bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial Integration in the Spanish Mackerel Market
Authors: García‐Enríquez Javier , Hualde Javier , Arteche Josu , Murillas‐Maza Arantza 
Published: May 2013

AbstractThis article analyses the potential links between regional first‐sale markets for mackerel in Spain using fractional cointegration techniques. The results indicate that this is not an integrated market, and we demonstrate that there are no links, at least in the long term, between any of Spain's five regional markets. This result has significant implications in policy terms, as local, regional and European authorities must take into account the need to apply distinct local policies.
Correlation of articular involvement, skin disfigurement and unemployment with depressive symptoms in patients with systemic sclerosis: a hospital sample
Authors: Tedeschini Enrico , Pingani Luca , Simoni Elena , Ferrari Daniela , Giubbarelli Cinzia , Giuggioli Dilia , Lumetti Federica , Rigatelli Marco , Ferri Clodoveo , Ferrari Silvia 
Published: May 2013

AbstractBackgroundSystemic sclerosis (SSc) is a connective tissue disease associated with increased functional impairment, body image distress due to skin lesions, and psychosocial comorbidity, particularly depression. Prevalence of depressive symptoms in SSc patients ranges from 36% to 65% and it contributes to the worsening of any aspect of the disease. The aim of this study was to investigate the prevalence and clinical and non‐clinical correlates of depressive symptoms in a sample of outpatients with SSc.MethodsSeventy‐eight consecutive SSc outpatients were recruited from February 2005 to July 2007. Socio‐demographic and SSc‐related clinical data were collected, including a modified Rodnan Skin Score, the Valentini Disease Activity Index and psycho‐metric assessment of disability and pain. Depressive symptoms were assessed using the Beck Depression Inventory (BDI). Two questions on perception of support from relatives and impact of disfigurements were also directly addressed to subjects.ResultsThe BDI mean score was 10.5 (± 8.3), with 36 subjects (46.2%) scoring above clinical significance. Unemployment, increased disability, pain, disease activity and articular involvement were significantly associated with more depressive symptoms. Older age, unemployment and more depressive symptoms were also related with complaints of disfigurements due to skin involvement.ConclusionsDepression is an influential prognostic factor in SSc. The present study contributes to the knowledge of the relationship between depression and clinical features routinely collected in rheumatology settings in order to develop a standardized assessment of psychosocial distress in routine rheumatologic procedures.
Pemetrexed plus carboplatin as adjuvant chemotherapy in patients with curative resected non‐squamous non‐small cell lung cancer
Authors: Zhang Liang , Ou Wei , Liu Qianwen , Li Ning , Liu Li , Wang Siyu 
Published: May 2013

AbstractBackgroundCisplatin‐based adjuvant chemotherapy provided a significant advantage in the overall survival (OS) of patients with stage II and III non‐small cell lung cancer (NSCLC). However, the compliance and toxicity in cisplatin‐based treatment were not always satisfactory. Pemetrexed plus carboplatin (PC) had better chemotherapy compliance and efficiency in advanced non‐squamous NSCLC patients. The aim of our study was to investigate the feasibility and efficacy of PC as adjuvant chemotherapy in patients with completely resected non‐squamous NSCLC.MethodsEighty‐two eligible non‐squamous NSCLC patients operated on with pathological stage II or IIIA were enrolled in this trial. Adjuvant chemotherapy was initiated between one and four weeks after surgery, and consisted of four cycles of pemetrexed (500 mg/m2) plus carboplatin (AUC = 5) every three weeks. The primary endpoint was the compliance of the regimen and the second endpoint was disease‐free survival (DFS).ResultsPatient demographics were median age 58 years (range 32 to 78) and gender ratio 68.3% male/31.7% female. Forty‐eight (58.5%) of the patients were at stage II, and the other thirty‐four (41.5%) patients were at stage IIIA. Seventy patients (85.4%) received four cycles of therapy over a 12‐week period. Reasons for discontinuing therapy included: patient's refusal (n = 10); severe adverse events (n = 1); and surgical complications (n = 1). The primary grade 3 to 4 adverse reaction was hematologic toxicity: neutropenia (13.4%); leucopenia (7.3%); anemia (3.7%); and thrombocytopenia (2.4%). Non‐hematological adverse events were mild. No treatment related deaths were observed. Median DFS for stage II and IIIA patients were 38.0 months (95% confidence interval (CI): 28.1 to 47.9 months) and 21.0 months (95%CI: 13.7 to 28.3 months), respectively.ConclusionAdjuvant PC chemotherapy was an acceptable regimen in resected non‐squamous NSCLC patients.
Gambling in Spain: update on experience, research and policy
Authors: Jiménez‐Murcia Susana , Fernández‐Aranda Fernando , Granero Roser , Menchón Jose Manuel 
Published: May 2013

AbstractAimsTo describe the current situation of gambling in Spain, sketching its history and discussing the regulations and legislation currently in force within the framework of the European Union (EU), and to review the epidemiology of gambling in Spain, the self‐help groups and professional treatments available, and their potential effectiveness.MethodsA systematic computerized search was performed in three databases (EMBASE, PubMed and PsychINFO, including articles and chapters) and the reference lists from previous reviews to obtain some of the most relevant studies published up to now on the topic of pathologic gambling in Spain.ResultsSimilar to other EU countries, Spain has a high prevalence of pathologic gambling, focused on specific culturally bounded types of gambling. Expenditure in online gaming has risen significantly in the last few years, prompting the Spanish government to draft new legislation to regulate gaming.ConclusionsThe gaming industry is expected to be one of the fastest growing sectors in Spain in the coming years owing to the rise of new technologies and the development of online gaming.
Simvastatin local drug delivery in smokers with chronic periodontitis: a randomized controlled clinical trial
Authors: Rao NS , Pradeep AR , Bajaj P , Kumari M , Naik SB 
Published: May 2013

AbstractBackgroundSimvastatin (SMV) is a specific competitive inhibitor of 3‐hydroxy‐2‐methyl‐glutaryl coenzyme A reductase. Statins have recently been shown to promote bone formation. This study was designed to investigate the effectiveness of SMV 1.2% in an indigenously prepared biodegradable controlled release gel as an adjunct to scaling and root planing (SRP) in the treatment of smokers with chronic periodontitis.MethodsForty patients were categorized into two treatment groups: SRP plus SMV 1.2% and SRP plus placebo. Clinical parameters were recorded at baseline and at 3, 6 and 9 months; they included modified sulcus bleeding index (mSBI), probing depth (PD) and clinical attachment level (CAL). At baseline, after 6 months and 9 months, radiologic assessment of intrabony defect (IBD) fill was done using computer‐aided software.ResultsMean probing depth reduction and mean clinical attachment level gain was greater in the SMV group than the placebo group at all visits. Furthermore, significantly greater mean percentage of bone fill was found in the SMV group (32.37 ± 10.23%) compared to the placebo (4.18 ± 5.39%).ConclusionsThere was a greater decrease in mSBI and PD and more CAL gain with significant IBD fill at sites treated with SRP plus locally delivered SMV in smokers with chronic periodontitis.
Assessing the impact of menopause on salivary flow and xerostomia
Authors: Minicucci EM , Pires RBC , Vieira RA , Miot HA , Sposto MR 
Published: May 2013

AbstractBackgroundThe aim of this study was to evaluate the symptoms of dry mouth and salivary flow in menarche and menopausal women.MethodsObjective and subjective assessment of salivary function were analysed by Xerostomia Inventory and Visual Analogue Scale questionnaire in menopausal and menarche women (control group). Salivary flow was evaluated by a chemical absorption stimulation test. Each subject provided three saliva samples: S1, non‐stimulated saliva; S2, saliva initially stimulated with two drops of citric acid 2.5%; and S3, saliva super‐stimulated with two drops of citric acid 2.5% every 30 seconds for two minutes.ResultsNo intergroup association was observed between Xerostomia Inventory and Visual Analogue Scale questionnaire. In both groups, the salivary flow was greatest at S3, followed by S2 and finally S1. Salivary flow was lower in the menopausal group compared to the control group only in S2 and S3.ConclusionsIn the menopausal group, the salivary flow showed reduction but without clinical symptoms of dry mouth. It is important to normalize salivary flow to prevent oral abnormalities and maintain oral health.
Partial luxation and displacement of tooth during treatment of malocclusion using light‐wire fixed appliances – therapeutic procedure
Authors: Malinowska‐Jedraszczyk A , Wozniak K 
Published: May 2013

AbstractFacial trauma sustained during an accident by a 17‐year‐old female patient who wore thin‐wire fixed appliances caused partial luxation and displacement of tooth 21. Because it was attached to a fixed appliance, the tooth did not lose contact with the socket, which significantly improved the prognosis. This study describes the method, course and result of the treatment carried out over a two‐year period after the trauma occurred.
Evaluation of air‐particle abrasion of Y‐TZPwith different particles using microstructural analysis
Authors: Turp V , Sen D , Tuncelli B , Goller G , Özcan M 
Published: May 2013

AbstractBackgroundThis study evaluated the effect of air‐particle abrasion with different particle sizes on the surface roughness and phase transformation of yttria‐stabilized tetragonal zirconia ceramics (Y‐TZP).MethodsEighty‐four Y‐TZPdiscs of 15 mm diameter and 1.0 mm thickness were fabricated. The samples were divided into four groups (n = 21): (1) air‐particle abrasion with 30 μm CoJet sand blast coating agent (CoJet, 3MESPE); (2) 50 μm Al2O3particles; (3) 110 μm Al2O3particles; and (4) 250 μm Al2O3particles. Each group was further divided into three subgroups each (n = 7) and treated for 5 seconds, 15 seconds and 30 seconds. Mean surface roughness was determined using a profilometer. The surfaces were analysed with a scanning electron microscope.XRDanalysis was employed and the relative amount of the monoclinic phase was calculated. The results were statistically analysed by two‐way analysis of variance (ANOVA, p < 0.05).ResultsAir‐particle abrasion with 250 μm Al2O3particles for 30 seconds had the highest surface roughness (p < 0.001) and a significantly higher amount of monoclinic phase compared to air‐particle abrasion with 30 μm, 50 μm and 110 μm particles (p < 0.001).ConclusionsDuration and particle size of air‐particle abrasion affects the roughness and phase transformation of Y‐TZP. Longer treatment times with larger particles may result in degradation of material.
Genetic diversity of Vietnamese domestic chicken populations as decision‐making support for conservation strategies
Authors: Pham M. H. , Berthouly‐Salazar C. , Tran X. H. , Chang W. H. , Crooijmans R. P. M. A. , Lin D. Y. , Hoang V. T. , Lee Y. P. , Tixier‐Boichard M. , Chen C. F. 
Published: May 2013

SummaryThe aims of this study were to assess the genetic diversity of 17 populations of Vietnamese local chickens (VNN) and one Red Jungle Fowl population, together with six chicken populations of Chinese origin (CNO), and to provide priorities supporting the conservation of genetic resources using 20 microsatellites. Consequently, the VNN populations exhibited a higher diversity than did CNO populations in terms of number of alleles but showed a slightly lower observed heterozygosity. The VNN populations showed in total seven private alleles, whereas no CNO private alleles were found. The expected heterozygosity of 0.576 in the VNN populations was higher than the observed heterozygosity of 0.490, leading to heterozygote deficiency within populations. This issue could be partly explained by the Wahlund effect due to fragmentation of several populations between chicken flocks. Molecular analysis of variance showed that most of genetic variation was found within VNN populations. The Bayesian clustering analysis showed that VNN and CNO chickens were separated into two distinct groups with little evidence for gene flow between them. Among the 24 populations, 13 were successfully assigned to their own cluster, whereas the structuring was not clear for the remaining 11 chicken populations. The contributions of 24 populations to the total genetic diversity were mostly consistent across two approaches, taking into account the within‐ and between‐populations genetic diversity and allelic richness. The black H'mong, Lien Minh, Luong Phuong and Red Jungle Fowl were ranked with the highest priorities for conservation according to Caballero and Toro's and Petit's approaches. In conclusion, a national strategy needs to be set up for Vietnamese chicken populations, with three main components: conservation of high‐priority breeds, within‐breed management with animal exchanges between flocks to avoid Wahlund effect and monitoring of inbreeding rate.
Subcutaneous and gonadal adipose tissue transcriptome differences in lean and obese female dogs
Authors: Grant Ryan W. , Vester Boler Brittany M. , Ridge Tonya K. , Graves Thomas K. , Swanson Kelly S. 
Published: May 2013

SummaryCanine obesity leads to shortened life span and increased disease incidence. Adipose tissue depots are known to have unique metabolic and gene expression profiles in rodents and humans, but few comparisons of depot gene expression have been performed in the dog. Using microarray technology, our objective was to identify differentially expressed genes and enriched functional pathways between subcutaneous and gonadal adipose of lean and obese dogs to better understand the pathogenesis of obesity in the dog. Because no depot × body weight status interactions were identified in the microarray data, depot differences were the primary focus. A total of 946 and 703 transcripts were differentially expressed (FDRP < 0.05) between gonadal and subcutaneous adipose tissue in obese and lean dogs respectively. Of the adipose depot‐specific differences in gene expression, 162 were present in both lean and obese dogs, with the majority (85%) expressed in the same direction. Both lean and obese dog gene lists had enrichment of the complement and coagulation cascade and systemic lupus erythematosus pathways. Obese dogs had enrichment of lysosome, extracellular matrix–receptor interaction, renin–angiotensin system and hematopoietic cell lineage pathways. Lean dogs had enrichment of glutathione metabolism and synthesis and degradation of ketone bodies. We have identified a core set of genes differentially expressed between subcutaneous and gonadal adipose tissue in dogs regardless of body weight. These genes contribute to depot‐specific differences in immune function, extracellular matrix remodeling and lysosomal function and may contribute to the physiological differences noted between depots.
Associations between lifestyles and neutrophil‐lymphocyte and platelet‐lymphocyte ratios in colorectal cancer
Authors: Hong Chuyuan , Wei Yisheng , Jiang Jianxin , Zhao Chuxiong , Liang Guojian , Wang Guoqiang , Yang Hui 
Published: May 2013

AbstractAimsTo explore the etiology of the neutrophil‐lymphocyte ratio (NLR) and platelet‐lymphocyte ratio (PLR) abnormalities in colorectal cancer.MethodsIn total, 230 patients with histopathologically confirmed colorectal cancer from August 2009 to August 2011 were recruited to our study. The associations between lifestyles (smoking, alcohol and pickled food consumption) and pretreatment NLR and PLR were estimated using the Kruskal–Wallis tests and linear regression model.ResultsThe Kruskal–Wallis test showed a significant association between pickled food intake and pretreatment NLR but not PLR (P = 0.002, 0.057, respectively). Pairwise comparisons showed that, compared with those with a moderately frequent (2–3 times/week) and an infrequent (≤ once a week) intake of pickled food, high frequency (≥ four times/week) consumption of pickled food had a higher pretreatment NLR (P = 0.01, 0.007, respectively). Multivariate linear regression analysis showed pretreatment NLR increased significantly in high frequency (≥ four times/week) consumption of pickled food (P < 0.0001). No association between other lifestyle factors and pretreatment PLR was found.ConclusionsA higher frequency intake of pickled food possibly contributes to higher NLR, which may reflect a systemic inflammatory response in colorectal cancer.
Influence of ABO blood group and Rhesus factor on breast cancer risk: A meta‐analysis of 9665 breast cancer patients and 244 768 controls
Authors: Miao Su‐Yu , Zhou Wenbin , Chen Ling , Wang Shui , Liu Xiao‐An 
Published: May 2013

AbstractAimBlood group is an important risk factor for some malignancies, including pancreatic and stomach cancer. However, it is unclear whether the risk of breast cancer is higher in any specific ABO blood type.MethodsWe searched the electronic database of PubMed, EMBASE, China National Knowledge Infrastructure and the VIP Chinese Journal of Science and Technology for case‐control studies about blood type and breast cancer incidence, and a meta‐analysis was conducted.ResultsFourteen studies were eligible for assessment on the association of breast cancer with different blood types, including 9665 breast cancer patients and 244 768 controls. Relative to blood type O, women with blood type A (odds ratio (OR) = 1.115, 95% confidence interval (CI) 0.992–1.254), B (OR = 0.983, 95% CI 0.915–1.056) and AB (OR = 1.042, 95% CI 0.881–1.231) had the same breast cancer risk. The risk for women with Rhesus‐positive (Rh+) was the same as those with Rh‐negative (Rh‐) (OR = 0.948, 95% CI 0.667–1.348). Among Caucasians, the OR of blood type A was 1.066 (95% CI, 1.001–1.134, P = 0.522 for heterogeneity).ConclusionThis meta‐analysis suggests Caucasians with blood type A may have a higher risk of breast cancer than other Caucasians. No association was found in any other blood type or any other population. Similarly, the Rh factor had no association with the risk of breast cancer.
The impact of type 2 diabetes mellitus on mortality in hospitalized female cancer patients in Taiwan
Authors: Chen Jeng‐Yeou , Chiou Wen‐Ko , Chou Wei‐Ying , Lin Jen‐Der 
Published: May 2013

AbstractIntroductionThe goal of this study was to determine the relationships among type 2 diabetes mellitus (DM), specific cancer histological types and mortality in hospitalized women.MethodsPatients over 19 years of age were included if the indication for hospital admission was a diagnosis of type 2 DM or a malignancy. In total, 67 660 female patients with a mean age 62.76 ± 14.48 years were enrolled. These patients were categorized into the following three groups: patients with cancer but without type 2 DM (group A); patients with cancer and type 2 DM (group B) and patients with type 2 DM but without cancer (group C). Attributable fractions (AF) were calculated as ([hazard ratio − 1]/hazard ratio) × 100 to evaluate the impact of type 2 DM on mortality for specific cancers.ResultsOf the study participants, 37 204 (55%) were diagnosed with type 2 DM. The patients were categorized as follows: group A, 30 456 patients; group B, 5992 patients and group C, 31 212 patients. Group B patients had high frequencies of pancreatic, liver and renal cancers and low frequencies of thyroid, breast and ovarian cancers. Of the 36 448 cancer patients, 2906 (8%) died. The mortality rate in group B (10 %) was significantly higher than that in groups A and C. Type 2 DM was associated with increased mortality and AF for thyroid, nasopharyngeal, urinary tract, ovarian, breast and cervical cancers (hazard ratio over 1.50).ConclusionThe incidence of type 2 DM in patients with different histological types of cancer varied widely, ranging from 8–34%. Among the cancer patients, type 2 DM had a significantly greater impact on the mortality rates of patients with cancers associated with relatively low mortality.
Multidrug resistant miliary tuberculosis during infliximab therapy despite tuberculosis screening
Authors: Gin Alexander , Dolianitis Con 
Published: May 2013

AbstractWe describe an unusual case of multidrug‐resistant miliary tuberculosis diagnosed 9 months after the commencement of infliximab treatment for psoriasis despite negative pretreatment tuberculosis screening, including chest X‐ray and interferon‐gamma release assay. After 4 months' treatment with amikacin, ethambutol, pyrazinamide and moxifloxacin, infliximab was restarted with concomitant anti‐TB medications. No recurrence of tuberculosis has been detected 12 months after recommencing infliximab.
Elevated protein carbonyl and HIF‐1α levels in eyes with proliferative diabetic retinopathy
Authors: Loukovaara Sirpa , Koivunen Peppi , Inglés Marta , Escobar Javier , Vento Maximo , Andersson Sture 
Published: May 2013

Abstract.Purpose:  To evaluate the role of protein carbonyls and hypoxia inducible factor‐1α (HIF‐1α) in diabetic eyes with proliferative diabetic retinopathy (PDR).Methods:  Prospective consecutive controlled observational study was performed. Vitreous samples were collected at the start of the 3‐ppp vitrectomy. Protein carbonylation analysis was performed by Western blotting with antibody against 2,4‐Dinitrophenol (anti‐DNP), following derivatization of protein carbonyls with 2,4 Dinitrophenylhydrazine (DNHP). Protein carbonylation was quantified by scanning densitometry analysis and relativized to the total amount of protein into the ponceau staining of membranes. Vitreous HIF‐1 α was determined with ELISA in a subgroup of the samples. Thirty‐one eyes were operated due to PDR (study group). Of the 189 controls, 39 had nonproliferative diabetic retinopathy (non‐PDR), 111 retinal detachment (RD) and 39 macular hole/pucker (MH).Results:  Comparison of eyes with PDR with controls revealed that the mean vitreous concentrations of protein carbonyls were significantly higher in the eyes affected with PDR being 242 ± 130 (SD) compared with non‐PDR controls 180 ± 142, nondiabetic eyes affected with RD 175 ± 131 and MH/pucker 140 ± 95 (p = 0.008, one‐way anova). Mean HIF‐1α values were higher in eyes with PDR compared with controls (RD, MH/pucker); the values being 0.53 ± 0.34 (SEM; n = 4) and 0.13 ± 0.04 (SEM; n = 19), respectively (p = 0.009).Conclusions:  Protein carbonyl and HIF‐1 α levels were significantly increased in the vitreous fluid of surgically treated eyes with PDR. Our findings suggest an association between increased intravitreal levels of protein carbonyls and the pathogenesis of PDR.