bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ouvertures
Authors: Jacquemin Dominique 
Published: September 2012

Résumé À partir d’une proposition de « théologie analogique », l’auteur plaide pour une démarche théologique qui reconnaisse l’humain comme capable de raison, de se questionner, de réfléchir avec d’autres et de se laisser déplacer. Cette démarche le reconnaît de plus comme porteur de capacités à concourir au langage théologique, même sans s’y rapporter dans une posture confessante car, dans la visée de co-construction ici postulée, ne devient-il pas co-créateur et du discours théologique et d’un discours de sens partageable par tous ? Telle serait également la condition pour que la théologie puisse accompagner l’action humaine, pour autant qu’elle en accepte la temporalité avec ce qu’elle implique d’inaccomplissement, tant de l’action que du sens et de sa parole.
Control of Allergen-Induced Inflammation and Hyperresponsiveness by the Metalloproteinase ADAMTS-12
Authors: Paulissen Geneviève , El Hour Mehdi , Rocks Natacha , Guéders Maud M. , Bureau Fabrice , Foidart Jean-Michel , Lopez-Otin Carlos , Noel Agnès , Cataldo Didier D. 
Published: September 2012

Abstract
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) constitute a family of endopeptidases related to matrix metalloproteinases. These proteinases have been largely implicated in tissue remodeling associated with pathological processes. Among them, ADAMTS12 was identified as an asthma-associated gene in a human genome screening program. However, its functional implication in asthma is not yet documented. The present study aims at investigating potential ADAMTS-12 functions in experimental models of allergic airways disease. Two different in vivo protocols of allergen-induced airways disease were applied to the recently generated Adamts12-deficient mice and corresponding wild-type mice. In this study, we provide evidence for a protective effect of ADAMTS-12 against bronchial inflammation and hyperresponsiveness. In the absence of Adamts12, challenge with different allergens (OVA and house dust mite) led to exacerbated eosinophilic inflammation in the bronchoalveolar lavage fluid and in lung tissue, along with airway dysfunction assessed by increased airway responsiveness following methacholine exposure. Furthermore, mast cell counts and ST2 receptor and IL-33 levels were higher in the lungs of allergen-challenged Adamts12-deficient mice. The present study provides, to our knowledge, the first experimental evidence for a contribution of ADAMTS-12 as a key mediator in airways disease, interfering with immunological processes leading to inflammation and airway hyperresponsiveness.
HLA-DM Constrains Epitope Selection in the Human CD4 T Cell Response to Vaccinia Virus by Favoring the Presentation of Peptides with Longer HLA-DM–Mediated Half-Lives
Authors: Yin Liusong , Calvo-Calle J. Mauricio , Dominguez-Amorocho Omar , Stern Lawrence J. 
Published: September 2012

Abstract
HLA-DM (DM) is a nonclassical MHC class II (MHC II) protein that acts as a peptide editor to mediate the exchange of peptides loaded onto MHC II during Ag presentation. Although the ability of DM to promote peptide exchange in vitro and in vivo is well established, the role of DM in epitope selection is still unclear, especially in human response to infectious disease. In this study, we addressed this question in the context of the human CD4 T cell response to vaccinia virus. We measured the IC50, intrinsic dissociation t1/2, and DM-mediated dissociation t1/2 for a large set of peptides derived from the major core protein A10L and other known vaccinia epitopes bound to HLA-DR1 and compared these properties to the presence and magnitude of peptide-specific CD4+ T cell responses. We found that MHC II–peptide complex kinetic stability in the presence of DM distinguishes T cell epitopes from nonrecognized peptides in A10L peptides and also in a set of predicted tight binders from the entire vaccinia genome. Taken together, these analyses demonstrate that DM-mediated dissociation t1/2 is a strong and independent factor governing peptide immunogenicity by favoring the presentation of peptides with greater kinetic stability in the presence of DM.
CD31 Exhibits Multiple Roles in Regulating T Lymphocyte Trafficking In Vivo
Authors: Ma Liang , Cheung Kenneth C. P. , Kishore Madhav , Nourshargh Sussan , Mauro Claudio , Marelli-Berg Federica M. 
Published: September 2012

AbstractThe role of CD31, an Ig-like molecule expressed by leukocytes and endothelial cells (ECs), in the regulation of T lymphocyte trafficking remains contentious. Using CD31-deficient mice, we show that CD31 regulates both constitutive and inflammation-induced T cell migration in vivo. Specifically, T cell:EC interactions mediated by CD31 molecules are required for efficient localization of naive T lymphocytes to secondary lymphoid tissue and constitutive recirculation of primed T cells to nonlymphoid tissues. In inflammatory conditions, T cell:EC CD31-mediated interactions facilitate T cell recruitment to Ag-rich sites. However, endothelial CD31 also provides a gate-keeping mechanism to limit the rate of Ag-driven T cell extravasation. This event contributes to the formation of Ag-specific effector T cell infiltrates and is induced by recognition of Ag on the endothelium. In this context, CD31 engagement is required for restoring endothelial continuity, which is temporarily lost upon MHC molecule ligation by migrating cognate T cells. We propose that integrated adhesive and signaling functions of CD31 molecules exert a complex regulation of T cell trafficking, a process that is differentially adapted depending on cell-specific expression, the presence of inflammatory conditions and the molecular mechanism facilitating T cell extravasation.
On Hilbert Covariants
Authors: Abdesselam Abdelmalek , Chipalkatti Jaydeep 
Published: September 2012

AbstractLet F denote a binary form of order d over the complex numbers. If r is a divisor of d, then the Hilbert covariant Hr,d(F) vanishes exactly when F is the perfect power of an order r form. In geometric terms, the coefficients of H give defining equations for the image variety X of an embedding Pr ↪	Pd. In this paper we describe a new construction of the Hilbert covariant and simultaneously situate it into a wider class of covariants called the Göttingen covariants, all of which vanish on X. We prove that the ideal generated by the coefficients of H defines X as a scheme. Finally, we exhibit a generalisation of the Göttingen covariants to n-ary forms using the classical Clebsch transfer principle.
From Quantum Groups to Groups
Authors: Kalantar Mehrdad , Neufang Matthias 
Published: September 2012

AbstractIn this paper we use the recent developments in the representation theory of locally compact quantum groups, to assign to each locally compact quantum group 𝔾 a locally compact group 𝔾˜ that is the quantum version of point-masses and is an invariant for the latter. We show that “quantum point-masses” can be identified with several other locally compact groups that can be naturally assigned to the quantum group 𝔾. This assignment preserves compactness as well as discreteness (hence also finiteness), and for large classes of quantum groups, amenability. We calculate this invariant for some of the most well-known examples of non-classical quantum groups. Also, we show that several structural properties of 𝔾 are encoded by 𝔾˜; the latter, despite being a simpler object, can carry very important information about 𝔾.
Prevalence and Risk Factor associated with Musculoskeletal Pain among Students of MGM Dental College: A Cross- Sectional Survey
Authors: Madaan Vishwas , Chaudhari Amit 
Published: September 2012

ABSTRACT

Background
The aim of this study was to determine the prevalence and associated risk factors for development of musculoskeletal pain among the dental students of 3rd, 4th year and interns, at MGM Dental College, Navi Mumbai.

Materials and Methods
A valid and reliable close ended questionnaire was administered to 230 students of 3rd year, 4th year and interns who met the inclusion criteria. A response rate of 77% was achieved. The variables included in the questionnaire were (1) presence of pain, (2) awareness regarding correct posture, (3) areas of the body affected by pain, (4) clinical setting, (5) practices to reduce pain. Statistical analysis was applied using Chi-square test.

Results
In this study, we found a total of 81% prevalence of musculoskeletal pain among the dental students. Eighty-one percent were unaware of the correct posture for dental clinical procedures.
Statistical significance was observed between different clinical activities and musculoskeletal pain when Chi-square test was applied. Maximum pain was observed in the hand (92%) followed by wrist (85%) and lower back (72%). Sixty-three percent of the students having pain performed cervical flexions and torsions to improve vision of the oral cavity. Seventy-five percent of the students reported that they were uncomfortable with their current working stool. Five percent of the participants performed exercises after clinical practice of which none reported musculoskeletal pain.

Conclusion
Dental students are prone to development of musculoskeletal pain due to lack of awareness regarding correct posture, prolonged static postures, inadequate operating stools and lack of exercises.

How to cite this article
Madaan V, Chaudhari A. Prevalence and Risk Factor associated with Musculoskeletal Pain among Students of MGM Dental College: A Cross-Sectional Survey. J Contemp Dent 2012;2(2):22-27.
Stress and the Periodontium
Authors: Sharma Nisha , Gujjari Sheela Kumar , Kanagotagi Sachin 
Published: September 2012

ABSTRACTStress or tension is an unavoidable part of human life. It has been proven to cause not only health-related problems but problems pertaining to periodontium too. These include periodontal pocket formation, apical migration of junctional epithelium and delated wound healing. This paper connects the link between stress, its effect on general health and consequently on oral health.How to cite this articleSharma N, Gujjari SK, Kanagotagi S. Stress and the Periodontium. J Contemp Dent 2012;2(2):28-30.
Orthokeratinized Odontogenic Cyst
Authors: Swain Niharika , Poonja LS , Dekate Kamlesh 
Published: September 2012

ABSTRACTOrthokeratinized odontogenic cyst (OOC) is a developmental cyst of odontogenic origin and was initially defined as the uncommon orthokeratinized variant of odontogenic keratocyst (OKC). However, recently World Health Organization has designated OOC as a distinct clinicopathologic entity as it has peculiar clinicopathologic aspects when compared to other developmental odontogenic cysts, especially OKCs. The orthokeratinized odontogenic cyst is histologically characterized by a thin, uniform, epithelial lining with orthokeratinization and a subjacent prominent granular cell layer. The purpose of the article is to present a case of OOC arising in the anterior mandible, an unusual site for the lesion and also highlights the importance of distinguishing it from the more commonly occurring keratocystic odontogenic tumor (KCOT).How to cite this articleSwain N, Patel S, Poonja LS, Pathak J, Dekate K. Orthokeratinized Odontogenic Cyst. J Contemp Dent 2012;2(2):31-33.
Foreign Object Lodgment in the Root Canal and Its Management: A Case Report and an Overview
Authors: Grover Charu , Thomas Manuel S , Pai AR Vivekananda 
Published: September 2012

ABSTRACTSelf-introduced foreign object by an adult into the root canal of a lower incisor is seldom reported in the endodontic literature. This case report describes a self-introduced unusual foreign body and its retrieval from the root canal of lower left lateral incisor. A persistent sinus tract resistant to calcium hydroxide intracanal medicament was then successfully treated with the use of triple antibiotic paste. Postendodontically, nonvital bleaching and composite resin restoration was used to restore the form, function and esthetics of the tooth in a conservative manner.How to cite this articleGrover C, Thomas MS, Pai ARV. Foreign Object Lodgment in the Root Canal and Its Management: A Case Report and an Overview. J Contemp Dent 2012;2(2):47-52.
Concise Review: Therapeutic Potential of Adipose Tissue-Derived Angiogenic Cells
Authors: Szöke Krisztina , Brinchmann Jan E. 
Published: September 2012

Abstract
Inadequate blood supply to tissues is a leading cause of morbidity and mortality today. Ischemic symptoms caused by obstruction of arterioles and capillaries are currently not treatable by vessel replacement or dilatation procedures. Therapeutic angiogenesis, the treatment of tissue ischemia by promoting the proliferation of new blood vessels, has recently emerged as one of the most promising therapies. Neovascularization is most often attempted by introduction of angiogenic cells from different sources. Emerging evidence suggests that adipose tissue (AT) is an excellent reservoir of autologous cells with angiogenic potential. AT yields two cell populations of importance for neovascularization: AT-derived mesenchymal stromal cells, which likely act predominantly as pericytes, and AT-derived endothelial cells (ECs). In this concise review we discuss different physiological aspects of neovascularization, briefly present cells isolated from the blood and bone marrow with EC properties, and then discuss isolation and cell culture strategies, phenotype, functional capabilities, and possible therapeutic applications of angiogenic cells obtained from AT.
Temporal changes in cardiorespiratory fitness and the incidence of hypertension in initially normotensive subjects
Authors: Jae Sae Young , Heffernan Kevin S. , Yoon Eun Sun , Park Soo Hyun , Carnethon Mercedes R. , Fernhall Bo , Choi Yoon‐Ho , Park Won Hah 
Published: September 2012

AbstractObjectives:Low‐cardiorespiratory fitness (CRF) has been associated with incident hypertension, but whether temporal changes in CRF are associated with incident hypertension in initially normotensive subjects are not known. We investigated the relationship of baseline CRF and longitudinal changes in CRF with incident hypertension in initially normotensive subjects.Methods:Subjects were 3,831 men who participated in two health examinations during 1998–2009. All subjects were free of cardiovascular diseases and hypertension at baseline. CRF was directly measured by peak oxygen uptake using expired gas analysis during a standard treadmill test.Results:During an average of 5 years of follow‐up, 373 (9.7%) subjects developed hypertension. The incidence of hypertension was inversely associated with baseline CRF quartiles [Q1 (lowest) 11.8%, Q2 10.4%, Q3 9.1%, and Q4 (highest) 7.5%; P < 0.05 for trend]. The relative risk (RR) of incident hypertension in the lowest CRF quartile versus the highest CRF quartile was 1.69 (95% CI: 1.22–2.34) after adjustment for risk factors. Each metabolic equivalent increment higher peak oxygen uptake at baseline examination was associated with 10% (RR 0.90, 95% CI: 0.83–0.98) lower incidence of hypertension in multivariate adjusted model. Subjects whose CRF decreased (<−1.18 ml/kg/min per year) over time had a 72% increased risk in developing hypertension (RR 1.72, 95% CI: 1.20–2.49) compared to subjects with increased CRF (>0.13 ml/kg/min per year) after adjustment for risk factors.Conclusion:These results demonstrate that both baseline CRF levels and changes in CRF over time were associated with the incidence of hypertension independent of risk factors. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc.
The earliest evidence of millet as a staple crop: New light on neolithic foodways in North China
Authors: Liu Xinyi , Jones Martin K. , Zhao Zhijun , Liu Guoxiang , O'Connell Tamsin C. 
Published: September 2012

AbstractThere is a growing body of archaeobotanical evidence for the harvesting of millet in Eurasia prior to 5,000 cal. BC. Yet direct evidence for the extent of millet consumption in this time period is rare. This contradiction may be due to millet crops making only a minor contribution to the diet before 5,000 BC. In this article, drawing from recent excavations in North China, we present evidence for millet crops making a substantial contribution to human and animal diets in periods, which correspond chronologically with the time depth of the archaeobotanical record. We infer that in eastern Inner Mongolia, human adoption of millets, which may or may be not related to substantial agriculture, happened at the Early Neolithic, with direct dates between 5,800 and 5,300 cal. BC. Am J Phys Anthropol 149:283–290, 2012. © 2012 Wiley Periodicals, Inc.
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis
Authors: Buck Dorothea , Albrecht Eva , Aslam Muhammad , Goris An , Hauenstein Natalie , Jochim Angela ,   International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium, Cepok Sabine , Grummel Verena , Dubois Bénédicte , Berthele Achim , Lichtner Peter , Gieger Christian , Winkelmann Juliane , Hemmer Bernhard 
Published: September 2012

AbstractObjective:Intrathecal synthesis of immunoglobulin gamma (IgG) synthesis is frequently observed in patients with multiple sclerosis (MS). Whereas the extent of intrathecal IgG synthesis varies largely between patients, it remains rather constant in the individual patient over time. The aim of this study was to identify common genetic variants associated with the IgG index as a marker of intrathecal IgG synthesis in MS.Methods:We performed a genome‐wide association study of the IgG index in a discovery series of 229 patients. For confirmation we performed a replication in 2 independent series comprising 256 and 153 patients, respectively. The impact of associated single nucleotide polymorphisms (SNPs) on MS susceptibility was analyzed in an additional 1,854 cases and 5,175 controls.Results:Significant association between the IgG index and 5 SNPs was detected in the discovery and confirmed in both replication series reaching combined p values of p = 6.5 × 10−11 to p = 7.5 × 10−16. All identified SNPs are clustered around the immunoglobulin heavy chain (IGHC) locus on chromosome 14q32.33 and are in linkage disequilibrium (r2 range, 0.71–0.95). The best associated SNP is located in an intronic region of the immunoglobulin gamma3 heavy chain gene. Additional sequencing identified the GM21* haplotype to be associated with a high IgG index. Further evaluation of the IGHC SNPs revealed no association with susceptibility to MS in our data set.Interpretation:The extent of intrathecal IgG in MS is influenced by the IGHC locus. No association with susceptibility to MS was found. Therefore GM haplotypes might affect intrathecal IgG synthesis independently of the underlying disease. ANN NEUROL 2013
Electron transfer dynamics of peptide‐derivatized RuII‐polypyridyl complexes on nanocrystalline metal oxide films
Authors: Hanson Kenneth , Wilger Dale J. , Jones Sean T. , Harrison Daniel P. , Bettis Stephanie E. , Luo Hanlin , Papanikolas John M. , Waters Marcey L. , Meyer Thomas J. 
Published: September 2012

AbstractThe performance of dye‐sensitized solar and photoelectrochemical cells is strongly dependent on the electron transfer events at the electrode‐sensitizer interface. Surface‐bound peptides derivatized with chromophores have not been used in dye‐sensitized solar and photoelectrochemical cells, but they have properties for these applications that could be advantageous by exploiting secondary structure and the attachment of multiple chromophores. In this manuscript, we have investigated structure–property relationships for three metallopeptide‐based assemblies to solution and chemically bound to nanocrystalline MO2 (M = Ti, Zr) films. A particular interest was exploring the influence of increasing separation distance between a common chromophore, [Ru(bpy)2(4‐Me‐4′‐(NHCO)bpy)]2+, and the underlying oxide substrate on excited and ground state electron transfer. Rates of Ru(II) oxidation to Ru(III) at the interface were measured by cyclic voltammetry on fluorine‐doped tin oxide and cross‐surface electron transfer on TiO2. Excited state injection by [RuIII(bpy)2(bpy−)]2+ was monitored by transient absorption and time‐resolved emission. There are discernible trends in the electron transfer rate data with approximated, fully extended distances between the [Ru(bpy)2(4‐Me‐4′‐(NHCO)bpy)]2+ sites and the interface. However, the distance dependences that are observed are smaller than anticipated, a result consistent with a lack of ordered secondary structure in the surface‐bound peptide chains and a distribution of local orientations. For the surface‐bound excited states, only a small fraction undergo quenching by electron transfer to TiO2, presumably from those oriented near the surface. © 2012 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 25–37, 2013.
β2 and γ3 laminins are critical cortical basement membrane components: Ablation of Lamb2 and Lamc3 genes disrupts cortical lamination and produces dysplasia
Authors: Radner Stephanie , Banos Charles , Bachay Galina , Li Yong N. , Hunter Dale D. , Brunken William J. , Yee Kathleen T. 
Published: September 2012

AbstractCortical development is dependent on the timely production and migration of neurons from neurogenic sites to their mature positions. Mutations in several receptors for extracellular matrix (ECM) molecules and their downstream signaling cascades produce dysplasia in brain. Although mutation of a critical binding site in the gene that encodes the ECM molecule laminin γ1 (Lamc1) disrupts cortical lamination, the ECM ligand(s) for many ECM receptors have not been demonstrated directly in the cortex. Several isoforms of the heterotrimeric laminins, all containing the β2 and γ3 chain, have been isolated from the brain, suggesting they are important for CNS function. Here, we report that mice homozygous null for the laminin β2 and γ3 chains exhibit cortical laminar disorganization. Mice lacking both of these laminin chains exhibit hallmarks of human cobblestone lissencephaly (type II, nonclassical): they demonstrate severe laminar disruption; midline fusion; perturbation of Cajal‐Retzius cell distribution; altered radial glial cell morphology; and ectopic germinal zones. Surprisingly, heterozygous mice also exhibit laminar disruption of cortical neurons, albeit with lesser severity. In compound null mice, the pial basement membrane is fractured, and the distribution of a key laminin receptor, dystroglycan, is altered. These data suggest that β2 and γ3‐containing laminins play an important dose‐dependent role in development of the cortical pial basement membrane, which serves as an attachment site for Cajal‐Retzius and radial glial cells, thereby guiding neural development. © 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2013