bluuebunny/crossref_metadata_2025_split huggingface dataset:
36‐40% of Routine Care Patients With Osteoarthritis or Rheumatoid Arthritis Screen Positive for Anxiety, Depression, and/or Fibromyalgia on a Single MDHAQ
Authors: Schmukler Juan , Malfait Anne‐Marie , Block Joel A. , Pincus Theodore 
Published: July 2024

ObjectiveOsteoarthritis (OA) and rheumatoid arthritis (RA) are associated with similar patient disease burdens and a high prevalence of comorbid anxiety (ANX), depression (DEP), and fibromyalgia (FM). Nonetheless, these comorbidities are infrequently assessed in routine care, in part because multiple questionnaires are not feasibly completed by patients. We analyzed the prevalence of ANX, DEP, and FM in patients with OA versus patients with RA seen in routine care using indices within a single Multidimensional Health Assessment Questionnaire (MDHAQ) and associations with \ Routine Assessment of Patient Index Data 3 (RAPID3) and its component function, pain, and patient global scores.MethodsA retrospective analysis of MDHAQ data in unselected patients with OA or RA receiving routine care at one setting included four indices within an MDHAQ: MDHAQ ANX screen, MDHAQ DEP screen, Fibromyalgia Assessment Screening Tool, and RAPID3. The prevalence of each comorbidity and associations with RAPID3 and components were analyzed in unadjusted and age‐adjusted (Mantel‐Haenszel) odds ratios (ORs) and 95% confidence intervals.ResultsOverall, 40.4% of 361 patients with OA and 36.3% of 488 patients with RA screened positive for ANX, DEP, and/or FM (8.1% and 7% for all three, respectively). RAPID3 and each component were elevated significantly in patients with any positive screen result for ANX, DEP, and/or FM in both diagnoses (ORs of 2.6–35.8).ConclusionFM, DEP, and/or ANX rates were 40.4% in patients with OA and 36.3% in patients with RA, associated with significantly poorer patient status measures. Each of these three common comorbidities of patient distress may be feasibly screened for on a single MDHAQ in routine care.
One Meter Triboelectric Nanogenerator for Efficient Harvesting of Meter‐Scale Wave Energy
Authors: Chen Chunjin , Guo Dongxin , Tuo Liang , Wen Yongsheng , Li Jiawei , Qu Hang , Wen Honggui , Wan Lingyu , Liu Guanlin , Guo Hengyu 
Published: July 2024

AbstractTriboelectric nanogenerators (TENGs) are effective in harvesting high‐entropy low‐frequency wave energy, yet traditional TENGs struggle to align with the meter‐scale wavelengths prevalent in marine environments, significantly impairing their wave energy conversion efficiency. Addressing this, the One Meter TENG (OM‐TENG) is introduced, a pioneering advancement in TENG design that extends the shell size to 1 m. This innovation features a novel lantern‐shaped stacked silicon‐manganese steel sheet configuration, optimizing internal space usage, and achieving a single‐cycle transfer charge of 60.82 µC and a friction layer area density of 1.76 cm−1. Furthermore, by integrating a segmented limiter device for rational control of different sliders, effective contact separation among numerous TENG units is realized. Comprehensive evaluations through theoretical analysis, multiphysics field numerical simulations, sensor data analytics, and comparative experimental measurements have unequivocally demonstrated OM‐TENG's superior capability in capturing meter‐scale wave energy under actual environmental conditions, alongside its remarkable anti‐capsize performance. Achieving peak outputs of 584 V and 444 µA, OM‐TENG can power 96 2 W LEDs and drive wireless communication modules, marking a significant step forward in the efficient utilization of wave energy and the design of large‐scale TENGs.
A Straightforward Solvent‐Pair‐Enabled Multicomponent Coassembly Approach toward Noble‐Metal‐Nanoparticle‐Decorated Mesoporous Tungsten Oxide for Trace Ammonia Sensing
Authors: Jiang Fengluan , Deng Yu , Chen Keyu , Li Jichun , Huang Xin‐Yu , Zou Yidong , Wu Limin , Xie Wenhe , Deng Yonghui 
Published: July 2024

AbstractThe straightforward synthesis of noble‐metal‐nanoparticle‐decorated ordered mesoporous transition metal oxides remains a great challenge due to the difficulty of balancing the interactions between precursors and templates. Herein, a solvent‐pair‐enabled multicomponent coassembly (SPEMC) strategy is developed for straightforward synthesis of noble‐metal‐nanoparticle‐decorated nitrogen‐doped ordered mesoporous tungsten oxide (abbreviated as NM/N‐mWO3, NM = Pt, Rh, Pd). The amphiphilic poly(ethylene oxide)‐block‐polystyrene (PEO‐b‐PS) copolymers coassemble with ammonium metatungstate (AMT) clusters and different kinds of hydrophilic noble metal precursors without phase separation. SPEMC synthesis requires no direct interaction between PEO‐b‐PS and AMT, thus the assembly equilibriums between noble metal precursors and PEO‐b‐PS can be readily controlled. The obtained NM/N‐mWO3 nanocomposites possess ordered mesopores, abundant oxygen vacancies, and metal–metal oxide interfaces. As a result, the Pt/N‐mWO3 sensors exhibit superior ammonia sensing performances with high sensitivity, an ultralow limit of detection (51.2 ppb), good selectivity, and long‐term stability. Spectroscopic analysis reveals that ammonia is oxidized stepwise to NO, NO2−, and NO3− during the sensing process. Moreover, a portable wireless module based on Pt/N‐mWO3 sensor can recognize ppm‐level concentration of ammonia, which lays a solid foundation for its application in various fields.
Constructing Pd and Cu Crowding Single Atoms by Protein Confinement to Promote Sonogashira Reaction
Authors: Zhao Qinying , Zhao Xudong , Liu Zhiyi , Ge Yi , Ruan Jiaxiong , Cai Hongyi , Zhang Shasha , Ye Chenliang , Xiong Yu , Chen Wei , Meng Ge , Liu Zhiliang , Zhang Jian 
Published: July 2024

AbstractFor multicenter‐catalyzed reactions, it is important to accurately construct heterogeneous catalysts containing multiple active centers with high activity and low cost, which is more challenging compared to homogeneous catalysts because of the low activity and spatial confinement of active centers in the loaded state. Herein, a convenient protein confinement strategy is reported to locate Pd and Cu single atoms in crowding state on carbon coated alumina for promoting Sonogashira reaction, the most powerful method for constructing the acetylenic moiety in molecules. The single‐atomic Pd and Cu centers take advantage in not only the maximized atomic utilization for low cost, but also the much‐enhanced performance by facilitating the activation of aryl halides and alkynes. Their locally crowded dispersion brings them closer to each other, which facilitates the transmetallation process of acetylide intermediates between them. Thus, the Sonogashira reaction is drove smoothly by the obtained catalyst with a turnover frequency value of 313 h−1, much more efficiently than that by commercial Pd/C and CuI catalyst, conventional Pd and Cu nanocatalysts, and mixed Pd and Cu single‐atom catalyst. The obtained catalyst also exhibits the outstanding durability in the recycling test.
Elucidating the Mechanism of Iron‐Catalyzed Graphitization: The First Observation of Homogeneous Solid‐State Catalysis
Authors: Hunter Robert D. , Takeguchi Masaki , Hashimoto Ayako , Ridings Kannan M. , Hendy Shaun C. , Zakharov Dmitri , Warnken Nils , Isaacs Jack , Fernandez‐Muñoz Sol , Ramirez‐Rico Joaquín , Schnepp Zoe 
Published: July 2024

AbstractCarbon is a critical material for existing and emerging energy applications and there is considerable global effort in generating sustainable carbons. A particularly promising area is iron‐catalyzed graphitization, which is the conversion of organic matter to graphitic carbon nanostructures by an iron catalyst. In this paper, it is reported that iron‐catalyzed graphitization occurs via a new type of mechanism that is called homogeneous solid‐state catalysis. Dark field in situ transmission electron microscopy is used to demonstrate that crystalline iron nanoparticles “burrow” through amorphous carbon to generate multiwalled graphitic nanotubes. The process is remarkably fast, particularly given the solid phase of the catalyst, and in situ synchrotron X‐ray diffraction is used to demonstrate that graphitization is complete within a few minutes.
Optimizing Double‐Fibril Network Morphology via Solid Additive Strategy Enables Binary All‐Polymer Solar Cells with 19.50% Efficiency
Authors: Song Jiali , Li Chao , Ma Haisheng , Han Bingyu , Wang Qianqian , Wang Xunchang , Wei Donghui , Bu Laju , Yang Renqiang , Yan He , Sun Yanming 
Published: July 2024

AbstractDouble‐fibril network morphology (DFNM), in which the donor and the acceptor can self‐assemble into a double‐fibril structure, is beneficial for exciton dissociation and charge transport in organic solar cells. Herein, it is demonstrated that such DFNM can be constructed and optimized in all‐polymer solar cells (all‐PSCs) with the assistance of 2‐alkoxynaphthalene volatile solid additives. It is revealed that the incorporation of 2‐alkoxynaphthalene can induce a stepwise regulation in the aggregation of donor and acceptor molecules during film casting and thermal annealing processes. Through altering the alkoxy of 2‐alkoxynaphthalene solid additives, both the intermolecular interactions and molecular miscibility with the host materials can be precisely tuned, which allows for the optimization of the molecular aggregation process and facilitation of molecular self‐assembly, and thus leading to reinforced molecular packing and optimized DFNM. As a result, an unprecedented efficiency of 19.50% (certified as 19.1%) is obtained for 2‐ethoxynaphthalene‐processed PM6:PY‐DT‐X all‐PSCs with excellent photostability (T80 = 1750 h). This work reveals that the optimization of DFNM via solid additive strategy is a promising avenue to boosting the performance of all‐PSCs.
Flash Joule Heating: A Promising Method for Preparing Heterostructure Catalysts to Inhibit Polysulfide Shuttling in Li–S Batteries
Authors: Dong Huiyi , Wang Lu , Cheng Yi , Sun Huiyue , You Tianqi , Qie Jingjing , Li Yifan , Hua Wuxing , Chen Ke 
Published: July 2024

AbstractThe “shuttle effect” issue severely hinders the practical application of lithium–sulfur (Li–S) batteries, which is primarily caused by the significant accumulation of lithium polysulfides in the electrolyte. Designing effective catalysts is highly desired for enhancing polysulfide conversion to address the above issue. Here, the one‐step flash‐Joule‐heating route is employed to synthesize a W‐W2C heterostructure on the graphene substrate (W‐W2C/G) as a catalytic interlayer for this purpose. Theoretical calculations reveal that the work function difference between W (5.08 eV) and W2C (6.31 eV) induces an internal electric field at the heterostructure interface, accelerating the movement of electrons and ions, thus promoting the sulfur reduction reaction (SRR) process. The high catalytic activity is also confirmed by the reduced activation energy and suppressed polysulfide shuttling by in situ Raman analyses. With the W‐W2C/G interlayer, the Li–S batteries exhibit an outstanding rate performance (665 mAh g−1 at 5.0 C) and cycle steadily with a low decay rate of 0.06% over 1000 cycles at a high rate of 3.0 C. Moreover, a high areal capacity of 10.9 mAh cm−2 (1381.4 mAh g−1) is obtained with a high area sulfur loading of 7.9 mg cm−2 but a low electrolyte/sulfur ratio of 9.0 µL mg−1.
High rhizospheric ammonium levels in Sorghum halepense (johnsongrass) suggests nitrification inhibition potential
Authors: Ghosh Eeshita , Rajan Nithya , Phuyal Dinesh , Subramanian Nithya , Bagavathiannan Muthukumar 
Published: July 2024

AbstractPlants, such as sorghum (Sorghum bicolor), have been shown to secrete root exudates involved in biological nitrification inhibition (BNI), an ability to suppress the conversion of ammonium to nitrate and thereby minimize its loss. Johnsongrass (Sorghum halepense), a weedy relative of cultivated sorghum, may also possess BNI potential, but little is known in this regard. Here, we conducted a field survey at seven different sites in Southeast Texas to determine this evolutionary trait of johnsongrass in different soil environments. It was found that johnsongrass rhizosphere retains high levels (>60%) of ammonium within the total available N (ammonium + nitrate). Furthermore, the degree of ammonium retention by johnsongrass rhizosphere was significantly greater (up to 40%) in the roadside habitat compared to cultivated fields. The high ammonium retention potential by johnsongrass may explain, in part, their persistence and dominance, especially in marginal environments.Core Ideas
Nitrogen is a limiting nutrient for plant growth, and nitrification causes loss of nitrogen.
Ammonium retention was higher in roadside johnsongrass biotypes compared to that of cropland biotypes.
The high rhizoshpheric ammonium retention by johnsongrass may explain, at least in part, its invasiveness.
This trait could be further investigated and integrated into modern sorghum cultivars.
A novel metal‐organic framework encapsulated iridium oxide nanozyme enhanced antisense oligonucleotide combo for osteoarthritis synergistic therapy
Authors: Wu Shuqi , Nan Fang , Zhang Kewen , Hao Wan , Shi Di , Li Yang , Deng Wei , Jarhen Nur , Li Kaixuan , Xiao Yunyun , Li Jun , Lin Xiao 
Published: July 2024

AbstractOsteoarthritis (OA) is associated with metabolic imbalance of articular cartilage and an increase of intracellular reactive oxygen species (ROS). Synergistic therapy based on the codelivery of ROS scavengers and antisense oligonucleotides (ASO) into chondrocytes has the potential to effectively treat OA. Here, we developed a novel biocompatible metal‐organic framework (MOF)‐encapsulated nanozyme/ASO delivery platform (miR/IrO2@ZIF‐8) for OA treatment. IrO2 nanoparticles with the catalytic activities of superoxide dismutase/catalase were synthesized using a hydrothermal method, resulting in excellent ROS scavenging performance. IrO2 was further loaded into zeolitic imidazolate framework‐8 (ZIF‐8) to maintain its catalytic efficacy and regulate its size, surface charge, and biocompatibility to enhance the therapeutic effect of the platform. As an effective ASO delivery carrier, the synthesized IrO2@ZIF‐8 exhibited high antagomiR‐181a loading and lysosomal escape capacity, enabling it to rebalance cartilage metabolism. In vitro experiments showed that miR/IrO2@ZIF‐8 could restore ROS levels, mitochondrial membrane potential, and lipid peroxidation in chondrocytes. At the same time, the expression levels of proinflammatory markers (IL‐1β, IL‐6, and COX‐2) as well as the extracellular matrix degrading enzymes (ADAMTS‐5 and MMP13) were downregulated, indicating effective antioxidant, anti‐inflammatory, and anticartilage degradation effects. Notably, miR/IrO2@ZIF‐8 was able to deliver IrO2 nanoparticles and antagomiR‐181a to the cartilage tissue at a depth of up to 1.5 mm, thus solving the problems of poor permeability and difficult retention of drugs in cartilage tissue. This further improves the synergistic therapeutic effect on OA by inhibiting cartilage degradation. The combination of MOF‐encapsulated IrO2 nanozymes with antagomiR‐181a has an excellent therapeutic effect on OA, offering a promising translational medicine paradigm.
Simulation of non‐Newtonian biopolymer extrusion and fall in the centrifugal microencapsulation process
Authors: Badalan Matei , Ghigliotti Giovanni , Roux Denis , Maîtrejean Guillaume , Achard Jean‐Luc , Bottausci Frédéric , Balarac Guillaume 
Published: July 2024

AbstractWe present high‐fidelity numerical simulations of the centrifugal microencapsulation process, that is of interest for biomedical applications as cell therapy. We provide first a comprehensive rheological characterization of high‐molecular‐weight calcium alginate, a commonly used material in microencapsulation. Building upon this, we employ a fluid model that accurately replicates the relevant non‐Newtonian properties of the fluid. This model is applied to numerical simulations of the first three stages of the centrifugal microencapsulation process: capillary flow, ejection from the capillary, and fall through the air. The results are successfully compared with experiments. Furthermore, this model, which can be adapted to various centrifugal microencapsulation devices, effectively elucidates the physical factors contributing to different capsule shapes that can be achieved at the end of the process. This breakthrough opens the door to precise control of capsule shapes and production rates.
Polygene by environment interactions predicting depressive outcomes
Authors: Grillo Alessandra R. 
Published: July 2024

AbstractDepression is a major public health problem with a continued need to uncover its etiology. Current models of depression contend that gene‐by‐environment (G × E) interactions influence depression risk, and further, that depression is polygenic. Thus, recent models have emphasized two polygenic approaches: a hypothesis‐driven multilocus genetic profile score (MGPS; “MGPS × E”) and a polygenic risk score (PRS; “PRS × E”) derived from genome‐wide association studies (GWAS). This review for the first time synthesizes current knowledge on polygene by environment “P × E” interaction research predicting primarily depression‐related outcomes, and in brief, neurobiological outcomes. The “environment” of focus in this project is stressful life events. It further discusses findings in the context of differential susceptibility and diathesis‐stress theories—two major theories guiding G × E work. This synthesis indicates that, within the MGPS literature, polygenic scores based on the serotonin system, the HPA axis, or across multiple systems, interact with environmental stress exposure to predict outcomes at multiple levels of analyses and most consistently align with differential susceptibility theory. Depressive outcomes are the most studied, but neuroendocrine, and neuroimaging findings are observed as well. By contrast, vast methodological differences between GWAS‐based PRS studies contribute to mixed findings that yield inconclusive results.
Independent inheritance of cognition and bipolar disorder in a family sample
Authors: D'Amico Alexander , Sung Heejong , Arbona‐Lampaya Alejandro , Freifeld Ally , Hosey Katie , Garcia Joshua , Lacbawan Ley , Besançon Emily , Kassem Layla , Akula Nirmala , Knowles Emma E. M. , Dickinson Dwight , McMahon Francis J. 
Published: July 2024

AbstractCognitive deficits in people with bipolar disorder (BD) may be the result of the illness or its treatment, but they could also reflect genetic risk factors shared between BD and cognition. We investigated this question using empirical genetic relationships within a sample of patients with BD and their unaffected relatives. Participants with bipolar I, II, or schizoaffective disorder (“narrow” BD, n = 69), related mood disorders (“broad” BD, n = 135), and their clinically unaffected relatives (n = 227) completed five cognitive tests. General cognitive function (g) was quantified via principal components analysis (PCA). Heritability and genetic correlations were estimated with SOLAR‐Eclipse. Participants with “narrow” or “broad” diagnoses showed deficits in g, although affect recognition was unimpaired. Cognitive performance was significantly heritable (h2 = 0.322 for g, p < 0.005). Coheritability between psychopathology and g was small (0.0184 for narrow and 0.0327 for broad) and healthy relatives of those with BD were cognitively unimpaired. In this family sample, cognitive deficits were present in participants with BD but were not explained by substantial overlaps in genetic determinants of mood and cognition. These findings support the view that cognitive deficits in BD are largely the result of the illness or its treatment.
Diet and seed dispersal of bearded capuchin monkeys (Sapajus libidinosus) in Brasilia National Park
Authors: de Albuquerque Teixeira Samara , Souza‐Alves João Pedro , Bezerra de Melo Risolândia , Henriques Tavares Maria Clotilde , Haugaasen Torbjørn 
Published: July 2024

AbstractThe dietary ecology of a species can provide information on habitat requirements, food resources, and trophic interactions, important to guide conservation efforts of wildlife populations in endangered habitats. In this study, we investigated the dietary ecology of bearded capuchin monkeys (Sapajus libidinosus) in Brasilia National Park, in the endangered Cerrado biome of central Brazil. To obtain diet composition and evaluate the role of these primates as seed dispersers of local tree species, fecal sample collections and feeding observations were performed for a 7‐month period. To determine whether seeds germinated better after passing through a primate gut, we conducted germination trials with (i) pulped seeds from trees, (ii) depulped seeds from trees, (iii) seeds from feces planted with feces, and (iv) seeds from feces planted without feces. During experimental procedures, 7308 seeds from 8 families and 10 species were planted. We found that S. libidinosus spent more time feeding on fruits than on any other food item and the diet consisted of 33 plant species from 21 families. However, 20% of their diet consisted of anthropic food. Most seeds planted with feces germinated faster compared to seeds in other experimental treatments, suggesting that passing through the gut and being deposited with fecal material is advantageous. The bearded capuchins also defecated many medium‐ (5 species) and large‐sized (2 species) seeds that may be inaccessible to smaller arboreal frugivores. The results obtained emphasize the important role of bearded capuchins as seed dispersers for the maintenance and conservation of the endangered Cerrado biome.
A methodological pipeline for the preclinical evaluation of novel topical agents for the treatment of CRS
Authors: Hale Samuel J. M. , Lux Christian A. , Willoughby James E. , Koefoed Arne , Broderick David , Biswas Kristi , Kim Raymond , Mackenzie Brett Wagner , Douglas Richard G. 
Published: July 2024

Key points
Novel topical therapeutics require extensive pre‐clinical testing to assess efficacy and safety.
Antibiofilm or immunosuppressant agents can utilize ex vivo models to measure ciliotoxicity.
Agents that are found to be effective and non‐toxic ex vivo warrant further investigation in vivo.
Shear‐Strained Pd Single‐Atom Electrocatalysts for Nitrate Reduction to Ammonia
Authors: Liu Yunliang , Zhuang Zechao , Liu Yixian , Liu Naiyun , Li Yaxi , Cheng Yuanyuan , Yu Jingwen , Yu Ruohan , Wang Dingsheng , Li Haitao 
Published: July 2024

AbstractElectrochemical nitrate reduction method (NitRR) is a low‐carbon, environmentally friendly, and efficient method for synthesizing ammonia, which has received widespread attention in recent years. Copper‐based catalysts have a leading edge in nitrate reduction due to their good adsorption of *NO3. However, the formation of active hydrogen (*H) on Cu surfaces is difficult and insufficient, resulting in a large amount of the by‐product NO2−. In this work, Pd single atoms suspended on the interlayer unsaturated bonds of CuO atoms formed due to dislocations (Pd−CuO) were prepared by low temperature treatment, and the Pd single atoms located on the dislocations were subjected to shear stress and the dynamic effect of support formation to promote the conversion of nitrate into ammonia. The catalysis had an ammonia yield of 4.2 mol. gcat−1. h−1, and a Faraday efficiency of 90 % for ammonia production at −0.5 V vs. RHE. Electrochemical in situ characterization and theoretical calculations indicate that the dynamic effects of Pd single atoms and carriers under shear stress obviously promote the production of active hydrogen, reduce the reaction energy barrier of the decision‐making step for nitrate conversion to ammonia, further promote ammonia generation.