bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allograft Reconstruction of Chronic Tibialis Anterior Tendon Ruptures
Authors: Huh Jeannie , Boyette Deanna M. , Parekh Selene G. , Nunley James A. 
Published: June 2015

Background: Chronic ruptures of the tibialis anterior tendon are often associated with tendon retraction and poor-quality tissue, resulting in large segmental defects that make end-to-end repair impossible. Interpositional allograft reconstruction has previously been described as an operative option in these cases; however, there are no reports of the clinical outcomes of this technique in the literature. Methods: Eleven patients with chronic tibialis anterior tendon ruptures underwent intercalary allograft recon-struction between 2006 and 2013. Patient demographics, injury presentation, and details of surgery were reviewed. Postoperative outcomes at a mean follow-up of 43.8 (range, 6-105) months included the American Orthopaedic Foot & Ankle Society (AOFAS) Ankle-Hindfoot score, Short Form–12 (SF-12) physical health score, Lower Extremity Functional Score (LEFS), visual analog scale (VAS) pain rating, dorsiflexion strength, gait analysis, and complications. Results: The average postoperative dorsiflexion strength, as categorized by the Medical Council grading scale, was 4.8 ± 0.45. The average postoperative VAS score was 0.8 ± 1.1. The average LEFS was 66.9 ± 17.2, SF-12 physical health score was 40.1 ± 14.4, and AOFAS score was 84.3 ± 7.7. One complication occurred, consisting of transient neuritic pain in the superficial peroneal nerve distribution. There were no postoperative infections, tendon reruptures, reoperations, or allograft-associated complications. Conclusion: Allograft reconstruction of chronic irreparable tibialis anterior tendon ruptures yielded satisfactory strength, pain, and patient-reported functional outcomes. This technique offers a safe and reliable alternative, without the donor site morbidity associated with tendon transfer or autograft harvest. Level of Evidence: Level IV, retrospective case series.
Clinical safety of robenacoxib in feline osteoarthritis: results of a randomized, blinded, placebo-controlled clinical trial
Authors: King Jonathan N , King Stephen , Budsberg Steven C , Lascelles B Duncan X , Bienhoff Stephen E , Roycroft Linda M , Roberts Elizabeth S 
Published: June 2015

Objectives The objective of this study was to evaluate the clinical safety of the non-steroidal anti-inflammatory drug (NSAID) robenacoxib in cats with osteoarthritis. Degenerative joint disease, including osteoarthritis, is highly prevalent in cats and many cases have associated pain and impaired mobility. Although NSAIDs are used routinely to control pain and inflammation in cats with osteoarthritis, there are safety concerns because of the high concurrent prevalence of chronic kidney disease (CKD) and the paucity of data on the safety of these drugs in target clinical populations. Methods A total of 194 cats with osteoarthritis were recruited and randomly allocated to receive either robenacoxib at a dosage of 1.0–2.4 mg/kg (n = 95) or placebo (n = 99) tablets PO q24h for 28 days. Safety was assessed in 193 cats, including a subgroup of 40 animals with concurrent CKD, defined as serum creatinine concentration ⩾1.6 mg/dl and urine specific gravity <1.030. Safety endpoints included reports of adverse events, results of clinical examinations, including body weight, and clinical chemistry and hematology variables. Results In all 193 cats and the subgroup of 40 animals with concurrent CKD, there were no differences between groups in frequencies of reported adverse events, body weight change or results of serum or urine chemistry or hematology variables. Conclusions and relevance Robenacoxib was well tolerated when administered daily for 1 month in cats with osteoarthritis, including cats with evidence of concurrent CKD. There was no clinical indication of damage to the gastrointestinal tract, kidney or liver.
Functional connectivity changes and their relationship with clinical disability and white matter integrity in patients with relapsing–remitting multiple sclerosis
Authors: Sbardella Emilia , Tona F , Petsas N , Upadhyay N , Piattella MC , Filippini N , Prosperini L , Pozzilli C , Pantano P 
Published: June 2015

Background and objective: To define the pathological substrate underlying disability in multiple sclerosis by evaluating the relationship of resting-state functional connectivity with microstructural brain damage, as assessed by diffusion tensor imaging, and clinical impairments. Methods: Thirty relapsing–remitting patients and 24 controls underwent 3T-MRI; motor abilities were evaluated by using measures of walking speed, hand dexterity and balance capability, while information processing speed was evaluated by a paced auditory serial addiction task. Independent component analysis and tract-based spatial statistics were applied to RS-fMRI and diffusion tensor imaging data using FSL software. Group differences, after dual regression, and clinical correlations were modelled with General-Linear-Model and corrected for multiple comparisons. Results: Patients showed decreased functional connectivity in 5 of 11 resting-state-networks (cerebellar, executive-control, medial-visual, basal ganglia and sensorimotor), changes in inter-network correlations and widespread white matter microstructural damage. In multiple sclerosis, corpus callosum microstructural damage positively correlated with functional connectivity in cerebellar and auditory networks. Moreover, functional connectivity within the medial-visual network inversely correlated with information processing speed. White matter widespread microstructural damage inversely correlated with both the paced auditory serial addiction task and hand dexterity. Conclusions: Despite the within-network functional connectivity decrease and the widespread microstructural damage, the inter-network functional connectivity changes suggest a global brain functional rearrangement in multiple sclerosis. The correlation between functional connectivity alterations and callosal damage uncovers a link between functional and structural connectivity. Finally, functional connectivity abnormalities affect information processing speed rather than motor abilities.
Comparative analysis of treatment outcomes in patients with neuromyelitis optica spectrum disorder using multifaceted endpoints
Authors: Jeong In Hye , Park Boram , Kim Su-Hyun , Hyun Jae-Won , Joo Jungnam , Kim Ho Jin 
Published: June 2015

Background: There is still an unmet need for comparative analyses of available treatment options for neuromyelitis optica spectrum disorder (NMOSD). Objective: We aimed to compare the efficacies of the immunosuppressants most commonly prescribed for patients with NMOSD using multifaceted endpoints. Methods: We conducted a retrospective analysis of treatment outcomes in 138 NMOSD patients treated with azathioprine, mycophenolate mofetil (MMF), or rituximab. The primary outcome measures were the annualized relapse rate (ARR), annualized severe relapse rate, time to first relapse, and time to first severe relapse. Results: A comparison of any relapse among the groups revealed that the azathioprine had a significantly higher risk of relapse relative to the rituximab (hazard ratio: 1.82; 95% CI: 1.1–3.1; p=0.03). A comparison of severe relapse among the groups revealed that the hazard ratios of severe relapse for the azathioprine and MMF relative to the rituximab were 11.66 (95% CI: 2.6–52.3; p=0.001) and 5.96 (95% CI: 1.0–35.1; p=0.048), respectively. The times to first relapse and first severe relapse were also significantly different among the treatment groups Conclusions: The present study showed that reductions in the risks of relapse and severe relapse differed among patients who were initially treated with azathioprine, MMF, and rituximab.
Symptoms of posttraumatic stress disorder, anxiety and depression among Czech critical care and general surgical and medical ward nurses
Authors: Janda Robert , Jandová Eva 
Published: June 2015

Purpose Our aim was to determine the occurrence of posttraumatic symptoms and symptoms of anxiety and depression among nurses in a Czech tertiary hospital. In addition, we attempted to explore the relationship between stressful work factors, work overload and disturbed interpersonal relationships, and the appearance of their symptoms. Methods Nurses received an anonymous three-part questionnaire including PTSS-10 and HADS inventories. Results In the case of general nurses the most prevalent symptoms were of anxiety (44%), followed by symptoms of depression (15%) and then posttraumatic stress disorder (PTSD) (7%). Similarly, for intensive care unit (ICU) nurses anxiety symptoms were the most prevalent (28%), followed by symptoms of depression (15%) and PTSD (3%). We identified certain specific traumatic factors present in particular workplaces (care for dying patients and the bodies of the deceased, and participation in cardiopulmonary resuscitation, all found in general units, and care for potential organ donors in ICUs). General nurses were less satisfied with their job and their workload was high. It seems that in both workplaces, the occurrence of symptoms of anxiety best correlated with several estimated markers of high workload. Conclusion The study revealed a high incidence of symptoms of anxiety, especially in general nurses, and it pointed to the low incidence of symptoms of PTSD. Our results are not in accordance with the conclusions of some studies published on this topic.
Biologics in inflammatory bowel disease: what are the data?
Authors: Côté-Daigneault Justin , Bouin Mickael , Lahaie Raymond , Colombel Jean-Frédéric , Poitras Pierre 
Published: June 2015

BackgroundOver the last decade, biologics have gained an important place for the treatment of moderate to severe inflammatory bowel disease (IBD), and many randomized control trials have evaluated their efficacy.AimThe goal of this review is to analyze the results of these trials and to highlight the evidence and indications emerging from these studies for their implementation in the management of IBD patients.MethodsA PubMed search was realized to screen high‐quality clinical trials studying biologic agents currently available in clinics for the treatment of IBD. Words used were: “infliximab,” “adalimumab,” “certolizumab,” “golimumab,” “natalizumab,” “vedolizumab,” “ustekinumab,” “azathioprine,” “methotrexate,” “Crohn's disease,” and “ulcerative colitis.”ResultsIn Crohn's disease, studies supporting induction and maintenance therapies were documented for infliximab, adalimumab, certolizumab, natalizumab, vedolizumab, and ustekinumab. Infliximab, adalimumab, and certolizumab have evidences for fistulizing Crohn's disease and only infliximab and adalimumab have evidences for mucosal healing. In ulcerative colitis, studies supporting induction, maintenance, and mucosal healing were found with infliximab, adalimumab, golimumab, and vedolizumab. Only infliximab was associated with evidences for combination therapy with thiopurine and acute severe colitis in ulcerative colitis.ConclusionManagement with biologics in IBD patients is well validated by high‐quality clinical trials.
New role for the (pro)renin receptor in T-cell development
Authors: Geisberger Sabrina , Maschke Ulrike , Gebhardt Matthias , Kleinewietfeld Markus , Manzel Arndt , Linker Ralf A. , Chidgey Ann , Dechend Ralf , Nguyen Genevieve , Daumke Oliver , Muller Dominik N. , Wright Mark D. , Binger Katrina J. 
Published: June 2015

Key Points
PRR deletion in T cells drastically reduces the number of peripheral and thymic CD3+ T cells. We identify multiple stages of thymocyte development that require PRR expression.
Effect of Extra-Framework Cations of LTL Nanozeolites to Inhibit Oil Oxidation
Authors: Tan Kok-Hou , Cham Hooi-Ying , Awala Hussein , Ling Tau Chuan , Mukti Rino R , Wong Ka-Lun , Mintova Svetlana , Ng Eng-Poh 
Published: June 2015

Abstract
Lubricant oils take significant part in current health and environmental considerations since they are an integral and indispensable component of modern technology. Antioxidants are probably the most important additives used in oils because oxidative deterioration plays a major role in oil degradation. Zeolite nanoparticles (NPs) have been proven as another option as green antioxidants in oil formulation. The anti-oxidative behavior of zeolite NPs is obvious; however, the phenomenon is still under investigation. Herein, a study of the effect of extra-framework cations stabilized on Linde Type L (LTL) zeolite NPs (ca. 20 nm) on inhibition of oxidation in palm oil-based lubricant oil is reported. Hydrophilic LTL zeolites with a Si/Al ratio of 3.2 containing four different inorganic cations (Li+, Na+, K+, Ca2+) were applied. The oxidation of the lubricant oil was followed by visual observation, colorimetry, fourier transform infrared (FTIR) spectroscopy, 1H NMR spectroscopy, total acid number (TAN), and rheology analyses. The effect of extra-framework cations to slow down the rate of oil oxidation and to control the viscosity of oil is demonstrated. The degradation rate of the lubricant oil samples is decreased considerably as the polarizability of cation is increased with the presence of zeolite NPs. More importantly, the microporous zeolite NPs have a great influence in halting the steps that lead to the polymerization of the oils and thus increasing the lifetime of oils.
Antioxidative effects of cerium dioxide nanoparticles ameliorate age-related male infertility: optimistic results in rats and the review of clinical clues for integrative concept of men health and fertility
Authors: Kobyliak Nazarii M. , Falalyeyeva Tetyana M. , Kuryk Olena G. , Beregova Tetyana V. , Bodnar Petro M. , Zholobak Nadiya M. , Shcherbakov Oleksandr B. , Bubnov Rostyslav V. , Spivak Mykola Ya 
Published: June 2015

AbstractBackgroundMale infertility has largely idiopathic, multifactorial origin. Oxidative stress is a major factor that affects spermatogenesis, in particular in aging. Cerium dioxide nanoparticles (CNPs) due to their antioxidative properties are promising to impact on the development of male infertility.The aimsof this study were to investigate the effects of CNPs on fertility parameters in 24-month male rats and to overview relevant literature in the field of personalized treatments, predictive diagnosis, and preventive measures for male health and fertility.MethodsWe included 30 24-month-old male rats. After a week of adaptation to the standard diet, the rats were randomly divided into three groups with ten rats in each. Group 1 (controls) received only a standard diet. The rats of group 2 and 3 in adjunct to the standard diet during 10 days received intragastrically 10 % sodium citrate and citrate-coated CNPs in dose 1 mg/kg, respectively. We assessed sex hormones, epididymal sperm parameters and spermatogenesis, ultrasound, and morphological data of rat reproductive organs.ResultsAfter a 10-day administration of CNPs, we revealed significant decrease of lipid peroxidation product levels in serum and increase of catalase and SOD activity, associated with increase of sperm count (p< 0.001) and improvement in quantitative sperm parameters (motility, viability, and percentage of spermatozoa). We found no significant changes between sperm quantitative parameters in citrate-treated rats and controls and observed age-related decrease of activated Leydig cell number and focal atrophy of the seminiferous tubules. In CNP group, we observed regeneration of seminiferous tubules, increase number and activation of Leydig cells, and 2.5-fold significant increase of serum testosterone. Ultrasound data showed the slight increase of linear measurement and volume of rat testes in CNP group. Review highlights the benefits for predictive diagnosis, preventive measures, and personalized approaches to manage male infertility in the general concept of male health also related to aging.ConclusionCitrate-coated 2–5-nm CNPs lead to increase in sex hormones levels, sperm count, and quality, as well as the activation of spermatogenesis in 24-month-old male rats. Nanoceria demonstrated the perspectives to be an effective infertility treatment via reduction of oxidative stress in male reproductive organs, in particular in aging.
The impact of repeated autologous infusion of haematopoietic stem cells in patients with liver insufficiency
Authors: Zekri Abdel-Rahman N. , Salama Hosny , Medhat Eman , Musa Sherief , Abdel-Haleem Hanan , Ahmed Ola S. , Khedr Hanan Abdel Hafez , Lotfy Mai M. , Zachariah Khaled S. , Bahnassy Abeer A. 
Published: June 2015

Abstract
Introduction
The worldwide shortage of donor livers has prompted the search for alternative cell therapies. Previous data from our laboratory proved a supportive role for stem cell therapy in the treatment of end-stage liver disease patients. Therefore; this study was conducted to assess the clinical and biochemical effects of repeated stem cell infusion.

Methods
Ninety patients with liver cirrhosis were randomized to receive either one session treatment (G-I) or two sessions 4 months apart (G-II) of autologous haematopoietic stem cells (HSCs) transplantation and a control group (G-III) who received regular liver treatment. G-CSF was administered to transplanted patients before infusion; HSCs were isolated from 400 cc bone marrow (BM) aspirate. CD34+/CD133+ cells were purified: 50 % of the cells were infused locally in the portal vein on the same day and the other 50 % were differentiated to MSC and infused systemically in a peripheral vein (one session treatment G-I). In G-II, the same process was repeated after 4 months from the first treatment (two session’s treatment G-II). Liver function was monitored for 12 months after stem cell therapy (SCT).

Results
Statistically significant improvement was reported in the transplanted patients (G-1) as regards the mean serum albumin, bilirubin and INR levels which started to improve after 2 weeks of treatment and continued to improve till the 6th month in the single infusion group. The two sessions infused group (G-II) showed sustained response which continued throughout the all follow-up period (12 month). By the end of the study, 36.7 % of the patients in G-I and 66.7 % in G-II showed improvement in the degree of ascites compared to the control group (G-III). We also reported an improvement in the hepatic functional reserve as assessed by the Child-Pugh and MELD score. Safety of the procedure was evidenced by the low incidence of complications encountered.

Conclusion
In patients with end-stage liver disease, the repeated infusion with combined routes portal and peripheral veins has a beneficial effect on liver functions with minimal adverse events and more lasting clinical efficacy after repeated HSCs infusion.
Mesenchymal stem cell therapy for doxorubicin cardiomyopathy: hopes and fears
Authors: Ezquer Fernando , Gutiérrez Jaime , Ezquer Marcelo , Caglevic Christian , Salgado Helio C , Calligaris Sebastián D 
Published: June 2015

AbstractChemotherapy has made an essential contribution to cancer treatment in recent decades despite its adverse effects. As cancer survivors have increased, concern about ex-patient lifespan has become more important too. Doxorubicin is an effective anti-neoplastic drug that produces a cardiotoxic effect. Cancer survivors who received doxorubicin became more vulnerable to cardiac disease than the normal population did. Many efforts have been made to prevent cardiac toxicity in patients with cancer. However, current therapies cannot guarantee permanent cardiac protection. One of their main limitations is that they do not promote myocardium regeneration. In this review, we summarize and discuss the promising use of mesenchymal stem cells for cardio-protection or cardio-regeneration therapies and consider their regenerative potential without leaving aside their controversial effects on tumor progression.
Radiosynthesis and first preclinical evaluation of the novel norepinephrine transporter pet-ligand [11C]ME@HAPTHI
Authors: Rami-Mark Christina , Berroterán-Infante Neydher , Philippe Cecile , Foltin Stefanie , Vraka Chrysoula , Hoepping Alexander , Lanzenberger Rupert , Hacker Marcus , Mitterhauser Markus , Wadsak Wolfgang 
Published: June 2015

Abstract

Background
The norepinephrine transporter (NET) has been demonstrated to be relevant to a multitude of neurological, psychiatric and cardiovascular pathologies. Due to the wide range of possible applications for PET imaging of the NET together with the limitations of currently available radioligands, novel PET tracers for imaging of the cerebral NET with improved pharmacological and pharmacodynamic properties are needed.

Methods
The present study addresses the radiosynthesis and first preclinical evaluation of the novel NET PET tracer [11C]Me@HAPTHI by describing its affinity, selectivity, metabolic stability, plasma free fraction, blood–brain barrier (BBB) penetration and binding behaviour in in vitro autoradiography.

Results
[11C]Me@HAPTHI was prepared and displayed outstanding affinity and selectivity as well as excellent in vitro metabolic stability, and it is likely to penetrate the BBB. Moreover, selective NET binding in in vitro autoradiography was observed in human brain and rat heart tissue samples.

Conclusions
All preclinical results and radiosynthetic key-parameters indicate that the novel benzothiadiazole dioxide-based PET tracer [11C]Me@HAPTHI is a feasible and improved NET radioligand and might prospectively facilitate clinical NET imaging.
Aspirations, challenges, and open issues for software-based 5G networks in extremely dense and heterogeneous scenarios
Authors: M. Borges Vinicius C. , Cardoso Kleber Vieira , Cerqueira Eduardo , Nogueira Michele , Santos Aldri 
Published: June 2015

AbstractAn upsurge of heterogeneous wireless devices and wide-ranging applications on extremely dense urban scenarios has led to challenging conditions that cannot be easily handled by 4G systems, such as the inefficient use of the frequency spectrum and the high energy consumption. In order to address those challenges, the 5G system design demands new architectures to cope with specific requirements, such as scalability, resilience, and energy efficiency. These requirements play a fundamental role in extremely dense scenarios. In addition, when jointly addressed, they have distinct priorities depending mainly on the specific user application demands. In this context, this article presents a management architecture for 5G system, called Wireless Software-basEd architecture for Extremely Dense networks (WiSEED). It is grounded on a software-based perspective of management and jointly manages three key operational services, as follows: routing, mobility, and spectrum usage. Such perspective of management is possible due to programmable network technologies, i.e., network function virtualization and software-defined networking. The architecture mainly intends to provide a better trade-off between the 5G requirements themselves and a high quality ubiquitous and seamless services, as well as efficient mobile broadband Internet for end users. Trace-driven simulation results from a case study show improvements when the management architecture is employed over conflicting requirements.