bluuebunny/crossref_metadata_2025_split huggingface dataset:
The uric acid/albumin ratio might be a better indicator for predicting repeat revascularization in young patients with acute coronary syndrome: Beyond inflammatory biomarkers
Authors: Oflar Ersan , Karabulut Dilay , Yıldız Cennet , Sinoplu Hasan Ali , Dönmez Esra , Koyuncu Atilla , Özcan Sevgi , Çağlar Nihan Turhan 
Published: August 2024

Background
Despite advancements in percutaneous and surgical revascularization techniques, nearly 20% of patients who undergo myocardial revascularization need repeat revascularization. Recently, identified as a prognostication factor for adverse cardiovascular events, the uric acid/albumin ratio (UAR) serves as a new marker for assessing inflammation and oxidative stress. Our objective was to investigate the association between UAR levels and repeat revascularization in young patients with acute coronary syndrome (ACS).

Methods
We enrolled 371 patients with ACS who were under the age of 55 years and who had previously undergone primary percutaneous coronary intervention. Due to their recurrent symptoms, these patients underwent subsequent coronary angiographic examination. The study cohort was splitted into two groups based on whether repeat revascularization was needed.

Results
The study and control groups consisted of 99 and 272 patients, respectively. The mean age of the patients in the study cohort was 41.99±4.99 years. Patients who needed repeat revascularization, in comparison to those who did not, exhibited significantly greater levels of the UAR and uric acid, along with lower levels of neutrophils, stent diameter and high density lipoprotein-cholesterol. Additionally, they had more complex disease, as described by the SYNTAX score. To identify the influential factors associated with repeat revascularization, multivariate logistic regression was performed. SYNTAX score, stent diameter, uric acid levels and the UAR were predictive of the need for repeat revascularization.

Conclusions
UAR was found to be an inexpensive, easily accessible marker for identifying young patients with ACS requiring repeat revascularization.
Investigation of the knowledge, attitudes, and perceptions regarding the utilization of rosemary among the population in Jordan
Authors: Thiab Samar , Nassar Razan I. , Alamleh Saif Alislam , Aboqubo Abdullah , Aljebori Abdullah 
Published: August 2024

Background
Rosemary (Rosmarinus officinalis) has a rich historical use for various reasons due to its beneficial characteristics including stimulating hair growth, providing antioxidant and antibacterial effects, and functioning as a skin conditioner and fragrance enhancer. The plant is cultivated in Jordan and using it is gaining popularity among the population.

Aim of the study
To assess the knowledge, attitude and perception of rosemary use among Jordanians.

Materials and methods
A cross-sectional study was conducted targeting at least 385 participants via social media platforms. Face and content validity of the questionnaire was performed by independent researchers. The questionnaire was divided into three main sections including the demographics section, the knowledge section and the attitude toward rosemary use. Statistical analysis was conducted using SPSS including descriptive statistics, chi-square tests, and multiple linear regression.

Results
The study’s participants (n = 407) had a mean age of 30.98 years old (SD = 12.76). The mean knowledge score for the participants ranged from -5 to 7, with a mean of 2.96 (SD = 2.61), with younger participants exhibiting higher knowledge scores regarding rosemary. Approximately half of the participants (48.2%) reported using rosemary for medical purposes. About three-quarters reported using rosemary oil, but a higher percentage reported using the leaves. Around three quarters administered it orally or applied it topically. Most participants obtained rosemary by growing it at home or from herbalists. Family and friends were the main influencers for rosemary users. Most of the study participants strongly agreed/agreed that plants possess a healing power (94.4%). The most reported reason for using rosemary was improving the hair condition (82.1%) followed by gastrointestinal problems (67.9%).

Conclusions
The study highlights the widespread use of rosemary for different reasons through different methods of application. Addressing misconceptions and enhancing knowledge dissemination may allow informed decision-making and promote the safe and effective use of herbal therapies.
Zinc and thyroid cancer: A systematic review and meta-analysis protocol
Authors: Soares Aline Alves , Nagashima Yasmin Guerreiro , Alves Camila Xavier , de Medeiros Kleyton Santos , Lopes Márcia Marília Gomes Dantas , Brandão-Neto José 
Published: August 2024

Introduction
The thyroid cancer has the ninth larger incidence of cancer in the world. Investigations related to the exposure to metals have become important due to the sensibility of the thyroid gland to them. Studies reveal that carcinogenic progressions are associated to the deficiency of the essential trace elements. In this context, the zinc is highlighted, essential for the metabolism of the thyroidal hormone and has a potential relation with the pathogenesis of the thyroid cancer. The objective of this systematic review and meta-analysis is to evaluate the low serum zinc as a risk factor for thyroid cancer in adults.

Methods and analysis
PubMed/MEDLINE, Scopus, Embase and LILACS databases will be searched for observational studies investigating the low serum zinc as a risk factor for thyroid cancer in adults. No language or publication period restrictions will be imposed. The primary outcome will be that the low serum zinc is a risk factor for thyroid cancer. Three independent reviewers will select the studies and extract data from the original publications. The risk-of-bias will be assessed by using the Newcastle-Ottawa Quality Assessment Scale (NOS). Data synthesis will be performed using the R software (V.4.3.1) and to assess heterogeneity, we will compute the I2 statistic and the results will be based on either random-effects or fixed-effects models, depending on the heterogeneity. The Grading of Recommendations, Development, and Evaluation (GRADE) system will be used to evaluate the reliability and quality of evidence.

Prospero registration number
International Prospective Register of Systematic Reviews (PROSPERO) CRD42023463747.
Similar recurrence after curative treatment of HBV-related HCC, regardless of HBV replication activity
Authors: Kim Mi Na , Kim Beom Kyung , Cho Heejin , Goh Myung Ji , Roh Yun Ho , Yu Su Jong , Sinn Dong Hyun , Park Soo Young , Kim Seung Up 
Published: August 2024

Background and aims
Antiviral therapy (AVT) is required in patients with newly diagnosed hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), if HBV DNA is detectable. We compared the risk of recurrence according to HBV replication activity at the curative treatment of HBV-related HCC.

Methods
Patients with HBV-related HCC who underwent surgical resection or radiofrequency ablation between 2013 and 2018 were enrolled in this retrospective cohort study. Patients were categorized into two groups according to HBV replication activity at the curative treatment of HBV-related HCC (group 1: patients who met the AVT indication for HBV-related HCC due to detectable HBV DNA but did not meet the AVT indication if without HCC; group 2: patients who met the AVT indication, regardless of HCC).

Results
In the entire cohort (n = 911), HCC recurred in 303 (33.3%) patients during a median follow-up of 4.7 years. After multivariate adjustment, group 2 showed a statistically similar risk of HCC recurrence (adjusted hazard ratio [aHR] = 1.18, P = 0.332) compared to that of group 1. In addition, group 2 showed statistically similar risks of early (< 2 years; aHR = 1.31) and late (≥ 2 years; aHR = 0.83) recurrence than that of group 1 (all P>0.05). Propensity score matching and inverse probability of treatment weighting analysis also yielded similar risks of HCC recurrence between the two groups (all P>0.05, log-rank tests).

Conclusions
The risk of HCC recurrence in patients who received curative treatment for newly diagnosed HBV-related HCC was similar regardless of HBV replication activity, if AVT was properly initiated.
Identifying and prioritizing recommendations to optimize transitions across the care journey for hip fractures: Results from a mixed-methods concept mapping study
Authors: Guilcher Sara J. T. , Cadel Lauren , Everall Amanda C. , Bronskill Susan E. , Wodchis Walter P. , Thavorn Kednapa , Kuluski Kerry 
Published: August 2024

Background
Individuals who experience a hip fracture have numerous care transitions. Improving the transition process is important for ensuring quality care; however, little is known about the priorities of different key interest groups. Our aim was to gather recommendations from these groups regarding care transitions for hip fracture.

Methods
We conducted a concept mapping study, inviting persons with lived experience (PWLE) who had a hip fracture, care partners, healthcare providers, and decision-makers to share their thoughts about ‘what is needed to improve care transitions for hip fracture’. Individuals were subsequently asked to sort the generated statements into conceptual piles, and then rate by importance and priority using a five-point scale. Participants decided on the final map, rearranged statements, and assigned a name to each conceptual cluster.

Results
A total of 35 participants took part in this concept mapping study, with some individuals participating in multiple steps. Participants included 22 healthcare providers, 7 care partners, 4 decision-makers, and 2 PWLE. The final map selected by participants was an 8-cluster map, with the following cluster labels: (1) access to inpatient services and supports across the care continuum (13 statements); (2) informed and collaborative discharge planning (13 statements); (3) access to transitional and outpatient services (3 statements); (4) communication, education and knowledge acquisition (9 statements); (5) support for care partners (2 statements); (6) person-centred care (13 statements); (7) physical, social, and cognitive activities and supports (13 statements); and (8) provider knowledge, skills, roles and behaviours (8 statements).

Conclusions
Our study findings highlight the importance of person-centred care, with active involvement of PWLE and their care partners throughout the care journey. Many participant statements included specific ideas related to continuity of care, and clinical knowledge and skills. This study provides insights for future interventions and quality improvement initiatives for enhancing transitions in care among hip fracture populations.
Effectiveness and safety of photobiomodulation therapy in diabetic peripheral neuropathy: Protocol for a systematic review and meta-analysis
Authors: Fan Xuechun , Yan Guanchi , Cao Jingsi , Zhao Yunyun , Wang Ying , Wang Xiuge , Mi Jia 
Published: August 2024

Introduction
Diabetic peripheral neuropathy (DPN), a widely prevalent complication in patients with type 2 diabetes, exerts a significant influence on patients’ overall health and financial circumstances. Photobiomodulation therapy is one of the means of physical therapy for DPN. Although preliminary findings suggest the efficacy of photobiomodulation therapy in alleviating peripheral neuropathy, the existing literature lacks substantial evidence regarding its safety and effectiveness specifically in the context of diabetes-related peripheral neuropathy. Therefore, we plan to arrive at more distinct findings through systematic evaluation and meta-analysis.

Methods
We will conduct a comprehensive search for studies published from the beginning until October 1, 2023, using various databases including Web of Science, Embase, Cochrane Library, PubMed, AMED, Wanfang database, VIP database, China National Knowledge Infrastructure, and the Chinese Biomedical Literature database. Simultaneously, we will also search for the WHO International Clinical Trial Registration Platform, China Clinical Trial Registration Platform, and Clinical Trials.gov. Gray literature will be retrieved using Google Scholar and opengrey.edu. Only randomized controlled trials in Chinese and English were included, with no restrictions on publication status. The primary outcomes will include change of symptom scores, change of nerve conduction velocity. Additional outcomes will encompass quality of life, change in pain, blood glucose levels after fasting and 2 hours after eating, levels of glycosylated hemoglobin, and any adverse events associated with photobiomodulation therapy. Reman V.5.4 and R language will be used for the meta-analysis. Assessment of potential bias will be conducted through Cochrane risk of bias 2 tool (RoB 2.0) and Physiotherapy Evidence Database (PEDro) scale. Registration: PROSPERO (registration number: CRD42023466586).

Discussion
This meta-analysis aims to assess the efficacy and safety of photobiomodulation therapy as a potential treatment for diabetic peripheral neuropathy (DPN), and providing a straightforward and convenient therapeutic for patients. Additionally, it expands the range of treatment alternatives available to healthcare professionals managing DPN.
Mobile game addiction and its association with musculoskeletal pain among students: A cross-sectional study
Authors: Ahmed Sohel , Samuel Asir John , Mishra Arushi , Rahman Md Saifur , Islam Md. Ariful , Rashaduzzaman Md. , Roy Shankar Kumar , Akter Rahemun , Islam Mohammad Jahirul 
Published: August 2024

Background
The purpose of this study was to ascertain whether there is a difference in musculoskeletal pain between those who are addicted to mobile games and those who are not, to ascertain the association between mobile game addiction and socio-demographic variables, and to ascertain the pain predictor for mobile game addiction on different musculoskeletal regions.

Methods
There were 840 students in all, both males and females, in this cross-sectional survey from three distinct Bangladeshi institutions. The Nordic Musculoskeletal Discomfort Questionnaire, the Gaming Addiction Scale, and the demographic data form were distributed to the participants. The data were analyzed using the Chi-square test and descriptive statistics. Binary logistic regression was used to find the predicted risk factor for mobile gaming addiction.

Results
Musculoskeletal pain affects 52.1% of participants in some part of the body. Males have a 2.01-fold higher likelihood of developing gaming addiction compared to females. Those who are addicted to mobile games experience a higher occurrence of pain in the neck, upper back, elbows, and wrist and hands with a odds ratio of (OR 2.84, 95% CI: 1.49–5.36; p = 0.016), (OR 3.75, 95% CI 1.97–7.12; p = <0.001), (OR 3.38, 95% CI 1.34–8.50; p = 0.010), and (OR 2.14, 95% CI 1.00–4.57; p = 0.049) respectively.

Conclusion
These results demonstrate that mobile gaming addiction raises students’ risk of musculoskeletal discomfort. Two-three times higher risk of developing pain in the neck, upper back, elbows, and wrist and hands among mobile game addicts.
Association between skin autofluorescence and coronary calcification in the general population
Authors: Boersma Henderikus E. , Xia Congying , van der Klauw Melanie M. , Vonder Marleen , Oudkerk Matthijs , van der Harst Pim , Jan Pelgrim Gert , Wolffenbuttel Bruce H. R. , Smit Andries J. , Vliegenthart Rozemarijn 
Published: August 2024

Objective
To address the relationship between tissue accumulation of advanced glycation end-products, assessed by skin autofluorescence (SAF), and subclinical atherosclerosis quantified with coronary artery calcium score (CACS) in the general Dutch population.

Methods
A total of 3,839 participants of the LifeLines Cohort Study without diabetes or cardiovascular disease were included in this cross-sectional evaluation. They underwent SAF measurement and cardiac computed tomography to measure CACS. Associations between SAF and CACS was assessed using regression models. Participants at elevated risk for cardiovascular disease were selected by either CACS≥100, or SAF value in the top 15%; overlap and cardiovascular risk profile of these participants were compared.

Results
In univariate analysis, every 1 arbitrary unit (AU) increase in SAF resulted in an odds ratio of 2.91 (95% confidence interval 2.44–3.48, p<0.001) for coronary calcification. After adjustment for cardiovascular risk factors, there was still 20% higher odds of coronary calcification with 1 AU increase in SAF, but significance was lost. In total, 1025 (27%) participants either had high SAF and/or high CACS, of these 441 (12%) had only high SAF, 450 (12%) had only high CACS and 134 (3%) participants had high SAF and high CACS.

Conclusion
In a population-based Dutch cohort, SAF was associated with the degree of coronary calcification. This association was largely explained by classical cardiovascular risk factors. Limited overlap was found in subgroups with high SAF or high CACS, indicating that SAF and CACS may have complementary role in identifying individuals at elevated cardiovascular risk.
Emergence and expansion of carbapenem resistant enterobacterales in the Western Cape Province, South Africa
Authors: Moloto Kedišaletše , Newton-Foot Mae , Whitelaw Andrew , Dramowski Angela 
Published: August 2024

Background
Carbapenem resistant Enterobacterales (CRE) have become established as leading pathogens in South African healthcare facilities. The aim of this study is to describe the epidemiology of CRE carriage and clinical infection episodes at healthcare facilities in the Western Cape Province of South Africa (2016–2020), and identify factors associated with mortality in CRE infected patients.

Methodology
We used routine data from the Provincial Health Data Centre to track the emergence of CRE in healthcare facilities in the Western Cape Province of South Africa. We included all CRE episodes (clinical and carriage) at Western Cape hospitals (including day and inpatients) from 2016 to 2020 to determine the distribution of CRE, patient demographics and antibiotic resistance phenotypes. Logistic regression was performed to identify factors associated with mortality from clinical CRE episodes.

Results
2242 CRE episodes (1580 [70.5%] clinical and 662 [29.5%] carriage) were identified. From these, 2281 CRE isolates were identified, with Klebsiella species predominating (1644, 72.1%). Affected patients had a median age of 31 (IQR 0–52) years, and 1167 (52.0%) were male. Most CRE episodes were recorded in central hospitals (70.0%, p < 0.001). Where outcome data was available, crude in-hospital mortality rates were 26.9% (371/1379) for CRE clinical episodes versus 6.4% (41/640) for CRE carriage episodes (p < 0.001). Factors that showed a statistically significant association with in-hospital mortality were female sex [adjusted odd ratio (aOR) 1.40 (95% confidence interval (CI) 1.09–1.560)], adult patients [aOR 1.76 (95% CI 1.20–2.57)], CRE isolation from a sterile specimen [aOR 0.41 (95% CI 0.32–0.53)], and >3 days between hospital admission and specimen collection [aOR 1.56 (95% CI 1.11–2.18)]

Conclusions
CRE episodes at Western Cape healthcare facilities are concentrated at tertiary hospitals, with high case fatality rates in patients with clinical CRE episodes. Infection control interventions must be strengthened to reduce transmission of CRE, and to reduce infection risks.
Prevalence and associated risk factors of current hepatitis C infection among U.S. general population and injection drug users aged 20–59 years: NHANES 2009–2018
Authors: Mazumder Harun , Hossain Md Faruk , Shrestha Pratibha , Mahmud Sultan , Husain Maidul , Ahmed Rebeka 
Published: August 2024

Introduction
The people who inject drugs (PWID) are attributed to high-risk groups for transmission of the Hepatitis C virus (HCV). This study assessed the prevalence and associated factors of current HCV infection (CHI) among U.S. general population and PWID of ages between 20 and 59 years old.

Methods
This study utilized cross-sectional data from the 2009–2018 National Health and Nutrition Examination Survey, conducting separate analyses for the U.S. general population, including PWID and non-PWID, as well as specific analyses focusing solely on PWID. The analytical methods included the estimation of CHI prevalence, Rao-Scott chi-square test to compare CHI-positive and CHI-negative groups, and univariate and multivariable logistic regressions models to evaluate the associated risk factors of CHI.

Results
The prevalence of CHI among general population and PWID were 1% and 19%, respectively. Compared to non-PWID, the odds of CHI were significantly higher among PWID (OR = 32.6, 95% CI = 17.7–60.3) in general population. Among PWID, male vs. female (OR = 2.6, 95% CI = 1.1–5.9), adults aged 40–59 vs. 20–39 years old (OR = 2.9, 95% CI = 1.2–7.3), Non-Hispanic Black vs. White (OR = 4.6, 95% CI = 1.5–13.6), with high school diploma or less educational attainment vs. above college degree (OR = 3.5, 95% CI = 1.4–9.2) showed higher odds of having CHI.

Conclusion
The prevalence of CHI was found to be higher among PWID especially those who were male, aged 40–59 years old, Non-Hispanic Black, and had lower educational attainment. Targeted intervention such as screening and awareness program among PWID population is recommended to reduce the burden of new HCV infections in the U.S.
An approach to integrated management of diabetes in tuberculosis patients: Availability and readiness of the health facilities of Bangladesh
Authors: Rafi Md. Abdur , Semanta Senjuti , Shahriar Tasnim , Hasan Mohammad Jahid , Hossain Md. Golam 
Published: August 2024

Background
Comorbidity of diabetes mellitus and tuberculosis (TB) is a major public health concern in low- and middle-income countries including Bangladesh. An integrated approach is required for adequate management of diabetes mellitus and TB. The objective of the present study was to investigate the availability and readiness of the TB care centers of Bangladesh toward diabetic patients’ management.

Methods
The present study was conducted based on existing data obtained from the Bangladesh Health Facility Survey (BHFS) 2017. Data collected from a total of 303 facilities providing TB services were retrieved. The outcome variables of the present study were availability and readiness of the TB health facilities for providing diabetes mellitus service. Readiness was measured for four domains: staff and guidelines, equipment, diagnostic facility and basic medicine. The independent variables were: facility level, management authority and location of the facility. Binary and multiple logistic regression models were constructed for both the outcome variables (availability and readiness) to find out their predictors.

Results
Services for diabetes mellitus were available in 68% of the TB facilities while high readiness was present in 36% of the facilities. For domain-specific readiness index, readiness for the domains of staff and guidelines, equipment, diagnostic facility and basic medicine was reported in 46%, 96%, 38% and 25% facilities respectively. In the logistic regression model, availability of diabetes mellitus services was better in primary level (aOR 2.62, 95% CI 1.78–4.77) and secondary level (aOR 3.26, 95% CI 1.82–9.05) facilities than community facilities. Similarly, readiness of diabetes mellitus care was also better in these facilities (aOR 2.55, 95% CI 1.05–4.71 for primary and aOR 2.75, 95% CI 1.80–4.32 for secondary facilities). Besides, private TB facilities had better availability (aOR 2.84, 95% CI 1.75–5.89) and readiness (aOR 2.52, 95% CI 1.32–4.29) for diabetes mellitus care.

Conclusion
Availability and readiness for providing diabetes mellitus services in TB care providing facilities in Bangladesh is inadequate.