bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of caregivers’ vaccination intention with respect to child age group: a cross-sectional survey in South Korea
Authors: Paek Hye-Jin , Shin Kyung-Ah , Park Kisoo 
Published: September 2015

ObjectiveThis study examined how knowledge, risk perception, health beliefs and multidimensional health locus of control (HLC) were associated with caregivers’ intention to vaccinate their child, and how these associations varied across child age groups.SettingSouth Korea.MethodsThe cross-sectional survey was conducted via a face-to-face interview among 1017 nationally representative caregivers who had children aged 12 or younger. The outcome variable was caregivers’ intention to vaccinate their children.ResultsHierarchical regression analysis indicated that risk perception was negatively associated with vaccination intention only among the age group 4–6 (β=−0.127, p<0.05). Perceived benefit was the only significant predictor of the outcome variables for all three age groups. In contrast, perceived barrier was negatively related to vaccination intention only among the age group 7–12 (β=−0.104, p<0.05). Internal HLC was positively related to vaccination intention only among the age group 7–12 (β=0.151, p<0.001), while chance HLC was negatively related to vaccination intention only among the age group 0–3 (β=−0.121, p<0.05).ConclusionsThis study identifies key vaccination intention determinants that are differentially associated with caregivers’ children's age groups. To improve vaccination rates, it suggests the need for strategies tailored to children's age.
Prevalence of multimorbidity in the adult population attending primary care in Portugal: a cross-sectional study
Authors: Prazeres Filipe , Santiago Luiz 
Published: September 2015

ObjectivesTo determine the prevalence of multimorbidity in the adult population attending primary care in Portugal, to identify associated sociodemographic factors, and to reveal combinations of chronic health problems.DesignCross-sectional, analytical study.SettingPrimary Care Centres in mainland Portugal across the five Portuguese Healthcare Administrative Regions.Participants1279 women and 714 men agreed to participate. The mean age was 56.3 years (59.0 years for men; 54.8 years for women). The most frequent marital status was married/cohabiting (69.5%). The most predominant living arrangement was living as a couple (57.2%). A considerable proportion consisted of pensioners/retirees (41.5%) and adults with a low educational level (48.7%). Sufficient monthly income was reported in 54.4% of the cases.Primary outcome measuresFor each patient, multimorbidity was measured either by the presence of ≥2 or ≥3 chronic health problems, from a list of 147 chronic health problems. Clinical data were collected using the general practitioner's knowledge of the patient's history, patient's self-report and medical records. Cluster analyses were performed to reveal distinct patterns of multimorbidity.Secondary outcome measuresPatient social and demographic data (sex, age, residence area, current marital status, number of years of formal education, living arrangements, professional status and self-perceived economic status). Logistic regression analyses were performed to determine the association between sociodemographic factors and multimorbidity.ResultsMultimorbidity (2 or more chronic health problems) was present in 72.7%. When a cut-off of three or more was used, an expressive percentage of multimorbidity (57.2%) remained present. The likelihood of having multimorbidity increased significantly with age. Pensioners/retirees and adults with low levels of education were significantly more likely to suffer from multimorbidity. Cardiometabolic and mental disorders were the most common chronic health problems. Six multimorbidity clusters have been identified.ConclusionsMultimorbidity was found to be a common occurrence in the Portuguese primary care users. Future primary healthcare policies should take multimorbidity into consideration.
One size fits all? Mixed methods evaluation of the impact of 100% single-room accommodation on staff and patient experience, safety and costs
Authors: Maben Jill , Griffiths Peter , Penfold Clarissa , Simon Michael , Anderson Janet E , Robert Glenn , Pizzo Elena , Hughes Jane , Murrells Trevor , Barlow James 
Published: September 2015

Background and objectivesThere is little strong evidence relating to the impact of single-room accommodation on healthcare quality and safety. We explore the impact of all single rooms on staff and patient experience; safety outcomes; and costs.MethodsMixed methods pre/post ‘move’ comparison within four nested case study wards in a single acute hospital with 100% single rooms; quasi-experimental before-and-after study with two control hospitals; analysis of capital and operational costs associated with single rooms.ResultsTwo-thirds of patients expressed a preference for single rooms with comfort and control outweighing any disadvantages (sense of isolation) felt by some. Patients appreciated privacy, confidentiality and flexibility for visitors afforded by single rooms. Staff perceived improvements (patient comfort and confidentiality), but single rooms were worse for visibility, surveillance, teamwork, monitoring and keeping patients safe. Staff walking distances increased significantly post move. A temporary increase of falls and medication errors in one ward was likely to be associated with the need to adjust work patterns rather than associated with single rooms per se. We found no evidence that single rooms reduced infection rates. Building an all single-room hospital can cost 5% more with higher housekeeping and cleaning costs but the difference is marginal over time.ConclusionsStaff needed to adapt their working practices significantly and felt unprepared for new ways of working with potentially significant implications for the nature of teamwork in the longer term. Staff preference remained for a mix of single rooms and bays. Patients preferred single rooms.
Inactivation of the p53–KLF4–CEBPA Axis in Acute Myeloid Leukemia
Authors: Seipel Katja , Marques Miguel Teixera , Bozzini Marie-Ange , Meinken Christina , Mueller Beatrice U. , Pabst Thomas 
Published: September 2015

Abstract
Purpose: In acute myeloid leukemia (AML), the transcription factors CEBPA and KLF4 as well as the universal tumor suppressor p53 are frequently deregulated. Here, we investigated the extent of dysregulation, the molecular interactions, and the mechanisms involved.
Experimental Design: One hundred ten AML patient samples were analyzed for protein levels of CEBPA, KLF4, p53, and p53 modulators. Regulation of CEBPA gene expression by KLF4 and p53 or by chemical p53 activators was characterized in AML cell lines.
Results: We found that CEBPA gene transcription can be directly activated by p53 and KLF4, suggesting a p53–KLF4–CEBPA axis. In AML patient cells, we observed a prominent loss of p53 function and concomitant reduction of KLF4 and CEBPA protein levels. Assessment of cellular p53 modulator proteins indicated that p53 inactivation in leukemic cells correlated with elevated levels of the nuclear export protein XPO1/CRM1 and increase of the p53 inhibitors MDM2 and CUL9/PARC in the cytoplasm. Finally, restoring p53 function following treatment with cytotoxic chemotherapy compounds and p53 restoring non-genotoxic agents induced CEBPA gene expression, myeloid differentiation, and cell-cycle arrest in AML cells.
Conclusions: The p53–KLF4–CEBPA axis is deregulated in AML but can be functionally restored by conventional chemotherapy and novel p53 activating treatments. Clin Cancer Res; 22(3); 746–56. ©2015 AACR.
Unconjugated Bilirubin Is a Novel Prognostic Biomarker for Nasopharyngeal Carcinoma and Inhibits Its Metastasis via Antioxidation Activity
Authors: Deng Cheng-Cheng , Xu Miao , Li Jing , Luo Xiao-Lin , Zhu Yu-Jia , Jiang Rou , Zhang Meng-Xia , Lei Jin-Ju , Lian Yi-Fan , Zou Xiong , You Rui , Chen Li-Zhen , Feng Qi-Sheng , Bei Jin-Xin , Chen Ming-Yuan , Zeng Yi-Xin 
Published: September 2015

AbstractDistant metastasis is the most common cause of treatment failure and mortality in nasopharyngeal carcinoma (NPC) patients. Thus, it is important to understand the mechanism of NPC metastasis and identify reliable prognostic factors. In this study, we investigated the prognostic value of unconjugated bilirubin (UCB), which was previously considered a byproduct of heme catabolism, in NPC patients and examined the effects of UCB on NPC metastasis. The receiver operating characteristic analysis–generated UCB cutoff point for DMFS was 9.7 μmol/L. We found that higher UCB levels were significantly associated with favorable distant metastasis-free survival (DMFS, 93.3% vs. 84.2%, P &lt; 0.001) in NPC patients and was an independent predictor for DMFS (HR, 0.416; 95% confidence interval, 0.280–0.618; P &lt; 0.001). We next found that UCB treatment impaired the invasion capability of NPC cells and potently inhibited lung metastasis of NPC cells in nude mice. Further investigation showed that UCB inhibited reactive oxygen species production, which is involved in the repression of ERK1/2 activation and matrix metalloproteinase-2 (MMP-2) expression. Moreover, lower levels of ERK1/2 phosphorylation and MMP-2 expression were observed in the NPC lung metastases of nude mice administered UCB. Taken together, our results indicate that UCB is a significantly favorable factor for DMFS in NPC patients and may play an important role in NPC chemoprevention. Cancer Prev Res; 9(2); 180–8. ©2015 AACR.
Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result ofPax5-Inherited Susceptibility
Authors: Martín-Lorenzo Alberto , Hauer Julia , Vicente-Dueñas Carolina , Auer Franziska , González-Herrero Inés , García-Ramírez Idoia , Ginzel Sebastian , Thiele Ralf , Constantinescu Stefan N. , Bartenhagen Christoph , Dugas Martin , Gombert Michael , Schäfer Daniel , Blanco Oscar , Mayado Andrea , Orfao Alberto , Alonso-López Diego , Rivas Javier De Las , Cobaleda César , García-Cenador Maria Begoña , García-Criado Francisco Javier , Sánchez-García Isidro , Borkhardt Arndt 
Published: September 2015

AbstractEarlier in the past century, infections were regarded as the most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However, there is a lack of relevant biologic evidence supporting this hypothesis. We present in vivo genetic evidence mechanistically connecting inherited susceptibility to pB-ALL and postnatal infections by showing that pB-ALL was initiated in Pax5 heterozygous mice only when they were exposed to common pathogens. Strikingly, these murine pB-ALLs closely resemble the human disease. Tumor exome sequencing revealed activating somatic, nonsynonymous mutations of Jak3 as a second hit. Transplantation experiments and deep sequencing suggest that inactivating mutations in Pax5 promote leukemogenesis by creating an aberrant progenitor compartment that is susceptible to malignant transformation through accumulation of secondary Jak3 mutations. Thus, treatment of Pax5+/− leukemic cells with specific JAK1/3 inhibitors resulted in increased apoptosis. These results uncover the causal role of infection in pB-ALL development.Significance: These results demonstrate that delayed infection exposure is a causal factor in pB-ALL. Therefore, these findings have critical implications for the understanding of the pathogenesis of leukemia and for the development of novel therapies for this disease. Cancer Discov; 5(12); 1328–43. ©2015 AACR.See related commentary by Greaves and Müschen, p. 1244.This article is highlighted in the In This Issue feature, p. 1225
Comparison of the Short-Term Risk of Bleeding and Arterial Thromboembolic Events in Nonvalvular Atrial Fibrillation Patients Newly Treated With Dabigatran or Rivaroxaban Versus Vitamin K Antagonists
Authors: Maura Géric , Blotière Pierre-Olivier , Bouillon Kim , Billionnet Cécile , Ricordeau Philippe , Alla François , Zureik Mahmoud 
Published: September 2015

Background—
The safety and effectiveness of non–vitamin K antagonist (VKA) oral anticoagulants, dabigatran or rivaroxaban, were compared with VKA in anticoagulant-naive patients with nonvalvular atrial fibrillation during the early phase of anticoagulant therapy.

Methods and Results—
With the use of the French medico-administrative databases (SNIIRAM and PMSI), this nationwide cohort study included patients with nonvalvular atrial fibrillation who initiated dabigatran or rivaroxaban between July and November 2012 or VKA between July and November 2011. Patients presenting a contraindication to oral anticoagulants were excluded. Dabigatran and rivaroxaban new users were matched to VKA new users by the use of 1:2 matching on the propensity score. Patients were followed for up to 90 days until outcome, death, loss to follow-up, or December 31 of the inclusion year. Hazard ratios of hospitalizations for bleeding and arterial thromboembolic events were estimated in an intent-to-treat analysis using Cox regression models. The population was composed of 19 713 VKA, 8443 dabigatran, and 4651 rivaroxaban new users. All dabigatran- and rivaroxaban-treated patients were matched to 16 014 and 9301 VKA-treated patients, respectively. Among dabigatran-, rivaroxaban-, and their VKA-matched–treated patients, 55 and 122 and 31 and 68 bleeding events and 33 and 58 and 12 and 28 arterial thromboembolic events were observed during follow-up, respectively. After matching, no statistically significant difference in bleeding (hazard ratio, 0.88; 95% confidence interval, 0.64–1.21) or thromboembolic (hazard ratio, 1.10; 95% confidence interval, 0.72–1.69) risk was observed between dabigatran and VKA new users. Bleeding (hazard ratio, 0.98; 95% confidence interval, 0.64–1.51) and ischemic (hazard ratio, 0.93; 95% confidence interval, 0.47–1.85) risks were comparable between rivaroxaban and VKA new users.

Conclusions—
In this propensity-matched cohort study, our findings suggest that physicians should exercise caution when initiating either non-VKA oral anticoagulants or VKA in patients with nonvalvular atrial fibrillation.
Validation of the Valve Academic Research Consortium Bleeding Definition in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation
Authors: Stortecky Stefan , Stefanini Giulio G. , Pilgrim Thomas , Heg Dik , Praz Fabien , Luterbacher Fabienne , Piccolo Raffaele , Khattab Ahmed A. , Räber Lorenz , Langhammer Bettina , Huber Christoph , Meier Bernhard , Jüni Peter , Wenaweser Peter , Windecker Stephan 
Published: September 2015

Background

The Valve Academic Research Consortium (
VARC
) has proposed a standardized definition of bleeding in patients undergoing transcatheter aortic valve interventions (
TAVI
). The
VARC
bleeding definition has not been validated or compared to other established bleeding definitions so far. Thus, we aimed to investigate the impact of bleeding and compare the predictivity of
VARC
bleeding events with established bleeding definitions.

Methods and Results

Between August 2007 and April 2012, 489 consecutive patients with severe aortic stenosis were included into the Bern‐
TAVI
‐Registry. Every bleeding complication was adjudicated according to the definitions of
VARC
,
BARC
,
TIMI
, and
GUSTO
. Periprocedural blood loss was added to the definition of
VARC
, providing a modified
VARC
definition. A total of 152 bleeding events were observed during the index hospitalization. Bleeding severity according to
VARC
was associated with a gradual increase in mortality, which was comparable to the
BARC
,
TIMI
,
GUSTO
, and the modified
VARC
classifications. The predictive precision of a multivariable model for mortality at 30 days was significantly improved by adding the most serious bleeding of
VARC
(area under the curve [
AUC
], 0.773; 95% confidence interval [
CI
], 0.706 to 0.839),
BARC
(
AUC
, 0.776; 95%
CI
, 0.694 to 0.857),
TIMI
(
AUC
, 0.768; 95%
CI
, 0.692 to 0.844), and
GUSTO
(
AUC
, 0.791; 95%
CI
, 0.714 to 0.869), with the modified
VARC
definition resulting in the best predictivity (
AUC
, 0.814; 95%
CI
, 0.759 to 0.870).

Conclusions

The
VARC
bleeding definition offers a severity stratification that is associated with a gradual increase in mortality and prognostic information comparable to established bleeding definitions. Adding the information of periprocedural blood loss to
VARC
may increase the sensitivity and the predictive power of this classification.
Two new species of the genus Aalatettix Zheng &amp; Mao (Orthoptera, Tetrigoidea, Tetrigidae) from Taiwan, China
Authors: ZHENG FANG-QIANG , SHI JIAN-PING , YIN ZHAN 
Published: September 2015

Two new species of the genus Aalatettix Zheng & Mao, 2002, namely Aalatettix yangi sp. nov. and Aalatettix xiai sp. nov. are described and illustrated. The new species Aalatettix yangi sp. nov. is allied to Aalatettix gibbosa Zheng, Cao & Chen, 2011, but upper margin of pronotum waved in lateral view, width of frontal ridge narrower than width of basal joint of antennae, hind tibiae dark brown, base not pale. The new species Aalatettix xiai sp. nov. is allied to Aalatettix yangi sp. nov., but length of pronotum shorter, not reaching epiproct, width of vertex 1.5 times diameter of eye, lateral carinae of pronotum contracted backward distinctly, posterior apex of lower margin angular on lateral lobe of pronotum, lower margin of median femur waved, antennae placed under lower margin of eyes. The type specimens are deposited in the National Museum of Natural Science, Taichung, Taiwan, China.
Ewolucja niektórych elementów stereotypu psa w polszczyźnie
Authors: Raszewska-Żurek Beata 
Published: September 2015

The evolution of dog’s view in Polish languageThe article presents the evolution of dog’s view in Polish language within the centuries – from Old Polish to the present, considering vocabulary dialect.The components of a dichotomous present stereotype of dog (the two negative ones and one positive) are analyzed in the work. The negative ones seem to belong to the older structure of the language. The example of association with “a lie” – in Polish łże jak pies – and its metaphorical meaning of the verb, is well-known from the Old Polish and still used, however, less frequent. The phenomenon seems to be similar to the attributing a dog with its small value, as it is documented in the used meanings of adjectives such as: psi / pieski (‘dog-ass’).Late testified, but extremely important element of the dog’s view, is associating it with dog’s fidelity that was expressed in a phrase wierny jak pies – that is focused on being a faithful dog.This combination of two meanings resulting in its dichotomy, and even its internal contradiction, rejected the negative stereotype of a dog.Nowadays, due to the cultural changes including our attitude to animals generally, especially domestic ones, its primary association with fidelity seems to be priority.
Słowiańskie nazwy ‘brwi’ w świetle materiałów gwarowych i źródeł historycznych
Authors: Siatkowski Janusz 
Published: September 2015

Slavic names for ‘eyebrows’ in light of dialectal materials and historical sources‘Eyebrows’ have in OlA only several more frequent names (that are marked on the map by areas), the remaining ones occupy small areas or are absolutely rare.The most frequent names are those connected with the core *-brъv-, that are internally very different. There is an expressive contrast/opposition between the northern area with forms from *brъv- and the large southern area with the forms from prefixed *obrъv-. The forms from the core *-brъv- are also divided into two areas due to the preservation of the indigenous [old Slavonic semivowel] “jor/jer”: in the west, the forms with the disappeared weak “jor” exist in the west, while in the each these forms show its secondary vocalization. These macro-divisions also include the differentiations that are the result of morphological transformations of primary forms *bry, *brъve and *obry, *obrъve that show the early transition to -i stems with the accusative form in the nominative case, in turn the transition to former -a stems or to former -ja stems, the emergence of the secondary form of the neuter *obrъvьje, and finally – most probably due to the treatment of the form of the singular of the feminine gender *(o)brъva as the plural form and its depluralization – the emergence of the singular of the neuter *(o)brъvo.Vast areas are formed by forms from *vědja (in pl *vědję or *vědji) in the eastern part of the southern Slavic languages and by forms from the base *ob-oč- (or most frequently *//obočьje) in the Czech Republic, Morava and Slovakia and as the island-like presence can be found in Lusatia (Łużyce) and in Hungary.
Community factors influencing child and adolescent depression: A systematic review and meta-analysis
Authors: Stirling Katie , Toumbourou John W , Rowland Bosco 
Published: September 2015

Objective: Depression has been identified as a priority disorder among children and adolescents. While numerous reviews have examined the individual and family factors that contribute to child and adolescent depressive symptoms, less is known about community-level risk and protective factors. The aim of this study was to complete a systematic review to identify community risk and protective factors for depression in school-aged children (4–18 years). Method: The review adopted the procedures recommended by the Cochrane Non-Randomised Studies Methods Working Group and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted to identify both observational and intervention study designs in both peer-reviewed and non-peer reviewed publications. Results: A total of 21 studies met the inclusion criteria. Seventeen of the 18 community association studies and 2 of the 3 intervention studies reported one or more significant effects. Results indicated that community safety and community minority ethnicity and discrimination act as risk factors for depressive symptoms in school-aged children. Community disadvantage failed to achieve significance in meta-analytic results but findings suggest that the role of disadvantage may be influenced by other factors. Community connectedness was also not directly associated with depressive symptoms. Conclusion: There is evidence that a number of potentially modifiable community-level risk and protective factors influence child and adolescent depressive symptoms suggesting the importance of continuing research and intervention efforts at the community-level.