bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of orphan nuclear receptor NR4A2 in gastric cancer cells confers chemoresistance and predicts an unfavorable postoperative survival of gastric cancer patients with chemotherapy
Authors: Han Yifang , Cai Hui , Ma Liye , Ding Yibo , Tan Xiaojie , Chang Wenjun , Guan Wei , Liu Yan , Shen Qiuxia , Yu Yongwei , Zhang Hongwei , Cao Guangwen 
Published: July 2013

BACKGROUNDNR4A2, an orphan nuclear receptor essential in the generation of dopaminergic neurons, has been recently linked to inflammation and cancer. This study sought to identify the role of NR4A2 on chemoresistance and postoperative prognosis of gastric cancer (GC).METHODSNR4A2 was transfected into GC cells to investigate its effects on chemoresistance to 5‐fluorouracil and the tumorigenicity in nude mice. This study also investigated prostaglandin E2 (PGE2)‐induced NR4A2 expression and its effect on chemoresistance. Surgical specimens from patients with stage I through III GC were examined immunohistochemically for NR4A2 expression. Median follow‐up time was 76 months for 245 patients.RESULTSEctopic expression of NR4A2 significantly increased the chemoresistance and attenuated 5‐fluorouracil–induced apoptosis. Transient treatment of GC cells with PGE2 significantly upregulated NR4A2 expression via the protein kinase A pathway and increased the chemoresistance. Ectopic expression of NR4A2 significantly increased the tumorigenicity. In clinical samples, NR4A2 was preferentially expressed in lymphocytes and epithelial cytoplasm in adjacent mucosa. High expression of NR4A2 (immunoreactive score ≥ 3) in cancer cells significantly predicted an unfavorable postoperative disease‐specific survival of patients with stage I to III GC (P = .011), especially for those who received 5‐fluorouracil–based chemotherapy (P = .016). This effect was not found in those without the chemotherapy. In multivariate Cox analyses, age, TNM (tumor/node/metastasis) stage, and high NR4A2 expression significantly predicted an unfavorable postoperative survival.CONCLUSIONSHigh NR4A2 expression in GC cells confers chemoresistance, attenuates 5‐fluorouracil–induced apoptosis, and predicts an unfavorable survival, especially for those who received chemotherapy. NR4A2 might serve as a prognostic and predictive factor and therapeutic target for patients with GC. Cancer 2013;119:3436–3445.. © 2013 American Cancer Society.
Voltage‐gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin‐induced peripheral neurotoxicity: Results from a prospective multicenter study
Authors: Argyriou Andreas A. , Cavaletti Guido , Antonacopoulou Anna , Genazzani Armando A. , Briani Chiara , Bruna Jordi , Terrazzino Salvatore , Velasco Roser , Alberti Paola , Campagnolo Marta , Lonardi Sara , Cortinovis Diego , Cazzaniga Marina , Santos Cristina , Psaromyalou Aikaterini , Angelopoulou Aikaterini , Kalofonos Haralabos P. 
Published: July 2013

BACKGROUNDThe current prospective, multicenter study sought to identify single nucleotide polymorphisms of voltage‐gated sodium channels (SCNAs) genes that might confer susceptibility to an increased incidence and severity of oxaliplatin‐induced peripheral neuropathy (OXAIPN) in patients treated with either leucovorin, 5‐fluorouracil, and oxaliplatin (FOLFOX) or oxaliplatin plus capecitabine (XELOX) for colorectal cancer (CRC).METHODSA total of 200 patients with CRC were genotyped with real‐time polymerase chain reaction using locked nucleic acid hydrolysis probes or allele‐specific primers. All patients had received oxaliplatin‐based chemotherapy, either in the adjuvant or metastatic setting. The incidence and severity of cumulative OXAIPN was graded using the clinical version of the Total Neuropathy Score and the neurosensory National Cancer Institute Common Toxicity Criteria (version 3.0). The incidence of acute OXAIPN was assessed using a descriptive questionnaire (yes/no response format) at each clinical evaluation. Acute OXAIPN was present in 169 of 200 patients (84.5%), whereas after treatment discontinuation, the cumulative/chronic form of neurotoxicity occurred in 145 of 200 patients (72.5%).RESULTSIn the logistic regression analysis adjusted for confounding factors, the overdominant model (CT vs CC + TT) of 2 single nucleotide polymorphisms (ie, SCN4A‐rs2302237 and SCN10A‐rs1263292) emerged as being significantly associated with an increased incidence of acute OXAIPN (rs2302237: odds ratio of 2.62 [95% confidence interval (95% CI), 1.15‐6.00]; P = .019; and rs12632942: OR of 0.39 [95% CI, 0.17‐0.88]; P = .023). However, only SCN4A‐rs2302237 emerged as also being predictive of the clinical severity of acute OXAIPN (OR, 2.50 [95% CI, 1.35‐4.63]; P = .0029) and the occurrence of cumulative/chronic OXAIPN (OR, 2.47 [95% CI, 1.04‐5.85]; P = .037).CONCLUSIONSThe results of the current study provide evidence to support a causal relationship between SCNA polymorphisms and OXAIPN. However, further studies from independent groups are warranted to confirm these results. Cancer 2013;119:3570–3577.. © 2013 American Cancer Society.
Molecular profiling of the developing avian telencephalon: Regional timing and brain subdivision continuities
Authors: Chen Chun‐Chun , Winkler Candace M. , Pfenning Andreas R. , Jarvis Erich D. 
Published: July 2013

ABSTRACTIn our companion study (Jarvis et al. [2013] J Comp Neurol. doi: 10.1002/cne.23404) we used quantitative brain molecular profiling to discover that distinct subdivisions in the avian pallium above and below the ventricle and the associated mesopallium lamina have similar molecular profiles, leading to a hypothesis that they may form as continuous subdivisions around the lateral ventricle. To explore this hypothesis, here we profiled the expression of 16 genes at eight developmental stages. The genes included those that define brain subdivisions in the adult and some that are also involved in brain development. We found that phyletic hierarchical cluster and linear regression network analyses of gene expression profiles implicated single and mixed ancestry of these brain regions at early embryonic stages. Most gene expression–defined pallial subdivisions began as one ventral or dorsal domain that later formed specific folds around the lateral ventricle. Subsequently a clear ventricle boundary formed, partitioning them into dorsal and ventral pallial subdivisions surrounding the mesopallium lamina. These subdivisions each included two parts of the mesopallium, the nidopallium and hyperpallium, and the arcopallium and hippocampus, respectively. Each subdivision expression profile had a different temporal order of appearance, similar in timing to the order of analogous cell types of the mammalian cortex. Furthermore, like the mammalian pallium, expression in the ventral pallial subdivisions became distinct during prehatch development, whereas the dorsal portions did so during posthatch development. These findings support the continuum hypothesis of avian brain subdivision development around the ventricle and influence hypotheses on homologies of the avian pallium with other vertebrates. J. Comp. Neurol. 521:3666–3701, 2013. © 2013 Wiley Periodicals, Inc.
CSR for Clients’ Social/Environmental Impacts?
Authors: Thien George Ted Khiong 
Published: July 2013

AbstractFinancial services institutions’(FSIs’) potential influence over their network of commercial clients can arguably be used to influence global sustainability, not only on a whole‐scale basis but also immediate. This paper investigates FSIs’ understanding of the corporate social responsibility (CSR) concept, and their motivations for CSR reporting. A thematic analysis of interview transcripts with decision‐makers from two banks, one insurance institution, and two expert stakeholders uncovers an espoused understanding of CSR that is broad, but the aspect of indirect impacts is not given sufficient priority despite the potential holistic effect on society and the environment. The findings do not bode well for substantive systemic change considering FSIs’ latent potential for influencing economic, social and environmental issues through the indirect impacts of their core business products and services. This paper serves to challenge thinking about CSR and CSR reporting held by reporters from FSIs. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment.
Expression of Kv1.3 potassium channels regulates density of cortical interneurons
Authors: Duque Alvaro , Gazula Valeswara‐Rao , Kaczmarek Leonard K. 
Published: July 2013

ABSTRACTThe Kv1.3 protein is a member of the large family of voltage‐dependent K+ subunits (Kv channels), which assemble to form tetrameric membrane‐spanning channels that provide a selective pore for the conductance of K+ across the cell membrane. Kv1.3 differs from most other Kv channels in that deletion of Kv1.3 gene produces very striking changes in development and structure of the olfactory bulb, where Kv1.3 is expressed at high levels, resulting in a lower threshold for detection of odors, an increased number of synaptic glomeruli and alterations in the levels of a variety of neuronal signaling molecules. Because Kv1.3 is also expressed in the cerebral cortex, we have now examined the effects of deletion of the Kv1.3 gene on the expression of interneuron populations of the cerebral cortex. Using unbiased stereology we found an increase in the number of parvalbumin (PV) cells in whole cerebral cortex of Kv1.3−/− mice relative to that in wild‐type mice, and a decrease in the number of calbindin (CB), calretinin (CR), neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), and somatostatin (SOM) interneurons. These changes are accompanied by a decrease in the cortical volume such that the cell density of PV interneurons is significantly increased and that of SOM neurons is decreased in Kv1.3−/− animals. Our studies suggest that, as in the olfactory bulb, Kv1.3 plays a unique role in neuronal differentiation and/or survival of interneuron populations and that expression of Kv1.3 is required for normal cortical function. © 2013 Wiley Periodicals, Inc. Develop Neurobiol 73:841–855, 2013
High‐throughput SNP‐genotyping analysis of the relationships among Ponto‐Caspian sturgeon species
Authors: Rastorguev Sergey M. , Nedoluzhko Artem V. , Mazur Alexander M. , Gruzdeva Natalia M. , Volkov Alexander A. , Barmintseva Anna E. , Mugue Nikolai S. , Prokhortchouk Egor B. 
Published: July 2013

AbstractLegally certified sturgeon fisheries require population protection and conservation methods, including DNA tests to identify the source of valuable sturgeon roe. However, the available genetic data are insufficient to distinguish between different sturgeon populations, and are even unable to distinguish between some species. We performed high‐throughput single‐nucleotide polymorphism (SNP)‐genotyping analysis on different populations of Russian (Acipenser gueldenstaedtii), Persian (A. persicus), and Siberian (A. baerii) sturgeon species from the Caspian Sea region (Volga and Ural Rivers), the Azov Sea, and two Siberian rivers. We found that Russian sturgeons from the Volga and Ural Rivers were essentially indistinguishable, but they differed from Russian sturgeons in the Azov Sea, and from Persian and Siberian sturgeons. We identified eight SNPs that were sufficient to distinguish these sturgeon populations with 80% confidence, and allowed the development of markers to distinguish sturgeon species. Finally, on the basis of our SNP data, we propose that the A. baerii‐like mitochondrial DNA found in some Russian sturgeons from the Caspian Sea arose via an introgression event during the Pleistocene glaciation.
One‐Pot Synthesis of Mn‐Doped CeO2 Nanospheres for CO Oxidation
Authors: Zhang Xueying , Wei Jingjing , Yang Hongxiao , Liu Xiufang , Liu Wei , Zhang Cong , Yang Yanzhao 
Published: July 2013

AbstractCeria nanoparticles with 4 and 7 atom‐% manganese dopant were synthesized through a template‐free solvothermal method. The structure of the samples was characterized by powder X‐ray diffraction (XRD). Monodispersed nanospheres of average size 130 nm were observed in transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), and field‐emission scanning electron microscopy (FE‐SEM) analyses. Manganese ions were introduced into the system and it is confirmed that the Mn species dissolve within the CeO2 lattice by Raman spectroscopy and X‐ray photoelectron spectroscopy (XPS). Furthermore, the as‐obtained Mn‐doped ceria nanoparticles revealed superior catalytic performance in CO oxidation in contrast with pure CeO2 prepared by the same route.
In Situ Formation of Vilsmeier Reagents Mediated by Oxalyl Chloride: a Tool for the Selective Synthesis of N‐Sulfonylformamidines
Authors: Gazvoda Martin , Kočevar Marijan , Polanc Slovenko 
Published: July 2013

AbstractN‐Sulfonylformamidines were produced from sulfonamides or N‐acylated sulfonamides using Vilsmeier reagent obtained in situ from N,N‐disubstituted formamides and oxalyl chloride. Optically active substrates did not racemize during the process. The efficient and mild cleavage of N‐sulfonylformamidines can be achieved with hydrazine hydrate in ethanol. The entire procedure constitutes a simple method for protecting, and deprotecting, the sulfonamide moiety.
Enantio‐ and Diastereoselective Syntheses of 3‐Hydroxypiperidines through Iridium‐Catalyzed Allylic Substitution
Authors: Hoecker Johannes , Rudolf Georg C. , Bächle Florian , Fleischer Steffen , Lindner Benjamin D. , Helmchen Günter 
Published: July 2013

AbstractStereoselective syntheses of 3‐hydroxypiperidines have been developed. Key intermediates areN‐protected allylamines that are prepared by an enantioselective iridium‐catalyzed allylic amination. A subsequent catch and release procedure that involves an epoxidation and base‐mediated elimination yields δ‐lactams that are suitably functionalized to prepare biologically active 3‐hydroxypiperidines. In addition, applications of this method to the total syntheses of deoxymannojirimycin,D‐erythro‐sphingosine, and chiral building blocks of interest for medicinal chemistry are described.
Hijab, visibility and the performance of identity
Authors: Hopkins Nick , Greenwood Ronni Michelle 
Published: July 2013

AbstractTheories concerning the relationship between social identification and behaviour are increasingly attentive to how group members emphasise or de‐emphasise identity‐related attributes before particular audiences. Most research on this issue is experimental and explores the expression of identity‐related attitudes as a function of participants' beliefs concerning their visibility to different audiences. We extend and complement such research with an analysis of group members' accounts of their identity performances. Specifically, we consider British Muslim women's (n = 22) accounts of wearing hijab (a scarf covering the hair) and how this visible declaration of religious identity is implicated in the performance of their religious, national and gender identities. Our analysis extends social psychological thinking on identity performance in three ways. First, it extends our understandings of the motivations for making an identity visible to others. Second, it sheds light on the complex relationship between the performance of one (e.g. Muslim) identity and the performance of other (e.g. gender/national) identities. Third, it suggests the experience of making an identity visible can facilitate the subsequent performance of that identity. The implications of these points for social identity research on identity performance are discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Less is more: The effect of multiple implementation intentions targeting unhealthy snacking habits
Authors: Verhoeven Aukje A. C. , Adriaanse Marieke A. , de Ridder Denise T. D. , de Vet Emely , Fennis Bob M. 
Published: July 2013

AbstractImplementation intentions have been shown to effectively change counter‐intentional habits. Research has, however, almost solely been concerned with the effectiveness of a single plan. In the present research, we investigated the behavioral and cognitive implications of making multiple implementation intentions targeting unhealthy snacking habits and its underlying processes, linking multiple habitual snacking cues to healthy alternatives. Study 1 revealed that formulating multiple implementation intentions was not effective in decreasing unhealthy snacking, whereas formulating a single plan successfully induced behavior change. By using a lexical decision task in Study 2, it was found that when making a single plan, but not multiple plans, the healthy alternative became cognitively more accessible in response to a critical cue prime than the habitual response. However, when making additional plans in an unrelated domain, the negative effects of making multiple plans were absent. In sum, the current findings suggest that formulating multiple implementation intentions is ineffective when changing unwanted behavior. These reduced effects of multiple implementation intentions do not occur when making the plan but are rather due to interference in the enacting phase of the planning process. Copyright © 2013 John Wiley & Sons, Ltd.
Retribution and forgiveness: The healing effects of punishing for just deserts
Authors: Strelan Peter , van Prooijen Jan‐Willem 
Published: July 2013

AbstractAlthough punishment and forgiveness frequently are considered to be opposites, in the present paper we propose that victims who punish their offender are subsequently more likely to forgive. Notably, punishment means that victims get justice (i.e. just deserts), which facilitates forgiveness. Study 1 reveals that participants were more likely to forgive a friend's negligence after being primed with punishment than after being primed with inability to punish. In Study 2, participants were more forgiving towards a criminal offender if the offender was punished by a judge than if the offender escaped punishment, a finding that was mediated by the just deserts motive. Study 3 was in the context of actual recalled ongoing interpersonal relations and revealed that punishment predicted forgiveness indirectly via just deserts, not via victims' vengeful motivations. It is concluded that punishment facilitates forgiveness because of its capacity to restore a sense of justice. Copyright © 2013 John Wiley & Sons, Ltd.
Leben am Limit
Authors: Stoeck Thorsten , Weinisch Lea 
Published: July 2013

AbstractIn den Nahrungsnetzen der Meere spielen Einzeller eine Schlüsselrolle. �‐kologen sind der Evolution und der Artenvielfalt des Mikrobenplanktons auf der Spur — auf dem Grund der lebensabweisenden sauerstoffarmen Tiefseebecken des Mittelmeeres und im Labor.
COMBINED OPTIMIZATION OF SOYBEAN WATER PRODUCTIVITY AND CROP YIELD BY MULTI‐OBJECTIVE GENETIC ALGORITHM (MOGA)
Authors: Babazadeh Hossein , Tabrizi Mahdi Sarai 
Published: July 2013

ABSTRACTOne of the meta‐heuristic algorithms for multi‐objective optimization under conditions where there are more than one objective in research is the multi‐objective genetic algorithm (MOGA). The goal of this research is combined optimization of water productivity (WP) and crop yield under deficit irrigation management conditions. The data used in this study are the result of an experimental agricultural design conducted in the form of a randomized complete blocks design in three replications and seven water stress treatments at different growth stages in 2010 in Karaj. The results of this research show that in combined optimization under the first scenario conditions, the amounts of soybean optimum crop yield and optimum WP are 3830 kg ha−1 and 0.529 kg m−3 respectively. Also in combined optimization under the second scenario conditions, the amount of optimum crop yield and WP are 3840 kg ha−1 and 1.12 kg m−3 respectively. Copyright © 2013 John Wiley & Sons, Ltd.
A network of interorganellar communications underlies cellular aging
Authors: Leonov Anna , Titorenko Vladimir I. 
Published: July 2013

AbstractOrganelles within a eukaryotic cell respond to age‐related intracellular stresses and environmental factors by altering their functional states to generate, direct and process the flow of interorganellar information that is essential for establishing a pro‐ or antiaging cellular pattern. The scope of this review is to critically analyze recent progress in understanding how various intercompartmental (i.e., organelle–organelle and organelle–cytosol) communications regulate cellular aging in evolutionarily distant eukaryotes. Our analysis suggests a model for an intricate network of intercompartmental communications that underly cellular aging in eukaryotic organisms across phyla. This proposed model posits that the numerous directed, coordinated and regulated organelle–organelle and organelle–cytosol communications integrated into this network define the long‐term viability of a eukaryotic cell and, thus, are critical for regulating cellular aging. © 2013 IUBMB Life, 65(8):665–674, 2013
Influence of Efficacy and Resilience on Problem Solving in the United States, Taiwan, and China
Authors: Li Ming‐hui , Eschenauer Robert , Yang Yan 
Published: July 2013

This study explores factors that influence problem‐solving coping style across cultures. There was no significant difference in applying problem solving across U.S., Taiwanese, and Chinese samples. The effective predictors of problem solving in the U.S. and Chinese samples were self‐efficacy and trait resilience, respectively. In the Taiwanese sample, predictors were self‐efficacy and trait resilience. Trait resilience was found to mediate the effect of self‐efficacy on problem solving in the Taiwanese and Chinese samples. Practical implications are discussed.Este estudio explora factores que influyen en el estilo de afrontamiento a la resolución de problemas aplicado a distintas culturas. No se halló una diferencia significativa en la aplicación de resolución de problemas entre muestras estadounidenses, taiwaneses y chinas. Los predictores efectivos de la resolución de problemas en las muestras estadounidense y china fueron respectivamente la autoeficacia y los rasgos de resiliencia. En la muestra taiwanesa, los predictores fueron las autoeficacia y los rasgos de resiliencia. Se halló que los rasgos de resiliencia mediaron el efecto de la autoeficacia sobre la resolución de problemas en las muestras taiwanesa y china. Se discuten las implicaciones prácticas.