bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiemetics: American Society of Clinical Oncology Focused Guideline Update
Authors: Hesketh Paul J. , Bohlke Kari , Lyman Gary H. , Basch Ethan , Chesney Maurice , Clark-Snow Rebecca Anne , Danso Michael A. , Jordan Karin , Somerfield Mark R. , Kris Mark G. 
Published: November 2015

Purpose To update a key recommendation of the American Society of Clinical Oncology antiemetic guideline. This update addresses the use of the oral combination of netupitant (a neurokinin 1 [NK1] receptor antagonist) and palonosetron (a 5-hydroxytryptamine-3 [5-HT3] receptor antagonist) for the prevention of acute and delayed nausea and vomiting in patients receiving chemotherapy. Methods An update committee conducted a targeted systematic literature review and identified two phase III clinical trials and a randomized phase II dose-ranging study. Results In one phase III trial, the oral combination of netupitant and palonosetron was associated with higher complete response rates (no emesis and no rescue medications) compared with palonosetron alone in patients treated with anthracycline plus cyclophosphamide chemotherapy (74% v 67% overall; P = .001). In another phase III trial, the oral combination of netupitant and palonosetron was safe and effective across multiple cycles of moderately or highly emetogenic chemotherapies. In the phase II dose-ranging study, each dose of netupitant (coadministered with palonosetron 0.50 mg) produced higher complete response rates than palonosetron alone among patients receiving cisplatin-based chemotherapy. The highest dose of netupitant (ie, 300 mg) was most effective. Recommendations All patients who receive highly emetogenic chemotherapy regimens (including anthracycline plus cyclophosphamide) should be offered a three-drug combination of an NK1 receptor antagonist, a 5-HT3 receptor antagonist, and dexamethasone. The oral combination of netupitant and palonosetron plus dexamethasone is an additional treatment option in this setting. The remaining recommendations from the 2011 ASCO guideline are unchanged pending a full update. Additional information is available at www.asco.org/guidelines/antiemetics and www.asco.org/guidelineswiki .
Interaction between CHL1 and serotonin receptor 2c regulates signal transduction and behavior in mice
Authors: Kleene Ralf , Chaudhary Harshita , Karl Nicole , Katic Jelena , Kotarska Agnieszka , Guitart Kathrin , Loers Gabriele , Schachner Melitta 
Published: November 2015

ABSTRACT
The serotonergic system plays important roles in multiple functions of the nervous system and its malfunctioning leads to neurological and psychiatric disorders. Here, we show that the cell adhesion molecule close homolog of L1 (CHL1), which has been linked to mental disorders, binds to a peptide stretch in the third intracellular loop of the serotonin 2c (5-HT2c) receptor through its intracellular domain. Moreover, we provide evidence that CHL1 deficiency in mice leads to 5-HT2c-receptor-related reduction in locomotor activity and reactivity to novelty, and that CHL1 regulates signaling pathways triggered by constitutively active isoforms of the 5-HT2c receptor. Furthermore, we found that the 5-HT2c receptor and CHL1 colocalize in striatal and hippocampal GABAergic neurons, and that 5-HT2c receptor phosphorylation and its association with phosphatase and tensin homolog (PTEN) and β-arrestin 2 is regulated by CHL1. Our results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.
CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly
Authors: Shono Nobuaki , Ohzeki Jun-ichirou , Otake Koichiro , Martins Nuno M. C. , Nagase Takahiro , Kimura Hiroshi , Larionov Vladimir , Earnshaw William C. , Masumoto Hiroshi 
Published: November 2015

ABSTRACT
Although it is generally accepted that chromatin containing the histone H3 variant CENP-A is an epigenetic mark maintaining centromere identity, the pathways leading to the formation and maintenance of centromere chromatin remain unclear. We previously generated human artificial chromosomes (HACs) whose centromeres contain a synthetic alpha-satellite (alphoid) DNA array containing the tetracycline operator (alphoidtetO). We also obtained cell lines bearing the alphoidtetO array at ectopic integration sites on chromosomal arms. Here, we have examined the regulation of CENP-A assembly at centromeres as well as de novo assembly on the ectopic arrays by tethering tetracycline repressor (tetR) fusions of substantial centromeric factors and chromatin modifiers. This analysis revealed four classes of factors that influence CENP-A assembly. Interestingly, many kinetochore structural components induced de novo CENP-A assembly at the ectopic site. We showed that these components work by recruiting CENP-C and subsequently recruiting M18BP1. Furthermore, we found that CENP-I can also recruit M18BP1 and, as a consequence, enhances M18BP1 assembly on centromeres in the downstream of CENP-C. Thus, we suggest that CENP-C and CENP-I are key factors connecting kinetochore to CENP-A assembly.
Foreign Officials Bribery Control: Legal Ground, Main Terms, State Policy
Authors: Донцова  , Dontsova Lyudmila , Артёменко  , Artemenko I. 
Published: November 2015

The article reviews main terms and legal grounds for setting up a foreign officials’ bribery control system, which
for the past few years has been the foremost state goal not only in Russia but also in many countries around the globe.
Does pathological fracture affect the rate of local recurrence in patients with a giant cell tumour of bone?
Authors: Salunke A. A. , Chen Y. , Chen X. , Tan J. H. , Singh G. , Tai B. C. , Khin L. W. , Puhaindran M. E. 
Published: November 2015

We investigated whether the presence of a pathological fracture increased the risk of local recurrence in patients with a giant cell tumour (GCT) of bone. We also assessed if curettage is still an appropriate form of treatment in the presence of a pathological fracture. We conducted a comprehensive review and meta-analysis of papers which reported outcomes in patients with a GCT with and without a pathological fracture at presentation. We computed the odds ratio (OR) of local recurrence in those with and without a pathological fracture. We selected 19 eligible papers for final analysis. This included 3215 patients, of whom 580 (18.0%) had a pathological fracture. The pooled OR for local recurrence between patients with and without a pathological fracture was 1.05 (95% confidence interval (CI) 0.66 to 1.67, p = 0.854). Amongst the subgroup of patients who were treated with curettage, the pooled OR for local recurrence was 1.23 (95% CI 0.75 to 2.01, p = 0.417). A post hoc sample size calculation showed adequate power for both comparisons. There is no difference in local recurrence rates between patients who have a GCT of bone with and without a pathological fracture at the time of presentation. The presence of a pathological fracture should not preclude the decision to perform curettage as carefully selected patients who undergo curettage can have similar outcomes in terms of local recurrence to those without such a fracture. Cite this article: Bone Joint J 2015;97-B:1566–71.
An alternative technique for stabilisation of the carpometacarpal joint of the thumb after dislocation or subluxation
Authors: Zhang X. , Shao X. , Huang W. , Zhu H. , Yu Y. 
Published: November 2015

We report a new surgical technique for the treatment of traumatic dislocation of the carpometacarpal (CMC) joint of the thumb. This is a tenodesis which uses part of the flexor carpi radialis. Between January 2010 and August 2013, 13 patients with traumatic instability of the CMC joint of the thumb were treated using this technique. The mean time interval between injury and ligament reconstruction was 13 days (0 to 42). The mean age of the patients at surgery was 38 years: all were male. At a mean final follow-up of 26 months (24 to 29), no patient experienced any residual instability. The mean total palmar abduction of the CMC joint of the thumb was 61° and the mean radial abduction 65° The mean measurements for the uninjured hand were 66° (60° to 73°) and 68° (60° to 75°), respectively. The mean Kapandji thumb opposition score was 8.5° (8° to 9°). The mean pinch and grip strengths of the hand were 6.7 kg (3.4 to 8.2) and 40 kg (25 to 49), respectively. The mean Disabilities of the Arm, Shoulder, and Hand questionnaire score was 3 (1 to 6). Based on the Smith and Cooney score, we obtained a mean score of 85 (75 to 95), which included four excellent, seven good, and two fair results. Our technique offers an alternative method of treating traumatic dislocation of the CMC joint of the thumb: it produces a stable joint and acceptable hand function. Cite this article: Bone Joint J 2015;97-B:1533–8.
The rates of wear of X3 highly cross-linked polyethylene at five years when coupled with a 36 mm diameter ceramic femoral head in young patients
Authors: Selvarajah E. , Hooper G. , Grabowski K. , Frampton C. , Woodfield T. B. F. , Inglis G. 
Published: November 2015

Polyethylene wear debris can cause osteolysis and the failure of total hip arthroplasty. We present the five-year wear rates of a highly cross-linked polyethylene (X3) bearing surface when used in conjunction with a 36 mm ceramic femoral head.This was a prospective study of a cohort of 100 THAs in 93 patients. Pain and activity scores were measured pre- and post-operatively. Femoral head penetration was measured at two months, one year, two years and at five years using validated edge-detecting software (PolyWare Auto).At a mean of 5.08 years (3.93 to 6.01), 85 hips in 78 patients were available for study. The mean age of these patients was 59.08 years (42 to 73, the mean age of males (n = 34) was 59.15 years, and females (n = 44) was 59.02 years). All patients had significant improvement in their functional scores (p < 0.001). The steady state two-dimensional linear wear rate was 0.109 mm/year. The steady state volumetric wear rate was 29.61 mm3/year. No significant correlation was found between rate of wear and age (p = 0.34), acetabular component size (p = 0.12) or clinical score (p = 0.74).Our study shows low steady state wear rates at five years in X3 highly cross-linked polyethylene in conjunction with a 36 mm ceramic femoral head. The linear wear rate was almost identical to the osteolysis threshold of 0.1 mm/year recommended in the literature.Cite this article: Bone Joint J 2015;97-B:1470–4.
Comparison between percutaneous fluoroscopic-guided and conventional open pedicle screw placement techniques for the thoracic spine
Authors: Kwan M. K. , Chiu C. K. , Lee C. K. , Chan C. Y. W. 
Published: November 2015

Percutaneous placement of pedicle screws is a well-established technique, however, no studies have compared percutaneous and open placement of screws in the thoracic spine. The aim of this cadaveric study was to compare the accuracy and safety of these techniques at the thoracic spinal level. A total of 288 screws were inserted in 16 (eight cadavers, 144 screws in percutaneous and eight cadavers, 144 screws in open). Pedicle perforations and fractures were documented subsequent to wide laminectomy followed by skeletalisation of the vertebrae. The perforations were classified as grade 0: no perforation, grade 1: < 2 mm perforation, grade 2: 2 mm to 4 mm perforation and grade 3: > 4 mm perforation. In the percutaneous group, the perforation rate was 11.1% with 15 (10.4%) grade 1 and one (0.7%) grade 2 perforations. In the open group, the perforation rate was 8.3% (12 screws) and all were grade 1. This difference was not significant (p = 0.45). There were 19 (13.2%) pedicle fractures in the percutaneous group and 21 (14.6%) in the open group (p = 0.73). In summary, the safety of percutaneous fluoroscopy-guided pedicle screw placement in the thoracic spine between T4 and T12 is similar to that of the conventional open technique.Cite this article: Bone Joint J 2015;97-B:1555–61.
Oxinium modular femoral heads do not reduce polyethylene wear in cemented total hip arthroplasty at five years
Authors: Jonsson B. A. , Kadar T. , Havelin L. I. , Haugan K. , Espehaug B. , Indrekvam K. , Furnes O. , Hallan G. 
Published: November 2015

We report the five-year outcome of a randomised controlled trial which used radiostereometric analysis (RSA) to assess the influence of surface oxidised zirconium (OxZr, Oxinium) on polyethylene wear in vivo.A total of 120 patients, 85 women and 35 men with a mean age of 70 years (59 to 80) who were scheduled for primary cemented total hip arthroplasty were randomly allocated to four study groups. Patients were blinded to their group assignment and received either a conventional polyethylene (CPE) or a highly cross-linked (HXL) acetabular component of identical design. On the femoral side patients received a 28 mm head made of either cobalt-chromium (CoCr) or OxZr.The proximal head penetration (wear) was measured with repeated RSA examinations over five years. Clinical outcome was measured using the Harris hip score.There was no difference in polyethylene wear between the two head materials when used with either of the two types of acetabular component (p = 0.3 to 0.6). When comparing the two types of polyethylene there was a significant difference in favour of HXLPE, regardless of the head material used (p < 0.001).In conclusion, we found no advantage of OxZr over CoCr in terms of polyethylene wear after five years of follow-up. Our findings do not support laboratory results which have shown a reduced rate of wear with OxZr. They do however add to the evidence on the better resistance to wear of HXLPE over CPE.Cite this article: Bone Joint J 2015;97-B:1463–9.
Putting the baby back in the bathwater
Authors: Gandhi R. , Perruccio A. V. , Kakar S. , Haddad F. S. 
Published: November 2015

Recently, several high impact randomised controlled trials have been published suggesting no greater benefit from orthopaedic surgery over conservative treatment, or limited surgical intervention. These studies can have profound effects on clinical practice, leading to the abandonment of previously widely-used operations. How do surgeons who believe these operations are beneficial over conservative treatment rationalise these findings, and justify their use with hospital administrators and health care funders who require evidence for the value and efficacy of surgical treatment? Cite this article: Bone Joint J 2015;97-B:1456–7.
Protocol for Heat Treating Black Walnut Wood Infested with Walnut Twig Beetle
Authors: Mackes Kurt , Costanzo Tara , Coleman Rocky , Eckhoff Mike , Vaughan Damon 
Published: November 2015

Abstract
Black walnut (Juglans nigra) is one of the most important tree species in the United States for producing lumber and other forest products. However, a recent outbreak of thousand cankers disease vectored by the walnut twig beetle (Pityophthorus juglandis) threatens the population of black walnut in the United States. Infected walnut trees are typically removed to prevent spread of the vector, resulting in large quantities of potential sawlogs that must be sanitized. The objective of this study was to identify the temperature and time combination necessary to heat treat infested materials to 100% beetle mortality. Testing was done on infested sample blocks that contained sapwood and bark. The specimens were heated to various temperatures and examined, both through emergence chambers and destructive sampling, for the presence of P. juglandis at any life stage. Results of the study indicate that heat treating black walnut products to 50.1°C at a depth of 3.8 cm (1.5 in.) for 30 minutes will result in 100 percent beetle mortality. As a side product, this study also produced 3,000 board feet of rough-cut lumber. These boards were heat treated and sold, following the protocol developed in this study. This study demonstrates that wood from black walnut trees infected with thousand cankers disease can be effectively heat sterilized and utilized, reducing the need to chip, landfill, or otherwise dispose of the material without economic return.
Aboveground Decay Resistance of Selected Canadian Softwoods at Four Test Sites after 10 Years of Exposure
Authors: Morris Paul Ian , Laks Peter , Larkin Glenn , Ingram Janet K. , Stirling Rod 
Published: November 2015

Abstract
Aboveground field performance data are needed to help users select appropriate materials, assist in the development of evidence-based codes and standards, and support the development of new export markets. A review of the literature in the early 2000s revealed that there was very little hard data on the performance of North American naturally durable wood species, particularly for aboveground applications. Field tests of six Canadian wood species reputed to have moderate to high natural durability were therefore installed in test out-of-ground contact in the autumn of 2004 and spring of 2005 at two test sites in Canada and two in the United States. Decay results are reported after 10 years. The test site with the fastest aboveground decay rate was in Hawaii. Above ground, yellow cedar (Callitropsis nootkatensis) and western red cedar (Thuja plicata) were the most consistently durable at all four test sites. However, it would not have been possible to predict the relative performance of naturally durable species in one climate and location from their relative performance in another climate and location. The presence of sapwood was associated with more severe decay, although it was unclear whether the presence of sapwood increased the risk of decay in the adjacent heartwood. There was no substantial difference between decay in old-growth and second-growth samples above ground. The presence of a coating applied to decking had some protective effect against decay at the less aggressive test sites.
Perbandingan jumlah bak budidaya cacing sutra (tubificidae) dengan memanfaatkan limbah budidaya ikan lele (clarias sp) sistem intensif terhadap kualitas air ikan lele dan produksi cacing sutra
Authors: Supriyono Eddy , Pardiansyah Dedi , Sriwisuda Putri Diana , Djokosetianto Daniel 
Published: November 2015

Abstract. This objective of the research was to compare the number of blood worm production using catfish cultivation waste, while the water from catfish cultivation flowed to blood worm cultivation with recirculate system. This research were used 3 treatments and 2 replications, the treatment was 2, 4 and 6 containers of blood worm. The results showed that the highest water quality and biomass was 6 containers treatment with 1.4 kg m-2 weight gain.Keywords: Catfish; silk worm; waste intensive farming. Abstrak. Penelitian ini bertujuan untuk menganalisa perbandingan jumlah bak budidaya cacing sutra dengan memanfaatkan limbah budidaya lele sistem intensif terhadap kualitas air ikan lele dan produksi cacing sutra, dimana air dari media budidaya ikan dialirkan ke media pemeliharaan cacing sutra dengan sistem resirkulasi. Penelitian ini menggunakan rancangan acak lengkap dengan 3 perlakuan dan 2 ulangan, perlakuan yaitu Pemanfaatan 2 bak, 4 bak dan 6 bak cacing sutra. Hasil penelitian menunjukkan bahwa perbaikan kualitas air budidaya lele dan produksi bobot biomassa tertinggi pada perlakuan 6 bak dengan pertumbuhan berat sebesar 1,4 Kg m-2.Kata kunci: ikan lele; cacing sutra; limbah lele
The Great, the Little, and the Authoritative Tradition in Magic of the Ancient World
Authors: Frankfurter David 
Published: November 2015

Abstract This paper develops “magic” as a category useful for describing local forms of an institutional or “great” tradition (using the classic terminology of Robert Redfield): ritual acts, symbols and materials, and constructions of local ritual expertise to interpret elements of a great tradition. Ultimately the paper contributes to the historical relationship between (centralized expressions of) “religion” and “magic” (as some quality or dimension of ritual).
Sealing the Demons, Once and For All: The Ring of Solomon, the Cross of Christ, and the Power of Biblical Kingship
Authors: Boustan Raʿanan , Beshay Michael 
Published: November 2015

Abstract This paper traces the historical development of the tradition that King Solomon made use of a signet-ring to marshal the demons as a labor-force for the construction of the Jerusalem Temple and analyzes the shifting ritual uses to which this tradition was put.We argue that this tradition, which is most fully articulated in the Testament of Solomon, is a Christian innovation of the third and fourth centuries rather than a venerable Jewish tradition with roots in the Second Temple period. This branch of the Solomon tradition first emerged within the context of internal Christian debates of the third century concerning proper baptismal practice, where the power of baptism to provide protection from the demons was linked to debates concerning the efficacy of Solomon’s act of sealing the demons in the temple. In the post-Constantinian period, the ring of Solomon was venerated by pilgrims to Jerusalem as a “relic” of Israelite kingship alongside the True Cross. Like certain strands of the Testament of Solomon literature, the pilgrimage practices performed at this potent site figure Christ’s victory on the cross as the fulfillment-once and for all-of Solomon’s only provisional mastery over the demons. In this context, Solomon’s ring gave concrete expression to Christian claims on the Old Testament past, while also mediating between imperial and ecclesiastical power.
Ancient Wilderness Mythologies—The Case of Space and Religious Identity Formation in the Gospel of Matthew
Authors: Feldt Laura 
Published: November 2015

Abstract This article discusses the nexus of religion and wilderness by analyzing the reception and transformation of wilderness mythology from The Hebrew Bible in early Christian literature. It focuses on the impact of the Torah wilderness space on religious identity formation in the gospel of Matthew. Drawing on theories of social space and narrativity, the article compares the Torah wilderness space with that of Matthew and argues that wilderness mythology is of central importance for how the gospel of Matthew becomes effective as a religious text, which strives to form religious identity and practice.
The Self-sacrifice of Menoeceus in Euripides’ Phoenissae, II Maccabees and Statius’ Thebaid
Authors: Bremmer Jan N. 
Published: November 2015

Abstract In his Phoenissae Euripides introduced a unique case of male self-sacrifice before battle instead of the traditional virgin sacrifice. Its appropriation by II Maccabees and Statius as well as by its important resonance until the end of antiquity demonstrates the success of this innovation. In the male-dominated world of the Greeks and Romans, a male self-sacrifice clearly was more attractive to use than that of a virgin. The example of Menoeceus shows that gender does play a role even in the transmission of myths and mythical motives.