bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Synthesis, and Preliminary Antiproliferative Evaluation of 1,2,4-Thiadiazole Derivatives as Possible Histone Deacetylase Inhibitors
Authors: Rusul Mohammed Hasan Ali  , Al-Hamashi Ayad 
Published: February 2025

Histone deacetylases (HDACs) are a class of proteins that responsible of the hydrolysis of N-acetyl lysine residues in histones as well as non-histone protein substrates. This phenomenon may provide an explanation for the involvement of these enzymes in a wide range of clinical situations, encompassing cancer, metabolic, cardiovascular problems, and neurological diseases. Most of HDAC inhibitors are often used in clinical settings consist of a hydroxamate group (ZBG) that binds to zinc ion inside the active site. The poor selectivity and pharmacokinetic characteristics of numerous medicines belonging to the hydroxamates group have prompted the exploration of non-hydroximic ZBG HDAC inhibitors with a potential selectivity and potency profile. Therefore, the objective of this work is to design new HDAC inhibitors incorporating thiadiazole moiety as a ZBG. This study involved the design and virtual analysis of a series of thiadiazole derivatives using Maestro software. Compounds with good docking score which include compound 6a [4- (benzyloxy)-N-(1,2,4-thiadiazol-5-yl)benzamide] with docking score -8.953 kcal/mol and compound 6b [4-(naphthalen-1-ylmethoxy)-N-(1,2,4-thiadiazol-5- yl)benzamide] with docking score -9.290 kcal/mol and compound 6c[ 4-((4-methoxybenzyl)oxy)benzoic acid] with docking score -8.57 kcal/mol while the FDA approved vorinostat has a docking score -5.613 kcal/mol against HDAC 2 (4LXZ). Compound 6a, 6b and 6c were subjected to the organic synthesis applying traditional chemical reactions. The synthesis was commenced with the ether formation using Williamson reaction by reacting benzylic bromide derivatives with methyl 4-hydroxybenzoate, then the intermediates underwent ester hydrolysis to produce 4-(benzyloxy)benzoic acid derivatives and then reacted with 1,2,4-thiadiazol-5- amine by forming amide using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as coupling reagent. The intermediates and final products were characterized by FT-IR and NMR spectroscopy. The cytotoxic effect was assessed using the MTT cell viability assay indicate that IC50 of 6b is 0.66 μM while the IC50 of vorinostat is 1.48 μM.
PELATIHAN DEEP BREATHING DAN MANAGEMEN STRESS DALAM PENERIMAAN DIRI ANAK PENYANDANG DISABILITAS DI YAYASAN RUMAH DISABILITAS BORNEO BANJARMASIN
Authors: Abidarda Yulizar , Habibie Muhammad , Mahfuz Mahfuz 
Published: February 2025

Stigma masyarakat terhadap anak disabilitas terkadang masih kuat pada kumpulan masyarakat ini, karena rendahnya pengetahuan dan faktor sosial budaya. Anak penyandang disabilitas memiliki banyak hambatan pada beberapa aspek perkembangan sehingga memerlukan terapi, sarana dan prasarana serta bentuk dukungan dalam penerimaan dirinya. manajemen stress merujuk pada identifikasi dan analisis terhadap permasalahan yang terkait dengan stres dan aplikasi berbagai alat teraupetik untuk mengubah sumber stres atau pengalaman stres. Teknik Relaksasi Nafas Dalam (Deep Breathing) adalah suatu teknik olah nafas yang bertujuan untuk meningkatkan ventilasi alveoli dan mengurangi stres baik stres fisik maupun emosional yaitu menurunkan intensitas nyeri dan menurunkan kecemasan. Solusi dalam pengabdian ini: 1) Upaya membantu anak disabilitas dalam mengatasi penerimaan diri, 2) Memberikan pelatihan deep breathing dan managemen stress bagi anak disabilitas dalam penerimaan diri untuk mengatasi permasalahan yang terjadi pada mereka Di Yayasan Rumah Disabilitas Borneo Banjarmasin. Kegiatan pelatihan ini dilaksanakan selama 1 kali pertemuan atau setara dengan 2,5 jam pelatihan dengan berbagai metode seperti ceramah, demonstrasi, dan praktek tersupervisi. Khalayak sasaran pada kegiatan ini adalah 11 anak penyandang disabilitas pada yayasan rumah disabilitas borneo Banjarmasin. Hasil evaluasi menunjukkan terjadi peningkatan penerimaan diri anak penyandang disabilitas tunarungu setelah diberikan pelatihan deep breathing dan managemen stress.
MANAJEMEN PERENCANAAN KARIER BAGI PENYANDANG DISABILITAS DI RUMAH DISABILITAS BORNEO BANJARMASIN
Authors: Prasetia Muhammad Eka , Heiriyah Ainun , Pratiwi Endang 
Published: February 2025

Sumber daya manusia merupakan hal yang penting karena individu (manusia) inilah yang akan menggerakkan seluruh komponen yang berbeda dalam kehidupan. Setiap individu dapat mengembangkan dan merealisasikan kompetensinya secara penuh dan memiliki hak untuk mengembangkan potensi perencanaan kariernya. Anak berkebutuhan khusus (ABK) atau penyandang disabilitas, seperti halnya anak normal lainnya, juga mempunyai kesempatan yang baik dalam melakukan pendidikan ataupun dalam hal memasuki dunia kerja. Keterbatasan fisik yang dialami penyandang disabilitas tidak selamanya bergantung kepada orang lain, mereka juga dapat hidup seperti orang normal pada umumnya baik dalam memenuhi kebutuhan sehari-hari, bekerja serta menghasilkan karya kecuali penyandang disabilitas berat. Dengan itu sebelum melaksanakan karir yang sebenarnya maka diperlukan perencanaan karir terlebih dahulu guna mempersiapkan karir saat usia kerja. Salah satu perencanaan karir yang diberikan kepada anak berkebutuhan khusus atau penyandang distabilitas salah satunya adalah keterampilan (kecakapan) untuk upaya mewujudkan nilai tambah bagi anak berkebutuhan khusus atau penyandang distabilitas dalam mempersiapkan diri memasuki dunia kerja. Dengan memberikan support dan arahan dari beberapa pihak (keluarga, kerabat, organisasi, lembaga, masyarakat, dll) kepada anak berkebuthan khusus (ABK) atau penyandang disabilitas sehingga mereka memiliki kemampuan keterampilan (skill) agar dapat bersaing sehat di dunia pendidikan ataupun dunia kerja.Terdapat tiga metode dalam pelaksanaan kegiatan pengabdian kepada masyarakat yang digunakan diantaranya: (1) ceramah; (2) pelatihan; dan (3) evaluasi. Peserta kegiatan terdiri dari 10 orang remaja disabilitas yang hadir pada saat kegiatan pengabdian kepada masyarakat.Hasil kegiatan Workshop Manajemen Perencanaan Karier Remaja disabilitas di rumah disabilitas borneo Banjarmasin menghasilkan: (1) Remaja disabilitas di rumah disabilitas borneo Banjarmasin dapat melakukan manajemen perencanaan karier; (2) Hasil Pretes pengetahuan manajemen perencanaan karier remaja penyandang disabilitas pada rumah disabilitas borneo banjarmasin adalah tergolong kategori Rendah (1,63); dan (3) Hasil Posttes pengetahuan manajemen perencanaan karier remaja penyandang disabilitas pada rumah borneo banjarmasin adalah tergolong kategori Sedang (4,4) Kata kunci: Manajemen, perencanaan karier
Pemberdayaan Masyarakat Dusun Cendrawasih Melalui Pendampingan Produksi Pupuk Kompos Eceng Gondok
Authors: Suryani Rini , Rizieq Rahmatullah , Reswari Rianti Ardana , Ekawati Ekawati 
Published: February 2025

Tertutupnya permukaan sungai oleh eceng gondok berdampak negatif terhadap lingkungan terutama menyebabkan pendangkalan Sungai. Hal ini terjadi khususnya di RT. 005 Dusun Cendrawasih Kabupaten Kubu Raya. Eceng gondok tersebut belum dimanfaatkan secara ekonomis, saat ini Eceng gondok hanya dikendalikan dengan menggunakan herbisida. Pertumbuhan eceng berlangsung sangat cepat sehingga menjadi permasalahan bagi warga RT. 005 Dusun Cendrawasih Kabupaten Kubu Raya. Eceng gondok dapat diolah menjadi produk bernilai ekonomis salah satunya pupuk kompos. Pupuk kompos Eceng gondok dapat dimanfaatkan bagi warga RT 005 Dusun Cendrawasih yang Sebagian besar berprofesi sebagai petani. Kegiatan PKM ini dilakukan bertujuan untuk menghasilkan produk olahan Eceng gondok berupa pupuk kompos. Adapun teknologi yang disiapkan guna mendukung pproduksi kompos yaitu mesin pencacah Eceng gondok. Mesin ini dapat memudahkan proses pencacahan ukuran eceng gondok yang akan dikomposkan. Dimana semakin kecil ukuran bahan baku kompos maka akan menghemat waktu dan memprcepat pengomposan. Selain itu, melalui PKM ini bertujuan pula untuk meningkatkan mutu produk termasuk pengemasan atau packaging sehingga menjadi produk yang siap untuk dipasarkan. Setelah dilakukannya PKM, Kelompok Tani Usaha Bersama Kecamatan Sungai Kakap Kabupaten Kubu Raya terjadi peningkatan pengetahuan, sikap dan keterampilan dalam membuat kompos dan melakukan pengemasan pupuk kompos Eceng gondok. Produk pupuk kompos Eceng gondok dapat menjadi sebagai usaha baru bagi warga RT. 005 Dusun Cendrawasih. Pupuk kompos Eceng gondok ini dapat menjadi alternatif pengganti pupuk kimia dalam upaya peningkatan produksi tanaman budidaya sayuran di daerah tersebut.
PELATIHAN PENGOLAHAN SILASE JERAMI JAGUNG SEBAGAI SUMBER PAKAN SAPI POTONG DI KECAMATAN PATAMPANUA KABUPATEN PINRANG
Authors: Syamsu Jasmal Ahmari , Purwanti Sri , Adzima Ahmad Fauzan , Munir Munir , Fuad AW Andi Muhammad , Amal Ichlasul 
Published: February 2025

Pelatihan teknologi pengolahan silase jerami jagung dilaksanakan sebagai bagian kegiatan pengabdian kepada masyarakat Program Pemberdayaan Wilayah Kecamatan Patampanua Kabupaten Pinrang. Pelatihan pengolahan silase jerami jagung sebagai pakan sapi potong bertujuan untuk meningkatkan keterampilan dan penguasaan teknologi petani peternak dalam hal pakan ternak. Tahapan kegiatan pelatihan pengolahan silase jerami jagung meliputi tahapan persiapan dan pelaksanaan, dan pendampingan kegiatan. Dalam pelaksanaan pelatihan, respon peternak sangat tinggi. Peternak memahami dengan baik pengolahan silase jerami jagung sehingga terjadi peningkatan pengetahuan peternak dalam usaha penyediaan pakan untuk sapi potong. Pelatihan silase jerami jagung berhasil meningkatkan pengetahuan peserta secara signifikan di semua aspek, terutama pada bahan fermentasi dan alat pengolahan, berkat pendekatan yang terstruktur.
Quantity versus quality: analysis of research publications in the 2023 neurosurgery match
Authors: Wang Alexander F. , Wetzel Ethan A. , West Timothy R. , Muzyka Logan , Runde Andreas C. , Nasser Ali M. , Batsaikhan Uyanga , Shankar Ganesh M. , Choi Bryan D. , Nahed Brian V. 
Published: February 2025

OBJECTIVE
Prematch research productivity is a heavily utilized metric in evaluating neurosurgery residency applicants. With the rise in research output by successfully matched candidates and the so-called publication arms race, there is a growing interest in understanding the quality and impact of the research conducted by medical students who secure neurosurgery residency positions. This study aimed to characterize the research output of medical students who matched into neurosurgery in 2023, identify predictors of research productivity, and explore the implications of research output on match outcomes.

METHODS
First-year neurosurgery residents from the 2023 match were identified via program websites. Research output data were collected from the PubMed and Scopus databases, excluding publications released after the 2023 National Resident Matching Program deadline. Predictive analyses were conducted using multiple linear regression models.

RESULTS
Data were obtained for 242 1st-year neurosurgery residents and 2519 PubMed-indexed publications. The median numbers of total and first author publications were 7 (range 0–73) and 2 (range 0–25), respectively. The median number of citations was 28 (range 0–1010), with a median impact factor of 3.1 (range 0–30.43). Most publications represented retrospective clinical research (n = 839). Of the neurosurgery-related publications, spine-related research was most common (n = 410), while peripheral nerve research was the least common (n = 20). Factors associated with higher publication output included attending a top 20–ranked U.S. News & World Report medical school (p = 0.00044), international medical graduate status (p = 1.95e−6), and obtaining a doctor of philosophy degree (p = 0.00582). Applicants who published more than 30 papers averaged 4.16 citations per paper, whereas residents who published fewer than 30 papers averaged 8.34 citations per paper (p = 0.0006).

CONCLUSIONS
This study characterizes the research output of successfully matched neurosurgery applicants and identifies medical school ranking and degree status as predictors of research productivity. Interestingly, only the rank of the medical school attended predicted better match outcomes despite an overall shift to utilizing research as a metric of merit in residency applications in reaction to an increase in pass/fail medical school curriculums and changes in United States Medical Licensing Examination Step 1 grading systems. These findings also demonstrate that residents who published the most papers published the lowest-impact research, which aligns with the notion that there is an increased emphasis on publication quantity rather than publication quality.
Microsurgical clipping for intracranial aneurysms in elderly patients: outcomes comparable to those in younger cohorts
Authors: Roy Joanna M. , Musmar Basel , Lan Matthews , Majmundar Shyam , Amaravadi Cheritesh , Winiker Sarah , Morse Charles , Sais Erica , Patel Shray , El Naamani Kareem , Tjoumakaris Stavropoula I. , Gooch M. Reid , Rosenwasser Robert H. , Jabbour Pascal M. 
Published: February 2025

OBJECTIVE
In recent years, there has been a shift toward the endovascular treatment of intracranial aneurysms, particularly among elderly patients, that is, those aged 70 years and older. However, microsurgical clipping remains the preferred modality for aneurysms of a certain morphology and location. The authors of this study aimed to compare the outcomes of clipping on the basis of age.

METHODS
This was a retrospective single-center study of patients who had undergone microsurgical clipping of an intracranial aneurysm between February 2016 and November 2022. Propensity scores were estimated using the 1:2 nearest neighbor method. Outcomes of interest were intraoperative and postoperative complications, length of stay (LOS), nonhome discharge (NHD), functional dependence on discharge, and mortality.

RESULTS
After propensity score matching, 50 patients older than 70 years were matched with 100 patients younger than 70 years of age. Aneurysm location, morphology, and rupture status were comparable between the matched cohorts. There was no significant difference in complications (14.0% for age ≥ 70 vs 13.0% for age < 70, p > 0.99), extended LOS (30% vs 19%, respectively, p = 0.129), NHD (38.0% vs 26.0%, respectively, p = 0.131), functional dependence on discharge (22% vs 17%, respectively, p = 0.509), or mortality (8.0% vs 2.0%, respectively, p = 0.077).

CONCLUSIONS
The study results demonstrated rates of complications, LOS, NHD, functional dependence, and mortality in elderly patients comparable to those in younger patients. The authors acknowledge the importance of patient selection and encourage further studies to assess the safety of clipping in the elderly.
Presenting cerebrovascular reactivity as a determinant of direct and indirect surgical revascularization success in North American patients with moyamoya vasculopathy
Authors: Shiino Shuhei , Han Caleb , Garza Maria , Fusco Matthew , Chitale Rohan , Davis L. Taylor , Richerson Wesley , Rodeghier Mark , Dubois Abigail R. , Leguizamon Melanie , Hett Kilian , Jordan Lori C. , Donahue Manus J. 
Published: February 2025

OBJECTIVE
Both direct and indirect surgical revascularization techniques are commonly applied for the treatment of moyamoya disease and syndrome; however, responses can be heterogeneous and efficacy in the context of ischemic disease is not yet formally known from randomized clinical trials. Here, a prospective, longitudinal interventional study was performed to test the hypothesis that presenting 1) parenchymal cerebrovascular reactivity (CVR) and 2) CVR response times portend hemodynamic improvements after direct and indirect revascularization.

METHODS
Catheter angiography and hypercapnic blood oxygenation–weighted 3-T MRI (spatial resolution 3.5 × 3.5 × 3.5 mm, repetition time 2000 msec) were acquired before and 11.0 ± 7.9 months and 12.6 ± 6.9 months after surgery, respectively. In response to a 5% fixed-inspired CO2 respiratory challenge, time regression analyses were utilized to quantify maximal cerebrovascular reactivity (CVRmax) and time to reach maximal cerebrovascular reactivity (CVRdelay) to test the overarching hypothesis that presurgical measures predicted postsurgical CVRmax increases and CVRdelay reductions. Age, sex, surgical type, and preoperative impairment were considered as relevant explanatory variables in the regression analysis (significance criterion p < 0.05).

RESULTS
A total of 47 operative hemispheres (32 indirect-only and 15 direct or combined direct-indirect revascularization) from 30 adult patients (median [range] age 43 [20–59] years) were evaluated. Direct/combined versus indirect revascularized brain hemispheres were matched for age (44.1 ± 11.1 vs 44.7 ± 13.8 years, p = 0.864), prior infarct (92.9% vs 92.6%, p = 0.976), and Suzuki stage within 1 stage on the 6-point staging scale (4.1 ± 0.7 vs 3.4 ± 0.6). Across all hemispheres and surgical procedures, CVRmax increased (p = 0.022) and CVRdelay decreased (p = 0.009) after surgery; however, responses varied considerably across hemispheres and surgical procedures. On multiple regression analysis, extent of preoperative impairment, quantified as preoperative CVRmax and moderated by the type of surgery performed, was an indicator of intervention-induced outcome in hemodynamics (p = 0.015). No effect of preoperative CVRdelay or age was found for outcomes.

CONCLUSIONS
The findings confirm heterogeneous CVR responses approximately 1 year after revascularization across patients, albeit moderated by type of revascularization. Of the variables considered, lower presurgical CVR provided the most significant indicator of the likelihood of postsurgical hemodynamic improvement.
Connectomic-guided stereotactic radiosurgery thalamotomy for tremor: a patient-specific approach to enhance outcomes
Authors: Middlebrooks Erik H. , Patel Vishal , Popple Richard A. , Walker Harrison C. , Thomas Evan M. , Brinkerhoff Sarah A. , Anderson Ashley R. , Deshpande Hrishikesh D. , McCullough Benjamin A. , Stover Natividad P. , Sung Victor W. , Nicholas Anthony P. , Standaert David G. , Yacoubian Talene , Dean Marissa N. , Roper Jaimie A. , Grewal Sanjeet S. , Holland Marshall T. , Bentley J. Nicole , Guthrie Barton L. , Bredel Markus 
Published: February 2025

OBJECTIVE
Stereotactic radiosurgery (SRS) is an effective treatment for refractory tremor. However, the lack of reliable patient-specific targeting biomarkers leads to varying outcomes. Although connectomic-based targeting is commonly used in deep brain stimulation, its application in SRS is limited. This study aimed to develop a new targeting approach by using patient-specific structural connectivity to improve outcomes after SRS.

METHODS
The authors performed a retrospective study of patients in a prospective trial for frameless virtual-cone SRS on a linear accelerator for essential tremor or tremor-dominant Parkinson disease. The primary endpoint was percentage improvement in Fahn-Tolosa-Marin tremor rating scale scores contralateral to the treatment side. Probabilistic tractography assessed connectivity from each thalamic voxel to the primary motor cortex (M1), primary sensory cortex (S1), and supplemental motor area/premotor cortex (SMA/PMC). Group-level comparisons were conducted to evaluate the relationship between the sweet spot for maximum contralateral tremor improvement and areas maximally connected to M1, S1, and SMA/PMC. Multiple regression analysis assessed the relationship between the lesion centerpoint coordinates and the maximally connected voxel to M1, S1, and SMA/PMC at the individual level.

RESULTS
The analysis included 27 patients with a mean follow-up of 17.9 ± 11.1 months. The sweet spot for maximal contralateral tremor improvement at the group level was in the region most connected to M1 cortex. Smaller y-distances (anterior-posterior) from the lesion center to the M1 maximally connected voxel significantly correlated with tremor improvement at the single-subject level (p < 0.001). However, the authors found no significant correlation between the lesion y-coordinate and the maximally connected voxel to SMA/PMC and S1, nor between the x-distances from the lesions to the SMA/PMC, M1, and S1 voxels (p > 0.07).

CONCLUSIONS
This study demonstrates that patient-specific connectivity between the treatment target and M1 correlates with treatment outcomes. The authors’ approach provides a practical targeting method for SRS thalamotomy for tremor.
Morphology and outcomes in combined sagittal and unilateral coronal synostosis
Authors: Tandon Damini , Burton Jackson S. , Karsten Madeline , Skolnick Gary B. , Naidoo Sybill D. , Proctor Mark R. , Smyth Matthew D. , Patel Kamlesh B. 
Published: February 2025

OBJECTIVE
Combined sagittal and unilateral coronal synostosis is an uncommon multisuture synostosis. The objective of this study was to describe patient demographics, characterize craniofacial morphology, and report surgical outcomes for patients with combined sagittal and unilateral coronal synostosis undergoing surgical repair.

METHODS
This was a retrospective cohort study performed as a joint effort between two US pediatric tertiary care institutions. Between 2003 and 2021, 10 patients with combined sagittal and unilateral coronal synostosis who underwent surgical repair were identified. Open repair involved fronto-orbital advancement and calvarial remodeling. Endoscopic repair involved endoscopy-assisted strip craniectomy of fused sutures with subsequent helmet therapy until 12 months of age. Craniofacial morphology was characterized from CT scans with parameters including the cephalic index (CI), orbital index (OI) asymmetry, nasal tip deviation, chin deviation, and anterior cranial fossa area ratio (ACFR). All patients had preoperative CT scans, and postoperative CT scans were analyzed when performed. Demographics, operative details, and complications were obtained via chart review.

RESULTS
Patients were predominantly male (70%) with fusion of left coronal suture (80%). Four patients (40%) underwent open repair, and 6 patients (60%) underwent endoscopic repair. The median operation length was 87 minutes for endoscopic repair and 226 minutes for open repair. Two endoscopic patients (33%) and 2 open patients (50%) required blood transfusion. Four patients (3 endoscopic, 1 open) underwent secondary operations.
Preoperatively (n = 10), patients had a median CI of 0.75, with OI asymmetry (median −35%), nasal tip (median 6.9°) and chin deviation (median 9.5°) contralateral to the involved coronal suture, and cranial base asymmetry (median ACFR 0.63). Postoperatively (n = 6), patients had improved CI (median CI 0.81), OI asymmetry (median −22%), chin deviation (median 5.1°), and cranial base asymmetry (median ACFR 0.75) but slightly worse nasal tip deviation (median 8.5°).

CONCLUSIONS
Combined sagittal and unilateral coronal synostosis resembles its isolated component phenotypes. Open and endoscopic repairs are safe. Morphological parameters trended toward improvement postoperatively.