bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Low-dose Oral Prednisolone on Symptoms and Systemic Inflammation in Older Adults with Moderate to Severe Knee Osteoarthritis: A Randomized Placebo-controlled Trial
Authors: Abou-Raya Anna , Abou-Raya Suzan , Khadrawi Tarek , Helmii Madihah 
Published: December 2013

Objective.To investigate the efficacy of 6 weeks of daily low-dose oral prednisolone in improving pain, mobility, and systemic low-grade inflammation in the short term and whether the effect would be sustained at 12 weeks in older adults with moderate to severe knee osteoarthritis (OA).Methods.A total of 125 patients with primary knee OA were randomized 1:1; 63 received 7.5 mg/day of prednisolone and 62 received placebo for 6 weeks. Outcome measures included pain reduction and improvement in function scores and systemic inflammation markers. Pain was assessed using the visual analog pain scale (0–100 mm). Secondary outcome measures included the Western Ontario and McMaster Universities Osteoarthritis Index scores, patient global assessment (PGA) of the severity of knee OA, and 6-min walk distance (6MWD). Serum levels of interleukin 1 (IL-1), IL-6, tumor necrosis factor (TNF)-α, and high-sensitivity C-reactive protein (hsCRP) were measured.Results.There was a clinically relevant reduction in the intervention group compared to the placebo group for knee pain, physical function, PGA, and 6MWD at 6 weeks. The mean difference between treatment arms (95% CI) was 10.9 (4.8–18.0), p < 0.001; 9.5 (3.7–15.4), p < 0.05; 15.7 (5.3–26.1), p < 0.001; and 86.9 (29.8–144.1), p < 0.05, respectively. Further, there was a clinically relevant reduction in the serum levels of IL-1, IL-6, TNF-α, and hsCRP at 6 weeks in the intervention group when compared to the placebo group. These differences remained significant at 12 weeks. The Outcome Measures in Rheumatology Clinical Trials-Osteoarthritis Research Society International responder rate was 65% in the intervention group and 34% in the placebo group (p < 0.05).Conclusion.Low-dose oral prednisolone had both a short-term and a longer sustained effect resulting in less knee pain, better physical function, and attenuation of systemic inflammation in older patients with knee OA (ClinicalTrials.govidentifierNCT01619163).
Prevalence, Correlates and Outcomes of Gastric Antral Vascular Ectasia in Systemic Sclerosis: A EUSTAR Case-control Study
Authors: Ghrénassia Etienne , Avouac Jérome , Khanna Dinesh , Derk Chris T. , Distler Oliver , Suliman Yossra Atef , Airo Paolo , Carreira Patricia E. , Foti Rosario , Granel Brigitte , Berezne Alice , Cabane Jean , Ingegnoli Francesca , Rosato Edoardo , Caramaschi Paola , Hesselstrand Roger , Walker Ulrich A. , Alegre-Sancho Juan Jose , Zarrouk Virginie , Agard Christian , Riccieri Valeria , Schiopu Elena , Gladue Heather , Steen Virginia D. , Allanore Yannick 
Published: December 2013

Objective.To estimate the prevalence, determine the subgroups at risk, and the outcomes of patients with systemic sclerosis (SSc) and gastric antral vascular ectasia (GAVE).Methods.We queried the European League Against Rheumatism Scleroderma Trials and Research (EUSTAR) network for the recruitment of patients with SSc-GAVE. Each case was matched for cutaneous subset and disease duration with 2 controls with SSc recruited from the same center, evaluated at the time the index case made the diagnosis of GAVE. SSc characteristics were recorded at the time GAVE occurred and the last observation was collected to define the outcomes.Results.Forty-nine patients with SSc and GAVE were included (24 with diffuse cutaneous SSc) and compared to 93 controls with SSc. The prevalence of GAVE was estimated at about 1% of patients with SSc. By multivariate analysis, patients with SSc-GAVE more frequently exhibited a diminished (< 75%) DLCO value (OR 12.8; 95% CI 1.9–82.8) despite less frequent pulmonary fibrosis (OR 0.2; 95% CI 0.1–0.6). GAVE was also associated with the presence of anti-RNA-polymerase III antibodies (OR 4.6; 95% CI 1.2–21.1). SSc-GAVE was associated with anemia (82%) requiring blood transfusion (45%). Therapeutic endoscopic procedures were performed in 45% of patients with GAVE. After a median followup of 30 months (range 1–113 months), survival was similar in patients with SSc-GAVE compared to controls, but a higher number of scleroderma renal crisis cases occurred (12% vs 2%; p = 0.01).Conclusion.GAVE is rare and associated with a vascular phenotype, including anti-RNA-polymerase III antibodies, and a high risk of renal crisis. Anemia, usually requiring blood transfusions, is a common complication.
The OMERACT-RAMRIS Rheumatoid Arthritis Magnetic Resonance Imaging Joint Space Narrowing Score: Intrareader and Interreader Reliability and Agreement with Computed Tomography and Conventional Radiography
Authors: Døhn Uffe Møller , Conaghan Philip G. , Eshed Iris , Boonen Annelies , Boyesen Pernille , Peterfy Charles G. , Lillegraven Siri , Ejbjerg Bo , Gandjbakhch Frederique , Bird Paul , Foltz Violaine , Genant Harry K. , Haavardsholm Espen , McQueen Fiona M. , Østergaard Mikkel 
Published: December 2013

Objective.To test the intrareader and interreader reliability of assessment of joint space narrowing (JSN) in rheumatoid arthritis (RA) wrist and metacarpophalangeal (MCP) joints on magnetic resonance imaging (MRI) and computed tomography (CT) using the newly proposed OMERACT-RAMRIS JSN scoring method, and to compare JSN assessment on MRI, CT, and radiography.Methods.After calibration of readers, MRI and CT images of the wrist and second to fifth MCP joints from 14 patients with RA and 1 healthy control were assessed twice for JSN by 3 readers, blinded to clinical and imaging data. Radiographs were scored by the Sharp/van der Heijde method. Intraclass correlation coefficients (ICC) and smallest detectable differences (SDD) were calculated, and the performance of various simplified scores was investigated.Results.Both MRI and CT showed high intrareader (ICC ≥ 0.95) and interreader (ICC ≥ 0.94) reliability for total (wrist + MCP) assessment of JSN. Agreement was generally lower for MCP joints than for wrist joints, particularly for CT. Intrareader SDD for MCP/wrist/MCP + wrist were 1.2/6.1/6.4 JSN units for MRI, while 2.7/8.3/9.9 JSN units for CT. JSN on MRI and CT correlated moderately well with corresponding radiographic JSN scores (MCP 2–5: 0.49 and 0.56; wrist areas assessed by Sharp/van der Heijde: 0.80 and 0.95), and high ICC between scores on MRI and CT were demonstrated (MCP: 0.94; wrist: 0.92; MCP + wrist: 0.92).Conclusion.The OMERACT-RAMRIS MRI JSN scoring system showed high intrareader and interreader reliability, and high correlation with CT scores of JSN. The suggested JSN score may, after further validation in longitudinal studies, become a useful tool in RA clinical trials.
Modèles neuropsychologiques dans l'autisme et les troubles envahissants du développement
Authors: Valeri Giovanni , Speranza Mario 
Published: December 2013

Résumé La recherche récente a apporté des nombreux arguments en faveur de l’existence de dysfonctionnements neuropsychologiques spécifiques impliqués dans l’étiopathogénèse des troubles du spectre de l’autisme. Cependant, un modèle conceptuel cohérent en mesure d’intégrer ces différents déficits avec les manifestations cliniques des troubles n’a pas a encore clairement émergé. Certains auteurs privilégient l’existance d’un déficit cognitif primaire responsable de l’ensemble des anomalies, cognitives et cliniques, observées ; d’autres favorisent l’hypothèse de déficits cognitifs multiples et indépendants. L’objectif de cet article est de présenter les trois principaux modèles neuropsychologiques validés à l’heure actuelle : le déficit de mentalisation (ou déficit en Théorie de l’Esprit), le déficit des Fonctions Exécutives (FE) et la Faible Cohérence Centrale (FCC), et de discuter de leurs implications cliniques dans la compréhension de l’autisme et des troubles envahissants du développement.
Développement de la dominance cérébrale : revue des données disponibles et proposition d'une hypothèse originale
Authors: Habib Michel 
Published: December 2013

Résumé Le terme de dominance hémisphérique (ou dominance cérébrale) est traditionnellement utilisé en neurologie pour faire référence aux processus présumés à l’origine de latéralisation hémisphérique du cerveau. La plupart des travaux menés dans ce domaine sont basés sur la constatation que, d’un point de vue strictement morphologique, les deux hémisphères diffèrent significativement, tant pour leur anatomie corticale que pour certaines régions sous-corticales. La question de la signification fonctionnelle de ces asymétries occupe le centre des débats, en particulier en ce qui concerne les deux fonctions les mieux connues comme latéralisées : la préférence manuelle (‘manualité’) et le langage. Sur ces deux points, les travaux les plus récents n’ont pas encore démontré de façon convaincante un lien univoque entre asymétries et latéralité. Concernant l’origine même des asymétries, il est probable que, bien que déjà présentes sur les cerveaux de nouveau-nés (et aussi de primates non humains), leurs mécanismes intimes ne soient qu’incomplètement déterminés par des facteurs génétiques ou prénatals. Au contraire, tout laisse penser que des facteurs liés au milieu, en particulier durant l’enfance, soient capables de moduler les caractéristiques ultérieures d’asymétrie cérébrale, et que l’asymétrie même des fonctions puisse induire une asymétrie des structures qui les contrôlent.
Test de rétention visuelle de Benton : étalonnage français auprès d'enfants âgés de 8 à 11 ans
Authors: Vallas Emmanelle , Bénesteau Jacques , Albaret Jean-Michel 
Published: December 2013

Résumé Le Test de Rétention Visuelle de Benton (BVRT) a été conçu pour évaluer les fonctions visuospatiales et la mémoire visuelle. Il comprend deux séries de procédures : reproduction graphique de figures géométriques et reconnaissance avec choix multiple. L’étalonnage présenté porte sur 281 enfants (152 filles et 129 garçons) âgés de 8 à 11 ans 11 mois et concerne les administrations A (exposition 10 secondes, puis reproduction immédiate de mémoire) et M (exposition 10 secondes, puis choix de mémoire parmi quatre possibilités). Aucune différence entre les sexes n’est retrouvée. Il y a par contre un effet de l’âge sur le nombre de dessins et le nombre de choix corrects qui augmentent et le nombre d’erreurs en administration A qui diminue. La fidélité test-retest est faible pour l’administration A, ce qui interdit toute utilisation trop rapprochée. Des études de validation pathologique restent à faire.
Lec et LO : lecture et langage oral. Une épreuve de lecture de texte en appui sur la psycholinguistique
Authors: Piérart Bernadette , Estienne Françoise 
Published: December 2013

Résumé L’épreuve de lecture orale d’un texte « Lec et LO » constitue le complément la Batterie de langage oral Isadyle . Les deux outils sont étalonnés sur le même échantillon de référence. Ce dispositif constitue un atout pour l’évaluation complémentaire des connaissances lexicales à l’oral et leur évocation rapide, de la compréhension orale des structures syntaxiques, de la phonologie, des capacités métaphonologiques et métasyntaxiques et de la mémoire verbale.
Le dessin de l'enfant et son usage dans la pratique psychologique
Authors: Picard Delphine , Baldy René 
Published: December 2013

Résumé Dans cet article, nous faisons le point sur le dessin de l’enfant tel qu’il peut être utilisé raisonnablement dans le cadre de la pratique psychologique. Dans un premier temps, nous proposons une classification des différents types de dessins utilisés couramment dans la pratique psychologique. Nous proposons ensuite une « mise en garde » contre certaines idées reçues (1- le dessin est le reflet direct d’un modèle interne, 2- le dessin du bonhomme témoigne de l’élaboration du schéma corporel, 3- le dessin, de par sa taille et ses couleurs, est une projection de l’état émotionnel du dessinateur, et 4- le dessin est universel et peu sensible aux variantes culturelles et historiques). Nous abordons finalement quelques perspectives contemporaines d’usage du dessin, notamment le dessin comme outil d’évaluation de la flexibilité cognitive, de la pensée divergente, et de la compréhension des émotions chez l’enfant.
La PMCC-CDG : Nouveau protocole de rééducation psychomotrice des Coordinations Dynamiques Générales basé sur la Pratique de Mouvements Continus et Cycliques appliqué au TAC
Authors: Aubert Éric , Pezet Émilie 
Published: December 2013

Le Trouble d’Acquisition de la Coordination (TAC) est un trouble moteur fréquent qui a des répercussions sur différents plans : scolaire, familial, de la vie quotidienne... En séances, le psychomotricien se retrouve très régulièrement face à des enfants porteurs d’un TAC. L’intérêt de ce protocole psychomoteur, nommé PMCC-CDG, est d’apprendre, à ces enfants incoordonnés, trois coordinations dynamiques générales saturées en paramètres existant dans la plupart des coordinations dynamiques générales. Ainsi, une généralisation sur d’autres coordinations dynamiques générales est attendue. Pour cela, cette rééducation se base sur la théorie dynamique du mouvement expliquant que les mouvements continus et cycliques sont plus stables que les mouvements sériels. Ainsi, l’apprentissage moteur de ces coordinations s’effectue de manière cyclique, c’est-à-dire que les coordinations ne sont pas apprises isolément, mais dans un enchaînement d’une même action motrice répétée régulièrement.
“They are human beings, they are Swazi”: intersecting stigmas and the positive health, dignity and prevention needs of HIV‐positive men who have sex with men in Swaziland
Authors: Kennedy Caitlin E , Baral Stefan D , Fielding‐Miller Rebecca , Adams Darrin , Dludlu Phumlile , Sithole Bheki , Fonner Virginia A , Mnisi Zandile , Kerrigan Deanna 
Published: December 2013

IntroductionDespite the knowledge that men who have sex with men (MSM) are more likely to be infected with HIV across settings, there has been little investigation of the experiences of MSM who are living with HIV in sub‐Saharan Africa. Using the framework of positive health, dignity and prevention, we explored the experiences and HIV prevention, care and treatment needs of MSM who are living with HIV in Swaziland.MethodsWe conducted 40 in‐depth interviews with 20 HIV‐positive MSM, 16 interviews with key informants and three focus groups with MSM community members. Qualitative analysis was iterative and included debriefing sessions with a study staff, a stakeholders’ workshop and coding for key themes using Atlas.ti.ResultsThe predominant theme was the significant and multiple forms of stigma and discrimination faced by MSM living with HIV in this setting due to both their sexual identity and HIV status. Dual stigma led to selective disclosure or lack of disclosure of both identities, and consequently a lack of social support for care‐seeking and medication adherence. Perceived and experienced stigma from healthcare settings, particularly around sexual identity, also led to delayed care‐seeking, travel to more distant clinics and missed opportunities for appropriate services. Participants described experiences of violence and lack of police protection as well as mental health challenges. Key informants, however, reflected on their duty to provide non‐discriminatory services to all Swazis regardless of personal beliefs.ConclusionsIntersectionality provides a framework for understanding the experiences of dual stigma and discrimination faced by MSM living with HIV in Swaziland and highlights how programmes and policies should consider the specific needs of this population when designing HIV prevention, care and treatment services. In Swaziland, the health sector should consider providing specialized training for healthcare providers, distributing condoms and lubricants and engaging MSM as peer outreach workers or expert clients. Interventions to reduce stigma, discrimination and violence against MSM and people living with HIV are also needed for both healthcare workers and the general population. Finally, research on experiences and needs of MSM living with HIV globally can help inform comprehensive HIV services for this population.
Ceria Zirconia Mixed Oxides Prepared by Hydrothermal Templating Method for the Oxidation of Ethyl Benzene
Authors: Daniel Cimi A. , Sugunan S. 
Published: December 2013

CeO2–ZrO2 oxides were prepared by the surfactant-templated method using cetyl trimethyl ammonium bromide (CTAB) as template. These were characterized by XRD, FT-IR, TEM, SEM, BET and TPD-CO2. The XRD data showed that as prepared CeO2-ZrO2 powder particles have single phase cubic fluorite structure. HRTEM shows mesoscopic ordering. Average particle size is 12-13 nm as calculated from particle histogram. The nitrogen adsorption/desorption isotherm were classified to be type IV isotherm, typical of mesoporous material. The presence of uni-modal mesopores are confirmed by the pore size distribution which shows pore distribution at around 60 A°. The catalytic activities of the prepared material were tested in liquid phase oxidation of ethylbenzene with tert-butyl hydroperoxide (TBHP) as an oxidant. Ceria zirconia catalyst modified with chromium was active for ethylbenzene conversion (65.3%) with 77% selectivity towards acetophenone. © 2013 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Application of Factorial Design of Experiments for the Continuous Hydrogenation of Enriched Castor Oil Methyl Esters
Authors: Neeharika Tulasi Sri Venkata Ramana , Rani Karna Narayana Prasanna , Rao Kasturi Venkata Sesha Adinarayana , Kumar Thella Prathap , Prasad Rachapudi Badari Narayana 
Published: December 2013

Castor oil methyl esters contains nearly 90% ricinoleic acid (12-hydroxy-cis-9-octadecenoic acid). Hydrogen-ated castor oil methyl esters finds several applications in coating, lubricants formulations and pharmaceu-tical areas. The present study reports a fast, simple, efficient and continuous hydrogenation of enriched castor oil methyl ester (ECME) using 10% Pd/C catalyst at different pressures and temperatures. The range of process conditions for this study varied from 30-60 °C, 5-15 bar with constant flow rate of 15 ml/min. The products were analyzed for fatty acid composition and iodine value (IV). The optimized pa-rameters were found to be a temperature of 30 °C, pressure 5 bar, and flow rate of 15 ml/min where maxi-mum hydrogenation of 98.47 % was obtained and the product showed an iodine value of 3.19. © 2013 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Characterization of the Picrotoxin Site of GABAA Receptors
Authors: Mehta Ashok K. , Ticku Maharaj K. 
Published: December 2013

AbstractThis unit describes an in vitro assay for characterization of the picrotoxin site of GABAA receptors in rat brain membranes using various radioligands. Methods and representative data for Scatchard analysis (K
d, B
max determination), association kinetics, dissociation kinetics, and competition assays (IC50, K
i determination) are included. Curr. Protoc. Pharmacol. 63:1.18.1‐1.18.18. © 2013 by John Wiley & Sons, Inc.
Analysis of Cell‐Cell Contact Mediated by Ig Superfamily Cell Adhesion Molecules
Authors: Stoeckli Esther T. , Kilinc Devrim , Kunz Beat , Kunz Stefan , Lee Gil U. , Martines Elena , Rader Christoph , Suter Daniel 
Published: December 2013

AbstractCell‐cell adhesion is a fundamental requirement for all multicellular organisms. The calcium‐independent cell adhesion molecules of the immunoglobulin superfamily (IgSF‐CAMs) represent a major subgroup. They consist of immunoglobulin folds alone or in combination with other protein modules, often fibronectin type‐III folds. More than 100 IgSF‐CAMs have been identified in vertebrates and invertebrates. Most of the IgSF‐CAMs are cell surface molecules that are membrane‐anchored either by a single transmembrane segment or by a glycosylphosphatidylinositol (GPI) anchor. Some of the IgSF‐CAMs also occur in soluble form, e.g., in the cerebrospinal fluid or in the vitreous fluid of the eye, due to naturally occurring cleavage of the GPI anchor or the membrane‐proximal peptide segment. Some IgSF‐CAMs, such as NCAM, occur in various forms that are generated by alternative splicing. This unit contains a series of protocols that have been used to study the function of IgSF‐CAMs in vitro and in vivo. Curr. Protoc. Cell Biol. 61:9.5.1‐9.5.85. © 2013 by John Wiley & Sons, Inc.
A nonstorm time enhancement of relativistic electrons in the outer radiation belt
Authors: Schiller Quintin , Li Xinlin , Blum Lauren , Tu Weichao , Turner Drew L. , Blake J. B. 
Published: December 2013

AbstractDespite the lack of a geomagnetic storm (based on the Dst index), relativistic electron fluxes were enhanced over 2.5 orders of magnitude in the outer radiation belt in 13 h on 13–14 January 2013. The unusual enhancement was observed by Magnetic Electron Ion Spectrometer (MagEIS), onboard the Van Allen Probes; Relativistic Electron and Proton Telescope Integrated Little Experiment, onboard the Colorado Student Space Weather Experiment; and Solid State Telescope, onboard Time History of Events and Macroscale Interactions during Substorms (THEMIS). Analyses of MagEIS phase space density (PSD) profiles show a positive outward radial gradient from 4 < L < 5.5. However, THEMIS observations show a peak in PSD outside of the Van Allen Probes' apogee, which suggest a very interesting scenario: wave‐particle interactions causing a PSD peak at ~ L* = 5.5 from where the electrons are then rapidly transported radially inward. This letter demonstrates, for the first time in detail, that geomagnetic storms are not necessary for causing dramatic enhancements in the outer radiation belt.
Geology and composition of the Orientale Basin impact melt sheet
Authors: Spudis Paul D. , Martin Dayl J. P. , Kramer Georgiana 
Published: November 2013

AbstractThe Orientale Basin is one of the largest (930 km diameter) and youngest (~3.8 Ga) impact craters on the Moon. As the basin is only partly flooded by mare lava, its floor materials expose a major portion of the basin impact melt sheet, which some previous work has suggested might have undergone igneous differentiation. To test this idea, we remapped the geology of the Orientale Basin using images and topography from the Lunar Reconnaissance Orbiter, mineralogical information from the Chandrayaan‐1 Moon Mineralogy Mapper, and elemental concentration maps from Clementine multispectral imaging and Lunar Prospector gamma ray data. The Maunder Formation (impact melt sheet of the basin) is uniform in chemical composition (equivalent to “anorthositic norite”) in at least the upper 2 km of the deposit. The deepest sampling of the basin melt sheet (maximum depths of ~3–5 km by the crater Maunder, 55 km in diameter) shows a variety of lithologies, but these rock types (anorthosite, anorthositic norite melt rocks, mare basalt, and gabbro) are not those predicted by the differentiation model. We conclude that no differentiation of the Orientale Basin melt sheet has occurred and that such a process is not evident from new remote sensing data for the Moon or in the Apollo lunar samples.