bluuebunny/crossref_metadata_2025_split huggingface dataset:
PsyGeCo – Psychisch Gesund in Zeiten von Corona
Authors: Çelik Fatma , Schäfermeier Esther , Stelzmann Daniela , Arraf Samia , Matthies Eliane , Bremerich Laurin , Roggenkamp Stefan , Schneider Silvia , Schopf Kathrin 
Published: July 2024

Zusammenfassung: Die Adoleszenz gilt aufgrund intensiver Veränderungsprozesse nicht nur als vulnerable Phase für Fehlanpassungen, sondern auch als sensible Phase für Interventionen. Neben normativen Herausforderungen hat die COVID-19-Pandemie als nicht normative Krise zu einer erhöhten Belastung in dieser Altersgruppe geführt. In der Bewältigung dieser Herausforderungen gilt die allgemeine Selbstwirksamkeit (SWE) als Schutzfaktor, die im Rahmen der vorgestellten ressourcenorientierten Maßnahme gestärkt werden sollte. Zur Prüfung der Akzeptanz und Wirksamkeit der manualisierten Maßnahme wurde eine Wirksamkeitsstudie mit Prä-Post-Design ( t0- t2) durchgeführt und evaluiert. An der Maßnahme haben N=192 Jugendliche (Range: 12 – 17 Jahre) teilgenommen. Es zeigte sich ein kurzfristiger, kleiner Effekt auf die SWE, welcher im Follow-up nicht mehr nachweisbar war. Die differentielle Wirksamkeit der Maßnahme wird vor dem Hintergrund von Faktoren wie der gesundheitsbezogenen Lebensqualität und dem sozioökonomischen Status diskutiert.
Thermal and Dynamo Evolution of the Lunar Core Based on the Transport Properties of Fe‐S‐P Alloys
Authors: Zhai Kuan , Yin Yuan , Zhai Shuangmeng 
Published: July 2024

AbstractPaleomagnetic analyses have suggested that the lunar magnetic field underwent a significant change from 4.25 to 3.19 Ga, indicating the rapid transition of the lunar dynamo mechanism. We used the van der Pauw (vdP) method to measure the electrical resistivity of Fe‐S‐P alloys under conditions relevant to the lunar core and estimated the thermal conductivity of the Fe‐S‐P lunar core. These values were incorporated into thermal and dynamo models to investigate the evolution of the lunar core. Our model indicates that the inner core began to grow as early as 4.35 Ga, the solidification regime switched at 3.50 Ga, and the thermal dynamo ceased between 3.78 and 3.51 Ga. The cessation of the dynamo could be due to a low buoyancy flux and insufficient entropy dissipation. Thermal and compositional dynamos cannot sustain the ancient strength of the Moon's magnetic field, and require other energy sources.
Earth's Sea Ice Radiative Effect From 1980 to 2023
Authors: Duspayev A. , Flanner M. G. , Riihelä A. 
Published: July 2024

AbstractSea ice cools Earth by reducing its absorbed solar energy. We combine radiative transfer modeling with satellite‐derived surface albedo, sea ice, and cloud distributions to quantify the top‐of‐atmosphere sea ice radiative effect (SIRE). Averaged over 1980–2023, Arctic and Antarctic SIREs range from −0.64 to −0.86 W m−2 and −0.85 to −0.98 W m−2, respectively, with different cloud data sets and assumptions of climatological versus annually‐varying clouds. SIRE trends, however, are relatively insensitive to these assumptions. Arctic SIRE has weakened quasi‐linearly at a rate of 0.04–0.05 W m−2 decade−1, implying a 21%–27% reduction in the reflective power of Arctic sea ice since 1980. Antarctic sea ice exhibited a regime change in 2016, resulting in 2016–2023 Antarctic and global SIRE being 0.08–0.12 and 0.22–0.27 W m−2 weaker, respectively, relative to 1980–1988. Global sea ice has therefore lost 13%–15% of its planetary cooling effect since the early/mid 1980s, and the implied global sea ice albedo feedback is 0.24–0.38 W m−2 K−1.
Full Modeling and Practical Parameterization of Cosmogenic 10Be Transport for Cosmic‐Ray Studies: SOCOL‐AERv2‐BE Model
Authors: Golubenko K. , Rozanov E. , Kovaltsov G. , Baroni M. , Sukhodolov T. , Usoskin I. 
Published: July 2024

AbstractA new full model of the atmospheric transport of cosmogenic 10Be is presented based on the specialized SOCOL‐AERv2‐BE chemistry‐climate model coupled with the CRAC:10Be isotope production model. The model includes all the relevant atmospheric processes and allows computing the isotope concentration at any given location and time. The full model is directly compared with 10Be isotope measurements in five Antarctic and Greenland ice cores for the period 1980–2007. The model reasonably well reproduces the average concentration and solar‐cycle dependency or the lack of it for most observational sites but does not perfectly catch the interannual variability at sites with complex orography likely due to the coarse model grid. This implies that the model correctly reproduces the large‐scale atmospheric dynamics but effectively averages out synoptic‐scale variability. It is found that the dominant source of 10Be is located in the middle stratosphere (25–40 km), in the tropical (<30° latitudes) and polar (>60°) regions, as produced by galactic cosmic rays and solar energetic particles, respectively. It is shown that >60% (90%) of 10Be produced in the atmosphere reaches the Earth's surface within one (two) years, respectively. For practical purposes, a simple parameterization of the full‐model results is presented which agrees with the full model within 20% in polar regions. This parameterization allows one to make a quick estimate of near‐ground 10Be concentrations based only on production rates without heavy calculations. This practical approach can be applied to studies of solar and geomagnetic variability using cosmogenic isotopes.
Bacterial persisters: molecular mechanisms and therapeutic development
Authors: Niu Hongxia , Gu Jiaying , Zhang Ying 
Published: July 2024

AbstractPersisters refer to genetically drug susceptible quiescent (non-growing or slow growing) bacteria that survive in stress environments such as antibiotic exposure, acidic and starvation conditions. These cells can regrow after stress removal and remain susceptible to the same stress. Persisters are underlying the problems of treating chronic and persistent infections and relapse infections after treatment, drug resistance development, and biofilm infections, and pose significant challenges for effective treatments. Understanding the characteristics and the exact mechanisms of persister formation, especially the key molecules that affect the formation and survival of the persisters is critical to more effective treatment of chronic and persistent infections. Currently, genes related to persister formation and survival are being discovered and confirmed, but the mechanisms by which bacteria form persisters are very complex, and there are still many unanswered questions. This article comprehensively summarizes the historical background of bacterial persisters, details their complex characteristics and their relationship with antibiotic tolerant and resistant bacteria, systematically elucidates the interplay between various bacterial biological processes and the formation of persister cells, as well as consolidates the diverse anti-persister compounds and treatments. We hope to provide theoretical background for in-depth research on mechanisms of persisters and suggest new ideas for choosing strategies for more effective treatment of persistent infections.
TNKS1BP1 facilitates ubiquitination of CNOT4 by TRIM21 to promote hepatocellular carcinoma progression and immune evasion
Authors: Wang Yuan , Sandrine Ineza Karambizi , Ma Li , Chen Kailang , Chen Xinyi , Yu Yulong , Wang Sheng , Xiao Lingyan , Li Chunya , Liu Yuanhui , Liu Bo , Yuan Xianglin 
Published: July 2024

AbstractImmune checkpoint inhibitors, particularly PD-1/PD-L1 blockades, have been approved for unresectable hepatocellular carcinoma (HCC). However, high resistance rates still limit their efficacy, highlighting the urgent need to understand the underlying mechanisms and develop strategies for overcoming the resistance. In this study, tankyrasel binding protein 1 (TNKS1BP1) was found to interact with tripartite motif containing 21 (TRIM21) and mediated the ubiquitination of CCR4-NOT transcription complex subunit 4 (CNOT4) at the K239 residue via K48 and K6 linkage, which was essential for its tumorigenesis function. Autophagy and lipid reprogramming were identified as two possible mechanisms underlying the pro-tumor effect of TNKS1BP1. Upregulated TNKS1BP1 inhibited autophagy while induced lipid accumulation by inhibiting the JAK2/STAT3 pathway upon the degradation of CNOT4 in HCC. Importantly, knocking down TNKS1BP1 synergized with anti-PD-L1 treatment by upregulating PD-L1 expression on tumor cells via the JAK2/STAT3 pathway, and remodeling the tumor microenvironment by increasing infiltration of tumor-infiltrating lymphocytes as well as augmenting the effect of cytotoxic T lymphocytes. In conclusion, this study identified TNKS1BP1 as a predictive biomarker for patient prognosis and a promising therapeutic target to overcome anti-PD-L1 resistance in HCC.
Visualization and standardized quantification of surface charge density for triboelectric materials
Authors: Li Yi , Luo Yi , Xiao Song , Zhang Cheng , Pan Cheng , Zeng Fuping , Cui Zhaolun , Huang Bangdou , Tang Ju , Shao Tao , Zhang Xiaoxing , Xiong Jiaqing , Wang Zhong Lin 
Published: July 2024

AbstractTriboelectric nanogenerator (TENG) operates on the principle of utilizing contact electrification and electrostatic induction. However, visualization and standardized quantification of surface charges for triboelectric materials remain challenging. Here, we report a surface charge visualization and standardized quantification method using electrostatic surface potential measured by Kevin probe and the iterative regularization strategy. Moreover, a tuning strategy on surface charge is demonstrated based on the corona discharge with a three-electrode design. The long-term stability and dissipation mechanisms of the injected negative or positive charges demonstrate high dependence on deep carrier traps in triboelectric materials. Typically, we achieved a 70-fold enhancement on the output voltage (~135.7 V) for the identical polytetrafluoroethylene (PTFE) based TENG (neg-PTFE/PTFE or posi-PTFE/PTFE triboelectric pair) with stable surface charge density (5% decay after 140 days). The charged PTFE was demonstrated as a robot e-skins for non-contact perception of object geometrics. This work provides valuable tools for surface charge visualization and quantification, giving a new strategy for a deeper understanding of contact electrification.
Host-derived protein profiles of human neonatal meconium across gestational ages
Authors: Shitara Yoshihiko , Konno Ryo , Yoshihara Masahito , Kashima Kohei , Ito Atsushi , Mukai Takeo , Kimoto Goh , Kakiuchi Satsuki , Ishikawa Masaki , Kakihara Tomo , Nagamatsu Takeshi , Takahashi Naoto , Fujishiro Jun , Kawakami Eiryo , Ohara Osamu , Kawashima Yusuke , Watanabe Eiichiro 
Published: July 2024

AbstractMeconium, a non-invasive biomaterial reflecting prenatal substance accumulation, could provide valuable insights into neonatal health. However, the comprehensive protein profile of meconium across gestational ages remains unclear. Here, we conducted an extensive proteomic analysis of first meconium from 259 newborns across varied gestational ages to delineate protein composition and elucidate its relevance to neonatal diseases. The first meconium samples were collected, with the majority obtained before feeding, and the mean time for the first meconium passage from the anus was 11.9 ± 9.47 h. Our analysis revealed 5370 host-derived meconium proteins, which varied depending on sex and gestational age. Specifically, meconium from preterm infants exhibited elevated concentrations of proteins associated with the extracellular matrix. Additionally, the protein profiles of meconium also exhibited unique variations depending on both specific diseases, including gastrointestinal diseases, congenital heart diseases, and maternal conditions. Furthermore, we developed a machine learning model to predict gestational ages using meconium proteins. Our model suggests that newborns with gastrointestinal diseases and congenital heart diseases may have immature gastrointestinal systems. These findings highlight the intricate relationship between clinical parameters and meconium protein composition, offering potential for a novel approach to assess neonatal gastrointestinal health.
Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule
Authors: Qin Chuan , Graf Leonie G. , Striska Kilian , Janetzky Markus , Geist Norman , Specht Robin , Schulze Sabrina , Palm Gottfried J. , Girbardt Britta , Dörre Babett , Berndt Leona , Kemnitz Stefan , Doerr Mark , Bornscheuer Uwe T. , Delcea Mihaela , Lammers Michael 
Published: July 2024

AbstractThe AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria and eukaryotes. However, the underlying mechanism is poorly understood. The Bacillus subtilis acetyltransferase AcuA and the AMP-forming acetyl-CoA synthetase AcsA form an AcuA•AcsA complex, dissociating upon lysine acetylation of AcsA by AcuA. Crystal structures of AcsA from Chloroflexota bacterium in the apo form and in complex with acetyl-adenosine-5′-monophosphate (acetyl-AMP) support the flexible C-terminal domain adopting different conformations. AlphaFold2 predictions suggest binding of AcuA stabilizes AcsA in an undescribed conformation. We show the AcuA•AcsA complex dissociates upon acetyl-coenzyme A (acetyl-CoA) dependent acetylation of AcsA by AcuA. We discover an intrinsic phosphotransacetylase activity enabling AcuA•AcsA generating acetyl-CoA from acetyl-phosphate (AcP) and coenzyme A (CoA) used by AcuA to acetylate and inactivate AcsA. Here, we provide mechanistic insights into the regulation of AMP-forming acetyl-CoA synthetases by lysine acetylation and discover an intrinsic phosphotransacetylase allowing modulation of its activity based on AcP and CoA levels.
Footprint of sustained poleward warm water flow within East Antarctic submarine canyons
Authors: Donda Federica , Rebesco Michele , Kovacevic Vedrana , Silvano Alessandro , Bensi Manuel , De Santis Laura , Rosenthal Yair , Torricella Fiorenza , Baradello Luca , Gei Davide , Leventer Amy , Post Alix , Leitchenkov German , Noble Taryn , Zgur Fabrizio , Cova Andrea , O’Brien Philip , Romeo Roberto 
Published: July 2024

AbstractThe intrusion of relatively warm water onto the continental shelf is widely recognized as a threat to Antarctic ice shelves and glaciers grounded below sea level, as enhanced ocean heat increases their basal melt. While the circulation of warm water has been documented on the East Antarctic continental shelf, the modes of warm water transport from the deep ocean onto the shelf are still uncertain. This makes predicting the future responses of major East Antarctic marine-grounded glaciers, such as Totten and Ninnis glaciers, particularly challenging. Here, we outline the key role of submarine canyons to convey southward flowing currents that transport warm Circumpolar Deep Water toward the East Antarctic shelf break, thus facilitating warm water intrusion on the continental shelf. Sediment drifts on the eastern flank of the canyons provide evidence for sustained southward-directed flows. These morpho-sedimentary features thus highlight areas potentially prone to enhanced ocean heat transport toward the continental shelf, with repercussions for past, present, and future glacial melting and consequent sea level rise.
Node-layer duality in networked systems
Authors: Presigny Charley , Corsi Marie-Constance , De Vico Fallani Fabrizio 
Published: July 2024

AbstractReal-world networks typically exhibit several aspects, or layers, of interactions among their nodes. By permuting the role of the nodes and the layers, we establish a new criterion to construct the dual of a network. This approach allows to examine connectivity from either a node-centric or layer-centric viewpoint. Through rigorous analytical methods and extensive simulations, we demonstrate that nodewise and layerwise connectivity measure different but related aspects of the same system. Leveraging node-layer duality provides complementary insights, enabling a deeper comprehension of diverse networks across social science, technology and biology. Taken together, these findings reveal previously unappreciated features of complex systems and provide a fresh tool for delving into their structure and dynamics.
Asymmetric Ru-In atomic pairs promote highly active and stable acetylene hydrochlorination
Authors: Fan Yurui , Xu Haomiao , Gao Guanqun , Wang Mingming , Huang Wenjun , Ma Lei , Yao Yancai , Qu Zan , Xie Pengfei , Dai Bin , Yan Naiqiang 
Published: July 2024

AbstractRu single-atom catalysts have great potential to replace toxic mercuric chloride in acetylene hydrochlorination. However, long-term catalytic stability remains a grand challenge due to the aggregation of Ru atoms caused by over-chlorination. Herein, we synthesize an asymmetric Ru-In atomic pair with vinyl chloride monomer yield (>99.5%) and stability (>600 h) at a gas hourly space velocity of 180 h−1, far surpassing those of the Ru single-atom counterparts. A combination of experimental and theoretical techniques reveals that there is a strong d-p orbital interaction between Ru and In atoms, which not only enables the selective adsorption of acetylene and hydrogen chloride at different atomic sites but also optimizes the electron configuration of Ru. As a result, the intrinsic energy barrier for vinyl chloride generation is lowered, and the thermodynamics of the chlorination process at the Ru site is switched from exothermal to endothermal due to the change of orbital couplings. This work provides a strategy to prevent the deactivation and depletion of active Ru centers during acetylene hydrochlorination.
The impact of insect herbivory on biogeochemical cycling in broadleaved forests varies with temperature
Authors: Hwang Bernice C. , Giardina Christian P. , Adu-Bredu Stephen , Barrios-Garcia M. Noelia , Calvo-Alvarado Julio C. , Dargie Greta C. , Diao Haoyu , Duboscq-Carra Virginia G. , Hemp Andreas , Hemp Claudia , Huasco Walter Huaraca , Ivanov Aleksandr V. , Johnson Nels G. , Kuijper Dries P. J. , Lewis Simon L. , Lobos-Catalán Paulina , Malhi Yadvinder , Marshall Andrew R. , Mumladze Levan , Ngute Alain Senghor K. , Palma Ana C. , Petritan Ion Catalin , Rordriguez-Cabal Mariano A. , Suspense Ifo A. , Zagidullina Asiia , Andersson Tommi , Galiano-Cabrera Darcy F. , Jiménez-Castillo Mylthon , Churski Marcin , Gage Shelley A. , Filippova Nina , Francisco Kainana S. , Gaglianese-Woody Morgan , Iankoshvili Giorgi , Kaswamila Mgeta Adidas , Lyatuu Herman , Mampouya Wenina Y. E. , Materu Brayan , Mbemba M. , Moritz Ruslan , Orang Karma , Plyusnin Sergey , Puma Vilca Beisit L. , Rodríguez-Solís Maria , Šamonil Pavel , Stępniak Kinga M. , Walsh Seana K. , Xu Han , Metcalfe Daniel B. 
Published: July 2024

AbstractHerbivorous insects alter biogeochemical cycling within forests, but the magnitude of these impacts, their global variation, and drivers of this variation remain poorly understood. To address this knowledge gap and help improve biogeochemical models, we established a global network of 74 plots within 40 mature, undisturbed broadleaved forests. We analyzed freshly senesced and green leaves for carbon, nitrogen, phosphorus and silica concentrations, foliar production and herbivory, and stand-level nutrient fluxes. We show more nutrient release by insect herbivores at non-outbreak levels in tropical forests than temperate and boreal forests, that these fluxes increase strongly with mean annual temperature, and that they exceed atmospheric deposition inputs in some localities. Thus, background levels of insect herbivory are sufficiently large to both alter ecosystem element cycling and influence terrestrial carbon cycling. Further, climate can affect interactions between natural populations of plants and herbivores with important consequences for global biogeochemical cycles across broadleaved forests.
Anti-distortion bioinspired camera with an inhomogeneous photo-pixel array
Authors: Choi Changsoon , Hinton Henry , Seung Hyojin , Chang Sehui , Kim Ji Su , You Woosang , Kim Min Sung , Hong Jung Pyo , Lim Jung Ah , Hwang Do Kyung , Lee Gil Ju , Jang Houk , Song Young Min , Kim Dae-Hyeong , Ham Donhee 
Published: July 2024

AbstractThe bioinspired camera, comprising a single lens and a curved image sensor—a photodiode array on a curved surface—, was born of flexible electronics. Its economical build lends itself well to space-constrained machine vision applications. The curved sensor, much akin to the retina, helps image focusing, but the curvature also creates a problem of image distortion, which can undermine machine vision tasks such as object recognition. Here we report an anti-distortion single-lens camera, where 4096 silicon photodiodes arrayed on a curved surface in a nonuniform pattern assimilated to the distorting optics are the key to anti-distortion engineering. That is, the photo-pixel distribution pattern itself is warped in the same manner as images are warped, which correctively reverses distortion. Acquired images feature no appreciable distortion across a 120° horizontal view, as confirmed by their neural-network recognition accuracies. This distortion correction via photo-pixel array reconfiguration is a form of in-sensor computing.
Seed dispersal by Martu peoples promotes the distribution of native plants in arid Australia
Authors: Bliege Bird Rebecca , Bird Douglas W. , Martine Christopher T. , McGuire Chloe , Greenwood Leanne , Taylor Desmond , Williams Tanisha M. , Veth Peter M. 
Published: July 2024

AbstractCommensal relationships between wild plants and their dispersers play a key ecological and evolutionary role in community structure and function. While non-human dispersers are often considered critical to plant recruitment, human dispersers have received much less attention, especially when it comes to non-domesticated plants. Australia, as a continent historically characterized by economies reliant on non-domesticated plants, is thus a key system for exploring the ecological role of people as seed dispersers in the absence of agriculture. Here, we utilize a controlled observation research design, employing ecological surveys and ethnographic observations to examine how seed dispersal and landscape burning by Martu Aboriginal people affects the distribution of three preferred plants and one (edible, but non-preferred) control species. Using an information theoretic approach, we find that the three preferred plants show evidence of human dispersal, with the strongest evidence supporting anthropogenic dispersal for the wild bush tomato, Solanum diversiflorum.