bluuebunny/crossref_metadata_2025_split huggingface dataset:
How are Long-Covid, Post-Sepsis-Syndrome and Post-Intensive-Care-Syndrome related? A conceptional approach based on the current research literature
Authors: Fleischmann-Struzek Carolin , Joost Franka E. A. , Pletz Mathias W. , Weiß Björn , Paul Nicolas , Ely E. Wesley , Reinhart Konrad , Rose Norman 
Published: August 2024

AbstractLong-Covid (LC), Post-Sepsis-Syndrome (PSS) and Post-Intensive-Care-Syndrome (PICS) show remarkable overlaps in their clinical presentation. Nevertheless, it is unclear if they are distinct syndromes, which may co-occur in the same patient, or if they are three different labels to describe similar symptoms, assigned on the basis on patient history and professional perspective of the treating physician. Therefore, we reviewed the current literature on the relation between LC, PSS and PICS. To date, the three syndromes cannot reliably be distinguished due similarities in clinical presentation as they share the cognitive, psychological and physical impairments with only different probabilities of occurrence and a heterogeneity in individual expression. The diagnosis is furthermore hindered by a lack of specific diagnostic tools. It can be concluded that survivors after COVID-19 sepsis likely have more frequent and more severe consequences than patients with milder COVID-19 courses, and that are some COVID-19-specific sequelae, e.g. an increased risk for venous thromboembolism in the 30 days after the acute disease, which occur less often after sepsis of other causes. Patients may profit from leveraging synergies from PICS, PSS and LC treatment as well as from experiences gained from infection-associated chronic conditions in general. Disentangling molecular pathomechanisms may enable future targeted therapies that go beyond symptomatic treatment.
MST1R-targeted therapy in the battle against gallbladder cancer
Authors: Wang Wei , Huang Chao , Zhang Li , Yu Liqin , Liu Yangming , Wang Puxiongzhi , Xia Rongmu 
Published: August 2024

Abstract
Background
Gallbladder cancer (GBC) is characterized by high mortality rate. Our study sought therapeutic candidates for GBC.

Results
Bioinformatics analysis identified significant upregulation of MST1R in GBC. In vitro experiments demonstrated that the MST1R inhibitor MGCD-265 effectively restrained GBC cell proliferation at lower concentrations. Additionally, it induced cycle arrest and apoptosis in GBC cells in a dose-dependent manner. Mouse models exhibited that MGCD-265 treatment significantly diminished the proliferative capacity of GBC-SD cells. Transcriptomics sequencing revealed significant transcriptome alterations, with 200 transcripts upregulated and 883 downregulated. KEGG and GO analyses highlighted enrichment in processes like cell adhesion and pathways such as protein digestion and absorption. Downstream genes analysis identified JMJD6 upregulation post-MGCD-265 treatment. In vivo experiments confirmed that combining MGCD-265 with the JMJD6 inhibitor SKLB325 enhanced the anticancer effect against GBC.

Conclusion
Overall, targeting MST1R and its downstream genes, particularly combining MGCD-265 with SKLB325, holds promise as a therapeutic strategy for GBC.
Ketamine-assisted buprenorphine initiation: a pilot case series
Authors: Grande Lucinda A. , Hutch Tom , Jack Keira , Mironov Wendy , Iwuoha Jessica , Muy-Rivera Martin , Grillo Jacob , Martin Stephen A. , Herring Andrew 
Published: August 2024

AbstractBackgroundMany people with opioid use disorder who stand to benefit from buprenorphine treatment are unwilling to initiate it due to experience with or fear of both spontaneous and buprenorphine-precipitated opioid withdrawal (BPOW). An effective means of minimizing withdrawal symptoms would reduce patient apprehensiveness, lowering the barrier to buprenorphine initiation. Ketamine, approved by the FDA as a dissociative anesthetic, completely resolved BPOW in case reports when infused at a sub-anesthetic dose range in which dissociative symptoms are common. However, most patients attempt buprenorphine initiation in the outpatient setting where altered mental status is undesirable. We explored the potential of short-term use of ketamine, self-administered sublingually at a lower, sub-dissociative dose to assist ambulatory patients undergoing transition to buprenorphine from fentanyl and methadone.MethodsPatients prescribed ketamine were either (1) seeking transition to buprenorphine from illicit fentanyl and highly apprehensive of BPOW or (2) undergoing transition to buprenorphine from illicit fentanyl or methadone and experiencing BPOW. We prescribed 4–8 doses of sublingual ketamine 16 mg (each dose bioequivalent to 3–6% of an anesthetic dose), monitored patients daily or near-daily, and adjusted buprenorphine and ketamine dosing based on patient response and prescriber experience.ResultsOver a period of 14 months, 37 patients were prescribed ketamine. Buprenorphine initiation was completed by 16 patients, representing 43% of the 37 patients prescribed ketamine, and 67% of the 24 who reported trying it. Of the last 12 patients who completed buprenorphine initiation, 11 (92%) achieved 30-day retention in treatment. Most of the patients who tried ketamine reported reduction or elimination of spontaneous opioid withdrawal symptoms. Some patients reported avoidance of severe BPOW when used prophylactically or as treatment of established BPOW. We developed a ketamine protocol that allowed four of the last patients to complete buprenorphine initiation over four days reporting only mild withdrawal symptoms. Two patients described cognitive changes from ketamine at a dose that exceeded the effective dose range for the other patients.ConclusionsKetamine at a sub-dissociative dose allowed completion of buprenorphine initiation in the outpatient setting in the majority of patients who reported trying it. Further research is warranted to confirm these results and develop reliable protocols for a range of treatment settings.
In what ways do AI techniques propel decision-making amidst volatility? Annotated bibliography perspectives
Authors: Zambrano Manzur Bryan N. , Espinoza Bazán Fabián A. , Novoa-Hernández Pavel , Cruz Corona Carlos 
Published: August 2024

AbstractThis research presents a systematic review and approximation, from 2018 to 2023, of how Artificial Intelligence can support decision-making processes when business managers have to resolve between multiple alternatives for the development of new businesses using Agile Frameworks; and as well, will be addressed from the genesis concepts such as VUCA, Agile Mindset, Infinite Game Theory, Agile Frameworks, Innovation, Artificial Intelligence among others with the aim of identifying research gaps in the decision-making process under changing environments. Most of the analyzed studies are focused on Infinity Games theory to better understand innovation processes linked from early stages to deployment phases of products. Furthermore, this paper analyzes AI techniques for decision-making under volatile circumstances and raises 5 research questions that from a logical and chronological perspective in development are resolved during the research. It is important to highlight that AI-related solutions are typically used to make informed decisions; however, few studies adopt AI to support the decision-making process in unstable environments.
Exploring drivers of self-treatment with antibiotics in three agricultural communities of northern Tanzania
Authors: Loosli Kathrin , Nasuwa Fortunata , Melubo Matayo , Mnzava Kunda , Matthews Louise , Mshana Stephen E. , Mmbaga Blandina T. , Muwonge Adrian , Davis Alicia , Lembo Tiziana 
Published: August 2024

Abstract
Background
Antimicrobial resistance (AMR) poses a significant global health threat, particularly in low- and middle-income countries (LMICs). Self-treatment with antibiotics, the practice of using antibiotics without professional guidance, is often considered an important contributor to the emergence and spread of AMR.

Method
This study investigated the drivers of self-treatment in three common types of agricultural communities in northern Tanzania. The research employed a comprehensive array of methods, including cross-sectional surveys (n = 790), interviews (n = 30) and observations (n = 178) targeting both antibiotic (human and animal) providers and users (patients and farmers). Qualitative interview data were analysed using a coding and association matrix, while descriptive analyses were performed on survey and observation data.

Results
Self-treatment with antibiotics was highly prevalent in all communities. Between 41.0% (self-reported) and 60.3% (observed) of human antibiotics were obtained without a prescription and we observed that veterinary antibiotics were regularly purchased in retail shops without referral by a professional. Structural deficiencies in the healthcare system drove this practice: limited access to healthcare facilities, medication stockouts and prolonged waiting times were identified as key factors. The absence of safety nets like insurance schemes further contributed to self-medication. Retail shops offered a convenient and cost-effective alternative when antibiotics were inaccessible or unaffordable. Notably, informal networks comprising treatment vendors, friends or neighbours, as well as personal experiences played a crucial role in guiding individuals in their self-treatment decisions by providing advice on treatment choice and modalities.

Conclusions
Addressing self-treatment requires a multi-faceted approach. Improving the availability and accessibility of antibiotics, enhancing healthcare services and involving retail vendors in antibiotic stewardship are essential. Structural issues like access to diagnostics and medicines must be tackled, alongside reducing barriers and incentivising individuals to use professional healthcare services. Training retail vendors to sell specific first-line antibiotics over the counter with guidance on appropriate usage should be considered. Such bottom-up interventions will enable sustainable promotion of responsible antibiotic use, mitigating AMR emergence and securing a healthier future for all.
Prokaryotic-virus-encoded auxiliary metabolic genes throughout the global oceans
Authors: Tian Funing , Wainaina James M. , Howard-Varona Cristina , Domínguez-Huerta Guillermo , Bolduc Benjamin , Gazitúa Maria Consuelo , Smith Garrett , Gittrich Marissa R. , Zablocki Olivier , Cronin Dylan R. , Eveillard Damien , Hallam Steven J. , Sullivan Matthew B. 
Published: August 2024

Abstract
Background
Prokaryotic microbes have impacted marine biogeochemical cycles for billions of years. Viruses also impact these cycles, through lysis, horizontal gene transfer, and encoding and expressing genes that contribute to metabolic reprogramming of prokaryotic cells. While this impact is difficult to quantify in nature, we hypothesized that it can be examined by surveying virus-encoded auxiliary metabolic genes (AMGs) and assessing their ecological context.

Results
We systematically developed a global ocean AMG catalog by integrating previously described and newly identified AMGs and then placed this catalog into ecological and metabolic contexts relevant to ocean biogeochemistry. From 7.6 terabases of Tara Oceans paired prokaryote- and virus-enriched metagenomic sequence data, we increased known ocean virus populations to 579,904 (up 16%). From these virus populations, we then conservatively identified 86,913 AMGs that grouped into 22,779 sequence-based gene clusters, 7248 (~ 32%) of which were not previously reported. Using our catalog and modeled data from mock communities, we estimate that ~ 19% of ocean virus populations carry at least one AMG. To understand AMGs in their metabolic context, we identified 340 metabolic pathways encoded by ocean microbes and showed that AMGs map to 128 of them. Furthermore, we identified metabolic “hot spots” targeted by virus AMGs, including nine pathways where most steps (≥ 0.75) were AMG-targeted (involved in carbohydrate, amino acid, fatty acid, and nucleotide metabolism), as well as other pathways where virus-encoded AMGs outnumbered cellular homologs (involved in lipid A phosphates, phosphatidylethanolamine, creatine biosynthesis, phosphoribosylamine-glycine ligase, and carbamoyl-phosphate synthase pathways).

Conclusions
Together, this systematically curated, global ocean AMG catalog and analyses provide a valuable resource and foundational observations to understand the role of viruses in modulating global ocean metabolisms and their biogeochemical implications.
Advancing the art of mosquito control: the journey of the sterile insect technique against Aedes aegypti in Cuba
Authors: Gato René , Menéndez Zulema , Rodríguez Misladys , Gutiérrez-Bugallo Gladys , del Carmen Marquetti María 
Published: August 2024

Abstract
Background
Aedes aegypti, the primary vector of dengue, chikungunya, and Zika viruses, poses a significant public health threat worldwide. Traditional control methods using insecticides are increasingly challenged by resistance and environmental concerns. The sterile insect technique (SIT) offers an eco-friendly alternative that has been successfully applied to other insect pests. This article aims to briefly review Ae. aegypti management in Cuba, highlighting the accomplishments, challenges, and future directions of the SIT.

Main body
Here we provide a brief summary of the extensive history of Ae. aegypti control efforts in Cuba. After a successful eradication campaign in the 1980s, a resurgence of dengue cases has been observed in recent years, suggesting that traditional control methods may have limited effectiveness under current conditions. In response, Cuba initiated a phased approach to develop and evaluate the feasibility of SIT for Ae. aegypti control, starting in 2008. Initial research focused on Ae. aegypti mating behavior and sterilization methods, followed by successful laboratory and semi-field trials that demonstrated population suppression. The first open-field trial in 2020 confirmed the efficacy of the SIT in reducing Ae. aegypti populations under real-world conditions. Currently, the research is in a phase involving a cluster-randomized superiority-controlled trial. This planned trial will compare the standard vector control program with the same program augmented by the SIT, aiming to assess the impact of the SIT on dengue incidence as the primary outcome. Implementing robust epidemiological trials to evaluate the effectiveness of the SIT is complex due to potential spillover effects from mosquito and human movement across study areas. Additionally, conducting the SIT requires significant development and operational investments. Despite these challenges, the ongoing Cuban trial holds promise for establishing the SIT as an effective and sustainable tool for Ae. aegypti control and for reducing the burden of mosquito-borne diseases.

Conclusions
The phased evaluation conducted in Cuba confirms the efficacy of the SIT against Ae. aegypti, highlighting its potential for sustainable mosquito-borne disease management. The effective implementation of multi-site trials will be crucial in providing evidence of the potential of the sterile insect technique as part of a strategy to reduce the incidence of arboviral diseases.

Graphical Abstract
The state of foresight in small and medium enterprises: literature review and research agenda
Authors: Dörr Ulrike-Sabine , Schönhofer Gerhard , Schwarz Jan Oliver 
Published: August 2024

AbstractSmall and medium-sized enterprises (SMEs) are the backbone of many economies. In today's world of VUCA (Volatility, Uncertainty, Complexity, Ambiguity), SMEs face diverse challenges to survive and stay competitive. SMEs must prepare themselves for these challenges by practicing foresight. However, foresight, and especially corporate foresight, has been conceptualized and researched in the context of large corporations. Applying foresight in SMEs is therefore complicated by the question of how to implement foresight in the context of SMEs given their specific requirements and limitations. This article provides an overview on the literature on the application of foresight in SMEs is, along with a summary of the extent to which SMEs conduct foresight from an organizational and individual perspective. Besides offering a compendium on the state of foresight in SMEs, a research agenda is formulated, incorporating the idea of a toolbox tailored to SMEs based on existing approaches and prior works.
Enhancing point cloud registration with transformer: cultural heritage protection of the Terracotta Warriors
Authors: Wang Yong , Zhou Pengbo , Geng Guohua , An Li , Zhou Mingquan 
Published: August 2024

Abstract
Point cloud registration technology, by precisely aligning repair components with the original artifacts, can accurately record the geometric shape of cultural heritage objects and generate three-dimensional models, thereby providing reliable data support for the digital preservation, virtual exhibition, and restoration of cultural relics. However, traditional point cloud registration methods face challenges when dealing with cultural heritage data, including complex morphological and structural variations, sparsity and irregularity, and cross-dataset generalization. To address these challenges, this paper introduces an innovative method called Enhancing Point Cloud Registration with Transformer (EPCRT). Firstly, we utilize local geometric perception for positional encoding and combine it with a dynamic adjustment mechanism based on local density information and geometric angle encoding, enhancing the flexibility and adaptability of positional encoding to better characterize the complex local morphology and structural variations of artifacts. Additionally, we introduce a convolutional-Transformer hybrid module to facilitate interactive learning of artifact point cloud features, effectively achieving local–global feature fusion and enhancing detail capture capabilities, thus effectively handling the sparsity and irregularity of artifact point cloud data. We conduct extensive evaluations on the 3DMatch, ModelNet, KITTI, and MVP-RG datasets, and validate our method on the Terracotta Warriors cultural heritage dataset. The results demonstrate that our method has significant performance advantages in handling the complexity of morphological and structural variations, sparsity and irregularity of relic data, and cross-dataset generalization.
Cartographies of warfare in the Indian subcontinent: Contextualizing archaeological and historical analysis through big data approaches
Authors: Smith Monica L. , Newton Connor 
Published: August 2024

AbstractSome of the most notable human behavioral palimpsests result from warfare and its durable traces in the form of defensive architecture and strategic infrastructure. For premodern periods, this architecture is often understudied at the large scale, resulting in a lack of appreciation for the enormity of the costs and impacts of military spending over the course of human history. In this article, we compare the information gleaned from the study of the fortified cities of the Early Historic period of the Indian subcontinent (c. 3rd century BCE to 4th century CE) with the precolonial medieval era (9-17th centuries CE). Utilizing in-depth archaeological and historical studies along with local sightings and citizen-science blogs to create a comprehensive data set and map series in a “big-data” approach that makes use of heterogeneous data sets and presence-absence criteria, we discuss how the architecture of warfare shifted from an emphasis on urban defense in the Early Historic period to an emphasis on territorial offense and defense in the medieval period. Many medieval fortifications are known from only local reports and have minimal identifying information but can still be studied in the aggregate using a least-shared denominator approach to quantification and mapping.
Expectations of and perceived need for civil war in the USA: findings from a 2023 nationally representative survey
Authors: Wintemute Garen J. , Li Yueju , Velasquez Bradley , Crawford Andrew , Reeping Paul M. , Tomsich Elizabeth A. 
Published: August 2024

Abstract
Background
Surveys have found concerningly high levels of agreement that the United States will experience civil war soon. This study assesses variation in expectation of and perceived need for civil war with respondent sociopolitical characteristics, beliefs, firearm ownership, and willingness to engage in political violence.

Methods
Findings are from Wave 2 of a nationally representative annual longitudinal survey of members of the Ipsos KnowledgePanel, conducted May 18–June 8, 2023. All respondents to 2022’s Wave 1 who remained in KnowledgePanel were invited to participate. Outcomes are expressed as weighted proportions and adjusted prevalence differences, with p-values adjusted for the false discovery rate and reported as q-values.

Results
The completion rate was 84.2%; there were 9385 respondents. After weighting, half the sample was female (50.7%, 95% CI 49.4%, 52.1%); the weighted mean (± standard deviation) age was 48.5 (25.9) years. Approximately 1 respondent in 20 (5.7%, 95% CI 5.1%, 6.4%) agreed strongly or very strongly that “in the next few years, there will be civil war in the United States.” About 1 in 25 (3.8%, 95% CI 3.2%, 4.4%), and nearly 40% (38.4%, 95% CI 32.3%, 44.5%) of those who strongly or very strongly agreed that civil war was coming, also agreed strongly or very strongly that “the United States needs a civil war to set things right.” Expectation of and perceived need for civil war were higher among subsets of respondents who in Wave 1 were more willing than others to commit political violence, including MAGA Republicans, persons in strong agreement with racist beliefs or statements of the potential need for violence to effect social change, persons who strongly approved of specified extreme right-wing political organizations and movements, firearm owners who purchased firearms in 2020 or later, and firearm owners who carried firearms in public all or nearly all the time.

Conclusions
In 2023, the expectation that civil war was likely and the belief that it was needed were uncommon but were higher among subsets of the population that had previously been associated with greater willingness to commit political violence. These findings can help guide prevention efforts.