bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparing patients with cancer who work and treatment responsiveness
Authors: Kamau Caroline 
Published: September 2015

BackgroundMany patients with life-limiting illnesses continue to work because of financial reasons and because work provides good psychosocial support. A lack of appropriate advice/support through patient education could, however, make having a job detrimental to well-being (eg, symptom worsening).AimThis study investigated the frequency with which patients received information that empowers their understanding of their condition, treatment, side effects of treatment and the likely impact on occupational functioning.DesignA cross-sectional study.Setting/participantsAn analysis of survey data from 3457 patients with cancer in employment.ResultsLogistic regression showed that patients who received information about the impact of cancer on work life or education are 1.72 times more likely to have a positive treatment outcome. Patients who receive written information about the type of cancer are 1.99 times more likely to have a positive treatment outcome. Also, patients who receive written information before a cancer-related operation are 1.90 times more likely to have a positive treatment outcome. Information about the side effects of cancer treatment produces worse odds of a positive treatment outcome (0.65–1). A stepwise logistic regression analysing the effects irrespective of current employment status in 6710 patients showed that preparing them produces nearly twice better odds of cancer treatment responsiveness.ConclusionsPalliative care teams should consider ways of actively advising patients who work. Whereas the results showed evidence of good practice in cancer care, there is a need to ensure that all working patients with potentially life-limiting illnesses receive similar support.
Cardiovascular and selected comorbidities in early arthritis and early spondyloarthritis, a comparative study: results from the ESPOIR and DESIR cohorts
Authors: Gherghe Ana Maria , Dougados Maxime , Combe Bernard , Landewé Robert , Mihai Carina , Berenbaum Francis , Mariette Xavier , Wolterbeek Ron , van der Heijde Désirée 
Published: September 2015

ObjectivesTo investigate the prevalence of comorbidities in early rheumatoid arthritis (ERA) and early axial spondyloarthritis (ESpA) versus the general population.MethodsBaseline data of 689 patients with ERA from the Etude et Suivi des Polyarthrites Indifférenciées Récentes (ESPOIR) cohort (age 48.2±12.1 years, symptoms duration 14.2±14.5 weeks) and 645 patients with ESpA from Devenir des Spondylarthropathies Indifférenciées Récentes (DESIR; age 32.8±8.4 years, axial symptoms duration 79.0±45.7 weeks) were analysed. Metabolic and cardiovascular diseases (CVD), infections and neoplasia were determined in each cohort. The prevalence (95% CI) of several comorbidities was compared with that in the French general population. For patients without CVD, the 10-year risk of developing CVD was calculated using the Framingham and SCORE equations. The heart age was calculated using the 2008 Framingham points system.Results42% of patients with ERA and 20.3% of patients with ESpA had at least 1 comorbidity; the most common were arterial hypertension (AHT) and dyslipidaemia. AHT prevalence (95% CI) in ERA (18.2% (15.5% to 21.3%)), but not in ESpA (5.08% (3.57% to 7.14%)), was significantly increased (p<0.05) compared with the general population (7.58%). Prevalence of tuberculosis history was higher in ERA (4.7% (3.3% to 6.6%)), and ESpA (0.99% (0.4% to 2.3%)) than in the general population (0.02%; both p<0.05). No differences were observed in malignancies, coronary heart disease or diabetes. In ERA, among patients without a history of CVD, an intermediate to high CVD risk was found. The heart age exceeded the real age by 4.1±9.6 years in ERA and by 2.1±7.0 years in ESpA (p<0.001).ConclusionsWe found an increased prevalence of AHT and tuberculosis history in ERA and ESpA, and an increased CVD risk. These results should prompt rheumatologists to check these comorbidities early in the disease.
Real-life assessment of the validity of patient global impression of change in fibromyalgia
Authors: Rampakakis Emmanouil , Ste-Marie Peter A , Sampalis John S , Karellis Angeliki , Shir Yoram , Fitzcharles Mary-Ann 
Published: September 2015

ObjectivesPatient Global Rating of Change (GRC) scales are commonly used in routine clinical care given their ease of use, availability and short completion time. This analysis aimed at assessing the validity of Patient Global Impression of Change (PGIC), a GRC scale commonly used in fibromyalgia, in a Canadian real-life setting.Methods167 fibromyalgia patients with available PGIC data were recruited in 2005–2013 from a Canadian tertiary-care multidisciplinary clinic. In addition to PGIC, disease severity was assessed with: pain visual analogue scale (VAS); Patient Global Assessment (PGA); Fibromyalgia Impact Questionnaire (FIQ); Health Assessment Questionnaire (HAQ); McGill Pain Questionnaire; body map. Multivariate linear regression assessed the PGIC relationship with disease parameter improvement while adjusting for follow-up duration and baseline parameter levels. The Spearman's rank coefficient assessed parameter correlation.ResultsHigher PGIC scores were significantly (p<0.001) associated with greater improvement in pain, PGA, FIQ, HAQ and the body map. A statistically significant moderate positive correlation was observed between PGIC and FIQ improvement (r=0.423; p<0.001); correlation with all remaining disease severity measures was weak. Regression analysis confirmed a significant (p<0.001) positive association between improvement in all disease severity measures and PGIC. Baseline disease severity and follow-up duration were identified as significant independent predictors of PGIC rating.ConclusionsDespite that only a weak correlation was identified between PGIC and standard fibromyalgia outcomes improvement, in the absence of objective outcomes, PGIC remains a clinically relevant tool to assess perceived impact of disease management. However, our analysis suggests that outcome measures data should not be considered in isolation but, within the global clinical context.
Lifestyle factors may modify the effect of disease activity on radiographic progression in patients with ankylosing spondylitis: a longitudinal analysis
Authors: Ramiro Sofia , Landewé Robert , van Tubergen Astrid , Boonen Annelies , Stolwijk Carmen , Dougados Maxime , van den Bosch Filip , van der Heijde Désirée 
Published: September 2015

ObjectivesTo investigate the complex relationship between inflammation, mechanical stress and radiographic progression in patients with ankylosing spondylitis (AS), using job type as a proxy for continuous mechanical stress.MethodsPatients from the Outcome in Ankylosing Spondylitis International Study were followed up for 12 years, with 2-yearly assessments. Two readers independently scored the X-rays according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Disease activity was assessed by the AS Disease Activity Score C reactive protein (ASDAS-CRP). The relationship between ASDAS and spinal radiographic progression was investigated with longitudinal analysis, with job type at baseline (physically demanding (‘blue-collar’) versus sedentary (‘white-collar’) labour) as a potential factor influencing this relationship. The effects of smoking status and socioeconomic factors were also investigated.ResultsIn total, 184 patients were included in the analyses (70% males, 83% human leucocyte antigen-B27 positive, 39% smokers, 48% blue-collar workers (65/136 patients in whom data on job type were available)). The relationship between disease activity and radiographic progression was significantly and independently modified by job type: In ‘blue-collar’ workers versus ‘white-collar’ workers, every additional unit of ASDAS resulted in an increase of 1.2 versus 0.2 mSASSS-units/2-years (p=0.014 for the difference between blue-collar and white-collar workers). In smokers versus non-smokers, every additional unit of ASDAS resulted in an increase of 1.9 versus 0.4 mSASSS-units/2-years.ConclusionsPhysically demanding jobs may amplify the potentiating effects of inflammation on bone formation in AS. Smoking and socioeconomic factors most likely confound this relationship and may have separate effects on bone formation.
Efficient Control and Communication Paradigms for Coarse-Grained Spatial Architectures
Authors: Pellauer Michael , Parashar Angshuman , Adler Michael , Ahsan Bushra , Allmon Randy , Crago Neal , Fleming Kermin , Gambhir Mohit , Jaleel Aamer , Krishna Tushar , Lustig Daniel , Maresh Stephen , Pavlov Vladimir , Rayess Rachid , Zhai Antonia , Emer Joel 
Published: September 2015

There has been recent interest in exploring the acceleration of nonvectorizable workloads with spatially programmed architectures that are designed to efficiently exploit pipeline parallelism. Such an architecture faces two main problems: how to efficiently control each processing element (PE) in the system, and how to facilitate inter-PE communication without the overheads of traditional shared-memory coherent memory. In this article, we explore solving these problems using triggered instructions and latency-insensitive channels. Triggered instructions completely eliminate the program counter (PC) and allow programs to transition concisely between states without explicit branch instructions. Latency-insensitive channels allow efficient communication of inter-PE control information while simultaneously enabling flexible code placement and improving tolerance for variable events such as cache accesses. Together, these approaches provide a unified mechanism to avoid overserialized execution, essentially achieving the effect of techniques such as dynamic instruction reordering and multithreading.
Our analysis shows that a spatial accelerator using triggered instructions and latency-insensitive channels can achieve 8 × greater area-normalized performance than a traditional general-purpose processor. Further analysis shows that triggered control reduces the number of static and dynamic instructions in the critical paths by 62% and 64%, respectively, over a PC-style baseline, increasing the performance of the spatial programming approach by 2.0 ×.
FDA Approval: Blinatumomab
Authors: Przepiorka Donna , Ko Chia-Wen , Deisseroth Albert , Yancey Carolyn L. , Candau-Chacon Reyes , Chiu Haw-Jyh , Gehrke Brenda J. , Gomez-Broughton Candace , Kane Robert C. , Kirshner Susan , Mehrotra Nitin , Ricks Tiffany K. , Schmiel Deborah , Song Pengfei , Zhao Ping , Zhou Qing , Farrell Ann T. , Pazdur Richard 
Published: September 2015

Abstract
On December 3, 2014, the FDA granted accelerated approval of blinatumomab (Blincyto; Amgen, Inc.) for treatment of Philadelphia chromosome–negative relapsed or refractory precursor B-cell acute lymphoblastic leukemia (R/R ALL). Blinatumomab is a recombinant murine protein that acts as a bispecific CD19-directed CD3 T-cell engager. The basis for the approval was a single-arm trial with 185 evaluable adults with R/R ALL. The complete remission (CR) rate was 32% [95% confidence interval (CI), 26%–40%], and the median duration of response was 6.7 months. A minimal residual disease response was achieved by 31% (95% CI, 25%–39%) of all patients. Cytokine release syndrome and neurologic events were serious toxicities that occurred. Other common (&gt;20%) adverse reactions were pyrexia, headache, edema, febrile neutropenia, nausea, tremor, and rash. Neutropenia, thrombocytopenia, and elevated transaminases were the most common (&gt;10%) laboratory abnormalities related to blinatumomab. A randomized trial is required in order to confirm clinical benefit. Clin Cancer Res; 21(18); 4035–9. ©2015 AACR.
RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors
Authors: Cheng Haiying , Zou Yiyu , Ross Jeffrey S. , Wang Kai , Liu Xuewen , Halmos Balazs , Ali Siraj M. , Liu Huijie , Verma Amit , Montagna Cristina , Chachoua Abraham , Goel Sanjay , Schwartz Edward L. , Zhu Changcheng , Shan Jidong , Yu Yiting , Gritsman Kira , Yelensky Roman , Lipson Doron , Otto Geoff , Hawryluk Matthew , Stephens Philip J. , Miller Vincent A. , Piperdi Bilal , Perez-Soler Roman 
Published: September 2015

Abstract
We identified amplification of RICTOR, a key component of the mTOR complex 2 (mTORC2), as the sole actionable genomic alteration in an 18-year-old never-smoker with lung adenocarcinoma. Amplification of RICTOR occurs in 13% of lung cancers (1,016 cases) in The Cancer Genome Atlas and at a similar frequency in an independent cohort of 1,070 patients identified by genomic profiling. In the latter series, 11% of cases harbored RICTOR amplification as the only relevant genomic alteration. Its oncogenic roles were suggested by decreased lung cancer cell growth both in vitro and in vivo with RICTOR ablation, and the transforming capacity of RICTOR in a Ba/F3-cell system. The mTORC1/2 inhibitors were significantly more active against RICTOR-amplified lung cancer cells as compared with other agents targeting the PI3K–AKT–mTOR pathway. Moreover, an association between RICTOR amplification and sensitivities to mTORC1/2 inhibitors was observed. The index patient has been treated with mTORC1/2 inhibitors that led to tumor stabilization for more than 18 months.
Significance: RICTOR amplification may define a novel and unique molecular subset of patients with lung cancer who may benefit from treatment with mTORC1/2 inhibitors. Cancer Discov; 5(12); 1262–70. ©2015 AACR.
This article is highlighted in the In This Issue feature, p. 1225
ПОШИРЕНІСТЬ ДЕЯКИХ ГЕЛЬМІНТОЗІВ У ЧЕРНІВЕЦЬКІЙ ОБЛАСТІ
Authors: Захарчук О.І. , Пішак В.П. , Кривчанська М.І. , Миронюк М.Б. 
Published: September 2015

<p class="MsoNormal" style="text-align: justify; text-indent: 25.0pt;"><em style="mso-bidi-font-style: normal;"><span style="font-size: 12.0pt; background: white; mso-ansi-language: RU;" lang="RU">Д</span></em><em style="mso-bidi-font-style: normal;"><span style="font-size: 12.0pt; background: white;">осліджено екологічні та епідеміологічні особливості аскаридозу, ентеробіозу та трихоцефальозу в різних регіонах Чернівецької області за 2013 рік та перше півріччя 2014 року. Висока захворюваність на гельмінтози зумовлюється низькою дегельмінтизацією населення та тварин, збільшенням кількості домашніх тварин, забрудненням навколишнього середовища стічними водами, які містять яйця глистів, відсутністю цілеспрямованої пропаганди щодо дотримання гігієнічних норм, міграцією населення та поширенням туризму у Чернівецькій області, вкрай низькою інформованістю про сучасні методи діагностики гельмінтозів (послуги місцевих лабораторій), не завжди своєчасним та адекватним лікуванням.<span class="apple-converted-space"> </span></span></em></p>
O léxico da série Law and Order: uma análise inicial baseada em corpus paralelo
Authors: Murad Carla Regina R. O. 
Published: September 2015

<p>O objetivo deste trabalho foi examinar legendas do seriado Law and Order e suas spinoffs, com o intuito de explorar seu potencial terminológico e terminográfico. A principal hipótese é a de que a autenticidade da linguagem usada pelos personagens da série pode constituir um corpus rico tanto em especificidades jurídicas quanto em linguajar policial. Os pressupostos teóricos adotados foram a noção de legendas como corpora de ficção para extração de terminologia (FROMM 2011), a existência de termos emprestados de áreas de especialidade que conferem maior realidade às séries de ficção (FROMM 2011) e a elaboração de vocabulário de especialidade via Linguística de Corpus (FROMM 2007). Um corpus paralelo contendo legendas de 396 episódios em inglês americano e suas respectivas traduções para o português brasileiro foi estudado por meio do programa de análise lexical Wordsmith Tools 5.0 (SCOTT 2010). O estudo possibilitou a identificação da linguagem de especialidade jurídico-policial, a emergência do campo semântico Crimes e a verificação de equivalências.</p>
Terminologia em seriados médicos: os procedimentos de tradução na legendagem
Authors: Collet Thaís , Emmel Ina 
Published: September 2015

<p>Este trabalho analisa os procedimentos de tradução da terminologia médica apresentada nas legendas em português do seriado ER, com base na Teoria Comunicativa de Cabré (1999), e os compara com os resultados de uma análise anterior do seriado House (COLLET 2012) com o objetivo de verificar qual o procedimento predominante. A análise, que se deteve a apenas um episódio do seriado ER e aos termos referentes a aparelhos e exames, revelou o predomínio de procedimentos de equivalência, assim como havia demonstrado a análise anterior de quatro episódios do seriado House (COLLET 2012), confirmando, portanto, a importância dos termos para representar o conhecimento especializado.</p>
Adequate Selection of a Therapeutic Site Enables Efficient Development of Collateral Vessels in Angiogenic Treatment With Bone Marrow Mononuclear Cells
Authors: Nemoto Masaru , Koyama Hiroyuki , Nishiyama Ayako , Shigematsu Kunihiro , Miyata Tetsuro , Watanabe Toshiaki 
Published: September 2015

Background
Induction of angiogenic mechanisms to promote development of collateral vessels is considered promising for the treatment of peripheral arterial diseases. Collateral vessels generally develop from preexisting arteriolar connections, bypassing the diseased artery. We speculated that induction of angiogenic mechanisms should be directed to such arteriolar connections to achieve efficient collateral development. The aim of this study was to verify this hypothesis using autologous transplantation of bone marrow mononuclear cells in the rabbit model of chronic limb ischemia.

Methods and Results
The left femoral artery was excised to induce limb ischemia in male rabbits. In this model, arteriolar connections in the left coccygeofemoral muscle tend to develop into collateral vessels, although this transformation is insufficient to alleviate the limb ischemia. In contrast, arteriolar connections in the closely located adductor muscle do not readily develop into collateral vessels. At 21 days after ischemia initiation, a sufficient number of automononuclear cells were selectively injected in the left coccygeofemoral muscle (coccygeo group) or left adductor muscle (adductor group). Evaluation of calf blood pressure ratios, blood flow in the left internal iliac artery, and angiographic scores at day 28 after injection revealed that collateral development and improvement of limb ischemia were significantly more efficient in the coccygeo group than in the adductor group. Morphometric analysis of the coccygeofemoral muscle at day 14 showed similar results.

Conclusions
Specific delivery of mononuclear cells to the coccygeofemoral but not the adductor muscle effectively improves collateral circulation in the rabbit model of limb ischemia and suggests that adequate site selection can facilitate therapeutic angiogenesis.
Extratropical Cyclones in Idealized Simulations of Changed Climates
Authors: Pfahl Stephan , O’Gorman Paul A. , Singh Martin S. 
Published: September 2015

Abstract
Cyclones are a key element of extratropical weather and frequently lead to extreme events like wind storms and heavy precipitation. Understanding potential changes of cyclone frequency and intensity is thus essential for a proper assessment of climate change impacts. Here the behavior of extratropical cyclones under strongly varying climate conditions is investigated using idealized climate model simulations in an aquaplanet setup. A cyclone tracking algorithm is applied to assess various statistics of cyclone properties such as intensity, size, lifetime, displacement velocity, and deepening rates. In addition, a composite analysis of intense cyclones is performed. In general, the structure of extratropical cyclones in the idealized simulations is very robust, and changes in major cyclone characteristics are relatively small. Median cyclone intensity, measured in terms of minimum sea level pressure and lower-tropospheric relative vorticity, has a maximum in simulations with global mean temperature slightly warmer than present-day Earth, broadly consistent with the behavior of the eddy kinetic energy analyzed in previous studies. Maximum deepening rates along cyclone tracks behave similarly and are in agreement with linear quasigeostrophic growth rates if the effect of latent heat release on the stratification is taken into account. In contrast to moderate cyclones, the relative vorticity of intense cyclones continues to increase with warming to substantially higher temperatures, and this is associated with enhanced lower-tropospheric potential vorticity anomalies likely caused by increased diabatic heating. Moist processes may, therefore, lead to the further strengthening of intense cyclones in warmer climates even if cyclones weaken on average.
Asymmetric Estuarine Responses to Changes in River Forcing: A Consequence of Nonlinear Salt Flux
Authors: Chen Shih-Nan 
Published: September 2015

AbstractA linear theory for estuarine adjustment to river forcing as put forth by MacCready is extended to allow for quantification of nonlinear salt flux induced by gravitational exchange flow. It has been shown that, under a steplike change of river forcing, the estuarine responses are asymmetric, with the salinity field adjusting faster during the rising discharge. The asymmetry arises because the up-estuary salt flux due to exchange flow is a nonlinear function of estuarine length ∝ L−3. During the rising discharge, the estuary is longer, and the salt flux is comparatively less sensitive to the length variations. As a result, the up-estuary salt transport cannot keep pace with the rate of discharge changes, leading to a larger net salt flux and thus a shorter response time. A simple theory accounting for the nonlinear effect is then applied to Hudson-like systems and shown to capture the asymmetric response. The asymmetry is generalizable to other estuarine regimes where up-estuary salt fluxes are expressed as nonlinear power laws.
Small Intestinal Submucosa Implantation for the Possible Treatment of Vocal Fold Scar, Sulcus, and Superficial Lamina Propria Atrophy
Authors: Pitman Michael J. , Cabin Jonathan A. , Iacob Codrin E. 
Published: September 2015

Objectives: Evaluate the histologic effects of grafting porcine-derived small intestinal submucosa (SIS) into the vocal fold superficial lamina propria (SLP) layer for the potential treatment of vocal fold scar, sulcus and superficial lamina propria atrophy. Methods: Small intestinal submucosa was implanted into the right vocal fold SLP of 6 mongrel dogs. The left vocal fold served as a sham surgical control. At 2, 4, and 6 weeks postoperative, bilateral vocal fold specimens were evaluated histologically. Results: At 2 and 4 weeks, respectively, SIS-implanted vocal folds demonstrated moderate and mild inflammation and acute and chronic inflammation. At 6 weeks, inflammation was minimal and chronic. The 6-week specimens showed copious amounts of newly generated hyaluronic acid (HA) within the graft. There was no reactive fibrosis at 6 weeks. Conclusions: In the canine model, SIS appears safe for SLP grafting. Inflammation is similar to that of sham surgery. Small intestinal submucosa results in newly generated HA without concomitant fibrosis. Small intestinal submucosa has potential to be used in treatment of disorders with SLP, including vocal fold scar, sulcus, and atrophy. Studies evaluating the effect of SIS implantation on vocal fold function, as well as the ultimate fate of the graft, are required.