bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic cholecystectomy in Situs inversus totalis: a case report
Authors: Alenezi Meshaal EOSS , AlJasmi Mohammad , AlRuwaished Mohammad , Ahmed Atef 
Published: August 2024

Background:
Situs inversus totalis (SIT) is a rare congenital condition characterized by the mirror-image reversal of the thoracic and abdominal organs. SIT presents significant challenges during surgical procedures that require anatomical familiarity and dexterity, such as laparoscopic cholecystectomy.

Case Presentation:
A 73-year-old woman with SIT presented with a 2-day history of left-sided hypochondrial colicky abdominal pain aggravated by food intake and associated with nausea. Physical examination revealed a positive Murphy’s sign in the left hypochondrium. Laboratory tests showed leukocytosis and elevated liver enzymes. Imaging (See Figures 1-4) confirmed acute cholecystitis with the gallbladder in the left upper quadrant. The patient was scheduled for laparoscopic cholecystectomy. Preoperative planning involved detailed imaging and coordination with the anesthesiology team. The surgical technique was adapted for SIT, including specific patient positioning and a mirror-image approach. The gallbladder was successfully removed, with careful dissection of the cystic duct and artery. Postoperative management included non-steroidal anti-inflammatory drugs, opioids, and monitoring. The patient’s recovery was uneventful, and she was discharged on the third postoperative day with follow-up instructions. The care plan included pain management, regular monitoring, early mobilization, diet progression, and scheduled outpatient visits.

Conclusion:
Laparoscopic cholecystectomy in patients with SIT requires careful preoperative planning, skilled surgical techniques, and effective team communication. Despite these challenges, successful outcomes are possible with meticulous attention to detail and adaptation to the reversed anatomy.
Anticholinergic toxidrome: a rare consequence of lupin ingestion - a case report and literature review
Authors: Alharbi Mohammed A. , Al Saeed Fatima Hatem , Alfaraj Dunya 
Published: August 2024

Background:
Lupin beans, a yellow legume seed from the Lupinus plant, are commonly used in Southern Europe, Latin America, and the Middle East. Despite their bitter taste, lupin beans are highly nutritious and rich in protein, making them popular snacks. The bitter taste is due to the presence of over 150 quinolizidine alkaloids, with Lupanine being the predominant alkaloid. If not properly debittered before ingestion, lupin toxicity and anticholinergic symptoms can occur.

Case Presentation:
A 49-year-old healthy Egyptian man presented with symptoms such as dry mouth, unsteadiness, constipation, and urinary retention for 6 hours. After investigation, it was discovered that he had consumed 400 g of bitter lupin beans within a 1-hour period, around 4-6 hours before the symptom onset. The patient was oriented, conscious, and alert, showing no signs of pain or distress. His vital signs were normal, and he had normal cardiovascular, pulmonary, gastrointestinal, and neurological examinations. His eye examination revealed fixed, dilated pupils bilaterally, blurry vision, and normal eye movement bilaterally. Laboratory tests were normal. The patient received Ringer’s lactate intravenously and was closely monitored in the emergency department. Over a 3-hour period, all symptoms and signs resolved with fluid management alone, and the patient was discharged home following his improvement.

Conclusion:
This report highlights the importance of history taking in diagnosing food-related diseases and emphasizes that physicians should consider lupin toxicity as a differential diagnosis in cases presenting with anticholinergic symptoms.
ISLAMICITY PERFORMANCE INDEX IN SHARIA COMMERCIAL BANKS IN INDONESIA & MALAYSIA
Authors: Saputri Maya Aulia , Lindrianasari  , Syaipudin Usep 
Published: August 2024

This study aims to provide empirical evidence on whether the Islamicity Performance Index affects company performance, as proxied by Return on Assets. The novelty of this research lies in proposing Third-Party Funds as an intervening variable between the influence of the Islamicity Performance Index and company performance. The sample for this study includes 8 Islamic commercial banks in Indonesia and 10 Islamic commercial banks in Malaysia, selected using purposive sampling and secondary data collection methods. The analytical methods used in this study are hypothesis testing and path analysis.The study provides evidence that the Islamicity Performance Index has a positive and significant impact on Return on Assets, indicating that the Islamicity Performance Index is a relevant indicator that can affect the profitability of Islamic commercial banks in Indonesia and Malaysia. Path analysis testing concludes that third-party funds are not significant as an intervening variable between the Islamicity Performance Index and profitability in Islamic commercial banks in Indonesia and Malaysia. Another finding from the study is that firm size has a positive and significant effect on third-party funds, meaning that a larger firm size is associated with improved performance in collecting third-party funds.
Vitamin A, E, and C levels in maternal blood of patients with idiopathic preterm premature rupture of membranes, spontaneous preterm birth, and term birth
Authors: Mehndiratta Mohit , Suneja Amita , Almeida Edelbert Anthonio , Garg Seema , Kar Rajarshi , Gupta Bindiya , Kumari Rupa , Puri Dinesh 
Published: August 2024

Objectives
To compare vitamin A, E, and C levels in cases with idiopathic preterm premature rupture of membranes (pPROM), idiopathic spontaneous preterm birth with intact membrane (sPTB), and term birth (TB).

Material and Methods
There were three groups in this study: pPROM, sPTB, and TB. The sample size was 60 patients in each group (n = 60, Total = 180). Serum vitamin A and E levels and leucocyte vitamin C levels were measured using commercially available research kits.

Results
The mean (SD) vitamin A levels were 49.56 (18.66) µg/dL in the pPROM group, 48.67 (10.28) µg/dL in the sPTB group, and 52.69 (24.39) µg/dL in the TB group. The mean (SD) vitamin E levels were 19.17 (9.23) µg/dL in the pPROM group, 16.94 (10.17) µg/dL in the sPTB group, and 17.47 (11.19) µg/dL in the TB group. The mean (SD) vitamin C levels were 47.89 (9.53) µM in the pPROM group, 45.78 (7.92) µM in the sPTB group, and 42.35 (6.14) µM in the TB group. Vitamin C levels were significantly higher in mothers who developed pPROM (p<0.05) when compared with TB and tended toward significance in mothers who developed sPTB compared with TB.

Conclusion
Vitamin A and E levels were comparable in all three groups. Higher leucocyte vitamin C levels, observed in patients with pPROM (vsTB) and sPTB (vsTB), were not able to protect against pPROM and sPTB. Thus, supplementation of these vitamins during pregnancy is questionable and needs further exploration.
PENERAPAN KURIKULUM MERDEKA YANG DITINJAU DARI POTENSI STEAM PADA MATERI EKOSISTEM DI SMA PGRI 2 KAYEN PATI
Authors: Rohmah Siti , Roshayanti Fenny 
Published: August 2024

Kurikulum merdeka merupakan kurikulum dengan pembelajaran intrakulikuler yang beragam dimana konten akan lebih optimal agar peserta didik memiliki cukup waktu untuk mendalami konsep dan menguatkan kompetensi. Penerapan kurikulum merdeka dapat didukung dengan pendekatan STEAM untuk mempermudah pemahaman peserta didik secara menyeluruh. Tujuan penelitian ini adalah untuk mendeskripsikan profil penerapan kurikulum merdeka yang ditinjau dari potensi STEAM pada materi ekosistem kelas X di SMA PGRI 2 Kayen Pati. Jenis penelitian ini merupakan penelitian deskriptif kualitatif. Sumber data yang digunakan dalam penelitian ini adalah siswa kelas X9 dan X11 serta guru biologi yang mengajar di kelas X9 dan X11. Pengambilan sampling dengan teknik Pusposive Sampling. Instrumen yang digunakan dalam penelitian adalah lembar observasi, lembar wawancara, angket dan dokumentasi. Metode analisis data yang digunakan adalah metode yang dikemukakan oleh Miles Huberman dan teknik keabsahan data menggunakan triangulasi data. Hasil penelitian ini menunjukkan bahwa sekolah SMA PGRI 2 Kayen Pati telah menerapkan kurikulum merdeka berbasis pendekatan STEAM pada pembelajaran biologi materi ekosistem.
Kegiatan Edukasi Tahapan Pemberian Makanan Pendamping ASI Sebagai Upaya Penerapan Penyuluhan Kesehatan Rumah Sakit di Luar Gedung
Authors: Prasetyorini Anif , Ramhawati Indri , Shandy Rafifah Nur , Ananta Novian Saga , Cahyaningrum Rina , Nafa R Tria , Rahmawati Indah 
Published: August 2024

Indonesian Nutritional Status Survey (SSGI), the prevalence of stunting has increased, partly due to less than optimal visits by toddlers to posyandu for measurements and weighing. Empowerment is the initial milestone in Hospital Health Promotion activities which can be implemented outside the building. The objectives to empower through education about the stages of giving complemengtary breast milk to mothers of toddlers. The Methods: outreach to the community around the hospital by providing pre-tests and post-tests to measure knowledge. The Results showed two approaches were used to carry out the activity: evaluation and presentation. The presentation and question-and-answer period is the first step. Four activities make up the presentation: the opening, introduction, implementation, and conclusion. The aim and objectives of the exercise are explained as part of the introductory activity. The explanation of the planned activities completes the introductory phase. Implementation efforts include giving participants information on what is meant by "complementary foods for breast milk," the advantages of MP ASI, the different kinds of main foods, and the different kinds of snacks. explanations of age groups, child growth, MP ASI texture, MP ASI frequency, and MP ASI amount per portion, as well as things to consider when using or preparing food. The danger of giving MP ASI if is not age approriate. The second stage is the evaluation stage which shows that there is an increase in the knowledge of stage of giving MP ASI , the participant quota is fulfilled and the material is delivered to the participants. There needs to be re-empowerment of mothers of toddlers.
A case study of the assistive technology network in Sierra Leone before and after a targeted systems-level investment
Authors: Huff Stephanie , Smith Emma M , MacLachlan Malcolm 
Published: August 2024

Background Many people with disabilities in low-income settings, such as Sierra Leone, do not have access to the assistive technology (AT) they need, yet research to measure and address this issue remains limited. This paper presents a case study of the Assistive Technology 2030 (AT2030) funded Country Investment project in Sierra Leone. The research explored the nature and strength of the AT stakeholder network in Sierra Leone over the course of one year, presenting a snapshot of the network before and after a targeted systems level investment. Methods Mixed-method surveys were distributed via the Qualtrics software twice, in December 2021 and September 2022 to n=20 and n=16 participants (respectively). Qualitative data was analyzed thematically, while quantitative data was analyzed with the NodeXL software and MS Excel to generate descriptive statistics, visualizations, and specific metrics related to indegree, betweenness and closeness centrality of organizations grouped by type. Results Findings suggest the one-year intervention did stimulate change within the AT network in Sierra Leone, increasing the number of connections within the AT network and strengthening existing relationships within the network. Findings are also consistent with existing data suggesting cost is a key barrier to AT access for both organizations providing AT and people with disabilities to obtain AT. Conclusion While this paper is the first to demonstrate that a targeted investment in AT systems and policies at the national level can have a resulting impact on the nature and strength of the AT, it only measures outcomes at one-year after investment. Further longitudinal impact evaluation would be desirable. Nonetheless, the results support the potential for systemic investments which leverage inter-organizational relationships and prioritize financial accessibility of AT, as one means of contributing towards increased access to AT for all, particularly in low-income settings.
МОДЕЛЬНІ ХАРАКТЕРИСТИКИ МОРФОФУНКЦІОНАЛЬНИХ ПОКАЗНИКІВ ТА ФІЗИЧНОЇ ПІДГОТОВЛЕНОСТІ ТХЕКВОНДИСТІВ 15-17 РОКІВ
Authors: ПАШКОВА Вікторія 
Published: August 2024

В статті розкрито побудову модельних характеристик морфофункціональних показників та фізичної підготовленості тхеквондистів 15–17 років на етапі спеціалізованої базової підготовки, які є одним із важливих умов контролю та управління тренувальним процесом тхеквондистів. Мета дослідження – визначити модельні характеристики морфофункціональних особливостей та фізичної підготовленості тхеквондистів 15–17 років. Модельні характеристики тхеквондистів на етапі спеціалізованої базової підготовки 1 та 2 року навчання за більшістю показників мають тенденцію до зменшення діапазону відмінностей між ідеальним та мінімальним значенням у підготовленості спортсменів. Виявлено зменшення ідеального показника модельних характеристик стрибків на скакалці з 138,81 до 36,63, між першим роком навчання та другим, та зменшення діапазону інтервалів між ідеальним та мінімальним на 17,48 %. Дослідженням встановлено зменшення ідеального значення модельних характеристик між першим роком навчання та другим, показника вибухової сили, тесту метання тенісного м’яча на дальність, з 40,25 до 37,47 м, та мінімального – з 14,64 до 13,30. Розробка модельних характеристик тхеквондистів 15–17 років є одним із важливих умов контролю та управління тренувальним процесом тхеквондистів, це сприятиме раціональному підбору засобів та методів підготовки спортсменів з урахуванням їх індивідуальних особливостей. Проведені дослідження можуть використовуватися у моніторингу підготовленості та спортивному відборі тхеквондистів на етапі спеціалізованої базової підготовки.
Teaching Writing Skills through Descriptive Text by Using Digital Storytelling “StoryJumper”
Authors: Fitriyani Rahma , Ahsanu Muhamad , Kariadi Mustasyfa Thabib , Riyadi Slamet 
Published: August 2024

<p>The aims of this study are to describe the implementation of StoryJumper, to describe the students’ skills in writing descriptive text after being taught using StoryJumper, and to explain the teacher’s and student’s perceptions toward the use of StoryJumper at the tenth-grade of MA Al Ikhsan Beji in the Academic Year 2022/2023. This study used Classroom Action Research (CAR). The subjects of this research were students in class X Social Science 1. The data were collected from observations, tests, and interviews. The result of this research shows that teaching writing skills through descriptive text using digital storytelling “StoryJumper” run effectively. It could be seen from the result of the observation that the teacher and the students could implement StoryJumper as a medium for teaching writing descriptive text properly. The students’ skills in writing descriptive text improved after the implementation of StoryJumper. From the result of the tests, the mean scores increased from 48.95 in pre-test to 71.94 in post-test 1 and to 80.38 in post-test 2. The students’ scores were analyzed using the Paired Samples T-Test in SPSS 20. The result shows that the <em>p</em>-value is 0.000 which is less than 0.05. It means that the result is statistically significant. The teacher and students also had positive perceptions toward the use of StoryJumper. Furthermore, it can be concluded that digital storytelling “StoryJumper” is effective to be used as a learning medium for writing descriptive text.</p><p> </p><strong>Keywords</strong>: <em>Teaching Writing, Descriptive Text, Digital Storytelling StoryJumper</em>
Potensi Senyawa Salisilanilida Dari Minyak Gandapura Sebagai Antiinflamasi dan Analgetik Secara In Vivo
Authors: Adhityasmara Dhimas , Hanhadyanaputri Eka Susanti , Indriyanti Erwin 
Published: August 2024

Administration of non-steroidal anti-inflammatory drugs (NSAIDs) is the first therapeutic choice for the treatment of pain and inflammation. Several existing amide derivatives show their properties as anti-inflammatory, antidegenerative, anticancer, antimicrobial and analgesic, one of which is salicylanilide. The precursor for salicylanilide synthesis is carboxylic acid, using natural methyl salicylate from gondopuro oil and amines sonochemically with the help of Decyclocarbodiimide (DCC) coupling reagent. The research aims to carry out the synthesis of amide derivatives using DCC coupling reagent with the sonochemical method in 7 hours. Identification of synthetic compounds by spectrum elucidation using infrared spectrophotometry (FTIR-ATR), GC-MS and in-vivo anti-inflammatory and analgesic activity tests. In this study, the mixture was sonicated for 7Â hours at a temperature of Â±0oC, then left in the refrigerator overnight, evaporated at a temperature of 65oC. The precipitate formed was filtered using Buchner, washed using cold distilled water and washed again using methanol. The crystals obtained were then dried in an oven at 40ÂºC until dry, then the % yield of the synthesized compound was determined. Tests include organoleptic tests, melting point, solubility, FTIR, GC-MS In vivo anti-inflammatory and analgesic activity tests. The research results showed that salicylanilide compounds could be synthesized in 7 hours with a % yield of 27.55%. The resulting synthesis can melt from a temperature of 218-222Â°C and can dissolve in methanol, ethanol, chloroform and ether but does not dissolve in distilled water. FTIR testing on salicylanilide compounds showed the presence of phenolic -OH, aromatic C-H, C=O amide and aromatic C=C groups. The synthesized compound produced an abundance of 2.43%. The highest percentage of anti-inflammatory power was at dose 3 synthesis (7.56 mg/ 200 grams of rat body weight) at 44.46% and the highest analgesic effect was at dose 4 synthesis (10.08 mg/ 200 grams Rat BW)
Aktivitas Antiasma Nigella sativa L. Dan Amomum cardamomum Terhadap Otot Polos Bronkus, Epitel Bronkiolus, Jumlah Sel Mast, Eosinophil Mencit Asma
Authors: Firmansyah Gunawan , Widodo Gunawan Pamudji , Wijayanti Tri 
Published: August 2024

Asthma is a chronic respiratory inflammation that limits expiratory air flow. Black cumin reduces the infiltration of inflammatory cells in the respiratory tract comparable to class III antihistamines, cardamom suppresses the formation of a Th2 immune response and has the potential to be therapeutic for allergic asthma. This study aims to determine the profile of black cumin & cardamom essential oils using GC-MS, the effect of the combination of black cumin & cardamom in reducing the thickness of bronchial smooth muscle, bronchiolar epithelium, number of mast cells, and eosinophils in asthmatic mice. This research is an experimental Post-test Only Control Group Design, creating an OVA-induced asthma test animal model of 30 Balb/C mice divided into 6 normal groups (N), asthma control (N-), positive control (P+) and 3 treatment groups with dose variations (K1, K2, K3). Day 7 desensitization OVA 10Î¼g+1 mg Al(OH)3 0.5mL NaCl intraperitoneally, day 14 re-desensitization OVA 20Î¼g+2 mg Al(OH)3 1 mL NaCl. On the 21st, 23rd and 25th days, 1% OVA was inhaled. Days 26 to 39 (K1), (K2), (K3) were given a combination of black cumin oil &Â cardamom. On the 40th day, histopathology was terminated. The results of the study showed that in 3 groups of dose variations with (P+) the thickness of bronchial smooth muscle, bronchiolar epithelium, mast cells and eosinophils was significantly greater (p>0.05), meaning that there was no statistically significant difference as an anti-asthma, the combination of black cumin & cardamom was proven. reducing the thickness of bronchial smooth muscle, bronchiolar epithelium, number of mast cells and eosinophils in asthmatic mice with optimal doses of a combination of black cumin oil and cardamom oil in a ratio of 75:25 (K2) showed better antiasthmatic potential, compared to K1 (50:50) and K3 (25 :75).
The Influence of The Relay Writing Method Assisted With Audio Visual Media on Procedure Text Writing Skills in Class VII Students at SMP Negeri 35 Palembang
Authors: ST. Fianda Kirana  , Dessy Wardiah  , Muhammad Ali  
Published: August 2024

This research aims to determine the effect of the relay writing method assisted by audio-visual media on procedural text writing skills in class VII students at Palembang Public Junior School 35.. This type of research is quantitative research that uses simple linear regression testing and multiple linear regression testing to answer the hypothesis in the research. The subjects in this research were class VII.3 as an experimental class with a total of 31 students and class VII.4 as a control class with a total of 33 students. Data collection techniques in this research used documentation and test techniques. Based on the results of testing the first hypothesis, it was found that there was an influence of the application of the relay writing method on the ability to write procedural texts which received a significant value of 0.000. The results of testing the second hypothesis show that there is an influence of the use of audio-visual media on the ability to write procedural texts which gets a significant value of 0.000. The results of testing the third hypothesis prove that there is an influence of applying the relay writing method with the help of the use of audio-visual media on procedural text writing skills which obtained a significant value of 0.000.
Keywords : Estafet Writing, Audio Visual, Procedure Text.
Effect of controlled release of HGF on extracellular vesicle secretion by urine-derived stem cells
Authors: Alwan Abdelrahman , Khalil Fatma , Bowlby Joshua , Peko Gabrielle , Estrada Exel Valle , Singh Sangeeta , Deep Gagan , Zhang Yuanyuan , Farney Alan C. , Opara Emmanuel C. 
Published: August 2024

IntroductionThe hepatic growth factor (HGF) stimulates DNA synthesis and cell proliferation and plays a role in tissue protection and regeneration. In this study, we have examined the effect of incubation of HGF with urine-derived stem cells (USCs) on the secretion of small extracellular vesicles (sEV) by the cells.Materials and MethodsHGF in the incubation medium was either a bolus administration or a controlled release of an equivalent amount from microbeads within the size range of 50–200 µm made with ultrapurified low-viscosity high-guluronic acid (UP-LVG) alginate. USCs were incubated with or without HGF for 3 days or 7 days before removal of the incubation media, followed by harvesting sEV by the precipitation method. The protein content of isolated sEV was measured by bicinchoninic acid assay (BCA) for these three groups: control (no HGF beads), bolus HGF, and HGF beads. We also performed nanoparticle tracking analysis (NTA), Western blot assay, and ELISA for the HGF content of samples.ResultsWe found a significantly higher concentration of proteins in the HGF microbead group (control release group) compared to the bolus group and the control group after 7 days (p &lt; 0.0017). The NTA data aligned with the BCA; they showed a significantly higher concentration of particles within the size range of sEV (&lt;200 nm) in the group treated with HGF beads compared to the two other groups on day 7 (p &lt; 0.0001).ConclusionWe found that administration of HGF to USCs by controlled release of the growth factor significantly enhances the levels of sEV secretion during 7 days of incubation.