bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in high on-treatment platelet reactivity between intracoronary and peripheral blood after dual anti-platelet agents in patients with coronary artery disease
Authors: Wu Cheng-Hsueh , Lin Yenn-Jiang , Chang Shih-Lin , Lo Li-Wei , Tuan Ta-Chuan , Chao Tze-Fan , Chung Fa-Po , Liao Jo-Nan , Tzeng Cheng-Hwai , Hu Yu-Feng , Lu Tse-Min , Chen Shih-Ann , Tsao Hsuan-Ming 
Published: May 2013

SummaryThe differences of high on-treatment platelet reactivity (HPR) between the coronary arteries and peripheral veins might be associated with poor prediction of adverse cardiovascular events in patients with coronary artery diseases. HPR from the peripheral blood might not adequately reflect the platelet responses in the coronary artery. A total of 21 patients were recruited, and regional differences in HPR were compared between blood samples from the intra-coronary artery (IC), femoral artery (FA), and femoral vein (FV) by light aggregometry (agonists: arachidonic acid, LTA-AA; ADP, LTA-ADP), VerifyNow P2Y12 assays, and a platelet function analyser (PFA-100, collagen and epinephrine cartridge, PFA-CEPI). There were regional differences in the platelet reactivities observed by LTA-AA, VerifyNow P2Y12 assays, and PFACEPI. Platelets from the IC had higher platelet reactivities than those from the FV and FA by the VerifyNow P2Y12 assays but lower reactivities by LTA-AA and PFA-CEPI. HPR values from the blood in the FA were more similar to those from the IC than those from the FV by any test. The monocyte percentages were the only factors associated with differences in HPR between the FV and IC by the VerifyNow P2Y12 assays. Triglyceride levels were associated with the differences in HPR between the FV and IC by LTA-ADP. During the six-month follow-up period, two patients developed cardiovascular events and exhibited differences in HPR between different sites by VerifyNow P2Y12 assays. In conclusions, there were regional differences in HPR in patients with coronary artery diseases, which might prevent the adequate prediction of cardiovascular events.
Factors associated with diagnosis and operability of chronic thromboembolic pulmonary hypertension
Authors: Simonneau Gérald , Pepke-Zaba Joanna , Mayer Eckhard , Ambrož David , Blanco Isabel , Torbicki Adam , Mellemkjaer Sören , Yaici Azzedine , Delcroix Marion , Lang Irene 
Published: May 2013

SummaryChronic thromboembolic pulmonary hypertension (CTEPH) and idiopathic pulmonary hypertension (IPAH) share a similar clinical presentation, and a differential diagnosis requires a thorough workup. Once CTEPH is confirmed, patients who can be safely operated have to be identified. We investigated risk factors associated with CTEPH and IPAH, and the criteria for the selection of operable CTEPH patients. This case-control study included 436 consecutive patients with CTEPH and 158 with IPAH in eight European centres, between 2006 and 2010. Conditions identified as risk factors for CTEPH included history of acute venous thromboembolism (p < 0.0001), large size of previous pulmonary embolism (p = 0.0040 in univariate analysis), blood groups non-O (p < 0.0001 in univariate analysis), and older age (p = 0.0198), whereas diabetes mellitus (p = 0.0006), female gender (p = 0.0197) and higher mean pulmonary artery pressure (p = 0.0103) were associated with increased likelihood for an IPAH diagnosis. Operability of CTEPH patients was associated with younger age (p = 0.0108), proximal lesions (p ≤ 0.0001), and pulmonary vascular resistance below 1200 dyn.s.cm-5 (p = 0.0080). Non-operable CTEPH patients tended to be less differentiable from IPAH patients by risk factor analysis than operable patients. This study confirmed the association of CTEPH with history of acute venous thromboembolism and blood groups non-O, and identified diabetes mellitus and higher mean pulmonary artery pressure as factors suggesting an IPAH diagnosis. Non-operable CTEPH is more similar to IPAH than operable CTEPH regarding risk factors.
Multilocus Genetic Risk Scores for Coronary Heart Disease Prediction
Authors: Ganna Andrea , Magnusson Patrik K.E. , Pedersen Nancy L. , de Faire Ulf , Reilly Marie , Ärnlöv Johan , Sundström Johan , Hamsten Anders , Ingelsson Erik 
Published: May 2013

Objective—
Current guidelines do not support the use of genetic profiles in risk assessment of coronary heart disease (CHD). However, new single nucleotide polymorphisms associated with CHD and intermediate cardiovascular traits have recently been discovered. We aimed to compare several multilocus genetic risk score (MGRS) in terms of association with CHD and to evaluate clinical use.

Approach and Results—

We investigated 6 Swedish prospective cohort studies with 10 612 participants free of CHD at baseline. We developed 1 overall MGRS based on 395 single nucleotide polymorphisms reported as being associated with cardiovascular traits, 1 CHD-specific MGRS, including 46 single nucleotide polymorphisms, and 6 trait-specific MGRS for each established CHD risk factors. Both the overall and the CHD-specific MGRS were significantly associated with CHD risk (781 incident events; hazard ratios for fourth versus first quartile, 1.54 and 1.52;
P
<0.001) and improved risk classification beyond established risk factors (net reclassification improvement, 4.2% and 4.9%;
P
=0.006 and 0.017). Discrimination improvement was modest (C-index improvement, 0.004). A polygene MGRS performed worse than the CHD-specific MGRS. We estimate that 1 additional CHD event for every 318 people screened at intermediate risk could be saved by measuring the CHD-specific genetic score in addition to the established risk factors.

Conclusions—
Our results indicate that genetic information could be of some clinical value for prediction of CHD, although further studies are needed to address aspects, such as feasibility, ethics, and cost efficiency of genetic profiling in the primary prevention setting.
Two Isoforms of Sister-of-Mammalian Grainyhead Have Opposing Functions in Endothelial Cells and In Vivo
Authors: Haendeler Judith , Mlynek Arne , Büchner Nicole , Lukosz Margarete , Graf Martin , Guettler Christopher , Jakob Sascha , Farrokh Sabrina , Kunze Kerstin , Goy Christine , Guardiola-Serrano Francisca , Schaal Heiner , Cortese-Krott Miriam , Deenen René , Köhrer Karl , Winkler Christoph , Altschmied Joachim 
Published: May 2013

Objective—
Sister-of-Mammalian Grainyhead (SOM) is a member of the Grainyhead family of transcription factors. In humans, 3 isoforms are derived from differential first exon usage and alternative splicing and differ only in their N terminal domain. SOM2, the only variant also present in mouse, induces endothelial cell migration and protects against apoptosis. The functions of the human specific isoforms SOM1 and SOM3 have not yet been investigated. Therefore we wanted to elucidate their functions in endothelial cells.

Approach and Results—
Overexpression of SOM1 in primary human endothelial cells induced migration, phosphorylation of Akt1 and endothelial nitric oxide synthase, and protected against apoptosis, whereas SOM3 had opposite effects; isoform-specific knockdowns confirmed the disparate effects on apoptosis. After reporter assays demonstrated that both are active transcription factors, microarray analyses revealed that they induce different target genes, which could explain the different cellular effects. Overexpression of SOM3 in zebrafish embryos resulted in increased lethality and severe deformations, whereas SOM1 had no deleterious effect.

Conclusions—
Our data demonstrate that the splice variant–derived isoforms SOM1 and SOM3 induce opposing effects in primary human endothelial cells and in a whole animal model, most likely through the induction of different target genes.
Common Genetic Variants of
MGP
Are Associated With Calcification on the Arterial Wall but Not With Calcification Present in the Atherosclerotic Plaques
Authors: Wang Yibo , Chen Jinxing , Zhang Yu , Yu Weifeng , Zhang Channa , Gong Ling , Shao Liying , Lu Jinguo , Gao Yang , Chen Xuannan , Chen Xi , Hui Rutai 
Published: May 2013

Background—

Two endophenotypes of arterial calcification, calcification on arterial wall and calcification in atherosclerotic plaques, are associated with different types of cardiovascular events.
Mgp
-deficient mice showed matrix Gla protein (MGP) is strongly associated with calcification on arterial wall without atherosclerotic plaques, and
MGP
variants were not significantly associated with myocardial infarction. MGP may play different roles in the 2 endophenotypes.

Methods and Results—

We analyzed the associations of
MGP
variants rs4236, rs1800801, and rs1800802 with the 2 endophenotypes determined by multidetector computed tomography angiography. A total of 585 with calcification on coronary artery wall, 675 with calcification in coronary atherosclerotic plaques, 454 with calcification on aortic wall, and 725 controls were enrolled. After Bonferroni correction, rs4236 and rs1800801 were still associated with calcification on arterial wall, the odds ratios were 0.708 (95% confidence interval, 0.540–0.928) for rs4236 and 0.652 (95% confidence interval, 0.479–0.888) for rs1800801 in coronary artery wall calcification, and 0.699 (95% confidence interval, 0.525–0.931) for rs4236 and 0.650 (95% confidence interval, 0.467–0.905) for rs1800801 in aortic wall calcification, respectively. The variants were correlated with calcification severity by ln(CAC Agatston score+1) in coronary artery wall calcification but not in atherosclerotic plaque calcification. In accordance with their associations with calcification on arterial wall, rs4236C and rs1800801A were associated with higher MGP plasma levels, whereas rs1800802C was associated with lower MGP levels in normal controls. Because of the role of calcification in plaque vulnerability, their associations with acute myocardial infarction were also determined in 771 controls and 752 patients, no association was found.

Conclusions—
MGP genetic variants showed association with calcification on arterial wall but not with calcification in atherosclerotic plaques.
Physical Fitness and Risk for Heart Failure and Coronary Artery Disease
Authors: Berry Jarett D. , Pandey Ambarish , Gao Ang , Leonard David , Farzaneh-Far Ramin , Ayers Colby , DeFina Laura , Willis Benjamin 
Published: May 2013

Background—
Multiple studies have demonstrated strong associations between cardiorespiratory fitness and lower cardiovascular disease mortality. In contrast, little is known about associations of fitness with nonfatal cardiovascular events.

Methods and Results—

Linking individual participant data from the Cooper Center Longitudinal Study with Medicare claims files, we studied 20 642 participants (21% women) with fitness measured at the mean age of 49 years and who survived to receive Medicare coverage from 1999 to 2009. Fitness was categorized into age- and sex-specific quintiles (Q) according to Balke protocol treadmill time with Q1 as low fitness. Fitness was also estimated in metabolic equivalents according to treadmill time. Associations between midlife fitness and hospitalizations for heart failure and acute myocardial infarction after the age of 65 years were assessed by applying a proportional hazards model to the multivariate failure time data. After 133 514 person-years of Medicare follow-up, we observed 1051 hospitalizations for heart failure and 832 hospitalizations for acute myocardial infarction. Compared with high fitness (Q4–5), low fitness (Q1) was associated with a higher rate of heart failure hospitalization (14.3% versus 4.2%) and hospitalization for myocardial infarction (9.7% versus 4.5%). After multivariable adjustment for baseline age, blood pressure, diabetes mellitus, body mass index, smoking status, and total cholesterol, a 1 unit greater fitness level in metabolic equivalents achieved in midlife was associated with ≈20% lower risk for heart failure hospitalization after the age of 65 years (men: hazard ratio [95% confidence intervals], 0.79 [0.75–0.83];
P
<0.001 and women: 0.81 [0.68–0.96];
P
=0.01) but just a 10% lower risk for acute myocardial infarction in men (0.91 [0.87–0.95];
P
<0.001) and no association in women (0.97 [0.83–1.13];
P
=0.68).

Conclusions—
Fitness in healthy, middle-aged adults is more strongly associated with heart failure hospitalization than acute myocardial infarction outcomes decades later in older age.
The roles of food quality and sex in chimpanzee sharing behavior (Pan troglodytes)
Authors: Tinsman Jen , Suchak Malini , Eppley Timothy M. , Campbell Matthew W. , de Waal Frans B.M. 
Published: May 2013

Both wild and captive chimpanzees (Pan troglodytes) share food with non-relatives. Researchers have proposed several hypotheses to explain this behavior, including ‘food for sex’, ‘food for grooming or agonistic support’, and ‘sharing under pressure’. We examined food sharing in two captive groups of socially-housed chimpanzees. In contrast to previous captive studies, which only examined transfers of low-quality foods, we conducted seven trials with high-quality food and seven with low-quality food for each group to directly compare transfers of different food qualities. We recorded how male chimpanzees shared food, including active transfers, passive transfers, and co-feeding. We also noted all instances of copulations, female estrous states, benign attempts to access food (termed ‘perseverance’), and aggressive attempts (termed ‘harassment’) to examine whether any of these factors influenced food sharing. Male food possessors shared at the same rate in both food quality conditions, but seemingly for different reasons, indicating that food quality may affect the exchange of social benefits in chimpanzees. In the low-quality condition, there was an interaction with rank and perseverance: while low- and middle-ranking females received more food the more they persevered, high-ranking females received more food without perseverance and gained relatively little benefit from persevering. In the high-quality condition, there was an interaction between copulations and perseverance: females who copulated with the male food possessor received more food during that trial with less perseverance. Non-copulating females received more transfers the more they persevered. This result was only observed in the short-term — copulations over the previous year were not correlated with food transfers. Further, the copulations observed here were unusual for these chimpanzees in that they were not confined to peak fertility, suggesting a non-conceptive function for copulations in chimpanzees. Copulations in this study may have functioned to reduce tension and increase short-term tolerance, allowing females better access to food.
Effects of a plant extract-based nematicide (G8014S) and its components on the host finding behaviour and multiplication of Globodera pallida on glasshouse-grown potatoes
Authors: Danquah Wiseborn B. , Grove Ivan G. , Back Matthew A. , Haydock Patrick P.J. 
Published: May 2013

In vitro and glasshouse studies were initiated to determine the mechanisms of action of an aqueous garlic extract, salicylaldehyde, a nonylphenol ethoxylate surfactant and a formulation (G8014S) containing these substances on the potato cyst nematode Globodera pallida. The effects of these substances on host finding and migration of second-stage juveniles (J2) were assessed by investigating their ability to migrate through a sand column and towards potato roots in Pluronic F-127 gel. The garlic extract was shown to be the least disruptive to J2 host finding, reducing attraction by between 13 and 24% at concentrations of 7840 μl l−1 and 983 μl l−1, respectively. By contrast, a reduction of approximately 38% in J2 attraction to roots was achieved by treating J2 with 344 μl l−1 of G8014S. Of all the substances tested, salicylaldehyde was the least attractive to G. pallida J2 (4.1%) while the garlic extract and oxamyl treatments attracted 43.5 and 28.9% J2, respectively. In glasshouse experiments, different rates of the test substances were compared with the nematicide oxamyl for their effects on the in-soil hatch, egg viability and multiplication of G. pallida. The effect of treatment with 220.16 l ha−1 of G8014S on G. pallida multiplication in the glasshouse was comparable to that of oxamyl causing a five-fold reduction in PCN multiplication relative to the water control. These results provide evidence to support the potential of the formulation for the control of G. pallida in potatoes.
The Near Eastern Chaoskampf in the River Battle of Iliad 21
Authors: Kitts Margo 
Published: May 2013

Abstract
This essay explores the river battle of Iliad 21 in terms of the Near Eastern mythological motif known as the Chaoskampf, wherein an order-promoting storm deity prevails over a water deity associated with chaos. The first section outlines four notable features of the protean Chaoskampf traditions in ancient Near Eastern literature, from Mesopotamia to the Levant to Anatolia. The second section traces these four features into the Iliad’s river battle and explains their presence by proposing cross-traditional mythopoesis, confluent with other cultural exchanges as established in recent decades. Understanding this part of the Iliad as influenced by West Asian traditions will help to explain why it is Hephaistos, not storm god Zeus, who unleashes his fire upon the menacing river god. The role of Hephaistos is examined against the roles of Ugaritic Kothar-wa-Hasis and Hittite-Hurrian Ea in their respective Chaoskampf myths.
Faith Development, Religious Styles and Biographical Narratives: Methodological Perspectives
Authors: Keller Barbara , Streib Heinz 
Published: May 2013

Abstract
Narrative study of religious lives has formed part of numerous projects at the Bielefeld Research Center for Biographical Studies in Contemporary Religion. An essential instrument in our designs, which mostly combine qualitative and quantitative methods, is the Faith Development Interview (FDI). In response to longstanding criticism its cognitive structural framework has been revised in respect of styles and schemata. The religious styles perspective examines the self as articulated in narratives and associates it with affectivity and emotion. This article gives an overview of our theoretical and methodological revisions, which take cognizance of current developments in lifespan developmental and clinical psychology such as attachment, mentalization and wisdom. We illustrate the implementation of these advances with a case study from our current study of ‘spirituality’,1 which we locate in the complex multi-method design, and outline the triangulation of qualitative and quantitative data.
The Imprint of the Imprints: Sojourners, Xiaoshuo Translations, and the Transcultural Canon of Early Chinese Fiction in Europe, 1697-1826
Authors: Sieber Patricia 
Published: May 2013

Abstract
This paper posits that the circulation of the earliest items of Chinese fiction in early modern Europe was indebted to the popularity of certain titles within the Qing-dynasty book market on the one hand and to the participation of educated Chinese in the process of purchase, selection, and translation on the other. It further argues that European translations deployed specific features of Chinese imprints in order to differentiate translations from the hugely popular pseudo-Chinese transcreations, thereby seeking to establish textual authority for a philologically grounded Chinese voice. The paper terms this convergence of conceptual, material, and social factors in producing transculturally mediated texts “biblioglossia,” in order to capture aspects of textuality neglected or obscured in standard discussions of “orientalism.”
Magnetic resonance imaging features of pathologically proven cerebral sparganosis
Authors: Chu Shuguang , Lu Xingsui , Wang Yin , Gao Gejun , Xv Feijia , Zee Chi-Shing , Yao Zhenwei 
Published: May 2013

Objective The purpose of this study was to identify characteristic magnetic resonance imaging (MRI) features of cerebral sparganosis, a rare parasitic disease caused by the plerocercoid larva of Spirometra mansoni. Methods This retrospective study reviewed medical records, computed tomography (CT) and MRI scans and pathological specimens from patients with pathologically proven cerebral sparganosis. The location, signal intensity and contrast enhancement characteristics of the lesions were assessed. Results Records of 12 patients (seven male and five female; age range 8–35 years) were reviewed. A total of 13 lesions were identified: of the 10 patients with supratentorial lesions, nine had a single lesion and one had bilateral hemispheric lesions. Two patients had a single lesion in the ependyma of the 4th ventricle. All lesions were iso-hypointense on T1-weighted images, slightly hypointense on T2-weighted images and surrounded by extensive oedema. Ten of the 13 lesions demonstrated a ‘string-knots sign’, characterized by a tangled string in a knot-like shape on contrast-enhanced MRI. Conclusion A string-knots sign enhancement pattern in cortical–subcortical regions should suggest the diagnosis of cerebral sparganosis.
Temporomandibular dysfunction syndrome: A prospective study of 255 consecutive patients
Authors: Uçar Demet , Dıraçoğlu Demirhan , Karan Ayşe 
Published: May 2013

Objective To determine the relationship between temporomandibular dysfunction syndrome (TMDS), sex and pain severity. Methods Data were collected prospectively from consecutive patients with TMDS. Patients were divided into four subgroups according to signs and symptoms: myofascial pain; intra-articular disorders; extra-articular disorders; degenerative disorders. Intergroup sex distribution differences were evaluated, the pain severity between the four subgroups was compared, and the rates of bruxism and inco-ordination were measured. A visual analogue scale was used to rate the pain. Results A total of 255 patients with TMDS were included in the study. A significantly higher rate of extra-articular disorders was found in male patients. Bruxism was found to be significantly more common in females than in males. There was no significant difference in the prevalence of inco-ordination based on sex. The overall pain score was higher in females than in males, but there was no significant difference. The pain score was significantly higher in patients in the degenerative disorders subgroup, compared with other subgroups. Conclusions There was no relationship between TMDS and pain and sex. Pain scores were significantly higher in the degenerative disorders subgroup, compared with other subgroups.