bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Ca2+‐activated Cl− channel, ANO1 (TMEM16A), is a double‐edged sword in cell proliferation and tumorigenesis
Authors: Qu Zhiqiang , Yao Weicheng , Yao Ruyong , Liu Xiangping , Yu Kuai , Hartzell Criss 
Published: March 2014

AbstractSince anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca2+‐activated Cl− channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO1 as a target for cancer treatment.
Dissecting Physical and Biochemical Factors of Catalytic Effectiveness in Immobilized D‐Amino Acid Oxidase by Real‐Time Sensing of O2 Availability Inside Porous Carriers
Authors: Bolivar Juan M. , Schelch Sabine , Mayr Torsten , Nidetzky Bernd 
Published: March 2014

AbstractD‐Amino acid oxidase (DAAO) presents a paragon for effective use of biocatalytic O2‐dependent transformations in fine‐chemical and pharmaceutical synthesis at the industrial scale. Solid‐supported DAAO immobilizates are applied to continuous processing, but their activity and stability are often inadequate. Targeted immobilization development is restricted by insufficient knowledge of physical and biochemical factors governing the performance of heterogeneous DAAO catalysts. We have applied real‐time optical sensing of the O2 availability in luminescence‐labeled porous Sepabeads and ReliSorb carriers to quantify diffusional restrictions in DAAO immobilizates differing in the mode of enzyme attachment to the solid surface. We show that noncovalent oriented immobilization of DAAO (from Trigonopsis variabilis) resulted in high retention of the original enzyme activity (≥60 %), whereas covalent multipoint fixation caused massive (up to 90 %) activity loss. Depletion of O2 inside the solid immobilizates became limiting for enzyme catalytic effectiveness at activity loadings as low as 5 units gcarrier−1. Slow pore diffusion was principally responsible for the observed large mass‐transfer resistance, and this provides a main starting point for process intensification.
Stability and CO2 Capture Ability of Electrogenerated N‐Heterocyclic Carbene in Parent 1‐Butyl‐3‐methylimidazoliun Ionic Liquid (BMIm‐X): The Role of X−
Authors: Feroci Marta , Chiarotto Isabella , Forte Gianpiero , Vecchio Ciprioti Stefano , Inesi Achille 
Published: March 2014

AbstractThe electrochemical reduction of imidazolium‐based ionic liquids (BMIm‐X) leads to the formation of corresponding N‐heterocyclic carbenes (NHCs). Owing to the peculiar reactivity of NHCs, solutions containing NHC in ionic liquid (IL) can be used in CO2 capture or in organocatalyzed reactions. It is thus important to know the stability of the carbene in the parent IL. In fact, the NHC lifetime can be influenced by the nature of the anion (X−) of the IL. To better understand the relationship between NHC lifetime (and reactivity towards CO2) and IL medium, the presence of electrogenerated NHC in the parent IL is studied by using voltammetric, infrared, and thermogravimetric analyses and by isolation of the adduct between NHC and benzaldehyde. It is thus possible to estimate the actual NHC concentration and its lifetime through voltammetric peak‐current measurements. Moreover, NHC in BMIm‐X is able to catch CO2 (yielding the adduct NHC–CO2) and, triggered by heating (60‐150 °C), to release CO2. It is proven that the half‐life of NHC and the rate of CO2 capture are both affected by the nature of X−.
Solid‐State Interconversions: Unique 100 % Reversible Transformations between the Ground and Metastable States in Single‐Crystals of a Series of Nickel(II) Nitro Complexes
Authors: Warren Mark R. , Easun Timothy L. , Brayshaw Simon K. , Deeth Robert J. , George Michael W. , Johnson Andrew L. , Schiffers Stefanie , Teat Simon J. , Warren Anna J. , Warren John E. , Wilson Chick C. , Woodall Christopher H. , Raithby Paul R. 
Published: March 2014

AbstractThe solid‐state, low‐temperature linkage isomerism in a series of five square planar group 10 phosphino nitro complexes have been investigated by a combination of photocrystallographic experiments, Raman spectroscopy and computer modelling. The factors influencing the reversible solid‐state interconversion between the nitro and nitrito structural isomers have also been investigated, providing insight into the dynamics of this process. The cis‐[Ni(dcpe)(NO2)2] (1) and cis‐[Ni(dppe)(NO2)2] (2) complexes show reversible 100 % interconversion between the η1‐NO2 nitro isomer and the η1‐ONO nitrito form when single‐crystals are irradiated with 400 nm light at 100 K. Variable temperature photocrystallographic studies for these complexes established that the metastable nitrito isomer reverted to the ground‐state nitro isomer at temperatures above 180 K. By comparison, the related trans complex [Ni(PCy3)2(NO2)2] (3) showed 82 % conversion under the same experimental conditions at 100 K. The level of conversion to the metastable nitrito isomers is further reduced when the nickel centre is replaced by palladium or platinum. Prolonged irradiation of the trans‐[Pd(PCy3)2(NO2)2] (4) and trans‐[Pt(PCy3)2(NO2)2] (5) with 400 nm light gives reversible conversions of 44 and 27 %, respectively, consistent with the slower kinetics associated with the heavier members of group 10. The mechanism of the interconversion has been investigated by theoretical calculations based on the model complex [Ni(dmpe)Cl(NO2)].
Catalytic Water Splitting with an Iridium Carbene Complex: A Theoretical Study
Authors: Venturini Alessandro , Barbieri Andrea , Reek Joost N. H. , Hetterscheid Dennis G. H. 
Published: March 2014

AbstractCatalytic water oxidation at Ir(OH)+ (Ir=IrCp*(Me2NHC), where Cp*=pentamethylcyclopentadienyl and Me2NHC=N,N′‐dimethylimidazolin‐2‐ylidene) can occur through various competing channels. A potential‐energy surface showing these various multichannel reaction pathways provides a picture of how their importance can be influenced by changes in the oxidant potential. In the most favourable calculated mechanism, water oxidation occurs via a pathway that includes four sequential oxidation steps, prior to formation of the OO bond. The first three oxidation steps are exothermic upon treatment with cerium ammonium nitrate and lead to formation of IrV(O)(O.)+, which is calculated to be the most stabile species under these conditions, whereas the fourth oxidation step is the potential‐energy‐determining step. OO bond formation takes place by coupling of the two oxo ligands along a direct pathway in the rate‐limiting step. Dissociation of dioxygen occurs in two sequential steps, regenerating the starting material Ir(OH)+. The calculated mechanism fits well with the experimentally observed rate law: v=kobs[Ir][oxidant]. The calculated effective barrier of 24.6 kcal mol−1 fits well with the observed turnover frequency of 0.88 s−1. Under strongly oxidative conditions, OO bond formation after four sequential oxidation steps is the preferred pathway, whereas under milder conditions OO bond formation after three sequential oxidation steps becomes competitive.
Photodynamic Therapy Efficacy Enhanced by Dynamics: The Role of Charge Transfer and Photostability in the Selection of Photosensitizers
Authors: Arnaut Luis G. , Pereira Mariette M. , Dąbrowski Janusz M. , Silva Elsa F. F. , Schaberle Fábio A. , Abreu Artur R. , Rocha Luís B. , Barsan Madalina M. , Urbańska Krystyna , Stochel Grażyna , Brett Christopher M. A. 
Published: March 2014

AbstractProgress in the photodynamic therapy (PDT) of cancer should benefit from a rationale to predict the most efficient of a series of photosensitizers that strongly absorb light in the phototherapeutic window (650–800 nm) and efficiently generate reactive oxygen species (ROS=singlet oxygen and oxygen‐centered radicals). We show that the ratios between the triplet photosensitizer–O2 interaction rate constant (kD) and the photosensitizer decomposition rate constant (kd), kD/kd, determine the relative photodynamic activities of photosensitizers against various cancer cells. The same efficacy trend is observed in vivo with DBA/2 mice bearing S91 melanoma tumors. The PDT efficacy intimately depends on the dynamics of photosensitizer–oxygen interactions: charge transfer to molecular oxygen with generation of both singlet oxygen and superoxide ion (high kD) must be tempered by photostability (low kd). These properties depend on the oxidation potential of the photosensitizer and are suitably combined in a new fluorinated sulfonamide bacteriochlorin, motivated by the rationale.
A Cobalt Pyrenylnitronylnitroxide Single‐Chain Magnet with High Coercivity and Record Blocking Temperature
Authors: Vaz Maria G. F. , Cassaro Rafael A. Allão , Akpinar Handan , Schlueter John A. , Lahti Paul M. , Novak Miguel A. 
Published: March 2014

AbstractCoordination of a [Co(hfac)2] moiety (hfac=hexafluoroacetylacetonate) with a nitronylnitroxide radical linked to bulky, rigid pyrene (PyrNN) gives a helical 1:1 chain complex, in which both oxygen atoms of the radical NO. groups are bonded to CoII ions with strong antiferromagnetic exchange. The complex shows single‐chain magnet (SCM) behavior with frequency‐dependent magnetic susceptibility, field‐cooled and zero‐field‐cooled susceptibility divergence with a high blocking temperature of around 14 K (a record among SCMs), and hysteresis with a very large coercivity of 32 kOe at 8 K. The magnetic behavior is partly related to good chain isolation induced by the large pyrene units. Two magnetic relaxation processes have been observed, a slower one attributable to longer, and a faster one attributable to short chains. No evidence of magnetic ordering has been found.
Efficiently Detecting Metallodrug–Protein Adducts: Ion Trap versus Time‐of‐Flight Mass Analyzers
Authors: Meier Samuel M. , Babak Maria V. , Keppler Bernhard K. , Hartinger Christian G. 
Published: March 2014

AbstractModern mass spectrometry techniques have increasingly found use in studies on the binding of anticancer metallodrugs to potential cellular targets. In this context, investigations on the detection efficiency of adduct formation between antiproliferative Ru(arene) complexes and proteins in dependence of the mass analyzer used in the electrospray ionization (ESI) mass spectrometer are presented. The potential in detecting adducts between the metal center and the protein was found to be dependent on the mass analyzer and the denticity of the metal–protein interaction. This might be related to the design of the mass analyzers with different conditions in the ion travelling pathways, which affects adducts when the protein acts as a monodentate ligand more highly than in cases when the protein is a multidentate ligand. This could also impact the biological activity and indicate different pathways of metabolism of biomolecule adducts.
Adherence and retention in clinical trials: A community‐based approach
Authors: Fouad Mona N. , Johnson Rhoda E. , Nagy M. Christine , Person Sharina D. , Partridge Edward E. 
Published: March 2014

BACKGROUNDThe Community Health Advisor (CHA) model has been widely used to recruit rural and low‐income, mostly African American women into clinical and behavioral research studies. However, little is known about its effectiveness in promoting retention and adherence of such women in clinical trials.METHODSThe Community‐Based Retention Intervention Study evaluated the effectiveness of a community‐based intervention strategy using the CHA model and the empowerment theory to improve the retention and adherence of minority and low‐income women in clinical trials. The research strategy included the training and use of the volunteer CHAs as research partners. The target population included women participating in the University of Alabama at Birmingham clinical site of the Atypical Squamous Cells of Undetermined Significance–Low‐Grade Squamous Intraepithelial Lesion (ASCUS‐LSIL) Triage Study (ALTS), a multicenter, randomized clinical trial. Two communities in Jefferson County, Alabama, that were matched according to population demographics were identified and randomly assigned to either an intervention group or a control group. Thirty community volunteers were recruited to be CHAs and to implement the intervention with the ALTS trial participants. In total, 632 ALTS participants agreed to participate in the project, including 359 in the intervention group, which received CHA care, and 273 in the control group, which received standard care.RESULTSAdherence rates for scheduled clinic visits were significantly higher in the intervention group (80%) compared with the control group (65%; P < .0001).CONCLUSIONSThe results indicate that volunteer CHAs can be trained to serve as research partners and can be effective in improving the retention and adherence of minority and low‐income women in clinical trials. Cancer 2014;120(7 suppl):1106–12. © 2014 American Cancer Society.
Twenty years post‐NIH Revitalization Act: Enhancing minority participation in clinical trials (EMPaCT): Laying the groundwork for improving minority clinical trial accrual
Authors: Chen Moon S. , Lara Primo N. , Dang Julie H. T. , Paterniti Debora A. , Kelly Karen 
Published: March 2014

BACKGROUNDThe National Institutes of Health (NIH) Revitalization Act of 1993 mandated the appropriate inclusion of minorities in all NIH‐funded research. Twenty years after this act, the proportion of minority patients enrolled in cancer clinical trials remains persistently low. Clinical trials are vehicles for the development and evaluation of therapeutic and preventive agents under scientifically rigorous conditions. Without representation in trials, it is projected that disparities in the cancer burden for minorities will increase.METHODSFor this review article, the authors counted the frequency with which minorities were the primary focus of National Cancer Institute‐sponsored clinical trials, examined citations from the PubMed database focusing on the search terms “NIH Revitalization Act of 1993” and “enhancing minority accrual to cancer clinical trials,” and supplemented the review with their expertise in NIH‐funded research related to minority accrual in cancer clinical trials.RESULTSThe reporting and analyses of data based on minorities in clinical trials remain inadequate. Less than 2% of the National Cancer Institute's clinical trials focus on any racial/minority population as their primary emphasis. The current review of the literature indicated that the percentage of authors who reported their study sample by race/ethnicity ranged from 1.5% to 58%, and only 20% of the randomized controlled studies published in a high‐impact oncology journal reported analyzing results by race/ethnicity. Proportionately greater population increases in minorities, accompanied by their persistent and disproportionate cancer burden, reinforce the need for their greater representation in clinical trials.CONCLUSIONSRenewing the emphasis for minority participation in clinical trials is warranted. Policy changes are recommended. Cancer 2014;120(7 suppl):1091–6. © 2014 American Cancer Society.
Underestimation of myelodysplastic syndrome incidence by cancer registries: Results from a population‐based data linkage study
Authors: McQuilten Zoe K. , Wood Erica M. , Polizzotto Mark N. , Campbell Lynda J. , Wall Meaghan , Curtis David J. , Farrugia Helen , McNeil John J. , Sundararajan Vijaya 
Published: March 2014

BACKGROUNDMyelodysplastic syndromes (MDS) appear to be underreported to cancer registries, with important implications for cancer and transfusion support service planning and delivery. Two population‐based databases were linked to estimate MDS incidence more accurately.METHODSData from the statewide Victorian Cancer Registry (VCR) and Victorian Admitted Episode Dataset (VAED, capturing all inpatient admissions), in Australia, were linked. Incidence rates were calculated based on VCR reported cases and using additional MDS cases identified in VAED. Differences between reported and nonreported cases were assessed. A multivariate capture‐recapture method was used to estimate missed cases.RESULTSBetween 2003 and 2010, 2692 cases were reported to VCR and an additional 1562 cases were identified in VAED. Annual incidence rate for those aged 65 years and older based on VCR was 44 per 100,000 (95% confidence interval [CI] = 43‐45 per 100,000) and 68 per 100,000 (95% CI = 67‐70 per 100,000) using both data sets. Cases not reported to VCR were more likely to have had previous malignancies recorded in VAED (23% versus 19%, P = .003) and to require red cell transfusion (59% versus 54%, P = .003). Using the multivariate model, an estimated 1292 cases were missed by both data sources: the re‐estimate was 5546 (95% CI = 5438‐5655) MDS cases, with an annual incidence in those aged 65 or older of 103 per 100,000 (95% CI = 100‐106).CONCLUSIONSThis study reports a higher incidence of MDS using 2 data sources from a large and well‐defined population than reported using cancer registry notifications alone. Cancer 2014;120:1686–1694. © 2014 American Cancer Society.
Experiences of the Brazilian national high‐performance computing network on the rapid prototyping of science gateways
Authors: Gomes Antonio Tadeu A. , Bastos Bruno F. , Medeiros Vivian , Moreira Vinicius M. 
Published: March 2014

SummaryArguably, an important amount of scientific software development time is likely to be employed on user interfaces. In particular, science gateways have gained increasing interest from the e‐Science community. These gateways allow hiding the complexity of the underlying resources that give support to the management of scientific data and to the execution of scientific applications. Based on our previous experience with the development of science gateways for diverse application domains in the Brazilian national high‐performance computing network (SINAPAD), we have devised a rapid prototyping strategy to lower the barrier for scientific application developers to launch new science gateways. This strategy is based on two main tools. The first tool implements a gateway engine that can be configured by a small set of XML files. Such files completely define the desired functionality of a specific science gateway in the gateway engine. The gateway engine also offers other features not commonly found in related technologies, such as file sharing, data provenance tracking, and restricted anonymous access to underlying computational resources. The second tool implements both an editor and a packager for the aforementioned engine. This tool allows the developer to rapidly deploy and launch a new science gateway in ordinary Web application containers. In this paper, we present our results with the use of both tools in the SINAPAD network. We also discuss about the current limitations of both tools, as well as how we have been dealing with such limitations to provide a more comprehensive toolset to developers. Copyright © 2014 John Wiley & Sons, Ltd.
CdSe–Graphene Oxide Light‐Harvesting Assembly: Size‐Dependent Electron Transfer and Light Energy Conversion Aspects
Authors: Krishnamurthy Sachidananda , Kamat Prashant V. 
Published: March 2014

AbstractExcited‐state interaction between CdSe quantum dots (QDs) of different sizes (2.3, 3.2, and 4.2 nm diameter) and graphene oxide (GO) was probed by depositing them as films on conducting glass electrodes. The emission of smaller CdSe QDs (2.3 nm) was quenched by GO three times faster than that of larger QDs (4.2 nm). Electrophoretic deposition allowed us to sequentially deposit single or multiple layers of different sized QDs and GO assemblies on conducting glass electrodes and to modulate the photoresponse in photoelectrochemical solar cells. Superior photoconversion efficiency through the incorporation of GO was attributed to improved charge separation in the composite assembly.
Designing Fractal Nanostructured Biointerfaces for Biomedical Applications
Authors: Zhang Pengchao , Wang Shutao 
Published: March 2014

AbstractFractal structures in nature offer a unique “fractal contact mode” that guarantees the efficient working of an organism with an optimized style. Fractal nanostructured biointerfaces have shown great potential for the ultrasensitive detection of disease‐relevant biomarkers from small biomolecules on the nanoscale to cancer cells on the microscale. This review will present the advantages of fractal nanostructures, the basic concept of designing fractal nanostructured biointerfaces, and their biomedical applications for the ultrasensitive detection of various disease‐relevant biomarkers, such microRNA, cancer antigen 125, and breast cancer cells, from unpurified cell lysates and the blood of patients.
Flexible Janus Nanofibers: Facile Electrospinning Construction and Enhanced Luminescent–Electrical–Magnetic Trifunctionality
Authors: Lv Nan , Ma Qianli , Dong Xiangting , Wang Jinxian , Yu Wensheng , Liu Guixia 
Published: March 2014

AbstractFlexible luminescent–electrical–magnetic trifunctional Janus nanofibers have been successfully fabricated through electrospinning technology by using specially designed parallel spinnerets. The terbium complex [Tb(ba)3(phen)] (BA=benzoic acid, phen=1,10‐phenanthroline), polyaniline (PANI), and Fe3O4 nanoparticles (NPs) were incorporated into polyvinyl pyrrolidone (PVP) and electrospun into Janus nanofibers with [Tb(ba)3(phen)]/PVP as one strand of the nanofiber and PANI/Fe3O4/PVP as another. The morphologies and properties of the final products were investigated in detail by XRD, SEM, TEM, fluorescence spectroscopy, Hall effect measurement system, and vibrating sample magnetometry. The [[Tb(ba)3(phen)]/PVP]//[PANI/Fe3O4/PVP] Janus nanofibers, with an average diameter of 180 nm, simultaneously possess enhanced luminescent performance, electrical conduction, and magnetism. Fluorescence emission peaks of Tb3+ are observed in the [[Tb(ba)3(phen)]/PVP]//[PANI/Fe3O4/PVP] Janus nanofibers and assigned to the 5D4→5F6 (λ=491 nm), 5D4→5F5 (λ=544 nm), 7D4→5F4 (λ=585 nm), and 5D4→7F3 (λ=620 nm) energy‐level transitions of Tb3+ ions; the 5D4→5F5 hypersensitive transition at λ=544 nm is the predominant emission peak. The electrical conductivity of Janus nanofibers reaches up to the order of 10−3 S cm−1. The luminescent intensity, electrical conductivity, and magnetic properties of Janus nanofibers can be tunable by adjusting the amounts of rare‐earth complex, PANI, and Fe3O4 NPs present. This new type of luminescent–electrical–magnetic trifunctional Janus nanofiber holds potential for a variety of applications, including molecular electronics, microwave absorption, and future nanodevices, owing to their excellent fluorescence, electrical conduction, and magnetism.