bluuebunny/crossref_metadata_2025_split huggingface dataset:
Key laboratory variations in severe trauma, different natural evolution according to patient phenotype
Authors: Morales Adrián Marcos , Mendoza Jesús Abelardo Barea , Fernández Marcos Valiente , Fuentes Carlos García , Boyero Fernando Calvo , Cueto-Felgueroso Cecilia , Gutiérrez Judith Gutiérrez , Moya Francisco de Paula Delgado , Reche Carolina Mudarra , Aznárez Susana Bermejo , Fernández Mario Chico 
Published: August 2024

Abstract

Purpose
This study aimed to describe the natural evolution of conventional laboratory parameters in four severe trauma patient phenotypes.
Methods
An observational analytical study in an intensive care unit (ICU). Patients with severe trauma were included, defined as those having at least one affected anatomical region with an Abbreviated Injury Scale (AIS) of ≥ 3 points. After classification into four relevant groups according to the hemodynamic (HD) status and the presence or absence of major traumatic brain injury (TBI with AIS ≥ 3), evolution of laboratory parameters was described and plotted in a timeline going from patient ICU arrival to time points 24, 48, 72 and 96 hours later. Contrast hypothesis tests were performed for data at the 0 and 24 hour time points.
Results
A total of 1626 severe trauma patients were included, 80% in the two stable HD groups. Most laboratory differences were found between stable and unstable HD groups, such as lower hemoglobin and platelet count on arrival and after 24 hours, higher lactate and metabolic acidosis from arrival to 24 hours in the most severely ill, low ionized calcium up until 24 hours, and alteration of coagulation only in the most severe subgroup. Differences were also found in patients with major TBI compared with those without, especially in the leukocyte formula. A 24 hours peak in neutrophil-to-lymphocyte ratio was notable in all patients with major TBI, being highest in patients with both unstable HD and major TBI.
Conclusion
The natural evolution of laboratory parameters differs according to patient phenotype. It completes the picture of hemodynamic status and it also gives insight into the presence of major TBI both in hemodynamically stable or unstable contexts.
Novel mutation of NOTCH3 gene in a Chinese Patient with CADASIL: A case report
Authors: gao xiang , Wang Jie , Hou Lijing , Lin Jixiang , Zhang Xiaoyu , Zhang Xiao , Liu Xiaomin 
Published: August 2024

Abstract

Introduction:
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic cerebral small-vessel disease characterized by migraine, recurrent ischemic strokes, psychiatric disorder, and progressive cognitive decline. CADASIL is a cerebrovascular disease closely related to the NOTCH3 gene and to date, over 300 mutations in this gene have been reported. Herein, we describe a patient with CADASIL carrying a novel NOTCH3 frameshift mutation in exon 28. We present the results of a detailed clinical work-up and, in the light of the published literature, discuss the pathophysiological relevance of this genetic finding.
Case presentation:
A 56-year-old woman was hospitalized due to migraines and recurrent cerebral infarction. Brain magnetic resonance imaging (MRI) showed multiple ischemic infarcts, microbleed lesions and demyelination of white matter around the bilateral ventricles. Mutation analysis identified a novel frameshift mutation, c.5171_5172delCA, p. (Thr1724fs17), in the NOTCH3 gene in a heterozygous state in this patient. Thus, this patient was diagnosed with genetically confirmed CADASIL.
Conclusions
We report a novel mutation, c.5171_5172delCA, p. (Thr1724fs17), in the NOTCH3 gene in a Chinese patient with CADASIL. This report broadens the NOTCH3 gene mutation spectrum.
Development of a patient-reported ONCOlogical-ROUTinE-Screening (ONCO-ROUTES) procedure and its digital implementation at the University Cancer Center Regensburg
Authors: Maurer Julia , Saibold Anna , Gerl Katharina , Koller Michael , Koelbl Oliver , Pukrop Tobias , Windschuettl Sandra , Einhell Sabine , Herrmann-Johns Anne , Raptis Georgios , Mueller Karolina 
Published: August 2024

Abstract

Purpose
The evaluation of treatment success and progression in oncology patient-reported outcomes (PROs) is playing an increasingly important role. Meanwhile, PROs are a component of the certification requirements of the German Cancer Society for oncology centers. PROs are used to provide supportive therapy. At the University Hospital Regensburg (UKR), a digital ONCOlogical-ROUTinE-Screening (ONCO-ROUTES) procedure was developed in order to assess the need for supportive therapy in a standardized way and to provide patients with supportive interventions tailored to their needs.
Methods
On the basis of already established processes and current requirements, the development of ONCO-ROUTES was supported by experts in focus groups and interviews, and digitalization was carried out in connection with the IT infrastructure.
Results
A Needs-based, Quality-of-life (QoL) and Symptoms Screening (NQS2) tool already established in the routine at the UKR was further developed into ONCO-ROUTES, which is made up of the domains therapy phase, nutrition, tobacco use, alcohol use, quality of life, general condition/functional status, physical activity, psychooncology, social services, and further support needs. By linking the digitized questionnaire to the hospital information system, the results are available for immediate use in routine operations and thus for the referral of patients for further supportive therapy.
Conclusion
Especially digital PROs enable a wide range of clinical applications in the context of oncology centers. ONCO-ROUTES is designed to include patients in their treatment and to provide supportive interdisciplinary treatment that is tailored to their needs.
Effects of temperature and food availability on feeding behaviour and metabolism in the sea cucumber Cucumaria frondosa.
Authors: Kabanova Ekaterina , Filgueira Ramón 
Published: August 2024

Abstract

Cucumaria frondosa is the largest and most abundant species of sea cucumber in the North Atlantic and Arctic oceans. C. frondosa are commercially exploited in Maine and Atlantic Canada, and sustainable stock management requires addressing knowledge gaps in their ecophysiology and bioenergetics. While temperature is commonly assumed to be the principal factor affecting the metabolic rates of aquatic ectotherms, food availability determines the feeding ecology and ultimately, growth rates of suspension feeders such as C. frondosa. Effects of temperature and food availability on individual feeding rates, metabolism, and population-level feeding activity were investigated in C. frondosa collected in May-July of 2023 from Nova Scotia, Canada (44°40’41.2’’ N 63°36’30.4’’ W). In the first experiment, temperature was increased from 5°C to 16°C by 1°C every 3 days. Maximum tentacle insertion rates (TIR; a proxy for food intake) and cloacal opening rates (COR; a proxy for respiration) increased with temperature while the total proportion of feeding individuals generally decreased. Above 12°C, novel abnormal behaviors – rhythmic openings of the mouth and incomplete TIR – emerged, and became increasingly common at higher temperatures, suggesting thermal stress. In the second experiment, phytoplankton concentration was increased from 2,000 cells ml− 1 to 50,000 cells ml− 1 by 10,000 cells ml− 1 every 3 days. TIR increased until ~ 30,000 cells ml− 1, then plateaued. The proportion of feeding individuals increased with food availability, with all individuals feeding at 40,000 cells ml− 1. These findings provide insight into the physiological performance of C. frondosa under different environmental conditions and can help inform fisheries management.
Phytochemical mediated Synthesis and Characterization of Copper Oxide Nanoparticles and Its Oxygen Reduction Reaction Activity
Authors: Yadav Shyam Raj , Prakash Jai , Kumari Manisha , Rinki Kumari , Sonkar Piyush Kumar , Kumar Narvadeshwar 
Published: August 2024

Abstract

A successful preparation of copper oxide nanoparticles (CuONPs) by using leaves extract (PE) of plant Combretum roxburghii Spreng. (C. roxburghii Spreng.) and its application towards oxygen reduction reaction (ORR) are reported here. The synthesized CuONPs were characterized by ultraviolet-visible (UV-vis) spectroscopy, Fourier transforms infrared (FTIR) spectroscopy, X‑ray diffraction (XRD), Scanning electron microscope (SEM), high reosolution-transmission electron microscopy (HR-TEM), Inductively coupled plasma atomic emission spectroscopy (ICP-AES) and thermogravimetric analysis (TGA). ICP-AES and SEM mapping confirmed the presence of Cu in synthesised NPs. The size of synthesized CuONPs had been found in the range of 2.06 to 6.20 nm with distorted spherical shape by HR-TEM. Both PE and CuONPs were coated on glassy carbon (GC) electrode to form modified electrodes, designated as GC/PE and GC/CuONPs respectively. These GC/PE and GC/CuONPs electrodes were subjected to cyclic voltammetry (CV) characterizations. It was found that GC/CuONPs displays good electrocatalytic activity for ORR. GC/CuONPs also exhibits outstanding operational stability up to 1000 CV cycles.
We want another job: A multi-country qualitative study on the self-reported health, social, and economic needs of female sex workers with children.
Authors: Weerasinghe Swarna D.S. , Fitzgerald Meghan , Macias-Konstantopoulos Wendy L. , Perttu Emily , Willis Brian 
Published: August 2024

Abstract

Background
The mothering role of female sex workers, as the sole provider, in low- and middle-income countries (LMIC) is quite challenging and most of them turn into sex work to meet the basic needs of the family. Efforts to address their unique needs across the spectrum of matriarchy and often stigmatized occupational identity within the context of LMIC requires research-based evidence. The community-centric health and social care needs of 2657 female sex worker mothers (FSWM) in eight LMICs (Angola, Brazil, DRC, India, Indonesia, Kenya, Nigeria, and South Africa) were explored.
Methods
The data came from a community-participatory mixed method study conducted among 2657 women in 165 group discussions. The two-stage feminist ethics of care framework was applied to FSWM narratives to guide thematic analysis. In the first stage we focused on how sex work serves as means of survival and the second stage guided the duty to sacrifice for their children.
Results
Four major themes were identified using an inductive coding qualitative approach: assistance with alternative sources of income; healthcare needs; education needs for children; and equitable social respect/legal rights. Application of the feminist ethics of care framework, at the intersection of sex work and motherhood, revealed the leading priority for mothers in sex work is alternative sources of income. The findings reveled that engagement in sex work is for the survival of children and stigma and discrimination impede access to healthcare for female sex workers mothers and their children.
Conclusion
From a theoretical standpoint, our findings align with the two components of the feminist ethics of care; fulfilling self-care first and then making self-sacrifice in providing a nurturing environment for children. The most expressed need was support for alternative sources of income, to transition out of sex work, realizing the work-related threats and dangers for them and their children. This study suggests that legal and HIV protection may not be their highest priority. Local organizations should include the FSWM community as equal partners in addressing unmet health, social and economic needs to ensure that welfare program implementations are responsive to and prioritize the self-reported needs of FSWM.
Growth of trimetallic CeFeNi-MOF-74 on nickel foam as a bifunctional electrocatalyst for water splitting
Authors: Zhang Jun , Long Tao , Liu Yangwen , Zhong Zilang , Zhang Yang , Chen XuChang , Li Guanghuan 
Published: August 2024

Abstract

In order to facilitate the industrial synthesis of hydrogen from electrolytic water on a wide scale, high-performance non-precious metal electrocatalysts that can substitute precious metal electrocatalysts must be developed. This paper reports a trimetallic CeFeNi-MOF-74 electrocatalyst grown on nickel foam (NF) by solvothermal method. The introduction of trimetallics gives the metal-organic frameworks (MOFs) materials synergistic and complementary properties, resulting in better catalytic properties of the materials. Tuning the electronic structure of materials to optimize electrocatalytic performance by modulating metal ratios. It was found that the prepared Ce0.9FeNi-MOF-74 exhibited excellent electrocatalytic activity and stability in the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). In 1 M KOH, the overpotential is only 262 mV for HER at a current density of 100 mA cm− 2 and 257 mV for OER at a current density of 100 mA cm− 2. For overall water splitting (OWS), a low voltage of only 1.68 V is required to achieve a 10 mA cm− 2 current density. The excellent catalytic performance of Ce0.9FeNi-MOF-74 exceeds that of many commercial catalysts. This study provides new insights into the synthesis of high-performance and stable MOF electrocatalysts.
Study of variation in physical and thermomechanical properties of Kevlar epoxy composite with bi-filler (NiCo2O 4 nanoparticles and wood sawdust) reinforcement
Authors: Balasubramanian Nivedha , Mahalingam Ashok 
Published: August 2024

Abstract

The advancement in the development of hybrid filler-reinforced composites widens its usability in structural applications as a replacement for conventional materials. Filler incorporation into the composites imparts out-of-the-ordinary enrichment to material properties and plays a significant role in enhancing its physical, mechanical, and thermal characteristics. In this work, Kevlar epoxy composites are fabricated with bi-filler reinforcement viz, wood sawdust (natural filler – fixed as 5 wt%) and NiCo2O4 nanoparticles (synthetic filler – varying as 0.5, 1, 1.5, 2 wt%) using open-mold hand layup technique. Sol-gel synthesized NiCo2O4 nanoparticles are characterized with XRD and FESEM to ensure their purity and spherical morphology. Among filler-loaded composites, 1.5 wt% of NiCo2O4 nanoparticles reinforced Kevlar epoxy composite shows a superior tensile strength of 61.9 MPa. High thermal stability is observed for 1.5 wt% of NiCo2O4 nanoparticles/ 5 wt% wood sawdust reinforced Kevlar epoxy composite, wherein, it can be potentially efficient for thermal applications. Physical properties seem to be better for 1 wt% of NiCo2O4 nanoparticle reinforcement that prevents the composite from microcracking due to low wettability.
Analysis and Interpretation the Effect of General Anisotropy on 3-D Marine CSEM Response Based on a Goal-oriented Adaptive FE Method
Authors: li jiankai , Cai Ji , Liu Ying , Liu Lihua , Huang Ling , Gao Jingyu , Liu Xiao , Fang Guangyou 
Published: August 2024

Abstract

The marine controlled-source electromagnetic (CSEM) method offers a range of applications in marine geophysics, including mapping hydrocarbon reservoirs, studying seafloor geology, identifying potential mineral deposits, and investigating hydrate occurrences. Nevertheless, the interpretation of marine CSEM data becomes challenging when complex anisotropy is present. Therefore, we extend the scope of numerical simulations of 3-D marine CSEM responses from a specific case of dipping anisotropy to general anisiotropy based on a goal-oriented adaptive finite element (FE) method. We verify the upgraded argorithm using a 1-D anisotropic layered model with quasi-analytical solutions, and then apply the algorithm to compute marine CSEM responses over a set of 3-D anisotropic models. The behavior of the responses is explained by visualizing the flow of electromagnetic energy within the anisotropic conductivity structures using the Poynting vector, which helps explain how the energy propagates and interacts with the anisotropic media, providing insights into the observed response patterns. The numerical results clearly demonstrate that both the dipping and azimuthal anisotropy in the sediment have considerable impacts on marine CSEM responses, but their effects follow different patterns and highly dependent on the orientation of the electric dipole source utilized. However, the influence of the anisotropic reservoir can hardly be observed. This study emphasizes the significance of incorporating anisotropy into the interpretation of marine CSEM surveys. It contributes to the understanding of the impacts of general anisotropy on marine CSEM responses and provides a valuable approach for accurately modeling and interpreting marine CSEM data in the presence of anisotropic conductivity.
Enzymatic synthesis of structured DHA phospholipids in a solvent- free medium with potential effects in the treatment of neurodegenerative diseases
Authors: García-Quinto Ernestina , Guisan Jose M. , Fernandez-Lorente Gloria 
Published: August 2024

Abstract

Phospholipids containing docosahexaenoic acid (DHA) esterified at the sn-2 position of glycerol could contribute to the prevention of neurodegenerative diseases such as Alzheimer's. Optimizing the synthesis bioprocesses for these structured DHA lipids is essential to ensure their bioavailability, allowing them to cross the blood-brain barrier and be efficiently incorporated into neuronal membranes. Lipases and phospholipases are gaining attention due to their role as biocatalysts in selectively modifying and producing structured lipids. In particular, enzymatic processes in solvent-free media are highly valued for their ecological, economic, and technological benefits. Immobilization and post-immobilization techniques are indispensable for obtaining highly stable biocatalysts in solvent-free media. The immobilized derivative of phospholipase Quara® LowP (QlowP-C18) is the optimal catalyst for synthesizing di-substituted DHA phospholipids, achieving a yield of 58%. The post-immobilization technique increases the stability of QlowP-C18 threefold, allowing it to be reused for up to five reaction cycles at 40ºC.
Assessment of Rare Earth elements in Asejire Lake, Nigeria
Authors: Adeboye Ayodele Christianah , Omotoso Oladele Ajiboro , Afolabi Olukayode Adegoke , Akinwole Isreal Oluwatimileyin , Elabor Isa 
Published: August 2024

Abstract

This study evaluated the distribution of rare earth elements (REEs) in the Asejire Reservoir, Southwest Nigeria, a region lacking comprehensive REE assessment despite the growing concern over REE contamination due to industrial and technological advancements. Using inductively coupled plasma-mass spectrometry (ICP-MS), we analyzed 12 water samples to determine their REE concentrations. The total REE (∑REE) concentrations ranged from 10.35 to 13.44 µg/L. Cerium (Ce/Ce*), Europium (Eu/Eu*) and Gadolinium (Gd/Gd*) anomalies were 0.19–0.24, 0.18–0.24 and 0.94–1.23, respectively, indicating strong negative anomalies for Ce/Ce* and Eu/Eu*, while Gd/Gd* showed a slight positive anomaly. These results suggest that the water in the study area is relatively pristine with respect to REEs. The enrichment factor (EF) analysis showed slight enrichment/contamination (1 ≤ EF < 2) for light REEs (LREEs) and middle REEs (MREEs), while heavy REEs (HREEs) mostly showed no enrichment (EF < 1). Notably, most samples had Lanthanum (La) and Cerium (Ce) concentrations above the indicative admissible drinking water concentration (iAC = 2.0 µg/L), implying potential adverse effects from ingestion. Principal component analysis (PCA) revealed that 71.2% of the variability is accounted for by the first two principal components (PC): PC1 (61.22%) is attributed to natural inputs of REEs, while PC2 (10.51%) suggests some anthropogenic input. In conclusion, this study reveals that the Asejire Reservoir is slightly impacted by anthropogenic influences and local authorities should implement appropriate measures to prevent further deterioration.
Analysis of individual plants reveals the genetic control for local adaptation in European maize landraces
Authors: Aiyesa Leke , Beissinger Timothy , Scholten Stefan , Link Wolfgang , Zumbach Birgit 
Published: August 2024

Abstract

European maize landraces encompass a large amount of genetic diversity, allowing them to be well-adapted to their local environments. This diversity can be exploited to improve the fitness of elite material in the face of a changing climate. We characterized the genetic diversity of 333 individual plants from 40 European maize landrace populations (EMLPs). We identified five genetic groups that mirrored the proximities of their geographical origins. Fixation indices (Fst) showed moderate differentiation among genetic groups (0.034 to 0.093). More than half of the genetic variance was observed to be partitioned among individuals. Nucleotide diversity of EMLPs decreased significantly as latitude increased (from 0.16 to 0.04), suggesting serial founder events during maize expansion in Europe. GWAS with latitude, longitude, and elevation as response variables identified 28, 347, and 68 significant SNP positions, respectively. We pinpointed significant SNPs near dwarf8, tb1, ZCN7, ZCN8, and ZmMADS69, and identified 137 candidate genes with ontology terms indicative of local adaptation in maize, regulating the adaptation to diverse abiotic and biotic environmental stresses. This study suggests a quick and cost-efficient approach to identifying genes involved in local adaptation without requiring field data. The EMLPs used in this study have been assembled to serve as a continuing resource of genetic diversity for further research aimed at improving agronomically relevant adaptation traits.
Contrasting effects of symbiont inoculation on soil microbiota functionalities in a rehabilitation program of salt-affected lands
Authors: Djighaly Pape Ibrahima , Diagne Nathalie , Tournier Estelle , Ngom Mariama , Cissoko Maimouna , Tisseyre Pierre , Ngom Daouda , Hocher Valérie , Svistoonoff Sergio , Sanguin Hervé 
Published: August 2024

Abstract

Soil salinization has become a major global ecosystem sustainability issue. In Senegal, promising ecosystem restoration of salt-affected lands has been reached by the implementation of ecological engineering strategies based on beneficial associations between Casuarina species and salt-tolerant symbiotic microorganisms. However, the extent of impacts of symbiont inoculants on the native soil microbiota, and consequently soil functioning is fragmentary. The current study aimed at evaluating the changes in the native soil microbiota associated with the use of a symbiont inoculant in mixed Casuarinaceae plantations in salt-affected lands. The symbiont inoculation lead to a decrease of soil fungal diversity, but not bacteria. However, the whole soil microbiota structure was impacted by symbiont inoculation, as by salinity and Casuarina species. Casuarina species also impacted the diversity of dominant taxa constituting soil microbiota, but only salinity affected bacterial diversity. Important modifications of soil microbiota functionalities were revealed, notably a decrease of bacterial pathogens related to symbiont inoculation and increased abundance of fungal pathogens with salinity. Soil nutrient cycling was also impacted by symbiont inoculation, mostly micronutrient cycling and N fixation, but salinity and Casuarina species were the main factors affecting N cycling in soil.