bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge of the Human Papillomavirus Vaccine and Willingness to Accept Vaccination in the Postpartum Period
Authors: Chawla Nidhi , Marshall Jennifer , Dubinskaya Alexandra , Wakefield Dorothy , Shepherd Jonathan , Pimentel Veronica Maria 
Published: July 2024

Objectives
Human papillomavirus (HPV) vaccines prevent cervical cancer. The inpatient postpartum period presents a unique window for vaccination. Our study investigates HPV vaccine knowledge, barriers to vaccination, and willingness to get vaccinated during inpatient postpartum care.

Materials and Methods
We conducted a cross-sectional survey of 147 participants, age 18 to 26, who delivered at our institution between November 1, 2019, and April 30, 2020. Participants completed a questionnaire that included demographics, vaccine knowledge, hesitancies, and willingness to vaccinate. We used descriptive statistics and compared groups with chi-square or Wilcoxon rank sum for categorical variables and t-test for continuous variables.

Results
Of the 147 patients, 58 (39.46%) were fully vaccinated against HPV and 89 (60.54%) of participants were unvaccinated or partially vaccinated. There was a greater proportion of African American and Asian participants among unvaccinated women (28.1% vs 20.7% and 16.9% vs 1.7%, respectively). Most unvaccinated participants (52.9%) were willing to get vaccinated in the postpartum unit. Both vaccinated and unvaccinated groups were similarly aware that the HPV vaccine prevents cervical and oropharyngeal cancers and genital warts. The top barrier to future vaccination was forgetting to complete the vaccination series.

Conclusions
Most women were not fully vaccinated but were willing to receive their first dose while in the postpartum unit. African American women were less likely to be vaccinated and expressed more unwillingness to accept vaccination. We identified barriers to HPV vaccination that can be tackled with the initiation of inpatient postpartum vaccination.
A patient with 18p11.32-p11.21 deletion have monaural deafness caused by an inadequate haplodose of THOC1: A case report
Authors: Ouyang Geng , Yi Enhuan , Qin Huali , Duan Xingxing , Wang Sifeng , Peng Xiangwen 
Published: July 2024

Background:
THOC1 mutation causes Deafness, autosomal dominant 86 [OMIM: 620280]. However, it has not been reported whether deletion of the THOC1 gene causes deafness.

Methods:
Here, we report a 1-year-old girl with clinical features including Hypotonia, unilateral deafness in the right ear, and widening of lateral ventricles in 6 months. Gene mutations were identified by whole-exome sequencing.

Results:
Through whole-exome sequencing, a deletion of 18p11.32-p11.21 contains the deletion of all THOC1 genes found in the patient but not in her parents’ genomic DNA. The ClinGen Database Haplodose Insufficiency (HI) prediction tool determined that HI, THOC1 HI may cause unilateral deafness. Moreover, after 6 months of rehabilitation training, muscle tone returned to normal. However, at the age of 1 year, the patient developed symptoms of a large liver and hamartoma of both kidneys.

Conclusion:
From the above results, we propose that in our patient, THOC1 HI may cause unilateral deafness. Therefore, this study provides a new THOC1 deletion associated with unilateral deafness.
Acute therapy-related myelodysplastic syndromes following capecitabine and oxaliplatin therapy in gastric malignant tumor: A case report
Authors: Qian Yi-fan , Chen Hang-ping , Ren Guo-fei 
Published: July 2024

Rational:
Patients with gastric cancer show a relatively low incidence of developing secondary myelodysplastic syndrome (MDS).

Patient concerns:
A 60-year-old man was admitted because of pain and discomfort in the upper abdomen and intermittent abdominal pain.

Diagnoses:
Ulcerative moderately poorly differentiated adenocarcinoma (pT2N2M0G3, stage IIB) and MDS.

Interventions:
The patient underwent chemotherapy with oxaliplatin (OXP, intravenously guttae on day 1) plus capecitabine (CAP, bis in die orally on day 1–14). The patient developed degree III myelosuppression after OXP plus CAP chemotherapy and MDS was subsequently confirmed by diagnosis of the bone marrow biopsy. Temporary but significant hematological improvements were observed after the patient received corresponding treatment, which helped achieve remission and improve pancytopenia.

Outcomes:
The patient presented partial remission after corresponding treatment and no other complications have been recorded.

Lessons:
Acute MDS is an unusual adverse effect induced by OXP plus CAP chemotherapy. It is urgent to suggest implementing a supplementary assessment or examination for patients receiving these therapies in future cases.
Oral health management in children with severe congenital neutropenia with periodontitis: Case report
Authors: Tao Si-Yu , Yao Min , Dong Yu-Lei , Lin Xue-Jing , Sunchuri Diwas , Guo Zhu-Ling 
Published: July 2024

Rationale:
Severe congenital neutropenia (SCN) is a rare and heterogeneous genetic disease. By describing the diagnosis and treatment of a child with SCN and periodontitis, this case provides a reference for the oral health management of a child with SCN and periodontitis.

Patient concerns:
We describe a boy with clinical manifestations of oral bleeding, neutropenia, recurrent fever, and other recurrent infections. The absolute neutrophil count (ANC) was <0.50 × 109/L most of the time. Morphological examination of bone marrow cells showed active granulocyte hyperplasia and dysmaturation.

Diagnoses:
According to the clinical manifestations, hematological examination and gene detection results, the child was diagnosed as SCN with chronic periodontitis.

Interventions:
Periodontal treatment was performed after informed consent was obtained from the child guardian. These included supragingival and subgingival cleaning, hydrogen peroxide and saline irrigation, placement of iodoglycerin in the gingival sulcus, and oral hygiene instruction. Hematopoietic stem cell transplantation (HSCT) was performed later.

Outcomes:
One month after initial periodontal treatment, oral hygiene was well maintained and gingival swelling had subsided. Probing depth (PD) index on periodontal probing and bleeding was significantly reduced. However, there was no significant change in blood routine and other indicators before and after periodontal treatment.

Conclusion:
Once SCN is diagnosed, individualized treatment plans can be developed according to the characteristics of the disease and its impact on oral health, which can effectively control the interaction between SCN and periodontal disease and reduce the occurrence of serious infection.
Desmoid tumors of rectus abdominis: A case report and literature review
Authors: Guo Hong-Peng , Zhang He , Li You , Pan Xing-He , Sun Cheng-Lin , Zhang Jun-Jie 
Published: July 2024

Rationale:
Desmoid tumor (DT) is a rare soft tissue tumor that can occur anywhere in the body. Abdominal wall DT presents unique clinical challenges due to its distinctive manifestations, treatment modalities, and the lack of biomarkers for diagnosis and recurrence prediction, making clinical decisions exceedingly complex.

Patient concerns:
A 32-year-old female who underwent radical resection combined with patch reinforcement for rectus abdominis DT, successfully alleviating abdominal discomfort, with no recurrence during the 6-month follow-up after surgery.

Diagnoses:
Based on the imaging studies and medical history, the patient underwent radical surgical resection. Histopathology reveals that the tumor cells predominantly composed of proliferative fibroblasts with local collagen deposition. The lesional cells show positive staining for β-catenin, indicating a diagnosis of DT.

Interventions:
The patient underwent radical surgical resection with patch reinforcement to repair the abdominal wall defect. Pathology confirmed negative margins, achieving an R0 resection, and genetic testing identified a T41A mutation in CTNNB1. Consequently, no additional adjuvant therapy was administered postoperatively.

Outcomes:
The patient was discharged with the incision healing well after 3 days postoperation. Upon reexamination 6 months later, no recurrence or adverse complications were observed.

Lessons:
Abdominal wall DT treatment requires personalized plans from multidisciplinary team discussions. Genetic testing plays a crucial role in identifying novel biomarkers for abdominal wall DT. We have once again demonstrated the significant clinical significance of CTNNB1 mutations in the diagnosis and progression of abdominal wall DT. Additionally, genes such as CCND1, CYP3A4, SLIT1, RRM1, STIM1, ESR2, UGT1A1, among others, may also be closely associated with the progression of abdominal wall DT. Future research should delve deeper into and systematically evaluate the precise impact of these genetic mutations on treatment selection and prognosis for abdominal wall DT, in order to better guide patient management and treatment decisions.
Acute chest syndrome in sickle cell disease
Authors: Talarico Annamarie M. 
Published: July 2024

Abstract:
Sickle cell disease (SCD) is an autosomal recessive disorder altering the shape of red blood cells, causing harmful obstructions in blood vessels, therefore altering normal blood flow. SCD can escalate quickly into acute chest syndrome (ACS), a life-threatening complication that requires immediate care. This article discusses the pathophysiology, assessment, diagnosis, and treatment of ACS, as well as nursing care and patient education.
The “Double Victim Phenomenon”: Results From a National Pilot Survey on Second Victims in German Family Caregivers (SeViD-VI Study)
Authors: Bushuven Stefan , Trifunovic-Koenig Milena , Klemm Victoria , Diesener Paul , Haller Susanne , Strametz Reinhard 
Published: July 2024

Introduction
Second-victim phenomena may lead to severe reactions like depression or posttraumatic disorder, as well as dysfunction and absenteeism. Medical error as a cause for second victims is not limited to professionals, as family caregivers care for millions of patients at home. It remains unclear whether these are first, second, or double victims in case of error. This explorative study investigated whether second victim effects and signs of moral injury are detectable in family caregivers and whether existing instruments are applicable in lay persons.

Methods
In an open convenience sampling online survey, we recruited 66 German family caregivers. Propensity score matching was conducted to obtain a balanced sample of family caregivers and qualified nurses who took part in the previous study by adjusting for age and sex. The groups were compared regarding the German Version of the Second Victim Experience and Support Tool-Revised and the German version of the Moral Injury Symptom and Support Scale for Health Professionals.

Results
Sixty-six caregivers participated, of whom 31 completed the survey. Of all, 58% experienced a second victim-like effect, 35% experienced a prolonged effect, and 45% reported to still suffer from it. In a matched sample (22 family caregivers and 22 nurses), no significant differences were observed between the groups.

Discussion
Regarding the limitations of this pilot study, demanding for resampling in larger populations, we could show that second victim effects and moral injury are detectable in family caregivers by validated instruments and are not inferior to professionals’ experiences. Concerning the demand for further studies, we confirmed the applicability of the testing instruments but with need for item reduction to lower response burden.
Threatening an Illusory Limb: An Event-related Potential Study of the Rubber Hand Illusion
Authors: Heldmann Marcus , Spitta Gregor , Wagner-Altendorf Tobias , Münte Thomas F. 
Published: July 2024

Background:
The rubber hand illusion (RHI) is a well-established method for studying body ownership: Given adequate concordance of visual, sensory, and proprioceptive stimuli, the individual experiences a rubber hand as his or her own.

Objective:
To study the effects of a threat to the rubber hand.

Methods:
We created a typical RHI paradigm but added threatening pain: Both the real hand of an individual and the rubber hand were stroked with a brush, either synchronously (RHI-inducing condition) or asynchronously (control condition), but only the rubber hand was then pricked with a needle to create a threatening pain condition. Event-related potentials (ERPs) were recorded in a group of 23 typically-developed individuals. ERP effects were source-localized using low-resolution electromagnetic tomography.

Results:
The individuals consistently reported experience of the RHI during the experiment when the brush strokes were applied synchronously to both the real hand and the rubber hand. ERP analysis revealed that synchronous brush stroking gave rise to higher amplitude of frontal ERPs in the 100–200 ms range than asynchronous brush stroking, which was interpreted as reflecting the RHI. In the threatening pain condition, ERPs showed a greater positivity at frontocentral electrodes, source localized in the supplementary motor area (SMA).

Conclusion:
SMA activation could reflect a control mechanism over reflexive motor activity, facilitating a possible threat-related response. Further studies should address ERP effects and the extent of the RHI to standard and threat stimuli in a correlative fashion to further elucidate the functional significance of the neurophysiological findings.
Cross-modal interaction of Alpha Activity does not reflect inhibition of early sensory processing: A frequency tagging study using EEG and MEG
Authors: Brickwedde M. , Limachya R. , Markiewicz R. , Sutton E. , Postzich C. , Shapiro K. , Jensen O. , Mazaheri A. 
Published: July 2024

AbstractSelective attention involves prioritizing relevant sensory input while suppressing irrelevant stimuli. It has been proposed that oscillatory alpha-band activity (∼10 Hz) aids this process by functionally inhibiting early sensory regions. However, recent studies have challenged this notion. Our EEG and MEG studies aimed to investigate whether alpha oscillations serve as a ‘gatekeeper’ for downstream signal transmission. We first observed these effects in an EEG study and then replicated them using MEG, which allowed us to localize the sources.We employed a cross-modal paradigm where visual cues indicated whether upcoming targets required visual or auditory discrimination. To assess inhibition, we utilized frequency-tagging, simultaneously flickering the fixation cross at 36 Hz and playing amplitude-modulated white noise at 40 Hz during the cue-to-target interval.Consistent with prior research, we observed an increase in posterior alpha activity following cues signalling auditory targets. However, remarkably, both visual and auditory frequency tagged responses amplified in anticipation of auditory targets, correlating with alpha activity amplitude. Our findings suggest that when attention shifts to auditory processing, the visual stream remains responsive and is not hindered by occipital alpha activity. This implies that alpha modulation does not solely regulate ‘gain control’ in early sensory areas but rather orchestrates signal transmission to later stages of the processing stream.
Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins
Authors: Gillespie Nathan A. , Neale Michael C. , Panizzon Matthew S. , McKenzie Ruth E. , Tu Xin M. , Xian Hong , Reynolds Chandra A. , Lyons Michael J. , Rissman Robert A. , Elman Jeremy A. , Franz Carol , Kremen William S. 
Published: July 2024

AbstractINTRODUCTIONThe amyloid cascade hypothesis predicts that amyloid-beta (Aβ) aggregation drives tau tangle accumulation. We tested competing causal and non-causal hypotheses regarding the direction of causation between Aβ40 and Aβ42 and total Tau (t-Tau) plasma biomarkers.METHODSPlasma Aβ40, Aβ42, t-Tau, and neurofilament light chain (NFL) were measured in 1,035 men (mean = 67.0 years) using Simoa immunoassays. Genetically informative twin modeling tested the direction of causation between Aβs and t-Tau.RESULTSNo clear evidence that Aβ40 or Aβ42 directly causes changes in t-Tau was observed; the alternative causal hypotheses also fit the data well. In contrast, exploratory analyses suggested a causal impact of the Aβ biomarkers on NFL. Separately, reciprocal causation was observed between t-Tau and NFL.DISCUSSIONPlasma Aβ40 or Aβ42 do not appear to have a direct causal impact on t-Tau. In contrast, Aβ aggregation may causally impact NFL in cognitively unimpaired men in their late 60s.
Treatment Outcome in Patients With Spinal Neurocysticercosis: A Systematic Review of Published Cases and Case Series
Authors: Garg Ravindra Kumar , Rizvi Imran , Nigam Harish , Pandey Shweta , Uniyal Ravi 
Published: July 2024

AbstractBackgroundSpinal neurocysticercosis is a rare central nervous system infection caused by the larval form of theTaenia soliumtapeworm. Due to its rarity, most knowledge is derived from isolated case reports.ObjectivesThis systematic review aims to evaluate existing case reports and observational studies to provide a comprehensive overview of the disease’s clinical presentation, and treatment outcomes.MethodsAdhering to PRISMA guidelines, a search was conducted across multiple databases including PubMed, Scopus, Embase, and Google Scholar. Case reports, case series, and observational studies were included. The review is registered with PROSPERO (CRD42024496957).ResultsThe search yielded 163 records describing 197 patients. Symptoms ranged from one week to over three years, with the most common being paraparesis or quadriparesis (61%) and back pain. Treatment modalities varied. with a combination of surgery and cysticidal drugs being the most preferred (45.2%) treatment. Surgery was done in 77% (152/197) of cases. In 45 % of cases (89/197) cysticidal drugs were given following surgery. Medical treatment alone was given to 22% (43/197) of patients.The majority of cases (92%) irrespective of treatment modality showed clinical improvement. Post-operative complications caused three deaths.ConclusionsWe noted that surgery followed by cysticidal drugs was the most preferred treatment. Medical treatment alone was given to many patients. Clinical improvement was observed in most cases, regardless of the treatment option used. The use of cysticidal drugs could eliminate the need for surgery in many spinal neurocysticercosis patients.Key messageMost spinal neurocysticercosis patients improve clinically with surgery and cysticidal drugs, the most common treatment. Medical management alone also benefits many, suggesting potential to reduce surgical intervention with effective drug therapy.
Analyzing the Factor Structure and Sleep Quality of Pittsburgh Sleep Quality Index in Indian Information Technology Sector
Authors: Chatterjee Arindam , Dutta Arijit , Chaudhuri Rimu 
Published: July 2024

AbstractThe Pittsburgh Sleep Quality Index (PSQI) has gained widespread acceptance as a useful tool to measure sleep quality. In order to formulate the diagnosis process, it is essential that we understand the factor structure inherent in the PSQI data. In this work, we seek to estimate such a structure with a focus on the Indian Information Technology (IT) workers. We have used Confirmatory Factor Analysis (CFA) and the Exploratory Factor Analysis (EFA) for this purpose. Instead of using random imputation to handle the frequently occurring missing values, we have used more sophisticated techniques thereby improving the accuracy of our results. We have also used the Multi layer perceptron based method to see how we can classify the sleep quality of the sampled population. We have discovered that, contrary to the general perception, most Indian IT employees have sleep quality belonging to good and very good classes.Author summaryArindam Chatterjee - Curently Assistant Professor of Computer Science and Engineering, Heritage Institute of Technology, Kolkata. Arindam has almost 16 years of teaching and research experience. In past he has worked in the industry for eight years. Area of academic interest is Impact of Information Technology on Indian Financial and Social sectors.Rimu Chaudhuri -Currently Professor of Economics, Heritage Business School, Kolkata. Rimu is having teaching experience of almost 16yrs and research experience of 20 yrs. Area of academic / research interest is Entrepreneurship Development and for last couple of years Rimu is working in the field of Gender and Environment Sustainability. Last couple of years Rimu has worked extensively on Social Impact of IT. Rimu is also the President of Institution’s Innovation Council of Heritage Business School.Arijit is a software engineer at Bloomberg LP, with a Master’s degree in Computer Science from the University of Florida. He specializes in creating and maintaining low-latency, high-performant, and robust backend applications. Arijit has a keen interest in Distributed Systems and Software Development. Currently, he contributes his expertise to the ESG (Environmental, Social, and Governance) sector, managing proprietary datasets and developing services that handle millions of requests per day. His work ensures efficient and reliable data management in a high-demand environment.
Symptom Cluster Profiles among Community-residing Older Adults with Heart Failure: Findings from the U.S. Health and Retirement Study
Authors: Wang Zequan , JEON Sangchoon , TOCCHI Christine , CONLEY Samantha , WALSH Stephen , KIM Kyounghae , CHYUN Deborah , REDEKER Nancy Schmieder 
Published: July 2024

ABSTRACTBackgroundThe incidence of heart failure (HF) rises significantly as people age due to the accumulated influence of risk factors in cardiovascular structure and function. Among older adults with HF, symptoms are manifested in clustered symptoms. Few studies have addressed symptoms specifically in older adults with HF and most have been conducted with small samples. The aims of this study were to (1) describe symptom cluster profiles in older adults with HF in a nationally representative sample of community-dwelling older adults; and (2) determine the associations between demographic and clinical characteristics and membership in symptom cluster profiles.MethodsA secondary analysis was conducted using data from the Health and Retirement Study. Fatigue, shortness of breath, pain, swelling, depressive symptoms, and dizziness were measured. Latent class analysis was used to identify symptom cluster profiles. Bivariate associations and multinomial logistic regression were used to determine the associations between symptom cluster profiles and demographic and clinical characteristics.ResultsThe sample included 690 participants. Three symptom cluster profiles were identified [high-burden, low-burden, and cardiopulmonary-depressive]. Age, gender, BMI, marital status, alcohol consumption, diabetes, lung disease, and arthritis were significantly different across the three profiles. People in the high-burden and cardiopulmonary-depressive profiles, compared to those in low-burden, had higher odds of having lung disease and arthritis, yet lower odds of higher alcohol consumption.ConclusionsOlder adults with HF residing in the community experienced distinct symptom cluster profiles. Research is needed to identify and test targeted interventions for specific symptom cluster profiles.