bluuebunny/crossref_metadata_2025_split huggingface dataset:
Key successful factors of knowledge management for university students using e‐portfolios: Approach of Fuzzy Delphi and Fuzzy AHP
Authors: Chang Chi‐Cheng , Liang Chaoyun , Shu Kuen‐Ming , Tsai Cheng‐Wei 
Published: April 2015

ABSTRACTThe key successful factors (KSFs) of knowledge management for university students using e‐portfolio were established in the present study based on the Fuzzy Delphi method (FDM) and Fuzzy Analytic Hierarchy Process (FAHP). According to experts, the KSFs of KM using e‐portfolio included knowledge sharing, innovation, acquisition, application, and accumulation. Detailed sub‐KSFs were developed based on the activities of the e‐portfolios including reflection, work revision, self‐assessment on works, arrangement of learning content, teacher feedback, modeling, communication, and discussion. Each KSF and sub‐KSF was weighted and ranked and had an acceptable reliability and validity. Among these sub‐KSFs, reflection had the highest weight, followed by work revision, implying that reflection had the greatest impact on knowledge management. © 2015 Wiley Periodicals, Inc. Comput. Appl. Eng. Educ. Comput Appl Eng Educ 23:673–681, 2015; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21640
The signal game: Missions and playground to motivate vocational education students toward periodic signals
Authors: Marzo Asier 
Published: April 2015

ABSTRACTVocational Education is a modality of regulated learning that emphasizes practical and applied skills over theoretical approaches. Nevertheless, some theoretical subjects are contained in the program. These subjects are not well perceived by the students, even when the concepts taught in them represent physically perceptible phenomena. The Signal Game represents periodical signals as audible sounds to help students learning concepts such as frequency, amplitude and summation, or multiplexing of signals. To play the game, the students can drag and wire blocks visually and thus it does not require a strong theoretical background. The game allows the users to play through sequential missions. Thereby, the student can learn and assimilate the concepts gradually. The other game mode is the playground, in it the students have all the possibilities enabled. A user study revealed that the game increased intrinsic motivation and that the students acquired applicable concepts about signal theory. © 2015 Wiley Periodicals, Inc. Comput. Appl. Eng. Educ. Comput Appl Eng Educ 23:771–777, 2015; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21649
Both serum 25‐hydroxyvitamin D and calcium levels may increase the risk of incident prostate cancer in Caribbean men of African ancestry
Authors: Jackson Maria D. , Tulloch‐Reid Marshall K. , Lindsay Carole M. , Smith Garrett , Bennett Franklyn I. , McFarlane‐Anderson Norma , Aiken William , Coard Kathleen C. M. 
Published: April 2015

AbstractCirculating 25‐hydroxyvitamin D [25(OH)D] concentrations have been associated with both higher and lower risk of prostate cancer (PCa), whereas elevated levels of circulating calcium has been related to higher risks. However, there are few studies that account for effects of both calcium and 25(OH)D concentrations on incident PCa in a black population. We examined these relationships in a case–control study of men 40–80 years old with newly diagnosed, histologically confirmed PCa in Jamaica, a tropical country. Mean serum calcium concentrations was higher among cases (2.32 ± 0.19 mmol/L) than controls, (2.27 ± 0.30 mmol/L) (P = 0.023) however, there were no differences in 25(OH)D by cancer status (cases, 33.67 ± 12.71 ng/mL; controls (32.25 ± 12.59 ng/mL). Serum calcium was not correlated with 25(OH)D (partial correlation: r, 0.06; P = 0.287). Multivariable‐adjusted models showed a positive linear relationship between PCa and serum calcium (OR, 1.12; CI, 1.00–1.25 per 0.1 nmol/L). Serum 25(OH)D concentration also showed a positive association with PCa (OR, 1.23; CI, 1.01–1.49 per 10 ng/mL). The odds of PCa in men with serum 25(OH)D tertile 2 was OR, 2.18; CI, 1.04–4.43 and OR, 2.47 CI, 1.20–4.90 for tertile 3 (Ptrend = 0.013). Dietary intakes of calcium showed no relationship with PCa. Despite the strong relationship between serum calcium and vitamin D the mechanism by which each affects prostate cancer risk in men of African ancestry needs additional investigation.
Persistent topology for cryo‐EM data analysis
Authors: Xia Kelin , Wei Guo‐Wei 
Published: April 2015

SummaryIn this work, we introduce persistent homology for the analysis of cryo‐electron microscopy (cryo‐EM) density maps. We identify the topological fingerprint or topological signature of noise, which is widespread in cryo‐EM data. For low signal‐to‐noise ratio (SNR) volumetric data, intrinsic topological features of biomolecular structures are indistinguishable from noise. To remove noise, we employ geometric flows that are found to preserve the intrinsic topological fingerprints of cryo‐EM structures and diminish the topological signature of noise. In particular, persistent homology enables us to visualize the gradual separation of the topological fingerprints of cryo‐EM structures from those of noise during the denoising process, which gives rise to a practical procedure for prescribing a noise threshold to extract cryo‐EM structure information from noise contaminated data after certain iterations of the geometric flow equation. To further demonstrate the utility of persistent homology for cryo‐EM data analysis, we consider a microtubule intermediate structure Electron Microscopy Data (EMD 1129). Three helix models, an alpha‐tubulin monomer model, an alpha‐tubulin and beta‐tubulin model, and an alpha‐tubulin and beta‐tubulin dimer model, are constructed to fit the cryo‐EM data. The least square fitting leads to similarly high correlation coefficients, which indicates that structure determination via optimization is an ill‐posed inverse problem. However, these models have dramatically different topological fingerprints. Especially, linkages or connectivities that discriminate one model from another, play little role in the traditional density fitting or optimization but are very sensitive and crucial to topological fingerprints. The intrinsic topological features of the microtubule data are identified after topological denoising. By a comparison of the topological fingerprints of the original data and those of three models, we found that the third model is topologically favored. The present work offers persistent homology based new strategies for topological denoising and for resolving ill‐posed inverse problems. Copyright © 2015 John Wiley & Sons, Ltd.
Experimental research of effects of different rotation radii on the growth rate of potassium dihydrogen phosphate crystals
Authors: Cheng Min , Kang Daoyuan , Zhang Xiaoli , Yin Huawei , Wang Yuhong 
Published: April 2015

Comparing with the traditional concentric rotation method (rotation radius is 0 cm), the effects of different rotation radii on the growth rate of KDP crystals were studied by experimental methods. It was found that with the increase of rotation radius from 0 cm, the growth rate of each direction of crystals first increased and then decreased in a size‐unchanged vessel. The smaller the distance between the crystal and vessel wall, the less the growth rate. This phenomenon was named the “wall collision effect”. Also, the value of growth rate reached a maximum when the rotation radius was about half of its allowable largest value in the size‐unchanged vessel. In addition, an increase of the rotation radius could improve the crystal growth rate under the same linear velocity of crystal movement. Finally, the uniformity of crystal growth has also been analyzed compared with the concentric rotation radius. It was found that the uniformity of crystal growth was best when the rotation radius was half of its allowable maximum value, and it was more conducive to the actual application of KDP crystals.
Outcomes and cost minimisation associated with outpatient parenteral antimicrobial therapy (OPAT) for foot infections in people with diabetes
Authors: Malone Matthew , West Dana , Xuan Wei , Lau Namson S. , Maley Michael , Dickson Hugh G. 
Published: April 2015

AbstractObjectiveTo determine clinical outcomes in patients with diabetic foot infections receiving outpatient parenteral antimicrobial therapy (OPAT), to evaluate cost savings from the use of OPAT and to analyse demographic, clinical and laboratory data that may predict OPAT failure.Research Design and MethodologyA retrospective cohort analysis was conducted between 1 January 2007 and 7 July 2012 at a tertiary referral hospital in metropolitan Sydney. Patients with diabetic foot infection were identified from the outpatient parenteral antimicrobial therapy database. Demographic, clinical, laboratory and operative report data were obtained from patient charts and electronic medical records. Potential cost savings were calculated on the estimated cost of expenditure versus the expected savings. Linear regression was used to explore outcomes associated with outpatient parenteral antimicrobial therapy failure.ResultsFifty‐nine patients were identified over the 5‐year study period. The outpatient parenteral antimicrobial therapy success rate for diabetic foot infections was 88%. Following the resolution of the primary episode of infection, new infective episodes within the study period were high (n = 26, 44%). Regression analysis of variables for OPAT failure failed to indicate any factors reaching statistical significance. A total of 1569 days were saved by using outpatient parenteral antimicrobial therapy for an estimated total cost saving of $983 645 or $16 672 per patient.ConclusionOutpatient intravenous therapy for diabetic foot infections is an effective mode of treatment that can contribute to significant healthcare savings. High re‐infection rates associated with diabetes foot ulceration in this population underline the need for close monitoring and management of these patients in multidisciplinary high‐risk foot setting. Copyright © 2015 John Wiley & Sons, Ltd.
Tandem Prins Cyclization for the Stereoselective Synthesis of the 4,5‐Diaryl‐hexahydropyrano[3,4‐c]chromene Skeleton of Calyxins I and J
Authors: Reddy Basi V. Subba , Reddy Mittapalli Ramana , Reddy Sama Gopal , Sridhar Balasubramanyan , Kumar Singarapu Kiran 
Published: April 2015

AbstractA Prins bicyclization strategy for the stereoselective synthesis of trans‐fused hexahydropyrano[3,4‐c]chromene derivatives in good to excellent yields has been developed. The synthetic versatility of this approach has been demonstrated in the synthesis of calyxin I and J analogues. This is the first example of the synthesis of hexahydropyrano[3,4‐c]chromene derivatives from (E)‐3‐[2‐(benzyloxy)phenyl]‐5‐phenylpent‐4‐en‐1‐ol (4b) and aldehydes.
Silver(I)‐Catalyzed Tandem Approach to β‐Oxo Amides
Authors: Vandavasi Jaya Kishore , Hsiao Cheng‐Tien , Hu Wan‐Ping , Boominathan Siva Senthil Kumar , Wang Jeh‐Jeng 
Published: April 2015

AbstractA facile and efficient AgI‐catalytic approach is reported for the first time to synthesize β‐oxo amides from β‐oxo esters a with broad substrate scope in good to excellent yields. Crossover and in situ NMR studies confirmed that the reaction occurred through a new pathway and not by the traditional condensation reaction. The key advantages of this method are the readily available starting materials, the air‐stable reaction, the simple protocol, and the environmental friendliness.
Total Synthesis of (±)‐8‐Oxo‐erythrinine, (±)‐8‐Oxo‐erythraline, and (±)‐Clivonine
Authors: He Maomao , Qu Chunrong , Ding Bingbing , Chen Hao , Li Yangyan , Qiu Guofu , Hu Xianming , Hong Xuechuan 
Published: April 2015

AbstractTotal syntheses of the erythrina alkaloids (±)‐8‐oxo‐erythrinine and (±)‐8‐oxo‐erythraline have been developed, based on a substrate‐controlled intramolecular 6‐exo‐trig selective radical spirocyclization that establishes the quaternary center of the B‐rings. An improved total synthesis of (±)‐clivonine has also been reported, based on an intramolecular 6‐endo‐trig free‐radical cyclization of a highly functionalized enamide, and a biomimetic ring‐switch of a lycorine‐type intermediate. These endo/exo‐selective sequences enabled us to rapidly assemble two different complex alkaloids from a common building block in an economical fashion.
Spot Market Volatility and Futures Trading: The Pitfalls of Using a Dummy Variable Approach
Authors: Bohl Martin T. , Diesteldorf Jeanne , Salm Christian A. , Wilfling Bernd 
Published: April 2015

AbstractThis study challenges the existing literature examining the impact of the introduction of index futures trading on the volatility of its underlying. To overcome econometric shortcomings of previously published work using the dummy variable approach, we employ a Markov‐switching‐GARCH technique. This approach endogenously identifies distinct volatility regimes rather than modeling an exogenously defined one‐step change in the volatility process. We investigate stock market volatility in France, Germany, Japan, the United Kingdom, and the United States. Our empirical results indicate that index futures trading does neither stabilize nor destabilize the underlying spot market. © 2015 Wiley Periodicals, Inc. Jrl Fut Mark 36:30–45, 2016
Change in therapeutic apheresis practices: Role of continuing medical education (CME)
Authors: Tiwari Aseem Kumar , Dara Ravi C. , Pandey Prashant , Arora Dinesh , Rawat Ganesh , Raina Vimarsh 
Published: April 2015

IntroductionAmerican society for apheresis (ASFA) publishes guidelines for therapeutic apheresis (TA) and physicians ordering TA procedures should be aware of the appropriate indications based on scientific evidence. Transfusion Medicine specialists (apheresis physicians) can steer physicians in right direction through CME on right indications, duration of therapy and replacement fluid. Therefore, authors reviewed, collated, and interpreted effect of formal CME interventions.Materials and MethodsRetrospective study was conducted in a large hospital in India. CME interventions to teach clinical and managerial aspects of TA were conducted in the first quarter of 2012. Sessions involved ASFA guidelines and recommendations for TA. Data was collected and changes in practice related to TA before (March 2010 to December 2011) and after (April 2012 to December 2013) the intervention was analyzed.ResultsSeventy‐three subjects participated in the interventions. Five hundred and eighty‐nine TA procedures were performed during study period; 214 procedures in 49 patients before intervention and 375 procedures in 84 patients after intervention. After intervention there was significant improvement in indications of category I (38.7% vs. 64.3%; P = 0.004), category II (22.5% vs. 16.6%), category III (12.2% vs. 11.9%), and category IV (6.1% vs. 2.4%; P = 0.0001). Significant reduction was seen in procedures not belonging to any category from 20.5% to 4.8% (P = 0.002). Change in practices was also observed in context of duration of therapy and replacement fluid.ConclusionCME intervention, based on the 2010 edition of ASFA guidelines for therapeutic apheresis appears to have had a positive impact on physicians TA practices. J. Clin. Apheresis 31:16–21, 2016. © 2015 Wiley Periodicals, Inc.
Hematopoietic progenitor cells collection in pediatric patients with brain tumor
Authors: Spínola Ana , Ferreira Sara , Amado Fátima , Lopes Sérgio , Roncon Susana 
Published: April 2015

AimTo analyze the efficacy and safety of hematopoietic progenitor cells (HPC) collections by leukapheresis in pediatric patients with brain tumors.ResultsBetween 2003 and 2014, we collected HPC from 19 children (12 boys/7 girls), median age at the diagnosis of 5 years old (<1–15 years old) and weight of 16.8 Kg (6.7–42). Diagnoses were Medulloblastoma (n = 10), Primitive Neuroectodermal Tumor (n = 5), Atypical Teratoid Rhabdoid Tumor (n = 3) and Secreting Germ Cell Tumor (n = 1). All patients performed leukapheresis by a central venous catheter, at the fifth day of mobilization with G‐CSF (median dose 11.7 µg/Kg/day), 9 of them with COBE® Spectra and 10 with Spectra Optia®. The anticoagulant used was ACD‐A, ratio of 14:1 or ACD‐A plus heparin, ratio 25:1. The tubing set was primed with a compatible, irradiated, leukodepleted and hematocrit adjusted packed red cells for all children <30 kg (n = 17). A median of 1.5 (1–3) leukapheresis per patient was performed with an average of 3 (1.5–5.4) blood volumes processed; 3 children did a second mobilization and one additional leukapheresis. The median number of CD34+ cells collected was 4.6 × 106/Kg (0.18–22.6) of patient body weight; 12 children collected for a tandem transplant. The median time between cell collection and infusion was 3 (0.6–9.1) months.ConclusionsHPC collection in children is an efficient and well tolerated technique, performed as an outpatient procedure. With the new mobilization schemes and leukapheresis technology, we can collect a high number of HPC allowing pediatric oncologist to establish more aggressive chemotherapy protocols hoping to improve patient outcome. J. Clin. Apheresis 31:22–28, 2016. © 2015 Wiley Periodicals, Inc.
Nonsuicidal Self‐Injury and Affect Regulation: Recent Findings From Experimental and Ecological Momentary Assessment Studies and Future Directions
Authors: Hamza Chloe A. , Willoughby Teena 
Published: April 2015

ContextAlthough research indicates that nonsuicidal self‐injury (NSSI) may be used as a form of emotion regulation, studies have largely relied on the use of retrospective self‐report data, which limits inferences about directionality of effects. Recently, researchers have started to employ lab‐based experimental (e.g., guided imagery, acute pain) and moment sampling approaches to the study of NSSI.MethodsIn the present study, we conducted a review of this recent literature, using several electronic databases (e.g., PsychINFO, ERIC, CINAHL).ResultsWe identified 18 studies that met our inclusion criteria. Findings indicated that the administration of pain was associated with decreases in negative affect among both self‐injurers and noninjurers, although these declines were more pronounced for self‐injurers in some studies.ConclusionsWe discuss findings within the context of two central theories (i.e., opponent‐process theory and distraction theory) and offer several recommendations for future research in this area.
Noninvasive investigation of exocrine pancreatic function: Feasibility of cine dynamic MRCP with a spatially selective inversion‐recovery pulse
Authors: Yasokawa Kazuya , Ito Katsuyoshi , Tamada Tsutomu , Yamamoto Akira , Hayashida Minoru , Tanimoto Daigo , Higaki Atsushi , Noda Yasufumi , Kido Ayumu 
Published: April 2015

PurposeTo investigate the feasibility of noncontrast‐enhanced cine dynamic magnetic resonance cholangiopancreatography (MRCP) with a spatially selective inversion‐recovery (IR) pulse for evaluating exocrine pancreatic function in comparison with the N‐benzoyl‐L‐tyrosyl‐p‐aminobenzoic acid (BT‐PABA) test as a pancreatic exocrine function test.Materials and MethodsTwenty subjects with or without chronic pancreatitis were included. MRCP with a spatially selective IR pulse was repeated every 15 seconds for 5 minutes to acquire a total of 20 images (cine‐dynamic MRCP). The median and mean frequency of the observation (the number of times) and the moving distance (mean secretion grading scores) of pancreatic juice inflow on cine‐dynamic MRCP were compared with a BT‐PABA test.ResultsThe urinary PABA excretion rate (%) had significant positive correlations with both the mean secretion grade (r = 0.66, P = 0.002) and frequency of secretory inflow (r = 0.62, P = 0.004) in cine dynamic MRCP. Both the mean frequency of observations of pancreatic secretory inflow (1.4 ± 1.6 times vs. 14.3 ± 4.2 times, P < 0.001) and the mean secretion grade (grade = 0.16 ± 0.24 vs. grade = 1.81 ± 0.81, P < 0.001) was significantly lower in the chronic pancreatitis group than in the normal subject group.ConclusionCine dynamic MRCP with a spatially selective IR pulse may have potential for estimating the pancreatic exocrine function noninvasively as a substitute for the BT‐PABA test. J. Magn. Reson. Imaging 2015;42:1266–1271.
Backpacking Through an Ontology of Becoming: A Never‐ending Cycle of Journeys
Authors: Tomazos Konstantinos 
Published: April 2015

AbstractBy adopting an ontological stance of becoming, this study traces qualitatively the journeys of contemporary backpacker tourists using the theoretical construct of the ‘Hero's Journey’ as a conceptual vehicle. This process allows for the development of a cyclical model of experience that illustrates the backpacker's experience in three stages of departure, initiation and return. This approach reveals the role that former backpackers play through the sharing of knowledge and the invaluable support they offer to novice backpackers through a network of support that is available to contemporary backpackers who choose to follow established backpacking trails. This never ending cycle of journeys becomes instrumental into the shaping of what this paper see as the common, collective consciousness of the backpacking experience and the evolution of the backpacking experience market. Copyright © 2015 John Wiley & Sons, Ltd.
Validating the Use of 137Cs Measurements to Derive the Slope Component of the Sediment Budget of a Small Rangeland Catchment in Southern Italy
Authors: Porto Paolo , Walling Desmond E. , La Spada Carmelo , Callegari Giovanni 
Published: April 2015

AbstractThe sediment budget is a key concept and tool for characterizing the mobilization, transfer and storage of fine sediment within a catchment. Caesium‐137 measurements can provide valuable information on gross and net erosion rates associated with sheet and rill erosion that can be used to establish the slope component of a catchment sediment budget. However, there is a need to validate the use of 137Cs measurements for this purpose, because their reliability has sometimes been questioned. The study reported focuses on a small (3·04 ha) steepland (mean slope 37%) catchment in Southern Italy. It exploits the availability of information on the medium‐term sediment output from the catchment provided by the construction of a reservoir at its outlet in 1978 and the existence of estimates of soil redistribution rates derived from 137Cs measurements made on 68 replicate soil cores collected from the slopes of a substantial proportion of the catchment in 2001, to validate the use of 137Cs measurements to construct the slope component of the catchment sediment budget. An additional 50 replicate soil cores were collected from the catchment slopes for 137Cs analysis, to complement the data already available. Nine cores collected from the area occupied by the reservoir were used to estimate the mean annual sediment input to the reservoir. In the absence of evidence that the poorly developed channel system in the catchment was either a significant sediment source or sink, it was possible to directly compare the estimate of net soil loss from the catchment slopes (7·33 Mg ha−1 y−1) with the estimate of sediment output from the catchment provided by the reservoir deposits (7·52 Mg ha−1 y−1). Taking account of the uncertainties involved, the close agreement of the two values is seen as providing a convincing validation of the use of 137Cs measurements to both estimate soil redistribution rates and as a basis for constructing the slope component of the sediment budget of a small catchment. Copyright © 2015 John Wiley & Sons, Ltd.
Vom Gewinn des Scheiterns
Authors: Huesmann David , Neidlinger Andreas , Reusch Nicola 
Published: April 2015

AbstractNegativ‐ und Nullresultate sind wichtig auf dem Weg zu neuen Erkenntnissen. Unerwartete Ergebnisse werden jedoch häufig nicht publiziert, weil die Untersuchungen scheinbar nicht erfolgreich waren. Das will das Journal of Unsolved Questions ändern und dient deshalb seit vier Jahren als Medium für solche Publikationen.