bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increase in porosity and permeability resolution for thin-bedded Miocene formation in Carpathian Foredeep using different clustering methods
Authors: Waszkiewicz Sebastian , Krakowska-Madejska Paulina 
Published: August 2024

AbstractThe accurate interpretation of well-logging data is a crucial stage in the exploration of gas- and oil-bearing reservoirs. Geological formations, such as the Miocene deposits, present many challenges related to thin layers, whose thickness is often less than the measurement resolution. This research emphasizes the potential of utilizing electrofacies in such challenging environments. The application of electrofacies not only allows for the grouping of intervals with similar physical characteristics but can also be useful for estimating porosity and permeability parameters. For this purpose, various clustering methods were tested, including the 2D indexed and probabilized self-organizing map (IPSOM) method with and without supervision. Subsequently, the usefulness of the obtained results to improve the estimation of porosity and permeability parameters with the help of artificial neural networks was verified. As a result of the conducted analyses, significantly better results were obtained compared to classical petrophysical interpretation. The calculated porosity and permeability parameters were characterized by much greater variability and alignment with laboratory measurements on porosity and permeability. The best results were obtained for the IPSOM method, but the other methods did not differ significantly. In conclusion, the studies have shown a positive result of applying clustering methods, including the IPSOM method, to improve the estimation of permeability and porosity parameters in complicated, thinly-layered formations.
RoboticSurgery4all: are discovery courses important for robotic surgery skills acquisition?
Authors: Gonçalves Mário Rui , Mück Björn , Faure Jean-Pierre , Topart Philippe , Sousa Miguel Castelo-Branco 
Published: August 2024

AbstractCost, logistics, and availability of robotic simulation opportunities suppose a real challenge for robotic surgery training. We aimed to test a new methodology for introduction to robotic surgery pre-congress courses. Two different “introduction to robotic surgery” pre-congress courses were developed. A new methodology using a sleeve/bypass, a ventral TAPP and an inguinal TAPP silicone models was implemented. After the session, the trainees answered a questionnaire to evaluate the course and the methodology using 1–5 Likert scales. A total of 21 participants participated in the courses and (72.2%) had no experience in robotic surgery. All trainees rated the course as good or excellent. There was a strong agreement between participants regarding the adequacy of the silicone models for this type of simulation/course. Trainees agree that the course gave them more confidence to perform a real robotic procedure, increased their interest in robotic surgery and made them feel ready to start their robotic surgery pathway. Congresses are a frequent way of contact between surgeons and robotic systems, mostly in the form of technical demonstrations or pre-congress courses. Our methodology showed that it is possible to allow for this contact in a low-cost way. This kind of courses is well received by congress delegates and have a positive educational impact. Despite of being "Discovery” courses, they have a positive impact on the congress, on the acquisition of robotic surgery skills and increase the interest in robotic surgery.
What Kind of ‘God’ do Hindu Arguments for the Divine Show? Five Novel Divine Attributes of Brahman
Authors: Frazier Jessica 
Published: August 2024

AbstractThis article describes the ultimate ground of reality, Brahman, as a single power unfolding in concert in all things. It uses counterfactual argumentation to imply that a cosmos must consist of telic causal orders or manifested ‘powers’ as its most granular building block – and that they must be unified into a single whole. It is based on an argument for a single causally-conditioning substrate of all things recorded in India’s classical Sāṃkhya Kārikā and Brahma Sūtras; this was used by scholastic Vedāntic thinkers including the non-dualist Śaṃkara and the ‘transformationist’ Bhedābheda thinker Śrīnivāsa. It takes up arguments for satkārya, the pre-existence of a thing’s various transformations in potentio within its substrate, and employs them to paint a picture of reality as an ordered yet entangled pattern of causal trajectories. These manifest as the changing world we know. While Vedānta’s main motivation for making the arguments was to prove monism, this conception of an ‘immanent cause’ of all was also seen as divine. We see how this accords with moves in contemporary analytic philosophy to shift away from a broadly Humean model of constant conjunctions (reminiscent of key Buddhist approaches) toward a Neo-Aristotelian ‘metaphysics of powers’. But we also indicate how it may go further than most modern powers-metaphysicians in proposing a deeper connection between powers and what it is for there to be a cosmos at all.
Minibond and earnings management: leveraging the signaling effect of minibond listing
Authors: Bertacchini Federico , Grasso Alessandro Giovanni , Lugli Ennio , Russo Ivan 
Published: August 2024

AbstractMinibonds are a hybrid between bank debt and bond issuance introduced in Italy to expand the range of possible financing resources available to unlisted enterprises. This peculiar debt security was introduced as part of a regulatory reform in 2012 to diversify funding sources and facilitate access to capital markets for Small and Medium Enterprises (SMEs). In this study, we investigate whether firms that decide to issue and list a minibond engage in earnings management (EM) to leverage the growth-signaling effect generated by the listing of this security. Listing bonds on a financial market is not mandatory, but a strategic choice. Collecting a sample of 136 minibond listings during 2013–2020, we use panel analysis to show that issuers tend to manage their earnings in the year of listing. We argue that this behavior is undertaken in order to provide a better representation of their economic and financial situation and consequently to better impress current or future stakeholders. Moreover, we also find that larger minibond size partially discourages EM, thus confirming the role of debt as a means of control over management. Overall, we argue that stakeholders should be aware that, even though minibond issuers are sound firms on average, they tend to inflate their earnings in the year of listing in order to reinforce the signaling effect of the quotation.
Chronic pain in breast cancer survivors is linked with an impairment on emotion-based decisions and fatalistic time orientation
Authors: Masiero Marianna , Durosini Ilaria , Filipponi Chiara , Campanini Maria Luisa , Pravettoni Gabriella 
Published: August 2024

AbstractAfter breast cancer diagnosis, individuals have to cope with various psychological, social, and physical consequences. One such consequence is chronic pain, which can persist even after the completion of active treatments and detrimentally impact quality of life. The published literature highlights the impact of chronic pain on cognitive functions and on decision-making processes. However, little is known about the imbalance in decision-making among cancer survivors suffering from chronic pain. This study aims to explore the cognitive impairment associated with risky decision-making in breast cancer survivors experiencing chronic pain, using the Iowa Gambling Task (IGT). Sixty women voluntarily participated in this prospective, cross-sectional study. Among them, twenty had a history of breast cancer and exhibited a significant level of chronic pain, twenty had previously received a cancer diagnosis but did not experience chronic pain, and twenty had not been diagnosed with cancer. The results revealed that women with chronic pain tend to make significantly more disadvantageous choices in the IGT compared to the other groups. Moreover, participants with chronic pain tend to believe that circumstances will change regardless of their efforts to achieve something. This way of thinking may contribute to reinforcing the observed imbalance in decision-making. Our hypothesis suggests that chronic pain may trigger a “Cascade Effect”, exerting multiple influences on decision-making and behaviors. The cognitive overload provoked by chronic pain in breast cancer survivors may not only affect individual cognitive functions, but also have a “Cascade Effect” on other psychological dimensions.
Urban transport during the COVID-19 pandemic: a case study of Poland
Authors: Zajfert Michal 
Published: August 2024

AbstractOngoing improvement in the quality of public transport calms and slows road traffic while causing desirable changes in the transport behaviours of residents and the urban structure of city centres. These efforts were thwarted by the outbreak of the COVID-19 pandemic, which resulted in a significant decrease in public transport ridership. Its scope varied with the passage of time and with the dynamics of the pandemic itself, which were significantly different for individual cities. This article undertakes an analysis of these changes in Poland and identifies factors describing public transport accessibility that may influence them. The novelty of this article is examining the correlation of changes in public transport ridership in 17 Polish cities caused by the COVID-19 pandemic with the presented range of factors and conducted longitudinal studies. A multiple regression analysis was made possible by collecting data describing various aspects of public transport and populations. The introduction of remote work and learning also had a noticeable impact in public transport ridership during this period. In some sectors and fields, they have proven to be at least as efficient, but less expensive than their traditional forms, which suggests that they may have an impact on reducing the public transport ridership after the end of the pandemic.
Unveiling Thermal and Athermal Effects in Strain Hardening Removal of A6061 Aluminum Alloy
Authors: Yu Xiaoming , Gu Shaojie , Wang Guodong , Kimura Yasuhiro , Ju Yang , Toku Yuhki 
Published: August 2024

Abstract
This study explored the application of a high-density pulsed electric current (HDPEC) to mitigate strain hardening in a cold-rolled A6061 aluminum alloy while examining the simultaneous application of HDPEC with furnace heating to reveal the contributions of thermal and athermal effects. The results showed that significant strain-hardening relief was achieved through the HDPEC treatment, particularly at 300 A/mm² for 260 ms, resulting in a 23% reduction in strength and an 86% increase in ductility. Microstructural analysis revealed a shift to fine and equiaxed grains with reduced dislocation density, which was primarily attributed to thermal effects. HDPEC annealing exhibits superior efficiency compared to the conventional annealing treatment, offering cost and time advantages. In addition, this study validated the synergistic impact of HDPEC and furnace heating, with furnace heating supplementing energy requirements, facilitating practical HDPEC implementation. These findings suggest that the HDPEC method and the combined method with conventional heating are promising alternatives for strain-hardening alleviation in A6061 aluminum alloy manufacturing, supporting the development of an eco-friendly and efficient process.

Graphical Abstract
Watt’s Next? Leveraging Process Flexibility for Power Cost Optimization
Authors: Hermann Julia , Rusche Simon , Moder Linda , Weibelzahl Martin 
Published: August 2024

AbstractThe transition from fossil fuels to renewable energy sources poses major challenges for balancing increasingly weather-dependent power supply and demand. Although demand-side energy flexibility, offered particularly by industrial companies, is seen as a promising and necessary approach to address these challenges and realize benefits for companies, its implementation is not yet common practice. Often facing highly complex process landscapes and operational systems, process mining provides significant potential to increase transparency of actual process flows and to discover or reflect existing dependencies and interrelationships of activities, instances or resources. It facilitates the implementation of energy flexibility measures and enables the realization of monetary benefits associated with flexible process operation. This paper contributes to the successful integration of energy flexibility into process operations by presenting a design science research artifact called PM4Flex. This is a prescriptive process monitoring approach that uses linear programming to generate recommendations for pending process flows optimized under fluctuating power prices by utilizing established energy flexibility measures. Thereby, event logs and corresponding company- as well as process-specific constraints are considered. PM4Flex is demonstrated and evaluated based on its implementation as a software prototype, its application to exemplary data from two real-world processes exhibiting power cost savings of up to 75% compared to the original execution, and based on semi-structured expert interviews. PM4Flex provides new design knowledge at the interface of prescriptive process monitoring and the energy domain providing decision support to optimize industrial energy procurement costs.
Circulating miR-122-5p, miR-151a-3p, miR-126-5p and miR-21-5p as potential predictive biomarkers for Metabolic Dysfunction-Associated Steatotic Liver Disease assessment
Authors: Tobaruela-Resola Ana Luz , Milagro Fermín I. , Elorz Mariana , Benito-Boillos Alberto , Herrero José I. , Mogna-Peláez Paola , Tur Josep A. , Martínez J. Alfredo , Abete Itziar , Zulet M. Ángeles 
Published: August 2024

Abstract
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a worldwide leading cause of liver-related associated morbidities and mortality. Currently, there is a lack of reliable non-invasive biomarkers for an accurate of MASLD. Hence, this study aimed to evidence the functional role of miRNAs as potential biomarkers for MASLD assessment. Data from 55 participants with steatosis (MASLD group) and 45 without steatosis (control group) from the Fatty Liver in Obesity (FLiO) Study (NCT03183193) were analyzed. Anthropometrics and body composition, biochemical and inflammatory markers, lifestyle factors and liver status were evaluated. Circulating miRNA levels were measured by RT-PCR. Circulating levels of miR-122-5p, miR-151a-3p, miR-126-5p and miR-21-5p were significantly increased in the MASLD group. These miRNAs were significantly associated with steatosis, liver stiffness and hepatic fat content. Logistic regression analyses revealed that miR-151a-3p or miR-21-5p in combination with leptin showed a significant diagnostic accuracy for liver stiffness obtaining an area under the curve (AUC) of 0.76 as well as miR-151a-3p in combination with glucose for hepatic fat content an AUC of 0.81. The best predictor value for steatosis was obtained by combining miR-126-5p with leptin, presenting an AUC of 0.95. Circulating miRNAs could be used as a non-invasive biomarkers for evaluating steatosis, liver stiffness and hepatic fat content, which are crucial in determining MASLD.

Clinical trial registration
• Trial registration number: NCT03183193 (www.clinicaltrials.gov).
• Date of registration: 12/06/2017.
Agency as an Inherent Property of Living Organisms
Authors: Rosslenbroich Bernd , Kümmell Susanna , Bembé Benjamin 
Published: August 2024

AbstractA central characteristic of living organisms is their agency, that is, their intrinsic activity, both in terms of their basic life processes and their behavior in the environment. This aspect is currently a subject of debate and this article provides an overview of some of the relevant publications on this topic. We develop the argument that agency is immanent in living organisms. There is no life without agency. Even the basic life processes are an intrinsic activity, which we call the organismic level of agency. In addition to this we describe several further levels. These capture different qualities that occur or transform during evolution. In addition to the organismic level, we propose an ontogenetic level, a level of directed agency, directed agency with extended flexibility, and a level that includes the capacities to follow preconceived goals. A further property of organisms is their autonomy. It has been shown that the capacity for autonomy changed during evolution. Here we propose that the two organismic properties autonomy and agency are closely related. Enhanced physiological and behavioral autonomy extends the scope of self-generated, flexible actions and reactions. The increase in autonomy through the evolution of a widened scope of behavioral possibilities and versatility in organisms coincides with extended levels of agency. Especially the human organization, including the sophisticated brain, is the basis for an extended level of agency referring to the capacities to follow preconceived goals. However, it is important for the understanding of the phenomenon of agency not only to assume this latter form, but also to look at the different levels of agency.
The real-world safety profile of tirzepatide: pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database
Authors: Caruso I. , Di Gioia L. , Di Molfetta S. , Caporusso M. , Cignarelli A. , Sorice G. P. , Laviola L. , Giorgino F. 
Published: August 2024

Abstract
Purpose
Randomized controlled trials with tirzepatide (TZP) displayed unprecedented glucose and body weight lowering efficacy in individuals with type 2 diabetes and/or obesity and a safety profile similar to that of glucagon-like peptide-1 receptor agonists (GLP-1RA), mainly characterized by gastrointestinal (GI) adverse events (AE). Concerns on diabetic retinopathy, pancreato-biliary disorders, and medullary thyroid cancer were also addressed. We aimed to investigate whether the same safety issues emerged from the FDA Adverse Event Reporting System (FAERS) post-marketing surveillance database.

Methods
OpenVigil 2.1-MedDRA-v24 and AERSMine (data 2004Q1-2023Q3) were used to query the FAERS database. Reports of GI AE, diabetic retinopathy, pancreato-biliary disorders, and medullary thyroid cancer were investigated. The analysis was then filtered for age, gender, and designation as primary suspect. AE occurrence with TZP was compared to insulin, sodium-glucose cotransporter-2 inhibitors, metformin, and GLP-1RA.

Results
Disproportionate reporting of GI [i.e., nausea (ROR 4.01, 95% CI 3.85–4.19)] and pancreato-biliary disorders [i.e., pancreatitis (ROR 3.63, 95% CI 3.15–4.19)], diabetic retinopathy (ROR 4.14, 95% CI 2.34–7.30), and medullary thyroid cancer (ROR 13.67, 95% CI 4.35–42.96) was detected. TZP exhibited a similar risk of GI AE and medullary thyroid cancer and a lower risk of most pancreato-biliary AE and diabetic retinopathy vs. GLP-1RA.

Conclusions
TZP was associated with an increased risk of specific AE. However, its safety profile was similar to that of GLP-1RA, without increased risk of pancreato-biliary AE, diabetic retinopathy, and medullary thyroid cancer.
Selection of Negative Charged Acidic Polar Additives to Regulate Electric Double Layer for Stable Zinc Ion Battery
Authors: Fan Xing , Chen Lina , Wang Yongjing , Xu Xieyu , Jiao Xingxing , Zhou Peng , Liu Yangyang , Song Zhongxiao , Zhou Jiang 
Published: August 2024

AbstractZinc-ion batteries are promising for large-scale electrochemical energy storage systems, which still suffer from interfacial issues, e.g., hydrogen evolution side reaction (HER), self-corrosion, and uncontrollable dendritic Zn electrodeposition. Although the regulation of electric double layer (EDL) has been verified for interfacial issues, the principle to select the additive as the regulator is still misted. Here, several typical amino acids with different characteristics were examined to reveal the interfacial behaviors in regulated EDL on the Zn anode. Negative charged acidic polarity (NCAP) has been unveiled as the guideline for selecting additive to reconstruct EDL with an inner zincophilic H2O-poor layer and to replace H2O molecules of hydrated Zn2+ with NCAP glutamate. Taking the synergistic effects of EDL regulation, the uncontrollable interface is significantly stabilized from the suppressed HER and anti-self-corrosion with uniform electrodeposition. Consequently, by adding NCAP glutamate, a high average Coulombic efficiency of 99.83% of Zn metal is achieved in Zn|Cu asymmetrical cell for over 2000 cycles, and NH4V4O10|Zn full cell exhibits a high-capacity retention of 82.1% after 3000 cycles at 2 A g−1. Recapitulating, the NCAP principle posted here can quicken the design of trailblazing electrolyte additives for aqueous Zn-based electrochemical energy storage systems.
A modelling study to explore the effects of regional socio-economics on the spreading of epidemics
Authors: Snellman Jan E. , Barrio Rafael A. , Kaski Kimmo K. , Korpi–Lagg Maarit J. 
Published: August 2024

AbstractEpidemics, apart from affecting the health of populations, can have large impacts on their social and economic behavior and subsequently feed back to and influence the spreading of the disease. This calls for systematic investigation which factors affect significantly and either beneficially or adversely the disease spreading and regional socio-economics. Based on our recently developed hybrid agent-based socio-economy and epidemic spreading model we perform extensive exploration of its six-dimensional parameter space of the socio-economic part of the model, namely, the attitudes towards the spread of the pandemic, health and the economic situation for both, the population and government agents who impose regulations. We search for significant patterns from the resulting simulated data using basic classification tools, such as self-organizing maps and principal component analysis, and we monitor different quantities of the model output, such as infection rates, the propagation speed of the epidemic, economic activity, government regulations, and the compliance of population on government restrictions. Out of these, the ones describing the epidemic spreading were resulting in the most distinctive clustering of the data, and they were selected as the basis of the remaining analysis. We relate the found clusters to three distinct types of disease spreading: wave-like, chaotic, and transitional spreading patterns. The most important value parameter contributing to phase changes and the speed of the epidemic was found to be the compliance of the population agents towards the government regulations. We conclude that in compliant populations, the infection rates are significantly lower and the infection spreading is slower, while the population agents’ health and economical attitudes show a weaker effect.