bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of Artificial Lighting Using Dialux Evo to Evaluate Lighting Conditions and Electricity Consumption in Handicraft Rooms
Authors: Saffar May Al 
Published: July 2024

Abstract

This research paper investigates the role and contribution of artificial lighting on handicraft centers in the process of crafts making with limited daylight. These centres were designed to shed light on local handicraft manufacturing and display. The objective was to evaluate the artificial lighting performance, and its impacts on the craftsperson's visual comfort concerning the recommended lighting levels in the given setting, as well as the overall electricity consumption. Hence, a mixed method of case-study analysis was used to evaluate the daylight factor, and the existing artificial lighting layout and illumination level, site documentation through photographs and informal conversations was used to explore the craftsperson’s perception and visual experience, and computer simulation using Dialux evo lighting design software was applied to evaluate the existing lighting levels and propose new lighting solutions for better illumination distribution and electricity conservation. Three handicraft units in Al Jasra Handicraft Centre, Bahrain were selected: gypsum engraving, textile weaving, and pottery-making crafts units. The units were selected based on the level of difficulty and recommended illumination levels. The findings suggest that illumination in the existing handicraft units exceeds the recommended levels, which negatively affects the artisans’ visual comfort and consequently impacts the quality of the produced products. Moreover, excessive lighting may increase the warmness of the indoor environment and increase electricity consumption. The difficulty in creating an optimum lighting design may reside in a combination of factors: the type of handicraft and its level of detail, the type of luminaires and its mounted height from the work plane, as each craft has a specific setting and requirements. Finally, a new lighting layout and new lighting fixtures are suggested, considering the lighting layers to create the best atmosphere to meet the functional and aesthetical demands required in a handicraft unit. In addition, this study’s ambition is to provide some lighting design directions for architects, handicraft centres, and artisans in Bahrain and beyond.
Elderly patient with squamous cell carcinoma of the lung with irAE-associated hidden myocarditis: A case report
Authors: Kodaka Norio , Hayashi Noriyuki , Asakawa Nanae , Yoshida Masahiro , Watanabe Kayo , Matsuse Hiroto 
Published: July 2024

Abstract

Background: Immune checkpoint inhibitors (ICIs) are the standard therapy for various types of cancer. One of them, durvalumab, as a programmed cell death ligand 1 (PD-L1) inhibitor, is commonly used to treat pulmonary malignancies. It has a wide range of known side effects, known as immune-related adverse events (irAEs). Myocarditis as an irAEs is rare but fatal. Currently, there is a paucity of reports on myocarditis as an irAE after durvalumab treatment in elderly patients.
Case presentation: The patient was a 79-year-old female with stage Ⅲb squamous cell lung carcinoma and myocarditis as an irAE after durvalumab treatment.
She had completed two cycles of carboplatin and TS-1 and received 50 Gy of radiation. After combined chemotherapy and radiotherapy (CCRT), she was administered 10 mg/kg of durvalumab every two weeks as maintenance therapy. After eleven courses over five months of durvalumab, despite the absence of complaints, she experienced a significant decline in cardiac function as observed via echocardiography. Blood tests revealed elevated levels of high-sensitivity cardiac troponin T(hs-cTn). The diagnosis of myocarditis was confirmed through a myocardial biopsy, indicating that it was an irAE following durvalumab therapy. Her myocarditis improved with the discontinuation of durvalumab treatment and the administration of steroid therapy.
She has been successfully treated for lung cancer for more than two years without flare-up of myocarditis or lung cancer deterioration, although no treatment for lung cancer has been attempted since the occurrence of myocarditis.
Conclusion:In patients on ICIs, especially elderly patients, it is important to pay attention to irAEs and perform periodic electrocardiograms and ECGs, even in asymptomatic persons, for early detection and prognosis improvement.
Phase II trial evaluating the long-term efficacy and peripheral sensory neuropathy of adjuvant XELOX in Japanese patients
Authors: Hata Taishi , Umemura Mamoru , Danno Katsuki , Yoshioka Shinichi , Matsuda Chu , Kagawa Yoshinori , Shingai Tatsushi , Suzuki Yozo , Tei Mitsuyoshi , Tanida Tsukasa , Komori Takamichi , Okamura Shu , Ota Hirofumi , Takemoto Hiroyoshi , Ogino Takayuki , Miyoshi Norikatsu , Yamamoto Hirofumi , Murata Kohei , Doki Yuichiro , Eguchi Hidetoshi 
Published: July 2024

Abstract

Adjuvant oxaliplatin plus capecitabine (XELOX) therapy is recommended for patients with curatively resected colon cancer. However, prospective data on its practical application in Japanese patients are limited. Therefore, this study aims to conduct a long-term clinical evaluation of the efficacy and safety of adjuvant XELOX in patients with curatively resected stage III colon cancer (MCSCO-1024). This prospective, multicenter, open-label, single-arm phase II study enrolled patients with curatively resected stage III colon cancer. The treatment protocol comprised a 120-minute intravenous infusion of oxaliplatin (130 mg/m2) on day 1 and two divided doses of oral capecitabine (2000 mg/m2/day) for 14 days in a 3-week cycle, totaling eight cycles (24 weeks). The primary endpoint was 3-year disease-free survival (DFS), and the secondary endpoints were 5-year overall survival and long-term prognosis of peripheral sensory neuropathy. In total, 196 patients were enrolled between November 2011 and August 2014 (34 months). The 3-year DFS rate was 73%, and the 5-year overall survival rate was 87%. The overall incidence of peripheral sensory neuropathy was 17%, with a 1% rate of grade 3 neuropathy after 5 years. Adjuvant XELOX demonstrated utility and safety in the clinical management of Japanese patients with stage III colon cancer.
Innate immune signatures in the nasopharynx after SARS-CoV-2 Infection and links with the clinical outcome of COVID-19 in Omicron-dominant period
Authors: Cha Hyunkyung , Lee Chan Mi , Kim Sujin , Kang Chang Kyung , choe Pyoeng Gyun , Jeon Yoon-Kyung , Jo Hyeon Jae , Kim Nam Joong , Park Wan Beom , Kim Hyun Jik 
Published: July 2024

Abstract

While severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is characterized by impaired induction of interferons (IFNs) and IFN-stimulated genes (ISGs), the interferons (IFNs) and IFN-stimulated genes (ISGs) in upper airway is essential to restrict the spread of respiratory virus. Here, we identified the prominent IFN and ISG upregulation in the nasopharynx (NP) of mild and even severe COVID-19 patients (CoV2+) in Omicron era and to compare their clinical outcome depending on the level of IFNs and ISGs. Whereas the induction of IFNB was minimal, transcription of IFNA, IFNG, and IFNLs was significantly increased in the NP of CoV2 + patients. IFNs and ISGs may be more upregulated in the NP of CoV2 + patients at early phases of infection according to viral RNA levels and this is observed even in severe cases. IFN-related innate immune response might be characteristic in macrophages and monocytes at the NP and the CoV2 + patients with higher transcription of IFNs and ISGs in the NP showed a correlation with good prognosis of COVID-19. This study presents that IFNs and ISGs may be upregulated in the NP, even in severe CoV2 + patients depending on viral replication during Omicron-dominant period and the unique IFN-responsiveness in the NP links with COVID-19 clinical outcomes.
Characteristics of incident coronary artery disease in patients undergoing atrial fibrillation ablation
Authors: Ikeda Hiroyuki , Hasegawa Kanae , Uzui Hiroyasu , Mukai Moe , Tama Naoto , Ishida Kentaro , Tada Hiroshi 
Published: July 2024

Abstract

Background
Few reports have provided detailed characteristics of incident coronary artery disease and its risk factors in patients undergoing ablation for atrial fibrillation..
Methods
Patients undergoing ablation for atrial fibrillation with no documented coronary artery disease were retrospectively studied at our institution. Patients were divided into two groups: those in whom significant stenosis was detected incidentally on coronary angiography performed at the same time as ablation and those in whom it was not, and the detection rate and its predictors were examined.
Results
Of the 550 patients, 30 patients showed incidental coronary artery disease (CAD) (detection rate: 3.6%). We compared clinical data between these 30 patients (ABL-CAD group) and the 520 patients (ABL-non-CAD group) who displayed no significant stenosis on coronary angiography. In multivariate analysis, age, hemoglobinA1c (HbA1c) and high-density lipoprotein cholesterol (HDL-chol.) were predictive factors (odds ratio: 1.08, 2.43, 1.58, 95% CI: 1.01–1.14, 1.53–3.86, 0.92–0.99, P value: 0.014, 0.004, 0.024, respectively) for identification of CAD. Multivariate analysis based on cut-off values from receiver operating characteristic analysis identified age, HbA1c ≥ 6.1%, HDL ≤ 49 mg/dL as predictors (odds ratios: 1.06, 4.04, 3.07; 95% confidence intervals [CIs]: 1.00–1.12, 1.58–10.3, 1.18–8.01; P = 0.04, P < 0.01, P = 0.021, respectively). Area under the curve was significantly greater for age plus HbA1c ≥ 6.1% plus HDL ≤ 49 mg/dL (0.810) than for age alone (0.672; P = 0.005).
Conclusion
Patients undergoing ablation for atrial fibrillation appear likely to have CAD if HbA1c is ≥ 6.1% and HDL-chol is ≤ 49 mg/dL.
A Comparison of Yoga and Clinical Pilates Exercise Methods in Women with Breast Cancer-Related Lymphedema: A Randomized Controlled Trial
Authors: Zabit Ferdiye , Iyigun Gozde , Malkoc Mehtap 
Published: July 2024

Abstract

Purpose: This study conducted a comparison of the benefits of yoga and clinical Pilates exercise methods, both administered with compression stockings, on lymphedema, muscle strength, upper extremity functions, and quality of life in women with BCRL
Methods: 28 individuals with breast cancer-related lymphedema were included in the study. The upper extremity lymphedema severity of the individuals was evaluated by circumference and volumeter measurement. Upper extremity muscle strength was measured with an isokinetic dynamometer (HUMAC/NORM Testing & Rehabilitation System, CSMD). The disabilities of the arm, shoulder, and hand (DASH) questionnaire was used to evaluate upper extremity functions, and the Breast Cancer-Specific Quality of Life Questionnaire (QLQ-BR23) was used to evaluate the quality of life.
Results: In our study, it was determined that compared to pre-treatment, the severity of lymphedema decreased more in the yoga and clinical Pilates groups than in the control group (P4 = .034). In extremity with lymphedema (EwLE), the clinical Pilates group had the greatest improvement in muscular strength for internal rotation (IR) (P3=.016, P4=.037), while the upper extremity functions were shown to be higher in the yoga and clinical Pilates groups compared to the control group (P3=.008, P4=.004). It was found that the quality of life subscale symptom scores, breast symptom (P3=.006, P4=.028) and arm symptom (P2=.004, P3=.008, P4=.002) scores in the yoga group, and arm symptom (P3=.012, P4=.002) scores in the clinical Pilates group showed a positive increase compared to the control group.
Conclusion: Both yoga and clinical Pilates exercises, with the use of compression stockings, have demonstrated favorable results in women with BCRL, showing great potential for treatment. Clinical Pilates exercises have been determined to be useful in several physical aspects, including the reduction of lymphedema, and the improvement of muscle strength and upper extremity functions. On the other hand, the emotional components of quality of life can be effectively improved by yoga exercises.
Trial Registration Number: NCT04824807 ,October 29, 2021
A review of placental histology for infants with hypoxic ischemic encephalopathy compared with healthy controls: A retrospective case-control study
Authors: Fox Aine , Doyle Emma , Reynolds Adam , Geary Michael , Cuzzilla Rocco , Hayes Breda 
Published: July 2024

Abstract

Objective
The role of the placenta in the development of hypoxic ischaemic encephalopathy (HIE) remains undefined. There is limited research comparing placental histology for infants with HIE and healthy controls. This is limiting our ability to understand its role in HIE. This study aimed to report the differences in placental histology between infants with HIE and healthy controls.
Study Design
A case-control study of (near-) term infants with moderate/severe HIE and healthy controls at a single tertiary NICU. Placental histology was reviewed by one perinatal histopathologist using consensus guidelines.
Results
Seventy-four cases and 98 controls were included. Cases had a higher incidence of pathology, including fetal vascular malperfusion, histological chorioamnionitis and delayed villous maturation.
Conclusion
This study demonstrates a higher incidence of placental pathology for infants born with HIE suggesting that the placenta is an important factor in the pathogenesis of HIE. Further research is required to delineate this relationship.
Propionibacterium acnes related endophthalmitis and HFE gene variation
Authors: Gao Ling , Feng Keyi 
Published: July 2024

Abstract

Background
To report a case of propionibacterium acnes endophthalmitis (PAE) associated with HFE gene mutation.
Case presentation
A 44-year-old man presented with painless binocular vision loss 5 months after cataract surgery with a previous diagnosis of binocular retinitis pigmentosa. It was initially diagnosed as noninfectious uveitis and treated with methylprednisolone. One month later, he experienced sudden loss of visual acuity and grey patchy opacity surrounding the capsular and intraocular lens implantation in the left eye. The next generation sequencing testshowed the presence of propionibacterium acnes (PA) in his aqueous humor of a very high sequence. The patient improved after anti-infective treatment. Genetic tests showed mutations in EYS gene and HFE gene.
Conclusion
HFE gene mutation might promote the intraocular growth and reproduction of PA by increasing the concentration of iron ions, leading to PAE in this post-operation patients with normal immune function.
Melt Focusing and Assimilation Along the Lithosphere-Asthenosphere Boundary Beneath Axial Volcano
Authors: Kent Graham , Arnulf Adrien , Singh Satish , Carton Helene , Harding Alistair , Saustrup Steffen 
Published: July 2024

Abstract

Beneath oceanic spreading centres, the lithosphere-asthenosphere boundary (LAB) acts as a permeability barrier that focuses the delivery of melt from deep within the mantle towards the spreading axis1. At intermediate- to fast-spreading ridge crests, the multichannel seismic reflection technique has imaged a nearly flat, 1-2 km wide axial magma lens (AML)2 that defines the uppermost section of the LAB3, but the nature of the LAB deeper into the crust has been more elusive with some clues gained from tomographic images, providing only a diffuse view of a wider halo of lower velocity material seated just beneath the AML4. Here we present three-dimensional (3-D) seismic reflection images of the LAB extending deep (5-6 km) into the crust beneath Axial Volcano, located at the intersection of the Juan de Fuca Ridge and Cobb-Eickelberg Hotspot. The geometry of the LAB is funnel-shaped, representing a magma assimilation front that is thermally-controlled. The morphology of the LAB, in combination with failure surfaces deep within Axial Volcano, highlights the focusing of hotspot- and mid-ocean spreading centre-related magmatism towards the centre of the volcano, controlling both eruption and hydrothermal processes, and the chemical composition of erupted lavas5. Our discovery of a funnel-shaped, crustal LAB suggests that thermally-controlled magma assimilation could be occurring along this surface at other volcanic systems such as Iceland.
Safety and effectiveness of transperineal puncture guided by a biplane intracavitary ultrasonic probe in the treatment of male rectovesical pouch effusion
Authors: Liu Shuqi , Qu Heming , Zhao Xinshu , Wang Peiwen , Teng Deng-Ke , Liu Junzhi 
Published: July 2024

Abstract

The aim of this study was to demonstrate and evaluate the safety and efficacy of transperineal puncture guided by a biplane intracavitary ultrasonic probe in the treatment of male rectovesical pouch effusion in which transabdominal percutaneous access could not be established because of overlying structures. We included fifteen male patients with rectovesical pouch effusion included in this study. The safety of the puncture was evaluated from the occurrence of complications during puncture. For effectiveness, the success rate of one-time puncture and paired t tests were performed to compare the changes in temperature as well as changes in white blood cell count and granulocyte count before and after puncture. We considered a P < 0.05 to indicate statistical significance. The results showed there was a statistically significant difference in the change in temperature as well as the white blood cell count and granulocyte count before and after puncture (P = 0.000, respectively). All patients were successfully treated with one-time transperineal puncture and drainage under the guidance of a biplane intracavitary ultrasonic probe without experienced any complications. Therefore, transperineal puncture guided by a biplane intracavitary ultrasonic probe could be a reliable choice for the treatment of male rectovesical pouch effusion.
Patient Outcomes after Implementation of Transitional Care Protocols In Elective Neurosurgery: A systematic Review and Meta-Analysis
Authors: Aguilera Carlos , Wong Georgia , Khan Ziam , Pivazyan Gnel , Breton Jeffrey M. , Lynes John , Deshmukh Vinay R. 
Published: July 2024

Abstract

Objective
30-day readmissions are a significant burden on the healthcare system. Postoperative transitional care protocols (TCPs) for safe and efficient discharge planning are being more widely adopted to reduce readmission rates. Currently, little evidence exists to justify the utility of TCPs for improving patient outcomes in elective neurosurgery. The objective of this systematic review was to determine the extent to which TCPs reduce adverse outcomes in patients undergoing elective neurosurgical procedures.
Materials and Methods
A systematic review and meta-analysis was conducted after PROSPERO registration. Pubmed, Embase, and Cochrane review databases were searched through February 1, 2024. Keywords included: “transitional care AND neurosurgery”, “Discharge planning AND neurosurgery”. Articles were included if they assessed postoperative TCPs in an adult population undergoing elective neurosurgeries. Exclusion criteria were pediatric patients, implementation of Enhanced Recovery After Surgery (ERAS) protocols, or non-elective neurosurgical procedures. The primary outcome was readmission rates after implementation of TCPs.
Results
16 articles were included in this review. 2 articles found that patients treated with TCPs had significantly higher chances of home discharge. 7 articles found a significant association between implementation of TCP and reduced length of stay and intensive care unit stay. 3 articles reported an increase in patient satisfaction after implementation of TCPs. 3 found that TCP led to a significant decrease in readmissions. After meta-analysis, TCPs were associated with significantly decreased readmission rates (OR: 0.68, p < 0.0001), length of stay (mean difference: -0.57, p < 0.00001), and emergency department visits (OR: 0.33, p < 0.0001)
Conclusions
This systematic review and meta-analysis found that an overwhelming majority of the available literature supports the effectiveness of discharge planning on at least one measure of patient outcomes. However, the extent to which each facet of the TCP affects outcomes in elective neurosurgery remains unclear. Future efforts should be made to compare the effectiveness of different TCPs.
Leishmania infantum in a dog with lymphadenopathy and extensive cutaneous lesions: Hematological, biochemical, cytological and molecular findings
Authors: Yaghoobpour Tina , Rakhshandehroo Ehsan , Sharifiyazdi Hassan , Nematinejad Masoud 
Published: July 2024

Abstract

Leishmania spp., protozoal parasites belonging to the Trypanosomatidae family, are the cause of a common zoonotic illness. Dogs are the main reservoirs of the parasites, which play a considerable role in infecting humans and other hosts. This report explains lymph node involvement by amastigotes of the viscerotropic Leishmania species in a dog who suffered from ulcerative nodules and generalized eczematous and exfoliative dermatitis (erythroderma).
A 2-year-old male dog with evident acute skin lesions and ulcerative nodules on the face was referred to a small animal hospital in Mazandaran province, Iran. The animal had started showing signs ten days prior and was lethargic and lost appetite. In order to detect Leishmania parasites, the popliteal lymph node was sampled for the cytological examination and also polymerase chain reaction (PCR) based on the ITS-1 region of the ribosomal DNA gene. Also, a blood sample was collected to determine hematological and biochemical parameters. As a result, Leishman bodies were seen both inside and outside of macrophages when light microscopy was performed on the lymph node sample stained with Giemsa. Laboratory findings revealed mild leukocytosis, lymphocytosis, neutrophilia, low hematocrit. hyperglobulinemia, hyperproteinemia, hypoalbuminemia, declined albumin/globulin ratio, and hyperglycemia. The PCR and sequencing results confirmed the presence of Leishmania in the popliteal lymph node. According to the molecular analysis, L. infantum was the causative agent of leishmaniasis in this case.
Cutaneous leishmaniasis is prevalent in humans and dogs in Iran. In most cases, L. tropica and L. major are the major causative agents of this form of leishmaniasis, and the lesions are confined. In this report, a generalized skin disease was evident. In addition, hematological and biochemical parameters supported a visceral form of leishmania infection in the animal. Because L. infantum is a more dangerous species than the other types for dogs and specifically humans, our report should be considered to control the infection. This report is significant as this unusual form of visceral leishmaniasis in the dog raises concerns about the possibility of zoonotic transmission and may threaten public health.