bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAM210A: An emerging regulator of mitochondrial homeostasis
Authors: Wang Yubo , Yue Feng 
Published: August 2024

AbstractMitochondrial homeostasis serves as a cornerstone of cellular function, orchestrating a delicate balance between energy production, redox status, and cellular signaling transduction. This equilibrium involves a myriad of interconnected processes, including mitochondrial dynamics, quality control mechanisms, and biogenesis and degradation. Perturbations in mitochondrial homeostasis have been implicated in a wide range of diseases, including neurodegenerative diseases, metabolic syndromes, and aging‐related disorders. In the past decades, the discovery of numerous mitochondrial proteins and signaling has led to a more complete understanding of the intricate mechanisms underlying mitochondrial homeostasis. Recent studies have revealed that Family with sequence similarity 210 member A (FAM210A) is a novel nuclear‐encoded mitochondrial protein involved in multiple aspects of mitochondrial homeostasis, including mitochondrial quality control, dynamics, cristae remodeling, metabolism, and proteostasis. Here, we review the function and physiological role of FAM210A in cellular and organismal health. This review discusses how FAM210A acts as a regulator on mitochondrial inner membrane to coordinate mitochondrial dynamics and metabolism.
In through the out door: A loop‐binding‐first model for topological cohesin loading
Authors: Rhind Nicholas 
Published: August 2024

AbstractCohesin is a ring‐shaped complex that is loaded on DNA in two different conformations. In one conformation, it forms loops to organize the interphase genome; in the other, it topologically encircles sibling chromosomes to facilitate homologous recombination and to establish the cohesion that is required for orderly segregation during mitosis. How, and even if, these two loading conformation are related is unclear. Here, I propose that loop binding is a required first step for topological binding. This loop‐binding‐first model integrates the known information about the two loading mechanisms, explains genetic requirements for the two and explains how topological loading evolved from loop binding.
Fly or Fry: Understanding the dynamics of brand hate and consumer resilience in the airline and restaurant industries
Authors: Mushtaq Fakhra Malik , Hamzah Zalfa Laili , Ghazali Ezlika M. 
Published: August 2024

AbstractThis study addresses a critical gap in the literature on the consumer–brand relationship by focusing on the under‐investigated concept of attitudinal and behavioural brand hate. This study goes beyond such common determinants as negative experiences and unfair pricing, introducing employee incivility and service quality as overlooked, but significant, antecedents. Employing structural equation modelling, a sample of 593 participants from the airline and restaurant industries was examined. The findings reveal that brand hate significantly impacts brand opposition and emotional forgiveness. Importantly, consumer resilience moderates these relationships, mitigating the negative effects of brand hate. Moreover, the study finds industry‐specific variations in the triggers and outcomes of brand hate, suggesting the need for tailored managerial strategies. The study extends the consumer–brand relationship literature by highlighting new research avenues and making significant contributions. Theoretically, it validates affective event theory and personality characteristics' role in buffering brand hate. In addition, this study carries implications for policymakers and managers to understand the multifaceted nature of brand hate, develop effective strategies to mitigate the negative effects of service failures and build stronger consumer–brand relationships. Furthermore, these insights facilitate the creation of tailored approaches that consider industry‐specific characteristics, thus helping to prevent the harmful impact of brand hate.
Green Synthesis of Pleurotus Eryngii‐Derived Nanomaterials for Phytopathogen Control
Authors: Acay Hilal , Güler Güney İnci , Yildirim Ayfer , Derviş Sibel , Dereli Elif 
Published: August 2024

AbstractGrowing concerns over the human health and environmental impacts of conventional fungicides, coupled with the escalating challenge of microbial resistance, have fueled the search for sustainable biocontrol strategies against plant pathogens. This study reports, for the first time, the green synthesis and characterization of a novel, eco‐friendly nanomaterial, designated Pleurotus eryngii‐Lecithin‐Chitosan Nanomaterial (PEELCN), derived from P. eryngii extract (PEE), lecithin (L), and chitosan (C). The structural attributes of PEELCN were elucidated using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), X‐ray Diffraction (XRD), and zeta potential measurements, confirming the successful formation of a stable and uniform nanostructure. The antifungal activity of PEELCN, and PEE, was assessed against five economically important phytopathogenic fungi: Neoscytalidium dimidiatum, Alternaria alternata, Verticillium dahliae, Bipolaris sorokiniana, and Fusarium oxysporum. Both PEE and PEELCN exhibited significant inhibitory effects on the mycelial growth of V. dahliae, B. sorokiniana, and N. dimidiatum, with varying degrees of efficacy. The differential antifungal activity suggests a species‐specific mode of action. The findings highlight the promising potential of PEELCN as a sustainable, biocompatible, and cost‐effective nanofungicide for the management of plant diseases, with the potential for development into a commercially viable biofungicide for sustainable agriculture.
Automated Optimization of the Synthesis of Alkyl Arenesulfonates in an Undivided Electrochemical Flow Cell
Authors: Hielscher Maximilian M. , Schneider Johannes , Lohmann Alexander H. J. , Waldvogel Siegfried R. 
Published: August 2024

AbstractThe necessary separation of anodic and cathodic compartments in the electrochemical multicomponent synthesis of alkyl arenesulfonates in batch was overcome by the transfer of this reaction in an undivided electrochemical flow cell. The yield was increased from an initial 23 % to 67 % by optimization using Design of Experiments (DoE). The experiments were carried out using an automated experimental flow electrolysis setup controlled by the automation software LABS (Laboratory Automation and Batch Scheduling), an open‐source software that allows to plan and conduct experiments with an arbitrary, freely selectable experimental setup. The automated experimental setup turned out to be stable and provides reproducible results. In total, 6 examples are demonstrated with isolated yields up to 81 %. In addition, the robust scalability of the electrochemical reaction was demonstrated in a 10‐fold scale‐up.
Acid mine drainage: the link between melting permafrost and heavy metals in mountain lake
Authors: Spitzer Philipp , Reichmann Eva , Tassoti Sebastian 
Published: August 2024

AbstractSchmelzender Permafrost und der Rückgang von Gletschereis können zu einer Erhöhung der Schwermetallkonzentration in Gebirgsbächen und Seen führen. Dies ist besonders in Regionen mit sulfidhaltigem Grundgestein wie Pyrit zu beobachten. Durch Acid Mine Drainage (AMD) wird der pH‐Wert der Gebirgsbäche gesenkt. Schwermetalle, die unter normalen Bedingungen gebunden sind, werden bei niedrigem pH‐Wert löslich und erhöhen die Konzentration an Schwermetallionen im Wasser. Die hier vorgestellten Modellversuche für den Chemieunterricht demonstrieren die geringen Pufferfähigkeiten von Gletscherwasser und die Versauerung durch Pyritoxidation, sowie die dadurch hervorgerufene Freisetzung von Schwermetallen am Beispiel von Kupfer. Die Experimente sind so konzipiert, dass sie im Unterricht leicht eingesetzt werden können. Zusätzlich erfolgt die Einbettung in eine digitale Lernumgebung mit VR‐Option, um Lernenden zumindest einen virtuellen Zugang zu Gletscherlandschaften zu ermöglichen.
Synthesis of Ag Nanowires with High Aspect Ratio for Highly Sensitive Flexible Strain Sensor
Authors: Qi Xue , Lv Hao , Wang Yuxin , Ye Yang , Wang Peike , Yin Ao , Luo Jingjing , Ren Zhongqi , Liu Haipeng , Liu Jiang , Yu Suzhu , Wei Jun 
Published: August 2024

AbstractIn recent years, the research and development of various flexible wearable devices have rapidly advanced due to the continuous introduction of flexible electronic product. These devices have found applications in health monitoring, cardiovascularcare, internal and external workload, and more.Flexible sensors, being a vital component of flexible devices, determine the functionalities and performance capabilities of the devices. Metal nanomaterials, especially silver nanowires, are widely used in flexible sensors in past research due to their great advantages in flexibility and sensitivity. In this work, Silver nanowires with aspect ratios of 600, 1000, and 1400 were synthesized by adjusting the synergy of Br‐ and Cl‐, along with other process parameters, leading to an improved production efficiency of silver nanowires.The stability of the conductive network is enhanced when the aspect ratio of silver nanowires is 1000 and 1400.The sensor demonstrated high sensitivity at high strain, along with an extended strain range.Moreover, it was observed that increasing the aspect ratio of silver nanowires led to a more stable conductive network, thus enhancing the sensor's stability with over 10000 stretching cycles. under the appropriate deposition density, silver nanowires with aspect ratio of 600 have high sensitivity to low strain, and silver nanowires with aspect ratio of 1400 have high sensitivity to high strain, up to 247.3. Introducing microstructures on the surface of PDMS resulted in an increased maximum sensitivity of the sensor with decreasing microstructure size, reaching a maximum sensitivity of 322.2.
The Impact Message Inventory‐Circumplex (IMI‐C): Exploring the Aversiveness Component of Therapists' Covert Reactions to Patients' Interpersonal Communications
Authors: Hafkenscheid Anton 
Published: August 2024

ABSTRACTThe Impact Message Inventory‐Circumplex (IMI‐C) is a two‐dimensional measure of patient‐induced countertransference. Surprisingly, in a replication study of its circumplex structure, Hafkenscheid and Timmerman could retrieve a third dimension, in addition to the basic dimensions of Affiliation and Control. They tentatively interpreted this preliminary third dimension as representing ‘reactance’ (oppositional and uncooperative patient behaviours), with ‘active’ and ‘passive’ as polarities. This provisional interpretation was no more than plausible and was partly speculative. Therefore, a more systematic empirical approach to the meaning embedded in the third dimension is required. The present empirical study tests the hypothesis that the preliminary third dimension might represent aversiveness rather than reactance. A panel of IMI‐C users (N = 100) independently judged all 56 items of the instrument in terms of the general (i.e., without taking a specific patient in mind) emotional undertone enclosed in the item formulations using a forced choice three point scale format: ‘positive emotional undertone’ (+), ‘neutral’ (o) and negative (aversive) undertone (−). Overall, IMI‐C users appeared to evaluate the formulations of items constituting the preliminary third dimension as intrinsically more aversive (negative emotional connotation), compared to the group of IMI‐C items not included in this preliminary third dimension. However, the original octants of the IMI‐C could be discriminated in terms of aversiveness as well. Anyhow, clinical interpretations of IMI‐C profiles may benefit from an examination of the aversiveness component, enclosed within the items and octants themselves, irrespective of the specific patients judged with the instrument.
Scaffolding geography's conceptual ways of thinking using ‘semantic waves’
Authors: Vernon Esther , Dunphy Alison 
Published: August 2024

AbstractThis paper discusses the application of Karl Maton's notion of ‘semantic waves’ to the teaching of geography at the post‐16 phase (A‐level) in England. Drawing on evidence generated through a 2‐year close‐to‐practice case study, it illustrates its potential as a scaffold in two ways. Firstly, one that can help teachers face both ways: Towards their subject discipline, to see it in more naïve forms, and towards their novice students, to make that form explicit and thus accessible to them. Such a deliberative or hermeneutic orientation stands in sharp contrast to the atomistic mode of the technicist orientation to knowledge dominant in English education. Secondly, as a scaffold that can provide a visual language for students which makes explicit the implicit relationship between different components of an essay, and in this sense, helps scaffold for a more relational mode of thinking about the geography itself. Interviews with students suggested semantic waves was: (i) a practical but not a prescriptive tool, (ii) a framework that could extend their thinking and (iii) a scaffold that connects knowledge with essay writing. It appeared to be a useful tool to bring the geographical knowledge and its complexity to the fore by aiding metacognitive thought.
Elevating optical networks: Machine learning approach for optimal resource scheduling and performance boost
Authors: S.S. Neetha Kala , Jain Aaditya , Bhatt Rahul , Sinha Sanjay Kumar , Saraswat Pankaj , Prabhakaran  
Published: August 2024

SummaryThe increasing demand for massaging networks that are stable and quick needs reevaluations of standard optical networking administration strategies. To improve the efficacy of optical networks by integrating machine learning (ML) approach for the best resource scheduling, this research presents an innovative dynamic block widow optimized random forest (DBWO‐RF) strategy. To implement the DBWO‐driven resource allocation method in accordance with the categorization and clustering findings, the RF method is incorporated with the software defined optical to achieve channel quality assessment after successfully clustering employs the RF approach to achieve channel quality assessment after successfully clustering traffic patterns using the fuzzy C‐means (FCM) algorithm. To lessen the likelihood of blocking, the fragmentation‐function‐fit (FFF) algorithm was provided and the findings indicate that this approach possesses a reduced blocking risk. Using multiple approaches to modulation for various channel quality, the suggested resource allocation system leverages the DBWO approach to distribute the necessary resources based on various “traffic flow (TF)” clustering findings. The examination's outcomes demonstrate that, compared to other techniques under various given load levels, the present study has a reduced blocking risk, a sufficient complexity degree and greater effectiveness in the utilization of spectrum resources.
Forest defoliation by an invasive outbreak insect: Catastrophic consequences for a charismatic mega moth
Authors: Lindroth Richard L. , Zierden Mark R. , Morrow Clay J. , Fernandez Patricia C. 
Published: August 2024

AbstractEarth is now experiencing declines in insect abundance and diversity unparalleled in human history. The drivers underlying those declines are many, complex, and incompletely known. Here, using a natural experiment, we report the first test of the hypothesis that forest defoliation by an invasive outbreak insect compromises the fitness of a native insect via damage‐induced increases in toxicity of the forest canopy. We demonstrate that defoliation by the invasive spongy moth (Lymantria dispar) elicits an average 8.4‐fold increase in foliar defense expression among aspen (Populus tremuloides) genotypes. In turn, elevated defense dramatically reduces survivorship, feeding, and growth of a charismatic mega moth (Anthereae polyphemus). This work suggests that changes to the phytochemical landscape of forests, mediated by invasive outbreak insects, are likely to negatively impact native insects, with potential repercussions for community diversity and ecosystem function across expansive scales.
Predicting the potential distribution of Taxus cuspidata in northeastern China based on the ensemble model
Authors: Chang Baoliang , Huang Chen , Chen Bingming , Wang Ziwen , He Xingyuan , Chen Wei , Huang Yanqing , Zhang Yue , Yu Shuai 
Published: August 2024

AbstractClimate change is poised to exert a significant impact on species distribution in the future, and Taxus cuspidata as an endangered species is no exception. Predicting the potential distribution of T. cuspidata is essential for decision‐makers to develop conservation policies and explicitly implement conservation measures. In this study, a combined model was employed to predict potentially suitable habitats for T. cuspidata based on extant data of T. cuspidata distributions in northeastern China. Our findings suggest that mean diurnal range (bio2) and isothermality (bio3) were identified as dominant factors influencing T. cuspidata distribution. Under future climate scenarios, suitable habitat areas increased only in the SSP126 scenario in the 2070s, declining in all other scenarios. In all climate scenarios, the centroid of suitable habitats ultimately shows a trend in northward movement. Decreases in suitable habitat predominantly occurred in Yanbian Korean Autonomous Prefecture, Baishan city, and Tonghua city. Overall, this study highlights a projected habitat reduction due to climate change. Recommendations entail the strategic establishment of nature reserves and the implementation of initiatives aimed at population replenishment.
Diaminomethylation of Pyrazoles
Authors: Koidan Georgyi , Zahorulko Serhii , Hurieva Anastasiia , Shishkina Svitlana , Rusanov Eduard B. , Kostyuk Aleksandr 
Published: August 2024

AbstractWe studied the reaction of N‐alkyl(aryl)pyrazoles with silylformamidine 1 that exists in an equilibrium with its carbene form via migration of the trimethylsilyl group from the carbon to nitrogen atom. The carbene insertion proceeded at the C−H group in 5th position. N‐alkyl(aryl)pyrazoles featuring substituents such as Br, CN and NO2 group reacted readily affording the corresponding aminals. This approach allowed us to synthesize pyrazole dialdehyde and phosphine featuring a vicinal aldehyde group. The reaction does not require any catalyst. The insertion position was unambiguously confirmed by X‐ray analysis of an aminal and a set of derivatives. Aminals hydrolysis afforded the corresponding pyrazole carbaldehydes. Methanolysis of the aminals gave N‐methylimines of the pyrazolecarbaldehydes. Highly acidic nitro pyrazole instead of the insertion underwent silylation in 5th position.
The effect of astaxanthin after varicocele surgery on antioxidant status and semen quality in infertile men: A triple‐blind randomized clinical trial
Authors: Ayub Mohammed Salih Shimal , Jabarpour Masoome , Sedighi Gilani Mohammad Ali , Sajadi Hesamoddin , Saedi Marghmaleki Mojtaba , Shabani Nashtaei Maryam , Salem Maryam , Amidi Fardin 
Published: August 2024

AbstractVaricocele (VC) is widely recognized as a prevalent etiological factor contributing to male infertility. It has been established that the generation of reactive oxygen species (ROS) plays a significant role in the progression and development of VC. Antioxidants may regulate ROS levels in these patients. Astaxanthin (ASX) is a carotenoid compound with notable antioxidant and anti‐inflammatory characteristics. The current study postulated that the administration of ASX following varicocelectomy (VCT) could potentially enhance antioxidant status and semen quality in these patients. A total of 40 infertile males with clinical VC and abnormal semen analyses were randomly assigned to take part in the current trial. For 3 months following surgery, the intervention group took ASX (6 mg/day) while the control group received a placebo. After intervention, semen parameters, antioxidant status, and pro‐inflammatory cytokines were compared between the two groups. Regarding semen parameters, antioxidant treatment led to a significant improvement in total and progressive motility in the treatment group (p < 0.05). Additionally, ASX led to a considerable increase in the expression levels of NRF2, Keap1, SOD2, SOD3, and BCL2, though the enhancement in the expression level of SOD3 was not statistically significant (p > .05). However, ASX significantly decreased the BAX expression level (p < .05). Even though the level of total antioxidant capacity (TAC) of seminal fluid (SF) increased significantly in the treatment group (p < .05), the level of total oxidative stress (TOS) in SF did not differ substantially between treatment and control groups (p > .05). Based on inflammatory factors in SF, ASX led to a considerable reduction in levels of TNF‐α, IL‐1β, and IL‐6 (p < .05). Our findings demonstrated that ASX treatment provides an important contribution to VCT outcomes by modulating antioxidant status and pro‐inflammatory cytokines. Our results indicated that ASX may be beneficial as an adjuvant therapy for infertile men following VCT.
The invisible city: The mundane biogeographies of urban microbial ecologies
Authors: Bradshaw Aaron 
Published: August 2024

AbstractMore‐than‐human, multispecies and animal geographic accounts of the city have tended to focus on large, charismatic and wild organisms, to the detriment of spatially invisible other‐than‐humans that are central to urban reproduction. At the same time, urban microbial geographies have foregrounded embodied interactions between humans and microorganisms, whether they are symbiotic or pathogenic, often marginalising the material contributions of extracorporeal microbiomes to the urban fabric. Building from these two blindspots, this article focuses on microbial ecologies that live constitutively outside of (other‐than‐)human bodies and which are intimately caught up in the metabolic intensities and infrastructural environments of the urban realm. There are two key aims: (1) to explore different forms of urban microbial ecologies and (2) to examine their relationships with urban infrastructures and reproduction. My disciplinary lenses are animal geography, microbe studies and urban ecology and my case studies are focused on urban water metabolism. Thus, based on empirical fieldwork on the urban River Lea in East London and supplemented by scientific literature and technical documents, I analyse three urban microbial ecologies that correspond to the urban realms’ ‘extended microbiomes’: those involved in slow sand filtration for the treatment of drinkable water, those involved in sewage treatment via the activated sludge process and those emerging and evolving in disused urban canal infrastructure. These processes spatially manage microbial growth and modulate the distribution of different forms of microbial agency with important effects for the smooth functioning of urban water metabolism. I suggest these ecologies correspond to the ‘spaces' of microbes in the city, and characterise a mundane system of repetition and regulation. However, microbes continue to assert their agency within the spaces of urban water metabolism, create their own places and worlds and highlight a more‐than‐human contingency and indeterminacy at the heart of urban reproduction.