bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spindle cell thymomas with neuroendocrine morphology: a clinicopathological and immunohistochemical study of 18 cases
Authors: Weissferdt Annikka , Moran Cesar A 
Published: April 2014

AimsTo present 18 cases of spindle cell thymoma (WHO type A) with prominent neuroendocrine morphology.Methods and resultsThe patients were nine men and nine women aged 36–76 years (average: 56 years). Clinically, the patients presented with non‐specific symptoms such as chest pain, or were entirely asymptomatic. None of the patients had a history of autoimmune syndrome. Surgical resection was performed in all patients. The tumour size ranged from 30 to 110 mm. Macroscopically, the tumours were described as light brown or tan masses with a homogeneous and solid appearance. Microscopically, all tumours showed areas that closely resembled the typical growth pattern of neuroendocrine tumours, i.e. rosette‐like structures or a trabecular, insular or ribbon‐like arrangement of tumour cells. Areas of more conventional spindle cell thymoma were present in all cases. Seven cases were encapsulated, and 10 cases were invasive tumours. Immunohistochemically, the tumours were positive for pancytokeratin but negative for synaptophysin and chromogranin A. Follow‐up information for 10 patients showed that all patients were alive after a period ranging from 1 month to 6 years.ConclusionsFamiliarity with this particular pattern of thymoma is important in order to separate this tumour from true neuroendocrine carcinoma and prevent unnecessary adjuvant treatment.
Acute leukemia detection rate by automated blood count parameters and peripheral smear review
Authors: Rabizadeh E. , Pickholtz I. , Barak M. , Isakov E. , Zimra Y. , Froom P. 
Published: April 2014

SummaryIntroductionIt is unclear what minimal criteria will identify all new cases of acute leukemia in adults in various settings.MethodsTo determine the adult acute leukemia detection rate of the various criteria, we recorded complete blood count (CBC) test results from consecutive patients with leukemia (130 hospitalized patients and 96 outpatients) and from consecutive patients without leukemia (34 827 hospitalized and 33 695 outpatients).ResultsBasic criteria for a reflex review (hemoglobin, platelets, and a five‐part differential) detected 91% of new hospital leukemia patients (118 of 130) compared to 75% (72 of 96) outpatients. No cases were missed if we did reflex testing when there was either one of the basic criteria or an increased proportion of large unstained cells (LUC), but five cases were missed using the blast flag instead of the LUC. Adding the LUC to basic criteria resulted in the detection of all cases of acute leukemia. The cost of detection of one case of acute leukemia was 1029 and 425 peripheral smear reviews in hospital and outpatients, respectively.ConclusionWe conclude that basic criteria available on most hematology analyzers along with the LUC identify all adult patients with acute leukemia in both hospital and outpatient settings with minimal peripheral smear review rates.
Less Invasive Unilateral Arytenoid Lateralization: A Modified Technique for Treatment of Idiopathic Laryngeal Paralysis in Dogs: Technique Description and Outcome
Authors: von Pfeil Dirsko J. F. , Edwards Michael R. , Déjardin Loïc M. 
Published: April 2014

ObjectiveTo (1) describe a modification of conventional unilateral cricoarytenoid lateralization (UCAL), called less‐invasive unilateral cricoarytenoid lateralization (LI‐UCAL) for treatment of idiopathic laryngeal paralysis (LP); (2) report clinical outcome of LI‐UCAL; and (3) describe the effect of early discharge after surgery.Study DesignRetrospective clinical study.AnimalsDogs (n = 22).MethodsMedical records (January 2009 to October 2011) of dogs diagnosed with idiopathic LP that had LI‐UCAL were reviewed. Signalment, clinical signs, laboratory tests, imaging, concurrent medical conditions, information from the anesthesia record, and hospitalization time were documented. Follow‐up was obtained by direct examination, questionnaire, and review of medical records from referring veterinarians.ResultsDogs included in the study had variable degrees and duration of respiratory distress before surgery. Median surgery time was 32 minutes. Median hospitalization was 6 hours, and median follow‐up was 427 days. Long‐term respiratory function, as reported by owners at last follow‐up, improved in 95.5% of dogs after surgery; exercise tolerance improved by 90%. Major complications included death secondary to aspiration pneumonia (9%), aspiration pneumonia from which dogs recovered within 3 days after administration of antimicrobials (9%), and development of right‐sided laryngeal collapse that required right sided LI‐UCAL (4.5%). At long‐term follow‐up, 95.5% of owners were satisfied with the surgical outcome.ConclusionLI‐UCAL is a feasible surgical technique and resulted in improvement of clinical signs related to LP. Calm recoveries without adverse effects such as respiratory distress were associated with early discharge. LI‐UCAL could be considered an alternative to conventional UCAL.
Hip Toggle Stabilization Using the TightRope® System in 17 Dogs: Technique and Long‐Term Outcome
Authors: Kieves Nina R. , Lotsikas Peter J. , Schulz Kurt S. , Canapp Sherman O. 
Published: April 2014

ObjectiveTo describe the technique for, and long‐term clinical outcome of, a modified hip toggle stabilization using the TightRope® system for coxofemoral luxation repair.Study DesignRetrospective case series.MethodsMedical records (July 2008–July 2010) including radiographs (17 limbs) of dogs that had coxofemoral luxation repaired with the TightRope system were reviewed. Follow‐up (≥12 months) was obtained by telephone interview of owners. Six dogs were available for re‐evaluation, radiographs, and objective gait analysis.ResultsFollow‐up (mean, 24 months; range, 12–43 months) by telephone interview was available for 17 dogs. Of these, 6 dogs were re‐evaluated (mean, 7.5 months; median 12.5 months: range, 4–24 months) and had gait analysis. Mean duration of luxation before surgical intervention was 7.5 days (median, 7 days; range, 2–44 days). There was a single case of relaxation 27 months postoperatively. One dog died from non‐surgical related circumstances. Objective gait analysis showed equal pelvic limb use in all 6 dogs available for re‐evaluation. All owners of living dogs reported limb function as being good to excellent, and perceived that their dogs were pain free. Radiographs (mean, 7.5 months; median, 12.5 months; range, 4–24 months post surgery) of 6 dogs showed no progression of osteoarthritis in comparison to immediate postoperative radiographs.ConclusionsHip toggle with the TightRope system as a prosthetic ligament of the head of the femur produces a favorable clinical outcome with high owner acceptance.
Comparing the monitoring of patients transferred from a critical care unit to hospital wards at after‐hours with day transfers: an exploratory, prospective cohort study
Authors: Wood Sally D. , Coster Samantha , Norman Ian 
Published: April 2014

AbstractAimsTo investigate possible factors related to patient monitoring to explain the higher mortality rates associated with after‐hours transfers compared with daytime transfers from critical care units to the wards.BackgroundInternational research suggests that patients transferred from critical care units after‐hours have a higher mortality rate than transfers during daytime, although the reasons remain unknown.DesignA prospective exploratory study.MethodsTwenty‐nine patients transferred from a UK critical care unit to a ward within the same hospital after‐hours for 10 weeks beginning April 2009 were compared with 29 transfers during daytime hours matched on potentially confounding characteristics. UK Critical Care Unit transfer guidelines have remained unchanged since data collection. Outcomes were as follows: (i) frequency of nursing observations; (ii) time periods from transfer to first medical review; (iii) time period from transfer to first clinical observations; (iv) frequency of transfer to an inappropriate ward; (v) delayed transfers from Critical Care Unit to ward.ResultsUsing Wilcoxon's Rank test (two tail) to compare paired data from the matched groups, observations were recorded significantly less frequently within the first 12 hours for after‐hours transfers. Time from transfer to first clinical observations was significantly longer for after‐hour transfer patients. The delay from when the patient was ready for ward care and actual transfer was also longer for the after‐hours transfer group.ConclusionsSurveillance differences, including time to the first set of observations and frequency of observations in the first 12 hours, are potential factors that may explain the differential mortality associated with after‐hours transfers.
SWATmodel: A Multi‐Operating System, Multi‐Platform SWAT Model Package in R
Authors: Fuka Daniel R. , Walter M. Todd , MacAlister Charlotte , Steenhuis Tammo S. , Easton Zachary M. 
Published: April 2014

AbstractThe Soil and Water Assessment Tool (SWAT) model (Arnold et al., 1998) is a popular watershed management tool. Currently, the SWAT model, actively supported by the U.S. Department of Agriculture and Texas A&M, operates only on Microsoft® Windows, which hinders modelers that use other operating systems (OS). This technical note introduces the Comprehensive R Archive Network (CRAN) distributed “SWATmodel” package which allows SWAT 2005 and 2012 to be widely distributed and run as a linear model‐like function on multiple OS and processor platforms. This allows researchers anywhere in the world using virtually any OS to run SWAT. In addition to simplifying the use of SWAT across computational platforms, the SWATmodel package allows SWAT modelers to utilize the analytical capabilities, statistical libraries, modeling tools, and programming flexibility inherent to R. The software allows watershed modelers to develop a simple hydrological watershed model conceptualization of the SWAT model and to obtain a first approximation of the minimum expected results a more complicated model should deliver. As a proof of concept, we test the SWAT model by initializing and calibrating 314 U.S. Geological Survey stream gages in the Chesapeake Bay watershed and present the results.
SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis
Authors: de Jong Thijs M. H. , Jochens Arne , Jockel‐Schneider Yvonne , Harks Inga , Dommisch Henrik , Graetz Christian , Flachsbart Friederike , Staufenbiel Ingmar , Eberhard Jörg , Folwaczny Mathias , Noack Barbara , Meyle Joerg , Eickholz Peter , Gieger Christian , Grallert Harald , Lieb Wolfgang , Franke Andre , Nebel Almut , Schreiber Stefan , Doerfer Christof , Jepsen Søren , Bruckmann Corinna , van der Velden Ubele , Loos Bruno G. , Schaefer Arne S. 
Published: April 2014

AbstractAimIdentification of variants within genes SLC23A1 and SLC23A2 coding for vitamin C transporter proteins associated with aggressive (AgP) and chronic periodontitis (CP).Material and MethodsEmployment of three independent case–control samples of AgP (I. 283 cases, 979 controls; II. 417 cases, 1912 controls; III. 164 cases, 357 controls) and one sample of CP (1359 cases, 1296 controls).ResultsStage 1: Among the tested single‐nucleotide polymorphisms (SNPs), the rare allele (RA) of rs6596473 in SLC23A1 showed nominal significant association with AgP (p = 0.026, odds ratio [OR] 1.26, and a highly similar minor allele frequency between different control panels. Stage 2: rs6596473 showed no significant association with AgP in the replication with the German and Dutch case–control samples. After pooling the German AgP populations (674 cases, 2891 controls) to significantly increase the statistical power (SP = 0.81), rs6596473 RA showed significant association with AgP prior to and upon adjustment with the covariates smoking and gender with padj = 0.005, OR = 1.35. Stage 3: RA of rs6596473 showed no significant association with severe CP.ConclusionSNP rs6596473 of SLC23A1 is suggested to be associated with AgP. These results add to previous reports that vitamin C plays a role in the pathogenesis of periodontitis.
Levodopa‐Responsive Hemiparkinsonism Secondary to Cystic Expansion from a Coiled Cerebral Aneurysm
Authors: Norris Scott A. , Derdeyn Colin P. , Perlmutter Joel S. 
Published: April 2014

ABSTRACTAn 80‐year‐old woman with longstanding hemifacial spasm had a 1 cm × 1.5 cm internal carotid artery terminus aneurysm treated with endovascularly delivered bare metal coils. Follow‐up imaging revealed an expansile perianeurysmal cyst that coincided with development of contralateral dopa‐responsive hemiparkinsonism. This is the first report of perianeurysmal cyst expansion causing levodopa‐responsive hemiparkinsonism.
Antioxidant enzyme activities, plasma hormone levels and serum metabolites of finishing broiler chickens reared under high ambient temperature and fed lemon and orange peel extracts and Curcuma xanthorrhiza essential oil
Authors: Akbarian A. , Golian A. , Kermanshahi H. , De Smet S. , Michiels J. 
Published: April 2014

SummaryThe negative effects of high ambient temperature during some months of the year on poultry production have been of great concern in many countries. Dietary modifications are among the most practical ways to alleviate the effects of high temperature. Possible effects of dietary supplementation with 200 or 400 mg/kg feed of lemon peel extract (LPE), orange peel extract (OPE) and Curcuma xanthorrhiza essential oil (CXEO) under hot conditions (34 °C with 50% relative humidity for 5 h daily starting from day 28 until day 38 of age) on blood antioxidant enzyme activities, biochemical parameters and antibody titres of broiler chickens were investigated. All extracts are rich in phenolic compounds and highly available. Compared to control, supplementation with OPE at 400 mg/kg and CXEO significantly increased erythrocyte glutathione peroxidase and superoxide dismutase activity, plasma growth hormone concentrations and serum phosphorus, total protein and chloride concentrations and decreased serum low‐density lipoprotein and cholesterol concentrations in chickens at 38 days of age. Regarding antibody titres, CXEO supplementation at 400 mg/kg caused a significant increase in bronchitis antibody titres. Supplementation with LPE and OPE gave more inconsistent results. Most interesting, 400 mg/kg LPE significantly increased 3,5,3′‐triiodothyronine and GH concentration as compared to the control. In conclusion, the herbal extracts tested in this study, in particular CXEO at 400 mg/kg, may relieve some of the changes in blood composition induced by increased ambient temperatures.
Risk factors for postoperative complications following bilateral closed anal sacculectomy in the dog
Authors: Charlesworth T. M. 
Published: April 2014

OBJECTIVESTo report the complication rate for bilateral closed anal sacculectomy in the dog and to evaluate potential risk factors for the development of postoperative complications. To identify breed groups at risk of requiring anal sacculectomy.METHODSA retrospective review of medical records of dogs undergoing bilateral closed anal sacculectomy between 2003 and 2013.RESULTSSixty‐two dogs were included in the study of which 32·3% developed mild and self‐limiting complications including 14·5% dogs that experienced postoperative defaecatory complications. No dog developed permanent faecal incontinence. Dogs less than 15 kg bodyweight were more likely to develop postoperative complications. Dogs that used gel to distend the anal sac were more likely to have postoperative complications than those that did not. Previous abscess formation, recurrent disease and pretreatment with antibiotics had no significant effect on postoperative complication rates. Cavalier King Charles spaniels and Labrador‐type dogs were over‐represented within this study population.CLINICAL SIGNIFICANCEAnal sacculectomy is a safe procedure with a relatively high rate of short‐term but self‐limiting, minor, postoperative complications. Smaller (<15 kg) dogs are more likely to experience postoperative complications but the risk of permanent faecal incontinence is low.
Hybridization between Crassostrea hongkongensis and Crassostrea ariakensis at Different Salinities
Authors: Huo Zhongming , Wang Zhaoping , Yan Xiwu , Yu Ruihai 
Published: April 2014

AbstractTo evaluate the survival and growth performance of hybrid larvae and juveniles, we conducted hybridization experiments between Crassostrea hongkongensis and Crassostrea ariakensis at three salinities (15, 23, and 30 ppt). Hybrid fertilization occurred in one direction (C. hongkongensis ♀ and C. ariakensis ♂), and the fertilization rates did not differ significantly among the three trial salinities. Molecular genetics analysis revealed that hybrid progenies were true hybrids. Hybrid juveniles survived better than C. hongkongensis juveniles at a salinity of 30 ppt. Hybrid larvae and juveniles showed intermediate growth between C. hongkongensis and C. ariakensis progenies. The growth of hybrid juveniles was significantly greater than that of C. hongkongensis juveniles at a salinity of 30 ppt. Overall, C. hongkongensis has a high economic value but favorable hatchery and farm of this species is restricted to lower salinity sites. Because the hybrids were shown to have greater growth and survival characteristics at high salinity, hybrids may be a more desirable candidate to be cultured in those areas of China with higher salinities, such as the Bohai Sea of China where the salinity is usually 30 ppt.
The Physical Condition and Welfare of Five Species of Wild‐caught Wrasse Stocked under Aquaculture Conditions and when Stocked in Atlantic Salmon, Salmo salar, Production Cages
Authors: Treasurer Jim , Feledi Tibor 
Published: April 2014

AbstractSeveral indices were examined to assess the physical condition of wrasse stocked on Atlantic salmon, Salmo salar, farms as cleaner fish, and included examination of eye condition, snout erosion, skin hemorrhaging, and erosion and splitting of dorsal, pectoral, anal and caudal fins. Baseline values were determined for five wrasse species: goldsinny, Ctenolabrus rupestris; rock cook, Centrolabrus exoletus; corkwing, Crenilabrus melops; cuckoo, Labrus mixtus; and ballan, Labrus bergylta, held in a farm environment for 3 mo prior to transfer to salmon farms. The caudal fin was most affected by injury. The fin erosion index (FEI) was low in all species and below 0.6. The fin splitting index (FSI) was the most prominent index and was significantly higher in the caudal fin (FSI > 2) compared with other fins (FSI < 0.5), and also significantly higher in corkwing and rock cook compared with the other wrasse species. The FEI and FSI were also calculated for a group of ballan wrasse before stocking on a seawater farm, during the first winter and upon harvesting. There were no significant differences in the scores of fin erosion and fin splitting in any of the samples, although the indices were marginally poorer in winter.
Effects of Various Levels of Silica Ash in the Diet of Juvenile Red Drum, Sciaenops ocellatus
Authors: Mendoza‐Rodriguez Maria G. , Gatlin Delbert M. 
Published: April 2014

AbstractThe demand for alternative feedstuffs to fish meal is anticipated to continue increasing due to fish meal's limited supply and escalating price. One group of alternative feedstuffs includes lipid‐extracted algae (LEA) by‐products from algae production for biofuels. Most LEA by‐products are known to contain relatively high levels of ash ranging from 20 to 30% of dry weight. Thus, inclusion of LEA by‐products in aquafeeds may contribute a substantial amount of ash, which potentially could have negative effects on utilization of other nutrients. To study the ash component of LEA by‐products, diatomaceous earth (DE) was used as a homogeneous source of silica ash. Therefore, two feeding trials were conducted with red drum, Sciaenops ocellatus, in a closed, recirculating system to evaluate the effects of graded levels of dietary silica ash. In Experiment 1, semi‐purified diets were formulated to contain 35% crude protein, with DE included at 0, 5, 10, 20, or 30% of dry weight in place of cellulose to provide diets with analyzed ash levels of 8.6, 12.4, 16.7, 25.5, and 33.8% of dry weight in a regression design. Similar diets were fed in Experiment 2 but DE and cellulose were restricted to no more than 20% of diet. Each diet was fed to triplicate groups of juvenile fish (initial average weight of 1.4 ± 0.2 and 2.3 ± 0.1 g) for 8 wk. In both experiments it was apparent that red drum did not respond negatively to even the highest dietary ash levels based on weight gain, feed efficiency, survival, or body composition. No apparent histological changes in the gastrointestinal tract of fish fed the graded levels of ash were observed. Therefore, inclusion of algae by‐products in diets of red drum will not be limited due to their contribution of ash.
Replacement of Fish Meal with Plant Feedstuffs in the Diet of Red Drum, Sciaenops ocellatus: Effects on Production Characteristics and Tolerance to Aquaculture‐Related Stressors
Authors: Moxley Joseph D. , Rossi Waldemar , Buentello Alejandro , Pohlenz Camilo , Gatlin Delbert M. , Tomasso Joseph R. 
Published: April 2014

AbstractThe continued expansion of intensive aquaculture activities requires that substitutes for fish meal‐based protein be identified. In this study, we evaluated partial (50 and 75%) replacement of fish meal in red drum, Sciaenops ocellatus, diets with soy protein concentrate (S) and barley protein concentrate (B). Growth, feed efficiency, survival, tolerance to low temperature, and tolerance to handling in warm, hypersaline water were evaluated. Only the diet with a 50% replacement of fish meal with S yielded results comparable to fish fed a nonsubstituted fish meal diet. However, the low‐temperature studies were complicated by differences in mean fish weight among the groups. The results of this study indicate S may be partially substituted for fish meal in red drum diets.
Shear bond strength of orthodontic attachments bonded to impacted teeth under in vivo and in vitro conditions
Authors: Arici N. , Bulut E. 
Published: April 2014

Structured AbstractObjectivesTo evaluate and compare the shear bond strength (SBS) of stainless steel and gold‐plated attachments to impacted lower third molars in vivo and in vitro with a light‐cured orthodontic resin.Setting and Sample PopulationSixteen patients with bilaterally full soft tissue impaction of lower third molars were recruited on a voluntary basis from an oral and maxillofacial surgery department.Materials and MethodsA split‐arch technique was used. Following surgical exposure of the crown, the tooth was luxated but not extracted. Then, two attachments (one stainless steel button and one gold‐plated eyelet) were bonded to the labial enamel surface of the loosened tooth. Five minutes later, the luxated tooth was removed from its socket. In each patient, the impacted tooth on the other side was extracted, and attachments were bonded in vitro. The SBSs of the attachments were evaluated. For comparison, analysis of variance and multiple range tests were used (α = 0.05).ResultsStatistically significant differences were evident in attachment adhesion to the impacted tooth surfaces among the four groups (p < 0.001). Superior SBS values were obtained for stainless steel button groups bonded in vitro. The mean bond strengths of the groups bonded in vitro were better than those of the same groups bonded in vivo.ConclusionsAlthough the in vitro‐bonded groups showed higher SBS values, adequate bond strength is possible with stainless steel buttons bonded in vivo.