bluuebunny/crossref_metadata_2025_split huggingface dataset:
A standardised FACS assay based on native, receptor transfected cells for the clinical diagnosis and monitoring of β1-adrenergic receptor autoantibodies in human heart disease
Authors: Bornholz Beatrice , Benninghaus Thomas , Reinke Yvonne , Felix Stephan B. , Roggenbuck Dirk , Jahns-Boivin Valérie , Jahns Roland , Boege Fritz 
Published: September 2015

Abstract

Background: Autoantibodies against β1-adrenergic receptors (β1AR) that stimulate cardiac cAMP-production play a causal role in the pathogenesis of human heart failure. Patients can be subjected to specific therapies, if the presence of potentially cardio-noxious β1AR-autoantibodies is reliably diagnosed. This requires assessment of IgG-interactions with the native β1AR because β1AR-autoantibodies target a conformational epitope inadequately presented by denatured receptors or linear peptides. Here, we report on a standardised diagnostic procedure for the assessment of β1AR-autoantibodies in heart failure patients, which is based on IgG-binding to native human β1AR.

Methods: Good laboratory practice (GLP)-conform measurement of β1AR-autoantibodies was based on flow-cytometric quantification of differential IgG-binding to native HT1080 cells overexpressing biofluorescent human β1AR or not. Receptor-specific IgG-binding was derived from IgG-related median fluorescence of β1AR-positive cells corrected for background staining of β1AR-negative cells admixed to each measurement. The slope of IgG binding at two different concentrations was used as measure for the titre/avidity of β1AR-autoantibodies.

Results: Sensitivity and specificity of the novel procedure for high β1AR-autoantibody levels in dilated cardiomyopathy patients (n=40, NYHA class III-IV) relative to n=40 matched healthy subjects was >90%. It was similar to functional assays considered the gold standard and vastly superior to existing screening-procedures employing fixed cells or linear receptor-peptides as auto-antigenic targets. Inter-assay scatter was 7%–15% and linear dilution recovery was within ±10% of expected values throughout.

Conclusions: The novel assay possibly provides a tool to determine true prevalence and clinical impact of β1AR-autoantibodies. Furthermore, it may serve as companion diagnostic for therapies specifically directed at β1AR-autoantibodies.
Analysis of hot-wire measurements accuracy in turbulent boundary layer
Authors: Drózdz Artur , Elsner Witold 
Published: September 2015

AbstractThis paper discusses the issue of measuring velocity fluctuations of turbulent boundary layer using hot-wire probes. The study highlights the problem of spatial resolution, which is essential when measuring small-scales in wall-bounded flows. Additionally, attention was paid to the inconsistency in streamwise fluctuation measurements using single- and X-wire probes. To clarify this problem, the energy spectra using wavelet transformation were calculated. The analysis was performed for turbulent boundary layer flow, which was characterized by Reynolds number based on the friction velocity equal Re
Experimental and numerical study on condensation in transonic steam flow
Authors: Majkut Mirosław , Dykas Sławomir , Strozik Michał , Smołka Krystian 
Published: September 2015

Abstract
The present paper describes an experimental and numerical study of steam condensing flow in a linear cascade of turbine stator blades. The experimental research was performed on the facility of a small scale steam power plant located at Silesian University of Technology in Gliwice, Poland. The test rig of the facility allows us to perform the tests of steam transonic flows for the conditions corresponding to these which prevail in the low-pressure (LP) condensing steam turbine stages. The experimental data of steam condensing flow through the blade-to- blade stator channel were compared with numerical results obtained using the in-house CFD numerical code TraCoFlow. Obtained results confirmed a good quality of the performed experiment and numerical calculations.
Oil-free bearing development for high-speed turbomachinery in distributed energy systems – dynamic and environmental evaluation
Authors: Tkacz Eliza , Kozanecka Dorota , Kozanecki Zbigniew , Łagodziński Jakub 
Published: September 2015

AbstractModern distributed energy systems, which are used to provide an alternative to or an enhancement of traditional electric power systems, require small size highspeed rotor turbomachinery to be developed. The existing conventional oil-lubricated bearings reveal performance limits at high revolutions as far as stability and power loss of the bearing are concerned. Non-conventional, oil-free bearings lubricated with the machine working medium could be a remedy to this issue. This approach includes a correct design of the machine flow structure and an accurate selection of the bearing type. Chosen aspects of the theoretical and experimental investigations of oil-free bearings and supports; including magnetic, tilting pad, pressurized aerostatic and hydrostatic bearings as well as some applications of oil-free bearing technology for highspeed turbomachinery; are described in the paper.
Petrography and Geochemistry (Trace, Ree and Pge) of Pedda Cherlo Palle Gabbro-Diorite Pluton, Prakasam Igneous Province, Andhra Pradesh, India
Authors: Subramanyam K.S.V. , Reddy U.V.B. , Balaram V. , Roy Parijat 
Published: September 2015

Abstract
Prakasam Igneous Province (PIP) is an important geological domain in the Eastern Dharwar Craton (EDC), found in the junction zone between the EDC and Eastern Ghat Mobile Belt (EGMB). The Pedda Cherlo Palle (PCP) gabbros are massive, leucocratic-mesocractic, and show cumulus textures with minerals plagioclase, cpx, and amphiboles. Compositionally, plagioclase is a labradorite-bytownite, cpx is diopside to augite, olivines are hyalosiderites and amphiboles are magnesiohornblendes. PCP gabbros have normal SiO2, high Al2O3, moderate to high TiO2, Na2O and medium Fe2O3, so, classified as subalkaline tholeiitic gabbros. Fractionated rare earth element (REE) patterns, high abundance of large ion lithofile elements (LILE) and transitional metals coupled with light REE (LREE) relative enrichment over heavy REE (HREE) and Nb are characteristics of partial melting of depleted mantle and melts that have undergone fractional crystalisation. These partial melts are enriched in LREE and LILE, due to the addition of slab derived sediment and fluids. PCP gabbros contain low abundance (5.1 to 24.6 ng/g) of platinum group elements (PGE), and show an increase in the order Ir>Os>Pt>Ru»Pd>Rh. We propose that the subduction related intraoceanic island arc might have accreted to the southeastern margin of India to the east of Cuddapah basin in a collisional regime that took place during Ur to Rodinia amalgamations.
Fluid Inclusion Study of Quartz Xenocrysts in Mafic Dykes from Kawant Area, Chhota Udaipur District, Gujarat, India
Authors: Randive Kirtikumar , Hurai Vratislav 
Published: September 2015

Abstract
Unusual mafic dykes occur in the proximity of the Ambadongar Carbonatite Complex, Lower Narmada Valley, Gujarat, India. The dykes contain dense population of quartz xenocrysts within the basaltic matrix metasomatised by carbonate-rich fluids. Plagioclase feldspars, relict pyroxenes, chlorite, barite, rutile, magnetite, Fe-Ti oxides and glass were identified in the basaltic matrix. Quartz xenocrysts occur in various shapes and sizes and form an intricate growth pattern with carbonates. The xenocrysts are fractured and contain several types of primary and secondary, single phase and two-phase fluid inclusions. The two-phase inclusions are dominated by aqueous liquid, whereas the monophase inclusions are composed of carbonic gas and the aqueous inclusions homogenize to liquid between 226°C and 361°C. Majority of the inclusions are secondary in origin and are therefore unrelated to the crystallization of quartz. Moreover, the inclusions have mixed carbonic-aqueous compositions that inhibit their direct correlation with the crustal or mantle fluids. The composition of dilute CO2-rich fluids observed in the quartz xenocrysts appear similar to those exsolved during the final stages of evolution of the Amba Dongar carbonatites. However, the carbonates are devoid of fluid inclusions and therefore their genetic relation with the quartz xenocrysts cannot be established.
In situ gamma ray survey for geological mapping of Kmetasomatized metavolcanics at Bükkszentkereszt, Bükk Mts, Hungary
Authors: Németh Norbert , Pethõ Gábor , Zajzon Norbert 
Published: September 2015

Abstract
The Middle-Upper Triassic Bagolyhegy Metarhyolite Formation of the Bükk Mts. (Hungary) hosts silicified bodies with high potassic feldspar content formed by Kmetasomatism. The rocks underwent a multistage deformation history including syn- and postmetamorphic folding and faulting. As the outcrop area is covered by soil and debris with some exposed silicified cliffs only, and potassium content is a characteristic feature of the metasomatized rocks, geological mapping was supported by a spectral gamma ray survey with a scintillation detector of NaI(Tl) crystal. A thunderstorm felling the beech forest made the soil horizon B also accessible in several pits, providing the opportunity to make measurements on the weathered debris instead of the topsoil (horizon A). Measurements in different arrangements were designed to test the effects of measuring time, measuring geometry and soil horizon. Our results show that concentration values obtained on the debris with a 2 min measuring time can be compared with those measured on exposed rock surfaces, producing a more reliable geological map than measurements on the topsoil with randomly variable K depletion. Pit geometry effects can be eliminated by the K/(eU+eTh) ratio. This results in a more realistic K distribution map if neither U nor Th enrichments are present. The survey successfully delineated the unexposed outcrop of K-enriched rocks on the survey area.
Synthesis and antimicrobial properties of 5,5′-modified 2′,5′-dideoxyuridines
Authors: Negria Sergey D. , Karpenko Inna L. , Efremenkova Olga V. , Chizhov Alexander O. , Kochetkov Sergey N. , Alexandrova Liudmila A. 
Published: September 2015

Abstract
An effective method of synthesis of 5,5′-modified 2′,5′-dideoxyuridine derivatives is based on sequential 5′-iodination and azidation of 5-[4-(1-decyl)-1,2,3-triazol-1-yl]methyl-2′-deoxyuridine followed by 1,3-dipolar cycloaddition of the intermediate azide with an olefin under the catalysis of Cu(I) resulting in 75–85% yield of 5′-[4-substituted (1,2,3-triazol-1-yl]-5-[4-(1-decyl)-1,2,3-triazol-1-yl]methyl-2′,5′-dideoxyuridine. The compounds were shown to possess low cytotoxicity in Vero, A549 cells and Jurkat cell cultures and did not demonstrate noticeable antimicrobial activity.
Biology of germination of medicinal plant seeds. Part XIXb. Diaspores of Inula helenium L. from Asteraceae family
Authors: Bilińska Elżbieta , Buchwald Waldemar 
Published: September 2015

Summary
Morphological features of diaspores and seedlings of Inula helenium L. were described. A four-year cycle of monthly germination analysis was carried out. It was found that accessible light and various temperatures (30°C over 8 hours, 20°C over 16 hours) were optimal for the analysis of Inula helenium fruit germination ability. In these conditions, the percentage of germinated achenes was up to 90%. Diaspores stored in unheated room kept their viability even up to seven years after harvest.
Kinins and peptide receptors
Authors: Regoli Domenico , Gobeil Fernand 
Published: September 2015

Abstract
This paper is divided into two sections: the first contains the essential elements of the opening lecture presented by Pr. Regoli to the 2015 International Kinin Symposium in S. Paulo, Brazil on June 28th and the second is the celebration of Dr. Regoli’s 60 years of research on vasoactive peptides. The cardiovascular homeostasis derives from a balance of two systems, the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS). The biologically active effector entity of RAS is angiotensin receptor-1 (AT-1R), and that of KKS is bradykinin B2 receptor (B2R). The first mediates vasoconstriction, the second is the most potent and efficient vasodilator. Thanks to its complex and multi-functional mechanism of action, involving nitric oxide (NO), prostacyclin and endothelial hyperpolarizing factor (EDHF). B2R is instrumental for the supply of blood, oxygen and nutrition to tissues. KKS is present on the vascular endothelium and functions as an autacoid playing major roles in cardiovascular diseases (CVDs) and diabetes. KKS exerts a paramount role in the prevention of thrombosis and atherosclerosis. Such knowledge emphasizes the already prominent value of the ACE-inhibitors (ACEIs) for the treatment of CVDs and diabetes. Indeed, the ACEIs, thanks to their double action (block of the RAS and potentiation of the KKS) are the ideal agents for a rational treatment of these diseases.
Regulation of Insulin and Insulin-Like Activity in Malnourished Patients with Carcinoma Ventriculi Subjected to Total Gastrectomy and Personalized Nutritional Support/ Kontrola insulinske i aktivnosti slične insulinu kod neuhranjenih pacijenata sa tumorom želuca podvrgnutih totalnoj gastrektomiji i lično adaptiranoj ishrani
Authors: Nedić Olgica , Miljuš Goran , Malenković Vesna 
Published: September 2015

SummaryBackground: Insulin and insulin-like growth factor (IGF) activities are disturbed during critical illness. Time-course changes in the concentrations of insulin, IGF-I and IGFbinding proteins (IGFBPs) were monitored in this study and their correlation with interleukin (IL)-6 was assessed in patients subjected to total gastrectomy and specific nutritional regime.Methods: Patients were fed post-operatively according to the following scheme: parenteral nutrition on day 1, enteral nutrition combined with parenteral form from day 2 to 7, peroral nutrition from day 8 and full oral nutrition from day 14. Blood samples were taken periodically and the levels of IL-6, insulin, IGF-I and IGFBP-1 to -4 were determined.Results: On day 1 post-operatively, the concentration of IL- 6 reached its maximum and decreased afterwards. The concentration of insulin increased until day 3 and then started to fall. The concentration of IGF-I, already low preoperatively, continued to decrease. The concentration of IGFBP-1 peaked on day 1 post-operatively, whereas the concentration of IGFBP-3 decreased on that day. The concentration of IL-6 correlated positively with the concentration of IGFBP-1 and negatively with IGFBP-3. On day 14, the concentrations of IL-6, insulin and IGFBP-1 returned to or were close to their basal levels, whereas the concentrations of IGF-I and IGFBP-3 remained reduced.Conclusions: 14-day post-operative recovery, which included specific nutritional support, was suitable to restore insulin concentration and re-establish IGFBP-1 regulation primarily by nutrition. Very low IGF-I level on day 14 after surgery and IGFBP-3 concentration still lower than before surgery indicated that the catabolic condition was not compensated.
Evaluation of the Uniform Field Distortions Produced by a Toroidal Dielectric Body / Novērtējums Viendabīga Elektriskā Lauka Izkropļojumiem, Kurus Rada Toroīda Formas Dielektrisks Ķermenis
Authors: Krasnitsky Y. A. , Popov A. E. , Kalnacs A. 
Published: September 2015

Abstract
Distortions of the structure of a uniform electric field when a dielectric body with a toroidal shape is placed in it are considered in the quasi-static approximation. The rate of distortion is proposed to estimate through the effective permittivity of toroid determined by solving the corresponding boundary value problem. Some numerical estimates obtained using specially developed software in the language of Matlab are given.
Re-examining the Policies in the Humanitarian Aid Sector – A Call for Greater “Value Rationality”
Authors: Khan Sabithulla 
Published: September 2015

AbstractFaith-based giving in the U.S. constitutes over one-third of all charity (Giving USA, 2013). The proliferation of policy initiatives that promoted faith-based giving and giving to humanitarian aid organizations post George W Bush’s establishment of the Office of Faith-based initiatives and community Partnerships has been controversial, to say the least. But despite this, the sector has been robust. One segment of philanthropy that has been unnecessarily controversial is that of Islamic charity. With the attacks of September 11, 2001, there were a slew of legislative as well as Executive reforms that put Islamic charities under the scanner. Executive Order 13224 and the subsequent initiatives under the PATRIOT Act have reduced donations to Islamic charities, in the initial year. In this short paper, I argue that some of the restrictive measures in place – that apply to NGOs working in conflict zones – should be removed, so aid can reach the beneficiaries, so that NGOs’ offering this aid to not fear being targeted by U.S. law enforcement authorities. Given the massive refugee crisis we are witnessing, the role of Muslim NGOs in conflict zones may become crucial for long-term rehabilitation and resettlement.
Detection of Ultrasound and Photoacoustic Imaging with Fiber Bragg Gratings
Authors: Shuaiqi Jing , Jianye Sun , Nengzhu Zhang , Lin Huang , Jian Rong 
Published: September 2015

AbstractIn this paper, we explore a simple and effective fiber Bragg grating demodulation setup to detect ultrasound. Different frequency ultrasound from hundreds of kHz to several MHz were detected successfully. For the first time, we combine ultrasound from a PZT transducer with a photoacoustic imaging systemto obtain a clear photoacoustic image of our pencil lead sample. With the advantage of small size and all-optical features, this method has the potential to be applied to medical endoscopic examination in an electromagnetic environment. This preliminary study suggests that the ultrasound detection with fiber Bragg grating is both meaningful and feasible.
Thermoacoustic imaging of human finger joints and bones
Authors: Lin Huang , Weizhi Qi , Yuan Zhao , Zihui Chi , Nengzhu Zhang , Jian Rong , Dakun Lai 
Published: September 2015

AbstractIn this study, we explore a new application of thermoacoustic tomography (TAT) for imaging human finger joints and bones. Three volunteers’ finger joints and bones were visualized with satisfying image contrast and spatial resolution by a TAT scanner. The recovered TAT images revealed apparent microwave absorption differences between the joint cavity and bone. Beyond the full single finger imaging, a volunteer’s four fingers were clearly and concurrently imaged. To confirm our observations, MRI images of two volunteers’ fingers were performed, and the TAT recovered shape/size of the fingers were consistent with the MRI findings. To further assess the feasibility of TAT for finger joint and bone imaging, we quantitatively calculated the conductivity of a case. This initial study suggests that TAT may be a good candidate for screening, diagnosing, and monitoring treatment of joint and bone diseases.
Thermoacoustic tomography: A novel method for early breast tumor detection
Authors: Lin Huang , Weizhi Qi , Jinyu Xu , Yuan Zhao , Zihui Chi , Dan Wu , Jian Rong , Dakun Lai 
Published: September 2015

AbstractThis article presents a comprehensive review on a non-invasive, high resolution and high contrast imaging modality, called thermoacoustic tomography (TAT). Details about the principles, history and future directions of TAT are described.
Magnetoacoustic Tomography with Magnetic Induction (MAT-MI) Reconstruction Algorithm Based on Characteristics of Acoustic Transducer
Authors: Ma Ren , Yin Tao , Liu Zhipeng 
Published: September 2015

AbstractA MAT-MI reconstruction algorithm was applied to general sound detection systems, and the influence of acoustic transducers on MAT-MI image reconstruction was investigated in this paper. The acoustic intensity measurement system was used to measure the acoustic field, and the data was then used to build the acoustic transducer model by a interpolation method. The model was applied to forward and inverse problems of MAT-MI based on Green’s function and discretization method. In order to verify the algorithm, a simulation was carried out using sphere scan schema and cylinder scan schema. A 3D phantom model was set up based on S-L model in CT, with the help of finite element analysis method and the distribution of the transient electromagnetic field and the eddy currentwere calculated. Simulation and reconstruction results through numerical calculation using MATLAB were obtained. Results show that the algorithm can reconstruct the distribution of acoustic source vector; the correlation coefficients are 98.49% and 94.96%, and can be applied to the general transducer. This study provided a basis for the experimental study of MAT-MI and a precise reconstruction of conductivity distribution.
Recent Progress in Multimodal Photoacoustic Tomography
Authors: Xia Jun , Wang Yuehang , Wan Hongying 
Published: September 2015

AbstractSince its first demonstration of functional imaging in small animals about a decade ago, photoacoustic tomography (PAT) has quickly become one of the fastest growing biomedical imaging modalities. Combining optical excitation with acoustic detection, PAT can provide detailed images of tissues deep in the body. While PAT technology continues to improve significantly, substantial efforts have also been made to develop multimodal PAT systems. These systems not only provide complementary information for more comprehensive characterization of tissue, they also generate data that can be used to further improve PAT reconstruction. This review will present current progress in multimodal PAT imaging, focusing on the technical aspects of integration and its applications in biomedicine.
First record of the Austral Negrito (Aves: Passeriformes) from the South Shetlands, Antarctica
Authors: Gryz Piotr , Korczak−Abshire Małgorzata , Gerlée Alina 
Published: September 2015

AbstractThe order Passeriformes is the most successful group of birds on Earth, however, its representatives are rare visitors beyond the Polar Front zone. Here we report a photo-documented record of an Austral Negrito (Lessonia rufa), first known occurrence of this species in the South Shetland Islands and only the second such an observation in the Antarctic region. This record was made at Lions Rump, King George Island, part of the Antarctic Specially Protected Area No. 151 (ASPA 151). There is no direct evidence of how the individual arrived at Lions Rump, but ship assistance cannot be excluded.
The Impact of Nutrition, Sedentary Behaviour and Lifestyle on School-Age Children
Authors: Pantea-Stoian Anca , Chilianu Sabina , Stefanca Florentina , Elian Viviana , Serafinceanu Cristian 
Published: September 2015

Abstract
Background and Aims. Diet and lifestyle in school-age children have a particularly large impact on health, as well as various consequences in future. The objective of this papers it to assess the relationship between lifestyle and daily diet and the effects of an unhealthy diet. Material and Methods. An observational cohort study was conducted in Bucharest, in three schools and one high school on 100 children, between 2011 and 2013. The criterion for inclusion was the appropriate age (school-age). The protocol consisted in clinical examination, body mass index (BMI) calculation, questions about diet, physical activity and time spent watching television (TV). Results. Most children do not respect a schedule of meals and snacks (78%). Unhealthy diet (fast food, carbonated beverages, chocolate) registered higher preferences. Mean TV time was 2.32 hours/day (SD=1.92) and a strong evidence on relationship between age and number of hours allocated to TV was discovered (p< .01). Four percent of children were found to be under the 5th percentile (underweight), 18% between 85th and 95th percentile (overweight) and 14% above 95th percentile (obesity). Conclusions. A sedentary life in this case was mainly determined by the time spent daily in front of the television rather than lack of exercise.