bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of depression and anxiety symptom trajectories between women who had an abortion and women denied one
Authors: Foster D. G. , Steinberg J. R. , Roberts S. C. M. , Neuhaus J. , Biggs M. A. 
Published: January 2015

BackgroundThis study prospectively assesses the mental health outcomes among women seeking abortions, by comparing women having later abortions with women denied abortions, up to 2 years post-abortion seeking.MethodWe present the first 2 years of a 5-year telephone interview study that is following 956 women who sought an abortion from 30 facilities throughout the USA. We use adjusted linear mixed-effects regression analyses to assess whether symptoms of depression and anxiety, as measured by the Brief Symptom Inventory-short form and the Primary Care Evaluation of Mental Disorders Patient Health Questionnaire, differ over time among women denied an abortion due to advanced gestational age, compared with women who received abortions.ResultsBaseline predicted mean depressive symptom scores for women denied abortion (3.07) were similar to women receiving an abortion just below the gestational limit (2.86). Depressive symptoms declined over time, with no difference between groups. Initial predicted mean anxiety symptoms were higher among women denied care (2.59) than among women who had an abortion just below the gestational limit (1.91). Anxiety levels in the two groups declined and converged after 1 year.ConclusionsWomen who received an abortion had similar or lower levels of depression and anxiety than women denied an abortion. Our findings do not support the notion that abortion is a cause of mental health problems.
Luther's necessitarian argument inDe servo arbitrio
Authors: KRAAL ANDERS 
Published: January 2015

AbstractInDe servo arbitrio(1525) Luther famously argues that the divine attributes of will, power, foreknowledge, and immutability are incompatible with (human) free will, and hence that free will is a ‘name with no reality’. I survey some earlier explications of Luther's argument in the literature, and reject them as exegetically unsound. I then go on to propose a new explication. On the proposed explication, Luther's argument turns out to be theologically cogent, provided that we follow Luther in understanding the relevant divine attributes in accordance with Augustinian theology.
Public perception and characteristics related to acceptance of the sugar-sweetened beverage taxation launched in France in 2012
Authors: Julia Chantal , Méjean Caroline , Vicari Florence , Péneau Sandrine , Hercberg Serge 
Published: January 2015

AbstractObjectiveIn France, an excise tax on sugar-sweetened beverages was introduced on 1 January 2012. Our objective was to assess perception of this tax as well as the sociodemographic characteristics of its supporters and opponents.DesignCross-sectional study within the Nutrinet-Santé cohort. A sub-sample of 1996 individuals was selected among participants in the Nutrinet-Santé cohort study. Perceptions of the sugar-sweetened beverage tax were assessed via self-administered questionnaires. The sociodemographic and dietary profiles of supporters and opponents of this tax were explored by multinomial logistic regression.SettingNationally representative French sample, 2012.SubjectsAdults aged >18 years (largest sample n 1996).ResultsHalf of the study sample was generally supportive of the tax and 57·7 % perceived it as helpful in improving population health. Participants were more likely to support the tax model if the revenue it generated would be used for health-care system improvement (72·7 %) and if such taxing was associated with a corresponding decrease in the prices of other foodstuffs (71·5 %). Older participants were more likely to support the tax than were their younger counterparts (OR=2·37; 95 % CI 1·60, 3·49 for >65 years v. 26–45 years; P<0·001). Participants with lower educational levels were less likely to support the tax than were those with more formal education (OR=0·31; 95 % CI 0·19, 0·52 for low educational level v. high education level; P<0·001). In our models, sugar-sweetened beverage consumption was not associated with tax perception.ConclusionsThe French sugar-sweetened beverage tax appeared to be favourably perceived by the public. Sociodemographic factors modulated such perceptions and should thus be taken into consideration when drafting future public health measures.
The Spaces of Dream: Lutosławski's Modernist Heterotopias
Authors: REYLAND NICHOLAS 
Published: January 2015

AbstractThis article offers a revisionist perspective on the contested notion of Witold Lutosławski's authenticity as a modernist composer. In doing so, it seeks to contribute to musicology's increasingly nuanced narration of the story of musical modernism. The case is argued partly by relating Lutosławski's output to broader traditions in twentieth-century modernism, including musical representations of alienation, loss, violence, and nostalgia. Crucially, however, it is also argued by interpreting the more conventionally gratifying aspects of his pieces as something other than a hedonistic cop out. Adapting ideas from Michel Foucault, such passages are deemedheterotopianin function and interpreted in a wider-ranging sociohistorical context including Poland's responses to modernism and to Soviet Cold War oppression. The article's other main objective, therefore, is to interpret as heterotopian (and thus alternatively authentic) the expressive, structural and symbolic functions of passages in Lutosławski's works, thereby introducing Foucault's little-known idea to a wider audience of music scholars – given the concept's potential to contribute to critical explorations of a much wider diversity of musical texts and phenomena. Analysis of Lutosławski'sLes espaces du sommeilfor baritone and orchestra (1975) interconnects these strands.
Acoustics of the Everyday: Between Growth and Conflict in 1960s Japan
Authors: KANEDA MIKI 
Published: January 2015

AbstractFocusing on a multimedia practice labelled ‘intermedia art’, this article shows how experimental musical practices complicate popular characterizations of the idea of politics in 1960s Japan that are polarized by their focus on extraordinary economic growth, on the one hand, and radical protest, on the other. Like their counterparts in art, experimental musicians and artists such as Shiomi Mieko, Kosugi Takehisa, and Yuasa Jōji took an interest in everyday sounds, spaces, and technologies as sites for artistic exploration. However, their musical approaches did not share the overtly political engagement with the scenes of protest playing out in the public sphere that played a central role in the visual arts. Through an investigation of the notion of ambiguity in the acoustics of intermedia, the article seeks to re-examine understandings about the role of sound in shifting perceptions about political participation.
Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR–eIF4F pathway
Authors: Susor Andrej , Jansova Denisa , Cerna Renata , Danylevska Anna , Anger Martin , Toralova Tereza , Malik Radek , Supolikova Jaroslava , Cook Matthew S. , Oh Jeong Su , Kubelka Michal 
Published: January 2015

AbstractThe fully grown mammalian oocyte is transcriptionally quiescent and utilizes only transcripts synthesized and stored during early development. However, we find that an abundant RNA population is retained in the oocyte nucleus and contains specific mRNAs important for meiotic progression. Here we show that during the first meiotic division, shortly after nuclear envelope breakdown, translational hotspots develop in the chromosomal area and in a region that was previously surrounded the nucleus. These distinct translational hotspots are separated by endoplasmic reticulum and Lamin, and disappear following polar body extrusion. Chromosomal translational hotspots are controlled by the activity of the mTOR–eIF4F pathway. Here we reveal a mechanism that—following the resumption of meiosis—controls the temporal and spatial translation of a specific set of transcripts required for normal spindle assembly, chromosome alignment and segregation.
Concurrent radiotherapy and weekly chemotherapy of 5-fluorouracil and platinum agents for postoperative locoregional recurrence of oesophageal squamous cell carcinoma
Authors: Zhang Wen-Wen , Zhu Yu-Jia , Yang Han , Wang Qiao-Xuan , Wang Xiao-Hui , Xiao Wei-Wei , Li Qiao-Qiao , Liu Meng-Zhong , Hu Yong-Hong 
Published: January 2015

AbstractThe most optimal management for postoperative locoregional recurrence of oesophageal squamous cell carcinoma is still controversial. Several studies have reported the feasibility and efficacy of concurrent chemoradiotherapy (CCRT), mostly with three-weekly or four-weekly schedule of chemotherapy. However, treatment compliance was not quite satisfactory, probably due to treatment-related toxicities. Since CCRT with weekly chemotherapy regimens have demonstrated a favorable toxicity profile as well as promising survival in certain types of cancer, we aimed to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly chemotherapy with 5-fluorouracil (5-FU) and platinum agents for patients with postoperative locoregional recurrence of oesophageal squamous cell carcinoma in our center. Twenty-seven consecutive patients who were diagnosed with postoperative locoregional recurrence of oesophageal squamous cell carcinoma and received CCRT with weekly chemotherapy of 5-FU and platinum agents were retrospectively analyzed. Our data showed that the present protocol of radiotherapy combined concurrently with weekly chemotherapy of 5-FU and platinum agents was a safe and effective salvage treatment for postoperative locoregional recurrence of oesophageal squamous cell carcinoma.
Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity
Authors: Liang Rui , Shen Xiao Li , Zhang Boyang , Li Yuzhe , Xu Wentao , Zhao Changhui , Luo YunBo , Huang Kunlun 
Published: January 2015

AbstractOxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK, MAP3K) family member that plays an important role in oxidative stress-induced cell apoptosis. In this study, we performed RNA interference of ASK1 in HEK293 cells and employed an iTRAQ-based quantitative proteomics approach to globally investigate the regulatory mechanism of ASK1 in OTA-induced renal cytotoxicity. Our results showed that ASK1 knockdown alleviated OTA-induced ROS generation and Δψm loss and thus desensitized the cells to OTA-induced apoptosis. We identified 33 and 24 differentially expressed proteins upon OTA treatment in scrambled and ASK1 knockdown cells, respectively. Pathway classification and analysis revealed that ASK1 participated in OTA-induced inhibition of mRNA splicing, nucleotide metabolism, the cell cycle, DNA repair and the activation of lipid metabolism. We concluded that ASK1 plays an essential role in promoting OTA-induced renal cytotoxicity.
The relevance of nanoscale biological fragments for ice nucleation in clouds
Authors: O′Sullivan D. , Murray B. J. , Ross J. F. , Whale T. F. , Price H. C. , Atkinson J. D. , Umo N. S. , Webb M. E. 
Published: January 2015

AbstractMost studies of the role of biological entities as atmospheric ice-nucleating particles have focused on relatively rare supermicron particles such as bacterial cells, fungal spores and pollen grains. However, it is not clear that there are sufficient numbers of these particles in the atmosphere to strongly influence clouds. Here we show that the ice-nucleating activity of a fungus from the ubiquitous genusFusariumis related to the presence of nanometre-scale particles which are far more numerous and therefore potentially far more important for cloud glaciation than whole intact spores or hyphae. In addition, we quantify the ice-nucleating activity of nano-ice nucleating particles (nano-INPs) washed off pollen and also show that nano-INPs are present in a soil sample. Based on these results, we suggest that there is a reservoir of biological nano-INPs present in the environment which may, for example, become aerosolised in association with fertile soil dust particles.
MiR-148b suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting WNT1/β-catenin pathway
Authors: Zhang Jun-gang , Shi Ying , Hong De-fei , Song Mengqi , Huang Dongsheng , Wang Chun-you , Zhao Gang 
Published: January 2015

AbstractAccumulating evidences indicate that microRNAs play a vital role in regulating tumor progression. However, the roles of miR-148b in hepatocellular carcinoma (HCC) are still largely unknown. In this study, our data showed that miR-148b was significantly downregulated in 40 pairs of human HCC tissues. Further, the deregulated miR-148b was significantly correlated with larger tumor size, more tumor number, metastasis and worse prognosis in HCC. Overexpression of miR-148b inhibited HCC HepG2 cells proliferation and tumorigenicity. Further, miR-148b induced cells apoptosis by activating caspase- 3 and caspase-9 and induced S phase arrest by regulating cyclinD1 and p21 and also inhibited cell invasion. Data from the dual-luciferase reporter gene assay showed that WNT1 was a direct target of miR-148b and overexpressed WNT1 inversely correlated with miR-148b levels in HCC tissues. Silencing of WNT1 inhibited the growth of HCC cells and also induced cells apoptosis and inhibited invasion, which is consistent with the effects of miR-148b overexpression. MiR-148b downregulated expression of WNT1, β-catenin and C-myc, while upregulated E-cadherin expression. We conclude that the frequently downregulated miR-148b can regulate WNT1/β-catenin signalling pathway and function as a tumor suppressor in HCC. These findings suggest that miR-148b may serve as a novel therapeutic target for HCC.
Individual Sensitivity to Spectral and Temporal Cues in Listeners With Hearing Impairment
Authors: Souza Pamela E. , Wright Richard A. , Blackburn Michael C. , Tatman Rachael , Gallun Frederick J. 
Published: January 2015

Purpose
The present study was designed to evaluate use of spectral and temporal cues under conditions in which both types of cues were available.

Method
Participants included adults with normal hearing and hearing loss. We focused on 3 categories of speech cues: static spectral (spectral shape), dynamic spectral (formant change), and temporal (amplitude envelope). Spectral and/or temporal dimensions of synthetic speech were systematically manipulated along a continuum, and recognition was measured using the manipulated stimuli. Level was controlled to ensure cue audibility. Discriminant function analysis was used to determine to what degree spectral and temporal information contributed to the identification of each stimulus.

Results
Listeners with normal hearing were influenced to a greater extent by spectral cues for all stimuli. Listeners with hearing impairment generally utilized spectral cues when the information was static (spectral shape) but used temporal cues when the information was dynamic (formant transition). The relative use of spectral and temporal dimensions varied among individuals, especially among listeners with hearing loss.

Conclusion
Information about spectral and temporal cue use may aid in identifying listeners who rely to a greater extent on particular acoustic cues and applying that information toward therapeutic interventions.
Face-Referenced Measurement of Perioral Stiffness and Speech Kinematics in Parkinson's Disease
Authors: Chu Shin Ying , Barlow Steven M. , Lee Jaehoon 
Published: January 2015

Purpose
Perioral biomechanics, labial kinematics, and associated electromyographic signals were sampled and characterized in individuals with Parkinson's disease (PD) as a function of medication state.

Method
Passive perioral stiffness was sampled using the OroSTIFF system in 10 individuals with PD in a medication ON and a medication OFF state and compared to 10 matched controls. Perioral stiffness, derived as the quotient of resultant force and interoral angle span, was modeled with regression techniques. Labial movement amplitudes and integrated electromyograms from select lip muscles were evaluated during syllable production using a 4-D computerized motion capture system.

Results
Multilevel regression modeling showed greater perioral stiffness in patients with PD, consistent with the clinical correlate of rigidity. In the medication-OFF state, individuals with PD manifested greater integrated electromyogram levels for the orbicularis oris inferior compared to controls, which increased further after consumption of levodopa.

Conclusions
This study illustrates the application of biomechanical, electrophysiological, and kinematic methods to better understand the pathophysiology of speech motor control in PD.
Status and Conservation of Interior Redband Trout in the Western United States
Authors: Muhlfeld Clint C. , Albeke Shannon E. , Gunckel Stephanie L. , Writer Benjamin J. , Shepard Bradley B. , May Bruce E. 
Published: January 2015

Abstract
In this article we describe the current status and conservation of interior (potamodromous) Redband Trout Oncorhynchus mykiss sspp. throughout its range in the western United States using extant data and expert opinion provided by fish managers. Redband Trout historically occupied 60,295 km of stream habitat and 152 natural lakes. Currently, Redband Trout occupy 25,417 km of stream habitat (42% of their historical range) and 124 lakes or reservoirs. Nonhybridized populations are assumed to occupy 11,695 km (46%) of currently occupied streams; however, fish from only 4,473 km (18%) have been genetically tested. Approximately 47% of the streams occupied by Redband Trout occur on private land, 45% on government lands, and 8% in protected areas. A total of 210 Redband Trout populations, occupying 15,252 km of stream habitat (60% of the current distribution) and 95,158 ha of lake habitat (52%), are being managed as “conservation populations.” Most conservation populations have been designated as weakly to strongly connected metapopulations (125; 60%) and occupy much more stream length (14,112 km; 93%) than isolated conservation populations (1,141 km; 7%). The primary threats to Redband Trout include invasive species, habitat degradation and fragmentation, and climate change. Although the historical distribution of interior Redband Trout has declined dramatically, we conclude that the species is not currently at imminent risk of extinction because it is still widely distributed with many populations isolated by physical barriers and active conservation efforts are occurring for many populations. However, the hybridization status of many populations has not been well quantified, and introgression may be more prevalent than documented here. We recommend (1) collecting additional genetic data and estimating distribution and abundance by means of a more rigorous spatial sampling design to reduce uncertainties, (2) collecting additional information to assess and predict the impacts of climate on populations, and (3) continuing to use this database to evaluate the status of Redband Trout and inform conservation efforts through time.
Received March 21, 2014; accepted August 1, 2014
A moonlighting metabolic protein influences repair at DNA double-stranded breaks
Authors: Torres-Machorro Ana Lilia , Aris John P. , Pillus Lorraine 
Published: January 2015

Abstract
Catalytically active proteins with divergent dual functions are often described as ‘moonlighting’. In this work we characterize a new, chromatin-based function of Lys20, a moonlighting protein that is well known for its role in metabolism. Lys20 was initially described as homocitrate synthase (HCS), the first enzyme in the lysine biosynthetic pathway in yeast. Its nuclear localization led to the discovery of a key role for Lys20 in DNA damage repair through its interaction with the MYST family histone acetyltransferase Esa1. Overexpression of Lys20 promotes suppression of DNA damage sensitivity of esa1 mutants. In this work, by taking advantage of LYS20 mutants that are active in repair but not in lysine biosynthesis, the mechanism of suppression of esa1 was characterized. First we analyzed the chromatin landscape of esa1 cells, finding impaired histone acetylation and eviction. Lys20 was recruited to sites of DNA damage, and its overexpression promoted enhanced recruitment of the INO80 remodeling complex to restore normal histone eviction at the damage sites. This study improves understanding of the evolutionary, structural and biological relevance of independent activities in a moonlighting protein and links metabolism to DNA damage repair.
The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ
Authors: Hirota Kouji , Yoshikiyo Kazunori , Guilbaud Guillaume , Tsurimoto Toshiki , Murai Junko , Tsuda Masataka , Phillips Lara G. , Narita Takeo , Nishihara Kana , Kobayashi Kaori , Yamada Kouich , Nakamura Jun , Pommier Yves , Lehmann Alan , Sale Julian E. , Takeda Shunichi 
Published: January 2015

Abstract
The replicative DNA polymerase Polδ consists of a catalytic subunit POLD1/p125 and three regulatory subunits POLD2/p50, POLD3/p66 and POLD4/p12. The ortholog of POLD3 in Saccharomyces cerevisiae, Pol32, is required for a significant proportion of spontaneous and UV-induced mutagenesis through its additional role in translesion synthesis (TLS) as a subunit of DNA polymerase ζ. Remarkably, chicken DT40 B lymphocytes deficient in POLD3 are viable and able to replicate undamaged genomic DNA with normal kinetics. Like its counterpart in yeast, POLD3 is required for fully effective TLS, its loss resulting in hypersensitivity to a variety of DNA damaging agents, a diminished ability to maintain replication fork progression after UV irradiation and a significant decrease in abasic site-induced mutagenesis in the immunoglobulin loci. However, these defects appear to be largely independent of Polζ, suggesting that POLD3 makes a significant contribution to TLS independently of Polζ in DT40 cells. Indeed, combining polη, polζ and pold3 mutations results in synthetic lethality. Additionally, we show in vitro that POLD3 promotes extension beyond an abasic by the Polδ holoenzyme suggesting that while POLD3 is not required for normal replication, it may help Polδ to complete abasic site bypass independently of canonical TLS polymerases.
A physiological significance of the functional interaction between Mus81 and Rad27 in homologous recombination repair
Authors: Thu Huong Phung Thi , Nguyen Tuan Anh , Munashingha Palinda Ruvan , Kwon Buki , Dao Van Quy , Seo Yeon-Soo 
Published: January 2015

Abstract
Fen1 and Mus81–Mms4 are endonucleases involved in the processing of various DNA structural intermediates, and they were shown to have genetic and functional interactions with each other. Here, we show the in vivo significance of the interactions between Mus81 and Rad27 (yeast Fen1). The N-terminal 120 amino-acid (aa) region of Mus81, although entirely dispensable for its catalytic activity, was essential for the abilities of Mus81 to bind to and be stimulated by Rad27. In the absence of SGS1, the mus81Δ120N mutation lacking the N-terminal 120 aa region exhibited synthetic lethality, and the lethality was rescued by deletion of RAD52, a key homologous recombination mediator. These findings, together with the fact that Sgs1 constitutes a redundant pathway with Mus81–Mms4, indicate that the N-terminus-mediated interaction of Mus81 with Rad27 is physiologically important in resolving toxic recombination intermediates. Mutagenic analyses of the N-terminal region identified two distinct motifs, named N21–26 (aa from 21–26) and N108–114 (aa from 108–114) important for the in vitro and in vivo functions of Mus81. Our findings indicate that the N-terminal region of Mus81 acts as a landing pad to interact with Rad27 and that Mus81 and Rad27 work conjointly for efficient removal of various aberrant DNA structures.