bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modular Construction of Topologically Complex Polycyclic Acetals by Tether‐Controlled Domino Reactions
Authors: Castillo Rafael R. , Abet Valentina , Aquino Maurizio , Gandara Zoila , Retailleau Pascal , Arseniyadis Siméon 
Published: February 2013

AbstractLead tetraacetate mediated oxidative cleavage of octalin‐diols (1 and 1′), tethered by variously substituted arenes placed at the angular position (C11), show switchable regioselectivity effects. A highly selective set of regiochemical outcomes can be achieved, producing a range of polycyclic acetals through competing domino paths (A–E). The modular complexity inherent in the type‐1 domino precursors is derived from the C11 configuration, where the course of ring‐forming processes is controlled from the chirality at a remote stereocenter (C11). For methylene‐tethered type‐1′ precursors, the regiochemical outcome is mainly determined by controlling the reaction parameters.
Synthesis of Chromones through LiOtBu/Air‐Mediated Oxidation and Regioselective Cyclization of o‐Hydroxyphenyl Propargyl Carbinols
Authors: Zhang Shuai , Wan Changfeng , Wang Qiang , Zhang Baiqun , Gao Lingfeng , Zha Zhenggen , Wang Zhiyong 
Published: February 2013

AbstractA cascade oxidative cyclization reaction for the synthesis of chromone derivatives was developed by using LiOtBu as a mediator and air as an oxidant. The reaction was carried out without the assistance of a transition metal under mild conditions to afford the chromones in good yields with high regioselectivities.
Tephrochronology and the late Holocene volcanic and flood history of Eyjafjallajökull, Iceland
Authors: DUGMORE ANDREW J. , NEWTON ANTHONY J. , SMITH KATE T. , MAIRS KERRY‐ANN 
Published: February 2013

ABSTRACTThe hugely disruptive Eyjafjallajökull eruptions of 2010 AD are well known, but the recent history of the volcano is not, which compromises both Icelandic and international hazard assessments and risk planning. This paper identifies and dates the floods caused by two flank eruptions (the c. 920 AD eruption of the Skerin ridge and 6–7th century AD activity around Miðtungugil) and clarifies understanding of c. 6th century AD central vent eruption. These specific contributions to volcanic history are used to illustrate applications of tephrochronology with widespread relevance: how to date eruptions that generate little tephra, better understand the flood hazards presented by glaciated, mountainous volcanoes and the relationship between long‐term patterns of activity in neighbouring volcanoes, in this case Eyjafjallajökull and its close (and much larger) neighbour, the volcano Katla. Copyright © 2013 John Wiley & Sons, Ltd.
A Facile Method for the Preparation of Monodisperse Beads with Uniform Pore Sizes for Cell Culture
Authors: Moon Seung‐Kwan , Oh Myeong‐Jin , Paik Dong‐Hyun , Ryu Tae‐Kyung , Park Kyeongsoon , Kim Sung‐Eun , Park Jong‐Hoon , Kim Jung‐Hyun , Choi Sung‐Wook 
Published: February 2013

AbstractThis paper describes a facile method for the preparation of porous gelatin beads with uniform pore sizes using a simple fluidic device and their application as supporting materials for cell culture. An aqueous gelatin droplet containing many uniform toluene droplets, produced in the fluidic device, is dropped into liquid nitrogen for instant freezing and the small toluene droplets evolve into pores in the gelatin beads after removal of toluene and then freeze‐drying. The porous gelatin beads exhibit a uniform pore size and monodisperse diameter as well as large open pores at the surface. Fluorescence microscopy images of fibroblast‐loaded gelatin beads confirm the attachment and proliferation of the cells throughout the porous gelatin beads.
Multifocal radiculoneuropathy during ipilimumab treatment of melanoma
Authors: Manousakis Georgios , Koch James , Sommerville R. Brian , El‐Dokla Ahmed , Harms Matthew B. , Al‐Lozi Muhammad T. , Schmidt Robert E. , Pestronk Alan 
Published: February 2013

ABSTRACTIntroduction: Ipilimumab, a monoclonal anti–CTLA‐4 antibody, is used to treat melanoma. Neuromuscular side effects, possibly autoimmune, may occur. Methods: In this investigation we undertook a retrospective review of patient records. Results: After 3 doses of ipilimumab, a 31‐year‐old man developed asymmetric, severe weakness involving all limbs, respiration, and cranial nerves, which was progressive over 2 weeks. EMG/NCS showed an axonal polyradiculoneuropathy with multifocal motor conduction blocks. CSF protein was 749 mg/dl. Nerve pathology showed inflammation around the endoneurial microvessels and subperineurial edema and inflammation. Spine MRI showed leptomeningeal and anterior and posterior root enhancement. Strength improved slowly over months after ipilimumab discontinuation and immunomodulating treatment. Conclusions: Ipilimumab toxicity presented as a monophasic, multifocal, asymmetric polyradiculoneuropathy involving roots and peripheral and cranial nerves. Ipilimumab may produce a polyradiculoneuropathy with disruption of the blood–nerve barrier due to a microvasculopathy. Muscle Nerve 48: 440–444, 2013
Simulation of long‐term consolidation behavior of soft sensitive clay using an elasto‐viscoplastic constitutive model
Authors: Karim M.R. , Oka F. , Krabbenhoft K. , Leroueil S. , Kimoto S. 
Published: February 2013

SUMMARYThe phenomenon of excess pore water pressure increase or stagnation and continuing large ground deformation in soft sensitive clay following the completion of construction of embankment is simulated for a case study at Saint Alban, Quebec, Canada. The present model employs an updated Lagrangian finite element framework and is combined with an automatic time increment selection scheme. The simulation based on an elasto‐viscoplastic constitutive model considers soil‐structure degradation effect. It is shown that without consideration for the microstructural degradation effect, it is not possible to reproduce the field responses of soft sensitive clay even during the construction of the embankment. When the soil‐structure degradation effect is considered, the present model can offer reasonably accurate prediction for the consolidation behavior of soft sensitive clay, including the so‐called anomalous pore water pressure generation and continuing large deformation even after the end of construction, which has been posing numerous uncertainties on the long‐term performance of earth structures. Copyright © 2013 John Wiley & Sons, Ltd.
Cooked Bones? Method and Practice for Identifying Bones Treated at Low Temperature
Authors: Solari A. , Olivera D. , Gordillo I. , Bosch P. , Fetter G. , Lara V. H. , Novelo O. 
Published: February 2013

AbstractIs it possible to determine low‐temperature cooking in archaeological bones? The indirect exposure of bones to fire at low temperature (≤ 100 °C), linked to cooking, produces macroscopic modifications on these bones. These modifications have not been clearly or systematically described previously. Instead, physicochemical changes at nanometric level are only now beginning to be understood. In this paper, our principle aim is to explore new methods and techniques that correlate macroscopic features such as smoothness or light transparency with physicochemical characterization results that could aid towards detecting cooked bones in the archaeological record.This study then selected 11 archaeological samples, both human and non‐human. Bones were considered to be thermally treated or not, on the basis of macroscopic criteria. Complementary characterization techniques were used to study morphology (scanning electron microscopy and small angle X‐ray scattering), structure (X‐ray diffraction and transmission electron microscopy), local composition (energy‐dispersive X‐ray spectroscopy) and texture (gas adsorption). Indeed, fractal dimension, particle size, crystalline percentage or specific surface area may well explain some of the macroscopically observed modifications on these samples. The possibility that such apparent modifications may also be due to diagenesis is also considered.From an archaeological point of view, the results are promising. Our characterization of human and non‐human bones demonstrates that physicochemical techniques are complementary and provide good criteria against which to distinguish boiled from un‐boiled archaeological samples. Copyright © 2013 John Wiley & Sons, Ltd.
Deep nuclear resonant tunneling thermal rate constant calculations
Authors: Mandrà Salvatore , Valleau Stéphanie , Ceotto Michele 
Published: February 2013

AbstractA fast and robust time‐independent method to calculate thermal rate constants in the deep resonant tunneling regime for scattering reactions is presented. The method is based on the calculation of the cumulative reaction probability which, once integrated, gives the thermal rate constant. We tested our method with both continuous (single and double Eckart barriers) and discontinuous first derivative potentials (single and double rectangular barriers). Our results show that the presented method is robust enough to deal with extreme resonating conditions such as multiple barrier potentials. Finally, the calculation of the thermal rate constant for double Eckart potentials with several quasi‐bound states and the comparison with the time‐independent log‐derivative method are reported. An implementation of the method using the Mathematica Suite is included in the Supporting Information. © 2013 Wiley Periodicals, Inc.
The investigation of NbO2 and Nb2O5 electronic structure by XPS, UPS and first principles methods
Authors: Weibin Zhang , Weidong Wu , Xueming Wang , Xinlu Cheng , Dawei Yan , Changle Shen , Liping Peng , Yuying Wang , Li Bai 
Published: February 2013

ABSTRACTIn this paper, the electronic structures of NbO2 and Nb2O5 are theoretically and experimentally analyzed. The oxides in the samples are mainly consisted of NbO2 and NbO, whereas the outmost layer of the samples is NbO2. After exposure to air, the outermost layer on all niobium samples is Nb2O5. The photoelectrons from the first 2–4 Å contribute to the spectra, so the valence band structure of NbO2 and Nb2O5 can be confirmed from ultraviolet photoelectron spectroscopy (UPS). By comparing the UPS with density of state results, the electronic structure of NbO2 and Nb2O5 can be distinguished from each other, and then the electronic structure was deconvoluted into several electronic states. The agreement between experimental result and theory is, in the best case, satisfactory. Copyright © 2013 John Wiley & Sons, Ltd.
Transoral robotic surgery for large mixed laryngocoele
Authors: Ciabatti P G , Burali G , D'Ascanio L 
Published: February 2013

AbstractBackground:A laryngocoele is an abnormal dilatation of Morgagni's ventricle in direct communication with the laryngeal lumen. Surgical excision through a cervical approach is traditionally considered the treatment of choice for large (external and mixed) laryngocoeles. This paper describes the first reported case of a large mixed laryngocoele treated with transoral robotic surgery without cervical incisions.Method:A 69-year-old female underwent transoral robotic surgery for the excision of a large mixed left laryngocoele. The surgery was performed using the da Vinci S surgical robotic system (Intuitive Surgical, Sunnyvale, California, USA).Results:No complications were observed and the patient was discharged 2 days post-operation.Conclusion:Transoral robotic surgery enabled accurate dissection with complete removal of the large mixed laryngocoele via a minimally invasive approach. The advantages of transoral robotic surgery over other techniques for laryngocoele excision are discussed.
Endolymphatic sac tumour: case report and literature review
Authors: Virk J S , Randhawa P S , Saeed S R 
Published: February 2013

AbstractObjective:To increase awareness of the presentation, diagnostic difficulties and management of endolymphatic sac tumours.Case reports:A 79-year-old man with a 6-month history of unilateral hearing loss, tinnitus and vertigo, who was suspected to have an endolymphatic sac tumour on imaging, underwent successful transmastoid-translabyrinthine resection. A 53-year-old man with unilateral hearing loss and pulsatile tinnitus underwent subtotal resection of a suspected paraganglioma, which was identified histologically. Due to interval growth, gamma knife radiosurgery was performed followed by subtotal petrosectomy, at which juncture an endolymphatic sac tumour was reported.Methods:A review of the world literature was carried out using Medline, which identified less than 150 reported cases of endolymphatic sac tumour.Conclusion:Endolymphatic sac tumours are rare lesions of the petrous temporal bone. Although benign, they can be locally destructive. At present, there is no consensus regarding the management and long-term follow up of these tumours. Surgical resection is usually favoured, although treatment with radiotherapy and gamma knife surgery has also been reported.
Behavioral characteristics of Chinese adolescents with dyslexia: The use of teachers’ behavior checklist in Hong Kong
Authors: CHING BOBY HO-HONG , HO CONNIE SUK-HAN , CHAN DAVID W. , CHUNG KEVIN K. H. , LO LAP-YAN 
Published: February 2013

ABSTRACTWe developed the Hong Kong Specific Learning Difficulties Behavior Checklist for Junior Secondary School Students (BCL-JS) for teachers to rate the frequency of 52 reading-related behavioral characteristics of Chinese secondary school students. An item factor analysis based on ratings on 947 students yielded seven distinct dimensions. In a separate sample of 90 students, the seven constructs of the BCL-JS significantly correlated with students’ performances on most literacy and reading-related cognitive measures, and differentiated adolescents with or without dyslexia. Discriminant analysis showed that the BCL-JS had a high rate of correct classification (82.2%). These findings support that the BCL-JS is a reliable screening tool for Chinese junior secondary school students at risk for dyslexia.
Evaluating the clinical and economic burden of healthcare-associated infections during hospitalization for surgery in France
Authors: LAMARSALLE L. , HUNT B. , SCHAUF M. , SZWARCENSZTEIN K. , VALENTINE W. J. 
Published: February 2013

SUMMARYOver 4 million patients suffer nosocomial infections annually in the European Union. This study aimed to estimate the healthcare burden associated with healthcare-associated infections (HAIs) following surgery in France, and explore the potential impact of infection control strategies and interventions on the clinical and economic burden of disease. Data on the frequency of HAIs were gathered from the 2010 Programme de Médicalisation des Systèmes d'Information (PMSI), and cost data were taken from the 2009 Echelle Nationale de Coûts à Méthodologie Commune (ENCC). It was estimated that 3% of surgical procedures performed in 2010 in France resulted in infection, resulting in an annual cost of €57 892 715. Patients experiencing a HAI had a significantly increased mortality risk (4·15-fold) and an increased length of hospital stay (threefold). Scenario analysis in which HAI incidence following surgery was reduced by 8% (based on a study of the effectiveness of triclosan-coated sutures), suggested that, annually, 20 205 hospital days and €4 588 519 could be saved. Analyses of 20% and 30% reductions in incidence (based on an estimate of the number of preventable nosocomial infections) suggested that annual savings of €11 548 057 and €17 334 696, respectively, could be made. New infection control interventions which reduce HAI incidence during hospitalization for surgery have the potential to provide valuable cost savings to healthcare providers.
Archaeal and anaerobic methane oxidizer communities in the Sonora Margin cold seeps, Guaymas Basin (Gulf of California)
Authors: Vigneron Adrien , Cruaud Perrine , Pignet Patricia , Caprais Jean-Claude , Cambon-Bonavita Marie-Anne , Godfroy Anne , Toffin Laurent 
Published: February 2013

Abstract
Cold seeps, located along the Sonora Margin transform fault in the Guaymas Basin, were extensively explored during the ‘BIG’ cruise in June 2010. They present a seafloor mosaic pattern consisting of different faunal assemblages and microbial mats. To investigate this mostly unknown cold and hydrocarbon-rich environment, geochemical and microbiological surveys of the sediments underlying two microbial mats and a surrounding macrofaunal habitat were analyzed in detail. The geochemical measurements suggest biogenic methane production and local advective sulfate-rich fluxes in the sediments. The distributions of archaeal communities, particularly those involved in the methane cycle, were investigated at different depths (surface to 18 cm below the sea floor (cmbsf)) using complementary molecular approaches, such as Automated method of Ribosomal Intergenic Spacer Analysis (ARISA), 16S rRNA libraries, fluorescence in situ hybridization and quantitative polymerase chain reaction with new specific primer sets targeting methanogenic and anaerobic methanotrophic lineages. Molecular results indicate that metabolically active archaeal communities were dominated by known clades of anaerobic methane oxidizers (archaeal anaerobic methanotroph (ANME)-1, -2 and -3), including a novel ‘ANME-2c Sonora’ lineage. ANME-2c were found to be dominant, metabolically active and physically associated with syntrophic Bacteria in sulfate-rich shallow sediment layers. In contrast, ANME-1 were more prevalent in the deepest sediment samples and presented a versatile behavior in terms of syntrophic association, depending on the sulfate concentration. ANME-3 were concentrated in small aggregates without bacterial partners in a restricted sediment horizon below the first centimetres. These niche specificities and syntrophic behaviors, depending on biological surface assemblages and environmental availability of electron donors, acceptors and carbon substrates, suggest that ANME could support alternative metabolic pathways than syntrophic anaerobic oxidation of methane.
Short-term observations of marine bacterial and viral communities: patterns, connections and resilience
Authors: Needham David M , Chow Cheryl-Emiliane T , Cram Jacob A , Sachdeva Rohan , Parada Alma , Fuhrman Jed A 
Published: February 2013

Abstract
Observation of short-term temporal variation in bacterial and viral communities is important for understanding patterns of aquatic microbial diversity. We collected surface seawater once daily for 38 consecutive days with seven more samples interspersed over 40 more days at one location ∼2 km from Santa Catalina Island, California. Bacterial communities were analyzed by automated ribosomal intergenic spacer analysis (ARISA) and viral communities were analyzed by terminal restriction fragment length polymorphism (TRFLP) of the conserved T4-like myoviral gene encoding the major capsid protein (g23). Common bacterial and viral taxa were consistently dominant, and relatively few displayed dramatic increases/decreases or ‘boom/bust’ patterns that might be expected from dynamic predator-prey interactions. Association network analysis showed most significant covariations (associations) occurred among bacterial taxa or among viral taxa and there were several modular (highly-interconnected) associations (P⩽0.005). Associations observed between bacteria and viruses (P⩽0.005) occurred with a median time lag of 2 days. Regression of all pairwise Bray-Curtis similarities between samples indicated a rate of bacterial community change that slows from 2.1%–0.18% per day over a week to 2 months; the rate stays around 0.4% per day for viruses. Our interpretation is that, over the scale of days, individual bacterial and viral OTUs can be dynamic and patterned; resulting in statistical associations regarded as potential ecological interactions. However, over the scale of weeks, average bacterial community variation is slower, suggesting that there is strong community-level ecological resilience, that is, a tendency to converge towards a ‘mean’ microbial community set by longer-term controlling factors.
Enrichment of specific protozoan populations during in situ bioremediation of uranium-contaminated groundwater
Authors: Holmes Dawn E , Giloteaux Ludovic , Williams Kenneth H , Wrighton Kelly C , Wilkins Michael J , Thompson Courtney A , Roper Thomas J , Long Philip E , Lovley Derek R 
Published: February 2013

Abstract
The importance of bacteria in the anaerobic bioremediation of groundwater polluted with organic and/or metal contaminants is well recognized and in some instances so well understood that modeling of the in situ metabolic activity of the relevant subsurface microorganisms in response to changes in subsurface geochemistry is feasible. However, a potentially significant factor influencing bacterial growth and activity in the subsurface that has not been adequately addressed is protozoan predation of the microorganisms responsible for bioremediation. In field experiments at a uranium-contaminated aquifer located in Rifle, CO, USA, acetate amendments initially promoted the growth of metal-reducing Geobacter species, followed by the growth of sulfate reducers, as observed previously. Analysis of 18S rRNA gene sequences revealed a broad diversity of sequences closely related to known bacteriovorous protozoa in the groundwater before the addition of acetate. The bloom of Geobacter species was accompanied by a specific enrichment of sequences most closely related to the ameboid flagellate, Breviata anathema, which at their peak accounted for over 80% of the sequences recovered. The abundance of Geobacter species declined following the rapid emergence of B. anathema. The subsequent growth of sulfate-reducing Peptococcaceae was accompanied by another specific enrichment of protozoa, but with sequences most similar to diplomonadid flagellates from the family Hexamitidae, which accounted for up to 100% of the sequences recovered during this phase of the bioremediation. These results suggest a prey–predator response with specific protozoa responding to increased availability of preferred prey bacteria. Thus, quantifying the influence of protozoan predation on the growth, activity and composition of the subsurface bacterial community is essential for predictive modeling of in situ uranium bioremediation strategies.