bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure
Authors: Lee Rebecca , Xu Bin , Rame J. Eduardo , Felkin Leanne E. , Barton Paul , Dries Daniel L. 
Published: December 2014

Background

The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments. Natriuretic peptide pro‐peptide processing is accomplished by corin, a transmembrane serine protease expressed by cardiomyocytes.
Brain natriuretic peptide (BNP)
processing is inadequate in advanced heart failure and is independently associated with adverse outcomes; however, the molecular mechanisms causing impaired
BNP
processing are not understood. We hypothesized that the development of endoplasmic reticulum stress in cardiomyocytes in advanced heart failure triggers inositol‐requiring protein 1 (
IRE
1)‐dependent corin
mRNA
decay, which would favor a molecular substrate favoring impaired natriuretic peptide pro‐peptide processing.

Methods and Results

Two independent samples of hearts obtained from patients with advanced heart failure at transplant demonstrated that corin
RNA
was reduced as
Atrial natriuretic peptide (ANP)
/
BNP RNA
increased. Increases in spliced X‐box protein 1, a marker for
IRE
1‐endoribonuclease activity, were associated with decreased corin
RNA
. Moreover, ≈50% of the hearts demonstrated significant reductions in corin
RNA
and protein as compared to the nonfailing control sample. In vitro experiments demonstrated that induction of endoplasmic reticulum stress in cultured cardiomyocytes with thapsigargin activated
IRE
1's endoribonuclease activity and time‐dependent reductions in corin
mRNA
. In
HL
‐1 cells, overexpression of
IRE
1 activated
IRE
1 endoribonuclease activity and caused corin
mRNA
decay, whereas
IRE
1‐
RNA
interference with sh
RNA
attenuated corin
mRNA
decay after induction of endoplasmic reticulum stress with thapsigargin. Pre‐treatment of cells with Actinomycin D to inhibit transcription did not alter the magnitude or time course of thapsigargin‐induced corin
mRNA
decline, supporting the hypothesis that this was the result of
IRE
1‐mediated corin
mRNA
degradation.

Conclusions

These data support the hypothesis that endoplasmic reticulum stress‐mediated,
IRE
1‐dependent targeted corin
mRNA
decay is a mechanism leading to corin
mRNA
resulting in corresponding corin protein deficiency may contribute to the pathophysiology of impaired natriuretic peptide pro‐hormone processing in humans processing in humans with advanced systolic heart failure.
Modeling in Earth system science up to and beyond IPCC AR5
Authors: Hajima Tomohiro , Kawamiya Michio , Watanabe Michio , Kato Etsushi , Tachiiri Kaoru , Sugiyama Masahiro , Watanabe Shingo , Okajima Hideki , Ito Akinori 
Published: December 2014

Abstract
Changes in the natural environment that are the result of human activities are becoming evident. Since these changes are interrelated and can not be investigated without interdisciplinary collaboration between scientific fields, Earth system science (ESS) is required to provide a framework for recognizing anew the Earth system as one composed of its interacting subsystems. The concept of ESS has been partially realized by Earth system models (ESMs). In this paper, we focus on modeling in ESS, review related findings mainly from the latest assessment report of the Intergovernmental Panel on Climate Change, and introduce tasks under discussion for the next phases of the following areas of science: the global nitrogen cycle, ocean acidification, land-use and land-cover change, ESMs of intermediate complexity, climate geoengineering, ocean CO2 uptake, and deposition of bioavailable iron in marine ecosystems. Since responding to global change is a pressing mission in Earth science, modeling will continue to contribute to the cooperative growth of diversifying disciplines and expanding ESS, because modeling connects traditional disciplines through explicit interaction between them.
Survey of the Hymenoptera Fauna in a "Caatinga" Area in the State of Rio Grande do Norte, Northeastern Brazil
Authors: Fernandes Daniell Rodrigo Rodrigues , Guimarães Jorge Anderson , Araujo Elton Lucio , Lara Rogéria Inês Rosa , Perioto Nelson Wanderley 
Published: December 2014

The aim of this study was to carry out a survey of the fauna of the Hymenoptera families in an area of Caatinga in Mossoró, state of Rio Grande do Norte, Brazil. The samplings were carried out with Malaise traps, active between 6th of February and 6th of March, 2007 and between 13th March and 14th April, 2008. A total of 5,057 Hymenoptera, belonging to 12 superfamilies and 36 families, were collected. The most abundant superfamilies were: Chalcidoidea (1,206 specimens/23.85% of the total), Vespoidea (886/17.52%), Ichneumonoidea (837/16.55%) and Platygastroidea (801/15.84%) and the most abundant families were: Platygastridae (801/15.84%), Braconidae (616/12.18%), Pteromalidae (583/11.53%), Figitidae (454/8.98%), Pompilidae (444/8.78%) and Formicidae (268/5.30%). The data obtained allow us to affirm that the Caatinga encompasses substantial family richness of Hymenoptera and that renewed effort is necessary to sample its fauna in a more extensive way.
Levantamento da Fauna de Hymenoptera em uma Área de Caatinga do Estado do Rio Grande do Norte, Nordeste do Brasil

Resumo. O objetivo deste estudo foi realizar levantamento das famílias de himenópteros presentes em área de Caatinga em Mossoró, Estado do Rio Grande do Norte, Brasil. As amostragens foram realizadas com armadilhas Malaise, entre 6 de fevereiro e 6 de março de 2007 e 13 de março e 14 de abril de 2008. Foram coletados 5.057 himenópteros pertencentes a 12 superfamílias e 36 famílias. As superfamílias mais abundantes foram: Chalcidoidea (1.206 exemplares/23,85% do total), Vespoidea (886/17,52%), Ichneumonoidea (837/16,55%) e Platygastroidea (801/15,84%) e as famílias mais abundantes foram: Platygastridae (801/15,84%), Braconidae (616/12,18%), Pteromalidae (583/11,53%), Figitidae (454/8,98%), Pompilidae (444/8,78%) e Formicidae (268/5,30%). Os dados obtidos demonstram grande riqueza de famílias de himenópteros na Caatinga e que estudos adicionais são necessários para estabelecer a riqueza desta fauna de forma mais extensiva.
Modular form as a curatorial practice
Authors: Marczewska Kaja 
Published: December 2014

Abstract
This article discusses a curatorial approach to authorship as a model for thinking about what I describe as an iterative modular poem, a poetic text composed of appropriated segments. As a response to contemporary proliferation of literary and artistic works created by iterative means, i.e. through acts of appropriation, remixing and remediation, the article is an attempt at putting forward ‘the curatorial’ as an emerging paradigm of writing for the twenty-first century. The article approaches established paradigms of authorship, creativity and originality as inadequate with respect to contemporary experimental poetic practices to suggest a shift from creating to collecting and curating as a possible alternative model for thinking about instances of iterative creative writing. The argument focuses on Robert Fitterman’s Holocaust Museum (2011) as an example of an iterative modular poem and a text emblematic of such curatorial approach to authorship.
Excerpt from The Fundamental Questions
Authors: Weichbrodt Gregor , Bennett Vicki 
Published: December 2014

Abstract
Who am I? Where do I come from? What is my purpose in Life and what happens when I die? For centuries people have tried to come up with answers regarding the fundamental questions of life. Then the Internet was invented and these questions have finally been answered – by users. The book The Fundamental Questions captures these questions in an inspiring record of epic proportions where every individual verse becomes a mantra of a mind-expanding collective thought. It reminds us, that one single answer is never the answer. Thousands of user profiles from the web were parsed, matched according to four questions and sorted in an alphabetical order.
Richtlinien zur barrierefreien Gestaltung virtueller Klassenzimmer für Blinde / Guidelines for the Accessible Design of Virtual Classrooms for the Blind
Authors: Köhlmann Wiebke 
Published: December 2014

Zusammenfassung
E-Learning kann den Zugang zu Lernmaterialien für Lernende mit Behinderung erleichtern. Jedoch treten insbesondere für blinde Nutzer Barrieren bei der Verwendung visuell dominierter synchroner Lernarrangements auf. Die vorhandenen barrierefreiheitsfördernden Funktionen erleichtern die Teilnahme blinder Nutzer, können jedoch eine gleichberechtigte Verwendung nicht garantieren. Dieser Artikel fasst eine Produktanalyse virtueller Klassenzimmer zusammen und stellt einen funktionalen Katalog mit Richtlinien an für blinde Nutzer zugängliche virtuelle Klassenzimmer vor.
A note on the functional distribution of ille in Late Latin
Authors: Pieroni Silvia 
Published: December 2014

Abstract
This paper deals with the distribution of adnominal ille in Late Latin. While the literature on the topic is substantial, the aim of the paper is not to seek attestations of ille which foreshadow its article or article-like function, but simply to look for some functional properties that allow for its future development as a marker of definiteness. Moreover, this paper aims at considering the distribution of ille in the context of the propositional structure taken as a whole. The Peregrinatio Aetheriae is first analysed, as a privileged text for looking at a redundant use of adnominal ille. In this text, the frequency of occurrences of adnominal ille appears to be linked to the frequency of presentative structures: in particular, ille is often found within post-verbal noun phrases which, even while fulfilling the subject function, combine a predicative and/or rhematic function with the argumental one, precisely as in existential and presentative structures. The hypothesis may thus be suggested that ille occurs as a marker of nominative nominals which occur in “atypical” combinations of syntactic and pragmatic functions and in correlation with a marked linear order. In a second step, this analysis is checked against a further corpus, drawn from St. Augustine’s Confessiones where, again, ille is found either as a marker of nominals which, in addition to functioning as arguments, have a predicative and rhematic value, or as a marker of nominals which occur in propositional structures where other nominal (or adjectival) elements are involved as predicates as well.
Probabilistic representations of matrix variate skew normal models
Authors: Ning Wei 
Published: December 2014

Abstract
Azzalini [Scand. J. Stat. 12 (1985), 171–178] first introduced the skew normal
distribution family with a shape parameter λ, and then
extended this family by adding an additional shape
parameters ξ. Basic properties of these two families were
studied. Henze [Scand. J. Stat. 13
(1986), 271–275] gave the probabilistic representations for
these two families by interpreting it as the linear combination of a
normal random variable with another normal random variable truncated
at the origin and several properties were illustrated. Chen and
Gupta [Statistics 39 (2005), no. 3, 247–253] extended the skew normal distribution family to the
matrix variate and proposed the moment generating function and the
quadratic form of the matrix variate skew normal models. Motivated
by these results, we first study the probabilistic representation
for the matrix variate skew normal models and several properties.
Then we define the extended skew normal model of the matrix variate,
and give the probabilistic representation for this family and its
extension.
To Be or not to Be: Band-Like Transport in Quantum Dot Solids
Authors: Scheele Marcus 
Published: December 2014

Abstract
Recent experimental data on charge carrier transport in quantum dot
solids is analyzed in light of the question whether band-like
transport is the most plausible mechanism to account for the observed
behavior. Upon reviewing some physical fundamentals of
temperature-activated hopping, small polaron hopping and band-like
transport, it is established that a combined approach of different
experimental methods is required to achieve a satisfactory degree of
unambiguousness to address this question. In doing so, at least one
example is identified for which a high degree of supporting evidence
exists that transport is in fact diffusive. It is highlighted that
temperature-dependent Hall Effect measurements play an important role
in this respect.
Calidad de vida y medio ambiente: residuos sólidos y bienestar en tres escuelas de la cuenca alta del río la Sabana, Acapulco, Guerrero, México
Authors: Cañedo-Villareal Roberto , Barragán Mendoza María del Carmen , Olivier Salomé Branly , Júarez-Romero Octaviano 
Published: December 2014

Este artículo presenta resultados de investigación respecto a la clasificación de residuos sólidos urbanos (RSU) generados por tres escuelas (primaria, secundaria y bachillerato) de la cuenca alta del río La Sabana, en Acapulco, México. Además identifica el nivel de vida de las familias de los estudiantes de dichas escuelas y la calidad de vida (INCAVI) de un grupo representativo del “Kilómetro 42”. La clasificación in situ de los RSU se hizo bajo las normas oficiales mexicanas; el nivel de vida se determinó de acuerdo con la regla AMAI 10X6 y el INCAVI, con la técnica de la comisión Stiglitz del gobierno francés. La primaria reportó la generación de 620 kg por ciclo escolar-1 de RSU, 5,7 kg per cápita, principalmente papel (25%); la secundaria, 1295 kg, 10,5 kg per cápita, y residuos de jardinería (13%); mientras que el bachillerato reportó 1196 kg, 11,5 kg per cápita, y plástico rígido (26%). Respecto al nivel de vida, clasificado en seis estratos, el 65% de familias de la escuela primaria está entre el primero y el segundo, 30% entre tercero y cuarto, y 5% entre quinto y sexto; de la secundaria, 21%, 68,4% y 10,6%; del bachillerato, 64,7%, 35,3% y 0%; consideradas las tres escuelas: 50%, 44,6% y 5,4%, respectivamente. Respecto a la percepción personal de calidad de vida, el 50% de las personas la considera buena, 31,3% mala y 18,8% muy mala; con el INCAVI resulta: 31,3% buena, 62,5% mala y 6,3% muy mala. Esto es una percepción positiva ante condiciones de vida escasas.
Magnetization and magnetocaloric effect in La0.7Pb0.3MnO3 ceramics and 0.85(La0.7Pb0.3MnO3)–0.15(PbTiO3) composite
Authors: Mikhaleva Ekateina , Eremin Evgeniy , Flerov Igor , Kartashev Andrey , Sablina Klara , Mikhashenok Nataly 
Published: December 2014

Abstract
Formulation and Quality Evaluation of Extruded Product From Composite Blend of Maize, Sorghum and Ricebean
Authors: Lamichhane Bandana , Ojha Pravin , Paudyal Bhupendra 
Published: December 2014

This research work was based on formulation of cereal based extruded product utilizing the underutilized grains of Nepal i.e. sorghum (white variety) and ricebean (yellow variety). The formulation having 76% maize, 15% sorghum and 9% ricebean was found best through sensory analysis. While further variation in grit particle size ranging from 550 μm to 1190 μm, the product formulated with average particle size of 1090 μm was found to have best. The optimum grit size was selected by sensory analysis, chemical analysis and physico-chemical analysis. The expansion value for product of 1090 μm grit size was maximum 3.88±0.36, and minimum value 3.02±0.14 for smaller particle size 550 μm. The density was minimum, 80.46±12.72 kg/m3 for product of 1090 μm grit size and maximum, 175.33±11.89 kg/m3 for product of 550 μm grit size. The soluble fiber, β-glucan, WAI (water absorption index) and WSI (water soluble index) were found to be 6.52±0.61 % (db), 9.77±0.52 and 21.48±0.82 respectively for final product of grit size 1090 μm. DOI: http://dx.doi.org/10.3126/jfstn.v8i0.11748 J. Food Sci. Technol. Nepal, Vol. 8 (40-45), 2013
Development and quality assessment of functional probiotic yoghurt drink from sweet cream buttermilk
Authors: Chapagain Kshiteej , Karki Tika Bahadur , Ojha Pravin 
Published: December 2014

A new functional yoghurt drink consisting of banana and honey was developed from Sweet Cream Buttermilk (SCBM)and its physicochemical, microbiological and sensory characteristics were assessed with respect to plain and skim milk yoghurt drinks. Storage stability of drinks prepared by using standard probiotic culture of lactobacillus acidophilus (La5) was determined in terms of acidity, strain viability and consumer acceptability of final products. In corporation of banana and honey decreased post acidification and increased the carbohydrate (13.15-13.37%), proteins (2.23-2.25%) and ash content (0.53%). It was observed that the total solid content was increased from 5.72±0.17 % in plain yoghurt drink (PYD) to 16.39±0.07% in skim milk based drink (SYD) and 16.38±0.04% in buttermilk based drink (BYD). Greater count of probiotic cells was observed in Buttermilk based yoghurt drink (5.9*108 CFU/ml) than in Skim milk based yoghurt drink (1.4*108 CFU/ml) at the end of 30 days of refrigerated storage. Fifty percent of the consumer preferred refrigerated Buttermilk based yoghurt drink for 27 days. DOI: http://dx.doi.org/10.3126/jfstn.v8i0.11750 J. Food Sci. Technol. Nepal, Vol. 8 (52-59), 2013
Sulfonamides and Penicillin Residue in Market Milk
Authors: Thapaliya Manish , Karki Tika B. , Sedai Damodar 
Published: December 2014

The present study was conducted at laboratory of Veterinary Standards and Drug Administration Office, Tripureshwor, Kathmandu in the month of October to December 2007 with aim of determining the prevalence and level of sulfonamide and penicillin residue semi-quantitatively in market milk samples from Kathmandu, Lalitpur, Bhaktapur and Kavrepalanchowk districts. All the samples were processed using standard procedure given in the protocol of the rapid residue test kit provided by the Division of Food, Department of Medical Sciences, Ministry of Public Health, Thailand. The prevalence of antibiotic residue was found to be 17.3% (n=26) of the total of 150 samples collected. Out of the total samples 12% (n=18) were found to contain penicillin residue and 5.3% (n=8) were found to contain sulfonamide residue. Sulfonamide residue was detected in the range of 0-1 ppb in 6 samples and 2-4 ppb in 2 samples. Similarly, penicillin residue was found in the range of 0-1 ppb in 14 of the samples and 2-4 pbb in 4 samples. The residues level detected were below their MRLs as set by the Codex Alimentarius Commission. The occurrence of the antibiotic residue in the tested milk samples was compared whether it differs from district to district. Statistically, there was no significant difference on the occurrence of the antibiotic residue in the tested milk from district to district. DOI: http://dx.doi.org/10.3126/jfstn.v8i0.11751 J. Food Sci. Technol. Nepal, Vol. 8 (60-64), 2013
Obstetric Hysterectomy and Maternal Survival
Authors: Baral J , Gurung G , Rana A , Manandhar B , Manandhar R , Sharma J 
Published: December 2014

Aims: This study was done to analyze the cases of obstetric hysterectomy and maternal complications and survival after that. Methods: A retrospective study was carried out from the review of records of the near miss, maternal mortality, cesarean audit and operation theater record of the Department of Obstetrics and Gynaecology, Tribhuvan University Teaching Hospital (TUTH), Kathmandu from 2057-2071 BS. Results: Fourteen maternal survival resulted following total of 19 obstetric hysterectomy, subtotal hysterectomy being the procedure of choice in 11 cases, emergency peripartum hysterectomy (EPH) being performed in abundance (18/19) in comparison to an elective peripartum hysterectomy, which was undertaken in a single case of placenta percreta, and inclusive of latter were four cases of morbid placental adhesion, a placenta increta and two placenta accreta. Eight out of 19 cases had vaginal delivery and rest had cesarean section. Among seven cases of cesarean hysterectomy 3 were done for placenta previa with accreta one case each done for abruptio placentae and placenta accreta and two cases were done for extra placental causes. Among four cases of emergency peripartum hysterectomy (EPH), which were relaparotomy followed by hysterectomy, three cases were done for complication of cesarean section and one done for uterine atonicity. Four cases of spontaneous vaginal deliveries needed peripartum hysterectomy two of them were complicated by morbid placental adhesion placenta increta (1), placental percreta (1), two cases were vaginal birth after cesarean (VBAC). Seven cases of uterine rupture had undergone peripartum hysterectomy. Conclusions: Obstetric hysterectomy is a lifesaving surgical procedure for maternal survival whenever necessary and mandates a quick decision making process, however in consideration of younger age and low parity or nulliparity, the best obstetric governance and services must foresee not to let mothers meet such situation necessitating organ removal and to enjoy potential reproductive life cycle.DOI: http://dx.doi.org/10.3126/njog.v9i2.11759
Vault Haematoma after Vaginal Hysterectomy
Authors: Batish A , Sathiyathasan S , Jeyanthan K 
Published: December 2014

Electronic searches of literature published between 1980 and 2014 were undertaken using MEDLINE, Embase, CINHAL, and the Cochrane Database of Systemic reviews. Search items included: haematoma, hysterectomy, morbidity, ultrasound. The incidence of vault hematomas varied from 25- 59 % in various studies. Small hematomas can be managed conservatively and large and infected hematomas need incision and drainage. However various studies found no correlation between the presence of a collection and indices of postoperative morbidity. Also routine scan was not indicated. The incidence of vault hematomas is due to inadequate haemostasis and refining the surgical technique significantly reduces the risk of vault hematomas. DOI: http://dx.doi.org/10.3126/njog.v9i2.11768
Fetal Transcerebellar Diameter/ Abdominal Circumference Ratio as a Gestational Age Independent Parameter for Fetal Growth
Authors: Jha A , Joshi B , Pradhan S 
Published: December 2014

Aims: The purpose of this study was to evaluate accuracy of trans-cerebellar diameter / abdominal circumference (TCD/AC) ratio to assess fetal growth. The ratio of TCD with head circumference (HC) and biparietal diameter (BPD) was also determined. Methods: This was a prospective cross-sectional study involving 442 women with uncomplicated singleton gestation between 15-40 weeks. Protocol included obtaining the BPD, HC, TCD and AC in conventional planes and obtaining ratio of TCD with other biometric parameters.Results: We were able to visualize the cerebellum in about 93% of scans. The TCD/ AC ratio remained nearly constant throughout gestational age and was 0.138. The mean TCD/HC ratio was 0.124 and mean TCD/BPD ratio was 0.476.Conclusions: TCD/HC and TCD/BPD ratio showed a small increase towards the completion of gestation while TCD/AC ratio remained nearly constant throughout gestational age. TCD/AC ratio is reliable as a gestational age independent parameter of fetal growth.DOI: http://dx.doi.org/10.3126/njog.v9i2.11770