bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of kinesio taping as a complementary therapy to conventional techniques in the rehabilitation of patients with rheumatoid arthritis following total knee arthroplasty
Authors: Prusinowska Agnieszka , Turski Piotr , Cichocki Tomasz , Kowalik Katarzyna , Woszuk Katarzyna , Małdyk Paweł , Księżopolska-Orłowska Krystyna 
Published: September 2014

Oczekiwania dotyczące wczesnej rehabilitacji – aby w jak najkrótszym czasie osiągnąć dobre wyniki usprawniania – powodują, że program terapii po leczeniu operacyjnym musi zawierać wiele metod wspomagających samodzielne funkcjonowanie pacjenta. Kinesiotaping jako metoda usprawniania pacjenta po zabiegu <br />
chirurgicznym jest coraz częściej stosowana, wykazuje zróżnicowane działanie terapeutyczne i jednocześnie jest dobrze tolerowana przez chorych.<br />
W artykule zamieszczono szczegółowe opisy aplikacji plastrów do kinesiotapingu, jakie są stosowane w reumoortopedii po endoprotezoplastyce stawu kolanowego. Mają one istotny wpływ na poprawę samodzielności osób z zaawansowanymi zmianami destrukcyjnymi w obrębie pozostałych stawów. Opisy aplikacji zostały podzielone pod względem ich działania i czasu stosowania po operacji. W tekście wyróżniono aplikacje przeciwobrzękowe, korekcyjne i na bliznę pooperacyjną, których celem jest wspomaganie procesu usprawniania od pierwszej doby po zabiegu chirurgicznym.
Embedded resource accounting for coupled natural‐human systems: An application to water resource impacts of the western U.S. electrical energy trade
Authors: Ruddell Benjamin L. , Adams Elizabeth A. , Rushforth Richard , Tidwell Vincent C. 
Published: September 2014

AbstractIn complex coupled natural‐human systems (CNH), multitype networks link social, environmental, and economic systems with flows of matter, energy, information, and value. Embedded Resource Accounting (ERA) is a systems analysis framework that includes the indirect connections of a multitype CNH network. ERA is conditioned on perceived system boundaries, which may vary according to the accountant's point of view. Both direct and indirect impacts are implicit whenever two subnetworks interact in such a system; the ratio of two subnetworks' impacts is the embedded intensity. For trade in the services of water, this is understood as the indirect component of a water footprint, and as “virtual water” trade. ERA is a generalization of input‐output, footprint, and substance flow methods, and is a type of life cycle analysis. This paper presents results for the water and electrical energy system in the western U.S. This system is dominated by California, which outsources the majority of its water footprint of electrical energy. Electricity trade increases total water consumption for electricity production in the western U.S. by 15% and shifts water use to water‐stressed Colorado River Basin States. A systemic underaccounting for water footprints occurs because state‐level processes discount a portion of the water footprint occurring outside of the state boundary.
An altitude and distance correction to the source fluence distribution of TGFs
Authors: Nisi R. S. , Østgaard N. , Gjesteland T. , Collier A. B. 
Published: September 2014

AbstractThe source fluence distribution of terrestrial gamma ray flashes (TGFs) has been extensively discussed in recent years, but few have considered how the TGF fluence distribution at the source, as estimated from satellite measurements, depends on the distance from satellite foot point and assumed production altitude. As the absorption of the TGF photons increases significantly with lower source altitude and larger distance between the source and the observing satellite, these might be important factors. We have addressed the issue by using the tropopause pressure distribution as an approximation of the TGF production altitude distribution and World Wide Lightning Location Network spheric measurements to determine the distance. The study is made possible by the increased number of Ramaty High Energy Solar Spectroscopic Imager (RHESSI) TGFs found in the second catalog of the RHESSI data. One find is that the TGF/lightning ratio for the tropics probably has an annual variability due to an annual variability in the Dobson‐Brewer circulation. The main result is an indication that the altitude distribution and distance should be considered when investigating the source fluence distribution of TGFs, as this leads to a softening of the inferred distribution of source brightness.
Asymmetric influence of boreal spring Arctic Oscillation on subsequent ENSO
Authors: Chen Shangfeng , Chen Wen , Yu Bin 
Published: September 2014

AbstractPrevious studies have suggested that the boreal spring Arctic Oscillation (AO) could exert a significant influence on the outbreak of El Niño–Southern Oscillation (ENSO) during the following winter. This study further reveals that the influence of the spring AO on the subsequent ENSO is asymmetric. When the spring AO is in its high phase, significant El Niño‐like sea surface temperature (SST) warming anomalies are observed over the tropical central eastern Pacific in the following winter. However, when the spring AO is in its low phase, negative SST anomalies over the tropical central eastern Pacific are weak and statistically insignificant. This asymmetric influence is attributed to the asymmetric features of both the atmospheric circulation anomalies in spring and atmospheric heating anomalies over the subtropical North Pacific from spring to summer. For the high AO phase composite, the anomalous cyclonic circulation over the subtropical western North Pacific and the related westerly wind anomalies to its south over the tropical western Pacific are strong and significant in spring. The tropical zonal wind anomalies would trigger ENSO events via the excitation of an eastward propagating Kelvin wave. Meanwhile, the atmospheric heating anomalies over the subtropical North Pacific play an important role in sustaining the westerly wind over the tropical western Pacific from spring to summer. In contrast, the counterparts in the low AO phase composite are weak and statistically insignificant. Our results indicate that the phase of spring AO should be taken into account when using spring AO as a predictor for ENSO.
Future climate projection under IPCC A1B scenario in the source region of Yellow River with complex topography using RegCM3
Authors: Hui Pinhong , Tang Jianping , Wang Shuyu , Wu Jian , Kang Yue 
Published: September 2014

AbstractLocated on the Tibetan Plateau, the source region of Yellow River has experienced remarkable climate change over past a few decades, which affects the regional ecosystem, agricultural development, and water availability. In this paper, high‐resolution RegCM3 driven by ECHAM5 is applied to generate both control climate for 1980–2000 and regional climate projections for the 21st century (2010–2098) under the Intergovernmental Panel on Climate Change (IPCC) A1B emission scenario. For control climate, RegCM3 can well reproduce the spatial patterns of precipitation and surface air temperature with more detailed representation of fine scale topography. Wet and cold biases are produced in the simulation, but overall improvement by RegCM3 is evident compared to the driving global climate model (GCM) of ECHAM5. In the future projection, the model demonstrates significant warming over the whole analysis domain. Precipitation on the other hand shows mixed signals of reduction and increase over simulation domain, while the areas of precipitation reduction extend with increasing integration time and finally cover most parts of the domain at the end of 21st century. As projection time increases, high altitude region will experience more precipitation reduction in summer and less reduction or even increase in winter. The winter warming at the high elevation area gets more evident than that at the low elevation area, which may be due to the snow feedback. Analyzing the change of probability distributions of surface climate, it can be concluded that the frequency of heavy precipitation in winter tends to increase with time indicating more extreme precipitation events in the future. The spectrum of temperature probability density functions (PDFs) moves toward higher end.
Phosphotungstic Acid as an Efficient Catalyst for Allylation of Isatins and N‐tert‐Butyloxycarbonylamido Sulfones Under Solvent‐Free Conditions
Authors: Ghosh Debashis , Saravanan S. , Gupta Naveen , Abdi Sayed H. R. , Khan Noor‐ul H. , Kureshy Rukhsana I. , Bajaj Hari C. 
Published: September 2014

AbstractThe present work demonstrates the use of phosphotungstic acid (H3PW12O40⋅H2O) as an efficient catalyst for the allylation of isatin derivatives as well as N‐tert‐butyloxycarbonyl (Boc)‐α‐amido sulfones with allyltributyltin as an allylating agent under solvent‐free conditions at room temperature. Excellent allylation product yields of up to 99 % for the isatins substrates and good to excellent yields of up to 98 % for the N‐Boc α‐amido sulfones were obtained. The present allylation protocol is scalable as demonstrated by allylation of N‐methylisatin at 1 g scale. Based on 1H, 13C, and 31P NMR studies a catalytic cycle was proposed for allylation of isatins as well as N‐Boc amido sulfones. The allylation products N‐Boc homoallyl amines were successfully epoxidized to get multifunctional compounds, which are valuable intermediates for natural products and bioactive compounds.
Die asymmetrische Hetero‐Diels‐Alder‐Reaktion in Synthesen biologisch relevanter Verbindungen
Authors: Eschenbrenner‐Lux Vincent , Kumar Kamal , Waldmann Herbert 
Published: September 2014

AbstractDie Hetero‐Diels‐Alder‐Reaktion gehört zu den effizientesten Umwandlungen im chemischen Repertoire für die Synthese von Aza‐ und Oxaheterocyclen mit mehreren Stereozentren. Allerdings wurde die Hetero‐Diels‐Alder‐Reaktion sehr viel weniger untersucht und in der organischen Synthese angewendet als andere Cycloadditionen, besonders dipolare Cycloadditionen und Diels‐Alder‐Reaktionen. Dennoch ermöglichte diese leistungsfähige Umwandlung effiziente und kreative Synthesewege zu biologisch wichtigen niedermolekularen Verbindungen und verschiedenen Naturstoffen mit sechsgliedrigen Sauerstoff‐ und Stickstoffringsystemen. Der Aufsatz beleuchtet die jüngsten Entwicklungen auf diesem Gebiet, insbesondere im Hinblick auf die Einführung enantioselektiv katalysierter Hetero‐Diels‐Alder‐Cycloadditionen, die durch eine Fülle verschiedener Katalysatoren gesteuert werden, und die Anwendung der so erhaltenen niedermolekularen Verbindungen für die Forschung in der chemischen Biologie und der medizinischen Chemie.
Ground‐penetrating radar and burial practices in western Arnhem Land, Australia
Authors: Lowe Kelsey M. , Wallis Lynley A. , Pardoe Colin , Marwick Ben , Clarkson Chris , Manne Tiina , Smith Mike A. , Fullagar Richard 
Published: September 2014

AbstractA GPR survey was carried out in advance of archaeological excavations at Madjedbebe (formerly known as Malakunanja II), a sandstone rock shelter in western Arnhem Land (Australia) containing numerous Aboriginal burials. GPR revealed subsurface patterning of rocks in the shelter deposits and archaeological excavation demonstrated that these were related to burials. Post‐excavation, GIS and statistical analysis further elucidated the relationship between the rocks and human burials. This integration of detailed mapping, GPR and excavation afforded the opportunity to test a way to identify unmarked burials using GPR in sandstone rock shelters and to document a marker for burial identification in this region. Application of the methodology developed through this case study provides a useful management tool for Indigenous communities and other heritage practitioners.
Expression and Function of Aminopeptidase N/CD13 Produced by Fibroblast‐like Synoviocytes in Rheumatoid Arthritis: Role of CD13 in Chemotaxis of Cytokine‐Activated T Cells Independent of Enzymatic Activity
Authors: Morgan Rachel , Endres Judith , Behbahani‐Nejad Nilofar , Phillips Kristine , Ruth Jeffrey H. , Friday Sean C. , Edhayan Gautam , Lanigan Thomas , Urquhart Andrew , Chung Kevin C. , Fox David A. 
Published: September 2014

ObjectiveAminopeptidase N/CD13 (EC 3.4.11.2) is a metalloproteinase expressed by fibroblast‐like synoviocytes (FLS). It has been suggested that CD13 can act chemotactically for T cells in rheumatoid arthritis (RA). We undertook this study to measure CD13 in vivo and in vitro in RA samples and to determine whether CD13 could play a role in the homing of T cells to the RA joint.MethodsInterleukin‐17–treated FLS were used to immunize mice, from which a novel anti‐human CD13 monoclonal antibody (mAb), 591.1D7.34, was developed. The mAb 591.1D7.34 and a second anti‐CD13 mAb, WM15, were used to develop a novel enzyme‐linked immunosorbent assay (ELISA) for CD13, and CD13 enzymatic activity was measured in parallel. Chemotaxis of cytokine‐activated T cells was measured by a chemotaxis‐under‐agarose assay.ResultsWe detected substantial amounts of CD13 in synovial fluid (SF), sera, FLS lysates, and culture supernatants by ELISA, with a significant increase in CD13 in RA SF when compared to osteoarthritis SF. CD13 accounted for most but not all of the CD13‐like enzymatic activity in SF. Recombinant human CD13 was chemotactic for cytokine‐activated T cells through a G protein–coupled receptor and contributed to the chemotactic properties of SF independently of enzymatic activity.ConclusionCD13 is released from FLS into culture supernatants and is found in SF. CD13 induces chemotaxis of cytokine‐activated T cells, a T cell population similar to that found in RA synovium. These data suggest that CD13 could play an important role as a T cell chemoattractant, in a positive feedback loop that contributes to RA synovitis.
Control of 3d Tower Crane Based on Tensor Product Model Transformation With Neural Friction Compensation
Authors: Matuško Jadranko , Ileš Šandor , Kolonić Fetah , Lešić Vinko 
Published: September 2014

AbstractFast and accurate positioning and swing minimization of heavy loads in crane manipulation are demanding and, at the same time, conflicting tasks. Accurate load positioning is primarily limited by the existence of a nonlinear friction effect, especially in the low speed region. In this paper the authors propose a new control scheme for 3D tower crane, that consists of a tensor product model transformation based nonlinear feedback controller, with an additional neural network based friction compensator. Tensor product based controller is designed using linear matrix inequalities utilizing a parameter varying Lyapunov function. Neural network parameters adaptation law is derived using Lyapunov stability analysis. The simulation and experimental results on a 3D laboratory crane model are presented.
Cycle‐by‐Cycle Adaptive Force Compensation for the Soft‐Landing Control of an Electro‐Mechanical Engine Valve Actuator
Authors: di Gaeta Alessandro , Hoyos Velasco Carlos I. , Montanaro Umberto 
Published: September 2014

AbstractElectro‐mechanical valve actuators (EMVA) are a solution for implementing variable valve actuation in internal combustion engines. Their use can increase engine power, reduce fuel consumption and pollutant emissions, while significantly improving engine efficiency. The control of this actuator is a complex task since non‐smooth nonlinearities, parameter variations and external forces strongly affect plant dynamics. In addition, the impact of the valve at its end‐strokes translates into mechanical wear and unacceptable noise, and in the worst case the electromagnet may also fail to catch the valve, causing system failure. The design of effective control strategies to ensure valve capture with low impact velocities is therefore essential for the correct functioning of such a mechatronic device. In this paper, the control problem of reducing the impact velocity at “landing” known in the literature as soft landing control, is tackled via novel cycle‐by‐cycle adaptive force compensation control algorithms. Two schemes are presented: a discrete adaptive proportional integral controller to regulate landing velocity to a preassigned set‐point, and a gradient descent method based controller to automatically achieve the minimum admissible impact velocity. The effectiveness of both methods in limiting landing velocities is shown numerically using a high predictive simulator of the EMVA system, when considering unknown varying environmental conditions, such as internal friction and external gas pressure forces.
Sensitive and selective determination of fluvoxamine maleate using a sensitive chemiluminescence system based on the alkaline permanganate–Rhodamine B–gold nanoparticles reaction
Authors: Hassanzadeh Javad , Amjadi Mohammad 
Published: September 2014

AbstractA high‐yield chemiluminescence (CL) system based on the alkaline permanganate–Rhodamine B reaction was developed for the sensitive determination of fluvoxamine maleate (Flu). Rhodamine B is oxidized by alkaline KMnO4 and a weak CL emission is produced. It was demonstrated that gold nanoparticles greatly enhance this CL emission due to their interaction with Rhodamine B molecules. It is also observed that sodium dodecyl sulfate, an anionic surfactant, can strongly increase this enhancement. In addition, it was demonstrated that a notable decrease in the CL intensity is observed in the presence of Flu. This may be related to Flu oxidation with KMnO4. There is a linear relationship between the decrease in CL intensity and the Flu concentration over a range of 2–300 µg/L. A new simple, rapid and sensitive CL method was developed for the determination of Flu with a detection limit (3s) of 1.35 µg/L. The proposed method was used for the determination of Flu in pharmaceutical and urine samples. Copyright © 2014 John Wiley & Sons, Ltd.
A robust transfection reagent for the transfection of CHO and HEK293 cells and production of recombinant proteins and lentiviral particles – PTG1
Authors: Gonçalves Cristine , Gross Fabian , Guégan Philippe , Cheradame Hervé , Midou Patrick 
Published: September 2014

AbstractBioproduction of recombinant proteins (r‐proteins) and recombinant lentiviral particles (r‐lentiviral particles) requires robust transfections consisting of efficient protocols that are easy to implement, with good reproducibility for a maximum production of proteins and lentiviral particles in a short time with low cytotoxicity. This study evaluates the capacity of histidinylated polyethyleneimine I (PTG1) to facilitate robust DNA transfection, with low cytotoxicity, of Chinese hamster ovary (CHO) and human embryonic kidney (HEK293T) cells for the production of r‐proteins and r‐lentiviral particles. We report that PTG1 transfection of cells in suspension with a plasmid DNA encoding enhanced green fluorescent protein leads to 72 and 97% of transfected CHO and HEK293T cells respectively, and does not significantly affect cell viability. PTG1 transfection of 100 mL of CHO‐S cell culture in suspension at a cell density of 2 × 106 cells /mL resulted in a high level of transfected cells and protein expression after transfection with 0.75 μg/mL plasmid DNA. Transfection with PTG1 is more efficient than LipofectAmine2000™, and gene expression is higher than observed with FreeStyle™ and JetPEI®. Tri‐transfection of HEK293T packaging cells leads to the production of a higher level of r‐lentiviral particles compared to the calcium phosphate method, and permits two harvests of viral particles within three days. These results show that PTG1 is a powerful new transfection reagent for cell lines frequently used for recombinant protein and lentiviral particle production. PTG1 could be used in protocols for bioproduction of therapeutic proteins such as antibodies for cancer treatments and viral vectors for gene therapy applications.
Tumor‐activated prodrug (TAP)‐conjugated nanoparticles with cleavable domains for safe doxorubicin delivery
Authors: Guarnieri Daniela , Biondi Marco , Yu Hui , Belli Valentina , Falanga Andrea P. , Cantisani Marco , Galdiero Stefania , Netti Paolo A. 
Published: September 2014

ABSTRACTA major issue in chemotherapy is the lack of specificity of many antitumor drugs, which cause severe side effects and an impaired therapeutic response. Here we report on the design and characterization of model tumor activated prodrug‐conjugated polystyrene (PS) nanoparticles (TAP‐NPs) for the release of doxorubicin (Dox) triggered by matrix metalloprotease‐2 (MMP2) enzyme, which is overexpressed in the extracellular matrix of tumors. In particular, TAP‐NPs were produced by attaching Dox to poly(ethylene glycol) (PEG) through two MMP2—cleavable enzymes. The resulting adduct was then tethered to PS NPs. Results showed that Dox release was actually triggered by MMP2 cleavage and was dependent on enzyme concentration, with a plateau around 20 nM. Furthermore, significant cell cytotoxicity was observed towards three cell lines only in the presence of MMP2, but not in cells without enzyme pre‐treatment, even after NP internalization by cells. These findings indicate the potential of TAP‐NPs as suitable nanocarriers for an on demand, tumor—specific delivery of antitumor drugs after the response to an endogenous stimulus. Further advancements will focus on the translation of this production technology to biodegradable systems for the safe transport of cytotoxic drug to tumor tissues. Biotechnol. Bioeng. 2015;112: 601–611. © 2014 Wiley Periodicals, Inc.
Cathodic Corrosion of Cu Substrates as a Route to Nanostructured Cu/M (M=Ag, Au, Pd) Surfaces
Authors: Najdovski Ilija , Selvakannan PR , O'Mullane Anthony P. 
Published: September 2014

AbstractThe electrochemical formation of nanostructured materials is generally achieved by reduction of a metal salt onto a substrate that does not influence the composition of the deposit. In this work, we report that Ag, Au and Pd electrodeposited onto Cu under conditions where galvanic replacement is not viable and hydrogen gas is evolved results in the formation of nanostructured surfaces that unexpectedly incorporate a high concentration of Cu in the final material. Under cathodic polarisation conditions, the electrodissolution/corrosion of Cu occurs, which provides a source of ionic copper that is reduced at the surface–electrolyte interface. The nanostructured Cu/M (M=Ag, Au and Pd) surfaces are investigated for their catalytic activity for the reduction of 4‐nitrophenol by NaBH4, where Cu/Ag was found to be extremely active. This work indicates that a substrate electrode can be utilised in an interesting manner to make bimetallic nanostructures with enhanced catalytic activity.
Nonsymmetrical 3,4‐Dithienylmaleimides by Cross‐Coupling Reactions with Indium Organometallics: Synthesis and Photochemical Studies
Authors: Mosquera Ángeles , Férnandez M. Isabel , Canle Lopez Moisés , Pérez Sestelo José , Sarandeses Luis A. 
Published: September 2014

AbstractThe synthesis and photochemical study of novel nonsymmetrical 1,2‐dithienylethenes (DTEs) with a maleimide bridge have been carried out. The synthetic approach to the DTEs was based on successive selective palladium‐catalyzed cross‐coupling reactions of 5‐susbtituted‐2‐methyl‐3‐thiophenyl indium reagents with 3,4‐dichloromaleimides. The required organoindium reagents were prepared from 2‐methyl‐3,5‐dibromothiophene by a selective (C‐5) coupling reaction with triorganoindium compounds (R3In) and subsequent metal–halogen exchange. The coupling reactions usually gave good yields and have a high atom economy with substoichiometric amounts of R3In. The results of photochemical studies show that these novel dithienylmaleimides undergo a photocyclization reaction upon irradiation in the UV region and a photocycloreversion after excitation in the visible region, thus they can be used as photochemical switches. ON–OFF operations can be repeated in successive cycles without appreciable loss of effectiveness in the process.