bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A One‐Pot Approach to 4,5‐Dihydropyrazoles from Ketones, Arylacetylenes, and Hydrazines.
Authors: Wang Ying‐Chun , Wang Heng‐Shan , Huang Guo‐Bao , Huang Fu‐Ping , Hu Kun , Pan Ying‐Ming 
Published: July 2014

AbstractA general strategy for the three‐component condensation of ketones, hydrazines, and terminal arylalkynes, to give polysubstituted 4,5‐dihydropyrazoles, generally in good yields, is presented.
ChemInform Abstract: Asymmetric Domino Aza‐Michael Addition/[3 + 2] Cycloaddition Reactions as a Versatile Approach to α,β,γ‐Triamino Acid Derivatives.
Authors: Kapras Vojtech , Pohl Radek , Cisarova Ivana , Jahn Ullrich 
Published: July 2014

AbstractNonaflyl azide serves as an effective diazo transfer reagent forming a link between the conjugate addition and cycloaddition steps.
ChemInform Abstract: Synthesis of Benzimidazoles by Copper‐Catalyzed Aerobic Oxidative Domino Reaction of 1,2‐Diaminoarenes and Arylmethyl Halides.
Authors: Qiu Dezhi , Wei Haidong , Zhou Lihong , Zeng Qingle 
Published: July 2014

AbstractThe title compounds are synthesized by a simple, practical, and cost‐saving method tolerating wide range of functional groups.
ChemInform Abstract: Facile Synthesis of 3,5‐Diaryl‐1,2,4‐triazoles via Copper‐Catalyzed Domino Nucleophilic Substitution/Oxidative Cyclization Using Amidines or Imidates as Substrates.
Authors: Sudleendran Kavitha , Schmidt Dietmar , Frey Wolfgang , Conrad Juergen , Beifuss Uwe 
Published: July 2014

AbstractOxidative Cu‐catalyzed dimerization of arylamidines (I) offers a convenient synthesis of 3,5‐diaryl‐1,2,4‐triazoles (II).
ChemInform Abstract: Direct (Het)Arylation of Fluorinated Benzothiadiazoles and Benzotriazole with (Het)Aryl Iodides.
Authors: He Chun‐Yang , Wu Cai‐Zhi , Qing Feng‐Ling , Zhang Xingang 
Published: July 2014

AbstractA simple and efficient method to prepare a wide range of symmetrical and unsymmetrical fluorinated benzothiadiazole—arene molecules as well as benzotriazole analogues is reported.
ChemInform Abstract: Divergent Syntheses of Fused β‐Naphthol and Indene Scaffolds by Rhodium‐Catalyzed Direct and Decarbonylative Alkyne—Benzocyclobutenone Couplings.
Authors: Chen Peng‐hao , Xu Tao , Dong Guangbin 
Published: July 2014

AbstractRhodium catalyzed isomerization of benzocyclobutenones having an propargyloxy substituent offers an unique approach to fused β‐naphthol.
ChemInform Abstract: Pd‐N‐Heterocyclic Carbene Catalyzed Synthesis of Piperidine Alkene—Alkaloids and Their Anticancer Evaluation.
Authors: Kankala Shravankumar , Kankala Ranjith Kumar , Balaboina Ramesh , Thirukovela Narasimha Swamy , Vadde Ravinder , Vasam Chandra Sekhar 
Published: July 2014

AbstractOptimum reaction conditions are examined for the Heck reaction of (I) with various aromatic alkenes which is the key step to synthesize the 10 title compounds of type (IV).
ChemInform Abstract: Efficient Approach to Allylated Quinolines via Palladium‐Catalyzed Cyclization—Allylation of 1‐Azido‐2‐(2‐propynyl)benzenes with Allyl Methyl Carbonate.
Authors: Luo Jiang , Huo Zhibao , Fu Jun , Jin Fangming , Yamamoto Yoshinori 
Published: July 2014

AbstractOf tested allyl donors only allyl methyl carbonate (II) shows superior reactivity.
ChemInform Abstract: Alkyltriflate‐Triggered Annulation of Arylisothiocyanates and Alkynes Leading to Multiply Substituted Quinolines Through Domino Electrophilic Activation.
Authors: Zhao Peng , Yan Xiaoyu , Yin Hang , Xi Chanjuan 
Published: July 2014

AbstractThe structures of products (IVb) and (XIIIb) are confirmed by X‐ray analysis.
ChemInform Abstract: A Stable Microporous Mixed‐Metal Metal—Organic Framework with Highly Active Cu2+ Sites for Efficient Cross‐Dehydrogenative Coupling Reactions.
Authors: Yang Xiu‐Li , Zou Chao , He Yabing , Zhao Min , Chen Banglin , Xiang Shengchang , O'Keeffe Michael , Wu Chuan‐De 
Published: July 2014

AbstractThe syntheses of the nanotubular Mn/Cu‐catalyst MOF as well as a Ni/Mn‐analogue containing nanopore cages are described.
ChemInform Abstract: TMP—Magnesium and TMP—Zinc Bases for the Regioselective Metalation of the Cinnoline Scaffold.
Authors: Klatt Thomas , Roman Daniela Sustac , Leon Thierry , Knochel Paul 
Published: July 2014

AbstractRegioselective functionalizations of cinnoline at the 3 or 8 position are achieved using a frustrated Lewis pair (BF3·OEt2/Mg(Tmp)2·2LiCl) or in situ generated Zn(Tmp)2·2MgCl2·2LiCl, respectively.
ChemInform Abstract: An Eco‐Friendly Water Mediated Synthesis of 1,2,3‐Triazolyl‐2‐aminopyrimidine Hybrids as Highly Potent Antibacterial Agents.
Authors: Nagarajan Sangaraiah , Shanmugavelan Poovan , Sathishkumar Murugan , Selvi Ramasamy , Ponnuswamy Alagusundaram , Harikrishnan Hariharan , Shanmugaiah Vellasamy 
Published: July 2014

AbstractAn elegant, environmentally‐friendly synthesis of a library of the title hybrid molecules (III) (12 examples) is developed.
ChemInform Abstract: A Facile Synthesis of the Novel Thiazolo[3,2‐a]pyrimidine Derivatives.
Authors: Studzinska Renata , Wroblewski Marcin , Karczmarska‐Wodzka Aleksandra , Kolodziejska Renata 
Published: July 2014

Abstract3‐Allyl‐2‐thiouracils (I) and (IV) are converted into thiazolopyrimidinones (III) and (VII) respectively.
ChemInform Abstract: Gold(I)‐Catalyzed Reactions of 1‐(ortho‐Alkynylaryl)ureas: Highly Selective Heterocyclization and Synthesis of Mixed N,O‐Acetals.
Authors: Gimeno Ana , Cuenca Ana B. , Medio‐Simon Mercedes , Asensio Gregorio 
Published: July 2014

AbstractTreatment of alkynylureas (I) with trifluoroethanol in the presence of a Au/Ag catalytic system provides N‐6‐exo‐dig heterocyclization products (III) and in some cases open chain acetals as side products.
ChemInform Abstract: Syntheses of Hydroxamic Acid‐Containing Bicyclic β‐Lactams via Palladium‐Catalyzed Oxidative Amidation of Alkenes.
Authors: Jobbins Maria O. , Miller Marvin J. 
Published: July 2014

AbstractThe Pd‐catalyzed ring closure of the unsaturated amides (III) allows stereoselective access to novel bicyclic β‐lactams.
ChemInform Abstract: 6‐Triazolyl‐Substituted Sulfocoumarins Are Potent, Selective Inhibitors of the Tumor‐Associated Carbonic Anhydrases IX and XII.
Authors: Grandane Aiga , Tanc Muhammet , Zalubovskis Raivis , Supuran Claudiu T. 
Published: July 2014

AbstractA variety of 6‐substituted sulfocoumarins incorporating triazolyl moieties are synthesized by employing click chemistry.
ChemInform Abstract: Synthesis of (Z)‐1‐Thio‐ and (Z)‐2‐Thio‐1‐alkenyl Boronates via Copper‐Catalyzed Regiodivergent Hydroboration of Thioacetylenes: An Experimental and Theoretical Study.
Authors: Zhu Gangguo , Kong Wei , Feng Hui , Qian Zhaosheng 
Published: July 2014

AbstractFor the first time a highly selective α‐ and β‐borylation of thioacetylenes is developed by using bis(pinacolato)diboron (II) or pinacolborane (X).
ChemInform Abstract: Manganese(III)‐Mediated Selective Diphenylphosphinoyl Radical Reaction of 1,4‐Diaryl‐1‐butynes for the Synthesis of 2‐Phosphinoylated 3,4‐Dihydronaphathalenes.
Authors: Li Da‐Peng , Pan Xiang‐Qiang , An Li‐Tao , Zou Jian‐Ping , Zhang Wei 
Published: July 2014

AbstractThis reaction can be further extended for analogous substrates for the synthesis of indene, benzoannulene, and other heterocyclic skeletons.
ChemInform Abstract: Sodium Phosphaethynolate as a Building Block for Heterocycles.
Authors: Chen Xiaodan , Alidori Simone , Puschmann Florian Frank , Santiso‐Quinones Gustavo , Benko Zoltan , Li Zhongshu , Becker Gerd , Gruetzmacher Hans‐Friedrich , Gruetzmacher Hansjoerg 
Published: July 2014

AbstractNaOCP is a useful building block to synthesize a variety of phosphorus‐containing five‐ and six‐membered heterocycles in good yields.
ChemInform Abstract: Efficient Synthesis of Nebularine and Vidarabine via Dehydrazination of (Hetero)aromatics Catalyzed by CuSO4 in Water.
Authors: Xia Ran , Xie Ming‐Sheng , Niu Hong‐Ying , Qu Gui‐Rong , Guo Hai‐Ming 
Published: July 2014

AbstractAntiviral drugs nebularine (Ia) and vidarabine (IIa) are readily prepared by a dehydrazination of corresponding precursors (Ib) and (IIb).
ChemInform Abstract: Two New Eupodienone Lignans from Gymnotheca chinensis.
Authors: Xiao Shi‐Ji , Chen Fang , Ding Li‐Sheng , Zhou Yan 
Published: July 2014

Abstractisolation, structure elucidation and cytotoxicity of two new eupodienone lignans, gymnothelignan T (I) and gymnothelignan U (II)
ChemInform Abstract: Fabrication of 3D Porous Mn Doped α‐Fe2O3 Nanostructures for the Removal of Heavy Metals from Wastewater.
Authors: Cui Hao‐Jie , Cai Jie‐Kui , Shi Jian‐Wen , Yuan Baoling , Ai Cui‐Ling , Fu Ming‐Lai 
Published: July 2014

AbstractPorous Mn‐doped α‐Fe2O3 nanostructures are prepared by calcination (500 °C, 3 h) of carbon spheres containing FeII and MnII ions which are obtained by hydrothermal treatment of FeSO4 and MnSO4 (4:1) and glucose (H2O, autoclave, 160 °C, 4 h).
ChemInform Abstract: 1,3,4‐Thiadiazole. Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry
Authors: Hu Yang , Li Cui‐Yun , Wang Xiao‐Ming , Yang Yong‐Hua , Zhu Hai‐Liang 
Published: July 2014

AbstractReview: 569 refs.
ChemInform Abstract: Function of Nanocatalyst in Chemistry of Organic Compounds Revolution: An Overview
Authors: Kanagarajan Hemalatha , Gunabalan Madhumitha , Kajbafvala Amir , Narayanan Anupama , Sompalle Rajesh , Roopan Selvaraj Mohana 
Published: July 2014

AbstractReview: 120 refs.
Augmented Berlin‐Frankfurt‐Münster therapy in adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL)
Authors: Rytting Michael E. , Thomas Deborah A. , O'Brien Susan M. , Ravandi‐Kashani Farhad , Jabbour Elias J. , Franklin Anna R. , Kadia Tapan M. , Pemmaraju Naveen , Daver Naval G. , Ferrajoli Alessandra , Garcia‐Manero Guillermo , Konopleva Marina Y. , Cortes Jorge E. , Borthakur Gautham , Garris Rebecca , Cardenas‐Turanzas Maria , Schroeder Kurt , Jorgensen Jeffrey L. , Kornblau Steven M. , Kantarjian Hagop M. 
Published: July 2014

BACKGROUNDVarious trials have reported improved outcomes for adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) who received treatment with pediatric‐based regimens. Those reports prompted the current investigation of the pediatric augmented Berlin‐Frankfurt‐Münster (ABFM) regimen in AYA patients. The results were compared with those from a similar population that received the hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper‐CVAD) regimen.METHODSEighty‐five patients ages 12 to 40 years who had Philadelphia chromosome (Ph)‐negative ALL received the ABFM regimen from October 2006 through April 2012. Their outcome was compared with outcomes in 71 historic AYA patients who received hyper‐CVAD from the authors' institution. Patient and disease characteristics, as well as minimal residual disease status, were analyzed for their impact on outcomes.RESULTSThe complete response rate with ABFM was 94%. The 3‐year complete remission duration (CRD) and overall survival (OS) rates were 70% and 74%, respectively. For patients aged ≤21 years, the 3‐year CRD and OS rates were 72% and 85%, respectively; and, for patients ages 21 to 40 years, the respective rates were 69% and 60%. The initial white blood cell count was an independent predictive factor of OS and CRD. The minimal residual disease status on days 29 and 84 of therapy also were predictive of long‐term outcomes. Severe regimen toxicities included transient hepatotoxicity in 35% to 39% of patients, pancreatitis in 11% of patients, osteonecrosis in 11% of patients, and thrombosis in 22% of patients. The 3‐year OS rate was 74% in the ABFM group versus 71% in the hyper‐CVAD group, and the corresponding 3‐year CRD rate was 70% versus 66%, respectively.CONCLUSIONSABFM was tolerable in AYA patients with ALL but was not associated with significant improvements in CRD and OS compared with hyper‐CVAD.Cancer2014;120:3660–3668.©2014 American Cancer Society.
Mechanism of Back Electron Transfer in an Intermolecular Photoinduced Electron Transfer Reaction: Solvent as a Charge Mediator
Authors: Narra Sudhakar , Nishimura Yoshifumi , Witek Henryk A. , Shigeto Shinsuke 
Published: July 2014

AbstractBack electron transfer (BET) is one of the important processes that govern the decay of generated ion pairs in intermolecular photoinduced electron transfer reactions. Unfortunately, a detailed mechanism of BET reactions remains largely unknown in spite of their importance for the development of molecular photovoltaic structures. Here, we examine the BET reaction of pyrene (Py) and 1,4‐dicyanobenzene (DCB) in acetonitrile (ACN) by using time‐resolved near‐ and mid‐IR spectroscopy. The Py dimer radical cation (Py2.+) and DCB radical anion (DCB.−) generated after photoexcitation of Py show asynchronous decay kinetics. To account for this observation, we propose a reaction mechanism that involves electron transfer from DCB.− to the solvent and charge recombination between the resulting ACN dimer anion and Py2.+. The unique role of ACN as a charge mediator revealed herein could have implications for strategies that retard charge recombination in dye‐sensitized solar cells.
Metal Coordination and Isomerization of a Hydrazone Switch
Authors: Croteau Molly L. , Su Xin , Wilcox Dean E. , Aprahamian Ivan 
Published: July 2014

AbstractMetal coordination and isomerization of a hydrazone‐based molecular switch (1) was investigated with isothermal titration calorimetry (ITC) and UV/Vis spectroscopy. Three equilibria—initial binding, ligand redistribution, and isomerization (1→1′)—are required to characterize the interaction of metal ions with the molecular switch. The stoichiometry of the initial complex and the relative magnitudes of the three equilibria constants depend on the size and Lewis acidity of the metal ion and competition from the counterion. Strongly coordinating anions (e.g., Cl−) suppress the formation of the initial metal–switch complex and isomerization. The thermodynamics for the equilibrium M2++2 1⇌M(1′)22+ have been determined for Zn2+, Cd2+, and Hg2+ from the ITC data.
The Chemistry of Ni–Sb Carbonyl Clusters – Synthesis and Characterization of the [Ni19Sb4(CO)26]4– Tetraanion and the Viologen Salts of [Ni13Sb2(CO)24]n– Carbonyl Clusters
Authors: Femoni Cristina , Iapalucci Maria Carmela , Longoni Giuliano , Zacchini Stefano , Ciabatti Iacopo , Della Valle Raffaele Guido , Mazzani Marcello , Riccò Mauro 
Published: July 2014

AbstractWithin the reinvestigation of Ni–Sb carbonyl cluster chemistry, we report here the synthesis and characterization of the new [Ni19Sb4(CO)26]4– cluster and the synthesis, structure, magnetic characterization and electrical resistivity of the viologen salts of the previously known [Ni13Sb2(CO)24]n– (n = 2, 3) anionic species. The crystal structures of [NEt4]4[Ni19Sb4(CO)26], [EtV]8[Ni13Sb2(CO)24]3·4DMF·2C6H14 and [EtV]3[Ni13Sb2(CO)24]·1.5THF (EtV = 1,1′‐diethyl‐4,4′‐bipyridilium cation, DMF = N,N‐dimethylformamide, THF = tetrahydrofuran) are described. Notably, the unit cell of [EtV]8[Ni13Sb2(CO)24]3·4DMF·2C6H14 involves a mixture of two [Ni13Sb2(CO)24]3– trianions and one [Ni13Sb2(CO)24]2– dianion, as it also contains eight [EtV]+· radical monocations, which are assembled in infinite stacks. In contrast, the unit cell of the [EtV]3[Ni13Sb2(CO)24]·1.5THF salt contains four [Ni13Sb2(CO)24]3– trianions along with twelve [EtV]+· radical monocations, four of which are arranged into two pairs of isolated dimers, whereas the other two sets of four form two infinite stacks that extend over the whole crystal. The charges of the miscellaneous ions have been assigned on the basis of electroneutrality and spectroscopic evidence. More specifically, the infrared spectra of [EtV]8[Ni13Sb2(CO)24]3·4DMF·2C6H14, both in the solid state and in solution, clearly indicate the presence of a 2:1 mixture of [Ni13Sb2(CO)24]3– and [Ni13Sb2(CO)24]2– anions. Resistivity measurements performed on pellets of powdered samples indicate that the [EtV]8[Ni13Sb2(CO)24]3·4DMF·2C6H14 salt substantially behaves as an insulator. A study of the magnetic behaviour of [EtV]8[Ni13Sb2(CO)24]3·4DMF·2C6H14 evidences pairing among the electrons of the EtV+· molecules, in agreement with DFT calculations, and the odd‐electron clusters behave as paramagnetic centres of spin S = 1.
Aromaticity and Magnetic Properties of 1‐ and 2‐Indenones and Their Aza Derivatives
Authors: Poater Jordi , Solà Miquel , Alkorta Ibon , Elguero José 
Published: July 2014

AbstractThe almost unknown series of 1‐ and 2‐indenones and their aza‐derivatives have been analyzed with the aim of understanding the higher stability and aromaticity of the 1‐one compared to the 2‐one series. The effect of tetrafluorination of the six‐membered ring on their relative stability and aromaticity and the corresponding 19F–19F spin–spin coupling constants (SSCC) have been analyzed for the compounds of these two series. Magnetic NICS and electronic PDI, FLU, and MCI aromaticity criteria, complemented by an energy decomposition analysis, allow the higher stability and aromaticity of 1‐indenones compared with 2‐indenones to be attributed to the π‐component of the orbital interaction term. The reduced aromatic character of the 2‐one series also provides an explanation for the 19F–19F SSCC observed in the tetrafluorinated 2‐one compounds, which differ significantly from those of 1,2,3,4‐tetrafluorobenzene.
Unsymmetrical vic‐Tricarbonyl Compounds for the Total Syntheses of Cladoniamide G and Cladoniamide F
Authors: Schütte Julia , Kilgenstein Frank , Fischer Michel , Koert Ulrich 
Published: July 2014

AbstractA 2‐unsubstituted indole adds under Cu‐box‐catalysis to mesoxalic ester amides with high enantioselectivity, whereas low enantiomeric excess is obtained for 2‐substituted indoles. A mesoxalic ester amide is used as key component in the total syntheses of alkaloids cladoniamide G and cladoniamide F. The natural product syntheses involve Suzuki cross‐coupling to a 2,2′‐biindole, arylation of the vic‐tricarbonyl compound, and intramolecular lactam formation.
Gold Nanobone/Carbon Nanotube Hybrids for the Efficient Nonenzymatic Detection of H2O2 and Glucose
Authors: Jou Amily Fang‐ju , Tai Nyan‐Hwa , Ho Ja‐an Annie 
Published: July 2014

AbstractWe report a facile strategy for the synthesis of gold nanobone/carbon nanotube (CNT@GNB) nanoassemblies, which were prepared through hybridization of CNTs and GNBs mediated by a thiolated pyrene derivative. The SEM images confirmed the successful construction of the CNT@GNB nanoassemblies. Screen printed electrodes modified with the CNT@GNB nanoassemblies exhibited decent electrocatalytic activity, large surface‐to‐volume ratios, high electrochemical reversibility, and efficient electron transport properties, thereby enabling stable and sensitive nonenzymatic detection of H2O2 and glucose, with detection limits of 0.8 µM and 0.07 mM, respectively. Moreover, no interference was observed at a potential of +0.38 V for the interfering species, such as ascorbic acid and urea, indicating high selectivity toward the glucose detection.
Detection of S‐adenosylhomocysteine and methylation index in blood by capillary electrophoresis
Authors: Ivanov Alexander V. , Luzyanin Boris P. , Virus Edward D. , Rotkina Anna S. , Kubatiev Aslan A. 
Published: July 2014

This work proposes an approach to the direct analysis of S‐adenosylhomocysteine (SAH) and the methylation index in blood using CE with UV detection (CE‐UV). After application of meglumine postinjection, we achieved SAH in‐capillary preconcentration in the HClO4 extracts of erythrocytes, which improved the detection limit (S/N = 3) of SAH up to 3 fmol or 180 nmol/L at the injection volume of 50 nL, taking into account the sample dilution rate. CE‐UV was carried out in 30 mM glycine and 45 mmol/L HCl (pH ∼1.8) at 17 kV in a capillary 48 cm in length and 50 μm id. Accuracy of the technique was 101% and reproducibility was about 12%.
A simulation study of a bioethanol‐solar‐reforming system for proton‐exchange membrane fuel cell home cogeneration system
Authors: Obara Shin'ya 
Published: July 2014

AbstractThe energy supply characteristic of a proton‐exchange membrane fuel cell for houses is strongly influenced in a hydrogen supply unit. Therefore, a bioethanol reforming system (FBSR) with a sunlight heat source is developed as a potential fuel supply system for distributed fuel cells. However, the temperature distribution of a catalyst layer in the reactor is not stable under conditions of unstable solar radiation and unstable outside air temperature; as a result, it is thought that the inversion ratio (the percentage of hydrogen obtained from ethanol) of a reforming reaction will decrease. In this paper, heat transmission analysis was used in the catalyst layer of the reformer of FBSR, and the fundamental performance of FBSR was investigated. Fluctuations of the solar insolation over a short period of time affect the hydrogen‐generating rate of FBSR. Moreover, the amount of hydrogen production of FBSR was simulated using meteorological data from a day in March and a day in August in a cold region (Sapporo in Japan). In this research, the relation between the collected area of a solar collector and the energy supply to an individual house was obtained.
Applying multi‐parameter runoff elasticity to assess water availability in a changing climate: an example from Texas, USA
Authors: Brikowski T. H. 
Published: July 2014

AbstractAdaptation and mitigation efforts related to global trends in climate and water scarcity must often be implemented at the local, single‐catchment scale. A key requirement is understanding the impact of local climate and watershed characteristics coupled with these regional trends. For surface water, determination of multi‐parameter runoff elasticities is a promising tool for achieving such understanding, as explored here for two surface‐water dependent basins in Texas. The first basin is the water supply for Dallas‐Ft. Worth (DFW), and exhibits relatively high precipitation elasticity (proportional change in runoff to change in precipitation) εP = 2.64, and temperature elasticity εT = − 0.41. Standard precipitation–temperature elasticity diagrams exhibit unusual concave contours of runoff change, indicating influence of additional parameters, which can be isolated using multi‐parameter approaches. The most influential local parameter in DFW is unexpected reduced runoff fraction in cooler wetter years. Those years exhibit increased summer (JJA) precipitation fraction, but predominant cracking soils in DFW minimize JJA runoff, yielding negative . A comparative basin near Houston shows positive , reflecting the local impact of tropical cyclones and lesser abundance of cracking soils. Both basins exhibit positive elasticity to 1‐year previous precipitation (e.g. DFW εP − 1 = 1.24), reflecting the influence of soil moisture storage. Only DFW exhibits negative elasticity to 2‐year previous precipitation (εP − 2 = − 0.65), reflecting multi‐year influence of vegetation growth and increased evapotranspiration.Using these elasticities, analysis of historical multi‐decadal climate departures for DFW indicates the 80% decrease in runoff during the 1950–1957 drought of record was primarily caused by reduced precipitation. Runoff 56% above‐normal during an unprecedented 1986–1998 wet period was primarily caused by increased precipitation. Since 2000, despite precipitation slightly above normal, runoff has decreased 20%, primarily in response to ∼ 1∘C warming. Future precipitation droughts superimposed on this new drier normal are likely to be much more severe than historical experience would indicate. Copyright © 2014 John Wiley & Sons, Ltd.