bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Spectral Characterization and Antimicrobial Activity of Some Transition Metal Complexes of 1,3‐Bis(1H‐benzimidazol‐2‐yl)‐2‐oxapropane
Authors: Tavman Aydin , Çinarli Adem , Gürbüz Demet , Tan A. Seher Birteksöz , Öksüzömer M. A. Faruk , Tüysüz Mayram , Gürkaynak Mehmet Ali , Yalçin Bahattin 
Published: September 2014

Abstract1,3‐Bis(1H‐benzimidazol‐2‐yl)‐2‐oxapropane (L) complexes with Fe(NO3)3, CoCl2, Co(NO3)2, Ni(NO3)2, CuCl2, Cu(ClO4)2, PdCl2, CdI2, Hg(NO3)2 were synthesized and characterized by elemental analysis, molar conductivity, magnetic moment, TGA, FT‐IR, NMR, ESI‐MS, fluorescence spectroscopy. Also, the crystal structure of 1,3‐bis(1H‐benzimidazol‐2‐yl)‐2‐oxapropane]dichlorocobalt(II), [Co(L)Cl2], complex is reported that it has distorted trigonal bipyramidal geometry. Antibacterial activities of the compounds were evaluated using the disk diffusion method against six bacteria and Candida albicans. The Hg(II) complex shows superior activity toward S. epidermidis and E. coli whereas the other complexes are ineffective except the Co(NO3)2 complex: it showed weak activity toward all of the microorganisms.
Application of Nanosized Cu0.5Co0.5Fe2O4 Spinel Ferrite as a Nanocatalyst in the Synthesis of 14‐Aryl‐14H‐dibenzo[a,j]xanthene Derivatives under Solvent‐free Conditions
Authors: Fareghi‐Alamdari Reza , Golestanzadeh Mohsen , Zekri Negar 
Published: September 2014

AbstractCopper and cobalt substituted spinel ferrites Cu1‐xCoxFe2O4 (0≤X≤1) have been synthesized by using hydrothermal method. The resultant spinel ferrites were systematically characterized by different techniques such as X‐ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X‐ray spectroscopy (EDX), and Fourier transform infrared spectroscopy (FT‐IR). It was indicated that all the resultant spinel ferrites obtained by the hydrothermal method had the single‐phase crystalline. The resultant spinel ferrites were employed in the synthesis of 14‐aryl‐14‐H‐dibenzo[a,j]xanthene derivatives. It was found that the nanocatalyst Cu0.5Co0.5Fe2O4 displays the best performance in the synthesis of 14‐aryl‐14H‐dibenzo[a,j]xanthenes. The catalyst was reused several times without significant loss of its activity for the preparation of desired product. In addition high yields of the products, solvent‐free conditions and reusability of the catalyst are other worthwhile advantages of the present study.
Syntheses, Structures and Anticancer Activity of NNO‐Tridentate Schiff Base Copper(II) Complexes
Authors: Lin Rong‐Kai , Hsu Cho‐Han , Chiu Chin‐I , Lai Ying‐Ju , Lai a Feng‐Jie , Chien Ching‐Ming , Lin Chu‐Chieh 
Published: September 2014

AbstractA series of heteroleptic copper(II) complexes [Cu(RQYMP)(Py]] (1a‐4d) supported on NNO‐tridentate Schiff base (RQYMP‐H) and bipyridine (Py=bpy, a; phen, b; dpq, c; dppz, d) co‐ligands have been synthesized and characterized. X‐ray crystal structural studies of complexes 1b, 2c, 3d and 4a displays that these complexes are mononuclear with a distorted square pyramidal geometry around the copper center. Cytotoxicity results indicate that all of these complexes have much higher activity against HeLa, SCC15, BCC and Ca9‐22 cancer cell lines as compared to cisplatin. Further, copper complex bearing suitable bulky group Schiff base ligands with dppz co‐ligand could be considered in designing efficient metalbased anticancer agents.
Synthesis and Structural Characterization of a Binuclear Mixed‐Ligand (Salicylate and N,N‐diethylnicotinamide) Nickel(II) Complex, Its Magnetic Properties. [Ni2(µ‐Sal)4(Dena)2]H2O
Authors: Köse Dursun Ali , Akkurt Fatih , Şahin Onur , Büyükgüngör Orhan 
Published: September 2014

AbstractThe title complex of [Ni2(µ‐Sal)4(Dena)2]H2O, [(µ‐tetrakissalicylato‐κ‐O,O)(bis‐N,N‐diethylnicotinamide‐κ‐N)(binickel(II))]hydrate, C48H52Ni2N4O16, has been synthesized and explained as structural using some elemental analysis, FT‐IR spectra, UV‐Vis reflectance, magnetic measurements, thermal analysis and x‐ray diffraction methods. The analysis results showed that the unit cell of complex includes two molecules NiII cation, four molecules salicylates as bridge and two molecules N,N‐diethylnicotinamide ligands, also there is one molecule hydrated aqua. The compound crystallizes in the monoclinic space group P21/c with the following unit‐cell parameters: a=13.6776(6) Å, b=10.5238(3) Å, c=21.8165(9), α=90.00°, β=126.546(3)°, γ=90.00º and Z=2. The compound [Ni2(µ‐Sal)4(Dena)2]H2O is a typical paddle‐wheel complex structure. Two NiII ions are bridged by four salicylate ligands (O2, O2i, O3, O3i, O5, O5i, O6 and O6i) using a µ‐COO− coordination mode [symmetry code: (i) 1‐x, 1‐y, 1‐z]. Each NiII also coordinates to one nitrogen atom (N1 and N1i) from one N,N‐diethylnicotinamide ligand molecule in the axial position. The complex has strong paramagnetic properties.
pRb2/p130 Localizes to the Cytoplasm in Diffuse Gastric Cancer
Authors: Cito Letizia , Indovina Paola , Forte Iris Maria , Pentimalli Francesca , Di Marzo Domenico , Somma Pasquale , Barone Daniela , Penon Antonella , Penon Danila , Ceccherini Elisa , Micheli Pietro , Saragoni Luca , Di Domenico Marina , Feola Antonia , Roviello Franco , Mattioli Eliseo , Giordano Giovan Giacomo , Giordano Antonio 
Published: September 2014

AbstractpRb2/p130 is a key tumor suppressor, whose oncosuppressive activity has mainly been attributed to its ability to negatively regulate cell cycle by interacting with the E2F4 and E2F5 transcription factors. Indeed, pRb2/p130 has been found altered in various cancer types in which it functions as a valuable prognostic marker. Here, we analyzed pRb2/p130 expression in gastric cancer tissue samples of diffuse histotype, in comparison with their normal counterparts. We found a cytoplasmic localization of pRb2/p130 in cancer tissue samples, whereas, in normal counterparts, we observed the expected nuclear localization. pRb2/p130 cytoplasmic delocalization can lead to cell cycle deregulation, but considering the emerging involvement of pRb2/p130 in other key cellular processes, it could contribute to gastric tumorigenesis also through other mechanisms. Our data support the necessity of further investigations to verify the possibility of using pRb2/p130 as a biomarker or potential therapeutic target for diffuse gastric cancer. J. Cell. Physiol. 230: 802–805, 2015. © 2014 Wiley Periodicals, Inc.
Gene Expression Changes in Progression of Cervical Neoplasia Revealed by Microarray Analysis of Cervical Neoplastic Keratinocytes
Authors: Rotondo John Charles , Bosi Silvia , Bassi Cristian , Ferracin Manuela , Lanza Giovanni , Gafà Roberta , Magri Eros , Selvatici Rita , Torresani Stefania , Marci Roberto , Garutti Paola , Negrini Massimo , Tognon Mauro , Martini Fernanda 
Published: September 2014

AbstractTo evaluate the gene expression changes involved in neoplastic progression of cervical intraepithelial neoplasia. Using microarray analysis, large‐scale gene expression profile was carried out on HPV16‐CIN2, HPV16‐CIN3, and normal cervical keratinocytes derived from two HPV16‐CIN2, two HPV‐CIN3 lesions, and two corresponding normal cervical tissues, respectively. Differentially expressed genes were analyzed in normal cervical keratinocytes compared with HPV16‐CIN2 keratinocytes and in HPV16‐CIN2 keratinocytes compared with HPV16‐CIN3 keratinocytes; 37 candidate genes with continuously increasing or decreasing expression during CIN progression were identified. One of these genes, phosphoglycerate dehydrogenase, was chosen for further characterization. Quantitative reverse transcription‐polymerase chain reaction and immunohistochemical analysis confirmed that expression of phosphoglycerate dehydrogenase consistently increases during progression of CIN toward cancer. Gene expression changes occurring during CIN progression were investigated using microarray analysis, for the first time, in CIN2 and CIN3 keratinocytes naturally infected with HPV16. Phosphoglycerate dehydrogenase is likely to be associated with tumorigenesis and may be a potential prognostic marker for CIN progression. J. Cell. Physiol. 230: 806–812, 2015. © 2014 Wiley Periodicals, Inc.
Assessing Computer Network Efficiency Using Data Envelopment Analysis and Multicriteria Decision Analysis Techniques
Authors: Ploskas Nikolaos , Stiakakis Emmanouil , Fouliras Panayotis 
Published: September 2014

AbstractMeasuring computer network efficiency is of great importance for a network manager. When a detailed picture of the current state of the network is available, we can use analytical and simulated‐based methods. Instead, it is more difficult to measure network efficiency, when the details of network topologies and internal characteristics are not available. In this paper, we present operations research techniques, which have been used in measuring the efficiency of economic systems, namely data envelopment analysis (DEA), stochastic frontier analysis (SFA) and preference ranking organization method for enrichment evaluations (PROMETHEE). We investigate whether these techniques can be used to assess network efficiency and provide the network manager with a complete set of quantitative suggestions towards relative efficiency improvement of the networks determined as inefficient. The average efficiencies extracted in our benchmark from DEA and SFA are almost equal. Furthermore, the decision maker can adjust the weights of the criteria in PROMETHEE in order to build different scenarios. Consequently, we claim that these methods can be used for measuring computer network efficiency, when networks' internal characteristics are not available. Copyright © 2014 John Wiley & Sons, Ltd.
Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity
Authors: Kim Yun‐Ji , Kim Jong‐Sang , Seo Young Rok , Park Jung Han Yoon , Choi Myung‐Sook , Sung Mi‐Kyung 
Published: September 2014

ScopeThis study determined the efficacy of carnosic acid (CA) for suppressing colon carcinogenesis associated with excess adiposity.Methods and resultsCell growth regulation by CA was evaluated in HT‐29 colon adenocarcinoma cells cocultured with 3T3‐L1 adipocytes. To determine the in vivo efficacies, male A/J mice were divided into four groups and fed one of the following experimental diets for 11 wk: 15% fat, 45% fat, 45% fat + 0.01% CA, or 45% fat + 0.02% CA. Azoxymethane was administered at the beginning of experimental diet and two cycles of dextran sodium sulfate were supplied 1 wk after the azoxymethane injection. The proliferation of HT‐29 cells cocultured with 3T3‐L1 cells was significantly higher than proliferation of control cells (p < 0.05). CA treatment suppressed the growth of cocultured HT‐29 cells through cell cycle arrest and enhanced apoptosis by inhibiting leptin receptor (Ob‐R) signaling, including Akt and extracellular signal‐regulated kinase (ERK) phosphorylation. CA supplementation in vivo decreased the number of colon tumors and reduced circulating concentrations of leptin, adiponectin, insulin, and insulin‐like growth factor 1. Colonic expression of Ob‐R, insulin receptor (IR), p‐Akt, p‐ERK, B‐cell lymphoma extra large (Bcl‐xL), and cyclinD1 protein was also suppressed in animals fed CA.ConclusionCA appears to alleviate adipocity‐related acceleration of colon tumor formation.
Non‐contrast‐enhanced peripheral angiography using a sliding interleaved cylinder acquisition
Authors: Kwon Kie Tae , Kerr Adam B. , Wu Holden H. , Hu Bob S. , Brittain Jean H. , Nishimura Dwight G. 
Published: September 2014

PurposeTo develop a new sequence for non‐contrast‐enhanced peripheral angiography using a sliding interleaved cylinder (SLINCYL) acquisition.MethodsA venous saturation pulse was incorporated into a three‐dimensional magnetization‐prepared balanced steady‐state free precession sequence for non‐contrast‐enhanced peripheral angiography to improve artery‐vein contrast. The SLINCYL acquisition, which consists of a series of overlapped thin slabs for volumetric coverage similar to the original sliding interleaved ky (SLINKY) acquisition, was used to evenly distribute the venous‐suppression effects over the field of view. In addition, the thin‐slab‐scan nature of SLINCYL and the centric‐ordered sampling geometry of its readout trajectory were exploited to implement efficient fluid‐suppression and parallel imaging schemes. The sequence was tested in healthy subjects and a patient.ResultsCompared to a multiple overlapped thin slab acquisition, both SLINKY and SLINCYL suppressed the venetian blind artifacts and provided similar artery‐vein contrast. However, SLINCYL achieved this with shorter scan times and less noticeable artifacts from k‐space amplitude modulation than SLINKY. The fluid‐suppression and parallel imaging schemes were also validated. A patient study using the SLINCYL‐based sequence well identified stenoses at the superficial femoral arteries, which were also confirmed with digital subtraction angiography.ConclusionNon‐contrast‐enhanced angiography using SLINCYL can provide angiograms with improved artery‐vein contrast in the lower extremities. Magn Reson Med 74:727–738, 2015. © 2014 Wiley Periodicals, Inc.
Uniform investigation of hydraulic fracturing propagation regimes in the plane strain model
Authors: Bao J.Q. , Fathi E. , Ameri S. 
Published: September 2014

SummaryThe hydraulic fracturing propagation regimes in the plane strain model are uniformly investigated using a numerical method based on the finite element method. The regimes range from toughness‐dominated cases to viscosity‐dominated cases, covering zero leak‐off situations and small leak‐off situations. Unlike the asymptotic solutions, the numerical method is independent of the energy dissipation regimes and fluid storage regimes. The numerical method pays no special attention to the fracture tip, and it simulates fracture tip behaviors by increasing the number of functions in a natural and uniform manner. The numerical method is verified by comparing its results with the asymptotic solutions. The effect of the model sizes on the numerical method is discussed along with the robustness of the numerical method. Copyright © 2014 John Wiley & Sons, Ltd.
Measurement of factors that negatively influence the outcome of quitting smoking among patients with COPD: psychometric analyses of the Try To Quit Smoking instrument
Authors: Lundh Lena , Alinaghizadeh Hassan , Törnkvist Lena , Gilljam Hans , Galanti Maria Rosaria 
Published: September 2014

AbstractAimsTo test internal consistency and factor structure of a brief instrument called Trying to Quit smoking.BackgroundThe most effective treatment for patients with chronic obstructive pulmonary disease is to quit smoking. Constant thoughts about quitting and repeated quit attempts can generate destructive feelings and make it more difficult to quit.DesignDevelopment and psychometric testing of the Trying to Quit smoking scale.MethodsThe Trying to Quit smoking, an instrument designed to assess pressure‐filled states of mind and corresponding pressure‐relief strategies, was tested among 63 Swedish patients with chronic obstructive pulmonary disease. Among these, the psychometric properties of the instrument were analysed by Exploratory Factor Analyses.ResultsFourteen items were included in the factor analyses, loading on three factors labelled: (1) development of pressure‐filled mental states; (2) use of destructive pressure‐relief strategies; and (3) ambivalent thoughts when trying to quit smoking. These three factors accounted for more than 80% of the variance, performed well on the Kaiser‐Meyer‐Olkin (KMO) test and had high internal consistency.
Prenatal diagnosis and perinatal outcome of congenital dacryocystocele: a large case series
Authors: Li Sheng‐li , Luo Guo‐yang , Tian Xiao‐xian , Yu Rong , Norwitz Errol R. , Qin Feng‐zhen , Wen Hua‐xuan , Bi Jing‐ru , Lin Xiao‐ying , Zhong Xiao‐hong 
Published: September 2014

AbstractObjectiveTo describe the incidence, prenatal diagnosis, and perinatal outcome in fetuses with congenital dacryocystocele.MethodsAll cases of congenital dacryocystocele diagnosed by prenatal ultrasound were identified using an established perinatal database. Prenatal ultrasound images were reviewed, and perinatal outcome was abstracted from the medical records. The correlation between the cyst size, gestational age, and prenatal and neonatal outcome was analyzed.ResultsThe overall incidence of fetal dacryocystocele was 0.016% (75/456,202). Fifty‐three cases (70.7%) had unilateral, and 22 (29.3%) had bilateral lesions. Lesions were seen more commonly among female fetuses with a female : male ratio 1.48 : 1. The average diameter of cysts size was 6.9 ± 1.9 mm (3.3–11 mm). There was a direct correlation between cyst size and gestational age. Among the 75 cases, 8 were lost to follow‐up, 3 underwent elective termination of pregnancy. 58 resolved spontaneously before birth, and 6 were confirmed at birth. Two developed neonatal infection requiring antibiotic treatment. All 6 cases confirmed at birth resolved without surgical resection.ConclusionsCongenital dacryocystocele can be diagnosed by prenatal ultrasound. Such lesions typically resolve spontaneously in utero or in the early neonatal period. Thus, it should be considered as a developmental variant rather than a structural birth defect. © 2014 John Wiley & Sons, Ltd.
Analysis and performance evaluation of new coding options for space telecommand links ‐ Part I: AWGN channels
Authors: Baldi M. , Chiaraluce F. , Garello R. , Maturo N. , Aguilar Sanchez I. , Cioni S. 
Published: September 2014

SummaryWe investigate and compare, over the additive white Gaussian noise channel, different options for updating the error correcting code currently used in space mission telecommand links. Besides some more consolidated proposals, using low‐density parity‐check codes, we characterize and assess the performance of alternative schemes, based on parallel turbo codes and soft‐decision decoded Bose‐Chaudhuri‐Hocquenghem (BCH) codes. The analysis considers relevant metrics like the codeword error rate, the frame error rate, and the undetected frame error rate. The considered codes include binary and non‐binary low‐density parity‐check codes, parallel turbo codes and extended BCH codes, with different decoding algorithms. The complexity of the various schemes and possible limits for their application are considered and discussed. Several numerical examples are provided. International Journal of Satellite Communications and Networking. Copyright © 2014 John Wiley & Sons, Ltd.
A practical strongly secure one‐round authenticated key exchange protocol without random oracles
Authors: Yang Zheng , Yang Wu 
Published: September 2014

AbstractMost recently, a variant of extended Canetti–Krawczyk model called as eCKw is introduced to provide stronger security than previous eCK models. Namely eCKw models formulate a stronger notion regarding weak perfect forward secrecy than other eCK models. In particular, any eCKw secure protocols can be generally transformed to achieve full provide perfect forward secrecy without requiring additional round. So far, there is no protocol which has been proven secure in the eCKw model without random oracles. In this paper, we study the open problem on constructing eCKw secure AKE protocol in the standard model. A new one‐round AKE protocol is introduced relying on standard cryptographic primitives and a variant of bilinear decisional Diffie–Hellman assumption. The main advantage of our proposal is its high efficiency in key exchange in contrast to the previous eCK secure protocols without random oracles and under post‐specified peer setting. Copyright © 2014 John Wiley & Sons, Ltd.
On the security of Kim et al. two ID‐based broadcast signcryption schemes
Authors: Zhang Jianhong , Tang Wenjing 
Published: September 2014

AbstractAs a combination of broadcast encryption and signcryption, broadcast signcryption enables a broadcaster to simultaneously achieve encryption and signature for a specific set of receivers in a single logical step. And it can provide a very efficient solution to achieve confidentiality and authentication of message source during information distribution. Recently, to achieve both confidentiality and authenticity simultaneously, Kim et al. proposed two source‐authenticated broadcast encryption schemes and claimed that their two schemes could provide both authentication and confidentiality simultaneously. Despite being proven to secure, their schemes are shown to be insecure in this paper, namely, they cannot achieve authentication and confidentiality of message. An attacker can forge a ciphertext and convince a specified receiver that the ciphertext is from a valid broadcaster. 3 After the corresponding attacks are given, the reasons to produce such attacks are analyzed at last. Copyright © 2014 John Wiley & Sons, Ltd.
Pelvic insufficiency: a deeper look at female and male gonadal vein incompetence
Authors: Allcorn Tamara 
Published: September 2014

AbstractInsufficiency within the pelvic veins although a proven clinical entity, is not commonly assessed and is often overlooked and underdiagnosed in women. Insufficiency of the pelvic veins, otherwise known as pelvic congestion syndrome in women, and varicocele in men, can be the cause of increased pain and discomfort for the patient. Insufficiency within the gonadal veins can, when prolonged, lead to an increase in varicose veins within the lower extremities, or in the instance of a patient who has already undergone surgery, these veins may be a strong contributor to recurrence rates. By comparing the similarities between male and female insufficiency, a standardised and more common practice of diagnosing female insufficiency should be implemented. The overall treatment and outcome for the patient, not to mention the long term benefits, especially if leg varicosities are involved as well, will be significantly improved if this condition is diagnosed correctly.
NTPDase2 and Purinergic Signaling Control Progenitor Cell Proliferation in Neurogenic Niches of the Adult Mouse Brain
Authors: Gampe Kristine , Stefani Jennifer , Hammer Klaus , Brendel Peter , Pötzsch Alexandra , Enikolopov Grigori , Enjyoji Keiichi , Acker-Palmer Amparo , Robson Simon C. , Zimmermann Herbert 
Published: September 2014

Abstract
Nerve cells are continuously generated from stem cells in the adult mammalian subventricular zone (SVZ) and hippocampal dentate gyrus. We have previously noted that stem/progenitor cells in the SVZ and the subgranular layer (SGL) of the dentate gyrus express high levels of plasma membrane-bound nucleoside triphosphate diphosphohydrolase 2 (NTPDase2), an ectoenzyme that hydrolyzes extracellular nucleoside diphosphates and triphosphates. We inferred that deletion of NTPDase2 would increase local extracellular nucleoside triphosphate concentrations perturbing purinergic signaling and boosting progenitor cell proliferation and neurogenesis. Using newly generated mice globally null for Entpd2, we demonstrate that NTPDase2 is the major ectonucleotidase in these progenitor cell-rich areas. Using BrdU-labeling protocols, we have measured stem cell proliferation and determined long-term survival of cell progeny under basal conditions. Brains of Entpd2 null mice revealed increased progenitor cell proliferation in both the SVZ and the SGL. However, this occurred without noteworthy alterations in long-term progeny survival. The hippocampal stem cell pool and the pool of the intermediate progenitor type-2 cells clearly expanded. However, substantive proportions of these proliferating cells were lost during expansion at around type-3 stage. Cell loss was paralleled by decreases in cAMP response element-binding protein phosphorylation in the doublecortin-positive progenitor cell population and by an increase in labeling for activated caspase-3 levels. We propose that NTPDase2 has functionality in scavenging mitogenic extracellular nucleoside triphosphates in neurogenic niches of the adult brain, thereby acting as a homeostatic regulator of nucleotide-mediated neural progenitor cell proliferation and expansion. Stem Cells 2015;33:253–264