bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biofunctional porous anodized titanium implants for enhanced bone regeneration
Authors: Shim In Kyong , Chung Hye Jin , Jung Mi Ra , Nam Seung Yeon , Lee Su Young , Lee Hyukjin , Heo Seong Joo , Lee Seung Jin 
Published: November 2013

AbstractEfficient osseointegration is a key factor in dental implants to reduce the total time‐course of therapy. Titanium implants with anodized surface gained much interest for their enhanced osseointegration. Anodized implant combined with bioactive drugs is an ideal candidate for enhance bone regeneration. Previously delivery of drugs from the metal implants has been attempted by utilizing a polymeric dip‐coating method. However, the entire surface coating with polymer can diminish the advantageous surface roughness of anodized implants and cause contact inhibition between bone and implant surface. In this study, fibroblast growth factor‐2 (FGF‐2) loaded poly(lactide‐co‐glycolide) nanoparticles were partially coated on anodized Ti discs by an electrospray deposition. Nanoparticle coated anodized discs maintained their native porous structure and provided a sustained release of FGF‐2 for more than 2 weeks with 40% initial burst. In vitro study confirmed the influence of polymeric nanoparticles and the release of growth factors from the Ti disc. Nanoparticle‐coated groups significantly enhanced cell spreading and differentiation. For in vivo evaluation, the anodized titanium implants were applied to rabbit tibia model. The osseointegration was estimated by bone to implant contact of best three consecutive threads at the border of the implant. The mean osteointegration value of FGF‐2 releasing implant groups (70.1%) was significantly higher than that of untreated implants (47.1%). We believe that the electrospray deposition technique is a particularly attractive approach for the coating of medical devices with porous surface to maintain their surface topography while allowing a sustained delivery of growth factors for bone regeneration. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3639–3648, 2014.
On the importance of crystallographic texture in the biocompatibility of titanium based substrate
Authors: Hoseini Majid , Bocher Philippe , Shahryari Arash , Azari Fereshteh , Szpunar Jerzy A. , Vali Hojatollah 
Published: November 2013

AbstractThe role of grain size and crystallographic orientation on the biocompatibility of commercially pure titanium was investigated. Samples, with significant differences in crystallographic texture and average grain size (from 0.4 to 40 µm) were produced by equal channel angular pressing (ECAP) and post deformation annealing. X‐ray diffraction and electron back scattered diffraction (EBSD) were used to evaluate differences in texture and microstructural characteristics. The titanium oxide film present on the surface of the samples was analyzed to determine the oxidation state of titanium and the chemical bonds between oxygen and titanium using X‐ray photoelectron spectroscopy (XPS). Biocompatibility experiments were conducted using MC3T3 preosteoblast cells. Cell attachment was found to be texture‐sensitive, where the number of attached cells was higher on the samples with higher number of (0002) planes exposed to the surface, regardless of the grain size. A relationship was also found between the titanium oxide species formed on the surface and the crystallographic texture underneath. The surface texture consisting of more densely packed basal planes promote the formation of Ti‐OH on the surface, which in turn, enhances the cell‐substrate interactions. These surface characteristics are deemed responsible for the observed difference in cell attachment behaviour of surfaces with different textures. Finally, it is inferred that texture, rather than the grain size, plays the major role in controlling the surface biocompatibility of biomedical devices fabricated from pure metallic titanium. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3631–3638, 2014.
Effects of Cu‐doped 45S5 bioactive glass on the lipid peroxidation‐associated growth of human osteoblast‐like cells in vitro
Authors: Milkovic Lidija , Hoppe Alexander , Detsch Rainer , Boccaccini Aldo R. , Zarkovic Neven 
Published: November 2013

AbstractBioactive glass (BG) is a highly attractive material, exhibiting both osteoinductive and osteoconductive properties, which is known to provide a growth enhancing surface for bone cells. Previous studies have shown that lipid peroxidation and in particular generation of 4‐hydroxynonenal (HNE) is involved in the growth of human osteoblast‐like cells, HOS, on BG. Copper (Cu), which is an essential cofactor of several enzymes as well as a proangiogenic and an antimicrobial agent, is known to induce lipid peroxidation. Therefore, the enrichment of BG with Cu could potentially have beneficial effects on the growth of the bone cells. In this study, we investigated the effects of copper‐doped 45S5 BG on the growth of HOS cells and the generation of HNE. Our results confirmed the association of HNE with the growth of HOS cells. The effects of added Cu were dose‐dependent. Specifically, low concentrations (i.e., 0.1% w/w) of Cu improved viability and enhanced HOS cell growth, whereas higher Cu concentrations [i.e., 2.5% and 1% (w/w)] were cytotoxic. The observed effects of Cu concentration on cell growth correlated with the level of HNE production. Therefore, Cu containing BG may represent a useful biomaterial for research and development studies of bone regeneration. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3556–3561, 2014.
Escalation from Fetish Burglaries to Sexual Violence: A Retrospective Case Study of Former Col., D. Russell Williams
Authors: Brankley Andrew E. , Goodwill Alasdair M. , Reale Kylie S. 
Published: November 2013

AbstractCriminal history narrative studies reveal an escalation in sexual offender behaviour from non‐contact to contact offending, with an ever‐increasing likelihood of sexual violence and homicide. In particular, researchers have found that sexual offenders often have a history of committing burglaries prior to contact offences. Accordingly, researchers have suggested that burglaries may be associated with an increased likelihood of future sexual offending, particularly when they have a sexual element to them. However, to date, there has been little quantitative research focusing on the mechanisms of escalation in sexual offences. This paper seeks to study factors associated with sexual offence escalation in terms of changes in offence seriousness and frequency. Specifically, case evidence was gleaned from a series of fetish burglaries and subsequent sexual assaults and murders committed by the former Canadian Colonel David Russell Williams (RW). Cluster analysis, chi‐square, ANOVA, and regression analyses were conducted on the crime scene information of RW's 82 cases of fetish burglary. Analyses revealed a significant escalation in the frequency and seriousness of RW's fetish burglary offences prior to committing acts of sexual violence and ultimately sexual homicide. Recommendations for future research predicting escalation of sexual offending by frequency and seriousness of offending behaviour are discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Analysis ofUKprecipitation extremes derived from Met Office gridded data
Authors: Simpson I. R. , Jones P. D. 
Published: November 2013

ABSTRACTIn Simpson and Jones (2012) we introduced new, homogenizedUKnational and regional rainfall series derived from 5 km gridded daily and monthly precipitation data. The monthly series were extended back to 1766 for monthly England and Wales (EW) precipitation, to 1873 for monthly values for each of the fiveEWsub‐regions, and to 1931 for daily values in all regions. Using data from those series, this paper provides analysis of how mean precipitation totals and extremes have changed over the respective periods. The results showed statistically significant upward trends in mean and extreme winter, spring and autumn precipitation for some Scottish regions, but trends over England and Wales were mostly insignificant, though England and Wales had a significant increase in winter precipitation over 1766–2011. The trend in summer precipitation over 1931–2011 has been statistically insignificant, though with a significant long‐term downward trend for England and Wales over 1766–2011. Prior observations of a trend towards drier summers and wetter winters have been complicated by a recent succession of wet summers and dry winters. Many of the observed changes in seasonal precipitation totals are most likely associated with changes in the North Atlantic Oscillation.
Promotion of normal healing of bone defects under estrogen deficiency by implantation of beta‐tricalcium phosphate composed of rod‐shaped particles
Authors: Tatsukawa Eri , Gonda Yoshinori , Kamitakahara Masanobu , Matsuura Masaaki , Ushijima Masaru , Shibata Yasuaki , Yonezawa Ikuho , Fujiwara Mutsunori , Ioku Koji , Ikeda Tohru 
Published: November 2013

ABSTRACTWe compared the healing of bone defects in ovariectomized rats implanted with beta‐tricalcium phosphate (β‐TCP) composed of rod‐shaped particles, which were prepared using the applied hydrothermal method (HTCP), and that of bone defects implanted with conventional β‐TCP composed of globular‐shaped particles (CTCP), which were prepared by normal sintering. Eight‐week‐old female Wistar rats were ovariectomized, and 2 weeks after the operation, 0.5‐ to 0.6‐mm diameter spherical granules of each ceramic were implanted in a bone defect created in the distal end of the femur. Four, 8, and 12 weeks after implantation, the amount of newly formed bone implanted with HTCP was significantly larger than that implanted with CTCP and was equivalent to that in non‐ovariectomized sham‐operated rats. Without implantation, spontaneous repair of the trabecular bone was barely observed. The physiological structure of the trabecular network was maintained in the region implanted with HTCP, but that in the region implanted with CTCP was severely destroyed. Gene expression microarray analysis revealed that the expression of genes involved in interferon signaling pathways was upregulated in osteoclasts cultured on HTCP compared with that cultured on CTCP. Our results suggest that the microstructure of β‐TCP affected the biological behavior of osteoclasts and regulated local bone metabolism. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:189–196, 2014.
Efficacy of endoscopic gastroduodenal stenting for gastric outlet obstruction due to unresectable advanced gastric cancer: A prospective multicenter study
Authors: Endo Shunji , Takiguchi Shuji , Miyazaki Yasuhiro , Nishikawa Kazuhiro , Imamura Hiroshi , Takachi Ko , Kimura Yutaka , Takeno Atsushi , Tamura Shigeyuki , Mori Masaki , Doki Yuichiro ,   on behalf of the CLINICAL STUDY GROUP OF OSAKA UNIVERSITY (CSGO), UPPER GI GROUP
Published: November 2013

AbstractBackground and ObjectivesGastroduodenal stents for gastric outlet obstruction due to unresectable advanced gastric cancer are increasingly used; however, their effects have not been fully evaluated.MethodsA multicenter prospective observational study was performed. Patients were eligible if they had stage IV gastric cancer with a gastric outlet obstruction scoring system (GOOSS) score of 0 (no oral intake) or 1 (liquids only). Self‐expandable metallic stents were delivered endoscopically. The effects of stents were evaluated.ResultsTwenty patients were enrolled and 18 were eligible (15 men, three women; median age, 70 years). Stent placement was successfully performed in all patients, with no complications. After stenting, a GOOSS score of 2 (soft solids only) or 3 (low‐residue or full diet) was achieved in 13 (72%) patients. An improvement in the GOOSS score by one or more points was obtained in 16 (94%) patients. The median duration of fasting and hospital stay was 3 (range, 0–9) days and 18 (6–168) days, respectively. Chemotherapy was performed after stenting in 13 (72%) patients.ConclusionsGastroduodenal stents are thought to be feasible, safe, and effective for gastric outlet obstruction due to unresectable advanced gastric cancer, with rapid clinical relief and a short hospital stay. J. Surg. Oncol. 2014 109:208–212. © 2013 Wiley Periodicals, Inc.
The Role of Military Social Support in Understanding the Relationship Between PTSD, Physical Health, and Healthcare Utilization in Women Veterans
Authors: Lehavot Keren , Der‐Martirosian Claudia , Simpson Tracy L. , Shipherd Jillian C. , Washington Donna L. 
Published: November 2013

Posttraumatic stress disorder (PTSD) is a significant predictor of both poorer physical health and increased health care utilization, whereas adequate social support is associated with better physical health and less health care utilization. However, research has not previously examined the simultaneous effects of PTSD and social support on health and health care utilization. This study examined both the independent and interactive effects of PTSD and a particular type of social support (postactive‐duty social support from military friends) on self‐reported physical health and number of Veterans Health Administration (VHA) visits in the last year. These relationships were examined in a representative, national sample of 3,524 women veterans who completed telephone interviews as part of the National Survey of Women Veterans in 2008–2009. Regression analyses were conducted using these cross‐sectional data to examine main effects of PTSD and military social support on physical health and VHA utilization and their interaction. Screening positive for PTSD was associated with poorer health (B = −3.19, SE = 1.47) and increased VHA utilization (B = 0.98, SE = 0.16), whereas greater military social support was associated with better health (B = 0.97, SE = 0.44) and less frequent VHA utilization (B = −0.15, SE = 0.05). Neither moderation model was significant, such that military social support behaved in a similar way regardless of PTSD status.
Health care service utilization among patients with chronic rhinosinusitis: A population‐based study
Authors: Chung Shiu‐Dong , Hung Shih‐Han , Lin Herng‐Ching , Lin Ching‐Chun 
Published: November 2013

Objectives/HypothesisPrevious studies showed that chronic rhinosinusitis (CRS) accounts for billions of dollars in healthcare resource utilization. However, all such study estimates of the economic burden of CRS were based on subpopulations in Western societies. This study aimed to investigate differences in the utilization of healthcare services between subjects with CRS and comparison subjects using Taiwan's National Health Insurance database.Study DesignA cross‐sectional study.MethodsIn total, 5,849 CRS subjects and 17,547 selected comparison subjects were included in this study. We evaluated healthcare resource utilization in a 1‐year period. Variables of healthcare resource utilization included the following: numbers of outpatient visits and inpatient days, and the mean costs of outpatient and inpatient treatment. We also divided healthcare resource utilization into ear, nose, and throat (ENT) and non‐ENT services.ResultsOn the utilization of ENT services, CRS subjects had significantly more outpatient visits (3.9 vs. 1.4, P < .001) and significantly higher outpatient costs (US$77.7 vs. US$19.4, P < .001) than comparison subjects. As for the use and costs of all healthcare services, CRS subjects had significantly more outpatient visits (27.9 vs. 18.3, P < .001) and significantly higher outpatient (US$953 vs. US$665, P < .001) and total (US$1319 vs. US$946, P < .001) costs than comparison subjects. Namely, on average, CRS subjects had 152% more outpatient visits and 139% higher total costs than comparison subjects.ConclusionsThis study found that subjects with CRS had significantly higher use of all healthcare services and costs than aged‐matched controls.Level of Evidence2c Laryngoscope, 124:1285–1289, 2014
End‐to‐side neurotization with different donor nerves for treating brachial plexus injury: An experimental study in a rat model
Authors: Yang Wengbo , Yang Jianyun , Yu Cong , Gu Yudong 
Published: November 2013

ABSTRACTIntroduction: End‐to‐side neurotization is currently used to treat brachial plexus injury, but it is not clear which donor nerve yields the best outcome. We performed experiments to determine the optimal donor nerve. Methods: A total of 66 male Sprague‐Dawley rats were assigned to 1 of 3 groups. Group A was the control group. In Group B, the phrenic nerve was used as the donor, while the ipsilateral C7 nerve root served as the donor in Group C. The epineurial window was used in end‐to‐side neurorrhaphy. Behavioral observations, histology, electrophysiology, and fluorescence retrotracing were performed postoperatively. Results: Fluorescence retrotracing confirmed nerve regeneration in both Groups B and C upon end‐to‐side neurotization. The outcome of Group B was superior to that of Group C. Conclusions: Use of the phrenic nerve as the donor nerve yielded a better outcome than use of the ipsilateral C7 nerve root. Muscle Nerve 50: 67–72, 2014
Prospective investigation of nimodipine for acute vocal fold paralysis
Authors: Rosen Clark A. , Smith Libby , Young Vyvy , Krishna Priya , Muldoon Matthew F. , Munin Michael C. 
Published: November 2013

ABSTRACTIntroduction: Nimodipine has been shown to be beneficial for recovery from acute vocal fold paralysis (AVFP) in an animal model. Methods: prospective, open‐label trial of patients with AVFP was performed using nimodipine. Consecutive patients were evaluated and offered nimodipine therapy. Results: Fifty‐three patients were considered for treatment with nimodipine. Thirteen did not qualify for inclusion, 5 were lost to follow‐up, and 7 had side effects requiring cessation of treatment. Thus 28 patients (30 paralyzed vocal folds) were analyzed. Eighteen of the paralyzed vocal folds experienced recovery of purposeful motion (60%). Historical controls and laryngeal electromyography meta‐analysis suggest no more than a 20% recovery rate from AVFP. Conclusions: This open label study using nimodipine for treatment of AVFP demonstrates tripling of the recovery rate of vocal fold motion compared with historical controls. Further study in a randomized, controlled manner is warranted. Muscle Nerve 50: 114–118, 2014
Helium: Überfluss im Weltall, Mangel auf der Erde
Authors: Ehrensberger Christian 
Published: November 2013

AbstractHelium ist im Universum das zweithäufigste Element, doch auf der Erde wird es knapp. Das verbreitet Unruhe unter Analysechemikern, Teilchenphysikern und Radiologen. Die Lösung des Problems lautet: Langfristig mehr Helium fördern und kurzfristig mit Verfahrensänderungen gegensteuern.
Zulassungspflicht unter Reach
Authors: Geldsetzer Felix 
Published: November 2013

AbstractDas Zulassungsverfahren im europäischen Chemikalienrecht soll “besonders besorgniserregende Stoffe” aus dem Markt entfernen. Ist ein solcher Stoff für ein Unternehmen unverzichtbar, kann es eine Ausnahmegenehmigung bei der Europäischen Kommission beantragen.
Komplexe Proben und zweidimensionale Trennmethoden
Authors: von Trotha Alexandra , Li Duxin , Schmitz Oliver J. 
Published: November 2013

AbstractPflanzliche Extrakte, wie sie die traditionelle chinesische Medizin einsetzt, enthalten eine Unmenge an Substanzen. Einzelne Wirkstoffe aus diesen Mischungen zu identifizieren, erfordert hochauflösende Trenn‐ und Detektionsmethoden. Allerdings stoßen hier auch sie an ihre Grenzen.
Exercise training in childhood cancer survivors with subclinical cardiomyopathy who were treated with anthracyclines
Authors: Smith Webb A. , Ness Kirsten K. , Joshi Vijaya , Hudson Melissa M. , Robison Leslie L. , Green Daniel M. 
Published: November 2013

AbstractChildhood cancer survivors (CCS) treated with anthracyclines are at risk for cardiomyopathy. This case series evaluated the response of anthracycline exposed CCS with subclinical cardiomyopathy to aerobic and strength training. Body composition, strength and cardiopulmonary fitness were evaluated before and after the 12‐week intervention. All equipment and materials were provided to five 10+ year CCS (3 males, mean age 38.0 ± 3.3 years) for a guideline‐based home exercise program. All five completed the study with no adverse events. Compliance with exercise was 86%. These results suggest that exercise training may improve exercise capacity of CCS with subclinical cardiomyopathy. Pediatr Blood Cancer 2014;61:942–945. © 2013 Wiley Periodicals, Inc.
Rural‐Urban Migration and Domestic Land Grabbing in China
Authors: Siciliano Giuseppina 
Published: November 2013

ABSTRACTDomestic land grabbing is defined as the process of land expropriation and displacement put in place by governments within their country borders to supposedly enhance development. Although development‐induced displacement occurs all over the world, China is responsible for a large fraction of such type of displacement and resettlement projects. Urban sprawl and land commodification for food security and agricultural modernization are the main consequences of domestic land grabbing in the country. Albeit the attention towards the implications of urbanization and resettlement projects on social stability of China has recently increased, studies which try to identify their main drivers, as well as to look at the impacts, trade‐offs and migrant views, are still rare. Drawing on a case study from a rural island in east China, this paper analyses resettlement projects in relation to (i) land tenure rights and compensation measures, (ii) rural workers livelihood and the hukou registration system, and (iii) environmental degradation. Results reveal that landless people are facing the risk of unemployment, food self‐sufficiency problems and the mismanagement of resettlements. Additionally, such projects bring about a higher risk of environmental degradation in rural areas. Copyright © 2013 John Wiley & Sons, Ltd.
Should I Stay or Should I Go? An Analysis of the Determinants of Intra‐European Student Mobility
Authors: Van Mol Christof , Timmerman Christiane 
Published: November 2013

ABSTRACTIn recent years, organised student mobility within the European space has increasingly caught the interest of scholarly researchers. As the focus of most research projects has been on the outcome of mobility programmes, studies into the determinants of credit student mobility remain rather focused on individual decision‐making. However, in order to gain a more profound understanding of how students' motivations to participate in international mobility programmes are shaped, we have to go a step further. Therefore, in this paper, we present a study into the determinants of intra‐European student mobility, conducted in Austria, Belgium, Italy, Norway, Poland, and UK, taking into account students' personal background and motivations. The results are based on an online survey (n = 5654) and in‐depth interviews and focus groups with non‐mobile as well as ex‐mobile students (n = 71). The results show that mobility decisions are socially and biographically embedded. Moreover, we provide evidence that the decision to spend a study period abroad cannot be fully understood without taking into consideration the macroeconomic context. Copyright © 2013 John Wiley & Sons, Ltd.