bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Sex Differences on Stroke Risk Factors and 3-Month Outcomes in Patients Receiving Thrombolytic Therapy for Acute Ischemic Stroke
Authors: Khedr Eman M. , Abo-Elfetoh Noha , Hasan Asmaa M. , Nasreldein Ahmed , Haridy Nourelhoda A. 
Published: August 2024

Abstract

Background: Acute ischemic stroke (AIS) is a major public health issue, and women have a disproportionate share of stroke-related disability and mortality, which is poorly understood. This study aimed to determine the effect of sex differences on AIS treated by thrombolysis using recombinant tissue plasminogen activator (rTPA). The study included 134 AIS patients (59% males and 41% females). Risk factors, clinical presentation, thrombolysis response, complications, and outcomes were recorded. The outcomes were measured using the National Institute of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) three months after stroke. The incidence of intracranial haemorrhage was also determined.
Results: Among 134 AIS patients treated with rTPA (59% male, 41% female), females had higher rates of hypertension (67.3% vs 49.4%, p=0.040) and atrial fibrillation (AF) (12.7% vs 2.5%, p=0.020), while smoking was more prevalent in males (31.6% vs 0%, p<0.0001). Cardioembolism was more frequent in females (23.6% vs 6.3%, p=0.004), who also had shorter onset-to-door (110.7±63 vs 131.1±50.2 min, p=0.035) and onset-to-needle times (151.6±66.5 vs 173.7±50.6 min, p=0.046). Both sexes showed significant improvements in NIHSS (males: 11.58±3.7 to 6.05±5.6; females: 11.64±4.7 to 6.9±5.9; p<0.0001) and mRS scores (males: 3.34±1.05 to 2.03±2; females: 3.53±1 to 2.02±2; p<0.0001) over three months, with no significant differences between sexes. Predictors of poor outcome (mRS 3-6) differed: diabetes millites (DM) (OR 7.79, p=0.002) and longer door-to-needle time (OR 1.04, p=0.008) for males, and hemorrhage (OR 9.41, p=0.048) for females. Hemorrhage predicted mortality in males (OR 27.08, p<0.0001), while AF was associated with increased mortality in females (OR 8.06, p=0.024).
Conclusions: This study revealed sex-specific differences in AIS risk factors, etiology, and rTPA treatment timelines, although post-treatment improvements were comparable between sexes. Notably, outcome predictors and mortality factors differed by sex. These findings emphasize the need for sex-specific considerations in AIS management and risk assessment.
Mild hypothermia alleviates cardiomyocyte necroptosis after cardiopulmonary resuscitation by regulating TRPV1
Authors: Yin Meixian , Liu Chuiliang , Zhu Yifang , Zhan Haohong , Lu Yuanzheng , Liu Keke , Lu Yawen , Zhang Sibo , Zhang Chenyu , Liu Rong , Li Yingqing , Guo Zhiyong , He Xiaoshun , Hu Chunlin 
Published: August 2024

Abstract

Background Therapeutic mild hypothermia (MH) is expected to improve the neurological outcome and the survival rate of CPR after cardiac arrest (CA). However, whether and how mild hypothermia protects cardiomyocytes largely remains to be explored.
Methods Three to four-month-old (age), 319.1-480.0 g (weight), male (sex) Wistar rats were randomly divided into normothermia (NT) groups (acceptable range, 36.0-38.0°C) and MH groups (acceptable range, 32-34°C). Then ten minutes after CA, CPR was perfumed by a slow injection of 0.30-0.50 mL epinephrine solution (30.00 μg/mL). Moreover, to test the effect of TRPV1, capsaicin was injected through the right femoral artery both in NT groups and MH groups.
Results We found that MH improved the recovery of spontaneous breathing, increased survival rate, and inhibited cardiac necroptosis of Wistar rats after CPR. Moreover, MH alleviated primary cardiomyocytes necroptosis after oxygen-glucose deprivation and reperfusion through up-regulating TRPV1, down-regulating EGFR, and subsequently suppressing MLKL. Furthermore, capsaicin, the TRPV1-activator, combined with MH, improved the blood pressure of Wistar rats after CPR when compared with MH alone. Capsaicin improved the spontaneous breathing rate and survival rate of Wistar rats after CPR.
Conclusions MH may protect cardiac function by TRPV1-inhibited cardiomyocyte necroptosis.
Smartwatch-Assisted Exercise Prescription: Utilizing Machine Learning Algorithms for Personalized Workout Recommendations and Monitoring: A review
Authors: Jubair Hassan , Mehenaz Mithela 
Published: August 2024

Abstract

This review paper examines the intersection of wearable technology, machine learning algorithms, and exercise prescription, focusing on the utilization of smartwatches to monitor physiological data during workouts. With the proliferation of smartwatches equipped with sensors capable of capturing various biometric parameters, alongside the advancements in machine learning, personalized exercise recommendations have become increasingly feasible. Through a synthesis of existing literature and analysis of recent developments, this paper explores the potential of integrating wearable technology and artificial intelligence to optimize exercise routines tailored to individual needs and goals. Key topics covered include the types of sensors found in smartwatches, machine learning algorithms used for exercise prescription, practical applications, challenges, and future directions. By providing insights into the current landscape and emerging trends, this review aims to inform researchers, practitioners, and policymakers on the opportunities and challenges in leveraging wearable technology and machine learning for personalized fitness monitoring and exercise prescription.
A study of chronic suppurative otitis media cases in Damascus Hospital and the Red Crescent Hospital
Authors: Khair Hala , Ali Hasan , Nahas Louei 
Published: August 2024

Abstract

Research objective: To study cases of chronic suppurative otitis media, their symptoms and factors that predispose to its occurrence, and to study the surgical methods used in treatment in cases with both malignant and benign manifestations.
Methods and materials: A retrospective study was conducted on a sample of 131 patients with chronic suppurative otitis media attending Damascus Hospital and the Red Crescent Hospital in Damascus during the years from 2014 AD to 2020 AD. The samples were collected through a paper form, and the data were analyzed through a statistics program. SPSS-26, and p>Value<0.05 was considered statistically significant.
Results: The sample size was 131 patients, and the percentage of males and females was 40.5% and 59.5%, respectively. The average age of the patients was (41.6) with a standard deviation of (6.2). The percentage of infection in the left ear was 51.1%, the most common in the right ear was 48.1. The most common symptom observed was gonorrhea. Itching, hearing loss, and tinnitus occurred at a rate of 89.3%. Most of the types of gonorrhea were intermittent and continuous, at rates of 44.2% and 29%, respectively. Most patients had moderate to severe hearing loss at rates of 38.9% and 19.8%, respectively.
Most of the patients had mixed and conductive hearing loss, with rates of 38.9% and 34.4%, respectively. The rate of perforation of the central and marginal tympanic membrane was 50.4% and 13.7%, respectively. The most common risk factors for allergic rhinitis, frequency deviation, and keratinomegaly were 24.4%. % and keratomegaly alone 24.4%, the most common complication is ossicle sclerosis at 8.3%, and 90.9% were managed surgically, there is a significant relationship between the bony air gap and the type of perforation (benign and malignant), (P, 0.02), there is a significant relationship between the condition of the ossicles. (benign, sclerosis, necrosis), and perforation pattern (benign, malignant), (P, 0.009).
Assessment of Textile Effluent Quality: A Laboratory Analysis of ETP Effectiveness in Meeting ECR Standards
Authors: Dipu Salah Uddin Ahmed 
Published: August 2024

Abstract

The textile sector contributes significantly to industrial pollution, especially by the release of effluents comprising dyes, chemicals, and other contaminants (Islam & Mostafa, 2019). Proper treatment of these effluents is critical for reducing their environmental impact. The purpose of this study is to analyze the effluent quality of FOURH Textile, a renowned textile manufacturing company, by examining samples collected before and after treatment at their Effluent Treatment Plant (ETP). The evaluation aims to determine if the treated effluent meets the Environmental Conservation Rules (ECR) requirements established by the regulatory authorities. Effluent samples were obtained from FOURH Textile's plant, focusing on the untreated (influent) and treated (effluent) streams. These samples were subjected to a battery of laboratory tests to determine pH, biochemical oxygen demand (BOD), chemical oxygen demand (COD), total suspended solids (TSS), and heavy metal levels(Nergis et al., 2009). This study compares the findings of untreated and treated effluents to assess the effectiveness of the ETP in lowering pollutant levels to acceptable limits as per ECR standards. The conclusions of this investigation will shed light on the ETP's performance at FOURH Textile, as well as its compliance with environmental requirements.
Bed shear stress distribution across a meander path
Authors: Pradhan Arpan , Khatua Kishanjit Kumar , Sahoo Kirti Kanta , Mohanta Abinash , Beulah M. , Sudhir M. R. 
Published: August 2024

ABSTRACT
Laboratory experimentation for bed shear stress distribution has been carried out in two sets of meandering channels. The channels have crossover angles of 110° and 60° constructed by ‘sine-generated’ curves over a flume of 4 m width. Variations in bed roughness were studied for the meandering main channel. Bed shear stress distribution across a meandering length for the 110° and 60° channels was examined for different sinuosities and roughnesses. The boundary shear stress study illustrated the position of maximum shear along the apex section and across the meandering path. These variations were observed for different flow depths. A comparison of the bed shear among the three experimental channels was conducted, and the results were analyzed.
Transport and Fate of Nitrate in a Saturated Buffer Zone as Assessed With a Chloride Tracer Test
Authors: Sahad Alhassan , Peterson Eric W. 
Published: August 2024

ABSTRACT
The Upper Mississippi Basin, which includes Illinois, has highly fertile soils and experiences intensive agricultural practices. Although fertile, the soils do not drain well, resulting in the installation of tile-drainage systems. The practices of tile systems coupled with the application of nitrogen-rich fertilizers have led to the excessive export of nitrate from the agricultural fields into surface waters, contributing to eutrophication and the development of hypoxic zones in aquatic environments. Saturated riparian buffer zones (SRBs) have been proposed as a means to reduce the amount of nitrate discharged from tile-drained waters into streams. Previous works show a reduction in the nitrate as waters travel through an SRB, but in situ measurements of travel times are limited. Using the results from a 52-day tracer test, we developed a mathematical model combining end-member mixing of a tracer, chloride, and concentrations of nitrate as nitrogen (NO3-N) to determine the travel time of the tile waters in an SRB and to quantify the amount of NO3-N reduction occurring within an SRB. For the first 30 days, dissolved oxygen (DO) concentrations indicated aerobic conditions within the waters of most of the SRB, which saw a concomitant increase in NO3-N concentrations along groundwater pathways. As DO concentrations decreased below 4.5 mg/L, NO3-N concentrations began to lower along the flow pathways, resulting in NO3-N reductions ranging from 23 to 97 percent.
Construction and Biological Evaluation of Different Nanoshell Thickness Ni@SiO2 Nanotubes as Good Protein Separation Carriers for Bovine Hemoglobin
Authors: Cheng Xiaomei , Liu Chang , Cai Yuanyuan , Li Xiangzi , Zhao Ruirui , Feng Yan , Wang Meifang 
Published: August 2024

Background:
Nickel nanomaterials play an important role in biological applications,
but they have high toxicity and poor biocompatibility. To overcome these defects,
we coated the surface of Ni nanotubes with different thicknesses of SiO2 to reduce
cytotoxicity, improve biocompatibility, and broaden their biological application value.

Objective:
This study aimed to construct Ni nanotubes with different thicknesses of SiO2
nanoshells; investigate the effects of silicon layer thickness, incubation time, and cell
line category on the cytotoxicity of the as-synthesized materials, and evaluate the biocompatibility
of the materials by biological enzymes. The Ni@SiO2-NH2 was selected
for use as an adsorbent for the adsorption and purification of histidine-rich proteins,
such as Bovine Hemoglobin (BHb).

Methods:
Magnetic Ni nanotubes were prepared by the template-chemical deposition
method. A modified version of the Stöber process was used for the SiO2 coating of
Ni@SiO2 nanotubes, and adjusted by changing the volume of TEOS for different thicknesses
of SiO2 nanoshells.

Results:
Different cell lines containing tumor cells and normal cells were used in the
toxicity experiment, which confirmed the low cytotoxicity and good biocompatibility of
Ni@SiO2. To achieve high efficiency of immobilization and purification of histidine-
rich proteins, Ni@SiO2-NH2 was obtained by introducing the amino functional
group. The Ni@SiO2-NH2 was found to possess lower cytotoxicity and higher adsorption
capacity compared to other synthesized materials. Besides, the Ni@SiO2-NH2 also
exhibited good selectivity of histidine-rich proteins.

Conclusion:
This work has not only provided ideas for reducing the cytotoxicity and improving
the biocompatibility of biological nanomaterials, but also laid a foundation for
subsequent biological applications.
The Role of Intracellular and Extracellular Vesicles in the Development of Therapy Resistance in Cancer
Authors: Wilczak Magdalena , Surman Magdalena , Przybyło Małgorzata 
Published: August 2024

:
Cancer is the second leading cause of global mortality and claims approximately 10 million lives annually.
Despite advances in treatments such as surgery, chemotherapy, and immunotherapy, resistance to these
methods has emerged. Multidrug resistance (MDR), where cancer cells resist diverse treatments, undermines
therapy effectiveness, escalating mortality rates. MDR mechanisms include, among others, drug inactivation,
reduced drug uptake, enhanced DNA repair, and activation of survival pathways such as autophagy. Moreover,
MDR mechanisms can confer resistance to other therapies like radiotherapy. Understanding these mechanisms
is crucial for improving treatment efficacy and identifying new therapeutic targets. Extracellular vesicles
(EVs) have gathered attention for their role in cancer progression, including MDR development through
protein transfer and genetic reprogramming. Autophagy, a process balancing cellular resources, also influences
MDR. The intersection of EVs and autophagy further complicates the understanding of MDR. Both extracellular
(exosomes, microvesicles) and intracellular (autophagic) vesicles contribute to therapy resistance
by regulating the tumor microenvironment, facilitating cell communication, and modulating drug processing.
While much is known about these pathways, there is still a need to explore their potential for predicting treatment
responses and understanding tumor heterogeneity.
Factors Influencing Primary Care Access for Common Mental Health Conditions Among Adults in West Africa: Protocol for a Scoping Review
Authors: Adjei-Banuah Nhyira Yaw , Ayiku Roberta Naa Barkey , Reichenberger Veronika , Sasu David , Mirzoev Tolib , Murphy Adrianna , Ohene Sammy , Antwi Edward , Agyepong Irene Akua 
Published: August 2024

Background
Mental health conditions are expressed in various ways in different people, and access to health care for these conditions is affected by individual factors, health care provider factors, and contextual factors. These factors may be enablers or barriers to accessing primary care for mental health conditions. Studies have reported a gap in treatment for mental health conditions in many countries in West Africa due to barriers along the access pathway. However, to the best of our knowledge, there is yet to be a review of the factors influencing access to primary care for common mental health conditions among adults in West Africa.

Objective
Our scoping review will explore the factors influencing access to primary care for common mental health conditions among adults aged 18 years and older in West Africa from 2002 to 2024.

Methods
Our review will follow the approach to scoping reviews developed by Arksey and O’Malley in 2005. This approach has five stages: (1) identifying the research question; (2) identifying relevant studies; (3) selecting studies; (4) charting the data; and (5) collating, summarizing, and reporting the results. We will search electronic databases (PubMed, Embase, PsycINFO, Cairn.info, and Google Scholar), source gray literature from relevant websites (the World Health Organization and country-specific websites), and manually explore reference lists of relevant studies to identify eligible records. Pairs of independent authors (NYA-B, RNBA, VR, or DS) will screen the titles, abstracts, and full texts of studies based on predefined eligibility criteria. We will use a data extraction tool adopted from the JBI Manual for Evidence Synthesis to chart the data. Deductive, thematic analysis will be used to categorize factors influencing access to mental health care under predetermined themes. New themes derived from the literature will also be charted.

Results
Database searches were conducted between February 1, 2024, and February 12, 2024. As of July 2024, the review report is being drafted, and it will be disseminated through publication in a peer-reviewed journal.

Conclusions
The results of the review will inform decision-making on policies, programs, and their implementation in West Africa to improve primary care access for mental health care.

International Registered Report Identifier (IRRID)
DERR1-10.2196/58890
Implementasi Roadmap Pengamanan Wilayah Perbatasan dalam Menghadapi Klaim Malaysia dan Implikasinya terhadap Ketahanan Wilayah (Studi Kasus di Perbatasan Ambalat)
Authors: Suryono Yoos 
Published: August 2024

ABSTRAK Blok Ambalat adalah sumber sengketa antara Indonesia dan Malaysia. Perselisihan muncul ketika Malaysia berusaha merebut Blok Ambalat yang diduga kaya akan sumberdaya laut dan bawah laut, terutama minyak. Perselisihan itu berasal dari penarikan sepihak perbatasan maritim Malaysia pada peta baru tahun 1979, yang memasukkan Blok Ambalat sebagai wilayahnya. Berdasarkan permasalahan tersebut, tujuan dari penelitian ini adalah mengimplementasikan strategi TNI dalam operasi pengamanan perbatasan di Blok Ambalat untuk menangkal berbagai ancaman yang berasal dari Malaysia. Pada penelitian ini menggunakan metode deskriptif kuantitatif menggunakan pendekatan Interpretative Structural Modeling dengan menggunakan variabel-variabel yang mempengaruhi peningkatan pertahanan di perbatasan ambalat, diperoleh hasil sebagai berikut. Dari model ISM yang diperoleh dalam hasil dan pembahasan, dapat disimpulkan bahwa strategi enam (Implementing the fulfilment of budget support) merupakan prioritas utama yang harus dilaksanakan sebelum variabel lain dapat berhasil diimplementasikan. Meningkatkan kualitas sumber daya manusia (strategi lima) juga penting sebelum menerapkan strategi lainnya. Strategi lainnya, seperti pembangunan pusat pengawasan dan pengendalian ALKI teknologi terkini (strategi satu), pertukaran data cerdas dan puskodal dengan sistem K4IPP antar instansi (strategi dua), peningkatan unsur kekuatan dalam ALKI II (strategi tiga), dan pengendalian ketahanan maritim nasional (P3KMN) yaitu strategi empat.
Pengaruh Budaya Populer Di Kalangan Pemuda Dan Implikasinya Terhadap Ketahanan Budaya Komunitas Etnik (Studi Tentang Korean Wave Di Komunitas Suku Mandar, Provinsi Sulawesi Barat)
Authors: Susanti Eni , Mu’min Mu’min , Mausili Dwi Rianisa , Sajidin Muhammad , Hafid Abdul 
Published: August 2024

ABSTRAKTujuan penelitian ini adalah untuk mengetahui pengaruh budaya populer di kalangan pemuda dan implikasinya terhadap ketahanan budaya komunitas etnik (studi tentang Korean Wave di Komunitas Suku Mandar Provinsi Sulawesi Barat).Penelitian ini dilakukan pada bulan Agustus 2023 di Provinsi Sulawesi Barat. Jenis penelitian ini adalah deskriptif kualitatif. Teknik pengumpulan data pada penelitian ini menggunakan teknik Forum Group Discussion (FGD), observasi dan studi pustaka. Informan dari penelitian ini adalah para pemuda yang berusia antara 16 – 30 tahun dengan kriteria informan merupakan fans Korean Wave dan bersuku asli mandar yang berdomisili di wilayah Provinsi Sulawesi Barat. Informan pada penelitian ini berjumlah 13 orang. Data yang diperoleh dianalisis secara deskriptif kualitatif.Berdasarkan hasil penelitian didapatkan bahwa masuknya kebudayaan korean wave tidak memberikan pengaruh terhadap ketahanan budaya Mandar di kalangan pemuda di Provinsi Sulawesi Barat. Informan dalam penelitian ini masih mampu menjawab pertanyaan yang berkaitan dengan kebudayaan mandar seperti kepandaian berbahasa Mandar, nilai-nilai malaqbiq, makanan khas, baju adat serta macam-macam kebudayaan yang ada di tanah Mandar. Ini membuktikan bahwa mereka tidak melupakan kebudayaannya sendiri walaupun masih terdapat beberapa informan yang tidak lancar berbahasa mandar, tidak paham mengenai nilai-nilai malaqbiq di tanah Mandar, dan sedikit kebudayaan yang masih diingat. Namun secara keseluruhan informan masih mengetahui budaya asli Mandar seiring dengan masuknya budaya korean wave, hal ini dikarenakan lingkungan sekitar seperti keluarga dan masyarakat yang masih menerapkan budaya Mandar dalam kehidupannya sehari-hari. Bahkan dengan adanya korean wave mereka lebih termotivasi dan semangat dalam mengejar impiannya. Berdasarkan hasil penelitian didapatkan bahwa masuknya kebudayaan korean wave tidak memberikan pengaruh negatif terhadap ketahanan budaya Mandar di kalangan pemuda di Provinsi Sulawesi Barat.
Kontribusi Usaha Kambing Bligon Dalam Mewujudkan Ketahanan Pangan Berbasis Ternak Wilayah (Studi di Daerah Pesisir Kabupaten Bantul, DIY)
Authors: Haryanto Bambang , Wardi Wardi , Puspito Sigit , Yano Aan Andri , Pratiwi Nugraheni Nur , Bhermana Andy , Sulistyaningsih Yoshi Tri 
Published: August 2024

ABSTRACT Bligon goats, as one of the local livestock resources, had significant potential to improved the welfare of coastal communities in Bantul Regency. The aim of the research was to analyzed the contribution of the viability of the bligon goat business in realizing food resilience, livestock empowerment, and the foundations of national resilience in the coastal areas of Bantul Regency. The research was conducted in Bantul Regency at two kapanewons which represent coastal areas, namely Sanden and Srandakan. This study used an approach to economic conditions over the past year. The calculations carried out included total production, added value, the function of livestock as savings, insurances and fertilizer producers. The average age of farmers in the research location was 53 years 10 months, with an average of 13 years of farming experience and an average of 7 goats. The results of calculating the Net Benefit-Cost Ratio (B/C), Payback Period (PP), and Internal Rate of Return (IRR) in calculating the financial feasibility of the Bligon goat farming business in coastal areas showed that this business was worthy of development. The development of Bligon goat cultivation could be used in efforts to alleviated poverty in the community and supported sustainable economic growth in the coastal areas of Bantul Regency. The sustainability of this economic dimension was expected to make a positive contribution to food resilience and national resilience by encouraging an increase in the number of farmers and goats.