bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the mechanisms of Shenmai injection against Chronic Obstructive Pulmonary Disease based on network pharmacology and molecular docking validation
Authors: LIU Xiaolin , GONG Jingru , Chen Yang , Lu Yi , Dan Qu , LU Huiping 
Published: August 2024

Abstract

Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The conventional therapies remain palliative and have various undesired effects. Shenmai injection (SMI) has shown positive effects on COPD, but its molecular mechanisms are still unclear. This study aims to investigate the bioactive ingredients and underlying mechanisms of SMI in treating COPD based on network pharmacology analysis and molecular docking validation.
Methods Active ingredients in SMI were sourced from the TCMSP, SymMap, and BATMAN-TCM databases, with their targets predicted using Swiss target prediction. Potential COPD targets were obtained from the GeneCards, OMIM and GEO databases. Cytoscape software was employed to construct the candidate component-target network for SMI in treating COPD. Furthermore, the functions and signaling pathways of shared targets between SMI and COPD were enriched by GO and KEGG analyses. Finally, molecular docking studies of key active ingredients and hub targets were performed using Autodock vina software.
Results A total of 28 active components were identified, corresponding to 606 targets, including 341 common targets shared by the active components and COPD. The top 10 hub targets were screened, namely STAT3, SRC, EGFR, HSP90AA1, AKT1, IL6, TNF, BCL2, JUN and CCND1. GO enrichment analysis yielded 127 entries for biological processes (BP), 32 for cellular components (CC), and 33 for molecular functions (MF). The significantly enriched iterms in BP, CC, and MF enrichment were associated with response to xenobiotic stimulus, plasma membrane, and protein serine/threonine/tyrosine kinase activity, respectively. KEGG enrichment analysis identified 189 significantly enriched pathways, primarily including pathways in cancer, PI3K-Akt signaling pathway and chemical carcinogenesis- receptor activation. These pathways play roles in the effect of SMI on treating COPD. Molecular docking results demonstrated the effective binding of the primary active ingredients (Ophiopogonanone A, Ruscogenin, Stigmasterol) to their respective targets (EGFR, AKT1, HSP90AA1).
Conclusion SMI treats COPD through a multi-component, multi-target, and multi-pathway synergistic network, providing a basis for further exploration of SMI's mechanisms in COPD treatment.
The snake-venom-nerve growth factor-inspired custom peptide downregulates two novel miRNAs (cel-miR-8207-3p and cel-miR-57-3p) for neuroprotection against paraquat-induced toxicity in Caenorhabditis elegans
Authors: Madhubala Dev , Khan Mojibur R. , Mukherjee Ashis K. 
Published: August 2024

Abstract

Parkinson's disease (PD) represents a significant global health challenge influenced by environmental factors and the accumulation of alpha-synuclein. MicroRNAs (miRNAs), crucial regulators of gene expression, play pivotal roles in neurodegenerative processes. This study is structured into two primary investigations. Firstly, miRNA microarray analysis in Caenorhabditis elegans treated with mouse 2.5 S-NGF and custom peptide (HNP) revealed distinct expression profiles, notably upregulating miR-1-3p and miR-255-3p compared to controls. Pathway analysis implicated these miRNAs in neuroprotective mechanisms, including PI3K, Wnt/β-catenin, and TGF signalling, while downregulated miRNAs were associated with apoptosis, p53, and innate immunity pathways. These results underscore the neuroprotective roles of NGF and HNP through miRNA-mediated mechanisms in C. elegans. Secondly, a comparative analysis of global miRNA profiles between paraquat-induced PD model worms and NGF/HNP-treated worms identified novel miRNAs and revealed inverse expression patterns indicative of miRNA profile restoration by NGF/HNP pre-treatment. Principal component and correlation analyses demonstrated distinct miRNA regulation profiles across treatments. Gene network analysis identified target mRNAs involved in diverse cellular processes, highlighting potential therapeutic roles of NGF and HNP in neurodegenerative diseases like Parkinson's, mainly through regulation of miR-4813-3p associated with α-synuclein clearance. These findings underscore the promise of NGF and HNP as therapeutic strategies targeting neurodegenerative mechanisms mediated by miRNAs.
High-Content Graphitic-N Self-Doped Porous Carbon Catalyst Derived from Seaweed for Efficient Oxygen Reduction Reaction
Authors: Zhang Junjie , Xia Maosong , Wang Jilong , Wu Chao , Li Shixin , Liu Long , Wei Wuguo 
Published: August 2024

Abstract

Academic interest in fuel cell technology is steadily increasing due to the demand for developing an affordable and effective biomass-derived catalyst for oxygen reduction reaction (ORR) to replace Pt-based catalysts. Nine groups of graphitic-N and pyridinic-N models are designed and analyzed using density functional theory (DFT). These results reveal that the ORR energy barriers for high-content graphitic-N models are only 0.10 eV and 0.11 eV, significantly lower than the 0.88 eV and 0.96 eV for pyridinic-N models, indicating that high-content graphitic-N structures are theoretically advantageous. High-protein seaweed is screened as a precursor to synthesize directionally high-content graphitic-N (3.56 at%) self-doped porous carbon ORR catalyst (S-850). The graphitic-N content of S-850 exceeds that of previously reported biomass-derived carbon-based ORR catalysts. Compared to 20% Pt/C (0.862 V and 5.60 mA cm− 2), S-850 (0.843 V and 5.24 mA cm− 2) exhibits only a 19 mV decrease in half-wave potential and a 0.36 mA cm− 2 decrease in limiting diffusion current density. S-850 also demonstrates superior stability and tolerance to methanol and CO compared to 20% Pt/C. Guided by DFT calculations, this study conducted the directional synthesis of high-performance, low-cost biomass-derived carbon-based ORR catalysts, offering a paradigm for future research.
Association of insufficiency fruits and vegetables consumption and cardiovascular diseases risk among beverage industrial workers and their spouses in Rwanda
Authors: Nsanzabera Charles , Bizumuremyi Colombe , Ndabihawenimana Désirée 
Published: August 2024

Abstract

Background
Cardiovascular diseases risk and premature death have been associated with low fruits and vegetables intake. Around 5.6 to 7.8 million of global premature deaths were declared due to insufficient intake of fruits and vegetables. The objective of this study was to assess the association between fruits and vegetables intake and fatal and non-fatal cardiovascular disease (CVD) risk.
Methods
Employing a cross-sectional analytical design, 440 study participants aged between 30 and 75 years participated in this study using Cochrane sample size formula and stratified random sampling combined with simple random sampling. Stepwise questionnaire, clinical forms and biological blood samples were used to get socio-demographic, fruits, and vegetables(F&V) data and prior information for predicting the cardiovascular risk with cox regression analysis through Framingham general risk score. Chi-square and logistic regression statistical analysis were used to assess the association between F&V intake and categorized cardiovascular diseases risk (low CVD risk:<10% and elevated CVD risk > = 10%). The significance threshold was set at p < 0.05 and 95%CI.
Results
The findings of this study revealed that the mean age was 44.92 years with interquartile range of IQR: 45(38-51.75). Around 75.9% of study participants consumed vegetables for two days and fewer in a typical week, and 79.8% of participants were found to consume less than one serving. Additionally, consuming vegetables below three days in a typical week was associated with elevated cardiovascular disease risk ( > = 10%) with AOR: 5.869, 95% CI: 2.710-12.714, p < 0.001. Having less than one serving of vegetables or consuming none were associated with a twofold increase in elevated cardiovascular disease risk ( > = 10%) with AOR: 2.135, 95% CI: 1.136–4.010, p = 0.01. Moreover, consuming less than one serving of fruits was associated with a fourfold increase in elevated cardiovascular disease risk ( > = 10%) with AOR: 4.41, 95% CI: 1.938–10.042, p < 0.001.
Conclusion
This study concludes that consuming a low quantity of servings and infrequent intake of fruits and vegetables in a typical week is associated with an elevated risk of cardiovascular diseases ( > = 10%).
The Critical Role of Valuation in Supporting Phu Quoc's Tourism Revenue
Authors: Ngo-Hoang Dai-Long 
Published: August 2024

Abstract

Phu Quoc, a large island in Vietnam's Southwest Sea, holds a strategic position in terms of economics, politics, defense, and security. The island is endowed with a favorable climate, diverse terrain, and rich biological resources, which have made tourism a key driver of local development. This study aims to estimate the economic value generated by tourism activities on Phu Quoc Island, thereby emphasizing the potential for ecotourism. The research employs the Zonal Travel Cost Method (ZTCM) to assess this value, utilizing data from the People's Committee of Phu Quoc district and a sample of survey respondents. The findings reveal the significant economic contributions of ecotourism, demonstrating the island's capacity to generate substantial tourism revenue. The study concludes that Phu Quoc has immense potential for generating tourism welfare, provided that infrastructure is well-developed, recreational activities are diversified, and the ecological environment is sustainably protected. These insights offer valuable guidance for policymakers in planning and managing the sustainable development of ecotourism on Phu Quoc Island.
Titanium Substitutions in Garnet at Magmatic, Granulite Facies, and High-Pressure Granulite Facies Conditions
Authors: Ague Jay J. , Keller Duncan S. , Ackerson Michael R. , Holycross Megan 
Published: August 2024

Abstract
Crystallographically oriented lamellar to acicular rutile ± ilmenite inclusions in garnet may record important information about the pressure (P), temperature (T), and petrotectonic evolution of the lithosphere. However, reading this record requires a robust understanding of titanium (Ti) substitution mechanisms and solubility in garnet. To this end, we examine the Ti substitution systematics revealed by 87 garnet analyses from previously published experimental studies relevant for granulites, high-pressure granulites, and deep crustal magmatic rocks. The experimental P–T conditions range mostly between 850–1230 °C and 1.0–2.7 GPa; four 3.2 GPa, 1075–1150 °C ultrahigh-P, ultrahigh-T examples are also included. We find that normalizing garnet formulas based on 2 octahedral sites per 12 oxygens provides better Fe3+ estimates than the standard 8-total-cation scheme. The Fe3+ must be constrained as both it and Ti substitute on octahedral sites. Graphical analysis reveals that the main substitutions are Tschermak-Ti (VITi4+ + IVAl3+ ↔ VIAl3+ + IVSi4+) and Andradite (VIAl3+ ↔ VIFe3+), with lesser but nonetheless important contributions by Andradite-Ti (VITi4+ + IVAl3+ ↔ VIFe3+ + IVSi4+) and alkali-Ti (VITi4+ + VIII(Na+,K+) ↔ VIAl3+ + VIIIM2+). Here, VIIIM2+ denotes dodecahedrally coordinated divalent cations (Ca, Fe2+, Mg, Mn). We also posit a small role for Ti substitution coupled to dodecahedral vacancies. These inferences were independently tested using a Monte Carlo modeling procedure developed herein that quantitatively reproduces both the nature and extent of the observed substitutions. We also compared the experimental data with a representative suite of natural garnet analyses. In general, the natural garnets have far lower Ti and alkali (Na ± K) contents than the experimental ones. We attribute this to Ti and alkali loss in nature during exhumation and cooling by processes including diffusion and interface-coupled dissolution-reprecipitation. Some fraction of the lost Ti can be hosted by exsolved precipitates of crystallographically oriented rutile ± ilmenite. However, in many cases, these are absent and the Ti must have left the garnet structure entirely. The lost alkalis may be hosted by exsolved amphibole or mica precipitates, but these are relatively uncommon suggesting that alkalis are typically transferred from garnet to the matrix or to non-precipitate inclusions.
Faktor-Faktor yang Memengaruhi Financial Statement Fraud
Authors: Nuraya Adinda Sofi , Fachriyah Nurul Sofi 
Published: August 2024

Despite the lowest prevalence, according to a survey by ACFE in 2022, financial statement fraud causes the highest average total loss compared with other types of fraud. This research aims to provide the empirical evidence of the factors affecting financial statement fraud. The dependent variable is represented by the F-Score, and the independent variables represent factors affecting the financial statement fraud, including financial target, external pressure, ineffective monitoring, auditor changes, board of director’s changes. Using State-Owned Enterprises listed on the Indonesia Stock Exchange in 2019-2022as a sample,the research results shows that financial target has a positive effect on financial statement fraud, while auditor changes has a negative effect on financial statement fraud.
PENGARUH ROYALTI STREAMING MUSIK SPOTIFY, PERTUNJUKAN LANGSUNG, DAN SESSION WORK TERHADAP PENDAPATAN MUSISI INDEPENDEN
Authors: Sugihanggit Anggraito , Noor Iswan 
Published: August 2024

The primary source of income for independent musicians (indie) namely live performances, has decreased due to the COVID-19 pandemic. Consequently, indie musicians have started to seek alternative income sources that they can rely on, such as royalties from music streaming services like Spotify and session work. This study aims to determine the significance of the influence of Spotify music streaming service, live performances, and session work on the income of independent musicians in Malang. This quantitative research utilizing primary data obtained from questionnaires, and analyzed using multiple linear regression analysis techniques. The results of the T-test with a significance level of <0.05 for X1 are 0.78; X2 is 0; X3 is 0.006. The result of the F-test is 23.01, and the result of the R2 test is 0.56. The findings of this study conclude that royalty from Spotify music streaming service does not have an impact on the income of independent musicians in Malang, while live performances and session work do have an influence on the income of independent musicians in Malang.
PENGARUH ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) DAN LINGKUNGAN KERJA TERHADAP KEPUASAN KARYAWAN
Authors: Fauziah Ayu Syifa , Arif Moh. Erfan 
Published: August 2024

Job satisfaction is the occurring or non-occurring employees’ emotional condition in response to the compensation received by the employees from their companies or organizations after comparing it with the compensation they actually wish to receive. This quantitative research was conducted to identify both partial and simultaneous effects of Organizational Citizenship Behavior (OCB) and workplace environment on the job satisfaction of interns at the Sharia Business Unit of Bank Sinarmas of Malang Branch Office during the 2021-2022 period. The sample of this research was selected using census technique for small population, so the entire population was used as the sample, resulting in 49 intern respondents. The results of the data analysis performed in SPSS 26 indicate that one Organizational Citizenship Behavior (OCB) significantly influences job satisfaction and that two workplace environment does not significantly affect the job satisfaction. Therefore, it can be concluded that Organizational Citizenship Behavior (OCB) and workplace environment simultaneously have some impacts on the dependent variable, that is job satisfaction.

Abstrak
Kepuasan kerja (job satisfaction) merupakan keadaan emosional karyawan yang terjadi maupun tidak terjadi antara nilai balas jasa kerja karyawan dan perusahaan atau organisasi dengan tingkat balas jasa kerja yang memang diinginkan oleh karyawan yang bersangkutan. Penelitian ini dilakukan untuk mengetahui pengaruh parsial dan simultan variabel Organizational Citizenship Behavior (OCB) dan Lingkungan Kerja terhadap kepuasan karyawan magang di Bank Sinarmas Unit Usaha Syariah Cabang Malang periode 2021-2022. Penelitian ini menggunakan jenis penelitian kuantitatif. Teknik pengambilan sampel menggunakan teknik sensus untuk populasi kecil, jadi seluruh populasi tersebut digunakan sebagai sampel. Ukuran sampel yang digunakan adalah sebanyak 49 orang yang diambil dari mahasiswa magang pada Perusahaan Bank Sinarmas Unit Usaha Syariah Cabang Malang. Analisis data menggunakan software SPSS 26. Berdasarkan dari hasil pengujian terhadap ketiga hipotesis dapat disimpulkan bahwa: (1) Variabel Organizational Citizenship Behavior (OCB) memiliki pengaruh yang signifikan terhadap kepuasan kerja; (2) Variabel Lingkungan kerja tidak memiliki pengaruh signifikan terhadap kepuasan kerja. Sehingga dalam penelitian ini dapat disimpulkan bahwa Variabel Organizational Citizenship Behavior (OCB) dan lingkungan kerja secara simultan memiliki pengaruh terhadap variabel dependen yaitu kepuasan kerja.
Peran Knowledge Management Dalam Meningkatkan Kualitas Layanan Pendidikan
Authors: Burhani Ahmad Zaki , Rofiaty Rofiaty 
Published: August 2024

The objective of this research is to explore to what extent knowledge management enhances the quality of an education service. This research was conducted at Thursina International Islamic Boarding School, an education institution in Malang. The data of this qualitative research was harvested from observations, library research, and interviews with two key informants, i.e., the Principal of Academic and the IT Project Leader, and three supporting informants. This research finds that the good implementation of knowledge management increases the services provided by the education institution. Knowledge management contributes to the enhancement of service quality aspects from tangibles, reliability, responsiveness, assurance, and insurance. However, the application of knowledge management in Thursina International Islamic Boarding School is still hampered by different capabilities between employees in using knowledge management facilities and by employee turnover.

Abstrak
Penelitian ini bertujuan untuk mengeksplorasi sejauh mana peran implementasi knowledge management dalam meningkatkan kualitas layanan pendidikan. Penelitian diterapkan pada suatu lembaga pendidikan yaitu Thursina Internasional Islamic Boarding School, Malang. Penelitian menggunakan pendekatan penelitian kualitatif dengan teknik pengumpulan data menggunakan wawancara, observasi dan studi dokumentasi. Narasumber kunci dalam penelitian ini adalah Principal of Academic & IT Project Leader dan tiga narasumber pendukung lainnya. Hasil penelitian menunjukkan bahwa dengan pengimplementasian knowledge management yang baik memiliki peran positif dalam meningkatkan kualitas layanan pendidikan yang diberikan. Peran tersebut berkontribusi dalam meningkatkan aspek kualitas layanan yang diberikan mulai dari bukti langsung, kehandalan, responsivitas, jaminan, dan asuransi. Selain itu, ditemukan beberapa kendala yang berpotensi untuk menghambat penerapan knowledge mangement yang ada di Thursina IIBS. Seperti kemampuan yang berbeda-beda diantara para karyawan dalam memanfaatkan fasilitas knowledge management dan kerap terjadinya turn over karyawan.
Perumusan Strategi Pada UMKM
Authors: Kyswantoro Aditya Firdaus , Prabandari Sri Palupi 
Published: August 2024

The number of batik ready-to-wear companies in Bojonegoro is increasing, ranging from micro to large-scale businesses. This increases the competition among them, and thus well-planned strategies for higher competitive advantage are key for their development. Batik Jonegoroan MAKNI is a batik ready-to-wear company focusing on Bojonegoro unique motives. Its business is still low in planning and marketing, relying mostly on word of mouth. The objective of this research is to help the company find the most suitable development strategy. To attain the goal, this qualitative descriptive case study analyzes the company’s internal and external environments based on the primary data obtained from interviews and secondary data in forms of documents, journal, and so on. The analysis using IFE-EFE matrix, SWOT matrix, and IE matrix have led to a conclusion that the most appropriate strategy for Batik Jonegoroan MAKNI is market penetration.

Abstrak
Perusahaan Konveksi batik di Bojonegoro memiliki jumlah yang semakin meningkat, baik dari usaha berskala besar maupun UMKM. Hal ini membuat persaingan yang ada menjadi semakin kompetitif. Pentingnya perencanan dan perumusan strategi yang matang merupakan kunci agar pengembangan bisnis bagi setiap usaha agar dapat memiliki keunggulan bersaing. Batik Jonegoroan MAKNI merupakan perusahaan konveksi batik yang berfokus pada batik motif ciri khas Bojonegoro. Batik Jonegoroan MAKNI menjalankan usahanya masih minim dalam perencanaan dan pemasaran yang masih mengandalkan metode mulut ke mulut (word of mouth). Penelitian ini bertujuan untuk memutuskan strategi pengembangan usaha yang tepat untuk Batik Jonegoroan MAKNI dengan melakukan identifikasi terhadap lingkungan internal dan eksternal yang ada. Jenis penelitian dalam penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif dan studi kasus. Sumber data yang digunakan berupa data primer dari wawancara, serta data sekunder berupa dokumen, jurnal, dan sebagainya. Alat analisis yang digunakan yaitu Matriks IFE-EFE, SWOT, IE. Hasil akhir dari penlitian ini menunjukan bahwa strategi yang paling tepat untuk diterapkan Batik Jonegoroan MAKNI adalah strategi penetrasi pasar.