bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of advanced cutaneous T‐cell lymphomas with non‐pegylated liposomal doxorubicin – Consensus of the lymphoma group of the Working Group Dermatologic Oncology
Authors: Assaf Chalid , Becker Jürgen C. , Beyer Marc , Cozzio Antonio , Dippel Edgar , Klemke Claus‐Detlev , Kurschat Peter , Weichenthal Michael , Stadler Rudolf 
Published: January 2013

SummaryBackground:Systemic treatment with pegylated liposomal doxorubicin is an established second‐line treatment of advanced cutaneous T‐cell lymphoma. Pegylated liposomal doxorubicin (PLD) is currently unavailable, therefore, clinical studies investigating the efficacy of non‐pegylated liposomal formula (NPLD) have been analyzed.Methods:Since clinical trials comparing PLD and NPLD in CTCL do not exist, the clinical use of NPLD including safety and efficiency profile in other types of non‐Hodgkin lymphoma were analyzed.Results:Clinical trials show a comparable efficacy of NPLD and PLD in non‐Hodgkin lymphoma. The dosage of NPLD used in the treatment of systemic lymphoma within polychemotherapy regimens was 50 mg/m2 every three weeks. Overall response was 75–95%, including a complete remission rate of 65–80% and 2‐ and 3‐year overall survival rates of 55–75%. These data indicate that the non‐pegylated formula of doxorubicin has a similar antitumor effect as the pegylated one but shows reduced cardiotoxicity. The palmoplantar erythrodysesthesia frequently observed in PLD has not been observed with the use of the NPLD.Conclusions:The clinical use of NPLD in the treatment of CTCL is reasonable. In analogy to the clinical trials of NPLD in non‐Hodgkin lymphoma a dosage of 50 mg/m2 every three weeks is recommended for the treatment of CTCL.
Greater potency of darbepoetin‐α than erythropoietin in suppression of serum hepcidin‐25 and utilization of iron for erythropoiesis in hemodialysis patients
Authors: Shoji Shigeichi , Inaba Masaaki , Tomosugi Naohisa , Okuno Senji , Ichii Mitsuru , Yamakawa Tomoyuki , Kurihara Satoshi 
Published: January 2013

AbstractBackgroundThe potency of darbepoetin‐α (DPO‐α) to improve anemia in hemodialysis (HD) patients is greater than that of recombinant human erythropoietin (rHuEPO).Design and methodsTo assess the potency of DPO‐α to mobilize iron from body stores in comparison with rHuEPO in HD patients without apparent inflammation or infection, serum iron, transferrin saturation (TSAT), ferritin, and hepcidin‐25 were measured serially. This study included (i) a long‐term crossover study for 3 yr to compare the effects of the two erythropoiesis‐stimulating agents (ESA) on serum iron, TSAT, and ferritin, and (ii) a short‐term crossover study for 8 wk to examine their effects on serum hepcidin‐25 in HD patients.ResultsThe long‐term crossover study demonstrated that the change of ESA from rHuEPO to DPO‐α significantly decreased serum ferritin while serum iron and TSAT remained unchanged, while DPO‐α as well as rHuEPO maintained hemoglobin level in the target range between 10.0 and 11.0 g/dL. Furthermore, in the short‐term crossover study, area under the percent suppression of serum hepcidin‐25 time curve for the first 7 d during the DPO‐α treatment period was significantly greater than that during the rHuEPO period (348.0 ± 92.4 vs. 178.4 ± 131.5%.day P = 0.030). The greater suppression of hepcidin‐25 by DPO‐α may facilitate iron mobilization, resulting in diminution of body iron stores without any significant effect on serum iron utilizable for erythropoiesis.ConclusionThis study demonstrated that DPO‐α has a greater advantage than rHuEPO in that it facilitates iron mobilization from body stores into bone marrow to induce effective erythropoiesis and thus could protect against possible harmful effects caused by excessive iron stores in the body.
Long‐term molecular remission with lenalidomide treatment of relapsed chronic lymphocytic leukemia
Authors: Spina Francesco , Rezzonico Francesca , Farina Lucia , Corradini Paolo 
Published: January 2013

AbstractLenalidomide is effective against relapsed chronic lymphocytic leukemia (CLL). We report the first case of long‐term molecular remission with continuous lenalidomide treatment in a young patient with CLL relapsed to multiple treatments. Minimal residual disease was assessed by nested polymerase chain reaction on bone marrow samples with patient‐specific primers. A 20‐yr‐old patient with standard‐risk CLL was treated with lenalidomide after multiple relapses and achieved a 4 yr long complete molecular response with minimal toxicities. Published biologic data support that lenalidomide induces an immune‐mediated control of CLL, and our case suggests that long‐term treatment with lenalidomide is effective at a molecular level in patients with relapsed CLL.
The future of soil invertebrate communities in polar regions: different climate change responses in the Arctic and Antarctic?
Authors: Nielsen Uffe N. , Wall Diana H. 
Published: January 2013

AbstractThe polar regions are experiencing rapid climate change with implications for terrestrial ecosystems. Here, despite limited knowledge, we make some early predictions on soil invertebrate community responses to predicted twenty‐first century climate change. Geographic and environmental differences suggest that climate change responses will differ between the Arctic and Antarctic. We predict significant, but different, belowground community changes in both regions. This change will be driven mainly by vegetation type changes in the Arctic, while communities in Antarctica will respond to climate amelioration directly and indirectly through changes in microbial community composition and activity, and the development of, and/or changes in, plant communities. Climate amelioration is likely to allow a greater influx of non‐native species into both the Arctic and Antarctic promoting landscape scale biodiversity change. Non‐native competitive species could, however, have negative effects on local biodiversity particularly in the Arctic where the communities are already species rich. Species ranges will shift in both areas as the climate changes potentially posing a problem for endemic species in the Arctic where options for northward migration are limited. Greater soil biotic activity may move the Arctic towards a trajectory of being a substantial carbon source, while Antarctica could become a carbon sink.
The biodisposition and hypertrichotic effects of bimatoprost in mouse skin
Authors: Woodward David F. , Tang Elaine S.‐H. , Attar Mayssa , Wang Jenny W. 
Published: January 2013

AbstractStudies on bimatoprost were performed with two objectives: (i) to determine whether bimatoprost possesses hair growth‐stimulating properties beyond eyelash hypertrichosis and (ii) to investigate the biodisposition of bimatoprost in skin for the first time. Bimatoprost, at the dose used clinically for eyelash growth (0.03%) and given once daily for 14 days, increased pelage hair growth in C57/black 6 mice. This occurred as a much earlier onset of new hair growth in shaved mice and the time taken to achieve complete hair regrowth, according to photographic documentation and visual assessment. Bimatoprost biodisposition in the skin was determined at three concentrations: 0.01%, 0.03% and 0.06%. Dose‐dependent Cmax values were obtained (3.41, 6.74, 12.3 μg/g tissue), and cutaneous bimatoprost was well maintained for 24 h following a single dose. Bimatoprost was recovered from the skin only as the intact molecule, with no detectable levels of metabolites. Thus, bimatoprost produces hypertrichosis as the intact molecule.
Sedimentary facies and biofacies of theTorinosuLimestone in theTorinosu area,KochiPrefecture,Japan
Authors: Ohga Hiromichi , Kołodziej Bogusław , Nose Martin , Schmid Dieter U. , Takayanagi Hideko , Iryu Yasufumi 
Published: January 2013

AbstractTheTorinosuLimestone represents carbonate platform deposits in a foreland basin, the sedimentary setting of which is highly different from those of well‐knownLateJurassic reefs in the westernTethys that developed on shelf areas of continental margins and intra‐Tethyan platforms. Sedimentological and paleontological analyses were conducted on a 55.5 m‐thickUpperJurassic–LowerCretaceous (Tithonian–Berriasian) carbonate sequence (TorinosuLimestone) at theEasternHitotsubuchiQuarry,KochiPrefecture,SouthwestJapan. The carbonate sequence is composed of two sections that are separated by a subaerial exposure surface. Two and three depositional units have been defined in the lower and upper sections, respectively, based on changes in lithology and the biotic composition of the carbonates; they are numbered from 1 to 5, in ascending order. Calcified demosponges (stromatoporoids and a chaetetidChaetetopsis crinita) are abundant in three units (2, 3, and 5), in which microencrusters (mostlyLithocodium aggregatumandBacinella irregularis) and microbialites are also common to abundant. Although most of them are para‐allochthonous,in‐situbranching stromatoporoids are found on and above the subaerial exposure surface (unit 3). Corals are less common, poorly diverse, and primarily represented by the familyMicrosolenidae. Siliciclastic grains occur in all units, but they are particularly common in units 1 and 4. The co‐occurrence of theLithocodium–Bacinellaassociation, which is typical of oligotrophic or moderately mesotrophic shallow‐water environments, with microsolenids, which are indicative of high nutrient levels and/or low‐light intensity due to high turbidity, suggests repeated changes in nutrient levels associated with terrigenous input. Based on lithology, biotic composition, and succession, we infer that sea‐level changes and related terrigenous input controlled the sedimentary environment of the studied carbonate sequence.
Altered species interactions at forest edges: contrasting edge effects on bumble bees and their phoretic mite loads in temperate forest remnants
Authors: Ewers Robert M. , Bartlam Scott , Didham Raphael K. 
Published: January 2013

Abstract

The way in which species interactions are altered at habitat edges is an emerging concern in conservation biology, with some theories predicting edge‐affected habitats to be less stable and exhibit intensified species interactions relative to interior habitats. One little‐studied interaction is phoresy, where an individual of one species attaches itself to an individual of another species for the purpose of dispersal. Bumble bees (Bombus spp.) are important crop pollinators around the world and at least 10 species of phoretic mites have been associated with various bumble bee species.
Here, we investigated changes in the abundance of the introduced European B. terrestris across forest‐grassland edges in the Southern Alps of New Zealand, and concomitant changes in the phoretic mite loads on these mobile pollinators.
Bumble bees penetrated up to 250 m inside forest fragments, with abundance declining with distance from the anthropogenic matrix habitat. By contrast, phoretic mite loads increased towards the forest interior. Overall, phoretic mite loads on B. terrestris were greatest in the forest canopy, suggesting that this species interaction is intensified in natural habitat compared to that in the anthropogenic land use surrounding forest fragments.
Our data indicate that phoretic loads on bumble bees are elevated in forest canopies. The functional significance of altered bumble bee – mite interactions for pollination services at forest edges remains to be tested.
Motivational interviewing and exercise programme for community‐dwelling older persons with chronic pain: a randomised controlled study
Authors: Tse Mimi MY , Vong Sinfia KS , Tang Shuk Kwan 
Published: January 2013

Aims and objectivesTo examine the effectiveness of an integrated motivational interviewing and physical exercise programme on pain, physical and psychological function, quality of life, self‐efficacy, and compliance with exercise for community‐dwelling older persons with chronic pain.BackgroundChronic pain is common among older persons. Indeed, motivation for managing pain is poor, and may cause negative consequences. Motivational interviewing maybe effective in treating chronic pain.DesignSingle‐blinded randomised control study.MethodsOlder persons with chronic pain (n = 56) were recruited from two elderly community centres. They were blinded from the group allocation. The programme was conducted by an motivational interviewing‐trained physiotherapist and registered nurses. Participants in the experimental group received an 8‐week integrated motivational interviewing and physical exercise programme, while the control group received regular activities in the centre. Motivational interviewing used open‐ended questions to encourage participants to express and recognise their pain and behaviours and professional feedback was given accordingly. Pain intensity, pain self‐efficacy, anxiety, happiness, depression, mobility and quality of life were measured before and after the motivational interviewing and physical exercise programme. Attendance and compliance rate of the programme was calculated in the experimental group.ResultsSignificant improvements in pain intensity, pain self‐efficacy, anxiety, happiness and mobility after the motivational interviewing and physical exercise programme (all p < 0·05) for experimental group, while no significant improvement in control group except on the happiness scale. Regarding group differences in the outcome measures, the change scores on pain intensity, state anxiety and depression were significantly better in the experimental group.ConclusionMotivational interviewing and physical exercise programme is effective in improving pain, physical mobility, psychological well‐being and self‐efficacy for community‐dwelling older persons with chronic pain.Relevance to clinical practiceMotivational interviewing is a feasible counselling technique whose content can be modified based on target group to change maladaptive behaviours, elicit ambivalences and enhance self‐efficacy for making changes. Thus, promoting motivational interviewing and physical exercise programme to older persons with pain is effective and important.
The effect of oral training on vital signs of premature infants
Authors: Fan Ya‐Chi , Chung Shih‐Chi , Yang Peng‐Hong , Hung Chao‐Chia , Li Hsiao‐Juan 
Published: January 2013

Aims and objectivesThis study aimed to develop an applicable oral training protocol and test its effects on vital sign stabilisation in premature infants.BackgroundOral training improves the feeding behaviour of premature infants. However, the inconsistencies of oral training procedures in previous studies obscure the interventional effect of oral training on vital sign stabilisation in premature infants.DesignTrue experimental design.MethodsSixty premature infants with a gestational age <33 weeks were recruited and randomly assigned to the oral training or control group.ResultsHeart rate, respiratory rate and oxygen saturation tended to improve in the oral training group compared to those in the control group. However, the intergroup differences with respect to vital signs before and after feeding were not statistically significant.ConclusionsFurther studies comparing protocols with different measurement points and durations are suggested.
The seminiferous epithelial cycle and microanatomy of the koala (Phascolarctos cinereus) and southern hairy‐nosed wombat (Lasiorhinus latifrons) testis
Authors: Oishi Motoharu , Takahashi Mei , Amasaki Hajime , Janssen Tina , Johnston Stephen D. 
Published: January 2013

AbstractThe koala (Phascolarctos cinereus) and southern hairy‐nosed wombat (Lasiorhinus latifrons) are iconic Australian fauna that share a close phylogenetic relationship but there are currently no comparative studies of the seminiferous epithelial cell or testicular microanatomy of either species. Koala and wombat spermatozoa are unusual for marsupials as they possess a curved stream‐lined head and lateral neck insertion that superficially is similar to murid spermatozoa; the koala also contains Sertoli cells with crystalloid inclusions that closely resemble the Charcot–Bottcher crystalloids described in human Sertoli cells. Eighteen sexually mature koalas and four sexually mature southern hairy‐nosed (SHN) wombats were examined to establish base‐line data on quantitative testicular histology. Dynamics of the seminiferous epithelial cycle in the both species consisted of eight stages of cellular association similar to that described in other marsupials. Both species possessed a high proportion of the pre‐meiotic (stages VIII, I – III; koala – 62.2 ± 1.7% and SHN wombat – 66.6 ± 2.4%) when compared with post‐meiotic stages of the seminiferous cycle. The mean diameters of the seminiferous tubules found in the koalas and the SHN wombats were 227.8 ± 6.1 and 243.5 ± 3.9 μm, respectively. There were differences in testicular histology between the species including the koala possessing (i) a greater proportion of Leydig cells, (ii) larger Sertoli cell nuclei, (iii) crystalloids in the Sertoli cell cytoplasm, (iv) a distinctive acrosomal granule during spermiogenesis and (v) a highly eosinophilic acrosome. An understanding of the seminiferous epithelial cycle and microanatomy of testis is fundamental for documenting normal spermatogenesis and testicular architecture; recent evidence of orchitis and epididymitis associated with natural chlamydial infection in the koala suggest that this species might be useful as an experimental model for understanding Chlamydia induced testicular pathology in humans. Comparative spermatogenic data of closely related species can also potentially reflect evolutionary divergence and differences in reproductive strategies.
Impact of a temporary stoma on patients' everyday lives: feelings of uncertainty while waiting for closure of the stoma
Authors: Danielsen Anne K , Soerensen Erik E , Burcharth Kirsten , Rosenberg Jacob 
Published: January 2013

Aims and objectivesTo examine patients′ experiences of impact of a temporary stoma on their everyday life. Furthermore, we wanted to generate new knowledge and comprehension of learning how to live with a temporary stoma.BackgroundThere are many aspects, largely unexplored, that may influence patients′ adaptation to life with a stoma. Amongst these, being in a temporary state is relatively unexplored and may have a restrictive impact on patients′ adaptation.DesignFocus group interviews conducted with seven patients with temporary stoma were set up with a hermeneutic phenomenological perspective.MethodsData were processed using qualitative content analysis.ResultsThe creation of a temporary stoma led to feelings of uncertainty related to being in an undecided situation. Stoma creation led to feelings of stigma and worries about disclosure. Patients proposed group‐based patient education with lay educators with a stoma to make sure that information about the stoma was based on real‐life experiences.ConclusionsCreation of a temporary stoma was linked to uncontrollable feelings of uncertainty. Professionals should assist patients with focus on coping strategies, as they are associated with positive re‐evaluation of the situation. Introducing a coherent and structured learning environment involving both lay educators with a stoma and group‐based learning would be useful.Relevance to clinical practiceNurses and other health professionals should support patients in problem‐focused coping strategies. These strategies may be supported when patients have a high sense of coherence. Furthermore, patients′ disclosure of the stoma as a way to master feelings of stigma should be facilitated. Stoma education is central for patients, and group‐based learning that involves lay educators with a stoma is seen as a way to empower patients with temporary stomas.
The development and psychometrical evaluation of a set of instruments to evaluate the effectiveness of diabetes patient education
Authors: Duprez Veerle , De Pover Marleen , De Spiegelaere Marc , Beeckman Dimitri 
Published: January 2013

Aims and objectivesTo develop a set of psychometrically sound instruments to assess knowledge, self‐management and self‐efficacy of diabetic patients. Furthermore, a survey to evaluate the satisfaction about diabetes education for patients was developed and tested.BackgroundTreatment and secondary prevention of diabetes require a complex combination of care components. Patients' education has been accepted to improve diabetes knowledge, self‐management and self‐efficacy. Psychometrically sound instruments are needed to measure these patient‐centred outcomes.DesignPsychometric instrument validation.MethodsThe first phase included a systematic literature review to develop the instruments. Content validity was evaluated using a two‐round Delphi procedure involving diabetes experts. The content validity of the instruments was excellent. In a second phase, a convenience sample of 188 diabetic patients in two hospitals in one specific care region in Belgium participated in the psychometric evaluation. The criterion‐related validity and internal consistency reliability were evaluated.ResultsThe study produced a 21‐item knowledge instrument, reflecting knowledge about ‘glycemic control’ and ‘medico‐social management aspects’. The self‐management instrument included 32 statements, reflecting ‘treatment and compliance’ and ‘general lifestyle’. The self‐efficacy instrument included 30 items, reflecting ‘nutrition’, ‘treatment’ and ‘regimen’. The patient satisfaction survey included 36 items, reflecting satisfaction about the relationship among the diabetes specialist, the diabetes educator, podiatrist and dietician.ConclusionsAn instrument set with sound psychometric characteristics was developed to assess knowledge, self‐management and self‐efficacy of diabetic patients. Future studies should focus on the association between the instrument outcomes and clinical patient outcomes.Relevance to clinical practiceThe current instrument can support the design of educational interventions and training programmes and reduce inconsistencies in the information that patients receive. Furthermore, the instruments can be used for benchmarking the quality of diabetic patient education.
‘Talkin’ ‘Bout My Generation’: Political Orientations and Activities of a Cohort of Canadian University Students in the Mid‐Sixties
Authors: Grayson J Paul 
Published: January 2013

AbstractWhile Canadian scholars have documented some of the beliefs and behaviours of student activists in the 1960s, little has been said of the ‘average’ Canadian university student. As a result, this article deals with the political orientations and activities of students who entered Glendon College, York University, in 1963 and who graduated by 1967. It will be shown that upon entry to the university this cohort of students was primarily Liberal. Despite fundamental changes that were occurring at a macro‐social level, by and large, the distribution of students’ political orientations was the same in 1967 as it had been in 1963. The virtual absence of collective action with a political objective was consistent with this reality.