bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition deficits in individuals with intellectual disability: a meta‐regression analysis
Authors: Bexkens A. , Ruzzano L. , Collot d' Escury‐Koenigs A. M. L. , Van der Molen M. W. , Huizenga H. M. 
Published: July 2013

AbstractBackgroundIndividuals with intellectual disabilities (ID) are characterised by inhibition deficits; however, the magnitude of these deficits is still subject to debate. This meta‐analytic study therefore has two aims: first to assess the magnitude of inhibition deficits in ID, and second to investigate inhibition type, age, IQ and the presence/absence of comorbid problems as potential moderators of effect sizes.MethodTwenty‐eight effect sizes comparing ID and age matched normal controls on inhibition tasks were included in a random effects meta‐regression. Moderators were age, IQ, inhibition type and presence/absence of comorbid disorder.ResultsThe analysis showed a medium to large inhibition deficit in ID. Inhibition type significantly moderated effect size, whereas age and comorbid disorder did not. IQ significantly moderated effect size indicating increasing effect size with decreasing IQ, but only in studies that included a sample of ID participants with mean IQ > 70. The analysis indicated comparable deficits in behavioural inhibition and interference control, but no significant deficits in cognitive inhibition and motivational inhibition.ConclusionsThese results indicate that ID is characterised by a medium to large inhibition deficit in individuals with ID. ID seems not to be characterised by deficits in cognitive and motivational inhibition, which might indicate that distinct processes underlie distinct inhibition capacities.
A Comparison of Two Soldering Techniques on the Misfit of Bar‐Retained Implant‐Supported Overdentures
Authors: Alvarez Angel , Lafita Pedro , de Llanos Hector , Gago Angel , Brizuela Aritza , Ellacuria Joseba J. 
Published: July 2013

AbstractPurposeThis study was conducted to measure and compare the effect of the soldering method (torch soldering or ceramic furnace soldering) used for soldering bars to bar‐retained, implant‐supported overdentures on the fit between the bar gold cylinder and implant transgingival abutment.Materials and MethodsThirty‐two overdenture implant bars were manufactured and screw retained into two Bränemark implants, which were attached to a cow rib. The bars were randomly distributed in two groups: a torch‐soldering group and a porcelain‐furnace soldering group. Then all bars were cut and soldered using a torch and a ceramic furnace. The fit between the bar gold cylinders and implant transgingival abutments was measured with a light microscope on the opposite side to the screw tightening side before and after the bar soldering procedure. The data obtained were statistically processed for paired and independent data.ResultsThe average misfit for all bars before soldering was 33.83 to 54.04 μm. After cutting and soldering the bars, the misfit increased up to a range of 71.74 to 78.79 μm. Both before and after the soldering procedure, the bars soldered using a torch showed a higher misfit when compared to the bars soldered using a porcelain furnace. After the soldering procedure, the misfit was slightly lower on the left side of the bars, which had been soldered using a ceramic furnace.ConclusionsAccording to our data, the soldering of bars using the torch or furnace oven soldering techniques does not improve the misfit of one‐piece cast bars on two implants. The lower misfit was obtained using the porcelain furnace soldering technique.
Agreement of the Serum Spec fPL™ and 1,2‐O‐Dilauryl‐Rac‐Glycero‐3‐Glutaric Acid‐(6′‐Methylresorufin) Ester Lipase Assay for the Determination of Serum Lipase in Cats with Suspicion of Pancreatitis
Authors: Oppliger S. , Hartnack S. , Riond B. , Reusch C.E. , Kook P.H. 
Published: July 2013

BackgroundSerum lipase activities measured by catalytic assays are claimed to be of limited utility for diagnosing pancreatitis in cats. The Spec fPL assay currently is believed the most sensitive test; however, studies comparing different lipase assays are lacking. 1,2‐o‐dilauryl‐rac‐glycero‐3‐glutaric acid‐(6′‐methylresorufin) ester (DGGR) assay for the determination of lipase activity has been evaluated in dogs, but no information is available in cats.ObjectivesTo investigate the agreement of DGGR‐lipase activity and Spec fPL concentration in cats with clinical signs consistent with pancreatitis.AnimalsTwo hundred fifty‐one client‐owned cats.MethodsDGGR‐lipase activity and Spec fPL concentration measured from the same blood sample in cats undergoing investigation for pancreatitis. The agreement between DGGR‐lipase and Spec fPL at different cutoffs was assessed using Cohen's kappa coefficient (κ). Sensitivity and specificity were calculated for 31 cases where pancreatic histopathology was available.ResultsDGGR‐lipase (cutoff, 26 U/L) and Spec fPL (cutoff, >5.3 μg/L) had a κ of 0.68 (standard error [SE] 0.046). DGGR‐lipase (cutoff, 26 U/L) and Spec fPL (cutoff, >3.5 μg/L) had a κ of 0.60 (SE, 0.05). The maximum κ at a Spec fPL cutoff >5.3 μg/L was found when the DGGR‐lipase cutoff was set >34 U/L and calculated as 0.755 (SE, 0.042). Sensitivity and specificity were 48% and 63% for DGGR‐lipase (cut‐off, 26 U/L) and 57% and 63% for Spec fPL (>5.3 μg/L), respectively.Conclusions and Clinical ImportanceBoth lipase assays agreed substantially. DGGR assay seems a useful and cost‐efficient method compared to the Spec fPL test.
Jasmonate induction of the monoterpene linalool confers resistance to rice bacterial blight and its biosynthesis is regulated by JAZ protein in rice
Authors: TANIGUCHI SHIDUKU , HOSOKAWA‐SHINONAGA YUMI , TAMAOKI DAISUKE , YAMADA SHOKO , AKIMITSU KAZUYA , GOMI KENJI 
Published: July 2013

AbstractJasmonic acid (JA) is involved in the regulation of host immunity in plants. Recently, we demonstrated that JA signalling has an important role in resistance to rice bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) in rice. Here, we report that many volatile compounds accumulate in response to exogenous application of JA, including the monoterpene linalool. Expression of linalool synthase was up‐regulated by JA. Vapour treatment with linalool induced resistance to Xoo, and transgenic rice plants overexpressing linalool synthase were more resistance to Xoo, presumably due to the up‐regulation of defence‐related genes in the absence of any treatment. JA‐induced accumulation of linalool was regulated by OsJAZ8, a rice jasmonate ZIM‐domain protein involving the JA signalling pathway at the transcriptional level, suggesting that linalool plays an important role in JA‐induced resistance to Xoo in rice.
Effects of hematocrit and red blood cell–independent viscosity on canine thromboelastographic tracings
Authors: Brooks Aimee C. , Guillaumin Julien , Cooper Edward S. , Couto C. Guillermo 
Published: July 2013

BackgroundIt is well established that hematocrit (Hct) influences whole blood thromboelastography (TEG) tracings. Previous studies showed hypercoagulable TEG tracings in anemic patients despite clinical expectations that anemia often prolongs bleeding. TEG is a viscoelastic assessment of clot kinetics, and Hct is the main determinant of whole blood viscosity. TEG changes in anemia may be an in vitro artifact due to Hct effect on blood viscosity rather than true in vivo changes in hemostasis. The effect of changes in whole blood viscosity on TEG independent of Hct is not well understood.Study Design and MethodsTwenty‐one blood samples from seven dogs were manipulated to produce one of three Hct conditions (45, 20, and 10%). Each was tested in two situations: viscosity adjusted to normal by adding alginate (ALG) or dilution with equal volume of saline (SAL). Both samples were analyzed with TEG simultaneously.ResultsTwenty percent Hct plus ALG and 10% Hct plus ALG were significantly more viscous than their SAL counterparts (p = 0.0156). Ten percent Hct plus SAL, 20% Hct plus SAL, and 45% Hct plus SAL all had different viscosities (p = 0.006). Twenty percent Hct plus SAL and 10% Hct plus SAL had significantly shorter K and higher angle, MA, and G compared to their ALG counterparts as well as 45% Hct plus SAL (p < 0.05).ConclusionsALG samples with low Hct, normal viscosity showed hypocoagulable tracings, whereas SAL samples with low Hct, low viscosity showed hypercoagulable tracings. TEG variables are influenced by whole blood viscosity altered with ALG, independently of Hct.
Research on Ultrasonic Inspection of Cast Austenitic Stainless Steel Piping
Authors: Sakamoto Kazunobu , Furukawa Takashi , Komura Ichiro , Kamiyama Yoshinori , Mihara Tsuyoshi 
Published: July 2013

Japan Nuclear Energy Safety Organization (JNES) has been carrying out the research program entitled “Nondestructive Inspection Technologies for the Cast Stainless Steel Piping” since 2009FY to comprehend the unique ultrasonic wave propagation in the Cast Austenitic Stainless Steel (CASS) and to confirm detection and sizing capability for cracks in the material by currently available ultrasonic testing techniques. The research is also intended to provide inspection staff with the fundamental information of ultrasonic wave propagation in CASS, for educational purpose.
In this research program, specimens whose material, size, dimension and welding method are identical to the main coolant piping system in Japanese pressurized water reactors (PWRs) are examined. Results from the study on the capability for inspection of CASS and the unique wave propagation phenomena such as beam skewing are discussed in this paper.
Fatigue Life of the Strain Hardened Austenitic Stainless Steel in Simulated PWR Primary Water
Authors: Tsutsumi Kazuya , Huin Nicolas , Couvant Thierry , Henaff Gilbert , Mendez Jose , Chollet Denis 
Published: July 2013

Over the last 20 years or so, many studies have revealed the deleterious effect of the environment on fatigue life of austenitic stainless steels in pressurized water reactor (PWR) primary water. The fatigue life correlation factor, so-called Fen, has been standardized to consider the effect on fatigue life evaluation. The formulations are function of strain rate and temperature due to their noticeable negative effect compared with other factors [1,2]. However, mechanism causing fatigue life reduction remains to be cleared.
As one of possible approaches to examine underlying mechanism of environmental effect, the authors focused on the effect of plastic strain, because it could lead microstructural evolution on the material. In addition, in the case of stress corrosion cracking (SCC), it is well known that the strain-hardening prior to exposure to the primary water can lead to remarkable increase of the susceptibility to cracking [3,4]. However, its effect on fatigue life has not explicitly been investigated yet.
The main effort in this study addressed the effect of the prior strain-hardening on low cycle fatigue life of 304L stainless steel (SS) exposed to the PWR primary water. A plate of 304LSS was strain hardened by cold rolling or tension prior to fatigue testing. The tests were performed under axial strain-controlled at 300 °C in primary water including B/Li and dissolved hydrogen, and in air. The effect on environmental fatigue life was investigated through a comparison of the Fen in experiments and in regulations, and also the effect on the fatigue limit defined at 106 cycles was discussed.
Prediction of Residual Stress in Multi-Pass Welded Joint Using Idealized Explicit FEM
Authors: Shibahara Masakazu , Itoh Shinsuke , Okada Takashi , Ikushima Kazuki , Nishikawa Satoru 
Published: July 2013

Heavy thick steel plate is used for pipes and also ship structures, and multi-pass welding is usually adopted for the welding. Because of the heavy thickness, residual stress plays an important role, particularly in crack propagation. Implicit Finite Element Method (FEM) is often used as a welding analysis method to examine the residual stress of the welded plate, but it is not easily applied to multi-pass welding problems with tens of thousands of degrees of freedom, because of the huge computational time and memory consumption. Alternatively, it is possible to simulate the residual stress in shorter time with lower memory consumption by using Idealized Explicit Finite Element Method developed by the authors. Moreover, the computational time can be shortened by using Idealized Explicit FEM using a Graphics Processing Unit (GPU). In this research, Idealized Explicit FEM parallelized using a GPU is applied to the analysis of the residual stresses of the multi-pass welding joint of a pipe structure made of heavy thick steel plate.
As the result, the residual stress simulated by the Idealized Explicit FEM corresponds to the measured residual stress. Furthermore, it is found that the grouping method may affect to the residual stress distribution.
Elastic-Plastic Fatigue Evaluation of a Heavy Wall Nozzle Subject to Rapid Thermal Transients
Authors: Dewees David J. , Cooch S. Michael 
Published: July 2013

This paper presents a case study highlighting the use of the elastic-plastic fatigue methods in ASME Section VIII, Division 2 in the design fatigue evaluation of a heavy wall nozzle. The nozzle is expected to undergo a variety of thermal cycles during its design life, some of which include a rapid heatup or cooldown. The elastic fatigue approach is used for the initial evaluation; however, the thermal stresses induced by the rapid transients result in the application of a significant fatigue penalty factor (Ke,k).
An elastic-plastic stress analysis is therefore used to provide a more appropriate evaluation of the fatigue penalty factor for this case. Both the Twice-Yield and cycle-by-cycle methods are used to calculate the fatigue penalty factor, and give very similar results.
Rapid Aggregation of Biofuel-Producing Algae by the Bacterium Bacillus sp. Strain RP1137
Authors: Powell Ryan J. , Hill Russell T. 
Published: July 2013

ABSTRACT

Algal biofuels represent one of the most promising means of sustainably replacing liquid fuels. However, significant challenges remain before alga-based fuels become competitive with fossil fuels. One of the largest challenges is the ability to harvest the algae in an economical and low-energy manner. In this article, we describe the isolation of a bacterial strain,
Bacillus
sp. strain RP1137, which can rapidly aggregate several algae that are candidates for biofuel production, including a
Nannochloropsis
sp. This bacterium aggregates algae in a pH-dependent and reversible manner and retains its aggregation ability after paraformaldehyde fixation, opening the possibility for reuse of the cells. The optimal ratio of bacteria to algae is described, as is the robustness of aggregation at different salinities and temperatures. Aggregation is dependent on the presence of calcium or magnesium ions. The efficiency of aggregation of
Nannochloropsis oceanica
IMET1 is between 70 and 95% and is comparable to that obtained by other means of harvest; however, the rate of harvest is fast, with aggregates forming in 30 s.
Distinct Amino Acids of Histone H3 Control Secondary Metabolism in Aspergillus nidulans
Authors: Nützmann Hans-Wilhelm , Fischer Juliane , Scherlach Kirstin , Hertweck Christian , Brakhage Axel A. 
Published: July 2013

ABSTRACT

Chromatin remodelling events play an important role in the secondary metabolism of filamentous fungi. Previously, we showed that a bacterium,
Streptomyces rapamycinicus
, is able to reprogram the histone-modifying Spt-Ada-Gcn5-acetyltransferase/ADA (SAGA/ADA) complex of the model fungus
Aspergillus nidulans
. Consequently, the histone H3 amino acids lysine 9 and lysine 14 at distinct secondary metabolism genes were specifically acetylated during the bacterial fungal interaction, which, furthermore, was associated with the activation of the otherwise silent orsellinic acid gene cluster. To investigate the importance of the histone modifications for distinct gene expression profiles in fungal secondary metabolism, we exchanged several amino acids of histone H3 of
A. nidulans
. These amino acids included lysine residues 9, 14, 18, and 23 as well as serine 10 and threonine 11. Lysine residues were replaced by arginine or glutamine residues, and serine/threonine residues were replaced by alanine. All generated mutant strains were viable, allowing direct analysis of the consequences of missing posttranslational histone modifications. In the mutant strains, major changes in the expression patterns at both the transcriptional and metabolite levels of the penicillin, sterigmatocystin, and orsellinic acid biosynthesis gene clusters were detected. These effects were due mainly to the substitution of the acetylatable lysine 14 of histone H3 and were enhanced in a lysine 14/lysine 9 double mutant of histone H3. Taken together, our findings show a causal linkage between the acetylation of lysine residue 14 of histone H3 and the transcription and product formation of secondary metabolite gene clusters.
Conservation and Distribution of the Benzalkonium Chloride Resistance Cassette
bcrABC
in Listeria monocytogenes
Authors: Dutta Vikrant , Elhanafi Driss , Kathariou Sophia 
Published: July 2013

ABSTRACT

Analysis of a panel of 116
Listeria monocytogenes
strains of diverse serotypes and sources (clinical, environment of food processing plants, and food) revealed that all but one of the 71 benzalkonium chloride-resistant (BC
r
) isolates harbored
bcrABC
, previously identified on a large plasmid (pLM80) of the 1998-1999 hot dog outbreak strain H7858. In contrast,
bcrABC
was not detected among BC-susceptible (BC
s
) isolates. The
bcrABC
sequences were highly conserved among strains of different serotypes, but variability was noted in sequences flanking
bcrABC
. The majority of the BC
r
isolates had either the pLM80-type of organization of the
bcrABC
region or appeared to harbor
bcrABC
on the chromosome, adjacent to novel sequences. Transcription of
bcrABC
was induced by BC (10 μg/ml) in strains of different serotypes and diverse
bcrABC
region organization. These findings reveal widespread dissemination of
bcrABC
across BC
r
L. monocytogenes
strains regardless of serotype and source, while also suggesting possible mechanisms of
bcrABC
dissemination across
L. monocytogenes
genomes.
EXPLORING THE LINK BETWEEN KNOWLEDGE SHARING ENABLERS, INNOVATION CAPABILITY AND INNOVATION PERFORMANCE
Authors: YEŞIL SALIH , BÜYÜKBEŞE TUBA , KOSKA ALAEDDIN 
Published: July 2013

The intense global competition, rapid technological changes, and higher consumer demands along with increasing uncertainty and risk; all threaten the life of the companies and force them to be more creative and innovative. Thus, business world needs innovative ideas more than ever. Hence, companies struggle to increase their innovative capacities in order to be more competitive. At the same time, performing innovation is not an easy task, it is a process that requires tremendous effort and changes in several parts of business. The number of studies on innovation has increased. Different aspects of innovation from theoretical and practical points of views have been studied so far. This study aims to investigate the effect of knowledge sharing enablers on innovation capability along with the relationship between innovation capability and innovation performance. The findings from the research revealed that some of the components of knowledge sharing enablers have positive effect on the innovation capability, while others have not. Also, remarkable findings on significant positive affect of innovation capability on innovation performance were obtained.
Late Eocene Glaciofluvial to Glaciomarine transition in the Lambert Graben: constraints from lithofacies and mineralogy of ODP Site 1166 sediments, Prydz Bay, Antarctica
Authors: Strand K. , Köykkä J. , Lamminen J. 
Published: July 2013

Abstract

The transition from a glaciofluvial to a glacial sedimentary environment contains critical information for evaluating the onset of glaciation and early glacial dynamics in Antarctica. This study presents investigations of a sediment core from Ocean Drilling Program Leg 188, Site 1166, on the continental shelf in Prydz Bay, in order to provide evidence for the first occurrence of late Eocene glaciers in the Lambert Graben, East Antarctica. The Lambert Graben is a large fault-bounded structure, at least 700 km long and 100 km wide, and presently hosts the Lambert Glacier–Amery Ice Shelf system. The core consists of middle Eocene glacially influenced alluvial plain sediments,
c
. 110 m in total thickness that are overlain by a
c
. 20 m-thick early Oligocene glaciomarine succession. The upper contact is a major unconformity. Grain-surface microtextures, such as fractured plates and a relatively high content of ilmenite in alluvial outwash-plain sediments, indicate mixed northern and southern Prince Charles Mountains provenance and initiation of glaciers as early as middle Eocene time. Distribution of the major heavy minerals indicates a change to garnet-rich granulite terrain in sediment-supply during later ice-sheet evolution, when a lack of detritus from the southern Prince Charles Mountains becomes apparent. Glacier advance was no longer restricted to the Lambert Graben and the drainage area became wider. Good preservation of these low-stand glaciofluvial outwash-plain deposits was related to regional subsidence that progressed to a marine transgression and glaciomarine deposition when ice was able to advance to the continental shelf edge.
Network Analysis Identifies an HSP90-Central Hub Susceptible in Ovarian Cancer
Authors: Liu Hanqing , Xiao Fang , Serebriiskii Ilya G. , O'Brien Shane W. , Maglaty Marisa A. , Astsaturov Igor , Litwin Samuel , Martin Lainie P. , Proia David A. , Golemis Erica A. , Connolly Denise C. 
Published: July 2013

Abstract
Purpose: Epithelial ovarian cancer (EOC) is usually detected at an advanced stage and is frequently lethal. Although many patients respond to initial surgery and standard chemotherapy consisting of a platinum-based agent and a taxane, most experience recurrence and eventually treatment-resistant disease. Although there have been numerous efforts to apply protein-targeted agents in EOC, these studies have so far documented little efficacy. Our goal was to identify broadly susceptible signaling proteins or pathways in EOC.
Experimental Design: As a new approach, we conducted data-mining meta-analyses integrating results from multiple siRNA screens to identify gene targets that showed significant inhibition of cell growth. On the basis of this meta-analysis, we established that many genes with such activity were clients of the protein chaperone HSP90. We therefore assessed ganetespib, a clinically promising second-generation small-molecule HSP90 inhibitor, for activity against EOC, both as a single agent and in combination with cytotoxic and targeted therapeutic agents.
Results: Ganetespib significantly reduced cell growth, induced cell-cycle arrest and apoptosis in vitro, inhibited growth of orthotopic xenografts and spontaneous ovarian tumors in transgenic mice in vivo, and inhibited expression and activation of numerous proteins linked to EOC progression. Importantly, paclitaxel significantly potentiated ganetespib activity in cultured cells and tumors. Moreover, combined treatment of cells with ganetespib and siRNAs or small molecules inhibiting genes identified in the meta-analysis in several cases resulted in enhanced activity.
Conclusion: These results strongly support investigation of ganetespib, a single-targeted agent with effects on numerous proteins and pathways, in augmenting standard EOC therapies. Clin Cancer Res; 19(18); 5053–67. ©2013 AACR.