile innate immune responses leading to postoperative complications. Clonal hematopoiesis (CH) is associated with short‐term inflammation‐mediated outcomes after cardiac surgery. The impact of CH on long‐term postoperative outcomes remains unknown.

Methods and Results

In this cohort study, patients undergoing elective cardiac surgery were included from January 2017 to September 2019. Patients were screened for CH using a predefined gene panel of 19 genes. Recorded clinical events were all‐cause death, major adverse cardiac and cerebral events including cardiovascular death, myocardial infarction or nonscheduled coronary revascularization, stroke, and hospitalization for acute heart failure. The primary study outcome was time to a composite criterion including all‐cause mortality and major adverse cardiac and cerebral events. Among 314 genotyped patients (median age: 67 years; interquartile range 59–74 years), 139 (44%) presented with CH, based on a variant allelic frequency ≥1%. Carriers of CH had a higher proportion of patients with a history of atrial fibrillation (26% for CH versus 17% for non‐CH carriers,
P
=0.022). The most frequently mutated genes were
DNMT3A
,
TET2
, and
ASXL1
. After a median follow‐up of 1203 [813–1435] days, the primary outcome occurred in 50 patients. After multivariable adjustment, CH was independently associated with a higher risk for the primary outcome (hazard ratio, 1.88 [95% CI, 1.05–3.41],
P
=0.035). Most adverse events occurred in patients carrying
TET2
variants.

Conclusions
In patients undergoing cardiac surgery, CH is frequent and associated with a 2‐fold increased long‐term risk for major adverse clinical outcomes. CH is a novel risk factor for long‐term postcardiac surgery complications and might be useful to personalize management decisions.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03376165.
Atrial Imaging and Cardiac Rhythm in Cryptogenic Embolic Stroke: The ARIES Study
Authors: Rigual Ricardo , Castrejón‐Castrejón Sergio , Fernández‐Gassó Lucía , García‐Castro Jesús , Rodríguez‐Pardo Jorge , Martínez‐Cossiani Marcel , de Celis‐Ruiz Elena , Casado‐Fernández Laura , Hervás Carlos , Alonso‐López Elisa , Alonso de Leciñana María , Díez‐Tejedor Exuperio , Pérez‐David Esther , Ruiz‐Ares Gerardo , Merino José L. , Fuentes Blanca 
Published: August 2024

Background
Unknown cardioembolic sources are frequent causes of cryptogenic stroke. We analyzed the risk of atrial fibrillation (AF) or high burden of ectopic atrial activity (HBEA) in patients with cryptogenic stroke, assessing atrial function and 1‐year outcomes.

Methods and Results

The ARIES (Atrial Imaging and Cardiac Rhythm in Cryptogenic Embolic Stroke) study is an observational study including patients with cryptogenic stroke. We analyzed the frequency of AF and HBEA (>3000 atrial ectopic beats/day or >2 bursts or atrial tachycardia between 3 beats and ≤30 seconds) in two 30‐day Holter‐ECGs, comparing advanced echocardiography signs of left atrial (LA) dysfunction according to rhythm: AF, HBEA, and normal sinus rhythm. We also evaluated 1‐year stroke recurrence and mortality. The study included 109 patients; 35 (32.1%) patients had AF, 27 (24.8%) HBEA, and 47 (43.1%) normal sinus rhythm. Compared with those with normal sinus rhythm, patients with AF presented higher 2‐dimensional and 3‐dimensional LA indexed volumes (38.8±11.2 versus 27.3±11.8 mL/m
2
, and 50.6±17.2 versus 34.0±15.4 mL/m
2
, respectively,
P
<0.001), lower 3‐dimensional LA ejection fraction (50±14.6 versus 62.7±11.8,
P
=0.001), LA reservoir strain (22.0±8.6 versus 30.4±10.5,
P
<0.001), and LA contraction strain (10.5±8.18 versus 17.1±7.5,
P
<0.001), remaining significant in multivariate analysis. Patients with HBEA showed higher LA indexed volumes and lower LA reservoir strain than patients with normal sinus rhythm only in univariate analysis. There were no differences in ischemic recurrence or mortality among the groups.

Conclusions
Patients with cryptogenic stroke showed a high incidence of AF and HBEA. AF is strongly related to LA volume, LA function, and LA reservoir and contraction strain, whereas HBEA showed milder structural changes. Advanced LA echocardiography could help patient selection for long‐term ECG monitoring in suspected cardiac sources.
Second Try's a Charm: The Impact of Financial Aid Policy on Course Retaking Behavior for Low Income Students
Authors: Sovero Veronica , Griffith Amanda L. 
Published: August 2024

Abstract
In this paper, we examine the impact of a change to federal financial aid policy that gave aided students increased access to course retaking. Prior to Fall 2011, students receiving federal financial aid could not count repeated coursework towards their full-time enrollment count, despite many universities rolling out course retaking and grade forgiveness policies for their students. We use administrative records from San Francisco State University to examine how the 2011 federal financial aid policy change affected student outcomes for Pell Grant recipients. We find that the policy change led Pell-eligible students to be 3 percentage points more likely to repeat a course in which they earned a D grade on the initial attempt (approximately a 14 percent increase). We also find evidence that Pell-eligible students were more likely to attempt and earn higher credit hours after the policy change. However, despite this finding, there is no accompanying improvement in academic standing or increase in continued enrollment after the policy change. Results suggest that the policy may have influenced Pell-eligible students to take “riskier” classes with higher failure rates in science, technology, engineering, and math and business.
Navigating Firestorms: The Imperative of Conflict-Intelligent Leadership in a Turbulent World
Authors: Coleman Peter T. 
Published: August 2024

AbstractThis article offers a novel framework for conceptualizing conflict-intelligent leadership, which builds on evidence-based practices for constructive conflict resolution but extends and enhances them with new insights and strategies gleaned from complexity science. It argues that the development of conflict intelligence (CIQ) requires a broadening of one’s orientation to conflict across four levels: from a focus on and awareness of the self (implicit beliefs, emotional reactions, and ability to self-regulate), to a focus on social dynamics (interpersonal, intergroup, and moral conflict dynamics), as well as situational dynamics (conflicts in fundamentally different contexts), and ultimately to a focus on the broader systemic forces that may determine and be determined by more entrenched conflicts. The article defines CIQ, outlines the competencies and skills conducive to increasing it at each level, and offers a set of “toolkits,” with links to relevant resources such as online assessments, “just-in-time” apps, and popular articles. The aim of this article is to offer leaders a road map; a common vision, language, and skill set for navigating our often dizzying, contentious new world.
A Translation Note on Pseudo-Seneca, Her. O. 1907
Authors: Noussia Eirene Evdokia 
Published: August 2024

Abstract
The passage from pseudo-Seneca, Hercules Oetaeus 1905-1908 describes how Hercules briefly replaced the Titan Atlas in his duties supporting the Sky. However, the poet refers to Olympus, characterizing it with an epithet that does not belong to a mountain but to the sky. In this way an equation is created between these two places, mountain and sky. What is noteworthy in the passage of pseudo-Seneca, however, is not the general use of Olympus as a synonym for the sky, but the use of a designation of the sky for Olympus that completes the image of the identification of Olympus with the sky. Such mixing of adjectives is and remains rare as evidenced by the intertextual analysis attempted in the article. Moreover, mythology also mentions that Atlas holds the heavens forever (Hesiod, Vergil). It therefore follows that verse 1907 should be translated as ‘of the starry sky’ and not ‘of starry Olympus’.
Reflections on the Role of Fairness for the Sources of International Law
Authors: Kwiecień Roman 
Published: August 2024

Abstract
The paper discusses the relationship between the sources of international law and fairness. The author addresses this issue within the framework the following main question: what is the role of fairness for the formal sources of international law? By analysing the relationship between fairness and the formal sources of international law, the author also responds to two other, substantively relevant, questions: is the typology of these sources listed in Article 38 of the Statute of the ICJ fair?; is soft law a means to fairness in the sources? The author claims that fairness is neither a material nor formal source of international law but it is a procedural value which supports the legitimacy of the making of international law. Thus, it is relevant to the formal, not material, sources of international law. The term ‘formal sources’ is used in the paper in the twofold meaning. First, as instrumentum or ‘containers’ for rules and principles (where the law can be found), and, second, as processes and forms by which rules and principles are made. The author’s proposition is that fairness is primary relevant to the latter meaning. When the international law-making processes are fair, then their results, i.e., the formal sources conceived as instrumentum or ‘containers’ are also fair, and the law may be known. Rules and principles of international law are fair when they satisfy the requirements of a fair international law-making process, in particular, certainty, transparency and authoritativeness/representativeness. That is why, fairness may be seen as a crucial criterion of the legitimacy of international law-making processes. There are close relationships between fairness, law-making, legal certainty, effectiveness of rules and principles and the rule of law. These relationships mark the place of fairness in the sources of international law. The author seeks to point out that fairness as a product of the constantly changing social and political environment, does not occur in its pure form in practice. As such, fairness is a ‘matter of degree’ in the international law-making. That is why, a realistic goal of the international legal order is neutralization of unfairness as much as possible.
Validating the O&M VISSIT: Determining Appropriate Service Intensity
Authors: Pogrund Rona L. , Darst Shannon D. , Munro Heather R. 
Published: August 2024

Introduction A national validation study on the Orientation and Mobility Visual Impairment Scale of Service Intensity of Texas ( O&M VISSIT) was conducted. Methods Fifty-two of the original 115 interested participants completed the study that used a mixed-methods research design. After finishing the O&M VISSIT for a student, participants completed a survey to determine the scale's validity and reliability. Participants were from urban, suburban, and rural areas and represented a wide range of geographic areas in the United States. Results The results of the national study demonstrate support for significance in relation to content, consequential, social, content, and construct validity, as well as support for significance in relation to internal consistency reliability. Data supporting validity included 88% of study participants who reported that the tool matched their professional judgment for determining the needs of students and recommending the type and amount of service needed. Data supporting the reliability of the tool was calculated using Cronbach's alpha, which showed how well the tool measured the needs of students. The Cronbach's alpha of the O&M VISSIT was .901, which supports significant internal consistency reliability. Discussion The results support the reliability and validity of the O&M VISSIT, as well as positive feedback related to the ease of use and prospective repeated use of the tool in the future. The tool provides a reliable and valid means for O&M specialists to determine appropriate amounts of both direct and collaborative consultation services for their students receiving O&M training. Implications for Practitioners Study participants found the O&M VISSIT to be a practical and functional tool to reflect the needs of students based on an O&M evaluation and could turn the students’ needs into recommendations for type and amount of itinerant O&M services. Practitioners can rely on the statistical validity and reliability data to justify their recommendations for O&M services as research-based decisions.
Racial Discrimination, Social Support, and Psychological Distress Among Black Pregnant Women
Authors: Carey Camilla , Xie Rui , Davis Jean W. , LaManna Jacqueline B. , Misra Dawn , Giurgescu Carmen 
Published: August 2024

Background: Black pregnant women who experience racial discrimination are at an increased risk of psychological distress. Studies have not adequately addressed if social support may moderate the association between experiences of racial discrimination and psychological distress among Black pregnant women. Objective: We sought to examine the moderating effect of social support on the association between experiences of racial discrimination and psychological distress among Black pregnant women. Methods: We report findings based on cross-sectional data collected from 599 Black pregnant women enrolled in a prospective cohort study prior to the COVID-19 pandemic. Women completed questionnaires about experiences of racial discrimination (Experiences of Discrimination), social support (MOS Social Support Survey), and psychological distress (Psychological General Wellbeing Index). Results: Women had an average age of 26 ± 5 years and gestational age at data collection of 17 ± 6 weeks. Approximately 53% of women reported ever experiencing racial discrimination in at least one situation, and 54% reported psychological distress. After adjustment for covariates, racial discrimination was associated with a 2.2-fold increase in psychological distress (odds ratio [OR] = 2.24; 95% confidence interval [CI] 1.35-3.70; P = .002). Low social support (scores below the median) was associated with a 3.8-fold higher likelihood of psychological distress (OR = 3.84, 95% CI 2.27-6.48, P < .001). Social support did not moderate the association of lifetime experiences of racial discrimination with psychological distress. Conclusions: Findings of the study contribute to evidence that lifetime experiences of racial discrimination and low levels of social support relate to psychological distress among Black pregnant women.
Oral supplementation with probiotics, potassium citrate, and magnesium in reducing crystalluria in stone formers: A phase II study
Authors: Vittori Matteo , Bove Pierluigi , Signoretti Marta , Cipriani Chiara , Gasparoli Cristiano , Antonucci Michele , Carilli Marco , Maiorino Francesco , Iacovelli Valerio , Petta Filomena , Travaglia Stefano , Panei Massimo , Russo Pierluigi , Bertolo Riccardo 
Published: August 2024

Introduction: Crystalluria is an important indicator of renal stone recurrence. Mechanisms underlying urinary stone formation are still not fully understood and raising interests has been giving to intestinal commensal bacteria for their contribute in maintaining urinary solutes equilibrium. The aim of our phase II study was to examine the administration of potassium citrate, magnesium and probiotics in order to reduce crystalluria. Materials and Methods: Since May 2021, we enrolled 23 patients candidates for ureterorenolithotripsy for calcium oxalate kidney stones with crystalluria and a normal metabolic profile. The analysis was validated by the Institution’s Ethical Committee (no. approval STS CE Lazio 1/N-823). At discharge, patients were provided with daily food supplementation for 20 days of 1 billion Lactobacillus paracasei LPC09, 1 billion Lactobacillus plantarum LP01, 1 billion Bifidobacterium breve BR03, potassium (520 mg), citrate (1400 mg), and magnesium (80 mg). Crystalluria was re-assessed at 1, 3, 6, and 12-months follow-up by polarized light microscopy. Results: After one month from the oral supplementation, no patient reported crystalluria; at 3 months, among the 20 participants available for re-evaluation, still no patient reported crystalluria. Instead, crystalluria was reported in three patients (15%) at 6 months, and in five patients (25%) at 12 months follow-up. Conclusions: The oral supplementation with Lactobacillus spp. and Bifidobacterium spp. was found able to reduce the prevalence of crystalluria in a cohort of patients with diagnosis of calcium oxalate kidney stones with crystalluria candidate to ureterorenolithotripsy.
Integrating Single-Cell RNA-Seq and Bulk RNA-Seq to Construct a Novel γδT Cell-Related Prognostic Signature for Human Papillomavirus-Infected Cervical Cancer
Authors: Wang Xiaochuan , Jin Yichao , Xu Liangheng , Tao Sizhen , Wu Yifei , Ao Chunping 
Published: August 2024

Background Gamma delta (γδ) T cells play dual roles in human tumors, with both antitumor and tumor-promoting functions. However, the role of γδT cells in HPV-infected cervical cancer is still undetermined. Therefore, we aimed to identify γδT cell-related prognostic signatures in the cervical tumor microenvironment. Methods Single-cell RNA-sequencing (scRNA-seq) data, bulk RNA-seq data, and corresponding clinical information of cervical cancer patients were obtained from the TCGA and GEO databases. The Seurat R package was used for single-cell analysis, and machine learning algorithms were used to screen and construct a γδT cell-related prognostic signature. Real-time quantitative PCR (RT-qPCR) was performed to detect the expression of prognostic signature genes. Results Single-cell analysis indicated distinct populations of γδT cells between HPV-positive (HPV+) and HPV-negative (HPV-) cervical cancers. A trajectory analysis indicated γδT cells clustered into differential clusters with the pseudotime. High-dimensional Weighted Gene Co-expression Network Analysis (hdWGCNA) identified the key γδT cell-related gene modules. Bulk RNA-seq analysis also demonstrated the heterogeneity of immune cells, and the γδT-score was positively associated with inflammatory response and negatively associated with MYC stemness. Eight γδT cell-related hub genes (GTRGs), including ITGAE, IKZF3, LSP1, NEDD9, CLEC2D, RBPJ, TRBC2, and OXNAD1, were selected and validated as a prognostic signature for cervical cancer. Conclusion We identified γδT cell-related prognostic signatures that can be considered independent factors for survival prediction in cervical cancer.
Insights into a Machine Learning-Based Palmitoylation-Related Gene Model for Predicting the Prognosis and Treatment Response of Breast Cancer Patients
Authors: Zhu Hongxia , Hu Haihong , Hao Bo , Zhan Wendi , Yan Ting , Zhang Jingdi , Wang Siyu , Hu Hongjuan , Zhang Taolan 
Published: August 2024

Background Breast cancer is a prevalent public health concern affecting numerous women globally and is associated with palmitoylation, a post-translational protein modification. Despite increasing focus on palmitoylation, its specific implications for breast cancer prognosis remain unclear. The work aimed to identify prognostic factors linked to palmitoylation in breast cancer and assess its effectiveness in predicting responses to chemotherapy and immunotherapy. Methods We utilized the “limma” package to analyze the differential expression of palmitoylation-related genes between breast cancer and normal tissues. Hub genes were identified using the “WGCNA” package. Using the least absolute shrinkage and selection operator (LASSO) Cox regression analysis, we identified a prognostic feature associated with palmitoylation and developed a prognostic nomogram with the “regplot” package. The predictive values of the model for chemotherapy and immunotherapy responses were assessed using immunophenoscore (IPS) and the “pRophetic” package. Results We identified 211 differentially expressed genes related to palmitoylation, among which 44 demonstrated prognostic potential. Subsequently, a predictive model comprising eleven palmitoylation-related genes was developed. Patients were classified into high-risk and low-risk groups based on the median risk score. The findings revealed that individuals in the high-risk group exhibited lower survival rates, while those in the low-risk group showed increased immune cell infiltration and improved responses to chemotherapy and immunotherapy. Moreover, the BC-Palmitoylation Tool website was established. Conclusion This study developed the first machine learning-based predictive model for palmitoylation-related genes and created a corresponding website, providing clinicians with a valuable tool to improve patient outcomes.