bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of concomitant use of yokukansan on steady‐state blood concentrations of donepezil and risperidone in real‐world clinical practice
Authors: Saruwatari Junji , Kaneko Tetsuya , Murata Tsukasa , Narise Haruka , Kugimoto Sawa , Nishimura Eri , Tetsuka Natsuki , Ando Misaki , Oi Momo , Ota Masako , Hamada Nayumi , Kaneda Keiichiro , Furusho Shiro , Sakamoto Masakatsu , Kajiwara‐Morita Ayami , Oda Kazutaka , Oniki Kentaro , Ueda Keishi , Jono Hirofumi , Yasui‐Furukori Norio 
Published: July 2024

AbstractAimYokukansan is one of the most frequently used herbal medicines that can improve the behavioral and psychological symptoms of dementia. In this exploratory study, we investigated whether yokukansan affects the steady‐state blood concentrations of donepezil, risperidone, and the major metabolites of both drugs in a real‐world clinical setting.MethodsA non‐randomized, open‐label, single‐arm study examining drug–drug interactions was conducted. Fifteen dementia patients taking donepezil for at least 4 weeks and eight schizophrenia patients taking risperidone for at least 2 weeks were orally administered 2.5 g of yokukansan three times a day before or between meals, and blood samples were collected before and 8 weeks after starting co‐treatment with yokukansan. Plasma concentrations of donepezil, risperidone, and each metabolite were measured using high‐performance liquid chromatography–tandem mass spectrometry and compared before and after the 8‐week administration of yokukansan.ResultsThe plasma concentrations of donepezil and its metabolites (6‐O‐desmethyl‐donepezil, 5‐O‐desmethyl‐donepezil, and donepezil‐N‐oxide), risperidone, and its metabolite paliperidone did not differ before and after the 8‐week treatment with yokukansan.ConclusionsThe findings of this study show that the concomitant use of yokukansan may have little clinical impact on the steady‐state blood levels of donepezil and risperidone in patients with dementia or schizophrenia.
Release of ‘Kikatiti’ a multiple disease resistant pinto bean cultivar with superior productivity in Tanzania identified from evaluation of the Durango Diversity Panel
Authors: Nchimbi‐Msolla Susan , Urrea Carlos A. , Kilango Michael , Soler‐Garzón Alvaro , Porch Timothy G. , Miklas Phillip N. 
Published: July 2024

Abstract‘Kikatiti’ pinto bean (Phaseolus vulgaris L.) (Reg. no. CV‐361, PI 705149) was developed by the dry bean breeding program at the University of Nebraska, Agricultural Research Division, and submitted for release in 2021 by the Sokoine University of Agriculture in Morogoro as an upright indeterminate pinto bean with high yield potential and multiple disease resistance across bean production environments in Tanzania. Kikatiti was officially released in 2024 by the National Seed Committee. Kikatiti is an F7:8 derived line developed using the pedigree breeding method in Nebraska. The exceptional performance of Kikatiti in Tanzania was first identified by evaluation of the Durango Diversity Panel (DDP), which consisted of 200 accessions in on‐station trials conducted in Arusha and Mbeya. Kikatiti was identified as accession DDP‐094 (advanced breeding line NE2‐09‐3). Kikatiti yielded 1584 kg ha−1 across 5 years of trials in Tanzania and matured in 89 days. Kikatiti is resistant to bean rust conferred by the Ur‐3 and Ur‐11 genes, resistant to all strains of Bean common mosaic virus and Bean common mosaic necrosis virus conferred by the I and bc‐3 genes, moderately resistant to common bacterial blight conferred by the SAP6 quantitative trait locus, avoids white mold disease due to its upright architecture, and is moderately susceptible to angular leaf spot disease. Kikatiti has large seed size (35.9 g 100 seeds−1), and in on‐farm trials, farmers ranked Kikatiti above local pinto cultivars for its performance and market potential. Kikatiti has the potential to expand pinto bean production across East Africa.
Magnetized AdS/BCFT Correspondence in Horndeski Gravity
Authors: Santos Fabiano F. , Bravo‐Gaete Moisés , Ferreira Manoel M. , Casana Rodolfo 
Published: July 2024

AbstractThis work examines the thermodynamics and hydrodynamics behaviors of a five‐dimensional black hole under the influence of an external magnetic field. The solution is the gravity dual to the Anti‐de Sitter/Boundary Conformal Field Theory correspondence, enabling the study of properties within an anisotropic fluid framework. Utilizing holographic renormalization, the free energy and the holographic stress tensor residing on the boundary denoted as are computed. Within the fluid/gravity correspondence framework, authors have a class of boundary extensions in , where the stress‐energy tensor describes a magnetizing conformal fluid. The characteristics of this special solution as well as its thermodynamic properties, including the bulk and shear viscosity, the square of the speed of sound, as well as the anisotropic effects induced by the magnetic field in the magnetized conformal plasma are discussed.
Stay, leave late, leave early, return, or move onward? Interprovincial migration decisions of older adults in China, 2000–2005 and 2010–2015
Authors: Huang Cuiying , Liu Ye , Pan Zehan 
Published: July 2024

AbstractExisting studies on the migration of older adults in China have tended to treat older migration as a one‐off activity and have failed to investigate the multiple processes involved. Based on the microdata samples of the 1% national population sample surveys in 2005 and 2015, this study examines the effect of regional and personal attributes on older adults' two‐phase migration decisions. In the first phase, older adults decide whether to leave the province of household registration, while in the second phase, they decide to stay in the same province, return to the province of household registration, or move onward to a new province. In the first phase of migration, older adults' decisions were affected by several regional amenities, including medical services, public green areas, air pollution, and temperature differences. In the second phase of migration, older adults who had decided to remain in the first phase tended to leave provinces with a lower cost of living, fewer public green areas, and more extreme temperature differences. Older adults who, in the first phase, had moved to a new province with fewer medical services, more severe air pollution, and larger temperature differences were more likely to return to their province of household registration in the second phase in 2000‐2005, while those residing in provinces with more extreme temperature differences tended to move onward to a new province in 2010‐2015. This study enhances our understanding of the heterogeneity of older migration in China by disentangling the complexity of multiple migration processes.
Quadratic Speed‐ups in Quantum Kernelized Binary Classification
Authors: Lee Jungyun , Park Daniel K. 
Published: July 2024

AbstractClassification is at the core of data‐driven prediction and decision‐making, representing a fundamental task in supervised machine learning. Recently, several quantum machine learning algorithms that use quantum kernels as a measure of similarities between data have emerged to perform binary classification on datasets encoded as quantum states. The potential advantages of quantum kernels arise from the ability of quantum computers to construct kernels that are more effective than their classical counterparts in capturing patterns in data or computing kernels more efficiently. However, existing quantum kernel‐based classification algorithms do not harness the capability of having data samples in quantum superposition for additional enhancements. This work demonstrates how such capability can be leveraged in quantum kernelized binary classifiers (QKCs) through Quantum Amplitude Estimation (QAE) for quadratic speed‐up. Additionally, new quantum circuits are proposed for the QKCs in which the number of qubits is reduced by one, and the circuit depth is reduced linearly with respect to the number of sample data. The quadratic speed‐up over previous methods is verified through numerical simulations on the Iris dataset.
Treatment with low‐dose nintedanib and tacrolimus in patients with progressive fibrosing interstitial lung diseases with anti‐ARS antibody‐positive dermatomyositis
Authors: Kawaguchi Takeshi , Matsuda Motohiro , Umekita Kunihiko , Miyazaki Taiga 
Published: July 2024

AbstractNintedanib has been demonstrated to inhibit the rate of forced vital capacity decline in patients with progressive fibrosing interstitial lung diseases (PF‐ILD) at a dose of 200 or 300 mg/day in the INBUILD trial. Although concomitant use of nintedanib with P‐glycoprotein inhibitors reportedly increases the plasma concentrations of the former, tacrolimus, a P‐glycoprotein inhibitor, is often used to treat connective tissue diseases‐related interstitial lung diseases. The optimal dose of nintedanib in combination with tacrolimus for the treatment of PF‐ILD with connective tissue disease is unknown. We herein present two patients with PF‐ILD with anti‐aminoacyl‐tRNA synthetase antibody‐positive dermatomyositis who were successfully treated with low‐dose nintedanib (<200 mg/day) in combination with tacrolimus.
A rare case of a huge malignant pleural mesothelioma presenting in the posterior mediastinum
Authors: Mori Yuta , Kato Chihiro , Yamakawa Hideo , Sugiura Mariko , Fukumitsu Kensuke , Fukuda Satoshi , Kanemitsu Yoshihiro , Uemura Takehiro , Tajiri Tomoko , Ohkubo Hirotsugu , Ito Yutaka , Oguri Tetsuya , Murase Takayuki , Niimi Akio 
Published: July 2024

AbstractWe report a case of a 69‐year‐old woman with pleural mesothelioma presenting in the posterior mediastinum with a maximum diameter of 25 cm. She had a chronic cough and a pleural effusion was noted on chest X‐ray. The examination of the effusion showed high hyaluronic acid levels, and mesothelioma was suspected. A chest computed tomography scan showed a huge mediastinal mass, which caused rapid progression of respiratory failure and compression of the heart. Sufficient tissue samples could not be obtained before death. The patient died approximately 1 month after the initial visit, and a pathological autopsy was performed. The diagnosis of malignant pleural mesothelioma was made. Malignant pleural mesothelioma with a huge posterior mediastinal mass such as in this case is considerably rare; however, it is a rapidly progressing form of the disease and is reported here as an important differential diagnosis for mediastinal tumours.
Uncertainty‐aware LiDAR‐based localization for outdoor mobile robots
Authors: Park Geonhyeok , Chung Woojin 
Published: July 2024

AbstractAccurate and robust localization is essential for autonomous mobile robots. Map matching based on Light Detection and Ranging (LiDAR) sensors has been widely adopted to estimate the global location of robots. However, map‐matching performance can be degraded when the environment changes or when sufficient features are unavailable. Indiscriminately incorporating inaccurate map‐matching poses for localization can significantly decrease the reliability of pose estimation. This paper aims to develop a robust LiDAR‐based localization method based on map matching. We focus on determining appropriate weights that are computed from the uncertainty of map‐matching poses. The uncertainty of map‐matching poses is estimated by the probability distribution over the poses. We exploit the normal distribution transform map to derive the probability distribution. A factor graph is employed to combine the map‐matching pose, LiDAR‐inertial odometry, and global navigation satellite system information. Experimental verification was successfully conducted outdoors on the university campus in three different scenarios, each involving changing or dynamic environments. We compared the performance of the proposed method with three LiDAR‐based localization methods. The experimental results show that robust localization performances can be achieved even when map‐matching poses are inaccurate in various outdoor environments. The experimental video can be found at https://youtu.be/L6p8gwxn4ak.
Public enemies? The differential effects of reputation and celebrity on corporate misconduct scandalization
Authors: Han Jung‐Hoon , Pollock Timothy G. , Paruchuri Srikanth 
Published: July 2024

AbstractResearch SummaryWe explore misconduct scandalization's antecedents by focusing on the rational and emotional bases underlying reputation and celebrity, and considering how they can enhance or reduce the likelihood misconduct is scandalized as a function of the misconduct's objective and perceived severity. Specifically, we argue the quantifiable nature of objective misconduct severity enhances reputation's rational influence, but attenuates celebrity's emotion‐based appeal. Conversely, perceived misconduct severity reduces reputation's influence, while enhancing the media‐driven interest in celebrity firms' behaviors. Our findings based on corporate data breaches confirm that objective severity amplifies reputation's effect and attenuates celebrity's effect, while perceived severity amplifies celebrity's effect and attenuates reputation's effect. Our findings highlight the importance of social evaluations' sociocognitive content in understanding why only some misconduct becomes scandalized.Managerial SummaryCommitting misconduct is costly; having it scandalized is devastating. Yet little is known about how social evaluations influence why only some firms' misconduct is scandalized, beyond the vague notion that prominent firms' misconduct attracts media attention. We find that the rational and emotional bases of firms' evaluations matter. High reputation, based on the rational assessment of firms' capabilities, increases the likelihood of scandalization for objectively severe misconduct, and the influence of celebrity—originating from audiences' emotional resonance with firms' unconventional traits and behaviors—weakens as objective severity increases. Conversely, reputation's influence weakens, and celebrity's influence strengthens, as media “availability cascades” grow and increase perceived severity. In addition to providing a more realistic portrayal of media behavior, we offer insights into post‐misconduct communications and remedial actions.
Nonlinear wave propagation in homogenized strain gradient 1D and 2D lattice materials: Applications to hexagonal and triangular networks
Authors: Wazne Abdallah , Reda Hilal , Ganghoffer Jean‐François , Lakiss Hassan 
Published: July 2024

AbstractThis work aims to analyze the propagation of fully nonlinear waves, encompassing shear, extension, and bending deformation modes, within homogenized periodic nonlinear hexagonal and triangular networks, successively considering 1D and 2D situations. The wave analysis is conducted from the expression of the effective strain energy density of periodic hexagonal and triangular lattices in the nonlinear regime by a continualization of the discrete lattice equations, considering all forms of energy. We incorporate strain gradient effects into the continuous model to account for the wave‐dispersive nature. The resulting second‐gradient nonlinear continuum exhibits subsonic and supersonic propagation modes. We first examine in a 1D situation the dynamical response of the hexagonal and triangular lattices, considering varying levels of nonlinearity quantified by a single scalar valued parameter. We further evaluate the impact of a fully nonlinear analysis compared to an analysis solely based on the shear energy, regarding both supersonic and subsonic modes. The nonlinear wave propagation analysis is then extended to a 2D situation for the same two lattices. It is shown that the longitudinal mode exhibits a higher frequency at a low degree of nonlinearity; however, as the degree of nonlinearity increases, the shear mode surpasses the longitudinal mode in terms of frequency. As the wavenumber increases, the nonlinearity has a lesser impact on the frequency behavior, and the phase velocity is more influenced by other factors, such as the second gradient contributions of the effective constitutive law. Such a behavior indicates a transition from a highly nonlinear behavior at lower wave numbers to a more linear behavior at higher wave numbers.
Indonesia: How Effective Is Direct Storytelling in Enhancing Entrepreneurial Motivation for Visually Impaired People? An Experimental Study
Authors: Aldianto Leo , Anggadwita Grisna 
Published: July 2024

AbstractPeople with visual impairment have limitations in carrying out socioeconomic activities. The entrepreneurial initiative is an attempt to encourage the active participation of visually impaired people in improving their socioeconomic status. Managing motivation is essential for increasing the self-confidence and potential of people with visual impairments. Storytelling is a method that is considered capable of providing cognitive stimulation to visually impaired persons to generate entrepreneurial motivation. Thus, this study aims to identify the effectiveness of the storytelling method in increasing the entrepreneurial motivation of visually impaired people. This study used a quasi-experimental design by comparing treatment and control groups. Statistical analysis was performed to test the results of the pre- and post-tests. This study was conducted at a social institution in Indonesia for the visually impaired. The results of this study show that direct storytelling is an effective method for increasing entrepreneurial motivation in people with visual impairments. Statistical tests showed a difference between the experimental and control groups after the storytelling intervention, significantly increasing entrepreneurial motivation. This study provides new insights into entrepreneurship by using a storytelling method. This study also presents policy implications for developing empowerment models for persons with disabilities, particularly the entrepreneurial approach for visually impaired people.
Calculation and Selection of Motor Parameters in Automation System
Authors: Yao Fulai , Yao Yaming 
Published: July 2024

AbstractMotors are the most important executive components in electrical automation equipment, including AC motors, DC motors, AC servo motors, DC servo motors, stepping motors, etc. In the design of the automation system, the selection of the motor is a frequently encountered problem. You need to calculate the parameters of the required motor. Novices often do not know where to start. Below we give a simple calculation and selection method.
Efficiency Optimization of Power Stations with Different Generating Units
Authors: Yao Fulai , Yao Yaming 
Published: July 2024

AbstractThere are many power stations in the world with different generators. These include thermal power stations, hydropower stations, etc. They convert the energy of raw materials into electrical energy. In these power stations, with the same input of raw materials, there is maximum power generation. To achieve the maximum, we should decide how many generators to use and how many tasks should be assigned to each generator.
Classical Kerr-Schild double copy in bigravity for maximally symmetric spacetimes
Authors: García-Compeán H. , Ramos C. 
Published: July 2024

Abstract
A generalized Kerr-Schild ansatz for bigravity, already considered in the literature, which leads to linear interactions between the metrics is used to study the bigravity equations in the context of the double copy. By contracting the resulting spin-2 field bigravity equations of motion using Killing vector fields, as is usually carried out in general relativity, we arrive to the single and zeroth copy equations for the mentioned ansatz. For the case of stationary solutions, we obtain two Maxwell and two conformally coupled scalar field equations for the single and zeroth copies respectively, and the linear interactions are absent. In the time-dependent case we obtain equations for the fields which are coupled. By decoupling these equations and at the zeroth copy level, we recover a massless and a massive field whose mass is proportional to the Fierz-Pauli mass and depends on the coefficients of the interaction potential between the metrics. This has been also previously documented in the literature and is now reinterpreted within the context of the double copy proposal.
Rechtsprechung zu toxikologischen Schwellenwerten
Authors: Sproll Constanze , Walch Stephan G. , Lachenmeier Dirk W. 
Published: July 2024

ZusammenfassungToxikologische Schwellenwerte wie die duldbare tägliche Aufnahmemenge (Acceptable Daily Intake, ADI), die akute Referenzdosis (ARfD) und die niedrigste Dosis mit beobachteter schädlicher Wirkung (Lowest Observed Adverse Effect Level, LOAEL) sind entscheidend für die Bewertung der Sicherheit von Lebensmitteln. Sie berücksichtigen potenzielle Risiken durch Kurz- und Langzeitexposition gegenüber bestimmten Inhaltsstoffen und Kontaminanten in Lebensmitteln. Dieser Artikel erläutert die Bedeutung und Verwendung dieser Schwellenwerte im Sachverständigengutachten und deren aktuelle Beurteilung in der Rechtsprechung, die zwischen Verbraucherinteressen und wirtschaftlichen Interessen von Lebensmittelbetrieben abwägen muss.
Semi-classical Pseudo-differential Operators on $$\hbar \mathbb {Z}^n$$ and Applications
Authors: Botchway Linda N. A. , Chatzakou Marianna , Ruzhansky Michael 
Published: July 2024

AbstractIn this paper we consider the semiclassical version of pseudo-differential operators on the lattice space $$\hbar {{\mathbb {Z}}^{n}}$$

ħ

Z

n

. The current work is an extension of the previous work (Botchway et al. in J Funct Anal 278(11):108473, 33, 2020) and agrees with it in the limit of the parameter $$\hbar \rightarrow 1$$

ħ
→
1

. The various representations of the operators will be studied as well as the composition, transpose, adjoint and the link between ellipticity and parametrix of operators. We also give the conditions for the $$\ell ^p$$

ℓ
p

, weighted $$\ell ^2$$

ℓ
2

boundedness and $$\ell ^p$$

ℓ
p

compactness of operators. We investigate the relation between the classical and semi-classical quantization in the spirit of Ruzhansky and Turunen (Pseudo-differential operators and symmetries. Pseudo-differential operators, vol 2. Theory and Applications, Birkhäuser, Basel, 2010; J Fourier Anal Appl 16(6):943–982, 2010) RTspsJFAA and employ its applications to Schatten–von Neumann classes on $$\ell ^2( \hbar \mathbb {Z}^n)$$

ℓ
2

(
ħ

Z

n

)

. We establish Gårding and sharp Gårding inequalities, with an application to the well-posedness of parabolic equations on the lattice $$\hbar \mathbb {Z}^n$$

ħ

Z

n

. Finally we verify that in the limiting case where $$\hbar \rightarrow 0$$

ħ
→
0

the semi-classical calculus of pseudo-differential operators recovers the classical Euclidean calculus, but with a twist.