bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of peri-implant tissue clinical parameters in patients starting anti-osteoporosis medication after existing implant function: a prospective cohort study
Authors: Seki Keisuke , Tamagawa Takaaki , Yasuda Hiroyasu , Manaka Soichiro , Akita Daisuke , Kamimoto Atsushi , Hagiwara Yoshiyuki 
Published: July 2024

Abstract

Purpose
Rare cases of peri-implant medication-related osteonecrosis of the jaw (PI-MRONJ) have recently been reported. Cases that occur after the implant has been functional and the use of anti-osteoporosis medications (AOM) has begun are unpredictable and pose a significant threat to the patient. In this study, we aimed to evaluate the impact of AOM on peri-implant tissues and to examine risk factors for peri-implantitis, which is presumed to be a trigger for PI-MRONJ.
Methods
The study cohort consisted of patients who underwent implant maintenance treatment between January 2016 and February 2024. Patients were divided into AOM users (AOM group) and controls (control group). Clinical parameters of implant probing depth (iPPD), implant bleeding on probing (iBoP), marginal bone resorption (MBL), and mandibular cortical index (MCI) measured at baseline and at the last visit were statistically evaluated. Risk factors were examined by multivariate analysis for adjusted odds ratios.
Results
A total of 94 patients (35 male, 59 female) with 270 implants were recruited. The AOM group had 93 implants (24 patients). Comparison of clinical parameters showed that the AOM group had significantly greater changes in iBoP and MBL over time than the control group. Risk factors for peri-implantitis were a history of moderate or severe periodontal disease (OR: 15.8, 95% CI 3.6–69.3) and MCI class 3 (OR: 3.3, 95% CI 1.4–7.8).
Conclusions
In implant treatment of AOM users in an aging society, special attention should be paid to local inflammation, which is presumed to be the cause of PI-MRONJ.
Dexamethasone intravitreal implant for retinitis pigmentosa combined with macular edema：A case report
Authors: JIANG XIN-HONG , CHEN ZHI-PING , LIU RU-BING , LIU HONG-MING , ZHANG WEI-YI , WU XIAO-JIAN , ZOU YU-LING 
Published: July 2024

Abstract

RP is a highly blinding disease, with central vision often impaired when accompanied by macular oedema, for which there is no clear and effective treatment. Current treatment options include oral and topical carbonic anhydrase inhibitors, oral, topical, intravitreal, periocular injections of steroids, topical nonsteroidal anti-inflammatory drugs, retinal laser photocoagulation, vitrectomy and inner border membrane peeling, oral lutein, and intravitreal anti-vascular endothelial growth factor injections. We report a case of a patient who was given bilateral vitreous injections of dexamethasone intravitreal implant.We report the case of a 33-year-old male with night blindness since childhood, blurred vision in both eyes for more than 3 months, previously healthy, with peripheral retinal osteoclastic pigmentation, small retinal arteries, and thickening of retinal oedema in the macula.OCT showed cystic changes in the macula in both eyes, FFA exhibited an increased level of fluorescence leakage in both the left and right eyes. Petal-like fluorescence accumulation was seen in the macular area in the late stage, which led to the diagnosis of bilateral retinitis pigmentosa with macular oedema in both eyes. Best-corrected visual acuity improved and macular oedema were subsided after about two months of treatment, and Ozurdex might be useful in the treatment of retinitis pigmentosa with macular oedema.
The Long-term Consequences of Fertility on the Elderly’s Labor Supply
Authors: Wang Sophie Xuefei 
Published: July 2024

Abstract

Two trends are shaping the demographic structure in China in recent decades: population ageing and declining fertility. This paper explores the long-term effect of fertility on the elderly’s labor supply in China. By applying the instrumental variable methods on the China Health and Retirement Longitudinal Study (CHARLS) dataset, I find that having more children decreases the elderly’s labor supply, especially for the disadvantaged elderly, including females, those living in rural regions and those with low levels of educational attainment. The negative effect is concentrated on the effect on the extensive margin of labor supply, rather than the intensive margin. I rule out co-residence with adult children and providing care to grandchildren as potential channels for the negative effect on the elderly’s labor supply. The increase in the net transfer from children as the number of children increases can be a viable explanation for the negative effect. The linkage between fertility and labor supply of the elderly has important policy implications.
Assessing brain activity in patients with disorder of consciousness using the amplitude of low-frequency fluctuations and regional homogeneity derived from resting-state functional magnetic resonance images
Authors: Qin Xuewei , Chen Xuanling , Yao Lan , niu hongchuan , Wang Shengpei , He Jianghong , Guo Xiangyang , Li Xiaoli 
Published: July 2024

Abstract

Objective
Disorder of consciousness (DoC) is an impaired state of consciousness. This study used the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) measures obtained from resting-state functional magnetic resonance imaging (rs-fMRI) to observe neuronal activity changes in patients with DoC from various injuries for prognostic predictions.
Methods
This study included six patients with traumatic brain injury (TBI)-induced DoC and six patients with cerebrovascular disease (CVD)-induced DoC. Images were processed using Data Processing Assistant for rs-fMRI software to obtain the ALFF and ReHo values.
Results
The ALFF values were lower in the TBI group than in the CVD (i.e., control) group for the Precuneus_R, Superior frontal gyrus_R, Middle frontal gyrus, Middle occipital gyrus, and Hippocampus_R but higher for the bilateral insula, Postcentral gyrus_L, right moment gyrus, Superior parietal gyrus_L, and Inferior temporal gyrus_L. The ReHo values were higher in the TBI group than in the CVD group for the Precental gyrus_L and Postcentral gyrus_L, Middle temporal gyrus_R, right superior temporal gyrus, Superior temporal gyrus_R, Superior parietal gyrus_L, Superior frontal gyrus_R, and Inferior frontal gyrus)_L but lower for the Insula_R, Postcentral gyrus_R, Inferior frontal gyrus, Orbital part_L, straight gyrus, and Anterior cingulate_L. Consciousness improved in three patients with CVD DoC and one with TBI DoC.
Conclusion
ALFF and ReHo enhancements in the precuneus and frontal lobes on rs-fMRI might suggest improved consciousness for patients with CVD and TBI DoC.
Comparative Analysis of the Risk of Severe Bacterial Infection and Septicemia in Adolescents and Young Adults with Treatment-Resistant Depression and Treatment- Responsive Depression - A Nationwide Cohort Study in Taiwan
Authors: Li Jia-Ru , Kao Yu-Chen , Tsai Shih-Jen , Bai Ya-Mei , Su Tung-Ping , Chen Tzeng-Ji , Liang Chih-Sung , Chen Mu-Hong 
Published: July 2024

Abstract

Background
Previous studies have shown an association between depression and susceptibility to infection in adults. However, few studies have investigated the association between treatment-resistant depression (TRD) and severe infections in adolescents and young adults.
Methods
This study included adolescents (12–19 years of age) and young adults (20–29 years of age) who were diagnosed with major depressive disorder (MDD, including 6958 cases of TRD and 27832 cases of antidepressant-responsive depression [ARPD]), from the Taiwan National Health Insurance Research Database (NHIRD), from 2001 to 2010. The TRD and ARPD groups were further matched (4:1) by chronological age, age at diagnosis of depression, sex, residence, and family income. The primary outcomes were severe bacterial infections (SBI) and septicemia. Cox regression analysis was conducted to identify the risk of hospitalization due to SBI or septicemia during the follow-up period.
Results
Compared with controls, the ARPD group had increased risks of SBI (hazard ratio [HR] with 95% confidence interval [CI]: 3.90, 2.73–5.57) and septicemia (HR, 95% CI: 2.56, 1.34–4.91). Notably, the risks of SBI and septicemia appeared to be further elevated in the TRD group. The TRD group exhibited higher incidences of SBI (HR, 95% CI: 6.99, 4.73–10.34) and septicemia (HR, 95% CI: 2.85, 1.28–6.36) than the control group.
Conclusions
Adolescents and young adults with TRD had 6.99-fold and 3.90-fold increased risks of SBI and septicemia compared to individuals without MDD, respectively. Therefore, healthcare providers need to be vigilant when monitoring and implementing preventive measures in this population.
Potentially Inappropriate Medication Use, Comorbidity and Quality of Life in Community-Dwelling Older People: A Cross-Sectional Study in Iran
Authors: Shirdozham Maryam , Rahimi Majid , feizi Awat 
Published: July 2024

Abstract

Background
Multimorbidity, polypharmacy and potentially inappropriate medication use in elderly people are prevalent which affect the quality of life in them. This study investigates the interrelationship between potentially inappropriate medication use, polypharmacy, comorbidity, and the quality of life among elderly people in Iran.
Methods
This cross-sectional study was conducted on 500 elderly people in Isfahan City, Iran. the Beers criteria for Potentially Inappropriate Medication Use in Older Adults, a health-related quality-of-life questionnaire for elderly people, and the Charlson comorbidity index were used for gathering data.
Results
Our findings related to the elderly living in Isfahan community Dewelling showed that the prevalence of PIM = 61.6% and the most common drug category was related to painkillers, the average quality of life score was (0.86 ± 0.08) and the worst category was related to the sleep status of the elderly Was. The average score of CCI = 3.63 ± 1.40 and the most frequent diseases of the elderly were blood lipids, hypertension and diabetes.After adjusting for intervening variables, there was a negative relationship between CCI(B=-0.009(SE = 0.0027), P < 0.001) and PIM(B =- 0.03(SE = 0.007); P < 0.001) was observed with quality of life
Conclusion
Potentially inappropriate medication use and comorbidities in our older population are high and these variables are negatively associated with quality of life in this population. There are few educated family physicians in geriatrics in Iran. Policymakers should pay attention to these issues.
VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model
Authors: Guo Song , Rasmussen Rikke Holm , Hay-Schmidt Anders , Ashina Messoud , Asuni Ayodeji A. , Hansen Jeppe Møller , Holm Anja , Lauritzen Sabrina Prehn , Dorsam Glenn , Hannibal Jens , Georg Birgitte , Kristensen David Møbjerg , Olesen Jes , Christensen Sarah Louise 
Published: July 2024

Abstract

Background
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target. Although intravenous PACAP triggers migraine attacks and a recent phase II trial with a PACAP-inhibiting antibody showed efficacy in migraine prevention, targeting the PACAP receptor PAC1 alone has been unsuccessful. The present study investigated the role of three PACAP receptors (PAC1, VPAC1 and VPAC2) in inducing migraine-relevant hypersensitivity in mice.
Methods
Migraine-relevant hindpaw hypersensitivity was induced by repeated PACAP38 injections. Tactile sensitivity responses were quantified using von Frey filaments in three knockout (KO) mouse strains, each lacking one of the PACAP-receptors (Ntotal = 160). Additionally, ex vivo wire myography was used to assess vasoactivity of the carotid artery, and gene expression of PACAP receptors was examined by qPCR.
Results
PACAP38 induced hypersensitivity in WT controls (p < 0.01) that was diminished in VPAC1 and VPAC2 KO mice (p < 0.05). In contrast, PAC1 KO mice showed similar responses to WT controls (p > 0.05). Myograph experiments supported these findings showing diminished vasoactivity in VPAC1 and VPAC2 KO mice. We found no upregulation of the non-modified PACAP receptors in KO mice.
Conclusions
This study assessed all three PACAP receptors in a migraine mouse model and suggests a significant role of VPAC receptors in migraine pathophysiology. The lack of hypersensitivity reduction in PAC1 KO mice hint at the involvement of other PACAP receptors or compensatory mechanisms. The results indicate that targeting only individual PACAP receptors may not be an effective migraine treatment.
Physical, but not laboratory, treatment-related adverse events are associated with favorable outcomes of enfortumab vedotin for advanced urothelial carcinoma: A landmark analysis
Authors: Taguchi Satoru , Kawai Taketo , Ambe Yoshiki , Kishitani Kenjiro , Noda Michio , Kaneko Tomoyuki , Miyakawa Jimpei , Nakamura Yu , Hoshina Hayato , Obinata Daisuke , Yamaguchi Kenya , Kakutani Shigenori , Furuya Yoshitsune , Sato Yujiro , Adachi Yume , Sugimoto Kazuma , Sato Keigo , Tabata Mariko , Tanaka Takehiro , Nara Katsuhiko , Uemura Yukari , Kamei Jun , Akiyama Yoshiyuki , Sato Yusuke , Yamada Yuta , Niimi Aya , Yamada Daisuke , Takada Tappei , Takahashi Sayuri , Yamada Yukio , Miyazaki Hideyo , Enomoto Yutaka , Nishimatsu Hiroaki , Fujimura Tetsuya , Fukuhara Hiroshi , Nakagawa Tohru , Takahashi Satoru , Kume Haruki 
Published: July 2024

Abstract

Background
While the occurrence of immune-related adverse events has been recognized as a prognostic marker in patients receiving immune checkpoint inhibitors, the prognostic significance of treatment-related adverse events (trAEs) in patients undergoing antibody–drug conjugates such as enfortumab vedotin (EV) is controversial.
Methods
We reviewed 106 patients with advanced urothelial carcinoma who were treated with EV therapy at 10 institutions between 2021 and 2023. Associations of clinical parameters with overall survival and progression-free survival were assessed using the Cox proportional hazards model. For the assessment of trAEs, landmark analysis was conducted to minimize immortal time bias.
Results
Of 106 patients, 55 (51.9%) experienced disease progression and 44 (41.5%) died during the follow-up period. Any grade and grade ≥ 3 trAEs occurred in 94 (88.7%) and 44 (41.5%) patients, respectively. Common trAEs included skin disorders (74.5%), gastrointestinal disorders (62.3%), fatigue (50.0%), peripheral neuropathy (36.8%), and hematological disorders (37.7%). One patient died of interstitial pneumonia (grade 5). According to landmark analysis using 88 patients who survived for two months or more, trAEs were significantly associated with longer survival. Furthermore, when trAEs were classified into “physical trAEs” such as skin disorders and “laboratory trAEs” such as hematological disorders, the former were associated with longer survival while the latter were associated with shorter survival.
Conclusions
Physical, but not laboratory, trAEs are associated with favorable outcomes of EV therapy for advanced urothelial carcinoma. Both managing trAEs and utilizing them as prognostic markers are key points in the use of antibody–drug conjugates such as EV.
A Dual-Correlation Feature Enhancement Network Model Based on Transformer for Occluded Pedestrian Re-identification
Authors: Zhao Zoufei , Li Lihong , Liu Qingqing , Zeng Ziwei , Teng Peixian 
Published: July 2024

Abstract

In pedestrian re-identification, retrieving occluded pedestrians remains a challenging problem. The current methods primarily utilize additional networks to provide body cues for distinguishing the visible parts of the body. However, the inevitable domain gap between the auxiliary models and the Re-ID datasets significantly increases the difficulty in obtaining effective and efficient models. To eliminate the need for additional pre-trained networks, a Transformer-based dual correlation feature enhancement network model is proposed. Specifically, this method designs a relation-based feature enhancement module that effectively compensates for the absence or inaccuracy of local features by modeling the relational information within pedestrian images. Additionally, a dual correlation fusion module is designed to adaptively generate feature weights, fusing global and local features with weighted summation. Finally, extensive experiments were conducted on both occluded and holistic datasets to demonstrate that the proposed model outperforms state-of-the-art methods. The proposed model achieved a Rank-1 accuracy of 72.2% on the Occluded-Duke dataset and 88.0% on the Partial-REID dataset. This proves the effectiveness of the proposed approach.
Vertical Bearing Behavior and Pile Group Effect for Cemented-Soil Composite Pile Groups Based on On-Site Experiments
Authors: Gong Zhiyu , Dai Guoliang , Chen Xinsheng , Ouyang Haoran , Hu Tao , Chen Zhiwei 
Published: July 2024

Abstract

Bearing characteristics and interactions of a pile group are complex. and there is almost no on-site full-scale test data for cemented-soil composite pile group. In this research, vertical static load tests were conducted on two isolated pile, two-pile group and six-pile group for long-core SDCM pile. The bearing behavior of long-core SDCM pile and the interaction between pile groups have been studied. The results indicate that the long-core SDCM single pile is a typical friction type pile, and cemented soil provides most of the lateral friction resistance for the bearing capacity. In pile groups, pile spacing is the main factor affecting the pile group effect. The model calculation results based on the equivalent pier method are verified using on-site test data and the key parameters in the pile group for long-core SDCM pile including pile spacing Sij, cemented soil Elastic modulus Ec and PHC pipe pile Elastic modulus Ep are analyzed using a mathematical model. Parameter analysis results indicate that the pile group interaction for long-core SDCM pile is mainly reflected in settlement. Group effect is inapparent at pile spacing greater than 4 D. The appropriate value of Ec and Ep are taken in the range of 0.8-1.0 GPa and 30-40 GPa.
Role of Immune Cells in Mediating the Effect of Gut Microbiota on Renal Cell Carcinoma
Authors: Wang Chen , Chen Xin 
Published: July 2024

Abstract

Background
The gut microbiota plays a crucial role in the development of various illnesses, including immune-related disorders. However, the potential association between renal cell carcinoma (RCC) and gut microbiota remains underexplored.
Methods
We utilized data from Genome-Wide Association Studies (GWAS) public databases to perform a bidirectional Mendelian randomization (MR) analysis with two samples, aiming to investigate the causal relationship between gut microbiota and RCC. The primary analysis employed the inverse variance weighted (IVW) method. Extensive sensitivity analyses were conducted to evaluate heterogeneity and horizontal pleiotropy. Additionally, a two-step MR was used to identify potential mediator.
Results
Our analysis identified significant associations between 22 microbiota taxa and RCC, along with several immune cell traits implicated in RCC modulation by gut microbiota. For instance, Demequinaceae affected RCC through CD14- CD16- AC and CD45 on HLA DR + NK cells. Mediation effect proportions were used to explore the intricate relationships among gut microbiota exposures, immune markers, and their impact on RCC.
Conclusion
This study reveals the complex interplay between the gut microbiome, immune cells, and RCC. The associations and mediated effects of gut microbiota management for RCC offer valuable insights for future therapeutic strategies.
Optimizing Crowd Evacuation: Evaluation of Strategies for Safety and Efficiency
Authors: Oliveira Hugo S. 
Published: July 2024

Abstract

Predicting and controlling crowd dynamics in emergencies is one of the main objectives of simulated emergency exercises. However, during emergency exercises, there is often a lack of sense of danger by the actors involved and concerns about exposing real people to potentially dangerous environments.
These problems impose limitations in running an emergency drill, harming the collection of valuable information for posterior analysis and decision-making. This work aims to mitigate these problems by using \gls{abm} simulator to deepen the comprehension of human actions when exposed to a sudden variation in extensive crowded environmental conditions and how evacuation strategies affect evacuation performance. To assess the impact of the evacuation strategy, we propose a modified informed leader-flowing approach and compare it with common evacuation strategies in a simulated environment to replicate typical stadium benches with narrow corridors leading to different exit points. The emergency is triggered when one or more fire erupts on the bench, leading to a sudden behaviour change, with people trying to find their way out quickly. The objective is to determine the impact of each set of configurations and evacuation strategies. Our experiments determined that agents following the leader with vital real-time information achieved lower fatality counts and exit times in all evaluation scenarios, proving that relevant and controlled information is crucial in an emergency evacuation scenario.
Evaluation of the Synergistic Effect of Thymol/Ampicillin on Escherichia coli strains
Authors: jafari sajjad , Shirmohammadpour Mina , jafari sajjad sajjad , Mirzaei Bahman 
Published: July 2024

Abstract

Introduction:
The purpose of this study was to investigate the synergistic effect of thymol/ampicillin on Escherichia coli (E. coli).
Material and methods
Antimicrobial effect of thymol, and ampicillin individually and in combination with different concentrations on E. coli ATCC25922 were performed by MIC-MBC method. The antimicrobial effect of a compound that had synergistic effect on twenty clinical strains of E. coli bacteria was performed by the MIC-MBC method, and the identification of chemical bonds, functional groups, and molecular interactions of this compound was investigated with an FTIR device. Checkered method, time-killing curve and biofilm inhibition on E. coli ATCC25922 bacteria, and investigation of cytotoxicity on human red blood cells (RBCs) by hemolysis method and human skin fibroblast cells (Ffk) with MTT method were performed. F1 compound had a synergistic effect.
Results
The results of this study showed that the antimicrobial effects of thymol, ampicillin, and thymol/ampicillin (F1 compound), on E. coli ATCC25922 were 256, 8, 8/2 µg/ml (FICI: 1) respectively. The antimicrobial effects of the F1 compound on clinical strains of E. coli were 128–512/32–64 µg/ml respectively. The time curve for killing E. coli was higher in the combined mode than in the individual modes. These compounds had chemical bonds OH carbohydrates proteins, polyphenols, C = O Amide I band, C-O-Cpolysaccharide, and C-Namide III band, but C = C conjugated, C ≡ C compound, shows the connection between thymol/ampicillin. The biofilm inhibition rate of thymol, ampicillin, and thymol/ampicillin against E. coli bacteria was 29.69%, 60%, and 62% respectively. The toxicity of thymol, ampicillin, and F1 compound against human RBCs were 36.12, 8.38, and 9.54, and against human Ffk cells were 9.92, 6.83, and 9.33 respectively.
Discussion
Considering the resistance of ampicillin in the treatment of diseases caused by E. coli, the results of this study proved that the thymol/ampicillin has high anti-bacterial and anti-biofilm properties. Toxicity on several cells was the same, and this compound can be tested later.