bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nomogram combining CT-based radiomic features with clinical features for the differentiation of benign and malignant cystic pulmonary nodules
Authors: Yao Yi , Yang Yanhui , Hu Qiuxia , Xie Xiaoyang , Jiang Wenjian , Liu Caiyang , Li Xiaoliang , Wang Yi , Luo Lei , Li Ji 
Published: June 2024

Abstract
Background
Currently, the differentiation between benign and malignant cystic pulmonary nodules poses a significant challenge for clinicians. The objective of this retrospective study was to construct a predictive model for determining the likelihood of malignancy in patients with cystic pulmonary nodules.

Methods
The current study involved 129 patients diagnosed with cystic pulmonary nodules between January 2017 and June 2023 at the Neijiang First People’s Hospital. The study gathered the clinical data, preoperative imaging features of chest CT, and postoperative histopathological results for both cohorts. Univariate and multivariate logistic regression analyses were employed to identify independent risk factors, from which a prediction model and nomogram were developed. In addition, The model's performance was assessed through receiver operating characteristic (ROC) curve analysis, calibration curve analysis, and decision curve analysis (DCA).

Results
A cohort of 129 patients presenting with cystic pulmonary nodules, consisting of 92 malignant and 37 benign lesions, was examined. Logistic data analysis identified a cystic airspace with a mural nodule, spiculation, mural morphology, and the number of cystic cavities as significant independent predictors for discriminating between benign and malignant cystic lung nodules. The nomogram prediction model demonstrated a high level of predictive accuracy, as evidenced by an area under the ROC curve (AUC) of 0.874 (95% CI: 0.804–0.944). Furthermore, the calibration curve of the model displayed satisfactory calibration. DCA proved that the prediction model was useful for clinical application.

Conclusion
In summary, the risk prediction model for benign and malignant cystic pulmonary nodules has the potential to assist clinicians in the diagnosis of such nodules and enhance clinical decision-making processes.
Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial
Authors: Naik Swati , Li Ying , Talleur Aimee C. , Selukar Subodh , Ashcraft Emily , Cheng Cheng , Madden Renee M. , Mamcarz Ewelina , Qudeimat Amr , Sharma Akshay , Srinivasan Ashok , Suliman Ali Y. , Epperly Rebecca , Obeng Esther A. , Velasquez M. Paulina , Langfitt Deanna , Schell Sarah , Métais Jean-Yves , Arnold Paula Y. , Hijano Diego R. , Maron Gabriela , Merchant Thomas E. , Akel Salem , Leung Wing , Gottschalk Stephen , Triplett Brandon M. 
Published: June 2024

Abstract
Background
Relapse remains a challenge after transplantation in pediatric patients with hematological malignancies. Myeloablative regimens used for disease control are associated with acute and long-term adverse effects. We used a CD45RA-depleted haploidentical graft for adoptive transfer of memory T cells combined with NK-cell addback and hypothesized that maximizing the graft-versus-leukemia (GVL) effect might allow for reduction in intensity of conditioning regimen.

Methods
In this phase II clinical trial (NCT01807611), 72 patients with hematological malignancies (complete remission (CR)1: 25, ≥ CR2: 28, refractory disease: 19) received haploidentical CD34 + enriched and CD45RA-depleted hematopoietic progenitor cell grafts followed by NK-cell infusion. Conditioning included fludarabine, thiotepa, melphalan, cyclophosphamide, total lymphoid irradiation, and graft-versus-host disease (GVHD) prophylaxis consisted of a short-course sirolimus or mycophenolate mofetil without serotherapy.

Results
The 3-year overall survival (OS) and event-free-survival (EFS) for patients in CR1 were 92% (95% CI:72–98) and 88% (95% CI: 67–96); ≥ CR2 were 81% (95% CI: 61–92) and 68% (95% CI: 47–82) and refractory disease were 32% (95% CI: 11–54) and 20% (95% CI: 6–40). The 3-year EFS for all patients in morphological CR was 77% (95% CI: 64–87) with no difference amongst recipients with or without minimal residual disease (P = 0.2992). Immune reconstitution was rapid, with mean CD3 and CD4 T-cell counts of 410/μL and 140/μL at day + 30. Cumulative incidence of acute GVHD and chronic GVHD was 36% and 26% but most patients with acute GVHD recovered rapidly with therapy. Lower rates of grade III-IV acute GVHD were observed with NK-cell alloreactive donors (P = 0.004), and higher rates of moderate/severe chronic GVHD occurred with maternal donors (P = 0.035).

Conclusion
The combination of a CD45RA-depleted graft and NK-cell addback led to robust immune reconstitution maximizing the GVL effect and allowed for use of a submyeloablative, TBI-free conditioning regimen that was associated with excellent EFS resulting in promising long-term outcomes in this high-risk population.
The trial is registered at ClinicalTrials.gov (NCT01807611).
Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes
Authors: Moadab Fatemeh , Sohrabi Sepideh , Wang Xiaoxing , Najjar Rayan , Wolters Justina C. , Jiang Hua , Miao Wenyan , Romero Donna , Zaller Dennis M. , Tran Megan , Bays Alison , Taylor Martin S. , Kapeller Rosana , LaCava John , Mustelin Tomas 
Published: June 2024

Abstract
Background
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with an unpredictable course of recurrent exacerbations alternating with more stable disease. SLE is characterized by broad immune activation and autoantibodies against double-stranded DNA and numerous proteins that exist in cells as aggregates with nucleic acids, such as Ro60, MOV10, and the L1 retrotransposon-encoded ORF1p.

Results
Here we report that these 3 proteins are co-expressed and co-localized in a subset of SLE granulocytes and are concentrated in cytosolic dots that also contain DNA: RNA heteroduplexes and the DNA sensor ZBP1, but not cGAS. The DNA: RNA heteroduplexes vanished from the neutrophils when they were treated with a selective inhibitor of the L1 reverse transcriptase. We also report that ORF1p granules escape neutrophils during the extrusion of neutrophil extracellular traps (NETs) and, to a lesser degree, from neutrophils dying by pyroptosis, but not apoptosis.

Conclusions
These results bring new insights into the composition of ORF1p granules in SLE neutrophils and may explain, in part, why proteins in these granules become targeted by autoantibodies in this disease.
Effects of Staphylococcus aureus on stem cells and potential targeted treatment of inflammatory disorders
Authors: Liu Zi-xian , Liu Guan-qiao , Lin Ze-xin , Chen Ying-qi , Chen Peng , Hu Yan-jun , Yu Bin , Jiang Nan 
Published: June 2024

AbstractDue to the advanced studies on stem cells in developmental biology, the roles of stem cells in the body and their phenotypes in related diseases have not been covered clearly. Meanwhile, with the intensive research on the mechanisms of stem cells in regulating various diseases, stem cell therapy is increasingly being attention because of its effectiveness and safety. As one of the most widely used stem cell in stem cell therapies, hematopoietic stem cell transplantation shows huge advantage in treatment of leukemia and other blood-malignant diseases. Besides, due to the effect of anti-inflammatory and immunomodulatory, mesenchymal stem cells could be a potential therapeutic strategy for variety infectious diseases. In this review, we summarized the effects of Staphylococcus aureus (S. aureus) and its components on different types of adult stem cells and their downstream signaling pathways. Also, we reviewed the roles of different kinds of stem cells in various disease models caused by S. aureus, providing new insights for applying stem cell therapy to treat infectious diseases.
Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components
Authors: Sheng Xia , Zhang Chunmei , Zhao Jiwei , Xu Jianping , Zhang Peng , Ding Quanju , Zhang Jingfa 
Published: June 2024

AbstractMicrovascular destabilization is the primary cause of the inner blood-retinal barrier (iBRB) breakdown and increased vascular leakage in diabetic retinopathy (DR). Microvascular destabilization results from the combinational effects of increased levels of growth factors and cytokines, involvement of inflammation, and the changed cell-to-cell interactions, especially the loss of endothelial cells and pericytes, due to hyperglycemia and hypoxia. As the manifestation of microvascular destabilization, the fluid transports via paracellular and transcellular routes increase due to the disruption of endothelial intercellular junctional complexes and/or the altered caveolar transcellular transport across the retinal vascular endothelium. With diabetes progression, the functional and the structural changes of the iBRB components, including the cellular and noncellular components, further facilitate and aggravate microvascular destabilization, resulting in macular edema, the neuroretinal damage and the dysfunction of retinal inner neurovascular unit (iNVU). Although there have been considerable recent advances towards a better understanding of the complex cellular and molecular network underlying the microvascular destabilization, some still remain to be fully elucidated. Recent data indicate that targeting the intricate signaling pathways may allow to against the microvascular destabilization. Therefore, efforts have been made to better clarify the cellular and molecular mechanisms that are involved in the microvascular destabilization in DR. In this review, we discuss: (1) the brief introduction of DR and microvascular destabilization; (2) the cellular and molecular components of iBRB and iNVU, and the breakdown of iBRB; (3) the matrix and cell-to-cell contacts to maintain microvascular stabilization, including the endothelial glycocalyx, basement membrane, and various cell–cell interactions; (4) the molecular mechanisms mediated cell–cell contacts and vascular cell death; (5) the altered cytokines and signaling pathways as well as the intricate network of the cytokines involved in microvascular destabilization. This comprehensive review aimed to provide the insights for microvascular destabilization by targeting the key molecules or specific iBRB cells, thus restoring the function and structure of iBRB and iNVU, to treat DR.
Quantitative EEG reactivity induced by electrical stimulation predicts good outcome in comatose patients after cardiac arrest
Authors: Liu Gang , Wang Yuan , Tian Fei , Chen Weibi , Cui Lili , Jiang Mengdi , Zhang Yan , Gao Keming , Su Yingying , Wang Hongxing 
Published: June 2024

AbstractBackgroundEEG reactivity is a predictor for neurological outcome in comatose patients after cardiac arrest (CA); however, its application is limited by variability in stimulus types and visual assessment. We aimed to evaluate the prognostic value of the quantitative analysis of EEG reactivity induced by standardized electrical stimulation and for early prognostication in this population.MethodsThis prospective observational study recruited post-CA comatose patients in Xuanwu Hospital, Capital Medical University (Beijing, China) between January 2016 and June 2023. EEG reactivity to electrical or traditional pain stimulation was randomly performed via visual and quantitative analysis. Neurological outcome within 6 months was dichotomized as good (Cerebral Performance Categories, CPC 1–2) or poor (CPC 3–5).ResultsFifty-eight post-CA comatose patients were admitted, and 52 patients were included in the final analysis, of which 19 (36.5%) had good outcomes. EEG reactivity induced with the electrical stimulation had superior performance to the traditional pain stimulation for good outcome prediction (quantitative analysis: AUC 0.932 vs. 0.849,p = 0.048). When using the electrical stimulation, the AUC of EEG reactivity to predict good outcome by visual analysis was 0.838, increasing to 0.932 by quantitative analysis (p = 0.039). Comparing to the traditional pain stimulation by visual analysis, the AUC of EEG reactivity for good prognostication by the electrical stimulation with quantitative analysis was significantly improved (0.932 vs. 0.770,p = 0.004).ConclusionsEEG reactivity induced by the standardized electrical stimulation in combination with quantitative analysis is a promising formula for post-CA comatose patients, with increased predictive accuracy.
EU surveys insights: analytical tools, future directions, and the essential requirement for reference materials in wastewater monitoring of SARS-CoV-2, antimicrobial resistance and beyond
Authors: Paracchini Valentina , Petrillo Mauro , Arcot Rajashekar Anandasagari , Robuch Piotr , Vincent Ursula , Corbisier Philippe , Tavazzi Simona , Raffael Barbara , Suffredini Elisabetta , La Rosa Giuseppina , Gawlik Bernd Manfred , Marchini Antonio 
Published: June 2024

Abstract
Background
Wastewater surveillance (WWS) acts as a vigilant sentinel system for communities, analysing sewage to protect public health by detecting outbreaks and monitoring trends in pathogens and contaminants. To achieve a thorough comprehension of present and upcoming practices and to identify challenges and opportunities for standardisation and improvement in WWS methodologies, two EU surveys were conducted targeting over 750 WWS laboratories across Europe and other regions. The first survey explored a diverse range of activities currently undertaken or planned by laboratories. The second survey specifically targeted methods and quality controls utilised for SARS-CoV-2 surveillance.

Results
The findings of the two surveys provide a comprehensive insight into the procedures and methodologies applied in WWS. In Europe, WWS primarily focuses on SARS-CoV-2 with 99% of the survey participants dedicated to this virus. However, the responses highlighted a lack of standardisation in the methodologies employed for monitoring SARS-CoV-2. The surveillance of other pathogens, including antimicrobial resistance, is currently fragmented and conducted by only a limited number of laboratories. Notably, these activities are anticipated to expand in the future. Survey replies emphasise the collective recognition of the need to enhance the accuracy of results in WWS practices, reflecting a shared commitment to advancing precision and effectiveness in WWS methodologies.

Conclusions
These surveys identified a lack of standardised common procedures in WWS practices and the need for quality standards and reference materials to enhance the accuracy and reliability of WWS methods in the future. In addition, it is important to broaden surveillance efforts beyond SARS-CoV-2 to include other emerging pathogens and antimicrobial resistance to ensure a comprehensive approach to protecting public health.
Association between DASH diet and asthma symptoms among a large sample of adolescents: a cross-sectional study
Authors: Arabi Vahid , Sasanfar Bahareh , Toorang Fatemeh , Nafei Zahra , Behniafard Nasrin , Salehi-Abargouei Amin 
Published: June 2024

Abstract
Background
The Dietary Approaches to Stop Hypertension (DASH) diet, which has a lot of emphasis on the consumption of fruits, vegetables, and whole grains, and on the other hand, the consumption of red meat and sodium is limited, due to its anti-inflammatory properties, which can be related to reducing the risk of asthma.

Objectives
The aim of this study was to determine the relationship between the DASH diet and asthma symptoms among children and adolescents.

Methods
This cross-sectional study was conducted among7667 children (3414 boys and 4253 girls) aged 6–7 and 13–14 years living in central Iran. Dietary food consumption was assessed using a multiple-choice questionnaire. Logistic regression was used to obtain odds ratios for the association between the DASH-like diet with current asthma and asthma symptoms.

Results
Our findings revealed that higher adherence to a DASH-like diet resulted in lower odds of asthma confirmed by a doctor among the whole population (OR = 0.53; 95%CI: 0.36–0.76) and also in females (OR = 0.47; 95%CI: 0.29–0.78). Moreover, the higher adherence to the DASH-like diet was inversely associated with the chance of wheezing in the past 12 months in all subjects (OR = 0.67; 95%CI: 0.51–0.86) and in boys (OR = 0.57; 95%CI: 0.38–0.85).

Conclusion
The findings of the present study showed that following the DASH diet can be associated with the improvement of asthma symptoms in children and adolescents. However, more research is needed to improve dietary recommendations for asthma prevention.
Mid-Treatment Response to 177-Lutetium Dotatate Predicts Overall Outcome in Patients With Advanced Neuroendocrine Tumors
Authors: Halperin Reut , Tirosh Amit 
Published: June 2024

PURPOSE
Patients with advanced, well-differentiated neuroendocrine tumors (WD-NETs) often require both peptide receptor radionuclide therapy (PRRT) and subsequent chemotherapy. However, no mid-PRRT predictors are available to identify patients who will not benefit from subsequent PRRT to limit their radiation exposure. Our aim is to characterize patients for whom subsequent PRRT is less efficacious on the basis of mid-PRRT evaluation.

MATERIALS AND METHODS

A retrospective study of patients with WD-NET who underwent ≥four PRRT cycles. Data gathered included demographics, tumor grade, stage, and response (partial response [PR], stable disease [SD], and progressive disease [PD]) on the basis of RECIST 1.1 criteria and
68
Ga-dotatate positron emission tomography-computerized tomography pretreatment, after second and fourth treatment cycle, 6 months after fourth cycle, and at last follow-up.

RESULTS

Fifty-one patients (51.6% women; age at diagnosis 66.0 ± 1.65 years), with pancreatic NET (PNET; n = 24), small intestine NET (n = 13), or other NET (n = 14), received PRRT, resulting in PR (n = 21), SD (n = 23), and PD (n = 3). Of the patients reaching PR after PRRT, most reached PR after two treatments (70.4%), with only 11.8% PR occurring between subsequent cycles (
P
= .001). Furthermore, patients with PR at mid-treatment had higher PR rates after PRRT completion than those with SD (
P
= .007). Patients harboring PNET who achieved PR had a more pronounced reduction of tumor burden in additional cycles than patients who did not (25.6%
v
1.5%;
P
= .03, respectively). On the multivariable model, adjusted for grade and primary site, PR at mid-treatment evaluation was associated with a 20.9 adjusted odds ratio for additional PR at PRRT completion (
P
= .002).

CONCLUSION
Mid-PRRT assessment predicts subsequent PRRT response in patients with WD-NET, especially those with PNET, informing personalized management and consideration of reduced bone marrow radiation exposure in high-risk patients.
Notes Toward a Theoretical History of Indic Media
Authors: Thirumal P. , P Narmada , Chintakunta Himabindu 
Published: June 2024

Abstract
This study demonstrates how Brahminic embodiment provides a constraining milieu for the growth of technology in different historical and epistemic epochs. Brahmanic comportment allows for appropriating technology in a way that creates a historical continuity with an auratic past and disallows the agential power of technology to extinguish the spirit of the Indic auratic past. In effect, Brahmanic comportment disallows technological advancement and human flourishing.
Physiological activity, severity of neurotic symptoms and personality traits of patients in a
psychiatric day ward in the initial and final phases of the psychodynamic psychotherapy process. Quasi-longitudinal pilot study.
Authors: Konop Magdalena Anna , Sobański Jerzy , Klasa Katarzyna , Mielimąka Michał , Dembińska Edyta , Rutkowski Krzysztof 
Published: June 2024

Aim of the studyThe aim of the study was to explore HR (heart rate) and EDA (electrodermal activity) activity of patients in the initial and final phase of a 12-week psychodynamic psychotherapy process. The physiological data obtained were corelated with psychological variables (questionnaire results of patients).Subject or material and methodsData from 12 patients with a diagnosis of neurotic disorders and/or personality disorders were analysed. Patients were examined with the MMPI-2 (Minnesota Multiphasic Personality Inventory), KON-2006 (Neurotic Personality Questionnaire) and Symptom Checklist "O". Physiological data were collected using a galvanometer and a pulsometer.ResultsThe results of psychological questionnaires in the final phase of psychotherapy showed a reduction in symptoms in most of the scales compared to the initial questionnaires. Patients' EDA and HR scores decreased in the final phase of psychotherapy compared to the initial phase. Most of scores of personality disorder traits showed a negative correlation with EDA and a positive correlation with HR, neurotic personality traits correlated positively with EDA and negatively with HR. At the end of the psychotherapy process, a positive correlation was observed between personality traits and physiological measures.DiscussionThe obtained results suggest that psychotherapy can lower the intensity of the physiological activity of patients. Psychotherapy probably has the potential to change the direction of physiological responses of patients with personality disorder traits.ConclusionsPhysiological activity can potentially be used as an objective measure of the effectiveness of psychotherapy. The study should be repeated on a larger group of subjects to confirm the results we obtained.
Efficient Project Scheduling with Autonomous Learning Opportunities
Authors: Hill Alessandro , Vossen Thomas W. M. 
Published: June 2024

We consider novel project scheduling problems in which the experience gained from completing selected activities can be used to accelerate subsequent activities. Given a set of potential learning opportunities, our model aims to identify the opportunities that result in a maximum reduction of the project makespan when scheduled in sequence. Accounting for the impact of such learning opportunities causes significant complications, due to the cyclic nature of the learning relations and their interference with the precedence network. We propose additive and subtractive algorithms that iteratively reschedule the project using an enhanced topological sorting algorithm. Learning opportunities are integrated, activated, and potentially deactivated in each step by maintaining the acyclicity of the combined precedence and learning network. To illustrate the challenges that arise in this setting, we first consider the special case where activities can learn from at most one other activity. Subsequently, we extend our approach to the general case that admits multiple learning opportunities. We show that our approaches guarantee the construction of an optimal solution in polynomial time. In a computational study using 340 small and large resource-unconstrained PSPlib instances, we analyze the model behavior under various scenarios of learning intensity and learning opportunity. We demonstrate that significant project speedups can be obtained when proactively accounting for learning opportunities. History: Accepted by Pascal van Hentenryck, Area Editor for Computational Modeling: Methods & Analysis. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.0107 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0107 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .