bluuebunny/crossref_metadata_2025_split huggingface dataset:
The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein
Authors: Zhang Dian , Li Jiawen , Zhang Chao , Xue Jinliang , Li Peihao , Shang Kai , Zhang Xiao , Lang Baoping 
Published: August 2024

Abstract
Many cancers exhibit resistance to chemotherapy, resulting in a poor prognosis. The transcription factor NRF2, activated in response to cellular antioxidants, plays a crucial role in cell survival, proliferation, and resistance to chemotherapy. This factor may serve as a promising target for therapeutic interventions in esophageal carcinoma. Recent research suggests that NRF2 activity is modulated by ubiquitination mediated by the KEAP1-CUL3 E3 ligase complex, highlighting the importance of deubiquitination. However, the specific deubiquitinase responsible for regulating NRF2 in esophageal cancer remains unknown. In this study, a novel regulator of the NRF2 protein, Ubiquitin-Specific Protease 35 (USP35), has been identified. Mechanistically, USP35 modulates NRF2 stability through enzymatic deubiquitination. USP35 interacts with NRF2 and facilitates its deubiquitination. Knockdown of USP35 leads to a notable increase in NRF2 levels and enhances the sensitivity of cells to chemotherapy. These findings suggest that the USP35-NRF2 axis is a key player in the regulation of therapeutic strategies for esophageal cancer.
Medicines as Subjects: A Corpus-Based Study of Subjectification in Antimicrobial Resistance (AMR) Policy
Authors: Saldanha Gabriela 
Published: August 2024

Abstract
The concept of subjectification plays a key role in Foucault’s theory of governmentality and has been an important tool for the analysis of policy discourses, for example, in the form of Bacchi’s (2009. Analysing Policy: What’s the Problem Represented to Be? Frenchs Forest, N.S.W.: Pearson Australia) ‘What’s the problem represented to be?’ methodology. In this article, I demonstrate how corpus analysis can complement Bacchi’s methodology to offer a systematic and sophisticated account of subjectification processes in policy discourse, using Antimicrobial resistance (AMR) policy as a case in point. I combine Bacchi’s methodology with van Leeuwen’s (2008. Discourse and Practice: New Tools for Critical Discourse Analysis. Oxford Studies in Sociolinguistics. Oxford: Oxford University Press) linguistic framework for the analysis of discourse as social praxis, and argue that both Bacchi and van Leeuwen’s methodologies contain an important limitation, which is the assumption that agency is necessarily human. Drawing on anthropological theories of agency, I propose a broader concept of subjectification which includes the process whereby human agency is represented as things. From this perspective, another reading of the results emerges, in which the main subjects are medicines, and the aim of the policy is to save medicines.
User-centric Smart City Services for People with Disabilities and the Elderly: A UN SDG Framework Approach
Authors: Vojinovic Iva , Panajotovic Tamara , Budimirovic Mikica , Jankovic Marija , Milic Dragan 
Published: August 2024

AbstractThe publication presents the result of extensive research analysing how we can make smart cities more sustainable and inclusive. The central problem was to explore the readiness to adopt inclusive smart services that can sustainably foster, primarily, the inclusion of people with disabilities and the elderly. The secondary audience included the general population, facilitating a comprehensive examination of the varying needs among these demographics. The methodology involved an online questionnaire, formulated based on the Unified Theory of Acceptance and Use of Technology 2 model, and administered to a diverse sample of 302 participants from developing countries, Serbia, Bosnia and Herzegovina, and Montenegro, ensuring a broad representation of gender, age, educational backgrounds, and disability statuses. Key findings indicate a positive inclination towards smart city services across all demographics, particularly among the elderly and people with disabilities. Factors such as ease of use, and opportunities for social engagement are key drivers in the adoption of smart technologies. Research shows that all groups are interested in using smart city services if these would provide extensive environmental information, thereby improving their quality of life. The research contributes to the field by providing actionable insights for policymakers and urban developers to create more accessible and sustainable city environments.
Biosynthesis, characterization, and investigation of cytotoxic activities of selenium nanoparticles utilizing Limosilactobacillus fermentum
Authors: Aminisough Seyed Amirhamzeh , Daneshjou Sara , Khajeh Khosro 
Published: August 2024

Abstract
The biosynthesis of selenium nanoparticles (SeNPs) is one of the methods used alongside other conventional methods for SeNP synthesis. In this research, we used the cell-free culture (CFC) of Limosilactobacillus fermentum for SeNP synthesis. We investigated the biosynthesis of SeNPs under various levels of temperature, pH, and Se4+ concentration and characterized the biosynthesized SeNPs using FE-SEM, energy-dispersive X-ray, Fourier transform infrared spectroscopy, X-ray diffraction, ultraviolet–visible spectroscopy (UV–Vis), and dynamic light scattering–zeta potential analyses to find nanoparticles with desirable properties. Also, the cellular toxicity of SeNPs against the MCF-7 cell line was analyzed. The scavenging activity of free radicals in CFC before and after SeNP synthesis was examined using the DPPH method. The selected SeNP has an average hydrodynamic radius of 92.52 nm and a polydispersity index of 0.134. This nanoparticle also has a mostly spherical shape, amorphous nature, and zeta potential of −32.2 mV. The toxicity of nanoparticles for MCF-7 was much lower than sodium selenite salt. It was also confirmed that during nanoparticle synthesis, the reducing ability of CFC significantly decreases. This research aimed to design a safe, cheap, and eco-friendly protocol for the biosynthesis of SeNPs using the CFC of Limosilactobacillus fermentum. As a result, SeNPs possess great potential for further exploration in the realm of biomedicine.
Visible light communication optical FBMC-OQAM PAPR reduction using FHT-PTR algorithm for beyond 5G system
Authors: Gour Nidhi , Yadav Surendra , Kumar Arun 
Published: August 2024

Abstract
This paper addresses the reduction of peak-to-average power ratio (PAPR) in optical filter bank multicarrier (FBMC) with offset quadrature amplitude modulation (OQAM) using a fast Hadamard transform (FHT) centered partial transmit sequence (PTS) algorithm. High PAPR in FBMC-OQAM systems can cause non-linear distortions in optical transmitters, such as LEDs, leading to signal degradation. The proposed FHT-PTS algorithm effectively mitigates this issue by dividing the data symbols into disjoint subsets, applying phase rotations, and performing inverse FHT to generate multiple candidate sequences. The sequence with the lowest PAPR is selected for transmission. This technique ensures significant PAPR reduction while maintaining acceptable bit error rate (BER) performance. Simulation results demonstrate that the FHT-PTS algorithm achieves substantial PAPR reduction gain of 3 dB–6 dB compared to conventional PTS and other existing methods. The power spectrum density (PSD) analysis shows that the spectral efficiency of the FBMC-OQAM system is preserved, with minimal out-of-band emissions. The FHT operations significantly reduce the complexity compared to traditional Fourier transform-based methods, making the algorithm more feasible for real-time applications.
Diabetes and CFAP126 gene mutation; are they really linked together?
Authors: Arshad Kashan , Naseem Aamir , Hussain Syed Saddam , Mehak Noor-ul-ain , Butt Awais Muhammad , Aftab Sommayya , Saeed Anjum , Cheema Huma Arshad 
Published: August 2024

Abstract

Objectives
We are reporting a rare case series of 2 siblings and their mother with diabetes having a CFAP126 gene mutation.

Case presentation
Two female siblings, presented with incidental hyperglycemia at the ages of 16 and 13. They had a strong family history of diabetes on the maternal side. The systemic examination was unremarkable. Sibling 1 had HbA1C of 12.3 % with insulin and C-peptide levels of 6.6 IU/L and 1.8 ng/mL, respectively. Sibling 2 had an HbA1C of 12.6 %, an insulin level of 7.3 IU/L, and a C-peptide level of 2.02 ng/mL. Anti-GAD-65 and IA2 antibodies were negative. Mother also shared similar clinical processes and exhibited comparable biochemical changes related to glucose metabolism with elevated HbA1C levels and negative autoimmune markers (anti-GAD65 and IA2 antibodies). Whole exome sequencing (WES) turned out to be negative for MODY variants but revealed a rare heterozygous mutation in the CFAP126 gene (c.310A>T p. (Lys104*) in this family including both siblings and mother. The pathogenicity prediction tool MutationTaster® classified the mutation as disease causing. Oral glibenclamide remarkably reduced insulin requirements and improved HbA1C levels.

Conclusions
This rare genetic mutation is likely associated with diabetes and possibly a novel marker for a yet to be identified type of diabetes, that is responsive to oral sulfonylureas. The influence of this gene on insulin secretion needs to be confirmed through future research.
A basketball paradox: exploring NBA team defensive efficiency in a positionless game
Authors: South Charles 
Published: August 2024

Abstract
In the last decade, the offensive and defensive philosophies employed by teams in the National Basketball Association (NBA) have changed substantially. As a result, most players can no longer be classified into only one of the five traditional positions (PG, SG, SF, PF, C) and instead spend a percentage of their playing time at multiple positions, making positional data compositional. Further, given the desirability for versatile players, an argument can be made that traditional positions themselves are archaic. Using data from the 2016–17, 2017–18, and 2018–19 seasons, I explore how Bayesian hierarchical models can be used to estimate team defensive strength in three ways. First, only considering players classified by their majority traditional position. Second, by using compositional traditional positional data. Third, using compositional data from modern positions (archetypes) defined by fuzzy k-means clustering. I find that the fuzzy k-means approach leads to a modest improvement in both the root mean squared error and median 95 % posterior predictive interval width for the test data, and, more importantly, identifies 11 modern archetypes that, when combined, are correlated with team win total and adjusted team defensive rating. The modern archetype compositions can be used by stakeholders to better understand team defensive strength.
Dynamical investigation of the perturbed Chen–Lee–Liu model with conformable fractional derivative
Authors: Das Nilkanta , Saha Ray S. 
Published: August 2024

Abstract
This study focuses on the investigation of the perturbed Chen–Lee–Liu model with conformable fractional derivative by the implementation of the generalized projective Riccati equations technique. The proposed method uses symbolic computations to provide a dynamic and powerful mathematical tool for addressing the governing model and yielding significant results. Numerous analytical solutions of the governing model, including bell-shaped soliton solutions, anti-kink soliton solutions, periodic solitary wave solutions and other solutions, have been constructed effectively utilizing this effective technique. The findings acquired from the governing model utilizing the suggested technique demonstrate that all results are novel and presented for the first time in this study. Solitons are of immense significance in the domain of nonlinear optics due to their inherent ability to preserve their shape and velocity during propagation. The study of the propagation and the dynamical behaviour of the derived results have been explored by representing them graphically through 3D, density, and contour plots with different selections of arbitrary parameter values. The solitons acquired from the proposed model can provide significant advantages in the field of fiber-optic transmission technology. The obtained results demonstrate that the suggested approach is extremely promising, straightforward, and efficient. Furthermore, this approach may be effectively used in numerous emerging nonlinear models found in the fields of applied sciences and engineering.
Innovative Prozessketten in der Produktion
Authors: Zinnel Laura , Riegger Felix , Bloier Magdalena , Kick Laura , Zäh Michael F. 
Published: August 2024

Abstract
The hybrid process chain, consisting of wire arc additive manufacturing and post-processing, is a promising alternative to many established process chains but brings new challenges to the product development process. In several research projects at the Institute for Machine Tools and Industrial Management (iwb) at the Technical University of Munich, existing competencies in hybrid manufacturing are further developed. These research projects aim to enable hybrid manufacturing for new applications and to facilitate stable processes.
Flittergratvermeidung durch Dichtungsentwicklung
Authors: Doede Nils , Kriwall Mareile , Stonis Malte , Behrens Bernd-Arno 
Published: August 2024

Abstract
A major advantage of flashless precision forging is the saving of resources by avoiding excess material. Especially materials with good flow properties, such as aluminum, sometimes lead to the formation of thin flash. Seals have been developed and experimentally tested to prevent thin flash, i.e. the flow of material into tool gaps. The study presented shows the effectiveness of different sealing materials and the ideal sealing geometry.
Dimensionierung von Lokalisierungsankern in Produktionssystemen
Authors: Wilsky Philipp , Clausnitzer Yvonne , Riedel Ralph 
Published: August 2024

Abstract
Localisation technologies in production environments require the positioning of anchors in the room. This article presents a planning approach that enables the necessary infrastructure to be quantified. To this end, we will show which localization technologies are used and explain from a scientific and practical perspective how the anchors are planned in a room. Finally, a practicable procedure including recommendations for action is presented, which should enable companies to carry out their own planning.
Post-Processing von additiv gefertigten Bauteilen
Authors: Köntopf Jakob , Reder Waldemar , Merkel Matthias , Uhlmann Eckart 
Published: August 2024

Abstract
The post-processing of additively manufactured metallic components is primarily performed manually, often resulting in insufficient component quality and high cost. The development of an automated process for removing particle adhesions using continuous and pulsed pure water jets offers a solution. This article describes the suitability of the process and the influence of the acting water jet forces as a function of the relevant process parameters.
Oberflächenqualität beim Schleifen von CFK
Authors: Brouschkin Alexander , Otto Niklas , Möller Carsten , Hendrik Dege Jan 
Published: August 2024

Abstract
The use of carbon fibre-reinforced polymers in high-performance electric motors enables higher levels of efficiency and system rigidity. The demands on the surface quality of the individual components are so high that they can only be achieved by grinding processes. This paper investigates the influence of fibre orientation and abrasive grain size on the surface roughness during side-face grinding of CFRP.
A Modified Rowe Cell with Bender Elements for Small Strain Shear Modulus Measurements
Authors: Almukashfi Abdalla Mustafa Abdalla , Castellanza Ricardo , Gomes Correia Antonio , Arroyo Marcos , Zuretti Carlo , Bendea Daniela , Moldovan Ionut Dragos 
Published: August 2024

Abstract
The small strain shear modulus (G0) is an important characteristic of geomaterials. Its laboratory measurements are very frequently based on bender element transducers installed in different geotechnical apparatuses. Despite their widespread use, there is room to improve the precision, reproducibility, and robustness of bender element measurements, which are currently hampered by an oversimplified interpretation model of the test. Aspects such as transducer directivity, apparatus-induced size effects, and boundary reflectivity are poorly understood and accounted for. This work presents a novel modified Rowe cell apparatus specifically designed to obtain experimental data relevant to those features. The modified Rowe cell uses transmitter and receiver bender elements on the same boundary of the sample, performing dynamic measurements in echo mode with variable initial specimen size. Additionally, the modified Rowe cell endorses the flexible installation of the receivers and enables the use of multiple receivers, with distinct orientations. Furthermore, the modified Rowe cell gives the option of using different boundary conditions at the reflecting end to test the dynamic properties of usual geotechnical testing apparatus interfaces such as (semi-) rigid enclosures and flexible membranes. A systematic reliability study of the bender element measurements on the modified Rowe cell is presented, along with some illustrative examples of the capabilities of the apparatus.
Discursivizações sobre crenças no ensino e na aprendizagem de Língua Inglesa em um artigo acadêmico-científico
Authors: Duarte Oliveira Pauliana , Sérgio Bertoldo Ernesto 
Published: August 2024

Este artigo objetiva investigar as análises de um articulista sobre crenças acerca do ensino e aprendizagem de Inglês em um artigo científico. A pergunta de pesquisa procurou responder qual funcionamento discursivo sustenta tais análises e quais os efeitos de sentido que decorrem desse funcionamento. Norteamo-nos pela seguinte hipótese: embora as análises do articulista se propusessem a identificar e/ou analisar as crenças do informante, indiciou-se que o articulista acabava por referendar as crenças. Isso, consequentemente, poderia apontar para uma possível constituição do articulista pelas mesmas crenças. O trabalho fundamentou-se na Análise de Discurso francesa. O corpus foi constituído por análises de um articulista sobre crenças e ensino e aprendizagem de Inglês. Pudemos verificar que, geralmente, o articulista também se constitui pelas mesmas crenças do informante. As análises apontaram para um funcionamento discursivo caracterizado como uma discursivização circular das crenças, pois, a discussão parece girar em torno dela mesma, dificultando a promoção de deslocamentos.
In-depth exploration of differences of sex development: 5-year experience in a tertiary center
Authors: Hssaini Mohamed , Abourazzak Sana , El Otmani Ihsane , Ahakoud Mohamed , Ameli Amina , Bouguenouch Laila , Bekkari Hicham 
Published: August 2024

Background
Differences/disorders of sex development (DSD) encompass a wide range of conditions. Their clinical spectrum and etiological diagnosis have not been reported in Moroccan patients.

Aims
The study aims to highlight the clinical spectrum, etiological diagnosis, and management of patients with DSD.

Subjects and methods
This is a retrospective study of all patients diagnosed with DSD under the age of 18 years, who were referred to the Pediatric Endocrinology Department and the Medical Genetics Laboratory at HASSAN II University Hospital of Fez between June 2018 and June 2023.

Results
Out of 57 patients, 54.4% (n = 31) were diagnosed with 46,XX DSD, the most common type, while 45.6% (n = 26) had 46,XY DSD. Patients with 46,XX DSD presented earlier than those with 46,XY DSD, at a median age of 0.08 years and 0.96 years, respectively. The most commonly reported complaint was atypical genitalia. At the first presentation, the sex of rearing was already assigned to 26 males and 27 females. All patients with 46,XX DSD were diagnosed with congenital adrenal hyperplasia (CAH) at a median age of diagnosis of 0.92 years. Of these, 11 patients were raised as males. Disorders of androgen action or synthesis were more common in XY patients (69.2%). The consanguinity rate was 46.5%, and there were 19 cases with a positive family history, with 10 siblings having died.

Conclusion
DSD are not rare in Morocco. Overall, CAH remains the most frequent DSD etiology. Molecular genetic analyses are needed to determine the accurate etiological distribution of DSD, especially in XY patients.
Utilization of sea buckthorn (Hippophaë rhamnoides L.) pomace as functional ingredient in apple juice
Authors: Furulyas D. , Szalóki-Dorkó L. , Máté M. , Stefanovits-Bányai É. 
Published: August 2024

AbstractThe utilization of sea buckthorn pomace (SBP) is attracting growing attention since it is valuable industrial waste. This pomace can find usage as a functional ingredient of food because it contains bioactive, health-promoting components, but to our knowledge, few scientists have so far studied utilization of the antimicrobial activity of fruit pomace. The study aims are to broaden our knowledge of antioxidant and antimicrobial status of SBP by utilizing pomace as a functional apple juice ingredient and by monitoring the antioxidant capacity, the total polyphenol content and microbial changes that occur during the storage of juice samples. Our results of this study highlight that the importance of the utilization of SBP because the results reported here provide further evidence that SBP can contribute to increasing the content of valuable components in apple juice samples and inhibiting the growth of microorganisms during storage.