bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Organotrifluoroborate for Broadly Applicable One‐Step 18F‐Labeling
Authors: Liu Zhibo , Pourghiasian Maral , Radtke Mark Alex , Lau Joseph , Pan Jinhe , Dias Gemma M. , Yapp Donald , Lin Kuo‐Shyan , Bénard Francois , Perrin David M. 
Published: September 2014

AbstractA new zwitterionic organotrifluoroborate is appended to three radiosynthons that afford undergo facile bioconjugation to several clinically relevant peptides and one enzyme inhibitor. Molecularly complex bioconjugates are 18F‐labeled in a single aqueous step in rapid time (<15 min) without HPLC purification to afford tracers in good yields (>200 mCi, 20–40 %) at high specific activity (≥3 Ci/μmol) and at >98 % purity. PET imaging shows in vivo stability and tumor uptake.
Synthesis of Aryldiazoacetates through Palladium(0)‐Catalyzed Deacylative Cross‐Coupling of Aryl Iodides with Acyldiazoacetates
Authors: Ye Fei , Wang Chengpeng , Zhang Yan , Wang Jianbo 
Published: September 2014

AbstractPalladium(0)‐catalyzed deacylative cross‐coupling of aryl iodides and acyldiazocarbonyl compounds can be achieved at room temperature under mild reaction conditions. The coupling reaction represents a highly efficient and general method for the synthesis of aryldiazocarbonyl compounds, which have found wide and increasing applications as precursors for generating donor/acceptor‐substituted metallocarbenes.
The Many Faces of Soot: Characterization of Soot Nanoparticles Produced by Engines
Authors: Niessner Reinhard 
Published: September 2014

AbstractSoot nanoparticles produced by engines constitute a threat to human health. For the analytical chemist, soot is a hard nut to crack as the released particles undergo rapid changes in their size, shape, and number concentration. The complete characterization of soot will be essential to meet future low‐emission standards. Besides measuring the light extinction, modern analytical chemistry can determine a variety of less‐known effects, such as condensation properties, immune response in vertebrates, and impact on the cardiovascular function of a beating heart. Photon emission and in particular Raman spectroscopy provides information on the nanocrystallinity, while thermoelectron emission allows the number of electrical particles to be counted. Even the “simple” combustion of soot nanoparticles offers potential for the characterization of the particles.
Soft Magnets from the Self‐Organization of Magnetic Nanoparticles in Twisted Liquid Crystals
Authors: Matt Benjamin , Pondman Kirsten M. , Asshoff Sarah J. , ten Haken Bennie , Fleury Benoit , Katsonis Nathalie 
Published: September 2014

AbstractOrganizing magnetic nanoparticles into long‐range and dynamic assemblies would not only provide new insights into physical phenomena but also open opportunities for a wide spectrum of applications. In particular, a major challenge consists of the development of nanoparticle‐based materials for which the remnant magnetization and coercive field can be controlled at room temperature. Our approach consists of promoting the self‐organization of magnetic nanoparticles in liquid crystals (LCs). Using liquid crystals as organizing templates allows us to envision the design of tunable self‐assemblies of magnetic nanoparticles, because liquid crystals are known to reorganize under a variety of external stimuli. Herein, we show that twisted liquid crystals can be used as efficient anisotropic templates for superparamagnetic nanoparticles and demonstrate the formation of hybrid soft magnets at room temperature.
Simulation and analysis of multiple steady states in dividing wall column
Authors: Wang Erqiang 
Published: September 2014

AbstractThis paper presents simulation and analysis of multiple steady states (MSS) in dividing wall column (DWC). First steady state simulation of benzene–toluene–xylene (BTX) separation in DWC is run to obtain its four different solutions using Aspen Plus software, and then detailed comparisons and analysis of these solutions are carried out. From simulation results, it can be concluded that MSS inevitably exists in DWC, which is important for its design, operation and control but has not been declared in open literature up to now. In addition, obvious grouping feature is found among the four solutions of BTX DWC case, and light component benzene and heavy component xylene have, respectively, two different recoveries at the top of the side column among the four solutions. The grouping feature is interesting and important for DWC, which may be explained by the existence of impurities in side product stream and their different flow paths from the feed to the side product stream, that is, above or under the dividing wall. © 2014 Curtin University of Technology and John Wiley & Sons, Ltd.
Viscoelastic behavior of hybrid building materials
Authors: Papanicolaou George Christopher , Lagas Georgios P. , Zaoutsos Stefanos Polymeros 
Published: September 2014

ABSTRACTThe objective of this experimental work is the investigation of the viscoelastic behavior of a hybrid matrix, fiber‐reinforced building material. Hybrid matrix consisted of epoxy resin mixed with fine marble sand, whereas short steel fibers were used as reinforcement. The experimental procedure involved, first, the manufacturing of specimens using different hybrid matrix types and different reinforcement by weight ratios. Subsequently, bending relaxation experiments at room temperature were executed, under three‐point bending test experimental configuration, at different strain levels and the variation of stress of the hybrid matrix material with time was monitored. The data obtained were used to (i) investigate the effect of reinforcement mass fraction contained in the composite on the viscoelastic behavior and (ii) to apply existed and newly developed viscoelastic models for the description of the observed viscoelastic behavior. More precisely, the four‐parameter (Burgers) viscoelastic model and the modified Residual Property Model were calibrated and used to simulate the relaxation behavior of the materials manufactured and tested. Experimental results exhibited a clear influence of both reinforcement ratio and initial displacement on the viscoelastic behavior of the materials manufactured and tested, whereas the models proposed and used can adequately reproduce the variation of relaxation stress with time. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41429.
Output Feedback Stabilization for a Class of Stochastic High‐Order Feedforward Nonlinear Systems with Time‐Varying Delay
Authors: Ai Weiqing , Zhai Junyong , Fei Shumin 
Published: September 2014

AbstractThis paper considers the output feedback control problem for a class of stochastic high‐order feedforward nonlinear systems with time‐varying delay. Compared with existing works, the features of our system include different bounded time‐varying delays, more general high‐order power and homogeneous feedforward growth conditions. Firstly, we use the adding one power integrator technique to construct an output feedback controller without nonlinearities. Then, by introducing a scaling gain into the controller and choosing an appropriate Lyapunov–Krasovskii functional, the closed‐loop system can be rendered globally asymptotically stable in probability. A simulation example is provided to illustrate the effectiveness of the designed controller.
The Sharing Dilemma: Joining Cooperative Groups and Sharing Resources as a Means of Coping with Environmental Risk
Authors: Suleiman Ramzi , Aharonov‐Majar Efrat , Luzon Pini 
Published: September 2014

ABSTRACTThe “social insurance” hypothesis posits that individuals join cooperative groups and share resources in order to reduce environmental risk. Despite its significance for explaining cooperative groups' formation, in small‐scale and in developing societies, the hypothesis has been subjected to little experimental testing. The present research is designed to examine the relative weight of the motivation for social insurance compared with other psychological motivations for sharing risk. We conducted two studies to test the tendency to share risk under different risk conditions and for groups of different sizes. A third experiment extends the risk‐sharing research to situations involving losses instead of gains. The findings of the first two studies lend strong support to the risk‐sharing hypothesis in the gain domain. For the loss domain, the results of the third experiment demonstrate an intriguing shift from strong reluctance to join groups under lower risk, to ubiquitous readiness to join groups under higher risk. We discuss these results in light of prospect theory and decisions from experience. Copyright © 2014 John Wiley & Sons, Ltd.
Bladder exstrophy–epispadias complex and triple‐X syndrome: Incidental finding or causality?
Authors: Ramaekers Paul , Loeys Bart , von Lowtzow Catharina , Reutter Heiko , Leroy Yves , Colpaert Cécile , Blaumeiser Bettina , Janssens Katrien , Parizel Maxim , Jacquemyn Yves 
Published: September 2014

BackgroundBladder exstrophy is a rare malformation. Prenatal diagnosis is usually an incidental finding on routine ultrasound examination. Triple‐X syndrome (karyotype 47,XXX) is the most frequent sex chromosome aneuploidy in live‐born females (approximately 1 in 1000). The diagnosis is often not made because women with 47,XXX karyotype have no or hardly any clinical symptoms during life.MethodsPrenatal diagnosis of triple X karyotype is usually an incidental finding when an invasive prenatal diagnosis is performed for other reasons.ResultsHere, we report on two cases with bladder exstrophy and triple‐X syndrome, one in a fetus and one in an adult. In view of two previous reports of this association in literature, causality of these two conditions should be considered.ConclusionA gene dosage effect as possible underlying mechanisms will be discussed. Birth Defects Research (Part A) 100:797–800, 2014. © 2014 Wiley Periodicals, Inc.
CRISPR/Cas9‐mediated genome engineering: An adeno‐associated viral (AAV) vector toolbox
Authors: Senís Elena , Fatouros Chronis , Große Stefanie , Wiedtke Ellen , Niopek Dominik , Mueller Ann‐Kristin , Börner Kathleen , Grimm Dirk 
Published: September 2014

AbstractIts remarkable ease and efficiency make the CRISPR (clustered regularly interspaced short palindromic repeats) DNA editing machinery highly attractive as a new tool for experimental gene annotation and therapeutic genome engineering in eukaryotes. Here, we report a versatile set of plasmids and vectors derived from adeno‐associated virus (AAV) that allow robust and specific delivery of the two essential CRISPR components – Cas9 and chimeric g(uide)RNA – either alone or in combination. All our constructs share a modular design that enables simple and stringent guide RNA (gRNA) cloning as well as rapid exchange of promoters driving Cas9 or gRNA. Packaging into potent synthetic AAV capsids permits CRISPR delivery even into hard‐to‐transfect targets, as shown for human T‐cells. Moreover, we demonstrate the feasibility to direct Cas9 expression to or away from hepatocytes, using a liver‐specific promoter or a hepatic miRNA binding site, respectively. We also report a streamlined and economical protocol for detection of CRISPR‐induced mutations in less than 3 h. Finally, we provide original evidence that AAV/CRISPR vectors can be exploited for gene engineering in vivo, as exemplified in the liver of adult mice. Our new tools and protocols should foster the broad application of CRISPR technology in eukaryotic cells and organisms, and accelerate its clinical translation into humans.
Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry
Authors: Gu Dongyu , Yang Yi , Chen Qibin , Habasi Madina , Zhao Jiangyu , Aisa Haji Akber 
Published: September 2014

AbstractRupestonic acid, a potential anti‐influenza agent, is an important and characteristic compound in Artemisia rupestris L., a well‐known traditional Uighur medicine for the treatment of colds. In the present study, high‐performance liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry was used to detect and identify the metabolites in rat urine after oral administration of rupestonic acid. A total of 10 metabolites were identified or partially characterized. The structure elucidations of the metabolites were performed by comparing the changes in accurate molecular masses and fragment ions with those of the parent compound. The results showed that the main metabolites of rupestonic acid in rat urine were formed by oxidation, hydrogenation and glucuronidation. A metabolism pathway was proposed for the first time based on the characterized structures. This metabolism study can provide essential information for drug discovery, design and clinical application of rupestonic acid. Copyright © 2014 John Wiley & Sons, Ltd.
A realistic generator of power quality disturbances for practicing in courses of electrical engineering
Authors: Montenegro Davis , Hernandez Miguel E. , Ramos Gustavo A. 
Published: September 2014

AbstractThis paper presents a realistic generator of power quality (PQ) disturbances developed using real time—hardware in the loop (RT‐HIL) technologies; the aim is to reduce the gap between the PQ mathematical theory and its practical application by improving the technical skills of students through the use of instruments in a controlled and safe laboratory environment. The implementation of this interactive teaching tool in a graduate level course has significantly enhanced the communication process between the teacher and students and thus, resulted in a highly effective teaching methodology. © 2014 Wiley Periodicals, Inc. Comput Appl Eng Educ 23:391–402, 2015; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21609
Regulatory FeII/III Heme: The Reconstruction of a Molecule's Biography
Authors: Kühl Toni , Imhof Diana 
Published: September 2014

AbstractMore than 20 years of research on heme as a temporary effector molecule of proteins have revealed its widespread impact on virtually all primary functions in the human organism. As our understanding of this influence is still growing, a comprehensive overview of compiled data will give fresh impetus for creativity and developing new strategies in heme‐related research. From known data concerning heme‐regulated proteins and their involvement in the development of diseases, we provide concise information of FeII/III heme as a regulator and the availability of “regulatory heme”. The latter is dependent on the balance between free and bound FeII/III heme, here termed “hemeostasis”. Imbalance of this system can lead to the development of diseases that were not always attributed to this small molecule. Diseases such as cancer or Alzheimer's disease highlight the reawakened interest in heme, whose function was previously believed to be completely understood.
Prolonged survival in metastatic colorectal cancer following chemotherapy
Authors: Paul Doru , Gold Menachem , Nouraddin Nouraddin 
Published: September 2014

Key Clinical MessageThe cost of treating metastatic colorectal cancer has increased significantly after the introduction of targeted antivascular therapies. We report the unusual case of a patient with colorectal cancer with several large liver metastases at diagnosis, who was cured after removal of the primary tumor and treatment with 5‐FU/LV only.
Transcatheter CoreValve valve‐in‐valve implantation in a stentless porcine aortic valve for severe aortic regurgitation
Authors: Yong Celina M. , Buchbinder Maurice , Giacomini John C. 
Published: September 2014

Key Clinical MessageWe describe the first valve‐in‐valve Corevalve transcatheter aortic valve replacement in the St. Jude Toronto stentless porcine aortic valve in the United States, which enabled this 59‐year‐old patient with a history of bacterial endocarditis and aortic regurgitation to avoid heart transplant with complete resolution of his severe left ventricular dysfunction.
Snapshots in surgery: small bowel intussusception following ileojejunal bypass
Authors: Ward Joseph , Jaber Basel , Leaman Charlotte , Barry Jonathan , Khot Umesh 
Published: September 2014

Key Clinical MessageJejunal intussusception is a known complication of ileojejunal bypass surgery for obesity that may present as an acute abdomen. It can be avoided if the jejunum is anchored to the transverse mesocolon intra‐operatively.
CNN Pincer Ruthenium Catalysts for Hydrogenation and Transfer Hydrogenation of Ketones: Experimental and Computational Studies
Authors: Baratta Walter , Baldino Salvatore , Calhorda Maria José , Costa Paulo J. , Esposito Gennaro , Herdtweck Eberhardt , Magnolia Santo , Mealli Carlo , Messaoudi Abdelatif , Mason Sax A. , Veiros Luis F. 
Published: September 2014

AbstractReaction of [RuCl(CNN)(dppb)] (1‐Cl) (HCNN=2‐aminomethyl‐6‐(4‐methylphenyl)pyridine; dppb=Ph2P(CH2)4PPh2) with NaOCH2CF3 leads to the amine‐alkoxide [Ru(CNN)(OCH2CF3)(dppb)] (1‐OCH2CF3), whose neutron diffraction study reveals a short RuO⋅⋅⋅HN bond length. Treatment of 1‐Cl with NaOEt and EtOH affords the alkoxide [Ru(CNN)(OEt)(dppb)]⋅(EtOH)n (1‐OEt⋅n EtOH), which equilibrates with the hydride [RuH(CNN)(dppb)] (1‐H) and acetaldehyde. Compound 1‐OEt⋅n EtOH reacts reversibly with H2 leading to 1‐H and EtOH through dihydrogen splitting. NMR spectroscopic studies on 1‐OEt⋅n EtOH and 1‐H reveal hydrogen bond interactions and exchange processes. The chloride 1‐Cl catalyzes the hydrogenation (5 atm of H2) of ketones to alcohols (turnover frequency (TOF) up to 6.5×104 h−1, 40 °C). DFT calculations were performed on the reaction of [RuH(CNN′)(dmpb)] (2‐H) (HCNN′=2‐aminomethyl‐6‐(phenyl)pyridine; dmpb=Me2P(CH2)4PMe2) with acetone and with one molecule of 2‐propanol, in alcohol, with the alkoxide complex being the most stable species. In the first step, the Ru‐hydride transfers one hydrogen atom to the carbon of the ketone, whereas the second hydrogen transfer from NH2 is mediated by the alcohol and leads to the key “amide” intermediate. Regeneration of the hydride complex may occur by reaction with 2‐propanol or with H2; both pathways have low barriers and are alcohol assisted.
The π‐Back‐Bonding Modulation and Its Impact in the Electronic Properties of CuII Antineoplastic Compounds: An Experimental and Theoretical Study
Authors: García‐Ramos Juan Carlos , Galindo‐Murillo Rodrigo , Tovar‐Tovar Araceli , Alonso‐Saenz Ana Luisa , Gómez‐Vidales Virginia , Flores‐Álamo Marcos , Ortiz‐Frade Luis , Cortes‐Guzmán Fernando , Moreno‐Esparza Rafael , Campero Antonio , Ruiz‐Azuara Lena 
Published: September 2014

AbstractA complete study of the electronic density distribution in antineoplastic mixed chelate complexes of the type [Cu(NN)(glycinate)H2O]NO3 (NN=2,2′‐bipyridine (bpy) (1), 4,4′‐dimethyl‐bpy (2), 5,5′‐dimethyl‐2,2′‐bipyridine (3), 1,10‐phenanthroline (phen) (4), 4‐methyl‐phen (5); 5‐methyl‐phen (6); 4,7‐dimethyl‐phen (7), 5,6‐dimethyl‐phen (8), and 3,4,7,8‐tetramethyl‐phen (9)), a family known as Casiopeínas, was carried out with cyclic voltammetry, EPR, and computational methods. Crystal structures of 1⋅H2O, 2⋅H2O, 3⋅H2O, 6⋅H2O, and 8⋅H2O show the variability in the geometries adopted by the copper compounds in the solid state. Experimental properties are described employing electronic descriptors obtained from computational methods. The main descriptors found were: The total electronic population of the metal ion (N(Cu)), delocalization of the metal ion electrons over the donor atoms (Δ(Cu)), atomic dipolar moment (μ(Cu)), and the atomic quadrupole moment (Q(Cu)). It was found that π‐back‐bonding is the principal factor that modulates the distribution of the electron density around the metal ion. The electronic descriptors obtained from the computational approach can be used as electronic descriptors of inorganic compounds that have shown antiproliferative activities instead the experimental data, aiding the rational design of good candidates of metal‐based drugs.
Adding Remnant Magnetization and Anisotropic Exchange to Propeller‐like Single‐Molecule Magnets through Chemical Design
Authors: Westrup Kátia Cristina M. , Boulon Marie‐Emmanuelle , Totaro Pasquale , Nunes Giovana G. , Back Davi F. , Barison Andersson , Jackson Martin , Paulsen Carley , Gatteschi Dante , Sorace Lorenzo , Cornia Andrea , Soares Jaísa F. , Sessoli Roberta 
Published: September 2014

AbstractThe selective replacement of the central iron(III) ion with vanadium(III) in a tetrairon(III) propeller‐shaped single‐molecule magnet has allowed us to increase the ground spin state from S=5 to S=13/2. As a consequence of the pronounced anisotropy of vanadium(III), the blocking temperature for the magnetization has doubled. Moreover, a significant remnant magnetization, practically absent in the parent homometallic molecule, has been achieved owing to the suppression of zero‐field tunneling of the magnetization for the half‐integer molecular spin. Interestingly, the contribution of vanadium(III) to the magnetic anisotropy barrier occurs through the anisotropic exchange interaction with iron(III) spins and not through single ion anisotropy as in most single‐molecule magnets.
Enantioselective Construction of 2,3‐Dihydrofuro[2,3‐b]quinolines through Supramolecular Hydrogen Bonding Interactions
Authors: Zhong Fangrui , Bach Thorsten 
Published: September 2014

AbstractThe first asymmetric synthesis of 2,3‐dihydrofuro[2,3‐b]quinolines has been achieved by a cascade asymmetric aziridination/intramolecular ring‐opening process of differently substituted 3‐alkenylquinolones. Good yields and high enantioselectivities (up to 78 % yield and 95 % ee) were recorded when employing 2,2,2‐trichloroethoxysulfonamide as the nitrene source, PhI(OCOtBu)2 as the oxidant, and a chiral C2‐symmetric RhII complex as the catalyst (1 mol %). The catalyst bears two lactam motifs, which serve as binding sites for substrate coordination through supramolecular hydrogen‐bonding interactions.
ChemInform Abstract: La3Si6N11.
Authors: Yamane Hisanori , Nagura Toshiki , Miyazaki Tomohiro 
Published: September 2014

AbstractColorless transparent single crystals of the title compound are prepared by high‐pressure high‐temperature reaction of LaN and Si3N4 (BN crucible, 2273 K, 0.85 MPa N2, 2 h).
ChemInform Abstract: Nickel Hexayttrium Decaiodide, [NiY6]I10.
Authors: Steinberg Simon , Meyer Gerd 
Published: September 2014

AbstractComproportionation reactions of YI3, Y, and Ni leads to the formation of the title compound (sealed Ta tube in an evacuated silica tube, 1050 °C, 1 week) which is isostructural with the prototypical [RuY6]I10.
ChemInform Abstract: Ba4GaN3O.
Authors: Hashimoto Takayuki , Yamane Hisanori 
Published: September 2014

AbstractRed transparant platelet‐shaped single crystals of the title compound are grown by the Na flux method from a mixture of Ba, Ga, Na, Si, and NaN3 (BN crucible in stainless steel tube, 750 °C, 2 h).
ChemInform Abstract: Na4.25Mo15S19: A Novel Ternary Reduced Molybdenum Sulfide Containing Mo6 and Mo9 Clusters.
Authors: Salloum D. , Gougeon P. , Gall P. 
Published: September 2014

AbstractSingle crystals of the title compound are prepared by ion exchange of In3+xMo15S19 with an excess of NaI (evacuated silica tube, 1073 K, 2 d).
ChemInform Abstract: Intercalation‐Driven Reversible Control of Magnetism in Bulk Ferromagnets.
Authors: Dasgupta Subho , Das Bijoy , Knapp Michael , Brand Richard. A. , Ehrenberg Helmut , Kruk Robert , Hahn Horst 
Published: September 2014

AbstractNondestructive intercalation and de‐intercalation of mobile Li ions in γ‐Fe2O3 results in a significant reversible change of the magnetic state of the material.