bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of FinTox: A new screening tool to assess cancer‐related financial toxicity
Authors: Badr Hoda , Han Jessie , Mims Martha 
Published: August 2024

AbstractPurposeThis study aimed to develop and validate FinTox, a concise tool for screening and managing financial toxicity in oncology settings.MethodsDevelopment involved qualitative interviews with healthcare providers and patients, and feedback from a 7‐member expert panel resulting in a 5‐item measure that evaluates financial strain, psychological responses, and care modifications. Psychometric evaluations examined factor structure, internal consistency, test–retest reliability, and concurrent and convergent validity. Associations between FinTox scores and sociodemographic/medical factors were also analyzed using univariate and multivariable regression models.ResultsTwelve healthcare providers and 20 patients were interviewed, and 268 patients (69.8% female, 47.4% non‐Hispanic White) completed surveys including FinTox, the Comprehensive Score for Financial Toxicity (COST), health‐related quality of life (HRQOL) measures, and sociodemographic questions. FinTox demonstrated excellent internal consistency (Cronbach's alpha = 0.90) and test–retest reliability (ICC = 0.95). Significant correlations with the COST (r = −0.62, p < 0.001) and HRQOL measures corroborated content and convergent validity. Diagnostic accuracy was evidenced by a sensitivity of 72.3%, specificity of 85.2%, positive predictive value of 83.2%, and negative predictive value of 70.3%. Higher FinTox scores were also associated with receiving care at a safety‐net hospital, Black race, household income <600% of the federal poverty level, and Stage 4 cancer.ConclusionFinTox's robust psychometric properties and diagnostic accuracy position it as a reliable tool for detecting financial toxicity. Future research should evaluate its responsiveness to changes over time and integration into clinical workflows.
Elucidating Evolutionary Mechanisms and Variants of the Hammerhead Ribozyme Using In Vitro Selection
Authors: Brill Jake , Nurmi Connor , Li Yingfu 
Published: August 2024

AbstractThe Hammerhead Ribozyme (HHR) is a ubiquitous RNA enzyme that catalyzes site‐specific intramolecular cleavage. While mutations to its catalytic core have traditionally been viewed as detrimental to its activity, several discoveries of naturally occurring variants of the full‐length ribozyme challenge this notion, suggesting a deeper understanding of HHR evolution and functionality. By systematically introducing mutations at key nucleotide positions within the catalytic core, we generated single‐, double‐, and triple‐mutation libraries to explore the sequence requirements and evolution of a full‐length HHR. In vitro selection revealed many novel hammerhead variants, some of which possess mutations at nucleotides previously considered to be essential. We also demonstrate that the evolutionary trajectory of each nucleotide in the catalytic core directly correlates with their functional importance, potentially giving researchers a novel method to assess the sequence requirements of functional nucleic acids.
A retrospective of 50 years of NDCC publication: Advancing perspectives over time
Authors: Smith Everrett A. , D'Amico Mark M. , Garza Mitchell Regina , Eddy Pamela L. 
Published: August 2024

AbstractWhen Arthur Cohen launched New Directions for Community Colleges (NDCC) in 1973, the focus was on sharing updates and practical advice for those leading and working in community colleges. At the time, scant attention was given to these institutions as most research centered on 4‐year colleges and universities. The context of community colleges matters in how finance and governance occur and in how leaders help their institutions navigate a constantly changing external environment that requires flexibility in meeting workforce needs. Fifty years have passed since the initial issue of NDCC was published, and this retrospective draws connections on three topics over time. First, this article reviews how finance and governance evolved, taking note of how the expansion of the sector and the complexity of operations altered operations. Second, a look at career and technical education (CTE) and workforce development occurs. The historical roots of vocational education in community colleges translate to new approaches to developing a skilled workforce to address employer demand. Finally, a review of leadership since the first issue was published shows how ideas of leadership have expanded and help identify new challenges leaders face.
Navigating the skill‐first economy: The evolving role of lifelong learning and career services at community colleges
Authors: Siddiqi Muddassir 
Published: August 2024

AbstractThe rapid pace of technological change is revolutionizing every sector of the economy, transforming how value is created and delivered to consumers through technologies like robotics, virtual reality, artificial intelligence, and the Internet of Things. This transformation underscores the need for a diverse workforce as the new skills valued and essential to employers are changing. In this context, community colleges are thrust into the national debate around the best options for educating skilled employees, given their historical role in preparing a significant portion of the national workforce and employers’ reliance on them as primary providers of middle‐skills training. A vital aspect behind this debate is elevating accountability calls from policymakers, parents, and students who question the value of a college degree and expect a return on investment in employment outcomes. Another aspect of this debate is the growing employers’ concerns about the readiness of graduates, which affects the ability of companies to implement new products, services, or business technologies. For many, there is a gap between the supply and demand of skilled workers and community colleges are not serving the needs of their students, employers, and communities. The article suggests two strategies to address the challenges associated with a skilled‐first economy and employee skills mismatch: (1) developing different approaches to credentialing by embracing lifelong learning, and (2) strengthening the collaboration between career services and employers to effectively support lifelong learning.
Dens evagination and complete invagination in the same tooth with extraoral fistula: A rare case report
Authors: Bolhari Behnam , Ghabraei Sholeh , Noori Faranak , Hashemi Nasim 
Published: August 2024

Key Clinical MessageSuccessful management of a rare case involving both dens evaginatus and dens invaginatus in the same tooth, monitored over a 24‐month follow‐up.AbstractDens invaginatus (DI) is a congenital dental anomaly characterized by the presence of a tooth that resembles a “tooth within a tooth.” Conversely, dens evaginatus (DE) is a developmental anomaly distinguished by an additional tubercle or cusp on the tooth's crown. Both DI and DE can result in pulpal and periapical diseases in the affected tooth. This article presents a case of a healthy 14‐year‐old male with recurrent swelling under the chin and a wound with pus drainage on the right side of the submental area, associated with his left mandibular lateral incisor affected by both DI and DE. Clinical and radiographic examinations revealed that the tooth was necrotic and had a chronic apical abscess. Cone beam computed tomography (CBCT) confirmed Oehlers' type III DI and a talon cusp on the lingual surface of the same tooth. The patient underwent orthograde endodontic treatment. Passive ultrasonic activation of a 5.25% NaOCl solution and a mixture of Ca(OH)2 and a 2% chlorhexidine solution were utilized to effectively clean and eliminate the persistent pus discharge. After the resolution of the patient's symptoms, the apical third of the root canal and the invaginated space were filled with a plug of mineral trioxide aggregate (MTA), while the remaining root canal was filled using a sealer‐based obturation technique. A 24‐month follow‐up visit revealed complete bone regeneration in the previously affected periradicular tissues.
Unusual posterior elbow dislocation associated with radial head fracture managed nonoperatively in low‐ and middle‐income countries: A case report and literature review
Authors: Tumsifu Jean de Dieu Manegabe , Murhula Gauthier Bahizire , Munguakonkwa Paul Budema , Namugusha Alain Kabakuli , Bulabula Abasi Amisi , Maheshe Ghislain Balemba , Mgisha William , Kuhigwa Georges Toha , Cornu Olivier 
Published: August 2024

Key Clinical MessageIn LMICs, the nonoperative management of posterior elbow dislocation associated with radial head fracture is still a therapeutic option with favorable outcomes.AbstractElbow dislocation associated with radial head fracture is a rare lesion. The occurrence of such a lesion requires high energy trauma. The restoration of joint and radial head fracture that allows early mobilization is the best guarantee of a good functional outcome. We report a case of posterior elbow dislocation associated with radial head fracture managed by closed reduction and 1 week cast immobilization in neutral prono‐supination and 90°flexion followed by early mobilization was performed favorable functional outcome was obtained after 12 weeks. We review the different pattern of elbow dislocation and question the need of open reduction and internal fixation for displaced radial head fractures.
Chronic uterine inversion: Mimicking uterine cervical polyp or leiomyoma
Authors: Birge Ozer , Saibou Hamsatou , Kayar Ilkan 
Published: August 2024

Key Clinical MessageThe diagnosis of chronic uterine inversion occurs after birth or secondary to pathologies of the pelvic region organs. Especially, the diagnosis and treatment of isolated chronic inversion rapidly under appropriate conditions seem to reduce maternal morbidity and mortality.AbstractChronic uterine inversion is a rare clinical diagnosis and difficult to diagnose and treat. This is a 22‐year‐old patient with no particular history known for a month for uterine fibroid with a polyp, who gave birth through the cervix in the context of subfertility for a year. Non puerperal uterine inversion is a rare clinical condition, and it should be kept in mind that this may be uterine inversion when mass lesions causing clinical complaints are detected, especially in the vulva, vagina, and cervix uteri region. The quality of life of the patients is increased by reducing the morbidity and mortality rates by making a diagnosis with a good clinical and ultrasonographic evaluation.
Increased lung field permeability in young patients
Authors: Tanaka Ayaka , Hamakawa Masamitsu , Ishida Tadashi 
Published: August 2024

Key Clinical MessageWhen the chest radiograph of a young patient shows lung hyperlucency, it is important to obtain a detailed clinical history of any previous episodes of childhood infection. Previous chest radiographs should be reviewed to determine whether the condition is congenital or acquired, and thus assist in a diagnosis of SJMS.
Cutaneous leishmaniasis mimicking psoriasis: A case report
Authors: Karaja Saja , Halloum Mai , Karaja Shahed , daher alhussen Abdul hadi , Qatza Ayham , Mansour Sanaa , Almasri Alae Aldin 
Published: August 2024

Key Clinical MessageScalp lesions associated with psoriasis and cutaneous leishmaniasis can be clinically indistinguishable, leading to misdiagnosis. Herein, we highlight a 70‐year‐old male initially misdiagnosed with psoriasis but subsequently confirmed to have cutaneous leishmaniasis. This emphasizes the importance of considering alternative diagnoses, especially in atypical presentations, to ensure accurate treatment.
A case of septic arthritis of the manubriosternal and chondrosternal joints
Authors: Randrianarisoa Rova Malala Fandresena , Andrianiaina Armel Mamihaja , Radinasoa Rajo Païdia , Vololontiana Hanta Marie Danielle 
Published: August 2024

Key Clinical MessageAlthough rare, septic arthritis of the manubriosternal and chrondrosternal joints should be considered in the presence of a parasternal mass with fever and/or local signs of inflammation. MRI has an important role in the diagnosis. Blood cultures should be obtained routinely. We report an 80‐year‐old man with painful sternal swelling and fever. Chest MRI and PET scan were consistent with septic arthritis of the manubriosternal and chrondrosternal joints. Blood cultures were positive for Staphylococcus aureus. The evolution was favorable under antibiotic therapy for 6 weeks.
The role of idiosyncratic deals in shaping retirement preferences of older workers: A psychological needs perspective
Authors: Hasselgren Bune Caroline , Jonsson Robin 
Published: August 2024

AbstractThis study examines how idiosyncratic deals (I‐deals) affect older workers’ preferred retirement age. Drawing on basic psychological needs theory, we specifically investigate the role of need satisfaction at work in explaining this relationship. By means of confirmatory factor analysis (CFA) and structural equation modeling (SEM), our hypotheses were tested in a sample of 4234 employees aged 65 years or older in a large public‐sector organization in Sweden. The findings suggest that employees with negotiated I‐deals concerning schedule flexibility or financial incentives experienced greater need satisfaction and preferred to retire later than those without such deals. Additionally, task and work responsibility deals were shown to directly and positively predict retirement preferences. This study offers new insights into how I‐deals could delay the preferred retirement by fulfilling basic psychological needs. It may thereby inform interventions to increase need satisfaction at work and the implementation of policies for recruiting and retaining older workers.
Functionalized Metal‐Organic Framework for NADH Regeneration by Hydrogen in a Redox Flow Bioreactor
Authors: Li Feifei , Housseini Wassim EI , Zhu Qunyan , Zhang Lin , Yang Wensheng , Etienne Mathieu 
Published: August 2024

AbstractThe electrochemical regeneration of reduced nicotinamide adenine dinucleotide (NADH) using [Rh(Cp*)(bpy)Cl]+ holds significant promise for the industrial synthesis of chiral chemicals. However, challenges persist due to the high consumption of NADH and the limited efficiency of its cyclic regeneration, which currently hinder widespread application. To address these obstacles, based on in‐situ growth of 3D ordered metal‐organic framework (NU‐1000) on the surface of graphite felt, [Rh(Cp*)(bpy)Cl]+ were immobilized on the Zr6 nodes of NU‐1000 by solvent‐assisted ligand incorporation (SALI), and applied in a flow bioreactor. Moreover, we employ a gas diffusion electrode (GDE) to oxidize H2, providing a clean proton source for the electrochemical regeneration of NADH. Consequently, highly efficient enzymatic electrocatalytic synthesis of L‐lactate was achieved when coupled with L‐lactate dehydrogenases (LDH) as a model reaction, and the total turnover number (TTN) reached 19600 and 1750 for [Rh(Cp*)(bpy)Cl]+ and NAD+ after 48 h, corresponding to a high turnover frequency (TOF) of 2350 h−1 and 210 h−1 for [Rh(Cp*)(bpy)Cl]+ and NAD+, respectively. This work provides new insights for the construction of efficient enzymatic electrosynthesis systems in industrial production.
Platinum(II)‐Salphen Complexes as DNA Binders and Photosensitisers
Authors: Bartlett Molly , Burke Joseph , Sherin Petr , Kuimova Marina K. , Barahona Mauricio , Vilar Ramon 
Published: August 2024

AbstractCurrent anticancer therapies suffer from issues such as off‐target side effects and the emergence of drug resistance; therefore, the discovery of alternative therapeutic approaches is vital. These can include the development of drugs with different modes of action, and the exploration of new biomolecular targets. For the former, there has been increasing interest in drugs that are activated by an external stimulus (e. g. light irradiation) to generate cytotoxic chemicals such as reactive oxygen species (ROS). For the latter, significant efforts are being directed to explore non‐canonical DNA and RNA structures (e. g. guanine‐quadruplexes), as alternative biomolecular targets. Herein we report the synthesis of a library of 21 new platinum(II)‐Salphen complexes (square planar platinum(II) complexes coordinated to tetradentate O,N,N,O‐Schiff base ligands), and the investigation, for all complexes, of their photophysical and photochemical properties, their interactions with duplex and quadruplex DNA, and their cytotoxicity against HeLa cancer cells both in the dark and upon light irradiation. Thanks to the intrinsic phosphorescence of the platinum(II) complexes, confocal microscopy was used for six of the complexes to determine their cellular permeability and localisation in two cancer cell lines (HeLa and U2OS). Altogether, these studies have allowed us to identify two lead platinum(II) complexes with high guanine‐quadruplex DNA affinity and selectivity, good cell permeability and nuclear localisation, and high cytotoxicity against HeLa cancer cells upon irradiation with no detected cytotoxicity in the dark.
Dynamic Life Cycle Assessment of Integrated Production of Steel and Methanol
Authors: Gaikwad Ankur , Schlüter Stefan 
Published: August 2024

AbstractThe dynamic carbon footprint profile of methanol production from steel mill gases is affected by fluctuations of steel mill gas flow rates and compositions, as well as the composition of electricity mix. The cross‐industrial network of steel mill, gas conditioning, hydrogen production, chemical synthesis, and power generation was simulated under dynamic conditions. Dynamic life cycle assessment (LCA) was carried out for computing the dynamic carbon footprint profile in 15‐min resolution for the integrated system of steel and methanol production. The dynamic LCA indicated that the CO2 emissions in a power plant, electrolytic hydrogen demand, and variations in electricity mix were the major drivers of the fluctuations in the total carbon footprint. Dynamic LCA is useful for quantifying temporal uncertainty in environmental impacts. This insight can be used to analyze uncertainty in impacts for downstream products, processes, and use cases.
Machine learning and metaheuristics in microfluidic transport characterization and optimization: CFD and experimental study integrated with predictive modelling
Authors: Kouhkord Afshin , Amirmahani Moheb , Hassani Faridoddin , Naserifar Naser 
Published: August 2024

AbstractThis study presents a comprehensive numerical and experimental analysis on microfluidic cell lysis through computational fluid dynamics (CFD), data‐driven modelling, and multi‐objective optimization. The proposed intelligent framework integrates artificial intelligence and CFD for data generation and extraction, alongside machine learning analysis and experimental studies for transport phenomena characterization in the cell lysis process. The framework explores compound effects of various inflow Reynolds numbers and geometrical parameters, including obstacle configurations and microchannel thickness. It shows substantial effects on flow patterns and mixing in varied microfluidic designs. A surrogate model, developed via central composite design, exhibits high accuracy in assessing system functionality (). The height of the implemented baffles from its lower value to the upper bound resulted in more than 42% and 14% increase in the mixing index at low and high Reynolds numbers, respectively, with minimal impact on pressure drop. The framework introduces data‐driven modelling coupled with multi‐objective optimization by desirability function (DF), non‐dominated sorting genetic algorithm (NSGA‐II), and differential evolution (DE). In the optimization of microfluidic processes, machine learning algorithms outperform desirability‐based methods, and the DE algorithm surpasses the NSGA‐II. An optimum micromixing reducing the mixing length by over 50% and mixing index above 97% achieved, fabricated, and experimental investigations conducted to validate numerical process. Through the precise control of microfluidic variables and the exploitation of microtransfer phenomena, it is possible to enhance the efficiency and selectivity of cell lysis. This not only improves the accuracy of diagnostic information but also opens up new avenues for personalized medicine and therapeutic development.
Selective and efficient removal of phosphate from aqueous solution using activated carbon‐supported Mg–Fe layered double oxide nanocomposites
Authors: Bezza Fisseha A. , Brink Hendrik G. , Chirwa Evans M. N. 
Published: August 2024

AbstractIn the face of the continuous development of novel adsorbents, developing robust adsorbents with high efficiency, strong phosphate selectivity, high regenerability, and cost effectiveness is a scientific challenge. In the present study, an activated carbon‐supported MgFe2O4‐layered double hydroxide (AC@ MgFe2O4‐LDH) derived Mg–Fe layered double oxide (AC@ MgFe2O4‐LDO) nanocomposite was synthesized at various temperatures and its potential application for phosphate adsorption was investigated. The nanocomposite exhibited a hierarchical mesoporous structure with a Brunauer–Emmett–Teller (BET) specific surface area of 193 m2/g and a narrow per‐size distribution of ~2 nm. AC@MgFe2O4‐LDO exhibited a high point of zero charge (pHpzc) value of 9.8 and robust phosphate adsorption potential over a wide pH range of 4–9 due to its high pH buffering capacity. The effects of adsorbent dose, layered double hydroxides (LDH) calcination temperature, initial phosphate concentration, contact time, and temperature on the phosphate adsorption capacity of the adsorbent were investigated. In the present study, up to 99.0% removal of phosphate was achieved at a 4 g/L adsorbent dosage in 4 h at pH 7 and 30°C. An adsorption kinetics study revealed that the adsorption of phosphate by AC@MgFe2O4‐LDO reached equilibrium within 240 min, with the kinetic experimental data fitting well with pseudo‐first‐order kinetics (r2 >0.99). The Langmuir adsorption isotherm model fit the experimental data well, with a maximum adsorption capacity of 25.81 mg/g. The adsorbent displayed strong phosphate selectivity in the presence of competing anions, and the study demonstrated that AC@MgFe2O4‐LDO has promising potential for efficient phosphate adsorption over a wide pH range.
Hydrodynamics and mass transfer studies on plate‐type microchannel reactor for liquid–liquid systems
Authors: Karekar Pranita A. , Dalvi Vishwanath H. , Gadipelly Chandrakanth R. , Patwardhan Ashwin W. 
Published: August 2024

AbstractThis work reports hydrodynamic and mass transfer studies on a novel microreactor that can passively break up liquid–liquid slugs using judiciously placed internals. The reactors were fabricated in stainless steel (SS‐316 L, hereafter SS) and PMMA (hereafter acrylic). The performance of both is comparable to the current state‐of‐the‐art in microreactor technologies. A separated flow model is proposed to estimate the pressure drop for two‐phase flows, with a mean absolute error (MAE) of 15.44% in SS and 19.83% in acrylic, respectively. Pulse tracer experiments were performed for residence time distribution (RTD) studies. They are fitted to a model for the prediction of RTD for single and two‐phase flows. The results obtained from mass transfer experiments show that the volumetric mass transfer coefficient () in the case of SS reactor is, on average, 2.4 times higher than acrylic. A correlation is developed for estimating the based on total velocity and phase fraction, providing better fits than the models based on energy dissipation. All studies show that wall characteristics significantly impact the hydrodynamics and mass transfer phenomena since the pressure drop and the are greater in (the rougher) SS than in acrylic.