bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond large complex structure: quantized periods and boundary data for one-modulus singularities
Authors: Bastian Brice , van de Heisteeg Damian , Schlechter Lorenz 
Published: July 2024

Abstract
We study periods in an integral basis near all possible singularities in one-dimensional complex structure moduli spaces of Calabi-Yau threefolds. Near large complex structure points these asymptotic periods are well understood in terms of the topological data of the mirror Calabi-Yau manifold. The aim of this work is to characterize the period data near other boundaries in moduli space such as conifold and K-points. Using results from Hodge theory, we provide the general form of these periods in a quantized three-cycle basis. Based on these periods we compute the prepotential and related physical couplings of the underlying supergravity theory. Moreover, we elucidate the meaning of the model-dependent coefficients that appear in these expressions: these can be identified with certain topological and arithmetic numbers associated to the singular geometry at the moduli space boundary. We illustrate our findings by studying a wide set of examples.
Probing heavy neutrino magnetic moments at the LHC using long-lived particle searches
Authors: Beltrán Rebeca , Bolton Patrick D. , Deppisch Frank F. , Hati Chandan , Hirsch Martin 
Published: July 2024

Abstract
We explore long-lived particle (LLP) searches using non-pointing photons at the LHC as a probe for sterile-to-sterile and active-to-sterile transition magnetic dipole moments of sterile neutrinos. We consider heavy sterile neutrinos with masses ranging from a few GeV to several hundreds of GeV. We discuss transition magnetic dipole moments using the Standard Model effective field theory and low-energy effective field theory extended by sterile neutrinos (NRSMEFT and NRLEFT) and also provide a simplified UV-complete model example. LLP searches at the LHC using non-pointing photons will probe sterile-to-sterile dipole moments two orders of magnitude below the current best constraints from LEP, while an unprecedented sensitivity to sterile neutrino mass of about 700 GeV is expected for active-to-sterile dipole moments. For the UV model example with one-loop transition magnetic moments, the searches for charged lepton flavour violating processes in synergy with LLP searches at the LHC can probe new physics at several TeV mass scales and provide valuable insights into the lepton flavour structure of new physics couplings.
The cubic-quintic nonlinear Schrödinger equation with inverse-square potential
Authors: Ardila Alex H. , Murphy Jason 
Published: July 2024

AbstractWe consider the nonlinear Schrödinger equation in three space dimensions with a focusing cubic nonlinearity and defocusing quintic nonlinearity and in the presence of an external inverse-square potential. We establish scattering in the region of the mass-energy plane where the virial functional is guaranteed to be positive. Our result parallels the scattering result of [11] in the setting of the standard cubic-quintic NLS.
Absetzen anfallssuppressiver Medikamente bei Patient*innen mit Epilepsie
Authors: Ilyas-Feldmann Maria , Graf Luise , Hüsing Thea , Dörrfuß Jakob , Holtkamp Martin 
Published: July 2024

Zusammenfassung
Hintergrund
Etwa zwei Drittel der Patient*innen mit Epilepsie werden unter der Einnahme anfallssuppressiver Medikamente (ASM) anfallsfrei. Eine zentrale Frage ist, ob und wann ASM wieder abgesetzt werden können.

Ziel der Arbeit
Überblick zum aktuellen Kenntnisstand über Risiken und Nutzen des Absetzens von ASM.

Methoden
Zusammenfassung der aktuellen Literatur, Diskussion der Datenlage und Ableitung von Therapieempfehlungen.

Ergebnisse
Das Risiko für Anfallsrezidive nach dem Absetzen von ASM ist mit 40–50 % ungefähr doppelt so hoch wie unter der weiteren Einnahme von ASM. Leitlinien empfehlen, das Absetzen von ASM frühestens nach 2‑jähriger Anfallsfreiheit zu erwägen. Prädiktive Faktoren für ein Anfallsrezidiv nach dem Absetzen von ASM umfassen eine längere Dauer der Epilepsie und eine höhere Anzahl epileptischer Anfälle bis zur klinischen Remission, ein kürzeres anfallsfreies Intervall bis zum Absetzen, ein höheres Alter bei Erstmanifestation, eine Entwicklungsverzögerung bzw. ein IQ < 70, Fieberkrämpfe in der Kindheit, das Nichtvorliegen eines selbstlimitierenden Epilepsiesyndroms und der Nachweis epilepsietypischer Muster im EEG. Mithilfe einer webbasierten Prognosesoftware kann das individuelle Risiko eines Anfallsrezidivs nach dem Absetzen von ASM abgeschätzt werden.

Schlussfolgerungen
Ein Absetzen von ASM sollte frühestens nach 2 Jahren Anfallsfreiheit in einer gemeinsamen Entscheidungsfindung von Ärzt*innen und Patient*innen unter Abwägung von Nutzen und Risiken besprochen werden. Das Risiko eines erneuten Anfalls wird durch eine Reihe klinischer Variablen beeinflusst. Psychosoziale Aspekte wie Fahreignung und die berufliche Situation müssen ebenso berücksichtigt werden wie individuelle Ängste und Sorgen der Patient*innen vor einem Anfallsrezidiv oder der dauerhaften Einnahme von ASM.
Simulation-based data reduction and data processing for sheet metal forming in the hybrid twin framework
Authors: Maier Lorenz , Ünver Bogac , Volk Wolfram , Hartmann Christoph 
Published: July 2024

AbstractIn sheet metal forming, the interaction between virtual models and the real world remains challenging. Process simulations can exhibit significant errors, and reliable measurements are often scarce during early production stages. This study presents a hybrid twin framework that systematically unifies computer-aided design, simulation, and measurement data in an adaptive manner. Central to this framework is a reverse engineering algorithm that reconstructs and transforms the geometry of deep-drawn components from optical scan data into B-spline surfaces. The algorithm demonstrated high precision, indicating its suitability for process control and geometric analysis. The hybrid twin framework integrates virtual data from simulations and real-world data, as evidenced by a sensor concept for inline surface measurement. The framework ensures robust and redundant measurement concepts by estimating complete geometries from a few systematically preselected measuring points. This adaptive approach permits continuous updates and extensions to the database, accommodating both sparse inline signals and offline inspection data. This framework provides a conceptual model for integrating direct feedback interactions between virtual and physical environments, thereby enhancing the precision of analytical and predictive models in sheet metal forming processes.
Reduction in motor error by presenting subthreshold somatosensory information during visuomotor tracking tasks
Authors: Wasaka Toshiaki , Kano Shota , Morita Yoshifumi 
Published: July 2024

AbstractWeak sensory noise acts on the nervous system and promotes sensory and motor functions. This phenomenon is called stochastic resonance and is expected to be applied for improving biological functions. This study investigated the effect of electrical stimulation on grip force adjustment ability. The coefficient of variation and absolute motor error in grip force was measured during a visuomotor tracking task under different intensities of somatosensory noise. Depending on the style of force exertion, the grip movement used in the visuomotor tracking task consisted of force generation (FG), force relaxation (FR), and constant contraction (Constant) phases. The subthreshold condition resulted in significantly lower coefficient of variation in the Constant phase and motor errors in the FG and Constant phases than the no-noise condition. However, the differences among the other conditions were insignificant. Additionally, we examined the correlation between the motor error in the condition without electrical stimulation and the change in motor error induced by subthreshold electrical stimulation. Significant negative correlations were observed in all FG, FR, and Constant phases. These results indicated that somatosensory noise had a strong effect on subjects with large motor errors and enhanced the grip force adjustment ability. By contrast, subjects with small motor errors had weak improvement in motor control. Although the effect of subthreshold noise varies depending on the individual differences, stochastic resonance is effective in improving motor control ability.
Effect of L-HSL on biofilm and motility of Pseudomonas aeruginosa and its mechanism
Authors: Tang Deping , Lin Yanyan , Yao Huihui , Liu Yali , Xi Yanpeng , Li Mengjiao , Mao Aihong 
Published: July 2024

Abstract
Pseudomonas aeruginosa (P. aeruginosa) biofilm formation is a crucial cause of enhanced antibiotic resistance. Quorum sensing (QS) is involved in regulating biofilm formation; QS inhibitors block the QS signaling pathway as a new strategy to address bacterial resistance. This study investigated the potential and mechanism of L-HSL (N-(3-cyclic butyrolactone)-4-trifluorophenylacetamide) as a QS inhibitor for P. aeruginosa. The results showed that L-HSL effectively inhibited the biofilm formation and dispersed the pre-formed biofilm of P. aeruginosa. The production of extracellular polysaccharides and the motility ability of P. aeruginosa were suppressed by L-HSL. C. elegans infection experiment showed that L-HSL was non-toxic and provided protection to C. elegans against P. aeruginosa infection. Transcriptomic analysis revealed that L-HSL downregulated genes related to QS pathways and biofilm formation. L-HSL exhibits a promising potential as a therapeutic drug for P. aeruginosa infection.

Key points
• Chemical synthesis of N-(3-cyclic butyrolactone)-4-trifluorophenylacetamide, named L-HSL.
• L-HSL does not generate survival pressure on the growth of P. aeruginosa and can inhibit the QS system.
• KEGG enrichment analysis found that after L-HSL treatment, QS-related genes were downregulated.
An in-vivo study of the safety of copper-containing intrauterine devices in 3.0 Tesla magnetic resonance imaging
Authors: Moy Jeffrey , Landon Matthew , Vigilante John , Lehmann Benjamin , DeChambeau Amber , Rohlfing Frederick , Marks Robert 
Published: July 2024

Abstract
Purpose
The aim of this study is to prospectively evaluate whether women with copper-containing intrauterine devices (Cu-IUD), currently listed as MR conditional, can safely undergo 3.0 Tesla (3 T) magnetic resonance imaging (MRI).

Methods
73 women, age 18–54 years old, with a Cu-IUD who were undergoing MRI for any reason were included consecutively. Pre- and post-MRI standard pelvic ultrasound examinations were completed to determine the appropriate pre- and post-MRI positioning of the Cu-IUD. Displaced IUDs were defined by IUD crossbars not in the fundal portion of the endometrial cavity, a visualized tip in the mid or lower uterus, any part of the device located in the cervical canal or outside of the endometrial canal, a fractured device, or a non-visualized IUD. Additionally, a questionnaire was completed by participants to determine the level of pre- and post-MRI pelvic pain.

Results
There were zero observed displaced Cu-IUDs on post-MRI pelvic ultrasounds (p = 0/70, 95% CI 0, .043). Three participants were dropped from the study due to malpositioned IUDs on pre-MRI pelvic ultrasound. Six patients reported new or worsening pelvic pain/discomfort during or after their MRI examination.

Conclusion
Our results suggest that performing 3 T MRI using a low SAR setting does not cause displacement of Cu-IUDs, with zero out of 70 patients demonstrating IUD displacement.

Graphical Abstract
The emerging paradigm in pediatric rheumatology: harnessing the power of artificial intelligence
Authors: Koker Oya , Sahin Sezgin , Yildiz Mehmet , Adrovic Amra , Kasapcopur Ozgur 
Published: July 2024

AbstractArtificial intelligence algorithms, with roots extending into the past but experiencing a resurgence and evolution in recent years due to their superiority over traditional methods and contributions to human capabilities, have begun to make their presence felt in the field of pediatric rheumatology. In the ever-evolving realm of pediatric rheumatology, there have been incremental advancements supported by artificial intelligence in understanding and stratifying diseases, developing biomarkers, refining visual analyses, and facilitating individualized treatment approaches. However, like in many other domains, these strides have yet to gain clinical applicability and validation, and ethical issues remain unresolved. Furthermore, mastering different and novel terminologies appears challenging for clinicians. This review aims to provide a comprehensive overview of the current literature, categorizing algorithms and their applications, thus offering a fresh perspective on the nascent relationship between pediatric rheumatology and artificial intelligence, highlighting both its advancements and constraints.
Automatized detection of uniparental disomies in a large cohort
Authors: Moch Johanna , Radtke Maximilian , Liehr Thomas , Eggermann Thomas , Gilissen Christian , Pfundt Rolph , Astuti Galuh , Hentschel Julia , Schumann Isabell 
Published: July 2024

AbstractUniparental disomy (UPD) is the inheritance of both homologues of a chromosome from only one parent. The detection of UPDs in sequencing data is not well established and a common gap in genetic diagnostics. We applied our in-house UPD detection pipeline to evaluate a cohort of 9212 samples, including multigene panels as well as exome sequencing data in a single, duo or trio constellation. We used the results to inform the design of our publicly available web app altAFplotter. UPDs categorized as heterodisomy, whole chromosome or segmental isodisomy were identified and validated with microsatellites, multiplex ligation-dependent probe amplification as well as Sanger sequencing. We detected 14 previously undiagnosed UPDs including nine isodisomies, four segmental isodisomies as well as one heterodisomy on chromosome 22. We characterized eight findings as potentially causative through homozygous pathogenic variants or imprinting disorders. Overall, our study demonstrates the utility of our UPD detection pipeline with our web app, altAFplotter, to reliably identify UPDs. This not only increases the diagnostic yield of cases with growth and metabolic disturbances, as well as developmental delay, but also enhances the understanding of UPDs that may be relevant for recurrence risks and genetic counseling.
Effect of competition intensity and neighbor identity on architectural traits of Fagus sylvatica
Authors: Penanhoat Alice , Guerrero Ramirez Nathaly , Aubry-Kientz Mélaine , Diekmann Lucas , Paligi Sharath , Audisio Michela , Mrak Klara , Seidel Dominik 
Published: July 2024

Abstract
Key message
Differences in architectural traits of European beech saplings submitted to different levels of competition intensity and neighborhood diversity show a shift toward lateral growth exploration for overtopped trees but less expressed apical control is maintained for beech grown with conifers.

Abstract
Crown plasticity is a fundamental process to optimize the acquisition of light in forests, where it is often the limiting factor for growth. The processes leading to crown dynamics in response to biotic interaction are controlled by the competitive status of a tree, as well as the species diversity of the neighborhood. Yet, the ontogenic diversity of the different branches leading to crown structure makes it difficult to model crown plasticity. In this study, we used single-image photogrammetry and a semi-automatic topology reconstruction software to map the architecture of 3-year-old European beech trees (Fagus sylvatica L.) grown in pure pots or mixed with Douglas fir (Pseudotsuga menziesii (Mirbel) Franco) or Norway spruce (Piceaabies L. H.Karst). Further, we investigated the effect of competition intensity (estimated with height rank) and neighbourhood diversity on architectural traits. To do so, we quantified the mean volume, slenderness, number of branches, branching rate, internode length, and diameter ratio for each stem and branch, up to the order three. Overtopped trees developed fewer branches and biomass but allocated more biomass to branches of a higher order than to the stem. The increase in the ramification of the stem and the diameter ratio of the first-order branches for overtopped trees indicate a shift in the growth strategy and a decrease in apical control. As competition intensity and neighbour identity have opposite effects on stem traits, it seems that the positive effect of plant diversity on growth can be attributed to the intrinsic effects of species identity rather than to competition release.
Functional frontal lobectomy in the surgical treatment of pharmacoresistant frontal lobe epilepsy: how I do it
Authors: Battista Francesca , Esposito Alice , Muscas Giovanni , Della Puppa Alessandro 
Published: July 2024

Abstract

Background
Frontal lobe epilepsy is pharmacoresistant in 30% of cases, constituting 10–20% of epilepsy surgeries. For cases of no lesional epilepsy (negative MRI), frontal lobectomy is a crucial treatment, historically involving Frontal Anatomical Lobectomy (AFL) with a 33.3% complication risk and 55.7% seizure control.

Methods
We describe Frontal Functional Lobectomy (FFL), in which the boundaries are defined on the patient's functional cortico-subcortical areas, recognized with advanced intraoperative technologies such as tractography and navigated transcranial magnetic stimulation (nTMS).

Conclusions
The FFL allows for a broader resection with a lower rate of postoperative complications than the AFL.
Is SWEEPS better than PUI in reducing intracanal bacteria and inflammation in cases of apical periodontitis?
Authors: Hepsenoglu Yelda Erdem , Ersahan Seyda , Erkan Erhan , Gundogar Mustafa , Ozcelik Fatih 
Published: July 2024

Abstract
To evaluate the efficacy of SWEEPS mode of the Er: YAG laser(SL) and passive ultrasonic irrigation(PUI) in the eradication of microorganisms and in the inflammation detection by IL-1β. Thirty patients with chronic apical periodontitis(AP) were allocated into two groups: Group SL–SWEEPS laser activated irrigation(n = 15) and Group PUI–passive ultrasonic irrigation(n = 15). Bacteriological samples were taken before(S1) and after chemomechanical preparation(S2), and then after final irrigation activation(S3). The levels of total bacteria and Streptococci were measured by means of PCR. Blood samples were collected before and 3rd day after treatment. Enzyme-linked immunosorbent assay was used to measure the levels of IL-1β. The bacterial reduction showed no differences between groups after chemo-mechanical treatment and after irrigant activation(p = 0.590). Post-treatment IL-1β levels were lower than pretreatment levels in both groups(p < 0.001). SL or PUI application in addition to chemomechanical preparation has similar effects on total bacterial level and inflammation detected by IL-1β in patients with AP.
Economies of scope in the Norwegian public hospital sector
Authors: Lindaas Nils Arne , Anthun Kjartan Sarheim , Kittelsen Sverre A. C. , Magnussen Jon 
Published: July 2024

AbstractThis study investigates the potential economies of scope in the Norwegian public hospital sector after a major structural and organizational reform. Economies of scope refers to potential cost savings occurring from the scope of production rather than the scale. We use a data driven approach to distinguish between relatively specialized and differentiated hospitals. Using registry data spanning the period 2013–2019, we use non-parametric data envelopment analysis with bootstrapping procedures to investigate the potential presence of economies of scope. This is done separately for three different dimensions of which hospital production can be either specialized or differentiated. The findings suggest that economies of scope are present in the Norwegian hospital sector, meaning that there are cost savings related to the optimal differentiation of the activity. It is difficult to conclude on how these findings relate to the reform.
Optical Marker-Based Motion Capture of the Human Spine: A Scoping Review of Study Design and Outcomes
Authors: Romero-Flores Claudia F. , Bustamante-Bello Rogelio , Moya Bencomo Marcos , Martinez-Ríos Erick Axel , Montesinos Luis 
Published: July 2024

AbstractBiomechanical analysis of the human spine is crucial to understanding injury patterns. Motion capture technology has gained attention due to its non-invasive nature. Nevertheless, traditional motion capture studies consider the spine a single rigid segment, although its alignment changes during movement. Moreover, guidelines that indicate where markers should be placed for a specific exercise do not exist. This study aims to review the methods used to assess spine biomechanics using motion capture systems to determine the marker sets used, the protocols used, the resulting parameters, the analysed activities, and the characteristics of the studied populations. PRISMA guidelines were used to perform a Scoping Review using SCOPUS and Web of Science databases. Fifty-six journal and conference articles from 1997 to 2023 were considered for the analysis. This review showed that Plug-in-Gait is the most used marker set. The lumbar spine is the segment that generates the most interest because of its high mobility and function as a weight supporter. Furthermore, angular position and velocity are the most common outcomes when studying the spine. Walking, standing, and range of movement were the most studied activities compared to sports and work-related activities. Male and female participants were recruited similarly across all included articles. This review presents the motion capture techniques and measurement outcomes of biomechanical studies of the human spine, to help standardize the field. This work also discusses trends in marker sets, study outcomes, studied segments and segmentation approaches.
Graphical Abstract
Historical Portuguese corpora: a survey
Authors: Osório Tomás Freitas , Lopes Cardoso Henrique 
Published: July 2024

AbstractThis survey aims to thoroughly examine and evaluate the current landscape of electronic corpora in historical Portuguese. This is achieved through a comprehensive analysis of existing resources. The article makes two main contributions. The first is an exhaustive cataloguing of existing Portuguese historical corpora, where each corpus is meticulously detailed regarding linguistic periods, geographic origins, and thematic contents. The second contribution focuses on the digital accessibility of these corpora for researchers. These contributions are crucial in enhancing and progressing the study of historical corpora in the Portuguese language, laying a critical groundwork for future linguistic research in this field. Our survey identified 20 freely accessible corpora, comprising approximately 63.9 million tokens, and two private corpora, totalling 59.9 million tokens.