bluuebunny/crossref_metadata_2025_split huggingface dataset:
New ways of mitigating aldosterone in cardiorenal disease
Authors: Götzinger Felix , Kunz Michael , Lauder Lucas , Böhm Michael , Mahfoud Felix 
Published: July 2024

Abstract
Steroidal mineralocorticoid receptor antagonists (MRAs) bind to the mineralocorticoid receptor and antagonize the effects of aldosterone, which contributes to the development and progression of cardio- and renovascular diseases. Guidelines recommend steroidal MRAs in patients with heart failure with reduced or mildly reduced ejection fraction, as they reduce morbidity and mortality. In heart failure with preserved ejection fraction, MRAs have not convincingly shown to improve prognosis. Steroidal MRAs delay the progression of chronic kidney disease, reduce proteinuria and lower blood pressure in resistant hypertension but can induce hyperkalaemia. Due to their limited selectivity to the mineralocorticoid receptor, steroidal MRAs can cause significant adverse effects, i.e. libido loss, erectile dysfunction, gynaecomastia, and amenorrhoea, leading to low rates of persistance. Against this background, new avenues for developing non-steroidal, selective (ns)MRAs and aldosterone-synthase inhibitors have been taken. Finerenone has been shown to delay the progression of diabetic nephropathy and lower the incidence of heart failure hospitalizations in patients with chronic kidney disease and diabetes compared with placebo. Finerenone has therefore been recommended by the 2023 European Society of Cardiology Guidelines for the management of diabetes in patients with type 2 diabetes and chronic kidney disease. Further randomized controlled trials assessing the safety and effectiveness of finerenone in patients with heart failure are currently ongoing. Esaxerenone provides antihypertensive effects and has been approved for the treatment of hypertension in Japan. Baxdrostat and lorundostat, novel selective aldosterone-synthase inhibitors, are currently under investigation. In phase II trials, baxdrostat and lorundostat were safe and effective in lowering blood pressure in resistant hypertension. In this review, we summarize and critically discuss the evidence for new drugs mitigating aldosterone in heart failure, hypertension, and chronic kidney disease.
Social selection analysis reveals limited effect of neighbors’ traits in Tree swallows
Authors: Labonté-Dupras Marie-Ève , Houle Carolyne , Pelletier Fanie , Garant Dany 
Published: July 2024

Abstract
Social interactions are ubiquitous in nature and can shape the fitness of individuals through social selection. This type of selection arises when phenotypes of neighbors influence the fitness of a focal individual. Quantifying social selection is crucial to better characterize the overall selective landscape. For example, if intraspecific competition is strong, traits that are beneficial for an individual could be detrimental to competitors. In this study, we quantified social selection acting on three key ecological traits (body mass, wing length, and laying date) in wild Tree swallow (Tachycineta bicolor) females. We used reproductive success measured at three stages throughout the breeding season as fitness proxies to assess selection acting at those decisive moments. We also quantified the effects of environment on selection using measures of conspecifics’ density, type of agricultural landscape, and presence of interspecific competitors. Overall, we found no strong evidence of social selection on these traits in our study system, although there were marginally nonsignificant selection gradients suggesting the positive effect of larger neighbors. Environmental variables affected reproductive success but did not strongly affect social selection gradients. Our study calls for more social selection estimates to be reported across environments to better understand its importance in wild populations.
On the evolutionary origin of discrete phenotypic plasticity
Authors: Sakamoto Takahiro , Innan Hideki 
Published: July 2024

Abstract
Phenotypic plasticity provides an attractive strategy for adapting to various environments, but the evolutionary mechanism of the underlying genetic system is poorly understood. We use a simple gene regulatory network model to explore how a species acquires phenotypic plasticity, particularly focusing on discrete phenotypic plasticity, which has been difficult to explain by quantitative genetic models. Our approach employs a population genetic framework that integrates the developmental process, where each individual undergoes growth to develop its phenotype, which subsequently becomes subject to selection pressures. Our model considers two alternative types of environments, with the gene regulatory network including a sensor gene that turns on and off depending on the type of environment. With this assumption, we demonstrate that the system gradually adapts by acquiring the ability to produce two distinct optimum phenotypes under two types of environments without changing genotype, resulting in phenotypic plasticity. We find that the resulting plasticity is often discrete after a lengthy period of evolution. Our results suggest that gene regulatory networks have a notable capacity to flexibly produce various phenotypes in response to environmental changes. This study also shows that the evolutionary dynamics of phenotype may differ significantly between mechanistic-based developmental models and quantitative genetics models, suggesting the utility of incorporating gene regulatory networks into evolutionary models.
The politicization of diplomacy: a comparative study of ambassador appointments
Authors: Niklasson Birgitta , Jezierska Katarzyna 
Published: July 2024

Abstract
A politicization of diplomacy weakens the professionalism of the foreign service and arguably endangers the external relations of states. Yet, this phenomenon has largely escaped scholarly scrutiny. Public administration research on politicization usually overlooks the foreign service, whereas diplomacy scholars have focused almost exclusively on the United States. Our exploratory study of ambassador appointments compares the levels and modes of politicization (through politically connected professionals, or political appointees) of 669 ambassadors in 2019, across seven countries and three administrative traditions. The analysis is guided by three expectations: 1) countries that are more politicized overall appoint more non-career ambassadors; 2) patronage recruitment of political appointees focuses on low-hardship postings; and 3) politically connected professionals are used to control politically important foreign missions. We find that states politicize their foreign services to a varied degree and in different ways. Appointing politically connected professionals instead of political appointees is the most common way of politicization among our cases. In this regard, the US is an outlier, which also points to the need of studying politicization of diplomacy comparatively. This article thus makes an important contribution by setting the agenda for future research on this hitherto underexplored topic.
The rise of Mali's ‘videomen’ as cybercombatants in global crisis ecologies
Authors: Cold-Ravnkilde Signe Marie , Sylla Almamy 
Published: July 2024

Abstract
This article examines the geopolitical shifts in Mali following its rejection of western intervention and subsequent partnerships with Russia. Mali is used as a case-study to explore the role of digital connectivity within global crisis ecologies. It challenges the narrative attributing Mali's coup solely to external influences, emphasizing the agency of local actors and new digital practices. Focusing on the role of ‘videomen’ in disseminating the narratives of Yèrèwolo, Mali's foremost anti-French and pro-Russian political movement, it examines how these actors shape public perceptions of Mali's new military leaders and their international partners. Using an assemblage framework to analyse smartphones' affordances, the nuanced dynamics shaping political legitimacy are elucidated, emphasizing the performative nature of authority in the digital age. Drawing on ethnographic fieldwork and quantitative analysis of online content, the article highlights how smartphones empower users like videomen to influence political dynamics amid crisis and geopolitical tensions. By reconstructing past events and reclaiming patriotism, videomen strategically use the political transition to outcompete traditional media professionals. The study underscores the need for understanding how localized dynamics shape broader political developments and international relations, offering insights into similar trends in other west African nations facing military coups and increased Russian involvement.
The Russian factor: emotions, narratives and reshaping China's norms in international conflicts
Authors: Lu Xiaoyu , Zhang Tinghao 
Published: July 2024

Abstract
How did Russia, despite being in a weaker position, exercise a continuous and resilient influence on China's normative approach to international conflicts from Syria to Ukraine? This article proposes a theoretical framework that connects the affective turn and norm studies in International Relations. It conceptualizes emotions as the affective infrastructure of norm scripts: shared political feelings create resonance, based on which persuasive narratives work to maintain solidarity and institutionalize normative changes. Drawing on primary Russian and Chinese resources and using process tracing to identify critical junctures in the partnership and institutional channels for Russian campaigns, this article demonstrates how China's alignment with Russia is not solely based on geopolitical interests or constructed identities but rather a result of feelings of isolation and marginalization that firstly resonated with and then exploited by Russian actors. Furthermore, this article identifies three types of persuasive narratives used to construct continuity, analogy and identification in consolidating emotional resonance around the threat of a homogenous West and inducing normative convergence. This drives China to adopt policies in conflict with national interests and norms on sovereignty and territorial integrity that trigger a reflective assessment of the Russian influence, while underlining the growing importance of emotion diplomacy.
Xerox soldiers, YouTube commanders and Twitter brigades: information warfare in eastern Congo
Authors: Vogel Christoph N , Musamba Josaphat 
Published: July 2024

Abstract
Researching contemporary warfare requires attention to digital connectivity in contexts of crisis and conflict. This article traces the evolution of information warfare with a focus on the digitization, democratization and polarization of conflict-related communication and discourse. We argue that information warfare amplifies with the advent of social media—multiplying the scales for the conduct of hostilities, reducing distance and duration, and democratizing participation—notably in Africa, a continent often considered a trailblazer of digital innovation. Orthodox scholarship, however, tends to focus disproportionately on cases relevant to the global North. Examples include the global ‘war on terror’ or the Russian war against Ukraine. Investigating protracted violent conflict in the global South instead, our analysis fills an important gap in this literature. Through the prism of the African Great Lakes region, the world's deadliest contemporary war zone, we leverage a counterintuitive perspective of a conflict considered backwards in mainstream analysis. Drawing from long-term field research and digital ethnography, we propose the notion of ‘reciprocal warscapes’, where not only do battlefield events influence the underlying politics of conflict but where, reciprocally, digital warfare increasingly shapes the conduct of war itself.
Let’s Talk About Sex: Instructor Views and Hesitancies Related to Sex and Gender in the Biology Classroom
Authors: Lewis A Kelsey , Josefson Chloe C , Orr Teri J , Harris Breanna N 
Published: July 2024

Synopsis
There is much current debate in the United States regarding how sex and gender are approached in science and medical classrooms. There does not seem to be sufficient consensus around why it must be taught and how it should be implemented. State-enacted restrictions to both education and healthcare in recent years demonstrate the relevance and importance of sex and gender in the college classroom, not only including but especially in the biology classroom. Given the areas comprising the Society for Integrative and Comparative Biology (SICB), these topics of sex and gender in biology instruction are incredibly salient to our members. Thus, this survey aimed to determine instructors’ views of and experiences with sex-diverse gender-inclusive biology. College-level biology instructors who are members of SICB were surveyed about their views of science, views of sex and gender, teaching philosophy, and their experiences with inclusive teaching and with sex-diverse gender-inclusive teaching. The resulting data lead us to implore academic biology to provide more sex-diverse and gender-inclusive teaching tools and resources to educators, while minimizing potential fear of retaliation and backlash to instructors who utilize these teaching methods.
Wax “Tails” Enable Planthopper Nymphs to Self-Right Midair and Land on Their Feet
Authors: McDonald Christina L , Alcalde Gerwin T , Jones Thomas C , Laude Ruby Ana P , Yap Sheryl A , Bhamla Saad 
Published: July 2024

Synopsis
The striking appearance of wax ‘tails’—posterior wax projections on planthopper nymphs—has captivated entomologists and naturalists alike. Despite their intriguing presence, the functional roles of these formations remain largely unexplored. This study leverages high-speed imaging to uncover the biomechanical implications of wax structures in the aerial dynamics of planthopper nymphs (Ricania sp.). We quantitatively demonstrate that removing wax tails significantly increases body rotations during jumps. Specifically, nymphs without wax undergo continuous rotations, averaging 4.2 ± 1.8 per jump, in contrast to wax-intact nymphs, who do not complete a full rotation, averaging only 0.7 ± 0.2 per jump. This along with significant reductions in angular and translational velocity from takeoff to landing suggest that aerodynamic drag forces on wax structures effectively counteract rotation. These stark differences in body rotation correlate with landing success: Nymphs with wax intact achieve a near perfect landing rate of 98.5%, while those without wax manage only a 35.5% success rate. Jump trajectory analysis reveals that wax-intact jumps transition from parabolic to asymmetric shapes at higher takeoff velocities and show a significantly greater reduction in velocity from takeoff to landing compared to wax-removed jumps, demonstrating how wax structures help nymphs achieve more stable and controlled descents. Our findings confirm the aerodynamic self-righting functionality of wax tails in stabilizing planthopper nymph landings, advancing our understanding of the complex relationship between wax morphology and aerial maneuverability, with broader implications for wingless insect aerial adaptations and bioinspired robotics.
Developing-Country Representation and Public Attitudes toward International Organizations: The Case of IMF Governance Reform
Authors: McDowell Daniel , Steinberg David , Aytaç S Erdem , Gueorguiev Dimitar 
Published: July 2024

Abstract
Several prominent international organizations (IOs) maintain decision-making structures that under-represent developing countries. This paper argues that individuals in developing countries are more supportive of engaging with IOs that give a greater voice to fellow developing countries. We posit that the balance of decision-making power influences support for IOs by improving perceptions of both input legitimacy and output legitimacy. Empirically, we focus on the International Monetary Fund (IMF) and draw on original survey experiments in four developing countries: Argentina, China, South Africa, and Turkey. Results reveal that increased representation of developing countries increases public support for IMF participation. We also find consistent evidence that this effect works through an input legitimacy mechanism, specifically by improving perceptions of procedural fairness. These findings suggest that public support for IOs is affected by the balance of decision-making power within these organizations.
Caregivers and Clinic Providers View Soft Casts for Pediatric Hand Burns as Acceptable and Feasible: A Mixed Methods Survey
Authors: Schuh Jennifer M , Linzell Leanna L , Abebrese Emmanuel L , Flynn-O’Brien Katherine T 
Published: July 2024

Abstract
Soft casts have been introduced as an efficacious strategy to manage hand burns that simplifies wound care for families. We hypothesized that the outpatient use of soft casts in pediatric hand burns would be viewed as acceptable by patient caregivers and providers, logistically feasible, and result in satisfactory clinical outcomes. A review was performed of pediatric clinic patients managed with soft casts since implementation (9/2022-9/2023). Patient caregivers and providers were surveyed. The primary outcome was the acceptability of soft casts as a management strategy (questions targeted care burden, overall satisfaction, comfort, pragmatism, and healing concerns). The secondary outcome was feasibility (effect on clinic workflow, and efficiency). Survey responses were collected from 70% of caregivers and 95% of providers. Responses overwhelmingly favored soft cast acceptability. Among providers, 84% agreed that “the soft cast method simplified the hand burn care experience in our clinic” and 100% indicated “the soft cast was easy for parents to manage at home” (Likert range 7-10, mode 10). Thirty-three English-speaking patients with partial and full-thickness hand burns were managed with soft casts. A mean of 1.8 reapplications (mode 1, range 1-5) was required with a median healing time of 13 days. No infections were attributed to the use of soft casting, and only 1 patient ultimately required grafting. Overall, the introduction of soft casts as a management strategy for pediatric hand burns was acceptable and feasible. The clinical outcomes assessed suggest soft casts are associated with good wound healing with minimal wound care responsibilities for patients and families.
A new genus and species of mantis shrimp from Australia and Japan (Stomatopoda: Tetrasquillidae), with a revised diagnosis of Tetrasquillidae and a key to its genera
Authors: Ahyong Shane T , Nakajima Hiroki , Naruse Tohru 
Published: July 2024

Abstract
A new genus and species of lysiosquilloid mantis shrimp is described from Australia and Japan. It is unique in Stomatopoda by its unusual telson ornamentation in which the short intermediate and lateral primary teeth, accompanied by a row of short, graded serrations inward of the intermediate teeth, partially overhang a row of minute submarginal denticles. Although distinctive as a new genus and species, Incertasquilla chimeragen. et sp. nov. does not fit clearly into existing lysiosquilloid families as currently diagnosed and, in some respects, shares a mosaic of features present in several families. Incertasquilla chimeragen. et sp. nov., however, currently fits best into Tetrasquillidae, where it is tentatively placed, although further phylogenetic study may show it belongs in a separate family altogether. In the light of the new character combinations presented by the discovery of Incertasquilla chimeragen. et sp. nov., a revised diagnosis for Tetrasquillidae and updated key to the genera are provided. The discovery of Incertasquilla chimeragen. et sp. nov. expands the described lysiosquilloid fauna to 14 genera and 30 species in Australia, and 10 and 16 in Japan, respectively.
Continued decline in sublethal effects of Bt toxins on Helicoverpa zea (Lepidoptera: Noctuidae) in field corn
Authors: Bryant Tim B , Greene Jeremy K , Reisig Dominic , Reay-Jones Francis P F 
Published: July 2024

Abstract
The majority of field corn, Zea mays L., in the southeastern United States has been genetically engineered to express insecticidal toxins produced by the soil bacterium, Bacillus thuringiensis (Bt). Field corn is the most important mid-season host for corn earworm, Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae), which has developed resistance to all Cry toxins in Bt corn. From 2020 to 2023, corn earworm pupae were collected from early- and late-planted pyramided hybrids expressing Bt toxins and non-Bt near-isolines in North and South Carolina (16 trials). A total of 5,856 pupae were collected across all trials, with 55 and 88% more pupae collected in later-planted trials relative to early plantings in North and South Carolina, respectively. Only 20 pupae were collected from hybrids expressing Cry1F + Cry1Ab + Vip3A20 across all trials. Averaged across trials, Cry1A.105 + Cry2Ab2 hybrids reduced pupal weight by 6 and 9% in North and South Carolina, respectively, relative to the non-Bt near-isoline. Cry1F + Cry1Ab hybrids reduced pupal weight on average by 3 and 8% in North and South Carolina, respectively, relative to the non-Bt near-isoline. The impact of the Bt toxins on pupal weight varied among trials. When combined with data from 2014 to 2019 from previous studies, a significant decline in the percent reduction in pupal weight over time was found in both states and hybrid families. This study demonstrates a continued decline in the sublethal impacts of Bt toxins on corn earworm, emphasizing the importance of insect resistance management practices.
Major merger fraction along the massive galaxy-quenching channel at 0.2 &lt; z &lt; 0.7
Authors: Inoue Shin , Ohta Kouji , Asada Yoshihisa , Sawicki Marcin , Desprez Guillaume , Gwyn Stephen , Picouet Vincent 
Published: July 2024

Abstract
We study the major merger fraction along the massive galaxy-quenching channel (traced with rest-frame $\mathrm{NUV}-r$ color) at z = 0.2–0.7, aiming to examine the cosmic web detachment (CWD) scenario of galaxy quenching. In this scenario, the major merger fraction is expected to be high in green-valley galaxies as compared with those in star-forming and quiescent galaxies of similar stellar mass. We used photometry in the E-COSMOS field to select 1491 (2334) massive ($M_\ast \\gt 10^{9.5}\, M_{\odot }$) galaxies with $m_i\\lt 22$ mag ($m_z\\lt 22$ mag) at z = 0.2–0.4 (z = 0.4–0.7) in the rest-frame color range of $0.8\\lt r-K_{\rm s}\\lt 1.3$. We define a major galaxy–galaxy merger as a galaxy pair of comparable angular size and luminosity with tidal tails or bridges, and we identified such major mergers through visual inspection of Subaru HSC-SSP PDR 2 i- and z-band images. We classify 92 (123) galaxies as major merger galaxies at z = 0.2–0.4 (z = 0.4–0.7). The resulting major merger fraction is 5%–6% and this fraction does not change with galaxy color along the massive galaxy-quenching channel. The result is not consistent with the expectation based of the CWD scenario as the dominant mechanism of massive galaxy quenching. However, there are some caveats such as (i) the mergers that cause quenching may lose their visible merger signatures rapidly before they enter the green valley, (ii) our method may not trace the cosmic web sufficiently well, and (iii) because of our mass limit, most of the galaxies in our sample may have already experienced CWD events at higher redshifts than those studied here. Further studies with deeper data are desirable in the future.