bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclamen libanoticum is a Novel Bioresource for Green Silver Nanoparticles with Antibacterial and Antioxidant Capabilities
Authors: Hachem Zeinab , Kashmar Rayan , Abdallah Alaa M. , Awad Ramadan , Khalil Mahmoud I. 
Published: July 2024

Background:
It has become essential to look into alternatives that effectively stop
bacterial infections due to the exponential rise in antibiotic resistance. The field of nanotechnology
has made significant strides in development by surmounting obstacles that have impeded
success and advancement in other fields. Nanoparticles (NPs) are the key component in the burgeoning
field of nanotechnology.

Objective:
Cyclamen libanoticum leaf extract (CLE) was used as a reducing and capping agent,
with silver nitrate (AgNO3) solution as a precursor for synthesizing silver nanoparticles (CLEAgNPs).
This study aimed to generate green silver nanoparticles (AgNPs) and assess their antioxidant
and antibacterial capacities.

Methods:
CLE-AgNPs were characterized utilizing UV–vis spectrometry, X-ray diffraction
(XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS),
Fourier transform infrared spectroscopy (FTIR), and photoluminescence (PL). Using the radical
scavenging assay 2,2-diphenyl-1-picrylhydrazyl (DPPH), the antioxidant activity of CLEAgNPs
was evaluated. Several assays were employed to examine the antibacterial effect of
CLE-AgNPs against various gram-positive and negative bacteria.

Results:
Upon analysis, the synthesis revealed 17 nm face-centered cubic CLE-AgNPs (λmax=
431 nm). CLE-AgNPs manifested noticeable antioxidant activity and prominent inhibitory effects
on the tested bacteria. The minimum inhibitory concentration (MIC) of the CLE-AgNPs
was 31.25 μg/mL for the eight bacterial species. Besides, the results revealed that CLE-AgNPs
effectively suppressed the development of bacterial biofilms and could eradicate them.

Conclusion:
The present investigation introduced Cyclamen libanoticum as a novel bioresource
into green chemistry to produce AgNPs with antibacterial and antioxidant capabilities.
Silicon Carbide-based Materials from Rice Husk
Authors: Cong Qianmin , Zhu Xingxing , Ban Zhangjie , Li Junzhe , Cai Zhengyu , Pei Lizhai 
Published: July 2024

Background:
Rice husk is an important agricultural waste that contains organic mass
and bio-silica. Although some rice husks have been used as fuel, animal food, filler for wine
fermentation, and fertilizer, the majority are discarded as agricultural waste, which does great
harm to the environment. The conversion of rice husk to silicon carbide (SiC)-based materials
satisfies the demand for the reutilization of solid wastes.

Methods:
The article reviews recent progress and patents on the SiC-based materials from rice
husk. The possible development directions of the SiC-based materials from rice husks are also
analyzed.

Results:
SiC materials with different morphologies, including microscale and nanoscale particles,
nanoscale whiskers, and nanowires, can be prepared by high-temperature carbothermal
reduction reaction from rice husk at the temperature of 1200-1800°C, reaction time of 0.5-8 h,
respectively. SiC-based composites, including SiC nanowires/C, Al/SiC, SiC/Si3N4, and
SiC/Al2O3, can be obtained using rice husk as main source materials at 800-1800°C. SiC-based
materials exhibit great application potential in the fields of absorbents, optical devices, mechanical
products, photocatalysts, semiconductors, and Li-ion batteries.

Conclusion:
The low cost of preparing SiC-based materials from rice husk, combining them
with different compositions, and exploring new applications are important research directions in
the future.
Rank Matrix Approach for Endometriosis: Integrating Data and Constructing Diagnostic Models
Authors: Xie Ranze , Hong Deqing , Yuan Jiaqi , Xu Peng , Liu Wenbin , Ye Zheng 
Published: July 2024

Background:
Endometriosis is a debilitating gynecological disorder characterized by
chronic pain, infertility, and the growth of endometrial tissue outside the uterus. Accurate and early
detection of this condition is crucial for effective management and treatment.

Methods:
We developed a gene rank matrix-based model to integrate endometriosis cohorts across
multiple platforms. After removing batch effects, we identified 83 genes associated with endometriosis
and further refined a diagnostic model using 11 of these genes. The model was trained on
two platforms and validated on two others using SVM, Random Forest, Logistic Regression, and
gradient-boosting machine learning algorithms.

Results:
The integration via the gene rank matrix effectively mitigated batch effects. Utilizing a
gradient boosting classifier with a subset of 11 genes, the model demonstrated commendable diagnostic
efficacy, achieving an Area Under the Curve (AUC) of 0.77, an accuracy of 0.72, and an F1
score of 0.72 for the training dataset. When subjected to validation, the model maintained its performance,
yielding an AUC of 0.769, an accuracy of 0.719, and an F1 score of 0.732. These 11
genes were found to be associated with immunosuppression.

Conclusion:
Our approach to integrating gene rank matrices effectively consolidates endometriosis
data across diverse platforms. The diagnostic model, harnessing the predictive power of 11 specific
genes, surpasses alternative models, thereby offering promising prospects for aiding clinical diagnosis
of endometriosis. Further validation is imperative to elucidate the functional significance of
these 11 genes. Our study underscores the potential of data integration coupled with machine learning
techniques in advancing the diagnosis of intricate diseases, such as endometriosis.
Potential of Natural Products as Therapeutic Agents for Inflammatory Diseases
Authors: Aundhia Chintan , Parmar Ghanshyam , Talele Chitrali , Sadhu Piyushkumar , Sen Ashim Kumar , Rana Pramojeeta 
Published: July 2024

:
Inflammation is a complex biological response that plays a pivotal role in various pathological
conditions, including inflammatory diseases. The search for effective therapeutic agents has
led researchers to explore natural products due to their diverse chemical composition and potential
therapeutic benefits. This review comprehensively examines the current state of research on natural
products as potential therapeutic agents for inflammatory diseases. The article discusses the antiinflammatory
properties of various natural compounds, their mechanisms of action, and their potential
applications in managing inflammatory disorders. Additionally, formulation and delivery
systems, challenges and future prospects in this field are also highlighted.
Release Kinetics of Sulfentrazone from Chitosan Clay Sulfentrazone Nanocomposite
Authors: Mishra Praveen Kumar , Usmani Ghayas Ahmad , Goswami Ajaygiri , Mondal Achintya 
Published: July 2024

Introduction:
With a rational objective to reduce groundwater contamination from pesticides
and thereby reducing ecotoxicological effect of pesticide, present research programme was
carried out. Sulfentrazone is a well-known effective pesticide that is used for soybean crops. But at
the same time, sulfentrazone is known for its high leaching potential through soil and could lead to
ground water contamination.

Methods:
So we have synthesized a novel chitosan clay nanocomposites of sulfentrazone at three
different concertations of sulfentrazone, 37.64%, 52.44% and 59.85% and its release pattern was
studied at three different buffer systems like pH 2, pH 4 and pH 6. Release pattern of Sulfentrazone
has been quantified by using High Performance Liquid Chromatography (HPLC) technique. Various
mathematical tools have been applied to understand the release kinetics of chitosan clay sulfentrazone
nanocomposites.

Results:
Correlation coefficient (R2) of many models has been plotted and the Huguchi model was
found to be the most suitable for these nanocomposites. The salient finding of this study is that the
release rates of sulfentrazone at pH 4 is 68.39%, 42.62% and 37.75% after 8 hours at three different
loading. This release pattern is higher than the release pattern at pH 6 and pH 2.

Conclusion:
Based on these release data, it is very clear that chitosan clay sulfentrazone nanocomposite
can control the release of sulfentrazone at regular soil pH conditions, which is pH 6.
Evaluation of Anti-microbial Activity of Novel Polyherbal Lozenges for the Management of Infection
Authors: Nagpal Kajal , Handa Uditi , Sharma Anjali , Arora Deepshi , Jan Fatimah 
Published: July 2024

Background:
The use of commercial tinctures for the design of a formulation with improved anti-microbial activity in a polyherbal lozenge dosage form has not been described.

Objective:
This study aimed to develop and evaluate the antimicrobial activity of a novel polyherbal
lozenge formulation containing Ashwagandha, Neem, and Tulsi tinctures in a single-dose
administration. According to previous studies, each of these herbs could be used in herbal medicine
to provide relief from infection owing to their antimicrobial activity, besides other properties,
such as anticancer, antidiabetic, etc.

Methods:
The lozenges were prepared using the molding method using three concentrations (1,
3, and 5 % w/w) of commercialized herbal tinctures. Then, they were studied using different
assays, including those designed to evaluate physical properties, stability, and antimicrobial activity.

Results:
B4, containing 5% w/w of each tincture, showed the highest antimicrobial activity compared
with the other batches. This batch exhibited the highest value of bacterial inhibition (17.1
± 0.07 mm), according to the agar well diffusion method, including Escherichia coli as a test
microorganism. Hence, B4 was chosen for additional analyses, including physical properties and
stability tests. The results followed Indian Pharmacopeia standards and ICH guidelines, respectively.
The formulation was stable after 2 weeks, and no significant changes were observed in
its physical properties or antimicrobial activity.

Conclusion:
This study shows that polyherbal lozenges have anti-microbial activity, with a disintegration
period of 3.86 ± 0.07 minutes in the B4 batch.
MicroRNA Biomarkers on Day of Injury Among Patients with Post Concussive Symptoms at 28-Days: A Prospective Cohort Study
Authors: Mitra Biswadev , Major Brendan , Reyes Jonathan , Surendran Nanda , Bain Jesse , Giesler Lauren P. , O'Brien William T. , Sorich Edmond , Willmott Catherine , Shultz Sandy R. , O'Brien Terence J. , Rosenfeld Jeffrey V. , McDonald Stuart J. 
Published: July 2024

Background:
After mild traumatic brain injury (mTBI), some patients experience symptoms that persist for weeks to months. Recovery from mTBI is primarily assessed using self-reported symptom questionnaires. Blood biomarkers, including microRNA species, have shown promise to assist diagnosis of mTBI, however, little is known about how blood microRNA measures might predict symptom recovery.

Objective:
The aim of this study was to investigate the variances in plasma microRNAs on the day of injury between individuals with mTBI who report post-concussive symptoms at the 28-day mark and those who do not.

Methods:
Patients who presented to an adult, tertiary referral hospital emergency department on the day of the injury and were diagnosed with isolated mTBI (n=35) were followed up for 28 days. Venous blood samples were collected and symptom severity was assessed using the River-mead Post-Concussion Symptom Questionnaire (RPQ) on the day of injury and at 28 days. Patients who reported ongoing symptoms of total RPQ score ≥10 or at least one symptom severity ≥2, were compared to those with lesser symptom severity or symptom resolution.

Results:
There were 9 (25.7%; 95%CI: 12.5-43.3) patients who reported persistent symptoms. Day of injury plasma miR-223-3p levels were significantly higher in individuals with ongoing symptoms compared to those without, however, no such differences were observed for miRs 142-3p, 423-3p, 32-5p, 144-3p, and let-7f-5p.

Conclusion:
Acute plasma miR-223-3p levels appear to detect patients who later have persistent symptoms after mTBI. The results demonstrate the potential utility for such biomarkers to assist in decisions towards early referral for therapy after mTBI.
Glioblastoma Multiforme miRNA based Comprehensive Study to Validate Phytochemicals for Effective Treatment against Deadly Tumour through In Silico Evaluation
Authors: Khan Roji Begam , Tiwari Shikha , Jarkharya Aryan , Tiwari Archana , Chowdhary Rashmi , Shrivastava Adesh 
Published: July 2024

Background:
Glioblastoma Multiforme (GBM) is a prevalent and deadly type of pri-mary astrocytoma, constituting over 60% of adult brain tumors, and has a poor prognosis, with a high relapse rate within 7 months of diagnosis. Despite surgical, radiotherapy, and chemotherapy treatments, GBM remains challenging due to resistance. MicroRNA (miRNAs) control gene ex-pression at transcriptional and post-transcriptional levels by targeting their messenger RNA (mRNA), and also contribute to the development of various neoplasms, including GBM.

Methods:
The present study focuses on exploring the miRNAs-based pathogenesis of GBM and evaluating most potential plant-based therapeutic agents with in silico analysis. Gene chips were retrieved from the Gene Expression Omnibus (GEO) database, followed by the Robust- Rank-Aggereg algorithm to determine the Differentially Expressed miRNAs (DEMs). The predicted targets were intersected with the GBM-associated genes, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the overlapping genes was performed. At the same time, five phytochemicals were selected for the Connectivity map (CMap), and the most efficient ones were those that had undergone molecular docking analysis to obtain the potential therapeutic agents.

Results:
The hsa-miR-10b, hsa-miR-21, and hsa-miR-15b were obtained, and eight genes were found to be associated with glioma pathways; VSIG4, PROCR, PLAT, and ITGB2 were upregulated while, CAMK2B, PDE1A, GABRA1, and KCNJ6 were downregulated. The drugs Resveratrol and Quercetin were identified as the most prominent drugs.

Conclusion:
These miRNAs-based drugs can be used as a curative agent for the treatment of GBM. However, in vivo, experimental data, and clinical trials are necessary to provide an alter-native to conventional GBM cancer chemotherapy.
Targeting to Overexpressed Receptor in Colon Cancer: A Review
Authors: Sharma Tarun , Islam Md. Moidul , Lunawat Akshay Kumar , Raikwar Sarjana 
Published: July 2024

:
Colon cancer is a major global health concern characterized by complex interactions
of genetic, environmental, and lifestyle factors. The "hallmarks of cancer" encompass
various distinctions between cancerous and normal tissues, including vascular characteristics,
making it a possible target for medication administration with specificity. The tumor microenvironment
in colon cancer is a dynamic ecosystem comprising various cell types like cancer-
associated fibroblasts, immune cells, and endothelial cells, influencing tumor progression
and response to therapy. Various overexpressed receptors in colon cancer, like G-proteincoupled
receptors (GPCRs), integrins, folate receptors, transferrin receptors, epidermal
growth factor receptors (EGFRs), and CD-44 receptors, offer opportunities for targeted drug
delivery. These receptors play vital roles in cancer cell growth, proliferation, and metastasis,
making them important targets for therapeutic intervention.
Functionalised Ligand-Based Nanomaterial Drug Targeting Approaches for Colorectal Cancer Therapy
Authors: Dixit Amol A. , Mandlik Deepa S. , Mandlik Satish K. 
Published: July 2024

:
Cancer refers to a condition in which abnormal cells uncontrollably divide, resulting in
the destruction of tissues. In colorectal cancer, uncontrolled cell proliferation takes place in the rectum
or colon. Most colorectal tumors start as adenomas, a form of polyp that can develop into cancer
within the rectum or colon. Symptoms of colorectal cancer include chronic diarrhea or constipation,
bleeding from the rectum, bloody stools, change in appetite, weight loss, etc. Risk factors associated
with colorectal cancer are smoking, obesity, and low physical activity. Colorectal cancer
can be treated depending on size, location, and the spread of the cancer. Treatment includes surgery
where the lymph node is dissected and a colectomy is performed. Chemotherapy and radiation therapies
are other treatment options, but the main disadvantage is that these treatments have nonspecific
avenues. Apart from killing cancerous cells, they damage healthy cells, too. Therefore, with the
help of nanotechnology, drug-containing nanoparticles can be created with the aid of nanocarriers,
which are stronger, more durable, and site-specific. The cancerous cells can be actively targeted by
formulating nanoparticles loaded with anticancer drugs and functionalising the surface by either attaching
ligands (peptides, antibodies, and small molecules) or targeting molecules towards receptors
that are present on the exterior surface of the cancerous cells. These surfaces functionalised nanoparticles,
loaded with anticancer drugs, are significantly upregulated in cancerous cells in contrast
to healthy surrounding cells and tissues. This review article is focused on ligand-based drugs targeting
colorectal tumours.
Advancements in Micellar Formulation: Drug Delivery Vehicle for Water-Insoluble Drugs
Authors: Sharma Lokesh , Khurana Divya , Patel Preeti , Khare Satyam , Kurmi Balak Das 
Published: July 2024

:
Micellar systems, particularly polymeric micelles, have emerged as a promising drug delivery
vehicle for water-insoluble compounds. Polymeric micelles, self-assembled nanostructures
made from amphiphilic block copolymers, have emerged as a promising drug delivery vehicle for
water-insoluble compounds. These micelles offer high drug loading capacity, stability, and the ability
to solubilize large amounts of hydrophobic drugs, making them an attractive option for delivering
drugs with limited solubility and bioavailability. Their small size allows for efficient delivery
and targeting of specific tissues or cells, reducing off-target effects and improving therapeutic outcomes.
This review provides a brief overview of drug delivery system challenges, solutions, techniques
of micelle formation, factors affecting micelle stability and drug loading, applications,
pharmacokinetics and pharmacodynamics of micellar formulations, toxicological considerations,
limitations, recent advancements, and clinical trials of micelles in drug delivery. By addressing these
key aspects, this review seeks to provide a comprehensive understanding of the current status and
prospects of polymeric micelles as a promising drug delivery system.
Public Perceptions of Treating Opioid Use Disorder With Deep Brain Stimulation: Comment Analysis Study
Authors: Henegan Patricia , Koczara Jack , Bluhm Robyn , Cabrera Laura  Y 
Published: July 2024

Background
The number of opioid-related deaths in the United States has more than tripled over the past 7 years, with a steep increase beginning at the same time as the COVID-19 pandemic. There is an urgent need for novel treatment options that can help alleviate the individual and social effects of refractory opioid use disorder (OUD). Deep brain stimulation (DBS), an intervention that involves implanting electrodes in the brain to deliver electrical impulses, is one potential treatment. Currently in clinical trials for many psychiatric conditions, including OUD, DBS’s use for psychiatric indications is not without controversy. Several studies have examined ethical issues raised by using DBS to counter treatment-resistant depression, obsessive-compulsive disorder, and eating disorders. In contrast, there has been limited literature regarding the use of DBS for OUD.

Objective
This study aims to gain empirical neuroethical insights into public perceptions regarding the use of DBS for OUD, specifically via the analysis of web-based comments on news media stories about the topic.

Methods
Qualitative thematic content analysis was performed on 2 Washington Post newspaper stories that described a case of DBS being used to treat OUD. A total of 292 comments were included in the analysis, 146 comments from each story, to identify predominant themes raised by commenters.

Results
Predominant themes raised by commenters across the 2 samples included the hopes and expectations with treatment outcomes, whether addiction is a mental health disorder, and issues related to resource allocation. Controversial comments regarding DBS as a treatment method for OUD seemingly decreased when comparing the first printed newspaper story to the second. In comparison, the number of comments relating to therapeutic need increased over time.

Conclusions
The general public’s perspectives on DBS as a treatment method for OUD elucidated themes via this qualitative thematic content analysis that include overarching sociopolitical issues, positions on the use of technology, and technological and scientific issues. A better understanding of the public perceptions around the use of DBS for OUD can help address misinformation and misperceptions about the use of DBS for OUD, and identify similarities and differences regarding ethical concerns when DBS is used specifically for OUD compared to other psychiatric disorders.
Composición corporal y consumo máximo de oxígeno en una muestra de estudiantes universitarios de la ciudad de Villavicencio
Authors: Santamaría Niño Oscar Mauricio , Mejía Garzón Marelliy , Torres Aragón Nelson 
Published: July 2024

Con el objetivo de relacionar la composición corporal con el consumo máximo de oxígeno (VO2max) en una muestra de estudiantes universitarios de la ciudad de Villavicencio, Colombia, se realizó un estudio observacional, prospectivo, con alcance descriptivo y correlacional de corte transversal, en una muestra de 390 sujetos (190 hombres y 200 mujeres) de cuatro instituciones de educación superior (IES), con una edad media de 21,54 ± 4, años. Fueron medidos peso, talla, pliegues cutáneos (tricipital, subescapular, pierna media) y perímetro abdominal y calculados IMC, porcentaje de grasa con los protocolos ISAK y VO2max con el Queen’s College Step Test. Los datos fueron tratados con el programa SPSS, versión 20, en español. Se contó con el aval del comité de bioética de la Universidad de los Llanos. Los participantes firmaron un consentimiento informado. Los resultados arrojaron que un 20,7% presentó sobrepeso, 3,3% obesidad y 9% infrapeso; el VO2max estuvo en una media de 38,4 mL/kg/min, un mínimo de 19 mL/kg/min y un máximo de 78 mL/kg/min. La muestra evaluada respecto al infrapeso evidenció un mayor porcentaje en hombres que en mujeres; el peso normal más bajo se ubicó en hombres; de igual forma, el porcentaje de sobrepeso se encontró en hombres. Estos datos dejan en evidencia al grupo de los hombres, que estuvieron más inclinados hacia los extremos menos favorables de acuerdo con las categorías normales que expresa la OMS.