bluuebunny/crossref_metadata_2025_split huggingface dataset:
Borderline Personality Disorder and Post-traumatic stress disorder in adolescents: Protocol for a comparative study of Borderline Personality Disorder with and without comorbid Post-traumatic Stress Disorder (BORDERSTRESS- ADO)
Authors: Riou Maëlle , Duclos Harmony , Leribillard Méline , Parienti Jean Jacques , Segobin Shailendra , Viard Armelle , Apter Gisèle , Gerardin Priscille , GUILLERY Bérengère , Guénolé Fabian 
Published: August 2024

Abstract

Background
Borderline Personality Disorder (BPD) is a prevalent and debilitating psychiatric condition often accompanied by Post-Traumatic Stress Disorder (PTSD), with a substantial prevalence of trauma history among affected individuals. The clinical, cognitive, and cerebral parallels shared with PTSD suggest a trauma-related etiology for BPD. Studies consistently demonstrate a reduction in hippocampal volume in individuals with BPD, echoing findings in PTSD. However, the interpretation of this shared neurobiological profile remains contentious, with ongoing debates regarding the independence of these pathologies or the potential exacerbation of diminished hippocampal volume in BPD due to concurrent PTSD. Differential impacts on hippocampal subfields across both disorders may further complicate interpretation, suggesting the volume of hippocampal subfields as a potential discriminant biomarker. This study aims to characterize the multidimensional specific and shared profiles of BPD and PTSD-related alterations, with a particular emphasis on hippocampal subfields during adolescence, a crucial period in BPD development.
Methods
This study focuses on female adolescents, who are more prevalent in the BPD population. Participants are categorized into three groups: BPD, BPD with comorbid PTSD, and a control group of matched healthy individuals. Data collection encompasses clinical, cognitive, and neuroimaging domains commonly affected in both disorders, utilizing various imaging markers (including gray matter macrostructure, white matter microstructural integrity, and regional functional connectivity).
Discussion
This study examines adolescent BPD with and without comorbid PTSD on clinical, neuroimaging, and cognitive levels. It is the first to use a comprehensive multi-modal approach within the same sample. Additionally, it uniquely explores hippocampal subfield volume differences in adolescents. Analysis of the relationship between the investigated domains and the effects of PTSD comorbidity will elucidate specific and shared alteration profiles in both disorders.
Trial registration:
IDRCB number 2019-A00366-51 / clinicaltrials.gov ID: NCT0485274. Registered on 21/04/2021
Knowledge, Attitudes, and Practices of Patients with age-related macular degeneration (AMD) towards Anti-VEGF Treatment under One-stop Intravitreal Injection Model
Authors: Tan Liangzhang , Ma Zhiqiong , Miao Qi , Liu Shoukuan , Li Yongtao , Ke Yifeng , Ren Xinjun 
Published: August 2024

Abstract

To evaluate the knowledge, attitudes, and practices (KAP) of patients with age-related macular degeneration (AMD) regarding anti-VEGF treatment within a one-stop intravitreal injection service model. A cross-sectional study was conducted from July 1, 2023, to January 31, 2024, at the One-stop Intravitreal Injection Center at Tianjin Medical University Eye Hospital. Data were collected using a specially designed KAP questionnaire. The study successfully enrolled 493 participants. Of these, 214 (43.4%) were aged between 70 and 79 years, and 226 (45.8%) had been diagnosed with AMD for 1–3 years. The median knowledge, attitude, and practice scores were 6.00 [3.00, 8.00] (possible range: 0–9), 42.00 [37.00, 48.00] (possible range: 11–55), and 23.00 [18.00, 27.00] (possible range: 6–30), respectively. Multivariate logistic regression for practice showed that knowledge score (OR = 1.329, P < 0.001), attitude score (OR = 1.150, P < 0.001), aged 60–69 years (OR = 0.398, P = 0.022) were independently associated with proactive practice. Mediating effect significance showed that knowledge directly affected attitude (β = 0.625), knowledge (β = 0.398) and attitude (β = 0.503) directly affected practice (P < 0.001). Meanwhile, knowledge also indirectly affected practice through attitude (β = 0.315, P < 0.001). Regarding the factors impacting their selection of anti-VEGF treatment, 63.5% of patients emphasized the crucial role of its effectiveness. Additionally, over 40% of patients considered both family circumstances and insurance coverage to be highly significant in their decision-making process. This study found that patients with AMD exhibit suboptimal knowledge yet hold positive attitudes and engage actively in practices concerning anti-VEGF treatment within a one-stop intravitreal injection service model. It is recommended that healthcare providers enhance educational interventions at intravitreal injection centers to boost patient knowledge, which is likely to further improve attitudes and proactive management practices among AMD patients.
The Effect of Parental Autonomy Support on School-aged Children’ s School Adjustment: The Longitudinal Mediating Effect of Executive Function
Authors: Hu Xia , Li Zhu , Xing Xiaopei 
Published: August 2024

Abstract

Objective: To examine the relationship between parental autonomy support and school-aged children’s adjustment in four major domains of school and the longitudinal mediating role of children’s executive function.
Methods: The Psychological Autonomy Support Scale, Behavior Rating Inventory of Executive Function-2 and the Primary School Students’ Psychological Suzhi Measure were used as instruments for three short-term follow-ups with 476 school-aged children and their parents.
Results: (1) Paternal autonomy support could predict the four dimensions of school adjustment significantly and positively, whereas maternal autonomy support only had a positive effect on interpersonal adjustment; (2) The intercept and slope of children’s executive function positively predicted the four dimensions of school adjustment; (3) The “initial level” of children’s executive function fully mediated the relationships between paternal autonomy support and school adjustment, while the“
rate of development” of executive function did not.
Conclusions: Those parental autonomy supportive behavior targeting to improving children’s executive function will be particularly helpful to contribute to children’s school adjustment.
Comparison of slip-compensated odometry for various skid-steer suspensions on different ground surfaces.
Authors: Chlebowicz Łukasz , Cybulski Bartłomiej , Botew Piotr , Granosik Grzegorz 
Published: August 2024

Abstract

Localization systems for mobile robots often integrate various positioning methods, with wheel odometry commonly employedin predictive stages of position estimation algorithms. Reinforced odometry can elevate overall accuracy, robustness, andredundancy of a localization system. This study introduces a methodology and experiment comparing slip-compensatedodometry using four algorithms based on enhanced kinematic models of skid steer suspension. The primary objective isto extrapolate these methods to diverse skid-steer suspensions for enhanced adaptability and modular performance, whilethe secondary goal is to increase odometry robustness using low-cost methods. Through the evaluation of algorithmicperformance across 10 distinct surface types, characterized by diverse slipping conditions, we aimed to determine theiradaptability to different traction conditions. This paper introduces a slip compensation method for modular robotic platforms,comparing four odometry algorithms across 24 suspension configurations and 10 surfaces. It enhances odometry accuracyand slip compensation efficiency, focusing on reducing Mean Absolute Error (MAE) and demonstrating algorithm adaptability todifferent suspension types and surfaces. In this extended study, experiments were conducted involving 24 distinct suspensionconfigurations, all employing skid-steer mechanics. The rigorous testing entailed multiple repetitions of two different trajectoriesacross 10 varied ground surfaces, amounting to a total of 1576 trials.
Prostate Cancer Prediction Model Based on Anoikis-Related Genes and Therapeutic Potential of BUB1 in Influencing Epithelial-Mesenchymal Transition
Authors: Luo Shuhang , Wang Haoran , Zhang Jiong , Hou Huimin , Wang Jianye , Liu Ming 
Published: August 2024

Abstract

Background
Prostate cancer is one of the most common malignancies among men worldwide. Anoikis is a form of programmed cell death that is potentially negatively correlated with tumor progression; however, its relationship with prostate cancer remains inconclusive.
Methods
The transcriptomic and clinical data for this study were obtained from the TCGA and GEO databases. The prediction model was established using univariate Cox, multivariate Cox, and LASSO regression. Receiver operating characteristic (ROC) curves determined the predictive performance, and the GEO database was used for external validation. Patients were stratified into different risk groups, and their prognoses were compared using Kaplan-Meier analysis. We also analyzed immune cell infiltration and sensitivity to immunotherapeutic drugs in prostate cancer patients. The BUB1 gene was selected for in vitro experimental validation.
Results
We constructed a prognostic risk prediction model using four ARGs: BUB1, PTGS2, RAC3, and IRX1. Patients in the high-risk group had worse overall survival than those in the low-risk group, with significant differences in immune cell infiltration, immune checkpoint expression, and sensitivity to immunotherapeutic drugs. Using NMF, we categorized TCGA prostate cancer patients into two subgroups, with cluster2 having better prognoses. Gene expression and immune cell infiltration were compared between the subgroups. Knocking down the BUB1 gene in PC3 and C4-2 cell lines reduced prostate cancer cell proliferation and invasion and altered EMT-related protein expression.
Conclusion
After external validation, our study shows that the ARG-based predictive model accurately forecasts prostate cancer prognosis. In vitro experiments revealed that the BUB1 gene significantly affects prostate cancer cell proliferation, invasion, and the expression of specific EMT-related proteins. Thus, BUB1 is a potential therapeutic target.
Effects of a 16-week High-Speed Resistance Training program on physical and cognitive function in community-dwelling independent older adults: A Clinical Trial
Authors: Martins Alexandre Duarte , Batalha Nuno , Fernandes Orlando , Gonçalves Bruno , Oliveira Rafael , Brito João Paulo 
Published: August 2024

Abstract

Purpose: Ageing involves diverse changes in physical and cognitive functions. This study explored the impact of a 16-week High-Speed Resistance Training (HSRT) program on physical and cognitive functions of independent older adults.
Methods: The clinical trial involved 79 older adults, divided into an intervention group (IG, N=40, 68.50±3.54 years; 68.65±11.36 kg) and a control group (CG, N=39, 72.08±5.89 years; 67.04±10.69 kg). The IG participants engaged in 60–70 minutes session of supervised HSRT (speed range of >1.3–0.75 m/s in concentric actions), three times a week for 16 weeks, with 5–6 exercises per session, 2–3 sets, and 6–10 repetitions per exercise. Physical function was assessed using the chair‐stand test, the Time Up and Go (TUG) test, the seated medicine ball throw (SMBT), the six-minute walking test (6MWT), and handgrip strength test (dominant and non-dominant). The cognitive function was assessed using the Mini-Mental State Examination (MMSE). CG did not perform any exercise training program.
Results: The HSRT program could induce significant improvements in physical function in favour of the IG for chair-stand (η²p=0.736), TUG test (η²p=0.635), SMBT (η²p=0.331), 6MWT (η²p=0.386), and handgrip strength test for the dominant (η²p=0.448) and non-dominant side (η²p=0.388), as well as in cognitive function (η²p=0.248).
Conclusion: The 16-week HSRT program led to substantial enhancements in both physical and cognitive functions. Remarkably, the HSRT program, tailored to specific velocity zones, proved to be a safe and motivational approach to physical activity for this population.
Clinical Trial Registration
NCT05586087
The effect of the Global Diet Quality Score (GDQS)-based diet on glycemic control , mental health and quality of life in patients with type 2 diabetes: a randomized controlled clinical trial
Authors: Bagherpour Sara , Nourinezhad Fatemeh , Namiranian Nasim , Afkhami-Ardekani Mohammad , Nadjarzadeh Azadeh , Jambarsang Sara , Khayyatzadeh Sayyed Saeid 
Published: August 2024

Abstract

Background
As the most common endocrine disorder, type 2 diabetes is the main cause of more than 4% of deaths worldwide, West Asia and especially Iran is known as one of the regions in the world where the incidence of diabetes has increased significantly in recent years. Failure to control diabetes can cause side effects which reduce the patient's quality of life and increase mental disorders and the mortality rate.So dietary interventions such as a GDQS-based diet may be effective in improving biochemical and blood biomarkers and reducing risk factors in patients with type 2 diabetes.
Methods
This is a randomized clinical trial that includes men and women patients with type 2 diabetes. In total, 94 patients with type 2 diabetes were selected based on the entry criteria. Then these patients are randomly assigned to receive the diet based on GDQS (N = 47) or the standard diet of diabetic patients (N = 47) for 12 weeks. The primary outcomes will be the assessment of blood biomarkers (HbA1C, FBS, TG, TC, HDL, LDL) and mental health including (depression, anxiety), sleep quality and quality of life. Anthropometric measurements such as height, weight, waist circumference, body fat percentage, skeletal muscle percentage, body mass index and blood pressure will be considered as secondary outcomes. All outcomes will be measured at the beginning and end (end of 12 weeks) of the study. participants ' adherence will be evaluated using a 3-day food record (2 normal days and one off day) every week.
Discussion
Prospective studies have shown that adherence to healthy eating guidelines, as reflected by higher dietary quality indices, is associated with a lower risk of type 2 diabetes.A common feature among all diets is the consumption of more fruits, vegetables, and whole grains.Thus, a diet that scores high on the GDQS is associated with relatively plant-based diets.Among the foods in the GDQS, high consumption of red and processed meat, refined grains, sugar-sweetened beverages, and potatoes, especially french fries is associated with a higher risk of type 2 diabetes. However, more studies on GDQS-based diets in other populations are needed to confirm its usefulness in various populations to predict non-communicable diseases.
Trial registration:
Iranian Registry of Clinical Trials (www.irct.ir) IRCT20210427051098N4.Prospectively registered on December 1, 2023.
Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in aneurysmal subarachnoid hemorrhage
Authors: Mao Jian , Bao Yun , Liu Fan , Ye Qiyun , Peng Junxiang , Nie Jing , Huang Lijun , Liao Yonghong , Xing Yiheng , Wu Dongyang , Wang Ke , Feng Wenfeng , Qi Songtao , Pan Jun , Qiu Binghui 
Published: August 2024

Abstract

The incidence of growth hormone deficiency (GHD) after aneurysmal subarachnoid hemorrhage (aSAH) is significantly higher than that of other neuroendocrine disorders, but the mechanism is still elusive. We used mass spectrometry to identify differentially expressed proteins in cerebrospinal fluid samples from a well-characterized cohort of patients. A total of 683 proteins were identified, including 39 upregulated proteins in the GHD group. ADAM9 was most highly associated with GHD. In vivo, ADAM9 colocalized with M1 microglia markers, GH and cognitive ability of mice decreased significantly, and microglia secreted ADAM9 significantly. ADAM9 regulates pyroptosis of GHRH neurons by the Mad2L2-JNK-caspase-1 pathway. Sorafenib inhibits ADAM9 secretion by microglia and improves GH levels and the cognitive ability of mice. This study found that the crosstalk between GHRH neurons and neuroglial cells in the hypothalamic arcuate nucleus, i.e., microglia, is an essential factor in the formation of GHD in aSAH. We propose that neutralization of ADAM9 production by microglia might be a potential therapy for GHD after aSAH.
Assessment of Sacroiliitis Using Zero Echo Time Magnetic Resonance Imaging: A Comprehensive Evaluation
Authors: Bayrak Yunus Emre , Özer Törehan , Anık Yonca , Balcı Sibel , Aydın Duygu , Şahin Nihal , Sönmez Hafize Emine 
Published: August 2024

Abstract

Objective The aim of this study was to assess the effectiveness of zero echo time (ZTE) MRI in identifying structural lesions in patients with enthesitis-related arthritis (ERA), a subset of juvenile idiopathic arthritis (JIA) known for frequent sacroiliac (SI) joint involvement. Conventional MRI pulse sequences often struggle to adequately visualize osseous and calcified tissues. Methods All MRI examinations were conducted using a 1.5 T scanner. The MRI protocol included standard sequences such as fat-suppressed axial T2-weighted, axial T1-weighted, coronal short tau inversion recovery (STIR), and axial T2-weighted sequences. In addition to conventional MRI, a ZTE sequence was employed. Low-dose CT (ldCT) served as the reference standard and was performed using a 640-multislice CT device. Structural lesions, including erosions, sclerosis, and changes in joint space, were compared between imaging modalities. Results A total of 20 patients were included in the study (12 boys, 8 girls), with a median age at diagnosis of 14.1 years. ZTE-MRI demonstrated similar sensitivity to ldCT in detecting erosion (7 vs 8, p = 0.707). The interclass correlation coefficient (ICC) between ldCT and ZTE-MRI was 0.993 (p < 0.001), indicating excellent agreement. Moreover, ZTE-MRI showed strong agreement with ldCT in detecting sclerosis (ICC = 0.954, p < 0.001) and changes in joint space (ICC = 0.998, p < 0.001). Conclusions ZTE imaging shows promise in providing sacroiliac joint visualization comparable to ldCT scans, thereby improving the detection of subtle erosion and sclerosis in these joints.
Influence of variable-depth groove texture on the friction and wear performance of GCr15–SiC friction pairs under water lubrication
Authors: Zhang Yusen , Long Wei , Qiao Yan , Gui Puteng , Yin Yuting , Qian Haifeng 
Published: August 2024

Abstract

Surface texturing is an effective method for enhancing tribological properties through the dynamic pressure effect and secondary lubrication mechanism. This study developed and evaluated a variable groove profile texture that enhanced the bearing capacity, reduced the shear friction, and achieved effective water lubrication of a GCr15 ball–SiC disk friction pair interface. Based on a structural design analysis, the coefficient of friction, wear characteristics, and triboelectric voltages produced by different disk textures were evaluated in a series of experiments using scanning electron microscope images and energy dispersive spectrometer. The results indicated that a groove profile slanted downward towards the outside of the disk provided the best comprehensive antifriction and anti-wear performance under the considered low- and medium-speed conditions. This texture enhanced the radial conduction of lubricant through the groove via the dynamic pressure effect and collected and expelled the abrasive particles generated during friction via centrifugal and gravity forces, reducing the quantity of abrasive particles at the interface and decreasing the coefficient of friction. The elevated contact stress and localized heat generated at the edge of the groove texture stimulated iron migration and tribochemical reactions at the interface, forming a dense, wear-resistant lubricant film that decreased the wear on the ball and disk surfaces. Finally, the variable-depth groove texture boosted the surface charge density generated at the contact interface, increased the capability of the surface to adsorb the lubricating water film, and thereby enhanced the antifriction and anti-wear performance of the lubricated friction pair system.
Verification of the efficiency coefficient of the welding process by the CMT welding method
Authors: Kolařík Ladislav , Kolaříková Marie , Gurčík Tomáš , Dlouhý Štěpán 
Published: August 2024

Abstract

In order to obtain results from simulations that are close to reality, it is necessary to correctly set the parameters of the welding process. One of them is the efficiency of the welding process. Currently, new modifications of MIG/MAG methods are being created, which are characterized by lower heat introduced into the material (smaller efficiency coefficient). The efficiency coefficient determined by the European standard EN 1011-1 is no longer accurate enough for simulations. Therefore, it is necessary to accurately determine the efficiency coefficient of the method even for the mentioned modified welding processes. An experiment of calorimetric measurement of the efficiency of the CMT process (Cold Metal Transfer - modification of the MIG/MAG method) was proposed. The specific heat capacity of the base material was accurately measured. Furthermore, a calorimetric measurement of the efficiency of the welding process was carried out on a flat sample (Bead on the plate method) and on a sample with a V-groove to simulate the treatment of welding surfaces. Accurate method efficiency values ​​were determined for different welding current settings and different V-groove depths. The geometric characteristics of the fusion faces in butt welds have a greater influence on the efficiency coefficient than the size of the welding current.
Effects of Transcatheter Atrial Septal Defect Closure in Elderly Patients with Long-Standing Persistent Atrial Fibrillation
Authors: Matsubara Yuki , Yamano Michiyo , Yamano Tetsuhiro , Nakamura Takeshi , Nakanishi Naohiko , Zen Kan , Shiraishi Hirokazu , Matoba Satoaki 
Published: August 2024

Abstract

Purpose
Although the safety and efficacy of transcatheter atrial septal defect (ASD) closure has been reported in elderly patients, postprocedural outcomes in elderly patients with long-standing persistent atrial fibrillation (AF) have not been fully assessed. The aim of this study was to elucidate the cardiac remodeling process and symptom improvement after transcatheter ASD closure in elderly patients with AF (AF-ASD) compared to those in sinus rhythm (SR-ASD).
Methods
We enrolled 52 patients aged > 70 years out of 253 consecutive patients who underwent transcatheter ASD closure. We retrospectively analyzed serial echocardiograms, New York Heart Association (NYHA) functional classification, and plasma brain natriuretic peptide (BNP) levels from baseline to 1 year after the procedure.
Results
With respect to the right-sided chambers, significant reverse remodeling began immediately after the procedure and continued in both groups up to 1 year after the procedure. Left ventricular augmentation was comparable in both groups. Left atrial volume increase was prominent in the AF-ASD group, with a statistically significant difference compared with the SR-ASD group from 2 days to 1 year after the procedure (all p < 0.05). NYHA functional classification improved in both groups. Plasma BNP levels decreased only in the AF-ASD group from baseline to 1 year (median value [interquartile range], 336.2 pg/mL [145.1–491.4] to 173.8 pg/mL [73.6–261.7], p = 0.032).
Conclusion
Transcatheter ASD closure is an effective treatment for heart failure in elderly patients with ASD and long-standing persistent AF.