bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the functional regression model and its finite-dimensional approximations
Authors: Berrendero José R. , Cholaquidis Alejandro , Cuevas Antonio 
Published: July 2024

AbstractThe problem of linearly predicting a scalar response Y from a functional (random) explanatory variable $$X=X(t),\ t\in I$$

X
=
X
(
t
)
,

t
∈
I

is considered. It is argued that the term “linearly” can be interpreted in several meaningful ways. Thus, one could interpret that (up to a random noise) Y could be expressed as a linear combination of a finite family of marginals $$X(t_i)$$

X
(

t
i

)

of the process X, or a limit of a sequence of such linear combinations. This simple point of view (which has some precedents in the literature) leads to a formulation of the linear model in terms of the RKHS space generated by the covariance function of the process X(t). It turns out that such RKHS-based formulation includes the standard functional linear model, based on the inner product in the space $$L^2[0,1]$$

L
2

[
0
,
1
]

, as a particular case. It includes as well all models in which Y is assumed to be (up to an additive noise) a linear combination of a finite number of linear projections of X. Some consistency results are proved which, in particular, lead to an asymptotic approximation of the predictions derived from the general (functional) linear model in terms of finite-dimensional models based on a finite family of marginals $$X(t_i)$$

X
(

t
i

)

, for an increasing grid of points $$t_j$$

t
j

in I. We also include a discussion on the crucial notion of coefficient of determination (aimed at assessing the fit of the model) in this setting. A few experimental results are given.
Comparison of low versus high (standard) intraabdominal pressure during laparoscopic colorectal surgery: systematic review and meta-analysis
Authors: Hamid Mohammed , Mostafa Omar E. S. , Mohamedahmed Ali Yasen Y. , Zaman Shafquat , Kumar Prajeesh , Waterland Peter , Akingboye Akinfemi 
Published: July 2024

Abstract
Background
To evaluate outcomes of low with high intraabdominal pressure during laparoscopic colorectal resection surgery.

Methods
A systematic search of multiple electronic data sources was conducted, and all studies comparing low with high (standard) intraabdominal pressures were included. Our primary outcomes were post-operative ileus occurrence and return of bowel movement/flatus. The evaluated secondary outcomes included: total operative time, post-operative haemorrhage, anastomotic leak, pneumonia, surgical site infection, overall post-operative complications (categorised by Clavien-Dindo grading), and length of hospital stay. Revman 5.4 was used for data analysis.

Results
Six randomised controlled trials (RCTs) and one observational study with a total of 771 patients (370 surgery at low intraabdominal pressure and 401 at high pressures) were included. There was no statistically significant difference in all the measured outcomes; post-operative ileus [OR 0.80; CI (0.42, 1.52), P = 0.50], time-to-pass flatus [OR -4.31; CI (-12.12, 3.50), P = 0.28], total operative time [OR 0.40; CI (-10.19, 11.00), P = 0.94], post-operative haemorrhage [OR 1.51; CI (0.41, 5.58, P = 0.53], anastomotic leak [OR 1.14; CI (0.26, 4.91), P = 0.86], pneumonia [OR 1.15; CI (0.22, 6.09), P = 0.87], SSI [OR 0.69; CI (0.19, 2.47), P = 0.57], overall post-operative complications [OR 0.82; CI (0.52, 1.30), P = 0.40], Clavien-Dindo grade ≥ 3 [OR 1.27; CI (0.59, 2.77), P = 0.54], and length of hospital stay [OR -0.68; CI (-1.61, 0.24), P = 0.15].

Conclusion
Low intraabdominal pressure is safe and feasible approach to laparoscopic colorectal resection surgery with non-inferior outcomes to standard or high pressures. More robust and well-powered RCTs are needed to consolidate the potential benefits of low over high pressure intra-abdominal surgery.
6,126 hepatectomies in 2022: current trend of outcome in Italy
Authors: Nicolazzi Marco , Di Martino Marcello , Baroffio Paolo , Donadon Matteo 
Published: July 2024

Abstract

Purpose
Whether hospital volume affects outcome of patients undergoing hepatobiliary surgery, and whether the centralization of such procedures is justified remains to be investigated. The aim of this study was to analyze the outcome of liver surgery in Italy in relationship of hospital volume.

Methods
This is a nationwide retrospective observational study conducted on data collected by the National Italian Registry “Piano Nazionale Esiti” (PNE) 2023 that included all liver procedures performed in 2022. Outcome measure were case volume and 30-day mortality. Hospitals were classified as very high-volume (H-Vol), intermediate-volume (I-Vol), low-volume (L-Vol) and very low-volume (VL-VoL). A review on centralization process and outcome measures was added.

Results
6,126 liver resections for liver tumors were performed in 327 hospitals in 2022. The 30-day mortality was 2.2%. There were 14 H-Vol, 19 I-Vol, 31 L-Vol and 263 VL-Vol hospitals with 30-day mortality of 1.7%, 2.2%, 2.6% and 3.6% respectively (P < 0.001); 220 centers (83%) performed less than 10 resections, and 78 (29%) centers only 1 resection in 2022. By considering the geographical macro-areas, the median count of liver resection performed in northern Italy exceeded those in central and southern Italy (57% vs. 23% vs. 20%, respectively).

Conclusions
High-volume has been confirmed to be associated to better outcome after hepatobiliary surgical procedures. Further studies are required to detail the factors associated with mortality. The centralization process should be redesigned and oversight.
On join-complete implication algebras
Authors: Yon Yong Ho , Özbal Şule Ayar 
Published: July 2024

AbstractIn this paper, first, we consider an algebra that has a binary operation and a join of arbitrary nonempty subset. A lattice implication algebra is a lattice with a binary operation, which has a join and a meet of finite nonempty subsets. In this work, the notion of join-complete implication algebras L is defined as a join-complete lattice with a binary operation, and some properties of this algebra L are searched. Moreover, we prove that the interval [a, 1] in L is a lattice implication algebra and show that L satisfies the completely distributive law when it has the smallest element 0. Finally, we state the concept of filter and multipliers of L and provide finite and infinite examples of them. In addition, we research some properties of these concepts in detail.
“Not me!” a qualitative, vignette-based study of nurses’ and physicians’ reactions to spiritual distress on neuro-oncological units
Authors: Völz Daniela , Grabenweger Reinhard , Best Megan C. , Hau Peter , Jones Kate F. , Linker Ralf , Paal Piret , Bumes Elisabeth 
Published: July 2024

Abstract
Purpose
People with primary malignant brain tumors experience serious health-related suffering caused by limited prognosis and high symptom burden. Consequently, neuro-oncological healthcare workers can be affected emotionally in a negative way. The aim of this study was to analyze the attitudes and behavior of nurses and physicians when confronted with spiritual distress in these patients.

Methods
Neurospirit-DE is a qualitative vignette–based, multicenter, cross-sectional online survey that was conducted in Bavaria, Germany. Reflexive thematic analysis was used for data analysis.

Results
A total of 143 nurses and physicians working in neurological and neurosurgical wards in 46 hospitals participated in the survey. The participants questioned if the ability to provide spiritual care can be learned or is a natural skill. Spiritual care as a responsibility of the whole team was highlighted, and the staff reflected on the appropriate way of involving spiritual care experts. The main limitations to spiritual care were a lack of time and not viewing spiritual engagement as part of the professional role. Some were able to personally benefit from spiritual conversations with patients, but many participants criticized the perceived emotional burden while expressing the imminent need for specific training and team reflection.

Conclusions
Most neuro-oncological nurses and physicians perceive spiritual care as part of their duty and know how to alleviate the patient’s spiritual distress. Nonetheless, validation of spiritual assessment tools for neuro-oncology and standardized documentation of patients’ distress, shared interprofessional training, and reflection on the professional and personal challenges faced when confronted with spiritual care in neuro-oncology require further improvement and training.
Variational problems for the system of nonlinear Schrödinger equations with derivative nonlinearities
Authors: Hirayama Hiroyuki , Ikeda Masahiro 
Published: July 2024

AbstractWe consider the Cauchy problem of the system of nonlinear Schrödinger equations with derivative nonlinearlity. This system was introduced by Colin and Colin (Differ Int Equ 17:297–330, 2004) as a model of laser-plasma interactions. We study existence of ground state solutions and the global well-posedness of this system by using the variational methods. We also consider the stability of traveling waves for this system. These problems are proposed by Colin–Colin as the open problems. We give a subset of the ground-states set which satisfies the condition of stability. In particular, we prove the stability of the set of traveling waves with small speed for 1-dimension.
Understanding the GDPR from a requirements engineering perspective—a systematic mapping study on regulatory data protection requirements
Authors: Negri-Ribalta Claudia , Lombard-Platet Marius , Salinesi Camille 
Published: July 2024

AbstractData protection compliance is critical from a requirements engineering (RE) perspective, both from a software development lifecycle (SDLC) perspective and regulatory compliance. Not including these requirements from the early phases of the SDLC can prove costly and challenging afterward. The general data protection regulation (GDPR) from the European Union (EU) sets a list of requirements that organizations working within its scope should satisfy. However, these requirements are complex to work with, as legal prose tends to be vague and imprecise, and not all requirements have received the same attention from researchers. This study aims to identify the research published in RE for helping compliance with regulatory data protection requirements. We gathered and analyzed 90 articles from 2016 to 2022 through a systematic mapping study. We analyzed key trends in the sample, such as year of publication, publication venue, type of research, interdisciplinarity in the author’s background, GDPR focus of compliance element, and type of proposal. Our main findings show ongoing interest, mostly published in conferences, in achieving overall compliance with the GDPR and consent as the most popular topics. Other topics, such as cookies or children’s data, did not receive significant attention. Research over the whole RE process has been done. 20 (22%) of the papers have authors affiliated with non-computer science; however, most research seems not interdisciplinary. We finally discuss gaps in the literature, possible future areas of research, and the importance of interdisciplinary research for regulatory data protection requirements in RE.
Twenty-year changes of adolescent mental health and substance use: a Finnish population-based time-trend study
Authors: Mishina Kaisa , Heinonen Emmi , Lempinen Lotta , Sourander Andre 
Published: July 2024

Abstract
This time-trend study assesses changes in mental health and substance use among Finnish adolescents from 1998 to 2018. Representative samples of adolescents (N = 6,600) aged 13–16 years participated in school-based, almost identical cross-sectional studies in 1998 (n = 1,446), 2008 (n = 2,009), 2014 (n = 1,800) and 2018 (n = 1,345), respectively. The Strengths and Difficulties Questionnaire was used to assess mental health. When comparing mental health in the clinical range between 1998 and 2018, the main finding was the significant increase of emotional symptoms among females. The percentage of females in the clinical range increased from 17.5 to 30.1% during the twenty-year period. When psychopathology measures were analyzed as continuous variables, the finding of increased emotional problems was confirmed. The study clearly illustrates a linear trend, with a consistent increase in emotional problems among females and decrease in substance use among both genders. An alarming finding of steady increase of self-reported emotional problems indicates the importance of early detection and evidence-based interventions for adolescent with anxiety and depression to prevent adversities associated with these disorders.
In silico-guided discovery and in vitro validation of novel sugar-tethered lysinated carbon nanotubes for targeted drug delivery of doxorubicin
Authors: Thakur Chanchal Kiran , Martins Fábio G. , Karthikeyan Chandrabose , Bhal Subhasmita , Kundu Chanakya Nath , Moorthy N. S. Hari Narayana , Sousa Sérgio F. 
Published: July 2024

Abstract
Context
Multiwalled carbon nanotubes (MWCNTs) functionalized with lysine via 1,3-dipolar cycloaddition and conjugated to galactose or mannose are potential nanocarriers that can effectively bind to the lectin receptor in MDA-MB-231 or MCF-7 breast cancer cells. In this work, a method based on molecular dynamics (MD) simulation was used to predict the interaction of these functionalized MWCNTs with doxorubicin and obtain structural evidence that allows a better understanding of the drug loading and release process. The MD simulations showed that while doxorubicin only interacted with pristine MWCNTs through π-π stacking interactions, functionalized MWCNTs were also able to establish hydrogen bonds, suggesting that the functionalized groups improve doxorubicin loading. Moreover, the elevated adsorption levels observed for functionalized nanotubes further support this enhancement in loading efficiency. MD simulations also shed light on the intratumoral pH-specific release of doxorubicin from functionalized MWCNTs, which is induced by protonation of the daunosamine moiety. The simulations show that this change in protonation leads to a lower absorption of doxorubicin to the MWCNTs. The MD studies were then experimentally validated, where functionalized MWCNTs showed improved dispersion in aqueous medium compared to pristine MWCNTs and, in agreement with the computational predictions, increased drug loading capacity. Doxorubicin-loaded functionalized MWCNTs demonstrated specific release of doxorubicin in tumor microenvironment (pH = 5.0) with negligible release in the physiological pH (pH = 7.4). Furthermore, doxorubicin-free MWNCT nanoformulations exhibited insignificant cytotoxicity. The experimental studies yielded nearly identical results to the MD studies, underlining the usefulness of the method. Our functionalized MWCNTs represent promising non-toxic nanoplatforms with enhanced aqueous dispersibility and the potential for conjugation with ligands for targeted delivery of anti-cancer drugs to breast cancer cells.

Methods
The computational model of a pristine carbon nanotube was created with the buildCstruct 1.2 Python script. The lysinated functionalized groups were added with PyMOL and VMD. The carbon nanotubes and doxorubicin molecules were parameterized using the general AMBER force field, and RESP charges were determined using Gaussian 09. Molecular dynamics simulations were carried out with the AMBER 20 software package. Adsorption levels were calculated using the water-shell function of cpptraj. Cytotoxicity was evaluated via a MTT assay using MDA-MB-231 and MCF-7 breast cancer cells. Drug uptake of doxorubicin and doxorubicin-loaded MWCNTs was measured by fluorescence microscopy.
Structural iterative rounding for generalized k-median problems
Authors: Gupta Anupam , Moseley Benjamin , Zhou Rudy 
Published: July 2024

AbstractThis paper considers approximation algorithms for generalized k-median problems. These problems can be informally described as k-median with a constant number of extra constraints, and includes k-median with outliers, and knapsack median. Our first contribution is a pseudo-approximation algorithm for generalized k-median that outputs a 6.387-approximate solution, with a constant number of fractional variables. The algorithm builds on the iterative rounding framework introduced by Krishnaswamy, Li, and Sandeep for k-median with outliers as reported (Krishnaswamy et al. in: Proceedings of the 50th Annual ACM SIGACT Symposium on Theory of Computing, 2018). The main technical innovation is allowing richer constraint sets in the iterative rounding and using the structure of the resulting extreme points. Using our pseudo-approximation algorithm, we give improved approximation algorithms for k-median with outliers and knapsack median. This involves combining our pseudo-approximation with pre- and post-processing steps to round a constant number of fractional variables at a small increase in cost. Our algorithms achieve approximation ratios $$6.994 + \epsilon $$

6.994
+
ϵ

and $$6.387 + \epsilon $$

6.387
+
ϵ

for k-median with outliers and knapsack median, respectively. These improve on the best-known approximation ratio $$7.081 + \epsilon $$

7.081
+
ϵ

for both problems as reported (Krishnaswamy et al. in: Proceedings of the 50th Annual ACM SIGACT Symposium on Theory of Computing, 2018).
The role of ureteric indocyanine green fluorescence in colorectal surgery: a retrospective cohort study
Authors: Rogers P. , Dourado J. , Wignakumar A. , Weiss B. , Aeshbacher P. , Garoufalia Z. , Strassmann V. , Emile S. , Strzempek P. , Wexner S. 
Published: July 2024

Abstract

Background
Ureteric injury (UI) is an infrequent but serious complication of colorectal surgery. Prophylactic ureteric stenting is employed to avoid UI, yet its efficacy remains debated. Intraoperative indocyanine green fluorescence imaging (ICG-FI) has been used to facilitate ureter detection. This study aimed to investigate the role of ICG-FI in identification of ureters during colorectal surgery and its impact on the incidence of UI.

Methods
A retrospective cohort study involving 556 consecutive patients who underwent colorectal surgery between 2018 and 2023 assessed the utility of routine prophylactic ureteric stenting with adjunctive ICG-FI. Patients with ICG-FI were compared to those without ICG-FI. Demographic data, operative details, and postoperative morbidity were analyzed. Statistical analysis included univariable regression.

Results
Ureteric ICG-FI was used in 312 (56.1%) patients, whereas 43.9% were controls. Both groups were comparable in terms of demographics except for a higher prevalence of prior abdominal surgeries in the ICG-FI group. Although intraoperative visualization was significantly higher in the ICG-FI group (95.3% vs 89.1%; p = 0.011), the incidence of UI was similar between groups (0.3% vs 0.8%; p = 0.585). Postoperative complications were similar between the two groups. Median stent insertion time was longer in the ICG-FI group (32 vs 25 min; p = 0.001).

Conclusion
Ureteric ICG-FI improved intraoperative visualization of the ureters but was not associated with a reduced UI rate. Median stent insertion time increased with use of ureteric ICG-FI, but total operative time did not. Despite its limitations, this study is the largest of its kind suggesting that ureteric ICG-FI may be a valuable adjunct to facilitate ureteric visualization during colorectal surgery.
Patterning strategies in grade 1 students with low and high number sense proficiency
Authors: Junker Astrid , Nortvedt Guri A. , Farsani Danyal 
Published: July 2024

Abstract
Repeating patterning proficiency predicts students’ later mathematical proficiency. A comparative multi-case design enabled the present study to compare patterning success and strategy use for repeating patterns of 75 Norwegian 6-year-old grade 1 students. We provided the students with duplicate, extend, transfer, and unit isolation activities in a semi-structured, task-based interview that was video-recorded. The students’ number sense was also measured using a digital assessment. In-depth analysis of 52 students (divided evenly into two groups based on their number sense scores, lowest and highest) was performed. A statistically significant group difference was found for extend activities. Multimodal video analysis of strategies employed revealed that both student groups used recursive and different strategies and only students with high number sense used relational strategies. The students with low number sense used more variants of recursive patterning strategies. Our findings also demonstrated that attention to pattern features may both hinder identification of a pattern’s underlying structure and reflect advanced strategy use rather than not showing pattern awareness. We discuss group differences in terms of decomposition and awareness of mathematical pattern and structure and emphasise the need for scaffolding awareness of mathematical pattern and structure through communication.
Accrual Quality, Cost of Debt, and Credit Spread and Loss
Authors: Tavakoli Baghdadabad Mohammadreza 
Published: July 2024

AbstractOur study presents a method to dissect bond excess returns into components influenced by credit spreads and credit losses. Analyzing data spanning 48 years, we find that companies with higher accrual quality experience greater shocks from credit spreads and lesser shocks from credit losses. Conversely, firms with lower accrual quality face reduced credit spread shocks but heightened credit loss shocks. This indicates that high accrual quality firms benefit more from credit spread shocks, while those with lower accrual quality profit more from credit loss shocks. Notably, excluding credit spread shocks, future realized returns have a negative correlation with accrual quality. These accrual quality premiums are significant both statistically and economically, especially when credit spread shocks are not considered. Additionally, accrual quality has improved over the past 48 years due to enhanced accounting standards. Our findings reveal the importance of a reliable accrual quality metric and underscore the need to factor in credit spread shocks in asset pricing evaluations.
Urban exodus or suburbanisation? Medium-term COVID-19 pandemic impacts on internal migration in Japan
Authors: Kotsubo Masaki , Nakaya Tomoki 
Published: July 2024

AbstractThe COVID-19 pandemic has profoundly affected internal migration patterns worldwide. Most previous studies have reported on pandemic-induced changes in internal migration using data from 2020 and 2021. Therefore, little is known about the pandemic’s medium-term impact. To address this gap, this study investigated an annual series of migration patterns from 2019 to 2023 in Japan. At the municipal level, relationships between net migration rates and population density indicated that the urbanisation trend became weak in 2020, compared to that in 2019, and it was the weakest in 2021. The urbanisation degree became stronger in 2023, increasing to the level in 2020. Using annual inter-municipal migration flows, this study then investigated changes in migration flows to/from and within three major metropolitan areas (Tokyo, Nagoya, and Osaka). The changes in sizes of these flows and migration effectiveness index suggested that the pandemic had the largest impact in the Tokyo metropolitan area, among the three areas, and it stimulated intra-metropolitan migration as suburbanisation, rather than net out-migration as ‘urban exodus’, in Japan. The overall results indicated that the pandemic had the largest impact in 2021, which got smaller as the migration patterns recovered to the pre-pandemic ones in 2023.