bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis of Human Mesenchymal Stem Cells Derived From Bone Marrow, Placenta, and Adipose Tissue as Sources of Cell Therapy
Authors: Jeon Young‐Joo , Kim Jumi , Cho Jin Hyoung , Chung Hyung‐Min , Chae Jung‐Il 
Published: October 2015

ABSTRACTVarious source‐derived mesenchymal stem cells (MSCs) with multipotent capabilities were considered for cell therapeutics of incurable diseases. The applicability of MSCs depends on the cellular source and on their different in vivo functions, despite having similar phenotypic and cytological characteristics. We characterized MSCs from different sources, including human bone marrow (BM), placenta (PL), and adipose tissue (AT), in terms of the phenotype, surface antigen expression, differentiation ability, proteome reference map, and blood flow recovery in a hindlimb ischemic disease model. The MSCs exhibit different differentiation potentials depending on the cellular source despite having similar phenotypic and surface antigen expression. We identified approximately 90 differentially regulated proteins. Most up‐ or down‐regulated proteins show cytoskeletal or oxidative stress, peroxiredoxin, and apoptosis roles according to their functional involvement. In addition, the PL‐MSCs retained a higher therapeutic efficacy than the BM‐ and AT‐MSCs in the hindlimb ischemic disease model. In summary, we examined differentially expressed key regulatory factors for MSCs that were obtained from several cellular sources and demonstrated their differentially expressed proteome profiles. Our results indicate that primitive PL‐MSCs have biological advantages relative to those from other sources, making PL‐MSCs a useful model for clinical applications of cell therapy. J. Cell. Biochem. 117: 1112–1125, 2016. © 2015 Wiley Periodicals, Inc.
Incretinomimetic and Insulinomimetic Effect of (2E)‐N′‐(1′‐Naphthyl)‐3,4,5‐Trimethoxybenzohydrazide for Glycemic Homeostasis
Authors: Silva Frederico Marisa Jádna , Mascarello Alessandra , Castro Allisson Jhonatan Gomes , Da Luz Gabrielle , Altenhofen Delsi , Mendes Camila Pires , Leal Paulo Cesar , Yunes Rosendo Augusto , Nunes Ricardo José , Silva Fátima Regina Mena Barreto 
Published: October 2015

ABSTRACTTo characterize the role and the mechanism of action of (2E)‐N′‐(1′‐naphthyl)‐3,4,5‐trimethoxybenzohydrazide (BZD) on incretin secretion, glucose uptake in skeletal muscle and α‐glucosidase activity on intestine, targets for glucose homeostasis. It was assayed on glucose tolerance test (GTT) to analyze GLP‐1 secretion and the activity of DPP‐4 enzyme in vitro. In skeletal muscle, mechanism of action on glucose uptake was carried out by in vitro experiments. The activity of intestinal disaccharidases was performed after in vivo and in vitro experiments. The compound improved the glucose tolerance around 30%, 25%, and 20% at 15, 30, and 60 min, respectively and potentiated the sitagliptin effect, an inhibitor of the enzyme that removes GLP‐1, about 50, 45, and 54% at 15, 30, and 60 min, respectively. Additionally, BZD did not modify the activity of DPP‐4 enzyme. The acute effect of BZD on glucose uptake is mediated by increasing GLUT4 expression (around 140%) and its translocation to the plasma membrane in soleus muscle. The genomic effect as well as GLUT4 translocation involve the activation of PI‐3K and MAPK pathways and require the microtubules integrity to the complete stimulatory effect of this compound on glucose uptake. Beyond, BZD acts in an alternative target to ameliorate glycaemia, intestinal disaccharidases. In a whole, these data point an incretino‐ and insulinomimetic effect of the compound for glycemic control. J. Cell. Biochem. 117: 1199–1209, 2016. © 2015 Wiley Periodicals, Inc.
Incorporating Resilience Factors Into the Interpersonal Theory of Suicide: The Role of Hope and Self‐Forgiveness in an Older Adult Sample
Authors: Cheavens Jennifer S. , Cukrowicz Kelly C. , Hansen Ryan , Mitchell Sean M. 
Published: October 2015

ObjectivesThe interpersonal theory of suicide posits that perceived burdensomeness and thwarted belongingness are risk factors for suicide ideation. To more comprehensively characterize this model, it is important to identify resilience factors. Forgiveness of oneself may attenuate the relation between perceived burdensomeness and suicide ideation. Similarly, hope might weaken the association between thwarted belongingness and suicide ideation.MethodWe examined these relations cross‐sectionally in a sample (N = 91) of older adults after including symptoms of depression and demographic variables in the models.ResultsSelf‐forgiveness moderated the relation between perceived burdensomeness and suicide ideation. Hope did not moderate the relation between thwarted belongingness and suicide ideation.ConclusionsThese findings suggest that including resilience factors (i.e., self‐forgiveness) in models of suicide ideation may result in better identification of those most at risk for suicide and may allow for more precise intervention targets.
Enhancing fixation strength in periprosthetic femur fractures by orthogonal plating—A biomechanical study
Authors: Lenz Mark , Stoffel Karl , Gueorguiev Boyko , Klos Kajetan , Kielstein Heike , Hofmann Gunther O. 
Published: October 2015

ABSTRACTOrthogonal plate osteosynthesis enhances fixation stability in periprosthetic femur fractures. Another option are locking attachment plates (LAP) allowing bicortical locking screw placement lateral to the prosthesis stem. Stability of lateral plate osteosynthesis with two LAP (2LAP) was compared to anterolateral orthogonal plate osteosynthesis (OP) with one LAP in a periprosthetic femur fracture model. In six pairs of fresh frozen human femora with cemented Charnley hip prosthesis, a transverse osteotomy was set distal to the tip of the prosthesis simulating a Vancouver type B1 fracture. Each pair was instrumented using a plate tensioner with either one lateral plate and two LAP, or two orthogonal anterolateral plates and one LAP. Stiffness was determined in a four‐point‐bending test prior to cyclic testing (2Hz) with physiologic profile and progressively increasing load up to catastrophic construct failure. Paired t‐test and Wilcoxon‐signed‐rank test were used for statistical evaluation at a level of significance p = 0.05. The OP construct exhibited a significantly higher number of cycles and load to failure (39,627 cycles ± 4,056; 4,463 N ± 906) compared to the 2LAP construct (32,927 cycles ± 3,487; 3,793 N ± 849), p < 0.01. Mediolateral bending and torsional stiffness of the OP (1610 N/mm ± 249; 16.9 Nm/mm ± 6.3) were significantly higher compared to 2 LAP (1077 N/mm ± 189; 12.1 Nm/mm ± 3.9), p = 0.03 for both comparisons. Orthogonal plate osteosynthesis is a valuable option in periprosthetic fracture surgery, offering increased stability compared to a single lateral plate fixed with two LAP. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:591–596, 2016.
Evaluating sources of censoring and truncation in telemetry‐based survival data
Authors: DeCesare Nicholas J. , Hebblewhite Mark , Lukacs Paul M. , Hervieux David 
Published: October 2015

ABSTRACTBias in vital rate estimation may come from failing to meet a variety of assumptions during the stages of sampling, monitoring, and analysis, though most are not commonly addressed in published studies. Here, we pay specific attention to various forms of censoring and truncation that present challenges for telemetry‐based monitoring of survival. We use simulations to assess how uncertainty about times of death and imperfect detection probabilities affect Kaplan–Meier survival estimates. We then treat monitoring of threatened woodland caribou (Rangifer tarandus caribou) in west‐central Alberta as a case study to test for potential effects of non‐random right censoring and interval censoring on survival estimates. We report that monitoring frequency (e.g., daily vs. monthly) and associated uncertainty about the exact time of death do not inherently induce bias on Kaplan–Meier point estimates of survival nor affect estimates of variance. Removing individuals from the at‐risk pool during intervals for which they were not detected did induce a negative bias on resulting survival estimates when the probability of detection was independent of the animals' fates. We recommend using subsequent detections to impute animals' fates during missed intervals in such cases when all animals' fates are eventually known or permanently right censored and when missed detections are not related to changes in mortality risk. Although some assumptions remain difficult to test and of continued concern, we find no evidence of biases in the methodology of Alberta's woodland caribou monitoring program. Our results lend credence to recent evidence of widespread declines in woodland caribou populations across the province. © 2015 The Wildlife Society.
Dietary folate, one‐carbon metabolism‐related genes, and gastric cancer risk in Korea
Authors: Kim Woori , Woo Hae Dong , Lee Jeonghee , Choi Il Ju , Kim Young Woo , Sung Joohon , Kim Jeongseon 
Published: October 2015

ScopeWe evaluated the interactions between polymorphisms involved in one‐carbon metabolism‐related genes and dietary folate intake in gastric cancer risk within the Korean population through a hospital‐based case‐control study.Methods and resultsA total of 542 controls and 271 cases were included. Genotype data were selected from data produced by the Affymetrix Axiom® Exome 319 Array. We considered seven single nucleotide polymorphisms (SNPs) of five genes whose SNPs are located in the coding region with a minor allele frequency > 5%: MTHFR (G1793A, A1298C, C677T), MTR A2756G, MTRR A66G, SHMT1 C1420T, and SLC19A1 G80A. Our study found that MTR A2756G was associated with a decreased gastric cancer risk. MTHFR G1793A showed a statistically significant interaction between dietary folate intake and gastric cancer.ConclusionOur results suggest that MTR A2756G is significantly associated with gastric cancer risk, and that MTHFR G1793A statistically interacts with dietary folate intake. Our findings indicate that gene–folate interactions may contribute to gastric cancer risk.
Novel stilbene‐based Fischer base analog of leuco‐TAM – (2E,2′Z)‐{2‐(4‐(E)‐styrylphenyl)propane‐1,3‐diylidene}bis(1,3,3‐trimethylindoline) – derivatives: synthesis and structural consideration by 1D NMR and 2D NMR spectroscopy
Authors: Keum Sam‐Rok , Lim Hyun‐Woo 
Published: October 2015

AbstractWe report the synthesis of a series of novel stilbene‐based (St) Fischer base analogs of leuco‐triarylmethane (LTAM) dyes by treating Fischer base with (E)‐4‐styrylbenzaldehyde derivatives. All St‐LTAM molecules examined herein are characterized by 1D and 2D NMR. They were found to exhibit ZE configuration and isomerize to their diastereomers EE and ZZ in 2–3 h. They exhibit type I behavior of diastereomeric isomerization. Copyright © 2015 John Wiley & Sons, Ltd.
Tests for homogeneity of distributions of component lifetimes from system lifetime data with known system signatures
Authors: Zhang Jian , Tony Ng Hon Keung , Balakrishnan Narayanaswamy 
Published: October 2015

AbstractIn this article, we discuss the problem of testing the homogeneity of distributions of component lifetimes based on system lifetime data when the system signatures are known. Both parametric and nonparametric procedures are developed for this problem. For nonparametric testing, the Mann–Whitney‐type statistic is used, and its performance and limitations are discussed. Next, we assume the component lifetimes to follow exponential distributions and then develop different parametric tests. Exact and asymptotic methods are developed based on the method of moments estimators. A Monte Carlo simulation study is used to compare the performance of different parametric procedures with that of the nonparametric procedure. Based on the results of the simulation study, discussions and practical recommendations are made and finally some concluding remarks are provided. © 2015 Wiley Periodicals, Inc. Naval Research Logistics 62: 550–563, 2015
In Brief: Endothelial‐to‐mesenchymal transition
Authors: Sanchez‐Duffhues Gonzalo , Orlova Valeria , ten Dijke Peter 
Published: October 2015

AbstractRecent evidence has highlighted the role of endothelial‐to‐mesenchymal transition (EndoMT) in the onset and progression of a number of human pathologies. EndoMT involves the loss of an endothelial signature to generate unspecialized mesenchymal‐like cells, susceptible to being re‐differentiated into mesodermal cell types, including osteoblasts, chondrocytes, and adipocytes. Therefore, modulation of the molecular pathways controlling EndoMT can be considered as a therapeutic approach for particular human diseases. In addition, EndoMT may be harnessed for tissue engineering by producing multipotent mesenchymal cells able to differentiate into mutiple cell types. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Investigation of mechanical properties of porous composite scaffolds with tailorable degradation kinetics after in vitro degradation using digital image correlation
Authors: Idaszek J. , Brynk T. , Jaroszewicz J. , Vanmeert F. , Bruinink A. , Święszkowski W. 
Published: October 2015

Tissue engineering combines artificial scaffolds and living cells in order to reconstruct damaged tissues and organs. The biodegradable scaffolds should maintain their mechanical properties during first stages of the regeneration. The aim of this study was to investigate the extent the degradation affects the mechanical stability of novel biodegradable composite scaffolds in relation to their composition. The scaffolds were made using fused deposition modeling. They were composed of ternary composites containing poly(ε‐caprolactone) (PCL), 5 wt% of tricalcium phosphate (TCP) and 5, 15, and 25 wt% of poly(lactide‐co‐glycolide) (PLGA). Scaffolds made of pristine PCL and binary composite PCL–TCP were tested as reference samples. The degradation experiment was carried out in simulated body fluid at 37°C for 12 weeks. Mechanical tests were carried out in a mechanical tester. Strain was measured using digital image correlation and crossbar displacement. Chemical composition had a significant effect on initial mechanical properties and their changes during degradation. The initial apparent Young's modulus of ternary composite scaffolds was two times higher than that of PCL–TCP. Higher PLGA concentration yielded faster decrease of the mechanical properties. At the end of the experiment, there were no significant differences of the modulus among all tested materials although degradation of the ternary composite scaffolds was significantly advanced. POLYM. COMPOS., 38:2402–2410, 2017. © 2015 Society of Plastics Engineers
Determination of the Velocity Difference between Jet Fragments for a Range of Copper Liners with Different Small Grain Sizes
Authors: Elshenawy Tamer 
Published: October 2015

AbstractA range of small calibre shaped charge copper liners were manufactured experimentally by the electro‐deposition technique. The average grain size of the produced copper liners was determined using the SEM technique. The specific breakup time, which represents the velocity difference between the particulated jet neighboring fragments (VPL), was determined for the range of copper liners of different grain sizes using Zerelli‐Armstrong constitutive model. The specific breakup time and the total number of the jet fragments were studied over the range of grain size and the predicted jet temperature.
Emulation and Calculation of the Burning Surface of 3D Grains of Partially Cut Multi‐Perforated Stick Propellant using the Level Set Method
Authors: Xiao Zhenggang , He Weidong , Xu Fuming 
Published: October 2015

AbstractIn order to calculate the burnt mass fraction of complex three‐dimensional (3D) propellant grains to meet the requirements of interior ballistic modelling; the level set method is introduced to emulate and calculate the burning surface area of partially cut 7‐perforated propellant. The surface evolution and simulation of a 3D grain of partially cut 7‐perforated propellant are divided into two parts: the grain configuration initialization and the level set calculation of the propellant regression process. Parallel layer burning is assumed so that the burning surface regresses layer by layer in a direction normal to the surface until the grain is burnt completely. As the burnt mass fraction increases, the remaining propellant volume decreases gradually. The level set method easily simulates the slivering process for complex grain geometries. In this way, the burnt mass fraction of partially cut 7‐perforated propellant grain can be calculated by the level set method for the entire combustion process. Results show that the level set method is suitable to capture the burning surface for each burning step and its related parameters, such as the burning area, the remaining propellant volume and burnt mass fraction. More importantly, the level set method gives a possible solution to the coupling of grain combustion with the internal fluid simulation by the pressure and velocity. It is impossible for geometry‐based methods to integrate the internal fluid parameters in an interior ballistic model. Also, the level set method will benefit substantially the grain design and lead to improved internal ballistic performance.
Two Fungal Infections of Inflatable Penile Prostheses in Diabetics
Authors: Cotta Brittney H. , Butcher Michael , Welliver Charles , McVary Kevin , Köhler Tobias 
Published: October 2015

Abstract

Introduction
Penile prosthesis infections have decreased since the introduction of antibiotic-coated implants. Infections that do occur can be from more rare and virulent organisms than the traditional skin flora historically implicated.

Aim
In this report, we present two cases of inflatable penile prosthesis (IPP) infection from Candida organisms in insulin-dependent diabetic patients.

Methods
Case report with literature review.

Main Outcome Measures
Resolution of the two cases.

Results
Both patients were found to have insulin-dependent diabetes. Both patients also presented with infection of the device with Candida species, with the implant pump adherent to their scrotal skin.

Conclusions
This report supports the emerging literature that the flora of IPP infections is changing. We suggest considering adding antifungal agents to antibiotic coatings, dips, or washout solutions at the time of penile prosthesis surgery in diabetic patients.
Retrospective Analysis of Clinical Features, Treatment and Outcome of Coital Injuries of the Female Genital Tract Consecutive to Consensual Sexual Intercourse in the Limbe Regional Hospital
Authors: Tchounzou Robert , Chichom-Mefire Alain 
Published: October 2015

AbstractIntroductionNonobstetrical genital injuries are gradually becoming a common cause of genital injuries. Consensual sex has been reported to be a possible cause of this type of injuries, but its contribution to traumatic lesions of the female genital tract is not well known. It has been suggested that injury consecutive to consensual sex can be extensive and life-threatening.AimThe aim of this study was to analyze the clinical features, treatment modalities, and the outcome of injuries to the female genital tract consecutive to a consensual sexual intercourse.MethodsA retrospective review of records of female patients admitted in our institution with a complaint of genital injury over a 5-year period. We collected data regarding patient and injury characteristics, findings of the gynecologic examination, modalities of management and final outcome.Main Outcome MeasuresAnatomic location and nature of injury, modalities of management, admission rate and mortality rate.ResultsForty six cases could be analyzed. Their mean age was 25.6 years. Almost 35% of patients sustained the injury during their first sexual contact. The majority presented with bleeding, often combined with pain. One patient presented with features of peritonitis. During examination, no anatomic lesions could be identified in 16 (34.8%) of patients. When a lesion was present, it concerned mostly the posterior fornix (28.3%) and the lateral vaginal wall (10%). The most frequently described lesion was a laceration. The majority of patients (83%) were treated with suturing under local anesthesia. The admission rate was 28%, and was significantly higher in patients with a laceration of the posterior fornix. No death was recorded.ConclusionsCoital injuries following consensual sex often present in the form of a life-threatening condition and young female with no previous sexual experience are particularly exposed. Most lesions can be treated with a simple suture.
Long‐term cognitive follow‐up in children treated for Maroteaux‐Lamy syndrome
Authors: Ebbink Berendine J. , Brands Marion M. G. , den van Hout Johanna M. P. , Lequin Maarten H. , den van Braak Robert R. J. Coebergh , van de Weitgraven Rianne L. , Plug Iris , Aarsen Femke K. , van der Ploeg Ans T. 
Published: October 2015

AbstractBackgroundIt remains unclear to what extent the brain is affected by Maroteaux‐Lamy syndrome (MPS VI), a progressive lysosomal storage disorder. While enzyme replacement therapy (ERT) elicits positive effects, the drug cannot cross the blood–brain barrier. We therefore studied cognitive development and brain abnormalities in the Dutch MPS VI patient population treated with ERT.MethodsIn a series of 11 children with MPS VI (age 2 to 20 years), we assessed cognitive functioning and brain magnetic resonance imaging prospectively at the start of ERT and at regular times thereafter up to 4.8 years. We also assessed the children's clinical characteristics, their siblings’ cognitive development, and their parents’ educational levels.ResultsThe patients’ intelligence scores ranged from normal to mentally delayed (range test scores 52–131). In 90 %, their scores remained fairly stable during follow‐up, generally lying in the same range as their siblings’ test scores (median for patients = 104, median for siblings = 88) and comparing well with the parental educational levels. Native‐speaking patients had higher intelligence test scores than non‐native‐speaking patients. Two patients, both with high baseline glycosaminoglycan levels in their urine and severe mutations in the arylsulfatase B gene, scored clearly lower than expected. Patients with pY210C performed best. Brain abnormalities were aspecific, occurring more in patients with severe symptoms.ConclusionOur study shows that cognitive development in MPS VI patients is determined not only by familial and social‐background factors, but, in patients with a severe form of the disease, also by the disease itself. Therefore in patients with severe disease presentation cognition should be monitored carefully.