bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Controlled Trial of a Telephone-Based Peer-Support Program for Women Carrying aBRCA1orBRCA2Mutation: Impact on Psychological Distress
Authors: White Victoria M. , Young Mary-Anne , Farrelly Ashley , Meiser Bettina , Jefford Michael , Williamson Elizabeth , Ieropoli Sandra , Duffy Jessica , Winship Ingrid 
Published: November 2014

PurposeTo assess the effectiveness of a telephone-based peer-delivered intervention in reducing distress among women with a BRCA1 or BRCA2 gene mutation. The intervention involved trained peer volunteers contacting women multiple times over a 4-month period to provide informational, emotional, and practical support.MethodsThree hundred thirty-seven participants completed the baseline questionnaire, and those reporting interest in talking to other mutation carriers were randomly assigned to either the usual care group (UCG; n = 102) or the intervention group (IG; n = 105). Participants and researchers were not blinded to group allocation. Two follow-up questionnaires were completed, one at the end of the intervention (4 months after random assignment, time 2) and one 2 months later (time 3). Outcomes included breast cancer distress (primary outcome), unmet information needs, cognitive appraisals about mutation testing, and feelings of isolation.ResultsThere was a greater decrease in breast cancer distress scores in the IG than UCG at time 2 (mean difference, −5.96; 95% CI, −9.80 to −2.12; P = .002) and time 3 (mean difference, −3.94; 95% CI, −7.70 to −0.17; P = .04). There was a greater reduction in unmet information needs in the IG than UCG (P < .01), with unmet needs being lower in the IG than UCG at time 2. There was a greater reduction in Cognitive Appraisals About Genetic Testing stress subscale scores in the IG than UCG (P = .02), with significantly lower scores among the IG than UCG at time 2 (P < .01).ConclusionThe intervention is effective in reducing distress and unmet information needs for this group of women. Identifying strategies for prolonging intervention effects is warranted.
Optimization of Rituximab for the Treatment of Diffuse Large B-Cell Lymphoma (II): Extended Rituximab Exposure Time in the SMARTE-R-CHOP-14 Trial of the German High-Grade Non-Hodgkin Lymphoma Study Group
Authors: Pfreundschuh Michael , Poeschel Viola , Zeynalova Samira , Hänel Mathias , Held Gerhard , Schmitz Norbert , Viardot Andreas , Dreyling Martin H. , Hallek Michael , Mueller Carsten , Wiesen Martin H.J. , Witzens-Harig Mathias , Truemper Lorenz , Keller Ulrich , Rixecker Tanja , Zwick Carsten , Murawski Niels 
Published: November 2014

Purpose To study pharmacokinetics, toxicity, and efficacy of prolonged rituximab exposure in elderly patients with diffuse large B-cell lymphoma (DLBCL). Patients and Methods In the SMARTE-R-CHOP-14 trial, rituximab 375 mg/m2 was administered, together with six cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone on a 14-day schedule (6×R-CHOP-14), on days −4, 0, 10, 29, 57, 99, 155, and 239. Pharmacokinetics and outcome were to be compared with those of patients who had received 6×R-CHOP-14 in combination with eight 2-week applications of rituximab in the RICOVER-60 (Rituximab With CHOP Over Age 60 Years) trial. Results The complete response (CR)/unconfirmed CR rate was 85% in 189 evaluable patients, 90% for 90 good-prognosis patients (International Prognostic Index [IPI], 1 or 2), and 81% for 99 poor-prognosis patients (IPI, 3 to 5); 3-year event-free survival (EFS) was 71%, 75%, and 67%, respectively; and 3-year overall survival (OS) was 84%, 88%, and 80%, respectively, with no differences between men and women. The preplanned historical comparison with 306 RICOVER-60 patients (good prognosis, n = 183; poor prognosis, n = 123) revealed no outcome differences for all and good-prognosis patients; however, the longer exposure time in SMARTE-R-CHOP-14 compared with RICOVER-60 was associated with better 3-year EFS (67% v 54%) and OS (80% v 67%) in poor-prognosis patients. Conclusion Extended rituximab exposure compared with eight 2-week applications in combination with 6×R-CHOP-14 significantly improved outcome of elderly poor-prognosis patients without increasing toxicity. To our knowledge, results obtained with the SMARTE-R-CHOP-14 rituximab schedule are the best reported for elderly patients with DLBCL to date. In the subgroup of poor-prognosis patients treated with extended rituximab exposure, the outcome seemed superior to that of a similar historical cohort of patients treated with 6×R-CHOP-14 plus 2-week rituximab, with similar toxicity. A randomized comparison of the two schedules is warranted.
Evaluation of the National Comprehensive Cancer Network and American Urological Association Renal Cell Carcinoma Surveillance Guidelines
Authors: Stewart Suzanne B. , Thompson R. Houston , Psutka Sarah P. , Cheville John C. , Lohse Christine M. , Boorjian Stephen A. , Leibovich Bradley C. 
Published: November 2014

Purpose The National Comprehensive Cancer Network (NCCN) and American Urological Association (AUA) provide guidelines for surveillance after surgery for renal cell carcinoma (RCC). Herein, we assess the ability of the guidelines to capture RCC recurrences and determine the duration of surveillance required to capture 90%, 95%, and 100% of recurrences. Patients and Methods We evaluated 3,651 patients who underwent surgery for M0 RCC between 1970 and 2008. Patients were stratified as AUA low risk (pT1Nx-0) after partial (LR-partial) or radical nephrectomy (LR-radical) or as moderate/high risk (M/HR; pT2-4Nx-0/pTanyN1). Guidelines were assessed by calculating the percentage of recurrences detected when following the 2013 and 2014 NCCN and AUA recommendations, and associated Medicare costs were compared. Results At a median follow-up of 9.0 years (interquartile range, 5.7 to 14.4 years), a total of 1,088 patients (29.8%) experienced a recurrence. Of these, 390 recurrences (35.9%) were detected using 2013 NCCN recommendations, 742 recurrences (68.2%) were detected using 2014 NCCN recommendations, and 728 recurrences (66.9%) were detected using AUA recommendations. All protocols missed the greatest amount of recurrences in the abdomen and among pT1Nx-0 patients. To capture 95% of recurrences, surveillance was required for 15 years for LR-partial, 21 years for LR-radical, and 14 years for M/HR patients. Medicare surveillance costs for one LR-partial patient were $1,228.79 using 2013 NCCN, $2,131.52 using 2014 NCCN, and $1,738.31 using AUA guidelines. However, if 95% of LR-partial recurrences were captured, costs would total $9,856.82. Conclusion If strictly followed, the 2014 NCCN and AUA guidelines will miss approximately one third of RCC recurrences. Improved surveillance algorithms, which balance patient benefits and health care costs, are needed.
Hyperglycemic Clamp and Oral Glucose Tolerance Test for 3-Year Prediction of Clinical Onset in Persistently Autoantibody-Positive Offspring and Siblings of Type 1 Diabetic Patients
Authors: Balti Eric V. , Vandemeulebroucke Evy , Weets Ilse , Van De Velde Ursule , Van Dalem Annelien , Demeester Simke , Verhaeghen Katrijn , Gillard Pieter , De Block Christophe , Ruige Johannes , Keymeulen Bart , Pipeleers Daniel G. , Decochez Katelijn , Gorus Frans K. ,   The Belgian Diabetes Registry
Published: November 2014

Abstract

Context and Objective:
In preparation of future prevention trials, we aimed to identify predictors of 3-year diabetes onset among oral glucose tolerance test (OGTT)- and hyperglycemic clamp-derived metabolic markers in persistently islet autoantibody positive (autoAb+) offspring and siblings of patients with type 1 diabetes (T1D).

Design:
The design is a registry-based study.

Setting:
Functional tests were performed in a hospital setting.

Participants:
Persistently autoAb+ first-degree relatives of patients with T1D (n = 81; age 5–39 years).

Main Outcome Measures:
We assessed 3-year predictive ability of OGTT- and clamp-derived markers using receiver operating characteristics (ROC) and Cox regression analysis. Area under the curve of clamp-derived first-phase C-peptide release (AUC5–10min; min 5–10) was determined in all relatives and second-phase release (AUC120–150min; min 120–150) in those aged 12–39 years (n = 62).

Results:
Overall, the predictive ability of AUC5–10min was better than that of peak C-peptide, the best predictor among OGTT-derived parameters (ROC-AUC [95%CI]: 0.89 [0.80–0.98] vs 0.81 [0.70–0.93]). Fasting blood glucose (FBG) and AUC5–10min provided the best combination of markers for prediction of diabetes within 3 years; (ROC-AUC [95%CI]: 0.92 [0.84–1.00]). In multivariate Cox regression analysis, AUC5–10min (P = .001) was the strongest independent predictor and interacted significantly with all tested OGTT-derived parameters. AUC5–10min below percentile 10 of controls was associated with 50–70% progression to T1D regardless of age. Similar results were obtained for AUC120–150min.

Conclusions:
Clamp-derived first-phase C-peptide release can be used as an efficient and simple screening strategy in persistently autoAb+ offspring and siblings of T1D patients to predict impending diabetes.
The Opportunities of Project Activity in Specialized Education
Authors: Иоффе  , Ioffe A. 
Published: November 2014

The subject of project activity becomes very popular and actual after adoption of new educational standards in the Russian education system. At the
same time, disputes on terminology are proceeded, and there is no unity in understanding of essential elements of the project. Quite often projects
are understood as any creative work. The profile school pays special attention to the project conception. Therefore it is important to raise problematic
questions and try to answer them. This article is devoted to it.
How Should Cartels React to Entry Triggered by Demand Growth?
Authors: Correia-da-Silva João , Pinho Joana , Vasconcelos Hélder 
Published: November 2014

Abstract
We study the sustainability of collusion with optimal penal codes in markets where demand growth triggers the entry of a new firm. In contrast to grim trigger strategies, optimal penal codes make collusion easier to sustain before entry than after. This conclusion is robust to changes in the number of entrants and to the consideration of price-setting instead of quantity-setting. A comparison is given between different reactions of the incumbents to entry in terms of sustainability of collusion, incumbents’ profits, entrant’s profits, consumer surplus and social welfare. One of our findings is that the incumbent firms may prefer competition to collusion.
Comparing HbA1c, fasting and 2-h plasma glucose for screening for abnormal glucose regulation in patients undergoing coronary angiography
Authors: Wang Jun-Sing , Lee I-Te , Lee Wen-Jane , Lin Shih-Yi , Fu Chia-Po , Lee Wen-Lieng , Liang Kae-Woei , Sheu Wayne Huey-Herng 
Published: November 2014

AbstractWe aimed to investigate the prevalence of undiagnosed abnormal glucose regulation (AGR, including diabetes and prediabetes) in patients undergoing coronary angiography (CAG) by using both glycated hemoglobin (HbAEligible patients were adults without known diabetes who were admitted for CAG. Patients’ glucose regulation status was defined by conducting HbAA total of 689 subjects were included. According to OGTT, the prevalence rates of diabetes and prediabetes were 19.9% and 41.7%, respectively. The corresponding values were 28.0% and 60.4%, respectively, when HbAUsing HbA
Synthesis of bio-active titanium oxide coatings stimulated by electron-beam plasma
Authors: Vasilieva Tatiana , Sokolov Igor , Sigarev Andrey , Tun Win Aung 
Published: November 2014

Abstract
Advantages of the electron-beam plasma (EBP) for production of bioactive titanium oxide coatings were experimentally studied. The coatings were synthesized in EBP of oxygen on the surface of plane titanium substrates. A number of analytical techniques were used to characterize morphology, chemical composition, and structure of the synthesized titanium oxide. The analysis showed the titanium oxide (IV) in the rutile form to predominate in the coatings composition.

The samples with plasmachemically synthesized TiO2-coatings were more hydrophilic than untreated titanium. The effect was stable during two weeks and then the degradation of the wettability began. The EBP-stimulated TiO2 synthesis improved the hydroxyapatite formation on the surface of plane titanium substrates. The EBP-stimulated TiO2 synthesis is promising technique to produce bioactive coatings on the surface of titanium medical dental and bone implants.

The computer simulation of plasma-surface interaction was carried out to predict the plasma composition, to find the spatial distribution of the sample temperature, and to calculate the flows of the chemically active plasma particles bombarding the tube wall. The flows of atomic and singlet oxygen were found to be the most intensive and, therefore, these particles are likely to be responsible for the formation of the biocompatible TiO2-coaings.
Nonthermal plasma modification of polypropylene fibres for cementitious composites
Authors: Morávek Tomáš , Fialová Monika , Kopkáně Daniel , Ráheľ Jozef , Sťahel Pavel , Černák Mirko 
Published: November 2014

Abstract
The plasma treatment of polypropylene fibres used as concrete admixtures for improving its mechanical properties is the focus of this research paper. A plasma treatment was conducted in a low-temperature plasma environment at atmospheric pressure in a DCSBD (Diffuse Coplanar Surface Barrier Discharge). The degree of hydrophilicity caused by the plasma treatment was determined by measuring the rate of penetration of water into the porous media, commonly referred to as the Washburn method. The influence of the addition of PP (polypropylene) fibres to the concrete matrix was investigated using a three point bending test which determined the flexural strength of concrete samples. Our experiments demostrate that plasma improves both the wettability of PP fibres and its adhesion to the concrete matrix. The tests of flexural strength show, that even a short plasma treatment (5 s) can have a significant impact on the mechanical properties of fibre-reinforced concrete composite.
Degradation of AB25 dye in liquid medium by atmospheric pressure non-thermal plasma and plasma combination with photocatalyst TiO2
Authors: Ghodbane Houria , Hamdaoui Oualid , Vandamme Jeroen , Van Durme Jim , Vanraes Patrick , Leys Christophe , Nikiforov Anton Y. 
Published: November 2014

Abstract
In this work, degradation of the anthraquinonic dye Acid Blue 25 by non-thermal plasma at atmospheric pressure with and without photocatalyst is investigated. Titanium dioxide (TiO2) is used as a photocatalyst. The dye degradation by plasma in the presence of TiO2 is investigated as a function of TiO2 concentration, dye concentration and pH. The degradation rate is higher in acidic solutions with pH of 2 to 4.3, especially at pH 2, and decreases to 0.38 mg L-1 min-1 with the increase of pH from 2 to 5.65. A similar effect is observed in basic media, where a higher degradation rate is found at pH = 10.3. The degradation rate increases in the presence of TiO2 compared to the discharge without photocatalysis. The results show that the degradation of the dye increases in the presence of TiO2 until the catalyst load reaches
0.5 g L-1 after which the suppression of AB25 degradation is observed. The results indicate that the tested advanced oxidation processes are very effective for the degradation of AB25 in aqueous solutions.
“Bare” or “Gloved” Hands: A Study on the Production of Safe Food
Authors: Brizio Ana Paula Dutra Resem , Prentice Carlos 
Published: November 2014

Abstract
There is no documented evidence proving that the meat products produced by “gloved” hands are safer than those produced by “bare” hands. Thus, this paper proposes to conduct a microbiological investigation to assess cross-contamination between handlers and poultry products in three distinct processing situations: without the use of gloves (bare hands), with the use of reusable gloves and using disposable gloves. The microbiological results showed that the use of hands protected by disposable gloves was significantly better (p < 0.05) compared to the use of bare hands and hands containing reusable gloves. Thus, the adoption of disposable gloves combined with good manufacturing practices training seems to be the most reliable alternative to reduce handler–food contamination during the preparation of poultry products.
Metastable metal imidazolates: development of targeted syntheses by combining experimental and theoretical investigations of the formation mechanisms
Authors: Schröder Christian A. , Saha Sanjib , Huber Klaus , Leoni Stefano , Wiebcke Michael 
Published: November 2014

Abstract
In this report, we summarize our experimental and theoretical investigations in the zinc(II) imidazolate, [Zn(im)2], and zinc(II) 4,5-dichloroimidazolate, [Zn(dcim)2], systems that have been published previously. This comprises a study on the thermodynamic stabilities of the two densest phases with coi and zni framework structures in the [Zn(im)2] system including the discovery and characterization of a new [Zn(im)2·0.5py]-neb phase (py = pyridine), a study on the mechanism of formation of the [Zn(im)2]-zni phase as well as a study on the discovery and characterization of a new [Zn(dcim)2]-SOD phase. In addition, we present as yet unpublished work. This concerns the discovery and characterization of a new [Zn(im)2·0.5mor]-neb phase (mor = morpholine) and investigations of the mechanisms of crystallization of [Zn(im)2·0.5py]-neb and [Zn(im)2·0.5mor]-neb as well as an evalutation of time-resolved SAXS/WAXS data recorded in-situ during the formation of [Zn(im)2]-zni.
A Pécsi Egyetemtörténeti Gyűjtemény képadatbázisa (eKéPEK)
Authors: Dezső Krisztina , Schmelczer-Pohánka Éva 
Published: November 2014

A pécsi egyetemtörténeti relikviák gyűjtésének története nem új keletű a Pécsi Tudományegyetemen, 2010 nyarától pedig hivatalosan is az Egyetemi Könyvtár feladatköre. A könyvtár Történeti Gyűjtemények Osztályának részét képező Pécsi Egyetemtörténeti Gyűjteményben az alábbi gyűjteménytestek különíthetők el dokumentumtípusok szerint: a dokumentumgyűjtemény, a történeti tárgyak gyűjteménye és a fotógyűjtemény. Egyik legfontosabb feladatunknak tekintjük az állományok egyes darabjainak mind részletesebb feldolgozását, tárgyszavazását, azaz a visszakereshetőség szavatolását és a kutatásokra való alkalmassá tételét. Ekképpen online adatbázisokban, katalógusokban tárjuk fel ezek vonatkozó adatait. Jelen tanulmányunkban a fotógyűjtemény használatához elengedhetetlenül szükséges online adatbázis bemutatását tűztük ki célul.
Fotó: Pécsi Egyetemtörténeti Gyűjtemény
Medication Adherence Among Pediatric Patients With Sickle Cell Disease: A Systematic Review
Authors: Walsh Kathleen E. , Cutrona Sarah L. , Kavanagh Patricia L. , Crosby Lori E. , Malone Chris , Lobner Katie , Bundy David G. 
Published: November 2014

OBJECTIVES:Describe rates of adherence for sickle cell disease (SCD) medications, identify patient and medication characteristics associated with nonadherence, and determine the effect of nonadherence and moderate adherence (defined as taking 60%–80% of doses) on clinical outcomes.METHODS:In February 2012 we systematically searched 6 databases for peer-reviewed articles published after 1940. We identified articles evaluating medication adherence among patients &lt;25 years old with SCD. Two authors reviewed each article to determine whether it should be included. Two authors extracted data, including medication studied, adherence measures used, rates of adherence, and barriers to adherence.RESULTS:Of 24 articles in the final review, 23 focused on 1 medication type: antibiotic prophylaxis (13 articles), iron chelation (5 articles), or hydroxyurea (5 articles). Adherence rates ranged from 16% to 89%; most reported moderate adherence. Medication factors contributed to adherence. For example, prophylactic antibiotic adherence was better with intramuscular than oral administration. Barriers included fear of side effects, incorrect dosing, and forgetting. Nonadherence was associated with more vaso-occlusive crises and hospitalizations. The limited data available on moderate adherence to iron chelation and hydroxyurea indicates some clinical benefit.CONCLUSIONS:Moderate adherence is typical among pediatric patients with SCD. Multicomponent interventions are needed to optimally deliver life-changing medications to these children and should include routine monitoring of adherence, support to prevent mistakes, and education to improve understanding of medication risks and benefits.
Sex-Related Online Behaviors and Adolescents’ Body and Sexual Self-Perceptions
Authors: Doornwaard Suzan M. , Bickham David S. , Rich Michael , Vanwesenbeeck Ine , van den Eijnden Regina J.J.M. , ter Bogt Tom F.M. 
Published: November 2014

BACKGROUND AND OBJECTIVE:
This study investigated: (1) the prevalence and development of 2 receptive (sexually explicit Internet material [SEIM] use and sexual information seeking) and 2 interactive (cybersex and general social networking site [SNS] use) online behaviors in adolescence; (2) whether development of these behaviors predict adolescents’ body and sexual self-perceptions; and (3) whether parental strategies regarding adolescents’ Internet use reduce engagement in sex-related online behaviors.

METHODS:
Four-wave longitudinal data among 1132 seventh- to 10th-grade Dutch adolescents (mean age at wave 1: 13.95 years; 52.7% boys) were collected. Developmental trajectories of sex-related online behaviors were estimated by using latent growth curve modeling. Self-perception outcomes at wave 4 and parental strategies predicting online behaviors were investigated by adding regression paths to growth models.

RESULTS:
Boys occasionally and increasingly used SEIM. Patterns for girls’ SEIM use and boys’ and girls’ sexual information seeking and cybersex were consistently low. SNS use, however, was a common, daily activity for both. Higher initial levels and/or faster increases in sex-related online behaviors generally predicted less physical self-esteem (girls’ SNS use only), more body surveillance, and less satisfaction with sexual experience. Private Internet access and less parental rule setting regarding Internet use predicted greater engagement in sex-related online behaviors.

CONCLUSIONS:
Although most sex-related online behaviors are not widespread among youth, adolescents who engage in such behaviors are at increased risk for developing negative body and sexual self-perceptions. Particular attention should be paid to adolescents’ SNS use because this behavior is most popular and may, through its interactive characteristics, elicit more critical self-evaluations. Prevention efforts should focus on parents’ role in reducing risky sex-related online behaviors.