bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐inferiority of silodosin 4 mg once daily to twice daily for storage symptoms score evaluated by the International Prostate Symptom Score in Japanese patients with benign prostatic hyperplasia: A multicenter, randomized, parallel‐group study
Authors: Seki Narihito , Takahashi Ryosuke , Yamaguchi Akito , Ito Kenji , Takayama Kazuo , Nanri Kazushige , Kamiryo Yoriaki , Yamashita Hiroshi , Komine Shinichiro , Miyazaki Yoshiharu , Uozumi Jiro , Naito Seiji 
Published: January 2015

ObjectivesTo compare the effect of treatment with silodosin 4 mg once daily versus that of silodosin 4 mg twice daily on storage symptoms in Japanese patients with benign prostatic hyperplasia.MethodsA prospective, multicenter, 12‐week, open‐labeled study randomized a total of 268 men aged 50 years or older with benign prostatic hyperplasia and overactive bladder to silodosin 4 mg/day or 8 mg/day. Changes in the end‐points of the average value of International Prostate Symptom Score, quality of life index in the International Prostate Symptom Score, Overactive Bladder Symptom Score and urodynamic parameters were evaluated. The change in the storage symptom subtotal score of the International Prostate Symptom Score was considered as the primary end‐point.ResultsSilodosin 4 mg/day was not inferior to silodosin 8 mg/day in regard to the primary end‐point. In contrast, the efficacy of treatment with silodosin 4 mg twice daily was greater than that of 4 mg once daily, based on both the quality of life index and the Overactive Bladder Symptom Score total score. There was a discrepancy between the scores evaluated using the International Prostate Symptom Score and Overactive Bladder Symptom Score questionnaires.ConclusionsSilodosin 4 mg once daily is not inferior to silodosin 4 mg twice daily in regard to storage symptoms score evaluated by the International Prostate Symptom Score. In contrast, silodosin 4 mg twice daily is more effective on storage symptoms evaluated by the Overactive Bladder Symptom Score than silodosin 4 mg once daily.
Impact of a Chronic Total Occlusion in an Infarct‐Related Artery on the Long‐Term Outcome of Ventricular Tachycardia Ablation
Authors: DI MARCO ANDREA , PAGLINO GABRIELE , OLORIZ TERESA , MACCABELLI GIUSEPPE , BARATTO FRANCESCA , VERGARA PASQUALE , BISCEGLIA CATERINA , ANGUERA IGNASI , SALA SIMONE , SORA NICOLETA , DALLAGLIO PAOLO , MARZI ALESSANDRA , TREVISI NICOLA , MAZZONE PATRIZIO , DELLA BELLA PAOLO 
Published: January 2015

IRA‐CTO and VT AblationIntroductionIn patients with a prior myocardial infarction (MI), angiographic predictors of ventricular tachycardia (VT) recurrence after ablation are lacking. Recently, a proarrhythmic effect of a chronic total occlusion (CTO) in a coronary artery has been suggested.Methods and ResultsA total of 191 patients with prior MI were referred to our Hospital between 2010 and June 2013 for a first ablation of VT. Of these, 84 patients (44%) with stable coronary artery disease that underwent a coronary angiography during the index hospitalization were included in this study. A CTO in an infarct‐related artery (IRA‐CTO) was present in 47 patients (56%). Patients with and without IRA‐CTO did not differ in terms of comorbidities, severity of heart failure, presentation of VT or acute outcome of ablation, that was completely successful in 93% of cases. At electroanatomic mapping, IRA‐CTO was associated with greater scar and especially with greater area of border zone (34 cm2 vs. 19 cm2, P = 0.001). Median follow‐up was 19 months (IQR 18). At follow‐up, patients with IRA‐CTO had a significantly higher rate of VT recurrence (47% vs. 16%, P = 0.003). At multivariate analysis, IRA‐CTO resulted to be an independent predictor of VT recurrence after ablation (HR 4.05, P = 0.004).ConclusionsIRA‐CTO is an independent predictor of VT recurrence after ablation and identifies a subgroup of patients with high recurrence rate despite a successful procedure. IRA‐CTO is associated with greater scars and border zone area; however, this association does not completely justify its proarrhythmic effect.
Flooding with constraints: water meadow irrigation impacts on temperature, oxygen, phosphorus and sediment in water returned to a river
Authors: Cook H.F. , Cutting R.L. , Valsami‐Jones E. 
Published: January 2015

AbstractWater meadows are pasture irrigation systems found across Europe. They potentially mitigate local flooding where a thin sheet of water is allowed across an engineered floodplain surface. In southern England, functioning ‘bedwork’ systems require investigation for their impact on water returned to a river in terms of temperature, dissolved oxygen, sediment trapping and the transport of phosphorus. Temperature change in water returned to the river is found to be minimal, and it remains well oxygenated. Water meadow systems reduce %silt in deposited sediment by an average of 14% and reduce mobile phosphorus by around one third. Soils show a decline in plant‐available phosphorus by one half. Evaluation of the impact on rivers is important because water meadows are typically managed under agri‐environmental schemes, and there is realisation of their historically demonstrated potential for floodwater retention.
Involving relatives in ICU patient care: critical care nursing challenges
Authors: McConnell Bridget , Moroney Tracey 
Published: January 2015

Aims and objectivesTo identify the barriers critical care nurses experience to relative involvement in intensive care unit patient care.BackgroundPrevious studies have discussed the experiences of relatives visiting an intensive care unit, the needs of relatives in the intensive care environment, critical care nurse and relative interaction, intensive care unit visiting policies and the benefits of including relatives in patient care. The barriers that critical care nurses experience to relative involvement in patient care have received minimal exploration.DesignCritical care nurses were recruited for a mixed methods study. An explanatory mixed method design was used, with two phases. Phase 1 was Quantitative and Phase 2 was Qualitative.MethodsData collection occurred over five months in 2012–2013. Phase 1 used an online questionnaire (n = 70), and semi‐structured interviews (n = 6) were conducted in Phase 2. Phase 1 participants were 70 critical care nurses working in Australian intensive care units and six critical care nurses were recruited from a single Sydney intensive care unit for Phase 2. Through sequential data collection, Phase 1 results formed the development of Phase 2 interview questions.ResultsParticipants reported various barriers to relative involvement in critically ill patient care. Factors related to the intensive care unit patient, the intensive care unit relative, the critical care nurse and the intensive care environment contributed to difficulties encompassing relative involvement.ConclusionsThis study has identified that when considering relative involvement in patient care, critical care nurses take on a paternalistic role. The barriers experienced to relative involvement result in the individual critical care nurse deciding to include or exclude relatives from patient care.Relevance to clinical practiceKnowledge of the barriers to relative involvement in critically ill patient care may provide a basis for improving discussion on this topic and may assist intensive care units to implement strategies to reduce barriers.
ZmpTAC12 binds single‐stranded nucleic acids and is essential for accumulation of the plastid‐encoded polymerase complex in maize
Authors: Pfalz Jeannette , Holtzegel Ute , Barkan Alice , Weisheit Wolfram , Mittag Maria , Pfannschmidt Thomas 
Published: January 2015

Summary

The plastid‐encoded plastid RNA polymerase (PEP) represents the major transcription machinery in mature chloroplasts. Proteomic studies identified four plastome‐ and at least ten nuclear‐encoded proteins making up this multimeric enzyme. Depletion of single subunits is known to result in strongly diminished PEP activity causing severe defects in chloroplast biogenesis.

Here, we characterized one PEP subunit in maize, ZmpTAC12, and investigated the molecular basis underlying PEP‐deficiency in Zmptac12 mutants.

We show that the ZmpTAC12 gene encodes two different protein isoforms, both of which localize dually in chloroplasts and nuclei. Moreover, both variants assemble into the PEP‐complex. Analysis of PEP‐complex assembly in various maize mutants lacking different PEP‐complex components demonstrates that ZmpTAC12, ZmpTAC2, ZmpTAC10 and ZmMurE are each required to accumulate a fully assembled PEP‐complex. Antibodies to ZmpTAC12 coimmunoprecipitate a subset of plastid RNAs that are synthesized by PEP‐dependent transcription. Gel mobility shift analyses with recombinant ZmpTAC12 revealed binding capabilities with ssRNA and ssDNA, but not dsDNA.

Collectively these data demonstrate that ZmpTAC12 is required for the proper build‐up of the PEP‐complex and that it interacts with single‐stranded nucleic acids.
Wheat allergy in children evaluated with challenge and IgE antibodies to wheat components
Authors: Nilsson Nora , Sjölander Sigrid , Baar Alexandra , Berthold Malin , Pahr Sandra , Vrtala Susanne , Valenta Rudolf , Morita Eishin , Hedlin Gunilla , Borres Magnus P. , Nilsson Caroline 
Published: January 2015

AbstractIntroductionWheat sensitization is common but IgE antibodies (IgE‐abs) to wheat are not predictive of clinical symptoms in children with suspected wheat allergy. Wheat allergen components other than ω‐5 gliadin have not been well studied. Our aim was to characterize the clinical profile and investigate the value of adding measurements of IgE‐abs to wheat components in a group of children with a doctor's diagnosed wheat allergy.MethodSixty‐three children with a doctor's diagnosis of wheat allergy confirmed sensitization to wheat and, on a wheat elimination diet, went through oral wheat challenges or had a convincing recent history of wheat allergy. IgE‐ab to ω‐5 gliadin, low molecular weight glutenin (LMW‐glutenin), high molecular weight glutenin (HMW‐glutenin) and a native gliadin preparation containing α‐, β‐, γ‐, and ω‐gliadin (gliadin) were analyzed.ResultsTwenty‐six children were positive in challenge, while six children were regarded as wheat allergic due to recent anaphylactic reactions. The IgE‐ab levels to all four wheat components were significantly higher in the group with wheat allergy compared to the group with no wheat allergy (p < 0.0001). Also, the severity of symptoms at challenge correlated with the IgE‐ab levels to all four components (p < 0.05). IgE‐ab levels to ω‐5 gliadin correlated best with challenge outcome, and by additional analysis of gliadin, HMW‐ and LMW‐glutenin IgE‐abs all challenge positive children could be identified.ConclusionMany children diagnosed as wheat allergic have outgrown their allergy and are unnecessarily on a wheat‐free diet. The levels of IgE‐ab to wheat gluten‐derived components correlated well with wheat challenge outcome and severity.
Childhood asthma is associated with polymorphic markers of PROC on 2q14 in addition to 17q21 locus
Authors: Chan Wa Cheong , Sy Hing Yee , Kong Alice P.‐S. , Wong Chun K. , Tse Lai Yin , Hon Kam Lun , Chan Juliana C.‐N. , Wong Gary W.‐K. , Leung Ting Fan 
Published: January 2015

AbstractBackgroundChildhood asthma is caused by both genetic and environmental factors. The first genomewide association study (GWAS) for asthma revealed putative candidates on nine chromosomal regions in Caucasians, with 17q21 locus being the most widely replicated one. However, there was no replication study for the other loci. This study investigated genetic associations between childhood asthma and autosomal single nucleotide polymorphisms (SNPs) on eight loci reported in the first GWAS among Hong Kong Chinese.Methods510 asthmatic children and 510 non‐allergic controls were recruited. 110 tagging SNPs selected based on r2 ≥ 0.80 and minor allele frequency ≥0.05 for Han Chinese among all SNPs located 50‐kb upstream and downstream of significant autosomal SNPs were genotyped by TaqMan allelic discrimination assays. Transcription factor binding of SNPs was determined by electrophoretic mobility shift assay (EMSA).ResultsAsthma was significantly associated with SNPs on 17q21 and 2q14 loci. Twelve SNPs on 17q21 were associated with asthma, with rs6503527 being the most significant SNP. Five SNPs of protein C gene (PROC) on 2q14 were associated with asthma, with rs6755028 being the most significant SNP. Plasma protein C concentrations were higher in asthmatic patients than controls, and five PROC SNPs were associated with plasma protein C concentrations. EMSA showed specific differential binding of rs878461 to nuclear extracts from bronchial epithelial and hepatocarcinoma cell lines.ConclusionsOur findings identify PROC on 2q14 as a novel candidate for childhood asthma and replicate the genetic association for 17q21 locus. Rs878461 of PROC may increase asthma susceptibility by altering transcription factor binding.
Technique advance to avoid hepatic venous outflow obstruction in pediatric living‐donor liver transplantation
Authors: Tannuri Uenis , Tannuri Ana Cristina A. , Santos Maria M. , Miyatani Helena T. 
Published: January 2015

AbstractHVOO represents a serious critical complication of pediatric living‐donor liver transplantation because open surgical repair is virtually impossible. Currently, despite several technical innovations and the introduction of triangulated anastomosis for hepatic vein reconstruction, the reported incidence of HVOO is still considerable. The aim of this study was to propose a new technique for hepatic venous reconstruction that avoids the original orifice of the recipient hepatic veins. Instead, anastomosis is performed in a newly created wide longitudinal orifice in the anterior wall of the recipient inferior vena cava. A total of 210 living related‐donor liver transplantations were performed using two methods for reconstruction of the hepatic vein. Group 1 included 69 patients subjected to direct anastomosis of the orifice of the graft hepatic vein and a wide orifice created in the recipient inferior vena cava by the confluence of the orifices of the right, left, and middle hepatic veins. Group 2 included 141 patients in whom the original orifices of the recipient hepatic veins were closed, the inferior vena cava was widely opened, and a long longitudinal anastomosis was performed using two lines of continuous sutures. Diagnosis of HVOO was suspected based on clinical findings and ultrasound studies and then confirmed by liver biopsy and interventional radiology examinations. Among the 69 recipients in group 1, 16 patients died due to graft problems during the postoperative period and eight of the survivors (15.1%) presented with HVOO. In group 2 (141 patients), 21 patients died, and there were no cases of HVOO. A comparison of the incidence of HVOO between groups revealed a significant difference (p = 0.01). Hepatic venous reconstruction during pediatric living‐donor liver transplantation should be performed using a wide longitudinal incision in the anterior wall of the recipient inferior vena cava because this technique eliminated anastomosis complications.
Evaluation of light‐emitting diodes (LED) effect on skin biology (in vitro study)
Authors: Chabert R. , Fouque L. , Pinacolo S. , Garcia‐Gimenez N. , Bonnans M. , Cucumel K. , Domloge N. 
Published: January 2015

BackgroundInterest in anti‐aging approaches has grown significantly in recent years. The most popular are the non invasive methods to decrease the signs of aging. One such method is LED‐based therapy.MethodsThis study investigated the potential of two different wavelengths, 590 nm and 630 nm, combined or not, in the photobiomodulation of proteins involved in the slowdown of the skin aging.ResultsThese in vitro results on cell viability, cell shape, and mitochondrial function support and build on previous studies suggested that LED treatment is safe. Regarding its biological functions, our data indicated that the combination of two different wavelengths acted in synergy to enhance the impact of each irradiation alone. Combined, the LED wavelengths could improve in vitro the cell shape, the cell proliferation, and the level of major proteins involved in the healing process.ConclusionThese benefits may lead to reinforcement of the skin organization and structure. This hypothesis will be checked in future clinical studies.
Validity of Pedometers to Measure Step Counts During Dance
Authors: Barreira Tiago V. , Bennett John P. , Kang Minsoo 
Published: January 2015

Purpose:To obtain validity evidence for the measurement of step counts by spring-levered and piezoelectric pedometers during dance.Methods:Thirty-five adults in a college dance class participated in this study. Participants completed trials of 3- and 5-min of different styles of dance wearing Walk4life MVP and Omron HJ-303 pedometers, while their steps were visually counted. Pearson correlation, paired t-test, mean absolute percent error (MAPE), and mean bias were calculated between actual step and pedometer step counts for the 3- and 5-min dances separately.Results:For the Walk4life trials the correlations were .92 and .77 for the 3- and 5-min dances. No significant differences were shown by t-test for the 3- (P = .16) and 5-min dances (P = .60). However, MAPE was high, 17.7 ± 17.7% and 19.4 ± 18.3% for the 2 dance durations, respectively. For the Omron, the correlations were .44 and .58 for the 3- and 5-min dances, respectively. No significant differences were shown by t-test for the 3-min (P = .38) and for the 5-min (P = .88) dances. However, MAPE was high, 19.3 ± 16.4% and 26.6 ± 15.2% for the 2 dance durations, respectively.Conclusions:This study demonstrated that pedometers can be used to estimate the number of steps taken by a group of college students while dancing, however caution is necessary with individual values.
The Efficacy of a Walking Intervention Using Social Media to Increase Physical Activity: A Randomized Trial
Authors: Rote Aubrianne E. , Klos Lori A. , Brondino Michael J. , Harley Amy E. , Swartz Ann M. 
Published: January 2015

Background:Facebook may be a useful tool to provide a social support group to encourage increases in physical activity. This study examines the efficacy of a Facebook social support group to increase steps/day in young women.Methods:Female college freshmen (N = 63) were randomized to one of two 8-week interventions: a Facebook Social Support Group (n = 32) or a Standard Walking Intervention (n = 31). Participants in both groups received weekly step goals and tracked steps/day with a pedometer. Women in the Facebook Social Support Group were also enrolled in a Facebook group and asked to post information about their steps/day and provide feedback to one another.Results:Women in both intervention arms significantly increased steps/day pre- to postintervention (F(8,425) = 94.43, P < .001). However, women in the Facebook Social Support Group increased steps/day significantly more (F(1,138) = 11.34, P < .001) than women in the Standard Walking Intervention, going from 5295 to 12,472 steps/day.Conclusions:These results demonstrate the potential effectiveness of using Facebook to offer a social support group to increase physical activity in young women. Women in the Facebook Social Support Group increased walking by approximately 1.5 miles/day more than women in the Standard Walking Intervention which, if maintained, could have a profound impact on their future health.
Feasibility and Preliminary Efficacy of the MADE4Life Program: A Pilot Randomized Controlled Trial
Authors: Barnes Alyce T. , Plotnikoff Ronald C. , Collins Clare E. , Morgan Philip J. 
Published: January 2015

Background:The aim was to assess the feasibility and preliminary efficacy of a community-based physical activity (PA) intervention targeting mothers and daughters.Methods:A randomized controlled trial of 48 primary school-aged girls and their 40 mothers were randomized to (i) Mothers And Daughters Exercising for Life (MADE4Life) (n = 21 mothers, n = 25 daughters) or (ii) wait-list control (n = 19 mothers, n = 23 daughters). The 8-week program involved 8 sessions; 25-minute separate mothers and daughters education sessions and 60-minutes PA together. Assessments were at baseline, postintervention and 3-month postintervention. Primary outcome measure was daughters’ moderateto-vigorous physical activity (MVPA) (accelerometer). Secondary outcomes included accelerometer-assessed light/moderate/vigorous PA, BMI, waist circumference, body composition, blood pressure, resting heart rate, sedentary behaviors and mothers’ self-reported PA, parenting measures, and cognitions. Intention-to-treat analysis used linear mixed models.Results:Recruitment and retention goals were exceeded. Attendance rates, program acceptability and satisfaction were high. There was no significant group-by-time effect for daughters’ %MVPA (–0.08; 95%CI –1.49, 1.33, d = –0.03) or other secondary outcomes for girls (postintervention range d = 0.01 to –0.46). Significant intervention effects were found for mothers’ %VPA (P = .04, d = 0.25) and role modeling (P = .02, d = 0.66).Conclusion:MADE4Life was both feasible and acceptable. Although very small effect sizes were found for the daughters, significant changes were seen for mothers (d = 0.25 to 0.66). Future fully powered trials targeting PA in mothers and daughters is warranted.
Tracking of Pedometer-Determined Physical Activity in Healthy Elderly Japanese People
Authors: Yamamoto Naofumi , Shimada Mieko , Nakagawa Naoki , Sawada Susumu S. , Nishimuta Mamoru , Kimura Yasuo , Ohashi Masaharu , Asai Hidenori , Miyazaki Hideo , Lee I-Min , Blair Steven N. , Yoshitake Yutaka 
Published: January 2015

Background:Tracking refers to the tendency for an individual to maintain their rank within a group over time. This study longitudinally investigated the 8-year tracking of pedometer-determined physical activity among physically independent elderly Japanese people aged 72 to 80 years.Methods:Steps/day were measured when participants were aged 72 and assessed again after 2, 5, and 8 years. The number of participants with a 2-year follow-up (72 to 74 years) was 177 (101 males, 76 females), with a 5-year follow-up (72 to 77 years) was 183 people (110 males, 73 females), and with an 8-year follow-up (72 to 80 years) was 145 people (91 males, 54 females). Step counts were continuously measured for 1 week in January, April, July, and October during each year of assessment.Results:A high rank correlation coefficient for steps/day exceeding 0.60 was obtained at the 2-, 5- and 8-year follow-up examinations for both males and females.Conclusion:This study suggests that the rank within a group of pedometer-determined steps/day remains stable over up to 8 years in healthy Japanese people aged between 72 to 80 years old.