bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates
Authors: Di Florio A. , Craddock N. , van den Bree M. 
Published: September 2013

AbstractAims:To assess the comorbidity rates of alcohol use disorders (AUDs) in bipolar disorder (BD) and to explore possible sources of heterogeneity.Methods:Studies were identified through database searches. Meta-analytic techniques were employed to aggregate data on lifetime comorbidity and to explore possible sources of heterogeneity. Funnel plots were used to detect publication bias.Results:In clinical studies, AUDs affected more than one in three subjects with BD. Significant heterogeneity was found, which was largely explained by the geographical location of study populations and gender ratio of participants. AUDs affected more than one in five women and two in five men.Conclusion:AUDs are highly prevalent in BD. Our study revealed a substantial heterogeneity across studies. Further research including control groups is needed. Patients with BD should be assessed for current and previous AUDs.
Hamburg Center for Health Economics
Authors: Schreyögg Jonas , Mitglieder des Hamburg Center for Health Economics  
Published: September 2013

Einleitung
Die Universität Hamburg und das Universitätsklinikum Hamburg-Eppendorf (UKE) gründeten 2010 das Hamburg Center for Health Economics (HCHE). Ziel ist die Anwendung und Weiterentwicklung von empirischen und theoretischen Methoden der Gesundheitsökonomie. Das Zentrum besteht aus sechs gesundheitsökonomischen Lehrstühlen, zwei Juniorprofessuren und zwei Nachwuchsgruppen. Für den weiteren Ausbau erhält das HCHE als eines von vier gesundheitsökonomischen Zentren in Deutschland eine Förderung des Bundesministeriums für Bildung und Forschung (BMBF).
Training tomorrow's laryngologists – head and neck training alone is not sufficient
Authors: De Zoysa N , Amin N , Harries M 
Published: September 2013

AbstractBackground:Diagnostic ability is essential in laryngology. The UK Higher Surgical Training syllabus includes competencies specific to laryngology. This study aimed to identify the factors in training that lead to a consultant level of laryngology-related diagnostic ability.Method:An online test of training experience was constructed using laryngoscopy videos obtained from a specialist UK voice clinic. Participation was aimed at both trainees and trainers via invitation through national ENT forums.Results:There were 51 complete responses. Trainees with six months of laryngology experience scored significantly higher than those without this experience (p < 0.001). There was no improvement in score demonstrated for those with head and neck specialty experience without laryngology experience. Trainees who had completed 12 months of laryngology, or 6 months of laryngology coupled with 12 months of head and neck training, scored similarly to their consultant trainers.Conclusion:It is recommended that all trainees have at least six months of experience in a specialist voice or laryngology placement prior to gaining the Certificate of Completion of Training.
An epidemiological investigation ofCampylobacterin pig and poultry farms in the Mekong delta of Vietnam
Authors: CARRIQUE-MAS J. J. , BRYANT J. E. , CUONG N. V. , HOANG N. V. M. , CAMPBELL J. , HOANG N. V. , DUNG T. T. N. , DUY D.T. , HOA N. T. , THOMPSON C. , HIEN V. V. , PHAT V. V. , FARRAR J. , BAKER S. 
Published: September 2013

SUMMARYCampylobacterare zoonotic pathogens commonly associated with gastroenteritis. To assess the relevance ofCampylobacterin Vietnam, an economically transitioning country in SE Asia, we conducted a survey of 343 pig and poultry farms in the Mekong delta, a region characterized by mixed species farming with limited biosecurity. The animal-level prevalence ofCampylobacterwas 31·9%, 23·9% and 53·7% for chickens, ducks and pigs, respectively.C. jejuniwas predominant in all three host species, with the highest prevalence in pigs in high-density production areas.Campylobacterisolates demonstrated high levels of antimicrobial resistance (21% and 100% resistance against ciprofloxacin and erythromycin, respectively). Multilocus sequence type genotyping showed a high level of genetic diversity withinC. jejuni, and predictedC. coliinter-species transmission. We suggest that on-going intensification of animal production systems, limited biosecurity, and increased urbanization in Vietnam is likely to result inCampylobacterbecoming an increasingly significant cause of human diarrhoeal infections in coming years.
Are the children and adolescents with congenital heart disease living in Southwestern Ontario really overweight and obese?
Authors: Welisch Eva , Rauch Ralf , Seabrook Jamie A. , Filler MA Guido , Norozi Kambiz 
Published: September 2013

AbstractObjectiveTo assess the prevalence of overweight and obesity in children with congenital heart disease and compare them with age-matched healthy children in Southwestern Ontario, Canada.MethodsWe compared the Center of Disease Control weight and body mass index z-scores of 1080 children, aged 2 to 18 years, who presented to our paediatric cardiology outpatient clinic from 2008 to 2010 for congenital heart disease with 1083 healthy controls.ResultsIn all, 18.2% of the children with congenital heart disease and 20.8% of healthy children were identified to be either overweight or obese. Overall, the weight category distribution had been similar between the congenital heart disease and healthy control groups, as well as between the congenital heart disease subgroups. There was no difference in normal weight and overweight/obese categories between children with congenital heart disease and healthy children. The underweight category, however, showed a significantly higher prevalence in congenital heart disease compared with healthy children (6.8 and 4.5%, respectively, p = 0.03).ConclusionThe prevalence of overweight/obesity did not differ in children with congenital heart disease compared with age-matched healthy children; however, it is still high (18.2%). Obesity may represent an additional risk factor for the long-term cardiovascular health of congenital heart disease patients aside from the underlying heart defect.
Does sport have a protective effect against suicide?
Authors: Müller Bettina , Georgi Klaus , Schnabel Axel , Schneider Barbara 
Published: September 2013

SUMMARYAim – The association between sporting activities, or lack there of, and suicidal behaviour has not yet been clarified. The objective of this study was to determine, if sports participation has an impact on risk for completed suicide. Methods – Axis I and Axis II disorders, sociodemographic factors, and current and former sports activities, including various sports disciplines, were assessed by a semi-structured interview by psychological autopsy method in 163 suicides and by personal interview in 396 living population-based control persons. Results – Current sports activities (OR = 0.24, 95%CI, 0.15 to 0.39; OR = 0.27, 95%CI, 0.16 to 0.45) and sports activities at some point in life (OR = 0.33, 95%CI, 0.18 to 0.62; OR = 0.40, 95%CI, 0.23 to 0.68, after adjustment for axis I and II disorders or educational level, each) were associated with decreased suicide risk. Conclusions – Current sports activities and sports activities at some point in life may reduce suicide risk.Declaration of Interest: Barbara Schneider got research funding as young scientist for the project “Psychopathological, sociodemographic, psychosocial, and work-related risk factors for suicide” from the faculty representative committee of the Faculty of Medicine, Johann Wolfgang Goethe-University of Frankfurt/Main. Furthermore, “Nachlaβ Martha Schmelz”, part of the university foundation of Frankfurt am Main, supported the research project. There was no support from drug companies related to the present paper. Barbara Schneider, Klaus Georgi, and Axel Schnabel are employed at the Goethe-University Hospital and Faculty of Medicine. Bettina Müller is employed at the Markus Hospital, Frankfurt /Main.
The Content and the Form in Amīr Khusraw'sDuval Rānī va Khiẓr Khān
Authors: BEDNAR MICHAEL BORIS 
Published: September 2013

AbstractModern scholars approach Amīr Khusraw'sDuval Rānī va Khiẓr Khānas either a historicalmaavīthat relates Delhi Sultanate conquests or as a romanticmaavīthat combines the love story between the crown prince and a Hindu princess with tragedy resulting from their fate. While the content of theDuval Rānī va Khiẓr Khānis well known, the form of the text and its implications for reading both history and romance remains unexplored. Reading the form inverts the historic and romantic division of the text. It reveals the historical elements as romantic panegyric created by Khusraw in praise of the Delhi Sultanate and the romance as a source-based historical biography.
Minimal intervention strategies in logical signaling networks with ASP
Authors: KAMINSKI ROLAND , SCHAUB TORSTEN , SIEGEL ANNE , VIDELA SANTIAGO 
Published: September 2013

AbstractProposing relevant perturbations to biological signaling networks is central to many problems in biology and medicine because it allows for enabling or disabling certain biological outcomes. In contrast to quantitative methods that permit fine-grained (kinetic) analysis, qualitative approaches allow for addressing large-scale networks. This is accomplished by more abstract representations such as logical networks. We elaborate upon such a qualitative approach aiming at the computation of minimal interventions in logical signaling networks relying on Kleene's three-valued logic and fixpoint semantics. We address this problem within answer set programming and show that it greatly outperforms previous work using dedicated algorithms.
The problem of dinosaur origins: integrating three approaches to the rise of Dinosauria
Authors: Padian Kevin 
Published: September 2013

ABSTRACTThe problem of the origin of dinosaurs has historically had three dimensions. The first is the question of whether Dinosauria is monophyletic, and of its relationships to other archosaurs. This question was plagued from the beginning by a lack of relevant fossils, an historical burden of confusing taxonomic terms and a rudimentary approach to devising phylogenies. The second dimension concerns the functional and ecological adaptations that differentiated dinosaurs from other archosaurs, a question also marred by lack of phylogenetic clarity and testable biomechanical hypotheses. The third dimension comprises the stratigraphic timing of the origin of dinosaurian groups with respect to each other and to related groups, the question of its synchronicity among various geographic regions, and some of the associated paleoenvironmental circumstances. None of these dimensions alone answers the question of dinosaur origins, and they sometimes provide conflicting implications. Since Dinosauria was named, one or another set of questions has historically dominated academic discussion and research. Paradigms have shifted substantially in recent decades, and current evidence suggests that we are due for more such shifts. I suggest two changes in thinking about the beginning of the “Age of Dinosaurs”: first, the event that we call the (phylogenetic) origin of dinosaurs was trivial compared to the origin of Ornithodira; and second, the “Age of Dinosaurs” proper did not begin until the Jurassic. Re-framing our thinking on these issues will improve our understanding of clade dynamics, timing of macroevolutionary events, and the effects of Triassic climate change on terrestrial vertebrates.
Power electronic configuration for the operation of PV system in combined grid‐connected and stand‐alone modes
Authors: Krithiga Subramanian , Gounden Nanjappa Gounder Ammasai 
Published: September 2013

A simple photovoltaic (PV) system capable of operating in both grid‐connected mode and stand‐alone mode using multilevel boost converter (MBC) and line commutated inverter (LCI) has been developed for extracting the maximum power and feeding it to a single phase utility grid and stand‐alone system simultaneously. Theoretical analysis of the proposed system is done and the duty ratio of the MBC is estimated for extracting maximum power from PV array. For a fixed firing angle of LCI, the proposed system is able to track the maximum power with the determined duty ratio which remains the same for all irradiations. This is the major advantage of the proposed system which eliminates the use of a separate maximum power point tracking (MPPT) controller. Experiments have been conducted on a 80 V, 9.4 A PV array feeding a 110 V single phase grid and a 230 V, 100 W DC motor. The MBC extracts maximum power from the PV array and feeds the major portion of power to the single phase utility grid via LCI and the remaining power to separately excited DC motor. It was found that the theoretical analysis, simulation and experimental results closely correlate with each other and proves the effectiveness of the proposed configuration.
Magnetic and electronic properties of bimagnetic materials comprising cobalt particles within hollow silica decorated with magnetite nanoparticles
Authors: Okada T. , González-Alfaro Y. , Espinosa A. , Watanabe N. , Haeiwa T. , Sonehara M. , Mishima S. , Sato T. , Muñoz-Noval A. , Aranda P. , Garcia-Hernández M. , Ruiz-Hitzky E. 
Published: September 2013

Bimagnetic materials were fabricated by decorating the external surface of rattle-type hollow silica microspheres (which themselves contain metallic cobalt nanoparticles) with magnetite nanoparticles; thus, each magnetic substance was spatially isolated by the silica shell. The amount of magnetite decoration on the co-occluded hollow silica was varied from 1 to 17 mass %. Magnetic and electronic properties of the resulting bimagnetic materials were characterized by superconducting quantum interference device measurements and X-ray absorption spectroscopy, respectively. The ferrous iron in the bimagnetic sample was slightly more oxidized than in the magnetite reference, probably from some charge-transfer because of the SiO2 surface contact, although the overall oxidation state of the samples is very similar to that of magnetite. The temperature dependence of the sample magnetization recorded with Zero Field Cooling and Field Cooling resulted in blocking temperatures for the bimagnetic materials that were close to that of magnetite nanoparticles (176 K) and were lower than that for the bare Co-occluded hollow silica (which was above room temperature). Values of coercive force and exchange bias at 300 K became quite small after decoration with only minimal amounts of magnetite nanoparticles (1–3 mass %) and were lower than those of magnetite. This is the first example of enhancing superparamagnetism by spatial separation of both Co and magnetite magnetic nanoparticles using a thin wall of diamagnetic silica.
Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3
Authors: Bajic Goran , Yatime Laure , Sim Robert B. , Vorup-Jensen Thomas , Andersen Gregers R. 
Published: September 2013

SignificanceFragments of complement component C3 tag surfaces such as those presented by microbial pathogens or dying host cells for recognition by cells from the innate immune system. Complement receptor (CR) 3 enables efficient binding of complement-tagged surfaces by macrophages and dendritic cells, which eventually transport the CR3-bound material into lymph nodes. The study identifies in atomic details the fragments of CR3 and C3 required for such binding. The structural organization permits concomitant recognition by another complement receptor, namely CR2, expressed on cells of the adaptive immune system, suggesting a structural rationale for the exchange of antigens between leukocytes of the innate and adaptive immune systems critical in the formation of humoral immune responses.
Trust: A Very Short Introduction
Authors: Hawley Katherine 
Published: September 2013

Abstract
Trust: A Very Short Introduction explores key ideas about trust and distrust. Trust is indispensable, yet it can be damaging. Without trusting others, we cannot function in society, or even stay alive for very long, but being overly-trustful can also be a bad strategy. Trust is pragmatic, but it also has a moral dimension: trustworthiness is a virtue, and well-placed trust benefits us all. Why do we value trust? Why do we want to be trusted? Trust is important both in the personal and public spheres, including in family and relationships as well as politics and society.
BSeQC: quality control of bisulfite sequencing experiments
Authors: Lin Xueqiu , Sun Deqiang , Rodriguez Benjamin , Zhao Qian , Sun Hanfei , Zhang Yong , Li Wei 
Published: September 2013

Abstract
Motivation: Bisulfite sequencing (BS-seq) has emerged as the gold standard to study genome-wide DNA methylation at single-nucleotide resolution. Quality control (QC) is a critical step in the analysis pipeline to ensure that BS-seq data are of high quality and suitable for subsequent analysis. Although several QC tools are available for next-generation sequencing data, most of them were not designed to handle QC issues specific to BS-seq protocols. Therefore, there is a strong need for a dedicated QC tool to evaluate and remove potential technical biases in BS-seq experiments.
Results: We developed a package named BSeQC to comprehensively evaluate the quality of BS-seq experiments and automatically trim nucleotides with potential technical biases that may result in inaccurate methylation estimation. BSeQC takes standard SAM/BAM files as input and generates bias-free SAM/BAM files for downstream analysis. Evaluation based on real BS-seq data indicates that the use of the bias-free SAM/BAM file substantially improves the quantification of methylation level.
Availability and implementation: BSeQC is freely available at: http://code.google.com/p/bseqc/.
Contact: wl1@bcm.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells
Authors: Fisher Ciarán P. , Plant Nicholas J. , Moore J. Bernadette , Kierzek Andrzej M. 
Published: September 2013

Abstract
Motivation: Dynamic simulation of genome-scale molecular interaction networks will enable the mechanistic prediction of genotype–phenotype relationships. Despite advances in quantitative biology, full parameterization of whole-cell models is not yet possible. Simulation methods capable of using available qualitative data are required to develop dynamic whole-cell models through an iterative process of modelling and experimental validation.
Results: We formulate quasi-steady state Petri nets (QSSPN), a novel method integrating Petri nets and constraint-based analysis to predict the feasibility of qualitative dynamic behaviours in qualitative models of gene regulation, signalling and whole-cell metabolism. We present the first dynamic simulations including regulatory mechanisms and a genome-scale metabolic network in human cell, using bile acid homeostasis in human hepatocytes as a case study. QSSPN simulations reproduce experimentally determined qualitative dynamic behaviours and permit mechanistic analysis of genotype–phenotype relationships.
Availability and implementation: The model and simulation software implemented in C++ are available in supplementary material and at http://sysbio3.fhms.surrey.ac.uk/qsspn/.
Contact: a.kierzek@surrey.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.
The BRASSINOSTEROID INSENSITIVE1–LIKE3 Signalosome Complex Regulates Arabidopsis Root Development
Authors: Fàbregas Norma , Li Na , Boeren Sjef , Nash Tara E. , Goshe Michael B. , Clouse Steven D. , de Vries Sacco , Caño-Delgado Ana I. 
Published: September 2013

Abstract
Brassinosteroid (BR) hormones are primarily perceived at the cell surface by the leucine-rich repeat receptor-like kinase BRASSINOSTEROID INSENSITIVE1 (BRI1). In Arabidopsis thaliana, BRI1 has two close homologs, BRI1-LIKE1 (BRL1) and BRL3, respectively, which are expressed in the vascular tissues and regulate shoot vascular development. Here, we identify novel components of the BRL3 receptor complex in planta by immunoprecipitation and mass spectrometry analysis. Whereas BRI1 ASSOCIATED KINASE1 (BAK1) and several other known BRI1 interactors coimmunoprecipitated with BRL3, no evidence was found of a direct interaction between BRI1 and BRL3. In addition, we confirmed that BAK1 interacts with the BRL1 receptor by coimmunoprecipitation and fluorescence microscopy analysis. Importantly, genetic analysis of brl1 brl3 bak1-3 triple mutants revealed that BAK1, BRL1, and BRL3 signaling modulate root growth and development by contributing to the cellular activities of provascular and quiescent center cells. This provides functional relevance to the observed protein–protein interactions of the BRL3 signalosome. Overall, our study demonstrates that cell-specific BR receptor complexes can be assembled to perform different cellular activities during plant root growth, while highlighting that immunoprecipitation of leucine-rich repeat receptor kinases in plants is a powerful approach for unveiling signaling mechanisms with cellular resolution in plant development.
An Arabidopsis Soil-Salinity–Tolerance Mutation Confers Ethylene-Mediated Enhancement of Sodium/Potassium Homeostasis
Authors: Jiang Caifu , Belfield Eric J. , Cao Yi , Smith J. Andrew C. , Harberd Nicholas P. 
Published: September 2013

Abstract
High soil Na concentrations damage plants by increasing cellular Na accumulation and K loss. Excess soil Na stimulates ethylene-induced soil-salinity tolerance, the mechanism of which we here define via characterization of an Arabidopsis thaliana mutant displaying transpiration-dependent soil-salinity tolerance. This phenotype is conferred by a loss-of-function allele of ETHYLENE OVERPRODUCER1 (ETO1; mutant alleles of which cause increased production of ethylene). We show that lack of ETO1 function confers soil-salinity tolerance through improved shoot Na/K homeostasis, effected via the ETHYLENE RESISTANT1–CONSTITUTIVE TRIPLE RESPONSE1 ethylene signaling pathway. Under transpiring conditions, lack of ETO1 function reduces root Na influx and both stelar and xylem sap Na concentrations, thereby restricting root-to-shoot delivery of Na. These effects are associated with increased accumulation of RESPIRATORY BURST OXIDASE HOMOLOG F (RBOHF)–dependent reactive oxygen species in the root stele. Additionally, lack of ETO1 function leads to significant enhancement of tissue K status by an RBOHF-independent mechanism associated with elevated HIGH-AFFINITY K+ TRANSPORTER5 transcript levels. We conclude that ethylene promotes soil-salinity tolerance via improved Na/K homeostasis mediated by RBOHF-dependent regulation of Na accumulation and RBOHF-independent regulation of K accumulation.