bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ocean State Forecast along Ship Routes: Evaluation Using ESSO-INCOIS Real-Time Ship-Mounted Wave Height Meter and Satellite Observations
Authors: Harikumar R. , Hithin N. K. , Balakrishnan Nair T. M. , Sirisha P. , Prasad B. Krishna , Jeyakumar C. , Nayak Shailesh , Shenoi S. S. C. 
Published: August 2015

AbstractOcean state forecast (OSF) along ship routes (OAS) is an advisory service of the Indian National Centre for Ocean Information Services (INCOIS) of the Earth System Science Organization (ESSO) that helps mariners to ensure safe navigation in the Indian Ocean in all seasons as well as in extreme conditions. As there are many users who solely depend on this service for their decision making, it is very important to ensure the reliability and accuracy of the service using the available in situ and satellite observations. This study evaluates the significant wave height (Hs) along the ship track in the Indian Ocean using the ship-mounted wave height meter (SWHM) on board the Oceanographic Research Vessel Sagar Nidhi, and the Cryosat-2 and Jason altimeters. Reliability of the SWHM is confirmed by comparing with collocated buoy and altimeter observations. The comparison along the ship routes using the SWHM shows very good agreement (correlation coefficient > 0.80) in all three oceanic regimes, [the tropical northern Indian Ocean (TNIO), the tropical southern Indian Ocean (TSIO), and extratropical southern Indian Ocean (ETSI)] with respect to the forecasts with a lead time of 48 h. However, the analysis shows ~10% overestimation of forecasted significant wave height in the low wave heights, especially in the TNIO. The forecast is found very reliable and accurate for the three regions during June–September with a higher correlation coefficient (average = 0.88) and a lower scatter index (average = 15%). During other months, overestimation (bias) of lower Hs is visible in the TNIO.
Comparison Between Ultrasonography-Guided Popliteal Sciatic Nerve Block and Spinal Anesthesia for Hallux Valgus Repair
Authors: Karaarslan Sermin , Tekgül Zeki Tuncel , Şimşek Esen , Turan Murat , Karaman Yücel , Kaya Ahmet , Gönüllü Mustafa 
Published: August 2015

Background: We aimed to compare the efficacy, postoperative pain scores, adverse effects, additional analgesic requirements, and patient satisfaction scores of ultrasonography-guided sciatic nerve block by popliteal approach with spinal anesthesia for hallux valgus correction surgery. Methods: Sixty patients scheduled for hallux valgus correction surgery were enrolled in this prospective randomized study. Unilateral spinal block was performed on patients in the spinal anesthesia group. Popliteal block group patients received popliteal sciatic nerve block with guidance by both nerve stimulator and ultrasonography. Durations of anesthetic and operative interventions and time until the initiation of surgery were recorded for both groups. Pain magnitude of the patients at the 2nd, 4th, 6th, 12th, and 24th hours following anesthetic interventions were assessed with a visual analog scale (VAS). Adverse effects such as postoperative urinary retention and postdural puncture headache were recorded. Also, patient satisfaction was recorded. Patients were interviewed by phone for anesthetic and operative complications at 72 hours postoperatively. Results: Spinal anesthesia group patients exhibited hypotension, bradycardia, postdural puncture headache, and urinary retention rates of 6.6%, 3.3%, 10%, and 3.3%, respectively. Popliteal block group patients showed none of these adverse effects. Moreover, VAS scores of the patients at the 2nd, 4th, 6th, and 12th hours were significantly lower ( P < .001, P = .003, P < .001, P <.001, respectively), postoperative first analgesic requirement times were significantly longer ( P < .001), and pain satisfaction scores were significantly higher ( P < .001) in the popliteal block group. Conclusion: Given the complications related to spinal anesthesia and its insufficiency to maintain analgesia postoperatively, we believe the preferred anesthetic method should be peripheral nerve blocks for hallux valgus correction surgeries. Level of Evidence: Level I, randomized prospective study.
A Clinical Home for Preexposure Prophylaxis
Authors: Hoffman Susie , Guidry John A. , Collier Kate L. , Mantell Joanne E. , Boccher-Lattimore Daria , Kaighobadi Farnaz , Sandfort Theo G. M. 
Published: August 2015

Background: One barrier to wider preexposure prophylaxis (PrEP) availability is uncertainty about the most appropriate providers and practice settings for offering PrEP. Methods: The authors conducted in-depth interviews with 30 clinicians—primary care and HIV specialists—in the New York City (NYC) region to explore issues related to PrEP rollout, including who should provide it and in what settings. Results: A diverse group favored offering PrEP in non-HIV specialty settings in order to reach high-risk HIV-negative individuals. Yet, for each clinical skill or ancillary service deemed important for providing PrEP—knowledge of the medications, ability to assess and counsel around sexual risk behavior, and ability to provide support for retention and medication adherence—participants were divided in whether they thought primary care providers/practices could achieve it. Five participants strongly favored providing PrEP in HIV care practices. Conclusion: Although there may be multiple “homes” for PrEP, implementation research is needed to identify the most effective delivery approaches.
Translating stem cell research to the clinic: a primer on translational considerations for your first stem cell protocol
Authors: O’Brien Timothy , Creane Michael , Windebank Anthony J. , Terzic Andre , Dietz Allan B. 
Published: August 2015

AbstractOver the last two decades, a new therapeutic paradigm has emerged which has changed the way debilitating diseases may be treated in the future. Instead of using small-molecule drugs and devices to ameliorate the symptoms of disease, clinicians may harness the therapeutic power of cells to regenerate and cure diseases which currently represent a major unmet medical need. Advancements in the scientific knowledge of stem cell biology, along with highly encouraging preclinical proof-of-concept studies, in the last several years have served as a launch pad for testing such therapeutics in humans with life-threatening diseases. However, translating basic research findings into human therapy has not been straightforward and has presented many scientific, clinical, and regulatory challenges for scientists and clinicians. In this article, we provide a guidance framework for investigators for the design of early-phase clinical studies using stem cell-based therapeutics. Furthermore, important trial parameters and design features which must be considered before regulatory submission of such studies are highlighted.
Neutrophil contributions to the induction and regulation of the acute inflammatory response in teleost fish
Authors: Havixbeck Jeffrey J , Rieger Aja M , Wong Michael E , Hodgkinson Jordan W , Barreda Daniel R 
Published: August 2015

Abstract
Neutrophils are essential to the acute inflammatory response, where they serve as the first line of defense against infiltrating pathogens. We report that, on receiving the necessary signals, teleost (Carassius auratus) neutrophils leave the hematopoietic kidney, enter into the circulation, and dominate the initial influx of cells into a site of inflammation. Unlike mammals, teleost neutrophils represent &lt;5% of circulating leukocytes during periods of homeostasis. However, this increases to nearly 50% immediately after intraperitoneal challenge with zymosan, identifying a period of neutrophilia that precedes the peak influx of neutrophils into the challenge site at 18 h after injection). We demonstrate that neutrophils at the site of inflammation alter their phenotype throughout the acute inflammatory response, and contribute to both the induction and the resolution of inflammation. However, neutrophils isolated during the proinflammatory phase (18 h after injection) produced robust respiratory burst responses, released inflammation-associated leukotriene B4, and induced macrophages to increase reactive oxygen species production. In contrast, neutrophils isolated at 48 h after infection (proresolving phase) displayed low levels of reactive oxygen species, released the proresolving lipid mediator lipoxin A4, and downregulated reactive oxygen species production in macrophages before the initiation of apoptosis. Lipoxin A4 was a significant contributor to the uptake of apoptotic cells by teleost macrophages and also played a role, at least in part, in the downregulation of macrophage reactive oxygen species production. Our results highlight the contributions of neutrophils to both the promotion and the regulation of teleost fish inflammation and provide added context for the evolution of this hematopoietic lineage.
Investigating trajectories of social recovery in individuals
with first-episode psychosis: A latent class growth analysis
Authors: Hodgekins Jo , Birchwood Max , Christopher Rose , Marshall Max , Coker Sian , Everard Linda , Lester Helen , Jones Peter , Amos Tim , Singh Swaran , Sharma Vimal , Freemantle Nick , Fowler David 
Published: August 2015

BackgroundSocial disability is a hallmark of severe mental illness yet individual
differences and factors predicting outcome are largely unknown.AimTo explore trajectories and predictors of social recovery following a
first episode of psychosis (FEP).MethodA sample of 764 individuals with FEP were assessed on entry into early
intervention in psychosis (EIP) services and followed up over 12 months.
Social recovery profiles were examined using latent class growth
analysis.ResultsThree types of social recovery profile were identified: Low Stable (66%),
Moderate-Increasing (27%), and High-Decreasing (7%). Poor social recovery
was predicted by male gender, ethnic minority status, younger age at
onset of psychosis, increased negative symptoms, and poor premorbid
adjustment.ConclusionsSocial disability is prevalent in FEP, although distinct recovery
profiles are evident. Where social disability is present on entry into
EIP services it can remain stable, highlighting a need for targeted
intervention.
Non-replication of the association between 5HTTLPR and response
to psychological therapy for child anxiety disorders
Authors: Lester Kathryn J. , Roberts Susanna , Keers Robert , Coleman Jonathan R. I. , Breen Gerome , Wong Chloe C. Y. , Xu Xiaohui , Arendt Kristian , Blatter-Meunier Judith , Bögels Susan , Cooper Peter , Creswell Cathy , Heiervang Einar R. , Herren Chantal , Hogendoorn Sanne M. , Hudson Jennifer L. , Krause Karen , Lyneham Heidi J. , McKinnon Anna , Morris Talia , Nauta Maaike H. , Rapee Ronald M. , Rey Yasmin , Schneider Silvia , Schneider Sophie C. , Silverman Wendy K. , Smith Patrick , Thastum Mikael , Thirlwall Kerstin , Waite Polly , Wergeland Gro Janne , Eley Thalia C. 
Published: August 2015

BackgroundWe previously reported an association between 5HTTLPR genotype and
outcome following cognitive–behavioural therapy (CBT) in child anxiety
(Cohort 1). Children homozygous for the low-expression short-allele
showed more positive outcomes. Other similar studies have produced mixed
results, with most reporting no association between genotype and CBT
outcome.AimsTo replicate the association between 5HTTLPR and CBT outcome in child
anxiety from the Genes for Treatment study (GxT Cohort 2,
n = 829).MethodLogistic and linear mixed effects models were used to examine the
relationship between 5HTTLPR and CBT outcomes. Mega-analyses using both
cohorts were performed.ResultsThere was no significant effect of 5HTTLPR on CBT outcomes in Cohort 2.
Mega-analyses identified a significant association between 5HTTLPR and
remission from all anxiety disorders at follow-up (odds ratio 0.45,
P = 0.014), but not primary anxiety disorder
outcomes.ConclusionsThe association between 5HTTLPR genotype and CBT outcome did not
replicate. Short-allele homozygotes showed more positive treatment
outcomes, but with small, non-significant effects. Future studies would
benefit from utilising whole genome approaches and large, homogenous
samples.
ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism
Authors: Castinetti F. , Brinkmeier M. L. , Mortensen A. H. , Vella K. R. , Gergics P. , Brue T. , Hollenberg A. N. , Gan L. , Camper S. A. 
Published: August 2015

AbstractISLET1 is a homeodomain transcription factor necessary for development of the pituitary, retina, motor neurons, heart, and pancreas. Isl1-deficient mice (Isl1−/−) die early during embryogenesis at embryonic day 10.5 due to heart defects, and at that time, they have an undersized pituitary primordium. ISL1 is expressed in differentiating pituitary cells in early embryogenesis. Here, we report the cell-specific expression of ISL1 and assessment of its role in gonadotropes and thyrotropes. Isl1 expression is elevated in pituitaries of Cga−/− mice, a model of hypothyroidism with thyrotrope hypertrophy and hyperplasia. Thyrotrope-specific disruption of Isl1 with Tshb-cre is permissive for normal serum TSH, but T4 levels are decreased, suggesting decreased thyrotrope function. Inducing hypothyroidism in normal mice causes a reduction in T4 levels and dramatically elevated TSH response, but mice with thyrotrope-specific disruption of Isl1 have a blunted TSH response. In contrast, deletion of Isl1 in gonadotropes with an Lhb-cre transgene has no obvious effect on gonadotrope function or fertility. These results show that ISL1 is necessary for maximal thyrotrope response to hypothyroidism, in addition to its role in development of Rathke's pouch.
A case of neonatal toxic shock syndrome-like exanthematous disease concurrent with maternal toxic shock syndrome
Authors: Honda Yoshitaka , Mizumoto Hiroshi , Hata Atsuko , Hata Daisuke 
Published: August 2015

AbstractBackground:Neonatal toxic shock syndrome-like exanthematous disease (NTED) and toxic shock syndrome (TSS) are both caused by the bacterial superantigen, toxic shock syndrome toxin-1 (TSST-1), which is mainly produced by methicillin-resistantStaphylococcus aureus(MRSA). However, the coincidence of NTED and maternal TSS has yet to be reported.Cases:A 4-day-old full-term infant showed a typical clinical profile and laboratory findings that matched the criteria for the diagnosis of NTED, resulting in complete remission after 7 days. Fever and a skin rash were observed in the mother of the infant 3 days postpartum. In both cases, marked expansion and activation of Vβ2+ T cells in the peripheral blood was confirmed by flow cytometry. Anti-TSST-1 antibody was not detected in the mother nor in the infant.Conclusion:Obstetricians should consider TSS for the differential diagnosis of puerperal fever and systemic erythema if the infant develops NTED.
Mathematical Modeling of Thin-Layer Solar Drying for Yarrow, Coriander and Hollyhock
Authors: Amanlou Yasaman , Tavakoli Hashjin Teymour , Ghobadian Barat , Najafi Gholamhassan 
Published: August 2015

Abstract
The objective of this study is to investigate the drying kinetics of Yarrow, Coriander and Hollyhock flowers. These three medicinal products were dried using a solar hybrid photovoltaic-thermal dryer. The drying process was examined at the air temperatures of 40°C, 50°C and 60°C and air velocities of 0.5, 1 and 1.5 m/s. The experimental drying data were fitted to different theoretical models to predict the drying kinetics. Nonlinear regression analysis was performed to relate the parameters of the model with the drying conditions. The performance of these models was evaluated by comparing the correlation coefficient (

R
2

$${R^2}$$

), root mean square error (RMSE) and the chi-square (

χ
2

$${\chi ^2}$$

) between the observed and the predicted moisture ratios. Among all the models, the exponential two-term was found to have the best fit in this study. Also the influence of plant type, air temperature and velocity was investigated.
Synthesis and properties of high temperature resistant and salt tolerant filtrate reducer N,N-dimethylacrylamide 2-acrylamido-2-methyl-1-propyl dimethyl diallyl ammonium chloride N-vinylpyrrolidone quadripolymer
Authors: Zhao Zhengguo , Pu Xiaolin , Xiao Luo , Wang Gui , Su Junlin , He Mingmin 
Published: August 2015

Abstract
N,N-dimethylacrylamide (DMAA), 2-acrylamido-2-methyl-1-propyl (AMPS), dimethyl diallyl ammonium chloride (DMDAAC) and N-vinylpyrrolidone (NVP) monomers were copolymerized to synthesize a zwitterionic copolymer filtrate reducer. The results of Fourier transform infrared (FTIR) spectroscopy and nuclear magnetic resonance (NMR) indicated that the molecular structure and chemical compositions of the quadripolymer matched with the design, and the result of the differential scanning calorimetry (DSC)-thermogravimetric analysis (TGA) showed that the polymer had good thermal stability. The effects of the quadripolymer on the properties and salt tolerance of drilling fluids were investigated. The environmental scanning electron microscope (ESEM) was used to observe the microstructure of the DMAA/AMPS/DMDAAC/NVP quadripolymer-bentonite system and filter cake of the drilling fluid added the copolymer. Results showed that a one space grid structure was formed by the molecular film with a hydrophobic association effect and electrostatic interaction between the groups in the positive and negative charges of the quadripolymer. It adsorbed and coated clay particles, and kept the particles distributing multilevels which contributed to forming a compact filter cake to reduce fluid loss. The spatial structure of the quadripolymer in drilling fluid could be destroyed partly by high temperatures, sodium and calcium, but the polymer still had a good effect on reducing fluid filtration.
UV-VIS Absorption Spectra of Molten AgCl and AgBr and of their Mixtures with Group I and II Halide Salts
Authors: Greening Giorgio G.W. 
Published: August 2015

AbstractThe UV-VIS absorption spectra of (Ag1-X[Li-Cs, Ba]X)Cl and of (Ag1-X[Na, K, Cs]X)Br at 823 K at the concentrations X=0.0, 0.1, 0.2 have been measured. The findings show that on adding the respective halides to molten silver chloride and silver bromide, shifts of the fundamental absorption edge to shorter wavelengths result. A correlation between the observed shifts and the expansion of the silver sub-lattice is found, which is valid for both silver halide systems studied in this work.
Synthesis and structural characterization of a novel copper(II)/lead(II) heterometallic organic–inorganic hybrid
Authors: Wang Gao-Feng , Zhang Xiao , Sun Shu-Wen , Yao Chen-Zhong , Liu Zhao-Rong , Wang Yu-Chun , Liu Yuan-Zhong 
Published: August 2015

Abstract
A new copper(II)/lead(II) complex [(terpy)3CuPb5Br12] (1) (terpy = 2,2′:6′,2″-terpyridine) has been synthesized and characterized by IR, elemental analysis, and single-crystal X-ray diffraction analysis. The copper(II) and lead(II) ions in the title complex are in distorted six- (Cu(II), Pb(II)) and eight-fold (Pb(II)) coordination environments, in which the donor atoms are provided by bromide anions and nitrogen atoms of the 2,2′:6′,2″-terpyridine ligands. Complex 1 contains [(terpy)4Pb9Br20]2– building blocks. These bromoplumbate(II) clusters are connected by (terpy)2Cu2Br4 units along the crystallographic b axis and by PbBr6 units along the a axis, thereby forming an extended sheet structure.
Large-Scale Phenotype-Based Antiepileptic Drug Screening in a Zebrafish Model of Dravet Syndrome
Authors: Dinday Matthew T. , Baraban Scott C. 
Published: August 2015

AbstractMutations in a voltage-gated sodium channel (SCN1A) result in Dravet Syndrome (DS), a catastrophic childhood epilepsy. Zebrafish with a mutation inscn1Labrecapitulate salient phenotypes associated with DS, including seizures, early fatality, and resistance to antiepileptic drugs. To discover new drug candidates for the treatment of DS, we screened a chemical library of ∼1000 compounds and identified 4 compounds that rescued the behavioral seizure component, including 1 compound (dimethadione) that suppressed associated electrographic seizure activity. Fenfluramine, but not huperzine A, also showed antiepileptic activity in our zebrafish assays. The effectiveness of compounds that block neuronal calcium current (dimethadione) or enhance serotonin signaling (fenfluramine) in our zebrafish model suggests that these may be important therapeutic targets in patients with DS. Over 150 compounds resulting in fatality were also identified. We conclude that the combination of behavioral and electrophysiological assays provide a convenient, sensitive, and rapid basis for phenotype-based drug screening in zebrafish mimicking a genetic form of epilepsy.
Informatics Systems and Tools to Facilitate Patient-centered Care Coordination
Authors: Kneale L. , Demiris G. 
Published: August 2015

Summary
Introduction: There is a growing international focus on patient-centered care. A model designed to facilitate this type of care in the primary care setting is the patient-centered medical home. This model of care strives to be patient-focused, comprehensive, team-based, coordinated, accessible, and focused on quality and safety of care.
Objective: The objective of this paper is to identify the current status and future trends of patient-centered care and the role of informatics systems and tools in facilitating this model of care. Methods: In this paper we review recent scientific literature of the past four years to identify trends and state of current evidence when it comes to patient-centered care overall, and more specifically medical homes.
Results: There are several studies that indicate growth and development in seven informatics areas within patient-centered care, namely clinical decision support, registries, team care, care transitions, personal health records, telehealth, and measurement. In some cases we are still lacking large randomized clinical trials and the evidence base is not always solid, but findings strongly indicate the potential of informatics to support patient-centered care.
Conclusion: Current evidence indicates that advancements have been made in implementing and evaluating patient-centered care models. Technical, legal, and practical challenges still remain. Further examination of the impact of patient-centered informatics tools and systems on clinical outcomes is needed.