bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motor sequence learning elicits mu peak-specific corticospinal plasticity
Authors: Suresh Tharan , Iwane Fumiaki , Zhang Minsu , McElmurry Margaret , Manesiya Muskan , Freedberg Michael V , Hussain Sara J 
Published: August 2024

AbstractMotor cortical (M1) transcranial magnetic stimulation (TMS) interventions increase corticospinal output and improve motor learning when delivered during sensorimotor mu rhythm trough but not peak phases, suggesting that the mechanisms supporting motor learning may be most active during mu trough phases. Based on these findings, we predicted that motor sequence learning-related corticospinal plasticity would be most evident when measured during mu trough phases. Healthy adults were assigned to either a sequence or no-sequence group. Participants in the sequence group practiced the implicit serial reaction time task (SRTT), which contained an embedded, repeating 12-item sequence. Participants in the no-sequence group practiced a version of the SRTT that contained no sequence. We measured mu phase-independent and mu phase-dependent MEP amplitudes using EEG-informed single-pulse TMS before, immediately after, and 30 minutes after the SRTT in both groups. All participants performed a retention test one hour after SRTT acquisition. In both groups, mu phase-independent MEP amplitudes increased following SRTT acquisition, but the pattern of mu phase-dependent MEP amplitude changes after SRTT acquisition differed between groups. Relative to the no-sequence group, the sequence group showed greater peak-specific MEP amplitude increases 30 minutes after SRTT acquisition. Further, the magnitude of these peak-specific MEP amplitude increases was negatively associated with the magnitude of sequence-specific learning. Contrary to our original hypothesis, results revealed that motor sequence-specific learning elicits peak-specific corticospinal plasticity. Findings provide first direct evidence for the presence of a mu phase-dependent motor learning mechanism in the human brain.New and NoteworthyRecent work suggests that motor learning’s neural mechanisms may be most active during specific sensorimotor mu rhythm phases. If so, motor sequence learning-induced corticospinal plasticity should be more evident during some mu phases than others. Our results show that motor sequence-specific learning elicits corticospinal plasticity that is most prominent during mu peak phases. Further, this peak-specific plasticity correlates with learning. Findings establish the presence of a mu phase-dependent motor learning mechanism in the human brain.
Discrete protein condensation events govern calcium signal dynamics in T cells
Authors: Morita Shumpei , O’Dair Mark K. , Groves Jay T. 
Published: August 2024

AbstractCalcium level variations, which occur downstream of T cell receptor (TCR) signaling, are an essential aspect of T cell antigen recognition. Although coordinated ion channel activities are known to drive calcium oscillations in other cell types, observations of nonperiodic and heterogeneous calcium patterns in T cells are inconsistent with this mechanism. Here, we track the complete ensemble of individual molecular peptide-major histocompatibility complex (pMHC) binding events to TCR, while simultaneously imaging LAT condensation events and calcium level. Individual LAT condensates induce a rapid and additive calcium response, which quickly attenuates upon condensate dissolution. No evidence of cooperativity between LAT condensates or oscillatory calcium response was detected. These results reveal stochastic LAT protein condensation events as a primary driver of calcium signal dynamics in T cells.One-Sentence SummaryCa2+fluctuations in T cells reflect stochastic protein condensation events triggered by single molecular antigen-TCR binding.
Laminin 111 triggers cell quiescence and long-term survival by inducing IQGAP1-mediated cytosolic scaffolding of ERK and BAD inactivation
Authors: Yu Chunhong , Malijauskaite Sigita , Hinze Claudia , Franzoni Marco , Hickey Séamus , Marcar Lynnette , Peak-Chew Sew Yeu , Cryar Adam , Bain Charlie , Marsden Jane , Allardyce Joanna M. , Mendes-Pereira Ana Maria , McMahon Harvey T. , Thalassinos Konstantinos , McGourty Kieran , Boucrot Emmanuel 
Published: August 2024

SUMMARYIn an adult human body, only a minority (∼1%) of cells are dividing; all others are either quiescent, senescent or terminally differentiated. Cellular quiescence, also called G0, is a reversible non-proliferative state in which cells, such as adult stem cells, exist until stimuli trigger their re-entry into the cell cycle. Quiescent cells are known to reside within microenvironment niches of specific extracellular matrix (ECM) composition, but the molecular mechanisms that control their entry and maintenance into G0 and their long-term survival are poorly understood. Here, using a reproducible and homogenousin vitromodel of quiescence,ex vivotissue histology, phosphoproteomics, and molecular cell biological assays, we revealed that Laminin 111 was sufficient to trigger i) reversible cell cycle exit into G0; ii) sustained and elevated MAPK/ERK signaling; and iii) long-term survival. We found that ERK was activated through the Rap1-BRAF-MEK arm underneath Laminin-binding Integrin α3β1. Activated pERK was scaffolded into the cytoplasm by IQGAP1, thereby blocking its translocation into the nucleus and the activation of proliferative transcription factors. Instead, cytoplasmic pERK inhibited pro-apoptotic protein BAD, which mediated the survival of quiescent cells even in absence of mitogen stimuli. Importantly, we confirmed that pERK was elevated and retained in the cytoplasm of Lgr5+stem cells when they were located within Laminin α1-positive niches in porcine intestine. These findings uncovered a molecular mechanism that may explain how quiescent cell pools, such as dormant adult stem cells, can survive many years despite low mitogen stimuli and be resistant to apoptotic challenges, including chemotherapy.HIGHLIGHTSLaminin 111 is sufficient to induce cellular quiescence (G0) and long-term survival.Laminin 111 triggers the sustained and elevated activation of ERK during G0.ERK is activated not by growth factor receptors but through the Rap1-BRAF-MEK arm underneath Laminin-binding Integrin α3β1.Active, phosphorylated ERK (pERK) is scaffolded by IQGAP1, which prevents it from translocating into the nucleus and activating proliferative transcription factors.Instead, cytoplasmic pERK mediates the phosphorylation, and thus inhibition, of BAD, thereby raising the threshold at which G0 cells enter apoptosis.
The impact of R&D classification shifting in high-technology industries
Authors: Qiao Nika 
Published: July 2024

PurposeThis study investigates the motivations and consequences of classification shifting from cost of sales to research and development (R&D) in high-technology industries.Design/methodology/approachThis study conducts a multivariate analysis using logistic and ordinary least squares regression methods on panel data of high-technology firms for the period 1988–2012 to examine the effect of R&D classification shifting on gross margin benchmarks and future performance.FindingsThe results show that R&D classification shifting increases the likelihood of meeting or beating gross margin benchmarks. They also show that firms engaged in R&D classification shifting exhibit lower future R&D productivity, stock returns, and operating performance. The findings indicate that the short-term benefits of achieving gross margin benchmarks are offset by the long-term negative impact of R&D misclassification.Practical implicationsThis paper provides insights that can help regulators develop clearer guidelines for the appropriate classification of R&D costs.Originality/valueMoving beyond the core earnings management paradigm, this study demonstrates the use of R&D classification shifting as a tool to manipulate gross profits and R&D in high-technology industries. Most prior studies focused on the determinants of R&D classification shifting, while few investigated the impact of the practice. The findings in this study provide initial evidence of the consequences of R&D classification shifting for future R&D productivity and firm performance in high-tech industries. Using five methods, this study also validates R&D classification shifting and addresses the alternative explanation of R&D overinvestment.
Amigos de la Hoja de Coca: history of a pioneering coca leaf fair-trade
Authors: Ghehiouèche Farid , Riboulet-Zemouli Kenzi 
Published: July 2024

Purpose
The leaves of the Erythroxylum “coca” plant are a well-known food, beverage, and nutraceutical in their native Andean region. A decade ago, the European non-profit “Amigos de la Hoja de Coca” (Friends of the Coca Leaf) operated a short-lived fair-trade in raw coca leaves between Bolivia and the European Union. The chronicles of this initiative can be insightful, as interest in natural, wellness, and self-care products continues rising in Europe.

Design/methodology/approach
Historical review of the inception, and documentation of the organisation of the scheme and its outcome, via all primary sources available.

Findings
From the 1990s to the early 2010s, civil society groups organised several campaigns to normalise coca leaf in Europe, finding echo at the European Parliament, culminating in 2012-2013 when a periodical distribution system was set-up: growers in Bolivia shipped 150 g. coca leaf packets directly to Friends of the Coca Leaf members in Europe. Initially, most parcels reached their recipients without issue but after technical hurdles and reduced political support, the scheme was eventually discontinued.

Originality/value
European civil society campaigns surrounding coca have been poorly documented. Historically, Friends of the Coca Leaf emerged alongside Cannabis social clubs, but only the latter has prospered. While Friends of Coca Leaf was short-lived, its political outcomes (both at the institutional level and via a fair and do-it-yourself trade initiative) may prove inspirational to current drug policy reform discussions.
A review on American senior housing and financing decisions
Authors: He Wei , Gao Wenqing , Jia Shaomeng 
Published: July 2024

Purpose
The world population is getting older and housing decisions matter to the security of retirement life and well-being. However, senior housing and financing decisions are largely overlooked in the literature. This study aims to provide a comprehensive overview of the senior housing and financing decisions in the USA.

Design/methodology/approach
Using 2021 American Housing Survey data and ordinary least squares estimates, this paper studies senior housing and financing decisions in the 15 most populous US metropolitan areas. Multiple regressions are used to analyze the whole sample as well as various subsamples.

Findings
This paper finds strong evidence that seniors are more likely to own a house with a higher market value compared with nonseniors. More specifically, although race and gender do not matter in this relationship, it is less pronounced among those with higher education. Also, seniors, especially white senior homeowners, are more likely to have a lower mortgage debt burden due to a higher upfront down payment than nonseniors. Last, seniors are more likely to refinance their homes and receive cash than nonseniors.

Research limitations/implications
Constrained by the data limitations, this study specifically focuses on seniors’ housing and mortgage decisions. Future research could involve exploring seniors’ mortgage decisions by considering factors such as mortgage loan terms, borrower credentials and the evolving landscape of the senior housing market, among other aspects.

Practical implications
The findings would help policymakers and contractors in the construction industry better understand the uniqueness of challenges in the senior housing market and develop effective housing policies and programs that cater to the needs of the elderly. A comprehensive understanding of the senior housing market would also help seniors make informed purchase and financing decisions.

Social implications
The authors propose providing financial education to the elderly, particularly those of disadvantaged status, to improve their expertise and bargaining skills in the mortgage loan application process.

Originality/value
This paper contributes to understanding the dynamic senior housing market, which encounters challenges and opportunities associated with the aging population. The study fills the gap of limited research regarding seniors’ housing decision and their financing choices in the USA and would help policymakers and contractors in the construction industry develop effective housing policies and programs that cater to the needs of the elderly.
Housing finance inaccessibility for Saudi Arabia’s low-income employees: are housing-related sustainable development goals 2030 under threat?
Authors: Alharbi Raed Khamis 
Published: July 2024

Purpose
In developing countries, including achieving Kingdom of Saudi Arabia’s (KSA) Vision 2030, housing loans for low-income employees are challenging and may thwart housing-related sustainable development goals (SDGs). Studies investigating housing finance inaccessibility for KSA Vision 2030 low-income earners and its impact on achieving housing-related SDGs are scarce. Hence, this study aims to investigate KSA housing financial inaccessibility and its effect on housing-related SDGs. Also, it offered suggestions for achieving housing provision in Vision 2030 and, by extension, improving housing-related SDGs.

Design/methodology/approach
The study adopted a virtual interview approach and covered Alqassim, Riyadh and Medina. The researcher engaged 24 participants who were knowledgeable about KSA’s housing finance and SDGs. They include selected low-income earners, academicians, financial operators and government ministries/departments/agencies. The study manually analysed the collated data through a thematic approach and presented the main themes.

Findings
Findings reveal that KSA’s low-income earners’ housing finance inaccessibility threatens Vision 2030 and housing-related SDGs. Inadequate funding of the Real Estate Development Fund, inability to make down payment, absence of collateral, insufficient household income and failure to recover the loan and associated charges from the auction were perceived major issues contributing to low-income earners’ house-loan rejection and recommended measures to improve achieving housing-related SDGs.

Originality/value
The study investigated the factors contributing to low-income earners’ housing loan rejection and its impact on achieving KSA’s Vision 2030 and housing-related SDGs from the participants’ perspective. The findings reveal that low-income earners’ housing finance accessibility has been compounded by the slow recovery from the post-COVID-19 pandemic.
Crisis volunteering during COVID-19 pandemic in India: youth responds to health and human rights crisis
Authors: Shashwati Sudha , Sarin Sanjana , Jain Umang , Singh Sanna 
Published: July 2024

Purpose
This study aims to explore the experiences of individuals in India who acted as informal crisis volunteers during the peak of the deadliest wave of the COVID-19 pandemic in the country.

Design/methodology/approach
An exploratory, qualitative design was used, and data gathered via a qualitative survey in three focus areas, namely, motivation, challenges and coping mechanisms. The sample (n = 112) comprised individuals (mean age = 21.89 years) whose volunteering efforts during the second wave of the COVID-19 pandemic were extended as part of volunteer groups or individually, online or offline, for minimum of 10 consecutive days to four months. Descriptive statistics and qualitative content analysis (Mayring, 2000) were used to analyze the data.

Findings
Most of the participants reported being inspired by social media activism to become crisis volunteers themselves. They also spoke of several human rights violations unfolding around them, namely, people denied right to health (availability and accessibility), rampant discrimination of various kinds and other systemic failures in crisis response by government bodies. Several reported undergoing extreme mental duress during the process, experiencing or witnessing harassment and dealing with corruption. A sense of collective identity and opportunities to engage in collective sense making and collective catharsis with fellow volunteers were reported as the most helpful coping mechanism.

Originality/value
Very little is known about the experience of informal crisis volunteers who assisted the public health system in India in various capacities during the pandemic. This paper explores those experiences, sheds light on various human rights violations that took place during the time and provides a glimpse into the potential of technology and social media in organized altruistic efforts.
How curiosity affects contextual performance: an emotional daily dynamics perspective
Authors: Junça Silva Ana , Caetano António 
Published: July 2024

PurposeThis research relied on the broaden-and-build (B&B) theory to explore emotional predictors for curiosity-related differences in daily engagement and contextual performance. We tested a moderated mediation model, arguing that daily positive emotions would be related to daily work engagement and contextual performance.Design/methodology/approachA total of 586 participants participated in a five-day diary study (n = 2379).FindingsMulti-level modeling showed that, at the person level of analysis, daily positive emotions were significantly and positively related to daily work engagement and, in turn, daily performance. At the daily level of analysis, the mediation model was moderated by curiosity, such that it became stronger for individuals who scored higher on curiosity.Originality/valueThese findings make relevant theoretical contributions to understanding the power of curiosity for daily emotional dynamics in organizations. Compared to traditional between-person variables, these results also expand knowledge on within-person processes that explain daily work engagement and contextual performance. In sum, this study shows that “curiosity does not kill the cat”; instead, it makes it productive.
Caries and periodontal health status of male inmates: a retrospective study conducted in a French prison
Authors: Ancely Astrid , Laurencin-Dalicieux Sara , Baussois Catherine , Blanc Anthony , Nabet Cathy , Thomas Charlotte , Fournier Géromine 
Published: July 2024

Purpose
The purpose of this study is to describe the oral health status of inmates. The secondary aims were to compare recidivists with first-time offenders and also study the impact of psychoactive drugs on the oral health status.

Design/methodology/approach
This retrospective study included 120 male inmates from a French prison. Data from the medical and the dental questionnaires and examinations were collected and analyzed.

Findings
The results showed that overall, the inmates had a poor oral health despite their young age. This population was at high risk regarding caries and periodontal diseases due to sedentary behaviors, improper diet, drug, alcohol and tobacco consumption. In total, 93% of inmates had at least one decayed untreated tooth and 95% had periodontal disease. The use of psychoactive drugs seemed strongly related to oral health status degradation. However, the comparison between recidivists and first-time offenders showed few differences.

Practical implications
The need for periodontal and dental care is considerable in this population and increased in this environment where risk factors such as addictive behaviors and poor eating habits are common. The impact of psychoactive drugs on oral health should also be taken into consideration.

Social implications
Unfortunately, even though strategies for the prevention and management of oral health in prisons have been put in place for some years, the results still seem insufficient.

Originality/value
There are still few studies that analyze the impact of this medication on oral health in prisons.
In-store augmented reality design: fashion retail’s perspectives
Authors: Xue Liangchao , Parker Christopher J. , Hart Cathy 
Published: July 2024

PurposeFashion retail has faced immense changes in the rapid development of e-commerce, creating significant uncertainty about physical stores’ future. To improve the consumer shopping experience and increase sales revenue for fashion retailers, this paper investigates how Augmented Reality (AR) can be implemented within high-street fashion retail by exploring leading UK retailers’ reactions to pragmatic future scenarios.Design/methodology/approachThis study conducted qualitative research through 13 interviews – eight retail staff from high-street and high-end markets and five AR/UX designers regarding their insights into how AR can enhance consumer engagement at each market level.FindingsThe results showed that the fashion retail market is ill-prepared to use AR. AR could help high-street brands offer a seamless shopping experience for consumers by prioritising the functional purpose but exciting AR animation. This would offer consumers an efficient and enjoyable shopping experience. While implementing AR, high-end stores should tell stories through hedonic engagement, letting consumers efficiently engage with brand messages, since building an AR ecosystem is cheaper than creating the story flow physically.Originality/valueThe study devises 16 retailer-supported guidelines for designing AR for Fashion Retail levels to guide innovators and retailers.
Defining and cultivating creative citizenship in northern Thailand: enhancing urban livability through sustainable tourism
Authors: Srichai Pachernwaat , Thapatiwong Archabaramee , Tistueng Kingkaew 
Published: July 2024

Purpose
This qualitative investigation is one of a series of sub-investigations under an umbrella project to develop Lampang Creative Livable Tourist City. The aim of this paper is to explore the integration of sustainable tourism into the development of Lampang, a city in northern Thailand. By collaborating with government and private agencies, academics, community leaders and the people of Lampang to reskill and upskill core community groups in the city, the researchers hope to enhance active citizenship, develop relevant skills and foster leadership networks that boost Lampang’s appeal as a sustainable tourism destination.

Design/methodology/approach
Data were gathered from brainstorming meetings, focus group discussions, observations and in-depth interviews. After identifying key characteristics required for creative citizens of Lampang city, the researchers developed and implemented pilot curricula with five target groups. Activities were developed to nurture creative leaders and promote innovative use of traditional culture and lifestyle.

Findings
The findings revealed that targeted local curricula can harness the cultural capital of the local community and equip locals with a modern toolkit to lay the foundations for a creative, livable tourist city.

Originality/value
This study’s originality lies in its grassroots approach to defining creative citizenship. It captures local community perspectives on what constitutes a creative citizen. Moreover, this research demonstrates how custom-designed educational initiatives can effectively nurture a creative and resilient urban ecosystem. This offers a blueprint for culturally informed urban regeneration, highlighting the role of sustainable tourism in enhancing the city’s attractiveness and livability for both residents and visitors.