bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymmetric Hydrogenation of β‐Keto Sulfonamides and β‐Keto Sulfones with a Chiral Cationic Ruthenium Diamine Catalyst
Authors: Huang Xiao‐Fei , Zhang Shao‐Yun , Geng Zhi‐Cong , Kwok Chun‐Yuen , Liu Peng , Li Hai‐Yan , Wang Xing‐Wang 
Published: October 2013

AbstractOptically active β‐hydroxy sulfonamides and β‐hydroxy sulfones are very important building blocks for the preparation of bioactive compounds and pharmaceuticals. In this work, a highly efficient asymmetric hydrogenation of β‐keto sulfonamides and β‐keto sulfones has been developed using the phosphine‐free chiral ruthenium complex Ru(OTf)(TsDPEN)(η6‐p‐cymene) as the catalyst, to afford the corresponding β‐hydroxy sulfonamides and β‐hydroxy sulfones in high yields with excellent optical purities. In addition, a cascade asymmetric hydrogenation/dynamic kinetic resolution (DKR) of racemic cyclic β‐keto sulfonamides and β‐keto sulfones was also realized using the same catalyst, to give the corresponding chiral cyclic β‐hydroxy sulfonamides and β‐hydroxy sulfones in good yields with excellent enantio‐ and diastereoselectivities.magnified image
Copper‐Catalyzed Domino Synthesis of 4‐Oxopyrimido[1,2‐a]indole Derivatives
Authors: Wang Yuyuan , Wang Ruji , Jiang Yuyang , Tan Chunyan , Fu Hua 
Published: October 2013

AbstractA novel, convenient and efficient copper‐catalyzed domino method for the synthesis of 4‐oxopyrimido[1,2‐a]indole derivatives has been developed, and the corresponding target products were obtained in moderate to good yields. The domino reactions involved sequential copper‐catalyzed intermolecular C‐arylation, intramolecular addition of NH to nitrile and nucleophilic attack of amino to carbonyl, and the obtained N‐(2‐halophenyl)‐3‐oxoalkanamides carry various functional groups.magnified image
Efficient Indirect Electrochemical Synthesis of 2‐Substituted Benzoxazoles using Sodium Iodide as Mediator
Authors: Li Wei‐Cui , Zeng Cheng‐Chu , Hu Li‐Ming , Tian Hong‐Yu , Little R. Daniel 
Published: October 2013

AbstractAn electrochemical strategy for the efficient synthesis of 2‐substituted benzoxazoles was developed using a catalytic amount of sodium iodide (NaI) as a redox catalyst in a two‐phase buffer system.magnified image
Magnetic Nanoparticles (CoFe2O4)‐Supported Phosphomolybdate as an Efficient, Green, Recyclable Catalyst for Synthesis of β‐Hydroxy Hydroperoxides
Authors: Li Pei‐He , Li Bao‐Le , An Zhi‐Min , Mo Li‐Ping , Cui Zhen‐Shui , Zhang Zhan‐Hui 
Published: October 2013

AbstractMagnetic nanoparticles (CoFe2O4)‐supported phosphomolybdate ([CoFe2O4@SiO2‐PrNH2‐PMo]) was readily prepared and identified as an efficient catalyst for ring‐opening of various epoxides with ethereal hydrogen peroxide (H2O2). The reaction proceeded under mild conditions to give β‐hydroxy hydroperoxides (HHPs) in high yields at room temperature, and the catalyst could be magnetically separated and recycled.magnified image
N,N′‐Dioxide–Scandium(III)‐Catalyzed Asymmetric Michael Addition of β,γ‐Unsaturated Butenolides to α,β‐Unsaturated γ‐Keto Esters
Authors: Ji Jie , Lin Lili , Zhou Lin , Zhang Yuheng , Liu Yangbin , Liu Xiaohua , Feng Xiaoming 
Published: October 2013

AbstractA highly efficient N,N′‐dioxide–scandium(III) complex catalytic system has been developed for the asymmetric vinylogous Michael reaction of α‐angelica lactone and its derivatives to α,β‐unsaturated γ‐keto esters, affording the corresponding γ,γ‐disubstituted butenolide products in moderate to good yields (up to 93%) with high dr (up to >19:1) and ee values (up to 97%) under mild reaction conditions.magnified image
Asymmetric Hydrogenation of Quinoxalines, Benzoxazines, and a Benzothiazine Catalyzed by Chiral Ruthenabicyclic Complexes
Authors: Arai Noriyoshi , Saruwatari Yu , Isobe Kotaro , Ohkuma Takeshi 
Published: October 2013

AbstractThe ruthenabicyclic complex RuCl[(R)‐daipena][(R)‐dm‐segphos] with potassium tert‐butoxide catalyzes the hydrogenation of 2‐alkylquinoxalines and a 3‐methyl‐2H‐1,4‐benzoxazine in toluene under 20–100 atm of hydrogen at 40 °C to afford S‐configured cyclic amino products in greater than 97% enantiomeric excess {DAIPENA=anion of DAIPEN at the 2‐position of an anisyl group, DAIPEN=1,1‐di(4‐anisyl)‐2‐isopropyl‐1,2‐ethylenediamine, DM‐SEGPHOS=(4,4′‐bi‐1,3‐benzodioxole)‐5,5′‐diylbis[di(3,5‐xylyl)phosphine]}. The high catalytic activity results in a turnover number as high as 9400. Hydrogenation of the benzoimine heterocycles with the RuCl[(R)‐daipena][(R)‐segphos]/potassium tert‐butoxide system yields the R‐configured products in high enantiomeric excess [SEGPHOS=(4,4′‐bi‐1,3‐benzodioxole)‐5,5′‐diylbis(diphenylphosphine)]. The mode of enantioselection is discussed based on transition state models involving six‐membered pericyclic structures.magnified image
Vinylogous Organocatalytic Triple Cascade Reaction: Forging Six Stereocenters in Complex Spiro‐Oxindolic Cyclohexanes
Authors: Chatterjee Indranil , Bastida David , Melchiorre Paolo 
Published: October 2013

AbstractWe report a triple vinylogous cascade reaction, yielding valuable spiro‐oxindolic cyclohexane derivatives. The three‐component domino process proceeds by way of a catalyzed Michael/1,6‐addition/vinylogous aldol sequence affording the products with six stereogenic centers and very high control over the stereochemistry. The chemistry is based on a rare example of asymmetric 1,6‐addition to linear 2,4‐dienals proceeding with complete δ‐site selectivity. Key to the reaction development was a directing group positioned at the β‐dienal position, which was essential for achieving highly predictable reaction outcomes.magnified image
Photoredox Catalysis for Organic Syntheses
Authors: Reckenthäler Melissa , Griesbeck Axel G. 
Published: October 2013

AbstractCurrent examples of photoredox catalytic processes for CO, CN, CHal and CC bond formation are described with emphasis on the basic mechanistic scenarios. The focus is on the special aspects of photochemical redox catalysis especially on the electron transfer energetics, the use of electron transfer (ET) sensitizers and mediators as well as sacrificial reagents.magnified image
Achieving Efficiency and Equity in Sugar Factories and Sugar‐Cropping Patterns Under Climate Change in Upper and Middle Egypt
Authors: Hamada Youssef M. 
Published: October 2013

ABSTRACTDrought as a natural phenomenon, due to variability of meteorological conditions, strikes worldwide but the severity of its impact depends on the vulnerabilities of water supply systems and economical and sectors as well as on the effectiveness of the adopted mitigation measures. The aim of this paper is to study achieving efficiency and equity in sugar factories and sugar‐cropping patterns in Upper and Middle Egypt by focusing on the Strategic Water Shortage Preparedness Plan, introduction methodologies, and specific action to fight drought within the general water‐planning framework. The Linear Programming Model was applied to calculate the sugar crops, sugar cane and sugar beet acreage, production, and income of both Upper and Middle Egypt. As a result of an optimal cropping pattern, the cultivation season would lose acreage by 7.260%, farm income increase by 1.774%, water uses decrease by 18.511%, and CO2emission and energy reduced by 14.96%. Overall, as a result of an optimal sugar‐cropping pattern, Egyptian sugar exports would decrease by $130.086 million US. [EconLit classification: Q130 and Q000].
Tightening methods for continuous‐time mixed‐integer programming models for chemical production scheduling
Authors: Merchan Andres F. , Velez Sara , Maravelias Christos T. 
Published: October 2013

SignificanceImportant advances in modeling chemical production scheduling problems have been made in recent years, yet effective solution methods are still required. We use an algorithm that uses process network and customer demand information to formulate powerful valid inequalities that substantially improve the solution process. In particular, we extend the ideas recently developed for discrete‐time formulations to continuous‐time models and show that these tightening methods lead to a significant decrease in computational time, up to more than three orders of magnitude for some instances. © 2013 American Institute of Chemical Engineers AIChE J, 59: 4461–4467, 2013
Retracted: Joined at the hip? A paleoepidemiological study of developmental dysplasia of the hip and its relation to swaddling practices among indigenous peoples of North America
Authors: Blatt Samantha H. 
Published: October 2013

ABSTRACTThe above article, published online on 7 October 2013 in Wiley Online Library (wileyonlinelibrary.com), and in Volume 25, No. 6, pp. 821–834, November/December 2013, has been retracted by agreement between the author, the journal Editor‐in‐Chief, and Wiley Periodicals, Inc. The retraction has been agreed due to unattributed use of methodological statements and diagnostic criteria from “Brief communication: Developmental dysplasia of the hip in medieval London” by Piers D. Mitchell and Rebecca C. Redfern (American Journal of Physical Anthropology 144:3, March 2011, doi: 10.1002/ajpa.21448), from which Figure 1 was also adapted without proper acknowledgement, and from “Diagnostic criteria for developmental dislocation of the hip in human skeletal remains” by P.D. Mitchell and R.C. Redfern (International Journal of Osteoarchaeology 18:1, January/February 2008, doi: 10.1002/oa.919).
Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults
Authors: Thompson Amanda L. , Houck Kelly M. , Adair Linda , Gordon‐Larsen Penny , Du Shufa , Zhang Bing , Popkin Barry 
Published: October 2013

AbstractObjectivesInfluenced by pathogen exposure and obesity, inflammation provides a critical biological pathway linking changing environments to the development of cardiometabolic disease. This study tests the relative contribution of obesogenic and pathogenic factors to moderate and acute CRP elevations in Chinese children, adolescents and adults.MethodsData come from 8795 participants in the China Health and Nutrition Study. Age‐stratified multinomial logistic models were used to test the association between illness history, pathogenic exposures, adiposity, health behaviors and moderate (1–10 mg/L in children and 3–10 mg/L in adults) and acute (>10mg/L) CRP elevations, controlling for age, sex and clustering by household. Backward model selection was used to assess which pathogenic and obesogenic predictors remained independently associated with moderate and acute CRP levels when accounting for simultaneous exposures.ResultsOverweight was the only significant independent risk factor for moderate inflammation in children (RRR 2.10, 95%CI 1.13‐3.89). History of infectious (RRR 1.28, 95%CI 1.08‐1.52) and non‐communicable (RRR 1.37, 95%CI 1.12‐1.69) disease, overweight (RRR 1.66, 95%CI 1.45‐1.89) and high waist circumference (RRR 1.63, 95%CI 1.42‐1.87) were independently associated with a greater likelihood of moderate inflammation in adults while history of infectious disease (RRR 1.87, 95%CI 1.35‐2.56) and overweight (RRR 1.40, 95%CI 1.04‐1.88) were independently associated with acute inflammation. Environmental pathogenicity was associated with a reduced likelihood of moderate inflammation, but a greater likelihood of acute inflammation in adults.ConclusionsThese results highlight the importance of both obesogenic and pathogenic factors in shaping inflammation risk in societies undergoing nutritional and epidemiological transitions. Am. J. Hum. Biol. 26:18–28, 2014. © 2013 Wiley Periodicals, Inc.
Predictors for return to work for those with occupational respiratory disease: Clinical and structural factors
Authors: Zoeckler Jeanette M. , Cibula Donald A. , Morley Christopher P. , Lax Michael B. 
Published: October 2013

AbstractBackgroundFew occupational researchers have examined “return to work” among patients with work‐related respiratory diseases. In addition, prior studies have emphasized individual patient characteristics rather than a more multi‐dimensional approach that includes both clinical and structural factors.MethodsA retrospective chart review identified patients with occupational respiratory diseases in the Occupational Health Clinical Center, Syracuse, NY between 1991 and 2009. We assessed predictors of work status using an exploratory, sequential mixed methods research design, multinomial (n = 188) and Cox regressions (n = 130).ResultsThe findings suggest that patients with an increased number of diagnoses, non‐union members, and those who took more than a year before clinical presentation had significantly poorer work status outcomes, after adjusting for age, education level, and relevant diagnoses.ConclusionsEfforts to prevent slow return to work after developing occupational respiratory disease should recognize the importance of timely access to occupational health services, disease severity, union membership, and smoking status. Am. J. Ind. Med. 56:1371–1382, 2013. © 2013 Wiley Periodicals, Inc.
Investigation of respiratory and dermal symptoms associated with metal working fluids at an aircraft engine manufacturing facility
Authors: Meza Francisco , Chen Lilia , Hudson Naomi 
Published: October 2013

AbstractBackgroundEach year, 1.2 million metalworkers are exposed to metalworking fluids (MWFs), which can cause dermal and respiratory disease. The National Institute for Occupational Safety and Health (NIOSH) conducted a health hazard evaluation of MWF exposures at an aircraft engine manufacturing facility. The objectives were to determine employee exposures to endotoxin and MWFs in the air, characterize symptoms experienced by employees working with MWFs, compare them to symptoms of employees unexposed to MWFs, and make recommendations for reducing exposures based on results.MethodsFour hundred seven workers were categorized as MWF exposed or MWF unexposed and completed questionnaires. Estimated prevalence ratios (PR) of dermatitis, asthma, and work‐related asthma (WRA) symptoms were calculated. Airborne concentrations of MWF and endotoxin were measured, and work practices observed.ResultsMWF exposed workers had a significantly higher prevalence of dermatitis on wrists/forearms (PR 2.59; 95% CI 1.22, 5.46), asthma symptoms (PR 1.49; 95% CI 1.05, 2.13), and WRA symptoms (PR 2.10; 95% CI 1.22, 3.30) than unexposed workers. Airborne concentrations of MWF were below the NIOSH recommended exposure limit (REL) for MWF aerosols (thoracic particulate mass).ConclusionsDespite MWF exposures below the NIOSH REL, exposed workers had a higher prevalence of asthma, WRA, and dermatitis symptoms than unexposed workers. Recommendations to reduce exposure included configuring mist collectors to automatically turn on when the machine is in use, and enforcing enclosure use. Am. J. Ind. Med. 56:1394–1401, 2013. © 2013 Wiley Periodicals, Inc.
Opioid poisonings and opioid adverse effects in workers in Washington State
Authors: Fulton‐Kehoe Deborah , Garg Renu K. , Turner Judith A. , Bauer Amy M. , Sullivan Mark D. , Wickizer Thomas M. , Franklin Gary M. 
Published: October 2013

AbstractObjectiveTo examine trends in opioid poisonings and adverse effects in Washington (WA) State and nationally.MethodsWe calculated rates of opioid poisonings and adverse effects and examined opioid prescriptions in the WA workers' compensation system, 2004–2010. Using Health Care Cost and Utilization Project (HCUP), Nationwide Inpatient Sample (NIS) data, we also calculated national rates of opioid poisonings and adverse effects, 1993–2010.ResultsWe identified 96 opioid poisonings and 312 opioid‐related adverse effects in WA, 2004–2010. The rates did not change substantially over these years. Most poisonings and adverse effects occurred in cases without chronic opioid use and with prescribed doses <120 mg/day morphine‐equivalent dose. Nationally, the rates of opioid poisonings and adverse effects increased significantly from 1993 to 2010.ConclusionsMany poisonings and adverse effects occurred in patients without high dose or long‐term opioid therapy, suggesting that opioid dosing and duration guidelines may not be sufficient to reduce morbidity related to prescription opioid use. Am. J. Ind. Med. 56:1452–1462, 2013. © 2013 Wiley Periodicals, Inc.
MED12 related disorders
Authors: Graham John M. , Schwartz Charles E. 
Published: October 2013

AbstractMED12is a member of the large Mediator complex, which has a critical and central role in RNA polymerase II transcription. As a multiprotien complex, Mediator regulates signals involved in cell growth, development, and differentiation, and it is involved in a protein network required for extraneuronal gene silencing and also functions as a direct suppressor of Gli3‐dependent Sonic hedgehog signaling. This may explain its role in several different X‐linked intellectual disability syndromes that share some overlapping clinical features. This review will compare and contrast four different clinical conditions that have been associated with different mutations in MED12, which is located at Xq13. To date, these conditions include Opitz–Kaveggia (FG) syndrome, Lujan syndrome, Ohdo syndrome (Maat–Kievit–Brunner type, or OSMKB), and one large family with profound X‐linked intellectual disability due to a novel c.5898insC frameshift mutation that unlike the other three syndromes, resulted in affected female carriers and truncation of the MED12 protein. It is likely that more MED12 mutations will be detected in sporadic patients and X‐linked families with intellectual disability and dysmorphic features as exome sequencing becomes more commonly utilized, and this overview of MED12‐related disorders may help to correlate MED12 genotypes with clinical findings. © 2013 Wiley Periodicals, Inc.
Elements of morphology: General terms for congenital anomalies
Authors: Hennekam Raoul C. , Biesecker Leslie G. , Allanson Judith E. , Hall Judith G. , Opitz John M. , Temple I Karen , Carey John C. ,   Elements of Morphology Consortium
Published: October 2013

AbstractAn international group of clinicians working in the field of dysmorphology has established a process for the standardization of terms used to describe human morphology. The goals are to standardize these terms and develop consensus regarding their definitions. This project will increase the usefulness and precision of descriptions of the human phenotype and facilitate reliable comparisons of phenotypic findings among clinicians and researchers in medicine, developmental biology, and genetics. Here we define and illustrate the general terms that describe congenital anomalies as related to human conditions. © 2013 Wiley Periodicals, Inc.
Biallelic SEMA3A defects cause a novel type of syndromic short stature
Authors: Hofmann Kristin , Zweier Markus , Sticht Heinrich , Zweier Christiane , Wittmann Wolfgang , Hoyer Juliane , Uebe Steffen , van Haeringen Arie , Thiel Christian T. , Ekici Arif B. , Reis André , Rauch Anita 
Published: October 2013

ABSTRACTChromosomal microarray testing is commonly used to identify disease causing de novo copy number variants in patients with developmental delay and multiple congenital anomalies. In such a patient we now observed an 150 kb deletion on chromosome 7q21.11 affecting the first exon of the axon guidance molecule gene SEMA3A (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A). This deletion was inherited from the healthy father, but considering the function of SEMA3A and phenotypic similarity to the knock‐out mice, we still assumed a pathogenic relevance and tested for a recessive second defect. Sequencing of SEMA3A in the patient indeed revealed the de novo in‐frame mutation p.Phe316_Lys317delinsThrSerSerAsnGlu. Cloning of the mutated allele in combination with two informative SNPs confirmed compound heterozygosity in the patient. While the altered protein structure was predicted to be benign, aberrant splicing resulting in a premature stop codon was proven by RT‐PCR to occur in about half of the transcripts from this allele. Expression profiling in human fetal and adult cDNA panels, confirmed a high expression of SEMA3A in all brain regions as well as in adult and fetal heart and fetal skeletal muscle. Normal intellectual development in the patient was surprising but may be explained by the remaining 20% of SEMA3A expression level demonstrated by quantitative RT‐PCR. We therefore report a novel autosomal recessive syndrome characterized by postnatal short stature with relative macrocephaly, camptodactyly, septal heart defect and several minor anomalies caused by biallelic mutations in SEMA3A. © 2013 Wiley Periodicals, Inc.
The growing complexity of the intestinal polyposis syndromes
Authors: Lucci‐Cordisco Emanuela , Risio Mauro , Venesio Tiziana , Genuardi Maurizio 
Published: October 2013

AbstractFamilial adenomatous polyposis has been the first form of inherited intestinal polyposis to be recognized. For a long time it has been considered the main polyposis syndrome, associated with an easily recognizable phenotype, with a marginal role attributed to a few very rare hamartomatous conditions. More recently, it has been gradually demonstrated that the intestinal polyposes encompass a range of conditions within a wide spectrum of disease severity, polyp histology, and extraintestinal manifestations. A growing number of genes and phenotypes has been identified, and heterogeneity of somatic molecular pathways underlying epithelial transformation in different syndromes and associated tumors has been documented. Increasing knowledge on the molecular bases and more widespread use of genetic tests has shown phenotypic overlaps between conditions that were previously considered distinct, highlighting diagnostic difficulties. With the advent of next generation sequencing, the diagnosis and the classification of these syndromes will be progressively based more on genetic testing results. However, the phenotypic variability documented among patients with mutations in the same genes cannot be fully explained by different expressivity, indicating a role for as yet unknown modifying factors. Until the latter will be identified, the management of patients with polyposis syndromes should be guided by both clinical and genetic findings. © 2013 Wiley Periodicals, Inc.
Science, art, and mistery in the statues and in the anatomical machines of the prince of sansevero: The masterpieces of the “Sansevero Chapel”
Authors: Della Monica Matteo , Galzerano Domenico , Di Michele Sara , Acquaviva Fabio , Gregorio Giovanni , Lonardo Fortunato , Sguazzo Francesca , Scarano Francesca , Lama Diana , Scarano Gioacchino 
Published: October 2013

ABSTRACTDuring the 18th century in Naples, Raimondo di Sangro, Prince of Sansevero, completed works on the family chapel, the so‐called “Cappella Sansevero.” The chapel houses statues of extraordinary beauty and spectacularly detailed but also, in the basement, two human skeletons known as the “Anatomical Machines” (“Macchine Anatomiche”). These two skeletons, a man and a pregnant woman, are entirely surrounded by their circulatory systems, just as if these were suddenly fixed. Legend, believed as truth until few years ago, says that Prince Raimondo had prepared and injected an unknown embalming substance in the blood vessels of two of his servants convicting them to eternal fixity. Recent investigations have demonstrated that, while the bones are authentic, the blood vessels are actually extraordinary artifacts that also reproduce some congenital malformations. The dreadful aspect of these two skeletons appears to be in strident contrast with the classic beauty of the statues which glorify and celebrate the ideal of morphology. Conversely, the two Anatomical Machines, protagonists of legends and superstitions since centuries, represent a marvelous example of science mixed with art. © 2013 Wiley Periodicals, Inc.