bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐performance shape memory characteristics by integrating urea linkages into the polyurethane elastomer
Authors: Lee Jaeheon , Kim Jung Hyeun 
Published: August 2024

AbstractShape memory polymers have been widely researched to develop multifunctional materials that respond smartly to external stimulations and programmed signals. Among them, shape memory polyurethane (SMPU) is drawing great attention owing to its highly tunable properties and ease of integrating new functions. However, the effect of urea bonds on SMPU elastomers has rarely been investigated because of the extreme reactivity of amine crosslinkers. In this study, we used diethanolamine (DEOA), which contains a secondary amine, as the crosslinker for SMPU synthesis. Unlike other crosslinkers containing primary amines, they can form urea bonds in a more gentle manner. The urea bonds reinforce the intermolecular interactions between the hard segments with strong hydrogen bonding, thus increasing the phase separation and degree of crystallization. Consequently, the urea‐containing SMPU exhibits improved mechanical strength and shape memory abilities for both fixing and recovery. Moreover, the transcarbamoylation reaction, which enables the reconfiguration of the original shape, is observed. The introduction of the urea bonds into the SMPU elastomer can be beneficial in achieving flawless shape memory performances in various sensitive applications.
Binary nanoconjugation of zein–methylcellulose for improving curcumin properties: solubility, controlled release and anticancer activity
Authors: Abaza Sana F , Elbialy Nihal S , Mohamed Noha 
Published: August 2024

AbstractFor cancer treatment, a novel nanocarrier has been developed, utilizing natural compounds. Zein protein (Z) and methylcellulose (MC) polysaccharide were formulated as a nanocarrier for nutraceutical curcumin (Cur). The zein–methylcellulose nanoconjugate (ZMC) appeared spherical/monodispersed in transmission electron microscopy images. Hydrodynamic sizes were 164 ± 20.2 and 190 ± 28.2 nm for ZMC and ZMC@Cur, respectively. For both formulations, zeta potential, differential scanning calorimetry, Fourier transform infrared spectroscopy and X‐ray diffraction analyses were conducted. Curcumin encapsulation efficiency was 92%, and its release profile was pH responsive. Using MTT assay, ZMC@Cur demonstrated a significant cytotoxic effect against MCF‐7 and HepG2, surpassing the impact of curcumin. This underscores the pivotal role of ZMC@Cur in enhancing curcumin properties, thereby potentiating cancer cell death. Compared with free curcumin, ZMC@Cur markedly promoted DNA damage in cancer cells, owing to precise curcumin targeting into the nucleus. Accordingly, the proposed bionanocomposite stands as an efficient vehicle for curcumin, showcasing its crucial role in combating cancer via improving the pharmaceutical properties of curcumin. © 2024 Society of Chemical Industry.
Physical and chemical diagnostics of cold atmospheric pressure argon plasma jet
Authors: Lotfi Mohammad Reza , Tehrani Pouria Akbar , Khani Mohammadreza , Razaghiha Elahe , Ghasemi Erfan , Shokri Babak 
Published: August 2024

AbstractThis article presents an experimental investigation of an argon plasma jet. It examines a commercial argon plasma jet device's physical, chemical, and biological impacts, comparing findings against global standards. The study focuses on electrical features ensuring safety for patients and consumers, finding all leakage current values within established standards. Chemical analysis of emitted gases shows no detectable levels of harmful compounds near treated skin. Optical emission spectroscopy reveals bioactive compounds within the plasma jet. UV radiation emission remains within safety thresholds. Hyperspectral imaging shows temporary increases in skin characteristics posttreatment, reverting to baseline over time. Overall, the study demonstrates the safety and potential of the argon plasma jet in skin treatment.
Identification of MicroRNAs in children with increased asthma bronchodilator usage in genetics of asthma in Costa Rica Study
Authors: Wong Richard , Desai Brinda , Sharma Rinku , Srivastava Upasna , Kho Alvin T. , Weiss Scott T. , Celedón Juan C. , McGeachie Michael J. , Tantisira Kelan 
Published: August 2024

AbstractIntroductionUncontrolled or severe asthma results in symptomatic usage of short‐acting ß2‐agonist (SABA) usage. MicroRNAs (miRNAs) are posttranslational regulators that can influence asthma biology. This study aims to identify miRNAs that are associated with increased SABA usage.MethodsSmall RNA sequenced from blood serum of 1,132 children with asthma aged 6 to 14 years in the Genetics of Asthma in Costa Rica Study was used for this analysis. Logistic regression identified miRNAs in patients who required increased SABA usage. These miRNA were validated for association with SABA‐induced bronchodilator responsiveness (BDR). Gene target pathway analysis was performed on validated miRNAs.ResultsTwenty‐one miRNAs were significantly associated with increased SABA usage with OR ranging from 0.87 to 1.23. Two miRNAs, miR‐378a‐3p and miR‐144‐3p, had odds ratio 1.14 (1–1.29, p = .05) and 1.11 (1.01–1.22, p = .035), respectively, for increased SABA usage and were also significantly associated with bronchodilator response. Furthermore, a linear regression analysis involving these miRNA and bronchodilator response revealed that increased miR‐378a‐3p correlated with decreased BDR and increased expression of miR‐144‐3p correlated with improving pulmonary function with bronchodilators. In gene target Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the erythroblastosis viral oncogene signaling pathway had among one of the highest fold enrichment and p‐value.ConclusionIncreased expression of miR‐378a‐3p and miR‐144‐3p was seen in this patient population who required increased SABA usage. There were different bronchodilatory effects seen in these two miRNAs, suggesting different potential mechanisms underlying increased SABA usage.
Virus‐Induced Host Chemokine CCL2 in COVID‐19 Pathogenesis: Potential Prognostic Marker and Target of Anti‐Inflammatory Strategy
Authors: Ansari Abdul Wahid , Ahmad Fareed , Alam Majid Ali , Raheed Thesni , Zaqout Ahmed , Al‐Maslamani Muna , Ahmad Aamir , Buddenkotte Joerg , Al‐Khal Abdullatif , Steinhoff Martin 
Published: August 2024

ABSTRACTA wide variety of inflammatory mediators, mainly cytokines and chemokines, are induced during SARS CoV‐2 infection. Among these proinflammatory mediators, chemokines tend to play a pivotal role in virus‐mediated immunopathology. The C‐C chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein‐1 (MCP‐1) is a potent proinflammatory cytokine and strong chemoattractant of monocytes, macrophages and CD4+ T cells bearing C‐C chemokine receptor type‐2 (CCR2). Besides controlling immune cell trafficking, CCL2 is also involved in multiple pathophysiological processes including systemic hyperinflammation associated cytokine release syndrome (CRS), organ fibrosis and blood coagulation. These pathological features are commonly manifested in severe and fatal cases of COVID‐19. Given the crucial role of CCL2 in COVID‐19 pathogenesis, the CCL2:CCR2 axis may constitute a potential therapeutic target to control virus‐induced hyperinflammation and multi‐organ dysfunction. Herein we describe recent advances on elucidating the role of CCL2 in COVID‐19 pathogenesis, prognosis, and a potential target of anti‐inflammatory interventions.
An optimization‐based method for robust stabilization of linear delay systems
Authors: Hu Renhong , Mei Jie , Ma Guangfu 
Published: August 2024

AbstractThis paper investigates the robust stabilization problem of linear delay systems with parametric uncertainty. First, by means of the argument principle, a delay‐dependent sufficient condition is derived for designing a feedback controller, with which the closed‐loop system can achieve robust stability. Then, based on the fundamental matrix of the linear delay systems, a constrained optimization problem is formulated for solving the feedback gain matrices. The effectiveness of the proposed method is verified by some simulation results.
Comparing Antibiotic Prescribing Patterns for Hidradenitis Suppurativa between Dermatology and Non-Dermatology Ambulatory Providers
Authors: Tolson Hannah , Kikuchi Robin , Yamamoto Rebecca K. , Sadrolashrafi Kaviyon , Guo Lily , Hao Audrey , Bilimoria Sara , Yee Danielle , Armstrong April W. 
Published: August 2024

Abstract

Background
Oral antibiotics are a mainstay of treatment for hidradenitis suppurativa (HS) primarily due to their anti-inflammatory and anti-microbial properties. Because antibiotics are frequently prescribed to treat HS, concerns exist regarding antibiotic stewardship. There is a paucity of literature comparing how antibiotic prescribing patterns for HS differ between dermatology and non-dermatology clinicians in the ambulatory setting.

Objective
This study aims to compare the antibiotic prescribing patterns of dermatology versus non-dermatology clinicians treating HS in the ambulatory setting.

Methods
We utilised the National Ambulatory Medical Care Survey (NAMCS) to identify visits for HS patients from 2005 to 2016. We performed multivariate logistic regression analysis to compare the likelihood of prescribing (1) antibiotics and (2) tetracyclines between dermatology and non-dermatology clinicians in the ambulatory setting.

Results
We identified a total of 2 424 125 (weighted) HS visits. Approximately 28.0% of visits were conducted by dermatology clinicians, while 72.0% were conducted by non-dermatology clinicians. Antibiotics were prescribed in 51.9% of visits. Tetracyclines were the most commonly prescribed antibiotics among visits with dermatology clinicians (33.4%), while penicillins/cephalosporins were the most commonly prescribed antibiotic among visits with non-dermatology clinicians (14.9%). Multivariate logistic regression analysis demonstrated no difference in the overall likelihood of prescribing antibiotic therapy between dermatology and non-dermatology clinicians (p = 0.35). However, dermatology clinicians were significantly more likely to prescribe tetracyclines than non-dermatology clinicians (OR 5.48, 95% CI 1.19–25.26, p = 0.03).

Conclusion
In conclusion, dermatology clinicians were significantly more likely to prescribe tetracyclines than non-dermatology clinicians for HS patient visits.
Multilocular Subcutaneous Bacillary Angiomatosis as a Primary Manifestation of Aids
Authors: Duckwitz Theresa M. , Yazdi Amir S. , Kluwig David 
Published: August 2024

Abstract
A 34-year-old male patient presented with a clinical picture of multilocular subcutaneous skin nodules in addition to marked lymphadenopathy and general physical deterioration. A comprehensive diagnostic workup including serology, skin biopsy and imaging studies led to the initial diagnosis of human immunodeficiency virus (HIV) infection in AIDS stage with rare multilocular subcutaneous bacillary angiomatosis (BA) caused by Bartonella henselae. BA describes a process of neovascularisation of the skin or of internal organs (particularly the liver and spleen) and was first described in HIV-positive patients by Stoler et al. in 1983. Both cutaneous and systemic symptoms are variable. There is no standardized treatment. The patient was started on antibiotic therapy with doxycycline, which was subsequently augmented with rifampicin. As the patient's general condition deteriorated and lymphocytopenia aggravated, he was transferred to an internal medicine ward for further treatment and subsequently commenced on antiretroviral therapy. This case corroborates numerous aspects of the cases described in the literature yet differs from them in that subcutaneous lesions are uncommon, particularly when infected with Bartonella henselae, illustrating the clinical spectrum of BA. Furthermore, it emphasises the significance of prompt and thorough diagnosis encompassing HIV serology in instances of skin lesions, accompanied by systemic signs and evidence of immunosuppression.
An Integrated Micro‐Heating System for On‐Chip Isothermal Amplification of African Swine Fever Virus Genes
Authors: Sun Jiajia , Shi Zongqian , Tan Qiongxiang , Zhong Mingjie , Wang Nan , Xin Shumin , Liu Xiaofeng , Li Ruohan , Ma Yuxin , Wu Kai , Cui Yali , Hui Wenli 
Published: August 2024

AbstractThe loop‐mediated isothermal amplification (LAMP) is widely used in the laboratory to facilitate rapid DNA or RNA detection with a streamlined operational process, whose properties are greatly dependent on the uniformity and rise rate of temperature in the reaction chambers and the design of the primers. This paper introduces a planar micro‐heater equipped with an embedded micro‐temperature sensor to realize temperature tunability at a low energy cost. Moreover, a control system, based on the Wheatstone bridge and proportional, integral, and derivative (PID) control, is designed to measure and adjust the temperature of the micro‐heater. The maximum temperature rise rate of the designed micro‐heater is ≈8 °C s−1, and it only takes ≈60 s to reach the target temperature. Furthermore, a designed plasmid, containing the B646L gene of African Swine Fever Virus (ASFV), and a set of specific primers, are used to combine with the designed micro‐heating system to implement the LAMP reaction. Finally, the lateral flow assay is used to interpret the amplification results visually. This method can achieve highly sensitive and efficient detection of ASFV within 40 min. The sensitivity of this on‐chip gene detection method is 8.4 copies per reaction, holding great potential for applications in DNA and RNA amplification.
Efficient Recovery of Rare Earth Elements from Acidic Wastewater by a Green β‐CDs‐Functionalized Nanosponge
Authors: Xu Junxin , Wang Dandan , Yang Jianmei , He Junnan , Yang Tong , Zhao Xue , Liu Xiaoqing , Zhang Jin , Zhang Lei , Zhao Yan 
Published: August 2024

AbstractThe recovery of rare earth elements (REEs) from acidic wastewater is crucial to sustainable development, industrial processes, and human health. In this research, β‐cyclodextrin‐based nanosponges (β‐CD/PVA‐SA NSs) have been proposed as potential adsorbents for europium (Eu), dysprosium (Dy), and gadolinium (Gd) recovery. The nanosponges are synthesized by cross‐linking β‐cyclodextrin (β‐CD) functionalized polyvinyl alcohol (PVA) and sodium alginate (SA). Experimental results indicate that β‐CD/PVA‐SA NSs exhibit favorable selectivity for Eu, Dy, and Gd, with the maximum adsorption capacity of 222, 217, and 204 mg/g, respectively, in addition to stability and cyclicity. β‐CD/PVA‐SA NSs maintain selective adsorption effects towards RE ions that are present in acidic mine drainage (AMD), thereby highlighting their potential for practical applications. Furthermore, density functional theory (DFT) simulations have unveiled the fundamental interactions between the functional groups anchored in β‐CD/PVA‐SA NSs and the REEs, providing vital insights into their adsorption mechanism. Hence, the utilization of β‐CD/PVA‐SA NSs has the potential to advance initiatives in remediating acidic water pollution and facilitating the sustainable recycling of RE resources.
Exact interval estimation for three parameters subject to false positive misclassification
Authors: Lu Shuiyun , Wang Weizhen , Xie Tianfa 
Published: August 2024

SummaryBinary data subject to one type of misclassification exist in various fields. It is collected in a double‐sampling scheme that includes a gold standard test and a fallible test. The main parameter of interest for this type of data is the positive probability of the gold standard test. Existing intervals are unreliable because the given nominal level is not achieved. In this paper, we construct an exact interval by inverting the E+M score tests and improve it by the general ‐function method. We find that the total length of the improved interval is shorter than the exact intervals that are also the improved intervals when we apply the ‐function to several existing approximate intervals, including the score and Bayesian intervals. Therefore, it is recommended for practice. We are also interested in two other parameters: —the difference between the two positive rates for the fallible and gold standard tests—and —the false positive rate for the fallible test. To the best of our knowledge, the research on these two parameters is limited. For , we find that any interval for can be converted to an interval for . So, the interval converted from the aforementioned recommended interval for is recommended for inferring . For , the improved interval by the ‐function method over the E+M score interval is derived. We use an example to illustrate how the intervals are computed and provide a real data analysis.
Breadmaking Potential of Andean Roots and Tuber Starches from Ahipa (Pachyrhizus ahipa), Oca (Oxalis tuberosa), and Arracacha (Arracacia xanthorrhiza)
Authors: Dini Cecilia , Garzón Raquel , Rosell Cristina M. 
Published: August 2024

AbstractAim is to explore the breadmaking potential for gluten‐free goods of non‐conventional starches from Andean crops ahipa, oca, and arracacha. Their characteristics and performance in breadmaking are compared with those of cassava, taken as a reference for conventional gluten‐free root starch. Physicochemical properties of breads are studied along with the pasting and thermal properties, composition, and α‐amylase hydrolysis of starches. Arracacha starch has the lowest amylose content (2.4%) and the highest water hydration (1.4 g g−1). Its batter shows adequate proofing, but the bread is highly adhesive, with dense crumb. Ahipa starch paste has the lowest peak, trough and final viscosities determined by rapid visco analyzer, and the highest hydrolysis rate (kRVA = 2.30 min−1). Its batter exhibits, along with oca, the highest volume increase during fermentation (193–197%), but structure collapses in the oven and no alveoli are observed in the crumb. Conversely, oca forms a crumb structure similar to cassava, but with higher cell density (131 alveoli cm−2), cohesiveness (0.95), and resilience (0.65) than the latter (71 alveoli cm−2, 0.88, and 0.45, respectively). Oca starch has lower pasting temperature (64 °C) and the starch paste has similar hydrolysis rate (kRVA = 1.92 min−1) compared to cassava (71.9 °C and 2.08 min−1, respectively), making it a suitable option for providing gluten‐free yeast‐leavened breads with improved technological properties and a comparable glycemic index.
Balancing intrinsic properties of cathode materials allows high performance for protonic ceramic fuel cells
Authors: Yin Yanru , Liu Bo , Yan Dong , Li Jian , Jia Lichao 
Published: August 2024

AbstractThe cathode performance significantly impacts the overall performance of protonic ceramic fuel cells (PCFCs). Many properties of the material, such as oxygen vacancies, protonation, charge carrier transport abilities, and surface oxygen reduction reaction activity, can affect cathode performance. However, which parameter has more weight is still being debated. In this work, we use Ba0.5Sr0.5Zr0.25Fe0.65X0.1O3 as a case study (X = Zn, Cu, Mn, Ni, and Co). First‐principle calculations and experimental research are used to study and compare the critical parameters that determine cathode performance. It is discovered that no dopant can improve all the properties of the material. Balancing distinct intrinsic properties is a viable and rational approach. The more balanced, the better performance. When compared to other dopants, nickel dopant is shown to be the most effective in the Ba0.5Sr0.5Zr0.25Fe0.65X0.1O3 material system, allowing a high fuel cell performances of 1862, 1450, and 1085 mW cm−2 at 700°C, 650°C, and 600°C, with a low polarization resistance of 0.041 Ω cm2 at 700°C, which is higher than the majority of cobalt‐free cathodes for PCFCs. The current study not only presents a promising cathode candidate, but more importantly, also an effective and fundamental methodology to design cathodes for PCFCs.
Picrasidine I Regulates Apoptosis in Melanoma Cell Lines by Activating ERK and JNK Pathways and Suppressing AKT Signaling
Authors: Shieu Mu‐Kuei , Lin Chia‐Chieh , Ho Hsin‐Yu , Lo Yu‐Sheng , Chuang Yi‐Ching , Hsieh Ming‐Ju 
Published: August 2024

ABSTRACTWorld Health Organization data indicate a continuous increase in melanoma incidence, with metastatic melanoma characterized by poor prognosis and drug resistance. The exploration of therapeutics derived from natural products remains an active area of in vitro research. The aim of this study was to determine the antitumor effects of picrasidine I, a natural compound extracted from Picrasma quassioides, against two melanoma cell lines. We selected two metastatic melanoma cell lines, HMY‐1 and A2058, for molecular studies, including Western blotting, 4′,6‐diamidino‐2‐phenylindole staining, and flow cytometry. Picrasidine I demonstrated cytotoxic effects against the HMY‐1 and A2058 melanoma cell lines. It induced cell cycle arrest in the sub‐G1 phase and downregulated cell cycle–related proteins (e.g., cyclin A2, D1, cyclin‐dependent kinases 4, and 6). In the intrinsic apoptosis pathway, picrasidine I activated proapoptotic proteins (e.g., Bax, Bak, t‐Bid, BimL/S) and suppressed the expression of antiapoptotic proteins (e.g., Bcl‐2, Bcl‐xL), with an observed increase in the quantity of depolarized cells. In addition, the apoptotic effects of picrasidine I were linked to the activation of the c‐Jun N‐terminal kinase and extracellular signal‐regulated kinase pathways and the inhibition of the protein kinase B signaling pathway. A human apoptosis array indicated claspin inhibition upon picrasidine I treatment, suggesting the potential involvement of picrasidine I in apoptosis and cell cycle regulation. Our findings suggest that picrasidine I has potential as a candidate for treating advanced melanoma, and thus these findings warrant further investigation. The modulation of claspin expression by picrasidine I could be investigated further as a potential biomarker to predict its efficacy in related to advanced stages of melanoma.
Chromosome‐scale Salvia hispanica L. (Chia) genome assembly reveals rampant Salvia interspecies introgression
Authors: Brose Julia , Hamilton John P. , Schlecht Nicholas , Zhao Dongyan , Mejía‐Ponce Paulina M. , Cruz‐Pérez Arely , Vaillancourt Brieanne , Wood Joshua C. , Edger Patrick P. , Montes‐Hernandez Salvador , de Rosas Guillermo Orozco , Hamberger Björn , Cibrian‐Jaramillo Angélica , Buell C. Robin 
Published: August 2024

AbstractSalvia hispanica L. (Chia), a member of the Lamiaceae, is an economically important crop in Mesoamerica, with health benefits associated with its seed fatty acid composition. Chia varieties are distinguished based on seed color including mixed white and black (Chia pinta) and black (Chia negra). To facilitate research on Chia and expand on comparative analyses within the Lamiaceae, we generated a chromosome‐scale assembly of a Chia pinta accession and performed comparative genome analyses with a previously published Chia negra genome assembly. The Chia pinta and Chia negra genome sequences were highly similar as shown by a limited number of single nucleotide polymorphisms and extensive shared orthologous gene membership. However, there is an enrichment of terpene synthases in the Chia pinta genome relative to the Chia negra genome. We sequenced and analyzed the genomes of 20 Chia accessions with differing seed color and geographic origin revealing population structure within S. hispanica and interspecific introgressions of Salvia species. As the genus Salvia is polyphyletic, its evolutionary history remains unclear. Using large‐scale synteny analysis within the Lamiaceae and orthologous group membership, we resolved the phylogeny of Salvia species. This study and its collective resources further our understanding of genomic diversity in this food crop and the extent of interspecies hybridizations in Salvia.