bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the Children's Oncology Group's supportive care clinical practice guideline endorsement program: An institutional survey
Authors: Marchak Jordan Gilleland , Beauchemin Melissa P. , Broglie Larisa , Kelly Katherine Patterson , Seelisch Jennifer , Dupuis L. Lee ,   the Children's Oncology Group Supportive Care Guidelines Task Force
Published: July 2024

AbstractBackgroundSupportive care clinical practice guidelines (CPGs) facilitate the incorporation of the best available evidence into pediatric cancer care. We aimed to assess the impact of the work of the Children's Oncology Group (COG) Supportive Care Guideline Task Force on institutional supportive care practices.ProcedureAn online survey was distributed to representatives at 209 COG sites to assess the awareness, use, and helpfulness of COG‐endorsed supportive care CPGs. Availability of institutional policies regarding 13 topics addressed by current COG‐endorsed CPGs was also assessed. Respondents described their institutional processes for developing supportive care policies.ResultsRepresentatives from 92 COG sites responded to the survey, and 78% (72/92) were “very aware” of the COG‐endorsed supportive care CPGs. On average, sites had policies that addressed seven COG‐endorsed supportive care CPG topics (median = 7, range: 0‐12). Only 45% (41/92) of sites reported having institutional processes for developing supportive care policies. Of these, most (76%, 31/41) reported that the COG‐endorsed CPGs have a medium or large impact on policy development. Compared with sites without processes for supportive care policy development, sites with established processes had policies on a greater number of topics aligned with current COG‐endorsed CPG topics (mean = 6.6, range: 0‐12 vs mean = 7.9, range: 2‐12; p = 0.027).ConclusionsMost site respondents were aware of the COG‐endorsed supportive care CPGs. Less than half of the COG sites represented in the survey have processes in place to implement supportive care policies. Improvement in local implementation is required to ensure that patients at COG sites receive evidence‐based supportive care.
Emergency department 30‐Day emergency department revisits among people with sickle cell disease: Variations in characteristics
Authors: Rushing Melinda , Horiuchi Sophia , Zhou Mei , Kavanagh Patricia L. , Reeves Sarah L. , Snyder Angela , Paulukonis Susan 
Published: July 2024

AbstractPeople with sickle cell disease (SCD) often have emergency department (ED) revisits. The characteristics of people with SCD with ED revisits were assessed in this study using Medicaid administrative claims data from California and Georgia, representing 2794 and 3641 individuals with SCD, respectively. In both states, those with 6+ primary care provider (PCP) encounters had the highest percentage of ED revisits. In California, those with 6+ hematology encounters had the lowest percentage of individuals with an ED revisit; in Georgia, those with 1‐2 hematology encounters. Increasing access to hematologic care may reduce ED revisits among people with SCD.
Long‐term outcomes among survivors of childhood osteosarcoma: A report from the Childhood Cancer Survivor Study (CCSS)
Authors: Becktell Kerri , Chen Yan , Yasui Yutaka , Phelan Rachel , Armstrong Gregory T. , Link Michael , Oeffinger Kevin , Snyder Claire , Daw Najat , Weil Brent , Weldon Christopher , Chow Eric J. , Schwartz Cindy L. 
Published: July 2024

AbstractPurposeTreatment strategies for osteosarcoma evolving between 1970 and 1999 improved 5‐year survival and continue as standard of care today. This report evaluates the impact of these evolving therapies on long‐term health outcomes.MethodsFive‐year survivors of childhood osteosarcoma in CCSS treated from 1970 to 1999 were evaluated for late (>5 years from diagnosis) mortality, chronic health conditions (CHCs), and health status using piecewise‐exponential and logistical models. Comparisons were made between survivors and siblings without cancer, and among survivors examining historical and current standard chemotherapies (e.g., methotrexate/doxorubicin/cisplatin [MAP] vs. others), specific chemotherapy agents and surgical approaches (amputation vs. limb salvage [LS]). Models were evaluated adjusting for attained age, sex, race, ethnicity, and age at diagnosis.ResultsA total of 1257 survivors of osteosarcoma were followed on average for 24.4 years. Twenty‐year all‐cause late mortality was 13.3% (95% confidence interval [CI]: 11.7%–14.9%) overall and 11.7% (95% CI: 6.9%–16.5%) for the subset treated with MAP plus LS. Survivors were at higher risk of CHCs (rate ratio [RR] 3.7, 95% CI: 3.2–4.3) than the sibling cohort, most notably having more serious cardiac, musculoskeletal, and hearing CHCs. Within the survivor cohort, the risk of severe CHCs was twice as high with MAP versus no chemotherapy (RR 2.1, 95% CI: 1.3–3.4). Compared with primary amputation, serious musculoskeletal CHCs were higher after LS (RR 6.6, 95% CI: 3.6–13.4), without discernable differences in health status.ConclusionContemporary osteosarcoma therapy with MAP plus LS, while improving 5‐year disease‐free survival, continues to be associated with a high burden of late mortality, CHCs, and health status limitations.
Miniprotein engineering for inhibition of PD‐1/PD‐L1 interaction
Authors: Ciesiołkiewicz Agnieszka , Lizandra Perez Juan , Skalniak Lukasz , Noceń Paweł , Berlicki Łukasz 
Published: July 2024

AbstractMiniproteins constitute an excellent basis for the development of structurally demanding functional molecules. The engrailed homeodomain, a three‐helix‐containing miniprotein, was applied as a scaffold for constructing programmed cell death protein 1/programmed death‐ligand 1 (PD‐1/PD‐L1) interaction inhibitors. PD‐L1 binders were initially designed using the computer‐aided approach and subsequently optimized iteratively. The conformational stability was assessed for each obtained miniprotein using circular dichroism spectroscopy, indicating that numerous mutations could be introduced. The formation of a sizable hydrophobic surface at the inhibitor that fits the molecular target imposed the necessity for the incorporation of additional charged amino acid residues to retain its appropriate solubility. Finally, the miniprotein effectively binding to PD‐L1 (KD = 51.4 nM) that inhibits PD‐1/PD‐L1 interaction in cell‐based studies with EC50 = 3.9 μM, was discovered.
Separation and Evaluation of the Gradient Relaxation in the Atomic Comagnetometer
Authors: Yuan Linlin , Duan Lihong , Gao Hang , Cai Ze , Zhang Kai , Huang Jiong , Liu Sixun , Wang Zhuo , Liu Feng , Quan Wei 
Published: July 2024

AbstractIn the atomic comagnetometer, nuclear spin relaxation is a core parameter that affects the magnetic field suppression ability and stability, and is influenced by various gradient fields. It is necessary to measure and separate the effects of different gradients on nuclear spin, which helps to effectively suppress them separately. This article proposes a periodic optical pumping method for separating and measuring polarization gradient relaxation and magnetic field gradient relaxation, considering the effects of pump light and applied magnetic field. The comprehensive influence model for pump light on transverse nuclear spin relaxation is established, and the measurement steps and parameter selection criteria for the proposed method considering signal decay characteristics are provided. Furthermore, the proportion of various gradient relaxations is quantified. This work provides an evaluation method for gradient relaxation suppression, supporting the improvement of the measurement sensitivity and stability of the atomic comagnetometer.
The role of local bounds on neighborhoods in the network for scale‐free state synchronization of multi‐agent systems
Authors: Stoorvogel Anton A. , Saberi Ali , Liu Zhenwei 
Published: July 2024

AbstractThis article provides necessary and sufficient conditions for the existence of solutions to the state synchronization problem of homogeneous multi‐agent systems (MAS) via scale‐free linear dynamic non‐collaborative protocol in both continuous and discrete time. These conditions guarantee for which class of MAS, one can achieve scale‐free state synchronization. We investigate protocol design with and without utilizing local bounds on the neighborhood of agents. The results shows that the availability of local bounds on neighborhoods plays a key role.
Model‐free event‐triggered distributed coordination control for dual‐arm reconfigurable manipulators with unknown object constraints
Authors: Li Yuanchun , Fan Ruiming , Pan Qiang , An Tianjiao , Zhu Mingchao , Ma Bing 
Published: July 2024

AbstractIn this paper, a model‐free event‐triggered distributed coordination control of dual‐arm reconfigurable manipulators is presented for handling unknown object task. Firstly, based on Newton‐Euler algorithm and kinematic analysis, the dynamic models of the dual‐arm manipulators and grasped object are established, respectively. According to the load distribution method, the motion‐induced force is effectively distributed to each arm. Then the dynamics of single‐arm manipulator for handling task is obtained. Secondly, the adaptive algorithm based on gradient model is proposed to estimate the position of object's center of mass (COM). The fusion state variable function is improved to achieve coordination control, reflecting the tracking performance of the position and internal force. For the modeless reconfigurable manipulator, the radial basis function neural network (RBFNN)‐based observer is utilized to approximate the uncertain dynamics. Further, the aperiodic model‐free distributed coordination controller is obtained through event‐triggered mechanism. Next, the uniformly ultimately bounded (UUB) stability of dual‐arm reconfigurable manipulators system is proved through Lyapunov stability theory. Finally, the experimental results verify that the proposed coordination control approach is valid.
Developing a habitat suitability index with field data and hydraulic models
Authors: Harris Aubrey , Mulchandani Anjali , Stone Mark 
Published: July 2024

AbstractLinking habitat availability with hydraulic models integrates river engineering in the ecological field. Field observation for species presence and physical habitat availability mapping is inherently limited due to time and access constraints for field data collection. This study leverages hydraulic modeling to supplement larval fish population monitoring data, effectively expanding mapped physical habitat and allowing for monitoring bias analysis. The inundation extents and character of streamflow from hydraulic modeling were used to refine habitat suitability indices relative to total habitat availability from discrete fish monitoring events. Given the flexibility in hydraulic modeling to simulate a range of flows, the habitat suitability index is then translated to an effective habitat curve according to areal inundation and hydrologic frequency. With this framework, forecasting the impacts of long‐term trends, such as geomorphic or hydrologic change, can be reasonably and quantitatively assessed. This manuscript uses a case study of Rio Grande silvery minnow monitoring at restoration sites where the floodplain has been lowered via earthwork. Comparisons are made for habitat suitability indices developed from field observation data alone and field observation supplemented by hydraulic modeling. Known biases of field sampling data (targeting slow, shallow areas where fish are most often found) were confirmed based on simulated hydraulic conditions across entire restoration sites. In the case of Rio Grande silvery minnow, a heavily studied species, such field monitoring biases are an effective use of resources. However, this framework may be helpful for assessing alternative management approaches and monitoring strategies of species that are less studied.
Illuminating Pathways to Dynamic Nanotribology: Light‐Mediated Active Control of Interfacial Friction with Nanosuspensions
Authors: Leidens Leonardo M. , Michels Alexandre F. , Machado Giovanna , Alvarez Fernando , Smirnov Alex I. , Krim Jacqueline , Figueroa Carlos A. 
Published: July 2024

AbstractActive control of nanotribological properties is a challenge. Materials responsive to external stimuli may catalyze this paradigm shift. Recently, the nanofriction of a thin film is modulated by light, ushering in phototribology. This frontier is expanded here, by investigating photoactive nanoparticles in lubricants to confer similar functionality to passive surfaces. Quartz‐crystal microbalance (QCM) is employed to assess the phototribological behavior of aqueous suspensions of titanium dioxide nanoparticles. A comparison of dark and illuminated conditions provides the first demonstration of tuning the interfacial friction in solid‐nanosuspension interfaces by light. Cyclic tests reveal reversible transitions between higher (dark) and lower friction (illuminated) regimes. These transitions are underpinned by transient states with surface charge variations, as confirmed by Zeta potential measurements. The accumulated surface charge increases repulsion within the system and favors sliding. Upon cessation of illumination, the system returns to its prior equilibrium state. These findings impact not only nanotribology but nanofluidics and nanorheology. Furthermore, the results underscore the need to consider light‐induced effects in other scenarios, including the calculation of activity coefficients of photoactive suspensions. This multifaceted study introduces a new dimension to in operando frictional tuning, beckoning a myriad of applications and fundamental insights at the nanoscale.
Nanocarbon catalysts with co‐active S−P−C sites enhance metal‐free direct oxidation of alcohols
Authors: Meng Juan , Liu Huidong , Xu Jianing , Lou Yuhan , Sun Haixin , Jiang Bo , Liu Yongzhuang , Qin Hengfei , Dou Shuo , Yu Haipeng 
Published: July 2024

AbstractIn this study, a sulfur–phosphorus co‐doped nanocarbon (SPC) catalyst was synthesized using a straightforward one‐step colloidal carbonization method and demonstrated high performance in the metal‐free direct oxidation of alcohols to aldehydes. This metal‐free SPC catalyst showed exceptional efficiency, achieving a conversion rate of 90% for benzyl alcohol and a selectivity of 94% toward benzaldehyde within only 1 h at 130°C. Moreover, it displays exceptional cycle stability and a high turnover frequency (17.1 × 10−3 mol g−1 h−1). Theoretical analysis suggested that the catalyst's superior performance is attributed to the presence of unsaturated edge defects and S−P− moieties, which increase the density of states at the Fermi level, lower the band gap energy, and promote electron localization. Additionally, the doping introduces cooperative co‐active S−P−C sites, facilitating a synergistic multisite catalytic effect that lowers the energy barriers. These findings represent a significant advancement in the field of metal‐free direct alcohol oxidation.
Equivariant embedding of finite-dimensional dynamical systems
Authors: Gutman Yonatan , Levin Michael , Meyerovitch Tom 
Published: July 2024

AbstractWe prove an equivariant version of the classical Menger-Nöbeling theorem regarding topological embeddings: Whenever a group G acts on a finite-dimensional compact metric space X, a generic continuous equivariant function from X into $$([0,1]^r)^G$$

(

[
0
,
1
]

r

)

G

is a topological embedding, provided that for every positive integer N the space of points in X with orbit size at most N has topological dimension strictly less than $$\frac{rN}{2}$$

rN

2

. We emphasize that the result imposes no restrictions whatsoever on the acting group G (beyond the existence of an action on a finite-dimensional space). Moreover if G is finitely generated then there exists a finite subset $$F\subset G$$

F
⊂
G

so that for a generic continuous map $$h:X\rightarrow [0,1]^{r}$$

h
:
X
→

[
0
,
1
]

r

, the map $$ h^{F}:X\rightarrow ([0,1]^{r})^{F}$$

h
F

:
X
→

(

[
0
,
1
]

r

)

F

given by $$x\mapsto (f(gx))_{g\in F}$$

x
↦

(
f

(
g
x
)

)

g
∈
F

is an embedding. This constitutes a generalization of the Takens delay embedding theorem into the topological category.
Breast density effect on the sensitivity of digital screening mammography in a UK cohort
Authors: Payne Nicholas R. , Hickman Sarah E. , Black Richard , Priest Andrew N. , Hudson Sue , Gilbert Fiona J. 
Published: July 2024

Abstract
Objectives
To assess the performance of breast cancer screening by category of breast density and age in a UK screening cohort.

Methods
Raw full-field digital mammography data from a single site in the UK, forming a consecutive 3-year cohort of women aged 50 to 70 years from 2016 to 2018, were obtained retrospectively. Breast density was assessed using Volpara software. Examinations were grouped by density category and age group (50–60 and 61–70 years) to analyse screening performance. Statistical analysis was performed to determine the association between density categories and age groups. Volumetric breast density was assessed as a binary classifier of interval cancers (ICs) to find an optimal density threshold.

Results
Forty-nine thousand nine-hundred forty-eight screening examinations (409 screen-detected cancers (SDCs) and 205 ICs) were included in the analysis. Mammographic sensitivity, SDC/(SDC + IC), decreased with increasing breast density from 75.0% for density a (p = 0.839, comparisons made to category b), to 73.5%, 59.8% (p = 0.001), and 51.3% (p < 0.001) in categories b, c, and d, respectively. IC rates were highest in the densest categories with rates of 1.8 (p = 0.039), 3.2, 5.7 (p < 0.001), and 7.9 (p < 0.001) per thousand for categories a, b, c, and d, respectively. The recall rate increased with breast density, leading to more false positive recalls, especially in the younger age group. There was no significant difference between the optimal density threshold found, 6.85, and that Volpara defined as the b/c boundary, 7.5.

Conclusions
The performance of screening is significantly reduced with increasing density with IC rates in the densest category four times higher than in women with fatty breasts. False positives are a particular issue for the younger subgroup without prior examinations.

Clinical relevance statement
In women attending screening there is significant underdiagnosis of breast cancer in those with dense breasts, most marked in the highest density category but still three times higher than in women with fatty breasts in the second highest category.

Key Points

Breast density can mask cancers leading to underdiagnosis on mammography.

Interval cancer rate increased with breast density categories ‘a’ to ‘d’; 1.8 to 7.9 per thousand.

Recall rates increased with increasing breast density, leading to more false positive recalls.
Shifts from surface density compensation to projected warming, freshening and stronger stratification in the subpolar North Atlantic
Authors: Marsh Robert , Dey Dipanjan , Lenn Yueng-Djern , Roberts Emyr Martyn 
Published: July 2024

AbstractThe hydrography and stratification of the subpolar North Atlantic is highly variable, with convection activating and deactivating across parts of the Labrador and Irminger seas. Likely consequential for the Atlantic Meridional Overturning Circulation (AMOC), this variability is examined in an eddy-rich ocean model hindcast spanning 1958–2021 and in 1950–2050 simulations with four climate models, spanning differences in ocean resolution (eddy-rich or eddy-permitting), code and implementation. Stratification of the Labrador and Irminger seas is quantified with the Potential Energy Anomaly (PEA) in the upper 1000 m of the water column. Monthly PEA anomalies are evaluated alongside corresponding anomalies of sea surface temperature, salinity, and density. For 30-year windows, moving correlations between PEA and surface properties are obtained over the 100-year simulations to characterize the evolving relationships. As climate change progresses, stratification in three of the four models is increasingly associated with variable surface salinity, in both regions. Lagrangian analyses of surface flow pathways in the decades preceding 1990 and 2040 are undertaken for one of the models in which surface salinity grows in influence. The subpolar presence of low-salinity Arctic waters and high-salinity subtropical Atlantic waters are found to increase and decrease respectively by 2040. Furthermore, in three of the four models, surface density compensation associated with correlation of surface temperature and salinity anomalies is progressively replaced by combined surface warming and freshening, lowering surface density, and strengthening stratification. The extent of these model-dependent changes and processes are of consequence for the projected fate of the AMOC by the mid twenty-first century.
Bile lakes in patients with biliary atresia who presented with jaundice-free native liver survival indicating the risk of subsequent liver transplantation due to various factors
Authors: Gohda Yousuke , Uchida Hiroo , Sumida Wataru , Shirota Chiyoe , Tainaka Takahisa , Makita Satoshi , Satomi Miwa , Yasui Akihiro , Kato Daiki , Maeda Takuya , Ishii Hiroki , Ota Kazuki , Guo Yaohui , Liu Jiahui , Hinoki Akinari 
Published: July 2024

Abstract
Purpose
The prognostic factors of subsequent liver transplantation (LT) in patients with biliary atresia (BA) who presented with jaundice-free native liver survival were investigated.

Methods
This study retrospectively reviewed patients who underwent portoenterostomy (PE) for BA. Patients with jaundice-free native liver survival at 1 year postoperatively were divided into the autologous liver survivor and liver transplant recipient groups. Peri- and postoperative data were compared between the two groups.

Results
Among 97 patients with BA, 29 who received LT within 1 year after PE were excluded from the analysis. Further, 48 patients currently living with native liver and 20 who received LT after 1 year postoperatively were compared. Bile lake (BL) was the strongest risk factor of LT. The risk score was $$2.38*BLscore+0.00466*TBA$$

2.38

∗
B
L
s
c
o
r
e
+
0.00466

∗
T
B
A

, and the area under the receiver operating characteristic curve was 0.83. Patients with BL and those without significantly differed in terms of the native liver survival rate. Patients with BL who presented with not only cholangitis but also gastrointestinal hemorrhage and hepatopulmonary syndrome received LT.

Conclusion
BL can cause different pathologies. Moreover, it is an evident risk factor of subsequent LT in patients with BA who are living with native liver at 1 year after PE.