bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective activation of group III metabotropic glutamate receptor subtypes produces different patterns of γ‐aminobutyric acid immunoreactivity and glutamate release in the retina
Authors: Guimarães‐Souza E.M. , Calaza K.C. 
Published: September 2012

AbstractGlutamate, the major excitatory neurotransmitter in the retina, functions by activation of both ionotropic (iGluR) and metabotropic (mGluR) glutamate receptors. Group III mGluRs, except for mGluR6, are mostly found in the inner plexiform layer (IPL), and their retinal functions are not well known. Therefore, we decided to investigate the effect of mGluRIII on glutamate release and GABAergic amacrine cells in the chick retina. The nonselective mGluRIII agonist L‐SOP promoted a decrease in the number of γ‐aminobutyric acid (GABA)‐positive cells and in the GABA immunoreactivity in all sublayers of the IPL. This effect was prevented by the antagonist MAP‐4, by GAT‐1 inhibitor, and by antagonists of iGluR. Under the conditions used, L‐SOP did not alter endogenous glutamate release. VU0155041, an mGluR4‐positive allosteric modulator, reduced GABA immunoreactivity in amacrine cells and in sublayers 2 and 4 of the IPL but evoked an increase in the glutamate released. VU0155041's effect was inhibited by the absence of calcium. AMN082, a selective mGluR7‐positive allosteric modulator, also decreased GABA immunoreactivity in amacrine cells and sublayers 1, 2, and 3 and increased glutamate release, and this effect was also inhibited by calcium absence. DCPG, an mGluR8‐selective agonist, did not significantly alter GABA immunoreactivity in amacrine cells or glutamate release. However, it did significantly increase GABA immunoreactivity in sublayers 4 and 5. The results suggest that mGluRIIIs are involved in the modulation of glutamate and GABA release in the retina, possibly participating in distinct visual pathways: mGluR4 might be involved with cholinergic circuitry, whereas mGluR7 and mGluR8 might participate, respectively, in the OFF and the ON pathways. © 2012 Wiley Periodicals, Inc.
Hyperbaric oxygen treatment prevents nitric oxide‐induced apoptosis in articular cartilage injury via enhancement of the expression of heat shock protein 70
Authors: Ueng Steve W. N. , Yuan Li‐Jen , Lin Song‐Shu , Niu Chi‐Chien , Chan Yi‐Sheng , Wang I‐Chun , Yang Chuen‐Yung , Chen Wen‐Jer 
Published: September 2012

AbstractHeat shock proteins (HSPs), inflammatory cytokines, nitric oxide (NO), and localized hypoxia‐induced apoptosis are thought to be correlated to the degree of cartilage injury. We investigated the effect of hyperbaric oxygen (HBO) on (1) interleukin‐1β (IL‐1β)‐induced NO production and apoptosis of rabbit chondrocytes and (2) healing of articular cartilage defects. For the in vitro study, RT‐PCR and Western blotting were performed to detect mRNA and protein expressions of HSP70, inducible NO synthase (iNOS), and caspase 3 in IL‐1β‐treated chondrocytes. To clarify that the HSP70 was necessary for anti‐iNOS and anti‐apoptotic activity by HBO, we treated the cells with an HSP70 inhibitor, KNK437. For the in vivo study, cartilage defects were created in rabbits. The HBO group was exposed to 100% oxygen at 2.5 ATA for 1.5 h a day for 10 weeks. The control group was exposed to normal air. After sacrifice, specimen sections were sent for examination using a scoring system. Immunohistochemical analyses were performed to detect the expressions of iNOS, HSP70, and caspase 3. Our results suggested that HBO upregulated the mRNA and protein expressions of HSP70 and suppressed those of iNOS and caspase 3 in chondrocytes. KNK437 inhibited the HBO‐induced downregulation of iNOS and casapase 3 activities. The histological scores showed that HBO markedly enhanced cartilage repair. Immunohistostaining showed that HBO enhanced HSP70 expression and suppressed iNOS and caspase 3 expressions in chondrocytes. Accordingly, HBO treatment prevents NO‐induced apoptosis in articular cartilage injury via enhancement of the expression of heat shock protein 70. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 376–384, 2013
Laparoscopic pancreatectomy for malignancy
Authors: Fisher Sarah B. , Kooby David A. 
Published: September 2012

AbstractUtilization of laparoscopic techniques for resection of the pancreas has slowly gained acceptance in specific situations and is now being applied to more challenging endeavors, such as pancreaticoduodenectomy for cancer. This review provides a summary of laparoscopic applications for pancreatic malignancy, with specific attention to the most common methods of pancreatic resection and their respective oncologic outcomes, including margin status, lymph node retrieval, and survival. J. Surg. Oncol. 2013;107:39–50. © 2012 Wiley Periodicals, Inc.
Abundance of rare and elusive species: Empirical investigation of closed versus spatially explicit capture–recapture models with lynx as a case study
Authors: Blanc Laetitia , Marboutin Eric , Gatti Sylvain , Gimenez Olivier 
Published: September 2012

AbstractEffective conservation and management require reliable monitoring methods and estimates of abundance to prioritize human and financial investments. Camera trapping is a non‐invasive sampling method allowing the use of capture–recapture (CR) models to estimate abundance while accounting for the difficulty of detecting individuals in the wild. We investigated the relative performance of standard closed CR models and spatially explicit CR models (SECR) that incorporate spatial information in the data. Using simulations, we considered 4 scenarios comparing low versus high detection probability and small versus large populations and contrasted abundance estimates obtained from both approaches. Standard CR and SECR models both provided minimally biased abundance estimates, but precision was improved when using SECR models. The associated confidence intervals also provided better coverage than their non‐spatial counterpart. We concluded SECR models exhibit better statistical performance than standard closed CR models and allow for sound management strategies based on density maps of activity centers. To illustrate the comparison, we considered the Eurasian lynx (Lynx lynx) as a case study that provided the first abundance estimates of a local population in France. © 2012 The Wildlife Society.
Utility of cVEMPs in bilateral superior canal dehiscence syndrome
Authors: Niesten Marlien E.F. , McKenna Michael J. , Herrmann Barbara S. , Grolman Wilko , Lee Daniel J. 
Published: September 2012

AbstractObjectives/Hypothesis:To determine the utility of cervical vestibular evoked myogenic potential (cVEMP) thresholds in the surgical management of bilateral superior canal dehiscence syndrome (SCDS).Study design:Retrospective review.Methods:We identified patients who underwent surgical treatment for SCDS from our database of 147 patients diagnosed with superior canal dehiscence (SCD) between 2000 and 2011 at our institution. The diagnosis of SCDS was based on clinical signs and symptoms, audiometric and cVEMP testing, and high‐resolution computed tomography.Results:We identified 38 patients who underwent SCD surgery in 40 ears (2 bilateral). In seven patients with bilateral SCD, the more symptomatic ear had lower cVEMP thresholds, a larger air bone gap and a lateralizing tuning fork. In 13 patients with perioperative cVEMP testing, thresholds increased in 12 patients following primary repair, and no threshold shift was seen in one patient with persistence of symptoms after revision surgery. Audiometric data showed a significant mean decrease of the low‐frequency air‐bone gap and a mild (high‐frequency) bone conduction loss after surgical repair.Conclusions:We found that, 1) preoperative cVEMP thresholds, the magnitude of the air‐bone gap and tuning‐fork testing are important to confirm the worse ear in patients with bilateral SCD, 2) elevation of cVEMP thresholds following surgery correlates with improvement of symptoms and underscores the importance of postoperative testing in patients with bilateral disease or recurrence of symptoms and, 3) SCD plugging is associated with a partial closure of the air‐bone gap and a mild (high‐frequency) sensorineural hearing loss. Laryngoscope, 2013
Is NIH funding predictive of greater research productivity and impact among academic otolaryngologists?
Authors: Svider Peter F. , Mauro Kevin M. , Sanghvi Saurin , Setzen Michael , Baredes Soly , Eloy Jean Anderson 
Published: September 2012

AbstractObjectives/Hypothesis:The h‐index is an accurate and reliable indicator of scholarly productivity that takes into account relevance, significance, and influence of research contributions. As such, it is an effective, objective bibliometric that can be used to evaluate academic otolaryngologists for decisions regarding appointment and advancement. In this study, we evaluate the impact of NIH funding on scholarly productivity in otolaryngology.Study Design:Analysis of bibliometric data of academic otolaryngologists.Methods:Funding data for the 20 otolaryngology departments with the largest aggregate total of NIH grants for the fiscal years (FY) 2011 and 2012 was obtained using the National Institutes of Health Research Portfolio Online Reporting Tools Expenditures and Reports (RePORTER) Database. H‐indices were calculated using the Scopus online database, and then compared to funding data at both the departmental and individual level.Results:Faculty members in otolaryngology departments who received NIH funding had significantly greater research productivity and impact, as measured by the h‐index, than their nonfunded peers. H‐indices increased with greater NIH funding levels, and investigators with MD degrees tended to have higher mean NIH funding levels than those with PhDs. While there was no correlation between average h‐index and NIH funding totals at the level of departments, there was greater correlation upon examination of NIH funding levels of individual investigators.Conclusions:The h‐index has a strong relationship with, and may be predictive of, grant awards of NIH‐funded faculty members in otolaryngology departments. This bibliometric may be useful in decisions regarding appointment and advancement of faculty members within academic otolaryngology departments. Laryngoscope, 2013
What can Head‐Final Languages Tell us about Syntactic Priming (and vice versa)?
Authors: Arai Manabu 
Published: September 2012

AbstractSyntactic priming, a phenomenon that previous exposure to a particular syntactic structure makes the structure more accessible in subsequent utterances, has widely been observed in both language production and comprehension. Previous research using this paradigm revealed a great deal about processing and representations of syntactic structures. Based on previous findings, it is recently proposed that priming plays a central role in the language processing and learning system. Such a claim often presumes that syntactic priming occurs in the same way across languages. Increasing evidence demonstrates priming in many different languages but what is challenging is to establish that syntactic priming is underlain by the same mechanism across languages. Perhaps the strongest test of such a common mechanism account is to examine the phenomenon in languages that are typologically different from English and other Germanic languages on which the majority of previous studies were conducted. To address this issue, this article reviews the previous studies conducted in head‐final languages. Finding that syntactic priming occurs in a similar way between head‐final languages and head‐initial languages would provide strong support to the common mechanism of priming across languages. Although evidence is still limited, previous studies support that syntactic priming occurs in head‐final languages in a similar way and possibly by the same mechanism as in head‐initial languages. I also discuss implications of the results of those studies for the syntactic representations and processing in head‐final languages.
VPS35 mutation in Japanese patients with typical Parkinson's disease
Authors: Ando Maya , Funayama Manabu , Li Yuanzhe , Kashihara Kenichi , Murakami Yoshitake , Ishizu Nobutaka , Toyoda Chizuko , Noguchi Katsuhiko , Hashimoto Takashi , Nakano Naoki , Sasaki Ryogen , Kokubo Yasumasa , Kuzuhara Shigeki , Ogaki Kotaro , Yamashita Chikara , Yoshino Hiroyo , Hatano Taku , Tomiyama Hiroyuki , Hattori Nobutaka 
Published: September 2012

AbstractVacuolar protein sorting 35 (VPS35) was recently reported to be a pathogenic gene for late‐onset autosomal dominant Parkinson's disease (PD), using exome sequencing. To date, VPS35 mutations have been detected only in whites with PD. The aim of the present study was to determine the incidence and clinical features of Asian PD patients with VPS35 mutations. We screened 7 reported nonsynonymous missense variants of VPS35, including p.D620N, known as potentially disease‐associated variants of PD, in 300 Japanese index patients with autosomal dominant PD and 433 patients with sporadic PD (SPD) by direct sequencing or high‐resolution melting (HRM) analysis. In addition, we screened 579 controls for the p.D620N mutation by HRM analysis. The p.D620N mutation was detected in 3 patients with autosomal dominant PD (1.0%), in 1 patient with SPD (0.23%), and in no controls. None of the other reported variants of VPS35 were detected. Haplotype analysis suggested at least 3 independent founders for Japanese patients with p.D620N mutation. Patients with the VPS35 mutation showed typical tremor‐predominant PD. We report Asian PD patients with the VPS35 mutation. Although VPS35 mutations are uncommon in PD, the frequency of such mutation is relatively higher in Japanese than reported in other populations. In VPS35, p.D620N substitution may be a mutational hot spot across different ethnic populations. Based on the clinical features, VPS35 should be analyzed in patients with PD, especially autosomal dominant PD or tremor‐predominant PD. © 2012 Movement Disorder Society
Effects of surface modification of carbon nanotube on platinum nanoparticle deposition using supercritical carbon dioxide fluid
Authors: Watanabe Mitsuhiro , Akimoto Tatsunori , Kondoh Eiichi 
Published: September 2012

AbstractPlatinum nanoparticles were fabricated on multiwalled carbon nanotubes (MWCNTs) by using supercritical fluid deposition. In this technique, deposition was carried out in a supercritical carbon dioxide fluid via hydrogen reduction of a dissolved platinum complex. The deposition temperature and deposition‐time dependences on the particle size and density were investigated. The obtained metallic nanoparticles/MWCNT nanocomposites were characterized by using transmission electron microscopy and scanning transmission electron microscopy. Crystalline pure platinum nanoparticles were clearly observed on the surfaces of MWCNTs. Most of the particles observed were smaller than 5 nm in diameter. The density of the particles increased with temperature between 393 and 423 K and decreased above 423 K. The nucleation of the nanoparticles took place within a deposition time of 60 min, and then agglomeration and coarsening occurred, resulting in an increase of the particle size. It was found that the surface topography of the carbon support greatly influences the platinum nucleation density. Indeed, when the MWCNTs were treated with hydrogen plasma prior to platinum deposition, the density of the nanoparticles markedly increased. The impact of the hydrogen plasma treatment on the particle‐size dependences was also investigated.
Bonding and optical contrast in phase change memory materials
Authors: Robertson J. , Huang B. 
Published: September 2012

AbstractThe large optical contrast between crystalline and amorphous phases of phase change memory materials is shown to arise from a large increase in the optical matrix elements which occurs when resonant bonding is present. Resonance requires aligned p orbitals, and is lost in the amorphous phases, irrespective of coordination number. Transitions in resonance can be engineered by superlattice structures.
High‐gain observers for leak location in subterranean pipelines of liquefied petroleum gas
Authors: Torres L. , Verde C. , Besançon G. , González O. 
Published: September 2012

SUMMARYThis paper describes a scheme based on high‐gain observers to detect and locate leaks in subterranean pipelines of liquefied petroleum gas (LPG). In fact, sub‐observers connected in cascade are used to generate residuals that allow to detect when a leak occurs and, above all, to isolate the region of the pipeline where the leak is located. Once the region is identified, a dedicated observer is employed to more precisely estimate the leak position as well as its coefficient. The approach is validated with data from a real industrial LPG pipeline. Copyright © 2012 John Wiley & Sons, Ltd.
Fault detection and isolation for networked control systems with finite frequency specifications
Authors: Long Yue , Yang Guang‐Hong 
Published: September 2012

SUMMARYThe fault detection and isolation (FDI) problem with finite frequency specifications is addressed in this paper under the framework of geometric approach for networked control systems subject to communication constraints and packet losses. The considered communication constraint is that only one of the transmission nodes is allowed to gain access to the shared channel. Also, those transmission nodes are scheduled to transmit data according to a specified stochastic protocol. Then by virtues of the common unobservable subspace and the finite frequency stochastic H −  index, a novel FDI scheme is developed in which a set of FDI filters that perform the FDI task with only partially available measurements are designed such that each residual is only sensitive to one fault in certain frequency domain and decoupled from the others. Further, less conservative conditions including some previous existing results have been presented to construct the FDI filters. Finally, an example is given to illustrate the effectiveness of the proposed method.Copyright © 2012 John Wiley & Sons, Ltd.
Cisterna magna width at 11–13 weeks in the detection of posterior fossa anomalies
Authors: Garcia‐Posada R. , Eixarch E. , Sanz M. , Puerto B. , Figueras F. , Borrell A. 
Published: September 2012

ABSTRACTObjectiveTo construct reference ranges for cisterna magna (CM) width at 11–13 weeks' gestation in healthy fetuses and determine whether open spina bifida and posterior fossa anomalies could be diagnosed in the first trimester.MethodsThis was a retrospective study. CM width reference ranges were constructed based on the measurements obtained from 80 healthy fetuses with normal postnatal outcome undergoing routine first‐trimester ultrasound at 11–13 weeks, using the Lambda‐Mu‐Sigma method. CM was measured in the fetal mid‐sagittal view, as routinely used for nuchal translucency assessment. In addition, first‐trimester ultrasound images in 11 fetuses with open spina bifida or posterior fossa anomalies, most of which were diagnosed later in pregnancy, were retrospectively reviewed, and CM measurements were compared against reference ranges.ResultsCM width was noted to increase with gestational age in normal fetuses. The anomalies in the 11 fetuses we reviewed were: open spina bifida (n = 5), megacisterna magna (n = 3), Blake's pouch cyst (n = 2) and posterior fossa arachnoid cyst (n = 1). All fetuses with open spina bifida had a CM width below the 5th percentile. In the two fetuses with Blake's pouch cyst and in two with megacisterna magna, CM width was above the 95th percentile. In one of the fetuses with a megacisterna magna and the one with an arachnoid cyst, CM width was within normal range.ConclusionWe have constructed reference ranges for CM width at 11–13 weeks using the mid‐sagittal view. It appears that first‐trimester CM width can be used as a marker for the early detection of open spina bifida. However, our findings need to be confirmed in prospective large series. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Classification and discrimination of some cosmetic face powders using XRF spectrometry with chemometric data analysis
Authors: Kulikov Elizabeth , Latham Kay , Adams Michael J. 
Published: September 2012

Cosmetic foundation powders are one of the most commonly used cosmetic products in modern society. In recent years, the so‐called mineral‐based foundation products have become increasing popular in the cosmetic consumer market and can demand a premium price from the consumer. Manufacturers and suppliers often refer to mineral foundations as being ‘chemical free’, implying that these materials contain no potential skin irritants. However, there are no laws determining the use of the term ‘mineral cosmetic’ and interpretation of the use of the term is at the discretion of the manufacturer.In this study, wavelength‐dispersive X‐ray fluorescence spectrometry has been employed for multi‐elemental analysis of 39 mineral and traditional ingredient cosmetic powders. Quantitative measurements were obtained for Al, Bi, Ca, Fe, K, Mg, Si, Ti and Zn. Using cluster analysis and principal components analysis, we could clearly identify the samples as being of traditional or mineral formulation, and in the case of the mineral samples, specific manufacturers could be distinguished. Of the samples examined, samples from two suppliers marketed as mineral‐based were determined as being indistinguishable from traditional formulations. Copyright © 2012 John Wiley & Sons, Ltd.
Clinical and biochemical features associated with BCS1L mutation
Authors: Al‐Owain Mohammed , Colak Dilek , Albakheet Albandary , Al‐Younes Banan , Al‐Humaidi Zainab , Al‐Sayed Moeen , Al‐Hindi Hindi , Al‐Sugair Abdulaziz , Al‐Muhaideb Ahmed , Rahbeeni Zuhair , Al‐Sehli Abdullah , Al‐Fadhli Fatima , Ozand Pinar T. , Taylor Robert W. , Kaya Namik 
Published: September 2012

AbstractOur study describes a novel phenotype in a series of nine Saudi patients with lactic acidosis, from four consanguineous families three of which are related. Detailed genetic studies including linkage, homozygosity mapping and targeted sequencing identified a causative mutation in the BCS1L gene. All affected members of the families have an identical mutation in this gene, mutations of which are recognized causes of Björnstad syndrome, GRACILE syndrome and a syndrome of neonatal tubulopathy, encephalopathy, and liver failure (MIM 606104) leading to isolated mitochondrial respiratory chain complex III deficiency. Here we report the appearance of a novel behavioral (five patients) and psychiatric (two patients) phenotype associated with a p.Gly129Arg BCS1L mutation, differing from the phenotype in a previously reported singleton patient with this mutation. The psychiatric symptoms emanated after childhood, initially as hypomania later evolving into intermittent psychosis. Neuroradiological findings included subtle white matter abnormalities, whilst muscle histopathology and respiratory chain studies confirmed respiratory chain dysfunction. The variable neuro‐psychiatric manifestations and cortical visual dysfunction are most unusual and not reported associated with other BCS1L mutations. This report emphasizes the clinical heterogeneity associated with the mutation in BCS1L gene, even within the same family and we recommend that defects in this gene should be considered in the differential diagnosis of lactic acidosis with variable involvement of different organs.