bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring decision confidence
Authors: Arts Sara , Ong Qiyan , Qiu Jianying 
Published: July 2024

AbstractWe examine whether the way individuals randomize between options captures their decision confidence. In two experiments in which subjects faced pairs of options (a lottery and a varying sure payment), we allowed subjects to choose randomization probabilities according to which they would receive each option. Separately, we obtained two measures of self-reported confidence - confidence statements and probabilistic confidence - for choosing between the two options. Consistent with the predictions of two theoretical frameworks incorporating preference uncertainty, the randomization probabilities correlated strongly with both self-reported measures (median Spearman correlations between 0.86 to 0.89) and corresponded in absolute levels to probabilistic confidence. This relationship is robust to two exogenous manipulations of decision confidence, where we varied the complexity of the lottery and subjects’ experience with the lottery.
A Systematic Review of Artificial Intelligence Models for Time-to-Event Outcome Applied in Cardiovascular Disease Risk Prediction
Authors: Teshale Achamyeleh Birhanu , Htun Htet Lin , Vered Mor , Owen Alice J. , Freak-Poli Rosanne 
Published: July 2024

Abstract
Artificial intelligence (AI) based predictive models for early detection of cardiovascular disease (CVD) risk are increasingly being utilised. However, AI based risk prediction models that account for right-censored data have been overlooked. This systematic review (PROSPERO protocol CRD42023492655) includes 33 studies that utilised machine learning (ML) and deep learning (DL) models for survival outcome in CVD prediction. We provided details on the employed ML and DL models, eXplainable AI (XAI) techniques, and type of included variables, with a focus on social determinants of health (SDoH) and gender-stratification. Approximately half of the studies were published in 2023 with the majority from the United States. Random Survival Forest (RSF), Survival Gradient Boosting models, and Penalised Cox models were the most frequently employed ML models. DeepSurv was the most frequently employed DL model. DL models were better at predicting CVD outcomes than ML models. Permutation-based feature importance and Shapley values were the most utilised XAI methods for explaining AI models. Moreover, only one in five studies performed gender-stratification analysis and very few incorporate the wide range of SDoH factors in their prediction model. In conclusion, the evidence indicates that RSF and DeepSurv models are currently the optimal models for predicting CVD outcomes. This study also highlights the better predictive ability of DL survival models, compared to ML models. Future research should ensure the appropriate interpretation of AI models, accounting for SDoH, and gender stratification, as gender plays a significant role in CVD occurrence.
Evaluation of two CaMn1−x−yTixFeyO3−δ-based granules oxygen carriers for chemical looping applications
Authors: Li Zuoan , Gaertner Heiko , Sunding Martin F. , Larring Yngve 
Published: July 2024

AbstractUpscaling of the laboratory oxygen carriers while keeping comparable performance as laboratory powders remains a challenge in the field of chemical looping combustion (CLC). In this work, two perovskite compositions of CaMn0.375Ti0.5Fe0.125O3 (termed CMTF8341) and CaMn0.5Ti0.375Fe0.125O3 (CMTF8431) have been fabricated by means of spray granulation. The fabricated granules were evaluated by redox cycles under CLC conditions and showed comparable performance with laboratory-prepared powders, i.e. high oxygen transfer capacity and fast redox kinetics. Under chemical looping oxygen uncoupling (CLOU) conditions, it has been found that steam leads to a slower kinetics and lower oxygen transfer capacity for these two compositions. When it comes to sulphur effect on the oxygen carriers, redox cycles with deep reduction showed no influence with H2S since the CaSO4 formed in air decompose but it affected the materials under mild CLOU due to calcium sulphate formed under such condition. Nonetheless, redox performance can be recovered by deep reduction with an enhanced oxygen capacity. These two oxygen carriers showed no degradation as compared to other tested minerals in the field of CLC. Microstructure analyses from SEM showed high degree of structure integrity after redox cycles at temperatures up to 1050 °C for the CMTF8341. Good mechanical strength was evidenced from cold attrition test, and the lifetime of the two granules was also predicted based on a standard reference.
Parameterization of nonlinear aeroelastic reduced order models via direct interpolation of Taylor partial derivatives
Authors: Candon Michael , Hale Errol , Balajewicz Maciej , Delgado-Gutiérrez Arturo , Muscarello Vincenzo , Marzocca Pier 
Published: July 2024

AbstractThe identification of optimally sparse Taylor partial derivatives presents a new opportunity in efficient nonlinear model reduction for complex aeroelastic systems. Unfortunately, for this class of reduced order model (ROM), the robustness that is observed in the linear regime to parameters including; dynamic pressure, control hinge linear stiffness, or even freeplay, can be quickly compromised in the nonlinear regime. In this paper, the nonlinear sensitivity of selected critical parameters is addressed by interpolating a library of nonlinear unsteady aerodynamic ROMs across a compact subspace in dynamic pressure and freeplay magnitude. The ROM, based on Lagrange interpolation of sparse higher-order Taylor partial derivatives, demonstrates excellent precision in modelling high amplitude transonic limit cycle oscillations for an all-movable wing with freeplay, capturing the LCO region (up to 96% of the linear flutter boundary), and for a range of freeplay values.
What is an art experience like from the viewpoint of sculpting clay?
Authors: March Paul Louis 
Published: July 2024

Abstract
For enactivists and pragmatists alike, sense-making is a systemic process of bringing the organism and environment into reciprocity. Steiner (2023) distinguishes enactivism from pragmatism by arguing that intention is compatible with enactivism but not pragmatism. After reviewing Steiner’s analysis, I consider its ontological consequences and phenomenological implications which I suggest cause problems for both enactivism and pragmatism, but in two different ways. Intention is consistent with the idea of an autonomy of sense-making but reveals its latent subjectivity – which sits uncomfortably with an enactivist account. The absence of intention implies the existence of states of supra-subjective consciousness but lack of such accounts is troublesome for pragmatism. Next, I introduce Material Engagement Theory. I emphasise its affinity to pragmatism and describe its role in developing clayful phenomenology, an experiential way of investigating creative practice from the perspective of the process. A case-study of a sculptural project illustrates how action, creating a construction-site atmosphere as it goes, gathers diverse materials and elements to itself: wood, clay, plaster, steel, a sculpted skull, a painting, a wall, tree trunks, scaffolding, neolithic sculptures etc. These elements draw themselves into rhythmical associations that resonate with others that are formed through and by sculptural gestures and these go onto form further gestural patterns. The project shows how a creative situation creates a sense of affective purpose by and through the act of creating itself.
Assessing earthworm exposure to a multi-pharmaceutical mixture in soil: unveiling insights through LC–MS and MALDI-MS analyses, and impact of biochar on pharmaceutical bioavailability
Authors: Fučík Jan , Jarošová Rea , Baumeister Andreas , Rexroth Sascha , Navrkalová Jitka , Sedlář Marian , Gargošová Helena Zlámalová , Mravcová Ludmila 
Published: July 2024

AbstractIn the European circular economy, agricultural practices introduce pharmaceutical (PhAC) residues into the terrestrial environment, posing a potential risk to earthworms. This study aimed to assess earthworm bioaccumulation factors (BAFs), the ecotoxicological effects of PhACs, the impact of biochar on PhAC bioavailability to earthworms, and their persistence in soil and investigate earthworm uptake mechanisms along with the spatial distribution of PhACs. Therefore, earthworms were exposed to contaminated soil for 21 days. The results revealed that BAFs ranged from 0.0216 to 0.329, with no significant ecotoxicological effects on earthworm weight or mortality (p > 0.05). Biochar significantly influenced the uptake of 14 PhACs on the first day (p < 0.05), with diminishing effects over time, and affected significantly the soil-degradation kinetics of 16 PhACs. Moreover, MALDI-MS analysis revealed that PhAC uptake occurs through both the dermal and oral pathways, as pharmaceuticals were distributed throughout the entire earthworm tissue without specific localization. In conclusion, this study suggests ineffective PhAC accumulation in earthworms, highlights the influence of biochar on PhAC degradation rates in soil, and suggests that uptake can occur through both earthworm skin and oral ingestion.
Graphical Abstract
Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant
Authors: Traa Annika , Tamez González Aura A. , Van Raamsdonk Jeremy M. 
Published: July 2024

AbstractThe dynamic nature of the mitochondrial network is regulated by mitochondrial fission and fusion, allowing for re-organization of mitochondria to adapt to the cell’s ever-changing needs. As organisms age, mitochondrial fission and fusion become dysregulated and mitochondrial networks become increasingly fragmented. Modulation of mitochondrial dynamics has been shown to affect longevity in fungi, yeast, Drosophila and C. elegans. Disruption of the mitochondrial fission gene drp-1 drastically increases the already long lifespan of daf-2 insulin/IGF-1 signaling (IIS) mutants. In this work, we determined the conditions required for drp-1 disruption to extend daf-2 longevity and explored the molecular mechanisms involved. We found that knockdown of drp-1 during development is sufficient to extend daf-2 lifespan, while tissue-specific knockdown of drp-1 in neurons, intestine or muscle failed to increase daf-2 longevity. Disruption of other genes involved in mitochondrial fission also increased daf-2 lifespan as did treatment with RNA interference clones that decrease mitochondrial fragmentation. In exploring potential mechanisms involved, we found that deletion of drp-1 increases resistance to chronic stresses. In addition, we found that disruption of drp-1 increased mitochondrial and peroxisomal connectedness in daf-2 worms, increased oxidative phosphorylation and ATP levels, and increased mitophagy in daf-2 worms, but did not affect their ROS levels, food consumption or mitochondrial membrane potential. Disruption of mitophagy through RNA interference targeting pink-1 decreased the lifespan of daf-2;drp-1 worms suggesting that increased mitophagy contributes to their extended lifespan. Overall, this work defined the conditions under which drp-1 disruption increases daf-2 lifespan and has identified multiple changes in daf-2;drp-1 mutants that may contribute to their lifespan extension.
Association between adult education, brain volume and dementia risk: longitudinal cohort study of UK Biobank participants
Authors: Jin Jiayin , Sommerlad Andrew , Mukadam Naaheed 
Published: July 2024

AbstractLess childhood education is a potentially modifiable risk factor for developing incident dementia but it is not known if education in later life is protective. We sought to add to previous work by testing the association between adult education and brain volume as well as exploring the impact of continuing adult education versus intermittent participation. We used data from participants of the UK Biobank cohort, with no prevalent dementia who were asked about adult education participation at baseline and at follow-up. Dementia status was ascertained from self-report or electronic health records. Cox proportional hazards models were built to estimate hazard ratios (HRs) between participation in adult education and dementia risk. In 499,337 participants aged between 40 and 69 at baseline with 13.2 years mean follow-up, in analyses adjusted for age, sex, education, deprivation, ethnicity, hypertension, diabetes, ethnicity, obesity, smoking, alcohol use, physical inactivity and social isolation, we replicated previous findings of a protective effect of adult education on dementia risk (HR 0.82, 95% CI 0.74–0.90, P < 0.001), and showed a trend towards protection against dementia if adult education was continued rather than intermittent. Additionally, adult education did not impact on total brain volume (coefficient − 657.4, 95% CI − 2795.1 to 1480.3, P = 0.547) but it was associated with increased hippocampal volume (coefficient 33.9, 95% CI 8.9 to 59.0, P = 0.008) indicating a potential mechanism for protection against dementia. We have added evidence indicating that continuing adult education participation may be beneficial, although numbers for this analysis were very small. Analysis of brain volume indicated that adult education may have a protective effect by preserving hippocampal size or slowing volume loss, in line with the cognitive reserve hypothesis.
Hospital Rating Organizations’ Quality and Patient Safety Scores: Analysis of Result Discrepancies
Authors: Badr Samer , Nahle Tareq , Rahman Shakibur , Al Soueidy Amine , Stefaniak Martha , Burden Marisha , Rachoin Jean-Sebastien 
Published: July 2024

Abstract

Background
In the USA, multiple organizations rate hospitals based on quality and patient safety data, but few studies have analyzed and compared the rating results.

Objective
Compare the results of different US hospital-rating organizations.

Design
Observational data analysis of US acute care hospital ratings.

Participants
Four rating organizations: Hospital Compare® (HC), Healthgrades® (HG), The Leapfrog Group® (Leapfrog), and US News and World Report® (USN).

Main Measures
We analyzed the level of concordance (similar ranking), discordance (difference of 1 or more rankings), and severe discordance (difference of two or more rankings), as well as differences and correlations between the scores.

Key Results
From Feb 1 to Oct 3, 2023, we analyzed data from 2,384 hospitals. In Leapfrog, there were 688 hospitals (29%) with Grade A, 652 (27.3%) with B, 885 (37.1%) with C, 153 (6.4%) with D, and 6 (0.3%) with F. For HC, 333 hospitals (14%) had five stars, 676 (28.4%) four, 695 (29.2%) three, 502 (21.4%) two, and 171 (7.2%) one-star. In ratings between HC and Leapfrog, discordance was 70%, and severe discordance was 25.1%. USN ranked 469 hospitals (19.7%). Within the USN-ranked hospital group, there was a 62% discordance and 19.8% severe discordance between HC and Leapfrog. The analysis of orthopedic procedures from HG and USN showed discordance ranging from 48 to 61.2%.

Conclusion
The rating organizations’ reported metrics were highly discordant. A hospital's ranking by one organization frequently did not correspond to a similar ranking by another. The methodology and included timeline and patient population can help explain the differences. However, the discordant ratings may confuse patients and customers.
Bridging the nature–cultural heritage gap: evaluating sustainable entanglements through cemeteries in urban Asia
Authors: Ocón David , Young Wei Ping 
Published: July 2024

AbstractThe expanding footprint of urban Asian settlements and increasing living standards have put pressure on cemetery sites. Public health narratives and the sanctity associated with death matters in Asian urban landscapes have fed into the rhetoric of cemeteries as undesirable heritage spaces. Often lacking protection, many cemeteries have been exhumed, cleared, and relocated to allow room for new developments and infrastructure, risking the survival of this quiet element of the urban cultural patrimony. Within an Asian context, synergies between nature and cultural heritage preservation are not prevalent in major cities like Singapore, Hong Kong, Tokyo, Manila, Kuala Lumpur, and Bangkok. In light of increasing recognition of urban cemeteries as multi-valued sites with both natural and cultural heritage values, this paper turns to deconstructing the nature–cultural binary and the concept of entanglement to frame an investigation of collaborative interactions. A focused study on Asian urban cemeteries follows, examining existing trends and adapted mix uses and highlighting the region’s unique conservation challenges. The analysis reveals three major typologies encapsulating the region’s current nature–cultural heritage entangled preservation approaches: sustainable compromises, memories, and everyday sustainability. To conclude, the paper distils respectful alternative futures for these spaces to be better integrated into the modern textures of the cities, unlocking functional recourses to destruction or oblivion.
Occurrence, isolation, and identification of emergent pathogens of taxon Vibrio from the Danube river in Bratislava city, Slovakia
Authors: Vozárová Alexandra , Šmátralová Veronika , Fľaková Renáta , Seman Milan 
Published: July 2024

AbstractThe occurrence of Vibrio cholerae, Vibrio metschnikovii and Vibrio fluvialis, important aquatic human pathogens of genus Vibrio, were determined in the surface water of the Danube River in Bratislava. The isolates were identified by biochemical tests. Biochemical characteristics of environmental isolates could be slightly different from reference and clinical strains which is reflected in dissimilarity rate, which was in our case not sufficient. A molecular method called amplified ribosomal DNA restriction analysis was used for confirmation of phenotypic identification. The species identity of 19 out of 22 isolates was confirmed, in the case of 3 misidentified ones, the identity of the genus did not change. The identity of all V. cholerae isolates was confirmed by PCR using species-specific gene called ompW. Also, main virulence factors of these isolates were determined. None of the isolates possessed all three virulence factors necessary for the induction of cholera.
Trophoblast Side-Population Markers are Dysregulated in Preeclampsia and Fetal Growth Restriction
Authors: Wong Georgia P. , Hartmann Sunhild , Simmons David G. , Ellis Sarah , Nonn Olivia , Cannon Ping , Nguyen Tuong-Vi , Nguyen Anna , Bartho Lucy A. , Tong Stephen , Hannan Natalie J. , Kaitu’u-Lino Tu’uhevaha J. 
Published: July 2024

AbstractDysregulated progenitor cell populations may contribute to poor placental development and placental insufficiency pathogenesis. Side-population cells possess progenitor properties. Recent human trophoblast side-population isolation identified enrichment of 8 specific genes (CXCL8, ELL2, GATA6, HK2, HLA-DPB1, INTS6, SERPINE3 and UPP1) (Gamage et al. 2020, Stem Cell Rev Rep). We characterised these trophoblast side-population markers in human placenta and in placental insufficiency disorders: preeclampsia and fetal growth restriction (FGR). Trophoblast side-population markers localised to mononuclear trophoblasts lining the placental villous basement membrane in preterm control, preeclamptic and FGR placental sections (n = 3, panel of 3 markers/serial section). Analysis of single-cell transcriptomics of an organoid human trophoblast stem cell (hTSC) to extravillous trophoblast (EVT) differentiation model (Shannon et al. 2022, Development) identified that all side-population genes were enriched in mononuclear trophoblast and trophoblasts committed to differentiation under hTSC culture conditions. In vitro validation via 96 h time course hTSC differentiation to EVTs or syncytiotrophoblasts (n = 5) demonstrated ELL2 and HK2 increased with differentiation (p < 0.0024, p < 0.0039 respectively). CXCL8 and HLA-DPB1 were downregulated (p < 0.030, p < 0.011 respectively). GATA6 and INTS6 increased with EVT differentiation only, and UPP1 reduced with syncytialisation. SERPINE3 was undetectable. Trophoblast side-population marker mRNA was measured in human placentas (< 34-weeks’ gestation; n = 78 preeclampsia, n = 30 FGR, and n = 18 gestation-matched controls). ELL2, HK2 and CXCL8 were elevated in preeclamptic (p = 0.0006, p < 0.0001, p = 0.0335 respectively) and FGR placentas (p = 0.0065, p < 0.0001, p = 0.0001 respectively) versus controls. Placental GATA6 was reduced in pregnancies with preeclampsia and FGR (p = 0.0014, p = 0.0146 respectively). Placental INTS6 was reduced with FGR only (p < 0.0001). This study identified the localisation of a unique trophoblast subset enriched for side-population markers. Aberrant expression of some side-population markers may indicate disruptions to unique trophoblast subtypes in placental insufficiency.
Graphical Abstract
A stochastic population model with hierarchic size-structure
Authors: Barril Carles , Calsina Àngel , Farkas József Z. 
Published: July 2024

AbstractWe consider a hierarchically structured population in which the amount of resources an individual has access to is affected by individuals that are larger, and that the intake of resources by an individual only affects directly the growth rate of the individual. We formulate a deterministic model, which takes the form of a delay equation for the population birth rate. We also formulate an individual based stochastic model, and study the relationship between the two models. In particular the stationary birth rate of the deterministic model is compared to that of the quasi-stationary birth rate of the stochastic model. Since the quasi-stationary birth rate cannot be obtained explicitly, we derive a formula to approximate it. We show that the stationary birth rate of the deterministic model can be obtained as the large population limit of the quasi-stationary birth rate of the stochastic model. This relation suggests that the deterministic model is a good approximation of the stochastic model when the number of individuals is sufficiently large.
Soil Indigenous Microbes Interact with Maize Plants in High-Arsenic Soils to Limit the Translocation of Inorganic Arsenic Species to Maize Upper Tissues
Authors: Guan Hang , Caggìa Veronica , Gómez-Chamorro Andrea , Coll-Crespí Miquel , Chávez-Capilla Teresa , Schlaeppi Klaus , Ramette Alban , Mestrot Adrien , Bigalke Moritz 
Published: July 2024

Abstract
Arsenic (As) is a toxic metalloid that can enter the food chain through uptake by plants from soils followed by production of plant-based food. While soil–plant transfer of As in crops, especially rice, is relatively well studied, the role of soil microbes in As translocation in maize is not well understood. We performed a greenhouse pot experiment with maize plants grown at different soil As levels to study the role of soil microbes on uptake of different As species by maize. Three soil treatments with varying disturbance of the soil microbes (native soil, sterilized soil, and sterilized soil reconditioned with soil indigenous microbes) were intersected with three levels of As in soils (0, 100 and 200 mg kg−1 spiked As, aged for 8 weeks) in a greenhouse experiment, where maize was grown for 5 months. Compared to uncontaminated soils, maize in high-As soils tended to accumulate more As in stems and less in leaves and grains, proportionally. Arsenic levels in stems were increased in sterilized soils due to the disturbance of the microbiome. The sterilization effects caused a phosphorus and manganese deficiency, leading to a higher As uptake in plants, that increased with rising As levels and resulted in a lower total dry biomass of the plants. In summary, this study highlights the role of soil indigenous microbes in limiting the uptake and translocation of inorganic As into maize. Compared to rice, cultivating maize plants in high-As soils is recommended.