bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibitory effect of single and repeated doses of nilotinib on the pharmacokinetics of CYP3A substrate midazolam
Authors: Zhang Hefei , Sheng Jennifer , Ko Jin H. , Zheng Cheng , Zhou Wei , Priess Petra , Lin Wen , Novick Steven 
Published: November 2014

AbstractEffects of single and repeated doses of nilotinib on the pharmacokinetics of midazolam, a cytochrome P450 3A (CYP3A) substrate, were assessed in 2 separate studies. In the single‐dose nilotinib study, 18 healthy subjects were randomized to 6 treatment sequences to receive single dose of nilotinib 600 mg, midazolam 4 mg, and coadministration of both in a crossover manner. In the repeated‐dose nilotinib study, 19 chronic myeloid leukemia patients took a single dose of midazolam 2 mg on days 1 and 13, and nilotinib 400 mg twice daily from days 2–13. In the single‐dose study, the geometric mean ratio of the area under the plasma concentration time curve extrapolated to infinity (AUCinf) of midazolam plus nilotinib vs. midazolam was 1.3 (90%CI, 1.2–1.5) and the maximum observed serum concentration (Cmax) was 1.2 (90%CI, 1.0–1.4). In the repeated‐dose study, the values for AUCinf and Cmax were 2.6 (90%CI, 2.1–3.3) and 2.0 (90%CI, 1.7–2.4), respectively. These results indicate that single‐dose and repeated‐dose administration of nilotinib results in weak and moderate inhibition of CYP3A, respectively. Therefore, appropriate monitoring and dose adjustment may be needed for drugs that are mainly metabolized by CYP3A, and have narrow therapeutic index, when coadministered with nilotinib.
Dual mobility bearings withstand loading from steeper cup‐inclinations without substantial wear
Authors: Loving LaQuawn , Herrera Lizeth , Banerjee Samik , Heffernan Christopher , Nevelos Jim , Markel David C. , Mont Michael A. 
Published: November 2014

ABSTRACTSteep cup abduction angles with adverse joint loading may increase traditional polyethylene bearing wear in total hip arthroplasties. However, there have been few reports evaluating the effect of cup inclination on the wear of dual‐mobility devices. In a hip joint simulation, we compared the short‐term wear of two‐sizes of modular highly cross‐linked dual‐mobility bearings (28 mm femoral head diameter/42 mm polyethylene insert outer diameter/54 mm acetabular shell diameter; 22.2 mm femoral head diameter/36 mm polyethylene insert outer diameter/48 mm acetabular shell diameter) at 50 and 65° of cup inclination with modular 28 mm femoral head on 54 mm cup diameter metal‐on‐highly cross‐linked polyethylene bearings. Increasing inclination from 50–65° had no changes in volumetric wear of 28/42/54 mm (mean, 1.7 vs. 1.2 mm3/million cycles, respectively; p = 0.50) and 22.2/36/48 mm (mean, 1.7 vs. 1.2 mm3/million cycles, respectively; p = 0.48) dual mobility bearings. At 65°, 22.2/36/48 mm dual‐mobility bearings had lower volumetric loss (mean, 2.2 vs. 6.3 mm3; p = 0.03) and wear rates (mean, 1.2 vs. 2.7 mm3/million cycles; p = 0.02) compared to metal‐on‐highly cross‐linked polyethylene bearings. Modern‐generation dual‐mobility designs with highly cross‐linked polyethylenes may potentially withstand edge‐loading from steeper cup‐inclinations without substantial decreases in wear. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:???–???, 2015.
Evaluation of prophylaxis treatment of Candida in alaryngeal patients with tracheoesophageal voice prostheses
Authors: Messing Barbara P. , Kim Melissa , Hirata Richard , Thompson Carol B. , Gebhart Samantha , Sugar Elizabeth A. , Saunders John M. , Sciubba James , Califano Joseph A. 
Published: November 2014

Objectives/HypothesisThe objective of this study was to evaluate the effectiveness of nystatin and Biotène® mouthwash Oral Rinse for controlling Candida in total laryngectomy (TL) patients with a tracheosophageal voice prosthesis (TEP) because Biotène® mouthwash Oral Rinse is a less costly alternative to nystatin and requires less adherence time.Study DesignRandomized, unblinded, crossover trial.MethodsTwenty‐one TL patients were randomized to receive nystatin followed by Biotène® mouthwash Oral Rinse, or the reverse order, after a basic oral‐care phase (i.e., brushing teeth, cleaning dentures). A Provox® 2, 22.5 French TEP, which is an indwelling silicone voice prosthesis, was placed at the beginning of each phase. Patients were provided with oral care instructions at randomization and medication‐specific instructions with each treatment's initiation. TEPs were processed and evaluated for Candida growth as colony‐forming units (CFUs). Wilcoxon signed‐rank tests were used for comparisons between treatments.ResultsFifteen patients were available for comparisons of Candida counts (6 received nystatin; 9 received Biotène® mouthwash first). Overall, the median log10 (CFUs) remained high regardless of treatment (no medication: 8.9; nystatin: 8.7; Biotène® mouthwash: 8.4). However, the median counts for both nystatin and Biotène® mouthwash Oral Rinse were lower than those for no medication (difference [Δ]:−0.9 and −0.3, respectively), although only nystatin was significantly lower (P = 0.02). There was no significant difference between the two treatments (P = 0.22). Overall, median medication‐adherence was high (97%), and Biotène® mouthwash adherence was significantly higher than that of nystatin (Δ: 7.6%; P = 0.03).ConclusionNystatin and Biotène® mouthwash Oral Rinse had similar CFU levels, with nystatin showing a significant improvement over usual oral care. Biotène® mouthwash is a less costly alternative to nystatin, with a less complex treatment protocol that might make it preferable to patients and clinicians.Level of Evidence1b Laryngoscope, 125:1118–1123, 2015
Systematic review of outcomes following observational and operative endoscopic middle ear surgery
Authors: Kozin Elliott D. , Gulati Shawn , Kaplan Alyson B. , Lehmann Ashton E. , Remenschneider Aaron K. , Landegger Lukas D. , Cohen Michael S. , Lee Daniel J. 
Published: November 2014

ObjectivesMiddle ear surgery increasingly employs endoscopes as an adjunct to or replacement for the operative microscope. We provide a systematic review of endoscope applications in middle ear surgery with an emphasis on outcomes, including the need for conversion to microscope, audiometric findings, length of follow‐up, as well as disease‐specific outcomes.Data SourcesPubMed, Embase, and Cochrane CENTRAL database.MethodsA literature review was performed using the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis recommendations. Articles were categorized based on study design, indication, and use of an endoscope either as an adjunct to or as a replacement for a microscope. Qualitative and descriptive analyses of studies and outcomes data were performed.ResultsOne‐hundred three articles met inclusion and exclusion criteria. Of the identified articles, 38 provided outcomes data. The majority of these studies were moderate quality, retrospective, case‐series reports. The indications for use of the endoscope were broad, with the most common being resection of cholesteatoma. In cholesteatoma surgery, endoscope approaches routinely identified residual cholesteatoma in primary and second‐look cases. Other outcomes, including robust audiometric data, operating room times, wound healing, and quality of life surveys were not well described.ConclusionsEndoscopes have consistently been used as an adjunct to the microscope to improve visualization of the tympanic cavity. Recent reports utilize the endoscope exclusively during surgical dissection; however, data comparing patient outcomes following the use of an endoscope to a microscope are lacking. Areas in need of additional research are highlighted.Level of EvidenceNA Laryngoscope, 125:1205–1214, 2015
Benchmarking a Wide Range of Chemical Descriptors for Drug‐Target Interaction Prediction Using a Chemogenomic Approach
Authors: Sawada Ryusuke , Kotera Masaaki , Yamanishi Yoshihiro 
Published: November 2014

AbstractThe identification of drug‐target interactions, or interactions between drug candidate compounds and target candidate proteins, is a crucial process in genomic drug discovery. In silico chemogenomic methods are recently recognized as a promising approach for genome‐wide scale prediction of drug‐target interactions, but the prediction performance depends heavily on the descriptors and similarity measures of drugs and proteins. In this paper, we investigated the performance of various descriptors and similarity measures of drugs and proteins for the drug‐target interaction prediction using a chemogenomic approach. We compared the prediction accuracy of 18 chemical descriptors of drugs (e.g., ECFP, FCFP,E‐state, CDK, KlekotaRoth, MACCS, PubChem, Dragon, KCF‐S, and graph kernels) and 4 descriptors of proteins (e.g., amino acid composition, domain profile, local sequence similarity, and string kernel) on about one hundred thousand drug‐target interactions. We examined the combinatorial effects of drug descriptors and protein descriptors using the same benchmark data under several experimental conditions. Large‐scale experiments showed that our proposed KCF‐S descriptor worked the best in terms of prediction accuracy. The comparative results are expected to be useful for selecting chemical descriptors in various pharmaceutical applications.
Clustering of 3D‐Structure Similarity Based Network of Secondary Metabolites Reveals Their Relationships with Biological Activities
Authors: Ohtana Yuki , Abdullah Azian Azamimi , Altaf‐Ul‐Amin Md. , Huang Ming , Ono Naoaki , Sato Tetsuo , Sugiura Tadao , Horai Hisayuki , Nakamura Yukiko , Morita (Hirai) Aki , Lange Klaus W. , Kibinge Nelson K. , Katsuragi Tetsuo , Shirai Tsuyoshi , Kanaya Shigehiko 
Published: November 2014

AbstractDeveloping database systems connecting diverse species based on omics is the most important theme in big data biology. To attain this purpose, we have developed KNApSAcK Family Databases, which are utilized in a number of researches in metabolomics. In the present study, we have developed a network‐based approach to analyze relationships between 3D structure and biological activity of metabolites consisting of four steps as follows: construction of a network of metabolites based on structural similarity (Step 1), classification of metabolites into structure groups (Step 2), assessment of statistically significant relations between structure groups and biological activities (Step 3), and 2‐dimensional clustering of the constructed data matrix based on statistically significant relations between structure groups and biological activities (Step 4). Applying this method to a data set consisting of 2072 secondary metabolites and 140 biological activities reported in KNApSAcK Metabolite Activity DB, we obtained 983 statistically significant structure group‐biological activity pairs. As a whole, we systematically analyzed the relationship between 3D‐chemical structures of metabolites and biological activities.
Can metabolically healthy obesity be explained by diet, genetics, and inflammation?
Authors: Navarro Estanislau , Funtikova Anna N. , Fíto Montserrat , Schröder Helmut 
Published: November 2014

A substantial proportion of obese individuals do not present cardiometabolic complications such as diabetes, hypertension, or dyslipidemia. Some, but not all, prospective studies observe similar risk of cardiovascular events and all‐cause mortality among individuals with this so‐called “metabolically healthy obese” (MHO) phenotype, compared to the metabolically healthy normal weight or metabolically healthy non‐obese phenotypes. Compared to the metabolically unhealthy obese (MUO) phenotype, MHO is often characterized by a more favorable inflammatory profile, less visceral fat, less infiltration of macrophages into adipose tissue, and smaller adipocyte cell size. Tipping the inflammation balance in adipose tissue might be particularly important for metabolic health in the obese. While the potential role of genetic predisposition or lifestyle factors such as diet in the MHO phenotype is yet to be clarified, it is well known that diet affects inflammation profile and contributes to the functionality of adipose tissue. This review will discuss genetic predisposition and the molecular mechanisms underlying the potential effect of food on the development of the metabolic phenotype characteristic of obesity.
Pre‐ and postcontrast T1 and T2 mapping of patellar cartilage in young adults with recurrent patellar dislocation
Authors: Bengtsson Moström Eva , Lammentausta Eveliina , Finnbogason Thröstur , Weidenhielm Lars , Janarv Per‐Mats , Tiderius Carl Johan 
Published: November 2014

PurposeTo examine the cartilage quality in young adults with recurrent patellar dislocation in childhood using different magnetic resonance imaging parameters.MethodsSixteen young adults with unilateral recurrent patellar dislocation were investigated ≥5 y (mean, 8.5 y) after the first dislocation. Pre‐ and postcontrast T1 and precontrast T2 relaxation times were analyzed in four superficial and four deep patellar cartilage regions of both knees. Two hours after intravenous injection of 0.2 mM/kg Gd‐DTPA2−, postcontrast T1 [T1(Gd)] and ΔR1 [1/T1 (precontrast) − 1/T1 (postcontrast)] were analyzed in the regions. Muscle performance and patient‐reported outcome were evaluated.ResultsWhen comparing the injured side with the noninjured side, differences were seen in the superficial half but not the deep half of the cartilage. T1(Gd) was shorter in the central part, whereas T2 was shorter in the periphery of the patellar cartilage (P < 0.05). ΔR1 demonstrated similar differences between healthy and diseased cartilage as T1(Gd) alone. The knee function was not correlated to the degenerative changes.ConclusionThe short T1(Gd) centrally indicates degenerative cartilage changes consistent with loss of glycosaminoglycans. Precontrast and ΔR1 calculations may be excluded in clinical dGEMRIC, which simplifies the procedure. A decrease in T2 may be a very early sign of joint pathology but warrants further investigation. Magn Reson Med 74:1363–1369, 2015. © 2014 Wiley Periodicals, Inc.
Demonstration of the monolithic interconnection on CIS solar cells by picosecond laser structuring on 30 by 30 cm2 modules
Authors: Heise Gerhard , Börner Andreas , Dickmann Marcel , Englmaier Marina , Heiss Andreas , Kemnitzer Matthias , Konrad Jan , Moser Regina , Palm Jörg , Vogt Helmut , Huber Heinz P. 
Published: November 2014

AbstractIn this paper, we present the selective structuring of all three patterns (P1, P2 and P3) of a monolithic interconnection of CIS (Cu(In,Ga)(S,Se)2) thin film solar cells by picosecond laser pulses at a wavelength of 1064 nm. We show results for single pulse ablation threshold values and line scribing of molybdenum films on glass (P1), CIS on molybdenum (P2) and zinc oxide on CIS (P3). The purposes of these processes are the p‐type isolation (P1), cell interconnect (P2) and n‐type isolation (P3), which are required for complete cell architecture. The half micron thick molybdenum back electrode can be structured with a process speed of more than 15 m/s at about 15 W average power without detectable residues and damage by direct induced laser ablation from the back side (P1). The CIS layer can be structured selectively down to the molybdenum at process speeds up to 1 m/s at about 15 W average power, due to the precision of direct laser ablation in the ultrashort pulse regime (P2). The ZnO front electrode layer is separated by clean trenches with straight side walls at process speeds of up to 15 m/s at about 10 W average power, as a result of indirect induced laser ablation (P3). A validation of functionality of all processes is demonstrated on CIS solar cell modules (30 × 30 cm2). By replacing one state‐of‐the‐art process by a picosecond laser process at a time, solar efficiencies could be increased for P1 and P2 and stayed on a similar level for P3. After an optimization of the patterning processes in the R&D pilot line of AVANCIS, we achieved a new record efficiency for an all‐laser‐patterned CIS solar module: 14.7% as best value for the aperture area efficiency of a 30 × 30 cm2 sized CIS module was reached. Copyright © 2014 John Wiley & Sons, Ltd.
The new MWCNTs–rhenium nanocomposite
Authors: Dobrzańska‐Danikiewicz Anna D. , Wolany Weronika , Benke Grzegorz , Rdzawski Zbigniew 
Published: November 2014

AbstractA new nanocomposite was fabricated during the undertaken research efforts, consisting of carbon nanotubes and rhenium nanoparticles. Its structure was examined using transmission electron microscopy (TEM) and the structure modification was confirmed using Raman spectroscopy. Energy dispersive spectroscopy (EDS) was employed to determine the chemical composition of the nanocomposite obtained. Carbon nanotubes with the diameter of 10–20 nm and the length of 10–30 µm, fabricated with the chemical catalytic vapor deposition (CCVD) method, were utilized for the experiment. A fabrication process of the carbon nanocomposite was started with functionalization of multi‐walled carbon nanotubes by oxidization, and then they were placed in a medium containing rhenium precursors. The mixture was further filtered and placed in a heat‐resistant vessel. Rhenium nanocrystals were deposited permanently on carbon nanotubes as a result of a high‐temperature reduction process in the atmosphere of hydrogen and in the shield of inert gas.
Exploiting array manipulation habits to optimize garbage collection and type flow analysis
Authors: Colnet Dominique , Sonntag Benoît 
Published: November 2014

SUMMARYA widespread practice to implement a flexible array is to consider the storage area into two parts: the used area, which is already available for read/write operations, and the supply area, which is used in case of enlargement of the array. The main purpose of the supply area is to avoid as much as possible the reallocation of the whole storage area in case of enlargement. As the supply area is not used by the application, the main idea of the paper is to convey the information to the garbage collector, making it possible to avoid completely the marking of the supply area. We also present a simple method to analyze the types of objects, which are stored in an array as well as the possible presence of NULL values within the array. This allows us to better specialize the work of the garbage collector when marking the used area, and also, by transitivity, to improve overall results for type analysis of all expressions of the source code. After introducing several abstract data types, which represent the main arrays concerned by our technique (i.e., zero or variable indexing, circular arrays and hash maps), we measure its impact during the bootstrap of two compilers whose libraries are equipped with these abstract data types. We then measure, on various software products we have not written, the frequency of certain habits of manipulation of arrays, to assess the validity of our approach. Copyright © 2014 John Wiley & Sons, Ltd.
Association of the duration of residence with obesity-related eating habits and dietary patterns among Latin-American immigrants in Spain
Authors: Marín-Guerrero A. C. , Rodríguez-Artalejo Fernando , Guallar-Castillón P. , López-García Esther , Gutiérrez-Fisac Juan L. 
Published: November 2014

The dietary patterns of immigrants usually change with the duration of residence and progressively resemble those of the host country. However, very few studies have investigated individuals migrating to countries with a high-quality diet, such as the Mediterranean diet (MD), and none has yet focused on Latin-American immigrants. The present study examined the association of the duration of residence with obesity-related eating habits and dietary patterns among Latin-American immigrants residing in Spain. A cross-sectional study was conducted in 2008–10 in a representative sample of the adult population residing in Spain. Adherence to the MD was defined as a MD Adherence Screener score ≥ 9. Analyses were conducted by including 419 individuals aged 18–64 years born in Latin-American countries. Compared with immigrants residing in Spain for < 5 years, those residing for ≥ 10 years accounted for a lower percentage of individuals who habitually ate at fast-food restaurants and never trimmed visible fat from meat. Moreover, these immigrants were found to have a lower intake of sugary beverages and a higher intake of Na, saturated fat, fibre, olive oil, vegetables and fish and to more frequently strictly adhere to the MD. A longer duration of residence in Spain was found to be associated with both healthy and unhealthy changes in some eating habits and dietary patterns among Latin-American immigrants. Some of the healthy changes observed contrasted the ‘Westernisation’ of the diet reported in studies conducted in other Western countries. The results of the present study support the role of the food environment of the host country in the modification of the dietary patterns of immigrants.
Clinical efficacy of tinnitus retraining therapy and cognitive behavioural therapy in the treatment of subjective tinnitus: a systematic review
Authors: Grewal R , Spielmann P M , Jones S E M , Hussain S S M 
Published: November 2014

AbstractObjective:This study aimed to compare the outcomes of two frequently employed interventions for the management of tinnitus: tinnitus retraining therapy and cognitive behavioural therapy.Method:A systematic review of literature published up to and including February 2013 was performed. Only randomised control trials and studies involving only human participants were included.Results:Nine high-quality studies evaluating the efficacy of tinnitus retraining therapy and cognitive behavioural therapy were identified. Of these, eight assessed cognitive behavioural therapy relative to a no-treatment control and one compared tinnitus retraining therapy to tinnitus masking therapy. Each study used a variety of standardised and validated questionnaires. Outcome measures were heterogeneous, but both therapies resulted in significant improvements in quality of life scores. Depression scores improved with cognitive behavioural therapy.Conclusion:Both cognitive behavioural therapy and tinnitus retraining therapy are effective for tinnitus, with neither therapy being demonstrably superior. Further research using standardised, validated questionnaires is needed so that objective comparisons can be made.