bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vortioxetine’s impact on the autonomic nervous system in depressed children and adolescents: analysis of the heart rate variability
Authors: Krivosova Michaela , Hutka Peter , Ondrejka Igor , Visnovcova Zuzana , Funakova Dana , Hrtanek Igor , Ferencova Nikola , Mlyncekova Zuzana , Kovacova Veronika , Macejova Andrea , Kukucka Tomas , Mokry Juraj , Tonhajzerova Ingrid 
Published: June 2024

AbstractRelationship between depressive disorder and autonomic nervous system has been already discussed. Reduced emotional regulation is supposed to be associated with prefrontal hypofunction and subcortical hyperactivity. The aim of this study was to determine the effect of vortioxetine on heart rate variability (HRV), a parameter of cardiac autonomic regulation, in depressed hospitalized paediatric patients and assess the clinical effectiveness of the drug in this population. We performed repeated polysomnography analyses at admission and after a short treatment in hospital (15.2 days on average) and measured various HRV parameters (RRi, pNN50, RMSSD, LF-HRV, HF-HRV) during wakefulness, N3 and REM sleep stages. Out of 27 study subjects, 67% have improved depression symptoms as well as anxiety and subjective sleep quality after short vortioxetine treatment. We have found a significant decrease in parasympathetic parameters pNN50, RMSSD and HF-HRV during N3 sleep phase, though not exclusively among vortioxetine responders. The anticipated increase in cardiovagal regulation after vortioxetine treatment was not demonstrated in this pilot study, possibly due to the drug’s multimodal mechanism and impact on the nucleus tractus solitarii, particularly its antagonism on 5HT-3 receptors. Application of selective drugs could further explain the effect of vortioxetine on HRV in depressed patients.
Digital replica to unveil the impact of growing conditions on orange postharvest quality
Authors: Onwude Daniel , Cronje Paul , North Jade , Defraeye Thijs 
Published: June 2024

AbstractThe postharvest end-quality of citrus is significantly impacted by pre-harvest factors such as weather, which varies among growing regions. Despite the importance of these factors, the influence of regional weather variations, such as variations in temperature, humidity, wind, vapor pressure deficit (VPD), and solar radiation on postharvest citrus quality, is largely unknown. This study aims to quantify this impact through a physics-driven digital replica of the entire value chain of Valencia oranges, from orchards in South Africa to retail in Europe. Predicted fruit properties data at harvest and hygrothermal sensor data from orchard to retail for different production regions are coupled to a physics-based fruit model to simulate key postharvest fruit quality metrics. These metrics include mass loss, chilling injury, fruit quality index (FQI), remaining shelf life (RSL), total soluble solids (TSS), and titratable acidity (TA). Our digital fruit model reveals that regional weather variability significantly affects fruit quality evolution when comparing data from Nelspruit, Letsitele, and Sunday’s River Valley (SRV). The impact of weather variations is most pronounced in the temperate oceanic climate of SRV compared to the hotter climates of Letsitele and Nelspruit. Our findings indicate that differences in weather conditions between these growing regions impact postharvest mass loss, FQI, RSL, TSS, and TA of Valencia oranges at retail. The impact is up to 10% variation in mass loss and RSL, 4% in TSS, and 1% in TA among oranges grown in different regions. We show that temperature and humidity variations in the postharvest local transport of oranges between different regions largely increase mass loss by up to twofold, FQI by up to ~ 12%, and RSL by up to ~ 15% at retail. Our research also shows that weather temperature is the most important metric during fruit growth affecting various aspects of postharvest orange quality. This study offers valuable insights into the impact of regional weather variations on the quality of oranges available to consumers. These findings could help the citrus industry enhance growing practices, postharvest logistics, retail marketing, and cold chain strategies, thereby improving product quality and consumer satisfaction.
Mechanical response of long-span CFST arch bridges based on the hydration heat temperature effect
Authors: Wu Yuexing , Wen Qiang , Dai Meihong , Wang Xinzhong , Li Xingxin , Tan Xianliang 
Published: June 2024

AbstractAs the span of concrete-filled steel tube (CFST) arch bridges increases, the hydration heat temperature effect of concrete inside steel tube becomes more severe, which increases the safety risk during the construction process. Therefore, a numerical simulation of the mechanical response of a long-span CFST arch bridge under the influence of hydration heat was carried out. First, based on the hydration heat conduction theory, a finite element model of the transient temperature field of a CFST arch rib was established. The temperature distribution of the CFST arch rib and its variation with time were revealed, and an approximate formula for the distribution of the hydration heat temperature along the radial direction of the CFST was provided. Subsequently, the variation law of the thermal stress of a CFST during hydration heat release was investigated. Finally, based on the principle of temperature equivalence, a finite element model of the overall CFST arch rib was established to examine the effect of hydration heat on the deformation of the arch rib. The results reveal that the hydration heat temperature field of the CFST arch rib exhibits nonlinear and axisymmetric characteristics. The maximum temperature of the section and the maximum temperature difference can reach 73.5 °C and 33.2 °C, respectively. Because of the influence of the hydration heat, there is a significant stress gradient in the cross section of the arch rib. A maximum radial stress of 2.08 MPa is attained, indicating a risk of concrete cracking. Additionally, the displacement along the transverse and vertical directions of the chord tube exhibits an initial increase, followed by a decrease over time. The maximum transverse displacement of the chord tube reaches 70.6 mm, while the vertical displacement reaches 117.8 mm.
Control of cascading failures using protective measures
Authors: Fazli Davood , Khanjanianpak Mozhgan , Azimi-Tafreshi Nahid 
Published: June 2024

AbstractCascading failures, triggered by a local perturbation, can be catastrophic and cause irreparable damages in a wide area. Hence, blocking the devastating cascades is an important issue in real world networks. One of the ways to control the cascade is to use protective me‌asures, so that the agents decide to be protected against failure. Here, we consider a coevolution of the linear threshold mo‌del for the spread of cascading failures and a decision-making game based on the perceived risk of failure. Protected agents are less vulnerable to failure and in return the size of the cascade affects the agent’s decision to get insured. We find at what range of protection efficiency and cost of failure, the global cascades stop. Also we observe that in some range of protection efficiency, a bistable region emerges for the size of cascade and the prevalence of protected agents. Moreover, we show how savings or the ability of agents to repair can prevent cascades from occurring.
Synthesis of borocarbonitride nanosheets from biomass for enhanced charge separation and hydrogen production
Authors: Luo Zhishan , Chen Jinhao , Fang Yuanmeng , Xie Liyan , Liu Qing , Huang Jianhui , Liu Minghua 
Published: June 2024

AbstractBorocarbonitride (BCN) materials have shown significant potential as photocatalysts for hydrogen production. However, traditional bulk BCN exhibits only moderate photocatalytic activity. In this study, we introduce an environmentally conscious and sustainable strategy utilizing biomass-derived carbon sources to synthesize BCN nanosheets. The hydrogen evolution efficiency of BCN-A nanosheets (110 μmol h−1 g−1) exceeds that of bulk BCN photocatalysts (12 μmol h−1 g−1) by 9.1 times, mainly due to the increased surface area (205 m2g−1) and the presence of numerous active sites with enhanced charge separation capabilities. Notably, the biomass-derived BCN nanosheets offer key advantages such as sustainability, cost-effectiveness, and reduced carbon footprint during hydrogen production. These findings highlight the potential of biomass-based BCN nanomaterials to facilitate a greener and more efficient route to hydrogen energy, contributing to the global transition towards renewable energy solutions.
Characterization of a Lactobacillus gasseri strain as a probiotic for female vaginitis
Authors: Zhang Jingyan , Li Kailing , Cao Tishuang , Duan Zhi 
Published: June 2024

AbstractVaginitis, a prevalent gynecological condition in women, is mainly caused by an imbalance in the vaginal micro-ecology. The two most common types of vaginitis are vaginal bacteriosis and vulvovaginal candidiasis, triggered by the virulent Gardnerella vaginalis and Candida albicans, respectively. In this study, a strain capable of inhibiting G. vaginalis and C. albicans was screened from vaginal secretions and identified as Lactobacillus gasseri based on 16S rRNA sequences. The strain, named L. gasseri VHProbi E09, could inhibit the growth of G. vaginalis and C. albicans under co-culture conditions by 99.07% ± 0.26% and 99.95% ± 0.01%, respectively. In addition, it could significantly inhibit the adhesion of these pathogens to vaginal epithelial cells. The strain further showed the ability to inhibit the enteropathogenic bacteria Escherichia coli and Salmonella enteritidis, to tolerate artificial gastric and intestinal fluids and to adhere to intestinal Caco-2 cells. These results suggest that L. gasseri VHProbi E09 holds promise for clinical trials and animal studies whether administered orally or directly into the vagina. Whole-genome analysis also revealed a genome consisting of 1752 genes for L. gasseri VHProbi E09, with subsequent analyses identifying seven genes related to adhesion and three genes related to bacteriocins. These adhesion- and bacteriocin-related genes provide a theoretical basis for understanding the mechanism of bacterial inhibition of the strain. The research conducted in this study suggests that L. gasseri VHProbi E09 may be considered as a potential probiotic, and further research can delve deeper into its efficacy as an agent which can restore a healthy vaginal ecosystem.
Prediction of Robotic Anastomosis Competency Evaluation (RACE) metrics during vesico-urethral anastomosis using electroencephalography, eye-tracking, and machine learning
Authors: Shafiei Somayeh B. , Shadpour Saeed , Mohler James L. , Rashidi Parisa , Toussi Mehdi Seilanian , Liu Qian , Shafqat Ambreen , Gutierrez Camille 
Published: June 2024

AbstractResidents learn the vesico-urethral anastomosis (VUA), a key step in robot-assisted radical prostatectomy (RARP), early in their training. VUA assessment and training significantly impact patient outcomes and have high educational value. This study aimed to develop objective prediction models for the Robotic Anastomosis Competency Evaluation (RACE) metrics using electroencephalogram (EEG) and eye-tracking data. Data were recorded from 23 participants performing robot-assisted VUA (henceforth ‘anastomosis’) on plastic models and animal tissue using the da Vinci surgical robot. EEG and eye-tracking features were extracted, and participants’ anastomosis subtask performance was assessed by three raters using the RACE tool and operative videos. Random forest regression (RFR) and gradient boosting regression (GBR) models were developed to predict RACE scores using extracted features, while linear mixed models (LMM) identified associations between features and RACE scores. Overall performance scores significantly differed among inexperienced, competent, and experienced skill levels (P value < 0.0001). For plastic anastomoses, R2 values for predicting unseen test scores were: needle positioning (0.79), needle entry (0.74), needle driving and tissue trauma (0.80), suture placement (0.75), and tissue approximation (0.70). For tissue anastomoses, the values were 0.62, 0.76, 0.65, 0.68, and 0.62, respectively. The models could enhance RARP anastomosis training by offering objective performance feedback to trainees.
Neurological Impact of Slower Rewarming during Bypass Surgery in Infants
Authors: Muehlschlegel Geeske , Kubicki Rouven , Jacobs-LeVan Julia , Kroll Johannes , Klemm Rolf , Humburger Frank , Stiller Brigitte , Fleck Thilo 
Published: June 2024

Abstract
Background Hypothermia is a neuroprotective strategy during cardiopulmonary bypass. Rewarming entailing a rapid rise in cerebral metabolism might lead to secondary neurological sequelae. In this pilot study, we aimed to validate the hypothesis that a slower rewarming rate would lower the risk of cerebral hypoxia and seizures in infants.
Methods This is a prospective, clinical, single-center study. Infants undergoing cardiac surgery in hypothermia were rewarmed either according to the standard (+1°C in < 5 minutes) or a slow (+1°C in > 5–8 minutes) rewarming strategy. We monitored electrocortical activity via amplitude-integrated electroencephalography (aEEG) and cerebral oxygenation by near-infrared spectroscopy during and after surgery.
Results Fifteen children in the standard rewarming group (age: 13 days [5–251]) were cooled down to 26.6°C (17.2–29.8) and compared with 17 children in the slow-rewarming group (age: 9 days [4–365]) with a minimal temperature of 25.7°C (20.1–31.4). All neonates in both groups (n = 19) exhibited suppressed patterns compared with 28% of the infants > 28 days (p < 0.05). During rewarming, only 26% of the children in the slow-rewarming group revealed suppressed aEEG traces (vs. 41%; p = 0.28). Cerebral oxygenation increased by a median of 3.5% in the slow-rewarming group versus 1.5% in the standard group (p = 0.9). Our slow-rewarming group revealed no aEEG evidence of any postoperative seizures (0 vs. 20%).
Conclusion These results might indicate that a slower rewarming rate after hypothermia causes less suppression of electrocortical activity and higher cerebral oxygenation during rewarming, which may imply a reduced risk of postoperative seizures.
Peripherally Inserted Central Venous Catheter (PICC) Line Use for Conjoined Twins: Single-Center Experience
Authors: Elzahrani Mohamed , Zahrani Yousof Al , Alqarni Alwaleed , Alothri Meshal , Moaiqel Mohammed Al , Alotaibi Mohammed , Alzahrani Amin , Almulhim Abdulaziz 
Published: June 2024

Abstract
Purpose This article assesses the feasibility, safety, and efficacy of peripherally inserted central catheters (PICCs) in conjoined twins.
Material and Methods A retrospective chart review of all consecutive conjoined twins who had PICC placement at a tertiary center. Seventeen conjoined twins (12 females; 71%) had 25 PICC insertions. The average age of patients at PICC insertion was 15.9 ± 19.3 months. The most common type of twin was thoraco-omphalopagus (5 patients; 29%). The most common access was the brachial vein (N = 10, 40%). Thirteen procedures (52%) were performed before separation.
Results Seven long-term minor complications were identified (28%). The most common complication was malpositioning (8%). Average dwell time was 122 days while the average fluoroscopy time was 2 minutes and 3 seconds.
Conclusion Image-guided PICC placement in conjoined twins is safe and feasible. It provides excellent durable vascular access.
Normative Data of Carpal Bone Measurements in the Sample Adult Indian Population
Authors: Bhat Anil K. , Pandey Arvind Kumar , G. Mithun Pai , MS Raghavendra , M. Chethan Kumar , Singh Shaurya Vikram 
Published: June 2024

Abstract
Introduction Radiography is the most often accessible and affordable imaging modality. Accurate assessments of wrist X-rays can aid in the diagnosis and prognostic evaluation of various wrist problems. This study aims to identify normal radiographic anthropometry reference values and variations of carpal bones and joints by gender and age in sample Indian population, with the potential to be clinically applicable.
Materials and Methods Two investigators conducted a prospective analysis of normal wrist radiographs in a single center. Radiology Information Systems and Picture Archiving and Communication Systems were used to collect standard digitized normal X-rays without significant osseous pathology over a year. We conducted measurements of length, angles, and indices in a standard posteroanterior and lateral wrist X-rays in order to establish the standard dimensions and variances based on age and gender.
Results A total of 18 measurements which included eight linear measurements, eight angles, and two ratios were documented. A total of 500 X-rays of 250 males and 250 females with 125 of each in two age groups of 20 and 40 years and 41 and 60 years were evaluated.
Conclusion This work is a comprehensive database of the Indian population measuring parameters in normal wrist radiographs of posteroanterior and lateral views. The results of our study indicate that men and younger individuals had a significantly higher carpal height ratio. The width of distal radial ulnar joint space was significantly lesser in older subjects. Additionally, males showed a significantly higher lunate uncovered ratio and radial height. When compared to the literature, the study revealed a significant positive ulnar variance in elderly people and women. However, we noted an overall increase in the percentage of positive ulnar variance individuals in our study. We also recorded a marginal increase in radial inclination with no variations across gender and age.
Does Timing of Coronary Artery Bypass Grafting after ST-Elevation Myocardial Infarction Impact Early- and Long-Term Outcomes?
Authors: Kang Jagdip , Marin-Cuartas Mateo , Auerswald Luise , Deo Salil V. , Borger Michael , Davierwala Piroze , Verevkin Alexander 
Published: June 2024

Abstract
Background The optimal timing of surgical revascularization after ST-elevation myocardial infarction (STEMI) is controversial, with some suggesting higher mortality rates in patients undergoing early surgery. The aim of the study is to determine the effect of the timing of surgical revascularization on 30-day mortality and long-term outcomes in these patients.
Methods Retrospective single-center analysis of patients with STEMI undergoing coronary artery bypass grafting (CABG) between January 2008 and December 2019 at our institution. The cohort was split into three groups based on time from symptom onset until surgical revascularization (Group 1: <12 hours, Group 2: 12–72 hours, Group 3: >72 hours). Statistical analyses were performed with and without patients in cardiogenic shock. Primary outcomes were 30-day mortality and 10-year survival.
Results During the study period, 437 consecutive patients underwent surgical revascularization in the setting of STEMI. The mean age was 67.0 years, 96 (22.0%) patients were female, and 281 (64.3%) patients underwent off-pump CABG. The overall 30-day mortality including patients with cardiogenic shock was 12.8%. The 30-day mortality was 16.1, 13.9, and 9.3% in Groups 1, 2, and 3 (p = 0.31), whereas 10-year survival was 48.5, 57.3, and 54.9% (log-rank: p = 0.40). After exclusion of patients in cardiogenic shock, there was no difference between the three groups in 30-day and 10-year mortality. Timing of surgery had no influence on early- and long-term survival.
Conclusion In patients with STEMI, early surgical revascularization achieved similar early- and long-term survival rates compared with a delayed surgical revascularization strategy. Hence, when indicated, an early CABG strategy has no disadvantages in comparison to a delayed strategy.
Normative Values for Thumb Length in Central Indian Adult Population
Authors: Agarwal Pawan , Thatte M. R. , Saraf Mansi , Bobba Rajesh , Sharma Dhananjaya , Dhakar Jagmoah Singh 
Published: June 2024

Abstract
Introduction This article aims to establish the relative thumb length in comparison to the index finger in central Indian adults.
Materials and Methods Five hundred normal adult hands (1,000 thumbs), 316 men and 184 women, mean age 30 years, were included in the study. The relative length of the thumb was measured using the length of the proximal phalanx of the index finger (thumb–proximal phalanx index) and the distance between the proximal digital crease and proximal interphalangeal crease of the index finger (thumb–digital crease index).
Results The tip of a normal adducted thumb extends to 69% of the length of the proximal phalanx of the index finger and 38% of the distance between the two proximal creases of the index finger. The tip of a normal adducted thumb extends to 68% for male and 69% for female of the length of the proximal phalanx of the index finger. For the dominant hand the tip of a normal adducted thumb extends to 68%, while for nondominant hand it reaches 71% of the length of the proximal phalanx of the index finger. The difference between the laterality, gender, and hand dominance was not statistically significant.
Conclusion The tip of a normal adducted thumb extends to 69% of the length of the proximal phalanx of the index finger and 38% of the distance between the two proximal creases of the index finger. Relative normal thumb length is independent of gender, laterality, or hand dominance.
Brand commitment as predecessor to the factors of continuance intention
Authors: Amoroso Donald L. , Ackaradejruangsri Pajaree 
Published: June 2024

AbstractJapanese consumers have always been placed as one of the most highly loyal consumers in the world who are committed to purchasing certain brands for products in many different industries, such as automobiles, luxury goods, and electronics, to name a few. However in recent years, there is evidence to suggest that brand commitment in Japan is decreasing. In this study, we collected data from consumers in 2018 and again in 2023 using the same instrument to ascertain the change in brand commitment as a predecessor of consumer satisfaction, loyalty, and habit and ultimately their impacts on continuance behavior in using mobile wallet applications. We did not find the relationship between satisfaction and continuance intention to be significant in the 2023 model, unlike earlier. The results of this 5-year study comparison revealed that brand commitment was found to be a predecessor construct to both Japanese consumer satisfaction and habit across the years. It was also found that loyalty mediated the relationship between both habit and consumer satisfaction with continuance intention of mobile wallet applications usage. In summary, we found that brand commitment was significant in its relationship to satisfaction, loyalty and habit both in the 2018 and 2023 studies. This indicates a sustained and strong level of brand commitment in the mobile applications context by Japanese consumers. With this research, the knowledge on the well-known constructs of brand commitment, consumer satisfaction, loyalty, habit, and continuance intention have been extended in the area of mobile wallet applications. The findings provide up-to-date insights that have high relevance and important managerial implications in the international marketing research context beyond Japan.