bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harms of introduced large herbivores outweigh their benefits, while both are greater on islands and for higher trophic levels
Authors: Bescond--Michel Zoé , Bacher Sven , Vimercati Giovanni 
Published: August 2024

Abstract

Introduced species significantly impact native biodiversity worldwide, with extensive research on harms but relatively less focus on benefits. Using the IUCN Environmental Impact Classification for Alien Taxa (EICAT) and EICAT + frameworks, we assessed 2021 negative and positive impacts of introduced large mammalian herbivores globally. Negative impacts were more common and of higher magnitude than positive impacts, i.e. affected populations, not only the performance of individuals. Native species on islands and at higher trophic level experienced greater impacts. Reported impact magnitudes declined over time only for positive impacts. Most positive impacts were caused indirectly through changes in species interactions and ecosystem properties, often following negative impacts on native plants through herbivory and disturbance. We therefore caution against the intentional introduction of large mammalian herbivores for conservation purposes (rewilding, assisted colonization) without rigorous assessment of their impacts on native communities.
OS FATORES QUE INFLUENCIAM A FALTA DE ADESÃO AO TRATAMENTO DA TUBERCULOSE: REVISÃO INTEGRATIVA
Authors: Carvalho Bilio de Sousa Gislayne , Victor de Araújo Silva João , Cristina Doria dos Santos Ana 
Published: August 2024

A tuberculose (TB) é uma patologia causada pelo Mycobacterium tuberculosis, também chamado, bacilo de Koch. Sua transmissão ocorre através de aerossóis e pode afetar principalmente os pulmões, apesar de poder atingir outros órgãos e/ou sistemas. Nesse contexto, a cada ano são notificados cerca de 70 mil novos casos e cerca de 4,5 mil mortes devido à tuberculose. Consistiu em uma revisão integrativa em que se estabeleceu a temática e em seguida a formação da questão norteadora a qual direcionaria todo o corpo do trabalho, além da busca por artigos. Em seguida, estabeleceu-se os critérios de inclusão e exclusão dos artigos, com intuito de selecionar aqueles que se encaixariam ou não que no que foi exigido como guia do assunto desse trabalho. No intento de conduzir essa pesquisa, estabeleceu-se a seguinte indagação: quais as dificuldades existentes na adesão ao tratamento da tuberculose? Por meio de seis artigos, foram identificadas a influência de fatores que diminuem a adesão ao atendimento, como o uso de álcool; interrupção de benefícios, tratamento autoadministrado, falta de suporte familiar, fragilidade no vínculo entre doente e profissional e ausência de trabalho em equipe nos serviços de saúde. Além disso, a atuação da Estratégia Saúde da Família é fundamental nessa adesão, já que possui a lógica de produção do cuidado e direciona-se, também, pelo cumprimento das dimensões do que se define como acesso e vínculo, como a importância do Tratamento Diretamente Observado (TOD). Portanto, essa revisão, buscou explicitar quais os principais motivos responsáveis por esse abandono do tratamento. Pode-se implantar medidas cabíveis a fim de mitigar essa problemática, como campanhas que informem a população em geral sobre o que é, como ocorre a transmissão e sobre a gravidade da doença, se não tratada, em forma de cartilha informativa, por exemplo.
ACOMPANHAMENTO DO ENFERMEIRO A PORTADORES DE ESCLEROSE MÚLTIPLA: TRANSFORMANDO O CUIDADO
Authors: Bruno Henrique Souza Izidório  , Isabella de Carvalho Salviete  , Kamilla Silva Cretton  , Rafaela Silva Dias  
Published: August 2024

Objetivo: Observar e analisar o conhecimento no que se relaciona ao acompanhamento do enfermeiro no cuidado para com pacientes de diagnóstico ativo para Esclerose Múltipla. Métodos: Trata-se de uma abordagem qualitativa, de caráter descritivo, partindo de uma pesquisa integrativa. Utilizou-se um corte temporal entre 2013 e 2023, realizando uma busca na base de dados BVS, baseando nos descritores em saúde, Esclerose Múltipla, Cuidados de Enfermagem, Promoção da Saúde, Processo de Enfermagem. Resultados: Foram encontrados 09 artigos, onde se formalizou para criação do trabalho. Contudo, evidencia-se que, a Esclerose Múltipla se tornou uma doença, cujo, profissional enfermeiro tem de se tornar atuante na promoção e evolução do cuidado, já que o mesmo possui saberes técnico-científicos que o torna capaz de evoluir no que tange a continuidade do tratamento como forma de humanização. Conclusão: Contudo, observamos que, o profissional enfermeiro torna-se cada vez mais pautador na qualidade do cuidado prestado a pacientes portadores de Esclerose Múltipla, de forma que a evolução, promoção e continuidade, se estenda aos familiares, que também prestarão a assistência desejada.
Descritores: Esclerose Múltipla, Cuidados de Enfermagem, Promoção da Saúde, Processo de Enfermagem.
Comparative Study: Analysis of the Implementation of Sustainable Distribution of Funds for Sharia Banks and Conventional Banks in Indonesia
Authors: Nihayah Ana Zahrotun , Rifqi Lathif Hanafir 
Published: August 2024

Purpose - This research aims to identify the application of sustainable finance in sharia banks and conventional banks and identify obstacles in the application of sustainable finance.Method - The method used in this research is qualitative with a descriptive design. The type of descriptive design method used is a comparative study.Result - The research results show that the implementation of sustainable finance as represented by the allocation of financing at conventional banks (BRI) reached 65.5%, higher than sharia banks (BSI) which only reached 26.95%. the establishment of rules and regulations that are not yet comprehensive in the financial sector, low financial inclusion, low sustainable finance literacy, lack of common perception in financial institutions, the difficulty of balancing economic, social and environmental aspects and low market potential in lending to environmentally sound companies. Implication - This research was conducted to provide an explanation of the implementation of sustainable distribution of funds in Sharia banks and conventional banks and its challenges. Originality - Several previous studies have discussed sustainable finance in banking. However, there are still few discussing the comparison of the implementation of sustainable finance and the risks involved.
Pengaruh Good Corporate Governance terhadap Harga Saham Perusahaan Manufaktur Periode 2017-2022
Authors: Arifin Adhyasta Izhar Resvara , Rosidi Rosidi 
Published: August 2024

This study aims to investigate the influence of several proxies of Good Corporate Governance (GCG), namely Foreign Ownership, Institutional Ownership, Board of Commissioners, and Audit Committee, on the stock prices of manufacturing sector companies. The research sample consists of 45 manufacturing sector companies listed on the Indonesia Stock Exchange (IDX) during the period 2017-2022. The sampling technique used is purposive sampling, and the final sample obtained is 45 companies. The analysis method employed in this study is multiple linear regression analysis conducted using IBM SPSS 25 software. The results of the study indicate that Institutional Ownership and the Board of Commissioners have a positive influence on the company's stock price. This suggests that the larger the institutional ownership and the more effective the function of the board of commissioners, the more likely the stock price will increase. Conversely, the study found that Foreign Ownership and the Audit Committee do not have a significant impact on stock prices. This means that even if a company has high foreign ownership or an active audit committee, these factors do not directly affect the fluctuations in the company's stock price.

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‘They're telling us it's safe, but how do we know it's safe?’ Different stakeholder perspectives on drinking water safety
Authors: Anderson Heather K. , Quilliam Richard , Price Heather 
Published: August 2024

ABSTRACT
Current definitions of ‘safe’ drinking water and their inclusion in metrics for monitoring progress towards SDG 6.1 (universal access to safe drinking water) are inadequate as they fail to account for the way safety is understood and enacted in people's day-to-day lives. The aim of this study was to characterise the factors that influence what people understand by ‘safe’ drinking water and to identify opportunities to account for non-scientific/alternative ways of understanding ‘safety’ in the provision of drinking water. We used a case study from Scotland where residents have challenged water professionals over the safety of their drinking water. Semi-structured interviews (n = 30) were conducted with people involved in this case, and each participant was asked to draw ‘safe drinking water’. Although many differences between the stakeholders were identified, the drawing exercise revealed that the residents and water professionals alike believed that consumer satisfaction was vital for believing it was safe. Overall, we found that different knowledge, priorities and epistemologies contributed to different perspectives on drinking water safety. In the future, we propose that more transdisciplinary and citizen-centric ways of working are adopted to improve outcomes in the pursuit of SDG 6.1.
Pharmacokinetic Assessments of Ursolic Loaded-Dendrimer Complex
Authors: Singh Aditya , Ansari Vaseem Ahamad , Ansari Tarique Mahmood , Wasim Rufaida , Akhtar Juber , Maheshwari Shubhrat 
Published: August 2024

Background:
This study investigates the application of polyamidoamine (PAMAM)
dendrimers as an innovative drug delivery approach for enhancing the pharmacokinetic profile
of ursolic acid (UA), a pentacyclic triterpenoid with multifaceted therapeutic properties. UA,
sourced from plants like Sanguisorba officinalis and Salvia officinalis, has been extensively
studied for its pharmacological characteristics, including anti-inflammatory, antioxidant, and
anti-diabetic properties, as recognized in Traditional Chinese Medicine (TCM). The clinical
utility of UA is hampered by low bioavailability, which is attributed to its hydrophobic nature.
To address this limitation, we explore the use of PAMAM dendrimers, known for their drug
delivery potential.

Methods:
The UA-PAMAM G0 dendrimers were synthesized with varying molar ratios. Characterization
included size analysis, PDI, and zeta potential determination. FTIR confirmed the
chemical structure. Male SD rats were acclimatized and administered UA control suspension
and UA-G0 dendrimer complex orally. Blood samples were collected for pharmacokinetic
analysis. The study obtained IAEC approval.

Results:
The UA-PAMAM G0 dendrimer complexes exhibited varying sizes based on molar
ratios, with the 2:1 ratio showing significantly smaller dimensions. FTIR confirmed successful
conjugation. In the pharmacokinetic study, the UA-G0 dendrimer complex demonstrated higher
plasma concentrations than UA alone, as indicated by increased Cmax and AUC values. The
results suggest enhanced oral delivery and bioavailability of UA in the dendrimer complex.

Conclusion:
This study demonstrated the successful synthesis of UA-PAMAM G0 dendrimer
complexes with size variations based on molar ratios. The pharmacokinetic analysis revealed
improved plasma concentrations and bioavailability of UA in the dendrimer complex compared
to UA alone. These findings highlight the potential of PAMAM dendrimers for enhancing the
oral delivery of hydrophobic compounds like UA, bridging the gap between traditional herbal
medicine and modern drug delivery strategies. Further research can explore the broader applications
of such dendrimer complexes in drug delivery systems.
Determination of Spermidine and other 10 Biogenic Amines in Radix astragali (Huang qi) by HPLC-DAD with Precolumn Derivatization
Authors: Ni Sun Yan , Yun Ai , Rui Wang Jin , Ying He , Lu Zhang , Bin Tian Bin , Peng Tao Shun , Li Liu Jian , Ning Zhang 
Published: August 2024

Background:
Radix astragali (a Tonic-Qi traditional Chinese medicine) can enhance
cellular metabolism and increase the lifespan of cells. Spermidine can markedly extend the lifespan.
On the basis of these considerations, we assumed whether any relationship existed between
the anti-aging activity of Radix astragali and spermidine.

Methods:
In this research, spermidine and 10 other kinds of biogenic amines in Radix astragali
samples were identified and determined using high performance liquid chromatography-diode array
detector (HPLC-DAD) with precolumn derivatization. Biogenic amines were extracted with
hydrochloric acid, purified by n-butyl alcohol-dichloromethane extraction, and reacted with dansyl
chloride for derivatization before HPLC analysis.

Results:
The method had good repeatability and reproducibility for the quantitative determination
of biogenic amines in Radix astragali samples. Putrescine, spermidine, and spermine were detected
in 10 batches of Radix astragali samples. The total biogenic amines concentration was
48.09±2.22 mg/kg. Spermidine (22.84±2.59 mg/kg) was the highest amine in Radix astragali samples,
followed by putrescine and spermine. This is the first report that Radix astragali contains biogenic
amines, especially high content spermidine.

Conclusion:
The high content of spermidine might be the one reason for Radix astragali with Tonic-
Qi and anti-aging effect.
Vibrational Spectrophotometry: A Comprehensive Review on the Diagnosis of Gastric and Liver Cancer
Authors: Chandarana Chandni V. , Mithani Namira T. , Singh Diksha V. , Kikani Utkarsh B. 
Published: August 2024

Introduction:
Infrared and Raman spectroscopy have emerged as promising diagnostic
tools for gastric and liver cancer, offering significant advantages over traditional histology and biomarker-
based methods.

Methods:
These spectroscopic techniques provide rapid and highly specific molecular fingerprinting
with minimal sample preparation, enabling real-time diagnosis and preserving samples for further
analysis. The integration of nanoparticles, particularly in surface-enhanced Raman spectroscopy,
enhances the sensitivity and resolution of the method by amplifying signal strengths through
localized surface plasmon resonances. This advancement facilitates the detection of subtle molecular
changes associated with cancer, even at early stages.

Results:
Raman spectroscopy, a non-destructive technique, can differentiate between healthy and
malignant cells, aiding in the diagnosis of various gastric cancer forms, including adenocarcinoma
and gastrointestinal stromal tumors. Similarly, IR spectroscopy provides insights into the chemical
composition of tissues, detecting molecular changes associated with cancer. For liver cancer, including
hepatocellular carcinoma, these spectroscopic methods reveal biochemical alterations, facilitating
early detection and characterization of the disease. This review explores the application
of Raman and IR spectroscopy in diagnosing gastric and liver cancers, emphasizing their potential
to enhance diagnostic accuracy and improve patient outcomes by identifying molecular changes
linked to malignancies.

Conclusion:
Overall, the integration of nanoparticles into spectroscopic techniques holds significant
potential for improving the accuracy, speed, and efficacy of cancer diagnostics.
Warfarin Dose Maintenance Associated with CYP2C9*2 (rs1799853) and CYP2C9*3 (rs1057910) Gene Polymorphism in North Coastal Andhra Pradesh
Authors: Rangaraj Sivaraj , Ankani Bala Tripura Sundari 
Published: August 2024

Background
Deep Vein Thrombosis (DVT) is a high-risk condition that necessitates the use of oral anticoagulants for treatment. Warfarin, a common anticoagulant, exhibits varying levels of efficacy and toxicity among individuals. The CYP2C9 gene promoter polymorphism significantly influences the dosage requirements, a factor that remains underexplored in the contemporary Indian population.

Objectives
This study aimed to investigate the influence of CYP2C9 gene polymorphisms on warfarin dosage due to pharmacogenetic effects. Specifically, it examined the prevalence of the CYP2C9 polymorphic alleles *2 and *3 and their correlation with warfarin dosage in the South Indian Population (NCAP).

Methods
The study involved 96 warfarin-treated patients to determine the genotype frequency of common CYP2C9 polymorphisms. The genotypes of CYP2C92 and CYP2C93 polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A one-way analysis of variance (ANOVA) was conducted to ascertain dosage variation across genotypes.

Results
The study found that the frequencies of the two variations were 25.5% for CYP2C92 and 40.6% for CYP2C93. Patients with a homozygous wild-type genotype for CYP2C9 (*1/*1) required a daily warfarin dose of 4.07 ± 1.75 mg, significantly higher than the *1/*2, *1/*3 (2.93 ± 2.03 mg, p <0.0001) and *2/*2, *2/*3, and *3/*3 patients (1.54± 1.05 mg, p = 0.002). The study also revealed a distinct allelic frequency of CYP2C9 polymorphisms in the study population compared to other populations.

Conclusion
Given the relatively high prevalence of CYP2C9 polymorphisms in the studied population, practitioners should consider these findings to minimize the risk of bleeding when prescribing warfarin.
Green Synthesis of Nanoparticles for Forensic Applications: A Comprehensive Review on Latent Fingerprint Development
Authors: Sharma Anuj , Sharma Vaibhav , Kumari Poonam , Mavri Badal , Sankhla Mahipal Singh , Awasthi Kumud Kant , Gautam Archana , Sharma Tina , Kumar Rajeev 
Published: August 2024

Abstract:
Green nanoparticle synthesis has recently gained popularity due to its sustainability
and environmental friendliness. This technology employs natural resources
such as plants, fungi, bacteria, and algae to produce nanoparticles with beneficial
properties. This study aims to investigate the ecologically friendly production of nanoparticles
and their potential use in forensic investigation. Green nanoparticle synthesis
methods provide several advantages over standard chemical synthesis processes,
including less environmental impact, cheaper costs, and the lack of toxic compounds.
Nanoparticles have been successfully manufactured utilizing a wide range of
plant extracts, including those obtained from medicinal plants. Furthermore, nanoparticles
with enhanced properties have been developed employing microorganisms and
their metabolites. Nanoparticles made with environmentally benign technology have
shown significant promise in the realm of forensic study. These nanoparticles can be
employed in forensic analysis methods such as document authentication, DNA profiling,
and fingerprint identification. They are ideal candidates for boosting the sensitivity
and selectivity of forensic investigations because of their unique physicochemical
properties, which include a large surface area, variable size, and great stability.
Furthermore, to enable specialized detection and imaging of Latent fingerprints (forensic
evidence), green-synthesized nanoparticles can be functionalized with certain
ligands or biomolecules. This paper provides an overview of metal, metal oxide, and
fluorescent green nanoparticle manufacturing and their uses in forensic science as latent
fingerprint development.
DETERMINAN KEBAHAGIAAN PEREMPUAN BEKERJA DI INDONESIA: ANALISIS DATA INDONESIA FAMILY LIFE SURVEY
Authors: Nisrina Nursyiana  , Badriyah Nurul 
Published: August 2024

The purpose of this research is to analyze the determinants of happiness for working women in Indonesia. Using the cross-sectional data of Indonesia Family Life Survey (IFLS) wave 5, a number of 3,368 observations were selected using logistic model. This model was chosen because the dependent variables are categorical, and the normal assumption is in error distribution. This study finds that wage is still relevant to be used as a measure for welfare in Indonesia due to the absence of Easterlin Paradox in Indonesia. Higher wages enable the public to have more freedom in fulfilling their consumptive needs. Furthermore, non-economic factors such as education, age, and marital status influence the happiness of working women, while residence is not influential. Furthermore, “double burden” borne by married working women does not reduce their happiness because marriage helps them in financial security from difficult economic conditions, in addition to economic factors and specialization in their family that can increase income.
Pengaruh Viral Marketing dan Live Stream Terhadap Purchase Intention
Authors: Indrawan Luthfi Ananda , Pradana Bayu Ilham 
Published: August 2024

The existence of a trend called Racun Tiktok has an adverse effect in causing the impulsive and consumptive nature of social media users. In addition, TikTok has made shoppable live streams a new (and main) trend in online shopping at the TikTok Shop, because through this feature sellers and buyers can interact in two directions. This study aims to examine the effect of Viral marketing and Live stream on Purchase intentions for Skintific Products on TikTok. This research is a quantitative study with independent variables, namely Viral marketing (X1), Live stream (X2) and the dependent variable, namely Purchase intention (Y). The population studied is TikTok users in Indonesia who know Live TikTok and content that is currently viral from Skintific with a sample size of 134 responses. This study used a non-probability sampling technique with a purposive sampling method. Multiple linear analysis is used as a data analysis technique in this study. Based on the results of data analysis, all hypotheses can be accepted and it can be concluded that: 1) There is an influence between Viral marketing on Purchase intention. 2) There is an influence between Live stream on Purchase intention.

Abstrak
Adanya tren yang bernama Racun TikTok memberi dampak buruk dalam menimbulkan sifat impulsif dan konsumtif pengguna sosial media. Selain itu TikTok telah menjadikan shoppable live stream sebuah tren baru (dan utama) dalam belanja online di TikTok Shop, karena lewat fitur ini penjual dan pembeli bisa berinteraksi dua arah. Penelitian ini bertujuan untuk menguji pengaruh Viral marketing dan Live stream terhadap Purchase intention Pada Produk Skintific di TikTok. Penelitian ini merupakan penelitian kuantitatif dengan variabel independent yaitu Viral marketing (X1), Live stream (X2) dan variabel dependen yaitu Purchase intention (Y). Populasi yang diteliti merupakan pengguna TikTok di Indonesia yang mengetahui Live TikTok dan konten yang sedang viral dari Skintific dengan jumlah sampel sebesar 134 respon. Penelitian ini menggunakan teknik non-probability sampling dengan metode purposive sampling. Analisis linier berganda digunakan sebagai teknik analisis data pada penelitian ini. Berdasarkan hasil analisis data, semua hipotesis dapat diterima dan dapat disimpulkan bahwa: 1) Terdapat pengaruh antara Viral marketing terhadap Purchase intention. 2) Terdapat pengaruh antara Live stream terhadap Purchase intention.