bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiotensin receptor blockers use and the risk of lung cancer: A meta-analysis
Authors: Zhang Weizhen , Liang Zhenyu , Li Jing , Cai Shaoxi 
Published: October 2015

Background: Several reports suggest that the use of angiotensin receptor blockers (ARBs) is associated with lung cancer (LC) reduction. However, the results were contradictory. Methods: Four online databases were searched. The strength of the association between ARB and the risk of LC was measured by odds ratio (OR) and 95% confidence interval (CI). OR was analyzed by random-effects model. Results: Eight studies with 298000 subjects were included in this meta-analysis. Using of ARB was significantly associated with decreased LC risk (OR = 0.81; 95% CI 0.69–0.94; p = 0.005). In the subgroup analysis by race, Asians treated with ARB showed decreased LC risk (OR = 0.60; 95% CI 0.54–0.67; p < 0.00001). However, Caucasians treated with ARB did not show significantly decreased LC risk (OR = 0.90; 95% CI 0.79–1.02; p = 0.11). Subgroup analysis by duration of follow-up was conducted. The studies with less than 5 years showed significant result (OR = 0.79; 95% CI 0.64–0.97; p = 0.02). However, the studies with more than 5 years did not show significantly decreased LC risk (OR = 0.84; 95% CI 0.61–1.16; p = 0.29). Conclusions: This meta-analysis indicated that ARBs may be associated with decreased risk of LC.
Balloon protection of the Labbé vein during transarterial embolization of a dural arterio-venous fistula
Authors: Pop Raoul , Manisor Monica , Wolff Valérie , Aloraini Ziad , Tigan Leonardo , Kehrli Pierre , Marescaux Christian , Beaujeux Rémy 
Published: October 2015

Introduction Endovascular treatment of type III dural arterio-venous fistulas can be challenging if the fistulous point is close to a functionally important cortical vein. Methods A technique is described for temporary balloon protection of the vein of Labbé during transarterial Onyx embolization of a type III dural arterio-venous fistula. One illustrative case is presented. Careful anatomic consideration of the concerned venous segment (at the insertion point into the lateral sinus) and the choice of balloon minimized the risk of venous rupture. Results Using this method, satisfactory progression of Onyx was obtained within the arterio-venous shunt while preserving the patency of the Labbé vein. Conclusion Temporary balloon protection of the Labbé vein is a feasible option to preserve its patency during embolization of dural arterio-venous fistulas. To the authors’ knowledge, this is the first report on the use of temporary balloon protection of a cortical vein.
What next for environmental health?
Authors: Dhesi Surindar , Lynch Zena 
Published: October 2015

Aims: The aim of the wider research was to explore Health and Wellbeing Boards (HWBs) during their early development stages, with a focus on health inequalities and the role of environmental health (EH). This article presents empirical findings relating to challenges facing the EH profession in the new English public health (PH) system and offers new practical suggestions as to how they might be overcome in relation to educating and training the new generation of EH practitioners (EHPs). Methods: Four case study HWBs in the Midlands and North of England were followed for 18 months from early 2012. In addition, EHPs and managers from each English region were interviewed. In total, 50 semi-structured interviews were carried out, around 55 h of HWB meetings were observed, and documents associated with HWBs such as strategies and minutes of meetings were collected. Data were analysed thematically, both inductively and deductively, using Atlas.ti. Results: EH is largely invisible in the new PH system due to a variety of internal and external factors, including existing skill sets and practices. There is a new imperative to move away from reliance on statutory functions for funding and to engage with wider PH issues and colleagues, requiring new skills of evaluation and a change in perception from being ‘doers’ to include a greater role as ‘thinkers’. This is being recognised by EHPs and managers, who are seeking ways to adapt to these new expectations. Conclusion: Recent changes to the English PH system have led to a period of reflection and the beginnings of adaptation in EH to overcome new challenges. Linked to this is a need for graduate training to prepare new practitioners to think critically, to thrive and become high-level managers of the future, while being technically competent. We suggest a new, enhanced role for Chartered Institute of Environmental Health (CIEH)–accredited universities in securing the future of the profession by supporting new graduates. Specifically, a mentoring scheme could be introduced for the practical training element for new practitioners. This would help to embed criticality and evaluation in practice, provide consistency in training, and overcome the disconnect between academia and practice.
Intravenous immune globulin and thromboembolic adverse events in patients with hematologic malignancy
Authors: Ammann Eric M. , Jones Michael P. , Link Brian K. , Carnahan Ryan M. , Winiecki Scott K. , Torner James C. , McDowell Bradley D. , Fireman Bruce H. , Chrischilles Elizabeth A. 
Published: October 2015

Key Points
Acute myocardial infarction and ischemic stroke risk was 3 times higher during days 0 to 1 following IVIg treatment in patients with secondary hypogammaglobulinemia. In patients treated with IVIg for 1 year, the estimated increase in the absolute risk of a severe thromboembolic event was ∼1%.
High evolutionary turnover of satellite families in Caenorhabditis
Authors: Subirana Juan A. , Albà M. Mar , Messeguer Xavier 
Published: October 2015

Abstract
Background
The high density of tandem repeat sequences (satellites) in nematode genomes and the availability of genome sequences from several species in the group offer a unique opportunity to better understand the evolutionary dynamics and the functional role of these sequences. We take advantage of the previously developed SATFIND program to study the satellites in four Caenorhabditis species and investigate these questions.

Methods
The identification and comparison of satellites is carried out in three steps. First we find all the satellites present in each species with the SATFIND program. Each satellite is defined by its length, number of repeats, and repeat sequence. Only satellites with at least ten repeats are considered. In the second step we build satellite families with a newly developed alignment program. Satellite families are defined by a consensus sequence and the number of satellites in the family. Finally we compare the consensus sequence of satellite families in different species.

Results
We give a catalog of individual satellites in each species. We have also identified satellite families with a related sequence and compare them in different species. We analyze the turnover of satellites: they increased in size through duplications of fragments of 100-300 bases. It appears that in many cases they have undergone an explosive expansion. In C. elegans we have identified a subset of large satellites that have strong affinity for the centromere protein CENP-A. We have also compared our results with those obtained from other species, including one nematode and three mammals.

Conclusions
Most satellite families found in Caenorhabditis are species-specific; in particular those with long repeats. A subset of these satellites may facilitate the formation of kinetochores in mitosis. Other satellite families in C. elegans are either related to Helitron transposons or to meiotic pairing centers.
Rapid assay of stem cell functionality and potency using electric cell-substrate impedance sensing
Authors: Rutten Michael J. , Laraway Bryan , Gregory Cynthia R. , Xie Hua , Renken Christian , Keese Charles , Gregory Kenton W. 
Published: October 2015

AbstractRegenerative medicine studies using autologous bone marrow mononuclear cells (BM-MNCs) have shown improved clinical outcomes that correlate toin vitroBM-MNC invasive capacity. The current Boyden-chamber assay for testing invasive capacity is labor-intensive, provides only a single time point, and takes 36 hours to collect data and results, which is not practical from a clinical cell delivery perspective. To develop a rapid, sensitive and reproducible invasion assay, we employed Electric Cell-substrate Impedance Sensing (ECIS) technology. Chemokine-directed BM-MNC cell invasion across a Matrigel-coated Transwell filter was measurable within minutes using the ECIS system we developed. This ECIS-Transwell chamber system provides a rapid and sensitive test of stem and progenitor cell invasive capacity for evaluation of stem cell functionality to provide timely clinical data for selection of patients likely to realize clinical benefit in regenerative medicine treatments. This device could also supply robust unambiguous, reproducible and cost effective data as a potency assay for cell product release and regulatory strategies.
Transdifferentiation of differentiated stem cells contributes to remyelination
Authors: Chelluboina Bharath , Dinh Dzung H. , Veeravalli Krishna Kumar 
Published: October 2015

AbstractEvidence suggests that transdifferentiation of mesenchymal stem cells (MSCs) into various neuronal cells contributes to functional recovery after experimental spinal cord injury. Qiu et al. have recently published an exciting article in Stem Cell Research & Therapy demonstrating the transdifferentiation of already differentiated MSCs that contributes to remyelination of injured/regenerating axons, and thereby to functional recovery of spinal cord injured animals. The authors highlight the importance of interaction between neurotrophin-3 and tropomyosin receptor kinase C for the observed effects. This study provided important evidence that manipulation of rat bone marrow-derived MSCs before transplantation could enhance the therapeutic benefit of cell-based treatment.
Evaluating a multigene environmental DNA approach for biodiversity assessment
Authors: Drummond Alexei J. , Newcomb Richard D. , Buckley Thomas R. , Xie Dong , Dopheide Andrew , Potter Benjamin CM , Heled Joseph , Ross Howard A. , Tooman Leah , Grosser Stefanie , Park Duckchul , Demetras Nicholas J. , Stevens Mark I. , Russell James C. , Anderson Sandra H. , Carter Anna , Nelson Nicola 
Published: October 2015

Abstract

Background
There is an increasing demand for rapid biodiversity assessment tools that have a broad taxonomic coverage. Here we evaluate a suite of environmental DNA (eDNA) markers coupled with next generation sequencing (NGS) that span the tree of life, comparing them with traditional biodiversity monitoring tools within ten 20 × 20 meter plots along a 700 meter elevational gradient.

Results
From six eDNA datasets (one from each of 16S, 18S, ITS, trnL and two from COI) we identified sequences from 109 NCBI taxonomy-defined phyla or equivalent, ranging from 31 to 60 for a given eDNA marker. Estimates of alpha and gamma diversity were sensitive to the number of sequence reads, whereas beta diversity estimates were less sensitive. The average within-plot beta diversity was lower than between plots for all markers. The soil beta diversity of COI and 18S markers showed the strongest response to the elevational variation of the eDNA markers (COI: r = 0.49, p &lt; 0.001; 18S: r = 0.48, p &lt; 0.001). Furthermore pairwise beta diversities for these two markers were strongly correlated with those calculated from traditional vegetation and invertebrate biodiversity measures.

Conclusions
Using a soil-based eDNA approach, we demonstrate that standard phylogenetic markers are capable of recovering sequences from a broad diversity of eukaryotes, in addition to prokaryotes by 16S. The COI and 18S eDNA markers are the best proxies for aboveground biodiversity based on the high correlation between the pairwise beta diversities of these markers and those obtained using traditional methods.
Planning of urban underground infrastructure using a broadband seismic landstreamer — Tomography results and uncertainty quantifications from a case study in southwestern Sweden
Authors: Malehmir Alireza , Zhang Fengjiao , Dehghannejad Mahdieh , Lundberg Emil , Döse Christin , Friberg Olof , Brodic Bojan , Place Joachim , Svensson Mats , Möller Henrik 
Published: October 2015

We have developed a multicomponent broadband seismic landstreamer system based on digital sensors and particularly suitable for noisy environments and areas in which high-resolution images of the subsurface are desired. We have evaluated results, interpretations, and approaches using the streamer in the planning of an approximately 3-km-long underground tunnel in the city of Varberg in the southwestern Sweden. Prospective targets were imaging of the shallow (<20 m) bedrock surface and weak zones, such as fracture and shear zones. Over the course of three weeks, 25 profiles were acquired with a total length of approximately 7.5 km using a source and receiver spacing of 2–4 m. A novel approach of the data acquisition was to integrate the landstreamer with wireless sensors in areas in which the accessibility was restricted by roads and also to increase the source-receiver distances (offsets). Although the area was highly noisy, the seismic data, in conjunction with available boreholes, successfully led to delineation of the bedrock surface, its undulations, and areas of poor rock quality. To overcome challenges due to geologic complexities and crooked-line data acquisition, 3D tomographic inversion of first breaks was carried out. Comparisons of the results with the existing boreholes indicated that in most places, the bedrock surface was well resolved by the method, which supported the indication of weak zones in the bedrock, represented by low-velocity structures in the tomographic results. We also evaluated the effect of poor geodetic surveying, particularly regarding elevation data, which adulterated the tomography results toward undulating bedrock surfaces or zones of low velocities.
Evaluating the quality of bed length and area balance in 2D structural restorations
Authors: Lingrey Steven , Vidal-Royo Oskar 
Published: October 2015

The use of structural restorations as a tool to investigate structural evolution, fault and horizon relationships, and validity of interpretation has been widespread for more than four decades. The first efforts relied on hand-drafted bed-length measurements of commonly constant thickness stratigraphic units and were typically applied to fold-and-thrust belt settings. The advent of computer-assisted section construction and restoration software allowed for the assessment of more complicated structural interpretations by applying several new methods for forward and inverse strain transformation. Although quicker and more accurate than hand-drafted, the results of computer-aided structural modeling still need to be interrogated. We have reviewed the different strain transformation (restoration) methods available and their implications for bed length and area conservation: (1) fundamental simple shear and its two basic modes (flexural slip and inclined shear inversions), (2) fault-related folding techniques, and (3) the effects of mechanical stratigraphy and compaction. The assessment of the restoration methods was illustrated by examining two examples: the Mount Crandell Duplex Structure in southern Alberta and the Virgin River Extensional Basin in the southeast of Nevada. For both examples, we developed tables listing and confirming the deformed/restored state line lengths and areas. We believe that such tables should be provided for any strain transformation exercise, along with the restoration results as parameters for quality control, to prevent over- and underestimations that deviate more than 5% from the initial interpretation.
Introduction to this special section: Education in the geosciences
Authors: Buckner Lisa , Webb Susan 
Published: October 2015

Why should SEG members and all other geoscientists be concerned with the topic of education in geosciences? It's the future, not only of our professional society, but also the world. We should all be aware by now of the big crew change, which is already under way. How do we inspire and attract more students to pursue a degree or two in the geosciences to fill the positions vacated by a large portion of the geosciences workforce (the baby boomers) who will be retiring over the next decade? Education in the geosciences is the answer. [Figure: see text]
NGSeasy: a next generation sequencing pipeline in Docker containers
Authors: Folarin Amos A , Dobson Richard JB , Newhouse Stephen J 
Published: October 2015

Motivation: Bioinformatic pipelines often use large numbers of components and deploying them incurs substantial configuration and maintenance burden that remains a significant barrier to reproducible research. Our aim is to define a new paradigm and best practices for developing, distributing and running pipelines encapsulated in Docker containers (lightweight virtualization), with a focus on next generation sequencing (NGS) workflows. This approach provides several advantages, namely: efficiency, portability, versioning and reproducibility. Using the NGSeasy pipeline, a user can quickly deploy any pipeline version in any environment (e.g. operating systems, workstations, clusters, clouds). While this might also be achieved with a virtual machine (VM); VMs lack portability, have substantial overhead (disk, CPU, RAM), and require allocated resources to be provisioned statically – Docker, to a large extent, solves these issues.Results: We demonstrate best practices for packaging and execution of a multicomponent pipeline for NGS using a set of container building blocks which are versioned, modular and reusable. We present a basic ”proof of concept” evaluation of a next generation sequencing pipeline in Docker containers, capable of producing meaningful results, that are comparable with public and ”best practice” workflows, with little to no impact on standard computing performance.Availability: Both versioned Dockerfiles and container images for each component are published on GitHub and Docker Hub, respectively. The pipeline and containers can be pulled from Docker Hub and executed on any environment capable of running the Docker platform with minimum hardware requirements for running an NGS pipeline.
Features of audit of information security of business-systems
Authors: Ситнов  , Sitnov Alyeksyey 
Published: October 2015

In the proposed article, there were summarized and systematized views on information security audit business
systems. As a result of analysis the author expressed its viewpoint on an opportunity to apply the mentioned area of audit
to permanent impact of external environment on the business entities, described its essential advantages for economic
system of the business entities.
‘Solomon’: Terror and Terroir
Authors: Mort Graham 
Published: October 2015

Abstract
‘Solomon’ is a new work of short fiction, set in the United Kingdom and northern Uganda. It explores themes of memory, violence and recovery through the consciousness of a young Ugandan man. The accompanying essay ‘“Solomon”: Terror and Terroir’ reflects upon the genesis and writing of the story in the context of Terroir, a new book-length collection of fiction, with emphasis on depictions of violence and the relationship between the notion of terroir and human psychology.
The authentic voice of truth and the resonance of Being
Authors: Boddam-Whetham Jonathan 
Published: October 2015

Abstract
Heidegger’s radical thought in Being and Time ([1927] 1969) was that sociality is a primordial part of existence. However, as will be seen in this article, it is through the concept of authenticity that this relationality is subsumed into a totalized idea of the community of authentic People. Authenticity becomes intrinsically bound up with this new political destiny; no longer is it death as Dasein’s ownmost possibility, but it becomes community as a work of death, as shown by the genocides that haunt our shared history.
Building upon Nancy’s reorientation of Being and Time as a social ontology, I shall show how, by reading Heidegger’s philosophical opus via vocality and aurality, we are able to reorientate authenticity instead as a relation of shared resonance.
I will show how ‘voice’ can be shown to be a phenomenon that takes a privileged place; what it utters are not words or phrases as such, but it is rather a voice that speaks in between our words, it contaminates them. In short, the voice of the friend speaks the truth of our Being-with others, it calls from a relation between us which is arguably beyond both the phenomenological subject qua philosophical one. The voice opens us up to each other from in-between in an authentic relation of resonance.
During the Night Crops will Still Grow (unless the player sleeps)
Authors: Mollin David , Voegelin Salomé 
Published: October 2015

Abstract
The text represents a transcript made from a section of the sound work During the Night Crops will Still Grow (unless the player sleeps), which started with a recording made by one of the artists looking at Ed Ruscha’s Los Angeles Apartments shown at the Basel Kunstmuseum in Switzerland in 2013. On the recording, the artist can be heard moving slowly from photograph to photograph. At the same time we hear the voices of the artist and his blind mother discussing the catalogue of the exhibition at her house in Barry, South Wales. The transcript of this conversation translates the rhythms of their voices into text, and thereby returns the work back to its original source in architecture and procedure; grammar and light. For a recent exhibition entitled Nietzsche Cyclists and Mushrooms curated by Heidi Brunnschweiler at the Kunst Raum Riehen, Switzerland, the artists sent each day an image/text via Twitter for display, made with the installation in mind, thereby completing the mental loop that began with the audio recording of Ed Ruscha’s photographs, via the artist’s mother’s mind’s eye and back. The images accompanying this text are examples of such daily interventions. @mollin+voegelin.
Variation in body mass index and their determinants among married women in Uttar Pradesh
Authors: Maheshwari Sonam , Singh Brijesh , Singh Omprakash , Gupta Puneet 
Published: October 2015

The body mass index of married women is a high quality sign of a countryâ€™s health status as well as economic condition. NutritionÂ Â Â research in India has previously focused on the serious problem of under nutrition related to nutrient deficit and high rates of infection. BMI provide an indicator for supporting to wipe out many preventable diseases. Alteration in nutritional status plays an important role in the course of a personâ€™s health. Hence, BMI can be used as an indicator for nutrition status, and association with some diseases can be expected. This study observes the emerging nutrition transition among 7559 married and currently non â€“pregnant women aged between 15-49 years and also the differential impact of some demographic, socioeconomic, environmental and health-related factors on the body mass index living in Uttar Pradesh, India. The third wave of National Family Health Survey (2005-06) data provides nationally representative data on womenâ€™s weight and height. Average BMI is 21.11 kg/m2, and a turn down tendency in BMI was found during the last about 20 years.Â Body mass index increased with increasing age, education level of the woman, standard of living index. Lower BMI was especially pronounced among women who were living in rural areas, Hindus, employed women and women who are anemic.