bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near-infrared emitting CdTe0.5Se0.5/Cd0.5Zn0.5S quantum dots: synthesis and bright luminescence
Authors: Yang Ping , Wang Shiquan , Murase Norio 
Published: November 2012

Abstract
We present how CdTe0.5Se0.5 cores can be coated with Cd0.5Zn0.5S shells at relatively low temperature (around 200°C) via facile synthesis using organic ammine ligands. The cores were firstly fabricated via a less toxic procedure using CdO, trioctylphosphine (TOP), Se, Te, and trioctylamine. The cores with small sizes (3.2-3.5 nm) revealed green and yellow photoluminescence (PL) and spherical morphologies. Hydrophobic core/shell CdTe0.5Se0.5/Cd0.5Zn0.5S quantum dots (QDs) with tunable PL between green and near-infrared (a maximum PL peak wavelength of 735 nm) were then created through a facile shell coating procedure using trioctylphosphine selenium with cadmium and zinc acetate. The QDs exhibited high PL efficiencies up to 50% because of the formation of a protective Cd0.5Zn0.5S shell on the CdTe0.5Se0.5 core, even though the PL efficiency of the cores is low (≤1%). Namely, the slow growth process of the shell plays an important role for getting high PL efficiencies. The properties of the QDs are largely determined by the properties of CdTe0.5Se0.5 cores and shells preparation conditions such as reaction temperature and time. The core/shell QDs exhibited a small size diameter. For example, the average diameter of the QDs with a PL peak wavelength of 735 nm is 6.1 nm. Small size and tunable bright PL makes the QDs utilizable as bioprobes because the size of QD-based bioprobes is considered as the major limitation for their broad applications in biological imaging.
Assessing the effect of introducing a new method into family planning programs in India, Peru, and Rwanda
Authors: Lundgren Rebecka , Sinai Irit , Jha Priya , Mukabatsinda Marie , Sacieta Luisa , León Federico R 
Published: November 2012

Abstract

Background
Introducing a new method into family planning programs requires careful attention to ensure it meets an actual need and has a positive effect on program goals. The Standard Days Method® is a fertility awareness-based method of family planning that is being introduced into family planning programs in countries around the world. It is different from other methods offered by programs, and may bring new couples into family planning, and increase contraceptive prevalence. The study assesses the effect on contraceptive use and prevalence of Introducing Standard Days Method into existing family planning services in whole regions of India, Peru, and Rwanda.

Methods
In collaboration with the Ministry of Health, health providers were given a contraceptive update on all methods, then trained in counseling on Standard Days Method. Efforts were made to promote demand in the context of informed choice. Routine monthly service statistics in control and intervention areas were used to assess the effect of Standard Days Method introduction at the clinic level; baseline and endline household-based surveys were undertaken to obtain results at the community level (n > 3400 women at endline).

Results
Demand for the method is evident in countries with different levels of contraceptive prevalence. The method attracts couples new to family planning, and introducing it into services may increase overall contraceptive prevalence.

Conclusions
Introducing Standard Days Method into existing family planning has the potential of benefiting men and women in diverse settings and populations. This study illustrates the critical role of evidence in scaling up a health innovation.
Characterization of blood biochemical markers during aging in the Grey Mouse Lemur (Microcebus murinus): impact of gender and season
Authors: Marchal Julia , Dorieux Olène , Haro Laurine , Aujard Fabienne , Perret Martine 
Published: November 2012

Abstract

Background
Hematologic and biochemical data are needed to characterize the health status of animal populations over time to determine the habitat quality and captivity conditions. Blood components and the chemical entities that they transport change predominantly with sex and age. The aim of this study was to utilize blood chemistry monitoring to establish the reference levels in a small prosimian primate, the Grey Mouse Lemur (Microcebus murinus).

Method
In the captive colony, mouse lemurs may live 10–12 years, and three age groups for both males and females were studied: young (1–3 years), middle-aged (4–5 years) and old (6–10 years). Blood biochemical markers were measured using the VetScan Comprehensive Diagnostic Profile. Because many life history traits of this primate are highly dependent on the photoperiod (body mass and reproduction), the effect of season was also assessed.

Results
The main effect of age was observed in blood markers of renal functions such as creatinine, which was higher among females. Additionally, blood urea nitrogen significantly increased with age and is potentially linked to chronic renal insufficiency, which has been described in captive mouse lemurs. The results demonstrated significant effects related to season, especially in blood protein levels and glucose rates; these effects were observed regardless of gender or age and were likely due to seasonal variations in food intake, which is very marked in this species.

Conclusion
These results were highly similar with those obtained in other primate species and can serve as references for future research of the Grey Mouse Lemur.
Severe bleeding tendency caused by a rare complication of excessive fibrinolysis with disseminated intravascular coagulation in a 51-year-old Japanese man with prostate cancer: a case report
Authors: Wada Yoshihiro , Uchiba Mitsuhiro , Kawano Yoshiaki , Kai Nobuyuki , Takahashi Wataru , Honda Jiro , Tanoue Ken-ichiro , Maeda Yoshihiro , Murakami Yoji , Eto Masatoshi , Imamura Takahisa 
Published: November 2012

Abstract

Introduction
Disseminated intravascular coagulation causes thrombotic tendency leading to multiple organ failure and occurs in a wide variety of diseases including malignancy. Disseminated intravascular coagulation is a latent complication in people with prostate cancer.

Case presentation
A 51-year-old Japanese man with advanced castration-resistant prostate cancer was admitted to our hospital because of extensive purpura and severe anemia. Prolonged plasma coagulation time, hypofibrinogenemia and normal platelet count suggested that a decrease in fibrinogen induced a bleeding tendency causing purpura. However, elevated plasma levels of thrombin-antithrombin complex, fibrin and/or fibrinogen degradation products and D-dimers, with positive fibrin monomer test, manifested disseminated intravascular coagulation and subsequent fibrinolysis. Plasma levels of thrombin-antithrombin complex, fibrin and/or fibrinogen degradation products and D-dimers decreased after administration of low-molecular-weight heparin. However, low fibrinogen and α2-antiplasmin levels were not improved and plasmin-antiplasmin complex did not decrease, which revealed excessive fibrinolysis complicated with disseminated intravascular coagulation. We suspected that prostate cancer cell-derived urokinase-type plasminogen activator caused excessive fibrinolysis. Administration of tranexamic acid for fibrinogenolysis was added together with high-dose anti-androgen therapy (fosfestrol) for prostate cancer. Thereafter, prostate-specific antigen and plasmin-antiplasmin complex decreased, followed by normalized fibrinogen and α2-antiplasmin levels, and the patient eventually recovered from the bleeding tendency. Immunohistochemical staining of the biopsied prostate tissue exhibited that the prostate cancer cells produced tissue factor, the coagulation initiator, and urokinase-type plasminogen activator.

Conclusion
This patient with rare complications of disseminated intravascular coagulation and excessive fibrinolysis is a warning case of potential coagulation disorder onset in patients with prostate cancer. We propose that combined administration of tranexamic acid and low-molecular-weight heparin together with high-dose anti-androgen therapy is a useful therapeutic option for patients with this complicated coagulation disorder.
Good workers for good jobs: improving education and workforce systems in the US
Authors: Holzer Harry J 
Published: November 2012

AbstractStagnant earnings and growing inequality in the US labor market reflect both a slowdown in the growth of worker skills and the growing matching of good-paying jobs to skilled workers. Improving the ties between colleges, workforce institutions, and employers would help more workers gain the needed skills. Evaluation evidence shows that training programs linked to employers and good-paying jobs are often cost-effective. Helping more states develop such programs and systems would help raise worker earnings and reduce inequality.
Electrochemical determination of calcium channel blocker drugs using multiwall carbon nanotube-modified glassy carbon electrode
Authors: Sikkander Abdul Razak Mohamed , Vedhi Chinnappiyan , Manisankar Paramasivam 
Published: November 2012

Abstract

Background
Calcium channel blockers belonging to the dihydropyridine family have been used as a potent arterial vasodilator in the management of angina and cardiovascular diseases. In the design of glassy carbon electrode coatings for the study of the same, multiwall carbon nanotubes (MWCNT) are favored. They are known for the reduction and oxidation of electroactive species towards cathodic and anodic direction with the simultaneous enhancement of the peak current.

Results
The MWCNT-modified glassy carbon electrode exhibited a sharp anodic peak potential at around at 0.5 V for amlodipine (AMLD) andnimodipine (NIMD), and 0.4 V for felodipine (FELD) in the cyclic voltammograms. The antihypertensive drugs were determined using a simple two-step procedure developed which comprised a preconcentration step followed by the differential pulse stripping voltammetric quantification. Concentration calibrations were linear within the range from 0.01 to 0.3 μg/mL for AMLD and FELD, and 0.025 to 0.3 μg/mL for NIMD.

Conclusion
The lower limit detection (LOD) was found to be very low on modified electrode. The LOD is 0.005 μg/mL for AMLD and FELD, and 0.01 μg/mL for NIMD. The prepared electrode showed an excellent electrocatalytic activity towards the oxidation of antihypertensive drugs leading to a remarked improvement in sensitivity. An electrochemical sensor featuring the MWCNT-modified electrode was applied successfully as the result for the calcium channel blocker determination in pharmaceutical samples.
Gonadotropin-Releasing Hormone Agonist for the Prevention of Chemotherapy-Induced Ovarian Failure in Patients With Lymphoma: 1-Year Follow-Up of a Prospective Randomized Trial
Authors: Demeestere Isabelle , Brice Pauline , Peccatori Fedro A. , Kentos Alain , Gaillard Isabelle , Zachee Pierre , Casasnovas Rene-Olivier , Van Den Neste Eric , Dechene Julie , De Maertelaer Vivianne , Bron Dominique , Englert Yvon 
Published: November 2012

PurposeTo assess the efficacy of gonadotropin-releasing hormone agonist (GnRHa) in preventing chemotherapy-induced ovarian failure in patients treated for Hodgkin or non-Hodgkin lymphoma within the setting of a multicenter, randomized, prospective trial.Patients and MethodsPatients age 18 to 45 years were randomly assigned to receive either the GnRHa triptorelin plus norethisterone (GnRHa group) or norethisterone alone (control group) concomitantly with alkylating agents containing chemotherapy. The primary end point was the premature ovarian failure (POF) rate (follicle-stimulating hormone [FSH] ≥ 40 IU/L) after 1 year of follow-up.ResultsEighty-four of 129 randomly assigned patients completed the 1-year follow-up. The mean FSH values were higher in the control group than in the GnRHa group during chemotherapy; however, this difference was no longer observed after 6 months of follow-up. After 1 year, 20% and 19% of patients in the GnRHa and control groups, respectively, exhibited POF (P = 1.00). More than half of patients in each group completely restored their ovarian function (FSH < 10 IU/L), but the anti–Müllerian hormone values were higher in the GnRHa group than in the control group (1.4 ± 0.35 v 0.5 ± 0.15 ng/mL, respectively; P = .040). The occurrence of adverse events was similar in both groups with the exception of metrorrhagia, which was more frequently observed in the control group than the GnRHa group (38.4% v 15.6%, respectively; P = .024).ConclusionApproximately 20% of patients in both groups exhibited POF after 1 year of follow-up. Triptorelin was not associated with a significant decreased risk of POF in young patients treated for lymphoma but may provide protection of the ovarian reserve.
Interference of ethylene glycol with L-lactate measurement is assay-dependent
Authors: Tintu Andrei , Rouwet Ellen , Russcher Henk 
Published: November 2012

Background Metabolites of ethylene glycol (EG) can cross-react in L-lactate assays, leading to falsely elevated serum lactate levels in case of EG intoxication. In this study, we evaluated the effects of EG and its metabolites on routinely used lactate measuring methods. Methods Serum aliquots were spiked with either L-lactate, EG or one of its metabolites (all 12.5 mmol/L): glyoxal, glycolate, glyoxylic acid or oxalate. An unspiked sample (L-lactate 2.6 mmol/L) served as a control. L-Lactate levels in these samples were measured in 31 national hospitals on 20 different analysers from nine manufacturers. Results The L-lactate concentrations in the control sample and in the samples spiked with L-lactate, EG, glyoxal and oxalate provided correct results by all routinely used methods. However, the glycolate and glyoxylic acid spiked samples resulted in falsely elevated L-lactate concentration with all blood gas methods and with the majority of general chemistry methods using L-lactate oxidase. Conclusion The EG metabolites glycolate and glyoxylic acid were shown to falsely elevate L-lactate results with most of the currently used methods due to cross-reactivity with the oxidase enzyme. Falsely elevated L-lactate results can lead to misdiagnosis and inappropriate management of patients with EG intoxication.
Analyzing Screening Policies for Childhood Obesity
Authors: Yang Yan , Goldhaber-Fiebert Jeremy D. , Wein Lawrence M. 
Published: November 2012

Because of the health and economic costs of childhood obesity, coupled with studies suggesting the benefits of comprehensive (dietary, physical activity, and behavioral counseling) intervention, the U.S. Preventive Services Task Force recently recommended childhood screening and intervention for obesity beginning at age 6. Using a longitudinal data set consisting of the body mass index of 3,164 children up to age 18 and another longitudinal data set containing the body mass index at ages 18 and 40 and the presence or absence of disease (hypertension and diabetes) at age 40 for 747 people, we formulate and numerically solve—separately for boys and girls—a dynamic programming problem for the optimal biennial (i.e., at ages 2,4,…,16) obesity screening thresholds. Unlike most screening problem formulations, we take a societal viewpoint, where the state of the system at each age is the population-wide probability density function of the body mass index. Compared to the biennial version of the task force's recommendation, the screening thresholds derived from the dynamic program achieve a relative reduction in disease prevalence of 3% at the same screening (and treatment) cost, or—because of the flatness of the disease versus screening trade-off curve—achieves the same disease prevalence at a 28% relative reduction in cost. Compared to the task force's policy, which uses the 95th percentile of body mass index (from cross-sectional growth charts tabulated by the Centers for Disease Control and Prevention) as the screening threshold for each age, the dynamic programming policy treats mostly 16-year-olds (including many who are not obese) and very few males under 14 years old. Although our results suggest that adult hypertension and diabetes are minimized by focusing childhood obesity screening and treatment on older adolescents, the shortcomings in the available data and the narrowness of the medical outcomes considered prevent us from making a recommendation about childhood obesity screening policies.This paper was accepted by Assaf Zeevi, stochastic models and simulation.
Multistage Capital Budgeting for Shared Investments
Authors: Johnson Nicole Bastian , Pfeiffer Thomas , Schneider Georg 
Published: November 2012

This paper studies the performance of delegated decision-making schemes in a two-stage, multidivision capital budgeting problem for a shared investment with an inherent abandonment option. Applying both robust goal congruence and sequential adverse selection frameworks, we show that the optimal capital budgeting mechanism entails a capital charge rate above the firm's cost of capital in the first stage but below the cost of capital in the second stage. Further, the first-stage asset cost-sharing rule depends only on the relative divisional growth profiles, and equal cost sharing can be optimal even when the divisions receive significantly different benefits from the shared investment project. In the presence of an adverse selection problem, all agency costs are incorporated into the second-stage budgeting mechanism, leaving the first-stage capital charge rate and asset-sharing rule unaffected even though the agency problem induces capital rationing at both stages. This paper was accepted by Mary Barth, accounting.
The Effect of Payment Schemes on Inventory Decisions: The Role of Mental Accounting
Authors: Chen Li , Kök A. Gürhan , Tong Jordan D. 
Published: November 2012

Does the payment scheme have an effect on inventory decisions in the newsvendor problem? Keeping the net profit structure constant, we examine three payment schemes that can be interpreted as the newsvendor's order being financed by the newsvendor herself (scheme O), by the supplier through delayed order payment (scheme S), and by the customer through advanced revenue (scheme C). In a laboratory study, we find that inventory quantities exhibit a consistent decreasing pattern in the order of schemes O, S, and C, with the order quantities of scheme S being close to the expected-profit-maximizing solution. These observations are inconsistent with the expected-profit-maximizing model, contradict what a regular or hyperbolic time-discounting model would predict, and cannot be explained by the loss aversion model. Instead, they are consistent with a model that underweights the order-time payments, which can be explained by the “prospective accounting” theory in the mental accounting literature. A second study shows that the results hold even if all physical payments are conducted at the same time, suggesting that the framing of the payment scheme is sufficient to induce the prospective accounting behavior. We further validate the robustness of our model under different profit conditions. Our findings contribute to the understanding of the psychological processes involved in newsvendor decisions and have implications for supply chain financing and contract design. This paper was accepted by Christian Terwiesch, operations management.
Plantar fasciitis
Authors: Cutts S , Obi N , Pasapula C , Chan W 
Published: November 2012

INTRODUCTION In this article we look at the aetiology of plantar fasciitis, the other common differentials for heel pain and the evidence available to support each of the major management options. We also review the literature and discuss the condition. METHODS A literature search was performed using PubMed and MEDLINE®. The following keywords were used, singly or in combination: ‘plantar fasciitis’, ‘plantar heel pain’, ‘heel spur’. To maximise the search, backward chaining of reference lists from retrieved papers was also undertaken. FINDINGS Plantar fasciitis is a common and often disabling condition. Because the natural history of plantar fasciitis is not understood, it is difficult to distinguish between those patients who recover spontaneously and those who respond to formal treatment. Surgical release of the plantar fascia is effective in the small proportion of patients who do not respond to conservative measures. New techniques such as endoscopic plantar release and extracorporeal shockwave therapy may have a role but the limited availability of equipment and skills means that most patients will continue to be treated by more traditional techniques.
Delayed presentation of vernix caseosa peritonitis
Authors: Chambers AC , Patil AV , Alves R , Hopkins JC , Armstrong J , Lawrence RN 
Published: November 2012

INTRODUCTION Vernix caseosa peritonitis (VCP) is a rare and poorly recognised condition resulting from a sustained foreign body reaction to the vernix caseosa of the baby. This case-based review aims to highlight its importance for any medical team managing patients with peritonitis who have undergone a recent Caesarean section. CASE REPORT A 31-year-old woman presented 5 weeks after a Caesarean section with symptoms and signs of peritonitis. CONCLUSIONS Laparotomy and peritoneal lavage is the mainstay of treatment for VCP. Knowledge of the condition may stop inadvertent resection of normal intra-abdominal organs. Greater awareness of VCP is required to ensure earlier recognition as patients can recover well following timely operative intervention.
Patterns of hospital admission with epistaxis for 26,725 patients over an 18-year period in Wales, UK
Authors: Fishpool SJC , Tomkinson A 
Published: November 2012

INTRODUCTION Epistaxis is the one of the most common otorhinolaryngology emergencies. This study examined the age and sex distribution of all patients admitted with epistaxis to National Health Service (NHS) hospitals in Wales, UK, over a period of 18 years and 9 months. METHODS The Patient Episode Database for Wales was examined for all patient admissions with a diagnosis of epistaxis between April 1991 and December 2009. The age and sex of these patients was recorded and the proportion of the underlying population affected was calculated by comparing admission rates to the population data derived from the 1991 and 2001 national population censuses for Wales. RESULTS A total of 26,725 patients were admitted to NHS hospitals in Wales with epistaxis over the period studied. The proportion of the population admitted with epistaxis increased from the age of 40 onwards. For all ages except patients in the 10–14 years group, a higher proportion of the male population was admitted with epistaxis than the comparable female population. This discrepancy was most pronounced between the ages of 15 and 49 years, with the female-to-male ratio of hospital admissions with epistaxis being 0.55. These ages (15 and 49 years) approximate the average age of menarche and menopause respectively in the UK. CONCLUSIONS Women of menstrual age have fewer hospital admissions with epistaxis. This may be due to oestrogens providing protection to the nasal vasculature (as they do to other areas of the vascular tree).