bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fastbreak: a tool for analysis and visualization of structural variations in genomic data
Authors: Bressler Ryan , Lin Jake , Eakin Andrea , Robinson Thomas , Kreisberg Richard , Rovira Hector , Knijnenburg Theo , Boyle John , Shmulevich Ilya 
Published: October 2012

Abstract
Genomic studies are now being undertaken on thousands of samples requiring new computational tools that can rapidly analyze data to identify clinically important features. Inferring structural variations in cancer genomes from mate-paired reads is a combinatorially difficult problem. We introduce Fastbreak, a fast and scalable toolkit that enables the analysis and visualization of large amounts of data from projects such as The Cancer Genome Atlas.
Craniofacial reconstruction based on a hierarchical dense deformable model
Authors: Hu Yongli , Duan Fuqing , Zhou Mingquan , Sun Yanfeng , Yin Baocai 
Published: October 2012

AbstractCraniofacial reconstruction from skull has deeply been investigated by computer scientists in the past two decades because it is important for identification. The dominant methods construct facial surface from the soft tissue thickness measured at a set of skull landmarks. The quantity and position of the landmarks are very vital for craniofacial reconstruction, but there is no standard. In addition, it is difficult to accurately locate the landmarks on dense mesh without manual assistance. In this article, we propose an automatic craniofacial reconstruction method based on a hierarchical dense deformable model. To construct the model, we collect more than 100 head samples by computerized tomography scanner. The samples are represented as dense triangle mesh to model face and skull shape. As the deformable model demands all samples in uniform form, a non-rigid registration algorithm is presented to align the samples in point-to-point correspondence. Based on the aligned samples, a global deformable model is constructed, and three local models are constructed from the segmented patches of the eye, nose, and mouth. For a given skull, the global and local deformable models are matched with it, and the reconstructed facial surface is obtained by fusing the global and local reconstruction results. To validate our method, a face deformable model is constructed and the reconstruction results are evaluated in its coefficient domain. The experimental results indicate that the proposed method has good performance for craniofacial reconstruction.
Interactive wiimote gaze stabilization exercise training system for patients with vestibular hypofunction
Authors: Chen Po-Yin , Hsieh Wan-Ling , Wei Shun-Hwa , Kao Chung-Lan 
Published: October 2012

AbstractBackgroundPeripheral vestibular hypofunction is a major cause of dizziness. When complicated with postural imbalance, this condition can lead to an increased incidence of falls. In traditional clinical practice, gaze stabilization exercise is commonly used to rehabilitate patients. In this study, we established a computer-aided vestibular rehabilitation system by coupling infrared LEDs to an infrared receiver. This system enabled the subjects’ head-turning actions to be quantified, and the training was performed using vestibular exercise combined with computer games and interactive video games that simulate daily life activities.MethodsThree unilateral and one bilateral vestibular hypofunction patients volunteered to participate in this study. The participants received 30 minutes of computer-aided vestibular rehabilitation training 2 days per week for 6 weeks. Pre-training and post-training assessments were completed, and a follow-up assessment was completed 1 month after the end of the training period.ResultsAfter 6 weeks of training, significant improvements in balance and dynamic visual acuity (DVA) were observed in the four participants. Self-reports of dizziness, anxiety and depressed mood all decreased significantly. Significant improvements in self-confidence and physical performance were also observed. The effectiveness of this training was maintained for at least 1 month after the end of the training period.ConclusionReal-time monitoring of training performance can be achieved using this rehabilitation platform. Patients demonstrated a reduction in dizziness symptoms after 6 weeks of training with this short-term interactive game approach. This treatment paradigm also improved the patients’ balance function. This system could provide a convenient, safe and affordable treatment option for clinical practitioners.
Ethno-botanical study of the African star apple (Chrysophyllum albidum G. Don) in the Southern Benin (West Africa)
Authors: Houessou Laurent G , Lougbegnon Toussaint O , Gbesso François GH , Anagonou Lisette ES , Sinsin Brice 
Published: October 2012

Abstract
Background
In addition to plant species biology and ecology, understanding the folk knowledge systems related to the use of plant species and how this knowledge system influences the conservation of plant species is an important issue in the implementation of sustainable strategies of biodiversity conservation programs. This study aimed at providing information on the use and local knowledge variation on Chrysophyllum albidum G. Don a multipurpose tree species widely used in southern Benin.

Methods
Data was collected through 210 structured interviews. Informants were randomly selected from ten villages. The fidelity level and use value of different plant parts of C. albidum were estimated. The variation in ethnobotanical knowledge was assessed by comparing the use value between ethnic, gender and age groups. In order to assess the use pattern of the different plant parts in folk medicine, a correspondence analysis was carried out on the frequency citation of plant parts.

Results
Four categories of use (food, medicine, firewood and timber) were recorded for C. albidum. With respect to the different plant parts, the fleshy pulp of the African star apple fruit showed high consensus degree as food among the informants. Fifteen diseases were reported to be treated by the different parts of C. albidum in the region. Correspondence analysis revealed the specificity of each part in disease treatment. There was no significant difference among ethnic groups regarding the ethno-botanical use value of C. albidum. However, significant difference existed between genders and among age groups regarding the knowledge of the medical properties of this species.

Conclusions
C. albidum is well integrated in the traditional agroforestry system of the southern Benin. Despite its multipurpose character, this species remains underutilized in the region. Considering the current threat of habitat degradation, action is needed in order to ensure the long term survival of the species and local communities’ livelihoods.
Completion pneumonectomy for lung cancer treatment: early and long term outcomes
Authors: Zhang Peng , Jiang Chao , He Wenxin , Song Nan , Zhou Xiao , Jiang Gening 
Published: October 2012

Abstract

Background
To analyze the experience of completion pneumonectomy for lung cancer at a single institution in China.

Methods
From January 1988 to December 2007, 92 patients underwent completion pneumonectomy for the treatment of lung cancer. The indications were second primary lung cancer (n = 51), Local metastasis (n = 37) and Lung metastasis (n = 4). The median interval between the primary operation and CP was 24.4 months (1.5-145 m).

Results
There was no intraoperative deaths. The CP procedure lasted 4.3 h (1.5-8 h). Blood loss in the CP performance was 1854.5 ml (200-9100 ml) 9 (9.78%) patients died in the postoperative period: pulmonary embolism (n = 2), disseminated intravascular coagulation (DIC) after the multisystem failure (n = 1), respiratory failure after contralateral pneumonia (n = 5), bronchopleural fistula (BPF) with acute respiratory distress syndrome (ARDS) (n = 1) 31(33.7%) patients had at least one major nonfatal complication. The 1, 3 and 5 year survival rates were 81%, 26% and 14% respectively.

Conclusions
Completion pneumonectomy for lung cancer is a safe surgical procedure for the skilled surgeon though it has a relatively higher complications and the long-term survival is acceptable.
A review on delayed toxic effects of sulfur mustard in Iranian veterans
Authors: mansour Razavi Seyed , Salamati Payman , Saghafinia Masoud , Abdollahi Mohammad 
Published: October 2012

Abstract
Iranian soldiers were attacked with chemical bombs, rockets and artillery shells 387 times during the 8-years war by Iraq (1980–1988). More than 1,000 tons of sulfur mustard gas was used in the battlefields by the Iraqis against Iranian people. A high rate of morbidities occurred as the result of these attacks. This study aimed to evaluate the delayed toxic effects of sulfur mustard gas on Iranian victims. During a systematic search, a total of 193 (109 more relevant to the main aim) articles on sulfur mustard gas were reviewed using known international and national databases. No special evaluation was conducted on the quality of the articles and their publication in accredited journals was considered sufficient. High rate of morbidities as the result of chemical attacks by sulfur mustard among Iranian people occurred. Iranian researchers found a numerous late complications among the victims which we be listed as wide range of respiratory, ocular, dermatological, psychological, hematological, immunological, gastrointestinal and endocrine complications, all influenced the quality of life of exposed victims. The mortality rate due to this agent was 3%. Although, mortality rate induced by sulfur mustard among Iranian people was low, variety and chronicity of toxic effects and complications of this chemical agent were dramatic.
Structural defects in cilia of the choroid plexus, subfornical organ and ventricular ependyma are associated with ventriculomegaly
Authors: Swiderski Ruth E , Agassandian Khristofor , Ross Jean L , Bugge Kevin , Cassell Martin D , Yeaman Charles 
Published: October 2012

Abstract

Background
Hydrocephalus is a heterogeneous disorder with multiple etiologies that are not yet fully understood. Animal models have implicated dysfunctional cilia of the ependyma and choroid plexus in the development of the disorder. In this report, we sought to determine the origin of the ventriculomegaly in four Bardet Biedl syndrome (BBS) mutant mouse strains as models of a ciliopathy.

Methods
Evans Blue dye was injected into the lateral ventricle of wild- type and BBS mutant mice to determine whether obstruction of intra- or extra-ventricular CSF flow contributed to ventriculomegaly. Transmission electron microscopy (TEM) was used to examine the ultrastructure of the choroid plexus, subfornical organ (SFO), subcommisural organ (SCO), and ventricular ependyma to evaluate their ultrastructure and the morphology of their primary and motile cilia.

Results and discussion
No obstruction of intra- or extra-ventricular CSF flow was observed, implying a communicating form of hydrocephalus in BBS mutant mice. TEM analyses of the mutants showed no evidence of choroidal papillomas or breakdown of the blood:CSF barrier. In contrast, structural defects were observed in a subpopulation of cilia lining the choroid plexus, SFO, and ventricular ependyma. These included disruptions of the microtubular structure of the axoneme and the presence of electron-dense vesicular-like material along the ciliary shaft and at the tips of cilia.

Conclusions
Abnormalities in cilia structure and function have the potential to influence ciliary intraflagellar transport (IFT), cilia maintenance, protein trafficking, and regulation of CSF production. Ciliary structural defects are the only consistent pathological features associated with CSF-related structures in BBS mutant mice. These defects are observed from an early age, and may contribute to the underlying pathophysiology of ventriculomegaly.
Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier
Authors: Chiang Huai-Chin , Nair Sreejith J , Yeh I-Tien , Santillan Alfredo A , Hu Yanfen , Elledge Richard , Li Rong 
Published: October 2012

Abstract
Radiation therapy (RT) after breast conservation therapy has recently been linked with significant reduction in risk of ipsilateral breast cancer among BRCA1 mutation carriers. However, the exact mechanism by which RT reduces incidence of BRCA1-associated cancer remains unclear. Here we studied fresh breast tissue from a BRCA1 mutation carrier who was initially treated with a lumpectomy and RT for a unilateral cancer and two years later chose a prophylactic bilateral mastectomy while remaining cancer-free. Flow cytometry analysis demonstrated a strikingly lower luminal cell population in the irradiated breast as compared to the non-irradiated breast, which was confirmed by immunohistochemistry. Furthermore, the irradiated breast tissue exhibited very low progenitor cell activity in vitro. Given the emerging evidence that BRCA1 tumors originate from luminal progenitor cells, our observations suggest that preferential and long-lasting elimination of luminal ductal epithelium may partly underlie the mechanism of RT-associated reduction in recurrence of BRCA1-associated cancer.
Tall or taller, pretty or prettier: is discrimination absolute or relative?
Authors: Hamermesh Daniel S 
Published: October 2012

Abstract
Using microeconomic data sets from the United States and the Netherlands, this study considers how agents perceive characteristics that are discriminated against. It uses the examples of beauty and height to examine whether: 1) Absolute or relative differences in a characteristic affect labor-market and other outcomes; and 2) The effects of a characteristic change when all agents acquire more of it. Decision-makers seem to respond more to absolute than to relative differences among individuals. Weaker results show that an increase in the mean of a characteristic’s distribution does not alter market responses to differences in it.
Personality and marital surplus
Authors: Lundberg Shelly 
Published: October 2012

AbstractThis paper uses data from the German Socio-economic Panel Study to examine the effect of personality traits on the formation and dissolution of domestic partnerships. Selection into marriage is associated with distinctly different personality profiles for men and women born before 1960, suggesting that gender-specialized contributions to household public goods were an important source of marital surplus for these cohorts. The effects of personality on marriage are more similar for younger men and women; this is consistent with marital returns based on joint consumption. Divorce is associated with low expected marital surplus, low emotional stability for women, and male extroversion.
Another economic miracle? The German labor market and the Great Recession
Authors: Rinne Ulf , Zimmermann Klaus F 
Published: October 2012

Abstract
Germany’s labor market responded only mildly to the Great Recession. Important factors for this development include the strong economic position due to recent labor market reforms, the crisis affecting mainly export-oriented companies, the extension of short-time work, time buffers due to working time accounts, the behavior of social partners, and automatic stabilizers. We emphasize the important interaction between short-time work and long-term shortages of skilled workers in sectors particularly affected by the crisis. Although Germany’s experience is in stark contrast to the United States, we identify and discuss common challenges at the center of the future jobs debate.
Human capital transmission and the earnings of second-generation immigrants in Sweden
Authors: Hammarstedt Mats , Palme Mårten 
Published: October 2012

Abstract
We compare the earnings and the intergenerational earnings mobility of immigrants with natives in Sweden. We find an overall convergence in average earnings between immigrants and natives across generations. This convergence hides a divergence in average earnings between groups of immigrants with different ethnic origins. We also find that, on average, immigrants have lower intergenerational earnings mobility within groups with similar ethnic backgrounds. Immigrant groups with relatively low intergenerational earnings mobility increased their average relative earnings in the second generation. The interpretation of this is that immigrant groups with a high degree of intergenerational transmission of human capital from parent to offspring improve their position on the labor market across generations.
Microhardness of bi-antibiotic-eluting bone cement scaffolds
Authors: Musib Mrinal , Jones Jeremy , Chakote Karunesh , Hayes Westley , Saha Subrata 
Published: October 2012

Abstract
Bi-antibiotic-impregnated bone cements (BIBCs) are widely used in orthopaedics as a prophylactic agent (depot) to address post-surgical infections. Although hardness is widely considered a viable index to measure the integrity of the cement structure, there are few specific studies involving changes in hardness characteristics of BIBCs post elution of high doses of two widely used antibiotics: tobramycin and gentamicin. Increased doses of antibiotics and increased duration of elution may also decrease the hardness of polymethyl methacrylate (PMMA) bone cement, thus increasing the chances of shattering, scratching, and deformation.
In this project, we have investigated the changes in surface hardness of five different antibiotic-loaded specimens: 0.5 g tobramycin and 0.5 g gentamicin together, 1 g tobramycin, 1 g gentamicin, 5 g tobramycin and 5 g gentamicin together, and 10 g tobramycin (each added to 40 g of PMMA), post elution for various time periods (1, 3, and 21 days). The effect of hydration on the hardness of bone cement was studied to replicate in vivo conditions. The micro-indentation tester (Buehler m5103) was utilized to determine if the increased antibiotic loads would compromise the integrity of the bone cement matrix.
The results demonstrated that the amount of drug initially incorporated determined the hardness of the cement post elution. As compared to the control (no antibiotic), specimens containing 1 and 10 g of antibiotic exhibited over 50% and 73% decrease in hardness, respectively. The different treatment durations (post 1 day) as well as the hydration conditions had insignificant effect on the hardness of the cement.
Validation of a Gene Expression Signature for Assessment of Lymph Node Metastasis in Oral Squamous Cell Carcinoma
Authors: van Hooff Sander R. , Leusink Frank K.J. , Roepman Paul , Baatenburg de Jong Robert J. , Speel Ernst-Jan M. , van den Brekel Michiel W.M. , van Velthuysen Marie-Louise F. , van Diest Paul J. , van Es Robert J.J. , Merkx Matthias A.W. , Kummer J. Alain , Leemans C. René , Schuuring Ed , Langendijk Johannes A. , Lacko Martin , De Herdt Maria J. , Jansen Jeroen C. , Brakenhoff Ruud H. , Slootweg Piet J. , Takes Robert P. , Holstege Frank C.P. 
Published: October 2012

Purpose Current assessment of lymph node metastasis in patients with head and neck squamous cell carcinoma is not accurate enough to prevent overtreatment. The aim of this study was validation of a gene expression signature for distinguishing metastasizing (N+) from nonmetastasizing (N0) squamous cell carcinoma of the oral cavity (OSCC) and oropharynx (OPSCC) in a large multicenter cohort, using a diagnostic DNA microarray in a Clinical Laboratory Improvement Amendments/International Organization for Standardization–approved laboratory. Methods A multigene signature, previously reported as predictive for the presence of lymph node metastases in OSCC and OPSCC, was first re-evaluated and trained on 94 samples using generic, whole-genome, DNA microarrays. Signature genes were then transferred to a dedicated diagnostic microarray using the same technology platform. Additional samples (n = 222) were collected from all head and neck oncologic centers in the Netherlands and analyzed with the diagnostic microarray. Human papillomavirus status was determined by real-time quantitative polymerase chain reaction. Results The negative predictive value (NPV) of the diagnostic signature on the entire validation cohort (n = 222) was 72%. The signature performed well on the most relevant subset of early-stage (cT1-T2N0) OSCC (n = 101), with an NPV of 89%. Conclusion Combining current clinical assessment with the expression signature would decrease the rate of undetected nodal metastases from 28% to 11% in early-stage OSCC. This should be sufficient to enable clinicians to refrain from elective neck treatment. A new clinical decision model that incorporates the expression signature is therefore proposed for testing in a prospective study, which could substantially improve treatment for this group of patients.
Obesity and Risk of Recurrence or Death After Adjuvant Endocrine Therapy With Letrozole or Tamoxifen in the Breast International Group 1-98 Trial
Authors: Ewertz Marianne , Gray Kathryn P. , Regan Meredith M. , Ejlertsen Bent , Price Karen N. , Thürlimann Beat , Bonnefoi Hervé , Forbes John F. , Paridaens Robert J. , Rabaglio Manuela , Gelber Richard D. , Colleoni Marco , Láng István , Smith Ian E. , Coates Alan S. , Goldhirsch Aron , Mouridsen Henning T. 
Published: October 2012

PurposeTo examine the association of baseline body mass index (BMI) with the risk of recurrence or death in postmenopausal women with early-stage breast cancer receiving adjuvant tamoxifen or letrozole in the Breast International Group (BIG) 1-98 trial at 8.7 years of median follow-up.Patients and MethodsThis report analyzes 4,760 patients with breast cancer randomly assigned to 5 years of monotherapy with letrozole or tamoxifen in the BIG 1-98 trial with available information on BMI at randomization. Multivariable Cox modeling assessed the association of BMI with disease-free survival, overall survival (OS), breast cancer–free interval, and distant recurrence-free interval and tested for treatment-by-BMI interaction. Median follow-up was 8.7 years.ResultsSeventeen percent of patients have died. Obese patients (BMI ≥ 30 kg/m2) had slightly poorer OS (hazard ratio [HR] = 1.19; 95% CI, 0.99 to 1.44) than patients with normal BMI (< 25 kg/m2), whereas no trend in OS was observed in overweight (BMI 25 to < 30 kg/m2) versus normal-weight patients (HR = 1.02; 95% CI, 0.86 to 1.20). Treatment-by-BMI interactions were not statistically significant. The HRs for OS comparing obese versus normal BMI were HR = 1.22 (95% CI, 0.93 to 1.60) and HR = 1.18 (95% CI, 0.91 to 1.52) in the letrozole and tamoxifen groups, respectively.ConclusionThere was no evidence that the benefit of letrozole over tamoxifen differed according to patients' BMI.