bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of economic austerity and prosperity events on suicide in Greece: a 30-year interrupted time-series analysis
Authors: Branas Charles C , Kastanaki Anastasia E , Michalodimitrakis Manolis , Tzougas John , Kranioti Elena F , Theodorakis Pavlos N , Carr Brendan G , Wiebe Douglas J 
Published: February 2015

ObjectivesTo complete a 30-year interrupted time-series analysis of the impact of austerity-related and prosperity-related events on the occurrence of suicide across Greece.SettingGreece from 1 January 1983 to 31 December 2012.ParticipantsA total of 11 505 suicides, 9079 by men and 2426 by women, occurring in Greece over the study period.Primary and secondary outcomesNational data from the Hellenic Statistical Authority assembled as 360 monthly counts of: all suicides, male suicides, female suicides and all suicides plus potentially misclassified suicides.ResultsIn 30 years, the highest months of suicide in Greece occurred in 2012. The passage of new austerity measures in June 2011 marked the beginning of significant, abrupt and sustained increases in total suicides (+35.7%, p<0.001) and male suicides (+18.5%, p<0.01). Sensitivity analyses that figured in undercounting of suicides also found a significant, abrupt and sustained increase in June 2011 (+20.5%, p<0.001). Suicides by men in Greece also underwent a significant, abrupt and sustained increase in October 2008 when the Greek recession began (+13.1%, p<0.01), and an abrupt but temporary increase in April 2012 following a public suicide committed in response to austerity conditions (+29.7%, p<0.05). Suicides by women in Greece also underwent an abrupt and sustained increase in May 2011 following austerity-related events (+35.8%, p<0.05). One prosperity-related event, the January 2002 launch of the Euro in Greece, marked an abrupt but temporary decrease in male suicides (−27.1%, p<0.05).ConclusionsThis is the first multidecade, national analysis of suicide in Greece using monthly data. Select austerity-related events in Greece corresponded to statistically significant increases for suicides overall, as well as for suicides among men and women. The consideration of future austerity measures should give greater weight to the unintended mental health consequences that may follow and the public messaging of these policies and related events.
A survey of major trauma centre staffing in England
Authors: Jansen Jan O , Morrison J J , Tai N R M , Midwinter M J 
Published: February 2015

IntroductionTrauma care delivery in England has been transformed by the development of trauma networks, and the designation of trauma centres. A specialist trauma service is a key component of such centres. The aim of this survey was to determine to which extent, and how, the new major trauma centres (MTCs) have been able to implement such services.MethodsElectronic questionnaire survey of MTCs in England.ResultsAll 22 MTCs submitted responses. Thirteen centres have a dedicated major trauma service or trauma surgery service, and a further four are currently developing such a service. In 7 of these 17 centres, the service is or will be provided by orthopaedic surgeons, in 2 by emergency medicine departments, in another 2 by general or vascular surgeons, and in 6 by a multidisciplinary group of consultants.DiscussionA large proportion of MTCs still do not have a dedicated major trauma service. Furthermore, the models which are emerging differ from other countries. The relative lack of involvement of surgeons in MTC trauma service provision is particularly noteworthy, and a potential concern. The impact of these different models of service delivery is not known, and warrants further study.
First-order topography of the Himalayan Mountain belt: a deep-crustal flow analysis
Authors: Mandal Nibir , Bose Santanu , Baruah Amiya , Sarkar Shamik 
Published: February 2015

Abstract

This study investigates the first-order Himalayan mountain topography from the perspective of deep-crustal flow patterns in the Indo-Asia collision zone. Using a thin-viscous-sheet model we theoretically predict that flat hinterland topography with a stable elevation (Type I) can develop only when the lithospheric slab underthrusts with a threshold velocity (
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s
*). For
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s
>
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s
*, the hinterland continuously gains in elevation, leading to Type II topography. This type is characterized by varying first-order surface slopes, but always facing the mountain front. Conversely, the elevated hinterland masses undergo gravity-driven subsidence, forming a topography (Type III) with characteristic backward surface slopes when
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s
<
V
s
*. We evaluate
V
s
* as a function of: (i) the regional slope of the initial first-order surface topography (α); (ii) the angle of underthrusting (β); and (iii) the relative width of foreland plain (λ), assuming little effects of surface erosion. Our model shows two characteristic deep-crustal flow patterns: corner flow and vortex flow. The corner flow pattern, described by upwardly pointed hyperbolic streamlines, is responsible for Type II topography. Conversely, the vortex flow leads to Type III, whereas the transition between the two gives rise to Type I. This corner-to-vortex type flow transition commences on decreasing
V
s
.
Representation of Group Isomorphisms: The Compact Case
Authors: Ferrer Marita , Gary Margarita , Hernández Salvador 
Published: February 2015

LetGbe a discrete group and letAandBbe two subgroups ofG-valued continuous functions defined on two 0-dimensional compact spacesXandY. A group isomorphismHdefined betweenAandBis calledseparatingwhen, for each pair of mapsf, g∈Asatisfying thatf-1eG∪g-1eG=X, it holds thatHf-1eG∪Hg-1eG=Y. We prove that under some mild conditions every biseparating isomorphismH:A→Bcan be represented by means of a continuous functionh:Y→Xas a weighted composition operator. As a consequence we establish the equivalence of two subgroups of continuous functions if there is a biseparating isomorphism defined between them.
Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth
Authors: Gritsina Galina , Xiao Fang , O'Brien Shane W. , Gabbasov Rashid , Maglaty Marisa A. , Xu Ren-Huan , Thapa Roshan J. , Zhou Yan , Nicolas Emmanuelle , Litwin Samuel , Balachandran Siddharth , Sigal Luis J. , Huszar Dennis , Connolly Denise C. 
Published: February 2015

Abstract
Ovarian carcinoma is the fifth leading cause of death among women in the United States. Persistent activation of STAT3 is frequently detected in ovarian carcinoma. STAT3 is activated by Janus family kinases (JAK) via cytokine receptors, growth factor receptor, and non–growth factor receptor tyrosine kinases. Activation of STAT3 mediates tumor cell proliferation, survival, motility, invasion, and angiogenesis, and recent work demonstrates that STAT3 activation suppresses antitumor immune responses and supports tumor-promoting inflammation. We hypothesized that therapeutic targeting of the JAK/STAT3 pathway would inhibit tumor growth by direct effects on ovarian carcinoma cells and by inhibition of cells in the tumor microenvironment (TME). To test this, we evaluated the effects of a small-molecule JAK inhibitor, AZD1480, on cell viability, apoptosis, proliferation, migration, and adhesion of ovarian carcinoma cells in vitro. We then evaluated the effects of AZD1480 on in vivo tumor growth and progression, gene expression, tumor-associated matrix metalloproteinase (MMP) activity, and immune cell populations in a transgenic mouse model of ovarian carcinoma. AZD1480 treatment inhibited STAT3 phosphorylation and DNA binding, and migration and adhesion of cultured ovarian carcinoma cells and ovarian tumor growth rate, volume, and ascites production in mice. In addition, drug treatment led to altered gene expression, decreased tumor-associated MMP activity, and fewer suppressor T cells in the peritoneal TME of tumor-bearing mice than control mice. Taken together, our results show pharmacologic inhibition of the JAK2/STAT3 pathway leads to disruption of functions essential for ovarian tumor growth and progression and represents a promising therapeutic strategy. Mol Cancer Ther; 14(4); 1035–47. ©2015 AACR.
Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments
Authors: Loganzo Frank , Tan Xingzhi , Sung Matthew , Jin Guixian , Myers Jeremy S. , Melamud Eugene , Wang Fang , Diesl Veronica , Follettie Maximillian T. , Musto Sylvia , Lam My-Hanh , Hu William , Charati Manoj B. , Khandke Kiran , Kim Kenny Sung Kyoo , Cinque Mike , Lucas Judy , Graziani Edmund , Maderna Andreas , O'Donnell Christopher J. , Arndt Kim T. , Gerber Hans-Peter 
Published: February 2015

AbstractAntibody–drug conjugates (ADC) are emerging as clinically effective therapy. We hypothesized that cancers treated with ADCs would acquire resistance mechanisms unique to immunoconjugate therapy and that changing ADC components may overcome resistance. Breast cancer cell lines were exposed to multiple cycles of anti-Her2 trastuzumab–maytansinoid ADC (TM-ADC) at IC80 concentrations followed by recovery. The resistant cells, 361-TM and JIMT1-TM, were characterized by cytotoxicity, proteomic, transcriptional, and other profiling. Approximately 250-fold resistance to TM-ADC developed in 361-TM cells, and cross-resistance was observed to other non–cleavable-linked ADCs. Strikingly, these 361-TM cells retained sensitivity to ADCs containing cleavable mcValCitPABC-linked auristatins. In JIMT1-TM cells, 16-fold resistance to TM-ADC developed, with cross-resistance to other trastuzumab-ADCs. Both 361-TM and JIMT1-TM cells showed minimal resistance to unconjugated mertansine (DM1) and other chemotherapeutics. Proteomics and immunoblots detected increased ABCC1 (MRP1) drug efflux protein in 361-TM cells, and decreased Her2 (ErbB2) in JIMT1-TM cells. Proteomics also showed alterations in various pathways upon chronic exposure to the drug in both cell models. Tumors derived from 361-TM cells grew in mice and were refractory to TM-ADC compared with parental cells. Hence, acquired resistance to trastuzumab–maytansinoid ADC was generated in cultured cancer cells by chronic drug treatment, and either increased ABCC1 protein or reduced Her2 antigen were primary mediators of resistance. These ADC-resistant cell models retain sensitivity to other ADCs or standard-of-care chemotherapeutics, suggesting that alternate therapies may overcome acquired ADC resistance. Mol Cancer Ther; 14(4); 952–63. ©2015 AACR.
Smoking Is Associated with Acute and Chronic Prostatic Inflammation: Results from the REDUCE Study
Authors: Moreira Daniel M. , Nickel J. Curtis , Gerber Leah , Muller Roberto L. , Andriole Gerald L. , Castro-Santamaria Ramiro , Freedland Stephen J. 
Published: February 2015

AbstractBoth anti- and proinflammatory effects of cigarette smoking have been described. As prostate inflammation is common, we hypothesized smoking could contribute to prostate inflammation. Thus, we evaluated the association of smoking status with acute and chronic inflammation within the prostate of men undergoing prostate biopsy. We retrospectively analyzed 8,190 men ages 50 to 75 years with PSA levels between 2.5 and 10 ng/mL enrolled in the Reduction by Dutasteride of Prostate Cancer Events study. Smoking status was self-defined as never, former, or current. Prostate inflammation was assessed by systematic central review blinded to smoking status. The association of smoking with inflammation in the baseline, 2-year, and 4-year biopsies was evaluated with univariable and multivariable logistic regressions. At study enrollment, 1,233 (15%), 3,203 (39%), and 3,754 (46%) men were current, former, and never smokers, respectively. Current smokers were significantly younger and had smaller prostates than former and never smokers (all P &lt; 0.05). Former smokers were significantly heavier than current and never smokers (P &lt; 0.001). Acute and chronic prostate inflammations were identified in 1,261 (15%) and 6,352 (78%) baseline biopsies, respectively. In univariable analysis, current smokers were more likely to have acute inflammation than former (OR, 1.35; P, 0.001) and never smokers (OR, 1.36; P, 0.001). The results were unchanged at 2- and 4-year biopsies. In contrast, current smoking was linked with chronic inflammation in the baseline biopsy, but not at 2- and 4-year biopsies. In conclusion, among men undergoing prostate biopsy, current smoking was independently associated with acute and possibly chronic prostate inflammations. Cancer Prev Res; 8(4); 312–7. ©2015 AACR.
Impedidos de "tratar da vida": os desafios enfrentados pelos libertos na sociedade colonial
Authors: Pinheiro Fernanda Domingos 
Published: February 2015

<p>As possibilidades de acesso à alforria e sua frequência proporcionaram a formação de um importante contingente de libertos na América portuguesa. Porém, a essa camada da sociedade colonial foram impostos muitos e diferentes desafios. Perceber os riscos e as limitações que embaraçaram ou impediram o gozo de uma liberdade plena é o propósito deste artigo. </p>
“O livro que quase não foi escrito”: revisitando o Milagre em Joaseiro
Authors: Lima Raquel dos Santos Sousa 
Published: February 2015

<p>Resenha do livro</p><p> </p><p>DELLA CAVA, Ralph. <em>Milagre em Joaseiro</em>. Tradução de Maria Yedda Linhares. 3ª edição. São Paulo: Companhia das Letras, 2014.</p>
Toward Quantifying the Increasing Role of Oceanic Heat in Sea Ice Loss in the New Arctic
Authors: Carmack E. , Polyakov I. , Padman L. , Fer I. , Hunke E. , Hutchings J. , Jackson J. , Kelley D. , Kwok R. , Layton C. , Melling H. , Perovich D. , Persson O. , Ruddick B. , Timmermans M.-L. , Toole J. , Ross T. , Vavrus S. , Winsor P. 
Published: February 2015

Abstract
The loss of Arctic sea ice has emerged as a leading signal of global warming. This, together with acknowledged impacts on other components of the Earth system, has led to the term “the new Arctic.” Global coupled climate models predict that ice loss will continue through the twenty-first century, with implications for governance, economics, security, and global weather. A wide range in model projections reflects the complex, highly coupled interactions between the polar atmosphere, ocean, and cryosphere, including teleconnections to lower latitudes. This paper summarizes our present understanding of how heat reaches the ice base from the original sources—inflows of Atlantic and Pacific Water, river discharge, and summer sensible heat and shortwave radiative fluxes at the ocean/ice surface—and speculates on how such processes may change in the new Arctic. The complexity of the coupled Arctic system, and the logistic and technological challenges of working in the Arctic Ocean, require a coordinated interdisciplinary and international program that will not only improve understanding of this critical component of global climate but will also provide opportunities to develop human resources with the skills required to tackle related problems in complex climate systems. We propose a research strategy with components that include 1) improved mapping of the upper- and middepth Arctic Ocean, 2) enhanced quantification of important process, 3) expanded long-term monitoring at key heat-flux locations, and 4) development of numerical capabilities that focus on parameterization of heat-flux mechanisms and their interactions.
The DACCIWA Project: Dynamics–Aerosol–Chemistry–Cloud Interactions in West Africa
Authors: Knippertz Peter , Coe Hugh , Chiu J. Christine , Evans Mat J. , Fink Andreas H. , Kalthoff Norbert , Liousse Catherine , Mari Celine , Allan Richard P. , Brooks Barbara , Danour Sylvester , Flamant Cyrille , Jegede Oluwagbemiga O. , Lohou Fabienne , Marsham John H. 
Published: February 2015

Abstract
Massive economic and population growth, and urbanization are expected to lead to a tripling of anthropogenic emissions in southern West Africa (SWA) between 2000 and 2030. However, the impacts of this on human health, ecosystems, food security, and the regional climate are largely unknown. An integrated assessment is challenging due to (a) a superposition of regional effects with global climate change; (b) a strong dependence on the variable West African monsoon; (c) incomplete scientific understanding of interactions between emissions, clouds, radiation, precipitation, and regional circulations; and (d) a lack of observations. This article provides an overview of the DACCIWA (Dynamics–Aerosol–Chemistry–Cloud Interactions in West Africa) project. DACCIWA will conduct extensive fieldwork in SWA to collect high-quality observations, spanning the entire process chain from surface-based natural and anthropogenic emissions to impacts on health, ecosystems, and climate. Combining the resulting benchmark dataset with a wide range of modeling activities will allow (a) assessment of relevant physical, chemical, and biological processes; (b) improvement of the monitoring of climate and atmospheric composition from space; and (c) development of the next generation of weather and climate models capable of representing coupled cloud–aerosol interactions. The latter will ultimately contribute to reduce uncertainties in climate predictions. DACCIWA collaborates closely with operational centers, international programs, policymakers, and users to actively guide sustainable future planning for West Africa. It is hoped that some of DACCIWA’s scientific findings and technical developments will be applicable to other monsoon regions.
Laser Ceilometer Investigation of Persistent Wintertime Cold-Air Pools in Utah’s Salt Lake Valley
Authors: Young Joseph Swyler , Whiteman C. David 
Published: February 2015

AbstractAs part of the winter 2010/11 Persistent Cold-Air Pool Study in Utah’s Salt Lake Valley, a laser ceilometer was used to continuously measure aerosol-layer characteristics in support of an investigation of the meteorological processes producing the cold-air pools. A surface-based aerosol layer was present during much of the winter. Comparisons were made between ceilometer-measured and visual characteristics of the aerosol layers. A 3–4 January 2011 case study illustrated the meteorological value of time–height backscatter cross sections when used as a base map for meteorological analyses. A variety of meteorological mixing processes were illustrated using ceilometer backscatter data. The mean altitude of the top of the aerosol layer during undisturbed subperiods of the 1 December–7 February experimental period was 1811 m MSL, with a standard deviation of 185 m. The mean aerosol depth was ~500 m AGL in the 1200-m-deep valley. There was surprisingly little variation in the wintertime aerosol layer depth despite large variations in bulk atmospheric stability and ground-based fine particulate matter concentrations.
Patterns of Diurnal Marine Stratocumulus Cloud Fraction Variability
Authors: Burleyson Casey D. , Yuter Sandra E. 
Published: February 2015

AbstractThe spatial patterns of subtropical marine stratocumulus cloud fraction variability on diurnal time scales are examined using high-temporal-resolution cloud masks that are based on 30-min, 4 km × 4 km geosynchronous infrared data for 2003–10. This dataset permits comparison of the characteristics of variability in low cloud fraction among the three subtropical marine stratocumulus regions in the northeastern (NE) Pacific, southeastern (SE) Pacific, and SE Atlantic Oceans. In all three regions, the largest diurnal cycles and earliest time of cloud breakup occur on the edges of the cloud field where cloud fractions are generally lower. The rate at which the cloud breaks up during the day is tied to the starting cloud fraction at dawn, which determines the amount of longwave cooling that is initially available to offset shortwave radiative fluxes during the day. The maximum rate of cloud breakup occurs near 1200 LT. Cloud fraction begins to increase by 1600 LT (before the sun sets) and reaches its maximum value just before dawn. The diurnal-cycle characteristics of the SE Pacific and SE Atlantic marine stratocumulus cloud decks are more similar to each other than to those in the NE Pacific. The NE Pacific cloud deck has a smaller-amplitude diurnal cycle, slower rates of cloud breakup during the day for a given cloud fraction at dawn, and a higher probability of cloud breakup overnight.
Drought over East Asia: A Review
Authors: Zhang Lixia , Zhou Tianjun 
Published: February 2015

AbstractEast Asia is greatly impacted by drought. North and southwest China are the regions with the highest drought frequency and maximum duration. At the interannual time scale, drought in the eastern part of East Asia is mainly dominated by two teleconnection patterns (i.e., the Pacific–Japan and Silk Road teleconnections). The former is forced by SST anomalies in the western North Pacific and the tropical Indian Ocean during El Niño decaying year summers. The precipitation anomaly features a meridional tripolar or sandwich pattern. The latter is forced by Indian monsoon heating and is a propagation of stationary Rossby waves along the Asian jet in the upper troposphere. It can significantly influence the precipitation over north China. Regarding the long-term trend, there exists an increasing drought trend over central parts of northern China and a decreasing tendency over northwestern China from the 1950s to the present. The increased drought in north China results from a weakened tendency of summer monsoons, which is mainly driven by the phase transition of the Pacific decadal oscillation. East Asian summer precipitation is poorly simulated and predicted by current state-of-the-art climate models. Encouragingly, the predictability of atmospheric circulation is high because of the forcing of ENSO and the associated teleconnection patterns. Under the SRES A1B scenario and doubled CO2 simulations, most climate models project an increasing drought frequency and intensity over southeastern Asia. Nevertheless, uncertainties exist in the projections as a result of the selection of climate models and the choice of drought index.
Generation of a Quasi-Biennial Oscillation in an NWP Model Using a Stochastic Gravity Wave Drag Parameterization
Authors: McCormack John P. , Eckermann Stephen D. , Hogan Timothy F. 
Published: February 2015

Abstract
Many operational numerical weather prediction (NWP) systems now extend into the stratosphere and are beginning to be used to generate forecasts beyond conventional 5–10-day periods out to seasonal time scales. Past observational and modeling studies have shown that the quasi-biennial oscillation (QBO) in equatorial stratospheric winds can play an important role in stratosphere–troposphere dynamical coupling over these longer time scales. Consequently, stratosphere-resolving NWP models used to generate seasonal forecasts should contain the necessary physics to generate and maintain the QBO. This study describes several key modifications that were necessary to produce a QBO in a high-altitude NWP model, which include an increase in model vertical resolution, implementation of a computationally efficient stochastic gravity wave drag parameterization, and reductions in the amount of horizontal and vertical diffusion in the stratosphere. Results from a 10-yr free-running model simulation with these modifications show that the westerly QBO phase produces lower temperatures and stronger westerly flow in the Northern Hemisphere (NH) winter polar stratosphere compared to the easterly QBO phase. Ensembles of 120-day simulations over the December–March period show that these modifications replace persistent easterly flow in the equatorial lower stratosphere with a more realistic transition from easterly to westerly flow. The resulting changes in planetary wave propagation produce a statistically significant response in the dynamics of the NH extratropical stratosphere consistent with the Holton–Tan relationship. The westerly shift in equatorial winds also produces a significant response in the NH extratropical troposphere, where the sea level pressure differences in winter resemble the positive phase of the northern annular mode.