bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychose pour tous : la jeunesse au risque du« syndrome de psychose atténuée » ?
Authors: Evrard Renaud , Rabeyron Thomas 
Published: June 2014

De nombreuses études ont mis en évidence des expériences d’hallucinations et de délires survenant chez des enfants et des adolescents, mais pour lesquels le diagnostic de psychose ne semble pas pertinent. Alors que différents modèles existent pour penser une clinique différentielle de telles expériences réputées psychotiques, la cinquième version du Manuel Diagnostique et Statistique des Troubles Mentaux (DSM-5) propose d’appeler de tels vécus « symptômes psychotiques atténués », suggérant un « risque de psychose » qu’il serait crucial de traiter au plus vite pour en améliorer le pronostic. Nous proposons dans cet article une revue de littérature pour comprendre ce qu’implique ce nouveau « syndrome de psychose atténuée » dans la perspective de son éventuelle application auprès de jeunes patients. Cette revue de littérature nous conduit plus largement à étudier certains vécus hallucinatoires et transitoires se produisant à l’adolescence, à aborder la question de leur prise en charge et de leur impact sur notre compréhension des signes prodromiques de la psychose à partir d’un modèle pleinement dimensionnel de la psychose, prenant en compte la spécificité de l’adolescence, notamment le recours aux croyances et expériences paranormales en tant que stratégies structurantes.
Topography-guided Photorefractive Keratectomy for Irregular Astigmatism After Small Incision Lenticule Extraction
Authors: Ivarsen Anders , Hjortdal Jesper Ø. 
Published: June 2014

PURPOSE:
To report the outcome of topography-guided photorefractive keratectomy (PRK) after complicated small incision lenticule extraction (SMILE).

METHODS:
Retrospective case series of 5 eyes with irregular topography and ghost images after complicated SMILE. All eyes received transepithelial topography-guided PRK. Two eyes were treated with 0.02% mitomycin C. Patients were examined after a minimum of 3 months with evaluation of uncorrected (UDVA) and corrected (CDVA) distance visual acuity, Pentacam tomography (Oculus Optikgeräte, Wetzlar, Germany), and whole-eye aberrometry.

RESULTS:
In 3 eyes, subjective symptoms were diminished and UDVA, CDVA, topography, and corneal wavefront aberrations were improved. The remaining 2 eyes developed significant haze with worsened topography and wavefront aberrations. One eye experienced a two-line reduction in CDVA. Eyes with haze development had not been treated with mitomycin C.

CONCLUSIONS:
Transepithelial topography-guided PRK may reduce visual symptoms after complicated SMILE if postoperative haze can be controlled. To reduce the risk of haze development, application of mitomycin C may be considered.

[
J Refract Surg.
2014;30(6):429–432.]
Vitamin D Inhibits the Occurrence of Experimental Cerebral Malaria in Mice by Suppressing the Host Inflammatory Response
Authors: He Xiyue , Yan Juan , Zhu Xiaotong , Wang Qinghui , Pang Wei , Qi Zanmei , Wang Meilian , Luo Enjie , Parker Daniel M. , Cantorna Margherita T. , Cui Liwang , Cao Yaming 
Published: June 2014

Abstract
In animal models of experimental cerebral malaria (ECM), neuropathology is associated with an overwhelming inflammatory response and sequestration of leukocytes and parasite-infected RBCs in the brain. In this study, we explored the effect of vitamin D (VD; cholecalciferol) treatment on host immunity and outcome of ECM in C57BL/6 mice during Plasmodium berghei ANKA (PbA) infection. We observed that oral administration of VD both before and after PbA infection completely protected mice from ECM. VD administration significantly dampened the inducible systemic inflammatory responses with reduced circulating cytokines IFN-γ and TNF and decreased expression of these cytokines by the spleen cells. Meanwhile, VD also resulted in decreased expression of the chemokines CXCL9 and CXCL10 and cytoadhesion molecules (ICAM-1, VCAM-1, and CD36) in the brain, leading to reduced accumulation of pathogenic T cells in the brain and ultimately substantial improvement of the blood–brain barriers of PbA-infected mice. In addition, VD inhibited the differentiation, activation, and maturation of splenic dendritic cells. Meanwhile, regulatory T cells and IL-10 expression levels were upregulated upon VD treatment. These data collectively demonstrated the suppressive function of VD on host inflammatory responses, which provides significant survival benefits in the murine ECM model.
Systemic Response to Ultraviolet Radiation Involves Induction of Leukocytic IL-1β and Inflammation in Zebrafish
Authors: Banerjee Sanjita , Leptin Maria 
Published: June 2014

Abstract
Ultraviolet radiation is a pervasive stimulus with wide-ranging effects on all living forms. The effects of UV vary from physiological to pathological, depending on levels of exposure, but the immune response at the organismal level is not well understood. We use the zebrafish embryo and larva to study immune responses to UV stress in vivo. UV exposure causes inflammation characterized by systemic induction of proinflammatory cytokines. Leukocytes are an important component of this systemic response and upregulate IL-1β expression proportional to the dose of UV exposure. Increased levels of this proinflammatory cytokine counteract the lethal effect of high doses of UV.
The Majority of Human Memory B Cells Recognizing RhD and Tetanus Resides in IgM+ B Cells
Authors: Della Valle Luciana , Dohmen Serge E. , Verhagen Onno J. H. M. , Berkowska Magdalena A. , Vidarsson Gestur , Ellen van der Schoot C. 
Published: June 2014

Abstract
B cell memory to T cell–dependent (TD) Ags are considered to largely reside in class-switched CD27+ cells. However, we previously observed that anti-RhD (D) Igs cloned from two donors, hyperimmunized with D+ erythrocytes, were predominantly of the IgM isotype. We therefore analyzed in this study the phenotype and frequency of D- and tetanus toxoid–specific B cells by culturing B cells in limiting dilution upon irradiated CD40L-expressing EL4.B5 cells and testing the culture supernatant. Most Ag-specific B cells for both TD Ags were found to reside in the IgM-expressing B cells, including CD27− B cells, in both hyperimmunized donors and nonhyperimmunized volunteers. Only shortly after immunization a sharp increase in Ag-specific CD27+IgG+ B cells was observed. Next, B cells were enriched with D+ erythrocyte ghosts and sorted as single cells. Sequencing of IGHV, IGLV, IGKV, and BCL6 genes from these D-specific B cell clones demonstrated that both CD27−IgM+ and CD27+IgM+ B cells harbored somatic mutations, documenting their Ag-selected nature. Furthermore, sequencing revealed a clonal relationship between the CD27−IgM+, CD27+IgM+, and CD27+IgG+ B cell subsets. These data strongly support the recently described multiple layers of memory B cells to TD Ags in mice, where IgM+ B cells represent a memory reservoir which can re-enter the germinal center and ensure replenishment of class-switched memory CD27+ B cells from Ag-experienced precursors.
UNIVERSIDADES CORPORATIVAS: UMA NOVA CONCEPÇÃO PARA O ENSINO SUPERIOR?
Authors: Assis Pires Luciene Lima 
Published: June 2014

RESUMO: No presente artigo, analisa-se a estrutura e a expansão das universidades corporativas no Brasil. Em um primeiro momento apresenta-se o modelo seguido por essas universidades, que incorporaram a tradução da expressão corporate university utilizadas nos Estados Unidos, sem incorporarem a idéia brasileira de se trabalhar com ensino / pesquisa / extensão. Em seguida demonstra-se como estas instituições se estruturam e de que forma se organizam. Enumera-se as principais universidades corporativas já instaladas e o sistema de convênios que realizam com instituições conceituadas para assegurarem a certificação dos cursos. Palavras-Chave: Ensino Superior - Universidade Corporativa - Universidade Acadêmica
FORMAÇÃO, CURRÍCULO E ENSINO DE GRADUAÇÃO
Authors: Corbiniano Simone Alexandre Martins 
Published: June 2014

Resumo O ensino na universidade tem enfatizado cada vez mais em seus currículos as necessidades do mercado de trabalho e do desenvolvimento econômico e tecnológico. Contudo, é preciso empenhar-se no diálogo acerca da formação do cidadão e, em especial, do educador valorizando os nexos que constituem essa formação como processo mais amplo, não restrito à formação profissional. Ao situar a questão da formação na atualidade, cabe lembrar o sentido humano, cultural e histórico que a instituição universitária logra na sociedade. Decorrente desse sentido, o ensino de graduação deve voltar-se não somente ao desenvolvimento de habilidades que possibilitem às pessoas participarem da dimensão econômica da sociedade, mas, sobretudo, à formação comprometida com a busca do saber, a criação e a crítica. Esses princípios são indispensáveis à formação dos sujeitos em sua totalidade humana.
Influence of magnetic field on germination, growth and production of tomato
Authors: Jedlička Jaroslav , Paulen Oleg , Ailer Štefan 
Published: June 2014

In the study with tomatoes, there was ivestigated the impact of extremely low frequency electromagnetic fields on seed germination of tomato (Solanum lycopersicum L.) after treatment before sowing, as well as the growth of young plants that were exposed to low frequency electromagnetic field before planting in the field when growing transplants under cover. In the experiments conducted in two consecutive years (2012 and 2013), we followed the length of seed germination period of tomato variety „Pavlína", growth of young plants expressed in plant height and root length, and the fruit size. Magnetization of seeds and young plants was carried out in laboratory conditions, plant growth was evaluated under cover prior to planting, and fruit traits were followed in field conditions where plants were grown on experimental plots (80.0 m2). The plants were grown in accordance with the standards of an agricultural practice for tomato. At the generative phase, the fruits were collected at regular intervals, and their number and weight were evaluated. Low frequency electromagnetic fields acting at the three inductance levels (20, 40 and 60 mT) and exposure of 20 minutes a day with frequency of 50 Hz, significantly positively influenced the germination, plant growth and fruit size of the studied tomato variety.
Sensory evaluation of coob 500 chicken meat after application of different additives in their nutrition
Authors: Mellen Martin , Pavelková Adriana , Haščí­k Peter , Bobko Marek , Čuboň Juraj 
Published: June 2014

The objective of the experiment was to verify the effect of different feed additives in nutrition of Cobb 500 broiler chickens on the sensory quality of breast and thigh muscle modified by baking at temperature 200 ºC for 60 minutes. The experiment included 250 one-day-old Cobb 500 hybrid chickens, which were divided into 5 groups (n=50): control (I) and experimental groups (E1 with Agolin Poultry at doses of 100 mg.kg-1, E2 with Agolin Tannin Plus at doses of 500 mg.kg-1, E3 with Biostrong 510+FortiBac at doses of 1000 mg.kg-1 and E4 with Agolin Acid at doses of 1000 mg.kg-1). The chickens were fed during 42 days of age by ad libitum system with feed mixtures: BR1 starter feed mixture (until the of 10th day of age), BR2 growth feed mixture (from 11th to 20th day of age), BR3 growth feed mixture (from 21st to 35th days of age) and BR4 final feed mixture (from 36th to 42nd days of age). Feed mixtures were produced with coccidiostats in powder form. Panellists evaluate aroma, juiciness, taste and tenderness on 5 point hedonic scale where 1 (the worst) and 5 (the best) were the extremes of each characteristic. Significant differences were found between control and experimental group E3 in juiciness and tenderness of breast muscles and between control and experimental group E2 in smell of thigh muscles. Sensory evaluation of breast and thigh muscles in Cobb 500 chickens after application of different feed additives indicated that these additives have not worsened the quality of meat. The highest sensory score was obtained in experimental group E4 (with addition of Agolin Acid at the dose of 1000 mg.kg-1).
Metal Ion Release: Also a Concern for Ceramic-on-Ceramic Couplings?
Authors: Beraudi Alina , Stea Susanna , De Pasquale Dalila , Bordini Barbara , Catalani Simona , Apostoli Pietro , Toni Aldo 
Published: June 2014

BIOLOX® delta is the newest ceramic composite material of the BIOLOX® family and its use in hip devices represents a good alternative to Metal-on-Metal or Metal-on-Polyethylene coupling. Some Metal-on-Metal hip devices have shown chromium and cobalt release, which promoted toxic effects. Furthermore, the ceramic composite contains trivalent chromium, even if strongly bound to the alumina lattice. The present study is aimed at detecting any ‘in vivo’ release of chromium ions from BIOLOX® delta bearings in the blood, erythrocytes and urine of patients. Twenty patients implanted with total hip arthroplasty (THA) with BIOLOX® delta-BIOLOX® delta couplings and 21 subjects with no implanted prostheses were studied. Inductively coupled plasma mass spectrometry equipped with dynamic reaction cell was used for analysis. In the THA group the Cr ions values were; in blood mean 0.21 µg/l (±0.09), in serum 0.21 µg/l (±0.12), in normalized erythrocytes 0.13 µg/l (±0.09), in normalized urine 0.12 µg/g creatinine (±0.13). In the control group the Cr ions values were; in blood mean 0.22 µg/l (st dev 0.14), in serum 0.17 µg/l (±0.08), in normalized erythrocytes 0.13 µg/l (±0.11), in normalized urine 0.07 µg/g creatinine (±0.08). The Lab reference values were 0.1-5.0 µg/l for blood, 0.1-0.5 µg/l for serum, 0.14-4.58 µg/l for normalised erythrocytes and 0.05-2.2 µg/l for urine. All samples in both groups resulted in chromium levels within the normal reference range and the safety of BIOLOX® delta ceramics, in terms of chromium ions release, has been demonstrated.
Cup Version Can be Accurately Measured on the False Profile View Radiograph
Authors: Lee Joshua K.L. , Sardana Vandit , White Craig , Speirs Andrew , Beaulé Paul E. 
Published: June 2014

Introduction Accurate measurement of cup version on plain radiographs remains difficult due to the two-dimensional projection of an ellipse and difficulty obtaining reproducible radiographs. Purpose Determine: 1) if the cup angle measured on the false profile view (FPV) could be used to determine radiographic cup version; 2) how patient positioning would affect cup angle measurement on the FPV; 3) if implant cup design affects cup angle measurement. Materials and methods Three cup version positions were assessed in a sawbone: 13° (normal); 28° (excessive anteversion) and −2° (retroversion). Cup angle was measured on the FPV at five different degrees of pelvic rotation within each cup version group. Pelvic rotation was quantified using the ratio of the inter-femoral head distance measured on the FPV versus the anteroposterior radiographs (FP/AP ratio). Eighty patients (40 metal-on-polyethylene, 40 metal-on-metal) post-total hip were also assessed. Cup version was assessed with Einzel-Bild-Roentgen-Analysis software (EBRA). R2 was calculated to assess correlation between both measurement methods. Results For the sawbone model, an R2 of 0.95 was obtained. For patients, overall R2 was 0.56 with an FP/AP ratio of 0.3-0.49 having an R2 of 0.72. The EBRA anteversion versus cup angle scatterplot had an R2 of 0.72 (95%CI: +/-7.8°). Subgroup analysis revealed no differences between the metal-on-poly and metal-on-metal for cup angle measurements. The intra-class coefficient for intra- and inter-observer reliability for all cases (individual and combined FP/AP groups) was 0.98 to 0.99. Conclusion The FPV cup angle measurement value provides an accurate measurement of radiographic cup anteversion with well-defined patient position parameters.
Computational Models of Aortic Coarctation in Hypoplastic Left Heart Syndrome: Considerations on Validation of a Detailed 3D model
Authors: Biglino Giovanni , Corsini Chiara , Schievano Silvia , Dubini Gabriele , Giardini Alessandro , Hsia Tain-Yen , Pennati Giancarlo , Taylor Andrew M. ,   MOCHA collaborative group
Published: June 2014

Background Reliability of computational models for cardiovascular investigations strongly depends on their validation against physical data. This study aims to experimentally validate a computational model of complex congenital heart disease (i.e., surgically palliated hypoplastic left heart syndrome with aortic coarctation) thus demonstrating that hemodynamic information can be reliably extrapolated from the model for clinically meaningful investigations. Materials and methods A patient-specific aortic arch model was tested in a mock circulatory system and the same flow conditions were re-created in silico, by setting an appropriate lumped parameter network (LPN) attached to the same three-dimensional (3D) aortic model (i.e., multi-scale approach). The model included a modified Blalock-Taussig shunt and coarctation of the aorta. Different flow regimes were tested as well as the impact of uncertainty in viscosity. Results Computational flow and pressure results were in good agreement with the experimental signals, both qualitatively, in terms of the shape of the waveforms, and quantitatively (mean aortic pressure 62.3 vs. 65.1 mmHg, 4.8% difference; mean aortic flow 28.0 vs. 28.4% inlet flow, 1.4% difference; coarctation pressure drop 30.0 vs. 33.5 mmHg, 10.4% difference), proving the reliability of the numerical approach. It was observed that substantial changes in fluid viscosity or using a turbulent model in the numerical simulations did not significantly affect flows and pressures of the investigated physiology. Results highlighted how the non-linear fluid dynamic phenomena occurring in vitro must be properly described to ensure satisfactory agreement. Conclusions This study presents methodological considerations for using experimental data to preliminarily set up a computational model, and then simulate a complex congenital physiology using a multi-scale approach.
SCOPE: A Cost Analysis of an Automated Serials Record System
Authors: Koenig Michael E. D. , Finlay Alexander C. , Cushman Joann G. , Detmer James M. 
Published: June 2014

A computerized serials record and control system developed in 1968/69 for the Technical Information Department of Pfizer Inc. is described and subjected to a cost analysis. This cost analysis is conducted in the context of an investment decision, using the concept of net present value, a method not previously used in library literature. The cost analysis reveals a positive net present value and a system life break-even requirement of seven years at a 10% cost of capital. This demonstrates that such an automated system can be economically justifiable in a library of relatively modest size (approx. 1,100 serial and periodical titles). It may be that the break-even point in terms of collection size required for successful automation of serial records is smaller than has been assumed to date.
A Computer System for Effective Management of a Medical Library Network
Authors: Nance Richard E. , Wickham W. Kenneth , Duggan Maryann 
Published: June 2014

TRIPS (TALON Reporting and Information Processing System) is an interactive software system for generating reports to NLM on regional medical library network activity and constitutes a vital part of a network management information system (NEMIS) for the South Central Regional Medical Library Program. Implemented on a PDP-lOfSRU 1108 interfaced system, TRIPS accepts paper tape input describing network transactions and generates output statistics on disposition of requests, elapsed time for completing filled requests, time to clear unfilled requests, arrival time distribution of requests by day of month, and various other measures of activity andjor performance. Emphasized in the TRIPS design are flexibility, extensibility, and system integrity. Processing costs, neglecting preparation of input which may be accomplished in several ways, are estimated at $.05 per transaction, a transaction being the transmittal of a message from one library to another.
Antiphospholipid Syndrome: primary or secondary to Systemic Lupus Erythematosus? Description of a clinical case of avitaminosis D in premenopausal woman with pseudo-Cushing syndrome
Authors: Turrin Mauro , Martinelli Sergio 
Published: June 2014

Low vitamin D levels have been described in obese individuals and in some autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) and primary antiphospholipid syndrome (pAPS). In particular, more than 50% of premenopausal women with pAPS have hypovitaminosis D. In this issue we report a case of an obese, premenopausal, and hypertensive woman with pseudo-Cushing syndrome, affected by deep venous thrombosis associated with pulmonary embolism after rib fracture who presented hypovitaminosis D. 7 years before, diagnosis of pAPS had been made after the detection of thrombocytopenia (present at a young age) and arterial ischemia of a lower limb. For seven years she was treated with acetylsalicylic acid without complications. We found positive anti-dsDNA antibodies, a triple antiphospholipid antibodies (aPL) positivity and levels of vitamin D < 4 µg/l. The case report arises some questions: is vitamin D deficiency due to obesity or APS? Is the positivity of anti-dsDNA indicative of progression to SLE? Is preventive therapy with hydroxychloroquine indicated? Does the high-risk aPL profile justify a high-intensity and life-long anticoagulation regimen?
SMOS salinity in the subtropical North Atlantic salinity maximum: 1. Comparison with Aquarius and in situ salinity
Authors: Hernandez O. , Boutin J. , Kolodziejczyk N. , Reverdin G. , Martin N. , Gaillard F. , Reul N. , Vergely J. L. 
Published: June 2014

AbstractSea surface salinity (SSS) measured from space by the Soil Moisture and Ocean Salinity (SMOS) mission is validated in the subtropical North Atlantic Ocean. 39 transects of ships of opportunity equipped with thermosalinographs (TSG) crossed that region from 2010 to 2012, providing a large database of ground truth SSS. SMOS SSS is also compared to Aquarius SSS. Large seasonal biases remain in SMOS and Aquarius SSS. In order to look at the capability of satellite SSS to monitor spatial variability, especially at scales less than 300 km (not monitored with the Argo network), we first apply a monthly bias correction derived from satellite SSS and In Situ Analysis System (ISAS) SSS differences averaged over the studied region. Ship SSS averaged over 25 km is compared with satellite and ISAS SSS. Similar statistics are obtained for SMOS, Aquarius, and ISAS products (root mean square error of about 0.15 and global correlation coefficient r of about 0.92). However, in the above statistics, SSS varies due to both large‐scale and mesoscale (here for scales around 100 km) variability. In order to focus on mesoscale variability, we consider SSS anomalies with respect to a monthly climatology. SMOS SSS and Aquarius SSS anomalies are more significantly correlated (r > 0.5) to TSG SSS anomaly than ISAS. We show the effective gain of resolution and coverage provided by the satellite products over the interpolated in situ data. We also show the advantage of SMOS (r = 0.57) over Aquarius (r = 0.52) to reproduce SSS mesoscale features.