bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Regional Climate Change and Development of Climate Adaptation Decision Aids in the Southwestern United States
Authors: Darmenova Kremena , Apling Duane , Higgins Glenn , Hayes Philip , Kiley Heather 
Published: September 2012

AbstractOver the next 10–50 years, policy makers in the southwestern United States are faced with complex planning and policy issues associated with increasing water and energy demand as a result of warmer temperatures and reduced availability of water, compounded by continued rapid population growth and economic development. This study uses a top-down, end-to-end approach consisting of dynamical downscaling, a novel bias-correction technique, and custom-developed decision-aid tools to assess regional climate changes in the Southwest and to derive decision aids that are based on direct communication with the planners at four military installations in the region. Dynamical downscaling is performed with the Weather Research and Forecasting model driven by the National Centers for Environmental Prediction reanalysis and the Max Planck Institute for Meteorology’s ECHAM5 general circulation model for two time periods: current (2000s) and future (2030s). A unique two-stage bias correction is developed to adjust current and future hourly temperature and precipitation to be consistent with historical reference data. The authors’ assessment of regional climate change, which is based on downscaled bias-corrected fields, points to a dryer and warmer future climate in the Southwest. The energy-usage modeling produced a statistically significant increase in natural gas consumption and a possible decrease in electricity usage in two military installations in Colorado, which is a direct consequence of decrease/increase in heating/cooling degree-days resulting from warmer temperatures in the future. In addition, the results indicate an increasing number of oppressive heat days in the future, which may impact long-term planning practices with respect to heat-stress control and heat-casualty management.
The Effect of Intra-articular Injection of MicroRNA-210 on Ligament Healing in a Rat Model
Authors: Shoji Takeshi , Nakasa Tomoyuki , Yamasaki Keiichiro , Kodama Akira , Miyaki Shigeru , Niimoto Takuya , Okuhara Atsushi , Kamei Naosuke , Adachi Nobuo , Ochi Mitsuo 
Published: September 2012

Background: It is known from clinical and experimental studies that the healing potential of the anterior cruciate ligament (ACL) is extremely poor and that early phases of ligament healing require an augmented blood supply. MicroRNA (miRNA) is a type of small, noncoding RNA that negatively regulates gene expression, and miRNA (miR)-210 is reported to be crucial for cell response to hypoxia, vascular endothelial growth factor (VEGF)–driven endothelial cell migration, and formation of capillary-like structures. Purpose: The purpose of this study was to examine the effect of intra-articular injection of miRNA miR-210 on acceleration of ACL healing. Study Design: Controlled laboratory study. Methods: Two experiments were performed in this study. The ACLs of 12-week-old male LEW/CrlCrlj rats were partially transected. First, the temporal expression change of miR-210 after ACL injury was analyzed using real-time polymerase chain reaction (PCR) on day zero, and 1, 2, and 4 weeks after injury (n = 5 at each time point). Next, intra-articular injection of double-stranded (ds) miR-210 with atelocollagen was performed soon after injury. The control group was injected with control small interfering RNA (siRNA). Four weeks after injection, biomechanical and histological assessments of samples stained with H&E as well as Masson trichrome, and immunohistochemistry for VEGF, fibroblast growth factor 2 (FGF2), isolectin B4, and collagen type I, were performed. Real-time PCR analysis was also performed for quantitative evaluation of miR-210, VEGF-A, and collagen type I. Results: Real-time PCR analysis revealed that miR-210 expression was decreased soon after injury but gradually increased thereafter. Histological analysis confirmed that the transected area was covered with healing tissue in the miR-210 group but remained devoid of any tissue in the control group 4 weeks after injury. Biomechanical analysis confirmed the improvement of biomechanical properties in the miR-210 group; the ultimate failure loads 4 weeks after injection were 30.5 ± 3.1 N in the miR-210 group and 22.8 ± 3.1 N in the control group ( P < .05). Real-time PCR analysis showed that endogenous miR-210, VEGF, and collagen type I were highly expressed compared with controls, and immunohistochemistry for VEGF, FGF2, isolectin B4, and collagen type I showed that VEGF and FGF2 were highly upregulated, and there were abundant blood vessels and fibrotic deposition in the miR-210 group. Conclusion: Injection of ds miR-210 was effective in promoting the healing of partially torn ACLs through enhancement of angiogenesis via upregulation of VEGF and FGF2. Clinical Relevance: It might represent a potential therapeutic approach for treatment of ACL injury.
Capitalist Class Agency and the New Deal Order
Authors: McIntyre Richard , Hillard Michael 
Published: September 2012

In the United States the apparent crisis of neoliberalism has called forth nostalgia for the regulated capitalism of the post World War II era. In particular, radical economists’ thinking continues to be influenced by the notion of a “limited postwar capital-labor accord.” But a careful accounting of historial scholarship since the 1980s shows the stylized thinking found in social structures of accumulation (SSA) literature and radical political economy generally to be inaccurate and misleading: inaccurate because it creates an image of a golden age that never was, and misleading in that it suggests a politics of social cooperation rather than worker militancy. In this paper we show that capitalists as a class never accepted anything resembling such an accord. JEL classification: B5, J5, N32
To enforce or not to enforce? The use of collaborative interfaces to promote social skills in children with high functioning autism spectrum disorder
Authors: Ben-Sasson Ayelet , Lamash Liron , Gal Eynat 
Published: September 2012

The goal of this stud was to examine whether a technological touch activated Collaborative Puzzle Game (CPG) increased positive social behaviors in children with high functioning autism spectrum disorder (HFASD). The CPG involved construction of a virtual puzzle by selecting and dragging pieces into the solution area on a touch screen table. The target picture was presented on the top of the screen. Six dyads of children with HFASD (aged 8-11 years) engaged in the CPG in a Free Play (FP) mode in which partners could independently move puzzle pieces versus in an Enforced Collaboration (EC) mode in which partners could only move puzzle pieces together. Videos of the dames were coded for the frequencies of positive and negative social interaction, affect, play, and autistic behaviors. Parents completed the Social Responsiveness Scale (SRS). Wilcoxon Signed-ranks tests indicated that children with HFASD showed significantly higher frequencies of positive social interaction and collaborative play in the EC versus FP modes but there were no differences in negative social behaviors. Differences in social behaviors between partners during the puzzle games were not significant; however there were differences within pair in the severity of social deficits as assessed by the SRS questionnaire. The CPG in an EC mode was effective in promoting positive social interaction by requiring children to work together towards a mutual goal. However, the increased challenge in this mode, particularly for children with lower social-communication skills, suggests the need for establishing selection criteria and mediation steps for such interventions.
Atherosclerotic renal artery stenosis is prevalent in cardiorenal patients but not associated with left ventricular function and myocardial fibrosis as assessed by cardiac magnetic resonance imaging
Authors: Emans Mireille E , van der Putten Karien , Velthuis Birgitta K , de Vries Jan JJ , Cramer Maarten J , America Yves GCJ , Hillege Hans L , Meiss Louis , Doevendans Pieter AFM , Braam Branko , Gaillard Carlo AJM 
Published: September 2012

Abstract

Background
Atherosclerotic renal artery stenosis (ARAS) is common in cardiovascular diseases and associated with hypertension, renal dysfunction and/or heart failure. There is a paucity of data about the prevalence and the role of ARAS in the pathophysiology of combined chronic heart failure (CHF) and chronic kidney disease (CKD). We investigated the prevalence in patients with combined CHF/CKD and its association with renal function, cardiac dysfunction and the presence and extent of myocardial fibrosis.

Methods
The EPOCARES study (ClinTrialsNCT00356733) investigates the role of erythropoietin in anaemic patients with combined CHF/CKD. Eligible subjects underwent combined cardiac magnetic resonance imaging (cMRI), including late gadolinium enhancement, with magnetic resonance angiography of the renal arteries (MRA).

Results
MR study was performed in 37 patients (median age 74 years, eGFR 37.4 ± 15.6 ml/min, left ventricular ejection fraction (LVEF) 43.3 ± 11.2%), of which 21 (56.8%) had ARAS (defined as stenosis >50%). Of these 21 subjects, 8 (21.6%) had more severe ARAS >70% and 8 (21.6%) had a bilateral ARAS >50% (or previous bilateral PTA). There were no differences in age, NT-proBNP levels and medication profile between patients with ARAS versus those without. Renal function declined with the severity of ARAS (p = 0.03), although this was not significantly different between patients with ARAS versus those without. Diabetes mellitus was more prevalent in patients without ARAS (56.3%) against those with ARAS (23.8%) (p = 0.04). The presence and extent of late gadolinium enhancement, depicting myocardial fibrosis, did not differ (p = 0.80), nor did end diastolic volume (p = 0.60), left ventricular mass index (p = 0.11) or LVEF (p = 0.15). Neither was there a difference in the presence of an ischemic pattern of late enhancement in patients with ARAS versus those without.

Conclusions
ARAS is prevalent in combined CHF/CKD and its severity is associated with a decline in renal function. However, its presence does not correlate with a worse LVEF, a higher left ventricular mass or with the presence and extent of myocardial fibrosis. Further research is required for the role of ARAS in the pathophysiology of combined chronic heart and renal failure.
Immunomodulatory effect of water soluble extract separated from mycelium of Phellinus linteus on experimental atopic dermatitis
Authors: Hwang Ji Sun , Kwon Ho-Keun , Kim Jung-Eun , Rho Jeonghae , Im Sin-Hyeog 
Published: September 2012

AbstractBackgroundComplementary and alternative medicine (CAM) is becoming a popular treatment for modulating diverse immune disorders.Phellinus linteus(P. linteus) as one of the CAMs has been used to modulate cancers, inflammation and allergic activities.However, little evidence has been shown about its underlying mechanism of action by which it exerts a beneficial role in dermatological diseasein vivo. In this study, we examined the immunomodulatory effects ofP. linteuson experimental atopic dermatitis (AD) and elucidated its action mechanism.MethodsThe immunomodulatory effect of total extract ofP. linteuson IgE production by human myeloma U266B1 cells was measured by ELISA. To further identify the effective components,P. linteuswas fractionated into methanol soluble, water soluble and boiling water soluble extracts. Each extract was treated to U266B1 cells and primary B cells to compare their inhibitory effects on IgE secretion. To test thein vivoefficacy, experimental atopic dermatitis (AD) was established by alternative treatment of DNCB and house dust mite extract into BALB/c mice. Water soluble extract ofP. linteus(WA) or ceramide as a positive control were topically applied to ears of atopic mouse every day for 2 weeks and progression of the disease was estimated by the following criteria: (a) ear thickness, clinical score, (b) serum total IgE, IgG and mite specific IgE level by ELSIA, (c) histological examination of ear tissue by H&E staining and (d) cytokine profile of total ear cells and CD4+T cells by real time PCR and ELSIA.ResultsTreatment of total extracts ofP. linteusto U266B1 inhibited IgE secretion. Among the diverse extracts ofP. linteus, water soluble extract ofP. linteus(WA) significantly reduced the IgE production in primary B cells and B cell line U266B1. Moreover, treatment of WA reduced AD symptoms such as ear swelling, erythema, and dryness and decreased recruitment of lymphocyte into the inflamed site. Interestingly WA treatment significantly reduced IgE level without affecting IgG levels and also down-regulated the levels of pathogenic cytokines (IL-4, IL-13, IL-12 and IFN-γ) and chemokines (CCL17 and CCL22) involved in AD development.ConclusionsOur study indicates that protective effect of water soluble extract ofP. linteusin atopic dermatitis is mediated by inhibiting IgE production and expression of AD associated pathogenic cytokines as well as chemokines, suggesting the beneficial effect ofP. linteusto modulate allergic skin disease.
Randomized, Open-Label, Phase III Study Comparing Patupilone (EPO906) With Pegylated Liposomal Doxorubicin in Platinum-Refractory or -Resistant Patients With Recurrent Epithelial Ovarian, Primary Fallopian Tube, or Primary Peritoneal Cancer
Authors: Colombo Nicoletta , Kutarska Elzbieta , Dimopoulos Meletios , Bae Duk-Soo , Rzepka-Gorska Izabella , Bidzinski Mariusz , Scambia Giovanni , Engelholm Svend Aage , Joly Florence , Weber Dirk , El-Hashimy Mona , Li Jingjin , Souami Farida , Wing Patricia , Engelholm Silke , Bamias Aristotelis , Schwartz Peter 
Published: September 2012

PurposeThis study compared the efficacy and safety of patupilone with those of pegylated liposomal doxorubicin (PLD) in patients with platinum-refractory or -resistant epithelial ovarian, primary fallopian tube, or primary peritoneal cancer.Patients and MethodsPatients with three or fewer prior regimens were eligible if they had received first-line taxane/platinum-based combination chemotherapy and were platinum refractory or resistant. Patients were randomly assigned to receive patupilone (10 mg/m2intravenously every 3 weeks) or PLD (50 mg/m2intravenously every 4 weeks).ResultsA total of 829 patients were randomly assigned (patupilone, n = 412; PLD, n = 417). There was no statistically significant difference in overall survival (OS), the primary end point, between the patupilone and PLD arms (P = .195; hazard ratio, 0.93; 95% CI, 0.79 to 1.09), with median OS rates of 13.2 and 12.7 months, respectively. Median progression-free survival was 3.7 months for both arms. The overall response rate (all partial responses) was higher in the patupilone arm than in the PLD arm (15.5% v 7.9%; odds ratio, 2.11; 95% CI, 1.36 to 3.29), although disease control rates were similar (59.5% v 56.3%, respectively). Frequently observed adverse events (AEs) of any grade included diarrhea (85.3%) and peripheral neuropathy (39.3%) in the patupilone arm and mucositis/stomatitis (43%) and hand-foot syndrome (41.8%) in the PLD arm.ConclusionPatupilone did not demonstrate significant improvement in OS compared with the active control, PLD. No new or unexpected serious AEs were identified.
Point-of-care testing on admission to the intensive care unit: lactate and glucose independently predict mortality
Authors: Martin Jan , Blobner Manfred , Busch Raymonde , Moser Norman , Kochs Eberhard , Luppa Peter B. 
Published: September 2012

Abstract

Background: The aim of the study was to retrospectively investigate whether parameters of routine point-of-care testing (POCT) predict hospital mortality in critically ill surgical patients on admission to the intensive care unit (ICU).

Methods: Arterial blood analyses of 1551 patients on admission to the adult surgical ICU of the Technical University Munich were reviewed. POCT was performed on a blood gas analyser. The association between acid-base status and mortality was evaluated. Metabolic acidosis was defined by base excess (BE) <–2 mmol/L and, wherever applicable, subdivided into lactic acidosis by lactate >50% of BE, anion gap (AG)-acidosis by AG >16 mmol/L, hyperchloraemic acidosis by chloride >115 mmol/L. Metabolic alkalosis was defined by BE ≥3 mmol/L. Logistic regression analysis identified variables independently associated with mortality.

Results: Overall mortality was 8.8%. Mortality was greater in male patients (p=0.012). Mean age was greater in non-survivors (p<0.0005). Nine hundred and eighty-six patients showed no metabolic acid-base disorder (mortality 7.3%), thereof 26 patients with pCO2 >55 mm Hg (mortality 23.1%). Three hundred and seventy-seven patients presented with acidosis (mortality 11.4%), thereof 163 patients with lactic acidosis (mortality 19%). Mortality for alkalosis (174 patients) was 12.1%. Mean blood glucose level for non-survivors was higher compared to survivors (p<0.0005). Logistic regression analysis identified lactate, glucose, age, male gender as independent predictors of mortality.

Conclusions: Lactate and glucose on ICU admission independently predict mortality. BE and AG failed as prognostic markers. Lactic acidosis showed a high mortality rate implying that lactate levels should be obtained on ICU admission. Prevalence of hyperchloraemic acidosis was low. Metabolic alkalosis was associated with an increased mortality. Further studies on this disturbance and its attendant high mortality are warranted.
Efficacy of Family-Based Weight Control Program for Preschool Children in Primary Care
Authors: Quattrin Teresa , Roemmich James N. , Paluch Rocco , Yu Jihnhee , Epstein Leonard H. , Ecker Michelle A. 
Published: September 2012

OBJECTIVE:To test the efficacy of an innovative family-based intervention for overweight preschool-aged children and overweight parents conducted in the primary care setting.METHODS:Children with BMI ≥85th percentile and an overweight parent were randomized to intervention or information control (IC). Trained staff delivered dietary and physical/sedentary activities education to parents over 6 months (10 group meetings and 8 calls). Parents in the intervention received also behavioral modification. An intention-to-treat analysis was performed by using mixed analysis of variance models to test changes in child percent over BMI (%OBMI) and z-BMI and to explore potential moderators of group differences in treatment response.RESULTS:Ninety-six of 105 randomized families started the program: 46 children (31 girls/15 boys) in the intervention and 50 (33 girls/17 boys) in the IC, with 33 and 39 mothers and 13 and 11 fathers in intervention and IC, respectively. Baseline characteristics did not differ between groups. Children in the intervention group had greater %OBMI and z-BMI decreases at 3 and 6 months compared with those assigned to IC (P &lt; .0021). A greater BMI reduction over time was also observed in parents in the intervention compared with parents assigned to IC (P &lt; .0001). Child %OBMI and parent BMI changes were correlated (r = .31; P = .003). Children with greater baseline %OBMI were more likely to have a greater %OBMI decrease over time (P = .02).CONCLUSIONS:Concurrently targeting preschool-aged overweight youth and their overweight parents for behavioral weight control in a primary care setting reduced child %OBMI and parent BMI, with parent and child weight changes correlating.
Application of ICD Technology for Improvement of Well's Productivity and Extension of the Oil Well's Life in Samaria Field.
Authors: Ramirez Julieta Hernandez , Saldierna Nancy Evelyn , Mandujano Hector A. , Altamirano Rafael Guerrero 
Published: September 2012

Abstract
Every day new technologies are implemented in mature petroleum fields, in order to obtain better results more than those from conventional systems. It is well known that conventional wells have brought big challenges and benefits, from exploration to explotation in the mid 1990s. Nowadays, designing and constructing horizontal wells is part of PEMEX's Production Strategy, in addition to deploying new technologies that solve the new challenges of mature fields, such as PEMEX Samaria Oil Field.
In naturally fractured reservoirs and heterogeneous formations, the variable distribution of permeability through the well, results in a variation in the inflow of fluids along the wellbore. The geometry of wells is susceptible to generate channeling of undesirable fluids (water and gas) towards the heel of the well region due to pressure drop friction effect generated along of the horizontal section, which results in an increase in the pressure drop on the heel causing an uneven flow.
A horizontal completion can maximize the contact area with the reservoir through the extension of the well length, with the objective of decreasing the required drawdown to produce the same rate all along the lateral that would favor the recovery factor of the reservoir. Some operators have been using the Inflow Control Devices technology (ICD) for the last ten years in order to balance the fluid inflow along the horizontal section of the well, counteracting the effects of water, gas coning and the annular flow, to increase the productivity of the well.
This paper describes the first successful ICD application for a well in the Samaria Field in Tabasco, Mexico. The best practices applied and technical experiences learned support the well performance and the increase in the recovery factor of the reservoir. Historically, after the ICD application since March, 2011, production has been maintained without subjecting the well to workover or stimulation treatments. Moreover, until this date, the well performance shows 0.7% of water cut and 918 STB/day of oil rate.
Summarizing, the ICDs implementation in Samaria oil Field is extending the well life and assuring the well productivity. In addition, due to the excellent initial results, these have created high expectations of many applications of ICD technology in the Samaria Field and in other PEMEX fields. At the present, more than 15 wells are being considered for the implementation of ICD technology. It is believed that using this technology will benefit the asset economic value-added by changing the field development plans.