bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovering prominent differences in structural and functional connectomes using a multinomial stochastic block model
Authors: Iskov Nina Braad , Olsen Anders Stevnhoved , Madsen Kristoffer Hougaard , Mørup Morten 
Published: June 2024

Abstract
Understanding the differences between functional and structural human brain connectivity has been a focus of an extensive amount of neuroscience research. We employ a novel approach using the multinomial stochastic block model (MSBM) to explicitly extract components that characterize prominent differences across graphs. We analyze structural and functional connectomes derived from high-resolution diffusion-weighted MRI and fMRI scans of 250 Human Connectome Project subjects, analyzed at group connectivity level across 50 subjects. The inferred brain partitions revealed consistent, spatially homogeneous clustering patterns across inferred resolutions demonstrating the MSBM’s reliability in identifying brain areas with prominent structure-function differences. Prominent differences in low-resolution brain maps (K = {3, 4} clusters) were attributed to weak functional connectivity in the bilateral anterior temporal lobes, while higher resolution results (K ≥ 25) revealed stronger interhemispheric functional than structural connectivity. Our findings emphasize significant differences in high-resolution functional and structural connectomes, revealing challenges in extracting meaningful connectivity measurements from both modalities, including tracking fibers through the corpus callosum and attenuated functional connectivity in anterior temporal lobe fMRI data, which we attribute to increased noise levels. The MSBM emerges as a valuable tool for understanding differences across graphs, with potential future applications and avenues beyond the current focus on characterizing modality-specific distinctions in connectomics data.
Framework for personalized prediction of treatment response in relapsing-remitting multiple sclerosis: a replication study in independent data
Authors: Sakr Anna Maria , Mansmann Ulrich , Havla Joachim , Ön Begum Irmak , Ön Begum Irmak 
Published: June 2024

Abstract
Background
Individualizing and optimizing treatment of relapsing-remitting multiple sclerosis patients is a challenging problem, which would benefit from a clinically valid decision support. Stühler et al. presented black box models for this aim which were developed and internally evaluated in a German registry but lacked external validation.

Methods
In patients from the French OFSEP registry, we independently built and validated models predicting being free of relapse and free of confirmed disability progression (CDP), following the methodological roadmap and predictors reported by Stühler. Hierarchical Bayesian models were fit to predict the outcomes under 6 disease-modifying treatments given the individual disease course up to the moment of treatment change. Data was temporally split on 2017, and models were developed in patients treated earlier (n = 5517). Calibration curves, discrimination, mean squared error (MSE) and relative percentage of root MSE (RMSE%) were assessed by external validation of models in more-recent patients (n = 3768). Non-Bayesian fixed-effects GLMs were also applied and their outcomes were compared to these of the Bayesian ones. For both, we modelled the number of on-therapy relapses with a negative binomial distribution, and CDP occurrence with a binomial distribution.

Results
The performance of our temporally-validated relapse model (MSE: 0.326, C-Index: 0.639) is potentially superior to that of Stühler’s (MSE: 0.784, C-index: 0.608). Calibration plots revealed miscalibration. Our CDP model (MSE: 0.072, C-Index: 0.777) was also better than its counterpart (MSE: 0.131, C-index: 0.554). Results from non-Bayesian fixed-effects GLM models were similar to the Bayesian ones.

Conclusions
The relapse and CDP models rebuilt and externally validated in independent data could compare and strengthen the credibility of the Stühler models. Their model-building strategy was replicable.
Do symptoms and signs of temporomandibular disorders have an association with breathing pattern: a cross-sectional study on Turkish children and adolescents
Authors: Alpaydin Mehmed Taha , Alpaydin Tugce , Torul Damla 
Published: June 2024

Abstract
Background
This paper aimed to explore the prevalence of temporomandibular disorders (TMDs) signs/symptoms, and to investigate the possible link between signs/symptoms of TMDs and mouth breathing (MB) by evaluating along with other risk factors, in a Turkish subpopulation of children and adolescence.

Methods
This study was conducted with the archival data of the patients who applied with orthodontic complaints. Data on demographic characteristics, family-related factors, systemic status, occlusion, breathing patterns, oral habits, and bruxism were retrieved from the archival records.

Results
Nine hundred forty-five children and adolescents with a mean age of 14.82 ± 2.06 years were included in the study. Of the participants, 66% were girls, 60.4% were delivered by C-section, 8.4% of the participants had at least one systemic disease, 9.2% of the participants had allergy, and 4.3% of the participants’ parents were divorced, 18.7% have an oral habit, 6.6% have bruxism, 29.8% have malocclusion and 14.1% have MB. Eight-point-five percent of participants have signs/symptoms of TMD. Among them 2.9% have pain, 3.7% have joint sounds, 1.4% have deflection, and 3.9% have deviation. Evaluation of the risk factors revealed a significant relation between the signs/symptoms of TMD and bruxism (OR 8.07 95% CI 4.36–14.92), gender (OR 2.01 95% CI 1.13–3.59), marital status of parents (OR 2.62 95% CI 1.07–6.42), and MB (OR 3.26 95% CI 1.86–5.71).

Conclusions
According to the study’s findings, girls and those with bruxism, divorced parents, and MB behavior are more likely to have signs/symptoms of TMD. Age found to have significant effect on the occurrence of the signs/symptoms of TMD alone, but together with other factors the effect of the age is disappeared. Early screening and intervention of MB as well as the signs/symptoms of TMD can help to limit detrimental effects of these conditions on growth, and quality of life of children and adolescents.
Off-plane technique ultrasound-guided pericardiocentesis via anterior approach: short communication
Authors: Rodriguez Lima David Rene , Otálora González Laura , Noriega Acosta Felipe 
Published: June 2024

AbstractThe pericardiocentesis procedure is common, often performed via the subxiphoid approach, although other transthoracic approaches have been described. This short communication describes an off-plane technique ultrasound-guided pericardiocentesis using an anterior approach, performed using a linear transducer and guided in real-time by ultrasound, offering the advantage of continuous needle tracking to reduce complications associated with this approach such as pneumothorax, inadvertent cardiac puncture, and injury to the left internal mammary artery (LIMA).
A comprehensive database of human and livestock fecal microbiome for community-wide microbial source tracking: a case study in South Korea
Authors: Song Hokyung , Unno Tatsuya 
Published: June 2024

AbstractFecal waste from livestock farms contains numerous pathogens, and improperly managed waste may flow into water bodies, causing water-borne diseases. Along with the popularization of high-throughput technologies, community-wide microbial source-tracking methods have been actively developed in recent years. This study aimed to construct a comprehensive fecal microbiome database for community-wide microbial source tracking and apply the database to identify contamination sources in the Miho River, South Korea. Total DNA was extracted from the samples, and the 16 S rRNA gene was amplified to characterize the microbial communities. The fecal microbiome database was validated by developing machine-learning models that predict host species based on microbial community structure. All machine learning models developed in this study showed high performance, where the area under the receiver operating characteristic curve was approximately 1. Community-wide microbial source tracking results showed a higher contribution of fecal sources to the contamination of the main streams after heavy rain. In contrast, the contribution of fecal sources remained comparatively stable in tributaries after rainfall. Considering that farms are more concentrated upstream of tributaries compared to the main streams, this result implies that the pathway for manure contaminants to reach the main streams could be groundwater rather than surface runoff. Systematic monitoring of the water quality, which encompasses river water and groundwater, should be conducted in the future. In addition, continuous efforts to identify and plug abandoned wells are necessary to prevent further water contamination.
Effects of memory and attention on the association between video game addiction and cognitive/learning skills in children: mediational analysis
Authors: Kappi Amani Ali , El-Etreby Rania Rabie , Badawy Ghada Gamal , Ebrahem Gawhara , Hamed Warda El Shahat 
Published: June 2024

Abstract
Background
Video games have become a prevalent source of entertainment, especially among children. Furthermore, the amount of time spent playing video games has grown dramatically. The purpose of this research was to examine the mediation effects of attention and child memory on the relationship between video games addiction and cognitive and learning abilities in Egyptian children.

Methods
A cross-sectional research design was used in the current study in two schools affiliated with Dakahlia District, Egypt. The study included 169 children aged 9 to 13 who met the inclusion criteria, and their mothers provided the questionnaire responses. The data collection methods were performed over approximately four months from February to May. Data were collected using different tools: Socio-demographic Interview, Game Addiction Scale for Children (GASC), Children’s Memory Questionnaire (CMQ), Clinical Attention Problems Scale, Learning, Executive, and Attention Functioning (LEAF) Scale.

Results
There was a significant indirect effect of video game addiction on cognitive and learning skills through attention, but not child memory. Video game addiction has a significant impact on children’s attention and memory. Both attention and memory have a significant impact on a child’s cognitive and learning skills.

Conclusions
These results revealed the significant effect of video game addiction on cognitive and learning abilities in the presence of mediators. It also suggested that attention-focused therapies might play an important role in minimizing the harmful effects of video game addiction on cognitive and learning abilities.
Occurrence of pendelluft during ventilator weaning with T piece correlated with increased mortality in difficult-to-wean patients
Authors: Liu Wanglin , Chi Yi , Zhao Yutong , He Huaiwu , Long Yun , Zhao Zhanqi 
Published: June 2024

Abstract
Background
Difficult-to-wean patients, typically identified as those failing the initial spontaneous breathing trial (SBT), face elevated mortality rates. Pendelluft, frequently observed in patients experiencing SBT failure, can be conveniently detected through bedside monitoring with electrical impedance tomography (EIT). This study aimed to explore the impact of pendelluft during SBT on difficult-to-wean patients.

Methods
This retrospective observational study included difficult-to-wean patients undergoing spontaneous T piece breathing, during which EIT data were collected. Pendelluft occurrence was defined when its amplitude exceeded 2.5% of global tidal impedance variation. Physiological parameters during SBT were retrospectively retrieved from the EIT Examination Report Form. Other clinical data including mechanical ventilation duration, length of ICU stay, length of hospital stay, and 28-day mortality were retrieved from patient records in the hospital information system for each subject.

Results
Pendelluft was observed in 72 (70.4%) of the 108 included patients, with 16 (14.8%) experiencing mortality by day 28. The pendelluft group exhibited significantly higher mortality (19.7% vs. 3.1%, p = 0.035), longer median mechanical ventilation duration [9 (5–15) vs. 7 (5–11) days, p = 0.041] and shorter ventilator-free days at day 28 [18 (4–22) vs. 20 (16–23) days, p = 0.043]. The presence of pendellfut was independently associated with increased mortality at day 28 (OR = 10.50, 95% confidence interval   1.21–90.99, p = 0.033).

Conclusions
Pendelluft occurred in 70.4% of difficult-to-wean patients undergoing T piece spontaneous breathing. Pendelluft was associated with worse clinical outcomes, including prolonged mechanical ventilation and increased mortality in this population. Our findings underscore the significance of monitoring pendelluft using EIT during SBT for difficult-to-wean patients.
Distinct leaflet-annular remodeling pattern in severe atrial functional mitral regurgitation: a three-dimensional echocardiography study
Authors: Abdelgawad Hoda , Mowafy Bassant , Khidr Kawkab , Elsharkawy Eman 
Published: June 2024

Abstract
Background
Atrial functional mitral regurgitation (AFMR) is best described with normal left ventricular size and function, structurally normal mitral leaflets and dilated left atrium. Unlike the ventricular functional phenotype, changes in the annular geometry more than the tethering forces are the main culprit for mitral regurgitation. The aim of this study is to illuminate the leaflet-annular remodeling in patients with mitral regurgitation and atrial fibrillation (AF) using three-dimensional transesophageal echocardiography (3D TOE).

Results
Consecutive fifty patients with AFMR underwent transthoracic echocardiography and 3D TOE: 25 patients with AF and non-mild MR and 25 patients with AF and mild MR were studied. A special mitral valve analysis software was used to accurately assess the three unique pillars for MR: annular size, leaflets’ geometry and tenting parameters.
Compared to the mild MR group, non-mild MR group had long-standing AF of more than 1 year and larger left atrial volumes (51.83 ± 12.07 ml/m2 vs 33.68 ± 10.97 ml/m2, p < 0.001). No significant differences were noted in respect of tenting height, area and volume (13.06 ± 2.57 mm vs 11.43 ± 2.89 mm, p = 0.064, 3.58 ± 1.26 cm2 vs 2.80 ± 0.95 cm2, 0.081 and 6.70 ± 2.96 cm3 vs 5.04 ± 2.32 cm3, p = 0.081). Conversely, the non-mild MR group had larger annular area and perimeter (16.20 ± 3.90 cm2 vs 13.51 ± 3.85 cm2, p = 0.023 and 14.73 ± 1.72 cm vs 13.46 ± 1.79 cm, p = 0.033). Similarly, the non-mild MR group had larger anterior and posterior leaflets’ areas (10.18 ± 4.02 cm2 vs 8.71 ± 3.08 cm2, p = 0.04 and 8.96 ± 2.60 cm2 vs 7.30 ± 2.17 cm2, p = 0.029). Correspondingly, more disproportionate leaflet-annular remodeling, as assessed by the ratio of total leaflets’ area to the annular area, was noted in the non-mild MR as opposed to the mild MR group (1.22 ± 0.04 vs 1.26 ± 0.04, p = 0.008).

Conclusions
Recently, AFMR has been recognized as a remarkable entity of secondary MR with unique mechanisms. Annular dilatation with disproportionate leaflet remodeling can validate the central regurgitation. However, the call for more parameters is being emphasized to characterize the suitable candidates for percutaneous interventions.

Graphical abstract
Clinical predictors of obstructive sleep apnea among residents of Sagamu local government area of Ogun State
Authors: Olalekan S. O. , Osonuga I. O. , Okwute P. G. , Atekoja O. E. , Adeyanju M. M. , Adegbesan B. O. , Ezima E. N. , Odufejo O. D. , Tayo B. , Edema V. B. , Taiwo D. D. 
Published: June 2024

Abstract
Background
Obstructive sleep apnea (OSA) is the most commonly diagnosed sleep-associated pulmonary disorder in the world. So many risk factors have been attributed to OSA; however, conflicting results exist on how these factors contribute to OSA.

Purpose
This study hypothesized that increasing the number of risk factors for OSA, as reflected in the STOP-BANG questionnaire, increases the probability of having OSA but also increases the likelihood of having other severe diseases such as hypertension in a Nigerian population and that the severity of OSA might be dependent on specific anthropometric indices.

Methods
This study involved 110 male and female residents of Sagamu Local Government Area of Ogun State. Data was collected using a standardized instrument and the STOP-BANG questionnaire. Analysis involved descriptive statistics, parametric test of independent t-test to characterize data based on gender, and multinomial regressions to determine predictive factors of the various parameters of study on the severity of OSA.

Results
The association of the male gender with higher risk of OSA was confirmed by this study. Diastolic blood pressure (DBP) and heart rate (HR) predicted the risk of OSA, with an increase in DBP and HR implying higher risk of OSA. Of the anthropometric tests examined in this study, body mass index (BMI), neck circumference (NC), and neck height ratio (NHtR) predicted the risk of OSA in comparing low risk and medium risk to high risk, an increase in BMI and NC implying a higher risk of OSA while an increase in NHtR implying a lower risk of OSA.
Nanomaterial strategies for enhancing plant resilience in the face of temperature stress
Authors: Sidhu Amanpreet K. , Sharma Madhvi , Bhickchand Agrawal Sanskruthi , Pradip Bhavsar Praneeta , Samota Mahesh Kumar 
Published: June 2024

Abstract
Plant growth and productivity are greatly impacted by temperature stress, both high and low. These stresses impair biochemical, physiological, and molecular processes in the plant, eventually affecting plant growth, development, and productivity. Consequently, novel approaches are needed to overcome these problems and achieve sustainability. Nanotechnology is one such novel approach to improving crop production, by using nanoscale products. Nanoparticle size, nature, application mode, environmental conditions, rhizospheric and phyllospheric environments, and the species of plant make a significant impact on their action. With their easy soluble nature, smaller size, and excellent ability to penetrate plants, and their ability to cross cellular barriers, nanoparticles have become an increasingly popular agricultural tool. It has recently been observed that silver, silicon, titanium, and selenium nanoparticles can alter the physiological and biochemical response of plants in order to counteract high or low temperature stress. In this review, a description is provided of how nanoparticles are absorbed in different plant parts and how they are translocate along with the factors that influence their uptake and translocation. Also how plant response to nanoparticles in temperature stress and the various types of physiological, morphological, anatomical, biochemical and molecular modifications caused by nanoparticles. The review is going to provide researchers in agricultural sciences a glimpse into how to discover new nanoparticles to deal with heat stress.
Tianjin’s Italian-Style town: the conundrum between conservation practices and heritage value
Authors: Wang Jingting , Marinelli Maurizio 
Published: June 2024

Abstract
The former Italian concession in Tianjin (1901–1945) has assumed symbolic significance for the modern urban redevelopment of this municipality through experimentation with distinctive practices of conservation management. In 1986, when the Historic Buildings Protection Area was defined, the former Italian concession was identified as a pilot urban conservation project. In 2002, the public company Haihe Construction and Development Investment Ltd. was put in charge of the design and implementation plan for the site, which progressively assumed the semblance of an ‘Italian-Style Town’. The distinctive transformation raised significant questions regarding the architectural restyling as well as its specific historical and cultural value. In August 2020, the management of the Italian-Style town was handed over to the Hebei District Government. This coincided with the emergence of a proposal for the creation of a ‘Larger Italian-Style Town’, that extended beyond the borders of the original Italian concession to include the former Austrian concession and the western section of the ex-Russian concession. The redevelopment strategy for this larger area aimed to create a service-oriented commercial area, presented as an ‘urban living room’, while showcasing Tianjin as an international metropolis.
This article analyses the evolution of the conservation strategy as well as the relevant legislation, management, and practices during the redevelopment of the former Italian concession. The aim of this study is to address the conflict between heritage protection and commercialisation. Thus, this article offers a critique of the trend towards functional replacement and structural adaptation to cater to the tourism industry rather than to the value of the community’s livelihood as a living heritage.
Assessing Mobility in Patients With Glioblastoma Using Digital Phenotyping—Piloting the Digital Assessment in Neuro-Oncology
Authors: Nawabi Noah L. A. , Emedom-Nnamdi Patrick , Kilgallon John L. , Gerstl Jakob V. E. , Cote David J. , Jha Rohan , Ellen Jacob G. , Maniar Krish M. , Hong Christopher S. , Dawood Hassan Y. , Onnela Jukka-Pekka , Smith Timothy R. 
Published: June 2024

BACKGROUND AND OBJECTIVES:
Digital phenotyping (DP) enables objective measurements of patient behavior and may be a useful tool in assessments of quality-of-life and functional status in neuro-oncology patients. We aimed to identify trends in mobility among patients with glioblastoma (GBM) using DP.

METHODS:
A total of 15 patients with GBM enrolled in a DP study were included. The Beiwe application was used to passively collect patient smartphone global positioning system data during the study period. We estimated step count, time spent at home, total distance traveled, and number of places visited in the preoperative, immediate postoperative, and late postoperative periods. Mobility trends for patients with GBM after surgery were calculated by using local regression and were compared with preoperative values and with values derived from a nonoperative spine disease group.

RESULTS:
One month postoperatively, median values for time spent at home and number of locations visited by patients with GBM decreased by 1.48 h and 2.79 locations, respectively. Two months postoperatively, these values further decreased by 0.38 h and 1.17 locations, respectively. Compared with the nonoperative spine group, values for time spent at home and the number of locations visited by patients with GBM 1 month postoperatively were less than control values by 0.71 h and 2.79 locations, respectively. Two months postoperatively, time spent at home for patients with GBM was higher by 1.21 h and locations visited were less than nonoperative spine group values by 1.17. Immediate postoperative values for distance traveled, maximum distance from home, and radius of gyration for patients with GBM increased by 0.346 km, 2.24 km, and 1.814 km, respectively, compared with preoperative values.

CONCLUSIONS
:Trends in patients with GBM mobility throughout treatment were quantified through the use of DP in this study. DP has the potential to quantify patient behavior and recovery objectively and with minimal patient burden.