bluuebunny/crossref_metadata_2025_split huggingface dataset:
Química: su importancia en la humanidad
Authors: Garcia Ordaz Maria Irma 
Published: July 2024

La química ha estado presente en nuestras vidas, desde todos los tiempos aun sin la existencia de la humanidad, ésta ha tenido un gran impacto en la evolución de la tierra, gracias a las reacciones químicas se puede afirmar ¿Cómo la evolución química ha impactado en la historia del planeta? Podemos considerar a la química de suma importancia en cada una de las áreas de la industria de la transformación de la materia prima por ejemplo la química en la medicina, la química en tecnología, la química y el medio ambiente, la química en la alimentación y la agricultura, dando un gran beneficio en la sociedad, siendo así la química importante en la vida cotidiana, ya que la química ha otorgado grandes aportaciones a la humanidad, siendo la química fundamental en la composición, estructura y transformación de la materia, razón por la cual la materia al ser transformada ha permitido la evolución de la propia humanidad.
En cualquiera de los campos en que se interponga a la química, como parte de un proceso ya sea industrial, medico ambiental o cotidiano, es importante considerar que su impacto puede ser tanto a favor, como en contra, ya que, si bien es cierto una persona al necesitar un fármaco como parte de un tratamiento, le puede crea adicción al no tener un tratamiento adecuado.
La química se encuentra presente en todas partes, siendo importante en vida cotidiana, ya que nos ayuda a comprender y controlar muchos aspectos tanto de nuestro cuerpo como del espacio o medio ambiente ¿Qué tanto afecta el metabolismo en nuestra salud? ¿Nuestros estilos de vida alimenticios impactan en la salud? ¿La química ha evolucionado a la par con la humanidad?
Importancia de educación con valores en el nivel medio superior
Authors: Vital Carrillo Marisela 
Published: July 2024

En la educación es importante que los alumnos aprendan a aprender, por ello en el nivel medio superior día a día se estableces nuevas estrategias con el propósito de promover la preparación de las nuevas generaciones, sin olvidar que uno de los temas principales son los valores, es importante conocer que el valor es una cualidad, una virtud o talento de las personas, y los valores son principios que caracterizan a una persona y que se consideran positivos o negativos ante la sociedad, estos van a permitir reforzar la personalidad de los alumnos de este nivel para enfrentarse al nivel superior.
Pelatihan Pembuatan Lilin Aromaterapi Essensial Oil Lavender di Dusun Kiringan, Canden, Jetis, Bantul Yogyakarta
Authors: Hidayati Listiana , Fatimah Fitri Andriani 
Published: July 2024

Lilin aromaterapi minyak essensial lavender bekerja dengan mempengaruhi kerja otak. Aromaterapi lavender yang harum dan segar memberikan banyak manfaat bagi kesehatan psikologis seseorang. Tujuan dari pelatihan ini adalah untuk memaksimalkan kekayaan alam tanaman obat serta meningkatkan ekonomi masyarakat baik Usaha Mikro Kecil Menengah (UMKM) maupun yang berbadan hukum di Desa Wisata Kiringan serta dapat menarik konsumen baru dari berbagai kalangan. Metode yang digunakan dalam pelatihan ini adalah: melakukan wawancara terkait kebutuhan terkait, penyuluhan, demonstrasi terbimbing, praktek langsung dan pendampingan. Hasil dari kegiatan sosialisasi ini adalah meningkatkan kemandirian ekonomi dan mengaplikasikan produksi lilin aromaterapi minyak essensial oil lavender UMKM warga Dusun Kiringan, Kelurahan Canden, Kecamatan Jetis, Kabupaten Bantul, Yogyakarta
Cell-based medicinal products: a review of current research
Authors: Galitsyna E. V. , Kulikova E. A. , Pavelyev Yu. A. , Kuznetsova O. S. , Senina A. S. , Gusev A. B. 
Published: July 2024

INTRODUCTION. Cell therapies and tissue-engineered products are aimed at patients with severe conditions (genetic and neurodegenerative disorders, cancers, musculoskeletal injuries, burns, etc.) that lack alternative treatment options. Analysis of clinical efficacy data on cell-based medicinal products is important for understanding their translational potential in personalised medicine.AIM. This study aimed to review key trends in cell therapy, analyse data on approved cell therapies and tissue-engineered products, and assess challenges and prospects for their use.DISCUSSION. This article analyses data on the composition of cell therapies and tissue-engi­neered products, indications for their use, and the results of clinical studies. Cell-based medicinal products are derived from autologous or allogeneic mesenchymal and limbal stem cells, epithelial cells, chondrocytes, native or genetically engineered haematopoietic stem cells, geneti­cally engineered lymphocytes (CAR-T, CAR-NK), etc. Medicinal products based on cell technologies have been approved in many countries, including the USA (approximately 30), the European Union (approximately 20), Japan (18), South Korea (15), etc. As of today, two cell therapies have been granted marketing authorisation in the Russian Federation. The first is based on CAR-T cells (a gene therapy product), and the other is based on chondrocytes (a cell-based medicinal product); the latter has been developed in Russia. The main advantages of cell therapy products include higher efficacy and fewer adverse drug reactions in comparison with standard treatment modalities. The main challenges of cell therapy include the risks of immune reactions and mutagenesis associated with lentiviral vectors or CRISPR/Cas9 technology, as well as limited efficacy of CAR-T and CAR-NK cells due to immunosuppressive properties of tumour microenvironment.CONCLUSION. In comparison with conventional treatment approaches, the use of cell therapies and tissue-engineered products can help effectively eliminate defects in various body tissues, avoid highly invasive surgical interventions, and reduce regeneration time. Thus, ensuring development of similar but at the same time more affordable Russian medicinal products can bring great benefits for the healthcare system of the Russian Federation.
Prediction of risks of comorbidity of type 2 diabetes mellitus and coronary heart disease taking into account plasma levels of 8-isoprostane and sirtuin-1
Authors: Zhuravlyova L. V. , Kucherenko S. M. 
Published: July 2024

Cardiovascular diseases (CVD), including coronary heart disease (CHD), continue to be the major causes of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Both CHD and T2DM are the most dangerous and widely spread conditions. According to research data, a high overall prevalence of CVD in type 2 DM has been established, with CHD as the most prevalent CVD type.
Objective — to determine the prognostic possibilities of estimation the risks of the development of coronary heart disease and type 2 diabetes comorbidity and to work out an appropriate prognostic model.
Materials and methods. A randomized controlled single‑center prospective case‑control study was conducted, Examinations involved 100 patients, allocated into two groups: subjects of the 1st group (n=30) had isolated CAD, and patients from the 2nd group (n=70) had CAD against the T2DM background. The control group consisted of 20 practically healthy subjects. Assessments included sirtuin‑1 and 8‑isoprostane levels. Statistical analysis of the obtained data was performed using the IBM SPSS 25.0 application program package for Windows.
Results. The following significant predictors of the development of CHD and T2DM comorbidity were determined: patients’ age (increased the probability by 7.1%) and body mass index (BMI, which increased the probability by 13.3%). The higher risk of CHD and T2DM was defined with the increasing 8‑isoprostane levels and decreasing sirtuin‑1 levels by 2.1% and 79.4%, respectively. In comparison with II functional class (FC) angina pectoris, the presence of III FC significantly (p=0.005) associated with a 66.3% decrease in the probability of the developing of CHD and T2DM comorbidity. In the combined analysis, the overall effect on the probability of developing CHD and T2DM comorbidity was determined with an increase in age by 8.1%, BMI by 18.9%, 8‑isoprostane by 2.6%, and a decrease in sirtuin‑1 by 81.0%, and presence of ІІІ FC of angina pectoris — by 82.8%. A mathematical equation for predicting the development of the comorbid course of CHD and T2DM has been worked out.
Conclusions. Patients’ age, body mass index, levels of 8‑isoprostane and sirtuin‑1, presence of III FC angina pectoris have been established as the most important predictors of the development of coronary heart disease and type 2 diabetes comorbidity.
Stress-induced dyslipidemia in chronic kidney disease during the war: mechanisms, clinical consequences, piculiarities of correction. Review
Authors: Chernyshov V. A. 
Published: July 2024

The article is devoted to discussion of actual questions of mental and physical stress exertion on dyslipidemia (DLP) phenotype peculiar to chronic kidney disease (CKD) during a war as well as to discussion of clinical consequences of lipid profile changes induced by mentioned stress factors and peculiarities of stress‑induced DLP correction in persons with CKD in the conditions of military time.
Complex mechanisms of interaction between stress hormones, insulin, cytokines and metabolism of fat tissue influenced on lipid profile changes in stress‑induced DLP have been considered. Such clinical consequences of stress‑induced DLP in patients with CKD in military time as atherosclerosis, glomerulosclerosis and thromboembolic complications were discussed. Atherogenic effects of stress include NO deficit, vascular endothelial production of cytokines, mitogenesis of vascular smooth muscle cells, insulin resistance, neuropeptide Y effects and modulation of renin‑ angiotensin‑aldosterone system. All these effects are connected with stress‑induced DLP. That’s why it’s important to block or minimize atherogenic action of stress components to save a structure and function of vascular endothelium and vascular wall. A negative influence of unhealthy lifestyle, typical during a war, on lipid profile and efficacy of hypolipidemic interventions is emphasized. The main areas of lifestyle modification, which should be followed even during the war, have been highlighted. The data about peculiarities of the use of hypolipidemic agents to save renal function and to reduce proteinuria have been presented in the paper. Some peculiarities have been elucidated as regards the choice of hypolipidemic drugs, including statins, fibrates, PCSK9 inhibitors and omega‑3 polyunsaturated acids, depending on their renal excretion, CKD stage, DLP phenotype and category of cardiovascular risk. Contemporary European recommendations for DLP correction in individual groups of patients with CKD included dialysis and renal transplantation have been discussed.
Analisis Nilai Tambah Ubi Kayu Sebagai Bahan Baku Keripik Singkong Balado Di Kecamatan Tenayan Raya Kota Pekanbaru
Authors: Saragih Rayhans , Tety Ermi , Muwardi Didi 
Published: July 2024

This study aims to (1) describe the profile of spicy cassava chips businesses in the Tenayan Raya District. (2) Understand the process of making spicy cassava chips in the Tenayan Raya District. (3) Analyze the production costs and revenue generated by the spicy cassava chips agro-industry in the Tenayan Raya District. (4) Analyze the added value of cassava chips from cassava processing into spicy cassava chips in the spicy cassava chips agro-industry in the Tenayan Raya District. The data analysis used in this research includes business income analysis, business efficiency analysis, and value-added analysis. The data used in this research are primary data in the form of interviews and secondary data from research journals. The conclusions of this study are as follows: (1) There are three spicy cassava chip businesses in the Tenayan Raya District, namely "KUB Sejahtera Cassava Chips Business," "Bu Sholihatun Cassava Chips Business," and "Mas Huryanto Cassava Chips Business." (2) The production process of spicy cassava chips in the Tenayan Raya District includes raw material selection, peeling and washing, cutting, frying, seasoning, and packaging. (3) The average production cost of spicy cassava chips in the Tenayan Raya District is Rp 2,978,008.60, with an average income of Rp 8,093,333. (4) The percentage of added value of the spicy cassava chips agro-industry in the Tenayan Raya District is 43.88%, indicating that the added value of the spicy cassava chips agro-industry in the Tenayan Raya District is still relatively low.
नेतृत्व विकासमा सनातन ग्रन्थको मार्गदर्शन {Guidance of Sanatan Granth on Leadership Development}
Authors: भट्टराई Battarai कमल प्रसाद Kamal Prasad 
Published: July 2024

नेतृत्व मानव सभ्यतासँगै विकास हुँदै आएको अवधारणा हो। सनातन एवम् पौराणिक ग्रन्थ शास्त्रहरु देखि नै नेतृत्वका आधारभूत सिद्धान्तहरुको प्रतिपादन हुँदै आएको पाइन्छ। सनातन दर्शन वा ग्रन्थ अनुसार एउटा समाजको ससानो सङ्गठनदेखि राष्ट्र र बहुराष्ट्र (राज्य, साम्राज्य, लोक, परलोक) सम्मको समग्र विकासको मार्गदर्शन गर्न सक्‍ने बुद्धिमान र धार्मिक (Righteous)व्यक्तित्व नै नेता/राजा/ शासकका रुपमा चित्रण हुँदै आएको छ। यस लेखमा नेता भन्नाले राष्ट्रियदेखि स्थानीयसम्म र बृहत् सङ्गठनदेखि सूक्ष्म सङ्गठनसम्मको तह वा निकायलाई अगाडि बढाउने वा व्यवस्थापन गर्ने जिम्मा पाएको वा लिएको अग्रदुतलाई इङ्गित गरिएको छ र त्यस्तो अग्रदुतको कार्यलाई नेतृत्व भनिएको छ। प्रस्तुत लेखमा नेतृत्वका आधुनिक सिद्धान्तहरु, नेतृत्वका सर्वोत्कृष्ट गुणहरु, आधुनिक नेतृत्वमाथि हुने गरेका आलोचनाहरूको चर्चा गर्दै वैदिक कालदेखिका सनातन ग्रन्थहरुमा नेतृत्वका विषयमा के कस्ता गुणहरु उल्लेख गरिएको थियो भन्ने विषय प्रस्तुत गरिएको छ। यसरी विश्लेषण गर्दा प्रभावकारी नेतृत्वमा हुनुपर्ने गुणहरु, आधुनिक समाज रुपान्तरणका लागि नेतृत्वले सामना गर्नुपर्ने चुनौतीको व्याख्या गर्दै वैदिक एवम् सनातन ज्ञानबाट नेतृत्व कौशलका बारेमा के कुरा सिक्‍न सकिन्छ र त्यस्तो ज्ञानबाट दीक्षित असल नेताले कसरी प्रभावकारी मार्गदर्शन प्रदान गरी सफल नेतृत्व प्रदान गर्न सक्छ भन्ने विषयमा चर्चा गरिएको छ। सनातन ग्रन्थहरुले समग्रमा नेतृत्वको सार नै “सर्वेभवन्तु सुखिन ” अर्थात् नेतृत्वको अन्तिम लक्ष्य आफू र जगतको वास्तविकतालाई वा ब्रम्हसत्यलाई बुझ्नु र त्यसैअनुरुप आफूले नेतृत्व गरेका क्षेत्रको समग्र शान्ति र समृद्धिका लागि योगदान दिनु हो भन्ने चर्चा गरेका छन्। नेतृत्वमा वैराग्य, आत्मज्ञान, करुणा, प्रज्ञा निष्काम कर्मलगायतका असाधारण गुणहरु हुन आवश्यक रहेको हुन्छ साथै त्यस्ता गुणहरुले युक्त भएका नेताले मात्र दिगो र प्रभावकारी नेतृत्व प्रदान गर्न सक्दछ भन्ने कुरामा जोड दिंदै सनातन ग्रन्थहरु एकमतले नेताको विकल्पमा समेत धारणा राख्दछन्। शास्त्रका अनुसार यदि नेतामा असल गुणहरु भएनन् भने त्यस्तो नेताले समाजको बृहत्तर शान्ति र अग्रगमनका लागि मार्ग प्रशस्त गर्न नसक्ने हुनाले समाजमा समयानुकुल सुव्यवस्थाका लागि नवीन नेतृत्वको जन्म हुँदै जान्छ भनेर श्लोकका माध्यमवाट “यदा यदा हि धर्मश्य ग्लानिर्भवति भारत, अभ्युत्थानमधर्मश्य तदात्मानं सृजाम्यहमः” भनिएको छ।यस श्लोकले इङ्गित गरेअनुसार समसामयिक नेतृत्वले समाजलाई सुव्यवस्थातर्फ डोर्याउन नसक्ने हो भने उक्त श्लोकले भने झैँ समयचक्रले पुराना नेतालाई पाखा लगाउँदै र नयाँ नेतृत्वलाई जन्माउँदै समाज निरन्तर अगाडि बढ्दै आएको र भविष्यमा पनि यसैअनुसार नेतृत्व विकास हुँदै जाने हुनाले नेतृत्वलाई सजगता प्रदान गर्न यस लेखको उद्देश्य रहेको छ।
ОСОБЛИВОСТІ ВТІЛЕННЯ ШЕКСПІРІВСЬКИХ ОБРАЗІВ В ОПЕРНОМУ МИСТЕЦТВІ У СЕРЕДИНІ – ДРУГІЙ ПОЛОВИНІ ХVII СТОЛІТТЯ: ІНТЕРПРЕТАТИВНИЙ АСПЕКТ
Authors: Shyiuan Sun 
Published: July 2024

Метою роботи є вивчення особливостей втілення образів шекспірівських творів у світовому оперному мистецтві з виділенням як провідних принципів інтерпретації літературного першоджерела засобами оперного жанру. Методологія статті базується на музично-історичному, історіографічно-джерелознавчому та музично-текстологічному підходах, що створює підстави для поглибленого жанрово-стильового та музично-мовного аналізу оперних текстів на шекспірівські сюжети. Посилення уваги до драматургічних та художньо-образних особливостей шекспірівських текстів дає можливість значно поглиблювати вивчення оперної спадщини, в основі якої лежать дані тексти, що в свою чергу стає підґрунтям для багатьох сценічних втілень та інтерпретативних рішень даних творів. Наукова новизна даної статті обумовлюється вивченням художньо-образних особливостей інтерпретації шекспіровських сюжетів у оперному мистецтві, що дає можливості виділяти засадничі риси шекспіріани як особливої галузі музичного мистецтва. Висновки. Вплив Вільяма Шекспіра на світове театральне мистецтво, у тому числі й музичне, залишається безпрецедентним та надзвичайно масштабним. Його талант, натхнення та глибоке розуміння людської душі зробили його одним із найбільших драматургів в історії мистецтва, що підтверджують багаточисленні звернення до шекспірівських текстів та системи шекспірівських образів з боку митців, що належать до різних художніх напрямів та спеціалізацій. Перші художньо-сценічні експерименти з текстами В. Шекспіра, які відбуваються у музичному театрі середини – другої половини ХVII століття, суттєво вплинули на розвиток музично-театральних жанрів, у тому числі стали одним зі значних факторів формування semi-oпeри. Як відомо, у драматичних п’єсах з музикою того часу співвідношення драматичного та музичного компонентів дуже часто схилялося у бік драматичного, а музика виконувала додаткову та інтермедійну функцію. Разом з тим, саме у добу Реставрації ці дві рівні музично-театрального твору починають наближуватися одна до одної, утворюючи таке нове жанрове явище як semi-опера.
Experience of Literary Reception of New Testament Texts. Wreath of Sonnets on 1 Cor. St. Apostle Pau
Authors: Рупова Розалия Моисеевна 
Published: July 2024

Вниманию читателей предложен современный литературный опыт переложения Первого послания к Коринфянам св. апостола Павла на язык поэзии. В качестве поэтической формы для этой цели автором избрана наиболее сложная форма венка сонетов. В предисловии к самому тексту приводится обоснование предпочтения этой формы другим, краткий абрис ее истории и теории, а также проблематика литературной рецепции Священного Писания и, особенно, новозаветных текстов.
Readers are offered a modern literary experience of the translation of the First Epistle to the Corinthians by St. Apostle Paul into the language of poetry. As a poetic form, the author chose for this purpose the most complex form of a sonnet wreath. The preface to the text itself provides a rationale for the preference of this form over others, a brief outline of its history and theory, as well as problems of literary reception of the Holy Scriptures and, especially, the texts of the New Testament
Review of: Shmid G. Y., archpriest. The Theology of St. Luke, Evangelist and Deist: a study guide / Archpriest George Shmid; St. Petersburg Theological Academy, Department of Biblical Studies. St. Petersburg: St. Petersburg Theological Academy, 2023. 492
Authors: Ковшов Михаил Всеволодович 
Published: July 2024

До сих пор на русском языке не было ни одного специального пособия по Богословию св. Луки, Евангелиста и Дееписателя, поэтому появление рецензируемого учебника нельзя не приветствовать. Тем более, что написано оно признанным специалистом своего дела, доцентом кафедры библеистики СПбДА протоиереем Георгием Шмидом.
Until now there has not been a single special textbook on the Theology of St Luke, the Evangelist and Deuteronomist in Russian, so the appearance of the textbook under review cannot but be welcomed. All the more so because it is written by a recognised expert in his field, Archpriest George Schmid, Associate Professor of the Department of Biblical Studies at St. Luke's Academy of Biblical Studies.
The Elements of Specialization in the Bachelor’s Degree Program: The Experience of the Moscow Theological Academy
Authors: Лизгунов Павел 
Published: July 2024

В статье в контексте диалектики универсального и специализированного рассматривается учебный план бакалавриата духовных учебных заведений Русской Церкви. Объясняется необходимость сочетания универсализма Единого учебного плана бакалавриата с элементами специализации различного профиля. Рассмотрены различные варианты внедрения ранней специализации: вариативная часть учебного плана, программы дополнительного образования, факультативы. Описан опыт МДА по разработке системы факультативов, соответствующим последующим магистерским программам.
The article examines the undergraduate curriculum of theological educational institutions of the Russian Church in the context of the dialectic of the universalization and the specialization. The necessity of combining the universalism of the Unified Bachelor’s Curriculum with the elements of different specializations is explained. Various options for introducing early specialization are considered. Among them are: the variable part of the curriculum, the additional education programs, the electives. The experience of MDA in developing a system of electives corresponding to subsequent master’s programs is described
Church Legal Consciousness Through the Prism of Paired Categories «Culture — Anticulture»
Authors: Ерохина Ю.В. 
Published: July 2024

Рассматриваются определение и роль церковного правосознания в контексте исторического и современного противостояния культуры и антикультуры, ценностей и антиценностей. Парные категории «культура — антикультура» анализируются в контексте праксеологического и аксиологического подходов на основании эмпирических фактов и корреляции с церковным правосознанием. Выявляется одно из направлений, по которому ведётся воздействие антикультуры, в том числе и на церковное правосознание. Проводится синтез компонентов церковного правосознания, церковного права и культуры в соответствии с положениями теории права, философии права и экклезиологии. Внимание в исследовании обращается к одной из актуальных проблем изучения церковного права, сформировавшейся в отдельное научное направление «Церковное право и культура» в рамках деятельности Барсовского общества[1]. Статья написана на основании доклада, представленного на III Всероссийской ежегодной научно-практической конференции «Юстиниановские чтения», посвящённой вопросам канонического права и литургики (Московская духовная академия, 27–28 ноября 2022 г.)
The definition and role of church legal consciousness in the context of the historical and modern confrontation between culture and anti-culture, values and anti-values are considered. Paired categories “culture — anti-culture” are analyzed in the context of praxeological and axiological approaches based on empirical facts and correlation with church legal consciousness. One of the directions in which the impact of anti-culture is being carried out, including on church legal consciousness, is revealed. The synthesis of the components of church legal consciousness, church law and culture is carried out in accordance with the provisions of legal theory, philosophy of law and ecclesiology. Attention in the study is drawn to one of the topical problems of the study of church law, which was formed into a separate scientific direction “Church Law and Culture” within the framework of the activities of the Barsov Society. The article is written on the basis of a paper presented at the III All-Russian Annual Scientific and Practical Conference “Justinian's Readings” devoted to the issues of canon law and liturgics (Moscow Theological Academy, November 27-28, 2022).