bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paget Disease of the Breast With Invasion From Nipple Skin Into the Dermis: An Unusual Type of Skin Invasion Not Associated With an Adverse Outcome
Authors: Sanders Mary Ann , Dominici Laura , Denison Christine , Golshan Mehra , Wiecorek Tad , Lester Susan C. 
Published: December 2012

Context.—Paget disease is an uncommon skin manifestation of breast cancer, associated with either invasive carcinoma or ductal carcinoma in situ in the underlying breast. In very rare cases, tumor cells within the epidermis invade through the basement membrane of the skin into the dermis.
Objectives.—To identify a series of cases of Paget disease with direct dermal invasion and to investigate the clinicopathologic features and outcome.
Design.—Cases were identified during a 6-year period from the files of 2 hospitals. The clinical histories, imaging studies, and pathology reports were reviewed.
Results.—Seven patients were identified, 5 with microinvasion (&lt;0.1 cm) and 2 with 0.2- or 0.3-cm invasive carcinomas in the dermis. No lymphovascular invasion was seen. Sentinel nodes were negative in 3 patients who underwent biopsy. Five patients were treated with breast conservation with radiation. Three patients were at high risk for breast cancer because of prior breast cancer, Li-Fraumeni syndrome, or radiation for Hodgkin disease. The latter 2 patients underwent bilateral mastectomies. Three patients received hormonal therapy and 1 oophorectomy. No patient received chemotherapy. At follow-ups ranging from 4 to 66 months (median, 20 months), there have been no recurrences.
Conclusions.—Patients with direct dermal invasion from Paget disease had a favorable outcome during the available follow-up period. This type of dermal involvement must be distinguished from locally advanced invasive carcinomas with skin invasion classified as T4b in the American Joint Cancer Commission staging system, as cancers with other types of skin invasion are associated with a poor prognosis.
Multiple Factors Contribute to Positive Results for Hepatitis A Virus Immunoglobulin M Antibody
Authors: Alatoom Adnan , Ansari M. Qasim , Cuthbert Jennifer 
Published: December 2012

Context.—In the United States, a successful vaccination program for hepatitis A virus (HAV) infection has decreased both its incidence and the true positive rate for diagnostic immunoglobulin M (IgM) antibody to HAV in acute hepatitis.
Objective.—To survey positive results of HAV IgM tests and determine the effect of changing ordering options.
Design.—We reviewed all positive results for IgM antibody to HAV between January 2007 and December 2010. Patient demographics, clinical history, and laboratory data were recorded and the encounter, order, and reason for test reviewed. Each result was categorized as indicating acute, recent, resolved, or indeterminate HAV infection.
Results.—A total of 10 735 tests were performed; 35 patients had 49 positive results. Most positive test results were associated with outpatient visits and were ordered in the assessment of patients with liver disease, but not clinical acute hepatitis. In the final analysis, 4 patients had acute hepatitis A and 20 individual patients had recent and/or resolved hepatitis. All but 1 of the remaining 11 patients had another established cause of liver disease with a positive IgM HAV antibody test result; data to determine causality were insufficient. The total number of tests requested annually decreased more than 35% with the introduction of computerized physician order entry.
Conclusions.—Current assays for IgM HAV antibodies are overused in the absence of clinical acute hepatitis; future clinical decision support may improve patterns of order entry. Most patients have findings consistent with HAV exposure but not acute hepatitis; dormant viral infection may be a continuing source of antigen.
Luminescence and Potentiometric Studies on the Complexation of Europium(III) by Picolinate in an Aqueous Solution
Authors: Aoyagi Noboru , Toraishi Takashi , Nagasaki Shinya , Tanaka Satoru 
Published: December 2012

The complexation of Eu3+ aquo ions by picolinic acid in an aqueous solution was investigated to describe the formation of polynuclear complexes that are uncommon for trivalent lanthanides. Potentiometric titration indicated that no polynuclear complexes formed via hydroxide bridges, even at high pH, and that the monomeric form [Eu(Pic)4_(H2O)] was present when a large excess of a picolinate ligand was used. In addition, lifetime analysis of Eu3+ luminescence via time-resolved laser-induced fluorescence spectroscopy was performed under conditions where Eu(pic)2+ appears as the secondary dominant species. Strong quenching of the luminescence was detected, suggesting that polymeric complexes ([Eu(Pic)]m2m+) form, even at low pH, owing to a vicinal Eu-Eu interaction.
In Vivo Rapid Assessment of Compound Exposure (RACE) for Profiling the Pharmacokinetics of Novel Chemical Probes
Authors: McAnally Danielle , Vicchiarelli Michael , Siddiquee Khandaker , Smith Layton H. 
Published: December 2012

AbstractThe Rapid Assessment of Compound Exposure (RACE) assay is an easy and efficient method for estimating the pharmacokinetic parameter of exposure (AUC: area under the curve) of novel chemical probe compounds in mice. RACE is a truncated and compressed version of a traditional comprehensive in vivo pharmacokinetics study. The method uses a single standard formulation, dose, route of administration, and a small cohort of mice (n = 4). Standardized protocols and an abbreviated sample collection scheme reduce the labor needed to perform both the in‐life and bioanalytical phases of the study. The procedure reduces the complexity of data analysis by eliminating all but one calculated pharmacokinetic parameter; estimated exposure (eAUC20‐120), a parameter that is sufficient to rank order compounds based on exposure, but is also easily determined by most software using the simple trapezoidal rule. The RACE assay protocol is readily applicable to early/exploratory studies of most compounds, and is intended to be employed by laboratories with limited expertise in pharmacology and pharmacokinetics. Curr. Protoc. Chem. Biol. 4:299‐309 © 2012 by John Wiley & Sons, Inc.
A High‐Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14
Authors: Lee Byung‐Hoon , Finley Daniel , King Randall W. 
Published: December 2012

AbstractDeubiquitinating enzymes (DUBs) reverse the process of ubiquitination, and number nearly 100 in humans. In principle, DUBs represent promising drug targets, as several of the enzymes have been implicated in human diseases. The isopeptidase activity of DUBs can be selectively inhibited by targeting the catalytic site with drug‐like compounds. Notably, the mammalian 26S proteasome is associated with three major DUBs: RPN11, UCH37, and USP14. Because the ubiquitin ‘chain‐trimming’ activity of USP14 can inhibit proteasome function, inhibitors of USP14 can stimulate proteasomal degradation. We recently established a high‐throughput screening (HTS) method to identify small‐molecule inhibitors specific for USP14. The protocols in this article cover the necessary procedures for preparing assay reagents, performing HTS for USP14 inhibitors, and carrying out post‐HTS analysis. Curr. Protoc. Chem. Biol. 4:311‐330 © 2012 by John Wiley & Sons, Inc.
Quality of Rapeseed Oil Produced by Conditioning Seeds at Modest Temperatures
Authors: Kraljić Klara , Škevin Dubravka , Pospišil Milan , Obranović Marko , Neđeral Sandra , Bosolt Tina 
Published: December 2012

AbstractConditioning rapeseed can significantly increase the amount of bioactive compounds in the crude oil, but if the conditioning temperatures are too high, they can cause unwanted side effects such as darker color and sensory defects. Modest conditioning temperatures may be more suitable, but little is known about the effects on the quality and bioactive composition of the resulting oil. Oil was recovered from five rapeseed cultivars by cold pressing (CP) or by pressing seeds conditioned at 80 °C for 30 min (HP). Conditioning rapeseed increased oil yield without changing fatty acid composition and increased the amount of total sterols by 16 %, total tocopherols by 20 %, and the levels of polyphenols. Levels of the polyphenol canolol were up to 55‐fold higher in HP oil than in CP oil. These higher levels of bioactive compounds gave HP oil higher radical scavenging activity. Although HP oil also had higher free fatty acid contents, peroxide levels, and specific UV extinctions (K values). The quality parameters of HP and CP oils were within codex limits indicating high quality. Modest conditioning temperatures can be used to produce rapeseed oil with high quality and radical scavenging activity.
Mega Sheath Fold of the Mahadevi Hills, Cauvery Suture Zone, Southern India: Implication for Accretionary Tectonics
Authors: Chetty T. R. K. , Yellappa T. , Mohanty D. P. , Nagesh P. , Sivappa V. V. , Santosh M. , Tsunogae T. 
Published: December 2012

Abstract:
The Mahadevi hills, located in the axial zone of Cauvery Suture Zone, comprise a sequence of granulite facies rocks represented by garnet-bearing pyroxene granulites and quartzo-feldspathic gneisess interfolded with banded iron formations. Structural mapping with hand held GPS reveals that the Mahadevi hills constitute a mega sheath fold structure exposing well developed easterly plunging extension lineations. Depressional and culmination surfaces are well demarcated in association with elliptical map patterns. The development of the mega sheath fold structure is genetically related to the regional thrust-nappe tectonics, supporting the model of subduction-accretion-collisional history for the evolution of the Cauvery Suture Zone.
Lipoic acid increases glutamate uptake, glutamine synthetase activity and glutathione content in C6 astrocyte cell line
Authors: Kleinkauf‐Rocha Juliana , Bobermin Larissa Daniele , Machado Priscila de Mattos , Gonçalves Carlos‐Alberto , Gottfried Carmem , Quincozes‐Santos André 
Published: December 2012

AbstractAlpha lipoic acid (LA) is a sulfhydryl compound, used as dietary supplement and to treat a variety of conditions associated to oxidative stress. Glial cells are key modulators of neuroprotection. We show here that LA modulates specific glial parameters in C6 astrocyte cell line, such as glutamate uptake, glutamine synthetase (GS) activity and glutathione content, commonly associated with the protective role of glial cells. LA (10 and 50 μM) after 24 h of treatment significantly decreased the formation of reactive oxygen species (ROS) and nitric oxide (NO) levels, and increased glutamate uptake (up to 20%), GS activity (25%) and GSH content (up to 40%). LA increase glutamate uptake probably by decreasing oxidizing conditions and/or by mechanism dependent of protein kinase C (PKC). In contrast, high concentrations of LA (1000 μM) decreased these glial functions. Moreover, this concentration increased ROS production and NO levels. In summary, these findings show that low doses of LA were able to modulate glial functions and it appears to have remarkable therapeutic potential in neurological diseases involving oxidative stress by improving glutamatergic metabolism.
Altmetric: enriching scholarly content with article‐level discussion and metrics
Authors: ADIE Euan , ROE William 
Published: December 2012

ABSTRACTScholarly content is increasingly being discussed, shared, and bookmarked online by researchers. Altmetric is a start‐up that focuses on tracking, collecting, and measuring this activity on behalf of publishers; here we describe our approach and general philosophy. Over the past year we have seen sharing and discussion activity around approximately 750,000 articles. The average number of articles shared each day grows by 5–10% a month. We look at examples of how people are interacting with papers online and at how publishers can collect and present the resulting data to deliver real value to their authors and readers.
Why serious academic fraud occurs in China
Authors: LIN Songqing 
Published: December 2012

ABSTRACTWhile it is clear that academic papers play an important role in the establishment of status in research a misguided academic evaluation system in China leads some researchers to pursue quantity of papers rather than quality, especially Science Citation Index‐indexed papers. It seems some people do anything to get promotion, even to the point of fabricating academic credentials. In recent years some serious academic fraud has been reported in China. The paper is an attempt to discuss the reasons behind such fraud, which, even though it is rare, nevertheless could potentially destroy academic ethics in China.
The future of learned associations in the humanities
Authors: BENNETT Emma 
Published: December 2012

ABSTRACTThis article is concerned with how six of the largest learned associations in the humanities perceive their own futures and the future of academic publishing, and is based upon informal interviews with representatives of these associations. The outcome of this research indicates that although these organizations are aware of the changing role of learned associations in relation to their members and a wider public, they are struggling to embrace the opportunities represented by the transition to electronic forms of interaction within scholarly communities, and are limited by the lack of funding available in the humanities and an historical commitment to traditional forms of publication and evaluation. In conclusion, this study proposes that the future of learned associations in the humanities is closely linked to the future of academic publishers working in these disciplines.
Self‐citation rates of scientific and technical journals in SCI from China, Japan, India, and Korea
Authors: Hongling FANG 
Published: December 2012

ABSTRACTWe analyze the self‐citation rates of scientific and technical journals in the SCI database from China, Japan, India, and Korea from 2007 to 2009. Korea has the highest self‐citation rate, Japan the lowest. Compared with 2007, the overall level of self‐citation rate declined across all four countries in 2008. In 2009, however, the self‐citation rate of the three countries other than China rose a little. The total cited frequency and impact factor of excessive self‐citing journals and zero self‐citation journal in China, Japan, India, and Korea are all lower than those of the mean of all journals included in the SCI in 2009. It appears that the academic influence of journals whose self‐citation rates is either too low or too high is small.
Marketing OA journals now that authors are customers: the role of RSS
Authors: CHUMBE Santiago , MacLEOD Roddy 
Published: December 2012

ABSTRACTThe article discusses the emergence of authors as consumers with considerable purchasing power in the publishing chain of a new publishing economic model whereby open access (OA) articles are available free of charge to all readers, whilst revenue to cover publication costs comes from authors' fees. Some early evidence suggests that publishers are engaged in competition for the new consumers, and their efforts are shifting from marketing and selling subscriptions, to marketing and selling publishing venues (OA journals). Within this context, the article suggests that RSS is a very important cost‐effective marketing tool if used properly and can play an important role in the marketing and dissemination process of OA articles, in particular when those articles are published in hybrid journals. The article presents real examples of TOC RSS feeds produced by leading publishers and shows that the benefits and effectiveness of those RSS fees are directly related with the availability, quality and richness of its content.
A SURVEY OF TRADE AND WAGE INEQUALITY: ANOMALIES, RESOLUTIONS AND NEW TRENDS
Authors: Kurokawa Yoshinori 
Published: December 2012

AbstractThis paper surveys recent studies on trade and wage inequality. We first introduce some trade‐based explanations for increased wage inequality. There are, however, a number of criticisms of this line of thought based on the ‘trade‐wage inequality anomaly’, the ‘price‐wage anomaly’, and the small volume of trade. Mainly due to these criticisms, trade‐based explanations for rising wage inequality have been limited in the economic literature. Rather, the primary explanations for wage inequality have been based on skill‐biased technological change. Some trade models, however, have weakened the above criticisms, and more economists now argue that the effect of trade, though relatively small compared to that of technological change, is more significant than generally believed. Finally, we attempt to link new trends in inequality, such as job polarization and within‐group inequality, to the trade and wage inequality literature.
A randomized comparison of caudal block by sacral hiatus injection under ultrasound guidance with traditional sacral canal injection in children
Authors: Wang Li‐Zhong , Hu Xiao‐Xia , Zhang Ying‐Fa , Chang Xiang‐Yang 
Published: December 2012

SummaryBackgroundThere is a risk of inadvertent dural or vascular puncture for the traditional single‐shot caudal block performed by inserting the needle into the sacral canal through the sacral hiatus. This prospective, randomized study was to evaluate the clinical feasibility of the hiatus injection under ultrasound guidance for caudal block in children.Methods140 ASA I–II children undergoing inguinal hernia repair were randomly allocated to one of two groups (Group C or Group H, n = 70). 1 ml·kg−1 of 0.25% ropivacaine was injected after the needle was inserted into the sacral canal in Group C, or after the needle pierced the sacrococcygeal ligament under a transverse ultrasound view in Group H. Success rate of block, puncture frequency, complications, and durations of block were recorded.ResultsThe success rate of block was similar between two groups (95.7% in Group C vs 92.8% in Group H, P > 0.05). The first puncture success rate was higher, and the durations of block were shorter in Group H than in Group C (92.8% vs 60% and 145 ± 23s vs 164 ± 31s, respectively P < 0.05). Bloody puncture had an incidence of 18.6% in Group C and 5.7% in Group H (P < 0.05). Subcutaneous bulging occurred in six patients (7.1%) in Group C but none in Group H (P < 0.05).ConclusionsSacral hiatus injection offers a reliable caudal block for pediatric inguinal hernia repair with the advantages of easier performance and fewer complications compared with traditional sacral canal injection.
Effect of rapid fluid resuscitation using crystalloids or colloids on hemostasis in piglets
Authors: Mauch Jacqueline , Madjdpour Caveh , Kutter Annette P. N. , Spielmann Nelly , Bettschart‐Wolfensberger Regula , Weiss Markus , Haas Thorsten 
Published: December 2012

SummaryBackground and ObjectivesImpairment of blood coagulation is one of the main side effects of volume replacement, particularly if artificial colloids such as hydroxyethyl starch (HES) and gelatine preparations are used. This animal study aimed to evaluate the effect of a single fast intravenous crystalloid or colloid fluid bolus on blood coagulation as measured by rotation thromboelastometry (ROTEM®).MethodsThirty‐two anesthetized piglets were infused with a rapid 20 ml·kg−1 fluid bolus of either normal saline (NS), 4% gelatine, 5% albumin or 6% HES 130/0.4 (n = 8 per group) over a period of 2 min. Hemostasis was assessed by ROTEM® before and 1 min after fluid administration. Within‐group differences were analyzed by Wilcoxon test, and additionally overall Kruskal–Wallis test followed by posthoc Mann–Whitney U‐test were applied to detect differences between groups.ResultsAll fluids caused a significant weakening of clot strength within groups. HES and gelatine showed a significantly stronger impairment of clot growth and maximum clot firmness as compared with albumin and normal saline. Impairment of fibrin polymerization was more pronounced following HES as compared with all other fluids.ConclusionAfter moderate but very fast volume loading, HES and gelatine impair blood coagulation to a larger extent as compared with albumin or normal saline, while no significant differences were observed between both artificial colloids.
The Impact of a Statewide Pre-Hospital STEMI Strategy to Bypass Hospitals Without Percutaneous Coronary Intervention Capability on Treatment Times
Authors: Fosbol Emil L. , Granger Christopher B. , Jollis James G. , Monk Lisa , Lin Li , Lytle Barbara L. , Xian Ying , Garvey J. Lee , Mears Greg , Corbett Claire C. , Peterson Eric D. , Glickman Seth W. 
Published: December 2012

Background—
The ultimate treatment goal for ST-segment elevation myocardial infarction (STEMI) is rapid reperfusion via primary percutaneous intervention (PCI). North Carolina has adopted a statewide STEMI referral strategy that advises paramedics to bypass local hospitals and transport STEMI patients directly to a PCI-capable hospital, even if a non-PCI-capable hospital is closer.

Methods and Results—

We assessed the adherence of emergency medical services to this STEMI protocol, as well as subsequent associations with patient treatment times and outcomes by linking data from the Acute Coronary Treatment and Intervention Outcomes Network Registry
®
—Get With the Guidelines
™
and a statewide emergency medical services data system from June 2008 to September 2010 for all patients with STEMI. Patients were divided into those (1) transported directly to a PCI hospital, thereby bypassing a closer non-PCI hospital and (2) first taken to a closer non-PCI center and later transferred to a PCI hospital. Among 6010 patients with STEMI, 1288 were eligible and included in our study cohort. Of these, 826 (64%) were transported directly to a PCI facility, whereas 462 (36%) were first taken to a non-PCI hospital and later transferred. In a multivariable model, increase in differential driving time and cardiac arrest were associated with a lesser likelihood of being taken directly to a PCI center, whereas a history of PCI was associated with a higher likelihood of being taken directly to a PCI center. Patients sent directly to a PCI center were more likely to have times between first medical contact and PCI within guideline recommendations.

Conclusions—
We found that patients who were sent directly to a PCI center had significantly shorter time to reperfusion.