bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal or Mechanical Stimuli‐Induced Photoluminescence Color Change of a Molecular Assembly Composed of an Amphiphilic Anthracene Derivative in Water
Authors: Sagara Yoshimitsu , Komatsu Toru , Terai Takuya , Ueno Tasuku , Hanaoka Kenjiro , Kato Takashi , Nagano Tetsuo 
Published: July 2014

AbstractMolecular assemblies that change photoluminescence color in response to thermal or mechanical stimulation without dissociation into the monomeric states in water are described herein. A dumbbell‐shaped amphiphilic compound forms micellar molecular assemblies in water and exhibits yellow photoluminescence derived from excimer formation of the luminescent core, which contains a 2,6‐diethynylanthracene moiety. Annealing of the aqueous solution induces a photoluminescence color change from yellow to green (λem, max=558→525 nm). The same photoluminescence color change is also achieved by rubbing the yellow‐photoluminescence‐emitting molecular assemblies adsorbed on glass substrates with cotton wool in water. The observed green photoluminescence is ascribed to micelles that are distinct from the yellow‐photoluminescence‐emitting micelles, on the basis of transmission electron microscopy observations, atomic force microscopy observations, and dynamic light scattering measurements. We examined the relationship between the structure of the molecular assemblies and the photophysical properties of the anthracene derivative in water before and after thermal or mechanical stimulation and concluded that thermal or mechanical stimuli‐induced slight changes of the molecular‐assembled structures in the micelles result in the change in the photoluminescence color from yellow to green in water.
Peptides Come Round: Using SICLOPPS Libraries for Early Stage Drug Discovery
Authors: Lennard Katherine R. , Tavassoli Ali 
Published: July 2014

AbstractCyclic peptides are an emerging class of molecular therapeutics that are increasingly viewed as ideal backbones for modulation of protein–protein interactions. A split‐intein based method, termed SICLOPPS, enables the rapid generation of genetically encoded cyclic peptide libraries of around a hundred million members. Here we review recent approaches using SICLOPPS for the discovery of bioactive compounds.
Synthesis of Prenyl‐ and Geranyl‐Substituted Carbazole Alkaloids by DIBAL‐H Promoted Reductive Pyran Ring Opening of Dialkylpyrano[3,2‐a]carbazoles
Authors: Hesse Ronny , Kataeva Olga , Schmidt Arndt W. , Knölker Hans‐Joachim 
Published: July 2014

AbstractThe DIBAL‐H promoted reductive pyran ring opening of dialkylpyrano[3,2‐a]carbazoles provides a direct access to a broad range of prenyl‐ and geranyl‐substituted carbazoles. Formation of a pyran ring followed by reductive ring opening represents a new method for the introduction of prenyl and geranyl groups. In the course of the present work, we achieved the first total syntheses of the following eight carbazole alkaloids: clauraila‐E, 7‐hydroxyheptaphylline, 7‐methoxyheptaphylline, mukoenine‐B (clausenatine‐A), mukoenine‐A (girinimbilol), mahanimbinol (mahanimbilol), euchrestine‐A, and isomurrayafoline‐B.
Ionische Flüssigkeiten im Schulunterricht
Authors: Pellowska Maren , Handel Robyn , Bader Hans Joachim , Flint Alfred 
Published: July 2014

AbstractIonische Verbindungen, die unter 100 °C schmelzen, werden Ionische Flüssigkeiten genannt. Diesen Verbindungen kommt seit einigen Jahren wegen ihrer Eigenschaften als Lösungsmittel oder Reaktionsmedien eine stetig steigende Bedeutung zu. In diesem Beitrag werden Aufbau und Eigenschaften Ionischer Flüssigkeiten dargestellt sowie Vorschläge für einführende Experimente gegeben.
Substance use disorder and its effects on outcomes in men with advanced‐stage prostate cancer
Authors: Chhatre Sumedha , Metzger David S. , Malkowicz S. Bruce , Woody George , Jayadevappa Ravishankar 
Published: July 2014

BACKGROUNDSubstance use disorder in patients with cancer has implications for outcomes. The objective of this study was to analyze the effects of the type and timing of substance use on outcomes in elderly Medicare recipients with advanced prostate cancer.METHODSThis was an observational cohort study using Surveillance, Epidemiology, and End Results (SEER)‐Medicare linked data from 2000 to 2009. Among men who were diagnosed with advanced prostate cancer between 2001 and 2004, we identified those who had a claim for substance use disorder in the year before cancer diagnosis, 1 year after cancer diagnosis, and an additional 4 years after diagnosis. The outcomes investigated were use of health services, costs, and mortality.RESULTSThe prevalence of substance use disorder was 10.6%. The category drug psychoses and related had greater odds of inpatient hospitalizations (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.9‐2.8), outpatient hospital visits (OR, 2.6; 95% CI, 1.9‐3.6), and emergency room visits (OR, 1.7; 95% CI, 1.2‐2.4). Substance use disorder in the follow‐up phase was associated with greater odds of inpatient hospitalizations (OR, 2.0; 95% CI, 1.8‐2.2), outpatient hospital visits (OR, 2.0; 95% CI, 1.7‐2.4), and emergency room visits (OR, 1.7; 95% CI, 1.5‐2.1). Compared with men who did not have substance use disorder, those in the category drug psychoses and related had 70% higher costs, and those who had substance use disorder during the follow‐up phase had 60% higher costs. The hazard of all‐cause mortality was highest for patients in the drug psychoses and related category (hazard ratio, 1.3; 95% CI, 1.1‐1.7) and the substance use disorder in treatment phase category (hazard ratio, 1.5; 95% CI, 1.3‐1.7).CONCLUSIONSThe intersection of advanced prostate cancer and substance use disorder may adversely affect outcomes. Incorporating substance use screening and treatments into prostate cancer care guidelines and coordination of care is desirable. Cancer 2014;120:3338–3345. © 2014 American Cancer Society.
Cytology and human papillomavirus testing on cytobrushing samples from patients with head and neck squamous cell carcinoma
Authors: Donà Maria Gabriella , Giuliani Massimo , Vocaturo Amina , Spriano Giuseppe , Pichi Barbara , Rollo Francesca , Ronchetti Livia , Covello Renato , Pescarmona Edoardo , Benevolo Maria 
Published: July 2014

BACKGROUNDThe increasing incidence of human papillomavirus (HPV)‐related head and neck squamous cell carcinoma (HNSCC) highlights the need for simple and effective tools to evaluate head and neck lesions and their HPV status. The main objective of the current study was to investigate the association between abnormal cytology and HPV infection, assessed on cytobrushing samples, and histologically confirmed HNSCC. Second, the authors attempted to investigate whether HPV status on cytobrushing samples reflected that of the tumoral tissue.METHODSA total of 164 samples from HNSCC, nonmalignant lesions, or healthy mucosae of the oral cavity and oropharynx were collected by cytobrushing in PreservCyt solution and evaluated by liquid‐based cytology and Linear Array HPV genotyping test. All the findings from the cytologic samples were compared with those from the corresponding histologic samples.RESULTSPatients with abnormal cytology had a significantly higher risk of having an HNSCC (odds ratio [OR], 9.18; 95% confidence inteval [95% CI], 3.27‐26.49). The association was stronger for oral cancer (OR, 10.86; 95% CI, 2.51‐51.06) than oropharyngeal cancer (OR, 8.45; 95% CI, 1.62‐49.82). HPV positivity in the oropharyngeal cytobrushing was associated with a nearly 5‐fold higher risk of having abnormal cytology (OR, 4.57; 95% CI, 1.57‐13.57) as well as histologically proven oropharyngeal cancer (OR, 5.09; 95% CI, 1.09‐31.61). Comparing the HPV status on cytologic and corresponding histologic samples from patients with HNSCC, we found that 90.4% of the cases were concordant (kappa, 0.796).CONCLUSIONSAbnormal brushing cytology is strongly associated with a diagnosis of HNSCC, whereas HPV positivity on cytobrushing samples is only associated with oropharyngeal cancer. HPV testing on cytobrushing samples represents a valid option for the assessment of HPV infection in patients with oropharyngeal cancer. Cancer 2014;120:3477–3484. © 2014 American Cancer Society.
A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens
Authors: Liu Yi‐Zhen , Jiang Yan‐Yi , Wang Bo‐Shi , Hao Jia‐Jie , Shang Li , Zhang Tong‐Tong , Cao Jian , Xu Xin , Zhan Qi‐Min , Wang Ming‐Rong 
Published: July 2014

BACKGROUNDTo date, no robust biomarkers have been available in clinical practice that can provide an early diagnostic evaluation of lung cancer. The objective of this study was to identify potential biomarkers for the early detection of lung cancer using bronchial brushing specimens.METHODSImmunocytochemistry was used to investigate the expression of 35 proteins in 880 bronchial brushing specimens from both outpatients and inpatients who had either lung cancer or benign lung lesions. An optimal panel was identified that had high sensitivity and considerable specificity for detecting lung cancer. Associations between protein expression and clinicopathologic parameters were assessed.RESULTSTumor protein 53 (TP53), TP63, Ki67, epidermal growth factor receptor (EGFR), minichromosome maintenance complex component 6 (MCM6), MCM7, uncharacterized proteins KIAA1522 and KIAA0317, and ubiquitin‐protein ligase UHR1 (ICBP90) frequently presented high expression in bronchial brushing specimens from patients who had lung cancer compared with patients who had benign lung lesions. A 6‐protein panel consisting of TP53, Ki67, MCM6, MCM7, KIAA1522, and KIAA0317 was identified as the best combination, with sensitivity of 81.1% (309 of 381 specimens) for detecting nonsmall cell lung cancer (NSCLC) and 86.8% (145 of 167 specimens) for detecting small cell lung cancer (SCLC) (specificity, 83.3%; 65 of 78 specimens). The combination of cytology and the protein panel significantly improved the sensitivity of bronchial brushing examination for detecting lung cancer (P<.00001), which increased from 49.1% to 81% in early stage NSCLC (stage I and II). In combined analyses, the protein panel was positively associated with patient sex (P=.00033), tumor type (P<.00001), tumor location (P<.00001), and lymph node metastasis (P=.028).CONCLUSIONSThe 6‐protein panel is a potential biomarker for the early detection of lung cancer in bronchial brushings. Cancer (Cancer Cytopathol) 2014;122:833–841. © 2014 American Cancer Society.
Early, Middle, or Late Administration of Zoledronate Alleviates Spontaneous Nociceptive Behavior and Restores Functional Outcomes in a Mouse Model of CFA‐Induced Arthritis
Authors: Morado‐Urbina Carlos Eduardo , Alvarado‐Vázquez Perla Abigail , Montiel‐Ruiz Rosa Mariana , Acosta‐González Rosa Issel , Castañeda‐Corral Gabriela , Jiménez‐Andrade Juan Miguel 
Published: July 2014

Abstract

Preclinical Research

This study was performed to evaluate whether early, middle, or late treatment of zoledronate, an approved bisphosphonate that blocks bone resorption, can reduce nociceptive behaviors in a mouse arthritis model. Arthritis was produced by repeated intra‐articular knee injections of complete Freund's adjuvant (CFA). A dose‐response curve with zoledronate (3, 30, 100, and 300 μg/kg, i.p., day 4 to day 25, twice weekly for 3 weeks) was performed, and the most effective dose of zoledronate (100 μg/kg, i.p.) was initially administered at different times of disease progression: day 4 (early), day 15 (middle), or day 21 (late) and continued until day 25 after the first CFA injection. Flinching of the injected extremity (spontaneous nociceptive behavior), vertical rearings and horizontal activity (functional outcomes), and knee edema were assessed. Zoledronate improved both functional outcomes and reduced flinching behavior. At day 25, the effect of zoledronate on flinching behavior and vertical rearings was greater in magnitude when it was given early or middle rather than late in the treatment regimen. Chronic zoledronate did not reduce knee edema in CFA‐injected mice nor functional outcomes in naïve mice by itself. These results suggest that zoledronate may have a positive effect on arthritis‐induced nociception and functional disabilities.
Mother recognition and preference after neonatal amygdala lesions in rhesus macaques (Macaca mulatta) raised in a semi‐naturalistic environment
Authors: Goursaud Anne‐Pierre S. , Wallen Kim , Bachevalier Jocelyne 
Published: July 2014

ABSTRACTAttachment to the caregiver, typically the biological mother, is crucial to young mammals' socio‐emotional development. Although studies in nonprimate species suggest that the amygdala regulates social preference and attachment development, its role in primate filial attachment development has been little investigated and has produced mixed results. This study assessed the effects of neonatal amygdala‐ (Neo‐A, N = 16) and sham‐ (Neo‐C, N = 12) lesions on mother recognition and discrimination in macaques raised in species‐typical social groups. Neonatal amygdalectomy did not affect social discriminative abilities and mother preference at 3 and 6 months of age, strongly suggesting that the amygdala is not involved in the cognitive processes underlying the development of filial attachment at least when the amygdala damage occurred after the third to fourth weeks of age. Nevertheless, as compared to sham‐operated controls, amygdalectomized infants initiated physical contact with their mothers less frequently. The findings are discussed in relation to the known contribution of the amygdala to filial attachment in both rodents and humans. © 2014 Wiley Periodicals, Inc. Dev Psychobiol 56: 1723–1734, 2014.
Perceptual narrowing: Retrospect and prospect
Authors: Flom Ross 
Published: July 2014

ABSTRACTResearch is reviewed demonstrating perceptual narrowing across a variety of domains. Research is also reviewed showing that the temporal window of perceptual narrowing can be extended and, in some cases, perceptual narrowing can be reversed. Research is also reviewed highlighting the neurophysiological correlates of perceptual narrowing as well as some of the individual neurophysiological differences associated with perceptual narrowing. Various methodological issues associated with perceptual narrowing are also discussed. The broader purpose of this paper, however, is to argue that the term perceptual narrowing fails to capture the dynamic nature of this perceptual process. Finally, it is argued that just as other concepts associated with experience and development are refined and modified as new evidence emerges, likewise we need to evaluate and refine how we conceptualize perceptual narrowing. © 2014Wiley Periodicals, Inc. Dev Psychobiol 56: 1442–1453, 2014.
Diabetes Metabolism: Research and Reviews – Chinese Diabetes Society special issue: a small but encouraging step toward the successful control of diabetes in China
Authors: Weng Jianping , Pozzilli Paolo 
Published: July 2014

AbstractIt is now recognised that nearly one third of all people with diabetes worldwide are Chinese and that this disease is the third leading cause of death in China. In this special issue of the journal we publish articles covering a number of clinical and experimental studies of diabetes as well as metabolic diseases in China with the aim of helping the readers to better understand the overall picture of this disease in China.
Linear Analysis of the Corticothalamic Model with Time Delay
Authors: Yamaguchi Ikuhiro , Ogawa Yutaro , Nakao Hiroya , Jimbo Yasuhiko , Kotani Kiyoshi 
Published: July 2014

SummaryThe corticothalamic Compact Model with time delay proposed by Kim and Robinson is analyzed focusing on the resting EEG, which can be described by the linear version of the model with white‐noise input, under the assumption of spatial homogeneity and temporal steadiness. After discussing the availability and restriction of the model by comparing to the original Pre‐Compact Model, a data analysis method for the resting EEG using the model is presented. The experimental results analyzed by the method suggest that the eye‐closed state compared to the eye‐open state would be characterized by enhanced corticothalamic feedback and depressed cortical excitation. The validity of the Reduced Equations derived in our previous paper is also investigated for the resting EEG, concluding that the Reduced Equations would be available with some restriction for the resting EEG, although the center manifold theory on which the Reduced Equations are based is justified at the edge of linear stability in principle.
Portfolio Strategy Optimizing Model for Risk Management Utilizing Evolutionary Computation
Authors: Matsumura Koki , Kakinoki Hidefumi 
Published: July 2014

SUMMARYThis paper proposes a new optimizing system for stock portfolios that uses evolutionary computation techniques to derive a highly suitable combination and investment ratio of brands as well as an appropriate trading‐strategy tree. Accurately predicting price trends in the stock market is a difficult task to achieve with the result that investors often suffer great losses. Because stock portfolios are thought to be a valid means of avoiding such risks in terms of financial engineering, they have the effect of reducing risk by diversifying investment into several different brands. Based on this, it was attempted to determine an optimal combination of brands that constitute a portfolio and to derive the investment ratio using a multiobjective genetic algorithm, and also to optimize a trading strategy tree using genetic programming. When a performance evaluation was carried out, the system was found to generally obtain the operative results by making it possible to obtain stable profits using a combination of low risk brands. The system was also able to realize low risk investments in all test periods.
Using Simulations to Evaluate Input‐Site and Tetanized‐Site Specificity of Tetanic Effect on Neuronal Networks
Authors: Yada Yuichiro , Haga Tatsuya , Miyazako Hiroki , Takayama Yuzo , Fukayama Osamu , Hoshino Takayuki , Mabuchi Kunihiko 
Published: July 2014

SUMMARYPlasticity of neuronal networks is widely investigated as the basis of learning and stimulus‐induced plasticity is one of the remarkable topics. For inducing plasticity and leading a network to a desired state, effective stimuli have to be applied to the network. However, the effect of stimuli on living neuronal networks is difficult to evaluate because of the unsteadiness of the network property. In this paper, we produce a simulated neuronal network and compare the effects of tetanic stimulus at various sites of networks in silico. Using simulation, the tetanic effects can be evaluated irrespective of network transition. We confirmed that the direction of the network plasticity is determined by the tetanized site in the network, and this can be observed only when the proper test‐stimulus site is selected. We conclude that this simulation‐based approach effectively evaluates the stimulus effect on neuronal networks.
The Effect of the Ratio of [M/(B+P)] on the Configuration of Anionic Groups: Synthesis of the Borate–Phosphate LiPb4(BO3)(PO4)2
Authors: Huang Shengshi , Yu Hongwei , Han Jian , Pan Shilie , Jing Qun , Wang Ying , Dong Lingyun , Wu Hongping , Yang Zhihua , Wang Xian 
Published: July 2014

AbstractCompounds containing both B–O and P–O groups are of wide interest and have been classified into borophosphates and borate–phosphates by R. Kniep et al. In addition to the B/P ratio, analysis results show that regulating the [M/(B+P)] ratio is also an effective strategy to synthesize new borate–phosphates. The first lithium lead borate–phosphate, LiPb4(BO3)(PO4)2, was synthesized by regulating this ratio. This compound crystallizes in the orthorhombic space group Pbca (No. 61). It possesses a 3D structure with a corrugated 2D layer of [B2Pb8O18]∞ that is further connected by a [LiP2O8]∞ chain; both BO3 and PO4 were isolated. First‐principle theoretical studies were performed to aid the understanding of the electronic structures and the linear optical properties. In addition, thermal analysis, IR spectroscopy, and UV/Vis/NIR diffuse reflectance spectroscopy were performed on the reported material.
Amphotericin B microparticles ‘AmbiShell’ from phospholipid and gelatin: Development and investigation by combined DLS and SANS resolves the core‐shell structure
Authors: Johnson Raphael , Nawroth Thomas , Khoshakhlagh Pooneh , Langguth Peter , Schmueser Lars , Hellmann Nadja , Decker Heinz , Szekely Noemi Kinga 
Published: July 2014

A novel homogenous core‐shell formulation ‘AmbiShell’ of the hydrophobic antifungal polyene drug Amphotericin B was prepared from the pure drug, lecithin, and gelatin. The established ‘Hydrophilic Solubilisation Technology’ (HST) was used for embedding the lipophilic drug with lecithin and gelatin, yielding core‐shell microparticles of 1 µm size. The particle size of the drug, the formulation, and the thickness of the coating were investigated by using dynamic light scattering (DLS), microscopy, UV–Visible spectroscopy and small angle neutron scattering (SANS). The drug in the formulation was not in the oligomer form but in a competent uptake form, as shown by the UV–Visible spectroscopy. The DLS and microscopy depicted the product to consist of spheres (∼1 µm). The SANS experiment using deuterium contrast matching of the drug cores revealed a thin layer span of 5.6 nm, which is similar, but slightly larger as compared to the biological lipid membranes. The finding offers opportunities for further improvements of the formulation, e.g., by surface modification.A soluble core‐shell formulation ‘AmbiShell’ of the hydrophobic antifungal polyene drug Amphotericin B was generated from drug, lecithin, and gelatin. The span of the lipid–gelatin shell was estimated by neutron scattering SANS with deuterium contrast matching of the drug core.
Selective, Nanomolar Electrochemical Determination of Environmental Contaminants Dihydroxybenzene Isomers Found in Water Bodies Using Nanocrystalline Zeolite Modified Carbon Paste Electrodes
Authors: Kaur Balwinder , Srivastava Rajendra 
Published: July 2014

AbstractNanocrystalline zeolites of different framework structures were prepared by the addition of suitable structure directing agents in the synthesis composition of conventional zeolites. Zeolite modified carbon paste electrodes were constructed for the simultaneous determination of dihydroxybenzene isomers. Nanocrystalline zeolite Beta modified carbon paste electrode exhibited the highest electrocatalytic activity. Under optimum conditions, wide linear range was obtained from 150 nM to 400 µM with lower detection limit of 100, 130, and 100 nM for hydroquinone, catechol, and resorcinol, respectively. The analytical performance of the proposed sensor was demonstrated in the simultaneous determination of dihydroxybenzene isomers in different environmental water samples.