bluuebunny/crossref_metadata_2025_split huggingface dataset:
The practices of artist‐entrepreneurs located outside Canada's creative hubs viewed through the lens of the pragmatic sociology of critique
Authors: Bérubé Julie , Gauthier Jacques‐Bernard 
Published: August 2024

AbstractArtists‐entrepreneurs struggle with the tension between their artistic and entrepreneurial values. Previous research on this tension focuses on urban creative hubs and shows the presence of politicians to create, with the artists, a structure constituted of investment formulas to ease this tension. Based on Boltanski and Thévenot's On Justification theory, our research focuses on the case of artist‐entrepreneurs located outside Canada's creative hubs. The tension between artistic and entrepreneurial values is expressed as a tension between the inspired and market worlds, which is managed through the civic world in Canadian creative hubs. The results of 50 semi‐structured interviews with non‐urban Canadian artist‐entrepreneurs reveal that politicians are less implicated in these regional cultural industries. In order to manage the tension between artistic and entrepreneurial values, artists themselves are developing individual and collective investment formulas to create structure in the cultural industries that compensates for the low‐level of involvement by politicians. Thus, we identify that the tension between the inspired and market worlds is managed through the presence of the projective world in the case of Canada's non‐urban artist‐entrepreneurs.
N‐acetylgalactosaminyltransferase GALNT6 is a potential therapeutic target of clear cell renal cell carcinoma progression
Authors: Sun Luhaoran , Li Zeyu , Shu Peng , Lu Min 
Published: August 2024

AbstractHigh expression of truncated O‐glycans Tn antigen predicts adverse clinical outcome in patients with clear cell renal cell carcinoma (ccRCC). To understand the biosynthetic underpinnings of Tn antigen changes in ccRCC, we focused on N‐acetylgalactosaminyltransferases (GALNTs, also known as GalNAcTs) known to be involved in Tn antigen synthesis. Data from GSE15641 profile and local cohort showed that GALNT6 was significantly upregulated in ccRCC tissues. The current study aimed to determine the role of GALNT6 in ccRCC, and whether GALNT6‐mediated O‐glycosylation aggravates malignant behaviors. Gain‐ and loss‐of‐function experiments showed that overexpression of GALNT6 accelerated ccRCC cell proliferation, migration, and invasion, as well as promoted ccRCC‐derived xenograft tumor growth and lung metastasis. In line with this, silencing of GALNT6 yielded the opposite results. Mechanically, high expression of GALNT6 led to the accumulation of Tn antigen in ccRCC cells. By undertaking immunoprecipitation coupled with liquid chromatography/mass spectrometry, vicia villosa agglutinin blot, and site‐directed mutagenesis assays, we found that O‐glycosylation of prohibitin 2 (PHB2) at Ser161 was required for the GALNT6‐induced ccRCC cell proliferation, migration, and invasion. Additionally, we identified lens epithelium‐derived growth factor (LEDGF) as a key regulator of GALNT6 transcriptional induction in ccRCC growth and an upstream contributor to ccRCC aggressive behavior. Collectively, our findings indicate that GALNT6‐mediated abnormal O‐glycosylation promotes ccRCC progression, which provides a potential therapeutic target in ccRCC development.
Mogamulizumab‐assoziierter Rash – Fallserie und aktuelle Literatur
Authors: Hansen Inga , Abeck Finn , Menz Anne , Schneider Stefan W. , Booken Nina 
Published: August 2024

ZusammenfassungDer CC‐Chemokinrezeptor‐4‐Antikörper Mogamulizumab ist zur Zweitlinientherapie der Mycosis fungoides und des Sézary‐Syndroms zugelassen. Zu den häufigsten Nebenwirkungen gehört der Mogamulizumab‐assoziierte Rash (MAR), der sich klinisch sowie histologisch vielgestaltig präsentieren kann. Rein klinisch ist der MAR häufig nicht von einem Progress der Grunderkrankung zu unterscheiden, weshalb der histologischen Untersuchung eine wegweisende Rolle, im Rahmen der klinisch‐pathologischen Korrelation, zukommt. In bisherigen Datenanalysen finden sich Hinweise, dass der MAR häufiger bei Patienten mit Sézary‐Syndrom auftritt und mit einem signifikant besseren Therapieansprechen einhergeht, weshalb die Abgrenzung von einem Krankheitsprogress besonders relevant ist. Die Behandlung des MAR erfolgt in Abhängigkeit vom Schweregrad, eine Pausierung der Therapie mit Mogamulizumab kann notwendig sein.Wir präsentieren drei Fälle aus unserer Klinik sowie den aktuellen Wissensstand der Literatur und möchten damit die hohe Relevanz der Kenntnis über den MAR im Management von Patienten mit kutanen Lymphomen aufzeigen.
Höhere intraoperative Detektionsraten malignitätsverdächtiger nichtpalpabler Läsionen durch Drahtmarkierung bei Patienten mit Hautkrebs
Authors: Tietze Julia K. , Emmert Steffen , Troitzsch Paulina , Rode Susen 
Published: August 2024

ZusammenfassungHintergrundKontrollierte Nachsorge bei Patienten nach vollständiger Resektion von Hochrisikotumoren der Haut führt zur Entdeckung von Metastasen in sehr frühen Stadien, allerdings ist die operative Entfernung nicht tastbarer Läsionen häufig problematisch.Patienten und MethodikIn dieser monozentrischen retrospektiven Studie wurden 39 Patienten mit malignen Hauttumoren mit verdächtigen nicht tastbaren Läsionen in Lymphknoten (90%) oder subkutan/intramuskulär (10%) eingeschlossen. Bei 21 Patienten wurden die Läsionen unter Ultraschallkontrolle exzidiert, 18 Patienten erhielten vor der Operation eine Drahtmarkierung. Die beiden Patientengruppen wurden hinsichtlich des erfolgreichen intraoperativen Auffindens der Läsion, der Dauer des Eingriffs und der Komplikationsrate verglichen.ErgebnisseDrahtmarkierung führte zu einer signifikant höheren intraoperativen Detektionsrate von 100% gegenüber 76% (p < 0,05). Die durchschnittlich benötigte Zeit für den gesamten Eingriff (p = 0,91) und die Komplikationsrate (p = 0,70) unterschieden sich nicht signifikant zwischen beiden Gruppen. Die mit Hilfe der Drahtmarkierung erfolgreich entfernten bösartigen Läsionen waren signifikant kleiner (p < 0,05). Von allen 34 operativ entfernten auffälligen Läsionen wurden nur 20 (59%) histologisch als bösartig bestätigt.SchlussfolgerungenDie Drahtmarkierung erhöhte die Detektionsrate nicht tastbarer verdächtiger subkutaner, intramuskulärer oder lymphatischer Läsionen. Sie führte zu früherer Diagnose der Metastasierung und auch zur Vermeidung unnötiger vollständiger Lymphknotendissektion.
Clinical and neuroimaging precursors in cerebral amyloid angiopathy: impact of the Boston criteria version 2.0
Authors: Weidauer Stefan , Tafreshi Mona , Förch Christian , Hattingen Elke , Arendt Christophe T. , Friedauer Lucie 
Published: August 2024

AbstractBackground and purposeAlthough the Boston criteria version 2.0 facilitates the sensitivity of cerebral amyloid angiopathy (CAA) diagnosis, there are only limited data about precursor symptoms. This study aimed to determine the impact of neurological and imaging features in relation to the time of CAA diagnosis.MethodsPatients diagnosed with probable CAA according to the Boston criteria version 1.5, treated between 2010 and 2020 in our neurocentre, were identified through a keyword search in our medical database. Neuroimaging was assessed using Boston criteria versions 1.5 and 2.0. Medical records with primary focus on the clinical course and the occurrence of transient focal neurological episodes were prospectively evaluated.ResultsThirty‐eight out of 81 patients (46.9%) exhibited transient focal neurological episodes, most often sensory (13.2%) or aphasic disorders (13.2%), or permanent deficits at a mean time interval of 31.1 months (SD ±26.3; range 1–108 months) before diagnosis of probable CAA (Boston criteria version 1.5). If using Boston criteria version 2.0, all patients receiving magnetic resonance imaging (MRI) met the criteria for probable CAA, and diagnosis could have been made on average 44 months earlier. Four patients were younger than 50 years, three of them with supporting pathology. Cognitive deficits were most common (34.6%) at the time of diagnosis.ConclusionsNon‐haemorrhagic MRI markers enhance the sensitivity of diagnosing probable CAA; however, further prospective studies are proposed to establish a minimum age for inclusion. As the neurological overture of CAA may occur several years before clinical diagnosis, early clarification by MRI including haemosensitive sequences are suggested.
Association of serum uric acid to serum creatinine ratio with 1‐year stroke outcomes in patients with acute ischemic stroke: A multicenter observational cohort study
Authors: Zhang Dandan , Liu Zhongzhong , Guo Weiyan , Lu Qingli , Lei Zhen , Liu Pei , Liu Tong , Peng Linna , Chang Qiaoqiao , Zhang Mi , Lin Xuemei , Wang Fang , Wu Songdi 
Published: August 2024

AbstractBackground and purposeConsidering the reliance of serum uric acid (SUA) levels on renal clearance function, its role in stroke outcomes remains controversial. This study investigated the association of renal function–normalized SUA (SUA to serum creatinine ratio, SUA/SCr), a novel renal function index, with the 1‐year outcomes in patients with acute ischemic stroke (AIS).MethodsThis is a prospective, multicenter observational study. Renal function–normalized SUA levels were determined by calculating the ratio of SUA to SCr. One‐year outcomes included stroke recurrence, all‐cause mortality, and poor prognosis. Multivariable Cox regression analyses and restriction cubic splines for curve fitting were used to evaluate SUA/SCr's association with 1‐year stroke outcomes.ResultsAmong 2294 enrolled patients, after adjustment for potential confounders, multivariable Cox regression analyses showed that each one‐unit increase in SUA/SCr corresponded to a 19% decrease in 1‐year stroke recurrence in patients with AIS. SUA/SCr was analyzed as a continuous variable and categorized into quartiles (Q1–Q4). Compared with the Q1 reference group, Q2, Q3, and Q4 showed significantly lower 1‐year stroke recurrence risks. The trend test indicated significant differences in the 1‐year stroke recurrence trend from Q1 to Q4. In these patients, SUA/SCr did not show a significant association with poor prognosis or all‐cause mortality. Curve fitting revealed SUA/SCr had a negative but nonlinear association with 1‐year stroke recurrence.ConclusionsIn patients with AIS, low SUA/SCr may be an independent risk factor for 1‐year stroke recurrence. Changes in SUA/SCr had no significant impact on 1‐year poor prognosis and all‐cause mortality.
Annual record on the number of general urological surgeries registered in the National Clinical Database system between April 2018 and December 2021 in Japan
Authors: Yasui Takahiro , Kikuchi Eiji , Yamamoto Hiroyuki , Ishii Daisuke , Mizuno Ryuichi , Hatakeyama Shingo , Kobayashi Takashi , Uchida Junji , Takahashi Masayuki , Sakamoto Shinichi , Morizane Shuichi , Kamoto Toshiyuki , Eto Masatoshi 
Published: August 2024

BackgroundThe Japanese National Clinical Database (NCD) is a large‐scale, nationwide, web‐based data entry system that covers the majority of surgical cases performed in Japan. An NCD specializing in urological surgery was launched based on the NCD system in 2018.MethodsAll urological surgeries performed at more than 1000 institutions were registered from 2018. We herein report the number of surgeries conducted as stipulated in the “Certified Urology Surgeon Training Curriculum” between April 2018 and December 2021.ResultsA total of 1 377 677 cases were registered from 1185 facilities nationwide under the initiative of the Japanese Urological Association. We examined the number of procedures performed every year for each of the 10 categories.ConclusionsThe NCD system sustainably provides important information relating to the preoperative status, operational outcome, and best practice for urological surgery in Japan.
An Interview With Peter Rousseeuw
Authors: Hubert Mia 
Published: August 2024

SummaryPeter J. Rousseeuw is a statistician known mainly for his work on robust statistics and cluster analysis. Among his creations are least trimmed squares regression, the minimum covariance determinant estimator, the partitioning around medoids clustering method and the silhouettes graphical display. Peter obtained his PhD in 1981 following research carried out at the ETH in Zürich, Switzerland, which led to a book on influence functions. Later, he was a professor at Delft University of Technology, The Netherlands, and at the University of Antwerp, Belgium. Next, he was a researcher at Renaissance Technologies in New York for over a decade. He then returned to Belgium as a full professor at KU Leuven, until becoming emeritus in 2022. He is an elected member of the International Statistical Institute and a fellow of the Institute of Mathematical Statistics and the American Statistical Association. In the course of his career, Peter published three books and over 200 papers, together receiving over 100 000 citations. He was awarded the George Box Medal for Business and Industrial Statistics, the Research Medal of the International Federation of Classification Societies, the Frank Wilcoxon Prize, and twice the Jack Youden Prize. Recently, Peter received the 2024 ASA Noether Distinguished Scholar Award for nonparametric statistics. His former PhD students include Annick Leroy, Rik Lopuhaä, Geert Molenberghs, Christophe Croux, Mia Hubert, Stefan Van Aelst, Tim Verdonck and Jakob Raymaekers. He is the creator and sole sponsor of the Rousseeuw Prize for Statistics, which was first handed out by the King of Belgium in 2022.
Combustion synthesis of tunable‐aspect‐ratio β‐Si3N4/BN composite ceramic materials
Authors: Meng Qing , He Gang , Yang Zengchao , Li Jiangtao 
Published: August 2024

AbstractHigh thermally conductive β‐Si3N4 is a new type of filler for thermally conductive materials. Tailoring its aspect ratio is crucial to optimize the preparation process and performance of polymer‐based thermal conductive materials. In this work, β‐Si3N4/BN thermally conductive hybrid fillers were prepared by combustion synthesis in a nitrogen atmosphere using low‐cost Si, B2O3 powders as raw materials, and the aspect ratio of β‐Si3N4 crystals were regulated according to the inhibiting growth strategy of second phase BN generated by in situ reaction. With the increase of B2O3, the content of BN increased slightly, while that of β‐Si3N4 decreased slightly. The aspect ratio of β‐Si3N4 decreased from 6.3 ± 1.9 to 1.9 ± 0.6, which might be ascribed to the inhibiting effect of BN sheets on the axial growth of rod‐like β‐Si3N4. Low‐aspect‐ratio β‐Si3N4/BN/epoxy composite exhibited high thermal conductivity of 1.04 W·m‐1·K‐1at the solid content of 50 wt%, which was 372.7% and 30.0% higher than that of neat epoxy and 40 wt% high‐aspect‐ratio β‐Si3N4/epoxy composite, respectively. In addition, β‐Si3N4/BN/epoxy composite also had good mechanical properties.
Ca3Sc2Si3O12:Ce3+, Mn2+ phosphor ceramic: A promising color converter for full‐color laser lighting
Authors: Wu Huajun , Xiao Han , Pan Guo‐Hui , Hao Zhendong , Zhang Liangliang , Wu Hao , Zhang Jiahua 
Published: August 2024

AbstractPhosphor ceramics are considered to be promising color converters for high‐brightness laser lighting. However, current laser lighting usually suffers from a poor color rendering index (Ra ∼70) when using a single‐structured phosphor ceramic, due to the deficiencies in the cyan‐green and red components of the luminescence spectra. In this study, a series of Ca3Sc2Si3O12:Ce3+, Mn2+ (CSS:Ce3+, Mn2+) phosphor ceramics were prepared for the first time using a solid‐state reaction method. Based on the efficient energy transfer from Ce3+ to Mn2+ (with an energy transfer efficiency of ∼33.3%), these ceramics exhibit three distinct emission peaks appearing at 505, 580, and 680 nm, covering the cyan‐green, yellow, and deep red‐light regions, respectively. Additionally, the ceramics display excellent thermal stability, with a thermal quenching temperature (T0.5) exceeding 160°C. Finally, a laser lighting source was constructed by combining the CSS:Ce3+, Mn2+ ceramic with a blue laser diode. By optimizing the Mn2+ concentration, a tunable color from cyan‐green to white was achieved, and the resulting Ra and luminous efficacy of the white light were 86 and 65 lm/W, respectively. These results demonstrate that the CSS:Ce3+, Mn2+ phosphor ceramic is an excellent color converter for full‐color laser lighting.
Stress–strain behavior of Cu on the AMB‐Si3N4 substrate undergoing thermal cycles via in situ strain measurement
Authors: Ngo Minh Chu , Miyazaki Hiroyuki , Hirao Kiyoshi , Ohji Tatsuki , Fukushima Manabu 
Published: August 2024

AbstractThe active metal brazing of a Si3N4 substrate with Cu has been evaluated for excellent reliability, demonstrating durability up to 1000 cycles in a cycling test ranging from −40°C to 250°C. While the finite element method (FEM) is commonly used for predicting thermal stress–strain in cyclic tests, experimental data on the measurement of thermal stress–strain on metallized substrates have remained limited. In this study, a digital image correlation (DIC) method was employed for the in situ measurement of thermal strain on a fully Cu‐coated Si3N4 substrate (AMB‐SN substrate) in various consecutive thermal cycles, ranging from 1–2 to 199–200. The thermal strains exhibited hysteresis curves that expanded slightly with cycles. By incorporating the coefficients of thermal expansion (CTE) of plain Cu and Si3N4, both the thermal stress and strain of Si3N4 and Cu on the AMB‐SN substrate were computed. The stress–strain curves of Cu revealed that the yield stress of Cu increased with the number of cycles, attributed to the cyclic hardening of the Cu layer. The Cu stress–strain curve calculated in this work showed a good agreement with the previous results obtained from compression/tension test of Cu at room temperature, which indicates the stress–strain curve of Cu on the composite was not sensitive to the temperature during the thermal cycle.
Machine‐learning interatomic potentials for pyrolysis of polysiloxanes and properties of SiCO ceramics
Authors: Falgoust Mitchell , Kroll Peter 
Published: August 2024

AbstractWe present machine‐learning interatomic potentials (MLIPs) for simulations of Si–C–O–H compounds. The MLIPs are constructed from moment tensor potentials (MTPs) and were trained to a library of configurations that included polysiloxane structures, hypothetical crystalline and amorphous SiCOH structures, and trajectories of Si–C–O–H systems obtained via ab initio molecular dynamic (aiMD) simulations at elevated temperatures. Passive, active, and hybrid learning strategies were implemented to develop the MLIPs. The MLIPs reproduce vibrational properties of polymers and SiCOH structures obtained from aiMD simulations, thus providing a tool to identify chemical units and distinct structural characteristics through their vibrational properties. Simulations of the polymer‐to‐ceramic transformation show the development of mixed tetrahedra in SiCO ceramics and align with experimental observations. Million‐atom simulations for several nanoseconds highlight the precipitation of graphitic nanosheets from a carbon‐rich SiCO precursor. Atomistic simulations with the MLIPs deliver details of chemical reaction mechanisms during the pyrolysis of polysiloxanes, including methane abstraction and Kumada‐like rearrangements that transform the siloxane backbone. While the MLIPs still leave room for systematic improvement, they deliver simulations with “density functional theory (DFT)‐like” quality at low and high temperatures.
Evaluation of community pharmacists' knowledge, practice and barriers towards diabetes management in Asir region, Saudi Arabia
Authors: Salem Heba H. , Bazan Naglaa S. , Addal Waad Al , Alkhmash Mona , Bana Mashael Abu , Al Awad Sumayah M. , Asiri Hind S. , Alwadei Samar D. , Khaled Arwa 
Published: August 2024

AbstractRationale, Aims and ObjectivesDiabetes mellitus is a global serious health problem that has a clear negative impact on economy. The high prevalence of diabetes worldwide urges for prevention and educational programs. Engagement of community pharmacists in offering various diabetes care services enables delivery of quality of care for patients and could play key role in diabetes management. The current study was designed to assess the knowledge towards diabetes among community pharmacists and to investigate their role in diabetes management through identifying different diabetes care services they provide in Asir region, Saudi Arabia. In addition, possible barriers for providing these services were evaluated.MethodA cross‐sectional study was performed using an online self‐administered anonymous survey that consisted of 4 domains: demographics, knowledge, practice and barriers related to diabetes management.ResultsA total of 258 pharmacists completed the survey, and one‐third of respondents (34.5%) demonstrated good knowledge while 42.2% showed moderate knowledge towards diabetes. Respondents of the age group (30–39) years, males, those with bachelor's degree and those with 5 years or less of experience had higher mean knowledge. Nearly half of the participants had positive practice. The most prominent (75%) services offered by the community pharmacists were counselling on the appropriate administration, handling and storage of insulin and the appropriate time to administer oral antidiabetic drugs. Pharmacists who received training had higher mean practice scores. Lack of time, lack of diabetic patients visiting the pharmacy and low patient expectations regarding pharmacists' role in diabetes care were identified as the most important barriers they encountered.ConclusionCommunity pharmacists of Asir region exhibited moderate knowledge and practices regarding diabetes management. Our results support the need for national advanced diabetes training programs targeting community pharmacists for providing quality of care services for diabetic patients Moreover, strategies to overcome the reported barriers are indispensable.
Characterising repetitive behaviours in children and adolescents with Down syndrome
Authors: Fucà E. , Costanzo F. , Vicari S. 
Published: August 2024

AbstractBackgroundIndividuals with intellectual disability, including people with Down syndrome (DS), often exhibit restricted and repetitive behaviours (RRBs). However, RRBs have not been deeply characterised in children and adolescents with DS.MethodThe study encompassed a cohort of 151 participants aged 4 to 18 years with DS. RRBs were assessed utilising the Repetitive Behaviour Scale‐Revised. Additionally, data pertaining to cognitive and adaptive functioning, linguistic abilities, sleep patterns and emotional/behavioural issues were gathered.ResultsSelf‐injurious behaviours were reported less frequently whereas parents most commonly endorsed items related to behaviours associated with the need for sameness and ritualistic behaviours. We observed very few gender differences, whereas some age‐related differences emerged, with adolescents exhibiting higher scores in items related with higher‐level RRBs. The analysis of the association between RRBs and clinical features revealed that RRBs were associated with parent‐reported sleep difficulties, as well as with internalising and externalising problems. We also observed a negative correlation with IQ whereas associations with adaptive skills emerged mainly for lower‐level RRBs, such as motor stereotypies. Finally, RRBs were negatively associated with linguistic abilities, both expressive and receptive.ConclusionsRRBs in children and adolescents with DS are of significant clinical interest due to their associations with various clinical dimensions. Therefore, psychological and neuropsychiatric assessment should include an accurate evaluation of RRBs for young people with DS.