bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anisotropic Curie temperature materials
Authors: Armstrong Jason N. , Hua Susan Z. , Chopra Harsh Deep 
Published: October 2012

AbstractExistence of anisotropic Curie temperature materials [E. R. Callen, Phys. Rev. 124, 1373 (1961); J. Appl. Phys. 32, S221 (1961)] is a longstanding prediction – materials that become paramagnetic at a lower temperature along certain crystal directions while remaining magnetically ordered in other directions up to a higher temperature. Validating Callen's theory, we show that all directions within the basal plane of monoclinic Fe7S8 (pyrrhotite) single crystal remain ordered up to 603 K while the c‐axis becomes paramagnetic at 225 K. Results prompt a re‐evaluation of existing magnetic materials with a focus on magnetic characteristics along different crystal orientations above instead of below the ordering temperatures. Theoretical guidelines for identifying new materials with large anisotropy of Curie temperature are also given, and analysis protocol to characterize them in a self‐consistent manner is discussed. Materials with such a large directional dependence of Curie temperature open the possibility for uniquely new devices and phenomena, including (spin) transport. magnified imageAnisotropic Curie temperature in pyrrhotite (Fe7S8). Notice the large difference in ordering temperature along basal plane (main graph) relative to the c‐axis (inset).
Role of Neuregulin-1/ErbB Signaling in Stem Cell Therapy for Spinal Cord Injury-Induced Chronic Neuropathic Pain
Authors: Tao Feng , Li Qun , Liu Su , Wu Haiying , Skinner John , Hurtado Andres , Belegu Visar , Furmanski Orion , Yang Ya , McDonald John W. , Johns Roger A. 
Published: October 2012

Abstract
Chronic neuropathic pain is a common and debilitating consequence of spinal cord injury (SCI). In a rat contusion injury model, we observed that chronic neuropathic pain is present on day 7 after SCI and persists for the entire 56-day observation period. However, currently available pain therapies are inadequate for SCI-induced neuropathic pain. In this study, we show that spinal transplantation of mouse embryonic stem cell-derived oligodendrocyte progenitor cells (OPCs) enhances remyelination in the injured spinal cord and reduces SCI-induced chronic neuropathic pain. Moreover, we found that SCI reduces the protein level of neuregulin-1 and ErbB4 in the injured spinal cord and that OPC transplantation enhances the spinal expression of both proteins after SCI. Finally, intrathecal injection of neuregulin-1 small interfering RNA, but not the control nontarget RNA, diminishes OPC transplantation-produced remyelination and reverses the antinociceptive effect of OPC transplantation. Our findings suggest that the transplantation of embryonic stem cell-derived OPCs is an appropriate therapeutic intervention for treatment of SCI-induced chronic neuropathic pain, and that neuregulin-1/ErbB signaling plays an important role in central remyelination under pathological conditions and contributes to the alleviation of such pain.
Mesenchymal Stem Cells and Endothelial Progenitor Cells Decrease Renal Injury in Experimental Swine Renal Artery Stenosis Through Different Mechanisms
Authors: Zhu Xiang-Yang , Urbieta-Caceres Victor , Krier James D. , Textor Stephen C. , Lerman Amir , Lerman Lilach O. 
Published: October 2012

Abstract
Endothelial progenitor cells (EPC) and mesenchymal stem cells (MSC) augment tissue repair but possess slightly different properties. How the cellular phenotype affects the efficacy of this approach in renovascular disease is incompletely understood. This study tested the hypothesis that EPC and MSC protect the poststenotic kidney by blunting different disease pathways. Peripheral blood EPC and adipose-derived MSC were expanded and characterized by cell surface markers (e.g., CD34/kinase insert domain receptor, or CD44/CD90). Single-kidney hemodynamics and function were assessed in pigs after 10 weeks of renal artery stenosis (RAS) treated 4 weeks earlier with an intrarenal infusion of vehicle (n = 7), EPC (RAS+EPC) or MSC (RAS+MSC) (both 10 × 106, n = 6), and normal controls (n = 7). Kidney disease mechanisms were evaluated ex vivo. The ability of EPC and MSC to attenuate endoplasmic reticulum (ER) stress was also studied in isolated ER and in tubular cells cocultured with EPC and MSC. Glomerular filtration rate in RAS was lower than controls, increased in RAS+EPC, and further improved in RAS+MSC, although both improved renal blood flow similarly. EPC prominently enhanced renal growth factor expression and decreased oxidative stress, while MSC more significantly attenuated renal inflammation, ER stress, and apoptosis. Furthermore, MSC induced a greater decrease in caspase-3 and CHOP expression in cultured tubular cells through mechanisms involving cell contact. EPC and MSC achieve a comparable decrease of kidney injury in RAS by different mechanisms, although MSC elicited slightly superior improvement of renal function. These results support development of cell-based approaches for management of renovascular disease and suggest cell selection based on the underlying pathophysiology of kidney injury.
Fibroblast Growth Factor Receptor Signaling Is Essential for Normal Mammary Gland Development and Stem Cell Function
Authors: Pond Adam C. , Bin Xue , Batts Torey , Roarty Kevin , Hilsenbeck Susan , Rosen Jeffrey M. 
Published: October 2012

Abstract
Fibroblast growth factor (FGF) signaling plays an important role in embryonic stem cells and adult tissue homeostasis, but the function of FGFs in mammary gland stem cells is less well defined. Both FGFR1 and FGFR2 are expressed in basal and luminal mammary epithelial cells (MECs), suggesting that together they might play a role in mammary gland development and stem cell dynamics. Previous studies have demonstrated that the deletion of FGFR2 resulted only in transient developmental defects in branching morphogenesis. Using a conditional deletion strategy, we investigated the consequences of FGFR1 deletion alone and then the simultaneous deletion of both FGFR1 and FGFR2 in the mammary epithelium. FGFR1 deletion using a keratin 14 promoter-driven Cre-recombinase resulted in an early, yet transient delay in development. However, no reduction in functional outgrowth potential was observed following limiting dilution transplantation analysis. In contrast, a significant reduction in outgrowth potential was observed upon the deletion of both FGFR1 and FGFR2 in MECs using adenovirus-Cre. Additionally, using a fluorescent reporter mouse model to monitor Cre-mediated recombination, we observed a competitive disadvantage following transplantation of both FGFR1/R2-null MECs, most prominently in the basal epithelial cells. This correlated with the complete loss of the mammary stem cell repopulating population in the FGFR1/R2-attenuated epithelium. FGFR1/R2-null MECs were partially rescued in chimeric outgrowths containing wild-type MECs, suggesting the potential importance of paracrine mechanisms involved in the maintenance of the basal epithelial stem cells. These studies document the requirement for functional FGFR signaling in mammary stem cells during development.
Architecting technology transitions: A sustainability‐oriented sociotechnical approach
Authors: Davis Kim , Mazzuchi Thomas , Sarkani Shahram 
Published: October 2012

AbstractAchieving sustainability involves complex processes of technology, people, institutions, and the environment. The sustainability challenge requires a combination of social, political, and technological efforts. This paper discusses processes for technological change in order to meet the sustainability challenge. These complex processes are found to be a suitable application for systems engineering and for systems architecture in particular. Based on a thorough review of the literature, an architecture framework is developed to support management of portfolios of sustainable technology projects. This architecture framework is validated through a case study process, providing enhancements and lessons learned. The full architecture framework construct and associated proposed implementation approaches are presented, demonstrating the need for and applicability of such systems engineering approaches to achieve sustainability. Lessons learned from case studies and development of representative architectures are also described. ©2012 Wiley Periodicals, Inc. Syst Eng 16
Integrated product‐service analysis using SysML requirement diagrams
Authors: Durugbo Christopher 
Published: October 2012

AbstractDuring the design of integrated products and services, such as in a product‐service system (PSS), an analysis of specific customer needs and the requirements to fulfil them is an important activity needed to determine value propositions based on the function, use, and result of products. Requirements modeling using the OMG Systems Modeling Language (OMG ™ ) offers a model‐based systems engineering approach to documenting the functionality, performance, and interfacing of systems. However, to use modeling languages, there is a need to understand how the language meets the needs of the modeled system or domain. Following an initial review and evaluation of attributes of PSSs and existing approaches to modeling a PSS, this article analyzes the SysML requirements diagrams–as a technique for analyzing PSS requirements. SysML was compared against existing approaches to PSS modeling using the identified PSS attributes. Case scenarios of PSSs in the automotive industry were also applied to evaluate the use of SysML requirement diagrams. The article concludes by discussing implications of SysML for PSS researchers and managers. ©2012 Wiley Periodicals, Inc. Syst Eng 15
Assessment as learning: Enhancing discourse, understanding, and achievement in innovative science curricula
Authors: Hickey Daniel T. , Taasoobshirazi Gita , Cross Dionne 
Published: October 2012

AbstractAn assessment‐oriented design‐based research model was applied to existing inquiry‐oriented multimedia programs in astronomy, biology, and ecology. Building on emerging situative theories of assessment, the model extends prevailing views of formative assessment for learning by embedding “discursive” formative assessment more directly into the curriculum. Three twenty‐hour curricula were designed and aligned to content standards, and three levels of assessments were developed and used to assess and enhance learning for each curriculum. These assessments included three or four informal “activity‐oriented” quizzes and discursive formative feedback rubrics supporting collective discourse, a “curriculum‐oriented” examination of individual conceptual understanding, and a “standards‐oriented” test measuring aggregated achievement of targeted standards. After two design‐research cycles, worthwhile scientific argumentation and statistically significant gains were attained for two of the three packages on the exam and test. Achievement gains were comparable to or larger than those of students in comparison classrooms. Many existing innovations could be enhanced and evaluated in this fashion; designing these strategies directly into innovations could have an even greater impact on discourse, understanding, and achievement. © 2012 Wiley Periodicals, Inc. J Res Sci Teach 49: 1240–1270, 2012
The Link Between HR Practices, Psychological Contract Fulfillment, and Organizational Performance: The Case of the Greek Service Sector
Authors: Katou Anastasia A. , Budhwar Pawan S. 
Published: October 2012

AbstractThe purpose of this study is to investigate the impact of human resource (HR) practices on organizational performance through the mediating role of psychological contract (expressed by the influence of employer on employee promises fulfillment through employee attitudes). The study is based on a national sample of 78 organizations from the public and private services sector in Greece, including education, health, and banking, and on data obtained from 348 employees. The statistical method employed is structural equation modeling, via LISREL and bootstrapping estimation. The findings of the study suggest that employee incentives, performance appraisal, and employee promotion are three major HR practices that must be extensively employed. Furthermore, the study suggests that the organization must primarily keep its promises about a pleasant and safe working environment, respectful treatment, and feedback for performance, in order for employees to largely keep their own promises about showing loyalty to the organization, maintaining high levels of attendance, and upholding company reputation. Additionally, the study argues that the employee attitudes of motivation, satisfaction, and commitment constitute the nested epicenter mediating construct in both the HR practices–performance and employer–employee promise fulfillment relationships, resulting in superior organizational performance. © 2012 Wiley Periodicals, Inc.
Strategic HRM: Transforming Its Responsibilities Toward Ecological Sustainability—The Greatest Global Challenge Facing Organizations
Authors: Parkes Carole , Borland Helen 
Published: October 2012

AbstractIf we are to move to a more sustainable world, all actorsÑincluding governments, organizations, communities, and individualsÑneed to play their part in committing to a shift in the way we live our lives. This conceptual article explores the challenges that face the human resource management (HRM) profession in moving to a strategic position that supports the requirements of the biophysical environment. We argue that this is becoming an imperative for the future survival and success of organizations large and small, and thus is likely to be a key “modus operandi” for HRM professionals in the future who are looking to embed ecological sustainability into their organizations. This article offers new insights into developing business strategies for ecological sustainability, highlighting the implications for strategic HRM activity through organizational effectiveness, leadership, values, and, ultimately, HRM processes and systems. © 2012 Wiley Periodicals, Inc.
What Can Situated Learning Theory Tell Us About Leading to Develop Organizational Learning Capabilities for Entrepreneurial Performance? Lessons from a Knowledge‐Intensive Small Firm
Authors: Theodorakopoulos Nicholas , Figueira Catarina 
Published: October 2012

AbstractAlthough the role of strategic leadership in developing organizational learning capabilities has been examined to a certain extent, the specific behaviors and mechanisms through which these capabilities are developed have not been adequately understood. Paucity of research in this direction is even more conspicuous in a small firm/entrepreneurship context, which has been linked to innovation, economic growth, and employment generation. Reporting on an ethnographic study of a knowledge‐intensive, growth‐oriented small firm, this article addresses this gap in the literature by integrating strategic leadership and organizational learning theory in an entrepreneurship context. In this undertaking, situated learning theory is used as the major analytical lens, to shed light on how strategic leadership can build organizational learning capabilities that underpin entrepreneurial performance in small firms. Finally, implications for situated learning theory as an organizational learning perspective and leadership practice in an entrepreneurship context are submitted. © 2012 Wiley Periodicals, Inc.
The Impact of Buddying on Psychological Capital and Work Engagement: An Empirical Study of Socialization in the Professional Services Sector
Authors: Nigah Neelam , Davis Ann J. , Hurrell Scott A. 
Published: October 2012

AbstractThis article reports on a study investigating the impact of new employees' satisfaction with buddying on work engagement and explores the role of psychological capital in mediating this relationship. The study took place within a professional services organization wherein data were collected from 78 graduate newcomers in receipt of buddying. Satisfaction with buddying was found to have a positive relationship to both work engagement and psychological capital. The satisfaction with the buddy/work engagement relationship was fully mediated by psychological capital, providing support for Saks & Gruman's (2011) socialization resources theory. The results underscore the valuable role buddying can play as part of organizational socialization from a positive organizational behavior perspective. The research contributes to the growing evidence that positively oriented human resource practices can develop personal resources of newcomers within organizations. Recommendations are made for how the organization can improve and build upon this resource, thus developing the psychological capital of newcomers. © 2012 Wiley Periodicals, Inc.
Synthesis of polyaniline nanocomposite and its application for chromium removal from aqueous solution
Authors: Esfandian Hossein , Jafari Mehdi , Alizadeh Mostafa , Rahmati Hooman Taher , Katal Reza 
Published: October 2012

AbstractThe aim of this research was to investigate the sorption characteristics of polyaniline coated on sawdust (PAn/SD) for the removal of Cr(VI) ions from aqueous solutions. The sorption of Cr(VI) ions was carried out by the batch method. Characterization of PAn/SD was done by FTIR and SEM. The optimum conditions of sorption were found to be a PAn/SD dose of 0.6 g in 100 mL of Cr(VI) solution (50 mg/L), a contact time of 20 min, pH 2, and a temperature of 20°C, Increased temperature had a negative effect on the removal efficiency. Three equations, that is Morris–Weber, Lagergren, and pseudo‐second‐order, were tested to track the kinetics of the removal process. The kinetic data indicated that the adsorption process was described by the Morris–Weber equation. The Langmuir, Freundlich, and Dubinin–Radushkevick models were used with sorption data to estimate sorption capacity, intensity, and energy. The data were fitted with the Freundlich model. The thermodynamic parameters ΔH, ΔS, and ΔG were evaluated. They showed that the adsorption of Cr(VI) onto PAn/SD was feasible, spontaneous, and exothermic under the studied conditions. For desorption of Cr(VI) adsorbed onto PAn/SD, aqueous NaOH was used; with it, 85% of the adsorbed Cr(VI) could be desorbed. J. VINYL ADDIT. TECHNOL., 2012. © 2012 Society of Plastics Engineers
Finding MicroRNA Targets in Plants: Current Status and Perspectives
Authors: Ding Jiandong , Zhou Shuigeng , Guan Jihong 
Published: October 2012

Abstract
MicroRNAs (miRNAs), a class of ∼20–24 nt long non-coding RNAs, have critical roles in diverse biological processes including development, proliferation, stress response, etc. With the development and availability of experimental technologies and computational approaches, the field of miRNA biology has advanced tremendously over the last decade. By sequence complementarity, miRNAs have been estimated to regulate certain mRNA transcripts. Although it was once thought to be simple and straightforward to find plant miRNA targets, this viewpoint is being challenged by genetic and biochemical studies. In this review, we summarize recent progress in plant miRNA target recognition mechanisms, principles of target prediction, and introduce current experimental and computational tools for plant miRNA target prediction. At the end, we also present our thinking on the outlook for future directions in the development of plant miRNA target finding methods.
One Decade of Development and Evolution of MicroRNA Target Prediction Algorithms
Authors: Reyes∼Herrera Paula H. , Ficarra Elisa 
Published: October 2012

Abstract
Nearly two decades have passed since the publication of the first study reporting the discovery of microRNAs (miRNAs). The key role of miRNAs in post-transcriptional gene regulation led to the performance of an increasing number of studies focusing on origins, mechanisms of action and functionality of miRNAs. In order to associate each miRNA to a specific functionality it is essential to unveil the rules that govern miRNA action. Despite the fact that there has been significant improvement exposing structural characteristics of the miRNA–mRNA interaction, the entire physical mechanism is not yet fully understood. In this respect, the development of computational algorithms for miRNA target prediction becomes increasingly important. This manuscript summarizes the research done on miRNA target prediction. It describes the experimental data currently available and used in the field and presents three lines of computational approaches for target prediction. Finally, the authors put forward a number of considerations regarding current challenges and future directions.
n-Alkane evidence for the onset of wetter conditions in the Sierra Nevada, California (USA) at the mid-late Holocene transition, ~ 3.0 ka
Authors: Street Joseph H. , Anderson R. Scott , Rosenbauer Robert J. , Paytan Adina 
Published: October 2012

Abstractn-Alkane biomarker distributions in sediments from Swamp Lake (SL), in the central Sierra Nevada of California (USA), provide evidence for an increase in mean lake level ~ 3000 yr ago, in conjunction with widespread climatic change inferred from marine and continental records in the eastern North Pacific region. Length distributions of n-alkane chains in modern plants growing at SL were determined and compared to sedimentary distributions in a core spanning the last 13 ka. As a group, submerged and floating aquatic plants contained high proportions of short chain lengths (< nC25) compared to emergent, riparian and upland terrestrial species, for which chain lengths > nC27 were dominant. Changes in the sedimentary n-alkane distribution over time were driven by variable inputs from plant sources in response to changing lake level, sedimentation and plant community composition. A shift toward shorter chain lengths (nC21,nC23) occurred between 3.1 and 2.9 ka and is best explained by an increase in the abundance of aquatic plants and the availability of shallow-water habitat in response to rising lake level. The late Holocene expansion of SL following a dry mid-Holocene is consistent with previous evidence for increased effective moisture and the onset of wetter conditions in the Sierra Nevada between 4.0 and 3.0 ka.
Dietary supplementation with fish gelatine modifies nutrient intake and leads to sex-dependent responses in TAG and C-reactive protein levels of insulin-resistant subjects
Authors: Picard-Deland Éliane , Lavigne Charles , Marois Julie , Bisson Julie , Weisnagel S. John , Marette André , Holub Bruce , Chu Eugene , Frohlich Jiri , Hill John S. , Jacques Hélène 
Published: October 2012

AbstractPrevious studies have shown that fish protein, as well as marine n-3 PUFA, may have beneficial effects on cardiovascular risk profile. The objectives of this study were to investigate the combined effects of fish gelatine (FG) and n-3 PUFA supplementation on (1) energy intake and body weight, (2) lipid profile and (3) inflammatory and CVD markers in free-living insulin-resistant males and females. Subjects were asked to consume, in a crossover study design with two experimental periods of 8 weeks each, an n-3 PUFA supplement and n-3 PUFA supplement plus FG (n-3 PUFA + FG). n-3 PUFA + FG led to an increase in protein intake and a decrease in carbohydrate intake compared with n-3 PUFA (P < 0·02) in males and females. Sex–treatment interactions were observed for TAG (P = 0·03) and highly sensitive C-reactive protein (hsCRP) (P = 0·001) levels. In females, n-3 PUFA reduced plasma TAG by 8 % and n-3 PUFA + FG by 23 %, whereas in males, n-3 PUFA reduced plasma TAG by 25 % and n-3 PUFA + FG by 11 %. n-3 PUFA increased serum hsCRP by 13 % and n-3 PUFA + FG strongly reduced hsCRP by 40 % in males, whereas in females, n-3 PUFA reduced serum hsCRP by 6 % and n-3 PUFA + FG increased hsCRP by 20 %. In conclusion, supplementation with FG may enhance the lipid-lowering effect of marine n-3 PUFA in females and beneficially counteract the effect of n-3 PUFA on serum hsCRP in males. Further studies are needed to identify the sex-dependent mechanisms responsible for the divergent effects of FG on TAG and hsCRP levels in females and males, respectively.