bluuebunny/crossref_metadata_2025_split huggingface dataset:
European Integration and Spatial Wage Structure in Poland
Authors: Cieślik Andrzej , Rokicki Bartłomiej 
Published: November 2015

ABSTRACTIn this paper we examine the relationship between average wages and market potential across Polish 16 NUTS 2 administrative units during the 1995–2009 period to study the effects of increased international market access using the new economic geography approach. In particular, we estimate the relationship between average regional wages and the market‐potential function derived from the modified Helpman‐Hanson theoretical model. We demonstrate that both before and after Poland's entry into the European Union the regional economic potential is positively related to the regional level of wages. The magnitude of the estimated parameters on the market potential after Poland's entry into the EU is lower compared to the estimates obtained for the period before the entry but the difference does not seem significant.
Risk Factors for Dehiscence of Stapled Functional End‐to‐End Intestinal Anastomoses in Dogs: 53 Cases (2001–2012)
Authors: Snowdon Kyle A. , Smeak Daniel D. , Chiang Sharon 
Published: November 2015

ObjectiveTo identify risk factors for dehiscence in stapled functional end‐to‐end anastomoses (SFEEA) in dogs.Study DesignRetrospective case series.AnimalsDogs (n = 53) requiring an enterectomy.MethodsMedical records from a single institution for all dogs undergoing an enterectomy (2001–2012) were reviewed. Surgeries were included when gastrointestinal (GIA) and thoracoabdominal (TA) stapling equipment was used to create a functional end‐to‐end anastomosis between segments of small intestine or small and large intestine in dogs. Information regarding preoperative, surgical, and postoperative factors was recorded.ResultsAnastomotic dehiscence was noted in 6 of 53 cases (11%), with a mortality rate of 83%. The only preoperative factor significantly associated with dehiscence was the presence of inflammatory bowel disease (IBD). Surgical factors significantly associated with dehiscence included the presence, duration, and number of intraoperative hypotensive periods, and location of anastomosis, with greater odds of dehiscence in anastomoses involving the large intestine.ConclusionIBD, location of anastomosis, and intraoperative hypotension are risk factors for intestinal anastomotic dehiscence after SFEEA in dogs. Previously suggested risk factors (low serum albumin concentration, preoperative septic peritonitis, and intestinal foreign body) were not confirmed in this study.
Effects of unsaturated fatty acids on the kinetics of voltage‐gated proton channels heterologously expressed in cultured cells
Authors: Kawanabe Akira , Okamura Yasushi 
Published: November 2015

Key points
Arachidonic acid (AA) greatly enhances the activity of the voltage‐gated proton (Hv) channel, although its mechanism of action and physiological function remain unclear.
In the present study, we analysed the effects of AA on proton currents through Hv channels heterologously expressed in HEK293T cells.
The dramatic increase in proton current amplitude elicited by AA was accompanied by accelerated activation kinetics and a leftward shift in the voltage‐dependence of activation.
Mutagenesis studies suggest the two aforementioned effects of AA reflect two distinct structural mechanisms.
Application of phospholipase A2, which liberates AA from phospholipids in the membrane, also enhances Hv channel activity, supporting the idea that AA modulates Hv channel activity within physiological contexts.
AbstractUnsaturated fatty acids are key components of the biological membranes of all cells, and precursors of mediators for cell signalling. Arachidonic acid (AA) is an unsaturated fatty acid known to modulate the activities of various ion channels, including the voltage‐gated proton (Hv) channel, which supports the rapid production of reactive oxygen species (ROS) in phagocytes through regulation of pH and membrane potential. However, the molecular mechanisms and physiological functions of the effects of AA on Hv channels remain unclear. In the present study, we report an electrophysiological analysis of the effects of AA on the mouse Hv channel (mHv1) heterologously expressed in HEK293T cells. Application of AA to excised inside‐out patch membranes rapidly induced a robust increase in the amplitude of the proton current through mHv1. The current increase was accompanied by accelerated activation kinetics and a small leftward shift of the current–voltage relationship. In monomeric channels lacking the coiled‐coil region of the channel protein, the shift in the current–voltage relationship was diminished but activation and deactivation remained accelerated. Studies with several AA derivatives showed that double bonds and hydrophilic head groups are essential for the effect of AA, although charge was not important. The application of phospholipase A2 (PLA2), which generates AA from cell membrane phospholipids, stimulated mHv1 activity to a similar extent as direct application of ∼20 μm AA, suggesting that endogenous AA may regulate Hv channel activity.
A patient‐specific aperture system with an energy absorber for spot scanning proton beams: Verification for clinical application
Authors: Yasui Keisuke , Toshito Toshiyuki , Omachi Chihiro , Kibe Yoshiaki , Hayashi Kensuke , Shibata Hiroki , Tanaka Kenichiro , Nikawa Eiki , Asai Kumiko , Shimomura Akira , Kinou Hideto , Isoyama Shigeru , Fujii Yusuke , Takayanagi Taisuke , Hirayama Shusuke , Nagamine Yoshihiko , Shibamoto Yuta , Komori Masataka , Mizoe Jun‐etsu 
Published: November 2015

Purpose:In the authors’ proton therapy system, the patient‐specific aperture can be attached to the nozzle of spot scanning beams to shape an irradiation field and reduce lateral fall‐off. The authors herein verified this system for clinical application.Methods:The authors prepared four types of patient‐specific aperture systems equipped with an energy absorber to irradiate shallow regions less than 4 g/cm2. The aperture was made of 3‐cm‐thick brass and the maximum water equivalent penetration to be used with this system was estimated to be 15 g/cm2. The authors measured in‐air lateral profiles at the isocenter plane and integral depth doses with the energy absorber. All input data were obtained by the Monte Carlo calculation, and its parameters were tuned to reproduce measurements. The fluence of single spots in water was modeled as a triple Gaussian function and the dose distribution was calculated using a fluence dose model. The authors compared in‐air and in‐water lateral profiles and depth doses between calculations and measurements for various apertures of square, half, and U‐shaped fields. The absolute doses and dose distributions with the aperture were then validated by patient‐specific quality assurance. Measured data were obtained by various chambers and a 2D ion chamber detector array.Results:The patient‐specific aperture reduced the penumbra from 30% to 70%, for example, from 34.0 to 23.6 mm and 18.8 to 5.6 mm. The calculated field width for square‐shaped apertures agreed with measurements within 1 mm. Regarding patient‐specific aperture plans, calculated and measured doses agreed within −0.06% ± 0.63% (mean ± SD) and 97.1% points passed the 2%‐dose/2 mm‐distance criteria of the γ‐index on average.Conclusions:The patient‐specific aperture system improved dose distributions, particularly in shallow‐region plans.
Depth‐resolved registration of transesophageal echo to x‐ray fluoroscopy using an inverse geometry fluoroscopy system
Authors: Hatt Charles R. , Tomkowiak Michael T. , Dunkerley David A. P. , Slagowski Jordan M. , Funk Tobias , Raval Amish N. , Speidel Michael A. 
Published: November 2015

Purpose:Image registration between standard x‐ray fluoroscopy and transesophageal echocardiography (TEE) has recently been proposed. Scanning‐beam digital x‐ray (SBDX) is an inverse geometry fluoroscopy system designed for cardiac procedures. This study presents a method for 3D registration of SBDX and TEE images based on the tomosynthesis and 3D tracking capabilities of SBDX.Methods:The registration algorithm utilizes the stack of tomosynthetic planes produced by the SBDX system to estimate the physical 3D coordinates of salient key‐points on the TEE probe. The key‐points are used to arrive at an initial estimate of the probe pose, which is then refined using a 2D/3D registration method adapted for inverse geometry fluoroscopy. A phantom study was conducted to evaluate probe pose estimation accuracy relative to the ground truth, as defined by a set of coregistered fiducial markers. This experiment was conducted with varying probe poses and levels of signal difference‐to‐noise ratio (SDNR). Additional phantom and in vivo studies were performed to evaluate the correspondence of catheter tip positions in TEE and x‐ray images following registration of the two modalities.Results:Target registration error (TRE) was used to characterize both pose estimation and registration accuracy. In the study of pose estimation accuracy, successful pose estimates (3D TRE < 5.0 mm) were obtained in 97% of cases when the SDNR was 5.9 or higher in seven out of eight poses. Under these conditions, 3D TRE was 2.32 ± 1.88 mm, and 2D (projection) TRE was 1.61 ± 1.36 mm. Probe localization error along the source‐detector axis was 0.87 ± 1.31 mm. For the in vivo experiments, mean 3D TRE ranged from 2.6 to 4.6 mm and mean 2D TRE ranged from 1.1 to 1.6 mm. Anatomy extracted from the echo images appeared well aligned when projected onto the SBDX images.Conclusions:Full 6 DOF image registration between SBDX and TEE is feasible and accurate to within 5 mm. Future studies will focus on real‐time implementation and application‐specific analysis.
Genome Sequence of Salmonella enterica subsp.
enterica
Serovar Typhi Isolate PM016/13 from Untreated Well Water Associated with a Typhoid Outbreak in Pasir Mas, Kelantan, Malaysia
Authors: Muhamad Harish Salwani , Sim Kee-Shin , Najimudin Nazalan , Aziah Ismail 
Published: November 2015

ABSTRACT

Salmonella enterica
subsp.
enterica
serovar Typhi is a human-restricted pathogen that causes typhoid fever. Even though it is a human-restricted pathogen, the bacterium is also isolated from environments such as groundwater and pond water. Here, we describe the genome sequence of the
Salmonella enterica
subsp.
enterica
serovar Typhi PM016/13 which was isolated from well water during a typhoid outbreak in Kelantan, Malaysia, in 2013.
Full-Length Genome Sequences of Senecavirus A from Recent Idiopathic Vesicular Disease Outbreaks in U.S. Swine
Authors: Zhang Jianqiang , Piñeyro Pablo , Chen Qi , Zheng Ying , Li Ganwu , Rademacher Christopher , Derscheid Rachel , Guo Baoqing , Yoon Kyoung-Jin , Madson Darin , Gauger Phillip , Schwartz Kent , Harmon Karen , Linhares Daniel , Main Rodger 
Published: November 2015

ABSTRACT
Since July 2015, vesicular lesions affecting growing pigs and sows accompanied with neonatal mortality have been reported in multiple U.S. states. Senecavirus A has been consistently detected from these cases. The complete genome sequences of 3 recent U.S. Senecavirus A isolates were determined to further characterize this virus.
Genome Sequence of Bacillus anthracis Larissa, Associated with a Case of Cutaneous Anthrax in Greece
Authors: Grass Gregor , Hanczaruk Matthias , Antwerpen Markus 
Published: November 2015

ABSTRACT

We report the genome sequence of
Bacillus anthracis
strain Larissa, isolated from a diseased sheep associated with a human case of cutaneous anthrax in Central Greece from 2012. Genome sequence analysis of strain Larissa may aid in describing phylogenetic relationships of
B. anthracis
isolates in Southeastern European countries.
A Novel Member of
Chitinophagaceae
Isolated from a Human Peritoneal Tumor
Authors: Lo Alexander S. , Merrell D. Scott , Lei Haiyan , Sardi Armando , McAvoy Thomas , Testerman Traci L. 
Published: November 2015

ABSTRACT

Peritoneal tumors from a rare malignancy, pseudomyxoma peritonei, frequently contain bacteria. Evidence suggests that tumor-associated bacteria contribute to pseudomyxoma peritonei development and/or progression. One unique isolate (PMP191F) was characterized via whole-genome sequencing using the Illumina MiSeq platform. PMP191F shows similarities to the
Chitinophaga, Niastella
, and
Flavitalea
genera.
Draft Genome Sequence of Bacillus amyloliquefaciens XK-4-1, a Plant Growth-Promoting Endophyte with Antifungal Activity
Authors: Sun Zhengxiang , Hsiang Tom , Zhou Yi , Zhou Jinglong 
Published: November 2015

ABSTRACT

Here, we report the draft genome sequence of a bacterial plant-growth-promoting endophyte,
Bacillus amyloliquefaciens
XK-4-1, which consists of one circular chromosome of 3,941,805 bp with 3,702 coding sequences (CDSs). The data presented highlight multiple sets of functional genes associated with its plant-beneficial characteristics.
Genome Sequence of a Clinical Klebsiella pneumoniae Sequence Type 6 Strain
Authors: Guilhen Cyril , Iltis Agnès , Forestier Christiane , Balestrino Damien 
Published: November 2015

ABSTRACT

We report here the genome sequence of
Klebsiella pneumoniae
CH1034, a sequence type 6 (ST6) strain isolated in 2012 from a central venous catheter of a hospitalized patient.
Draft Genome Sequence of Burkholderia cenocepacia Strain 869T2, a Plant-Beneficial Endophytic Bacterium
Authors: Ho Ying-Ning , Huang Chieh-Chen 
Published: November 2015

ABSTRACT

An endophytic bacterium,
Burkholderia cenocepacia
869T2, isolated from vetiver grass, has shown its abilities for both
in planta
biocontrol and plant growth promotion. Its draft genome sequence was determined to provide insights into those metabolic pathways involved in plant-beneficial activity. This is the first genome report for endophytic
B. cenocepacia
.
Draft Genome Sequence of a Benzo[
a
]pyrene-Degrading Bacterium,
Olleya
sp. Strain ITB9
Authors: Okai Masahiko , Watanabe Akihiro , Ishida Masami , Urano Naoto 
Published: November 2015

ABSTRACT

Olleya
sp. ITB9 is a benzo[
a
]pyrene-degrading bacterium, isolated from surface water near a waste treatment plant at Tokyo Bay, Japan. Here, we present the draft genome sequence of this strain, which consists of 58 contigs corresponding to 3.4 Mb and a G+C content of 31.2%.
Draft Genome Sequence of Thermus scotoductus Strain K1, Isolated from a Geothermal Spring in Karvachar, Nagorno Karabakh
Authors: Saghatelyan Ani , Poghosyan Lianna , Panosyan Hovik , Birkeland Nils-Kåre 
Published: November 2015

ABSTRACT

The 2,379,636-bp draft genome sequence of
Thermus scotoductus
strain K1, isolated from geothermal spring outlet located in the Karvachar region in Nagorno Karabakh is presented. Strain K1 shares about 80% genome sequence similarity with
T. scotoductus
strain SA-01, recovered from a deep gold mine in South Africa.
Experience based co-design reduces formal complaints on an acute mental health ward
Authors: Springham Neil , Robert Glenn 
Published: November 2015

AbstractAn acute mental health triage ward at Oxleas NHS Foundation Trust was attracting high levels of formal service user and family complaints. The Trust used experience based co-design to examine the issues and redesign procedures. This resulted in an immediate eradication of formal complaints for a period of 23 months. This paper describes two outcomes: firstly, the successful adaptations made to the experience based co-design methodology from its origins in physical care, in order to ensure it was safe and effective in an acute mental health setting; and, secondly, the changes made to the ward as a result of this quality improvement intervention.
Factors associated with pain coping and catastrophising in patients with systemic lupus erythematosus: a cross-sectional study of the LuLa-cohort
Authors: Fischin Julia , Chehab Gamal , Richter Jutta G , Fischer-Betz Rebecca , Winkler-Rohlfing Borgi , Willers Reinhart , Schneider Matthias 
Published: November 2015

ObjectiveThe aim of this study was to identify factors associated with pain coping and catastrophising in patients with systemic lupus erythematosus.MethodsAll patients were participants of the lupus erythematosus long-term study, which is based on patient-reported data assessed among members of the German Lupus Erythematosus Self-Help Organization. Assessments were performed by means of a questionnaire. Among self-reported clinical data the Pain-Related Self Statements Scale (PRSS) was included. To depict significant differences univariable analyses were carried out using non-parametrical rank tests. To examine factors influencing our outcome variables, we performed a multivariable stepwise regression model including variables that presented significantly in the univariable analysis.Results447 cases (94.9% female) were analysed showing a mean catastrophising score of 1.1 (SD 0.8) and a mean coping score of 2.8 (SD 0.9) in the PRSS subscales. Higher catastrophising quartiles went along with higher experienced pain, lupus activity, fatigue, damage and decreased health related quality of life, whereas they presented inversely for coping. In our multivariable model, factors associated with catastrophising were: number of lupus-specific drugs (p value 0.004), pain in the last 7 days (p value 0.034), the Short Form 12 Health Survey Mental Component Summary (p value <0.001) and disease activity measured by the Systemic Lupus Activity Questionnaire (p value 0.042). Social participation reflected by performed leisure activities such as dancing or bowling had a positive association with coping (p value 0.006). In contrast, other health related physical activities and their extent had no impact on coping. A direct association between the amount of pain coping and catastrophising, as well as a great impact of the catastrophising, respectively, coping level on physical and mental functioning could be shown.ConclusionsReduction or increase of detected factors might lead to a modification of pain coping and catastrophising and offer an approach to more effective care in patients with SLE.
SIGecom job market candidate profiles 2016
Authors: Dughmi Shaddin , Gkatzelis Vasilis , Hartline Jason 
Published: November 2015

In the sixteen years since the inception of EC as the flagship conference of the SIGecom community, we have learned a lot about the efficiency (or lack thereof) of markets. We have studied markets for school choice, marriage, supply chains, advertising, etc. We understand the loss in welfare from decentralized versus centralized market mechanisms. We understand that information plays an important role in market efficiency and stability. Profiled herein are thirty candidates for the 2016 junior academic job market with research areas that span the interest of the SIGecom community. Though it may not be a complete list, we hope that it will help alleviate some of the informational inefficiencies in the most important market for the community, its junior faculty job market.
A table of contents lists the candidates in alphabetical order with keywords they provided. The candidate profiles are listed with brief biographies, research summaries, and three representative papers. Following the candidate profiles is an index of the candidates by keywords.
Hormonal and Reproductive Factors and Risk of Myeloproliferative Neoplasms in Postmenopausal Women
Authors: Leal Alexis D. , Thompson Carrie A. , Wang Alice H. , Vierkant Robert A. , Habermann Thomas M. , Ross Julie A. , Mesa Ruben A. , Virnig Beth A. , Cerhan James R. 
Published: November 2015

AbstractBackground: Hormonal and reproductive history has been associated with risk of some hematologic malignancies, but their role in myeloproliferative neoplasms (MPN) is largely unknown.Methods: Using a population-based cohort study, we evaluated the association of these factors with risk of MPN overall, and for essential thrombocythemia (ET) and polycythemia vera (PV) specifically. Incident MPN cases from 1993 to 2004 were identified via linkage to Medicare. RR and 95% confidence intervals (CI) were estimated utilizing Cox proportional hazard regression.Results: After &gt;250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV). Ever use of hormone therapy (HT) was associated with an increased risk of ET (RR = 1.63; 95% CI, 1.19–2.23) but a decreased risk of PV (RR = 0.58; 95% CI, 0.34–0.98). There were no statistically significant associations of oral contraceptives or reproductive factors with MPN risk overall, or by MPN subtype. Bilateral oophorectomy was associated with increased risk of ET (RR = 1.58; 95% CI, 1.11–2.25) and decreased risk of PV (RR = 0.32; 95% CI, 0.12–0.88). There was no association of ovulatory years with ET risk; however, there was increased risk of PV (RR = 1.68 for &gt;36.8 compared with ≤27.6 years; P trend = 0.045). Adjustment for potential confounding factors did not alter these associations.Conclusions: HT use and bilateral oophorectomy had opposite associations for ET and PV. Except for ovulatory years and PV risk, reproductive history did not appear to play a role in the etiology of MPN.Impact: This study suggests different mechanistic impacts of estrogen, and perhaps distinct etiologies, for the two major MPN subtypes. Cancer Epidemiol Biomarkers Prev; 25(1); 151–7. ©2015 AACR.
Short Peptide Vaccine Induces CD4+ T Helper Cells in Patients with Different Solid Cancers
Authors: Gross Stefanie , Lennerz Volker , Gallerani Elisa , Mach Nicolas , Böhm Steffen , Hess Dagmar , von Boehmer Lotta , Knuth Alexander , Ochsenbein Adrian , Gnad-Vogt Ulrike , Forssmann Ulf , Woelfel Thomas , Kaempgen Eckhart 
Published: November 2015

AbstractPrevious cancer vaccination trials often aimed to activate CD8+ cytotoxic T-cell (CTL) responses with short (8–10mer) peptides and targeted CD4+ helper T cells (TH) with HLA class II–binding longer peptides (12–16 mer) that were derived from tumor antigens. Accordingly, a study of immunomonitoring focused on the detection of CTL responses to the short, and TH responses to the long, peptides. The possible induction of concurrent TH responses to short peptides was widely neglected. In a recent phase I vaccination trial, 53 patients with different solid cancers were vaccinated with EMD640744, a cocktail of five survivin-derived short (9- or 10-mer) peptides in Montanide ISA 51VG. We monitored 49 patients and found strong CD8+ T-cell responses in 63% of the patients. In addition, we unexpectedly found CD4+ TH cell responses against at least two of the five short peptides in 61% (23/38) of the patients analyzed. The two peptides were recognized by HLA-DP4– and HLA-DR–restricted TH1 cells. Some short peptide–reactive (sp)CD4 T cells showed high functional avidity. Here, we show that a short peptide vaccine is able to activate a specific CD4+ T-cell repertoire in many patients, facilitating a strong combined CD4+/CD8+ T-cell response. Cancer Immunol Res; 4(1); 18–25. ©2015 AACR.