bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating miRNA-21 as early potential diagnostic biomarker for acute myocardial infarction: a meta-analysis
Authors: Wang Ke , Li Kai , Li Zhuoyuan , Yan Xizhang 
Published: August 2024

IntroductionThere exists a knowledge gap concerning the clinical significance of miRNA-21; therefore, in the present study, we aimed to estimate the diagnostic and prognostic accuracy and sensitivity of miRNA-21 in acute myocardial infarction (AMI) by performing an evidence-based meta-analysis of previous AMI-related clinical studies.MethodsChinese and English literature published before April 2024 were searched, and data were reviewed and extracted. After quality appraisal, the STATA 16.0 software was used for the effect size analysis of the various treatments described in the literature.ResultsA total of 14 valid documents were retrieved from 562 studies. The results of the systematic review revealed that for the patients with AMI vs. those without non-AMI, the aggregated odds ratio reached 5.37 (95% confidence interval 3.70–7.04). The general sensitivity and specificity for the circulating miRNA-21 levels in diagnosing AMI were 0.83 and 0.81, respectively.DiscussionThus, the meta-analysis of 14 AMI-related clinical trials highlighted that miRNA-21 may serve as a promising biomarker for diagnosing AMI.
Unraveling the interplay: early-stage atrial functional mitral regurgitation and left atrial electrical substrate in atrial fibrillation patients
Authors: Mohsen Yazan , Rottländer Dennis , Großmann Nora , Lewandowski Nicole , Horlitz Marc , Stöckigt Florian 
Published: August 2024

BackgroundAtrial fibrillation (AF) triggers atrial remodeling, impacting atrial function and ablation efficacy. This remodeling leads to atrial cardiomyopathy and dilatation, linked to mitral regurgitation, forming atrial functional mitral regurgitation (aFMR). Our study explores the relationship between early-stage-aFMR and the atrial electrical architecture, focusing on left atrial bipolar voltage and low-voltage areas (LVAs) in AF patients.MethodsWe enrolled 282 patients undergoing redo-PVI after AF recurrence post-PVI. Echocardiography was performed prior to ablation, and only patients with no, mild, or mild-to-moderate aFMR were included. Ablation used radiofrequency and a 3D mapping system, with atrial voltage documented on each atrial wall. LVAs were calculated using high-density maps, and patients were followed for 15 months.ResultsSignificant differences in left atrial voltage and LVA extent were observed based on aFMR severity. Patients with aFMR 1 + had significantly lower atrial voltage compared to no-aFMR, but no significant increase in LVAs. Patients with aFMR 2 + showed lower voltage amplitudes in all atrial regions and larger LVAs compared to no-aFMR patients. AF recurrence was significantly higher in the aFMR group (62.9% vs. 48.3%, p = 0.027) within 1 year. aFMR was associated with AF recurrence after adjusting for sex, age, and AF types (HR: 1.517, 95% CI: 1.057–2.184, p = 0.025).ConclusionaFMR in AF patients may indicate progressive atrial remodeling and left atrial cardiomyopathy, characterized by reduced atrial voltage and increased LVAs. aFMR is linked to PVI outcomes, suggesting its consideration in AF therapy decision-making.
Successful percutaneous coronary intervention of left main coronary artery dissection following mechanical aortic valve replacement surgery: a case report and literature review
Authors: Vu Vu Hoang , Truong Hung Phi , Tran Hoa , Cao Khang Dang , Duong Bao Thien , Tran Thuy Thanh Thi , Truong Binh Quang 
Published: August 2024

BackgroundIatrogenic left main coronary artery (LMCA) dissection resulting from cardiac surgery is a rare complication. Its early detection is challenging and often poses a significant threat to the patient's life. However, evidence regarding the most effective management strategy for this condition remains limited at present.Case presentationWe present a case of 65-year-old female patient who developed cardiogenic shock after mechanical aortic valve replacement surgery associated acute myocardial infraction. Despite concurrent coronary artery bypass graft (CABG) surgery, the patient's condition remained unimproved. Subsequent coronary angiography revealed extensive LMCA dissection involving the left circumflex (LCx) artery. Percutaneous coronary intervention (PCI) guided by intravascular ultrasound (IVUS) led to an immediate improvement in hemodynamic status. The patient was successfully discharged after 22 days of treatment.ConclusionsIatrogenic LMCA dissection is an uncommon complication following cardiac surgery. It can manifest in a variety of ways, including as incidental findings, cardiogenic shock or sudden cardiac arrest. The precise prevalence rates of causes linked to cardiac surgery remain largely unknown due to the scarcity of reported cases and the absence of research on this issue. Currently, a definitive management strategy for this condition has not been established. However, previous reported clinical cases provide insight that CABG could be considered if coronary artery dissection is detected during cardiac surgery. Upon postoperative identification, diagnostic coronary angiography and PCI may be feasible alternatives.
Task-irrelevant visual distractions and mindful self-regulated learning in a low-stakes computer-based assessment
Authors: Wolff Sarah M. , Wright Daniel B. , Hatcher Wilson J. 
Published: August 2024

IntroductionThere is a growing concern about the threat of distractions in online learning environments. It has been suggested that mindfulness may attenuate the effects of distraction. The extent to which this translates to academic performance is under investigation. We aimed to investigate the relationship between task-irrelevant visual distraction, time pressure, and mindful self-regulated learning in the context of a low-stake computer-based assessment.MethodsThe study sampled 712 registered users of Prolific.co who were prescreened, current undergraduate university students. After data quality screening, 609 were retained for analyses. A 2 × 2 between-subjects design was used. Participants were randomly assigned to the following groups: (1) a control condition, (2) a distract condition, (3) a time pressure condition, or (4) a distract and time pressure condition. All participants completed reading comprehension questions, demographic questions, and the Mindful Self-Regulated Learning Scale.ResultsPresenting a visual distraction increased self-reported distraction and having a clock present increased self-reported time pressure. The distraction did not have a statistically significant effect on test performance. Mindfulness was negatively correlated with test performance, self-reported distraction, and self-reported time pressure.DiscussionContinuous task-irrelevant visual distractions may not be distracting enough to influence low-stakes testing performance, but they do influence self-perceptions.
Connecting mathematics and sports in informal learning spaces
Authors: Turner Erin , Buxner Sanlyn , Miller Seneca B. , Baze Christina , Valerdi Ricardo 
Published: August 2024

IntroductionThere is a critical need to develop innovative educational strategies that engage youth in meaningful mathematics learning, particularly students from groups that have been historically marginalized in science, technology, engineering, and mathematics (STEM). In this study, we explore youths’ participation in two collaborative projects from the Growing Mathletes curriculum which combines baseball contexts and mathematics. Our goal was to understand the potential of these projects to support youths’ engagement with mathematical ideas and practices, and the extent to which youth leveraged a range of resources, including prior experiences and funds of knowledge, to inform their decisions and understanding.MethodsThe Design a Stadium and Baseball Team Roster projects were implemented in two afterschool setting sites and two summer program sites with 102 youth of all genders in grades 3 to 8. Data sources included video recordings of youth participation in the project, project artifacts, and youth interviews.ResultsWe found the projects contained specific features that supported youths’ engagement in three specific mathematical practices: (1) make sense of problems and persevere in solving them, (2) reason abstractly and quantitatively, and (3) construct viable arguments and critique the reasoning of others. Additionally, there is evidence that while engaging in these projects youth drew on their own funds of knowledge to inform their decisions and understanding.ConclusionOur findings point to key implications for researchers, educators, and curriculum developers in informal STEM learning spaces.
Neutrophil-to-lymphocyte ratio as a predictor of all-cause and cardiovascular mortality in coronary heart disease and hypertensive patients: a retrospective cohort study
Authors: Song Songhong , Chen Liwen , Yu Rong , Zhu Jinxiu 
Published: August 2024

BackgroundTo date, no studies have investigated the correlation between the neutrophil-to-lymphocyte ratio (NLR) and the long-term risk of mortality in individuals with both coronary heart disease (CHD) and hypertension. This study aims to evaluate the association between NLR and all-cause and cardiovascular mortality among this patient population.MethodsNational Death Index (NDI) and National Health and Nutrition Examination Survey (NHANES 2001–2018) were the data sources. A nonlinear association between the NLR and mortality risk was shown by restricted cubic spline (RCS) analysis. Using a weighted Cox proportional hazards model, we quantitatively evaluated the effect of NLR on mortality risk.The capacity of NLR to forecast survival was assessed by evaluating time-dependent receiver operating characteristic (ROC) curves. A mediating influence analysis was conducted to assess the influence of NLR on mortality through eGFR as a mediator.ResultsThe study involved a total of 2136 individuals. During the median follow-up interval of 76.0 months, 801 deaths were recorded. The RCS analysis showed NLR and mortality risk to have a nonlinear relationship. Two groups were established based on the participants’ NLR levels: a group with high NLR (NLR &gt; 2.65) and a group with low NLR (NLR &lt; 2.65). After adjusting for potential confounding factors, the Cox proportional hazards model revealed that participants with an increased NLR faced a significantly higher risk of cardiovascular mortality. (HR 1.58, 95% CI 1.33–1.82, p &lt; 0.0001) and all-cause mortality (HR 1.46, 95% CI 1.30–1.62, p &lt; 0.0001). An analysis of interactions and data stratification corroborated the validity of our findings. eGFR was identified as a partial mediator in the association between NLR and mortality rates, contributing 12.17% and 9.66% of the variance in all-cause and cardiovascular mortality, respectively. The predictive performance for cardiovascular mortality was quantified using ROC curves, with respective AUC values of 0.67, 0.65, and 0.64 for predictions over 3, 5, and 10 years. The AUC values for all-cause mortality were 0.66, 0.64, and 0.63 for the same time frames.ConclusionFor patients with CHD and hypertension, an elevated NLR serves as an independent prognostic indicator for both all-cause and cardiovascular mortality.
Use of graphene oxide for the removal of norfloxacin and ceftriaxone antibiotics from aqueous solution: process optimization using response surface approach
Authors: Li Zhihui , Zhang Shuhang , Zhu Guina , Xing Jie 
Published: August 2024

In this research, graphene oxide (GO) as an adsorbent was used to remove norfloxacin and ceftriaxone antibiotics from aqueous solutions. All environmental factors affecting removal (e.g., pH, adsorbent mass, contact time, and concentration) were optimized in a discontinuous system. The design of experiments and the optimization of variables were carried out using the response surface method (RSM). The results of the analysis of variance (ANOVA) and the regression coefficients of the quadratic terms indicated that the responses were significantly affected by all the studied variables (P &lt; 0.05). Also, the quadratic polynomial model results corresponded to empirical data with a high coefficient of determination (i.e., R2 ˃ 0.99 for both antibiotics). Besides, the adjusted R2 (R2-adj ˃ 0.98 for both antibiotics) was close to R2 values, indicating a good and acceptable statistical model. According to the results, the optimal removal of antibiotics by GO occurs in conditions of pH of 8, 0.034 g of the adsorbent mass, a sonication time of 20 min, and a concentration of 25 mg L−1. In these conditions, the maximum removal efficiencies of ceftriaxone and norfloxacin were equal to 95.87% and 98.64%, respectively. GO was recovered in five adsorption/desorption processes, and the removal efficiency declined very slightly after using the adsorbent for five cycles. Therefore, it is concluded that GO is an efficient and acceptable adsorbent for removing ceftriaxone and norfloxacin from aqueous environments.
Professionalism and associated factors among nurses working in Hawassa city public hospital, Sidama, Ethiopia
Authors: Abebe Boe Eyerusalem , Mekonnen Shiwangizaw , Fako Thomas , Aschale Wale Mastewal , Tade Meku , Tsega Chekol Aklile 
Published: August 2024

BackgroundThe foundation of the global healthcare system is nurses, and professionalism in nursing is a basic idea that helps patients, organizations, and people. Studies that have been published in Ethiopia, though, are limited, out-of-date, and poorly documented, especially when it comes to the study setting. Because of this, this study aimed to close a knowledge gap on the level of professionalism in public hospitals in Sidama, Ethiopia.ObjectiveThis study aimed to assess professionalism and associated factors among nurses working in Hawassa city public hospitals, Hawassa, Ethiopia.MethodsAn institutional-based cross-sectional study was conducted among nurses working in Hawassa city public hospital from June to July 2022. A computer-generated simple random sampling technique was used to select 413 study participants. The level of professionalism was assessed through a self-administered questionnaire, using the guidelines of the Registered Nurses Association of Ontario. All the loaded data using Epi-data version 4.6 were exported to a statistical package for social science. An ordinal logistic regression analysis was used to identify the associations between the outcome and predictor variables. The statistical significance of the factors influencing the outcome variable was declared in multivariate logistic regression analysis using an adjusted odds ratio at a 95% confidence interval with a p-value &lt;0.05.ResultsA total of 405 nurses participated in the study, with a response rate of 98%. Of the total participants, more than half were females (55.3%). The level of professionalism was found to a moderate level. There was a strong link between completing their degree in a governmental institution, being part of a professional organization, serving for several years, and having a BSc or above qualification with a moderate level of professionalism.ConclusionWe found a moderate level of professionalism among nurses working in the study setting. This suggests that the Regional Health Bureau should collaborate with other responsible bodies to develop various opportunities for nursing staff to increase their professionalism. The minister of health should be focused on private college nurses, nurses lacking the association, and the qualification of the profession.
Predicting the clinical prognosis of acute ischemic stroke using machine learning: an application of radiomic biomarkers on non-contrast CT after intravascular interventional treatment
Authors: Gu Hongxian , Yan Yuting , He Xiaodong , Xu Yuyun , Wei Yuguo , Shao Yuan 
Published: August 2024

PurposeThis study aimed to develop a radiomic model based on non-contrast computed tomography (NCCT) after interventional treatment to predict the clinical prognosis of acute ischemic stroke (AIS) with large vessel occlusion.MethodsWe retrospectively collected 141 cases of AIS from 2016 to 2020 and analyzed the patients' clinical data as well as NCCT data after interventional treatment. Then, the total dataset was divided into training and testing sets according to the subject serial number. The cerebral hemispheres on the infarct side were segmented for radiomics signature extraction. After radiomics signatures were standardized and dimensionality reduced, the training set was used to construct a radiomics model using machine learning. The testing set was then used to validate the prediction model, which was evaluated based on discrimination, calibration, and clinical utility. Finally, a joint model was constructed by incorporating the radiomics signatures and clinical data.ResultsThe AUCs of the joint model, radiomics signature, NIHSS score, and hypertension were 0.900, 0.863, 0.727, and 0.591, respectively, in the training set. In the testing set, the AUCs of the joint model, radiomics signature, NIHSS score, and hypertension were 0.885, 0.840, 0.721, and 0.590, respectively.ConclusionOur results provided evidence that using post-interventional NCCT for a radiomic model could be a valuable tool in predicting the clinical prognosis of AIS with large vessel occlusion.
Association between 35 blood and urine biomarkers and oral leukoplakia: a two-sample Mendelian randomization study
Authors: Ouyang Yu-long , Wei Jing , Liu Mei-yan , Zhang Yi , Liu Sheng-hui , Feng Hong-chao 
Published: August 2024

BackgroundSeveral existing studies have shown a correlation between some of the blood and urine biomarkers and oral leukoplakia (OLK). However, the causality of this relationship remains uncertain. Thus, this study aimed to examine the causal association between 35 blood and urine biomarkers and OLK.MethodsSingle nucleotide polymorphisms (SNPs) associated with 35 blood and urine biomarkers were selected as instrumental variables (IVs) using a two-sample Mendelian randomization(MR) study to assess the causal relationship between the biomarkers and the risk of oral leukoplakia. We used the inverse variance weighted (IVW) method as the main analysis. Furthermore, several sensitivity analyses were performed to assess heterogeneity, horizontal pleiotropy, and stability.ResultsBased on the selection criteria of the Inverse Variance Weighted (IVW) method, the analysis found that 5 blood and urine biomarkers were significantly associated with the development of leukoplakia, of which the results of IVW showed that abnormalities of Apolipoprotein B (Apo B), Cholesterol, Low-density Lipoprotein (LDL), Triglycerides (TG) promoted the development of oral leukoplakia, and Non Albumin Protein (NAP) had a protective effect on the development of oral leukoplakia. We then performed a Bonferroni correction for these results, and after correction Apo B was still causally associated with the development of oral leukoplakia (IVW P&lt;0.0007), whereas the other four biomarkers could only provide some evidence of predisposition.ConclusionOur two-sample Mendelian randomization study supports the existence of a causal relationship between these five blood and urine biomarkers and the occurrence of oral leukoplakia, and provides evidence for a number of risk and protective factors for the development of oral leukoplakia; however, the definitive mechanisms for the occurrence and development of oral leukoplakia still remain to be elucidated, and further studies on these relevant mechanisms are still needed.
Assessment of executive functions using a 3D-video game in children and adolescents with ADHD
Authors: Takahashi Nagahide , Ono Tomihiro , Omori Yuka , Iizumi Misuzu , Kato Hidekazu , Kasuno Shinichi , Persing Barry , Tsuchiya Kenji J. 
Published: August 2024

ObjectiveExecutive functions are important factors that affect the well-being of children with ADHD. Therefore, inclusion of a convenient assessment of executive dysfunction in diagnosis and treatment of ADHD patients is warranted. However, executive dysfunction assessment presently relies on lab-based neuropsychological tests and symptom rating scales. The present study examined the potential of a 3-D action puzzle video game to reflect ecologically valid executive functioning in pediatric ADHD patients.MethodsParticipant gameplay metrics were compared to both their Cambridge Neuropsychological Test Automated Battery (CANTAB) and Conners 3 Parent Form’s executive functioning subscale scores. Participants consisted of 33 ADHD and non-ADHD patients aged 8-21.ResultsMetrics from gameplay were associated with distinct CANTAB test scores, and a composite score from gameplay was significantly correlated with executive dysfunction from Conners 3.ConclusionFor children with ADHD, cognitive domains related to executive function and overall real-life executive functioning appear to both be measurable via video games. It may be possible to develop individualized behavioral therapy based on the quantitative data obtained from the video game used in this study.
Positive cardiovascular health: longitudinal investigation of sustained health behavior in a cross-lagged model
Authors: Ocsovszky Zsofia , Ehrenberger Blanka , Berenyi Blanka , Assabiny Alexandra , Otohal Jozsef , Martos Tamas , Papp-Zipernovszky Orsolya , Hegedus Fanni , Merkely Bela , Csabai Marta , Bagyura Zsolt 
Published: August 2024

ObjectiveOur study focuses on the role of psychological states in the development of cardiovascular disease (CVD) and explores the potential of positive psychological factors in reducing CVD risk. While existing research has predominantly examined negative mental states and risk behavior, this longitudinal study takes a novel approach by investigating positive psychological wellbeing and its impact on sustained health behavior.MethodThe research involved participants (n = 502) with medium to high cardiovascular risk who underwent a comprehensive risk assessment in 2012, followed by written risk communication. Health behavior and psychological variables were measured in 2012 and 2019. A cross-lagged panel was employed to repeat measures of a cardiovascular health index with latent factors.ResultsResults indicated an excellent fit for the model (RMSEA = 0.0644, CFI = 0.936, TLI = 0.921, SRMR = 0.050), with significant associations between the observed variables (p &lt; 0.05) and created latent factors. Furthermore, the model implied significant bivariate correlations (p &lt; 0.05) between latent constructs of sustained health behavior and positive psychological states in 2012 and 2019. A significant regression relationship between Health Awareness Index 2012 and 2019, between Psychological wellbeing in 2012 and 2019 (B = 1.103 p = 0.038), latent factors could be identified (B = 1.103 p = 0.038) using cross-lagged panel model. Results highlighted the importance of cardiovascular health awareness, subjective risk perception, and self-directed efforts in facilitating health behavior change.ConclusionRelationships between psychological wellbeing and health awareness emphasize that positive experiences and reinforcement are crucial in sustaining optimal health behavior. Our findings offer a new perspective on cardiovascular risk screening and preventive interventions. Extending cardiovascular risk screening with psychological measures may broaden prevention opportunities by including psychological elements reinforcing positive psychological states. The findings suggest that an effective prevention program must consider stabilizing and maintaining positive psychological states to achieve lasting improvements in cardiovascular health.