bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnóstico Rápido Participativo e Matriz Swot: Estratégias de Planejamento Estratégico com Base na Atual Posição do Curso de Secretariado Executivo UEPA
Authors: Almeida Aylana Cristina Lima de , Cardoso Alexandre Jorge Gaia 
Published: June 2015

Esta pesquisa tem por objetivo elaborar estratégias de planejamento a partir do Diagnóstico Rápido Participativo (DRP) e da matriz SWOT para o curso de Secretariado Executivo da UEPa, com base em sua posição estratégica, através da análise das forças, fraquezas, oportunidades e ameaças ambientais as quais os curso está sujeito em seu ambiente interno e externo, respectivamente. A pesquisa realizada é de caráter exploratório-descritivo, com abordagem de caráter qualitativo. Foram realizadas oficinas de DRP com os discentes dos quatro anos do curso de secretariado executivo da UEPa com o propósito de identificar, a partir da percepção dos mesmos, as variáveis ambientais que influenciam em sua formação e na gestão do curso pela universidade, considerando aspectos internos e externos. Os resultados da pesquisa apontam para uma postura estratégica de desenkvolvimento do curso, fato que demonstra grandes possibilidades de sucesso em planos que envolvam expansão e a diversificação do curso nos próximos anos. Para tanto, elaborou-se cinco proposições estratégicas coerentes a esta posição estratégica envolvendo os principais aspectos apontados pelos discentes. Verifica-se que o curso de secretariado apresenta aspectos ambientais favoráveis ao alcance dos seus objetivos fundamentais no que envolve a formação, o desenvolvimento acadêmico-profissional e humanístico dos seus discentes.DOI: 10.7769/gesec.v5i2.283
Gestão por Competências com Uso da Metodologia Multicritério na Avaliação de Profissionais de Apoio Administrativo de um Call Center
Authors: Moura Maria do Céu de Sena , Sobral Marcos Felipe Falcão 
Published: June 2015

A tecnologia da informação fez algumas profissões sofrer transformações estruturais, novos cenários impulsionaram os secretários executivos a passar por constantes atualizações e ocasionou a inserção dos profissionais de Secretariado em diferentes contextos empresariais. O presente estudo foi realizado por um profissional de Secretariado Executivo e teve por objetivo realizar a classificação e análise das competências Conhecimento, Habilidade e Atitude (CHA). A avaliação por competências tem sido um instrumento bem sucedido na avaliação do capital humano nas organizações. A classificação à luz da gestão por competências, foi realizada através do Apoio multicritério à decisão utilizando o método francês ELECTRE TRI. Na modelagem os eixos do CHA foram inseridos no algoritmo como critérios e os profissionais avaliados foram tratados como alternativas. A pesquisa de campo de caráter exploratório foi direcionada a 10 profissionais assessores administrativos que atuam num Call Center de Pernambuco. O embasamento teórico permitiu explorar a gestão por competências, Competências do profissional de Secretariado, a evolução do Call Center, Apoio multicriterio à decisão e o ELECTRE TRI. A escolha do Call Center para a realização do estudo ocorreu por possuir em sua estrutura áreas de apoio no qual os profissionais atuam realizando atividades correlatas com a atividade de secretariado. Os resultados mostraram que é possível realizar modelagens para cada tipo de função numa organização. Foi constatado que 50% dos profissionais entrevistados foram classificados com baixo desempenho nas competências e 50% foi classificado com competência elevada, resultado que se justifica quando estratificamos o tempo de atividade dos profissionais.DOI: 10.7769/gesec.v5i3.308
Dominant role of eddies and filaments in the offshore transport of carbon and nutrients in the California Current System
Authors: Nagai Takeyoshi , Gruber Nicolas , Frenzel Hartmut , Lachkar Zouhair , McWilliams James C. , Plattner Gian‐Kasper 
Published: June 2015

AbstractThe coastal upwelling region of the California Current System (CalCS) is a well‐known site of high productivity and lateral export of nutrients and organic matter, yet neither the magnitude nor the governing processes of this offshore transport are well quantified. Here we address this gap using a high‐resolution (5 km) coupled physical‐biogeochemical numerical simulation (ROMS). The results reveal (i) that the offshore transport is a very substantial component of any material budget in this region, (ii) that it reaches more than 800 km into the offshore domain, and (iii) that this transport is largely controlled by mesoscale processes, involving filaments and westward propagating eddies. The process starts in the nearshore areas, where nutrient and organic matter‐rich upwelled waters pushed offshore by Ekman transport are subducted at the sharp lateral density gradients of upwelling fronts and filaments located at ∼25–100 km from the coast. The filaments are very effective in transporting the subducted material further offshore until they form eddies at their tips at about 100–200 km from the shore. The cyclonic eddies tend to trap the cold, nutrient, and organic matter‐rich waters of the filaments, whereas the anticyclones formed nearby encapsulate the low nutrient and low organic matter waters around the filament. After their detachment, both types of eddies propagate further in offshore direction, with a speed similar to that of the first baroclinic mode Rossby waves, providing the key mechanism for long‐range transport of nitrate and organic matter from the coast deep into the offshore environment.
The Multiple Reactions in the Monochlorodimedone Assay: Discovery of Unique Dehalolactonizations under Mild Conditions
Authors: China Hideyasu , Okada Yutaka , Dohi Toshifumi 
Published: June 2015

AbstractThe monochlorodimedone assay has been widely used as an assay of the brominating activity of halogenating enzymes; however, the assumed product was found to spontaneously decompose during the measurement. The decomposition mechanism and systematic error in the assay were explained by five reactions in their multiple reactions. We discovered unique dehalolactonizations of halogenated δ‐keto acids in aqueous solution among many reactions in the assay. Its reaction mechanism was suggested as the cyclization via a cyclopropanone intermediate produced by the intramolecular catalysis of the carboxylate anion.
Immobilization of catalase onto hydrophilic mesoporous poly(ethylene‐co‐vinyl alcohol) monoliths
Authors: Wang Guowei , Xin Yuanrong , Han Wenjuan , Uyama Hiroshi 
Published: June 2015

ABSTRACTPoly(ethylene‐co‐vinyl alcohol) monoliths have been fabricated by a thermally induced phase separation method. Catalase was immobilized onto the monolith surfaces after activating the hydroxyl groups of the monolith in the presence of carbonyldiimidazole. The immobilized catalase exhibited the same optimum pH and temperature values to those of the free catalase. In addition, the immobilized catalase showed better thermal stability and high reusability. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42556.
Facile preparation of asymmetric Ni/PVC film with controlled structure: Application as a high‐performance EMI shielding material
Authors: Zhang Yang , Fang Xiaoxia , Wen Bianying , Zou Wenqi 
Published: June 2015

ABSTRACTControlling the spatial configuration of conductive fillers in thin composites by a facile strategy is critical to widely commercial use these materials for electromagnetic interference (EMI) shielding applications. In this work, a series of free‐standing thin Ni/polyvinyl chloride (PVC) films with the same composition just systematically varied Ni particles dispersion states was prepared by solution casting method. The relationships between the structure and properties were also investigated. Ni particles motion was governed by evaporation and sedimentation during solvent evaporation with the presence of soluble PVC influencing the casting solution viscosity. The experimental results fit the 1D model. In dilute casting system, the effective concentration of Ni particles in the lower part of the film was significantly enhanced and a dense, closed packed conductive network was formed. This special distribution of Ni particles was found to play a key role in the corresponding properties. Compared to the uniform film, the film which was fabricated from the casting solution containing 0.03 g/mL PVC, exhibited much better electrical conductivity and EMI shielding performance. Furthermore, the detailed study shows that the obtained thin film exhibited excellent EMI SE values per unit film thickness of 200 dB/mm. Meanwhile, the resultant films possessed thermal conductivity of 0.32∼0.59 W/(m·K) depended on whether a Ni continuous network formation throughout the whole film in the temperature range of 30∼60°C. Our study results pave thus the way for scalable fabrication of substrate‐free systems that have advantages in multifunctional complex devices. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42560.
Copolymerization and terpolymerization of glycolide with lactones by dimethyl(salicylaldiminato)aluminum compounds
Authors: Fuoco Tiziana , Meduri Angelo , Lamberti Marina , Pellecchia Claudio , Pappalardo Daniela 
Published: June 2015

ABSTRACTThe aliphatic poly(esters) are the most common biodegradable and biocompatible synthetic materials used by far for diverse biomedical applications. Co‐polymers and ter‐polymers of glycolide with ε‐caprolactone and lactide are produced in the presence of dimethyl aluminum compounds, bearing salicylaldiminato bidentate ligands differing for the steric hindrance on the ortho position of the phenolato ring. The formation of random poly[glycolide‐co‐(ε‐caprolactone)] samples is favored with more encumbered catalyst. Transesterification reactions of the second mode also contribute to randomize the structure. Copolymers from semi‐crystalline to amorphous are produced by decreasing the glycolide/ε‐caprolactone feed ratio. The terpolymerization of glycolide with ε‐caprolactone and rac‐lactide with the same catalysts affords amorphous and random poly[(glycolide‐co‐lactide‐co‐(ε‐caprolactone)] samples. The incorporation of the monomers is in this case determined by the bulkiness of the catalysts and by the higher coordination ability of the cyclic diesters. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42567.
Orthogonal design preparation of phenolic fiber by melt electrospinning
Authors: Xie Gai , Chen Zhiyuan , Ramakrishna Seeram , Liu Yong 
Published: June 2015

ABSTRACTThrough orthogonal experimental methods, the melt electrospinning of pure phenolic fibers has been achieved. The preparation is based on an orthogonal experimental method, which was designed to investigate the optimal conditions for production through integrated effects of spinning temperature, gap between spinneret and collector, as well as applied voltage. We found that optimal spinning conditions at 160°C, a spinneret‐to‐collector gap of 8 cm, and applied voltage at 40 kV produce an average electrospun fiber diameter reaching 4.44 ± 0.76 μm, with narrow variance distribution. The fibers were cured in a solution with 18.5% formaldehyde and 12% hydrochloric acid, heated from room temperature to 80°C and maintained 1h. In this report, the morphology, structural changes, and heat resistance of the fibers are characterized. Obtained results reveal that curing the fiber reduces crystallization and improves heat resistance. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2015,132, 42574.
Influence of electrochemical copolymerization conditions of 3‐methylthiophene and biphenyl on the morphology and nanomechanical properties of the films
Authors: Triantou Despina , Soulis Spyridon , Perivoliotis Dimitris , Charitidis Costas 
Published: June 2015

ABSTRACTThe aim of this work is to synthesize novel 3‐methylthiophene (3MTh)/biphenyl (Biph) copolymer films by electropolymerization and study their mechanical properties through nanoindentation. The morphology, the chemical structure as well as the electrical conductivity of the copolymer films depended strongly on the electropolymerization conditions. It was found that the polymer deposition follow an instantaneous, two‐dimensional nucleation and growth mechanism leading to homogenous films. The copolymer films had higher Young modulus and nanohardness than poly(3‐methylthiophene) (3PMTh), indicating that the incorporation of Biph units within the P3MTh chain leads to a more densely packed structure and a more brittle polymer. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42575.
Synthesis of a PPV‐fluorene derivative: Applications in luminescent devices
Authors: Rodrigues Paula C. , Fontes Bruno D. , Torres Bruno B. M. , Sousa Washington S. , Faria Gregório C. , Balogh Debora T. , Faria Roberto M. , Akcelrud Leni 
Published: June 2015

ABSTRACTSynthesis of a polyfluorene/poly(p‐phenylene vinylene) derivative, the Poly [(9,9′‐di‐hexylfluorenediylvinylene‐alt‐1,4‐phenylenevinylene)‐co‐((9,9′‐(3‐t‐butylpropanoate) fluorene‐1,4‐phenylene)] (LaPPS 42) was performed following Wittig and Suzuki routes. Polyfluorenes and derivatives have been used in electroluminescent devices, and the synthesis described here has the advantage in pave the way to get distinct structures having different emission spectra. An extensive study of its electrochemical, thermomechanical, optical, and structural properties was carried out, as well as its application in electroluminescent devices. Polymer light‐emitting diodes (PLEDs) and polymer light‐emitting electrochemical cells (PLECs) were built using LaPPS 42 as active layer, and their electric and optical characterizations confirm they have a potential as active element in electroluminescent devices. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42579.
pH‐sensitive polyelectrolyte films derived from submicron chitosan/Eudragit® L 100‐55 complexes: Physicochemical characterization and in vitro drug release
Authors: Čalija Bojan , Savić Snežana , Krajišnik Danina , Daniels Rolf , Vučen Sonja , Marković Bojan , Milić Jela 
Published: June 2015

ABSTRACTThe objectives of this study were to prepare films from submicron chitosan/Eudragit® L100‐55 polyelectrolyte complexes (CH/EL PEC) and to assess the influence of CH molecular weight and CH/EL mass ratio on their structure and drug‐release properties. The films were obtained by a simple, environmentally friendly, casting/solvent evaporation method and the verapamil hydrochloride (VH) was used as model drug. Submicron size, narrow size distribution, and acceptable stability of CH/EL PECs were confirmed by DLS and laser Doppler microelectrophoresis. SEM analysis revealed nonporous inner structure and flat surface of the films. Interactions between comprising polymers and formation of CH/EL PEC were established by DSC and FT‐IR spectroscopy. In vitro swelling and drug release studies revealed the pH sensitivity of the films, with burst drug release in acidic conditions (pH 1.2) and sustained release in phosphate buffers pH 5.8, 6.8, and 7.4. The slowest VH release was achieved from the films prepared from equal amounts of EL and CH of higher molecular weight, confirming the significance of the CH/EL ratio and CH molecular weight on their ability to sustain drug release. The obtained results suggested that presented, simple, and eco‐friendly preparation procedure can be used to obtain pH‐sensitive CH/EL PEC films with a promising potential as drug carriers. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42583.
Biorenewable polymer composites from tall oil‐based polyamide and lignin‐cellulose fiber
Authors: Liu Kunwei , Madbouly Samy A. , Schrader James A. , Kessler Michael R. , Grewell David , Graves William R. 
Published: June 2015

ABSTRACTTall oil‐based polyamide (PA) was blended with lignin‐cellulose fiber (LCF), an inexpensive, highly abundant byproduct of the pulp and paper industries, to produce environmental‐friendly thermoplastic biocomposites. The effects of the concentration of LCF on the thermal, rheological, and mechanical properties of the composites were studied using differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), thermogravimetric analysis (TGA), rheological testing, and mechanical testing. The morphologies of the composites were investigated using scanning electron microscopy (SEM). The incorporation of LCF did not change the glass relaxation process of the polyamide significantly. Results from rheological testing showed that the complex viscosity and shear storage modulus were increased by LCF. Both the modulus and strength increased with increasing LCF content; however, LCF substantially reduced the tensile elongation of the composites. The thermal stability of the composites was strongly influenced by the concentration of LCF. The onset of the degradation process shifted to lower temperatures with increasing LCF content. We conclude that LCF has strong potential for use as filler that is compatible with tall oil‐based polyamide. Adding LCF to form PA‐LCF composites can lower material costs, reduce material weight, and increase strength and rigidity compared to neat PA. Composites of PA‐LCF could serve as sustainable replacements for petroleum plastics in many industrial applications and would provide additional opportunities to utilize LCF, a highly abundant biorenewable material. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42592.
Clinical Utility of Random Anti–Tumor Necrosis Factor Drug–Level Testing and Measurement of Antidrug Antibodies on the Long‐Term Treatment Response in Rheumatoid Arthritis
Authors: Jani Meghna , Chinoy Hector , Warren Richard B. , Griffiths Christopher E. M. , Plant Darren , Fu Bo , Morgan Ann W. , Wilson Anthony G. , Isaacs John D. , Hyrich KimmeL. , Barton Anne ,   on behalf of the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate Collaborators
Published: June 2015

ObjectiveTo investigate whether antidrug antibodies and/or drug non‐trough levels predict the long‐term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels to optimize future treatment decisions.MethodsA total of 331 patients from an observational prospective cohort were selected (160 patients treated with adalimumab and 171 treated with etanercept). Antidrug antibody levels were measured by radioimmunoassay, and drug levels were measured by enzyme‐linked immunosorbent assay in 835 serial serum samples obtained 3, 6, and 12 months after initiation of therapy. The association between antidrug antibodies and drug non‐trough levels and the treatment response (change in the Disease Activity Score in 28 joints) was evaluated.ResultsAmong patients who completed 12 months of followup, antidrug antibodies were detected in 24.8% of those receiving adalimumab (31 of 125) and in none of those receiving etanercept. At 3 months, antidrug antibody formation and low adalimumab levels were significant predictors of no response according to the European League Against Rheumatism (EULAR) criteria at 12 months (area under the receiver operating characteristic curve 0.71 [95% confidence interval (95% CI) 0.57, 0.85]). Antidrug antibody–positive patients received lower median dosages of methotrexate compared with antidrug antibody–negative patients (15 mg/week versus 20 mg/week; P = 0.01) and had a longer disease duration (14.0 versus 7.7 years; P = 0.03). The adalimumab level was the best predictor of change in the DAS28 at 12 months, after adjustment for confounders (regression coefficient 0.060 [95% CI 0.015, 0.10], P = 0.009). Etanercept levels were associated with the EULAR response at 12 months (regression coefficient 0.088 [95% CI 0.019, 0.16], P = 0.012); however, this difference was not significant after adjustment. A body mass index of ≥30 kg/m2 and poor adherence were associated with lower drug levels.ConclusionPharmacologic testing in anti–tumor necrosis factor–treated patients is clinically useful even in the absence of trough levels. At 3 months, antidrug antibodies and low adalimumab levels are significant predictors of no response according to the EULAR criteria at 12 months.
Prediction of Sjögren's Syndrome Years Before Diagnosis and Identification of Patients With Early Onset and Severe Disease Course by Autoantibody Profiling
Authors: Theander Elke , Jonsson Roland , Sjöström Bitte , Brokstad Karl , Olsson Peter , Henriksson Gunnel 
Published: June 2015

ObjectiveAutoantibodies are highly characteristic of primary Sjögren's syndrome (SS) and represent important tools for studying its pathogenesis. Nonetheless, thus far, no systematic investigations have assessed the presence of autoantibodies before diagnosis. This study was undertaken to analyze how early and in what order autoantibodies appear, how predictive they are of primary SS, and whether they identify disease subsets.MethodsA nested case–control design linking data from the Malmö primary SS registry and 3 Swedish healthcare biobanks was applied. In all, 175 serum samples obtained from 117 individuals before diagnosis of primary SS and 1 serum sample from each of 117 matched controls were analyzed for antinuclear antibodies (ANAs), rheumatoid factor (RF), and antibodies against Ro 60/SSA, Ro 52/SSA, and La/SSB.ResultsConsidering all patients with primary SS who were autoantibody positive after diagnosis, at least one autoantibody specificity was detected in 81% up to 20 years (median 4.3–5.1 years) before diagnosis. Those found most often were ANAs, followed by RF, anti–Ro 60/SSA, anti–Ro 52/SSA, and anti‐La/SSB. Anti‐Ro/SSA and anti‐La/SSB antibodies were strongly associated with the risk of developing primary SS, especially early‐onset disease and a severe disease course. When Bayesian prior prevalence estimates for primary SS were included in the calculation, prediagnostic anti–Ro 60/SSA and anti–Ro 52/SSA had the highest positive predictive values (25% and 100%, respectively).ConclusionOur findings indicate that autoantibodies are present for up to 18–20 years before the diagnosis of primary SS, but we cannot exclude even earlier seropositivity, since for most patients, the earliest sample analyzed was positive. In families with multiple cases of autoimmune disease, autoantibody profiling, along with assessment of genetic risk, enables identification of susceptible individuals in a predisease state.
Sensitive determination of enoxacin in pharmaceutical formulations by its quench effect on the fluorescence of glutathione‐capped CdTe quantum dots
Authors: Yang Qiong , Tan Xuanping , Yang Jidong 
Published: June 2015

AbstractA sensitive and simple method for the determination of enoxacin (ENX) was developed based on the fluorescence quenching effect of ENX for glutathione (GSH)‐capped CdTe quantum dots (QDs). Under optimum conditions, a good linear relationship was obtained from 4.333 × 10−9 mol⋅L−1 to 1.4 × 10−5 mol⋅L−1 with a correlation coefficient (R) of 0.9987, and the detection limit (3σ/K) was 1.313 × 10−9 mol⋅L−1. The corresponding mechanism has been proposed on the basis of electron transfer supported by ultraviolet–visible (UV) light absorption, fluorescence spectroscopy, and the measurement of fluorescence lifetime. The method has been applied to the determination of ENX in pharmaceutical formulations (enoxacin gluconate injections and commercial tablets) with satisfactory results. The proposed method manifested several advantages such as high sensitivity, short analysis time, low cost and ease of operation. Copyright © 2015 John Wiley & Sons, Ltd.