bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Molecular Background of the Differential UV Absorbance of the Human Lens in the 240–400 nm Range
Authors: Pajer Viktor , Tiboldi Ákos , Bae Narkhyun , Li Kongzhao , Kang Sung Ung , Hopp Béla , Kolozsvári Lajos , Lubec Gert , Nógrádi Antal 
Published: February 2013

AbstractThe ultraviolet (UV) absorption of various sections of the human lens was studied and compared with protein expression paralleling differential UV absorbance in anterior and posterior lenticular tissue. The UV absorbance of serial lens cryostat sections (60 μm) and that of lens capsules was determined using a Shimadzu scanning spectrophotometer, and the absorption coefficients were calculated. Two‐dimensional gel electrophoresis was performed using two pooled lenticular protein extracts (anterior and posterior sections). Protein spots were quantified and significantly different spots were identified by mass spectrometry following in‐gel digestion with trypsin and chymotrypsin. The UV‐C and UV‐B absorption of the human lens increased toward the posterior parts of the lens. The anterior and posterior lens capsules also effectively absorbed UV radiation. Levels of molecular chaperone proteins Beta‐crystallin B2 (UniProtKB ID:P43320), A3 (UniProtKB ID:P05813) and of glyceraldehyde 3‐phosphate dehydrogenase (UniProtKB ID:P04406) were significantly higher in the anterior part of the lens, whereas lens proteins Beta‐crystallin B1 (UniProtKB ID:P53674) and Alpha‐crystallin A chain (UniProtKB ID:P02489) were higher in the posterior sections. These results provide evidence that differential UV absorption in the anterior and posterior lens is accompanied by differential protein expression.
The effectiveness of five natural products against three species of harmful algae
Authors: Li Yun‐Hui , Wu Ting , Yang Wei‐Dong , Li Hong‐Ye , Liu Jie‐Sheng 
Published: February 2013

AbstractThe effects of five natural products on the growth of three harmful algae species including Chattonella marina Hara et Chihara, Alexandrium tamarense Balech and Karenia mikimotoi (Miyake & Kominami ex Oda) G. Hansen & Ø. Moestrup were observed. Four products including ε‐polylysine, betaine, stachydrine and berberine exhibited selectively inhibitory effects against the three algae. However, the other product chitosan had no obvious inhibition against the above algae. Berberine and ε‐polylysine exhibited relatively higher inhibitory capability against C. marina, and betaine had the highest inhibitory effect against A. tamarense. While only berberine could effectively inhibit the growth of K. mikimotoi with LC50, 120 at 3.1 mg/L. The fast inhibitory effect against K. mikimotoi and environmental safety of berberine suggested that it might be a potential algaecide against K. mikimotoi.
Inactivation of Retinoblastoma Protein Does Not Overcome the Requirement for Human Cytomegalovirus UL97 in Lamina Disruption and Nuclear Egress
Authors: Reim Natalia I. , Kamil Jeremy P. , Wang Depeng , Lin Alison , Sharma Mayuri , Ericsson Maria , Pesola Jean M. , Golan David E. , Coen Donald M. 
Published: February 2013

ABSTRACT

Human cytomegalovirus (HCMV) encodes one conventional protein kinase, UL97. During infection, UL97 phosphorylates the retinoblastoma tumor suppressor protein (pRb) on sites ordinarily phosphorylated by cyclin-dependent kinases (CDK), inactivating the ability of pRb to repress host genes required for cell cycle progression to S phase. UL97 is important for viral DNA synthesis in quiescent cells, but this function can be replaced by human papillomavirus type 16 E7, which targets pRb for degradation. However, viruses in which E7 replaces UL97 are still defective for virus production. UL97 is also required for efficient nuclear egress of viral nucleocapsids, which is associated with disruption of the nuclear lamina during infection, and phosphorylation of lamin A/C on serine 22, which antagonizes lamin polymerization. We investigated whether inactivation of pRb might overcome the requirement of UL97 for these roles, as pRb inactivation induces CDK1, and CDK1 phosphorylates lamin A/C on serine 22. We found that lamin A/C serine 22 phosphorylation during HCMV infection correlated with expression of UL97 and was considerably delayed in
UL97
-null mutants, even when E7 was expressed. E7 failed to restore gaps in the nuclear lamina seen in wild-type but not
UL97
-null virus infections. In electron microscopy analyses, a
UL97
-null virus expressing E7 was as impaired as a
UL97
-null mutant in cytoplasmic accumulation of viral nucleocapsids. Our results demonstrate that pRb inactivation is insufficient to restore efficient viral nuclear egress of HCMV in the absence of UL97 and instead argue further for a direct role of UL97 in this stage of the infectious cycle.
Staff perceptions of quality of care: an observational study of the NHS Staff Survey in hospitals in England
Authors: Pinder Richard J , Greaves Felix E , Aylin Paul P , Jarman Brian , Bottle Alex 
Published: February 2013

BackgroundThere is some evidence to suggest that higher job satisfaction among healthcare staff in specific settings may be linked to improved patient outcomes. This study aimed to assess the potential of staff satisfaction to be used as an indicator of institutional performance across all acute National Health Service (NHS) hospitals in England.MethodsUsing staff responses from the NHS Staff Survey 2009, and correlating these with hospital standardised mortality ratios (HSMR), correlation analyses were conducted at institutional level with further analyses of staff subgroups.ResultsOver 60 000 respondents from 147 NHS trusts were included in the analysis. There was a weak negative correlation with HSMR where staff agreed that patient care was their trust's top priority (Kendall τ = −0.22, p<0.001), and where they would be happy with the care for a friend or relative (Kendall τ = −0.30, p<0.001). These correlations were identified across clinical and non-clinical groups, with nursing staff demonstrating the most robust correlation. There was no correlation between satisfaction with the quality of care delivered by oneself and institutional HSMR.ConclusionsIn the context of the continued debate about the relationship of HSMR to hospital performance, these findings of a weak correlation between staff satisfaction and HSMR are intriguing and warrant further investigation. Such measures in the future have the advantage of being intuitive for lay and specialist audiences alike, and may be useful in facilitating patient choice. Whether higher staff satisfaction drives quality or merely reflects it remains unclear.
Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation
Authors: Fowler Daniel H. , Mossoba Miriam E. , Steinberg Seth M. , Halverson David C. , Stroncek David , Khuu Hahn M. , Hakim Frances T. , Castiello Luciano , Sabatino Marianna , Leitman Susan F. , Mariotti Jacopo , Gea-Banacloche Juan C. , Sportes Claude , Hardy Nancy M. , Hickstein Dennis D. , Pavletic Steven Z. , Rowley Scott , Goy Andre , Donato Michele , Korngold Robert , Pecora Andrew , Levine Bruce L. , June Carl H. , Gress Ronald E. , Bishop Michael R. 
Published: February 2013

Key PointsDonor T-Rapa cells were composed of Th1 and Th2 effectors with a reproducible gene expression profile. Preemptive T-Rapa donor lymphocyte infusion was safe and associated with donor engraftment without excessive GVHD.
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant
Authors: McIntosh Jenny , Lenting Peter J. , Rosales Cecilia , Lee Doyoung , Rabbanian Samira , Raj Deepak , Patel Nishil , Tuddenham Edward G. D. , Christophe Olivier D. , McVey John H. , Waddington Simon , Nienhuis Arthur W. , Gray John T. , Fagone Paolo , Mingozzi Federico , Zhou Shang-Zhen , High Katherine A. , Cancio Maria , Ng Catherine Y. C. , Zhou Junfang , Morton Christopher L. , Davidoff Andrew M. , Nathwani Amit C. 
Published: February 2013

Key Points
Novel, more potent codon-optimized human FVIII variant (codop-hFVIII-V3). Codop-hFVIII-V3 is safe and efficacious in mice and nonhuman primates, thus improving the prospects of gene therapy for hemophilia A.
Evaluation of vegetable and fish oils diets for the amelioration of diabetes side effects
Authors: Al-Amoudi Nadia Saleh , Abu Araki Huda A 
Published: February 2013

Abstract
Background
In the existing literature, the evidence regarding the effects of certain oils on the amelioration of hyperglycemia contains ambiguities and contradictions; and with regard to other oils, the quantity of existing studies is scant.

Objective
To assess the influence of sesame, garden rocket, organic olive, thyme, fenugreek, hazelnut, and cod liver oil on serum glucose, liver function, and kidney functions.

Methods
Male albino rats were injected with streptozotocin (60 mg/kg BW). The duration of the experiment was 28 days. Maximum recovery of occurred wasting attributable to diabetes was found in the sesame and cod liver groups.

Results
With respect to ameliorating and/or preventing the side effects of diabetes on liver function, this experiment showed that thyme, organic olive, cod liver, and fenugreek oils were efficacious. Turning to serum lipid profile, organic olive oil not only ameliorated but also prevented the changes of TC, HDL, LDL, and AI. Vegetable and cod liver oil diets resulted in a marked amelioration of renal dysfunction, but they were unable to prevent this side effect. Similar, oil diets were unable to mask the increase in serum glucose due to diabetes mellitus.

Conclusion
On the basis of these findings, it could be recommended that when attempting oil diet treatment for the side effects of diabetes, a blend of the various specific treatments which showed best results should be employed in order to achieve improvement with respect to all parameters; and in part, this is because a synergism between the various treatments can be expected.
Maternal depression, antidepressant use in pregnancy and Apgar
scores in infants
Authors: Jensen Hans M⊘rch , Gr⊘n Randi , Lidegaard Øjvind , Pedersen Lars Henning , Andersen Per Kragh , Kessing Lars Vedel 
Published: February 2013

BackgroundUse of antidepressants during pregnancy has been associated with a low
Apgar score in infants but a contribution from the underlying depressive
disorder might influence this association.AimsTo estimate the effects of maternal depression and use of antidepressants
during pregnancy on low Apgar scores (<7) 5min after birth.MethodRegister study on all pregnant women in Denmark from 1996 to 2006 linking
nationwide individualised data from the Medical Birth Register, the
Psychiatric Central Register and the National Prescription database.ResultsInfants exposed to antidepressants during pregnancy had an increased rate
of a low Apgar score (odds ratio (OR) = 1.72, 95% CI 1.34-2.20). The
increased rate was only found among infants exposed to selective
serotonin reuptake inhibitors (SSRIS) (OR =1.96, 95% CI 1.52-2.54), not
among those exposed to newer (OR = 0.83, 95% CI 0.40-1.74) or older
antidepressants (OR=0.53, 95% CI 0.19-1.45). Maternal depression before
or during pregnancy, without prescription of antidepressants, was not
associated with a low Apgar score (OR=0.44, 95% CI 0.11-1.74). Women who
had only used antidepressants prior to pregnancy had no increased rate of
a low Apgar score in their subsequent pregnancy, regardless of depression
status.ConclusionsUse of SSRls during pregnancy increases the risk of a low Apgar score
independently of maternal depression.
Two-photon double ionization of helium: investigating the importance of correlation in the final state
Authors: Simonsen Aleksander , Askeland Sigurd , Førre Morten 
Published: February 2013

AbstractIn this paper, we present theoretical results for the process of non-sequential two-photon double ionization of helium at the photon energy 42 eV. Our approach is based on solving the time-dependent Schrödinger equation in a B-spline based numerical framework. Information about the process is obtained by extracting the double-ionized component by means of uncorrelated final states. The total (generalized) cross section for the process is extracted, as well as differential cross sections resolved in electron energies and ejection angles. We focus on the impact the final-state correlation has on the accuracy of the cross sections.
On spectral relaxation method approach for steady von Kármán flow of a Reiner-Rivlin fluid with Joule heating, viscous dissipation and suction/injection
Authors: Motsa Sandile , Makukula Zodwa 
Published: February 2013

Abstract
In this study we use the spectral relaxation method (SRM) for the solution of the steady von Kármán flow of a Reiner-Rivlin fluid with Joule heating and viscous dissipation. The spectral relaxation method is a new Chebyshev spectral collocation based iteration method that is developed from the Gauss-Seidel idea of decoupling systems of equations. In this work, we investigate the applicability of the method in solving strongly nonlinear boundary value problems of von Kármán flow type. The SRM results are validated against previous results present in the literature and with those obtained using the bvp4c, a MATLAB inbuilt routine for solving boundary value problems. The study highlights the accuracy and efficiency of the proposed SRM method in solving highly nonlinear boundary layer type equations.
A Lennard-Jones-like perspective on first order transitions in biological helices
Authors: Oskolkov Nikolay , Bohr Jakob 
Published: February 2013

Abstract
Helical structures with Lennard-Jones self-interactions are studied for optimal conformations. For this purpose, their self-energy is analyzed for extrema with respect to the geometric parameters of the helices. It is found that Lennard-Jones helices exhibit a first order phase transition from a state with large curvature of the helical backbone to one with a small curvature. I.e. from a dense helix to an extended helix. A transition from one helical structure to another is a phenomenon known to take place in self-assembling helices formed in multicomponent solutions with cholesterol.
Diabetes-mediated changes in rat type i collagen and spermatogenesis indices
Authors: Bondarenko Larysa B. , Shayakhmetova Ganna M. , Matvienko Anatoliy V. , Kovalenko Valentina M. 
Published: February 2013

Abstract Objectives: To investigate the effects of diabetes on the reproductive system andextracellular matrix proteins of diabetic rats. Materials and Methods: Wistar albinomale rats, body weight (BW) 160-200 g, were divided into two groups: I -streptozoticin diabetes, II - normal non-diabetic animals. The content of amino acidsin rat type I collagen was determined using an amino acid analyzer. Morphologicalanalyses of gonadic structures were carried out by an optic microscope. Results: Thestudy of the effects of diabetes on type I collagen amino acid content, testis cellsmorphologic and morphometric parameters and spermatogenesis demonstrated thepresence of diabetes-mediated quantitative and qualitative changes in male ratreproductive organs, spermatogenetic epithelial cells and extracellular matrixproteins in comparison with normal. Conclusions: Observed collagen moleculeschanges could hence affect the properties and correct functioning of spermatogeneticepithelium and of other tissues of reproductive organs. They could be caused bydiabetes via deficiency of insulin which is involved in collagen synthesis regulationat different stages of this process, cytochrome P450-2E1 induction and reactiveoxygen species effects on protein biosynthesis processes.
Transversal analysis of junk food diet for a group of medical students and its association with metabolic syndrome
Authors: Niţescu Maria , Streinu-Cercel Adrian , Oţelea Marina , Furtunescu Florentina Ligia 
Published: February 2013

Abstract Objective: to evaluate the nutritional behavior of medical students regarding junkfood intake in relation with the metabolic syndrome (MS). Material and Method:
Prevalence and Risk of Dupuytrèn Disease in Patients with Diabetes Versus Non-Diabetic Patients
Authors: Kovacs Denisa , Demian Luiza , Babeş Aurel 
Published: February 2013

AbstractObjectives: The aim of the study was to calculate the prevalence rates and risk ofappearance of Dupuytrèn disease in diabetic patients with both type-1 (T1DM) andtype-2 diabetes (T2DM). Material and Method: 384 patients were analysed, ofwhich 47 had T1DM, 140 had T2DM and 197 were non-diabetic controls. Diabeticpatients were followed at the Clinical Center for Diabetes, Nutrition and MetabolicDisease of the Emergency Clinical County Hospital and Department of Dermatologyin Oradea, all of them having a diabetes duration of at least 5 years. Results and Conclusions: The risk of Dupuytrèn’s disease is over 4.5 times greater in patientswith type-2 diabetes. The risk of Dupuytrèn’s disease is 3-6 times greater in patientswith micro-vascular complications.
De l'île de Ré à l'ile d'Arros
Authors: Delalande Nicolas , Spire Alexis 
Published: February 2013

Résumé Comment expliquer que des responsables politiques puissent conduire des politiques fiscales à l’avantage des plus riches, tout en obtenant l’assentiment de la majorité de la population ? À travers l’étude de la genèse puis de la suppression du bouclier fiscal, entre 2005 et 2011, cet article montre comment ses promoteurs ont su utiliser les symboles, les récits et les statistiques pour maintenir un voile d’ignorance quant à la position sociale des bénéficiaires. D’instrument destiné à protéger les contribuables de l’impôt, ce dispositif est pourtant devenu en quelques années l’incarnation du clientélisme politique. Les symboles offrent des ressources pour la construction des problèmes publics, mais peuvent aussi devenir des stigmates lorsque la réalité se révèle trop éloignée de la fiction imaginée. Cette étude met ainsi en lumière la dimension dynamique et évolutive de la construction des problèmes publics.
Rendre visible et laisser dans l'ombre
Authors: Jouzel Jean-Noël , Dedieu François 
Published: February 2013

Résumé En s’intéressant au phénomène de la méconnaissance des effets pathogènes pesticides sur la santé des agriculteurs, les auteurs cherchent à comprendre comment les instruments de connaissance qu’utilisent les politiques publiques peuvent avoir pour conséquence paradoxale d’obscurcir la compréhension des problèmes sociaux. Ils s’appuient pour cela sur les travaux récents portant sur les dynamiques de production organisée de l’ignorance, qu’ils complètent en en soulignant les prolongements politiques et moraux. Ils mettent ainsi en évidence deux facteurs d’invisibilité sociale des maladies induites par les pesticides parmi les travailleurs agricoles : la sous-reconnaissance institutionnalisée des pathologies chroniques causées par les expositions répétées à de faibles doses de pesticides ; la sous-déclaration par les victimes des pathologies aiguës induites par les intoxications ponctuelles à hautes doses.
Repenser les identités régionales par les élargissements
Authors: Bafoil François 
Published: February 2013

Résumé L’Association des nations du Sud-Est asiatique (Asean) et l’Union européenne (UE) ont expérimenté des changements considérables en s’élargissant, dans les années 1990 et 2000. Dans les deux régions, l’intégration s’est faite au profit de pays dits « en retard de développement », souvent qualifiés de « faibles ». Néanmoins, le paradoxe de ces élargissements tient au fait que ces pays, loin d’être marginalisés, ont pu réaffirmer leur souveraineté nationale. Par ce biais, ils se sont posés à égalité de leurs nouveaux partenaires, en leur contestant toute capacité d’exercer la moindre hégémonie, notamment en arguant des principes fondateurs de chacune des unions. En reformulant les valeurs et les identités régionales, ils ont su transformer leur « faiblesse » en « force ».
Choosing wisely: The American College of Rheumatology's top 5 list of things physicians and patients should question
Authors: Yazdany Jinoos , Schmajuk Gabriela , Robbins Mark , Daikh David , Beall Ashley , Yelin Edward , Barton Jennifer , Carlson Adam , Margaretten Mary , Zell JoAnn , Gensler Lianne S. , Kelly Victoria , Saag Kenneth , King Charles ,   The American College of Rheumatology Core Membership Group
Published: February 2013

AbstractObjectiveWe sought to develop a list of 5 tests, treatments, or services commonly used in rheumatology practice whose necessity or value should be questioned and discussed by physicians and patients.MethodsWe used a multistage process combining consensus methodology and literature reviews to arrive at the American College of Rheumatology's (ACR) Top 5 list. Rheumatologists from diverse practice settings generated items using the Delphi method. Items with high content agreement and perceived high prevalence advanced to a survey of ACR members, who comprise >90% of the US rheumatology workforce. To increase the response rate, a nested random sample of 390 rheumatologists received more intensive survey followup. The samples were combined and weighting procedures were applied to ensure generalizability. Items with high ratings underwent literature review. Final items were then selected and formulated by the task force.ResultsOne hundred five unique items were proposed and narrowed down to 22 items during the Delphi rounds. A total of 1,052 rheumatologists (17% of those contacted) participated in the member‐wide survey, whereas 33% of those in the nested random sample participated; respondent characteristics were similar in both samples. Based on survey results and available scientific evidence, 5 items (relating to antinuclear antibodies, Lyme disease, magnetic resonance imaging, bone absorptiometry, and biologic therapy for rheumatoid arthritis) were selected for inclusion.ConclusionThe ACR Top 5 list is intended to promote discussions between physicians and patients about health care practices in rheumatology whose use should be questioned and to assist rheumatologists in providing high‐value care.
A new probe of black holes and their environment: Luminous flares from tidally disrupted stars
Authors: Komossa S. 
Published: February 2013

AbstractThe luminous accretion flares from tidally disrupted stars represent a powerful probe of the presence of supermassive black holes (SMBHs) in otherwise non-active galaxies, of accretion physics and BH spin, of jet formation, and relativistic effects. Further, the reprocessing of the continuum radiation of the flare into IR, optical and UV emission lines provides us with multiple new diagnostics of the properties of any gaseous material in the vicinity of the SMBH and in the host galaxy itself. While first events were discovered in the course of the ROSAT all-sky survey in X-rays, the last few years have seen the detection of several more flares, including in the UV, optical and radio band and via their emission-line “echoes”. A wealth of applications will become feasible in upcoming years, once flares are detected in large numbers in current and future sky surveys.
Contribution of Advection Process in SOC Model Causing the Appearance of Lognormal Distribution in Emission
Authors: Kunjaya Chatief , Mahasena Putra , Vierdayanti Kiki , Herlie Stefani 
Published: February 2013

AbstractEmission variability from Black Hole objects like Seyfert Galaxies, Quasars etc. shows a irregular variation with various amplitude and time scale. Further analysis of the emission shows the appearance of the lognormal distribution. Such distribution cannot be explained by conventional Self Organized Criticality (SOC) Model. In this paper a modified SOC model with cellular automaton mechanism combined with advection process is introduced. Simulation shows that lognormal distribution can be resulted, while the other characteristics of PSD and structure function of the original SOC model can be maintained. Incorporation of the advection process is the key factor for the appearance of lognormal distribution.