bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental disorders and distress: Associations with demographics, remoteness and socioeconomic deprivation of area of residence across Australia
Authors: Enticott Joanne C , Meadows Graham N , Shawyer Frances , Inder Brett , Patten Scott 
Published: November 2015

Objectives: Australian policy-making needs better information on socio-geographical associations with needs for mental health care. We explored two national surveys for information on disparities in rates of mental disorders and psychological distress. Methods: Secondary data analysis using the 2011/2012 National Health Survey and 2007 National Survey of Mental Health and Wellbeing. Key data were the Kessler 10 scores in adults in the National Health Survey ( n = 12,332) and the National Survey of Mental Health and Wellbeing ( n = 6558) and interview-assessed disorder rates in the National Survey of Mental Health and Wellbeing. Estimation of prevalence of distress and disorders for sub-populations defined by geographic and socioeconomic status of area was followed by investigation of area effects adjusting for age and gender. Results: Overall, approximately one person in 10 reported recent psychological distress at high/very-high level, this finding varying more than twofold depending on socioeconomic status of area with 16.1%, 13.3%, 12.0%, 8.4% and 6.9% affected in the most to least disadvantaged quintiles, respectively, across Australia in 2011/2012. In the most disadvantaged quintile, the percentage (24.4%) with mental disorders was 50% higher than that in the least disadvantaged quintile (16.9%) in 2007, so this trend was less strong than for Kessler10 distress. Conclusion: These results suggest that disparities in mental health status in Australia based on socioeconomic characteristics of area are substantial and persisting. Whether considering 1-year mental disorders or 30-day psychological distress, these occur more commonly in areas with socioeconomic disadvantage. The association is stronger for Kessler10 scores suggesting that Kessler10 scores behaved more like a complex composite indicator of the presence of mental and subthreshold disorders, inadequate treatment and other responses to stressors linked to socioeconomic disadvantage. To reduce the observed disparities, what might be characterised as a ‘Whole of Government’ approach is needed, addressing elements of socioeconomic disadvantage and the demonstrable and significant inequities in treatment provision.
Performance prediction of a new integrated central cooling plant for energy efficiency and comfort enhancement
Authors: Vakiloroaya Vahid , Samali Bijan , Eager David 
Published: November 2015

The effective design of an energy efficient heating, ventilation and air conditioning system is reliant on multiple components. Among others, the air-handling unit cooling coil and its ability to perform efficiently directly influences heating, ventilation and air conditioning system performance. This paper investigates the energy and thermal performance of a water-cooled central cooling plant when combined with a direct evaporative cooling system located between the cooling tower and cooling coil of the air-handling unit. The evaporative cooler uses the water made by cooling tower to reduce the temperature of the 100% ambient air. The cooled air then passes through the cooling coil. This paper will demonstrate a series of mathematical models of the system components and validate them against experimental results. For this purpose, the central cooling plant is extensively equipped with a number of sensors and instrumentation devices for experimentation and data collection. The influence of the evaporative cooler on the energy saving potential and thermal comfort of the central cooling plant is evaluated. The advantages of this proposed hybrid system rests with the fact that the refrigeration effect of the chiller’s evaporator is decreased, which causes reduction of compressor power consumption. Results show that the hybrid system can provide average monthly energy savings between 11% and 24%, while enhancing the comfort level inside the building. Practical application: With traditional heating, ventilation and air conditioning systems contributing to 40% of a building’s overall energy consumption, the public’s increasing reliance on them as a necessity rather than a luxury is an issue in urgent need of attention. This together with a growing demand for cost-effective infrastructure and appliances has necessitated new installations and major retrofits in occupied buildings to achieve energy efficiency and environmental sustainability. The aim of this paper is to present a new integrated heating, ventilation and air conditioning system to meet these requirements without compromising comfort and indoor air quality.
Chemotherapy regimen checks performed by pharmacists contribute to safe administration of chemotherapy
Authors: Suzuki Shinya , Chan Alexandre , Nomura Hisanaga , Johnson Philip E , Endo Kazushi , Saito Shinichiro 
Published: November 2015

Background Computerized provider order entry (CPOE) has been developed and implemented within cancer center hospitals nationwide in Japan. To ensure that high-quality services are routinely provided by oncology pharmacists, this study was designed to evaluate the interventions through reviewing the orders that are generated by CPOE. Methods The objective of this retrospective chart review was to evaluate how pharmacists contributed to safe cancer treatment using paper-based pharmacy records. Data were collected from a total of 35,062 chemotherapy regimens for 18,515 outpatients between January and December 2013. Results Of these 35,062 chemotherapy regimens, the rate of pharmacists’ interventions was 1.1% ( n = 408). Among them, 53.1% (217/408) of the chemotherapy prescriptions were modified due to pharmacist interventions. The reasons for interventions included “changes in the chemotherapy regimen were unclear” in 49.5%, “physicians’ prescription errors” (22.0%), “pharmacist suggestions to improve chemotherapy” (15.1%), and “finding differences between physicians’ chemotherapy records and their chemotherapy prescriptions” (13.2%). The top three reasons for the 217 prescription modifications due to pharmacist interventions were “finding prescription errors” (34.5%), “reasons for change in the chemotherapy regimen were unclear” (32.7%), and “finding differences between physicians’ chemotherapy records and their chemotherapy prescriptions” (28.5%). Conclusion The computer could not evaluate chemotherapy protocols or adjust doses of anticancer medicines according to patients’ conditions. Therefore, oncology pharmacists should continue to ensure safe and appropriate administration of cancer chemotherapy.
Nutritional management in critically ill trauma patients is challenging
Authors: Service Emma , Anwar Fahim 
Published: November 2015

Background The physiological stress following major trauma in critical illness leads to rapid malnutrition and provision of optimal nutritional support in these circumstances can be challenging. Case report We present a complex trauma case where relatively aggressive nutritional support failed to minimise weight loss. Conclusion Nutritional support plays an integral role in the care of critically ill major trauma patients and needs to be continuously monitored in the subacute and rehabilitation phase.
Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions
Authors: Wang Juan , Hao Jie , Bai Donghui , Gu Qi , Han Weifang , Wang Lei , Tan Yuanqing , Li Xia , Xue Ke , Han Pencheng , Liu Zhengxin , Jia Yundan , Wu Jun , Liu Lei , Wang Liu , Li Wei , Liu Zhonghua , Zhou Qi 
Published: November 2015

Abstract
Introduction
Human induced pluripotent stem cells (hiPSCs) are considered as one of the most promising seed cell sources in regenerative medicine. Now hiPSC-based clinical trials are underway. To ensure clinical safety, cells used in clinical trials or therapies should be generated under GMP conditions, and with Xeno-free culture media to avoid possible side effects like immune rejection that induced by the Xeno reagents. However, up to now there are no reports for hiPSC lines developed completely under GMP conditions using Xeno-free reagents.

Methods
Clinical-grade human foreskin fibroblast (HFF) cells used as feeder cells and parental cells of the clinical-grade hiPSCs were isolated from human foreskin tissues and cultured in Xeno-free media. Clinical-grade hiPSCs were derived by integration-free Sendai virus-based reprogramming kit in Xeno-free pluriton™ reprogramming medium or X medium. Neural cells and cardiomyocytes differentiation were conducted following a series of spatial and temporal specific signals induction according to the corresponding lineage development signals. Biological safety evaluation of the clinical-grade HFF cells and hiPSCs were conducted following the guidance of the “Pharmacopoeia of the People's Republic of China, Edition 2010, Volume III”.

Results
We have successfully derived several integration-free clinical-grade hiPSC lines under GMP-controlled conditions and with Xeno-free reagents culture media in line with the current guidance of international and national evaluation criteria. As for the source of hiPSCs and feeder cells, biological safety evaluation of the HFF cells have been strictly reviewed by the National Institutes for Food and Drug Control (NIFDC). The hiPSC lines are pluripotent and have passed the safety evaluation. Moreover, one of the randomly selected hiPSC lines was capable of differentiating into functional neural cells and cardiomyocytes in Xeno-free culture media.

Conclusion
The clinical-grade hiPSC lines therefore could be valuable sources for future hiPSC-based clinical trials or therapies and for drug screening.
Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of Vγ9Vδ2 T cells in low levels of IL-2
Authors: Cho Hyun-Woo , Kim Su-Yeon , Sohn Dae-Hee , Lee Min-Ji , Park Mi-Young , Sohn Hyun-Jung , Cho Hyun-Il , Kim Tai-Gyu 
Published: November 2015

Abstract
Human γδ T cells play important roles in the regulation of infection and cancer. To understand the roles of costimulatory signals in activation and expansion ex vivo, Vγ9Vδ2 T cells were grown with artificial APCs that express CD83, 4-1BB ligand, and/or CD32, which allowed a loading of αCD3 and αCD28 antibodies. The costimulatory signals through CD80, 4-1BB, and CD83 ligand in low levels of IL-2 triggered an explosive ex vivo proliferation of Vγ9Vδ2 T cells capable of secreting high levels of IL-2, IFN-γ, and TNF-α. Moreover, the triple-costimulatory signals cause augmented cell viabilities for long-term growth of Vγ9Vδ2 T cells, resulting in phenotypic changes to CD27−CD45RA+ effector memory-like cells. Notably, we observed that CD83 ligand signaling is crucial to promote ex vivo expansion, survival, and cytolytic effector functions of Vγ9Vδ2 T cells. In contrast, 4-1BB signaling is moderately important in up-regulating surface molecules on Vγ9Vδ2 T cells. Consequently, γδ T cells stimulated in the presence of triple-costimulatory signals have diverse cytolytic effector molecules, including perforin, granzyme A, granzyme B, and Fas ligand, eliciting potent cytolytic activities against tumor cells. Overall, our results provide insights into the roles of costimulatory signals in manufacturing long-lived and fully functional Vγ9Vδ2 T cells that could be useful against cancers.
Changes in diagnosis rates and behavioural traits of autism spectrum disorder over time
Authors: Russell Ginny , Collishaw Stephan , Golding Jean , Kelly Susan E. , Ford Tamsin 
Published: November 2015

BackgroundThe increased proportion of UK children diagnosed with autism spectrum disorder (ASD) has been attributed to improved identification, rather than true increase in incidence.AimTo explore whether the proportion of children with diagnosis of ASD and/or the proportion with associated behavioural traits had increased over a 10-year period.MethodA cross-cohort comparison using regression to compare prevalence of diagnosis and behavioural traits over time. Participants were children aged 7 years assessed in 1998/1999 (n=8139) and 2007/2008 (n=13831).ResultsDuring 1998/1999, 1.09% (95% CI 0.86–1.37) of children were reported as having ASD diagnosis compared with 1.68% (95% CI 1.42–2.00) in 2007/2008: risk ratio (RR)=1.55 (95% CI 1.17–2.06), P=0.003. The proportion of children in the population with behavioural traits associated with ASD was also larger in the later cohort: RR=1.61 (95% CI 1.35–1.92), P<0.001. Increased odds of diagnosis at the later time point was partially accounted for by adjusting for the increased proportion of children with ASD-type traits.ConclusionsIncreased ASD diagnosis may partially reflect increase in rates of behaviour associated with ASD and/or greater parent/teacher recognition of associated behaviours.
Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study
Authors: Takiguchi Shinichiro , Fujisawa Takashi X. , Mizushima Sakae , Saito Daisuke N. , Okamoto Yuko , Shimada Koji , Koizumi Michiko , Kumazaki Hirokazu , Jung Minyoung , Kosaka Hirotaka , Hiratani Michio , Ohshima Yusei , Teicher Martin H. , Tomoda Akemi 
Published: November 2015

BackgroundChild maltreatment is a major risk factor for psychopathology, including reactive attachment disorder (RAD).AimsTo examine whether neural activity during reward processing was altered in children and adolescents with RAD.MethodSixteen children and adolescents with RAD and 20 typically developing (TD) individuals performed tasks with high and low monetary rewards while undergoing functional magnetic resonance imaging.ResultsSignificantly reduced activity in the caudate and nucleus accumbens was observed during the high monetary reward condition in the RAD group compared with the TD group (P=0.015, family-wise error-corrected cluster level). Significant negative correlations between bilateral striatal activity and avoidant attachment were observed in the RAD and TD groups.ConclusionsStriatal neural reward activity in the RAD group was markedly decreased. The present results suggest that dopaminergic dysfunction occurs in the striatum of children and adolescents with RAD, leading towards potential future risks for psychopathology.
Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation
Authors: Cheng Shaohong , Xing Weirong , Pourteymoor Sheila , Schulte Jan , Mohan Subburaman 
Published: November 2015

AbstractThe hypoxic growth plate cartilage requires hypoxia-inducible factor (HIF)-mediated pathways to maintain chondrocyte survival and differentiation. HIF proteins are tightly regulated by prolyl hydroxylase domain-containing protein 2 (Phd2)-mediated proteosomal degradation. We conditionally disrupted the Phd2 gene in chondrocytes by crossing Phd2 floxed mice with type 2 collagen-α1-Cre transgenic mice and found massive increases (&gt;50%) in the trabecular bone mass of long bones and lumbar vertebra of the Phd2 conditional knockout (cKO) mice caused by significant increases in trabecular number and thickness and reductions in trabecular separation. Cortical thickness and tissue mineral density at the femoral middiaphysis of the cKO mice were also significantly increased. Dynamic histomorphometric analyses revealed increased longitudinal length and osteoid surface per bone surface in the primary spongiosa of the cKO mice, suggesting elevated conversion rate from hypertrophic chondrocytes to mineralized bone matrix as well as increased bone formation in the primary spongiosa. In the secondary spongiosa, bone formation measured by mineralizing surface per bone surface and mineral apposition rate were not changed, but resorption was slightly reduced. Increases in the mRNA levels of SRY (sex determining region Y)-box 9, osterix (Osx), type 2 collagen, aggrecan, alkaline phosphatase, bone sialoprotein, vascular endothelial growth factor, erythropoietin, and glycolytic enzymes in the growth plate of cKO mice were detected by quantitative RT-PCR. Immunohistochemistry revealed an increased HIF-1α protein level in the hypertrophic chondrocytes of cKO mice. Infection of chondrocytes isolated from Phd2 floxed mice with adenoviral Cre resulted in similar gene expression patterns as observed in the cKO growth plate chondrocytes. Our findings indicate that Phd2 suppresses endochondral bone formation, in part, via HIF-dependent mechanisms in mice.
Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle
Authors: Lesmana Ronny , Sinha Rohit A. , Singh Brijesh K. , Zhou Jin , Ohba Kenji , Wu Yajun , Yau Winifred WY. , Bay Boon-Huat , Yen Paul M. 
Published: November 2015

Abstract
Thyroid hormone (TH) and autophagy share similar functions in regulating skeletal muscle growth, regeneration, and differentiation. Although TH recently has been shown to increase autophagy in liver, the regulation and role of autophagy by this hormone in skeletal muscle is not known. Here, using both in vitro and in vivo models, we demonstrated that TH induces autophagy in a dose- and time-dependent manner in skeletal muscle. TH induction of autophagy involved reactive oxygen species (ROS) stimulation of 5′adenosine monophosphate-activated protein kinase (AMPK)-Mammalian target of rapamycin (mTOR)- Unc-51-like kinase 1 (Ulk1) signaling. TH also increased mRNA and protein expression of key autophagy genes, microtubule-associated protein light chain 3 (LC3), Sequestosome 1 (p62), and Ulk1, as well as genes that modulated autophagy and Forkhead box O (FOXO) 1/3a. TH increased mitochondrial protein synthesis and number as well as basal mitochondrial O2 consumption, ATP turnover, and maximal respiratory capacity. Surprisingly, mitochondrial activity and biogenesis were blunted when autophagy was blocked in muscle cells by Autophagy-related gene (Atg)5 short hairpin RNA (shRNA). Induction of ROS and 5′adenosine monophosphate-activated protein kinase (AMPK) by TH played a significant role in the up-regulation of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), the key regulator of mitochondrial synthesis. In summary, our findings showed that TH-mediated autophagy was essential for stimulation of mitochondrial biogenesis and activity in skeletal muscle. Moreover, autophagy and mitochondrial biogenesis were coupled in skeletal muscle via TH induction of mitochondrial activity and ROS generation.
Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling
Authors: Hattersley Gary , Dean Thomas , Corbin Braden A. , Bahar Hila , Gardella Thomas J. 
Published: November 2015

Abstract
The PTH receptor type 1 (PTHR1) mediates the actions of two endogenous polypeptide ligands, PTH and PTHrP, and thereby plays key roles in bone biology. Based on its capacity to stimulate bone formation, the peptide fragment PTH (1–34) is currently in use as therapy for osteoporosis. Abaloparatide (ABL) is a novel synthetic analog of human PTHrP (1–34) that holds promise as a new osteoporosis therapy, as studies in animals suggest that it can stimulate bone formation with less of the accompanying bone resorption and hypercalcemic effects that can occur with PTH (1–34). Recent studies in vitro suggest that certain PTH or PTHrP ligand analogs can distinguish between two high-affinity PTHR1 conformations, R0 and RG, and that efficient binding to R0 results in prolonged signaling responses in cells and prolonged calcemic responses in animals, whereas selective binding to RG results in more transient responses. As intermittent PTH ligand action is known to favor the bone-formation response, whereas continuous ligand action favors the net bone-resorption/calcemic response, we hypothesized that ABL binds more selectively to the RG vs the R0 PTHR1 conformation than does PTH (1–34), and thus induces more transient signaling responses in cells. We show that ABL indeed binds with greater selectivity to the RG conformation than does PTH (1–34), and as a result of this RG bias, ABL mediates more transient cAMP responses in PTHR1-expressing cells. The findings provide a plausible mechanism (ie, transient signaling via RG-selective binding) that can help account for the favorable anabolic effects that ABL has on bone.
Object Salience in the Division of Labor: Experimental Evidence
Authors: Raveendran Marlo , Puranam Phanish , Warglien Massimo 
Published: November 2015

When we engage in the process of division of labor, there are typically multiple alternatives, but insufficient knowledge to choose among them. Under such conditions, we propose that not all alternatives are equally likely to be pursued. In particular, when we engage in the process of division of labor for novel and nonrepetitive production, we argue that we display a tendency to perceive and select object-based task partitions over activity-based partitions. We experimentally investigate how the salience of objects over activities manifests itself in individuals and groups engaged in division of labor for the assembly of strongly or weakly decomposable products. We draw implications for organization design as well as the impact of technological change on organizations. This paper was accepted by Jesper Sørensen, organizations.
The Effects of Age and Expertise on Product Evaluations: Does the Type of Information Matter?
Authors: Wang Jing , Cole Catherine A. 
Published: November 2015

To better understand two large consumer segments, the boomers and the echo-boomers, we examine whether and why experts and novices from these two segments rely on attribute versus benefit information in product evaluations. In four studies, we show that expertise affects younger consumers, such that younger novices evaluate products more favorably when the descriptions feature benefit information, whereas younger experts evaluate products more favorably when the descriptions feature attribute information. However, both older novices and experts evaluate products described with benefit information more favorably than those described with attribute information. We further show that differences in the perceived diagnosticity of different types of information mediate the effects of expertise and age on product evaluations. We theorize that age differences in perceived diagnosticity occur because older and younger consumers spontaneously construe information in different ways. Therefore, age differences in the effect of expertise on evaluations should disappear when construal levels are controlled. Consistent with our hypotheses, we demonstrate that when primed to construe information at concrete levels, older consumers behave just like younger consumers—older experts formed more favorable evaluations toward products described with attribute information, but older novices formed more favorable evaluations toward products described with benefit information. When younger consumers are primed to construe information at abstract levels, they prefer products described with benefit information regardless of expertise, just like older consumers. We discuss the implications of our results for both researchers and practitioners. This paper was accepted by Pradeep Chintagunta, marketing.