bluuebunny/crossref_metadata_2025_split huggingface dataset:
A QoS enabled multimedia WiFi access point
Authors: O Flaithearta Padraig , Melvin Hugh , Schukat Michael 
Published: May 2015

SummaryThe Internet has evolved to a stage where the number of Internet enabled devices exceeds the global population. With much of the required connectivity over wireless, contention for bandwidth is an important issue that has to be addressed. In this context, applications that have certain quality of service (QoS) requirements must be protected. WiFi‐enabled mobile devices such as smartphones and tablets are commonly used by both personal and business users for voice over IP (VoIP) communications, while also supporting conventional data applications such as email, file transfer and web access. Previous research has shown that time synchronized endpoints can provide better QoS by calculating accurate mouth‐to‐ear delays, and using this information to better inform buffer playout strategies. The IEEE 802.11e protocol extends 802.11 by providing different traffic priorities based on traffic type. However, it cannot distinguish between traffic streams within the same category. In this paper, we present an access point‐centred mechanism for further distinguishing between streams within 802.11e categories. The mechanism predicts the VoIP quality for multiple sessions using the ITU‐T E‐Model. Delay values are determined from RTCP packet timing information. We provide implementation details on a real world proof‐of‐concept and present results that correlate well with previous NS‐3 based simulations. In addition, we address scalability issues for large scale deployments. Copyright © 2015 John Wiley & Sons, Ltd.
An Exceptional Case of Healed Vertebral Wound with Trapped Bronze Arrowhead: Analysis of a 7th–6th c. bc Individual from Central Kazakhstan
Authors: Tur S. S. , Svyatko S. V. , Beisenov A. Z. , Tishkin A. A. 
Published: May 2015

AbstractProjectile injury caused by an arrow shot is a common skeletal marker of interpersonal violence in archaeological populations. The injuries of the spine were usually fatal. Only few reports on healing of the vertebra pierced by flint arrowpoint can be found in bioarchaeological literature. This paper presents an exceptional case of a healed trapped bronze arrowhead wound in the spine of a 7th–6th c. bc elite nomad from Central Kazakhstan. Computed radiography and tomography as well non‐destructive X‐ray fluorescence spectrometry provide detailed information about the context and mechanism of the injury. Copyright © 2015 John Wiley & Sons, Ltd.
Microenvironmental control of stem cell fate in intestinal homeostasis and disease
Authors: Biswas Sujata , Davis Hayley , Irshad Shazia , Sandberg Tessa , Worthley Daniel , Leedham Simon 
Published: May 2015

AbstractThe conventional model of intestinal epithelial architecture describes a unidirectional tissue organizational hierarchy with stem cells situated at the crypt base and daughter cells proliferating and terminally differentiating as they progress along the vertical (crypt–luminal) axis. In this model, the fate of a cell that has left the niche is determined and its lifespan limited. Evidence is accumulating to suggest that stem cell control and daughter cell fate determination is not solely an intrinsic, cell autonomous property but is heavily influenced by the microenvironment including paracrine, mesenchymal, and endogenous epithelial morphogen gradients. Recent research suggests that in intestinal homeostasis, stem cells transit reversibly between states of variable competence in the niche. Furthermore, selective pressures that disrupt the homeostatic balance, such as intestinal inflammation or morphogen dysregulation, can cause committed progenitor cells and even some differentiated cells to regain stem cell properties. Importantly, it has been recently shown that this disruption of cell fate determination can lead to somatic mutation and neoplastic transformation of cells situated outside the crypt base stem cell niche. This paper reviews the exciting developments in the study of stem cell dynamics in homeostasis, intestinal regeneration, and carcinogenesis, and explores the implications for human disease and cancer therapies. © 2015 Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Evaluation of an ICD‐10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients
Authors: Ehrenstein Vera , Gammelager Henrik , Schiødt Morten , Nørholt Sven Erik , Neumann‐Jensen Bjarne , Folkmar Troels Bille , Pedersen Lars , Sværke Claus , Sørensen Henrik Toft , Ma Haijun , Acquavella John 
Published: May 2015

AbstractPurposeThis study aimed to validate a predefined algorithm for osteonecrosis of the jaw (ONJ) among cancer patients in the Danish National Registry of Patients and to assess the nature of clinical information recorded in medical charts of ONJ patients.MethodsWe identified potential ONJ cases recorded in 2005–2010 among cancer patients at the hospital Departments of Oral and Maxillofacial Surgery (DOMS) in three Danish regions, using a set of codes from the International Classification of Diseases, 10th revision (ICD‐10). We abstracted DOMS charts of the potential cases, had the ONJ status adjudicated by an expert ONJ adjudication committee (ONJAC), and computed positive predictive values. For patients with ONJAC‐confirmed ONJ, we abstracted the charts for information on ONJ clinical course. Sensitivity of the algorithm was computed using a separate sample of 101 known ONJ cases accrued in 2005–2011.ResultsWe identified 212 potential ONJ cases, of which 197 (93%) had charts available for abstraction. Eighty‐three potential cases were confirmed by ONJAC, with a positive predictive value of 42% (95% confidence interval [CI] 35%–49%). DOMS charts of these 83 cases contained complete information on ONJ clinical course. Information about antiresorptive treatment was recorded for 84% of the patients. Among the 101 known ONJ cases, 74 had at least one prespecified ICD‐10 code recorded in the Danish National Registry of Patients within ±90 days of the ONJ diagnosis (sensitivity 73%; 95%CI [64%–81%]).ConclusionsThe predefined algorithm is not adequate for monitoring ONJ in pharmacovigilance studies. Additional case‐finding approaches, coupled with adjudication, are necessary to estimate ONJ incidence accurately. Copyright © 2015 John Wiley & Sons, Ltd.
Redox initiated cationic polymerization of oxetanes
Authors: Crivello James V. 
Published: May 2015

ABSTRACT3,3‐Disubstituted oxetane monomers were found to undergo rapid, exothermic redox initiated cationic ring‐opening polymerization in the presence of a diaryliodonium or triarylsulfonium salt oxidizing agent and a hydrosilane reducing agent. The redox reaction requires a noble metal complex as a catalyst and several potential catalysts were evaluated. The palladium complex, Cl2(COD)PdII, was observed to provide good shelf life stability while, at the same time, affording high reactivity in the presence of a variety of hydrosilane reducing agents. A range of structurally diverse oxetane monomers undergo polymerization under redox cationic conditions. When a small amount of an alkylated epoxide was added as a “kick‐start” accelerator to these same oxetanes, the redox initiated cationic polymerizations were extraordinarily rapid owing to the marked reduction in the induction period. A mechanistic interpretation of these results is offered. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 1854–1861
Body image and sexual function in women after treatment for anal and rectal cancer
Authors: Benedict Catherine , Philip Errol J. , Baser Raymond E. , Carter Jeanne , Schuler Tammy A. , Jandorf Lina , DuHamel Katherine , Nelson Christian 
Published: May 2015

AbstractObjectiveTreatment for anal and rectal cancer (ARCa) often results in side effects that directly impact sexual functioning; however, ARCa survivors are an understudied group, and factors contributing to the sexual sequelae are not well understood. Body image problems are distressing and may further exacerbate sexual difficulties, particularly for women. This preliminary study sought to (1) describe body image problems, including sociodemographic and disease/treatment correlates, and (2) examine relations between body image and sexual function.MethodsFor the baseline assessment of a larger study, 70 women completed the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire and Colorectal Cancer‐specific Module, including the Body Image subscale, and Female Sexual Function Index. Pearson's correlation and multiple regression evaluated correlates of body image. Among sexually active women (n = 41), hierarchical regression examined relations between body image and sexual function domains.ResultsWomen were on average 55 years old (standard deviation = 11.6), non‐Hispanic White (79%), married (57%), and employed (47%). The majority (86%) reported at least one body image problem. Younger age, lower global health status, and greater severity of symptoms related to poorer body image (p's < 0.05). Poor body image was inversely related to all aspects of sexual function (β range 0.50–0.70, p's < 0.05), except pain. The strongest association was with Female Sexual Function Index Sexual/Relationship Satisfaction.ConclusionThese preliminary findings suggest the importance of assessing body image as a potentially modifiable target to address sexual difficulties in this understudied group. Further longitudinal research is needed to inform the development and implementation of effective interventions to improve the sexual health and well‐being of female ARCa survivors. Copyright © 2015 John Wiley & Sons, Ltd.
E‐Books and Audiobooks
Authors: Larson Lotta C. 
Published: May 2015

AbstractThis article examines how sixth‐grade students navigated and perceived a combined e‐book and audiobook reading experience using Kindle Fires. While audiobooks and e‐books are not new, little is known about students' use and perceptions of the combination of these two media, as the ability to synchronize audio contents with digital texts is rather innovative. In this study, students used e‐book tools and features to customize the reading experience to suit individual needs. They also utilized Immersion Reading to listen to a professional narration and simultaneously read the digital text with synchronized highlighting. For many students, the combined reading/listening experience supported their reading stamina, vocabulary development, and reading motivation. Recent advancements in e‐book technologies call for an aggressive research agenda and further studies to help students and educators effectively integrate digital reading across content areas.
At the interface of computational linguistics and statistics
Authors: Martinez Angel , Martinez Wendy 
Published: May 2015

Computational linguistics encompasses a broad range of ideas and research areas, and only a brief introduction is possible here. We chose to include areas in computational linguistics where statisticians can contribute, hoping to provide inspiration to the reader. We describe three main aspects of this discipline—formal languages, information retrieval, and machine learning. These support the overarching goal, which is the representation and analysis of meaning from unstructured text. We then provide an example where text analysis has been applied to unstructured text fields in survey records and conclude with some applications and computational resources.WIREs Comput Stat2015, 7:258–274. doi: 10.1002/wics.1353This article is categorized under:Applications of Computational Statistics > Computational LinguisticsSoftware for Computational Statistics > Artificial Intelligence and Expert Systems
Screening Men with Coronary Heart Disease for Abdominal Aortic Aneurysm: A Prospective Cohort Study
Authors: Vänni Ville , Hernesniemi Jussi , Turtiainen Matti , Turtiainen Johanna , Hakala Tapio 
Published: May 2015

AbstractBackgroundThe prevalence of abdominal aortic aneurysms (AAA) is higher among patients with coronary heart disease (CHD) compared with control population.ObjectiveTo assess and determine the prevalence of non‐diagnosed AAA in men with CHD.Materials and methodsA total of 438 active male out‐patients with CHD were screened for AAA by abdominal ultrasound (US) examination. The largest infrarenal aortic dimension was registered. The patient was regarded to have AAA when the aortic diameter was greater than 30 mm.ResultsWe found altogether 25 AAAs. The incidence of AAA was 5.7 %. One AAA patient was operated on, and the other AAA patients are under surveillance. Independent predictors for AAA among CHD patients were increased age, family history of AAA, and current or previous smoking. The screening process took on average 5 min per patient, and the cost of screening was 15€ ($18.50) per patient or €257 ($325) per found AAA.ConclusionsThe prevalence of previously undiagnosed AAAs among patients with CHD is considerable. Screening of AAA should be considered among active patients with CHD. The most feasible and simplest option would be to perform the screening during any routine or elective cardiac US by a cardiologist, and we recommend to adopt it as a standard practice.
Association between air pollutants and dementia risk in the elderly
Authors: Wu Yun‐Chun , Lin Yuan‐Chien , Yu Hwa‐Lung , Chen Jen‐Hau , Chen Ta‐Fu , Sun Yu , Wen Li‐Li , Yip Ping‐Keung , Chu Yi‐Min , Chen Yen‐Ching 
Published: May 2015

AbstractBackgroundThe aging rate in Taiwan is the second highest in the world. As the population ages quickly, the prevalence of dementia increases rapidly. There are some studies that have explored the association between air pollution and cognitive decline, but the association between air pollution and dementia has not been directly evaluated.MethodsThis was a case‐control study comprising 249 Alzheimer's disease (AD) patients, 125 vascular dementia (VaD) patients, and 497 controls from three teaching hospitals in northern Taiwan from 2007 to 2010. Data of particulate matter <10 μm in diameter (PM10) and ozone were obtained from the Taiwan Environmental Protection Administration for 12 and 14 years, respectively. Blood samples were collected to determine the apolipoprotein E (APOE) ɛ4 haplotype. Bayesian maximum entropy was used to estimate the individual exposure level of air pollutants, which was then tertiled for analysis. Conditional logistic regression models were used to estimate adjusted odds ratios (AORs) and 95% confidence intervals between the association of PM10 and ozone exposure with AD and VaD risk.ResultsThe highest tertile of PM10 (≥49.23 μg/m3) or ozone (≥21.56 ppb) exposure was associated with increased AD risk (highest vs. lowest tertile of PM10: AOR = 4.17; highest vs. lowest tertile of ozone: AOR = 2.00). Similar finding was observed for VaD. The association with AD and VaD risk remained for the highest tertile PM10 exposure after stratification by APOE ɛ4 status and gender.ConclusionsLong‐term exposure to the highest tertile of PM10 or ozone was significantly associated with an increased risk of AD and VaD.
The misforecasted spoiler effect: Underlying mechanism and boundary conditions
Authors: Yan Dengfeng , Tsang Alex S.L. 
Published: May 2015

AbstractWhile consumers believe that knowing the ending of a story will spoil their enjoyment of the narrative, recent work shows that spoilers have little impact on consumers' actual experiences. The psychological mechanism underlying this affective misforecasting, however, is less clear. In this research, we propose that compared with real experience, affective forecasting may be associated with longer psychological distance and high‐level construal, which may encourage forecasters to assign greater weight to the outcome of a plot. In addition to showing the basic effect, we also identify circumstances under which such affective misforecasting is less likely to happen or even reverses. In line with our theorizing, the results of two studies showed that the misforecasting disappeared when participants had chronic or situationally primed low (vs. high) construal levels. In the final experiment we reversed the previous finding, showing that participants underpredicted the negative impact of a spoiler when the spoiler revealed the process of a plot.
“Our Forces Have Redoubled”: World Literature, Postcolonialism, and the Afro-Asian Writers’ Bureau
Authors: Yoon Duncan M. 
Published: May 2015

AbstractAlthough most all contemporary studies of China and Africa focus on current economic or foreign policy concerns, this article provides a preliminary mapping of Africa-China cultural exchanges during the Cold War. Growing out of the Africa-Asia Conference of Bandung, Indonesia, in 1955, the Afro-Asian Writers Bureau forged third world solidarities via an alternative conception of postcolonialism based on the transnationalism of global South cultural struggle. By analyzing the cultural exchanges of the bureau, and in particular their definition ofworld literature, this article seeks to move beyond postcolonial scholarship that focuses exclusively on a vertical relationship between the colonizer and colonized. In so doing, it both reinterprets the Cold War from outside of an American and Soviet dichotomy and provides a critical cultural historicization to China’s current, and often controversial, presence in Africa.
Imaging with penetrating radiation for the study of small dynamic physical processes
Authors: Merrill F. E. 
Published: May 2015

AbstractSince Roentgen's discovery of X rays in the late 1800s the use of penetrating radiation to form images has become a part of our everyday life as well as providing a useful tool for the scientific study of processes that have been previously impossible to measure. This can include the study of processes that are too deeply embedded in opaque materials for direct observation, or that occur on a length or time scale smaller than otherwise can be easily measured. As technologies to generate penetrating radiation and quickly collect images have matured, new techniques have emerged to measure processes that have been hidden for many years. One example is advances in flash radiography using charged particles as radiographic probes, including proton radiography and electron radiography. Recently the successful commissioning of proton microscope systems has provided remarkable improvements in spatial resolution. These techniques are being implemented for applications with electron radiography. With the evolution of these new techniques comes the opportunity to choose the probe that provides the maximum information for the desired measurement. This paper describes these new imaging techniques, predicts the capabilities of high-energy electron radiography, and provides a guide for identifying the optimal probe for a wide range of measurements.
XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death
Authors: Oishi N , Duscha S , Boukari H , Meyer M , Xie J , Wei G , Schrepfer T , Roschitzki B , Boettger E C , Schacht J 
Published: May 2015

AbstractHere we study links between aminoglycoside-induced mistranslation, protein misfolding and neuropathy. We demonstrate that aminoglycosides induce misreading in mammalian cells and assess endoplasmic reticulum (ER) stress and unfolded protein response (UPR) pathways. Genome-wide transcriptome and proteome analyses revealed upregulation of genes related to protein folding and degradation. Quantitative PCR confirmed induction of UPR markers including C/EBP homologous protein, glucose-regulated protein 94, binding immunoglobulin protein and X-box binding protein-1 (XBP1) mRNA splicing, which is crucial for UPR activation. We studied the effect of a compromised UPR on aminoglycoside ototoxicity in haploinsufficient XBP1 (XBP1+/−) mice. Intra-tympanic aminoglycoside treatment caused high-frequency hearing loss in XBP1+/− mice but not in wild-type littermates. Densities of spiral ganglion cells and synaptic ribbons were decreased in gentamicin-treated XBP1+/− mice, while sensory cells were preserved. Co-injection of the chemical chaperone tauroursodeoxycholic acid attenuated hearing loss. These results suggest that aminoglycoside-induced ER stress and cell death in spiral ganglion neurons is mitigated by XBP1, masking aminoglycoside neurotoxicity at the organismal level.
Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cells
Authors: Qin Zhao , Hubbard E. Jane Albert 
Published: May 2015

AbstractStem cells maintain tissues and organs over the lifespan of individuals. How aging influences this process is unclear. Here we investigate the effects of aging on C. elegans germline stem/progenitor cells and show that the progenitor pool is depleted over time in a manner dependent on inhibition of DAF-16/FOXO by insulin/IGF-1 signalling (IIS). Our data indicate that DAF-16/FOXO activity in certain somatic gonad cells is required for germline progenitor maintenance, and that this role is separable from the effect of DAF-16/FOXO on organismal aging. In addition, blocking germ cell flux, similar to reducing IIS, maintains germline progenitors. This effect is partially dependent on gonadal DAF-16/FOXO activity. Our results imply that (1) longevity pathways can regulate aging stem cells through anatomically separable mechanisms, (2) stem cell maintenance is not necessarily prioritized and (3) stem cell regulation can occur at the level of an entire organ system such as the reproductive system.
Green fluorescent protein nanopolygons as monodisperse supramolecular assemblies of functional proteins with defined valency
Authors: Kim Young Eun , Kim Yu-na , Kim Jung A. , Kim Ho Min , Jung Yongwon 
Published: May 2015

AbstractSupramolecular protein assemblies offer novel nanoscale architectures with molecular precision and unparalleled functional diversity. A key challenge, however, is to create precise nano-assemblies of functional proteins with both defined structures and a controlled number of protein-building blocks. Here we report a series of supramolecular green fluorescent protein oligomers that are assembled in precise polygonal geometries and prepared in a monodisperse population. Green fluorescent protein is engineered to be self-assembled in cells into oligomeric assemblies that are natively separated in a single-protein resolution by surface charge manipulation, affording monodisperse protein (nano)polygons from dimer to decamer. Several functional proteins are multivalently displayed on the oligomers with controlled orientations. Spatial arrangements of protein oligomers and displayed functional proteins are directly visualized by a transmission electron microscope. By employing our functional protein assemblies, we provide experimental insight into multivalent protein–protein interactions and tools to manipulate receptor clustering on live cell surfaces.