bluuebunny/crossref_metadata_2025_split huggingface dataset:
ET-A receptor antagonist BQ123 prevents radiocontrast media-induced renal medullary hypoxia
Authors: Liss P. , Carlsson P.-O. , Nygren A. , Palm F. , Hansell P. 
Published: September 2013

Purpose: Renal vasoconstriction with resultant tissue hypoxia, especially in the renal medulla, has been suggested to play a role in contrast media (CM)-induced nephropathy. Endothelin (ET) is released into the blood stream following CM injection and has been proposed as a potential mediator through its vasoconstrictive properties. Material and Methods: To investigate the possible protective influence of ET-receptor antagonists against CM-induced reduction in renal function, we studied the effects of injection of iopromide with and without pretreatment with BQ123 (ET-A antagonist) or BQ788 (ET-B antagonist) on renal superficial cortical flow (CBF), outer medullary blood flow (OMBF) and outer medullary oxygen tension (pO2) in normal rats. Results: Administration of CM (1600 mg I/kg b.w.) did not affect CBF in any of the groups. However, a transient decrease in OMBF occurred, which was unaffected by both BQ123 and BQ788. Also a transient decrease in outer medullary pO2 was induced by CM administration. The pO2 reduction was significantly smaller after pretreatment with BQ123, than after injection of CM alone or together with BQ788, and pO2 returned more rapidly to the control level. Neither receptor antagonist had an effect on CM-mediated increases in electrolyte excretion. Conclusion: In the normal rat, activation of ET-A receptors is partly involved in the depression of outer medullary pO2 caused by injection of iopromide. However, the decrease in OMBF after iopromide injection is not mediated by ET receptors. The beneficial effects of the ET-A receptor antagonist on CM-induced changes in outer medullary pO2 seem therefore not primarily mediated on the hemodynamic level but may rather involve tubular transport mechanisms.
Comparison of 99mTc-Sestamibi scintimammography and dynamic MR imaging as adjuncts to mammography in the diagnosis of breast cancer
Authors: Boné B. , Kristoffersen Wiberg M. , Szabó B. K. , Szakos A. , Danielsson R. 
Published: September 2013

Purpose: To compare the diagnostic accuracy of planar 99mTc-sestamibi scintimammography with dynamic contrast-enhanced MRI (CE-MRI) on the basis of histopathologic results, and to determine the clinical value of these methods as adjuncts to mammography. Material and Methods: A total of 90 consecutive women with 111 histopathologically verified breast lesions were enrolled in the study. Patients underwent scintimammography and CE-MRI in addition to mammography. Each finding was classified on a BI-RADS-like five-point rating scale describing the degree of suspicion for malignancy, and all findings were correlated with the histopathological results. Results: The overall sensitivity/specificity/accuracy was 85%/59%/78% for mammography, 94%/47%/80% for CE-MRI, and 82%/75%/80% for scintimammography, respectively. CE-MRI showed higher sensitivity ( p = 0.008), but its specificity was lower than scintimammography ( p = 0.049). Using ROC analysis, significant improvement ( p = 0.034) was found between mammography and the combination of mammography + CE-MRI, while mammography + scintigraphy showed no higher diagnostic accuracy than mammography alone. Conclusion: If high sensitivity and spatial resolution are needed, CE-MRI is to be preferred in clinical practice as an adjunct to mammography, rather than scintigraphy.
Spatial component position in total hip arthroplasty: Accuracy and repeatability with a new CT method
Authors: Olivecrona H. , Weidenhielm L. , Olivecrona L. , Noz M. E. , Maguire G. Q. , Zeleznik M. P. , Svensson L. , Jonson T. 
Published: September 2013

Purpose: 3D detection of centerpoints of prosthetic cup and head after total hip arthroplasty (THA) using CT. Material and Methods: Two CT examinations, 10 min apart, were obtained from each of 10 patients after THA. Two independent examiners placed landmarks in images of the prosthetic cup and head. All landmarking was repeated after 1 week. Centerpoints were calculated and compared. Results: Within volumes, all measurements of centerpoints of cup and head fell, with a 95% confidence, within one CT-voxel of any other measurement of the same object. Across two volumes, the mean error of distance between center of cup and prosthetic head was 1.4 mm (SD 0.73). Intra- and interobserver 95% accuracy limit was below 2 mm within and below 3 mm across volumes. No difference between intra- and interobserver measurements occurred. A formula for converting finite sets of point landmarks in the radiolucent tread of the cup to a centerpoint was stable. The percent difference of the landmark distances from a calculated spherical surface was within one CT-voxel. This data was normally distributed and not dependent on observer or trial. Conclusion: The true 3D position of the centers of cup and prosthetic head can be detected using CT. Spatial relationship between the components can be analyzed visually and numerically.
Increased progression of carotid intima media thickness in thyroid peroxidase antibodies-positive rheumatoid arthritis patients
Authors: Raterman H G , Voskuyl A E , Simsek S , Schreurs M W J , van Hoogstraten I M W , Peters M J L , van Halm V P , Dijkmans B A C , Lips P , Lems W F , Nurmohamed M T 
Published: September 2013

ObjectiveAutoimmune diseases such as rheumatoid arthritis (RA) and hypothyroidism tend to cluster, and this coexistence amplifies the elevated cardiovascular risk in RA. Whether thyroid peroxidase antibodies (TPOabs) are associated with increased cardiovascular disease (CVD) risk has not been studied extensively. Therefore, this study determined firstly the prevalence of TPOabs in RA and secondly whether TPOabs were associated with CVD. Moreover, this study explored whether TPOabs were related to RA characteristics.Design and methodsData from the CARRÉ Study, an ongoing study investigating CVDs and its risk factors in RA (n=322), was used to ascertain the prevalence of TPOabs in RA patients. In addition, cardiovascular and RA disease characteristics were compared between TPOabs-positive and -negative patients at baseline and at a second visit after 3 years.ResultsTPOabs were present in 47/322 (15%) RA patients and TSH levels were higher in TPOabs-positive patients (1.40 mU/l) compared with TPOabs-negative patients (1.26 mU/l, P=0.048). At baseline and after 3 years no association was observed between TPOabs and (risk factors for) CVD. Regression analyses revealed a significantly larger progression of carotid intima media thickness (cIMT; β=0.13 mm) in TPOabs-positive compared with TPOabs-negative patients independent of risk factors for cIMT progression. RA disease activity scores (DAS28) were higher in TPOabs-positive compared with TPOabs-negative patients (4.4 vs 3.8 P=0.018).ConclusionsTPOabs were associated with increased cIMT progression. Moreover, an association between TPOabs and DAS28 was observed. Hence, TPOabs seems to have a role in the amplified cardiovascular risk in RA patients.
Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1
Authors: Åberg N David , Olsson Sandra , Åberg Daniel , Jood Katarina , Stanne Tara M , Nilsson Michael , Blomstrand Christian , Svensson Johan , Isgaard Jörgen , Jern Christina 
Published: September 2013

ObjectiveIn humans, serum IGF1 (s-IGF1) is associated with outcome after ischemic stroke (IS). Therefore variation at the IGF1 locus could also associate with both IS and s-IGF1. We investigated whether genetic variation at the IGF1 locus is associated with i) s-IGF1, ii) IS occurrence, iii) IS severity, and iv) post-stroke outcome.Design/methodsPatients (n=844; 66% males, mean age 56 years) and community controls (n=668) were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). Post-stroke outcome was evaluated with the modified Rankin Scale at 3 and 24 months after index stroke, and baseline stroke severity with the Scandinavian Stroke Scale. s-IGF1 was determined in patients and after random selection in 40 of the controls.ResultsEleven single nucleotide polymorphisms (SNPs) were selected in the IGF1 gene. In healthy controls the major allele of rs7136446 was associated with higher s-IGF1, whereas in patients no such association was found. No SNP was associated with IS, nor with stroke severity. After multivariate correction for presence of diabetes, smoking, and hypertension, the major allele of rs7136446 was associated with favorable functional outcome 24-months post-stroke (odds ratio 1.46; 95% CI 1.09–1.96).ConclusionVariation in rs7136446 of the IGF1 gene associates with post-stroke outcome in relatively young IS patients. Also, rs7136446 associates with s-IGF1 in controls but not in IS, which indicates that IS perturbs a normal genetic impact on s-IGF1 levels.
Selected Composites for High Field Magnets
Authors: Han Ke , Chen Jingping , Cui Baozhi , Davy Charney A , Kalu Peter N 
Published: September 2013

AbstractThe national high magnetic field laboratory builds and uses various high field magnets for fundamental research. In building high field magnets, a variety of high strength composites are required because of the Lorentz stresses generated by high field exceeding the strength of most of the materials, particular conductors. For example, a field of 60 T can generate a magnetic pressure that corresponds to a stress in the conductor of 1.5 GPa, which is at the limit of known conducting materials with conductivity higher than 70% International Annealed Copper Standard and sizes suitable for building high field magnets. The design of high field magnets is limited by these forces and, consequently, by the available materials. At the same time, the materials need to have excellent physical properties. For instance, the conductors need to have high electrical conductivity and high specific heat and the superconductors should have high critical current in field and low alternative current losses. This paper outlines our requirements and research on metal matrix composite materials for building high field magnets. The discussions include both the macrocomposite and microcomposite. The scales of the structures in the composites are from millimeters to nanometers.
The Incidence and Risk of Inducing Hyperthyroidism Following Amiodarone Treatment
Authors: Cozlea D L , Farcas D M , Keresztesi A A , Silivastru I , Cozlea L , Carașca E 
Published: September 2013

Abstract
Introduction: Amiodarone, a frequently used antiarrhythmic drug in cardiology, is very efficient in the treatment of ventricular and supraventricular tachiarrithmyas. The iodine content of amiodarone is 39%. Its chemical structure is similar to tyrosine. It is estimated that 1-23% of patients treated with amiodarone can develop hyperthyroidism. The purpose of this study is to assess and monitor the incidence of hyperthyroidism induced by amiodarone in patients admitted for various types of cardiac dysrhythmias, considering that most of the patients included in the study came from an endemic goitre area.

Material and method: One-hundred patients chosen systematically (62 men, 38 women) from 560 patients treated with amiodarone in the January 1st, 2009 - December 31, 2009 period were assessed (clinically, laboratory findings and imaging studies); their mean age was 64 years (range 50-70 years). In order to identify and diagnose hyperthyroidism, a questionnaire (Newcastle index) was used, also urinary iodine dosage, hormonal dosages (T3, T4, TSH) and thyroid imaging (ultrasound, radioactive iodine uptake test) were used.

Results: The incidence of hyperthyroidism induced by amiodarone in this study was 8%. Hyperthyroidism was more frequent in women (6 women vs. 2 men).

Conclusions: Thyroid hormonal levels have to be determined and a clinical or thyroid ultrasound examination should be made prior to initiating a treatment with amiodarone. At the end of the study, 8 patients, most of them female, were diagnosed with hyperthyroidism.
The Therapeutic Management Of Retroperitoneal Injuries
Authors: Crăciun C , Azamfirei L , Coroș M F , Hintea A , Cozma D , Sorlea S , Dobre A 
Published: September 2013

Abstract
Background: In the retro peritoneum different organs of various origins (vascular, nervous, muscular, fascia, etc.) are located. These represent the source of different surgical conditions that cause, even today, serious problems of early diagnosis and treatment.

Material and method: We have conducted a retrospective study throughout a period of 8 years (2004-2011). We followed the incidence, the treatment and the evolution of several types of retroperitoneal lesions.

Results: In this period 79 cases of retroperitoneal conditions were encountered, representing 0.51% from the total of 15,284 patients admitted and treated within our clinic. The most common cases were those of tumour conditions and retroperitoneal primitive tumours (RPT). Many inflammatory conditions were also encountered. There were a few cases of retroperitoneal overflows or of parasitic diseases and we did not encounter cases of retroperitoneal fibrosis or malacoplaky.

Conclusions: In our study the majority of the retroperitoneal conditions were of tumour nature, especially malignant RPTs. Secondary retroperitoneal tumours (adenopathies, metastases, relapses) were less frequent. The excision of the retroperitoneal tumours is delicate, especially due to the vascular factor caused by anatomical conditions and their own vascularisation. On well-chosen cases we can use minimally invasive surgical techniques (laparoscope, punctures and eco-guided drainages), which enable a favorable post-operative evolution.
A Retrospective Longitudinal Study Regarding The Dental Anomalies Of Position With Eruptive Etiology
Authors: (Nagy-Bota) Muica Monica-Cristina , Păcurar Mariana , (Chibelean) Cireș-Marginean Manuela , Jurcă Anamaria , (Coșarcă) Lup Adina Simona , A Tudor 
Published: September 2013

Abstract
Objective: Given the high frequency of dental anomalies of position and the lack of preventive measures of surveillance and monitoring of the eruption of permanent teeth, the aim of this study is to evaluate the frequency of dental anomalies of position in children.

Material and methods: We conducted a retrospective longitudinal study in the 2006-2012 period. Data were collected from the medical records and orthopantomography x-rays of 408 patients (230 female and 178 male) who presented to the Pedodontics-Orthodontics Clinic in Tîrgu Mureș. After applying the exclusion criteria, 77 patients remained in the study.

Results: From the 77 patients, 57 had dental inclusions, 15 presented ectopic teeth, dental rotations have been observed in 2 patients, and midline diastema in 5 patients. Regarding sex distribution, there was a higher frequency of dental inclusions in women (39) than men (38). The frequency of dental inclusions, regarding dental groups, in a descending order was: maxillary canine, mandibular second premolar, mandibular canine, maxillary second premolar, mandibular first premolar, maxillary first premolar, maxillary lateral incisor, maxillary central incisor and maxillary and mandibular first molars. The frequency of dental inclusions in the dental support area had the highest rate in the 12-14 years age group.

Conclusions: From all the studied dental anomalies, dental inclusions presented the highest frequency. Regarding the dental support area, most cases of dental inclusion were observed in the 12-14 years age group.
Tattoo-Associated Skin Reactions — Clinical Cases
Authors: Fekete GyL , Fekete Júlia Edit 
Published: September 2013

Abstract
Tatooing has been practiced for thousands of years. It has become a common practice for people of Western countries in the last 10-20 years, where approximately 3-5% of the population has at least one tattoo. Various pigmented substances introduced into the skin may cause the occurrence of adverse irritative, immunological, infectious or other reactions of the skin. We present three clinical cases with adverse reactions after tattooing.
Communicating Hope In The Real World
Authors: Atkins Andy 
Published: September 2013

Abstract
This paper outlines a methodology for campaigning on environmental issues at a time when hope is in short supply. Brief consideration is given to the real world context. Current environmental concerns are set within the present economic downturn. Our science is generally much better, and many more players are interested in the environment. There has been a media revolution in the last 10 years, and there are now many more ways of communicating information. The equation ‘Proposal + People + Opportunity = Change’ is explored. The principles elucidated are applied to a case study of ‘The Bee Cause’, a Friends of the Earth campaign. The implications for Christian leaders are then investigated
The Rise In Popularity Of The Lithuanian Political Party Drasos Kelias
Authors: Mažylis Liudas , Unikaitė-Jakuntavičienė Ingrida , Ivanovas Bernaras 
Published: September 2013

ABSTRACT
This article examines the genesis of a new Lithuanian political unit, the Drasos kelias party, which was created in 2012 and successfully participated in the 2012 Lithuanian parliamentary elections, reconstructing it in three stages based on the analysis of news portals. Reconstruction of the first stage is based on the competing “conspiracy versions” (two different interpretations of the unsolved criminal story in the news media) in 2009- 2010. Two archetypal characters (criminal and/or hero) were sought in the interpretation of the two aforementioned versions. Agenda setting and media framing theories were used as explanatory theories. The second stage (2011-2012) is reconstructed through further analysis of the news portals as well as through the analysis of some additional research from the interviews and focus group discussions. This data allowed us to retrace the logic of collective thinking. This logic of collective thinking contributed to the formation of a continuous “single issue” protest community which was united by the slogan “do not hand the child to a paedophilia clan”. This group of people constantly hindered the governmental institutions from the implementation of the court decision to hand the child to her mother, and over a long period of time its protest arguments expanded from “not handing the child to her mother” to protests against the entire Lithuanian legal system. Further, the third stage associated with formal institutionalization of political party and its rising of popularity among the voters in the 2012 Lithuanian parliamentary elections is analyzed. The analysis stresses the importance of social and personal networks for the regional dispersion of party election results.
The Use Of Alternative Measures In The Czech Republic
Authors: Ščerba Filip 
Published: September 2013

ABSTRACT
This article deals with Czech legal regulation of alternative measures and their use in practice within the Czech criminal justice system. Attention is focused on procedural alternative measures, i.e. diversions in criminal proceedings, as well as on alternative punishments. The development of Czech criminal law has been strongly influenced by the conception of restorative justice, which was the base for the effort to spread the scope of alternative measures and to reduce the number of the imprisoned. But the introduction of new measures (diversions, community service, house arrest, etc.) was accompanied by some problems regarding their use in practice; some of them were connected with legal regulation, other ones were caused by incorrect use. The article identifies these problems (also through analysis of statistical data) and also describes solutions to the problems.
Efficience of Cardiopulmonary Resuscitation in Emergency Medical Service and University Hospital
Authors: Kaleja Anita , Snucina Elina , Vanags Indulis 
Published: September 2013

Summary
Introduction.Survival rate among patients with cardiac arrest remains unclear. Return of spontaneous circulation (ROSC) is just the first step toward the goal of complete recovery from cardiac arrest. It depends on quality of cardiopulmonary resuscitation (CPR) during resuscitation and factors of postresuscitation care. Regular CPR analysis has not been carried out in Latvia.
Aim of the study was to evaluate survival rate among patients with out-of-hospital cardiac arrest and in-hospital cardiac arrest.
Materials and methods. The study was conducted in the State Emergency service of Latvia and Pauls Stradins Clinical University Hospital during 15 months in 2010/2011. There were 221 adult patients with in-hospital cardiac arrest and 162 adult patients with out-of-hospital cardiac arrest and performed CPR included in retrospective research. The information was analyzed by medical records. The obtained results were expressed in percents and compared, using the Pearson’s Chi-square (Pearson χ2) test.
Results. The short-term ROSC was achieved among patients with out-of-hospital cardiac arrest (OHCA) in 62 cases and among patients with in-hospital cardiac arrest (IHCA) in 186 cases. Survival to discharge was achieved in 20.3% among patients with OHCA and 15.8% among patients with IHCA. The most commonly used CPR algorithm was pulseless electrical activity/asystole (72 - 73%). Short-term ROSC was achieved most frequently by ventricular fibrillation/pulseless ventricular tachycardia (41.3-56%), but the largest number of unsuccessful CPR episodes was observed by pulseless electrical activity/ asystole.
Conclusion. Results of CPR were different among patients with OHCA and IHCA. ROSC is rhythm-specific outcome.
Application of Novel Methods for Non-Small Cell Lung Cancer (Nsclc) Biomarker Discovery
Authors: Spaks Artjoms , Pirtnieks Ainis , Grusina-Ujumaza Jelena , Basko Jazeps , Krievins Dainis 
Published: September 2013

Summary
Introduction. Research in NSCLC biomarker field and application of new methods is essential as it is promising strategy to reduce cancer mortality.
Aim of the study. The aim of the study was to develop new approach for lung cancer biomarker research and introduce novel method into surgical practice, verifying method’s safety and evaluate intraoperative and postoperative complications.
Materials and methods. 50 patients with early stage NSCLC undergoing lobectomy were randomized into two groups - experimental (n = 25) and control group (n = 25). In experimental group at the time of thoracotomy and resection of the lung, paired blood samples were obtained from the lobar pulmonary vein draining lung segment containing tumor and from the peripheral vein which represents the systemic circulation. Safety of the procedure and its influence on surgery was evaluated.
Results. New approach for lung cancer biomarker research was developed. Injuries of major anatomical structures as pulmonary blood vessels, bronchi, trachea and pericardium due to blood sample collection were not observed. There was no difference in hospital stay and chest tube drainage duration. There were no perioperative deaths in both groups. Morbidity rate in experimental group was similar to control group.
Conclusions. Application of new method for developing multimodal lung cancer model is safe and does not increase the risk of intraoperative and postoperative complications.