bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flow Dimensions on Daily Activities with the Spanish Version of the Flow Scale (DFS)
Authors: Rufi Sergi , Javaloy Federico , Batista-Foguet Joan M. , Solanas Antonio , Páez Darío 
Published: May 2014

AbstractA sample of 250 students of psychology with an average age of 20.37 years, answered the Flow Q questionnaire indicating their favorite flow activity, and the Spanish version of the Dispositional Flow Scale (DFS). A confirmatory factor analysis assessed the DFS construct validity of the flow model on daily activities. Both a hierarchical model of eight first order factors reflecting a second order global flow factor, and a model with eight formative first order flow dimensions, showed good fit and discriminant power. Most optimal activities were found to be individual and structured, such as studying, reading and certain forms of individual sports. Leisure activities turned out to be more rewarding than studying. Sports displayed more flow, clear goals, merging of action and awareness, and autotelic experience. Reading also showed more flow, balance of challenge and skills, feedback, merging of action and awareness, and loss of self-consciousness. On the other hand, studying displayed less flow, merging of action and awareness, and autotelic experience.
Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy
Authors: Nakamura Y , Kanemaru K , Kojima R , Hashimoto Y , Marunouchi T , Oka N , Ogura T , Tanonaka K , Fukami K 
Published: May 2014

AbstractPhospholipase C (PLC) is a key enzyme in phosphoinositide turnover. Among 13 PLC isozymes, PLCδ1 and PLCδ3 share high sequence homology and similar tissue distribution, and are expected to have functional redundancy in many tissues. We previously reported that the simultaneous loss of PLCδ1 and PLCδ3 caused embryonic lethality because of excessive apoptosis and impaired vascularization of the placenta. Prenatal death of PLCδ1/PLCδ3 double-knockout mice hampered our investigation of the roles of these genes in adult animals. Here, we generated PLCδ1/PLCδ3 double-knockout mice that expressed PLCδ1 in extra-embryonic tissues (cDKO mice) to escape embryonic lethality. The cDKO mice were born at the expected Mendelian ratio, which indicated that the simultaneous loss of PLCδ1 and PLCδ3 in the embryo proper did not impair embryonic development. However, half of the cDKO mice died prematurely. In addition, the surviving cDKO mice spontaneously showed cardiac abnormalities, such as increased heart weight/tibial length ratios, impaired cardiac function, cardiac fibrosis, dilation, and hypertrophy. Predating these abnormalities, excessive apoptosis of their cardiomyocytes was observed. In addition, siRNA-mediated simultaneous silencing of PLCδ1 and PLCδ3 increased apoptosis in differentiated-H9c2 cardiomyoblasts. Activation of Akt and protein kinase C (PKC) θ was impaired in the hearts of the cDKO mice. siRNA-mediated simultaneous silencing of PLCδ1 and PLCδ3 also decreased activated Akt and PKCθ in differentiated-H9c2 cardiomyoblasts. These results indicate that PLCδ1 and PLCδ3 are required for cardiomyocyte survival and normal cardiac function.
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
Authors: van de Weijer Michael L. , Bassik Michael C. , Luteijn Rutger D. , Voorburg Cornelia M. , Lohuis Mirjam A.M. , Kremmer Elisabeth , Hoeben Rob C. , LeProust Emily M. , Chen Siyuan , Hoelen Hanneke , Ressing Maaike E. , Patena Weronika , Weissman Jonathan S. , McManus Michael T. , Wiertz Emmanuel J.H.J. , Lebbink Robert Jan 
Published: May 2014

AbstractMisfolded ER proteins are retrotranslocated into the cytosol for degradation via the ubiquitin–proteasome system. The human cytomegalovirus protein US11 exploits this ER-associated protein degradation (ERAD) pathway to downregulate HLA class I molecules in virus-infected cells, thereby evading elimination by cytotoxic T-lymphocytes. US11-mediated degradation of HLA class I has been instrumental in the identification of key components of mammalian ERAD, including Derlin-1, p97, VIMP and SEL1L. Despite this, the process governing retrotranslocation of the substrate is still poorly understood. Here using a high-coverage genome-wide shRNA library, we identify the uncharacterized protein TMEM129 and the ubiquitin-conjugating E2 enzyme UBE2J2 to be essential for US11-mediated HLA class I downregulation. TMEM129 is an unconventional C4C4-type RING finger E3 ubiquitin ligase that resides within a complex containing various other ERAD components, including Derlin-1, Derlin-2, VIMP and p97, indicating that TMEM129 is an integral part of the ER-resident dislocation complex mediating US11-induced HLA class I degradation.
The tobacco genome sequence and its comparison with those of tomato and potato
Authors: Sierro Nicolas , Battey James N.D. , Ouadi Sonia , Bakaher Nicolas , Bovet Lucien , Willig Adrian , Goepfert Simon , Peitsch Manuel C. , Ivanov Nikolai V. 
Published: May 2014

AbstractThe allotetraploid plant Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences are currently available. Here we report high-quality draft genomes for three main tobacco varieties. These genomes show both the low divergence of tobacco from its ancestors and microsynteny with other Solanaceae species. We identify over 90,000 gene models and determine the ancestral origin of tobacco mosaic virus and potyvirus disease resistance in tobacco. We anticipate that the draft genomes will strengthen the use of N. tabacum as a versatile model organism for functional genomics and biotechnology applications.
Rock-salt-type lithium metal sulphides as novel positive-electrode materials
Authors: Sakuda Atsushi , Takeuchi Tomonari , Okamura Kazuhiro , Kobayashi Hironori , Sakaebe Hikari , Tatsumi Kuniaki , Ogumi Zempachi 
Published: May 2014

AbstractOne way of increasing the energy density of lithium-ion batteries is to use electrode materials that exhibit high capacities owing to multielectron processes. Here, we report two novel materials, Li2TiS3 and Li3NbS4, which were mechanochemically synthesised at room temperature. When used as positive-electrode materials, Li2TiS3 and Li3NbS4 charged and discharged with high capacities of 425 mA h g−1 and 386 mA h g−1, respectively. These capacities correspond to those resulting from 2.5- and 3.5-electron processes. The average discharge voltage was approximately 2.2 V. It should be possible to prepare a number of high-capacity materials on the basis of the concept used to prepare Li2TiS3 and Li3NbS4.
Quantification of Experienced Hearing Problems With Item Response Theory
Authors: Chenault Michelene , Berger Martijn , Kremer Bernd , Anteunis Lucien 
Published: May 2014

Purpose
The purpose of this study was to improve the effectiveness of adult hearing screens and demonstrate that interventions assessment methods are needed that address the individual's experienced hearing. Item response theory, which provides a methodology for assessing patient-reported outcomes, is examined here to demonstrate its usefulness in hearing screens and interventions.

Method
The graded response model is applied to a scale of 11 items assessing perceived hearing functioning and 10 items assessing experienced social limitations completed by a sample of 212 persons age 55+ years. Fixed and variable slope models are compared. Discrimination and threshold parameters are estimated and information functions evaluated.

Results
Variable slope models for both scales provided the best fit. The estimated discrimination parameters for all items except for one in each scale were good if not excellent (1.5–3.4). Threshold values varied, demonstrating the complementary and supplementary value of items within a scale. The information provided by each item varies relative to trait values so that each scale of items provides information over a wider range of trait values.

Conclusion
Item response theory methodology facilitates the comparison of items relative to their discriminative ability and information provided and thus provides a basis for the selection of items for application in a screening setting.
Age-Dependent Changes in Temporal-Fine-Structure Processing in the Absence of Peripheral Hearing Loss
Authors: Füllgrabe Christian 
Published: May 2014

Purpose
In this study, the author sought to investigate if and when the ability to process temporal-fine-structure (TFS) cues deteriorates with age in adults with audiometrically normal hearing sensitivity.

Method
Using a cross-sectional design, the author assessed TFS sensitivity in 102 normal-hearing adults sampled from across the entire range of adulthood (ages 18–90 years), using 2 psychophysical tests for the assessment of within- and across-ear TFS processing.

Results
Both types of TFS sensitivity (monaural and binaural) declined gradually starting in young adulthood, with the earliest significant deficit already apparent in early midlife (i.e., between ages 40 and 49 years). TFS sensitivity was not correlated with absolute sensitivity at the test frequency.

Conclusions
Some suprathreshold auditory processing abilities decline throughout adulthood, even when an individual's peripheral hearing is clinically normal. These deficits are not captured by a conventional, audiometric hearing assessment but may contribute to the increasing difficulties with age to identify speech in noisy environments. From a methodological point of view, the existence of such age effects warrants the use of age-matched participant groups when comparing normal and impaired peripheral hearing.
A Brief Overview of Factors Affecting Speech Intelligibility of People With Hearing Loss: Implications for Amplification
Authors: Ching Teresa Y. C. , Dillon Harvey 
Published: May 2014

Purpose
The authors aimed to determine the predictability of speech intelligibility of people with different degrees of hearing loss from audibility and other factors.

Method
After a brief overview of why people with hearing loss have greater difficulty in understanding speech than people with normal hearing, the authors describe a study that was aimed to predict speech intelligibility from audibility, psychoacoustic abilities, cognitive ability, and age.

Results
The study showed that the ability of people with hearing loss to extract speech information from an audible signal decreased with increase in hearing loss. This hearing loss desensitization was significantly related to hearing thresholds, sharpness of psychophysical tuning curves, presence of dead regions, age, and cognitive ability. After allowing for the effects of hearing loss, the authors found that speech intelligibility was significantly related to age and cognitive ability. The effects did not vary with frequency.

Conclusions
The current evidence supports the allowance of hearing loss desensitization in prescribing amplification that is aimed to maximize speech intelligibility. There is insufficient evidence to recommend the inclusion of estimates of frequency resolution or dead regions in prescribing amplification.
The Awareness of Doctoral-Level Professions Among Entering College Students
Authors: Donai Jeremy J. , Hicks Candace B. , McCart Mallory 
Published: May 2014

PurposeThe purpose of this study was to survey entering college students' awareness of the profession of audiology, as well as to compare the students' awareness of audiology to their awareness of roles in 2 other doctoral-level professions.MethodA survey examining students' awareness and perception of the profession of audiology was administered in 2009 at the California University of Pennsylvania (Emanuel, Donai, & Araj, 2012). A modified survey, which included questions about awareness of the profession of audiology as well as podiatry and optometry, was distributed in 2012.ResultsSurvey data suggest that, overall, students were more accurate in describing the profession of optometry compared to audiology, but no difference existed between their awareness of podiatry and audiology. However, students with self-reported awareness of the three professions were more accurate in describing the professions of podiatry and optometry as compared to audiology.ConclusionsResults of this distribution suggest an upward trend in audiology awareness among students. However, the awareness of audiology as a potential career path is low relative to that of the professions of optometry and podiatry for those with self-reported knowledge. Future surveys should be distributed to entering college students at other universities, varying in size, location, and demographics.
Use of the Implicit Association Test for the Measurement of Tinnitus-Related Distress
Authors: Moring John , Bowen Anne , Thomas Jenifer 
Published: May 2014

Purpose
A priming stimulus activates and increases an association with the target stimulus. The goal of this research was to investigate whether current tinnitus measures are susceptible to increased error due to priming and, if so, to examine the feasibility of using the Implicit Association Test (IAT; Greenwald, McGhee, & Schwartz, 1998) for an alternative measurement of tinnitus-related distress.

Method
Participants completed 2 tinnitus-related questionnaires and the IAT online.

Results
Although participants with tinnitus did not view sound-related words as significantly more negative and IAT scores did not predict scores on the Tinnitus Handicap Inventory (Newman, Jacobson, & Spitzer, 1996), priming did affect negative implicit attitudes toward sound-related words.

Conclusions
On the basis of these results, it is suggested that current tinnitus measures may be susceptible to priming error and that future studies should continue to pursue how the IAT can be utilized in the measure of tinnitus-related distress. Moreover, researchers should develop overt-behavioral measurements that can assess the validity of a tinnitus IAT.
Trudinger-Moser type inequalities for weighted Sobolev spaces involving fractional dimensions
Authors: de Oliveira José , do Ó João 
Published: May 2014

We derive sharp Trudinger-Moser inequalities for weighted Sobolev spaces and prove the existence of extremal functions. The inequalities we obtain here extend for fractional dimensions the classical results in the radial case. The main ingredient used in our arguments reveals a new proof of a result due to J. Moser for which we give an improved version.
Early Effect of Tidal Volume on Lung Injury Biomarkers in Surgical Patients with Healthy Lungs
Authors: Fernandez-Bustamante Ana , Klawitter Jelena , Repine John E. , Agazio Amanda , Janocha Allison J. , Shah Chirag , Moss Marc , Douglas Ivor S. , Tran Zung Vu , Erzurum Serpil C. , Christians Uwe , Seres Tamas 
Published: May 2014

Abstract

Background:
The early biological impact of short-term mechanical ventilation on healthy lungs is unknown. The authors aimed to characterize the immediate tidal volume (VT)-related changes on lung injury biomarkers in patients with healthy lungs and low risk of pulmonary complications.

Methods:
Twenty-eight healthy patients for knee replacement surgery were prospectively randomized to volume-controlled ventilation with VT 6 (VT6) or 10 (VT10) ml/kg predicted body weight. General anesthesia and other ventilatory parameters (positive end-expiratory pressure, 5 cm H2O, Fio
2, 0.5, respiratory rate titrated for normocapnia) were managed similarly in the two groups. Exhaled breath condensate and blood samples were collected for nitrite, nitrate, tumor necrosis factor-α, interleukins-1β, -6, -8, -10, -11, neutrophil elastase, and Clara Cell protein 16 measurements, at the onset of ventilation and 60 min later.

Results:
No significant differences in biomarkers were detected between the VT groups at any time. The coefficient of variation of exhaled breath condensate nitrite and nitrate decreased in the VT6 but increased in the VT10 group after 60-min ventilation. Sixty-minute ventilation significantly increased plasma neutrophil elastase levels in the VT6 (35.2 ± 30.4 vs. 56.4 ± 51.7 ng/ml, P = 0.008) and Clara Cell protein 16 levels in the VT10 group (16.4 ± 8.8 vs. 18.7 ± 9.5 ng/ml, P = 0.015). Exhaled breath condensate nitrite correlated with plateau pressure (r = 0.27, P = 0.042) and plasma neutrophil elastase (r = 0.44, P = 0.001). Plasma Clara Cell protein 16 correlated with compliance (r = 0.34, P = 0.014).

Conclusions:
No tidal volume-related changes were observed in the selected lung injury biomarkers of patients with healthy lungs after 60-min ventilation. Plasma neutrophil elastase and plasma Clara Cell protein 16 might indicate atelectrauma and lung distention, respectively.
Prelacteal Feeding of Newborns in Postconflict Timor‐Leste
Authors: Khanal Vishnu , Lee Andy H. , Nunes Brites da Cruz Jonia Lourenca , Karkee Rajendra 
Published: May 2014

ABSTRACTObjectives:The aim of the present study was to investigate the prevalence of prelacteal feeding and its associated factors in Timor‐Leste using updated data from the national survey.Methods:Complex sample analysis was undertaken to account for the 2‐stage cluster design of the Demographic and Health Survey 2009–2010. Backward stepwise logistic regression was conducted to ascertain factors associated with the prevalence of prelacteal feeding.Results:A total of 4821 mother–infant pairs were included in the analysis. The prevalence of prelacteal feeding was 12.3% (95% confidence interval [CI] 11.1–13.5). The most popular prelacteal food was plain water (50.7%), followed by glucose/sugar water (32.5%) and milk other than breast milk (22.7%). Older mothers (35–49 years), mothers with upper socioeconomic status, those who perceived their newborns as small size, and those residing in urban areas were approximately 1.5 times more likely to give prelacteal feeds, whereas women who followed religions other than Roman Catholic had twice the risk (adjusted odds ratio 1.98; 95% CI 1.16–3.41).Conclusions:Antenatal and postnatal counselling sessions that promote exclusive breast‐feeding and discourage prelacteal feeding are needed that specifically target these vulnerable subgroups of Timorese mothers.
The Arabidopsis ZINC FINGER PROTEIN3 Interferes with Abscisic Acid and Light Signaling in Seed Germination and Plant Development
Authors: Joseph Mary Prathiba , Papdi Csaba , Kozma-Bognár László , Nagy István , López-Carbonell Marta , Rigó Gábor , Koncz Csaba , Szabados László 
Published: May 2014

AbstractSeed germination is controlled by environmental signals, including light and endogenous phytohormones. Abscisic acid (ABA) inhibits, whereas gibberellin promotes, germination and early seedling development, respectively. Here, we report that ZFP3, a nuclear C2H2 zinc finger protein, acts as a negative regulator of ABA suppression of seed germination in Arabidopsis (Arabidopsis thaliana). Accordingly, regulated overexpression of ZFP3 and the closely related ZFP1, ZFP4, ZFP6, and ZFP7 zinc finger factors confers ABA insensitivity to seed germination, while the zfp3 zfp4 double mutant displays enhanced ABA susceptibility. Reduced expression of several ABA-induced genes, such as RESPONSIVE TO ABSCISIC ACID18 and transcription factor ABSCISIC ACID-INSENSITIVE4 (ABI4), in ZFP3 overexpression seedlings suggests that ZFP3 negatively regulates ABA signaling. Analysis of ZFP3 overexpression plants revealed multiple phenotypic alterations, such as semidwarf growth habit, defects in fertility, and enhanced sensitivity of hypocotyl elongation to red but not to far-red or blue light. Analysis of genetic interactions with phytochrome and abi mutants indicates that ZFP3 enhances red light signaling by photoreceptors other than phytochrome A and additively increases ABA insensitivity conferred by the abi2, abi4, and abi5 mutations. These data support the conclusion that ZFP3 and the related ZFP subfamily of zinc finger factors regulate light and ABA responses during germination and early seedling development.
Folded conformations due to arene interactions in dissymmetric and symmetric butylidene-linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine
Authors: Avasthi Kamlakar , Shukla Lakshmi , Kant Ruchir , Ravikumar Krishnan 
Published: May 2014

The butylidene-linker models 1-[2-(2,6-dimethylsulfanyl-9H-purin-9-yl)-2-methylidenepropyl]-4,6-bis(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine, C18H20N8S4, (XI), 7,7′-(2-methylidenepropane-1,3-diyl)bis[3-methyl-2-methylsulfanyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one], C20H22N6O2S2, (XIV), and 7-[2-(4,6-dimethylsulfanyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylidenepropyl]-3-methyl-2-methylsulfanyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one, C19H21N7OS3, (XV), show folded conformations in solution, as shown by1H NMR analysis. This folding carries over to the crystalline state. Intramolecular π–π interactions are observed in all three compounds, but only (XIV) shows additional intramolecular C—H...π interactions in the solid state. As far as can be established, this is the first report incorporating the pyrrolo[2,3-d]pyrimidine nucleus for such a study. In addition to the π–π interactions, the crystal structures are also stabilized by other weak intermolecular C—H...S/N/O and/or S...N/S interactions.
The elements of parametrical regulation theory for computable general equilibrium models
Authors: Ashimov Abdykappar , Sultanov Bahyt , Adilov Zheksenbek , Borovskiy Yuriy , Borovskiy Nikolay , Ashimov Askar 
Published: May 2014

PurposeThe purpose of this paper is to present some results of the development of parametrical regulation theory elements for computable general equilibrium models (CGE models), taking into consideration their peculiarities.Design/methodology/approachTheoretical results have been obtained by means of applying geometrical methods for variational problems and methods of the theory of discrete dynamic systems. These results have been used for solving concrete practical problems.FindingsThe authors proved a statement on the existence of solution for variational calculus problem on the choice of the optimal laws of parametrical regulation within the given finite set of algorithms for discrete dynamic systems. A statement has been proved on sufficient conditions for the existence of an extremal's bifurcation point of variational calculus problem on the choice of the optimum laws of parametrical regulation within the given finite set of algorithms for discrete dynamic systems. Optimal laws of parametrical regulation (on the level of one and two parameters) of economic system evolution on the basis of the examined mathematical model have been defined. The bifurcation line was constructed for the given area of uncontrolled parameter values.Practical implicationsThe research results can be applied for the choice and realization of an effective state budget and tax policy.Originality/valueThe paper elaborates the elements of parametrical regulation theory of economic system development on the basis of CGE models and shows the effectiveness of parametrical regulation theory application on the example of one CGE model.