bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reservoir Outflow Prediction Using Adaptive Neuro-Fuzzy Interface System
Authors: Tatavarthi Pratyusha , Vemuri Jayaprakash , Singh Prabhakar 
Published: July 2024

Abstract

Water supply, flood control, and hydropower generation are among the primary functions that rely on the prediction of reservoir outflow. Accurate prediction of reservoir outflow can help mitigate the flood risk and ensure the long-term sustainability of the hydraulic structure. Traditional prediction methods, such as linear regression analysis, and autoregressive integrated moving average (ARIMA) models, are based on historical data from the watershed. However, due to the uncertainty involved in the prediction of trends in flood events, the use of traditional methods is considered inadequate. To overcome these limitations, machine learning (ML) algorithms such as artificial neural networks (ANNs), support vector regression (SVR), and adaptive neuro-fuzzy inference systems (ANFIS) are used. In this study, ANN and ANFIS techniques are used for predicting the daily flow at the outlet of the Godavari river basin, located in West Godavari district in the province of Andhra Pradesh, India. Three key inputs, i.e. gauge data from the rain gauge station, discharge, and elevation data were used to develop the models. Input vectors for simulations included different combinations of antecedent precipitation and flows, with different time lags. From the results, it is observed that the outflow predictions obtained using the ANFIS model are more accurate as compared to those obtained from the ANN models. Lastly, a sensitivity analysis was performed to assess the reliability and resilience of both the neural network models.
Exploring the potential value of SRC genes in pan cancer based on bioinformatics methods
Authors: Huang Liyin , Si Tao , Lu Yanwen , Yi Lei , Zhao Yuxin , Zhang Mingmin 
Published: July 2024

Abstract

Objective
The objective of this study is to investigate the expression levels of non-receptor tyrosine kinase (SRC) genes in different types of human tumor tissues, and their relationship with patient prognosis and immune microenvironment.
Methods
We utilized the Sangerbox database to analyze the differential expression of SRC in various types of cancer tumors and adjacent normal tissues. Survival outcomes of SRC expression levels in pan cancer analyzed by Cox risk ratio and Kaplan Meier analysis. We further analyzed the relationship between SRC expression and immune examination genes, tumor mutation load, microsatellite instability, and the immune microenvironment of pan cancer through the Sangerbox database.
Results
Our findings indicate that the SRC gene is highly expressed in various tumors. Furthermore, the expression level of SRC is significantly correlated with the survival outcomes of various cancers, both positively and negatively. Additionally, the results of our analyses show that the expression level of SRC is associated with tumor mutation burden, microsatellite instability, and tumor infiltration of immune cells in various cancers.
Conclusion
SRC plays a critical role in the tumor microenvironment, and is involved in the tumorigenesis and tumor immunity of various cancers. Our study suggests that SRC might be a potential prognostic biomarker and a promising therapeutic target for various cancers.
Defining ‘micromuseum’ - a Mediterranean insular curators’ perspective
Authors: Vella John 
Published: July 2024

Abstract

From a Mediterranean insular perspective, this study intends to provide a basic definition for micromuseum. The research among twenty-one micromuseums on eight Mediterranean islands was guided by a semi-structured interview with curators of independent, private, and state micromuseums on the Maltese Islands, the Ragusan Province of Sicily, and other islands for comparative reasons. All information gathered was analyzed and findings show that there are specific factors that provide for a definition of micromuseum and which differ the micromuseum from the definition applied to traditional establishment museums. Following a comparison to earlier literature on micromuseology, the study found that among others, micromuseums present specific or focused themes and collections not found in establishment museums, are rarely noticeable, have a multitasking staff, appeal to special-interest visitors, area-specialist curators, and seek high curator-visitor interactions.
Prevalence and risk factors of hyperuricemia among patients with schizophrenia in a public psychiatric hospital in China
Authors: Li Haijing , Yi Wenying , Zheng Yingjun , She Shenglin 
Published: July 2024

Abstract

Objective
Hyperuricemia (HUA) is a prevalent disease, which is associated with metabolic syndrome. It is well known that patients with schizophrenia have a high prevalence of metabolic syndrome. However, there are few studies on the HUA in patients with schizophrenia. This study aimed to investigate the prevalence of HUA and its associated risk factors in adult patients with schizophrenia.
Methods
A total of 1785 inpatients with schizophrenia ≥ 18 years were included in this retrospective study. HUA was defined as a serum uric acid > 420µmol/L in males and > 360µmol/L in females, or the self-reported diagnosis of HUA. Stepwise binary logistic regression analysis was performed to investigate the associated risk factors for HUA in patients with schizophrenia.
Results
The prevalence of HUA was 42.5% with a significant gender difference (males: 45.2% versus females: 38.9%). Compared to patients without HUA, patients with HUA were younger, had a higher prevalence of hypertension, had a higher body mass index (BMI), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL), and had a lower high-density lipoprotein cholesterol (HDL). Age, duration of schizophrenia, male gender, hypertension, BMI, TC, TG, LDL, and HDL were correlated with uric acid. Binary logistic regression analysis suggested that younger age, hypertension, BMI, TC, TG and LDL were the associated risk factors for HUA.
Conclusion
This study suggested that schizophrenia patients had a high prevalence of HUA in a Chinese psychiatric hospital. Younger age, hypertension, BMI, TC, TG and LDL were associated risk factors for HUA in patients with schizophrenia.
Adoption of Environmentally sustainable practices in rural Atacora, Benin
Authors: Onibon O. C. , Akudugu M. A. , Ayambila N. S. 
Published: July 2024

Abstract

CONTEXT
Agricultural production is paramount in developing countries driving economic development food security and environmental sustainability. Despite the importance of the later and the efforts of the Government in balancing environmental conservation with food security, the adoption of Environmentally Sustainable Practices (ESPs), remains low in Benin rural areas. This problem is a pressing challenge in the Atacora region.
OBJECTIVE
The focus of this study is rural Atacora region located in the northern part of Benin Republic. The main objective of this study was to examine the determinants of the adoption of multiple Environmentally Sustainable Practices (ESPs) and the intensity of their adoption in the study area.
METHODS
Multivariate probit and Poisson models were employed to analyze the data and examine the adoption of the Environmentally Sustainable Practices (ESPs). The EPSs considered in this research include: crop diversification, contour plowing, crop residue incorporation, composting, cover cropping, animal manure, animal traction, crop rotation.
RESULTS AND CONCLUSIONS
The findings reveal that rural households’ adoption of different ESPs and their intensity of utilization are significantly subjected various factors such as: gender of the household head,education, age, farm size, contact with extension agents as well as other households’ wealth related status. The Poisson regression model further highlight the impact of factors such as age of the household head, education, farming experience, livestock ownership, soil erosion and workshop attendance, on the intensity of multiple ESPs adoption.
SIGNIFICANCE
The study highlights the urgent need of for both the Government and various stakeholders to invest in training programs (formal and informal) aimed at boosting up the adoption of the Environmentally Sustainable Practices (ESPs) by rural dwellers. Immediate address to these enumerated factors will surely contribute at promoting environmental sustainability but also at enhancing food security status in rural areas in general and specifically in the study area which is classified among the most food insecure regions in the Republic of Benin.
Entropy-Weighted Water Quality Index Assessment of Groundwater in Ibadan Metropolis, Nigeria
Authors: ABDUS-SALAM MARYAM OLAMIDE , AKINSANYA YUSUF OLABISI , SALAMI IDRIS OLATUNDE , ADENIJI Tomiwa Williams , FALANA Adenike Omotayo , OMOTUNDE Victoria Bolaji , GBADEBO Adewole , Gbadamosi Maryam Olatundun 
Published: July 2024

Abstract

An entropy-weighted water quality index (EWQI) was used in this study to evaluate the quality of groundwater in parts of the Ibadan metropolis, Nigeria. 75 groundwater samples were collected and analysed for pH, electrical conductivity, total hardness, alkalinity, turbidity, total dissolved solids, cations (Na+, K+, Ca2+, Mg2+), anions (HCO3−, Cl−, SO42−, NO3−, F−), Fe and Total Heterotrophic Bacteria Content (THBC). The pH of the groundwater in the study area ranges from slightly alkaline to neutral. Based on the average concentrations, the abundance of anions is in the order as follows: Cl−> HCO3−> SO42−> NO3−> F− while that of cations is Na+> K+ > Ca2+ > Mg2+. The groundwater was predominantly mixed and Na-Cl hydrogeochemical facies types and was thought to be controlled by multiple processes including water-rock interaction and mineral weathering. The prevalent bacteria in this study are Klebsiella pneumonia, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The average EWQI value was 32.8, with values ranging from 2.2 to 143.6. Most of the groundwater in the research area, according to the EWQI, is good to excellent quality for drinking, while only 20% of the samples were medium to low quality, necessitating minimum treatment.
Simulation of the degradation of the main constituent from Lavandula dentata L. essential oil
Authors: Gomes Julia Novaes , Eugenio Erika de Queiros , de Almeida Márcia Rosa 
Published: July 2024

Abstract

The demand for essential oils is growing every year as an alternative to artificial additives. Lavandula dentata L. is a species of lavender that has acclimatized in Brazil and its oil has pharmacological and biological properties that give it great commercial importance. In this context, the market for essential oils has been promising and, therefore, a study into the degradation of these products interferes with the quality and biological activity of these oils, making it extremely important for their preservation. The aim of this study was to simulate the reaction equilibrium of the degradation of the main constituent from Lavandula dentata L., Lamiaceae, essential oil, 1,8-cineole (1), using the Aspen Plus® simulator v. 12 in an equilibrium reactor at a temperature of 30°C and a pressure of 1 atm. The results of the simulations indicated that ketones are the major oxidation products of 1,8-cineole when compared to the alcohols 1,3,3-trimethyl-2-oxabicyclo-[2.2.2]-octan-5-ol (2) and 1,3,3-trimethyl-2-oxabicyclo-[2.2.2]-octan-6-ol (3). In addition, the ketone 1,3,3-trimethyl-2-oxabicyclo-[2.2.2]-octan-6-one (5) was formed with a molar flow rate 1.5 times greater than the ketone 1,3,3-trimethyl-2-oxabicyclo-[2.2.2]-octan-5-one (4) due to the lower steric hindrance. Sensitivity analyses were carried out for the simulations studied, which led to the conclusion that the formation of alcohols and ketones was favored by increasing the molar oxygen flow rate. On the other hand, increasing the temperature favored the formation of ketone (5) and decreased the formation of ketone (4).
Ethnomedical knowledge of plants used in alternative medicine for the treatment of hemorrhoids in Lubumbashi, Haut-Katanga Province, Southern Democratic Republic of Congo
Authors: Valentin Bashige Chiribagula , Philippe Okusa Ndjolo , Melman Muhona , Henry Manya Mboni , Salvius Bakari Amuri , Baptiste Lumbu Simbi Jean 
Published: July 2024

Abstract

Background: A variety of medicinal plants are used in traditional medicine in Lubumbashi for the management of hemorrhoidal diseases. However, no investigation has been conducted to gather the knowledge required for this type of management in the region. The present study was conducted to inventory the plants used in Lubumbashi to treat hemorrhoidal diseases and to relate their ethnomedical characteristics.
Methods: This study was conducted between March 2022 and February 2023 using semi-structured interviews with households (n=1520), herbalists (n=25), and traditional healers : THs (n=59).
Results: The 1,604 respondents (sex ratio M/F = 0.9; mean age: 56 ± 3 years; experience: 12 ± 3 years) provided information on 100 taxa, 84 of which are used against internal hemorrhoids, Phyllanthus amarus being the most cited (Citation Index, CI: 0.76). Most of them are trees (38%) or shrubs (32%), belonging to 90 genera and 45 families dominated by the Fabaceae (10%) and Asteraceae (9%). They are indicated in 76 other pathologies, dominated by gastrointestinal disorders (GID), wounds and sexually transmitted infections (CI > 0.57). From these 100 taxa, 117 anti-hemorrhoidal formulations were derived, 11 of which combined more than one plant. In all these recipes, the leaf is the most commonly used part (>60%) and the liniment (>45%) is the most popular form of application. For the first time, this study reports 14 taxa as plants used in the treatment of hemorrhoids for which some evidence of hemorrhoidal activity has been reported. Among these taxa, Ficus stuhlmannii, Ficus laurifolia, and Ocimum centraliafricanum are listed as medicinal plants for the first time. Khaya nyasica, and Syzygium cordatum, each with 11 uses, have the highest traditional medicinal value.
Conclusion: The findings of this study indicate that a significant number of medicinal plants are used in traditional medicine in Lubumbashi for the treatment of hemorrhoidal diseases. Some of these plants are endemic to the biodiversity area, while others are shared with other cultures and regions. A series of pharmacological studies is currently underway with the objective of validating the anti-hemorrhoidal properties of these plants and in order to identify phytochemical compounds responsible of this activity.
MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and PI3K-Akt-ROS pathway.
Authors: Wang Ping , Cui Dongqing , Liu Haixia , Cao Lili , Du Xiaowei , Liu Dingxin , Liu Zhiping , Wang Tong , Yang Hui , Zheng Xiaolei , Xie Zhaohong , Xu Shunliang , Bi Jianzhong 
Published: July 2024

Abstract

Background
Alzheimer's disease (AD) stands as one of the prevalent irreversible neurodegenerative conditions marked by gradual cognitive deterioration and neuronal loss. The mammalian Ste20-like kinase (MST1)-Hippo pathway is pivotal in regulating cell apoptosis, immune response, mitochondrial function, and oxidative stress. However, the association between MST1 and mitochondrial function in AD remains unknown. Therefore, this study aims to investigate the effect of MST1 on neuronal damage and cognitive impairment by regulating mitochondrial homeostasis in AD.
Methods
In this study, we selected 4- and 7-month-old 5xFAD mice to simulate the early and middle stages of AD, we assessed cognitive function, detected neuronal damage indicators, and evaluated mitochondrial morphology, dynamics, oxidative stress, ATP, and mitochondrial apoptosis-related indicators. We employed RNA-seq technology to explore potential mechanisms of action. In vitro studies were conducted to investigate the effects of MST1 on the viability and mitochondrial function of SH-SY5Y model cells, aiming to validate the potential molecular mechanisms of MST1.
Results
Overexpression of MST1 accelerated neuronal degeneration and cognitive deficits, alongside promoting oxidative stress and mitochondrial damage. Similarly, in cell models, MST1 overexpression facilitated apoptosis and mitochondrial dysfunction. Knockdown of MST1 expression and chemical inactivation of MST1 improved cognitive decline, mitochondrial dysfunction while reducing neuronal degeneration. In terms of mechanism, MST1 was found to regulate the transcription of mitochondrial genes, including MT-Nd4L, MT-ATP6, and MT-CO2, by binding to PGC1α. It influenced cellular oxidative stress through the PI3K-Akt-ROS pathway, ultimately disrupting mitochondrial homeostasis and mediating cell damage.
Conclusion
Overall, our results showed that MST1 primarily regulates mitochondrial DNA transcription levels by interacting with PGC1α and modulates cellular oxidative stress through the PI3K-Akt-ROS pathway, thereby disrupting mitochondrial homeostasis. This discovery can potentially enhance mitochondrial energy metabolism pathways by targeting MST1, thereby offering novel potential therapeutic targets for treating AD.
Combination of rare sugars L-arabinose, D-mannose, D-xylose, D-allulose, and D-tagatose alleviates cognitive impairment in mice with type 2 diabetes mellitus
Authors: Zhang Yingying , Zhang Kun , Song Dake , Yan Tao , Ma Shanbo , Liu Ruixia , Jin Yuchen , Gong Hengxin , Yang le , Wang Xinshang , Liu Shuibing , Wang Chuan , Zhao Ming-gao 
Published: July 2024

Abstract

The objective of this study was to investigate the impact of a rare sugar complex (RSC) containing L-arabinose, D-mannose, D-xylose, D-allulose, and D-tagatose on cognitive impairment in a Type 2 diabetes (T2DM) mice model. A high-fat diet combined with streptozotocin (STZ) is commonly employed to establish a diabetes model. Behavioral performance in T2DM mice is assessed using the Morris water maze, Y maze, novel object recognition test, and novel location recognition test. Neuronal damage in the hippocampal brain area is detected through hematoxylin and eosin (HE) staining. Markers of lipid peroxidation, such as superoxide dismutase (SOD) and malondialdehyde (MDA), are measured using enzyme-linked immunosorbent assay (ELISA). The types and richness of microorganisms in the feces of each group of mice are analyzed through 16s sequencing of gut microbiota.Behavioral studies demonstrated that T2DM mice exhibited learning and memory impairments, which were notably improved with RSC administration. The SOD activity in plasma was decreased significantly, while the MDA content showed a significant increase. HE staining results revealed that RSC effectively reduced neuronal damage in the hippocampus of T2DM mice. Furthermore, RSC treatment reversed the decreased types and richness of microorganisms in the feces of T2DM mice.RSC can ameliorate cognitive dysfunction in mice with type 2 diabetes mellitus by attenuating oxidative stress in the brain and modulating the composition of intestinal microbiota.
Etiological distribution of benign ureteral stricture in 2532 adults: a cross-sectional analysis in a tertiary center
Authors: Tao Zihao , Chen Silu , Li Zhihua , Li Xinfei , Li Zhenyu , Zhang Yiming , Wang Xiang , Yang Kunlin , Guan Hua , Li Xuesong 
Published: July 2024

Abstract

Purpose: To present the etiological distribution of benign ureteral stricture (BUS) in a high-volume outpatient clinic of a tertiary center.
Methods and patients: A total of 2532 consecutive patients diagnosed with BUS were involved. The diagnosis and determination of etiology for BUS were based on a comprehensive evaluation of symptoms, medical history and imaging findings.
Results: 1307 female (51.62%) patients and 1225 male patients (48.38%) with BUS were included, with a median age of 39 years. The etiological distribution included 1130 patients (44.67%) with congenital malformations, 769 patients (30.33%) with iatrogenic injuries causes, 418 patients (16.51%) with acquired non-iatrogenic causes and 215 patients (8.49%) with unknown causes. Ureteropelvic junction obstruction (UPJO) (25.2%), urological procedures (17%), and radiotherapy (7.3%) were the most common causes of BUS. Male patients exhibited a higher prevalence of congenital malformations (49.8% vs 39.86%, P < 0.001) and a lower incidence of iatrogenic injuries (25.14% vs 35.2%, P < 0.001) compared to female patients. Congenital malformations were more common in patients < 40 years old, while iatrogenic injuries were predominant in individuals ≥ 41 years old. Patients with a history of intervention had a higher proportion of congenital malformations (P < 0.001) and a lower proportion of iatrogenic injuries (P < 0.001) and acquired factors (P< 0.001).
Conclusion: The etiology of BUS in adults was characterized by its complexity and diversity. UPJO, urologic procedure and radiotherapy were sequentially the top three causes of BUS. Age and gender significantly affected the distribution of etiologies of BUS.
Malnutrition in Hospitalized Pediatric Patients with Bronchiolitis at SantaClara University Hospital - Prevalence Study 2022
Authors: Moreno Jonathan Alexander Cutta , Pelaez Laura Roció , Baez Martha Lucia 
Published: July 2024

Abstract

Background: Malnutrition affects millions of children worldwide, despite the Sustainable Development Goals, in the year 2022, Colombia faced serious food shortages and malnutrition, especially among children under 5 years of age. According to the National Institute of Health (INS), during that year 308 children under 5 years of age died due to malnutrition and related problems. Considering this situation, it can be observed that malnutrition increases the risk of suffering from respiratory diseases. Among these diseases is acute bronchiolitis, a viral infection that mainly affects infants and is located in the lower respiratory tract.
The objective of this research is oriented to answer: What is the prevalence of acute malnutrition in patients older than 30 days and equal or younger than two years old hospitalized with bronchiolitis in the hospitalization service of Hospital Universitario Santa Clara in the months between February and July 2022?
Methodology: Cross-sectional study or prevalence study, taking as study population, patients older than 30 days and younger than 2 years of age of both sexes requiring hospital management due to bronchiolitis.
Results: From February to July 2022, a total of 183 patients were admitted to the inpatient unit of Santa Clara University Hospital due to acute bronchiolitis. Of which only 120 met the inclusion criteria proposed in the present study. It was found that 0.8% of the sample was obese, 10% overweight, 10.8% at risk of overweight, 46.7% were in an age-appropriate weight range, 23.3% at risk of acute malnutrition, 5.0% in moderate acute malnutrition, and 3.3% in severe acute malnutrition. There was a significant positive correlation between the z-score at admission and discharge of patients (R = 0.7996, p < 0.001).
Conclusions: With the development of this research work and the statistical comparisons, we concluded that those patients admitted to the hospitalization unit for acute bronchiolitis, their nutritional status at admission is very variable compared to their nutritional status at discharge, as evidenced by their z-score calculated from weight and height.