bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodological framework to identify possible adverse drug reactions using population-based administrative data
Authors: Sauer Brian C. , Nebeker Jonathan , Shen Shuying , Rupper Randall , West Suzanne , Shinogle Judith A. , Xu Wu , Lohr Kathleen N. , Samore Matthew 
Published: October 2014

Purpose: We present a framework for detecting possible adverse drug reactions (ADRs) using the Utah Medicaid administrative data. We examined four classes of ADRs associated with treatment of dementia by acetylcholinesterase inhibitors (AChEIs): known reactions (gastrointestinal, psychological disturbances), potential reactions (respiratory disturbance), novel reactions (hepatic, hematological disturbances), and death.Methods: Our cohort design linked drug utilization data to medical claims from Utah Medicaid recipients. We restricted the analysis to 50 years-old and older beneficiaries diagnosed with dementia-related diseases. We compared patients treated with AChEI to patients untreated with anti-dementia medication therapy. We attempted to remove confounding by establishing propensity-score-matched cohorts for each outcome investigated; we then evaluated the effects of drug treatment by conditional multivariable Cox-proportional-hazard regression. Acute and transient effects were evaluated by a crossover design using conditional logistic regression.Results: Propensity-matched analysis of expected reactions revealed that AChEI treatment was associated with gastrointestinal episodes (Hazard Ratio [HR]: 2.02; 95%CI: 1.28-3.2), but not psychological episodes, respiratory disturbance, or death. Among the unexpected reactions, the risk of hematological episodes was higher (HR: 2.32; 95%CI: 1.47-3.6) in patients exposed to AChEI. AChEI exposure was not associated with an increase in hepatic episodes. We also noted a trend, identified in the case-crossover design, toward increase odds of experiencing acute hematological events during AChEI exposure (Odds Ratio: 3.0; 95% CI: 0.97 - 9.3).Conclusions: We observed an expected association between AChEIs treatment and gastrointestinal disturbances and detected a signal of possible hematological ADR after treatment with AChEIs in this pilot study. Using this analytic framework may raise awareness of potential ADEs and generate hypotheses for future investigations. Early findings, or signal detection, are considered hypothesis generating since confirmatory studies must be designed to determine if the signal represents a true drug safety problem.
Residential Transitions Among Adults With Intellectual Disability Across 20 Years
Authors: Woodman Ashley C. , Mailick Marsha R. , Anderson Kristy A. , Esbensen Anna J. 
Published: October 2014

The present study addresses critical gaps in the literature by examining residential transitions among 303 adults with intellectual disability (ID) over 10 years (Part 1) and 75 adults with Down syndrome over 20 years (Part 2). All adults lived at home at the start of the study, but many moved to a variety of settings. Several characteristics of the adults with ID differed across settings, most notably adaptive behavior and the number of residential transitions, whereas characteristics such as age, type of disability, and behavior problems were less predictive of residential placements. The number of moves over the course of the study varied widely, with critical links to earlier family dynamics, social relationships, and health and adaptive behavior.
Early Mastery Motivation as a Predictor of Executive Function in Young Adults With Developmental Disabilities
Authors: Hauser-Cram Penny , Woodman Ashley Cynthia , Heyman Miriam 
Published: October 2014

The role of early childhood mastery motivation as a predictor of executive function 20 years later was examined in a sample of 39 individuals who had early diagnosed developmental disabilities. Multilevel modeling was used to analyze predictors of accuracy and response time on a Flanker task measuring executive function. As predicted, participants had relatively poorer performance on trials requiring inhibition and rule switches. Individuals with Down syndrome, in comparison to other participants, demonstrated longer response times. Young adults who had higher levels of persistence on mastery motivation tasks during early childhood displayed higher levels of accuracy and shorter response times on the executive function task. Possible mechanisms by which early mastery motivation relates to later executive function are discussed.
Joint Diseases in Animal Paleopathology: Veterinary Approach
Authors: Stevanović Oliver , Janeczek Maciej , Chrószcz Aleksander , Marković Nemanja 
Published: October 2014

Abstract
Animal paleopathology is not a very well known scientific discipline within veterinary science, but it has great importance for historical and archaeological investigations. In this paper, authors attention is focused on the description of one of the most common findings on the skeletal remains of animals - osteoarthropathies. This review particularly emphasizes the description and classification of the most common pathological changes in synovial joints. The authors have provided their observations on the importance of joint diseases in paleopathology and veterinary medicine. Analysis of individual processes in the joints of the animals from the past may help in the understanding of diseases in modern veterinary medicine. Differential diagnosis was made a point of emphasis and discussion, so that this work could have practical significance for paleopathology and veterinary medicine.
Hypoxia Tolerance of Larvae and Pupae of the Semi-Terrestrial Caddisfly (Trichoptera: Limnephilidae)
Authors: Cavallaro M C , Hoback W W 
Published: October 2014

Abstract
The caddisfly, Ironoquia plattensis Alexander and Whiles, is a benthic macroinvertebrate endemic to the backwater sloughs and prairie wetlands in central Nebraska. These areas are subject to spring rains which wane to subsequent drying, and I. plattensis larvae are adapted to this hydric cycle, partitioning time as larvae in water and on land. Flooding, especially soil flooding, causes severe hypoxia, and most terrestrial organisms that are trapped underwater drown in a short period of time. Shallow, warm waters (&gt;30°C) and aquatic environments that receive high nutrients can also experience severe hypoxia as a result of algal blooms, decomposition, and high biological oxygen demand. We exposed aquatic larvae, terrestrial larvae, and pupae of I. plattensis to severely hypoxic water and found that pupae were most sensitive, having a lethal time to 50% mortality (LT50) of 3.14 and 7.67 h, at 20 and 10°C, respectively. Aquatic fifth instars had an LT50 of 44.17 and 74.21 h and terrestrial larvae survived 61.68 and 89.89 h, at 20 and 10°C, respectively. The hypoxia tolerance of terrestrial larval stages suggests an adaptation to flooding while the sensitivity of the pupal stage suggests that fall flooding could cause significant mortality.
Cyclosporine A Enhances Gingival β‐Catenin Stability via Wnt Signaling
Authors: Tu Hsiao‐Pei , Chen Yen‐Teen , Fu Earl , Shen E‐Chin , Wu Meng‐Hsun , Chen Yen‐Lin , Chiang Cheng‐Yang , Chiu Hsien‐Chung 
Published: October 2014

Background: Cyclosporine A (CsA) increases β‐catenin messenger RNA (mRNA) and protein expression. The present study demonstrates that Wnt/β‐catenin signaling inhibits β‐catenin degradation in the gingiva.Methods: Forty 5‐week‐old male Sprague‐Dawley rats were assigned to two study groups after healing from right maxillary molar extractions. The rats in the experimental group were fed 30 mg/kg CsA daily for 4 weeks, whereas the control rats were fed mineral oil. At the end of the study, all rats were sacrificed, and the gingivae were obtained. The gingival morphology after CsA treatment was evaluated by histology, and the genes related to Wnt/β‐catenin signaling were initially screened by microarray. Polymerase chain reaction, Western blotting, and immunohistochemistry were used to examine the mRNA and protein expression of proliferating cell nuclear antigen, cyclin D1, E‐cadherin, β‐catenin, Dvl‐1, glycogen synthase kinase‐3β, axin‐1, and adenomatous polyposis coli (APC). Phosphoserine and ubiquitinylated β‐catenin were detected after immunoprecipitation.Results: In rats treated with CsA, overgrowth of gingivae was observed, and altered expression of genes related to Wnt/β‐catenin signaling was detected by the microarray. The gingival mRNA and protein expression profiles for genes associated with Wnt/β‐catenin signaling further confirmed the effect of CsA: β‐catenin and Dvl‐1 expression increased, but APC and axin‐1 expression decreased. Western blotting and immunohistochemistry showed decreases in β‐catenin serine phosphorylation (33/37) and ubiquitinylation in the gingivae of CsA‐treated rats.Conclusion: CsA‐enhanced gingival β‐catenin stability may be involved in gene upregulation or β‐catenin degradation via the Wnt/β‐catenin pathway.
Evaluation of the marginal fit of full ceramic crowns by the microcomputed tomography (micro-CT) technique
Authors: Demir Necla , Ozturk Atiye Nilgun , Malkoc Meral Arslan 
Published: October 2014

ABSTRACT
Objective: To evaluate the marginal gap (MG) and absolute marginal discrepancy (MD) of full ceramic crowns with two finish line designs, shoulder and chamfer, using microcomputed tomography (micro-CT) before and after cementation. Materials and Methods: Sixty extracted human maxillary premolar teeth were divided into two groups based on the finish line design: Group I: 90° shoulder and Group II: 135° chamfer. The specimens were further grouped based on the type of full ceramic crown they received: Group A: Feldspathic Cerec inLab ceramic system, Group B: Cerec inLab aluminum oxide ceramic system and Group C: Lithium disilicate press ceramic system. Before cementation, five crowns from each group were scanned using micro-CT in two sections, sagittal and coronal, to determine the MG and MD values for four regions of the crown (sagittal buccal, sagittal lingual, coronal mesial and coronal distal). After cementation and thermal cycling, the scanning was repeated. Measurements were obtained from 10 points for each region, 80 points totally, to evaluate the MG and MD values. Files were processed using NRecon and CTAn software. Results were statistically analyzed using one- and two-way ANOVA and Tukey HSD tests (P = 0.05). Results: Full ceramic systems showed clinically acceptable marginal adaptation values. The Feldspathic Cerec inLab ceramic system generally presented the lowest variance, except in the MG values of the coronal mesial region. The MG and MD values of all ceramics increased significantly after cementation, except in the shoulder preparation design (sagittal buccal region) for MG and in the chamfer preparation design (sagittal lingual region) for MD values. Conclusions: Full-ceramic crowns showed clinically acceptable marginal adaptation values. The Feldspathic Cerec inLab ceramic system (Vitablocs Mark II) generally presented the lowest variance when compared with the other ceramics, except for the MG values on the mesial surface of the coronal section.
Geometric analysis of root canals prepared by single twisted file in three different operation modes
Authors: Wu Xing-Chen , Zhu Ya-Qin 
Published: October 2014

ABSTRACT
Objective: The aim of this study was to evaluate and compare the effects of a single twisted file (TF) instrument in three different operation modes on the preparation of curved root canals in human molars and to explore a new possible method in canal shaping in the clinic setting. Materials and Methods: A total of 105 selected root canals with an angle of curvature ranging from 20° to 35° were divided into the following three groups with 35 samples each according to the different operation mode in canal preparation: “continuous rotation-500” (CR, 500 rpm), reciprocating movement-300 (RM-300 rpm) and CR-300 rpm. Root canals were prepared by single file (a size 25/0.06 TF). The pre- and post-instrumented images of the sections were scanned using a cone-beam computed tomography scanner to measure the root transportation and centering ratio. The data were evaluated at 1.5 mm, 3.0 mm and 6.0 mm positions from the apex. The significance level was set at P < 0.05. Results: The results showed a statistically significant difference in root transportation that was only found in cross-sections 3.0 mm from the anatomic apex between group “CR-500” and group “CR-300.” In addition, a significant difference in centering ratio was found between group “RM-300” and group “CR-300.” There was no significant difference in the two indices among the three groups at cross-sections 1.5 mm and 6 mm from the apex. Conclusions: Under the three conditions of this study, the continuous rotation mode has better shaping ability in root canal preparation than the RM mode when used with a TF single file (size 25/0.06).
Pharmacogenetic Variants and Plasma Concentrations of Antiseizure Drugs
Authors: Milosavljević Filip , Manojlović Marina , Matković Lena , Molden Espen , Ingelman-Sundberg Magnus , Leucht Stefan , Jukić Marin M. 
Published: August 2024

ImportancePrecise estimation of a patient’s drug metabolism capacity is important for antiseizure dose personalization.ObjectiveTo quantify the differences in plasma concentrations for antiseizure drugs associated with variants of genes encoding drug metabolizing enzymes.Data SourcesPubMed, Clinicaltrialsregister.eu, ClinicalTrials.gov, International Clinical Trials Registry Platform, and CENTRAL databases were screened for studies from January 1, 1990, to September 30, 2023, without language restrictions.Study SelectionTwo reviewers performed independent study screening and assessed the following inclusion criteria: appropriate genotyping was performed, genotype-based categorization into subgroups was possible, and each subgroup contained at least 3 participants.Data Extraction and SynthesisThe Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines were followed for data extraction and subsequent quality, validity, and risk-of-bias assessments. The results from the included studies were pooled with random-effect meta-analysis.Main Outcomes and MeasuresPlasma concentrations of antiseizure drugs were quantified with the dose-normalized area under the concentration-time curve, the dose-normalized steady state concentration, or the concentrations after a single dose at standardized dose and sampling time. The ratio of the means was calculated by dividing the mean drug plasma concentrations of carriers and noncarriers of the pharmacogenetic variant.ResultsData from 98 studies involving 12 543 adult participants treated with phenytoin, valproate, lamotrigine, or carbamazepine were analyzed. Studies were mainly conducted within East Asian (69 studies) or White or European (15 studies) cohorts. Significant increases of plasma concentrations compared with the reference subgroup were observed for phenytoin, by 46% (95% CI, 33%-61%) in CYP2C9 intermediate metabolizers, 20% (95% CI, 17%-30%) in CYP2C19 intermediate metabolizers, and 39% (95% CI, 24%-56%) in CYP2C19 poor metabolizers; for valproate, by 12% (95% CI, 4%-20%) in CYP2C9 intermediate metabolizers, 12% (95% CI, 2%-24%) in CYP2C19 intermediate metabolizers, and 20% (95% CI, 2%-41%) in CYP2C19 poor metabolizers; and for carbamazepine, by 12% (95% CI, 3%-22%) in CYP3A5 poor metabolizers.Conclusions and RelevanceThis systematic review and meta-analysis found that CYP2C9 and CYP2C19 genotypes encoding low enzymatic capacity were associated with a clinically relevant increase in phenytoin plasma concentrations, several pharmacogenetic variants were associated with statistically significant but only marginally clinically relevant changes in valproate and carbamazepine plasma concentrations, and numerous pharmacogenetic variants were not associated with statistically significant differences in plasma concentrations of antiseizure drugs.
Traumatic Brain Injury, Seizures, and Cognitive Impairment Among Older Adults
Authors: Zhu Yiqi , Williams Jonathan , Beyene Kebede , Trani Jean-Francois , Babulal Ganesh M. 
Published: August 2024

ImportanceTraumatic brain injury (TBI), seizures, and dementia increase with age. There is a gap in understanding the associations of TBI, seizures, and medications such as antiseizure and antipsychotics with the progression of cognitive impairment across racial and ethnic groups.ObjectiveTo investigate the association of TBI and seizures with the risk of cognitive impairment among cognitively normal older adults and the role of medications in moderating the association.Design, Setting, and ParticipantsThis multicenter cohort study was a secondary analysis of the Uniform Data Set collected between June 1, 2005, and June 30, 2020, from the National Alzheimer’s Coordination Center. Statistical analysis was performed from February 1 to April 3, 2024. Data were collected from participants from 36 Alzheimer’s Disease Research Centers in the US who were 65 years or older at baseline, cognitively normal at baseline (Clinical Dementia Rating of 0 and no impairment based on a presumptive etiologic diagnosis of AD), and had complete information on race and ethnicity, age, sex, educational level, and apolipoprotein E genotype.ExposureHealth history of TBI, seizures, or both conditions.Main Outcomes and MeasuresProgression to cognitive impairment measured by a Clinical Dementia Rating greater than 0.ResultsAmong the cohort of 7180 older adults (median age, 74 years [range, 65-102 years]; 4729 women [65.9%]), 1036 were African American or Black (14.4%), 21 were American Indian or Alaska Native (0.3%), 143 were Asian (2.0%), 332 were Hispanic (4.6%), and 5648 were non-Hispanic White (78.7%); the median educational level was 16.0 years (range, 1.0-29.0 years). After adjustment for selection basis using propensity score weighting, seizure was associated with a 40% higher risk of cognitive impairment (hazard ratio [HR], 1.40; 95% CI, 1.19-1.65), TBI with a 25% higher risk of cognitive impairment (HR, 1.25; 95% CI, 1.17-1.34), and both seizure and TBI were associated with a 57% higher risk (HR, 1.57; 95% CI, 1.23-2.01). The interaction models indicated that Hispanic participants with TBI and seizures had a higher risk of cognitive impairment compared with other racial and ethnic groups. The use of antiseizure medications (HR, 1.23; 95% CI, 0.99-1.53), antidepressants (HR, 1.32; 95% CI, 1.17-1.50), and antipsychotics (HR, 2.15; 95% CI, 1.18-3.89) was associated with a higher risk of cognitive impairment, while anxiolytic, sedative, or hypnotic use (HR, 0.88; 95% CI, 0.83-0.94) was associated with a lower risk.Conclusions and RelevanceThis study highlights the importance of addressing TBI and seizures as risk factors for cognitive impairment among older adults. Addressing the broader social determinants of health and bridging the health divide across various racial and ethnic groups are essential for the comprehensive management and prevention of dementia.
Clinician Knowledge and Attitudes About Climate Change and Health After a Quality Incentive Program
Authors: Armand Wynne , Padget Michael , Pinsky Elizabeth , Wasfy Jason H. , Slutzman Jonathan E. , Duhaime Ann-Christine 
Published: August 2024

ImportanceClimate change is a fundamental threat to human health, and industries, including health care, must assess their respective contribution to this crisis.ObjectiveTo assess the change in knowledge of clinicians who completed a quality incentive program (QIP) measure on climate change and health care sustainability and to examine clinician attitudes toward climate change and their perception of clinical and individual relevance.Design, Setting, and ParticipantsThe participants in this survey study included employed physicians and psychologists who were part of a hospital physician organization in an academic medical center (AMC) in Boston, Massachusetts. The hospital physician organization provides a QIP with different measures every 6 months and provides incentive payments on completion. The study is based on a survey of participants on completion of a QIP measure focused on climate change and health care sustainability offered from July 2023 through September 2023 at the AMC.ExposureStructured educational video modules.Main Outcomes and MeasuresAfter completion of the modules, the participants reported their baseline and postintervention knowledge on climate change impacts on health and health care sustainability, perceived relevance of the material, and attitudes toward the modules using 5-point Likert scales and free-text comments. Data were analyzed using univariate and multivariable analyses including participant age, gender, and practice specialty.ResultsOf the 2559 eligible clinicians, 2417 (94.5%) (mean [SD] age, 48.9 [11.5] years; range, 29-85 years; 1244 males [51.5%]) participated in the measure and completed the survey. Among these participants, 1767 (73.1%) thought the modules were relevant or very relevant to their lives and 1580 (65.4%) found the modules relevant or very relevant to their clinical practice. Age was not associated with responses. Practitioners in specialties classified as climate facing were more likely to think that the education was relevant to their clinical practice compared with those in non–climate-facing specialties (mean [SD] score, 3.76 [1.19] vs 3.61 [1.26]; P = .005). Practitioners identifying as female were also more likely to consider this education as relevant to their clinical practice compared with male practitioners (mean [SD] score, 3.82 [1.17] vs 3.56 [1.27]; P &amp;lt; .001).Conclusions and RelevanceIn this survey study, a high proportion of clinicians expressed positive attitudes toward education in climate change and health and health care sustainability, with some demographic and specialty variability. These data support that climate and health education in AMCs provides information that practitioners see as relevant and important.
Exploring Direct Electrochemical Fischer–Tropsch Chemistry of C1–C7 Hydrocarbons via Perimeter Engineering of Au–SrTiO3 Catalyst
Authors: Yang Ju Hyun , Sim Gi Beom , Park So Jeong , Rhee Choong Kyun , Myung Chang Woo , Sohn Youngku 
Published: August 2024

AbstractTraditionally, Fischer–Tropsch (FT) synthesis is performed using thermal catalysts and syngas (CO and H2) under high‐pressure and high‐temperature conditions. However, this study introduces an approach that relies on FT chemistry assisted by electrochemistry, referred to here as direct electrochemical (EC) FT chemistry, under ambient conditions. A series of CH4, CnH2n, and CnH2n+2 hydrocarbons (n = 1–7) is successfully produced over gold (Au) nanoparticle‐loaded perovskite strontium titanate (SrTiO3) nanostructures grown on rutile TiO2 supported on Ti. Au (1.0 nm)–SrTiO3 shows the best interface formation, with the highest Faradaic efficiency for C2+ hydrocarbons. This direct EC‐FT process proceeds via a C─C coupling chain growth reaction at the Au‐SrTiO3 interface as evidenced by the hydrocarbon weight distribution analysis and density functional theory calculations. The robust combination of experimental and computational findings reveals that optimum conditions for producing surface hydrogenation and C─C coupling polymerization, initiated by surface *CO and *H are achieved by controlling the undercoordinated Au at the perimeter sites of supported Au nanoparticles and by ensuring a harmonized density of states between Au and SrTiO3. This EC‐FT process opens a promising avenue for the direct conversion of CO2 and H2O into value‐added long‐chain hydrocarbons.