bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sosialisasi Dan Edukasi Qr Code Indonesia Standard (QRIS) Sebagai Aplikasi Pembayaran Non Tunai Pada Generasi Milenial
Authors: Siregar Zainal Arifin , Yolanda Cindy , Natalia Butarbutar Chintya Winda , Iqbal Chaira Teuku Muhammad , Prayogi Oki , Tanjung Oppie Meisya 
Published: August 2024

kegiatan barter hingga transaksi secara digital, di Indonesia transaksi nontunai yang berbasis dgital selalu mengalami peningkatan dari tahun ketahun. Bank Indonesia menerbitkan standar QR Code untuk pembayaran transaksi berbasis digital yaitu Quik Response Code Indoneian Standart (QRIS) yang merupakan uang elektonik dalam bentuk dompet digital, server, maupun banking mobile. Standardisasi QR Qode berfungsi untuk mempercepat proses transaksi keuangan serta mudah dan aman karena transkasi digital diawasi oleh regulator dengan melalui satu pintu. Generasi milenial (mahasiswa) merupakan salah satu sasaran dari aplikasi QRIS yang mendominasi pada penggunaanya, sehingga program edukasi pada generasi milenial khususnya mahasiswa tentang QRIS sebagai alat transaksi yang mana hasil yang akan diproleh adalah pemahaman serta perluasan penggunaan QRIS sebagai alat transaksi nontunai di lingkungan Fakultas Bisnis dan Humaniora dan lingkungan sekitar serta diharapkan mahasiswa mampu menyampaikan kepada masyarakat terkait dengan penggunaan aplikasi ini.
Penyuluhan Penggunaan Obat Antibiotika Yang Tepat Pada Ibu PKK Di Desa Sunggal
Authors: Tambunan Ika Julianti , Febriani Yessi , Nadia Syarifah , Margatha Linda , Sihotang Supran Hidayat , Putri Nurul Maulida , Pratiwi Nur Hanifa , Firdaus Tya Novita 
Published: August 2024

Pengobatan sendiri dengan antibiotik sering dipengaruhi oleh faktor kesehatan sosio-kultural dan terkadang terkait dengan penyerahan antibiotik tanpa resep serta praktik peresepan yang kurang baik. Masyarakat memiliki peran penting dalam mencegah dan mengendalikan penyebaran resistensi antibiotik. Tingginya penyalahgunaan antibiotik di masyarakat disebabkan oleh rendahnya pengetahuan tentang penggunaan yang tepat. Tujuan dari pengabdian ini adalah menyebarkan pemahaman kepada masyarakat mengenai penggunaan antibiotik yang benar untuk mencegah terjadinya resistensi antibiotik. Metode pengabdian ini melibatkan pendekatan deskriptif dengan menggunakan kuisioner pre-test dan post-test untuk menganalisis pemahaman masyarakat sebelum dan setelah pemaparan materi. Pengabdian ini, dihadiri 25 partisipan yang terdiri dari ketua dan anggota PKK Desa Sunggal, Dosen dan mahasiswa Fakultas Farmasi Universitas Tjut Nyak Dhien. Harapannya pengabdian ini dapat memberikan pengetahuan tentang cara yang tepat dalam menggunakan antibiotik untuk menghindari resistensi yang dapat berdampak pada Kesehatan dan perekonomian.
Pengaruh Bauran Pemasaran Terhadap Keputusan Pembelian Di UD.Bless Optical Kawiley
Authors: Kenanga Dhian Theresia 
Published: August 2024

Dalam penelitian ini menggunakan jenis penelitian deskriptif kuantitatif dengan menggunakan metode survey dengan tujuan untuk membahas pengaruh bauran pemasaran terhadap keputusan konsumen di UD. Bless Optical Kawiley. Adapun teknik analisis menggunakan uji normalitas, uji validasi, uji reabilitasi, uji linearitas, regresi linear sederhana, dan koefisien determinasi dengan menggunakan bantuan aplikasi IBM SPPS Statistics 26. Populasi penelitian ini adalah 176 orang yang telah melakukan pembelian di UD. Bless Optical Kawiley. Pengambilan sampel dilakukan menggunakan teknik simple random sampling. Sampel dalam penelitian ini diambil sebanyak 64 responden,dengan pertimbangan bahwa jumlah tersebut dapat mewakili sebagai sampel penelitian. Hasil penelitian menunjukkan bahwa nilai dari 0,490 < 0,246 dan nilai signya 0,000 kurang dari 0,05 yang artinya bahwa bauran pemasaran berpengaruhi positif dan signifikan terhadap keputusan pembelian.
Pemberian Minyak Zaitun Terhadap Masalah Integritas Kulit Anak Thalasemia Di Rsud Arifin Achmad Pekanbaru
Authors: Sudiarti Putri Eka , Akhlakul Qorimah Wanda , Shofiyani  , Hotna Siagian Siti 
Published: August 2024

Salah satu pemberian non farmakologi untuk mengatasi masalah integritas kulit yaitu pemberian minyak zaitun. Karya Ilmiah Akhir Ners ini bertujuan untuk mengetahui asuhan keperawatan pada An.H dengan pemberian minyak zaitun terhadap masalah integritas kulit di ruangan Thalassemia RSUD Arifin Achmad Pekanbaru. Hasil penelitian saat pengkajian didapatkan klien tampak pucat, kulit tampak kering dan bersisik, maka diagnosa keperawatan yang muncul yaitu gangguan integritas kulit. Intervensi dilakukan yaitu pemberian minyak zaitun untuk mengatasi masalah integritas kulit, implementasi dilakukan selama 3x pemberian yaitu pada 21 s/d 22 februari 2 hari secara berturut-turut dan 1 hari setelah 1 bulan pada tanggal 15 Maret 2023 dengan waktu selama ±5-10 menit setiap pertemuan. Hasil evaluasi penelitian didapatkan terjadi perubahan pada masalah integritas kulit sebelumnya kulit tampak kering, bersisik setelah diberikan minyak zaitun menjadi kulit masih tampak kering tapi tidak bersisik. Diharapkan keluarga dapat saling bekerja sama dalam merawat, membantu klien untuk selalu dapat memperhatikan kesehatannya, mendukung agar selalu melakukan pemberian minyak zaitun dengan rutin setiap hari agar masalah integritas kulit terjaga dengan baik.
Multiple Misaligned Outflows and Warped Accretion Flows in the Proto-multiple System Per-emb-8 and 55
Authors: Lin Shang-Jing , Yen Hsi-Wei , Lai Shih-Ping 
Published: August 2024

Abstract
To investigate the formation process of multiple systems, we have analyzed the Atacama Large Millimeter/submillimeter Array archival data of the 1.3 mm continuum, 12CO (2-1) and C18O (2-1) emission in a proto-multiple system consisting of a Class 0 protostar Per-emb-8 and a Class I protobinary Per-emb-55 A and B. The 1.3 mm continuum emission is likely to primarily trace their protostellar disks, and the Keplerian disk rotation is observed in Per-emb-8 and Per-emb-55 A in the emission lines. In Per-emb-8, we identify two arm-like structures with a length of ∼1000 au connecting the eastern and western of its disk in the continuum and C18O emission. Our analysis suggests that these arm-like structures are most likely infalling flows. In the 12CO emission, we discover a second bipolar outflow associated with Per-emb-8. The two bipolar outflows in Per-emb-8 are possibly launched along the normal axes of the misaligned inner and outer parts of its warped protostellar disk. In Per-emb-55, we find that the red- and blueshifted lobes of its bipolar outflow are misaligned by 90°. The presence of the warped disk, multiple misaligned outflows, and asymmetric infalling flows suggest complex dynamics in proto-multiple systems, and these could be related to the tidal interactions between the companions and/or the turbulent environments forming this proto-multiple system.
Dead or Alive? How Bursty Star Formation and Patchy Dust Can Cause Temporary Quiescence in High-redshift Galaxies
Authors: Faisst Andreas L. , Morishita Takahiro 
Published: August 2024

Abstract
The recent discovery of a galaxy at z = 7.3 with undetected optical emission lines and a blue UV-to-optical continuum ratio in JWST spectroscopy is surprising and needs to be explained physically. Here, we explore two possibilities that could cause such a seemingly quiescent ∼5 × 108
M
⊙ galaxy in the early Universe: (i) stochastic variations in the star formation history (SFH) and (ii) the effect of spatially varying dust attenuation on the measured line and continuum emission properties. Both scenarios can play out at the same time to amplify the effect. A stochastic star formation model (similar to realistic SFHs from hydrodynamical simulations of similar-mass galaxies) can create such observed properties if star formation is fast-varying with a correlation time of <150 Myr given a reasonable burst amplitude of ∼0.6 dex. The total time spent in this state is less than 20 Myr, and the likelihood of such a state to occur over 500 Myr at z = 7 is ∼50% (consistent with current observations). On the other hand, we show that a spectrum with blue UV continuum and lack of emission lines can be reproduced by a blue+red composite spectrum. The UV continuum is emitted from dust-free density-bounded H ii regions (blue component), while the red component is a dust-obscured starburst with weakened emission lines due to strong differential dust attenuation between stellar and nebular emission. Future resolving far-infrared observations with the Atacama Large Millimeter/submillimeter Array will shed light on the latter scenario.
Spectra of GRB 221009A at Low Energies Derived from Ground-based Very Low-frequency Measurements
Authors: Cheng Wen , Xu Wei , Xiong Shaolin , Gu Xudong , Ni Binbin , Wang Chenwei , Zhang Yanqiu , Wang Shiwei , Feng Jingyuan , Pan Yudi , Xu Haotian , Ma Wenchen 
Published: August 2024

Abstract
The gamma-ray burst (GRB) event GRB 221009A was the brightest event that has ever been detected to date. Owing to its unexpected brightness, the temporal and/or spectral information of the prompt emission cannot be accurately measured by many satellites (with the only exception of GECAM-C), since they suffered from significant pulse pileup and data saturation effects. Similarly, the X45 solar flare event occurring on 2003 November 4 saturated space-borne X-ray detectors, and it was through ground-based measurements of very low-frequency (VLF) signals that the magnitude of this event was determined, since VLF signals are particularly sensitive to the disturbance on the D-region ionosphere caused by low-energy photons. Therefore, in this study, we first report measurements of VLF signals from the JJI and VTX transmitter as recorded in Shiyan, China, when GRB 221009A occurred. The amplitude change was ∼1.25 and ∼2.31 dB for the JJI and VTX transmitter, respectively. Using a suite of well-validated models, we have further simulated the influence on the D-region ionosphere induced by low-energy photons (<100 keV) of GRB 221009A. Compared with the pre-GRB condition, the electron density was enhanced by 39.75% and 626.61% at 60 and 70 km altitude for the VTX-SYS path and 39.73% and 621.11% at 60 and 70 km altitude for the JJI-SYS path, respectively, with the altitude of notable electron density change being as low as ∼30 km. Moreover, we have compared modeling results of VLF signal change with our measurements during GRB 221009A. The good agreements obtained in terms of amplitude change and overall trend validate the fluxes and spectra of GRB 221009A at low energies (<20 keV) as measured by GECAM-C.
On the Magnetic Braking Law in Black Hole Low-mass X-Ray Binaries
Authors: Deng Zhu-Ling , Li Xiang-Dong 
Published: August 2024

Abstract
Magnetic braking (MB) plays an important role in the evolution of close low-mass X-ray binaries (LMXBs). It is also essential to the formation of ultracompact X-ray binaries (UCXBs). There have been lively investigations on the MB mechanism(s) in both single stars and close binaries including cataclysmic variables and neutron star (NS) LMXBs but with diverse conclusions. In this paper we explore the effect of MB on the black hole (BH) LMXB evolution. We combine binary population synthesis with detailed binary evolution to obtain the expected properties of the Galactic BH LMXB population. The simulated results are compared with the observational data including the BH mass, companion mass, companion temperature, orbital period, and mean accretion rate. Our results reveal that the MB laws with relatively low efficiency (i.e., RM12 and RVJ83) exhibit better agreement with observations, contrary to what was found for NS LMXBs. This raises the interesting question about whether MB really follows the same unified law in different types of binaries. We also predict that only a very small fraction (≲2.5%) of BH LMXBs can evolve to be UCXBs. This explains why no BH UCXB has been discovered so far.
Retinoblastoma and Its Masquerades
Authors: Ibrahim Moustafa W. , Hassanein Dina H. , Salah Shaymaa H. , Swaify Islam Y. 
Published: August 2024

Abstract
Retinoblastoma is the most common malignant intraocular tumor in childhood and accounts for 3% of all childhood cancers, with an incidence of approximately 1 in 17,000 live births, and approximately 8000 new cases are diagnosed each year worldwide. Despite the great advances in retinoblastoma management modalities, with survival rates reaching up to 95%–98% in developed countries, early diagnosis still represents a challenge in developing countries, resulting in a longer lag time in diagnosis and lower survival rates. This review article aims to highlight the various retinoblastoma presentations and shed light on possible retinoblastoma mimickers. Accurate differentiation between retinoblastoma and conditions that mimic retinoblastoma is crucial for proper management, and a high index of suspicion is therefore necessary for a proper and prompt diagnosis of retinoblastoma cases, which is the key to decreasing morbidity and mortality.
Recent advances in cardiology – Hot trials from the American Heart Association Annual Scientific Meeting 2023
Authors: Pradhan Akshyaya , Prajapati Sudesh , Vishwakarma Pravesh 
Published: August 2024

ABSTRACT
Cardiovascular (CV) diseases are the leading causes of death worldwide in both sexes alike. However, there have been significant developments in CV pharmacotherapy, percutaneous intervention, and systems of care over the past three decades in parallel. Several landmark studies were presented and discussed in American Heart Association (AHA) 2023 Scientific Sessions held in Philadelphia. The dapagliflozin-myocardial infarction (MI) and SELECT discussed the CV benefits of newer antidiabetic drugs. The AZALEA-TIMI and ARTESIA evaluated newer anticoagulants in atrial fibrillation. VERVE-101 and LEPODISIRAN studies were related to lipid-lowering in clinical practice. The ESPRIT trial demonstrated the benefits of intensive blood lowering, while KARDIA-1 tested a new RNA-based therapeutic agent for blood pressure lowering. The MINT trial evaluated strategies for blood transfusion in anemia concomitant with acute MI. ORBITA-2 study demonstrated the positive impact of percutaneous coronary intervention for angina control in stable coronary artery disease. Hence, these studies encompassed almost all aspects of cardiology, including heart failure, acute coronary syndrome, lipidology, anticoagulation, hypertension, obesity, and coronary intervention.
Neuroprotective Effects of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors (Gliflozins) on Diabetes-Induced Neurodegeneration and Neurotoxicity: A Graphical Review
Authors: Gholami Mina , Coleman-Fuller Natalie , Salehirad Mahsa , Darbeheshti Sepideh , Motaghinejad Majid 
Published: August 2024

AbstractDiabetes is a chronic endocrine disorder that negatively affects various body systems, including the nervous system. Diabetes can cause or exacerbate various neurological disorders, and diabetes-induced neurodegeneration can involve several mechanisms such as mitochondrial dysfunction, activation of oxidative stress, neuronal inflammation, and cell death. In recent years, the management of diabetes-induced neurodegeneration has relied on several types of drugs, including sodium-glucose cotransporter-2(SGLT2) inhibitors, also called gliflozins. In addition to exerting powerful effects in reducing blood glucose, gliflozins have strong anti-neuro-inflammatory characteristics that function by inhibiting oxidative stress and cell death in the nervous system in diabetic subjects. This review presents the molecular pathways involved in diabetes-induced neurodegeneration and evaluates the clinical and laboratory studies investigating the neuroprotective effects of gliflozins against diabetes-induced neurodegeneration, with discussion about the contributing roles of diverse molecular pathways, such as mitochondrial dysfunction, oxidative stress, neuro-inflammation, and cell death. Several databases—including Web of Science, Scopus, PubMed, Google Scholar, and various publishers, such as Springer, Wiley, and Elsevier—were searched for keywords regarding the neuroprotective effects of gliflozins against diabetes-triggered neurodegenerative events. Additionally, anti-neuro-inflammatory, anti-oxidative stress, and anti-cell death keywords were applied to evaluate potential neuronal protection mechanisms of gliflozins in diabetes subjects. The search period considered valid peer-reviewed studies published from January 2000 to July 2023. The current body of literature suggests that gliflozins can exert neuroprotective effects against diabetes-induced neurodegenerative events and neuronal dysfunction, and these effects are mediated via activation of mitochondrial function and prevention of cell death processes, oxidative stress, and inflammation in neurons affected by diabetes. Gliflozins can confer neuroprotective properties in diabetes-triggered neurodegeneration, and these effects are mediated by inhibiting oxidative stress, inflammation, and cell death.
Laparoscopic totally extraperitoneal management of giant inguinoscrotal hernia with loss of domain
Authors: Cumar Bharath , Christopher Pradeep Joshua , Kumar S. Saravana , Natarajan Ramesh , Ramakrishnan Parthasarathi , Chinnusamy Palanivelu 
Published: August 2024

Abstract
A giant inguinoscrotal hernia extends below the level of the midpoint of the thigh, in an upright position. They are usually due to the neglect of the patient and fear of surgical intervention. Patients typically present with lower urinary tract symptoms, ulcers over the scrotum caused due to dribbling of urine and rarely with obstruction or strangulation. Here, we present a similar case of an uncomplicated giant inguinoscrotal hernia with a Tanaka index of 74% who was preoperatively optimised with BOTOX (BOtulinum TOXin-A) and pre-operative progressive pneumoperitoneum and was managed laparoscopically with enhanced totally extraperitoneal repair. This signifies the importance of optimisation of the patients, especially with loss of domain help in managing such cases without any resection of bowel or omentum. Moreover, this proper pre-operative optimisation also helped us in managing such a case laparoscopically.
Ultrasound Guided Internal Jugular Vein Acesss: Comparison Between Short Axis And Long Axis Technique
Authors: Gotur Udaykumar , Taneja Sameer 
Published: August 2024

Abstract

Background:
Percutaneous techniques have transformed vascular cannulation. It has reduced the need for open procedures and the associatedwoundcomplications, but percutaneous techniques have made physicians dependent on relationships between surface anatomic landmarks and deep anatomic structures. Now, percutaneous central venous catheter insertion by physicians has a lesser complication rate. During central venous catheterization, the complications include infection, occlusion, thrombosis and mechanical complications.

Aims and Objective:
To relate the inner course of cannulating needle, familiarity of surface anatomic landmarks excludes the complication. Deep anatomic relationships visualization does not only improves the efficacy and safety of the procedure but also supplements the operator’s ability to identify difficult cannulations. The safety of internal jugular cannulations increases with ultrasound visualization. Central venous cathetrization (CVC) is done for hemodynamic monitoring (such as central venous pressure) long-term administration of fluids, antibiotics, total parental nutrition, and hemodialysis.

Material and Methods:
Most commonly, the internal jugular vein (IJV) is cannulated because of its relatively less complications and easy accessibility. Seldinger technique is used for IJV cannulation. Landmark-guided IJV cannulation is associated with a more number of complications compared to ultrasound-guided cannulation. Ultrasound-guided cannulation improves success rate, reduces the number of needle passes, and decreases complications. Two different real-time ultrasound-guided cannulations of IJV using a short axis/out-of-plane (SA) approach and a long axis/in plane (LA) approach are compared in the study. Hence, the present study was done at our tertiary care center to compare ultrasound-guided IJV access between SA and LA technique method with the number of attempts and complications.

Results:
It was observed in the present study that 4 (10%) patients in Long axis group had posterior wall puncture while 9 (22.5%) patients in short axis group had posterior wall puncture.

Conclusion:
Posterior wall puncture incidence is lesser in long axis group than short axis group.
Thrombocytopenia in Plasmodium vivax Malaria: A Report from a Sub-zonal Hospital in Western Rajasthan
Authors: Khune Sudhir Sudhakar , Shrikanth V S , John Biju M. 
Published: August 2024

Abstract

Background:
Malaria continues to be a major public health problem in India. Vivax malaria is being increasingly seen with thrombocytopenia. The reported prevalence of the same has been extremely variable and its significance is not well established. This study was conducted to ascertain the prevalence and severity of thrombocytopenia in vivax malaria and assess the outcome of cases with severe thrombocytopenia. A secondary objective was to compare the clinical and laboratory profile of cases of vivax malaria with falciparum malaria and mixed infection.

Materials and Methods:
This hospital-based prospective study was carried out in the department of general medicine at a sub-zonal hospital in Western Rajasthan in the year 2022. Consecutive febrile patients with a diagnosis of malaria were included in the study after ruling out coexistent alternate infections.

Results:
A total of 396 cases were enrolled. Ninety-nine percent of patients were male. The mean age of the study group was 32.1 years. A total of 328 (90.8%) out of 361 vivax malaria cases had thrombocytopenia (platelet count <150 × 103 μL) with 26.5% having severe thrombocytopenia (platelet count <50 × 103 μL). The mean defervescence duration was 44.4 h in vivax malaria. 3.4% of severe vivax malaria cases required intensive care unit care due to hypotension, respiratory distress, and multiorgan dysfunction, and none of them had any bleeding manifestations. All cases recovered well after standard treatment. There was a significant statistical difference between the mean platelet count among the three types of malaria: vivax, falciparum, and mixed (vivax + falciparum infections) (P = 0.03). Similarly, on applying Chi-square test, there was a significant difference in severe thrombocytopenia across the groups (P = 0.01).

Conclusion:
There is a high prevalence of thrombocytopenia in vivax malaria including severe thrombocytopenia. In the majority of cases, this thrombocytopenia does not result in any adverse event, and cases respond well to conventional treatment. Clinicians need to be aware of the extent and severity of thrombocytopenia in vivax malaria and rule out this treatable condition in endemic areas with a high prevalence of other coexistent infections causing thrombocytopenia.
Erstlinientherapie des multiplen Myeloms: Fortschritte bei funktionellem ­Hoch­risiko und in Therapiesteuerung
Authors: Steinhardt Maximilian , Kortüm Martin , Einsele Hermann 
Published: August 2024

Das multiple Myelom (MM) ist eine maligne, durch Endorganschäden definierte Plasmazell­erkrankung, die ein wichtiges Thema bei den weltweit größten onkologischen Kongressen ASCO 2024 und EHA 2024 war. Im Vordergrund standen Vierfachkombinationen – auch bei älteren Patienten –, Studiendaten zu CAR-T-Zellen bei Erstdiagnose, MRD-gesteuerte Therapiepausen sowie neue Substanzen. Einige Präsentationen waren bereits länger mit Spannung erwartet worden, es wurden aber auch überraschende, für die Routine relevante Ergebnisse präsentiert. Die Kongresse standen insbesondere unter dem Vorzeichen der erst kürzlich als Endpunkt anerkannten MRD-Negativität als Surrogatmarker für das progressionsfreie Über­leben (PFS) beim MM.