bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bibliometric Analysis in Publications of Neural Tube Defects in Latin America from 2000-2023
Authors: Vilca-Salas Martha I. , Rios-Garcia Wagner , Salas Marcos T. Vilca , Paucar-Anccasi Angie Andrea , Garcia-Sandoval Flavio Anghelo 
Published: August 2024

Abstract

Background
Neural tube defects (NTD) are one of the most common congenital defects in the world and have a high prevalence in low-income regions like Latin America. Despite their prevalence, research output on NTDs in Latin America is limited due to inadequate policies and investment in research. We present a bibliometric analysis of scientific publications on NTDs in Latin America from the year 2000 to 2023.
Methods
This bibliometric analysis examines scientific publications on NTDs in Latin America from 2000 to 2023, utilizing the Scopus database. Articles were selected based on their relevance to NTDs and the affiliation of at least one author to a Latin American institution. Data analysis was conducted using R's bibliometrix package and VOSViewer for visual analysis.
Results
A total of 722 articles were identified, primarily published in English (78.95%), with Brazil, Mexico, and Chile being the countries with most publications. The institutions with more publications were primarily located in Brazil, with the University of Sao Paulo being the top contributor. Collaborative networks were strongest between Brazil and the United States. The journal with highest quantity of publications was "Child’s Nervous System". The average number of citations per article was 13.51, with studies on folic acid fortification and genetic factors being the most cited.
Conclusions
This study provides a comprehensive overview of NTD research in Latin America, emphasizing the importance of regional risk factors and prevention policies.
Atypical Hemolytic Uremic Syndrome, a Possible Leukocyte Extravasation Disorder, case report and review of literature
Authors: Zsidisin George Nicholas 
Published: August 2024

Abstract

Using specific clinical analyses, including genetic, hemolytic, and blood, an in-depth review of the research and disease manifestations leads to a unique hypothesis about our patient’s atypical hemolytic uremic syndrome pathophysiology. Notably, a novel C3 defect, in addition to a common factor B mutation, leads to doubt over current theories of alternative complement overactivation and further drives focus onto the thrombotic nature of the disease. We propose a pathology of defective platelet-leukocyte-endothelial adhesions, leading to poor leukocyte extravasation.
Unveiling Hidden Risks: Obstetrical Complications in Endometriosis Associated Infertility Post-Laparoscopic Surgery
Authors: Lin Shunhe , Chen Qingshan , Liu Chaobin , Lin Guan , Huang Penghui , Qi Wei , Xie Xi , Wang Zhenna , Guo Yuyan 
Published: August 2024

Abstract

Objective
This study aims to elucidate the spectrum of obstetrical complications in patients with endometriosis-associated infertility following complete laparoscopic excision of endometriosis lesions, and to assess the impact of endometriosis severity on these outcomes.
Study design:
This case-control study enrolled 151 women who underwent laparoscopic surgery for endometriosis-associated infertility at Fujian Maternity and Child Health Hospital between January 2014 and September 2020, and who subsequently gave birth to a singleton at the same hospital by September 2021. Participants were divided into a stage I–II endometriosis group (n = 88) and a stage III–IV endometriosis group (n = 63). A control group consisted of 302 women without endometriosis who delivered a singleton at the same hospital during the same period. Clinical data and complications during pregnancy, delivery, and the neonatal stages were collected from the hospital’s medical record system.
Results
After adjusting for confounding factors, women in the stage I–II endometriosis group had a significantly higher risk of gestational diabetes mellitus (GDM) (P = 0.004) and cesarean section (P = 0.027) compared to the control group. Women in the stage III–IV endometriosis group exhibited a higher risk of GDM (P = 0.048) and premature rupture of membranes (P = 0.039). No statistically significant differences were observed in other obstetrical complications between the endometriosis and control groups.
Conclusions
Women with a history of stage I–II endometriosis who have undergone laparoscopic conservative surgery face a higher risk of GDM and cesarean section during pregnancy. Those with a history of stage III–IV endometriosis are at an elevated risk of GDM and premature rupture of membranes. These findings underscore the need for heightened monitoring and management of pregnancies in women with prior endometriosis.
Research on the development level and technology-driven efficiency of the intelligent international shipping center development
Authors: lianhua liu , Shiqi Lyu , Zexian chen , xiu chen 
Published: August 2024

Abstract

Firstly, this paper introduces a new concept of intelligent international shipping center, and its characteristics are: ① intelligent shipping industry technology; ② knowledgeable shipping service; ③ intelligent shipping industry chain. Secondly, the paper constructs an evaluation model for the development capacity of intelligent international shipping centers, and evaluates the seven major international shipping centers in Guangzhou, Hong Kong, Shenzhen, Shanghai, Tianjin, Dalian and Lianyungang. The empirical results show that the development capacity of the major international shipping centers has been improved with the passage of time, among which, Shanghai's development ability has always been in the lead, and some international shipping centers lack of potential of continuous development. We need to consider the input factors. Then, further discusses the impact of technology input factors on the development of international shipping center. This paper uses DEA combined with Malmquist index to study, and the results show that technological progress is the main driving force to promote the development of international shipping cente. Finally, this paper puts forward three suggestions for improvement:①pay attention to the application of new technology to improve the intelligent level,Focus on the application of new technologies.②promote the knowledge transformation of shipping business and improve the intelligent ability.③integrate the upstream and downstream shipping industry and coordinated development of the shipping industry ecosystem.
Comprehension for Breast Awareness, Dense Breast, and Hereditary Breast and/or Ovarian Cancer (HBOC) in participants of Breast Cancer Screening
Authors: Nakagomi Hiroshi , Teramoto Katsuhiro , Nakada Haruka , Matsuda Kei , Yoneyama Ryoko , Kawai Chiemi , Miura Yoshinari , Kunugi Chiemi , Hirose Junji , Yoda Yoshioki 
Published: August 2024

Abstract

Background: It is important to promote breast awareness (BA) as an alternative to breast self-examination in order to improve the prognosis of breast cancer patients.
Methods: We investigated the level of comprehension for BA among participants of the organized (n=7959) and the opportunistic (n=11541) breast cancer screening. In addition, we investigated the level of comprehension for dense breast (DB) and hereditary breast and/or ovarian cancer (HBOC) as knowledge necessary for optimal breast cancer screening.
Results: The overall percentages of comprehension of BA, DB and HBOC were 24, 32, and 24%, respectively. The level of comprehension of BA, DB, and HBOC was lower among participants aged <49 years compared to those aged >50 years. First-time participants were less likely to be aware of BA, DB, and HBOC than those who had screening for the second time or more. On the other hand, there was no difference in the level of comprehension of BA between organized and opportunistic screening, but the level of awareness of BD and HBOC was significantly higher in participants of opportunistic screening.
Conclusions: The level of comprehension for BA, DB and HBOC is still low in 2023. Our results indicates that screening is an important opportunity to educate something about the breast health literacy. We intend to conduct this survey and educational campaign over time to determine if those comprehension improve.
Establishment and characterization of a new mouse gastric carcino-ma cell line, MCC
Authors: Wang Yushen , Li Xianju , Wang Yi , Qin Jun 
Published: August 2024

Abstract

Background
The aim of this study was to establish a primary mouse gastric carcinoma cell line.
Methods
Gastric adenocarcinoma in the body region was induced in immunocompetent BALB/c mice using N-Methyl-N-nitrosourea and a 2% NaCl solution. Fresh gastric cancer tissue samples were cultured in 1640 medium supplemented with 10% fetal bovine serum for primary culture and subculture. Cellular morphology was assessed via light microscopy, and a cell growth curve was established. Genomic and proteomic analyses were conducted to characterize the molecular features of the cell lines. This cell line demonstrated a 100% success rate in forming subcutaneous tumors in BALB/c mice. By integrating proteomic profiles from clinical gastric cancer patients and the murine subcutaneous tumor model, several molecular targets suitable for preclinical investigation were identified. Trametinib, a MEK inhibitor, was employed as a model compound in our preclinical study.
Results
A novel gastric carcinoma cell line, designated MCC, was established from BALB/c mice. This cell line exhibited a doubling time of approximately 33 hours. Genomic and proteomic analyses identified mutations frequently observed in clinical gastric cancer patients, such as Kras, Egfr, and Ccnd3. Additionally, MCC overexpresses proteins, including SLC1A5, MCC6, and ITGA2, which are significantly upregulated in gastric cancer tissues compared to adjacent non-cancerous tissues. The MCC cell line demonstrated stable tumorigenicity in immunocompetent BALB/c mice, forming subcutaneous tumors that closely resemble the proteomic profile of clinical gastric cancer samples. This high concordance facilitated the identification of several potential therapeutic targets for gastric cancer. Preclinical studies with trametinib revealed that treatment effectively inhibited gastric cancer growth, likely mediated through the activation of immune cells, particularly neutrophils and T cells.
Conclusions
The MCC cell line is a valuable tool for gastric cancer research, enabling studies of cancer development, progression, and metastasis, and providing a robust platform for evaluating therapeutic strategies and drug efficacy. Its strong tumorigenicity and high correlation with clinical proteomic profiles underscore its relevance in translational research, aiding in the identification of novel therapeutic targets and molecular pathways for effective treatments.
High CD38 expression defines a mitochondrial function adapted CD8 + T cell subset with implications for lung cancer immunotherapy
Authors: Lv Leilei , Zhai Jia-wei , Wu Jia-juan , Fan Gui-qin , Zhang Yao-xin , Shen Yu , Qu Qiu-Xia , Chen Cheng 
Published: August 2024

Abstract

Despite identifying specific CD8+T cell subsets associated with immunotherapy resistance, the molecular pathway triggering the process remains elusive. Given the potential of CD38 in regulating CD8+T cell function, we aimed to observe the accumulation of CD38+CD8+T cells in lung cancer and further explored its role in immunotherapy resistance. Phenotypic analysis of tumoral CD8+T cells from both lung cancer patients and immunotherapy-resistant pre-clinical models identifies that CD38-expressing CD8+T cells displayed as CD38hi and CD38intT cell subsets. Following, it was observed a higher expression of CD38 along with T cell exhaustion genes and dysregulated mitochondrial bioenergetics. In addition, it was suggested that an evaluated CD38hiCD8+T cells in peripheral but not in center of TME were associated with good response to anti-PD-1 therapy in NSCLC, as well as corresponding depth of clinical regression, which was evidenced by more depletion of CD38hiCD8+T cells occur in subject with higher regional CD38hiCD8+T cells infiltration. As expected, it was found that ICIs-resistant murine lung cancer models had lack of effective reduction in term of CD38hiCD8+T cells when receiving PD-L1 mAb alone. Notably, combination therapy of PD-L1 mAb and EGCG could selectively restrict CD38hiCD8+T cells infiltration and enhance IFN-γ production by these T cells, thereby significantly improved survival in this carcinoma model. This restored immunotherapy sensitivity was found to be related to the selective improved mitochondrial of CD38hiCD8+T cells, which was validated by the established link between IFN-γ production and mitochondrial metabolism. Collectively, our data highlighted a role for the CD38-coupled dysfunctional mitochondrial in promoting CD8+T cell exhaustion and intrinsic resistance to ICIs therapy, thereby offered a rationale target to enhance the therapeutic efficacy of PD-1 blockade therapy in lung cancer.
Oriental Stock Prediction Approach(OSPA): A Model for Stock Price Prediction Utilizing the Capacity of Time Series Analysis
Authors: Verma Pawan , Kumar Mohit , Verma Sahil , Gulhane Monali , Rakesh Nitin , Jhanjhi NZ , Khurma Ruba Abu , Shah Mohd Asif , Mallik Saurav 
Published: August 2024

Abstract

This paper delves into the intricate world of financial markets, where accurate prediction of stock prices plays a pivotal role in guiding investment strategies and financial decision-making. In an era dominated by vast amounts of data, the application of advanced time series analysis models has become increasingly critical for extracting meaningful insights from market trends. This paper explores the efficacy of various deep learning models, including Long Short-Term Memory (LSTM), Bidirectional LSTM (BiLSTM), Gated Recurrent Unit (GRU), and an enhanced version of GRU (Improved GRU), in predicting stock prices. Through rigorous evaluation, the paper demonstrates that the Improved GRU model outshines its counterparts in forecasting accuracy, as evidenced by its superior performance across multiple evaluation metrics such as Mean Squared Error, Mean Absolute Error, Root Mean Squared Error, and R-squared Score. The implications of these findings are vast, suggesting that the Improved GRU model can serve as a powerful tool for investors and financial analysts seeking to navigate the complexities of the stock market with greater precision. Furthermore, the study opens up new avenues for future research, emphasizing the need for further enhancements in prediction models through the integration of more granular data sources, exploration of hybrid models, and the application of machine learning techniques to understand the multifaceted dynamics of financial markets better. This paper not only advances our understanding of stock price prediction models but also sets the stage for the development of more sophisticated and accurate forecasting tools in the field of financial time series analysis.
Potential of Rice Husk Bio-char as a Sustainable Soil Fertilizer Alternative
Authors: Yusop Nur Aqidah Mat , Md Umi Fazara , Ahmad Syahirah Faraheen Kabir 
Published: August 2024

Abstract

This study was conducted to test the effectiveness of biochar rice husk as an alternative fertilizer for the growth of mustard greens. There are four treatments used in this experiment, where CK is the control, BRH10 is rice husk biochar with 10% mixing rate (w/w), BRH30 is rice husk biochar with 30% (w/w) mixing rate and BRH50 is rice husk biochar with 50%(w/w) mixing rate. There are two types of soil used in the study labelled as Soil A (silty loam soil) and Soil B (sandy clay loam). Several analyses have been done to identify the suitability of biochar to be used as soil fertilizer including determining functional groups, morphology, pH, elements, height and weight. The results of the study showed that the crop yield obtained for height and weight measurement in the BRH10 treatment is the best, which is 7.9 cm and 0.4477 g. Based on the results of soil pH, SEM analysis and elemental analysis, it showed that the biochar is suitable for the cultivation of mustard greens and showed the ability to increase soil fertility. In conclusion of this study is that the BRH10 treatment for soil B has a better effect on the growth of mustard green plants compared to soil A and other treatments. Therefore, this biochar rice husk is suitable as an alternative fertilizer but should be used in less quantities.
Learnings from Conducting Online Surveys in India During the COVID-19 Pandemic
Authors: Kashyap Shubhangi , Velleman Richard , Singh Soumya , D’Souza Ethel , Gaikwad Leena , Bhatia Urvita , Nadkarni Abhijit 
Published: August 2024

Abstract

When traditional research data collection methods were stalled due to the COVID-19 driven large-scale lockdown across India, it led to a sharp rise in the use of digital platforms to collect research data. In 2020, we launched three online surveys (including cross-sectional and longitudinal surveys) aimed at understanding the mental health concerns and needs of different populations in India. This paper presents the learnings from conducting these surveys and highlights the experience of our team with respect to different phases of the studies such as conceptualisation, development, recruitment, and dissemination. Our key findings are that: collaboration with relevant organisations was the most effective method for mass dissemination and recruitment; despite an aim of wide recruitment, survey recruitment came primarily from known networks; if aiming for recruitment via significant social media dissemination, then translation into regional languages was not effective on its own; and the visual design, user interface, and ease of language play a key role in making the survey accessible, inclusive, and easy to navigate. Based on these learnings, we present recommendations for the planning and execution of online surveys in low-resource settings.
Physical and Cognitive Performance Impairment with Cannabis Consumption in Adults Over 12 hours
Authors: Abu-Ashour Waseem , Wahl Michael , Anvar Saman Hadjizadeh , Bahrami Mohammadmahdi , Zahiri Ali , Aragão-Santos Jose Carlos , Weber John T. , Behm David G 
Published: August 2024

Abstract

Background
Assessing the impact of cannabis on cognitive and physical performance is imperative, especially in safety-sensitive environments. This study investigated the degree and duration of performance impairment after cannabis consumption.
Methods
Fourteen cannabis users were subjected to physical and cognitive testing before and after smoking cannabis. Tests included assessment of intoxication, vital signs, psychomotor abilities, and muscle function. Blood, urine and saliva were analyzed for Delta-9-tetrahydrocannabinol (THC) and Carboxy-THC at baseline, and 1-, 6-, and 12-hours post-consumption.
Results
Blood THC levels peaked significantly at 1 hour and declined by 6 hours (p < 0.001), whereas Carboxy-THC levels showed a less pronounced but consistent variation over time (p = 0.005). Urine Carboxy-THC levels displayed a non-significant similar trend (p = 0.068). Acute cannabis use significantly (p = 0.01 – p < 0.001) raised systolic blood pressure and heart rate, increased force variability, reduced rate of force development, and compromised balance and muscle endurance up to 12 hours post-consumption.
Conclusions
Acute cannabis consumption results in physical impairments, impacting essential functions required for safety-sensitive tasks. The sustained presence of Carboxy-THC indicates prolonged pharmacological effects and necessitates cautious policy-making for workplaces.
Trial Registration
This study was not registered as a clinical trial as the ClinicalTrials.gov indicates that the study must answer yes to all four questions on their checklist. Although, our study was interventional, it was not conducted in the US nor involved a new FDA investigational new drug application, and the cannabis was not manufactured or exported from the US. The focus of the study was on the recreational use of a single cannabis cigarette on subsequent physiological or work performance and safety measures over 12 hours.
Between Walls and Wilds: Myocastor coypus Abundance and Ocurrence in Gated and Open Communities Buenos Aires, Argentina
Authors: Araos Florencia Abdenur , Cavia Regino , Corriale María José 
Published: August 2024

Abstract

Urban development changes landscapes and creates new environmental conditions, causing local wildlife to either become extinct or expand to new areas. An example is the Myocastor coypus, are increasingly establishing themselves in urban habitats, even within its natural distribution range. This species has the potential to impact crop production and natural vegetation, generating conflicts with humans. In the Conurbano Bonaerense, the construction of gated communities creates new niches for this species. This study aimed to analyze how the main characteristics of urban developments in the Conurbano Bonaerense (type of urbanization and water body and geographical location) are associated with the abundance and occurrence of M. coypus. Sampling was conducted during 2021–2022 and 2022–2023 in the peak activity season of the species, in open and gated communities across the Conurbano Bonaerense, covering approximately 3,680 km². The presence of the species and its signs of activity were recorded in 331 transects along streams and ponds at 24 sampling sites evenly distributed. The occurrence and abundance were higher in gated communities (p < 0.05). Furthermore, the occurrence of the species was higher in lentic water bodies compared to lotic water bodies (p < 0.05). The probability of the species reaching pest levels per transect was 0.62 (95% CI = 0.26–0.98) of gated communities, while in open communities, it was only 0.1 (95% CI = 0-0.2). These results emphasize the need for a multidisciplinary approach to develop management strategies and deepen the study of the species ecology at a local level.
Assessing GPT and DeepL for Terminology Translation in the Medical Domain: A Comparative Study on the Human Phenotype Ontology
Authors: NOLL Richard , BERGER Alexandra , KIEU Dominik , MUELLER Tobias , BOHMANN Ferdinand , MÜLLER Angelina , HOLTZ Svea , STOFFERS Philipp , HOEHL Sebastian , GUENGOEZE Oya , ECKARDT Jan-Niklas , STORF Holger , SCHAAF Jannik 
Published: August 2024

Abstract

Background
This paper presents a comparative study of two state-of-the-art language models, OpenAI's GPT and DeepL, in the context of terminology translation within the medical domain.
Methods
This study was conducted on the Human Phenotype Ontology (HPO), which is used in medical research and diagnosis. Medical experts assess the performance of both models on a set of 120 translated HPO terms, employing a 4-point Likert scale (strongly agree = 1, agree = 2, disagree = 3, strongly disagree = 4). An independent reference translation from the HeTOP database was used to validate the quality of the translation.
Results
The average Likert rating for the 120 selected HPO terms was 1.29 for GPT-3.5 and 1.37 for DeepL. The comparison with HeTOP revealed a high degree of similarity between the machine translations and the reference translations.
Conclusions
The results indicate that both GPT and DeepL are effective at translating HPO terms from English to German. Statistical analysis revealed no significant differences in the mean ratings between the two models, confirming their comparable performance in terms of translation quality. The study not only illustrates the potential of machine translation but also shows incomplete coverage of translated medical terminology. This underscores the relevance of this study for cross-lingual medical research. However, the evaluation methods need to be further refined, and specific translation issues need to be addressed.