bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic networks reveal key players in aging
Authors: Faisal Fazle E. , Milenković Tijana 
Published: February 2014

Motivation: Because susceptibility to diseases increases with age, studying aging gains importance. Analyses of gene expression or sequence data, which have been indispensable for investigating aging, have been limited to studying genes and their protein products in isolation, ignoring their connectivities. However, proteins function by interacting with other proteins, and this is exactly what biological networks (BNs) model. Thus, analyzing the proteins’ BN topologies could contribute to the understanding of aging. Current methods for analyzing systems-level BNs deal with their static representations, even though cells are dynamic. For this reason, and because different data types can give complementary biological insights, we integrate current static BNs with aging-related gene expression data to construct dynamic age-specific BNs. Then, we apply sensitive measures of topology to the dynamic BNs to study cellular changes with age.Results: While global BN topologies do not significantly change with age, local topologies of a number of genes do. We predict such genes to be aging-related. We demonstrate credibility of our predictions by (i) observing significant overlap between our predicted aging-related genes and ‘ground truth’ aging-related genes; (ii) observing significant overlap between functions and diseases that are enriched in our aging-related predictions and those that are enriched in ‘ground truth’ aging-related data; (iii) providing evidence that diseases which are enriched in our aging-related predictions are linked to human aging; and (iv) validating our high-scoring novel predictions in the literature.Availability and implementation: Software executables are available upon request.Contact: tmilenko@nd.eduSupplementary information: Supplementary Data are available at Bioinformatics online.
Functional normalization of 450k methylation array data improves replication in large cancer studies
Authors: Fortin Jean-Philippe , Labbe Aurélie , Lemire Mathieu , Zanke Brent W. , Hudson Thomas J. , Fertig Elana J. , Greenwood Celia M.T. , Hansen Kasper D. 
Published: February 2014

AbstractWe propose an extension to quantile normalization which removes unwanted technical variation using control probes. We adapt our algorithm, functional normalization, to the Illumina 450k methylation array and address the open problem of normalizing methylation data with global epigenetic changes, such as human cancers. Using datasets from The Cancer Genome Atlas and a large case-control study, we show that our algorithm outperforms all existing normalization methods with respect to replication of results between experiments, and yields robust results even in the presence of batch effects. Functional normalization can be applied to any microarray platform, provided suitable control probes are available.
Networks in knowledge-intensive industry: the case of a regional accountants' network
Authors: Nandan Ruvendra , Ciccotosto Susan 
Published: February 2014

Purpose
– The paper aims to explore the reasons behind the formation of a regional accountants' network located in North Queensland, Australia, and examine in depth how relationships are constituted and maintained between the network members. The study also looks at the benefits arising from the network, structural constraints and the reasons behind its demise.

Design/methodology/approach
– This study adopts a more contemporary theoretical perspective which draws upon the notion of social capital that facilitates networks' capacity and capabilities for creating, sharing and accessing knowledge. This field study considers the specific case of the Cairns Regional Accountants' Forum (CRAF), a network of small and medium sized public accounting firms located far away from the metropolitan centres in Australia. Apart from the relevant archival data, senior partners/principals of 12 accounting firms were interviewed in a semi-structured manner. Three further interviews were held with the non-active members of the CRAF and telephone calls were made to the Regional Tax Practitioner Forum to discuss their involvement with the local accountants.

Findings
– Using the framework of social capital within the community of practice, this study has explored the use of informal regional network built by accounting principals for the efficient transfer of and access to knowledge between network members. When the knowledge became freely available, the cost of network building exceeded the benefits of belonging and the network collapsed.

Practical implications
– The paper has practical implications for accounting practitioners, particularly in regional/rural settings and for the accounting profession as a whole.

Originality/value
– First, very little is known about informal networks in knowledge-intensive firms stretched out in regional/rural settings. Second, the network in this study is different from many networks identified in the literature that have focused on innovation and competitive advantage. Finally, this study adopts a more integrated framework that explores how social capital is constituted and reconstituted in the network interaction process.
A study of the competency requirements of property development graduates to meet the qualifications of the South African construction industry
Authors: Ahmed Ezzat Othman Ayman 
Published: February 2014

Purpose– This paper aims to investigate the competency requirements of property development (PD) graduates at the University of KwaZulu-Natal (UKZN) as an approach to fulfil the qualifications of the construction industry in South Africa (SA).Design/methodology/approach– To achieve the above-mentioned aim, a research methodology is designed to accomplish three objectives. First, literature review is used to investigate the structure of the (PD) programme at (UKZN), National Qualifications Framework (NQF) and construction management (CM) education. Second, survey questionnaires are used to investigate the relevancy of the (PD) programme at (UKZN) towards meeting the (NQF) unit standards and the South African construction industry (SACI) requirements. Finally, summarising the conclusions and recommendations useful for future improvement of (PD/CM) education in SA. Collected data are analysed using the measure of central tendency and dispersion as well as Relative Importance Index (RII).Findings– Although the research revealed that the (PD) programme succeeded in graduating students who are adequately equipped to meet the expectations of the (SACI), a number of key areas and issues have been highlighted to enhance the (PD/CM) education in (SA) generally and (UKZN) in particular. Addressing these issues will increase the competency of (PD) graduates to meet the expectations of an ever-changing construction industry.Originality/value– This paper identifies the competency requirements of (PD) graduates at the KwaZulu-Natal region, a topic that received scant attention in construction literature and has not been previously undertaken in UKZN.
Innovation in footwear companies – does it pay off?
Authors: Filipa Soares Passos Cardoso Andreia , Torkkeli Marko 
Published: February 2014

Purpose
– Low- and medium-technology sectors' (LMTs) role in modern economies has been overshadowed by the argument relating knowledge creation to R&D and thus to high-tech industries. Nevertheless, whereas a broader definition of innovation has enabled LMTs to emerge as innovative environments, a blind reliance on non-R&D-based indicators may be harmful too by neglecting LMTs' contribution to the development of cutting-edge, R&D-based knowledge. This paper aims to provide answers to the following questions: do LMTs innovate? Do they induce high-tech innovations across other sectors? Do networks have an impact on LMTs' innovation commitment? Can LMTs' innovation commitment be related to a better performance?

Design/methodology/approach
– The research method used in this work was based on a case study approach using in-depth face-to-face interviews with representatives from two footwear companies and one technology supplier.

Findings
– Collaboration with relevant stakeholders along the footwear value chain proved fundamental to the creation of innovation opportunities for all parties involved. Both footwear companies have embraced innovation strategies, allowing them to take over new functions along the value chain and build successful international paths. These strategies involved active participation in cutting-edge, high-tech knowledge prompting innovation at higher-tech companies too.

Research limitations/implications
– The paper fails to establish a clear causative relationship between companies' performance and their R&DI commitment. In addition, due to the number of companies involved in the study, the findings cannot be simply extrapolated to the whole Portuguese footwear sector.

Originality/value
– The paper highlights the commitment to innovation in a traditional sector and explores an underresearched topic – that of LMTs' involvement in R&D activities.
Managing the manufacturing – R&D interface: an extended editorial viewpoint
Authors: Lager Thomas , Rennard Jean-Philippe 
Published: February 2014

Purpose
– This extended editorial viewpoint aims to introduce the individual contributions for this special issue.

Design/methodology/approach
– The articles included in this special issue are reviewed.

Findings
– The preliminary synthesis of all articles identifies four different perspectives on this topical area: a corporate strategy perspective, a cross-functional work-process perspective, an outsourcing perspective and a specific Chinese perspective.

Research limitations/implications
– Some of the articles in this special issue are of a theoretical character; thus, further empirical research is recommended.

Practical implications
– The individual papers present important information, guidelines and frameworks that firms can use in their efforts to bridge the manufacturing – R&D interface.

Originality/value
– This special issue focuses on a less-researched topical area and attempts to bridge the disciplines of operations and innovation management.
Law briefing
Authors: Dowden Malcolm 
Published: February 2014

Purpose
– This legal update examines the implications for commercial landlords of regulations required to be made under Energy Act 2011, and to come into force by 1 April 2018. Under those regulations, a landlord “may not let” commercial premises falling below a specified energy performance rating (likely to be E). The sanction of market deprivation arguably represents a significant shift in the balance between incentive and compulsion as the key policy tool adopted by the UK Government in seeking to improve the energy performance of commercial buildings. The paper aims to discuss these issues.

Design/methodology/approach
– The paper sets out and reflects a practitioner's concerns relating to the proposed new sanction of market deprivation. It identifies and highlights practical difficulties likely to be encountered when considering the interaction of the proposed regulations with existing statute (e.g. Landlord and Tenant Act 1954) and contractual provisions such as tenant break clauses.

Findings
– The prospect of being unable to let commercial premises that fall below a specified energy efficiency rating must focus landlord attention on rights to enter to carry out improvement works. The paper identifies a potentially significant trap for landlords in the model green lease clauses issued by the Better Buildings Partnership where tenant consent is required.

Research limitations/implications
– The paper does not reflect extensive or exhaustive academic research. Consistently with its purpose a legal update, it identifies key issues likely to be encountered by practitioners.

Practical implications
– The principal practical implication is the need for landlords and their professional advisors to consider as part of any current lease negotiations the need to secure rights of entry for landlords to carry out improvement works where premises are at risk of falling below the energy performance rating likely to be specified in regulations to be made under Energy Act 2011, s 49.

Originality/value
– The paper reflects a practitioner's views, developed through client matters and also through designing and delivering professional training sessions, on the likely implications of the requirement for regulations under Energy Act 2011.
Extending the viable system model scope on ICT-sector software projects in Castilla y León
Authors: César Puche Regaliza Julio 
Published: February 2014

Purpose
– This paper aims to extend the scope of the viable system model (VSM), which was developed by Stafford Beer in favour of its formalisation and practical application, to overcome the criticism about its abstract nature.

Design/methodology/approach
– This extension is achieved using the descriptive validation of a software project structural organisation based on the information that was obtained from the ICT sector set of companies in Castilla y León.

Findings
– The main conclusion of the study indicates deficiencies in the proactive environmental control of the software project. To overcome these shortcomings at least partially, the author proposes the use of integrated dynamic simulation models and Team Syntegrity. Finally, the analysis provides a detailed reference to diagnose or design a software project organisational structure with viability-defined characteristics. Such reference can be adapted to different fields by extrapolating its application in favour of the VSM universality.

Originality/value
– The originality is based on the VSM application in software projects organisation. The value is based on VSM formalisation and practical application, to overcome the criticism about its abstract nature.
76th Annual Meeting of the Association for Information Science and Technology (ASIS&T)
Authors: C. Klose Annamarie 
Published: February 2014

Purpose
– The purpose of this article is to report on sessions the author attended at the 2013 ASIS&T Conference.

Design/methodology/approach
– The approach is an informal review of sessions and events the author attended.

Findings
– This report condenses the author's notes from various events and sessions at the conference.

Originality/value
– This is an original conference report written after attending the conference.
Educational and enlightening 79th WLIC in Singapore! A report on selected events at IFLA 2013
Authors: Ghosh Maitrayee 
Published: February 2014

Purpose
– This report aims to summarize selected presentations of the International Federations of Librarians Associations and Institutions (IFLA) 79th world congress held at Suntec City centre, Singapore, and highlight Asian participation in the World Library and Information Congress (WLIC) 2013. In addition to its content, the IFLA congress provides opportunities to discuss emerging issues and best practices with colleagues, vendors, and consultants across the globe.

Design/methodology/approach
– Reports from the viewpoint of an IFLA 2013 congress participant and paper presenter; presents an overview of the selected events with more detail on some of the presented papers and Continuing Professional Development and Workplace Learning (CPDWL) workshop. IFLA congress attracts librarians from all sectors and work environments from around the globe. It is difficult to document the entire conference happenings in a single report because of its huge and diverse nature; therefore a selective approach is used.

Findings
– The WLIC in Singapore was one of the most exciting social and professional events of the year. Over the years, the author finds that IFLA congresses deliver the best value in professional development; the educational value of the IFLA congress that author has had attended is consistent and cost-beneficial.

Practical implications
– It is not possible for any one person to cover all aspects of IFLA; it contains presentation summary of selected papers maybe of particular interest to readers who missed these sessions.

Originality/value
– The Singapore congress was worthwhile and enlightening, revealing the diversity of current developments in library service delivery worldwide. This report summarizes information about the congress useful for professionals who did not attend.
Technique for histological control of surgical margins in lip cancer
Authors: Aoyagi Satoru , Hata Hiroo , Homma Erina , Shimizu Hiroshi 
Published: February 2014

AbstractTo preserve oral function and achieve acceptable cosmetic results, intraoperative control of surgical margins with frozen section evaluation may help to determine surgical technique in lip cancer. However, frozen section analysis is usually limited to suspicious areas and has not been systematically performed among surgeons. The accuracy of such analysis for detecting histological surgical margins is highly dependent on the methods used to obtain and analyze the margins. Improving the pathodiagnostic reliability of conventional intraoperative frozen section evaluation is the most important goal of surgical management in our method. We describe the successful use of the “double‐blade method” in lip cancer treatment. The technique we describe has the advantage of histologically confirming clear margins in lip cancer. This method appears to be time‐saving and easy to apply with existing surgical systems. In addition, this method may be used as an alternative to complete evaluation of lateral surgical margins that is important in planning a suitable surgical reconstruction procedure in lip cancer at many institutions where Mohs micrographic surgery is difficult to perform.
Pigmented condyloma acuminatum
Authors: Shimizu Akira , Kato Madoka , Ishikawa Osamu 
Published: February 2014

AbstractWe herein report a case of pigmented condyloma acuminatum in the genital region. A histopathological examination revealed keratinocyte proliferation, papillomatosis and basal pigmentation. Cellular atypia was rarely observed. The patient also had ordinary skin‐colored nodules on the coronal sulcus. Polymerase chain reaction amplification with consensus primers for human papillomavirus (HPV) and subsequent sequencing confirmed an infection of HPV type 6. Pigmented condyloma acuminatum is not rare; however, making the differential diagnosis between bowenoid papulosis and seborrheic keratosis is sometimes difficult. The mechanism of pigmentation in such cases remains unknown and requires further investigation. HPV typing is a useful method for diagnosing the disease.
Solving the complex near‐surface problem using 3D data‐driven near‐surface layer replacement
Authors: Sun Yimin , Verschuur Eric , Vrolijk Jan Willem 
Published: February 2014

ABSTRACTIn many land seismic situations, the complex seismic wave propagation effects in the near‐surface area, due to its unconsolidated character, deteriorate the image quality. Although several methods have been proposed to address this problem, the negative impact of 3D complex near‐surface structures is still unsolved to a large extent. This paper presents a complete 3D data‐driven solution for the near‐surface problem based on 3D one‐way traveltime operators, which extends our previous attempts that were limited to a 2D situation. Our solution is composed of four steps: 1) seismic wave propagation from the surface to a suitable datum reflector is described by parametrized one‐way propagation operators, with all the parameters estimated by a new genetic algorithm, the self‐adjustable input genetic algorithm, in an automatic and purely data‐driven way; 2) surface‐consistent residual static corrections are estimated to accommodate the fast variations in the near‐surface area; 3) a replacement velocity model based on the traveltime operators in the good data area (without the near‐surface problem) is estimated; 4) data interpolation and surface layer replacement based on the estimated traveltime operators and the replacement velocity model are carried out in an interweaved manner in order to both remove the near‐surface imprints in the original data and keep the valuable geological information above the datum. Our method is demonstrated on a subset of a 3D field data set from the Middle East yielding encouraging results.
Sexual Dimorphism in Finger Ridge Breadth Measurements: A Tool for Sex Estimation from Fingerprints
Authors: Mundorff Amy Z. , Bartelink Eric J. , Murad Turhon A. 
Published: February 2014

AbstractPrevious research has demonstrated significant sexual dimorphism in friction ridge skin characteristics. This study uses a novel method for measuring sexual dimorphism in finger ridge breadths to evaluate its utility as a sex estimation method from an unknown fingerprint. Beginning and ending in a valley, the width of ten parallel ridges with no obstructions or minutia was measured in a sample of 250 males and females (N = 500). The results demonstrate statistically significant differences in ridge breadth between males and females (p < 0.001), with classification accuracy for each digit varying from 83.2% to 89.3%. Classification accuracy for the pooled finger samples was 83.9% for the right hand and 86.2% for the left hand, which is applicable for cases where the digit number cannot be determined. Weight, stature, and to a lesser degree body mass index also significantly correlate with ridge breadth and account for the degree of overlap between males and females.
Increased expression of CSP and CYP genes in adult silkworm females exposed to avermectins
Authors: Xuan Ning , Guo Xia , Xie Hong‐Yan , Lou Qi‐Nian , Lu Xing‐Bo , Liu Guo‐Xia , Picimbon Jean‐François 
Published: February 2014

AbstractWe analyzed 20chemosensory protein(CSP) genes of the silkwormBombyx mori. We found a high number of retrotransposons inserted in introns. We then analyzed expression of the 20BmorCSPgenes across tissues using quantitative real‐time polymerase chain reaction (PCR). Relatively low expression levels ofBmorCSPs were found in the gut and fat body tissues. We thus tested the effects of endectocyte insecticide abamectin (B1a and B1b avermectins) onBmorCSPgene expression. Quantitative real‐time PCR experiments showed that a single brief exposure to insecticide abamectin increased dramatically CSP expression not only in the antennae but in most tissues, including gut and fat body. Furthermore, our study showed coordinate expression ofCSPsand metaboliccytochrome P450 enzymesin a tissue‐dependent manner in response to the insecticide. The function of CSPs remains unknown. Based on our results, we suggest a role in detecting xenobiotics that are then detoxified by cytochrome P450 anti‐xenobiotic enzymes.