bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Bilateral Neck Metastasis of Tongue Cancer
Authors: Ishii Junichi , Yamashiro Masashi , Yamane Masashi , Ishikawa Hitoshi , Iwaki Hiroshi , Amagasa Teruo 
Published: August 2012

AbstractTo estimate the prognosis of bilateral cervical metastases from tongue carcinoma, we studied twelve patients (24‐72 years old) who underwent neck dissections at our hospital to judge whether we should have performed radical treatment or not for those patients of tongue carcinoma who had bilateral metastatic nodes.The five‐year survival rate of bilateral neck metastasis patients was 58% (the Kaplan‐Meier method). On the other hand, the five‐year survival rate of patients with only unilateral neck metastases of squamous cell carcinoma of the tongue was 56%. Thus, there was no statistical significant difference in survival rate.We conclude that even if a patient has metastatic lymph nodes on both sides of the neck, radical therapy should be done.
Cancer in Bone
Authors: Yoneda Toshiyuki 
Published: August 2012

AbstractBone is one of the most preferential metastatic target sites for cancers such as breast, prostate and lung cancers. Although the precise molecular mechanism underlying this preference needs to be elucidated, bone appears to possess unique biological microenvironments that allow circulating cancer cells to home, proliferate and survive. As a consequence of cancer expansion, cellular and molecular homeostasis of bone micro‐environments is disturbed and bone is destroyed, leading to the development of bone metastases. Thus, understanding of the crosstalk between cancer cells and bone is critical to design mechanism‐based effective and specific therapeutic interventions for bone metastases.
Radiological Morphometric Analysis for the Trabecular Bone Structure of Mandibular Condyle after Ovariectomy in Mature Cynomolgus Monkeys
Authors: Shimamoto Michiharu , Kozai Yusuke , Matsumoto Yukiko , Kawamata Ryota , Sakurai Takashi , Kashima Isamu 
Published: August 2012

AbstractTo investigate the effects of experimental osteoporosis on the trabecular structure of the mandibular condyle in cynomolgus monkeys by radiological bone morphometry, ovariectomy (OVX) was performed on 10‐year‐old female cynomolgus monkeys, which were fed a controlled diet for 2 years. Ten sham control groups were fed under the same conditions. Using a microfocus tube and computed radiography, the removed mandibular condyle samples were imaged by standardized magnification radiography. The structural parameters were measured using radiological bone morphometric analysis. The bone mineral density (BMD) was measured by dual energy X‐ray absorptiometry. The thickness of the cortical bone was measured using magnified radiographic images. The thickness of the cortical bone and the BMD in the OVX group were significantly lower than in the sham group. In the results of skeletal structure of the mandibular condyle, the trabecular structure of the mandibular condyle was markedly deteriorated in the OVX group. The trabecular structure of the mandibular condyle for the OVX group was significantly decreased, thus it was suggested that osteoporosis is a potential risk factor of osteoarthritis of the temporomandibular joint.
A Computational Tongue Model and its Clinical Application
Authors: Fujita Satoru , Dang Jianwu , Suzuki Noriko , Honda Kiyoshi 
Published: August 2012

AbstractThe tongue possesses a complex muscular structure, and its motor functions are also intricate. Therefore, it would be beneficial to use a computational physiological model of the tongue to examine its vital functions in normal and pathological conditions. Thus far, the studies of tongue models have focused on symmetric movements for normal speech. For clinical purposes, it is necessary to develop a physiological model to deal with daily vital activities such as mastication and swallowing. To do so, we constructed a full 3D physiological model of the tongue based on MRI data from a normal subject, and verified the basic functions of the model based on anatomic and physiological knowledge. In this study, the model was applied to clinical issues: prediction and verification of the changes in movements of the tongue with a tumor before and after partial glossectomy, respectively. Tongue protrusion and lateral bending motion were examined for the prediction and verification. The simulation results were consistent with the observations for a patient with a tumor in the tongue. Comparisons of the simulation and observation in the clinical case showed that the model could predict potential effects of the glossectomy on the tongue movements. It is suggested that the model is a useful tool for pre‐operative planning of glossectomy.
Secondary Squamous Cell Carcinoma of the Oral Cavity in Young Adults after Hematopoietic Stem Cell Transplantation for Leukemia: Report of Two Cases with Human Papillomavirus Infection
Authors: Kawano Kenji , Goto Hideyuki , Takahashi Yoshihiro , Kaku Yoshihisa , Oobu Kazunari , Yanagisawa Shigetaka 
Published: August 2012

AbstractTwo cases of secondary oral squamous cell carcinoma (SCC), which developed in recipients of hematopoietic stem cell transplantation (HSCT) for leukemia, are reported. The first patient underwent allogeneic HSCT for chronic myelogenous leukemia at 32 years of age. He suffered from chronic graft‐versus‐host‐disease (GVHD) of the oral mucosa after HSCT, and has subsequently received immunosuppressive therapy. He experienced metachronous multiple SCCs in the maxillary gingiva and the dorsum of the tongue at 36 years and 40 years of age, respectively. The second patient received autologous HSCT for acute myelogenous leukemia at 22 years of age, and she did not experience GVHD after transplantation. SCC developed in the lateral border of the tongue at 27 years of age. PCR analysis detected both HPV16 and HPV18 in the tongue tumor of the first patient, and only HPV18 in that of the second patient, suggesting that the infection of high‐risk HPVs was possibly involved in the development of post‐HSCT oral cancers in these patients. Since risk factors for post‐HSCT oral SCC are not yet well recognized, long‐term close follow‐up is necessary for the early detection of secondary oral cancers in all transplant recipients.
Possible Involvement of p38 MAP Kinase in Retinoid‐stimulated Expression of Indian Hedgehog in Prehypertrophic Chondrocytes
Authors: Shimo Tsuyoshi , Koyama Eiki , Ibaragi Soichiro , Kurio Naito , Yamamoto Daisuke , Okui Tatsuo , Kishimoto Koji , Mese Hiroshi , Sasaki Akira 
Published: August 2012

AbstractThe mandibular condyle formation during temporomandibular joint (TMJ) development exhibits endochondral bone formation, and the elongation process is dependent on the normal cartilage proliferation and differentiation. Retinoids are important for maturation of growth‐plate chondrocytes, but the identity of their downstream effectors remains unclear. In this study, we carried out a series of studies at the cellular, biochemical, and molecular levels to determine whether, and if so how, retinoid signaling is related to the expression and function of Indian hedgehog (Ihh) in chondrocyte proliferation. First we analyzed the RA receptor (RAR) and Ihh expression pattern in E18 mandibular condyle. RARα and RARβ mRNA were characterized in the perichondrium around the condyle, whereas RARγ mRNA was expressed in the immature and prehypertrophic chondrocytes and the expression was overlapped with Ihh gene expression. Next we established a high‐density culture model of chick cephalic chondrocytes in the prehypertrophic stage. We found that all‐trans retinoic acid (RA) induced Ihh mRNA gene expression in this system. The RA pan‐antagonist Ro 41‐5253 inhibited both endogenous and RA‐induced Ihh mRNA in a dose‐dependent manner. The Ihh mRNA expression induced by RA required de novo protein synthesis, and was mediated by RARγ. Immunoblots showed that the prehypertrophic chondrocytes contained sizable levels of phosphorylated p38 mitogen‐activated protein (MAP) kinase that were time‐ and dose‐dependently increased by the RA treatment. Experimental p38 inhibition led to a severe drop in baseline and RA‐stimulated Ihh expression. Exogenous recombinant Ihh stimulated the proliferation of proliferating chondrocytes, whereas RA inhibited the proliferation of these chondrocytes through p38 MAPK. Retinoids appear to play a primary role in controlling both the expression and function of Ihh in prehypertrophic chondrocytes and do so via p38 MAP kinase.
Detection and Analysis of Helicobacter pylori DNA in the Gastric Juice, Saliva, and Urine by Nested PCR
Authors: Yamada Ryuhei , Yamaguchi Akira , Shibasaki Koichi 
Published: August 2012

AbstractThe aim of this study was to investigate the strain heterogeneity of Helicobacter pylori (H. pylori) in saliva, gastric juice, and urine by nested PCR and the direct sequence method, and to clarify the mode of transmission by examining whether H. pylori in the stomach and saliva are identical.Thirty‐nine patients undergoing endoscopy were enrolled in this study. H. pylori DNA was assayed in 104 samples using two sets of primers, EHC‐U/EHC‐L and ET‐5U/ET‐5L. DNA sequencing was performed in 24 samples.H. pylori DNA was detected in 39 gastric juice samples (100%) and in 28 saliva samples (71.8%). The prevalence in urine samples was 50% (13/26). All samples except one were identical with over 97% identity to the DNA sequence of H. pylori type strain J99 (USA).Nested PCR was highly sensitive for detection of H. pylori DNA in saliva, and DNA sequencing may be useful to clarify the mode of transmission.
Increased Expression of CENP‐H Gene in Human Salivary Gland Carcinomas
Authors: Shigeishi Hideo , Mitani Yoshitsugu , Ono Shigehiro , Ohta Kouji , Higashikawa Koichiro , Taki Masayuki , Kamata Nobuyuki 
Published: August 2012

AbstractThere have been very few studies on the expression of Centromere proteins in human salivary gland carcinomas. The purpose of this study was to clarify the correlation between Centromere protein H (CENP‐H) expression and clinicopathologic factors in salivary gland carcinomas. The expression of CENP‐H mRNA was investigated in 28 human salivary gland tumors (7 pleomorphic adenomas, 3 Warthin tumors, 6 mucoepidermoid carcinomas, 6 adenoid cystic carcinomas, 5 acinic cell carcinomas and 1 malignant myoepithelioma) and 8 normal submandibular glands using real‐time quantitative reverse transcription‐polymerase chain reaction (RT‐PCR). The labeling index of PCNA and Ki‐67 were also investigated immunohistochemically in 16 salivary gland carcinomas. The mean expression level of CENP‐H mRNA was significantly higher in malignant tumors (0.55 ± 0.68) than normal submandibular glands (0.10 ± 0.029). A significant correlation between the PCNA labeling index and CENP‐H mRNA expression was also found (Spearman’s correlation coefficient by rank test, P=0.033). We also found a significant correlation between the Ki‐67 labeling index and CENP‐H mRNA expression in malignant tumors (Spearman’s correlation coefficient by rank test, P=0.040). These results indicate that human CENP‐H mRNA is closely linked to increased or abnormal cell proliferation in malignant salivary gland tumors.
Inhibition of Rac Induces Hyper‐Activation of c‐Jun N‐Terminal Kinase and Caspase‐Dependent Apoptosis
Authors: Matsuoka Yudai , Nakahara Hirokazu , Nozaki Shinichi , Otani Tomohiro , Kogo Mikihiko 
Published: August 2012

AbstractApoptosis is one mechanism by which cancer cells can be eliminated. Therefore, understanding the signaling pathways that transduce apoptotic signals in cancer cells is an indispensable component of cancer research. Rac, a member of the Rho family of proteins, has been implicated in the regulation of cell survival and apoptosis. However, the mechanisms underlying this process remain to be elucidated. To understand the role of Rac in oral squamous cancer, we inhibited its activity by a Rac‐specific small molecule inhibitor, NSC23766, or transfection of dominant negative Rac (Rac‐DN), and discovered that inhibition of Rac activity elicits apoptosis in highly malignant oral squamous carcinoma (OSC‐19) cells. Upon suppression of Rac, we observed up‐regulation of c‐Jun N‐terminal kinase (JNK), leading to caspase‐dependent apoptosis. Furthermore, stimulation of protein phosphatase (PP5) rescued apoptosis caused by Rac inhibition by dephosphorylating JNK. Taken together, inhibition of Rac activity leads to the suppression of PP5 activity, which results in extensive activation of JNK and caspase‐dependent apoptosis. In conclusion, Rac inhibition may represent a novel therapeutic approach for oral squamous carcinoma.
Intramuscular Lipoma of the Cheek: Report of Two Cases
Authors: Hashitani Susumu , Toyohara Yukiyo , Sakurai Kazunari , Urade Masahiro 
Published: August 2012

AbstractTwo cases of intramuscular lipoma occurring in the cheek of a 39‐year‐old and of a 55‐year‐old Japanese males are presented. These were excised by the intraoral approach. Histopathologically, these lesions were composed of the adipose cell‐like tumor cells infiltrating in the striated muscles. There has been no evidence of tumor recurrence after operation.
Computed Tomographic Evaluation of Bone Quality of the Mandible Reconstructed by Particular Cellular Bone and Marrow Combined with Platelet Rich Plasma
Authors: Iwamoto Muneharu , Matsuo Akira , Kato Noriko , Takeuchi Sawako , Takahashi Hidetoshi , Hojo Satoru , Chiba Hiroshige 
Published: August 2012

AbstractConcerning the bone structures of the mandible reconstructed by particular cellular bone and marrow (PCBM), platelet rich plasma (PRP) and tray, we have examined the possibility of implant insertion by clarifying the morphological conditions in each compact and cancellous bone on computed tomography (CT), and by observing the differences in their CT values.Using the computer software program Sim Plant (Materialize Dental, Leuven, Belgium), we morphologically observed 6 cases of implant inserted area after mandibular reconstruction and 11 cases of native bone, and examined the differences in their CT values. The osseointegration rate of each inserted implant was also evaluated.Compared with the native bone group, the PCBM reconstruction group had generally thin compact bone. In the over‐3 cm‐length PCBM reconstruction group, the average CT value was 259.7 ± 94.4 HU (n = 3) in the cancellous bone, whereas in the native bone group, the average CT value was 528.9 ± 140.1 HU (n = 10). Therefore, the PCBM reconstruction group showed significantly lower CT value than the native bone group. However, in the under‐3 cm‐length group, the PCBM reconstruction group showed no significant difference compared with the native bone group. The osseointegration rate of the inserted implants almost 6 months after insertion was 100% in the PCBM reconstruction group and 94.1% in the native bone group.Although the PCBM reconstructed bone had thinner cortical bone and showed lower CT value compared with the native bone, implant insertion was possible.
Side‐to‐side Asymmetry in Trigeminal Neuralgia
Authors: Toda Katsuhiro 
Published: August 2012

AbstractThe right side was affected in 61% of reported cases and the left side was affected in 39% of approximately 30,000 patients with trigeminal neuralgia (TN) affected on only one side. side‐to‐side asymmetry of neurovascular compression in healthy persons cannot account for side‐to‐side asymmetry in TN. Size asymmetry and shape asymmetry of the rotundum and ovale foramens may account for the higher incidence of TN on the right side. This paper proposes a multiple factors theory: the summation of multiple factors reaches a critical level at which TN occurs. It is rational that entrapment of the maxillary and mandibular nerves when they cross the ovale and rotundum foramens is one of the factors which cause TN. The multiple factors theory can account for a TN patient without neurovascular compression and a healthy person with neurovascular compression.
Fibroma of the Tendon Sheath Arising from the Synovial Membrane of the Temporomandibular Joint
Authors: Toyoda Nagataka , Sato Toru , Asada Koichi , Satomura Kazuhito 
Published: August 2012

AbstractFibroma of the tendon sheath (FTS) involving the temporomandibular joint (TMJ) is very rare. A case of FTS arising from the synovial membrane of the TMJ is presented. The patient was a 17‐year‐old male with jaw opening pain and clicking in the left TMJ. MRI, arthrotomography, and arthroscopy showed a well‐circumscribed mass that was localized in the superior articular cavity of the left TMJ. The tumor was removed with the attached synovial membrane. Macroscopic, histological and immunohistological features of the intra‐articular tumor were identical to FTS. There have been no signs of recurrence in the 6 years since surgery.
A Case of Impacted Supernumerary Fourth Molar in the Bilateral Mandibular Ramus
Authors: Sumida Tomoki , Murase Ryuichi , Yoshimura Tomohide , Aramoto Takayoshi , Ishikawa Akiko , Hamakawa Hiroyuki 
Published: August 2012

AbstractThe occurrence of multiple supernumerary teeth in individuals without any associated syndrome is rare. In this report, a rare case of a 48‐year‐old woman who had an impacted supernumerary fourth molar in the bilateral mandibular ramus is described. She presented with a swelling in the left cheek region. Radiographic examination revealed an impacted supernumerary tooth in the left mandibular ramus with pericoronal resorption of the bone, suggesting peripheral inflammation. She also had an impacted supernumerary tooth on the right side. After administering an antibiotic and antiinflammatory drug, tooth extraction was performed under general anesthesia.
Inflammation and Atrial Fibrillation
Authors: Endoh Yasumi , Endoh Ikuko , Geczy Carolyn , Nakagomi Akihiro , Kusama Yoshiki , Atarashi Hirotsugu 
Published: August 2012

AbstractAtrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice. Accumulating evidence indicates a link between inflammation and AF, and important advances in understanding mechanisms of AF are arising from studies of the critical components involved in the modulation of the immunoinflammatory balance within the atrium. However, molecular mechanisms remain unclear. Indeed, although preclinical and clinical studies suggest that chronic inflammation may promote development of AF, the roles of inflammation in the process are complex and incompletely understood. The purpose of this review is to briefly highlight current evidence on relationships between inflammation and AF, and to discuss possible mechanisms of development of AF and/or possible therapeutic approaches targeting components of the inflammatory response.
What Can We Expect from the ISSUE 3 Trial?
Authors: Sutton Richard , Brignole Michele 
Published: August 2012

AbstractThe ISSUE 3 Trial is designed to demonstrate which patients with vasovagal syncope over the age of 40 years will benefit from pacing dual chamber with the rate drop response. The trial has completed its recruitment of 521 patients and 78 have now been randomized in Phase 2, which is the Pacing ON versus Pacing OFF comparison. During this Phase the end‐points are recurrence of syncope or two years of follow‐up without recurrence. It has been calculated that 27 early end‐points will be sufficient to determine a significant difference between the groups. The background, details and design of the trial are explained. Some early findings are presented. Definitive results are expected by the end of 2011.
Non-recurrence sets for weakly mixing linear dynamical systems
Authors: GRIVAUX SOPHIE 
Published: August 2012

AbstractWe study non-recurrence sets for weakly mixing dynamical systems by using linear dynamical systems. These are systems consisting of a bounded linear operator acting on a separable complex Banach space$X$, which becomes a probability space when endowed with a non-degenerate Gaussian measure. We generalize some recent results of Bergelson, del Junco, Lemańczyk and Rosenblatt, and show in particular that sets$\{n_{k}\}$such that$n_{k+1}/n_{k}\to +\infty $, or such that$n_{k}$divides$n_{k+1}$for each$k\ge 0$, are non-recurrence sets for weakly mixing linear dynamical systems. We also give examples, for each$r\ge 1$, of$r$-Bohr sets which are non-recurrence sets for some weakly mixing systems.
Experimental study of particle-driven secondary flow in turbulent pipe flows
Authors: Belt R. J. , Daalmans A. C. L. M. , Portela L. M. 
Published: August 2012

AbstractIn fully developed single-phase turbulent flow in straight pipes, it is known that mean motions can occur in the plane of the pipe cross-section, when the cross-section is non-circular, or when the wall roughness is non-uniform around the circumference of a circular pipe. This phenomenon is known as secondary flow of the second kind and is associated with the anisotropy in the Reynolds stress tensor in the pipe cross-section. In this work, we show, using careful laser Doppler anemometry experiments, that secondary flow of the second kind can also be promoted by a non-uniform non-axisymmetric particle-forcing, in a fully developed turbulent flow in a smooth circular pipe. In order to isolate the particle-forcing from other phenomena, and to prevent the occurrence of mean particle-forcing in the pipe cross-section, which could promote a different type of secondary flow (secondary flow of the first kind), we consider a simplified well-defined situation: a non-uniform distribution of particles, kept at fixed positions in the ‘bottom’ part of the pipe, mimicking, in a way, the particle or droplet distribution in horizontal pipe flows. Our results show that the particles modify the turbulence through ‘direct’ effects (associated with the wake of the particles) and ‘indirect’ effects (associated with the global balance of momentum and the turbulence dynamics). The resulting anisotropy in the Reynolds stress tensor is shown to promote four secondary flow cells in the pipe cross-section. We show that the secondary flow is determined by the projection of the Reynolds stress tensor onto the pipe cross-section. In particular, we show that the direction of the secondary flow is dictated by the gradients of the normal Reynolds stresses in the pipe cross-section, $\partial {\tau }_{rr} / \partial r$ and $\partial {\tau }_{\theta \theta } / \partial \theta $. Finally, a scaling law is proposed, showing that the particle-driven secondary flow scales with the root of the mean particle-forcing in the axial direction, allowing us to estimate the magnitude of the secondary flow.
On flow in weakly precessing cylinders: the general asymptotic solution
Authors: Liao Xinhao , Zhang Keke 
Published: August 2012

AbstractWe investigate, through both asymptotic and numerical analysis, precessionally driven flow of a homogeneous fluid confined in a fluid-filled circular cylinder that rotates rapidly about its symmetry axis and precesses slowly about a different axis that is fixed in space. After demonstrating that the inviscid approximation is always divergent even far away from resonance, we derive a general asymptotic solution for an asymptotically small Ekman number in the rotating frame of reference describing the weakly precessing flow that satisfies the no-slip boundary condition and that is valid at or near or away from resonance. Numerical analysis of the same problem using the Galerkin method in terms of a Chebyshev polynomial expansion is also carried out, showing satisfactory agreement between the general asymptotic solution and the corresponding numerical solution at or near or away from resonance.