bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Peraturan Bupati Karanganyar Nomor 59 Tahun 2021 Tentang Tata Cara Penegakan Disiplin Aparatur Sipil Negara di Lingkungan Pemerintah Kabupaten Karanganyar di Dinas Kesehatan Kabupaten Karanganyar
Authors: Pranata Bagus Indra , Agustiwi Asri 
Published: August 2024

Abstract
The purpose of this study is to determine the implementation of Karanganyar Regent Regulation Number 59 of 2021 concerning Procedures for Enforcement of State Civil Apparatus Discipline within the Karanganyar Regency Government at the Karanganyar Regency Health Office The type of research used in this thesis is sociological juridical research, which focuses on behavior that develops in society, or the operation of law in society. The data used used primary data in the form of interviews and secondary data consisting of primary, secondary and tertiary legal materials. Data collection using interviews, observation and literature study. The results showed that: Disciplinary enforcement against the State Civil Apparatus within the Karanganyar Regency government, especially the Karangnyar Regency Health Office, is in accordance with Karanganyar Regent Regulation Number 59 of 2021 concerning Procedures for Enforcement of State Civil Apparatus Discipline within the Karanganyar Regency Government. The Head of the Karanganyar Regency Health Office conducts an examination of the State Civil Apparatus suspected of committing an offense before being sentenced to disciplinary punishment. The examination is carried out in private through direct or virtual face-to-face and is outlined in the examination news.
Keywords: Discipline Enforcement, State Civil Apparatus, Health Office

Abstrak
Tujuan penelitian ini adalah untuk mengatahui implementasi Peraturan Bupati Karanganyar Nomor 59 Tahun 2021 Tentang Tata Cara Penegakan Disiplin Aparatur Sipil Negara di lingkungan Pemerintah Kabupaten Karanganyar di Dinas Kesehatan Kabupaten Karanganyar Jenis penelitian yang digunakan dalam skripsi ini adalah penelitian yuridis sosiologis, yang berfokus pada perilaku (behavior) yang berkembang dalam masyarakat, atau bekerjanya hukum dalam masyarakat. Data yang digunakan menggunakan data primer yang berupa wawancara dan data sekunder yang terdiri dari bahan hukum primer, sekunder dan tersier. Pengumpulan data menggunakan wawancara, observasi dan studi kepustakaan. Hasil penelitian menunjukkan bahwa: Penegakan disiplin terhadap Aparatur Sipil Negara dilingkungan pemerintahan Kabupaten Karanganyar, khususnya Dinas Kesehatan Kabupaten Karangnyar telah sesuai dengan Peraturan Bupati Karanganyar Nomor 59 Tahun 2021 Tentang Tata Cara Penegakan Disiplin Aparatur Sipil Negara di lingkungan Pemerintah Kabupaten Karanganyar. Kepala Dinas Kesehatan Kabupaten Karanganyar melakukan pemeriksaan kepada Aparatur Sipil Negara yang diduga melakukan pelanggaran sebelum dijatuhi hukuman disiplin. Pemeriksaan dilakukan secara tertutup melalui tatap muka langsung maupun virtual dan dituangkan dalam berita pemeriksaan.
Kata Kunci: Penegakan Disiplin, Aparatur Sipil Negara, Dinas Kesehatan
ANALISIS STRATEGI PEMASARAN ONLINE DAN OFFLINE PADA TOKO KERAJINAN LABANA ARTSHOP DITINJAU DARI PERSPEKTIF SYARIAH
Authors: Rokhilawati Yeni , Sholihah Fitriyatus 
Published: August 2024

Strategi pemasaran adalah strategi yang digunakan oleh suatu perusahaan dalam memperkenalkan barang dagangannya agar bisa laku diapasaran. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan deskriptif kualitatif, pengumpulan data, menggunakan beberapa metode yaitu obsevasi, wawancara dan dokumentasi. Sedangkan teknis analisis data menggunkan analisis data kualitatif (reduksi data, penyajian data dan penarikan kesimpulan). Sedangan pengecekan keabsahan data digunakan triangulasi sumber dan triangulasi teknik.Hasil penelitian yaitu Strategi pemasaran Online dan offline di Toko Kerajinan Labana Artshop menggunakan unsur 9p yang meliputi: Product, Price, Place, Promotio, People, Process, Physical Evidence, Promise, Patience.
Evaluating the Cognitive Impact of Anxiolytics on Elderly Patients: A prospective observational study.
Authors: Hasib Shamshad  , Sadaf Shamshad  
Published: August 2024

Background: The cognitive effects of anxiolytics in older adults are an important domain to research given the high rates of anxiety disorders and these medications commonly prescribed. Benzodiazepines, and some of the newer non-benzo" sedative anxiolytic agents have been associated with cognitive effects as a potential side effect. This study is going to be conducted in Lady Reading Hospital (LRH) Peshawar; thus the data will reflect upon population served by this particular hospital.
Objectives: To assess the cognitive impact of anxiolytic medication in geriatric patients, specifically on short-term memory (STM), attention and executive functions.
Design: A observational study.
Place and Duration of Study: Department of Pharmacy, Lady Reading Hospital-Peshawar starting from January 05th 2021 to July 05th ,2022.
Methods: This was an observational study conducted on 150 elderly patients at Lady Reading Hospital through non probability sampling, comparing cognitive domain of functioning between 75 users and rest controls. Cognitive function was evaluated by Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment before and after the medication.
Results - This section will describe the cognitive score changes in relation to anxiolytic use. One-way ANOVA will be utilized to examine the differences in cognitive outcomes according drug type, dosage and duration of use.
Conclusions: The use of anxiolytics in elderly patients is associated with deterioration cognitive function, which was confirmed by a decrease MMSE and MoCA scores during the course of treatment. The potential cognitive side effects when prescribing anxiolytics to the elderly requires a nuanced approach by healthcare providers.
Keywords: Anxiolytics; older adult patients; cognitive performance, MMSE/MoCA.
The Effect of Supportive Group Therapy on Post-Rehabilitation Drug User Resilience
Authors: Karnita Adinda Dwi , Fitria Intan Lailatul , Saputri Ulfah Murni , Mulyati Wiwin 
Published: August 2024

Personal Protective Equipment (PPE) is a toold designed as a barrier against the penetration of substances, solid particles, liquid or air to protect the wearer from injury, spread of infection or disease. The guard officers of the hospital must in the use of PPE for prevention and control of COVID-19. The purpose of the research is the factors that influence the behavior of the use of PPE of officers in the COVID-19 pandemic. This research uses correlative analysis design with cross sectional approach. Place and date of research in ER, outpatient, Radiology, Laboratory of Hospital in Blitar on November 30 – December 11, 2020. Population for research is hospital front guard officers in total sampling 47 respondent,of 8 general practitioners,5 specialists, 20 nurses, 2 radiographers, 4 analysts and 12 auxiliary officers. The research instrument uses observation sheets to the behavior of officers PPE usage and availability, COVID-19 knowledge questionnaires and hospital policy knowledge related to PPE. Resulth this research analysis using the Person product moment correlation test showed factors related to the behavior of PPE use is the knowledge of officers about COVID-19, hospital policies related to PPE and availability of PPE officers with a signification value P = 0.000. While unrelated factors are age and working life with signification values P = 0.208 and P = 0.387. Supervise the provision and use of PPE as needed so socialization to officers is important for prevention and control of COVID-19.
Muutuvad arusaamad lastest ja laste uuenduslik energia
Authors:   University of Tartu, Estonia, Kutsar Dagmar 
Published: August 2024

Understanding the child and childhood depends on the content attached to these concepts. Different images have prevailed in different times and they reflect in modern understandings of children. Drawing on Philippe Ariès’ seminal work, Centuries of Childhood, the paper offers a glimpse of images of children through time. History has portrayed the vulnerable, fragile child who needs protection and the immature child who needs to be educated and disciplined. Both images are represented in adults’ and children’s perceptions of today’s children. These perceptions in turn influence the way adults treat children. For example, a parent who sees the child as vulnerable and fragile may be overprotective and limit the child’s autonomous behaviour; another parent may not be able to negotiate with the child and may be easily punitive in situations where the child makes mistakes. According to children, they do not misbehave deliberately, but because they are immature and lack knowledge and experience. Understandably, they also agree with the image of a vulnerable child – in some situations they need to feel safe and protected. With the adoption of the Convention on the Rights of the Child by the UN General Assembly in 1989 and its ratification by state governments, the image of the socially competent child began to develop vigorously. The current article focuses on the competent image of the child, according to which a child is an active social agent and socially competent according to age to evaluate his or her lived life. The paper recalls keynotes of Ivar Frønes and Asher Ben-Arieh at international children’s well-being conference which was held in Tartu in 2019. According to them, while an adult thinks about life lived today, and thinking about tomorrow is the quest to “think out of the box”, a child has to live life forward each day, i.e., find solutions here and now, harnessing their innovative energy; for example, when confronted with new situations that require new solutions, or when interpreting and reproducing knowledge individually and collectively, shaping the world in which they live and, last but not least, bringing about change around them, e.g., contributing to the parent’s growth into parenthood. The challenge of modern childhood is to understand social processes in a forward-looking way, focusing not on future adulthood but on the here-and-now of childhood. Children use their innovative energy in everyday interactions and play, which is an important part of their lives. In a broad sense, play is action, it is practice of living, including the development of new skills and self-socialisation. There is plenty of innovative energy in children in their free play. In conclusion, it has to be said that, as society develops more rapidly, innovative energy and thinking are increasingly becoming a challenge for adults too. The article is based on the introductory presentation of the winter conference of folklorists, “Playing and Playfulness in Folklore”, held in Kuremaa Castle on 2–3 March 2023.
Research progress on the effects of postharvest storage methods on melon quality
Authors: Wang Haofei , Cui Jiayi , Bao Rui , Zhang Hui , Zhao Zi , Chen Xuanye , Wu Zhangfei , Wang Chaonan 
Published: August 2024

Background
As an important global agricultural cash crop, melon has a long history of cultivation and a wide planting area. The physiological metabolism of melon after harvest is relatively strong; if not properly stored, melon is easily invaded by external pathogens during transportation, resulting in economic losses and greatly limiting its production, development and market supply. Therefore, the storage and freshness of melon are the main challenges in realizing the annual supply of melon, so postharvest storage has received increasing amounts of attention from researchers.

Methods
This study used academic, PubMed, and Web of Science resources to retrieve keywords related to postharvest storage and melon quality; read, refined, classified, and sorted the retrieved literature; sorted and summarized the relevant research results; and finally completed this article.

Results
This article reviews the mechanism and effects of physical, chemical and biological preservation techniques on the sensory quality, compound contents and respiratory physiological activities of different varieties of melon fruits. When maintaining normal metabolism and not producing physiological disorders, melon inhibits cell wall metabolism, reactive oxygen species metabolism and the ethylene biosynthesis pathway, etc., to the greatest extent during postharvest storage, thereby reducing the material consumption of fruits, delaying the ripening and senescence process, and prolonging the postharvest life and shelf life.

Conclusion
The literature provides a theoretical basis for postharvest preservation technology in the melon industry in the future and provides corresponding guidance for the development of the melon industry.
Effect of Different Levels of Farmyard Manure (FYM) Integrated with Organic Modules on Yield, Quality and Pest Incidence of Okra (Abelmoschus esculentus L. Moench)
Authors: Teja Rachamalla Ravi , Kumar A. Kiran , Kumar T. Suresh , Kumar B. Naveen , Sathish G. 
Published: August 2024

The study was conducted during late Kharif season during 2021-22 and 2022-23 at administrative office (PGIHS), Sri Konda Laxman Telangana State Horticultural University, Mulugu, Telangana, India. The experiment was laid out in contrast factorial randomized block design (CFRBD) with two factors i.e., factor-1 consists of three levels of FYM and factor-2 consists of three organic modules and separate control (100% RDF) plot was grown and replicated thrice. The pooled results indicated that, control treatment (100 % RDF-100:50:50 kg NPK/ha) reported highest number of fruits per plant (19.05), highest fruit weight (14.72 g), maximum fruit yield per plant (0.28 kg), maximum fruit yield per hectare (9.52 t/ha) over the other treatments. L1M1 (FYM equivalent to 100 % RDN + organic module-1) registered minimum crude fibre content (7.10%), and maximum chlorophyll content in fresh fruit (1.19 mg/100g). While, minimum mean percent of fruit infestation (6.28%) was reported with control (100% RDF-100:50:50kg NPK/ha + emamectin benzoate 5%SG @ 70 g/200 lit) and lowest mean population of jassid per leaf (1.08/leaf), was recorded with control (100 % RDF-100:50:50 kg NPK/ha + imidacloprid 17.8 SL @ 100 ml/acre).
DNAInterstrand Crosslink Repair
Authors: Siede Wolfram 
Published: August 2014

AbstractCrosslinking agents such as psoralens, nitrogen mustards or cisplatin are bifunctionally acting chemicals that generate a fraction of their adducts as covalent linkages between complementary deoxyribonucleic acid strands. Since many of these agents are of importance in genetic toxicology and cancer therapy, repair of interstrand crosslinks has been studied extensively in bacteria and in lower and higher eukaryotes. The main repair pathway inEscherichia coliinvolves the sequential action of nucleotide excision repair (NER) and recombinational repair. In eukaryotes, several repair pathways play important roles not only in repair including NER, translesion synthesis and recombination, but also mismatch repair. Relative contributions of the various pathways depend on cell cycle position and agent used. Eukaryotic proteins that specifically enhance resistance to crosslinking agents have been identified (FANC family of proteins, SNM1).Key Concepts:Chemicals with two or more correctly spaced reactive groups can covalently link opposing DNA strands.Several repair or tolerance pathways such as nucleotide excision repair, recombination and translesion synthesis can work together to overcome such complex damage.Cell cycle stage may determine the choice of repair pathway combinations.A heritable human syndrome with multiple diverse phenotypes (Fanconi anaemia) has been associated with defects in crosslink repair.By integratingin vitrostudies and analysis of Fanconi proteins, current models of replication‐dependent crosslink repair assume the creation of double strand breaks at stalled replication forks that are repaired by homologous recombination.
Plant Secondary Metabolism
Authors: Sato Fumihiko 
Published: August 2014

Abstract

Plants synthesise an extraordinary array of natural products that usually do not play a role in their growth and development, and thus are traditionally referred to as secondary metabolites. However, recent advances in plant sciences have revealed that these compounds not only function in response to environmental stimuli, but also play more basic roles in plant growth. Secondary metabolites have several important roles in plants: they protect against herbivores and microbial infection and act as signals for symbiotic bacteria and mycorrhiza, attractants for pollinators and seed‐dispersing animals, allelopathic agents in natural habitats, physical and chemical barriers to abiotic stressors such as UV and evaporation and endogenous regulators of plant growth hormones. Many secondary metabolites are also useful for mankind as dyes, essential oils, flavouring agents, pesticides, pharmaceuticals, tanning agents and so on. Rapid advances in the metabolic engineering and synthetic biology of secondary metabolites have revealed novel physiological roles of these secondary metabolites in plants.

Key Concepts:

Plants synthesise a vast array of natural products (secondary metabolites) in response to environmental stimuli.

Secondary metabolites have several important roles: they protect against herbivores and microbial infection and act as attractants for pollinators and seed‐dispersing animals, allelopathic agents in natural environments and endogeneous regulators of plant growth.

Secondary metabolites are synthesised from primary metabolites such as acetate, pyruvate, and amino acids, and are mainly classified into three major groups; the terpenoids, the phenolics (mainly phenylpropanoids) and alkaloids.
Chance and Necessity: Emerging Introns in Intronless Retrogenes
Authors: Tan Shengjun , Zhu Zhenglin , Zhu Tao , Te Rigen , Zhang Yong E 
Published: August 2014

Abstract

Retrogenes are duplicated genes generated via retroposition, which were conventionally believed to contain no introns. However, emerging data showed that a significant number of retrogenes do have introns. Thus, these genes represent an attractive system to study how new genes evolve exon–intron structure. Comparison between parental genes and retrogenes revealed that retrogenes mainly evolve chimeric structures by fusing with local host genes or recruiting pre‐existing intergenic sequences. Additionally, retrogenes could gain introns by inheriting introns of parental genes or by transforming parental exonic sequences. The functional necessity on intron gain in retrogenes remains largely elusive although limited data suggest that newborn introns play regulatory roles, enable exon shuffling and alternative splicing. Accumulation of population genomic data may help to understand which evolutionary force shapes the fixation of introns in both retrogenes and
de novo
originated genes given the same intron birth process acts on both type of new genes.

Key Concepts:

Retrogenes evolve new exon–intron structures mainly by chimerism in both plants and animals.

Retrogenes could directly inherit introns from their parental genes.

Retrogenes could gain introns by intronization mechanism.

Intron insertion is rare in retrogenes.

Introns in retrogenes may have three functions: exon shuffling, alternative splicing and expression regulation.
Impact of Missense Variants on Protein–Protein Interactions
Authors: Yates Christopher M , Sternberg Michael JE 
Published: August 2014

AbstractSingle nucleotide polymorphisms (SNPs) are the most common form of human genetic variation and can affect the protein sequence. These missense variants may affect protein stability, function or interactions with other proteins, potentially leading to disease. Protein–protein interactions (PPIs) can be strengthened or weakened by missense variants, which can cause loss of salt bridges, steric clashes or changes to post‐translational modifications, amongst other effects. Changes to PPIs can lead to rewiring of the PPI network and this can be responsible for altered phenotype. Variants at different interfaces can, in some cases, lead to different phenotypes by affecting different pathways and complexes. Understanding the effects of missense variants on PPIs and the interactome is helpful in determining how these variants can lead to disease, as shown by the improved predictive performance of our variant phenotype predictor SuSPect, which includes network features.Key Concepts:Missense variants can impact upon protein–protein interactions in numerous ways.Impaired or enhanced interactions can both lead to disease.Interactions can be affected by steric clashes, loss of salt bridges, changes to intrinsic disorder and several other mechanisms.Variants in different parts of proteins can affect different interactions, potentially leading to different diseases.Variants on corresponding interfaces in different proteins can lead to the same (or similar) disease.Investigating the effects of variants in the context of interaction networks rather than in isolation can give important extra information.
Exploring the in situ Utilization of Cyclic Imine Intermediates Generated by Isocyanoacetate Cycloaddition: Convergent Assembly of cis‐3a,8a‐Hexahydropyrrolo[2,3‐b]indole Scaffolds
Authors: Huang Lin , Cheng Hengguang , Zhang Runmei , Wang Min , Xie Chunsong 
Published: August 2014

AbstractUnder copper(I) or silver(I)/base cocatalysis conditions, transient 2H‐pyrroline intermediates generated by the cycloaddition of isocyanoacetates and olefins can be in situ subjected to further transformations. A strategically novel, convergent, mild, efficient, general and atom‐economic access to cis‐3a,8a‐hexahydropyrrolo[2,3‐b]indoles, which are core scaffolds in many biologically important natural products, has been developed based on this concept.magnified image
High‐level conversion of L‐lysine into 5‐aminovalerate that can be used for nylon 6,5 synthesis
Authors: Park Si Jae , Oh Young Hoon , Noh Won , Kim Hye Young , Shin Jae Ho , Lee Eun Gyo , Lee Seungwoon , David Yokimiko , Baylon Mary Grace , Song Bong Keun , Jegal Jonggeon , Lee Sang Yup , Lee Seung Hwan 
Published: August 2014

AbstractL‐Lysine is a potential feedstock for the production of bio‐based precursors for engineering plastics. In this study, we developed a microbial process for high‐level conversion of L‐lysine into 5‐aminovalerate (5AVA) that can be used as a monomer in nylon 6,5 synthesis. Recombinant Escherichia coli WL3110 strain expressing Pseudomonas putida delta‐aminovaleramidase (DavA) and lysine 2‐monooxygenase (DavB) was grown to high density in fed‐batch culture and used as a whole cell catalyst. High‐density E. coli WL3110 expressing DavAB, grown to an optical density at 600 nm (OD600) of 30, yielded 36.51 g/L 5AVA from 60 g/L L‐lysine in 24 h. Doubling the cell density of E. coli WL3110 improved the conversion yield to 47.96 g/L 5AVA from 60 g/L of L‐lysine in 24 h. 5AVA production was further improved by doubling the L‐lysine concentration from 60 to 120 g/L. The highest 5AVA titer (90.59 g/L; molar yield 0.942) was obtained from 120 g/L L‐lysine by E. coli WL3110 cells grown to OD600 of 60. Finally, nylon 6,5 was synthesized by bulk polymerization of ϵ‐caprolactam and δ‐valerolactam prepared from microbially synthesized 5AVA. The hybrid system demonstrated here has promising possibilities for application in the development of industrial bio‐nylon production processes.