bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Tamsulosin 0.4 mg versus 0.8 mg in Management of Patients Suffering from Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia
Authors: Al Sayed Tarek Othman , Essam Mohammed Darweesh , Al Saeed Kareem Omar 
Published: July 2024

Abstract

Introduction
Lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) are common among older men. Beside watchful waiting and surgery, medical therapy includes alpha adrenergic blockers, 5 alpha reductase inhibitors, and phytotherapy. Alpha blockers are considered to be the main treatment for BPH-associated LUTS depending on the evidence that prostatic smooth muscle contraction is responsible for bladder outlet obstruction via alpha adrenergic receptor- mediated mechanism. Tamsulosin is a super selective alpha blocker. Improvement of LUTS can be assessed by maximum flow rate (Qmax), average flow rate (Qavg), post void residual (PVR) urine volume and international prostate symptom score questionnaire (IPSS).

Objectives
To compare the efficacy and the safety of Tamsulosin 0.4 mg/day and 0.8 mg/day in patients suffering from lower urinary tract symptoms due to benign prostatic hyperplasia.

Patients and Methods
A Prospective Interventional, double-blinded, controlled study was carried out on 93 patients who met the criteria and divided randomly into 2 groups; group A for Tamsulosin 0.4 mg/day and group B for Tamsulosin 0.8 mg/day. International prostate symptom score, Post void residual urine volume, and maximum flow rate of urine were assessed before and after 4 weeks of treatment.

Results
Both study groups showed a significant reduction in storage sub-score but only frequency was significantly reduced in group B (P &lt; 0.001). On the other hand, Tamsulosin 0.8 mg was superior to Tamsulosin 0.4 mg regarding voiding sub score except for straining (P = 0.325). Accordingly, the total international prostate symptom score was significantly improved in group B (P &lt; 0.001). Furthermore, maximum flow rate and post-void residual urine volume were notably improved with Tamsulosin 0.8 mg compared to Tamsulosin 0.4 mg (P &lt; 0.001). Although the adverse events; such as headache, orthostatic hypotension, and retrograde ejaculation were more frequent, but not significant, to occur with Tamsulosin 0.8 mg, only dizziness was noted to be significant.

Conclusion
Tamsulosin 0.8 mg has shown better outcomes in treating patients who suffer from lower urinary tract symptoms due to benign prostatic hyperplasia than Tamsulosin 0.4 mg, and besides that, it is well tolerated.
Evaluation of the Role of Preoperative Pharmacological Ureteral Dilatation in Ureteroscopic Stone Surgery
Authors: Kotb Youssef Mahmoud , Hefnawy Ahmed , Ahmed Khaled Adel 
Published: July 2024

Abstract

Background
Urinary stone disease is very common, with an estimated prevalence among the general population of 2% to 3% and an estimated lifetime risk of 1 in 8 for white males and 5% to 6% for white females, with men forming stones three times as often as women.

Aim of the Work
To compare the effectiveness of antispasmodics (hyoscine-N- butylbromide), α-blockers (tamsulosin), placebo as control (in the form of multivitamins), as preoperative medications for ureteral dilatation prior to semirigid ureteroscopic stone surgery.

Patients and Methods
This prospective randomized control clinical study conducted on 90 patients admitted from Urology department, Faculty of Medicine, Ain Shams University hospitals in a period of 6 months starting from March 2022 till September 2022; they were randomized into 3 groups 30 patients per group: Group (A) received Tamsulosin 0.4 mg once daily for 7 days, Group (B) received Hyoscine-N- butylbromide 10 mg three times per day for 7 days, Group (C) received Placebo.

Results
The operation time and the need of double J stent insertion significantly decrease with Tasmulosin or Hyoscine-N-butylbromide versus Placebo. Operative and postoperative complications significantly decrease while using Tamsulosin or Hyoscine- N-butylbromide versus Placebo.

Conclusion
The administration of adjunctive alpha-blockers and/or antispasmodics prior to ureteroscopic management of lower ureteric stones seems to be associated with better advancing of the ureteroscope to access the stone, shorter procedure time, higher stone-free rate, lower incidence of intra- and postoperative complications and lesser need for postoperative analgesia.
Validation of two automatic sphygmomanometers according to the modified International Standardization Organization 81060-2:2018 protocol in adults with a mid-upper arm circumference of 22 centimeters or less
Authors: Posokhov Igor N. , Praskurnichiy Evgeny A. , Orlova Olga S. , Sukhodolova Ekaterina A. , Lystseva Aleksandra V. 
Published: July 2024

Objective
A recent International Organization for Standardization (ISO) Task Group report calls for research to investingate potential special populations in validation studies of automated blood pressure (BP) devices. Accordingly, we aimed to determine the accuracy of two previously validated BP monitors passed in a general population when measured in adults with a mid-upper arm circumference (MUAC) ≤ 22 cm.

Methods
Test device A was the OMRON HEM 7121 equipped with the HEM CS24 cuff designed for an arm circumference of 17–22 cm. Test device B was the YuWell YE660Е with the YuWell ‘360°’ cuff (18–36 cm). Data from 37 participants aged 20.14 ± 2.23 (18–28) years were analyzed according to criterion 1 of ISO Standard 81060-2 : 2018.

Results
According to criterion 1, the mean ± SD of the BP differences for the device A was −7.81 ± 5.20/−10.66 ± 5.48 mmHg (systolic/diastolic) and for the device B was −8.00 ± 6.30/−16.11 ± 5.15 mmHg (systolic/diastolic), respectively. This means that neither device met the requirements.

Conclusion
Since devices A and B, which had passed in a general population study, failed in adults aged 18–28 years with an MUAC ≤ 22 cm, such individuals might be considered as new special population for validation studies.
Anatomical Comparison of Endoscopic and Microscopic Exposure of the Petroclinal Core Area Through the Extended Middle Skull Base Approach
Authors: Sun Guoqing , Wang Hu , Shang Yanguo , Shi Minggang , Wang Xuan , Tong Xiaoguang 
Published: July 2024

Objective:
To compare the range of endoscopic and microscopic exposure of the petroclival core area through the middle skull base and to observe the corresponding anatomical structures.

Methods:
Ten intact adult cadaveric head specimens fixed with formaldehyde were craniotomized through an expanded middle skull base epidural approach on 20 sides. The distance from the greater superficial petrosal nerve to the petrous ridge was measured. When different degrees (1–3 degrees) of the Kawase triangle bone were removed, the exposed anatomical structure was observed, and the exposed core area of the rock slope was measured under an endoscope and microscope.

Results:
The average distance from the greater superficial petrosal nerve to the petrous ridge was 14.26 mm. During 1 to 2 degrees of bone removal, the petrous segment of the internal carotid artery (ICA) was not exposed, whereas during 3 degrees of bone removal, the petrous segment of the ICA was exposed. At 1 degree of bone removal, 400.62 ± 15.73 mm2 of the area was exposed by endoscopy and 170.87 ± 8.93 mm2 by microscopy, and the abducens nerve was not exposed. However, there was a significant difference between the two areas (P < 0.001). During 2 degrees of bone removal, 689.30 ± 32.06 mm2 of the abducens nerve was exposed by endoscopy, but 366.84 ± 30.30 mm2 of the abducens nerve could not be exposed by microscopy; moreover, there was a significant difference in the area of exposure between the two (P < 0.001). At 3 degrees of bone removal, the endoscopic exposure area was 875.92 ± 31.87 mm2, the microscopic exposure area was 699.26 ± 48.00 mm2, and the abducens nerves were exposed. There were significant differences between the two areas (P < 0.001). However, the difference between the 2-degree endoscopic exposure area and the 3-degree microscopic exposure area was studied by using paired t tests, and there was no difference (P > 0.05).

Conclusion:
When the same degree of the Kawase triangle bone was removed, the extent of endoscopic exposure of the petroclival core area was significantly greater than the extent of microscopic exposure. At 2 degrees of bone removal, an endoscopic application can maximally expose the petroclival core area, thus reducing the probability of exposure damage to the ICA and abductor nerve.
Healthcare Students' Experiences of Learner-Educator Cocreation of Virtual Simulations
Authors: Killam Laura A. , Åkerlind Gerlese S. , Lock Mercedes , Camargo-Plazas Pilar , Luctkar-Flude Marian 
Published: July 2024

Introduction
Cocreating virtual simulations with learners during a course is an innovative approach to improving student preparation for real-world practice while helping simulationists meet learner needs, support authentic assessment, and maximize the impact of simulation-based learning. This study explores differences in healthcare students' experiences of learner-educator cocreation of virtual simulations (LECoVSs) using phenomenographic methods. Identifying differences in perceptions of LECoVSs enables educators to make evidence-informed decisions about engaging in simulation cocreation as a tool to maximize learning.

Methods
Phenomenography focuses on identifying different ways that participants can experience the same phenomenon, in this case, LECoVSs. The setting was a collaborative interprofessional simulation assignment between navigation and nursing students. Participants completed a demographic survey then submitted reflective journals completed during the course and/or an open-ended survey. Data analysis occurred in iterative stages, from familiarization with the data to grouping and interpreting themes.

Results
Nineteen open-ended surveys and 13 reflective journals from navigation and nursing students who completed the simulation assignment between 2021 and 2023 were analyzed. Students experienced LECoVSs in 4 increasingly complex ways: (1) supporting consistent student progress, (2) amending course expectations, (3) sharing decision-making, and (4) fostering mutual growth.

Conclusions
Simulationists may leverage cocreation to improve student learning, access, empowerment, and professional growth. However, for students to achieve higher learning outcomes, educators need to clearly communicate the full potential of cocreation, how it can occur, and why it can support learning. This study's findings may be used as a framework for explaining simulation cocreation to students to maximize their learning.
HIV-1 control in vivo is related to the number but not the fraction of infected cells with viral unspliced RNA
Authors: Capoferri Adam A. , Wiegand Ann , Hong Feiyu , Jacobs Jana L. , Spindler Jonathan , Musick Andrew , Bale Michael J. , Shao Wei , Sobolewski Michele D. , Cillo Anthony R. , Luke Brian T. , Fennessey Christine M. , Gorelick Robert J. , Hoh Rebecca , Halvas Elias K. , Deeks Steven G. , Coffin John M. , Mellors John W. , Kearney Mary F. 
Published: July 2024

AbstractIn the absence of antiretroviral therapy (ART), a subset of individuals, termed HIV controllers, have levels of plasma viremia that are orders of magnitude lower than non-controllers who are at higher risk for HIV disease progression. In addition to having fewer infected cells resulting in fewer cells with HIV RNA, it is possible that lower levels of plasma viremia in controllers is due to a lower fraction of the infected cells having HIV-1 unspliced RNA (HIV usRNA) compared with non-controllers. To directly test this possibility, we used sensitive and quantitative single cell sequencing methods to compare the fraction of infected cells that contain one or more copies of HIV usRNA in peripheral blood mononuclear cells (PBMC) obtained from controllers and non-controllers. The fraction of infected cells containing HIV usRNA did not differ between the two groups. Rather, the levels of viremia were strongly associated with the total number of infected cells that had HIV usRNA, as reported by others, with controllers having 34-fold fewer infected cells per million PBMC. These results reveal for the first time that viremic control is not associated with a lower fraction of proviruses expressing HIV usRNA, unlike what is reported for elite controllers, but is only related to having fewer infected cells overall, maybe reflecting greater immune clearance of infected cells. Our findings show that proviral silencing is not a key mechanism for viremic control and will help to refine strategies towards achieving HIV remission without ART.
Eco-Microbiology: Discovering Biochemical Enhancers of PET Biodegradation byPiscinibacter sakaiensis
Authors: Piedra Felipe-Andrés , Salazar Miguel A. , Rahman Raayed , Clark Justin C. , Maresso Anthony 
Published: July 2024

AbstractThe scale of plastic pollution boggles the mind. Nearly 400 megatons of virgin plastics are produced annually, with an environmental release rate of 80 percent; and plastic waste including micro- and nanoplastics are associated with a plethora of problems. The naturally evolved abilities of plastic-degrading and consuming microbes offer a starting point for generating sustainable and eco-centric solutions to plastic pollution. Here we developed an iterative discovery procedure coupling faster quasi-high-throughput polyethylene terephthalate (PET) dependent bioactivity screens with longer-term PET biodegradation assays to find small molecule and ionic boosters of PET consumption by the bacteriumPiscinibacter sakaiensis. We discovered multiple hits supporting greater than 2-fold enhancement of PET biodegradation – with hits belonging to a small but heterogeneous set of compounds and mixtures, suggesting upregulation of PET consumption via multiple paths. This work has the potential to advance the creation of a fermentation-based process for solving PET plastic pollution.ImportancePlastic pollution is an urgent environmental issue. In addition, micro- and nanoplastics (MNPs) have become an acute source of worry with discoveries of the global distribution and transport of MNPs, their presence within a diversity of organisms including common foodstuffs and human tissues, and their potential association with declining fertility and various disease states. Solutions are needed and the microbial world offers abundant help via naturally evolved biodegraders of plastic waste. We created a non-genetic method to accelerate polyethylene terephthalate (PET) plastic biodegradation byPiscinibacter sakaiensis, a bacterium that evolved to slowly but completely consume PET. Our method entails a combination of plastic-dependent bioactivity screens and slower biodegradation tests to find extrinsic biochemical stimulators of PET biodegradation. The conditions we found boost PET biodegradation by over two-fold and provide a foundation for further studies to realize a fermentation-based process needed to solve PET plastic pollution.
The relationship between love of money, peer influence and personality traits on unethical behaviour of graduate accounting students
Authors: Sabah Welbeck Edem Emerald , Bremang Mabel Ohenewaa 
Published: July 2024

Purpose
This study aims to analyse the impact of love of money, personality traits and peer influence on the ethical behaviour of graduate accounting students at the University of Ghana Business School.

Design/methodology/approach
This study used a quantitative research approach to sample postgraduate accounting students who completed a self-administered questionnaire on the variables of interest. Using partial least square–structural equation modelling, the hypothesized relationships were examined based on 328 appropriate responses received for the questionnaire.

Findings
The empirical findings suggest that peer influence and personality trait, extraversion positively and significantly influence unethical behaviour, whereas the personality traits, agreeableness and openness to experience have a negative and significant relationship with unethical behaviour. The study, however, does not find support for the hypothesized relationships between the love of money, personality traits (conscientiousness, neuroticism) and unethical behaviour.

Originality/value
The study contributes to the literature on unethical behaviour, highlighting how decision-making factors such as love of money, peer influence and personality traits, respectively, influence unethical behaviour explained by the self-justification concept under the social cognitive and moral reasoning theory. This could aid these potential managers in seeking higher reviews on ethical dilemmas. It could also aid the professional body and academics in Ghana particularly to intensify ethical education for students of the profession.
University teachers at the crossroads: unpacking their intentions toward ChatGPT's instructional use
Authors: Jaffar Muhammad , Jogezai Nazir Ahmed , Abdul Latiff Abdul Rais , Baloch Fozia Ahmed , Khilji Gulab Khan 
Published: July 2024

PurposeThe objective of this study was to elucidate the intentions of university teachers regarding the utilization of ChatGPT for instructional purposes.Design/methodology/approachIn this cross-sectional quantitative research, data were collected through an online survey tool from 493 university teachers across Pakistan.FindingsThe findings revealed that positive attitudes and a sense of perceived behavioral control had a positive impact on teachers' adoption of ChatGPT for instructional purposes. Conversely, subjective norms exhibited a significant negative influence. The results underscore that teachers are inclined to embrace ChatGPT for instructional cause due to their recognition of its educational utility. However, it does not appear that their social environment, which includes their coworkers and managers, has a significant impact on how they decide what to do.Research limitations/implicationsThe findings bear implications for devising relevant policies that support AI integration in curricula and assessments and teachers’ professional development (PD) programs. There is a need for formulating guidelines at the universities and the policy tiers to make the ChatGPT use more relevant. Future research should strive to generate insights toward AI use in the areas of curriculum, assessment and teachers’ PD.Originality/valueThe study adds to the relatively new literature on the integration of ChatGPT in higher education. This study’s findings contribute to the body of knowledge related to AI’s pedagogical use and set future directions to consider factors influencing meaningful and responsible use of AI in teaching and learning.
Unveiling the path to green innovation: the interplay of green learning orientation, knowledge management capability and manufacturing firm’s capability to orchestrate resources
Authors: Baquero Asier 
Published: July 2024

Purpose
Amidst the increasing global emphasis on environmental sustainability, manufacturing firms seek to integrate eco-conscious practices into their innovation processes. This study aims to explore the intricate relationships between green learning orientation (GLO), knowledge management capability (KMC), resource orchestration capability (ROC) and two dimensions of green innovation (GI): green product innovation (GPDI) and green process innovation.

Design/methodology/approach
Partial least squares structural equation modelling (PLS-SEM) and moderated mediation techniques were used to investigate the relationships among the constructs using data gathered from a survey of 167 manufacturing firms in the United Arab Emirates.

Findings
This study indicates that GLO significantly influences GPDI and green process innovation. Although KMC mediates the relationship between GLO and process innovation, it does not mediate the GPDI relationship. Moreover, ROC significantly strengthens the links between GLO, KMC and both the aspects of GI.

Practical implications
This study emphasises the importance of fostering a green learning culture and integrating it into product development without complex knowledge management systems. This study also highlighted the role of effective resource allocation in maximising environmental learning benefits for sustainable innovation. Organisations can achieve environmental progress by integrating green knowledge into product and process development and by investing in sustainable practices.

Originality/value
By examining various mechanisms involving moderation and mediation, this study has made a notable contribution to advancing the field of knowledge-based view theory. This study also offers enhanced insights into the interconnections among GLO, knowledge management capability, ROC and a firm’s capacity for GI.
A systematic review of paradoxes linked with digital transformation of business
Authors: Singh Nidhi , Vishnani Sushma , Khandelwal Vinay , Sahoo Saumyaranjan , Kumar Satish 
Published: July 2024

PurposeThis review study aims to explore the prevalent paradoxes in digital transformation (DTN) of business and provide insights on how businesses can effectively navigate them.Design/methodology/approachThe study conducts a systematic literature review, utilizing findings from a bibliometric analysis. A sample of 229 articles published in top-tier journals, retrieved from the Scopus database, is reviewed to identify nine clusters representing different sectors and paradoxes in DTN.FindingsThe review identifies and summarizes studies addressing the paradoxes that arise during DTN in various sectors. Scholars have analyzed the growing need for digital innovations and the benefits they bring, but this study aggregates high-quality research to address the gap in understanding prevalent paradoxes.Originality/valueThis study provides valuable insights into the paradoxes of DTN and offers guidance to businesses on effectively managing these challenges. It contributes to the existing literature by consolidating and presenting key research findings in this domain.
Workplace romance – ready or not? Complex antecedent conditions supporting (discouraging) concupiscence
Authors: Doll Jessica L. , Woodside Arch George 
Published: July 2024

PurposeThis study applies complexity theory to propose and empirically examine asymmetric case conditions of antecedents and outcome models of high (low) willingness-to-engage in workplace romance (WEWR). This study focuses on constructing complex antecedent conditions that accurately indicate which employees, and under what conditions, employees are high in WEWR.Design/methodology/approachUsing an experimental design, 162 employees were assigned one of nine hypothetical vignettes describing different workplace romance contexts including three discrete policies regarding workplace romances (i.e. strictly forbidden, moderate, vs no policy), two motivations for the workplace romance (i.e. job vs love), and two organizational positions of the romance (i.e. hierarchical vs lateral). Participants then reported WEWR responses. Participants also provided demographic, behavioral, and psychological work-related information. This study assesses and supports recipes (i.e. algorithms) of case and organizational structure conditions to identify cases high (low) in WEWR accurately and consistently.FindingsThe results provide clarity of which and when employees are willing vs unwilling to engage in workplace romances – and the contextualized impacts of organizational bans on WEWR. The study’s results are useful for estimating for whom specific workplace policies are effective or not by specific workplace contexts.Practical implicationsIn highlighting the role of varying antecedent conditions in predicting WEWR, this research will assist organizations and practitioners in understanding the context in which workplace romances are more likely to occur, providing insight as to when employees are likely to comply with workplace romance policies.Originality/valueThis paper is the first in the workplace romance literature to examine unique combinations of antecedent conditions on WEWR, adding nuance to the current understanding of the behavior.