bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Topics in Diagnosis and Treatment of Tinea Unguium in Japan
Authors: Tanuma Hiroyuki 
Published: April 2015

AbstractThe number of patients with tinea unguium accounts for 0.5% to 2% of the total number of outpatients in Japan.The diagnosis of tinea unguium can be relatively easily made on the basis of clinical symptoms and direct microscopic findings. However onychomycosis due to fungi other than dermatophytes should always be suspected if no dermatophytes are cultured despite positive findings in direct microscopy. In such cases, it is necessary to repeat cultures and conduct histopathological evaluation using PAS‐staining technique or enzyme antibody technique. At present, oral administration of griseofulvin and terbinafine are the treatments covered by health insurance in Japan. In the future, however, other orally active antifungal drugs such as itraconazole and fluconazole will become available for use by in‐patients who do not respond to griseofulvin. It is essential to patiently continue treatment even if oral therapy is impossible, because other therapies such as ODT therapy using topical antifugal agents and urea ointment or abrading affected nails as much as possible with a file or dental drill may be effective without oral therapy.
Genital Angiofibromas in Tuberous Sclerosis: Two Cases
Authors: Nico Marcello Menta Simonsen , Ito Luci Mari , Valente Neusa Yuriko Sakai 
Published: April 2015

AbstractCutaneous lesions are an important feature of tuberous sclerosis (TS). Facial angiofibromas usually begin to appear at the end of the first decade of life and are considered to occur in about 88% of adults with TS. They are only rarely reported on sites other than the face or front. In this paper, we report two patients with the complete syndrome of TS that had, in addition to classic facial lesions, multiple papules on the genital area. Histopathology confirmed the diagnosis of angiofibroma. One patient's lesions were misdiagnosed as genital warts and were so being treated before the correct diagnosis was made. Although we don't know the incidence of genital angiofibromas in TS patients, we believe that they might be underreported, because dermatologists generally don't look for them when they see these patients.
Giant Nevus Lipomatosus Cutaneus Superficials: Case Report and Review of the Literature
Authors: Bergonse Fabiane N. , Cymbalista Natalia C. , Nico Marcello Menta S. , Santi Cláudia G. , Golcman Benjamin , Golcman Ronaldo , Sotto Miriam N. 
Published: April 2015

AbstractNevus lipomatosus superficialis is a rare disorder characterized by a nevoid fatty growth within the papillary and reticular dermis. Lesions more often occur in the sacral, abdominal, or pelvic regions. A 36‐year‐old Brazilian female with giant nevus lipomatosus is reported. Our case seems to be the biggest reported in the literature.
Angiolymphoid Hyperplasia with Eosinophilia Showing Characteristics of Kimura's Disease
Authors: Chung Tae‐Suk , Kim Dong‐Kun , Yoon Moon‐Soo , Yang Woo‐Ick 
Published: April 2015

AbstractAngiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign condition affecting principally the head and neck region of young females. We describe a 42‐year‐old female patient of ALHE showing the typical changes of endothelial cells and features similar to Kimura's disease in histologic and immunohistochemical findings.
Large Annular Purpura and Paraneoplastic Purpura in a Patient with Sjögren's Syndrome and Cervical Cancer
Authors: Nakajima Hideki , Ikeda Mitsunori , Yamamoto Yasuo , Kodama Hajime 
Published: April 2015

AbstractWe report a 79‐year‐old female with anaphylactoid purpura on her legs and unusual large annular purpura on the trunk. Histopathological characteristics of leukocytoclastic vasculitis were observed in the upper and middle dermis of both types of skin lesions. She was complicated by Sjögren's syndrome and advanced cervical cancer. The annular purpura spontaneously resolved in a week and did not recur. However, the anaphylactoid purpura relapsed more frequently and spread more widely following the elevation of her serum SCC antigen levels from the onset of purpura until her death. We consider that the characteristic annular configuration was caused by the complication of Sjögren's syndrome and that the recurrent anaphylactoid purpura indicated paraneoplastic vasculitis primarily caused by the tumor specific protein immune complexes. Complication by Sjögren's syndrome many also play a role in the development of allergic vasculitis.
Lichen Planus with Involvement of All Twenty Nails and the Oral Mucous Membrane
Authors: Takeuchi Yoshio , Iwase Nanae , Suzuki Mari , Tsuyuki Shigeaki 
Published: April 2015

AbstractA 57‐year‐old man had had deformities of all ten fingernails for one and a half years before presentation and deformities of all ten toenails for the previous six months. The surfaces of the nails were rough, with excessive longitudinal striations. The bases of the nails were slightly hypertrophic, and the tips were atrophic and itchy. A longitudinal nail biopsy including the nail matrix revealed the typical histology of lichen planus. Reticulated pigmentation, maceration, and erosion on the buccal mucous membrane were also discovered. Histological analysis of the buccal mucous membrane revealed lichen planus intermingled with eosinophils. Immunological blood analysis revealed elevated CD4+ T cells and CD4/CD8 ratio. He worked as a tinsmith and had dental metal. The metal series patch test revealed positive reactions to chromate and tin. Treatment with systemic steroids was quite effective in treating the nail lesions.
Primary Pachydermoperiostosis: A Case Report
Authors: Thappa Devinder Mohan , Sethuraman Gomathy , Kumar G. Ravindra , Elangovan S. 
Published: April 2015

AbstractPachydermoperiostosis (PDP), a rare genodermatosis, occurred in a 38‐year‐old Indian male. He presented with progressive thickening of the skin on the face and scalp of 15 years duration. Widening of his wrists and ankles and broadening of the fingers and toes had also developed since then. He was born of a consanguineous marriage and had no family history of a similar disorder. He had the typical findings of complete form of PDP including cutis verticis gyrata, coarse facial features, clubbing of the digits in the skin, and periostosis and cortical thickening at the distal ends of long bones of the extremities and small bones of the hands and feet. PDP has two different forms—primary and secondary. These two entities are differentiated by family history and presence or absence of a primary lesion, usually in the lungs. Clinically, in secondary PDP, the cutaneous findings (pachydermia, seborrhoea, oiliness) are less severe than primary PDP; osteoarthropathy is more severe and painful in secondary PDP, especially with congenital heart disease. The present case was suffering from primary PDP that had expressed itself in its complete form.
Complete Remission of Hypereosinophilic Syndrome after Interferon‐α Therapy: Report of a Case and Literature Review
Authors: Yoon Tae‐Young , Ahn Gwang‐Bum , Chang Seung‐Ho 
Published: April 2015

AbstractHypereosinophilic syndrome (HES) is a multisystem disease with a significant mortality rate. It is characterized by peripheral blood eosinophilia and infiltration of eosinophils into many organs including skin. We describe a patient with cutaneous, pulmonary, and gastric symptoms of HES. He was first treated with systemic and topical corticosteroids, antihistamines, and photochemotherapy. Therapy was switched to interferon‐α, because we had to consider side effects of corticosteroids and no significant improvement had been achieved. During the period of usage of interferon‐α for 50 weeks, his symptoms of HES nearly cleared. There has been no recurrence in the eight months since the discontinuation of interferon‐α therapy.
Tinea Capitis: Current Concepts
Authors: Čeburkovas Olegas , Schwartz Robert A. , Janniger Camila K. 
Published: April 2015

AbstractTinea capitis is an important fungal infection that may at times be a clinical, diagnostic and therapeutic challenge. It is common in childhood around the world, becoming almost epidemic in some communities. The central European and American experience with it is somewhat variable, due to different etiologic fungi. The use of topical antifungal agents and other approaches is stressed as of value alongside the use of systemic antifungal medication.
Pityriasis Rubra Pilaris (PRP): Report of Four Cases
Authors: Sehgal Virendra N. , Bajaj Pramila , Jain Sanjeev 
Published: April 2015

AbstractFour patients with pityriasis rubra pilaris are reported. The diagnosis in each was based upon well‐recognized clinical features. Two of them, a mother and son, had the disease since childhood and were marked by relative remission in spring and exacerbation in autumn. Moderate to severe pruritus was a common dominator. Erythroderma was a presenting feature in one case. Although histopathology was considered imperative, it only supplemented the clinical expression. Vitamin A in heavy dosage, supplemented by vitamin E and stanozolol in tandem, was the mainstay of treatment.
A Case of Erythromelalgia Successfully Controlled by Systemic Steroids and Pentazocine—Is It Related to a Unique Subtype of Neutrophilic Dermatosis?
Authors: Suh Dae Hun , Kim Sang Duck , Ahn Jong Seong , Han Kwang Ho , Cho Kwang Hyun , Eun Hee Chul , Youn Jai Il 
Published: April 2015

AbstractErythromelalgia is a rare cutaneous disorder characterized by erythema, burning discomfort, and warmth of the extremities. Its form may be adult‐ or early‐onset, and it may be further classified as idiopathic or secondary. Its pathogenesis and histopathologic findings have not yet been clearly defined. Various treatment modalities have been tried, but, for the idiopathic type, none has been successful.We present a case of adult‐onset idiopathic erythromelalgia with unusual histopathological findings which showed a remarkable response to corticosteroids and pentazocine.
Cassiopeia Flap: Modification of Limberg Flap for Saving Normal Skin
Authors: Mizutani Hitoshi , Isoda Ken‐ichi , Asahi Kunihiko , Yamanaka Keichi , Shimizu Masayuki 
Published: April 2015

AbstractLocal flaps have the advantages of texture matching and increased flap survival rate. The proper local flap planning for each lesion causes the dermatologist to be reluctant to employ them. We propose a modified local flap, the “Cassiopeia flap”, with three simple marking points made on the ends of the diameter and on the equidistant point along the diameter; two points from equilateral triangles form a “W (Cassiopeia)”. We applied this modification to ten lesions on the face, scalp, trunk and thigh with excellent results.
A Case of Combined Nevus: Compound Nevus and Spindle Cell Spitz Nevus
Authors: Jin Zhao‐hui , Kumakiri Masanobu , Ishida Hisaya , Kinebuchi Shoichi 
Published: April 2015

AbstractCombined nevi consisting of a Spitz nevus and an acquired nevus are unusual, and, to our knowledge, the combination of a spindle cell Spitz nevus and an overlying compound nevus has not been previously reported. We report a 17‐year‐old girl with a nodule on the left anterior lower extremity. The nodule was asymptomatic, firm, brown, symmetrical, dome‐shaped, 8 mm in diameter, and not found with ulceration. Histological findings showed proliferation of spindle‐shaped cells with an overlying compound nevus. The spindle‐shaped cells were large, non‐pigmented, uniform in size and shape, with rare mitoses and without nuclear atypia, and arranged in a storiform pattern in thick collagen bundles. They stained positively for S‐100 and negatively for HMB‐45. The lesion was considered to be a new type of combined nevus consisting of a spindle cell Spitz nevus and an overlying compound nevus.
Analysis of T‐Cell Antigen Receptor γ Chain Gene Rearrangement by Polymerase Chain Reaction in Combination with Denaturing Gradient Gel Electrophoresis in the Differential Diagnosis of Cutaneous T‐Lymphoproliferative Diseases
Authors: Nagasawa Tomohiko , Nakatsuka Shin‐ichi , Miwa Hideaki , Kanno Hiroyuki , Itami Satoshi , Yoshikawa Kunihiko , Aozasa Katsuyuki 
Published: April 2015

AbstractA polymerase chain reaction (PCR)‐based strategy has been developed for analysis of clonal rearrangement of the T‐cell receptor γ gene (TCRγ) and was shown to be useful for detection of clonal T‐cell populations. In this study, we performed PCR combined with denaturing gradient gel electrophoresis (DGGE) on fresh frozen biopsy samples from 16 patients with cutaneous T‐lymphproliferative diseases in whom a definite diagnosis was difficult to make on morphological and immunohistochemical grounds alone. Ages of the patients at biopsy ranged from 28 to 81 (median 62) years, and the subjects consisted of 8 men and 8 women. They presented with erythema on the extremities in 5 cases, trunk in 7, buttock in 2, and papules on the trunk and face in one case each. Clonal rearrangement of TCRγ was observed in 3 of 16 cases. Clinical diagnoses of these three cases were mycosis fungoides, cutaneous invasion of adult T‐cell leukemia (ATL), and large granular lymphocytic leukemia (LGL) of T‐cell type, respectively, but they were histologically difficult to differentiate from reactive cutaneous T‐cell proliferation. The skin lesions of the LGL case worsened, and this patient died two years after biopsy. Another patient with suspected mycosis fungoides in the plaque stage died due to dissemination of tumors 22 months after biopsy. The remaining one patient with ATL survived with cutaneous lesions for over four years. Clonality was not demonstrated in the remaining 13 cases, and their clinical courses were favorable. These findings showed that demonstration of clonal TCRγ gene rearrangement using the PCR‐DGGE method is very helpful for diagnosis of cutaneous T‐cell neoplasms.
Hyalinizing Spitz Nevus
Authors: Lee Mi‐Woo , Choi Jee‐Ho , Sung Kyung‐Jeh , Moon Kee‐Chan , Koh Jai‐Kyoung 
Published: April 2015

AbstractA seventeen‐year‐old Korean girl had a reddish‐brown papular lesion on the nose. Histopathologically, it proved to be a “hyalinizing Spitz nevus” with the characteristic features of a discohesive growth pattern of nevus cells and hyalinized stroma. Immunohistochemical stains showed positive reactivity of nevus cells with S‐100 protein and Vimentin and negative stainings with HMB45, CD68, CEA and low molecular weight cytokeratin. Hyalinizing Spitz nevus may represent a variant in the spectrum of Spitz nevus.
A Case of Pseudogout
Authors: Usuki Kazunari , Yamashita Miki , Kanzaki Tamotsu 
Published: April 2015

AbstractWe report a 56‐year‐old Japanese male with a gout‐like acute attack of synovitis and panniculitis in his right wrist without hyperuricemia. Calcium pyrophosphate dihydrate (CPPD) crystals were found in the synovial fluid of the affected joint. A diagnosis of pseudogout was made. The attack subsided two days after medication with 30 mg of predonisolon. Although this is a relatively common disease in elderly people, we rarely encounter such case reports in dermatological journals.
Pedunculated Lipofibroma
Authors: Öztürkcan Serap , Terzioğlu Ahmet , Akyol Melih , Altinor Savaş , Yildiz Esin 
Published: April 2015

AbstractPedunculated lipofibroma is a relatively rare form of nevus lipomatosus superficialis. The lesions are large, slow growing, pedunculated tumors. Histologically, groups and strands of fat cells are found embedded among the collagen bundles of the dermis. We presented a woman diagnosed with a pedunculated lipofibroma clinically and histopathologically.
Kangal Hot Spring with Fish and Psoriais Treatment
Authors: Özçelik Sedat , Polat H. Hüseyin , Akyol Melih , Yalçin A. Nevzat , Özçelik Derviş , Marufihah Mehmet 
Published: April 2015

AbstractThe effect of “Kangal Hot Spring with Fish” in the treatment of psoriasis is investigated. The study was carried out on 87 patients with psoriasis vulgaris and the patients were evaluated by a dermatologist for 21 days. The evaluation of the disease was performed using PASI (Psoriasis Area and Severity Index) scores. Recurrences were investigated in the patient population, who had been previously treated in the same hot spring. The first examination scores were significantly higher than the scores of the 3, 6, 9, 12, 15 and 21 days after treatment (p<0.01). Longer remission periods, when compared to the topical corticosteroid treatment, expressed by the 35 patients previously treated in hot spring (p<0.01). Spa therapy under observation of a dermatologist may be effective and useful for psoriasis vulgaris patients.
A Case of Toxic Epidermal Necrolysis‐Type Drug Eruption Induced by Oral Lysozyme Chloride
Authors: Kobayashi Miwa , Yamamoto Osamu , Yasuda Hiroshi , Asahi Masakazu 
Published: April 2015

AbstractWe report a case of toxic epidermal necrolysis‐type drug eruption. A 23‐year‐old man took an oral over‐the‐counter preparation for the common cold. A few days later, generalized erythema developed with systemic malaise and pain. A multiple blister formation followed, and Nikolsky's sign was noted on each blister. A lymphocyte stimulation test (LST) with the patient's peripheral lymphocytes strongly suggested that the eruption was attributable to lysozyme chloride which was included in the preparation taken. Follwing an intravenous drip of betamethasone for two weeks, the eruptions improved favorably.
Transplant of Cultured Autologous Pure Melanocytes after Laser‐Abrasion for the Treatment of Segmental Vitiligo
Authors: Chen Yu‐Fu , Chang Jeffrey S. , Yang Pey‐Yuh , Hung Chih‐Ming , Huang Min‐Ho , Hu Dan‐Ning 
Published: April 2015

AbstractSegmental vitiligo is a special type of vitiligo with unilateral distribution of lesions and has a stable course. Clinically, many patients with segmental vitiligo have unsatisfactory responses to topical corticosteroid or UV phototherapy. We have developed a technique for the isolation of melanocytes from a small specimen of normally pigmented skin obtained via a suction blister. The melanocytes can be proliferated in culture and then replanted onto laser‐abrased vitiliginous areas. We used this procedure to treat 25 patients with segmental vitiligo that were refractory to medical therapy. The repigmented portion of the total treated area amounted to 95–100% in 21 patients and 65 to 94% in 4 patients. The response rate to treatment was 100% in this study. No scarring or other side‐effects developed. The results of this study demonstrate that this method is a valuable tool for the treatment of patients with segmental vitiligo.
A Case of Acute Graft‐versus‐Host Disease Following Autologous Peripheral Blood Stem Cell Transplantation
Authors: Tokime Kazuya , Isoda Ken‐ichi , Yamanaka Kei‐ichi , Mizutani Hitoshi 
Published: April 2015

AbstractA 42–year‐old woman developed severe erythema with exfoliative scaling on the bilateral palms and soles and erosive dermatitis on the axillae and groin eight days after an autologous peripheral blood stem cell transplantation for the treatment of non‐Hodgkin's lymphoma. She also developed exanthema; however she did not show intestinal, hepatic, or renal involvement. The skin biopsy revealed characteristic apoptotic cell death of the epidermis with eosinophilic necrosis, and she was diagnosed with acute graft‐versus‐host disease (GVHD). The cutaneous lesions responded to topical corticosteroid treatments and improved within a month without systemic immunosuppressing therapies. The cutaneous GVH reaction did not recur. However, she was treated with an intermittent thrombocyte transfusion because of persistent thrombocytopenia. On day 130, she developed intestinal pneumonia and died due to respiratory dysfunction. Unlike an allo‐bone marrow graft, GVHD after an autologous stem cell transplantation is not common. Even for an autologous transplantation, GVH may develop with less characteristic clinical manifestations.
Electron Microscopic Study of Langerhans Cell Histiocytosis
Authors: Kobayashi Miwa , Yamamoto Osamu , Suenaga Yoshinori , Asahi Masakazu 
Published: April 2015

AbstractAmong the several forms of Langerhans cell histiocytosis (LCH), Letterer‐Siwe disease is the most acute disseminated multisystemic variant. The course of Letterer‐Siwe disease is usually rapid and fatal. We report here a cases of Letterer‐Siwe disease which showed a good response to chemotherapy. We also describe the unusual ultrastructural findings in the histiocyte‐like cells in this case.
A Case of Mycosis Fungoides after CD30 Positive Anaplastic Large Cell Lymphoma
Authors: Lee Mi‐Woo , Chi Doo‐Hyun , Choi Jee‐Ho , Sung Kyung‐Jeh , Moon Kee‐Chan , Koh Jai‐Kyoung 
Published: April 2015

AbstractA 55‐year‐old woman presented with mycosis fungoides (MF) after the total excision of primary cutaneous CD30+ anaplastic large cell lymphoma (ALCL). In the specimens obtained from the nodule of CD30+ ALCL and the plaque lesion of MF, the same pattern of T‐cell receptor gene rearragement was detected.
Phakomatosis Pigmentovascularis with Sturge‐Weber Syndrome: A Case Report
Authors: Uysal Gülnar , Güven Alev , Özhan Bayram , Öztürk M. Halil , Mutluay A. Hürriyet , Tulunay Özden 
Published: April 2015

AbstractWe describe here a Turkish girl with pigmentovascularis type 2b, consisting of disseminated Mongolian‐spot‐like maculae and unilateral Sturge‐Weber angiomatosis.
Myxomatous Granulation as a Feature of a Subcutaneous Pseudotumor
Authors: Horiuchi Yasuhiro 
Published: April 2015

AbstractThis paper presents myxomatous granulation in the sacral area as a feature of a pseudotumor. The patient was an 86‐year‐old male with a pseudotumor in the sacral area that may possibly have been the result of prolonged bed confinement. The initial diagnosis was lipoma. Specimen examination disclosed granulation tissue with inflammatory mixed cellular infiltrates undergoing myxomatous change. Plasma cell infiltrates were frequently present.
Soluble Thrombomodulin, a Possible Predictor of Thrombotic Crisis in Thrombotic Disease
Authors: Fujita Hiroshi 
Published: April 2015

AbstractSerum soluble thrombomodulin is known to be a factor in visceral vascular disorders such as organic vasculitis in collagen diseases, but recently it has also been reported as a predictor of thrombotic crisis in thrombotic diseases. In this report, serum soluble thrombomodulin levels and events of thrombotic crises in clinical patients were studied retrospectively in our dermatology department over the past five years. I found an increase in soluble thrombomodulin one to two months before the crisis in eight of ten patients including three with anti‐phospholipid syndrome, two with lupus anticoagulant‐positive systemic lupus erythematosus, four patients with chronic disseminated intravascular coagulation syndrome and one patient with thrombotic thrombocytepenic purpura. A decrease was found after treatment. Other tested parameters did not respond as soluble thrombomodulin, and they were not useful for predicting the crisis one to two months before the crisis. These results suggest the possibility that soluble thrombomodulin might be an important factor in predicting thrombotic crisis.
Lichen Planus after HBV Vaccination in a Child: A Case Report from Nepal
Authors: Agrawal Sudha , Garg Vijay Kumar , Joshi Arun , Agarwalla Arun , Sah Shatrughan Prasad 
Published: April 2015

AbstractVaccination against hepatitis B virus has rarely been associated with lichen planus. We report a case of this kind in a child from Nepal. A 12‐year‐old boy had developed generalized itchy violaceous papules and plaques six weeks after the second dose of hepatitis B virus vaccine. Serum HBsAg and HBeAb were negative, but HBsAb was positive. New crops of generalized, similar eruptions developed after the booster dose of vaccine. All the lesions resolved within three months of systemic steroid therapy. There was no recurrence after one year of follow up. Awareness of such an association is necessary, especially in children, because vaccination campaigns are increasing.