bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-Dependent Effects of UV Exposure and Xeroderma Pigmentosum Group A on DNA Damage, Repair Mechanisms, Genomic Instability, Cancer Risk, and Neurological Disorders
Authors: Danter WR 
Published: July 2024

ABSTRACTBackgroundXeroderma pigmentosum, complementation group A (XPA), is a rare genetic disorder characterized by marked sensitivity to ultraviolet (UV) radiation, leading to increased risks of skin cancer, accelerated aging, and significant neurologic disorders. XPA prominently impacts DNA repair mechanisms, specifically nucleotide excision repair (NER), which is crucial for correcting UV-induced DNA damage.MethodsThis study utilized an advanced aiHumanoids platform to simulate the disease progression in individuals with XPA from birth to age 20 years. The virtual longitudinal study assessed the impacts of moderate and severe XPA under various UV exposure scenarios. The research included 25 age-matched wild-type controls to elucidate the comparative effects of XPA on DNA damage, genomic instability, cancer risk, and neurological outcomes.ResultsUsing Wilcoxon sign rank p values and Cliff’s delta estimates of true effect size, the aiHumanoid simulations revealed significant differences in DNA repair efficiency between XPA affected and control groups, with pronounced deficits in XPA cohorts under UV exposure. Genomic instability and skin cancer risks were consistently elevated across all XPA simulations, particularly under UV stress. Neurological assessments indicated greater susceptibility to disorders in younger XPA subjects, with effects moderating somewhat with age.ConclusionThe aiHumanoid platform provided novel insights into the progression of XPA, highlighting the severe impact of UV exposure on individuals with this condition. These findings advocate for early intervention strategies and underscore the necessity for rigorous protective measures against UV radiation, especially in younger populations. This research contributes to our further understanding of XPA, potentially guiding future therapeutic developments including early stage virtual drug trials and preventive approaches personalized to individual risk profiles.
Cell State-Specific Cytoplasmic Material Properties Control Spindle Architecture and Scaling
Authors: Kletter Tobias , Muñoz Omar , Reusch Sebastian , Biswas Abin , Halavatyi Aliaksandr , Neumann Beate , Kuropka Benno , Zaburdaev Vasily , Reber Simone 
Published: July 2024

ABSTRACTMitotic spindles are dynamically intertwined with the cytoplasm they assemble in. How the physicochemical properties of the cytoplasm affect spindle architecture and size remains largely unknown. Using quantitative biochemistry in combination with adaptive feedback microscopy, we investigated mitotic cell and spindle morphology during neural differentiation of embryonic stem cells. While tubulin biochemistry and microtubule dynamics remained unchanged, spindles changed their scaling behaviour: in differentiating cells, spindles were significantly smaller than those in equally-sized undifferentiated stem cells. Integrating quantitative phase imaging, biophysical perturbations and theory, we found that as cells differentiated, their cytoplasm became more dilute. The concomitant decrease in free tubulin activated CPAP (centrosomal P4.1-associated protein) to enhance the centrosomal nucleation capacity. As a consequence, in differentiating cells, microtubule mass shifted towards spindle poles at the expense of the spindle bulk, explaining the differentiation-associated switch in spindle architecture. This study shows that cell state-specific cytoplasmic density tunes mitotic spindle architecture. Thus, we reveal physical properties of the cytoplasm as a major determinant in organelle size control.
Supply chain digitalization and sports industry performance in Chinese context: a mediated moderated model
Authors: Wang Xu , Ma Lei , Niu Qun , Zhang Yong 
Published: July 2024

PurposeIn era of industry 4.0 all the organizations are investing their resources so they can adopt the latest technologies with no exception of supply chain. Accordingly, the present study attempted to examine the influence of digitalization of supply chain and performance in context of Chinese sports industry. Additionally, it has considered the supply chain integration and time management as a mechanism along with boundary condition of supply chain resilience.Design/methodology/approachThe study followed positivism philosophy and adopted quantitative methods. The data were collected by using the questionnaire from the Chinese sport industry organizations’ professionals related to logistics and supply chain. A total 746 questionnaires were distributed and 570 of them subjected to SPSS and Smart PLS for data analysis. Hypotheses were tested using PLS-SEM through the Smart-PLS 4.FindingsThe results of the study revealed that supply chain digitalization positively influences the both internal and external supply chain integration. Moreover, supply chain planning and scheduling influenced by both internal and external supply chain integration lead by supply chain digitalization. Ultimately resulting in improved sports industry performance. However, the supply chain resilience did not found as a significant moderator.Originality/valueThe study is few of the attempts that have tested a comprehensive mechanism through which the supply chain digitalization lead towards the higher performance. Also, the study results signify that the digitization can help the organizations to accomplish superior performance specifically in sports industry.
How host-country firms’ information transparency affects MNEs’ joint venture entry mode of OFDI: evidence from Chinese listed manufacturing firms
Authors: Li Naihao , Li Zijie , Zhang Banruo , Wang Yan 
Published: July 2024

Purpose
Information transparency is an important factor in enhancing trust and promoting interfirm cooperation. By combining transaction cost theory and institutional theory, this study aims to examines whether host-country firms’ information transparency prompt multinational enterprises’ (MNEs) to choose the joint venture entry mode for outward foreign direct investment (OFDI).

Design/methodology/approach
Using Heckman two-stage estimation method, this study examines Chinese listed manufacturing firms for the period 2014–2019.

Findings
The findings indicate that the higher the information transparency of host-country firms, the higher the possibility of MNEs choosing the joint venture entry mode for OFDI. This study further finds that the positive relationship between host country firms’ information transparency and the possibility of choosing the joint venture entry mode is enhanced by institutional distance, but weakened by MNEs’ host-country experience.

Originality/value
How to choose the appropriate entry mode of OFDI in the internationalization strategy is an important issue for MNEs to consider. As the postpandemic world is characterized by increased global risks, decoupling of economies, disruption of global value chains and the retreat of globalization (Contractor and Cantwell, 2022), how to further strengthen cooperation, reduce the cost and risk of MNEs and truly realize common construction and sharing is one of the hot issues in both practice and research.
Identifying librarians’ readiness to leverage artificial intelligence for sustainable competence development and smart library services: an empirical investigation from universities’ librarians
Authors: Shahzad Khurram , Khan Shakeel Ahmad , Iqbal Abid 
Published: July 2024

Purpose
This study aims to identify the librarians’ readiness to leverage artificial intelligence for sustainable competence development and smart library services.

Design/methodology/approach
This study used a quantitative research design for addressing the objectives. The population consisted of librarians from the public and private sector universities of Pakistan. The data were analyzed by using Smart PLS software.

Findings
The analysis consisted of two major parts: first the assessment of measurement model and second the structural equation modeling analysis. A significant positive impact of AI adoption was found on the implementation smart library services. Findings revealed that behavioral intention motivated librarians to adopt AI tools in university libraries for the delivery of smart library services.

Research limitations/implications
We applied quantitative method to carry out the study while future authors may conduct a systematic literature review on the same topic for offering a broader outlook.

Practical implications
It has provided practical contributions by providing a baseline for management bodies to construct policies for the successful adoption of AI in libraries for sustainable competence development of practicing librarians and implementation of smart library services.

Social implications
The study has social implications too as AI integrated library services prove fruitful for society and digitally skilled librarians play a vital role for the promotion of reading and research culture in society.

Originality/value
To the best of the authors’ knowledge, this is the first study on librarians’ readiness to leverage artificial intelligence for the enhancement of digital literacy skills, sustainable competence development and smart library services in the context of Pakistan.
Doing business against gendered stigma: skilled female migrants in Hong Kong’s cross-border insurance business
Authors: Zhou Siyuan , Song Jing 
Published: July 2024

Purpose
This study aims to examine whether skilled female migrants can overcome gender constraints and social stigma attached to women’s service work in host societies.

Design/methodology/approach
Based on interviews with 40 women who moved from mainland China and entered Hong Kong’s cross-border insurance business, the study examines how highly educated young women negotiate gender expectations and mobilize social networks in doing business.

Findings
This study finds different strategies women used in mobilizing social networks and constructing gender identities: some relied heavily on the warm market – networks of their family, relatives and friends – in doing business and developed careers by performing dutiful daughters, considerate “nieces” and caring “sisters”; some women also relied on the warm market but their jobs were regarded as nonconventional, and they had to deal with suspicions of inappropriate and instrumental womanhood and tried to prove themselves and gain support in the warm market; some women relied mainly on the cold market – connections with strangers – and performed feminine affinity to expand client networks away from judgments of families and friends; and some other women chose to expand the cold market by cultivating a professional image among strangers.

Originality/value
The findings speak to previous research about women’s subordinate roles in migrant networks and their devalued femininity in service work by illustrating women’s diverse forms of agency in negotiating gender identities in the stratified service sectors.
The impact of digital transformation on firm performance
Authors: Zhao Xu , Li Xiwa , Li Yao , Wang Ziqi 
Published: July 2024

PurposeDigital transformation (DT) is a high-risk, long-term and systematic organizational change, which is highly dependent on the level of operation management. According to the resource-based view and innovation theory, this paper aims to examine the impact of DT on firm performance.Design/methodology/approachThis paper empirically tests the impact of DT on firm performance by selecting total factor productivity and innovation outputs as mediating variables from the perspective of process and outcomes, respectively. It uses Shanghai and Shenzhen A-share-listed companies from 2010–2021 as research samples, searching the frequency of keywords about DT in their annual reports.FindingsThe findings reveal the following. First, DT can significantly improve the performance of firms. Second, total factor productivity and innovation outputs play a mediating role between DT and firm performance. Third, the impact of DT on SMEs is more obvious than in bigger ones. However, the effect of DT on performance is more significant in SOEs than non-SOEs. Furthermore, DT positively effects labor-intensive and technology-intensive firms, but negatively effects capital-intensive firms.Originality/valueThis paper first proposes the mechanism analysis from the view of process and outcomes, by using total factor productivity and innovation outputs, which adds depth to the research on the impact of DT on firm performance. Moreover, the authors empirically examine the heterogeneity of the impact of DT on different firm sizes, firm properties and intensity of production factors.
Volatility spillover and dynamic correlation between Islamic, conventional, cryptocurrency and precious metal markets during the immediate outbreak of COVID-19 pandemic
Authors: Karim Muhammad Mahmudul , Noman Abu Hanifa Md. , Hassan M. Kabir , Khan Asif , Kawsar Najmul Haque 
Published: July 2024

Purpose
This paper aims to investigate the immediate effect of the outbreak of the COVID-19 pandemic by investigating volatility transmission and dynamic correlation between stock (conventional and Islamic) markets, bitcoin and major commodities such as gold, oil and silver at different investment horizons before and after 161 trading days of the outbreak of the COVID-19 pandemic.

Design/methodology/approach
The MGARCH-DCC and maximum overlap discrete wavelet transform -based cross-correlation were used in the estimation of the volatility spillover and continuous wavelet transform in the estimation of the time-varying volatility and correlation between the assets at different investment horizons.

Findings
The authors observed a sudden correlation breakdown following the COVID-19 shock. Oil (Bitcoin) was a major volatility transmitter before (during) COVID-19. Digital gold (Bitcoin), gold and silver became highly correlated during COVID-19. The highest co-movement between the assets was observed at medium and long-term investment horizons.

Practical implications
The study findings have a financial implication for day traders, investors and policymakers in the understanding of volatility transmission and intercorrelation in a bid to actively manage stylized and well-diversified asset portfolios.

Originality/value
This study is unique for its employment in estimating the time-varying conditional volatility of the investable assets and cross-correlations between them at different investment horizons, particularly before and after COVID-19 outbreak.
Barriers to scale: the effect of regulations on entrepreneurial strategies in a nascent industry
Authors: McArdle John F. , de Koning Alice J. , Sherifi Arlinda 
Published: July 2024

PurposeThis paper aims to discuss the effect of Canada’s regulatory framework on the strategies of entrepreneurial businesses during the first phase of legalization of the recreational cannabis industry. Decriminalization of cannabis required a host of regulatory changes at the federal, provincial and municipal levels. Each province developed legal markets independently, differentially impacting entrepreneurial strategies. This paper describes the value chain that emerged in the first phase of the nascent industry, focusing on the actions of the businesses.Design/methodology/approachThe authors develop a qualitative narrative analysis using government publications, press articles (especially from the business press) and personal communications of industry insiders speaking in public settings. The paper includes four short case studies to illustrate the emerging value chain of the nascent industry.FindingsThe study’s findings highlight the effect of regulatory frameworks on entrepreneurial strategies. We find that public policies had a significant impact on entrepreneurs and startup strategies. Inter-jurisdictional differences limited expansion into different provinces, with implications for regional economic development. Achieving public policy goals was delayed as a result of regulatory challenges that impacted industry development.Practical implicationsThe authors’ findings show enterprises may develop growth strategies that comply with regulations when participating in nascent industries, but they must cope with extra risks, capital costs and uncertainty. The analysis also illustrates the value of engaging in government-industry collaboration to improve emerging regulatory frameworks.Originality/valueThe originality of this research consists of the detailed description of the first phase of Canada’s legalized recreational cannabis industry and the insight gained into the dynamics of nascent industries.
Unveiling the nexus: unravelling the dynamics of financial inclusion, FinTech adoption and societal sustainability in Malaysia
Authors: Hiew Lee-Chea , Lam Meng-Tuck , Ho Swee-Jack 
Published: July 2024

Purpose
This study aims to examine the impact of perceived benefits-risk dynamics on financial inclusion, the factor driving fintech adoption, the mediating effects of financial inclusion on perceived benefit-risk dynamics and fintech adoption, and the societal sustainability effects of fintech adoption.

Design/methodology/approach
This study used a quantitative study with 258 respondents in Sarawak, Malaysia. PLS-SEM was used to investigate the associations.

Findings
This study suggests that only non-monetary benefits and regulatory risks significantly influence financial inclusion. In addition, financial inclusion acts as an intermediary for non-monetary benefits and regulatory risks. Besides, a direct relationship exists between financial inclusion and fintech adoption, as well as between fintech adoption and societal sustainability.

Research limitations/implications
This model explores a few benefits and risks. Also, technological and legislative changes may alter research outcomes. Besides, this study only samples Sarawak, Malaysia. Therefore, country-specific factors, including technology infrastructure, financial services accessibility and cultural variations, may affect participant responses. This study offers a novel perspective on fintech by including Valence, Public Good and Sustainable Information Society theories.

Practical implications
Financial inclusion’s non-monetary benefits must be emphasised to remove barriers and meet user requirements. Fintech firms should also work with authorities to comply with regulations and help marginalised populations by prioritising sustainability.

Social implications
Fintech growth requires innovation, consumer protection and fair competition. Fintech firms can enhance financial inclusion to address inequalities (SDG10). Governments and fintech solutions should incorporate financial and digital literacy into education (SGG4).

Originality/value
Financial inclusion, fintech adoption and societal sustainability are examined using emotional, sociological and societal sustainability aspects.
An empirical investigation of student online learning continuance intention in the post-COVID-19 pandemic era
Authors: Cocosila Mihail , Trabelsi Houda , Farrelly Glen 
Published: July 2024

Purpose
The purpose of this paper is to investigate students’ viewpoint regarding continuation of using online learning in the post-COVID-19 pandemic world. While during the pandemic years predominantly all formal learning was forced to move online, in the postpandemic environment traditional postsecondary education institutions generally resumed in-person (or face-to-face) learning. Nonetheless, it is possible that some students would like to continue using online learning after using such a system during COVID-19 restrictions. Therefore, it is important for postsecondary institutions to understand students’ views on continuing with online learning so that these institutions can better adapt their offerings to learners’ preferences.

Design/methodology/approach
This study uses a cross-sectional online survey-based approach grounded on an innovative theoretical framework blending the unified theory of acceptance and use of technology 2 into the expectation-confirmation model of information systems continuance. Data were collected from 247 students in Canada in Fall 2022 and were analyzed with partial least squares structural equation modeling techniques.

Findings
Perceptions of usefulness and of monetary benefits relative to costs together with developing positive habits regarding online learning are the most significant beliefs motivating students to want to continue with online learning. Furthermore, positive disconfirmation of initial expectations and satisfaction relying on previous use together with a favorable attitude with respect to online learning strongly influence the intention to continue with online education.

Originality/value
The study opens the door for similar research in other cultural contexts (e.g. with a different individualistic-collectivistic pattern) and for other domains that moved totally online during the COVID-19 pandemic (e.g. primary health care) to maximize people satisfaction while minimizing societal costs.
e-Waste in construction: a comprehensive bibliometric analysis and review of the literature
Authors: Kumar Vineet , Verma Deepak Kumar 
Published: July 2024

Purpose
The global construction industry faces both challenges and opportunities from electronic waste (e-waste). This study aims to present a bibliometric analysis and comprehensive literature assessment on e-waste in concrete construction materials.

Design/methodology/approach
This study studies 4,122 Scopus documents to examine garbage generation in different countries and inventive ways to integrate e-waste into construction as a sustainable strategy. This study lists famous researchers and their cooperation networks, demonstrating a robust and dynamic area with a surge in research output, notably from 2018 to 2022. Data is visually represented using VOS Viewer to show trends, patterns and study interests throughout time.

Findings
The findings imply that e-waste can improve construction materials’ mechanical characteristics and sustainability. The results are inconsistent and suggest further optimization. e-Waste into construction has garnered scientific interest for its environmental, life cycle, and economic impacts. This field has great potential for improving e-waste material use, developing sophisticated prediction models, studying environmental implications, economic analysis, policy formulation, novel construction methods, global cooperation and public awareness. This study shows that e-waste can be used in sustainable building. It stresses this area’s need for research and innovation. This lays the groundwork for using electronic trash in buildings, which promotes a circular economy and environmental sustainability.

Research limitations/implications
The findings underscore the critical role of ongoing research and innovation in leveraging e-waste for sustainable building practices. This study lays the groundwork for integrating e-waste into construction, contributing to the advancement of a circular economy and environmental sustainability.

Social implications
The social implications of integrating e-waste into construction are significant. Using e-waste not only addresses environmental concerns but also promotes social sustainability by creating new job opportunities in the recycling and construction sectors. It fosters community awareness and responsibility towards sustainable practices and waste management. Additionally, this approach can reduce construction costs, making building projects more accessible and potentially lowering housing prices.

Originality/value
This research contributes to the field by offering a bibliometric analysis and comprehensive assessment of e-waste in concrete construction materials, highlighting its global significance.