bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Anesthetic Depth Assessment During Electroconvulsive Therapy with Bispectral Index Monitoring: A Pilot Quality Improvement Project
Authors: Titch, CRNA, DNP Frank J. , Holsinger, MD Tracey , Vacchiano, CRNA, Phd Charles , Blood-Siefried, CPNP, DNSc Jane 
Published: August 2024

Background: Achieving adequate anesthetic depth during an ECT procedure without suppressing the therapeutic seizure is challenging and increases the risk of patient awareness during the procedure. Aim: To assess provider satisfaction with, and identify potential barriers to the use of BIS monitoring during ECT as a means to determine the feasibility of adopting BIS monitoring in the clinical ECT setting.Setting: The pilot project was conducted in a 274-bed general medical and tertiary care facility located on the mid-Atlantic coast that provides services to more than 200,000 patients and administers over 200 ECT treatments annually. Participants: Psychiatry staff and nurse anesthetists caring for patients undergoing ECT.Methods: A convenience sample of 11 patients scheduled for 25 ECT treatments received BIS monitoring. Provider (n= 12) satisfaction was anonymously assessed using an 8-question survey.Results: While 7 of the 12 providers rated their overall satisfaction with using the BIS monitor during ECT as Very good only 2 providers affirmatively answered the BIS monitor added value to their decision-making process.Two anesthetized patients, who responded purposefully to verbal commands despite BIS values in the deep hypnotic range indicating sufficient anesthetic depth, were considered at risk for awareness under anesthesia.Conclusions: Provider acceptance of the introduction of BIS monitoring to assess anesthetic depth during ECT was lukewarm at best. While the concept appears sound, one must question if the technology and tools are sufficiently developed to warrant its routine use in the described setting. Given the response of the two patients with BIS values indicating sufficient anesthetic depth, these observations merit further studies to replicate our findings in the psychiatric population and further explore the potential value of BIS monitoring during ECT.
A PERCEPÇÃO DOS DOCENTES DO INSTITUTO FEDERAL DE BRASÍLIA/<i>CAMPUS</i> BRASÍLIA SOBRE BEM-ESTAR NO TRABALHO
Authors: Fernandes Falcão Silvana , Furtado Rainha Silveira Flávia 
Published: August 2024

O objetivo geral desta pesquisa é realizar um diagnóstico de bem-estar no trabalho entre os professores do IFB-Campus Brasília. Como objetivos específicos pretendeu-se verificar as fontes que contribuem para o bem-estar no trabalho, apontadas pelos professores do Instituto Federal de Brasília-Campus Brasília e averiguar os aspectos negativos que interferem no bem-estar no trabalho, na percepção dos docentes da instituição. O bem-estar é conceituado como a satisfação com a vida, relacionado às emoções positivas, aos relacionamentos saudáveis, ao propósito e engajamento nas atividades. Já o bem-estar no trabalho é caracterizado como as emoções e o estado mental positivo que se forma a partir dos vínculos que o trabalhador estabelece com o trabalho e com a organização a qual faz parte. A presente pesquisa utilizou metodologia quantitativa e descritiva. O instrumento utilizado foi a Escala IBET-13 - Inventário de Bem-Estar no Trabalho, que é composto por três escalas: satisfação no trabalho (ST), envolvimento com o trabalho (ET) e comprometimento organizacional afetivo (COA). Participaram do estudo 31 professores, com idade entre 30 a 60 anos. Os dados foram analisados por meio de média simples. Os resultados apontaram nível de percepção de compromisso e satisfação no trabalho e envolvimento medianos. Conclui-se que, por apresentar esses três vínculos de maneira moderada, entende-se que faz necessário compreender as possíveis fontes de mal-estar para que se reforce a ligação dos docentes com o Instituto Federal de Brasília-Campus Brasília. Além disso, há que se fortalecer as políticas e as práticas de gestão de pessoas na organização.
PENGEMBANGAN VIDEO PEMBELAJARAN IPA MATERI HUKUM PEWARISAN SIFAT UNTUK MENINGKATKAN HASIL BELAJAR KELAS IX
Authors: Noorhilmah Noorhilmah , Sarbaini Sarbaini , Satrio Adrie 
Published: August 2024

Penelitian ini bertujuan untuk mengembangkan video pembelajaran mata pelajaran IPA materi hukum pewarisan sifat pada makhluk hidup dan mengetahui peningkatan hasil belajar peserta didik kelas IX SMP Negeri 24 Banjarmasin setelah penggunaan video pembelajaran. Metode penelitian yang digunakan adalah metode penelitian dan pengembangan dengan model pengembangan 4D yang terdiri dari tahap pendefinisian, tahap perancangan, tahap pengembangan dan tahap penyebarluasan. Teknik pengumpulan data yang digunakan yaitu wawancara, observasi, angket dan tes hasil belajar. Data yang diperoleh dianalisis menggunakan teknik analisis data deskriptif kuantitatif. Hasil uji validasi menunjukkan bahwa media video pembelajaran materi hukum pewarisan sifat pada makhluk hidup berada pada kategori sangat layak untuk digunakan dalam kegiatan pembelajaran. Hasil uji coba video pembelajaran menunjukkan bahwa video pembelajaran ini efektif untuk meningkatkan hasil belajar peserta didik kelas IX SMP Negeri 24 Banjarmasin
EVALUASI VIDEO TUTORIAL PROSES PRODUKSI MULTIMEDIA SEBAGAI SUMBER BELAJAR PESERTA DIDIK SMKN 1 AMUNTAI
Authors: Khairunnisa Khairunnisa , Mansur Hamsi , Arrum Dalu Zaudah Cyly 
Published: August 2024

Video tutorial digunakan dalam rangka menarik perhatian dan kemandirian siswa dalam memahami materi, sesuai dengan video yang dikembangkan terdapat visualisasi berupa gambar, dan materi yang dapat di mengerti oleh siswa. Tujuan penelitian ini untuk mengetahui keefektifan dan kelayakan isi, media dan desain pembelajaran. Metode penelitian yang digunakan yaitu metode kuantitatif, teknik analisis statistik deskriptif dan jenis evaluasi formatif. Subjek dari penelitian ini peserta didik kelas XII Multimedia SMKN 1 Amuntai, dan objek dari penelitian ini media pembelajaran video tutorial proses produksi multimedia. Sehingga dapat disimpulkan media video tutorial di kategorikan “Layak dan Efektif” menjadi sumber belajar pada mata pelajaran Teknik Audio Video kelas XII Smkn 1 Amuntai.
PENGEMBANGAN E-MODUL MATERI HAKIKAT BANGSA DAN NEGARA DENGAN PENDEKATAN KOGNITIF KELAS X ANIMASI SMK NEGERI 2 BANJARMASIN
Authors: Fitria Fitria , Sarbaini Sarbaini , Mastur Mastur 
Published: August 2024

Dengan adanya kemajuan teknologi saat ini menuntut inovasi dan pemanfaatan teknologi secara optimal. Modul elektronik merupakan bahan ajar digital untuk membantu pendidik dan siswa dalam berlangsungnya pembelajaran. Penelitian ini menghasilkan modul elektronik menggunakan pendekatan kognitif yang bertujuan untuk mengetahui dan menguji kelayakan dari pengembangan modul elektronik materi hakikat bangsa dan negara. Metode penelitian yang dipakai adalah metode (R&D) dengan model pengembangan 4D meliputi fase pendefinisian, perancangan, pengembangan, dan penyebarluasan. Pengumpulan data dilakukan dengan cara observasi dan angket. Uji validasi melibatkan 4 ahli yaitu 2 dari ahli materi dan 2 dari ahli media serta uji coba kepada 10 orang siswa. Teknik analisis data pada penelitian ini menggunakan analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa pengembangan modul elektronik materi hakikat bangsa dan negara dengan pendekatan kognitif ini mendapat predikat “sangat layak” dan dapat digunakan dalam pembelajaran pada mata pelajaran PPKn kelas X Animasi di SMK Negeri 2 Banjarmasin.
PEMANFAATAN APLIKASI DUOLINGO SEBAGAI MEDIA PEMBELAJARAN MANDIRI BAHASA INGGRIS
Authors: Rahmatullah Rahmatullah , Ruchliyadi Dian Agus , Sufyadi Susanti 
Published: August 2024

Bina Desa merupakan kegiatan pembinaan dan pemberdayaan masyarakat desa yang dilakukan oleh mahasiswa FKIP ULM. Pada kegiatan yang dilaksanakan di Desa Anjir Pasar Kota II ini penulis melakukan pendampingan pemanfaatan aplikasi Duolingo sebagai media pembelajaran mandiri bahasa Inggris. Tujuan penulisan laporan ini adalah menjelaskan strategi, meliputi unsur-unsur difusi inovasi yang dilaksanakan dalam kegiatan pendampingan pemanfaatan aplikasi Duolingo sebagai media pembelajaran mandiri bahasa Inggris dan menjelaskan efektivitas strategi meliputi tahapan-tahapan difusi inovasi pemanfaatan aplikasi Duolingo sebagai media pembelajaran mandiri bahasa Inggris. Metode yang digunakan pada penulisan laporan ini ditulis dengan metode deskriptif berdasarkan hasil studi fenomenologi. Metode pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi. Partisipan kegiatan ini adalah anak SD-SMA. Teknik analisis data dilakukan 3 (tiga) tahap, yaitu tahap Bracketing, tahap Horizontalization, dan tahap Cluster of Meaning. Hasil laporan ini menunjukkan bahwa aplikasi Duolingo bisa diterima anak-anak sebagai media pembelajaran mandiri bahasa Inggris setelah melalui proses putusan difusi inovasi.
ВПЛИВ ГІДРОДИНАМІЧНИХ ПРОЦЕСІВ НА ЕКОСИСТЕМИ У КОНТЕКСТІ ЕКСПЛУАТАЦІЇ ГЕС
Authors: КОЧІШ Софія , НОВИК Олена 
Published: August 2024

Ця робота розглядає гідродинамічні процеси, що відбуваються під час роботи гідроелектростанції та їхні наслідки. Було проаналізовано та оцінено вплив функціонування та конструкції ГЕС на екосистему навколишнього середовища. Виявлено, що, хоча гідроелектростанції є комерційно привабливими відновлюваними джерелами електроенергії та мають низькі викиди забруднень, гідродинамічні процеси в них сприяють евтрофікації водойми, ерозії ґрунту та знижують якість води.
Efficacy and safety of Lactobacillus plantarum GCWB1001 on respiratory health: A double-blind randomized placebo control trial
Authors: Kang Mingyu , Choi Jeong-Hee , Kim Sang-Heon , Jeong Tae Bin , Kim Joo-Young , Kim Jea-Won , Lee Chang Youl 
Published: August 2024

Abstract

Respiratory symptoms like prolonged cough and breathlessness have increased post-COVID-19, even in those with normal chest X-rays and FEV1/FVC ratios. This study assessed the benefits of Lactobacillus plantarum GCWB1001 on such symptoms in individuals without asthma or COPD. In a double-blind, randomized, placebo-controlled trial, 126 participants aged 19–70 were included. Exclusions were for asthma, COPD, abnormal chest X-rays, or recent antibiotic use. The primary outcome was BCSS, with secondary outcomes including VAS scores for respiratory function. No significant differences were found in total BCSS scores between groups. However, sputum and breathlessness improved significantly after 12 weeks of GCWB1001, especially in men and those over 40. No serious adverse events were reported, indicating safety. This study highlights the potential of GCWB1001 for managing prolonged respiratory symptoms in non-asthmatic, non-COPD individuals, meriting further research to confirm these findings.
The Liver Care Trial: Screening for liver disease in individuals attending treatment for alcohol use disorder - study protocol for a randomized controlled study
Authors: Dahlin Pernille , Jepsen Peter , Molzen Line , Madsen Lone Galmstrup , Düring Signe , Benthien Kirstine Skov , Winther-Jensen Matilde , Grew Julie Christina , Kirk Jeanette Wassar , Jensen Kristoffer Jarlov , Jensen Janne , Askgaard Gro 
Published: August 2024

Abstract

Background
Early diagnosis of alcohol-related liver disease (ALD) can improve survival if it leads to alcohol abstention or very light consumption. It is possible to screen for liver fibrosis, an asymptomatic condition of ALD that can lead to cirrhosis, by an easy and noninvasive approach called transient elastography. It has not yet been established whether screening for liver fibrosis reduces alcohol consumption among individuals with alcohol use disorders compared to usual treatment. In addition, it is important to address whether receiving a screening result indicating no ALD could lead to increased alcohol consumption (the certificate-of-health effect). This is a protocol for a study that aims to evaluate the efficacy of screening for liver fibrosis with transient elastography on alcohol use outcomes in individuals who are receiving treatment for alcohol use disorder in the community.
Methods
The study follows a randomized, controlled trial design (RCT) with concealed allocation in a 2:1 ratio to the intervention group or the control group. Blinded outcome assessments will be conducted for both parallel groups. A total of 408 patients will be randomized to receive both transient elastography and blood tests (intervention group, n = 272) or usual care consisting of a blood test (control group, n = 136). The primary outcome will be abstinence or light consumption (≤ 10 units per week, 1 unit = 12 g alcohol) throughout the last 30 days, as evaluated six months after randomization. Secondary outcomes include health-related quality of life and motivation to reduce alcohol intake. The “certificate-of-health effect” will be assessed by comparing abstinence or light alcohol consumption after six months between the screen-negative patients and the controls. Additionally, qualitative studies will explore the emotional impact of screening on participants’ and health professionals’ barriers to the implementation of screening.
Discussion
This study has the potential to offer important insights into the effect of screening for liver fibrosis on alcohol consumption among individuals who are attending treatment for alcohol use disorder. Furthermore, the study will provide insights into user and health professionals’ experiences related to screening.
Trial registration
ClinicalTrials.gov NCT05855031. Registered on the 20th of April 2023.
Executioner caspases degrade essential mediators of pathogen-host interactions to inhibit growth of intracellular Listeria monocytogenes
Authors: Walch Michael , Lavergne Marilyne , Schaerer Raffael , Bouheraoua Safaa , Adenuga Oluwadamilola , Muralt Tanja , Schaerer Tiffany , Chèvre Léa , Failla Alessandro , Matthey Patricia , Stumpe Michael , Kressler Dieter , Mantel Pierre-Yves , De Grandis Sara 
Published: August 2024

Abstract

Cell death mediated by executioner caspases is essential during organ development and for organismal homeostasis. The mechanistic role of activated executioner caspases in antibacterial defense during infections with intracellular bacteria, such as Listeria monocytogenes, remains elusive. Cell death upon intracellular bacterial infections is considered altruistic to deprive the pathogens of their protective niche. To establish infections in a human host Listeria monocytogenes deploy virulence mediators, including membranolytic listeriolysin O, allowing phagosomal escape and cell-to-cell spread. Here, by means of chemical and genetical modifications, we show that the executioner caspases-3 and − 7 efficiently inhibit growth of intracellular Listeria monocytogenes in host cells. Comprehensive proteomics revealed multiple caspase-3 substrates in the Listeria secretome, including listeriolysin O and various other proteins crucially involved in pathogen-host interactions. Listeria secreting caspase-uncleavable listeriolysin O gained significant growth advantage in epithelial cells. With that, we uncovered an underappreciated defense barrier and a non-canonical role of executioner caspases to degrade virulence mediators, thus impairing intracellular Listeria growth.
Investigations into the cellular and humoral immune mechanisms of Spodoptera litura (Fabricius) against potential entomopathogens
Authors: Thanuja Adama , Rahman S. J. , Rajanikanth P. , Bhat Bharati N. 
Published: August 2024

Abstract

Entomopathogens are foreign agents which elicits immune responses in insects. The insect innate immune system can identify and overcome these foreign-agents through cellular and humoral processes. The current study reports the cellular and humoral immune responses in Spodoptera litura to different entomopathogens including Beauveria bassiana, Metarhizium anisopliae, Bacillus thuringiensis and Nuclear Polyhedrosis virus (Sl NPV). In case of cellular immunity haemocytes are responsible for a number of defensive mechanisms in insects such as phagocytosis, nodulation, encapsulation, etc. Humoral immune responses include the recognition of invading pathogen either as bacteria, fungi or viruses followed by the immediate de novo synthesis of antimicrobial peptides (AMPs) and their secretion into the hemolymph. These peptides are mainly synthesized by the fat body and in a lesser degree by the haemocytes, integument, gut, salivary glands and reproductive structures. Third instar larvae were treated with the test entomopathogens and haemolymph was collected at different time intervals i.e., 1, 3, 6, 12, 24, 48 and 72 hours after infection (HAI) to study the cellular [Total Haemocyte Count (THC), Differential Haemocyte Count (DHC), Phagocytosis and Nodulation] and humoral (PO and Lysozyme activity) immune responses. Plasmatocytes (PLs) and Granulocytes (GRs) were observed as the main circulating haemocytes which are involved in the immune mechanism in the S. litura larvae. The immediate response of larvae to entomopathogens infection was a significant increase of total circulating hemocytes. This increase included both granulocytes and plasmatocytes. However, after 3 days from the immune challenge, the number of circulating hemocytes was significantly lower. Consequently, the larvae showed Phagocytosis, nodulation, increased PO and Lysozyme activity in the immediacy of the challenge, but progressively the phenomenon decreased.
Measuring residential PM2.5 concentrations using low-cost sensors in the Netherlands
Authors: Holtjer Judith C.S. , Houweling Laura , Downward George S. , Bloemsma Lizan D. , Zee Anke-Hilse Maitland-van der , Hoek Gerard , Vermeulen Roel C.H. 
Published: August 2024

Abstract

Accurate residential air quality assessment is crucial for studying health risks, evaluating local mitigation measures, and empowering citizens. Low-cost, easily operable sensors have gained popularity for enhancing monitoring coverage and providing individuals with air quality measurement tools. This study examines the validity of a low-cost sensor in estimating residential fine particulate matter (PM2.5) concentrations in the Netherlands. We employed a real-time Sensirion SPS30 dust sensor at a 1-minute sampling rate to monitor residential PM2.5 concentrations. 73 sensors were deployed outdoors at participants' residences for an average of 131 days each over fifteen months. Accuracy was assessed by comparing time series data from sensors with that of regulatory stations, using hourly and daily averages for comparison. Average and absolute differences were calculated for each comparison. After data cleaning, 95.7% of measurements were retained. Meteorological factors did not impact the sensor performance. The mean Pearson temporal correlation between the sensor and regulatory network was 0.75 for hourly and 0.88 for daily PM2.5 averages. The average difference ranged from -0.17 to 0.63 µg/m3, and the average absolute difference ranged from 2.42 to 4.50 µg/m3. Correlations remained consistent across various deployment conditions, including height and distance to the nearest regulatory station. This study demonstrates that PM2.5 can be accurately measured over extended periods using low-cost sensors, offering a dynamic, high-quality perspective on air quality, recording variations that regulatory stations and predictive air quality models may overlook. This demonstrates the value these sensors could have for epidemiological studies and evaluation of mitigation measures.
Water Stress is Differently Tolerated by Fusarium-Resistant and -Susceptible Chickpea Genotypes During Germination
Authors: Şimşek Ümmühan Kaşıkcı , Dikilitaş Murat , Talapov Talap , Can Canan 
Published: August 2024

Abstract

Chickpea is a legume member that grows in most parts of the world. It is negatively affected by abiotic and biotic factors like drought and fungal diseases respectively. One of the most important soil-borne pathogens affecting chickpeas is Fusarium oxysporum f.sp. ciceris. Its population dynamics in the soil is affected by fluctuation in soil water content and host. Now, drought is common in most areas of the world due to global warming. Drought stress decrease quality and quantity of the chickpeas also, particularly where soil-borne pathogens are the chief stress factor for plants. The use of both drought-tolerant and disease-resistant cultivars may be the only option for cost-effective yield production. In this study, we screened the seeds of chickpea genotypes WR-315, JG-62, C-104, JG-74, CPS-1, BG-212, ANNIGERI, CHAFFA, BG-215, UC-27, ILC-82, and K-850 for drought tolerance at increasing polyethylene glycol (PEG) concentrations (0-, 5-, 7.5-, 10-, 15-, 20-, 25-, 30- and 50%) to create drought stress conditions at different severities. The performances of genotypes that were previously tested in Foc resistance/susceptibility studies were assessed in terms of percentage of germination, radicle and hypocotyl length, germination energy, germination rate index, mean germination time, and vigor index. We determined the genotypes of C-104, CPS-1, and WR-315 as drought-susceptible, moderately drought-tolerant, and drought-tolerant, respectively. We then elucidated the stress levels of selected genotypes (8-day-old seedlings) at 0-15% PEG conditions via measuring proline and malondialdehyde (MDA) contents. Our findings showed that genotypes exhibiting drought tolerance were positively correlated with the Foc resistance and that the responses of chickpea genotypes infected with Foc under drought conditions are the next step to assess the combined stress on chickpea genotypes.
Predictive Methods for the Evolution of Oil Well Cement Strength Based on Porosity
Authors: Wen Yuhao , Chen Zi , He Yuxuan , Liu Huiting , Zhang Zhenggrong , Liu Linsong , Meng Renzhou , Zeng Yi 
Published: August 2024

Abstract

The oil well cement undergoes various physical and chemical changes during the hydration process, leading to the formation of pores of different sizes within the cement stone. These pores can affect the mechanical properties of the cement stone. In the civil engineering field, extensive attempts have been made to predict the mechanical properties of concrete based on pore parameters, yielding good results. This paper explores in detail the methods for predicting the strength of oil well cement based on porosity and pore size distribution. Through referencing the strength prediction methods for concrete in civil engineering, porosity and pore size distribution are used as prediction parameters. The accuracy of predictions made by empirical models and deep learning models is compared, and it is concluded that neither empirical formulas nor ordinary deep learning models can provide accurate fitting results. However, due to the optimization of its algorithm and structure, the KAN model can give more accurate predictions of the pore-size-strength relationship of cement stone. Additionally, the quantitative relationship between pore size and strength of cement stone is explored. The application of the KAN model in strength prediction provides strong guidance for monitoring and optimizing cementing quality during the construction process.