bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Review: Practices and Programs in Inflammatory Bowel Disease Transition Care
Authors: Chan Patrick , McNamara Jack , Vernon-Roberts Angharad , Giles Edward M , Havrlant Rachael , Christensen Britt , Thomas Amanda , Williams Astrid-Jane 
Published: August 2024

Abstract

Background
Adolescents with inflammatory bowel disease (IBD) transitioning to adult care is often deemed a challenging period for patients, their carers, and practitioners. The use of structured transition programs is increasingly incorporated into standards of care, yet the optimal format remains unknown. The aim of this study is to carry out a systematic review of structured transition programs and their components to assess the impact on disease-specific and transition-related outcomes.

Methods
A systematic review (PROSPERO ID: CRD42023380846) was performed across 4 databases (PubMed, CINAHL, CENTRAL, and EMBASE) and relevant publications up to March 2023 were reviewed. Studies evaluating either a structured transition program or targeted intervention which also measured a transition- and/or disease-related outcomes were included for evaluation in accordance with the PRISMA statement.

Results
Three thousand four hundred and thirty-two articles were identified and 29 included in the final review. A structured transition program was reported in 21 studies and 8 investigated discrete transition-related interventions. The key transition-related outcomes included knowledge, self-efficacy, adherence, clinic attendance, and transition readiness which overall improved with the use of structured transition programs. Similarly, interventions consistently improved relapse/admission rates and corticosteroid use across most studies, although the benefit in hospitalization and surgical rates was less evident. Methodological limitations alongside heterogeneity in study design and outcome measures impacted on the quality of the evidence as assessed by the GRADE rating.

Conclusions
Transition- and medical-related outcomes for adolescents with IBD have been shown to benefit from structured transition programs but practices vary greatly between centers. There is no current standardized transition model for patients with IBD prompting further research to guide future development of guidelines and models of care.
The Potential of Molecular Remission: Tissue Neutrophil Elastase Is Better Than Histological Activity for Predicting Long-Term Relapse in Patients With Ulcerative Colitis in Endoscopic Remission
Authors: Jun Yu Kyung , Oh Hyeon Jeong , Lee Ji Ae , Choi Yonghoon , Shin Cheol Min , Park Young Soo , Kim Nayoung , Lee Dong Ho , Yoon Hyuk 
Published: August 2024

Abstract

Background
Growing interest exists in deep remission, beyond clinical and endoscopic remission, to enhance long-term prognosis in patients with ulcerative colitis (UC). Our study aimed to evaluate the risk of relapse according to tissue expression levels of calprotectin and neutrophil elastase (NE) in patients with quiescent UC.

Methods
Rectal biopsies were performed on 218 patients with UC in clinical and endoscopic remission. Histological activity was prospectively scored using the Robarts Histological Index. Tissue calprotectin and NE levels were evaluated using immunohistochemistry. Optimal tissue calprotectin and NE cutoffs for relapse were determined using log-rank analysis. Cox proportional hazard analyses evaluated relapse risk factors.

Results
Tissue calprotectin and NE levels were significantly higher in patients with histological activity than in those in histological remission (P &lt; .001). The optimal cutoffs of tissue calprotectin and NE for relapse were 10.61 and 22.08 per mm2, respectively. The 3-year clinical relapse risk was significantly lower in the low-tissue NE group than in the high-tissue NE group (P = .009); however, it did not differ between the low- and high-tissue calprotectin group (P = .094). In multivariate analyses, a low level of tissue NE expression was independently associated with a lower risk of 3-year clinical relapse (adjusted hazard ratio = 0.453, 95% confidence interval = 0.225–0.911, P = .026), unlike histological index and tissue calprotectin.

Conclusions
In patients with UC who have achieved clinical and endoscopic remission, tissue expression of NE is a better predictor of long-term relapse than histological activity.
Communicating Information Regarding IBD Remission to Patients: Evidence From a Survey of Adult Patients in the United States
Authors: Wood Dallas W , Treiman Katherine , Rivell Aileen , van Deen Welmoed K , Heyison Hilary , Mattar Mark C , Power Sydney , Strauss Alyssa , Syal Gaurav , Zullow Samantha , Ehrlich Orna G 
Published: August 2024

Abstract

Background
Previous research suggests patients living with inflammatory bowel disease (IBD) understand IBD remission differently than healthcare professionals, which could influence patient expectations and clinical outcomes. We investigated 3 questions to better understand this: (1) How do patients currently understand remission; (2) Do patients currently face any barriers to communicating with their healthcare professional about remission; and (3) Can existing educational material be improved to help patients feel more prepared to discuss remission and treatment goals with their healthcare professional?

Methods
We sent a web-based survey to adult patients with IBD in the United States. This survey included an educational experiment where patients were randomly assigned to 1 of 3 improved versions of existing educational material.

Results
In total, 1495 patients with IBD completed the survey. The majority of patients (67%) agreed that remission is possible in IBD, but there was significant diversity in how they defined it with the most common being “my symptoms are reduced” (22%) and “I am no longer experiencing any symptoms” (14%). Patients reported being able to communicate openly with their healthcare professionals. Exposure to improved educational material did not have a statistically significant effect on patients’ feelings of preparedness for discussing different aspects of their care with their healthcare professionals.

Conclusions
Our study confirms that patients tend to define remission in terms of resolving symptoms. We found little evidence of barriers preventing patients from discussing remission with their healthcare professionals. This suggests that educational material could be used to resolve this discrepancy in understanding.
The Common Basis Complex and the Partial Decomposition Poset
Authors: Brück Benjamin , Piterman Kevin I , Welker Volkmar 
Published: August 2024

Abstract
For a finite-dimensional vector space $V$, the common basis complex of $V$ is the simplicial complex whose vertices are the proper non-zero subspaces of $V$, and $\sigma $ is a simplex if and only if there exists a basis $B$ of $V$ that contains a basis of $S$ for all $S\in \sigma $. This complex was introduced by Rognes in 1992 in connection with stable buildings. In this article, we prove that the common basis complex is homotopy equivalent to the proper part of the poset of partial direct sum decompositions of $V$. Moreover, we establish this result in a more general combinatorial context, including the case of free groups, matroids, vector spaces with non-degenerate sesquilinear forms, and free modules over commutative Hermite rings, such as local rings or Dedekind domains.
Genetic characterization of vancomycin-resistant Enterococcus faecium isolates from neutropenic patients in Tunisia: spread of the pandemic CC17 clone associated with high genetic diversity in Tn1546-like structures
Authors: Raddaoui Anis , Chebbi Yosra , Frigui Siwar , Latorre Javier , Ammeri Rim Werhani , Abdejlil Nour Ben , Torres Carmen , Abbassi Mohamed Salah , Achour Wafa 
Published: August 2024

Abstract

Aims
In Tunisia, limited research has focused on characterizing clinical vancomycin-resistant Enterococcus faecium (VREfm). This study aimed to bridge this knowledge gap by molecular characterization of antimicrobial resistance, determining the genetic elements mediating vancomycin-resistance, and whole-genome sequencing of one representative VREfm isolate

Methods and results
Over 6 years (2011–2016), a total of eighty VREfm isolates responsible for infection or colonization were identified from hospitalized patients, with the incidence rate increasing from 2% in 2011 to 27% in 2016. All of these strains harbored the vanA gene. The screening for antimicrobial resistance genes revealed the predominance of ermB, tetM, and aac(6′)-Ie-aph(2′’)-Ia genes and 81.2% of strains harbored the Tn1545. Pulsed-field gel electrophoresis identified seven clusters, with two major clusters (belonging to ST117 and ST80) persisting throughout the study period. Seven Tn1546 types were detected, with type VI (truncated transposon) being the most prevalent (57.5%). Whole-genome sequencing revealed a 3 028 373 bp chromosome and five plasmids. Mobile genetic elements and a type I CRISPR-cas locus were identified. Notably, the vanA gene was carried by the classic Tn1546 transposon with ISL3 insertion on a rep17pRUM plasmid.

Conclusion
A concerning trend in the prevalence of VREfm essentially attributed to CC17 persistence and to horizontal transfer of multiple genetic variants of truncated vanA-Tn1546.
Brand Teasing: How Brands Build Strong Relationships by Making Fun of Their Consumers
Authors: Oba Demi , Howe Holly S , Fitzsimons Gavan J 
Published: August 2024

Abstract
Popular brands like Wendy’s, Postmates, and RyanAir have gained notoriety by making fun of their consumers, but is this an effective strategy to build strong consumer relationships? Across 11 (seven pre-registered) studies, using lab data, field data, and a variety of analytical approaches, the current research demonstrates that teasing communication increases consumer engagement with and connection to the brand compared to merely funny or neutral communication. These effects occur because consumers anthropomorphize brands more when they use teasing communication. This leads to greater engagement with brand messages and greater self-brand connection (SBC). We also leverage the interpersonal teasing literature to distinguish between prosocial and antisocial teases and highlight an important boundary condition. Specifically, we demonstrate that while prosocial teasing evokes a positive human schema, antisocial teasing, although still anthropomorphic, activates a negative human schema, which reduces connection to the brand. As a result, antisocial teases lose their relational advantage over purely funny communication. This work contributes to the streams of research on brand humor, anthropomorphism, and consumer–brand relationships. It also provides actionable implications by demonstrating a novel antecedent to consumer–brand connection and the boundaries within which these positive effects are expected to occur.
Positive Contrast Scope Insensitivity
Authors: Voichek Guy , Novemsky Nathan 
Published: August 2024

Abstract
When consumers compare a worse product to a better product, negative contrast can make the worse product less attractive, and positive contrast can make the better product more attractive. We show that positive contrast is relatively scope insensitive: the size of the difference between products affects negative contrast but not positive contrast. Even when the difference between products is small enough to make negative contrast negligible, positive contrast remains strong. This means that when consumers compare a product to a slightly worse product, contrast makes the better product more attractive without making the worse product any less attractive. The asymmetry occurs because consumers are less likely to consider the size of the difference between products when evaluating the better product than when evaluating the worse product, such that nudging consumers to consider the size of the difference eliminates the asymmetry.
Victorian Institute of Sport Assessment questionnaire specifically tailored for greater trochanteric pain syndrome for the Dutch population
Authors: Van Quickenborne Damien , Van Der Straeten Catherine , Burssens Arne , Audenaert Emmanuel 
Published: August 2024

Abstract
Greater trochanteric pain syndrome (GTPS) is a highly prevalent condition characterized by lateral hip and thigh pain. The Victorian Institute of Sport Assessment (VISA) questionnaire specifically tailored for GTPS (VISA-G) questionnaire was developed for the purpose of assessing and quantifying the severity of symptoms related to gluteal tendinopathy or GTPS. It is commonly used in research and clinical settings to evaluate the impact of GTPS on patient function and quality of life. The VISA-G questionnaire was developed for English-speaking populations. Before this questionnaire can be used in non-English-speaking populations, it has to be translated and validated for a particular population. The current study aimed to translate and validate the VISA-G questionnaire for a Dutch-speaking context (VISA-G-Dutch). In this study, we conducted a comprehensive process involving forward and back translation, along with a thorough comparison with other established hip-related questionnaires. The COSMIN checklist was used to ensure uniformity in the validation study. A sample of 100 participants, 50 symptomatic and 50 asymptomatic, completed the VISA-G-Dutch, Harris Hip Score, Hip Disability and Osteoarthritis Outcome Score, Oxford Hip Score, and Nonarthritic Hip Score questionnaires. Internal consistency and test–retest reliability were measured. Construct validity was assessed through positive correlations between the VISA-G-Dutch and gold standard questionnaires. Strong internal consistency and test–retest reliability correlations were found in both the asymptomatic and symptomatic groups. The test–retest reliability also demonstrated strong positive correlations for the symptomatic group. The standard error of measurement was ∼2.3 for the symptomatic group. These results prove that the VISA-G-Dutch is a reliable and valid tool for assessing GTPS and gluteal tendinopathy in Dutch-speaking individuals, providing clinicians with a valuable assessment tool.
Dual nematode infection in Brassica nigra affects shoot metabolome and aphid survival in distinct contrast to single-species infection
Authors: Pajar Jessil Ann , Otto Pius , Leonar April Lyn , Döll Stefanie , van Dam Nicole M 
Published: August 2024

Abstract
Previous studies showed that aphid performance was compromised on Brassica nigra infected by root-lesion nematodes (Pratylenchus penetrans, Pp), but less, or positively influenced by root-knot nematode (Meloidogyne spp.) infection. These experiments were on single-species nematode infections, but roots can be infected naturally with several nematode species simultaneously. We performed greenhouse assays to assess the effects of single [Meloidogyne incognita (Mi) or Pp] and concurrent (MP) nematode infections on aphid performance. Using targeted and untargeted profiling of leaf and phloem metabolomes, we examined how single and concurrent nematode infections affect shoot metabolomes, and elucidated the possible consequences for aphid performance. We found that the metabolic response to double-infection is different from that to single-species infections. Moreover, Mi and Pp infections triggered discrete changes in B. nigra leaf and phloem metabolic profiles. Both Pp and MP infections reduced aphid survival, suggesting that the biological effect could primarily be dominated by Pp-induced changes. This concurred with increased indole glucosinolates and hydroxycinnamic acid levels in the leaves, in particular the putative involvement of salicylic acid-2-O-β-d-glucoside. This study provides evidence that concurrent infection by different nematode species, as is common in natural environments, is associated with distinct changes in aboveground plant metabolomes, which are linked to differences in the survival of an aboveground herbivore.
Compost tea enhances volatile content in tomato fruits via SlERF.E4-activated SlLOX expression
Authors: Li Wenxin , Quan Jiajia , Wen Yongshuai , Gao Meng , Li Jianming 
Published: August 2024

Abstract
Aroma volatiles, essential for tomato fruit flavor, have been reported to accumulate more abundantly in fruits from plants cultivated with compost tea. However, the underlying molecular mechanisms by which compost tea regulates aroma volatile synthesis in tomato (Solanum lycopersicum L.) fruit remains elusive. Here, we found that compost tea treatment significantly increased the content of volatiles derived from fatty acids in tomato fruit. Transcriptional analysis revealed that compost tea treatment up-regulated the expression of linolenic acid metabolic pathway LOX genes (SlLOXD and SlLOXE). Furthermore, overexpression of SlLOXD and SlLOXE enhanced the volatiles in fruit, while compost tea treatment failed to increase volatiles content in loxd and loxe mutants. Interestingly, compost tea treatment increased the level of ACC, a precursor of ethylene. Treatment with an ethylene signaling inhibitor 1-methylcyclopropene (1-MCP) negated the aroma enhancement effect of compost tea on tomato fruits. SlERF.E4, a transcription factor responsive to ethylene signaling, was found to bind to the promoters of SlLOXD and SlLOXE. Overexpression of SlERF.E4 led to increased expression of SlLOXD and SlLOXE, as well as elevated fruit volatile content. Indeed, aroma enhancement in the SlERF.E4-overexpressed tomatoes was not affected by 1-MCP. These findings shed light on the molecular mechanisms underlying the improvement of flavor in organic fruits and provide valuable insights for the development of strategies in organic agriculture.
Correlation between sporogenesis and lipopeptide production in Paenibacillus elgii
Authors: da Costa Rosiane Andrade , Andrade Isadora Emanoela Pereira Costa , de Araújo Thiago Fellipe , Fulgêncio Débora Luiza Albano , Mendonça Marise Leite , Rocha Gabriel Iudy Yamaguchi , dos Santos Raiana Moreira , Barreto Cristine Chaves 
Published: August 2024

Abstract
Pelgipeptins, tridecaptins, and elgicins are among the antimicrobials produced by Paenibacillus elgii. Growth in complex media is commonly applied to obtain lipopeptides from culture’s supernatant, but it requires further purification. This study aimed to improve the yield of pelgipeptins and tridecaptins using chemically defined media. The kinetics of antimicrobial lipopeptide yield in chemically defined media were evaluated in P. elgii AC13. Pelgipeptins were detected in the supernatant and the culture pellet, but tridecaptins were mainly associated with cell debris or endospores. We investigated whether removing Ca2+ would impair P. elgii sporogenesis, consequently improving the yield of tridecaptin. The kinetics of both lipopeptides in the presence and absence of Ca2+ were quantitatively and qualitatively evaluated and further correlated with the cell cycle. The impairment of P. elgii AC13 sporogenesis had no effect on tridecaptin production, which remained undetected in the supernatant of the culture. On the other hand, the yield of pelgipeptin in a Ca2+-free medium increased. We showed for the first time that the removal of Ca2+ interrupted the sporogenesis in P. elgii and improved the yield of pelgipeptins. However, Ca2+ absence had no effect on tridecaptin yield, which is possibly degraded or associated with other cell debris components.
Cell surface protein–protein interaction profiling for biological network analysis and novel target discovery
Authors: Chen Jiaojiao , Fang Maoxin , Li Yuwei , Ding Haodong , Zhang Xinyu , Jiang Xiaoyi , Zhang Jinlan , Zhang Chengcheng , Lu Zhigang , Luo Min 
Published: August 2024

Abstract
The secretome is composed of cell surface membrane proteins and extracellular secreted proteins that are synthesized via secretory machinery, accounting for approximately one-third of human protein-encoding genes and playing central roles in cellular communication with the external environment. Secretome protein–protein interactions (SPPIs) mediate cell proliferation, apoptosis, and differentiation, as well as stimulus- or cell-specific responses that regulate a diverse range of biological processes. Aberrant SPPIs are associated with diseases including cancer, immune disorders, and illness caused by infectious pathogens. Identifying the receptor/ligand for a secretome protein or pathogen can be a challenging task, and many SPPIs remain obscure, with a large number of orphan receptors and ligands, as well as viruses with unknown host receptors, populating the SPPI network. In addition, proteins with known receptors/ligands may also interact with alternative uncharacterized partners and exert context-dependent effects. In the past few decades, multiple varied approaches have been developed to identify SPPIs, and these methods have broad applications in both basic and translational research. Here, we review and discuss the technologies for SPPI profiling and the application of these technologies in identifying novel targets for immunotherapy and anti-infectious agents.
Theoretical investigation of interstellar 3-pyrroline: formation and, rotational and vibrational spectroscopy
Authors: Pandey Anshika , Vats Akant , Srivastav Satyam , Pathak Amit , Singh K A P 
Published: August 2024

ABSTRACT
The recent detection of CN-functionalized aromatics partly addresses the long-standing mystery of the apparent absence of five- and six-membered rings in interstellar environments. Nitrogen (N)-heterocycles, which are crucial as the fundamental structures of nucleobases, have been a focus of these aromatic searches due to their biological significance. Although N-heterocycles have not been conclusively detected in astrophysical environments, their presence in chondrites and meteorites signifies their interstellar and circumstellar connection. Precise spectral data identify the unique signatures of molecules, confirming their presence in space. In this light, this work reports an extensive computational investigation on interstellar 3-pyrroline, a five-membered ring N-heterocycle. This includes an alternative formation route in cold interstellar environments and highly accurate rotational and vibrational spectroscopy. The results indicate that 3-pyrroline can form on dust grain surfaces from vinyl cyanide, as its formation from pyrrole through double hydrogenation may lead to the formation of pyrrole itself via an H2-abstraction process. 3-Pyrroline’s rotational transition at 52.3 GHz offers a potential tool for its detection in cold interstellar regions. Additionally, the strongest infrared (IR) features of 3-pyrroline at 16.09 and $\sim$3.50 $\mu$m are observable with JWST. The provided data are crucial for laboratory identification and future interstellar observations of 3-pyrroline at both radio and IR wavelengths.