bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preload reduction with right ventricular pacing: Effects on left ventricular hemodynamics and contractile pattern
Authors: Hamby R. I. , Aintablian A. 
Published: October 2013

AbstractStudies were performed in 32 patients to evaluate left ventricular pressure‐volume changes and contractile pattern during right ventricular pacing as compared to normal sinus rhythm. Coronary artery disease was present in 27 patients, while 5 patients (control group) had no evidence of coronary artery or left ventricular disease. Studies were performed during both normal sinus rhythm and right ventricular pacing at comparable heart rates, utilizing angiographic methods to determine heart volumes. Right ventricular pacing in all patients resulted in decreased left ventricular systolic (p< 0.01) and diastolic (p< 0.01) pressures and decreased stroke work (p< 0.001). In the control group, right ventricular pacing caused a decrease in left ventricular end‐diastolic volume (p< 0.01) and stroke volume (p< 0.01), with no change in ejection fraction. The patients with coronary artery disease were divided into four groups, dependent on the left ventricular contractile pattern during normal sinus rhythm and the percentage of change in hemiaxis shortening during right ventricular pacing. In group A (six patients with asynergy) and group B (seven patients with asynergy), there was no significant change in the percentage of hemiaxis shortening during right ventricular pacing when compared to normal sinus rhythm. Ventricular volume studies in these patients (groups A and B) were similar to the control groups and no change in contractile pattern was observed during pacing. In group C, twelve patients had asynergy and a 10% increase in percentage of hemiaxis shortening during right ventricular pacing when compared to normal sinus rhythm. Right ventricular pacing resulted in decreased end‐diastolic pressure (p< 0.01) and end‐diastolic volume (p< 0.001), no change in stroke volume, and an increased ejection fraction (p< 0.01). Contractile patterns improved in all patients in group C during pacing. Group D consisted of two patients with asynergy and a 10% decrease in percentage of hemiaxis shortening during pacing, associated with a decrease in end‐diastolic volume and ejection fraction with deterioration of left ventricular contractile pattern.These results indicate that right ventricular pacing in patients with coronary artery disease decreases preload, which may be accompanied by improved left ventricular contractile pattern (11/27) and in some patients (2/27) deterioration of left ventricular function.
Relationship of circulating thyroid antibodies to coronary artery disease
Authors: Piziak V. K. , Litman G. I. , Bratcher T. 
Published: October 2013

AbstractA study of the relationship between circulating thyroid antibodies and coronary artery disease was performed. In 180 patients, the state of the coronary arteries was determined by cardiac catheterization and antithyroglobulin and antimicrosomal antibodies were measured using immunoprecipitation. The prevalence of risk factors for coronary artery disease and the mean age of the groups with and without coronary artery disease were similar. There was no significant difference in the prevalence of thyroid antibodies in patients with or without coronary artery disease.
Two‐channel ECG monitoring in the coronary care unit
Authors: Hasin Y. , Freiman I. , Gotsman M. S. 
Published: October 2013

AbstractWe describe the installation and clinical application of a two‐channel monitoring system in the intensive coronary care unit using a single patient cable and two exchangeable ECG modules. Routine use of this system during a period of three years has shown that it has many advantages in the precise documentation and diagnosis of transient cardiac arrhythmias and for the recognition and localization of ischemic episodes.
Massive prostatic infarction following aortocoronary bypass surgery: A report of two cases
Authors: Taussig A. S. , Hurst J. W. , Ambrose S. S. , Sewell C. W. 
Published: October 2013

AbstractWe present two patients who had massive prostatic infarctions following coronary bypass surgery. Whereas small areas of prostatic infarction are commonly seen in urologic practice, massive infarction is rarely seen. Massive prostatic infarction has been observed under conditions similar to those occurring with bypass surgery, so no claim is made that the condition occurs uniquely in patients who have recently undergone bypass surgery. Since coronary bypass surgery is commonly performed and since the procedure is often done on men with prostatic hyperplasia, we can reasonably expect to see this condition more commonly that we have in the past. It is our hope that others will be alerted to this condition and look for it in patients with prostatism who undergo coronary bypass surgery, other types of cardiac surgery, and any condition where prostatism and hypotension are present and pressor agents are used in treatment.
The effect of photoreceptor degeneration on ganglion cell morphology
Authors: O'Brien E.E. , Greferath U. , Fletcher E.L. 
Published: October 2013

ABSTRACTRetinitis pigmentosa refers to a family of inherited photoreceptor degenerations resulting in blindness. During and after photoreceptor loss, neurons of the inner retina are known to undergo plastic changes. Here, we have investigated in detail whether ganglion cells are altered at late stages of degeneration, well after the total loss of photoreceptors. We used mice, rd1‐Thy1, that carry a mutation in the β‐subunit of phosphodiesterase 6 and a fluorescent protein that labels a subset of ganglion cells and B6‐Thy1 control mice. Retinal wholemounts from mice aged 3–11 months were processed for immunohistochemistry and analyzed. Ganglion cells were classified based on soma area, dendritic field size, and branching of dendrites. The dendritic fields of some ganglion cells were further analyzed for their length, area and quantity of branching points. There was a decrease in size and level of branching of A2, B1, and D type ganglion cells in the degenerated retina at 11 months of age. In contrast, C1 ganglion cells remained unchanged. In addition, there was a shift in the proportion of ganglion cells ramifying in the different layers of the inner plexiform layer. Careful analysis of the dendrites of ganglion cells revealed some projecting to new, more distal regions of the inner plexiform layer. We propose that these changes in ganglion cell morphology could impact the function of individual cells as well as the retinal circuitry in the degenerated retina. J. Comp. Neurol. 522:1155–1170, 2014. © 2013 Wiley Periodicals, Inc.
Comparative phylogeographic study of Hosta sieboldiana and Hosta albomarginata (Asparagaceae) in Japan
Authors: Lee Sangryong , Maki Masayuki 
Published: October 2013

AbstractWe analyzed variations in chloroplast DNA (cpDNA) in the widespread herbaceous species Hosta sieboldiana and Hosta albomarginata across large portions of their geographic ranges in the Japanese archipelago. Our objective was to compare the phylogeographic histories and phylogeographic structures of the two congeneric species in the Japanese archipelago. The location of the study is Japanese archipelago. We sequenced 1380 bp of noncoding cpDNA from 45 populations of H. sieboldiana (n = 362) and 55 populations of H. albomarginata (n = 436) to assess genetic variations within and among populations across almost the entire distributions of the species in Japan. Extant patterns of geographic structure were analyzed using statistical parsimony networks and spatial analysis of molecular variance (SAMOVA). We also used Monmonier's algorithm to detect genetic barriers between regions. Relationships between the populations were examined using a neighbor‐joining (NJ) method. Four haplotypes were found for H. sieboldiana, whereas eight haplotypes were identified for H. albomarginata. Total genetic haplotype diversity (hT) and within‐population haplotype diversity (hS) for H. sieboldiana were 0.352 and 0.040, respectively, while the values for H. albomarginata were 0.529 and 0.085, respectively. The population differentiations (GST) for H. sieboldiana and H. albomarginata were 0.839 and 0.886, respectively. The SAMOVA analysis revealed two clusters in H. sieboldiana and four clusters in H. albomarginata. Differentiations between and among the clusters were supported by the BARRIER analysis and the NJ tree. We detected differences in the population genetic structure between the two species. We found that H. sieboldiana had lower haplotype diversity than H. albomarginata. These results may be partially explained by the difference in ecological habitats and geographic distributions between the species. Hosta albomarginata is more widely distributed than H. sieboldiana in East Asia including Russia, and this large distribution range would enable more chances to intraspecific gene flow.
DoE (Design of Experiments) Assisted Allylic Hydroxylation of Enones Catalysed by a Copper–Aluminium Mixed Oxide
Authors: García‐Cabeza Ana Leticia , Marín‐Barrios Rubén , Azarken Redouan , Moreno‐Dorado F. Javier , Ortega María J. , Vidal Hilario , Gatica José M. , Massanet Guillermo M. , Guerra Francisco M. 
Published: October 2013

AbstractThe allylic hydroxylation of enones using dioxygen as the oxidant has been studied. The reaction was first examined in the absence of any catalyst, using β‐ionone as a model substrate. Then a new copper–aluminium mixed oxide, Cu–Al Ox, was prepared and characterized in order to be used as a catalyst. This oxide showed good activity, and provided the corresponding γ‐ or ϵ‐hydroxylated enones, starting from different α,β‐ or α,β,γ,δ‐unsaturated ketones. In all cases, the yields were significantly improved compared to experiments run in the absence of the catalyst. The reaction was selective, and the formation of epoxides or other overoxidation products was detected only to a minor extent. The described procedure is a technically straightforward synthetic alternative to those methods described to date involving many reaction steps or toxic reagents. The reactions were optimized using design of experiments techniques (DoE).
Platinum Ultramicroelectrodes Modified with Electrogenerated Surfactant‐Templated Mesoporous Organosilica Films: Effect of Film Formation Conditions on Its Performance in Preconcentration Electroanalysis
Authors: Herzog Grégoire , Vodolazkaya Natalya A. , Walcarius Alain 
Published: October 2013

AbstractPt µdisc electrodes have been modified by mesoporous organosilica thin films by electrochemically assisted self‐assembly (EASA) of mercaptopropyltrimethoxysilane (MPTMS), tetraethoxysilane (TEOS), and the surfactant cetyltrimethylammonium bromide (CTAB). The EASA process involves the generation of hydroxide ions at the electrode/solution interface, upon the application of a cathodic current density, leading to TEOS and MPTMS polycondensation around the CTAB template and concomitant growing of a thiol‐functionalized mesoporous film onto the electrode surface. The experimental conditions (current density, deposition time, silane concentration and molar ratio between surfactant template and silane) were optimised to form a thin and permeable film likely to be used in preconcentration electroanalysis. The morphology of the film electrodes were characterised by scanning electron microscopy. The permeability properties of the modified Pt µdisc electrodes have been evidenced by cyclic voltammetry using Ru(NH3)63+ as a redox probe. The best parameters identified for the film preparation are a current density of − 8 mA cm−2 applied for 15 s in a solution containing 110 mM of hydrolysed silane precursors and 70.4 mM of CTAB. Pt µdisc electrodes modified in these conditions were used for the open‐circuit preconcentration of Hg(II) species prior to their detection by anodic stripping voltammetry in a mercury‐free solution. In the optimized conditions, a sensitivity of 14.3 mA cm−2 µM−1 was obtained for the 0.02–0.08 µM concentration range. The analytical performance of such organosilica films could decay by up to two orders of magnitude for the materials prepared in conditions other than the optimized ones, highlighting the need for a fine control of the deposition parameters to elaborate sensors based on such modified ultramicroelectrodes.
Equivalent force control method for substructure pseudo‐dynamic test of a full‐scale masonry structure
Authors: Chen Zaixian , Xu Guoshan , Wu Bin , Sun Yongtao , Wang Huanding , Wang Fenglai 
Published: October 2013

SUMMARYThe effectiveness of equivalent force control (EFC) method has been experimentally validated through hybrid tests with simple specimens. In this paper, the EFC method is applied for the MDOF pseudo‐dynamic substructure tests in which a three‐storey frame‐supported reinforced concrete masonry shear wall with full scale is chosen as physical substructure. The effects of equivalent force controller parameters on the response performance are studied. Analytical expressions for the controller parameter ranges are derived to avoid response overshooting or oscillation and are verified by numerical simulation. The controller parameters are determined based on analytical and numerical studies and used in the actual full‐scale pseudo‐dynamic test. The test results show good tracking performance of EFC, which indicates a successful test. Copyright © 2013 John Wiley & Sons, Ltd.
Optimal channel sensing maximising sum rate in cognitive radio with multiple secondary links
Authors: Yu Heejung 
Published: October 2013

ABSTRACTThe channel sensing problem maximising the sum rate of primary and secondary users in cognitive radio networks is considered. Previously, the optimal sensing characteristics, that is false alarm and detection probabilities, in cognitive radio with single secondary user were investigated. In this paper, we extend to cases with multiple secondary users, and the characteristics of a sum rate and the optimal sensing are investigated under a given primary activity factor. Additionally, the asymptotic behaviour of the optimal sensing point is examined as the number of secondary users increases under the round robin and p‐ALOHA multiple access schemes. It is shown that the optimal sensing point converges to a constant, which is determined by the primary activity factor, primary and secondary link qualities. Copyright © 2013 John Wiley & Sons, Ltd.
Efficient stochastic FEM for flow in heterogeneous porous media. Part 1: random Gaussian conductivity coefficients
Authors: Traverso L. , Phillips T.N. , Yang Y. 
Published: October 2013

SUMMARYThis paper is concerned with the development of efficient iterative methods for solving the linear system of equations arising from stochastic FEMs for single‐phase fluid flow in porous media. It is assumed that the conductivity coefficient varies randomly in space according to some given correlation function and is approximated using a truncated Karhunen–Loève expansion. Distinct discretizations of the deterministic and stochastic spaces are required for implementations of the stochastic FEM. In this paper, the deterministic space is discretized using classical finite elements and the stochastic space using a polynomial chaos expansion. The highly structured linear systems which result from this discretization mean that Krylov subspace iterative solvers are extremely effective. The performance of a range of preconditioned iterative methods is investigated and evaluated in terms of robustness with respect to mesh size and variability of the conductivity coefficient. An efficient symmetric block Gauss–Seidel preconditioner is proposed for problems in which the conductivity coefficient has a large standard deviation.The companion paper, herein, referred to as Part 2, considers the situation in which Gaussian random fields are transformed into lognormal ones by projecting the truncated Karhunen–Loève expansion onto a polynomial chaos basis. This results in a stochastic nonlinear problem because the random fields are represented using polynomial chaos containing terms that are generally nonlinear in the random variables. Copyright © 2013 John Wiley & Sons, Ltd.
Fabrication of Solid Oxide Fuel Cells with a Thin (La0.9Sr0.1)0.98(Ga0.8Mg0.2)O3–δ Electrolyte on a Sr0.8La0.2TiO3 Support
Authors: Miller E. C. , Gao Z. , Barnett S. A. 
Published: October 2013

AbstractThis paper describes Sr0.8La0.2TiO3 (SLT)‐supported solid oxide fuel cells with a thin (La0.9Sr0.1)0.98Ga0.8Mg0.2O3–δ (LSGM) electrolyte and porous LSGM anode functional layer (AFL). Optimized processing for the SLT support bisque firing, LSGM electrolyte layer co‐firing, and LSGM AFL colloidal composition is presented. Cells without a functional layer yielded a power density of 228 mW cm–2 at 650 °C, while cells with a porous LSGM functional layer yielded a power density of 434 mW cm–2 at 650 °C. Cells with an AFL yielded a higher open circuit voltage, possibly due to reduced Ti diffusion into the electrolyte. Infiltration produced Ni nanoparticles within the support and AFL, which proved crucial for the electrochemical activity of the anode. Power densities increased with increasing Ni loadings, reaching 514 mW cm–2 at 650 °C for 5.1 vol.% Ni loading. Electrochemical impedance spectroscopy analysis indicated that the cell resistance was dominated by the cathode and electrolyte resistance with the anode resistance being relatively small.
Synthesis and Characterization of the 2‐Methylaminopyridine‐functionalized Polystyrene Resin‐supported Pd(II) Catalyst for the Mizoroki–Heck and Sonogashira Reactions in Water
Authors: Bakherad Mohammad , Amin Amir Hosein , Gholipoor Farzaneh 
Published: October 2013

AbstractA new polystyrene‐anchored Pd(II) pyridine complex is synthesized and characterized. This Pd(II) pyridine complex behaves as a very efficient heterogeneous catalyst in the Heck reaction of methyl acrylate with aryl halides and the Sonogashira reaction of terminal alkynes with aryl halides in water. Furthermore, the catalyst shows good thermal stability and recyclability. This polymer‐supported Pd(II) catalyst could easily be recovered by simple filtration of the reaction mixture and reused for more than five consecutive trials without a significant loss in its catalytic activity.
How to resolve the caudal septal deviation?: Clinical outcomes after septoplasty with bony batten grafting
Authors: Chung Yong S. , Seol Jeong‐Hun , Choi Jee‐Min , Shin Dong‐Hyuk , Kim Yong W. , Cho Jae H. , Kim Jin K. 
Published: October 2013

Objectives/HypothesisCaudal septal deviation interrupts normal nasal breathing, due to the narrowing of the external valve area and nasal valve angle. In this study, we found a different approach for correction of caudal septal deviation with no associated deformity of the external nose.Study DesignIndividual case–control study.MethodsThe 39 patients completed questionnaires by interviews postoperatively for assessment of nasal obstruction. In addition, patients assessed the severity of their nasal symptoms (i.e., mouth breathing, mouth dryness, hyposmia, rhinorrhea, epistaxis, snoring, postnasal drip, and headache) preoperatively and postoperatively using a visual analog scale (VAS). Improvement in the treatment of nasal obstruction using a VAS and a questionnaire for subjective satisfaction were evaluated 3 months after septoplasty. To evaluate outcomes objectively, endoscopic photographs of the nasal cavity and acoustic rhinometry before and after surgery were evaluated. For comparison between preoperative and postoperative status, the Wilcoxon signed ranks test was used.ResultsPatients reported a significant decrease in the VAS severity of all nasal symptoms. The minimal cross‐sectional area (MCA1) of the convex side after vascular constriction using acoustic rhinometry showed significant widening. Patients were divided into a turbinoplasty group and a nonturbinoplasty group, and the turbinoplasty group showed a significant increase in both the convex side and concave side in MCA1 and in the convex side in the anterior portion of the inferior turbinate.ConclusionsEndonasal septoplasty using bony batten grafting for caudal septal deviation resulted in an improvement of nasal obstruction symptoms and acoustic rhinometry components.Level of Evidence3b Laryngoscope, 124:1771–1776, 2014
Director‐based beam finite elements relying on the geometrically exact beam theory formulated in skew coordinates
Authors: Eugster S.R. , Hesch C. , Betsch P. , Glocker Ch. 
Published: October 2013

SUMMARYIn the present work, a new director‐based finite element formulation for geometrically exact beams is proposed. The new beam finite element exhibits drastically improved numerical performance when compared with the previously developed director‐based formulations. This improvement is accomplished by adjusting the underlying variational beam formulation to the specific features of the director interpolation. In particular, the present approach does not rely on the assumption of an orthonormal director frame. The excellent performance of the new approach is illustrated with representative numerical examples. Copyright © 2013 John Wiley & Sons, Ltd.
Application of two‐dimensional gel‐based mass spectrometry to functionally dissect resistance to targeted cancer therapy
Authors: Klein Oliver , Rohwer Nadine , de Molina Katja Freitag , Mergler Stefan , Wessendorf Petra , Herrmann Marion , Klose Joachim , Cramer Thorsten 
Published: October 2013

PurposeThe majority of gastric cancers are diagnosed at advanced stages, characterized by robust therapy resistance. The oncoprotein hypoxia‐inducible factor 1 (HIF‐1) is associated with therapy resistance, partly via activation of the DNA damage response. We have noted a robust ability of gastric cancer cells to functionally compensate the loss of HIF‐1 in vitro. The purpose of this study was to identify molecular pathways that underlie this compensation.Experimental designWe performed 2DE to compare the nuclear proteome of wild‐type and HIF‐1‐deficient gastric cancer cells. Differently expressed protein spots were identified via MS). After bioinformatic evaluation, functional validation of selected identified pathways was performed.Results2DE displayed a total of 2523 protein spots, from which 87 were identified as regulated by HIF‐1. Seventy of the identified spots were different proteins and 17 were isoforms. Bioinformatic analyses revealed that a significant amount of the identified proteins were related to cellular survival pathways. Specifically, members of the proteasome pathway were found upregulated upon loss of HIF‐1. Combined inhibition of HIF‐1 and the proteasome inflicted significant DNA damage, supporting the hypothesis that the proteasome is of functional importance to compensate the loss of HIF‐1.Conclusions and clinical relevanceOur data show robust and functional changes of the nuclear proteome upon inactivation of the HIF‐1 oncoprotein in gastric cancer cells. We propose that 2DE‐MS represents a useful tool to functionally dissect resistance mechanisms to targeted therapy and to identify novel targets for antiproliferative combination therapy.