bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marketing academics at the FTC: the inside story
Authors: Wilkie William L. , Murphy Patrick E. 
Published: January 2013

PurposeThe purpose of this article is to present an inside look at the history of a little‐known but interesting initiative in the marketing field, one that involved the infusion of marketing thought into public policy decision‐making in the USA. It aims to trace the interesting tale of how marketing academics came to be included in the activities of the US Federal Trade Commission (FTC) through the FTC's “Marketing Academic Consultancy Program” (MACP) during the 1970s. This story also aims to include descriptions of the contributions made by those marketing academics and how those scholars were later phased out of the FTC.Design/methodology/approachAn autobiographical approach is used since each of the authors was personally involved in the MACP. As participants in the program and as scholars whose careers were thereafter tremendously affected by that participation, these personal accounts provide considerable insight into the impact on both FTC operations and on marketing academic thought itself.FindingsOver the decade of the 1970s some 30 marketing academics participated in this program, with considerable impact on both FTC operations and on marketing academic thought itself. Reflecting positive impact within public policy, for example, was a massive increase in the FTC budget for marketing and consumer research activities – from essentially zero at the start of the program to some $ 1 million in 1978. Benefits also flowed back into academia, as this program formed a prime basis for the development of today's “Marketing and Society” research area.Originality/valueAlthough there are histories of the FTC, this is an original, first‐hand account of a little‐known era during which marketing academics and public policy decision‐makers were given a unique opportunity to work together and learn from each other. It offers personal insights into the workings of this innovative program and the benefits that accrued for both the FTC and for the marketing discipline.
Leishmaniaexpressed lipophosphoglycan interacts with Toll-like receptor (TLR)-2 to decrease TLR-9 expression and reduce anti-leishmanial responses
Authors: Srivastava S , Pandey S P , Jha M K , Chandel H S , Saha B 
Published: January 2013

SummaryTwo different Toll-like receptors (TLRs) have been shown to play a role in host responses to Leishmania infection. TLR-2 is involved in parasite survival in macrophages upon activation by lipophosphoglycan (LPG), a virulence factor expressed by Leishmania. In contrast, activation of TLR-9 has been shown to promote a host-protective response. However, whether there is a relationship between the interaction of LPG and TLR-2, on one hand, with the effect of TLR-9, on the other hand, remains unknown. In this study, we report that in-vitro infection of macrophages with a L. major parasite with high expression levels of LPG results in decreased TLR-9 expression compared to infection with a L. major parasite with lower expression levels of LPG. Addition of anti-LPG as well as anti-TLR-2 antibodies prevents this reduction of TLR-9 expression. Also, the addition of purified LPG to macrophages results in a decrease of TLR-9 expression, which is shown to be mediated by transforming growth factor (TGF)-β and interleukin (IL)-10. Finally, in-vitro treatment of macrophages with anti-LPG and/or anti-TLR-2 antibodies before infection reduces the number of amastigotes in macrophages and co-treatment of mice with anti-TLR-2 antibodies and cytosine–phosphate–guanosine (CpG) reduces footpad swelling and parasite load in the draining lymph nodes, accompanied by an interferon (IFN)-γ-predominant T cell response. Thus, for the first time, we show how interactions between LPG and TLR-2 reduce anti-leishmanial responses via cytokine-mediated decrease of TLR-9 expression.
Prospective, Multidimensional Evaluation of Sexual Disorders in Men After Laser Photovaporization of the Prostate
Authors: Terrasa Jean-Baptiste , Cornu Jean-Nicolas , Haab François , Cussenot Olivier , Lukacs Bertrand 
Published: January 2013

ABSTRACT

Introduction
A few studies have investigated the impact of photovaporization of the prostate (PVP) on sexual function and were mainly focused on erectile function.

Aims
To comprehensively evaluate the impact of PVP on sexual function.

Methods
A prospective evaluation involved sexually active patients needing surgical relief of bladder outlet obstruction due to benign prostatic enlargement in a single center between August 2007 and November 2011. All patients underwent PVP using the GreenLight HPS™ 120W system (AmericanMedicalSystems, Minnetonka, MN, USA).

Main Outcome Measures
Patients were evaluated preoperatively and postoperatively by International Prostate Symptom Score (I-PSS), I-PSS question 8, uroflowmetry parameters (maximum urinary flow rate [Qmax] and postvoid residual [PVR] volume), Danish Prostate Symptom Score Sexual items (DAN-PSSsex), and overall sexual satisfaction using a seven-grade Likert scale. Operative parameters and postoperative complications were also assessed. Preoperative and postoperative values were compared using the Pearson chi-square test and the Wilcoxon paired test. A multivariable model was used to investigate the determinants of variation of global sexual satisfaction.

Results
One hundred and two consecutive patients with 12-month follow-up data were included in the analysis. Urinary parameters (I-PSS, Qmax, and PVR) were significantly improved compared with preoperative values. Compared with baseline, postoperative erection symptom score was not significantly different, whereas ejaculation symptom score was significantly worse. Global DAN-PSSsex score was unchanged, but DAN-PSSsex symptom score was worse (P = 0.04) and DAN-PSSsex bother score was significantly improved (P &lt; 0.0001). Global sexual satisfaction was significantly improved compared with baseline (P = 0.02) and was significantly associated with I-PSS but not with erection and ejaculation score in a multivariable model.

Conclusion
Ejaculation is the main sexual function impacted by PVP. Despite this, sexual satisfaction and bother due to sexual symptoms were significantly improved, probably due to the positive impact of urinary symptom relief.
Salford alcohol assertive outreach team: a new model for reducing alcohol-related admissions
Authors: Hughes Neill R , Houghton Natalie , Nadeem Haitham , Bell Jackie , Mcdonald Suzanne , Glynn Noel , Scarfe Christopher , Mackay Bev , Rogers Anthony , Walters Melanie , Smith Martin , Mcdonald Andrew , Dalton David 
Published: January 2013

ObjectiveAlcohol-related admissions are increasing. A significant number of these admissions are attributable to a small number of complex patients with other comorbidities who do not engage well with mainstream services. Assertive outreach teams have been used in the field of psychiatry to engage patients who are poorly compliant. This study examines whether an alcohol assertive outreach team (AAOT) can engage with this group and reduce hospital admissions.DesignThe AAOT is a multidisciplinary team with medical, psychiatric, substance misuse, psychology, nursing and social work specialists. The team worked with patients with the highest number of alcohol-related admissions and case managed in a community setting for 6 months. The admission and emergency department attendances of the cohort were compared for the 3-month period before and after the intervention. Christo inventory for substance misuse services (CISS) scores were determined pre and post the intervention period.Results54 patients were case managed. The total number of admissions in 3 months fell from 151 prior to the intervention period to 50 following the intervention. Emergency department attendances also fell from 360 in 3 months to 146 following the intervention period. CISS scores fell from 11 preintervention to eight postintervention.ConclusionsAn AAOT model appears to reduce hospital admissions and emergency department attendances in a complex group of patients that display high alcohol-related admissions.
Long-term clinical effects of programmer-guided atrioventricular and interventricular delay optimization: Intracardiac electrography versus echocardiography for cardiac resynchronization therapy in patients with heart failure
Authors: Wang Dongmei , Yu Haibo , Yun Tian , Zang Hongyun , Yang Guitang , Wang Shouli , Wang Zulu , Jing Quanmin , Han Yaling 
Published: January 2013

Objectives To compare the haemodynamic results and long-term clinical outcomes of intracardiac electrography (QuickOpt®; St Jude Medical, St Paul, MN, USA) and echocardiography for optimization of atrioventricular (AV) and interventricular (VV) delays in cardiac resynchronization therapy (CRT). Methods Patients with CRT devices were prospectively enrolled; AV/VV delays were optimized by either QuickOpt® or echocardiography. Patients in the QuickOpt® group underwent both echocardiography and QuickOpt® optimization, and QuickOpt® AV/VV delays were used to program the CRT. All patients were followed-up for 12 months. Results In total, 44 patients were enrolled. There was good correlation between AV/VV delays determined by QuickOpt® ( n = 20) and echocardiography ( n = 24). QuickOpt® was significantly faster than echocardiography-guided optimization. Cardiac function, 6-min walking distance and left ventricular ejection fraction were significantly and similarly improved in both groups at 6 and 12 months compared with baseline. In the QuickOpt® group, left ventricular end diastolic diameters were significantly smaller at 6 and 12 months compared with baseline. Conclusions QuickOpt® is a quick, convenient and easy to perform method for optimization of AV and VV delays, with a similar long-term clinical outcome to echocardiography-guided optimization.
Downregulation of protocadherin-10 expression correlates with malignant behaviour and poor prognosis in human bladder cancer
Authors: Ma Jian-Guo , He Zheng-Kai , Ma Jian-Hua , Li Wen-Ping , Sun Guang 
Published: January 2013

Objectives This study retrospectively evaluated the prognostic significance of downregulated protocadherin-10 ( PCDH10) gene expression in bladder cancer. Methods To evaluate the prognostic significance of downregulated PCDH10 protein levels, immunohistochemistry was used to assess the level of PCDH10 protein in surgically-resected formalin-fixed, paraffin wax-embedded transitional cell carcinoma specimens. Relationships between PCDH10 protein levels, clinicopathological characteristics and overall survival were also evaluated. Results A total of 105 bladder transitional cell carcinoma specimens and 33 normal bladder epithelial samples were investigated using immunohistochemical staining. PCDH10 protein levels were downregulated in 63.8% (67/105) of bladder cancer specimens compared with control samples. Downregulated levels of PCDH10 were significantly associated with advanced stage, higher grade, larger tumour size, nonpapillary shape, tumour recurrence and decreased overall survival rates. Multivariate analysis indicated that downregulated PCDH10 levels were independently associated with decreased overall survival and had a relative risk of death of 4.571. Conclusions Downregulated PCDH10 levels correlated with malignant behaviour and poor overall survival in patients with bladder cancer. Downregulated PCDH10 levels might be useful as a prognostic biomarker for bladder cancer.
Un théologien à l’écoute de la musique
Authors: Charru Philippe 
Published: January 2013

Christoph Theobald travaille depuis de longues années en tant que théologien sur l’oeuvre de Jean-Sébastien Bach, en collaboration avec un musicien. On tente de faire entendre ici comment sa « manière de faire de la théologie », soucieuse de respecter l’autonomie des arts, le rend attentif à la réalité sensible des oeuvres musicales et à une conception génétique de leur forme où se profile « l’opération même du style », selon le mot de Merleau-Ponty. On montre comment l’émergence de cette notion du style dans le champ esthétique, l’a conduit à « penser le mystère chrétien comme “style en relation avec d’autres styles” impliquant un rapport absolument spécifique au beau ».
Synthesis, Photochromic, and Computational Studies of Dithienylethene‐Containing β‐Diketonate Derivatives and Their Near‐Infrared Photochromic Behavior Upon Coordination of a Boron(III) Center
Authors: Poon Chun‐Ting , Lam Wai Han , Yam Vivian Wing‐Wah 
Published: January 2013

AbstractA series of dithienylethene‐containing 1‐thienyl‐3‐aryl‐propane‐1,3‐diones (aryl=phenyl (Ph), thienyl (Th), and 4,5‐bis(2,5‐dimethylthiophen‐3‐yl)thiophen‐2‐yl (DTE‐Th)) and the corresponding boron(III) diketonates, (O^O)BR2 (R=F, C6F5, and Ph), have been designed and synthesized. Their photophysical, electrochemical, and photochromic properties have been studied. Upon coordination of a boron(III) center, the closed forms of the dithienylethene‐containing β‐diketonates show near‐infrared response and the photochromic behavior was also found to be affected by the aryl substituents at the 3‐position of the β‐diketonates. Moreover, computational studies have been performed that help to provide an understanding of the effect of substituents on the photophysical and photochromic properties.
Highly Selective Sorption and Luminescent Sensing of Small Molecules Demonstrated in a Multifunctional Lanthanide Microporous Metal–Organic Framework Containing 1D Honeycomb‐Type Channels
Authors: Li Huanhuan , Shi Wei , Zhao Kaina , Niu Zheng , Li Huimin , Cheng Peng 
Published: January 2013

AbstractA rare, robust microporous lanthanide metal–organic framework with 1D honeycomb‐type channels is presented. Excellent adsorption capabilities for N2, H2, and CO2 and significant selective sorption of CO2 over N2 and CH4 were observed. Moreover, the guest‐dependent luminescent behavior of these lanthanide materials shows a potential use for the sensing of small‐molecule pollutants such as benzene and acetone.
White matter fractional anisotropy is inversely related to anxious symptoms in older adults with atherosclerosis
Authors: Bijanki Kelly R. , Stillman Ashley N. , Arndt Stephan , Magnotta Vincent A. , Fiedorowicz Jess G. , Haynes William G. , Matsui Joy T. , Johnson Hans J. , Moser David J. 
Published: January 2013

ObjectiveClinical anxiety disorders are associated with white matter hyperintensities and diffusion abnormalities measured using diffusion tensor imaging. However, it is not known if this association extends into individuals with mild anxious symptoms without formal diagnosis, in those who are older, or in those who have atherosclerosis. The current study explores whether white matter integrity and/or organization significantly associates with anxious symptoms in older adults with and without atherosclerosis.MethodsWe recruited older adults (ages 55–90 years); 35 with clinically diagnosed atherosclerotic vascular disease (AVD) and 22 without AVD. Anxious symptoms were measured using the validated Symptom Checklist‐90‐Revised. Fractional anisotropy (FA), a proxy for white matter organization and health, was measured in the white matter globally, by lobe, and in several smaller regions of interest suggested by the literature. Partial correlations between anxious symptoms and FA were calculated, controlling for significant covariates.ResultsParticipants with and without AVD did not differ in severity of anxious symptom endorsement. There was a unique inverse relationship between white matter health and anxious symptoms in the AVD participants, but not in healthy comparisons. Significant relationships were observed in the superior longitudinal fasciculus (r = −0.476, df = 32, p = 0.004), as well as the cingulum bundle, the frontal lobes, and the parietal lobes.ConclusionsAnxiety symptoms uniquely correlated with low FA in older adults with atherosclerosis. These findings may have implications for future research on the topic of anxiety in aging and vascular disease and warrant replication. Copyright © 2013 John Wiley & Sons, Ltd.
Community pharmacists and people with dementia: a cross‐sectional survey exploring experiences, attitudes, and knowledge of pain and its management
Authors: Barry Heather E. , Parsons Carole , Passmore A. Peter , Hughes Carmel M. 
Published: January 2013

ABSTRACTObjectivesTo explore community pharmacists' experiences with and attitudes towards people with dementia, and to determine the knowledge they have about pain and its management in this patient population.MethodsA questionnaire comprising five sections, including the Approaches to Dementia Questionnaire, was mailed, on two occasions, during February and March 2011, to all community pharmacies in Northern Ireland (n = 530).ResultsThe response rate was 34.3%. A greater proportion of pharmacists provided pharmaceutical care to people with dementia living at home (91.2%) than those living in care homes (40.1%). Respondents most frequently encountered queries relating to starting and stopping medications, compliance with medication, and availability of formulation types. The mean total score for the Approaches to Dementia Questionnaire measure was 72.8, indicating a positive attitude towards people with dementia, and respondents demonstrated a strong person‐centred approach towards this patient population. The majority of respondents recognised the difficulty of assessing pain in people with dementia; however, younger pharmacists (p = 0.041) and pharmacists who provided pharmaceutical care to people with dementia (p = 0.012) were more likely to be aware of the pain assessment tools for use in people with dementia. Pharmacists appeared uncertain about how to appropriately manage pain in people with dementia.ConclusionsThe study has revealed that community pharmacists often encounter people with dementia, especially those living in their own homes, and they have positive attitudes towards the patient population. However, training in the assessment and management of pain in people with dementia must be developed to further improve their knowledge in this area. Copyright © 2013 John Wiley & Sons, Ltd.
Synthesis of New Thienopyridine Derivatives by a Reaction of 4‐(Methylsulfanyl)‐6,7‐dihydrothieno[3,2‐c]pyridine with Amino Acids
Authors: Milen Mátyás , Ábrányi‐Balogh Péter , Dancsó András , Drahos László , Keglevich György 
Published: January 2013

ABSTRACTNew thienopyridine derivatives were synthesized by the reaction of 4‐(methylsulfanyl)‐6,7‐dihydrothieno[3,2‐c]pyridine (5) with amino acids. The use of β‐amino acids led to thienopyridopyrimidone derivatives (9a–g). Using α‐amino acids, such as glycine and racemic alanine under the same reaction conditions, compounds with two thienopyridine units were obtained. The structure of the novel compounds was confirmed by IR, 13C, and 1H NMR spectroscopy, as well as mass spectrometry, along with single crystal X‐ray analysis. © 2013 Wiley Periodicals, Inc. Heteroatom Chem 24:124–130, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21073
Pesticides, Microglial NOX2, and Parkinson's Disease
Authors: Taetzsch Thomas , Block Michelle L. 
Published: January 2013

ABSTRACTAccumulating evidence indicates that pesticide exposure is associated with an increased risk for developing Parkinson's disease (PD). Several pesticides known to damage dopaminergic (DA) neurons, such as paraquat, rotenone, lindane, and dieldrin also demonstrate the ability to activate microglia, the resident innate immune cell in the brain. While each of these environmental toxicants may impact microglia through unique mechanisms, they all appear to converge on a common final pathway of microglial activation: NADPH oxidase 2 (NOX2) activation. This review will detail the role of microglia in selective DA neurotoxicity, highlight what is currently known about the mechanism of microglial NOX2 activation in these key pesticides, and describe the importance for DA neuron survival and PD etiology. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:137‐149, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21464
The role of networks in science communication and engagement with non‐expert publics
Authors: Finn Jeanine 
Published: January 2013

AbstractIn this ongoing study, I examine associations among scientists by analyzing scholarly publication data and Internet hyperlink relationships using a social network analysis framework. Unlike other studies of collaboration, this study does not start with an extant network of scientists who share a research focus, but rather groups who are networked for purposes of public and political engagement. I have chosen as my nodes two presumed “networks” of scientists: the group of 16 scientists who authored a January 27th', 2012 op‐ed inThe Wall Street Journalwhich suggested concerns about climate change were being exaggerated, and the group of 38 scientists who authored a response piece (supporting climate change science) on February 1st.I have chosen climate science because of its scientific complexity that is of necessity interdisciplinary, and its scrutiny by non‐expert publics. Building on the theoretical foundations of social epistemology, I examine how notions of the role of shared practices in engendering trust and knowledge‐sharing among expert groups can be applied when the lines between expert and non‐expert are contested in high‐visibility public arenas. In exploring some of those questions, this study aims to discover if a social network methodology combining co‐authorship data and hyperlink data can reveal patterns of association and engagement with traditional (e.g., scholarly publications) vs. non‐traditional (e.g., web sites or blog articles) methods of communication and legitimation.This study is intended as part of a larger research trajectory examining the role of social associations in influencing credibility and information trust decisions in areas where expert and non‐experts must meet and negotiate shared meanings. These findings could suggest future directions for collaborative data sharing practices as well as support theoretical work in understanding how trust and credibility are granted in networked information environments.
Growth mechanisms of co‐evaporated kesterite: a comparison of Cu‐rich and Zn‐rich composition paths
Authors: Hsu Wan‐Ching , Repins Ingrid , Beall Carolyn , DeHart Clay , To Bobby , Yang Wenbing , Yang Yang , Noufi Rommel 
Published: January 2013

ABSTRACTEarth abundant kesterite solar cells have achieved 7–10% cell efficiency mostly by processes that separate the film deposition and the annealing into two sequential steps. In contrast, co‐evaporation onto a high‐temperature substrate, demonstrating previous success in chalcopyrite (Cu(In,Ga)Se2) solar cells, allows real‐time composition control. Chalcopyrite research widely supports the model that Cu‐rich growth conditions assist grain growth, and subsequently, the endpoint composition can be adjusted back to Cu‐poor via monitoring the surface emissivity of the film. On the basis of the same intentions, the recent development of co‐evaporated kesterite (Cu2ZnSnSe4) adapts the concept and achieves 9.2% efficiency. To understand the effect of growth strategies, this study examines the phase evolution, grain morphology, and device performance in Cu‐rich growth and other strategies (Zn‐rich and close‐to‐stoichiometric). By characterizing films obtained from interrupted depositions and also interpreting the variation in surface emission during growths, this study found a subtle hindrance in the reaction of CuxSey and ZnSe possibly caused by the volatile nature of SnSex. The hindrance explains why, distinctive from chalcopyrite, little difference in grain size is observed between kesterite films made by Cu‐rich versus Zn‐rich growth at these deposition rates. At last, a Zn‐rich growth 9.1% device, certified by the National Renewable Energy Laboratory, is presented, which equals the performance of the previously‐reported Cu‐rich growth device. At the present stage, we believe the Cu‐rich and Zn‐rich growth share equal promise for the optimization of kesterite solar cells. Copyright © 2013 John Wiley & Sons, Ltd.