bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hematological Second Primary Malignancy in Pediatric Retinoblastoma: A Case Report and Systematic Review
Authors: Hyun Park Seung , Young Park Hyun , Kim Heejin , Woo Han Jung , Sook Yoon Jin 
Published: August 2024

Purpose:
The impact of heredity and treatment modalities on the development of hematologic second primary malignancies (SPMs) is unclear. This study primarily reviewed the literature on patients with hematologic SPMs after retinoblastoma.

Methods:
The PubMed and Web of Science databases were searched to identify all cases of hematologic SPMs after retinoblastoma through December 2023 (International prospective register of systematic reviews CRD42023488273).

Results:
Sixty-one patients from 35 independent publications and our case were included. Within the cohort, 15 patients (51.7%) were male, and 14 patients (48.3%) were female. Of the 43 cases with known heritability status, 27 (62.8%) were classified as heritable and 16 (37.2%) as nonheritable. The median age at diagnosis was 18 months (IQR: 7.00–36.00). The geographic distribution of patients was diverse, with North America accounting for 35.0% (21/60) of cases. The following treatment strategies were used: 11.9% (5/42) of patients received neither chemotherapy nor radiotherapy, 33.3% (14/42) received chemotherapy alone, 11.9% (5/42) received radiotherapy alone, and 42.9% (18/42) received a combination of chemotherapy and radiotherapy. The median delay between retinoblastoma diagnosis and SPM diagnosis was 40 months (IQR: 22.00–85.00). Among the 61 cases, acute myeloid leukemia accounted for 44.3% (27/61), followed by acute lymphoblastic leukemia in 21.3% (13/61), Hodgkin’s lymphoma in 11.5% (7/61), non-Hodgkin’s lymphoma in 9.8% (6/61), chronic myeloid leukemia in 3.3% (2/61), and acute natural killer cell leukemia in 1.6% (1/61).

Conclusions:
Vigilant systemic surveillance for hematologic SPMs in retinoblastoma survivors, especially those treated with systemic chemotherapy and those with hereditary conditions, is warranted to improve management strategies and patient outcomes.
Antipsychotic Treatment in People at Clinical High Risk for Psychosis
Authors: Di Lisi Alessandro , Pupo Simona , Menchetti Marco , Pelizza Lorenzo 
Published: August 2024

Purpose
The “early intervention” paradigm in psychiatry holds significant promise for preventing psychosis. Recent evidence showed that individuals at clinical high risk for psychosis (CHR-P) with antipsychotic (AP) prescription at baseline have higher psychosis transition rates compared with those without AP, although the underlying cause remains unclear. In this article, we reviewed international guidelines on early intervention in CHR-P people, paying specific attention to clinical recommendations on AP treatment. Then, we comment on these suggestions in the light of recent empirical evidence examining AP prescription in CHR-P populations within “real-world” clinical settings.

Methods
This search was conducted on PubMed/MEDLINE, PsycINFO, EMBASE, and Google, looking for both “Guidelines AND CHR-P OR UHR OR Early Psychosis.”

Results
International guidelines generally recommend not using AP as first-line treatment, but only when psychosocial interventions have failed. CHR-P people with AP drug showed high prevalence rates and had more severe clinical picture at entry. Is this a “warning signal” for potentially higher psychosis transition risk? Is it a direct AP iatrogenic effect? Is it possible to detect specific CHR-P subgroup that may benefit from AP? These are the questions that this article seeks to explore.

Conclusions
The current framework for identifying CHR-P subjects has defined psychometric criteria mainly based on positive symptoms. In our opinion, this is reductive, especially for evaluating therapeutic outcomes and prognosis. A more comprehensive assessment considering quality of life, psychiatric comorbidity, persistent negative symptoms, subjective experience of CHR-P psychopathology, and social/personal recovery is thus needed.
Engaging Oncology and Occupational Medicine to Inform Design of a Total Worker Health® Intervention to Address Employment, Financial, and Well-being Outcomes in Cancer Survivors
Authors: Tenney Liliana , Brown Carol E. , Schilz Matthew , Goering Madison , Dally Miranda , Dye-Robinson Amy , Williams Brian , Newman Lee S. , Bradley Cathy 
Published: August 2024

Objectives
Few Total Worker Health® studies and fewer interventions examine well-being in the work context of cancer survivorship. We investigated the possibility of occupation and oncology professionals working together to address employed survivors’ work-associated needs.

Methods
We employed a community-based participatory research approach to examine the educational, contextual, and workflow needs of oncology care team members to inform intervention design. Focus groups were conducted with oncology care team members and occupational medicine physicians. Key themes from each group were then examined.

Results
Themes included oncology care team’s role in helping patients navigate resources, providing psychosocial support, and educating patients. Major themes for ways to better provide employment-related support during treatment included referring patients to employment experts and providing education on employment support.

Conclusions
Occupational health professionals in collaboration with oncology clinics could play an important role in assisting cancer survivors’ ability to navigate employment challenges.
Comparison of Outcomes with the Use of Different Heat-Activated Crimping Prostheses in Stapedotomy
Authors: Ni Garrett , Monos Stylianos , Kortebein Sarah , Symms John , Ettyreddy Abhinav , Hillman Todd A. , Chen Douglas A. 
Published: August 2024

ObjectiveTo determine differences in failure rate and hearing outcomes of a completely encircling heat-activated crimping prosthesis (SMart 360°) compared to partially encircling prosthesis (SMart).Study DesignRetrospective chart review.SettingPrivate neurotology tertiary referral center.PatientsPatients who underwent stapedotomies performed by the senior authors from 2008 to 2019 using the SMart prosthesis and SMart 360° prothesis.InterventionsStapedotomy operations with placement of a SMart or SMart 360° prosthesis.Main Outcome MeasuresIncidence of early failure requiring revision surgery. Differences in preoperative air–bone gap (ABG) compared to postoperative ABG at 3 months, 1 year, and 2 years after surgery.ResultsA total of 228 stapedotomies were performed (SMart n = 48 and SMart 360° n = 180). Mean preoperative ABG for SMart and SMart 360° were 26.15 and 29 dB, respectively. The mean difference in ABG for the SMart at 3 months, 1 year, and 2 years were 17, 18, and 11 dB, respectively. The mean difference in ABG for the SMart 360° at 3 months, 1 year, and 2 years were 20, 20, and 19 dB. ABG differences at 3 months (p= 0.10) and 1 year (p= 0.36) were not statistically different. The failure rate for the SMart prosthesis was 12.5% and for the SMart 360° 2.2% (p= 0.002).ConclusionsThere were no statistically significant differences in ABG changes for SMart compared to SMart 360°. The Smart 360 corrects the problem with early failure seen with the Smart prosthesis.Professional Practice Gap and Educational NeedDetermination of most efficacious stapes prosthesis.Learning ObjectiveWhich stapes prosthesis produces better hearing results with fewer failures.Desired ResultTo disseminate information necessary to choose the best stapes prosthesis for patients.Level of EvidenceLevel IIIIndicate IRB or IACUC2022-029-agh
Differentiating Definite and Probable Ménière Disease: A Comprehensive Evaluation of Audio-Vestibular Function Testing Combined with Inner Ear MRI
Authors: Guo Xiaojing , Xiao Heng , Huang Gengliang , Lin Chenxin , Lin Jianwei , Cai Huimin , Ke Xiaoying , Lu Yang , Ye Shengnan 
Published: August 2024

Objectives
To evaluate the differences between audio-vestibular function testing and inner ear gadolinium magnetic resonance imaging (MRI) in distinguishing definite Ménière disease (DMD) and probable Ménière disease (PMD), and to provide a reference for early clinical diagnosis and intervention.

Methods
A total of 116 patients diagnosed with DMD (n = 80) and PMD (n = 36) were enrolled. The differences in the results of pure tone audiometry, caloric test, and tympanic injection of gadolinium for contrast-enhanced MRI between the two groups were compared and analyzed. Parameters that could differentiate between the two conditions were identified, and the sensitivity and specificity and the area under the curve (AUC) of individual and combined indices in the differential diagnosis of DMD and PMD were evaluated.

Results
The hearing threshold and hearing asymmetry rate of the DMD group were significantly higher than those of the PMD group (p < 0.001), 98.8% and 30.6%, respectively. The abnormal rates of canal paresis (CP) and severity of endolymphatic hydrops in the DMD group were higher than those in the PMD group (p < 0.05). When combined with high-frequency hearing thresholds, hearing asymmetry, hearing curve type, endolymphatic hydrops, and abnormal CP, the diagnostic accuracy of DMD was improved compared to using high-frequency alone (p < 0.05).

Conclusion
This study showed that PMD and DMD may represent two different stages in the development of MD disease. The comprehensive assessment of audio-vestibular function testing and inner ear MRI proves beneficial for early diagnosis, potentially contributing to the preservation of inner ear function.
Risk Factors for Recurrence of Benign Paroxysmal Positional Vertigo: A Prospective Study
Authors: Maas Britta D.P.J. , Hacarlioglugil Emre , van Leeuwen Roeland B. , Kamphuis Stephan , Schermer Tjard R. , van Benthem Peter Paul G. , Bruintjes Tjasse D. 
Published: August 2024

Objectives
Benign paroxysmal positional vertigo (BPPV) can be treated successfully in most cases. However, recurrences are common. We aimed to prospectively investigate demographic and clinical risk factors for BPPV recurrence. Our second aim was to investigate whether seasonality affects recurrences.

Methods
We recruited adult Dutch patients presenting at our dizziness clinic with a diagnosis of definite or possible BPPV for a prospective observational study with 1-year follow-up. Factors collected from patient history and questionnaires were age, sex, ethnicity, previous treatment for BPPV, duration of BPPV symptoms, number of treatment sessions for the initial BPPV episode, the affected canal, recent head trauma, and a history of vestibular neuritis, Menière's disease, (vestibular) migraine, gout, diabetes mellitus, and chronic renal failure. Factors derived from blood samples were uric acid, glycated hemoglobin, and 25-hydroxyvitamin D.

Results
We included 139 subjects with a mean age of 65 (SD, 13) years, of whom 70% was female. A total of 48 subjects (34.5%) suffered from at least one recurrence during the 1-year follow-up. Independent risk factors for recurrence of BPPV were “multiple treatment sessions for the initial BPPV episode” (incidence rate ratio, 1.74; 95% confidence interval 1.06–2.85; p = 0.027) and history of gout (incidence rate ratio, 1.90; 95% confidence interval, 1.01–3.57; p = 0.045).

Conclusion
One-third of patients presenting in a tertiary dizziness clinic develop at least one recurrence of BPPV within 1 year. Multiple treatment sessions and a history of gout are independent risk factors for recurrence.
Association Between the Inflammatory Potential of Diet and Constipation Among Adults in the United States
Authors: Lu Wang Feng , Liu Lei , Zhang Yong Hong , Liu Huanxian 
Published: August 2024

Objective:
To investigate the potential association between Dietary Inflammatory Index (DII) scores and constipation among a sample of adults in the United States.

Methods:
This cross-sectional study used data from adult participants in the 2005 to 2010 National Health and Nutrition Examination Survey (ie, “NHANES”). Self-reported information was used to identify cases of constipation. The DII was used to assess inflammatory potential of the diet. Odds ratios (ORs) and corresponding 95% CIs for the association between the DII and constipation were determined using multivariate logistic regression modeling. Stratified analyses explored whether there was effect modification to influence the relationship between DII and constipation.

Results:
Of 8272 subjects, 759 reported constipation, and 7513 did not, corresponding to a prevalence of 9.2%. After adjusting for age, gender, race/ethnicity, marital status, education level, smoking status, alcohol consumption, physical activity, body mass index (BMI), cardiovascular diseases (CVD), hypertension, stroke, diabetes, energy intake, carbohydrate intake, and selective serotonin reuptake inhibitor (SSRI) use. Compared with lower DII scores group T1 (−5.28 to ≤0.72), the adjusted OR values for DII scores and constipation in T2 (>0.72 to ≤2.50) and T3 (>2.50 to 5.24) were 1.27 (95% CI: 1.02–1.58, P=0.029) and 1.43(95% CI: 1.14–1.8, P=0.002). Subgroup analyses showed that there were effect modification of gender and physical activity factors on DII scores and constipation.

Conclusions:
Results of this cross-sectional study suggest that a higher dietary inflammatory index score was associated with increased risk of constipation after adjustment for confounding in a multivariable analysis. gender and physical activity were found to be an effect modifier of this relationship.
Trajectories and Transitions in Service Use Among Older Veterans at High Risk of Long-Term Institutional Care
Authors: Bouldin Erin D. , Brintz Ben J. , Hansen Jared , Rupper Rand , Brenner Rachel , Intrator Orna , Kinosian Bruce , Viny Mikayla , Dang Stuti , Pugh Mary Jo ,   on behalf of the Elizabeth Dole Center of Excellence for Veteran and Caregiver Research Team
Published: August 2024

Background:
We aimed to identify combinations of long-term services and supports (LTSS) Veterans use, describe transitions between groups, and identify factors influencing transition.

Methods:
We explored LTSS across a continuum from home to institutional care. Analyses included 104,837 Veterans Health Administration (VHA) patients 66 years and older at high-risk of long-term institutional care (LTIC). We conduct latent class and latent transition analyses using VHA and Medicare data from fiscal years 2014 to 2017. We used logistic regression to identify variables associated with transition.

Results:
We identified 5 latent classes: (1) No Services (11% of sample in 2015); (2) Medicare Services (31%), characterized by using LTSS only in Medicare; (3) VHA-Medicare Care Continuum (19%), including LTSS use in various settings across VHA and Medicare; (4) Personal Care Services (21%), characterized by high probabilities of using VHA homemaker/home health aide or self-directed care; and (5) Home-Centered Interdisciplinary Care (18%), characterized by a high probability of using home-based primary care. Veterans frequently stayed in the same class over the three years (30% to 46% in each class). Having a hip fracture, self-care impairment, or severe ambulatory limitation increased the odds of leaving No Services, and incontinence and dementia increased the odds of entering VHA-Medicare Care Continuum. Results were similar when restricted to Veterans who survived during all 3 years of the study period.

Conclusions:
Veterans at high risk of LTIC use a combination of services from across the care continuum and a mix of VHA and Medicare services. Service patterns are relatively stable for 3 years.
Genetic testing for pediatric sensorineural hearing loss in the era of gene therapy
Authors: Shearer A. Eliot 
Published: August 2024

Purpose of review
To summarize indications, methods, and diagnostic yields for genetic testing for pediatric hearing loss.

Recent findings
Genetic testing has become a cornerstone of clinical care for children with sensorineural hearing loss. Recent studies have shown the efficacy of gene panels and exome sequencing for any child with sensorineural hearing loss. Recent findings have underscored the importance of a diagnosis in clinical care. Clinical trials for gene therapy for hearing loss have begun.

Summary
Genetic testing has become critical for personalized care for children with hearing loss. Recent studies have shown a 43% overall diagnostic yield for genetic testing for pediatric hearing loss, though the diagnostic yield may range from 10 to 60% depending on clinical features. Syndromic diagnoses comprise 25% of positive genetic tests for pediatric sensorineural hearing loss. While diagnostic yield is lower for children with unilateral or asymmetric sensorineural hearing loss, the likelihood of syndromic hearing loss finding is higher. An early and accurate genetic diagnosis is required for participating in clinical trials for gene therapy for hearing loss.
Biomarkers in Pediatric Hemophagocytic Lymphohistiocytosis With Central Nervous System Involvement: A Cohort Study
Authors: Zhao Yunze , Ou Wenxin , Wei Ang , Ma Honghao , Zhang Liping , Lian Hongyun , Zhang Qing , Wang Dong , Li Zhigang , Zhang Rui , Wang Tianyou 
Published: August 2024

Background:
The aim of this study was to analyze the clinical significance of cerebrospinal fluid (CSF) cytokines in hemophagocytic lymphohistiocytosis associated with central nervous system (CNS-HLH).

Methods:
CSF cytokine levels, including interferon (IFN)-γ, soluble CD25 (sCD25), interleukin (IL)-6, IL-10, IL-18, and CXCL9 were measured at disease onset and during the treatment. Five newly diagnosed patients with demyelination disease were enrolled for comparison.

Results:
Sixty-five samples from 36 patients (13 in the CNS group and 23 in the non-CNS group) were detected. Levels of CSF IFN-γ, sCD25, IL-10, IL-18, and CXCL9 in the CNS group were higher than those in the non-CNS group (P=0.038, <0.001, <0.001, 0.005, and <0.001), and levels of CSF sCD25, IL-10, IL-18, and CXCL9 in the CNS group were higher than those in the demyelination group (P=0.001, 0.008, 0.004, and 0.003). There was no significant difference in IL-6 levels among the 3 groups (P=0.339). CSF IFN-γ, sCD25, IL-10, IL-18, and CXCL9 could assist in diagnosing CNS-HLH. The diagnostic efficiency of CSF sCD25, IL-10, and CXCL9 was better, with a cutoff value of 154.64, 1.655, and 19.54 pg/mL, respectively. The area under the curve was >0.9, with sensitivity and specificity >80%. Correlation analysis suggested that in the CNS group, IFN-γ levels in CSF and serum correlated positively (R=0.459, P=0.007), while there was no correlation between CSF CXCL9 and serum IFN-γ (P=0.915).

Conclusions:
CSF IFN-γ, sCD25, IL-10, IL-18, and CXCL9 levels were significantly higher in HLH patients with CNS involvement than those without and could predict HLH patients with CNS involvement. CSF CXCL9 might be a more sensitive biomarker to CNS-HLH than IFN-γ, while CSF IL-6 does not seem to play a vital role.
Determinants of Surgical Approach for Benign Outpatient Hysterectomy
Authors: Whiteside James L. , Tumin Dmitry , Hildebrand Jason P. , Harris Alyssa 
Published: August 2024

(Abstracted from J Minim Invasiv Gynecol 2024;31(2):123–130.e2
Hysterectomy is the most common nonobstetric major surgery among women, accounting for roughly 400,000 surgeries in the United States annually. Minimally invasive approaches to this surgery are becoming more common, with many factors influencing the decision about the approach for the procedure.
Ovarian Torsion: A Review of the Evidence
Authors: Zhu Ting-Wei , Li Xue-Lian 
Published: August 2024

AbstractImportanceOvarian torsion is a gynecological emergency caused by the twisting of the ovary and/or fallopian tube, further resulting in ischemic changes of the adnexa. Early diagnosis is likely to preserve ovarian function.ObjectiveThe purpose of this review is to review the current findings of ovarian torsion including clinical presentations, diagnostic criteria, surgical procedures, and prognosis.Evidence AcquisitionThe literature search is mainly available in PubMed and Web of Science platforms by searching “ovarian torsion” combined with one or several terms including “diagnosis” “risk factors” “surgery” and “torsion recurrence.”ResultsAbdominal pain, nausea, and vomiting were normal clinical presentations. In order to increase the accuracy of diagnosis, it is necessary to integrate clinical presentation and the findings of imaging and laboratory examinations. Computed tomography findings, plasmad-dimer level, and the time from pain onset play a critical role in distinguishing ovarian necrosis. The efficiency of oophoropexy on preventing recurrent ovarian torsion is controversial.ConclusionMost patients with early diagnosis of ovarian torsion may have a better prognosis with conservative surgery.RelevanceBetter understanding of ovarian torsion is critical for gynecologists to promote accuracy of diagnosis and select the optimal surgical procedure.Target AudienceObstetricians and gynecologists, family physiciansLearning ObjectivesAfter completing this activity, the learner will be better able to explain clinical manifestations and findings of imaging; identify signs of ischemic necrosis in twisted ovaries; and discuss the optimal surgery for different populations of women with ovarian torsion.
Patterns of HIV Treatment Preferences Among People With Diverse Demographic, Social, and Behavioral Characteristics Who Are Living With HIV in the United States
Authors: Russell Elizabeth S. , Zhou Mo , Song Yan , Barak Narquis , Gao Yipeng , Mast T. Christopher 
Published: August 2024

Background:
New dosage form and frequency options may improve HIV treatment outcomes and reduce disparities in access and use.

Methods:
People with HIV in the United States completed a demographic and discrete choice experiment survey of preference for 13 hypothetical HIV treatment options: daily and weekly oral tablets; 1-, 3-, or 6-monthly injections by self or a health care provider (HCP); yearly implant; or combinations. Best-Worst Scaling and a latent class model were used to analyze overall preference choices and for groups of individuals with similar patterns of preferences; the model also predicted uptake of products.

Results:
Among the diverse 829 respondents, weekly oral tablets and 6-monthly injections by an HCP were significantly more favored than daily oral tablets. Convenience of the treatment and being tired of taking pills were the top drivers of preference responses. Latent class analysis identified 4 groups of respondents with distinct preference patterns; approximately two-thirds belonged to groups strongly preferring products other than daily oral tablets. The modelled uptake of a weekly pill, yearly implant, 6-monthly HCP injection, oral daily pill, and 3-monthly HCP injections were 24%, 24%, 24%, 18%, and 11%, respectively.

Conclusions:
Patterns of HIV medication preference can inform development of new forms of HIV therapy products because the majority of patients do not prefer the currently most available treatment option of daily oral tablets. Looking beyond population-level preferences and into similar groups of people with HIV increases the ability to develop patient-centered products to fill gaps in care and increase treatment effectiveness.