bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut microbiota and sleep: Interaction mechanisms and therapeutic prospects
Authors: Lin Zhonghui , Jiang Tao , Chen Miaoling , Ji Xudong , Wang Yunsu 
Published: July 2024

Abstract
Sleep is crucial for wellness, and emerging research reveals a profound connection to gut microbiota. This review explores the bidirectional relationship between gut microbiota and sleep, exploring the mechanisms involved and the therapeutic opportunities it presents. The gut–brain axis serves as a conduit for the crosstalk between gut microbiota and the central nervous system, with dysbiosis in the microbiota impairing sleep quality and vice versa. Diet, circadian rhythms, and immune modulation all play a part. Specific gut bacteria, like Lactobacillus and Bifidobacterium, enhance sleep through serotonin and gamma-aminobutyric acid production, exemplifying direct microbiome influence. Conversely, sleep deprivation reduces beneficial bacteria, exacerbating dysbiosis. Probiotics, prebiotics, postbiotics, and fecal transplants show therapeutic potential, backed by animal and human research, yet require further study on safety and long-term effects. Unraveling this intricate link paves the way for tailored sleep therapies, utilizing microbiome manipulation to improve sleep and health. Accelerated research is essential to fully tap into this promising field for sleep disorder management.
Study on the effect of LuCl3 doping on the characteristics of titanium alloy micro-arc oxidation coatings
Authors: Wang Xiangjie , Wang Ping , Duan Yanfei , Luo Xu , Zheng Youping 
Published: July 2024

Abstract
The micro-arc oxidation of TC4 titanium alloy was carried out by adding LuCl3. The effect of LuCl3 addition on the properties of the micro-arc oxidized coatings, and the rate of weight loss by erosion under simulated oil field conditions, were analysed. The results show that the increase of oxidation voltage after the addition of LuCl3 makes the surface structure of the coatings denser. The coating is mainly composed of Rutile TiO2, Anatase TiO2, and a small amount of Lu2O3 phase. The kinetic potential polarization curves showed that the addition of LuCl3 can increase the corrosion potential and decrease the corrosion current density of TC4 titanium alloy, and at the same time reduce the rate of erosion weight loss of micro-arc oxidized coatings under simulated oilfield conditions. The overall performance of the coatings is best when the concentration of LuCl3 is 0.3 g L−1.
In-silico screening of bioactive compounds of Moringa oleifera as potential inhibitors targeting HIF-1α/VEGF/GLUT-1 pathway against Breast Cancer
Authors: Masarkar Neha , Pal Maynak , Roy Mithun , Yadav Ashish K. , Pandya Bharati , Lokhande Suryabhan , Kanwar Jagat R. , Ray Suman Kumar , Mukherjee Sukhes 
Published: July 2024

Abstract

Objectives
Breast cancer is among the most heterogeneous and aggressive diseases and a foremost cause of death in women globally. Hypoxic activation of HIF-1α in breast cancers triggers the transcription of a battery of genes encoding proteins that facilitate tumor growth and metastasis and is correlated with a poor prognosis. Based on the reported cytotoxic and anti-cancer properties of Moringa oleifera (Mo), this study explores the inhibitory effect of bioactive compounds from M. oleifera and breast cancer target proteins HIF-1α, VEGF, and GLUT-1 in silico.

Methods
The X-ray crystallographic structures of HIF-1α, VEGF, and GLUT1 were sourced from the Protein Data Bank (PDB) and docked with 70 3D PubChem structures of bioactive compounds of M. oleifera using AutoDock Vina, and binding modes were analyzed using Discovery Studio. Five compounds with the highest binding energies were selected and further drug-likeness, oral bioavailability, ADME, and toxicity profiles were analyzed using SwissADME, ADMETSaR, and ADMETlab 3.0 web server.

Results
Out of the screened 70 bioactive compounds, the top five compounds with the best binding energies were identified namely Apigenin, Ellagic Acid, Isorhamnetin, Luteolin, and Myricetin with each receptor. Molecular docking results indicated that the ligands interact strongly with the target HIF-1α, VEGF, and GLUT-1 receptors through hydrogen bonds and hydrophobic interactions. These compounds showed favorable drug-like and pharmacokinetic properties, possessed no substantial toxicity, and were fairly bioavailable.

Conclusions
Results suggested that the compounds possess strong potential in developing putative lead compounds targeting HIF-1α that are safe natural plant-based drugs against breast cancer.
Enhanced Jaya optimization for improving multilayer perceptron neural network in urban air quality prediction
Authors: Abu Doush Iyad , Sultan Khalid , Alsaber Ahmad , Alkandari Dhari , Abdullah Afsah 
Published: July 2024

AbstractThe multilayer perceptron (MLP) neural network is a widely adopted feedforward neural network (FNN) utilized for classification and prediction tasks. The effectiveness of MLP greatly hinges on the judicious selection of its weights and biases. Traditionally, gradient-based techniques have been employed to tune these parameters during the learning process. However, such methods are prone to slow convergence and getting trapped in local optima. Predicting urban air quality is of utmost importance to mitigate air pollution in cities and enhance the well-being of residents. The air quality index (AQI) serves as a quantitative tool for assessing the air quality. To address the issue of slow convergence and limited search space exploration, we incorporate an opposite-learning method into the Jaya optimization algorithm called EOL-Jaya-MLP. This innovation allows for more effective exploration of the search space. Our experimentation is conducted using a comprehensive 3-year dataset collected from five air quality monitoring stations. Furthermore, we introduce an external archive strategy, termed EOL-Archive-Jaya, which guides the evolution of the algorithm toward more promising search regions. This strategy saves the best solutions obtained during the optimization process for later use, enhancing the algorithm’s performance. To evaluate the efficacy of the proposed EOL-Jaya-MLP and EOL-Archive-Jaya, we compare them against the original Jaya algorithm and six other popular machine learning techniques. Impressively, the EOL-Jaya-MLP consistently outperforms all other methods in accurately predicting AQI levels. The MLP model’s adaptability to dynamic urban air quality patterns is achieved by selecting appropriate values for weights and biases. This leads to efficacy of our proposed approaches in achieving superior prediction accuracy, robustness, and adaptability to dynamic environmental conditions. In conclusion, our study shows the superiority of the EOL-Jaya-MLP over traditional methods and other machine learning techniques in predicting AQI levels, offering a robust solution for urban air quality prediction. The incorporation of the EOL-Archive-Jaya strategy further enhances the algorithm’s effectiveness, ensuring a more efficient exploration of the search space.
Effect of flax sheet prepared by wet-laying technology on tensile properties of flax/polypropylene composites
Authors: Wang Ting , Zhang Xinyu , Wang Yefan , Guo Zhihua , Wang Qian , Liu Sheng , Miao Ze , Liao Xiaoyuan , Liu Haitang 
Published: July 2024

Abstract
This work focuses on the flax sheet which is prepared for wet-laying technique, then investigated the effect of the flax sheet preparation process on the tensile strength of the flax/polypropylene composites. Using hand-laying and hot-pressing methods to prepare composite materials. Then tested tensile strength of composites under different revolutions of fiber disintegration machine, flax content and flax length. The results shown that when the number of revolutions is 25,989 r, the flax content is 7.88 g, and the flax length is 4 mm, the highest tensile strength is 42.0376 MPa, which is 78.88 % stronger than that of pure polypropylene.
The morphosyntax of Ezafe in Southern Zazaki
Authors: Gündoğdu Songül , Kahnemuyipour Arsalan , Peters Sable 
Published: July 2024

Abstract
The present study describes and analyzes the morphosyntactic expression of the Southern Zazaki Ezafe – a linking element in the nominal domain common among Iranian languages. This morpheme is used to link modifiers (i.e. adjectives and possessors) to their head nouns as follows: n-ez1 mod1-ez2 mod2-ez3 mod3. Southern Zazaki, like other languages of the Kurdish region (and unlike, e.g. Persian) reflects phi-features (and case) of the head noun on each Ezafe morpheme in a noun phrase. This paper is focussed around two morphosyntactic puzzles that arise in Southern Zazaki. First, while the Ezafe marker in general reflects the case of the entire DP, the presence of a possessor produces invariant oblique case, regardless of the case value assigned to the DP externally (Paul, Ludwig. 2009. Zazaki. In Gernot Windfuhr (ed.), The Iranian languages, 545–586. Routledge; Todd, Terry Lynn. 2002. A grammar of Dimili. Also known as Zaza. Stockholm: Iremet Forlag; Toosarvandani, Maziar & Coppe van Urk. 2014. The syntax of nominal concord: What Ezafe in Zazaki shows us. Proceedings of NELS 43(2). 209–220 i.a.). Second, Southern Zazaki uniquely employs a separate series of “D-form” Ezafe morphemes in certain syntactic contexts (Keskin, Mesut. 2010. Zazaca üzerine notlar (Notes on Zazaki). In Şükrü Aslan (ed.), Herkesin Bildiugi Sır: Dersim. Iletisim, 221–244; Paul, Ludwig. 2009. Zazaki. In Gernot Windfuhr (ed.), The Iranian languages, 545–586. Routledge; Todd, Terry Lynn. 2002. A grammar of Dimili. Also known as Zaza. Stockholm: Iremet Forlag; Werner, Brigitte. 2018. Forms and meanings of the Ezafe in Zazaki. In Saloumeh Gholami (ed.), Endangered Iranian languages. Reichert Verlag i.a.). This study aims to provide a cohesive analysis of Ezafe in Southern Zazaki both with respect to its general phi- and case-sensitive realizations, as well as the distribution of D-forms.
Wronskian solution, Bäcklund transformation and Painlevé analysis to a (2 + 1)-dimensional Konopelchenko–Dubrovsky equation
Authors: Gao Di , Ma Wen-Xiu , Lü Xing 
Published: July 2024

Abstract
The main work of this paper is to construct the Wronskian solution and investigate the integrability characteristics of the (2 + 1)-dimensional Konopelchenko–Dubrovsky equation. Firstly, the Wronskian technique is used to acquire a sufficient condition of the Wronskian solution. According to the Wronskian form, the soliton solution is obtained by selecting the elements in the determinant that satisfy the linear partial differential systems. Secondly, the bilinear Bäcklund transformation and Bell-polynomial-typed Bäcklund transformation are derived directly via the Hirota bilinear method and the Bell polynomial theory, respectively. Finally, Painlevé analysis proves that this equation possesses the Painlevé property, and a Painlevé-typed Bäcklund transformation is constructed to solve a family of exact solutions by selecting appropriate seed solution. It shows that the Wronskian technique, Bäcklund transformation, Bell polynomial and Painlevé analysis are applicable to obtain the exact solutions of the nonlinear evolution equations, e.g., soliton solution, single-wave solution and two-wave solution.
Vernacular Houses in Nineteenth-Century California
Authors: Day Linda L. 
Published: July 2024

Colonists and settlers of nineteenth-century California built simple houses with available materials and skills. This bounded case study of selected Northern California houses for artisans, agriculture workers, shopkeepers, public servants, gold diggers, and industrial workers is informed by Dell Upton’s vernacular housing studies. It explains how specific regional contexts influenced local dwelling design, construction, and amenities, while acknowledging that housing was a part of larger economic, transportation, and information networks.
Early Spanish/Mexican pueblo (town) and rancho (cattle ranch) adobes were typically one-room buildings with thatched roofs, dirt floors, and few windows. Construction of adobes was time-consuming and produced high-maintenance structures better suited to Southern California than to the high-rainfall, forested landscapes to which the Gold Rush drew American and international settlers. These newcomers sought shelter in tents or in crudely constructed log- and wood-frame dwellings. As the cultural context evolved from Spanish/Mexican to American/Northern European dominance, trade and immigration increased, with adobe and wood-frame builders taking advantage of the transition from an economy controlled by Spain and Mexico to one shaped by international market forces. Increased economic prosperity, the emergence of a California merchant class, industrialization of lumber production, the arrival of immigrants with building skills, and the growing availability of new and readily available building materials improved California’s housing stock. Interspersed among crude frontier shelters came adobes with stone foundations, wood floors, and interior fireplaces, and redwood cottages framed of dimensional, sawmill-cut lumber. By the end of the nineteenth century, wood structures outnumbered those of adobe. While wood prevailed as a structural material, builders often reproduced the form, massing, and style of earlier adobes, as expressed in the California ranch houses that were twentieth-century America’s most popular housing style.
Relationships between body length, body mass and otolith dimensions in three Sprat species (Teleostei: Ehiravidae) from the Caspian Sea
Authors: Shariati Mohammad Reza , Alavi-Yeganeh Mohammad Sadegh , Ghanbarifardi Mehdi 
Published: July 2024

AbstractReliable and detailed knowledge regarding the relationship between otolith size and the size of fish is important for fisheries management and for ecological studies on predicting fish size and on predator–prey interactions. Therefore, these relationships are estimated for three sprat (genus Clupeonella) species, including C. caspia, C. engrauliformis and C. grimmi from the Caspian Sea. The relative size and mass of the otoliths corrected for body size and mass were also estimated for the three sprat species. After biometry of collected specimens, the Sagittal otoliths were extracted from the cranium of collected specimens and photographed. Photos were used to estimate length and width of otoliths. The results revealed significant relationships between otolith length and width vs. fish length and otolith mass vs. body mass in all three species (r2 > 0.5). The higher coefficient of determination (r2) for relationships between total length (fish) – Otolith length and width was concluded in comparison with relationships between fish mass and otolith mass in the studied sprat species. Otoliths of C. grimmi showed the highest relative length and were significantly (P < 0.05) heavier than sagittal otoliths of two other sprat species. There is no previous report on size–mass relationships between fish and otolith measurements among the three studied sprat species. These estimated equations can be used in back-calculation studies, especially for these three sprats as the dominant prey for piscivorous predators such as Caspian seals and sturgeons, in their habitats.
The issue of sustainable land use in Ukraine taking into account the consequences of the war
Authors: Datsenko Liudmyla , Titova Svitlana , Dubnytska Marharyta , Kustovska Oksana 
Published: July 2024

Aim of the studyThe purpose of the study is to consider the issue of sustainable land use in Ukraine, taking into account the consequences of the war. The legal definition of sustainable land use is currently not sufficiently justified and balanced. In Ukraine today, the paradigm of sustainable (balanced) land use is still being formed, and the Land Policy Strategy for the management of land resources and land use should be based on it.Material and methodsThe method of analysis is used to determine the possibilities of a more rapid development of the socially oriented market economy after the war. This can happen thanks to the deepening of the theoretical foundations of the rational use of land resources (the synthesis method), optimization of the economic, social and ecological components of land use (deduction method), which in turn will contribute to increasing the socio - economic efficiency of the use and reproduction of the productive potential of Ukraine's lands in the post-war period (system approach).Results and conclusionsIt was determined that sustainable (balanced) land use should be understood as a system of organizing the use and protection of land and other natural resources and biodiversity and corresponding land relations corresponding to the relations of social development, in which the optimal relationship between social, ecological and economic factors of land use development is achieved. The essence of the research component of the institutionalization of balanced land use is disclosed. A paradigm of views on sustainable land use is formulated, taking into account the consequences of the war in Ukraine.
Morfología del mercado laboral en Colombia
Authors: Nieto Emmanuel 
Published: July 2024

En este artículo se establecen las tendencias del mercado de trabajo durante la última década. En el comportamiento ascendente de la oferta de mano de obra se destaca el acentuado crecimiento de la participación laboral de las mujeres. Desde la perspectiva de la demanda de mano de obra. resalta el fenómeno de la terciarización del mercado de trabajo. La prestación de servicios es la actividad de mayor dinamismo en la generación de puestos de trabajo. lo cual contrasta con el lánguido comportamiento de sectores como la agricultura. la construcción y la industria. Los desequilibrios del mercado laboral se expresan en creciente desempleo.i nformalidad. subempleoy empleo temporal. Los grupos más vulnerables al desempleo siguen siendo las mujeres y los jóvenes. El desempleo cíclico alcanza niveles pocas veces registrado en la historia reciente del país. sin embargo. más que un problema cuantitativo, el desajuste laboral es asunto de calidad del empleo y bajos salarios que repercute negativamente en las condiciones de vida de los colombianos. A ello se debe la asociación directa con los altos índices de pobreza y la acentuada concentración del ingreso. Al final del artículo se presentan las políticas y los programas de empleo que se han venido debatiendo en el país durante el último año. Esas propuestas son distintas por su origen. tiempo y concepción. En tanto proceden de actores con intereses no siempre coincidentes. algunas son incluso contradictorias.
Teoría y práctica de la salud pública
Authors: Franco Agudelo Saúl 
Published: July 2024

Les pido que por un momento nos desprendamos de la imagen profesional de salud pública, abstengámonos por un momento de pensar, que salud pública es aquello que hacen los salubristas.No pensemos que salud pública es un hacer burocrático, administrativo, es algo de eso, pen en este primer intento de pensamiento nos puede opacar la visibilidad de campo.
El precio de la paz en el vacío ético y social
Authors: S. J. Francisco de Roux 
Published: July 2024

Yo quisiera tocar solamente algunos puntos, que parecen importantes para discutir dentro del contexto tan amplio de Alfredo de los Rios, abierto en la magnífica intervención de esta mañana y por eso voya a ser concientemente simple.En algunas cosas voy a hacer afirmaciones que desafortunadamente no tenemos tiempo para elaborarlas con toda su urgencia y por lo mismo quisiera que esas afirmaciones me las oigan con la mayor simpleza, yo diría casi con humildad, porque son absolutamente discutibles.
El programa de crecimiento y desarrollo: una alternativa basada en el desarrollo humano, de los derechos y la educación
Authors: Peñaranda C Fernando 
Published: July 2024

Los tres primeros años de vida constituyen una etapa fundamental para el desarrollo de la persona. La precaria calidad de vida en que muchas familias de nuestro país llevan a cabo sus funciones de crianza configuran ambientes pocos propicios para el sano desarrollo de los niños. En este contexto, el programa de crecimiento y desarrollo cobra especial significado, por lo cual el cambio de orientación introducido por la Resolución 412 de 2000 del Ministerio de Salud, desde una visión morbicéntrica, es preocupante. Esta orientación dificulta la comprensión del problema desde una perspectiva integral, lo cual deviene en una visión monosectorial y descontextualizada socioeconómica, cultural y políticamente. Se presenta una propuesta basada en la recuperación de una perspectiva de promoción de la salud centrada en el desarrollo humano, reconociendo en le programa un instrumento para garantizar los derechos de los niños y la satisfacción de sus necesidades, como mecanismo de legitimación del Estado. Para esto el programa deberá reconocer al adulto significativo como sujeto así como la importancia de su participación en la orientación del programa, generar instancias de apoyo emocional y recuperación del tejido social, instaurar un modelo educativo dirigido a promover el desarrollo humano, garantizar un programa de calidad abierto a todos, recuperar las funciones de la salud pública y promover la construcción de una política pública en niñez que dinamice la articulación de los sectores que se requieren para consolidar una perspectiva integral.
Participación social en salud: un reto para la promoción del salud
Authors: Restrepo Helena 
Published: July 2024

La participación social es un proceso fundamental en al implementación de proyectos y la implementación de proyectos y experiencias de promoción de la salud (PS). Las comunidades transforman sus condiciones de vida cuando adquieren a través de los procesos participativos la capacidad de definir sus problemas, necesidades y soluciones a ellos. La perspectiva de género es una nueva forma de concebir las relaciones hombre – mujer en la sociedad. La participación de la mujer en programas de salud ha estado íntimamente ligada a la forma en que se concibe generalmente el papel de la mujer como cuidadora de la salud en la familia y de los grupos especiales, de ahí la importancia de dar una nueva visión del papel de la mujer en PS. En este artículo se llama la atención sobre la importancia y el potencial que tiene la participación con el enfoque de género para promover la salud y para disminuir las inequidades y desigualdades en salud. Se ilustra con un caso de experiencia participativa colombiana en la cual la mujer fue la protagonista principal del mejoramiento de la salud y condiciones sociales de la comunidad.
In memorian
Authors: Londoño de la Cuesta Juan Luis 
Published: July 2024

En días pasados, el ministro de la protección social, el finado doctor Juan Luis Londoño de la Cuesta, había enviado a la Dirección de la revista una presentación con la intención de que se convirtiera en un artículo de nuestra publicación; tal propósito no se realizó. Sin embargo, lo presentamos en este número tal como él la envió como un homenaje a quien se distinguió por su trabajo, su fe y su compromiso por el país.