bluuebunny/crossref_metadata_2025_split huggingface dataset:
L'équivoque interprétative
Authors: Sous Jean-Louis 
Published: April 2013

La figure de l’équivoque n’a cessé d’accompagner Lacan tout au long de son frayage et notamment en matière d’interprétation. Mais qu’est-ce qu’une équivoque ? Quels sont sa portée et son effet ? Dans quel registre opèret-elle ? Pour le moins, ce n’est pas une notion univoque ! Il s’agira ici de proposer deux cas de figure que l’on pourrait nommer : équivoque-parasite et équivoque-résonance .
Make it E.U. friendly
Authors: Laurens Sylvain 
Published: April 2013

Resume	Les discours médiatiques ou militants sur le lobbying à Bruxelles mettent souvent en avant la « figure » du conseiller influent. Mais défendre des « intérêts » industriels ou économiques auprès des responsables institutionnels européens suppose au préalable que les contradictions propres aux activités économiques aient été levées. À partir d'une série de données fiscales et l'observation ethnographique de réunions internes de business associations européennes, cet article se propose d'entrer dans la « boîte » noire des organisations patronales. Il rend compte des stratégies différenciées que les eurogroupes mobilisent pour que les intérêts des grandes entreprises soient ordonnés, « mis en ordre de marche » par une série d'acteurs dont la tâche est justement d'homogénéiser les points de vue et de les rendre audibles au sein de l'espace politique et institutionnel bruxellois.
L'entrepreneuriat au service des politiques sociales : La fabrication du consensus politique sur le dispositif de l'auto-entrepreneur
Authors: Abdelnour Sarah 
Published: April 2013

Résumé Le régime de l’auto-entrepreneur, mis en place en 2009, marque un infléchissement des politiques d’encouragement à la création d’entreprise d’une logique d’emploi à celle de cumul des revenus. Cet article vise à saisir les conditions structurelles et discursives qui ont permis l’élaboration de ce régime au sein de l’État au croisement de plusieurs logiques libérales. Il se base sur des sources officielles ainsi que sur une trentaine d’entretiens réalisés avec les acteurs, soutiens et opposants, du dispositif. Il s’intéresse aux convergences d’intérêt qui ont permis l’intégration d’un projet du « tous entrepreneurs » initié par un secrétaire d’État libéral dans la loi programmatique de l’économie de la nouvelle administration politique française. En faisant de l’entrepreneur la nouvelle figure de l’héroïsme populaire en temps de crise, et ainsi en transférant le référentiel entrepreneurial dans le domaine des politiques sociales, Hervé Novelli et ses collaborateurs ont pu obtenir des soutiens politiques stratégiques, et ainsi surmonter certaines résistances venues des administrations oeuvrant pour la rigueur budgétaire, en proposant un projet qui déconstruit un modèle social fondé sur le statut salarial et l’État social.
Cancer Immunotherapies Ignited by a Thorough Machine Learning‐Based Selection of Neoantigens
Authors: Jurczak Sebastian , Druchok Maksym 
Published: July 2024

AbstractIdentification of neoantigens, derived from somatic DNA alterations, emerges as a promising strategy for cancer immunotherapies. However, not all somatic mutations result in immunogenicity, hence, efficient tools to predict the immunogenicity of neoepitopes are needed. A pipeline is presented that provides a comprehensive solution for the identification of neoepitopes based on genomic sequencing data. The pipeline consists of a data pre‐processing step and three machine learning predictive steps. The pre‐processing step analyzes genomic data for different types of alterations, produces a list of all possible antigens, and determines the human leukocyte antigen (HLA) type and T‐cell receptor (TCR) repertoire. The first predictive step performs a classification into antigens and neoantigens, selecting neoantigens for further consideration. The next step predicts the strength of binding between neoantigens and available major histocompatibility complexes of class I (MHC‐I). The third step is engaged to predict the likelihood of inducing an immune response. Neoepitopes satisfying all three predictive stages are assumed to be potent candidates to ensure immunogenicity. The predictive pipeline is used in two regimes: selecting neoantigens from patients' sequencing data and generating novel neoantigen candidates. Two different techniques — Monte Carlo and Reinforcement Learning – are implemented to facilitate the generative regime.
Breast Tumor Cell Survival and Morphology in a Brain‐like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties
Authors: Türker Esra , Andrade Mier Mateo S. , Faber Jessica , Padilla Padilla Selma J. , Murenu Nicoletta , Stahlhut Philipp , Lang Gregor , Lamberger Zan , Weigelt Jeanette , Schaefer Natascha , Tessmar Jörg , Strissel Pamela L. , Blunk Torsten , Budday Silvia , Strick Reiner , Villmann Carmen 
Published: July 2024

AbstractTriple‐negative breast cancer (TNBC) is the most invasive type of breast cancer with high risk of brain metastasis. To better understand interactions between breast tumors with the brain extracellular matrix (ECM), a 3D cell culture model is implemented using a thiolated hyaluronic acid (HA‐SH) based hydrogel. The latter is used as HA represents a major component of brain ECM. Melt‐electrowritten (MEW) scaffolds of box‐ and triangular‐shaped polycaprolactone (PCL) micro‐fibers for hydrogel reinforcement are utilized. Two different molecular weight HA‐SH materials (230 and 420 kDa) are used with elastic moduli of 148 ± 34 Pa (soft) and 1274 ± 440 Pa (stiff). Both hydrogels demonstrate similar porosities. The different molecular weight of HA‐SH, however, significantly changes mechanical properties, e.g., stiffness, nonlinearity, and hysteresis. The breast tumor cell line MDA‐MB‐231 forms mainly multicellular aggregates in both HA‐SH hydrogels but sustains high viability (75%). Supplementation of HA‐SH hydrogels with ECM components does not affect gene expression but improves cell viability and impacts cellular distribution and morphology. The presence of other brain cell types further support numerous cell–cell interactions with tumor cells. In summary, the present 3D cell culture model represents a novel tool establishing a disease cell culture model in a systematic way.
Silicon Optrode with a Micromirror‐Tip Providing Tunable Beam Profile During Infrared Neuromodulation of the Rat Neocortex
Authors: Horváth Ágoston Csaba , Mórocz Ákos , Csomai Borbála , Szabó Ágnes , Balogh‐Lantos Zsófia , Fürjes Péter , Tóth Estilla Zsófia , Fiáth Richárd , Fekete Zoltán 
Published: July 2024

AbstractInfrared (IR) neuromodulation holds an increasing potential in brain research, which is fueled by novel neuroengineering approaches facilitating the exploration of the biophysical mechanism in the microscale. The group lays down the fundamentals of spatially controlled optical manipulation of inherently temperature‐sensitive neuronal populations. The concept and in vivo validation of a multifunctional, optical stimulation microdevice is presented, which expands the capabilities of conventional optrodes by coupling IR light through a monolithically integrated parabolic micromirror. Heat distribution in the irradiated volume is experimentally analyzed, and the performance of the integrated electrophysiological recording components of the device is tested in the neocortex of anesthetized rodents. Evoked single‐cell responses upon IR irradiation through the novel microtool are evaluated in multiple trials. The safe operation of the implanted device is also presented using immunohistological methods. The results confirm that shift in temperature distribution in the vicinity of the optrode tip can be controlled by the integrated photonic components, and in parallel with the optical stimulation, the device is suitable to interrogate the evoked electrophysiological activity at the single neuron level. The customizable and scalable optrode system provides a new pathway to tailor the location of the heat maximum during infrared neural stimulation.
Why academics under‐share research data: A social relational theory
Authors: Mattern Janice Bially , Kohlburn Joseph , Moulaison‐Sandy Heather 
Published: July 2024

AbstractDespite their professed enthusiasm for open science, faculty researchers have been documented as not freely sharing their data; instead, if sharing data at all, they take a minimal approach. A robust research agenda in LIS has documented the data under‐sharing practices in which they engage, and the motivations they profess. Using theoretical frameworks from sociology to complement research in LIS, this article examines the broader context in which researchers are situated, theorizing the social relational dynamics in academia that influence faculty decisions and practices relating to data sharing. We advance a theory that suggests that the academy has entered a period of transition, and faculty resistance to data sharing through foot‐dragging is one response to shifting power dynamics. If the theory is borne out empirically, proponents of open access will need to find a way to encourage open academic research practices without undermining the social value of academic researchers.
Cowpea mosaic virus intratumoral immunotherapy maintains stability and efficacy after long‐term storage
Authors: Simms Andrea , Zhao Zhongchao , Cedrone Edward , Dobrovolskaia Marina A. , Steinmetz Nicole F. 
Published: July 2024

AbstractCowpea mosaic virus (CPMV) has demonstrated superior immune stimulation and efficacy as an intratumoral immunotherapy, providing a strong argument for its clinical translation. One important consideration for any new drug candidate is the long‐term stability of the drug and its formulation. Therefore, our lab has evaluated the physical stability and biological activity, that is, anti‐tumor potency, of formulations of CPMV in buffer (with and without a sucrose preservative) in multiple temperature conditions ranging from ultralow freezers to a heated incubator over a period of 9 months. We found that non‐refrigerated temperatures 37°C and room temperature quickly led to CPMV destabilization, as evidenced by significant protein and RNA degradation after just 1 week. Refrigerated storage at 4°C extended physical stability, though signs of particle breakage and RNA escape appeared after 6 and 9 months. CPMV stored in frozen conditions, including −20°C, −80°C, and liquid N2, remained intact and matched the characteristics of fresh CPMV throughout the duration of the study. The biological activity was evaluated using a murine dermal melanoma model, and efficacy followed the observed trends in physical stability: CPMV stored in refrigerated and warmer conditions exhibited decreased anti‐tumor efficacy compared to freshly prepared formulations. Meanwhile, frozen‐stored CPMV performed similarly to freshly purified CPMV, resulting in reduced tumor growth and extended survival. Data, therefore, indicates that CPMV stored long‐term in cold or frozen conditions remains stable and efficacious, providing additional support to advance this powerful plant virus to translation.
Paravalvular leak closure of a native aortic valve for cardiogenic shock post valvular surgery
Authors: Lochy Stijn , Galloo Xavier , Droogmans Steven , Eeckhout Eric 
Published: July 2024

AbstractWe describe the case of a 55‐year‐old patient with cardiogenic shock postsurgical mitral valve replacement, because of a native aortic valve paravalvular leak due to surgical trauma. The patient was successfully treated with a muscular ventricular septum defect device. To the best of our knowledge, this is the first report describing percutaneous device treatment of a native aortic valve paravalvular leak.
Percutaneous pulmonary aspiration thrombectomy in an adolescent fontan patient using a large‐bore system
Authors: Selleslag Sébastien , Bonne Lawrence , Rex Steffen , Cools Björn 
Published: July 2024

AbstractWe describe the safe and effective percutaneous pulmonary thrombectomy in an 18‐year‐old female with a Fontan circulation using the FlowTriever® device (Inari Medical®, Irvine, US). Aspiration thrombectomy of both pulmonary arteries was performed using 24 and 16 F FlowTriever® catheters retrieving large amounts of thrombus material resulting in near total angiographic recanalization.
Dynamic Control Analysis of Various Side‐Stream Quaternary Extractive Distillation Configurations
Authors: Li Min , Peng Jiarui , Zhu Xiuyu , Zhang Zhishan , Ma Yixin , Gao Jun 
Published: July 2024

AbstractA thermally coupled distillation technology can bring energy‐saving benefits, but it poses challenges to process control. This article explores dynamic control of different side‐stream quaternary extractive distillation configurations. One the one hand, the open‐loop controllability of these processes is analyzed in terms of various criteria by the control design interface technology of Aspen Plus Dynamics. On the other hand, their control structures are established and examined by introducing large feed flow and composition perturbations. The results show that the triple‐side‐stream distillation still performs the best state and input–output controllability in spite of the strongest nonlinearity, and is also well resistant to large feed perturbations using a simple control structure.
Removal of Chromium from Aqueous Solution Using Ziziphus jujuba Seed‐Activated Biochar
Authors: Manthira Giri Prathap , Parathasarathy Purushothaman 
Published: July 2024

AbstractThe present study aims to remove chromium (Cr) from a synthetic solution using Ziziphus jujube seed (ZJS)‐activated biochar (ZJSAB) as an adsorbent. Physicochemical characterization was carried out to understand the properties of ZJSAB samples. Adsorption characteristics of ZJSAB were determined using batch experiments for various temperatures, pH, dosage, concentration, and duration. The study reveals ZJSAB has 93 % efficiency in the removal of Cr for an initial concentration of 60 mg L−1 at 30 °C and 2 pH with 0.6 g L−1 dosage and 120 min duration. Freundlich isotherm and pseudo‐second‐order models were best fit with maximum removal efficiency for ZJSAB. When 0.3 N hydrochloric acid was introduced to a desorption study, Cr desorption was 93.47 %. The study reveals that activated biochar from ZJS was efficient for Cr removal from aqueous solutions.
Effect of Precursor Concentrations on ZnO/Graphene/Nickel Foam for Photoelectrochemical Activity
Authors: Rosman Nurul Nabila , Shah Nur Rabiatul Adawiyah Mohd , Arifin Khuzaimah , Minggu Lorna Jeffery , Ludin Norasikin Ahmad , Yunus Rozan Mohamad 
Published: July 2024

AbstractZnO nanorods (NRs) were synthesized hydrothermally on a pre‐seeded graphene/nickel foam (NF) substrate. The effects of concentration on the photoelectrochemical (PEC) cell performance and hydrothermal reaction were studied. The field emission scanning electron microscopy images revealed that the precursor concentrations influenced the shape of the ZnO NRs on graphene/NF (ZGN). The X‐ray diffraction pattern for hexagonal wurtzite demonstrated strong orientation along the (002) direction. Notably, compared with the other concentrations, 0.04 M ZGN exhibited the highest photocurrent density, which was attributed to the optimal diameter and length of the rods for efficient light absorption. This research showed enhanced PEC performance, compared with existing literature, emphasizing the exceptional quality of the produced ZGN.
Study on Cracking/Oxidation/Integrated Reforming Reaction for Efficient Conversion of Biomass to High‐Quality Syngas
Authors: Chen Wenqing , He Tao , Gu Suning , Wu Jingli , Wang Zhiqi , Wu Jinhu 
Published: July 2024

AbstractThe advanced gasification technology of coal is mainly based on oxidation reaction and high temperature but is not suitable for biomass conversion. High tar and CO2 content are the two main issues that affect the efficiency of biomass gasification. In order to deeply convert hydrocarbons/tar and CO2 simultaneously, and enhance syngas yield, the cracking/partial oxidation/reforming reactions and their integrated reaction routes are investigated from an interrelated view. The effects of each reaction on the distribution of C/H elements in hydrocarbons/tar and syngas are illustrated. By cracking and oxidation reaction, the syngas yield can only reach 0.93 Nm3 kg−1, about 58 % of the theoretical maximum value; a large proportion of residual C/H atoms existing in stable hydrocarbons/tar/CO2/H2O are not converted. Based on the concept of lattice O oxidation combined with dry reforming, it realizes syngas yield (CO+H2) 1.56 Nm3 kg−1 with 91.6 % concentration, demonstrating that tar/hydrocarbons and CO2/H2O are converted to syngas efficiently. The effects of [O]/C ratio on gas yield represent a synergistic coordination between lattice Os oxidation and catalytic reforming reaction. Oxidation‐reforming is the optimum route for biomass conversion to high‐quality syngas.
Saccade and pupil changes in children recovering from opsoclonus‐myoclonus ataxia syndrome reveal midbrain alterations in oculomotor circuits
Authors: Munoz Douglas P. , White Brian J. , Brien Donald C. , Parbhoo Kajaal , Yea Carmen , Ann Yeh E. 
Published: July 2024

AbstractObjectiveThis study measured eye movements in children with a history of opsoclonus‐myoclonus ataxia syndrome in order to identify abnormalities in saccade and pupil behavior that map onto specific alterations in brainstem pathways.MethodsWe used video‐based eye tracking while participants freely viewed 10 min of short (2–4 s) video clips without instructions. Clip transitions represented a large visual perturbation and we quantified multiple characteristics of saccade and pupil responses following these transitions in 13 children recovering from opsoclonus‐myoclonus and 13 healthy, age‐matched control participants.ResultsThe frequency of saccades and distribution of fixation durations differed between the groups. Following the clip transitions, children recovering from opsoclonus‐myoclonus ataxia syndrome exhibited longer time to initiate saccades, leading to a delay in harvesting visual information. Clip transitions to lighter clips produced similar pupil constriction responses in the two groups. However, clip transitions to darker clips produced dilation responses that were initiated earlier and of greater magnitude in opsoclonus‐myoclonus ataxia syndrome, suggesting removal or suppression of a signal that delays dilation.InterpretationChildren with a history of opsoclonus‐myoclonus ataxia syndrome demonstrated key abnormalities in saccade and pupil metrics. We propose a novel hypothesis in which dysfunction in the pathway from the superior colliculus to the mesencephalic and pontine reticular formation that houses the saccade and pupil premotor circuits could produce these results.
Targeting autophagy: A promising approach for the treatment of breast cancer brain metastases
Authors: Nawrocki Steffan T. , Espitia Claudia M. , Espinoza Maria Janina Carrera , Gamble Madison E. , Sureshkumar Sruthi , Chang Mengyang , Wang Wei , Carew Jennifer S. 
Published: July 2024

AbstractPatients with breast tumours that metastasise to the brain have limited treatment options and a very poor prognosis. More effective therapeutic strategies are desperately needed for this patient population. Recent evidence demonstrates that brain metastases arising from breast tumours display altered energy production that results in enhanced autophagy. Preclinical studies have shown that genetically or pharmacologically disrupting the autophagy pathway significantly decreases the brain metastatic burden, resulting in improved animal survival and increased sensitivity to lapatinib. These findings pave the way for the development of novel strategies targeting autophagy for breast cancer patients with brain metastatic disease.
Gastrointestinal endoscopy training in the United States: Program structure and competence assessment
Authors: Tomizawa Yutaka 
Published: July 2024

AbstractThe general principles of gastrointestinal endoscopy training in the United States were formulated and summarized more than a decade ago and the principles have been consistent until now. To summarize, trainees should be prepared to (i) appropriately recommend endoscopic procedures as indicated by the findings of the consultative evaluation, with an explicit understanding of accepted specific indications, contraindications, and diagnostic/therapeutic alternatives, (ii) perform procedures safely, completely, and expeditiously, including possessing a thorough understanding of the principles of conscious sedation/analgesia techniques, the use of anesthesia‐assisted sedation where appropriate, and pre‐procedure clinical assessment and patient monitoring, (iii) correctly interpret endoscopic findings and integrate them into medical or endoscopic therapy, (iv) identify risk factors for each procedure, understand how to minimize each, and recognize and appropriately manage complications when they occur, (v) acknowledge the limitations of endoscopic procedures and personal skills and know when to request help, and (vi) understand the principles of quality measurement and improvement. This article provides an overview of the endoscopy training system and structure, evaluation scheme, and competence and credentialing process in the United States.
Multi‐objective assessment of the water‐energy‐environment‐food nexus involving a life cycle assessment approach
Authors: Rodríguez‐Gutiérrez Jesús Eduardo , Ríos‐Fuentes Brenda , Altamirano‐Corona José Luis , Estrada‐Baltazar Alejandro , Fuentes‐Cortés Luis Fabián 
Published: July 2024

AbstractThis work addresses the multi‐objective design of water, energy and food supply systems in isolated rural communities using local resources. The approach used considers objective functions based on life cycle analysis such as water and carbon footprint, as well as economic performance considering the application and integration of normalized metrics to address the water‐energy‐environment‐food nexus. The results show that it is possible to build robust and accessible metrics for the analysis of problems with various design objective functions in decision‐making environments. The optimization problem considers decision variables associated with the sizing of units such as photovoltaic panels, wind turbines, thermal and electrical energy storage, wood‐fired boilers and the integration of food production systems involving aquaculture and local corn production. Water management is associated with domestic activities and crop irrigation.