bluuebunny/crossref_metadata_2025_split huggingface dataset:
1641 – Family Burden-focused Psychosocial Therapy With Parents And Social Functioning Of Children And Adolescents With Schizophrenic Spectrum Disorders
Authors: Koren E. , Kupriyanova T. 
Published: July 2013

IntroductionFamily burden is considered to be an integrated psychosocial parameter negatively impacting on symptom levels, social functioning and outcomes of children and adolescents with schizophrenic spectrum disorders, and specific measures directly aimed at lessening the burden of these families should be developed.ObjectiveTo assess the influence of burden-focused group therapy (BFGT) with parents on social functioning of children and adolescents with schizophrenic spectrum disorders.MethodsParents of 126 children with administered standard antipsychotic therapy (aged 8 - 17 years) were recruited into this study. Parents were assigned to eight 90-minutes “module” structured sessions carried out in groups (8 - 9 members) and received a systematic assessment using CGSQ and CGAS at entry and after 1, 3 and 6 month.ResultsReciprocal effect with negative correlation (r=-0.463, P=0.005) between family burden indicators and children's total levels of functioning was established. BFGT did significantly affect family burden and correlated with positive changes in overall levels of social functioning of children using CGAS (p< 0,05). The largest decline was noted in Subjective burden (from 4.98 to 3.75).ConclusionsBFGT aimed at managing family burden and improving children's social functioning proved to be one of key components of the psychosocial treatment and rehabilitation of children and adolescents with schizophrenic spectrum disorders in the context of increasing rehabilitation resource of their families. Further controlled studies are required to strengthen the evidence base for effective management of family burden.
1648 – What Do Adolescents Know About Depression? Efficacy And Utility Of An Information Booklet
Authors: Allgaier A.-K. , Schiller Y. , Eberle-Sejari R. , Schulte-Körne G. 
Published: July 2013

IntroductionAdolescents still lack knowledge about depression and its treatment. As a result, depressed adolescents are confronted with stigmata that are barriers to treatment-seeking. Studies in adults demonstrated that depression literacy can be increased by educational material.ObjectivesWe developed an information booklet on depression specifically addressing adolescents aged 13 to 17. For the first time, it was examined whether knowledge about depression in youth can be enhanced by reading an educational leaflet.MethodsThe information booklet was evaluated in 628 German ninth graders (M= 15.1 years, 58% boys) in a pre-postfollow- up design.Using study-specific questionnaires, knowledge about seven topics on depression was assessed. Key subjects were symptoms and treatment of depression as well as suicidality.In addition, students evaluated the booklet's layout, content and utility.ResultsPower-analysis of the pre-post-follow-up-comparison yielded effect sizes of knowledge enhancement between eta2 = 0.07 (medium) and 0.56 (large) for all topics of the booklet.The largest effect sizes were found for the topics “symptoms” and “antidepressants”. Sub-analysis on school types and gender showed the highest increase in knowledge in well-educated students and in girls. The participating youth assessed the booklet positively regarding all categories, with a mean overallrating of 2.15 on a scale from 1 (very good) to 6 (fail).ConclusionsAlthough students’ baseline knowledge about depression was good, girls and boys of all school types significantly increased depression literacy. Thus, the booklet can help reducing stigmata and treatment barriers in adolescents.
1651 – WAVE-bd, An Ambispective Multinational Observational Study On Bipolar i And Ii Disorder (bdi, Bdii): French Cohort Clinical Outcomes (nct01062607)
Authors: Bellivier F. , Coulomb S. , Vega C. , Lukasiewicz M. , Vieta E. , Figueira M.L. , Souery D. , Langosch J.M. ,   WAVE-bd Scientific Board
Published: July 2013

IntroductionWAVE-bd provides information on the clinical management and outcomes of BDI and II patients in daily clinical practice.Aim/objectiveTo describe French patients (n=480) clinical outcomes up to 18 months.MethodsWAVE-bd included patients with ≥1 mood event (index episode) in the preceding 12 months before inclusion and followed ≥ 9 months (total participation 12 to 27 months).Results2896 patients were analysed worldwide, 17% in France (53% in private practice, 47% in public practice): mean age 47 years (SD: 12.51), women, 65%; BD-I, 59%; BD-II, 41%; index event depressive, 64%; hypomanic, 21%; manic, 9%; mixed, 6%.During follow-up, 77 patients (16%) reported relapses (1.25 patient-years; 95%CI = [1.04; 1.49]) and 176 patients (37%) reported recurrences (0.65 patient-years; 95%CI = [0.57; 0.74]). The most common type of reported recurrence (n; %) was depressive (114; 24%) rather than hypomanic (64; 13%), manic (14; 3%) or mixed (11; 2%). Suicide attempt was reported in 25 patients (5,2%, 0.046 patient-years; 95%CI=[0.031;0.064]). The most common type of treatment during manic and hypomanic episodes was atypical antipsychotics AAP (69% and 49%, respectively) while during depressive episodes, the most common types of treatment were antidepressants (82%).ConclusionsThese results show a high incidence of relapse and recurrence of mood events and the more frequent depressive polarity in BD patients in France. Further analyses are required to evaluate which factors influenced the severity (relapse, recurrence and suicidality) of the disease. Overall, antipsychotics and antidepressants were most commonly prescribed for manic and depressive episodes, respectively.
1653 – The Developemnt Of Adaptive And Maladaptive Patterns Of Internet Use Among European Adolescents At Risk For Internet Addictive Behaviors: a Grounded Theory Inquiry
Authors: Dreier M. , Tzavela E. , Wölfling K. , Mavromati F. , Duven E. , Karakitsou C. , Macarie G. , Veldhuis L. , Wójcik S. , Halapi E. , Sigursteinsdottir H. , Oliaga A. , Tsitsika A. 
Published: July 2013

IntroductionFull findings from the European Commission funded EU-NET-ADB study (Safer Internet Programme) will be presented.ObjectivesEmpirical findings that elucidate the development of an internet addictive behaviour are still incomplete. This is also related to risk as well as protective factors of internet use. Here a process oriented approach to identify underlying conditions of an internet addictive behaviour was chosen.AimsThe aim of the study is to enhance the knowledge and understanding of underlying processes which lead to situation were internet addictive behaviour can evolve.MethodsIn total 124 in-depth interviews were conducted with adolescents with an age of 14-17 year. Adolescents from seven different European countries (Greece, Spain, Poland, Germany, Romania, Netherlands & Iceland) participated in this study. Eligibility was granted when adolescents scored more than 30 point or equal in the Internet Addiction Test (IAT; Young, 1998). Data analysis was conducted by use of a step-wise full version of Grounded Theory (Strauss & Corbin, 1990; 1998).ResultsAdolescents employed maladaptive and adaptive strategies in regard to their involvement in the internet. Thus different Digital Outcomes such as “I am addicted” (Stuck Online) ranging to more adaptive internet behaviour like (Juggling it All) and patterns of self-correcting (Coming Full Cycle) were identified. These Digital Outcomes were consequently linked to adolescent's developmental pathways and can be characterized by the core category “Navigating Adolescent Pathways”.ConclusionsContextual and developmental factors that mediate the development of an internet addictive behaviour could be identified and linked to multiple Digital Outcomes.
1654 – Efficacy Of Aripiprazole On Behavioural Symptoms In Three Young Patients With Severe Acquired Brain Injury
Authors: Piccoli S. , Pizzighello S. , Martinuzzi A. 
Published: July 2013

The atypical antipsychotic drug aripirprazole has a partial agonist activity on the dopamine receptors. This characteristic makes aripiprazole different from other antipsychotic agents.In this paper, we aim to describe the use of this drug in the management of three young patients with acquired brain injury: a woman with Wilsons disease, a male with a rupture of an arteriovenous malformation and a male with severe traumatic brain injury.All patients presented behavioural symptoms. One of them presented frequent crises of psychomotor agitation with strong physical aggressive reaction, partial awareness and low frustration tolerance. The other two patients reported a prevalence of negative symptoms, as inactivity, apathy, lack of will and severe perseveration.They were referred to our Unit and were evaluated with a full functional assessment at the moment of admission and at the discharge, depending on their clinical picture. The evaluation included: MMSE (Mini Mental State Examination), LCF (Level of Cognitive Functioning), DRS (Disability Rating Scale) and FIM (Functional Independence Measure). The behavioural assessment was made with clinical interviews.After the introduction of aripiprazole, we found an improvement in the behavioural pattern, moreover neuropsychological and motor evaluation appeared not affected.These results suggest that the use of aripiprazole in patients with acquired brain injury is suitable for its efficacy in reducing psychotic and behavioural symptoms but also for its potential for not affecting motor and cognitive functioning.
1655 – Suicide Attempt Prediction In a Controlled Study Of Case Management In The Prevention Of Recurrent Suicidal Behaviour
Authors: Burón P. , Al-Halabí S. , Garrido M. , Rodríguez-Revuelta J. , García-Álvarez L. , González-Blanco L. , García-Portilla P. , Sáiz P.A. , Bobes J. 
Published: July 2013

IntroductionInformation about the perception of suicide attempters regarding prevention of their suicide attempt may be helpful in implementing preventive strategies.AimTo examine:(i)sociodemographic profile,(ii)distribution of the Suicide Intent Scale, and(iii)differences according to the gender in the sample of participants in a controlled study to determine the effectiveness of case management programme in the prevention of recurrent suicidal behaviour.Method106 suicide attempters who attended the Emergency Room of the Hospital of Asturias from July- 2011 to October- 2012 were included in the study [33% males; mean age (SD)= 41.82 (13.16)]. Instruments: Ad hoc Sociodemographic- Questionnaire; Suicide Intent Scale (SIS); SAD-PERSON Scale; Medical Damage Scale; List of Threatening Experiences; Hamilton Depression Rating Scale.ResultsProfile: 45-54 years old (30.4%), married (34%), with bachelor's degree (42.5%), unemployed (29.2%), with children (61.3%) and living with partner (34.9%). 36.2% of the sample had the intention to repeat at the time of the suicide attempt (SA), while 22.6% actually repeated it. The intention to repeat the SA was associated with the commission of SA at 12-months follow-up (p=.002). SIS data: mean total score (SD)=15.99(4.71); mean objective score (SD)=5.69(2.48); mean subjective score (SD)=10.28(3.29). Significant differences in SIS scores were found by gender (p=.007), men scoring higher. Repetition of the SA was related with higher scores (p=.002).ConclusionsSA severity and its repetition at 12-months follow-up was related with the intention of repetition; nevertheless we didn’t find relation between the SA severity and the repetition of SA one year later.
1660 – Prevalence And Associated Factors Of Anxiety After Deep Brain Stimulation At Subthalamic Nucleus(stn-dbs) In Patients With Parkinson's Disease
Authors: Pariwatcharakul P. , Shotbolt P. , Clough C. 
Published: July 2013

IntroductionDeep brain stimulation (DBS) for Parkinson's disease (PD) has emerged as a treatment with very good motor outcomes. However, a higher prevalence of anxiety following DBS has been reported.ObjectivesTo study the prevalence and associated factors of anxiety following STN-DBSMethodsData were retrospectively collected from medical records of PD patients who underwent STN-DBS at King's College Hospital, London from 2001 to 2010. Neuropsychiatric assessments were done pre-STN-DBS at baseline, and also approximately 6 months after the surgery.ResultsFifty eight PD patients underwent STN-DBS. After patients with missing data (n=2), patients who were not referred for post-DBS neuropsychiatric evaluation (n=5) were excluded, 51 patients were studied. Their mean age was 61.2±7.1 years old and the mean PD duration was 12±5.2 years. Post-STN-DBS anxiety was found in 8 patients (15.7%). All of them underwent bilateral STN-DBS and had uneventful recovery. Significant associated factors were female gender (n=6; 75.0%; p=0.056) and new-onset post-DBS apathy (n=7, 87.5%, p=0.0001). However, memory impairment (n=4; 50%; p=0.076) and depression post-DBS (n=4, 50%, p=0.055) did not show statistically significant associations.ConclusionsThe prevalence of post-STN-DBS anxiety in our study (15.7%) was lower than that from the previous reports in PD patients who received medication (25-43%) and STN-DBS (40%). The associated factors were similar to those reported in medication-treated PD patients. Given relatively low prevalence of anxiety following the operation, STN-DBS is likely to be a safe treatment for PD patients with high risk for anxiety disorders.
1661 – Effects Of a Basic Protocol To Manage Patients With Personality Disorders In The General Hospital
Authors: Gonzalez-Torres M.A. , Bustamante S. , Vivanco E. , Martinez K. , Alvarez de Eulate S. , Fernandez-Rivas A. 
Published: July 2013

IntroductionPatients presenting Personality Disorders and specially Borderline Personality Disorder are often admitted to Psychiatry Units in General Hospitals. Their impulsivity, affective disregulation and difficulties in interpersonal relations complicate the therapeutic atmosphere and cause problematic interactions with staff and other patients. We have developed a basic protocol to manage behavioural problems of those patients in the general hospital.ObjectivesTo study the effect of the protocol on the unit's work. Aims. To know the effect of the protocol on some specific variables related to the admission and specifically the use of mechanical restraint. Methods. Prospectively, we compare data on all patients admitted during 2010 (876 total, 87 PD) before establishing the protocol and all those admitted during 2011 (870 total, 112 PD) when the protocol was in use.ResultsThe proportion of patients with PD who experienced at least one mechanical restraint intervention went down from 43.7% in 2010 to only 2.7% in 2011 (p= 0.000). In the total group, figures also decreased from 17.3% in 2010 to 3.4% in 2011 (p= 0.000).ConclusionsThe use of mechanical restraints with PD patients in General Hospital Psychiatric Units can be drastically reduced using a protocol guiding the staff to better manage behavioural problems of the patients.
1662 – Clozapine Rechallenging Following Neutropenia In The Treatment Of Intellectual Disability And Comorbid Psychotic Symptoms: a Case Report
Authors: Simoni E. , Moretti V. , Pighi M. , Tedeschini E. , Mazzi F. , Ferrari S. 
Published: July 2013

Clozapine has anti-aggressive effects independent of improvement of psychosis and reduce aggression, agitation and selfinjurious behavior. Among individuals with intellectual disabilities (ID) and comorbid psychiatric illness, clozapine is increasingly being prescribed to treat behavioral disturbances.We report a case of clozapine rechallenge after neutropenia in a 30-year-old patient affected by intellectual disability and psychotic disorder with disruptive behavior.After several failed trials of other antipsychotics, the patient required an inpatient stabilization. Clozapine was prescribed to manage his severe set of psychotic symptoms and behavioral disturbances. At baseline the full blood count was normal. The patient responded to clozapine and the dose was rapidly increased until it was 300 mg/day. After ten days, a white blood cell (WBC) count of 3.50 migl/mmc and a neutrophil count of 1.56 migl/mmc were revealed. Clozapine was withdrawn. During the following three months the patient had been treated with several combinations of antipsychotics, mood stabilizers and benzodiazepines, but he continued to exhibit bizarre behavior, severe paranoid delusions, and an inability to conduct activities of daily living. Therefore, after a brief period of washout, clozapine was reinstated (25 mg/day) and it was slowly increased by 25 mg every week until it was 100 mg/day. The patient improved and his WBC count and absolute neutrophil count remained within normal limits. Clozapine might be an effective treatment option for individuals with ID and psychotic disorder whose symptoms are not adequately controlled. Furthermore, we assume that a slow titration might help in preventing neutropenia during clozapine rechallenging.
1670 – Prevalence Of Apathy And Depression In a Population Of Elderly Subjects Using Specific Diagnostic Criteria: Preliminary Results From a Multicenter Cross-sectional Study (adep Study)
Authors: Bensamoun D. , Derreumaux A. , Aguera Ortiz L.F. , Lopez J. , Karsten K. , Dechamps A. , Dachesky D. , Bianchini S. , Robert P. , David R. 
Published: July 2013

IntroductionApathy and depression are the two most frequent neuropsychiatric symptoms in Alzheimer's disease (AD) and related disorders. Whereas neuroimaging studies have shown different neural pathways for these two symptoms, a clinical overlap between apathy and depression is frequently described.ObjectiveTo describe the prevalence of apathy and depression among elderly subjects with or without dementia criteria using specific diagnostic criteria for apathy and depression.MethodSubjects from an ongoing cross-sectional study were recruited in 4 centers (France, Indonesia, Spain, Argentina). Apathy and depression were assessed using the diagnostic criteria for apathy and for depression. Additionally, the apathy and dysphoria domains of the NPI-C (Neuropsychiatric Inventory-Clinician), as well as the 12 domains of the original NPI (Neuropsychiatric Inventory) were assessed.Results431 subjects (mean age=74.6 ± 10.4 ; gender=♂ 29%) were recruited (France=100, Spain=90, Indonesia=182, Argentina=79). Among them, 25% were healthy elderly subjects, 9% had a diagnosis of MCI (Mild Cognitive Impairment), 46% had a diagnosis of dementia (including AD, Lewy body, vascular, mixed and fronto-temporal dementia). In the overall population, the prevalence of apathy and depression were respectively 41% and 25%. More specifically, the prevalence of apathy and depression in the AD sample were 67% and 25%.ConclusionDiagnostic criteria for apathy and depression, as well as the NPI-C, are recent assessment methods in the field of dementia, developed to increase the accuracy of the clinical evaluation of BPSD. It is therefore critical to propose multicenter observational studies comparing these new tools with classical assessment methods.
1672 – Pathological Internet Use Among European Adolescents: Psychopathology And Self-destructive Behaviors
Authors: Durkee T. , Kaess M. , Carli V. , Sarchiapone M. , Wasserman C. , Hoven C. , Wasserman D. ,   SEYLE Consortium
Published: July 2013

AimsTo investigate the association of psychopathology and self-destructive behaviors with maladaptive Internet use (MIU) and pathological Internet use (PIU) among European adolescents.DesignA cross-sectional analysis.SettingThe study was performed within the context of an on-going epidemiological study conducted in Europe entitled Saving and Empowering Young Lives in Europe (SEYLE). Schools were randomly selected in catchment areas across eleven countries: Austria, Estonia, France, Germany, Hungary, Ireland, Israel, Italy, Romania, Slovenia and Spain, with Sweden as the coordinating center.ParticipantsThe study sample comprised 11,357 school-based adolescents (M/F: 4,856/6,501; Mean Age: 14.9).MeasurementsMIU and PIU was measured by the Young's Diagnostic Questionnaire for Internet Addiction (YDQ). Psychopathology was measured using the Beck Depression Inventory-II (BDI-II), Zung Self-Rating Anxiety Scale (Z-SAS) and Strengths and Difficulties Questionnaire (SDQ); self-destructive behaviors were assessed by the Deliberate Self-Harm Inventory (DSHI) and Paykel Suicide Scale (PSS).FindingsMIU and PIU prevalence was 13.4% and 4.2%, respectively; significant gender and country differences were found. A stepwise regression showed that suicidal behavior (RRR=9.8), depression (RRR=5.4), conduct problems (RRR=1.9) and symptoms of ADHD (RRR=1.7) were independently associated with PIU. Anxiety, peer relationship problems and NSSI were not independent factors in the model explaining PIU. Gender and country interactions influenced the association between psychopathology, suicidal behaviors and the YDQ score.ConclusionAmong adolescents, certain forms of psychopathology and self-destructive behaviors appeared to be highly interrelated with MIU and PIU. These associations are influenced by both gender and country.
1673 – Evaluation Of Sleep And Pain In Newly Diagnosed Patients With Generalised Anxiety Disorder (gad): The Espiga Study
Authors: Allgulander C. , Baldwin D.S. , Gastó C. , Pirkola S. , Wittchen H.-U. , Atkinson G. , Haswell H. , Prieto R. 
Published: July 2013

IntroductionIn the general population the 12-month prevalence of GAD is estimated to be about 2%. Higher prevalences have been found in primary care settings, with estimates of well over 6%. The role of sleep problems and pain in GAD remains understudied.ObjectivesTo evaluate the frequency of sleep problems and pain in newly diagnosed GAD patients in 5 European countries.MethodsNon-interventional, cross-sectional survey of 1650 adult patients newly diagnosed with GAD in primary care settings. Assessment included clinical interview rating and self report data.ResultsMean age of the sample was 49.2 years (SD; 14.5). Mean GAD-7 score was 14.8 (SD; 3.1) and the median duration of symptoms was 12.0 months. The proportion with sleep disturbance and pain were 85.9% and 75.9%, respectively. Disturbed sleep had persisted for a median of 9.0 months and was mainly classified as “difficulty in falling asleep” (76.1%) or “nocturnal awakening” (58.8%). The median duration of pain was 6.0 months, and located mainly in the cervical region (47.0%) and upper back/limbs (40.1%). The mean number of days that patients were unable to work because of GAD-related health problems during the preceding 3 month period was 10.8 (95%CI; 9.6-12.0). The proportion of patients that visited the primary care physician and specialist during the preceding 3 months was 93.8% and 40.3%, respectively.ConclusionsSleep problems and pain are extremely frequent characteristics of GAD, contributing to the disability and work productivity profile associated with GAD as well as the patients’ use of health care resources.