bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Palladium Catalyzed Asymmetric Allylation of 3‐OBoc‐Oxindoles: An Efficient Synthesis of 3‐Allyl‐3‐hydroxyoxindoles.
Authors: Jayakumar Samydurai , Kumarswamyreddy Nandarapu , Prakash Muthuraj , Kesavan Venkitasamy 
Published: July 2015

AbstractA tartrate derived bi(oxazoline) ligand causes remarkable asymmetric induction in the Pd‐catalyzed allylation of protected oxindoles.
ChemInform Abstract: Tuning of Tetrathiafulvalene Properties: Versatile Synthesis of N‐Arylated Monopyrrolotetrathiafulvalenes via Ullmann‐Type Coupling Reactions.
Authors: Azov Vladimir A , Janott Diana , Schlueter Dirk , Zeller Matthias 
Published: July 2015

AbstractN‐Arylation of pyrrolotetrathiafulvalenes by aryl halides gives the corresponding Ullmann‐type products, which were studied by UV spectroscopy, electrochemistry, and crystallography.
ChemInform Abstract: Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Arylation of β‐Pyrazol‐1‐yl Acrylates.
Authors: Gopula Balraj , Tsai Yun‐Fan , Kuo Ting‐Shen , Wu Ping‐Yu , Henschke Julian P. , Wu Hsyueh‐Liang 
Published: July 2015

AbstractThe reaction proceeds with high regio‐ and enantioselectivity and can be applied in the formal synthesis of the bioactive compound (XIII), an agonist toward the human GPR40 G‐protein‐coupled receptor.
ChemInform Abstract: Metal‐Free Synthesis of 3,5‐Disubstituted 1H‐ and 1‐Aryl‐1H‐pyrazoles from 1,3‐Diyne‐indole Derivatives Employing Two Successive Hydroaminations.
Authors: Bassaco Mariana M. , Fortes Margiani P. , Kaufman Teodoro S. , Silveira Claudio C. 
Published: July 2015

AbstractUnder optimized and mild reaction conditions, symmetric and non‐symmetric 1,3‐diyne‐indole derivatives react with hydrazine and a variety of arylhydrazines.
ChemInform Abstract: Efficient Domino Synthesis of Benzimidazole Derivatives: Copper Catalysis versus Transition Metal‐Free Conditions.
Authors: Liu Haiquan , Tang Jiaming , Jiang Liu , Zheng Tingting , Wang Xiaoxia , Lv Xin 
Published: July 2015

AbstractDomino reactions of o‐haloaryl carbodiimides with active methylene compounds allow the synthesis of a wide variety of 2‐alkyl and 2‐alkenyl benzimidazole derivatives.
ChemInform Abstract: A Novel Three‐Component Reaction Involving Terminal Alkynes, Elemental Sulfur, and Strained Heterocycles.
Authors: Samzadeh‐Kermani Alireza 
Published: July 2015

Abstractas a facile route for the synthesis of functionalized 1,3‐oxathiolanes (III) and 1,3‐thiazolidines (V)
ChemInform Abstract: SiO2—H3BO3 Promoted Solvent‐Free, Green and Sustainable Synthesis of Bioactive 1‐Substituted‐1H‐tetrazole Analogues.
Authors: Parveen Mehtab , Ahmad Faheem , Mohammed Malla Ali , Azaz Shaista 
Published: July 2015

AbstractMulti‐functionalized title compounds (III) are synthesized by condensation of various heterocyclic/aromatic primary amines (I), sodium azide, and triethyl orthoformate (II) without use of an environmentally toxic solvent.
ChemInform Abstract: Discovery of Antibiotic (E)‐3‐(3‐Carboxyphenyl)‐2‐(4‐cyanostyryl)quinazolin‐4(3H)‐one.
Authors: Chang Mayland , et al.  
Published: July 2015

AbstractA library of quinazolinones is prepared with a view to developing novel classes of antibiotics.
ChemInform Abstract: An Efficient Approach to gem‐Difluorocyclopropylstannanes via Highly Regio‐ and Stereoselective Hydrostannylation of gem‐Difluorocyclopropenes and Their Unique Ring‐Opening Reaction to Afford β‐Fluoroallylic Alcohols.
Authors: Nihei T. , Hoshino T. , Konno T. 
Published: July 2015

AbstractCompound (VIg) undergoes ring‐opening reactions with water, alcohols, carboxylic acids and amides as nucleophiles.
ChemInform Abstract: Chemical Synthesis of the Tumor‐Associated Globo H Antigen.
Authors: Mandal Satadru S. , Liao Guochao , Guo Zhongwu 
Published: July 2015

AbstractA derivative of the tumor‐associated globo H antigen, a complex hexasaccharide, is synthesized by convergent and efficient [3+2+1] strategy using various glycosylation methods.
ChemInform Abstract: New Duclauxamide from Penicillium manginii YIM PH30375 and Structure Revision of the Duclauxin Family.
Authors: Cao Pei , Yang Jing , Miao Cui‐Ping , Yan Yijun , Ma Ya‐Tuan , Li Xiao‐Nian , Zhao Li‐Xing , Huang Sheng‐Xiong 
Published: July 2015

AbstractThe structural eludication of the title compound (I) confirms the C‐9′ configuration to be (S) and therefore also revises the structures of other duclauxin analogues.
ChemInform Abstract: Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile.
Authors: Liao Yang , Liu Xia , Yang Jing , Lao Yuan‐Zhi , Yang Xing‐Wei , Li Xiao‐Nian , Zhang Jing‐Jing , Ding Zhi‐jie , Xu Hong‐Xi , Xu Gang 
Published: July 2015

AbstractHypersubones A (II) and B (II) are tested on their cytotoxicity against 4 human cancer cell lines: the HepG2 human hepatocarcinoma cell line, the Eca109 esophageal carcinoma cell line, the HeLa cervical cancer cell line and the A549 non‐small cell lung cancer cell line.
ChemInform Abstract: Synthesis of Green Fuels from Biogenic Waste Through Thermochemical Route — The Role of Heterogeneous Catalyst: A Review
Authors: Mohanty Pravakar , Pant Kamal K. , Naik Satya Narayan , Parikh Jigisha , Hornung Andreas , Sahu J. N. 
Published: July 2015

AbstractReview: 159 refs.
Effects of personality on the opioidergic modulation of the emotion warmth‐liking
Authors: Burgdorf Christin , Rinn Constanze , Stemmler Gerhard 
Published: July 2015

AbstractNeurobiological research suggests there are discrete emotion systems, which are based on separate neural pathways with specific neurotransmitters (i.e., oxytocin, opioids). So far, autonomic regulation patterns of different positive emotions could not be unambiguously characterized. Warmth‐liking, as an emotion system, is activated during interpersonal interactions and close relationships. We postulated that warmth‐liking has a specific somatovisceral signature, which is, however, qualified by individual differences in personality and attachment style. Individual differences in personality and attachment style are postulated to contribute to μ‐opiate functioning. Forty‐eight females in a heterosexual relationship, selected on the basis of attachment reports, took part in a virtual ball‐tossing game with their partners and two confederates. Participants received either the competitive μ‐opioid antagonist naltrexone (25 mg) or a placebo in a randomized double‐blind design. Social exclusion during the game reduced feelings of warmth, increased feelings of anger, and increased blood pressure and left‐ventricular contractibility, whereas social inclusion was characterized by physiological quiescence. Further analyses revealed differential effects in self‐reported feelings as well as in cardiovascular parameters as a function of attachment style. Secure attachment predicted higher levels of warmth‐liking, physiological quiescence, and less negative feelings even during social exclusion. These findings can be interpreted as evidence for psychophysiological resilience. Furthermore, naltrexone reduced feelings of warmth and increased vasoconstriction during social inclusion, especially for securely bonded participants. These findings are remarkable hints for an opioidergic modulation of the interaction between emotion and personality. J. Comp. Neurol. 524:1712–1726, 2016. © 2015 Wiley Periodicals, Inc.
Degeneration of proprioceptive sensory nerve endings in mice harboring amyotrophic lateral sclerosis–causing mutations
Authors: Vaughan Sydney K. , Kemp Zachary , Hatzipetros Theo , Vieira Fernando , Valdez Gregorio 
Published: July 2015

ABSTRACTAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily targets the motor system. Although much is known about the effects of ALS on motor neurons and glial cells, little is known about its effect on proprioceptive sensory neurons. This study examines proprioceptive sensory neurons in mice harboring mutations associated with ALS, in SOD1G93A and TDP43A315T transgenic mice. In both transgenic lines, we found fewer proprioceptive sensory neurons containing fluorescently tagged cholera toxin in their soma five days after injecting this retrograde tracer into the tibialis anterior muscle. We asked whether this is due to neuronal loss or selective degeneration of peripheral nerve endings. We found no difference in the total number and size of proprioceptive sensory neuron soma between symptomatic SOD1G93A and control mice. However, analysis of proprioceptive nerve endings in muscles revealed early and significant alterations at Ia/II proprioceptive nerve endings in muscle spindles before the symptomatic phase of the disease. Although these changes occur alongside those at α‐motor axons in SOD1G93A mice, Ia/II sensory nerve endings degenerate in the absence of obvious alterations in α‐motor axons in TDP43A315T transgenic mice. We next asked whether proprioceptive nerve endings are similarly affected in the spinal cord and found that nerve endings terminating on α‐motor neurons are affected during the symptomatic phase and after peripheral nerve endings begin to degenerate. Overall, we show that Ia/II proprioceptive sensory neurons are affected by ALS‐causing mutations, with pathological changes starting at their peripheral nerve endings. J. Comp. Neurol. 523:2477–2494, 2015. © 2015 Wiley Periodicals, Inc.
Physicochemical quality and oxidative stability of linseed (Linum usitatissimum) and camelina (Camelina sativa) cold‐pressed oils from retail outlets
Authors: Raczyk Marianna , Popis Edyta , Kruszewski Bartosz , Ratusz Katarzyna , Rudzińska Magdalena 
Published: July 2015

Cold‐pressed linseed and camelina oils have been available on the global market for many years. They are known for their high contents of polyunsaturated fatty acids (PUFAs), mainly α‐linolenic (ALA). This study aimed to evaluate the quality and oxidative stability of linseed and camelina cold‐pressed oils purchased in retail outlets in Poland. The fatty acid composition, peroxide value, acid value, anisidine value, chlorophyll pigments, carotenoid pigments, and oxidative stability of these oils were analyzed. It was found that all analyzed oils meet the standards of requirements of the Codex Alimentarius (2009) for cold‐pressed oils. The content of chlorophyll and carotenoid pigments of linseed and camelina oils was significantly different. The percentage composition of PUFAs was high in both types of oils, but it was significantly higher in linseed than in camelina oils. The results of Rancimat and PDSC tests show low oxidative stability of all tested oils, although camelina oils were more stable than linseed oils.Practical applications: Based on the study, it can be concluded that linseed and camelina oils should be included in the human diet to provide an optimal ratio of omega‐6 to omega‐3 fatty acids. The differences between tested oils of the same seed species were significant. This study shows that quick methods of testing an oils oxidative stability (Rancimat and PDSC) may be successfully applied in oil studies.The study evaluates the quality of cold‐pressed linseed and camelina oils purchased in retail outlets in Poland. The research shows a correlation (r = −0.673) between content of polyunsaturated fatty acids and oxidative stability of tested oils. Oxidative stability was determined by Rancimat test and fatty acid composition by GC‐FID.
Synthesis of the C‐8–C‐24 Fragment of Maltepolide C by Using a Tandem Di­hydroxylation/SN2 Cyclization Sequence
Authors: Mohapatra Debendra K. , Reddy D. Sai , Reddy G. Sudhakar , Yadav Jhillu S. 
Published: July 2015

AbstractA highly stereoselective synthesis of the C‐8–C‐24 fragment of maltepolide C has been achieved in a convergent and efficient manner by utilizing a tandem Sharpless asymmetric dihydroxylation (SAD)/SN2 cyclization reaction sequence as the key step. Other important steps include a Crimmins‐modified Evans aldol reaction, a Brown asymmetric allylation, a Horner–Wadsworth–Emmons olefination, and a Corey–Bakshi–Shibata (CBS) reduction.
A Convenient Approach to CF3‐Containing N‐Heterocycles Based on 2‐Methoxy‐2‐methyl‐5‐(trifluoromethyl)furan‐3(2H)‐one
Authors: Bazhin Denis N. , Kudyakova Yulia S. , Röschenthaler Gerd‐Volker , Burgart Yanina V. , Slepukhin Pavel A. , Isenov Maksim L. , Saloutin Victor I. , Charushin Valery N. 
Published: July 2015

AbstractNew synthetic routes to trifluoromethylated N‐heterocycles based on condensations of 2‐methoxy‐2‐methyl‐5‐(trifluoromethyl)furan‐3(2H)‐one with bifunctional N‐nucleophiles are described. For the first time, trifluoromethyl‐containing pyrazoles, pyrazolines and isoxazolines bearing hydrazone or oxime groups could be obtained by a one‐pot strategy based on reactions of 5‐(trifluoromethyl)furan‐3(2H)‐one with two equivalents of the corresponding hydrazines or hydroxylamine in the presence of an acid. The interaction of furan‐3(2H)‐one with ureas proceeded under mild conditions to furnish 1H‐furo[2,3‐d]imidazol‐2(3H)‐one derivatives in good yield. Further, a trifluoromethyl‐containing quinoxaline derivative was obtained by condensation of furan‐3(2H)‐one with ortho‐phenylenediamine.
Distributions of return values for ocean wave characteristics in the South China Sea using directional–seasonal extreme value analysis
Authors: Randell David , Feld Graham , Ewans Kevin , Jonathan Philip 
Published: July 2015

Estimation of ocean environmental return values is critical to the safety and reliability of marine and coastal structures. For ocean waves and storm severity, return values are typically estimated by extreme value analysis of time series of measured or hindcast sea state significant wave height HS. For a single location, this analysis is complicated by the serial dependence of HS in time and its non‐stationarity with respect to multiple covariates, particularly direction and season.Here, we report a non‐stationary extreme value analysis of storm peak significant wave height
, assumed temporally independent given covariates, incorporating directional and seasonal effects using a spline‐based methodology incorporating an ensemble of models for different extreme value thresholds. Quantile regression is used to estimate suitable thresholds. For each threshold, a Poisson process is used to estimate the rate of occurrence of threshold exceedances, and a generalised Pareto model characterises the magnitude of threshold exceedances. Covariate effects are incorporated at each stage using penalised tensor products of B‐splines to give smooth model parameter variation as a function of covariates. Optimal smoothing penalties are selected using cross‐validation, and uncertainty is quantified using bias‐corrected and accelerated bootstrap resampling.We use the model to estimate environmental return values for a location in the Makassar Strait, in the South China Sea. Return values distributions for
are estimated by simulation under the threshold ensemble model. Return values for HS are then estimated by simulating intra‐storm trajectories of HS consistent with the characteristics of the simulated storm peak events using a matching procedure. Return values for maximum individual crest elevation C are estimated by marginalisation using a pre‐specified conditional distribution for C given HS and other sea state parameters. Model validation is performed by comparing confidence intervals for cumulative distribution functions of
and HS for the period of the data with empirical sample‐based estimates. Copyright © 2015 John Wiley & Sons, Ltd.
Performance Characterization of Solid Oxide Cells Under High Pressure
Authors: Sun X. , Bonaccorso A. D. , Graves C. , Ebbesen S. D. , Jensen S. H. , Hagen A. , Holtappels P. , Hendriksen P. V. , Mogensen M. B. 
Published: July 2015

AbstractIn this work, recent pressurized test results of a planar Ni‐YSZ (YSZ: Yttria stabilized Zirconia) supported solid oxide cell are presented. Measurements were performed at 800 °C in both fuel cell and electrolysis mode at different pressures. A comparison of the electrochemical performance of the cell at 1 and 3 bar shows a significant and equal performance gain at higher pressure in both fuel cell mode and electrolysis mode. Electrochemical impedance spectroscopy revealed that the serial resistance was not affected by the operation pressure; all the other processes that are dependent on partial pressures (oxygen, steam and hydrogen) were affected by increasing the pressure. In electrolysis mode at low current density, the performance improvement was counteracted by the increase in open circuit voltage, but it has to be borne in mind that the pressurized gas contains higher molar free energy.
Outerplanar and Planar Oriented Cliques
Authors: Nandy Ayan , Sen Sagnik , Sopena Éric 
Published: July 2015

AbstractThe clique number of an undirected graph G is the maximum order of a complete subgraph of G and is a well‐known lower bound for the chromatic number of G. Every proper k‐coloring of G may be viewed as a homomorphism (an edge‐preserving vertex mapping) of G to the complete graph of order k. By considering homomorphisms of oriented graphs (digraphs without cycles of length at most 2), we get a natural notion of (oriented) colorings and oriented chromatic number of oriented graphs. An oriented clique is then an oriented graph whose number of vertices and oriented chromatic number coincide. However, the structure of oriented cliques is much less understood than in the undirected case. In this article, we study the structure of outerplanar and planar oriented cliques. We first provide a list of 11 graphs and prove that an outerplanar graph can be oriented as an oriented clique if and only if it contains one of these graphs as a spanning subgraph. Klostermeyer and MacGillivray conjectured that the order of a planar oriented clique is at most 15, which was later proved by Sen. We show that any planar oriented clique on 15 vertices must contain a particular oriented graph as a spanning subgraph, thus reproving the above conjecture. We also provide tight upper bounds for the order of planar oriented cliques of girth k for all .
Internal medicine progress note writing attitudes and practices in an electronic health record
Authors: Stewart Elizabeth , Kahn Daniel , Lee Edward , Simon Wendy , Duncan Mark , Mosher Hilary , Harris Katherine , Bell John , El‐Farra Neveen , Sharpe Bradley 
Published: July 2015

BACKGROUNDThe electronic health record (EHR) has been viewed with both praise and skepticism. Multiple editorials have expressed concerns that EHR implementation and “efficiency tools” such as copy forward and auto population have resulted in a decrement in note accuracy, relevance, and critical thinking.OBJECTIVETo evaluate the perceptions of internal medicine housestaff and attendings on inpatient progress note quality at 4 academic institutions after the implementation of an EHR.DESIGNCross‐sectional survey.MEASUREMENTSWe developed surveys that assessed housestaff and attendings opinion of current progress note quality, the impact of the EHR on quality, and the purposes of a progress note.RESULTSWe received 99 completed surveys from interns (66%), 155 from residents (49%), and 153 from attendings (70%) across 4 institutions. The majority of housestaff responded that the quality of notes was “unchanged” or “better” following the implementation of an EHR, whereas attendings believed note quality was “unchanged” or “worse.” Attendings’ perceptions of housestaff notes were significantly lower than housestaff perceptions of their own notes across all domains. With regard to the effect of copy forward and autopopulation, the majority of housestaff viewed these to be “neutral” or “somewhat positive,” whereas attendings viewed these as “neutral” or “somewhat negative.” Housestaff and attendings had nearly perfect agreement regarding the purpose of the progress note.CONCLUSIONSAttendings and housestaff disagree on the current quality of progress notes and the impact of an EHR on note quality, but agree on the purpose of a progress note. Journal of Hospital Medicine 2015;10:525–529. © 2015 Society of Hospital Medicine
Effect of ACL graft material on anterior knee force during simulated in vivo ovine motion applied to the porcine knee: An in vitro examination of force during 2000 cycles
Authors: Boguszewski Daniel V. , Wagner Christopher T. , Butler David L. , Shearn Jason T. 
Published: July 2015

ABSTRACTThis study determined how anterior cruciate ligament (ACL) reconstruction affected the magnitude and temporal patterns of anterior knee force and internal knee moment during 2000 cycles of simulated gait. Porcine knees were tested using a six degree‐of‐freedom robot, examining three porcine allograft materials compared with the native ACL. Reconstructions were performed using: (1) bone‐patellar tendon‐bone allograft (BPTB), (2) reconstructive porcine tissue matrix (RTM), or (3) an RTM‐polymer hybrid construct (Hybrid). Forces and moments were measured over the entire gait cycle and contrasted at heel strike, mid stance, toe off, and peak flexion. The Hybrid construct performed the best, as magnitude and temporal changes in both anterior knee force and internal knee moment were not different from the native ACL knee. Conversely, the RTM knees showed greater loss in anterior knee force during 2000 cycles than the native ACL knee at heel strike and toe off, with an average force loss of 46%. BPTB knees performed the least favorably, with significant loss in anterior knee force at all key points and an average force loss of 61%. This is clinically relevant, as increases in post‐operative knee laxity are believed to play a role in graft failure and early onset osteoarthritis. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1789–1795, 2015.
Quantitative comparison of the microscopic anatomy of the human ACL femoral and tibial entheses
Authors: Beaulieu Mélanie L. , Carey Grace E. , Schlecht Stephen H. , Wojtys Edward M. , Ashton‐Miller James A. 
Published: July 2015

ABSTRACTThe femoral enthesis of the human anterior cruciate ligament (ACL) is known to be more susceptible to injury than the tibial enthesis. To determine whether anatomic differences might help explain this difference, we quantified the microscopic appearance of both entheses in 15 unembalmed knee specimens using light microscopy, toluidine blue stain and image analysis. The amount of calcified fibrocartilage and uncalcified fibrocartilage, and the ligament entheseal attachment angle were then compared between the femoral and tibial entheses via linear mixed‐effects models. The results showed marked differences in anatomy between the two entheses. The femoral enthesis exhibited a 3.9‐fold more acute ligament attachment angle than the tibial enthesis (p < 0.001), a 43% greater calcified fibrocartilage tissue area (p < 0.001), and a 226% greater uncalcified fibrocartilage depth (p < 0.001), with the latter differences being particularly pronounced in the central region. We conclude that the ACL femoral enthesis has more fibrocartilage and a more acute ligament attachment angle than the tibial enthesis, which provides insight into why it is more vulnerable to failure. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1811–1817, 2015.