bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Prevalence of Binge Eating Disorder and Bulimia Nervosa in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Authors: Cooney Laura G , Gyorfi Kaley , Sanneh Awa , Bui Leeann M , Mousa Aya , Tay Chau Thien , Teede Helena , Stener-Victorin Elisabet , Brennan Leah 
Published: August 2024

Abstract

Context
Polycystic ovary syndrome (PCOS) is associated with disordered eating/eating disorders, but prior meta-analyses are limited by small numbers.

Objective
To inform the 2023 International PCOS Guideline, we performed a systematic review and meta-analysis evaluating the prevalence of disordered eating/eating disorders among women with and without PCOS.

Methods
Ovid MEDLINE, EMBASE, PsycInfo, and All EMB were searched from inception through February 1, 2024, for studies that compared prevalences of eating disordered/disordered eating in adolescent or adult women. Random effects meta-analyses were used to estimate the pooled odds ratios (OR) or standardized mean differences (SMD) of outcomes in women with PCOS compared to controls. Methodological quality was assessed by the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) system, and included studies were assessed for risk of bias.

Results
Of 1352 articles identified, 20 were included, with a total of 28 922 women with PCOS and 258 619 controls. Individuals with PCOS had higher odds of any eating disorder (OR: 1.53 [1.29, 1.82], 8 studies), which persisted in studies where PCOS was diagnosed by Rotterdam criteria (OR: 2.88 [1.55, 5.34], 4 studies). Odds of bulimia nervosa, binge eating disorder, and disordered eating, but not anorexia nervosa, were increased in PCOS. Mean disordered eating scores were higher in PCOS (SMD: 0.52 [0.28, 0.77], 13 studies), including when stratified by normal and higher weight body mass index. Most included studies were of moderate quality, with no evidence of publication bias.

Conclusion
Our study informs the 2023 PCOS Guideline recommendations for consideration of the risk of disordered eating/ eating disorders in care of women with PCOS, regardless of weight, especially during providing lifestyle counseling.
Association of Free Thyroxine With Progression-Free Survival in Intermediate and High-Risk Differentiated Thyroid Cancer
Authors: Ghosh Raisa , Auh Sungyoung , Gubbi Sriram , Veeraraghavan Padmasree , Cochran Craig , Shobab Leila , Urken Mark L , Burman Kenneth D , Wartofsky Leonard , Klubo-Gwiezdzinska Joanna 
Published: August 2024

Abstract

Context
Supraphysiologic T4 doses are used in intermediate- and high-risk patients with differentiated thyroid cancer (IR/HR-DTC) to suppress tumor progression by TSH. However, preclinical data suggest that T4 can also act as a growth stimulus for cancer, but there is no clinical evidence supporting this claim.

Objective
We analyzed the association between free T4 (FT4) and progression-free survival (PFS) in patients with IR/HR-DTC.

Methods
This longitudinal cohort study, approved by multi-institutional review board, included patients with IR/HR-DTC treated uniformly with total thyroidectomy, radioiodine, and TSH suppression therapy, with at least 3 TSH and FT4 values available. Association between FT4 and PFS at landmarks 6, 12, and 18 months was assessed by Kaplan-Meier survival curves, whereas competing risks were assessed through Cox proportional hazards model.

Results
From 739 screened patients, 382 met the inclusion criteria and were characterized by a median age of 46 (34-59) years, 64.1% women, and treated with a median radioiodine dosage of 159 (110-410) mCi. During follow up of 7.1 (3.4-12.7) years, 34.6% experienced disease progression. Elevated FT4, observed in 29.3% of patients, was not associated with worse PFS (hazard ratio [HR], 0.9; CI, 0.54-1.5; P = .69), whereas age (HR, 1.02; CI, 1.004-1.04; P = .01), tumor size (HR, 1.15; CI, 1.04-1.28; P = .01) and metastases to the lateral neck lymph nodes (HR, 2.9; CI, 1.7-4.74; P &lt; .001), bones (HR, 4.87; CI, 1.79-13.3; P = .002), and brain (HR, 5.56; CI; 2.54-12.2; P &lt; .001) were associated with shorter PFS.

Conclusion
Contrary to preclinical evidence, elevated FT4 levels do not affect PFS in patients with IR/HR-DTC.
Effect of In Vivo Administration of Fibrinogen Concentrate Versus Cryoprecipitate on Ex Vivo Clot Degradation in Neonates Undergoing Cardiac Surgery
Authors: Downey Laura A. , Moiseiwitsch Nina , Nellenbach Kimberly , Xiang Yijin , Brown Ashley C. , Guzzetta Nina A. 
Published: August 2024

BACKGROUND:
Neonates undergoing cardiac surgery require fibrinogen replacement to restore hemostasis after cardiopulmonary bypass (CPB). Cryoprecipitate is often the first-line treatment, but recent studies demonstrate that fibrinogen concentrate (RiaSTAP; CSL Behring) may be acceptable in this population. This investigator-initiated, randomized trial compares cryoprecipitate to fibrinogen concentrate in neonates undergoing cardiac surgery (ClinicalTrials.gov NCT03932240). The primary end point was the percent change in ex vivo clot degradation from baseline at 24 hours after surgery between groups. Secondary outcomes included intraoperative blood transfusions, coagulation factor levels, and adverse events.

METHODS:
Neonates were randomized to receive cryoprecipitate (control group) or fibrinogen concentrate (study group) as part of a post-CPB transfusion algorithm. Blood samples were drawn at 4 time points: presurgery (T1), after treatment (T2), arrival to the intensive care unit (ICU) (T3), and 24 hours postsurgery (T4). Using the mixed-effect models, we analyzed the percent change in ex vivo clot degradation from a patient’s presurgery baseline at each time point. Intraoperative blood product transfusions, coagulation factor levels, perioperative laboratory values, and adverse events were collected.

RESULTS:
Thirty-six neonates were enrolled (intent to treat [ITT]). Thirteen patients in the control group and seventeen patients in the study group completed the study per protocol (PP). After normalizing to the patient’s own baseline (T1), no significant differences were observed in clot degradation at T2 or T3. At T4, patients in the study group had greater degradation when compared to those in the control group (826.5%, 95% confidence interval [CI], 291.1–1361.9 vs −545.9%, 95% CI, −1081.3 to −10.4; P < .001). Study group patients received significantly less median post-CPB transfusions than control group patients (ITT, 27.2 mL/kg [19.0–36.9] vs 41.6 [29.2–52.4]; P = .043; PP 26.7 mL/kg [18.8–32.2] vs 41.2 mL/kg [29.0–51.4]; P < .001). No differences were observed in bleeding or thrombotic events.

CONCLUSIONS:
Neonates who received fibrinogen concentrate, as compared to cryoprecipitate, have similar perioperative ex vivo clot degradation with faster degradation at 24 hours postsurgery, less post-CPB blood transfusions, and no increased bleeding or thrombotic complications. Our findings suggest that fibrinogen concentrate adequately restores hemostasis and reduces transfusions in neonates after CPB without increased bleeding or thrombosis risk.
Mismatched: Intensive Mothering in China's Urban Villages
Authors: Jin Shuheng , Dai Haijing 
Published: August 2024

Abstract
As the PRC is woven ever more tightly into transnational circuits of culture and capital, Chinese working-class subjectivities—like middle-class ones, but also distinctively—become (re)produced through increasingly transnational processes. This includes the new reach of global discourses like intensive mothering into China’ s migrant-worker population. Intensive mothering has long been learned as the dominant culture of motherhood in North America. Along with other products and ideas, this ideology of intensive mothering is imported to China’ s new generation of mothers, supported by the state’ s emphasis on scientific child-rearing and the social media boom. Euro-American middle-class mothers, depicted as ideal mothers who abide by expert knowledge and cultivate their children’ s talent accordingly, are represented as counterexamples to traditional Chinese mothers in mass media. Migrant mothers in the urban villages of China have learned and internalized this ideology of intensive mothering along with their rural-to-urban migration through reading and interactions with medical and educational experts. Based on eight months of ethnographic research in two urban villages in southern China, this article presents research into how migrant mothers become trapped in the mismatches between the Euro-American, urban middle-class ideology of intensive mothering and their own position in the social class hierarchy. With limited economic and cultural resources, learning and internalizing intensive mothering disempowers migrant mothers and makes them feel even less competent. In response, they find other alternatives to reassert their agency.
The Sinophone as an Uneven Experience of Time and Place: Translocal Media Consumption in Chinese-Speaking Malaysia
Authors: Yu Ting-Fai 
Published: August 2024

Abstract
Based on interviews and ethnographic engagement with Malaysian consumers of post-1990s Chinese-language popular media products (television, film, and music), this article argues that overseas Chinese identity formation may be as much a translocal as a transnational phenomenon. Specifically, it demonstrates how Chinese-speaking Malaysia has been unevenly affected by Sinophone media flows across generations and regions, resulting in divergent cultural practices and aspirations, and it highlights intraethnic complexities that are determined by both temporal and spatial contexts. First, it examines Chinese Malaysians’ consumption of Chinese-language media as an intergenerational experience, vis-à-vis the general shift from the popularity of Hong Kong media before 2000, toward media from the People’s Republic of China in the present. Second, by highlighting the unique position of Johor, the Malaysian state bordering Singapore, in the Sinophone media circuit, the article demonstrates how in some cases geographic proximities may be more significant than national boundaries or policies in regulating cultural traffic. Finally, in the age of global China, this article highlights how interviewees’ present consumption of non-PRC Chinese-language media exemplifies a Sinophone logic of cultural and affective mobilities that resists the homogenization of PRC media in Southeast Asia. As an attempt to engage theorizations of translocality and transnationality in productive tension with each other, the article concludes by arguing for the significance of Malaysia in highlighting Sinophone cultures as uneven experiences of time and space.
A multi-layered integrative analysis reveals a cholesterol metabolic program in outer radial glia with implications for human brain evolution
Authors: Moriano Juan , Leonardi Oliviero , Vitriolo Alessandro , Testa Giuseppe , Boeckx Cedric 
Published: August 2024

ABSTRACTThe definition of molecular and cellular mechanisms contributing to brain ontogenetic trajectories is essential to investigate the evolution of our species. Yet their functional dissection at an appropriate level of granularity remains challenging. Capitalizing on recent efforts that have extensively profiled neural stem cells from the developing human cortex, we develop an integrative computational framework to perform trajectory inference and gene regulatory network reconstruction, (pseudo)time-informed non-negative matrix factorization for learning the dynamics of gene expression programs, and paleogenomic analysis for a higher-resolution mapping of derived regulatory variants in our species in comparison with our closest relatives. We provide evidence for cell type-specific regulation of gene expression programs during indirect neurogenesis. In particular, our analysis uncovers a key role for a cholesterol program in outer radial glia, regulated by zinc-finger transcription factor KLF6. A cartography of the regulatory landscape impacted by Homo sapiens-derived variants reveals signals of selection clustering around regulatory regions associated with GLI3, a well-known regulator of radial glial cell cycle, and impacting KLF6 regulation. Our study contributes to the evidence of significant changes in metabolic pathways in recent human brain evolution.
Change in Biomarker Profile After Neoadjuvant Chemotherapy is Prognostic and Common Among Patients with HER2+ Breast Cancer
Authors: Tchou Julia , Gottipati Soumy , Goldbach Macy , Baxter Molly , Venters Sara , Balassanian Ron , Vohra Poonam , Gonzalves Diego , Ahmad Zahra , Nayak Anupma , Boughey Judy C. , Mukhtar Rita A. , Chen Yunn-Yi 
Published: August 2024

Abstract
Background
Rates of pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) for breast cancer have improved, especially among human epidermal growth factor 2-positive (HER2+) and triple-negative subtypes. The frequency and significance of biomarker profile change in residual disease are unclear. This study aimed to determine the rate of biomarker profile changes after NAC and the impact on clinical outcomes in a contemporary cohort.

Methods
Upon institutional review board approval, the study identified 634 consecutive patients treated with NAC between 2010 and 2022 at two academic institutions. The study cohort was focused on patients with residual disease who underwent biomarker profile retesting. Biomarker profile change for each subtype was compared across groups using Fisher-Irwin tests. Cox Proportional Hazards Model and Kaplan-Meier plots were performed to evaluate the association of changed versus unchanged biomarker profile with event-free survival.

Results
Biomarker retesting was performed for 259 (61.4 %) of 422 patients with residual disease. Biomarker profile change occurred in 18.1 % overall and was significantly higher among those with pre-NAC HER2+ disease (32.7 %, 17/52) than among those with HER2–disease (14.5 %, 30/207) (p = 0.004). Conversion of pre-NAC biomarker profiles of HR+HER2– and HR+HER2+ to triple-negative breast cancer (TNBC) post-NAC may be associated with worse event-free survival, hazard ratios of 2.23 (95 % confidence interval [CI], 0.90–5.53; p = 0.08), trending toward significance, and 36.7 (95 % CI, 2.2–610.8; p = 0.01), respectively.

Conclusions
The results from one of the largest contemporary cohorts demonstrated that biomarker profile change in patients with residual disease after NAC was common. Furthermore, specific biomarker profile change in residual disease may have prognostic value. These findings strengthen the rationale for routine re-testing of biomarkers in residual disease after NAC.
Sub-area design of a reflective metasurface for Bessel beam generation to mitigate the impact of feed occlusion
Authors: Hao Honggang , Zhang Ting , Yin Dan , He Jinfeng 
Published: August 2024

This paper introduces a sub-area metasurface designed to mitigate the effects of feed occlusion when generating Bessel beams on reflective metasurfaces. This unit incorporates an anisotropic structure with distinct phase responses tailored for two orthogonal linearly polarized (LP) electromagnetic (EM) waves. The energy loss of the Bessel beam, situated behind the feed source, generated by the outer ring, is minimized through the superposition of the inward traveling waves and strategic partitioning of the array area. Furthermore, the principle of electric field superposition is employed to focus on the inner ring. The simulated results demonstrate that at 9 GHz, the metasurface produces a bifocal effect with focusing efficiencies of 60.1% and 64.3%, in conjunction with a Bessel beam exhibiting a diffraction-free region of 799 mm. For x polarization, the full width at half-maximum (FWHM) of the post-feed Bessel beam is 49.83 mm (1.49λ). In contrast, under y polarization, the FWHM of the Bessel beam with an off-axis angle of 30° is 47.63 mm (1.43λ). The simulated results suggest that the proposed metasurface has promising applications in point-to-multipoint or same-path multi-target wireless power transmission (WPT) systems.
Flexible-queue-management-based bandwidth allocation in higher-speed PONs
Authors: Li Jun , Sun Guanlun , Lu Xiang , Lin Rui , Wosinska Lena 
Published: August 2024

Higher-speed passive optical networks (i.e., ITU-T 50G PONs) are envisioned to support various time-sensitive services with diverse quality of service (QoS) requirements (e.g., latency and jitter). To achieve this goal, higher-speed PON introduces multiple queues in each transmission container (T-CONT) so that each queue can carry a type of time-sensitive traffic. However, in the existing dynamic bandwidth allocation (DBA) schemes, the DBA engine in the optical line terminal (OLT) allocates bandwidth to four types of T-CONTs based on their buffer occupancies and priorities without considering queue status (e.g., the amount of data frames in queues) and services’ QoS requirements. To support multiple services belonging to the same T-CONT, the traffic scheduler in each optical network unit (ONU) further assigns the bandwidth of T-CONTs to their associated queues by using priority-based scheduling strategies. In this way, the bandwidth is allocated to queues by the DBA engine and traffic scheduler independently, which cannot guarantee network performance and meet the stringent QoS requirements of time-sensitive services. To solve this problem, we propose a DBA mechanism based on flexible queue management (FQM) to enable direct allocation of bandwidth to the queues under their QoS requirements. The proposed FQM mechanism enables the DBA engine to obtain the arrival time and QoS requirements of data frames in different queues as well as queue status based on the existing report/grant mechanism. By using these parameters, the required bandwidth for each queue in the next polling cycle can be calculated. Then, the DBA engine allocates bandwidth to these queues according to their bandwidth requests and priorities periodically. Simulation results show that the proposed scheme outperforms two benchmarks in the aspects of meeting time-sensitive services’ diverse QoS requirements, even when the traffic load is high.
Impact of the Ge-Si interfacial barrier on the temperature-dependent performance of PureGaB Ge-on-Si p + n photodiodes
Authors: Marković Lovro , Knežević Tihomir , Nanver Lis K. , Attariabad Asma , Azizur-Rahman Khalifa M. , Mah Jasmine J. , Wang Kang L. , Suligoj Tomislav 
Published: August 2024

A temperature-dependent study of the near-infrared (NIR) responsivity of Ge-on-Si photodiodes is presented. The diodes, formed as n-Ge islands within oxide windows on n-Si and capped with Ga and B layers (PureGaB), exhibit low dark current of ∼2 × 10−13 A/µm2 and broadband responsivity. Temperature-dependent measurements reveal an inherent potential barrier at the low-doped n-Ge on the n-Si heterointerface. This leads to a decrease in responsivity with decreasing temperatures for wavelengths above 1100 nm. The Al-migration process along the Ge-Si interface, associated with the sidewall passivation and found to be a means of reducing dark current, increases the barrier height. Irrespective of the barrier height, room-temperature responsivity is fully recovered by applying a reverse bias to lower the interface barrier. In the devices with the highest barrier, the responsivity at 1310 nm increased from 4.8 to 164 mA/W, at 0 V and 18 V reverse bias, respectively. An additional increase in maximum responsivity at 1550 nm is attributed to Al-sidewall passivation leading to a measured responsivity of 126.4 mA/W at 18 V reverse bias.
Identification of unmet palliative care needs of nursing home residents: A scoping review protocol
Authors: Crowley Patrice , Saab Mohamad M. , Cornally Nicola , Ronan Isabel , Tabirca Sabin , Murphy David 
Published: August 2024

Introduction
Nursing home residents often have life limiting illnesses in combination with multiple comorbidities, cognitive deficits, and frailty. Due to these complex characteristics, a high proportion of nursing home residents require palliative care. However, many do not receive palliative care relative to this need resulting in unmet care needs. To the best of our knowledge, there have been no literature reviews to synthesise the evidence on how nursing home staff identify unmet palliative care needs and to determine what guidelines, policies, and frameworks on identifying unmet palliative care needs of nursing home residents are available.

Aim
The aim of this scoping review is to map and summarise the evidence on identifying unmet palliative care needs of residents in nursing homes.

Methods
This scoping review will be guided by the JBI Manual for Evidence Synthesis. The search will be conducted in CINAHL, MEDLINE, Embase, Web of Science, APA PsycINFO, and APA PsycArticles. A search of grey literature will also be conducted in databases such as CareSearch, Trip, GuidelineCentral, ClinicalTrials.gov, and the National Institute for Health and Care and Excellence website. The search strategy will be developed in conjunction with an academic librarian. Piloting of the screening process will be conducted to ensure agreement among the team on the eligibility criteria. Covidence software will be used to facilitate deduplication, screening, and blind reviewing. Four reviewers will conduct title and abstract screening. Six reviewers will conduct full text screening. Any conflicts will be resolved by a reviewer not involved in the conflict. One reviewer will conduct data extraction using pre-established data extraction tables. Results will be synthesised, and a narrative synthesis will be used to illustrate the findings of this review. Data will be presented visually using tables, figures, and word clouds, as appropriate.
Patients’ experiences with musculoskeletal spinal pain: A qualitative systematic review protocol
Authors: El Chamaa Alaa , Kowalski Katie , Parikh Pulak , Rushton Alison 
Published: August 2024

Background
Musculoskeletal (MSK) spinal pain encapsulates various conditions including lumbar (low back), cervical (neck), and thoracic pain that significantly impact individual and global health. While clinical aspects of spinal pain have been well-studied, understanding patients’ personal narratives and lived experiences remains essential for enhancing patient-centered care, improving treatment adherence, and informing healthcare policies. It provides deep insights into the impacts of spinal pain, guiding more effective and empathetic treatment approaches. This systematic review aims to synthesize qualitative evidence on patients’ experiences with MSK spinal pain, providing insight into the challenges faced, coping strategies, daily life impacts, and healthcare interactions. The objective of this review is to synthesize the qualitative evidence regarding the lived experiences of patients with MSK spinal pain.

Methods
This systematic review will use a meta-aggregation approach to synthesize data from qualitative studies, that will be identified through a comprehensive search of electronic databases and supplemented by grey literature searches. Two independent reviewers will screen, identify, and extract data from eligible studies. In cases of disagreement, conflicts will be resolved by consulting a third reviewer. These same reviewers will then use the Joanna Briggs Institute (JBI) qualitative quality assessment tool to evaluate the methodological quality of the identified studies, with the derived scores informing the synthesis process, that will involve extracting each study’s findings along with their supporting illustrations, then grouped into categories based on similarity in meaning. These categories will then be aggregated to form synthesized findings.

Implications
Synthesized findings on patients’ lived experiences with MSK spinal pain including key themes, patterns, and insights will be presented. By emphasizing patient narratives, the results of the review can contribute to the optimization of outcomes, and to enhance patient-provider relations and improve quality of care in MSK spinal health.