bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transformación digital en la hacienda La Ciénega: mejores prácticas en gerencia de proyectos
Authors: Toaquiza Toaquiza Betty Fernanda , Tapia Tapia Mario Enrique , Ormaza Andrade Jorge Edwin 
Published: July 2024

Introducción: El artículo científico aborda la transformación digital dentro de la gerencia, como herramienta para fomentar el desarrollo de la hacienda La Ciénega, en especial en la trascendencia de las alianzas internacionales para aprovechar el crecimiento de las ventas en el servicio que ofrece la empresa. Las tecnologías digitales pueden contribuir a la mejora de la productividad, mediante un planteamiento centrado con los colaboradores de la empresa de tal manera que se promueva la eficiencia empresarial en cada uno de los procesos. A través de la experiencia real vivida que fue la pandemia del Covid-19, permitió descubrir la importancia que tiene la transformación digital dentro del ámbito laboral ya que dicha vivencia enseñó las diferentes maneras de comunicación con la transformación digital de los distintos países. La hacienda la Ciénega ha entrado en una crisis económica desde el coronavirus con un potencial de crecimiento limitado y pocas visitas de clientes. La transformación digital, ya sea una empresa, un proveedor de servicios debe responder a las necesidades cambiantes de sus clientes o a las tendencias del mercado, para obtener clientes satisfechos en el servicio que ofrece la hacienda la Ciénega, así mismo debe reconstruir las dinámicas de las organizaciones y poder adaptarse a las necesidades del presente y del futuro. Objetivo: Bajo las consideraciones antes descritas el objetivo de la presente investigación es diseñar una metodología de transformación digital aplicable a la Hacienda La Ciénega que promueva la eficiencia empresarial en cada uno de los procesos. Metodología: La investigación fue no experimental y se recopilaron y analizaron datos numéricos y estadísticos, así como información no numérica. Resultados: Los resultados evidencian el 35.8% de los encuestados afirman que la transformación digital se aplica en toda la organización y de forma integrada, mientras que el 64.2% indica que, si bien hay aplicación, esta se limita a algunas áreas o departamentos. Conclusiones: En conclusión, la transformación digital ha dejado claro que es más que una simple adopción de tecnología; es un cambio fundamental en la forma en que las organizaciones operan y entregan un valor considerable en mejorar la experiencia de sus clientes. Área de estudio general: Administración de empresa. Área de estudio específica: Dirección y gestión de proyectos
Propuesta de implementación de un enfoque DMF para la gestión documental en la Cooperativa JEP.
Authors: Godos Rosales Silvia Patricia , Castillo Ortega Yonimiler , Ormaza Andrade Jorge Edwin 
Published: July 2024

Introducción: La gestión eficaz de documentos constituye un elemento central en el funcionamiento de cualquier entidad, y la JEP Ltda. no es una excepción. En el contexto actual, donde la información se constituye como un activo estratégico, la habilidad para acceder, almacenar y administrar documentos de manera eficiente se convierte en un determinante para el desempeño organizacional. Objetivo: Evaluar un enfoque de Programa de Gestión Documental Gestión Documental Moderna (DMF) en la Cooperativa JEP para mejorar la eficiencia en el manejo de documentos, optimizando el acceso, la organización y la seguridad. Metodología: El estudio se caracterizó por tener un enfoque cuantitativo, y se empleó una encuesta adaptada de Caspi y Porras (2015); y Manrique y García (2023), dirigida a 137 empleados y gestores, de una población total de 250 personas en la cooperativa. Resultados: El análisis de la encuesta revela una actitud positiva hacia la adopción de tecnologías avanzadas en gestión documental, con un 67.9% esperando ahorro de tiempo. Existe un fuerte apoyo a la implementación de un sistema de gestión documental (97% de acuerdo) y la búsqueda de documentos es mayormente rápida, aunque hay margen de mejora. La integración de plataformas digitales es moderada y la ciberseguridad es altamente valorada, con un 69.2% considerándola muy importante. Conclusión: El análisis de la gestión documental en la Cooperativa JEP señaló varios desafíos, incluyendo la desorganización de la información, la ineficiencia en la búsqueda de documentos y la ausencia de integración tecnológica, por lo que se sugiere mejorar la eficiencia de la búsqueda a través de la formación del equipo y la adecuada aplicación de herramientas tecnológicas digitales. Área de estudio general: gestión empresarial. Área de estudio específica: gestión documental
Effects of Bacterial Fertilizer on the Growth And Absorption of Cadmium and Lead in Maize
Authors: Shi Xian , Meng Lingheng , Wang Tiantao , Tang Yanhua 
Published: July 2024

This study involed a simulated pot experiment to examine the effect of different levels of bacterial fertilizer application on the growth of maize. As per the results stated, SJ-1 or 0.35 g/kg should be the Maximum and SJ-4 or 2.25 g/kg should be the Minimum but both data points are being referred to as Maxima. As per the results CK and SJ-1 showed no difference and SJ-3 had the lowest but both SJ-1 and SJ-3 are stated to be the lowest. The bioconcentration factor (Pb) and transfer factor (Cd and Pb) in maize were reduced the most following the 2.25 g/kg treatment. The application of the bacterial fertilizer was found to reduce the pH and the amounts of EDTA-Cd and EDTA in the soil. The amount of the bacterial fertilizer applied was found to be positively correlated with the Cd and Pb contents in the underground parts. The results suggested that the correct application of the bacterial fertilizer could promote the growth of maize.
Bangladesh J. Bot. 53(2): 297-304, 2024 (June)
Morpho-Molecular Characterization of Endophytic Fungi From Three Traditional Medicinal Plants
Authors: Maria Zimatul , Shamsi Shamim , Hosen Sarowar , Bashar Md Abul 
Published: July 2024

The present study focuses on the occurrence of endophytic fungi harboured in the healthy tissues of the three medicinal plants, namely, Adhatoda vasica Nees, Cassia alata L., and Ocimum sanctum L., during the monsoon and winter seasons. Using the "Tissue Planting" method, 19 endophytic fungi were isolated from the leaves and stem of those plants and subsequently identified through morphological characteristics and molecular approaches. From all plants employed in this investigation, Aspergillus flavus, A. niger (Type I), A. niger (Type II), A. terreus, Colletotrichum sp., Penicillium sp.1, Pestalotiopsis mangiferae, and white sterile mycelium were isolated. To delve deeper, ten of these isolates underwent characterization via internal transcribed spacer (ITS) region amplification, and the sequence results obtained utilizing the ITS1 and ITS4 primers were cross-referenced with NCBI GenBank database system through BLAST analysis. The phylogenetic tree generated by the UPGMA method grouped the endophytic fungi into different clades on the basis of genetic distances. Cladosporium xanthochromaticum, Colletotrichum siamense, Fusarium incarnatum, and Talaromyces pinophilus have been recorded for the first time from Bangladesh. The primary findings of this investigation concerning endophytic fungi established a valuable foundation for further research exploring their potential ecological and biotechnological roles in various ecosystems, most importantly in drug discovery.
Bangladesh J. Bot. 53(2): 361-372, 2024 (June)
Teknologi Informasi, Partisipasi Manajemen, Dan Kemampuan Pemakai Sistem Informasi Akuntansi Terhadap Kinerja Karyawan Bagian Akunatansi
Authors: Choyrul Anuar  , Darman Usman  
Published: July 2024

This study aims to examine the influence of information technology, management participation, and the ability of users of accounting information systems on the performance of accounting employees. This study uses a quantitative approach. Respondents in this study were 40 accounting employees at the automotive company in the city of Bengkulu. This study collected primary data with a questionnaire. The selection of samples tested in this study using purposive sampling. The data were analyzed by using multiple linear regression analysis with SPSS program.
The results show the management participation has a positive effect on the performance of accounting employess,but information technology no influence on the performance of employees in the accounting department, and the ability of users of accounting information systems no influence the performance of employees in accounting,
ANALISIS DETERMINAN YANG BERHUBUNGAN DENGAN KINERJA TENAGA KESEHATAN DALAM MENEMUKAN KASUS TUBERKULOSIS DENGAN INVESTIGASI KONTAK
Authors: Putri Adelia Meutia , Budiati Endang , Adyas Atikah , Setiaji Bambang , Karyus Aila 
Published: July 2024

Indonesia menempati peringkat ke-2 jumlah kasus tuberkulosis tertinggi di dunia. Langkah yang perlu dilakukan dalam meningkatkan kinerja dalam menemukan penderita TBC dengan cara aktif adalah pelacakan dan investigasi kontak. Pada tahun 2022 case detection rate Tuberkulosis di Kabupaten Pesawaran menempati urutan ke-8 di Provinsi Lampung dengan jumlah penemuan kasus 585 (46,02%) dari target sebesar 1332. Penemuan penderita TBC yang belum mencapai target membutuhkan kinerja tenaga kesehatan yang baik untuk mengurangi beban Tuberkulosis. Teori determinan kinerja menurut Hersey dkk menyatakan beberapa faktor mempengaruhi kinerja dengan istilah ACHIEVE (Ability, Clarity, Help, Incentive, Evaluation, Validity, Environment). Penelitian menggunakan pendekatan kuantitatif dengan desain cross sectional. Sampel adalah pengelola Program Tuberkulosis Puskesmas dan perawat homecare sejumlah 90 responden yang diambil secara total sampling. Pengumpulan data menggunakan kuesioner. Analisis data secara univariat, bivariat dan multivariate. Hasil penelitian diketahui bahwa ada hubungan ability, clarity, help, incentive, validity, environment, dengan kinerja nakes dalam menemukan kasus Tuberkulosis dengan investigasi kontak, dan tidak ada hubungan antara evaluation dengan kinerja nakes. Variabel help, merupakan faktor dominan. Saran bagi dinas kesehatan agar melakukan pelatihan terutama kepada perawat homecare, melakukan supervise setiap bulan kepada kepala puskesmas, mengintegrasikan dan menyelaraskan upaya pengendalian Tuberkulosis dengan lintas sektor dalam penemuan kasus Tuberkulosis dengan investigasi kontak.
DNA structural features and variability of complete MHC locus sequences
Authors: Wassenaar Trudy M. , Harville Terry , Chastain Jonathan , Wanchai Visanu , Ussery David W. 
Published: July 2024

The major histocompatibility (MHC) locus, also known as the Human Leukocyte Antigen (HLA) genes, is located on the short arm of chromosome 6, and contains three regions (Class I, Class II and Class III). This 5 Mbp locus is one of the most variable regions of the human genome, yet it also encodes a set of highly conserved and important proteins related to immunological response. Genetic variations in this region are responsible for more diseases than in the entire rest of the human genome. However, information on local structural features of the DNA is largely ignored. With recent advances in long-read sequencing technology, it is now becoming possible to sequence the entire 5 Mbp MHC locus, producing complete diploid haplotypes of the whole region. Here, we describe structural maps based on the complete sequences from six different homozygous HLA cell lines. We find long-range structural variability in the different sequences for DNA stacking energy, position preference and curvature, variation in repeats, as well as more local changes in regions forming open chromatin structures, likely to influence gene expression levels. These structural maps can be useful in visualizing large scale structural variation across HLA types, in particular when this can be complemented with epigenetic signals.
Diagnosis of Brugada syndrome affects quality of life and psychological status
Authors: Berne Paola , Usai Francesca , Silva Etelvino , Melis Irene , Fancello Tatiana , Onida Alessandra , Merella Pierluigi , Figus Francesco , Brugada Josep , Casu Gavino 
Published: July 2024

BackgroundChronic diseases have a negative impact on quality of life (QOL) and psychological health. There are limited related data regarding this topic in Brugada syndrome (BrS). We evaluated the effects of the diagnosis of BrS on health-related QOL and psychological status among patients and their relatives.MethodsPatients with BrS and their relatives underwent psychological evaluation at diagnosis (T0), 1 and 2 years after diagnosis (T1 and T2) using questionnaires on mental QOL, anxiety, depression, stress, post-traumatic stress, and resilience resources.ResultsSixty-one patients and 39 relatives were enrolled. Compared with controls, patients showed increased physical QOL (54.1 ± 6.5 vs. 50.1 ± 8.0, p = 0.014), reduced mental QOL (43.2 ± 11.8 vs. 49.6 ± 9.1, p = 0.018) and increased anxiety (9.9 ± 6.6 vs. 6.9 ± 7.7, p = 0.024) at T0; reduced resilience scores (3.69 ± 0.40 vs. 3.96 ± 0.55, p = 0.008) at T1; and reduced resilience (3.69 ± 0.35 vs. 3.96 ± 0.55, p = 0.019) and increased anxiety scores (16.4 ± 12.8 vs. 6.9 ± 7.7, p = 0.006) at T2. Relatives presented higher stress (17.63 ± 3.77 vs. 12.90 ± 6.0, p = 0.02) at T0 and higher anxiety scores at T0 (13.5 ± 7.6 vs. 6.9 ± 7.7, p &lt; 0.001), T1 (12.0 ± 8.7 vs. 6.9 ± 7.7, p = 0.005), and T2 (16.4 ± 12.8 vs. 6.9 ± 7.7, p = 0.006) than controls. Female sex was significantly independently associated with worse mental QOL scores in patients at T0 (odds ratio = 0.10; 95% confidence interval = 0.05–0.94; p = 0.04).ConclusionsThe diagnosis of BrS impairs the QOL and psychological status of patients and their relatives. Female sex is independently associated with worse mental QOL in patients at diagnosis.
The existence of adrenal insufficiency in patients with COVID-19 pneumonia
Authors: Porntharukchareon Thachanun , Dechates Bothamai , Sirisreetreerux Supamas , Therawit Phonthip , Tawinprai Kriangkrai 
Published: July 2024

IntroductionInfection with SARS-CoV-2 virus may result in long COVID, a syndrome characterized by symptoms such as dyspnea, cardiac abnormalities, cognitive impairment, and fatigue. One potential explanation for these symptoms is hypocortisolism.ObjectiveTo evaluate the prevalence of hypocortisolism in patients with a history of COVID-19 pneumonia.MethodsCross-sectional study of patients who were aged ≥18 years and had a 3-month history of radiography-confirmed COVID-19 pneumonia. Exclusion criteria included current or previous treatment with glucocorticoids and use of an oral contraceptive. Adrenal function was evaluated using a low dose (1ug) corticotropin stimulation test (CST). Serum cortisol levels were measured at 0, 30, and 60 minutes, and baseline plasma ACTH was also measured.ResultsOf the 41 patients enrolled, the median age was 62 years, 17 (42%) were female, and all 41 (100%) had severe pneumonia at baseline. Eleven patients (27%) had hypocortisolism, as evidenced by peak cortisol of less than 402.81 nmol/l after low dose (1 µg) CST. Of these 11 patients, 10 (91%) had secondary hypocortisolism (median ACTH 6.27 pmol/L, range 4.98–9.95 pmol/L) and one had primary hypocortisolism (mean ACTH 32.78 pmol/L). Six of the 11 patients with hypocortisolism (54.5%) reported symptoms of persistent fatigue and 5 (45.5%) required regular glucocorticoid replacement.ConclusionsOur results suggest that hypocortisolism, predominantly caused by pituitary disruption, may emerge after SARS-CoV-2 infection and should be considered in patients with a history of COVID-19 pneumonia with or without clinical hypocortisolism.
Spatiotemporal evolution and driving factors of vegetation net ecosystem productivity in Henan Province over the past 20 years
Authors: Zhi Lu , Chai Yuanlong , Sun Chaowei , Li Runsheng , Hu Tao 
Published: July 2024

Net ecosystem productivity (NEP) is a crucial parameter for assessing the carbon cycle dynamics in terrestrial ecosystems. This study analyzed the spatial and temporal evolution characteristics and future trends of NEP in Henan Province over the past 20 years based on MOD17A3HGF, meteorological, and land-use data, employing the frequency counting method, trend test, Hurst index, and the center of gravity model. Various areas of changes in vegetation carbon sequestration were explored, and the driving factors were quantitatively assessed through correlation analysis, Sankey diagrams, and Geodetector. The results demonstrate that: 1) Continuous temporal changes in NEP in Henan, with annual average values fluctuating between 272.84 and 451.39 gC·m-2·a1, exhibiting an overall upward trend. 2) Spatially, there is a distinct distribution of NEP, concentrating more in the south and less in the north. While the study area generally experiences a dominant gradual enhancement of vegetation carbon sequestration capacity, the middle and north of Zhengzhou City exhibit a significant decline, which is expected to persist in the future. The migration of the centers of gravity of NEP over the past 20 years is characterized by stage-specific differentiation. 3) Among the various land cover types, forests have the strongest carbon sequestration capacity; however, cropland emerges as the province’s main source of NEP due to its extensive size. 4) The driving factors for spatial differentiation in NEP exhibit some temporal variability. Overall, climate factors and atmospheric pollution exert stronger influences, with the interactive explanatory power of the two-factor interaction being higher than that of the single factor. The results of this study can serve as a scientific theoretical basis for ecological policy-making and sustainable development in Henan Province.
Collagen concentration regulates neutrophil extravasation and migration in response to infection in an endothelium dependent manner
Authors: Calo Christopher J. , Patil Tanvi , Palizzi Mallory , Wheeler Nicola , Hind Laurel E. 
Published: July 2024

IntroductionAs the body’s first line of defense against disease and infection, neutrophils must efficiently navigate to sites of inflammation; however, neutrophil dysregulation contributes to the pathogenesis of numerous diseases that leave people susceptible to infections. Many of these diseases are also associated with changes to the protein composition of the extracellular matrix. While it is known that neutrophils and endothelial cells, which play a key role in neutrophil activation, are sensitive to the mechanical and structural properties of the extracellular matrix, our understanding of how protein composition in the matrix affects the neutrophil response to infection is incomplete.MethodsTo investigate the effects of extracellular matrix composition on the neutrophil response to infection, we used an infection-on-a-chip microfluidic device that replicates a portion of a blood vessel endothelium surrounded by a model extracellular matrix. Model blood vessels were fabricated by seeding human umbilical vein endothelial cells on 2, 4, or 6 mg/mL type I collagen hydrogels. Primary human neutrophils were loaded into the endothelial lumens and stimulated by adding the bacterial pathogen Pseudomonas aeruginosa to the surrounding matrix.ResultsCollagen concentration did not affect the cell density or barrier function of the endothelial lumens. Upon infectious challenge, we found greater neutrophil extravasation into the 4 mg/mL collagen gels compared to the 6 mg/mL collagen gels. We further found that extravasated neutrophils had the highest migration speed and distance in 2mg/mL gels and that these values decreased with increasing collagen concentration. However, these phenomena were not observed in the absence of an endothelial lumen. Lastly, no differences in the percent of extravasated neutrophils producing reactive oxygen species were observed across the various collagen concentrations.DiscussionOur study suggests that neutrophil extravasation and migration in response to an infectious challenge are regulated by collagen concentration in an endothelial cell-dependent manner. The results demonstrate how the mechanical and structural aspects of the tissue microenvironment affect the neutrophil response to infection. Additionally, these findings underscore the importance of developing and using microphysiological systems for studying the regulatory factors that govern the neutrophil response.
Effectiveness of a hybrid emergency room system in the management of acute ischemic stroke: a single-center experience
Authors: Kashiura Masahiro , Nakajima Chisato , Kishihara Yuki , Tominaga Keiichiro , Tamura Hiroyuki , Yasuda Hideto , Ikota Masashi , Yamada Kenji , Yoshino Yoshikazu , Moriya Takashi 
Published: July 2024

IntroductionHybrid emergency room systems (HERSs) have shown promise for the management of severe trauma by reducing mortality. However, the effectiveness of HERSs in the treatment of acute ischemic stroke (AIS) remains unclear. This study aimed to evaluate the impact of HERSs on treatment duration and neurological outcomes in patients with AIS undergoing endovascular therapy.Materials and methodsThis single-center retrospective study included 83 patients with AIS who were directly transported to our emergency department and underwent endovascular treatment between June 2017 and December 2023. Patients were divided into the HERS and conventional groups based on the utilization of HERSs. The primary outcome was the proportion of patients achieving a favorable neurological outcome (modified Rankin Scale score 0–2) at 30 days. The secondary outcomes included door-to-puncture and door-to-recanalization times. Univariate analysis was performed using the Mann–Whitney U test for continuous variables and the chi-squared test or Fisher’s exact test for categorical variables, as appropriate.ResultsOf the 83 eligible patients, 50 (60.2%) were assigned to the HERS group and 33 (39.8%) to the conventional group. The median door-to-puncture time was significantly shorter in the HERS group than in the conventional group (99.5 vs. 131 min; p = 0.001). Similarly, the median door-to-recanalization time was significantly shorter in the HERS group (162.5 vs. 201.5 min, p = 0.018). Favorable neurological outcomes were achieved in 16/50 (32.0%) patients in the HERS group and 6/33 (18.2%) in the conventional group. The HERS and conventional groups showed no significant difference in the proportion of patients achieving favorable neurological outcomes (p = 0.21).ConclusionImplementation of the HERS significantly reduced the door-to-puncture and door-to-recanalization times in patients with AIS undergoing endovascular therapy. Despite these reductions in treatment duration, no significant improvement in neurological outcomes was observed. Further research is required to optimize patient selection and treatment strategies to maximize the benefits of the HERS in AIS management.