bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reactions of Propargyl Compounds Containing a Cyclobutyl Group Induced by a Ruthenium Complex
Authors: Wang Yung‐Ching , Lin Ying‐Chih , Liu Yi‐Hung 
Published: August 2012

AbstractReactions of [Ru]Cl ([Ru]={Cp(PPh3)2Ru}; Cp=cyclopentadienyl) with three alkynyl compounds, 1, 5, and 8, each containing a cyclobutyl group, are explored. For 1, the reaction gives the vinylidene complex 2, with a cyclobutylidene group, through dehydration at CδH and CγOH. With an additional methylene group, compound 5 reacts with [Ru]Cl to afford the cyclic oxacarbene complex 6. The reaction proceeds via a vinylidene intermediate followed by an intramolecular cyclization reaction through nucleophilic addition of the hydroxy group onto Cα of the vinylidene ligand. Deprotonation of 2 with NaOMe produces the acetylide complex 3 and alkylations of 3 by allyl iodide, methyl iodide, and ethyl iodoacetate generate 4 a–c, respectively, each with a stable cyclobutyl group. Dehydration of 1 is catalyzed by the cationic ruthenium acetonitrile complex at 70 °C to form the 1,3‐enyne 7. The epoxidation reaction of the double bond of 7 yields oxirane 8. Ring expansion of the cyclobutyl group of 8 is readily induced by the acidic salt NH4PF6 to afford the 2‐ethynyl‐substituted cyclopentanone 9. The same ring expansion is also seen in the reaction of [Ru]Cl with 8 in CH2Cl2, affording the vinylidene complex 10, which can also be obtained from 9 and [Ru]Cl. However, in MeOH, the same reaction of [Ru]Cl with 8 affords the bicyclic oxacarbene complex 12 a through an additional cyclization reaction. Transformation of 10 into 12 a is readily achieved in MeOH/HBF4, but, in MeOH alone, acetylide complex 11 is produced from 10. In the absence of MeOH, cyclization of 10, induced by HBF4, is followed by fluorination to afford complex 13. Crystal structures of 6 and 12 a′ were determined by single‐crystal diffraction analysis.
Reliable Dissipative Control for Singular Markovian Systems
Authors: Feng Zhiguang , Lam James 
Published: August 2012

AbstractIn this paper, the problem of reliable dissipative control is investigated for a continuous‐time singular Markovian system with actuator failure. First, a sufficient condition is established in terms of linear matrix inequalities (LMIs), which guarantees a singular Markovian system to be stochastically admissible and strictly (Q,S,R)‐dissipative. Based on this criterion, a state feedback controller design method is given in terms of strict LMIs. Moreover, the dissipative control results include the results of H
∞ control and passive control as special cases. The effectiveness of the controller designed method in this paper is illustrated by a numerical example.
Age of onset and effect size in genome‐wide association studies
Authors: Agopian A.J. , Eastcott Lisa M. , Mitchell Laura E. 
Published: August 2012

AbstractBACKGROUNDGenome‐wide association studies (GWAS) have identified many susceptibility loci for complex traits, but have not identified the majority of the genetic contribution to common diseases. We explored whether the magnitude of associations detected in GWAS and, therefore, the likelihood of detecting a significant association for a given sample size, is generally greater for childhood‐onset traits (e.g., birth defects) than for traits with onset in adulthood.METHODSData were obtained from the National Human Genome Research Institute Catalog of Published GWAS. Traits were categorized as having an average age of onset in childhood (<18 years, n = 15 traits), early adulthood (18–54 years, n = 32 traits), or late adulthood (≥55 years, n = 31 traits). The relationship between age of onset category and the magnitude of significant associations detected by GWAS was assessed using logistic regression.RESULTSAssociations characterized by an odds ratio (OR) ≥ 1.5 were significantly more common for GWAS of childhood traits than for late adulthood‐onset traits after adjustment for several covariates (adjusted OR, 2.55; 95% confidence interval, 1.37–4.73). Results in subgroup analyses using more stringent inclusion criteria (based on sample size, effect size, p value threshold for inclusion, and novel variant‐trait associations) were similar.CONCLUSIONSThese findings suggest that, on average, marker‐trait associations detected in GWAS for traits with young onset may have a larger magnitude of effect than those for traits with adult onset. Therefore, GWAS for young‐onset traits, such as birth defects, may be more likely than those for adult‐onset traits to identify major genetic risk factors. Birth Defects Research (Part A) 2012. © 2012 Wiley Periodicals, Inc.
Control of osteogenesis by the canonical Wnt and BMP pathways in vivo
Authors: Marcellini Sylvain , Henriquez Juan Pablo , Bertin Ariana 
Published: August 2012

AbstractAlthough many regulators of skeletogenesis have been functionally characterized, one current challenge is to integrate this information into regulatory networks. Here, we discuss how the canonical Wnt and Smad‐dependent BMP pathways interact together and play antagonistic or cooperative roles at different steps of osteogenesis, in the context of the developing vertebrate embryo. Early on, BMP signaling specifies multipotent mesenchymal cells into osteochondroprogenitors. In turn, the function of Wnt signaling is to drive these osteochondroprogenitors towards an osteoblastic fate. Subsequently, both pathways promote osteoblast differentiation, albeit with notable mechanistic differences. In osteocytes, the ultimate stage of osteogenic differentiation, the Wnt and BMP pathways exert opposite effects on the control of bone resorption by osteoclasts. We describe how the dynamic molecular wiring of the canonical Wnt and Smad‐dependent BMP signaling into the skeletal cell genetic programme is critical for the generation of bone‐specific cell types during development.
Surface anatomy of the pulmonary fissures determined by high‐resolution computed tomography
Authors: Heřmanová Zuzana , Čtvrtlík Filip , Heřman Miroslav 
Published: August 2012

AbstractThe aim of our study was to describe the surface anatomy of the interlobar fissures using volumetric thin‐section high‐resolution computed tomography (HRCT). Retrospective assessment of HRCT examinations of 250 patients was performed. The localization of the oblique fissures was marked at three sites: posteriorly at its most superior medial limit, laterally in the midaxillary line, and inferiorly at the junction of the middle and lateral thirds of the hemithorax; posteriorly and laterally, this was to the nearest rib whilst inferiorly the position was described in relation to the diaphragm or chest wall. The localization of the horizontal fissure was marked anteriorly in relation to the nearest rib (or costal cartilage) and posteriorly where it intersected with the oblique fissure (superior, middle, or inferior third). Shapes of the fissures and differences between inspiration and expiration were also documented. Descriptive statistics were used to report the most frequent positions. The most frequent localization of the oblique fissure on the left side was posteriorly at the fourth rib (45%), laterally at the sixth rib (52%), and inferiorly in the anterior third of the hemidiaphragm (60%). The right oblique fissure was located posteriorly at the fifth rib (50%), laterally at the sixth rib (50%), and inferiorly in the anterior third of the hemidiaphragm (71%). The horizontal fissure most commonly originated in the middle third of the oblique fissure (61%) and met the anterior thoracic wall at the level of the fourth rib (51%). The most frequent shape of the left oblique fissure was linear (78%), whereas S‐shaped and linear configurations (28% each) were most frequent on the right. No difference was found in the surface markings of the fissures between inspiration and expiration in 90% of cases. The considerable individual variation in the position and shape of the interlobar fissures helps to explain the variable descriptions of their surface anatomy in the literature. Clin. Anat. 25:835–843, 2012. © 2012 Wiley Periodicals, Inc.
Evidence to support that adventitial cysts, analogous to intraneural ganglion cysts, are also joint‐connected
Authors: Spinner Robert J. , Desy Nicholas M. , Agarwal Gautum , Pawlina Wojciech , Kalra Manju , Amrami Kimberly K. 
Published: August 2012

AbstractCystic adventitial disease (CAD) is a rare condition in which cyst is found within a vessel, typically producing symptoms of vascular compromise. Most commonly located in the popliteal artery near the knee, it has been reported in arteries and veins throughout the body. Its pathogenesis has been poorly understood and various surgical approaches have been recommended. We extrapolated some recent information about a similar condition, intraneural ganglion cyst affecting the deep fibular (peroneal) nerve, to the prototype, CAD of the popliteal artery. In intraneural ganglion cysts affecting the deep fibular nerve we have shown that an articular (neural) branch is the conduit between the superior tibiofibular joint and the main parent nerve for which epineurial dissection of joint fluid can occur. We hypothesized that the same principles would apply to CAD and that an articular (vascular) branch would be the conduit from the knee joint leading to dissection to the main parent vessel. We reviewed five patients with CAD of the popliteal artery in whom MRIs were available: two treated by the primary author well familiar with the proposed articular theory, and three treated by others at our institution, less familiar with it. We then reviewed the literature critically to assess for additional evidence to support our articular (synovial) theory and an anatomic explanation. In the two cases treated by the primary author a joint connection was identified on high resolution MRI prospectively and intraoperatively through the middle genicular artery (MGA); postoperatively in these cases there was no recurrence. In the other three cases, a joint connection was not identified on imaging or at operation. Reinterpretation of these cases revealed a joint connection through the MGA in the one patient who had preoperative imaging and subclinical persistence/recurrence in the two patients who underwent postoperative MRIs done for other reasons. Our review of the literature and imaging studies revealed unrecognized joint connections in CAD to the knee and other joints as well as evidence that the MGA is the conduit in cases of CAD of the popliteal artery. We believe that adventitial cysts originate in neighboring joints and dissect within articular (vascular) branches. In our opinion, the unifying articular theory and the principles introduced for intraneural ganglion cysts apply equally to common and rare sites of adventitial cysts. Clin. Anat., 2013. © 2012 Wiley Periodicals, Inc.
The Benefits and Challenges of Training Child Protection Social Workers in Father Engagement
Authors: Maxwell Nina , Scourfield Jonathan , Holland Sally , Featherstone Brid , Lee Jacquie 
Published: August 2012

It is widely recognised that, in a child protection context, practitioners tend to focus on working with mothers more than fathers. This may undermine risk management and limit the resources available for the care of children. This paper discusses the process of developing and running a training intervention for child protection social workers, designed to improve father engagement (with ‘fathers’ defined inclusively). A short course was provided, consisting of one day of awareness‐raising about the importance of work with fathers and one day of motivational interviewing skills training. The emphasis in the paper is on insights from the qualitative elements of the mixed‐method process evaluation, namely, observation and pre‐ and post‐course interviews. In particular, there is discussion of the potential benefits and challenges of this kind of training, with consideration given to the general issue of father engagement and more specifically the potential for using motivational interviewing in child protection practice. Copyright © 2012 John Wiley & Sons, Ltd.‘The process of developing and running a training intervention for child protection social workers’Key Practitioner Messages

The pilot of the Cardiff University Fathers and Child Protection course resulted in improved engagement of fathers, according to social workers self‐report.
Motivational interviewing has potential for developing practitioners' skills in working with fathers when children are at risk.
There are some inherent challenges in attempting to improve the engagement of fathers in a child protection context.
ChemInform Abstract: Three Alkali‐Metal—Gold—Gallium Systems. Ternary Tunnel Structures and Some Problems with Poorly Ordered Cations.
Authors: Smetana Volodymyr , Miller Gordon J. , Corbett John D. 
Published: August 2012

AbstractSix new compounds, Na0.56Au2Ga2 (I), Rb0.56Au2Ga2 (II), Cs0.54Au2Ga2 (III), RbAu3Ga2 (IV), CsAu3Ga2 (V), and Na13Au41.2Ga30.3 (VI) are synthesized from the elements (Ta tubes, 500 °C for 12 h and 350 °C for 48—96 h) and characterized by single crystal XRD and TB‐LMTO‐ASA calculations.
ChemInform Abstract: Enhanced High‐Temperature Thermoelectric Performance of Yb14‐xCaxMnSb11.
Authors: Uvarov Catherine A. , Ortega‐Alvarez Francisco , Kauzlarich Susan M. 
Published: August 2012

AbstractCrystals of Yb14‐xCaxMnSb11 (x = 2, 4, 6, 8) solid solutions are prepared by reaction of the elements in a Sn flux (excess Mn, alumina crucible sealed in a quartz tube, 1000 °C).
ChemInform Abstract: Mixed‐Valence Uranium Germanate and Silicate: Csx(UVO)(UIV/VO)2 (Ge2O7)2 (x = 3.18) and Cs4(UVO)(UIV/VO)2 (Si2O7)2.
Authors: Chen Chun‐Liang , Nguyen Quang Bac , Chen Chih‐Shan , Lii Kwang‐Hwa 
Published: August 2012

AbstractCs3.18(U3O3) (Ge2O7)2 (I) is hydrothermally synthesized from an aqueous mixture of UO3, Cs(OH), GeO2, and Al in a molar ratio of Cs:U:Ge:Al = 10:1:8:0.5 (autoclave, 165 MPa, 600 °C, 2 d, 62% yield).
ChemInform Abstract: Simple Proline Derivatives as Recoverable Catalysts for the Large‐Scale Stoichiometric Aldol Reactions.
Authors: Li Shi , Wu Chuanlong , Long Xiaoqin , Fu Xiangkai , Chen Guodong , Liu Zhijian 
Published: August 2012

AbstractThe catalyst can be recovered from the aqueous phase and used in seven runs with only a slight loss in enantioselectivity.
ChemInform Abstract: Role of Quaternary Ammonium Salts as New Additives in the Enantioselective Organocatalytic β‐Benzylation of Enals.
Authors: Duce Sara , Mateo Alvaro , Alonso Ines , Garcia Ruano Jose Luis , Cid M. Belen 
Published: August 2012

AbstractThe ammonium salt supports the formation and stabilization of the iminium intermediate and, additionally, activates the nucleophile as an enolate.
ChemInform Abstract: Visible Light Photocatalysis of Intramolecular Radical Cation Diels—Alder Cycloadditions.
Authors: Lin Shishi , Padilla Christian E. , Ischay Michael A. , Yoon Tehshik P. 
Published: August 2012

AbstractActivation by irradiation with a 23W household light bulb offers an operationally simple method to construct polycyclic frameworks via intramolecular Diels—Alder reaction.
ChemInform Abstract: A Convenient Approach to β‐Heteroarylated (C—N Bond) Ketones from Cs2CO3 Promoted Reaction Between Propargyl Alcohols and Nitrogen‐Heterocycles.
Authors: Bhanuchandra M. , Kuram Malleswara Rao , Sahoo Akhila K. 
Published: August 2012

AbstractBase‐induced redox‐isomerization of easily accessible propargyl alcohols followed by conjugate addition of NH heteroarenes gives a series of β‐heteroarylated ketones in one step.
ChemInform Abstract: Synthesis of Oxacyclic Dienes via Ring‐Closing Enyne Metathesis: Difference in Construction of Eight‐Membered Rings.
Authors: Zhang Lin‐Lin , Zhang Wen‐Zhen , Ren Xiang , Tan Xin‐Yan , Lu Xiao‐Bing 
Published: August 2012

AbstractThe process can be applied to the construction of oxacyclic dienes with different ring size and extended to the preparation of eight‐membered N‐heterocycles.
ChemInform Abstract: Direct‐Type Aldol Reactions of Fluorenylidene‐Protected/Activated Glycine Esters with Aldehydes for the Synthesis of β‐Hydroxy‐α‐amino Acid Derivatives.
Authors: Rahmani Raphael , Matsumoto Masatoshi , Yamashita Yasuhiro , Kobayashi Shu 
Published: August 2012

AbstractAldol reaction of glycine Schiff base (I) with various aliphatic aldehydes provides the desired aldol products with high diastereoselectivities.
ChemInform Abstract: A Reusable TNF‐Tagged Chiral Bis(oxazoline)—Copper Catalyst for Diels—Alder Transformations.
Authors: Didier Dorian , Schulz Emmanuelle 
Published: August 2012

AbstractBOA is applied to Diels—Alder reactions between N‐acyloxazolidinones and cyclopentadiene to give bicyclic products (III) as major diastereomers.
ChemInform Abstract: Highly Enantioselective Synthesis of Chiral Allenes by Sequential Creation of Stereogenic Center and Chirality Transfer in a Single Pot Operation.
Authors: Periasamy Mariappan , Sanjeevakumar Nalluri , Dalai Manasi , Gurubrahamam Ramani , Reddy Polimera Obula 
Published: August 2012

AbstractUnder these conditions, a wide range of chiral allenes is available.
ChemInform Abstract: Regioselective C—S Bond Formation Accomplished by Copper‐Catalyzed Regioselective C—F Substitution of Perfluoroarenes with Aryl Thioacetates or Benzyl Thioacetate.
Authors: Zhou Qizhong , Zhang Bin , Du Tieqi , Gu Haining , Jiang Huajiang , Chen Rener 
Published: August 2012

AbstractThe method shows good regioselectivity and provides a useful and operationally simple access to polyfluoroaryl thioethers.
ChemInform Abstract: DDQ‐Mediated Direct Oxidative Coupling of Amides with Benzylic and Allylic sp3 C—H Bonds under Metal‐Free Conditions.
Authors: Ramesh D. , Ramulu U. , Mukkanti K. , Venkateswarlu Y. 
Published: August 2012

AbstractBenzylic and allylic substrates react highly efficient to produce the corresponding amidation products with moderate to good yield.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Dimerization of Styrenes to 1,5‐Diarylpent‐1‐en‐3‐ones.
Authors: Wu Xiao‐Feng , Neumann Helfried , Beller Matthias 
Published: August 2012

AbstractThe present new method is the first general procedure for the carbonylative dimerization of aromatic olefins.
ChemInform Abstract: Microwave‐Assisted Regiospecific Synthesis of Pseudohalohydrin Esters.
Authors: El Khatib Mirna , Elagawany Mohamed , Todadze Ekaterina , Khelashvili Levan , El‐Feky Said A. , Katritzky Alan R. 
Published: August 2012

AbstractThe reaction of N‐acylbenzotriazoles with epoxides provides products which constitute halohydrin ester surrogates.
ChemInform Abstract: Substrate‐Controlled and Highly Stereoselective Synthesis of 2‐Aminobut‐2‐ene‐1,4‐diones.
Authors: Deng Cong , Yang Yan , Gao Meng , Zhu Yan‐Ping , Wu An‐Xin , Ma Jun‐Rui , Yin Guo‐Dong 
Published: August 2012

AbstractMethylthio‐substituted enediones are applied as mixtures of (E)/(Z)‐isomers in the optimized reaction with primary or secondary amines.
ChemInform Abstract: Mizoroki—Heck and Sonogashira Cross‐Couplings Catalyzed by CNC Palladium Pincer Complexes in Organic and Aqueous Media.
Authors: SanMartin Raul , Ines Blanca , Moure Maria Jesus , Herrero Maria Teresa , Dominguez Esther 
Published: August 2012

AbstractThe Pd pincer complex is successfully applied to the title reactions.
ChemInform Abstract: Synthesis of Tetrahydroanthracen‐9‐ones by the Domino Aldol Condensation/Diels—Alder Cycloaddition.
Authors: Chang Meng‐Yang , Wu Ming‐Hao 
Published: August 2012

AbstractSequential NaOH‐mediated aldol condensation of allylacetophenones with cinnamaldehyde, intramolecular Diels—Alder reaction, and double bond migration allows the synthesis of the biologically interesting title compounds in a one‐pot manner.
ChemInform Abstract: Copper(II) Triflate Catalyzed Amination and Aziridination of 2‐Alkyl Substituted 1,3‐Dicarbonyl Compounds.
Authors: Ton Thi My Uyen , Tejo Ciputra , Tiong Diane Ling Ying , Chan Philip Wai Hong 
Published: August 2012

AbstractA slight modification in the reaction conditions allows for selective aziridination or amination of the title compounds.
ChemInform Abstract: Organocatalytic Asymmetric Synthesis of 1,2,4‐Trisubstituted Azetidines by Reductive Cyclization of Aza‐Michael Adducts of Enones.
Authors: Kapoor Ritu , Chawla Ruchi , Singh Santosh , Yadav Lal Dhar S. 
Published: August 2012

AbstractA one‐pot two‐step sequence involving aza‐Michael addition of phosphoramidates to α,β‐unsaturated ketones is catalyzed by chiral primary amine salt (I).
ChemInform Abstract: Efficient Synthesis of the Versatile Phthalide Building Blocks, 5,6‐Diaminoisobenzofuran‐1(3H)‐one (IV) and 5H,7H‐Furo[3,4‐f][2,1,3]benzothiadiazol‐5‐one (V).
Authors: Molnar Balazs , Simig Gyula , Bako Tibor , Dancso Andras , Volk Balazs 
Published: August 2012

AbstractStarting from 5‐chloroisobenzofuran‐1(3H)‐one a novel synthesis of 5,6‐diaminophathalide (IV) is developed.
ChemInform Abstract: 12‐Tungstophosphoric Acid Immobilized on γ‐Fe2O3@SiO2 Core—Shell Nanoparticles: An Effective Solid Acid Catalyst for the Synthesis of Indole Derivatives in Water.
Authors: Rafiee Ezzat , Eavani Sara , Malaekeh‐Nikouei Bizhan 
Published: August 2012

AbstractThe catalyst is recovered using an external magnetic field and reused several times without loss of activity.
ChemInform Abstract: Ketosulfonyl Indoles in the Regiodefined Synthesis of Tryptophols and Related Indole Derivatives.
Authors: Palmieri Alessandro , Petrini Marino 
Published: August 2012

AbstractReduction of ketosulfonyl indoles such as (I) or (III) with sodium borohydride allows the entry to tryptophols in a regiocomplementary fashion with respect to the traditional oxirane ring‐opening by indoles under Friedel—Crafts conditions.
ChemInform Abstract: Diastereoselective Synthesis of C3‐Quaternary Indolenines Using α,β‐Unsaturated N‐Aryl Ketonitrones and Activated Alkynes.
Authors: Huehls C. Bryan , Hood Tyler S. , Yang Jiong 
Published: August 2012

AbstractTitle compounds, obtained by reaction of readily available α,β‐unsaturated N‐aryl ketonitrones and activated alkynes, are potentially applicable to the synthesis of complex indole alkaloids and related compounds.
ChemInform Abstract: New Multicomponent Domino Reaction on Water: Highly Diastereoselective Synthesis of Spiro[indoline‐3,4′‐pyrazolo[3,4‐b]pyridines] Catalyzed by NaCl.
Authors: Dandia Anshu , Laxkar Ashok Kumar , Singh Ruby 
Published: August 2012

AbstractThe novel regioselective protocol allows a significant improvement of the yields by addition of catalytic amounts of NaCl to the aqueous solvent.
ChemInform Abstract: Synthesis of Carbazolones and 3‐Acetylindoles via Oxidative C—N Bond Formation Through PIFA‐Mediated Annulation of 2‐Aryl Enaminones.
Authors: Ban Xu , Pan Yan , Lin Yingfu , Wang Songqing , Du Yunfei , Zhao Kang 
Published: August 2012

AbstractAn alternative approach to the synthesis of the title compounds under metal‐free and mild conditions including a simple work‐up is developed.
ChemInform Abstract: Chiral Proton Catalysis of Secondary Nitroalkane Additions to Azomethine: Synthesis of a Potent GlyT1 Inhibitor.
Authors: Davis Tyler A. , Danneman Michael W. , Johnston Jeffrey N. 
Published: August 2012

AbstractA known GlyT1 inhibitor (VI) is prepared via an enantioselective aza‐Henry reaction of 3‐nitroazetidine (III) with imine (IV) as key step.
ChemInform Abstract: Novel Isoxazole Polycyclic Aromatic Hydrocarbons as DNA‐Intercalating Agents.
Authors: Rescifina Antonio , Varrica Maria Giulia , Carnovale Caterina , Romeo Giovanni , Chiacchio Ugo 
Published: August 2012

AbstractThe third generation of isoxazole polycyclic aromatic hydrocarbons, possessing binding constants enabling easy diffusion of targeting remotely implanted tumors, is synthesized accordingly to the 1,3‐dipolar cycloaddition methodology.