bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review of outcomes used to evaluate enhanced recovery after surgery
Authors: Neville A , Lee L , Antonescu I , Mayo N E , Vassiliou M C , Fried G M , Feldman L S 
Published: January 2014

Abstract

Background
Enhanced recovery pathways (ERPs) aim to improve patient recovery. However, validated outcome measures to evaluate this complex process are lacking. The objective of this review was to identify how recovery is measured in ERP studies and to provide recommendations for the design of future studies.

Methods
A systematic search of MEDLINE, Embase and Cochrane databases was conducted. Prospective studies evaluating ERPs compared with traditional care in abdominal surgery published between 2000 and 2013 were included. All reported outcomes were classified into categories: biological and physiological variables, symptom status, functional status, general health perceptions and quality of life (QoL). The phase of recovery measured was defined as baseline, intermediate (in hospital) and late (following discharge).

Results
A total of 38 studies were included based on the systematic review criteria. Biological or physiological variables other than postoperative complications were reported in 30 studies, and included return of gastrointestinal function (25 studies), pulmonary function (5) and physical strength (3). Patient-reported symptoms, including pain (16 studies) and fatigue (9), were reported less commonly. Reporting of functional status outcomes, including mobilization (16 studies) and ability to perform activities of daily living (4), was similarly uncommon. Health aspects of QoL were reported in only seven studies. Length of follow-up was generally short, with 24 studies reporting outcomes within 30 days or less. All studies documented in-hospital outcomes (intermediate phase), but only 17 reported postdischarge outcomes (late phase) other than complications or readmission.

Conclusion
Patient-reported outcomes, particularly postdischarge functional status, were not commonly reported. Future studies of the effectiveness of ERPs should include validated, patient-reported outcomes to estimate better their impact on recovery, particularly after discharge from hospital.
Outcomes after laparoscopic conversion of failed adjustable gastric banding to sleeve gastrectomy or Roux-en-Y gastric bypass
Authors: Marin-Perez P , Betancourt A , Lamota M , Lo Menzo E , Szomstein S , Rosenthal R 
Published: January 2014

Abstract

Background
Laparoscopic adjustable gastric banding (LAGB) has a high incidence of long-term complications and failures. The best procedure to handle these failures and the optimal number of stages in such cases is still controversial. The aim of this retrospective study was to compare the results of conversions of LAGB to either laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Ygastric bypass (LRYGB) in failed LAGB using a single-stage approach.

Methods
All patients who underwent conversion from LAGB to either LRYGB or LSG between January 2005 and March 2012 were included in the study. Early and late complications were reviewed. The percentage excess weight loss (%EWL) between the two groups was compared at 3, 6, 12 and 24 months of follow-up.

Results
Fifty-nine patients, 11 men and 48 women, were included in the study. The most frequent indication was insufficient weight loss or weight regain (non-responders group), in 44 patients (75 per cent); 15 patients had a revision for complicated LAGB. The early complication rate in the non-responders group was 7 per cent (3 of 44 patients), compared with 13 per cent (2 of 15) in the complicated LAGB group. Mean(s.d.) %EWL in the non-responders group was 55(22) per cent in patients converted to LRYGB and 28(25) in those converted to LSG (P = 0·001).

Conclusion
LRYGB and LSG are both safe and feasible options for failed or complicated LAGB. In the non-responders group, %EWL was superior for conversion to LRYGB. The surgical morbidity rate was highest in patients having revision for band complications.
New applications of recurrent relations: precalculation of pKa values of substituted alkanecarboxylic acids
Authors: Zenkevich Igor G. 
Published: January 2014

The series of substituted alkanecarboxylic acids including insertion homologues of ω‐substituted acids X(CH2)nCO2H (n ≥ 1) and isomers that differ in the position of substituents X in the alkyl fragments, k‐X(CnH2n)CO2H (n = const ≥ 1, 1 ≤ k ≤ n + 1) is the sub‐group most poorly characterized by their acidity constants, pKa, comparing with the acids of the other sub‐groups. When the experimental data for such compounds are unavailable, the precalculated estimates should be taken into consideration.The pKa values for such acids can be calculated using the single first‐order recurrent relation, pKa(n + 1) = apKa(n) + b, using pKa values of other (usually the simpler and, consequently, better characterized) homologues and/or isomers of the same series. This algorithm results from the unique mathematical properties of recurrent relations in chemistry. Copyright © 2014 John Wiley & Sons, Ltd.
Combining Complementary Ligands into one Framework for the Construction of a Ferromagnetically Coupled [MnIII12] Wheel
Authors: Sanz Sergio , Frost Jamie M. , Rajeshkumar Thayalan , Dalgarno Scott J. , Rajaraman Gopalan , Wernsdorfer Wolfgang , Schnack Jürgen , Lusby Paul. J. , Brechin Euan K. 
Published: January 2014

AbstractPhenolic oxime and diethanolamine moieties have been combined into one organic framework, resulting in the formation of a novel ligand type that can be employed to construct a rare and unusual dodecametallic Mn wheel, within which nearest neighbours are coupled ferromagnetically.
Enantiomeric Separation and Simulation Studies of Pheniramine, Oxybutynin, Cetirizine, and Brinzolamide Chiral Drugs on Amylose‐Based Columns
Authors: Ali Imran , Al‐Othman Zeid A. , Al‐Warthan Abdulrahman , Alam Syed Dilshad , Farooqi Javed A. 
Published: January 2014

ABSTRACTSolid phase extraction (SPE)‐chiral separation of the important drugs pheniramine, oxybutynin, cetirizine, and brinzolamide was achieved on the C18 cartridge and AmyCoat (150 x 46 mm) and Chiralpak AD (25 cm x 0.46 cm id) chiral columns in human plasma. Pheniramine, oxybutynin, cetirizine, and brinzolamide were resolved using n‐hexane‐2‐PrOH‐DEA (85:15:0.1, v/v), n‐hexane‐2‐PrOH‐DEA (80:20:0.1, v/v), n‐hexane‐2‐PrOH‐DEA (70:30:0.2, v/v), and n‐hexane‐2‐propanol (90:10, v/v) as mobile phases. The separation was carried out at 25 ± 1 ºC temperature with detection at 225 nm for cetirizine and oxybutynin and 220 nm for pheniramine and brinzolamide. The flow rates of the mobile phases were 0.5 mLmin‐1. The retention factors of pheniramine, oxybutynin, cetirizine and brinzolamide were 3.25 and 4.34, 4.76 and 5.64, 6.10 and 6.60, and 1.64 and 2.01, respectively. The separation factors of these drugs were 1.33, 1.18, 1.09 and 1.20 while their resolutions factors were 1.09, 1.45, 1.63 and 1.25, and 1.15, respectively. The absolute configurations of the eluted enantiomers of the reported drugs were determined by simulation studies. It was observed that the order of enantiomers elution of the reported drugs was S‐pheniramine > R‐pheniramine; R‐oxybutynin > S‐oxybutynin; S‐cetirizine > R‐cetirizine; and S‐brinzolamide > R‐brinzolamide. The mechanism of separation was also determined at the supramolecular level by considering interactions and modeling results. The reported SPE‐chiral high‐performance liquid chromatography (HPLC) methods are suitable for the enantiomeric analyses of these drugs in any biological sample. In addition, simulation studies may be used to determine the absolute configuration of the first and second eluted enantiomers. Chirality 26:136–143, 2014. © 2014 Wiley Periodicals, Inc.
A time series and reduction‐based model for modeling and QoS prediction of service compositions
Authors: Li Jia , Luo Xin , Xia Yunni , Han Yakai , Zhu Qingsheng 
Published: January 2014

SUMMARYWeb services are emerging as a major technology for deploying automated interactions between distributed and heterogeneous applications. The accurate prediction of their quality of service (QoS) is important because their users rely on it to decide whether they meet the QoS requirement. The existing studies of QoS prediction usually assume that QoS of service activities follows certain distributions. These distributions are used as static model inputs into stochastic process models to obtain analytical QoS results. Instead, we consider the QoS activities to be fluctuating and introduce a dynamic framework to predict the runtime QoS by employing an Autoregressive Moving Average Model and QoS reduction rules. In the case study of a real‐world composite service sample, a comparison between existing approaches and the proposed one is presented, and results suggest that the proposed one achieves higher prediction accuracy.Copyright © 2014 John Wiley & Sons, Ltd.
Effective Surface Functionalization of Carbon Fibers for Fiber/Polymer Composites with Tailor‐Made Interfaces
Authors: Shiba Kota , Tagaya Motohiro , Samitsu Sadaki , Motozuka Satoshi 
Published: January 2014

AbstractComposites between carbon fibers (CFs) and heterogeneous materials have been widely studied and their fabrication techniques have been developed. However, their hydrophobic surfaces make it difficult to disperse CFs into hydrophilic resins, which results in weak junctions with ceramics. To develop high‐strength composite fibers, it is important to design interfacial chemical bonds. Thus, surface‐modification techniques of CFs have recently become the main focus and their interfaces have been characterized by various analytical methods. In this Minireview, various techniques that modify the CF surface by coating with inorganic polymers (metal oxide compounds) are highlighted, and the applications of novel nanocomposite fibers are also described. Furthermore, interfacial bonds between CFs and polymer resins are reviewed and discussed in terms of CF‐reinforced plastics and their future prospects.
A Measurable Impact of a Self‐Practice/Self‐Reflection Programme on the Therapeutic Skills of Experienced Cognitive‐Behavioural Therapists
Authors: Davis Melanie L. , Thwaites Richard , Freeston Mark H. , Bennett‐Levy James 
Published: January 2014

The need for effective training methods for enhancing cognitive‐behavioural therapist competency is not only relevant to new therapists but also to experienced therapists looking to retain and further enhance their skills. Self‐practice/self‐reflection (SP/SR) is a self‐experiential cognitive‐behavioural therapy (CBT) training programme, which combines the experience of practicing CBT methods on oneself with structured reflection on the implications of the experience for clinical practice. In order to build on previous qualitative studies of SP/SR, which have mainly focused on trainee CBT therapists, the aim of the current study was to quantify the impact of SP/SR on the therapeutic skills of an experienced cohort of CBT therapists. Fourteen CBT therapists were recruited to participate in an SP/SR programme specifically adapted for experienced therapists. In the context of a quasi‐experimental design including multiple baselines within a single‐case methodology, therapists provided self‐ratings of technical cognitive therapy skill and interpersonal empathic skill at four critical time points: baseline, pre‐SP/SR and post‐SP/SR and follow‐up. Analysis of programme completers (n = 7) indicated that SP/SR enhances both technical skill and interpersonal therapeutic skill. Further intention‐to‐treat group (n = 14) analyses including both those who left the programme early (n = 3) and those who partially completed the programme (n = 4) added to the robustness of findings with respect to technical cognitive therapy skills but not interpersonal empathic skills. It was concluded that SP/SR, as a training and development programme, could offer an avenue to further therapeutic skill enhancement in already experienced CBT therapists. Copyright © 2014 John Wiley & Sons, Ltd.Key Practitioner Message

It was possible to quantify the positive impact of a self‐practice/self‐reflection (SP/SR) training and development programme within a cohort of experienced cognitive‐behavioural (CBT) therapists.
Through SP/SR, experienced CBT therapists can further enhance their self‐perceived therapeutic skills in two key domains; technical cognitive therapy skills and interpersonal empathic skill.
Further SP/SR studies should aim to incorporate objective measurement of therapeutic skill, ideally from more than one rating source.
Regioselective Synthesis of Diversely Substituted Diazoninones Through a Post‐Ugi Gold‐Catalyzed Intramolecular Hydroarylation Process
Authors: Li Zhenghua , Kumar Amit , Vachhani Dipak D. , Sharma Sunil K. , Parmar Virinder S. , Van der Eycken Erik V. 
Published: January 2014

AbstractA highly efficient approach for the regioselective construction of fused nine‐membered rings (diazoninone framework) was developed by employing sequential Ugi and gold‐catalyzed intramolecular hydroarylation reactions. The scope of this intramolecular cyclization has been demonstrated.
One‐Pot Synthesis of N‐(Imidazo[1,2‐a]pyridin‐3‐yl)‐Substituted Sulfonamides Using Catalytic Zinc Chloride
Authors: Yu Chuanming , Chen Xu , Wu Ran , Yang Guanghui , Shi Jiaoyong , Pan Lingling 
Published: January 2014

AbstractA one‐pot two‐step synthesis of N‐(imidazo[1,2‐a]pyridin‐3‐yl)sulfonamides from easily available arylglyoxal hydrates, 2‐aminopyridines, and sulfonamides has been developed. The procedure, using zinc chloride as catalyst, is simple and inexpensive. The desired products were obtained in moderate to good yields under the optimized reaction conditions.
Partial least square and k-nearest neighbor algorithms for improved 3D quantitative spectral data–activity relationship consensus modeling of acute toxicity
Authors: Stoyanova-Slavova Iva B. , Slavov Svetoslav H. , Pearce Bruce , Buzatu Dan A. , Beger Richard D. , Wilkes Jon G. 
Published: January 2014

Abstract

A diverse set of 154 chemicals that included US Food and Drug Administration–regulated compounds tested for their aquatic toxicity in Daphnia magna were modeled by a 3-dimensional quantitative spectral data–activity relationship (3D-QSDAR). Two distinct algorithms, partial least squares (PLS) and Tanimoto similarity-based k-nearest neighbors (KNN), were used to process bin occupancy descriptor matrices obtained after tessellation of the 3D-QSDAR space into regularly sized bins. The performance of models utilizing bins ranging in size from 2 ppm × 2 ppm × 0.5 Å to 20 ppm × 20 ppm × 2.5 Å was explored. Rigorous quality-control criteria were imposed: 1) 100 randomized 20% hold-out test sets were generated and the average R2test of the respective models was used as a measure of their performance, and 2) a Y-scrambling procedure was used to identify chance correlations. A consensus between the best-performing composite PLS model using 0.5 Å × 14 ppm × 14 ppm bins and 10 latent variables (average R2test = 0.770) and the best composite KNN model using 0.5 Å × 8 ppm × 8 ppm and 2 neighbors (average R2test = 0.801) offered an improvement of about 7.5% (R2test consensus = 0.845). Projection of the most frequently occurring bins on the standard coordinate space indicated that the presence of a primary or secondary amino group—substituted aromatic systems—would result in an increased toxic effect in Daphnia. The presence of a second aromatic ring with highly electronegative substituents 5 Å to 7 Å apart from the first ring would lead to a further increase in toxicity. Environ Toxicol Chem 2014;33:1271–1282. © 2014 SETAC
Callocystites fresti sp. nov., and the significance of ambulacral branching in the Callocystitidae (Echinodermata, Glyptocystitoida)
Authors: Paul Christopher R. C. 
Published: January 2014

Callocystites fresti sp. nov. is characterized by an elongate theca, protuberant periproct and raised ambulacral facets. Ambulacral branching in Callocystites is isotomous, but left‐ and right‐handed branches occur because the ambulacral groove branches in the same direction twice, interrupting the regularly alternating branching to brachioles. Branching in Strobilocystites does not interrupt the alternation of brachioles and lateral food grooves always pass adoral to the first brachiole of each branch. Sphaerocystites branched as in Strobilocystites. Other morphological features suggest Callocystites, Sphaerocystites and Strobilocystites are not closely related. Callocystites has open infra‐lateral and lateral circlets and five ambulacra; Sphaerocystites and Strobilocystites have closed/modified circlets and four ambulacra. In Callocystites and Sphaerocystites the B and D ambulacra differ from the others and they have one hydropore; in Strobilocystites all four ambulacra are the same and the hydropore is double. All three genera have large, globular thecae. Ambulacral branching was a response to increased food‐gathering requirements. The following are phylogenetically informative callocystitid characters: truly open vs closed/modified plate circlets; number of pectinirhombs; number of ambulacra; presence vs absence of the ‘B D different’ pattern of primary brachioles; single vs double hydropore.In echinoderms with five ambulacra in a 2–1–2 pattern ambulacral homologies are unambiguous: the single amb is A (III). In echinoderms without this pattern or with less than five ambulacra the hydropore or a single gonopore is best for orientation. Both always occur in the CD (V‐I) interambulacrum. The position of the periproct is unreliable. Different patterns and numbers of ambulacra in Palaeozoic echinoderms render a single developmental sequence improbable. Cystoids (blastozoans) had radial water vessels in their ambulacra and added new ambulacral plates terminally. Functional morphological considerations suggest tube feet were essential for food gathering. Copyright © 2014 John Wiley & Sons, Ltd.
OUTSOURCING AND MARKET VALUE OF THE FIRM: TOWARD A COMPREHENSIVE MODEL
Authors: Nagpal Pankaj , Nicolaou Andreas I. , Lyytinen Kalle 
Published: January 2014

SUMMARYWe analyze the effect of buyer, contract, and vendor characteristics on abnormal stock returns among firms that have announced large scale Information Technology (IT) and Business Process outsourcing (BPO) contracts. We draw upon a comprehensive dataset on outsourcing announcements, augmented with data from public sources. Salient buyer factors examined include use of a wide range of organizational controls. On the vendor side, we examine the impact of vendor size, contract size and reputation. Our study shows that use of behavior controls, outcome controls (negative), vendor reputation, and industry of buyer firm affect market value. When limited to buyer related factors, use of behavior and clan controls is positively related to abnormal returns around IT outsourcing announcements. An interesting finding is that IT and BPO success require different sets of controls. Copyright © 2014 John Wiley & Sons, Ltd.
Regulation of coenzyme Q biosynthesis in yeast: A new complex in the block
Authors: González‐Mariscal Isabel , García‐Testón Elena , Padilla Sergio , Martín‐Montalvo Alejandro , Pomares‐Viciana Teresa , Vazquez‐Fonseca Luis , Gandolfo‐Domínguez Pablo , Santos‐Ocaña Carlos 
Published: January 2014

AbstractCoenzyme Q (CoQ) is an isoprenylated benzoquinone found in mitochondria, which functions mainly as an electron carrier from complex I or II to complex III in the inner membrane. CoQ is also an antioxidant that specifically prevents the oxidation of lipoproteins and the plasma membrane. Most of the information about the synthesis of CoQ comes from studies performed in Saccharomyces cerevisiae. CoQ biosynthesis is a highly regulated process of sequential modifications of the benzene ring. There are three pieces of evidence supporting the involvement of a multienzymatic complex in yeast CoQ6 biosynthesis: (a) the accumulation of a unique early precursor in all null mutants of the COQ genes series, 4‐hydroxy‐3‐hexaprenyl benzoate (HHB), (b) the lack of expression of several Coq proteins in COQ null mutants, and (c) the restoration of CoQ biosynthesis complex after COQ8 overexpression. The model we propose based on the formation of a multiprotein complex should facilitate a better understanding of CoQ biosynthesis. According to this model, the complex assembly requires the synthesis of a precursor such as HHB by Coq2p that must be recognized by the regulatory protein Coq4p to act as the core component of the complex. The phosphorylation of Coq3p and Coq5p by the kinase Coq8p facilitates the formation of an initial precomplex of 700 kDa that contains all Coq proteins with the exception of Coq7p. The precomplex is required for the synthesis of 5‐demethoxy‐Q6, the substrate of Coq7p. When cells require de novo CoQ6 synthesis, Coq7p is dephosphorylated by Ptc7p, a mitochondrial phosphatase that activates the synthesis of CoQ6. This event allows for the full assembly of a complex of 1,300 kDa that is responsible for the final product of the pathway, CoQ6. © 2014 IUBMB Life, 66(2):63–70, 2014
On the Existence of Friendship Hypergraphs
Authors: Jørgensen Leif Kjær , Sillasen Anita Abildgaard 
Published: January 2014

AbstractA 3‐uniform friendship hypergraph is a 3‐uniform hypergraph in which, for all triples of vertices x, y, z there exists a unique vertex w, such that , and are edges in the hypergraph. Sós showed that such 3‐uniform friendship hypergraphs on n vertices exist with a so‐called universal friend if and only if a Steiner triple system, exists. Hartke and Vandenbussche used integer programming to search for 3‐uniform friendship hypergraphs without a universal friend and found one on 8, three nonisomorphic on 16 and one on 32 vertices. So far, these five hypergraphs are the only known 3‐uniform friendship hypergraphs. In this paper we construct an infinite family of 3‐uniform friendship hypergraphs on 2k vertices and edges. We also construct 3‐uniform friendship hypergraphs on 20 and 28 vertices using a computer. Furthermore, we define r‐uniform friendship hypergraphs and state that the existence of those with a universal friend is dependent on the existence of a Steiner system, . As a result hereof, we know infinitely many 4‐uniform friendship hypergraphs with a universal friend. Finally we show how to construct a 4‐uniform friendship hypergraph on 9 vertices and with no universal friend.
Efficacy of 3D‐positron emission tomography/computed tomography for upper abdomen
Authors: Murakami Koji , Nakahara Tadaki 
Published: January 2014

Abstract Recent advancement in computed tomography (CT) enables us to obtain high spatial resolution image and made it possible to construct extensive high‐definition three‐dimensional (3D) images. But a lack of contrast resolution in CT alone is still remained problem. Meanwhile, as fluorodeoxyglucose‐positron emission tomography (PET) can visualize tumors in high contrast, we can create 3D images fusing the accumulation in tumors on PET/CT images. Such images can play the role of a “map of body” which makes it easy to understand the anatomical information before surgery. We also try to evaluate segmental liver function by using PET/CT fusion images. By using 11C‐methionine PET/contrast‐enhanced CT, superior image quality compared to single photon emission computed tomography/CT can be obtained. CT, especially with contrast enhancement for obtaining anatomical imaging information plus PET for obtaining functional imaging information is a highly compatible combination, and adding these two types information will further increase clinical usefulness.