bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Novel One‐Pot Ionic Liquid Promoted Synthesis of Benzo[a]phenothiazine Derivatives
Authors: Yadav Ashok K. , Gupta Manisha 
Published: May 2015

Abstractvia condensation reactions of 1,4‐naphthoquinones (II) with 2‐aminobenzenethiols or their Zn‐salts
ChemInform Abstract: Synthesis of Saturated Benzodioxepinone Analogues: Insight into the Importance of the Aromatic Ring Binding Motif for Marine Odorants.
Authors: Plummer Christopher M. , Gericke Robert , Kraft Philip , Raynor Aaron , Froese Jordan , Hudlicky Tomas , Rook Trevor J. , Jones Oliver A. H. , Huegel Helmut M. 
Published: May 2015

AbstractThe first saturated benzodioxepinone analogues of Calone 1951 ®, an important artificial fragrance, are synthesized via two different pathways.
ChemInform Abstract: Direct Radical Acetoxyphosphorylation of Styrenes Mediated by Manganese(III).
Authors: Zhou Shao‐Fang , Li Da‐Peng , Liu Kui , Zou Jian‐Ping , Asekun Olayinka Taiwo 
Published: May 2015

AbstractThe reaction of various styrenes and some other alkenes with phosphorus compounds (II) is investigated under optimized conditions.
ChemInform Abstract: 3‐(3,4,5‐Trimethoxyphenylselenyl)‐1H‐indoles and Their Selenoxides as Combretastatin A‐4 Analogues: Microwave‐Assisted Synthesis and Biological Evaluation.
Authors: Wen Zhiyong , Xu Jingwen , Wang Zhiwei , Qi Huan , Xu Qile , Bai Zhaoshi , Zhang Qian , Bao Kai , Wu Yingling , Zhang Weige 
Published: May 2015

AbstractMost of the new selenylindole derivatives (III) and their selenoxides (IV) exhibit significant antiproliferative activities against three human cancer cell lines (gastric adenocarcinoma (SGC7901), oral carcinoma (KB) and fibrosarcoma (HT1080)).
ChemInform Abstract: A Catalytic Asymmetric Total Synthesis of (—)‐Perophoramidine.
Authors: Trost B. M. , Osipov M. , Krueger S. , Zhang Y. 
Published: May 2015

AbstractThe asymmetric key step of the new protocol is the molybdenum‐catalyzed allylic alkylation of the oxindole (II) to give (III) with high enantioselectivity.
ChemInform Abstract: Naphthalenones and Isocoumarins from a Costa Rican Fungus Xylariaceae sp. CR1546C.
Authors: Kim Ki Hyun , Beemelmanns Christine , Murillo Catalina , Guillen Anny , Umana Loengrin , Tamayo‐Castillo Giselle , Kim Su‐Nam , Clardy Jon , Cao Shugeng 
Published: May 2015

Abstractisolation, structure elucidation, and biological activity of new compounds (I) and (II) along with eight related known compounds
ChemInform Abstract: Strong Red Emission in Eu3+/Bi3+ Ions Codoped CaWO4 Phosphors for White Light‐Emitting Diode and Field‐Emission Display Applications.
Authors: Du Peng , Krishna Bharat L. , Yu Jae Su 
Published: May 2015

AbstractCaWO4:xEu3+ (x = 0.01, 0.03, 0.05, 0.07, 0.09, 0.11) and CaWO4:0.08Eu3+/yBi3+ (y = 0.005, 0.01, 0.02, 0.03) phosphors are synthesized by solid state reactions of CaCO3, WO3, Eu2O3, and Bi2O3 (alumina crucibles, 1100 °C, 6 h in air).
ChemInform Abstract: Wide‐Band Excited LaBMoO6:Eu3+ Red Phosphor for White‐Light‐Emitting Diode.
Authors: Zhang Z. W. , Ma D. Q. , Yue Y. , Ma M. Z. , Liu R. P. 
Published: May 2015

AbstractThe new title phosphor is synthesized by solid state reaction of H3BO3, (NH4)6Mo7O24, La2O3, and Eu2O3 (900 °C, 4 h in air).
ChemInform Abstract: Reclamation of Reactive Metal Oxides from Complex Minerals Using Alkali Roasting and Leaching — An Improved Approach to Process Engineering
Authors: Sanchez‐Segado S. , Makanyire T. , Escudero‐Castejon L. , Hara Y. , Jha A. 
Published: May 2015

AbstractReview: 76 refs.
A multi‐infrastructure gateway for virtual drug screening
Authors: Jaghoori Mohammad Mahdi , van Altena Allard J. , Bleijlevens Boris , Ramezani Sara , Font Juan Luis , Olabarriaga Silvia D. 
Published: May 2015

SummaryIn computer‐aided drug design, software tools are used to narrow down possible drug candidates, thereby reducing the amount of expensive in vitro research, by a process called virtual screening. This process includes large computations that require advanced computing infrastructure; however, using rapidly evolving high‐performance computing platforms can be difficult for biochemists. In this paper, we present a science gateway for virtual screening that has been tailored to the specific needs of our local users. The gateway provides user‐friendly access to distributed computing infrastructures for high‐throughput experiments with a few clicks. Its design is based on the generic layer developed for another gateway for neuroimaging data analysis, including data and computation management, as well as support for its operation. To facilitate scalability, the system architecture allows for adding new computing platforms to the back‐end without affecting the front‐end, from which the user can dynamically choose the preferred infrastructure. This paper describes the user‐centered design process, the system architecture and a performance assessment using gLite grid, Hadoop, and a local cluster. The empirical results show considerable speed‐ups and ease of use, as well as user satisfaction. Copyright © 2015 John Wiley & Sons, Ltd.
Minimum‐cost virtual machine migration strategy in datacenter
Authors: Zhang Xinyan , Li Keqiu , Zhang Yong 
Published: May 2015

SummaryWith an explosive growth of the datacenter research, virtual machines migration aiming at optimization of virtual machines placement is a major technology of improving power efficiency and resource utilization in the datacenter. While recent studies have primarily focused on maximizing resource utilization or minimizing migration cost separately, there has been little attention on jointly taking these two objectives into account. In this paper, we present the optimization model taking minimum migration cost and maximum resource utilization with multi‐resources such as storage, bandwidth, CPU, and disk space into account. The optimization of our proposed model is non‐deterministic polynomial‐time hard. According to the model, we present an efficient approximate algorithm based on bin packing algorithm, called MinCost, to resolve our model and obtain a near‐optimal solution. Finally, the simulation results in this paper show that our model and algorithm is efficient. Copyright © 2015 John Wiley & Sons, Ltd.
A simple LED driver with low dimming switch stress
Authors: Lin Yu‐Liang , Leng Chung‐Ming , Wang Jian‐Min 
Published: May 2015

SummaryThis paper aims to investigate the low dimming switch stress of a light‐emitting diode (LED) driver. Most dimmable LED drivers contain a series dimming switch with a LED string to implement a pulse‐width modulation‐dimming function. However, this setup causes the dimming switch to suffer from high voltage stress in the dimming interval. To reduce the voltage stress of a dimming switch, a low switch stress scheme is presented. The dimming circuit is parallel with the LED string. Using proper arrangement and design of the parameters, the dimming circuit changes the feedback status, which results in the output driving voltage varying between a constant current and a fixed voltage operation. These two operating conditions also make the LED string turn on/off alternately and consequently and perform the dimming function. The dimming switch acts by altering the feedback path instead of cutting off the main power flow; hence, it does not need a power level switch. Details of the operating principles and design considerations are discussed in this study. A prototype boost converter was developed to verify the feasibility of the proposed low dimming switch stress LED driver. Copyright © 2015 John Wiley & Sons, Ltd.
Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis
Authors: Mendelson Karen , Lan Yahui , Hla Timothy , Evans Todd 
Published: May 2015

ABSTRACTBackground: The sphingosine 1‐phosphate (S1P) signaling pathway regulates zebrafish cardiogenesis, and provides a paradigm for how signaling gradients coordinate collective cell migration across tissue layers. It is known that the S1P transporter (Spns2) functions in extra‐embryonic YSL to activate G protein–coupled receptor (S1pr2) signaling in endoderm for deposition of positional cues (integrin, fibronectin, etc.). Such cues are recognized by overlying lateral precardiac mesoderm that migrates to the midline and fuses to form the primordial heart tube. However, the source of bio‐active S1P is not known. There are multiple receptors and it is not known if there are earlier or even receptor‐independent functions for S1P. Results: Because S1P can only be generated by sphingosine kinases, we targeted a mutation to the single kinase gene expressed during early embryogenesis (sphk2). Zygotic mutants survive to adulthood and appear normal, but maternal‐zygotic mutant embryos phenocopy null zygotic mutants of spns2 or s1pr2. Conclusions: The data show that maternally derived sphk2 RNA is fully sufficient to generate an S1P signaling gradient in the YSL that ultimately controls precardiac mesoderm migration during embryogenesis. Furthermore, despite maternal expression of sphk2, there are no obvious developmental functions requiring its activity prior to stimulation of S1pr2 in endoderm. Developmental Dynamics 244:948–954, 2015. © 2015 Wiley Periodicals, Inc.
The RVDM: modelling impacts, evolution and competition processes to determine riparian vegetation dynamics
Authors: García‐Arias Alicia , Francés Félix 
Published: May 2015

AbstractThe riparian vegetation dynamic model (RVDM) is an ecohydrological model aimed to study the vegetation dynamics in riparian areas that represents an upgrade with respect to previous tools in the way of understanding the riparian dynamics. Important novelties are proposed by this tool, including a high temporal resolution (daily time step), a proposal of a new plant classification approach useful for research and management (successional plant functional types), good representation of the key processes that determine the vegetation dynamics in riparian areas (drought and flood impacts, recruitment, growth, succession and competition), an easy implementation and feasible inclusion of river morphodynamics in the model implementation (including different daily elevation and soil maps in the inputs). The model implementation in a Mediterranean semi‐arid study site resulted satisfactorily (cell by cell calibration accuracy ≥65% and cell by cell validation accuracy between 40% and 60%), demonstrating the great potential of this approach for future research and management applications. Although 36 parameters are included in the model conceptualization, the global sensitivity analysis demonstrated that only eight types of parameters are actually influent. These parameters are as follows: minimum time since mixed for transition to terrestrial, root depths, transpiration factors, critical shear stress of early stages, minimum biomass required to allow succession, germination minimum capillary water content in the upper soil, effective depth considered for evaporation from bare soil and coverage of pioneers. Riparian vegetation dynamic model will be a useful tool for gaining a better understanding of the riparian plants behaviour under different ecohydrological conditions. Copyright © 2015 John Wiley & Sons, Ltd.
Development of analytical methods for the determination of free and ester bound 2‐, 3‐MCPD, and esterified glycidol in fishery products
Authors: Karl Horst , Merkle Sybille , Kuhlmann Jan , Fritsche Jan 
Published: May 2015

In the present study, existing official methods for oils were modified in order to analyze free and bound MCPD and bound glycidol in fish. Free 3‐MCPD was determined in aqueous extracts of fishery products. DGF standard methods C‐VI‐17(10) and C‐VI‐18(10) and the 3 in 1 method were modified and tested to quantify ester‐bound 2‐ and 3‐MCPD and glycidyl esters. The different methods were validated using spiked fish mince and a naturally contaminated reference material consisting of homogenized smoked sprat and fish sticks. The methods showed good agreement. Assay B of the modified DGF method C‐VI‐18(10) and the adapted 3 in 1 method allow a quantitative determination of bound 2‐ and 3‐MCPD in fishery products. In addition, glycidyl esters can be quantified applying the 3 in 1 method. The screening of various fishery products showed that smoked fish may contain considerable amounts of free 3‐MCPD. Concentrations ranged between 8 and 388 μg/kg wet weight (ww). Only traces of free 3‐MCPD were found in all other fishery products. Fish sticks and fried fish products are potential sources of 3‐ and 2‐MCPD esters, but large variation were observed. Bound 3‐MCPD ranged between 45 and 377 μg/kg ww, bound 2‐MCPD between 9 and 116 μg/kg ww.Practical applications: The European Food Safety Authority (EFSA) is calling for occurrence data of 2‐MCPD, 3‐MCPD, 2‐MCPD ester, 3‐MCPD ester, and glycidyl ester in foods including fishery products. At present, there is no official method for the determination of these food processing contaminants in fish and fishery products. Therefore, the approach of this study was to establish analytical methods for the quantification of free and bound MCPD and bound glycidol in fish, based on the modification of existing methods for edible oils. The adapted methods allow a sensitive quantitative determination of the target analytes in various fishery products.The proposed modified methods allow they analysis of free and bound 2‐, 3‐MCPD, and esterified glycidol in fishery products.
3‐MCPD‐ and glycidyl esters can be mitigated in vegetable oils by use of short path distillation
Authors: Pudel Frank , Benecke Patrick , Vosmann Klaus , Matthäus Bertrand 
Published: May 2015

Short path distillation was applied to produce edible oils low in 3‐MCPD‐FE and G‐FE, but with comparable quality to conventionally deodorized oils. By use of the Response Surface Methology the effect of different process parameters (condenser temperature (X1), evaporator temperature (X2), stirrer speed (X3) and pump frequency (X4)) on quality parameters of the oil (content of 3‐MCPD‐FE/G‐FE (minimal), acid value (minimal), content of vitamin‐E‐active compounds (sum of tocopherols and tocotrienols, maximal) and oxidation stability (maximal)) was investigated. A model was calculated for the production of refined palm oil with lowest amounts of 3‐MCPD‐FE/G‐FE and a chemical and sensory quality comparable to oil produced by standard deodorization. For the different variables of short path distillation no 3‐MCPD‐FE was detected in any of the samples, while the level for G‐FE ranged between the limit of detection and 0.7 mg/kg. A target conflict between the content of vitamin‐E‐active compounds (maximal) and acid value (minimal) was found, but in a (global) optimum of all target quality parameters (condenser temperature = 60°C, evaporator temperature = 170°C, stirrer speed = 100 rpm and pump frequency = 20 Hz) the quality of the short path distilled palm oil was comparable to conventionally refined palm oil. Slightly poorer sensory quality regarding taste and smell can be improved by a mild deodorization after short path distillation. Only the colour of the resulting oil differs from that of a conventionally refined oil, one being orange red due to the carotinoids which were not thermally decomposed.Practical Application: Mitigation of 3‐MCPD‐FE and G‐FE is a big issue in oil processing. Especially for sensible products such as baby food the content of the esters should be as low as possible without changing the quality of the edible oil. Short path distillation is known as a gentle method used for the enrichment and purification of heat‐sensitive compounds. Thus the application of short path distillation on the purification of edible oils within the refining process could be an interesting option for the production of oils low in 3‐MCPD and glycidyl esters while maintaining high oil quality.Use of Response Surface Methology short path distillation followed by mild deodorization (180°C, 120 min) has been optimized to obtain edible oils low in 3‐MCPD‐FE and G‐FE but with comparable oil quality to conventionally deodorization. Only the red colour of palm oil was not reduced by this procedure.
Gold‐ and Silver‐Catalyzed 7‐endo‐dig Cyclizations for the Synthesis of Oxazepines
Authors: Peshkov Anatoly A. , Nechaev Anton A. , Pereshivko Olga P. , Goeman Jan L. , Van der Eycken Johan , Peshkov Vsevolod A. , Van der Eycken Erik V. 
Published: May 2015

AbstractA comprehensive study on gold‐ and silver‐catalyzed cycloisomerizations of hydroxypropargylamides into oxazepines is described. Three different types of hydroxypropargylamide substrates derived from either amide coupling or Ugi reactions have been validated resulting in establishment of selective and general access to a medium‐ring oxazepine core.
Capillary electrophoresis coupled to contactless conductivity detection for the analysis of S‐nitrosothiols decomposition and reactivity
Authors: Ismail Abdulghani , d'Orlyé Fanny , Griveau Sophie , Bedioui Fethi , Varenne Anne , da Silva José Alberto Fracassi 
Published: May 2015

S‐Nitrosothiols (RSNO) are composed of a NO group bound to the sulfhydryl group of a peptide or protein. RSNO are very important biological molecules, since they have many effects on human health. RSNO are easily naturally decomposed by metal ions, light, and heat, with different kinetics. They can furthermore undergo transnitrosation (NO moieties exchange), which is a crucial point in physiological conditions since the concentration ratios between the different nitrosothiols is a key factor in many physiopathological processes. There is therefore a great need for their quantitation. Many S‐nitrosothiol detection and quantitation methods need their previous decomposition, leading thus to some limitations. We propose a direct quantitation method employing the coupling of capillary electrophoresis with a homemade capacitively coupled contactless conductivity (C4D) detector in order to separate and quantify S‐nitrosoglutathione and its decomposition products. After optimization of the method, we have studied the kinetics of decomposition using light and heat. Our results show that the decomposition by light is first order (kobs = (3.40 ± 0.15) × 10−3 s−1) while that using heat (at 80°C) is zeroth order (kobs,80°C = (4.34 ± 0.14) × 10−6 mol L−1 s−1). Transnitrosation reaction between S‐nitrosoglutathione and cysteine was also studied, showing the possibility of separation and detection of all the products of this reaction in less than 2.5 min.
iGWAS: Integrative Genome‐Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis
Authors: Huang Yen‐Tsung , Liang Liming , Moffatt Miriam F. , Cookson William O. C. M. , Lin Xihong 
Published: May 2015

ABSTRACTGenome‐wide association studies (GWAS) have been a standard practice in identifying single nucleotide polymorphisms (SNPs) for disease susceptibility. We propose a new approach, termed integrative GWAS (iGWAS) that exploits the information of gene expressions to investigate the mechanisms of the association of SNPs with a disease phenotype, and to incorporate the family‐based design for genetic association studies. Specifically, the relations among SNPs, gene expression, and disease are modeled within the mediation analysis framework, which allows us to disentangle the genetic effect on a disease phenotype into two parts: an effect mediated through a gene expression (mediation effect, ME) and an effect through other biological mechanisms or environment‐mediated mechanisms (alternative effect, AE). We develop omnibus tests for the ME and AE that are robust to underlying true disease models. Numerical studies show that the iGWAS approach is able to facilitate discovering genetic association mechanisms, and outperforms the SNP‐only method for testing genetic associations. We conduct a family‐based iGWAS of childhood asthma that integrates genetic and genomic data. The iGWAS approach identifies six novel susceptibility genes (MANEA,MRPL53,LYCAT,ST8SIA4,NDFIP1, andPTCH1) using the omnibus test with false discovery rate less than 1%, whereas no gene using SNP‐only analyses survives with the same cut‐off. The iGWAS analyses further characterize that genetic effects of these genes are mostly mediated through their gene expressions. In summary, the iGWAS approach provides a new analytic framework to investigate the mechanism of genetic etiology, and identifies novel susceptibility genes of childhood asthma that were biologically meaningful.
Late Triassic aetosaur (Archosauria) from Krasiejów (SW Poland): new species or an example of individual variation?
Authors: Antczak Mateusz 
Published: May 2015

AbstractAn aetosaur discovery in Krasiejów (SW Poland), in Late Triassic deposits, was first described by Sulej in 2010 as a new species carrying the name Stagonolepis olenkae. However, new fossil material suggests that its taxonomical position is not as clear as was initially presumed. In the new material from the ‘Triassic’ site of Krasiejów, the typical features of Stagonolepis robertsoni, described by Walker in 1961 from the Elgin area of Scotland, were identified (i.e. frontal/prefrontal width ratio), as well as features of S. olenkae (i.e. angle between ventral edge of the maxilla and ventral edge of the antorbital fenestra). However, distinct features from both species, such as the shape of the canal at the dorsal surface of the frontal, are present. Some of the variation is similar to sexual dimorphism observed in recent amphibians and reptiles. These variations, as well as the fact that the postcranial skeleton was previously described as S. robertsoni by Lucas and co‐workers in 2007, suggest that the taxonomical affiliation of the Krasiejów aetosaur (and/or the number of aetosaur species) should be re‐considered. Copyright © 2015 John Wiley & Sons, Ltd.