bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of patient photographs and reduced retract-and-reorder events
Authors: Rzewnicki Daniel , Kanvinde Atul , Gillespie Scott , Orenstein Evan 
Published: July 2024

Abstract

Background
Wrong-patient order entry (WPOE) is a potentially dangerous medical error. It remains unknown if patient photographs reduce WPOE in the pediatric inpatient population.

Materials and Methods
Order sessions from a single pediatric hospital system were examined for retract-and-reorder (RAR) events, a surrogate WPOE measure. We determined the association of patient photographs with the proportion of order sessions resulting in a RAR event, adjusted for patient, provider, and ordering context.

Results
In multivariable analysis, the presence of a patient photo in the electronic health record was associated with 40% lower odds of a RAR event (aOR: 0.60, 95% CI: 0.48-0.75), while cardiac and ICU contexts had higher RAR frequency (aOR: 2.12, 95% CI: 1.69-2.67 and 2.05, 95% CI: 1.71-2.45, respectively).

Discussion and Conclusion
Patient photos were associated with lower odds of RAR events in the pediatric inpatient setting, while high acuity locations may be at higher risk. Patient photographs may reduce WPOE without interruptions.
Exploring plant adaptation strategies to phosphorus limitation induced by nitrogen addition: foliar phosphorus allocation and root functional traits analysis in two dominant subalpine tree species
Authors: Su Yan , Tang Yongfeng , Hu Yi , Liu Meiyu , Lu Xuyang , Duan Baoli 
Published: July 2024

Abstract
Plants adapt to the limitation of soil phosphorus (P) induced by nitrogen (N) deposition through a complex interaction of various root and leaf functional traits. In this study, a pot experiment was conducted to explore the effects of different levels of N addition (control, low N [LN]: 25 kg N ha−1 yr−1, high N [HN]: 50 kg N ha−1 yr−1) on tree growth, leaf nutrient content, foliar P fractions and root characteristics of two dominant tree species, the pioneer species Salix rehderiana Schneid and the climax species Abies fabri (Mast.) Craib, in a subalpine forest in southwestern China. The results demonstrated that LN addition had a minimal impact on leaf N and P contents. Conversely, HN addition significantly decreased the leaf P content in both species. Salix rehderiana exhibited more pronounced increases in specific root length and specific root area under P deficiency triggered by HN addition when compared with A. fabri. In contrast, A. fabri showed weaker morphological responses to N addition but had a higher proportion of foliar P to metabolic P, as well as higher root exudates rate and root phosphatase activity in response to HN addition. Abies fabri employs a synergistic approach by allocating a greater amount of leaf P to metabolite P and extracting P from the soil through P-mobilizing exudates and root phosphatase activity, while S. rehderiana exhibits higher flexibility in modifying its root morphology in response to P limitation induced by HN addition. This study provides insights into subalpine tree species adaptation to N-induced P limitation, emphasizing its significance for guiding forest management and conservation in the context of global climate change.
Epidemiology of travel-associated dengue from 2007 to 2022: A GeoSentinel analysis
Authors: Duvignaud Alexandre , Stoney Rhett J , Angelo Kristina M , Chen Lin H , Cattaneo Paolo , Motta Leonardo , Gobbi Federico G , Bottieau Emmanuel , Bourque Daniel L , Popescu Corneliu P , Glans Hedvig , Asgeirsson Hilmir , Oliveira-Souto Ines , Vaughan Stephen D , Amatya Bhawana , Norman Francesca F , Waggoner Jesse , Díaz-Menéndez Marta , Beadsworth Michael , Odolini Silvia , Camprubí-Ferrer Daniel , Epelboin Loic , Connor Bradley A , Eperon Gilles , Schwartz Eli , Libman Michael , Malvy Denis , Hamer Davidson H , Huits Ralph ,   for the GeoSentinel Network
Published: July 2024

Abstract

Background
Dengue is a leading cause of febrile illness among international travellers. We aimed to describe the epidemiology and clinical characteristics of imported dengue in returning travellers evaluated at GeoSentinel sites from 2007 to 2022.

Methods
We retrieved GeoSentinel records of dengue among travellers residing in non-endemic countries. We considered dengue confirmed when diagnosed by a positive dengue virus (DENV)–specific reverse-transcriptase polymerase chain reaction, positive NS-1 antigen and/or anti-DENV IgG seroconversion, and probable when diagnosed by single anti-DENV IgM or high-titre anti-DENV IgG detection. Severe dengue was defined as evidence of clinically significant plasma leakage or bleeding, organ failure, or shock, according to the 2009 World Health Organization guidance. Complicated dengue was defined as either severe dengue or dengue with presence of any warning sign. Analyses were descriptive.

Results
This analysis included 5958 travellers with confirmed (n = 4859; 81.6%) or probable (n = 1099; 18.4%) dengue. The median age was 33 years (range: &lt;1–91); 3007 (50.5%) travellers were female. The median travel duration was 21 days (interquartile range [IQR]: 15–32). The median time between illness onset and GeoSentinel site visit was 7 days (IQR: 4–15). The most frequent reasons for travel were tourism (67.3%), visiting friends or relatives (12.2%) and business (11.0%). The most frequent regions of acquisition were South East Asia (50.4%), South Central Asia (14.9%), the Caribbean (10.9%) and South America (9.2%). Ninety-five (1.6%) travellers had complicated dengue, of whom 27 (0.5%) had severe dengue and one died. Of 2710 travellers with data available, 724 (26.7%) were hospitalized. The largest number of cases (n = 835) was reported in 2019.

Conclusions
A broad range of international travellers should be aware of the risk of acquiring dengue and receive appropriate pre-travel counselling regarding preventive measures. Prospective cohort studies are needed to further elucidate dengue risk by destination and over time, as well as severe outcomes and prolonged morbidity (long dengue) due to travel-related dengue.
Contrapuntal Parody and Transsymphonic Narrative in Mahler’s Rondo-Burleske
Authors: Reenan Sam 
Published: July 2024

Abstract
This article deconstructs the intersections of form, counterpoint, and narrative that contribute to parody in the third movement Rondo-Burleske of Gustav Mahler’s Ninth Symphony. Motivic counterpoint problematizes the movement’s main rondo theme, placing initial cracks in the movement’s rondo façade. Through thematic and formal counterpoint, the rondo genre itself destabilizes as signifiers of sonata-form rhetoric intrude. To interpret how counterpoint and generic mixture contribute to the burlesque character of the movement, I consider theoretical accounts of parody and the burlesque, and I adapt, as a generative metaphor, Mikhail Bakhtin’s notion of the carnivalesque. In the context of the Ninth Symphony’s transsymphonic narrative, the Rondo-Burleske performs a carnival parody of the symphonic finale genre, functioning as a brazen, iconoclastic, but in the end, failed counterpart to the first movement.
Computational identification of ultra-conserved elements in the human genome: a hypothesis on homologous DNA pairing
Authors: Crossley Emily R , Fedorova Larisa , Mulyar Oleh A , Freeman Ryan , Khuder Sadik , Fedorov Alexei 
Published: July 2024

Abstract
Thousands of prolonged sequences of human ultra-conserved non-coding elements (UCNEs) share only one common feature: peculiarities in the unique composition of their dinucleotides. Here we investigate whether the numerous weak signals emanating from these dinucleotide arrangements can be used for computational identification of UCNEs within the human genome. For this purpose, we analyzed 4272 UCNE sequences, encompassing 1 393 448 nucleotides, alongside equally sized control samples of randomly selected human genomic sequences. Our research identified nine different features of dinucleotide arrangements that enable differentiation of UCNEs from the rest of the genome. We employed these nine features, implementing three Machine Learning techniques – Support Vector Machine, Random Forest, and Artificial Neural Networks – to classify UCNEs, achieving an accuracy rate of 82–84%, with specific conditions allowing for over 90% accuracy. Notably, the strongest feature for UCNE identification was the frequency ratio between GpC dinucleotides and the sum of GpG and CpC dinucleotides. Additionally, we investigated the entire pool of 31 046 SNPs located within UCNEs for their representation in the ClinVar database, which catalogs human SNPs with known phenotypic effects. The presence of UCNE-associated SNPs in ClinVar aligns with the expectation of a random distribution, emphasizing the enigmatic nature of UCNE phenotypic manifestation.
ENT3C: an entropy-based similarity measure for Hi-C and micro-C derived contact matrices
Authors: Lainscsek Xenia , Taher Leila 
Published: July 2024

Abstract
Hi-C and micro-C sequencing have shed light on the profound importance of 3D genome organization in cellular function by probing 3D contact frequencies across the linear genome. The resulting contact matrices are extremely sparse and susceptible to technical- and sequence-based biases, making their comparison challenging. The development of reliable, robust and efficient methods for quantifying similarity between contact matrices is crucial for investigating variations in the 3D genome organization in different cell types or under different conditions, as well as evaluating experimental reproducibility. We present a novel method, ENT3C, which measures the change in pattern complexity in the vicinity of contact matrix diagonals to quantify their similarity. ENT3C provides a robust, user-friendly Hi-C or micro-C contact matrix similarity metric and a characteristic entropy signal that can be used to gain detailed biological insights into 3D genome organization.
Adherence to Mediterranean Diet and Health Outcomes in Adolescents: An Umbrella Review
Authors: Di Nucci Annalisa , Silano Marco , Cardamone Erica 
Published: July 2024

Abstract

Context
Proper nutrition represents 1 of the domains of adolescents' well-being. In this context, the Mediterranean diet (MD), as a healthy, traditional, and sustainable dietary pattern, plays a crucial role in promoting adequate growth and preventing chronic noncommunicable diseases.

Objective
The currently available evidence on the effects of adherence to the MD (AMD) in association with several physical health outcomes in adolescence is summarized in this review.

Data Sources
Five electronic databases were searched.

Study Selection
Systematic reviews with or without meta-analysis of observational studies and randomized clinical trials, published in English during 2013–2022, and that assessed the health impact of AMD among adolescents were eligible.

Data Extraction
Details on study design, methods, population, assessment of dietary patterns, health outcomes, and main results were extracted.

Results
The search yielded 59 references after removal of duplicates. Applying PICOS criteria, 4 systematic reviews and 3 meta-analyses ultimately were included in this review. The AMD was evaluated in association with overweight/obesity and adiposity in 2 studies, musculoskeletal health in another 2, inflammation in 1 study, and cardiometabolic health in 1 study. The seventh review examined all mentioned health outcomes (overweight and obesity, musculoskeletal health, inflammation, and cardiometabolic health) in relation to AMD.

Conclusions
Overall, this umbrella review showed limited evidence and a lack of consistency about the relation between AMD and health outcomes of interest in adolescence, indicating the need for more studies to better understand it.

Systemic Review Registration
PROSPERO registration no. CRD42023428712.
Neuroretinal Alterations in Schizophrenia and Bipolar Disorder: An Updated Meta-analysis
Authors: Sheehan Nora , Bannai Deepthi , Silverstein Steven M , Lizano Paulo 
Published: July 2024

Abstract
Schizophrenia (SZ) and bipolar disorder (BD) are characterized by major symptomatic, cognitive, and neuroanatomical changes. Recent studies have used optical coherence tomography (OCT) to investigate retinal changes in SZ and BD, but their unique and shared changes require further evaluation. Articles were identified using PubMed and Google Scholar. 39 studies met the inclusion criteria. Diagnostic groups were proband (SZ/BD combined), SZ, BD, and healthy control (HC) eyes. Meta-analyses utilized fixed and random effects models when appropriate, and publication bias was corrected using trim-and-fill analysis (“meta” package in R). Results are reported as standardized mean differences with 95% CIs. Data from 3145 patient eyes (1956 SZ, 1189 BD) and 3135 HC eyes were included. Studies identified thinning of the peripapillary retinal nerve fiber layer (pRNFL, overall and in 2 subregions), m-Retina (overall and all subregions), mGCL-IPL, mIPL, and mRPE in SZ patients. BD showed thinning of the pRNFL (overall and in each subregion), pGCC, and macular Retina (in 5 subregions), but no changes in thickness or volume for the total retina. Neither SZ nor BD patients demonstrated significant changes in the fovea, mRNFL, mGCL, mGCC, mINL, mOPL, mONL, or choroid thicknesses. Moderating effects of age, illness duration, and smoking on retinal structures were identified. This meta-analysis builds upon previous literature in this field by incorporating recent OCT studies and examining both peripapillary and macular retinal regions with respect to psychotic disorders. Overall, this meta-analysis demonstrated both peripapillary and macular structural retinal abnormalities in people with SZ or BD compared with HCs.
Health risk and germ cell toxicity of five commercially available sachet waters in Nigeria: a public health concern
Authors: Alabi Okunola Adenrele , Lawrence Olufunbi Esther , Ayeni Funmilayo Esther , Olumurewa John A V 
Published: July 2024

Abstract

Background
Sachet water is the most common form of portable water commercially available in Nigeria.

Methodology
Using the murine sperm count and sperm abnormality assay, the germ cell toxicity of five common commercially available sachet waters in Nigeria was assessed in this study. The levels of hormones such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Total Testosterone (TT); and activities of catalase (CAT), alanine aminotransferase (ALT), superoxide dismutase (SOD), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were evaluated. The heavy metal and physicochemical parameters of the sachet waters were also analyzed. Healthy male mice were allowed to freely drink the sachet waters for 35 days after which they were sacrificed.

Results
The findings indicated that the concentrations of some heavy metals (As, Cr, and Cd) in the sachet waters exceeded the limit by regulatory organizations. The data of the total carcinogenic risk (TCR) and total non-carcinogenic risk (THQ) of some heavy metals associated with the ingestion of sachet water for adults and children showed that the values exceeded the acceptable threshold, and thus, is indicative of a high non-carcinogenic and carcinogenic risks. The data of the sperm abnormality assay showed that in the exposed mice, the five sachet waters induced a statistically significant (P &lt; 0.05) increase in abnormal sperm cells and a significantly lower mean sperm count. Additionally noted were changes in the serum activities of TT, FSH, ALP, AST, ALT, and LH.

Conclusion
Thus, the sachet waters studied contained agents that can induce reproductive toxicity in exposed humans. This is of public health importance and calls for immediate action by regulatory bodies.
High endemic freshwater mussel (Bivalvia: Unionida) diversity in western Borneo, with description of three new species
Authors: Zieritz Alexandra , Pfeiffer John , Rahim Khairul Adha A , Prayogo Hari , Anwari Muhammad Sofwan , Diba Farah , Froufe Elsa , Blackwell Tabitha , Hartikainen Hanna , Lopes-Lima Manuel 
Published: July 2024

Abstract
The freshwater mussels (Bivalvia: Unionida) of the biodiversity hotspot Sundaland are experiencing severe anthropogenic threats, whilst their diversity and distribution remain poorly understood. Here, we present the first modern-day data on Unionida diversity and distribution across western Borneo. Mussels were surveyed and collected in the upper Kapuas and Pawan river basins in West Kalimantan, Indonesia, and the Sambas Besar, Sarawak and Batang Sadong river basins in Sarawak, Malaysia. DNA sequencing (COI + 16S + ND1 + 18S + 28S) and morphological analyses were conducted to delineate and identify species, and reconstruct phylogenetic relationships and population genetics. Specimens belonged to six native genera and nine species, of which seven are endemic to Borneo and three are new to science, i.e. Ctenodesma mawonae Zieritz et al., sp. nov., Sarawak basin, and Ctenodesma bersinara Zieritz et al., sp. nov., and Rectidens lauris Zieritz et al., sp. nov., both Pawan basin. The monotypic genera Caudiculatus and Discomya were phylogenetically highly divergent from other known Gonideinae taxa, potentially indicating a separate tribe (for Caudiculatus) and subfamily (for Discomya). In addition, we report new records of the non-native Sinanodonta pacifica Heude, 1878 in the Batang Sadong and Kapuas river basins.
The Development and Characteristics of Planetary Health in Medical Education: A Scoping Review
Authors: Visser Eva H. , Oosterveld Berdien , Slootweg Irene A. , Vos Hedwig M.M. , Adriaanse Marieke A. , Schoones Jan W. , Brakema Evelyn A. 
Published: July 2024

Abstract

Purpose
Climate change, biodiversity loss, and other ecological crises threaten human health globally. The interrelation between human health and ecosystems is addressed in the emerging field of planetary health. Ecological crises have created an urgency to integrate planetary health, including sustainable health care, into medical education. To facilitate integration and guide future research, this review aims to provide an overview of the existing literature about planetary health in medical education.

Method
The authors conducted a scoping review using the conventional methodological framework for scoping studies. They performed a comprehensive search in 7 databases without language restrictions in March 2022. Two researchers independently extracted data. The team analyzed the data using data-driven thematic analysis, content analysis, and qualitative summarizing. Data were structured according to the Curriculum Development for Medical Education: A Six-Step Approach.

Results
The authors identified 3,703 unique publications, of which 127 were included. Articles predominantly (71%, n = 90) covered the call to integrate planetary health in medical education (step 1: general needs assessment). Many publications (24%, n = 31) proposed learning objectives (step 3); these mainly concerned raising awareness, while few concerned action perspectives. Publications limitedly reported on the final steps of curriculum development. Only 2 covered a full cycle of curriculum development. Most were published recently, with first authors mainly from Europe and North America.

Conclusions
Planetary health in medical education is an urgent and hot topic. Literature focused predominantly on why planetary health should be integrated in medical education and what should be covered. The authors recommend future research and education development to shift to how to do so, especially in evaluation and feedback. Research and education development needs to be conducted and reported on systematically and underpinned by educational principles. Lastly, it would benefit from perspectives beyond “Western-based” ones.
Perioperative Infection Prophylaxis With Vancomycin is a Significant Risk Factor for Deep Surgical Site Infection in Spine Surgery
Authors: Kazarian Gregory S. , Mok Jung K. , Johnson Mitchell , Jordan Yusef Y. , Hirase Takashi , Subramanian Tejas , Brause Barry , Kim Han Jo 
Published: July 2024

Study Design.
Retrospective cohort.

Objective.
The purpose of this study was to compare the efficacy of cefazolin versus vancomycin for perioperative infection prophylaxis.

Summary of Background Data.
The relative efficacy of cefazolin alternatives for perioperative infection prophylaxis is poorly understood.

Materials and Methods.
This study was a single-center multisurgeon retrospective review of all patients undergoing primary spine surgery from an institutional registry. Postoperative infection was defined by the combination of three criteria: irrigation and debridement within 3 months of the index procedure, clinical suspicion for infection, and positive intraoperative cultures. Microbiology records for all infections were reviewed to assess the infectious organism and organism susceptibilities. Univariate and multivariate analyses were performed.

Results.
A total of 10,122 patients met inclusion criteria. The overall incidence of infection was 0.78%, with an incidence of 0.73% in patients who received cefazolin and 2.03% in patients who received vancomycin (OR: 2.83, 95% CI: 1.35–5.91, P=0.004). Use of IV vancomycin (OR: 2.83, 95% CI: 1.35–5.91, P=0.006), BMI (MD: 1.56, 95% CI: 0.32–2.79, P=0.014), presence of a fusion (OR: 1.62, 95% CI: 1.04–2.52, P=0.033), and operative time (MD: 42.04, 95% CI: 16.88–67.21, P=0.001) were significant risk factors in the univariate analysis. In the multivariate analysis, only noncefazolin antibiotics (OR: 2.48, 95% CI: 1.18–5.22, P=0.017) and BMI (MD: 1.56, 95% CI: 0.32–2.79, P=0.026) remained significant independent risk factors. Neither IV antibiotic regimen nor topical vancomycin significantly impacted Gram type, organism type, or antibiotic resistance (P>0.05). The most common reason for antibiosis with vancomycin was a penicillin allergy (75.0%).

Conclusions.
Prophylactic antibiosis with IV vancomycin leads to a 2.5 times higher risk of infection compared with IV cefazolin in primary spine surgery. We recommend the routine use of IV cefazolin for infection prophylaxis, and caution against the elective use of alternative regimens like IV vancomycin unless clinically warranted.