bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improve the Understanding of Argumentation Texts in Vocational Students Through Strategies to Simplify Text Structure
Authors: Artika Nurrahma Hareindy  , Dewi Kusumaningsi  , Loliek Kania Atmaja  , Eli Rustinar  , Wahyudiniseptiari  
Published: August 2024

Discussion of various kinds of text structures plays an important role in utilizing argumentative texts. This study aims to improve students' understanding of argumentation texts. The formulation of the problem in this study is 1. What are the factors that make students less understanding of argumentation texts. 2. How to improve student understanding. Data sources in this study were voice recordings, note-taking and interviews. In this study, researchers use a qualitative approach method because it is based on reality and events that take place in the field, namely about how to improve the understanding of argumentation texts in vocational students through simplification of texts. The reason researchers use a qualitative approach is because researchers can focus attention on natural events that occur and are experienced by students. In addition, researchers also conduct their own observations, interviews, and reveal the data obtained in depth. This study used data collection techniques in the form of observation, interviews and documentation. In qualitative research, this is carried out in various ways, one of which is the researcher goes directly into the field. The results of this study were seen from the research sample used 50% of the population from the calculation for class XI Broadcasting 1 SMKN 3 students of Bengkulu City which amounted to 28 students taken 50%, namely 14 students. So the sample in this study was class XI Broadcasting 1 students totaling 14 students. The structure of the argumentation text itself, namely the introduction, the body of the argument and the conclusion. Based on the results of the assessment of argumentation text comprehension through a strategy of simplifying the text structure of 14 students, 7 male students and 7 female students, the average is 87.35. There were 7 students who were in the very good category and 7 students who were in the good category. The source of the data obtained in this study is in the form of student values. Judging from the object to be obtained, this research is included in the type of descriptive research using qualitative methods. Descriptive research is research conducted to find out the value of one or more variables without making comparisons and linking with other variables.
Inner Conflict of Dewa's Character in the Novel Invalidite by Faradita: A Study of Humanistic Psychology
Authors: Raja Gukguk M Evelina , Dicky Rachmat Pauji  , Kurnia Rachmawati  
Published: August 2024

The objective of this research is to elucidate three key aspects related to Dewa's character in the novel "Invalidite": (1) the internal conflicts experienced by Dewa, (2) the various manifestations of these inner conflicts, and (3) an exploration of Dewa's unmet needs within the context of the novel "Invalidite." This research methodology uses a descriptive qualitative approach. Data collection techniques involve meticulous reading and note-taking, tailored to the primary data source, namely Faradita's novel "Invalidite." The researcher engaged in a thorough examination of the novel's text, systematically documenting all information about Dewa's inner conflicts. Additionally, relevant data such as words, sentences, or paragraphs depicting Dewa's inner conflicts, behaviors, and unfulfilled needs were identified and recorded. This research reveals distinct forms of inner conflict within Dewa's character, encompassing anxiety, trauma, fear, anger, and indecision. Furthermore, this research sheds light on Dewa's unmet needs as the primary drivers of his internal conflicts, specifically: (1) unfulfilled physiological need, (2) unmet need for security, (3) unmet need for love and affection, and (4) unmet need for recognition. In summary, this research provides a comprehensive understanding of the inner conflicts and unmet needs of Dewa's character in the novel "Invalidite," drawing on Abraham Maslow's framework. The identified forms of inner conflict and unfulfilled needs contribute to a nuanced exploration of Dewa's psychological landscape in the narrative.
Pengaruh Senam Lansia Sebagai Terapi Non Farmakologi dalam Menurunkan Tekanan Darah Pada Lansia
Authors: Huzaifah Zaqyyah , Sari Rohni Taufika , Rahayu Suci Fitri 
Published: August 2024

Latar Belakang: Gaya hidup masyarakat yang lebih seperti makanan cepat saji dan kurang gerak dapat menyebabkan berbagai masalah kesehatan termasuk hipertensi, gagal jantung, diabetes mellitus, stroke, dan penyakit ginjal. Hipertensi merupakan masalah kesehatan yang dialami oleh banyak orang lanjut usia (lansia). Salah satu cara untuk mencegah komplikasi hipertensi dan untuk melatih lansia untuk aktif bergerak adalah dengan memberikan intervensi senam lansia. Tujuan: Untuk mengetahui pengaruh senam lansia sebagai terapi non farmakologi dalam menurunkan tekanan darah pada lansia.Metode: Penelitian ini merupakan penelitian kuantitatif dengan menggunakan rancangan penelitian Quasy Eksperiment dengan desain one group Pre and Post test design. Subjek pada penelitian ini adalah lansia yang berada pada wilayah kerja Puskesmas Kuin Raya sebanyak 32 orang.Hasil: uji statistik menggunakan uji wilcoxon didapatkan nilai p value 0,000 yang mana nilai tersebut lebih kecil dari nilai α sehingga hipotesis diterima yaitu ada pengaruh senam lansia sebagai terapi non farmakologi dalam menurunkan tekanan darah pada lansia.Kesimpulan: Pengobatan hipertensi khususnya pada lansia perlu mendapatkan modifikasi dengan menambahkan terapi nonfarmakologi yaitu dengan melakukan senam lansia sehingga efek pengobatan lebih cepat dicapaiKata Kunci: Senam Lansia, Hipertensi, NonfarmakologiThe Effect of Elderly Exercise as a Non-Pharmacological Therapy in Lowering Blood Pressure in the ElderlyBackground: People's lifestyles that include fast food and lack of movement can cause various health problems including hypertension, heart failure, diabetes mellitus, stroke and kidney disease. Hypertension is a health problem experienced by many elderly people. One way to prevent hypertension complications and to train the elderly to be active is to provide elderly exercise interventions.Objective: To determine the effect of elderly exercise as a non-pharmacological therapy in lowering blood pressure in the elderly.Method: This research is a quantitative research using a Quasy Experiment research design with a one group Pre and Post test design. The subjects in this study were 32 elderly people who were in the working area of the Kuin Raya Community Health Center.Results: statistical tests using the Wilcoxon test obtained a p value of 0.000, which is smaller than the α value so that the hypothesis is accepted, namely that there is an effect of elderly exercise as a non-pharmacological therapy in lowering blood pressure in the elderly.Conclusion: Treatment of hypertension, especially in the elderly, needs to be modified by adding non-pharmacological therapy, namely by doing elderly exercises so that the treatment effect is achieved more quickly.
Association between stress hyperglycemia ratio and all-cause mortality in critically ill patients with atrial fibrillation: insights from a MIMIC-IV study
Authors: Liu Lin , Zhu Zhanfang , Yu Kai , Zhang Wei , Pu Jie , Lv Ying , Tang Zhiguo , Liu Fuqiang , Liu Shasha 
Published: August 2024

BackgroundThe stress hyperglycemia ratio (SHR) has emerged as a potential prognostic indicator for various critical illnesses. However, its role in determining outcomes in patients with atrial fibrillation (AF) within the intensive care unit (ICU) remains unclear. This study aimed to elucidate the association between SHR and all-cause mortality in this clinical setting.MethodsWe conducted a retrospective cohort study utilizing data from a large, retrospective database. Critically ill patients with documented AF were stratified based on quartiles of SHR. The primary outcome was 365-day all-cause mortality, with secondary outcomes including 90-day and 28-day mortality. COX proportional hazards models adjusted for confounders and Kaplan-Meier curve analyses were used to explore the relationship between SHR and mortality.Results2,679 patients with critical AF were enrolled in the final study. Among the patients studied, those in the highest SHR quartiles exhibited an increased risk of 365-day all-cause mortality (HR:1.32, 95%CI=1.06-1.65). Notably, in subgroup analyses, the prognostic value of SHR was particularly pronounced in patients with hypertension. Sensitivity analyses confirmed the persistence of these findings after excluding cohorts with malignant tumors, and heart failure.ConclusionsOur research discerns a positive association between SHR and all-cause mortality in critically ill patients with AF, highlighting the significance of acute glycemic dysregulation on patient outcomes. Longer follow-up is still needed in the future to study the association between SHR and all-cause mortality in critically ill patients with AF.
JAK inhibitors to treat STAT3 gain-of-function: a single-center report and literature review
Authors: Atschekzei Faranaz , Traidl Stephan , Carlens Julia , Schütz Katharina , von Hardenberg Sandra , Elsayed Abdulwahab , Ernst Diana , Risser Linus , Thiele Thea , Graalmann Theresa , Raab Juliana , Baumann Ulrich , Witte Torsten , Sogkas Georgios 
Published: August 2024

ObjectiveThe signal transducer and activator of transcription 3 (STAT3) gain-of-function (GOF) syndrome (STAT3-GOF) is an inborn error of immunity (IEI) characterized by diverse manifestations of immune dysregulation that necessitate systemic immunomodulatory treatment. The blockade of the interleukin-6 receptor and/or the inhibition of the Janus kinases has been commonly employed to treat diverse STAT3-GOF-associated manifestations. However, evidence on long-term treatment outcome, especially in the case of adult patients, is scarce.MethodsClinical data, including laboratory findings and medical imaging, were collected from all seven patients, diagnosed with STAT3-GOF, who have been treated at the Hannover University School, focusing on those who received a Janus kinase (JAK) inhibitor (JAKi). Previously published cases of STAT3-GOF patients who received a JAKi were evaluated, focusing on reported treatment efficacy with respect to diverse STAT3-GOF-associated manifestations of immune dysregulation and safety.ResultsFive out of seven patients diagnosed with STAT3-GOF were treated with a JAKi, each for a different indication. Including these patients, outcomes of JAKi treatment have been reported for a total of 41 patients. Treatment with a JAKi led to improvement of diverse autoimmune, inflammatory, or lymphoproliferative manifestations of STAT3-GOF and a therapeutic benefit could be documented for all except two patients. Considering all reported manifestations of immune dysregulation in each patient, complete remission was achieved in 10/41 (24.4%) treated patients.ConclusionsJAKi treatment improved diverse manifestations of immune dysregulation in the majority of STAT3-GOF patients, representing a promising therapeutic approach. Long-term follow-up data are needed to evaluate possible risks of prolonged treatment with a JAKi.
Essential amino acid carbon isotope ratios as indicators of marine macrophyte response to environmental variation
Authors: Yun Hee Young , Kim Sangil , Choi Hyuntae , Kim Ji-Eun , Park Sang Rul , Shin Kyung-Hoon 
Published: August 2024

IntroductionThe carbon isotope ratios (δ13C) of essential amino acids (EAAs), including valine, leucine, isoleucine, threonine, and phenylalanine, in producers are crucial for explaining food-web structures in marine ecosystems. However, few studies have tested the variability of δ13C-EAA values in marine macrophytes, such as seagrass and macroalgae, under changing environmental conditions.MethodsIn this study, we examined the responses of δ13C-EAA values in macrophytes to environmental changes and explored their usefulness in characterizing macrophyte groups and local environments. We tested seagrass and macroalgae collected at different spatial and temporal scales in the field, as well as lab-cultured Ulva algae at various temperature gradients (12°C, 20°C, and 27.5°C) with additional nitrogen sources.ResultsWe found that δ13C-EAA values in macroalgae were significantly altered by seasonality and the interactive effects of temperature and nitrogen addition in comparison with mean-centered δ13C-EAA values (normalized δ13C-EAA values relative to the mean of the overall EAAs). The δ13C-EAA values detected in macroalgae within a local environment correlated with those of a co-occurring grazer, Caprella. Based on mean-centered δ13C-EAA values, macrophyte groups were distinguishable from other group (i.e., the bacteria group) even under diverse environmental conditions. Moreover, the seagrass group did not overlap with the green and the brown macroalgal group, but overlapped considerably with the red macroalgal group.DiscussionThese results suggest that the macrophyte-specific mean-centered δ13C-EAA values may be fairly consistent across broad spatial and temporal scales. Despite significant variation in δ13C-EAA values, the consistency in mean-centered δ13C-EAA values among specific macrophyte groups provides valuable insight into the characteristics of local trophic bases in regions under pressure from dramatic environmental changes.
Efficacy and safety of Janus kinase inhibitors in non-infectious inflammatory ocular diseases: a prospective cohort study from the international AIDA network registries
Authors: Vitale Antonio , Palacios-Olid Judith , Caggiano Valeria , Ragab Gaafar , Hernández-Rodríguez José , Pelegrín Laura , Mejía-Salgado Germán , Zarate-Pinzón Laura , Gentileschi Stefano , Sota Jurgen , Fonollosa Alex , Carreño Ester , Gaggiano Carla , Amin Rana Hussein , Balistreri Alberto , Narváez Javier , Tosi Gian Marco , Frediani Bruno , Cantarini Luca , de-la-Torre Alejandra , Fabiani Claudia 
Published: August 2024

IntroductionNon-infectious inflammatory ocular diseases pose significant challenges in diagnosis and management, often requiring systemic immunosuppressive therapy. Since Janus kinase (JAK) inhibitors may represent a novel therapeutic option for these disorders, the present study aimed to expand current knowledge about their efficacy and safety in patients with these conditions.MethodsThis prospective cohort study included 12 adult patients from the international AutoInflammatory Disease Alliance (AIDA) Network registries dedicated to non-infectious ocular inflammatory conditions. We assessed ocular flares, visual acuity, disease course, and complications before and after initiating JAK inhibitor therapy.ResultsOcular inflammation was related to a systemic disease in 8 (66.7%) patients as follows: spondyloarthritis (n = 3), peripheral psoriatic arthritis (n = 1), rheumatoid arthritis (n = 1), antinuclear antibodies (ANA) positive juvenile idiopathic arthritis (n = 1), Behçet’s syndrome (n = 1), Vogt-Koyanagi-Harada syndrome (n = 1). In total, 4 patients received baricitinib, 1 patient received tofacitinib, and 7 patients underwent upadacitinib treatment. The overall average duration of JAK inhibitors treatment was 8.6 ± 5.5 months (ranging from 3 to 20 months). At the last assessment, ocular disease control was complete in 12/12 patients. One patient discontinued baricitinib due to poor compliance after a 12-month relapse-free period. The incidence of ocular flares was 125 episodes/1.000 person-months prior to the initiation of JAK inhibitors and 28.6 episodes/1.000 person-months thereafter. The incidence rate ratio for experiencing a relapse before starting a JAK inhibitor compared to the following period was 4.37 (95% CI 1.3–14.7, p-value: 0.02).ConclusionJAK inhibitors demonstrate efficacy and safety in controlling ocular inflammatory relapses, confirming that they represent a valuable treatment option for patients with non-infectious inflammatory ocular diseases resistant to conventional treatments.
Exercise and brain health in patients with coronary artery disease: study protocol for the HEART-BRAIN randomized controlled trial
Authors: Toval Angel , Solis-Urra Patricio , Bakker Esmée A. , Sánchez-Aranda Lucía , Fernández-Ortega Javier , Prieto Carlos , Alonso-Cuenca Rosa María , González-García Alberto , Martín-Fuentes Isabel , Fernandez-Gamez Beatriz , Olvera-Rojas Marcos , Coca-Pulido Andrea , Bellón Darío , Sclafani Alessandro , Sanchez-Martinez Javier , Rivera-López Ricardo , Herrera-Gómez Norberto , Peñafiel-Burkhardt Rafael , López-Espinosa Víctor , Corpas-Pérez Sara , García-Ortega María Belén , Vega-Cordoba Alejandro , Barranco-Moreno Emilio J. , Morales-Navarro Francisco J. , Nieves Raúl , Caro-Rus Alfredo , Amaro-Gahete Francisco J. , Mora-Gonzalez Jose , Vidal-Almela Sol , Carlén Anna , Migueles Jairo H. , Erickson Kirk I. , Moreno-Escobar Eduardo , García-Orta Rocío , Esteban-Cornejo Irene , Ortega Francisco B. 
Published: August 2024

IntroductionPatients with coronary artery disease (CAD) have a higher risk of developing cognitive impairment and mental health disorders compared to the general population. Physical exercise might improve their brain health. The overall goal of the HEART-BRAIN randomized controlled trial (RCT) is to investigate the effects of different types of exercise on brain health outcomes in patients with CAD, and the underlying mechanisms.MethodsThis three-arm, single-blinded RCT will include 90 patients with CAD (50–75 years). Participants will be randomized into: (1) control group—usual care (n = 30), (2) aerobic high-intensity interval training (HIIT) (n = 30), or (3) HIIT combined with resistance exercise training (n = 30). The 12-week intervention includes 3 supervised sessions (45-min each) per week for the exercise groups. Outcomes will be assessed at baseline and post-intervention. The primary outcome is to determine changes in cerebral blood flow assessed by magnetic resonance imaging. Secondary outcomes include changes in brain vascularization, cognitive measures (i.e., general cognition, executive function and episodic memory), and cardiorespiratory fitness. Additional health-related outcomes, and several potential mediators and moderators will be investigated (i.e., brain structure and function, cardiovascular and brain-based biomarkers, hemodynamics, physical function, body composition, mental health, and lifestyle behavior).ConclusionThe HEART-BRAIN RCT will provide novel insights on how exercise can impact brain health in patients with CAD and the potential mechanisms explaining the heart-brain connection, such as changes in cerebral blood flow. The results may have important clinical implications by increasing the evidence on the effectiveness of exercise-based strategies to delay cognitive decline in this high-risk population.Clinical trial registrationClinicalTrials.gov, identifier [NCT06214624].
Brain growth until adolescence after a neonatal focal injury: sex related differences beyond lesion effect
Authors: Postic Pierre-Yves , Leprince Yann , Brosset Soraya , Drutel Laure , Peyric Emeline , Ben Abdallah Ines , Bekha Dhaif , Neumane Sara , Duchesnay Edouard , Dinomais Mickael , Chevignard Mathilde , Hertz-Pannier Lucie 
Published: August 2024

IntroductionEarly focal brain injuries lead to long-term disabilities with frequent cognitive impairments, suggesting global dysfunction beyond the lesion. While plasticity of the immature brain promotes better learning, outcome variability across individuals is multifactorial. Males are more vulnerable to early injuries and neurodevelopmental disorders than females, but long-term sex differences in brain growth after an early focal lesion have not been described yet. With this MRI longitudinal morphometry study of brain development after a Neonatal Arterial Ischemic Stroke (NAIS), we searched for differences between males and females in the trajectories of ipsi- and contralesional gray matter growth in childhood and adolescence, while accounting for lesion characteristics.MethodsWe relied on a longitudinal cohort (AVCnn) of patients with unilateral NAIS who underwent clinical and MRI assessments at ages 7 and 16 were compared to age-matched controls. Non-lesioned volumes of gray matter (hemispheres, lobes, regions, deep structures, cerebellum) were extracted from segmented T1 MRI images at 7 (Patients: 23 M, 16 F; Controls: 17 M, 18 F) and 16 (Patients: 18 M, 11 F; Controls: 16 M, 15 F). These volumes were analyzed using a Linear Mixed Model accounting for age, sex, and lesion characteristics.ResultsWhole hemisphere volumes were reduced at both ages in patients compared to controls (gray matter volume: −16% in males, −10% in females). In ipsilesional hemisphere, cortical gray matter and thalamic volume losses (average −13%) mostly depended on lesion severity, suggesting diaschisis, with minimal effect of patient sex. In the contralesional hemisphere however, we consistently found sex differences in gray matter volumes, as only male volumes were smaller than in male controls (average −7.5%), mostly in territories mirroring the contralateral lesion. Females did not significantly deviate from the typical trajectories of female controls. Similar sex differences were found in both cerebellar hemispheres.DiscussionThese results suggest sex-dependent growth trajectories after an early brain lesion with a contralesional growth deficit in males only. The similarity of patterns at ages 7 and 16 suggests that puberty has little effect on these trajectories, and that most of the deviation in males occurs in early childhood, in line with the well-described perinatal vulnerability of the male brain, and with no compensation thereafter.