bluuebunny/crossref_metadata_2025_split huggingface dataset:
518 – Intermittent Theta Burst Stimulation (ITBS) for the Treatment of Negative Symptoms in Schizophrenia
Authors: Bation R. , Brunelin J. , Damasceno C. , D’Amato T. , Poulet E. 
Published: July 2013

Introduction:High frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) has been shown effective for reducing persistant negative symptoms of schizophrenia. Intermittent theta burst stimulation (iTBS) is a new paradigm of rTMS that allowed more sustained facilitation effect.Aims:The aim of this study is to investigate the effect of theta burst in reduction of persistant negative symptoms in schizophrenia.Methods:24 adult schizophrenia outpatients were assigned to receive iTBSat 80% motor threshold, or sham TMS over the left DLPFC, daily; for 20 sessions. The primary outcome measure was the Scale for the Assessment of Negative Symptoms (SANS).score. Secondary outcomes included depression as measured with the Calgary Depression Scale (CDS), and cogntion as assessed with digit span and trail making test. Patients were followed-up 6 months afterwards.Results:The primary outcome measure (change in Scale for Assessment of Negative Symptoms score) showed a statistically significant drop at month 1, 3 and 6 for the iTBS group, but not ther placebo groups. Digit span and trail making test score were also significally improved after treatment in iTBS group. Calgary depression scale score did not demontrate any significant change.Conclusions:iTBS may serve as a relatively noninvasive treatment of the negative and neurocognitive deficits associated with schizophrenia.ClinicalTrials.gov Identifier: NCT00875498
521 – Serotoninergic Antidepressants and Anticoagulants in Psychogeriatric Wards, Mental Hospital Kromeriz, Czech Republic - What shall we do to Prevent from Serious Drug Interactions?
Authors: Luzny J. , Blazkova M. , Honzak F. , Bican V. , Vyrostkova O. , Indrakova A. , Pospisilova I. 
Published: July 2013

Introduction:Both serotoninergic antidepressants and anticoagulants are widely udes in psychogeriatry. These drugs can develop drug interactions with subsequent risk of bleeding.Objectives, aims:To determine risk of potential drug interactions between serotoninergic antidepressants and anticoagulants serotoninergic antidepressants and anticoagulants with subsequent risk of bleeding.Methods:Retrospective analysis of medical records and laboratory checks (INR values) in senior patients treated with serotoninergic antidepressants and anticoagulants (Mental hospital Kromeriz, Czech republic, year 2011).Results:In 15.5% of patients treated with combination serotoninergic antidepressant / anticoagulant the dosage of anticoagulant had to be decreased due to unwanted elevation of INR value. In 0.6% of patients the risk of bleeding was clinically evident.Conclusion:Serotoninergic antidepressants and anticoagulants are common drugs used in treating seniors with mental disorder and potential drug interactions between them should be taken into account.
523 – Datscan in Differential Diagnosis of Lewy Body Disease - Case Report
Authors: Luzny J. , Blazkova M. , Indrakova A. , Vyrostkova O. , Pospisilova I. 
Published: July 2013

Introduction:Differentiating Lewy Body Disease from dementia of Alzheimer's type might be difficult in clinical practice. Althought the clinical signs in both cathegories are well known, difficulties may occur in patients with incomplete clinical picture.Objectives and aims:Description of the case with incomplete clinical picture (women with unspecified dementia) and benefit of the DatCAN in differential diagnosis of clinically unclear dementia.Methods:Case report.Results:DatCAN helped in differential diagnosis of unspecified dementia. As the clinical picture of the case was incomplete and clinical diagnosis could not been done according diagnostic criteria, DatSCAN proved benefit in diagnostics of Lewy Body Disease.
536 – Acute Intermittent Porphyria and Cycloid Psychosis
Authors: Boersema C. , Daey Ouwens I.M. , Ruys T.A. , Gerrits M.C.F. , Vlasveld L.T. , Verhoeven W.M.A. 
Published: July 2013

Introduction:Acute intermittent porphyria (AIP) is a rare autosomal dominant inherited metabolic disease characterized by mutations in the porphobilinogen deaminase gene. This mutation may provoke neurotoxic levels of delta-aminolevulinic-acid and porphobilinogen, potentially resulting in an acute life-threatening clinical syndrome, characterized by psychiatric, in particular atypical psychotic, symptoms as well as severe neurological and gastrointestinal symptoms. Since the clinical presentation varies and symptoms are nonspecific, diagnosis is often made late.Objectives:Naming of alarm symptoms based on a recent case study.Methods:Description of a recent case supplemented with data from the literature.Results:The patient is a 46 year old woman who was admitted in 2007 with abdominal pain, an epileptic seizure and weakness, interpreted as a Guillain-Barre syndrome. In 2011 she was readmitted with severe abdominal pain, diarrhea, volatile psychotic symptoms and seizures, following a short period of excessive alcohol consumption. During admission she developed progressive weakness in the upper arms, shooting pains in the limbs and a feeling of tightness. Impaired abdominal breathing was suspected. Again, Guillain-Barré syndrome was considered, but additional studies did not support this diagnosis. Because of the recurrent character of symptomatology following alcohol abuse, acute (intermittent) porphyria was considered diagnostically. The dark-colored urine indeed contained significantly increased delta-aminolevulinic-acid and porphobilinogen concentrations. Additional (genetic) diagnosis follows.Conclusion:A recurrent disease course with severe gastrointestinal, neurological and psychiatric symptoms, following alcoholabuse, is suspect for AIP.
545 – Paranoid Schizophrenia in Kallmann Syndrome: Genetics and Psychopathology
Authors: Verhoeven W. , Egger J. , Onderwater T. , Hovens J. , De Leeuw N. , Hoefsloot L. 
Published: July 2013

Introduction:Kallmann syndrome (KS) is a genetically heterogenous and rare disorder characterized by the combination of hypothalamic hypogonadism and anosmia/hyposmia. In about one third of the patients, mutations have been identified in at least seven different genes. Apart from one published case report, virtually no data are available about possible neuropsychiatric symptoms in KS.Objectives:Studying the putative relationship between KS and schizophrenia.Aims:Investigating the genetic etiology in a patient with a clinical diagnosis of KS and paranoid schizophrenia.Methods:Detailed diagnostic evaluation including genetic analysis of an adult male patient with paranoid schizophrenia, hypogonadism and anosmia.Results:Psychiatric examination of the 28-years-old male patient disclosed negative psychotic symptoms only, following an acute paranoid schizophrenic episode one year before. He used 15mg aripiprazole daily and testosterone gel 20mg/gr. Hormonal panel showed extremely low levels of LH and FSH. MRI scanning of the brain demonstrated complete absence of the olfactory bulbs. Otolaryngeal examination disclosed complete anosmia. Neuropsychological assessment revealed subaverage intelligence distinctly disconcordant with premorbid functioning, markedly lowered speed of information processing, and impaired executive and social cognitive functions. Genome wide SNP array analysis and mutation analyses for the KAL1, FGFR1, PROK2, PROKR2, FGF8 and CHD7 genes, disclosed no genetic imbalance or any pathogenic mutation.Conclusions:This first report on a patient with KS and paranoid schizophrenia in whom extensive genetic analyses were performed, stipulates the need for studying a possible increased risk for psychiatric symptoms in patients with KS.
546 – Phelan-McDermid Syndrome and Atypical Bipolar Disorder
Authors: Verhoeven W. , Egger J. , De Leeuw N. 
Published: July 2013

Introduction:The Phelan-McDermid syndrome (PMD) is characterized by intellectual disability (ID), childhood hypotonia, severely delayed or absent speech, and autistic features without major dysmorphisms and somatic anomalies. Haploinsufficiency of the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene in 22q13.3 is thought to be causative for the PMD-phenotype comprising, in addition to sleep disturbances and deficits in language and communication, several behavioural abnormalities and increased reactivity to sensory stimuli. Data about neuropsychological dysfunctions or psychiatric symptoms are not available as yet.Objectives:Investigating the possible psychopathological phenotype of PMD.Aims:Diagnostic evaluation of one geriatric female and two male adult patients.Methods:Detailed neuropsychiatric and neuropsychological examination of 3 patients with genetically proven PMD.Results:In an adult male with a history of mood and behaviour fluctuations, psychiatric examination at the age of 24 disclosed symptoms of a severe major depression with irritability, loss of initiative, and marked sleep disturbances. Severe ID and marked deficits in expressive and receptive language were established. After addition of nortriptyline to valproic acid, depressive symptoms gradually remitted. His older brother has a similar history but with less severe symptomatology. The 70- years-old institutionalized female patient, had a history of affective and behavioural imbalance over many decades. Monotherapy with carbamazepine led to acceptable stabilization. Genetic evaluation in the two brothers and the female patient demonstated an identical loss of 2.15Mb and a 610kb deletion in 22q13.3, respectively, all including SHANK3 gene.Conclusions:Provisonal diagnosis of atypical bipolar disorder could be made in all three patients.
553 – Pseudo-In Patient Smoking Cessation Treatment for Three Mentally Retarded COPD Patients
Authors: Vitzthum K. , Mache S. , Salamero y Mur M. , Marly N. , Foehse S. , Pankow W. 
Published: July 2013

Nicotine addiction is still classified as a lifestyle instead of a disease in Germany, although recently established non smoking policies have shown remarkable effects on population's health and economic profits for health insurances. Scientific community is requesting more intensive cessation programs especially for certain patient groups such as lung cancer or copd affected persons. Mentally retarded have rarely been examined in terms of health risks or been in the focus of health promotion programs.In January 2012 we conducetd a pilotproject with three mentally retarded COPD patients (2 male, 1 female). A flat next to the hospital grounds was rented for one week and patients were enrolled in daily cognitive behavioural, medical and sports programs. Meals were consumed at the hospital cafeteria and leisure time acitivities were planned by regular counsellors and mobile nursing services. Booster sessions were held twice monthly at their assisted living homes. One male patient was successful all at once; while other two accomplished smokefree day time periods supported by NRT. During first six months of aftercare several attempts were taken leading to a three week lasting smoke free period for the second male patient. Female patient did not have any further motivation to quit. However improvements in medical condition and quality of life were observed.Intensified therapy might be a reasonable option for “complicated” patients.
555 – Sexual Function in Women with and without Children and Relationship with Marital Satisfaction
Authors: Pourakbaran E. 
Published: July 2013

Introduction:Sex, family environment, which is a natural extension of acceptance and satisfaction in preserving the familial system is effective for delivery due to circumstances during sexual behavior changes. But it changes because of special conditions of women daring pregnancy and after child birth.Materials and methods:120 cases of married women (60 women and 60 children with no children), age range 30-20 years, with a non-random sampling Vbgvnh available at the health centers were selected Vmtb specialty Obstetrics & Gynecology.Results:Showed that women who have not yet lived through the experience of pregnancy and improve sexual function (p =) 0/017) and the nature of marital satisfaction than And the mean score for each group, the average sexual women without children 6/3 and for women with children 3/3 is.Conclusion:The results suggest that married women without children also benefit satisfaction marital sexual satisfaction scores than women who have experienced childbirth have gained.And this is indicative of the important role satisfaction marital sex is important to mention that other factors are likely to determine the cause of marital sexual satisfaction, age, marital duration, economic factor have an important role in this field.
560 – Study and Comparison of Social Adjustment and Self Esteem in Blind & Normal Students of Torbat Heydarie
Authors: Pourakbaran E. 
Published: July 2013

Introduction:The present study investigates and compares in blind and normal students.social adjustment and self esteem.Methodology:To this end, a 120-subject sample, 60 blind students (30 male and 30 female), 60 normal students (30 male and 30 female), 12 to 18 years old, were selected. In data collection, we have used Coopersmith Self-Esteem Inventory and Gresham & Elliot social adjustment questionnaire; also Pearson Correlation Coefficient and T-Test were used to test the hypotheses.Result:Based on the Pearson Correlation results between social adjustment and self-esteem in blind students there is meaningful relationship. But this relationship is not meaningful for normal students.Conclusion:Comparing the average self-esteem in normal & blind students as well as social adjustment in blind & normal students, social adjustment in normal males and females, self esteem of blind males and females, shows no meaningful differences between both averages.Comparing self-esteem in normal male and female students shows meaningful difference.
575 – The Pattern of Drug Abuse based on Demographic Factors in Drug Users Represent their Addicts in Quchan, Iran
Authors: Hashemizadeh H. 
Published: July 2013

Background:Addiction is one of the major problems and concerns of the world today. The first step in combating a social phenomenon or disease, knowing it is correct. To determine the demographic characteristics and patterns of drug use has been done in this area.Methods:This is descriptive cross-sectional study. The analysis of data in prospective study examines the characteristics of addicts who voluntarily to one of the centers in the city Quchan withdrawal over a year for withdrawal referred deal.Results:Of the 753 cases studied 75% were male and others female. Education (3 / 51%) of them were illiterate and elementary level. Consumables highest among these people (65%), syrup, and then (4 / 24%), opium (7 / 7%) Crystal (7 / 2%) comprised of heroin. In (5 / 66%) cases the main method of extraction used, (8 / 32%) percent of eating, (26 / 0%) injection, (39 / 0%) and was snuff. Inhaler and drink any case was not reported. Majority People (9 / 58%), the first female consumption of opium, (4 / 39%), syrup and only (26 / 0%), injection materials were mentioned. (2 / 60%) have a history of drug addiction had already.Conclusion:Considering that the majority of cases of addiction in this city in men aged 30 to 39 years, Married, employed, with primary education and illiterate, and have a history of addiction relapse form provided in relation to knowledge Damage of addiction with this group seems to be necessary.
580 – Supportive Text Messages for Patients with Alcohol use Disorder and Comorbid Depression - How Useful are they for the Patients
Authors: Agyapong V.I.O. , Milnes J. , Farren C.K. 
Published: July 2013

Background:Despite the potential for using text message technology to manage patients with Alcohol Use Disorder (AUD) and comorbid depression, very little is known about the mechanism by which this improvement occurs.Aim:The aim of this study was to examine the perception of patients with AUD and comorbid depression about the usefulness of supportive text messages.Methods:Participants (n=26) with AUD and depression and completing an in-patient dual diagnosis treatment programme had twice daily supportive text messages delivered to their mobile phones for three months. Participants’ views were the sought on the usefulness of the supportive text messages using a self-designed semi-structured questionnaire.Results:Overall, 24 out of 26 patients were contactable for feedback giving a response rate of 92%. Of these 24 patients, 20(83%) reported that they always or often read the supportive text messages. 19(79%) patients expressed the view that they were either very satisfied or satisfied with the frequency with which the text messages were delivered with the same number reporting that the messages made them to feel supported by the team. 18(75%) patients reported that the text messages always or often reminded them to remain abstinent from alcohol. Finally, 20(83%) patients reported that the intervention had played a useful role in helping to improve their mental health.Conclusion:Text messages could help patients with AUD and depression remain abstinent and improve upon their mental wellbeing by providing increase support for patients.
581 – 6-Month Outcomes of a Single Blind Randomised Trial of Supportive Text Messaging for Depression and Comorbid Alcohol use Disorder
Authors: Agyapong V. , McLoughlin D.M. , Farren C.K. 
Published: July 2013

Background and objectives:Supportive text messages have the potential to provide personalised support for patients with depression and co-morbid Alcohol Use Disorder (AUD). The objectives of the study are to explore the six months follow-up effects of twice daily supportive text messages delivered over a three month period on mood and abstinence outcomes for patients with depression and co-morbid AUD.Methods:Participants (n=54) with a DSM IV diagnosis of unipolar depression and AUD who completed an in-patient dual diagnosis treatment programme were randomised to receive twice daily supportive text messages (n = 26) or a fortnightly thank you text message (n = 28) for three months. Primary outcome measures at six months were Beck's Depression Inventory (BDIII) scores and Cumulative Abstinence Duration (CAD). Trial registration: NCT0137868.Results:Unlike at three months, there was no statistically significant difference in six month BDI-II scores between the intervention (n=24) and control (n=24) groups; 13.28 (SD=8.7) vs. 15.08 (SD=11.37) respectively after adjusting for the baseline scores, F (1, 45) =0.192, p=0.66. There was also no significant difference in CAD between the text message group and the control group: 84.14 days (9.20) vs. 74.73 days (28.97), t= 1.422, df=41, p=0.16. However, patients in the intervention group had significantly higher days to first drink compared to those in the control group: 119.9 (47.7) vs. 62.4 (44.9), t=2.99, df=22, p=0.01.Conclusion:The effects of supportive text message intervention were not sustained beyond the period that the patients were receiving the intervention.
582 – Study of Correlation between Terrorisim and Mental Disorders at Ibin-alhaithim High Secure Unit
Authors: Humaidi N.S. 
Published: July 2013

Background:It is generally thought that schizophrenia does not predispose subjects to homicidal behavior However; many previous studies have suffered from notable methodological weaknesses. In particular, obtaining comprehensive study groups of violent offenders has been difficult. Iraqi police have been able to solve increasingly percentage of homicides during the last few years with gradual rebuilding of infrastructure of police and judicial system; these bodies are totally collapsed after fall down of previous regime.Objectives:To study the sociodemographic characteristics of schizophrenic charge patients with homicidal accusation, and to find out the characteristic of victims of patients admitted in the secure unit.Methods:file system In Ibin-AL-Hiatham Secure unit where examined for various socio demographic data, the 118homicidal admitted consequently in the secure unit were examined between July 2003, and July 2008.The files were systematically checked for DSM-IV schizophrenia criteria.Conclusion:The study revealed that the number of males dominant females, simply because males more liable to break the law than females, higher number of urban living offenders is over represented mainly because psychiatric services are more accessible to them than rural residents.Victims are mostly of first degree relatives of the offenders. In an Arab culture however as Iraq is one of them, issues related to honor killing and male jealousy which are assumed to be of delusional nature in this study, are relatively frequent.
622 – Suicidal Tendencies in a Community Sample of Adolescents in the Region of Prizren
Authors: Fanaj N. , Fanaj B. , Drevinja F. , Poniku I. 
Published: July 2013

Introduction:In many countries suicide is one of the leading causes of death among children and adolescents. Identifying young people at risk and offering effective treatment is a major concern of mental health policies.Objectives:To look for the presence of suicidal thinking, plans and attempts in adolescents.Aims:Measure the presence of suicidal tendencies having in mind possible correlation with psychological difficulties (measured by SDQ), level of depression, hopelessness and self-esteem of adolescents in one school sample.Methods:The sample of adolescents at school have been offered to fill out CESD, Hopelessness scale for children, Rosenberg self-esteem scale, SDQ questionnaire and four item adopted questions about suicidal tendencies. All data has been analyzed by SPSS 14.0.Results:In the sample of 768 adolescents (12-20yr, mean Age=17, 52) 22, 1% of them declared suicidal thinking, 3, 9% planed and 2, 2% attempted. About third of them didn’t find any reason for these tendencies. Females showed more suicidal tendencies but significantly only for thinking. Tobacco, alcohol and marihuana users have significantly more suicidality. Youths who declared more test anxiety have significantly more suicidal thinking. Significantly association is found between suicidal tendencies and psychological difficulties (emotional, conduct, hyperactivity and peers problems). Depression and high hopelessness also have significances. Suicidality is significantly higher in youths with normal self-esteem.Conclusions:Suicidality is much presented in our sample and showed significantly association with substance use, psychological difficulties, hopelessness, depression and normal self-esteem.
624 – Association of Apathy with Caregiver Burden in Amnestic Mild Cognitive Impairment
Authors: George M. , Whitfield T. , Walker Z. 
Published: July 2013

Objectives:The objective of this study is to examine an association between apathy and caregiver burden in amnestic mild cognitive impairment.Methods:This was a retrospective cross sectional study. We selected 92 consecutive patients diagnosed with Amnestic Mild Cognitive Impairment who had a comprehensive battery of neuropsychological tests and a behaviour rating scale of interest for this study recorded in the database. Correlation analysis was done to look into association between apathy and caregiver burden.Results:Apathy score was significantly related to caregiver burden in amnestic mild cognitive impairment.Conclusions:Our study has shown high association of apathy with caregiver burden in aMCI.