bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Transcatheter and Surgical Aortic Valve Replacement in High-Risk Patients With Aortic Stenosis and Left Ventricular Dysfunction
Authors: Elmariah Sammy , Palacios Igor F. , McAndrew Thomas , Hueter Irene , Inglessis Ignacio , Baker Joshua N. , Kodali Susheel , Leon Martin B. , Svensson Lars , Pibarot Philippe , Douglas Pamela S. , Fearon William F. , Kirtane Ajay J. , Maniar Hersh S. , Passeri Jonathan J. 
Published: November 2013

Background—
The Placement of Aortic Transcatheter Valves (PARTNER) trial demonstrated similar survival after transcatheter and surgical aortic valve replacement (TAVR and SAVR, respectively) in high-risk patients with symptomatic, severe aortic stenosis. The aim of this study was to evaluate the effect of left ventricular (LV) dysfunction on clinical outcomes after TAVR and SAVR and the impact of aortic valve replacement technique on LV function.

Methods and Results—

The PARTNER trial randomized high-risk patients with severe aortic stenosis to TAVR or SAVR. Patients were stratified by the presence of LV ejection fraction (LVEF) <50%. All-cause mortality was similar for TAVR and SAVR at 30-days and 1 year regardless of baseline LV function and valve replacement technique. In patients with LV dysfunction, mean LVEF increased from 35.7±8.5% to 48.6±11.3% (
P
<0.0001) 1 year after TAVR and from 38.0±8.0% to 50.1±10.8% after SAVR (
P
<0.0001). Higher baseline LVEF (odds ratio, 0.90 [95% confidence interval, 0.86, 0.95];
P
<0.0001) and previous permanent pacemaker (odds ratio, 0.34 [95% confidence interval, 0.15, 0.81]) were independently associated with reduced likelihood of ≥10% absolute LVEF improvement by 30 days; higher mean aortic valve gradient was associated with increased odds of LVEF improvement (odds ratio, 1.04 per 1 mm Hg [95% confidence interval, 1.01, 1.08]). Failure to improve LVEF by 30 days was associated with adverse 1-year outcomes after TAVR but not SAVR.

Conclusions—
In high-risk patients with severe aortic stenosis and LV dysfunction, mortality rates and LV functional recovery were comparable between valve replacement techniques. TAVR is a feasible alternative for patients with symptomatic severe aortic stenosis and LV dysfunction who are at high risk for SAVR.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00530894.
Effects of interferential care: A community-based care program for persons with severe problems on several life areas
Authors: Roeg Diana PK , van de Goor Ien AM , Voogt Margot CM , van Assen Marcel ALM , Garretsen Henk FL 
Published: November 2013

Background and aims: Interferential care differs from the current community-based care programs in that it targets a larger, heterogeneous group and combines brokerage and full service elements in a multi-organizational care team. The team provides all the services itself, but with the aim to prepare clients within a few months for referral to regular (ambulant) healthcare services. The aim of this study was to assess the effectiveness of interferential care. Methods: In a multisite, pretest–posttest design, 523 patients of three interferential care teams were followed. Quality of life, problem severity, problems with referral and engagement were assessed at baseline, at referral and again after 6 months. Analyses were performed using linear mixed modeling. Results: Interferential care showed moderate to strong effects on quality of life and problem severity. These effects persisted (quality of life) or further improved (problem severity) until follow-up 6 months after referral to regular services. There were also small effects on both engagement and problems with referral. Conclusion: Interferential care offers significant improvements in quality of life and problem severity in persons who have severe problems on several life areas and who are currently not reached by healthcare services. It is a promising community-based care program for healthcare systems in which regular care already contains many elements of home-based practice.
Medication management for people with dementia in primary care: description of implementation in the DelpHi study
Authors: Fiß Thomas , Thyrian Jochen René , Wucherer Diana , Aßmann Grit , Kilimann Ingo , Teipel Stefan J , Hoffmann Wolfgang 
Published: November 2013

Abstract

Background
As the population ages, the relative and absolute number of age-associated diseases such as dementia will increase. Evaluation of the suitability and intake of medication and pharmacological treatment is an important aspect of care for people with dementia, especially if they live at home. Regular medication reviews and systematic cooperation between physicians and pharmacists are not common in routine care. Medication management (MM), based on such a comprehensive home medication review could help to reduce drug-related problems and costs. The present article presents a medication management specifically for the application in the ambulatory setting and describes its implementation as part of a larger trial.

Methods/design
A home medication review (HMR) and MM is implemented as part of the DelpHi study, a population based prospective, cluster-randomized controlled intervention study to test the efficacy and efficiency of the implementation of a collaborative care model in primary care.
Participants: people with dementia (PWD) and their caregivers are recruited by the patient’s general practitioner. Inclusion criteria are a positive screening result for dementia, living at home and regular intake of drugs. PWD are asked to specify their regular pharmacy which is asked to participate in the study, too.
Intervention: a comprehensive HMR is conducted as computer-assisted personal interview by specifically qualified Dementia Care Manager (DCM) at the people’s home. It includes detailed information about drugs taken, their storage, administration, adherence and adverse events. The MM is conducted in cooperation between DCM, pharmacist and general practitioner and consists of a pharmaceutical evaluation, pharmaceutical recommendations and their application. Pharmacists are trained and provided with regularly updated information. The MM is designed to give information and recommendations concerning antidementia drugs, occurrence of drug related problems, intake of anticholinergic drugs, potentially clinically relevant drug-drug-interactions, adverse drug events and medication adherence.

Discussion
The DelpHi-approach for medication management employs comprehensive instruments and procedures in the primary care setting under routine care conditions, and this approach should be useful in improving pharmacotherapy as part of the comprehensive treatment and care for people with dementia.

Trial registration
The trial is registered at ClinicalTrials.gov, number NCT01401582.
Tissue-specific regulation of the Na, K-ATPase by the cytosolic NaAF: some thoughts on brain function
Authors: Ray Tushar 
Published: November 2013

The dual topology P-2 ATPase, which consists of a α²β² tetramer, explains numerous functions of the cation transporting ATPase system. The ubiquitous cytosolic protein regulator (NaAF) of 170 k Da mass regulates P-2 ATPase function in a low Ca (µM) neighborhood where Ca acts as the terminal regulator in the intracellular signaling cascade. The Na, K- ATPase also seems to function as an H, K-ATPase or a Ca-ATPase in altered states based on the local environment (low pH or high Ca) in a tissue specific manner. These altered effects are analogous to that of the 80 k Da cytosolic HAF in regulating the gastric H, K-ATPase system of the parietal cells. However there are some important differences. The HAF stimulates the Na, K-ATPase but the NaAF cannot stimulate H, K-ATPase. Also, HAF is as effective as NaAF in stimulating the kidney Na, K-ATPase but about 60% as effective in stimulating brain Na, K-ATPase. These observations reveal that the Na, K- ATPase systems from kidney and brain, consisting of different kinds of αβ–isoforms, interact differently with the HAF molecule; thus substantiating that P-2 ATPase system plays different roles in different tissues in response to an universal NaAF. Another rare feature of the HAF is that it has histone kinase activity, suggesting that the HAF and NaAF may be capable of sending a direct signal to the nucleus for gene expression.In this paper, the central role of the NaAF-regulated Na, K-ATPase system in the activity and function of brain tissue is discussed. It is noted that the altered function of the nerve terminus located Na, K-ATPase system works as a Ca-pump (after depolarization) and as a Na-pump (in repolarization) in alternate sequence. The possible role of Ca-sensing receptor (CaR) in the voltage gated channeling of Ca has been raised and the possibility of a dual channel Na/H antiporter (NhaA) in pH homeostasis is discussed.
From zebrafish heart jogging genes to mouse and human orthologs: using Gene Ontology to investigate mammalian heart development.
Authors: Khodiyar Varsha K , Howe Doug , Talmud Philippa J , Breckenridge Ross , Lovering Ruth C 
Published: November 2013

For the majority of organs in developing vertebrate embryos, left-right asymmetry is controlled by a ciliated region; the left-right organizer node in the mouse and human, and the Kuppfer’s vesicle in the zebrafish. In the zebrafish, laterality cues from the Kuppfer’s vesicle determine asymmetry in the developing heart, the direction of ‘heart jogging’ and the direction of ‘heart looping’. ‘Heart jogging’ is the term given to the process by which the symmetrical zebrafish heart tube is displaced relative to the dorsal midline, with a leftward ‘jog’. Heart jogging is not considered to occur in mammals, although a leftward shift of the developing mouse caudal heart does occur prior to looping, which may be analogous to zebrafish heart jogging. Previous studies have characterized 30 genes involved in zebrafish heart jogging, the majority of which have well defined orthologs in mouse and human and many of these orthologs have been associated with early mammalian heart development. We undertook manual curation of a specific set of genes associated with heart development and we describe the use of Gene Ontology term enrichment analyses to examine the cellular processes associated with heart jogging. We found that the human, mouse and zebrafish ‘heart jogging orthologs’ are involved in similar organ developmental processes across the three species, such as heart, kidney and nervous system development, as well as more specific cellular processes such as cilium development and function. The results of these analyses are consistent with a role for cilia in the determination of left-right asymmetry of many internal organs, in addition to their known role in zebrafish heart jogging. This study highlights the importance of model organisms in the study of human heart development, and emphasises both the conservation and divergence of developmental processes across vertebrates, as well as the limitations of this approach.
First molecular evidence for the presence of Gerbillus latastei (Rodentia, Muridae) in Algeria
Authors: Nicolas Violaine , Souttou Karim , Gouissem Kheira , Doumandji Salaheddine , Denys Christiane 
Published: November 2013

AbstractRecent small mammal surveys in central Algeria (Hadjeb El Djmel, 50 km of Djelfa) allowed us to mention for the first time the presence of
The Quality of Periconception Medical Care in Women With Diabetes Needs Improvement
Authors: Riskin-Mashiah Shlomit , Auslander Ron , Almog Ronit 
Published: November 2013

OBJECTIVE
We evaluated the quality of periconception medical care in pregnant women with diabetes and assessed the influence of sociodemographic characteristics.

RESEARCH DESIGN AND METHODS
The study was based on retrospective data collection from electronic database on cohort of Israeli women at Clalit Health Services (CHS) with pre-existing diabetes who gave birth in 2008–2011. It included data on A1C and other laboratory test results, prescription fillings, diet and ophthalmology consultations, and sociodemographics extracted from CHS computerized systems. The performance of each of nine recommended measures in the periconception period and a composite quality score was evaluated; the score ranged from 0–8. Multivariate logistic regression was used to examine independent sociodemographic predictors of low-quality overall scores.

RESULTS
A total of 166 women gave birth to 180 infants; the performance of the different quality parameters ranged from 81% for A1C and kidney function tests to only 30% for dietary consultation and 41.1% for ophthalmology exam. Forty-nine percent of women had A1C &lt;7.0% (53 mmol/mol). Only 45% took folic acid, whereas 13.9% continued the use of potentially teratogenic drugs in the first trimester. One-third of women were in the low-quality (0–3) overall score. In the multiple logistic regression analysis, the only significant variables to predict lower composite quality scores were multiparity odds ratio of 3.43 (95% CI 1.66–7.10; P = 0.001), Arabian ethnicity 3.76 (1.78–7.92; P = 0.001), and immigrant 3.73 (1.25–11.16; P = 0.018).

CONCLUSIONS
The periconception medical care of diabetic women is suboptimal. More intensive and targeted care is needed in order to optimize periconception care of diabetic patients, especially in the high-risk subpopulations.
High resolution aerosol data from MODIS satellite for urban air quality studies
Authors: Chudnovsky A. , Lyapustin A. , Wang Y. , Tang C. , Schwartz J. , Koutrakis P. 
Published: November 2013

AbstractThe Moderate Resolution Imaging Spectroradiometer (MODIS) provides daily global coverage, but the 10 km resolution of its aerosol optical depth (AOD) product is not suitable for studying spatial variability of aerosols in urban areas. Recently, a new Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm was developed for MODIS which provides AOD at 1 km resolution. Using MAIAC data, the relationship between MAIAC AOD and PM2.5 as measured by the 27 EPA ground monitoring stations was investigated. These results were also compared to conventional MODIS 10 km AOD retrievals (MOD04) for the same days and locations. The coefficients of determination for MOD04 and for MAIAC are R2 =0.45 and 0.50 respectively, suggested that AOD is a reasonably good proxy for PM2.5 ground concentrations. Finally, we studied the relationship between PM2.5 and AOD at the intra-urban scale (≤10 km) in Boston. The fine resolution results indicated spatial variability in particle concentration at a sub-10 kilometer scale. A local analysis for the Boston area showed that the AOD-PM2.5 relationship does not depend on relative humidity and air temperatures below ~7 °C. The correlation improves for temperatures above 7–16 °C. We found no dependence on the boundary layer height except when the former was in the range 250–500 m. Finally, we apply a mixed effects model approach to MAIAC aerosol optical depth (AOD) retrievals from MODIS to predict PM2.5 concentrations within the greater Boston area. With this approach we can control for the inherent day-to-day variability in the AOD-PM2.5 relationship, which depends on time-varying parameters such as particle optical properties, vertical and diurnal concentration profiles and ground surface reflectance. Our results show that the model-predicted PM2.5 mass concentrations are highly correlated with the actual observations (out-of-sample R2 of 0.86). Therefore, adjustment for the daily variability in the AOD-PM2.5 relationship provides a means for obtaining spatially-resolved PM2.5 concentrations.
P2Y12-receptor-inhibiting antiplatelet strategies in acute coronary syndromes
Authors: Huber K. , Höchtl T. 
Published: November 2013

SummaryAntiplatelet therapy in acute coronary syndromes is essential for preventing stent thrombosis and for reducing major adverse cardiovascular events. Treatment strategy has changed over the last years by frequent use of more active agents inhibiting the ADP mediated activation of platelets instead of clopidogrel, such as prasugrel and ticagrelor. Compared to clopidogrel these modern antiplatelet drugs showed a significant reduction of efficacy endpoints as well as an acceptable safety profile in large multicenter randomized trials (TRITON TIMI 38, PLATO). Going in with higher efficacy a generally higher bleeding risk of prasugrel could be reduced by optimizing the maintenance dose in elderly and underweight patients (TRILOGY-ACS). However even prasugrel and ticagrelor have shown a delayed onset of action in special patient populations (e.g. STEMI) suggesting that the optimal ADP inhibitor has not been found yet. Results of the CHAMPION PHOENIX trial indicate that cangrelor, an intravenous agent, might fulfill these high expectations of an ideal platelet inhibitor in the first hours of an ACS in special patient cohorts.This review summarizes the results of most important clinical studies investigating the novel P2Y12 receptor inhibiting antiplatelet drugs.
Asymmetric Total Synthesis of (+)‐Bermudenynol, a C15Laurencia Metabolite with a Vinyl Chloride Containing Oxocene Skeleton, through Intramolecular Amide Enolate Alkylation
Authors: Kim Gyudong , Sohn Te‐ik , Kim Deukjoon , Paton Robert S. 
Published: November 2013

AbstractA substrate‐controlled asymmetric total synthesis of (+)‐bermudenynol, a compact and synthetically challenging C15 Laurencia metabolite that contains several halogen atoms, is reported. The oxocene core, which contains a vinyl chloride, was constructed by an efficient and highly stereoselective intramolecular amide enolate alkylation (IAEA). This result showcases the broad utility of the IAEA methodology as a useful alternative for cases in which the ring‐closing metathesis is inefficient.
Multifunctional Core–Shell Structured Nanocarriers for Synchronous Tumor Diagnosis and Treatment In Vivo
Authors: Chen Yin‐Yin , Ma Ping‐An , Yang Dong‐Mei , Wu Yuan , Dai Yun‐Lu , Li Chun‐Xia , Lin Jun 
Published: November 2013

AbstractMultifunctional, mesoporous, silica‐coated upconversion luminescent/magnetic NaGdF4:Yb/Er@NaGdF4:Yb@mSiO2PEG (referred to as UCNPS; PEG=polyethylene glycol) nanocomposites were fabricated through a phase‐transfer‐assisted surfactant‐templating coating process, followed by hydrophilic polymer (PEG) functionalization to improve the stability and biocompatibility. The UCNP core imparts the nanomaterials with luminescence and magnetic properties for simultaneous upconversion optical and magnetic resonance (MR) imaging, whereas the mesoporous shell affords the nanomaterials the ability to load the anticancer drug doxorubicin. Proof‐of‐principle in vitro and in vivo experiments are presented to demonstrate that the resultant composite nanomaterials can serve as nanotheranostics for synchronous upconversion luminescence/MR dual modal imaging and anticancer drug delivery; this finally realizes the integration of diagnostics and the treatment of cancers.
Severe hyperphosphatemia in a patient with chronic kidney disease and multiple myeloma–to strengthen the case toward renal replacement therapy?
Authors: Latus Joerg , Höring Elisabeth , Voehringer Matthias , Ratge Dieter , Alscher M. Dominik , Braun Niko 
Published: November 2013

Key Clinical MessageWe report a patient with multiple myeloma and chronic kidney disease who presented with severe hyperphosphatemia in the outpatient clinic without any related symptoms. Initial differential diagnosis: Tumor lysis syndrome or chronic kidney disease. Further work‐up revealed pseudohyperphosphatemia. In general, treatment is not necessary if the true phosphate level is within the reference range and the patient is asymptomatic.
Palladium‐Catalyzed Highly Regioselective Mizoroki–Heck Arylation of Allylamines with Aryl Chlorides
Authors: Zhang Lingjuan , Jiang Zhen , Dong Chaonan , Xue Xiao , Qiu Ruiying , Tang Weijun , Li Huanrong , Xiao Jianliang , Xu Lijin 
Published: November 2013

AbstractPalladium catalyst systems for the regioselective Mizoroki–Heck arylation of N,N‐diprotected and N‐protected allylamines with aryl chlorides have been developed. Pd(OAc)2 in combination with appropriate additives could efficiently catalyze the linear arylation of N,N‐diprotected allylamines with aryl chlorides in toluene to give exclusively the γ‐arylated products in good to excellent yields and with excellent regio‐ and stereocontrol and good functional group tolerance. With use of a catalytic mixture of Pd(OAc)2 and 1,1'‐bis(diphenylphosphino)ferrocene, the arylation of N‐protected allylamines with aryl chlorides could be accomplished in ethylene glycol/DMSO, which afforded complete β‐regioselectivity with good functional group tolerance. The steric and electronic properties of allylamine substrates are found to be critical to the catalytic activity and regiocontrol in both linear and internal arylations.
Micropipette Contact Technique as a Tool to Reveal, Characterize, and Modify Nanopore Electrodes
Authors: Battistel Dario , Pecchielan Giulia , Daniele Salvatore 
Published: November 2013

AbstractThis paper reports on the use of a micropipette contact method (MCM) to reveal and characterise single submicrometer‐sized pores randomly distributed within a thin insulating alumina layer (250 nm thickness) that coats a platinum film substrate (Pt/Al2O3). Moveable micropipette probes, with orifice radii of 40–50 μm, filled with electrolyte solutions, are brought in contact with the sample surface to form a microcell and allow electrochemical reactions to be confined within a limited contact region. The aqueous solutions inside the micropipettes contain Ru(NH3)63+ or Ag+ ions and cyclic voltammograms (CVs) are obtained for several locations of 500×500 μm2 above the Pt/Al2O3 sample. The presence of nanoscopic pores is revealed by sigmoidally shaped volatmmograms, which are recorded when Ru(NH3)63+ is used as redox probe. From the steady‐state limiting current and the theoretical equation that applies for recessed microelectrodes, the radius of each platinum disk at the bottom of the pore is evaluated. In this way, pore sizes spanning from about 50 nm to 350 nm are revealed. Similar information is obtained by the use of the MCM with the pipette filled with Ag+ ions. In this case, CVs typical for nucleation and growth of metallic silver are recorded. The volume of a single pore is evaluated from the charge involved in the anodic stripping process of the metal deposited. Potential step measurements and relevant current (I) against time (t) transients allow establishing that only a single nucleus can be grown in each submicometer‐sized pore. Moreover, a diffusion coefficient value of 1.41×10−5 cm2 s−1 for Ag+ is evaluated from the experimental I vs. t1/2 linear plot. Finally, the measurements performed at the Pt/Al2O3 sample are compared with those obtained by using a plain platinum disk electrode 3 mm diameter as substrate for MCM measurements.
Outstanding Catalytic Activity of Ultra‐Pure Platinum Nanoparticles
Authors: Januszewska Aneta , Dercz Grzegorz , Piwowar Justyna , Jurczakowski Rafal , Lewera Adam 
Published: November 2013

AbstractSmall (4 nm) nanoparticles with a narrow size distribution, exceptional surface purity, and increased surface order, which exhibits itself as an increased presence of basal crystallographic planes, can be obtained without the use of any surfactant. These nanoparticles can be used in many applications in an as‐received state and are threefold more active towards a model catalytic reaction (oxidation of ethylene glycol). Furthermore, the superior properties of this material are interesting not only due to the increase in their intrinsic catalytic activity, but also due to the exceptional surface purity itself. The nanoparticles can be used directly (i.e., as‐received, without any cleaning steps) in biomedical applications (i.e., as more efficient drug carriers due to an increased number of adsorption sites) and in energy‐harvesting/data‐storage devices.