bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theory of mind in the early course of schizophrenia: stability, symptom and neurocognitive correlates, and relationship with functioning
Authors: Ventura J. , Ered A. , Gretchen-Doorly D. , Subotnik K. L. , Horan W. P. , Hellemann G. S. , Nuechterlein K. H. 
Published: February 2015

BackgroundNumerous studies have reported links between theory of mind (ToM) deficits, neurocognition and negative symptoms with functional outcome in chronic schizophrenia patients. Although the ToM deficit has been observed in first-episode patients, fewer studies have addressed ToM as a possible trait marker, neurocognitive and symptom correlations longitudinally, and associations with later functioning.MethodRecent-onset schizophrenia patients (n = 77) were assessed at baseline after reaching medication stabilization, and again at 6 months (n = 48). Healthy controls (n = 21) were screened, and demographically comparable with the patients. ToM was assessed with a Social Animations Task (SAT), in which the participants’ descriptions of scenes depicting abstract visual stimuli ‘interacting’ in three conditions (ToM, goal directed and random) were rated for degree of intentionality attributed to the figures and for appropriateness. Neurocognition, symptoms and role functioning were also assessed.ResultsOn the SAT, patients had lower scores than controls for both intentionality (p < 0.01) and appropriateness (p < 0.01) during the ToM condition, at baseline and 6 months. The ToM deficit was stable and present even in remitted patients. Analyses at baseline and 6 months indicated that for patients, ToM intentionality and appropriateness were significantly correlated with neurocognition, negative symptoms and role functioning. The relationship between ToM and role functioning was mediated by negative symptoms.ConclusionsThe ToM deficit was found in recent-onset schizophrenia patients and appears to be moderately trait-like. ToM is also moderately correlated with neurocognition, negative and positive symptoms, and role functioning. ToM appears to influence negative symptoms which in turn makes an impact on role functioning.
Experimental investigation and propulsion control for a bio-inspired robotic undulatory fin
Authors: Sfakiotakis Michael , Fasoulas John , Kavoussanos Manolis M. , Arapis Manolis 
Published: February 2015

SUMMARYUndulatory fin propulsion, inspired by the locomotion of aquatic species such as electric eels and cuttlefish, holds considerable potential for endowing underwater vehicles with enhanced propulsion and maneuvering abilities, to address the needs of a growing number of applications. However, there are still gaps in our understanding of the effect of the fin undulations' characteristics on the generated thrust, particularly within the context of developing propulsion control strategies for such robotic systems. Towards this end, we present the design and experimental evaluation of a robotic fin prototype, comprised of eight individually-actuated fin rays. An artificial central pattern generator (CPG) is used to produce the rays' undulatory motion pattern. Experiments are performed inside a water tank, with the robotic fin suspended from a carriage, whose motion is constrained via a linear guide. The results from a series of detailed parametric investigations reveal several important findings regarding the effect of the undulatory wave kinematics on the propulsion speed and efficiency. Based on these findings, two alternative strategies for propulsion control of the robotic fin are proposed. In the first one, the speed is varied through changes in the undulation amplitude, while the second one involves simultaneous adjustment of the undulation frequency and number of waves. These two strategies are evaluated via experiments demonstrating open-loop velocity control, as well as closed-loop position control of the prototype.
Syntactic and semantic coordination in finite complement-clause constructions: a diary-based case study
Authors: KÖYMEN BAHAR , LIEVEN ELENA , BRANDT SILKE 
Published: February 2015

AbstractThis study investigates the coordination of matrix and subordinate clauses within finite complement-clause constructions. The data come from diary and audio recordings which include the utterances produced by an American English-speaking child, L, between the ages 1;08 and 3;05. We extracted all the finite complement-clause constructions that L produced and compared the grammatical acceptability of these utterances with that of the simple sentences of the same length produced within the same two weeks and with that of the simple sentences containing the same verb produced within the same month. The results show that L is more likely to make syntactic errors in finite complement-clause constructions than she does in her simple sentences of the same length or with the same verb. This suggests that the errors are more likely to arise from the syntactic and semantic coordination of the two clauses rather than limitations in performance or lexical knowledge.
Hackerspaces: a case study in the creation and management of a common pool resource
Authors: WILLIAMS MICHAEL R. , HALL JOSHUA C. 
Published: February 2015

AbstractHackerspaces are community-operated physical places where individuals get together to build things. While the organization itself is private, the ‘space’ that is created for individuals to work has elements of a common pool resource (CPR). The previous literature finds technology to be important in effective CPR management. Through an ethnographic study of a hackerspace, we show how technology is crucial for management of the ‘space’. In addition, we highlight how technology is used in hackerspaces to satisfy three of Ostrom's design principles for stable CPR management.
SOLOVAY-TYPE THEOREMS FOR CIRCULAR DEFINITIONS
Authors: STANDEFER SHAWN 
Published: February 2015

AbstractWe present an extension of the basic revision theory of circular definitions with a unary operator, □. We present a Fitch-style proof system that is sound and complete with respect to the extended semantics. The logic of the box gives rise to a simple modal logic, and we relate provability in the extended proof system to this modal logic via a completeness theorem, using interpretations over circular definitions, analogous to Solovay’s completeness theorem forGLusing arithmetical interpretations. We adapt our proof to a special class of circular definitions as well as to the first-order case.
HOW A SEMANTICS FOR TONK SHOULD BE
Authors: FJELLSTAD ANDREAS 
Published: February 2015

AbstractThis paper explores how a semantics for Prior’s infamous connective tonk should be, a connective defined by inference rules that trivialize the logic of a deductive system if that logic is supposed to be transitive. To avoid triviality, one must reject transitivity and in a relatively recent paper, Roy Cook develops a semantics for tonk with non-transitive entailment. However, I show in this paper that a cut-free sequent calculus for tonk - the arguably most natural and simplest deductive system for a non-transitive logic - can neither be complete with respect to Cook’s semantics nor with respect to a semantics with non-transitive entailment based on a semantics for vagueness and transparent truth developed by Cobreros et al. It is argued that the failure to adequately represent tonk is connected with the fact that tonk is not uniquely defined in a cut-free sequent calculus system unless the logic is in addition non-reflexive. To remedy this, the paper develops a semantics with non-transitive and non-reflexive entailment based on the idea that complex formulae are true or false relative to them being assessed as premise or as conclusion.
Extraterritorial targeting by means of armed drones: Some legal implications
Authors: Pejic Jelena 
Published: February 2015

AbstractThe use of “drones” has grown exponentially over the past decade, giving rise to a host of legal and other issues. Internationally, it is the utilization of armed drones by States for the extraterritorial targeting of persons that has generated significant debate. This article attempts to outline some aspects of the relevant legal framework, with a focus on the international law applicable to drone strikes in situations of armed conflict. It briefly addresses thejus ad bellumand then centres on thejus in bello, addressing, in turn, questions related to when there is an armed conflict, what the rules on targeting are, who may be targeted and where persons may be targeted.
The More You Say, the Less They Hear
Authors: Asbeek Brusse Elsbeth D. , Fransen Marieke L. , Smit Edith G. 
Published: February 2015

Abstract. This study examined the effects of disclosure messages in entertainment-education (E-E) on attitudes toward hearing protection and attitude toward the source. In addition, the (mediating) role of the underlying mechanisms (i.e., transportation, identification, and counterarguing) was studied. In an experiment (N = 336), three different disclosure messages were compared with a no-disclosure condition. The results show that more explicit disclosure messages negatively affect transportation and identification and stimulate the generation of counterarguments. In addition, the more explicit disclosure messages affect both attitude measures via two of these processes (i.e., transportation and counterarguing). Less explicit disclosure messages do not have this effect. Implications of the findings are discussed.
Effects of Right-Wing Populist Political Advertising on Implicit and	Explicit Stereotypes
Authors: Arendt Florian , Marquart Franziska , Matthes Jörg 
Published: February 2015

Abstract. We investigated the effects of antiforeigner political advertisements on implicit and explicit stereotypes. While stereotypical associations may become automatically activated (implicit stereotypes), individuals can reject these thoughts and decide not to use them for an overtly expressed judgment (explicit stereotypes). We hypothesized that even if citizens negated stereotypical content, advertisements might still affect implicit stereotypes. This hypothesis was tested using an experiment where participants (N = 186) were exposed to zero, two, four, or six stereotypical advertisements. The results showed that stereotypical advertisements did not influence explicit stereotypes but did influence implicit stereotypes, even in critical recipients who negated the stereotypical content.
Human olfactory receptor responses to odorants
Authors: Mainland Joel D , Li Yun R , Zhou Ting , Liu Wen Ling L , Matsunami Hiroaki 
Published: February 2015

AbstractAlthough the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.
The pediatric template of brain perfusion
Authors: Avants Brian B , Duda Jeffrey T , Kilroy Emily , Krasileva Kate , Jann Kay , Kandel Benjamin T , Tustison Nicholas J , Yan Lirong , Jog Mayank , Smith Robert , Wang Yi , Dapretto Mirella , Wang Danny J J 
Published: February 2015

AbstractMagnetic resonance imaging (MRI) captures the dynamics of brain development with multiple modalities that quantify both structure and function. These measurements may yield valuable insights into the neural patterns that mark healthy maturation or that identify early risk for psychiatric disorder. The Pediatric Template of Brain Perfusion (PTBP) is a free and public neuroimaging resource that will help accelerate the understanding of childhood brain development as seen through the lens of multiple modality neuroimaging and in relation to cognitive and environmental factors. The PTBP uses cross-sectional and longitudinal MRI to quantify cortex, white matter, resting state functional connectivity and brain perfusion, as measured by Arterial Spin Labeling (ASL), in 120 children 7–18 years of age. We describe the PTBP and show, as a demonstration of validity, that global summary measurements capture the trajectories that demarcate critical turning points in brain maturation. This novel resource will allow a more detailed understanding of the network-level, structural and functional landmarks that are obtained during normal adolescent brain development.
Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis
Authors: Lai Tianwen , Wang Shaobin , Xu Zhiwei , Zhang Chao , Zhao Yun , Hu Yue , Cao Chao , Ying Songmin , Chen Zhihua , Li Wen , Wu Bin , Shen Huahao 
Published: February 2015

AbstractCurrently, limited information is available to clinicians regarding the long-term efficacy of omalizumab treatment for allergic asthma. In this report, we aimed to (i) systematically review the evidence regarding the long-term efficacy of omalizumab in patients with persistent uncontrolled allergic asthma and to (ii) discuss the cost-effectiveness evidence published for omalizumab in this patient population. A comprehensive search for randomized controlled trials (RCTs; ≥52 weeks) was performed and six studies met our final inclusion criteria (n = 2,749). Omalizumab was associated with significant improvements in quality of life and the Global Evaluation of Treatment Effectiveness. Omalizumab also allowed patients to completely withdraw from inhaled corticosteroid therapy and did not increase the overall incidence of adverse events. However, there was insufficient evidence that omalizumab reduced the incidence of exacerbations and the cost-effectiveness of omalizumab varied across studies. Our data indicated that omalizumab use for at least 52 weeks in patients with persistent uncontrolled allergic asthma was accompanied by an acceptable safety profile, but it lacked effect on the asthma exacerbations. Use of omalizumab was associated with a higher cost than conventional therapy, but these increases may be cost-effective if the medication is used in patients with severe allergic asthma.
Crystal structure of UbiX, an aromatic acid decarboxylase from the psychrophilic bacterium Colwellia psychrerythraea that undergoes FMN-induced conformational changes
Authors: Do Hackwon , Kim Soo Jin , Lee Chang Woo , Kim Han-Woo , Park Hyun Ho , Kim Ho Min , Park Hyun , Park HaJeung , Lee Jun Hyuck 
Published: February 2015

AbstractThe ubiX gene of Colwellia psychrerythraea strain 34H encodes a 3-octaprenyl-4-hydroxybenzoate carboxylase (CpsUbiX, UniProtKB code: Q489U8) that is involved in the third step of the ubiquinone biosynthesis pathway and harbors a flavin mononucleotide (FMN) as a potential cofactor. Here, we report the crystal structures of two forms of CpsUbiX: an FMN-bound wild type form and an FMN-unbound V47S mutant form. CpsUbiX is a dodecameric enzyme and each monomer possesses a typical Rossmann-fold structure. The FMN-binding domain of UbiX is composed of three neighboring subunits. The highly conserved Gly15, Ser41, Val47 and Tyr171 residues play important roles in FMN binding. Structural comparison of the FMN-bound wild type form with the FMN-free form reveals a significant conformational difference in the C-terminal loop region (comprising residues 170–176 and 195–206). Subsequent computational modeling and liposome binding assay both suggest that the conformational flexibility observed in the C-terminal loops plays an important role in substrate and lipid bindings. The crystal structures presented in this work provide structural framework and insights into the catalytic mechanism of CpsUbiX.
Interaction of Pseudostellaria heterophylla with Fusarium oxysporum f.sp. heterophylla mediated by its root exudates in a consecutive monoculture system
Authors: Zhao Yongpo , Wu Linkun , Chu Leixia , Yang Yanqiu , Li Zhenfang , Azeem Saadia , Zhang Zhixing , Fang Changxun , Lin Wenxiong 
Published: February 2015

AbstractIn this study, quantitative real-time PCR (qPCR) was used to determine the amount of Fusarium oxysporum, an important replant disease pathogen in Pseudostellaria heterophylla rhizospheric soil. Moreover, HPLC was used to identify phenolic acids in root exudates then it was further to explore the effects of the phenolic acid allelochemicals on the growth of F. oxysporum f.sp. heterophylla. The amount of F. oxysporum increased significantly in P. heterophylla rhizosphere soil under a consecutive replant system as monitored through qPCR analysis. Furthermore, the growth of F. oxysporum f.sp. heterophylla mycelium was enhanced by root exudates with a maximum increase of 23.8%. In addition, the number of spores increased to a maximum of 12.5-fold. Some phenolic acids promoted the growth of F. oxysporum f.sp. heterophylla mycelium and spore production. Our study revealed that phenolic acids in the root secretion of P. heterophylla increased long with its development, which was closely related to changes in rhizospheric microorganisms. The population of pathogenic microorganisms such as F. oxysporum in the rhizosphere soil of P. heterophylla also sharply increased. Our results on plant-microbe communication will help to better clarify the cause of problems associated with P. heterophylla under consecutive monoculture treatment.
A 2D-DIGE-based proteomic analysis reveals differences in the platelet releasate composition when comparing thrombin and collagen stimulations
Authors: Vélez Paula , Izquierdo Irene , Rosa Isaac , García Ángel 
Published: February 2015

AbstractUpon stimulation, platelets release a high number of proteins (the releasate). There are clear indications that these proteins are involved in the pathogenesis of several diseases, such as atherosclerosis. In the present study we compared the platelet releasate following platelet activation with two major endogenous agonists: thrombin and collagen. Proteome analysis was based on 2D-DIGE and LC-MS/MS. Firstly, we showed the primary role of thrombin and collagen receptors in platelet secretion by these agonists; moreover, we demonstrated that GPVI is the primary responsible for collagen-induced platelet activation/aggregation. Proteomic analysis allowed the detection of 122 protein spots differentially regulated between both conditions. After excluding fibrinogen spots, down-regulated in the releasate of thrombin-activated platelets, 84 differences remained. From those, we successfully identified 42, corresponding to 37 open-reading frames. Many of the differences identified correspond to post-translational modifications, primarily, proteolysis induced by thrombin. Among others, we show vitamin K-dependent protein S, an anticoagulant plasma protein, is up-regulated in thrombin samples. Our results could have pathological implications given that platelets might be playing a differential role in various diseases and biological processes through the secretion of different subsets of granule proteins and microvesicles following a predominant activation of certain receptors.
The fate of recent duplicated genes following a fourth-round whole genome duplication in a tetraploid fish, common carp (Cyprinus carpio)
Authors: Li Jiong-Tang , Hou Guang-Yuan , Kong Xiang-Fei , Li Chun-Yan , Zeng Jian-Ming , Li Heng-De , Xiao Gui-Bao , Li Xiao-Min , Sun Xiao-Wen 
Published: February 2015

AbstractWhole genome duplication (WGD) results in extensive genetic redundancy. In plants and yeast, WGD is followed by rapid gene deletions and intense expression differentiation with slow functional divergence. However, the early evolution of the gene differentiation processes is poorly understood in vertebrates because almost all studied WGDs are extremely ancient and the genomes have returned to a diploid status. Common carp had a very recent fourth round of WGD dated to 8 million years ago. It therefore constitutes an ideal model to study early-stage functional divergence and expression differentiation in vertebrates. We identified 1,757 pairs of recently duplicated genes (RDGs) originating from this specific WGD and found that most ancestral genes were retained in duplicate. Most RDGs were conserved and under selective pressure. Gene expression analysis across six tissues revealed that 92.5% of RDG pairs were co-expressed in at least one tissue and that the expression of nearly half pairs ceased to be strongly correlated, indicating slow spatial divergence but rapid expression dissociation. Functional comparison revealed that 25% of pairs had functional divergence, of which neo- and sub-functionalization were the main outcomes. Our analysis revealed slow gene loss but rapid and intense expression and function differentiation after WGD.
Homo-β-amino acid containing MBP(85–99) analogs alleviate experimental autoimmune encephalomyelitis
Authors: Kant Ravi , Pasi Shweta , Surolia Avadhesha 
Published: February 2015

AbstractMBP(85–99), an immuno-dominant epitope of myelin basic protein which binds to the major histocompatibility complex haplotype HLA-DR2 is widely implicated in the pathogenesis of multiple sclerosis. J5, an antagonist of MBP(85–99), that blocks the binding of MBP(85–99) to soluble HLA-DR2b much more efficiently than glatiramer acetate (a random copolymer comprising major MHC and T-cell receptor contact residues), was transformed into analogs with superior biological half-lives and antagonistic-activities by substitution of some of its residues with homo-β-amino acids. S18, the best analog obtained ameliorated symptoms of experimental autoimmune encephalomyelitis at least twice more effectively than glatiramer acetate or J5. S18 displayed marked resistance to proteolysis in-vitro; biological impact of which was evident in the form of delayed clinical onset of disease and prolonged therapeutic-benefits. Besides active suppression of MBP(85–99)-reactive CD4+ T-cells in-vitro and in-vivo S18 treatment also generated IL-4 producing CD4+ T-cell clones, through which protective effect could be transferred passively.
In PC3 prostate cancer cells ephrin receptors crosstalk to β1-integrins to strengthen adhesion to collagen type I
Authors: Yu Miao , Wang Jinghe , Muller Daniel J. , Helenius Jonne 
Published: February 2015

AbstractEph receptor (Eph) and ephrin signaling can play central roles in prostate cancer and other cancer types. Exposed to ephrin-A1 PC3 prostate cancer cells alter adhesion to extracellular matrix (ECM) proteins. However, whether PC3 cells increase or reduce adhesion and by which mechanisms they change adhesion to the ECM remains to be characterized. Here, we assay how ephrin-A1 stimulates PC3 cells to adhere to ECM proteins using single-cell force spectroscopy. We find that PC3 cells binding to immobilized ephrin-A1 but not to solubilized ephrin-A1 specifically strengthen adhesion to collagen I. This Eph-ephrin-A1 signaling, which we suppose is based on mechanotransduction, stimulates β1-subunit containing integrin adhesion via the protein kinase Akt and the guanine nucleotide-exchange factor cytohesin. Inhibiting the small GTPases, Rap1 or Rac1, generally lowered adhesion of PC3 prostate cancer cells. Our finding suggests a mechanism by which PC3 prostate cancer cells exposed to ephrins crosstalk to β1-integrins and preferably metastasize in bone, a collagen I rich tissue.