bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recognition and Excision Properties of 8‐Halogenated‐7‐Deaza‐2′‐Deoxyguanosine as 8‐Oxo‐2′‐Deoxyguanosine Analogues and Fpg and hOGG1 Inhibitors
Authors: Yin Yizhen , Sasaki Shigeki , Taniguchi Yosuke 
Published: April 2015

AbstractCellular DNA continuously suffers various types of damage, and unrepaired damage increases disease progression risk. 8‐Oxo‐2′‐deoxyguanine (8‐oxo‐dG) is excised by repair enzymes, and their analogues are of interest as inhibitors and as bioprobes for study of these enzymes. We have developed 8‐halogenated‐7‐deaza‐2′‐deoxyguanosine derivatives that resemble 8‐oxo‐dG in that they adopt the syn conformation. In this study, we investigated their effects on Fpg (formamidopyrimidine DNA glycosylase) and hOGG1 (human 8‐oxoguanine DNA N‐glycosylase 1). Relative to 8‐oxo‐dG, Cl‐ and Br‐deaza‐dG were good substrates for Fpg, whereas they were less efficient substrates for hOGG1. Kinetics and binding experiments indicated that, although hOGG1 effectively binds Cl‐ and Br‐deaza‐dG analogues with low Km values, their lower kcat values result in low glycosylase activities. The benefits of the high binding affinities and low reactivities of 8‐oxo‐dG analogues with hOGG1 have been successfully applied to the competitive inhibition of the excision of 8‐oxoguanine from duplex DNA by hOGG1.
Glucose Electrooxidation in Bimetallic Suspensions of Nanoparticles in Alkaline Media
Authors: Dolinska Joanna , Kannan Palanisamy , Sobczak Janusz W. , Opallo Marcin 
Published: April 2015

AbstractGlucose electrooxidation at a glassy carbon rotating disk electrode in an alkaline bimetallic suspension of Au and Pt nanoparticles is studied. The voltammetric current density is approximately fourfold larger than measured for Pt nanoparticles in suspension and three orders of magnitude larger than observed for a suspension of Au nanoparticles. The features of these voltammograms are classically different from voltammograms obtained for suspensions of Au or Pt nanoparticles under the same conditions. The most significant voltammetric signal arises mainly from the electrocatalytic oxidation of glucose at nanoparticles adsorbed on the glassy carbon electrode.
Reversible Lysine Modification on Proteins by Using Functionalized Boronic Acids
Authors: Cal Pedro M. S. D. , Frade Raquel F. M. , Cordeiro Carlos , Gois Pedro M. P. 
Published: April 2015

AbstractIminoboronates have been utilized to successfully install azide and alkyne bioorthogonal functions on proteins, which may then be further reacted with their bioorthogonal counterparts. These constructs were also used to add polyethylene glycol (PEG) to insulin, a modification which has been shown to be reversible in the presence of fructose. Finally, iminoboronates were used to assemble a folic acid/paclitaxel small‐molecule/drug conjugate in situ with an IC50 value of 20.7 nM against NCI‐H460 cancer cells and negligible cytotoxicity against the CRL‐1502 noncancer cells.
Sensing of Double‐Stranded DNA/RNA Secondary Structures by Water Soluble Homochiral Perylene Bisimide Dyes
Authors: Gershberg Jana , Radić Stojković Marijana , Škugor Marko , Tomić Sanja , Rehm Thomas H. , Rehm Stefanie , Saha‐Möller Chantu R. , Piantanida Ivo , Würthner Frank 
Published: April 2015

AbstractA broad series of homochiral perylene bisimide (PBI) dyes were synthesized that are appended with amino acids and cationic side chains at the imide positions. Self‐assembly behavior of these ionic PBIs has been studied in aqueous media by UV/Vis spectroscopy, revealing formation of excitonically coupled H‐type aggregates. The interactions of these ionic PBIs with different ds‐DNA and ds‐RNA have been explored by thermal denaturation, fluorimetric titration and circular dichroism (CD) experiments. These PBIs strongly stabilized ds‐DNA/RNA against thermal denaturation as revealed by high melting temperatures of the formed PBI/polynucleotide complexes. Fluorimetric titrations showed that these PBIs bind to ds‐DNA/RNA with high binding constants depending on the number of the positive charges in the side chains. Thus, spermine‐containing PBIs with six positive charges each showed higher binding constants (logKs=9.2–9.8) than their dioxa analogues (logKs=6.5–7.9) having two positive charges each. Induced circular dichroism (ICD) of PBI assemblies created within DNA/RNA grooves was observed. These ICD profiles are strongly dependent on the steric demand of the chiral substituents of the amino acid units and the secondary structure of the DNA or RNA. The observed ICD effects can be explained by non‐covalent binding of excitonically coupled PBI dimer aggregates into the minor groove of DNA and major groove of RNA which is further supported by molecular modeling studies.
Explosive Decomposition of a Melamine–Cyanuric Acid Supramolecular Assembly for Fabricating Defect‐Rich Nitrogen‐Doped Carbon Nanotubes with Significantly Promoted Catalysis
Authors: Zhao Zhongkui , Dai Yitao , Ge Guifang , Wang Guiru 
Published: April 2015

AbstractA facile and scalable approach for fabricating structural defect‐rich nitrogen‐doped carbon nanotubes (MCSA‐CNTs) through explosive decomposition of melamine–cyanuric acid supramolecular assembly is presented. In comparison to pristine carbon nanotubes, MCSA‐CNT exhibits significantly enhanced catalytic performance in oxidant‐ and steam‐free direct dehydrogenation of ethylbenzene, demonstrating the potential for metal‐free clean and energy‐saving styrene production. This finding also opens a new horizon for preparing highly‐efficient carbocatalysts rich in structural defect sites for diverse transformations.
Palladium‐Catalyzed Domino CH/NH Functionalization: An Efficient Approach to Nitrogen‐Bridged Heteroacenes
Authors: Kamimoto Natsuyo , Schollmeyer Dieter , Mitsudo Koichi , Suga Seiji , Waldvogel Siegfried R. 
Published: April 2015

AbstractPalladium‐catalyzed domino CH/NH functionalization for the synthesis of novel nitrogen‐bridged thienoacenes and 10H‐benzo[4,5]thieno[3,2‐b]indole derivatives from dihaloarene is reported. This domino sequence consists of initial CH functionalization of the benzo[b]thiophene moiety, followed by Buchwald–Hartwig coupling. This transformation is also useful for the synthesis of highly π‐extended compounds.
Polymorphism in New Thienothiophene–Thiazolothiazole Organic Semiconductors
Authors: Schneider Julia A. , Black Hayden T. , Lin Hua‐Ping , Perepichka Dmitrii F. 
Published: April 2015

AbstractThe front cover artwork is provided by J. A. Schneider from D. Perepichka’s group (McGill University). The image shows two packing motifs of the same organic semiconductor, which either hinder or facilitate charge transport. In the foreground the crystal polymorphs and a single crystal field‐effect transistor are pictured. Read the full text of the article at 10.1002/cphc.201500066.
Trends in the incidence of diabetes, its clinical sequelae, and associated costs in pregnancy
Authors: Jovanovič Lois , Liang Yuanjie , Weng Wayne , Hamilton Marianthe , Chen Lisa , Wintfeld Neil 
Published: April 2015

AbstractBackgroundIncreasing diabetes prevalence affects a substantial number of pregnant women in the United States. Our aims were to evaluate health outcomes, medical costs, risks and types of complications associated with diabetes in pregnancy for mothers and newborns.MethodsIn this retrospective claims analysis, patients were identified from the Truven Health MarketScan® database (2004–2011 inclusive). Participants were aged 18–45 years, with ascertainable diabetes status [Yes/No], date of birth event >2005 and continuous health plan enrolment ≥21 months before and 3 months after the birth.ResultsIn total, 839 792 pregnancies were identified, and 66 041 (7.86%) were associated with diabetes mellitus [type 1 (T1DM), 0.13%; type 2 (T2DM), 1.21%; gestational (GDM), 6.29%; and GDM progressing to T2DM (patients without prior diabetes who had a T2DM diagnosis after the birth event), 0.23%]. Relative risk (RR) of stillbirth (2.51), miscarriage (1.28) and Caesarean section (C‐section) (1.77) was significantly greater with T2DM versus non‐diabetes. Risk of C‐section was also significantly greater for other diabetes types [RR 1.92 (T1DM); 1.37 (GDM); 1.63 (GDM progressing to T2DM)]. Risk of overall major congenital (RR ≥ 1.17), major congenital circulatory (RR ≥ 1.19) or major congenital heart (RR ≥ 1.18) complications was greater in newborns of mothers with diabetes versus without. Mothers with T2DM had significantly higher risk (RR ≥ 1.36) of anaemia, depression, hypertension, infection, migraine, or cardiac, obstetrical or respiratory complications than non‐diabetes patients. Mean medical costs were higher with all diabetes types, particularly T1DM ($27 531), than non‐diabetes ($14 355).ConclusionsComplications and costs of healthcare were greater with diabetes, highlighting the need to optimize diabetes management in pregnancy. © 2015 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons, Ltd.
Hydrogen Bond Controlled Anti‐Aza‐Michael Addition: Diastereoselective Synthesis of Cyclobutene‐Containing Amino Acid Derivatives
Authors: Tejedor David , Méndez‐Abt Gabriela , González‐Platas Javier , Fernández Israel , García‐Tellado Fernando 
Published: April 2015

AbstractThe chemical reactivity encoded in a highly substituted cyclobutane platform, which contains the (E,E)‐dimethyl 2,2′‐(cyclobutane‐1,2‐diylidene)diacetate structural motif, has been explored. The cyclobutane platform features a C2 axis of symmetry as well as a dense and interconnected ring functionalization pattern that is defined by two allylic/benzylic stereogenic oxygen‐containing quaternary centers with a 1,2‐trans configuration and two exocyclic acrylate chains. The reactivity profile of the cyclobutane platform is defined by two important kinetic barriers (steric strain and antiaromaticity) and two structure‐biased chemical processes: (1) the thermally‐driven [3,3] sigmatropic rearrangement between one of the two equivalent aryloates and the corresponding allylic acrylate chain and (2) the allylic nucleophilic substitution (SN2′ reaction) that involves a tertiary aryloate and its exocyclic double bond (anti‐Michael addition). The reaction of platform 3a with secondary amines delivered the corresponding cyclobutene amino acid derivatives 15a–15f in excellent yields (up to ≥95 %) and high diastereoselectivities (up to 99:1). Computational studies are described to rationalize the observed diastereoselectivity.
Preparation and Crystal Structure of the 1,3‐alternate Atropisomer of a Calix[4]radialene
Authors: Itzhak Norbert , Biali Silvio E. 
Published: April 2015

AbstractAlkylation of the tetrahydroxy‐tetraoxocalix[4]arene 5 with n‐butyl bromide proceeds in a stereoselective fashion and affords exclusively a single atropisomer of the tetraoxocalix[4]arene tetrabutyl ether derivative. Reaction with MeLi followed by fourfold acid‐catalyzed elimination of water affords the rigid calix[4]radialene 8. The crystal structure of 8 corroborated the proposed calixradialene structure and indicated an 1,3‐alternate arrangement of the rings.
Separators for Lithium‐Ion Batteries: A Review on the Production Processes and Recent Developments
Authors: Deimede Valadoula , Elmasides Costas 
Published: April 2015

AbstractRecently, much effort has been devoted to the development of battery separators for lithium‐ion batteries for high‐power, high‐energy applications ranging from portable electronics to large‐scale energy storage for power grids. The separator plays a key role in battery construction because it functions as the physical barrier to prevent electronic contact between the two electrodes and at the same time serves as an electrolyte reservoir, facilitating the ionic conduction. The purpose of this Review is to describe the requirements and properties of membrane separators for lithium‐ion batteries, the recent progress on the different types of separators developed, and the manufacturing methods used for their production. Specifically the large‐scale manufacturing processes are highlighted along with the processing parameters that affect their properties. The outlook and future directions regarding the development of advanced separator technologies are also discussed.
Assessment of driving factors for yield and productivity developments in crop and cattle production as key to increasing sustainable biomass potentials
Authors: Gerssen‐Gondelach Sarah , Wicke Birka , Faaij Andre 
Published: April 2015

AbstractThe sustainable production potential of biomass for energy and material purposes largely depends on the future availability of surplus agricultural lands made available through yield improvements in crop and livestock production. However, the rates at which yields may develop, and the influence of technological, economic and institutional factors on these growth rates are key uncertainties in assessing the potentials and impacts of biomass production. This study analyzes the pace and direction of historical yield developments (1961–2010) of five major crops, beef and cow milk in Australia, Brazil, China, India, USA, Zambia, and Zimbabwe, and examines the driving factors behind these developments. In addition, it explores how future yields are modeled and how modeling efforts may be improved. Average yield growth rates over the investigated period ranged in most cases between 0.7–1.6% year−1 for crops, 1.0–1.5% year−1 for milk, and 0.4–0.8% year−1 for beef (relative to 2010). The role of different drivers is region specific. Yet, supporting agricultural policies have played an important role in increasing yields in all countries, especially for crops. In cattle production, a key factor was the importance of commercial beef and milk production for the national or export market. Based on regional differences in drivers and yield developments, models that assess biomass potentials and impacts should take into account regional drivers, yield gaps, and potential policy pathways.
Greenhouse gas (GHG) emissions in the Sultanate of Oman
Authors: Abdul‐Wahab Sabah Ahmed , Charabi Yassine , Al‐Rawas Ghazi A. , Al‐Maamari Rashid , Gastli Adel , Chan Keziah 
Published: April 2015

AbstractWorldwide, many countries are being affected by greenhouse gas (GHG) emissions. The Sultanate of Oman is no exception. In Oman, both oil‐ and natural‐gas‐related activities have the most important shares of the nation's Gross Domestic Product (GDP). Hence, they are expected to be the primary cause of GHG emissions within the country. In this study, the greenhouse carbon dioxide emissions (CO2) released from the fossil fuels (i.e., oil and natural gas) used in the country for energy production purposes was computed by using the Intergovernmental Panel on Climate Change (IPCC) reference approach for National Greenhouse Gas Inventories. The objective was to develop the CO2 emissions for Oman over the last 40 years starting from year 1972. The obtained results indicated that Oman has a growth in its CO2 GHG emissions. This study is very important and essential, as it will assist Oman to monitor its progress in reducing CO2 emissions. © 2015 Society of Chemical Industry and John Wiley & Sons, Ltd
Clinical significance of melanoma‐associated antigen A1–6 expression in sputum of patients with squamous cell carcinoma of the larynx and hypopharynx
Authors: Lee Kang Dae , Lee Hyoung Shin , Kim Sung Won , Park Taejung , Hong Jong Chul , Chang Hee Kyung , Jung Sang Bong , Jeon Chang‐Ho , Park Jong Wook 
Published: April 2015

AbstractBackgroundSeveral studies have reported the expression of the melanoma‐associated antigen (MAGE) gene in head and neck squamous cell carcinoma (HNSCC). In this study, we evaluated the correlations between MAGE expression in sputum and the clinical features and oncologic outcomes of SCC of the larynx and hypopharynx.MethodsWe performed a retrospective review of 119 patients treated for SCC of the larynx and hypopharynx and analysis of their induced sputum by nested reverse transcription‐polymerase chain reaction (RT‐PCR) to detect the MAGE‐A1–6 gene. The associations between MAGE expression and clinical characteristics were analyzed.ResultsExpression of MAGE‐A1–6 in sputum was identified in 57 of 119 patients (47.9%), and was independently correlated to double primary cancer (p = .024; odds ratio [OR] = 4.135). Expression of MAGE‐A1–6 in sputum was correlated to poor survival.ConclusionExpression of MAGE‐A1–6 in sputum predicts poor oncologic outcome in patients with SCC of the larynx and hypopharynx. © 2015 Wiley Periodicals, Inc. Head Neck 38: E736–E740, 2016
Prognostic value of continued smoking on survival and recurrence rates in patients with head and neck cancer: A systematic review
Authors: van Imhoff Lieke C.R. , Kranenburg Gabriëlle G.J. , Macco Sven , Nijman Nicoline L. , van Overbeeke Elisabeth J. , Wegner Inge , Grolman Wilko , Pothen Ajit J. 
Published: April 2015

AbstractBackgroundThe purpose of this systematic review was to determine the prognostic value of continued smoking after diagnosis on survival and recurrence rates in head and neck cancer.MethodsA systematic search was performed and predefined inclusion and exclusion criteria were used to screen and select the articles. The remaining articles were critically appraised.ResultsSix articles were used for data extraction. The survival rate of patients who continued to smoke was 21% to 35% lower compared with patients who quit smoking. The recurrence rate for continued smoking was 23% and 30% higher. In 1 study, there was no difference between continuation and cessation of smoking, and 1 study showed a higher recurrence rate for patients who continued to smoke, which was not statistically significant.ConclusionThere is consistent evidence that survival rates are lower and recurrence rates are higher for patients who continue to smoke after being diagnosed with head and neck cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2214–E2220, 2016
Immunohistochemical predictors in squamous cell carcinoma of the tongue and floor of the mouth
Authors: Gontarz Michał , Wyszyńska–Pawelec Grażyna , Zapała Jan , Czopek Jacek , Lazar Agata , Tomaszewska Romana 
Published: April 2015

AbstractBackgroundThe purpose of this study was to evaluate the clinical usefulness of the immunoexpression of Ki‐67, matrix metalloproteinase (MMP)‐2, MMP‐9, vascular endothelial growth factor (VEGF)‐C, and VEGF‐D in predicting follow‐up treatment in patients with squamous cell carcinoma (SCC) of the tongue and floor of the mouth (FOM).MethodsMarker expression was evaluated in surgical specimens taken from 60 patients who underwent surgery because of primary SCC without prior therapy.ResultsStrong MMP‐2 expression was positively correlated with a higher risk of nodal recurrence (p = .047). Strong VEGF‐C expression was found in patients with distant metastases (p = .008). Cox's regression model showed high Ki‐67, MMP‐2, and VEGF‐C expression, which were independent predictors of disease‐specific survival (p = .001, p = .002, and p < .001, respectively).ConclusionIt seems that targeting MMP‐2 and VEGF‐C may improve local control, thereby reducing the risk of distant metastasis in patients with SCC of the tongue and FOM. © 2015 Wiley Periodicals, Inc. Head Neck 38: E747–E753, 2016
Free water elimination diffusion tractography: A comparison with conventional and fluid‐attenuated inversion recovery, diffusion tensor imaging acquisitions
Authors: Hoy Andrew R. , Kecskemeti Steven R. , Alexander Andrew L. 
Published: April 2015

PurposeWhite matter tractography reconstructions using conventional diffusion tensor imaging (DTI) near cerebrospinal fluid (CSF) spaces are often adversely affected by CSF partial volume effects (PVEs). This study evaluates the ability of free water elimination (FWE) DTI methods to minimize the PVE of CSF for deterministic tractography applications.Materials and MethodsTen healthy individuals were scanned with "traditional," FLAIR (fluid‐attenuated inversion recovery), and FWE DTI scans. The fornix, corpus callosum, and cingulum bundles were reconstructed using deterministic tractography. The FWE DTI scan was performed twice to separately match total acquisition time (long FWE) and number of measurements (encoding directions, short FWE) to the FLAIR and "traditional" DTI scans. PVE resolution was determined based on reconstructed tract volume. All reconstructions underwent blinded review for anatomical correctness, symmetry, and completeness.ResultsReconstructions of the fornix demonstrated that the FWE and FLAIR scans produce more complete, anatomically plausible reconstructions than "traditional" DTI. Additionally, the tract reconstructions using FWE‐DTI were significantly larger than when FLAIR was used with DTI (P < 0.0005). FLAIR and the FWE methods led to signal‐to‐noise ratio (SNR) reductions of 33% and 11%, respectively, compared with conventional DTI. The long and short FWE acquisitions did not significantly (P ≥ 0.31) differ from one another for any of the reconstructed tracts.ConclusionThe FWE diffusion model overcomes CSF PVE without the time, SNR, and volumetric coverage penalties inherent to FLAIR DTI. J. MAGN. RESON. IMAGING 2015;42:1572–1581.
Asymmetric modelling and control of an electronic throttle
Authors: Pujol Gisela , Vidal Yolanda , Acho Leonardo , Vargas Alessandro N. 
Published: April 2015

SummaryThis paper presents an improved model for an automotive electronic throttle inspired on the behaviour observed in real‐time experiments. Due to a number of issues, particularly the return‐spring, the performance of the throttle valve depends on whether it is opening or closing. This asymmetric behaviour was taken into account to design a mathematical model of the throttle body and to derive a nonlinear asymmetric Proportional Integral controller. The experimental demonstration suggests that considering an asymmetric term dramatically improves the performance of the controller. Copyright © 2015 John Wiley & Sons, Ltd.
The Kinetic Rate Law for the Autocatalytic Growth of Citrate‐Stabilized Silver Nanoparticles
Authors: Kytsya Andriy , Bazylyak Liliya , Hrynda Yuriy , Horechyy Andriy , Medvedevdkikh Yuriy 
Published: April 2015

ABSTRACTThe formation of sodium citrate stabilized spherical silver nanoparticles synthesized by homogeneous nucleation in aqua solutions was monitored by the method of direct potentiometry. It was observed that the kinetic curve of Ag+ ions reduction can be described by the Finke–Watzky (FW) autocatalytic two–step mechanism in the case of a large excess of hydrazine and NaOH. To expand the FW minimalistic model, the impact of the starting concentrations of the reagents on the kinetics of Ag nanoparticles synthesis was studied. It was determined that the nucleation stage is limited by the homogeneous process of ions Ag+ reduction, and the reaction orders for the all reagents are calculated. A surface–dependent model of Ag nanoparticle growth is proposed, which takes into account the change in the hydrazine and alkali concentrations; the rate constants of the pseudoelementary reactions are also calculated.