bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemically Modified Gold Superatoms and Superatomic Molecules
Authors: Nishigaki Jun‐ichi , Koyasu Kiichirou , Tsukuda Tatsuya 
Published: July 2014

AbstractClusters of gold atoms can be viewed as superatoms, in which valence electrons confined in the particles occupy atomic‐like, discrete electronic levels. Chemical modification of the gold superatoms and their aggregated molecules (superatomic molecules) with organic ligands is a promising approach for their application as the building units of new functional materials. This account surveys the present status of the rapidly growing field of gold superatoms and superatomic molecules protected by thiolates and phosphines. The major aim of this article is to provide a simple picture for the structure, stability and bonding scheme of chemically modified superatoms and superatomic molecules for the development of a new class of hierarchical materials.
Chemistry without Bo(a)rders
Authors: Tanzer Eva‐Maria 
Published: July 2014

Note from the Editor:Science, collegiality, travel without borders. Big smiles and warmth. Eternally youthful vigor. When I think of Tetsuo Nozoe, these are the images that immediately come to mind. When I think of the Nozoe Autograph Books, I also think of time. For 40 years, Nozoe carried with him his autograph books and collected his treasures which The Chemical Record is now publishing. Vladimir Prelog signed first when he was 47 and signed last when he was almost 80. Derek Barton signed first when he was 35 and signed last when he was almost 70. Time! I was fascinated by Eva Wille's recommendation that we publish an essay by Eva‐Maria Tanzer, a young organic chemist with already a lifetime's experience in exploring chemical research in laboratories around the world. Tanzer brings to us a charming, even innocent perspective that embraces so much of Tetsuo Nozoe's ideals. We are privileged to include Tanzer's vision and her experiences in the collection of essays that accompany the Nozoe Autograph Books. Our contributors range in age and experiences, from the youthful Tanzer to the more mature (including myself!) as do the signatories in the autograph books. Tetsuo Nozoe would have beamed!—Jeffrey I. SeemanGuest EditorUniversity of RichmondRichmond, Virginia 23173, USAE‐mail: jseeman@richmond.edu
Accumulation of di(2‐ethylhexyl) phthalate causes endocrine‐disruptive effects in marine medaka (Oryzias melastigma) embryos
Authors: Ye Ting , Kang Mei , Huang Qiansheng , Fang Chao , Chen Yajie , Liu Liangpo , Dong Sijun 
Published: July 2014

ABSTRACTDi (2‐ethylhexyl) phthalate (DEHP) is extensively distributed in marine environments. However, limited research on the toxicological and molecular effects of DEHP on marine organisms has been conducted. Our study investigated the accumulation, elimination, and endocrine‐disruptive effects of DEHP on embryonic marine medaka (Oryzias melastigma). The medaka embryos were continuously exposed to DEHP (0.01, 0.1, and 1 mg/L) or 17β‐estradiol (E2, 0.01 mg/L) until hatching, and the newly hatched larvae were then transferred to clean sea water for 12 days of depuration. DEHP and E2 appeared to have no significant effects on the mortality and hatching rates of medaka embryos, but E2 exposure significantly delayed the hatching. Significantly higher DEHP embryonic burdens were detected in the group treated with higher DEHP (0.1 and 1 mg/L) at 10 dpf (days post fertilization). The recovered larvae showed an elimination tendency of DEHP during the recovery period. DEHP had no significant effects on the transcriptional responses of endocrine‐disrupting biomarker genes in the 3‐dpf embryos. Treatment with 0.1 and 1 mg/L DEHP elicited a significant induction of transcriptional responses of ER, PPAR, and the CYP19 genes in a concentration‐dependent manner at 10 dpf, indicating endocrine disruption may be due to bioaccumulation of DEHP. With the elimination of DEHP during the depuration period, all of the effects on these genes showed no significant effects. However, 0.1 mg/L E2 significantly affected the expression of ER, PPAR, and the CYP19 genes in the exposed embryos at both 3 and 10 dpf and recovered larvae. Therefore, these results demonstrate that accumulation of DEHP caused endocrine disruption in medaka embryos and that recovery in clean sea water may weaken the endocrine‐disrupting effects. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 116–127, 2016.
Does it Matter How We Pose the Question “How is Your Sense of Smell?”
Authors: Wehling Eike , Lundervold Astri J. , Nordin Steven 
Published: July 2014

Abstract
There is a rather large, and unfortunate, discrepancy in the outcome between self-reported and standardized assessment of olfactory function. Questions for self-evaluation are commonly used that provide no information of with what to compare (comparison target) one’s olfactory function. We therefore investigated whether responses differed between an unspecific question and two questions providing comparison targets. Ninety-six healthy community-dwelling individuals (62.5 % women) aged 49–80 years evaluated their odor identification ability, followed by standardized assessment of odor identification ability. Results revealed that response patterns varied significantly depending on comparison target. While 81 % reported normal function when no further comparison target was presented, 69 % reported normal function when referring to age-related olfactory changes in identification ability. In turn, sensitivity of the accuracy of self-reported reduced odor identification ability (with standardized assessment as reference) increased from 11 to 37 %, whereas specificity decreased from 86 to 71 % when providing a comparison target. Accuracy of self-reported olfactory function can be increased by including a comparison target. However, standardized assessment is to be preferred over self-reported assessment, irrespective of how the question is formulated.
Isospectral periodic Torii in dimension 2
Authors: Waters Alden 
Published: July 2014

We consider two dimensional real-valued analytic potentials for the Schrödinger equation which are periodic over a lattice

\mathbb{L}

. Under certain assumptions on the form of the potential and the lattice

\mathbb{L}

, we can show there is a large class of analytic potentials which are Floquet rigid and dense in the set of

C^{\infty }(\mathbb{R}^{2}/ \mathbb{L})

potentials. The result extends the work of Eskin et al., in “On isospectral periodic potentials in

\mathbb{R}^{n}

, II.”

Résumé

Nous considérons les potentiels analytiques à valeurs réelles en dimension deux pour l'equation de Schrödinger qui sont périodiques sur un réseau

\mathbb{L}

. Sous certaines hypothèses sur la forme du potentiel et du réseau

\mathbb{L}

, nous montrons qu' il y a une grande classe de potentiels analytiques Floquet rigides et denses dans l'ensemble de

C^{\infty }(\mathbb{R}^{2}/ \mathbb{L})

potentiels. Ce résultat prolonge le travail de Eskin et al., dans “Les potentiels périodiques isospectraux dans

\mathbb{R}^{n}

, II.”
Impact of nutritional recovery with linear growth on the concentrations of adipokines in undernourished children living in Brazilian slums
Authors: Martins Vinicius J. B. , Neves Andrea P. O. , Franco Maria do C. P. , Clemente Ana P. G. , Sawaya Ana L. 
Published: July 2014

Undernutrition in early life has been reported to be closely associated with the development of non-communicable diseases in adulthood. Adequate treatment is important for reversing these effects. In the present study, we investigated the effects of undernutrition and anthropometric recovery on the weights and heights of children in relation to the concentrations of leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). A total of 119 children (aged 6–16 years) from the slums of São Paulo were selected according to their nutritional status and divided into three groups as follows: control (healthy without intervention, n 38) with a height-for-age Z score (HAZ) and a BMI-for-age Z score (BAZ) > − 1·6; undernourished (HAZ and/or BAZ < − 1·6, n 54); recovered from undernutrition (after treatment in a rehabilitation centre; HAZ and BAZ > − 1·6, n 27). Blood samples were collected to determine insulin, glucose, leptin, adiponectin and PAI-1 concentrations. Leptin concentrations in the undernourished group were lower than those in the control and recovered groups (mean 0·92 (95 % CI 0·67, 1·25), 2·03 (95 % CI 1·46, 2·82) and 1·66 (95 % CI 1·15, 2·44) ng/ml, P= 0·003), which had similar leptin concentrations. There were no differences in adiponectin and PAI-1 concentrations among the groups. A positive correlation between waist circumference and leptin concentrations was observed in all the girls and boys of the control group (control: r 0·729, P< 0·01; undernourished: r 0·490, P< 0·05; and recovered: r 0·829, P< 0·01; r 0·673, P< 0·05). Stronger correlations between leptin and insulin concentrations were observed in the recovered group. The results of the present study indicate that normal leptin concentrations are found when normal height and weight are achieved.
Characterization of a human–pathogenicAcanthamoeba griffiniisolated from a contact lens-wearing keratitis patient in Spain
Authors: HEREDERO-BERMEJO I. , CRIADO-FORNELIO A. , DE FUENTES I. , SOLIVERI J. , COPA-PATIÑO J. L. , PÉREZ-SERRANO J. 
Published: July 2014

SUMMARYAmoebae were isolated from contact lenses of a symptomatic lens wearer in Spain. Protozoa were characterized by studying their morphology, biology, protease activity and the 18S rRNA gene sequence. Morphology of the organism was observed by light microscopy, scanning electron microscopy and transmission electron microscopy. Its structure corresponded to an amphizoic amoeba. The protozoa grew well at 37 °C and poorly at lower temperatures. In addition, it was capable of lysing mammalian cellsin vitro. A major 56 kDa proteolytic enzyme was observed in amoeba crude extracts by gelatin–sodium dodecyl sulphate–polyacrylamide gel electrophoresis. Most proteolytic enzymes in protozoa extracts showed significant activity over a wide range of pH (3–9) and temperature (8–45 °C) values. The assays on inhibition of protease activity indicated strongly that enzymes detected in amoeba extracts corresponded to serine proteases and, to a lesser extent, cysteine proteases. The use of proteinase inhibitors on a tissue culture model proved that the proteinase activity is critical for developing focal lesions in HeLa cell monolayers. Finally, partial sequencing of the 18S ribosomal RNA gene and phylogenetic analyses indicated that the isolate is closely related toAcanthamoeba griffiniH37 from the UK (T3 genotype).
Trajectory generator design based on the user's intentions for a CMC lower-limbs rehabilitation device
Authors: Seddiki L. , Guelton K. , Zaytoon J. , Akdag H. 
Published: July 2014

SUMMARYThis paper deals with the design of the control structure of a lower-limbs rehabilitation device in closed muscular chain called Sys-Reeduc. This control structure aims at providing a safe behavior to the user when performing rehabilitation exercises. It is based on two levels. The first level is concerned with the robust trajectory tracking of robotic device and has been the subject of previous studies. Nevertheless, it does not allow, by itself, the user to voluntarily drive the device. Therefore, a trajectory generator constituting the second level is presented in this paper to complete the whole control structure. This high-level control layer is described by a set of dedicated discrete state machines that provide the appropriate sequencing of elementary rehabilitation movements. These elementary movements are dynamically characterized so that clinician may choose the required trajectory parameters to adapt rehabilitation protocols and training to each individual. To realize a complete rehabilitation exercise, the sequence of elementary movements is triggered by thresholds relative to the measurement of the efforts applied by the user on the device. This allows the user to play an active role in its rehabilitation exercises and safely drive the machine at his/her own initiative. The design of the main exercises (isokinetic, isometric, and isotonic) used in the context of lower limbs rehabilitation is described, and simulation results illustrate the effectiveness of the proposed trajectory generator-based control approach.
RITUXIMAB AND TOCILIZUMAB FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
Authors: González-Vacarezza Nicolás , Alemán Alicia , González Graciela , Pérez Ana 
Published: July 2014

Objectives: The aim of this study was to evaluate the efficacy and safety of rituximab and tocilizumab compared with adalimumab, etanercept, and infliximab, in patients with rheumatoid arthritis not responding to first-line treatment, and to compare the efficacy and safety of rituximab versus tocilizumab in patients not responding to anti-tumor necrosis factor α (anti-TNF) therapy.Methods: A literature search of randomized controlled trials, controlled clinical trials, and systematic reviews was performed to evaluate efficacy and safety of rituximab and tocilizumab.Results: Twenty-four RCTs were included in this systematic review with 6,357 participants; 3,450 treated with biological DMARD and 2,907 with standard care. In patients not responding to first-line treatment, rituximab shows lower response rate in at least 50 percent improvement in the American College of Rheumatology criteria (ACR50) and ACR70 compared with etanercept, at 6 months of follow-up. Tocilizumab shows higher ACR70 response rate compared with infliximab, at the same follow-up time. Other results showed no significant differences. Indirect comparisons between rituximab and tocilizumab in patients not responding for at least one anti-TNF, shows higher ACR20 response rate for tocilizumab at 6 months of follow-up. Regarding safety, adalimumab and etanercept were associated with significant fewer withdrawals due to adverse events compared with infliximab.Conclusions: Considering efficacy, safety, and the availability of 3 anti-TNFs in the National Medicines Formulary (adalimumab, etanercept, and infliximab), it seems appropriate to remove infliximab from the coverage, and introduce tocilizumab for patients not responding for at least one anti-TNF.
The Influence of Qing Dynasty Editorial Work on the Modern Interpretation of Mathematical Sources: The Case of Li Rui's Edition of Li Ye's Mathematical Treatises
Authors: Pollet Charlotte-V. 
Published: July 2014

ArgumentRecent studies in Sinology have shown that Qing dynasty editors acted as philologists. This paper argues that the identification of their philological methods and editorial choices suggests that their choices were not totally neutral and may have significantly shaped the way modern historians interpreted specific works edited by mathematicians of that dynasty. A case study of the re-edition in 1798 of a Song dynasty treatise, theYigu yanduan(1259), by a Qing dynasty mathematician will illustrate this point. At the end of the eighteenth century, Li Rui (1773–1817) was asked to prepare an edition of the mathematical works written by Li Ye (1192–1279) for a private collection. Li Rui was a talented mathematician, but he was also a meticulous editor and trained philologist. He adopted his editorial model from the preparation of the imperial encyclopaedia, theSiku quanshu, but Li Rui also made some corrections to the text in an effort to restore an older version of Li Ye's treatises that had been lost. Convinced of the Chinese origin of algebra, Li Rui used philological techniques to recover the lost materials and to restore the roots of “Chinese mathematics.” TheYigu yanduancontains two algebraic procedures to set up quadratic equations, one from the procedure ofCelestial Source(tian yuan shu) and the other from theSection of Pieces[of Areas] (tiao duan). Curiously, the second procedure has not yet attracted the attention of scholars so far, although Li Rui's edition is the one typically used by twentieth-century historians of mathematics. Today, theCelestial Sourcecharacterizes “Chinese algebra.” However, the specific concerns of Li Rui about the procedure ofCelestial Source, combined with his editorial methods, contributed to this perspective.
Siting the New Economic Science: The Cowles Commission's Activity Analysis Conference of June 1949
Authors: Düppe Till , Weintraub E. Roy 
Published: July 2014

ArgumentIn the decades following World War II, the Cowles Commission for Research in Economics came to represent new technical standards that informed most advances in economic theory. The public emergence of this community was manifest at a conference held in June 1949 titledActivity Analysis of Production and Allocation. New ideas in optimization theory, linked to linear programming, developed from the conference's papers. The authors’ history of this event situates the Cowles Commission among the institutions of postwar science in-between National Laboratories and the supreme discipline of Cold War academia, mathematics. Although the conference created the conditions under which economics, as a discipline, would transform itself, the participants themselves had little concern for the intellectual battles that had defined prewar university economics departments. The authors argue that the conference signaled the birth of a new intellectual culture in economic science based on shared scientific norms and techniques un-interrogated by conflicting notions of the meaning of either science or economics.
Making Organisms Model Human Behavior: Situated Models in North-American Alcohol Research, since 1950
Authors: Ankeny Rachel A. , Leonelli Sabina , Nelson Nicole C. , Ramsden Edmund 
Published: July 2014

ArgumentWe examine the criteria used to validate the use of nonhuman organisms in North-American alcohol addiction research from the 1950s to the present day. We argue that this field, where the similarities between behaviors in humans and non-humans are particularly difficult to assess, has addressed questions of model validity by transforming the situatedness of non-human organisms into an experimental tool. We demonstrate that model validity does not hinge on the standardization of one type of organism in isolation, as often the case with genetic model organisms. Rather, organisms are viewed as necessarily situated: they cannot be understood as a model for human behavior in isolation from their environmental conditions. Hence the environment itself is standardized as part of the modeling process; and model validity is assessed with reference to the environmental conditions under which organisms are studied.
An Uncertain Risk: The World Health Organization's Account of H1N1
Authors: Abeysinghe Sudeepa 
Published: July 2014

ArgumentScientific uncertainty is fundamental to the management of contemporary global risks. In 2009, the World Health Organization (WHO) declared the start of the H1N1 Influenza Pandemic. This declaration signified the risk posed by the spread of the H1N1 virus, and in turn precipitated a range of actions by global public health actors. This article analyzes the WHO's public representation of risk and examines the centrality of scientific uncertainty in the case of H1N1. It argues that the WHO's risk narrative reflected the context of scientific uncertainty in which it was working. The WHO argued that it was attempting to remain faithful to the scientific evidence, and the uncertain nature of the threat. However, as a result, the WHO's public risk narrative was neither consistent nor socially robust, leading to the eventual contestation of the WHO's position by other global public health actors, most notably the Council of Europe. This illustrates both the significance of scientific uncertainty in the investigation of risk, and the difficulty for risk managing institutions in effectively acting in the face of this uncertainty.
Shifting Expert Configurations and the Public Credibility of Science: Boundary Work and Identity Work of Hydraulic Engineers (1980–2009)
Authors: van Rijswoud Erwin 
Published: July 2014

ArgumentIn the Netherlands, a country of water, dikes, and dams, the role of civil engineering in policy making and public debates over flood safety have changed over the last four decades. This had not just implied that new directions in flood safety policy were considered by politics, but also that engineering experts traditionally working in this area found their credibility challenged by competing expertises. I will argue that in responding to those challenges, experts combined boundary work (upholding boundaries between science and non-science, or between different fields of expertise) with identity work, in which the planning of actions and learning from experience are informed by the identity of oneself as an expert. The views of experts on the boundary zone of science, policy, and public debate, and the role and skills one attributes to oneself, are regarded as important aspects of that identity work. On the basis of biographical-narrative research, this will show that although the four experts studied here belong to a specific generation of engineers, experiencing common challenges and developments in their field of work, the combination of identity work and boundary work results in specific roles and responses for each individual expert.
The syllabic status of final consonants in early speech: a case study
Authors: YUEN IVAN , MILES KELLY , COX FELICITY , DEMUTH KATHERINE 
Published: July 2014

ABSTRACTYoung children's first attempts at CVC words are often realized with the final consonant being heavily aspirated or followed by an epenthetic vowel (e.g. cat /kæt/ realized as [kæth] or [kætə]). This has led some to propose that young children represent word-final (coda) consonants as an onset-nucleus sequence (CV.Cv) (e.g. Goad & Brannen, 2003), raising questions about the syllabic status of the final consonant. To address this issue, we conducted an acoustic analysis of a child's early production of CVC, CVCh, and CVCV words between the ages of 1;3 and 1;5. Aside from aspiration, the results showed that there were no significant acoustic differences between the CVC and CVCh forms. In contrast, there were systematic acoustic differences in C2 closure duration between the CVC/CVCh and CVCV target words, suggesting that at least some children learning English have early coda representations for monosyllabic CVC words, whether heavily aspirated or not.
Does Interviewer Religious Dress Affect Survey Responses? Evidence from Morocco
Authors: Benstead Lindsay J. 
Published: July 2014

AbstractFew studies examine religiosity-of-interviewer effects, despite recent expansion of surveying in the Muslim world. Using data from a nationally-representative survey of 800 Moroccans conducted in 2007, this study investigates whether and why interviewer religiosity and gender affect responses to religiously-sensitive questions. Interviewer dress affects responses to four of six items, but effects are larger and more consistent for religious respondents, in support of power relations theory. Religious Moroccans provide less pious responses to secular-appearing interviewers, whom they may link to the secular state, and more religious answers to interviewers wearing hijab, in order to safeguard their reputation in a society that values piety. Interviewer traits do not affect the probability of item-missing data. Religiosity-of-interviewer effects depend on interviewer gender for questions about dress choice, a gendered issue closely related to interviewer dress. Interviewer gender and dress should be coded and controlled for to reduce bias and better understand social dynamics.