bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameter optimization of intermittent demand forecasting by using spreadsheet
Authors: Ogcu Kaya Gamze , Demirel Omer Fahrettin 
Published: June 2015

Purpose
– Accurate forecasting of intermittent demand is very important since parts with intermittent demand characteristics are very common. The purpose of this paper is to bring an easier way of handling the hard work of intermittent demand forecasting by using commonly used Excel spreadsheet and also performing parameter optimization.

Design/methodology/approach
– Smoothing parameters of the forecasting methods are optimized dynamically by Excel Solver in order to achieve the best performance. Application is done on real data of Turkish Airlines’ spare parts comprising 262 weekly periods from January 2009 to December 2013. The data set are composed of 500 stock-keeping units, so there are 131,000 data points in total.

Findings
– From the results of implementation, it is shown that using the optimum parameter values yields better performance for each of the methods.

Research limitations/implications
– Although it is an intensive study, this research has some limitations. Since only real data are considered, this research is limited to the aviation industry.

Practical implications
– This study guides market players by explaining the features of intermittent demand. With the help of the study, decision makers dealing with intermittent demand are capable of applying specialized intermittent demand forecasting methods.

Originality/value
– The study brings simplicity to intermittent demand forecasting work by using commonly used spreadsheet software. The study is valuable for giving insights to market players dealing with items having intermittent demand characteristics, and it is one of the first study which is optimizing the smoothing parameters of the forecasting methods by using spreadsheet in the area of intermittent demand forecasting.
A hybrid decision-support model for self-managed career
Authors: Yildiz Didem , Beskese Ahmet , Bozbura Faik Tunc 
Published: June 2015

Purpose– The purpose of this paper is to develop a self-managed career model, in which protean and boundaryless careers were used.Design/methodology/approach– A hybrid methodology is proposed where Buckley’s fuzzy analytic hierarchy process (FAHP) method was used for prioritization of these criteria, sub-criteria, and indicators, and fuzzy TOPSIS method was used to select the most appropriate career path for a given individual.Findings– The hybrid model for self-managed career was tested with a real numerical example. Findings were congruent with the example’s current career and future career aspirations.Research limitations/implications– The model was tested with one numerical example. The model could be applied to individuals from various cultures, age groups and backgrounds to further discuss its validity.Originality/value– Career decisions are affected from individuals’ values and perceptions. New career orientations like Protean and Boundaryless Career are built upon this fact to include subjectivity. Because of the shortcomings of traditional methods to deal with uncertainty related to subjective evaluations, a FAHP and fuzzy TOPSIS based hybrid multi-attribute decision-support model was utilized to help individuals with their career decisions.
Detection and self-healing of cluster breakages in mines and tunnels: an empirical investigation
Authors: Khan Muhammad  Yousaf , Qaisar Saad B. , Naeem Muhammad , Aslam Awais , Shahid Saleem , Naqvi Ijaz 
Published: June 2015

Purpose
– The study aims at providing a reliable system of real-time monitoring for underground mine and tunnels which detects any structural change in the network and reconfigures it for resuming the data delivery process. In high stress environments, e.g. underground mines and tunnels, real-time activity monitoring is an emerging issue. Wireless sensor networks (WSNs) play a key role in ensuring the safety of people working in underground mines and tunnels. WSN not only provide real-time monitoring of underground environment but also detects any structural change in the network itself.

Design/methodology/approach
– In this paper, results of empirical implementation of a re-configurable WSN, capable of self-healing approach, reconfigure the network connectivity upon failure or addition of nodes in the system. An open-source radio-frequency identification standard for WSN, named as DASH7, is used for practical implementation. The proposed system is capable of determining cluster breakage by sudden disruptions caused by roof falls, explosions and node failures, sensor coverage hole, node re-addition to the network and distress priority signal generation by the miner.

Findings
– The proposed platform contributes to re-attain network state for establishing a communication link with fusion center in terms of: instant and accurate detection of collapse holes, acceptable error rate, time to re-attain network state, rapid distress signal propagation and low deployment cost. This platform is deployed in four different environments of anechoic chamber, hallway, outdoor and underground mine environment, to test the aforementioned scenarios using DASH7-compatible Bitsense Sensor Motes operating at 433 MHz. The effectiveness of the proposed approach has been experimentally validated for the single and multiple adjacent and disjoint node failures in all the four environments.

Originality/value
– The number of monitoring systems was implemented for safety assurance in high stress environments before, but the novelty of our platform is long range, cost effectiveness, quick response to any structural change in the network, rapid and accurate data delivery using WSN operated on DASH7 protocol stack.
Detecting explosives and chemical weapons: a review of recent developments
Authors: Bogue Robert 
Published: June 2015

Purpose
– The purpose of this paper is to provide details of recent developments in sensors for detecting explosives and chemical warfare agents.

Design/methodology/approach
– Following an introduction, this paper first discusses a selection of new sensing techniques aimed at detecting explosives and explosive devices. It then considers new developments in sensors for detecting chemical warfare agents. Brief concluding comments are drawn.

Findings
– This paper shows that a diversity of sensor technologies is being investigated, including various advanced optical methods, nanomaterials, microelectromechanical system, electronic noses, biosensors and electrochemical techniques, several of which offer levels of sensitivity in the parts-per-trillion region. These not only have the potential to yield improved devices for detecting explosives and chemical weapons but may also play a role in health care, environmental monitoring, drug detection and industrial health and safety.

Originality/value
– In an era of escalating terrorism and military conflicts, this provides a timely review of new technologies for detecting explosives and chemical warfare agents.
Interactive flood hazard visualisation in Adobe Flash
Authors: Coller M.L.F. , Wheeler P. , Kunapo J. , Peterson J. 
Published: June 2015

AbstractAdvances in analytical flood modelling need to be accompanied by similar advances in the means by which model results can be disseminated across a wide range of stakeholder groups. In this paper, we exemplify the use of Adobe Flash as a means to design interactive flood mapping methods that can portray a wide range of potential flood levels, and place them into a context of flood frequency. We apply this methodology to a coastal flood‐prone locality in Australia, integrating a range of flood‐related information into a single intuitive interface. We demonstrate how a temporal dimension can be incorporated to represent future changes to inundation probability based on climate change projections of sea‐level rise. The resulting visualisation is accessible directly via the web, and is designed for ease of use and understanding for all stakeholders. Such flexible methods of representing flood hazard can foster education on flood issues, support community decision‐making and assist emergency response when floods eventuate. In this way, such mapping methods can play a vital role in integrated coastal zone management initiatives.
Persistent Bacillus Calmette–Guerin Reaction: A Potential Clue to Underlying Immune Deficiency
Authors: Khalsa Amrit , Rubin Adam I. , Jen Melinda 
Published: June 2015

AbstractBacillus Calmette–Guerin (BCG) vaccine complications in patients with severe combined immunodeficiency (SCID) have been well documented in the literature. We present a case in which the BCG vaccine was administered to an infant who was later diagnosed with SCID and presented with worsening localized BCG reaction upon arrival in the United States. Although the BCG vaccine is not routinely administered in the United States, it is important for physicians to be aware of potential complications of BCG vaccination since prompt treatment can be lifesaving.
Hormone signalling pathways are differentially involved in quantitative resistance of potato to Phytophthora infestans
Authors: Saubeau G. , Perrin F. , Marnet N. , Andrivon D. , Val F. 
Published: June 2015

Quantitative resistance may depend on the effectiveness of PAMP‐triggered immunity. This study highlights the diversity of mechanisms involved in the quantitative resistance of potato to Phytophthora infestans. The investigation focused on the implication of the hormone signalling pathways induced in four potato genotypes by a concentrated culture filtrate (CCF) of P. infestans. The genotypes were ranked according to their level of resistance to P. infestans and discriminant analysis of gene expression profiles separated the most resistant genotype from the three others, particularly because of a strong induction of the salicylic acid (SA) pathway. In this genotype, transcripts involved in the SA pathway, EDS1, WRKY1, PR‐1 and PR‐2, were induced by CCF. SA pathway involvement was confirmed by a peak of SA accumulation 12 h after elicitation and by the induction of jaz1 (jasmonate Zim domain protein 1) transcripts, which inhibit defence responses mediated by jasmonic acid (JA). By contrast, neither a significant induction of SA‐mediated responses nor an accumulation of free SA and PR‐2 were observed in the other resistant or two susceptible cultivars. Expression of genes in the ET and JA pathways was either not, or weakly, induced by CCF in potato. Finally, the involvement of signalling pathways was genotype dependent rather than correlating with resistance level.
Reflections on Leadership: An Interview with Sean O'Keefe
Authors: Lambright W. Henry 
Published: June 2015

AbstractThis interview with Sean O'Keefe by PAR Associate Editor W. Henry Lambright is a departure from traditional Administrative Profiles. It represents an opportunity to elicit from a man who has held executive positions in government, industry, and the university lessons he has learned about leadership from those experiences. It is his perspective, in his own words, about a host of questions of interest to scholars and practitioners of public administration. These include commonalities and differences in leading organizations in various sectors. O'Keefe discusses how executives can deal with people and get the most from them, how executives use administrative power in achieving organizational goals, and why executives sometimes make the wrong calls in key decisions. He comments on what he learned about leadership from mentors during his formative years. He explains the limits he faced in making controversial decisions, such as his termination of a Hubble Space Telescope servicing mission.
Adult patients with respiratory syncytial virus infection: impact of solid organ and hematopoietic stem cell transplantation on outcomes
Authors: Pilie P. , Werbel W.A. , Riddell J. , Shu X. , Schaubel D. , Gregg K.S. 
Published: June 2015

AbstractBackgroundRespiratory syncytial virus (RSV) is a common community‐acquired pathogen responsible for a substantial disease burden in adults. We investigated the outcomes after RSV infection in hospitalized adults over a 3‐year period.MethodsThis single‐center, retrospective study identified 174 patients hospitalized with RSV upper or lower respiratory tract infection (LRTI) between January 1, 2009 and June 30, 2012. Clinical data were extracted from medical records. The primary outcome analyzed was all‐cause mortality, defined as death during the index hospital admission. Subjects were divided into 3 groups for comparison: hematopoietic stem cell transplant (HSCT) patients, solid organ transplant (SOT) patients, and non‐transplant patients.ResultsIn our study, 41/174 (23.6%) were HSCT recipients and 28/174 (16.1%) were SOT recipients. Twelve of 174 (6.9%) died. Death occurred in 2/41 (4.9%) HSCT and 3/28 (10.7%) SOT recipients, compared to 7/106 (6.6%) non‐transplant patients. When compared to the non‐transplant cohort, HSCT and SOT were not found to be significant risk factors for mortality (P = 0.685 and 0.645, respectively). In multivariate logistic regression, age >60 was associated with mortality (P = 0.019), while lymphopenia on admission trended toward an association with death (P = 0.054). HSCT patients were less likely to be admitted to an intensive care unit (odds ratio [OR] 0.26, P = 0.04), but were significantly more likely to receive ribavirin therapy (OR 11.62, P < 0.0001).ConclusionAdults hospitalized with RSV LRTI are at significant risk of mortality, and this risk may be increased in patients age >60 or with lymphopenia on admission. This study did not identify any significant increased mortality or morbidity associated with RSV infection in immune suppressed transplant recipients vs. patients who had not received a transplant.
Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFβ Signaling Pathway
Authors: Desnoyers Guillaume , Frost Laura D. , Courteau Lynn , Wall Michael L. , Lewis Stephen M. 
Published: June 2015

Abstract
The eIF3e protein is a component of the multisubunit eIF3 complex, which is essential for cap-dependent translation initiation. Decreased eIF3e expression is often observed in breast and lung cancer and has been shown to induce epithelial-to-mesenchymal transition (EMT) in breast epithelial cells by an unknown mechanism. Here, we study the effect of decreased eIF3e expression in lung epithelial cells by creating stable clones of lung epithelial cells (A549) that express an eIF3e-targeting shRNA. Our data indicate that decreased eIF3e expression in lung epithelial cells leads to EMT, as it does in breast epithelial cells. Importantly, we show that decreased eIF3e expression in both lung and breast epithelial cells leads to the overproduction of the TGFβ cytokine and that inhibition of TGFβ signaling can reverse eIF3e-regulated EMT in lung epithelial cells. In addition, we discovered that several mRNAs that encode important EMT regulators are translated by a cap-independent mechanism when eIF3e levels are reduced. These findings indicate that EMT mediated by a decrease in eIF3e expression may be a general phenomenon in epithelial cells and that it requires activation and maintenance of the TGFβ signaling pathway.
Implications: These results indicate that inhibition of TGFβ signaling could be an efficient way to prevent metastasis in patients with NSCLC that display reduced eIF3e expression. Mol Cancer Res; 13(10); 1421–30. ©2015 AACR.
Beneficial Regulation of Metabolic Profiles by Black Raspberries in Human Colorectal Cancer Patients
Authors: Pan Pan , Skaer Chad W. , Stirdivant Steven M. , Young Matthew R. , Stoner Gary D. , Lechner John F. , Huang Yi-Wen , Wang Li-Shu 
Published: June 2015

AbstractDietary intervention of freeze-dried black raspberries (BRBs) in a group of human colorectal cancer patients has demonstrated beneficial effects, including proapoptosis, antiproliferation, and antiangiogenesis. The aim of this study was to investigate BRB-mediated metabolite changes from this same cohort of patients. Twenty-eight colorectal cancer patients were given 60 g BRB powder daily for 1 to 9 weeks. Urine and plasma specimens were collected before and after BRB intervention. A mass spectrometry–based nontargeted metabolomic analysis was conducted on each specimen. A total of more than 400 metabolites were annotated in each specimen. Of these 34 and 6 metabolites were significantly changed by BRBs in urine and plasma, respectively. Increased levels of 4-methylcatechol sulfate in both post-BRB urine and post-BRB plasma were significantly correlated with a higher level of apoptotic marker (TUNEL) in post-BRB tumors. One tricarboxylic acid (TCA) cycle metabolites, cis-aconitate, was increased in post-BRB urine. Furthermore, BRB-derived polyphenols were absorbed and metabolized to various benzoate species, which were significantly increased in post-BRB specimens. Increased benzoate levels were positively correlated with enhanced levels of amino acid metabolite. These results suggest that BRBs induce significant metabolic changes and affect energy generating pathways.This study supports the hypothesis that BRBs might be beneficial to colorectal cancer patients through the regulation of multiple metabolites. Cancer Prev Res; 8(8); 743–50. ©2015 AACR.
ІНФОРМАЦІЙНО-ОБЛІКОВА СИСТЕМА СПОСТЕРЕЖЕННЯ ЗА ХВОРИМИ НА МУКОВІСЦИДОЗ
Authors: Zhurovsky M. Z. , Horovenko N. H. , Stetsyuk V. Z. , Savytskyi A. I. , Hladush Yu. I. , Ivanova T. P. , Luhovskyi Yu. O. 
Published: June 2015

<p>To assist in controlling the process of treat ment and monitoring of patients was developed a software application that captures all the work with the patient. For developing this application were used medical records, statistical reporting forms, other medical documentation and doctor experience.<br />This software saves doctor’s time, or ganizes their work, improves perfor mance and allows focusing on the patient.</p>
СПОСІБ РОЗРАХУНКУ ЛОКАЛІЗАЦІЇ ДЖЕРЕЛА ШУМІВ У ТРИВИМІРНОМУ ПРОСТОРІ ДЛЯ ДІАГНОСТИКИ ПНЕВМОНІЇ У ДІТЕЙ МОЛОДШОГО ВІКУ
Authors: Apikova A. E. , Fedotov D. A. , Klymenko V. A. 
Published: June 2015

<p>The theoretical justification for using of the GPS-technology principle for the pneumonia diagnosis was made in the article. The sensor's matrix is located on a patient's chest and it's an inactive system's component unlike satellites used in GPS. The method is i mplemented using t he GPS-navigation formula with some variables replacements. For determining of the coordinates of the sounds source in the three-dimensional space it's necessary to calculate time from sound's source to each sensor of matrix. According to the obtained coordinates the conclusion about the depth and location of the inflammation process (pneumonia) in the patient lungs can be made.</p>
МОЖЛИВОСТІ ЗАСТОСУВАННЯ ТЕХНОЛОГІЙ ДИСТАНЦІЙНОГО НАВЧАННЯ В БЕЗПЕРЕРВНОМУ ПРОФЕСІЙНОМУ РОЗВИТКУ ПРОВІЗОРІВ
Authors: Babintseva L. Yu. 
Published: June 2015

<p>The possibilities of distance learning technologies to provide effective continuing professional development of ph ar macists<br />was discussed. Improving the quality of this study is to provide adaptability and confor mity knowledge transfer. Applying the principles of individualized learning was improved quality of learning more. Individualization of training can reduce the amount of errors in decision-making (analysis of situational tasks) more than twice was proved.</p>
АВТОМАТИЗАЦІЯ СИСТЕМИ ВНУТРІШНЬОЛАБОРАТОРНОГО КОНТРОЛЮ ЯКОСТІ
Authors: Stetsyuk V. Z. , Savickiy A. I. , Ivanova T. P. , Olhovich N. V. , Horbenko A. O. 
Published: June 2015

<p>Quality control system base d on the principles of standardi zation of all phases of laboratory testing and analysis of internal laboratory quality control and external quality assessment. For the detection accuracy of the results of laboratory tests, carried out internally between the laboratory and laboratory quality control. Under internal laboratory quality control we understand measurement results of each analysis in each anal ytical series rendered directly in the lab every day. The purpose of internal laboratory control - identifying and eliminating unacceptable deviations from standard perfor mance test in the laboratory, i.e. identifying and eliminating harmful analytical errors. The solutions to these problems by implementing automated systems - software that allows you to optimize analytical laboratory research stage of the procedure by automatically creating process control charts was shown.</p>
СТАТИСТИЧНЕ ОБГРУНТУВАННЯ КОМПЕНСАТОРНИХ МЕХАНІЗМІВ ЕПІТЕЛІЮ ЯСЕН В УМОВАХ НІКОТИНОВОЇ ІНТОКСИКАЦІЇ
Authors: Gasyuk N. V. 
Published: June 2015

<p>In the article the results of a comprehensive statistical study of compensatory mechanisms of restructuring epithelium nicotine gum under conditions of intoxication. The results make it possible to characterize changes сytospecific described as a tendency to develop incomplete keratinization, as evidenced virohidnene increase in the number of surface cells on the background of reduction of horny scales. The appearance in cytohrams parabasal epithelial cells ch aracterizes activation<br />of compensatory mechanisms in epithelial conditions nicotine intoxication.</p>
An Automated Mobile Phone Photo Relay and Display Concept Applicable to Operational Severe Weather Monitoring
Authors: Longmore Scott , Miller Steven , Bikos Dan , Lindsey Daniel , Szoke Edward , Molenar Debra , Hillger Donald , Brummer Renate , Knaff John 
Published: June 2015

AbstractThe increasing use of mobile phones (MPs) equipped with digital cameras and the ability to post images and information to the Internet in real time has significantly improved the ability to report events almost instantaneously. From the perspective of weather forecasters responsible for issuing severe weather warnings, the old adage holds that a picture is indeed worth a thousand words; a single digital image conveys significantly more information than a simple web-submitted text or phone-relayed report. Timely, quality-controlled, and value-added photography allows the forecaster to ascertain the validity and quality of storm reports. The posting of geolocated, time-stamped storm report photographs utilizing an MP application to U.S. National Weather Service (NWS) Weather Forecast Office (WFO) social media pages has generated recent positive feedback from forecasters. This study establishes the conceptual framework, architectural design, and pathway toward implementation of a formalized photo report (PR) system composed of 1) an MP application, 2) a processing and distribution system, and 3) the Advanced Weather Interactive Processing System II (AWIPS II) data plug-in software. The requirements and anticipated appearance of such a PR system are presented, along with considerations for possible additional features and applications that extend the utility of the system beyond the realm of severe weather applications.