bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and abandonment and outcome of treatment in 67 Chinese children with medulloblastoma
Authors: Wang Chen , Yuan Xiao-Jun , Jiang Ma-Wei , Wang Li-Feng 
Published: October 2015

OBJECTThe purpose of this study was to explore the clinical features and outcome of medulloblastoma in Chinese children. The authors analyze the reasons that treatment is abandoned and attempt to provide evidence-based recommendations for improving the prognosis of medulloblastoma in this population.METHODSA total of 67 pediatric cases of newly diagnosed medulloblastoma were included in this study. All of the children were treated at Xinhua Hospital between January 2007 and June 2013. The authors retrospectively analyzed the clinical data, treatment modalities, and outcome. The male-to-female ratio was 2:1, and the patients’ median age at diagnosis was 51.96 months (range 3.96–168.24 months). The median duration of follow-up was 32 months (range 3–70 months).RESULTSAt the most recent follow-up date, 31 patients (46%) were alive, 30 (45%) had died, and 6 (9%) had been lost to follow-up. The estimated 3-year overall survival and progression-free survival, based on Kaplan-Meier analysis, were 55.1% ± 6.4% and 45.6% ± 6.7%, respectively. Univariate analysis showed that standard-risk group (p = 0.009), postoperative radiotherapy (RT) combined with chemotherapy (p < 0.001), older age (≥ 3 years) at diagnosis (p = 0.010), gross-total resection (p = 0.012), annual family income higher than $3000 (p = 0.033), and living in urban areas (p = 0.008) were favorable prognostic factors. Multivariate analysis revealed that postoperative RT combined with chemotherapy was an independent prognostic factor (p < 0.001). The treatment abandonment rate in this cohort was 31% (21 of 67 cases).CONCLUSIONSThere was a large gap between the outcome of medulloblastoma in Chinese children and the outcome in Western children. Based on our data, treatment abandonment was the major cause of therapeutic failure. Parents’ misunderstanding of medulloblastoma played a major role in abandonment, followed by financial and transportation difficulties. Establishment of multidisciplinary treatment teams could improve the prognosis of medulloblastoma in Chinese children.
Lidar measurement of surface melt for a temperate Alpine glacier at the seasonal and hourly scales
Authors: Gabbud Chrystelle , Micheletti Natan , Lane Stuart N. 
Published: October 2015

AbstractThis study shows how a new generation of terrestrial laser scanners can be used to investigate glacier surface ablation and other elements of glacial hydrodynamics at exceptionally high spatial and temporal resolution. The study area is an Alpine valley glacier, Haut Glacier d’Arolla, Switzerland. Here we use an ultra-long-range lidar RIEGL VZ-6000 scanner, having a laser specifically designed for measurement of snow- and ice-cover surfaces. We focus on two timescales: seasonal and daily. Our results show that a near-infrared scanning laser system can provide high-precision elevation change and ablation data from long ranges, and over relatively large sections of the glacier surface. We use it to quantify spatial variations in the patterns of surface melt at the seasonal scale, as controlled by both aspect and differential debris cover. At the daily scale, we quantify the effects of ogive-related differences in ice surface debris content on spatial patterns of ablation. Daily scale measurements point to possible hydraulic jacking of the glacier associated with short-term water pressure rises. This latter demonstration shows that this type of lidar may be used to address subglacial hydrologic questions, in addition to motion and ablation measurements.
Responses of two understory herbs, Maianthemum canadense and Eurybia macrophylla, to experimental forest warming: Early emergence is the key to enhanced reproductive output
Authors: Jacques Marie‐Hélène , Lapointe Line , Rice Karen , Montgomery Rebecca A. , Stefanski Artur , Reich Peter B. 
Published: October 2015

PREMISE OF THE STUDY:Understory herbs might be the most sensitive plant form to global warming in deciduous forests, yet they have been little studied in the context of climate change.METHODS:A field experiment set up in Minnesota, United States simulated global warming in a forest setting and provided the opportunity to study the responses of Maianthemum canadense and Eurybia macrophylla in their natural environment in interaction with other components of the ecosystem. Effects of +1.7° and +3.4°C treatments on growth, reproduction, phenology, and gas exchange were evaluated along with treatment effects on light, water, and nutrient availability, potential drivers of herb responses.KEY RESULTS:Overall, growth and gas exchanges of these two species were modestly affected by warming. They emerged up to 16 (E. macrophylla) to 17 d (M. canadense) earlier in the heated plots than in control plots, supporting early‐season carbon gain under high light conditions before canopy closure. This additional carbon gain in spring likely supported reproduction. Eurybia macrophylla only flowered in the heated plots, and both species had some aspect of reproduction that was highest in the +1.7°C treatment. The reduced reproductive effort in the +3.4°C plots was likely due to reduced soil water availability, counteracting positive effects of warming.CONCLUSIONS:Global warming might improve fitness of herbaceous species in deciduous forests, mainly by advancing their spring emergence. However, other impacts of global warming such as drier soils in the summer might partly reduce the carbon gain associated with early emergence.
La fabuleuse histoire de l’indice des prix de détail en France
Authors: Touchelay Béatrice 
Published: October 2015

La « fabuleuse » histoire de l’indice des prix de détail en France est celle de l’évolution d’un marqueur social et politique témoin de l’augmentation de l’intervention de l’État dans la croissance économique et dans l’organisation sociale de la France contemporaine. Elle reflète aussi le développement de l’appareil public de statistique qui obtient progressivement les moyens de fournir des indicateurs de qualité. Avec la confirmation de l’inflation, apparue au début du siècle précédent puis accentuée par les deux guerres mondiales et par les reconstructions, la demande sociale et politique se porte, entre autres éléments, sur un indicateur pertinent de l’évolution du pouvoir d’achat des ouvriers. L’INSEE met au point cet indicateur et les autorités politiques s’en emparent. Le mécanisme de l’échelle mobile des salaires, le salaire minimum étant indexé sur l’indice des prix de détail de l’INSEE, est mis en œuvre entre la libération et le tournant de la rigueur en 1983. Il fait de l’INSEE et de son indicateur la cible de toutes les pressions et de toutes les critiques, qu’elles soient gouvernementales ou syndicales. La désindexation des salaires sur les prix et l’essoufflement de l’inflation désamorcent les tensions et correspondent aussi à la volonté politique d’assurer une plus forte emprise du secteur privé - sur la production de l’indicateur. Une page de l’histoire économique, sociale et politique de la France est tournée.
De la réparation individuelle à l’élaboration d’une cause collective
Authors: Fillion Emmanuelle , Torny Didier 
Published: October 2015

À partir du cas d’un médicament ayant entraîné des dommages sur de vastes populations – le distilbène – cet article propose une analyse sociologique des mobilisations de victimes sur la scène judiciaire. Elle est menée sous deux aspects : d’une part, le travail produit par les victimes avec et sur le droit, d’autre part, les effets en retour du droit sur les victimes, leurs collectifs et leur(s) cause(s), aux différentes étapes de l’engagement judiciaire et de la procédure. Nous mettons en lumière une tension permanente entre une expérience judiciaire singulière, marquée par l’isolement et l’opacité, et l’élaboration d’un « contentieux distilbène » qui joue un rôle déterminant dans la collectivisation et la publicisation d’une cause de santé publique.
Vemurafenib-related sterile scrotal abscess in a patient with BRAFV600K-mutant advanced melanoma mimicking distant metastasis
Authors: Marsico Jennifer Gibbons , Rodriguez Regulo , Müller Joachim , Jörger Markus 
Published: October 2015

Background:
Vemurafenib is a selective BRAF-inhibitor that has been approved for the use in patients with advanced BRAF-mutant melanoma. Major adverse events include skin rash, photosensitivity, pruritus, cutaneous squamous-cell carcinoma or keratoacanthoma.

Observation:
We present the case of a patient experiencing extensive sterile abscess of the scrotum after nine months of treatment with vemurafenib for oligometastatic (liver) BRAF-mutant melanoma. The scrotal lesion mimicked distant metastasis in a first round of clinical and radiological examinations, but was identified as sterile abscess after surgical exploration and complete excision. The patient went on to receive hemihepatectomy for melanoma supposedly confined to the liver, and continues receiving vemurafenib.

Conclusions:
We describe a remarkable case of probably vemurafenib-related sterile abscess. This adverse event is of substantial clinical relevance, as it mimicks metastatic melanoma and requires careful diagnostic evaluation and proper treatment to allow a favorable patient outcome.
A meta-analysis of Kang`ai injection combined with chemotherapy in the treatment of advanced non-small cell lung cancer
Authors: Wang Xueqian , Lin Hongsheng , Liyuan LV , Zhang Ying , Liu Jie , Liu Zhiyan , Shi Hong 
Published: October 2015

Objective:
The purpose of this study was to evaluate the Kang`ai injection combined with chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC) by meta-analysis.

Materials and Methods:
Electronic search of the Cochrane library, PubMed, EMBASE, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP), and Wanfang Database was conducted to collect appropriate studies about Kang`ai injection combined with chemotherapy versus chemotherapy alone in the treatment of NSCLC. All data were analyzed by using RevMan 5.2 software provided by Cochrane, which involved the odds ratio (OR) and 95% confidence intervals (95% CIs) calculated with fixed-effect models according to the heterogeneity test.

Results:
Eighteen studies were included in this meta-analysis. The meta-analysis showed that Kang`ai injection combined with chemotherapy could enhance the efficacy of the tumor response (OR = 1.51, 95% CI: 1.23-1.85, Z = 3.94, P < 0.0001), improve the quality of life (OR = 3.37, 95% CI: 2.71-4.20, Z = 10.86, P < 0.00001), alleviate the adverse reaction of digestive tract (OR = 0.42, 95% CI: 0.32-0.55, Z = 6.34, P < 0.00001) and reduce the risk of the bone marrow suppression (OR = 0.38, 95% CI: 0.29-0.49, Z = 7.37, P < 0.00001) compared with chemotherapy alone. Asymmetries were observed in funnel plots, which indicated an evidence of publication bias.

Conclusion:
Kang`ai injection combined with chemotherapy can enhance the short-term efficacy, improve the quality of life, and alleviate the chemotherapy-induced adverse reaction in the treatment of advanced NSCLC, although these results need to be further confirmed by more high-quality trials.
Effect of X-ray repair cross complementing group 1 polymorphisms on the efficacy of platinum-based chemotherapy in patients with nonsmall cell lung cancer
Authors: Fan Xiaohong , Xiu Qingyu 
Published: October 2015

Aims:
X-ray repair cross complementing group 1 (XRCC1) has been indicated to be correlated with the efficacy of platinum-based chemotherapy. But study results were still debatable. Thus, a meta-analysis was conducted.

Materials and Methods:
A literature search was performed using the PubMed, EMBASE, CNKI, with the databases being last accessed on November 24, 2014. Odds ratios with 95% confidence intervals were used to assess the strength of the association.

Results:
In this meta-analysis, we found that XRCC1 Arg194Trp polymorphism was significantly associated with the efficacy of platinum-based chemotherapy. However, XRCC1 Arg399Gln polymorphism showed no impact on the efficacy of platinum-based chemotherapy.

Conclusion:
This meta-analysis suggested that the XRCC1 Arg194Trp polymorphism may be associated with efficacy of platinum-based chemotherapy. Further studies with a larger sample size are needed to further assess this result.
Heegner Points on Cartan Non-split Curves
Authors: Kohen Daniel , Pacetti Ariel 
Published: October 2015

AbstractLet E/ℚ be an elliptic curve of conductor N, and let K be an imaginary quadratic field such that the root number of E/K is −1. Let be an order in K and assume that there exists an odd prime p such that p2 ∥ N, and p is inert in . Although there are no Heegner points on X0(N) attached to , in this article we construct such points on Cartan non-split curves. In order to do that, we give a method to compute Fourier expansions for forms on Cartan non-split curves, and prove that the constructed points form a Heegner system as in the classical case.
Tendances des précipitations mensuelles et quotidiennes dans le sud-est méditerranéen français (1950-51 / 1999-2000)
Authors: Norrant C. , Douguédroit A. 
Published: October 2015

Dans la perspective des scénarios pour les tendances des précipitations établis par les modèles pour la fin du XXIe siècle, nous nous sommes interrogées sur l’existence possible d’une amorce d’un changement pluviométrique dans la deuxième moitié du XXe siècle dans le sud-est méditerranéen français. En plus des précipitations totales mensuelles, nous avons étudié au pas de temps mensuel le nombre de jours de pluie, les précipitations quotidiennes moyennes et le niveau du 95ème centile entre 1950-51 et 1999-2000. Nous avons procédé à leurs régionalisations par des Analyses en Composantes Principales avec Rotation. Dans les trois régions obtenues seuls quelques mois montrent une diminution significative des totaux mensuels de pluies : octobre à l’est du Rhône, novembre dans la vallée du Rhône et mars à l’ouest du Rhône. Ces diminutions sont associées dans les deux premières régions à une diminution significative des moyennes quotidiennes de pluie et dans la dernière région à une diminution significative du nombre de jours de pluie. Parallèlement à cela, la part des précipitations supérieures au 95ème centile a augmenté au cours de la deuxième moitié du XXe siècle de part et d’autre du Rhône. Les diminutions significatives des précipitations sont en relation significative inverse avec les pressions de surface locales.
Energizing Occupation as the Center of Teaching and Learning
Authors: Hooper Barbara , Mitcham Maralynne D. , Taff Steven D. , Price Pollie , Krishnagiri Sheama , Bilics Andrea 
Published: October 2015

AbstractThe concept of occupation has experienced a renewal in the past 3 decades and is widely accepted as the core subject in occupational therapy. Professional education has a critical stewardship role in continually enhancing how occupation is taught and understood to enrich new occupational therapy practitioners' ability to grasp the purpose of the profession and reason clinically in complex practice environments. The authors discuss three questions that frame approaches educators can use to effectively centralize occupation in teaching and learning environments: (1) To what degree is a curriculum and its courses and class sessions subject centered? (2) To what degree do instructional processes create links to occupation? and (3) To what degree do instructional processes expose and promote complex ways of knowing needed for learning occupation? Keeping occupation in the foreground is important to facilitate new research, teaching methods, and curricular relevance to practice.
Fieldwork I Program Evaluation of Student Learning Using Goal Attainment Scaling
Authors: Chapleau Ann , Harrison Jennifer 
Published: October 2015

Abstract
This article describes a program evaluation of student learning during the Level I fieldwork experience of a master of science in occupational therapy program. We sought to determine the utility of Goal Attainment Scaling (GAS) as a measure of student learning. Over four semesters, from fall 2013 through fall 2014, 240 students completed goal attainment scales for an individualized learning goal for the semester. Using a quantitative pretest–posttest design, we found significant increases in levels of student learning goal attainment during Level I fieldwork. Qualitative data from exit surveys revealed high levels of satisfaction with the program, particularly related to the opportunity to learn a new way of envisioning and writing individualized goals. These findings support the use of GAS as an outcome measure of student learning during fieldwork.
Patient-Reported Outcomes and Outcome Predictors after Primary Total Hip Arthroplasty: Results from the Dresden Hip Surgery Registry
Authors: Haase Elisabeth , Kopkow Christian , Beyer Franziska , Lützner Jörg , Kirschner Stephan , Hartmann Albrecht , Schmitt Jochen , Günther Klaus-Peter 
Published: October 2015

Purpose To investigate response rates and predictors of treatment success in patients treated with total hip arthroplasty (THA). Methods A prospective register-based cohort study including all consecutive primary THAs was conducted ­between 01/2006-12/2011. Primary outcomes were changes in WOMAC, according to OMERACT-OARSI, and minimal important difference (MID) in quality of life (EQ-5D) between baseline and 6-month follow-up. Socioeconomic and clinical predictors on treatment success were analysed by bivariate/multivariate regression. Results The study population included 2,553 patients (mean age 60.8 years; 52.8% female) and 2,391 (93.7%) at follow-up. 2,194 (93.8%) (OMERACT-OARSI) and 2,131 (83.5%) (EQ-5D MID) patients were classified as responders. Predictors for treatment success vs treatment failure were not identified. Obese patients and patients living alone showed less pronounced, and patients with higher educational level more pronounced, improvements in the WOMAC at follow-up. Conclusions Treatment with THA leads to improvement in function, decline in pain and increase in quality of life in the vast majority of patients.
Total Hip Arthroplasty through a Direct Anterior Approach for Fused Hips
Authors: Tamaki Tatsuya , Oinuma Kazuhiro , Miura Yoko , Shiratsuchi Hideaki 
Published: October 2015

Introduction Conversion to total hip arthroplasty (THA) from a fused hip is a challenging procedure because of the technical difficulties involved. Here we report the surgical procedure and the early clinical outcome of conversion THA from a fused hip through a direct anterior approach. Methods 9 consecutive THAs following hip fusion were performed in 9 patients. Of these, 6 patients had undergone surgical hip fusion and 3 patients had nonsurgical fusion. Results The mean time interval between fusion and THA was 29.7 years. The mean follow-up period was 5.2 years. All THAs were performed using a direct anterior approach on a standard surgical table. The mean operative time was 68.7 minutes. The mean intraoperative blood loss was 377 g. All acetabular components were placed within Lewinnek's safe zone. The mean Japanese Orthopaedic Hip Score significantly improved from 54.0 to 73.2. One early anterior dislocation occurred and was treated conservatively. No revision surgery was required. Conclusions The direct anterior approach allows for an accurate and less invasive implantation of the total hip components.
Transmission of Hepatitis C Virus in Dialysis Units: A Systematic Review of Reports on Outbreaks
Authors: Fabrizi Fabrizio , Messa Piergiorgio 
Published: October 2015

Background Hepatitis C virus (HCV) outbreaks among patients on hemodialysis are still an important health concern all over the world. Aims We performed a systematic review of reports on HCV outbreaks within dialysis units of developed and less-developed countries (between 1992 and 2015) to evaluate risk factors and practices associated with patient-to-patient transmission of HCV in this setting. Methods The research was performed using the PubMed Database and the Outbreak Database; studies were selected according to the PRISMA algorithm. Inclusion criteria were established before the papers were retrieved in order to avoid selection biases. Results 36 papers reported on 45 outbreaks that involved 335 unique patients on maintenance hemodialysis; no fatal cases were detected. Nosocomial transmission of HCV was confirmed by phylogenetic analysis in most (n = 31; 69%) reports. Sharing contaminated hemodialysis machines and multidose vials (heparin or saline solution) was suggested responsible for HCV transmission in 8 (18%) and 6 (13%) outbreaks, respectively. Breaches in environmental cleaning and disinfection practices, and failures in medication preparation and administration practices was considered in 29 (65%) outbreaks; however, the exact mechanism of transmission of HCV could not be ascertained in each facility where an outbreak occurred. Conclusions Our systematic review of reports on hepatitis C virus outbreaks shows that, although the full extent of HCV transmission in dialysis units is unknown, outbreaks continue to occur. Full compliance to standard/specific infection control procedures and routine serologic screening for HCV antibody play a pivotal role for preventing the transmission of HCV within hemodialysis units.
Psychological Screening of Onco-Hematologic Inpatients: Distress Thermometer Administration
Authors: Bellè Marta , Muzzatti Barbara , Tomas Maddalena , Gherlinzoni Filippo 
Published: October 2015

Purpose The screening of psychological distress is a milestone in psycho-oncology. The National Comprehensive Cancer Network has established clinical guidelines for detecting and managing it and the Distress Thermometer (DT) was the recommended tool for the screening. Although its utility for oncologic patients has been reported frequently in the literature, less is known about hematologic patients. The present study involves a sample of onco-hematologic adult patients. Methods In the current study, we proposed the Distress Thermometer and the Problem List in a sample of hematologic inpatients at Ca’ Foncello Hospital, Treviso, Italy. We evaluated 102 patients, 61% male and 39% female, median age 59 years (range 18-78). Enrolled patients had acute leukemia (31%), multiple myeloma (31%), or lymphoma (31%). Results A total of 41.6% of the patients presented psychological distress, and the DT score was associated with neither sex nor diagnosis. The psychological distress was mild in 21.8%, moderate in 13.8%, and severe in 12.9% of the patients. Conclusions Our results were consistent with previous results regarding the validation process of DT in a large sample of Italian cancer patients.