bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Walking on Depressive and Anxiety Symptoms: Systematic Review and Meta-Analysis
Authors: Xu Zijun , Zheng Xiaoxiang , Ding Hanyue , Zhang Dexing , Cheung Peter Man-Hin , Yang Zuyao , Tam King Wa , Zhou Weiju , Chan Dicken Cheong-Chun , Wang Wenyue , Wong Samuel Yeung-Shan 
Published: July 2024

Abstract

Background
Previous literature lacks summative information on the mental health benefits achieved from different forms of walking.

Objective
The aim of this study was to assess the effectiveness of different forms of walking in reducing symptoms of depression and anxiety.

Methods
This was a systematic review and meta-analysis of randomized controlled trials (RCTs) assessing the effects of walking on depressive and anxiety symptoms. MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, PsycINFO, Allied and Complementary Medicine Database (AMED), CINAHL, and Web of Science were searched on April 5, 2022. Two authors independently screened the studies and extracted the data. Random-effects meta-analysis was used to synthesize the data. Results were summarized as standardized mean differences (SMDs) with 95% CIs in forest plots. The risk of bias was assessed by using the Cochrane Risk of Bias tool.

Results
This review included 75 RCTs with 8636 participants; 68 studies reported depressive symptoms, 39 reported anxiety symptoms, and 32 reported both as the outcomes. One study reported the results for adolescents and was not included in the meta-analysis. The pooled results for adults indicated that walking could significantly reduce depressive symptoms (RCTs: n=44; SMD −0.591, 95% CI −0.778 to −0.403; I2=84.8%; τ2=0.3008; P<.001) and anxiety symptoms (RCTs: n=26; SMD −0.446, 95% CI −0.628 to −0.265; I2=81.1%; τ2=0.1530; P<.001) when compared with the inactive controls. Walking could significantly reduce depressive or anxiety symptoms in most subgroups, including different walking frequency, duration, location (indoor or outdoor), and format (group or individual) subgroups (all P values were <.05). Adult participants who were depressed (RCTs: n=5; SMD −1.863, 95% CI −2.764 to −0.962; I2=86.4%; τ2=0.8929) and those who were not depressed (RCTs: n=39; SMD −0.442, 95% CI −0.604 to −0.280; I2=77.5%; τ2=0.1742) could benefit from walking effects on their depressive symptoms, and participants who were depressed could benefit more (P=.002). In addition, there was no significant difference between walking and active controls in reducing depressive symptoms (RCTs: n=17; SMD −0.126, 95% CI −0.343 to 0.092; I2=58%; τ2=0.1058; P=.26) and anxiety symptoms (14 RCTs, SMD −0.053, 95% CI −0.311 to 0.206, I2=67.7%, τ2=0.1421; P=.69).

Conclusions
Various forms of walking can be effective in reducing symptoms of depression and anxiety, and the effects of walking are comparable to active controls. Walking can be adopted as an evidence-based intervention for reducing depression and anxiety. More evidence on the effect of low-intensity walking is needed in the future.
Artificial Intelligence–Augmented Clinical Decision Support Systems for Pregnancy Care: Systematic Review
Authors: Lin Xinnian , Liang Chen , Liu Jihong , Lyu Tianchu , Ghumman Nadia , Campbell Berry 
Published: July 2024

Background
Despite the emerging application of clinical decision support systems (CDSS) in pregnancy care and the proliferation of artificial intelligence (AI) over the last decade, it remains understudied regarding the role of AI in CDSS specialized for pregnancy care.

Objective
To identify and synthesize AI-augmented CDSS in pregnancy care, CDSS functionality, AI methodologies, and clinical implementation, we reported a systematic review based on empirical studies that examined AI-augmented CDSS in pregnancy care.

Methods
We retrieved studies that examined AI-augmented CDSS in pregnancy care using database queries involved with titles, abstracts, keywords, and MeSH (Medical Subject Headings) terms. Bibliographic records from their inception to 2022 were retrieved from PubMed/MEDLINE (n=206), Embase (n=101), and ACM Digital Library (n=377), followed by eligibility screening and literature review. The eligibility criteria include empirical studies that (1) developed or tested AI methods, (2) developed or tested CDSS or CDSS components, and (3) focused on pregnancy care. Data of studies used for review and appraisal include title, abstract, keywords, MeSH terms, full text, and supplements. Publications with ancillary information or overlapping outcomes were synthesized as one single study. Reviewers independently reviewed and assessed the quality of selected studies.

Results
We identified 30 distinct studies of 684 studies from their inception to 2022. Topics of clinical applications covered AI-augmented CDSS from prenatal, early pregnancy, obstetric care, and postpartum care. Topics of CDSS functions include diagnostic support, clinical prediction, therapeutics recommendation, and knowledge base.

Conclusions
Our review acknowledged recent advances in CDSS studies including early diagnosis of prenatal abnormalities, cost-effective surveillance, prenatal ultrasound support, and ontology development. To recommend future directions, we also noted key gaps from existing studies, including (1) decision support in current childbirth deliveries without using observational data from consequential fetal or maternal outcomes in future pregnancies; (2) scarcity of studies in identifying several high-profile biases from CDSS, including social determinants of health highlighted by the American College of Obstetricians and Gynecologists; and (3) chasm between internally validated CDSS models, external validity, and clinical implementation.
Implementation and Evaluation of a Home-Based Pre-Exposure Prophylaxis Monitoring Option: Protocol for a Randomized Controlled Trial
Authors: Cannon Chase , Holzhauer Katherine , Golden Matthew 
Published: July 2024

Background
HIV prevention is a public health priority. Despite progress in recent years, pre-exposure prophylaxis (PrEP) use remains suboptimal especially among groups disproportionately impacted by new HIV diagnoses such as gender and sexual minorities of color. Multiple barriers including a lack of PrEP providers and challenges with attending quarterly monitoring visits contribute to low PrEP uptake and retention. Home-based PrEP (HB-PrEP) services could reduce stigma, increase convenience, expand health system capacity for PrEP care, and improve PrEP retention.

Objective
Home Option Testing for PrEP (HOT4PrEP) is a hybrid randomized controlled trial (RCT) that aims to examine whether HB-PrEP care is acceptable to PrEP users, feasible to implement in a sexual health clinic setting, and impacts PrEP retention.

Methods
The RCT will recruit 458 persons currently taking or soon to initiate PrEP at a sexual health clinic in Seattle, Washington, and randomize them to continue the standard of care or have the option to use HB-PrEP for 2 of 3 triannual PrEP follow-up visits. Participants in the intervention arm will be sent home kits containing gonorrhea and chlamydia swabs and Tasso devices for blood self-collection. The primary outcome is PrEP retention between groups at 20 months; secondary outcomes include user satisfaction and acceptability, feasibility, self-reported PrEP adherence, and sexually transmitted infection (STI) incidence. Interviews with PrEP users and clinic staff will elucidate barriers and facilitators of implementation.

Results
The HOT4PrEP RCT began enrolling in March 2022, was on hold during the height of the US mpox epidemic, then resumed enrollment in December 2022. Of the first 100 enrollees, the median age is 34 years, and most are cisgender gay men (89/100, 89%) with at least some college education (91/100, 91%). Among the 49 participants randomized to the HB-PrEP option, 33 (67%) chose to self-collect samples at home at least once, of whom 27 (82%) successfully returned test kits for HIV and STI testing. Primary PrEP retention and qualitative analyses are ongoing.

Conclusions
Implementation of HB-PrEP into a high-volume sexual health clinic seems to be feasible and acceptable to early RCT enrollees. This strategy has the potential to address individual and systemic barriers associated with initiating and persisting on PrEP, such as increasing sexual health agency and expanding clinical capacity to serve greater numbers of PrEP users.

Trial Registration
ClinicalTrials.gov NCT05856942; https://clinicaltrials.gov/study/NCT05856942

International Registered Report Identifier (IRRID)
DERR1-10.2196/56587
Evaluating entomological measures and cypermethrin use in pest control
Authors: Susanto Agus , Kesuma Agung Puja , Zufri Armen , Putra Rizki Maisar , Wahono Tri , Astuti Endang Puji 
Published: July 2024

Purpose: This study aims to analyze entomological indicators and the susceptibility status of the Aedes aegypti mosquito to cypermethrin in the Tanjung Balai Karimun Port Health Office area.
Methods: This type of study is observational, using a cross-sectional design approach. Entomology indicator data collection is carried out routinely every month by observing containers in each building both inside and outside. The vulnerability test uses the WHO susceptibility test method.
Results: The results of entomological indicators in the perimeter area showed no density of Aedes aegypti mosquito larvae. In contrast, the density of larvae in the buffer area was low to moderate. A susceptibility test showed that 0.05% cypermethrin was still susceptible to Aedes aegypti mosquitoes.
Conclusion: These findings underscore the efficacy of the current control measures implemented in the study area and emphasize the critical need for continuous monitoring and surveillance. Maintaining such efforts is paramount for sustaining effective mosquito control initiatives and mitigating the potential risks posed by Aedes aegypti mosquitoes, thereby reducing the threat of vector-borne disease.
Calidad de Vida en Adultos Jóvenes con TDAH: Revisión Sistemática
Authors: Martínez Martínez Julieta 
Published: July 2024

El TDAH es un trastorno del neurodesarrollo que se caracteriza por un patrón perseverante de fallos atencionales, hiperactividad e impulsividad y que interfiere con el funcionamiento y desarrollo del individuo, la sintomatología va evolucionando con la edad, por lo que los síntomas que se podrían presentar en la infancia probablemente cambien. Los adultos con TDAH tienen un mayor riesgo de tener un nivel socioeconómico bajo y una disminución en logros académicos, niveles de educación y empleos funcionales, además de presentar cambios frecuentes de trabajo, mayores tasas de desempleo, comportamiento antisocial, arrestos, conflictos interpersonales y tasas más altas de divorcio y separación conyugales, lo que lleva a una baja calidad de vida, ya que sus percepciones con respecto a su posición en la vida en el contexto cultural y en relación con sus metas, expectativas, estándares y preocupaciones en las dimensiones de salud física, nivel de independencia, relaciones sociales y creencias personales se ven afectadas por las características propias de tal condición y sus comorbilidades con otras entidades psiquiátricas como depresión y ansiedad. El objetivo en esta revisión sistemática es identificar los efectos que tiene el TDAH en la calidad de vida de adultos jóvenes.
Gut Mucosal Immunity in HIV-Exposed Infants: A Review
Authors: Obeagu Emmanuel Ifeanyi , Obeagu Getrude Uzoma 
Published: July 2024

Gut mucosal immunity in infants exposed to Human Immunodeficiency Virus (HIV) presents a complex interplay of developmental processes, viral dynamics, and therapeutic interventions that significantly impact clinical outcomes. This review synthesizes current knowledge on the mechanisms, clinical implications, and therapeutic strategies concerning gut mucosal immunity in HIV-exposed infants. The gut mucosa serves as a critical site for immune maturation and defense against pathogens, but HIV infection disrupts this delicate balance, leading to compromised immune function and increased susceptibility to infections. Infants born to HIV-positive mothers experience unique challenges in gut mucosal immunity due to vertical transmission of the virus and exposure to antiretroviral therapy (ART). HIV infection disrupts gut-associated lymphoid tissue (GALT), resulting in early depletion of CD4+ T cells and compromised mucosal barrier function. These alterations contribute to microbial translocation, chronic inflammation, and immune dysregulation, impacting overall immune competence and increasing susceptibility to opportunistic infections. Despite advances in ART, persistent immune activation and residual gut mucosal damage pose ongoing challenges in achieving optimal immune reconstitution and preventing long-term complications in HIV-exposed infants. Clinical implications of compromised gut mucosal immunity in HIV-exposed infants extend beyond gastrointestinal health to encompass systemic immune dysfunction and increased risks of non-AIDS comorbidities. Impaired gut barrier function exacerbates microbial translocation, leading to systemic inflammation that may contribute to neurodevelopmental abnormalities and metabolic disorders.
Keywords: Gut, Immunity, HIV, Infants
ACESSO AOS SERVIÇOS DE SAÚDE: PERCEPÇÃO DOS PESCADORES DE UM MUNICÍPIO DO EXTREMO SUL CATARINENSE
Authors: Cardoso Carine dos Santos , Lopes Júlia de Oliveira Matos , Watanabe Melissa , Fabris Thiago 
Published: July 2024

Atenção Primária à Saúde (APS) é considerada o primeiro contato dos usuários com o Sistema Único de Saúde (SUS), e pode resolver de 80% a 90% das necessidades de saúde da população, localizada mais próxima possível do ambiente dos indivíduos e famílias. Considerando a saúde como direito constitucional à luz da saúde do trabalhador, o principal objetivo do estudo foi identificar o acesso dos pescadores Industriais aos serviços de saúde no município de Passo de Torres-SC, que tem na atividade pesqueira uma das principais fontes de renda. Utilizado como método a abordagem qualitativa, realizada em campo do tipo descritiva, aplicada com questionário semiestruturado, na colônia de pescadores, localizada no município, após a submissão e a aprovação do Comitê de Ética, sob o parecer n° 5.821.137. A análise de dado foi por categorização, apresentadas em quatro grandes categorias nos resultados e discussão nas temáticas: os serviços de saúde conhecidos pelos pescadores, acesso aos serviços de saúde, percepção dos pescadores frente sua jornada de trabalho, histórias de vida, observando no resultado que a maioria destes trabalhadores tem na APS o seu ponto de referência para acesso aos serviços. Por fim, a conclusão do estudo, pontuando as dificuldades singulares e carência de um olhar diferenciado para essa profissão, relacionam a dificuldade no acesso aos serviços de saúde com o deslocamento e a tripla jornada de trabalho. Além disso, eles destacam o amor pela profissão se sobressaindo às dificuldades encontradas e ainda referenciam a construção histórica familiar construída em décadas na atividade pesqueira.
PENGEMBANGAN MEDIA PEMBELAJARAN MACROMEDIA FLASH 8 PADA MATA PELAJARAN PERAWATAN TANGAN (MANICURE) SMK NEGERI 1 LUBUK PAKAM
Authors: Tanjung Nurhayati , Wandari Siska 
Published: July 2024

ABSTRACTThis research is a type of development research. Data Analysis of the data in this research development using quantitative descriptive analysis, all the data collected were analyzed by quantitative descriptive statistical techniques. The results of the study show that the material expert measurement gets an average percentage of 82.07% in the very good category, and the media expert measurement gets a percentage of 89.37% in the very good category. Therefore, the developed media obtained a very good category with the average score percentage (mean) from material experts and media experts of 85.72%.Keywords: Macromedia Flash 8, Learning Media ABSTRAKPenelitian yang dilakukan ini adalah jenis penelitian pengembangan. Data Analisis data dalam penelitian pengembangan ini menggunakan analisis deskriptif kuantitatif, semua data yang terkumpul dianalisis dengan teknik statistik deskriptif kuantitatif. Hasil penelitian menujukkan bahwa pengukuran ahli materi mendapatkan presentase rata-rata sebesar 82,07% dengan kategori sangat baik, dan pengukuran ahli media mendapatkan presentase sebesar 89,37% dengan kategori sangat baik. Maka dari itu, media yang dikembangkan memperoleh kategori sangat baik dengan presentase skor rata-rata (mean) dari ahli materi dan ahli media sebesar 85,72%.Kata Kunci: Macromedia Flash 8, Media Pembelajaran
Eduard Hayrapetyan Piano quartet (1981 – 1998)
Authors: Karapetyan Gohar 
Published: July 2024

As a result of the study of the theme, our conclusions are as follows:

In the present article we deal with the piano quartet of the composer Eduard Hayrapetyan. This musical work has its incomparable place both in the creative activity of the composer and in the Armenian chamber instrumental music.
Eduard Hayrapetyan is one of the prominent representatives of the Armenian composer school.
He created European classic music derived from Armenian professional musical traditions, synthesized contemporary melodic elements with folk and folk - professional elements.
He also responded with great interest to the contemporary professional musical structure and in this way created his own special composer trend.In the 20th century composer creative life was flourishing. Eduard Hayrapetyan belongs to those composers whose creative activity is appreciated by the musicians and by the listeners.
In 1981 he created the piano trio for violin, cello and piano. However some time later he transformed the trio into the piano quartet (violin, viola, cello and piano).The second part of the quartet was transformed in the figurative meaning. It became more meditative, but not in the meaning of Buddhist meditation, where human thinking is separated from reasonable notion. He described spiritual state of a human being as the heavenly spiritual world. At the same time he restrained human emotions and deep feelings.
The piano quartet is unique by its composition. It lacks the general thematic development, i. E.it is based on the mutual transition of the variations, which is expressed very brightly.
Pilgrimage in Tayk Ashkharh
Authors: Avetisyan Gagik 
Published: July 2024

Thus, having comprehensively studied the historical process and the current state of the monuments of the Tayk, we came to the following conclusions.

The current competent authorities of Turkey, cooperating with their Georgian colleagues with the involvement of relevant specialists, restore several famous Armenian monumental monuments of Tayk in accordance with the Chalcedonian Canon.
Under the guise of restoration, by cutting out fragments of inscriptions confirming Armenian authenticity, native Armenian monuments are presented as Georgian heritage.
Some monuments have been vandalized and in the absence of proper attention, years later they will not even leave a trace.
For a significant part of the Armenians, pilgrimages to Western Armenia are limited only to visiting the central districts, mostly ignoring the Armenian Taуk.

Proceeding from the above, we believe that the most important condition for the formation of a patriot citizen continues to be an educated person who knows and appreciates his history and religion, one of the best ways of which is pilgrimage and exploring even the most remote places of the historical homeland from the main routes. Therefore, the problem of pilgrimage, research and constant monitoring of particularly remote, little-known and disputed parts of the lost homeland is now relevant and requires concrete solutions.
Tree-Ring Analysis of 445 Year Chronology of Scots Pine from Baikal National Park
Authors: Румянцев Д. , Черакшев А. 
Published: July 2024

Исследован методический аспект обработки дендрохронологической информации, связанной с выделением долговременной и кратковременной компонент изменчивости из временного ряда радиального прироста, полученного по трем кернам из старовозрастной сосны с острова Ольхон. Проанализированы различные варианты индексации хронологии и рассчитан коэффициент корреляции между хронологиями разного типа. По результатам исследования определен лучший вариант индексации. Для долговременной компоненты установлена связь с числами Вольфа, при этом она демонстрирует цикличность колебаний, соответствующую истинному Солнечному циклу.
The most part of known in present time long tree-ring chronologies were build with use of timber cores from wooden buildings and archeological timber samples, wchich were dated with use cores from living trees by cross-date method. Thus, they consist of dendrochronological information from several organisms. At the same time, the investigation of features of tree-rings forming by one genotype for maximally possible long time interval has the independent value for progress of our knowledge about biological base of radial growth variability and the wood stock forming. The goal of investigation wath the analisys of radial growth variability in uncial ald-age tree of Scots pine (Pinus sylvestris L.) The length of investigated chronology was 445 years. The investigated tree is situated on Baycal island Olchon in forest on sandy soils near Saraysk bay. Three cores were taken by Pressler borer and was delivered to the laboratory where specially prepared for future research. Rings width were measured and analysed with use of special equipment Lintab and computer program TSAP. By results of measuring of each core was made three individual chronology, and on the base of them was calculated the average chronology. The correlation between absolutely value of radial growth chronologies and chchronologies calculated by indexation with use of different variants of growth norm; the features of long-term component of the radial growth calculated by method of of 11-year moving average; features of correlation between sunspot activity and long-term and short-term components of radial growth were investigated. It was established, that for investigation of short-term variability of radial growth and effect of climate changes on radial growth the best variant of indexation is on the base of 5-year average norm of ring width. Also it was established, that impact of solar activity on radial growth has nonstationary function and probably modified by impact of other astrophysical factors.