bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parents' views of supermarket fun foods and the question of responsible marketing
Authors: Den Hoed Rebecca C. , Elliott Charlene 
Published: September 2013

PurposeDespite their responsibility for mitigating the influence of commercial culture on children, parents' views of fun food marketing aimed at children remain largely unexplored. This article aims to probe parents' views of supermarket fun foods and the packaging used to promote them to children.Design/methodology/approachIn total 60 in‐depth interviews were conducted with parents from different educational backgrounds, living in three different Canadian cities. Interview responses were analyzed and coded thematically using an iterative process in keeping with grounded theory.FindingsParents generally discussed the promotion of supermarket fun foods to children as either an issue of the nutritional quality of foods promoted to children and/or in light of the communication quality of marketing aimed at children. Parents were also divided along education lines: parents with higher educational backgrounds were more likely to oppose fun foods and praise more pastoral ideals food production and consumption, while those with less education more often praised fun foods.Research limitations/implicationsThese findings cannot be generalized to other parents or parents in other countries. The findings, however, suggest that a more nuanced consideration of differences within and across parents' views is warranted in debates about responsible marketing to children.Originality/valueThis article provides a qualitatively rich snapshot of the views of 60 Canadian parents regarding child‐targeted food marketing, and raises important questions about how to incorporate parents' views into discussions about responsible marketing, rather than presuming they are all of one mindset.
The influence of personality trait and demographics on financial decision making among Generation Y
Authors: Nga Joyce K.H. , Ken Yien Leong 
Published: September 2013

PurposeFinancial planning is important in promoting the social well‐being of a nation. Without proper financial planning, individuals may be ill‐prepared in coping with the escalating cost of living, medical costs as well as enjoying their desired quality of life. However, financial decision making is not always made in a rational manner. This study aims to investigate the influence of personality traits, genders and course majors on decision making dimensions of risk aversion, cognitive biases and socially responsible investing (SRI) criteria among Generation Y undergraduates.Design/methodology/approachThe study utilizes a sample of undergraduates from a business school in Klang Valley, Malaysia. The study adapts the Big 5 personality scales from McCrae and Costa. The scales for the financial decision making dimensions, namely risk aversion, cognitive biases and SRI constructs, were developed for this study based on concepts developed from the extant literature. The validity and reliability of the scales were tested using exploratory factor analysis and Cronbach's alpha respectively. Hypotheses were tested using multiple linear regressions, t‐tests and ANOVA methods.FindingsConscientiousness, openness and agreeableness were found to have a significant influence on risk aversion, cognitive biases and SRI respectively. Gender and course majors taken were not significant in financial decision making.Research limitations/implicationsFuture research should extend this to different cohorts of individuals including working adults and retirees. The mediating influences of personality and moderating influences of demographic factors such as education level, age and religiousity should also be explored to better target potential investors and fulfill their financial goals.Practical implicationsAwareness of the influence of specific personality traits in financial decision making would help financial planners tailor products more effectively to cater for the understanding and lifestyle of the younger generation. There may also be a need in the future for business schools to introduce courses on behavioural finance in their curriculum.Originality/valueStudies on financial planning have more often focused on rational aspects of financial decision making rather than on personality dimensions. This study bridges the gap by investigating the influence of the Big 5 personality traits in financial decision making. The study also posits that the influence of personality traits is more significant than demographic factors in financial decision making.
Relative contribution of foetal and post‐natal nutritional periods on feeding regulation in adult rats
Authors: Martin Agnoux A. , Alexandre‐Gouabau M. ‐C. , Le Dréan G. , Antignac J. ‐P. , Parnet P. 
Published: September 2013

AbstractAimThe aim of this study was to assess the contribution of both foetal and/or post‐natal nutritional periods on feeding regulation in adult rats.MethodsBody weight gain, adipose tissue development, food preferences and feeding pattern under regular chow or Western diets were characterized on four experimental groups of rats: pups born from protein‐restricted dams (R) and weaned by control (RC) or R dams (RR) and pups born from control dams weaned by C (CC) or R dams (CR).ResultsRats born with intrauterine growth restriction (IUGR) and fed a Western diet at adulthood appeared predisposed to body weight gain and more fat accretion, whereas CR rats, despite their preference for high‐fat diet and their hyperphagia for Western diet, did not show significant increase in fat tissue. Daytime food intakes, as well as their speed of ingestion, were found modified in RC and RR. Alterations in the hypothalamic appetite regulatory mechanisms were investigated through neuropeptide expression analysis. IUGR rats showed altered expression of key elements of leptin and NPY signalling, while CR rats exhibited lesser expression of enterostatin, MC4r and HT‐1Br mRNA.ConclusionAltogether, these results indicate that peri‐natal nutrition has different lasting effects on feeding pattern and hypothalamic appetite regulation, depending on the time window insult.
KISS1 expression in colorectal cancer
Authors: Kostakis Ioannis D. , Agrogiannis George , Vaiopoulos Aristeidis G. , Mylona Eleni , Patsouris Efstratios , Kouraklis Gregory , Koutsilieris Michael 
Published: September 2013

Kisspeptins, the products of the KISS1 gene, are involved in cancer invasion, migration, metastasis and angiogenesis, while they induce apoptosis in various cancers. Herein, we studied KISS1 expression in colorectal cancer. We analyzed KISS1 expression using immunohistochemistry and image analysis in normal and malignant tissue samples from 60 patients with colorectal adenocarcinoma. The results correlated with various clinicopathological parameters. The expression of KISS1 was much higher in normal than in malignant colonic mucosa. However, among malignant tissues, KISS1 expression was higher in larger tumors (>4 cm) than in smaller ones (≤4 cm) and in stages III and IV than in stages I and II. In addition, it was higher in patients with lymph node metastases. Moreover, KISS1 levels in the normal mucosa and their difference from those in the malignant mucosa were higher in the right part of the large intestine than in the left one. KISS1 expression is reduced during the malignant transformation of the colonic mucosa and there is a difference in the expression pattern between the right and the left part of the large intestine. However, larger and advanced colorectal tumors express higher KISS1 levels than smaller and localized ones.
Integrated therapy safety management system
Authors: Podtschaske Beatrice , Fuchs Daniela , Friesdorf Wolfgang 
Published: September 2013

AimsThe aim is to demonstrate the benefit of the medico‐ergonomic approach for the redesign of clinical work systems. Based on the six layer model, a concept for an ‘integrated therapy safety management’ is drafted. This concept could serve as a basis to improve resilience.MethodsThe concept is developed through a concept‐based approach. The state of the art of safety and complexity research in human factors and ergonomics forms the basis. The findings are synthesized to a concept for ‘integrated therapy safety management’. The concept is applied by way of example for the ‘medication process’ to demonstrate its practical implementation.ResultsThe ‘integrated therapy safety management’ is drafted in accordance with the six layer model. This model supports a detailed description of specific work tasks, the corresponding responsibilities and related workflows at different layers by using the concept of ‘bridge managers’. ‘Bridge managers’ anticipate potential errors and monitor the controlled system continuously. If disruptions or disturbances occur, they respond with corrective actions which ensure that no harm results and they initiate preventive measures for future procedures. The concept demonstrates that in a complex work system, the human factor is the key element and final authority to cope with the residual complexity. The expertise of the ‘bridge managers’ and the recursive hierarchical structure results in highly adaptive clinical work systems and increases their resilience.ConclusionsThe medico‐ergonomic approach is a highly promising way of coping with two complexities. It offers a systematic framework for comprehensive analyses of clinical work systems and promotes interdisciplinary collaboration.
Deformations of amygdala morphology in familial pediatric bipolar disorder
Authors: Kelley Ryan , Chang Kiki D , Garrett Amy , Alegría Dylan , Thompson Paul , Howe Meghan , L Reiss Allan 
Published: September 2013

ObjectiveSmaller amygdalar volumes have been consistently observed in pediatric bipolar disorder subjects compared to healthy control subjects. Whether smaller amygdalar volume is a consequence or antecedent of the first episode of mania is not known. Additionally, smaller volume has not been localized to specific amygdala subregions.MethodsWe compared surface contour maps of the amygdala between 22 youths at high risk for bipolar disorder, 26 youths meeting full diagnostic criteria for pediatric familial bipolar disorder, and 24 healthy control subjects matched for age, gender, and intelligence quotient. Amygdalae were manually delineated on three‐dimensional spoiled gradient echo images by a blinded rater using established tracing protocols. Statistical surface mesh modeling algorithms supported by permutation statistics were used to identify regional surface differences between the groups.ResultsWhen compared to high‐risk subjects and controls, youth with bipolar disorder showed surface deformations in specific amygdalar subregions, suggesting smaller volume of the basolateral nuclei. The high‐risk subjects did not differ from controls in any subregion.ConclusionsThese findings support previous reports of smaller amygdala volume in pediatric bipolar disorder and map the location of abnormality to specific amygdala subregions. These subregions have been associated with fear conditioning and emotion‐enhanced memory. The absence of amygdala size abnormalities in youth at high risk for bipolar disorder suggests that reductions might occur after the onset of mania.
Therapeutic approaches to haematological malignancies in adolescents and young adults
Authors: Place Andrew E. , Frederick Natasha N. , Sallan Stephen E. 
Published: September 2013

SummaryTremendous strides have been made in improving the outcomes of haematological malignancies (HM) over the last three decades, but adolescents and young adult (AYA) patients have not benefitted equally compared to younger and older patients. Excellent outcomes in Hodgkin lymphoma have allowed tailoring of highly effective regimens that limit the incidence of late effects. Early successes in paediatric acute lymphoblastic leukaemia set the stage for a series of studies in young adults utilizing a paediatric‐type treatment strategy. These studies have determined that AYAs benefit from paediatric‐type chemotherapy regimens. Despite the increased incidence of acute myeloid leukaemia and non‐Hodgkin lymphoma in the AYA age group, optimal strategies for these patients have not been systematically pursued. There is renewed interest in improving HM outcomes in AYA patients and this will rely on the development of clinical trials that specifically target these patients. Understanding and addressing the unique psychosocial challenges of this population will be critical in supporting this endeavor.
Renal allograft outcomes following early corticosteroid withdrawal in Hispanic transplant recipients
Authors: Afaneh Cheguevara , Cheng Elaine , Aull Meredith J. , Watkins Anthony C. , Kim Jim , Leeser David B. , Kapur Sandip 
Published: September 2013

AbstractBackgroundRenal transplant outcomes in Hispanics have been conflicting regarding acute rejection (AR) and allograft survival. Additionally, the feasibility of early corticosteroid withdrawal (ECW) regimens among Hispanics has not been adequately addressed. The purpose of this study is to report outcomes following ECW among Hispanic renal transplant recipients.MethodsWe retrospectively reviewed 498 consecutive renal transplants performed at our institution between July 2005 and October 2007, including 73 Hispanic and 146 white recipients who had ECW (median follow‐up 49 months). Demographics, transplant data, and outcomes of Hispanic and white recipients (WR) were analyzed.ResultsHispanics had a higher incidence of diabetes mellitus and hypertension (p = 0.007), a higher proportion of blood type O (p = 0.006), and a higher serum panel reactive antibody at the time of transplantation (p = 0.02) compared with WR. Additionally, Hispanics were on dialysis longer than WR prior to transplantation (p = 0.03). Nevertheless, the incidence of AR, patient, and graft survival rates was similar (p > 0.05) between Hispanics and WR. Ethnicity was not an independent predictor of inferior patient and graft outcomes in multivariate analyses.ConclusionOur single‐center experience indicates that ECW can be performed in Hispanic renal transplant recipients, with patient and allograft outcomes comparable with those observed in WR.
Wound events in kidney transplant patients receiving de novo everolimus: a pooled analysis of three randomized controlled trials
Authors: Cooper M. , Wiseman A. C. , Zibari G. , McCague K. , Kim Y. , Geissler F. , Nashan B. 
Published: September 2013

AbstractData were pooled from three prospective, multicenter trials in which 1996 de novo kidney transplant recipients were randomized to everolimus 1.5 or 3.0 mg or mycophenolic acid (MPA), with cyclosporine and steroids. Wound healing complications reported as adverse events were retrospectively reviewed in a blinded manner. The incidence of wound healing adverse events was 17.6% (351 of 1996) by day 90 and was similar for everolimus 1.5 mg (16.6% [110 of 661]) vs. MPA (14.3% [95 of 665]) (p = 0.255), but higher with everolimus 3.0 mg (21.8% [146 of 670]) (p < 0.001 vs. MPA). Similar results were observed for wound healing complications reported as serious adverse events. The 12‐month incidence of lymphocele was 11.2% with everolimus 1.5 mg and 8.9% with MPA (p = 0.171), but lymphocele reported as a serious adverse event were more frequent with everolimus 1.5 mg (6.5% vs. 3.5%; p = 0.012). The hazard ratio (HR) for any wound healing complication vs. MPA was not significantly higher for everolimus <3 ng/mL (HR 1.33; 95% CI 0.94–1.88; p = 0.104), but increased to 1.46 (95% CI 1.12–1.90; p = 0.005) for 3–8 ng/mL and 1.69 (95% CI 1.20–2.38; p = 0.002) for >8 ng/mL. These results suggest that de novo kidney transplant patients receiving an initial everolimus dose of 1.5 mg do not appear to have a pronounced increased risk of wound healing complications vs. patients receiving MPA.
Echocardiographic Sizing of the Left Atrium of the Transplanted Heart
Authors: Batal Omar , Brumberg Howard , Teuteberg Jeffrey J. , Katz William E. 
Published: September 2013

BackgroundThe left atrium (LA) in the transplanted heart (TH) is a surgically created chamber from variable portions of donor and recipient LA. The American Society of Echocardiography (ASE) recommends measuring LA size in native hearts using biplane LA volume index (LAVI) as a more accurate measurement than LA anterior‐posterior diameter (LA‐APD). We hypothesized that LA‐APD underestimates LA size when compared with LAVI in the TH.MethodsPatients with a TH from 1/05 to 1/10 who had a transthoracic echocardiogram within 24 months of transplant were studied. Patients were excluded if they had an ejection fraction <50%, left ventricular hypertrophy, >mild aortic or mitral regurgitation, or poor image quality. Echocardiograms were analyzed for LA‐APD and LAVI. LA size was classified as normal, mild, moderate, or severely enlarged based on age and sex specific cutoffs per the ASE.ResultsOf 297 patients evaluated, 160 met inclusion criteria. Mean age was 57 ± 13 years and 79% were males. Mean LA‐APD and LAVI were 4.3 ± 0.6 cm and 36 ± 14 mL/m2, respectively. LAVI correlated with LA‐APD (r = 0.43, R2 = 0.18, P < 0.0001). By LA‐APD measurement, 20 (13%) LA were classified as having moderate or severe LA enlargement versus 80 (50%) by LAVI, P = 0.001. LA size was underclassified by ≥2 classes in 44 (28%) by LA‐APD versus LAVI.ConclusionsIn the setting of cardiac transplant, the LA size classified by LA‐APD is commonly less than that classified by LAVI.
Doppler‐Derived Left Ventricular Negative dP/dt as a Predictor of Atrial Fibrillation or Ischemic Stroke in Patients with Degenerative Mitral Regurgitation and Normal Ejection Fraction
Authors: Yi Jeong‐Eun , Lee Dong‐Hyeon , Cho Eun Joo , Jeon Hui‐Kyung , Jung Hae‐Ok , Youn Ho‐Joong 
Published: September 2013

IntroductionThe aim of this study was to investigate the role of Doppler‐derived left ventricular (LV) −dP/dt in predicting atrial fibrillation (AF) or ischemic stroke in patients with moderate to severe degenerative mitral regurgitation (MR).MethodsDoppler‐derived LV −dP/dt was determined from the continuous‐wave Doppler spectrum of the MR jet (−dP/dt = 32/time between 3 and 1 m/sec) in 80 patients (mean age 59 ± 16 years, 41% men) with moderate to severe degenerative MR, normal LV ejection fraction (LVEF ≥ 60%), and sinus rhythm at diagnosis. Events were defined as new AF or ischemic stroke.ResultsDuring a mean follow‐up of 18 ± 13 months, there were 9 events (6 new AF, 3 ischemic strokes). Univariate analysis showed that older age, decreased LV −dP/dt, increased LV mass index, and left atrial volume index (LAVI), shortened deceleration time (DT), reduced A′ velocity, and elevated E/E′ ratio, prolongation of pulmonary venous (PV) atrial reversal (AR) flow duration relative to mitral inflow A‐wave duration (AR‐Adur) were associated with events. In multivariate Cox regression analysis, Doppler‐derived LV −dP/dt (for each 100 mmHg/sec increase, hazard ratio: 0.165, 95% confidence interval: 0.036–0.761, P = 0.021) and E/E′ (hazard ratio: 0.820, 95% confidence interval: 0.682–0.987, P = 0.036) were significant independent predictors of AF or ischemic stroke.ConclusionsDoppler‐derived LV −dP/dt is independently associated with the occurrence of AF or ischemic stroke in patients with moderate to severe degenerative MR and provides additional prognostic information.
Rethinking length‐based fisheries regulations: the value of protecting old and large fish with harvest slots
Authors: Gwinn Daniel C , Allen Micheal S , Johnston Fiona D , Brown Paul , Todd Charles R , Arlinghaus Robert 
Published: September 2013

AbstractManaging fisheries using length‐based harvest regulations is common, but such policies often create trade‐offs among conservation (e.g. maintaining natural age‐structure or spawning stock biomass) and fishery objectives (e.g. maximizing yield or harvest numbers). By focusing harvest on the larger (older) fish, minimum‐length limits are thought to maximize biomass yield, but at the potential cost of severe age and size truncation at high fishing mortality. Harvest‐slot‐length limits (harvest slots) restrict harvest to intermediate lengths (ages), which may contribute to maintaining high harvest numbers and a more natural age‐structure. However, an evaluation of minimum‐length limits vs. harvest slots for jointly meeting fisheries and conservation objectives across a range of fish life‐history strategies is currently lacking. We present a general age‐ and size‐structured population model calibrated to several recreationally important fish species. Harvest slots and minimum‐length limits were both effective at compromising between yield, numbers harvested and catch of trophy fish while conserving reproductive biomass. However, harvest slots consistently produced greater numbers of fish harvested and greater catches of trophy fish while conserving reproductive biomass and a more natural population age‐structure. Additionally, harvest slots resulted in less waste in the presence of hooking mortality. Our results held across a range of exploitation rates, life‐history strategies and fisheries objectives. Overall, we found harvest slots to represent a valuable option to meet both conservation and recreational fisheries objectives. Given the ubiquitous benefits of harvest slots across all life histories modelled, rethinking the widespread use of minimum‐length limits is warranted.
Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for Helicobacter pylori Infection after Failure of Sequential Therapy
Authors: Hsu Ping‐I , Chen Wen‐Chi , Tsay Feng‐Woei , Shih Chih‐An , Kao Sung‐Shuo , Wang Huay‐Min , Yu Hsien‐Chung , Lai Kwok‐Hung , Tseng Hui‐Hwa , Peng Nan‐Jing , Chen Angela , Kuo Chao‐Hung , Wu Deng‐Chyang ,   Taiwan Acid‐Related Disease (TARD) Study Group
Published: September 2013

AbstractBackgroundSequential therapy has been recommended in the Maastricht IV/Florence Consensus Report as the first‐line treatment for Helicobacter pylori eradication in regions with high clarithromycin resistance. However, it fails in 5–24% of infected subjects, and the recommended levofloxacin‐containing triple rescue therapy only achieves a 77% eradication rate after failure of sequential therapy.AimTo investigate the efficacy of a novel quadruple therapy comprising proton‐pump inhibitor, bismuth, tetracycline, and levofloxacin for rescue treatment of sequential therapy.MethodsThis was a multicenter study in which H. pylori‐infected patients who had failed sequential therapy received a 10‐day quadruple therapy (esomeprazole (40 mg b.d), tripotassium dicitrato bismuthate (120 mg q.d.s.), tetracycline (500 mg q.d.s.), and levofloxacin (500 mg o.d.) for 10 days). H. pylori status was examined 6 weeks after the end of treatment.ResultsFrom July 2007 to June 2012, twenty‐four subjects received 10‐day quadruple therapy. The eradication rates according to intention‐to‐treat and per‐protocol analyses were both 95.8% (23 of 24; 95% confidence interval, 87.8–103.8%). Adverse events were seen in 25.0% (6 of 24) of the patients. Drug compliance was 100.0% (24/24).ConclusionsThe 10‐day quadruple therapy comprising proton‐pump inhibitor, bismuth, tetracycline, and levofloxacin achieves a very high eradication rate for H. pylori infection after failure of sequential therapy. It is well tolerated and has great potential to become a good choice of rescue treatment following non‐bismuth‐containing quadruple therapy in regions with high clarithromycin resistance.