bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer Recovery Analysis System
Authors: Balasubramanian Priya , Pradeep Archana , Dileepkumar Deepak , Farris John P. , Jack Hugh 
Published: March 2015

Breast cancer is one of the most common types of cancer among women with over 230,000 incidences diagnosed every year. A typical breast cancer surgery might include but is not limited to, biopsies, breast conservation surgery or mastectomies. Moreover, these surgeries usually cause soreness in the shoulder and arms which in turn affect the ability of the patient to perform simple everyday activities.
Lymphedema, another serious side effect of these surgeries, when coupled with radiation therapy, can appear in breast cancer patients during months or even years after the treatment ends. Lymphedema is a condition in which high-protein fluid collects beneath the skin and causes swelling, redness and discomfort. This condition occurs in breast cancer patients when lymph nodes are damaged or removed during the procedures.
Research suggests that early physiotherapy as well as exercises can reduce the risk of lymphedema. Monitoring the progress during these exercises can be a first step in diagnosing lymphedema. Along with better prognosis, the patients can observe the benefits of early diagnosis with insurance coverage, since most insurance companies do not cover treatments associated with advanced stages of lymphedema. The initial stretching workouts, done during recovery, target the range of motion of the shoulder that is affected by the surgery. This range of motion, determined by the severity of the surgery, improves over time. These exercises can then be used to drain the lymph nodes and help retain flexibility in the affected muscles. A monitoring device engineered to provide data about the extent of recovery would be a significant aide to both the patients and healthcare professionals.
The intent of the paper is to introduce a distinctive device that monitors workouts and uses the data as a motivating factor for the patient as well as an early detection system for lymphedema. The device shows the effort that the patient has put for each workout into user friendly real time graphs. Patients and healthcare professionals can then use this data and graphs to identify problem areas in the recovery process. Preliminary tests of this device, which are presented in this paper, showed promising results in accuracy and repeatability as the device calculated and displayed graphs which were a quantified estimation of the range of motion and workout effort of the user.
Head phantoms for transcranial focused ultrasound
Authors: Eames Matthew D. C. , Farnum Mercy , Khaled Mohamad , Jeff Elias W. , Hananel Arik , Snell John W. , Kassell Neal F. , Aubry Jean‐Francois 
Published: March 2015

Purpose:In the ongoing endeavor of fine‐tuning, the clinical application of transcranial MR‐guided focused ultrasound (tcMRgFUS), ex‐vivo studies wlkiith whole human skulls are of great use in improving the underlying technology guiding the accurate and precise thermal ablation of clinically relevant targets in the human skull. Described here are the designs, methods for fabrication, and notes on utility of three different ultrasound phantoms to be used for brain focused ultrasound research.Methods:Three different models of phantoms are developed and tested to be accurate, repeatable experimental options to provide means to further this research. The three models are a cadaver, a gel‐filled skull, and a head mold containing a skull and filled with gel that mimics the brain and the skin. Each was positioned in a clinical tcMRgFUS system and sonicated at 1100 W (acoustic) for 12 s at different locations. Maximum temperature rise as measured by MR thermometry was recorded and compared against clinical data for a similar neurosurgical target. Results are presented as heating efficiency in units (°C/kW/s) for direct comparison to available clinical data. The procedure for casting thermal phantom material is presented. The utility of each phantom model is discussed in the context of various tcMRgFUS research areas.Results:The cadaveric phantom model, gel‐filled skull model, and full head phantom model had heating efficiencies of 5.3, 4.0, and 3.9 °C/(kW/s), respectively, compared to a sample clinical heating efficiency of 2.6 °C/(kW/s). In the seven research categories considered, the cadaveric phantom model was the most versatile, though less practical compared to the ex‐vivo skull‐based phantoms.Conclusions:Casting thermal phantom material was shown to be an effective way to prepare tissue‐mimicking material for the phantoms presented. The phantom models presented are all useful in tcMRgFUS research, though some are better suited to a limited subset of applications depending on the researchers needs.
Draft Genome Sequence of Halomonas sp. KHS3, a Polyaromatic Hydrocarbon-Chemotactic Strain
Authors: Gasperotti Ana Florencia , Studdert Claudia Alicia , Revale Santiago , Herrera Seitz María Karina 
Published: March 2015

ABSTRACT
The draft genome sequence of Halomonas sp. KHS3, isolated from seawater from Mar del Plata harbor, is reported. This strain is able to grow using aromatic compounds as a carbon source and shows strong chemotactic response toward these substrates. Genes involved in motility, chemotaxis, and degradation of aromatic hydrocarbons were identified.
Two Complete and One Draft Genome Sequence of Nonproteolytic Clostridium botulinum Type E Strains NCTC 8266, NCTC 8550, and NCTC 11219
Authors: Clauwers Charlien , Briers Yves , Lavigne Rob , Michiels Chris W. 
Published: March 2015

ABSTRACT

Group II (gII) nonproteolytic
Clostridium botulinum
strains are a major cause of foodborne botulism outbreaks. Here, we report two complete genome sequences of gII type E strains NCTC 8266 and NCTC 8550 and one draft genome sequence of type E NCTC 11219.
Draft Genome Sequences of Two Strains of Serratia spp. from the Midgut of the Malaria Mosquito Anopheles gambiae
Authors: Pei Dong , Hill-Clemons Casey , Carissimo Guillaume , Yu Wanqin , Vernick Kenneth D. , Xu Jiannong 
Published: March 2015

ABSTRACT

Here, we report the annotated draft genome sequences of two strains of Serratia spp., Ag1 and Ag2, isolated from the midgut of two different strains of
Anopheles gambiae
. The genomes of these two strains are almost identical.
Genome Sequences of Mannheimia haemolytica Serotype A2 Isolates D171 and D35, Recovered from Bovine Pneumonia
Authors: Hauglund Melissa J. , Tatum Fred M. , Bayles Darrell O. , Maheswaran Samuel K. , Briggs Robert E. 
Published: March 2015

ABSTRACT

Here, we report two genomes, one complete and one draft, from isolates of serotype A2
Mannheimia haemolytica
recovered from pneumonic bovine lung.
Complete Genomic Sequence for an Avian Group G Rotavirus from South Africa
Authors: Stucker Karla M. , Stockwell Timothy B. , Nyaga Martin M. , Halpin Rebecca A. , Fedorova Nadia , Akopov Asmik , Ngoveni Harry , Peenze Ina , Seheri Mapaseka L. , Mphahlele M. Jeffrey , Wentworth David E. 
Published: March 2015

ABSTRACT
We report the first complete sequence for an avian group G rotavirus (RVG) genome from Africa, which is the third publically available RVG genome. These RVG genomes are highly diverse, especially in their VP4, VP7, NSP4, and NSP3 segments, indicating that RVG diversity is comparable to that of rotavirus A.
Complete Genome Sequence of Mycoplasma flocculare Strain Ms42
T
(ATCC 27399
T
)
Authors: Calcutt Michael J. , Foecking Mark F. , Heidari Manijeh B. , McIntosh Mark A. 
Published: March 2015

ABSTRACT

Mycoplasma flocculare
is a commensal or low-virulence pathogen of swine. The complete 778,866-bp genome sequence of M. flocculare strain Ms42
T
has been determined, enabling further comparison to genomes of the closely related pathogen
Mycoplasma hyopneumoniae
. The absence of the
p97
and
glpD
genes may contribute to the attenuated virulence of M. flocculare.
Complete Genome Sequences of Influenza A/H1N1 Strains Isolated from Patients during the 2013-2014 Epidemic Season in Finland
Authors: Jalovaara Petri , Mishel Polina , Kallio-Kokko Hannimari , Valkonen Miia , Kantele Anu , Ikonen Niina , Julkunen Ilkka , Kakkola Laura , Kutsaya Anna , Vuorinen Tytti , Mattila Pirkko , Almusa Henrikki , Kainov Denis 
Published: March 2015

ABSTRACT
Here, we report 40 complete genome sequences of influenza A/H1N1 strains isolated from 33 nonhospitalized and 7 hospitalized patients during the 2013-2014 epidemic season in Finland. An analysis of the aligned sequences revealed no oseltamivir-resistant genotypes. As a whole, the recent viruses have drifted from the prototype A/California/7/2009 virus by ca. 1.3%.
Draft Genome Sequences of Five Spore-Forming Food Isolates of Bacillus pumilus
Authors: de Jong Anne , van Heel Auke J. , Montalban-Lopez Manuel , Krawczyk Antonina O. , Berendsen Erwin M. , Wells-Bennik Marjon , Kuipers Oscar P. 
Published: March 2015

ABSTRACT

Here, we report the draft genome sequences of five food isolates of
Bacillus pumilus
, a spore-forming Gram-positive bacterium.
Details behind the dots: How different intensive care units used common and contrasting methods to prevent ventilator associated pneumonia
Authors: Daniel Malcolm , Booth Malcolm , Ellis Kirsteen , Maher Shaun , Longmate Andrew 
Published: March 2015

AbstractCare bundles promote delivery of effective care and improve patient outcomes. The understanding of how to improve delivery of care bundles is incomplete.The Scottish Patient Safety Programme is a national collaborative with the aim of improving the delivery of care to patients in acute hospitals in Scotland. Critical care is one of five workstreams in the programme. A programme goal is to reduce incidence of ventilator-associated pneumonia (VAP) to zero or 300 calendar days between events through use of a VAP Prevention bundle. We studied two ICUs participating in this programme. Each ICU had established infection surveillance system prior to the programme starting. Both units had an appreciable incidence of VAP. Initial VAP prevention bundle adherence was low in each ICU (35% and 41%).Comparing time periods before and after 80% bundle VAP prevention bundle adherence was achieved showed a similar reduction in VAP incidence (from 6.9 to 1.0, and from 7.8 to 1.4/1000 ventilation days). When compared each ICU used common and contrasting approaches to accomplish this improvement.We describe the five improvement knowledge systems used to improve bundle adherence to bundle elements in each hospital. The insights gained from these front-line clinical teams can be used as a template for improvement efforts in a variety of other healthcare settings.
Association of a lifestyle index with MRI-determined liver fat content in a general population study
Authors: Koch Manja , Borggrefe Jan , Schlesinger Sabrina , Barbaresko Janett , Groth Godo , Jacobs Gunnar , Lieb Wolfgang , Laudes Matthias , Müller Manfred J , Bosy-Westphal Anja , Heller Martin , Nöthlings Ute 
Published: March 2015

BackgroundIn prior studies, lifestyle indices were associated with numerous disease end points, but the association with fatty liver disease (FLD), a key correlate of cardiometabolic risk, is unknown. The aim was to investigate associations between a lifestyle index with liver fat content.MethodsLiver fat was quantified by MRI as liver signal intensity (LSI) in 354 individuals selected from a population-based cohort from Germany. Exposure to favourable lifestyle factors was quantified using an additive score with each factor modelled as a dichotomous trait. Favourable lifestyle factors were defined as waist circumference below 102 (men) or 88 cm (women), physical activity ≥3.5 h/week, never-smoking and a favourable dietary pattern, which was derived to explain liver fat variation. In a cross-sectional study, multivariable adjusted linear and logistic regression was applied to investigate the association between the lifestyle index (range 0–4, exposure) and LSI (modelled as a continuous trait or dichotomised as a FLD indicator variable, respectively).ResultsIndividuals with four favourable lifestyle factors (n=9%) had lower LSI values (ß −0.40; 95% CI −0.61 to −0.19) and a lower OR (0.09; 95% CI 0.03 to 0.30) for FLD compared with individuals with zero favourable lifestyle factors (n=10%).ConclusionsA healthy lifestyle pattern was associated with less liver fat. Prospective studies are warranted.
Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-cell Malignancies
Authors: Bachanova Veronika , Frankel Arthur E. , Cao Qing , Lewis Dixie , Grzywacz Bartosz , Verneris Michael R. , Ustun Celalettin , Lazaryan Aleksandr , McClune Brian , Warlick Erica D. , Kantarjian Hagop , Weisdorf Daniel J. , Miller Jeffrey S. , Vallera Daniel A. 
Published: March 2015

Abstract
Purpose: The novel bispecific ligand-directed toxin (BLT) DT2219 consists of a recombinant fusion between the catalytic and translocation enhancing domain of diphtheria toxin (DT) and bispecific single-chain variable fragments (scFV) of antibodies targeting human CD19 and CD22. We conducted a phase I dose-escalation study to assess the safety, maximum tolerated dose, and preliminary efficacy of DT2219 in patients with relapsed/refractory B-cell lymphoma or leukemia.
Experimental Design: DT2219 was administered intravenously over 2 hours every other day for 4 total doses. Dose was escalated from 0.5 μg/kg/day to 80 μg/kg/day in nine dose cohorts until a dose-limiting toxicity (DLT) was observed.
Results: Twenty-five patients with mature or precursor B-cell lymphoid malignancies expressing CD19 and/or CD22 enrolled to the study. Patients received median 3 prior lines of chemotherapy and 8 failed hematopoietic transplantation. All patients received a single course of DT2219; one patient was retreated. The most common adverse events, including weight gain, low albumin, transaminitis, and fever were transient grade 1–2 and occurred in patients in higher dose cohorts (≥40 μg/kg/day). Two subjects experienced DLT at dose levels 40 and 60 μg/kg. Durable objective responses occurred in 2 patients; one was complete remission after 2 cycles. Correlative studies showed a surprisingly low incidence of neutralizing antibody (30%).
Conclusions: We have determined the safety of a novel immunotoxin DT2219 and established its biologically active dose between 40 and 80 μg/kg/day ×4. A phase II study exploring repetitive courses of DT2219 is planned. Clin Cancer Res; 21(6); 1267–72. ©2015 AACR.
Absence of Four-and-a-Half LIM Domain Protein 2 Decreases Atherosclerosis in ApoE
−/−
Mice
Authors: Ebrahimian Talin , Simon David , Lemarié Catherine A. , Simeone Stefania , Heidari Maryam , Mann Koren K. , Wassmann Sven , Lehoux Stephanie 
Published: March 2015

Objective—
Four-and-a-half LIM domain protein-2 (FHL2) is expressed in endothelial cells, vascular smooth muscle cells, and leukocytes. It regulates cell survival, migration, and inflammatory response, but its role in atherogenesis is unknown.

Approach and Results—
To investigate the role of FHL2 in atherosclerosis, FHL2-deficient mice were crossed with ApoE-deficient mice, to generate ApoE/FHL2−/− mice. After high-fat diet, ApoE/FHL2−/− mice had significantly smaller atherosclerotic plaques than ApoE−/− mice in the aortic sinus, the brachiocephalic artery, and the aorta. This was associated with enhanced collagen and smooth muscle cell contents and a 2-fold reduction in macrophage content within the plaques of ApoE/FHL-2−/− versus ApoE−/− mice. This could be explained, in part, by the reduction in aortic ICAM-1 (intracellular adhesion molecule) mRNA and VCAM-1 (vascular cell adhesion molecule) protein expression in the plaque. Aortic gene expression of the chemokines CX3CL1 and CCL5 was increased in ApoE/FHL2−/− versus ApoE−/− mice. Peritoneal thioglycollate injection elicited equivalent numbers of monocytes and macrophages in both groups, but a significantly lower number of proinflammatory Ly6C high monocytes were recruited in ApoE/FHL2−/− versus ApoE−/− mice. Furthermore, mRNA levels of CX3CR1 were 2-fold higher in monocytes from ApoE/FHL2−/− versus ApoE−/− mice. Finally, we investigated the potential importance of myeloid cell FHL2 deficiency in atherosclerosis. After being irradiated, ApoE−/− or ApoE/FHL2−/− mice were transplanted with ApoE−/− or ApoE/FHL2−/− bone marrow. After high-fat diet, both chimeric groups developed smaller plaques than ApoE−/− transplanted with ApoE−/− bone marrow.

Conclusions—
These results suggest that FHL2 in both myeloid and vascular cells may play an important role in atherosclerosis by promoting proinflammatory chemokine production, adhesion molecule expression, and proinflammatory monocyte recruitment.
Infarct Volume-Based Subgroup Selection in Acute Ischemic Stroke Trials
Authors: Kufner Anna , Wouters Anke , Bracoud Luc , Laage Rico , Schneider Armin , Schäbitz Wolf-Rüdiger , Hermier Marc , Thijs Vincent , Fiebach Jochen B. 
Published: March 2015

Background and Purpose—
We investigated whether hyperintensities with a diameter of at least 3, 3.5, and 4 cm and visible on at least 3 slices on diffusion-weighted imaging enables patient selection with an infarct volume of ≥15 mL.

Methods—
Consecutive acute stroke patients were screened for the AXIS2 trial and examined according to a standardized magnetic resonance imaging protocol in 65 sites. Diffusion-weighted lesion diameters were measured and compared with volumetric assessments.

Results—
Out of 238 patients, 86.2% (N=206) had infarct diameter of at least 3 cm. Volumetric assessments showed infarct volume of ≥15 mL in 157 patients. A cut-off value of 3 cm led to 96.8% sensitivity and 33.3% specificity for predicting lesion volume of ≥15 mL. Analogously, a 3.5 cm cut-off led to 96.8% sensitivity and 50.6% specificity and a 4 cm cut-off led to 91.7% sensitivity and 61.7% specificity.

Conclusions—
Lesion diameter measures may enable multicentric patient recruitment with a prespecified minimal infarct volume.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00927836.
B-Type Natriuretic Peptides Help in Cardioembolic Stroke Diagnosis
Authors: Llombart Víctor , Antolin-Fontes Albert , Bustamante Alejandro , Giralt Dolors , Rost Natalia S. , Furie Karen , Shibazaki Kensaku , Biteker Murat , Castillo José , Rodríguez-Yáñez Manuel , Fonseca Ana Catarina , Watanabe Tetsu , Purroy Francisco , Zhixin Wu , Etgen Thorleif , Hosomi Naohisa , Jafarian Kerman Scott Reza , Sharma Jagdish C. , Knauer Carolin , Santamarina Estevo , Giannakoulas George , García-Berrocoso Teresa , Montaner Joan 
Published: March 2015

Background and Purpose—
Determining the underlying cause of stroke is important to optimize secondary prevention treatment. Increased blood levels of natriuretic peptides (B-type natriuretic peptide/N-terminal pro-BNP [BNP/NT-proBNP]) have been repeatedly associated with cardioembolic stroke. Here, we evaluate their clinical value as pathogenic biomarkers for stroke through a literature systematic review and individual participants’ data meta-analysis.

Methods—
We searched publications in PubMed database until November 2013 that compared BNP and NT-proBNP circulating levels among stroke causes. Standardized individual participants’ data were collected to estimate predictive values of BNP/NT-proBNP for cardioembolic stroke. Dichotomized BNP/NT-proBNP levels were included in logistic regression models together with clinical variables to assess the sensitivity and specificity to identify cardioembolic strokes and the additional value of biomarkers using area under the curve and integrated discrimination improvement index.

Results—
From 23 selected articles, we collected information of 2834 patients with a defined cause. BNP/NT-proBNP levels were significantly elevated in cardioembolic stroke until 72 hours from symptoms onset. Predictive models showed a sensitivity >90% and specificity >80% when BNP/NT-proBNP were added considering the lowest and the highest quartile, respectively. Both peptides also increased significantly the area under the curve and integrated discrimination improvement index compared with clinical models. Sensitivity, specificity, and precision of the models were validated in 197 patients with initially undetermined stroke with final pathogenic diagnosis after ancillary follow-up.

Conclusions—
Natriuretic peptides are strongly increased in cardioembolic strokes. Future multicentre prospective studies comparing BNP and NT-proBNP might aid in finding the optimal biomarker, the best time point, and the optimal cutoff points for cardioembolic stroke identification.
Systolic Blood Pressure and Mortality After Stroke
Authors: Lin Michelle P. , Ovbiagele Bruce , Markovic Daniela , Towfighi Amytis 
Published: March 2015

Background and Purpose—
Recent studies suggest a J-shaped association between systolic blood pressure (SBP) and cardiovascular events. The optimal SBP target after stroke remains unknown. We assessed the link between SBP and mortality after stroke.

Methods—
We included adults (≥20 years) with self-reported stroke who participated in the National Health and Nutrition Examination Surveys 1998 to 2004, with mortality assessment in 2006. Baseline SBP was categorized as low to normal (<120 mm Hg), normal (120–140 mm Hg), and high (≥140 mm Hg). Independent relationships between baseline SBP and all-cause and vascular mortality were assessed using Cox proportional hazards.

Results—

Of 31 126 adult participants, 455 had self-reported stroke and baseline BP readings: 19% had low to normal, 31% had normal, and 50% had high SBP. Two years after assessment, the low to normal SBP group tended to have the highest cumulative all-cause mortality (11.5%), compared with mortality rates of 8.5% and 7.5% in the normal and high SBP groups, respectively. Similar patterns were seen with vascular mortality. After adjusting for covariates, compared with the high SBP group, the low to normal group had higher all-cause mortality (adjusted hazard ratio, 1.96; 95% confidence interval, 1.13–3.39;
P
=0.017) and trended toward higher vascular mortality (adjusted hazard ratio, 2.08; 95% confidence interval, 0.93–4.68;
P
=0.075). Compared with the normal BP group, the risk of all-cause and vascular mortality trended higher in low to normal BP group but did not achieve statistical significance.

Conclusions—
After stroke, compared with SBP in the high range, low to normal SBP is associated with poorer mortality outcomes.
Motivations for Bilateral Aid Allocation in Korea: Humanitarian, Commercial, or Diplomatic?
Authors: Park Bokyeong , Lee Hongshik 
Published: March 2015

This study investigates Korea's motivations for foreign aid allocation, analyzing panel data from over 180 countries for the last 20 years. The results show that Korea's aid allocation reflects both recipient needs and Korea's own national interests but does not consistently consider aid effectiveness. Korean aid is also characterized by its use as an instrument of both summit diplomacy and resource security. In addition, its commercial motivations appear to have shifted over time, from export promotion to overseas investment support. Despite internal and external pressures, there is no obvious evidence that Korea's allocation rule converges with international guidelines that recommend greater consideration of recipient needs and aid effectiveness and less consideration of donor interests.