bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective study of once-daily accelerated partial breast irradiation using 3-dimensional conformal external beam radiotherapy for Japanese women: 12-year outcomes, toxicity, and cosmesis
Authors: Takahashi Kana , Kagami Yoshikazu , Yoshimura Ryoichi , Morota Madoka , Murakami Naoya , Nakamura Satoshi , Okamoto Hiroyuki , Nagao Ayaka , Sakuramachi Madoka , Kashihara Tairo , Kaneda Tomoya , Inaba Koji , Okuma Kae , Nakayama Yuko , Itami Jun , Igaki Hiroshi 
Published: July 2024

Abstract

Background
To analyze in a prospective study the long-term safety and efficacy of 3-dimensional conformal radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI) for Japanese women with early breast cancer.
Methods
Breast cancer patients with pathological tumor size ≤ 3 cm, age ≥ 20 years, lumpectomy with at least a 5 mm margin, and ≤ 3 positive axillary nodes were eligible. APBI was delivered by 3D-CRT at a dose of 38.5 Gy in 10 fractions over 10 days. The primary endpoints were the frequency and severity of acute and late radiation toxicities, and secondary endpoints were local control, survival, and cosmesis. The sample size was determined based on the incidence of ≥ grade 3 acute and late radiation toxicities, which required 71 enrollments.
Results
Between 2008 and 2010, 73 patients enrolled in this trial. Twelve patients (16%) had 1–3 lymph node metastases. At a median follow-up of 12.6 years (range: 2.7–13.9 years), there were no cases of grade ≥ 3 acute or late toxicity. There were 4 ipsilateral breast tumor recurrence (IBTR) events: 12-year IBTR incidence was 4.4%. The difference in the incidence of IBTR between node-negative and node-positive patients was marginal (1.9% vs. 16.7%, p = 0.055). The majority of patients (95.8%) had excellent/good cosmesis.
Conclusions
APBI delivered with 3D-CRT is a feasible treatment option for Asian females, but it was indicated that node-positive status might increase IBTR risk.
QTL mapping of adult plant resistance for leaf rust in F 2:3 wheat pedigrees derived from Zhou mai 22/Chinese Spring
Authors: Kang Ling , Yu Tianhui , Qin Jinyan , Gebrewahid Takele Weldu , Liu Jialong , Chu Zhiying , Xi Jiaxin , Li Zaifeng , Yan Xiaocui , Yao Zhanjun 
Published: July 2024

Abstract

Wheat (Triticum aestivum L.) leaf rust [Puccinia triticina (Pt)] causes devastating yield losses globally. Conceivably, breeding and deployment of cultivars harboring adult plant resistance (APR) to leaf rust (LR) can be an effective way to manage wheat leaf rust. Particularly, mapping of major quantitative trait loci (QTLs) facilitate breeding of LR resistant cultivars. Here, we have mapped QTLs for APR to LR in wheat using wheat population including 215 F2:3 lines from a Zhoumai 22/Chinese Spring. Bulked segregation analyse (BSA) and simple sequence repeat (SSR) detection of wheat lines digged out the QTLs for APR to LR. Using Manager QTXb20 and Icimapping 3.2 software, some APR QTLs were mapped in Zhoumai 22/Chinese Spring wheat population. Three QTLs of APR to LR detected and designated QLr.zh-2BS, QLr.zh-4B and QLr.zh-7DS) explained 12.58–13.58%, 7.02–20.22% and 6.73–21.30% of the phenotypic variation, respectively. QLr.zh-4B and QLr.zh-7DS were derived from Chinese Spring wheat, whereas QLr.zh-2BS emanated from Zhoumai 22. QLr.zh-4B and QLr.zh-7DS were mapped close to Lr12 and Lr34, respectively, revealling their close link to these loci, correspondingly. Overall, the QTLs related APR to LR, their flanking markers and associated APR genes identified in this study could be useful to genomic resources and marker-assisted select breeding of LR resistance in wheat.
Assessing Spatiotemporal Patterns and Wind-Driven Dispersal of E.prolifera in the South Yellow Sea by Multi-Index Decision Fusion in South Yellow Sea, China
Authors: Luo Kai , Zuo Ping , Ma Qitong , Zheng Yujun , Li Xiruo , Chang Hu , Yan Yuru 
Published: July 2024

Abstract

Since 2007, the coastal areas of Shandong have frequently experienced green tides caused by Enteromorpha prolifera (E.prolifera). Our study utilized long-term MODIS remote sensing data and multi-index decision fusion technology to analyze the distribution of E.prolifera in the South Yellow Sea from 2008 to 2022. This approach enabled us to detail the spatiotemporal distribution, including data on centroid movement paths and coverage areas. Further application of Moran's Index for spatial autocorrelation analysis revealed four distinct drift patterns of E.prolifera, stretching from the coast of Jiangsu Province to the Shandong Peninsula. These patterns are significantly influenced by the wind speed and direction in the region, with the maximum centroid drift speed dependent on the wind's magnitude. Before 2018, the coverage area and distribution range of E.prolifera showed an exponential expansion trend. This research provides essential spatiotemporal data for understanding the drift dynamics and ecological impact of E.prolifera in the region.
Effect of different restorative design and materials on stress distribution in cracked teeth: a finite element analysis study.
Authors: Liu Ting , Liu Hong , Meng Jiali , Liu Yajing , Wei Yuan , Huang Yequan , Zhou Qian , Yang Weidong , Zhu Yanan 
Published: July 2024

Abstract

Objectives
To compare stress distribution and crack propagation in cracked mandibular first molar restored with onlay, overlay, and two types of occlusal veneers with two different CAD/CAM materials by Finite Element Analysis (FEA).
Materials and methods
A mandibular first molar was digitized using a micro-CT scanner. Three-dimensional dynamic scan data were transformed, and a 3D model of a cracked tooth was generated. Finite element models of four different models (onlay, overlay, and two types of occlusal veneer restored teeth) were designed. Two different CAD/CAM materials, including Lava Ultimate (LU) and IPS e.max CAD (EMX), were specified for both models. Each model was subjected to three different force loads on the occlusal surfaces. Stress distribution patterns and the maximum von Mises (VM) stresses were calculated and compared.
Results
Compared to the base model, all restorations showed high-stress concentration moved from the lower margin of the crack area towards the top of the crack area. The EMX-restored onlay, overlay, and occlusal veneer 2 had the lowest stress in the cracked area and the lowest average von Mises stress levels at the lower margin along the cracked line, especially under the 225N lateral force (P < 0.05). The occlusal veneer 1 filled with resin had a poorer stress distribution and higher stress concentration of stress at the remaining crack than the occlusal veneer 2 without resin filled inside.
Conclusions
The EMX restorations with onlay, overlay, and occlusal veneer 2 showed lower stress concentration at the crack surface's lower margin compared to the LU-restored models. The occlusal veneer with internal resin filler exhibited higher stress on the end of the lower margin of the crack surface.
Clinical relevance
Our results suggest that onlay, overlay ceramic restorations and occlusal veneer (without resin filling inside) may be a favorable method to prevent further crack propagation.
Real-time Optimized Inverse Kinematics of Redundant Robots Under Inequality Constraints
Authors: Zhang Linlin , Du Huibin , Qin Zhiying , Zhao Yuejing , Yang Guang 
Published: July 2024

Abstract

Inverse kinematics of redundant robots presents a challenging problem for real-time applications due to the lack of uniqueness of solution and the low computational efficiency caused by redundancy and hard limits. In this work, a general and efficient method for addressing the real-time optimized inverse kinematics of redundant robots is proposed, taking into account hard limits in joint and Cartesian space that can never be violated. The proposed method proceeds by using constrained linear programming instead of quadratic programming to solve the inverse kinematic problem. Various hard limits such as joint range, bounds on velocity and acceleration are handled explicitly as inequality constraints. This method resolves the redundancy in real-time and enable to simultaneously guarantee that the additional motion constraints will never be violated. Its performance allows real-time kinematic control of redundant robots executing sensor-driven online tasks. The effectiveness of this method is demonstrated through simulations and experiments conducted on a 7-DOF KUKA IIWA robot, showcasing its ability to control redundant robots executing sensor-driven tasks in dynamic environments with numerous hard limits.
Can Ki67 Serve as a Suitable Marker to Indicate the Necessity of Staging Diagnostics in Cases of Low-risk Breast Cancer?
Authors: Jung Lisa , Huwer Sarah Isabelle , Jungmann Peter , Medl Markus , Taran Florin-Andrei , Neubauer Jakob , Wilpert Carolin , Juhasz-Böss Ingolf , Müller Carolin 
Published: July 2024

Abstract

Background:
For many years, staging tests have not been routinely employed for low-risk early breast cancer (EBC). However, the role of Ki67 in determining the need for staging tests in low-risk EBC remains unclear. Our study aimed to assess the number and types of staging diagnostics, additional imaging, and false-positive results in low-risk EBC with low and high Ki67 (</≥ 25%).
Methods:
This is a retrospective, single institution cohort study. All patients with newly diagnosed low-risk breast cancer at the University Medical Center in Freiburg in 2017 and 2021 were included. Low-risk was defined as clinical tumor stage T1/2, node negative (N0), hormone receptor positive, HER2 negative, asymptomatic EBC. Information on demographics, clinical and pathological characteristics, as well as number and type of performed staging diagnostics was obtained. Also, rate of additional imaging or follow-up diagnostics due to suspicious findings was analyzed. The patients were divided into two groups (Ki67 < and ≥ 25%) and rates of distant metastases as well as performed staging diagnostics and false positive rates were compared.
Results:
A total of 189 patients with low-risk EBC were identified, with 54% (n = 102) having Ki67 < 25% and 46% (n = 87) having Ki67 ≥ 25%. Risk for distant metastases was 0% in Ki67 < 25% and 1.1% in patients with Ki67 ≥ 25% (p > 0,05, n.s.). Due to suspicious findings in the initial staging diagnostic, additional imaging was required for 11.8% (n = 12) of patients with Ki67 < 25% compared to 19.4% (n = 17) patients with Ki67 ≥ 25% resulting in a false positive rate of 11.8% (Ki67 < 25%) and 18.3% (Ki67 ≥ 25%), respectively.
Conclusion:
Distant metastases are rare in low-risk EBC. All in all, staging diagnostics should not be routinely employed in this patient population. Only patients with high Ki67 developed distant metastases. In these cases, staging diagnostics may be discussed with the patient.
Safety and Efficacy of Latitud™ Hip Replacement in Total Hip Arthroplasty: An Observational Study in Kazakhstan Running title: Safety and Efficacy of Latitud ™ Hip Replacement
Authors: Bekarissov Olzhas , Batpen Arman , Belokobylov Aleksey , Baidalin Timur , Oktyabrova Durdana , Beknazarov Askarjan , Petrovskiy Konstantin , Shetty Kiran Kumar 
Published: July 2024

Abstract

Introduction: Total hip replacement (THR) is one of the most successful surgical procedures globally for managing end-stage hip osteoarthritis. Latitud™ hip replacement system is at the forefront of restoring mobility and improving patient outcomes. This study aimed to evaluate the safety and effectiveness of the Latitud™ hip replacement in total hip arthroplasty. Methods: In this retrospective, single-centre, post-market, observational study, 150 patients who underwent total hip replacement and were treated in our hospital from 2018–2020 were included. The primary outcome was the THR-related intra and postoperative complications and revision rate at 1-year follow-up. Secondary outcomes were other patient-reported outcomes, radiographic analysis, Harris hip score, adverse events, implant dislocation, and survivorship rate. Results: The mean age of the patients was 53.90 ± 11.44 years. The surgical procedures were successful without any major complications. There was a significant (p < 0.001) improvement in the Harris hip score. No death was observed throughout the study. There was 1 (0.67%) intra-operative fracture, with the patient having a closed comminuted fracture of the upper and middle third of the left femur and anemia. Seven patients (4.67%) patients required postoperative blood transfusions. During the follow-up period, there was no revision surgery or implant dislocation. Conclusion: This observational study suggests that the Latitud™ hip replacement system was favorable safety and effective in a real-world setting in Kazakhstan. The study showed promising results in pain alleviation, functional improvement, and implant survivorship.
Sensorless of Switched Reluctance Motor Based on Inductance Characteristic Point Under Magnetic Saturation
Authors: CAI Hui , FAN Yuhua 
Published: July 2024

Abstract

This paper presents a method of rotor position estimation for switched reluctance motors suitable for saturation. The effects of saturation as well as voltage changes are taken into account at the same time. It is based on the inductance in the unsaturated region. When the phase inductance is equal to the threshold, it is defined as a feature point. Meanwhile the feature pulse signal is triggered. Different inductance intersection thresholds are determined when the phase current and bus voltage change. The rotor position is estimated by interval speed. Compared with the traditional inductance method, the position estimation error is smaller. Finally, the correctness and effectiveness of the proposed method are verified by simulation and experiments.
Genomic analysis of Escherichia phage CMSTMSU isolated from shrimp farm effluent water
Authors: Lelin Chinnadurai , Thirumalaikumar Eswaramoorthy , Uma Ganapathi , Anusha Radha John , Sayan Paul , Sudhakar Sivasubramaniam , Citarasu Thavasimuthu 
Published: July 2024

Abstract

Background
Escherichia phage CMSTMSU which isolated from shrimp farm effluent water was sequenced the whole genome and find out the gene ontology, predicted protein statistics, enzyme classes and predicting the secondary structure analysis of protein etc. Bioinformatics tools like CANU algorithm for interpretation of incomplete assemblies, Blast2GO tools to study the Gene Ontology, Mauve system for constructing multiple genome alignments related to evolutionary events Rapid annotation using subsystems technology (RAST) used to annotate protein sequences and Iterative Threading Assembly Refinement (I-TASSER) used protein secondary structure prediction were carried out.
Results
According to sequencing results, the genome's average read length was found to be 3.4 Kb, with a total of 88676 reads observed. A single contig with 35.6% GC content and a genome size of 386.4 kb was produced by the CANU assembly. 767 genes and 700 proteins were annotated, according to the BLAST2GO mapping, and BLAST hits demonstrated sequence similarity of at least 70% to the known protein sequences in the nr database. A study of the KEGG pathway revealed that 18 sequences were involved in the metabolism of thiamine, 26 sequences in the metabolism of pyrdimine, and 37 sequences in the metabolism of purines. Escherichia phage CMSTMSU was found to be closely related to Escherichia PBECO 4, Escherichia Phage 121Q, and Escherichia phage vB Eco slurp01, according to MAUV alignment. Escherichia phage CMSTMSU protein was found to have a close relationship with other phages, such as Salmonella phage munch, Klebsiella phage vB KleM RaK2, and Cronobacter phage CsaM GAP32, according to secondary structure prediction.
Conclusions
Compared to other reference phages in our study, it is noteworthy that the newly isolated phages' large genome sequences have the potential to spark curiosity from a biological standpoint.
A practical index system forevaluating the core competence of specialized nurses in digestive endoscopy
Authors: Li Chao , Du Xufang , Tian Xiangyan , Yao Jia , Tian Shuchuan 
Published: July 2024

Abstract

Aim To construct the evaluation index system of the core competence of digestive endoscopy nurses and provide reference for the training and evaluation of endoscopy nurses.
Background Digestive endoscopy nurses play a crucial role in the process of endoscopic diagnosis and treatment, and specially trained nurses can improve the safety of digestive endoscopy surgery.
Methods Following a thorough review of pertinent guidelines, expert opinions, and literature pertaining to the diagnosis and treatment of digestive endoscopy, a preliminary set of core competency evaluation indicators for digestive endoscopy nurses was established through group deliberation. Subsequent refinement of these indicators and their respective weights was achieved through two rounds of delphi expert consultation and the application of the analytic hierarchy process, resulting in the finalization of the evaluation index system.
Results In the two rounds of letter inquiry, the authority coefficient of experts was 0.865 and 0.875 respectively, and the coordination coefficient of Kendall of the second round was 0.152,0.243 and 0.334 (P<0.05).The final core competence evaluation indexes included 5 first-level indexes, 11 second-level indexes and 48 third-level indexes.
Conclusion The core competence evaluation index system is characterized by a high degree of scientific rigor and reliability, effectively capturing the essential competencies necessary for the role of digestive endoscopy nurses. This system serves as a valuable tool for enhancing post-competence and elevating the overall quality of nursing care, offering a sound basis for improvement in clinical practice.
Advanced Quantum-enhanced Recurrent Neural Network for Efficient Spectrum Sensing in Cognitive 5g Networks
Authors: PERUMAL RAMAKRISHNAN 
Published: July 2024

Abstract

Spectrum sensing plays an important role in cognitive 5G network for efficient spectrum utilization. The existing spectrum sensing techniques has limitations in terms of low detection accuracy and high computational complexity. To overcome this limitation, a novel model is presented utilizing the benefits of deep learning and optimization algorithms. The proposed model incorporates a novel Quantum Inspired Recurrent Neural Network (QI-RNN) optimized using Hybrid Elephant Herding Bat algorithm (HEH-BA). The proposed QI-RNN utilize quantum principles like superposition and entanglement to improve the learning efficiency and capture complex patterns in spectrum data. Further to improve the performance, the hybrid optimization model combines the global search abilities of elephant herding optimization with local search refinement of bat algorithm. This ensures that the proposed model provides better balance between exploration and exploitation in the hyperparameter space. The experimental results of the proposed model demonstrates that QI-RNN with HEH-BA performs better than traditional Adaptive Wideband Spectrum Sensing (AWBSS), Multi-task Compressive Sensing (MCS-FAM), Convolutional Neural Networks (CNN), and Deep Belief Networks with Sunflower Optimization (DBN-SFO) models. The proposed model high detection probability of 97% with reduced false alarm of 0.01 and energy efficiency of 97% provides a significant improvement in performance and reliability in spectrum sensing.
Assessing Cost and Cost Savings of Teleconsultation in Long-Term Care Facilities: A Time-Driven Activity-Based Costing Analysis within a Value-Based Healthcare Framework
Authors: Nabelsi Véronique , Plouffe Véronique 
Published: July 2024

Abstract

Background
Quebec's healthcare system faces significant challenges due to labour shortage, particularly in long-term care facilities (CHSLDs). The aging population and increasing demand for services compound this issue. Teleconsultation presents a promising solution to mitigate labour shortage, especially in small CHSLDs outside urban centers. This study aims to evaluate the cost and cost savings associated with teleconsultation in CHSLDs, utilizing the Time-Driven Activity-Based Costing (TDABC) model within the framework of Value-Based Healthcare (VBHC).
Methods
This study focuses on CHSLDs with fewer than 50 beds in remote regions of Quebec, where teleconsultation for nighttime nursing care was implemented. Time and cost data were collected from three CHSLDs over varying periods. The TDABC model, aligned with VBHC principles, was applied through five steps, including process mapping, estimating activity times, calculating resource costs, and determining total costs.
Results
Teleconsultation increased the cost per minute for nursing care compared to traditional care, attributed to additional tasks during remote consultations and potential technical challenges. However, cost savings were realized due to reduced need for onsite nursing staff during non-eventful nights. Overall, substantial savings were observed over the project duration, aligning with VBHC's focus on delivering high-value healthcare.
Conclusions
This study contributes both theoretically and practically by demonstrating the application of TDABC within the VBHC framework in CHSLDs. The findings support the cost savings from the use of teleconsultation in small CHSLDs. Further research should explore the long-term sustainability and scalability of teleconsultation across different CHSLD sizes and settings within the VBHC context to ensure high-value healthcare delivery.
Translocated southern seedlings perform as well as local provenances: insights from an ecophysiological monitoring under varying cutting modalities
Authors: Dumais Daniel , Raymond Patricia , Champagne Emilie 
Published: July 2024

Abstract

Forest assisted migration, the human-mediated movement of tree populations or species, is an adaptive silvicultural tool that could help forest transition to future climate while maintaining their productivity and ecosystem services. However, we need additional knowledge about the physiology of translocated seedlings to select the most appropriate species, provenances (i.e., seed sources) and silvicultural treatments surrounding this adaptive strategy. We used the first experimental site of the DREAM Network to assess early ecophysiology of local and translocated seedlings of eight species (Prunus serotina, Quercus rubra, Acer saccharum, Picea glauca, Picea rubens, Pinus strobus, Pinus resinosaand Thuja occidentalis). Seedlings were planted in a mixed plantation design in patch clearcut and in regular shelterwood system. For each species, seedlings were produced from three geographical provenances representing current climate (2018), mid-century and end-century climates (predicted for 2050 and 2080), based on climate analogues. Shelterwood partial cover proved useful during the establishment (e.g., to protect seedlings from late frost) with limited impacts on physiological performance. When planted in patch clearcut, Prunus serotina, Quercus rubra and Acer saccharum from mid-century and end-century climate analogues experienced lower water stress, suggesting a better drought tolerance than those from local provenances. Overall, insights from this ecophysiological monitoring indicated that translocated southern seedlings perform as well as or better than local provenances, suggesting that they can acclimate to their new destination site.