bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma
Authors: Kurscheid Sebastian , Bady Pierre , Sciuscio Davide , Samarzija Ivana , Shay Tal , Vassallo Irene , Criekinge Wim V , Daniel Roy T , van den Bent Martin J , Marosi Christine , Weller Michael , Mason Warren P , Domany Eytan , Stupp Roger , Delorenzi Mauro , Hegi Monika E 
Published: January 2015

Abstract
Background
HOX genes are a family of developmental genes that are expressed neither in the developing forebrain nor in the normal brain. Aberrant expression of a HOX-gene dominated stem-cell signature in glioblastoma has been linked with increased resistance to chemo-radiotherapy and sustained proliferation of glioma initiating cells. Here we describe the epigenetic and genetic alterations and their interactions associated with the expression of this signature in glioblastoma.

Results
We observe prominent hypermethylation of the HOXA locus 7p15.2 in glioblastoma in contrast to non-tumoral brain. Hypermethylation is associated with a gain of chromosome 7, a hallmark of glioblastoma, and may compensate for tumor-driven enhanced gene dosage as a rescue mechanism by preventing undue gene expression. We identify the CpG island of the HOXA10 alternative promoter that appears to escape hypermethylation in the HOX-high glioblastoma. An additive effect of gene copy gain at 7p15.2 and DNA methylation at key regulatory CpGs in HOXA10 is significantly associated with HOX-signature expression. Additionally, we show concordance between methylation status and presence of active or inactive chromatin marks in glioblastoma-derived spheres that are HOX-high or HOX-low, respectively.

Conclusions
Based on these findings, we propose co-evolution and interaction between gene copy gain, associated with a gain of chromosome 7, and additional epigenetic alterations as key mechanisms triggering a coordinated, but inappropriate, HOX transcriptional program in glioblastoma.
Symptomatic Toxicities Experienced During Anticancer Treatment: Agreement Between Patient and Physician Reporting in Three Randomized Trials
Authors: Di Maio Massimo , Gallo Ciro , Leighl Natasha B. , Piccirillo Maria Carmela , Daniele Gennaro , Nuzzo Francesco , Gridelli Cesare , Gebbia Vittorio , Ciardiello Fortunato , De Placido Sabino , Ceribelli Anna , Favaretto Adolfo G. , de Matteis Andrea , Feld Ronald , Butts Charles , Bryce Jane , Signoriello Simona , Morabito Alessandro , Rocco Gaetano , Perrone Francesco 
Published: January 2015

Purpose Information about symptomatic toxicities of anticancer treatments is not based on direct report by patients, but rather on reports by clinicians in trials. Given the potential for under-reporting, our aim was to compare reporting by patients and physicians of six toxicities (anorexia, nausea, vomiting, constipation, diarrhea, and hair loss) within three randomized trials. Patients and Methods In one trial, elderly patients with breast cancer received adjuvant chemotherapy; in two trials, patients with advanced non–small-cell lung cancer received first-line treatment. Toxicity was prospectively collected by investigators (graded by National Cancer Institute Common Toxicity Criteria [version 2.0] or Common Terminology Criteria for Adverse Events [version 3]). At the end of each cycle, patients completed the European Organisation for Research and Treatment of Cancer quality-of-life questionnaires, including toxicity-related symptom items. Possible answers were “not at all,” “a little,” “quite a bit,” and “very much.” Analysis was limited to the first three cycles. For each toxicity, agreement between patients and physicians and under-reporting by physicians (ie, toxicity reported by patients but not reported by physicians) were calculated. Results Overall, 1,090 patients (2,482 cycles) were included. Agreement between patients and physicians was low for all toxicities. Toxicity rates reported by physicians were always lower than those reported by patients. For patients who reported toxicity (any severity), under-reporting by physicians ranged from 40.7% to 74.4%. Examining only patients who reported “very much” toxicity, under-reporting by physicians ranged from 13.0% to 50.0%. Conclusion Subjective toxicities are at high risk of under-reporting by physicians, even when prospectively collected within randomized trials. This strongly supports the incorporation of patient-reported outcomes into toxicity reporting in clinical trials.
Inherited NUDT15 Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia
Authors: Yang Jun J. , Landier Wendy , Yang Wenjian , Liu Chengcheng , Hageman Lindsey , Cheng Cheng , Pei Deqing , Chen Yanjun , Crews Kristine R. , Kornegay Nancy , Wong F. Lennie , Evans William E. , Pui Ching-Hon , Bhatia Smita , Relling Mary V. 
Published: January 2015

Purpose Mercaptopurine (MP) is the mainstay of curative therapy for acute lymphoblastic leukemia (ALL). We performed a genome-wide association study (GWAS) to identify comprehensively the genetic basis of MP intolerance in children with ALL. Patients and Methods The discovery GWAS and replication cohorts included 657 and 371 children from two prospective clinical trials. MP dose intensity was a marker for drug tolerance and toxicities and was defined as prescribed dose divided by the planned protocol dose during maintenance therapy; its association with genotype was evaluated using a linear mixed-effects model. Results MP dose intensity varied by race and ethnicity and was negatively correlated with East Asian genetic ancestry (P < .001). The GWAS revealed two genome-wide significant loci associated with dose intensity: rs1142345 in TPMT (Tyr240Cys, present in *3A and *3C variants; P = 8.6 × 10−9) and rs116855232 in NUDT15 (P = 8.8 × 10−9), with independent replication. Patients with TT genotype at rs116855232 were exquisitely sensitive to MP, with an average dose intensity of 8.3%, compared with those with TC and CC genotypes, who tolerated 63% and 83.5% of the planned dose, respectively. The NUDT15 variant was most common in East Asians and Hispanics, rare in Europeans, and not observed in Africans, contributing to ancestry-related differences in MP tolerance. Of children homozygous for either TPMT or NUDT15 variants or heterozygous for both, 100% required ≥ 50% MP dose reduction, compared with only 7.7% of others. Conclusion We describe a germline variant in NUDT15 strongly associated with MP intolerance in childhood ALL, which may have implications for treatment individualization in this disease.
Normal families of meromorphic mappings of several complex variables for moving hypersurfaces in a complex projective space
Authors: Dethloff Gerd , Thai Do Duc , Thu Trang Pham Nguyen 
Published: January 2015

AbstractThe main aim of this article is to give sufficient conditions for a family of meromorphic mappings of a domain D in ℂn into ℙN(ℂ) to be meromorphically normal if they satisfy only some very weak conditions with respect to moving hypersurfaces in ℙN(ℂ), namely, that their intersections with these moving hypersurfaces, which moreover may depend on the meromorphic maps, are in some sense uniform. Our results generalize and complete previous results in this area, especially the works of Fujimoto, Tu, Tu-Li, Mai-Thai-Trang, and the recent work of Quang-Tan.
N-Alkylation of Sulfonamides with Alcohols by Tf2O
Authors: Yu Ting Ting , Qi Lan-Jun , Cui Dong-Mei , Zhang Chen , Zhao Yan 
Published: January 2015

Abstract
N-sulfonylpyrrolidines and N-alkyl sulfonamides were efficiently prepared via alkylation of sulfonamides with 1,4-diols or alcohols by Tf2O. The reaction occurred under mild reaction conditions in moderate to high yields and tolerated aryl and aliphatic sulfonamides.
Nanostructure Control of Porous Carbon Materials through Changing Acidity with a Soft-template Method
Authors: Sonoda Yuki , Hayashi Akari , Minamida Yasuto , Matsuda Junko , Akiba Etsuo 
Published: January 2015

Abstract
Nanostructures of porous carbon materials were controlled by a soft-template method for expanding their applications. When 2,6-dihydropyridine hydrochloride, a nitrogen-containing compound, was used as a carbon precursor in addition to resorcinol, larger pores over 50 nm appeared besides mesopores. The condition of such large pores being formed was examined in detail, and acidity was found to be a key factor for large pores rather than the presence of nitrogen atoms.
Unique Surface Properties of Nanocomposite Thin Film Photocatalysts of TiO2 and Poly(tetrafluoroethylene)
Authors: Kamegawa Takashi , Irikawa Koichi , Yamashita Hiromi 
Published: January 2015

Abstract
Nanocomposite thin film photocatalysts of TiO2 and poly(tetrafluoroethylene) (PTFE) were prepared by applying a radio frequency magnetron sputtering deposition technique. A superhydrophobic surface, with high transparency and photocatalytic self-cleaning property, was successfully realized by the deposition of TiO2–PTFE composite on spherical SiO2-modified quartz substrate. TiO2–PTFE composite suppressed the surface wettability changes to hydrophilic state and exhibited an adequate photocatalytic activity for the removal of oleic acid as a model contaminant of oily dirt under UV light irradiation.
Nickel Catalysts/N,N′-Bidentate Directing Groups: An Excellent Partnership in Directed C–H Activation Reactions
Authors: Castro Luis C Misal , Chatani Naoto 
Published: January 2015

Abstract
This review focuses on chelation-assisted regioselective C–H activation with C–C or/and C–N bond formation using nickel(0) or -(II) as the catalysts, where bidentate directing groups play a key role in the successful transformation. A 2-pyridinylmethylamine or an 8-aminoquinoline moiety are the more powerful auxiliaries among the directing groups examined.
The endothelial deprotection hypothesis for lupus pathogenesis: the dual role of C1q as a mediator of clearance and regulator of endothelial permeability
Authors: Prechl József , Czirják László 
Published: January 2015

Systemic lupus erythematosus (SLE) is a heterogeneous multifactorial systemic autoimmune disease affecting several organs. SLE can start relatively early in life and results in impaired quality of life and shortened life expectancy because of a gradual disease progression leading to cardiovascular, renal and neoplastic disease. The basic mechanisms of the pathogenesis of the disease still remain to be clarified. It is clear that complement proteins play a key and complex role in the development of SLE. Complement component C1q has been known to be a fundamental component of lupus development, but most explanations focus on its role in apoptotic debris removal. Importantly, C1q was recently found to play a key role in the maintenance of vascular endothelial integrity.We suggest that apoptotic products, endothelial cells and extracellular matrix components, which display negatively charged moieties, compete for binding to molecules of the innate humoral immune response, like C1q. Genetic or acquired factors leading to an increased load of apoptotic cell debris and decrease or absence of C1q therefore interfere with the regulation of endothelial permeability and integrity. Furthermore, we suggest that lupus is the net result of an imbalance between the two functions of immune clearance and vascular endothelial integrity maintenance, an imbalance triggered and sustained by autoimmunity, which skews C1q consumption by IgG-mediated complement classical pathway activation on autoantigens. In this triangle of innate clearance, autoimmunity and endothelial integrity, C1q plays a central role.Hence, we interpret the pathogenesis of lupus by identifying three key components, namely innate immune clearance, autoimmunity and endothelial integrity and we establish a link between these components based on the protective role that innate clearance molecules play in endothelial renewal. By including the vasoprotective role of C1q in the interpretation of SLE development we attempt to provide novel explanations for the symptoms, organ damage, diagnostic and therapeutic difficulties of the disease.
Parental Training for Teaching Foreign Language to Preschool and Junior School Children
Authors: Ромашина  , Romashina Svetlana , Майер  , Mayer Aleksey 
Published: January 2015

Authors suggest the idea of parental training for the process of foreign-language education of preschool and junior school children. The article
reveals goals, contents and methods of work with parents who form readiness for participation in foreign-language education of their children.
Problems of continuity of foreign-language education of preschool and junior school children are discussed.
The quality of life, symptoms of depression and coping with stress among individuals with type 2 diabetes – preliminary study
Authors: Kalka Dorota 
Published: January 2015

CelCelem badania było porównanie poczucia jakości życia, występowania objawów depresji i sposobów radzenia sobie ze stresem u osób z cukrzycą typu 2 i osób zdrowych w okresie średniej dorosłości, a także weryfikacja związku wyżej wymienionych zmiennych w badanych grupach.MetodaPrzebadano 42 osoby z cukrzycą typu 2 oraz 45 osób zdrowych. Wykorzystano cztery kwestionariusze o uznanych właściwościach psychometrycznych.WynikiWykazano znaczące różnice w zakresie ogólnego poczucia jakości życia, zadowolenia ze zdrowia oraz domeny fizycznej, występowania objawów depresji, a także reaktywnego radzenia sobie ze stresem – skoncentrowanego na emocjach i unikaniu.WnioskiOsoby z cukrzycą posiadają niższe ogólne poczucie jakości życia oraz zadowolenia ze zdrowia i sfery fizycznej, a także większe nasilenie objawów depresji. W sytuacji doznawanego stresu obie grupy stosują tak samo często styl skoncentrowany na zadaniu. Osoby z cukrzycą częściej niż zdrowe stosują styl skoncentrowany na emocjach, osoby zdrowe natomiast na unikaniu. Obie grupy tak samo często stosują różne proaktywne strategie radzenia sobie.
Convergence insufficiency with unilateral exophoria at near in schizophrenia and bipolar disorder - a preliminary study
Authors: Chrobak Adrian , Siuda Katarzyna , Biela Michał , Arciszewska Aleksandra , Siwek Marcin , Pilecki Maciej , Dudek Dominika 
Published: January 2015

CelPoniższe badanie dotyczy nieprawidłowości konwergencji (Convergence Insufficiency, CI) objawiających się jednostronną egzoforią do bliży u pacjentów ze schizofrenią (SZ) i chorobą afektywną dwubiegunową (ChAD). Celem artykułu jest opis tego objawu i dyskusja jego potencjalnych przyczyn.MetodaPrzebadano 29 pacjentów ze SZ, 14 pacjentów z ChAD i 20 zdrowych osób kontrolnych (GK). Badanie neurologiczne wykonano za pomocą skal International Co-operative Ataxia Rating Scale (ICARS) i Neurological Evaluation Scale (NES).WynikiCI zaobserwowano u 12 pacjentów z SZ oraz 1 pacjenta z ChAD. Jednostronna egzoforia do bliży pojawiła się statystycznie częściej u pacjentów SZ niż u ChAD i GK, u której nie pojawił się wcale. Pacjenci z SZ prezentujący objaw uzyskali gorsze wyniki na podskalach dyzartrii i okoruchowej ICARS. Wyniki na skalach neurologicznych nie różnicowały pacjentów z ChAD i SZ.WnioskiCI może mieć związek z zaburzeniami sieci korowo-mostowo-móżdżkowej oraz struktur śródmózgowia. Jako jedyny objaw neurologiczny różnicował grupy SZ i ChAD, więc może być pomocny w diagnozie różnicowej.
Supply Management in Multiproduct Firms with Fixed Proportions Technology
Authors: Boyabatlı Onur 
Published: January 2015

This paper studies the supply management of a primary input, where this input gives rise to multiple products in fixed proportions. My objective is twofold. First, I study fixed proportions technology under demand uncertainty in comparison with the flexible and dedicated technologies. I show that fixed proportions technology has a cost-pooling value over dedicated technology, which is larger than the capacity-pooling value of flexible technology over dedicated technology. I identify the critical role that demand correlation plays with the fixed proportions technology: in contrast to the capacity-pooling value, which decreases in demand correlation, the cost-pooling value increases in demand correlation. Second, focusing on the fixed proportions technology, I study supply management in the presence of contract and spot markets. I investigate how the optimal supply management strategy should respond to changing market uncertainties, and the differences in this response based on the contract type. I find that when the exercise price of the contract is high, a higher contract market dependence is the best response to the increasing demand correlation or spot price variability. However, a lower contract market dependence is the best response to the same when the exercise price is low. Managerially, these results are important because they imply that the supply management strategy adopted as a response to a change in the business environment should differ depending on the contract type. My results have implications about the new product strategy and the procurement contract choice of the processors in the agricultural industries. This paper was accepted by Yossi Aviv, operations management.
Reviews DVD/Blu-ray
Authors: Adams Johnathan , Ebbs Dylan 
Published: January 2015

Abstract
Radical Realism: The Criterion Blu-ray Release of On the Waterfront
On the Waterfront (1954) USA Director Elia Kazan Runtime 108 minutes
Blu-ray 2013, USA Produced and Distributed by The Criterion Collection (region A/1)
The Big Lebowski (1998) USA Director Joel Coen Runtime 118 minutes
DVD USA, 2005 Produced and Distributed by Universal Studios Home Entertainment (region 1)
The one-dimensional heat equation in the Alexiewicz norm
Authors: Talvila Erik 
Published: January 2015

AbstractA distribution on the real line has a continuous primitive integral if it is the distributional derivative of a function that is continuous on the extended real line. The space of distributions integrable in this sense is a Banach space that includes all functions integrable in the Lebesgue and Henstock–Kurzweil senses. The one-dimensional heat equation is considered with initial data that is integrable in the sense of the continuous primitive integral. Let Θ
The Impact of Public Insurance on Private Insurance Demand
Authors: Okura Mahito 
Published: January 2015

Abstract
The purpose of this study is to investigate whether private insurance is a normal good by examining the effects of public insurance. Also, this study investigates how the amount of public insurance premium affects to the private insurance demand. The main results of this study are as follows. First, the private insurance has a tendency to be a normal good whether the public insurance benefit is fixed to household income. Second, the degree of loading of public insurance and average probability of accident taking place, which are the components of public insurance premium, relates to the private insurance demand, but whether this relation is positive or negative is indeterminate unless private insurance is actuarially fair.
A new robust statistical model for interpretation of differences in serial test results from an individual
Authors: Braga Federica , Ferraro Simona , Ieva Francesca , Paganoni Anna , Panteghini Mauro 
Published: January 2015

AbstractPopulation-based reference intervals have very limited value for the interpretation of laboratory results when analytes display high biological individuality. In these cases, the longitudinal evaluation of individual results using the reference change value (RCV) is the recommended approach. However, the traditional model for RCV calculation requires a Gaussian frequency distribution of data and risks to overestimate the parameter if a correlation between within-subject serial measurements is present.We propose and validate an alternative non-parametric statistical model for interpretation of differences in serial results from an individual, overcoming data distribution and correlation issues.After describing the traditional and newly proposed statistical models, we compared them with each other using a simulation on three specific analytes displaying different concentration distributions in biological setting. We demonstrated that when analyte concentrations followed a Gaussian frequency distribution, as in the case of glycated hemoglobin, both methods can be used equally. On the contrary, if analyte concentrations present a bimodal (e.g., chromogranin A) or skewed (e.g., C-reactive protein) distribution, the information obtained by two statistical methods is different.The proposed statistical approach may be more appropriate in assessing difference between serial measurements when individual data are not normally distributed.
Urinary miR-183 and miR-205 do not surpass PCA3 in urine as predictive markers for prostate biopsy outcome despite their highly dysregulated expression in prostate cancer tissue
Authors: Stephan Carsten , Jung Monika , Rabenhorst Silke , Kilic Ergin , Jung Klaus 
Published: January 2015

AbstractMicroRNAs (miRNAs) have shown to be promising novel biomarkers in various cancers. We aimed to translate the results of an own previous tissue-based miRNA profile of prostate carcinoma (PCa) with upregulated miR-183 and downregulated miR-205 into a urine-based testing procedure for diagnosis of PCa.Urine sediments were prepared from urine samples collected after a standardized digital-rectal examination (DRE) of patients undergoing prostate biopsy with PSA (prostate-specific antigen) values <20 μg/L in consecutive order. According to the sample-size calculation (α=0.05, power=0.95), 38 patients each with PCa and without PCa were randomly enrolled in this study. PCA3 (prostate cancer associated 3) in urine as Food and Drug Administration-approved assay was determined as reference standard for comparison. The miRNAs were measured by RT-qPCR using TaqMan assays and normalized using different approaches.Both miRNAs were correlated to the mRNA PSA concentrations in the sediments indicating a relationship to the released prostate cells after DRE. However, they had no discriminating capacity between patients with and without PCa. In contrast, PCA3 clearly differentiated between these two patients groups. There was also no significant correlation between miRNAs and standard clinicopathologic variables like Gleason score and serum PSA.The data of our study show that miR-183 and miR-205 failed to detect early and aggressive PCa despite their highly dysregulated expression in cancer tissue. Our results and the critical evaluation of the few data of other studies raise serious doubts concerning the capability of urinary miRNAs to replace or improve PCA3 as predictive marker for prostate biopsy outcome.