bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fanconi syndrome with biopsy-proven acute proximal tubular injury induced by a dietary supplement containing beni-koji: a case series report
Authors: Habuka Masato , Hosojima Michihiro , Yata Yusuke , Kurumada Kenshiro , Yamagiwa Moeri , Yonezawa Masataka , Sudo Masanori , Kabasawa Hideyuki , Ogawa Asa , Hama Hitomi , Ito Yumi , Imai Naofumi , Yamamoto Suguru , Saito Akihiko , Goto Shin 
Published: August 2024

Abstract

Background: Fanconi syndrome is a disorder of the proximal tubule that leads to malabsorption of various electrolytes and substances and is a common consequence of drug-induced nephrotoxicity. However, cases of dietary supplement-induced Fanconi syndrome are rare, and there have been no reports of evaluation of renal histology in patients with this syndrome.
Case presentation: We present two cases of dietary supplement-induced Fanconi syndrome that was confirmed by kidney biopsy. Based on their medical history and laboratory and histological findings, both cases were diagnosed as acute proximal tubular injury caused by ingestion of a lipid-lowering dietary supplement containing beni-koji, leading to Fanconi syndrome. Both patients improved after discontinuation of the dietary supplement and correction of dehydration and electrolyte imbalance.
Conclusions: Clinicians should consider dietary supplement-induced Fanconi syndrome as a differential diagnosis in patients who become ill while taking dietary supplements. Kidney biopsy is useful for diagnosing dietary supplement-induced Fanconi syndrome and exploring its pathogenesis.
The effects of complement-independent, autoantibody-induced apoptosis of platelets in immune thrombocytopenia (ITP)
Authors: Sun Lin , Zhang Yi , Chen Ping , Jiang Nan , Feng Qi , Xu Shu , Peng Jun , Sheng Zi 
Published: August 2024

Abstract

Autoantibodies that cause platelet apoptosis may play a role in the development of immune thrombocytopenia (ITP), specifically antibodies that target GPIIbIIIa and GPIbα. Our research aims to compare the impact of the antigen specificity of antiplatelet antibodies on normal platelets under conditions that do not rely on complement. Using a modified monoclonal antibody-specific immobilization of platelet antigen (MAIPA) assay, we detected the levels of autoantibodies against specific platelet membrane glycoproteins (GPIIb/IIIa, GPIb/IX) in the plasma of 36 patients diagnosed with chronic ITP. IgG was isolated and purified using a protein A agarose affinity chromatography column, and their concentrations were measured using spectrophotometry. We obtained normal platelets and treated them with the purified IgG anti-GPIIb/IIIa and/or anti-GPIb/IX antibodies, as well as an IgG-free buffer and healthy control IgG. Flow cytometry was used to analyze markers of apoptosis, including phosphatidylserine (PS) exposure, mitochondrial inner membrane potential (ΔΨm), and platelet particle formation. Our results indicate that ITP patients with GPIb/IX-specific autoantibodies can induce platelet apoptosis and platelet particle formation through complement-independent pathways, which are not associated with platelet activation, while GPIIb/IIIa-specific autoantibodies did not have this effect. This suggests that specific autoantibodies may serve as a valuable predictive tool to identify patients who could potentially benefit from complement-inhibiting therapy in the future.
Clinical outcomes of preserving antral branch of right gastroepiploic vein in laparoscopic pylorus-preserving gastrectomy: a retrospective analysis
Authors: Liu Xu , Zhuang Chun , Yu Feng-rong , Xia Xiang , Xu Jia , Zhao En-hao , Cao Hui , Zhao Gang , Wang Chao-jie , Zhu Chun-chao 
Published: August 2024

Abstract

Background
Delayed gastric emptying (DGE) is a significant complication in pylorus-preserving gastrectomy (PPG) which disturb the postoperative recovery. We modified the infrapyloric dissection to preserve the antral branch of right gastroepiploic vein (RGEV) in PPG as a preventive method of DGE and investigate the clinical outcomes.
Methods
Preservation of the antral branch of RGEV was reviewed of cT1N0M0 gastric cancer patients underwent PPG (n = 131) by a single surgeon during 2018–2020. Presence of DGE was evaluated by postoperative complications, gastric emptying scintigraphy (GES) and gastroscopy. DGE were compared between the antral branch preserved (a-PPG) group (n = 67) and sacrificed (c-PPG) group (n = 64). Clinicopathological features were also compared.
Results
Overall complication rate was similar between a-PPG and c-PPG group (p = 0.631). No one suffered from DGE with Grade Ⅲ in a-PPG group (0.0%) comparing with 5 cases in c-PPG with Grade III DGE (7.8%) (p = 0.026). The number of retrieved No.6 lymph nodes and 3-year recurrence-free survival were similar between two groups. At postoperative 3 months, DGE detected by GES was more frequent in c-PPG (23.8%) than in a-PPG (6.3%) (p = 0.032). Antral branch preservation (p = 0.037) was an independent risk factor of DGE according to multivariate analysis.
Conclusions
Antral branch of RGEV preservation may provide prevention from DGE for patients who undergo PPG.
Hatchery type influences the gill microbiome of Atlantic farmed salmon (Salmo salar) after transfer to sea
Authors: Katchkin-Stewart Kelly J , Boerlage Annette S. , Barr William , Ijaz Umer Z. , Smith Cindy J. 
Published: August 2024

Abstract

Background
Salmon aquaculture involves freshwater and seawater phases. Recently there has been an increase in multifactorial gill health challenges during the seawater phase which has led to an urgent need to understand the gill microbiome. There is a lack of understanding on what drives the composition of the gill microbiome, and the influence the freshwater stage has on its long-term composition. We characterise the gill microbiome from seven cohorts of Atlantic salmon raised in six different freshwater operational systems - recirculating aquaculture system (RAS), flowthrough (FT) and loch-based system, prior to and after transfer to seven seawater farms, over two different input seasons, S0 (2018) and S1 (2019).
Results
Using the V1-V2 region of the 16S rRNA gene, we produced amplicon libraries absent of host contamination. We show that hatchery system influenced the gill microbiome (PERMAOVA R2 = 0.226, P < 0.001). Loch and FT systems were more similar to each other than the three RAS systems, which clustered together. On transfer to sea, the gill microbiomes of all fish changed and became more similar irrespective of initial hatchery system, seawater farm location or season of input. Even though the gill microbiome among seawater farm locations was different between locations (PERMAOVA R2 = 0.528, P < 0.001), a clustering of the gill microbiomes by hatchery system of origin was still observed soon after transfer (PERMAOVA R = 0.164, P < 0.001). Core microbiomes were found between all salmon, hatcheries and seawater groups at a genus level, and at ASV level among FT and loch systems; and again among all seawater farms. The gill microbiome and surrounding water at each hatchery had more shared ASVs than seawater farms.
Conclusion
We show that hatchery system, loch, FT or RAS, significantly impacts the gill microbiome. On transfer to sea, the microbiomes change and become more similar. After transfer, the individual sites to which the fish are transferred become a significant driver, while a signature from the hatchery operation system remains. Future gill disease mitigation methods that target enhancing the gill microbiome may be most effective in the freshwater stage, as there were more shared ASVs between water and gill at hatchery, compared to at sea.
The Role of Chest X-ray in Tuberculosis Detection for High School Students in China: A Cross-sectional Study
Authors: Wang Mei , Yin Jin , Wu Chengguo , Shi Yaling , Liu Ying , Rao Jun , Li Dan , Su Qian , Zhang Zhengyu , Huang Xueyong , Yu Ya , Fan Jun , Wu Bo 
Published: August 2024

Abstract

Background
In China, pulmonary tuberculosis (PTB) screening for children and adolescents is not only focused on family contacts, but also students in high schools. The research objective is to investigate chest X-ray (CXR) abnormalities and its risk factors.
Methods
From January 2022 to December 2022, PTB screening was conducted among 24577 Senior 1 and Senior 2 students in Chongqing using the Tuberculin Skin Test (TST) and CXR.
Results
The detection rate for suspected PTB through CXR was 0.5% (95% Confidence Interval [CI], 0.3%-0.8%), and the detection rate for PTB through CXR was 0.4% (95% CI, 0.2%-0.6%). Participants in Southeast Districts were more likely to develop PTB (Adjusted Odds Ratio [AOR], 9.6; 95% CI, 1.3–70.4).
Conclusions
CXR has played a significant role in PTB screening in high schools in the Chongqing. It is necessary to strengthen policy support for the Southeast Districts in Chongqing.
Optic disc edema with decreased visual function after high-altitude exposure
Authors: Li Yuyu , Sun Mingming , Chen Biyue , Xu Xintong , Chen Xiyun , Wang Yuhang , Xu Quangang , Zhou Huanfen , Wei Shihui 
Published: August 2024

Abstract

Purpose
A high incidence of clinical optic disc edema in high altitudes has been shown; however, almost all patients completely regress on return to lowlands and do not complain of visual symptoms such as vision loss or visual field defect. Here, we report six patients with optic disc edema and remarkably decreased visual function after high-altitude exposure, which we diagnosis as nonarteritic anterior ischaemic optic neuropathy (NAION).
Methods
Clinical characteristics, intracranial pressure, and testing for risk factors associated with NAION were collected retrospectively from patients at the neuro-ophthalmology department of the People’s Liberation Army General Hospital in China presenting with optic disc edema and decreased visual function after high-altitude exposure between October 2020 and September 2023.
Results
Eleven eyes of six patients (five male and one female) were included, with a mean age of 47.3 ± 11.76 (range 28–63) years. Simultaneous bilateral eye involvement was present in 83.3% of (5/6) patients. All cases presented diffuse disc edema at the time of onset. There was a definite time lag, which ranged from 7 days to 1 month, between arrival at high altitude and onset of symptoms. All patients had normal intracranial pressure. Mean vision acuity was worst (20/50) at 2 weeks, and the best mean vision acuity was 20/30 at 6 months. Visual field defects were seen in all patients at the early stage of the disease and had eventual remnants. All patients had small cup-to-disc ratios. One patient had hypertension and severe sleep apnoea; one had hypercholesterolemia and hypertension; and one had hypercholesterolemia.
Conclusion
Optic disc edema with decreased visual function and visual field defects after high-altitude exposure can occur. The possibility of NAION should be considered in this situation.
Retrospective Cohort Study on 3D Printing Technology for Preoperative Rehearsal and Intraoperative Navigation in Laparoscopic Rectal Cancer Surgery with Left Colic Artery Preservation
Authors: Zhao Zongxian , Hu Zongju , Yao Rundong , Su Xinyu , Zhu Shu , Jie Sun , Yao Yuan 
Published: August 2024

Abstract

Background
Previous studies have shown that preserving the left colic artery (LCA) during laparoscopic radical resection for rectal cancer (RC) can maintain the blood supply to the remaining colon without compromising the oncological outcomes. However, anatomical variations in the branches of the inferior mesenteric artery (IMA) and LCA present significant surgical challenges. Here, we construct a 3D printing IMA model for preoperative rehearsal and intraoperative navigation to analyze its positive impact on surgical safety.
Methods
We retrospectively collected clinical dates from patients with RC who received laparoscopic radical resection from January 2022 to May 2024 at Fuyang City People's Hospital. Patients were divided into 3D printing group and control group and their perioperative characteristics were statistically analyzed.
Results
172 patients who underwent laparoscopic radical resection for RC were included in the study. Among them, a total of 32 patients were excluded due to exclusion criteria. Finally, observe group (3D printing group) was comprised of 72 patients, while control group consisted of 68 patients. Operating time (196.7 ± 44.5 vs. 233.3 ± 44.3 min, p < 0.001), intraoperative blood loss (43.9 ± 31.3 vs. 58.2 ± 30.8 ml, p = 0.005), duration of hospitalization (14.3 ± 5.1 vs. 18.7 ± 9.2 days, p < 0.001), and postoperative recovery time (9.1 ± 5.1 vs. 11.9 ± 7.1 days, p = 0.007) were significantly lower in observe group than in control group. There were no significant differences in the number of lymph node dissections, presence of lymph vessel invasion, postoperative intestinal obstruction and anastomotic leakage between the two groups.
Conclusions
Utilization of a 3D-printed IMA model in laparoscopic radical resection of RC can assist the surgeon in understanding the LCA anatomy preoperatively, reducing intraoperative bleeding, shortening operating time.
Groundwater geochemical modeling under severe climate conditions for sustainable agricultural development, the case of Chougafiya Basin, central Tunisia
Authors: Akrout Nourhene , Hajji Soumaya , Karoui Sedki , Choura Sirine , Hachicha Wafik , M. Aljuaid Awad , Chamkha Mohamed , Bouri Salem 
Published: August 2024

ABSTRACT

Monitoring groundwater quality (GWQ) is vital for water sustainability, mainly in arid to semi-arid regions with intense agriculture and inadequate irrigation management systems. It was, closely, linked to groundwater hydrochemistry (GWH). The present work aims to identify factors controlling this in the Chougafiya shallow aquifer (Central Tunisia), which is known for groundwater hypersalinization and intensive agricultural activities under severe climate conditions. Based on 30 inventoried wells data, the proposed approach combines (i) exploratory factor analysis and (ii) confirmatory factor analysis as a structural equation model (SEM) to detect the most relevant factors involved in GWH and their spatial variability. It has been demonstrated that GWH was governed by Na–Cl and Ca-SO4 type, resulting from evaporated minerals. The results showed a total explained variance of 86% and allowed the identification of two main factors that control groundwater salinization: (1) the natural factor, mainly, attributed to the water–rock interactions and (2) the anthropogenic factor, mainly related to anarchic farming practices. As a confirmatory analysis, the development of SEM led to the identification of the most important factors that control water mineralization. These results could be helpful for the strategic plans for water resources management in the studied area.
Sustainability framework for water infrastructure development in Nigeria: a modelling approach
Authors: Adeoti Oluwagbemi Samuel , Kandasamy Jaya , Vigneswaran Saravanamuthu 
Published: August 2024

ABSTRACT

This study introduces the Predictive Iterative Sustainability Model (PISM), a tailored framework designed to enhance water infrastructure sustainability evaluations in Nigeria. PISM addresses the lack of localised, adaptable frameworks by integrating three key components: a Viability Rating (VR), a Sustainability Rating (SR), and a conceptual formula within a predictive iterative process. This integrated approach optimises project evaluation and planning. Empirical data were derived by evaluating responses to a survey with 70 Likert-scale questions covering 265 sustainability challenges. This data was used to assess community viability for sustainable water infrastructure in five Nigerian communities facing significant water poverty. The results reveal VR scores ranging from 63.95 to 67.91%, establishing a benchmark for viability. SR scores, on the other hand, vary substantially from 179 to 424%, illustrating the model's capacity to evaluate sustainability under diverse conditions and identify critical, high-impact projects that can mitigate infrastructure failure risks. As a dynamic and adaptable framework, PISM holds significant potential to improve water infrastructure sustainability in Nigeria and similar regions globally.
Health Care Worker Usage of Large-Scale Health Information Exchanges in Japan: User-Level Audit Log Analysis Study
Authors: Suzumoto Jun , Mori Yukiko , Kuroda Tomohiro 
Published: August 2024

Abstract

Background
Over 200 health information exchanges (HIEs) are currently operational in Japan. The most common feature of HIEs is remote on-demand viewing or searching of aggregated patient health data from multiple institutions. However, the usage of this feature by individual users and institutions remains unknown.

Objective
This study aims to understand usage of the on-demand patient data viewing feature of large-scale HIEs by individual health care workers and institutions in Japan.

Methods
We conducted audit log analyses of large-scale HIEs. The research subjects were HIEs connected to over 100 institutions and with over 10,000 patients. Each health care worker’s profile and audit log data for HIEs were collected. We conducted four types of analyses on the extracted audit log. First, we calculated the ratio of the number of days of active HIE use for each hospital-affiliated doctor account. Second, we calculated cumulative monthly usage days of HIEs by each institution in financial year (FY) 2021/22. Third, we calculated each facility type’s monthly active institution ratio in FY2021/22. Fourth, we compared the monthly active institution ratio by medical institution for each HIE and the proportion of cumulative usage days by user type for each HIE.

Results
We identified 24 HIEs as candidates for data collection and we analyzed data from 7 HIEs. Among hospital doctors, 93.5% (7326/7833) had never used HIEs during the available period in FY2021/22, while 19 doctors used them at least 30% of days. The median (IQR) monthly active institution ratios were 0.482 (0.470‐0.487) for hospitals, 0.243 (0.230‐0.247) for medical clinics, and 0.030 (0.024‐0.048) for dental clinics. In 51.9% (1781/3434) of hospitals, the cumulative monthly usage days of HIEs was 0, while in 26.8% (921/3434) of hospitals, it was between 1 and 10, and in 3% (103/3434) of hospitals, it was 100 or more. The median (IQR) monthly active institution ratio in medical institutions was 0.511 (0.487‐0.529) for the most used HIE and 0.109 (0.0927‐0.117) for the least used. The proportion of cumulative usage days of HIE by user type was complex for each HIE, and no consistent trends could be discerned.

Conclusions
In the large-scale HIEs surveyed in this study, the overall usage of the on-demand patient data viewing feature was low, consistent with past official reports. User-level analyses of audit logs revealed large disparities in the number of days of HIE use among health care workers and institutions. There were also large disparities in HIE use by facility type or HIE; the percentage of cumulative HIE usage days by user type also differed by HIE. This study indicates the need for further research into why there are large disparities in demand for HIEs in Japan as well as the need to design comprehensive audit logs that can be matched with other official datasets.
Shaykh Ahmetjan Mustafi n. Social Elements of Islam and the Spirit of the Epoch
Authors: Zaripov I. A. 
Published: August 2024

This is a commented translation into Russian of the only publication of Ahmetjan Mustafi n (1902–1964) — the Muhtasib of the Spiritual Administration of Muslims of the European part of the USSR and Siberia (DUMES) for the Moscow and Gorky regions, the Chuvash and Mordovian ASSR, imam-khatib of the Moscow Cathedral Mosque in 1964–1986. The publication, published in Arabic in issue 3–4 of the magazine “Al-muslimūn fī ash-sharq as-sufi ā tiy” (“Muslims of the Soviet East”) for 1970, is a transcript of the author’s speech at the International Conference “For the Unity of Muslims in the Struggle for Peace, against Imperialist Aggression”, which took place in the same year in Tashkent. The speech is mainly an apologetics of the socialist system and the foreign policy of the USSR from the point of view of Islam in it’s modernist understanding, expressed both in direct reference to the sacred primary sources and through quoting the main representatives of this movement of the late XIX — early XX centuries — ‘Abdo, Afghani, Marjani and Bigiev.
Social and Political Activity of Muslim Women of Moscow in the Beginning of the 20th Century
Authors: Salakhetdinova D. R. 
Published: August 2024

The article focuses on the development of socio-political activities of Tatar women in Moscow at the beginning of the 20th century. This research seeks to illustrate to the academic community the status of Tatar women in early 20th-century society, and to contemplate the socio-political and public issues specifi cally faced by contemporary Tatar Muslim women and more broadly by the Muslim community in Russia. These activities became possible because, by the early 20th century, the Tatars had established the phenomena of women’s education and a female middle class. Among Muslims of Russia, these phenomena were predominantly observed among the Tatars. It was during this period that the legal, political, and social rights of Tatar women began to be consolidated as a comprehensive set of rights aimed at ensuring genuine gender equality.The novelty of this article is defi ned by the author’s attempt to analyze Muslim periodicals from the early 20th century to conduct a study on the activities of the Moscow Muslim women’s movement in protecting women’s rights, including political ones, as well as its participation in (including national) bodies and local self-governing bodies in April-May 1917.
PROFIT SHARING MECHANISM IN PRULINK SYARIAH INVESTOR ACCOUNT PRODUCT IN THE PERSPECTIVE OF MUDHARABAH MUSYTARAKAH CONTRACT
Authors: Mufdalifa Eva 
Published: August 2024

PRUlink Syariah Investor Account is one of the products launched by PT Prudential Insurance, which is a sharia insurance product with a single contribution combined between investment and insurance protection. PRUlink syari'ah is here to provide choices for the community in preparing for the future of his life and family. PRUlink syari'ah gives participants the option to choose what type of investment they want with each risk they have. Profit sharing of investment results is developed with a mudharabah musytarakah system. The insurance participants are the owners of capital (shahibul mal) and the sharia insurance company functions as a trustee (mudharib). The profit obtained from the development and it is divided between the participants and the company in accordance with the agreed provisions. This study aims to determine whether the application of mudharabah musytarakah at PT Prudential Insurance Sigli branch is in accordance with the principles contained in Islamic shariah. The results of this study are the application of the mudharabah musytarakah contract at PT Prudential Insurance Sigli branch is in accordance with the principles contained in Islamic shari'ah, the profits obtained will be put into the participant's pool of funds and then deducted by insurance costs. If there is an excess of funds remaining, it will be divided according to the principles of mudharabah musytarakah contract 70% of the profit for participants and 30% for the company. Profit sharing that is not in accordance with Islamic sharia principles is void.