bluuebunny/crossref_metadata_2025_split huggingface dataset:
Humanitarian Aid Distribution in the Context of Human Rights-Based Approach Among Vulnerable Communities: Flash Floods and Climate Change in North Luwu, Indonesia
Authors: Ruslanjari Dina , Ramadhan Cahyadi , Al Hakim Inayah Bastin , Marsida Feby Aulia 
Published: August 2024

AbstractNorth Luwu Regency in South Sulawesi Province, Indonesia, was struck by a flash flood in 2020, resulting in 38 reported deaths and 106 people missing. Additionally, 20,562 residents were forced to evacuate and were referred to as internally displaced persons (IDPs). The handling and protection of the affected community or IDPs in an emergency and a post-emergency period requires proper, integrated, and measurable management. The research done in North Luwu Regency, employed a qualitative approach and was conducted through observation, in-depth interviews, and focus group discussions (FGDs) with heads of villages and the officials, religious and local traditional leaders, NGOs, related agencies, and the IDPs. The findings of this study indicate that the policies regarding aid provision during flash floods are considered quite comprehensive, given that the region experiences similar disasters frequently. The findings also suggest that the implementation of IDP protection is comprehensive but encounters some challenges, including hindered aid distribution due to difficult access to disaster-stricken areas, non-targeted and non-centralised aid distribution, as well as the ineffectiveness of the random system for temporary housing for IDPs. In terms of perception, the community expresses satisfaction with the government’s performance in providing humanitarian aid and logistics, resulting in tangible impacts. Furthermore, no discriminatory practices based on religion, ethnicity/race, gender, background, or economic status were found in the aid distribution.
Thoracolumbar injuries: operative treatment: indications, techniques, timing and implant removal. Current practice
Authors: Bloemers Frank , Jug Marko , Nau Christoph , Komadina Radko , Pape Hans Christoph , Wendt Klaus 
Published: August 2024

AbstractThe operative treatment of thoracolumbar fractures is a rapidly evolving improvement in the care of patients with this injury after trauma. This article describes the different techniques and principles. Considerations and methods of treatment are scientifically addressed and illustrated according to the classification and severity of the fracture pattern. The use of computer navigation and optimisation of minimally invasive techniques is inevitable. The timing of surgery as well the removal of the material after fracture healing are also discussed. The operative treatment of spinal fractures is emerging and there is still much more knowledge to gain.
Efficacy and outcomes of rescue screws in unstable pelvic ring injuries – A retrospective matched cohort study
Authors: Klingebiel Felix Karl-Ludwig , Kalbas Yannik , Klee Octavia , Long Anhua , Teuben Michel , Teuber Henrik , Halvachizadeh Sascha , Berk Till , Neuhaus Valentin , Pape Hans-Christoph , Pfeifer Roman 
Published: August 2024

Abstract
Purpose
The emergency treatment of unstable pelvic ring injuries is still a challenge and requires surgical and anesthesiological resuscitation. Emergency fixation of the unstable pelvic ring with percutaneous sacroiliac (SI) screws, also known as “Rescue Screws”, is an established treatment method. The aim of our study was to compare the outcome and complication rates of “Rescue Screws” with elective SI-screw fixations.

Methods
A 1:1 ratio nearest-neighbor matched, retrospective cohort study of trauma patients with acute pelvic ring injuries at a level one trauma center was performed. Patients ≥ 15 years, treated with SI-screw fixation were included. Exclusion criteria: pathologic fractures, missing consent and navigated procedures. The primary outcome parameters was defined as SI-screw revision operations. Patients were stratified according to treatment strategy (RS: Rescue Screws; EL: elective SI-screws).

Results
From 392 patients identified between 11/2014 and 08/2021, 186 met the inclusion criteria with 41 in the RS Group and 145 in the EL group. After matching, 41 patients were included in each group with similar baseline characteristics except persistent hemodynamic shock (RS: n = 22 (53.37%) vs. EL: n = 1 (4.3%), p < 0.001). Surgical characteristics were comparable in terms of instrumentation levels and insertion-sites. No significant differences were observed in the outcome parameters (revisions, reoperations, implant-associated complications, LOS and mortality) between both groups.

Conclusion
Treatment of unstable pelvic ring fractures with Rescue Screws appears as a feasible treatment option for emergency stabilization. Rescue Screws are not associated with elevated revision rates and increased complications rates. This minimally invasive technique enables safe emergency stabilization of the posterior pelvic ring. Prospective or randomized clinical trials are required to directly compare Rescue Screws with other competing emergency stabilization techniques.
Is patient-reported outcome after treatment of unstable pelvic ring injuries related to pelvic symmetry? A prospective study
Authors: Therrien Camryn C. , ten Duis Kaj , Banierink Hester , de Vries Jean-Paul P. M. , Reininga Inge H. F. , IJpma Frank F. A. 
Published: August 2024

Abstract
Purpose
To determine the relation between pelvic symmetry, as measured by the cross-measurement technique, and patient-reported outcome measures (PROMs) in terms of functional status and health-related quality of life.

Methods
In this prospective cohort study, X and Y measurements were taken according to the cross-measurement technique on AP radiographs of patients who were treated for an unstable pelvic ring injury in a level-1 trauma center. Patients completed PROMs at the time of admission (recalled pre-injury score) and one year following their injury, reporting their functional status with the Short Musculoskeletal Function Assessment (SMFA-NL), specifically the lower extremity dysfunction (LED), problems with daily activities (PDA) and mental and emotional problems (MEP) subscales, and quality of life with EuroQol-5D (EQ-5D). Subgroup analyses were also performed. PROMs were used to analyze the relation between pelvic symmetry and patient-reported outcome, using Spearman’s Rank correlation coefficients.

Results
A total of 130 patients (mean age 58 (SD18) years) with an unstable pelvic ring injury were included, of which 95 (73%) sustained type-B injuries and 35 (27%) type-C injuries. Sixty-three (49%) patients were treated operatively. The median pelvic symmetry ratio was 1.01 (IQR: 0.05). Weak or no correlations were found between the pelvic symmetry scores and the outcome measurements (Spearman’s correlation coefficients: LED r = 0.09; PDA r = 0.11; MEP r=-0.02; and EQ-5D r=-0.08). Subgroup analyses revealed no correlations.

Conclusions
No significant relation was found between pelvic symmetry, measured radiologically, and functional status and health-related quality of life, one year following an unstable pelvic ring injury.
Der Zusammenhang zwischen Adipositas, sozialer Isolation und psychischer Gesundheit – Ergebnisse der LIFE-Adult-Studie
Authors: Görres Charlyn , Hoßbach Jana , Pabst Alexander , Luppa Melanie , Stein Janine , Welzel Franziska D. , Jung Franziska U. , Hussenoeder Felix S. , Engel Christoph , Kirsten Toralf , Reyes Nigar , Wirkner Kerstin , Riedel-Heller Steffi G. , Löbner Margrit 
Published: August 2024

Zusammenfassung
Hintergrund
Bevölkerungsbasierte Studien zum Zusammenhang von sozialer Isolation und Adipositas, die auch jüngere Erwachsene einschließen, fehlen in Deutschland bisher. Ziel der vorliegenden Arbeit ist die Untersuchung der Prävalenzen sozialer Isolation bei Menschen mit und ohne Adipositas. Zudem werden sozial Isolierte mit und ohne Adipositas hinsichtlich soziodemografischer und sozioökonomischer Faktoren sowie depressiver Symptomatik untersucht.

Methoden
Grundlage waren die Baseline-Daten der LIFE-Adult-Studie (18–79 Jahre) aus dem Studienzeitraum 2011–2014. Die untersuchte Stichprobe umfasste n = 8350 Teilnehmende. Erhoben wurden neben soziodemografischen Charakteristika und dem sozioökonomischen Status (SES), Daten zur sozialen Isolation (LSNS-6), zu Depressivität (ADS) und Body-Mass-Index (BMI). Die Auswertungen erfolgten mittels inferenzstatistischer Analysen und linearer Regression.

Ergebnisse
Insgesamt waren 13,1 % der Gesamtstichprobe von sozialer Isolation betroffen. Teilnehmende mit Adipositas (20,4 %) wiesen eine signifikant (p < 0,001) höhere Prävalenz als jene ohne Adipositas auf (11,4 %). Eine bessere soziale Einbindung war signifikant mit jüngerem Alter (p < 0,001), weiblichem Geschlecht (p < 0,001), einem verheirateten (und zusammenlebenden) Familienstand (p < 0,001), einem höheren sozioökonomischen Status (p < 0,001) sowie einer geringeren depressiven Symptomatik (p < 0,001) assoziiert.

Diskussion
Ein höherer BMI ging nicht per se mit einer schlechteren sozialen Einbindung einher. Es zeigte sich jedoch, dass sozial isolierte Menschen mit Adipositas im Vergleich zu jenen ohne Adipositas eine besondere Risikogruppe für eine eingeschränkte psychische Gesundheit darstellen und eine doppelt so hohe Prävalenz von sozialer Isolation aufwiesen.
Navigating the transition: a multidisciplinary approach to inflammatory bowel disease in children
Authors: Raffaele A. , Ferlini C. M. , Fusi G. , Lenti M. V. , Cereda E. , Caimmi S. M. E. , Bertozzi M. , Riccipetitoni G. 
Published: August 2024

Abstract
Purpose
A multidisciplinary approach to Inflammatory Bowel Disease (IBD) has recently demonstrated a positive impact in pediatric patients, reducing dropout rates and facilitating the transition to adult care. Our study aims to evaluate how this approach influences disease activity, dropout rates, and transition.

Methods
We conducted a longitudinal observational study including all patients diagnosed with IBD during pediatric-adolescent age, with a minimum follow-up period of 12 months. For each patient, endpoints included therapeutic approach, need for surgery and transition features.

Results
We included 19 patients: 13 with Ulcerative Colitis (UC) and 6 with Crohn’s disease (CD). Most patients required multiple lines of therapy, with over 50% in both groups receiving biological drugs. Compliance was good, with a single dropout in each group (10, 5%). The need for surgery was significantly higher in the CD group compared to the UC group (16% vs. 7.7%, p < 0.01). Mean age at transition was significantly higher in the UC group compared to the CD group (19.2 ± 0.7 years SD vs. 18.3 ± 0.6 years SD, p < 0.05).

Conclusions
In our experience, the multidisciplinary approach to IBD in transition-age patients appears effective in achieving clinical remission, offering the potential to reduce therapeutic dropouts.
Akinetic crisis and withdrawal syndromes: guideline “Parkinson’s disease” of the German Society of Neurology
Authors: Pötter-Nerger Monika , Löhle Matthias , Höglinger Günter ,   German Parkinson‘s Guideline Group
Published: August 2024

AbstractThe akinetic crisis is a well-known, rare, potentially life-threatening condition in Parkinson’s disease with subacute worsening of akinesia, rigidity, fever, impaired consciousness, accompanying vegetative symptoms and transient dopa-resistance. The akinetic crisis was historically supposed to be a “withdrawal syndrome” in the sense of discontinuation of dopaminergic medication. Recently, other “withdrawal syndromes” as the specific “dopamine agonist withdrawal syndrome” or “deep brain stimulation withdrawal syndrome” have been described as emergency situations with specific subacute symptom constellations. All three conditions require immediate start of the adequate therapy to improve the prognosis. Here, the diagnostic criteria and treatment options of these three acute, severely disabling syndromes will be reported along the current guidelines of the German Parkinson Guideline Group.
Iron deficiency without anemia in children with newly diagnosed celiac disease: 1-year follow-up of ferritin levels, with and without iron supplementation
Authors: Ben-Ami Tal , Trotskovsky Anna , Topf-Olivestone Chani , Kori Michal 
Published: August 2024

AbstractIron deficiency (ID) without anemia is common in children with newly diagnosed celiac disease (CD). We aimed to assess the effect of iron supplementation versus no treatment on ferritin levels in newly diagnosed CD patients with ID adhering to a gluten-free diet (GFD). A retrospective review of children < 18 years, with low ferritin (≤ 10 ng/mL) and normal hemoglobin levels diagnosed between 12.2018 and 12.2021. We compared hemoglobin and ferritin levels between patients who received supplemental iron to those who did not. Data, including demographics, laboratory tests, and anthropometrics, were collected at baseline, and at 6 and 12 months following the initiation of the GFD. Adherence to GFD was assessed at each visit. Among 304 children diagnosed during the study period, 43 (14.1%) had iron deficiency anemia and 60 (19.7%) ID without anemia. Among children with ID, 29 (48%) were female, mean age 7.3 ± 3.9 years. Twenty-nine (48%) children received iron supplementation, and 31 (52%) did not. At the 12-month follow-up visit, tissue transglutaminase levels decreased significantly (p < 0.001), from a mean baseline level of 226.6 ± 47.8 to 34.5 ± 46 U/mL in children that received iron supplementation and from 234.2 ± 52.4 to 74.5 ± 88.7 U/mL in non-treated children, with no significant difference between the groups p = 0.22. Ferritin levels increased significantly (p < 0.001), from 9.0 ± 4.7 to 25.2 ± 20.8 ng/mL in patients who received supplementation and from 8.9 ± 3.8 to18.6 ± 9.5 ng/mL in patients who did not, with no significant difference between the groups (p = 0.46).Conclusion: Most children with newly diagnosed celiac disease and iron deficiency, who adhere to GFD, will normalize ferritin levels within 12 months without the need of iron supplementation.

What is Known:• Iron deficiency and iron deficiency anemia are common in newly diagnosed celiac disease.• Improved iron absorption may follow mucosal healing process in patients adhering to a strict gluten-free diet.

What is New:• This single-center, retrospective cohort study evaluated the effect of iron supplementation versus no treatment on ferritin levels in children with newly diagnosed celiac disease with iron deficiency adhering to a gluten-free diet.• Most children with newly diagnosed celiac disease and iron deficiency, who adhere to gluten-free diet, will normalize ferritin levels within 12 months without the need of iron supplementation.
Baseline systemic inflammatory indices and clinicopathological features to predict the outcome of acute tubulointerstitial nephritis
Authors: Dirim Ahmet Burak , Namazova Nazrin , Dirim Merve Guzel , Oto Ozgur Akin , Artan Ayse Serra , Hurdogan Ozge , Ozluk Yasemin , Yazici Halil 
Published: August 2024

Summary

Background
Acute tubulointerstitial nephritis (AIN) is an immune-mediated disorder that can cause acute kidney injury (AKI). We aimed to investigate the characteristics of patients with AIN and predictive factors for treatment response.

Material and methods
In this study, thirty-one patients diagnosed with AIN on kidney biopsy between 2006 and 2021 were included. Baseline clinical, histopathological, and laboratory findings, including complete blood count (CBC), creatinine, erythrocyte sedimentation rate, C‑reactive protein, C3, C4, systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and urinalysis were evaluated. Treatment response, mortality, and creatinine levels at the time of last follow-up were also noted.

Results
The median age was 46 years and 80.6% were female. Median baseline creatinine and proteinuria levels were 4.1 mg/dL and 0.84 gram/day. The median follow-up period was 14 months and 93.5% received immunosuppressives. End-stage kidney disease (ESKD) developed in five patients (16.1%). Renal recovery (creatinine < 1.4 mg/dL) was observed in 17 patients (54.8%). Higher degrees of interstitial fibrosis, tubular atrophy, granuloma formation, global glomerulosclerosis, and higher baseline hemoglobin levels, in addition to a longer interval between first symptom to initiation of immunosuppressives were associated with renal nonrecovery, statistically. Also, patients who progressed to ESKD had higher baseline hemoglobin (p = 0.033) and lymphocyte (p = 0.044) and lower PLR levels (p = 0.016), as well as higher degrees of global glomerulosclerosis (p = 0.014), interstitial fibrosis (p = 0.042), and tubular atrophy (p = 0.030).

Conclusion
Treatment response rates are low for AIN, which may lead to ESKD. Besides chronicity in histopathology specimens, higher baseline hemoglobin levels and lower platelet-to-lymphocyte ratio might be prognostic. Further studies should be conducted on new markers for AIN.
Exploring sex differences in collaborative virtual environments for participation equality and user experience
Authors: Yang Yifan , Zhang Sheng , Sun Xu , Zhang Xingyi , Sun Xiaotong , Jing Ying , Yang Canjun 
Published: August 2024

AbstractCommunication technology plays a crucial role in facilitating remote collaborative work. This study investigated sex differences in Perceived Participation Equality and User Experience across different communication formats, i.e., face-to-face communication, conventional video conferences, and Virtual Reality (VR). An empirical study was conducted involving 15 groups, each comprising three participants, who engaged in a decision-making task. A research model was developed to evaluate the interplay between perceived participation equality, empathy, and immersion. This model was employed across three communication conditions and included both male and female participants. These findings on sex differences in user experience could help create a connected, cohesive, and productive remote collaborative work environment.
Possibilities and challenges for converting waste biomass into fuel, feed, and fertilizer in Nepal
Authors: Kafle Sagar , Gyawali Manoj , Adhikari Sushil , Kropp Jürgen P. , Pradhan Prajal 
Published: August 2024

AbstractWaste biomass is mainly used conventionally, without being converted into valuable products in developing countries, e.g., Nepal, mainly due to a lack of proper conversion knowledge, infrastructure, and resource data. We assessed the amount of biomass at sub-national (geography, province, and district) levels in Nepal to explore its conversion possibilities and challenges. Our assessment includes waste biomass such as agriculture crop residues, municipal waste, livestock, and human waste. We identified their current utilization practices and discussed their conversion possibilities, focusing on fuel, feed, and fertilizers. We estimated that about 1.7–5.0 million tonnes (Mt) of pellet/briquette and biochar, 1.7–5.1 Mt of feed block, 129–387 million m3 of biogas, and 0.6–1.9 Mt of fertilizer can be produced in Nepal. The conversion of the waste biomass into valuable products can have significant environmental and economic benefits. Our findings can help authorities formulate appropriate policies and entrepreneurs to develop business plans for proper biomass utilization in Nepal at national and subnational levels.
Personalized computational electro-mechanics simulations to optimize cardiac resynchronization therapy
Authors: Capuano Emilia , Regazzoni Francesco , Maines Massimiliano , Fornara Silvia , Locatelli Vanessa , Catanzariti Domenico , Stella Simone , Nobile Fabio , Greco Maurizio Del , Vergara Christian 
Published: August 2024

AbstractIn this study, we present a computational framework designed to evaluate virtual scenarios of cardiac resynchronization therapy (CRT) and compare their effectiveness based on relevant clinical biomarkers. Our approach involves electro-mechanical numerical simulations personalized, for patients with left bundle branch block, by means of a calibration obtained using data from Electro-Anatomical Mapping System (EAMS) measures acquired by cardiologists during the CRT procedure, as well as ventricular pressures and volumes, both obtained pre-implantation. We validate the calibration by using EAMS data coming from right pacing conditions. Three patients with fibrosis and three without are considered to explore various conditions. Our virtual scenarios consist of personalized numerical experiments, incorporating different positions of the left electrode along reconstructed epicardial veins; different locations of the right electrode; different ventriculo-ventricular delays. The aim is to offer a comprehensive tool capable of optimizing CRT efficiency for individual patients. We provide preliminary answers on optimal electrode placement and delay, by computing some relevant biomarkers such as $$dP/dt_{max}$$

d
P
/
d

t

max

, ejection fraction, stroke work. From our numerical experiments, we found that the latest activated segment during sinus rhythm is an effective choice for the non-fibrotic cases for the location of the left electrode. Also, our results showed that the activation of the right electrode before the left one seems to improve the CRT performance for the non-fibrotic cases. Last, we found that the CRT performance seems to improve by positioning the right electrode halfway between the base and the apex. This work is on the line of computational works for the study of CRT and introduces new features in the field, such as the presence of the epicardial veins and the movement of the right electrode. All these studies from the different research groups can in future synergistically flow together in the development of a tool which clinicians could use during the procedure to have quantitative information about the patient’s propagation in different scenarios.
Assessing climate change threats to biodiversity and protected areas of Iran
Authors: Rahimi Ehsan , Dong Pinliang , Ahmadzadeh Faraham , Jung Chuleui 
Published: August 2024

AbstractOur research endeavors to evaluate the precise ramifications of climate change on Iran’s protected regions, utilizing species distribution modeling to anticipate the effects of climate change on 394 bird species, 157 plant species, 72 reptiles, and 20 mammals across two climate change scenarios: SSP245 and SSP585 in 2070. Subsequently, we employed binary species distribution maps to determine the extent of overlap between 125 protected areas, 27 wildlife refuges, and 15 national parks and species distribution, quantifying the proportion of these areas encompassed by their distribution. We found that under the SSP585 scenario, 174 bird species could experience a 319% expansion in suitable habitats, while 220 species could decline by 57.1%. Among plants, 16 species are projected to grow by 40.3%, whereas 141 species may decrease by 68.8%. Reptiles could experience an increase of 279.1% in 24 species, with a 66.6% decrease in 48 species, while mammals may witness a significant increase of 147.3% in 5 species, but a 71.8% decrease in 15 species. Also, under the SSP585 scenario, in national parks, bird coverage declines from 32.2% (current) to 19.9%, plants from 24.2 to 13.2%, reptiles from 18.4 to 6.8%, and mammals from 17.7 to 10%. In wildlife refuges, birds decrease from 9.7 to 5.7%, plants from 10.9 to 4.6%, reptiles from 12.9 to 2.5%, and mammals from 7.4 to 4.3%. In protected areas, birds drop from 29.3 to 20.4%, plants from 27.7 to 12.5%, reptiles from 18.7 to 9.7%, and mammals from 24 to 12.1%. The low overlap of species with national parks, wildlife refuges, and protected areas underscores the importance of re-evaluating and potentially expanding protected areas to ensure they encompass a broader range of habitats, particularly those that are underrepresented, to enhance the conservation of Iran’s biodiversity amidst the challenges posed by climate change.