bluuebunny/crossref_metadata_2025_split huggingface dataset:
18F-fluoro-deoxyglucose positron emission tomography/computed tomography scan findings in Rosai-Dorfman disease with IgG4-positive plasma cell infiltration mimicking breast malignancy: a case report and literature review
Authors: Fu Liping , Liu Mei , Song Zhigang , Xu Baixuan , Tian Jiahe 
Published: November 2012

Abstract

Introduction
Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a rare benign disorder characterized histologically by lymphatic sinus dilatation due to histiocyte proliferation. Rosai-Dorfman disease accompanied by IgG4+ plasma cell infiltration is an even rarer situation. To the best of our knowledge, no imaging report of fluoro-deoxyglucose positron emission tomography/computed tomography findings of Rosai-Dorfman disease with IgG4+ plasma cell infiltration has been published, although a series of pathological research has focused on this phenomenon.

Case presentation
We reviewed the 18F-fluoro-deoxyglucose positron emission tomography/computed tomography scan of a 78-year-old Chinese woman with a solid mass that was found in her right breast during a health checkup. 18F-fluoro-deoxyglucose positron emission tomography/computed tomography showed a hypermetabolic nodule in her right breast and slightly heterogeneous increased fluoro-deoxyglucose uptake of the pulmonary nodules, which were histologically proven to be mammary Rosai-Dorfman disease with IgG4+ plasma cell infiltration and pulmonary amyloidosis, respectively. A literature review was performed to gather information on this rare disease process.

Conclusions
Although distinguishing benign lymphoplasmacytic proliferation from malignancy may be difficult with 18F-fluoro-deoxyglucose positron emission tomography/computed tomography in light of the pattern and intensity of fluoro-deoxyglucose uptake, our case highlights that whole-body positron emission tomography/computed tomography imaging not only can display the extent of the disease to help complete staging but also can provide functional information about disease activity to guide biopsy.
Pneumonitis and pulmonary fibrosis in a patient receiving adjuvant docetaxel and cyclophosphamide for stage 3 breast cancer: a case report and literature review
Authors: Ochoa Roberto , Bejarano Pablo A , Glück Stefan , Montero Alberto J 
Published: November 2012

Abstract

Introduction
Pulmonary toxicities associated with chemotherapeutic agents utilized as adjuvant therapy in patients with breast cancer are distinctly uncommon. The chemotherapy regimen of docetaxel/cyclophosphamide has a more favorable therapeutic index compared to anthracycline-based regimens due to a significantly lower incidence of heart failure and leukemia. Consequently, docetaxel/cyclophosphamide is the preferred adjuvant chemotherapy of choice in older women or in women where anthracyclines may be contraindicated. Pulmonary complications in patients with breast cancer receiving taxane-based adjuvant chemotherapy in the absence of radiation are distinctly uncommon. Here, we report the case of a patient receiving adjuvant docetaxel/cyclophosphamide who developed rapid-onset, biopsy-proven interstitial pneumonitis.

Case presentation
A 72-year-old Hispanic woman was diagnosed as having stage 3 hormone-receptor positive, human epidermal growth factor receptor 2/neu negative, invasive breast cancer. Due to the estimated 10-year risk of recurrence of approximately 80 percent, a decision was made to treat our patient with adjuvant chemotherapy. Due to her age and increased risk of cardiac toxicity with anthracycline-based chemotherapy regimens, our patient was treated with docetaxel/cyclophosphamide chemotherapy for a total of four planned cycles. However, approximately two weeks after receiving the third cycle of chemotherapy, our patient developed rapidly progressive dyspnea, and a non-productive cough and went to the emergency room at an outside medical facility. She was found to have mild hypoxemia, and new onset of peripheral, subpleural fibrotic changes not present on pre-treatment scans. A thorascopic-guided wedge biopsy of the lung tissue revealed subacute interstitial pneumonitis. Our patient made a rapid clinical recovery after treatment with corticosteroids.

Conclusions
Interstitial pneumonitis is a rare complication of docetaxel/cyclophosphamide chemotherapy that carries a high mortality rate. The only way to make a definitive diagnosis is with a wedge biopsy of the lung, which should be performed when feasible. Our patient’s case illustrates that no therapeutic intervention is without its intrinsic and unanticipated risks, and interstitial pneumonitis should be discussed as a potential side effect with all patients prior to administering docetaxel/cyclophosphamide chemotherapy.
Does use of the CONSORT Statement impact the completeness of reporting of randomised controlled trials published in medical journals? A Cochrane reviewa
Authors: Turner Lucy , Shamseer Larissa , Altman Douglas G , Schulz Kenneth F , Moher David 
Published: November 2012

Abstract

Background
The Consolidated Standards of Reporting Trials (CONSORT) Statement is intended to facilitate better reporting of randomised clinical trials (RCTs). A systematic review recently published in the Cochrane Library assesses whether journal endorsement of CONSORT impacts the completeness of reporting of RCTs; those findings are summarised here.

Methods
Evaluations assessing the completeness of reporting of RCTs based on any of 27 outcomes formulated based on the 1996 or 2001 CONSORT checklists were included; two primary comparisons were evaluated. The 27 outcomes were: the 22 items of the 2001 CONSORT checklist, four sub-items describing blinding and a ‘total summary score’ of aggregate items, as reported. Relative risks (RR) and 99% confidence intervals were calculated to determine effect estimates for each outcome across evaluations.

Results
Fifty-three reports describing 50 evaluations of 16,604 RCTs were assessed for adherence to at least one of 27 outcomes. Sixty-nine of 81 meta-analyses show relative benefit from CONSORT endorsement on completeness of reporting. Between endorsing and non-endorsing journals, 25 outcomes are improved with CONSORT endorsement, five of these significantly (α = 0.01). The number of evaluations per meta-analysis was often low with substantial heterogeneity; validity was assessed as low or unclear for many evaluations.

Conclusions
The results of this review suggest that journal endorsement of CONSORT may benefit the completeness of reporting of RCTs they publish. No evidence suggests that endorsement hinders the completeness of RCT reporting. However, despite relative improvements when CONSORT is endorsed by journals, the completeness of reporting of trials remains sub-optimal. Journals are not sending a clear message about endorsement to authors submitting manuscripts for publication. As such, fidelity of endorsement as an ‘intervention’ has been weak to date. Journals need to take further action regarding their endorsement and implementation of CONSORT to facilitate accurate, transparent and complete reporting of trials.
Kinematics of the ribbon fin in hovering and swimming of the electric ghost knifefish
Authors: Ruiz-Torres Ricardo , Curet Oscar M. , Lauder George V. , MacIver Malcolm A. 
Published: November 2012

SummaryWeakly electric knifefish are exceptionally maneuverable swimmers. In prior work, we have shown that they are able to move their entire body omnidirectionally so that they can rapidly reach prey up to several centimeters away. Consequently, in addition to being a focus of efforts to understand the neural basis of sensory signal processing in vertebrates, knifefish are increasingly the subject of biomechanical analysis to understand the coupling of signal acquisition and biomechanics. Here, we focus on a key subset of the knifefish's omnidirectional mechanical abilities: hovering in place, and swimming forward at variable speed. Using high speed video and a markerless motion capture system to capture fin position, we show that hovering is achieved by generating two traveling waves, one from the caudal edge of the fin, and one from the rostral edge, moving toward each other. These two traveling waves overlap at a nodal point near the center of the fin, cancelling fore-aft propulsion. During forward swimming at low velocities, the caudal region of the fin continues to have counter-propagating waves, directly retarding forward movement. The gait transition from hovering to forward swimming is accompanied by a shift in the nodal point toward the caudal end of the fin. While frequency varies significantly to increase speed at low velocities, beyond about one body length per second, the frequency stays near 10~Hz, and amplitude modulation becomes more prominent despite its higher energetic costs. A coupled central pattern generator model is able to reproduce qualitative features of fin motion and suggest hypotheses regarding the fin's neural control.
Photo-orientation regulates seasonal habitat selection in the two-spotted spider miteTetranychus urticae
Authors: Suzuki Takeshi , Kojima Takeshi , Takeda Makio , Sakuma Masayuki 
Published: November 2012

SummaryNon-diapausing spider mites (Tetranychus urticae) live on the undersurface of host leaves during summer, but diapausing mites overwinter in dark hibernacula. The light environments of these habitats would differ: visible radiation (VIS) but not ultraviolet radiation (UV) would reach the undersurface, but neither would enter dark hibernacula. Thus, mites of either seasonal form could locate their preferred habitat by photo-orientation responses to UV and VIS. To investigate this possibility, we analysed the mites’ locomotion behaviour on a virtual field with a programmed chequered pattern of light and dark patches in a micro-locomotion compensator. Both non-diapausing and diapausing mites moved away from UV-illuminated patches into dark patches. Non-diapausing mites moved towards VIS-illuminated patches, whereas diapausing mites did not show a preference. Our results show that non-diapausing mites avoid UV and are attracted to VIS, suggesting that this can guide them beneath a leaf. Diapausing mites simply avoid UV. The lack of preference for VIS during diapause could be due to changes in carotenoid metabolism, which also involve orange pigmentation of diapausing mites. We consider that a diapause-mediated switch of the response to VIS, together with regular avoidance of UV, plays a key role in the seasonal change of habitat selection in this species. This seasonal polyphenism involves alterations not only in reproductive state and pigmentation, but also in photo-spectral responses.
Nitric oxide signaling differentially affects habitat choice by two larval morphs of the sea slugAlderia willowi: mechanistic insight into evolutionary transitions in dispersal strategies.
Authors: Romero Melissa R. , Phuong Mark A. , Bishop Cory D. , Krug Patrick J. 
Published: November 2012

SummaryIn many marine animals, adult habitat is selected by lecithotrophic (non-feeding) larvae with a limited lifespan. In generalist species, larvae may increasingly accept sub-optimal habitat over time as energy stores are depleted (‘desperate larva’ hypothesis). If the fitness cost of suboptimal habitat is too high, larvae of specialists may prolong the searching phase until encountering a high-quality patch or dying (‘death before dishonor’ hypothesis). In generalists, starvation is hypothesized to lead to a decline in inhibitory nitric oxide (NO) signaling, thereby triggering metamorphosis. Here, we document alternative functions for identified signaling pathways in larvae having ‘desperate’ versus ‘death before dishonor’ strategies in lecithotrophic clutches of a habitat specialist, the sea slug Alderia willowi. In an unusual dimorphism, each clutch of A. willowi hatches both non-selective larvae that settle soon after hatching, and siblings that delay settlement in the absence of cues from the alga Vaucheria, the sole adult food. Phamacological manipulation of NO signaling induced metamorphosis in non-selective but not selective stages. However, decreased NO signaling in selective larvae lowered the threshold for response to habitat cues, mimicking the effect of declining energy levels. Manipulation of cGMP or dopamine production induced metamorphosis in selective and non-selective larvae alike, highlighting a distinct role for the NO pathway in the two larval morphs. We propose a model in which NO production (i) links nitrogen metabolism with sensory receptor signaling, and (ii) shifts from a regulatory role in ‘desperate larva’ strategies to a modulatory role in ‘death-before-dishonor’ strategies. This study provides new mechanistic insight into how the function of conserved signaling pathways may change in response to selection on larval habitat choice behaviors.
Utilization of Carboxylated 1,3-Indandione as an Electron Acceptor in Dye-Sensitized Solar Cells
Authors: Matsumoto Shoji , Aoki Tatsuro , Suzuki Tasutaka , Akazome Motohiro , Betto Atsushi , Suda Yasumasa 
Published: November 2012

Abstract
The performance of dyes containing carboxylated 1,3-indandiones as electron acceptors was examined. The compounds that included a monocarboxylic group on the 1,3-indandione moiety showed good overall power conversion efficiencies (ca. 2.38%), the values of which were comparable to those of cyanoacrylate derivatives with the same donor–π-linker structure.
Synthesis and Characterization of 2,3,9,10-Tetradendronized Pentacene
Authors: Tajima Tomoyuki , Yamakawa Akio , Fukuda Keitaro , Hayashi Yuuki , Nakano Masahiko , Takaguchi Yutaka 
Published: November 2012

Abstract
A new pentacene dendrimer was synthesized in 81% yield through the aromatization of a dihydropentacene derivative having benzyl ether dendrons at the C2, C3, C9, and C10 positions. The dendrimer is very soluble in various organic solvents such as toluene, benzene, chloroform, dichloromethane, acetone, and ethyl acetate. The half-life of the dendrimer reaches 22.4 min upon photoirradiation in air. Interestingly, regiospecific [4 + 2] cycloaddition reactions proceeded at the central ring of the pentacene.
Carbon Dioxide-promoted Selective Reductive Amination of Aliphatic Ketones with Aniline and Hydrogen Using a Pt/C Catalyst
Authors: Ichikawa Shinichiro , Seki Tsunetake , Ikariya Takao 
Published: November 2012

Abstract
Product selectivity in the reductive amination of aliphatic ketones with aniline and H2 using a 5% Pt/C catalyst was improved remarkably in the presence of CO2. The CO formed in situ by the reverse water–gas shift reaction selectively poisoned the Pt sites active for undesired side reactions.
3D-ordered Nanoporous LiMPO4 (M = Fe, Mn)–Carbon Composites with Excellent Charging–Discharging Rate-capability
Authors: Moriguchi Isamu , Nabeyoshi Shohei , Izumi Mayato , Yamada Hirotoshi 
Published: November 2012

Abstract
Highly ordered and three-dimensionally interconnected nanoporous materials, constructed with a nanothick wall of LiMPO4 (M = Fe, Mn) and a carbon (C) nanocomposite, were successfully synthesized by a colloidal crystal-template process. It was demonstrated for the first time that the ordered nanoporous composites show excellent rate capability not only for LiFePO4 but also for LiMnPO4.
Synthesis and Characterization of Reduction-responsive Cyclophane Dimer Based on Disulfide Linkage
Authors: Hayashida Osamu , Ichimura Kazuaki 
Published: November 2012

Abstract
Reduction-responsive cyclophane dimer having a disulfide linkage was synthesized. The host showed enhanced guest binding affinity relative to that by monocyclic cyclophane, as confirmed by fluorescence spectroscopy. Reduction of the disulfide bond of the host by dithiothreitol gave monocyclic cyclophanes having less guest-binding affinity.
Revenue Sharing in Airline Alliances
Authors: Hu Xing , Caldentey René , Vulcano Gustavo 
Published: November 2012

We propose a two-stage game-theoretic approach to study the operations of an airline alliance in which independent carriers, managing different reservation and information systems, can collaboratively market and operate codeshare and interline itineraries. In the first-stage game, airlines negotiate fixed proration rates to share the revenues generated by such itineraries. In the second-stage game, airlines operate independent inventory control systems to maximize their own expected revenues. We derive a revenue-sharing rule that is (i) an admissible outcome of the first-stage negotiation, in the sense that no airline coalition has enough incentives to secede from the grand alliance, and (ii) efficient for the second-stage game, in the sense that the decentralized system can achieve the same revenues as a central planner managing the global alliance network. Our numerical study shows that the proposed proration rates can lead to a significant increase in revenues with respect to other rules commonly used in practice. Finally, because our proposal requires the disclosure of private demand information, we introduce a simple alternative rule that is based on public information. This heuristic performs remarkably well, becoming an interesting candidate to be pursued in practice. This paper was accepted by Martin Lariviere, operations management.
Long-term skeletal consequences of childhood acute lymphoblastic leukemia in adult males: a cohort study
Authors: Mäkitie O , Heikkinen R , Toiviainen-Salo S , Henriksson M , Puukko-Viertomies L-R , Jahnukainen K 
Published: November 2012

ObjectiveLong-term health sequelae of childhood-onset acute lymphoblastic leukemia (ALL) remain largely unknown. Low bone mineral content (BMC) and bone mineral density (BMD) are recognized complications, but it is unknown whether these persist until adulthood. We evaluated skeletal characteristics and their association with ALL therapy in long-term male ALL survivors.DesignThis cross-sectional cohort study included 49 long-term male ALL survivors and 55 age-matched healthy males.MethodsBMD and compression fractures were assessed by dual-energy X-ray absorptiometry; blood biochemistry was obtained for parameters of calcium homeostasis.ResultsThe ALL survivors (median age 29 years, range 25–38 years), assessed 10–38 years after ALL diagnosis, had lower lumbar spine (P<0.001), femoral neck (P<0.001), and whole-body (P=0.017) BMD than expected based on normative values. When compared with the controls (median age 30 years, range 24–36 years), the ALL survivors had lower lumbar spine BMC (P=0.014), lower whole-body BMC (P<0.001), and lower whole-body BMD (P<0.001), but the differences were partly explained by differences in height. Altogether, 20% of the ALL survivors had spinal compression fractures, but these were equally prevalent in the controls. Males diagnosed with ALL before age 5 years had significantly lower BMD values. Other recognized risk factors included untreated hypogonadism, vitamin D deficiency, hypophosphatemia, low IGF-binding protein-3, and low physical activity.ConclusionsAt young adulthood, long-term male ALL survivors have significantly reduced BMC and BMD and a high prevalence of spinal compression fractures. Careful follow-up and active treatment of the recognized risk factors are warranted.
Hardening Mechanism through Phase Separation of Beta Ti-35Nb-7Zr-5Ta and Ti-35Nb-7Ta Alloys
Authors: Afonso C. R. M. , Ferrandini P. L. , Caram R. 
Published: November 2012

AbstractThe β titanium alloys are highly attractive metallic materials for biomedical applications due to their high specific strength, high corrosion resistance and excellent biocompatibility, including low elastic modulus. The aim of this work is the evaluation of hardening mechanism through phase separation in β Ti-35Nb-7Zr-5Ta (TNZT) and Ti-35Nb-7Ta (TNT) alloys. Ingots (50 g) of TNZT and TNT alloys were arc-furnace melted in Ar(g)atmosphere. XRD using synchrotron radiation together with TEM and HRTEM analysis showed the coexistence of two separated phases (β and β’) with similar crystalline structures and slightly different lattice parameters in TNZT and TNT alloys. It was detected a heterogeneous microstructure alternating nanosized dark and bright regions (∼10 nm) with different compositions (Nb-rich β and Ta-Zr-rich β’).In aged condition (400ºC/4h), TNZT and TNT alloys undergoes coherent spinodal decomposition of β phase into two solid solution phases with coherent interface, different compositions and elastic strain associated with nanometric domains of Nb-rich β and Ta-(Zr)-rich β’ phases.
Arabinoxylans Gels as Lycopene Carriers: in vitro Degradation by Colonic Bacteria
Authors: Rascón-Chu A. , Martínez-López A. L. , Berlanga-Reyes C. , Carvajal-Millan E. , Campa-Mada A. C. , Gardea A. A. , Orozco-Avitia A. 
Published: November 2012

ABSTRACTArabinoxylans are polysaccharides constituted of a linear backbone of xylose in which arabinose substituents are attached, some ferulic acid esterifies arabinose. Arabinoxylan can form covalent gels by oxidative coupling of ferulic acid. Arabinoxylan gels could have potential applications for colon-specific biomolecules delivery due to their macroporous structure, and their aqueous environment and their dietary fiber nature. Lycopene has received increasing attention for its possible role in the prevention of colon cancer. It has been previously reported that arabinoxylan gels could be formed in presence of lycopene with no detriment on the lycopene antioxidant activity. The objective of this research was to investigate the in vitro degradation of arabinoxylan gels (AX gels) by two human colon bacterial species (Bacteroides ovatus and Bifidobacterium longum). Bacterial counts (CFU ml-1) and metabolic heat production (p) followed a similar pattern with a high response during the first 24 h at 37 °C. A regression model related CFU ml-1 and p (r2= 0.98). These results show that AX gels could be carriers for lycopene delivery in colon due structure degradation by gut microbiota.
Scaffolds of Collagen from Nukbone ®
Authors: León Benjamín H. , Araiza Miguel A. , Piña M. Cristina 
Published: November 2012

ABSTRACTThe scaffold is obtained from acellular bovine bone: Nukbone® (produced by Biocriss SAPI de CV). This acellular bone was subjected to a demineralization process after which the composition was found to be 10% water, 65% of collagen and 25% of hydroxyapatite. The techniques used to characterize these natural scaffolds were: optical microscopy, scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, thermo gravimetric analysis, differential scanning calorimetry and determination of pore size using nitrogen adsorption, and physical adsorption of N2. The pore size is between 100 and 500 microns. These scaffolds have been tested in several biological tissues as urethra, trachea, blood vessels, bone and heart successfully.
Lubricin as a Surface Treatment to Reduce Post-operative Biofouling and Infection
Authors: Aninwene George E. , Hall Doug , Mei Amy , Jay Gregory D. , Webster Thomas J. 
Published: November 2012

ABSTRACTThe goal of this research was to investigate the ability of lubricin to prevent bio-fouling of intraocular lenses after surgery, through surface coating trials with lubricin and analogues of the two major sub-units of the lubricin molecule (mucin and vitronectin). Yearly, there are over 6 million surgeries worldwide that involve intraocular lenses (IOLs) 1. However, preventing post-operative biofouling and bacterial infection of these implants remains a challenge 2. Surface modification of IOLs may provide a solution. This study proposes the use of the anti-adhesive protein lubricin (LUB), a glycoprotein found in the synovial fluid, as a means to make polymer surfaces less prone to bacterial adhesion and proliferation; thus, reducing the opportunity for post-operative infection 3. This study used extended bacteria growth trials on tissue cultures polystyrene coated with either lubricin, vitronectin, or mucin to investigate how lubricin and protein sub-regions of lubricin may reduce bacterial adhesion and proliferation.