bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early effects of Staphylococcus aureus biofilm secreted products on inflammatory responses of human epithelial keratinocytes
Authors: Tankersley Amy , Frank Mark Barton , Bebak Melissa , Brennan Robert 
Published: June 2014

AbstractBackgroundChronic wounds such as diabetic foot ulcers, pressure ulcers, and venous leg ulcers contribute to a considerable amount of mortality in the U.S. annually. The inability of these wounds to heal has now been associated with the presence of microbial biofilms. The aim of this study was to determine if products secreted byS. aureusbiofilms play an active role in chronic wounds by promoting inflammation, which is a hallmark of chronic wounds.MethodsIn vitroexperiments were conducted to examine changes in gene expression profiles and inflammatory response of human epithelial keratinocytes (HEKa) exposed to products secreted byS. aureusgrown in biofilms or products secreted byS. aureusgrown planktonically.ResultsAfter only two hours of exposure, gene expression microarray data showed marked differences in inflammatory, apoptotic, and nitric oxide responses between HEKa cells exposed toS. aureusbiofilm conditioned media (BCM) and HEKa cells exposed toS. aureusplanktonic conditioned media (PCM). As early as 4 hours post exposure, ELISA results showed significant increases in IL-6, IL-8, TNFα, and CXCL2 production by HEKa cells exposed to BCM compared to HEKa cells exposed to PCM or controls. Nitric oxide assay data also showed significant increases in nitric oxide production by HEKa cells treated with BCM compared to HEKa cells treated with PCM, or controls.ConclusionsTaken together, these results support and extend previous findings that indicate products secreted byS. aureusbiofilms directly contribute to the chronic inflammation associated with chronic wounds.
On the tripled fixed point and tripled coincidence point theorems in fuzzy normed spaces
Authors: Saadati Reza , Kumam Poom , Jang Sun Young 
Published: June 2014

Abstract
Recently, Abbas et al. (Fixed Point Theory Appl. 2012:187, 2012) proved tripled fixed point and tripled coincidence point theorems in intuitionistic fuzzy normed spaces. Saadati and Park proved that the topology

τ

(
μ
,
ν
)

generated by an intuitionistic fuzzy normed space

(
X
,
μ
,
ν
,
∗
,
⋄
)

coincides with the topology

τ
μ

generated by the generalized fuzzy normed space

(
X
,
μ
,
∗
)

, and thus the results obtained in intuitionistic fuzzy normed spaces are immediate consequences of the corresponding results for fuzzy normed spaces. In this paper, we improve and extend the results presented by Abbas et al. to ℒ-fuzzy normed spaces.

MSC: 47H09, 47H10, 54H25.
Organization and evolution of a novel cervid satellite DNA with yeast CDEI-like repeats
Authors: Hsieh Lei-Jiau , Cheng Ya-Ming , Wang Yi-Chun , Lin Chyi-Chyang , Li Yueh-Chun 
Published: June 2014

AbstractBackgroundIt has been proposed that pericentromeric satellite DNA arises from the progressive proximal expansion of ancient centromeric DNA. In an attempt to recover putative ancestral centromeric DNA, we microdissected the pericentromeric/centromeric DNA from the chromosome X + 3 of Indian muntjac (Muntiacus muntjak vaginalis) and constructed a microclone-library of the X + 3 centromeric DNA.ResultsA new cervid satellite DNA element, designated as satellite VI, was isolated from this library. Fluorescence in situ hybridization (FISH) studies revealed that satellite VI is predominately located on the distal pericentromeric region of the Indian muntjac chromosome X + 3 and on the pericentromeres of several Old World deer species studied. Its sequence is organized as 11-bp monomeric (ATCACGTGGGA) tandem repeats. Further sequencing on a BAC clone of Indian muntjac harboring this repeat showed that an array of this repeat stretches over approximately 5 kb followed by approximately 3 kb of interspersed repetitive sequences, such as long interspersed elements (LINEs), short interspersed elements (SINEs), and long terminal repeats (LTRs).ConclusionsBased on the chromosomal localization, genomic and sequence organization, and copy numbers of satellite VI in deer species studied, we postulate that this newly found satellite DNA could be a putative ancient cervidic centromeric DNA that is still preserved in some Old World deer. Interestingly, the first eight nucleotides of the 11-bp monomeric consensus sequences are highly conserved and identical to the CDEI element in the centromere of the budding yeastSaccharomyces cerevisiae. The centromeric/pericentromeric satellite DNA harboring abundant copies of CDEI sequences is the first found in a mammalian species. Several zipper-like d (GGGA)2motifs were also found in the (ATCACGTGGGA)nrepeat of satellite VI DNA. Whether the satellite VI is structurally and functionally correlated with the CDEI of centromere of budding yeast and whether a zipper-like structure forms in satellite VI require further studies.
Randomized, Phase III Trial of First-Line Figitumumab in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone in Patients With Advanced Non–Small-Cell Lung Cancer
Authors: Langer Corey J. , Novello Silvia , Park Keunchil , Krzakowski Maciej , Karp Daniel D. , Mok Tony , Benner Rebecca J. , Scranton Judith R. , Olszanski Anthony J. , Jassem Jacek 
Published: June 2014

Purpose Figitumumab (CP-751,871), a fully human immunoglobulin G2 monoclonal antibody, inhibits the insulin-like growth factor 1 receptor (IGF-1R). Our multicenter, randomized, phase III study compared figitumumab plus chemotherapy with chemotherapy alone as first-line treatment in patients with advanced non–small-cell lung cancer (NSCLC). Patients and Methods Patients with stage IIIB/IV or recurrent NSCLC disease with nonadenocarcinoma histology received open-label figitumumab (20 mg/kg) plus paclitaxel (200 mg/m2) and carboplatin (area under the concentration-time curve, 6 mg · min/mL) or paclitaxel and carboplatin alone once every 3 weeks for up to six cycles. The primary end point was overall survival (OS). Results Of 681 randomly assigned patients, 671 received treatment. The study was closed early by an independent Data Safety Monitoring Committee because of futility and an increased incidence of serious adverse events (SAEs) and treatment-related deaths with figitumumab. Median OS was 8.6 months for figitumumab plus chemotherapy and 9.8 months for chemotherapy alone (hazard ratio [HR], 1.18; 95% CI, 0.99 to 1.40; P = .06); median progression-free survival was 4.7 months (95% CI, 4.2 to 5.4) and 4.6 months (95% CI, 4.2 to 5.4), respectively (HR, 1.10; P = .27); the objective response rates were 33% and 35%, respectively. The respective rates of all-causality SAEs were 66% and 51%; P < .01). Treatment-related grade 5 adverse events were also more common with figitumumab (5% v 1%; P < .01). Conclusion Adding figitumumab to standard chemotherapy failed to increase OS in patients with advanced nonadenocarcinoma NSCLC. Further clinical development of figitumumab is not being pursued.
Underuse of Trimodality Treatment Affects Survival for Patients With Inflammatory Breast Cancer: An Analysis of Treatment and Survival Trends From the National Cancer Database
Authors: Rueth Natasha M. , Lin Heather Y. , Bedrosian Isabelle , Shaitelman Simona F. , Ueno Naoto T. , Shen Yu , Babiera Gildy 
Published: June 2014

Purpose To analyze factors that predict the use of trimodality treatment (chemotherapy, surgery, and radiation therapy [RT]) and evaluate the impact that trimodality treatment use has on survival for patients with inflammatory breast cancer (IBC). Methods Using the National Cancer Data Base, patients who underwent surgical treatment of nonmetastatic IBC from 1998 to 2010 were identified. We collected demographic, tumor, and treatment data and analyzed treatment and survival trends over time. Logistic regression and Cox proportional hazard models were used to examine factors predicting treatment and survival. Results We identified 10,197 patients who fulfilled study criteria. The use of trimodality therapy fluctuated annually (58.4% to 73.4%). Patients who were older, diagnosed earlier in the study period, lived in regions of the country outside of the Midwest, had lower incomes or public insurance, and had a higher comorbid score were significantly less likely to receive trimodality therapy (all P < .05). Five- and 10-year survival rates were highest among patients receiving trimodality treatment (55.4% and 37.3%, respectively) compared with patients who received the combination of surgery plus chemotherapy, surgery plus RT, or surgery alone. After adjusting for potential confounding variables, use of trimodality therapy remained a significant independent predictor of survival. Conclusion Underutilization of trimodality therapy negatively impacted survival for patients with IBC. The use of trimodality therapy increased marginally with time, but there remain significant factors associated with differences in use of trimodality treatment. We have identified specific barriers to care that may be targeted to improve treatment delivery and potentially improve patient outcomes.
An Investigation of Moisture Gradient in Wood during Drying Using X-Ray Radiation and Numeric Methods
Authors: Yu Le , Hao Xiaofeng , Cai Liping , Shi Sheldon Q. , Jiang Jiali , Lu Jianxiong 
Published: June 2014

Abstract
The moisture gradient in wood is a characteristic of major interest in lumber drying. Two methods, an ovendry slicing method and an X-ray scanning method, were used to examine moisture gradients in wood during the drying of Chinese fir (Cunninghamia lanceolata). The results of the comparison between these two methods confirmed that X-ray radiation can be used to monitor moisture distribution during the drying of Chinese fir. Compared with the moisture content (MC) values obtained by the ovendry slicing method, the X-ray scanning method is capable of determining MC to within ±12.9 percent. Using a control volume approach, a numeric model for estimating the moisture gradient in wood during drying was developed in this work. The validation tests indicated that the model can be used to estimate moisture gradients during the drying of Chinese fir and is capable of predicting moisture distribution to within ±12.6 percent.
Women's Social Communication About IUDs: A Qualitative Analysis
Authors: Anderson Nora , Steinauer Jody , Valente Thomas , Koblentz Jenna , Dehlendorf Christine 
Published: June 2014

ContextFew U.S. women use an IUD, despite the method's efficacy and ease of use. While studies have found that misconceptions about IUDs are prevalent, few have examined the influence of women's social networks on perceptions of the method.MethodsTwenty‐four interviews and three focus groups (comprising 14 participants) were conducted in 2013 with a diverse sample of women aged 15–45 recruited from family planning clinics and the community in San Francisco. Half of participants had used IUDs. Women were asked about their social communication concerning contraceptives, particularly IUDs, and about the content of the information they had received or given. Transcripts were analyzed using a modified grounded theory approach to identify themes of interest.ResultsWomen reported that communication with female friends and family members was a valued means of obtaining information about contraceptives, and that negative information (which often was incorrect) was more prevalent and memorable than positive information in such communication. Women heard about negative experiences with IUDs from social contacts and television commercials; clinicians were a major source of positive information. Women who had never used IUDs expressed interest in learning about potential side effects and how IUDs feel, while users reported emphasizing to friends and family the method's efficacy and ease of use.ConclusionsMisinformation and negative information about IUDs are prevalent in social communication, and the information transmitted through social networks differs from the information never‐users wish to receive. Findings support the creation of peer‐led interventions to encourage IUD users to share positive personal experiences and evidence‐based information.
Prevalence of Disability According to Multimorbidity and Disease Clustering: A Population-Based Study
Authors: Marengoni Alessandra , Angleman Sara , Fratiglioni Laura 
Published: June 2014

Background The prevalence of chronic diseases has increased with population ageing, and research has attempted to elucidate the correlation between chronic diseases and disability. However, most studies in older populations have focused on the effect of single disabling conditions, even though most older adults have more than one chronic disease (multimorbidity). Objective The aims of this study were to evaluate the association of disability with disease, in terms of multimorbidity and specified pairs of diseases, in a population-based study of older adults. Materials and Methods Using the Kungsholmen Project, we estimated the prevalence of disability by the number of chronic diseases, disease status by organ systems, and in specific pairs of chronic conditions, in a Swedish population ( n=1,099; ≥77 years). Disability was defined as need of assistance in at least one activity of daily living (Katz index). Results Functional disability was seen in 17.9% of participants. It increased as the number of chronic diseases increased. The prevalence of disability varied greatly amongst specific pairs of diseases: from 6.7% in persons affected by hypertension and atrial fibrillation to 82.4% in persons affected by dementia and hip fracture. In multivariate logistic regression models, the disease pairs that were significantly associated with the highest increased relative odds of disability contained dementia (dementia–hip fracture, dementia–CVD, and dementia–depression). Conclusions Our findings suggest specific pairs of diseases are much more highly associated with disability than others, particularly diseases coupled with dementia. This knowledge may improve prevention of disablement and planning of resource distribution.
Diabetes Alone should not be a Reason for Withholding Adjuvant Chemotherapy for Stage III Colon Cancer
Authors: van Waalwijk Maren A. , van de Schans Saskia A. M. , Haak Harm R. , Extermann Martine , Dercksen Wouter M. W. , Janssen-Heijnen Maryska L. G. 
Published: June 2014

Background With increasing prevalence of diabetes mellitus and colon cancer, the number of patients suffering from both diseases is growing, and physicians are being faced with complicated treatment decisions. Objective To investigate the association between diabetes and treatment/course of stage III colon cancer and the association between colon cancer and course of diabetes. Materials and Methods Additional information was collected from the medical records of all patients with both stage III colon cancer and diabetes ( n=201) and a random sample of stage III colon cancer patients without diabetes ( n=206) in the area of the population-based Eindhoven Cancer Registry (1998–2007). Results Colon cancer patients without diabetes were more likely to receive adjuvant chemotherapy compared with diabetic colon cancer patients (OR 1.8; 95% CI 1.2–2.7). After adjustment for age, this difference was borderline significant (OR 1.6; 95% CI 1.0–2.6). Diabetic patients did not have: significantly more side-effects from surgery or adjuvant chemotherapy; more recurrence from colon cancer; significantly shorter time interval until recurrence; or a poorer disease-free survival or overall survival. Age and withholding of adjuvant chemotherapy were most predictive of all-cause mortality. After colon cancer diagnosis, the dose of antiglycaemic medications was increased in 22% of diabetic patients, resulting in significantly lower glycaemic indexes than before colon cancer diagnosis. Conclusions Since diabetic patients did not have more side-effects of adjuvant chemotherapy, and adjuvant chemotherapy had a positive effect on survival for both patients with and without diabetes, diabetes alone should not be a reason for withholding adjuvant chemotherapy.
The ‘Everyday Work’ of Living with Multimorbidity in Socioeconomically Deprived Areas of Scotland
Authors: O'Brien Rosaleen , Wyke Sally , Watt Graham G.C.M. , Guthrie Bruce , Mercer Stewart W. 
Published: June 2014

Background Multimorbidity is common in patients living in areas of high socioeconomic deprivation and is associated with poor quality of life, but the reasons behind this are not clear. Exploring the ‘everyday life work’ of patients may reveal important barriers to self-management and wellbeing. Objective To investigate the relationship between the management of multimorbidity and ‘everyday life work’ in patients living in areas of high socioeconomic deprivation in Scotland, as part of a programme of work on multimorbidity and deprivation. Design Qualitative study: individual semi-structured interviews of 14 patients (8 women and 6 men) living in deprived areas with multimorbidity, exploring how they manage. Analysis was continuous and iterative. We report the findings in relation to everyday life work. Results The in-depth analysis revealed four key themes: (i) the symbolic significance of everyday life work to evidence the work of being ‘normal’; (ii) the usefulness of everyday life work in managing symptoms; (iii) the impact that mental health problems had on everyday life work; and (iv) issues around accepting help for everyday life tasks. Overall, most struggled with the amount of work required to establish a sense of normalcy in their everyday lives, especially in those with mental–physical multimorbidity. Conclusions Everyday life work is an important component of self-management in patients with multimorbidity in deprived areas, and is commonly impaired, especially in those with mental health problems. Interventions to improve self-management support for patients living with multimorbidity may benefit from an understanding of the role of everyday life work.
Indonesians in Saudi Arabia: Worhsip and Work
Authors: Husson Laurence 
Published: June 2014

This article, which opens a new line of research, is intended to make a first assessment of the consequences of Indonesian migration to saudi Arabia, in particular during the first half of the 2Oth century-a period when the immigration is bound up with the pilgrimage from which Saudi Arabia draws a large part of its revenues. It must be added that while documentary evidence and partial studies on this period exist, it turns out that documentation on the contemporary period is scarce. This article also is concerned with describing the evolution of certain striking aspects of the close relation between the pilgrimage to Mecca and Indonesian migrants looking for work. We need to consider the methods of hiring labor, the networks involved in recruiting it, the organization of travel, as well as the increasing indebtedness of the migrants through intermediaries who, more and more professionally, arrange these attempts to live abroad, prompted in many cases by the same desire for wealth.DOI: 10.15408/sdi.v4i4.767
Al-Ḥājj ‘Umar Sa‘īd Shukrū Amīnūtū: Ḥayātu wa Kifāhuh wa Afkāruh
Authors: Daulay Agus Salim 
Published: June 2014

HOS Tjokroaminoto, to this day, tends to be considered as a Sarekat Islam (Islam Union) important figure only, whereas he was one of the actors who contributed to the formation of Indonesian modern history.DOI: 10.15408/sdi.v4i4.768
NU: Islam Tradisional dan Modernitas di Indonesia
Authors: Azra Azyumardi 
Published: June 2014

As stated by Abdurrahman Wahid in his introduction, the book under discussion is the first one written in English, not in the Indonesian language, that discusses the Nahdatul Ulama (NU). This is of course very surprising, since the NU is one of the largest Muslim organizations in Indonesia.DOI: 10.15408/sdi.v4i4.770
Peradaban Islam Melayu
Authors: Burhanudin Jajat 
Published: June 2014

"Civilization", the term employed as the main title of the book under review, is of spesific significance to us here. The term has appeared only in recent scholarly works on Southeast Asian Islam, especially those written by oreintalists.This paper is a review of the book Mohd. Taib Osman, (ed.), Islamic Civilization in the Malay World (Kuala Lumpur and Istanbul: Language and Library Board and the Research Centre for Islamic History, Art, and Culture, 1997).DOI: 10.15408/sdi.v5i1.763
“The Clash of Civilization”: A Prognosis of the Future or the Lure of the Past
Authors: Abdullah Taufik 
Published: June 2014

This article is seen as one response to the Clash of Civilization thesis and wanted to test the accuracy of the analysis of Samuel Huntington back in the context of the uniqueness of Islam in Indonesia.The story begins when Samuel P. Huntington - the famous political scientist from the highly prestigious Harvard Uinversity and a citizen of the most powerful nation - writes an article, entitled "The Clash of Civilization?" in foreign Affair.DOI: 10.15408/sdi.v5i2.754
Al-Ma‘had al-Turāthī wa al-Ta’hīl al- Mihanī:Tajribah Nūr al-Jadīd al-Tawaqu‘i al-Mustaqbal
Authors: Murodi Murodi , Wahid Hamid. W 
Published: June 2014

This paper will discuss the characteristics of pesantren education in relation to vocational education, background and objectives by taking the case of boarding Nurul Jadid, Karanganyar, Paiton, Probolinggo, East Java.Unlike what Abdurrahman Wahid once argues, since the 1970's, the pesantren, traditional Islamic boarding schools, have not been construed as unique and closed institution, but have become cultural institution actively responding to social changes. Recently pesantren have had no choice but to open their doors to the DOI: 10.15408/sdi.v5i2.755
Hasan Bandunj: al-Mufakir al-Faqih al-Muthir li Jidal
Authors: Suyanta Sri 
Published: June 2014

A. Hasan Bandung merupaka salah satu tokoh pembaharu modernis yang dikenal dengan sikapnya yang kontroversial dan polemis. Tulisan yang menggambarkan biografi intelektual A. Hasan ini, khususnya dalam kaitan pemikiran fiqh, dimaksudkan untuk melihat kekayaan khazanah pemikiran modern dalam Islam Indonesia.DOI: 10.15408/sdi.v5i3.742
Al-Tafkīr ḥaul Makānah al-Mar’ah bi Indūnīsiyā baḥth fī Mawqif al-Islām min al-Ḥarkāt al-Nisā’īyah fī al-Qarnayn al-Tāsi’ ‘Ashr wa al-‘Ishrīn al-Milādiyīn
Authors: Munawwaroh Junaidah 
Published: June 2014

the discourse concerning feminism in Indonesian Muslim society is relatively recent. The emergence of such a movement only goes back to the early twentieth century, when R.A Kartini, a daughter of Jepara Resident, struggled for an equal position for man and women in public life. it seems that the movement has tried to respon a particular challenge faced by most women in the Dutch-East Indies who have been discriminated againts and denied access to education. as the movement speards, the discourse on gender rises to become an important issue among muslims in Indonesia, particularly in academic sphere. It grows rapidly with more extensive and subtantial topics of discussion.DOI: 10.15408/sdi.v6i1.748
Al-Tafkīr al-Fiqhīyah ‘inda Nahdlatul Ulama
Authors: Ariev Hodri 
Published: June 2014

Since its establish in 1926, Nahdatul Ulama (NU) has been known as a socio-religious organization that bases its thought and practice on the four outstanding Islamic law school: Maliki, Shafi'i and Hanafi. However, during the third NU's Congress in Surabaya, East JAva, NU declared itself to affiliated to Shafi its school only. The congress was special because this declaration was incorporated formally into its constitution; the Congress also resulted in the creation of a special forum to discuss religious legal problems (bahtsul masail Ar. bahth al-masa'il) faced by ummah. To date not less than 420 decisions have been produced by this forum that adress various problems such as family, politics, economy, education, ritual and so forth.DOI: 10.15408/sdi.v6i1.749